bluuebunny/crossref_metadata_2025_split huggingface dataset:
ФЕНОТИПІЧНІ ОСОБЛИВОСТІ КЛІТИН ІМУННОЇ СИСТЕМИ У ВАГІТНИХ ЖІНОК, ЯКІ МАЛИ БЕЗПЛІДДЯ РІЗНОГО ГЕНЕЗУ В АНАМНЕЗІ
Authors: Коломієць Олена Володимирівна , Туманова Лариса Євгеніївна , Холод Валерія Володимирівна , Величко Марина Борисівна 
Published: September 2022

Вступ. Комплексні клініко-лабораторні дослідження вагітних жінок з вивченням стану їх імунної системи — CD-фенотипу, в тому числі експресією внутрішньоклітинних цитокінів, є актуальними і важливими для розробки тактики спостереження і терапії, особливо у випадках безплідності в анамнезі.
Мета роботи – визначення особливостей рівнів імунокомпетентних клітин крові на основі CD-фенотипа з експресією внутрішньоклітинних цитокінів у вагітних жінок із безпліддям різного генезу в анамнезі.
Матеріали і методи. За допомогою клітинного цитофлуориметра FACSCan (Becton Dickinson, США) і тест-систем Becton Dickinson (США) визначали особливості імунітету з використанням моноклональних антитіл (МКА) до диференційованих антигенів лімфоцитів CD3, CD4, CD8, CD19, CD56, маркерів активації (HLA-DR, CD25, CD69), а також внутрішньоклітинну експресію цитокінів (IFN-γ, TNF-α, IL-4 і IL-10) CD3+CD4+-клітинами, у 436 не вагітних (референтна група n), 280 здорових вагітних без ускладненого анамнезу (група N) та 88 вагітних жінок із безпліддям різного генезу в анамнезі.
Результати. Проведені дослідження імунної системи вагітних жінок із ендокринним (1 гр.), перитонеальним (2 гр.) чи поєднаним (ендокринним і трубнозапальним труб-перитонеальним) (3 гр.) характером безпліддя в анамнезі виявили достовірне підвищення у жінок з хронічними інфекціями (2 гр.), порівняно з нормою у не вагітних, відносних рівнів CD3+ та CD3+CD4+-лімфоцитів з високою експресію у них маркерів активації HLA-DR та CD25, так само як і активації CD3+CD8+-, NK T CD3+CD4+CD56+- та CD3-CD56+-лімфоцитів за експресією ними антигенів гістосумісності ІІ класу. Показано також підвищення в порівнянні з здоровими не вагітними, на відміну від інших двох груп, функціональної активності Т-хелперів по продукції прозапальних цитокінів за даними експресії у них відповідних маркерів (IFN-γ+ та TNF-α+) в групі вагітних жінок з безпліддям запального генезу в анамнезі; експресія протизапальних IL-4 та IL-10 не відрізнялась він норми в усіх 3-х групах. Фенотипічні особливості імунокомпетентних клітин пацієнток із запальним безпліддям в анамнезі, так само як і інших двох груп, не відрізняються від здорових вагітних в ці терміни часу (6-10 тижнів), за винятком зниження рівнів у них CD3+CD4+IL-10+-лімфоцитів, що може бути прогностично небезпечним для зберігання нормального про-/протизапального цитокінового балансу.
Висновки. У обстежених всіх груп з ускладненим анамнезом в 1 триместрі досліджені показники не відрізняються від здорових вагітних на тих самих строках, але у жінок із трубно-перитонеальними запальними гінекологічними захворюваннями в анамнезі більш висока, порівняно з не вагітними, активація Т-кілерів, Т-цитотоксичних, натуральних кілерів і Т-хелперів/індукторів, в тому числі за внутрішньоклітинною секрецією прозапальних цитокінів IFN-γ і TNF-α, з достовірним зниженням — протизапального IL-10 при порівнянні з двома іншими групами.
Quelle évolution pour le Système monétaire international ?
Authors: Artus Patrick , Gravet Isabelle 
Published: September 2022

