bluuebunny/crossref_metadata_2025_split huggingface dataset:
MELATONIN CAN NOT SIGNIFICANTLY REDUCE BLOOD SUGAR LEVELS
Authors: Rinalda Christiana , Nugroho Taufik Eko , Batubara Lusiana , Budiastuti Asih 
Published: October 2022

AbstractBackground: Burn are trauma that can cause local and systemic damage including hypermetabolism, inflammation, and hyperglicemia. Stress Induced Hyperglycemia (SIH) occurs by increasing gluconeogenesis and insulin resistance. Both of these are mediated through an increase in regulated stress hormones and proinflammatory cytokines. Melatonin has been proposed as a burn supportive therapy that may prevent oxidative damage and inhibit excessive inflammatory responses.Aim: Proving the effects of melatonin supplementation on blood glucose level in male Wistar rats with burn injury.Methods: This research was an experimental with randomized control group pre-post test design. Twelve healthy male Wistar rats were included and divided into two groups, control and experimental group. Each rat was induced 30% burn injury under anesthesia. Rats in control group were given placebo, while rats in experimental group were treated with melatonin i.p at 0, 8 and 16 hours after burn injury. Blood samples were collected from the retroorbital sinuses at 0, 3, and 24 hours. Data were analyzed statistically by Paired t-Test and Independent t-Test. Results: In male Wistar rats with third degree burns given placebo, blood sugar levels significantly increase in 0-3 hours (p=0.006) and 0-24 hours (p=0.037). Meanwhile, in male Wistar rats with third degree burns given melatonin, blood sugar levels did not change significantly in 0-3 hours (p=0.470), 0-24 hours (p=0.286), dan 3-24 hours (p=0.833). Conclusions: Melatonin administration can not significantly reduce blood sugar levels.Keywords: Burn, burn injury, blood glucose level, melatonin.
FACTORS RELATED TO ECTOPIC PREGNANCY IN RSUD R.A KARTINI JEPARA
Authors: Pradana Muhammad Fikri Hanif Raza , Trisetiyono Yuli , Hariyana Bambang , Pramono Muhammad Besari Adi 
Published: October 2022

Background: Ectopic Pregnancy (EP) is a pregnancy outside the womb that ends with a rupture. Bleeding is one of the causes of the increase in Maternal Mortality Rate (MMR) by 24.5% in Central Java Province in 2017. Research to determine the factors associated with the occurrence of EP needs to be known so that the incidence of EP and MMR in Indonesia can be controlled.Purpose: This study aimed to see the incidence of EP and analyzing the relationship between age and parity with the incidence of EP in RSUD R.A Kartini Jepara.Methods: This study used an analytic observational method with a case-control research design. Sampling was done by consecutive sampling method. A total of 83 samples met the inclusion criteria, which were divided into 51 pregnant women with EP and 32 pregnant women without EP. Data were analyzed using descriptive test and Chi-square test. The factors assessed were age and parity. Other variables contained in medical records are included in the form of descriptive data.Results: The incidence of EP in RSUD R.A Kartini Jepara was 0.4% in 2017, 0.5% in 2018, and 0.3% in 2019. In EP patients, it was found that 54.9% of patients had an education level of junior high school, 58.8% of patients had a salpingectomy procedure, 92.1% of patients whose EP location was in the tube and 60.7% of patients needed inpatient services for >4 days. The results of the bivariate analysis using the Chi-square test showed a significant relationship between parity (p = 0.029) and the incidence of EP (p <0.05). Meanwhile, age (p = 0.897) did not show a significant relationship with the incidence of EP (p> 0.05).Conclusion: The incidence of EP in RSUD R.A Kartini Jepara in was 0.4% in 2017, 0.5% in 2018, and 0.3% in 2019. There is a relationship between parity and the incidence of EP. Meanwhile, age is not related to the incidence of EP in RSUD R.A Kartini Jepara. Keywords: Ectopic Pregnancy, Age, Parity
Baricitinib as Treatment Option for Corona Virus Disease-19: a Literature Review
Authors: Handoyo Thomas , Farhanah Nur , Pamungkas Gianina Dinda 
Published: October 2022

