bluuebunny/crossref_metadata_2025_split huggingface dataset:
The modified vermilion border‐marionette line approach: A management for buccal cancer with wider indications and higher satisfaction
Authors: Li Bo , Cheng Aoming , Liu Huan , Wang Hao , Wang Chong , Xu Qiaoshi , Han Zhengxue , Feng Zhien 
Published: August 2022

AbstractObjectiveThe purpose of this study is to explore the effects of modified vermilion border‐marionette line (MVBML) approach on postoperative facial scar, nerves injury, and prognosis of patients with buccal squamous cell carcinoma (BSCC).Patients and MethodsThis is a single‐center, prospective cohort study that enrolled 80 patients with BSCC from June 2015 to December 2020. According to the different surgical approaches, the patients were divided into two groups: the lower lip median (LLM) approach group and the MVBML approach group.ResultsThe results showed that the appearance (p = 0.003), scar consciousness (p < 0.001) and satisfaction with appearance (p = 0.001) of patients in the MVBML group were significantly better than those in the LLM group, and the difference was more obvious in elderly group. Statistical analysis of postoperative nerves injury showed that the MVBML group had a lower risk of facial and mental nerves injury than the LLM group, and there was a significant statistical difference in mental nerve injury between the two groups (p < 0.001). Through Kaplan–Meier survival analysis, we found no significant difference in disease‐specific survival (p = 0.47) or disease‐free survival (p = 0.70) between the LLM approach group and the MVBML approach group.ConclusionsThe MVBML surgical approach is worthy of advancement for the surgical treatment of BSCC.
Safety of antifibrinolytics in 6583 pediatric patients having craniosynostosis surgery: A decade of data reported from the multicenter Pediatric Craniofacial Collaborative Group
Authors: King Michael R. , Staffa Steven J. , Stricker Paul A. , Pérez‐Pradilla Carolina , Nelson Olivia , Benzon Hubert A. , Goobie Susan M. ,   the Pediatric Craniofacial Collaborative Group
Published: August 2022

AbstractBackgroundAntifibrinolytics such as tranexamic acid and epsilon‐aminocaproic acid are effective at reducing blood loss and transfusion in pediatric patients having craniofacial surgery. The Pediatric Craniofacial Collaborative Group has previously reported low rates of seizures and thromboembolic events (equal to no antifibrinolytic given) in open craniofacial surgery.AimsTo query the Pediatric Craniofacial Collaborative Group database to provide an updated antifibrinolytic safety profile in children given that antifibrinolytics have become recommended standard of care in this surgical population. Additionally, we include the population of younger infants having minimally invasive procedures.MethodsPatients in the Pediatric Craniofacial Collaborative Group registry between June 2012 and March 2021 having open craniofacial surgery (fronto‐orbital advancement, mid and posterior vault, total cranial vault remodeling, intracranial LeFort III monobloc), endoscopic cranial suture release, and spring mediated cranioplasty were included. The primary outcome is the rate of postoperative complications possibly attributable to antifibrinolytic use (seizures, seizure‐like activity, and thromboembolic events) in infants and children undergoing craniosynostosis surgery who did or did not receive antifibrinolytics.ResultsForty‐five institutions reporting 6583 patients were included. The overall seizure rate was 0.24% (95% CI: 0.14, 0.39%), with 0.20% in the no Antifibrinolytic group and 0.26% in the combined Antifibrinolytic group, with no statistically reported difference. Comparing seizure rates between tranexamic acid (0.22%) and epsilon‐aminocaproic acid (0.44%), there was no statistically significant difference (odds ratio = 2.0; 95% CI: 0.6, 6.7; p = .257). Seizure rate was higher in patients greater than 6 months (0.30% vs. 0.18%; p = .327), patients undergoing open procedures (0.30% vs. 0.06%; p = .141), and syndromic patients (0.70% vs. 0.19%; p = .009).ConclusionsThis multicenter international experience of pediatric craniofacial surgery reports no increase in seizures or thromboembolic events in those that received antifibrinolytics (tranexamic acid and epsilon‐aminocaproic acid) versus those that did not. This report provides further evidence of antifibrinolytic safety. We recommend following pharmacokinetic‐based dosing guidelines for administration.
Water taken up through the bark is detected in the transpiration stream in intact upper‐canopy branches
Authors: Gimeno Teresa E. , Stangl Zsofia R. , Barbeta Adrià , Saavedra Noelia , Wingate Lisa , Devert Nicolas , Marshall John D. 
Published: August 2022

