bluuebunny/crossref_metadata_2025_split huggingface dataset:
The 6 degrees-of-freedom range of motion of the L1–S1 vertebrae in young and middle-aged asymptomatic people
Authors: Xu Fei , Zhou Siyu , Li Zhuofu , Jiang Shuai , Chen Ze , Sun Zhuoran , Li Weishi 
Published: October 2022

Study designControlled laboratory study.ObjectiveTo determine the 6 degrees of freedom of lumbar vertebra in vivo during different functional activities in young and middle-aged asymptomatic subjects.MethodsA total of 26 asymptomatic subjects (M/F, 15/11; age, 20–55 years) were recruited in this study. They were divided into two groups: young group (number: 14; age: 20–30 years old) and middle-aged group (number: 12; age: 45–55 years old). The lumbar segment of each subject was scanned by computed tomography for the construction of three-dimensional (3D) models of the vertebra from L1 to S1. The lumbar spine was imaged by using a dual fluoroscopic system when the subjects performed different trunk postures. The 3D models of vertebrae were matched to two fluoroscopic images simultaneously in software. The range of motion (ROM) of vertebrae in the young and middle-aged groups was compared by using multiway analysis of variance, respectively.ResultsDuring the supine to the upright posture, vertebral rotation of the L1–S1 occurred mainly around the mediolateral axis (mean: 3.9 ± 2.9°). Along the mediolateral axis, vertebral translation was significantly lower at L1–2 (7.7 ± 2.4 mm) and L2–3 (8.0 ± 3.5 mm) than at L3–4 (1.6 ± 1.2 mm), L4–5 (3.3 ± 2.6 mm), and L5–S1 (2.6 ± 1.9 mm). At the L4–5 level, the young group had a higher rotational ROM than the middle-aged group around all three axes during left–right bending. Along the anteroposterior axis, the young group had a lower translational ROM at L4–5 than the middle-aged group during left–right bending (4.6 ± 3.3 vs. 7.6 ± 4.8 mm; P &lt; 0.05). At L5–S1, the young group had a lower translational ROM than the middle-aged group during flexion–extension, left–right bending, and left–right torsion.ConclusionThis study explored the lumbar vertebral ROM at L1–S1 during different functional postures in both young and middle-aged volunteers. There were higher coupled translations at L3–4 and L4–5 than at the upper lumbar segments during supine to upright. The vertebral rotation decreased with age. In addition, the older subjects had a higher anteroposterior translation at the L4–5 segment and higher mediolateral translation at the L5–S1 segment than the young group. These data might provide basic data to be compared with spinal pathology.
Dynamic risk prediction models for different subtypes of hypertensive disorders in pregnancy
Authors: Zhang Xinyu , Xu Qi , Yang Lin , Sun Ge , Liu Guoli , Lian Cuiting , Li Ziwei , Hao Dongmei , Yang Yimin , Li Xuwen 
Published: October 2022

BackgroundHypertensive disorders in pregnancy (HDP) are diseases that coexist with pregnancy and hypertension. The pathogenesis of this disease is complex, and different physiological and pathological states can develop different subtypes of HDP.ObjectiveTo investigate the predictive effects of different variable selection and modeling methods on four HDP subtypes: gestational hypertension, early-onset preeclampsia, late-onset preeclampsia, and chronic hypertension complicated with preeclampsia.MethodsThis research was a retrospective study of pregnant women who attended antenatal care and labored at Beijing Maternity Hospital, Beijing Haidian District Maternal and Child Health Hospital, and Peking University People's Hospital. We extracted maternal demographic data and clinical characteristics for risk factor analysis and included gestational week as a parameter in this study. Finally, we developed a dynamic prediction model for HDP subtypes by nonlinear regression, support vector machine, stepwise regression, and Lasso regression methods.ResultsThe AUCs of the Lasso regression dynamic prediction model for each subtype were 0.910, 0.962, 0.859, and 0.955, respectively. The AUC of the Lasso regression dynamic prediction model was higher than those of the other three prediction models. The accuracy of the Lasso regression dynamic prediction model was above 85%, and the highest was close to 92%. For the four subgroups, the Lasso regression dynamic prediction model had the best comprehensive performance in clinical application. The placental growth factor was tested significant (P &lt; 0.05) only in the stepwise regression dynamic prediction model for early-onset preeclampsia.ConclusionThe Lasso regression dynamic prediction model could accurately predict the risk of four HDP subtypes, which provided the appropriate guidance and basis for targeted prevention of adverse outcomes and improved clinical care.
Prognostic value of final pathological stage in colon adenocarcinoma after neoadjuvant chemotherapy: A propensity score-matched study
Authors: Xiang Meijuan , Liang Zongyu , Gao Yuan , Feng Xingyu , Yao Xueqing 
Published: October 2022

