bluuebunny/crossref_metadata_2025_split huggingface dataset:
DEB-TACE combined with hepatic artery infusion chemotherapy might be an affordable treatment option for advanced stage of HCC
Authors: Kondo Yasuteru , Morosawa Tatsuki , Minami Soichiro , Tanaka Yasuhito 
Published: October 2022

AbstractAlternative treatment modalities are necessary because of the low response rates and unsuitability of molecular-targeted agents (MTA) and/or immune checkpoint inhibitors (iCIs) in HCC patients. Therefore, we analyzed whether drug-eluting beads (DEB)-transcatheter arterial chemoembolization (TACE) with low-dose-FP (Ultra-FP) therapy could improve the efficacy and safety of treatment in difficult-to-treat HCC patients, especially those with advanced stage HCC. From November 2017 to April 2021, 118 consecutive patients with non-resectable difficult-to-treat HCC were included in this study. All patients were treated with Ultra-FP therapy. After the weak DEB-TACE procedure, we administered low-dose FP for 2 weeks followed by resting for 4 weeks. The numbers of HCC patients CR/PR/SD/PD induced by Ultra-FP therapy were 36/52/17/13 (Modified RECIST) patients, respectively. The objective response rate of Ultra-FP therapy was 74.6% (88/118 patients). Tumor marker reduction was observed in 81.4% (96/118 patients). The objective response rate (ORR) in the HCC patients with portal vein tumor thrombosis (PVTT) was 75% (18/24 patients). Median overall survival (mOS) of all included HCC patients was 738 days. The mOS of HCC patients with PVTT (−)/PVTT (+) was 816 days/718 days. The proportion of patients based on ALBI grade system was not significantly different between pre- and after 3 course Ultra-FP therapy. Ultra-FP therapy might be an affordable treatment option for difficult-to-treat advanced HCC. ORR and overall survival after receiving Ultra-FP therapy were remarkable in comparison to various kinds of systemic therapy including MTA and iCIs.
Impact of Obesity on Perioperative Complications on Treatment of Spinal Metastases: A Multicenter Surveillance Study from the German Spine Registry (DWG-Register)
Authors: Vinas-Rios Juan Manuel , Rauschmann Michael , Sellei Richard , Arabmotlagh Mohammad , Medina-Govea Fatima , Meyer Frerk ,   DWG-Register study group
Published: October 2022

Abstract
Background The spine is a common location for the development of primary and metastatic tumors, spinal metastases being the most common tumor in the spine. Spinal surgery in obesity is challenging due to difficulties with anesthesia, intravenous access, positioning, and physical access during surgery. The objective was to investigate the effect of obesity on perioperative complications by discharge in patients undergoing surgery for spinal metastases.
Methods Retrospective analysis of data from the DWG-register on patients undergoing surgery for metastatic disease in the spine from January 2012 to December 2016. Preoperative variables included obesity (≥ 30 kg/m2), age, gender, and smoking status. In addition, the influence of pre-existing medical comorbidity was determined, using the American Society of Anesthesiologists (ASA) score.
Results In total, 528 decompressions with and without instrumentation undergoing tumor debulking, release of the neural structures, or tumor extirpation in metastatic disease of the spine were identified; 143 patients were obese (body mass index [BMI] ≥ 30 kg/m2), and 385 patients had a BMI less than 30 kg/m2. The mean age in the group with BMI 30 kg/m2 or higher (group 1) was 67 years (56.6%). In the group with BMI less than 30 kg/m2 (group 2), the mean age was 64 years. Most of the patients had preoperatively an ASA score of 3 and 4 (patients with severe general disease). The likelihood of being obese in the logistic regression model seems to be protective by 47.5-fold for blood loss 500 mL or higher. Transfusions occurred in 321/528 (60.7%) patients (group 1, n = 122 and group 2, n = 299; p = 0.04). A total of 19 vertebroplasties with percutaneous stabilization (minimally invasive spine [MIS]), 6 vertebroplasties, and 31 MIS alone were identified. The variables between these groups, with exception of preoperative status (ASA-score; p = 0.02), remained nonsignificant.
Conclusion Obese patients were predisposed to have blood loss more than 500 mL more often than nonobese patients undergoing surgery for spinal metastases but with perioperative blood transfusions, invasiveness, nor prolonged hospitalization. Early postoperative mobilization and a low threshold for perioperative venous thromboembolism (VTE) are important in obese patients to appropriately diagnose, treat complications, and minimize morbidity.
Potential L1 transfer effects in explicit and implicit knowledge of articles in L2 English
Authors: Kim Myeong Hyeon , Ionin Tania 
Published: October 2022

