bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bringing it all together
Authors: Potter Rich , Horn Christian , Meijer Ellen 
Published: August 2022

This paper presents the results of a photogrammetric survey of the rock art panel Tanum 247:1 in Kalleby, which revealed an entirely new boat that had previously been missed in a documentation history over 50 years long. Through the combined use of digital and traditional methods the results could be verified. It is therefore argued that collating documentations, both past and present, can help to create a better picture of Bronze Age rock art carvings. In addition to using new and traditional documentation methods together, panels should be recorded beyond what is known, both in terms of discovering unknown carvings, as well as creating better data for future researchers.
Integrated bioinformatics analysis identifies the effects of Sema3A/NRP1 signaling in oligodendrocytes after spinal cord injury in rats
Authors: Hu Rong , Shi Mengting , Xu Haipeng , Wu Xingying , He Kelin , Chen Yi , Wu Lei , Ma Ruijie 
Published: August 2022

Objective
To investigate the effect of Sema3A/NRP1 signaling in oligodendrocytes (OLs) after spinal cord injury.

Methods
Three analysis strategies, namely differential expression gene analysis, Gene Ontology (GO) enrichment, and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis, were applied. The protein-protein interaction (PPI) network was constructed using the STRING website to explore the correlation between Sema3A/NRP1 and oligodendrocytes. Then, the T10 spinal cord segment of rats was injured by the Allen method to establish a spinal cord injury (SCI) model. Real-time quantitative PCR, Western blotting, Nissl staining and immunofluorescence staining were used to detect the effect of Sema3A/NRP1 signaling on oligodendrocytes in vivo.

Results
After the SCI model was established, significantly fewer oligodendrocytes were observed. At the same time, R software was used to analyze the expression of related genes, and NRP1 expression was increased. PCR also demonstrated similar results, and NRP1 ligand Sema3A was also upregulated. KEGG and GO functional enrichment analysis indicated that the SCI model was mainly related to cytokine interaction, cell proliferation, differentiation and maturation. Interestingly, we found that NRP1 was involved in semaphorin-plexin signaling pathway neuronal projection guidance and axon guidance, mediating cell growth and migration. Moreover, Sema3A/NRP1 signaling was closely associated with platelet-derived growth factor receptor α (PDGFRα) in the PPI network. When Sema3A/NRP1 signaling was specifically blocked at early stages, PDGFRα expression was effectively inhibited, and the expression of OLs was promoted. Furthermore, inhibition of Sema3A/NRP1 signaling increased the Basso-Beattie-Bresnahan (BBB) score of lower limb motor function in SCI rats and promoted the survival of motor neurons in the ventral horn of the injured spinal cord.

Conclusion
Our data suggest that Sema3A/NRP1 signaling may regulate the development of OPCs and OLs after SCI, thereby affecting functional recovery.
Effect of Oral Sodium Bicarbonate in Maintaining Acid Base Balance and Qol in Chronic Kidney Disease and Long-Term Acidosis Patients
Authors: Priyanka Singamsetty Lakshmi , Tara Syed Kaifa , Sireesha Vatam , Farahana Patan Maneesha , Baba Kudipudi Harinadha , Roby Kanamala Arun Chand 
Published: August 2022

AIM: Aim of the study is to determine the effect of oral sodium bicarbonate in maintaining acid base balance and quality of life in chronic kidney disease and long-term acidosis patients.
Study Design: A prospective observational study.
Study Population: Approximately 174 people who came to nephrology department, Selected based upon inclusion and exclusion criteria.
Study Criteria / Patient Enrollment: Patients are enrolled in study based on inclusion and exclusion criteria.
Inclusion Criteria: The patients who are diagnosed with CKD and receiving oral sodium bicarbonate as part of treatment
Exclusion Criteria: the patients who are having other comorbidities, hypertension, diabetes, and other cardiovascular problems who are not given with oral sodium bicarbonate.
Study Duration : 6 months (December 2021- May 2022).
Methodology: A prospective observational study on effect of oral sodium bicarbonate in maintaining acid base balance and quality of life in chronic kidney disease and long term acidosis patient’s which was carried out in the Department of nephrology.
Results: Most of the patients are in between the age of 70-80 years, married, with good nutritional status, with minimum 5 months of CKD, approximately 50%of the patients are suffering from HTN along with CKD followed by diabetes. Patients are using OSB for a minimum of 5 months with 500mg dose given thrice a day, along with Calcium channel blockers and pantoprazole. OSB is given as a oral tablet.
Conclusion: Oral bicarbonate is widely used to correct acidosis in advanced CKD, this is not underpinned by trial evidence, and real uncertainty exists regarding the balance of benefit and risk for this intervention. That we concluded that most of the patients using OSB was analyzed from nephrology department in QOL, in maintaining acid-base balance was observed in CKD patients.
AGÊNCIA EPISTÊMICA
Authors: Sosa Ernest 
Published: August 2022

