bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identifying a core symptom set triggering radiological and endoscopic investigations for suspected recurrent esophago-gastric cancer: a modified Delphi consensus process
Authors: Chidambaram Swathikan , Patel Nikhil M , Sounderajah Viknesh , Alfieri Rita , Bonavina Luigi , Cheong Edward , Cockbain Andy , D’Journo Xavier Benoit , Ferri Lorenzo , Griffiths Ewen A , Grimminger Peter , Gronnier Caroline , Gutschow Christian , Hedberg Jakob , Kauppila Joonas H , Lagarde Sjoerd , Low Donald , Nafteux Philippe , Nieuwenhuijzen Grard , Nilsson Magnus , Rosati Riccardo , Schroeder Wolfgang , Smithers B Mark , van Berge Henegouwen Mark I , van Hillegesberg Richard , Watson David I , Vohra Ravinder , Maynard Nick , Markar Sheraz R 
Published: July 2022

Summary
Background: There is currently a lack of evidence-based guidelines regarding surveillance for recurrence after esophageal and gastric (OG) cancer surgical resection, and which symptoms should prompt endoscopic or radiological investigations for recurrence. The aim of this study was to develop a core symptom set using a modified Delphi consensus process that should guide clinicians to carry out investigations to look for suspected recurrent OG cancer in previously asymptomatic patients. Methods: A web-based survey of 42 questions was sent to surgeons performing OG cancer resections at high volume centers. The first section evaluated the structure of follow-up and the second, determinants of follow-up. Two rounds of a modified Delphi consensus process and a further consensus workshop were used to determine symptoms warranting further investigations. Symptoms with a 75% consensus agreement as suggestive of recurrent cancer were included in the core symptom set. Results: 27 surgeons completed the questionnaires. A total of 70.3% of centers reported standardized surveillance protocols, whereas 3.7% of surgeons did not undertake any surveillance in asymptomatic patients after OG cancer resection. In asymptomatic patients, 40.1% and 25.9% of centers performed routine imaging and endoscopy, respectively. The core set that reached consensus, consisted of eight symptoms that warranted further investigations included; dysphagia to solid food, dysphagia to liquids, vomiting, abdominal pain, chest pain, regurgitation of foods, unexpected weight loss and progressive hoarseness of voice. Conclusion: There is global variation in monitoring patients after OG cancer resection. Eight symptoms were identified by the consensus process as important in prompting radiological or endoscopic investigation for suspected recurrent malignancy. Further randomized controlled trials are necessary to link surveillance strategies to survival outcomes and evaluate prognostic value.
California Native Perennials Attract Greater Native Pollinator Abundance and Diversity Than Nonnative, Commercially Available Ornamentals in Southern California
Authors: Nabors Annika , Hung Keng-Lou James , Corkidi Lea , Bethke James A 
Published: July 2022

Abstract
While many factors have been implicated in global pollinator decline, habitat loss is a key driver of wild pollinator decline in both abundance and species richness. An increase in and diversification of pollinator habitat, even in urban settings, can assist in the conservation of pollinator populations. In Southern California, a highly fragmented and urbanized landscape with a rich yet threatened native pollinator fauna, the availability of food resources for native pollinators hinges largely upon the selection of ornamental plants grown in the urban landscape. To examine the pollinator attractiveness of ornamental plants in a Southern California context, we installed an experimental garden with common California native and nonnative ornamental perennials and observed floral visitation and visitor community composition for 3 yr. Our study demonstrates that while native pollinators visited common ornamental perennials native to California at a higher rate than they visited nonnative ornamentals, introduced honey bees showed no significant preference for either native or nonnative species. Native plants also received a greater diversity of visitor taxa, including a richer suite of native bees. Plant species differed dramatically in attractiveness, by as much as a factor of 12, even within the native status group. Our results suggest that including a data-driven selection of both native and non-native ornamental perennials in the urban landscape can diversify the assemblage of native pollinators, provide critical floral resources throughout the year, and reduce the impact of honey bee landscape foraging dominance by providing plants highly attractive to native pollinators and less so to honey bees.
Jura Novit Curia and the European Court of Human Rights
Authors: Möschel Mathias 
Published: July 2022

