bluuebunny/crossref_metadata_2025_split huggingface dataset:
Caregiver Perspectives on Underutilization of WIC: A Qualitative Study
Authors: Gago Cristina M. , Wynne Jhordan O. , Moore Maggie J. , Cantu-Aldana Alejandra , Vercammen Kelsey , Zatz Laura Y. , May Kelley , Andrade Tina , Mendoza Terri , Stone Sarah L. , Mattei Josiemer , Davison Kirsten K. , Rimm Eric B. , Colchamiro Rachel , Kenney Erica L. 
Published: January 2022

OBJECTIVESThe Special Supplemental Nutrition Program for Women, Infants, and Children (WIC) is a federal program that improves the health of low-income women (pregnant and postpartum) and children up to 5 years of age in the United States. However, participation is suboptimal. We explored reasons for incomplete redemption of benefits and early dropout from WIC.METHODSIn 2020–2021, we conducted semistructured interviews to explore factors that influenced WIC program utilization among current WIC caregivers (n = 20) and caregivers choosing to leave while still eligible (n = 17) in Massachusetts. By using a deductive analytic approach, we developed a codebook grounded in the Consolidated Framework for Implementation Research.RESULTSThemes across both current and early-leaving participants included positive feelings about social support from the WIC clinic staff and savings offered through the food package. Participants described reduced satisfaction related to insufficient funds for fruits and vegetables, food benefits inflexibility, concerns about in-clinic health tests, and in-store item mislabeling. Participants described how electronic benefit transfer cards and smartphone apps eased the use of benefits and reduced stigma during shopping. Some participants attributed leaving early to a belief that they were taking benefits from others.CONCLUSIONSCurrent and early-leaving participants shared positive WIC experiences, but barriers to full participation exist. Food package modification may lead to improved redemption and retention, including increasing the cash value benefit for fruits and vegetables and diversifying food options. Research is needed regarding the misperception that participation means “taking” benefits away from someone else in need.
A landiolol alkalmazási lehetőségei a kardiológiai és intenzív terápiás ellátásban
Authors: Radics Péter , Kiss Boldizsár , Kovács Enikő , Pilecky Dávid , Ruzsa Zoltán , Straub Éva , Fejér Csaba , Gellér László , Merkely Béla , Zima Endre 
Published: January 2022

Összefoglaló. A landiolol intravénásan alkalmazandó, kifejezetten
cardioselectiv, gyors hatású és rövid felezési idejű béta-1-receptor-blokkoló,
mely elsősorban negatív chronotrop és inotrop hatással bír, vérnyomáscsökkentő
hatása elhanyagolható. Főleg hemodinamikailag instabil állapotú,
supraventricularis ritmuszavarban szenvedő betegek kamrafrekvenciájának
csökkentésére használható. Nagy esetszámú, randomizált vizsgálatok igazolták
hatékonyságát szívműtétek után jelentkező pitvarfibrilláció megelőzésében,
valamint súlyos akut szívelégtelenségben és szívműtétek posztoperatív szakában
jelentkező pitvari tachyarrhythmiák kezelésében. Ezek mellett kisebb vizsgálatok
alapján a használata biztonságosnak tűnik akut myocardialis infarctusban,
hatékony szeptikus állapotú, pitvarfibrillációban szenvedő betegek
kamrafrekvencia- és ritmuskontrolljára, valamint nem cardialis műtétek esetén a
pitvarfibrilláció prevenciójára és kezelésére. Sikerrel alkalmazható elektromos
vihar esetén is, és jól használható angiográfiás coronaria-CT-vizsgálat előtt az
optimális szívfrekvencia elérésére. A gyógyszer 2016 óta Európában, 2018 óta
Magyarországon is elérhető. Orv Hetil. 2022; 163(2): 53–62.
Summary. Landiolol is an intravenous, selective beta-1-receptor
blocking agent with rapid onset of action and ultra-short half-life that has a
predominant negative chronotropic and only mild negative inotropic effect
without significant reduction of blood pressure. Landiolol is indicated to
control the ventricular heart rate predominantly in patients with hemodynamic
instability due to supraventricular tachyarrhythmia. Large randomized controlled
trials have proven the efficacy of landiolol in the prevention of atrial
fibrillation and atrial tachyarrhythmias in severe acute heart failure or
post-cardiac surgery. Based on lower case-number studies, the administration of
landiolol has been proven to be efficient and safe in rhythm and rate control in
atrial fibrillation complicating acute myocardial infarction, sepsis, and in the
prevention of atrial fibrillation in non-cardiac surgery. Landiolol may be used
in electrical storm, and even during coronary CT-angiography to achieve an
optimal heart rate for imaging. The drug is available in Europe since 2016 and
in Hungary since 2018. Orv Hetil. 2022; 163(2): 53–62.
PENINGKATAN TPACK GURU FISIKA MELALUI MEDIA PEMBELAJARAN BERBASIS GOOGLE APPS
Authors: Amelia Ayu , Nurfalah Erfin , Mulhayatiah Diah 
Published: January 2022