Est-ce que le dollar va rester la monnaie de réserve dominante, malgré l’endettement excessif des États-Unis, et en l’absence d’un substitut crédible au dollar ? Est-ce que la politique monétaire des États-Unis continuera à privilégier les situations domestiques sans tenir compte des externalités sur les pays émergents ? Est-ce que le financement extérieur des États-Unis va devenir plus difficile ? Ce qui entraînerait une dépréciation du dollar, avec la forte hausse de l’endettement extérieur des États-Unis, la volonté de l’Europe de conserver son épargne pour investir, avec la volonté des pays émergents de limiter les sorties de capitaux. Ou bien allons-nous rentrer dans un nouveau système pour limiter la variabilité déstabilisante des flux internationaux de capitaux : contrôles sélectifs des capitaux, réaction plus forte des politiques monétaires aux taux de change ? Est-ce que le Système monétaire international va continuer à se privatiser avec un rôle accru des flux de capitaux en actions, et donc de l’attractivité des entreprises, par rapport aux flux de capitaux en dettes publiques ? Ce papier tente de répondre à ces différentes questions qui sont cruciales pour l’avenir du système financier international. Classification JEL : E4, E5, E58, F3
Corneal Epithelium Thickness and Refractive Changes After Myopic Laser Corneal Refractive Surgery
Authors: Canto-Cerdan Mario , El Bahrawy Mohamed , Alió Jorge L. , Casanova Laura , García María J. , Al-Amri Saad Abdulrahman J. , Cavas Francisco , Alió del Barrio Jorge L. 
Published: September 2022

PURPOSE:
To evaluate the postoperative changes in corneal epithelium thickness and refractive power after femtosecond laser–assisted laser in situ keratomileusis (LASIK) and small incision lenticule extraction (SMILE) for myopia correction using anterior segment optical coherence tomography (OCT) with an integrated Placido disc topographer.

METHODS:
The VisuMax 500-kHz femtosecond laser (Carl Zeiss Meditec AG) and Amaris 750 excimer laser (SCHWIND eye-tech-solutions) were used. Central, paracentral, and 6-mm epithelial thickness values were obtained, and the change in the value of epithelial thickness was calculated. Changes in the refractive power of the epithelium were also evaluated. The repeatability of this new measurement was also analyzed using the intraclass correlation (ICC). The total follow-up period was 6 months.

RESULTS:

A total of 77 LASIK eyes were matched with 77 SMILE eyes. Mean spherical equivalent was −3.92 ± 1.67 diopters (D) for LASIK versus −4.02 ± 1.63 D for SMILE (
P
= .356). Epithelial thickness parameters significantly and equally thickened in both types of surgery. The change in the value of epithelial thickness was positively correlated with spherical aberration. Analysis of the refractive power of the corneal epithelial layer (ICC > 0.70) showed a tendency for the postoperative myopization of the refractive component of this layer (−0.11 D for SMILE and −0.53 D for LASIK at 3 mm) and an increase in its cylinder and aberrometry. Increasing postoperative spherical aberration and epithelial thickness increased myopization of the epithelial refractive sphere (
P
< .05).

CONCLUSIONS:
Corneal epithelium thickens similarly after LASIK and SMILE, being slightly higher after SMILE. This correlates with the induced spherical aberration. Corneal epithelium thickening induces myopization of its refractive power, which accounts for a slight regression of the net refractive power change on the treated cornea.

[
J Refract Surg
. 2022;38(9):602–608.]
Strengthening Health Literacy of Vulnerable Groups—Introduction of Two New Modules Within the Communal Health Guides Intercultural in Frankfurt am Main Project
Authors: Schade Manuela , Lang Sarah Alexandra , Stenzel Sophia 
Published: September 2022

Health literacy is limited among most of the German population. Among vulnerable groups, including people with a migration history, it is necessary to provide support. Thus, the public health department of the city of Frankfurt am Main initiated a project called communal health guides intercultural [Kommunale Gesundheitslotsen interkulturell] where health guides are trained to strengthen the health literacy of people with a migration background as well as of people with poor socioeconomic living conditions. Health guides are trained on specific health topics to pass on their knowledge as multipliers in different target groups. We are introducing two new modules complementing the existing health guide project from conceptualization to evaluation. The first module aims to strengthen health literacy among parents of children younger than age 10 years and the second module addresses inhabitants of community accommodations and aims to improve health communication and information, currently focusing on coronavirus disease 2019 and vaccinations. Another aim of the two modules is to find out the specific information needs of the target populations. The newly added modules aim to reduce health inequities for all citizens of Frankfurt am Main. [

HLRP: Health Literacy Research and Practice
. 2022;6(3):e239–e246.

