bluuebunny/crossref_metadata_2025_split huggingface dataset:
Engineering Surface Oxophilicity of Copper for Electrochemical CO2 Reduction to Ethanol
Authors: Li Minhan , Song Nan , Zhang Fangzhou , Luo Wei , Chen Jun , Jiang Wan , Yang Jianping 
Published: April 2022

Abstract
Copper-based materials is known for converting CO2 into deep reduction products via electrochemical reduction reaction (CO2RR). As the major multicarbon products (C2+), ethanol (C2H5OH) and ethylene (C2H4) are believed to share a common oxygenic intermediate according to theoretical studies, while the key factors that bifurcate C2H5OH and C2H4 pathways on Cu-based catalysts are not fully understood. Here, we propose a surface oxophilicity regulation strategy to enhance C2H5OH production in CO2RR, demonstrating by a Cu-Sn bimetallic system. Compared with bare Cu catalyst, the Cu-Sn bimetallic catalysts show improved C2H5OH but suppressed C2H4 selectivity. The experimental results and theoretical calculations demonstrate that the surface oxophilicity of Cu-Sn catalysts plays an important role in steering the protonation of the key oxygenic intermediate and guides the reaction pathways to C2H5OH. This study provides new insights into the electrocatalyst design for enhanced production of oxygenic products from CO2RR by engineering the surface oxophilicity of copper-based catalysts.
Circulating expression and clinical significance of LncRNA ANRIL in diabetic kidney disease
Authors: Zhu Yanting , Dai Lixia , Yu Xiangyou , Chen Xintian , Li Zhenjiang , Sun Yan , Liang Yan , Wu Bing , Wang Qiong , Wang Xiaoming 
Published: April 2022

Abstract
Background: Long noncoding RNA ANRIL has been found to be involved in the pathogenesis of diabetic kidney disease (DKD) and is expected to be a new target for prevention of DKD. However, the circulating expression and clinical significance of ANIL in DKD patients is uncertain. This study aims to explore this issue. Methods: The study consisted of 20 healthy controls, 22 T2DM patients (normalbuminuria) and 66 DKD patients (grouped as follows: microalbuminuria, n=23; macroalbuminuria, n=22 and renal dysfunction, n=21). The expressions of ANRIL in peripheral blood of all participants were measured by RT-qPCR. Results: The expression of ANRIL was significantly up-regulated in DKD patients (microalbuminuria, macroalbuminuria and renal dysfunction groups) than that in healthy control group. ANRIL was also over-expressed in macroalbuminuria and renal dysfunction groups in comparison with normalbuminuria group. ANRIL expression was positively correlated with Scr, BUN, CysC, urine β2-MG and urine α1-MG; while negatively correlated with eGFR in DKD patients. In addition, ANRIL was the risk factor for DKD with OR value of 1.681. The AUC of ANRIL in identifying DKD was 0.922, and the sensitivity and specificity of DKD diagnosis 83.3% and 90.5%, respectively. Conclusions: Our results indicated that highly expressed ANRIL in peripheral blood is associated with progression of DKD. Circulating ANRIL is an independent risk factor of DKD and has a highly predictive value in identifying DKD.
Advanced fabrication and multi-properties of recycled textile waste fibers aerogels
Authors: Dong Chunlei , Hu Yangzhao , Zhu Yuxuan , Wang Jiale , Jia Xuerui , Chen Jianbing , Li Jingliang 
Published: April 2022

Abstract
In recent years, the treatment of textile waste has been attracted more and more attention around the world. The reuse of textile waste can contribute to the reduction of carbon emissions and the sustainable development of the economy. Herein, we proposed a facile and cost-effective approach to fabricating aerogel by using textile waste fibers as the matrix and polyvinyl alcohol (PVA) and glutaraldehyde (GA) as crosslinking agents. After coated with methyltrimethoxysilane (MTMS) via chemical vapor deposition, both the interior and exterior of the whole textile waste aerogels surface exhibit a super-hydrophobic property with a water contact angle of up to 136.9°. A comprehensive investigation of its structure, thermal performance and oil absorption capacity has been carried out for high-value applications such as building insulation and oil spill cleanup. The textile waste fibers aerogels have ultra-low density and high porosity, good thermal stability and outstanding heat insulation properties (K avg = 0.049–0.061 W/m·K). It has a competitive commercial application value that the maximum oil absorption value reaches 18.6 g/g.
Boric Acid supplementation promoting the development of in vitro produced mouse embryos
Authors: Taskin Ali Cihan , Kocabay Ahmet , Gul Seref , Sahin Gizem Nur , Karahuseyinoglu Sercin , Kavakli Ibrahim Halil , Sogut Ibrahim 
Published: April 2022

