bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ecotourism Development in Sampangan Muncar Beach Banyuwangi
Authors: Mulyasuryani Ani , Waluyo Eko , Prananto Yuniar Ponco , Indrayani Erlinda 
Published: November 2022

Aims: This study aims to provide counseling on waste management and preservation of the coastal environment to support the development of ecotourism around Sampangan Beach as well as education using the pyrolysis method in waste management.
Study Design: To address the trash and ecotourism issues at Sampangan Beach, a pyrolysis device and a 3D model of the ecotourism beach were created.
Place and Duration of Study: This research was conducted at Sampangan Beach which is located in Sampangan Village, Muncar District, Banyuwangi Regency in June 2022 until July 2022.
Methodology: This study uses a qualitative approach by taking data through surveys to obtain facts from existing symptoms. Field observations and surveys of locals and visitors were conducted in preparation to ascertain the field circumstances at Sampangan Beach before constructing ecotourism beach tools and designs. Additionally, observations are done to learn about the issues, difficulties, and opportunities existing at the site. In addition, researchers read up on pyrolysis machinery and beach design in the literature. Waste management is carried out using the pyrolysis method. The population of this study is the apparatus of villages, environmental management, and communities living directly adjacent to coastal areas.
Results: Based on the analysis using a qualitative approach and waste management using the pyrolysis method, the results of the process of burning plastic waste using a pyrolysis tool are influenced by the type of plastic and the temperature of the reactor combustion. Pyrolysis combustion using 3 kg of LPG gas can be used in 3-4 waste-burning cycles, so this method is very good for reducing plastic waste, especially in the coastal area of Muncar Banyuwangi. As well as coastal communities with livelihoods as fishermen can reduce the cost of purchasing diesel by replacing fuel pyrolysis fuel when to catch fish. This 3D model concept that has been compiled follows the style of arranging places such as the beaches in Banyuwangi to increase tourist attraction and increase public comfort when traveling on Sampangan Beach.
Effect of Extraction Method from Brown Seaweeds Padina sp. on Quality of Alginate for Edible Film Application: A Review
Authors: Waluyo Eko 
Published: November 2022

Aims: This review aims to study the effect of the extraction method on the quality of the alginate extracted from Padina sp. and study its application for edible films.
Study Design: This research was conducted using a systematic literature review method.
Place and Duration of Study: Library sources are research articles that are available online and can be accessed through websites or search engines by entering keywords that are relevant to the topics.
Results: The results obtained are various information about the alginate of Padina sp seaweed extracted from several methods such as the acid pathway method, the potassium method without the addition of potassium hydroxide and the calcium method with the addition of potassium hydroxide, and the application of alginate for edible films. It is recommended that further research be carried out to obtain alginate results with more diverse extraction methods.
Reforming Reimbursement for the US Food and Drug Administration’s Accelerated Approval Program to Support State Medicaid Programs
Authors: Sachs Rachel E. , Donohue Julie M. , Dusetzina Stacie B. 
Published: November 2022

ImportanceThe US Food and Drug Administration (FDA) has an accelerated approval program that has become the subject of scholarly attention and criticism, not only for the FDA’s oversight of the program but also for its implications for payers.ObservationsState Medicaid programs’ legal obligations to provide reimbursement for accelerated approval products have created fiscal challenges for Medicaid that have been exacerbated by industry’s changing use of the accelerated approval program over time. Although strategies for accelerated approval reforms have been proposed, most focus on reforming the FDA’s accelerated approval pathway and product regulation without taking into account the implications of this pathway for state Medicaid programs. There is a need for policy reforms that balance the goal of speeding approval of important medicines with states’ real concerns regarding spending on medications with little evidence of clinical benefits. Areas of potential reform include formulary exclusion, Medicaid rebates, value-based pricing, and consolidated purchasing or carve outs.Conclusions and RelevancePolicy makers may wish to consider options for reforming reimbursement for accelerated approval products in addition to reforms to the FDA’s operation of the pathway. Policy reform proposals can provide a range of options to evaluate trade-offs of access and pricing.
Evaluation of Industry Payments to US Advanced Practice Clinicians in 2021
Authors: Singh Armaan , Hyman Max J. , Modi Parth K. 
Published: November 2022

