bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fluid mixing optimization with reinforcement learning
Authors: Konishi Mikito , Inubushi Masanobu , Goto Susumu 
Published: August 2022

AbstractFluid mixing is crucial in various industrial processes. In this study, focusing on the characteristics that reinforcement learning (RL) is suitable for global-in-time optimization, we propose utilizing RL for fluid mixing optimization of passive scalar fields. For the two-dimensional fluid mixing problem described by the advection–diffusion equations, a trained mixer realizes an exponentially fast mixing without any prior knowledge. The stretching and folding by the trained mixer around stagnation points are essential in the optimal mixing process. Furthermore, this study introduces a physically reasonable transfer learning method of the trained mixer: reusing a mixer trained at a certain Péclet number to the mixing problem at another Péclet number. Based on the optimization results of the laminar mixing, we discuss applications of the proposed method to industrial mixing problems, including turbulent mixing.
Numerical methodology to evaluate unipolar saturation current limit of DC corona discharge in complex geometries
Authors: Kim Sangwoo , Hwang Jungho 
Published: August 2022

AbstractThe unipolar saturation current limit ($${I}_{sat}$$

I

sat

) gives an upper limit to the corona current that can be obtained from a unipolar corona discharge. Therefore, it implies a theoretical limit to the performance of unipolar corona discharge devices. However, it has not been widely used in practice because it is difficult to deal with complex discharge configurations in an analytical way. This study aims to establish and validate a numerical methodology to evaluate the maximum current, which numerically imitates the unipolar saturation current limit. It was shown that the maximum current has the same mathematical definition as the unipolar saturation current. For validation, the maximum current was compared with an analytical solution of the Poisson equation for the coaxial cylinders configuration. The differences between the maximum current and unipolar saturation current limit for the coaxial cylinders, pin-to-plane, and single wire-to-plane configurations were discussed in terms of the assumptions used in the semi-analytical derivation of the unipolar saturation current limit. The validated methodology was applied to a multiple wire-to-plane configuration, for which a semi-analytical expression of the unipolar saturation current limit has not yet been developed. The effects of geometric and operation parameters on the maximum currents of the multiple wire-to-plane configuration were analyzed. The results were regressed into a single formula.
Lysyl hydroxylase 2 mediated collagen post-translational modifications and functional outcomes
Authors: Terajima Masahiko , Taga Yuki , Nakamura Tomoyuki , Guo Hou-Fu , Kayashima Yukako , Maeda-Smithies Nobuyo , Parag-Sharma Kshitij , Kim Jeong Seon , Amelio Antonio L. , Mizuno Kazunori , Kurie Jonathan M. , Yamauchi Mitsuo 
Published: August 2022

AbstractLysyl hydroxylase 2 (LH2) is a member of LH family that catalyzes the hydroxylation of lysine (Lys) residues on collagen, and this particular isozyme has been implicated in various diseases. While its function as a telopeptidyl LH is generally accepted, several fundamental questions remain unanswered: 1. Does LH2 catalyze the hydroxylation of all telopeptidyl Lys residues of collagen? 2. Is LH2 involved in the helical Lys hydroxylation? 3. What are the functional consequences when LH2 is completely absent? To answer these questions, we generated LH2-null MC3T3 cells (LH2KO), and extensively characterized the type I collagen phenotypes in comparison with controls. Cross-link analysis demonstrated that the hydroxylysine-aldehyde (Hylald)-derived cross-links were completely absent from LH2KO collagen with concomitant increases in the Lysald-derived cross-links. Mass spectrometric analysis revealed that, in LH2KO type I collagen, telopeptidyl Lys hydroxylation was completely abolished at all sites while helical Lys hydroxylation was slightly diminished in a site-specific manner. Moreover, di-glycosylated Hyl was diminished at the expense of mono-glycosylated Hyl. LH2KO collagen was highly soluble and digestible, fibril diameters were diminished, and mineralization impaired when compared to controls. Together, these data underscore the critical role of LH2-catalyzed collagen modifications in collagen stability, organization and mineralization in MC3T3 cells.
Farasan Island of Saudi Arabia confronts the measurable impacts of global warming in 45 years
Authors: Khedher Khaled Mohamed , Abu-Taweel Gasem Mohammad , Al-Fifi Zarraq , Qoradi Mofareh D. , Al-khafaji Zainab , Halder Bijay , Bandyopadhyay Jatisankar , Shahid Shamsuddin , Essaied LAATAR , Yaseen Zaher Mundher 
Published: August 2022

