bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bibliometric study of soluble guanylate cyclase stimulators in cardiovascular research based on web of science from 1992 to 2021
Authors: Jia Xiao-Yan , Liu Yong-Ming , Wang Yong-Fei , An Jin-Yang , Peng Ke-Ling , Wang Hua 
Published: August 2022

Background: Several studies have shown that soluble guanylate cyclase (sGC) stimulators have cardiovascular (CV) benefits. However, few bibliometric analyses have examined this field systematically. Our study aimed to examine the publications to determine the trends and hotspots in CV research on sGC stimulators.Methods: Publications on sGC stimulators in CV research were retrieved from the Web of Science Core Collection. VOSviewer and CiteSpace visualization software were used to analyze publication trends, countries (regions) and institutions, journals and cited journals, authors and cited references, as well as keywords.Results: A total of 1,212 literatures were obtained. From its first appearance in 1992–2021 (based on WOSCC record), the overall volume of publications has shown a gradual increasing trend. Nearly one-third were authored by American scholars, and most were published in Circulation, Circulation Research, and Proceedings of the National Academy of Sciences of the United States of America. Bayer Agency in Germany was the leading driving force, and has a high academic reputation in this field. Stasch JP has published the most related articles and been cited most frequently. Half of the top 10 co-cited references were published in the leading highly co-cited journal Circulation and New England Journal of Medicine. “NO,” “allosteric regulation” and “free radicals” were the focus of previous research, “chronic thromboembolic pulmonary hypertension,” “pulmonary hypertension” and “heart failure” were the main research hotspots. The key words “chronic thromboembolic pulmonary hypertension,” “Pulmonary hypertension,” “preserved ejection fraction” and “heart failure” appeared most recently as research frontiers.Conclusion: The research in the CV field of sGC stimulators was relatively comprehensive, and there was a close relationship among countries, research institutions and authors, but it is still in the exploratory stage in the treatment of CV disease. At present, most studies focus on the results of clinical trials. sGC stimulators in the treatment of heart failure, especially heart failure with preserved ejection fraction, may be the hotpots and Frontier at present and in the future, and should be closely monitored.
Paeoniflorin alleviates liver injury in hypercholesterolemic rats through the ROCK/AMPK pathway
Authors: Liu Tong , Zhang Ning , Kong Lingya , Chu Sijie , Zhang Ting , Yan Guangdi , Ma Donglai , Dai Jun , Ma Zhihong 
Published: August 2022

Paeoniflorin (PF) is the main active component in Paeonia lactiflora Pall, and it has multiple effects. However, the precise mechanism of PF in hypercholesterolemia is unclear. In this study, rats were either fed a high-cholesterol diet (HCD) for 4 weeks to establish the hypercholesterolemic model or administered normal saline or PF (20 mg/kg/day). PF significantly reduced liver weight and the liver index. PF reduced hepatic lipid deposition and inflammation, improved serum lipid metabolism, and significantly inhibited serum and hepatic oxidative stress and the inflammatory response. PF treatment caused a marked decrease in the phosphorylated myosin phosphatase target subunit (p-MYPT)-1, nuclear sterol regulatory element-binding protein-1c (SREBP-1c), fatty acid synthase (FAS) levels, and an increase in the low-density lipoprotein receptor (LDLR) and phosphorylated-AMP-activated protein kinase (p-AMPK). Thus, PF could alleviate liver injury in hypercholesterolemic rats, and the specific mechanism may be related to the antioxidant, anti-inflammatory properties, and ROCK/AMPK/SREBP-1c signaling pathway.
CortexVR: Immersive analysis and training of cognitive executive functions of soccer players using virtual reality and machine learning
Authors: Krupitzer Christian , Naber Jens , Stauffert Jan-Philipp , Mayer Jan , Spielmann Jan , Ehmann Paul , Boci Noel , Bürkle Maurice , Ho André , Komorek Clemens , Heinickel Felix , Kounev Samuel , Becker Christian , Latoschik Marc Erich 
Published: August 2022