BackgroundNeoadjuvant chemotherapy (NAC) could improve local tumor control of locally advanced colon cancer (LACC), but the prognostic value of yp stage in colon cancer remains unknown. Here, we aimed to ascertain yp stage as an indicator for LACC prognosis after NAC.MethodsThe data of patients diagnosed with colon adenocarcinoma between 2004 and 2015 were extracted from the Surveillance, Epidemiology, and End Results database. After 1:2 propensity score matching, cancer-specific survival (CSS) and overall survival (OS) were compared between the NAC and Non-NAC groups of different stage classifications. The correlation between clinical and pathological factors and CSS was identified.ResultsA total of 49, 149, and 81 matched pairs of stage 0–I, II, and III patients, respectively, were generated for analysis. For stage 0–I (p = 0.011) and III (p = 0.015), only CSS in the NAC groups were inferior. Receiving NAC was an independent prognostic risk factor for patients with stage 0–I (hazard ratio, 7.70; 95% confidence interval, 1.820–32.5; p = 0.006) and stage III (hazard ratio, 1.73; 95% confidence interval, 1.11–2.68; p = 0.015).ConclusionsThe CSS was poorer among LACC patients who underwent NAC than among those who did not. The yp stage of colon cancer after NAC has distinctive significance, which may contribute to predicting the prognosis and guiding the treatment of LACC patients after NAC.
Development of reference intervals for pupillometry in healthy dogs
Authors: Mills Erinn P. , Combs-Ramey Kelli , Kwong Grace P. S. , Pang Daniel S. J. 
Published: October 2022

BackgroundPupillometry, the measurement of pupil size and reactivity to a stimulus, has various uses in both human and veterinary medicine. These reflect autonomic tone, with the potential to assess nociception and emotion. Infrared pupillometry reduces inaccuracies that may occur when the pupillary light reflex is determined subjectively by the examiner. To our knowledge, there are no published studies outlining normal reference intervals for automated pupillometry in dogs.ObjectiveThe objective of this study was to developde novoautomated pupillometry reference intervals from 126 healthy canine eyes.MethodsThe pupillary light reflex (PLR) was measured with a handheld pupillometer (NeurOptics™ PLR-200™ Pupillometer). Parameters recorded included maximum pupil diameter (MAX), minimum pupil diameter (MIN), percent constriction (CON), latency (LAT), average constriction velocity (ACV), maximum constriction velocity (MCV), average dilation velocity (ADV) and time to 75% pupil diameter recovery (T75). One measurement was obtained for each eye.ResultsThe following reference intervals were developed: MAX (6.05–11.30 mm), MIN (3.76–9.44 mm), CON (−37.89 to −9.64 %), LAT (0.11–0.30 s), ACV (−6.39 to −2.63 mm/ s), MCV (−8.45 to −3.75 mm/s), ADV (−0.21–1.77 mm/s), and T75 (0.49–3.20 s).Clinical significanceThe reference intervals developed in this study are an essential first step to facilitate future research exploring pupillometry as a pain assessment method in dogs.
Morphological, Pathological and Genetic Diversity of the Colletotrichum Species, Pathogenic on Solanaceous Vegetable Crops in Bulgaria
Authors: Manova Vasilissa , Stoyanova Zornitsa , Rodeva Rossitza , Boycheva Irina , Korpelainen Helena , Vesterinen Eero , Wirta Helena , Bonchev Georgi 
Published: October 2022