AbstractCoastal vulnerability assessment is the key to coastal management and sustainable development. Sea level rise (SLR) and anthropogenic activities have triggered more extreme climatic events and made the coastal region vulnerable in recent decades. Many parts of the world also noticed increased sediment deposition, tidal effects, and changes in the shoreline. Farasan Island, located in the south-eastern part of Saudi Arabia, experienced changes in sediment deposition from the Red Sea in recent years. This study used Digital Shoreline Analysis System (DSAS) to delineate the shoreline changes of Farasan Island during 1975–2020. Multi-temporal Landsat data and DSAS were used for shoreline calculation based on endpoint rate (EPR) and linear regression. Results revealed an increase in vegetation area on the island by 17.18 km2 during 1975–1989 and then a decrease by 69.85 km2 during 1990–2020. The built-up land increased by 5.69 km2 over the study period to accommodate the population growth. The annual temperature showed an increase at a rate of 0.196 °C/year. The sea-level rise caused a shift in the island's shoreline and caused a reduction of land by 80.86 km2 during 1975–2020. The highly influenced areas by the environmental changes were the north, central, northwest, southwest, and northeast parts of the island. Urban expansion and sea-level rise gradually influence the island ecosystem, which needs proper attention, management, policies, and awareness planning to protect the environment of Farasan Island. Also, the study’s findings could help develop new strategies and plan climate change adaptation.
Personality similarity predicts synchronous neural responses in fMRI and EEG data
Authors: Matz Sandra C. , Hyon Ryan , Baek Elisa C. , Parkinson Carolyn , Cerf Moran 
Published: August 2022

AbstractSuccessful communication and cooperation among different members of society depends, in part, on a consistent understanding of the physical and social world. What drives this alignment in perspectives? We present evidence from two neuroimaging studies using functional magnetic resonance imaging (fMRI;N = 66 with 2145 dyadic comparisons) and electroencephalography (EEG;N = 225 with 25,200 dyadic comparisons) to show that: (1) the extent to which people’s neural responses are synchronized when viewing naturalistic stimuli is related to their personality profiles, and (2) that this effect is stronger than that of similarity in gender, ethnicity and political affiliation. The localization of the fMRI results in combination with the additional eye tracking analyses suggest that the relationship between personality similarity and neural synchrony likely reflects alignment in the interpretation of stimuli and not alignment in overt visual attention. Together, the findings suggest that similarity in psychological dispositions aligns people’s reality via shared interpretations of the external world.
Experimental and modeling investigation of organic modified montmorillonite with octyl quaternary ammonium salt
Authors: Liu Hongyan , Guo Chengxin , Cui Yingna , Yin Jingmei , Li Shenmin 
Published: August 2022

AbstractThe sodium montmorillonite was organic modified with three kinds of quaternary ammonium salts containing 1 to 3 octyl chains, and then the organic montmorillonite was studied by FT-IR, XRD, and TG characterization as well as Monte Carlo simulations, to explore the influence of the number of octyl chains and the loading of intercalated cations on the basal spacing (d001) of the modified montmorillonite complexes. According to the distribution of intercalated quaternary ammonium cations and the energy change of the montmorillonite complexes, a reasonable explanation was given for the enlargement of the interlayer space. The results of experimental characterization and Monte Carlo simulations show that all the three intercalation agents can enlarge the interlayer space of montmorillonite complexes. The more the number of octyl chains in the salt, the more significant expanding effect on the interlayer space. The three intercalation cations exhibited a distribution arranged from mono-layered to multi-layered structure as the loading of intercalated cations increases.
New putative phenol oxidase in ascidian blood cells
Authors: Daugavet M. A. , Dobrynina M. I. , Shaposhnikova T. G. , Solovyeva A. I. , Mittenberg A. G. , Shabelnikov S. V. , Babkina I. Yu. , Grinchenko A. V. , Ilyaskina D. V. , Podgornaya O. I. 
Published: August 2022

