bluuebunny/crossref_metadata_2025_split huggingface dataset:
Self-critical thinking mediates the relationship between perfectionism and perceived stress in undergraduate students: a longitudinal study
Authors: Stevenson Jodie , Akram Umair 
Published: March 2022

Abstract
The present study examined the concurrent and longitudinal relationships between multidimensional perfectionism, perceived stress, and self-critical thinking in a sample of UK university students. Specifically, to determine whether self-critical thinking at baseline mediated the longitudinal relationship between baseline perfectionism and future stress at follow-up. At baseline, N=220 students completed measures of multidimensional perfectionism, perceived stress, and self-critical thinking, whereas N=84 completed the same measures at follow-up. Socially prescribed, and self-oriented perfectionism were related to increased stress, self-hatred, and self-inadequacy at baseline. Longitudinal analysis revealed that baseline self-oriented and socially prescribed perfectionism predicted increased reports of stress and self-critical thinking three weeks later at follow-up. More crucially, multiple mediation analysis found self-hatred and inadequacy at baseline mediated the longitudinal relationship between baseline perfectionism and perceived stress at follow-up. Perfectionistic and self-critical thinking appears to accentuate the experience of perceived stress in the university student population. Student-based interventions to reduce self-critical thinking may prove beneficial in preventing the onset of perceived stress.
Extracellular vesicle formation mediated by local phosphatidylserine exposure promotes efficient cell extrusion
Authors: Kira Akihito , Tatsutomi Ichiko , Saito Keisuke , Murata Machiko , Hattori Izumi , Kajita Haruna , Muraki Naoko , Oda Yukako , Satoh Saya , Tsukamoto Yuta , Kimura Seisuke , Kato Hiroki , Hirashima Tsuyoshi , Kawane Kohki 
Published: March 2022

Abstract
Cell extrusion is a universal mode of cell removal from tissues, and it plays an important role in regulating cell numbers and eliminating unwanted cells, such as apoptotic, unfit, or cancerous. During this process, cells delaminate from the cell layer, however, the underlying mechanisms remain to be elucidated. Here, we report a conserved execution mechanism of cell extrusion. We found extracellular vesicle (EV) formation in extruding cells at a site opposite to the extrusion direction. Particularly, we found that a lipid-scramblase‒mediated local exposure of phosphatidylserine is responsible for EV formation and is crucial for executing cell extrusion, while inhibition of this process disrupted prompt cell delamination and tissue homeostasis. Furthermore, we revealed that the EV formation is governed by the mechanism in microvesicle formation, while the EVs have some hallmarks of apoptotic body. Finally, we illustrated the role of EV formation as promoting the neighboring cells’ invasion resulting in the execution of cell extrusion by experimental and mathematical modeling analysis. Taken together, this study provides the insights that membrane dynamics plays a crucial role behind the cell exit from the tissue by connecting the actions of extruding cell and the neighboring cells.
Integrase Strand Transfer Inhibitor (INSTI) Genotypic Resistance Analysis
in Treatment-Naive, INSTI Free Antiretroviral-Experienced and
INSTI-Experienced Turkish Patients Infected with HIV-1
Authors: Sayan Murat , Yildirim Figen Sarigul , Akhan Sila , Karaoglan Ilkay , Akalin Halis 
Published: March 2022

Background and Objective:
Integrase strand transfer inhibitors (INSTIs) are currently
the standard of practice for first-line HIV therapy for most patients. We evaluated the mutations associated
with INSTI resistance in naive HIV-1 infected patients and treated them with antiretrovirals
(ART).

Methods:
The study, conducted in the 2018 - 2020 period, included 50 ART-naïve patients, 69 INSTI
free ART-experienced patients, and 82 INSTI-experienced patients. INSTI resistance mutations
were interpreted using the Stanford University HIVdb Program algorithm.

Results:
INSTI resistance was not detected in ART naïve patients. At least one INSTI resistance
mutation was detected in 10% of the INSTI-free patients and 29% of the INSTI-treated patients.
Major INSTI-mutations E138K, Y143R, S147G, Q148R, N155H, and E157Q were found in raltegravir.
Additional mutations, E92Q, E138K, G140A, S147G, and Q148R were found in
elvitegravir; E192Q, E138K/T, G140A/S, S147G, Q148H/R, N155H, E157Q were found in dolutegravir
(DTG) experienced patients. According to all drug classes, drug resistance mutation prevalences
were determined at the rate of 60%, 46%, and 46% in the RAL, EVG, and DTG groups, respectively.

