bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association between PTPN22 C1858T polymorphism and juvenile idiopathic arthritis: A meta‐analysis update with trial sequential analysis
Authors: Lee Young Ho , Song Gwan Gyu 
Published: July 2022

AbstractOur aim was to determine whether protein tyrosine phosphatase nonreceptor 22 (PTPN22) C1858T polymorphism (rs2476601) is associated with susceptibility to juvenile idiopathic arthritis (JIA). MEDLINE and EMBASE databases were searched to identify articles in which PTPN22 C1858T polymorphism was reported to be identified in JIA patients and controls. A meta‐analysis was conducted to evaluate the association between PTPN22 C1858T polymorphism and RA using allelic contrast. Trial sequential analysis (TSA) was performed. Sixteen separate comparisons involving 5696 JIA patients and 9483 controls (a total of 15,179 subjects) were considered in this meta‐analysis. A meta‐analysis was performed with all JIA patients as well as JIA patients in each ethnic group. Meta‐analysis revealed an association between the T allele of PTPN22 C1858T polymorphism and JIA in all subjects (OR, 1.322; 95% CI, 1.233–1.418; p < .001). Analysis after stratification by ethnicity indicated that the T allele was significantly associated with JIA in the European population (OR, 1.312; 95% CI, 1.2211–1.410; p < .001). However, analysis performed in the non‐European population showed no significant association between the T allele and JIA. TSA indicated that the observed association between the PTPN22 polymorphism and JIA in all subjects and the European population is consistent with the existing evidence. This meta‐analysis confirms that PTPN22 C1858T polymorphism is associated with susceptibility to JIA in Europeans, and that no additional studies are needed to verify these results. However, current evidence in the non‐European population is insufficient, and further studies are warranted.
Internationally educated nurses and resilience: A systematic literature review
Authors: Dahl Kari , Nortvedt Line , Schrøder Judith , Bjørnnes Ann Kristin 
Published: July 2022

AbstractAimTo synthesize knowledge extracted from the literature about protecting factors and challenges to resilience, among migrant nurses, and specifically how knowledge synthesized through the process of the literature review is relevant to nursing and health policy.BackgroundHow nurses, in general, face challenges is well documented and is often linked to the concept of resilience; however, there seems to be a lack of systematic knowledge synthesis focusing on the resilience of internationally educated nurses following migration.MethodThe review was guided by the PRISMA guidelines, and a systematic search of peer‐reviewed qualitative and mixed‐method articles reporting empirical research was performed in the MEDLINE, CINAHL, PsycINFO and Academic Search Ultimate databases. Methodological rigour was assessed by the Joanna Briggs’ checklist, and a structured theme‐based ecological framework, inspired by Ungar's model of resilience, was chosen.ResultsFollowing critical appraisal, 37 studies were included that identified both challenges and individual, contextual and structural protective factors in host countries and are linked to resilience.DiscussionResilience of internationally educated nurses depends on a combination of individual and contextual protective factors, with the major emphasis being placed on individual protective factors. It is crucial to consider resilience in ensuring that internationally educated nurses’ experience is appreciated, as this is necessary if nurses are to deliver the best possible health service while integrating into their host country.Implication for nursing and health policyAuthorities, managers in clinical practice and education, trade unions and nurses in general should be aware of the coping strategies, the strengths and supportive factors that can promote resilience and be aware of the challenges that undermine resilience and negatively impact internationally educated nurses’ practice and social interactions.
The efficacy of topical sucralfate in improving pain and wound healing after haemorrhoidectomy procedure: A systematic review, meta‐analysis, and meta‐regression of randomised clinical trials
Authors: Rudiman Reno , Hanafi Ricarhdo Valentino , Evan Cecilia , Halim Freda 
Published: July 2022