AbstractThe phenol oxidase system is ancient and ubiquitously distributed in all living organisms. In various groups it serves for the biosynthesis of pigments and neurotransmitters (dopamine), defence reactions and tissue hardening. Ascidians belong to subphylum Tunicata, which is considered the closest living relative to Vertebrates. Two phenol oxidases previously described for ascidians are vertebrate-like and arthropod-like phenol oxidases. In our present study, we described a new ascidian protein, Tuphoxin, with putative phenol oxidase function, which bears no sequence similarity with two enzymes described previously. The closest related proteins to Tuphoxin are mollusc haemocyanins. Unlike haemocyanins, which are oxygen transporting plasma proteins, Tuphoxin is synthesised in ascidian blood cells and secreted in the extracellular matrix of the tunic—ascidian outer coverings. Single mature transcript coding for this phenol oxidase can give several protein products of different sizes. Thus limited proteolysis of the initial protein is suggested. A unique feature of Tuphoxins and their homologues among Tunicata is the presence of thrombospondin first type repeats (TSP1) domain in their sequence which is supposed to provide interaction with extracellular matrix. The finding of TSP1 in the structure of phenol oxidases is new and we consider this to be an innovation of Tunicata evolutionary lineage.
Loureirin B downregulates osteoclast differentiation of bone marrow macrophages by targeting the MAPK signaling pathway
Authors: Zhang Jiahao , Mo Liang , Huang Haoran , Xu Jiake , Fan Yinuo , Li Weifeng , Wang Haibin , Zhou Chi , Fang Hanjun , He Wei , Chen Zhenqiu , Liu Yuhao 
Published: August 2022

AbstractExcessive absorption of osteoclasts will break the balance between osteoclasts and osteoblasts, leading to bone loss, decreased bone density, and increased bone fragility. We have shown that Loureirin B (LrB) can inhibit osteoclasts. In this study, we demonstrated the targeting-inhibitory mechanism of LrB acting on osteoclast precursor. Using SPR, HPLC and MALDI-TOF-MS to capture and analyze the target protein of Loureirin B in bone marrow macrophages (BMMs), we used this method to detect all target proteins that LrB acts on BMMs, and analyzed the distribution and enrichment rate of the target protein by DAVID enrichment analysis. Ledock molecular docking was used to detect the binding of LrB. We used Western Blot for verification. The target proteins of LrB acting on BMMs were Serpine1, Atp6ap1, Dvl1, Rhd, Fzd2, MAPK1, MAP2K2, MAPK3 and so on. MAPK1, MAP2K2 and MAPK3 were the most relevant. LrB treatment attenuated the expression of phosphorylated JNK and p38 kinases of the MAPK signaling pathway. Our research further confirmed that LrB affects the MAPK signaling pathway in BMMs, thereby inhibiting the differentiation of BMMs into osteoclasts. This discovery can confirm the mechanism by which LrB acts on BMMs.
A study on synergistic effect of chloride and sulfate ions on copper corrosion by using electrochemical noise in asymmetric cells
Authors: Sajadi Ghazal Sadat , Saheb Vahid , Shahidi-Zandi Mehdi , Hosseini Seyed Mohammad Ali 
Published: August 2022

AbstractThe current study includes a systematic examination of copper corrosion initially in each of NaCl and Na2SO4solutions separately and then in the mixture solution of Cl−and SO42−ions as aggressive ions. Electrochemical current noise (ECN) signals resulting from asymmetric (Asy) as well as symmetric (Sym) cells have been interpreted using wavelet transform (WT) along with statistical procedures. The signals have been detrended and the decomposition of every signal has been carried out into 8 crystals. Then the standard deviation of every crystal has been illustrated with the standard deviation of partial signal (SDPS) plots. The Asy electrodes increased the pitting detection on copper compared with the Sym ones, indicating higher efficiency of the Asy electrodes. Asymmetric-copper electrodes have been studied using SDPS plots at different temperatures (40, 60, as well as 80 °C). Finally, in order to partly understand the effect of Cl−and SO42−ions on the corrosion of copper, the stabilization of Cu2+cations by Cl−and SO42−ions in aqueous solutions have been modeled by DFT calculations. The derived results are in accordance with the experimental data.
Correlations between APOE4 allele and regional amyloid and tau burdens in cognitively normal older individuals
Authors: Hong Yun Jeong , Kim Chan-Mi , Lee Jae Hong , Sepulcre Jorge 
Published: August 2022