AbstractAlternative water uptake pathways through leaves and bark complement water supply with interception, fog or dew. Bark water‐uptake contributes to embolism‐repair, as demonstrated in cut branches. We tested whether bark water‐uptake could also contribute to supplement xylem‐water for transpiration. We applied bandages injected with 2H‐enriched water on intact upper‐canopy branches of Pinus sylvestris and Fagus sylvatica in a boreal and in a temperate forest, in summer and winter, and monitored transpiration and online isotopic composition (δ2H and δ18O) of water vapour, before sampling for analyses of δ2H and δ18O in tissue waters. Xylem, bark and leaf waters from segments downstream from the bandages were 2H‐enriched whereas δ18O was similar to controls. Transpiration was positively correlated with 2H‐enrichment. Isotopic compositions of transpiration and xylem water allowed us to calculate isotopic exchange through the bark via vapour exchange, which was negligible in comparison to estimated bark water‐uptake, suggesting that water‐uptake occurred via liquid phase. Results were consistent across species, forests and seasons, indicating that bark water‐uptake may be more ubiquitous than previously considered. We suggest that water taken up through the bark could be incorporated into the transpiration stream, which could imply that sap‐flow measurements underestimate transpiration when bark is wet.
Lipoid proteinosis: Novel ECM1 pathogenic variants and intrafamilial variability in four unrelated Arab families
Authors: Li Mingfeng , Fischer Judith , Safwat Sylvia , Shoman Walaa , Chazli Yasmine El , Alter Svenja , Has Cristina , Abdalla Ebtesam 
Published: August 2022

AbstractBackground/objectivesLipoid proteinosis (LP) is a rare autosomal recessive multisystem disorder that is caused by loss‐of‐function pathogenic variants in the extracellular matrix protein‐1 (ECM1) gene. The typical clinical manifestations of LP include hoarseness of voice, beaded papules on the eyelids, infiltration and scarring of the skin and mucosa, as well as neuropsychological abnormalities. Currently, more than 70 pathogenic variants have been reported, including nonsense, missense, splice site, deletion and insertion pathogenic variants, and more than half of them occurred in exons 6 and 7.MethodsClinical evaluation and Sanger sequencing were performed on eight patients from four unrelated Arab families.ResultsWe identified two novel ECM1 variants, one nonsense pathogenic variant in exon 6 (c.579G>A, p.Trp193*) and a deletion of three nucleotides (c.1390_1392del, p.Glu464del) in exon 9, and two previously reported frameshift variants; c.692_693delAG, in exon 6 and c.11dupC in exon 1.ConclusionsAlthough all patients had characteristic manifestations of lipoid proteinosis, we observed intrafamilial phenotypic variability. Our data expand the pathogenic variant spectrum of ECM1 and also supports the fact that exon 6 is one of the most common hot spots of pathological variants in ECM1.
Breaking‐up is hard to study: A review of two decades of dissolution research
Authors: Machia Laura V. , Niehuis Sylvia , Joel Samantha 
Published: August 2022

AbstractThe dissolution of romantic relationships can be conceptualized in many ways, from a distressing event or a consequential life decision to a metric of a relationship's success. In the current review, we assess how relationship science has approached dissolution research over roughly the past 20 years. We identified 207 studies (from 195 papers) published between 2002–2020 that captured relationship dissolution events and coded the papers for relevant features. The most common methodological approach to studying breakups was a self‐report study (92%) in which relationships were tracked over time (72%) and breakups were treated as an outcome variable (79%). These results suggest that most research on dissolution has focused on predictors of it, rather than processes required to uncouple and circumstances surrounding the breakup itself. Coding revealed heterogeneous theoretical approaches, with the most common perspective across papers—social exchange/interdependence theory—informing only 15% of the papers coded. A majority (61%) of samples were representative of the nations, regions, or localities in which the studies were conducted. Yet, samples still tended to be disproportionately comprised of young, white individuals from Western countries. We conclude by discussing potential avenues for moving our understanding of relationship dissolution forward.
Presidential Strategy amidst the “Broken” Appointments Process
Authors: Piper Christopher 
Published: August 2022