Abstract
Boric acid (BA) is an important mineral for plants in nature, animals and human to help metabolic functions. Boric acid has both positive and negative effects on biological systems. In the literature, there is no publication about boric acid effect on preimplantation mouse embryo about in vitro developments. The aim of the present work was to investigate the effects of different concentrations of boric acid added to prior in vitro cytotoxicity for beneficial doses and later the mouse embryo culture media for antioxidant levels, the embryo quality, in vitro development rate and related genes. Superovulated C57Bl6/6j female mice were sacrificed ~18 hours after human chorionic gonadotropin (hCG) injection. Single cell stage embryos were collected from the oviducts and the embryos were divided experiment groups and cultured in embryo medium supplemented BA+ in 5% CO2, 37°C until 96-120 h at the blastocyst stage. The blastocyst development rates of 0, DMSO, 10-2, 10-3, 10-4, and 10-5 ppm BA were 51.52% (34/66), 45.00% (9/20), 72.62% (36/49), 77.48% (41/53) and 81.15% (43/53), respectively. The in vitro development rates were significantly higher in the 10-2, 10-3, 10-4 ppm compared with 0 (control) (p<0.05) and 10-5 ppm BA significantly higher compared with control group (p<0.01). With these results, after determining the non-cytotoxic doses of BA, low doses influence embryo development by positively affecting in vitro development rates, embryo cell numbers, biochemical parameters, development at molecular level. Therefore, boric acid seems to play an important role on the in vitro embryo development.
Fine mapping and candidate gene analysis of gummy stem blight resistance in cucumber stem
Authors: Han Jianan , Dong Shaoyun , Shi Yanxia , Miao Han , Liu Xiaoping , Beckles Diane M. , Gu Xingfang , Zhang Shengping 
Published: April 2022

Abstract
Gummy stem blight (GSB) is a serious fungal disease caused by Didymella bryoniae, that affects cucumber yield and quality worldwide. However, no GSB resistant genes have been identified in cucumber cultivars. In this study, the wild cucumber accession ‘PI 183967’ was used as a source of resistance to GSB in adult stems. An F2 population was mapped using resistant line ‘LM116’ and susceptible line ‘LM34’ derived from a cross between ‘PI 183967’ and ‘931’. By developing InDel and SNP markers, the gsb-s6.2 QTL on Chr. 6 was fine-mapped to a 34 kb interval harboring six genes. Gene Expression analysis after inoculation showed that two candidate genes (Csa6G046210 and Csa6G046240) were induced and differentially expressed between the resistant and susceptible parents, and may be involved in disease defense. Sequence alignment showed that Csa6G046210 encodes a Multiple myeloma tumor-associated protein, and it harbored two nonsynonymous SNPs and one InDel in the third and the fourth exons, and two InDels in the TATA-box of the basal promoter region. Csa6G046240 encodes a MYB transcription factor with six variants in the AP2/ERF and MYB motifs in the promoter. These two candidate genes lay the foundation for revealing the mechanism to GSB resistance, and may be useful for marker-assisted selection in cucumber disease-resistant breeding.
Successful creation of clinical AI without data scientists or software developers: radiologist-trained AI model for identifying suboptimal chest-radiographs
Authors: Dasegowda Giridhar , Bizzo Bernardo , Gupta Reya V. , Kaviani Parisa , Ebrahimian Shadi , Ricciardelli Debra , Abedi-Tari Faezeh , Neumark Nir , Digumarthy Subba R. , Kalra Mannudeep K. , Dreyer Keith J. 
Published: April 2022

