bluuebunny/crossref_metadata_2025_split huggingface dataset:
Native T1 mapping for the diagnosis of cardiac amyloidosis in patients with left ventricular hypertrophy
Authors: Lavall Daniel , Vosshage Nicola H. , Geßner Romy , Stöbe Stephan , Ebel Sebastian , Denecke Timm , Hagendorff Andreas , Laufs Ulrich 
Published: March 2022

Abstract
Background
Cardiac magnetic resonance (CMR) with parametric mapping can improve the characterization of myocardial tissue. We studied the diagnostic value of native T1 mapping to detect cardiac amyloidosis in patients with left ventricular (LV) hypertrophy.

Methods
One hundred twenty-five patients with increased LV wall thickness (≥ 12 mm end-diastole) who received clinical CMR in a 3 T scanner between 2017 and 2020 were included. 31 subjects without structural heart disease served as controls. Native T1 was measured as global mean value from 3 LV short axis slices. The study was registered at German clinical trial registry (DRKS00022048).

Results
Mean age of the patients was 66 ± 14 years, 83% were males. CA was present in 24 patients, 21 patients had hypertrophic cardiomyopathy (HCM), 80 patients suffered from hypertensive heart disease (HHD). Native T1 times were higher in patients with CA (1409 ± 59 ms, p < 0.0001) compared to healthy controls (1225 ± 21 ms), HCM (1266 ± 44 ms) and HHD (1257 ± 41 ms). HCM and HHD patients did not differ in their native T1 times but were increased compared to control (p < 0.01). ROC analysis of native T1 demonstrated an area under the curve for the detection of CA vs. HCM and HHD of 0.9938 (p < 0.0001), which was higher than that of extracellular volume (0.9876) or quantitative late gadolinium enhancement (0.9406; both p < 0.0001). The optimal cut-off value of native T1 to diagnose CA was 1341 ms (sensitivity 100%, specificity 97%).

Conclusion
Non-contrast CMR imaging with native T1 mapping provides high diagnostic accuracy to diagnose cardiac amyloidosis in patients with left ventricular hypertrophy.
Alkaline nucleoplasm facilitates contractile gene expression in the mammalian heart
Authors: Hulikova Alzbeta , Park Kyung Chan , Loonat Aminah A. , Gunadasa-Rohling Mala , Curtis M. Kate , Chung Yu Jin , Wilson Abigail , Carr Carolyn A. , Trafford Andrew W. , Fournier Marjorie , Moshnikova Anna , Andreev Oleg A. , Reshetnyak Yana K. , Riley Paul R. , Smart Nicola , Milne Thomas A. , Crump Nicholas T. , Swietach Pawel 
Published: March 2022

AbstractCardiac contractile strength is recognised as being highly pH-sensitive, but less is known about the influence of pH on cardiac gene expression, which may become relevant in response to changes in myocardial metabolism or vascularization during development or disease. We sought evidence for pH-responsive cardiac genes, and a physiological context for this form of transcriptional regulation. pHLIP, a peptide-based reporter of acidity, revealed a non-uniform pH landscape in early-postnatal myocardium, dissipating in later life. pH-responsive differentially expressed genes (pH-DEGs) were identified by transcriptomics of neonatal cardiomyocytes cultured over a range of pH. Enrichment analysis indicated “striated muscle contraction” as a pH-responsive biological process. Label-free proteomics verified fifty-four pH-responsive gene-products, including contractile elements and the adaptor protein CRIP2. Using transcriptional assays, acidity was found to reduce p300/CBP acetylase activity and, its a functional readout, inhibit myocardin, a co-activator of cardiac gene expression. In cultured myocytes, acid-inhibition of p300/CBP reduced H3K27 acetylation, as demonstrated by chromatin immunoprecipitation. H3K27ac levels were more strongly reduced at promoters of acid-downregulated DEGs, implicating an epigenetic mechanism of pH-sensitive gene expression. By tandem cytoplasmic/nuclear pH imaging, the cardiac nucleus was found to exercise a degree of control over its pH through Na+/H+ exchangers at the nuclear envelope. Thus, we describe how extracellular pH signals gain access to the nucleus and regulate the expression of a subset of cardiac genes, notably those coding for contractile proteins and CRIP2. Acting as a proxy of a well-perfused myocardium, alkaline conditions are permissive for expressing genes related to the contractile apparatus.
A novel male Japanese quail structural connectivity atlas using ultra-high field diffusion MRI at 11.7 T
Authors: Yebga Hot Raïssa , Siwiaszczyk Marine , Love Scott A. , Andersson Frédéric , Calandreau Ludovic , Poupon Fabrice , Beaujoin Justine , Herlin Bastien , Boumezbeur Fawzi , Mulot Baptiste , Chaillou Elodie , Uszynski Ivy , Poupon Cyril 
Published: March 2022

