bluuebunny/crossref_metadata_2025_split huggingface dataset:
Disparities in Outcomes Among Patients Diagnosed With Cancer in Proximity to an Emergency Department Visit
Authors: Pettit Nicholas , Sarmiento Elisa , Kline Jeffrey 
Published: January 2022

Abstract
A suspected diagnosis of cancer in the emergency department (ED) may be associated with poor outcomes, related to health disparities, however data are limited. This study is a case-control analysis of the Indiana State Department of Health Cancer Registry, and the Indiana Network for Patient Care. First time cancer diagnoses appearing in the registry between January 2013 and December 2017 were included. Cases were patients who had an ED visit in the 6 months before their cancer diagnosis; controls had no recent ED visits. The primary outcome was mortality, comparing ED-associated mortality to non-ED-associated. 134,761 first-time cancer patients were identified, including 15,432 (11.5%) cases. The mean age was same at 65, more of the cases were Black than the controls (12.4% vs 7.4%, P<.0001) and more were low income (36.4%. vs 29.3%). The top 3 ED-associated cancer diagnoses were lung (18.4%), breast (8.9%), and colorectal cancers (8.9%), whereas the controls were breast (17%), lung (14.9%), and prostate cancers (10.1%). Cases observed an over three-fold higher mortality, with cumulative death rate of 32.9% for cases vs 9.0% for controls (P<.0001). Regression analysis predicting mortality, controlling for many confounders produced an odds ratio of 4.12 (95% CI 3.72-4.56 for cases). This study found that an ED visit within 6 months prior to the first time of ICD-coded cancer is associated with Black race, low income and an overall three-fold increased adjusted risk of death. The mortality rates for ED-associated cancers are uniformly worse for all cancer types. These data suggest that additional work is needed to reduce disparities among ED-associated cancer diagnoses.
A Practical Underwater Information Sensing System Based on Intermittent Chaos Under the Background of Lévy Noise
Authors: Zhang Hanwen , Qin Zhen , Zhang Yichao , Chen Dajiang , Gen Ji , Qin Hao 
Published: January 2022

Abstract
The Gaussian noise model has been chosen for underwater information sensing tasks under substantial interference for most of the research at present. However, it often contains a strong impact and does not conform to the Gaussian distribution. In this paper, a practical underwater information sensing system is proposed based on intermittent chaos under the background of Lévy noise. In this system, a novel Lévy noise model is presented to describe the underwater natural environment interference and estimate its parameters, which can better describe the impact characteristics of the underwater environment. Then an underwater environment sensing method of dual-coupled intermittent chaotic Duffing oscillator is improved by using the variable step-size method and scale transformation. The simulation results show that the method can sense weak signals and estimate their frequencies under the background of strong Lévy noise, and the estimation error is as low as 0.03%. Compared with the intermittent chaos of the single Duffing oscillator and the intermittent chaotic Duffing of double coupling, the minimum SNR ratio threshold has been reduced by 11.5dB and 6.9dB, respectively, and the computational cost significantly reduced, and the sensing efficiency is significantly improved.
Compatibility of indigenous isolates HR1, HR2 of entomopathogenic nematodes, with low-toxicity insecticides for control of fall armyworm, Spodoptera frugiperda (J.E. Smith) (Lepidoptera: Noctuidae) and tomato leafminer, Tuta absoluta (Meyrick) (Lepidoptera: Gelechiidae)
Authors: Kasi Indra Kumar , Singh Mohinder , Waiba Kanchhi Maya 
Published: January 2022

Abstract
Invasive species are a major danger to agronomic and natural ecosystems, and due to environmental concerns about pesticide use, EPNs have the potential to replace larvicidal action in pest management. The goal was to see how well local isolates of Steinernema feltiae (HR1) and Heterorhabditis bacteriophora (HR2) controlled invasive species when combined with low-toxicity pesticides. HR1 + Spinosad, chlorantraniliprole produced over 90% mortality in larvae at 96 hours, while HR2 + Spinosad, chlorantraniliprole caused over 95% mortality at 96 hours. After treatment, the high dose was regarded the least hazardous technique for controlling fall armyworm. At the high dose, HR1 + Spinosad, chlorantraniliprole produced larvae death of over 100 percent at 96 hours, and HR2 + Spinosad, chlorantraniliprole caused mortality of over 97.50 percent at 96 hours, and should be considered as a least hazardous strategy for T. absoluta management. Controlling larvae mortality of above 100% at 96 hours in combination with low-toxicity insecticide dosages should be included as a least harmful technique to control T. absoluta. The results showed that these HR2 strains have high pathogenicity against T. absoluta and S. frugiperda and have potential for control in integrated approaches, causing 100 percent and 90.00 percent mortality of T. absoluta and S. frugiperda at 96 hours at the high dose as a least toxic strategy to control.
Lambs Fed Diets Containing By-Product from Coconut Processing: Histomorphometry Characteristics in the Digestive and Renal Systems
Authors: Silva Felipe José Santos da , Júnior Dorgival Morais de Lima , Guerra Ricardo Romão , de Almeida Vitor Visintin Silva , Ribeiro Julimar do Sacramento , Fernandes Beatriz Dantas Oliveira , Souza Anaiane Pereira , de Medeiros Ariosvaldo Nunes 
Published: January 2022

