bluuebunny/crossref_metadata_2025_split huggingface dataset:
Urinary Extracellular vesicles abundance of SLC12A3 (NCC) increase and Aquaporine2 decrease following DASH diet implementation
Authors: Bielopolski Dana , Musante Luca , Molina Henrik , Barrows Douglas , Carrol Thomas , Tobin Jonathan N. , Kost Rhonda. G , Erdbruegger U 
Published: November 2022

AbstractThe Dietary Approach to Stop Hypertension (DASH) diet is a proven intervention to treat hypertension, yet its mechanism is not clearly known. We investigated the change in protein abundance patterns in urine extracellular vesicles (uEV’s) following DASH diet implementation.A pilot study was carried out to compare uEVs isolated using three different methods: a low centrifugation (P20), high centrifugation (P100), and a combination of both (P20 and P100). Uromodulin was removed by size exclusion chromatography and low ionic strength washing. Mass spectrometry analysis identified 1,593 proteins in the combined fraction (P20+P100), 1434 in the P20 fraction and 1229 in the P100 fraction. The combined fraction was chosen for further analysis. Statistical analysis was carried out using R and Limma to identify all proteins that changed before and during 11 days of DASH intervention (p < 0.05) as well as between individual timepoints.Nine hypertensive volunteers were admitted for a 14-day supervised transition from American style diet to DASH diet. First-void urine was collected on days 0, 5, 11 for uEV processing. In total, 1800 proteins were identified across all 27 DASH samples with 22 proteins upregulated and 25 down regulated between day 0 and both days 5 and 11. These included increased abundance of SLC12A3 (NCC) and reduced abundance of Aquaporine 2.These changes could explain the increased urine volume and reduced sodium reabsorption that lead to blood pressure reduction following consumption of the high potassium and low sodium DASH diet. uEVs may serve as a surrogate to a more invasive procedure.Translational StatementMyriad studies have characterized blood pressure reduction following DASH diet implementation, yet its precise mechanism is unclear. Here, we demonstrate for the first time the effect of DASH nutritional changes, on kidney ion channel composition using proteomic analysis of urinary EVs. Using this innovative tool as a substitute for an invasive procedure, we show that the expression of Aquaporine2 increases and NCC decreases in response to DASH which may account for its antihypertensive effect. Our results indicate that urinary EV are a potential biomarker for DASH compliance, and targeting aquaporine2 may be an effective innovative therapeutic strategy for blood pressure reduction.
Polyvalent mRNA vaccination elicited potent immune response to monkeypox surface antigens
Authors: Fang Zhenhao , Renauer Paul A. , Suzuki Kazushi , Chen Sidi 
Published: November 2022

AbstractThe soaring global monkeypox cases lead to a surge in demand for monkeypox vaccine, which far exceeds the supply. mRNA vaccine has achieved great success in prevention of coronavirus disease and holds promise against diverse pathogens. In this study, we generate a polyvalent lipid nanoparticle (LNP) mRNA vaccine candidate for monkeypox virus (MPXV) and evaluate its immunogenicity in animal models. This polyvalent MPXV mRNA vaccine candidate, MPXVac-097, encodes five 2022 MPXV targets that are important surface antigens. Three-dose (prime-boost-booster) MPXVac-097 vaccination elicits strong antibody response to A35R and E8L antigens, moderate response to M1R, but not B6R or A29, highlighting the differences in immunogenicity. Bulk T cell receptor (TCR) sequencing reveals preferential usage of VJ combinations and clonal expansion of peripheral T cells after MPXVac-097 vaccination. These data demonstrate initial feasibility of developing MPXV mRNA vaccine and pave the way for its future optimization.
Strategic positioning of projects in crowdfunding platforms: do advanced technology terms referencing, signaling and articulation matter?
Authors: Zheng Yilong , Wang Yiru , Mian Sarfraz A. 
Published: November 2022