Abstract
Objectives: Suboptimal chest radiographs(CXR) can limit interpretation of critical findings. Radiologist-trained AI models were evaluated for differentiating suboptimal(sCXR) and optimal(oCXR) chest radiographs.Methods: Our IRB-approved study included 3278 CXRs from adult patients (mean age 55 ± 20 years) identified from a retrospective search of CXR in radiology reports from 5 sites. A chest radiologist reviewed all CXRs for the cause of suboptimality. The de-identified CXRs were uploaded into an AI server application for training and testing 5 AI models. The training set consisted of 2202 CXRs(n= 807 oCXR; n= 1395 sCXR) while 1076 CXRs(n=729 sCXR; n=347 oCXR) were used for testing. Data were analyzed with the Area under the curve(AUC) for the model's ability to classify oCXR and sCXR correctly.Results: For the two-class classification into sCXR or oCXR from all sites, for CXR with missing anatomy, AI had sensitivity, specificity, accuracy, and AUC of 78%, 95%, 91%, 0.87(95% CI 0.82-0.92), respectively. AI identified obscured thoracic anatomy with 91% sensitivity, 97% specificity, 95% accuracy, and 0.94 AUC (95% CI 0.90-0.97). Inadequate exposure with 90% sensitivity, 93% specificity, 92% accuracy, and AUC of 0.91 (95% CI 0.88-0.95). The presence of low lung volume was identified with 96% sensitivity, 92% specificity, 93% accuracy, and 0.94 AUC(95% CI 0.92-0.96). The sensitivity, specificity, accuracy, and AUC of AI in identifying patient rotation were 92%, 96%, 95%, and 0.94 (95% CI 0.91-0.98), respectively.Conclusion: The radiologist-trained AI models can accurately classify optimal and suboptimal CXRs. Such AI models at the front end of radiographic equipment can enable radiographers to repeat sCXRs when necessary.
Influence of Personality and Concern for Health Information Privacy on PHR Adoption During COVID-19 Pandemic: An Empirical Investigation
Authors: Dutta Bireswar 
Published: April 2022

Abstract
The ongoing COVID-19 pandemic and changes imposed on the population enhanced the disparities among inhabitants' access to healthcare. Personal Health Record (PHR) allows individuals to access, manage, and share personal health-related information besides being active participants in personal care management. The study explores the relationship between personality traits and the threat of COVID-19 as antecedents of individuals' concern for health information privacy (CFHIP) and the subsequent relationship between individuals' CFHIP and behavioral intention to report their personal health information to healthcare providers concerning the use of PHR. This cross-sectional study employed a questionnaire to accumulate data from the individual in Taiwan. 265 valid responses were used for the final analysis. The research framework was evaluated by structural equation modeling (SEM) and represented by Smart-PLS and SPSS. The results suggested the proposed model explains about 64.2% of the variance of behavioral intention (R2 = 0.642). The findings supported that four personality traits: agreeableness, intellect, conscientiousness, neuroticism, and the threat of COVID-19 significantly influenced an individual's CFHIP. But concerning extraversion, an insignificant path coefficient was reported. Additionally, CFHIP mediates the relationship between threat of COVID-19 (PTD) and behavioral intention. Healthcare providers should consider these determinants in improving and endorsing principles concerning PHR adoption.
Influence of alkali-clay interactions on the shear strength and microstructure of alkaline-contaminated red clay
Authors: Wang Lianrui , Chen Jun , Wu Daoyong , Huang Yang , Wang Shuang 
Published: April 2022

Abstract
In recent years, the problem of soil contamination has become increasingly serious, which not only destroys the natural environment, but also may affect the stability of buildings because of the changes in the properties of contaminated soil. In this study, based on a practical alkaline-contaminated red clay engineering problem, the effects of alkaline-contamination on the mechanical properties and microstructure of red clay were investigated. The shear strength of alkaline-contaminated red clay obtained by unconsolidated undrained triaxial shear test (UU). The evolution of pore and particle characteristics of alkaline-contaminated red clay was analysed by mercury intrusion porosimetry (MIP), scanning electron microscope (SEM), X-ray diffraction (XRD), and thermal fractal dimension principle. The test results show that different concentrations of alkaline-contamination produce diverse new materials to change the microstructure of the clay; the variations in microstructure determine the changes in shear strength; the shear strength of alkaline-contaminated red clay decreases, then increases and then decreases with increasing the concentration, falling to a minimum at 3.5% concentration and rising to a maximum at 14% concentration; the internal mechanism of alkali-clay interactions can be divided into three processes: corrosion, cementation and dissolution; the changes in the engineering properties of alkaline-contaminated red clay are the result of the combined effect of these three processes. The results of this study can provide theoretical basis and reference value for the discussion of alkaline-contaminated soil engineering problems.
A radiomic nomogram based on CT images to predict survival outcomes in intrahepatic cholangiocarcinoma patients after resection
Authors: Wang Junli , He Mengye , Ni Jing , Zhang Xiaochen , Wei Yuguo , Sun Ke , Xiao Wenbo 
Published: April 2022

