bluuebunny/crossref_metadata_2025_split huggingface dataset:
GEO: Enhancing Combinatorial Optimization with Classical and Quantum Generative Models
Authors: Alcazar Francisco Fernandez , Perdomo-Ortiz Alejandro , Vakili Mohammad Ghazi , Kalayci Can 
Published: August 2022

Abstract

We introduce a new framework that leverages machine learning models known as generative models to solve optimization problems. Our Generator-Enhanced Optimization (GEO) strategy is flexible to adopt any generative model, from quantum to quantum-inspired or classical, such as Generative Adversarial Networks, Variational Autoencoders, or Quantum Circuit Born Machines, to name a few. Here, we focus on a quantum-inspired version of GEO relying on tensor-network Born machines and referred to hereafter as TN-GEO. We present two prominent strategies for using TN-GEO. The first uses data points previously evaluated by any quantum or classical optimizer, and we show how TN-GEO improves the performance of the classical solver as a standalone strategy in hard-to-solve instances. The second strategy uses TN-GEO as a standalone solver, i.e., when no previous observations are available. Here, we show its superior performance when the goal is to find the best minimum given a fixed budget for the number of function calls. This might be ideal in situations where the cost function evaluation can be very expensive. To illustrate our results, we run these benchmarks in the context of the portfolio optimization problem by constructing instances from the S&P 500 and several other financial stock indexes. We show that TN-GEO can propose unseen candidates with lower cost function values than the candidates seen by classical solvers. This is the first demonstration of the generalization capabilities of quantum-inspired generative models that provide real value in the context of an industrial application. We also comprehensively compare state-of-the-art algorithms in a generalized version of the portfolio optimization problem. The results show that TN-GEO is among the best compared to these state-of-the-art algorithms; a re- markable outcome given the solvers used in the comparison have been fine-tuned for decades in this real-world industrial application. We see this as an important step toward a practical advantage with quantum-inspired models and, subsequently, with quantum generative models.
Application of procalcitonin, C-reactive protein and white blood cell count for the rapid diagnosis of Clostridium difficile infection in patients with inflammatory bowel disease
Authors: Xie Shuhua , Wu Zhongwen , Chen Peisong , Wang Dong , Liao Kang , Liu Min , Zhang Shihong , Chen Yili 
Published: August 2022

Abstract
Background: The incidence of Clostridium difficile infection (CDI) has increased in recent years in patients with inflammatory bowel disease (IBD). C. difficile is a toxin-producing bacterium, and CDI results in the worsening of the underlying IBD, increasing the risks of IBD treatment failure, surgery and hospitalization. Since the symptoms of CDI overlap with those of IBD, it is challenging to make a differential diagnosis. Therefore, early, rapid and reliable diagnostic tools that can identify CDI in IBD patients would be valuable to clinicians. Methods: This study enrolled 135 patients with IBD. Among them, 44 patients were diagnosed with CDI, and 42 patients were diagnosed with viral or fungal infections; 49 patients without infections were enrolled in the control group. The diagnostic values of procalcitonin (PCT), C-reactive protein (CRP) and the white blood cell count (WBC) in the peripheral blood were examined. A receiver operating characteristic (ROC) curve was used to analyse the diagnostic value of these parameters. Results: In this study, the PCT and CRP levels were significantly higher in patients with CDI than in non-CDI patients (including patients with viral/fungal infections and the control group; p<0.001 and p<0.05, respectively). In the ROC curve analysis of the IBD-CDI group and the control group, PCT and CRP predicted IBD-CDI with an area under the curve (AUC) of 0.826 [95% confidence interval (CI) 0.743–0.909, p=0.000] and 0.663 [95% confidence interval (CI) 0.551–0.774, p=0.007], respectively. The WBC count was inferior as diagnostic tool for CDI. The sensitivity was 56.82% (95% CI: 41.03% to 71.65%), the specificity was 91.84% (95% CI: 80.40% to 97.73%), and the LR (+) was 6.96 for PCT for the diagnosis of CDI. Conclusions: The present study demonstrated the superiority of PCT over CRP and the WBC for the rapid diagnosis of CDI in IBD patients. Additionally, PCT can be used to predict the clinical outcomes.
Climatic projections of Western India using global and regional climate models
Authors: Shaikh Mohdzuned Mohmedraffi , Lodha Pradeep , Lalwani Prashant , Mehta Darshan 
Published: August 2022