ImportanceAdvanced practice clinicians (APCs) are a growing part of the US health care system, and their financial relationships with pharmaceutical and medical device companies have not been well studied.ObjectivesTo examine the value, frequency, and types of payments made to APCs and the association of state scope-of-practice laws with these payments.Design, Setting, and ParticipantsThis cross-sectional study used 2021 Open Payments Program data to analyze payments from pharmaceutical or medical device companies to physicians or APCs between January 1 and December 31, 2021. Doctors of medicine and osteopathy were categorized as physicians, and nurse practitioners, physician assistants, clinical nurse specialists, certified registered nurse anesthetists, certified nurse midwives, and anesthesiologist assistants as APCs.Main Outcomes and MeasuresThe total value and total number of payments were calculated in aggregate and per clinician for each type of APC, all APCs, and physicians. These calculations were repeated by submitting manufacturer, form of payment, nature of payment, and state scope-of-practice law for nurse practitioners, physician assistants, and physicians.ResultsA total of 412 000 physicians and 232 000 APCs collectively received $1.99 billion in payments from industry in 2021, of which APCs received $121 million (6.1%). The median total value of payments per clinician for physicians was $167 (IQR, $45-$712) and for APCs was $117 (IQR, $33-$357). The median total number of payments per clinician was equal for physicians and APCs (n = 4). The most common payments to APCs included food and beverage ($69 million [57.6%]), compensation for services other than consulting ($32 million [26.4%]), and consulting fees ($8 million [6.6%]). Advanced practice clinicians in states with the most restrictive scope-of-practice laws received 15.9% lower total value of payments than those in the least restrictive states (P = .002). Physician assistants received 7.6% (P = .005) higher value and 18.1% (P &amp;lt; .001) greater number of payments than nurse practitioners.Conclusions and RelevanceIn this cross-sectional study, 232 000 APCs collectively received $121 million in industry payments in 2021. The frequency of industry interactions with APCs was similar to that for physicians, but the average value was lower. The greater value of payments to APCs who practice in states with the least restrictive scope-of-practice laws suggests that industry payments may be related to clinician autonomy.
Early‐onset Alzheimer's disease shows a distinct neuropsychological profile and more aggressive trajectories of cognitive decline than late‐onset
Authors: Tort‐Merino Adrià , Falgàs Neus , Allen Isabel E. , Balasa Mircea , Olives Jaume , Contador José , Castellví Magdalena , Juncà‐Parella Jordi , Guillén Núria , Borrego‐Écija Sergi , Bosch Bea , Fernández‐Villullas Guadalupe , Ramos‐Campoy Oscar , Antonell Anna , Rami Lorena , Sánchez‐Valle Raquel , Lladó Albert 
Published: November 2022

AbstractObjectivesEarly‐ and late‐onset Alzheimer's disease (EOAD and LOAD) share the same neuropathological traits but show distinct cognitive features. We aimed to explore baseline and longitudinal outcomes of global and domain‐specific cognitive function in a well characterized cohort of patients with a biomarker‐based diagnosis.MethodsIn this retrospective cohort study, 195 participants were included and classified according to their age, clinical status, and CSF AD biomarker profile: 89 EOAD, 37 LOAD, 46 young healthy controls (age ≤ 65 years), and 23 old healthy controls (>65 years). All subjects underwent clinical and neuropsychological assessment, neuroimaging, APOE genotyping and lumbar puncture.ResultsWe found distinct neuropsychological profiles between EOAD and LOAD at the time of diagnosis. Both groups showed similar performances on memory and language domains, but the EOAD patients displayed worsened deficits in visual perception, praxis, and executive tasks (p < 0.05). Longitudinally, cognitive decline in EOAD was more pronounced than LOAD in the global outcomes at the expense of these non‐amnestic domains. We found that years of education significantly influenced the decline in most of the neuropsychological tests. Besides, the APOE ε4 status showed a significant effect on the decline of memory‐related tasks within the EOAD cohort (p < 0.05).InterpretationAge of onset is a main factor shaping the cognitive trajectories in AD patients, with younger age driving to a steeper decline of the non‐memory domains. Years of education are related to a transversal decline in all cognitive domains and APOE ε4 status to a specific decline in memory performance in EOAD.
Improved feature least mean square algorithm
Authors: Yazdanpanah Hamed 
Published: November 2022

