bluuebunny/crossref_metadata_2025_split huggingface dataset:
A transformer model for predicting cognitive impairment from sleep
Authors: Song Tzu-An , Malekzadeh Masoud , Saxena Richa , Purcell Shaun M. , Dutta Joyita 
Published: July 2022

AbstractSleep disturbances are known to be aggravated with normal aging. Additionally, sleep disruptions have a potentially bidirectional causal relationship with dementia due to neurodegenerative diseases like Alzheimer’s disease. Predictive techniques that can automatically detect cognitive impairment from an individual’s sleep data have broad clinical and biological significance. Here, we present a deep learning approach based on a transformer architecture to predict cognitive status from sleep electroencephalography (EEG) data. This work uses data fromN= 1, 502 subjects from the Multi-Ethnic Study of Atherosclerosis (MESA) cohort. Our transformer model achieves 70.22% accuracy at the binary classification task for distinguishing cognitively normal and impaired subjects based on their sleep EEG. Our method outperforms traditional feature handcrafting, which has an overall accuracy of 57.61% for the same task. We use a sparse regression model to understand and interpret the information captured by each learned feature from our transformer model. To our knowledge, this is the first effort to use deep learning to predict cognitive impairment from sleep metrics.
Proximal dendritic localization of NALCN channels underlies tonic and burst firing in nigral dopaminergic neurons
Authors: Hahn Suyun , Um Ki Bum , Kim Hyun Jin , Park Myoung Kyu 
Published: July 2022

AbstractIn multipolar nigral dopamine (DA) neurons, the highly excitable proximal dendritic compartments (PDCs) and two Na+-permeable leak channels, TRPC3 and NALCN, play a key role in pacemaking. However, the causal link between them is unknown. Here we report that the proximal dendritic localization of NALCN underlies pacemaking and burst firing in DA neurons.Our morphological analysis of nigral DA neurons reveals that TRPC3 is ubiquitously expressed in the whole somatodendritic compartment, but NALCN is localized within the PDCs. Blocking either TRPC3 or NALCN channels abolished pacemaking. However, only blocking NALCN, not TRPC3, degraded burst discharges. Furthermore, local glutamate uncaging readily induced burst discharges within the PDCs, compared with other parts of the neuron, and NALCN channel inhibition dissipated burst generation, indicating the importance of NALCN to the high excitability of PDCs. Therefore, we conclude that PDCs serve as a common base for tonic and burst firing in nigral DA neurons.
Structural basis for antibody-mediated neutralization of Lymphocytic choriomeningitis virus
Authors: Moon-Walker Alex , Zhang Zeli , Zyla Dawid S. , Buck Tierra K. , Li Haoyang , Avalos Ruben Diaz , Schendel Sharon L. , Hastie Kathryn M. , Crotty Shane , Saphire Erica Ollmann 
Published: July 2022

SummaryThe mammarenavirus Lymphocytic choriomeningitis virus (LCMV) is a globally distributed zoonotic pathogen that can be lethal in immunocompromised patients and cause severe birth defects if acquired during pregnancy. Despite the fundamental importance of LCMV for studying immunobiology, the structure of the trimeric surface glycoprotein, essential for entry, vaccine design and antibody neutralization, remains unknown. In this study, we present the cryoEM structure of the LCMV surface glycoprotein (GP) in its trimeric prefusion assembly both alone and in complex with a rationally engineered monoclonal neutralizing antibody termed 18.5C-M28 (M28). Additionally, we show that passive administration of M28 protects mice from LCMV clone 13 (LCMVcl13) challenge when administered as either a prophylactic or therapeutic. Our study illuminates not only the overall structural organization of LCMV GP and the mechanism for its inhibition by M28, but also presents a promising therapeutic candidate to prevent severe or fatal disease in individuals who are at risk of infection by a virus that poses a threat worldwide.HighlightsRationally-engineered antibody M28 neutralizes lymphocytic choriomeningitis virus in vitro.First high-resolution cryoEM structure of the pre-fusion trimeric lymphocytic choriomeningitis virus glycoprotein alone and in complex with M28.M28 neutralizes by bridging adjacent glycoprotein protomers and locking it in the pre-fusion state.Prophylactic and therapeutic administration of M28 protects mice from chronic lymphocytic choriomeningitis virus infection.
Acoustic Correlates of the Syllabic Rhythm of Speech: Modulation Spectrum or Local Features of the Temporal Envelope
Authors: Zhang Yuran , Zou Jiajie , Ding Nai 
Published: July 2022

