bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dynamic Cardiac Computed Tomography Characteristics of Double-Chambered Right Ventricle
Authors: Chang Monal Yu-Hsuan , Liou Yan-De , Huang Jou-Hsuan , Su Chia-Hung , Huang Shu-Chien , Lin Ming-Tai , Chen Shyh-Jye 
Published: September 2022

Abstract
PURPOSE: To introduce image characteristics of double-chambered right ventricle on cardiac computed tomography and set a diagnostic criterion for the diagnosis.
METHODS: We retrospectively collected and measured the right ventricular constrictive ratio on computed tomography images in children who had simple ventricular septal defects in the past 10 years, because double-chambered right ventricle is often associated with ventricular septal defects. The right ventricular constrictive ratio was defined as the subinfundibular cross-sectional intraluminal area during end-systole divided by the area during end-diastole in the same patient.
We compared the right ventricular constrictive ratio between subjects with concomitant double-chambered right ventricle and those without.
RESULTS: 52 children were included, and 23 (44.2%) of them have concomitant double-chambered right ventricle. In most cases (n=21; 91.3%), the hypertrophied muscular bundles occur just inferior to the level of the supraventricular crest in the right ventricle. Mean right ventricular constrictive ratio in patients with double-chambered right ventricle (15%) was significantly smaller than that without (29%). A cut-off value of a right ventricular constrictive ratio less than 20.1 % was established to diagnose double-chambered right ventricle with an 89.7% sensitivity and 78. 3% specificity.
CONCLUSION: Right ventricular constrictive ratio can be a valuable asset for the preoperative diagnosis of double-chambered right ventricle with cardiac computed tomography.
Assessment of the relationships between Ki67 expression and neoadjuvant treatment response and prognosis in breast cancer using two types of response evaluation systems
Authors: Sullu Yurdanur , Demirag Guzin , Kuru Bekir , Ozen Necati , Karagoz Filiz 
Published: September 2022

Abstract
Background: Although it is not a good prognostic marker for all breast cancers, pathological complete response (pCR) is an endpoint in evaluating neoadjuvant chemotherapy (NAC) efficacy. Ki67, a proliferation marker, has a complex role as a predictive marker in determining the NAC response. This study aimed to investigate the relationship between pretreatment and posttreatment Ki67 levels, posttreatment Ki67 change and treatment response using the Miller–Payne (MP) and Residual Cancer Burden (RCB) response assessment systems.
Methods: A total of 178 invasive breast carcinoma patients who underwent NAC were included in the study. Ki67 levels were evaluated by immunohistochemical method in trucut biopsy and surgical excision specimens. Treatment response in the surgical excision specimen was classified according to both MP and RCB classifications. We investigated the relationships between pretreatment Ki67 level, posttreatment Ki67 level and posttreatment change in Ki67 with NAC response and survival. Additionally, the cut-off value of the pretreatment Ki67 level for pCR and nonpathological response (pNR) was investigated.
Results. The pretreatment Ki67 level was significantly higher in the pCR group than in the partial response (pPR) and pNR groups (p<0.001) in both the MP and RCB systems. The posttreatment Ki67 level was significantly higher in the pNR group than in the pPR group (p<0.001) in both systems. There was a negative correlation between pretreatment Ki67 and disease-free survival (DFS) in the luminal B HER2-negative subtype (r=-0.377, p=0.036) and a significant negative correlation between posttreatment Ki67 and overall survival (OS) in the HER2-positive subtype (r=-0.544, p= 0.0209). A significant correlation was found between the posttreatment Ki67 change and the degree of response in the luminal B HER2-positive and HER2-positive subtypes (p<0.05). The Ki67 cut-off value was 37.5 for pCR in both the MP and RCB classification systems (95% CI 0.673-0.833 and 95% CI0.66-0.827) (p<0.001). There was a significant moderate agreement between the MP and RCB systems (p<0.001).
Conclusions: Pre-and posttreatment Ki67 levels may be used to assess treatment response in various molecular subtypes of breast cancer. In this study, the cut-off value of Ki67 for pCR was 37%. More aggressive treatments may be considered in luminal B HER2-negative tumours with high pretreatment Ki67 levels and tumours that do not show a Ki67 decrease.
Architecture characterization of orchard trees for mechanical behavior investigations
Authors: Jeon Min-Kyung , Burrall Matthew , Kwon Tae-Hyuk , DeJong Jason , Martinez Alejandro 
Published: September 2022

