bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association between Post-acute Sequelae of SARS-CoV-2 and Physical Inactivity: A Cohort Study of 614 COVID-19 survivors
Authors: Gil Saulo , Gualano Bruno , Araújo Adriana Ladeira , Júnior Gersiel Nascimento Oliveira , Damiano Rodolfo Furlan , Pinna Fabio , Imamura Marta , Rocha Vanderson , Kallas Esper , Batistella Linamara Rizzo , Forlenza Orestes V. , Carvalho Carlos R.R. , Busatto Geraldo Filho , Roschel Hamilton 
Published: May 2022

Abstract
The aim of this study was to determine whether Post-acute Sequelae of SARS-CoV-2 Infection (PASC) are associated with physical inactivity in COVID-19 survivors. This is a cohort study of COVID-19 survivors discharged from a tertiary hospital in Sao Paulo, Brazil. Patients admitted as inpatients due to laboratory-confirmed COVID-19 between March and August 2020 were consecutively invited for a follow-up in-person visit 6 to 11 months after hospitalization. Ten symptoms of PASC were assessed using standardized scales. Physical activity was assessed by questionnaire and participants were classified according to WHO Guidelines. 614 patients were analyzed (age: 56±13 years; 53% male). Frequency of physical inactivity in patients exhibiting none, at least 1, 1 to 4, and 5 or more symptoms of PASC was 51%, 62%, 58%, and 71%, respectively. Adjusted models showed that patients with one or more persistent PASC symptoms have greater odds of being physically inactive than those without any persistent symptoms (OR: 1.56[95%CI: 1.03 to 2.37], P=0.034). Dyspnea (OR: 2.22[1.50 to 3.33]), fatigue (OR: 1.96[0.43 to 0.95]), insomnia (OR: 1.59[1.10 to 2.31]), post-traumatic stress (OR: 1.53[1.06 to 2.23]), and severe muscle/joint pain (OR: 1.49[95%CI: 1.05 to 2.00]) were associated with greater odds of being physically inactive (all P<0.05). This study suggests that PASC is associated with physical inactivity, which itself may be considered as a persistent symptom among COVID-19 survivors. This may help in the early identification of patients who could benefit from interventions tailored to combat inactivity, with potential beneficial impacts on overall morbidity/mortality and health systems worldwide.
Light-matter-interaction beyond Born-Oppenheimer approximation mediated by stimulated phonon polaritons
Authors: Lu Yao , Wu Qiang , Xiong Hao , Zhou Xu , Li Zhixuan , Qi Jiwei , Xu Xitan , Ma Ruobin , Fan Jiang , Chen Zhigang , Xu Jingjun 
Published: May 2022

Abstract
For decades, the light-matter interaction (LMI) mechanism based on Born-Oppenheimer (BO) approximation has dominated the fields of photonics, materials, and condensed-matter physics. However, in polar crystals, the BO approximation is not applicable when stimulated phonon polaritons (SPhPs) are excited. Unlike the studies on topological physics and physical chemistry that beyond BO approximation, here we unravel an SPhP-mediated LMI (SPhP-LMI) mechanism in polar crystals, which is radically different from the traditional LMI interpreted by BO approximation. In the regime of SPhP-LMI, two exemplary experiments were conducted at different wavelengths: Q-factor increase of a lithium niobate (LiNbO3) terahertz microcavity, and a five orders-of-magnitude enhancement of second-harmonic generation of infrared laser pulses in an LiNbO3 slab. Our study brings about a new fundamental understanding of the LMI mechanism and shows great potential in the fields of optics/photonics and condensed-matter physics.
Impairment of host adaptive immune response to Candida albicans infection: an in-silico insight on SARS-CoV-2 conspiracy
Authors: KABIR ALI , Das Deepyaman , Podder Soumita 
Published: May 2022