AbstractThe speech envelope is considered as a major acoustic correlate of the syllable rhythm since the peak frequency in the speech modulation spectrum matches the mean syllable rate. Nevertheless, it has not been quantified whether the peak modulation frequency can track the syllable rate of individual utterances and how much variance of the speech envelope can be explained by the syllable rhythm. Here, we address these problems by analyzing large speech corpora (>1000 hours of recording of multiple languages) using advanced sequence-to-sequence modeling. It is found that, only when averaged over minutes of speech recordings, the peak modulation frequency of speech reliably correlates with the syllable rate of a speaker. In contrast, the phase-locking between speech envelope and syllable onsets is robustly observed within a few seconds of recordings. Based on speaker-independent linear and nonlinear models, the timing of syllable onsets explains about 13% and 46% variance of the speech envelope, respectively. These results demonstrate that local temporal features in the speech envelope precisely encodes the syllable onsets but the modulation spectrum is not always dominated by the syllable rhythm.
Rethinking peer-to-peer communication: how different mediums and product types influence consumers’ language
Authors: Forouhandeh Behnam , Clarke Rodney J. , Reynolds Nina Louise 
Published: July 2022

PurposeThe purpose of this paper is to demonstrate the utility of systemic functional linguistics (SFL) as an underlying model to examine the similarities/differences between spoken and written peer-to-peer (P2P) communication.Design/methodology/approachAn embedded mixed methods experimental design with linguistically standardized experimental stimuli was used to expose the basic linguistic differences between P2P communications that can be attributed to communication medium (spoken/written) and product type (hedonic/utilitarian).FindingsThe findings show, empirically, that consumer’s spoken language is not linguistically equivalent to that of written language. This confirms that the capability of language to convey semantic meaning in spoken communication differs from written communication. This study extends the characteristics that differentiate hedonic from utilitarian products to include lexical density (i.e. hedonic) vs lexical sparsity (i.e. utilitarian).Research limitations/implicationsThe findings of this study are not wholly relevant to other forms of consumer communication (e.g. viral marketing). This research used a few SFL resources.Practical implicationsThis research shows that marketers should ideally apply a semantic approach to the analysis of communications, given that communication meaning can vary across channels. Marketers may also want to focus on specific feedback channels (e.g. review site vs telephone) depending on the depth of product’s details that need to be captured. This study also offers metrics that advertisers could use to classify media and to characterize consumer segments.Originality/valueThis research shows the relevance of SFL for understanding P2P communications and has potential applications to other marketing communications.
Developing a framework for building maintenance: a case study of Malaysia's low-cost housing via soft system methodology
Authors: Ebekozien Andrew , Samsurijan Mohamad Shaharudin , Aigbavboa Clinton , Awo-Osagie Andrew I. 
Published: July 2022

PurposeThe cost of residential building maintenance can harmfully affect low-income earners' expenditure if not checked. A customised maintenance concept via a framework will ensure efficient and proper building maintenance operations. The outcome may keep the life cycle cost down. Studies concerning the low-cost housing (LCH) maintenance concept through a framework are scarce in Malaysia. Thus, the study aims to investigate the state of LCH and develop a framework to improve LCH maintenance practices in Malaysia.Design/methodology/approachThe study adopted a soft system methodology (SSM) to comprehend Malaysia's LCH building maintenance practices. The SSM allowed an alternative approach to improve LCH maintenance practices via a developed framework. Virtual interviews were conducted with experts, and findings were presented. It was in line with the SSM seven steps.FindingsThe findings show that apart from the poor state of LCH maintenance, there is the absence of a framework to improve maintenance practices, especially in LCH across Malaysia's cities. The findings developed a framework that would reposition the joint management body and management corporation in collaboration with the proposed maintenance agency for better service delivery via substantive, technical and administrative aspects.Research limitations/implicationsThis study's data collection is restricted to Pulau Pinang, Kuala Lumpur and Johor through a qualitative research design approach. Future research is needed to consider more extensive coverage and validate the developed framework from this study via a quantitative research design.Practical implicationsApart from the conceptual model that was developed, the suggested framework can be employed by Malaysia's maintenance practitioners and policymakers as a guideline to improve LCH building maintenance practices across the cities.Originality/valueThis study examined Malaysia's LCH maintenance practices via SSM to identify the state of the houses, identify the information required and propose a suitable framework to improve Malaysia's LCH maintenance practices.
Resource-controlled stochastic customer order scheduling via particle swarm optimization with bound information
Authors: Zhao Yaping , Kong Xiangtianrui , Xu Xiaoyun , Xu Endong 
Published: July 2022