Abstract
Background
Statistical analysis of root architectural parameters is necessary for development and exploration of root structure representations and their resulting anchorage properties. Three-dimensional (3D) models of orchard tree root systems, Lovell (from seed, prunus persica), Marianna (from cutting, prunus cerasifera), Myrobalan (from cutting, also prunus cerasifera), that were extracted from the ground by vertical pullout are reconstructed through photogrammetry, and then skeletonized as nodes and root branch segments. Combined analyses of the 3D models and skeletonized models enable detailed examination of basic bulk properties and quantification of architectural parameters divided into simple root segment classifications— trunk root, main lateral root, and remaining roots.
Results
The patterns in branching and diameter distributions show significant difference between the trunk and main laterals versus the remaining lateral roots. In general, the branching angle decreases with branching order. The main lateral roots near the trunk show significant spreading while the lateral roots near the end tips grow roughly parallel to the parent root. For branch length, the roots branch more frequently near the trunk than further from the trunk. The root diameter decays at a higher rate near the trunk than in the remaining lateral roots, while the total cross-sectional area across a bifurcation node remains mostly conserved. The histograms of branching angle, and branch length and thickness gradient can be described using lognormal and exponential distributions, respectively.
Conclusions
Statistical measurements of root system architecture upon hierarchy provide a basis for representation and exploration of root system structure. This unique study presents data to characterize mechanically important structural roots, which will help link root architecture to the mechanical behaviors of root structures.
Efficacy and safety analysis of a new hemostatic gelatin matrix for spinal surgery: A randomized controlled study
Authors: Gao Ran , Yang Xiaowei , Zhang Bi , xu jiaqiang , Liang Wen , Xie Banglin , Zhang Bin , Guo Runshegn , Lai Qi 
Published: September 2022

Abstract
Objective
This study aimed to assess the efficacy and safety of a new hemostatic gelatin matrix for use in spinal surgery.
Methods
From September to December 2020, 54 patients from our hospital were recruited and randomly allocated to a test group or a control group using computer-generated randomization codes. In the test group, the new hemostatic gelatin matrix was used; in the control group, the Surgiflo™ Hemostatic Matrix was used. All operations for both groups were performed by a senior physician, and the following measures were recorded for comparison: (i) rates of successful hemostasis at 5 min; (ii) time to hemostasis; (iii) blood pressure (BP); (iv) red blood (RBC) cell count; and (v) hemoglobin (Hb) levels in the preoperative period, 1st to 2nd postoperative days, and 42nd postoperative day. Adverse events following surgery were also compared.
Results
All patients were followed up for at least 6 weeks. In the test group, 24 and 2 cases achieved and did not achieve hemostasis within 5 min, respectively. In the control group, 23 and 2 cases achieved and did not achieve hemostasis within 5 min, respectively. There was no statistical difference between the two groups (P = 0.967). The time to hemostasis, BP, RBC, and Hb in the preoperative period, on the 1st and 2nd postoperative days, and 42nd postoperative day also showed no significant differences between groups (P > 0.05).
Conclusion
The new hemostatic gelatin matrix has the same efficacy and safety as that of Surgiflo™ Hemostatic Matrix.
Prognostic significance and biological function of SOCS3 in bladder cancer
Authors: Zhou Hui , Chen Liuxi , Liu Ying , Zhang Ruonan , Chen Bi , Feng Jiao , Liu Shuiping , Xiang Yu , Zhang Mingming , Duan Ting , Zhang Wenzheng , Tang Huifen , Yang Zuyi , Chen Xiaohui , Gu Lei , Zhang Qi 
Published: September 2022