AbstractThe correlations between apolipoprotein epsilon 4 (APOE4) status and regional amyloid, tau, and cortical thickness in cognitively normal elderly are not fully understood. Our cross-sectional study aimed to compare regional amyloid/tau burden, and cortical thickness according to APOE4 carrier status and assess correlations between APOE4 and Alzheimer’s disease (AD)-related biomarker burdens. We analyzed 185 cognitively normal participants from the Alzheimer’s Disease Neuroimaging Initiative (ADNI) cohort. Participants aged 55–90 with normal cognitive function were divided into amyloid ß-positive (Aß+) APOE4 carriers (group 1, n = 27), Aß+ APOE4 non-carriers (group 2, n = 29), and Aß− normal controls (group 0, n = 129). We compared amyloid depositions, tau depositions, and cortical thickness among the three groups and assessed correlations between APOE4 existence and imaging biomarkers adjusted for age and sex. The participants in group 2 were older than those in the other groups. The regional amyloid/tau standardized uptake value ratios (SUVRs) did not differ between groups 1 and 2, but the amyloid/tau SUVRs in most regions were numerically higher after adjusting for age difference. APOE4 allele had robust correlations with increased amyloid burden in the fronto-temporo-parietal cortical areas after adjustment for age and sex, but it had weaker and mixed correlations with the regional tau burden and did not have significant correlation with cortical thickness. We identified that the presence of APOE4 allele might be more highly associated with amyloid deposition than with other AD-related biomarkers such as tau or cortical thickness in cognitively normal elderly.
Monitoring non-parametric profiles using adaptive EWMA control chart
Authors: Abbasi Saddam Akber , Yeganeh Ali , Shongwe Sandile C. 
Published: August 2022

AbstractTo monitor the quality of a process in statistical process control (SPC), considering a functional relationship between a dependent variable and one or more independent variables (which is denoted as profile monitoring) is becoming an increasingly common approach. Most of the studies in the SPC literature considered parametric approaches in which the functional relationship has the same form in the in-control (IC) and out-of-control (OC) situations. Non-parametric profiles, which have a different functional relationship in the OC conditions are very common. This paper designs a novel control chart to monitor not only the regression parameters but also the variation of the profiles in Phase II applications using an adaptive approach. Adaptive control charts adjust the final statistic with regard to information of the previous samples. The proposed method considers the relative distance of the chart statistic to the control limits as a tendency index and provides some outcomes about the process condition. The results of Monte Carlo simulations show the superiority of the proposed monitoring scheme in comparison with the common non-parametric control charts.
Dicationic styryl dyes for colorimetric and fluorescent detection of nucleic acids
Authors: Supabowornsathit Kotchakorn , Faikhruea Kriangsak , Ditmangklo Boonsong , Jaroenchuensiri Theeranuch , Wongsuwan Sutthida , Junpra-ob Sirikarn , Choopara Ilada , Palaga Tanapat , Aonbangkhen Chanat , Somboonna Naraporn , Taechalertpaisarn Jaru , Vilaivan Tirayut 
Published: August 2022

