bluuebunny/crossref_metadata_2025_split huggingface dataset:
A large scale study of reader interactions with images on Wikipedia
Authors: Rama Daniele , Piccardi Tiziano , Redi Miriam , Schifanella Rossano 
Published: January 2022

AbstractWikipedia is the largest source of free encyclopedic knowledge and one of the most visited sites on the Web. To increase reader understanding of the article, Wikipedia editors add images within the text of the article’s body. However, despite their widespread usage on web platforms and the huge volume of visual content on Wikipedia, little is known about the importance of images in the context of free knowledge environments. To bridge this gap, we collect data about English Wikipedia reader interactions with images during one month and perform the first large-scale analysis of how interactions with images happen on Wikipedia. First, we quantify the overall engagement with images, finding that one in 29 pageviews results in a click on at least one image, one order of magnitude higher than interactions with other types of article content. Second, we study what factors associate with image engagement and observe that clicks on images occur more often in shorter articles and articles about visual arts or transports and biographies of less well-known people. Third, we look at interactions with Wikipedia article previews and find that images help support reader information need when navigating through the site, especially for more popular pages. The findings in this study deepen our understanding of the role of images for free knowledge and provide a guide for Wikipedia editors and web user communities to enrich the world’s largest source of encyclopedic knowledge.
Challenges for FCC-ee luminosity monitor design
Authors: Dam Mogens 
Published: January 2022

AbstractFor cross section measurements, an accurate knowledge of the integrated luminosity is required. The FCC-ee physics programme at and around the Z pole sets the ambitious precision goal of $$10^{-4}$$

10

-
4

on the absolute luminosity measurement and one order of magnitude better on the relative measurement between energy scan points. The luminosity is determined from the rate of Bhabha scattering, $$\mathrm {e^+e^- \rightarrow e^+e^-}$$

e
+

e
-

→

e
+

e
-

, where the final state electrons and positrons are detected in dedicated monitors covering small angles from the outgoing beam directions. The constraints on the luminosity monitors are multiple: (i) they are placed inside the main detector volume only about 1 m from the interaction point; (ii) they are centred around the outgoing beam directions and do not satisfy the normal axial detector symmetry; (iii) their coverage is limited by the beam pipe, on the one hand, and by the requirement to stay clear of the main detector acceptance, on the other; (iv) the steep angular dependence of the Bhabha scattering process imposes a precision on the acceptance limits at about 1 $$\upmu $$
μ
rad, corresponding to an absolute geometrical precision of $${\mathcal {O}}(1\,\upmu \text {m})$$

O
(
1

μ
m
)

on the monitor radial dimensions; and v) the very high bunch-crossing rate of 50 MHz during the Z-pole operation calls for fast readout electronics. Inspired by second-generation LEP luminosity monitors, which achieved an experimental precision of $$3.4 \times 10^{-4}$$

3.4
×

10

-
4

on the absolute luminosity measurement (Abbiendi et al. in Eur Phys J C 14:373–425, 2000), a proposed ultra-compact solution is based on a sandwich of tungsten-silicon layers. A vigorous R &D programme is needed in order to ensure that such a solution satisfies the more challenging FCC-ee requirements.
Non-invasive identification of textile fibres using near-infrared fibre optics reflectance spectroscopy and multivariate classification techniques
Authors: Quintero Balbas Diego , Lanterna Giancarlo , Cirrincione Claudia , Fontana Raffaella , Striova Jana 
Published: January 2022

AbstractThe identification of textile fibres from cultural property provides information about the object's technology. Today, microscopic examination remains the preferred method, and molecular spectroscopies (e.g. Fourier transform infrared (FTIR) and Raman spectroscopies) can complement it but may present some limitations. To avoid sampling, non-invasive fibre optics reflectance spectroscopy (FORS) in the near-infrared (NIR) range showed promising results for identifying textile fibres; but examining and interpreting numerous spectra with features that are not well defined is highly time-consuming. Multivariate classification techniques may overcome this problem and have already shown promising results for classifying textile fibres for the textile industry but have been seldom used in the heritage science field. In this work, we compare the performance of two classification techniques, principal component analysis–linear discrimination analysis (PCA-LDA) and soft independent modelling of class analogy (SIMCA), to identify cotton, wool, and silk fibres, and their mixtures in historical textiles using FORS in the NIR range (1000–1700 nm). We built our models analysing reference samples of single fibres and their mixtures, and after the model calculation and evaluation, we studied four historical textiles: three Persian carpets from the nineteenth and twentieth centuries and an Italian seventeenth-century tapestry. We cross-checked the results with Raman spectroscopy. The results highlight the advantages and disadvantages of both techniques for the non-invasive identification of the three fibre types in historical textiles and the influence their vicinity can have in the classification.
Sapanisertib plus Fulvestrant in Postmenopausal Women with Estrogen Receptor–Positive/HER2-Negative Advanced Breast Cancer after Progression on Aromatase Inhibitor
Authors: García-Sáenz José Á. , Martínez-Jáñez Noelia , Cubedo Ricardo , Jerez Yolanda , Lahuerta Ainhara , González-Santiago Santiago , Ferrer Nieves , Ramos Manuel , Alonso-Romero Jose L. , Antón Antonio , Carrasco Eva , Chen Jingjing , Neuwirth Rachel , Galinsky Kevin , Vincent Sylvie , Leonard E. Jane , Slamon Dennis 
Published: January 2022

