bluuebunny/crossref_metadata_2025_split huggingface dataset:
“No soy vendedora de medicamentos, soy médico”. La prescripción médica en los consultorios adyacentes a farmacias, juego de tensiones y negociaciones
Authors: Morán Pérez Ana Victoria 
Published: July 2022

Con la expansión de los consultorios adyacentes a farmacias (CAF) en México, surge la necesidad de indagar cómo ocurre la prescripción de medicamentos en estos establecimientos, ello a causa de la consustancial vinculación entre consultorio y farmacia, característica central de los CAF. Este artículo tiene el objetivo de describir las prácticas de prescripción en consultorios adyacentes a farmacias ubicados al sur de la Ciudad de México, y analizar las determinantes que influyen en éstas, así como los significados que el personal médico atribuye a esta actividad. Se utilizó una metodología cualitativa bajo la cual se realizaron entrevistas a profundidad y conversaciones informales que recuperan las perspectivas de 22 médicos sobre el acto prescriptivo. Se muestran los factores que determinan los criterios para prescribir, la existencia de posibles conflictos de interés y las tensiones- negociaciones —entre médicos, pacientes, dispensadores y propietarios de la farmacia— que están articuladas en torno a los medicamentos. Las conclusiones apuntan a que los CAF son un espacio donde convergen actores con intereses y expectativas diferenciales pero que comparten un referente en el medicamento, en tanto objeto-proceso polisémico y multidimensional. Asimismo, se concluye que estos consultorios cumplen una función doble: brindar atención a la salud, a la vez que constituirse como nuevos mercados de consumo farmacéutico.
Assessing the impact of COVID-19 on the Indonesian tourism industry
Authors: Anele Kalu Kingsley 
Published: July 2022

Tourism plays a significant role in the economic development of Indonesia. Aside from being a source of revenue, tourism creates employment opportunities and promotes the hospitality industry. However, the emergence of COVID-19 has adversely implicated on tourism in Indonesia, as international travel restrictions have been imposed by many countries. This paper dialectically analysed the impact of COVID-19 on the Indonesian tourism industry. It was observed that labour and the earnings in the tourism were severely affected by COVID-19. This was because the number of foreign tourists that visited Indonesia declined significantly as countries partially shut down their economy and imposed travel restrictions. The paper reviewed the government of Indonesia’s regulations and programmes and the tourism sector’s actions to mitigate the impact of COVID-19 on the country’s economy. It argued that government should introduce structures and guidelines for the introduction of smart tourism through non-contact, smart and personalised travel in Indonesia. Keywords [COVID-19, Indonesia, Tourism, Presidential Regulations, Travel restriction, Economic shutdown]
Dinamika Partisipasi Masyarakat Dalam Tata Kelola Ekowisata Hutan Mangrove Wana Tirta di Kabupaten Kulon Progo
Authors: Arrahmah Novriza , Wicaksono Ferri 
Published: July 2022

ABSTRACTEcotourism is part of the development of tourism in Indonesia, where it concerns on optimizing natural tourism travel including knowledge, in the form of preserving the environment, which encourages to carry out conservation activities for the environment and natural resources, in accordance with the characteristics of Indonesia's regional conditions. Wana Tirta Mangrove Forest (WTMF) is known as one of the ecotourism attractions which is developed in Kulon Progo Regency. This research specifically discusses the dynamic of Community Participation in the management. The purpose of this study is to identify and analyze using three-phases methods developed by Noronha, namely, Discovery, Local Response and Initiative, and Institutionalization. This research focuses on seeing the realization of a community participation initiative activity as well as the role of the community in the Local Response and Initiative phase of greenwood theory, where the role of the community itself is related to the involvement directly and most instrumentally in the management of ecotourism in the WTMF area. At the end of this study, researchers wanted to provide an overview of driving factors, supporting factors, and inhibitory factors. ABSTRAKEkowisata menjadi bagian dari pengembangan pariwisata di Indonesia, yang mana ekowisata berkonsentrasi dalam melakukan optimalisasi perjalanan wisata alam meliputi pengetahuan, dalam bentuk melestarikan lingkungan, yang mendorong untuk melakukan kegiatan konservasi terhadap lingkungan dan sumber daya alam, sesuai dengan dengan karakteristik kondisi wilayah Indonesia. Hutan Mangrove Wana Tirta (HMWT)diketahui sebagai salah satu potensi ekowisata yang sedang di kembangkan di Kabupaten Kulon Progo. Penelitian ini secara spesifik membahas tentang Dinamika Partisipasi Masyarakat Dalam Tata Kelola Ekowisata. Tujuan penelitian ini ingin mengidentifikasi dan menganalisis menggunakan tiga metode tahapan yang dikembangkan oleh Noronha yaitu, fase Discovery, ,fase Local Response and Initiative, dan fase Institutionalization. Penelitian ini berfokus ingin melihat perwujudan dari suatu aktivitas inisiatif partisipasi masyarakat maupun peran masyarakat dalam fase Local Response and Initiative pada teori Greenwood, dimana peran masyarakat itu sendiri berkaitan dengan adanya keterlibatan secara langsung maupun yang paling berperan dalam pengelolaan ekowisata. Di akhir penelitian ini, peneliti ingin memberikan beberapa gambaran faktor pendorong, faktor pendukung, dan faktor penghambat.
Comparative clinical and economic assessment of polatuzumab vedotin therapy in combination with bendamustine and rituximab for adult transplantation-ineligible patients with relapsed/refractory diffuse large B-cell lymphoma
Authors: Dyakov I. N. , Bushkova K. K. 
Published: July 2022

