bluuebunny/crossref_metadata_2025_split huggingface dataset:
Immune-mediated adverse events post-COVID vaccination and types of vaccines: a systematic review and meta-analysis
Authors: ElSawi Hind A. , Elborollosy Ahmed 
Published: May 2022

Abstract
Background
In late 2019, Coronavirus disease 2019 has been declared as a global emergency by World Health Organization. Hopefully, recent reports of effective and safe vaccines were welcomed, and approved on emergency base. Millions of recipients had received one of the approved COVID 19 vaccines, with lots of adverse events recorded global wide.

Objective
To assess post-COVID vaccination immune-mediated adverse events and evaluate its association to specific type of vaccine global wide.

Methods
Systematic literature review and meta-analysis of published reports (since December 2020 till December 2021) on immune-mediated adverse events post-COVID vaccination.

Results
We evaluated 34 published studies; 460 cases with various adverse events post-COVID vaccination. Studies in current literature are primarily retrospective case series, isolated case reports or narrative studies. Different COVID vaccines were involved. Results’ data was subcategorized according to associated vaccine. Adverse effects of COVID-19 vaccinations included thrombotic, neurological, myocarditis, ocular, dermatological, renal, hematological events timely linked to inoculation. Each vaccine type was linked to adverse profile that differ from others.

Conclusion
High suspicion of post-vaccination adverse events is mandatory to provoke earlier detection, better understanding, optimum prevention, and management. Specific vaccine/patient risk profile is needed to selectively categorize target population to reduce morbidity and mortality post-vaccination.
Vitamin D Levels During Pregnancy Are Associated With Offspring Telomere Length: A Longitudinal Mother-Child Study
Authors: Wong Kwun Kiu , Cheng Feifei , Mao Di , Lim Cadmon K P , Tam Claudia H T , Wang Chi Chiu , Yuen Lai Yuk , Chan Michael H M , Ho Chung Shun , Joglekar Mugdha V , Hardikar Anandwardhan A , Jenkins Alicia J , Metzger Boyd E , Lowe William L , Tam Wing Hung , Ma Ronald C W 
Published: May 2022

Abstract

Context
Leukocyte telomere length (LTL) is a biomarker of biological aging and is associated with metabolic diseases such as type 2 diabetes. Insufficient maternal vitamin D was associated with increased risk for many diseases and adverse later life outcomes.

Objective
This study investigates the relationship between vitamin D levels and offspring LTL at early life.

Methods
This observational, longitudinal, hospital-based cohort study included eligible mother-child pairs from the HAPO Hong Kong Field Centre, with 853 offspring at age 6.96 ± 0.44 (mean ± SD) years. LTL was measured using real-time polymerase chain reaction while serum vitamin D metabolites 25(OH)D2, 25(OH)D3, and 3-epi-25(OH)D3 were measured in maternal blood (at gestation 24-32 weeks) and cord blood by liquid chromatography–mass spectrometry.

Results
LTL at follow-up was significantly shorter in boys compared with girls (P &lt; 0.001) at age 7. Childhood LTL was negatively associated with childhood BMI (β ± SE = -0.016 ± 0.007)(P = 0.02) and HOMA-IR (β ± SE = −0.065 ± 0.021)(P = 0.002). Multiple linear regression was used to evaluate the relationship between 25(OH)D and LTL, with covariate adjustments. Childhood LTL was positively correlated with total maternal 25(OH)D (0.048 ± 0.017) (P = 0.004) and maternal 3-epi-25(OH)D3 (0.05 ± 0.017) (P = 0.003), even after adjustment for covariates. A similar association was also noted for cord 3-epi-25(OH)D3 (0.037 ± 0.018) (P = 0.035) after adjustment for offspring sex and age.

Conclusion
Our findings suggest 25(OH)D3 and 3-epi-25(OH)D3 in utero may impact on childhood LTLs, highlighting a potential link between maternal vitamin D and biological aging.
Reference Ranges for Bone Mineral Content and Density by Dual Energy X-Ray Absorptiometry for Young Children
Authors: Kalkwarf Heidi J , Shepherd John A , Fan Bo , Sahay Rashmi D , Ittenbach Richard F , Kelly Andrea , Yolton Kimberly , Zemel Babette S 
Published: May 2022