Abstract
This article provides the first in-depth analysis of the European Court of Human Rights’ treatment of the jura novit curia principle. It explains how and why it has been used more frequently over the past 10 years, provides a classification of the case law and critically analyses the existing legal issues and debates that have emerged from the jurisprudence and doctrine. In particular, the 2018 Grand Chamber judgment Radomilja v. Croatia has brought jura novit curia and its potentially controversial role in the interpretation of the European Convention on Human Rights to light. Overall, this article demonstrates that this seemingly anodyne and previously understudied principle reveals conflicting views regarding the functions and purposes of the European Court of Human Rights’ human rights jurisprudence. I argue that the Strasbourg judges should be careful to use the principle consistently and refrain from overusing it, especially in the later stages of proceedings and in order to reduce its case docket.
Craniofacial structures, occlusal features, and TMD symptoms in juvenile idiopathic arthritis patients: a retrospective study
Authors: Huhtanen Mia , Mikola Katriina , Kiukkonen Anu , Palotie Tuula 
Published: July 2022

Summary

Background
Juvenile idiopathic arthritis (JIA) is a chronic inflammatory disease in which temporomandibular joint (TMJ) arthritis commonly occurs. It may be asymptomatic and could cause problems in the growing joints. Our aim was to evaluate the craniofacial structures, occlusal features and temporomandibular dysfunction (TMD) symptoms of patients with JIA.

Methods
The study consisted of 195 JIA patients treated at the Department of Oral and Maxillofacial Diseases, Helsinki University Hospital (HUH), Finland between 2015 and 2019. We retrospectively screened their medical and dental records and classified them according to age at JIA diagnosis (&lt;7 and ≥7 years).

Results
Most of the patients had Angle Class I occlusion in both sides. Among all the patients, the mean overjet, and overbite were 3.3 mm and 2.4 mm, respectively. There were more open bite patients in the ≥7 years old group than in the &lt;7 years old group (P = 0.010). Of all patients, 47% reported at least one TMD symptom. The TMD symptoms were more common in participants ≥7 years old than those &lt;7 years old (P = 0.005).

Conclusion
Occlusal features and the incidence of malocclusions seem to have similar tendency among the JIA patients with systematic visits in rheumatologist and orthodontist as in the healthy population, except for open bite that is more common with JIA patients. While treating JIA patients, a well-functioning collaboration between paediatric rheumatologists and orthodontists is essential, as well as a clear screening protocol to detect potentially asymptomatic TMJ arthritis. Particular attention should be paid to children with JIA under school age.
Sex-specific associations between potassium intake, blood pressure, and cardiovascular outcomes: the EPIC-Norfolk study
Authors: Wouda Rosa D , Boekholdt S Matthijs , Khaw Kay Tee , Wareham Nicholas J , de Borst Martin H , Hoorn Ewout J , Rotmans Joris I , Vogt Liffert 
Published: July 2022

AbstractAimsA potassium replete diet is associated with lower blood pressure (BP) and lower risk of cardiovascular disease (CVD). Whether these associations differ between men and women and whether they depend on daily sodium intake is unknown.Methods and resultsAn analysis was performed in 11 267 men and 13 696 women from the EPIC-Norfolk cohort. Twenty-four hour excretion of sodium and potassium, reflecting intake, was estimated from sodium and potassium concentration in spot urine samples using the Kawasaki formula. Linear and Cox regression were used to explore the association between potassium intake, systolic BP (SBP), and CVD events (defined as hospitalization or death due to CVD). After adjustment for confounders, interaction by sex was found for the association between potassium intake and SBP (P &lt; 0.001). In women, but not in men, the inverse slope between potassium intake and SBP was steeper in those within the highest tertile of sodium intake compared with those within the lowest tertile of sodium intake (P &lt; 0.001 for interaction by sodium intake). Both in men and women, higher potassium intake was associated with a lower risk of CVD events, but the hazard ratio (HR) associated with higher potassium intake was lower in women than in men [highest vs. lowest potassium intake tertile: men: HR 0.93, 95% confidence interval (CI) 0.87–1.00; women: HR 0.89, 95% CI 0.83–0.95, P = 0.033 for interaction by sex].ConclusionThe association between potassium intake, SBP, and CVD events is sex specific. The data suggest that women with a high sodium intake in particular benefit most from a higher potassium intake with regard to SBP.
A randomized control trial of a Canadian-based school food program on the home food environment
Authors: Reagan Rebecca , Woodruff Sarah J , Seabrook Jamie A , Gilliland Jason 
Published: July 2022