SummaryIn this paper, we propose the improved feature least‐mean‐square (IF‐LMS) algorithm to exploit hidden sparsity in unknown systems. Recently, the feature least‐mean‐square (F‐LMS) algorithm has been introduced, but its application is limited to particular systems since it uses predetermined feature matrices. However, the proposed IF‐LMS algorithm utilizes the stochastic gradient descent (SGD) method to learn feature matrices; thus, it can be used in any system that the classical LMS algorithm is applicable. Hence, by employing a learnable feature matrix, the IF‐LMS algorithm has a vast application area as compared to the F‐LMS algorithm. Moreover, mathematically, we discuss some parameters of the IF‐LMS algorithm. Simulation results, in synthetic and real‐life scenarios, demonstrate that the IF‐LMS algorithm has superior filtering accuracy to the well‐known LMS algorithm.
High‐Loading Co Single Atoms and Clusters Active Sites toward Enhanced Electrocatalysis of Oxygen Reduction Reaction for High‐Performance Zn–Air Battery
Authors: Zhang Mengtian , Li Hao , Chen Junxiang , Ma Fei‐Xiang , Zhen Liang , Wen Zhenhai , Xu Cheng‐Yan 
Published: November 2022

AbstractThe development of precious‐metal alternative electrocatalysts for oxygen reduction reaction (ORR) is highly desired for a variety of fuel cells, and single atom catalysts (SACs) have been envisaged to be the promising choice. However, there remains challenges in the synthesis of high metal loading SACs (>5 wt.%), thus limiting their electrocatalytic performance. Herein, a facile self‐sacrificing template strategy is developed for fabricating Co single atoms along with Co atomic clusters co‐anchored on porous‐rich nitrogen‐doped graphene (Co SAs/AC@NG), which is implemented by the pyrolysis of dicyandiamide with the formation of layered g‐C3N4 as sacrificed templates, providing rich anchoring sites to achieve high Co loading up to 14.0 wt.% in Co SAs/AC@NG. Experiments combined with density functional theory calculations reveal that the co‐existence of Co single atoms and clusters with underlying nitrogen doped carbon in the optimized Co40SAs/AC@NG synergistically contributes to the enhanced electrocatalysis for ORR, which outperforms the state‐of‐the‐art Pt/C catalysts with presenting a high half‐wave potential (E1/2 = 0.890 V) and robust long‐term stability. Moreover, the Co40SAs/AC@NG presents excellent performance in Zn–air battery with a high‐peak power density (221 mW cm−2) and strong cycling stability, demonstrating great potential for energy storage applications.
Implied Open‐circuit Voltage Imaging via a Single Bandpass Filter Method—Its First Application in Perovskite Solar Cells
Authors: Soufiani Arman Mahboubi , Lee‐Chin Robert , Fassl Paul , Mahmud Md Arafat , Pollard Michael E. , Zheng Jianghui , Weber Juergen W. , Ho‐Baillie Anita , Trupke Thorsten , Hameiri Ziv 
Published: November 2022

AbstractA novel, camera‐based method for direct implied open‐circuit voltage (iVOC) imaging via the use of a single bandpass filter (s‐BPF) is developed for large‐area photovoltaic solar cells and precursors. The photoluminescence (PL) emission is imaged using a narrow BPF with centre energy inside the high‐energy tail of the PL emission, utilising the close‐to‐unity and nearly constant absorptivity of typical photovoltaic devices in this energy range. As a result, the exact value of the sample's absorptivity within the BPF transmission band is not required. The use of an s‐BPF enables a fully contactless approach to calibrate the absolute PL photon flux for spectrally integrated detectors, including cameras. The method eliminates the need for knowledge of the imaging system spectral response. Through an appropriate choice of the BPF centre energy, a range of absorber compositions or a single absorber with different surface morphologies, such as planar and textured, can be imaged, all without the need for additional detection optics. The feasibility of this s‐BPF method is first validated. The relative error in iVOC is determined to be ≤1.5%. The method is then demonstrated on device stacks with two different perovskite compositions commonly used in single‐junction and monolithic tandem solar cells.
An ECM‐Mimicking, Injectable, Viscoelastic Hydrogel for Treatment of Brain Lesions
Authors: Hu Yan , Jia Yuanbo , Wang Siwei , Ma Yufei , Huang Guoyou , Ding Tan , Feng Dayun , Genin Guy M. , Wei Zhao , Xu Feng 
Published: November 2022

