bluuebunny/crossref_metadata_2025_split huggingface dataset:
Study on the high‐temperature damping properties of silicone rubber modified by boron‐terminated polysiloxane
Authors: Cui Hongwei , Jing Qian , Li Dongwei , Zhuang Tingting , Gao Yixing , Ran Xianghai 
Published: October 2022

AbstractRubber damping materials have important applications in modern industrial systems. However, their damping temperature range is low, which is not suitable for the damping demand under high temperature conditions. At present, there is very little research on the damping performance of rubber under high temperature conditions. Silicone rubber has excellent high temperature resistance but poor damping in its application temperature range. In this study, a boron‐terminated polysiloxane (PBS) was prepared by modifying hydroxy‐terminated polydimethylsiloxane (PDMS‐OH) with boric acid (BA). The molecular structure of PBS was confirmed by Fourier transform infrared spectroscopy (FTIR), nuclear magnetic resonance (NMR) and gel permeation chromatography (GPC) analysis. Rheology measurements revealed that PBS was a “shear hardening” material. Then, the silicone rubber was modified with PBS. With the introduction of boron atoms, boron and oxygen dative bonds with dynamic properties could be formed inside the silicone rubber, which played an energy dissipation role in the process of association/dissociation. Dynamic mechanical analysis (DMA) showed that the loss factor (tan δ) of modified silicone rubber was greater than 0.3 in the temperature range of 81.5°C–250°C, which was higher than the loss temperature range of conventional damping rubber. The cyclic stress–strain test also showed that the modified silicone rubber still had high dissipation coefficient (DE) at high temperature. Therefore, the PBS‐modified silicone rubber prepared by this method achieved excellent damping performance under high temperature conditions.
Development and validation of an LC–MS/MS method for detection of glycyrol in rat plasma and its application to a pharmacokinetic study
Authors: Cheng Lei , Deng Yan , An Liqun , Zhang Yan , Liu Hong , Wu Xinyu , Wang Tingting , Yang Xixiao , Ye Linhu 
Published: October 2022

AbstractLicorice (Glycyrrhiza uralensis) is one of the most popular edible and medicinal plants and is widely used in Asia. Glycyrol (GC) is a major coumarin present in licorice that exhibits various biological activities. We aimed to develop a highly sensitive and rapid liquid chromatography coupled with mass spectrometry method for the quantitative determination analysis of GC in rat plasma. GC showed linear calibration ranges of 1–100 and 50–2,000 ng/ml with correlation coefficients >0.99. The average extraction recovery ranged from 113.26 to 114.84%, and the relative standard deviation of internal standard normalized matrix factors ranged from 6.36 to 9.46%. The intra‐day and inter‐day precisions of GC were <15%, and the accuracy ranged from 95.31 to 112.72%. Pharmacokinetic studies showed that GC was distributed in the body with a volume of distribution of 9.06 L/kg, and the initial plasma concentration was 3275.11 ng/ml. The area under the plasma concentration vs. time curve was 479.25 ng h/ml. It was rapidly eliminated with a terminal elimination half‐life of 1.47 h and a clearance rate of 4.24 L/h/kg. The pharmacokinetic results can help us to better understand the pharmacological effects of GC in the body.
Theranostic mesoporous platinum nanoplatform delivers halofuginone to remodel extracellular matrix of breast cancer without systematic toxicity
Authors: Zhang Jie , Xu Ziqing , Li Yang , Hu Yongzhi , Tang Jiajia , Xu Jiaqi , Luo Yafei , Wu Feiyun , Sun Xiaolian , Tang Yuxia , Wang Shouju 
Published: October 2022

