bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dual contribution of the gut microbiome to immunotherapy efficacy and toxicity: supportive care implications and recommendations
Authors: Wardill Hannah R. , Chan Raymond J. , Chan Alexandre , Keefe Dorothy , Costello Samuel P. , Hart Nicolas H. 
Published: March 2022

Abstract
The efficacy of immune checkpoint inhibitors (immunotherapy) is increasingly recognized to be linked to the composition the gut microbiome. Given the high rates of resistance, interventions targeting the gut microbiome are now being investigated for its ability to improve the efficacy of immunotherapy. In light of recently published data demonstrating a strong correlation between the efficacy and toxicity of immunotherapy, there is a risk that efforts to enhance immunotherapy efficacy may be undermined by increases in immune-related adverse events (IrAEs) This is particularly important for microbial interventions aimed at increasing immunotherapy efficacy, with many microbes implicated in tumour response also linked to IrAEs, especially colitis. IrAEs have a profound impact on patient quality of life, causing physical, psychosocial, and financial distress. Here, we outline strategies at the discovery, translational, and clinical research phases to ensure the impact of augmenting immunotherapy efficacy is approached in a manner that considers adverse implications. Adopting these strategies will ensure that our ongoing efforts to overcome immunotherapy resistance are not impacted by unacceptable toxicity.
Interkommunale Kooperationen als Voraussetzung für den Ausbau von Bioenergiepotenzialen und der Gestaltung kommunaler Wärmewende
Authors: Baasch Stefanie , Lenz Christine 
Published: March 2022

ZusammenfassungBioenergie ist im Rahmen einer nachhaltigen Energiewende von zentraler Bedeutung. Im Vergleich zu anderen erneuerbaren Energieträgern bietet Biomasse den Vorteil, dass sie fossile Brennstoffe direkt ersetzen und bei Bedarf für die Umwandlung in Wärme, Strom und Kraftstoffe gespeichert werden kann. Dementgegen stehen erhebliche Nutzungs- und Flächenkonflikte des Energiepflanzenanbaus und ein seit 2014 stagnierender Ausbau von Biogasanlagen. Als konfliktärmere Alternative gilt die reststoffbasierte Bioenergieerzeugung in Kombination mit dezentralen Nutzungsstrategien, diese stößt in der Praxis allerdings auf erhebliche Umsetzungsbarrieren. Dieser Beitrag stellt Ergebnisse eines transdiziplinären Verbundforschungsprojekts vor, welches in Nordhessen kommunale und regionale Handlungsoptionen für eine optimierte energetische Bioenergieerzeugung untersucht hat. Zentrale Erkenntnisse zeigen, dass eine verlässliche Bewertung von Biomassepotenzialen die Einbeziehung von regionalen Wissensbeständen erforderlich macht. Ein erheblicher Anteil der regionalen Biomassepotenziale ist derzeit in stark fragmentierten Nutzungspfaden gebunden, die allerdings aus ökologischer Perspektive und vor dem Hintergrund steigender CO2-Bepreisung einer Überprüfung bedürfen. Für eine Optimierung von Biomassenutzungspfaden zeichnet sich ab, dass vielversprechende Ansätze vor allem durch interkommunale Kooperationen erreicht werden können.
Symplectic geometry of Cartan–Hartogs domains
Authors: Mossa Roberto , Zedda Michela 
Published: March 2022

AbstractThis paper studies the geometry of Cartan–Hartogs domains from the symplectic point of view. Inspired by duality between compact and noncompact Hermitian symmetric spaces, we construct a dual counterpart of Cartan–Hartogs domains and give explicit expression of global Darboux coordinates for both Cartan–Hartogs domains and their dual. Further, we compute their symplectic capacity and show that a Cartan–Hartogs domain admits a symplectic duality if and only if it reduces to be a complex hyperbolic space.
Double-calibration estimators accounting for under-coverage and nonresponse in socio-economic surveys
Authors: Dickson Maria Michela , Espa Giuseppe , Fattorini Lorenzo , Santi Flavio 
Published: March 2022

