bluuebunny/crossref_metadata_2025_split huggingface dataset:
Eco-friendly Green Composites Reinforced with Recycled Polyethylene for Engineering Applications
Authors: Azeko Salifu Tahiru , Mensah Jacob Kofi , Arthur Emmanuel Kwesi , Abiwu Napoleon , Flomo Moses Kingsford , Boadu Joseph Asiamah , Yamba Philip , Larson Enoch Asuako , Akayeti Anthony , Satankar Raf Kumar , Annan Ebenezer 
Published: December 2022

Abstract
Polyethylene (PE) and cement are serious industrial wastes that promote environmental pollution, with these pollutants having tremendous effects on the lives of humanity and other living creatures, including animals. Therefore, this research presents the results of experimental and theoretical modeling of green composites (without the inclusion of cement) reinforced with recycled polyethylene waste for applications in the Mechanical and Civil Engineering industry. The composites are produced using different weight percentages of laterite and molten PE mixed homogeneously to produce unique green composites with excellent mechanical properties. The green composite with 40 wt.% laterite and 60 wt.% PE exhibited the highest compressive strength, flexural strength and fracture toughness of 25 MPa, 7.3 MPa and , respectively. Additionally, the green composite recorded maximum yield stress of . The maximum yield stress of the green composites falls under the minimum range of yield stress for traditional concrete structures. The SEM images reveal evidence of bonding and ligament bridging in the green composites reinforced with 40 wt.% laterite and 60 wt.% PE. The probability distribution plots show that the polyethylene in the green composites follows the Weibull distribution with low Anderson Darling Statics and p-values greater than the significance level of 5%.
Experience of Chinese Countermarching Nurses with COVID-19 Patients' Death in Wuhan: A Qualitative Study
Authors: GUO Zhifang , Wu Kunli , Shan Huibin , kim Younglee , He Qilian 
Published: December 2022

Abstract
Background: The COVID-19 pandemic was occurring worldwide with over a 6.5million deaths. It’s important to explore the instructions for the global nursing community by identifying the personal coping methods of Chinese nurses in Wuhan to deal with patient deaths.
Methodology: A qualitative phenomenological study was designed to describe 14 Chinese nurses' COVID-19 patient death experiences through in-depth interviews in April 2022, data were analyzed by conventional content analysis methods.
Results: Four themes and subthemes were generated in which participants reported their contacts with COVID-19 patients’ death. The main themes were psychological shock, psychological adjustment, and demands, insights into life and values, and the need for relevant knowledge and skills.
Conclusions: The study provided evidence of nurses‘ psychological and professional needs regarding patient deaths during the epidemic. The instructions integrated from nurses' stories could give guidance for a well-prepared global nursing workforce and high-quality end-of-life patient care in the present and future epidemics.
Igloo-technique for robotic radical prostatectomy—maximum nerve sparing for very early recovery of continence and sexual function
Authors: Fankhauser Christian Daniel , Malkmus Christian , Aschwanden Fabian Joel , Baumeister Philipp , Mattei Agostino 
Published: December 2022

Abstract
Background: We describe a surgical technique to facilitate very early return of continence and erectile function after robotic-assisted radical prostatectomy (RARP) for prostate cancer.
Objective: To describe the “igloo technique” for RARP.
Design, setting, and participants: Prospective study of the first 13 patients to be treated with the igloo technique at a major urban hospital. Only patients without suspected invasion of the neurovascular bundle were included.
Surgical procedure: RARP was performed using “igloo technique” to preserve all periprostatic structures, including the puboprostatic ligament complex, neurovascular bundles, Santorini complex, endopelvic and periprostatic fascia, and accessory pudendal arteries.
Outcome measurements and statistical analysis: Descriptive analysis of the perioperative, pathological, and short-term oncological outcomes.
Results and limitations: The median operative time was 200 minutes [inter-quartile range (IQR): 188–210]. The transurethral catheter was removed after a median of 3 days post-RARP. In the first 24 hours after catheter removal, the median urine loss was 4g/24h[IQR: 2–10g/24h]. Ten days after surgery, 3 patients had urine loss of 10g/24h, and 10 patients had urine loss of 0g/24h. At 6 weeks after surgery, only 1 patient had urine loss of 10g/24h, and the remaining 12 patients all reported urine loss of 0g/24h. The median IIEF-15 decrease after surgery was 19[IQR: 5–36]. Positive surgical margins were reported for 4 participants(31%), and biochemical recurrence was observed in 1 subject who did not have a positive surgical margin.
Conclusions: The igloo technique is a technically demanding technique for RARP that spares most periprostatic structures with very early return of continence and erectile function after surgery. Despite case selection, a considerable proportion of participants showed a positive surgical margin.
Patient summary: Through improved preservation of the anatomical structures around the prostate, we achieved very early return of urinary continence and erectile function after surgical removal of the prostate.
Construction and validation of a necroptosis-related gene signature associated with the tumor microenvironment in melanoma
Authors: Huang Jie , Lao Jianle , Lai Hongyi , Tan Zhen , Qin Wentao 
Published: December 2022

