bluuebunny/crossref_metadata_2025_split huggingface dataset:
Characteristics and Predictors of Sleep Among Spousal Care Dyads Living With Chronic Conditions
Authors: Liu Yin , Song Yeonsu , Johnson Florence U , Lei Lianlian , Choi Seung-won Emily , Antonucci Toni C , Robinson-Lane Sheria G 
Published: September 2022

AbstractObjectivesPoor sleep is common among older adults with chronic health conditions and their spousal caregivers. However, dyadic sleep patterns among spouses are underexplored within the literature. This study examines dyadic sleep characteristics and associated contextual factors among spousal care dyads.MethodsParticipants included 462 older adult spousal care dyads from the 2015 National Health and Aging Trends Study and National Study of Caregiving (mean ages of care recipients/caregivers = 79 and 76 years, respectively; 22% of dyads were living with dementia). Self-reported sleep included frequency of (a) trouble falling back asleep among dyads, (b) care-related sleep disturbances among caregivers, and (c) trouble initiating sleep among care recipients. Predictors included between-dyad characteristics such as whether respondents had dementia, care burden and support, relationship quality, neighborhood cohesion, and within-dyad characteristics such as demographics, depression, and positive affect. We conducted multilevel dyadic analysis and actor–partner interdependence modeling.ResultsSleep was correlated more among dyads living with dementia than those with other chronic conditions. Care dyads had poorer sleep if caregivers reported higher care burden; however, better relationship quality marginally ameliorated the association. Depressive symptoms had a partner effect on poorer sleep among care dyads, whereas positive emotions and older age only had an actor effect on better sleep for care recipients and spousal caregivers. Neighborhood cohesion, care support, and other demographic characteristics were not associated with dyadic sleep outcomes.DiscussionAddressing both care recipient- and caregiver-related factors may improve sleep health for both members of the care dyad living with chronic conditions.
A novel recessive mutation in OXR1 is identified in patient with hearing loss recapitulated by the knockdown zebrafish
Authors: Li Yuan , Ning Guozhu , Kang Baoling , Zhu Jinwen , Wang Xiao-Yang , Wang Qiang , Cai Tao 
Published: September 2022

Abstract
Hereditary hearing loss is a highly genetically heterogeneous disorder. More than 150 genes have been identified to link to human non-syndromic hearing impairment. To identify genetic mutations and underlying molecular mechanisms in affected individuals and families with congenital hearing loss, we recruited a cohort of 389 affected individuals in 354 families for whole-exome sequencing analysis. In this study, we report a novel homozygous missense variant (c.233A &gt; G, p.Lys78Arg) in the OXR1 gene, which was identified in a 4-year-old girl with sensorineural hearing loss. OXR1 encodes Oxidation Resistance 1 and is evolutionarily conserved from zebrafish to human. We found that the ortholog oxr1b gene is expressed in the statoacoustic ganglion (SAG, a sensory ganglion of ear) and posterior lateral line ganglion (pLL) in zebrafish. Knockdown of oxr1b in zebrafish resulted in a significant developmental defect of SAG and pLL. This phenotype can be rescued by co-injection of wild-type human OXR1 mRNAs, but not mutant OXR1 (c.233A &gt; G) mRNAs. OXR1-associated pathway analysis revealed that mutations of TBC1D24, a TLDc-domain-containing homolog gene of OXR1, have previously been identified in patients with hearing loss. Interestingly, mutations or knockout of OXR1 interacting molecules such as ATP6V1B1 and ESR1 are also associated with hearing loss in patients or animal models, hinting an important role of OXR1 and associated partners in cochlear development and hearing function.
Standards in semen examination: publishing reproducible and reliable data based on high-quality methodology
Authors: Björndahl Lars , Barratt Christopher L R , Mortimer David , Agarwal Ashok , Aitken Robert J , Alvarez Juan G , Aneck-Hahn Natalie , Arver Stefan , Baldi Elisabetta , Bassas Lluís , Boitrelle Florence , Bornman Riana , Carrell Douglas T , Castilla José A , Cerezo Parra Gerardo , Check Jerome H , Cuasnicu Patricia S , Darney Sally Perreault , de Jager Christiaan , De Jonge Christopher J , Drevet Joël R , Drobnis Erma Z , Du Plessis Stefan S , Eisenberg Michael L , Esteves Sandro C , Evgeni Evangelini A , Ferlin Alberto , Garrido Nicolas , Giwercman Aleksander , Goovaerts Ilse G F , Haugen Trine B , Henkel Ralf , Henningsohn Lars , Hofmann Marie-Claude , Hotaling James M , Jedrzejczak Piotr , Jouannet Pierre , Jørgensen Niels , Kirkman Brown Jackson C , Krausz Csilla , Kurpisz Maciej , Kvist Ulrik , Lamb Dolores J , Levine Hagai , Loveland Kate L , McLachlan Robert I , Mahran Ali , Maree Liana , Martins da Silva Sarah , Mbizvo Michael T , Meinhardt Andreas , Menkveld Roelof , Mortimer Sharon T , Moskovtsev Sergey , Muller Charles H , Munuce Maria José , Muratori Monica , Niederberger Craig , O’Flaherty Cristian , Oliva Rafael , Ombelet Willem , Pacey Allan A , Palladino Michael A , Ramasamy Ranjith , Ramos Liliana , Rives Nathalie , Roldan Eduardo Rs , Rothmann Susan , Sakkas Denny , Salonia Andrea , Sánchez-Pozo Maria Cristina , Sapiro Rosanna , Schlatt Stefan , Schlegel Peter N , Schuppe Hans-Christian , Shah Rupin , Skakkebæk Niels E , Teerds Katja , Toskin Igor , Tournaye Herman , Turek Paul J , van der Horst Gerhard , Vazquez-Levin Monica , Wang Christina , Wetzels Alex , Zeginiadou Theodosia , Zini Armand 
Published: September 2022

