bluuebunny/crossref_metadata_2025_split huggingface dataset:
Direct-Acting Antivirals as Primary Treatment for Hepatitis C Virus–Associated Indolent Non-Hodgkin Lymphomas: The BArT Study of the Fondazione Italiana Linfomi
Authors: Merli Michele , Rattotti Sara , Spina Michele , Re Francesca , Motta Marina , Piazza Francesco , Orsucci Lorella , Ferreri Andrés J.M. , Perbellini Omar , Dodero Anna , Vallisa Daniele , Pulsoni Alessandro , Santoro Armando , Sacchi Paolo , Zuccaro Valentina , Chimienti Emanuela , Russo Filomena , Visco Carlo , Zignego Anna Linda , Marcheselli Luigi , Passamonti Francesco , Luminari Stefano , Paulli Marco , Bruno Raffaele , Arcaini Luca ,   on behalf of Fondazione Italiana Linfomi
Published: June 2022

PURPOSE We prospectively treated patients with hepatitis C virus (HCV)–associated indolent lymphomas with genotype-appropriate direct-acting antivirals (DAAs) with the aim to evaluate virologic and hematologic outcomes. No prospective studies in this setting have been published so far. METHODS FIL_BArT is a prospective, multicenter, phase II trial that evaluated genotype-appropriate DAAs in untreated HCV-positive patients with indolent lymphomas without criteria for immediate conventional antilymphoma treatment. The primary objective was sustained virologic response, whereas the main secondary objectives were overall response rate of lymphoma and progression-free survival. RESULTS Forty patients were enrolled, including 27 with marginal zone lymphoma. Median age was 68 years. Extranodal sites were involved in 14 cases (35%). Main genotypes were 1 in 16 patients and 2 in 21 patients. All patients received genotype-guided DAAs: 17 ledipasvir/sofosbuvir, eight sofosbuvir plus ribavirin, and 15 sofosbuvir/velpatasvir. All patients achieved sustained virologic response (100%). DAAs were well tolerated, with only two grade 3-4 adverse events. Overall response rate of lymphoma was 45%, including eight patients (20%) achieving complete response and 10 (25%) partial response, whereas 16 exhibited stable disease and six progressed. With a median follow-up of 37 months, two patients died (3-year overall survival 93%; 95% CI, 74 to 98) and three additional patients progressed, with a 3-year progression-free survival of 76% (95% CI, 57 to 87). CONCLUSION HCV eradication by DAAs was achieved in 100% of HCV-positive patients with indolent lymphomas not requiring immediate conventional treatment and resulted in non-negligible rate of lymphoma responses. Treatment with DAAs should be considered as the first-line therapy in this setting.
A New Perspective on Regulation of Pituitary Plasticity: The Network of SOX2-Positive Cells May Coordinate Responses to Challenge
Authors: Le Tissier Paul R , Murray Joanne F , Mollard Patrice 
Published: June 2022

AbstractPlasticity of function is required for each of the anterior pituitary endocrine axes to support alterations in the demand for hormone with physiological status and in response to environmental challenge. This plasticity is mediated at the pituitary level by a change in functional cell mass resulting from a combination of alteration in the proportion of responding cells, the amount of hormone secreted from each cell, and the total number of cells within an endocrine cell population. The functional cell mass also depends on its organization into structural and functional networks. The mechanisms underlying alteration in gland output depend on the strength of the stimulus and are axis dependent but in all cases rely on sensing of output of the functional cell mass and its regulation. Here, we present evidence that the size of pituitary cell populations is constrained and suggest this is mediated by a form of quorum sensing. We propose that pituitary cell quorum sensing is mediated by interactions between the networks of endocrine cells and hormone-negative SOX2-positive (SOX2+ve) cells and speculate that the latter act as both a sentinel and actuator of cell number. Evidence for a role of the network of SOX2+ve cells in directly regulating secretion from multiple endocrine cell networks suggests that it also regulates other aspects of the endocrine cell functional mass. A decision-making role of SOX2+ve cells would allow precise coordination of pituitary axes, essential for their appropriate response to physiological status and challenge, as well as prioritization of axis modification.
Do Internal Migration Experiences Facilitate Migration Intentions and Behavior?
Authors: Bernard Aude , Kalemba Sunganani , Nguyen Toan 
Published: June 2022