AbstractThe enriched collagens in the extracellular matrix (ECM) of breast cancer substantially impede drug delivery. Halofuginone (HF), a potent antifibrotic agent, was effective to deplete the collagens and remodel the ECM by inhibiting the TGFβ pathway. However, the application of HF was hindered by its strong liver toxicity. Herein, mesoporous platinum (mPt) nanoparticles were constructed to load HF as theranostic nanoplatforms. mPt had a uniform spherical structure with a diameter of 79.83 ± 6.97 nm and an average pore diameter of 20 nm and exhibited good photothermal conversion efficiency of 62.4%. The obtained HF‐loaded nanoplatform (PEG@mPt‐HF) showed enhanced cytotoxicity through the combination of photothermal therapy and the anti‐TGFβ effect induced by HF. The animal imaging and histochemical assays confirmed the PEG@mPt‐HF could efficiently deliver HF to tumors (monitored by CT) and remodel the ECM by TGFβ pathway inhibition, which resulted in increased anti‐cancer efficacy. Importantly, the liver toxicity observed in HF‐treated mice was negligible in those treated by PEG@mPt‐HF. Overall, this study designed a theranostic nanoplatform to remodel the ECM with remarkably reduced systematic toxicity and enhance the therapeutic efficacy through combination treatment.
Brothers and sisters of childhood acute leukemia survivors: Their long‐term quality of life and its determinants
Authors: Faust Cindy , Auquier Pascal , Hamidou Zeinab , Bertrand Yves , Tabone Marie‐Dominique , Ansoborlo Sophie , Baruchel André , Gandemer Virginie , Dalle Jean‐Hugues , Chastagner Pascal , Kanold Justyna , Poirée Maryline , Sirvent Nicolas , Plat Geneviève , Pellier Isabelle , Michel Gérard , Berbis Julie 
Published: October 2022

AbstractBackgroundChildhood cancer confront the whole family with a traumatic event. Because brothers and sisters may encounter emotional problems that can remain for a long time and that only few studies have assessed their long‐term outcome, our present objectives were to describe the long‐term quality of life (QoL) of childhood leukemia survivors' siblings and to explore its determinant.MethodsBrothers and sisters (from 8‐year‐old) of survivors included in the French LEA Cohort completed a QoL questionnaire (according to their age). Scores were compared with those reported by age‐ and gender‐matched French general population and by survivors. Using a clustering method, siblings were categorized into 3 groups depending on their level of QoL's scores and factors likely to be linked with these clusters were explored with multivariate analyses.ResultsWe included 689 brothers and sisters (313 minors, 376 adults) and the mean time from diagnosis was 13.2 ± 6.6 years. Minor siblings reported higher QoL scores than general population (p < 0.001), but a lower score for relationship with family than survivors (p < 0.001). In adult siblings, Mental Component Summary score was lower than general population (p < 0.001). Level of siblings' QoL was linked with female gender, but no association was found with cancer‐related factors.ConclusionBrothers and sisters expressed a divergent perception of their long‐term QoL depending on their age. To minimize the impact from childhood to adulthood, long‐term attention should also be paid to siblings, often referred as “forgotten children”.
Cotrimoxazole‐induced hyperkalemia in renal transplant patient—Case report
Authors: Srikaram Prakhyath , Siddiqui Amna , Gul Fahad , Deuja Puja , Fatima Nabeela 
Published: October 2022

AbstractWe present the case of a 55‐year‐old male patient who developed hyperkalemia after using Cotrimoxazole (TMP‐SMX). There was a marked increase in potassium levels from 3.3 mEq/L on Day 5 when cotrimoxazole was started to 6.2 mEq/L on Day 11 when the drug was withheld.
Efficient Base‐Catalyzed Hydrosilylation of Tertiary Amides to Aldehydes
Authors: Clarke Joshua A. , Nikonov Georgii I. 
Published: October 2022

AbstractA chemoselective catalytic reduction of tertiary amides to aldehydes is reported. The catalytic system KOtBu/(EtO)2MeSiH has been found to be highly active in the conversion of tertiary amides to silylated hemiaminals, which after acidic work‐up yields the respective aldehydes under mild conditions. The use of amides containing α‐protons in this catalytic reaction resulted in elimination to furnish enamines characterized by 1H‐NMR. This mild and selective process is compatible with nitriles, ethers, amines, and heterocyclic functionalities. However, competition experiments revealed poor tolerance for easily reducible functional groups, such as esters, ketones, and aldehydes. This transition metal‐free strategy presents a cheap and readily available process for the efficient reduction of tertiary amides to the corresponding aldehydes.
A Moisture‐Induced Electric Generator with High Output Voltage for Self‐Powered Wearable Electronics
Authors: Dinh Trung Vuong , Chen Si , Xia Hong , Natsuki Toshiaki , Ni Qing‐Qing 
Published: October 2022