Abstract
Background: The purpose of this study was to establish a radiomics nomogram based on multiphase contrast-enhanced computed tomography (CT) to demonstrate the outcome of the patients after resection of intrahepatic cholangiocarcinoma (ICC).Methods: A cohort of 96 (7:3 in the training/validation cohort) ICC patients was enrolled in this study. All patients underwent a preoperative enhanced CT examination and then accepted the ICC resection. Radiomic features were extracted from arterial phase (AP) and portal venous phase (PVP) contrast-enhanced CT images. The least absolute shrinkage and selection operator (LASSO) Cox regression was used to select the features. Radiomic features and clinical data were combined to build the nomogram to predict the overall survival (OS). ICC patients were divided into high- and low- risk groups based on their probability of survival. The Kaplan–Meier analysis and the log-rank test were applied to analyze the patients, difference from different risk groups.Results: The C-index of the radiomics and clinical-nomogram for the prediction of OS in ICC patients was 0.869 and 0.632, 0.873 and 0.628 in the training and validation cohorts, respectively. The C-index of the combined nomogram for the prediction of OS in ICC patients was 0.912 and 0.696 in the training and validation cohorts, respectively. The calibration curve indicated that the predicted survival time was close to the actual survival time. Decision curve analysis showed that the combined nomogram has better clinical prediction than clinical or radiomics features alone. For ICC patients after surgical resection, the combined model showed that the low-risk group and high-risk group had a significant statistical difference in both the training cohort (p < 0.001) and the validation cohort (p = 0.01).Conclusion: Based on the application of preoperative enhanced CT radiomics in ICC, this study proposed a new personalized clinical decision nomogram, which can be used to predict the survival state of patients and play a certain role in assisting clinical treatment decision-making.
Can a failure in the error monitoring system explain unawareness of memory deficits in Alzheimer’s disease?
Authors: Razafimahatratra Solofo , Guieysse Thomas , Lejeune François-Xavier , Houot Marion , Medani Takfarinas , Dreyfus Gérard , Klarsfeld André , Villain Nicolas , Pereira Filipa Raposo , Corte Valentina La , George Nathalie , Pantazis Dimitrios , Andrade Katia 
Published: April 2022

Abstract

Unawareness of memory deficits is an early manifestation in patients with Alzheimer’s disease (AD). This intriguing behavior constitutes a form of anosognosia and has neural mechanisms that remain largely unknown. Here, we hypothesized that it may result from a failure in the error-monitoring system, which would prevent AD patients from being aware of their own memory impairment. To investigate, we measured event-related potentials (ERPs) evoked by erroneous responses during a memory task in two groups of amyloid positive individuals who had only subjective memory complaints at study entry: those who progressed to AD within the five-year study period (PROG group); and those who remained cognitively normal throughout the study (CTRL group). A significant reduction in the amplitude of the positivity error (Pe), an ERP related to error awareness, was observed in the PROG group at the time of AD diagnosis, in intra-group analysis, as well as when compared with the CTRL group, in inter-group analysis. To our knowledge, the results of this study reveal for the first time the emergence of a failure in the error-monitoring system from the very early stages of AD, strongly suggesting that a neurophysiological impairment in this system may be critical for the lack of awareness of memory deficits that often delays AD diagnosis. Hence, this study further suggests that a reduced Pe amplitude may constitute a potential neural biomarker of prodromal AD.
A Baseline Validation Study of the GALAD Model for Diagnosis of Hepatocellular Carcinoma Among Philippine Patients
Authors: Dating Mark Jay P. , Relente Marie Joy L. , Junio Dannah Zemirah G. , Tiangco Beatrice J. , Tripon Edhel S. , Albia Jason R. 
Published: April 2022