Abstract
This study aimed to evaluate the histological characteristics in the digestive and renal systems of lambs fed diets containing coconut by-product (CB). A total of 35 male lambs with an initial weight of 16.9 ± 2.93 kg were distributed in a completely randomized design with five levels of CB in the diet (0; 4.8; 9.6; 14.4 and 19.2% in total dry matter). Samples of the liver, kidney, rumen, and intestine were histomorphometrically evaluated and the data were submitted to regression analysis, at a 5% error probability. The inclusion of CB linearly decreased the dry matter intake and caused a quadratic effect for the height of ruminal papillae, absorption area, epithelium thickness, as well as for average daily gain. The inclusion of CB linearly increased the mucous layer and reduced the submucosal layer, as well as promoted a decrease in goblet cells in the small intestine. The inclusion of BC did not influence hepatic glycogen, additionally, the histopathological examination did not reveal liver damage or congestion, vacuolization, and necrosis of the renal tissue. Therefore, our results indicate that CB can be included in lambs diet up to the level of 7.2% without causing changes in the histomorphometry characteristics of the gastrointestinal tract and changes in liver and kidney tissue that compromise animal performance.
Elastic Material Damage of Rotational Atherectomy and Orbital Atherectomy: An in Vitro Assessment
Authors: Higami Hirooki , Kashima Yoshifumi , Yokoi Kensuke , Nomura Shinnosuke , Tateyama Hikaru , Kaitani Kazuaki 
Published: January 2022

Abstract
PurposeRotational atherectomy (RA) and orbital atherectomy (OA) are effective procedures for severe calcified coronary artery disease. Nonetheless, vessel perforation remains an adverse complication of these procedures. This study aimed to evaluate factors affecting elastic material damage caused by RA and OA.MethodsAn in vitro assessment was conducted in which the damage to the rubber latex, an elastic material, after RA was evaluated under various conditions, including burr rotational speed (100,000–220,000 rotations per minute), approaching curve, burr size (1.25 mm, 1.75 mm, and 2.0 mm), and fluid viscosity (water and low-molecular weight dextran). Similarly, the rubber latex damage after OA was evaluated in the same experimental system under various conditions, including crown rotational speed, approaching curve, and fluid viscosity.ResultsIn RA, the rubber latex was damaged at lower rotational speeds (p = 0.003), tighter approaching curves (p < 0.0001), and lower fluid viscosity (p = 0.03). In OA, the rubber latex was generally severely damaged.ConclusionA higher rotational speed, coaxial approach for the wall, and higher viscosity contributed to lesser elastic material damage in RA. The safety mechanism for elastic material in OA proved less effective.
Role of Sub-Silicone Oil Application of Triamcinolone Acetonide (TA) Drops on Outcomes After 360° Relaxing Retinectomy in Extreme Proliferative Vitreoretinopathy Cases- A Pilot Study.
Authors: Boral Subhendu Kumar , Agarwal Deepak , Das Arnab , Chakraborty Debdulal 
Published: January 2022

