bluuebunny/crossref_metadata_2025_split huggingface dataset:
Do terms of trade affect economic growth? Robust evidence from India
Authors: Singh Tarlok 
Published: September 2022

AbstractThis study extends the previous empirics and conducts a comprehensive analysis of the effects of terms of trade (TOT) on economic growth in the large and emerging market economy, India, which experienced tremendous transformation from a persistently low‐growth economy in the 1950s–1970s to a moderate‐growth economy in the 1980s and then to a high‐growth economy, following the onset of inclusive economic reforms from the beginning 1990s. The TOT remained unfavourable during the 1950s, witnessed boom during the mid‐1960s to the mid‐1970s, showed sharp downturn during the mid‐1970s to the mid‐1980s, and then displayed deteriorations again from the late 1990s to 2017–2018. The model estimated in one‐regime setting with no structural break and in a sample‐split setting with multiple structural breaks—over both “long” and “short” time periods—supports the presence of cointegration among variables and suggests the positive and significant long‐run effects of TOT on economic growth. The diversification of trade, the continual improvements in the quality of export products, and the development of high value‐added industries are essentially crucial to induce long‐term improvements in TOT. The improvements in TOT need to be accompanied by the development of financial sector, expansion of external trade, and acceleration of domestic investment.
Adult female exposure to mild ultraviolet radiation reduces longevity but not egg load in two parasitoid wasps
Authors: Gaudreau Mathilde , Brodeur Jacques , Abram Paul K. 
Published: September 2022

AbstractInsects can be exposed to ultraviolet (UV) radiation throughout their lifecycle when they rest, forage, and mate. The negative effects that such highly energetic photons can have on insect fitness are not well‐known, especially for natural exposure during the adult stage. Adult insects are considered to be more resistant to UV radiation than their immature stages, but this assumption is supported by only a few studies on a restricted set of pest species. We conducted the first investigation of the vulnerability of parasitoid adults to UV exposure, by assessing the longevity and potential fecundity of female Telenomus podisi Ashmead and Trissolcus utahensis Ashmead (Hymenoptera: Scelionidae) receiving low doses of UV‐A and visible radiation daily in the laboratory. Parasitoids died up to 2× faster with increasing levels of UV radiation, and, to a lesser extent, of visible radiation. There was no effect of UV radiation on maximum egg load resulting from oogenesis in early adulthood. This study on beneficial insects indicates that the physiological consequences of cumulative exposure to even mild doses of more energetic optical radiation, particularly in the UV range, should not be underestimated in natural and managed ecosystems.
5′‐nucleotidase, cytosolic II genotype, and clinical outcome in patients with acute myeloid leukemia with intermediate‐risk cytogenetics
Authors: Díaz‐Santa Johana , Rodríguez‐Romanos Rocío , Coll Rosa , Osca Gemma , Pratcorona Marta , González‐Bártulos Marta , Garrido Ana , Angona Anna , Talarn Carme , Tormo Mar , Arnan Montserrat , Vives Susanna , Salamero Olga , Tuset Esperanza , Lloveras Natàlia , Díez Isabel , Zamora Lurdes , Bargay Joan , Sampol Antonia , Cruz David , Vila Jordi , Sitges Marta , Garcia Antoni , Vall‐Llovera Ferran , Esteve Jordi , Sierra Jorge , Gallardo David ,   the “Grupo Cooperativo Para el Estudio y Tratamiento de las Leucemias Agudas y Mielodisplasias” (CETLAM group)
Published: September 2022

AbstractAcute myeloid leukemia (AML) is a complex disease, and its treatment needs to be adjusted to the risk, which is conferred by cytogenetics and molecular markers. Cytarabine is the main drug to treat AML, and it has been suggested that the genotype of cytarabine metabolizing enzymes may have a prognostic relevance in AML. Here we report the association between the 5′‐nucleotidase, cytosolic II (NT5C2) rs10883841, cytidine deaminase (CDA) rs2072671 and rs532545 genotypes and the clinical outcome of 477 intermediate‐risk cytogenetic AML patients receiving cytarabine‐based chemotherapy. Patients younger than 50 years old with the NT5C2 rs10883841 AA genotype had lower overall survival (OS) (p: .003; HR 2.16, 95% CI 1.29–3.61) and lower disease‐free survival (DFS) (p: .002; HR 2.45, 95% CI 1.41–4.27), associated to a higher relapse incidence (p: .010; HR 2.23, 95% CI 1.21–4.12). Interestingly, subgroup analysis showed that the negative effect of the NT5C2 rs10883841 AA genotype was detected in all subgroups except in patients with nucleophosmin mutation without high ratio FLT‐3 internal tandem duplication. CDA polymorphisms were associated with the complete remission rate after induction chemotherapy, without influencing OS. Further studies are warranted to determine whether this pharmacogenomic approach may be helpful to individualize AML treatment.
Present status and future directions: Imaging techniques for the detection of periapical lesions
Authors: Cotti Elisabetta , Schirru Elia 
Published: September 2022