AbstractThe structural connectivity of animal brains can be revealed using post-mortem diffusion-weighted magnetic resonance imaging (MRI). Despite the existence of several structural atlases of avian brains, few of them address the bird’s structural connectivity. In this study, a novel atlas of the structural connectivity is proposed for the male Japanese quail (Coturnix japonica), aiming at investigating two lines divergent on their emotionality trait: the short tonic immobility (STI) and the long tonic immobility (LTI) lines. The STI line presents a low emotionality trait, while the LTI line expresses a high emotionality trait. 21 male Japanese quail brains from both lines were scanned post-mortem for this study, using a preclinical Bruker 11.7 T MRI scanner. Diffusion-weighted MRI was performed using a 3D segmented echo planar imaging (EPI) pulsed gradient spin-echo (PGSE) sequence with a 200 $$\upmu$$μm isotropic resolution, 75 diffusion-encoding directions and a b-value fixed at 4500 s/mm2. Anatomical MRI was likewise performed using a 2D anatomical T2-weighted spin-echo (SE) sequence with a 150 $$\upmu$$μm isotropic resolution. This very first anatomical connectivity atlas of the male Japanese quail reveals 34 labeled fiber tracts and the existence of structural differences between the connectivity patterns characterizing the two lines. Thus, the link between the male Japanese quail’s connectivity and its underlying anatomical structures has reached a better understanding.
Measuring and modelling microclimatic air temperature in a historically degraded tropical forest
Authors: Marsh Christopher D. , Hill Ross A. , Nowak Matthew G. , Hankinson Emma , Abdullah Abdullah , Gillingham Phillipa , Korstjens Amanda H. 
Published: March 2022

AbstractClimate change is predicted to cause widespread disruptions to global biodiversity. Most climate models are at the macroscale, operating at a ~ 1 km resolution and predicting future temperatures at 1.5–2 m above ground level, making them unable to predict microclimates at the scale that many organisms experience temperature. We studied the effects of forest structure and vertical position on microclimatic air temperature within forest canopy in a historically degraded tropical forest in Sikundur, Northern Sumatra, Indonesia. We collected temperature measurements in fifteen plots over 20 months, alongside vegetation structure data from the same fifteen 25 × 25 m plots. We also performed airborne surveys using an unmanned aerial vehicle (UAV) to record canopy structure remotely, both over the plot locations and a wider area. We hypothesised that old-growth forest structure would moderate microclimatic air temperature. Our data showed that Sikundur is a thermally dynamic environment, with simultaneously recorded temperatures at different locations within the canopy varying by up to ~ 15 °C. Our models (R2 = 0.90 to 0.95) showed that temperature differences between data loggers at different sites were largely determined by variation in recording height and the amount of solar radiation reaching the topmost part of the canopy, although strong interactions between these abiotic factors and canopy structure shaped microclimate air temperature variation. The impacts of forest degradation have smaller relative influence on models of microclimatic air temperature than abiotic factors, but the loss of canopy density increases temperature. This may render areas of degraded tropical forests unsuitable for some forest-dwelling species with the advent of future climate change.
Fear of prognosis? How anxiety, coping, and expected burden impact the decision to have cytogenetic assessment in uveal melanoma patients
Authors: Gollrad Johannes , Korpusik Nevenka , Rabsahl Christopher , Boehmer Dirk , Besserer Angela , Grittner Ulrike , Boeker Alexander , Keilholz Ulrich , Joussen Antonia , Budach Volker , Goerling Ute 
Published: March 2022

Abstract
Background
Cytogenetic testing (CGT) in uveal melanoma patients reveals prognostic information about the individual risk of developing distant metastasis with dismal prognosis. There is currently no medical intervention strategy with proven effect on the prognosis, rendering the result of the cytogenetic testing purely informative. We explored patients’ socio-demographic backgrounds, psychological preconditions, coping strategies, external influences, and concerns about “knowing their fate” to study their possible interactions with decision-making for CGT.