Conclusion:
Our findings provide data for treatment and resistance management of INSTIs and
may provide feedback for INSTIs resistance surveillance consensus-building efforts. In viral rebound
under INSTI treatment, INSTI-resistant mutations follow typical INSTI resistance pathways
and high resistance rates. INSTI resistance genotypic analysis should be considered before any
DTG-based regimes can be initiated in the future, and reduced DTG susceptibility should be carefully
monitored and investigated.
Multimodalidad como base para la creación de portafolios electrónicos en el contexto universitario
Authors: Rodríguez Mateo Arnaldo , León Rodríguez Giraldo de la Caridad 
Published: March 2022

Los portafolios digitales o e-portafolios, según diferentes autores, cumplen con tres funciones principales: almacenamiento, espacio de trabajo y vitrina. Como almacenamiento electrónico muestran documentos digitales, permiten compartir los proyectos o tareas, así como incluir informes de progreso y recursos sobre el aprendizaje para usar dentro o fuera del aula. Como espacio de trabajo, permiten a los alumnos actualizar, editar o proteger los artefactos digitales que se almacenan en un espacio virtual. Como vitrina, permiten exhibir el talento y los trabajos de los estudiantes, en cualquier lugar y momento, como preparación para su futura búsqueda de empleo. El presente trabajo tiene como objetivo presentar los resultados de una investigación bibliográfica preliminar y de dos diagnósticos desarrollados con vistas a elaborar un modelo con carácter multimodal que permita vincular los e-portafolios estudiantiles con el proceso de meta cognición (conceptualización, presentación y creación). Esto, a través de un esquema de diseño visual del portafolio electrónico mejorando sus recursos tipográficos, diseño de sus componentes y empleo de la hipertextualidad como estrategia cognitiva. La propuesta de esquema de construcción del portafolio digital ha sido evaluado y validado por expertos contribuyendo a mejorar el proceso enseñanza – aprendizaje, sobre todo en ambiente mixto o totalmente online.
Costos de no calidad asociados a infección de sitio operatorio en poscesareadas, Colombia, 2020.
Authors: Lora Solmaira , Ocampo Rivero Mónica , Espitia Cabralez Enalbis Esther 
Published: March 2022

Objetivo: Determinar los costos de no calidad en una institución de salud de Colombia, en pacientes postquirúrgicas de cesárea que presentaron Infección en Sitio Operatorio (ISO). Materiales y métodos: Estudio descriptivo transversal, que estima los costos de no calidad de cuatro pacientes postquirúrgicas de cesárea que reingresaron a la institución por presentar infección en sitio quirúrgico. Los datos fueron proporcionados por el departamento de Calidad y Seguridad del Paciente, con base en los eventos adversos reportados en el período comprendido en el primer semestre del año 2020. Los costos hospitalarios, fueron clasificados de la siguiente manera: asistenciales, administrativas y de otro tipo, se calcularon desde que la paciente reingresó hasta que fue dada de alta. Resultados: El 100% de las mujeres intervenidas tienen edades que oscilan entre los 25 y 30 años, con nivel socioeconómico de estrato 1 (89.5%); promedio de 5 días de estancia hospitalaria al reingreso; los costos del reingreso hospitalario son mayores con un promedio de $304.943 (IC, 149.672 - $460.215); la realización de la cesárea muestra un costo promedio de $184.918. Con relación a los costos asistenciales, el mayor promedio de la realización de la cesárea se encuentra en las consultas con $527.224, seguido de los gastos quirúrgicos con un promedio de $415.395 y de recurso humano con $298.236; mientras que para el reingreso, el mayor costo se presentó en recursos humanos con $1.133.298 en promedio, seguido de las consultas con $645.681 y los costos de habitación con $439.613. Conclusión: Los costos de no calidad afecta el presupuesto de la institución, colocando en riesgo la estabilidad financiera y la imagen corporativa. Es importante realizar seguimiento a la adherencia de los protocolos, guías de atención, y paquetes instruccionales de buenas prácticas.
Marcadores moleculares asociados a resistencia antimalárica en la región Caribe Colombiana: Estado del conocimiento
Authors: De la Cruz Fernando Rafael , Acuña Luis Mariano , Lagares Alfredo Manuel , Varela Lourdes Luz , Mendoza Dary Luz 
Published: March 2022