Abstract
Recent evidence reported that SARS-CoV-2 infections might trigger serious consequences in otherwise asymptomatic Candida albicans infections. To elucidate the mechanism of such co-infections, we have reconstructed Protein-protein interaction network (PPINres)with the upregulated genes in blood of C. albicans infected asymptomatic patients and identified 55 Core Genes (CGs). Functional enrichment of CGs evidenced their potential to resist fungal infection. With CGs, Gene Regulatory Network (GRNres) was reconstructed with TF-TF, TF-CG, CG-CG interactions and it exhibited 7 Articulation Points (APs). Mapping these TF-CG interactions with DEGs of COVID-19 revealed that 460 TF-CG pairs and 4 APs are downregulated. Subsequently, functional and pathway enrichment analysis of these gene pairs was performed. Our overall results suggest that weakening of adaptive immune response might pave the path for C. albicans superinfections in COVID-19 patients.
Surface quality study of AZ31B Mg alloy in electric pulse-ultrasonic assisted incremental sheet forming
Authors: Song Zimo , Zhang Haoran , Chu Xingrong , Zhao Zhiyong , Gao Jun 
Published: May 2022

Abstract
Poor surface quality is one of the main problems for the forming and application of magnesium alloys. In this study, electric pulse and ultrasonic vibration were simultaneously applied to the incremental sheet forming (ISF) process of magnesium alloys, and the effect of electric pulse - ultrasonic composite energy field on the surface quality was investigated. Compared with electric pulse assisted forming, composite energy field could improve the surface quality at the condition of higher current frequency (≥ 350HZ), lower step depth (0.1mm) and keep the effective current density less than 30A/mm2. Moreover, although the surface quality can be improved by ultrasonic energy in both directions, the effect is more significantly in direction perpendicular to the feed direction than that in the direction parallel to the feed direction. The repeated rolling caused by ultrasonic vibration is benefit to the rearrangement of the surface gully, and makes the surface profile height distribution relatively uniform. The surface quality also would be aggravated due to the “jumping” effect of the tool head and serious surface oxidative, which caused by excessive temperature increasing at the condition of very current density.
Postoperative Feeding In Neonatal Duodenal Obstruction
Authors: Aroonsaeng Dolrudee , Losty Paul D , Thanachatchairattana Pornsri 
Published: May 2022

Abstract
Background
Findings from manometry studies and contrast imaging reveal functioning gastric physiology in newborns with duodenal atresia and stenosis. Stomach reservoir function should therefore be valuable in aiding the postoperative phase of gastric feeding. The aim of this study was therefore to compare the feasibility of initiating oral or large volume(s) gavage feeds vs small volume bolus feeds following the operation for congenital duodenal anomalies.
Methods
Single-center electronic medical records of all babies with duodenal atresia and stenosis admitted to a university surgical center during January 1997 - September 2021 were analyzed. A fast-fed group (FF) included newborns fed with oral or gavage feeds advanced at a rate of at least 2.5 ml/kg and then progressed more than once a day vs slow-fed group (SF) fed with gavage feeds at incremental rate less than 2.5 ml/kg/day for each time period of oral tolerance or by drip feeds. Total feed volume was limited to 120–150 ml/kg/day in the respective study cohort populations.
Results
51 eligible patients were recruited in the study - twenty-six in FF group and twenty-five in SF group. Statistically significant differences were observed in the ( i ) date of first oral feeds (POD 7.7 ± 3.2 vs 16.1 ± 7.7: p < 0.001) and ( ii ) first full feeds (POD 12.5 ± 5.3 vs 18.8 ± 9.7: p < 0.01) in FF vs SF study groups.
Conclusion
Initial feeding schedules with oral or incremental gavage-fed rates of at least 2.5 ml/kg in stepwise increments and multi-steps per day is wholly feasible in the postoperative feeding regimens of neonates with congenital duodenal disorders. Significant health benefits are thus achievable in these infants allowing an earlier time to acquiring full enteral feeding and their hospital discharge.
Changes in retail food environments around schools over 12 years and associations with overweight and obesity among children and adolescents in Flanders, Belgium
Authors: Smets Vincent , Vandevijvere Stefanie 
Published: May 2022