PurposeTracking trends in new technology funding patterns is essential for venture scaling. The emerging advanced digital technologies (ADT) such as virtual reality (VR), artificial intelligence (AI), blockchain and Internet-of-things (IoT) promote business innovation adaptations, and in turn, reshape the industrial landscape. To attract nascent funding for such prospective projects among the public, well-articulated project pitches that are equipped with effective marketing communication convey the projects' importance and marketability. Specifically, when the entrepreneurs and the crowdfunding platform users interact via different types of crowdfunding platforms, pitch framing, including the signaling of ADT terms, project location and fundraising goal, becomes imperative to help facilitate crowdfunding success.Design/methodology/approachDrawing on data collected from six leading US-based equity and reward-based crowdfunding platforms in 2020, an empirical study was performed. Using the text analysis approach, the authors examined the positive effects of incorporating technology orientation on crowdfunding success. While the effect between the project description's signaling of geographic location, fundraising goal and articulation style on fundraising success, while controlling for project and platform characteristics.FindingsThe results suggested that the technology-orientated projects are more likely to achieve better fundraising outcomes. Taking crowdfunding platform types, project locations, minimum fundraising goals and articulation with analytical and authentic into consideration, the results still hold.Originality/valueBuilding on the theoretical framework of signaling theory, the authors consider the crowdfunding-specific contextual factors to enhance the understanding of the positivity impact of technology orientation. By such addition, it facilitates more effective strategic composition of entrepreneurs' fundraising conversations.
From what we know to what we do: Human resource management intervention to support mode 2 healthcare research
Authors: Currie Graeme , Spyridonidis Dimitrios 
Published: November 2022

AbstractThere is a huge volume of evidence about what is clinically effective and efficient, but this is slow to translate into frontline practice. To address the problem, we need to support clinical academics and practitioners to co‐produce research and service improvement; necessitating HRM intervention. Our case study shows common purpose in mode 2 research across clinical academics and practitioners can be attained by focussing upon their professional identity, within which their status and jurisdictional autonomy are key dimensions. Our study shows how development workshops, through which control is ceded by managers to clinical academics and practitioners, are used to co‐design HRM interventions to support mode 2 research. Relevant HRM interventions are first, performance management that is non‐intrusive and aligns with criteria clinical academics and practitioners value. Second, job design that allows autonomy and status enhancement for clinical academics and practitioners engaging in mode 2 research.
Invasion of the coccinellid community associated with a tropical annual agroecosystem
Authors: Andow David A. , Fontes Eliana M. G. , Pires Carmen S. S. , Souza Lucas M. , Paula Débora P. 
Published: November 2022

Abstract
Detailed understanding of the mechanisms enabling or limiting the impacts of invasive generalist predators is needed. Harmonia axyridis is an invasive generalist coccinellid predator that may have destabilised coccinellid communities worldwide and is an excellent candidate for investigating invasion dynamics.
We evaluated four hypotheses: (1) Nine years after being detected in Central Brazil, Ha. axyridis has dominated the coccinellid community. This is facilitated by (2) its broader aphid prey range than the other aphidophagous coccinellids, (3) its superiority as an asymmetrical intraguild predator, and (4) the invasibility of the present coccinellid community.
We sampled the invertebrate communities associated with six organic vegetable farms in Brazil during 2017 and 2018, conducted a feeding trial to measure prey niche breadth and overlap, and estimated intra‐ and interspecific interaction strengths corresponding to first‐order Lotka‐Volterra parameters to evaluate the strength of intraguild predation and create a community matrix.
We found (1) Ha. axyridis comprised ≤8.3% of the coccinellid community. (2) Hi. convergens had the broadest prey niche and dominated the prey niche of Ha. axyridis. (3) We could not determine from the population data if Ha. axyridis was the dominant intraguild predator because its density was too low and constant. (4) The community matrix indicated that the present‐day coccinellid community was stable.
We conclude Ha. axyridis has not become invasive in Central Brazil, in part because it does not have the broadest prey niche breadth and the present coccinellid community is stable to the present perturbation of Ha. axyridis.
Prevalence and factors associated with pressure injury in patients undergoing open heart surgery: A systematic review and meta‐analysis
Authors: Taghiloo Hamed , Ebadi Abbas , Saeid Yaser , Jalali Farahni Alireza , Davoudian Atefeh 
Published: November 2022