AbstractOne of the notable features of the most recent presidential administrations has been the increasing prevalence of vacancies in presidentially appointed and Senate‐confirmed positions. This article explains when and how presidents actively take control of those positions once they become vacant. It evaluates its claims with original data on the most important Senate‐confirmed positions during the first year of the Obama, Trump, and Biden administrations, with a total of nearly 5,000 quarterly observations of 1,009 administration‐position cases. Estimates from Markov multistate models reveal that presidents use non‐default acting officials more frequently in ideologically opposed agencies, agencies connected to their campaign priorities, and the highest tier of leadership positions. Further, presidents pursue confirmation sparingly, often opting instead to use non‐default acting officials for extended periods of time. These results suggest that presidents have significant discretion over the leadership of the executive establishment that is at odds with our separation of powers system of government and the Senate's constitutional role to provide advice and consent on presidential appointees.
Effect of peri‐conception high‐fat diets on maternal ovarian function, foetal and placentome growth, and vascular umbilical development in goats
Authors: Cavalcanti Camila Muniz , Silva Maria Raquel Lopes , Conde Alfredo José Herrera , Bezerra Alessandra Façanha , Alves Juliana Paula Martins , Fernandes César Carneiro Linhares , Teixeira Dárcio Ítalo Alves , Rêgo Anibal Coutinho , Rondina Davide 
Published: August 2022

AbstractThe objective of this study was to determine whether a high‐fat diet (HFD) fed to goats for a brief period during peri‐conception would optimize reproductive and foetal responses. Thirty‐four Anglo‐Nubian crossbred adult goats were allocated into three groups: control (n = 11), fed with a total mixed ration (TMR) based on chopped elephant grass and concentrate; HFBM (n = 11), given TMR supplemented with soybean oil on a 0.5% dry matter basis for 11 days starting nine days before mating (BM); and HFAM (n = 12), fed with soybean oil included in the TMR for 15 days after mating (AM). The TMR diets differed in their fat content (7.5% vs. 2.9%). All goats had oestrus synchronized for 14 days BM by intravaginal administration of 60 mg MPA sponge for 12 days. Forty‐eight hours BM, the sponge was removed and 0.075 mg PGF2α was applied intramuscularly. After 36 h, 1 ml GnRH was administered intramuscularly, and goats were mated after sponge removal. The fat groups showed lower feed intake (p < .001) and higher cholesterol levels (p < .001) when HFD was administered. Doppler and B‐mode ultrasound evaluations revealed a greater (p < .05) number of small (<3 mm, 10 ± 0.6 vs. 8 ± 0.5) and large (≥3 mm, 6 ± 0.4 vs. 5.0 ± 0.2) follicles and intraovarian blood area (p < .05) in the HFBM group during sponge removal (57.6%) and mating (24.2%) than those of the no‐fat group. During AM, the fat‐fed groups exhibited higher glutathione peroxidase levels (p < .05) and a reduction (p < .001) in corpus luteum size (19%) and vascularized Doppler area (41%). No difference (p > .05) between groups was found in foetal traits, placentome and umbilical vascular development, except for the embryonic vesicle where HFAM twin pregnancy showed a smaller size than the control (26.1 ± 3.5 cm vs. 33.7 ± 2.7 cm; p < .01). Thus, HFD applied during peri‐conception of goats has no impact on later foetal development but improved the follicular growth when given before the mating. Thus, the use of HFD in periconception has no impact on foetal development but increases follicular growth before breeding time.
Barriers and Enablers Influencing Women's Adoption and Continuation of Vaginally Inserted Contraceptive Methods: A Literature Review
Authors: Harris Danielle M. , Dam Anita , Morrison Kate , Mann Chastain , Jackson Ashley , Bledsoe Shannon M. , Rowan Andrea , Longfield Kim 
Published: August 2022