O texto explora uma série de distinções entre estados mentais que podem ser cognitivamente relevantes, bem como entre aqueles que podem ser “autoapresentantes”, a fim de analisar as relações entre eles e o mundo exterior e compreender os tipos de crenças e juízos epistêmicos que podem ensejar. Busca, ainda, reconsiderar o estatuto (porventura epistêmico) de experiências sensórias com conteúdo. O objetivo desse percurso é fazer frente a objeções céticas à justificação epistêmica do tipo daquelas levantadas pelo trilema de Agripa, segundo o qual a avaliação reflexiva não pode regredir infinitamente, circular infinitamente, nem depender de alguma instância arbitrária. Trata-se, também, finalmente, de esclarecer, com as nuances relevantes, a relação entre juízo e liberdade – esclarecimento relevante para a análise mais geral da agência epistêmica. PALAVRAS-CHAVE: Juízo. Agência epistêmica. Liberdade. Conhecimento. Trilema de Agripa. EPISTEMIC AGENCY Ernest Sosa The paper explores a series of distinctions between mental states that might be cognitively relevant, as well as between those that might be “self-presenting”, so as to analyze the relations between these and the external world, and understand the types of beliefs and epistemic judgments for which they allow. The paper also aims to reconsider the (perhaps epistemic) status of contentful sensory experiences. The goal of the journey is to face skeptical objections to epistemic justification akin to those raised by the Agrippan trilemma, according to which reflexive evaluation cannot regress infinitely, be infinitely circular, nor depend upon some arbitrary instance. It is also question of clarifying, with the relevant nuances, the relation between judgment and freedom – a clarification that is of import to the more general question of epistemic agency. KEY-WORDS: Judgment. Epistemic agency. Freedom. Knowledge. Agrippan trilemma. AGENCE ÉPISTÉMIQUE Ernest Sosa Le texte explore toute une série de distinctions entre des états mentaux qui sont ou non cognitivement pertinents, ou qui sont aussi ou non “auto-présentants”, comme manière d’analyser les relations entre ceux-ci et le monde extérieur, et de comprendre les types de croyances et de jugements épistémiques qu’ils peuvent faire surgir. Notre étude cherche également à reconsidérer le statut (peut-être épistémique) d’expériences sensorielles ayant un contenu. L’objectif de ce parcours est de faire face aux objections septiques quant à la justification épistémique de celles soulevées par le trilemme d’Agrippa selon lequel l’évaluation réflexive ne peut régresser indéfiniment, circuler indéfiniment ni dépendre d’une quelconque instance arbitraire. Il s’agit aussi, finalement, d’éclaircir avec des nuances la relation entre jugement et liberté – éclairage significatif pour l’analyse plus générale de l’agence épistémique. MOTS-CLÉS: Jugement. Agence Epistémique. Liberté. Connaissance. Trilemme d’Agrippa. Publicação Online do Caderno CRH no Scielo: http://www.scielo.br/ccrh Publicação Online do Caderno CRH: http://www.cadernocrh.ufba.br
A AFIRMAÇÃO DE UMA SITUAÇÃO SOCIOCOMUNICATIVA: desfile de carnaval e tramas da cultura popular urbana carioca
Authors: Farias Edson Silva 
Published: August 2022