AbstractUnder-coverage and nonresponse problems are jointly present in most socio-economic surveys. The purpose of this paper is to propose an estimation strategy that accounts for both problems by performing a two-step calibration. The first calibration exploits a set of auxiliary variables only available for the units in the sampled population to account for nonresponse. The second calibration exploits a different set of auxiliary variables available for the whole population, to account for under-coverage. The two calibrations are then unified in a double-calibration estimator. Mean and variance of the estimator are derived up to the first order of approximation. Conditions ensuring approximate unbiasedness are derived and discussed. The strategy is empirically checked by a simulation study performed on a set of artificial populations. A case study is derived from the European Union Statistics on Income and Living Conditions survey data. The strategy proposed is flexible and suitable in most situations in which both under-coverage and nonresponse are present.
Zines as community archive
Authors: Baker Sarah , Cantillon Zelmarie 
Published: March 2022

AbstractZines are self-published, do-it-yourself booklets that have a long history as tools for activism in social movements. While archival studies has already explored the collection and preservation of zines as cultural artefacts, this article explores the capacity for zines to act as a form of community archive. The article examines See You at the Paradise, a zine co-created with Norfolk Island community members for a research project focused on Kingston and Arthur’s Vale Historic Area. Drawing on Michelle Caswell’s six principles of community archive discourse—participation, shared stewardship, multiplicity, activism, reflexivity, valuing affect—we analyse the extent to which zines and zine-making, as product and process, can be understood as community archive. In doing so, we propose collaborative reminiscence as a seventh principle. The article finds that zines, as community archive, work to strengthen the presence of marginalised voices in dominant historical narratives while also offering an important resource for community-building and political resistance.
Is Empathy the Key to Effective Teaching? A Systematic Review of Its Association with Teacher-Student Interactions and Student Outcomes
Authors: Aldrup Karen , Carstensen Bastian , Klusmann Uta 
Published: March 2022

AbstractTeachers’ social-emotional competence has received increasing attention in educational psychology for about a decade and has been suggested to be an important prerequisite for the quality of teacher-student interactions and student outcomes. In this review, we will summarize the current state of knowledge about the association between one central component of teachers’ social-emotional competence—their empathy—with these indicators of teaching effectiveness. After all, empathy appears to be a particularly promising determinant for explaining high-quality teacher-student interactions, especially emotional support for students and, in turn, positive student development from a theoretical perspective. A systematic literature research yielded 41 records relevant for our article. Results indicated that teachers reporting more empathy with victims of bullying in hypothetical scenarios indicated a greater likelihood to intervene. However, there was neither consistent evidence for a relationship between teachers’ empathy and the degree to which they supported students emotionally in general, nor with classroom management, instructional support, or student outcomes. Notably, most studies asked teachers for a self-evaluation of their empathy, whereas assessments based on objective criteria were underrepresented. We discuss how these methodological decisions limit the conclusions we can draw from prior studies and outline perspective for future research in teachers’ empathy.
Treatment of vascular graft infections: gentamicin-coated ePTFE grafts reveals strong antibacterial properties in vitro
Authors: Lazic Igor , Obermeier Andreas , Dietmair Bettina , Kempf Wolfgang E. , Busch Albert , Tübel Jutta , Schneider Jochen , von Eisenhart-Rothe Rüdiger , Biberthaler Peter , Burgkart Rainer , Pförringer Dominik 
Published: March 2022

AbstractVascular graft infections (VGI) are severe complications in prosthetic vascular surgery with an incidence ranging from 1 to 6%. In these cases, synthetic grafts are commonly used in combination with antimicrobial agents. Expanded polytetrafluoroethylene (ePTFE) is in clinical use as a synthetic graft material and shows promising results by influencing bacterial adhesion. However, the literature on antibiotic-bound ePTFE grafts is scarce. Gentamicin is a frequently used antibiotic for local treatment of surgical site infections, but has not been evaluated as antimicrobial agent on ePTFE grafts. In this study, we examine the antimicrobial efficacy and biocompatibility of novel types of gentamicin-coated ePTFE grafts in vitro. ePTFE grafts coated with gentamicin salt formulations with covalently-bound palmitate were evaluated in two drug concentrations (GP1.75% and GP3.5%). To investigate effects from types of formulations, also suspensions of gentamicin in palmitate as well as polylactide were used at comparable levels (GS + PA and GS + R203). Antibacterial efficacies were estimated by employing a zone of inhibition, growth inhibition and bacterial adhesion assay againstStaphylococcus aureus(SA). Cytotoxicity was determined with murine fibroblasts according to the ISO standard 10993-5. Gentamicin-coated ePTFE grafts show low bacterial adherence and strong antibacterial properties in vitro against SA. Bactericidal inhibition lasted until day 11. Highest biocompatibility was achieved using gentamicin palmitate GP1.75% coated ePTFE grafts. ePTFE grafts with gentamicin-coating are effective in vitro against SA growth and adherence. Most promising results regarding antimicrobial properties and biocompatibility were shown with chemically bounded gentamicin palmitate GP1.75% coatings.
Three-dimensional printing of polycaprolactone/hydroxyapatite bone tissue engineering scaffolds mechanical properties and biological behavior
Authors: Rezania Naghme , Asadi-Eydivand Mitra , Abolfathi Nabiollah , Bonakdar Shahin , Mehrjoo Morteza , Solati-Hashjin Mehran 
Published: March 2022

