bluuebunny/crossref_metadata_2025_split huggingface dataset:
Contribution of computerization in the governance of Hospital structures : case of two Hospital Establishments in Mali
Authors: Dembélé Oumar , Bagayoko Cheick Oumar 
Published: December 2022

Abstract
Introduction
The place of information and communication technologies is well established in improving the quality of patient care.
While it is common ground that computerization brings added value in terms of health care, it is important to get a fairly precise idea of its contribution to hospital governance.
The study focused on two establishments:
- The National Center for Odonto-Stomatology (CNOS)
- The “Luxembourg” Mother-Child Hospital (MCH)
Objective
Determine the level of governance indicators before and after computerization
Method
This is a cross-sectional study to be evaluative to determine the contribution of computerization in the governance of the hospital. This contribution was determined by comparing the level of certain quality indicators before and after computerization. It took place from January 2016 to June 2019
Results
After computerization, the study showed that the out-of-stock rate of tracer drugs and consumables decreased by 94% at the MCH; Patient record keeping adequacy rate increased by 100% at CNOS and 62% at Children's; The average length of stay decreased by 70% at CNOS and 25% at the Children's; The user satisfaction rate increased by 19% at CNOS and 7% at the MCH.
Discussion
After computerization, the study showed that the out-of-stock rate of tracer drugs and consumables decreased by 94% at the MCH; Patient record keeping adequacy rate increased by 100% at CNOS and 62% at Children's; The average length of stay decreased by 70% at CNOS and 25% at the Children's; The user satisfaction rate increased by 19% at CNOS and 7% at the MCH.
Conclusion
The study clearly shows that computerization has had a contribution to certain indicators of the quality of care. The shortage rate of drugs and tracer consumables to be reduced by 94% at the Children's Hospital; Patient record keeping adequacy rate increased by 100% at CNOS and 62% at Children's; The average length of stay decreased by 70% at CNOS and 25% at the Children's; The user satisfaction rate increased by 19% at CNOS and 7% at the MCH.
Flexible Group Fairness Metrics for Survival Analysis
Authors: Sonabend Raphael , Pfisterer Florian , Mishler Alan , Schauer Moritz , Burk Lukas , Mukherjee Sumantrak , Vollmer Sebastian 
Published: December 2022

Abstract
Purpose: Algorithmic fairness is an increasingly important field concerned with detecting and mitigating biases in machine learning models. There has been a wealth of literature for algorithmic fairness in regression and classification however there has been little exploration of the field for survival analysis. Survival analysis is the prediction task in which one attempts to predict the probability of an event occurring over time. Survival predictions are particularly important in sensitive settings such as when utilising machine learning for diagnosis and prognosis of patients.
Methods: In this paper we explore how to utilise existing survival metrics to measure bias with group fairness metrics. We explore this in an empirical experiment with 29 survival datasets and 8 measures.
Results: We find that measures of discrimination are able to capture bias well whereas there is less clarity with measures of calibration and scoring rules.
Conclusion: We suggest further areas for research including prediction-based fairness metrics for distribution predictions.
How to choose “Good” Samples for Text Data Augmentation
Authors: Lin Xiaotian , Lin Nankai , Fu Yingwen , Yang Ziyu , Jiang Shengyi 
Published: December 2022

Abstract
Deep learning-based text classification models need abundant labeled data to obtain competitive performance. Unfortunately, annotating large-size corpus is time-consuming and laborious. To tackle this, multiple researches try to use data augmentation to expand the corpus size. However, data augmentation may potentially produce some noisy augmented samples. There are currently no works exploring sample selection for augmented samples in nature language processing field. In this paper, we propose a novel self-training selection framework with two selectors to select the high-quality samples from data augmentation. Specifically, we firstly use an entropy-based strategy and the model prediction to select augmented samples. Considering some samples with high quality at the above step may be wrongly filtered, we propose to recall them from two perspectives of word overlap and semantic similarity. Experimental results show the effectiveness and simplicity of our framework.
Microcystin-LR Detection in Freshwater Body by LC-MS/MS: Impediment for Water quality: Case study on Naharkhoran drinking water treatment plant
Authors: Halakoo Cobra , Emtyazjoo Mozhgan , Amoozegar Mohammad Ali , Nowroozi Jamileh , Saravi Hasan Nasrollahzadeh 
Published: December 2022