Abstract
This study investigates how L1-Korean L2-English learners perform with regard to articles in both explicit and
implicit tasks. It also examines the role of L1-transfer from Korean demonstratives to English definites in L2 article production.
21 native English speakers and 27 adult intermediate L1-Korean L2-English learners were tested. The participants completed an
elicited imitation task (EIT, implicit) and a forced-choice task (FCT, explicit). In the EIT, participants repeated sentences with
and without articles, while stating whether the sentence matched the picture. In the FCT, participants chose the correct article
for each item. The same sentences were used in both tasks. The results showed that in the FCT, learners were target-like in
anaphoric contexts, supplying the, but very frequently overused a in non-anaphoric (bridging) contexts, suggesting that they
equate definiteness with previous-mention. In the EIT, learners were less target-like than native speakers, yet the patterns of
the two groups were similar. We consider possible explanations for the different results obtained in the two tasks.
Spatiotemporal distribution of size-fractioned phytoplankton in the Yalu River Estuary, China
Authors: Liu Yin , Song Lun , Song GuangJun , Wu JinHao , Wang Kun , Wang ZaoHui , Liu SuXuan 
Published: October 2022

ABSTRACT
The grain size structure of phytoplankton has great influence on shellfish culture. The present study aimed to assess the spatial and temporal variation in the phytoplankton community structure in the Yalu River Estuary and to explore the relationship between the phytoplankton community structure and various environmental parameters in 2020. High-throughput sequencing was used in this study. The results showed that nanophytoplankton, especially Karlodinium veneficum, dominated the estuary throughout the year. The biomass ratio of picophytoplankton, nanophytoplankton, and microphytoplankton were 20:63:17 in spring, 30:44:26 in summer, 1:38:61 in autumn, and 2:45:53 in winter, respectively. Meanwhile, Dinophyta had the greatest biomass throughout the year, followed by Bacillariophyta. On the spatial dimension (Station average), COD, T, SST had a positive impact on total phytoplankton communities, and Dep had a negative impact. In the time dimension (Monthly average), the environmental factor that significantly controlled the phytoplankton community structure were NO2 and SST.
Application of machine learning to explore the genomic prediction accuracy of fall dormancy in autotetraploid alfalfa
Authors: Zhang Fan , Kang Junmei , Long Ruicai , Li Mingna , Sun Yan , He Fei , Jiang Xueqian , Yang Changfu , Yang Xijiang , Kong Jie , Wang Yiwen , Wang Zhen , Zhang Zhiwu , Yang Qingchuan 
Published: October 2022

Abstract
Fall dormancy (FD) is an essential trait to overcome winter damage and for alfalfa (Medicago sativa) cultivar selection. The plant regrowth height after autumn clipping is an indirect way to evaluate FD. Transcriptomics, proteomics, and quantitative trait locus mapping have revealed crucial genes correlated with FD; however, these genes cannot predict alfalfa FD very well. Here, we conducted genomic prediction of FD using whole-genome SNP markers based on machine learning-related methods, including support vector machine (SVM) regression, and regularization-related methods, such as Lasso and ridge regression. The results showed that using SVM regression with linear kernel and the top 3000 genome-wide association study (GWAS)-associated markers achieved the highest prediction accuracy for FD of 64.1%. For plant regrowth height, the prediction accuracy was 59.0% using the 3000 GWAS-associated markers and the SVM linear model. This was better than the results using whole-genome markers (25.0%). Therefore, the method we explored for alfalfa FD prediction outperformed the other models, such as Lasso and ElasticNet. The study suggests the feasibility of using machine learning to predict FD with GWAS-associated markers, and the GWAS-associated markers combined with machine learning would benefit FD-related traits as well. Application of the methodology may provide potential targets for FD selection, which would accelerate genetic research and molecular breeding of alfalfa with optimized FD.
Incidental discovery of desmoid-type fibromatosis encapsulating granular cell tumor in a neck mass
Authors: Qureshi Abid , Andrade Roberto , Saavedra Jonathan , Xiao Philip , Asarian Armand 
Published: October 2022