Abstract
Biomedical science is rapidly developing in terms of more transparency, openness and reproducibility of scientific publications. This is even more important for all studies that are based on results from basic semen examination. Recently two concordant documents have been published: the 6th edition of the WHO Laboratory Manual for the Examination and Processing of Human Semen, and the International Standard ISO 23162:2021. With these tools, we propose that authors should be instructed to follow these laboratory methods in order to publish studies in peer-reviewed journals, preferable by using a checklist as suggested in an Appendix to this article.
Performance evaluation of the photovoltaic thermal system with a fin array and surface zigzag layout
Authors: Ghanim Marrwa S , Farhan Ammar A 
Published: September 2022

Abstract
Solar photovoltaic (PV) has many environmental benefits and it is considered to be a practical alternative to traditional energy generation. The electrical conversion efficiency of such systems is inherently limited due to the relatively high thermal resistance of the PV components. An approach for intensifying electrical and thermal production of air-type photovoltaic thermal (PVT) systems via applying a combination of fins and surface zigzags was proposed in this paper. This research study aims to apply three performance enhancers: case B, including internal fins; case C, back surface zigzags; and case D, combinations of fins and surface zigzags; whereas the baseline smooth duct represents case A. A 2D, steady-state simulation model that took into account the impact of the convective flow of air circulating inside the PVT system in addition to radiative and convective heat losses from the front PV surface was developed and validated via previous tests. The results revealed that, under the same volume requirements, the application of surface zigzags is preferred for airflow rates of 0.06 kg/s or less, whereas the introduction of fins is preferred for higher airflow rates. The results also revealed that, of the three cases considered, the introduction of the fin–surface zigzag combination is the most effective and has the potential to improve the electrical and thermal efficiency by ~26% and 3%, respectively.
Unique Equilibrium States for Geodesic Flows on Flat Surfaces with Singularities
Authors: Call Benjamin , Constantine David , Erchenko Alena , Sawyer Noelle , Work Grace 
Published: September 2022

Abstract
Consider a compact surface of genus $\geq 2$ equipped with a metric that is flat everywhere except at finitely many cone points with angles greater than $2\pi $. Following the technique in the work of Burns, Climenhaga, Fisher, and Thompson, we prove that sufficiently regular potential functions have unique equilibrium states if the singular set does not support the full pressure. Moreover, we show that the pressure gap holds for any potential that is locally constant on a neighborhood of the singular set. Finally, we establish that the corresponding equilibrium states have the $K$-property and closed regular geodesics equidistribute.
Why Costly Rivalry Disputes Persist: A Paired Conjoint Experiment in Japan and South Korea
Authors: Lim Sijeong , Tanaka Seiki 
Published: September 2022