AbstractControlled pore size and desirable internal architecture of bone scaffolds play a significant role in bone regeneration efficiency. In addition to choosing appropriate materials, the manufacturing method is another significant factor in fabricating the ideal scaffold. In this study, scaffolds were designed and fabricated by the fused filament fabrication (FFF) technique. Polycaprolactone (PCL) and composites films with various percentages of hydroxyapatite (HA) (up to 20%wt) were used to fabricate filaments. The influence of (HA) addition on the mechanical properties of filaments and scaffolds was investigated. in vitro biological evaluation was examined as well as the apatite formation in simulated body fluid (SBF). The addition of HA particles increased the compressive strength and Young’s modulus of filaments and consequently the scaffolds. Compared to PCL, Young’s modulus of PCL/HA20% filament and three-dimensional (3D) printed scaffold has increased by 30% and 50%, respectively. Also, Young’s modulus for all scaffolds was in the range of 30–70 MPa, which is appropriate to use in spongy bone. Besides, the MTT assay was utilized to evaluate cell viability on the scaffolds. All the samples had qualified cytocompatibility, and it would be anticipated that addition of HA particles raise the biocompatibility in vivo. Alkaline phosphatase (ALP) evaluation shows that the addition of HA caused higher ALP activity in the PCL/HA scaffolds than PCL. Furthermore, calcium deposition in the PCL/HA specimens is higher than control. In conclusion, the addition of HA particles into the PCL matrix, as well as utilizing an inexpensive commercial FFF device, lead to the fabrication of scaffolds with proper mechanical and biological properties for bone tissue engineering applications.
Hybrid NOMA-based ACO-FBMC/OQAM for next-generation indoor optical wireless communications using LiFi technology
Authors: Hesham Hamis , Ismail Tawfik 
Published: March 2022

AbstractLight fidelity (LiFi) has successfully achieved high data transfer rates, high security, great availability, and low interference. In this paper, we propose a LiFi system consisting of a combination of non-orthogonal multi-access (NOMA), asymmetrically-clipped optical (ACO), and filter bank multicarrier (FBMC) techniques combined with offset quadrature amplitude modulation (OQAM). The paper also applies a $$\mu $$
μ
-law companding approach for a high peak to average power ratio (PAPR) reduction of the FBMC/OQAM scheme. The combination of NOMA, ACO-FBMC/OQAM, and $$\mu $$
μ
-law companding allows a significant increase in throughput and a significant reduction in unserved users. Considering two scenarios, an appropriate algorithm is developed to maximize the throughput and minimize the number of blocked (unserved) users. The results show that the overall system throughput could be increased by 1.8 compared to FBMC, OFDM, and OFDM-NOMA. Furthermore, the proposed system reduces the number of unserved users below $$10\%$$

10
%

, while the system can provide 30 or $$60\%$$

60
%

in case only OFDM-NOMA, FBMC, or OFDM is applied.
‘Mad, bad, or possessed’? Perceptions of Self-Harm and Mental Illness in Evangelical Christian Communities
Authors: Lloyd Christopher E. M. , Panagopoulos Maxinne C. 
Published: March 2022