Abstract
This research work aimed to project and analyze climatic variability using GCMs and RCMs in the Hathmati River Basin, which happens to be one of the most important tributaries of Western India. The analysis included a baseline period from 1980 to 2014 and a future scenario (2050s) under a representative concentration pathway (RCP4.5). Following the evaluation of bias correction methods, distribution mapping and power transformation were used for temperature and precipitation projection, respectively. The 2050 s RCP4.5 simulations showed an increase in precipitation to 1,015.54 mm from 936.91 mm giving around a 8.45% increase in average precipitation. For temperature, the maximum temperature was around a 7.05% increase taking the average temperature to 34.21 from 33.97. The minimum temperature was 20.24 from 20.41 showing a positive change of around 8.4%. The future precipitation and temperature change projected might worsen the water stress and increase the probability of the occurrence of severe events, and hence mitigation strategies and management options to reduce this negative impact should be encouraged.
Oxygen aeration efficiency of gabion spillway by soft computing models
Authors: Srinivas Rathod , Tiwari Nand Kumar 
Published: August 2022

AbstractThe current paper deals with the performance evaluation of the application of three soft computing algorithms such as adaptive neuro-fuzzy inference system (ANFIS), backpropagation neural network (BPNN), and deep neural network (DNN) in predicting oxygen aeration efficiency (OAE20) of the gabion spillways. Besides, classical equations, namely multivariate linear and nonlinear regressions (MVLR and MVNLR), including previous studies, were also employed in predicting OAE20 of the gabion spillways. The analysis of results showed that the DNN demonstrated relatively lower error values (root mean square error, RMSE = 0.03465; mean square error, MSE = 0.00121; mean absolute error, MAE = 0.02721) and the highest value of correlation coefficient, CC = 0.9757, performed the best in predicting OAE20 of the gabion spillways; however, other applied models, such as ANFIS, BPNN, MVLR, and MVNLR, were giving comparable results evaluated to statistical appraisal metrics of the relative significance of input parameters based on sensitivity investigation, the porosity (n) of gabion materials was observed to be the most critical parameter, and gabion height (P) had the least impact over OAE20 of the spillways.
Efficiencies and mechanism of enhanced coagulation pre-treatment on domestic sewage with PAC-HCA compound
Authors: Yan Zichun , Shen Li , Pei Zhibing , Yang Mingxia , Zhang Wei 
Published: August 2022

Abstract
Poly dimethyl diallyl propyl ammonium chloride (HCA) and poly aluminum chloride (PAC) were used to prepare complex coagulants for the enhanced coagulation (EC) pretreatment of domestic sewage. The influences of hydraulic conditions, the dosage ratio of PAC-HCA complex coagulants, initial pH value, and dosage on the removal efficiency of SS, COD, and TP in domestic sewage were investigated. The fractal dimension and Zeta potential were used to verify and characterize the experimental results. The results showed that the optimum coagulant conditions were as follows: G1 = 200.0–265.0 s−1, T1 = 1.5 min, G2 = 40.0 s−1, T2 = 5 min, PAC: HCA = 25:1, dosage = 15 mL/L, pH = 8. At the mentioned point, the removal rates of SS, COD, and TP are 98.74%, 44.63%, and 89.85%, respectively. In addition, through comparative tests, PAC-HCA compound coagulants show better treatment efficiency than PAC and HCA used alone. When the HCA dosage was 15 mg/L, Zeta potential and flocs fractal dimension was 2.29 mv and 0.9844, respectively. This indicates that PAC-HCA has a good treatment effect on domestic sewage, and the mechanism of enhanced coagulation to remove nutrients is mainly electrical neutralization.
Pengaruh Berbagai Komposisi Media Tanam Pada Pertumbuhan dan Hasil Tanaman Bawang Merah (Allium ascalonicum L.) Varietas Bauji
Authors: Damayanti Erlinda , Barunawati Nunun 
Published: August 2022