Abstract
Background
Although carcinogenesis, cancer metastasis, and immunology are all closely related to necroptosis, research is still insufficient to pinpoint the precise function of necroptosis-related genes (NPRGs) in melanoma.
Methods
The training cohort included melanoma patient samples from The Cancer Genome Atlas (TCGA), and the validation cohort included melanoma patient samples from the Gene Expression Omnibus (GEO) database (GSE65904). The least absolute shrinkage and selection operator (LASSO) regression was used in the training cohort to construct prognostic signatures based on six NPRGs. Patients were split into groups with high and low risk. The Kaplan-Meier method compared the various risk groups' overall survival (OS). Utilizing Cox regression, the effect of their clinicopathological characteristics and risk scores on survival was assessed. The CIBERSORT method was used to evaluate the immunological microenvironment. The relationship between clinical features, levels of checkpoint gene expression, and risk scores were examined using correlation analysis. The GEPIA2 database and immunohistochemistry were used to confirm the gene expression of six NPRGs (IHC).
Results
The prognostic signature of the NPRGs predicted a worse OS in the high-risk group, and the test cohort corroborated this prediction. In patients with melanoma, risk scores also independently predicted survival outcomes. Significant differences existed between the various risk groups in the immune microenvironment and the expression of checkpoint genes. Necroptosis score revealed a substantial positive link with natural killer cells and M2 macrophages and a significant negative correlation with T-cell and B-cell infiltration. In the high-risk group, several immune checkpoint genes displayed low levels of expression. The results of the IHC investigation were in agreement with the expression of NPRGs from GEPIA2.
Conclusion
In melanoma patients, the prognostic signature linked to NPRGs can be employed as novel prognostic predictors of prognosis and the immune microenvironment.
Probabilistic and deterministic based approach for Liquefaction potential assessment of layered soil
Authors: Poddar Prince , Ojha Sauhadra , Gupta Mohit Kumar 
Published: December 2022

Abstract
The assessment of liquefaction potential in the present study is based on deterministic and probabilistic approach. The deterministic approach was used to analyze the liquefaction assessment of loose saturated river bed deposit with emphasis to two benchmark location. A wide range earthquake data in form of PGA’s value of 0.18g, 0.37g, 0.6g, 0.75g is used as input motion. The dynamic properties of soil were evaluated by using SPT data obtained from the bore log locations. The shear stress induced within soil deposit due to the seismic excitation in the form of cyclic stress ratio (CSR) and cyclic resistance ratio (CRR) was calculated in order to calculate the factor of safety (FOS) against liquefaction. In addition to that, liquefaction potential index (LPI) and probability of liquefaction was also calculated using input motion. It was observed that the shallow layer soil profile is safe against liquefaction whereas deep layer soil profile is unsafe based on probability of liquefaction index.
Geochemical, sedimentological and microbial diversity in contrasting thermokarst lake sediments of Far Eastern Siberia
Authors: Meisel Ove Hanns , Rijkers Ruud , Dean Joshua F. , Zandt Michiel H. in 't , Huissteden Jacobus van , Maximov Trofim C. , Karsanaev Sergey V. , Marchesini Luca Belelli , Goovaerts Arne , Wacker Lukas , Reichart Gert-Jan , Bouillon Steven , Welte Cornelia U. , Jetten Mike S. M. , Vonk Jorien E. , Dolman Han 
Published: December 2022

