bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effectiveness and Safety of Dose‐Specific DOACs in Patients With Atrial Fibrillation: A Systematic Review and Network Meta‐Analysis
Authors: Oh Sang-Hyeon , Cheon Seunghyun , Choi Seo-Yong , Kim Young Seo , Choi Han-Gon , Chung Jee-Eun 
Published: January 2025

Background: Dose adjustments of direct‐acting oral anticoagulants (DOACs) for atrial fibrillation are based on pivotal clinical trials assessing their effectiveness and safety in controlled settings. However, the appropriateness of these dosing strategies in real‐world practice is uncertain. The purpose of this study is to compare the effectiveness and safety of dose‐specific DOACs with those of warfarin.Methods: This study retrieved articles from MEDLINE, Embase, and CENTRAL until March 5, 2024. Primary outcomes were the incidence of stroke/systemic embolisms (S/SEs) and major bleeding (MB). Direct pairwise meta‐analyses compared each dose‐specific DOAC with warfarin. Heterogeneity was assessed using Higgin’s I2 and Q statistics, while publication bias was evaluated through funnel plots and Begg’s and Egger’s tests, with adjusted pooled estimates calculated via trim‐and‐fill and precision‐effect estimate with standard error (PET‐PEESE) methods. A network analysis was conducted, with additional comparisons made using a Bayesian random‐effects model for indirect evidence.Results: A total of 32 studies with 2,332,770 patients were included. Both standard‐dose (SD) and low‐dose (LD) DOACs significantly reduced S/SE, except for LD apixaban and LD edoxaban. Rivaroxaban did not show significant difference in MB compared to warfarin. In East Asian patients, all doses of DOACs exhibited lower hazard ratios (HRs) for S/SE and MB than those observed in the primary analysis, with LD rivaroxaban significantly reducing MB, a finding not observed in the primary analysis. Rank probability analysis indicated that the dose‐specific DOACs had different safety profiles and small but meaningful differences in effectiveness. SD apixaban (S/SE: second, MB: second) and edoxaban (S/SE: first, MB: fourth) and LD edoxaban (S/SE: fourth, MB: first) had high ranks. LD apixaban had the most significant difference in rank for S/SE from SD apixaban, ranking eighth compared to second.Conclusions: This study found that all DOACs provided comparable or superior effectiveness and safety to warfarin. SD apixaban, SD edoxaban, and LD edoxaban achieved a favorable balance between preventing S/SE and MB risk.
Comprehensive Analysis of FBXO43 Expression and Its Prognostic and Therapeutic Implications in Osteosarcoma
Authors: Jin Jiang , Yao Kang , Tingxiao Zhao , Longtao Yao , Yanlei Li , Jinlong Tian , Xiaojun Zhu , Liang Han 
Published: January 2025

Background: Osteosarcoma (OS) is the most common malignant bone tumor in children and adolescents. FBXO43, a member of the F‐box protein family, has been identified as a crucial prognostic factor in several cancers. However, its role in osteosarcoma remains largely unexplored.Methods: This study investigated the expression and potential role of FBXO43 across the TCGA pan‐cancer cohort, with a particular focus on sarcoma (SARC). We analyzed the relationship between FBXO43 expression and various cancer‐related pathways, immune infiltration, and genomic features, including TP53 mutations. We also conducted immunotherapy predictive analyses using TIDE and Submap algorithms. To validate our findings, we performed a series of in vitro experiments, including cell invasion and wound healing assays.Results: FBXO43 was found to be significantly overexpressed in various cancers and was particularly associated with pathways such as E2F_TARGETS and G2M_CHECKPOINT in SARC samples. Differential FBXO43 expression was linked to distinct immune infiltration patterns and pathway enrichments. Notably, high FBXO43 expression in osteosarcoma was associated with a higher TP53 mutation rate. Predictive analyses indicated that patients with low FBXO43 expression had better immunotherapy responses, suggesting its potential as a diagnostic and prognostic biomarker. These findings were corroborated by our in vitro functional assays.Conclusion: Our comprehensive analysis reveals that FBXO43 plays a critical role in the progression of osteosarcoma, impacting both immune infiltration and genomic stability. FBXO43 expression levels may serve as valuable biomarkers for predicting immunotherapy responses in osteosarcoma patients. Future studies should aim to elucidate the molecular mechanisms driving FBXO43’s role and validating these findings in clinical settings to develop targeted therapeutic strategies.
Marijuana Poisoning in Canines in the Aburrá Valley (Antioquia‐Colombia), 2023‐2024
Authors: Marulanda Natalia Restrepo , Álvarez José Fernando Ortiz , Puerta Jaime Humberto Londoño , Peralta Angélica María Blandón , Corrales Natalia Uribe 
Published: January 2025