AbstractMental illness within evangelical Christian communities is frequently stigmatised, with many attributing it exclusively to demonic possession, lack of faith, personal sin, or other negative spiritual influences. This study explores perceptions of self-harm in the context of evangelical Christian faith communities using the novel qualitative story completion task. A convenience sample of 101 UK-based evangelical Christians completed a third-person fictional story stem featuring a devout female Christian who self-harms. A contextualist informed thematic analysis was carried out focusing on perceptions of cause, cure, and treatment. Most stories positioned spiritual causes of mental illness (that is, demonic possession or personal sin) as harmful to the individual by rendering individuals as stigmatised objects or as socially displaced. The stories also provided insight into negative perceptions of females experiencing mental illness within evangelical communities. The stories suggested that these views often led to stigma and shame, which ultimately exacerbated illness and led to reduced help-seeking. Conversely, stories depicting the integration of relational care alongside spiritual resources frequently led to recovery. That the stories represented the need for relational support, within a spiritually syntonic framework, for recovery from mental illness highlights the limitations of a dichotomised approach to pastoral care. Methodologically, the study demonstrates the usefulness of a seldom-used tool within the pastoral psychology context – the story completion task – for accessing sociocultural discourses and wider representations surrounding stigmatised topics or populations.
Revealing the underlying mechanisms mediated by endophytic actinobacteria to enhance the rhizobia - chickpea (Cicer arietinum L.) symbiosis
Authors: Xu Ting , Vo Q. A. Tuan , Barnett Steve J. , Ballard Ross A. , Zhu Yonghua , Franco Christopher M. M. 
Published: March 2022

Abstract
Purpose
The effects of endophytic actinobacterial strains, Microbispora sp. CP56, Actinomadura sp. CP84B, Streptomyces spp. CP200B and CP21A, on the chickpea-Mesorhizobium symbiosis, were investigated in planta, with the aim of revealing the underlying mechanisms of action.

Methods
The actinobacterial endophytes were co-inoculated with Mesorhizobium ciceri onto chickpea seedlings to study the effect on plant growth parameters, nodulation development and grain yield. The role of actinobacterial exudates on rhizobial growth was investigated, as was the role of root exudates of actinobacteria-colonized plants on the expression of rhizobial nod factors and biofilm formation. Changes in expression of plant flavonoids and bacterial N-fixation genes resulting from actinobacterial co-inoculation were assessed using qPCR.

Results
Application of actinobacterial endophytes, together with M. ciceri, showed growth promotion of chickpea with an increase in root nodule number and weight. Enhanced nodulation was accompanied by increases in total plant nitrogen, larger total plant weight and a 2–3-fold increase in grain yield. Factors associated with this tripartite symbiosis are promotion of rhizobial growth, earlier nodule formation, increased secondary root formation, up-regulated expression of genes related to flavonoid synthesis and nif genes. In addition, exudates of chickpea roots colonised with actinobacteria increased nodulation-related biological processes - rhizobial chemotaxis, biofilm formation and nod gene expression.

Conclusion
These endophytic actinobacteria positively affect many aspects of the chickpea-Mesorhizobium symbiosis resulting in increases in grain yield. Similar improvements recorded in chickpea growing in potted field soils, shows the potential to enhance chickpea production in the field.
Higher Taxes for Fiscal Consolidation? Expected and Unexpected Effects of Municipal Tax Policy
Authors: Hesse Mario 
Published: March 2022

AbstractDuring episodes of fiscal consolidation in public budgets, there are different instruments to choose from. The literature shows broad consensus that expenditure cuts are preferred, whereas tax increases tend not to support the fiscal aim. The paper examines instruments for fiscal consolidation at the municipal level in Germany presenting theoretical and empirical findings in favor of revenue-based instruments, focusing on the case of municipalities in the Free State of Saxony. German municipalities can autonomously control several positions on both the expenditure side and the revenue side. Options for expenditure cuts are given both for voluntary and compulsory tasks. On the revenue side, municipalities have the opportunity to set assessment rates on both local trade taxes and property taxes. For this part of the consolidation process, the prevailing opinion is that higher taxes are offset by lower grants, which is not the case in reality. Nevertheless, there are cannibalization effects to consider that may induce primary effects in the short and medium term. Hence, the paper shows an updated view of the drawbacks and opportunities of revenue-based fiscal consolidation. The paper provides evidence for an economic and political discussion that predominantly focuses strongly on the harmful effects of tax increases on the economy.
Controlling civic engagement of youth spanish muslims
Authors: Eseverri-Mayer Cecilia , Khir-Allah Ghufran 
Published: March 2022