AbstractPain and wound after haemorrhoidectomy constantly bothered the patient's convenience. Recurrently, topical sucralfate is used to treat excoriations and burns. It is considered to enhance epidermal growth and tissue granulation, thus, alleviating patients' problems. This study evaluated topical sucralfate's feasibility, safety, and superiority after haemorrhoidectomy. We searched randomised controlled trial (RCT) studies in PubMed, Google Scholar, Europe PMC, and ClinicalTrials.gov until March 29th, 2022. We investigated the influence of topical sucralfate on pain score postoperatively (24 hours, 7 days, and 14 days), pethidine usage, diclofenac usage, and wound healing rate compared to placebo. This study was conducted following the PRISMA guidelines. This study sorted the final six studies with 439 patients underwent haemorrhoidectomy. Topical sucralfate demonstrated significant outcomes on VAS 24 hours post‐operative [Std. Mean Difference −1.00 (95% CI −1.70, −0.31), P = .005], VAS 7 days post‐operative [Std. Mean Difference −2.29 (95% CI −3.34, −1.25), P < .0001], VAS 14 days post‐operative [Std. Mean Difference −1.88 (95% CI −2.74, −1.01), P < .0001], pethidine usage within 24 hours post‐operative [Std. Mean Difference −0.62 (95% CI −0.96, −0.27), P = .0004], diclofenac usage 7 days post‐operative [Std. Mean Difference −1.76 (95% CI −2.61, −0.92), P < .0001], diclofenac usage 14 days post‐operative [Std. Mean Difference −1.64 (95% CI −2.38, −0.91), P < .0001], and wound healing rate at 28‐day post‐operative [RR 1.45 (95% CI 1.25–1.68), P < .00001]. Topical sucralfate alleviated pain, improved wound healing, and minimised the usage of pethidine and diclofenac compared to placebo.
Kallistatin prevents ovarian hyperstimulation syndrome by regulating vascular leakage
Authors: Huang Jianfang , Mao Yuling , Li Quanxin , Hong Honghai , Tang Ni , Kang Xiangjin , Huang Yuling , Liu Jianqiao , Gong Qing , Yao Yachao , Li Lei 
Published: July 2022

AbstractAngiogenesis and increased permeability are essential pathological basis for the development of ovarian hyperstimulation syndrome (OHSS). Kallistatin (KS) is an endogenous anti‐inflammatory and anti‐angiogenic factor that participates in a variety of diseases, but its role in OHSS remains unknown. In this study, treating a human ovarian granulosa‐like tumour cell line KGN and human primary granulosa cells (PGCs) with human chorionic gonadotropin (hCG) reduced the expression of KS, but increased the expression of VEGF. Furthermore, we found that KS could attenuate the protein level of VEGF in both KGN cells and human PGCs. More interestingly, we observed that exogenous supplementation of KS significantly inhibited a series of signs of OHSS in mice, including weight gain, ovarian enlargement, increased vascular permeability and up‐regulation of VEGF expression. In addition, KS was proved to be safe on mice ovulation, progression of normal pregnancy and fetus development. Collectively, these findings demonstrated that KS treatment prevented OHSS, at least partially, through down‐regulating VEGF expression. For the first time, these results highlight the potential preventive value of KS in OHSS.
Modeling mass transfer during osmodehydration of apple cubes with sucrose or apple juice concentrate solutions: Equilibrium estimation, diffusion model, and state observer‐based approach
Authors: González‐Pérez Julio Emmanuel , Romo‐Hernández Aarón , Ramírez‐Corona Nelly , López‐Malo Aurelio 
Published: July 2022