Background and Aim: Marijuana poisoning in canines is still considered a taboo topic. Poisoning in pets is becoming increasingly common, in many cases resulting in severe clinical signs, such as ataxia, urinary incontinence, mydriasis, depression, and hyperesthesia. Colombia does not have any reliable test for the diagnosis of exposure to cannabis in animals, and it is not an obligation to report this kind of poisoning to the authorities. Therefore, the main objective of this study was to determine the frequency of cases compatible with tetrahydrocannabinoid (THC) poisoning in canines in the Aburrá valley (Antioquia‐Colombia), 2023‐2024.Materials and Methods: A cross‐sectional study was conducted in the Aburrá valley (Antioquia‐Colombia) from 2023 to 2024. Veterinary centers that were allowed to participate were visited, and the clinical records were examined on the canines that were diagnosed positive for marijuana poisoning. We examined the clinical record for different risk factors that could explain the poisoning. A descriptive statistic and a Chi‐square test were used to identify risk factors; p < 0.05 were considered statistically significant.Results: One hundred and thirteen (113) cases compatible with cannabis poisoning were found in dogs. Puppies, crossbreeds, trim sizes, and canines whose owners have middle or high economic incomes were the most affected. In addition, a relation between the route of possible cannabis poisoning and the severe presentation of clinical signs was found, with ingestion and inhalation being the routes that generated a more pronounced sign. Likewise, a relationship between age and the most probable route of exposure was found, finding that puppies were more related to the ingestion of cannabis products.Conclusion: This is the first article in Colombia that was focused on determining the frequency of possible cannabis poisoning in canines. The dogs that are more susceptible to suffering cannabis poisoning are puppies and small‐size dogs that are attended by veterinary medical centers and are in neighborhoods that are recognizable by people who have high salaries.
Mucin 5AC Promotes Breast Cancer Brain Metastasis through cMET/CD44v6
Authors: Maurya Shailendra Kumar , Jaramillo-Gómez Jenny A. , Rehman Asad Ur , Gautam Shailendra Kumar , Fatima Mahek , Khan Md Arafat , Zaidi Mohd Ali Abbas , Khan Parvez , Anwar Laiba , Alsafwani Zahraa Wajih , Kanchan Ranjana K. , Mohiuddin Sameer , Pothuraju Ramesh , Vengoji Raghupathy , Chirravuri Venkata Ramakanth , Natarajan Gopalakrishnan , Bhatia Rakesh , Atri Pranita , Perumal NaveenKumar , Chaudhary Sanjib , Lakshmanan Imayavaramban , Mahapatra Sidharth , Talmon Geoffrey A. , Cox Jesse L. , Smith Lynette M. , Santamaria-Barria Juan A. , Ganti Apar Kishor , Siddiqui Jawed Akhtar , Cittelly Diana M. , Batra Surinder Kumar , Nasser Mohd Wasim 
Published: January 2025

Abstract

Purpose:
Breast cancer brain metastasis remains a significant clinical problem. Mucins have been implicated in metastasis; however, whether they are also involved in breast cancer brain metastasis remains unknown. We queried databases of patients with brain metastasis and found mucin 5AC (MUC5AC) to be upregulated and therefore sought to define the role of MUC5AC in breast cancer brain metastasis.

Experimental Design:
In silico dataset analysis, RNA-sequence profiling of patient samples and cell lines, analysis of patient serum samples, and in vitro/in vivo knockdown experiments were performed to determine the function of MUC5AC in breast cancer brain metastasis. Coimmunoprecipitation was used to unravel the interactions that can be therapeutically targeted.