AbstractHarnessing energy from ubiquitous moisture is of intense interest because of its considerable potential in self‐powered wearable electronics. However, most existing moisture‐electric generators (MEGs) have poor output voltage, which limits their application possibility. Herein, a novel moisture‐induced electric generator (MIEG) is successfully fabricated with highly‐efficient electric generation by simply bridging a graphene oxide (GO) film and a bilayer graphene oxide/graphite (GOGH) composite film by a polyvinyl alcohol‐phosphoric acid electrolyte gel. The GO film can effectively boost conductive ion diffusion in the electrolyte channel under moisture adsorption while the bilayer GOGH film enhances a potential between two electrodes and output results based on its hydrophilic GO layer and good conductive graphite layer. These availabilities result in an elevated voltage of 1.1 V and a high current of 25.4 μA (254 μA.cm−2), among the high‐level reported outputs. More excitingly, the device also extends without limit by integrating the MIEG cells into a series or parallel topology. As a breakthrough, MIEG is successfully used as a self‐powered wearable device by finger‐surface contact, proximity‐sensitive touchpads, and a human‐breathing transducer. This work not only opens a new futuristic clean power generation in moisture energy harvesting but also facilitates the development of new innovative, flexible electronics.
Solar‐Driven Catalytic Urea Oxidation for Environmental Remediation and Energy Recovery
Authors: Sun Wenbo , Zhang Meng , Li Jianan , Peng Chong 
Published: October 2022

AbstractInvited for this month′s cover is the group of Chong Peng at the Shanghai Jiao Tong University. The image shows how the solar‐driven catalytic urea conversion interconnects with the sustainable development of energy and environment. The Review itself is available at 10.1002/cssc.202201263.
Passive Daytime Radiative Cooling by Thermoplastic Polyurethane Wrapping Films with Controlled Hierarchical Porous Structures
Authors: Park Choyeon , Park Chanil , Park Sungmin , Lee Jaeho , Choi Jae‐Hak , Kim Yong Seok , Yoo Youngjae 
Published: October 2022

AbstractCurrent research has focused on effective solutions to mitigate global warming and the accelerating greenhouse gas emissions. Compared to most cooling methods requiring energy and resources, passive daytime radiative cooling (PDRC) technology offers excellent energy savings as it requires no energy consumption. However, existing PDRC materials encounter unprecedented problems such as complex structures, low flexibility, and performance degradation after stretching. Thus, this study reports a porous structured thermoplastic polyurethane (TPU) film with bimodal pores to produce high‐efficiency PDRC with efficient solar scattering using a simple process. The TPU film exhibited an adequately high solar reflectivity of 0.93 and an emissivity of 0.90 in the atmospheric window to achieve an ambient cooling of 5.6 °C at midday under a solar intensity of 800 W m−2. Thus, the highly elastic and flexible TPU film was extremely suitable for application on objects with complex shapes. The radiative cooling performance of 3D‐printed models covered with these TPU films demonstrated their superior indoor cooling efficiency compared to commercial white paint (8.76 °C). Thus, the proposed design of high‐efficiency PDRC materials is applicable in various urban infrastructural objects such as buildings and vehicles.
Classification of peripheral blood neutrophils using deep learning
Authors: Tseng Tser‐Rei , Huang Hsuan‐Ming 
Published: October 2022

AbstractDeep learning has been used to classify the while blood cells in peripheral blood smears. However, the classification of developing neutrophils is rarely studied. Moreover, it is still unknown whether deep learning can work well on the data coming from different sources. In this study, we therefore investigate the classification performance of deep learning for immature and mature neutrophils. In particular, we used three open‐access datasets obtained from different imaging systems: CellaVision DM 96, CellaVision DM 100, and iCELL ME‐150. A total of 26,050 images identified by one laboratory technologist were randomly split into training, validation, and testing datasets. A total of 10 convolutional neural networks were trained to classify six blood cell types: myeloblast, promyelocyte, myelocyte, metamyelocyte, banded neutrophil, and segmented neutrophil. The experimental results showed that compared to any single model, the average ensemble model could achieve a better classification performance and provide a testing accuracy of 90.1%. The sensitivity and specificity of the average ensemble model for the six blood cell types were above 83.5% and 96.9%, respectively. Our results suggest that deep learning is a promising tool for the classification of developing neutrophils, but further improvement is required.
Three‐ and five‐year follow‐up results of a randomized controlled trial on the effects of cognitive behavioral therapy before bariatric surgery
Authors: Paul Linda , van der Heiden Colin , van Hoeken Daphne , Deen Mathijs , Vlijm Ashley , Klaassen René , Biter L. Ulas , Hoek Hans W. 
Published: October 2022