AbstractDiagnosing and treating apical periodontitis (AP) in an attempt to preserve the natural dentition, and to prevent the direct and indirect systemic effects of this condition, is the major goal in endodontics. Considering that AP is frequently asymptomatic, and is most often associated with a lesion in the periapex of the affected tooth, within the maxillary bones, imaging becomes of paramount importance for the diagnosis of the disease. The aim of this narrative review was to investigate the most relevant classic and current literature to describe which are, to date, the diagnostic imaging systems most reliable and advanced to achieve the early and predictable detection of AP, the best measures of the lesions and the disclosure of the different features of the disease. Dental panoramic tomography (DPT) is a classic exam, considered still useful to provide the basic diagnosis of AP in certain districts of the maxillary bones. Periapical radiographs (PRs) represent a valid routine examination, with few, known limitations. Cone‐beam computed tomography (CBCT) is the only system that ensures the early and predictable detection of all periapical lesions in the jaws, with the minor risk of false positives. These techniques can be successfully implemented, with ultrasounds (USI) or magnetic resonance (MRI) imaging, exams that do not use ionising radiations. MRI and USI provide information on specific features of the lesions, like the presence and amount of vascular supply, their content and their relationship with the surrounding soft tissues, leading to differential diagnoses. Further, all the three‐dimensional systems (CBCT, USI and MRI) allow the volumetric assessment of AP. Pioneering research on artificial intelligence is slowly progressing in the detection of periapical radiolucencies on DPTs, PRs and CBCTs, however, with promising results. Finally, it is established that all imaging techniques have to be associated with a thorough clinical examination and a good degree of calibration of the operator.
What does luxury really mean to millennial consumers?
Authors: Slaton Kelcie , Hurst Jessica L. 
Published: September 2022

AbstractThe aim of this study was to determine how millennial luxury consumers define luxury based on a holistic systems theory perspective. The human ecosystem and its components were used to fully investigate the system of the millennial luxury consumer. A mixed methodology was used by conducting interviews and then a consumer survey. Based on the findings from this research, the definition for luxury based on the view of the millennial luxury consumer is as followed: Luxury is the characteristics of the product themselves, addresses the consumer's personal needs, and addresses the consumer's social needs. This study suggests that the ecosystem of the millennial luxury consumers, including its environments and interactions, helped in constructing their definition of luxury. This definition delivers millennial luxury consumer insights for luxury retailers and may provide strategic adaptations to help attract and retain millennial luxury consumers, while also supporting business sustainability in a challenging retail environment.
Chemical characterisation and in vitro wound healing activity of Tunisian ghee products
Authors: Maiza Afraa , Ghazouani Tesnime , Nzekoue Franks Kamgang , Caprioli Giovanni , Fiorini Dennis , Vittori Sauro , Francucci Beatrice , Marucci Gabriella , Buccioni Michela , Fattouch Sami 
Published: September 2022

SummaryAyurvedic literature has demonstrated the healing properties of ghee when used systemically and topically. Ghee possesses regenerative properties that can heal wounds, and therefore, the study aimed to compare different types of Tunisian ghee (traditional and industrial cow, goat and sheep) for their wound healing activity. Comparison of the ghee was achieved by studying their antioxidant activity, oxidative stability, fatty acids and vitamin composition analysis, as well as their ability to stimulate dermal fibroblast migration and wound healing process. This study indicates that this Tunisian product with high antioxidant capacity rich in vitamins A and E could improve fibroblast migration, suggesting thus an application as a healing element in an ointment base.
The effects of full‐stream and partial high‐pressure homogenisation on the properties of milk emulsion
Authors: Kiełczewska Katarzyna , Brożek Oskar , Rudkowska Paulina , Garczewska‐Murzyn Anna , Smoczyński Michał 
Published: September 2022

