bluuebunny/crossref_metadata_2025_split huggingface dataset:
Management of patients with aphthous-like ulcers related to aplastic anaemia in the COVID-19 pandemic era through teledentistry: A case report
Authors: Talahatu Lani Berlina , Kaban Bima Ewando , Ayuningtyas Nurina Febriyanti , Brilyanti Intan Noha , Parmadiati Adiastuti Endah , Radithia Desiana , Pratiwi Aulya Setyo 
Published: March 2022

Background: Aplastic anaemia is a disease that occurs when the body fails to produce enough blood cells. Oral lesions, such as canker sores, are often used as an early marker of this disease condition. In the COVID-19 pandemic era, a teledentistry method is expected to assist in the management of patients with various diseases including aplastic anaemia. Purpose: This case report discusses the management of patients with aphthous-like ulcers related to aplastic anaemia in a 34-year-old woman, based on history, clinical examination, and blood tests through teledentistry. Case: The patient complained of a bleeding wound on the inner left cheek and corner of the left lip that appeared one month ago. There was an ulcer lesion that was bleeding easily in the buccal mucosa sinistra and the angular sinistra, as well as macules lesion on her hand and foot. The complete blood count test exhibits a low platelet level. Case management: The diagnosis was an aphthous-like ulcer related to aplastic anaemia. Patient was treated with topical antiseptic and anti-inflammatory mouthwashes for the oral lesions, as well as collaboration with the medical team. The lesions improved after the patient received a blood transfusion and drug therapy from the internist while she was hospitalized, but the lesions reappeared in other locations in the oral cavity when the platelet level dropped. Conclusion: Management of oral manifestations in patients with aphthous-like ulcers related to aplastic anaemia in the COVID-19 pandemic era can be done through teledentistry. However, this requires sensitivity from the dentist, patient compliance in following instructions, and the involvement of a multidisciplinary approach, such as collaboration with internists to achieve recovery. Delay in detecting and treating aplastic anaemia will lead to death, as in this case.
LITERATURE STUDY OF WORK ACCOMPANIMENT MUSIC EFFECT ON EMPLOYEE PRODUCTIVITY IN SEVERAL COMPANIES
Authors: Lisa Sofia Nuria , Dwiyanti Endang 
Published: March 2022

ABSTRACTIncreased employee productivity can provide benefits for the company. However, isntability of employee productivity can cause some companies to find losses. Accompaniment music at work can be used as a solution to increase employee productivity. This study aims to determine the effect of accompaniment music at work on employee productivity in few companies. This study used a literature study method by reviewing 16 articles obtained from Google Scholar. The criteria for the articles used in this study discussed topics related to accompaniment music at work and employee productivity in several companies at least the last 10 years. Some data that have been collected will be analyzed using a description analysis flow. The results of the study showed that accompaniment music at work has a significant effect on employee productivity in several companies, that productivity was influenced by work environment factors, work spirit, cooperation, work loyalty, work speed, work stress, workload, fatigue, comfort, education level, age, work experience, gender, training, mental, and physical abilities of employees, as well as the relationship between superiors and subordinates. The form of increased employee productivity after accompaniment music while working are work being completed quickly and the results of the product or goods produced exceeding the target. ABSTRAK Meningkatnya produktivitas karyawan dapat memberikan keuntungan bagi perusahaan. Namun karena produktivitas karyawan yang cenderung tidak stabil, menyebabkan beberapa perusahaan mengalami kerugian. Musik pengiring kerja dapat dijadikan sebagai salah satu solusi untuk meningkatkan produktivitas karyawan. Penelitian ini bertujuan untuk mengetahui pengaruh musik pengiring kerja terhadap produktivitas karyawan di beberapa perusahaan. Metode penelitian yang digunakan dalam penelitian ini adalah metode studi literatur dengan mengkaji sebanyak 16 artikel yang didapatkan dari google scholar. Kriteria artikel yang digunakan adalah artikel yang membahas mengenai topik yang berhubungan dengan musik pengiring kerja dan produktivitas karyawan di beberapa perusahaan pada 10 tahun terakhir. Beberapa data yang dikumpulkan akan dianalisis menggunakan alur analisis deskripsi. Hasil pengkajian menunjukkan bahwa musik pengiring kerja berpengaruh secara signifikan terhadap produktivitas karyawan di beberapa perusahaan, dimana produktivitas ini dipengaruhi oleh faktor lingkungan kerja, semangat kerja, kerjasama, loyalitas kerja, kecepatan kerja, stress kerja, beban kerja, kelelahan, kenyamanan, tingkat pendidikan, usia, pengalaman kerja, jenis kelamin, pelatihan, mental dan kemampuan fisik karyawan, serta hubungan antara atasan dan bawahan. Produktivitas karyawan dapat meningkat setelah diberi perlakuan mendengarkan musik berupa pekerjaan menjadi cepat selesai dan hasil produk atau barang yang dihasilkan melebihi target.
A Bayesian Framework for Addressing the Uncertainty in Production Forecasts of Tight-Oil Reservoirs Using a Physics-Based Two-Phase Flow Model
Authors: Ruiz Maraggi L. M. , Lake L. W. , Walsh M. P. 
Published: March 2022