AbstractThis article investigates the modeling aspects of mass transfer during osmodehydration of apple cubes. The obtained experimental data were fitted to three mathematical models: Azuara's equilibrium mass‐transfer model (AM), Fick's second law (FSL), and a Luenberger observer (LO). Two scenarios were considered for the mathematical modeling of mass transfer between the osmotic solution and the apple cubes. First, constant apple volume during the osmodehydration process was assumed. Then we included volume shrinkage in the dehydrated product as part of the model. The effect of the osmotic agent in the apple dehydration was also addressed by considering two different osmotic solutions, apple juice concentrate, and sucrose solutions, with different concentrations (40, 50, and 60 °Brix). The equilibrium parameters estimated with the AM model were similar to the parameters determined experimentally (p > .05). The LO model accurately describes the solute mass transfer dynamics during the osmodehydration process (R2 > .950). The overall findings indicate that considering the volume shrinkage as part of the model strongly influences the parameter estimation. When considering volume shrinkage in the FSL model, the estimated diffusivity parameters ranged from 1.26 to 5.05 × 10−10 m2/s for water and 0.68–19.35 × 10−10 m2/s for solutes, respectively. Not considering product shrinkage in the diffusivity model leads to overestimating both water diffusivity (29.9–76.8%) and solute diffusivity (25.3–52.8%).Practical ApplicationsOsmotic dehydration (OD) refers to a mass transfer process where solutes are transported from a hypertonic solution to a food material, while water moves from the food material towards the solution. OD improves the appearance and taste of dehydrated foods, helps inhibit the growth of dangerous microorganisms, and decreases enzymatic browning in some foods. Sucrose solutions are frequently used as osmotic solutions for food treatment in OD. An alternative to sucrose is to treat food with fruit juice concentrates. Fruit juice concentrates have low water activity and can provide bioactive compounds that enrich the dehydrated product. Understanding the effect of different factors on mass transfer during osmotic dehydration is thus critical for the efficient design, optimization, scaling‐up, and operation of OD food treatment processes. Furthermore, the proper selection of osmodehydration conditions allows us to obtain high‐quality food products with specific composition, textural/sensory properties, and microbiological characteristics. Therefore, osmotic dehydration is a food processing alternative that allows us to obtain high‐quality food products with good nutritional attributes.
Quo vadisMFA? Integrated material flow analysis to support material efficiency
Authors: Baars Joris , Rajaeifar Mohammad Ali , Heidrich Oliver 
Published: July 2022

AbstractMaterial efficiency (ME) strategies are pursued by governments and companies to reduce environmental emissions, improve supply chain resilience, and enhance cost competitiveness. Material flow analysis (MFA) methods are useful to quantify raw material stocks and flows and assess the potential impacts of ME strategies. Although the popularity of MFA methods is increasing, there are methodological limitations that hinder its use as a decision support tool for prospective assessments. To overcome some of these, MFA is increasingly integrated with other methods from different research fields. This paper categorizes integrated MFA methods by identifying and explaining the methods and their applications. A semi‐structured literature review screened a wide range of methods integrated with MFA prospective analysis and evaluated their applications from 158 studies. This showed that integrated MFA can be used to: (1) include economic, social, and environmental layers; (2) improve the technical foundation of MFA by including entropy and exergy analyses and process engineering methods; (3) include economic mechanisms and link the economic system to the material system; and (4) improve the representation of materials in existing methods and models. Our research demonstrates that integrated MFA should be a central method in planning and designing ME strategies for companies and governments. This paper provides an important knowledge base of integrated MFA methods and creates a discussion point on MFA, where the research field is currently at or indeed where it could be heading in the future, that is, “Quo Vadis” MFA.
Influence of COVID‐19 mRNA vaccination on the efficacy and safety of Botulinum toxin type A injections
Authors: Hamed Azzam Shirin , mukari Abed , Hamed Mira , Kridin Khalaf 
Published: July 2022

AbstractBackgroundConcerns have been raised recently regarding the efficacy and safety of Botulinum toxin type A (BTA) injections following COVID‐19 vaccination.AimsTo assess the influence of BNT162b2 mRNA vaccine on the safety and efficacy of BTA injections performed for aesthetic indications.MethodsA retrospective cohort study followed patients undergoing periodic BTA treatments who completed two doses of BNT162b2 vaccine. The latency between BTA injections before and after getting vaccinated was assessed for all study participants. Efficacy and longevity of BTA was reflected and evaluated by the latency between BTA injections. Patients were longitudinally monitored for the development of adverse events.ResultsForty‐five patients were eligible for inclusion in the current study. The mean (standard deviation [SD]) age of patients was 48.3 (8.9) years and 40 (88.9%) patients were females. The mean (SD) number of pre‐ and post‐COVID‐19 vaccination BTA injections was 5.1 (2.6) and 3.1 (0.4), respectively. The average (SD) interval between BTA injections after COVID‐19 vaccination (96.0 [12.3] days) was significantly shorter than before it (118.6 [22.7]; p < 0.001). No severe BTA‐associated adverse events were registered after the administration of BNT162b2 vaccine.ConclusionsOur findings indicate that BTA might be less effective after COVID‐19 vaccination. Further research is required to delineate the pathomechanism underlying this observation.
A new dexpanthenol‐containing liquid cleanser for atopic‐prone skin: Results from two prospective clinical studies evaluating cutaneous tolerability, moisturization potential, and effects on barrier function
Authors: Peltier Erwan , Trapp Sonja , de Salvo Raffaella , Sun Connie , Brandt Marianne , Laing Sabrina , Hennighausen Natascha , Barrionuevo‐Gonzalez Ana 
Published: July 2022