Abstract
Background: Suppressor of cytokine signaling (SOCS) is a family of proteins that respond to cytokine, growth factors and other signals, and can regulate various functions of tumor cells. The purpose of our study was to investigate the prognostic performance and biological function of SOCS3 in bladder cancer.
Methods: The clinical information of 80 patients with bladder cancer at Zhejiang Provincial People’s Hospital was collected and the SOCS3 protein level was detected by immunohistochemistry. The relationship between SOCS3 status and clinical parameters and the prognosis was analyzed. Besides, we explored the biological function of SOCS3 in bladder cancer.
Results: The expression of SOCS3 in bladder cancer tissues was lower than that in normal tissues at the protein level and transcription level (P < 0.001). The low expression group of SOCS3 was more inclined to high staging and high grading. The prognosis of the high expression group of SOCS3 was significantly better than that of the low expression group of SOCS3 in non-muscle-invasive bladder cancer patients (P = 0.037). Also, ectopic expression of SOCS3 reduced the cell proliferation and migration ability of the bladder cancer cell line.
Conclusions: Our findings imply that SOCS3 is a potential prognostic factor for non-muscle-invasive bladder cancer, and plays a tumor suppressor role in bladder cancer.
The Effect of Parental Diabetes Prevention Program Participation on Weight Loss in Dependent Children: A Prospective Cohort Study
Authors: Atluri Namratha , Thariath Joshua , McEwen Laura N. , Ye Wen , Song MinKyoung , Herman William H. 
Published: September 2022

Abstract
Introduction: Obesity has reached epidemic proportions in children and adolescents in the United States. Children’s behaviors are strongly influenced by parental behaviors, and weight loss in parents is positively associated with weight changes in their overweight/obese children. Research is limited on how parents’ National Diabetes Prevention Program (DPP) participation affects the health outcomes of their dependent children. Analyzing the impact of parental DPP participation on weight loss in their dependent children may provide valuable insight into an important secondary benefit of DPP participation.
Methods: In this study, we identified 128 adults with prediabetes who were offered the opportunity to participate in a DPP (n = 54 DPP participants and n = 74 DPP non-participants) and who had at least one child 3 to 17 years of age living with them. Age and BMI percentile for dependent children were collected from insurance claims data for 203 children (n = 90 children of DPP participants and n = 113 children of DPP non-participants). Children’s changes in diet and physical activity, as assessed by parental surveys, were reported as secondary outcomes.
Results: There were no significant changes in BMI percentiles of overweight or obese children (i.e. BMI percentile ≥ 50%) of DPP participants vs DPP non-participants with prediabetes over one-year. Parents who enrolled and did not enroll in the DPP did not differ in the advice they reported giving to their children about eating a healthy diet or engaging in regular physical activity.
Discussion: These results are not consistent with the literature that suggests parent-based interventions may influence their children’s weight trajectories. Limitations include small sample size, short time span of intervention, and limited availability of additional health/biographic data on dependent children. Future studies should collect primary outcome data on children, investigate whether there is a minimum duration of parental involvement and level of parental adherence, and assess the effect of parent-child dynamics on child weight trajectories.
Human Wharton’s jelly-derived mesenchymal stem cells prevent pregnancy loss in a rat by JAK/STAT-mediated immunomodulation
Authors: Ding Xiaoying , Wu Rongrong , Yang Tingting , Jin Beibei , Zhu Chunyu , Zhang Yuquan , yang Xiaoqing 
Published: September 2022

Abstract
Spontaneous abortion (SA) is a syndrome with many origins. Among them, immune imbalance is a major risk factor for SA. Wharton's jelly-mesenchymal stem cells (WJ-MSCs) are considered to be able to prevent abortion. However, the underlining molecular signaling pathways and regulatory mechanisms of WJ-MSCs in pregnancy maintenance are poorly understood. Here abortion mode is established by subcutaneous injection of bromocriptine in rat on day 9 and abortion prevention is achieved by WJ-MSCs injection via tail vein with or without JAK/STAT inhibitor. Here, we show that WJ-MSCs significantly lower the rate of embryo resorption of spontaneous abortion by reducing Th1-related cytokines while increasing Th2 and Th3-related cytokines in JAK/STAT-dependent manner. Together, our observation of WJ-MSCs in spontaneous abortion prevention will shed new light on potential therapeutic strategy development.
Study on the correlation mechanism between the living vegetation volume of urban road plantings and PM2.5 concentrations
Authors: Qianqian Sheng , Anqi Dai , Huihui Zhang , Zunling Zhu 
Published: September 2022