Komoditas Bawang Merah memiliki peluang bisnis yang besar di Indonesia. Sebagai salah satu bahan pokok, bawang merah memiliki beragam manfaat mulai dari bumbu masakan hingga produksi obat herbal. Karena manfaat dan kebutuhan yang beragam inilah membuat tingkat konsumsi bawang merah di Indonesia tinggi. Namun produksi belum mampu memenuhi kebutuhan pasar. Tujuan dari penelitian ini ialah mendapatkan komposisi media tanam yang tepat untuk pertumbuhan dan hasil tanaman bawang merah varietas Bauji. Penelitian ini dilaksanakan pada bulan Maret sampai Mei 2021 di Kelurahan Cinambo, Kecamatan Cisaranten Wetan, Kota Bandung, Jawa Barat dengan menggunakan Rancangan Acak Kelompok non Faktorial dengan 3 kali pengulangan. Terdapat 10 perlakuan kombinasi media tanam ialah P1 = Media tanah : pupuk kandang kambing : pasir (1 : 2 : 1) P2 = Media tanah : pupuk kandang kambing : pasir (1 : 1 : 2) P3 = Media tanah : pupuk kandang kambing : pasir (1 : 1 : 1) P4 = Media tanah : pupuk kandang kambing : pasir (2 : 1 : 1) P5 = Media tanah : pupuk kandang kambing : pasir (2 : 2 : 1) P6 = Media tanah : pupuk kandang sapi : pasir (1 : 2 : 1) P7= Media tanah : pupuk kandang sapi : pasir (1 : 1 : 2) P8	= Media tanah : pupuk kandang sapi : pasir (1 : 1: 1) P9 = Media tanah : pupuk kandang sapi : pasir (2 : 1 : 1) P10= Media tanah : pupuk kandang sapi : pasir (2 : 2 : 1). Penelitian dilakukan secara distruktif dan non distruktif. Hasil penelitian menunjukan bahwa perbedaan komposisi media tanam tidak memberikan pengaruh nyata pada pertumbuhan dan hasil tanaman bawang merah kecuali pada luas daun. Hal ini dapat dimungkinkan bahwa varietas Bauji lebih sesuai dibudidayakan di daerah dataran rendah sampai dataran sedang.
IN VITRO ANTICANCER, ANTIOXIDANT AND MOLECULAR DOCKING STUDIES OF 4-AMINOBENZAMIDE METAL COMPLEXES
Authors: NARASIMHAVARMAN S. , RAJASEKAR K. , MANDAL SUDIP KUMAR , SELVARANI R. , VEERAVEL C. 
Published: August 2022

Objective: Mixed ligand complexes of Cu(II) and Cd(II) with 4-aminobenzamide(4-ABZ) have been synthesized under microwave irradiation and they were characterized by elemental analysis, estimation of metal ion, molar conductivity, magnetic study, FT-IR, Far-IR, electronic spectra, NMR (1H and 13C) and EPR spectral studies.
Methods: The data of microanalysis and metal estimation showed that the complexes have the composition of [M(L1)2(L2)2] for Cu(II) and [M(L1)(L2)2] for Cd(II) complex respectively. The conductivity data confirmed the neutral nature of the complexes. The tetrahedral geometry of the Cd(II) complex was confirmed using UV-Visible spectra. The tetragonally distorted octahedral stereochemistry of Cu(II) complex was further confirmed by UV and EPR spectral studies. The diamagnetic nature and probable geometry of Cd(II) complex were also confirmed using NMR spectral studies, which are also compared with free 4-aminobenzamide. The in vitro bio-potential activities of 4-ABA and Cd(II) complex were screened for E. coli and C. Albicans microorganisms by Agar disc diffusion methods.
Results: The cancer study of Cu(II) complex and antioxidant activity of DPPH free radical scavenging method of Cd(II) complex were measured and compared with 4-aminobenzamide and standard drugs. The breast cancer studies were also identified using the targeted proteins viz., BRCA1, PR and EGFR by molecular docking study.
Conclusion: In the present study, we synthesized new metal complexes of Cu(II) and Cd(II) with 4-ABA and nitrite ion by microwave irradiation method. The analytical data show that the metal-ligand stoichiometry they are non-electrolytes in acetonitrile solution. The spectral data show that the synthesized ligand binds with metal ions through the nitrogen atom of the 4-ABA and oxygen atoms of the nitrite ion.
DEVELOPMENT AND IN VITRO EVALUATION OF VALSARTAN-LOADED RESEALED ERYTHROCYTES
Authors: ELHASSAN GAMAL OSMAN , MOHAMED JAMAL MOIDEEN MUTHU 
Published: August 2022