Colletotrichum species are among the most devastating plant pathogens in a wide range of hosts. Their accurate identification requires a polyphasic approach, including geographical, ecological, morphological, and genetic data. Solanaceous crops are of significant economic importance for Bulgarian agriculture. Colletotrichum-associated diseases pose a serious threat to the yield and quality of production but are still largely unexplored. The aim of this study was to identify and characterize 26 pathogenic Colletotrichum isolates that threaten solanaceous crops based on morphological, pathogenic, and molecular data. DNA barcodes enabled the discrimination of three main taxonomic groups: C. acutatum, C. gloeosporioides, and C. coccodes. Three different species of acutatum complex (C. nymphaeae, C. godetiae, and C. salicis) and C. cigarro of the gloeosporioides complex were associated with fruit anthracnose in peppers and tomatoes. The C. coccodes group was divided in two clades: C. nigrum, isolated predominantly from fruits, and C. coccodes, isolated mainly from roots. Only C. salicis and C. cigarro produced sexual morphs. The species C. godetiae, C. salicis, and C. cigarro have not previously been reported in Bulgaria. Our results enrich the knowledge of the biodiversity and specific features of Colletotrichum species, which are pathogenic to solanaceous hosts, and may serve as a scientific platform for efficient disease control and resistance breeding.
Mechanical, Physical, and Chemical Properties of Mycelium-Based Composites Produced from Various Lignocellulosic Residues and Fungal Species
Authors: Aiduang Worawoot , Kumla Jaturong , Srinuanpan Sirasit , Thamjaree Wandee , Lumyong Saisamorn , Suwannarach Nakarin 
Published: October 2022

Mycelium-based composites (MBCs) are characterized as biodegradable materials derived from fungal species. These composites can be employed across a range of industrial applications that involve the manufacturing of packaging materials as well as the manufacturing of buildings, furniture, and various other household items. However, different fungal species and substrates can directly affect the functional properties of MBCs, which ultimately vary their potential to be used in many applications. In this study, the mechanical, physical, and chemical properties of MBCs made from four different fungal species (Ganoderma fornicatum, Ganoderma williamsianum, Lentinus sajor-caju, and Schizophyllum commune) combined with three different types of lignocellulosic residues (sawdust, corn husk, and rice straw) were investigated. The results indicate that differences in both the type of lignocellulosic residues and the fungal species could affect the properties of the obtained MBCs. It was found that the MBCs obtained from sawdust had the highest degree of density. Moreover, MBCs obtained from S. commune with all three types of lignocellulosic residues exhibited the highest shrinkage value. The greatest degree of water absorption was observed in the MBCs obtained from rice straw, followed by those obtained from corn husk and sawdust. Additionally, the thermal degradation ability of the MBCs was observed to be within a range of 200 to 325 °C, which was in accordance with the thermal degradation ability of each type of lignocellulosic residue. The greatest degrees of compressive, flexural, impact, and tensile strength were observed in the MBCs of G. williamsianum and L. sajor-caju. The results indicate that the MBCs made from corn husk, combined with each fungal species, exhibited the highest values of flexural, impact, and tensile strength. Subsequently, an analysis of the chemical properties indicated that the pH value, nitrogen content, and organic matter content of the obtained MBCs were within the following ranges: 4.67–6.12, 1.05–1.37%, and 70.40–86.28%, respectively. The highest degree of electrical conductivity was observed in MBCs obtained from rice straw. Most of the physical and mechanical properties of the obtained MBCs were similar to those of polyimide and polystyrene foam. Therefore, these composites could be used to further develop relevant strategies that may allow manufacturers to effectively replace polyimide and polystyrene foams in the future.
Optical Measurement of Molar Absorption Coefficient of HbA1c: Comparison of Theoretical and Experimental Results
Authors: Hossain Shifat , Satter Shama , Kwon Tae-Ho , Kim Ki-Doo 
Published: October 2022

Diabetes can cause dangerous complications if not diagnosed in a timely manner. The World Health Organization accepts glycated hemoglobin (HbA1c) as a measure of diagnosing diabetes as it provides significantly more information on the glycemic behavior from a single blood sample than the fasting blood sugar reading. The molar absorption coefficient of HbA1c is needed to quantify the amount of HbA1c present in a blood sample. In this study, we measured the molar absorption coefficient of HbA1c in the range of 450 nm to 700 nm using optical methods experimentally. We observed that the characteristic peaks of the molar absorption coefficient of HbA1c (at 545 nm and 579 nm for level 1, at 544 nm and 577 nm for level 2) are in close agreement with those reported in previous studies. The molar absorption coefficient values were also found to be close to those of earlier reports. The average molar absorption coefficient values of HbA1c were found to be 804,403.5 M−1cm−1 at 545 nm and 703,704.5 M−1cm−1 at 579 nm for level 1 as well as 503,352.4 M−1cm−1 at 544 nm and 476,344.6 M−1cm−1 at 577 nm for level 2. Our experiments focused on calculating the molar absorption coefficients of HbA1c in the visible wavelength region, and the proposed experimental method has an advantage of being able to easily obtain the molar absorption coefficient at any wavelength in the visible wavelength region. The results of this study are expected to help future investigations on noninvasive methods of estimating HbA1c levels.
An Insight of the Theoretical Physics of Ru-Alloyed Iron Pyrite Studied for Energy Generation
Authors: Nofal Muaffaq M. , Sai Refka , Shawish Ihab , Alaqeel Muneerah A. 
Published: October 2022