Abstract

Purpose:
This phase II study investigated daily or weekly sapanisertib (a selective dual inhibitor of mTOR complexes 1 and 2) in combination with fulvestrant.

Patients and Methods:
Postmenopausal women with estrogen receptor–positive (ER+)/HER2-negative (HER2−) advanced or metastatic breast cancer following progression during/after aromatase inhibitor treatment were randomized to receive fulvestrant 500 mg (28-day treatment cycles), fulvestrant plus sapanisertib 4 mg daily, or fulvestrant plus sapanisertib 30 mg weekly, until progressive disease, unacceptable toxicity, consent withdrawal, or study completion.

Results:
Among 141 enrolled patients, baseline characteristics were balanced among treatment arms, including prior cyclin-dependent kinase-4/6 (CDK4/6) inhibitor treatment in 33% to 35% of patients. Median progression-free survival (PFS; primary endpoint) was 3.5 months in the single-agent fulvestrant arm, compared with 7.2 months for fulvestrant plus sapanisertib daily [HR, 0.77; 95% confidence interval (CI), 0.47–1.26] and 5.6 months for fulvestrant plus sapanisertib weekly (HR, 0.88; 95% CI, 0.53–1.45). The greatest PFS benefits were seen in patients who had previously received CDK4/6 inhibitors. The most common adverse events were nausea, vomiting, and hyperglycemia, all occurring more frequently in the combination therapy arms. Treatment discontinuation due to adverse events occurred more frequently in the two combination therapy arms than with single-agent fulvestrant (32% and 36% vs. 4%, respectively).

Conclusions:
Fulvestrant plus sapanisertib daily/weekly resulted in numerically longer PFS in patients with ER+/HER2− advanced or metastatic breast cancer, compared with single-agent fulvestrant. The combination was associated with increased toxicity. Further development of sapanisertib using these dosing schedules in this setting is not supported by these data.
Genetic Subtyping and Phenotypic Characterization of the Immune Microenvironment and MYC/BCL2 Double Expression Reveal Heterogeneity in Diffuse Large B-cell Lymphoma
Authors: Xu-Monette Zijun Y. , Wei Li , Fang Xiaosheng , Au Qingyan , Nunns Harry , Nagy Máté , Tzankov Alexandar , Zhu Feng , Visco Carlo , Bhagat Govind , Dybkaer Karen , Chiu April , Tam Wayne , Zu Youli , Hsi Eric D. , Hagemeister Fredrick B. , Sun Xiaoping , Han Xin , Go Heounjeong , Ponzoni Maurilio , Ferreri Andrés J.M. , Møller Michael B. , Parsons Benjamin M. , van Krieken J. Han , Piris Miguel A. , Winter Jane N. , Li Yong , Xu Bing , Albitar Maher , You Hua , Young Ken H. 
Published: January 2022

Abstract

Purpose:
Diffuse large B-cell lymphoma (DLBCL) is molecularly and clinically heterogeneous, and can be subtyped according to genetic alterations, cell-of-origin, or microenvironmental signatures using high-throughput genomic data at the DNA or RNA level. Although high-throughput proteomic profiling has not been available for DLBCL subtyping, MYC/BCL2 protein double expression (DE) is an established prognostic biomarker in DLBCL. The purpose of this study is to reveal the relative prognostic roles of DLBCL genetic, phenotypic, and microenvironmental biomarkers.

Experimental Design:
We performed targeted next-generation sequencing; IHC for MYC, BCL2, and FN1; and fluorescent multiplex IHC for microenvironmental markers in a large cohort of DLBCL. We performed correlative and prognostic analyses within and across DLBCL genetic subtypes and MYC/BCL2 double expressors.

