bluuebunny/crossref_metadata_2025_split huggingface dataset:
Gene therapy preferences and informed decision‐making: Results from a National Hemophilia Foundation Community Voices in research survey
Authors: Limjoco Jacqueline , Calatroni Agustin , Aristizabal Paula , Thornburg Courtney D. 
Published: December 2022

AbstractIntroductionTo inform education and treatment discussions, it is important to understand how persons with haemophilia prefer to learn about and discuss new therapies and to identify variables that influence decision‐making.AimThe aim of this study was to evaluate preferences and variables which influence decision‐making related to gene therapy and other novel haemophilia therapies.MethodsAn online survey was sent to men with severe haemophilia enrolled in the National Hemophilia Foundation Community Voices in Research online platform for patient‐powered research.ResultsOne hundred four men completed the survey including 33% Hispanics, 96 who had had not gene therapy and 71/96 (74%) who were on prophylaxis. Ninety‐five percent were somewhat or very familiar with gene therapy. Men with haemophilia obtain information about new therapies from several sources, most commonly their haemophilia treatment team, patient advocacy groups and self‐study. Participants identified safety and efficacy as well as other educational needs to inform decision‐making. Of those without prior gene therapy, 73% indicated a high likelihood of considering gene therapy. Hispanic ethnicity and government‐issued insurance were associated with a higher likelihood of considering gene therapy as a treatment option.ConclusionHaemophilia Treatment Centers and patient advocacy groups must be able to educate persons with haemophilia about aspects of novel therapies which are important to the individual, especially short‐ and long‐term safety and efficacy. Further research is needed to determine how patient activation and health literacy influence decision‐making and how to achieve equitable access and valid informed consent for novel therapies.
Perceived cognitive functioning in breast cancer patients treated with chemotherapy compared to matched healthy women: Evidence from a Portuguese study
Authors: Oliveira Ana F. , Torres Ana , Teixeira Ricardo J. , Monteiro Sara , Pereira Anabela , Santos Isabel M. 
Published: December 2022

AbstractAimCognitive concerns are one of the most frequently reported symptoms by breast cancer survivors. This study aimed to evaluate perceived cognitive functioning in Portuguese women with breast cancer treated with chemotherapy.MethodsA cross‐sectional study enrolling 146 women (73 with breast cancer and 73 healthy) was conducted from August to October 2017, invited to participate through online dissemination. Participants completed self‐reported questionnaires to collect sociodemographic and clinical data and assess perceived cognitive functioning and psychological adjustment variables (anxiety and depression).ResultsCompared to healthy women, women with breast cancer showed significantly lower scores on the Functional Assessment of Cancer Therapy‐Cognitive Function (FACT‐Cog) subscales and higher levels of depression. Both groups showed significant negative correlations between perceived cognitive functioning and anxiety and depression. Health status and depression seem to better explain perceived cognitive functioning, with health status adding significantly more explained variance beyond sociodemographic and psychological adjustment variables.ConclusionThe current findings provide evidence for the existence of more cognitive complaints among Portuguese women with breast cancer, compared to healthy individuals. Anxiety, depression, age and education also explain perceived cognitive functioning. Considering that health status and psychological adjustment seem to significantly explain perceived cognitive functioning, special attention should be given by health‐care professionals, including nurses, to designing clinical interventions for breast cancer patients to help manage cognitive impairment.
Negative situation appraisal and mental well‐being among refugees in Germany: Serial mediation by religious coping and sense of coherence
Authors: Skalski‐Bednarz Sebastian Binyamin , Konaszewski Karol , Muszyńska Jolanta , Maier Kathrin , Surzykiewicz Janusz 
Published: December 2022