Abstract
The literature suggests that voters have a self-centered incentive to call for the de-escalation of conflicts that inflict economic costs on them, which explains why economic sanctions and trade wars often lose popular support when the resulting cost for the domestic economy rises. It is thus puzzling why some costly disputes between two advanced democracies are prolonged. Taking a psychological approach, we argue that nonviolent yet costly disputes between international rivals can fail to de-escalate because the perception of loss invokes anger and risk-taking attitudes. We test our argument using a paired conjoint experiment involving Japan and South Korea. We find that, in both countries, the public becomes more defiant and less supportive of de-escalating an ongoing dispute when informed about (1) the high cost of the trade restrictions on domestic firms, (2) international (i.e., World Trade Organization) support for the rival country, and (3) the rival public's hardline stance on the dispute. These findings lend support to our psychological explanation.
Comparative Chemometric Manipulations of UV-Spectrophotometric Data for the Efficient Resolution and Determination of Overlapping Signals of Cyclizine and Its Impurities in Its Pharmaceutical Preparations
Authors: Fares Michel Y , Abdelwahab Nada S , Hegazy Maha A , Abdelrahman Maha M , El-Sayed Ghada M 
Published: September 2022

Abstract

Background
Cyclizine (CYZ), a commonly used antiemetic drug, has two pharmacopeial toxic impurities, 1-methylpiperazine (MPZ) and diphenylmethanol (DPM). When CYZ parenteral formulations are administered intravenously, both impurities are poisonous, toxic, and harmful to the human body.

Objective
Cyclizine was determined along with its hazardous impurities MPZ and DPM by green multivariate calibration using UV-spectroscopic data.

Methods
Three multivariate algorithms were used to resolve and quantify overlapped spectral signals: principal component regression (PCR), partial least squares (PLS), and synergistic intervals partial least squares (siPLS). A concentration set containing 16 distinct combinations of CYZ, MPZ, and DPM was randomly prepared, and the absorbance values of the concentration set were determined using the 376 point-wavelength set with an interval of 0.2 nm between 200 and 275 nm.

Results
Good linear correlations were established for CYZ, MPZ, and DPM in the concentration ranges of 5.00–25.0, 0.50–2.50, and 0.50–2.50 µg/mL, respectively. The ideal spectral range and associated combinations were chosen based on the lowest root mean error of prediction (RMSEP) and correlation coefficient values (r). The siPLS approach performed better than the PCR and PLS models. The combination of four subintervals, 1, 3, 4, and 7, demonstrated the greatest effect, with RMSEP values of 0.0272, 0.0053, and 0.0315 for CYZ, MPZ, and DPM, respectively, and correlation coefficients of 0.9991, 0.9999, and 0.9997, in order. Various assessment tools were used to evaluate and measure the greenness profile of the established methods. The proposed methods were validated using internal and external validation sets.

Conclusions
The three methods were effectively used to determine CYZ in its pure form and parenteral formulations, as well as its toxic impurities. The acquired results were compared statistically to those obtained using the reported HPLC method.

Highlights
Cyclizine and its toxic impurities can be determined spectrophotometrically by using the three developed chemometric models.
Fertility Treatments and Breast Cancer: A Significant Risk for Our Patients?
Authors: Furlong Samantha A , Sauerbrun-Cutler May-Tal , Dibble Elizabeth H , Carpentier Bianca 
Published: September 2022

Abstract
Fertility medications have been postulated to increase the risk of breast cancer because of the transient but substantial elevation in hormones occurring with their use. Multiple studies exploring the relationship between fertility medications and risk of breast cancer are limited by the wide variety of fertility treatment regimens and confounded by infertility as an independent risk factor for breast cancer. The Practice Committee Guidelines of the American Society of Reproductive Medicine acknowledge that although this relationship is complex, no additional risk of breast cancer has been consistently linked to infertility medications. This article reviews the major studies both supporting and refuting this statement and makes recommendations regarding risk counseling and breast cancer screening in patients with a history of fertility treatments and infertility.
Conceptualizing and Explaining Flexibility in Administrative Crisis Management: A Cross-district Analysis in Germany
Authors: Lenz Alexa , Eckhard Steffen 
Published: September 2022