GoalThis paper presents an immersive Virtual Reality (VR) system to analyze and train Executive Functions (EFs) of soccer players. EFs are important cognitive functions for athletes. They are a relevant quality that distinguishes amateurs from professionals.MethodThe system is based on immersive technology, hence, the user interacts naturally and experiences a training session in a virtual world. The proposed system has a modular design supporting the extension of various so-called game modes. Game modes combine selected game mechanics with specific simulation content to target particular training aspects. The system architecture decouples selection/parameterization and analysis of training sessions via a coaching app from an Unity3D-based VR simulation core. Monitoring of user performance and progress is recorded by a database that sends the necessary feedback to the coaching app for analysis.ResultsThe system is tested for VR-critical performance criteria to reveal the usefulness of a new interaction paradigm in the cognitive training and analysis of EFs. Subjective ratings for overall usability show that the design as VR application enhances the user experience compared to a traditional desktop app; whereas the new, unfamiliar interaction paradigm does not negatively impact the effort for using the application.ConclusionThe system can provide immersive training of EF in a fully virtual environment, eliminating potential distraction. It further provides an easy-to-use analyzes tool to compare user but also an automatic, adaptive training mode.
Nurse champions as street-level bureaucrats: Factors which facilitate innovation, policy making, and reconstruction
Authors: Sperling Daniel , Shadmi Efrat , Drach-Zahavy Anat , Luz Shirly 
Published: August 2022

BackgroundNurse champions are front-line practitioners who implement innovation and reconstruct policy.PurposeTo understand through a network theory lens the factors that facilitate nurse champions’ engagement with radical projects, representing their actions as street-level bureaucrats (SLBs).Materials and methodsA personal-network survey was employed. Ninety-one nurse champions from three tertiary medical centers in Israel participated.FindingsGiven high network density, high levels of advice play a bigger role in achieving high radicalness compared with lower levels advice. High network density is also related to higher radicalness when networks have high role diversity.DiscussionUsing an SLB framework, the findings suggest that nurse champions best promote adoption of innovation and offer radical changes in their organizations through professional advice given by colleagues in their field network. Healthcare organizations should establish the structure and promote the development of dense and heterogeneous professional networks to realize organizations’ goals and nurses’ responsibility to their professional employees, patients, and society.
Depression is differentially related to cognitive and biomarker outcomes among Mexican Americans
Authors: O’Bryant Sid E. , Petersen Melissa , Hall James , Johnson Leigh A. 
Published: August 2022

IntroductionDespite tremendous advancements in the research of Alzheimer’s disease (AD), Mexican Americans, who reflect 65% of the US Hispanic community, remain severely underrepresented in research. Our data demonstrate that risk factors for, and biomarkers of, AD are different among Mexican Americans as compared with non-Hispanic whites. Here, we examined the impact of depressive symptoms on cognitive and AD-relevant biomarker outcomes among the Mexican Americans.MethodsData were examined from 1,633 (852 Mexican Americans and 781 non-Hispanic whites) of the Health and Aging Brain Study–Health Disparities (HABS–HD). Depression was assessed using the Geriatric Depression Scale while cognition was measured using detailed neuropsychological testing. Plasma biomarkers of Aβ40, Aβ42, total tau, and NfL were examined in addition to MRI-based neurodegeneration. PET amyloid data were available in a subset of participants.ResultsDepressive symptoms were significantly associated with cognitive testing results among both Mexican Americans and non-Hispanic whites. However, depression was only significantly associated with cognitive outcomes and plasma biomarkers among the Mexican American APOEε4 non-carriers.DiscussionDepressive symptoms are more commonly endorsed by Mexican Americans and these symptoms are more strongly associated with cognitive and AD-biomarker outcomes among this ethnic group. However, depression scores were only related to AD outcomes among APOEε4 non-carriers within the Mexican American group. These findings can aid in the development of a population-informed precision medicine for treating and preventing cognitive loss among the Mexican Americans.
Development of a culturally adaptable internet-based cognitive behavioral therapy for Japanese women with bulimia nervosa
Authors: Hamatani Sayo , Matsumoto Kazuki , Ishibashi Tomoaki , Shibukawa Ryunosuke , Honda Yuki , Kosaka Hirotaka , Mizuno Yoshifumi , Andersson Gerhard 
Published: August 2022