Abstract
Thermokarst lakes are important conduits for organic carbon (OC) sequestration, soil organic matter (SOM) processing and atmospheric greenhouse gas (GHG) release in the Arctic. They can be classified as either floating-ice lakes, which sustain a zone of unfrozen sediment (talik) at the lakebed year-round, or as bedfast-ice lakes, which freeze all the way to the lakebed in winter. This difference in winter ice regime, as well as their eroding shorelines which mainly determine the quantity and quality of organic matter (OM) input into the lakes, is thought to have a strong influence on the lake’s sediment characteristics and general lake biogeochemistry. We used an array of physical, geochemical, and microbiological tools to identify the differences in the environmental conditions, sedimentary characteristics, carbon stocks and microbial community compositions in the sediments of a bedfast-ice and a floating-ice lake in Far East Siberia with different eroding shorelines. Our data show strong differences across most of the measured parameters between the two lakes. For example, the floating-ice lake contains considerably lower amounts of SOM and dissolved organic carbon (DOC), both of which also appear to be more degraded in comparison to the bedfast-ice lake, based on their stable carbon isotope composition (δ13C). We also document clear differences in the microbial community composition, for both archaea and bacteria. We identified two main drivers of the sedimentary, microbial and biogeochemical diversity in thermokarst lakes. First, the lake depth, which defines the ice regime (bedfast-ice and floating-ice) and thereby also determines the absence or presence of taliks. Second, the input of eroded shoreline soils and OM into the lakes from different allochthonous sources. With ongoing climate warming, it is likely that an increasing number of lakes will shift from a bedfast- to a floating-ice state, and that increasing levels of shoreline erosion will supply the lakes with sediments. Yet, still little is known about the physical, biogeochemical and microbial differences in the sediments of these lake types and how different eroding shorelines impact these lake systems.
Treatment of Persistent Idiopathic Facial Pain with High Cervical Spinal Cord Stimulation: Case Report
Authors: Potru Sudheer , Singh Vinita 
Published: December 2022

Abstract
Introduction:
Facial pain presents complex clinical challenges for the treating clinician, whether those arise from 1) a diagnostic standpoint with identifying the source of pain; 2) dealing with medication side effects at higher doses; or 3) issues with identifying small anatomical structures for interventional or surgical treatment. Atypical facial pain, now known as persistent idiopathic facial pain (PIFP), is no exception to these rules, and is often more refractory than other types of facial pain to conventional treatment options.
Neuromodulation (including both spinal cord and peripheral nerve stimulation) has been described to treat some types of facial pain, with the best evidence available thus far for trigeminal neuralgia, but there is limited evidence thus far for PIFP.
Case Presentation:
We review here the case of a 70-year-old man with significant PIFP versus trigeminal neuralgia, refractory to medications and other interventions. He had excellent relief of his pain with high cervical spinal cord stimulation, and we address the diagnostic challenges related to the true source of pain (equivocal results from interventional procedures) as well as the numerous failed treatment modalities in his care.
Conclusions:
High cervical and cervicomedullary spinal cord stimulation has potential to treat persistent facial pain other than that related to trigeminal neuralgia, and we hope to see more literature for these challenging facial pain states moving forward.
Metabolic crosstalk between skeletal muscle and liver through IRF4-FSTL1 in NASH
Authors: Guo Shangshan , FENG YONGHAO , ZHU XIAOPENG , Zhang Xinyi , Gao Huanqing , Wang Hui , Wang Ruwen , Zhang Qiongyue , Li Yiming , Ren Yan , Gao Xin , Bian Hua , Liu Tieming , Kong Xingxing 
Published: December 2022

Abstract
Inter-organ crosstalk has gained more and more attention recently. However, the mechanisms under this remain incompletely understood. Here, we revealed an endocrine pathway regulated by skeletal muscle IRF4 that manipulates liver pathology. Skeletal muscle specific IRF4 knockout (F4MKO) mice showed ameliorated liver steatosis, inflammation, and fibrosis, without changes in body weight on nonalcoholic steatohepatitis (NASH) diet. Proteomics analysis of serum suggested that follistatin-like protein 1 (FSTL1) might link the communication between muscle and liver. Dual luciferase assays showed that IRF4 could transcriptionally regulate FSTL1 and reconstitution of FSTL1 expression in muscle of F4MKO mice was sufficient to restore the liver pathology. Furthermore, co-culture experiments verified that different receptors contribute to FSTL1’s function in different cell types of liver. Finally, we found serum FSTL1 level was positively correlated with NASH progression in human. These data unveiled a signaling pathway from skeletal muscle to liver via IRF4-FSTL1-DIP2A/CD14 in the pathogenesis of NASH.
Comparison of porcine early colonization tendency of intestinal flora between Lantang and Landrace newborn piglets
Authors: li ling , Li Shuai , Luo Junyi , Chen Ting , Xi Qianyun , Zhang Yongliang , Sun Jiajie 
Published: December 2022