Results:
Global in silico transcriptomic analysis showed that MUC5AC is significantly higher in patients with breast cancer brain metastasis. Analysis of archived breast cancer brain metastasis tissue further revealed significantly higher expression of MUC5AC in all breast cancer subtypes, and high MUC5AC expression predicted poor survival in HER2+ breast cancer brain metastasis. We validated these observations in breast cancer brain metastatic cell lines and tissue samples. Interestingly, elevated levels of MUC5AC were detected in the sera of patients with breast cancer brain metastasis. MUC5AC silencing in breast cancer brain metastatic cells reduced their migration and adhesion in vitro and in brain metastasis in the intracardiac injection mouse model. We found high expression of cMET and CD44v6 in breast cancer brain metastasis, which increased MUC5AC expression via hepatocyte growth factor signaling. In addition, MUC5AC interacts with cMET and CD44v6, suggesting that MUC5AC promotes breast cancer brain metastasis via the cMET/CD44v6 axis. Inhibition of the MUC5AC/cMET/CD44v6 axis with the blood–brain barrier–permeable cMET inhibitor bozitinib (PLB1001) effectively inhibits breast cancer brain metastasis.

Conclusions:
Our study establishes that the MUC5AC/cMET/CD44v6 axis is critical for breast cancer brain metastasis, and blocking this axis will be a novel therapeutic approach for breast cancer brain metastasis.
Scepticism towards Islam or religiosity? An experimental approach to exploring scepticism towards Muslims in Norway
Authors: Bell David Andreas , Fladmoe Audun , Valenta Marko 
Published: January 2025

Abstract
Muslims in Europe tend to have an immigrant background. Consequently, they often face a twofold challenge: they are subjected to the prejudice and discrimination immigrants in general face alongside prejudice directed toward them as a religious minority. In this study, we explore the role of Muslims' religiosity and how it relates to scepticism towards Muslims. We apply an online split-sample survey experiment conducted in 2021 to investigate Norwegians' attitudes toward individuals with different strengths of religious faith, ranging from a moderate to a strong Muslim faith. In addition, we explore how attitudes towards Muslims compare to the same attitudes towards individuals with similar Christian beliefs. Three main explanations are proposed for explaining these attitudes: socio-demographic aspects, religiosity, and scepticism towards immigration. We find that there is considerable scepticism towards Islam within Norwegian society, also when compared to other religions. Moreover, we find that those who are sceptical of immigration view Muslims in general as inherently strongly religious. In contrast, those who hold more positive views of immigration tend to consider Muslims in general as inherently moderate. This may suggest that an underlying aspect of why discussions surrounding Muslims within contemporary Europe seem to be so polarized is because different segments of society have a different understanding of what a Muslim actually is.
Structure–function coupling and decoupling during movie watching and resting state: Novel insights bridging EEG and structural imaging
Authors: Subramani Venkatesh , Lioi Giulia , Jerbi Karim , Farrugia Nicolas 
Published: January 2025

Abstract
The intricate structural and functional architecture of the brain enables a wide range of cognitive processes ranging from perception and action to higher order abstract thinking. Despite important progress, the relationship between the brain’s structural and functional properties is not yet fully established. In particular, the way the brain’s anatomy shapes its electrophysiological dynamics remains elusive. The electroencephalography (EEG) activity recorded during naturalistic tasks is thought to exhibit patterns of coupling with the underlying brain structure that vary as a function of behavior. Yet these patterns have not yet been sufficiently quantified. We address this gap by jointly examining individual Diffusion-Weighted Imaging (DWI) scans and continuous EEG recorded during video watching and resting state, using a Graph Signal Processing (GSP) framework. By decomposing the structural graph into eigenmodes and expressing the EEG activity as an extension of anatomy, GSP provides a way to quantify the structure–function coupling. We elucidate how the structure shapes function during naturalistic tasks such as movie watching and how this association is modulated by tasks. We quantify the coupling relationship in a region-, time-, and frequency-resolved manner. First of all, our findings indicate that the EEG activity in the sensorimotor cortex is strongly coupled with brain structure, while the activity in higher order systems is less constrained by anatomy, that is, shows more flexibility. In addition, we found that watching videos was associated with stronger structure–function coupling in the sensorimotor cortex, as compared with resting-state data. Second, time-resolved analysis revealed that the unimodal systems undergo minimal temporal fluctuation in structure–function association, and the transmodal system displays the highest temporal fluctuations, with the exception of PCC seeing low fluctuations. Lastly, our frequency-resolved analysis revealed a consistent topography across different EEG rhythms, suggesting a similar relationship with the anatomical structure across frequency bands. Together, this unprecedented characterization of the link between structure and function using continuous EEG during naturalistic behavior underscores the role of anatomy in shaping ongoing cognitive processes. Taken together, by combining the temporal and spectral resolution of EEG and the methodological advantages of GSP, our work sheds new light on the anatomo-functional organization of the brain.
Damage initiation strengths for the mesoscale lamina damage model of fiber-reinforced polymer composite laminates
Authors: Ariff Intanfifizieana M , Ahmad Zaini , Gan Khong W , Petrů Michal , Koloor Seyed S R , Tamin Mohd N 
Published: January 2025