Abstract
Multiple primary cancers are defined as primary malignant tumors of different histological origins in one person. Desmoid-type fibromatosis (DF) is an extremely rare, locally aggressive, connective tissue malignancy that can be rooted anywhere in the body with the most common sites being thoracic wall and extremities. In contrast, granular cell tumors are rare neoplasms derived from Schwann cells commonly found in the oral cavity, skin and gastrointestinal tract. Moreover, diagnosing a patient with two primary cell tumors has become more common and the challenge of treatment becomes the focus in clinical situations. However, findings of a mass containing DF encapsulated by a granular cell tumor. Currently, there are no established guidelines for this rare condition. This case report serves to raise awareness of these two uncommon primary tumors emerging in an idiosyncratic nature.
A Healthcare-Associated Infection With Monkeypox Virus of a Healthcare Worker During the 2022 Outbreak
Authors: Le Pluart Diane , Ruyer-Thompson Mirabelle , Ferré Valentine Marie , Mailhe Morgane , Descamps Diane , Bouscarat Fabrice , Lescure François-Xavier , Lucet Jean-Christophe , Yazdanpanah Yazdan , Ghosn Jade 
Published: October 2022

Abstract
This article describes a case of healthcare-associated monkeypox infection in France during the 2022 outbreak. A female medical resident accidently pricked herself with a soiled subcutaneous needle used to harvest a vesicle of a patient infected by monkeypox virus and developed 4 days later a unique skin lesion, positive for monkeypox virus.
001 Egyptian consensus-based recommendations for the diagnosis and targeted management of Kawasaki disease. An initiative by the Egyptian College of Pediatric Rheumatology
Authors: El Miedany Y , Lotfy H , Salah S , Abu-Zaid M. H , Mohamed S. S , Esam Maher S , El Gaafary M , Abdulhady H , Hassan W. A , Mortada M , Amer Y , Osman N. S , Medhat B. M , Farag Y , Eissa M , Radwan A , Nasef S. I , Elkaraly N. E , El-Shanawany Amira T , El Mikkawy D , Mosa D. M , El Deriny G , Fouad N. A , Tabra S. A 
Published: October 2022

Abstract

Background
Kawasaki disease (kDa) is a self-limiting acute vasculitis that affects small and medium-sized vessels, and is the most common cause of acquired heart disease in children. It is also an important reason for long-term cardiac disease into adulthood. Rapid diagnosis and management of kDa is challenging due to the heterogeneity of the disease, yet is vital for improving outcome. To date, there are no Egyptian nationally agreed, evidence-based guidelines concerning the diagnosis and management of kDa in children. Consequently, treatment regimens vary broadly.

Objectives
To develop a consensus, evidence-based recommendations for the diagnosis, evaluation and management of children living with kDa.

Methods
This study was carried out to achieve an Egyptian expert consensus on a management strategy for kDa using Delphi technique. A multistep process strategy was adopted, which started by developing 16 key clinical questions by scientific committee according to the Patient/Population, Intervention, Comparison, Outcomes and Time (PICOT) approach. The core leadership team identified clinicians and researchers with expertise in pediatric rheumatology all over Egypt. An evidence-based, systematic, literature review was conducted to compile evidence for the kDa management. Delphi process was implemented (3-rounds) to reach a consensus.

Results
Twenty-five expert panel participated in the 3 rounds with response rate 100%. A total of 21 recommendations, categorized into 9 domains (Definition, disease activity, predicting the development of coronary disease, assessment and monitoring (lab, imaging), treatment (acute and after acute attack), management of resistant cases, management of complications (cardiac complications, MAS and arthritis), vaccination and long term follow up. The Agreement with the recommendations (rank 7–9) ranged from 83.6–95.7%. The Consensus was reached (i.e. ≥75% of respondents strongly agreed or agreed) on all the clinical standards. Algorithm for management has also been developed.

Conclusion
This was an expert, consensus recommendations for the diagnosis and treatment of kDa, based on best available evidence and expert opinion. The recommendations provided a management approach based on easy-to-use algorithm and with the support of complementary tests.

The implication to policy, practice, research and advocacy
to provide updated recommendations for better management of kDa.
11 Evaluation of doctors’ knowledge (excluding rheumatologists and pediatricians) of juvenile idiopathic arthritis
Authors: Tbini Houssem , Jemmali Samia , Boussaid Soumaya , Ammou Ahlem Ben , Rahmouni Safa , Rekik Sonia , Zouaoui Khaoula , Sahli Hela , Elleuch Mohammed 
Published: October 2022

Abstract

Background
Juvenile idiopathic arthritis (JIA) is the most common pediatric inflammatory arthritis. However, this disease is not fully understood by all practitioners.

Objectives
The objective of this survey is to assess the level of knowledge and attitudes of doctors excluding rheumatologists and pediatricians on the management of JIA.