Abstract
Purpose: To perform a pilot study to evaluate the role of sub-silicone oil Triamcinolone Acetonide (TA) crystal drops in complex Retinal Detachment (RD) with extreme proliferative vitreoretinopathy (PVR) requiring 360-degree relaxing retinectomy (RR). Design: It was a retrospective pilot studyMaterials & methods : It was a retrospective, case-control pilot study. TA assisted 23G or 25G vitrectomy was done in 24 complex RDs with extreme PVR where 360 degree RR had to be performed. Group A (n=13) included cases where additional TA crystal drops were applied, after settling the detached retina, over the site of RR under silicone oil (SO 5000 cSt) tamponade. In control arm, group B (n=11), additional TA crystals were not applied. Main outcomes measured : Mean pre and post operative BCVA, ultra-widefield retinograph by Optos 200Tx, macular OCT and the propensity to remove silicone oil were measured. Results: Mean preoperative and postoperative BCVA at final follow up were Log MAR 2.69 (20/9795) ± 0.41 and Log MAR 1.51 (20/647) ±0.90 (p<0.05) respectively in Group A and Log MAR 2.9 (20/15886) and Log MAR 2.37 (20/4688) ±0.86 (p<0.05) respectively in group B. Visual improvement in group A was significantly better than group B (two-sample t-test, p<0.05) with significantly less recurrence of RD (Fisher’s Exact Test, p=0.002). Silicone oil removal was done significantly more in group A (Fisher’s Exact Test, p=0.0017). Conclusion: Sub-silicone oil TA crystals application over sites of RR after 360-degree relaxing retinectomy leads to improved postoperative visual recovery as well as improved anatomical outcomes with fewer complications.
Can Status Inequality Organize Cooperation in Multi-leader Systems? An Evolutionary Theory
Authors: Lee Hsuan-Wei , Chang Yen-Ping , Chiang Yen-Sheng 
Published: January 2022

Abstract
Status hierarchies often emerge in small collective task groups. In these groups, clearly defined hierarchies facilitate and stabilize structured cooperative interactions among group members, supporting their evolutionary function in the real world. What the existing research in this field has failed to consider, however, is that cooperation matters in these hierarchies with clear status inequality, as well as in other more realistic, multiple-leader groups with less clear hierarchies. Multi-leadership is ubiquitous but, by definition, flattens status inequality and may, in turn, jeopardize its capacity to sustain cooperation. Leveraging the relationship between multi-leadership and cooperation, our evolutionary game model reveals that hierarchies, in general, promote cooperation in groups with multiple leaders, but these hierarchies only do that up to a point, after which multi-leadership backfires. Accordingly, the model provides not only a theoretical account for how multi-leadership coexists with cooperation but also the conditions under which the coexistence would break.
Characterization and Complete Genome Analysis of a Novel Escherichia Phage, vB_EcoM-RPN242
Authors: Imklin Napakhwan , Sripras Pattaraporn , Thanantong Narut , Lekcharoensuk Porntippa , Nasanit Rujikan 
Published: January 2022

Abstract
The novel Escherichia phage vB_EcoM-RPN242 was isolated using a strain of Escherichia coli host originated from a diarrheal piglet. The phage was able to form plaques on the E. coli lawn at 15−45ºC. Moreover, it was stable over a wide pH (4−10) and temperature (4−70ºC) range. The vB_EcoM-RPN242 genome was found to be a linear, double-stranded DNA consisting of 154,840 base pairs. There were 195 protein-encoding genes and 2 tRNAs detected in the genome, however no unfavorable gene was found. According to the overall nucleotide sequence comparison, the vB_EcoM-RPN242 possibly represents a new phage species in the genus Agtrevirus.
Incidence and Predictors of Cerebral Salt Wasting Syndrome in Stroke Patients – Results of a Prospective Observational Study
Authors: Ranasinghe Vindya Shalini , Bowatte Gayan , Antonypillai Charles , Gawarammana Indika Bandara 
Published: January 2022

Abstract
BackgroundCerebral salt wasting syndrome (CSWS) and Syndrome of Inappropriate Anti Diuretic Hormone secretion (SIADH) are the most common aetiological factors for developing hyponatremia following stroke. The differentiation of these two entities is crucial as the treatment options are completely different. Hence the knowledge on predictors of CSWS is important to make a more accurate diagnosis of CSWS. MethodsTwo hundred and fourty six patients with confirmed stroke were prospectively observed throughout the hospital stay in a tertiary referral center in Sri Lanka to identify the possible predictors of CSWS. Hyponatremia was defined as serum Na+ level less than 131mmo/l. Serum osmolality, urine osmolality, urinary Na+, serum cortisol and thyroid function tests were performed on all the hyponatremic patients. Differentiation of the CSWS and SIADH was based on physical examination findings and laboratory parameters. ResultsThe incidence of hyponatremia in our study population was 19.1% (95% Confidence Interval 14.39-24.58). The majority of patients (24, 51%) were attributed to CSWS. SIADH group comprised of 17 (36.2%) patients and 6 (12.7%) patients had other undetermined causes. There was a significant statistical difference between the aetiologies of hyponatremia and laboratory investigations like urinary Na+, urinary osmolality and serum osmolality. Demographic characteristics, comorbidities, imaging findings and clinical parameters like systolic blood pressure, diastolic blood pressure, on admission GCS were considered in the multivariable logistic regression model and the overall model was not significant. Conclusion The incidence of CSWS is higher than the incidence of SIADH. The demographic characteristics, comorbidities, imaging and clinical parameters like blood pressure, on admission GCS could not predict the occurrence of CSWS
Synthesis, Antibacterial, Thrombolytic and Cytotoxic Evaluation of Substituted and Un-substituted Selenium-n-heterocyclic Carbene Adducts
Authors: Kamal Amna , Iqbal Muhammad Adnan , Bhatti Haq Nawaz , Ghaffar Abdul 
Published: January 2022