Background : Treatment of COVID-19 using IL-6 inhibitors, including Sarilumab or Tocilizumab, significantly decreased mortality risk. Though, Remdesivir therapy gave benefits, morbidity and mortality remained high. Baricitinib, a JAK inhibitor, can inhibit IL-6 activation pathway and has a potential effect of inhibiting disease progression to become severe.
Objective : This study aimed to evaluate the use of Baricitinib for COVID-19 patients.
Methods : This study was conducted by searching for observational and randomized controlled trial studies through online databases, “PubMed” and “Google Scholar”. Studies included must evaluate Baricitinib effectivity as therapy for hospitalized COVID-19 patients. This study included 11 studies (9 observational and 2 randomized controlled trial). Patients included had moderate-to-severe symptoms of COVID-19.
Results : Standard dose of Baricitinib was administered at 4 mg daily dose. Length of therapy was varied between 5-14 days, or up to patients’ discharge. Baricitinib therapy among included studies was administered with intravenous Remdesivir, Steroid, Tocilizumab, or other complement therapies. Mortality rate within 7-day of hospitalization with Baricitinib was 4.4%. Requirement of invasive mechanic ventilation rate after Baricitinib administration was approximately 4%. Laboratory parameters were significantly getting better after Baricitinib administration: IL-6; CRP; ferritin; and D-dimer. Serious adverse events in a randomized controlled trial, occurred more often in placebo treated compared to Baricitinib treated group.
Conclusion : Baricitinib as therapy for COVID-19 patients can decrease progression, morbidity, and mortality of the disease. Further studies are needed to evaluate the benefit of Baricitinib as main therapy for COVID-19.
COMPARISON OF ANTIBACTERIAL EFFECTIVENESS OF HERBAL TOOTHPASTE AND FLUORIDE ON THE GROWTH OF Streptococcus mutans
Authors: Dewanti Rosalia Indri , Ciptaningtyas V Rizke , Halleyantoro Ryan , Wibobo Gustantyo Wahyu 
Published: October 2022

Background: Streptococcus mutans was the most dominant bacteria in caused caries. Caries could be prevented by chemical plaque control methods used toothpaste. Toothpaste had antibacterial properties by helped to prevent bacteria from colonized. There were two antibacterial ingredients in toothpaste, fluoride and herbal ingredients.
Aim: Determined the antibacterial effect of toothpaste with herbal and fluoride content on the growth of Streptococcus mutans.
Methods: This study was an experimental study with a post-test only control group design. This research method was a diffusion method by means of wells. The sample used was the Streptococcus mutans colony. The study was divided into four groups, namely herbal toothpaste, fluoride toothpaste, positive control (chlorhexidine), and negative control (aquadest sterile) which were replicated 16 times in each group. The results of this study was the diameter of the resistance zone.
Results: The average diameter of the zone of inhibition results obtained 12.49 mm (herbal toothpaste), 14.66 mm (fluoride toothpaste), 21.70 mm (chlorhexidine) and aquadest sterile there were no inhibition zones. There was a significant difference with the p value
A Bibliometric Analysis of Nanocrystalline Cellulose Research as Medical Implant Using VOSviewer
Authors: Hafilah Deaniar , Nandiyanto Asep Bayu Dani 
Published: October 2022

Background: Nanocrystalline cellulose has potential for biomedical applications due to its abundant material availability, biodegradability, biocompatibility, and low weight. Research on nanocrystalline cellulose as medical implants has rarely been studied in the past 10 years, although this material has tremendous potential such as bone implants and cardiovascular implants.
Objective: This study aims to analyze the development of research on nanocrystalline cellulose as medical implants using a bibliometric approach with computational analysis using VOSviewer.
Methods: The article data was obtained using the Publish or Perish software by retrieving the database from Google Scholar. The keyword “nanocrystalline cellulose, medical implants, biomedical" is used with the publication time span from 2012 to 2020. Data processing uses Microsoft Excel. Computational mapping using VOSviewer.
Results: Research on the application of nanocrystalline cellulose has been carried out several times, this can be proven from computational mapping analysis using VOSviewer which shows the term "nanocrystalline cellulose" is in the same cluster as the term "medical implant". However, research on the application of nanocrystalline cellulose as medical implants is still rarely carried out, this is evidenced by the small frequency indicated by the two terms.
Conclusion: Based on the results of mapping the collected article data, research on the application of nanocrystalline cellulose as medical implants is an interesting topic. However, this topic is still rarely studied. Therefore, this review can be a starting point for selecting the topic of research on the application of nanocrystalline cellulose materials as medical implants as a consideration for determining the research theme to be taken.
KONDISI KUALITAS AIR DAN STRUKTUR KOMUNITAS DIATOM (BACILLARIOPHYCEAE) DI SUNGAI BABON
Authors: Rahman Arif , Haeruddin Haeruddin , Ghofar Abdul , Purwanti Frida 
Published: October 2022

