bluuebunny/crossref_metadata_2025_split huggingface dataset:
Interleukin 8 and bronchial eosinophils in patients with asthma and cold airway hyperresponsiveness
Authors: Pirogov A. B. , Prikhodko A. G. , Perelman J. M. 
Published: April 2022

Introduction. Cold airway hyperresponsiveness (CAHR) is common in patients with asthma. The effect of inhaled corticosteroid/long-acting β2-agonist therapy (ICS / LABA) on its severity, and the role of IL-8, and the eosino-philic profile of bronchial inflammation have not been studied. Aim. To study the dynamic relationship between the level of IL-8 and eosinophilic inflammation in the bronchi of asthma patients with CAHR using anti-inflammatory combined therapy with ICS / LABA. Materials and methods. Patients with asthma (n=59) received ICS / LABA for 24 weeks. The level of disease control (ACT, points), cellular composition of induced sputum (IS), bronchial response (ΔFEV1IHCA, %) to 3-minute isocapnic hyperventilation with cold (-20ºС) air (IHCA) was assessed. Exhaled breath condensate (EBC) was collected before and after the IHCA, in which the concentration of IL-8 (pg/mL) was determined. Results. Group 1 included 28 patients with CAHR (ΔFEV1IHCA = -14.1 ± 1.7%), group 2 included 31 patients with no response to cold bronchoprovocation (ΔFEV1IHCA = - 3.0 ± 2.4 %, p < 0.0001). Initially, patients of groups 1 and 2 had no differences in ACT (16.8±0.6 and 15.7 ± 0.8 points), FEV1 (92.5 ± 3.6 and 87.8 ± 2.2%), the number of eosinophils in sputum (8.0 ± 2.4 and 4.7 ± 1.3%, respectively, p > 0.05). The concentration of IL-8 before and after the IHCA test in group 1 was 131.2 ± 18.0 and 146.3 ± 23.5 pg/mL, respectively (p > 0.05), in group 2 it was 130.5 ± 8.8 and 149.9 ± 18.4 pg/mL, respectively (p>0.05). After treatment, the airway response to the IHCA significantly decreased in group 1 (ΔFEV1IHCA = - 8.8 ± 1.5 %, p < 0.01), in group 2 it remained unchanged (- 3.6 ± 1.3 %, p > 0.05). The level of asthma control in group 1 increased to 20.7 ± 1.6 ACT points (p < 0.01), in group 2 – up to 19.7 ± 1.7 (p < 0.05). The lung function did not change. After treatment, the level of IL-8 before and after the IHCA in group 1 did not change (89.8 ± 11.7 and 85.5 ± 7.8 pg/mL, p > 0.05), as did the number of eosinophils (8.0 ± 2.4 and 6.2 ± 3.1 %, p > 0.05). In group 2, the level of IL-8 before and after IHCA decreased from 89.2 ± 7.7 to 73.9 ± 10.3 pg/mL (p < 0.01), the concentration of eosinophils decreased from 4.7 ± 1.3 up to 1.5 ± 0.57 % (p < 0.05). Conclusion. 24-week therapy with ICS/LABA in patients with CAHR leads to improved asthma control, a decrease in the severity of cold bronchospasm, without being accompanied by changes in the level of IL-8, which affects the dynamics of the concentration of eosinophils in the bronchi.
Melanoma with respiratory damage
Authors: Grigorenko A. A. , Voytsekhovskiy V. V. , Roshchin S. N. , Filatova E. A. 
Published: April 2022

Aim. Demonstration of cases of melanoma of rare localization – with damage to the respiratory system. Materials and methods. A brief review of the literature on non-skin melanomas is presented; special attention is paid to melanomas of airways and lungs, primary localization and metastatic lesions. Clinical observations of this pathology are given. Results. The paper presents two rare cases from the personal practice of the authors: the diagnosis of primary melanoma of the paranasal sinuses with germination of the base of the skull and metastatic lung damage, in which it was difficult to determine the primary localization of the tumor. In both cases, differential diagnosis was carried out with other formations in the respective areas. The final diagnosis was made by histological and immunohistochemical studies. Conclusion. The diagnosis of melanoma with damage to the respiratory organs requires differential diagnosis with other formations of this localization. A histological and immunohistochemical study helps to establish the final diagnosis.
"SLAMETHAN ASSÎR" as A Media of Harmonization between Individual Happiness and Social Peace
Authors: Arifin Samsul 
Published: April 2022