Abstract
Annual appearance of Microcystis blooming in superficial drinking water sources cause human poisoning in some places in the world, as they enter into DWTP (Drinking Water Treatment Plant) and bring into trouble in some of the water treatment stages. This research investigated attendance of MC-LR (Microcystin-LR) in aggregated samples from Naharkhoran DWTP pre and post-treatment where intake water from Ziarat River, as well as that correlation to some water quality parameters at the same time. Sampling was implemented into three-term (early & end summer and middle of autumn) from three stations: 1 input DWTP (raw water) and 2 output DWTP (pre & post chlorination). MC-LR was analyzed by LC/MS/MS (Liquid Chromatography/tandem Mass Spectrometry), other parameters were assayed by standard analytical methods. This effort is the first case study of MC-LR on Naharkhoran DWTP established downstream of Ziarat River to provide drinking water for Gorgan city residents, Iran. The MC-LR concentration in all of the samples was very low and below recommended national & global values. Fortunately, any MC-LR was observed in output DWTP at chlorinated water samples. Some of the other quality parameters measured below recommended national & global values and any were significant relationships between MC-LR with other parameters except pH which was inverse. Lack of MC-LR in the output of DWTP (treated water) post disinfection representative efficacious treatment and safe water for drinking.
Identifying new driver genes for castration resistance for prostate cancer based on protein mass spectrometry and transcriptome big data
Authors: Liu Wei , Zhou Xiaobei , Zhou Tingting , Zou Renlong , Wang Xiuxia , Liu Wensu 
Published: December 2022

Abstract
Purpose
Androgen is important in the formation, development and progress of prostate cancer. Deprivation of androgen, also named castration, is an effective way in prostate cancer therapies. For patients undergoing castration therapies, castration was gradually becoming ineffective in prostate cancer treatment and therefore resulting in castration resistance for prostate cancer, which is beyond efficient therapies. Moreover, the mechanism on how castration resistance was originated and what promoted castration resistance was rarely reported. We designed the project to further understand the mechanism for castration resistance.
Methods
AR-V7 and PRPF6 were selected to be calibration markers and then performed with protein mass spectrometry to detect AR-V7 and PRPF6 binding proteins. Afterwards, we used transcriptome big data from prostate cancer and castration-resistant prostate cancer and then applied combined analysis of association rules method, gene co-expression analysis, linear matrix migration method and functional deep filtering on identifying candidate driver genes which were causally correlated with castration resistance. The predicted driver genes were intersected with protein mass spectrometry filtering results for both AR-V7 and PRPF6. Afterwards, the predicted driver genes were theoretically and experimentally validated.
Results
The 5 candidate driver genes RPL28, RPS4X, RPL11, RPL23A and RPSA were deemed as driver genes for castration resistance and were validated on being highly correlated and playing important role in the progress of castration resistance.
Conclusion
The new driver genes might assist on further understanding the mechanism and bringing new insight on the prevention and therapy for castration resistance on prostate cancer.
Degradation of the cyanobacterial toxin anatoxin-a by a Bacillus strain in batch culture
Authors: Mohamed Zakaria A. , Mostafa Yasser , Alamri Saad , Hashem Mohamed , Alrumman Sulaiman 
Published: December 2022

Abstract
Anatoxin-a (ATX-a) is an alkaloid neurotoxin produced by certain species of cyanobacteria. It is water soluble and relatively stable in natural water, and thereby could present health hazards to human, animals and plants through prolonged exposure. Conventional water treatment methods are insufficient for ATX-a removal, and sometimes cause cell lysis and release on intracellular toxin. Biodegradation could be a promising method for removal of this toxin. This study addresses for the first time ATX-a biodegradation by Bacillus strain into a nontoxic byproduct (epioxy-ATX-a). The results showed that Bacillus strain AMRI-03 grew without lag phase in a lake water containing ATX-a.The strain also exhibited rapid ATX-a degradation, and the total degradation was initial- toxin-concentration–dependent.Total degradation of ATX-a occurred within 4 days at the highest two initial concentrations (50 & 100µg L− 1), compared to 6 and 7 days at lower concentrations (20, 10, and 1µg L− 1, respectively). Biodegradation rate by this bacterium also depended on initial ATX-a concentration, with highest value (12.5µg ATX L− 1 day− 1) recorded at the highest initial toxin concentrations (50 & 100µg L− 1). ATX-a biodegradation rate was influenced by temperature, with highest occurred at 25 and 30 ºC. pH also affected this rate, and the highest rates were obtained under neutral and slightly alkaline conditions (i.e., pH7 and 8). Both lower and higher pHs slowed the degradation rate. Being nontoxic, this bacterial strain could be applied in slow sand filters for degradation and removal of anatoxin-a in water treatment plants, after setting up mesocosm experiments to assess the potential effects of this bacterium on water quality.
Human papilloma virus profiles in breast cancer in correlation with Vitamin D
Authors: AZMI Hasna , SAIF Imane , NABIL Kawtar , MZIBRI Mohammed EL , BOUTAYEB Saber , ENNAJI Moulay Mustapha 
Published: December 2022