Results:
We found that MYC/BCL2 double-high-expression (DhE) had significant adverse prognostic impact within the EZB genetic subtype and LymphGen-unclassified DLBCL cases but not within MCD and ST2 genetic subtypes. Conversely, KMT2D mutations significantly stratified DhE but not non-DhE DLBCL. T-cell infiltration showed favorable prognostic effects within BN2, MCD, and DhE but unfavorable effects within ST2 and LymphGen-unclassified cases. FN1 and PD-1–high expression had significant adverse prognostic effects within multiple DLBCL genetic/phenotypic subgroups. The prognostic effects of DhE and immune biomarkers within DLBCL genetic subtypes were independent although DhE and high Ki-67 were significantly associated with lower T-cell infiltration in LymphGen-unclassified cases.

Conclusions:
Together, these results demonstrated independent and additive prognostic effects of phenotypic MYC/BCL2 and microenvironment biomarkers and genetic subtyping in DLBCL prognostication, important for improving DLBCL classification and identifying prognostic determinants and therapeutic targets.
Exposure–Response Analysis to Support Nivolumab Once Every 4 Weeks Dosing in Combination with Cabozantinib in Renal Cell Carcinoma
Authors: Hamuro Lora , Hu Zheyi , Passarell Julie , Barcomb Heather , Zhang Joshua , Goldstein Shay , Bello Akintunde , Roy Amit , Zhu Li 
Published: January 2022

Abstract

Purpose:
A benefit:risk assessment for a less-frequent nivolumab 480 mg every 4 weeks + cabozantinib 40 mg every day dosing regimen was predicted using modeling and simulation of clinical trial data from nivolumab monotherapy studies and from the nivolumab 240 mg every 2 weeks + cabozantinib 40 mg every day dosing regimen, which demonstrated clinical benefit versus sunitinib in previously untreated advanced renal cell carcinoma (aRCC) in the phase III CheckMate 9ER trial (NCT03141177).

Patients and Methods:
Multivariable Cox proportional hazards analyses were conducted using nivolumab monotherapy data in previously treated aRCC and data from CheckMate 9ER to evaluate progression-free survival (PFS), overall survival (OS), and grade ≥2 immune-mediated adverse events (IMAE).

Results:
Nivolumab 240 mg every 2 weeks + cabozantinib versus nivolumab monotherapy showed improvement in PFS (HR, 0.38; 95% CI, 0.31–0.47), OS (HR, 0.63; 95% CI, 0.46–0.85), and increased risk of grade ≥2 IMAEs (HR, 2.19; 95% CI, 1.79–2.67). Nivolumab exposure was not a predictor of PFS/OS or grade ≥2 IMAEs. Lower nivolumab clearance, male sex, higher baseline bodyweight, and Karnofsky performance (100) were each associated with PFS/OS improvements. Region and International Metastatic Renal Cell Carcinoma Database Consortium poor score were negative OS predictors. Age, baseline albumin, and programmed death ligand 1 status were not significant PFS/OS predictors. Cabozantinib was a significant grade ≥2 IMAE predictor, driven by diarrhea and hepatic events. Model-predicted PFS/OS and grade ≥2 IMAE rates were similar (&lt;2.5% difference) for nivolumab 240 mg every 2 weeks + cabozantinib and 480 mg every 4 weeks + cabozantinib.

Conclusions:
Comparable benefit:risk was predicted for nivolumab 480 mg every 4 weeks + cabozantinib and nivolumab 240 mg every 2 weeks + cabozantinib.
Association Between Aspirin Use and Gastric Adenocarcinoma: A Prospective Cohort Study
Authors: Kwon Sohee , Ma Wenjie , Drew David A. , Klempner Samuel J. , Leonardo Brianna M. , Flynn Jacqueline J. , Cao Yin , Giovannucci Edward L. , Bao Ying , Fuchs Charles S. , Song Mingyang , Chan Andrew T. 
Published: January 2022