Sungai Babon merupakan salah satu sungai di Semarang, Jawa Tengah yang dimanfaatkan untuk berbagai aktivitas manusia sehingga berpotensi menghasilkan limbah yang akan mencemari perairan. Perubahan kualitas air akibat pencemaran akan mempengaruhi persebaran dan struktur komunitas fitoplankton. Diatom (Bacillariophyceae) adalah salah satu kelompok fitoplankton yang tersebar luas di perairan karena memiliki daya adaptasi yang tinggi. Tujuan dari penelitian ini adalah mengetahui kondisi kualitas air dan struktur komunitas diatom (Bacillariophyceae) di Sungai Babon. Penelitian ini dilakukan di 5 stasiun yang tersebar dari hulu hingga hilir Sungai Babon pada bulan April dan Mei 2021. Variabel kualitas air yang diukur meliputi suhu, kecerahan perairan, pH, oksigen terlarut (DO), nitrat, dan fosfat. Hasil penelitian ini menunjukkan parameter kualitas air Sungai Babon masih sesuai dengan baku mutu PP RI No. 22 Tahun 2021 Kelas II tentang Penyelenggaraan Perlindungan dan Pengelolaan Lingkungan Hidup, kecuali kadar oksigen terlarut di Stasiun 5. Diatom (Bacillariophyceae) yang ditemukan di Sungai Babon berjumlah 17 genera. Diatom yang paling banyak ditemukan adalah Navicula, diikuti Synedra, Surirella, dan Melosira. Navicula adalah genus diatom yang ditemukan di semua stasiun penelitian dan memiliki kelimpahan tertinggi dengan persentase kelimpahan berkisar antara 13,82-52,83% dari kelimpahan total setiap stasiun. Diatom memiliki indeks keanekaragaman yang rendah, keseragaman tinggi (merata), dan dominansi rendah. Babon River is one of the rivers in Central Java that is used for various human activities so it has the potential to produce waste that will pollute the waters. Changes in water quality will affect the distribution and structure of the phytoplankton community. Diatoms (Bacillariophyceae) are a group of phytoplankton that is widely distributed in waters because they have high adaptability. The purpose of this study was to determine the condition of water quality and community structure of diatoms (Bacillariophyceae) in the Babon River. This research was conducted at 5 stations spread from upstream to downstream of the Babon River in April and May 2021. The water quality variables measured included temperature, water transparency, pH, dissolved oxygen, nitrate, and phosphate. The results showed that the water quality parameters of the Babon River are still following the quality standards of PP RI No. 22 of 2021 Class II, except for dissolved oxygen levels at Station 5. Diatoms (Bacillariophyceae) found in Babon River are 17 genera. The most common genus was Navicula, Synedra, Surirella, and Melosira. Navicula is a genus of phytoplankton found in all stations and has the highest abundance with a percentage from 13.82 to 52.83% of the total abundance of each station. Diatoms have a low diversity index, high similarity, and low dominance.
CLUSTERING CHARACTERISTICS OF SMALL-SCALE CAPTURE FISHERIES IN PRIGI, EAST JAVA
Authors: Sari Wahida Kartika , Harlyan Ledhyanne Ika , Fuad Fuad 
Published: October 2022

Small-scale capture fisheries condition is multi gear and multispecies has an impact on increasing the pressure of fish condition. The information related to fisheries resource status is very essential in order to build sustainable fisheries management planning. This study aims to analyze the level of fishing gear productivity, clustering of fishing gear based on the number of catch fish in Prigi, East Java. These study results are expected as sustainable small-scale fisheries management recommendations. This research methods were used the analyzed of diversity by Shannon-Wiener index, catch per unit effort (CPUE) and clustering of fishing gear based on a combination between principal component analysis (PCA) and hierarchical cluster. The results showed that the composition of the catch in each fishing gear was varied. The highest diversity of fish used gillnet as fishing gear. In general, the type of fishing gear with the most catches in AFP Prigi is handline, meanwhile scoop net became the highest CPUE of fishing. Clustering of fishing gear tends to be the same with varying proximity and gillnet fishing gear is a fishing gear that tends not to group with other tools. This study resulted that the clustering of fishing gear tends not to change in the last 10 years, however the correlation between groups are dynamic and this case has an impact on the variations of catch fish and fishing gear productivity.
ROTATING SAVINGS AND CREDIT ASSOCIATION (ARISAN): IMPACT STUDY ON HOUSEHOLD-LEVEL ANALYSIS
Authors: Astuti Riska Dwi 
Published: October 2022