AbstractPressure injuries (PIs) are one of the major and costliest medical problems with severe implications for patients. Cardiovascular surgery patients are at the higher risk of developing surgery‐related PIs. So this study was conducted with the aim of investigating the prevalence and factors associated with PIs in patients undergoing open heart surgery. We identified articles through electronic databases such as Web of Science, Scopus, PubMed, ProQuest; and Persian Databases: SID, Magiran and Irandoc without restriction on language or publication period (from inception through June 2022). Finally, 17 studies that fulfilled eligibility criteria were included in final systematic review and meta‐analysis. Data analyses were conducted using STATA version 14. The pooled prevalence of PI in patients undergoing open heart surgery was 24.06% (95% CI: 17.85–30.27). High heterogeneity was observed across the included studies (I2 = 96.0, P < 0.000). The prevalence by gender was reported as 25.19% (95% CI: 13.45–36.93) in men and 33.36% (95 CI%: 19.99–46.74) in women. The result showed there was statistically significant association between PI and Female sex (Pooled Est: 1.551, 95% CI: 1.199–2.006, z = 3.345, P = 0.001), diabetes (Pooled Est: 1.985, 95% CI: 1.383–2.849, z = 3.719, P = 0.000), advanced age (SMD: 0.33 years; 95% CI: 0.09–0.57), Duration of surgery (SMD: 0.47; 95% CI: 0.19–0.75) and preoperative serum albumin level (SMD: 0.56; 95% CI: 0.14–0.98). The relatively high PIs incidence among patients undergoing open heart surgery suggests that typical PI prevention methods are insufficient for this population. Targeted prevention measures must be developed and implemented.
Log Grading and Knot Identification by Oblique X-Ray Scanning
Authors: Omori C. S. , Schajer G. S. 
Published: November 2022

Abstract
The presence and location of knots within cut lumber substantially controls the physical properties and commercial value of the material. Thus, there is great practical interest in developing ways of choosing the cutting pattern for a log in a sawmill to optimize the arrangement of knots in the resulting cut lumber. X-rays can image the interior of a log to detect the arrangement of the knots; however, traditional radiography measurements are two-dimensional in character and cannot provide the needed depth information. Conversely, computed tomography (CT) can provide the required spatial details but is challenging to do in practice because of its complexity and cost. The research here aims to overcome these concerns by employing a novel “oblique” scanning technique that uses radiography to determine knot orientations with both reasonable accuracy and low cost. Image processing and detection algorithms are developed to locate and orientate the knots automatically within the scanned logs. Detection metrics of precision and recall are used to analyze the performance of the detection algorithm. Results indicate that the oblique scanning method is a viable way to detect and orientate knots within logs with both reasonable accuracy and low cost compared to existing methods. In initial tests, an average circumferential angle accuracy within 15 deg was achieved, with the detection algorithm being able to detect between 60% and 80% of the knots present within the log.
From Kirigami to Hydrogels: A Tutorial on Designing Conformally Transformable Surfaces
Authors: Wang Yue , Ren Yingying , Chen Tian 
Published: November 2022

Abstract
Elastic surfaces that morph between multiple geometrical configurations are of significant engineering value, with applications ranging from the deployment of space-based photovoltaic arrays, the erection of temporary shelters, and the realization of flexible display systems, to understanding the encapsulation and release of viral RNAs. In general, ensuring that a shape with a planar rest configuration can deploy into a target three-dimensional (3D) shape is a nontrivial problem. Moreover, it is difficult to physically realize the local deformations necessary to achieve such global transformation. Here, we give a tutorial on applying conformal mapping to rationalize the geometrical deformation of several microstructure designs. A conformal map is a function that locally preserves angles and shapes but not lengths: some regions are scaled (enlarged or shrunk) more than others. To transform a planar surface to 3D, we implement uniform local scalings as mechanical deformations. Numerous natural and architected material systems exhibit such behavior, including kirigami, origami, hydrogel, linkage mechanisms, and fabric membranes. The design and fabrication of conformally transformable surfaces is a transdisciplinary challenge involving insights from advanced manufacturing, computational design, material science, and mechanics. By recognizing that many material systems exhibit isotropic deformation, we hope to inspire researchers to adopt conformal mapping in designing next-generation surface-based engineering systems.
Physiological, Spatiotemporal, Anthropometric, Training, and Performance Characteristics of a 75-Year-Old Multiple World Record Holder Middle-Distance Runner
Authors: Van Hooren Bas , Plasqui Guy , Lepers Romuald 
Published: November 2022