AbstractBrain lesions can arise from traumatic brain injury, infection, and craniotomy. Although injectable hydrogels show promise for promoting healing of lesions and health of surrounding tissue, enabling cellular ingrowth and restoring neural tissue continue to be challenging. It is hypothesized that these challenges arise in part from the mismatch of composition, stiffness, and viscoelasticity between the hydrogel and the brain parenchyma, and this hypothesis is tested by developing and evaluating a self‐healing hydrogel that not only mimics the composition, but also the stiffness and viscoelasticity of native brain parenchyma. The hydrogel is crosslinked by dynamic boronate ester bonds between phenylboronic acid grafted hyaluronic acid (HA‐PBA) and dopamine grafted gelatin (Gel‐Dopa). This HA‐PBA/Gel‐Dopa hydrogel could be injected into a lesion cavity in a shear‐thinning manner with rapid hemostasis, high tissue adhesion, and efficient self‐healing. In an in vivo mouse model of brain lesions, the multi‐functional injectable hydrogel is found to support neural cell infiltration, decrease astrogliosis and glial scars, and close the lesions. The results suggest a role for extracellular matrix‐mimicking viscoelasticity in brain lesion healing, and motivate additional experimentation in larger animals as the technology progresses toward potential application in humans.
NIR‐II Responsive Upconversion Nanoprobe with Simultaneously Enhanced Single‐Band Red Luminescence and Phase/Size Control for Bioimaging and Photodynamic Therapy
Authors: Bi Shenghui , Deng Zhiming , Huang Junqing , Wen Xingwang , Zeng Songjun 
Published: November 2022

AbstractLanthanide based upconversion (UC) nanoprobes have emerged as promising agents for biological applications. Extending the excitation light to the second near‐infrared (NIR‐II), instead of the traditional 980/808 nm light, and realizing NIR‐II responsive single‐band red UC emission is highly demanded for bioimaging application, which has not yet been explored. Here, a new type of NIR‐II (1532 nm) light responsive UC nanoparticles (UCNPs) with enhanced single‐band red UC emission and controllable phase and size is designed by introducing Er3+ as sensitizer and utilizing Mn2+ as energy manipulator. Through tuning the content of Mn2+ in NaLnF4:Er/Mn, the crystal phase, size, and emitting color are readily controlled, and the red‐to‐green (R/G) ratio is significantly increased from ≈20 to ≈300, leading to NIR‐II responsive single band red emission via efficient energy transfer between Er3+ and Mn2+. In addition, the single band red emitting intensity can be further improved by coating shell to avoid the surface quenching effect. More importantly, NIR‐II light activated red UC bioimaging and photodynamic therapy through loading photosensitizer of zinc phthalocyanine are successfully achieved for the first time. These findings provide a new strategy of designing NIR‐II light responsive single‐band red emissive UCNPs for biomedical applications.
Progress and Prospects of Inorganic Solid‐State Electrolyte‐Based All‐Solid‐State Pouch Cells
Authors: Wang Changhong , Kim Jung Tae , Wang Chunsheng , Sun Xueliang 
Published: November 2022

AbstractAll‐solid‐state batteries have piqued global research interest because of their unprecedented safety and high energy density. Significant advances have been made in achieving high room‐temperature ionic conductivity and good air stability of solid‐state electrolytes (SSEs), mitigating the challenges at the electrode–electrolyte interface, and developing feasible manufacturing processes. Along with the advances in fundamental study, all‐solid‐state pouch cells using inorganic SSEs have been widely demonstrated, revealing their immense potential for industrialization. This review provides an overview of inorganic all‐solid‐state pouch cells, focusing on ultrathin SSE membranes, sheet‐type thick solid‐state electrodes, and bipolar stacking. Moreover, several critical parameters directly influencing the energy density of all‐solid‐state Li‐ion and lithium–sulfur pouch cells are outlined. Finally, perspectives on all‐solid‐state pouch cells are provided and specific metrics to meet certain energy density targets are specified. This review looks to facilitate the development of inorganic all‐solid‐state pouch cells with high energy density and excellent safety.
Engineering Electrodes with Robust Conducting Hydrogel Coating for Neural Recording and Modulation
Authors: Zhang Jiajun , Wang Lulu , Xue Yu , Lei Iek Man , Chen Xingmei , Zhang Pei , Cai Chengcheng , Liang Xiangyu , Lu Yi , Liu Ji 
Published: November 2022