Abstract
The presence of the vitamin D receptor on the surface of breast tissue active results in terminal differentiation and inhibition of cell growth. The implication of vitamin D deficiency on cancer susceptibility found an association between low serum 25(OH) D3 levels and increased prevalence of breast cancer genesis. The risk factors incriminated in the genesis of breast cancer are well known, there is the involvement of certain oncogenic viruses, particularly HPV. In this, study 22 patients with breast cancer with a dosage of vitamin D less than normal with HPV infection. No significance between Clinicopathological parameters and vitamin D assay.
Investigating the Digital Citizenship Levels of ELT Students within the Scope of Remote Learning
Authors: Şenel Müfit 
Published: December 2022

<p><em>It is obvious that using the Internet and technological tools became a ‘must’ throughout the Covid-19 pandemic period. All students and teachers started to use all those tools intensively both in their lessons and at their homes, and this process led to the digitalization of the classrooms and courses. Therefore, information and communication technologies (ICTs) and remote learning spread to all aspects of our lives and led to the emergence of a new concept, namely ‘Digital Citizenship’, making it significant to comprehend where students’ digital competence levels are. In line with this, the objective of this research was to investigate the digital citizenship levels of the participants and how much they are knowledgeable about being conscious digital citizens. Totally, 196 students from an ELT department of a state university in Turkey participated in the study. The study was carried out with a quantitative research method in the 2021-2022 spring semester, and data were collected through the 5-point Likert type “Digital Citizenship Scale”. Responses were evaluated by SPSS v26 statistical package program and based on the findings, it was indicated that almost all dimensions of digital citizenship were met by the participants. Since there was almost no statistically significant in terms of gender, age, and grade variables, the highest dimensions were found at digital commerce and digital responsibility levels</em><em>. </em> <em>This current study will pay the way for educators, instructors, curriculum designers, and materials developers to review, redesign and reevaluate the existing language teaching programs. Students will also be aware of their weaknesses and strengths about digital citizenship and realize the significance of the concept of digital citizenship.</em><em></em></p>
Geografia, (des)interesse e (des)conhecimento em períodos de ultradireita
Authors: Carneiro Rosalvo Nobre 
Published: December 2022

A Geografia se institucionalizou na segunda metade do século XIX, na Alemanha e na França, como uma ciência empírico-analítica. Entre 1950 e 1970 se constituiu como uma ciência histórico-hermeneútica e, em seguida, como uma ciência crítica. No Brasil, o saber geográfico atravessou diferentes períodos históricos marcados pela ultradireita. Diante disso, procura-se interrogar em que medida, com o retorno ao ultraconservadorismo pós-Golpe de Estado de 2015 no Brasil, o interesse emacipatório que orienta as ações na área da Geografia acadêmica e escolar sofre um desinteresse político em detrimento do interesse técnico e atrelado aos seus saberes? Neste contexto, objetiva-se analisar a relação entre interesse e conhecimento da ciência geográfica em períodos de conservadorismo e antidemocracia.Trata-se de pesquisa bibliográfica, considerando-se a periodização das escolas de pensamento geográfico positivista, funcionalista e crítico-marxista. Foca-se nas aproximações entre o papel da Geografia escolar e o desenvolvimento do campo acadêmico da Geografia. Como resultados, verifica-se quanto às duas primeiras escolas de pensamento uma apropriação política do saber espacial mediante interesses técnico para a construção da identidade nacional, da ideologia patriótica e do desenvolvimentismo, no contexto de governos de ultra-direita ditatoriais. Conclui-se, porém, que com o governo de extremadireita eleito democraticamente mediante em 2018, verifica-se um desinteresse pelo conhecimento geográfico academico, isto é do territorio nacional, e um deficit na perspectiva crítica do ensino nas escolas pela via indultora da BNCC.
Da economia circular à ecologia das redes
Authors: Preger Guilherme de Figueiredo 
Published: December 2022