PurposeCycle time reduction is important for order fulling process but often subject to resource constraints. This study considers an unrelated parallel machine environment where orders with random demands arrive dynamically. Processing speeds are controlled by resource allocation and subject to diminishing marginal returns. The objective is to minimize long-run expected order cycle time via order schedule and resource allocation decisions.Design/methodology/approachA stochastic optimization algorithm named CAP is proposed based on particle swarm optimization framework. It takes advantage of derived bound information to improve local search efficiency. Parameter impacts including demand variance, product type number, machine speed and resource coefficient are also analyzed through theoretic studies. The algorithm is evaluated and benchmarked with four well-known algorithms via extensive numerical experiments.FindingsFirst, cycle time can be significantly improved when demand randomness is reduced via better forecasting. Second, achieving processing balance should be of top priority when considering resource allocation. Third, given marginal returns on resource consumption, it is advisable to allocate more resources to resource-sensitive machines.Originality/valueA novel PSO-based optimization algorithm is proposed to jointly optimize order schedule and resource allocation decisions in a dynamic environment with random demands and stochastic arrivals. A general quadratic resource consumption function is adopted to better capture diminishing marginal returns.
Innovating beyond firm boundaries: resource deployment control in open source software development
Authors: Schaarschmidt Mario 
Published: July 2022

PurposeIn times of open and distributed innovation, many innovation activities that are important for firms' products and services take place beyond the boundaries of the firm and thus beyond firms' direct control. A prime example for this phenomenon is open source software (OSS) development, where multiple actors contribute to a public good, which is also integrated into company-owned software products. Despite the importance of aligning community work on the public good with own in-house development efforts, firms have limited options to directly control the OSS project or the project's outcome. This research reflects on resource deployment control, a control mode in which firms assign own developers to work for an OSS project to influence the OSS project, and tests hypotheses on individual developer levels.Design/methodology/approachThis research tests the effect of perceived resource deployment control on opinion leadership by analyzing employed Linux kernel developers.FindingsThe findings show that developers who perceive being assigned to an OSS project to enact control also exhibit opinion leadership. This research also investigates boundary conditions such as the OSS business model a firm operates and the reputation developers assign to the developers' employer.Originality/valueThis research is the first that is devoted to resource deployment control, and the research closes with a discussion of implications for control theory and the management of innovation beyond firm boundaries.
The impact of the coronavirus pandemic on the market for childcare
Authors: Thomas Diana Weinert 
Published: July 2022

PurposeThis paper assesses the short-term consequences of the COVID-19 pandemic on the market for childcare and speculates about potential long-term consequences of pandemic-related policy intervention.Design/methodology/approachThe paper uses basic statistics and data to describe changes in the market for childcare.FindingsPolicy responses to the pandemic likely aggravated pre-existing trends in the market for childcare, drove up the cost of production at a time when demand was collapsed because of the pandemic, and ultimately resulted in systematic closures of childcare centers. These closures will be difficult to reverse due to the high cost of entry into the industry and overall low profitability.Research limitations/implicationsThe study is just a preliminary investigation in its current form that points to future areas of research.Originality/valueThis paper summarizes the results of existing studies and draws some basic conclusions about the effects of policy intervention.
Fast fashion: business models and strategies for adapting to the COVID-19 crisis
Authors: Li Ling 
Published: July 2022

PurposeThis study aims to develop and test a methodical approach to assessing the effectiveness of business models in fast fashion.Design/methodology/approachThe approach allows one to identify the key features of companies' adaptation strategies during the COVID-19 pandemic. The paper analyzes the economic profitability of the fast-fashion industry and establishes business opportunity trends. The author identifies a set of general characteristics of business related to supply and demand before and during the pandemic crisis. The study relies on descriptive statistics and statistical processing methods, including regression analysis, arithmetic mean and the indicator of market economy dynamics.FindingsThe study found that the fast-fashion business model allows companies to adapt to the new market norms because of its dual strategy: demand-driven transparency and supply-driven sustainability, within the logic of consumption. The results indicate that focus on sustainability and transparent stakeholder engagement helps companies to remain relevant in the fashion industry.Originality/valueThe results of the study can be used by general managers of companies, marketers and administrative managers to select strategies and make decisions under the current and future fashion industry demands in markets at different developmental stages.
Audit fees, audit seasonality and audit quality in Nigeria: a mediation analysis
Authors: Ayoola Tajudeen John 
Published: July 2022

Purpose
This study aims to examine the mediating role of audit seasonality on the association between audit fees and audit quality in Nigerian deposit money banks.

Design/methodology/approach
The sample comprises 14 banks with annual financial statements between 2008 and 2020. The modified Baron and Kenny’s (1986) causal mediation model by Iacobucci et al. (2007) through the use of bootstrapped partial least square structural equation modelling and Sobel’s (1986) z-test is adopted to achieve this study’s objective.

