bluuebunny/crossref_metadata_2025_split huggingface dataset:
The accuracy of a novel image‐guided hybrid robotic system for dental implant placement: An in vitro study
Authors: Tao Baoxin , Feng Yuan , Fan Xingqi , Lan Kengliang , Zhuang Minjie , Wang Shigang , Wang Feng , Chen Xiaojun , Wu Yiqun 
Published: August 2022

AbstractBackgroundThis in vitro study aims to evaluate the accuracy of dental implant placement by a novel image‐guided hybrid robotic system for dental implant surgery (HRS‐DIS).MethodsThe HRS‐DIS with a 5 degree of freedom (DOF) serial manipulator and a 6 DOF Stewart platform was developed. To evaluate the accuracy of repeated drilling, the holes were prepared twice with a 2.2 mm drill. To evaluate the accuracy of dental implant placement, the entry, exit and angle deviations of dental implants were measured.ResultsTwenty‐four holes were prepared twice, and mean (±SD) of diameters were measured as 2.2 ± 0.02 mm. A total of 160 dental implants were placed in 32 phantoms by HRS‐DIS. The mean (±SD) of the entry, exit and angle deviation were 0.8 ± 0.54 mm, 0.87 ± 0.54 mm and 1.0 1 ± 0.44°, respectively.ConclusionsThe results of the in vitro study preliminarily validated that the HRS‐DIS could provide a high accuracy for dental implant surgery.
Comparison of advanced semi‐probabilistic methods for design and assessment of concrete structures
Authors: Novák Lukáš , Červenka Jan , Červenka Vladimír , Novák Drahomír , Sýkora Miroslav 
Published: August 2022

AbstractThis paper presents the comparison of advanced semi‐probabilistic methods for the design and assessment of concrete structures represented by mathematical models solved by non‐linear finite element methods. The special attention is given to the advanced methods focused on the estimation of the coefficient of variation of structural resistance. Numerical examples represent a replication of laboratory experiments of beams with different failure modes. The obtained results are discussed with respect to the accuracy of the employed methods and the influence of the assumed statistical correlation among basic variables. Simplified methods give a good estimation of the design values, though their accuracy is dependent on the type of the failure mechanism. Moreover, it is shown that mutual correlations among random variables may significantly affect the design value of resistance, and they should be carefully defined and modeled.
Influence of tibial plateau levelling osteotomy on the tensile forces sustained by ligaments in cranial cruciate ligament‐intact canine stifles: An ex vivo pilot study
Authors: Shimada Masakazu , Takagi Tetsuya , Kanno Nobuo , Yamakawa Satoshi , Fujie Hiromichi , Hara Yasushi 
Published: August 2022

AbstractBackgroundTibial plateau levelling osteotomy (TPLO) changes the anatomical tibial conformation and might alter the positional relationship of the ligaments comprising the stifle joint. As a result, it is expected to affect the tensile force of the ligaments. However, studies analyzing the details of the effect of osteotomy are limited.ObjectivesTo evaluate the influence of TPLO on the tensile force on the stifle ligaments in the intact canine stifle using a six‐degree‐of‐freedom (6‐DOF) robotic testing system.MethodsEight stifles were categorised into the reference group and nine stifles into the TPLO group. The stifles were then analysed using a 6‐DOF robotic joint biomechanical testing system. The stifles were applied 30 N at cranial, caudal, and compression loads and 1 Nm at the internal and external torque loads (the load applied to the tibia relative to the femur) on extension, at 135° and 120°, respectively. The tensile force placed on the cranial cruciate ligament (CrCL), the caudal cruciate ligament, the medial collateral ligament, lateral collateral ligament and the total tensile force placed on the four ligaments was calculated under each load.ResultsFor the caudal load applied to the tibia relative to the femur, the CrCL tensile force in the TPLO group was lower than that in the reference group at 120° (p = 0.02). The CrCL tensile force in the TPLO group was lower than that in the reference group at 120° (p < 0.01) for the compression load. Regarding the cranial, internal, and external load, the CrCL tensile force remains unchanged between both groups at each angle.ConclusionsTPLO reduces CrCL tensile force during compression and caudal force application. TPLO may reduce tensile forces contributing to CrCL rupture.
Bone meal ingestion in dogs: 255 Cases reported to the Veterinary Poisons Information Service
Authors: Little Annika , Bates Nicola , Tizzard Zoe , Savage Claire , Trehy Mary 
Published: August 2022