Neste artigo, com o objetivo de acompanhar a dinâmica de estilização sociocomunicativa em que se define o gênero lúdico-estético Desfile de Carnaval, no Rio de Janeiro, a argumentação desenvolvida toma por fio condutor a posição do artista-intelectual carnavalesco. Isto, no andamento da diferenciação funcional relativa à ascensão do cargo e como se afirma sua liderança estética nos desfiles das escolas de samba. Recortamos a análise no intervalo entre as décadas de 1950 e 1980, focando, de um lado, o carnavalesco, na figura do intelectual modernista comprometido com um ideário modernizador, na postura do legislador cultural; de outro lado, o lugar do especialista na concepção e produção de imagens visuais no concerto do superestáculo carnavalesco. PALAVRAS-CHAVE: Sociologia. Cultura Urbana. Desfile de Carnaval. Comunicação.CARNIVAL PARADE AND CULTURAL NETWORKS OF THE URBAN RESIDENTS OF RIO DE JANEIRO Edson Silva Farias In this article, with the aim of following the dynamics of the socio-communicative stylization which fits into the definition of the entertainmentesthetic genre of the Rio de Janeiro Carnival Parade, the guiding principle of the argument developed is the point of view of the carnival intellectualartist. This means the development of the functional differentiation regarding job promotion and how this affects their esthetic leadership in the samba school parades. We will analyze the period from the 1950s to the 1980s, focusing on one hand on the carnival character as a modernist intellectual committed to a set of modernizing ideas, in the position of cultural legislator; on the other hand, focusing on the role of the specialist in the conception and production of visual images in the concert of the carnival super-spectacle. KEY WORDS: Sociology. Urban culture. Carnival parade. Communication.DEFILÉ DE CARNAVAL ET CANEVAS DE LA CULTURE POPULAIRE URBAINE CARIOCA Edson Silva Farias Dans le but de suivre la dynamique de stylisation socio-communicative dans laquelle se définit le genre ludique et esthétique “Défilé de Carnaval”, à Rio de Janeiro, l’argumentation présentée dans cet article a comme fil conducteur la position de l’artiste-intellectuel carnavalesque. Ceci, dans le cadre d’une différenciation fonctionnelle relative à l’ascension de la tâche et à la manière dont s’affirme son leadership esthétique dans les défilés des écoles de samba. L’analyse se situe dans un intervalle de temps qui va de 1950 à 1980, en mettant l’accent, d’une part, sur le carnavalesque qui se reflète dans la figure de l’intellectuel moderniste engagé dans une idéologie de la modernisation en assumant une posture de législateur culturel et, d’autre part, sur la place du spécialiste en conception et production d’images visuelles, de concert avec le super-spectacle carnavalesque. MOTS-CLÉS: Sociologie. Culture urbaine. Défilé de carnaval. Communication. Publicação Online do Caderno CRH no Scielo: http://www.scielo.br/ccrh Publicação Online do Caderno CRH: http://www.cadernocrh.ufba.br
A CRISE DA HUMANIDADE E A CRÍTICA RADICAL DO VALOR
Authors: Collin Denis 
Published: August 2022

A crise atual não é simplesmente uma crise econômica. É uma crise global que afeta todos os aspectos da vida humana em uma escala mundial. O sistema baseado na acumulação ilimitada de capital não pode mais ser perpetuado sem ameaçar a própria civilização. Neste sentido, é uma crise da humanidade, muito mais do que uma crise econômica. A retomada de conceitoschave marxianos nos permite compreender sua seriedade e profundidade. PALAVRAS-CHAVE: Acumulação de capital. Agricultura. Crise. Regulação. Sistema monetário internacional. THE CRISIS OF HUMANITY AND RADICAL CRITIQUE OF VALUE Denis Collin The current crisis is not simply an economic crisis. It is a global crisis that affects all aspects of human life on a worldwide scale. The system based on the unlimited accumulation of capital can no longer be perpetuated without threaten civilization itself. In this sense, it is a crisis of mankind, much more than an economic crisis. The resumption of marxians key concepts allows us to understand its seriousness and depth. KEY WORDS: Accumulation of capital. Agriculture. Crisis. Regulation. International monetary system. LA CRISE DE L’HUMANITÉ ET LA CRITIQUE RADICALE DE LA VALEUR Denis Collin La crise actuelle n’est pas qu’une simple crise économique. Il s’agit d’une crise globale qui touche à tous les aspects de la vie humaine à une échelle mondiale. Le système basé sur l’accumulation illimitée du capital ne peut plus être perpétué sans menacer la civilisation ellemême. Dans ce sens, c’est une crise de l’humanité bien plus qu’une crise économique. Reprendre les concepts-clés de Marx nous permet de comprendre combien elle est grave et profonde. MOTS-CLÉS: Accumulation du capital. Agriculture. Crise. Règlement. Système monétaire international. Publicação Online do Caderno CRH no Scielo: http://www.scielo.br/ccrh Publicação Online do Caderno CRH: http://www.cadernocrh.ufba.br
Tough Hydrogels with Isotropic and Unprecedented Crack Propagation Resistance
Authors: Li Weizheng , Zheng Sijie , Zou Xiuyang , Ren Yongyuan , Liu Ziyang , Peng Wansu , Wang Xiaoliang , Liu Dong , Shen Zhihao , Hu Yin , Guo Jiangna , Sun Zhe , Yan Feng 
Published: August 2022