Objetivo: Revisar el estado del conocimiento de marcadores moleculares asociados a resistencia antimalárica en la región Caribe. Materiales y métodos: Se realizó una revisión sistemática de literatura científica sobre marcadores moleculares asociados a resistencia antimalárica en la región Caribe. La búsqueda se hizo en bases de datos utilizando estos criterios: “PCR” “Plasmodium falciparum” “Plasmodium vivax” “Resistencia” “Antimalárica” “genes” en los departamentos de: Atlántico, Bolívar, Cesar, La Guajira, Magdalena, Sucre y Archipiélago de San Andrés, Providencia y Santa Catalina entre 2000-2020. Resultados: Se incluyeron cuatro estudios en los departamentos de Sucre (2005), Magdalena (2010) y Bolívar (2013 y 2017), se identificaron las variantes genéticas S108N en pfdhfr y A437G en pfdhps de P. falciparum en Sucre y Bolívar respectivamente, K76T en pfcrt de P.falciparum en Magdalena y F1076L - Y976F de pvmrd-1 en P.vivax de Bolívar. Los estudios del departamento de Bolívar que emplearon la secuenciación Sanger identificaron las variantes genéticas S436F- K540E en pfdhps y T958M en pvmdr-1. Conclusiones: Existen pocos estudios de marcadores moleculares asociados a resistencia antimalárica en la región, por lo que estamos lejos de definir el perfil de resistencia antimalárica en el Caribe colombiano. Es necesario hacer vigilancia molecular empleando tecnologías de vanguardia.
Incentive Distribution of Specialist Doctors in Government General Hospital
Authors: Susyanty Andi Leny , Hendarwan Harimat , Su'udi Amir 
Published: March 2022

Abstract
Maintaining and fulfilling the needs of specialist doctors in government public hospitals is still a challenge. Government general hospitals have not been able to meet the minimum standard for specialist doctors. The distribution of personnel and the incentives received by specialist doctors varies between regions. This study aims to provide recommendations related to policies to meet the needs of specialist doctors at government general hospitals. This cross-sectional research study was conducted in May - December 2017 in 19 hospitals in 18 districts/cities. A total of 134 specialist doctors and dental specialists were respondents in this study. The fulfillment of non-financial incentives for specialist doctors, 28.4% lived in official homes, 41.8% received official vehicles and 73.1% were facilitated to attend seminars/education and training. Fulfillment of financial incentives shows that 73.1% of their income is sufficient for the family’s needs for 1 month and 63.5% can save. Further east, the incentives received by specialist doctors are greater. The combined capacity of central and local budgets can be optimized to provide adequate and equitable incentives to retain specialist doctors in government hospitals, especially in less desirable areas and with limited budgets.
Keywords: adequacy, disparity, incentive
Abstrak
Keberadaan dan kecukupan dokter spesialis di rumah sakit umum pemerintah masih menjadi kendala. Masih banyak rumah sakit yang belum memenuhi standar minimal dokter spesialis di rumah sakit dan masih adanya disparitas distribusi tenaga dan insentif dokter spesialis di tiap daerah. Penelitian ini bertujuan untuk menyediakan rekomendasi kebijakan terkait pemenuhan kebutuhan dokter spesialis dari aspek penyediaan insentif bagi dokter. Penelitian ini dilakukan secara cross-sectional dan dilaksanakan pada bulan Mei - Desember 2017 di 19 RS di 18 kabupaten / kota. Sebanyak 134 dokter spesialis dan dokter gigi spesialis yang menjadi responden penelitian ini. Sebanyak 28,4% tinggal di rumah layanan yang disediakan, 73,1% dari pendapatannya mencukupi kebutuhan keluarga selama 1 bulan, 63,5% dapat menabung, 41,8% dapat kendaraan, 73,1% telah difasilitasi untuk mengikuti seminar / pendidikan dan pelatihan. Semakin ke timur, insentif yang diterima dokter spesialis semakin besar. Kombinasi kemampuan anggaran pusat dan daerah dapat dioptimalkan untuk memberikan insentif yang memadai dan merata untuk mempertahankan dokter spesialis di rumah sakit pemerintah, terutama di daerah yang tidak diminati dan dengan kendala anggaran.
Kata kunci: kecukupan, disparitas, insentif
PRESERVATION BY SOCIALIZING THE BENEFITS AND NUTRITIONAL CONTENT OF SIMALUNGUN TYPICAL SAUCES TO WOMEN’S ORGANIZATION OF SIMALUNGUN CENTRAL BUREAU OF STATISTICS
Authors: Damanik Marini 
Published: March 2022