AbstractBone meal is a widely used fertiliser, and its ingestion in dogs is common, presumably because they are attracted by the odour. In a case series of 255 cases reported to the Veterinary Poisons Information Service, 47.1% of dogs remained well. Clinical signs were reported in 52.9% and were predominantly gastrointestinal, particularly vomiting and diarrhoea. Some dogs also displayed lethargy (14.9%) and abdominal pain (5.9%). Signs were typically mild, but in a small number of cases, gastrointestinal impaction and/or perforation (1.2%) occurred. Of the 135 symptomatic dogs that ingested bone meal, 132 recovered (51.8%), two were euthanased (0.8%) and one died (0.4%). Two dogs with gastrointestinal complications following bone meal ingestion are described in detail. Both had prolonged gastrointestinal signs, and exploratory coeliotomy confirmed gastrointestinal impaction with perforation in one case and necrosis of the gastric wall in the other. Both dogs were euthanased perioperatively due to poor prognosis.
Review of automated time series forecasting pipelines
Authors: Meisenbacher Stefan , Turowski Marian , Phipps Kaleb , Rätz Martin , Müller Dirk , Hagenmeyer Veit , Mikut Ralf 
Published: August 2022

AbstractTime series forecasting is fundamental for various use cases in different domains such as energy systems and economics. Creating a forecasting model for a specific use case requires an iterative and complex design process. The typical design process includes five sections (1) data preprocessing, (2) feature engineering, (3) hyperparameter optimization, (4) forecasting method selection, and (5) forecast ensembling, which are commonly organized in a pipeline structure. One promising approach to handle the ever‐growing demand for time series forecasts is automating this design process. The article, thus, reviews existing literature on automated time series forecasting pipelines and analyzes how the design process of forecasting models is currently automated. Thereby, we consider both automated machine learning (AutoML) and automated statistical forecasting methods in a single forecasting pipeline. For this purpose, we first present and compare the identified automation methods for each pipeline section. Second, we analyze these automation methods regarding their interaction, combination, and coverage of the five pipeline sections. For both, we discuss the reviewed literature that contributes toward automating the design process, identify problems, give recommendations, and suggest future research. This review reveals that the majority of the reviewed literature only covers two or three of the five pipeline sections. We conclude that future research has to holistically consider the automation of the forecasting pipeline to enable the large‐scale application of time series forecasting.This article is categorized under:Technologies > Machine LearningTechnologies > PredictionAlgorithmic Development > Spatial and Temporal Data Mining
Reduction with degenerate Gram matrix for one-loop integrals
Authors: Feng Bo , Hu Chang , Li Tingfei , Song Yuekai 
Published: August 2022

Abstract
An improved PV-reduction (Passarino-Veltman) method for one-loop integrals with auxiliary vector R has been proposed in [1, 2]. It has also been shown that the new method is a self-completed method in [3]. Analytic reduction coefficients can be easily produced by recursion relations in this method, where the Gram determinant appears in denominators. The singularity caused by Gram determinant is a well-known fact and it is important to address these divergences in a given frame. In this paper, we propose a systematical algorithm to deal with this problem in our method. The key idea is that now the master integral of the highest topology will be decomposed into combinations of master integrals of lower topologies. By demanding the cancellation of divergence for obtained general reduction coefficients, we solve decomposition coefficients as a Taylor series of the Gram determinant. Moreover, the same idea can be applied to other kinds of divergences.
Nanoscale organization of the MHC I peptide-loading complex in human dendritic cells
Authors: Koller Nicole , Höllthaler Philipp , Barends Martina , Döring Marius , Spahn Christoph , Durán Verónica , Costa Bibiana , Becker Jennifer , Heilemann Mike , Kalinke Ulrich , Tampé Robert 
Published: August 2022