SummaryThe study evaluated the effects of full‐stream and partial high‐pressure homogenisation (HPH) on the properties of milk with 3.5% fat content. During full‐stream HPH, the size of particles decreased with an increase in temperature. Fat globules were smaller in milk treated by full‐stream than partial HPH at 60°C. Creaming was not observed in milk subjected to full‐stream HPH. In milk treated by partial HPH, the phase separation rate during ≤48 h of storage increased in samples processed at 60°C, 40°C and 20°C. Despite high top layer volume in milk that was HPH‐treated at a temperature of ≥40°C, its fat content was lower than in milk homogenised at 20°C. The total difference in colour was approximately 1.5–2.0‐fold higher in full‐stream homogenised milk. Partial HPH can be applied in dairy products requiring milk fat dispersion with minimal changes in the components of the colloidal and soluble phases.
Degradation of curcumin‐mediated photodynamic technology (PDT) on polycyclic aromatic hydrocarbons in oysters and toxicity evaluation of PDT‐treated oysters
Authors: Zhi Jinjin , Tang Qingjuan , Wu Shuangjie , Kong Biao , Jiang Jiali , Li Zhaojie , Wang Yuming , Xue Changhu 
Published: September 2022

SummaryThis study investigated the degradation effect of curcumin‐mediated photodynamic technology (PDT) on polycyclic aromatic hydrocarbons (PAHs) in oysters, and evaluated the safety of PDT‐treated oysters through acute and subacute toxicity experiments. The results demonstrated that curcumin‐mediated PDT could effectively degrade multi‐component PAHs in oysters, the maximum removal efficiency could reach 80.20% (10 μmol L−1 curcumin concentration and 54 J cm−2 light energy density). Acute toxicity experiment revealed PDT‐treated oysters did not cause any mortality and adverse symptoms in mice at an oral dose of 40 g kg−1 BW. Besides, after being treated at the dose of 10 g kg−1 BW for 28 days, the rats showed no obvious abnormal change in the indicators including the body weight, food utilisation, urology, haematology, serum biochemistry, organ index and histopathology. These findings show curcumin‐mediated PDT is a potentially efficacious method to degrade PAHs in oysters, and PDT‐treated oysters have high edible safety.
Identification of the key structure, preparation conditions and properties of resistant dextrin for indigestibility based on simulated gastrointestinal conditions
Authors: Li Zerun , Liu Yang , Huang Yanhong , Tian Yanjun , Liu Jianjun , Wang Shanshan , Sun Ping , Nie Yupeng , Gan Shaobo , Xu Hui 
Published: September 2022

SummaryResistant dextrin has broad application prospects as a functional dietary fibre. However, the structural mechanism underlying indigestibility has not yet been reported. The structures and properties of three types of resistant dextrins before and after simulated digestion were characterised. The results showed that the new glycosidic linkages and α‐1,6 linkages dense distribution region were the main causes of resistance to digestive enzymes. Moreover, after the ordered crystal structure was damaged, new glycosidic linkages and 1,6‐anhydro‐β‐d‐glucopyranose were concentrated on the short side chain, which was not conducive to the formation of double‐helix structure, and the degree of branching (DB) increased. Thus, DB increased and negatively correlated with the degree of polymerisation and the average chain length. After adding transglycosidase, the dietary fibre content was higher than 70% and DB increased to 48.87%, indicating the strongest resistance to digestive enzymes. This study provides important information to produce resistant dextrin of higher indigestibility.
Frequency of skin cancer and evaluation of risk factors: A hospital‐based study from Turkey
Authors: Ferhatosmanoğlu Arzu , Selcuk Leyla Baykal , Arıca Deniz Aksu , Ersöz Şafak , Yaylı Savaş 
Published: September 2022

AbstractObjectivesSkin cancers are the most common type of cancer with a significantly increasing incidence. The purpose of the study was to uncover the one‐year frequency of melanoma and non‐melanoma skin cancers (NMSC) and to determine the risk factors in the development of skin cancer.MethodsThe study included 7396 people from all age groups admitted to the dermatology clinic between October 2020 and 2021. The sociodemographic characteristics, sun protection habits, chronic diseases, and drug and vitamin use were evaluated. Lesions with clinical suspicion of skin cancer were excised.ResultsThe frequency of skin cancer was found to be 2.7%, basal cell cancer (BCC) 1.2%, squamous cell cancer (SCC) 1.1%, malignant melanoma (MM) was 0.4%. Daily black tea consumption was found to be a risk factor for three type of skin cancer, BCC (p = 0.021), SCC (p = 0.006), and MM (p = 0.002), respectively. Obesity was observed as a risk factor for BCC (p = 0.005) and MM (p = 0.008). We found that having a history of alcohol use were an independent risk factor for all skin cancer types and BMI <30 for SCC. Vitamin D and supplemental drugs intake were observed as protective factors for BCC (p = 0.035, p = 0.007, respectively). Daily coffee consumption was determined as a protective factor for SCC (p < 0.001) and MM (p = 0.049).ConclusionThis study estimates the frequency of NMSC and melanoma. Also provides evidence to determine the risk factors and probably protective factors for the development of skin cancers.
Periodontal status is associated with oral function in community‐dwelling older adults, independent of dentition status
Authors: Ueno Yui , Iwasaki Masanori , Kimura Yumi , Kakuta Satoko , Masaki Chihiro , Wada Taizo , Sakamoto Ryota , Ishimoto Yasuko , Fujisawa Michiko , Okumiya Kiyohito , Ansai Toshihiro , Matsubayashi Kozo , Hosokawa Ryuji 
Published: September 2022