AbstractNucleic acid staining dyes are important tools for the analysis and visualizing of DNA/RNA in vitro and in the cells. Nevertheless, the range of commercially accessible dyes is still rather limited, and they are often very costly. As a result, finding nontoxic, easily accessible dyes, with desirable optical characteristics remains important. Styryl dyes have recently gained popularity as potential biological staining agents with many appealing properties, including a straightforward synthesis procedure, excellent photostability, tunable fluorescence, and high fluorescence quantum yield in the presence of nucleic acid targets with low background fluorescence signals. In addition to fluorescence, styryl dyes are strongly colored and exhibit solvatochromic properties which make them useful as colorimetric stains for low-cost and rapid testing of nucleic acids. In this work, novel dicationic styryl dyes bearing quaternary ammonium groups are designed to improve binding strength and optical response with target nucleic acids which contain a negatively charged phosphate backbone. Optical properties of the newly synthesized styryl dyes have been studied in the presence and absence of nucleic acid targets with the aim to find new dyes that can sensitively and specifically change fluorescence and/or color in the presence of nucleic acid targets. The binding interaction and optical response of the dicationic styryl dyes with nucleic acid were superior to the corresponding monocationic styryl dyes. Applications of the developed dyes for colorimetric detection of DNA in vitro and imaging of cellular nucleic acids are also demonstrated.
Stable isotopes provide evidence that condensed tannins from sericea lespedeza are degraded by ruminal microbes
Authors: O. S. van Cleef Flavia , B. Dubeux José C. , Wheeler Chrisee S. , V. García Carlos C. , Ruiz-Moreno Martin , Sollenberger Lynn E. , B. Vendramini João M. , DiLorenzo Nicolas , Naumann Harley D. 
Published: August 2022

AbstractThe objective of Trial 1 was to determine the effects of condensed tannins (CT) from sericea lespedeza [SL; Lespedeza cuneata (Dum. Cours.) G. Don] on in vitro digestible organic matter (IVDOM), total gas production (GP), methane (CH4) emission, and ruminal fluid parameters after fermentation. Substrates used in four 48-h in vitro fermentations were 100% bermudagrass [(Cynodon dactylon (L.) Pers.] hay (0SL), 100% SL hay (100SL), and a mix of both hays (50SL). Linear reductions were observed for all parameters (P < 0.05) with the inclusion of SL, except for CH4 in relation to GP, that presented a quadratic effect (P = 0.005). In Trial 2, SL plants were enriched with 13C–CO2 to obtain pure enriched CT to identify the destination of fermentation end products of CT degradation. The enrichment of CT through the SL was successful (P < 0.001), and carbon originated from CT was detected in the fermentation end products [microbial mass, clarified rumen fluid, and in the CH4 produced (P < 0.001)]. Therefore, inclusion of SL was effective in reducing in vitro CH4 production and compound-specific tracing of δ13C abundance provided better quantitative understanding of the mechanisms of partitioning CT during ruminal fermentation processes.
Modified method of patency judgement using patency capsule prior to capsule endoscopy in clinical practice
Authors: Miyazu Takahiro , Osawa Satoshi , Tamura Satoshi , Tani Shinya , Ishida Natsuki , Matsuura Tomoharu , Yamade Mihoko , Iwaizumi Moriya , Hamaya Yasushi , Furuta Takahisa , Sugimoto Ken 
Published: August 2022

AbstractIn 2012, Japan approved the use of a tag-less patency capsule (PC), which evaluates gastrointestinal patency before small-bowel capsule endoscopy (SBCE). This study aimed to evaluate the validity of our modification on the passage criteria for this PC in clinical practice. We retrospectively enrolled 326 consecutive patients who underwent PC examination before SBCE. If X-ray could not reveal the PC in the body during the judgement time (30–33 h after ingestion), we defined it as ‘estimated patency’ and performed SBCE. We employed plain computed tomography (CT) for the second judgement, as needed. The overall patency rate was 95.1%. By X-ray, 41 (12.6%) patients were judged to have ‘estimated patency’, and SBCE could be safely performed. Plain CT judgement was necessary in 106 patients (32.5%). One PC case had a residual coating film associated with stenosis in a patient with Crohn’s disease (CD), and one (0.3%) SBCE case had capsule retention resulting from false CT judgement. Multivariate analysis revealed that established CD and inpatient were factors related to no-patency. In conclusion, PC is useful for examining gastrointestinal patency, keeping in mind CT misjudgement. If PC was not found in the body via X-ray, performing SBCE as ‘estimated patency’ seemed appropriate.