AbstractIt has been widely demonstrated that pre‐ and post‐migration experiences can be highly traumatic for refugees. The purpose of this study was to assess the mediating effects of religious coping and sense of coherence on the association of negative dysfunctional situation appraisal and mental well‐being among refugees. Paper surveys were completed by 600 people representing various refugee groups (mostly from Mashreq Countries) in German Bavaria, aged 18–65. Mediation analysis revealed that negative religious coping and sense of coherence singly and serially mediated the relationship between negative dysfunctional situation appraisal and well‐being, whereas positive religious coping did not have statistically significant relationships with these variables. The data obtained suggest that the negative religious coping style and sense of coherence are two important targets for future experimental studies, and interventions on them may bring the synergistic effect on improving mental well‐being in refugees.
Self‐reported gaps in care coordination and preventable adverse outcomes among older adults receiving home health care
Authors: Sterling Madeline R. , Lau Jennifer , Rajan Mangala , Safford Monika M. , Akinyelure Oluwasegun Philip , Kern Lisa M. 
Published: December 2022

AbstractBackgroundOlder adults see multiple outpatient providers and increasingly use home health care (HHC) services. Previous studies attempting to draw inferences about the association between HHC use and patient outcomes have been mixed. Whether HHC is associated with care coordination and how both influence outcomes are unknown. In addition, prior studies have not taken the patient perspective into account. We examined the association between receiving HHC and self‐reported gaps in care coordination and separately, preventable adverse outcomes.MethodsThe analysis for this cross‐sectional study was conducted between October 2021 and June 2022, using data on 4296 Medicare beneficiaries from the Reasons for Geographic and Racial Differences in Stroke (REGARDS) study who completed a survey on care coordination from 2017 to 2018. The associations between the receipt of HHC and two outcomes (a gap in care coordination, and separately, a preventable adverse event) were examined with Poisson models with robust standard errors. Potential confounders were accounted for through propensity score‐based inverse probability weighting.ResultsAmong 4296 participants, 430 (10%) received HHC and they were older and had more comorbidities and ambulatory visits than those without HHC. HHC was not associated with differences in self‐reported gaps in care coordination (33.3% HHC vs. 32.5% no‐HHC, p = 0.70). HHC recipients reported more preventable drug–drug interactions (9.1% vs. 4.0%, p < 0.001) but not more preventable ED visits or hospital admissions. In IPW‐adjusted models, HHC was not associated with gaps in care coordination (p = 0.60) but was associated with double the risk of a preventable adverse outcome (aRR 2.06; CI: 1.37, 3.10, p < 0.001).ConclusionsHHC recipients were significantly more likely (than those without HHC) to report a potentially preventable adverse event (particularly a drug–drug interaction), suggesting an opportunity to improve patient safety by leveraging the observations of older adults receiving HHC.
Disentangling social impacts in global value chains through structural path analysis: Investigating forced labor in the cotton industry
Authors: García‐Alaminos Ángela , Monsalve Fabio , Zafrilla Jorge 
Published: December 2022

AbstractThis analysis proposes an analytical method to trace the precise pathways through which impacts from a specific origin are disseminated worldwide and embodied in high‐income nations' consumption. Our methodological approach is based on a multi‐regional input–output model developed using EXIOBASE data for 2019. The model is extended with the structural path analysis (SPA) methodology, which allows us to trace and quantify the critical interactions in the impacts' dissemination process from their origin until reaching their destination as final demand in a specific industry and region. The SPA method is explored both in gross and net terms as complementary perspectives to disentangle the complexity of global value chains, which is the main contribution of our approach. The net assessment accounts just for interindustry transactions, whereas the gross analysis considers all steps of the value chain, even those occurring at an intraindustry level. In this work, we analyze a case study to expose the features of this proposal, which focuses on assessing the global reach of forced labor in the cotton industry in the two leading worldwide cotton producers. Textile global value chains are intricate and complex, making it hard to trace the negative social impacts linked to them. Therefore, a deeper understanding of how forced labor is disseminated worldwide until reaching developed nations is necessary to shed light on the social sustainability debate. Although this kind of forced labor seems to be a regional affair, our results show that more than 13% of the estimated forced workers are attributed to the European Union and the United States consumption, respectively, with apparel, footwear, and textiles as key goods embodying these workers. After analyzing the specific paths of dissemination linked to the fashion demand of the European Union and the United States, our key findings show the predominant role of the Chinese and Indian textile industries in most paths given the high number of intrasectoral transformations inside this sector. We also show that forced labor in the Chinese cotton industry is even more distant to the final consumer than usual unskilled labor, which is an additional obstacle to its traceability.
Developing a material flow monitor for the Netherlands from national statistical data
Authors: Delahaye Roel , Tunn Vivian S. C. , Tukker Arnold 
Published: December 2022