Pyrite FeS2 has become the focus of many researchers in thin-film photovoltaics because it has some possibilities in photovoltaics. In this manuscript, we present an experimental and a theoretical study of the electronic structure of pyrite FeS2 alloyed with a small concentration of 1.19% of ruthenium (Fe0.9881Ru0.0119S2) by using the Linear Muffin-Tin Orbital Method in the Atomic-Sphere approximation (LMTO-ASA) calculations and the density of states. We observed that the bandgap of FeS2 increases from 0.90508 to 1.21586 eV when we replace ~1.19% of the Fe atoms with ruthenium atoms x=0.0119 concentration of Ru. We prove that this low concentration of Ru saved the gap states and the electronic and optical properties of FeS2 pyrite. Our calculated electronic bandgap is 1.21586 eV and direct. Our results confirm that the symmetric operation of the space Th6 Pa3 saves electronic structure of iron pyrite when alloyed with ruthenium.
Analysis of Human Papilloma Virus Content and Integration in Mucoepidermoid Carcinoma
Authors: Gu Wenjin , Bhangale Apurva , Heft Neal Molly E. , Smith Josh D. , Brummel Collin , McHugh Jonathan B. , Spector Matthew E. , Mills Ryan E. , Brenner J. Chad 
Published: October 2022

Mucoepidermoid Carcinomas (MEC) represent the most common malignancies of salivary glands. Approximately 50% of all MEC cases are known to harbor CRTC1/3-MAML2 gene fusions, but the additional molecular drivers remain largely uncharacterized. Here, we sought to resolve controversy around the role of human papillomavirus (HPV) as a potential driver of mucoepidermoid carcinoma. Bioinformatics analysis was performed on 48 MEC transcriptomes. Subsequent targeted capture DNA sequencing was used to annotate HPV content and integration status in the host genome. HPV of any type was only identified in 1/48 (2%) of the MEC transcriptomes analyzed. Importantly, the one HPV16+ tumor expressed high levels of p16, had high expression of HPV16 oncogenes E6 and E7, and displayed a complex integration pattern that included breakpoints into 13 host genes including PIK3AP1, HIPI, OLFM4,SIRT1, ARAP2, TMEM161B-AS1, and EPS15L1 as well as 9 non-genic regions. In this cohort, HPV is a rare driver of MEC but may have a substantial etiologic role in cases that harbor the virus. Genetic mechanisms of host genome integration are similar to those observed in other head and neck cancers.
A THEORETICAL MODEL OF EMPATHIC INTERACTION BETWEEN A PSYCHOLOGIST AND A CLIENT: A CYCLICAL-ACTION APPROACH
Authors: Furman A. 
Published: October 2022