Methods
Uveal melanoma patients were asked to complete questionnaires on their interest in undergoing CGT for prognostication and the factors influencing their decision. Data were collected on socio-demographics, baseline anxiety (GAD-7), depression (PHQ-9), coping strategies (Brief COPE), and assumed future concerns regarding the CGT result. Data were analyzed by using multiple ordinal logistic regression and exploring estimated marginal effects.

Results
Questionnaires were returned by 121 of 131 (92.4%) patients. Fifty-two patients (43%) had no interest in CGT, 34 (28.1%) were undecided, and 35 (28.9%) were interested. We observed no significant differences regarding age, sex, partnership, education, occupation, baseline anxiety, or depression. Decision-making favoring CGT was influenced by the treating physicians, internet resources, and level of baseline anxiety. Patients were likely to reject CGT when they worried that “knowing the result will have an unintended influence” on their life.

Conclusion
Decision-making about CGT for prognostication in uveal melanoma is burdensome to many patients and in general not guided by medical advice regarding further treatment and screening procedures. The psychological impact of the decision is therefore unique and requires careful support by psycho-oncologists considering the patient’s fears and expectations.
Impact of myocardial injury on regional left ventricular function in the course of acute myocarditis with preserved ejection fraction: insights from segmental feature tracking strain analysis using cine cardiac MRI
Authors: Weber L. , Sokolska J. M. , Nadarevic T. , Karolyi M. , Baessler B. , Fischer X. , Sokolski M. , von Spiczak J. , Polacin M. , Matziris I. , Alkadhi H. , Robert M. 
Published: March 2022

AbstractThe aim of this study was to provide insights into myocardial adaptation over time in myocyte injury caused by acute myocarditis with preserved ejection fraction. The effect of myocardial injury, as defined by the presence of late gadolinium enhancement (LGE), on the change of left ventricular (LV) segmental strain parameters was evaluated in a longitudinal analysis. Patients with a first episode of acute myocarditis were enrolled retrospectively. Peak radial (PRS), longitudinal (PLS) and circumferential (PCS) LV segmental strain values at baseline and at follow-up were computed using feature tracking cine cardiac magnetic resonance imaging. The change of segmental strain values in LGE positive (LGE+) and LGE negative (LGE−) segments was compared over a course of 89 ± 20 days. In 24 patients, 100 LGE+ segments and 284 LGE− segments were analysed. Between LGE+ and LGE− segments, significant differences were found for the change of segmental PCS (p < 0.001) and segmental PRS (p = 0.006). LGE + segments showed an increase in contractility, indicating recovery, and LGE− segments showed a decrease in contractility, indicating normalisation after a hypercontractile state or impairment of an initially normal contracting segment. No significant difference between LGE+ and LGE− segments was found for the change in segmental PLS. In the course of acute myocarditis with preserved ejection fraction, regional myocardial function adapts inversely in segments with and without LGE. As these effects seem to counterbalance each other, global functional parameters might be of limited use in monitoring functional recovery of these patients.
Bicomponent regenerated cellulose fibres: retaining the colour from waste cotton textiles
Authors: Rosson Lucas , Byrne Nolene 
Published: March 2022

AbstractBicomponent regenerated cellulose fibres (bRCF) have been created in a core–shell configuration from waste textiles. Textile dyeing and colouration is known to be a major contributor to the environmental impact of producing textiles and this needs to be addressed for textiles to become more sustainable. Coloration of the bRCF here was achieved by utilizing coloured textile waste in the shell component whilst using white cotton waste in the core. The shell and core extrusion speed and thus shell and core diameter were varied and optimised for colour strength. The optimised bRCF was made up of 49.6% dyed material yet was able to achieve the same colour strength as the single component regenerated cellulose fibre (RCF). The potential benefit of this approach is the reduced amount of coloured material required to colour these recycled fibres without any sacrifice in colour intensity. The mechanical properties of the bRCF were similar to the single component RCF with tensile strengths of 115–116 MPa and maximum elongations of 15.2–17.5%. The morphology of the bRCF was similar to single component regenerated cellulose fibres, while optical micrographs showed the discrete coloured core–shell structure of the bRCF. This manuscript details the fibre properties, dye savings and spinning approach.
A two-step carbon pricing scheme enabling a net-zero and net-negative CO$$_2$$-emissions world
Authors: Becattini Viola , Gabrielli Paolo , Frattini Linda , Weisbach David , Mazzotti Marco 
Published: March 2022