AbstractEffective monitoring of national circular economy policies requires consistent, national databases of material flows and environmental impacts. Yet, databases and indicators developed so far are scattered and inconsistent. To tackle this problem, Statistics Netherlands (CBS) developed a material flow monitor (MFM) that integrates existing statistics using principles of the System of Environmental Economic Accounting (SEEA). The MFM is the physical counterpart of the Dutch supply and use tables (SUT) of the National Accounts and is also referred to as physical SUT (P‐SUT). The P‐SUT captures national resource extraction, product imports and exports, product flows between economic sectors, as well as emissions and waste streams resulting from economic activities. Our work illustrates how a statistical office can use and enrich its formal statistical data to compose an MFM consistent with the National Accounts and how indicators can be extracted with a case study on the bio‐based economy. We contribute a clear step‐by‐step description of the method and the used datasets. This supports the development of MFMs by other statistical offices and researchers, thereby enabling consistent and comparable circular economy monitoring.
Adherence and concordance among Q‐Graders in the sensory analysis of coffees
Authors: Fioresi Deusélio Bassini , Ramos Alessandro Coutinho , Bertolazi Amanda Azevedo , Pereira Lucas Louzada 
Published: December 2022

AbstractIn any sensory analysis, it is important to investigate whether the tasters agree with each other, because they can assign scores in a correlated, but not the concordant way. This work investigated the adherence and the concordance among tasters of the coffee sensorial analysis of the Arabica and Conilon varieties, and their impacts on the final quality ratings of these varieties. The samples were obtained from regions of the Espirito Santo state, Brazil, and were evaluated by six tasters, with five repetitions and four treatments, totaling 120 observations. Nonparametric statistical techniques were used to compare the distribution of grades, and Lin's concordance coefficient was used to analyze the concordance among tasters. The Factor Analysis by Principal Components revealed that different distributions and disagreements among tasters affect, mainly, the sensorial attributes body, overall, flavor and acidity, thus changing the final result of the evaluation and, consequently, the final quality ratings of the products. These results allow new approaches in conducting the coffee sensorial analysis.Practical applicationsThe production of specialty coffees brings an excellent opportunity to add value, especially for small producers, or family producers on properties where the relief and climate make harvesting difficult, such as the mountain regions of the state of Espírito Santo, Brazil. This new perspective allows small producers to participate in contests to promote their product, which can be sold at different prices in the national and international markets. However, if the quality assessment methods suffer some kind of interference, the final evaluation may be unfair, or at least, incompatible with the reality of each product. The objective of this study is not to disqualify the current evaluation methods, but to justify improvements in these methods, which must be appreciated and improved by evaluators in the area.
Progression of lipase activity and pancreatic lipase immunoreactivity in dogs hospitalized for acute pancreatitis and correlation with clinical features
Authors: Cueni Claudia , Hofer‐Inteeworn Natalie , Kümmerle‐Fraune Claudia , Müller Claudia , Kook Peter Hendrik 
Published: December 2022