Aim. To evaluate the pharmacoeconomic feasibility of using polatuzumab vedotin in combination with bendamustine and rituximab for the treatment of adult transplantation-ineligible patients with relapsed/refractory diffuse large B-cell lymphoma.Materials and methods. Study design - retrospective analysis of literature data. Pharmacoeconomic research methods - clinical and economic analysis (incremental cost-effectiveness analysis, case-based approach) using sensitivity assessment. The sources of the drug efficacy data were publications on conducted clinical trials; on the drugs cost -the State register of maximum selling prices, data from the manufacturer's company.Results. Polatuzumab vedotin is the unique drug from the class of monoclonal antibody-antimitotic agent conjugates registered in Russia for the treatment of adult transplantation-ineligible patients with relapsed/refractory diffuse large B-cell lymphoma. for this reason a case-based approach was applied as part of the cost-effectiveness analysis. As a result of clinical and economic analysis, it was found that the cost of progression free life-year added when using polatuzumab vedotin in combination with bendamustine and rituximab in patients with relapsed/refractory diffuse large b-cell lymphoma by 50.7 %, or by 11.4 million rubles, lower than the cost of progression free life-year added when using brentuximab vedotin in patients with relapsed/refractory Hodgkin's lymphoma. The sensitivity assessment showed the stability of the obtained results to changes in the input parameters of treatment cost and efficacy in a wide range of values.Conclusion. Use of polatuzumab vedotin in combination with bendamustine and rituximab for the treatment of adult transplantation-ineligible patients with diffuse large B-cell non-Hodgkin's lymphoma is pharmacoeconomically justified and appropriate.
Polymorphisms of the <i>TPMT</i>, <i>NUDT15</i> genes and 6-mercaptopurine toxicity profile in adult patients with Ph-negative acute lymphoblastic leukemia/lymphomas on the ALL-2016 protocol
Authors: Kotova E. S. , Gavrilina O. A. , Yakutik I. A. , Sudarikov A. B. , Chabaeva Yu. A. , Kulikov S. M. , Beksaev S. G. , Troitskaya V. V. , Isinova G. A. , Sokolov A. N. , Fidarova Z. T. , Lukyanova I. A. , Abramova A. V. , Dvirnyk V. N. , Galtseva I. V. , Obukhova T. N. , Parovichnikova E. N. 
Published: July 2022