Despite the fact that informal financial service is one of the most important alternative solutions for those in need yet do not have the capability to access the formal ones, its role is understudied. This study aims to analyze the impact of one of the informal financial services that have been developing within communities, rotating savings and credit association that is popular in term of arisan in Indonesia, on household economy measured by its spending on food and non-food. Using information from two latest data of Indonesian Family Life Survey processed with the difference in differences and matching methods, results show that household participation in the arisan is able to increase food and non-food expenditure after adjusted with inflation. Robustness checking through controlling several covariates shows consistent output sign and significances. It demonstrates that, statistically, arisan is able to improve its participant economic capabilities.
Faktor – Faktor yang Berpengaruh terhadap Deteksi Dini Kanker Leher Rahim Metode IVA di Kabupaten Banyumas (Studi di Puskesmas Cilongok I)
Authors: Izah Yuni Nurul , Octaviana Devi , Nurlaela Sri 
Published: October 2022

Background: Cases of cervical cancer in Banyumas Regency have increased over the last four years but the coverage of early detection of VIA is still very low. The purpose of this study was to determinant factors of early detection of cervical cancer using visual inspection with acetic acid (VIA) method in Banyumas Regency (Study at Puskesmas Cilongok I).Methods: The research used cross-sectional design in 2021 with population of 13.679 women of childbearing. A sample of 93 women used purposive sampling technique. The research variables are knowledge, attitude, education, economic level, age, parity, access to health facilities, access to information, family support and support for health workers. The research instrument used google form. The data analysis performed was univariate analysis, bivariate analysis using chi square, and multivariate analysis using logistic regression.Result: Most of the respondents did not perform early detection of cervical cancer using VIA method (62.4%). The results of the analysis showed that there was a relationship between knowledge, attitudes, education, and family support (p-value= 0.027; 0.031; 0.025; 0.039) with early detection of cervical cancer using VIA method. Determinant factors of early detection of cervical cancer using VIA were are knowledge, attitudes, education, and family support (POR=3.984; 7.273; 0.187; 3.863).Conclusion : Attitude is the most determining factor in early detection of cervical cancer using the VIA method. Women should increase their positive attitude in supporting early detection of cervical cancer.
Faktor-Faktor Keterlambatan Diagnosis Kanker Pada Pasien Kanker Payudara : Systematic Review
Authors: Shidqi Zahrah Nabila , Saraswati Lintang Dian , Kusariana Nissa , Sutiningsih Dwi , Udiyono Ari 
Published: October 2022

Background: Breast cancer is one of the most common cancers and has a high mortality rate in women. Patient-mediated factors and healthcare provider-mediated factors are factors associated with cancer delay. This study aims to identify the factors associated with breast cancer delay.Methods: A systematic review was carried out using the PRISMA without meta-analysis method on articles published in 2012-2021. Article searches were conducted using the ScienceDirect, PubMed, EBSCOhost, and Google Scholar databases.Result: From a total of 256 articles that are relevant to the article search keywords, four articles are eligible for this review.Conclusion : Factors related to patient delay are the level of education. Factors related to system delays and diagnosis delays are the place of residence.
Pengaruh Kualitas Produk Dan E-Wom Terhadap Keputusan Pembelian Portobello Semarang
Authors: Amarazka Vega , Dewi Reni Shinta 
Published: October 2022