Summary
Extrapolation of history matched single-phase flow solutions is a common practice to forecast production from tight-oil reservoirs. Nonetheless, this approach (a) omits multiphase flow effects that exist below bubblepoint conditions and (b) has not included the quantification of the uncertainty of the estimated ultimate recovery (EUR). This work combines a new two-phase (oil and gas) flow solution within a Bayesian framework to address the uncertainty in the EUR. We illustrate the application of the procedure to tight-oil wells of west Texas.
First, we combine the oil and the gas flow equations into a single dimensionless two-phase flow equation. The solution is a dimensionless flow rate model that can be easily scaled using two parameters: hydrocarbon pore volume and characteristic time. Second, this study generates the probabilistic production forecasts using a Bayesian approach in which the parameters of the model are treated as random variables. We construct parallel Markov chains of the parameters using an adaptative Metropolis-Hastings (M-H) Markov chain Monte Carlo (MCMC) for this purpose. Third, we evaluate the robustness of our inferences using posterior predictive checks (PPCs). Finally, we quantify the uncertainty in the EUR percentiles using the bootstrap method.
The results of this research are as follows. First, this work shows that EUR estimates based on single-phase flow solutions will consistently underestimate the ultimate oil recovery factors in solution-gas drives where the reservoir pressure is less than the bubblepoint. The degree of underestimation will depend on the reservoir and flowing conditions as well as the fluid properties. Second, the application of parallel Markov chains using an adaptative M-H MCMC scheme that addresses the correlation between the model’s parameters solves the issues of mixing and autocorrelation of Markov chains and, thus, it speeds up speeding up the convergence of the Markov chains. Third, we generate replicated data from our posterior distributions to assess the robustness of our inferences (PPCs). Finally, we use hindcasting to calibrate and strengthen our inferences. To our knowledge, all these approaches are novel in EUR forecasting.
Using a Bayesian framework with a low-dimensional (two-parameter) physics-based model provides a fast and reliable technique to quantify the uncertainty in production forecasts. In addition, the use of parallel chains with an adaptative M-H MCMC accelerates the rate of convergence and increases the robustness of the method.
Evaluating the Impact of COVID-19 Pandemic on The Physicians’ Psychological Health; A Scoping Systematic Review
Authors: Guraya Shaista Salman , Menezes Prianna , Lawrence Isabell Nelson , Guraya Salman Yousuf , Rashid-Doubell Fiza 
Published: March 2022