Background. 6-mercaptopurine (6-MP) is a drug that is included in the treatment protocols for children and adults with acute lymphoblastic leukemias/lymphomas (ALL/LBL). It is known that individual differences in 6-MP tolerance can be explained by the TPMT and NUDT15 polymorphisms.Aim. To determine 6-MP toxicity profile in adult patients with Ph-negative ALL/LBL treated by ALL-2016 protocol, depending on the TPMT and NUDT15 polymorphisms.Materials and methods. The study included 54 adult patients with Ph-negative ALL/LBL (40 male and 14 female). The median age was 31 (18-51) years. T-ALL/LBL was diagnosed in 29 patients, B-ALL/LBL - in 22, acute leukemia with a mixed immunophenotype - in 3. All patients received treatment according to the multicenter study ALL-2016 (ClinicalTrials.gov, NCT03462095). polymorphisms in NUDT15 (*2, *3) and TPMT (*2, *3A, *3B, *3C) genes were detected using the allele-specific real-time polymerase chain reaction. Genomic DNA was extracted from patients peripheral blood samples. On the induction and consolidation therapy by the protocol, the received and proper 6-MP doses were calculated for all the patients. Drug toxicity was evaluated based on clinical and laboratory data.Results. TPMT and NUDT15 polymorphisms were detected in 11 (20 %) patients, more often in B-ALL - 7 (32 %) of 22 (p <0.05). A lower dose of 6-MP was received by patients with TPMT, NUDT15 polymorphisms only at consolidation IV (p = 0.01). we didn't find a correlation between the 6-MP toxicity and the polymorphisms in our patients (p >0.05).Conclusion. There were no differences in the received dose of 6-MP and the incidence of toxicity in adult patients between Ph-negative ALL/LBL with or without TPMT and NUDT15 polymorphisms treated according to ALL-2016 protocol (p >0.05). further studies including evaluation of 6-MP metabolites concentrations are required for a more complete understanding of the metabolism of this drug.
Translation and creation in Zheng Zhenduo’s translation of “Apollo and Daphne”
Authors: Nico Silvia 
Published: July 2022

Zheng Zhenduo, the Chinese translator, has made great contributions to the translation and introduction of Greek literature, and also put forward unique insights for the construction of Chinese translation theory. Based on Zheng Zhenduo 's translation theory, this article takes Zheng Zhenduo’s translation of Apollo and Daphne (Aipoluo yu Dafen), contained in Lian’ai de gushi (1929), a collection of Greek mythological stories that he selected and translated from English into Chinese as an example, it compares Zheng’s version and English version to analyze whether or not he remained consistent to his own translation theory when translating Greek mythological stories.
Percepção dos alunos do Ensino Médio quanto aos Conteúdos Básicos de Mecânica, pré- e pós-construção e experimentações das “Bazucas de Batata”
Authors: Silva Simone Rodrigues , Santana Arouche Wennerson Afonso , De Araújo Roberto Camara 
Published: July 2022

Neste trabalho busca-se oferecer a partir das bazucas de batatas oportunidade para um ensino contextualizado de física, em especial aos conteúdos de cinemática e dinâmica tornando-o mais dinâmico e prazeroso ao invés de tão somente inúmeros cálculos matemáticos. Este artigo apresenta como proposta um estudo teórico com abordagem no dia a dia do aluno, além de propor a utilização de um produto educacional que possibilita um estudo interdisciplinar e contextualizado. Neste trabalho são encontrados referenciais teóricos que foram utilizados como guia para a abordagem teórica e prática adotada junto aos alunos da 1ª. Série do Ensino médio do Colégio de aplicação da Universidade Federal de Roraima durante a elaboração e aplicação do produto educacional. Salienta-se que a pesquisa realizada ocorreu no período de pandemia do COVID-19, logo, a sua elaboração e aplicação do produto ocorreu à distância por meio das mídias digitais google meet e youtube. Apesar das perdas didáticas relativas ao fato dos alunos não terem participado presencialmente da aplicação do produto, avalia-se que o mesmo apresenta um elevado potencial para o ensino de física podendo ser explorado visando uma aprendizagem significativa e satisfatória.
A prospective randomised low dose finding study of preservative free 1% cloroprocaine in spinal anesthesia for perineal surgeries
Authors: Kanchanamala B , Karthik VJ , Kesavalakshmi S , Narasimman  
Published: July 2022

Ambulatory surgery has become popular in this era which has resulted in the advent of newer short acting anaesthetic drugs to suit early ambulation of post operative patients and discharge and early resumption of daily activities. This in turn reduces cost of care, increased availability of beds for sick patients, lower risk of resistant bacterial strain transmission and faster return to work and social activities., This study was aimed to find out the effective low dose of 1% chloroprocaine for lower limb ambulatory surgeries performed as day care procedures. 93 consented patients were randomized to three groups of 31 each to receive 20 mg, 25 mg and 30mg of 1%chloroprocineintrathecally. Sensory and motor block was assessed.: The collected data was analysed using IBM.SPSS statistics23.0 Version.The demographic data in all three groups were comparable. The onset of motor blockade was profound in patients receiving 30 mg of chloroprocaine compared to 20 or 25 mg. The blook persisted for longer duration with delayed voiding of urine, delay in unassisted ambulation inpatients receiving 30 mg of 1% chloroprocaine.
Design A Mini Power Bank As A Storage Electrical Energy of Dragon Fruit Stems
Authors: Rahmadani Eza Rahmadani , Helendra Helendra , Husna Husna 
Published: July 2022