Abstract

Prospective data examining the association of aspirin use, according to dose and duration, with long-term risk of gastric adenocarcinoma in non-Asian cohorts are lacking. We evaluated the association between aspirin use and risk of gastric adenocarcinoma in two large prospective U.S. cohort studies, the Nurses' Health Study and the Health Professionals Follow-up Study. Cox proportional hazards regression models were used to calculate multivariable adjusted HRs and 95% confidence intervals (CI). Among the 159,116 participants, we documented 316 gastric adenocarcinoma cases (176 women, 140 men) over 34 years encompassing 4.5 million person-years. Among women, regular aspirin use (at least two times or more per week) was significantly associated with lower risk of gastric adenocarcinoma (multivariable HR, 0.52; 95% CI, 0.37–0.73) compared with nonregular use. However, regular aspirin use was not associated with gastric adenocarcinoma risk among men (multivariable HR, 1.08; 95% CI, 0.77–1.52; Pheterogeneity for sex = 0.003). Among women, the lower risk of gastric adenocarcinoma was more apparent with increasing duration of aspirin use (Ptrend &lt; 0.001) and more than five tablets per week (multivariable HR, 0.51; 95% CI, 0.31–0.84). Regular, long-term aspirin use was associated with lower risk of gastric adenocarcinoma among women, but not men. The benefit appeared after at least 10 years of use and was maximized at higher doses among women. The heterogeneity by sex in the association of aspirin use with risk of gastric adenocarcinoma requires further investigation.

Prevention Relevance:
Novel prevention is urgently needed to reduce incidence and mortality of gastric cancer. We found that regular aspirin use was associated with lower risk of gastric adenocarcinoma among women, but not men. The benefit appeared after at least 10 years of use and was maximized at higher doses among women.
See related Spotlight, p. 213
Quantifying Cognitive Factors in Lexical Decline
Authors: Francis David , Rabinovich Ella , Samir Farhan , Mortensen David , Stevenson Suzanne 
Published: January 2022

AbstractWe adopt an evolutionary view on language change in which cognitive factors (in addition to social ones) affect the fitness of words and their success in the linguistic ecosystem. Specifically, we propose a variety of psycholinguistic factors—semantic, distributional, and phonological—that we hypothesize are predictive of lexical decline, in which words greatly decrease in frequency over time. Using historical data across three languages (English, French, and German), we find that most of our proposed factors show a significant difference in the expected direction between each curated set of declining words and their matched stable words. Moreover, logistic regression analyses show that semantic and distributional factors are significant in predicting declining words. Further diachronic analysis reveals that declining words tend to decrease in the diversity of their lexical contexts over time, gradually narrowing their ‘ecological niches’.
Idiomatic Expression Identification using Semantic Compatibility
Authors: Zeng Ziheng , Bhat Suma 
Published: January 2022

AbstractIdiomatic expressions are an integral part of natural language and constantly being added to a language. Owing to their non-compositionality and their ability to take on a figurative or literal meaning depending on the sentential context, they have been a classical challenge for NLP systems. To address this challenge, we study the task of detecting whether a sentence has an idiomatic expression and localizing it when it occurs in a figurative sense. Prior research for this task has studied specific classes of idiomatic expressions offering limited views of their generalizability to new idioms. We propose a multi-stage neural architecture with attention flow as a solution. The network effectively fuses contextual and lexical information at different levels using word and sub-word representations. Empirical evaluations on three of the largest benchmark datasets with idiomatic expressions of varied syntactic patterns and degrees of non-compositionality show that our proposed model achieves new state-of-the-art results. A salient feature of the model is its ability to identify idioms unseen during training with gains from 1.4% to 30.8% over competitive baselines on the largest dataset.
Reconstruction of intrageneric relationships within the Indo-West Pacific littoral crab genus Metopograpsus (Decapoda, Brachyura, Grapsidae): an alternative speciation order according to a 28S rDNA molecular phylogeny
Authors: Mock Elisabeth , Schubart Christoph D. 
Published: January 2022

Abstract
The genus Metopograpsus H. Milne Edwards, 1853 is widespread throughout the Indo-West Pacific and currently consists of seven species that can only be separated by minor morphological differences. Therefore, it represents a good example for the usefulness of genetic analyses for identification and classification. In order to obtain phylogenetic information at both lower and higher evolutionary levels, it is best to use a combination of mitochondrial and nuclear molecular markers. Here we present for the first time a molecular phylogeny based on a relative long fragment of the 28S rRNA nuclear gene for the genus Metopograpsus, after application of newly developed primers. Our data suggest an alternative intrageneric speciation order, with M. thukuhar and M. cannicci holding a basal position and a monophyletic grouping of M. frontalis, M. oceanicus and M. quadridentatus, which differs from prior phylogenetic reconstructions. Previously recognized intraspecific phylogeographic patterns in M. latifrons and M. quadridentatus could not be confirmed, due to limited variability of this conserved nuclear gene and due to an incomplete geographic coverage of the corresponding species. In contrast, the previously indicated phylogenetic subdivision within the formerly widespread species M. thukuhar, which led to the recent description of M. cannicci, is here supported.
Microanatomy of the antennal glands and their Na+/K+-ATPase activity in three true crab species (Brachyura), Portunus pelagicus (Linnaeus, 1758) (Portunidae), Macrophthalmus dentipes Lucas in Guérin, 1836 (Macrophthalmidae) and Eriocheir hepuensis Dai, 1991 (Varunidae)
Authors: Khalifi Khadijeh , Salamat Negin , Movahedinia Abdolali 
Published: January 2022