Abstract
Background COVID-19 has endangered healthcare systems at multiple levels worldwide. Published data suggests that moral dilemmas faced during these unprecedented times have placed physicians at the intersections of ethical and unethical considerations. This phenomenon has questioned the physicians' morality and how that has affected their conduct. Our review taps into the spectrum of the transforming optics of patient care during the pandemic and its impact on psychological wellbeing.Methods We adopted the Arksey and O’Malley’s framework, defining research questions, identifying relevant studies, selecting the studies using agreed inclusion and exclusion criteria, charting the data, and summarizing and reporting results. Databases of PubMed/Medline, Web of Science, Scopus, Science Direct, CINAHL, and PsycInfo were searched using a predefined search string. The retrieved titles and abstracts were reviewed. Later, a detailed full-text analysis of the studies which matched our inclusion criteria was performed. ResultsOur first search identified 875 titles and abstracts. After excluding duplicates, irrelevant, and incomplete titles, we selected 28 studies for further analysis. The total sample size in 28 studies was 15,509 with an average sample size of 637 per study. Both quantitative and qualitative approaches were used, with cross-sectional surveys being utilized in all 16 quantitative studies and the most common qualitative study design used semi-structured interviews. A number of discrete codes were generated which led to the identification of five main themes; mental health, individual challenges, decision-making, change in patient care, and support services.ConclusionThis scoping review reports an alarming rise in psychological distress, moral injury, cynicism, uncertainty, burnout and grief among physicians during the pandemic. Decision-making and patient care was mostly regulated by rationing, triaging, age, gender and life expectancy. Poor professional controls and institutional services potentially led to physicians’ crumbling wellbeing. This research calls for the remediation of the deteriorating mental health and restoration of medical profession’s advocacy and equity.
Choroidal vascularity index changes in chronic migraine patients
Authors: Sezer Taha 
Published: March 2022

Abstract
Purpose: Migraine is a neurovascular disorder characterized by recurrent headaches. The relationship between migraine disease and the choroid, has been examined in an attempt to elucidate the underlying pathophysiological mechanisms. This study evaluated choroidal vascularity index (CVI) in chronic migraine patients.Methods: In this prospective study, we compared CT and CVI values of 36 chronic migraine patients (30 women and 6 men) during an attack-free period with those of 36 healthy individuals (30 women and 6 men) with no systemic or ocular disease, including headache. All patients underwent a detailed eye examination before enhanced depth imaging optical coherence tomography (EDI-OCT) imaging. Migraine patients were grouped as those with and without aura and were asked to rate their headache severity on visual analog scale (VAS; range 1-10) and estimate their monthly migraine frequency.Results: The mean subfoveal CT (SFCT) was 300.52 ± 88.30 µm in the migraine group and 262.85 ± 70.68 µm in the control group. The mean CVI was 71.8% ± 6.2% in the migraine group and 70.7% ± 5.3% in the control group. SFCT and CVI did not differ significantly between the migraine and control groups (p>0.05). VAS pain score was 8.17 ± 0.33 in the migraine group and was not correlated with SFCT (r=0, p=0.998) or CVI (r=−0.06, p=0.731). The monthly migraine frequency was 5.60 ± 3.60 and was not correlated with SFCT (r=−0.17, p=0.328) or CVI (r=−0.06, p=0.731).Conclusion: CT and CVI showed no significant differences from controls in chronic migraine patients during an attack-free period.
Evaluation of Daily Suspended Sediment Load Using Deep Learning Models
Authors: Sahoo Bibhuti Bhusan , Dalai Chitaranjan , Srika B , Bhushan Mani 
Published: March 2022

Abstract
Precise and reliable suspended sediment load (SSL) prediction models can help ensure the integrated water resources management in a river basin. This study considered two deep learning (DL) models i.e. gated recurrent unit (GRU) and long short term memory (LSTM) for daily SSL modeling in the Missouri River at Omaha, NE gauging station in the United States. The established models are verified with various statistical measures. The assessment of prediction accurateness of the DL models showed that the GRU was the best model in SSL prediction. The coefficient of determination was 0.871 for the GRU and 0.865 for LSTM. Besides, the GRU model has a lesser root mean square error (RMSE) and mean absolute error (MAE) compared to the LSTM. In summary, both the developed DL model can be used competently in SSL modeling. However, GRU utilizes less training constraints and thus uses a lesser amount of memory, performs quicker, and trains faster than LSTM, while LSTM needs additional data to be more accurate.
Sorafenib Inhibits Interferon Production by Plasmacytoid Dendritic Cells in Hepatocellular Carcinoma
Authors: Zhang Xinning , Xu Yong , Zhao Guodong , Liu Rong , Yu Haisheng 
Published: March 2022