]

Plain Language Summary:
Health literacy is often limited among the German population. Especially for socially disadvantaged groups, the public health department of the city of Frankfurt am Main would like to provide support. A project called Communal Health Guides Intercultural was initiated. Health leaders are trained to strengthen the health literacy of people who are socially disadvantaged. This project consists of two modules. One module is aimed at parents of children younger than age 10 years; the other module is aimed at residents in community accommodation. The project aims to reduce health inequities.
Evaluation of the role of Islamic values in improvement of spiritual health among Iraqi Muslims
Authors: Wahyuni W. , Ahmed Shihab Saman , Ghazi Talib Saad , A. Mutlak Dhameer , Abed Hussein Rasha , Ketut Acwin Dwijendra Ngakan 
Published: September 2022

Given that most of the adults’ life is spent in the workplace, and because the quality of working life has a significant effect on family life and community health, it is crucial to study the components involved in the improvement of the workplace and people’s health in the work environment. Therefore, by examining the common literature of Islamic values, spirituality and spiritual health, an attempt has been made in this research to explain organisational values and spiritual health in the management of organisations and to analyse the relationship of these variables with each other in Iraq using an Islamic approach. Similar to any other community, an Islamic community requires management proportional to its specific circumstances. In fact, an Islamic community needs a type of management that intertwines with divine and Islamic values and ethical principles and prioritises Islamic ideals. Therefore, this study aims to evaluate the role of organisational values in the improvement of Islamic values of Iraqi Muslims. To this end, 2800 employees selected from 30 oil and chemical compound manufacturing organisations are examined. According to the results, the Islamic values governing the Iraqi organisations play an effective role in the improvement of employees’ spiritual health.Contribution: Divine and religious values and Islamic ethics have always been considered in Islamic communities, where formal and informal procedures are taken into consideration. An Islamic approach to management is combined with Islamic values, behaviours and ethics, and these values affect Islamic administration. Therefore, a proper understanding of Islamic values will help develop the right plan for human resource management, as well as the maintenance of organisational and community health.
Sovereign responsibility: An impossible solidarity
Authors: Molapo Sepetla 
Published: September 2022

This article takes interest in solidarity as sovereign responsibility. Sovereign responsibility is a nonproductive form of care that emerges at the interface of order defined by a privileging of economy and a general economy defined by a return to order of life lost to death. It is this return that unveils the existence and operations of a general economy that order presupposes. The article locates its discussion of sovereign responsibility at two levels of relationality. Firstly, it situates its deliberations concerning sovereign responsibility in the family and among kin. Here it argues that as a form of solidarity, sovereign responsibility positions relations among kin as those of neighbours. Secondly, it shows that the question of the neighbour extends beyond kinship relations and into the realm of extra-kinship relations where others and strangers appear as neighbours. The overall argument of the article is that sovereign responsibility holds potential to facilitate an Afrocentred and counter-hegemonic response to the modern experience of alienation.Contribution: The modern experience of alienation, as well as how it can be challenged, are of interest to this article. The article recognises that numerous attempts have been made to try and address this problematic of alienation in modernity. What it claims has not been done is to engage that problem by taking Africa as an idea, and not just geography, seriously.
A comprehensive review of Trivanga bhasma (herbomineral trimetallic formulation)
Authors: Jawanjal Pravin , Choudhary Swapnil , Bedarkar Prashant , Patgiri B. J. 
Published: September 2022

BACKGROUND:
Trivanga Bhasma, a herbomineral formulation prepared by incineration of Vanga (Tin), Naga (Lead), Yashada (zinc). In Rasa Kaumudi Trivanga bhasma is mentioned as Triloha bhasma.

AIM:
The aim of the present study was analysis of various pharmaceutical methods, doses, indications, of Trivanga Bhasma mentioned in Ayurveda texts.

INTRODUCTION:
Trivanga Bhasma is indicated in MutraRoga (disorders of urine), Madhumeha (Diabetes) and Vandhyatva (Infertility), Napunasakta (Impotency), Shaktivardhaka (Strength) Swetapradara (Leucorrhea).

METHODS:
Ancient Ayurvedic classics included Rasatantrasara Evam Siddhaprayoga Sangraha, Ayurvedeeya Oushadi Gunadharma Shastra, Siddhayoga Sangraha, Rasa Kaumudi, Bhasma Vigyana, Rasa Raj Mahodadhi, and other available translations in various languages were viewed. Marana (incineration) method of Trivanga Bhasma mentioned in classics were collected and analyzed. A comprehensive review of Trivanga Bhasma has been attempted by searching of published literatures in various database including Web of Science, PubMed, Scopus, Taylor and Francis, Google Scholar, and University Grants Commission care journals list.