Research has been done on designing a mini power bank using dragon paste as a source of electrical energy. The voltage and current generated by this dragon paste and power bank are measured using a digital multimeter. Dragon paste is used in series and parallel. The voltage generated by the dragon paste is connected to a DC step up. The use of step-up dc aims to increase the dragon paste voltage so that it can or can charge lithium-ion batteries that have been arranged in parallel using the power bank kit module.

Keywords: Dragon Paste, Module Kit, Powerbank
Survey of the Relationship Between Student Learning Independence and Scientific Learning Outcomes Islamic Junior High School (Madrasah Tsanawiyah) in South Jakarta
Authors: Awaliyah Fitri 
Published: July 2022

The purpose of this study was to clarify the relationship between student learning independence and scientific learning outcomes. The method used in this survey is a survey. The population of this survey was class VIII Madrasah Tsanawiyah Negeri in South Jakarta, for a total of 720 students, and the sample size of this survey was 88 students. Sampling was performed using a combination of clustering, proportional, and random techniques. This survey data collection is in the form of a survey using the Likert scale model that respondents need to fill out and a data analysis using the SPSS 20 program. The result is a value of Sig = 0.000 < 0.05 and tcount = 3.727, H0 is discarded. This means that student learning independence is actively associated with scientific learning outcomes.
On the Variability of Benthic Foraminiferal Species of the Genus Ramulina in the Tethys
Authors: Anan Haidar Salim 
Published: July 2022

ABSTRACT
Eight small benthic foraminiferal species of the Lagenid genus Ramulina are common in the Late Cretaceous and Paleogene from some Tethyan localities: North Atlantic (USA, Mexico, Caribbean); Europe (France, Germany, Czech Republic, Bulgaria, Ukraine); Northeast Africa (Egypt); Southwest Asia (Jordan, UAE, Iran, Turkmenia); and South Asia (Pakistan). These species are: Ramulina arkadelphiana, R. elkhoudaryi, R. elongata, R. futyani, R. globulifera, R. navarroana, R. ornata, and R. pseudoaculeata. Another four identified species are believed here to be new: Ramulina ismaili, R. orabii, R. plummerae, and R. salahii.
Western to Central Equatorial Pacific Planktic Foraminiferal Fluxes: Implication for the Relationship Between Their Assemblage and Warm Pool Migration from 1999 to 2002
Authors: Yamasaki Makoto , Tokumoto Ryo , Sasaki Akira , Shimada Chieko , Schiebel Ralf 
Published: July 2022

ABSTRACT
Time-series sediment trap experiments were carried out in the western to central equatorial Pacific (Sites MT3, MT4, MT5, and MT7) from 1999 to 2002, over the transitional time period from La Niña to El Niño conditions, in order to evaluate temporal variability in planktic foraminiferal fluxes and their assemblages. The foraminiferal test flux follows a trophic gradient from higher fluxes in the Equatorial Upwelling Region (EUR) and lower fluxes in the Western Pacific Warm Pool (WPWP) region. Globigerinoides ruber commonly dominates in all sites through the experimental period. Trilobatus sacculifer, Globigerinita glutinata, and Neogloboquadrina dutertrei occurred especially in the WPWP. In contrast, Globigerina bulloides and Pulleniatina obliquiloculata characterized the fauna in the EUR.
A change in hydrologic conditions from La Niña to El Niño was documented along the sites during the sampled time interval. Simultaneous with an eastward advancement of the WPWP, the EUR retreated to the east. Rapid decreases in the fluxes of G. ruber, G. bulloides, and P. obliquiloculata were recognized immediately after the more oligotrophic WPWP conditions prevailed at Sites MT4, MT5, and MT7. Fluxes of the total planktic foraminifer assemblage increased both in the EUR and in the western side of the WPWP under full El Niño conditions during the second half of 2002. Such increases in test fluxes in the western side of the WPWP were mainly attributed to G. ruber and N. dutertrei, suggesting inputs of eutrophic waters from the northern coastal area of Papua New Guinea. Test fluxes under El Niño conditions in the WPWP were at the same level as those in the EUR, giving rise to strongly increased carbonate fluxes in the western equatorial Pacific.
Association of PRLR, IGF1, and LEP genes polymorphism with milk production and litter size in Egyptian Zaraibi goat
Authors: El-Shorbagy Haidan M. , Abdel-Aal Ehab S. , Mohamed Shaimaa A. , El-Ghor Akmal A. 
Published: July 2022