The interdisciplinary study is devoted to the elucidation of the author's concept of the deed integral, developmentally enriched and dialogically directed empathic interaction of a psychologist with clients of different ages, gender, mental experience, social status and mental organization of the individual self. The proposed concept was created, on the one hand, through a reflexive reconstruction of the content of the psychological theory of empathy known in Ukraine and abroad (L.P. Zhuravlyova, 2007), when it is step-by-step achieved, scenario-worked out and practically realized, mutual complementation of the developmental functioning of various types, levels and stages of the empathic process, resources, channels and means of empathic attitudes-relationships and individual psychological features of empathy of each participant in dialogic contact in the "psychologist-client" system, on the other hand - due to the use of the latest methodological optics of post-non-classical rationality, namely the author's cyclical-action approach with its basic principles (cyclicity, synergy, action, metasystem), a number of regularities and norms of cognitive thinking activity. Moreover, the universal tool for implementing research consciousness into life, which establishes the epistemological core of the concept advocated here, is a m e n t a l s c h e m e built according to the principle of quaternity in the context of the broad intellectual possibilities of the innovative sphere of professional methodologization (A.V. Furman, 2005, 2016). The starting idea in this case was the axiomatic statement that the process cycle of the current course of empathy is a separate, original act on the part of the individual. Taking into account the goal, task and subject field of this study, it is proved that: firstly, the most effective technology of collaborative psycho-spiritual filling of interpersonal relationships is modular-developmental interaction, which is first subject to a reflexive-action scripting, and then to a full-fledged existential implementation; secondly, the stages of deployment of personified empathic interaction can not only be justified on the basis of dominant processes (affective, cognitive, conative), but also more methodologically justified on the basis of the logic-canonical structure of the act (situation, motivation, action, afteraction); thirdly, the empathic dialogic cycle is best consciously organized by a practical psychologist while working with a client as a four-periodized and step-by-step (procedural) detailed act of personal empathy, which includes the alternating dominance of natural, affective-cognitive, conative-active and reflective types of empathy; fourthly, the psychologist's practical use of the action-reflective thinking scheme of the scenario confirmed the empirical effectiveness in his individual work with students of secondary and higher education, in particular with those who have special needs or are characterized by problematic behavior.
Avanços e desafios da comunicação digital em saúde na era da pandemia
Authors: Abreu Natasha Ribas de Figueiredo Ortiz , Carvalho André Luís Bonifácio de 
Published: October 2022

Introdução: a pandemia do COVID-19 provocou mudanças importantes no uso das tecnologias e da comunicação digital. É necessário compreendermos melhor as práticas de enfrentamento da pandemia pela população através da apropriação de informações veiculadas pelas mídias sociais. Espera-se que este trabalho auxilie na formulação de estratégias de educação em saúde na ESF. O objetivo deste artigo é identificar o uso e as possibilidades de comunicação digital em saúde no contexto da pandemia. Método: trata-se de uma revisão integrativa norteada pela pergunta: “Como tem se dado o uso da comunicação digital em saúde diante do contexto da pandemia do COVID-19? ”. A busca bibliográfica foi realizada nas bases SCOPUS, Scielo e BVS, utilizando os descritores: Comunicação em saúde, Disseminação da informação e COVID-19. Resultados: foram selecionados 16 artigos que, depois de análise dos estudos de Bardin, suscitaram três categorias: A potencialidade na divulgação e no acesso à informação; Plataformas digitais e suas dimensões; e Fake News e Infodemia - os transtornos diante da desinformação digital. Conclusões: o impacto das informações em saúde produzidos nas mídias digitais durante a pandemia aponta para uma transformação nos processos de educação em saúde e de relacionamento com a informação na era digital.
saúde do trabalhador na Atenção Primária à Saúde: vivências em uma Unidade Básica de Saúde em Belo Horizonte, Minas Gerais
Authors: Souza Neto Fábio  de , Bezerra Olívia Maria de Paula Alves 
Published: October 2022

O presente estudo teve como foco a atual relação entre a Saúde do Trabalhador (ST) e a Atenção Primária à Saúde (APS) no contexto da Unidade Básica de Saúde (UBS) Confisco, situada na cidade de Belo Horizonte, Minas Gerais. A relevância da pesquisa está no fato de ainda haver lacunas a ser preenchidas em termos das ações em ST no âmbito dos cuidados primários em saúde, conforme definido pela Política Nacional de Saúde do Trabalhador e da Trabalhadora (PNSTT), de 2012. O objetivo principal foi desvelar a interação entre APS e a ST, evidenciando a importância dessa relação, os avanços e, principalmente, os desafios ainda existentes no desenvolvimento das políticas de proteção à saúde do trabalhador. As informações que sustentam esse estudo foram obtidas em pesquisa transversal qualitativa, cuja metodologia incluiu uma roda de pesquisa on-line com profissionais da UBS e de entrevistas semiestruturadas com os profissionais do Centro de Referência em Saúde do Trabalhador (CEREST) e com usuários da UBS. Qualificar, então, a assistência aos trabalhadores no Sistema Único de Saúde (SUS) foi a principal proposta do estudo.