BackgroundThe process of cultural adaptation of internet-based cognitive behavioral therapy (ICBT) programs for bulimia nervosa (BN) have rarely been reported despite the potential influence of cultural adaptation of psychosocial interventions on therapeutic response.AimThis study aimed to illustrate development process of an ICBT program for Japanese women with bulimia nervosa (BN).MethodsA mixed methods approach was used to assess cultural adaptation of the prototype of an original ICBT program by using the Cultural Relevance Questionnaire (CRQ). Five women with BN and seven clinicians were interviewed using the CRQ.ResultsQuantitative analyses were conducted to assess cultural adaptation of the prototype of the program and participants rated cultural adaptation as high. A qualitative analysis of the mixed method supported the culturally sensitive changes implemented.ConclusionsThe results of this study show that a series of processes can make ICBT programs more culturally adapted.
The effect of a short, animated story-based video on COVID-19 vaccine hesitancy: A study protocol for an online randomized controlled trial
Authors: Barteit Sandra , Hachaturyan Violetta , Beleites Ferdinand , Kühn Tilman , Favaretti Caterina , Adam Maya , Bärnighausen Till 
Published: August 2022

IntroductionExposure to a high volume of vaccine misinformation on social media can have a negative effect on vaccine confidence and rates. To counteract misinformation, we designed a collage of three short, animated story-based (SAS) videos to convey scientifically informed and accessible information about COVID-19 vaccine applicable to a social media context.Methods and analysisWe will conduct an online randomized controlled trial primarily to: (1) determine the effectiveness of SAS videos in improving COVID-19 vaccine knowledge; (2) evaluate the effectiveness of SAS videos in increasing behavioral intent for COVID-19 vaccination; and (3) quantify people's interest in watching SAS videos about the COVID-19 vaccine. We also aim to identify barriers and facilitators to COIVD-19 vaccinations that have been shown to minimize vaccine hesitancy between vaccinated and unvaccinated populations. Using a web-based recruitment platform, a total of 10,000 adults from the United States will be recruited and randomly assigned to (1) a SAS video collage arm, (2) an attention placebo control video arm, or (3) no intervention arm (1:1:1). Furthermore, we will measure behavioral intent to obtain information on vaccination regarding COVID-19. At the end of the trial, participants randomized to arm 2 and arm 3 will be given the option of watching one of the intervention videos voluntarily to assess participant engagement with SAS videos. Finally, we will assess individual factors associated with vaccine hesitancy - hope, optimism, COVID-19 perceived risks and benefits, self-efficacy, perceived social norms, and trust - and compare vaccinated and unvaccinated participants across the three arms.DiscussionsEvidence-based information from official channels can be complex and inaccessible to the general public, whereas false information on social media is frequently shared in brief postings, images, or videos that can easily reach the general public, thereby rapidly disseminating (mis-)information. To avoid the spread of misinformation, social media may be used to deliver evidence-based and emotionally compelling information in a readily accessible format in order to pre-empt misinformation. Our findings may help inform future SAS efforts addressing COVID-19 and other important public health challenges.Ethics and disseminationThe study was approved by the Heidelberg University Hospital's Ethics Committee (S-163/2022). The trial was registered with German Clinical Trials Register (www.drks.de) on 5 January 2022: number DRKS00027938. Findings of the study will be published in peer-reviewed scientific publications and possibly presented at scientific conferences.
A novel web-based dynamic nomogram for recurrent laryngeal nerve lymph node metastasis in esophageal squamous cell carcinoma
Authors: Chen Ting-Ting , Yan Hao-Ji , He Xi , Fu Si-Yi , Zhang Sheng-Xuan , Yang Wan , Zuo Yu-Jie , Tang Hong-Tao , Yang Jun-Jie , Liu Pei-Zhi , Wen Hong-Ying , Tian Dong 
Published: August 2022