AbstractBackgroundGentle cleansing of the skin without further compromising its barrier function and moisture content and being simultaneously devoid of adverse effects on the skin microbiome are important features of body cleansers for atopic‐prone skin sufferers. For this population, a new dexpanthenol‐containing liquid cleanser (DCLC) was developed.MethodsTwo prospective 4‐week studies have been conducted. Study 1 investigated the effect of once‐daily DCLC on stratum corneum (SC) hydration, transepidermal water loss (TEWL), skin pH, and skin microbiome (all on the volar forearm) in adult subjects with dry skin (N = 44). Study 2 explored the cutaneous tolerability of DCLC and its effect on the microbiome biodiversity of the volar forearm skin in infants/children with atopic‐prone skin (N = 33, aged 6 months to 6 years). In the latter study, DCLC was applied 2–3 days/week in combination with an emollient applied at least twice daily.ResultsIn Study 1, on Day 29, the mean change in skin surface capacitance from baseline was significantly greater in the forearm test area treated with DCLC than in the contralateral test area (control) treated with water only (5.16 vs. 3.65 a.u.; p = 0.011), suggesting long‐term SC hydration. DCLC use was not associated with changes in TEWL, skin pH, or microbiome biodiversity if compared to control. In Study 2, the 4‐week use of DCLC in combination with an emollient was well tolerated according to pediatrician skin assessment, and no flare‐ups were recorded. The microbiome biodiversity did not shift during the study.ConclusionThese findings support the use of DCLC in subjects with atopic‐prone skin.
Constitutive expression of JASMONATE RESISTANT 1 induces molecular changes that prime the plants to better withstand drought
Authors: Mahmud Sakil , Ullah Chhana , Kortz Annika , Bhattacharyya Sabarna , Yu Peng , Gershenzon Jonathan , Vothknecht Ute C. 
Published: July 2022

AbstractIn this study, we investigated Arabidopsis thaliana plants with altered levels of the enzyme JASMONATE RESISTANT 1 (JAR1), which converts jasmonic acid (JA) to jasmonoyl‐l‐isoleucine (JA‐Ile). Analysis of a newly generated overexpression line (35S::JAR1) revealed that constitutively increased JA‐Ile production in 35S::JAR1 alters plant development, resulting in stunted growth and delayed flowering. Under drought‐stress conditions, 35S::JAR1 plants showed reduced wilting and recovered better from desiccation than the wild type. By contrast, jar1‐11 plants with a strong reduction in JA‐Ile content were hypersensitive to drought. RNA‐sequencing analysis and hormonal profiling of plants under normal and drought conditions provided insights into the molecular reprogramming caused by the alteration in JA‐Ile content. Especially 35S::JAR1 plants displayed changes in expression of developmental genes related to growth and flowering. Further transcriptional differences pertained to drought‐related adaptive systems, including stomatal density and aperture, but also reactive oxygen species production and detoxification. Analysis of wild type and jar1‐11 plants carrying the roGFP‐Orp1 sensor support a role of JA‐Ile in the alleviation of methyl viologen‐induced H2O2 production. Our data substantiate a role of JA‐Ile in abiotic stress response and suggest that JAR1‐mediated increase in JA‐Ile content primes Arabidopsis towards improved drought stress tolerance.
The effects of nusinersen treatment on respiratory status of children with spinal muscular atrophy
Authors: Hepkaya Evrim , Kılınç Sakallı Ayşe Ayzıt , Ülkersoy İpek , Başkan Azer Kılıç , Arslan Hüseyin , Meral Özge , Dilek Tuğçe Damla , Güler Serhat , Saltık Sema , Çokuğraş Haluk 
Published: July 2022