AbstractDendritic cells (DCs) translate local innate immune responses into long-lasting adaptive immunity by priming antigen-specific T cells. Accordingly, there is an ample interest in exploiting DCs for therapeutic purposes, e.g., in personalized immunotherapies. Despite recent advances in elucidating molecular pathways of antigen processing, in DCs the exact spatial organization of the underlying processes is largely unknown. Here, we unraveled the nanoscale organization of the transporter associated with antigen processing (TAP)-dependent peptide-loading machinery in human monocyte-derived DCs (moDC). We detected an unexpected accumulation of MHC I peptide-loading complexes (PLCs) and TAP-dependent peptide compartmentalization in protrusions of activated DCs. Using single-molecule localization microscopy we revealed that PLCs display homogeneously sized assemblies, independent of the DC activation status or cellular localization. Our data indicate that moDCs show augmentation of subcellular PLC density during DC maturation. We observed a twofold density increase in the cell body, while an even fourfold accumulation was detected in the tips of the protrusions at the mature DC stage in comparison to immature DCs. In these tip regions, PLC assemblies are found along highly compressed tubular ER networks. These findings provide novel insights into nanoscale organization of the antigen presentation machinery, and open new perspectives on the T cell stimulatory capacity of DCs.
Test of a PSHA Map of China with Fortification Benefit Evaluation
Authors: Tao Zhengru , Tao Xiaxin , Chen Weijue , Tao Zhiguo 
Published: August 2022

AbstractA path for testing a probabilistic seismic hazard assessment (PSHA) map is presented in this paper via the evaluation of fortification benefit with two indices, economic benefit and safety benefit. The effect of fortification intensity on the vulnerability of the engineering structure is emphasized in the damage estimation of the evaluation. The expected losses and casualties are calculated based on the total areas in each of the five damage states with local parameters. The result of a case study of the 1990 PSHA map of China shows that the expected total reduction of loss from the damage to brick concrete and reinforced concrete buildings constructed during the in-service period of the map and damaged in the subsequent destructive earthquakes is RMB 216.5 billion. Thus the expected economic benefit is RMB 17.5 billion in comparison to the additional fortification cost of RMB 199.0 billion. The expected casualty reductions are 20,838 fewer deaths and 77,801 fewer serious injuries. This indicates that the implementation of the 1990 PSHA map has indeed played a beneficial role in earthquake disaster mitigation. The evaluation result of the marginal benefit of fortification, in terms of increasing or decreasing the fortification intensities by one degree further for the whole country, shows that the fortification level adopted in China is appropriate as a whole.
Acceptability of multimodal pelvic floor physical therapy to treat dyspareunia after gynecological malignancies: a qualitative study of women’s views and experiences
Authors: Cyr Marie-Pierre , Dostie Rosalie , Camden Chantal , Dumoulin Chantale , Bessette Paul , Pina Annick , Gotlieb Walter Henry , Lapointe-Milot Korine , Mayrand Marie-Hélène , Morin Mélanie 
Published: August 2022

Abstract
Introduction and hypothesis
Multimodal pelvic floor physical therapy (PFPT) is recommended after gynecological malignancies to treat dyspareunia. However, data to strongly support its implementation in the cancer care continuum are lacking. The aim of this study was to explore the views and experiences of gynecological cancer survivors with dyspareunia regarding the acceptability of multimodal PFPT.

Methods
This qualitative study was conducted with the participants (n = 28) of a study investigating a 12-week multimodal PFPT treatment. Individual semi-structured telephone interviews served to collect qualitative data pertaining to women’s views and experiences of the treatment they received. Interviews were recorded and transcribed for analysis using the interpretative description framework.

Results
Our cohort described the appropriateness of the treatment in terms of modalities, physical therapist, care delivery, and intensity (Theme 1). While the intensity was reported as demanding by a few, all participants stressed that it was relevant to see significant improvements (Theme 2). In addition to the treatment characteristics and women’s beliefs and attitudes, noticing the treatment effects motivated their participation (Theme 2). Women expressed being highly satisfied with the treatment based on their positive experiences and the balance between their efforts and the results they obtained (Theme 3). As a result, they all recommended this treatment (Theme 3).