Methods
In this cross-sectional descriptive study, an anonymous questionnaire composed of 20 questions, designed with the Google-Forms software, was sent via social networks to doctors from different specialties (excluding rheumatologists and pediatricians) and to interns and residents of the University Hospitals of Tunis.

Results
A total of 100 physicians responded to the questionnaire (61 women and 39 men). The mean age was 31.01 ± 5.64 [24–51] years. Fifty-seven percent of the participants were in training, 27% worked in public hospitals and 16% in private clinics. Most participants were general practitioners (32%), followed by ophthalmologists (9%), gynecologists (7%), and internists (5%). the mean length of service was 4.99 ± 4.5 [0–22] years. Thirty-six participants affirmed they have been confronted with patients with JIA. Twenty percent of participants believed they have knowledge about JIA. Among them, 25% believed they have sufficient knowledge, the others had superficial knowledge. Thirty-four percent of participants knew the definition of the disease according to the age, 17% knew its frequency and 18% had an idea about its various sub forms. The most frequent sub form was known only by 32 participants.
Regarding the complications of JIA, only 25% of the participants thought of the macrophage activation syndrome in case of deterioration of the general state, fever, and pancytopenia. In addition, 44% of participants knew that JIA can be complicated by ocular involvement.
Concerning the presence of rheumatoid factors and anti-nuclear antibodies during JIA, 64% and 60% respectively answered that their presence was not necessary.
Concerning the care of JIA, 64% of participants referred these patients to rheumatologists, 31% to a pediatrician, and 5% took care of them themselves.
The interest of methotrexate and biological treatments were known by 48% of the participants. However, 37% of participants had no idea of the therapeutic management of JIA.
Concerning the prognosis, only 25% of the participants know the sub forms of bad prognosis. However, 48% had no idea about the prognosis of the disease.

Conclusion
The level of knowledge of doctors on JIA is low to average. Training for physicians on this potentially serious disease is needed.
15 Fertility in juvenile idiopathic arthritis
Authors: Ammou Ahlem Ben , Rahmouni Safa , Boussaid Soumaya , Tbini Houssem , Jemmali Samia , Rekik Sonia , Zouaoui Khaoula , Sahli Hela , Elleuch Mohammed 
Published: October 2022

Abstract

Background
Juvenile idiopathic arthritis (JIA) is a chronic rheumatic disease seen in children below 16 years of age. However, it may persist into adulthood. The damage caused by the disease can influence the sex life and fertility of adults with long-standing JIA.

Objectives
To study the fertility of patients with JIA.

Methods
We conducted a retrospective study including adults with long-standing JIA according to the International League of Associations for Rheumatology (ILAR) criteria.
A detailed questionnaire was completed for each participant by interviewing them as well as by information obtained from their medical records. We identified among the adult patients, those who are married, their age at marriage, the number of gestation and parity, the age of the first child, miscarriages, and occurrence of menopause.

Results
A total of 29 Patients were enrolled, the M/F sex ratio was 0.71. The mean age was 35.69 ± 11.72 [18–61] years. The mean age of disease onset was 11.10 ± 4.25 [2–16] years. The average disease duration was 24.48 ± 12.76 [1–47] years. The mean BMI was 21.20 ± 4.89 [14.17–27.55] kg/m², 36.9% of patient had a BMI ≥ 25 kg/m². Fourteen patients had hip involvement.
Seven patients (6 women, 1 man) were married (24%). The mean age at marriage was 23.75 ± 7.5 [20–35] years. The mean delay between disease onset and marriage was 10 ± 6.68 [6–20] years. Six patient had children, the mean number of gestation and parity were 2.56 ± 2.88 [0–6] and 2 ± 2.29 [0–6] respectively. Miscarriage was noted in 2 patients. Menopause was observed in 3 patients, the mean age at menopause was 46.67 ± 1.53 [45–48] years.

Conclusion
Most of our patients were not married. This reflects the significant impact of the disease on the social and sexual life of JIA patients at adulthood.
17 Anemia in juvenile idiopathic arthritis: analysis of associated factors
Authors: Tbini Houssem , Rahmouni Safa , Boussaid Soumaya , Ammou Ahlem Ben , Jemmali Samia , Rekik Sonia , Zouaoui Khaoula , Sahli Hela , Elleuch Mohammed 
Published: October 2022

Abstract

Background
Anaemia is the most frequent hematological disorder in chronic inflammatory rheumatic disease. Few studies have focused on this impairment in juvenile idiopathic arthritis (JIA).

Objectives
To identify the factors associated with anaemia in JIA.