Findings
The results of the causal mediation analysis show evidence of a fully mediating role of c between audit fees and audit quality in the Nigerian banking industry.

Research limitations/implications
This study extends the body of knowledge by demonstrating how audit fees influence audit quality through audit seasonality as a mediator in line with the job demands-and resources and conservation of resources theories. Regulatory authorities should be wary of policies that will further increase the workload of already burdened personnel of audit firms as the uniform fiscal year-end of 31 December introduced in the Nigerian banking system has unintended consequences on audit fees and audit quality.

Originality/value
To the best of the author’s knowledge, this is one of the first studies to provide evidence on the indirect association between audit fees and audit quality.
Covid 19 vaccine order allocation: an optimization model with substitution
Authors: Sarigol Ilkan , Ozdemir Rifat Gurcan , Bayraktar Erkan 
Published: July 2022

PurposeThis paper focuses on multi-objective order allocation with product substitution for the vaccine supply chain under uncertainty.Design/methodology/approachThe weighted-sum minimization approach is used to find a compromised solution between three objectives of minimizing inefficiently vaccinated people, postponed vaccinations, and purchasing costs. A mixed-integer formulation with substitution quantities is proposed, subject to capacity and demand constraints. The substitution ratios between vaccines are assumed to be exogenous. Besides, uncertainty in supplier reliability is formulated using optimistic, most likely, and pessimistic scenarios in the proposed optimization model.FindingsCovid-19 vaccine supply chain process is studied for one government and three vaccine suppliers as an illustrative example. The results provide essential insights for the governments to have proper vaccine allocation and support governments to manage the Covid-19 pandemic.Originality/valueThis paper considers the minimization of postponement in vaccination plans and inefficient vaccination and purchasing costs for order allocation among different vaccine types. To the best of the authors’ knowledge, there is no study in the literature on order allocation of vaccine types with substitution. The analytical hierarchy process structure of the Covid-19 pandemic also contributes to the literature.
Revisiting the terrorism–tourism nexus in Nigeria: the moderating role of military spending
Authors: Raifu Isiaka Akande , Afolabi Joshua Adeyemi , Oguntimehin Jr Olusegun Joseph 
Published: July 2022

PurposeTourism development is critical for economic transformation, particularly in emerging economies. However, the growing spate of terrorism dissuades international tourists, reduces tourism receipts and ultimately hampers the tourism sector's performance. Thus, the government intervenes by altering its military spending to curtail terrorism. Against this backdrop, this study examines the moderating role of military spending in the terrorism–tourism nexus in Nigeria.Design/methodology/approachThe study employs the dynamic ordinary least squares (DOLS) to investigate the moderating role of military spending in the terrorism–tourism nexus in Nigeria. The authors employ the data that cover the period 1995Q1–2019Q4.FindingsThe results reveal that terrorism has a catastrophic effect on tourism arrivals in Nigeria while military spending has a positive impact on tourism arrivals. The results further show the moderating role of military spending in the terrorism–tourism nexus is positive and statistically significant. However, the findings are subject to the measures of military spending, terrorism and tourism.Practical implicationsThe practical implication of the findings is the need for deliberate and strategic budgeting for the Ministry of Defence to combat terrorism, which should not only focus on the procurement of arms and ammunition but also cover the welfare of the military personnel. Nigeria also needs to formulate and implement necessary tourism policies aimed at countering terrorism in a bid to create and maintain a positive image on the global tourist map.Originality/valueMany studies, particularly in developing countries like Nigeria, had examined the effect of terrorism on tourism but none has examined the moderating role of military spending in the terrorism–tourism nexus. Hence, this study examines the moderating role of military spending in the relationship between terrorism and tourism in Nigeria, a terrorism-prone country with several tourist sites.
What literature has to say about commitment to change: philosophy of commitment to change
Authors: Kayani Muhammad Bilal , Ali Maryam , Javed Hassan 
Published: July 2022

PurposeThis paper aims to conclude and provide a review of the current literature on a commitment to change (C2C). Detailed research is provided on the operationalization and conceptualization of C2C.Design/methodology/approachThe review is conducted based on 55 research papers published in different journals at different times in the past on C2C.FindingsA complete framework from previous to latest literature has been depicted in the current paper on a C2C with their citation in the one study. Gaps that had not been addressed by previous authors are also highlighted to facilitate future researchers in regards to C2C. Especially in the context of quantitative studies gaps are highlighted in previous literature of C2C.Practical implicationsFuture researchers can study the highlighted gaps with regards to C2C. Further it provides researchers a brief summary of 55 researches on C2C.