Conclusions
This is the first study to examine the acceptability of multimodal PFPT in the context of gynecological malignancies. This treatment was found acceptable and can be offered to gynecological cancer survivors.
The Efficacy and Safety of Intravenous Iron in Geriatric Hip Fracture Surgeries: A Systematic Review and Meta‐Analysis
Authors: Cao Mu‐Min , Chi Jia‐Yu , Zhang Yuan‐Wei , Sheng Ren‐Wang , Gao Wang , Zhao Ya‐Kuan , Rui Yun‐Feng 
Published: August 2022

AbstractBackgroundWith the increasing evidence provided by recent high‐quality studies, the intravenous iron appears to be a reliable therapy for blood administration in geriatric patients with hip fractures. Here, this systematic review and meta‐analysis were aimed to assess the effectiveness and safety of intravenous iron in geriatric patients sustaining hip fractures.MethodsPotential pertinent literatures evaluating the effects of intravenous iron in the geriatric patients undergoing hip fractures were identified from Web of Science, PubMed, Embase, and Scopus. We performed a pairwise meta‐analysis using fixed‐ and random‐effects models, and the pooling of data was carried out by using RevMan 5.1.ResultsFour randomized controlled trials and four observational studies conform to inclusion criteria. The results of meta‐analysis showed that intravenous iron reduced transfusion rates compared to the control group, yet the result did not reach statistical significance. The intravenous iron was related to lower transfusion volumes, shorter length of stay, and a reduced risk of nosocomial infections. And there was no significant difference in terms of the mortality and other complications between the treatment group and the control group.ConclusionCurrent evidence suggests that intravenous iron reduces the transfusion volume, length of hospital stay, and risk of nosocomial infections. It takes about 7 days for intravenous iron to elevate hemoglobin by 1 g/dl and about 1 month for 2 g/dl. The safety profile of intravenous iron is also reassuring, and additional high‐quality studies are needed.
Taxonomic Characterization, Antiviral Activity and Induction of Three New Kenalactams in Nocardiopsis sp. CG3
Authors: Messaoudi Omar , Steinmann Eike , Praditya Dimas , Bendahou Mourad , Wink Joachim 
Published: August 2022

AbstractExploration of secondary metabolites secreted by new Actinobacteria taxa isolated from unexplored areas, can increase the possibility to obtain new compounds which can be developed into new drugs for the treatment of serious diseases such as hepatitis C. In this context, one actinobacterial strain, CG3, has been selected based on the results of polyphasic characterization, which indicate that it represents a new putative species within the genus Nocardiopsis. Two fractions (F2 and F3), prepared from the culture of strain CG3 in soybean medium, exhibited a pronounced antiviral activity against the HCV strain Luc-Jc1. LC–HRESIMS analysis showed different bioactive compounds in both active fractions (F2 and F3), including five polyenic macrolactams (kenalactams A-E), three isoflavone metabolites, along with mitomycin C and one p-phenyl derivative. Furthermore, feeding with 1% of methionine, lysine or alanine as a unique nitrogen source, induced the production of three novel kenalactam derivatives.
Ophthalmologische Arzneitherapie bei Profisportlern – Was ist erlaubt, was Doping?
Authors: Wall Katharina , Rokohl Alexander C. , Scheiff Anja B. , Katlun Thomas , Heindl Ludwig M. 
Published: August 2022