AbstractBackgroundAssessment of bone health in young children has been hampered by limited reference values for bone mineral content (BMC) and areal bone mineral density (aBMD) by dual energy X-ray absorptiometry (DXA).ObjectivesTo identify age, sex, and population ancestry effects on BMC and aBMD and develop smoothed reference ranges for BMC and aBMD in young children. To quantify precision of bone measurements and influence of height-for-age Z-scores on bone Z-scores.MethodsWe recruited 484 healthy children ages 1 to 2 years or 4.5 to 5 years at 2 clinical centers, who were seen once or up to 7 times over a 3-year period. Lumbar spine, distal forearm, and whole-body subtotal (ages ≥ 3 years) BMC and aBMD were measured by DXA. These data were combined with data from the Bone Mineral Density in Childhood Study from children ages 5 to 8.9 years to create the smoothed reference curves.ResultsFor 1- to 5-year-olds, BMC and aBMD at all skeletal sites increased with age. Age trends differed by sex for BMC and aBMD of the spine, distal one-third radius, ultradistal radius, and by ancestry (Black vs non-Black) for all measures. BMC and aBMD precision (% coefficient of variation) ranged from 1.0% to 4.4%. Height Z-scores were positively associated with bone Z-scores and accounted for 4% to 45% of the variance.ConclusionsWe demonstrate the feasibility of bone density measurements in young children and provide robust reference ranges and stature adjustments for calculation of bone Z-scores at multiple skeletal sites to enable bone health assessments.
Focal adhesion-mediated cell anchoring and migration: fromin vitrotoin vivo
Authors: Yamaguchi Naoya , Knaut Holger 
Published: May 2022

ABSTRACTCell-extracellular matrix interactions have been studied extensively using cells cultured in vitro. These studies indicate that focal adhesion (FA)-based cell-extracellular matrix interactions are essential for cell anchoring and cell migration. Whether FAs play a similarly important role in vivo is less clear. Here, we summarize the formation and function of FAs in cultured cells and review how FAs transmit and sense force in vitro. Using examples from animal studies, we also describe the role of FAs in cell anchoring during morphogenetic movements and cell migration in vivo. Finally, we conclude by discussing similarities and differences in how FAs function in vitro and in vivo.
High-dose vs low-dose steroid in pregnancy patients with systemic lupus erythematosus and lupus nephritis: A systematic review and meta-analysis
Authors: Thaha Mochammad , Alsagaff Mochamad Yusuf , Dwi Suryantoro Satriyo , Rizky Hayati Mutiara , Susilo Hendri , Nur Rosyid Alfian , Asmarawati Tri Pudy , Prabowo Emil , Syamsuri Ibrahim , Hakim Rais , Ilham Aldika Akbar Muhammad , Wibisono Nugroho Cahyo , Suzuki Yusuke 
Published: May 2022

Background: Management of systemic lupus erythematosus (SLE) and lupus nephritis (LN) in pregnancy has been improving in recent decades. However, SLE can still lead to adverse pregnancy outcomes if not appropriately treated. Optimal dose of steroids, as one of the most commonly used for the treatment of SLE and LN in pregnancy is still a subject of debate. In this review, we determine the pregnancy outcomes in SLE and LN patients treated with low vs high doses of steroids. Methods: ProQuest, Pubmed, Science Direct, Scopus, and Web of Science were carefully searched for relevant studies published in English. A total of 2,596 studies were reviewed. We extracted the data from previous studies showing the use of steroids treatment in high-dose and low-dose related to pregnancy outcomes. We provide larger data about maternal (preterm rupture of membrane, fetal loss, pre-eclampsia, and flare up) and fetal outcomes (prematurity, small gestational age, low birth weight) receiving high vs low steroid in patients with SLE and LN in this systematic review and meta-analysis. Results: A total of 13 studies were included. Of these, one study discussed a group with LN and 12 other studies discussed SLE with related maternal and fetal outcomes. Maternal outcome in the group with low-dose steroid showed a lower risk of fetal loss (odds ratio (OR): 1.93; 95% confidence interval (CI) 1.01-3.70), but there were no differences in other maternal outcomes. The low-dose steroid group showed a better fetal outcome, with a lower risk of prematurity (OR: 3.06; 95% CI 1.98-4.71), small gestational age (OR: 2.63; 95% CI 1.15-6.00), and low birth weight (OR: 2.43; 95% CI 1.23-4.79). Conclusions: In pregnant patients with SLE or LN, high-dose steroids are associated with the high risk of fetal loss during pregnancy, preterm birth, small gestational age, and low birth weight.
Relationships between changes in the state of neuroendocrine regulation and immunity in patients of Truskavets’ spa
Authors: Popovych Andriy , Popovych Igor , Popovych Dariya , Ruzhylo Sofiya , Żukow Xawery 
Published: May 2022