AbstractObjectiveTo determine whether periodontal status is associated with oral function, including masticatory performance and occlusal force, among community‐dwelling older adults.BackgroundAlthough a potential association between periodontal status and oral function has been reported, variations in the root surface area (RSA) of each tooth have not been considered.MethodsWe used data from a population‐based study involving community‐dwelling older adults. The RSA with periodontal ligament (RSA–PL), which quantifies the RSA attached to the periodontal ligament and alveolar bone, was calculated based on full‐mouth periodontal examination. Masticatory performance was assessed using spectrophotometric measurement of the color (a* value) of color‐changing chewing gum. The bilateral maximal occlusal force (MOF) was measured using a pressure‐sensitive sheet and dedicated software. The associations of the RSA–PL, a quantitative marker of periodontal tissue support, with the a* value and MOF were assessed using linear regression models.ResultsThe analyses included data from 250 adults [60.8% women; age, mean (standard deviation) 82.5 (5.0) years]. On average, the study participants had an RSA–PL of 26.3 cm2, a* value of 25.0, and an MOF value of 555.1 N. After adjustments for potential confounders, including dentition status, age, sex, dental visit regularity, smoking status, physical activity level, depressive symptoms, a history of stroke or diabetes mellitus, and body mass index, the RSA–PL was found to be associated with the a* value [coefficient (per 1 cm2 increase): 0.16, 95% confidence interval (CI) 0.10–0.22)] and MOF (coefficient: 9.2, 95% CI 5.3–13.1).ConclusionThis study demonstrated that greater amounts of remaining tooth‐supporting structures, indicated by higher RSA–PL values, were associated with better masticatory performance and a higher occlusal force among community‐dwelling older adults.
HCV hotline facilitates Hepatitis C elimination during the COVID‐19 pandemic
Authors: Hartl Lukas , Jachs Mathias , Bauer David , Simbrunner Benedikt , Chromy David , Binter Teresa , Steininger Lisa , Schwarz Caroline , Schwarz Michael , Burghart Lukas , Strassl Robert , Trauner Michael , Gschwantler Michael , Mandorfer Mattias , Reiberger Thomas 
Published: September 2022

AbstractThe COVID‐19 pandemic necessitates healthcare restrictions that also affected ongoing hepatitis C virus (HCV) elimination efforts. We assessed the value of a physician‐operated HCV hotline on treatment and cure rates throughout the pandemic. All HCV patients undergoing HCV therapy at the Vienna General Hospital from 2019 to 2021 were included. An HCV hotline was established in 2019 and provided services including phone calls, text messages and voicemails. Patients were stratified by date of HCV therapy: 2019 (pre‐COVID) vs. 2020/2021 (during‐COVID) and use of the HCV hotline: users vs. non‐users. Overall, 220 patients were included (pre‐COVID: n = 91 vs. during‐COVID: n = 129). The prevalence of intravenous drug use (60.5%) and alcohol abuse (24.8%) was high during COVID. During COVID, the number of DAA treatment starts declined by 24.2% (n = 69) in 2020 and by 34.1% (n = 60) in 2021 vs. pre‐COVID (n = 91, 100%). Significantly more patients used the HCV hotline during‐COVID (95.3%) vs. pre‐COVID (65.9%; p < .001). Sustained virologic response (SVR) was 84.6% pre‐COVID and 86.0% during‐COVID. HCV hotline users achieved higher SVR rates during‐COVID (88.2% vs. 33.3%, p = .004), but also pre‐COVID (96.7% vs. 61.3%, p < .001) compared with non‐users. Considering only patients with completed DAA treatments, SVR rates remained similarly high during‐COVID (96.9%) versus pre‐COVID (98.1%). HCV treatment initiations decreased during‐COVID but importantly, nearly all DAA‐treated HCV patients used the HCV hotline during the COVID pandemic. Overall, the SVR rate remained at 88.2% during COVID and was particularly high in HCV phone users—most likely due to facilitation of adherence.
Researcher‐Supported Professional Learning and Development for Instructors in Adult L2 Programs: Factors Leading to Ongoing Communities of Practice
Authors: ABBOTT MARILYN L. , LEE KENT K. 
Published: September 2022