Este artigo aborda a mudança de paradigma para a noção de trabalho na sociedade impactada pela transformação digital. Reformulando o conceito de trabalho como transformação conservadora de energia, de acordo com a primeira lei da termodinâmica, para o entendimento do trabalho como redução da entropia, conforme a segunda lei, é possível compatibilizá-lo com os conceitos de informação e de comunicação. O artigo sugere que esta reformulação já estava implícita na teoria marxista e a diferencia do modelo ricardiano clássico. A transformação digital é pensada como corte epistemológico no modo de produção, que traz consequências para o sistema funcional da economia. Neste, o modo dominante da economia capitalista (o capitalismo de plataforma) é confrontado com modos alternativos como o da Economia Solidária. O artigo examina se a transformação digital traz vantagens comparativas para a Economia Solidária e conclui positivamente neste sentido.
teoria do agir comunicativo de Habermas na administração de organizações
Authors: Lima Clóvis Ricardo Montenegro de , Lima José Rodolfo Tenório , Carvalho Lidiane dos Santos , Sanches Neto Asy Pepe , Titonelli Anderson 
Published: December 2022

Neste artigo mostra-se os resultados de uma busca em bases de dados internacionais sobre a teoria do agir comunicativo de Habermas na área da Administração de Organizações. A teoria de Habermas foi desenvolvida após a sua guinada linguística, de ruptura com a filosofia da consciência e a metafísica em 1981. Nela os usos da linguagem são modos de expressão e representação, mas também modo de construção de vínculos sociais. A partir desta teoria, Habermas desenvolve a ideia de discurso como agir comunicativo orientado para o entendimento, e elabora uma ética do discurso e uma política deliberativa. A entrada da obra de Habermas na Administração antecede a sua guinada linguística, e deve ser destacado o uso da sua tese "Mudança estrutural da esfera pública". Neste artigo quer-se destacar as relações estabelecidas entre a filosofia da linguagem e a Administração, tanto em acordos teóricos quanto práticos. Entre os aspectos teóricos destaca-se os estudos teóricos do conhecimento, incluindo a epistemologia. Entre os aspectos práticos estão as questões da filosofia prática, a ética e a política. Quer-se assim apresentar o potencial da filosofia de Habermas para pesquisa e trabalho na Administração de Organizações.
Analysis of Organizational Commitment and Leadership Style as Moderation Variables in Achieving Managerial Performance
Authors: Nahar Aida 
Published: December 2022

AbstractThis study aims to analyze the moderating variables that affect the managerial performance of furniture companies in Jepara district. Managerial performance is achieved if the planning involves the participation of employees. Management and employees jointly design company plans. Therefore, this study examines whether budgetary participation affects managerial performance. In addition, the moderating variables of organizational commitment and leadership style were investigated in this study to strengthen the influence of budgetary participation on managerial performance. The population of this study was managers and employees of furniture companies in Jepara district, amounting to 77,817.The sampling technique was random sampling method and the technique of data analysis used moderated regression analysis. The result reveals that managerial performance is influenced by budgetary participation if there is organizational commitment and depends on the company's leadership style. Keywords: Budgetaryparticipation; Organizational commitment; Leadership style; and managerial performance Analisis Komitmen Organisasi dan Gaya Kepemimpinan Sebagai Variabel Moderasi dalam Pencapaian Kinerja Manajerial AbstrakPenelitian ini bertujuan untuk menganalisis variabel moderasi yang mempengaruhi kinerja manajerial perusahaan mebel di kabupaten Jepara. Kinerja manajerial tercapai jika perencanaan melibatkan partisipasi karyawan. Manajer dan karyawan bersama-sama merancang rencana perusahaan. Oleh karena itu, penelitian ini mengkaji apakah partisipasi penyusunan anggaran berpengaruh terhadap kinerja manajerial. Selain itu, komitmen organisasi dan gaya kepemimpian diteliti dalam penelitian ini untuk menguji apakah dapat memperkuat pengaruh partisipasi anggaran terhadap kinerja manajerialnya. Populasi dalam penelitian ini adalah manajer dan karyawan perusahaan mebel di kabupaten Jepara yang berjumlah 77.817 orang. Teknik pengambilan sampel menggunakan metode random sampling dan teknik analisis data menggunakan analisis regresi moderasi. Hasil penelitian ini adalah efektivitas bisnis dipengaruhi oleh partisipasi anggaran jika ada komitmen organisasi dan tergantung pada gaya kepemimpinan perusahaan Kata kunci: Partisipasi Anggaran, Komitmen Organisasi, Gaya Kepemimpinan, dan Kinerja Manajerial
A Comprehensive Review: Transdermal Drug Delivery System: A Tool For Novel Drug Delivery System
Authors: Sadab Sadab , Sahu Sarad , Patel Shubham , Khan Rubeena , Khare Basant , Thakur Bhupendra Singh , Jain Anushree , Jain Prateek Kumar 
Published: December 2022