Abstract
N-heterocyclic carbene salts bearing alkyl substituents (1-8) and their selenium N-heterocyclic carbene adducts (9-12) were synthesized and characterized by elemental analysis, FT-IR, NMR (1HNMR, 13CNMR) spectroscopic techniques. All the adducts were found to be stable in air and moisture at room temperature. Compounds (5-12) were evaluated against Bacillus subtilis Macrococcus brunensis and Bacillus cereus in vitro. The biological assay revealed that antibacterial activity of Selenium-N-heterocyclic carbene adducts are comparatively better than the salts. MIC and inhibition zone values showed that Bacillus subtilis is more active to selenium adducts (9-12) than Macrococcus brunensis and Bacillus cereus whereas opposite in the salts (5-8). In vitro studies of hemolysis and thrombolysis demonstrated that the synthesized compounds are innocuous for pre-clinical trials to mouse blood.
Nonlinear Tactile Estimation Model based on Perceptibility of Mechanoreceptors improves Quantitative Tactile Sensing
Authors: Sagara Momoko , Nobuyama Lisako , Takemura Kenjiro 
Published: January 2022

Abstract
Tactile sensing has attracted significant attention as a tactile quantitative evaluation method because the tactile sensation is an important factor while evaluating consumer products. While the human tactile perception mechanism has nonlinearity, previous studies have often developed linear regression models. In contrast, this study proposes a nonlinear tactile estimation model that can estimate sensory evaluation scores from physical measurements. We extracted features from the vibration data obtained by a tactile sensor based on the perceptibility of mechanoreceptors. In parallel, a sensory evaluation test was conducted using 10 evaluation words. Then, the relationship between the extracted features and the tactile evaluation results was modeled using linear/nonlinear regressions. The best model was concluded by comparing the mean squared error between the model predictions and the actual values. The result implies that there are multiple evaluation words suitable for adopting nonlinear regression models, and the average error was 43.8% smaller than that of building only linear regression models.
An Optimizing Method for Performance and ResourceUtilization in Quantum Machine Learning Circuits
Authors: Salehi Tahereh , Zomorodi Mariam , Pławiak Paweł , Abbaszade Mina , Salari Vahid 
Published: January 2022

Abstract
Quantum computing is a new and advanced topic that refers to calculations based on the principles of quantum mechanics. Itmakes certain kinds of problems be solved easier compared to classical computers. This advantage of quantum computingcan be used to implement many existing problems in different fields incredibly effectively. One important field that quantumcomputing has shown great results in machine learning. Until now, many different quantum algorithms have been presented toperform different machine learning approaches. In some special cases, the execution time of these quantum algorithms will bereduced exponentially compared to the classical ones. But at the same time, with increasing data volume and computationtime, taking care of systems to prevent unwanted interactions with the environment can be a daunting task and since thesealgorithms work on machine learning problems, which usually includes big data, their implementation is very costly in terms ofquantum resources. Here, in this paper, we have proposed an approach to reduce the cost of quantum circuits and to optimizequantum machine learning circuits in particular. To reduce the number of resources used, in this paper an approach includingdifferent optimization algorithms is considered. Our approach is used to optimize quantum machine learning algorithms forbig data. In this case, the optimized circuits run quantum machine learning algorithms in less time than the original onesand by preserving the original functionality. Our approach improves the number of quantum gates by 10.7% and 14.9% indifferent circuits and the number of time steps is reduced by three and 15 units, respectively. This is the amount of reduction forone iteration of a given sub-circuit U in the main circuit. For cases where this sub-circuit is repeated more times in the maincircuit, the optimization rate is increased. Therefore, by applying the proposed method to circuits with big data, both cost andperformance are improved.
Genomic and Immunological Features of Micropapillary Pattern in Lung Adenocarcinoma
Authors: Huo Yansong , Sun Leina , Yuan Jie , Zhang Hua , Zhang Zhenfa , Zhang Lianmin , Huang Wuhao Huang , Sun Xiaoyan , Tang Zhe , Feng Yingnan , Mo Huilan , Yang Zuoquan , Zhang Chao , Yu Zicheng , Yue Dongsheng , Zhang Bin , Wang Changli 
Published: January 2022