Preservation of Simalungun's typical sauce to the women’s organization of Simalungun Central Bureau of Statistics by the Medan State University Research and Service Center, namely tinuktuk sauce, have been carried out by socializing the benefits and contents of which have been carried out online. Preserving this tinuktuk sauce as a form of community service has already been done by the Universita Negeri Medan community research and service center. It is implemented by socializing the benefits and nutritional content of tinuktuk. In the webinar, not only the introduction of the Simalungun tinuktuk sauce, but also the nutritional content and benefits of the tinuktuk sauce were also socialized. This is also related to the importance of nutritional needs to increase body immunity during the COVID-19 period. In the process of socializing efforts to preserve the benefits and nutritional content of Simalungun's special sauce, there was a significant difference in result between the pre-test and post-test, namely in the pre-test 43% and post-test 84%, and this indicates that participants know the benefits and nutritional content of Simalungun’s typical tinuktuk sauce. This community service activity went smoothly because the participant already knew about the nutritional content and benefits of Simalungun’s typical tinuktuk sauce and it’s hoped that the tinuktuk sauce can be preserved.
Lector in ffabla. Estructuras del Setenario de Alfonso X el Sabio (I)
Authors: Puigdengolas Johan 
Published: March 2022

El siguiente trabajo se centra en el papel de la lectura en el proceso de desciframiento y de comprensión del Setenario de Alfonso X. A partir de varios enfoques, se analizarán las especificidades del procedimiento de codificación que es el “setenario” así como sus significaciones para el lector.
“Ninguno non puede fazer conde sy le el rrey non le faze”. La reescritura del Poema de Fernán González en la Estoria de España como manifestación de la ideología de los cronistas alfonsíes
Authors: Lacomba Marta 
Published: March 2022

En términos generales, la Estoria de España sigue con señalada fidelidad el texto del Poema de Fernán González. Por ello, los puntos de ruptura resultan reveladores de las divergencias ideológicas entre el monje de Arlanza y los cronistas de Alfonso X, cuyo trabajo de reescritura se examina aquí.
Determinants of collaborative hybrid organisations in the construction industry of the Republic of Croatia
Authors: Moćan Dinko Stanković 
Published: March 2022

Abstract
Given that the literature indicates a lack of cooperation and outdated supply chains in construction, which are based mainly on short-term relationships and coordination through price, hybrid organisations between major contractors and subcontractors in construction in Croatia were investigated. The study aimed to define the determinants of collaborative hybrid organisations in the construction industry of the Republic of Croatia, and to investigate the motives and obstacles to their emergence as well as their differences with respect to control variables. Determinants, motives and obstacles are defined by detailed secondary research of theoretical works, while the differences between them are determined by the results of variance analysis. The research indicates that construction companies do not organise their upstream parts of supply chains only on the authority and position of power, but also use other management mechanisms, especially collaboration based on trust.
Aktifitas Perdagangan Lokal di Kepualuan Maluku Abad 15 M - 19 M, Tinjauan Awal Berdasarkan Data Keramik Asing dan Komoditas Lokal
Authors: Handoko Wuri 
Published: March 2022

Famous Moluccas Archipelago as its heaven is mace, this matter cause commers activity in this archipelago region like fun, since early recognizing of commerce till a period to its top when Arab merchant, Chinese, and Europe enter this region, noise Avtivities commerce, not even unrightiously is foreign but also commerce in internal scope (local). Local Activities Commerce depict transfer noise (intersection) commodity of among commercial area which is one with other commercial area in region of coastal area in Moluccas archipelago scope. Local trade also depict activities exchange commodity of among coastal area and hinterland. In archaeology study, foreign ceramic data can play role to depict that matter. This matter remember foreign finding ceramic is not even found in seaboard of found also in sies archaeology in this area hinterland. This study is goods transfer of between seaboard with hinterland can be tracked.
Analisis Fungsi Sintaksis dan Nilai di Dalam Pepatah Bahasa Indonesia
Authors: Br Ginting Epril Linia , Madia I Made , Mas Triadnyani I G.A.A. 
Published: March 2022

This study discusses syntactic functions, cultural values and national character in Indonesian proverbs. Problems discussed in study (1) what is form of Indonesian proverb. (2) what are values (education in the culture and character of nation) contained in the Indonesian proverb (3) what are aspects of social meaning of the Indonesian proverb. Method of data collection in this study is method of listening, technique used is technique of note taking. theories used are syntax and ethnolinguistics. Data analysis carried out was concluded from number of clauses in Indonesian proverbs grouped into single sentence proverbs and complex sentence proverbs. Based on implementation of ethnolinguistic theory referring to Permendiknas 2010 resulted in eighteen values of cultural education and national character. social aspect Indonesian proverb is divided into two parts, (1) reflection of society contained in form of advice in proverb and (2) social function in form of moral values contained in proverb.
Pengerasan Permukaan Baja Perkakas HSS M41 dengan Teknik Pelapisan Metal Spray
Authors: P Tarigan , Juwita L 
Published: March 2022