BackgroundPatients with esophageal squamous cell carcinoma (ESCC) are liable to develop recurrent laryngeal nerve (RLN) lymph node metastasis (LNM). We aimed to assess the predictive value of the long diameter (LD) and short diameter (SD) of RLN lymph node (LN) and construct a web-based dynamic nomogram for RLN LNM prediction.MethodsWe reviewed 186 ESCC patients who underwent RLN LN dissection from January 2016 to December 2018 in the Affiliated Hospital of North Sichuan Medical College. Risk factors for left and right RLN LNM were determined by univariate and multivariate analyses. A web-based dynamic nomogram was constructed by using logistic regression. The performance was assessed by the area under the curve (AUC) and Brier score. Models were internally validated by performing five-fold cross-validation.ResultsPatients who underwent left and right RLN LN dissection were categorized as left cohort (n = 132) and right cohort (n = 159), with RLN LNM rates of 15.9% (21/132) and 21.4% (34/159), respectively. The AUCs of the LD (SD) of RLN LN were 0.663 (0.688) in the left cohort and 0.696 (0.705) in the right cohort. The multivariate analysis showed that age, the SD of RLN LN, and clinical T stage were significant risk factors for left RLN LNM (all P &lt; 0.05), while tumor location, the SD of RLN LN, and clinical T stage were significant risk factors for right RLN LNM (all P &lt; 0.05). The dynamic nomograms showed reliable performance after five-fold cross-validation [(left (right), mean AUC: 0.814, range: 0.614–0.891 (0.775, range: 0.084–0.126); mean Brier score: 0.103, range: 0.084–0.126 (0.145, range: 0.105–0.206)], available at https://mpthtw.shinyapps.io/leftnomo/ and https://mpthtw.shinyapps.io/rightnomo/.ConclusionThe LD and SD of RLN LN are inadequate to predict RLN LNM accurately, but online dynamic nomograms by combined risk factors show better prediction performance and convenient clinical application.
A potential herbal therapeutic for trichinellosis
Authors: El-kady Asmaa M. , Abdel-Rahman Iman A. M. , Sayed Eman , Wakid Majed H. , Alobaid Hussah M. , Mohamed Khalil , Alshehri Eman Abdullah , Elshazly Hayam , Al-Megrin Wafa Abdullah I. , Iqbal Furhan , Elshabrawy Hatem A. , Timsah Ashraf G. 
Published: August 2022

BackgroundTrichinellosis is a helminthic disease caused byTrichinella spiralis viathe ingestion of raw or undercooked meat of infected animals. Current estimates indicate that 11 million humans have trichinellosis, worldwide. The effective use of anti-trichinella medications is limited by side effects and resistance which highlight the critical need for safe and effective drugs, particularly those derived from medicinal plants. Therefore, in the present study, we aimed to evaluate the efficacy of the ethanolic extract ofArtemisia annua(A. annua) in treatment of experimentally induced trichinellosis.Materials and methodsTrichinellosis was induced experimentally in male 6–8 weeks BALB/c mice. BALB/c mice were divided into four groups, 10 mice each. One group was left uninfected and untreated, whereas three groups were infected withT. spiralis. Oneinfected group of mice was left untreated (negative control) while the remaining two infected groups received either 300 mg/kg of the ethanolic extract ofA. annuaor 50 mg/kg of albendazole (positive control). All treatments started from the third day post-infection (dpi) for 3 successive days. All animals were sacrificed on the 7th dpi for evaluation of treatment efficacy.ResultsOur findings showed thatA. annuatreatment reduced theT. spiralisadult-worm count in the intestine of infected animals. Moreover, treatment withA. annuarestored the normal intestinal architecture, reduced edema, alleviated inflammation as demonstrated by reduced inflammatory infiltrate and expression of TGF-β in intestinal tissues ofA. annua-treated animals compared to infected untreated animals.ConclusionsOur findings show thatA. annuaextract is effective in treating experimentally induced trichinellosis which highlight the therapeutic potential ofA. annuafor intestinal trichinellosis.
« Mes archives sont-elles queer ? » : des demandes d’archivage et de communication spécifiques aux militantes et militants féministes et queer
Authors: Grailles Bénédicte 
Published: August 2022

Entre les activistes féministes et queer et les archivistes de métier existent de nombreux malentendus, à commencer par des définitions différentes du périmètre des archives – pour les premiers, fonds documentaires, fonds d’archives et collections muséales tout à la fois, là où pour les seconds prévaut une conception résolument organique –, une appréhension contrastée de la fonction archivistique – pour les premiers, un instrument de pouvoir et d’exposition qui amène à constater, dans la lignée de Derrida, l’existence d’une violence institutionnelle exercée sur les traces que les seconds ne perçoivent pas dans la mise en oeuvre de leurs pratiques professionnelles. Pour mieux appréhender les enjeux, il faut s’intéresser aux logiques d’usage des activistes : des logiques de construction identitaire personnelle et de réassurance de soi («je suis » ), des logiques de constructions identitaires collectives («nous sommes » ), des logiques d’affiliation («nous sommes ensemble » ), des logiques de visibilisation dans l’espace public («nous existons » ). C’est pourquoi la question de la maîtrise de la chaîne de sélection, de conservation et de diffusion des archives féministes et
queer est centrale. L’objet de cet article, tout en insistant sur la valeur performative des archives, est de proposer de ré-examiner certains principes théoriques et pratiques des archivistes de métier. Que peuvent-ils apporter qui puisse être reçu ? Les modalités et les critères de production de l’évaluation archivistique, le mandat que l’institution archivistique affirme pour elle-même, la prise en compte de la mixité entre le personnel et le public, l’ouverture à des pratiques non expertes, la mise en oeuvre de lieux ou d’événements co-construits, mais aussi la réalisation de collectes nouvelles – dépôt de capsules temporelles et enregistrement de documents «performés » – sont autant d’éléments susceptibles de réenchanter la pratique archivistique.
Educação em saúde com crianças indígenas em meio a pandemia COVID-19: relato de experiência
Authors: Lemos Larissa Barbosa , Lima Eurides Souza de , Costa Lana Alfaia da , Braga Lidiane Mendonça , Costa Lucas Farias da , Rocha Verônica Holanda da Silva , Oliveira Bruna Soraya da Silva Barbosa , Coimbra Natália da Silva 
Published: August 2022