Abstract
BackgroundChildren have been found to be extra susceptible to the food environment. This research assessed changes in food environments near schools in Flanders between 2008 and 2020 and associations with children’s and adolescents’ weight status. MethodsThe food environment within a 500m and 1000m road network distance to all primary- and secondary schools was mapped using several spatial indicators. A generalized linear modelling approach was used to explore associations between these indicators and weight status of children and adolescents. ResultsFood environments near schools in Flanders were found to be unhealthy in 2020, with a significant increase in fast-food restaurants and convenience stores between 2008 and 2020. Food environments near schools with a higher proportion of children from a poor socio-economic background were found more unhealthy than those near schools with a lower proportion of such children, regardless of the urbanization level. A significant positive association was found between the density of fast food restaurants as well as convenience stores around primary schools and the weight status of children aged <6 years and 6-12 years. The association between the density of fast food restaurants and convenience stores around secondary schools and the weight status of adolescents, aged 13-14 and 15-18 years, was less clear. ConclusionFood environments around schools in Flanders became more unhealthy over time and were associated with children’s weight status.
Mitral paravalvular leak 3D printing from 3D-transesophageal echocardiography – proof of concept and preparation flowchart
Authors: Jędrzejek Marek , Kozłowski Michał , Jadczyk Tomasz , Peszek-Przybyła Ewa , Pysz Piotr , Wojakowski Wojciech , Smolka Grzegorz 
Published: May 2022

Abstract
Paravalvular leaks (PVLs) can be detected in almost 15% of patients after mitral valve prosthesis implantation. This complication can result in congestive heart failure and hemolysis. Despite advancements in non-invasive imaging, percutaneous closure of PVLs is not always successful. Therefore, efforts are made to improve treatment outcomes by using 3D-printed models of defects as pre-procedural support for interventional cardiologists. Retrospectively, 3D-TEE recordings of 8 patients with clinically significant mitral PVLs were analysed. Qlab Software was used to export DICOM images of each PVL channel, including surrounding tissue. Image segmentation was performed in 3D Slicer, a free, open-source software package used for imaging research. Models were printed to actual size with the polyjet Stratasys Objet 30 printer with a transparent, rigid material. Duration of model preparation and printing, as well as total cost were calculated. Mean total time of model preparation was 430,5 ± 196 min. 3D-printing from 3D-TEE is technically feasible. Both shape and location of PVLs are preserved during model preparation and printing. It remains to be tested if 3D-printing would improve outcomes of percutaneous PVL closure.
Analysis of prognostic factors of undifferentiated pleomorphic sarcoma and construction and validation of a prediction nomogram based on SEER database
Authors: Wang Zimao , Liu JinHua , Han Jingjing , Yang Zheng , Wang Qiying 
Published: May 2022

Abstract
Objective:
The purpose of this study was to construct and validate a nomogram for predicting overall survival (OS) in undifferentiated pleomorphic sarcoma (UPS) patients at 3, 5 years after the diagnosis.
Method:
According to the inclusion and exclusion criteria, 1079 patients with UPS were screened from the SEER database and randomly divided into the training cohort (n = 755) and the validation cohort (n = 324). Patient demographic and clinicopathological characteristics were first described, and the correlation between the two groups was compared, using the Kaplan-Meier method and Cox regression analysis to determine independent prognostic factors. Based on the identified independent prognostic factors, a nomogram survival prediction model for OS in UPS patients was established using R language. The nomogram’s performance was then validated using multiple indicators, including the area under the time-dependent receiver operating characteristic curve (AUC), consistency index (C-index), calibration curve, decision-curve analysis (DCA).
Results:
A total of nine factors ,age, tumor location, tumor size, tumor depth, N stage, M stage, tumor grade, surgery and radiotherapy,were included in the nomogram prediction model as independent influence factor. The OS nomogram prediction model in the model group and validation cohort C-index All greater than 0 .75, the AUC was greater than 0.78, and both were higher than the C of the TNM staging system Index and AUC values. Nomogram prediction model and TNM staging system calibration curve with 4 The 5 ° lines were all relatively conforming. Decision curve analysis showed that both the nomogram model and the TNM staging system had clinical net benefits over a wide range of threshold probabilities, and the nomogram had higher clinical net benefits than the TNM staging system as a whole.
Conclusion:
The nomogram survival prediction model can individualize the prediction of 3-year and 5-year OS in patients with UPS, with good discrimination, accuracy and clinical practicability, which can provide a reference for clinicians and patients to make better clinical decisions.
Numerical Analysis onto Thermal Balance Behaviors of Motorized Spindle Unit
Authors: Zhang Yifan , Liu Teng , Gao Weiguo , Zhang Jianjun , Zhang Dawei 
Published: May 2022