Intermetallic compound Fe-AL has good strength and hardness properties. Those properties were required Io improve the wear resistance of component which its application always contact with another part like cutting tool in machining processes. This experiment was carried out to improve the wear resistance of metal, which in this case is high-speed steel (HSS M41). This preliminary experiment was focused on to form the Intermetallic compound Fe-Al layer in the surface Of the steel, This layer was obtained by metal spray technique in which Al-Si spray to the surface of base metal HSS M41 and then heat-treated at 850oC, The holding time of heat treatment for 4 hours, 6 hours and 8 hours respectively was used, Experimental results showed holding time of heat treatment process was influenced to forming the intermetallic layer, thickness and hardness was specimen with heat-treated at 850 OC and holding time 8 hours exhibit the maximum hardness of 1120 HV and also increase the lifetime from 1.84 days to 14.125 days. The thickness of intermetallic layer was 0.81 mm.
Analisis Tingkat Kesehatan Bank (Metode RBBR): Perbandingan Kelompok Bank Umum dan BUKU
Authors: Yulianti Vania , Christianti Ari 
Published: March 2022

ABSTRAK Tujuan penelitian – Penelitian ini bertujuan untuk mengukur dan membandingkan tingkat kesehatan bank antara kelompok bank umum dan Bank Umum Berdasarkan Kegiatan Usaha (BUKU). Desain/Metodologi/Pendekatan –Penelitian ini menggunakan metode RBBR (Risk Based Bank Rating) untuk menilai tingkat kesehatan bank dengan menggunakan faktor Risk Profile, Good Corporate Governance, Earnings dan Capital (RGEC) Temuan – Hasil penelitian menunjukkan bahwa faktor GCG dan faktor Risk Profile menjadi faktor yang paling penting dalam mencapai bank yang sehat. Hal ini terbukti dari bank yang melaksanakan GCG dan manajemen risiko yang baik memiliki kinerja yang baik dan berdampak pada pencapaian kesehatan bank yang baik pula. Keterbatasan penelitian – Penelitian ini memiliki keterbatasan hanya menggunakan satu rasio keuangan untuk masing-masing faktor Risk Profile, Good Corporate Governance, Earnings dan Capital (RGEC). Selain itu, penelitian ini hanya menilai kesehatan bank per faktor, dikarenakan belum ada peringkat komposit gabungan dari semua faktor yang ada dalam RGEC sekaligus. Originality/value – Penelitian ini mencoba untuk membandingkan tingkat kesehatan bank berdasarkan kelompok bank umum dan BUKU untuk mengetahui bank yang memiliki tingkat kesehatan terbaik berdasarkan faktor-faktor yang ada dalam RGEC. Keywords : Risk Profile, Good Corporate Governance, Earnings dan Capital.
Pengaruh Ukuran Perusahaan Terhadap Nilai Perusahaan dengan Struktur Modal sebagai Variabel Intervening
Authors: Jannah Siti Miftahul 
Published: March 2022

ABSTRAK Tujuan penelitian – Hal yang perlu diperhatikan dalam berinvestasi salah satunya dengan melihat ukuran perusahaan dan pengelolaan modalnya untuk menunjang harga saham yang menunjukkan nilai dari perusahaan tersebut. Untuk itu, penting untuk mengetahui ukuran perusahaan dan struktur modal dalam sebuah perusahaan agar invostor mengetahui nilai perusahaan. Desain/Metodologi/Pendekatan – Teknik pengambilan sampel menggunakan purposive sampling dengan objek pada sub sektor industry barang konsumsi dan sub sektor pertambangan yang terdaftar di BEI tahun 2018-2020. Dengan jumlah populasi sebesar 119 perusahan dan sampel sebesar 92 perusahaan dengan menggunakan analisis jalur (path analysis). Temuan – Ukuran perusahaan berpengaruh negative signifikan terhadap nilai perusahaan.Ukuran perusahaan berpengaruh negative dan tidak signifikan terhadap struktur modal.Struktur modal berpengaruh positif terhadap nilai perusahaan. dan struktur modal tidak dapat menjadi variabel intervening pengaruh dari ukuran perusahaan terhadap nilai perusahaan Keterbatasan penelitian – Penelitian ini hanya menggunakan objek pada perusahaan dengan sub sektor pertambangan dan sub sektor industry barang konsumsi. Selain itu, penelitian ini menggunakan satu indikator penilaian pada setiap variabel. Originality/value – Penelitian ini diharapkan mampu memberikan manfaat dalam bidang keuangan dalam sebuah perusahaan dan penilaian terhadap ukuran, nilai dan modal perusahaan. Keywords : Ukuran Perusahaan, Struktur Modal, Nilai Perusahaan.