Objective: Resealed erythrocyte technique has attempts for preparation of valsartan loaded reservoir type using red blood cell as a carrier.
Methods: The resealed erythrocytes were prepared by using glutaraldehyde as a cross-linking agent by Preswell dilution technique and sodium chloride as the medium has been made to predict mechanism of drug release and absorption based on the order of release. The prepared resealed erythrocytes was characterised as a percentage of cell recovery drug content, osmotic shock, turbulence fragility, osmotic fragility, in vitro drug release studies, and hemoglobin content study.
Results: The result of the study showed that the resealed erythrocytes prepared with sodium chloride (9 %) showed biconcave shape, an assay of 6.5±0.4 %, osmotic shock (0.028±0.004 µg/ml), turbulence fragility of 0.228±0.046 µg/ml, and 44.38±5.54 % drug release in 8 h. The drug release kinetics was studied and found that release from spherical matrices, first-order model with non-fickian diffusion with and the dissolution occurs in planes that are parallel to the drug surface pattern.
Conclusion: VaL administration could be avoided the number of drawbacks associated with systemic delivery and perhaps maintain a relatively constant plasma level during a lengthy course of treatment.
Clinical Experience with a Power Injectable Arm Port
Authors: Wright Matthew , Dhaliwal Navraj , Le Ho , Burbridge Brent 
Published: August 2022

Highlights

Abstract

Background:
Totally implanted venous access devices, or ports, are safe and durable, allowing for long-term venous access. Port insertion in the upper extremity is associated with high rates of technical success and few complications. This retrospective review evaluates complication rates of power injectable ports in the upper arm preformed at a tertiary academic institution.

Methods:
A single center retrospective review of all patients undergoing arm port implantation between October 1, 2017, and January 30, 2019, were included. A minimum of 11 months of data was reviewed for each subject. A total of 165 subjects were initially enrolled.

Results:
The most frequent indication for port insertion was malignancy (n = 157). Port insertion technical success rate was 99.4%. There was no significant difference in port-related complications by gender, malignancy, clinical indication for placement, or arm used for implantation. Rates of infection (5.5%), mechanical malfunction (6.7%), device removal (10%) and arterial injury (0%) were similar to previously reported values. The rate of port-related venous thrombosis was 8.6%, exceeding previously reported values.

Conclusion:
Venous thrombosis was increased using this arm port. The polyurethane catheter material may play a role in this. Further work is warranted to investigate venous thrombosis for this device that incorporates information about insertion vein size and insertion vein characteristics.
PENGARUH SUBSTITUSI A. microphylla TERHADAP BOBOT KARKAS, PERSENTASE LEMAK ABDOMEN, BOBOT GIZZARD DAN PANJANG USUS BROILER
Authors: Rahma Wilda , Sutrisna Rudy , Santosa Purnama Edy , Fathul Farida 
Published: August 2022

This study aimed to determine the best percentage of A. microphylla flour on carcass weight, abdominal fat percentage, gizzard weight and intestine length of broiler. This research was conducted in March--April 2021 at PT. Sinar Ternak Sejahtera farm 5 in Wonodadi Village, South Lampung Regency, Lampung Province. Carcass processing was carried out at the Livestock Production Laboratory in the Department of Animal Husbandry, Faculty of Agriculture, University of Lampung. The experimental design used was a completely randomized design (CRD) with 4 treatments and 3 replications. The treatments were basal ration (P0), basal ration with substitution of A. microphylla 2.5% (P1), basal ration with substitution of 5% A. micophylla (P2), and basal ration with substitution of A. microphylla 7.5% (P3). The data obtained were analyzed using analysis of variance with a significance level of 5% and continued with Duncan's Multiple Range test. The results showed that the substitution of A. microphylla on carcass weight and percentage of abdominal fat had a significant effect (P<0.05) and had no significant effect (P>0.05) on gizzard weight and intestine length of broiler.

Keywords: A. microphylla, Carcass weight, Abdominal fat percentage, Gizzard weight, Intestinal length
KUALITAS SUSU SAPI SEGAR PADA PEMERAHAN PAGI DAN SORE
Authors: Wiranti Nevia , Wanniatie Veronica , Husni Ali , Qisthon Arif 
Published: August 2022

This study aims to determine the effect of milking time on the quality of fresh cow's milk. This research was carried out on June 2021, at Neang Mukti Ranch, Air Naningan District, Tanggamus Regency and at Mulia Farm Sukabanjar, Gedong Tataan District, Pesawaran Regency, Lampung. The research material used 7 liters of fresh cow's milk. The morning and evening milking data were obtained from the sum of the mean and standard deviation. The observed variables were alcohol, specific gravity, and reductase tests. This research was analyzed descriptively. The results showed that the morning and evening milking did not show any difference to the alcohol, specific gravity, and reductase tests.
PENGARUH PEMBERIAN Lactobacillus acidophilus TERHADAP pH DAN DAYA IKAT AIR DAGING BROILER
Authors: Solehah Mar’atus , Riyanti RR , Wanniatie Veronica , Septinova Dian 
Published: August 2022