Abstract
Generally, the accuracy stability of precision motorized spindle unit is influenced by its structural thermal balance behaviors (power matching degree of spindle structural heat generations - dissipations). For the accurate analysis onto this spindle heat transfer behaviors based on temperature detections, this paper describes a method constructed with the numerical simulation technology and a proposed GA-ELM algorithm. Firstly, heat-fluid-solid coupling FE transient model is established to simulate spindle thermal behaviors, its thermal loads / boundary conditions are initially according to empirical calculations. Secondly, based on spindle temperature detections, these initial values are applied onto thermal simulations and corrected by GA, to make simulated spindle temperatures gradually approach detections. Specially, ELM is adopted to estimate the functional relationships from parent population to child population generated by genetic operators with the increasing fitness values, and the trained ELM model is utilized to ensure the GA faster convergence. Eventually, based on the corrected thermal load / boundary condition values and simulation results, the time-varying power matching conditions of spindle structural heat generation - dissipation are analyzed. This study provides a theoretical basis for the optimization and promotion of spindle structural design and coolant control strategy.
A genome-wide association study implicates the pleiotropic effect of NMUR2 on asthma and COPD
Authors: Do Ah Ra , An Jin , Jo Jinyeon , Kim Woo Jin , Kang Hae Yeon , Lee Sanghun , Yoon Dankyu , Cho You Sook , Adcock Ian M , Chung Kian Fan , Won Sungho , Kim Tae-Bum 
Published: May 2022

Abstract
Asthma and chronic obstructive pulmonary disease (COPD) are two distinct diseases that are associated with chronic inflammation. They share common features in terms of their advanced stages and genetic factors. The main aim of this study was to identify single nucleotide polymorphisms (SNPs) with a pleiotropic effect on both asthma and COPD, and to evaluate the similarities between their genetic underpinnings. We performed a genome-wide association study (GWAS) of asthma and COPD in 7,828 Koreans from three hospitals and investigated genetic correlations. The UK Biobank dataset was used for the replication studies. We found that rs2961757, located near neuromedin U receptor 2 (NMUR2) on chromosome 5, was genome-wide significant (βAsthma-COPD = 0.44, P-valueAsthma-COPD = 3.41 × 10-8), and significant results were replicated with the UK Biobank data (βAsthma-COPD=0.04, P-valueAsthma-COPD = 0.0431). A positive genetic correlation was observed between asthma and COPD (39.8% in the Korean dataset and 49.8% in the UK Biobank dataset). In this study, 40–45% of the genetic effects were common to asthma and COPD. NMUR2 increases the risk of asthma development and suppresses COPD development. This indicates that NMUR2 allows for better differentiation of both diseases, which can facilitate tailored medical therapy.
Diverse analytical wave solutions and dynamical behaviors of the new (2+1)-dimensional Sakovich equation emerging in fluid dynamics
Authors: Kumar Sachin , RANI SETU , Mann Nikita 
Published: May 2022