Abstract
Research provides evidence of take-home effects in school-based nutrition interventions, citing children as important influencers of family nutrition, acting as agents of change in the household and potentially influencing family food consumption. Therefore, the purpose of this randomized control trial was to examine whether implementation of a centrally procured school food program would produce changes in children’s home food environment, including fruit and/or vegetable availability and parental modelling of fruit and/or vegetable consumption. A secondary objective was to investigate whether children’s fruit and/or vegetable intake predicted their parent’s fruit and/or vegetable intake. A total of 60 schools participated in the evaluation, including 2443 students (and their parents) in grades 5–8. Findings indicated that the intervention did not produce take-home effects on children’s home availability of fruit (p = 0.52) and vegetables (p = 0.67) or parental modelling of fruit (p = 0.26) and vegetable consumption (p = 0.78), which may be related to the fact that only food provisions were given. However, children’s fruit and vegetable consumption predicted parents’ fruit and vegetable consumption (p &lt; 0.001), thereby indicating that children may possess the capacity to influence home nutrition. Future school-based nutrition interventions are recommended to be multi-component (e.g. experiential learning, parent involvement) and that encourage nutrition leadership opportunities for children in the home context.
Periareolar endoscopic minimally invasive cardiac surgery: postoperative scar assessment analysis
Authors: Van Praet Karel M , Kofler Markus , Akansel Serdar , Montagner Matteo , Meyer Alexander , Sündermann Simon H , Falk Volkmar , Kempfert Jörg 
Published: July 2022

Abstract

OBJECTIVES
The standard approach for minimally invasive cardiac surgery (MICS) for repair of the atrioventricular valves is a right lateral minithoracotomy. In this study, we report our experience with a periareolar endoscopic approach, which aims at an optimal cosmetic outcome while preserving optimal clinical outcomes.

METHODS
All patients underwent periareolar endoscopic MICS using high-definition three-dimensional endoscopic visualization without additional rib-spreading. Patients presented with degenerative and/or functional mitral regurgitation. Patients undergoing concomitant tricuspid valve surgery, cryo-ablation, patent foramen ovale closure, left atrial appendage occlusion and/or left atrial myxoma extirpation were included. This descriptive article analysed the aesthetic and functional outcome of the periareolar scar using 5 most common and clinimetrically sound scar assessment scales. For statistical analysis of the scar assessment grading scales, box and whisker plots were calculated depicting median, interquartile range and high and low range data points.

RESULTS
Median scar assessment scale scores for n = 100 male patients (response rate 100/109; 91.7%) were 2 [1, 4], 7.5 [6, 9], 11 [8, 14], 3 [2, 3] and 10 [9, 11] for the Vancouver scar scale, Manchester scar scale, patient scar assessment scale, Stony brook scar evaluation scale and Dermatology Quality of Life Index scale, respectively. Ninety-seven patients received mitral valve repair, 7 mitral valve replacement, whereas 5 had left atrial myxoma extirpation. Concomitant tricuspid annuloplasty, cryo-ablation, left atrial appendage occlusion and patent foramen ovale closure surgery were performed in 12, 29, 5 and 8 patients, respectively. Median procedure, cardiopulmonary bypass and cross-clamp times were 169.5 [154.3, 189.3], 111.5 [97, 127], and 68.5 [58.8, 81] min, respectively.

CONCLUSIONS
Periareolar endoscopic MICS is safe and cosmetically appealing. It is feasible and allows for complex mitral valve repair, mitral valve replacement and concomitant surgery. Data from 5 scar assessment scales suggest that this technique delivers patient-satisfying results regarding functional and cosmetic outcomes.
Bongartz Completion via c-Vectors
Authors: Cao Peigen , Gyoda Yasuaki , Yurikusa Toshiya 
Published: July 2022