Abstract
To study the effects of species diversity of different urban road green space on PM2.5 reduction, and to provide a theoretical basis for the optimal design of urban road plantings. Different combinations of road plantings in Xianlin Avenue of Nanjing were used as sample areas, and 3–6 PM2.5 monitoring points were set up in each sample area. The monitoring points were setup at 10, 20, 30, 40, 50, and 60 m from the roadbed for detecting PM2.5 concentrations in different sample areas. Moreover, the living vegetation volume of each sample area was calculated. The coupling relationship between the living vegetation volumes and PM2.5 concentrations in different sample areas was evaluated by regression fitting and other methods. PM2.5 concentrations among different sample areas were significantly different. PM2.5 concentrations were higher in the morning than in the afternoon, while the differences were not significant. The living vegetation volumes of the eight sample areas varied from 2038.73 m3 to 15032.55 m3. Affected by different plant configurations, the living vegetation volumes in the sample areas showed obvious differences with an order of S7 > S2 > S3 > S1 > S5 > S6 > S8 > S4. The S2 sample area, which was considered as control, was inside a residential area. The fitting curve of living vegetation volumes and PM2.5 concentrations in sample areas of S1 and S3–S8 can explain 76.4% of the change in PM2.5 concentrations, which showed significant fitting. The fitting relationship between living vegetation volumes and PM2.5 concentrations in different road green space is different owing to different compositions of plantings. With the increase in living vegetation volumes, their fitting functions first increase and then decrease in a certain range. It is speculated that only when the living vegetation volume exceeds a certain range, it will promote PM2.5 reduction.
A Mediterranean-Style Diet in association with gastroesophageal reflux disease in adolescents
Authors: AhmadiVasmehjani Azam , Beigrezaei Sara , Nafei Zahra , Behniafard Nasrin , Aflatoonian Majid , Darabi Zahra , Salehi-Abargouei Amin 
Published: September 2022

AbstractBackground: Gastroesophageal reflux disease (GERD) is one of common esophageal diseases in adolescents. Recent evidence has shown that dietary patterns might be associated with GERD risk. The aim of this study was to assess the association between a Mediterranean style diet (MedDiet) and GERD in a large sample of adolescents living in central Iran.Methods: This cross-sectional study conducted on 5141 adolescents aged between 13-14 years. Dietary intake assessed by using a food frequency method. The GERD diagnosed using a six-item questionnaire, which askes about its symptoms including heartburn, sense of reflux, poor sleep, medication use, nausea and epigastric pain. A binary logistic regression used to evaluate the relationship between the MedDiet score and GERD and its associated symptoms.Results: The analyses revealed that after adjustment for all possible confounding variables, the adolescents in the highest adherence to the MedDiet score had lower odds of GERD [odds ratio (OR)= 0.53; 95% CI 0.35-0.80, Ptrend = 0.005)], sense of reflux (OR= 0.45; 95 % CI 0.26-0.77, Ptrend = 0.01) and poor sleep (OR= 0.54; 95% CI 0.31-0.96, Ptrend = 0.02) compared with those in the lowest adherence. This association remained significant after adjustment for confounding factors including of age, sex, watching TV and computer and BMI. No significant link found betweenMedDiet and other GERD symptoms.Conclusion: The present study reported an inverse association between adherence to a Mediterranean style diet and GERD among Iranian adolescents. Adherence to MedDiet may be an important strategy in preventing GERD in adolescents.
Small Scale Biogas Technology Adoption Behaviours of Rural Households and its Effect on Major Crop Yields in East Gojjam Zone of Ethiopia: Propensity Score Matching Approach
Authors: Chekol Fasika , Tsegaye Ashebir , Mazengia Teshager 
Published: September 2022