AbstractObjectiveUp to 37% of bariatric surgery patients suffer from insufficient weight loss or weight regain and mental health symptoms in the longer term. Cognitive behavioral therapy (CBT) may be an effective adjunct intervention to optimize patients' psychological functioning and weight loss results. To examine the value of adding preoperative CBT to bariatric surgery, three‐ and five‐year follow‐up data are presented.MethodIn this multi‐center randomized controlled trial (RCT; N = 130), a CBT group was compared to a treatment‐as‐usual (TAU) control group. Measurements were conducted at five time points: pretreatment (T0) and posttreatment/presurgery (T1) and at one‐ (T2; N = 120), three‐ (T3; N = 117), and five‐year postsurgery (T4; N = 115). The intervention group received a 10‐weeks, individual, preoperative CBT focused on self‐monitoring, identifying triggers for disordered eating and goal setting for eating behavior and physical exercise, as well as postoperative lifestyle. Outcome measures included weight change, eating behavior, eating disorders, depression, quality of life (QoL), and overall psychological health.ResultsPreoperative CBT was not associated with better three‐ and five‐year results than TAU regarding weight, dysfunctional eating behaviors, eating disorders, depression, overall psychological health, and QoL.DiscussionContrary to our hypothesis, three‐ and five‐year postsurgery differences between groups regarding weight change and mental health were not significant.. Further exploration suggested that in both groups weight problems and depressive symptoms worsened at three and five‐year follow‐up. Future research should focus on long‐term postoperative monitoring of weight and mood and on associated postoperative interventions and their specific timing.Public SignificanceAfter bariatric surgery, in the longer term weight problems re‐occur in 30% of patients, which is probably partly related to psychopathology. We investigated whether cognitive behavior therapy (CBT) prior to bariatric surgery improved weight maintenance and mental health after surgery. Our study provided definite proof that preoperative CBT is not effective. Long‐term postoperative monitoring and prompt psychological intervention after first signs of deterioration, are important to prevent further problems.
Women's body dissatisfaction, physical appearance comparisons, and Instagram use throughout the COVID‐19 pandemic: A longitudinal study
Authors: Vall‐Roqué Helena , Andrés Ana , González‐Pacheco Himar , Saldaña Carmina 
Published: October 2022

AbstractObjectiveThis study aimed to determine the evolution of Instagram use, body dissatisfaction and physical appearance comparisons throughout the coronavirus disease‐2019 (COVID‐19) pandemic, and to explore whether there was a relationship between the changes in Instagram use throughout the pandemic and body dissatisfaction and physical appearance comparisons.MethodA total of 272 Spanish women (16–70 years old) were followed‐up across four waves of assessment between November 2019 (before the pandemic started) and July 2021. Body dissatisfaction, social appearance comparisons, and Instagram use were assessed using the Eating Disorders Inventory‐3, the Physical Appearance Comparison Scale‐Revised, and an ad hoc questionnaire for Instagram use, respectively.ResultsNo statistically significant changes were found in the frequency of Instagram use, nor on the proportion of women following appearance‐focused accounts on Instagram, among the data collection periods. Body dissatisfaction significantly increased from T1 to T4, and physical appearance comparisons significantly increased from T1 to T2, T3, and T4. These increases were not found to be significant for those with eating disorder risk. No significant differences were found in body dissatisfaction and physical appearance comparisons depending on whether participants' frequency of Instagram use had changed or remained the same, or whether they had started/stopped/continued following appearance‐focused accounts on Instagram during the pandemic.DiscussionWomen's body dissatisfaction and physical appearance comparisons seem to have increased throughout the pandemic. The experiences of individuals with eating disorder risk throughout the pandemic, and the relationship between the pandemic and Instagram use, might be complex and need further research.Public SignificanceThis study suggests that women's body dissatisfaction and physical appearance comparisons have increased throughout the COVID‐19 pandemic. However, this increase might not be as clear for those who had eating disorder risk before the pandemic. Instagram frequency of use, and the percentage of women following appearance‐focused accounts on Instagram, do not seem to have significantly increased. More research is needed to explore the impact of the pandemic.
Heart failure with preserved ejection fraction and non‐alcoholic fatty liver disease: new insights from bioinformatics
Authors: Wang Anzhu , Li Zhendong , Sun Zhuo , Wang Yifei , Fu Shuangqing , Zhang Dawu , Ma Xiaochang 
Published: October 2022