Pada abad-21 seorang guru harus mempunyai keterampilan mengajar khususnya pada teknologi dan informasi. Guru harus mengatur strategi, teknologi, dan media yang akan digunakan untuk menyampaikan informasi dan memandu proses belajar pada peserta didik. Kemampuan TPACK penting dimiliki oleh seorang guru untuk memadukan teknologi dengan pedagogik dan pengetahuannya tentang konten Fisika. Tujuan dari penelitian ini adalah untuk mengetahui peningkatan kemampuan TPACK seorang guru menggunakan media pembelajaran berbasis google apps. Metode yang digunakan adalah kajian pustaka dengan menganalisis enam artikel yang paling relevan. Hasil dari kajian Pustaka tersebut menjelaskan bahwa kemampuan TPACK ini perlu dimiliki oleh seorang guru dalam pembelajaran karena didalamnya sudah terpadu antara pedagogik, pengetahuan, dan teknologinya. Namun pada kenyataannya seorang guru masih belum memiliki kemampuan tersebut. Penggunaan Google Apps dapat digunakan untuk meningkatkan kemampuan TPACK guru karena penggunaan google apps dalam pembelajaran lebih efektif dan hasilnya pun lebih baik daripada pembelajaran yang tidak menggunakan media google apps.
Epilepsy and COVID-19: is infection related to an increased risk of seizure recurrence?
Authors: Odintsova G. V. , Koloteva A. V. , Bannikova V. D. 
Published: January 2022

Background. Over the two last years the novel coronavirus infection, COronaVIrus Disease 2019 (COVID-19), has become one of the urgent health and social problems. Reports on the SARS-CoV-2 neuroinvasiveness raise the question as to whether the infection could be related to an increased risk of seizure recurrence in patients with concomitant epilepsy and COVID-19.Objective: to study the seizure dynamics in patients with epilepsy recovered after COVID-19 by analyzing clinical observations.Material and methods. A single-center retrospective uncontrolled open-label observational study regarding an impact of COVID-19 on the course of epilepsy was performed. Patients with epilepsy recovered after COVID-19 were interviewed between January and February 2021 by using a questionnaire containing three sets of questions. The study included 13 patients suffering from COVID-19 along with epilepsy: 7 cases (54%) of genetic (idiopathic) generalised form, 6 cases (46%) of focal form. The mean age was 34.31±12.68 years.Results. Seizure remission prior to COVID-19 was noted in 10 patients (77%), with no seizure control found in 3 cases (23%) of focal epilepsy at the time of COVID-19. No seizure frequency rise was observed in any case. No recurrent seizures were detected. Electroencephalographic follow-up showed no exacerbated seizures compared to the pre-infection parameters. Monotherapy with anti-epileptic drugs was used in 61% of cases. Levetiracetam monotherapy was administered to 50% of patients, and as a part of a polytherapy regimen – to 100%.Conclusion. The research findings and literature data show that patients with epilepsy are not at greater risk than the general population. Young age, seizure remission, absence of somatic comorbidities, modern drug use with no interaction with antibiotics and antivirals for the coronavirus disease treatment can be considered as positive predictive value of the course of epilepsy with COVID-19. Further studies are required to be performed in a larger patient sample.
Assessing efficacy and tolerability of lamotrigine (Sazar®) in therapy of female idiopathic generalized epilepsy: a multicenter study
Authors: Barkhatov M. V. , Bakhtin I. S. , Belyaev O. V. , Yamin M. A. 
Published: January 2022