Purpose: This study assessed the cardiorespiratory capacity, anaerobic speed reserve, and anthropometric and spatiotemporal variables of a 75-year-old world-class middle-distance runner who previously obtained several European and world records in the age categories of 60–70 years, achieved 13 European titles and 15 world champion titles, and also holds several European records for the 75-year-old category. Methods: Heart rate, oxygen uptake, carbon dioxide production, ventilation, step frequency, contact time, and velocity at maximal oxygen uptake (VO2max) were measured during treadmill running. Maximal sprinting speed was assessed during track sprinting and used to compute anaerobic speed reserve. Body fat percentage was assessed using air displacement plethysmography. Results: Body fat percentage was 8.6%, VO2max was 50.5 mL·kg−1·min−1, maximal ventilation was 141 L·min−1, maximum heart rate was 164 beats·min−1, maximum respiratory exchange ratio was 1.18, and velocity at VO2max was 16.7 km·h−1. The average stride frequency and contact time during the last 30 seconds of the 4-minute run at 10 km·h−1 were 171 steps·min−1 and 241 ms and 187 steps·min−1 and 190 ms in the last 40 seconds at 17 km·h−1, respectively. The anaerobic speed reserve was 11.4 km·h−1, corresponding to an anaerobic speed reserve ratio of 1.68. Conclusion: This 75-year-old runner has an exceptionally high VO2max and anaerobic speed reserve ratio. In addition, his resilience to injuries, possibly due to a relatively high volume of easy runs, enabled him to sustain regular training since his 50s and achieve international performance in his age group.
Association of different digital media experiences with paediatric dry eye in China: a population-based study
Authors: Ma Junxin , Zhu Hui , Guo Wei , Li Rui , Shen Shiya , Wang Yun , Huang Dan , Zhang Xiaohan , Fu Zhujun , Zhao Andi , Chen Danni , Si Jiahao , Zhang Jiyu , Xu Shasha , Wang Liyuan , Liu Hu 
Published: November 2022

ObjectiveTo investigate the ocular surface effects of different digital media experiences in Chinese elementary school students.DesignPopulation-based cross-sectional study was used.Setting14 randomly selected primary schools in Yuhuatai District, Nanjing, ChinaParticipants2,694 students between 7 and 8-year-old.Outcome MeasuresPrevalence of and risk factors for different types of dry eye disease，and different digital media experience with different ocular signs.ResultsThe prevalence of ‘symptomatic DED’ was 8.7% (95% CI 7.6% to 9.8%) and ‘definite DED’ prevalence rate was 5.5% (95% CI 4.7% to 6.4%). In multivariable logistic regression model, allergic conjunctivitis (OR=4.33, 95% CI (3.01 to 6.23), p<0.001), more than 1 hour per day on outdoor activity (OR=0.69, 95% CI (0.49 to 0.99), p=0.043), smartphone (OR=2.73, 95% CI (1.51 to 4.91), p=0.001), tablet (OR=2.09, 95% CI (1.07 to 4.07), p=0.030) and homework (OR=1.86, 95% CI (1.22 to 2.83), p=0.004) were independently associated with ‘definite DED’, while allergic conjunctivitis (OR=5.58, 95% CI (4.12 to 7.55), p<0.001), more than 1 hour per day on outdoor activity (OR=0.72, 95% CI (0.53 to 0.97), p=0.028), smartphone (OR=2.60, 95% CI (1.55 to 4.35), p<0.001), tablet (OR=1.84, 95% CI (1.02 to 3.34), p=0.044) and homework (OR=2.57, 95% CI (1.84 to 3.60), p<0.001) were independently associated with ‘symptomatic DED’.ConclusionsUsing smartphones or tablets for an average of more than 1 hour per day through the course of a year is independently associated with paediatric DED.
Portable ultrasound technologies for estimating gestational age in pregnant women: a scoping review and analysis of commercially available models
Authors: Eggleston Alexander John , Farrington Elise , McDonald Steve , Aziz Samia 
Published: November 2022