Abstract
In the present paper, we first give a characterization for Bongartz completion in $\tau $-tilting theory via $c$-vectors. Motivated by this characterization, we give the definition of Bongartz completion in cluster algebras using $c$-vectors. Then we prove the existence and uniqueness of Bongartz completion in cluster algebras. We also prove that Bongartz completion admits certain commutativity. We give two applications for Bongartz completion in cluster algebras. As the first application, we prove the full subquiver of the exchange quiver (or known as oriented exchange graph) of a cluster algebra $\mathcal A$ whose vertices consist of the seeds of $\mathcal A$ containing particular cluster variables is isomorphic to the exchange quiver of another cluster algebra. As the second application, we prove that in a $Y$-pattern over a universal semifield, each $Y$-seed (up to a $Y$-seed equivalence) is uniquely determined by the negative $y$-variables in this $Y$-seed.
Molecular ecology and risk factors for third-generation cephalosporin-resistant Escherichia coli carriage by dogs living in urban and nearby rural settings
Authors: Sealey Jordan E , Hammond Ashley , Mounsey Oliver , Gould Virginia C , Reyher Kristen K , Avison Matthew B 
Published: July 2022

Abstract

Objectives
To compare faecal third-generation cephalosporin-resistant (3GC-R) Escherichia coli isolates from dogs living in a city and in a rural area ∼30 km away; to compare isolates from dogs, cattle and humans in these regions; and to determine risk factors associated with 3GC-R E. coli carriage in these two cohorts of dogs.

Methods
Six hundred dogs were included, with faecal samples processed to recover 3GC-R E. coli using 2 mg/L cefotaxime. WGS was by Illumina and risk factor analyses were by multivariable linear regression using the results of an owner-completed survey.

Results
3GC-R E. coli were excreted by 20/303 rural and 31/297 urban dogs. The dominant canine 3GC-R ST was ST963 (blaCMY-2), which also accounted for 25% of CMY-2-producing E. coli in humans. Phylogenetic overlap between cattle and rural dog CTX-M-14-producing E. coli ST117 was observed as well as acquisition of pMOO-32-positive E. coli ST10 by a rural dog, a plasmid common on cattle farms in the area. Feeding raw meat was associated with carrying 3GC-R E. coli in rural dogs, but not in urban dogs, where swimming in rivers was a weak risk factor.

Conclusions
Given clear zoonotic potential for resistant canine E. coli, our work suggests interventions that may reduce this threat. In rural dogs, carriage of 3GC-R E. coli, particularly CTX-M producers, was phylogenetically associated with interaction with local cattle and epidemiologically associated with feeding raw meat. In urban dogs, sources of 3GC-R E. coli appear to be more varied and include environments such as rivers.
Success rate of acquiring informed consent and barriers to participation in a randomized controlled trial of laparoscopic versus open surgery for non-curative stage IV colon cancer in Japan (JCOG1107)
Authors: Akagi Tomonori , Suzuki Kosuke , Kono Yohei , Ninomiya Shigeo , Shibata Tomotaka , Ueda Yoshitake , Shiroshita Hidefumi , Etoh Tsuyoshi , Shiomi Akio , Ito Masaaki , Watanabe Jun , Murata Kohei , Hirano Yasumitsu , Shimomura Manabu , Tsukamoto Shunsuke , Kanemitsu Yukihide , Inomata Masafumi ,   the Colorectal Cancer Study Group of Japan Clinical Oncology Group
Published: July 2022

Abstract

Background
Successful achievement of randomized controlled trials (RCTs) is dependent on the acquisition of informed consent (IC) from patients. The aim of this study was to prospectively calculate the proportion of participation in a surgical RCT and to identify the reasons for failed acquisition of IC.

Methods
A 50-insitution RCT was conducted to evaluate oncological outcomes of open and laparoscopic surgery for stage IV colon cancer (JCOG1107: UMIN-CTR 000000105). The success rate of obtaining IC was evaluated in eight periods between January 2013 and January 2021. In addition, reasons for failed acquisition of IC were identified from questionnaires.

Results
In total, 391 patients were informed of their eligibility for the trial, and 168 (42%) were randomly assigned to either the laparoscopic surgery group (n = 84) or open surgery group (n = 84). The success rate of IC acquisition ranged from 33 to 58% in three periods. The most common reasons for failed IC acquisition were the patients’ preference for one approach of surgery based on recommendations from referring doctors and family members, and anxiety/unhappiness about randomization.