Background. Idiopathic generalized epilepsy (IGE) comprises 15–20% among all types of epilepsy. However, specifics of administration for lamotrigine in IGE in the Russian Federation remain poorly investigated, especially in female subjects.Objective: to assess efficacy and potential adverse events (AEs) in girls and females with preserved childbearing potential and verified IGE upon initial treatment with lamotrigine, upon switching to lamotrigine from a first-antiepileptic drug (AED) that provided no full seizure control and/or was coupled to AEs, as well as while introducing lamotrigine as an adjunctive therapy in case a monotherapy achieved no therapeutic efficacy.Material and methods. There were enrolled 54 female patients aged 4 to 40 years (mean age 19.3 years, median 11 years). After verifying IGE, patients received a monotherapy with lamotrigine. In case a patient received a first monotherapy course, but achieved no full seizure control and/or was coupled to AEs due to administered AED, lamotrigine was prescribed as a second AED followed by a potential for further switch to a second monotherapy.Results. It was found that a first monotherapy resulted in the maximum remission rate in patients with isolated generalized tonic-clonic seizures. Lamotrigine efficiently suppressed EEG epiactivity, with observed EEG-remission in 8 out of 16 (50%) patients. While being administered as a second monotherapy, lamotrigine resulted in remission in 87.5% patients. A combination therapy with lamotrigine was required in 22 cases. Most commonly, it was combined with levetiracetam (15 patients). While administering a dual therapy with lamotrigine, remission was observed in 9 patients receiving basal therapy with this drug, as well as 3 and 1 patients receiving valproic acid and topiramate, respectively. Six more patients were observed to demonstrate more than 50% improvement (5 subjects in levetiracetam group and 1 in ethosuximide group).Conclusions. The study demonstrated high efficacy of administered lamotrigine as a first monotherapy as well as a second monotherapy and a combination therapy in girls, adolescent girls and females with IGE. Lamotrigine resulted in no serious AEs that might lead to its cancellation.
The Process of Becoming a Political Personality and the Factors That Determine It (the experience of the German Chancellor Otto von Bismarck)
Authors: Baev Valery G. , Meshcheryakova Svetlana V. 
Published: January 2022

The proposed article attempts to reveal the process of becoming a politician, and not merely an ordinary politician, but one who develops and imposes a large-scale policy that independently determines the options for the development of his country: the creator of the Second Empire in Germany, the great statesman Otto von Bismarck. The goal of the study was to analyze the legal, political, and psychological factors that contributed to the rise of the first civil servant in the empire. The life and fate of each person are in the crosshairs objective and subjective circumstances interact. The role of external, otherworldly forces, colloquially called chance, is also not to be excluded in any such rise. Contrary to popular belief, people are not born clean slates at all. Instead, each bears the stamp of parental education and the personality and health imposed by the genetics of distant ancestors. From the enormous variety of factors, experiences, and relationships within which a personality is formed, the authors of this study chose reference points that, in their opinion, contributed most to forming the contours (or images) of Bismarck as an outstanding politician. These include the aspects of his character that absorbed and reflected the influence of his ancestors and parents (most of all, his mother), as well as the principles that prevailed in the German educational system and the public service of Germany. In this objective review, the subjective (personal) properties of the applicant for the highest administrative position in the state were acutely manifested: a hypermotivation to acquire power and the ability to recognize the importance of representing state interests for themselves.
In their conclusions, the authors relied on collections of Bismarcks letters, on his parliamentary and political speeches, and other documents that accompanied his life. They also relied upon their own interpretation of the distant events of Bismarcks life and times. The study thus acquired an intersectoral character. Although the historical subtext of our research is obvious, the proposed material will also be of interest to modern politicians.
Prevalencia e incidencia de hipertensión arterial en Perú: revisión sistemática y metaanálisis
Authors: Ruiz-Alejos Andrea , Carrillo-Larco Rodrigo M , Bernabé-Ortiz Antonio 
Published: January 2022

Objetivo. Determinar la prevalencia e incidencia de hipertensión arterial, y la prevalencia de diagnóstico previo de hipertensión arterial (autorreportado) en población general adulta del Perú. Materiales y métodos. Revisión sistemática y metaanálisis de estudios epidemiológicos disponibles en LILACS, EMBASE, MEDLINE y Global Health. Se incluyeron estudios que siguieron un muestreo aleatorio de la población general adulta. El tamizaje y estudio de los manuscritos fue realizado por dos investigadores de forma independientemente. Se hizo metaanálisis de efectos aleatorios para cuantificar la prevalencia e incidencia global. Los manuscritos fueron evaluados con la escala Newcastle-Ottawa para evaluar el riesgo de sesgo. Resultados. Se tamizaron 903 artículos, y se incluyeron 15 manuscritos para prevalencia, 8 para prevalencia de diagnóstico previo, y 4 para incidencia de hipertensión. El metaanálisis mostró una prevalencia agregada de hipertensión de 22,0% (IC 95%: 20,0% - 25,0%; I2=99,2%). Esta prevalencia fue menor en estudios nacionales [20,0% (IC 95%: 17,0% - 22,0%; I2=99,4%] que en subnacionales [24,0% (IC 95%: 17,0% - 30,0%; I2=99,2%]. La prevalencia global de diagnóstico previo de hipertensión fue 51,0% (IC 95%: 43,0% - 59,0%; I2=99,9%). La incidencia global fue de 4,2 (IC 95%: 2,0 – 6,4; I2=98,6%) por cada 100 personas-año. Los manuscritos estudiados no presentaron alto riesgo de sesgo. Conclusiones. Nuestros hallazgos muestran que uno de cada cinco peruanos tiene hipertensión, y que aparecen cuatro nuevos casos por 100 personas en un año, además solo la mitad de los pacientes hipertensos tienen el diagnóstico previo de su condición.
Factores asociados a letalidad por COVID-19 en un hospital de la región Cajamarca en Perú
Authors: Anyaypoma-Ocón Walter , Ñuflo Vásquez Sandra , Bustamante-Chávez Hugo Cesar , Sedano-De la Cruz Edyson , Zavaleta-Gavidia Víctor , Angulo-Bazán Yolanda 
Published: January 2022