Abstract
The objective of this study was to identify and assess the main determinants of small-scale biogas technology adoption and its effect on crop yields. The case study is based on cross-sectional data collected from 335 rural households in the East Gojjam Zone of Ethiopia. Both primary and secondary data were used for this study. Primary data were collected through a questioner-based survey from 197 biogas adopter (treated) and 138 non-adopter (control) households. The analysis was based on propensity score matching (PSM) methods to estimate the determinants and impact of biogas technology adoption on cereal crop yields. Estimates from the probit model indicate that cattle head, follow-up and support, extension contact, training access, distance to water sources, and distance to the market were the main determinants of the adoption of biogas technology. The comparison between adopters and non-adopters based on PSM reveals that the adopters and users of bio-slurry significantly increase the crop yields by 41.5quintal/year/household on average. In summary, PSM estimation confirms that users of biogas slurry had a positive and significant impact on crop yields. Agricultural and rural development policies of Ethiopia should consider the impact of biogas technology adoption behavior of households when devising policy actions within the Agricultural Transformation Plan.
Landau-Khalatnikov Subcircuit based Equivalent Circuit Model for Hybrid Perovskite Solar Cells
Authors: Pavu Kiran Susan , Jacob Jobymol 
Published: September 2022

Abstract
Hybrid perovskite solar cell technology has a distinct advantage over the conventional solar cell technologies due to its high predicted efficiency and low manufacturing cost. However, its commercialization is hindered by the unpredictability existing in its J-V characteristics leading to ambiguous efficiency estimation. Modeling the hysteresis in the J-V characteristics is a means of curtailing this ambiguity. It is established in literature that hysteresis models can be derived from the non-linear behavior of ferroelectric materials. Perovskite, which forms the light absorbing region of the solar cell is a ferroelectric material. In this paper, an equivalent circuit model for the hybrid perovskite solar cell is proposed in which the reasons for origin of hysteresis is characterized as varying capacitance to model hysteresis. A Landau-Khalatnikov subcircuit which portrays this variation is the principal addition to the conventional model to include hysteresis effect. The model parameters of the subcircuit are estimated from the inherent properties of perovskites. Hence, the proposed equivalent circuit model is completely physics based and it links the material property of perovskite to its equivalent circuit model parameters.
Long-term treatment outcomes of pediatric low-grade gliomas treated at a university-based hospital
Authors: Jujui-eam Apisak , Sirachainan Nongnuch , Hongeng Suradej , Hansasuta Ake , Boongird Attaporn , Tritanon Oranan , Dhanachai Mantana , Swangsilpa Thiti , Ruangkanchanasetr Rawee , Worawongsakul Rasin , Puataweepong Putipun 
Published: September 2022

Abstract
Purpose
A multimodality approach is generally considered for pediatric low-grade gliomas (LGG); however, the optimal management remains uncertain. The objective of the study was to evaluate treatment outcomes of pediatric LGG, focusing on long-term survival and factors related to outcomes.
Methods
A retrospective review of 77 pediatric LGG cases treated at Ramathibodi Hospital, Thailand between 2000 and 2018 was performed. The inclusion criteria were all pediatric LGG cases aged ≤ 15 years. Diffuse intrinsic pontine gliomas and spinal cord tumors were excluded.
Results
The median follow-up time was 8.2 years (range, 0.6–19.7). The median age at diagnosis was 6.2 years (interquartile range, 3.6–11.4). Treatments included surgery (71%), chemotherapy (40%), and radiation therapy (14%). The 10-year overall survival (OS) and 10-year progression-free survival were 94% and 59%, respectively, for the entire cohort. The 10-year OS was 100% in three subgroups of patients: pilocytic subtype, WHO grade 1 tumors, and receipt of gross total resection. After multivariable analysis, older age and no surgery had a significant negative impact on OS.
Conclusions
Excellent outcomes can be achieved in pediatric LGG patients using a multidisciplinary approach. Gross total resection is the standard primary treatment. Chemotherapy is the alternative standard treatment in incomplete resection cases, unresectable patients, or patients with progressive disease. Radiation therapy should be reserved as a salvage treatment option because of late complications that usually affect patients’ quality of life.