Background. Earlier we showed that the balneotherapeutic complex of Truskavets’ spa have significant modulating effects on parameters of EEG&HRV and Immunity of patients with chronic pyelonephritis and cholecystitis in remission accompanied of neuroendocrine-immune complex dysfunction. Were detected the close relationships between EEG, HRV, endocrine and immune parameters as well as between changes in EEG&HRV and immune parameters under the influence of balneotherapy. The aim of this study was to analyze the relationships between changes in the state of neuroendocrine regulation and immunity of the same patients. Materials and Methods. The object of clinical-physiological observation were 22 men aged 23-70 years, who underwent rehabilitation treatment of chronic pyelonephritis and cholecystitis in remission in the Truskavets’ spa. The examination was performed twice, before and after a 9-11-day course of balneotherapy. The subject of the study were the parameters of the electroencephalogram, heart rate variability, hormones and immunity. Results. The method of canonical correlation analysis states that the changes in immunity caused by balneotherapy are determined by the constellation of alaptation hormones by 98,9%, the autonomic nervous system by 99,9%, the central nervous system by 99,7%. Conclusion. Immunomodulatory effect of balneotherapy is realized through the neuro-endocrine mechanism.
Cancers preventive practice and the determinants in Amhara regional state, Northwest Ethiopia
Authors: Bantie Getasew Mulat , Tamirat Koku Sisay , Woya Ashenafi Abate , Melese Amare Alemu , Ayalew Agumas Fentahun , Wubetu Gizachew Asmare , Wassie Gizachew Tadesse , Mitiku Kalkidan Worku , Minale Minichil Genet , Dessie Amanuel Addisu , Kassa Selam Fisiha , Ayenew Girum Meseret 
Published: May 2022

Background
Cancer is the leading cause of morbidity and mortality globally. In Ethiopia, 5.8% of deaths are attributed to cancer. Therefore, this study aimed to examine the cancers preventive practice and associated factors in North West Ethiopia, 2019.

Methods
A community-based cross-sectional study was conducted among Bahir Dar city residents. A multistage sampling technique was used to select 845 study participants. Data were collected through a validated interviewer administered questionnaire. The questionnaire was adapted from the American cancer association cancer prevention toolkit. Descriptive statistics were computed and presented in charts and texts. The model fitness was checked using Hosmer and Lemeshow goodness of fit (P > 0.05). Bivariable and multivariable logistic regressions were used to identify factors associated with cancer preventive practice. A p-value < 0.2 at bivariate analysis was candidate variables for multivariable logistic regression analysis. Finally, p-value of < 0.05 was considered as a statistically significant predictor for cancer preventive practice at the 95% confidence interval.

Result
A total of 845 study participants took part in the study. Nearly 63% of the respondents were females. About 28% (95%CI: 24, 30) of the study participants had good preventive practice. Age ≥ 45 years (AOR = 0.31; 95%CI: 0.15, 0.62), female (AOR = 0.50, 95%CI: 0.35, 0.71) family member with cancer (AOR = 1.68, 95%CI: 1.07, 2.62) and had good knowledge (AOR = 1.66, 95%CI: 1.14, 2.42) were the identified determinants of cancer preventive practices.

Conclusion
This study revealed that the level of cancer preventive practices was low. Family member with cancer, knowledge about cancer, older age, and being female were significantly associated with cancer preventive practices. This finding underscores the importance of interventions to enhance cancer preventive practices.
Prevalence and characteristics of children with cerebral palsy according to socioeconomic status of areas of residence in a French department
Authors: Delobel-Ayoub Malika , Ehlinger Virginie , Klapouszczak Dana , Duffaut Carine , Arnaud Catherine , Sentenac Mariane 
Published: May 2022

Aim
To study the association between the socioeconomic environment of area of residence and prevalence and characteristics of children with cerebral palsy (CP).

Method
Data on 8-year-old children with CP born in 2000–2011 (n = 252) were extracted from a regional population-based register in France. The European Deprivation Index (EDI), available at census block level, characterised socioeconomic deprivation in the child’s area of residence at age of registration. The prevalence of CP was estimated in each group of census units defined by EDI distribution tertiles in the general population. The association between deprivation level and CP severity was assessed according to term/preterm status.