Objetivo. Identificar las características clínicas y epidemiológicas relacionadas a la letalidad en pacientes hospitalizados por COVID-19 en el Hospital Simón Bolívar de Cajamarca, durante junio-agosto de 2020. Materiales y métodos. Cohorte retrospectiva, con información recolectada de historias clínicas y sistemas oficiales de vigilancia epidemiológica (NOTIWEB, SISCOVID y SINADEF), sobre pacientes hospitalizados con diagnóstico confirmado de COVID-19. Se recolectó información sobre factores sociodemográficos y clínicos, considerando como desenlace el egreso (fallece/sobrevive) y los días de hospitalización. Resultados. La tasa de letalidad intrahospitalaria fue 39,6%, encontrándose diferencias significativas entre el tiempo de hospitalización y la condición de egreso en las personas mayores de 60 años (p0,001). La edad mayor de 60 años (HR: 2,87; IC95%: 1,76-4,68),) solicitud de cama UCI no atendida (HR: 3,49; IC95%: 2,02-6,05), saturación de oxígeno menor a 80% al ingreso (HR: 2,73; IC95%: 1,35-5,53) y el uso de ivermectina (HR: 1,68; IC95% 1,06-2,68) fueron factores asociados a letalidad. El modelo de Machine Learning (ML) elegido consideró que las variables con mayor importancia fueron la saturación de oxígeno, la edad mayor de 60 años, tiempo de hospitalización y tiempo de síntomas. Conclusión. Los factores que podrían incrementar la letalidad en pacientes hospitalizados por COVID-19 fueron la edad, saturación de oxígeno menor a 80%, uso de ivermectina en la terapéutica hospitalaria y la solicitud no atendida de camas UCI. Futuros estudios con una mejor representatividad podrían confirmar estas posibles relaciones a nivel regional o nacional.
Evaluación de la respuesta humoral inducida por la vacuna BBIBP-CorV mediante la determinación de anticuerpos neutralizantes en personal sanitario peruano
Authors: Soto Alonso , Charca-Rodríguez Flor De María , Pareja-Medina Mario , Fernandez-Navarro Manuel , Altamirano-Cáceres Karina , Sierra Chávez Elizett , Raraz-Vidal Jarvis , Cabezudo-Pillpe Nestor , Velarde-Rodríguez Melissa , Alcántara-Díaz Andrés 
Published: January 2022

Objetivo. Determinar el título de anticuerpos frente al dominio de unión al receptor (RBD) de la proteína espiga (S) en personal de salud entre la 4.ª y 12.ª semana luego de haber recibido la vacuna BBIBP-CorV (Sinopharm). Materiales y métodos. Se incluyeron 168 trabajadores de salud de dos hospitales de la región, quienes cumplían el esquema completo con vacuna de Sinopharm, y se realizó la medición de anticuerpos en suero mediante la prueba Elecsys® Anti-SARS-CoV-2. Resultados. Todos los participantes desarrollaron anticuerpos frente al dominio RBD. El valor mínimo fue de 1,78 U/mL. En 70 (41,7%) participantes se encontraron niveles iguales o por encima de 250. La media geométrica fue de 82,6 (IC 95% 67,8-100,6). Las mujeres presentaron un mayor nivel de anticuerpos. El grupo de participantes en los que se midieron anticuerpos entre las semanas 4 y 7 posvacunación mostró niveles de anticuerpos significativamente mayores que los pacientes cuyas determinaciones fueron realizadas entre las 10 y 12 semanas posvacunación. Entre los pacientes con antecedente de COVID-19, los niveles de anticuerpos se encontraron en cifras iguales o por encima de 250 U/mL en el 88% de casos, en comparación con 6% entre aquellos sin antecedente de COVID-19, (p0,001). Conclusión. Todos los participantes inmunizados con la vacuna BBIBPCorV presentaron positividad a anticuerpos frente al RBD de la proteína S del SARS-CoV-2. Es necesario evaluar la correlación entre la magnitud de los títulos y la protección frente a COVID-19 y el tiempo de protección conferido por la vacuna.
Asociación entre la necesidad de cuidados paliativos y enfermedades crónicas en pacientes atendidos en un hospital peruano
Authors: Pinedo-Torres Isabel , Intimayta-Escalante Claudio , Jara-Cuadros Diego , Yañez-Camacho Walter , Zegarra-Lizana Paolo , Saire-Huamán Reynaldo 
Published: January 2022