The kiai of the Besuki Residency in the past, had local wisdom in carrying out social harmonization to achieve mutual happiness. One of them is through "Slamethan Assîr" which is carried out by the community so that they can grow and develop in their careers. This study aims to understand the meaning of achieving happiness and prosperity in life through "Slamethan Assîr" and its implementation in career development, from the perspective of self-concept theory of career development. This research uses the ethnographic method. The results of this study indicate that "Slamethan Assîr" means as a guide that a career must contain the value of worship, hoping for blessings for the family, and giving charity to maintain harmony with neighbors. Career development is a process of developing self-concept; self-quality and competence and paying attention to the environmental context. The standard of career success is to feel prosperous and happy with family, friends, or neighbors and must be in line with the pleasure of Allah. So they will avoid corrupt, fraudulent, and other heinous acts. This research is useful for the development of the psychology of entrepreneurship and career
Enriched Pro-Categories and Shapes
Authors: Uglešić Nikica 
Published: April 2022

Given a category C and a directed partially ordered set J, a certain category proJ-C on inverse systems in C is constructed such that the ordinary pro-category pro-C is the most special case of a singleton J ≡ {1}. Further, the known pro*-category pro*-C becomes proN-C. Moreover, given a pro-reflective category pair (C, D), the J-shape category ShJ(C, D) and the corresponding J-shape functor SJ are constructed which, in mentioned special cases, become the well known ones. Among several important properties, the continuity theorem for a J-shape category is established. It implies the “J-shape theory” is a genuine one such that the shape and the coarse shape theory are its very special instances.
Hacia la Construcción de un Código Interpretativo por la Corte de Constitucionalidad de Guatemala respecto al Derecho Humano a un Ambiente Sano
Authors: López Yuman Rosa María 
Published: April 2022

La interpretación de los preceptos constitucionales que se caracterizan por su generalidad y ambigüedad, constituyen un reto permanente para las juezas y jueces constitucionales, puesto que es a ellos a quien les corresponde atribuirles sentido, labor que implica la búsqueda de un código interpretativo que se ajuste a los principios y métodos que informan la interpretación de los derechos humanos en general y en particular del derecho humano a un ambiente sano, a fin de ajustarlos a la realidad y necesidad social; sin que sea necesaria una reforma a la Ley Fundamental.

Abstract
The interpretation of Constitutional Precepts characterized by their generality and ambiguity, constitute a permanent challenge for Constitutional Judges, since it is up to them to give them meaning, a task that implies the search for an interpretive code that fits to the principles and methods that inform the interpretation of Human Rights in a general concept, and in particular the human right to a healthy environment, in order to adjust them to the reality and social needs; without requiring a reform of the Fundamental Law.
La tutela constitucional de la memoria histórica: análisis del caso del Archivo Histórico de la Policía Nacional y la figura de la “actuación inmediata de la sentencia impugnada”
Authors: Aldana Moscoso Miguel Angel 
Published: April 2022