The damage initiation criteria based on Hashin’s theory for fiber-reinforced composite lamina are refined by replacing the fracture strengths with the respective damage initiation strengths. The damage initiation strengths of the carbon fiber-reinforced (CFRP) composite lamina under tension and compression are comparable to the respective fracture strength. Thus, emphasis is placed on the measured nonlinear longitudinal shear response of the lamina. Results show that the damage initiation strength for longitudinal shear at 47.2 MPa is 43.5% lower than the lamina shear strength. The pure shear stress state at the mid-length gage region of the V-notch test coupon is maintained up to damage initiation, after which the fibers rotate and induce the normal strain components. The outcomes of the computational model fit the second-order description of the lamina damage initiation criteria and the expected post-damage stiffness reduction of the laminate coupon. The damage model is validated by the comparable measured and finite element (FE)-predicted load-displacement curves to fracture of the laminate coupon. The FE-computed and measured shear strain field using the digital image correlation (DIC) method is similar. In addition, the FE-calculated anti-symmetric matrix tensile damage distribution at the notches in the observed locations of the initial matrix cracks is consistent.
Implementing Oncologic Nursing Care Plans in Electronic Health Records With Two Taxonomies: A Pilot Study
Authors: Togni Serena , Saracino Lucia , Cieri Mariangela , Bianco Rosita , Terzoni Stefano , Giulia Santini Magda , Zito Emanuela , Lusignani Maura , Silvia Pazzaglia Maria , Depalma Letizia 
Published: January 2025

Background: Nursing care plans document the nursing process, displaying actions, and illustrating expected outcomes. Their integration into electronic health records (EHRs) is critical for accurate documentation, enhanced by standardized nursing terminologies that promote communication, critical reasoning, and patient safety through consistent language for information. Objective: This study aimed to identify appropriate standardized nursing terminology tailored to the context of a Northern Italian Cancer Center and research facility for developing nursing care plans and starting their integration into institutional EHRs. Methods: Participatory action research was conducted to select proper terminology respecting the oncological setting, develop nursing care plans, and start their implementation in EHRs. The nursing team of a pilot ward collaborated closely with the researchers as coresearchers. Care plan samples were presented using the North American Nursing Diagnosis Association-International Nursing Intervention Classification, Nursing Outcomes Classification, and International Classification for Nursing Practice (ICNP) in the test section of the EHRs to gather nurses’ preferences. Quantitative data collection, focus groups, and survey analyses were conducted. Results: Nurses chose the ICNP for its flexibility but sought better methods to define patient severity in assessments and outcomes. They suggested incorporating the Common Terminology Criteria for Adverse Events to enable context-sensitive care plans. Conclusions: End-user involvement is essential for developing EHRs, enhancing system usability, and reducing implementation resistance. Including nurses in management decisions empowers them, and improves care quality.
Del Nido versus conventional blood cardioplegia in tetralogy of fallot repair: A systematic review and meta-analysis of randomized controlled trials
Authors: Consoli Leo Noanh , Koziakas Ilias Georgios , Kanakis Meletios 
Published: January 2025