AbstractWe describe a longitudinal (5‐year) researcher‐supported initiative designed to strengthen the research–practice link (RPL) and serve as an effective form of situated professional learning and development (PLD) in adult second language programs. We facilitated the formation of and supported 9 professional reading groups of 6–12 instructors (N= 76). The groups met monthly to discuss peer‐reviewed journal articles to address shared PLD needs. Using retrodictive qualitative modeling, we traced the underlying factors in our RPL initiative that contributed to the rise of ongoing autonomous communities of practice in which instructors continued to engage in monthly cycles of implementing and adapting research knowledge and co‐constructed knowledge and practices gleaned from their reading and group discussions of peer‐reviewed articles. Data included participants’ responses to questionnaires, audio recordings of focus group interviews and reading group discussions, and researchers’ field notes. The results indicated that different types of communities of practice emerged over time through complex dynamic interactions between multiple factors in the RPL initiative (e.g., researchers, practitioners, and institutional and environmental forces). We discuss how researchers can strengthen the RPL by fostering the development of communities of practice that combine both research and practical knowledge to improve and create new educational practices.
To tip or not to tip: The Window of Tipping Point Analysis for social‐ecological systems
Authors: Riekhof Marie‐Catherine , Kluger Lotta Clara , Salvatteci Renato , Siebert Lotta , Voss Rudi 
Published: September 2022

AbstractWe introduce six steps to define a “Window of Tipping Point Analysis” which serves as a framework to increase the understanding of processes and tipping points in social‐ecological systems. We apply the Window of Tipping Point Analysis to a mathematical model and two case studies (i.e., Baltic Sea and the Humboldt Current Upwelling system), focusing on three aspects. In “to tip or be tipped” we look at agency in preventing (or driving) tipping. In “to be tipped or not to be tipped” we discuss intertemporal developments and chosen time periods for delineating regime shifts. In “to tip or not to tip” we discuss the desirability of states and their relation to the elements included. We argue that agency in tipping‐point management, the occurrence of tipping points, and desirable states depend on the window chosen for the analysis.
Normal range of ocular biometry in healthy children: A systemic review and meta‐analysis of 33,559 individuals under seven years of age
Authors: Chen Yanxian , Wang Wei , Wang Jun , Chen Xu , Zhu Zhuoting , Li Jinying , He Mingguang 
Published: September 2022

AbstractPurposeTo conduct a systemic review and meta‐analysis on the normative range of ocular biometry in healthy children under seven years of age.MethodsA literature search was performed using the PubMed (MEDLINE) database. The main outcomes were normative values of axial length (AL), central corneal thickness (CCT), cornea curvature (CC), anterior chamber depth (ACD), lens thickness (LT) and vitreous chamber depth (VCD). Pooled estimates were obtained with a random‐effects meta‐analysis. Multivariate meta‐regressions ascertained the moderator‐related trends.ResultsWe included 47 studies for a total of 33,559 subjects. The pooled ALs for 0.0–1.9 years, 2.0–3.9 years and 4.0–6.9 years were 18.33 mm (95% confidence interval [CI] 17.57–19.09), 21.71 mm (21.49–21.93) and 22.37 mm (22.29–22.45), respectively. Children aged 0.0–1.9 years had a greater CCT (576.70 μm, 567.20–586.21), steeper cornea (7.41 mm, 7.16–7.65) and shallower ACD (2.46 mm, 2.23–2.69). LT ranged from 3.65 to 3.74 mm for 0–6 years, and VCD increased from 11.94 mm at birth to 15.36 mm at 4.0–6.9 years. Differences in AL between East Asian and non‐East Asian children were found below two years of age (17.30 mm vs. 18.40 mm,p = 0.008) and for CC at 4.0–6.9 years of age (7.82 mm vs. 7.79 mm,p = 0.004). In a multivariate meta‐regression, AL, CC, ACD and VCD increased with age (p < 0.05 for all), while CCT decreased with age (p = 0.0007).ConclusionsThis study reports normative data for ocular biometry in children. Few differences were found with ethnicity in the ocular biometry of infants and pre‐schoolers.