DISCUSSION:
In classical texts, fourteen methods of preparation of Trivanga Bhasma were found and in texts-Rasa Kaumudi-1, Rasayansara-2, SiddhaYoga Samgraha-1, Rasaraj Mahodadhi-1, Ayurvediya Aushadhi Guna Dharma Shastra-1, Rasatantra Sara Evam Siddha Prayoga Samgraha-2, Bhasma Vigyana-5, and Ayurvedic Formulary India-1 methods are mentioned. In these methods, 9 methods were Jarana followed by Putapaka, Jarana in 3 methods, Damaru Yantra Kramangi paka in 2 methods.

CONCLUSION:
A total of 14 methods of Marana with 22 media are mentioned for Trivanga Bhasma.
Out-of-pocket expenditure on maternal health care in two backward districts of Karnataka
Authors: Swamy Shivakumar , Lakshmi Jyothi S 
Published: September 2022

BACKGROUND:
Maternal health is an important indicator of a woman's health and society. Safe motherhood is still a nightmare in many communities. Medical services related to maternal health are almost free in India, yet many families face significant out-of-pocket (OOP) expenditure, especially in poor communities in the rural areas, leading to more poverty and exclusion. This study has the aim of revealing OOP expenditure on maternal health care in rural areas.

METHODS:
A community-based cross-sectional study was conducted among 386 randomly selected mothers who had delivered a baby in the past 2 years in two backward districts of Karnataka using a mixed method. Univariate, bivariate, and t-tests were used for the analysis.

RESULTS:
The findings revealed that poor education and low income have a significant association with OOP expenditure. Getting laboratory services, purchasing medicine from the market, informal payments to the hospital staff, and other indirect costs are the major components of catastrophic expenditure for the poor mothers.

CONCLUSION:
It is concluded that there is strong evidence to support the high burden of maternal health-care spending. More comprehensive schemes are needed in the government's maternal health-care services to reduce out-of-pocket expenses.
Comparison of thoracic epidural and ultrasound guided erector spinae plane block in pediatric thoracic surgeries
Authors: Reddy N Vineela , Ghodke Sandhya , Hiremath Ravishekar N , Nimbannavar Smita M , Kulkarni Mahesh Krishna 
Published: September 2022

OBJECTIVE:
The objective of this study was to compare the efficacy of thoracic epidural and ultrasound-guided (USG) erector spinae plane block in pediatric thoracic surgeries.

MATERIALS AND METHODS:
Eight patients undergoing elective thoracic surgeries – videoscopic-assisted thoracic surgeries were divided into two groups, Group A – who received single-shot thoracic epidural using 0.125% bupivacaine in a dose of 0.5 ml/kg and Group B – who received USG erector spinae block (ESP block) using 0.125% bupivacaine in a dose of 0.5 ml/kg. Postprocedure visual analog scale (VAS) score was used to assess pain for the first 24 h. Pain assessment was done 6th hourly. Time of the first requirement of analgesics was noted and injection paracetamol 15 mg/kg intravenously was given as rescue analgesic.

RESULTS:
In Group A, VAS scores were higher compared to Group B. The duration of analgesia with single-shot epidural lasted for about 4–6 h postoperative whereas that with ESP block lasted for 8 or 10 h postoperatively. The time of the first requirement of analgesics was earlier in Group A compared to Group B.

CONCLUSION:
USG ESP block provides better analgesia compared to thoracic epidural.
Pulmonary function tests, fatigue levels and functional capacity in head and neck cancer patients undergoing cancer therapy
Authors: Pattanshetty Renu , Huddar Varsha , Kharwandikar Prasad 
Published: September 2022

BACKGROUND:
The changes in pulmonary functions and fatigue; occurring in the months and years following cancer therapy have been well documented. The changes that occur in the hours of the cancer treatment are less clear.

AIMS AND OBJECTIVES:
The changes detected in the early stage of cancer treatment may help to prevent late pulmonary & associated complications.

MATERIALS AND METHODS:
The pre and post scores were taken after 3 days of treatment. PFT was recorded by vitalograph & peak flow meter, fatigue levels were assessed by FACIT-F scale and functional capacity was assessed by distance covered in 6- minute walk test.

RESULTS:
One hundred and seventeen patients with head and neck cancer were recruited 108 were males and 09 females with mean age of 52.2 years; there is a significant statistical reliable difference between the pre & post treatment values, with P-value is 0.001< 0.05. It justifies the deuteriations in health outcome post intervention.