Abstract
Purpose
Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related death in the Philippines. Motivated by the lack of early-detection studies of HCC for Filipino cohorts, this study was designed to validate the GALAD model using a baseline dataset generated from a longitudinal study.
Methods
This study used 358 records collected from an ongoing study in the Philippines. The GALAD model was employed, and receiver operating characteristic (ROC) curve analyses were performed. The performance of the GALAD model and individual serum biomarkers in HCC detection were compared. Furthermore, the GALAD model was assessed in defined subgroups of patients.
Results
This study obtained an AUROC of 0.979 for the GALAD model with sensitivity and specificity ranging from 0.741 to 0.982. Its performance was also superior compared with the individual performance of AFP and DCP. Across the different subgroups, AUROCs were high, with the lowest being 0.821 on patients with cirrhosis.
Conclusion
This study found that the GALAD model was excellent for HCC detection in a Filipino cohort. It was also superior compared to AFP, AFP-L3, and DCP as individual tumor markers. Moreover, GALAD also exhibited remarkable performance in classifying HCC cases in all subgroups defined in the study.
Evaluation of Preoperative Fibrinogen/albumin Ratio and Carcinoembryonic Antigen: a New Prognostic Marker in Gastric Cancer
Authors: Hakseven Musluh , Çetindağ Özhan , Avşar Gökhan , Deryol Rıza , Sırgancı Gözde , Culcu Serdar , Akbulut Serkan , Ünal Ali Ekrem 
Published: April 2022

Abstract
Purpose Gastric cancer (GC) is one of the most common cancers that can result in death. Markers are needed to detect gastric cancer early and manage treatment. We aimed to reveal the relationship between carcinoembryonic antigen (CEA) level and Fibrinogen-Albumin ratio (FAR) and prognosis in gastric cancer, as well as to examine the relationship of these values with the number of metastatic lymph nodes and TNM stage.Methods The data of 805 consecutive gastrectomy patients were analyzed retrospectively. A total of 461 patients were included. The optimal cut-off values of CEA and FAR were 2.43 ng/mL and 1.26, respectively. Patients were stratified into three groups based on this cutoff value: CEA-FAR=0 (CEA <2.43 ng/mL and FAR <1.26), CEA-FAR=1 (CEA ≥2.43 ng/mL or FAR ≥1.26), and CEA-FAR=2 (CEA ≥2.43 ng/mL and FAR ≥1.26).Results There was a significant relationship between high CEA and stage (p=0.040), N status (p=0.017), and lymph node metastasis (p=0.004), and also there was a significant correlation between high FAR value and grade (p=0.003), stage (p<0.001), T status (p<0.001), N status (p<0.001) and metastatic lymph node count (p<0.001). Overall and disease-free survival were significantly different between the three CEA-FAR groupsConclusions We believe that pre-operative FAR and CEA values are independent predictors of survival. FAR and CEA are potential prognostic indicators for resectable gastric cancer due to their easy access and low cost. Considering survival and prognosis in patients with very high preoperative CEA and FAR values, neoadjuvant chemotherapy should also be considered.
Factors Associated with the Work-Self Balance of Nurses in an Advanced Medical Center
Authors: Okayasu Hiroaki , Sugawara Norio , Kawamata Yasushi , Yasui-Furukori Norio , Shimoda Kazutaka , Shinozaki Masataka , Tokumitsu Keita , Sato Yoshiteru , Sato Aoi , Uchibori Yumiko , Komatsu Tomie 
Published: April 2022

Abstract
Background
Maintaining a balance between one’s personal and working lives is important for nurses to increase their job satisfaction and continue their careers. Our purpose was to investigate the relationship of nurses’ characteristics, such as age, marital status and presence of cohabitating children, with work-self-balance (WSB) at different phases of life as well as the occupational factors that influence WSB that can be used to improve the work environment for nurses.
Methods
A cross-sectional survey of nurses was conducted from July to August 2020 using a self-administered questionnaire. We asked about gender, age, marital status, presence of children, working hours and night shift availability. The participants’ psychological distress was assessed with the Kessler 6, and occupational stresses, including WSB, were assessed with the New Brief Job Stress Questionnaire and the Organizational Justice Questionnaire. The total number of unmarried and married respondents was 819. We investigated whether marital status and presence of cohabitating children influenced WSB in three age groups (less than 30 years, from 31 to 40 years and more than 41 years) using a Mann–Whitney U test. In addition, we examined occupational factors affecting WSB using multiple regression analysis.
Results
The value of negative work-self balance was significantly greater in the group of married persons than in the group of unmarried persons (p < 0.05) and significantly greater in the group with cohabiting children than in the group without cohabiting children (P < 0.01) only in the group aged 31 to 40 years. Multiple regression analysis indicated that the significant occupational factors affecting WSB differed by age group.
Conclusions
This survey showed that the factors associated with WSB and the degree of WSB vary according to the generation and family environment of nurses.