bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of oral gabapentin as pre-emptive analgesia in total abdominal hysterectomy- A randomised prospective placebo controlled study
Authors: Sujay J. N  , Prakash B.C  , Kalaburgi Riyaj Ahmad 
Published: November 2022

The postoperative period is an integral part of the surgical experience of the patient. Post-operative pain affects recovery from anaesthesia and surgery. Pre-emptive use of gabapentin speeds up recovery by decreasing post-operative pain.The objectives of the study were to evaluate the effect of oral gabapentin on post-operative pain scores, the request time for first analgesia and the total fentanyl requirement in 12 hours in patient undergoing total abdominal hysterectomy under epidural anaesthesia.: Eighty four patient of ASA grade I and II aged 40 to 60 years, scheduled for total abdominal hysterectomy under epidural anaesthesia were included in the study. Each patient was assigned into two groups (Gabapentin group, group G or Placebo group, group P) of 42 each. Participants in the study were administered 2 capsules (either gabapentin or placebo) one hour before surgery with sips of water. 15ml of Ropivacaine 0.75% was administered into epidural space through 20 gauge epidural catheter. Pain was evaluated post-operatively using visual analogue scale (VAS). Inj. Fentanyl 30 mcg was administered through epidural catheter as rescue analgesia when patients complained of pain.: It was observed that Pain scores were notably lesser in group G as compared to group P at all time points (P&#60;0.05). The first analgesic request time in the control group was significantly less compared to the study group (P&#60;0.001). The amount of fentanyl required in the control group was more compared to study group (P&#60;0.001).: We conclude that the pre-emptive administration of oral gabapentin 600mg significantly reduces pain scores, prolongs the time at which patient requires rescue analgesia and the amount of fentanyl needed was significantly reduced.
Perioperative ventilator-induced lung injury- An unexpected complication of post COVID-19 sequelae
Authors: Jaswal Sofia , Sharma Jagdeep , Mitra Lalita Gouri , Goyal Atin , Walia Harsimran Singh 
Published: November 2022

In today’s era of the COVID-19 pandemic, post-covid lung sequelae increases the incidence of ventilator-induced lung injury in patients undergoing cancer surgeries. A 68 years old female patient underwent surgery for squamous cell carcinoma lower lip under general anesthesia. 10 minutes after reversal and adequate respiratory efforts, sudden desaturation with high peak airway pressures of 35-40 cmH2O was noticed. Bilateral air entry was markedly reduced with crepitus all over the chest and abdomen with stable hemodynamics. Chest X-ray revealed a bilateral deep sulcus sign suggesting bilateral pneumothorax and subcutaneous emphysema. Bilateral thoracostomy tubes were inserted immediately. The saturation and airway pressure improved, and she was extubated the next day. Retrospectively, a possible history of previous undiagnosed COVID-19 infection was sought and this emphasizes the importance of this history, in the ongoing pandemic. Previous history of COVID-19 predisposes patients to a high risk of ventilator-induced lung injury perioperatively.
Anaesthethetic management of craniotomy for recurrent astrocytoma in case of large atrial septal defect with severe pulmonary hypertension: A case report
Authors: Koli Deepak Chandrakant , Gupta Poonam , Katkade Sandip , Gupta Ankit , Mehta Hemant H 
Published: November 2022

In adult population after bicuspid aortic valve, atrial septal defect (ASD) is the most common congenital acyanotic heart disease, with high prevalence in females. Large ASD with pulmonary hypertension (PAH) posted for non-cardiac surgery poses a challenge to anaesthesiologists because intraoperative hypercarbia, hypoxemia, and hyperthermia can result in increased pulmonary vascular resistance (PVR), which can result in shunt reversal, congestive heart failure, and fatal arrhythmias. We report successful anaesthetic management of 48yrs female case of recurrent astrocytoma posted for craniotomy. Patient was having large ostium secundum ASD (35 mm in diameter), with severe PAH having PASP 75mmhg by TR jet, with dilated RA/RV, moderate TR and LVEF 55% under GA, with titrated induction, avoiding rise in PVR and maintaining systemic vascular resistance (SVR) with vasopressors intraoperatively to avoid shunt reversal.:To concludepatients with severe PHT due to large ASD, require meticulous intraoperative management to prevent any rise in PAH, and maintenance of systemic vascular resistance with optimal oxygen delivery and excellent postoperative analgesia for excellent outcome.
Działalność Prezydium Gromadzkiej Rady Narodowej w Górnej Woli (1954–1957)
Authors: Stulczewski Jarosław 
Published: November 2022