Este texto examina la situación del Archivo Histórico de la Policía Nacional -AHPN- desde la óptica jurídica, en referencia a la acción constitucional de amparo promovida por el Procurador de los Derechos Humanos, en el año 2019, contra el Ministerio de Cultura y Deportes y el Ministerio de Gobernación. En particular, se estudia el problema relativo al peligro que supone la demora de los tribunales constitucionales y las autoridades gubernamentales competentes en librar las órdenes y emprender las medidas requeridas para prevenir una situación irreparable que haga imposible restituir las cosas a su estado anterior. Para tal fin, se repasan los aspectos más relevantes de la sentencia de amparo recaída en el expediente 1281-2019 de la Corte Suprema de Justicia y, en orden a destacar una hipótesis de cumplimiento en este caso, se estudian las técnicas jurídicas que el derecho comparado ofrece para asegurar la eficacia inmediata de las sentencias constitucionales.La actuación inmediata de la sentencia impugnada es el derecho de orden procesal que confiere al actor la posibilidad de que se ejecute en forma anticipada la sentencia, independientemente que esta sea apelada, con el propósito de prevenir daños irreparables no evitables por vía del amparo provisional. SummaryThis text examines the situation of the Historical Archive of the National Police –[By its initials in Spanish AHPN]- from the legal optics, in reference to the constitutional action of amparo promoted by the Human Rights Ombudsman, in 2019, against the Ministry of Culture and Sports and the Ministry of the Interior. In particular, it is decided the problem related to the danger expected by the delay of the constitutional courts and the competent governmental authorities in issuing the orders and taking the measures required to prevent an irreparable situation that makes it impossible to restore things to their previous state. For this purpose, the most relevant aspects of the amparo sentence are read through, which are relapsed in the file 1281-2019 of the Supreme Court of Justice and, in order to highlight a hypothesis of compliance in this case, the legal techniques included in comparative law are studied to ensure the immediate effectiveness of constitutional sentences.The immediate action of the contested sentence is the procedural law order that gives the plaintiff the possibility of having the sentence executed in advance, regardless of whether it is appealed, with the purpose of preventing irreparable damages not avoidable by an interim amparo.
KOBİ’LERDE KURUMSAL YÖNETİM FARKINDALIĞI: VAN ORGANİZE SANAYİ BÖLGESİ ÖRNEĞİ
Authors: TATLI Uğur , ÖZTÜRKÇÜ AKÇAY Aysel 
Published: April 2022

Sürekli değişen ve artan bir rekabet ortamında KOBİ’lerin faaliyetlerini sürdürebilmeleri için hem gelişen ekonomik koşullara hem de teknolojik koşullara ayak uydurmaları gerekmektedir. Değişen ve artan bu rekabet ortamında kurumsal yönetim kavramı, son yıllarda üzerinde tartışılan ve bütün dünyada uygulanmaya çalışılan önemli bir kavram olarak karşımıza çıkmaktadır. KOBİ’lerin geleceğe yönelik endişe ve belirsizliklerinin giderilmesi, kendi yapılarından veya dış faktörlerden kaynaklanan sorunların çözümü için kurumsal yönetim anlayışının KOBİ’lerde yerleşmesi önerilmektedir.
Bu çalışmanın amacı, kurumsal yönetim anlayışının temel ilkeleri olan Adillik, Sorumluluk, Şeffaflık ve Hesap Verebilirlik çerçevesinde Van İli Organize Sanayi Bölgesinde faaliyet gösteren KOBİ’lerin kurumsal yönetim anlayışına olan algılarını incelemektedir. Ayrıca işletmelerin hukuki yapısı, işletme yöneticilerinin eğitim düzeyi, işletmelerde çalışan personel sayısı ve yöneticilerin iş tecrübelerinin bu anlayış ile ilişkisini araştırmaktır. Tesadüfi örneklem yöntemi kullanılarak ulaşılan 91 KOBİ’ye yüz yüze anket uygulaması yapılmış ve elde edilen veriler SPSS 22.0 paket programı ile analiz edilmiştir. Çalışmada güvenilirlik analizi, frekans analizleri ve Kruskal Wallis-H testinden yararlanılmıştır. Elde edilen bulgulara göre, ankete katılan işletmelerin büyük bir çoğunluğunun limited şirket olduğu ve bu işletmelerin kurumsal yönetim algılarının hukuki yapılarına, işletme yöneticisinin iş tecrübesine, eğitim durumuna ve çalıştırılan personel sayısına göre farklılaşmadığı tespit edilmiştir.
Advanced Reservoir Characterization Using Novel NMR Technology Secures Complex Carbonate Gas Condensate Pay, A Case Study Onshore Ukraine
Authors: Romero Rojas Pedro Antonio , Loraine Ramos , Tagarieva Larisa , Mehidey Serhiy , Solodkiy Yevgeniy , Iareshchenko Sergii , Ignatochkina Yulia 
Published: April 2022