Abstract
Background: Lung adenocarcinoma (LUAD) usually contain heterogeneous histological subtypes, among which the micropapillary (MIP) subtype was associated with poor prognosis while the lepidic (LEP) subtype possessed the most favorable outcome. A more comprehensive analysis involving discovery and public validation cohorts on the two subtypes could better decipher the key biological and evolutionary mechanisms.Methods: We firstly retrospectively studied the survival status of 286 LUAD patients with different subtypes. MIP and LEP components were micro-dissected for whole-exome sequencing (WES). Shared and private alterations as well as genomic alternation characteristics between the two components were investigated. Four public cohorts containing LEP and MIP samples were further selected for genomic profile comparison, novel therapeutic target investigation and immune infiltration quantification.Results: LEP and MIP subtypes exhibited largest disease free survival (DFS) in our patients. A total of 2035 SNV and 2757 InDels were identified in the sequenced LEP and MIP components. EGFR was found with highest mutation frequency. Distinct biological processes or pathways were involved in the evolutionary of the two components. Besides, analyses on copy number variation (CNV) and intratumor heterogeneity further discovered the possible immunosurveillance escape, the discrepancy between mutation and CNV level ITH and the pervasive DNA Damage Response as well as WNT pathway gene alternations in MIP component. Phylogenetic analysis on 5 pairs of LEP and MIP components further confirmed the presence of ancestral EGFR mutations. Through comprehensive analysis in our samples and public cohorts, PTP4A3, NAPRT and RECQL4 were identified as novel therapeutic and diagnostic targets in MIP subtype. Immunosuppression prevalence in MIP component was finally confirmed by multi-omics data.Conclusion: We identified genetic differences responsible for variated prognosis. The subtype evolution trajectory was additionally unraveled. Novel gene targets and the immunological analyses also provided therapeutic suggestions for MIP subtype.
A Rapid Search Method for Scheduling Delivery of Multiple Automated Guided Vehicles
Authors: Meno Koki , Yorozu Ayanori , Ohya Akihisa 
Published: January 2022

Abstract
In this study, a method was developed to address the automated guided vehicle (AGV) transportation scheduling problem. For deliveries in factories and warehouses, it is necessary to quickly plan a feasible transportation schedule without delay within a specified time. This study focused on obtaining a transport schedule without delay from the specified time while maintaining the search for a better solution during the execution of the transport task. Accordingly, a method was developed for constructing a solution with a two-dimensional array of delivery tasks for each AGV, arranged in the order in which they are executed, as well as for searching for a schedule by performing exchange and insertion operations. For the exchange and insertion, a method that considers the connectivity between the end point of a task and the start point of the next task was adopted. To verify the effectiveness of the proposed method, numerical simulations were performed assuming an actual transportation task.
Age-Related Memory and Novel Object Avoidance Differences in Family Dogs: Measuring the Validity and Reliability of a Rapid Behaviour Test Battery
Authors: Piotti Patrizia , Piseddu Andrea , Aguzzoli Enrica , Sommese Andrea , Kubinyi Eniko 
Published: January 2022

Abstract
The prolonged lifespan of companion dogs has resulted in an increased occurrence of behavioural and physical challenges linked to old age. The development of behavioural tests for identifying and monitoring age-related differences has begun. However, standardised testing requires validation. The present study aimed to assess external validity, interobserver reliability, and test-retest reliability of an indoor test battery for the rapid assessment of age-related behavioural differences in dogs. Two experimenters tested young and old dogs on a first occasion and after two weeks. Our results found external validity for two subtests out of six. On both test occasions, old dogs committed more errors than young dogs in a memory test and showed more object avoidance when encountering a novel object. Interobserver reliability and test-retest reliability was high. We conclude that the Memory and Novel object tests are valid and reliable for monitoring age-related memory performance and object neophobic differences in dogs.