Abstract
Background: The early colonization and succession of intestinal microbiota plays a fundamental role in host health and development. To investigate the difference of porcine early colonization tendency of intestinal flora between Lantang and Landrace, we amplified and sequenced the V3-V4 region of 16S rRNA gene in jejunal microbiota of Lantang and landrace piglets.
Results: The findings revealed that the dominant phyla in the jejunum of Lantang piglets were Firmicutes, Actinobacteria and Bacteroidetes, while the dominant phyla of Landrace is Proteobacteria and Fusobacteria. Specifically, Corynebacterium_1, Lactobacillus, Rothia, Granulicatella, Corynebacteriales_unclassified, Corynebacterium, Globicatella and Actinomycetales_unclassified were found to be the dominant genera of Lantang group, while Clostridium_sensu_stricto_1, Escherichia-Shigella, Actinobacillus and Bifidobacterium were the dominant genera of Landrace. Based on the functional prediction of bacteria, we found that bacterial communities from Lantang samples had a significantly greater abundance pathways of fatty acid synthesis, protein synthesis, DNA replication, recombination, repair and material transport across membranes, while the carrier protein of pathogenic bacteria was more abundant in Landrace samples.
Conclusions: Overall, there was a tremendous difference in the early colonization of intestinal microbiota between the two pig species, which may be related to the growth characteristics. However, more further extensive studies should be included to reveal the underlying relationship between early intestinal microbiota colonization in different breeds and pig growth characteristics.
Study on Gas Concentration Prediction of Tunnel Engineering Based on UMAP-BiLSTM
Authors: ZHANG Lunning , RONG Ming , HE Wei , ZHU Keying , ZHAO Qing 
Published: December 2022

Abstract
A deep learning model for Unified Manifold Approximation Projection (UMAP) and Bidirectional Long and Short Time Memory (BiLSTM) is proposed to predict that air ambient gas concentration of the tunnel face in the tunnel and provide early warning to protect the life safety of workers. Firstly, UMAP model reduces the dimensionality of high-dimensional data measured by sensors, and then uses BiLSTM model to predict low-dimensional time series data. Thanks to its long-term dependence capture ability, the characteristics of historical data can be learned in a better way to predict the gas concentration in the closed area of tunnels. In this paper, the proposed model is used to predict the concentration of five gases (O2, CO, CL2, CH4 and H2S) in Kuitun River Tunnel Project in Xinjiang. Compared with three machine learning models: Support Vector Machine (SVM), Autoregressive Integrated Moving Average (ARIMA) and BP neural network, the results show that the prediction performance based on UMAP-BiLSTM model is the best, and its Mean Absolute Error (MAE), Mean Absolute Percentage Error (MAPE) and Root Mean Square Error (RMSE) are 0.868, 3.925 and 1.5196 respectively. Compared with the existing SVM, ARIMA and BP neural network models, UMAP-BiLSTM model is the best in the comparison models in five kinds of gas concentration prediction, which shows that it puts forward a prediction model with higher efficiency in this paper.
Rational and semi-rational solutions to the Davey-Stewartson III equation
Authors: Wang Shengnan , Yu Guo-Fu 
Published: December 2022

Abstract
In this paper, based on the combination of Hirota’s bilinear method and long wave limit technique, we investigate rational and semi-rational solutions to the third-type Davey-Stewartson (DS III) equation and its nonlocal version. Rational solutions to the DS III equation demonstrate to be kinks, lumps and line rogue waves, while semi-rational solutions display hybrids of solitons, lumps and line rogue waves. As to the nonlocal DS III equation, we derive (semi-)rational solutions and breather solutions. Semi-rational solutions show lumps on the periodic line backgrounds, hybrids of breathers and lumps, line rogue waves and line breathers on the periodic line background.
Preoperative nomogram based on CT imaging to predict recurrence of early-stage glottic cancer after larynx-preserving surgery
Authors: Zhang Huanlei , Pan Mingzhi , Zhu Xuelin , Zhao Xiuli , Feng Qiang 
Published: December 2022