Abstract
Formation evaluation in a gas condensate carbonates reservoir with high temperature and pressure is very challenging: low porosity and gas have an effect on reserve estimation and fluid typing identification. A complex of or state-of-the-art petrophysical studies were implemented for the first time in Europe in the Machukhske field in Ukraine, which helped to estimate the reservoir properties, rock quality, permeability and fluid typing of the main challenging productive carbonate reservoir of the Tournasian formation at a qualitatively new level.
The 8.5" section was drilled through the Tournasian formation with oil-based mud and a composite logging suite with high pressure and temperature (P, T) ratings was deployed. Gamma Ray, Neutron, Resistivity, Density and Formation Testing tools were run along with latest generation of multifrequency, focused Nuclear Magnetic Resonance (NMR) wireline tool. Longitudinal (T1 ) and transversal relaxation time (T2) distributions were calculated from multifrequency echo trains of raw NMR data to evaluate hydrocarbon porosity and saturations. The evaluation of T2 spectra used blind source separation driven by statistical independent component analysis (BSS-ICA), a machine learning algorithm. These results were then compared against those obtained from traditional two-dimensional NMR (2D-NMR) maps, specifically the T1T2 maps, that rely on the simultaneous inversion for T1 and T2. An adequate data acquisition sequences or logging activations ensured a suitable magnitude of the borehole signal, which enabled tool to apply long polarization times needed to detect volatile fluids. Conventional logs and core data were integrated with NMR results to minimize uncertainties, mathematical artifacts, and different effects. Rock quality indicators based on NMR porosity fractions and acoustic velocities were calculated and revealed some rock heterogeneities or porosity-lithology facies.
In challenging borehole condition with high P & T, high quality composite logging suite data was successfully obtained. An advanced reservoir characterization study was performed by integrating the NMR data with conventional logs which also helped to reduce the uncertainty in formation evaluation by clearly identifying pay and shale zones, deeper understanding of the storage and flow capacity of reservoir and the furthermore, providing necessary parameters for optimizing completion design.
An innovative study was carried out which helped not only meet objective of the well, but also results became reference for detailing the geological and hydrodynamic models of Machukske gas condensate field. The geological and technological model of the field was updated, and further field development strategies were optimized.
Review of Hydrodynamic Coefficients for Riser Design
Authors: Deka Dhyanjyoti , Campbell Mike , Darilmaz Ilkay , Hodges Stephen 
Published: April 2022

Abstract
A literature review of experimental and computational hydrodynamic research is presented with the objective of highlighting the parameters that affect riser added mass coefficient (Ca) and drag coefficient (Cd). Typical riser analysis is conducted assuming constant values of hydrodynamic coefficients. However, depending on the flow regime, the hydrodynamic coefficients can vary significantly, and hence using the most conservative values in all analyses can result in overly conservative riser responses. For example, the appropriate coefficients for a steady current on the straked portion of a riser near the surface may be very different from those for small oscillatory motions of the riser near the Touch Down Point (TDP). Several opportunities of reducing conservatism are presented based on using variable hydrodynamic coefficient-based analysis.
Hydrodynamic coefficients are dependent on surface roughness, nature of the flow (steady vs. unsteady) and presence of Vortex Induced Vibration (VIV) suppression devices (strakes or fairings), among other factors. Relevant and important bodies of work as documented in papers, test reports or doctoral theses in the public domain are used to determine sensitivity of Cd and Ca values to Reynold's number (Re) and the Keulegan Carpenter (Kc) number. Steady and unsteady flows are treated separately, as are unstraked (bare) and straked pipes.
The practice of using constant values of hydrodynamic coefficients in riser analysis is simplistic and often overly conservative. A common practice is to use Cd of 0.7 in bare pipe fatigue analysis as a lower bound. Several tests have demonstrated that Cd can in fact lie in the 1 – 2 range depending on Kc number and Re number. Higher Cd is associated with higher hydrodynamic damping and considerable improvement in TDP fatigue life prediction. Similarly, strake Cd's in low Kc flow have also been observed to be higher than what is used in typical riser analysis, sometimes by a factor of 3 or more. On the other hand, higher Ca values can lead to higher fatigue damage prediction. The correct input of Ca is thus essential to avoid being under conservative. Ca variations with respect to Kc number for both bare and straked pipes are provided in this paper.
A refined approach to application of hydrodynamic coefficients in riser analysis is necessary to avoid over or under conservatism. This is especially important in life extension studies where there is little room for additional conservatism. The riser design codes typically do not provide an in-depth review of hydrodynamic coefficients based on factors such as roughness, nature of flow or pipe cross section. This review paper of fundamental experimental and computational work on hydrodynamic parameters is a useful reference to be used in design and life extension assessments.
Subsea Robotics - AUV Pipeline Inspection Development Project
Authors: Andy Gower Stephen , Mathieu Lardeux , Bill Gilmour , Damian Ling 
Published: April 2022