AbstractMost vaginally inserted methods have limited availability and use despite offering characteristics that align with many women's stated preferences (e.g., nonhormonal and/or on demand). The objective of this review was to identify enablers and barriers to women's adoption and continuation of vaginally inserted contraceptive methods in low‐ and middle‐income countries (LMICs). We searched three databases (PubMed, Embase, and Web of Science) and 18 websites using keywords related to five vaginally inserted contraceptive methods (diaphragm, vaginal ring, female condom, copper intrauterine device [IUD], hormonal IUD) and terms associated with their adoption and continuation. Searches were limited to resources published between January 2010 and September 2020. Studies eligible for inclusion in our review presented results on women's use and perspectives on the enablers and barriers to adoption and continuation of the vaginally inserted contraceptive methods of interest in LMICs. Relevant studies among women's partners were also included, but not those of providers or other stakeholders. Data were coded, analyzed, and disaggregated according to a framework grounded in family planning (FP) literature and behavioral theories common to FP research and program implementation. Our initial search yielded 13,848 results, with 182 studies ultimately included in the analysis. Across methods, we found common enablers for method adoption, including quality contraceptive counseling as well as alignment between a woman's preferences and a method's duration of use and side effect profile. Common barriers included a lack of familiarity with the methods and product cost. Notably, vaginal insertion was not a major barrier to adoption in the literature reviewed. Vaginally inserted methods of contraception have the potential to fill a gap in method offerings and expand choice. Programmatic actions should address key barriers and enable voluntary use.
Effectiveness of HIIT in patients with cancer or cancer survivors: An umbrella and mapping review with meta‐meta‐analysis
Authors: Herranz‐Gómez Aida , Cuenca‐Martínez Ferran , Suso‐Martí Luis , Varangot‐Reille Clovis , Calatayud Joaquín , Blanco‐Díaz María , Casaña José 
Published: August 2022

ObjectiveTo assess the available evidence on the effectiveness of high‐intensity interval training (HIIT) in addition to first‐choice cancer treatment on cardiorespiratory fitness (CRF), quality of life (QoL), adherence, and adverse effects of HIIT in patients with cancer or cancer survivors.MethodsAn umbrella review and meta‐meta‐analysis (MMA) was performed. A systematic search was conducted in MEDLINE, EMBASE, Cochrane Database, CINAHL, Scopus, SPORTDiscus, and Web of Science until August 2021. Article selection, quality assessment, and risk of bias assessment were performed by two independent reviewers. The MMA were performed with a random‐effects model and the summary statistics were presented in the form of forest plot with a weighted compilation of all standardized mean differences (SMD) and corresponding 95% confidence interval (CI).ResultsSeven systematic reviews were included. Regarding CRF, the addition of HIIT to cancer treatment showed statistically significant differences with a small clinical effect, compared with adding other treatments (SMD = 0.45; 95% CI 0.24 to 0.65). There was no significant difference when compared with adding moderate‐intensity continuous training (MICT) (SMD = 0.23; 95% CI −0.04 to 0.50). QoL showed positive results although with some controversy. Adherence to HIIT intervention was high, ranging from 54% to 100%. Regarding adverse effects, most of the systematic reviews reported none, and in the cases in which they occurred, they were mild.ConclusionIn conjunction with first‐choice cancer treatment, HIIT has been shown to be an effective intervention in terms of CRF and QoL, as well as having optimal adherence rate. In addition, the implementation of HIIT in patients with cancer or cancer survivors is safe as it showed no or few adverse effects.
The archipelago of meaning: Methodological contributions to the study of Vanuatu sand drawing
Authors: Devylder Simon 
Published: August 2022

AbstractVanuatu sand drawing has been listed by UNESCO since 2006 and has both fascinated and puzzled researchers from various disciplines for over a century. The inherent multi‐dimensionality of the practice makes analysis complex, and until very recently developing a systematic methodology to study this intangible art form was difficult. This paper aims to contribute to filling this gap with the analysis of a corpus of sand drawings documented on the island of Paama in 2019. A detailed methodological toolkit is proposed to better understand the complex morphology of the drawings and their multi‐layered meaning and function. This paper offers the first few steps along a journey toward designing integrated comparative methods of analysis that can not only potentiate unprecedented insights into the cultural practice of Vanuatu sand drawing, but also more broadly help us understand how worldviews, beliefs and societal structures spread across time and space.
On Choosing the Optimal Impeller Exit Velocity Triangles in Preliminary Design
Authors: Lou Fangyuan , Key Nicole L. 
Published: August 2022