ZusammenfassungOphthalmologische Medikamente stehen auf den ersten Blick nicht unbedingt im Verdacht, als leistungsfördernde Mittel im Leistungssport angewandt zu werden. Es gibt jedoch einige Beschränkungen, die vor allem bei oraler Einnahme bestimmter Medikamente zu beachten sind. Unter Einbeziehung der aktuellen Maßgaben der Nationalen Anti Doping Agentur Deutschland und der World Anti-Doping Agency wurde eine strukturierte Analyse der Dopingrelevanz ophthalmologischer Medikamente auf Basis einer Literaturrecherche durchgeführt. Eine Anwendung der häufigsten ophthalmologischen Wirkstoffgruppen ist ohne Einschränkungen möglich, vor allem bei topischer Applikation. Eine Ausnahme bildet die orale Einnahme von Diuretika, die jederzeit verboten ist. Bei Glukokortikoiden ist beispielsweise die topische Applikation am Auge erlaubt, jedoch eine orale Applikation innerhalb von Wettkämpfen untersagt. Eine ähnliche Beschränkung gilt bei der Anwendung von Epinephrin, bei der alle systemischen Applikationsformen innerhalb von Wettkämpfen untersagt sind. Bei der Anwendung von Betablockern ist die ausgeübte Sportart maßgeblich, da beim Billard, Bogenschießen, Darts, Golf, Motorsport, Schießsportarten, Skifahren/Snowboarding, Skispringen, Freistil Aerials/Halfpipe und Snowboard Halfpipe/Big Air und Tauchen eine lokale und systemische Anwendung innerhalb von Wettkämpfen unzulässig ist. Beim Schießen und Bogenschießen ist der Gebrauch von Betablockern auch außerhalb von Wettkämpfen untersagt. Sportler*innen mit ophthalmologischen Vorerkrankungen sollten sich vor Anwendung von Medikamenten umfassend von einem Facharzt für Augenheilkunde beraten lassen und gemeinsam einen zulässigen Wirkstoff auswählen, die geeignete Applikationsart beachten und gegebenenfalls, bei obligater Einnahme, einen Antrag auf eine Medizinische Ausnahmegenehmigung stellen. Aktuell ist nicht bekannt wie viele der nationalen und internationalen Sportler*Innen mit Augentropfen behandelt werden müssen.
Role of cochlear reserve in adults with cochlear implants following post-lingual hearing loss
Authors: Thangavelu Kruthika , Nitzge Markus , Weiß Rainer M. , Mueller-Mazzotta Jochen , Stuck Boris A. , Reimann Katrin 
Published: August 2022

Abstract
Introduction
Pre-operative assessments before cochlear implantation (CI) includes the examination of both tone hearing, and the level of the cochlear reserve indicated by speech understanding. The goal of this study was to explore the predictive influence of tone hearing and cochlear reserve in CI.

Methods
We did a retrospective cohort study, which included adult patients who had undergone CI between January 2012 and December 2019 in a tertiary care center. The pre-operative tone hearing, unaided maximum monosyllabic word recognition score (WRSmax), aided hearing gain, aided monosyllabic word recognition score at 65 dB (WRS65(HA)), and speech perception gap (SPG) were measured. The duration of unaided hearing loss (UHL) was also assessed. These variables were compared with post-operative monosyllabic word recognition score after CI at 65 dB (WRS65(CI)).

Results
103 patients and 128 ears were included in this study. Regardless of tone hearing, patients with better pre-operative WRSmax and WRS65(HA) performed better post-operatively. WRSmax was found to be the most important factor that was statistically significantly associated with WRS65(CI). SPG was statistically significantly associated with WRSmax and SPG ≥ 20% group performed better post-operatively. Any duration of unaided hearing loss was statistically significantly inversely associated with WRSmax above 0%.

Conclusion
Cochlear reserve represented by WRSmax may play the most important role as a predictive factor in outcomes after CI. SPG should be considered for indicating CI in patients, when WRS65(HA) does not reach WRSmax. Early rehabilitation with hearing aids and duration of hearing aid usage might play an important role in preserving cochlear reserve in adults.
Evaluation of five methods to identify composite restorations in human teeth on a forensic purpose—an ex vivo comparative study
Authors: Auderset Florence C. , Connert Thomas , Meller Christian , Filippi Andreas , Dagassan-Berndt Dorothea C. 
Published: August 2022

Abstract The use of tooth-colored composite resin materials in dentistry is increasing. As composite restorations appear similar to the natural tooth structure, their detection is becoming more challenging. The aim of this study was to compare five diagnostic methods for detection of dental restorations and to create reliable postmortem dental records for forensic purposes. A conventional examination method without a direct light source (CONV), with a dental loupe light (DL), Galilean loupes with a direct light source (GDL), a fluorescence-inducing device (FIT), and intraoral radiographs (RX) were compared. Dentists specializing in conservative dentistry or oral surgery and dentistry students participated. Regarding sensitivity, specificity, positive predictive value, and negative predictive value, FIT and RX showed significantly higher results than CONV, DL, and GDL. RX and FIT showed comparable results in identifying composite restorations but depending on their location. The combination of both methods may lead to even better results. In conclusion fluorescence-inducing devices show good results in identifying composite restorations and therefore should be considered as a standard tool in forensic examinations. Another advantage is their small size, low cost, and mobility. Good illumination and magnification devices are recommended to enhance performance during conventional examinations. Involving dentists specialized in conservative dentistry could contribute to dental identification.