Results
CP prevalence differed between deprivation risk groups showing a J-shaped form with the prevalence in the most deprived tertile (T3) being the highest but not significantly different of the prevalence in the least deprived one (T1). However, the prevalence in the medium deprivation tertile (T2) was significantly lower than that in the most deprived one with a prevalence risk ratio (PRR) of: PRRT2/T3 = 0.63 95% CI [0.44–0.89]). Prevalences of CP with associated intellectual disability (ID) and CP with inability to walk were significantly higher in the most deprived tertile compared to the least deprived one (respectively PRRT3/T1 = 1.86 95% CI [1.19–2.92] and PRRT3/T1 = 1.90 95% CI [1.07–3.37]). Compared to children living in the least deprived areas, children with CP born preterm living in the most deprived areas had more severe forms of motor impairment, such as an inability to walk or a combination of an inability to walk and moderate to severe impairment of bimanual function. They also had more associated intellectual disability. No associations were observed among term-born children.

Interpretation
A significant association between area deprivation group and CP severity was observed among preterm children but not among term-born children.
The importance of physical performance in the assessment of patients on haemodialysis: A survival analysis
Authors: Vanden Wyngaert Karsten , Van Biesen Wim , Eloot Sunny , Van Craenenbroeck Amaryllis H. , Calders Patrick , Holvoet Els 
Published: May 2022

Background
Physical performance is an important determinant of quality of life in patients on haemodialysis. An association between physical performance and survival could further enhance the importance of physical performance. We aimed to assess the association between different measures of physical performance and survival in dialysis patients.

Methods
117 patients on haemodialysis were included from December 2016 and followed up to September 2020. Muscle strength (quadriceps, handgrip strength, and sit-to-stand), exercise capacity (six-minute walking test, 6MWT) and the risk of falls (Dialysis Fall Index, Tinetti, and Frailty and Injuries: Cooperative Studies of Intervention Techniques) were measured at the time of inclusion. Hospitalisation, morbidity (Davies Stoke index) and death were recorded. Data were analysed by least squares linear regression models and competing risks survival hazard models.

Results
During the observation period (median 33, min 30 max 45 months), 45 patients died (= 38.5%), resulting in a mortality rate of 15% per year. Cardiovascular disease (42.9%) was the most common cause of death. All domains of physical performance were associated with mortality, with the highest hazards for an increased risk of falls (Hazard Ratio (HR) = 20.4, p = 0.003) and poor exercise capacity (HR = 7.4, p<0.001). A score lower than 298 meters (specificity = 0.583; sensitivity = 0.889) on the 6MWT was established as a haemodialysis-specific cut-off point for mortality risk. Each increase in 6MWT (m) corresponded with a 0.4% decrease in mortality risk (HR = 0.996, 95%CI [0.994; 0.998]). The 6MWT as also associated with comorbidity (F-value = 6.1, p = 0.015). Physical performance was not associated with hospitalisation.

Conclusions
The 6MWT is associated with mortality in patients on haemodialysis and can be considered as a valid assessment tool to identify high-risk patients.
Augmented muscle deoxygenation during repeated sprint exercise with post‐exercise blood flow restriction
Authors: Ienaga Koki , Yamaguchi Keiichi , Ota Naoki , Goto Kazushige 
Published: May 2022

AbstractBlood flow restriction (BFR) during low‐intensity exercise has been known to be a potent procedure to alter metabolic and oxygen environments in working muscles. Moreover, the use of BFR during inter‐set rest periods of repeated sprint exercise has been recently suggested to be a potent procedure for improving training adaptations. The present study was designed to determine the effect of repeated sprint exercise with post‐exercise BFR (BFR during rest periods between sprints) on muscle oxygenation in working muscles. Eleven healthy males performed two different conditions on different days: either repeated sprint exercise with BFR during rest periods between sets (BFR condition) or without BFR (CON condition). A repeated sprint exercise consisted of three sets of 3 × 6‐s maximal sprints (pedaling) with 24s rest periods between sprints and 5 min rest periods between sets. In BFR condition, two min of BFR (100–120 mmHg) for both legs was conducted between sets. During the exercise, power output and arterial oxygen saturation (SpO2) were evaluated. Muscle oxygenation for the vastus lateralis muscle, exercise‐induced changes in muscle blood flow, and muscle oxygen consumption were measured. During BFR between sets, BFR condition presented significantly higher deoxygenated hemoglobin + myoglobin (p < 0.01) and lower tissue saturation index (p < 0.01) than those in CON condition. However, exercise‐induced blood lactate elevation and reduction of blood pH did not differ significantly between the conditions. Furthermore, power output throughout nine sprints did not differ significantly between the two conditions. In conclusion, repeated sprint exercise with post‐exercise BFR augmented muscle deoxygenation and local hypoxia, without interfering power output.
Biomechanical comparison of different prosthetic materials and posterior implant angles in all-on-4 treatment concept by three-dimensional finite element analysis
Authors: Gürbüz Ayhan , Güçlü Zekiye Begüm , Deste Gökay Gonca , Durkan Rukiye 
Published: May 2022