AbstractBackgroundLipase activity and pancreatic lipase immunoreactivity (PLI) have not been compared in dogs hospitalized for acute pancreatitis (AP).ObjectivesTo describe the progression of lipase activity and PLI, and correlations with clinicopathologic features in dogs with AP.AnimalsThirty‐nine dogs with AP based on clinical signs and lipase activity >350 U/L (reference interval [RI], 24‐108 U/L).MethodsRetrospective study. Lipase activity (LIPC Roche), PLI (SpecPL), and clinical signs were recorded daily. Admission (d1) data (clinical, laboratory, and ultrasound [US] findings), and clinical signs during hospitalization (d2‐d3) were assessed for correlation with lipases.ResultsMedian (range) duration of clinical signs before presentation was 2 days (1‐7 days). Median (range) lipase activity and PLI at d1 were 1070 U/L (range, 357‐1500 U/L) and 1111 μg/L (range, 292‐1500 μg/L). Strong correlation between assays at d1 (rs0.96;P < .0001; n = 39), remained equally strong on d2 (rs0.964;P < .0001; n = 39), and d3 (rs0.966;P < .0001; n = 22). On d2, lipase activity and PLI were within RI in 13/39 (33%) and 18/39 (46%) of cases. Lipase activities were minimally increased (median, 124 U/L) in 5 dogs with d2 PLI <200 μg/L. On d3, 4 more dogs had normal lipase activity and PLI, and the nature and magnitude of change were always the same for both assays. Clinical signs were not associated with lipases. Only a hyperechoic mesentery, but not an US diagnosis of AP, correlated significantly with lipase activity and PLI.Conclusions and Clinical ImportanceLipase decreases rapidly to near or within RI within 2 days of treatment in the majority of dogs with AP. Both lipase assays yielded virtually identical results. Mesenteric echogenicity may be an early marker of AP in dogs.
Whitewashing white permanence: The (dis)/(re)membering of white corporeality in early modern England
Authors: Chapman Matthieu 
Published: December 2022

AbstractIn early modern English drama, black flesh is remarkable. In the Shakespeare canon, the visibly black flesh of the eponymous Moor of Venice inOthelloand the villainous Aaron inTitus Andronicushas been the subject of scholarly analysis for centuries. Yet, in a field that has placed so much emphasis on flesh marked by color, unmarked flesh is imbued with assumptions of whiteness that make unremarkable, a privilege that renders it unthought and uncritiqued, processes that contribute to the normativity of whiteness as inextricable from subjectivity. This rhetoric of whiteness as largely unremarkable continues to influence our modern conceptualizations of what Shakespeare looks like both in our minds and on the stage. Too often, modern productions of Shakespeare engage in casting practices that elide important early modern identity distinctions in service of contemporary white supremacy. For instance, national identity—the difference between being English, Irish, Scottish, French, etc—mattered both for character and actor on the Early Modern English stage. Yet, these distinctions fade into the fringes of memory when casting today's productions, allowing directors to include and exclude bodies based on modern conceptions of racial difference and mis‐remembering of whiteness as a coherent and stable early modern identity. But whiteness was neither so stable nor so stoic in Shakespeare's day or in the works of Shakespeare as our modern theatrical culture continually mis‐remembers and re‐performs. This essay engages with the ways in which the modern theatre mis‐remembers Shakespeare in relation to whiteness to reinforce white supremacy. This essay uses contemporary theories of Afro‐Pessimism and Black Critical Theory to destabilize the mythology of white permanence that undergirds Renaissance history. I argue that the notions of the stable white corporeal whole that scholars and artists assume of the majority of Shakespeare's characters requires an anachronistic reading of whiteness that is the product of chattel slavery and a paradigm that relies on the destruction of black flesh for the unified white body to gain corporeal coherence. The essay concludes with a critique of epistemology arguing that this forgetting of the historical dismemberment of white flesh makes us mis‐remember the role of whiteness in our present.
Limits of semistatic trading strategies
Authors: Nutz Marcel , Wiesel Johannes , Zhao Long 
Published: December 2022

AbstractWe show that pointwise limits of semistatic trading strategies in discrete time are again semistatic strategies. The analysis is carried out in full generality for a two‐period model, and under a probabilistic condition for multiperiod, multistock models. Our result contrasts with a counterexample of Acciaio, Larsson, and Schachermayer, and shows that their observation is due to a failure of integrability rather than instability of the semistatic form. Mathematically, our results relate to the decomposability of functions as studied in the context of Schrödinger bridges.
Impact evaluation of a community nutrition and livelihood program on child nutrition in rural Bangladesh
Authors: Kang Yunhee , Prihartono Indira , Hossain Md. Iqbal , Min Shinhye , Kim Heeyeon , Cho Yoonho , Han Seungheon , Kim Hee Sun , Biswas Jaganmay P. 
Published: December 2022