Objectives Compare outcomes of Del Nido (DN) versus conventional blood cardioplegia (BC) in the surgical repair of Tetralogy of Fallot (ToF). Methods Medical databases were searched to identify relevant clinical trials. Meta-analysis was conducted for primary (cardiopulmonary bypass [CPB] and aortic cross-clamp [ACC] times, hospital and intensive care unit [ICU] length of stay [LOS], mechanical ventilation time) and secondary (adverse events, lactate levels, volume of additional cardioplegia) endpoints. Analysis was conducted for DN versus conventional blood cardioplegia, and we performed sensitivity analysis with leave one-out analysis for the primary outcome. Results 4 randomized controlled trials were included ( n = 275). Mean differences (MD) with 95% confidence intervals (CI) were calculated with a random-effects model. Groups had similar CPB (MD −5.76 minutes; [−23.32 to 11.80]; p = 0.52) and ACC (MD 3.06 minutes; [−13.64 to 7.52]; p = 0.57) times, ICU (MD −6.42 hours; [−25.62 to 12.78]; p = 0.51) LOS and additional cardioplegia volume (MD −195.18 mL; [−434.19 to 43.82]; p = 0.11). The DN group had shorter hospital LOS (MD −0.81 days; [−1.25 to −0.36]; p = 0.0003) and time under mechanical ventilation (MD −4.57 hours; [−8.73 to −0.42]; p = 0.03). There was no difference in mortality. Conclusions DN cardioplegia has similar clinical outcomes and operative times compared to conventional blood cardioplegia in ToF surgery.
Exploring “good days” with advanced cancer: A pilot daily diary study
Authors: Lazris David , Fedor Jennifer , Cheng Svea , Bartel Christianna , Durica Krina C , Chen Leeann , Low Carissa A 
Published: January 2025

Background: People with Stage IV cancer face physical and emotional challenges impacting quality of life. Conventional quality of life measures do not capture daily fluctuations in patient well-being. Aim: This pilot study used daily diaries to explore the concept of a “good day” living with advanced cancer and to identify activities associated with “good days” as well as associations between daily “goodness” and conventional quality of life measures. Design: Twenty participants with Stage IV cancer completed daily diaries on a mobile app over a 14-day period. Participants rated each day’s “goodness” and documented daily activities. Statistical analyses examined associations between daily “goodness” ratings, activities, and baseline quality of life measures from the Patient-Reported Outcomes Measurement Information System (PROMIS). Setting/participants: Participants were recruited from oncology clinics and online research registries. Inclusion criteria included age over 18 years old, having Stage IV cancer, and owning a smartphone. Results: Analysis of 178 completed surveys from 18 participants revealed overall average “goodness” ratings exhibited more within-person than between-person variability. Average goodness was positively related to the PROMIS domain of Ability to Participate in Social Roles/Activities and negatively related to PROMIS domains of Anxiety and Depression. Participants reported better days when they engaged in leisure activities and worse days when they spent time managing physical symptoms. Conclusions: This study highlights the importance of understanding day-to-day quality of life in individuals with advanced cancer. Further research is needed to assess quality of life longitudinally and to develop personalized supportive and palliative care interventions in this population.
A feasibility study of measuring maternal anaemia and postoperative outcomes after caesarean section
Authors: O’Donnell Mark , Dennis Alicia T 
Published: January 2025

Summary Iron-deficiency anaemia (IDA) is a global health problem. The impact of IDA on outcomes in obstetric patients who undergo caesarean section (CS) is unknown. We assessed the feasibility of conducting a large study to investigate perioperative anaemia and outcomes after CS. With ethics approval and trial registration, 60 obstetric patients (30 planned CS, 30 emergency CS) were included. Feasibility categories were willingness to participate in a study, to undergo additional blood tests (haemoglobin, ferritin), to have weight measured and to undertake quality of recovery (QoR) questionnaires. Of eligible people approached, 100% agreed to participate and 100% would participate in a future study. Ninety percent (95% confidence interval (CI) 82.4% to 97.6%) and 83% (95% CI 73.9% to 92.7%) agreed to additional tests in hospital and after discharge, respectively. Ninety-eight per cent (95% CI 95.1% to 100%) consented to being weighed, and 100% completed QoR questionnaires. Preoperatively, 8.5% (95% CI 1.4% to 15.6%) of participants were anaemic. Postoperative haemoglobin was measured in only 22 (36.7%, 95% CI 24.5% to 48.9%) participants, and 40.9% (95% CI 20.4% to 61.5%) were anaemic, suggesting at least a quadrupling of the proportion of anaemic patients from pre- to postoperatively. Ferritin was not measured postoperatively in any participant. The prevalence of participants discharged with IDA was unquantifiable. Postoperative IDA in obstetric patients is likely to be a serious problem that is currently unrecognised. Our data suggest that a definitive study to determine associations between maternal anaemia and perioperative outcomes after CS surgery is feasible.