AbstractThis contribution introduces a novel carbon pricing system and illustrates its benefits. The system is based on two related but distinct ideas. First, we group the global pools of carbon into three aggregate pools, and we tax or credit human-caused carbon fluxes across the boundaries of the pools. Second, we base the tax or credit solely on physical movements of carbon between pools; hence, the system uses a physical baseline instead of a behavioral baseline based on the hypothetical emissions levels that would have arisen absent the carbon price. The proposed system goes beyond the limitations of current carbon pricing schemes for a number of reasons: it is designed to capture all positive and negative emissions based purely on their climate impact, allowing a broader scope and more appropriate incentives than current systems; it avoids creating bad incentives, particularly those caused by additionality requirements found in carbon offset systems; it captures the complexity of carbon movements through human and natural systems; it reduces measurement errors; and it provides transparent and easily observed price signals. Though this manuscript is conceptual in nature and refrains from discussing the technicalities related to the implementation of the proposed carbon pricing system, we trust that it may contribute to the development of policies enabling a net-zero and net-negative CO$$_{2}$$

2

-emissions world.
A Dynamic Baseline Calibration Procedure for CGE models
Authors: Ziesmer Johannes , Jin Ding , Thube Sneha D , Henning Christian 
Published: March 2022

AbstractBaseline assumptions play a crucial role in conducting consistent quantitative policy assessments for dynamic Computable General Equilibrium (CGE) models. Two essential factors that influence the determination of the baselines are the data sources of projections and the applied calibration methods. We propose a general, Bayesian approach that can be employed to build a baseline for any recursive-dynamic CGE model. We use metamodeling techniques to transform the calibration problem into a tractable optimization problem while simultaneously reducing the computational costs. This transformation allows us to derive the exogenous model parameters that are needed to match the projections. We demonstrate how to apply the approach using a simple CGE and supply the full code. Additionally, we apply our method to a multi-region, multi-sector model and show that calibrated parameters matter as policy implications derived from simulations differ significantly between them.
Accelerating the Pool-Adjacent-Violators Algorithm for Isotonic Distributional Regression
Authors: Henzi Alexander , Mösching Alexandre , Dümbgen Lutz 
Published: March 2022

AbstractIn the context of estimating stochastically ordered distribution functions, the pool-adjacent-violators algorithm (PAVA) can be modified such that the computation times are reduced substantially. This is achieved by studying the dependence of antitonic weighted least squares fits on the response vector to be approximated.
Neurocognitive functioning and health-related quality of life of children after pediatric intensive care admission: a systematic review
Authors: Hordijk José A. , Verbruggen Sascha C. , Buysse Corinne M. , Utens Elisabeth M. , Joosten Koen F. , Dulfer Karolijn 
Published: March 2022

AbstractObjectiveThis study systematically reviewed recent findings on neurocognitive functioning and health-related quality of life (HRQoL) of children after pediatric intensive care unit admission (PICU).Data sourcesElectronic databases searched included Embase, Medline Ovid, Web of Science, Cochrane CENTRAL, and Google Scholar. The search was limited to studies published in the last five years (2015–2019).Study selectionOriginal studies assessing neurocognitive functioning or HRQoL in children who were previously admitted to the PICU were included in this systematic review.Data extractionOf the 3649 identified studies, 299 met the inclusion criteria based on title abstract screening. After full-text screening, 75 articles were included in the qualitative data reviewing: 38 on neurocognitive functioning, 33 on HRQoL, and 4 on both outcomes.Data synthesisStudies examining neurocognitive functioning found overall worse scores for general intellectual functioning, attention, processing speed, memory, and executive functioning. Studies investigating HRQoL found overall worse scores for both physical and psychosocial HRQoL. On the short term (≤ 12 months), most studies reported HRQoL impairments, whereas in some long-term studies HRQoL normalized. The effectiveness of the few intervention studies during and after PICU admission on long-term outcomes varied.ConclusionsPICU survivors have lower scores for neurocognitive functioning and HRQoL than children from the general population. A structured follow-up program after a PICU admission is needed to identify those children and parents who are at risk. However, more research is needed into testing interventions in randomized controlled trials aiming on preventing or improving impairments in critically ill children during and after PICU admission.
The Sexual and Emotional Life Experiences Reported by Brazilian Men with Head and Neck Cancer at a Public University Hospital: A Qualitative Study
Authors: Sant’Ana Ricardo Souza Evangelista , Zerbinati João Paulo , de Faria Maria Eufrasia , Lima Carmen Silvia Passos , Maheu Christine , Turato Egberto Ribeiro 
Published: March 2022