Abstract
Background：Sorafenib is a multi-kinase inhibitor that shows antitumor activity in advanced hepatocellular carcinoma. Sorafenib exerts a regulatory effect on immune cells, including T cells, natural killer cells and dendritic cells. Studies have shown that plasmacytoid dendritic cells (pDCs) are functionally impaired in cancer tissues or produce low IFNα in cancer microenvironments. However, the effects of sorafenib on the function of pDCs have not been evaluated in detail.Methods: Normal and patient PBMCs were stimulated with CpG-A to evaluate IFNa production with Flow cytometry and ELISA. Result: We analyzed the production of type I interferon (IFNα) by PBMCs in patients with advanced HCC under sorafenib treatment. We found that sorafenib-treated HCC patients produced less IFNα than untreated patients. Furthermore, we demonstrated that sorafenib suppressed the production of IFNα by PBMCs or pDCs from heathy donors in a concentration-dependent manner. Conclusion: Sorafenib suppressed pDCs function. Given that sorafenib is a currently recommended targeted therapeutic agent against cancer, our results suggest that its immunosuppressive effect on pDCs should be considered during treatment.
Real-time Intelligent Diagnosis of Co-Frequency Vibration Faults in Rotating Machinery Based on Lightweight-Convolutional Neural Networks
Authors: Pan Xin , Zhang Xiancheng , Jiang Zhinong , Bin Guangfu 
Published: March 2022

Abstract

The co-frequency vibration fault is one of the common faults in the operation of rotating equipment, and realizing the real-time diagnosis of the co-frequency vibration fault is of great significance for monitoring the health state and carrying out vibration suppression of the equipment. In engineering scenarios, co-frequency vibration faults are highlighted by rotational frequency and difficult to identify, and existing intelligent methods require more hardware conditions and exclusive time-consuming. Therefore, lightweight-Convolutional Neural Networks (LW-CNN) algorithm is proposed in this paper to achieve real-time fault diagnosis purpose. For the sliding window data augmentation method, the important parameters are discussed and verified by simulated and experimental signals. Based on LW-CNN and data augmentation, the real-time intelligent diagnosis of co-frequency is realized. Moreover, a real-time detection method of fault diagnosis algorithm is proposed for the process from data acquisition to fault diagnosis. It is verified by experiments that the LW-CNN and sliding window method are used with high accuracy and real-time performance.
Attitude and Perception Towards Medical Documentation Among Pre-Intern Doctors in Sri Lanka
Authors: Padeniya A.B , Hathamuna A.I , Abeysinghe W.S.P , Gunawardena A , Mahipala P , Epitakaduwa C , Ranasinghe J.M.S.D , Colambage P , Denuwara H.M.B.H , Marasinghe A , Wijesekara L.J , Weerasinghe K , Wijayarathna N.D.S.K , Jayawickrama W.I.U , Mahesh P.K.B 
Published: March 2022

Abstract
IntroductionA properly documented medical record is a vital component in good clinical care. A medical record lies as a core of health information system in the hospital. Medical document is a record pertaining to clinical assessment, medical care, professional judgment and critical thinking by a health professional in relation to providing patient care. There is a paucity of studies in Sri Lankan literature to assess attitudes and competencies among pre-intern doctors on medical documentation. AimTo describe the Attitude and perception towards medical documentation among pre-intern doctors in Sri Lanka Methods A descriptive cross-sectional study was carried out among 641 pre-interns who were eligible for medical internship in 2020. A pre-tested self-administered questionnaire was used to collect data. The objective of the study was to determine attitude and perception towards medical documentation among pre-intern doctors. Pre-interns who joined for the Good Intern Programme, in year 2020 were invited to participate for the study. Descriptive statistical analyses were done. Results Mean age of the participants was 27.6 (SD 1.4) years and majority of them were females (66.5%). Majority (92.20%) of pre- interns perceived that if a patient leaves against medical advice, it is a duty of the doctor to issue a diagnosis card to the patient. Majority (91.73%) believed that they have to give a diagnosis card even for the simple viral fever. Around 69.42% of pre- interns have got a chance to participate for any training on writing diagnosis cards within last 3 years while majority (74.26%) of them perceived that they have received an adequate training in diagnosis card writing so far. Fifty-eight percent of them specified as they learnt to write diagnosis card by observing it during ward work. Majority (52.26%) of the participants perceived that they have satisfactory level of competency in writing a diagnosis card. Meanwhile majority (88.3%) of participants perceived that they need a training on proper way of writing a diagnosis card prior to the internship.ConclusionThis study highlights the importance of adding training components on medical documentation to undergraduate medical curricula and having refresher trainings prior to the commencement of medical internship.
New insights in amelioration of rhabdomyolysis-induced acute kidney injury by triple effect of Diallyl trisulphide and Sildenafil on apoptosis, NF-κB and NRF-2/HO-1 signaling crosstalk
Authors: Khalil Rania , El-Tanbouly Ghada S. 
Published: March 2022