Conclusions
The success rate of acquiring IC from patients for an RCT of laparoscopic versus open surgery for stage IV colon cancer was lower than the expected rate planned in the protocol. To obtain the planned rate, investigators should make efforts to inform patients and their families about the medical contributions a surgical RCT can make and recognize that the period in equipoise may be limited.
Distinct Brain Proteomic Signatures in Cerebral Small Vessel Disease Rat Models of Hypertension and Cerebral Amyloid Angiopathy
Authors: Schrader Joseph M , Stanisavljevic Aleksandra , Xu Feng , Van Nostrand William E 
Published: July 2022

Abstract
Cerebral small vessel diseases (CSVDs) are prominent contributors to vascular cognitive impairment and dementia and can arise from a range of etiologies. Cerebral amyloid angiopathy (CAA) and hypertension (HTN), both prevalent in the elderly population, lead to cerebral microhemorrhages, macrohemorrhages, and white matter damage. However, their respective underlying mechanisms and molecular events are poorly understood. Here, we show that the transgenic rat model of CAA type 1 (rTg-DI) exhibits perivascular inflammation that is lacking in the spontaneously hypertensive stroke-prone (SHR-SP) rat model of HTN. Alternatively, SHR-SP rats display notable dilation of arteriolar perivascular spaces. Comparative proteomics analysis revealed few shared altered proteins, with key proteins such as ANXA3, H2A, and HTRA1 unique to rTg-DI rats, and Nt5e, Flot-1 and Flot-2 unique to SHR-SP rats. Immunolabeling confirmed that upregulation of ANXA3, HTRA1, and neutrophil extracellular trap proteins were distinctly associated with rTg-DI rats. Pathway analysis predicted activation of TGF-β1 and TNFα in rTg-DI rat brain, while insulin signaling was reduced in the SHR-SP rat brain. Thus, we report divergent protein signatures associated with distinct cerebral vessel pathologies in the SHR-SP and rTg-DI rat models and provide new mechanistic insight into these different forms of CSVD.
The United Nations Security Council and Human Rights: Who Ends Up in the Spotlight?
Authors: Allen Susan Hannah , Bell Sam R 
Published: July 2022

Abstract
At the end of the Cold War, the United Nations Security Council broadened its view on what constitutes a “threat to international peace and security.” With the rise of the concept of human security and increased focus on human rights, the Council has been more willing to act in response to domestic political issues such as human rights abuses. Despite an increased commitment to human security, the Council's attention on these issues has been uneven. What determines whose rights capture the Council's attention? What role do efforts by NGOs to “name and shame” play in the setting of the Council's agenda? We find that human rights abuses lead to countries being placed on the Council's agenda, but human rights organization naming and shaming results in more action by the Council—in terms of both meetings held and resolutions passed.
Shared Positions on Divisive Beliefs Explain Interorganizational Collaboration: Evidence from Climate Change Policy Subsystems in 11 Countries
Authors: Karimo Aasa , Wagner Paul M , Delicado Ana , Goodman James , Gronow Antti , Lahsen Myanna , Lin Tze-Luen , Ocelík Petr , Schneider Volker , Satoh Keiichi , Schmidt Luisa , Yun Sun-Jin , Ylä-Anttila Tuomas 
Published: July 2022

Abstract
Collaboration between public administration organizations and various stakeholders is often prescribed as a potential solution to the current complex problems of governance, such as climate change. According to the Advocacy Coalition Framework, shared beliefs are one of the most important drivers of collaboration. However, studies investigating the role of beliefs in collaboration show mixed results. Some argue that similarity of general normative and empirical policy beliefs elicits collaboration, while others focus on beliefs concerning policy instruments. Proposing a new divisive beliefs hypothesis, we suggest that agreeing on those beliefs over which there is substantial disagreement in the policy subsystem is what matters for collaboration. Testing our hypotheses using policy network analysis and data on climate policy subsystems in 11 countries (Australia, Brazil, the Czech Republic, Germany, Finland, Ireland, Japan, Korea, Portugal, Sweden, and Taiwan), we find belief similarity to be a stronger predictor of collaboration when the focus is divisive beliefs rather than normative and empirical policy beliefs or beliefs concerning policy instruments. This knowledge can be useful for managing collaborative governance networks because it helps to identify potential competing coalitions and to broker compromises between them.