Methods
We conducted a retrospective study including adults with long-standing JIA according to the International League of Associations for Rheumatology (ILAR) criteria over a period of 28 years (1994–2022). Demographic, clinical, biological, and radiographic data were collected. These parameters were compared according to the presence or absence of anaemia.

Results
Seventeen women and 12 men were enrolled. The mean age was 35.69 ± 11.72 [18–61] years. The mean age of disease onset was 11.10 ± 4.25 [2–16] years. The average diagnostic delay was 52.96 ± 95.97 [0–336] months. The average disease duration was 24.48 ± 12.76 [1–47] years.
The polyarticular form was the most frequent (n = 16). Rheumatoid factor, ACPA and antinuclear antibodies were present in 41.4%, 24.1% and 17.2% of cases respectively. Mean CRP values were 42.74 ± 63.37 [2–218] mg/l, a biological inflammatory syndrome was present in 19 cases.
NSAIDs, corticosteroids and methotrexate were used in 62.1% (n = 18), 69% (n = 20) and 79.3% (n = 23) respectively.
Anaemia was noted in 69% (n = 20) of cases, it was hypochromic in 8 cases and microcytic in 11 cases. The mean haemoglobin value was 11.31 2.10 [6.5–15] g/dl.
Anaemia was associated with the following parameters in our study: female sex (88.2% vs 41.7%; p = 0.008), absence of anti-nuclear antibodies (76.9% vs 20%; p = 0.026) and corticosteroid therapy (85% vs 33.3%; p = 0.005). However, the comparison of patients according to the presence of anaemia did not show any significant difference for these parameters: age, age at onset, diagnostic delay, duration of symptoms, extra-articular manifestations, CRP value, presence of biological inflammatory syndrome, rheumatoid factor, ACPA, erosive nature and treatment (NSAIDs and methotrexate).

Conclusion
Anaemia is common in JIA. Its treatment is part of the overall management of the disease.
20 Does hip involvement affect foot and ankle in juvenile idiopathic arthritis?
Authors: Myriam Moalla , Hanene Ferjani , Wafa Triki , Dorra Ben Nessib , Kaouther Maatallah , Dhia Kaffel , Wafa Hamdi 
Published: October 2022

Abstract

Background
Although ankle and foot involvements are common in juvenile idiopathic arthritis (JIA), they are often neglected. Hip involvement, also common in JIA, may affect these joints by creating a chronic imbalance of the musculoskeletal system. However, no studies have been published on this subject.

Objective
We aimed to describe ankle and foot impairment in a cohort of patients with JIA and to study the correlation between these impairments and the presence of hip arthritis.

Methods
A monocentric cross-sectional study was conducted including JIA patients fulfilling the 2001 ILAR criteria. Patients with congenital malformation of the ankle or foot or with any other foot impairment due to a disease other than JIA were not included. Foot examination was performed on bare feet both in supine and standing position. We completed with an analysis of footprint with a podoscope and shoes examination. Patients were divided in two groups depending on the presence or the absence of hip arthritis on pelvis X-ray, hip ultrasound or hip magnetic resonance imaging.

Results
We included 35 patients (M/F = 15/20). Hip arthritis was noted in 45.7%. Oligoarticular (43.8%) and enthesitis-related arthritis (25%) were the most frequent form of JIA. Functional complaints related to foot and ankle were reported in 34.3% of cases. The pain was the most frequent symptom (91%), mainly in the hindfoot and ankle (50%). Foot pain was more frequently encountered in the absence of hip arthritis (52%, vs 31.2% in presence of hip arthritis). Physical examination revealed limitation of the talocrural joint in 20% of cases and feet tenosynovitis in 14.3% of cases. Achille tendon enthesitis was found in 8.6% of patients. These abnormalities were more prevalent in the absence of hip arthritis. Half of the patients had hindfoot deviation dominated by hindfoot varus (22.9%). In the group with hip arthritis, a hallux valgus was found in 14.3%, a supraductus of the 2nd toe, and claw toe in one case each. An anomaly of the footprint was noted in 28 patients, including 11 in the group with hip involvement: 7 cases of cavus foot and 4 cases of flat foot. There were no correlations between foot or ankle anomalies with hip impairment apart from an association of flat foot with the absence of coxitis, and a leg length discrepancy more important in the group with hip arthritis.

Conclusions
Our study confirms the frequency of foot and ankle involvement as well as hip arthritis during JIA, hence the importance of their systematic screening even in asymptomatic children. Larger-scale studies would be necessary to evaluate with more precision the relation that there could be between hip and foot impairment.