AbstractFlexibility in administrative crisis management is a frequently reported determinant for a successful crisis response. But there is little agreement about how to conceptualize, measure, and explain flexibility. We use a three-dimensional measure of administrative flexibility, capturing employees’ decision leeway, staff mobility, and organizational innovation in a crisis response. We then develop and test an explanation of variation in flexibility, focusing on the refugee crisis of 2015/16 in Germany and analyzing survey and socioeconomic data from 235 districts using linear regression analysis. The main finding is that differences in flexibility cannot be explained by the scope of the crisis in a district, but by organizational factors: Agencies with politically unconstrained leadership, with higher financial resources and more crisis-related experience, respond more flexible. These findings contribute to theorizing and explaining administrative flexibility in and beyond crisis management and have practical implications for crisis learning and preparation.
Historical Perspective of Pediatric Health Disparities in Infectious Diseases: Centuries in the Making
Authors: Kronman Matthew P , Snowden Jessica N 
Published: September 2022

Abstract
Coronavirus (COVID-19) laid bare the disproportionate effects of infectious agents on vulnerable communities. However, historically, infectious diseases have long been known to affect certain communities to a greater extent than others. The mechanisms behind these differences are multifactorial, and lie less in biological susceptibility and instead more on socioeconomic factors and other social determinants of health. This article highlights health disparities in common infections such as respiratory syncytial virus, tuberculosis, HIV, syphilis, and influenza and will use lessons learned from previous pathogens and infectious disease disparities in vulnerable populations to provide context to the COVID-19 pandemic.
Prediction of proton beam range in phantom with metals based on monochromatic energy CT images
Authors: Meng Qianqian , Li Jing , Jiang Wei , Hu Birong , Xu Feng , Shi Xiaomeng , Zhong Renming 
Published: September 2022

Abstract
The purpose of the study was to evaluate the accuracy of monochromatic energy (MonoE) computed tomography (CT) images reconstructed by spectral CT in predicting the stopping power ratio $( SP{R}_w)$ of materials in the presence of metal. The CIRS062 phantom was scanned three times using spectral CT. In the first scan, a solid water insert was placed at the center of the phantom $(C{T}_{no\ metal})$. In the second scan, the solid water insert was replaced with a titanium alloy femoral head $(C{T}_{metal})$. The metal artifact reduction (MAR) algorithm was used in the last scan $(C{T}_{metal+ MAR})$. The MonoE-CT images of 40 keV and 80 keV were reconstructed. Finally, the single-energy CT method (SECT) and the dual-energy CT method (DECT) were used to calculate the $SP{R}_w$. The mean absolute error (MAE) of the $SP{R}_w$ of the inner layer inserts calculated by the SECT method were 3.19%, 13.88% and 2.71%, corresponding to $C{T}_{no\ metal}$, $C{T}_{metal}$ and $C{T}_{metal+ MAR}$, respectively. For the outer layer inserts, the MAE of $SP{R}_w$ were 3.43%, 5.42% and 2.99%, respectively. Using the DECT method, the MAE of the $SP{R}_w$ of the inner layer inserts was 1.30%, 3.69% and 1.46% and the MAE of the outer layer inserts– was 1.34%, 1.36% and 1.05%. The studies shows that, compared with the SECT method, the accuracy of the DECT method in predicting the $SP{R}_w$ of a material is more robust to the presence of metal. Using the MAR algorithm when performing CT scans can further improve the accuracy of predicting the SPR of materials in the presence of metal.
Immediate Accidents and Lingering Trauma: Railwaymen Poets, Danger, and Emotive Verse
Authors: Betts Oliver 
Published: September 2022

Abstract
This paper examines the work of a group of Railwaymen Poets, whose verse has been collected as part of the Piston, Pen and Press project. It explores their writings both as part of an emerging theme of accident and loss poetry surrounding the railways in Victorian culture but also more specifically as interrelated texts produced by workers sharing common experiences. Whilst many wrote about all manner of subjects, not just the railway accident, public fascination with accident reporting allowed them to both pursue their literary endeavours and also to use poetry as a form of catharsis. Their poetry, this paper argues, should be read as a collective expression of emotion around the dangerous and loss-ridden nature of their work.
Probing the Galactic halo with RR lyrae stars − III. The chemical and kinematic properties of the stellar halo
Authors: Liu Gaochao , Huang Yang , Bird Sarah Ann , Zhang Huawei , Wang Fei , Tian Haijun 
Published: September 2022