In the recent decade, skin delivery (topical and transdermal) has gained an unprecedented popularity, especially due to increased incidences of chronic skin diseases, demand for targeted and patient compliant delivery and interest in life cycle management strategies among pharmaceutical companies. Transdermal drug delivery system was presented to overcome the difficulties of drug delivery especially oral route. Transdermal drug delivery refers to a means of delivering drugs through the surface of the skin for local or systemic treatment. The drug functions after absorption through the skin into the systemic circulation via capillary action at a certain rate. Transdermal patches are now widely used as cosmetic, topical and transdermal delivery systems. These patches represent a key outcome from the growth in skin science, technology and expertise developed through trial and error, clinical observation and evidence-based studies that date back to the first existing human records. A transdermal patch is a medicated adhesive patch that is placed on the skin to deliver a specific dose of medication through skin and into the bloodstream. An advantage of a transdermal drug delivery route over other types of delivery system such as oral, topical, intravenous (i.v.), intramuscular (i.m.), etc. is that the patch provides a controlled release of the medication into the patient, usually through either a porous membrane covering a reservoir of medication or through body heat melting thin layers of medication embedded in the adhesive. The main disadvantage to transdermal delivery systems stems from the fact that the skin composition offers very effective barrier that allow only small molecule based drugs to penetrate the skin and pass through the barrier. Sildenafil citrate (SLD) is a selective cyclic guanosine monophosphate-specific phosphodiesterase type 5 inhibitor used for the oral treatment of erectile dysfunction and more recently, it has been used for the treatment of pulmonary arterial hypertension and the enhancement of uteroplacental perfusion in case of fetal growth retardation. The challenges facing the oral administration of the drug include poor bioavailability and short duration of action that requires frequent administration. The main objective of transdermal drug delivery system is to deliver drugs into systemic circulation through skin at predetermined rate with minimal inter and intrapatient variations.
Keyword: Skin delivery, Transdermal drug delivery, Oral rout, Sildenafil citrate, Pulmonary arterial hypertension
Analisis Karakter Cinta Tanah Air Melalui Novel Berjudul "Hatta: Aku Datang Karena Sejarah
Authors: Azizah Ifah , Wahyuni Anny , Purnomo Budi 
Published: December 2022

Mohammad Hatta merupakan seorang tokoh penting bagi kemerdekaan Indonesia. Peran dan pemikiran Mohammad Hatta adalah salah satu yang paling melekat dari pemimpin bangsa Indonesia lainnya, baik dibidang sosial, politik maupun ekonomiMohammad Hatta adalah seorang tokoh pergerkan nasional indonesia yang memiliki pengetahuan luas di bidang sosial, politik, dan ekonomi Indonesia. Nasionalisme Mohammad Hatta yaitu berdasarkan konsep kedaulatan rakyat memiliki arti, yaitu kekuasaan tertinggi di tangan rakyat, dan dilaksanakan dikendalikan oleh dewan yang dipilih oleh rakyat, demi rakyat, Konsep kedaulatan memiliki poin-poin demokrasi di bidang politik dan ekonomi. Aktualisasi Mohammad Hatta pandangan kebangsaan yang tertuang dalam pasal-pasal UUD 1945 dan asas-asasnya Pancasila yang memuat ketetapan nilai ketuhanan sebagai landasan moral Indonesia. nilai-nilai kemanusiaan, nasionalisme berbagai aliran, cita-cita keadilan filosofis, politik dan sosial untuk kesejahteraan rakyat.
Penelitian ini adalah penelitian kualitatif dengan menggunakan metode history atau metode sejarah dengan pendekatan studi pustaka, penelitian ini bertujuan untuk menganalisis karakter cintah tanah air melalui novel yang berjudul “Hatta: Aku Datang Karena Sejarah”