AbstractBackgroundRespiratory involvement is the main factor predicting the prognosis of spinal muscular atrophy (SMA). Significant responses in motor functions have been demonstrated with nusinersen, but pulmonary outcomes are still varied. We aimed to explore the effects of nusinersen on the respiratory functions of patients with SMA.MethodsPatients with SMA who were receiving regular nusinersen treatment in our tertiary care hospital were enrolled in this study. We evaluated the patients in terms of the necessity to ventilatory or nutritional support, presence of motor involvement and other comorbidities related with prognosis at three consecutive assessments.ResultsThe study group consisted of 43 patients (18 type 1, 12 type 2, and 13 type 3) with SMA with a mean age of 27.8 months at diagnosis and 60.8 months at the beginning of nusinersen treatment. The respiratory function improvements were noted in six patients at third assessment. Early initiation of nusinersen was significantly correlated with reduced hospital admissions (P = 0.026). Nutritional support and weight gain were remarkable in the ventilatory‐supported group. Children's Hospital of Philadelphia Infant Test of Neuromuscular Disorders scores were significantly higher in the non‐tracheostomized group in patients with SMA type 1 (P < 0.005).ConclusionsWe posit that nusinersen may change the natural prognosis of SMA and improve care of children with SMA. Following up children with SMA for longer periods under nusinersen may be beneficial for understanding the effects of treatment. Results of our study need to be supported by future long‐term studies to reach a consensus on nusinersen, considering the overall genetic and environmental status as well as the cost‐effectiveness of the treatment.
African Philosophy of Religion: Concepts of God, Ancestors, and the Problem of Evil
Authors: Cordeiro‐Rodrigues Luís , Agada Ada 
Published: July 2022

AbstractThere has recently been an increased interest in debates on the nature of God, supernatural entities, and the problem of evil outside the Western tradition and there is a growing realisation that philosophical scholarship should go beyond Western perspectives in order to properly address issues in the philosophy of religion that arise in non‐Western cultures. Taking this on board, this article surveys the field of African philosophy of religion and highlights some of the concerns and issues driving debates in the field. In particular, we focus on three important debates. Firstly, we outline the two main schools of thought that divide African philosophers into theistic and non‐theistic camps. We label the theistic perspective the 'African theistic view' and the non‐theistic perpective the 'limited God view'. Secondly, we explore how commitment to the two views has led to distinct explanations of the problem of evil. Thirdly, we highlight the role of ancestors in African belief‐systems and their place in the scheme of things. Adopting the method of philosophical exposition and argument, we show how the two dominant views of God's nature define this emerging field of African philosophy and will determine the future trajectory of the field.
Effects of emotion and semantic relatedness on recognition memory: Behavioral and electrophysiological evidence
Authors: Han Meng , Li Bingcan , Guo Chunyan , Tibon Roni 
Published: July 2022

AbstractSome aspects of our memory are enhanced by emotion, whereas others can be unaffected or even hindered. Previous studies reported impaired associative memory of emotional content, an effect termed associative “emotional interference”. The current study used EEG and an associative recognition paradigm to investigate the cognitive and neural mechanisms associated with this effect. In two experiments, participants studied negative and neutral stimulus‐pairs that were either semantically related or unrelated. In Experiment 1 emotions were relevant to the encoding task (valence judgment) whereas in Experiment 2 emotions were irrelevant (familiarity judgment). In a subsequent associative recognition test, EEG was recorded while participants discriminated between intact, rearranged, and new pairs. An associative emotional interference effect was observed in both experiments, but was attenuated for semantically related pairs in Experiment 1, where valence was relevant to the task. Moreover, a modulation of an early associative memory ERP component (300–550 ms) occurred for negative pairs when valence was task‐relevant (Experiment 1), but for semantically related pairs when valence was irrelevant (Experiment 2). A later ERP component (550–800 ms) showed a more general pattern, and was observed in all experimental conditions. These results suggest that both valence and semantic relations can act as an organizing principle that promotes associative binding. Their ability to contribute to successful retrieval depends on specific task demands.