AbstractGiven the high prevalence of child undernutrition in Bangladesh, multi‐sectoral approaches involving livelihood promotion have potential to mitigate the burden of undernutrition. This study examined the impact of an economic development (ED) program providing poultry assets, gardening skills and saving training added to the Positive Deviant (PD)/Hearth program (PDH/ED), compared to PD/Hearth only (PDH). A total of 1029 children who attended PD/Hearth sessions in September–November 2018 at 6–13 months of age were enrolled in the cohort study in July–August 2019. The cohort, comprised of 532 children in the PDH/ED group and 593 children in the PDH group, was reassessed in November 2020. The program impact on child nutrition, food security, crop production, dietary quality and household income was estimated using a difference‐in‐differences approach accounting for the sociodemographic differences between PDH/ED and PDH groups. Compared to the PDH group, the PDH/ED group showed increases in child dietary diversity score (DDS) (+0.32), child minimum dietary diversity (13.7 percentage points [pp]), and maternal DDS (+0.28) (all p < 0.05). From 2019 to 2020, the PDH/ED households improved food security by 12.6 pp and diversified crop production (bananas (9.7 pp), papaya (11.1 pp), carrots (3.8 pp) and lemons (5.9 pp)), and increased the proportion of annual income ≥60,000 Taka by 12.4 pp and last month income ≥5000 Taka by 7.8 pp, compared to PDH group (all p < 0.05). However, there was no impact on child nutritional status, morbidity, livestock ownership and total annual/last income. Incorporating an ED program into nutrition programming could benefit food security and dietary diversity in rural Bangladesh.
Low genetic diversity and population structuring of Amblyomma hebraeum and Rickettsia africae from coastal and inland regions in the Eastern Cape Province of South Africa
Authors: Pillay Alicia , Nyangiwe Nkululeko , Mukaratirwa Samson 
Published: December 2022

AbstractAmblyomma hebraeum is the main vector of Rickettsia africae, the causative agent of African tick bite fever in southern Africa. Because pathogen dispersal is known to be influenced by tick adaptations to climate or host species, this study aimed to analyse the genetic diversity of A. hebraeum and R. africae infection of ticks collected from cattle in the Eastern Cape province of South Africa. DNA was extracted, amplified, and sequenced for the COI and ITS2 markers from A. hebraeum samples and the 17 kDa and ompA genes for rickettsial detection. Between six and ten haplotypes were identified from 40 COI and 31 ITS2 sequences; however, no population structuring was observed among sites (ΦST = 0.22, p < 0.05). All A. hebraeum isolates clustered with southern Africa GenBank isolates. Rickettsia africae was detected in 46.92% (95% CI = 41%–53%, n = 260) of ticks. All R. africae isolates clustered with strain PELE and Chucks, which were reported previously from South Africa. These results confirm that A. hebraeum populations are undergoing a recent population expansion driven by cattle movement, facilitating local and long dispersal events across the Eastern Cape province.
Levels and sources of adolescents' sexual knowledge in traditional societies: A cross‐sectional study
Authors: Jabareen Raifa , Zlotnick Cheryl 
Published: December 2022

AbstractGender rules, patriarchy, and cultural taboos on sexual issues in traditional societies may compel adolescents to seek sexual information from informal and inadequate sources. The aim of this cross‐sectional study was to determine whether the level and sources of sexual knowledge differed by gender in the traditional community comprising Palestinian‐Israeli high school students. Guided by the Human Ecological Systems Model and informed by a community‐based participatory research approach, a convenience sample of high school students (n = 558) was recruited. Although findings indicated that both boys and girls had low levels of sexual knowledge, the areas of knowledge deficits varied by gender. The model demonstrated good fit for boys but not for girls. Post hoc analyses indicated that girls obtained sexual knowledge solely from close family members, while boys obtained sexual knowledge from multiple sources. Very few students of either gender obtained sexual knowledge from doctors or nurses, but with community input on cultural issues, nurses can play a pivotal role in creating comprehensive, school‐based sex education for adolescents living in traditional societies.