Abstract
Background
The aim of this research is to explore the difference in clinicopathologic and CT features of early-stage glottic cancer (EGC) with or without recurrence after larynx-preserving surgery (LPS), and to establish a preoperative nomogram for predicting postoperative recurrence.
Methods
The clinicopathologic and CT features of 98 consecutive patients with EGC were analyzed retrospectively. Independent predictors for recurrence were determined by multivariate logistic regression analysis and presented with a nomogram. A Harrell’s concordance index (C-index) and a calibration plot were used to assess the performance of the nomogram. The clinical net benefit of the model was evaluated using decision curve analysis (DCA).
Results
There were significant differences in T stage, depth, and normalized CT value (NCT) in arterial phase (NCTAP) and NCT in the venous phase (NCTVP) between with and without recurrence group (all P < 0.05). T stage, depth, and NCTVP were independent predictors of recurrence (Odds ratio [OR] 3.27, 95% confidence interval [CI] 1.70–7.27, P = 0.016; OR 5.02, 95% CI 1.65–14.08, P = 0.005, and OR 3.60, 95% CI 2.55–9.63, P = 0.017, respectively). The C-index showed that the nomogram (0.790, 95%CI: 0.675–0.904) has good prediction performance and better than T stage (C-index, 0.619, 95%CI: 0.508–0.730). The calibration curve showed that the predicted probabilities of the nomogram were in good agreement with the actual probabilities, and DCA indicated that it provided more net benefit than the treat-none or treat-all scheme.
Conclusions
CT could provide independent recurrence indicators in patients with EGC, and the developed nomogram may be a potential noninvasive tool to guide personalized treatment.
Comparison of long-term effects of metformin on longevity between people with Type 2 diabetes and matched non-diabetic controls
Authors: Stevenson-Hoare Joshua , Leonenko Ganna , Escott-Price Valentina 
Published: December 2022

Abstract
Background

Metformin, a medication for type 2 diabetes, has been linked to many non-diabetes health benefits including increasing healthy lifespan. Previous work has only examined the benefits of metformin over periods of less than ten years, which may not be long enough to capture the true effect of this medication on longevity.

Methods

We searched medical records for Wales, UK, using the Secure Anonymised Information Linkage dataset for type 2 diabetes patients treated with metformin (N = 129,140) and sulphonylurea (N = 68,563). Non-diabetic controls were matched on sex, age, smoking, and history of cancer and cardiovascular disease. Survival analysis was performed to examine survival time after first treatment, using a range of simulated study periods.

Findings

Using the full twenty-year period, we found that type 2 diabetes patients treated with metformin had shorter survival time than matched controls, as did sulphonylurea patients. Metformin patients had better survival than sulphonylurea patients, controlling for age. Within the first three years, metformin therapy showed a benefit over matched controls, but this reversed after five years of treatment.

Interpretation

While metformin does confer benefits to longevity in the short term, these initial benefits are outweighed by the effects of type 2 diabetes when patients are observed over a period of up to twenty years. Longer study periods are therefore recommended for studying longevity and healthy lifespan.
Long-COVID symptom risk among COVID-19 patients and its relationship to COVID-19 vaccination; a prospective cohort study
Authors: Hamdah Bayan Abu , Nazzal Zaher 
Published: December 2022

Abstract
The acute COVID-19 presentation is well described in the literature, but the long-term effect is unclear. This study aims to find the incidence of long-COVID symptoms and the associated risk factors among COVID-19 patients. A prospective cohort study in Palestine included 669 confirmed COVID-19 patients. Sociodemographic and clinical data were extracted from their medical records and collected via semi-structured telephone interviews on Days 10, 30, 60, and 90 using a semi-structured questionnaire. The incidence of long-COVID symptoms was 41.6% (95%CI: 37.8–45.4%). Females [aOR = 1.5 (95%CI:1.1–2.3)], the elderly [aOR = 4.9 (95%CI:2.0-11.3)], and those who required hospitalization [aOR = 5.0 (95%CI:1.3–3.7)] were at a higher risk of developing long-COVID symptoms, as well as patients with dyspnea at day ten [aOR:2.4 (95%CI: 1.6–3.7] and fatigue at day 60 [aOR:3.1 (95%CI:1.5–6.3]. On the other hand, vaccination was found to be protective; non-vaccinated patients were almost seven times more likely than vaccinated patients to report long symptoms [aOR:6.9 (95%CI:4.2–11.3)]. In conclusion, long-COVID symptoms are common among COVID-19 patients, with higher rates among females, older age groups, hospitalized patients, and those with dyspnea and fatigue, while vaccination has proven effective. Therefore, it is essential to identify at-risk patients early and provide appropriate management.