This research aimed to (1) determine the effect of giving Lactobacillus acidophilus on pH and water holding capacity of broiler meat and (2) to determine the best concentration of Lactobacillus acidophilus on pH and water holding capacity of broiler meat. This research was carried out in September 2021 at the Animal Production Laboratory of the Animal Husbandry Department, University of Lampung and the Agricultural Product Technology Laboratory of Food Technology Department of the Lampung State Polytechnic. The research material used were 20 broiler chicken breast fillets. This study used a completely randomized design (CRD) with 4 treatments and 5 replications, namely without the addition of starter Lactobacillus acidophilus (P0), adding 5% starter Lactobacillus acidophilus (P1), adding 10% starter Lactobacillus acidophilus (P2), and adding 15% starter Lactobacillus acidophilus (P3). The observed variables were pH and water holding capacity. Data on pH and water holding capacity were analyzed using Analysis of Variance (ANOVA), and if the results obtained were significantly different, then followed by the Least Significant Difference Test (LSD). The results showed that the use of Lactobacillus acidophilus with concentrations of 5%, 10%, and 15% had a significant effect (P<0.05) on decreasing pH, but it had no significant effect (P>0.05) on water holding capacity. The best concentration of Lactobacillus acidophilus for pH value and water holding capacity was found in sample P3 with a concentration of 15% Lactobacillus acidophilus.

Keywords: Lactobacillus acidophilus, preservation, pH, water holding capacity
KUALITAS FISIK SUSU KAMBING PERAH YANG DISUPLEMENTASI DENGAN SOYBEAN MEAL (SBM)
Authors: Huwaida Safira , Muhtarudin Muhtarudin , Qisthon Arif , Liman Liman 
Published: August 2022

The study aimed to determine the effect of soybean meal supplementation in the ration on physical quality, namely specific gravity, pH, reductase, and dairy goat milk alcohol tests. The research was conducted from July to Agust 2021 at the Telaga Rizky Ranch owned by Mr. Setiono Heri Winarko, Yosodadi Village, East Metro District, Metro city. The samples used in this study were 12 Sapera goats that were lactating and grouped based on body weight. This study used a randomized block design (RBD) method with 4 treatments and 3 replication, namely P0 (control), P1 (soybean meal 5%), P2 (soybean meal 10%), P3 (soybean meal 15%). The data obtained were than analyzed by variance (ANOVA). The results showed that there was no significant effect (P>0.05) of the treatment on the physical test of diary goats’s milk supplemented with soybean meal. The result showed that the physical test of milk, namely for the specific gravity test was 1.0297 g/cm3, pH was 6,8, reductase was 8,0 hours, and alcohol test was negative. The physical quality of Sapera goat’s milk has good quality and is in accordance with the Indonesian Nasional Standard (2011).

Keywords: alcohol, specific gravity, pH, reductase, soybean meal
PENGARUH SUPLEMENTASI TEPUNG KROKOT (Portulaca oleraceae l) DENGAN TARAF YANG BERBEDA TERHADAP KADAR TOTAL PROTEIN PLASMA, ALBUMIN DAN GLOBULIN KAMBING JAWARANDU (Capra aegagrus hircus)
Authors: Setiawan Andi , Siswanto Siswanto , Erwanto Erwanto , Muhtarudin Muhtarudin 
Published: August 2022

This study aimed to determine the best dose of purslane flour on total plasma protein, albumin, and globulin in Jawarandu Goats. This research was conducted in February-March 2021 at the Rambon Asri Farmer Group, Rejo Asri Village, Seputih Raman District, Central Lampung Regency, Lampung Province. Examination of total plasma protein, albumin, and globulin was carried out at the Veterinary Center of Lampung Province. The experimental design used was a completely randomized design (CRD) with 4 treatments and 5 replications. The treatments were basal ration (P0), basal ration with 5% purslane flour supplementation (P1), basal ration with 10% purslane flour supplementation (P2), and basal ration with 15% purslane flour supplementation (P3). The data obtained were analyzed using analysis of variance with a significance level of 5%. The results showed that purslane flour supplementation had no significant effect (P>0.05) on total plasma protein, albumin, and blood globulin of Jawarandu Goats but remained in the normal range.

Keywords : Albumi, Globulin, Jawarandu goat, Purslane flour, Total plasma protein