ObjectivesTo identify all available studies assessing the use of portable ultrasound devices for pregnant women, with the specific aim of finding evidence for devices used to determine gestational age and their validity when compared with conventional ultrasound machines. We also wanted to determine what portable ultrasound models are commercially available for obstetric use.DesignSystematic scoping review.Primary and secondary outcome measuresExtracted variables included study design, population, method of ultrasound measurement, devices used and whether studies formally validated accuracy against conventional ultrasound.ResultsWe searched four databases—Medline, Embase, CINAHL and Maternal and Infant Care. In total 56 studies from 34 countries were identified; most were observational studies. Across all studies, 27 different portable ultrasound models (from 17 manufacturers) were evaluated. Twenty-one studies assessed use of portable ultrasound for evaluating fetal characteristics or estimating gestational age, and 10 of these were formal validation studies. In total, six portable devices have been validated for gestational age estimation against a conventional ultrasound comparator. The web searches identified 102 portable devices (21 manufacturers). These were a mix of handheld devices that connected to a phone or computer, or laptop-style portable ultrasound devices. Prices ranged from US$1190 to US$30 000 and weight ranged from 0.9 kg to 13.0 kg.ConclusionWhile the number of commercially available portable ultrasound devices continues to grow, there remains a lack of peer-reviewed, quality evidence demonstrating their accuracy and validity when compared with conventional ultrasound machines. This review identified some models that may be useful in gestational age estimation in low-resource settings, but more research is required to help implement the technology at scale.Trial registration numberRegistered via Open Science Framework (DOI: 10.17605/OSF.IO/U8KXP).
Association of geographic distribution and birth weight with sociodemographic factors of the maternal and newborn child of hilly and mountain regions of eastern Nepal: a cross-sectional study
Authors: Bhattarai Bharosha , Panthi Sagar , Yadav Gopal Kumar , Gautam Swotantra , Acharya Rochana , Neupane Durga , Khanal Nimesh , Khatri Bharat , Neupane Krishna , Adhikari Sugat , Lageju Nimesh , Basnet Lila Bahadur , Pyakurel Prajjwal , Yadav Shankar Prasad 
Published: November 2022

ObjectivesTo determine the association of geographic distribution, and birth weight with sociodemographic factors of the maternal and newborn child of hilly region (lower altitude) and mountain region (high altitude) of eastern Nepal as well as the prevalence of low birth weight (LBW) and large for gestational age (LGA) among term singleton deliveries in eastern Nepal.MethodologyA cross-sectional study was conducted in the district-level hospitals of Dhankuta, Tehrathum, Solukhumbu and Taplejung districts of eastern Nepal of Province 1. Mothers with preterm or post-term delivery, multiple pregnancies, stillbirth/intrauterine fetal death and incomplete records were excluded from the study with only 1386 term pregnancies (37–42 weeks) delivered at the respective facilities between 17 July 2019 and 16 July 2020 were included. The appropriate data were entered in Microsoft Excel 2019 V.16.0 and statistical analysis was performed by using the statistical package for social sciences, IBM SPSS V.29.ResultsThe low maternal age, Dalit ethnic group, low gravidity, low parity, higher antenatal care (ANC) visits (≥4), incomplete deworming and dT vaccination status, breech deliveries and LBW newborns were significantly attributed to hilly region (lower altitude) (p value <0.05). Similarly, the hilly region, lower and/or no ANC visits and early term gestation had significant negative association with birth weight at the lower quantiles only. Meanwhile, the female newborn had significant and negative association with birth weight distribution at all seven quantiles. The prevalence of the LBW, average for gestational age and LGA newborn child among term singleton deliveries in Eastern Nepal is 6.6%, 85.8% and 7.6%, respectively.ConclusionsThe local organisations should focus on adequate antenatal care visits in mountain region and coverage of dT vaccine and deworming medications in hilly region. Appropriate measures and programmes should be initiated to bring down LBW in hilly region.