A educação em saúde é vista como o processo educativo de criação de conhecimentos em saúde com o objetivo de aumentar a autonomia das pessoas no autocuidado. A atenção à saúde da criança indígena tem como prioridade a proteção, prevenção e promoção de agravos por meio da implementação de políticas e programas focando na melhoria das condições socioculturais, ambientais e de saúde, levando em conta suas as variadas culturas existentes (BORGES & DE OLIVEIRA, 2016). Trata-se de um estudo descritivo do tipo relato de experiência desenvolvida com base na visita acadêmica a uma aldeia indígena da etnia Sateré Mawé.
Estudo analítico dos casos de Tuberculose no município de Itaperuna-RJ de 2012 a 2021
Authors: Cabral Kamila Campos , Arruda Jéssica de Abreu , Britto Guilherme Pegoraro Carneiro de , Jacob Izabelle , Oliveira Sara Campos de , Boniolo Victória Figueiredo , Boechat Matheus Alves Monteiro de Paula , Martins Manoela de Pereira 
Published: August 2022

Introdução: A tuberculose é uma infecção bacteriana transmitida através da inalação de gotículas de uma pessoa infectada pela bactéria chamada de Mycobacterium tuberculosis. Esta doença é a principal causa de morte por uma doença infecciosa entre adultos em todo o mundo e tem sido considerada uma emergência global de saúde pública. Objetivo: O objetivo deste estudo consiste em analisar os casos de tuberculose no município em questão em relação aos vários aspectos epidemiológicos da doença a fim de estabelecer vínculo entre a etiologia e promoção de saúde. Metodologia: Este artigo refere-se a um estudo transversal, realizado no período compreendido entre maio de 2022 a agosto de 2022. A base de dados “DATASUS” foi utilizada para a coleta de dados estatísticos e foi efetuada uma busca bibliográfica nas bases de dados PubMed, Medline e SciELO. As palavras-chave utilizadas foram “tuberculose” e “epidemiologia da tuberculose” nos idiomas português e inglês. Desenvolvimento e Conclusão: No período estudado, em Itaperuna-RJ, foi possível constatar que a tuberculose atingiu em maior proporção a população em idade adulta-jovem com prevalência no sexo masculino. Quanto aos fatores de riscos discutidos, verificou-se que estavam de acordo com a tendência global. A taxa de letalidade pela doença no município foi menor do que a encontrada em outros lugares no Brasil e no Mundo, o que mostra uma efetividade no tratamento e acompanhamento da doença pelos serviços de saúde da região.
First-principles calculations of Schottky barrier height at barium titanate/metal interface
Authors: Suemasa Riki , Sakai Yuki , Araki Masahiko , Masuda Hidetoshi , Shimomai Kenichi , Kaneda Kazumi , Iwazaki Yoshiki 
Published: August 2022

Abstract
The Schottky barrier (SB) height at insulator/metal interfaces is important for a wide variety of electronic devices. We performed first-principles analysis of the SB formed between BaTiO3 (BTO) and metals with a cubic crystal structure. We found that the barrier height strongly depends on the contact metal and the BTO termination surface. These results were quantitatively understood by analyzing the contributions of the atomic and charge rearrangement at the interfaces. It was also found that when a different metal is substituted for one of the monoatomic Ni layers at the BTO/Ni interface, the SB is significantly influenced by the nature of the substituting metal.