Abstract
Growing evidence suggests that internal migration experience shapes future internal migration behavior. However, it remains unclear what stage of the decision-making process past internal migration facilitates and whether the impact depends on the distance moved. To advance understanding of the role of past migration, we explicitly and dynamically link migration experiences to the formation and realization of future internal migration intentions by blending the aspiration–ability framework with the learned behavior hypothesis. We empirically test our proposition by fitting a series of logistic regression models to longitudinal microdata from the Household, Income and Labour Dynamics in Australia (HILDA) Survey, which has been conducted annually since 2001. We use a two-step approach by first modeling internal migration intentions and then modeling the realization of these intentions, distinguishing between residential moves, onward interregional migration, and return interregional migration. We find that migration experience is positively associated with both the formation and realization of migration intentions and that the effect of past migration increases with the distance moved and the number of past migrations. These findings suggest that migration experiences accumulate over the life course to predispose individuals toward subsequent migration. Finally, we show that the effect of past migration is not the result of a lack of social capital among repeat migrants—a finding that reinforces the importance of conceptualizing internal migration as a life course trajectory rather than a series of discrete events.
Trans as Brain Intersex
Authors: Wang Thelma 
Published: June 2022

Abstract
There is an abundance of neuroscientific research seeking to pin down the origins of transgender people's gender identity in the brain. The established premise is that transgender people have a brain structure more in line with the sex group with which they identify than the one they are assigned to at birth. Transgender is imagined as a form of intersexuality—but of the brain, rather than the genitalia. This article aims to critically interrogate the neuroscientific notion of transgender as brain intersex by situating the neuroscientific understanding of trans people within the genealogy of the medical management of transgender and intersex people. The study also examines how medical authority consolidates itself through the “trans-intersex nexus”—a mechanism in which trans and intersex people are placed in a relationship of simultaneous separation and reinforcement under the control of medical knowledge and technologies.
Intersex Justice Pedagogy
Authors: Lewis Mel Michelle 
Published: June 2022

Abstract
This article coins the term Intersex Justice Pedagogy and outlines this practice as a decolonial and intersectional teaching and learning praxis that affirms bodily integrity and bodily autonomy as the practice of liberation for intersex people of color. The author examines the personal, political, and pedagogical exigency for a pedagogy that centers voices from overlapping and interlocking intersex, queer, trans, nonbinary, and feminist communities of color, and takes a critical approach to examining paradigms of power, sovereignty, and “the science of sex” in a social world. Using specific examples of texts and approaches to teaching and learning, this article inspires an examination of pedagogical approaches, not only to teaching intersex and trans studies, but also to teaching social justice, with an emphasis on bodily autonomy and bodily integrity from multiple disciplinary/interdisciplinary locations and perspectives.
Ethylene signaling increases reactive oxygen species accumulation to drive root hair initiation in Arabidopsis
Authors: Martin R. Emily , Marzol Eliana , Estevez Jose M. , Muday Gloria K. 
Published: June 2022

ABSTRACT
Root hair initiation is a highly regulated aspect of root development. The plant hormone ethylene and its precursor, 1-amino-cyclopropane-1-carboxylic acid, induce formation and elongation of root hairs. Using confocal microscopy paired with redox biosensors and dyes, we demonstrated that treatments that elevate ethylene levels lead to increased hydrogen peroxide accumulation in hair cells prior to root hair formation. In the ethylene-insensitive receptor mutant, etr1-3, and the signaling double mutant, ein3eil1, the increase in root hair number or reactive oxygen species (ROS) accumulation after ACC and ethylene treatment was lost. Conversely, etr1-7, a constitutive ethylene signaling receptor mutant, has increased root hair formation and ROS accumulation, similar to ethylene-treated Col-0 seedlings. The caprice and werewolf transcription factor mutants have decreased and elevated ROS levels, respectively, which are correlated with levels of root hair initiation. The rhd2-6 mutant, with a defect in the gene encoding the ROS-synthesizing RESPIRATORY BURST OXIDASE HOMOLOG C (RBOHC), and the prx44-2 mutant, which is defective in a class III peroxidase, showed impaired ethylene-dependent ROS synthesis and root hair formation via EIN3EIL1-dependent transcriptional regulation. Together, these results indicate that ethylene increases ROS accumulation through RBOHC and PRX44 to drive root hair formation.
Rewards and recognition for Canadian distributed medical education preceptors: a qualitative analysis
Authors: Bell Amanda , Johnston Aaron , Makwarimba Edward , Malhi Rebecca 
Published: June 2022