AbstractMuscles and some tough hydrogels can maintain perfect mechanical properties after millions of loading cycles owing to the anisotropic microstructures inside them. However, applications of intrinsic anisotropic microstructures in biological tissues and tough hydrogels are limited by the poor mechanical performance in the perpendicular direction relative to the alignment direction. Here, a universal strategy is proposed for developing hydrogels with unprecedented isotropic crack propagation resistance only depending on the interpenetrating entanglements of polymer chains (polyacrylamide (PAAM) or poly‐(1‐acrylanmido‐2‐methylpropanesulfonic acid) (PAMPS)) in deformable polymeric microspheres (PAMPS or PAAM). The deformable interpenetrating network in microspheres can transform the hydrogel from isotropic to anisotropic instantaneously in any load direction, and effectively alleviate the stress concentration at the crack tip, dissipate energy, and eliminate notch sensitivity. The best isotropic hydrogel displays an ultimate strain of 5300%, toughness of 18.9 MJ m–3, fracture energy of 157 kJ m–2, and fatigue threshold of 4.2 kJ m–2. Furthermore, the mechanical strength of hydrogels can be simply tuned by solvent replacement. The strategy presented here can be expanded to prepare other isotropic hydrogels with super tear‐resistant and anti‐fatigue properties, based on a wide variety of deformable microspheres and matrix polymers.
Efficient Room‐Temperature Voltage Control of Picosecond Optical Spin Orientation Using a III‐V Semiconductor Nanostructure
Authors: Park Soyoung , Hiura Satoshi , Takayama Junichi , Sueoka Kazuhisa , Murayama Akihiro 
Published: August 2022

AbstractManipulation of the optical spin orientation in semiconductors is a key technology for realizing spin‐based photoelectric information processing. Application of magnetic field is a simple method to control the spin polarization degree through Zeeman splitting. However, this effect can only be achieved at cryogenic temperatures and in a strong magnetic field. Here, room‐temperature voltage control of optical polarization in the range of 3–15%, corresponding to a 12–60% change in relative spin polarization is demonstrated. For this, a III‐V semiconductor quantum dot tunnel coupled with a quantum well spin reservoir is used. The spin‐flip scattering rate within quantum dots is electric‐field‐controlled in the time domain of several tens of picoseconds. This is achieved by precise control of the tunnel injection efficiency of electrons and holes via coupled potential modification. The findings will pave the way for the generation of ultrafast spin‐modulated optical signals by the electric field effect.
Selection against early flowering in geothermally heated soils is associated with pollen but not prey availability in a carnivorous plant
Authors: Valdés Alicia , Helmutsdóttir Vigdís F. , Marteinsdottir Bryndís , Ehrlén Johan 
Published: August 2022