ABSTRACT
Based on a large spectroscopic sample of ∼4300 RR Lyrae stars with metallicity, systemic radial velocity, and distance measurements, we present a detailed analysis of the chemical and kinematic properties of the Galactic halo. Using this sample, the metallicity distribution function (MDF) as a function of r and the velocity anisotropy parameter β profiles (for different metallicity populations) are derived for the stellar halo. Both the chemical and kinematic results suggest that the Galactic halo is composed of two distinct parts, the inner halo and outer halo. The cutoff radius (∼30 kpc) is similar to the previous break radius found in the density distribution of the stellar halo. We find that the inner part is dominated by a metal-rich population with extremely radial anisotropy (β ∼ 0.9). These features are in accordance with those of ‘Gaia-Enceladus-Sausage’ (GES) and we attribute this inner halo component as being dominantly composed of stars deposited from this ancient merged satellite. We find that GES probably has a slightly negative metallicity gradient. The metal-poor populations in the inner halo are characterized as a long tail in MDF with an anisotropy of β ∼ 0.5, which is similar to that of the outer part. The MDF for the outer halo is very broad with several weak peaks and the value of β is around 0.5 for all metallicities.
Lepton masses and mixings, and muon anomalous magnetic moment in an extended B − L model with the type-I seesaw mechanism
Authors: Vien V V , Long Hoang Ngoc , Hernández A E Cárcamo 
Published: September 2022

Abstract
We propose a B − L model combined with the S4 × Z3 × Z4 discrete symmetry that successfully explains the recent 3+1 sterile–active neutrino data. The smallness of the neutrino mass is obtained through the type-I seesaw mechanism. The active–active and sterile–active neutrino mixing angles are predicted to be consistent with the recent constraints in which $0.3401\, (0.3402) \le \sin ^2\theta _{12}\le 0.3415\, (0.3416), \, 0.456\, (0.433) \le \sin ^2\theta _{23}\le 0.544\, (0.545), \, 2.00\, (2.018) \le 10^2\times \sin ^2\theta _{13}\le 2.405\, (2.424),\, \, 156 \, (140.8) \le \delta ^{(\circ )}_{CP}\le 172\, (167.2)$ for normal (inverted) ordering of the three-neutrino scenario, and $0.015 \, (0.022) \le s^2_{14}\le 0.045 \, (0.029), \, 0.005 (0.0095)\le s^2_{24}\le 0.012\, (0.012), \, 0.003 \, (0.009)\le s^2_{34} \le 0.011$ for normal (inverted) ordering of the 3+1 neutrino scenario. Our model predicts flavor-conserving leptonic neutral scalar interactions and successfully explains the muon g − 2 anomaly.
The COVID-19 Pandemic: Effects on Pediatric Fracture Patterns in the Emergency Department and Subspecialty Follow-up Care
Authors: Lapsa Julianne , Bukola Badaki Oluwakemi , Xu Amy , Eaton Cyd , Lee R. Jay , Ryan Leticia 
Published: September 2022

Purpose:
The COVID-19 pandemic affected pediatric fracture injury patterns and volume. There is a paucity of research evaluating this trend throughout the pandemic and also follow-up to orthopaedic subspecialty care after emergency fracture management.

Methods:
This retrospective cohort study reviewed patients 2 to 18 years of age presenting for fracture care to an urban pediatric emergency department. We assessed patient demographics, clinical care, and follow-up to surgical subspecialist. Time periods investigated included March 30 to September 4, 2020 (pandemic), March 30 to September 4, 2019, and March 30 to September 4, 2018 (prepandemic). Subanalysis within the pandemic was during the “stay-at-home order” verses the phased re-opening of the state. Descriptive statistical analysis, Pearson’s χ2 or Fisher exact tests, and Mann-Whitney U tests were performed.

Results:
In this population, fractures overall declined by 40% (n=211) during the pandemic compared with 2019 (n=349) and 28% compared with 2018 (n=292). Lower extremity fractures accounted for a greater percentage of injuries during the pandemic compared with prepandemic. Time to surgical subspecialty follow-up was shortest during the 2020 pandemic peak at 9 days and was significantly longer during phased reopening (phase 1: 18 d, P=0.001; phase 2: 14 d, P=0.005). These patterns were also consistent for days to repeat imaging.

Conclusions:
We found differences in fracture prevalence, mechanisms, and follow-up care during the pandemic. Time to subspecialty follow-up care was longer during pandemic phased reopening despite overall fewer fractures. Plans to absorb postponed visits and efficiently engage redeployed staff may be necessary to address difficulties in follow-up orthopaedic management during public health crises.

Level of Evidence:
Level II.