Objetivos. Evaluar la asociación entre las enfermedades crónicas (EC) y la necesidad de cuidados paliativos (NCP). Materiales y métodos. Se realizó un estudio transversal analítico en un hospital peruano durante el 2019. Se incluyó a pacientes hospitalizados con EC y se excluyó gestantes y a los hospitalizadosen unidades críticas. En la evaluación de la NCP se aplicó el instrumento SPICT-ESTM, adicionalmente se evaluaron características sociodemográficas y clínicas. La fuerza de asociación se calculó con regresiones de Poisson con varianza robusta para estimar razones de prevalencia crudas (RP) y ajustadas (RPa) porconfusores. Resultados. Se evaluó 172 pacientes, la media de edad fue 61 años, donde el 54,7% eran varones y 123 pacientes tenían NCP. En el modelo crudo se encontró asociación con tener enfermedad cerebrovascular (RP: 1,23; p=0,028), cualquier tipo de cáncer (RP: 1,38; p0,001), cardiopatías (RP: 1,29; p=0,007), nefropatía (RP: 1,42, p0,001) y enfermedad de Alzheimer (RP: 1,42; p0,001). La asociación se mantuvo en la mayoría de EC evaluadas en el modelo ajustado, excepto para cardiopatía (RPa: 1,11; p=0,320). La fuerza de asociación fue menor en el caso de diabetes mellitus (RP: 0,78; p=0,044). Conclusión. La NCP en pacientes con enfermedades crónicas hospitalizados es alta y más frecuente en pacientes con cáncer, enfermedad cerebrovascular, problemas renales y enfermedad de Alzheimer. Los programas de cuidado de pacientes con diabetes mellitus pueden disminuir la NCP.
In Defense of Knowing, In Defense of Doubting: Cicero Engages Totalizing Skepticism, Sensate Materialism, and Pragmatist Realism in "Academica"
Authors: Prus Robert 
Published: January 2022

Whereas contemporary scholars in the social sciences and humanities often envision themselves as exceptionally, if not uniquely, attentive to the problematics of human knowing and acting, the competing philosophies of totalizing skepticism, sensate materialism, divine worldviews, and pragmatist realism have a much more enduring presence in Western social thought.
Plato (c420-348BCE) introduces a broad array of philosophic standpoints (theological, idealist, skepticist, materialist, and pragmatist) in his texts and Aristotle (c384-322BCE) addresses human knowing and acting in more distinctively secular, pluralist terms. Still, more scholarly considerations of human knowing and acting would be comparatively neglected by Cicero’s time and even more so after his era.
Although much overlooked by those in the human sciences, Cicero’s Academica re-engages a number of highly consequential issues pertaining to the matter of human knowing and acting. Likewise, whereas Christian theologians often were hostile to heathen (relativist, materialist, pragmatist) philosophic viewpoints, important residues of these approaches would remain part of the Western intellectual tradition though Augustine’s (c354- 430 BCE) works.
Academica is centered on the historically sustained skepticist emphases of Plato’s Academy (c350-50CE) but Cicero’s text also attends to some competing viewpoints that developed along the way. In addition to (1) acknowledging some of the intellectual shifts in Plato’s Academy over three centuries, this statement also (2) provides a pragmatist critique of the totalizing skepticism of the Academicians, and (3) illustrates the ways in which Cicero, as a representative and defender of Academician skepticism, deals with critiques pertaining to the problem of human knowing and acting.
Thus, whereas Cicero is best known as a rhetorician and his text is presented as an instance of rhetorical interchange, Cicero’s Academica also may be seen as “a defense of knowing” and “a defense of doubting,” two of the most central features of scholarship.