AbstractAimsHeart failure with preserved ejection fraction (HFpEF) and non‐alcoholic fatty liver disease (NAFLD) are related conditions with an increasing incidence. The mechanism of their relationship remains undefined. Here, we aimed to explore the potential mechanisms, diagnostic markers, and therapeutic options for HFpEF and NAFLD.Methods and resultsHFpEF and NAFLD datasets were downloaded from the Gene Expression Omnibus (GEO) database. Common differentially expressed genes (DEGs) were screened for functional annotation. A protein–protein interaction network was constructed based on the STRING database, and hub genes were analysed using GeneMANIA annotation. ImmuCellAI (Immune Cell Abundance Identifier) was employed for analysis of immune infiltration. We also used validation datasets to validate the expression levels of hub genes and the correlation of immune cells. To screen for diagnostic biomarkers, we employed the least absolute shrinkage and selection operator and support vector machine‐recursive feature elimination. Drug signature database was used to predict potential therapeutic drugs. Our analyses identified a total of 33 DEGs. Inflammation and immune infiltration played important roles in the development of both diseases. The data showed a close relationship between chemokine signalling pathway, cytokine–cytokine receptor interaction, calcium signalling pathway, neuroactive ligand–receptor interaction, osteoclast differentiation, and cyclic guanosine monophosphate‐protein kinase G signalling pathway. We demonstrated that PRF1 (perforin 1) and IL2RB (interleukin‐2 receptor subunit beta) proteins were perturbed by the diseases and may be the hub genes. The analysis showed that miR‐375 may be a potential diagnostic marker for both diseases. Our drug prediction analysis showed that bosentan, eldecalcitol, ramipril, and probucol could be potential therapeutic options for the diseases.ConclusionsOur findings revealed common pathogenesis, diagnostic markers, and therapeutic agents for HFpEF and NAFLD. There is need for further experimental studies to validate our findings.
Exploring the Potential of Metal–Organic Frameworks for the Separation of Blends of Fluorinated Gases with High Global Warming Potential
Authors: Sosa Julio E. , Malheiro Carine , Castro Paulo J. , Ribeiro Rui P. P. L. , Piñeiro Manuel M. , Plantier Frédéric , Mota José P. B. , Araújo João M. M. , Pereiro Ana B. 
Published: October 2022

AbstractThe research on porous materials for the selective capture of fluorinated gases (F‐gases) is key to reduce their emissions. Here, the adsorption of difluoromethane (R‐32), pentafluoroethane (R‐125), and 1,1,1,2‐tetrafluoroethane (R‐134a) is studied in four metal–organic frameworks (MOFs: Cu‐benzene‐1,3,5‐tricarboxylate, zeolitic imidazolate framework‐8, MOF‐177, and MIL‐53(Al)) and in one zeolite (ZSM‐5) with the aim to develop technologies for the efficient capture and separation of high global warming potential blends containing these gases. Single‐component sorption equilibria of the pure gases are measured at three temperatures (283.15, 303.15, and 323.15 K) by gravimetry and correlated using the Tóth and Virial adsorption models, and selectivities toward R‐410A and R‐407F are determined by ideal adsorption solution theory. While at lower pressures, R‐125 and R‐134a are preferentially adsorbed in all materials, at higher pressures there is no selectivity, or it is shifted toward the adsorption R‐32. Furthermore, at high pressures, MOF‐177 shows the highest adsorption capacity for the three F‐gases. The results presented here show that the utilization of MOFs, as tailored made materials, is promising for the development of new approaches for the selective capture of F‐gases and for the separation of blends of these gases, which are used in commercial refrigeration.