Abstract: The arrival of technology made a huge jump in all industries, including in the Food & Beverage sector. Food is a primary need for human existence to be fullfilled. Therefore, the growth in this sector is always rising because of the new touch that often leads to innovation especially in kinds of variety of food. Portobello is a local restaurant that offers western foods with pasta and pizza specialty and also local foods located in Semarang Indonesia. Based on the sales report, from 2015 until 2019 the company was facing fluctuated sales. From the researcher perspective, product quality and e-WOM could be the cause of the fluctuated sales. This study aims to determine the influence of product quality and e-WOM on purchase decision of Portobello, Sumurboto consumer. The type of research is explanatory research and using non-probability sampling techniques, purposive sampling and accidental sampling. The samples used for this research are 100 respondents that just visited the restaurant. This research uses statistic system SPSS version 20 and qualitative and quantitative analysis with validity, reliability, correlation coefficients, coefficient of determination, simple and multiple regression, the significance of t-test and F test.Keywords: Product Quality; E-WOM; Purchase Decisions Abstrak: Kehadiran teknologi membuat lompatan yang besar dalam semua industri, termasuk salah satunya di bidang Food & Beverage. Makanan adalah kebutuhan primer manusia yang harus dipenuhi. Maka itu, perkembangan di sektor ini terus meningkat karena ragamnya inovasi produk makanan yang selalu dilakukan oleh pelaku bisnis. Portobello adalah restoran lokal yang menawarkan menu western seperti pasta, pizza dan lainnya serta makanan lokal yang berlokasi di Semarang, Indonesia. Berdasarkan data penjualan yang didapat, dari tahun 2015 sampai 2019 Portobello mengalami pendapatan yang fluktuatif. Maka dari itu, kualitas produk dan e-wom dapat diduga menjadi faktor penyebab fluktuasi tersebut.Penelitian ini bertujuan untuk mengetahui pengaruh kualitas produk dan e-wom terhadap keputusan pembelian pada konsumen Portobello, Sumurboto. Tipe penelitian adalah eksplanatory research dan pengambilan sampel menggunakan teknik non probability sampling, purposive sampling dan accidental sampling. Pengumpulan data menggunakan kuesioner dan google form. Sampel yang digunakan sebanyak 100 responden konsumen Portobello, Sumurboto Kota Semarang. Penelitian ini menggunakan sistem statistik SPSS versi 20 dan menggunakan analisis kuantitatif dengan uji validitas, reliabilitas, koefisien korelasi, koefisien determinasi, regresi sederhana dan berganda, signifikansi uji t dan uji F.Kata Kunci: Kualitas Produk; E-WOM; Keputusan Pembelian
Pengaruh Product Quality dan Service Quality terhadap Brand Switching Melalui Customer Value (Studi pada Mantan Pelanggan Indihome di Kota Semarang)
Authors: Widyaningrum Hapsari Wahyu , Farida Naili , Prihatini Apriatni Endang 
Published: October 2022

This study aims to determine the effect of product quality and service quality on brand switching through customer value” (study of former IndiHome customers in Semarang). This type of research is explanatory research. The sampling method in this research is non-probability sampling by purposive sampling. The data collection process uses Google forms with 100 respondents from former IndiHome customers in Semarang City as the research sample. The analysis used is regression analysis and path analysis. The results of the research show that product quality has an effect on customer value, service quality has an effect on customer value, product quality has a negative effect on brand switching, service quality has no effect on brand switching, and customer value has no effect on brand switching. The results of the path analysis show that there is an indirect effect between product quality on brand switching through customer value, so that customer value partially mediates between product quality and brand switching. in addition, there is a direct influence between service quality on brand switching through customer value, so that customer value cannot partially mediate between service quality and brand switching. Suggestions that can be given to IndiHome include updating core products and innovations in features, increasing customer awareness regarding the My IndiHome application and conducting training for officers, providing discounts or promos at certain times and actively contacting customers regularly to ensure whether there are complaints. and what problems the customer is experiencing.
5. INOVASI MANAJEMEN PEMERINTAHAN DAERAH DALAM PENANGGULANGAN KEMISKINAN DI KOTA PEKALONGAN
Authors: Kushandajani Kushandajani 
Published: October 2022

This research is motivated by the deepen concern toward the fenomena of poverty in Indonesia, in otherhand application of decentralization is exist for a while. So, it’s important thing to study how to make poverty reduction with innovation programes in decentralization era. Result this research describes that the capasity of Walikota to puss four social institutions: Badan Keswadayaan Masyarakat (BKM), Lembaga Pemberdayaan Masyarakat (LPM), Pendidikan Kesejahteraan Keluarga (PKK), and Karang Taruna can solve the poverty problems in Kota Pekalongan. There are many innovation programes in Kota Pekalongan, where All programes are community based: Replication of Program Penangggulangan Kemiskinan Perkotaan (P2KP), Program Percepatan Pembangunan Keluarga Sejahtera Berbasis Masyarakat (P2KSBM), Program Daerah Pemberdayaan Masyarakat (PDPM), and Replication of Pembangunan Lingkungan Permukiman Berbasis Komunitas (PLPBK) that focused in neighborhood develompent.By means of strengtening capacityof social institution at Kelurahan also integrated planning and budgeting, innovation programs can be done succesfully.