Abstract
The study aimed to evaluate the biomechanical behaviors of different prosthetic materials and posterior implant angles in All-on-4 implant-supported fixed maxillary prostheses with three-dimensional (3D) finite element analysis. The model of complete edentulous maxilla was created using the Rhinoceros and VRMesh Studio programs. Anterior vertical and 17°- and 30°-angled posterior implants were positioned with All-on-4 design. Straigth and angled multi-unit abutments scanned using a 3D scanner. Two different prosthetic superstructures (monolithic zirconia framework and lithium disilicate veneer (ZL) and monolithic zirconia-reinforced lithium silicate (ZLS)) were modeled. Four models designed according to the prosthetic structure and posterior implant angles. Posterior vertical bilateral loading and frontal oblique loading was performed. The principal stresses (bone tissues-Pmax and Pmin) and von Mises equivalent stresses (implant and prosthetic structures) were analyzed. In all models, the highest Pmax stress values were calculated under posterior bilateral loading in cortical bone. The highest von Mises stress levels occured in the posterior implants under posterior bilateral load (260.33 and 219.50 MPa) in the ZL-17 and ZL-30 models, respectively. Under both loads, higher stress levels in prosthetic structures were shown in the ZLS models compared with ZL models. There was no difference between posterior implant angles on stress distribution occurred in implant material and alveolar bone tissue. ZLS and ZL prosthetic structures can be reliably used in maxillary All-on-4 rehabilitation.
Decision support system to evaluate a vandalized and deteriorated oil pipeline transportation system using artificial intelligence techniques. Part 1: modeling
Authors: Cid-Galiot Jonathan J. , Aguilar-Lasserre Alberto A. , Grande-Ramírez José R. , Meza-Palacios Ramiro , Rodríguez-Jarquín José Pastor 
Published: May 2022

Abstract
The oil and gas industry worldwide is experiencing problems of vandalism and mechanical deterioration due to corrosion in its various pipeline transport systems, a drop in the price of hydrocarbons due to the COVID-19, limitation of maintenance processes. This article provides a contribution original to the knowledge and management of a pipeline transportation system (PTS), without an immediate high impact that would help reduce property loss due to corrosion, through the development of intelligent evaluation models that combine field data, laboratory, and cognitive knowledge in a case study in Mexico. The research is divided into Part 1: modeling, a Fuzzy expert system (FES) unified the knowledge of corrosion specialists and mechanical integrity studies (MIS) and identified evolutionary corrosion patterns with reliability of 0.9029. An artificial neural network (ANN) supported by statistics and metallography establishes test reliability of 0.9556 and determines the corrosion inhibition capacity (C) of Mexican hydrocarbon mixtures based on their properties compared to carbon steel. Part 2: analysis of the operational and economic risk of the PTS under corrosive effects, using Monte Carlo simulation (MCS) estimates various financial scenarios considering corrosive profiles of soils, supply, demand, and inflation.
Notes on the life history ofCenturio senex(Chiroptera: Phyllostomidae) from northern Central America
Authors: Trujillo Luis A. , Martínez-Fonseca José G. , Hernández Jonathan , Cajas-Castillo José O. , Girón-Galván Luis , Medina-Fitoria Arnulfo , Rodríguez Melissa E. , Barahona-Fong Raiza 
Published: May 2022

AbstractThe wrinkled-faced bat (Centurio senex) is an enigmatic species widely distributed in Mesoamerica. Besides its wide distribution it is considered rare in almost the entire range and little is known about its life history. We provide notes and discuss on the natural history of the species and performed a distribution model and an elevation profile in order to understand the distribution patterns in Northern Central America. We found thatC. senexinhabits ecosystems from lowlands to 1943 m, with higher probability of occurrence in the Pacific region and the mountains of Guatemala in which seasonal precipitation regimes predominates.