Abstract
Under investigation, this paper constructs an improved and comprehensive class of analytical wave solutions to the (2+1)-dimensional Sakovich equation, a nonlinear evolution equation that plays a remarkable role in condensed physics, fiber optics, and fluid dynamics. By applying relatively, two renewed techniques named Lie symmetry analysis and extended Jacobian elliptic function expansion method, some standard class of new and wide-spectrum closed-form solutions are established in terms of trigonometric, hyperbolic, and Jacobi elliptic functions. These ascertained solutions contain several ascendant parameters that play a crucial role in describing the inner mechanism of a given physical model. Therefore, the obtained wave solutions are demonstrated graphically by three- and two-dimensional graphics using Mathematica. In addition, a couple of varieties of solutions, including multi soliton, periodic soliton, Bell-shaped, and parabolic profile, are depicted for the suitable values of the included parameters. Finally, it must be noted that the variation in obtained wave profiles by the change in subsidiary parameters reveals the parameter effects on the wave. This study ensures that the forgoing techniques are practical and may be used to seek the solitary solitons to a diversity of nonlinear evolution equations (NLEEs).
A survey study of the adherence to the 2020 ACC/AHA heart failure guideline in low-middle income countries (Gaza Strip as an example)
Authors: Alsaiqali Mahmoud , Al-Saikaly Ghassan , AboAbdo Mohammad , mezead Mohammad , Mansour Zakaria , AlZaharna Alaaeddin , Al-Sadawi Mohammed , Mhanna Mohammed , Habib Mohammed 
Published: May 2022

Abstract
BackgroundAcute heart failure is associated with higher post-discharge mortality, especially in low-middle income countries (LMIC). There are limited studies on adherence to the recommended post-discharge care guidelines in these settings.ObjectivesTo assess adherence to the 2020 ACC/AHA inpatient heart failure performance and quality measure in Gaza Strip, Palestine.MethodsThe study was a cross-sectional survey study. We chose a stratified random sample from the three different geographical areas across Gaza Strip with numbers proportional to the size of each region. Patients selected were adults (>18 years) admitted to the various hospitals for acute decompensated heart failure between 4/2021 and 12/2021. We collected data through chart review. Measures were β blockers, ACEi/ARB and MRA prescription, and outpatient follow-up. Results reported as proportion with 95% CI.ResultsThe sample size was 155 patients. The mean age was 64 years. 59% were males. The mean length of stay was 2.8 days. β blockers were prescribed to 85.1% [79.5,90.8] of patients. For ACEi/ARB use, it was 42.7% [34.9,50.5]. For MRA, after excluding ineligible patients, it was prescribed in 48.5% [39.9, 57.2]. None of the patients were prescribed hydralazine/nitrate. Only 30.1% [ 23.6, 38.1] of patients had an outpatient appointment. The median time between discharge and appointment date was 22 days. Only 9.7% [5.0,14.3] of patients were discharged with all quality measures fulfilled.Conclusion There are considerable gaps in the post-discharge care of heart failure patients in the Gaza Strip. There is a need to develop local care guidelines to improve care.
Expression and clinical significance of PRKDC in lung cancer based on bioinformatics analysis
Authors: Guo Yikun , Yang Mengxia , Liu Xingxing , Liu Yanbin , Yan Jun 
Published: May 2022

Abstract
Objective: To investigate the expression and prognostic significance of protein kinase DNA activated catalytic subunit (PRKDC) in non-small cell lung cancer (NSCLC). Methods: oncomine, ualcan, human protein Altas, Kaplan Meier plot and c-bioportal databases were searched to analyze the mRNA expression, protein expression, clinicopathological parameters, prognosis, survival and gene mutation of PRKDC in NSCLC and normal lung tissues.Results: the overexpression of PRKDC mRNA and protein in pathological tissues was significantly correlated with the stage of lung adenocarcinoma (luad) and lung squamous cell carcinoma (lusc), smoking habits, gender, race and lymph node metastasis, and significantly correlated with the shortening of overall survival rate (OS) of NSCLC patients. At the same time, PRKDC had a high mutation rate in NSCLC（ LUAD:23% ，LUSC:19% ）The patients with luad had shorter OS and disease-free survival Survival rate (DPS) was significantly correlated.Conclusion: PRKDC may be a biomarker for the prognosis of NSCLC patients.