Abstract
There are differences between various crab species in the function and structure of organs involved in ionic and osmotic regulation processes. The antennal glands together constitute one of the most important organs involved in the osmoregulation in crabs. The present investigation aimed to study the tissue structure of the antennal glands and their Na+/K+-ATPase (NKA) pump activity in three true crab species from three different habitats, including the marine (Portunus pelagicus (Linnaeus, 1758)), the estuarine (Macrophthalmus dentipes Lucas in Guérin, 1836) and the freshwater habitat (Eriocheir hepuensis Dai, 1991). In this regard, the tissue structure of the antennal glands and the activity of the Na+/K+-ATPase (NKA) pump were assessed in these three selected species. The results showed that the antennal glands in all studied species consisted of two anterior parts and a posterior part. The anterior parts are composed of the proximal tubular region (PT) and the distal tubular region (DT). The PT and DT parts comprised the coelomosac and labyrinths in the anterior portion, and the bladder located in the posterior portion. However, despite the similarity in the general tissue structure of the antennal gland in marine, estuarine and freshwater crab species, some structural differences were observed between those species. Labyrinth cells, coelomosac podocytes, and bladder cells in the estuarine crab M. dentipes contained large vacuoles especially on the top (i.e., near the lumen) of the cells. The highest amount of NKA pump activity was measured in the antennal glands of M. dentipes (). The NKA pump plays a more important role in the estuary and seawater adaptation of crabs, but freshwater species are not highly dependent on the NKA enzyme for osmoregulation.
A new species of Eusirus (Amphipoda, Amphilochidea, Eusiridae) described from a hydrothermal vent in the Okinawa Trough, North-West Pacific
Authors: Wang Yanrong , Sha Zhongli , Ren Xianqiu 
Published: January 2022

Abstract
A new species of Eusiridae, Eusirus liui sp. nov. is described from a hydrothermal vent on Okinawa Trough, North-West Pacific. The new species differs from the other 30 congeneric species mainly by the following combination of characters: the acute rostrum reaching to 1/3 the length of peduncular article 1 of antenna 1; the absence of eyes; pleonite 3 without acute protrusion on dorsal margin, and the posterior margin of epimeron 3 with 18 serrations. A key to all known Eusirus species is provided herein. This is the fourth species within the Eusiridae that has been found from vent fields.
Allometry of the box crab Calappa convexa De Saussure, 1853 (Brachyura, Calappidae) in the southeastern Gulf of California
Authors: Arvizu-Merín Carlos A. , Arzola-González Juan F. , Félix-Ortiz José A. , Rodríguez-Domínguez Guillermo , Marín-Enríquez Emigdio , Aragón-Noriega E. Alberto 
Published: January 2022

Abstract
The relative growth of Calappa convexa can be used to identify dimorphism or morphological change related to sexual maturation. The carapace width (CW) against width and length of the propodus of the right and left cheliped were tested to obtain a coefficient of allometry. CW against total wet weight WT values were analysed for length-weight relationships (LWR). Relative growth was analysed by a multi-model approach. Five models were tested and the best was selected due to the greater weight of the Akaike criterion (). Significant differences between sexes were found in CW (, ) and WT (, ). The negative or positive allometry varied according to the morphometric relationship and sex. No real winner model () was observed in the LWR analysis under a multi-model approach. The average model estimated a breakpoint at 118 mm CW in males and 132 mm CW in females.
Presence of Conchoderma auritum and C. virgatum (Maxillopoda, Lepadidae) and Gloiopotes huttoni (Copepoda, Caligidae) on the black marlin, from the Gulf of Tehuantepec, Mexico
Authors: Anislado-Tolentino Vicente , Del Moral-Flores Luis F. , Wakida-Kusunoki Armando T. , del S. Andrade-González Zullette 
Published: January 2022

Abstract
This is the first report of coexistence of pedunculate barnacles, Conchoderma auritum and C. virgatum in the mouth, and with the copepod Gloiopotes huttoni in the precaudal zone, on the black marlin, Istiompax indica, a as host. This is also the first note of a new non-mammalian host for C. auritum. The host specimen was caught in sport fishing in the Gulf of Tehuantepec, eastern Pacific. A review of registered occurrences of the genus Conchoderma in species of the fish family Istiophoridae is provided.