AbstractThis study explored the sexual and emotional experiences of male patients with head and neck cancer. This study utilized a clinical-qualitative method. Twelve patients with head and neck cancer were recruited to participate in the research through in-depth semi-directed interviews with open-ended questions recorded. Data was collected at the radiotherapy of a Brazilian hospital. All patients demonstrated negative impacts on the dynamics of affective and sexual relationships caused by a serious disease. Data revealed that impacts mainly affect “The felt/lived body”, and “The affective-sexual body”. Requiring, then, an “Elaboration of the grief of the bodily and sexual changes”. Considering, evaluating and proposing care for a sexual and emotional aspects of patients with head and neck cancer is essential for the creation and implementation of comprehensive health measures, especially in terms of quality of life for patients.
Expectancies and Motives as Predictors of Risky Alcohol Consumption in College Women
Authors: Cortés-Tomás María-Teresa , Giménez-Costa José-Antonio , Motos-Sellés Patricia , Sancerni-Beitia María-Dolores 
Published: March 2022

AbstractDespite the consequences of alcohol use, it continues showing a high incidence among college students. Besides, the increasing presence of women in risk alcohol patterns calls for a gender-sensitive approach to design specific actions. Some variables have been analyzed as underlying alcohol consumption (expectations and motives). This paper assesses the type and influence of both variables on female university alcohol consumers at different levels of risk. Five hundred four college women were assessed using the Spanish adaptations of the Expectancy Questionnaire, the Drinking Motives Questionnaire-Revised, and the AUDIT. We determine the unique contributions of expectancies, motives, and the presence of binge drinking (BD) to the pattern of risky drinking. The percentage of variance explained by risky drinking is 37.7%. Negative expectancies (20.4%) are the most explanatory variables, followed by enhancement motives (10.4%). Interventions with university women should focus on their negative expectancies, in addition to addressing for improvement, coping with depression, and conformity motives.
NMR Metabolome-Based Classification of Cymbopogon Species: a Prospect for Phyto-equivalency of its Different Accessions Using Chemometric Tools
Authors: Otify Asmaa M. , Serag Ahmed , Porzel Andrea , Wessjohann Ludger A. , Farag Mohamed A. 
Published: March 2022

Abstract
Cymbopogon species are widely distributed worldwide and known for their high essential oil content with potential commercial and medicinal benefits justifying for their inclusion in food and cosmetics. Most species received scant characterization regarding their full complement of bioactive constituents necessary to explain their medicinal activities. In this study, the metabolite profiles of 5 Cymbopogon species, C. citratus, C. flexuosus, C. procerus, C. martini, and C. nardus, were characterized via NMR-based metabolomics. The results of 13 shoot accessions revealed the identification and quantification of 23 primary and secondary metabolites belonging to various compound classes. Multivariate analyses were used for species classification, though found not successful in discrimination based on geographical origin. Nevertheless, C. citratus was found particularly enriched in neral, geranial, (E)-aconitic acid, isoorientin, and caffeic acid as the major characterizing metabolites compared to other species, while an unknown apigenin derivative appeared to discriminate C. martini. The high essential oil and phenolic content in C. citratus emphasizes its strong antioxidant activity, whereas (E)-aconitic acid accounts for its traditional use as insecticide. This study affords the first insight into metabolite compositional differences among Cymbopogon species. Moreover, antimicrobial, insecticidal, antidiabetic, and antioxidant compounds were identified that can be utilized as biomarkers for species authentication.