Background: Recognition of Distributed Medical Education (DME) preceptors by medical schools ensures that important community-based training opportunities remain available to learners. Yet the literature seldom explores what rewards are meaningful to this population of teachers. The goal of our national project was to provide guidance to medical schools about the financial remuneration and non-financial rewards that are most valued by DME preceptors. Methods: In this qualitative study, we invited DME faculty members from all Canadian medical schools to participate in semi-structured interviews. Participants with a range of medical specialties, stages of career, and geographic locations were interviewed via Zoom videoconferencing. The sessions in English and French were audio-recorded and transcribed. We used line-by-line inductive coding and thematic analysis to examine participant talk about meaningful preceptor recognition. Results: Fourteen participants from multiple provinces were interviewed. Results indicated that the DME faculty are a diverse group of people with diverse needs. Most of the interviewees appreciated the rewards and recognition provided by their medical schools but felt that there are areas for improvement. Recognition is not necessarily monetary and should be tailored to the needs and the values of the recipient. Other themes included: benefits and challenges of being a preceptor, current institutional structures and supports, and the impact of the pandemic on preceptors. Conclusions: The interviews highlighted the importance placed by preceptors on personal rewards and a wide variety of forms of recognition. Based on the findings, we suggest specific steps that medical schools can take to support, engage, and recognize DME faculty.
The Influence of Modern Trends in the Development of the Creative Economy on the Education System
Authors: Vakhorina Marina 
Published: June 2022

The need for research is caused by the influence of the development of modern trends in the creative economy (knowledge economy) on the education system. The aim of the study is to develop the theoretical provisions of the innovative format of education in the conditions of the information and creative economy. Based on the goal, the tasks of the study were determined and solved: an analysis was made of the essence and trends in the development of the creative economy for the formation of skills that a new type of specialist should possess; the influence of technological trends on the labor market is revealed in order to use the promising landscape of creative professions.
The article systematizes the review of the terms "creative economy" and "creative industries", used in professional literature and in normative sources. The historical aspects of the post-industrial development of the economy in Russia from mass production to personal production are revealed based on the requirements for human resources. The study used methods of comparison, generalization and critical evaluation. The practical significance of the topic is based on the international experience of integration using the Global Innovation Index and the Index of Innovative Cities. Based on the identification of the specifics of the creative economy, the provisions of the Concept for the Development of Creative (Creative) Industries until 2030, promising areas for the creative economy to human resources are identified.
The results obtained are accompanied by elements of scientific novelty: it is proposed to integrate the development trends of the creative economy in order to activate and effectively use the creative human potential, which is an important factor in the stabilization and sustainable development of the modern economy. The results of the study can be used as a theoretical basis for further research on this topic, in the practical activities of entrepreneurs and business owners who work in the field of creative industries, as well as individual research results can be used in the educational process of universities in the preparation of bachelors, masters in various fields.
Analysis of the Main Economic Results and Prospects for the Activities of Special Economic Zones in Russia
Authors: Ryzhov Yu. , Fedorova E. 
Published: June 2022

2022 was a turning point for the Russian economy. In the context of geopolitical risks of full-scale investments, a complete outflow of foreign capital, collapsed value chains, inevitable and future decisions to review the effective management of structural transformations in the economy, reformatting or abandoning the partial effectiveness of development institutions.
In modern realities, an unbiased analysis of the prospects for the operation of special economic zones (SEZs), which are a widely used tool for regional economic development responsible for creating an investment climate, is needed.
This paper assesses the effectiveness of a number of SEZs, outlines the economic root causes of their insufficient budgetary efficiency, presents a point of view on the applicability and functionality of this institution in modern realities, and outlines the problems of state management of structural transformations in the economy using the example of SEZs.
Supplier Audit Information Sharing and Responsible Sourcing
Authors: Ha Albert Y. , Shang Weixin , Wang Yunjie 
Published: June 2022

We develop a game-theoretic model to study the incentive for competing manufacturers to share supplier audit information. Based on the audit information, each manufacturer decides whether to source from a common supplier who has uncertain responsibility violation risk or to switch to a backup supplier who has no responsibility violation risk but charges a higher price. When supplier responsibility violation occurs, some consumers boycott the manufacturers involved. Audit information allows a manufacturer to reduce the uncertainty about the risk of the common supplier. We show that audit information sharing may make the manufacturers’ sourcing strategies more or less differentiated. As a result, the information-sharing decision is not monotone in the model parameters. We fully characterize the manufacturers’ equilibrium audit information-sharing and sourcing decisions and establish conditions under which audit information sharing induces the manufacturers to adopt more or less responsible sourcing strategies. We also show that a manufacturer could be better off when the cost premium of sourcing from the backup supplier or the risk of the common supplier becomes higher or the audit information becomes less accurate. We consider several extensions of the base model and demonstrate that the main insights remain mostly valid.This paper was accepted by Charles Corbett, operations management.Funding: A. Y. Hawas supported by the Wei Lun Foundation. W. Shang was supported by the Research Grants Council of Hong Kong [GRF Project LU 13501415]. Y. Wang was supported by National Natural Science Foundation of China [Grant 71901209].Supplemental Material: The online appendix is available at https://doi.org/10.1287/mnsc.2022.4358 .
Correlation properties of a spatially quasi-incoherent imaging interferometer
Authors: Dembele Vamara , Wahl Joel , Sjödahl Mikael , Ramser Kerstin 
Published: June 2022