AbstractCoating conventional metallic electrodes with conducting polymers has enabled the essential characteristics required for bioelectronics, such as biocompatibility, electrical conductivity, mechanical compliance, and the capacity for structural and chemical functionalization of the bioelectrodes. However, the fragile interface between the conducting polymer and the electrode in wet physiological environment greatly limits their utility and reliability. Here, a general yet reliable strategy to seamlessly interface conventional electrodes with conducting hydrogel coatings is established, featuring tissue‐like modulus, highly‐desirable electrochemical properties, robust interface, and long‐term reliability. Numerical modeling reveals the role of toughening mechanism, synergy of covalent anchorage of long‐chain polymers, and chemical cross‐linking, in improving the long‐term robustness of the interface. Through in vivo implantation in freely‐moving mouse models, it is shown that stable electrophysiological recording can be achieved, while the conducting hydrogel–electrode interface remains robust during the long‐term low‐voltage electrical stimulation. This simple yet versatile design strategy addresses the long‐standing technical challenges in functional bioelectrode engineering, and opens up new avenues for the next‐generation diagnostic brain‐machine interfaces.
Tracking Mechanical Stress and Cell Migration with Inexpensive Polymer Thin‐Film Sensors
Authors: Finney Tanner J. , Frank Skye L. , Bull Michael R. , Guy Robert D. , Kuhl Tonya L. 
Published: November 2022

AbstractPolydiacetylene (PDA) Langmuir films are well known for their blue‐to‐red chromatic transitions in response to a variety of stimuli, including UV light, heat, bio‐molecule bindings, and mechanical stress. In this work, the ability to tune PDA Langmuir films to exhibit discrete chromatic transitions in response to applied mechanical stress is detailed. Normal and shear‐induced transitions are quantified using the Surface Forces Apparatus and established to be binary and tunable as a function of film formation conditions. Both monomer alkyl tail length and metal cations are used to manipulate the chromatic transition force threshold to enable discrete force sensing from ≈50 to ≈500 nN µm−2 for normal loading and ≈2 to ≈40 nN µm−2 for shear‐induced transitions, which are appropriate for biological cells. The utility of PDA thin‐film sensors is demonstrated with the slime mold Physarum polycephalum. The fluorescence readout of the films enabled: the area explored by Physarum to be visualized, the forces involved in locomotion to be quantified, and revealed novel puncta formation potentially associated with Physarum sampling its environment.
Printing of Low‐Melting‐Point Alloy as Top Electrode for Organic Solar Cells
Authors: Yu Boyang , Liu Linna , Liu Bingyang , Zhao Xinyan , Deng Weiwei 
Published: November 2022

AbstractThe top electrodes of organic solar cells (OSCs) are usually deposited by thermal evaporation in vacuum, which has become the major obstacle toward fully‐printed OSCs. The vacuum‐free printed top electrodes are highly desirable for the continuous production of OSCs. Here, the printing of low‐melting‐point alloy (LMPA) as cathodes in OSCs based on the D18:Y6 system is investigated. The Field's metal (FM) is focused with a melting point of 62 °C, which could be printed under moderate temperatures that are harmless to the active layers and solidifies at room temperature. More importantly, FM will not melt by solar radiation under practical scenarios. Direct ink writing is used to print the FM cathodes. Two printing modes are identified: the dragging mode in the far field to obtain rod electrodes, and the shearing mode in the near field to achieve relatively flat lamellas. The correlations between processing parameters and properties of the printed electrodes are elucidated. OSCs with printed FM cathodes exhibit the highest power conversion efficiency of 16.44%. The results demonstrate that this facile and robust direct LMPA writing technique is promising for high‐performance fully‐printed OSCs.