Abstract
Impeller discharge flow plays an important role in centrifugal compressor performance and operability for two reasons. First, it determines the work factor and relative diffusion for the impeller. Second, it sets the flow into the downstream stationary diffusion system. The choice made in the preliminary design phase for the impeller exit velocity triangle is crucial for a successful design. The state-of-the-art design approach for determining the impeller exit velocity triangle in the preliminary design phase relies on several empirical guidelines, i.e., maximum work factor and diffusion ratio for an impeller, the optimal range of absolute flow angle, etc. However, as modern compressors continue pushing toward higher efficiency and higher work factor, this design approach falls short in providing exact guidance for choosing an optimal impeller exit velocity triangles due to its empirical nature as well as the competing mechanism of the two trends. In light of this challenge, this paper introduces a reduced-dimension, deterministic approach for the design of the impeller exit velocity triangle. The method gauges the design of the impeller exit velocity triangle from a different design philosophy using a relative diffusion effectiveness parameter and is validated using six impeller designs, representative of applications in both turbochargers and aero engines. Furthermore, with the deterministic method in place, optimal impeller exit velocity triangles are explored over a broad design space, and a one-to-one mapping from a selection of impeller total-to-total pressure ratios and backsweep angles to a unique optimal impeller exit velocity triangle is provided. This new approach is demonstrated, and discussions regarding the influences of impeller total-to-total pressure ratio, isentropic efficiency, and backsweep angle on the optimal impeller exit velocity triangle are presented.
Distributed Stochastic Consensus of Networked Nonholonomic Mobile Robots and Its Formation Application
Authors: Liu Lixia , Ji Jinchen , Li Bin , Miao Zhonghua , Zhou Jin 
Published: August 2022

Abstract
This paper proposes a novel distributed stochastic consensus seeking algorithm for networked nonholonomic wheeled mobile robots (NNWMRs) and its application to consensus-based formation. Time-varying delays and noisy measurement are incorporated into the dynamic model to represent two key issues inherently appearing in the communication and information exchange process among robots. Based on backstepping technique and sliding mode approach, the proposed consensus algorithm integrates kinematic controller and dynamic torque controller into the control protocol. A key feature of the proposed consensus algorithm is the introduction of the consensus gains, which characterizes the effects of time delays and noisy measurement. A unified methodology is provided for the convergence analysis of the networked system by using the generalized stochastic delayed Halanay inequality. It is shown that time delays and noisy measurement can play crucial roles in distributed consensus seeking in collaborative multirobot systems. Illustrative examples and simulations are provided to demonstrate and validate the theoretical results.
Self-Compassionate Motivation and Athlete Well-Being: The Critical Role of Distress Tolerance
Authors: Walton Courtney C. , Lewis Kelsey J. , Kirby James , Purcell Rosemary , Rice Simon M. , Osborne Margaret S. 
Published: August 2022

This cross-sectional study explored athlete responses to the Compassion Motivation and Action Scales Self-Compassion Scale, examining its relationship with well-being. Athlete (N = 207; mean age 27.9 years) scores were consistent with previous population means. Scores on the Compassion Motivation and Action Scales Self-Compassion Scale did not differ between elite and nonelite athletes, nor did they correlate significantly with trait competitiveness. Significant differences emerged based on athlete well-being state, with athletes categorized as “flourishing” scoring higher on the total score and all subscales of the Compassion Motivation and Action Scales Self-Compassion Scale, as compared with those with “moderate mental health” (Cohen’s ds from 0.58 to 0.92). Furthermore, the distress tolerance subscale significantly mediated the relationship between self-compassion intentions and well-being (indirect path: B = 0.034, p < .001). The results suggest that self-compassionate intentions are not enough, and athletes may need support to tolerate the distress that comes with moving toward one’s own suffering.