The depth-gating capacity of a spatially quasi-incoherent imaging interferometer is
investigated in relation to the 3D correlation properties of
diffraction field laser speckles. The system exploits a phase-stepped
imaging Michelson-type interferometer in which spatially
quasi-incoherent illumination is generated by passing an unexpanded
laser beam through a rotating diffuser. Numerical simulations and
optical experiments both verify that the depth-gating capacity of the
imaging interferometer scales as

λ

/

2

N
A

p
2

, where

λ

is the wavelength of the laser and

N
A

p

is the numerical aperture of the
illumination. For a set depth gate of 150 µm, the depth-gating
capacity of the interferometer is demonstrated by scanning a standard
USAF target through the measurement volume. The results obtained show
that an imaging tool of this kind is expected to provide useful
capabilities for imaging through disturbing media and where a single
wavelength is required.
Toward high-power-density laser-driven lighting: enhancing heat dissipation in phosphor-in-glass film by introducing h-BN
Authors: Sui Ping , Lin Hang , Lin Yue , Lin Shisheng , Huang Jiajing , Xu Ju , Cheng Yao , Wang Yuansheng 
Published: June 2022

In this work, hexagonal boron nitride (h-BN) nanocrystals as functional additives in a phosphor-in-glass film are shown to substantially increase the luminous performance driven by a blue laser. Microstructural and spectroscopic studies reveal that h-BN particles distributed over the whole glass matrix build in situ a local heat conductive path which effectively accelerates heat dissipation and so greatly relieves the “thermal run-away effect”. The developed composite material with fine thermal manipulation may be a promising phosphor color converter for high-power-density laser-driven lighting.
Affordable artificial intelligence-based digital pathology for neglected tropical diseases: A proof-of-concept for the detection of soil-transmitted helminths and Schistosoma mansoni eggs in Kato-Katz stool thick smears
Authors: Ward Peter , Dahlberg Peter , Lagatie Ole , Larsson Joel , Tynong August , Vlaminck Johnny , Zumpe Matthias , Ame Shaali , Ayana Mio , Khieu Virak , Mekonnen Zeleke , Odiere Maurice , Yohannes Tsegaye , Van Hoecke Sofie , Levecke Bruno , Stuyver Lieven J. 
Published: June 2022

BackgroundWith the World Health Organization’s (WHO) publication of the 2021–2030 neglected tropical diseases (NTDs) roadmap, the current gap in global diagnostics became painfully apparent. Improving existing diagnostic standards with state-of-the-art technology and artificial intelligence has the potential to close this gap.Methodology/Principal findingsWe prototyped an artificial intelligence-based digital pathology (AI-DP) device to explore automated scanning and detection of helminth eggs in stool prepared with the Kato-Katz (KK) technique, the current diagnostic standard for diagnosing soil-transmitted helminths (STHs;Ascaris lumbricoides,Trichuris trichiuraand hookworms) andSchistosoma mansoni(SCH) infections. First, we embedded a prototype whole slide imaging scanner into field studies in Cambodia, Ethiopia, Kenya and Tanzania. With the scanner, over 300 KK stool thick smears were scanned, resulting in total of 7,780 field-of-view (FOV) images containing 16,990 annotated helminth eggs (Ascaris: 8,600;Trichuris: 4,083; hookworms: 3,623; SCH: 684). Around 90% of the annotated eggs were used to train a deep learning-based object detection model. From an unseen test set of 752 FOV images containing 1,671 manually verified STH and SCH eggs (the remaining 10% of annotated eggs), our trained object detection model extracted and classified helminth eggs from co-infected FOV images in KK stool thick smears, achieving a weighted average precision (± standard deviation) of 94.9% ± 0.8% and a weighted average recall of 96.1% ± 2.1% across all four helminth egg species.Conclusions/SignificanceWe present a proof-of-concept for an AI-DP device for automated scanning and detection of helminth eggs in KK stool thick smears. We identified obstacles that need to be addressed before the diagnostic performance can be evaluated against the target product profiles for both STH and SCH. Given that these obstacles are primarily associated with the required hardware and scanning methodology, opposed to the feasibility of AI-based results, we are hopeful that this research can support the 2030 NTDs road map and eventually other poverty-related diseases for which microscopy is the diagnostic standard.