AbstractThis paper focuses on Muslim Civil Society structures and, more specifically, on the gap between the organizations from the first (migrant) generation and the new grammars of action of new generations of Spanish Muslims. The originality of this article lies in its power to address three fundamental questions: (1) Are the umbrella organizations silencing the demands of Muslim youth?; (2) How do Muslim youth resist such representative hegemony? and; (3) What specific strategies are Muslim women currently developing to gain representation and involvement in mainstream Spanish society? We find evidence for new grammars of action defying traditional authorities and reject decontextualized, asynchronous Islam. Young women are engaging inbroaderandinclusiveactivism, inspired by religion affiliation in order to reinforce theirexternal solidarityand engagement in mainstream political structures. By contrast, young men are calling for a new Muslim leadership to reinforce primary solidarity and concentrate more on earning religious rights. For women, religion is avectorto participation and for men, it is aformof participation.
The Neuron Phenotype Ontology: A FAIR Approach to Proposing and Classifying Neuronal Types
Authors: Gillespie Thomas H. , Tripathy Shreejoy J. , Sy Mohameth François , Martone Maryann E. , Hill Sean L. 
Published: March 2022

AbstractThe challenge of defining and cataloging the building blocks of the brain requires a standardized approach to naming neurons and organizing knowledge about their properties. The US Brain Initiative Cell Census Network, Human Cell Atlas, Blue Brain Project, and others are generating vast amounts of data and characterizing large numbers of neurons throughout the nervous system. The neuroscientific literature contains many neuron names (e.g. parvalbumin-positive interneuron or layer 5 pyramidal cell) that are commonly used and generally accepted. However, it is often unclear how such common usage types relate to many evidence-based types that are proposed based on the results of new techniques. Further, comparing different types across labs remains a significant challenge. Here, we propose an interoperable knowledge representation, the Neuron Phenotype Ontology (NPO), that provides a standardized and automatable approach for naming cell types and normalizing their constituent phenotypes using identifiers from community ontologies as a common language. The NPO provides a framework for systematically organizing knowledge about cellular properties and enables interoperability with existing neuron naming schemes. We evaluate the NPO by populating a knowledge base with three independent cortical neuron classifications derived from published data sets that describe neurons according to molecular, morphological, electrophysiological, and synaptic properties. Competency queries to this knowledge base demonstrate that the NPO knowledge model enables interoperability between the three test cases and neuron names commonly used in the literature.
Nachhaltigkeit in der Altersvorsorge
Authors: Steinmeyer Heinz-Dietrich 
Published: March 2022

ZusammenfassungDer Begriff der Nachhaltigkeit wird inzwischen inflationär verwendet und dient zur Begründung zahlreicher Maßnahmen und Vorgehensweisen. Der Begriff wird auch in der Altersvorsorge zahlreich verwendet. Der Beitrag will der Frage nachgehen, welche Aussagekraft er im Allgemeinen und speziell für die Altersvorsorge hat. Es wird untersucht, ob und inwieweit sich der Begriff als Zielvorstellung eignet und welche konkreten Maßstäbe und Handlungsanleitungen sich aus ihm für die Altersvorsorge herleiten lassen. Es wird auch kritisch zur Verankerung des Nachhaltigkeitsgrundsatzes im primären EU-Recht und im Grundgesetz Stellung genommen. Insgesamt ergibt sich, dass die Diskussion zur Nachhaltigkeit zwar sinnvoll und wertvoll ist; sie kann aber ein abwägendes Nachdenken über die Fragen der Alterssicherung nicht ersetzen und liefert dafür auch nicht genügend konkreten Inhalt.
Computational Alloy Design for Process-Related Uncertainties in Powder Metallurgy
Authors: Molla T. T. , Atthapreyangkul A. , Schaffer G. B. 
Published: March 2022

AbstractAn integrated computational materials engineering approach to the design of alloys for supersolidus liquid phase sintering has been developed. The method aims to minimize the sensitivity of the alloys to variabilities in material (e.g., composition) and process parameters (e.g., temperature) during sintering while also maximizing mechanical properties. This is achieved by developing a fast acting and high throughput design models that can quantify the processability and the resulting mechanical properties. A highly processable alloy is defined as one that is tolerant to both composition and process conditions such that changes in either do not materially affect the alloy properties. The design models are validated using experimental data from the literature and the computational design approach is demonstrated by designing unique high-speed steels with enhanced processability for powder metallurgy.