Abstract
Acute kidney injury is a crucial complication of rhabdomyolysis. Glycerol (Gly) is used for induction of rhabdomyolysis in rats. Diallyl trisulphide (DATS) is a natural product from garlic with reported anti-inflammatory/antioxidant activities. Sildenafil (Sild) is a phosphodiesterase-5 inhibitor, selected in this study for its experimental protective effects in muscle and kidney injuries. Herein, protective effects of DATS and Sild were investigated in rhabdomyolysis-induced acute kidney injury (RIAKI) model. Rats were separated into five groups: Control (saline, i.p.), Gly (10 ml/kg, i.m.), Gly+Sild (5mg/kg, oral), Gly+DATS (10 and 20 mg/kg, i.p.), and tested 24 hrs after injury. Renal and muscle function tests: Serum BUN, creatinine, total CK, CK-MB, in addition to urine creatinine, total protein and albumin were measured. Renal oxidant/antioxidant status and histopathological changes, were also measured. Meanwhile, renal NRF-2, HO-1, IL-1β and IL-6, were assessed by ELISA. Furthermore, inflammation (TNF-α, NF-κBp65, COX-2) and apoptosis (BAX/BCL-2) were examined by immunohistochemistry. The study showed that DATS, in a dose-dependent manner improved RIAKI, through reduction of mortality, renal damage, muscle injury, oxidative stress inflammation and apoptosis, in addition to improvement of kidney function and anti-oxidant defense. DATS prevented nuclear translocation of NF-κBp65 and BAX. Otherwise, DATS elevated nuclear translocation of BCL-2 and expression of NRF-2/HO-1, thus modulating the crosstalk between these pathways. In the meantime, sildenafil, to a reduced extent, monitored the same pathways and proved its muscle/reno-protective actions. Therefore, DATS can be a natural candidate for treatment of acute muscle and kidney injuries, via its verified antioxidant, anti-inflammatory and antiapoptotic potentials.
Relation between the Sense of Strain, Social Control, Differential Associations and Juvenile Delinquency Amongst Adolescents: An Empirical Test of Robert Agnew’s General Strain Theory
Authors: Jurczyk Marcin 
Published: March 2022

Abstract
The main aim of this work was to explore the existing correlation between variables in the scope of the strain (its types), social control, differential associations and illegal and anti-social behaviors demonstrated by youth offenders and high school students’. In total 266 young people were assessed in the age of 16 to 18 years old. This research involved two groups of adolescents: youth offenders and high school students. The results show that strain as the presentation of negative stimuli the most significantly predict an increase in the intensity of behavior violating legal and social norms among youth offenders. Data provide qualified support for the theory. The results could be used in the prevention of criminal behavior, therapy, social rehabilitation, and in criminal and social policy.
Function Study of RNF43 in Colon Cancer and CRISPR Detection of its Mutation
Authors: Wang Zhen , Shi Suping , Bian Chengling , Yan Feihu 
Published: March 2022

Abstract
Purpose
In the present study, we aimed to study the expression levels and functional role of RNF43 in colon cancer, and provid a new theoretical basis and research direction for assessing the risk of colon cancer.
Methods
We used bioinformatics to analysis the expression and effect of RNF43 in colon cancer. Cell proliferation, migration and invasion were detected by CCK-8, Transwell and wound healing experiments. The CRISPR-cas12a was used to detecte the mutation sites of RNF43. Meanwhile, Sanger sequencing was used to recheck.
Results
RNF43 is up-regulated in colon cancer and participated in the signal pathway in tumors. In vitro cell experiments revealed that RNF43 inhibits the proliferation, migration and invasion of colon cancer cells. Finally, rs786205215 and rs1567880628 were found to have higher mutation frequencies and the results of the two detection methods are completely consistent.
Conclusion
Studies have shown that rs786205215 and rs156788062 of RNF43 may be used as indicators for colon cancer risk prediction, and CRISPR-cas12a system can be identified as one of the detection methods of SNP sites.