Abstract
Studying variation in genes responsible for physiological characters is important to enhance goat productive and reproductive efficiency. This study aimed to detect specific nucleotide polymorphisms in Prolactin receptor (PRLR), Insulin like growth factor (IGF1) and Leptin (LEP) genes and their correlation with milk production (MP) and litter size (LS) traits in Zaraibi goat. PCR-SSCP products of different patterns of each gene were sequenced and aligned to reveal two single nucleotide polymorphisms (SNPs) (T > C) and (G > A) in 3’UTR of PRLR gene and registered on NCBI with accession numbers OM418863 for TT and OM418864 for CT, while (G > A) SNP was registered as OM418861 for GG and OM418862 for AG in exon 10. TT, CT, AG and GG genotypes were distributed in the studied animals with frequencies 0.43, 0.57, 0.65 and 0.35, respectively. While alleles C, T, A and G frequencies were 0.28, 0.72, 0.32 and 0.68, respectively. CT and AG genotypes associated significantly (P < 0.05) with higher MP and LS respectively. By studying the haplotypes of PRLR, C-A and T-A were associated with the highest and the lowest level of MP respectively. For LS, T-A and C-G showed significant correlation with the highest and the lowest rate respectively. Regarding IGF1 gene, two SNPs were detected; T74C at exon 4 which registered on NCBI as (OM418860), and combined SNPs as ins. G470, A531G and T534C (PP genotype) at 5’ flanking region that registered as (OM418859). For LEP, only one SNP was found in intron 2 (G281A) which submitted to NCBI as (OM418855). All detected SNPs have shown to be involved in regulating the MP or LS as reproductive traits in goat.
A Blended-Learning Course for a Global Health Workforce: Evaluation of Quality Indicators and a Peer-Review Process for Online Learning
Authors: Crawford Ana Maria , Changoor Alana T. , Rubio-Martinez Rodrigo , Mohammed Alhassan Datti , Ntambwe Papytcho T. 
Published: July 2022

Abstract
Background: Inequities in health outcomes across contexts are in part attributable to gaps in available medical training programs particularly impacting low- and middle-income countries. Shifting education resources online presents an opportunity to democratize access but presents challenges. Quality in digital scholarship is crucial to prevent learners’ consumption of misinformation, while ensuring continued scholarly contribution from medical educators. Quality indicators typical for journals do not neatly apply to online resources and remain biased against those facing resource constraints. Similarly, widely applied peer-review processes for online learning content are lacking or inconsistent. Methods: Partners developed and implemented a 12-month, case-based discussion webinar series addressing Oxygen Therapy and Critical Care for healthcare workers facing the COVID-19 pandemic. Using the survey responses from webinar panelists across the globe, this project evaluated whether 3 criteria were met by panelists to serve as peer-reviewers and evaluated the quality of the blended-learning program by applying Glassick’s standards of scholarship and the 13 quality indicators for online content developed by Lin et.al.Results: There was a response rate of 72%. Fifty-six percent of respondents were from high-income countries and 44% were from low- and middle-income countries. Most panelists met criteria set for peer-reviewers, although criteria were met more often by those from high-income countries. Most respondents perceived preparation of materials for the blended -learning sessions as extremely adequate, appropriate, and effective. The online content was evaluated highly across the three domains of content, credibility, and design.Conclusions: The Oxygen Therapy and Critical Care series was well-received by learners and panelists alike. Quality across all indicators was deemed high for both the blended-learning and the online learning components. Defining quality indicators assists in both prospective design of online learning and during peer-review processes. The process of using webinar panelists as peer-reviewers is feasible, appropriate and presents opportunities for experts from low- and middle-income countries.