Abstract
Early in 2014, TotalEnergies E&P, Chevron ETC, and Oceaneering Subsea Robotics (SSR) (Formerly C&C Technologies) came to an agreement to jointly develop an Autonomous Underwater Vehicle, AUV, system capable of performing complete AUV pipeline inspection for deepwater pipelines. The main goal of this project is to deliver improved operational efficiency and data quality compared to that provided by conventional Remotely Operated Vehicle, ROV, inspection. This development has been promoted to avoid high costs and improve on the low inspection speeds of tools such as ROV and Remotely Operated Towed Vehicles, ROTV, with associated expensive vessel spreads, particularly in deep water. To meet this goal numerous AUV associated technologies were developed such as: autonomous pipeline tracking, feature-based navigation, improved sensors for data collection, obstacle avoidance systems and other adaptive-behavior functionalities.
The results of the combined development & trials conducted between 2014 – 2018 progressed the vehicle software development and identified the limitations of adapting current vehicle design. Capitalizing on these results, later in 2019 a new purpose-built vehicle solution was introduced with enhanced command and control capabilities, intending to significantly improve vehicle performance to achieve the intended results. The development and acceptance of the functionality applied: scaled and prototype testing, use of a realistic test environment in shallow water, software simulation and a focus on achieving a satisfactory level of reliability of the behaviors.
In this paper, qualification process and data is presented associated with the performance of the vehicle observed during an Offshore Pilot, conducted in Q3 2021 in the North Sea, using operational pipelines. The demonstration of reliable adaptive behaviors and functionality will enable the acceptance of this new technology through the qualification process. This will lead to AUV's becoming the industry standard for future pipeline inspection campaigns and achieve a milestone towards resident applications.
Application of Artificial Intelligence to Upscale High-Fidelity Models Considering Fluids Profiles
Authors: Scanavini Helena F. A. , Santos Anderson , Pedrini Helio , Schiozer Denis José , Munerato Fernando P. , Barreto Carlos Eduardo A. G. 
Published: April 2022

Abstract
Upscaling of highly heterogeneous reservoirs is a challenging task due to reservoir simulation of lower resolution scale geological models may present poor quality production indicators. The solution to this type of problem lies in a better calculation of some non-additive geological properties, such as permeability. In recent years, there has been a growth in the development and accuracy of artificial intelligence methods, which can be an important key to the quality of the models, given that AI helps with problems with a high quantity of information. The objective of this work is to evaluate a machine learning-based approach to upscale complex model permeabilities, so that it better captures the global dynamical behavior of different fluids, such as oil, water, and gas. The proposed method uses recent artificial intelligence concepts of machine-learning and optimization to correct the reservoir upscaling in the case of multiple uncertainties resolutions while creating better coarse models whose dynamical behavior honors the fine model. The methodology was adequate and captured the global dynamical behavior of the reservoir. It was able to improve the coarser simulation model results, especially for oil and gas production forecasts, when considering the oil and field results in the AI training.