CONCLUSION:
There is significant deterioration seen in the PFT, fatigue levels, functional capacity; could cause significant clinical problems. Early detection of all these changes can helps the patients as well as therapist to avoid or minimal late complications.
Comparison of demographic, socioeconomic, and lifestyle determinants in infertile and fertile males and females from two big cities of Punjab
Authors: Kaur Simranpreet , Thaman Richa G. , Sood Reena , Sambyal Vasudha , Sandhu IMS , Beri Archana , Chawla MS 
Published: September 2022

BACKGROUND:
Infertility is an apparent failure of a couple to conceive. The demographic, socioeconomic, and lifestyle determinants in infertility and its related factors should be seen more realistically. Regional variations in the causes of infertility need a completely comprehensive approach that helps to dive deeper into the root cause of the disease and manage it holistically.

MATERIALS AND METHODS:
A study on selected risk factors of infertility among 100 infertile couples and 200 fertile males, females attending tertiary health-care centers and in vitro fertilization centers from two big cities of Punjab was conducted. The data were collected using semi-structured pro forma questionnaire. The data collected included the anthropometric measurements, demographic profile, lifestyle variables impacting infertility, and socioeconomic attributes. Data were analyzed to look out for risk factors and their association using the odds ratio.

RESULTS:
The findings of the study revealed that nonvegetarian diet, more tea and alcohol usage, smoking abuse, and duration of mobile phone usage were seen more in infertile couples which was statistically significant in relation to fertile participants. Occupation, physical activity, sleep, socioeconomic variables, and education status did not show any statistical significance when compared between the two groups. Interestingly, statistical significance was seen in the obese class II category only in infertile males in comparison to fertile males.

CONCLUSION:
An all-inclusive perspective is needed for the diagnosis, treatment, and management of infertility. Health-care professionals need to dive into aspects of infertility treatment other than medical interventions to provide an integrated treatment regimen for couples facing infertility.
Unusual histomorphological spectrum of urinary bladder cancers and their treatment modalities revisited: Our experience with series of five cases
Authors: Mohanty Pranita , Mohapatra Ajit S. , Sabat Debabrat , Nayak Jhasaketan 
Published: September 2022

ABSTRACT

Background:
Urinary bladder cancer is the eighth-most frequent carcinoma in men, commonly occurs in elderly male. Major risk factors are smoking, chronic cystitis, urinary stones. The most common histologic variant of bladder cancer is urothelial carcinoma (UC), but certain variants are unusual yet aggressive for which there is no consensus guideline of therapy. Those entities include neuroendocrine tumors both primary and metastatic, squamous cell carcinoma, and sarcomatoid carcinoma. Neuroendocrine tumors comprise carcinoid, small-cell carcinoma, and large-cell carcinoma.

Aim:
The present study is undertaken to highlight certain biological features of these unusual aggressive histological forms of bladder carcinoma and their recent treatment modality to prevent recurrence, metastasis, upgrading of tumor stage, and enable surprisingly complete remission.

Methods:
This piece of hospital-based perspective study was done from June 2018 to May 2020. Both transurethral resection of bladder tumor and cystectomy surgical samples of the symptomatic patients were collected from the urology department of our institute along with demographic data. Then processed, stained in both routine H and E stain and immunohistochemical stains (Immunohistochemistry [IHC]) like PanCK, NSE, synaptophysin, chromogranin, etc.

Results:
Total number of bladder cancer encountered was 42 cases; of these five rare variants were observed, i.e., one case each of primary and secondary small cell neuroendocrine carcinoma, one large cell carcinoma, one squamous cell carcinoma (SCC), and one case of sarcomatoid carcinoma. Histomorphology with IHC conferred the diagnosis then multimodality therapy (neoadjuvant/radiotherapy/surgery) was installed and followed up.

Conclusion:
The unconventional forms of UC can be easily diagnosed by histomorphology and can have better survival with the help of the recent multimodal treatment approach.
Gastric outlet obstruction as an unusual presentation of metastatic breast carcinoma
Authors: Misra Sunayana , Mudgal Priyadarshna , Ahuja Arvind 
Published: September 2022

ABSTRACT
Gastrointestinal (GI) metastasis from breast carcinoma is a rare occurrence. If metastasis occurs to the stomach/duodenum, it can present with symptoms of gastric outlet obstruction (GOO). Hence, it clinically mimics a variety of benign as well as malignant causes of GOO, including primary malignancy. GI metastasis from breast carcinoma occurs several years after the primary diagnosis and sometimes may be the first presenting symptom. If clinical records are not available, it may be misdiagnosed as poorly differentiated adenocarcinoma on biopsy. A high index of suspicion, subtle histologic clues, and appropriate immunohistochemistry helps in clinching the right diagnosis. Hereby, we report the case of a 55-year-old female who presented with metastasis to the duodenum 8 years post mastectomy which mimicked a primary ampullary/periampullary tumor.