AbstractPremiseIn high‐latitude environments, plastic responses of phenology to increasing spring temperatures allow plants to extend growing seasons while avoiding late frosts. However, evolved plasticity might become maladaptive if climatic conditions change and spring temperatures no longer provide reliable cues for conditions important for fitness. Maladaptative phenological responses might be related to both abiotic factors and mismatches with interacting species. When mismatches arise, we expect selection to favor changes in phenology.MethodsWe combined observations along a soil temperature gradient in a geothermally heated area with pollen and prey supplementation experiments and examined how phenotypic selection on flowering time in the carnivorous plant Pinguicula vulgaris depends on soil temperature, and pollen and prey availability.ResultsFlowering advanced and fitness decreased with increasing soil temperature. However, in pollen‐supplemented plants, fitness instead increased with soil temperature. In heated soils, there was selection favoring later flowering, while earlier flowering was favored in unheated soils. This pattern remained also after artificially increasing pollen and prey availability.ConclusionsPlant–pollinator mismatches can be an important reason why evolved plastic responses of flowering time to increasing spring temperatures become maladaptive under novel environmental conditions, and why there is selection to delay flowering. In our study, selection for later flowering remained after artificially increasing pollen availability, suggesting that abiotic factors also contribute to the observed selection. Identifying the factors that make evolved phenological responses maladaptive under novel conditions is fundamental for understanding and predicting evolutionary responses to climate warming.
ADHD‐associated PARK2 copy number variants: A pilot study on gene expression and effects of supplementary deprivation in patient‐derived cell lines
Authors: Radtke Franziska , Palladino Viola Stella , McNeill Rhiannon V. , Chiocchetti Andreas G. , Haslinger Denise , Leyh Matthias , Gersic Danijel , Frank Markus , Grünewald Lena , Klebe Stephan , Brüstle Oliver , Günther Katharina , Edenhofer Frank , Kranz Thorsten M. , Reif Andreas , Kittel‐Schneider Sarah 
Published: August 2022

AbstractRecent studies show an association of Parkin RBR E3 ubiquitin protein ligase (PARK2) copy number variations (CNVs) with attention deficit hyperactivity disorder (ADHD). The aim of our pilot study to investigate gene expression associated with PARK2 CNVs in human‐derived cellular models. We investigated gene expression in fibroblasts, hiPSC and dopaminergic neurons (DNs) of ADHD PARK2 deletion and duplication carriers by qRT PCR compared with healthy and ADHD cell lines without PARK2 CNVs. The selected 10 genes of interest were associated with oxidative stress response (TP53, NQO1, and NFE2L2), ubiquitin pathway (UBE3A, UBB, UBC, and ATXN3) and with a function in mitochondrial quality control (PINK1, MFN2, and ATG5). Additionally, an exploratory RNA bulk sequencing analysis in DNs was conducted. Nutrient deprivation as a supplementary deprivation stress paradigm was used to enhance potential genotype effects. At baseline, in fibroblasts, hiPSC, and DNs, there was no significant difference in gene expression after correction for multiple testing. After nutrient deprivation in fibroblasts NAD(P)H‐quinone‐dehydrogenase 1 (NQO1) expression was significantly increased in PARK2 CNV carriers. In a multivariate analysis, ubiquitin C (UBC) was significantly upregulated in fibroblasts of PARK2 CNV carriers. RNA sequencing analysis of DNs showed the strongest significant differential regulation in Neurontin (NNAT) at baseline and after nutrient deprivation. Our preliminary results suggest differential gene expression in pathways associated with oxidative stress, ubiquitine‐proteasome, immunity, inflammation, cell growth, and differentiation, excitation/inhibition modulation, and energy metabolism in PARK2 CNV carriers compared to wildtype healthy controls and ADHD patients.
Valproic acid induced selective apoptosis of ocular fibrous tunic in mice fetuses
Authors: Manthos Kyriakos , Theotokis Paschalis , Dermitzakis Iasonas , Avramidou Eleni , Meditskou Soultana , Manthou Maria Eleni , Emmanouil‐Nikoloussi Elpida‐Niki 
Published: August 2022

AbstractBackgroundValproic acid (VPA), a prescribed drug commonly used for various neurological perturbations, has been implicated in teratogenic inflictions on developing fetuses during pregnancy. The purpose of this research was to delineate the gross morphological and histological effects of VPA in the developing eye tunics and lens.MethodsA time‐dependent administration of 500 mg/kg VPA to BALB/c groups of female mice was coordinated during organogenesis (gestational days 7, 8, and 9) and compared to controls that received normal saline. Seized fetuses were checked for macroscopic eye anomalies, histological malformations with Azan trichrome staining, and levels of apoptotic activity with the terminal deoxynucleotidyl transferase‐mediated nick end labeling (TUNEL) assay.ResultsHistochemical analysis showed that VPA‐treated groups exhibited collagen deficiency (2.5–50% decrease in aniline blue intensity) and a marked increase in TUNEL‐positive cells (p < .05) in corneal stroma and sclera/choroid layers while less was detected in retina and lens, when compared to controls.ConclusionsSince the evaluation of the inner structures did not manifest major differences, we conclude that VPA teratogenic influence display eclectic toxicity, as seen by increased apoptosis to eye layers with high degree fibrous context, particularly the outer tunics.