Gromadzka Rada Narodowa w Górnej Woli została utworzona w wyniku reformy administracyjnej w 1954 r. W jej skład weszły obszary wsi: Górna Wola, Wilamów, Tarnówka i Rzepiszew z gminy Szadek. Gromadzka Rada Narodowa swoje uchwały realizowała za pośrednictwem prezydium, które było kolegialnym organem wykonawczym i zarządzającym rady narodowej. Zakres kompetencji władz gromady obejmował m.in. uchwalanie rocznego budżetu gromady, zatwierdzanie i odwoływanie sołtysów, organizację skupu żywca, zboża, ziemniaków, mleka oraz zbieranie podatków, sprawy związane z organizacją prac polowych, budową dróg i szkolnictwem. Przewodniczącym Prezydium GRN w Górnej Woli przez cały okres jej istnienia był Teofil Kwiatyszek. Gromada została zlikwidowana 31 grudnia 1957 r.
Nurses Drawdown: Building a Nurse-Led, Solutions-Based Quality Improvement Project to Address Climate Change
Authors: Huffling Katie 
Published: November 2022

Background Climate change is one of the most significant threats to public health we currently face. While the link between climate change and health is clear, many nurses have not received education on climate change, as it may not routinely be included in nursing curricula. This lack of knowledge can prevent nurses from engaging in climate solutions, incorporating climate change into their practice or research, or participating in climate advocacy within their institutions or with policymakers. Methods Nurses Drawdown is a web-based platform that builds on the work of Project Drawdown, which identifies and quantifies effective, evidence-based climate solutions. Nurses Drawdown utilizes evidence-based techniques for web design and movement building to engage a global nursing audience on five areas of action that have clear links to health: Energy, Food, Gender Equity, Mobility, and Nature-Based Solutions. Results: Sixteen nursing organizations signed on with Nurses Drawdown as official partners; within 1 month of going live, nurses from 16 countries had committed to take action. Web-based movement building can effectively engage a global nursing audience. However, new partnerships with nursing organizations may not form until there is proof of nursing engagement.
Exploring the response to a new range of ethanol reductions in Chardonnay and Syrah wines using a Consumer Rejection Threshold approach
Authors: Geffroy Olivier , Pasquier Grégory , Pagès Marielle , Violleau Frédéric 
Published: November 2022

Ethanol is one of the major components of wine, which has a substantial impact on its sensory characteristics. However, data concerning consumer response to ethanol or changes in ethanol remains limited. The aim of this study was to determine the threshold ethanol concentrations beyond which ethanol lowering becomes undesirable in Chardonnay and Syrah wines using the consumer rejection threshold (CRT) methodology. Base wines from these two cultivars were first dearomatised and fully dealcoholised using spinning cone column technology. Then, control wines with a similar ethanol content to the base wines (13.8 and 13.5 % v/v for Chardonnay and Syrah respectively) and wines with lower ethanol contents were reconstituted by mixing the final beverage, the aroma fraction, food grade ethanol and distilled water. CRT values were determined as 2.8 % v/v for Chardonnay and at 7.0 % v/v for Syrah. These particularly low and unexpected concentrations indicate that consumer sensory liking might not be necessarily driven by ethanol concentration, especially for white wines. However, the post-evaluation questionnaire showed that consumers were expecting a high minimal ethanol content for quality wines (10.9 % v/v ± 1.2 and 11.7 % v/v ± 1.5 for white and red wines respectively) and had a limited experience with low and dealcoholised wines. Overall, our data, which are still preliminary and deserve to be validated using different base wines with a larger number of consumers, show that consumers would not necessarily be refractory from a sensory standpoint to the consumption of low ethanol beverages made from wine. Our findings strongly encourage professionals from the wine industry and public authorities to raise awareness about the increase in quality of such products and their benefits for human health.
Pemetaan Peminatan Penelitian Tugas Akhir Mahasiswa Prodi Pendidikan Informatika Fakultas Ilmu Pendidikan Universitas Trunojoyo Madura
Authors: Stefany Evy Maya , Rahayu Ningsih Puji , Arif Muchamad , Mauli Diana Luluk 
Published: November 2022

Tujuan penelitian ini adalah untuk mengetahui peminatan mahasiswa angkatan 2019 Program Studi Pendidikan Informatika dalam memilih bidang penelitian tugas akhir, jenis penelitian serta mengetahui faktor yang menyebabkan mahasiswa lebih memilih penelitian tersebut. Hasil dari penelitian peminatan bidang dan jenis penelitian tugas akhir bisa menjadi acuan untuk pemerataan peminatan penelitian pada Program Studi Pendidikan Informatika. Penelitian ini menggunakan metode deskriptif kualitatif yang dilakukan di Prodi Pendidikan Informatika. Populasi yang digunakan adalah 101 mahasiswa yang sedang mengambil mata kuliah seminar proposal pada semester ganjil 2022/2023. Teknik pengumpulan data menggunakan angket (googleform) dan wawancara. Penelitian ini menggunakan snowball sampling untuk informan dan sebagian yang lain menggunakan purposive..sampling sebagai teknik sampling. Validitas data menggunakan trianggulasi sumber dan reviu informan menggunakan..model analisis flow..model of analysis. Hasil penelitian menunjukkan peminatan penelitian tugas akhir mahasiswa dengan skor tertinggi pada bidang Informatika Terapan (52,4%) pada bidang Pendidikan/pengajaran menunjukkan skor 47,6% untuk jenis penelitian mahasiswa cenderung memilih jenis penelitian kuantitatif (14,8%) penelitian kualitatif (5%) penelitian pengembangan (80,2%). Faktor-faktor peminatan penelitian tugas akhir mahasiswa dipengaruhi oleh beberapa faktor: (1) masalah yang ditemui saat mahasiswa asistensi mengajar; (2) berdasarkan minat/menerapkan ilmu yang diperoleh selama perkuliahan; dan (3) melalui observasi disekolah/instansi.
The characterization of chitinolytic soil bacterial isolates for their antagonistic activity against root-knot nematode Meloidogyne incognita: An effort towards developing 'green' nematicidal agents.
Authors: Pawar Prasad , Doshi Jayraj A , Dandekar Prajakta , Poornima K 
Published: November 2022

Abstract
Root-knot nematodes (Meloidogyne spp.) are one of the most infective pests for a wide range of cultivated plants. The study was aimed to isolate chitinolytic soil bacteria, characterizing their properties, and to determine their in vitro antagonism against root-knot nematode eggs and juveniles. Out of the Ninety-five isolated strains, twenty-five gram-positive and non-hemolytic strains were selected and screened for production of extra-cellular enzymes, such as chitinase, protease, lipase, gelatinase, etc., as well as for biofilm formation, anti-fungal activity, and in vitro antagonism against root-knot nematodes. Eleven strains demonstrated broad anti-fungal activity against common plant pathogenic fungi, like Fusarium oxysporum and Alternaria alternata. Among the twenty-five strains, ten strains exhibited statistically significant (P˂0.05) second stage juvenile (J2s) percent mortality (>60 %) and inhibited egg hatching. The in-vitro activity of these ten strains was found to be correlated with their biofilm formation, enzyme production, and anti-fungal activity. Further, out of these ten strains, nine strains were assigned to the Bacilli group (99-100% similarity), and one was identified as Paenibacillus xylanilyticus (96 % similarity) after sequencing the gyrB gene. Overall, the present in vitro study suggested that the chitinolytic bacterial strains showing biofilm formation, enzyme production, and anti-fungal activity demonstrate an important trait to exhibit antagonism against root-knot nematodes.
An eight ferroptosis-related lncRNA signature predicts the survival of patients with colon adenocarcinoma
Authors: Jing Miaoyu , Zhang Wenjia , Tian Wenying , Xia Min 
Published: November 2022

Abstract
Purpose
This study aimed to discover novel prognostic biomarkers for colon adenocarcinoma (COAD) based on ferroptosis-related lncRNA analysis.
Methods
The RNA-seq data and clinical samples were obtained from TCGA database. Ferroptosis-related genes used were downloaded from the GSEA database. We screened ferroptosis-related lncRNAs with correlation coefficient \(\left|R\right|\)>0.3 and P < 0.001. By Cox analysis and LASSO regression, the prognostic ferroptosis-related lncRNAs were identified and their risk scores were obtained. Combining risk scores and clinical features, a nomogram was constructed and was validated by C-index, AUC and calibration diagram.
Results
An eight-lncRNAs signature was built up, comprising ZEB1-AS1, AL354993.2, LINC02381, AP001505.1, NCK1-DT, CD27-AS1, AC068580.3 and SNHG16. The AUC of ROC curve was 0.737 in predicting 3-years survival and 0.785 in predicting 5-years survival and C-index was 0.795 in the prognostic model.
Conclusions
ZEB1-AS1, AL354993.2, LINC02381, AP001505.1, NCK1-DT, CD27-AS1 and AC068580.3 may be negative factors while SNHG16 may be a positive factor for the survival time of COAD patients. The eight ferroptosis-related lncRNA signature has a certain capability in predicting the overall survival of patients with COAD and these selected lncRNAs may serve as novel prognostic biomarkers.
Evaluating the nutritional values and safety levels of oven-dried whole (full-fat) mealworms and de-oiled mealworms under different storage intervals
Authors: Khan Sarzamin , Usman Amjad , kHAN Kamran , Ali Pervez , Shah Ezaz Ali , Khan Haris , Abbas Mohammad Israr 
Published: November 2022

Abstract
Mealworms (Tenebrio molitor) are considered the potential novel alternative source of protein for sustainable food production and also have a low ecological footprint. Nonetheless, fresh mealworms have a shorter shelf-life, therefore, to preserve their nutrient quality and safety it is of utmost importance to optimize the post-harvest processing techniques. Therefore, in the present study two technological forms of oven-dried (60 0Ċ for 2 h) mealworms namely whole (full-fat) mealworms (WMW) and de-oiled mealworms (D-OMW) were analysed for nutrient quality, microbial count, and aflatoxin B1 safety levels. Both WMW and D-OMW were stored for 56 days at room temperature (25 to 30 0C) and were sampled on alternate weeks (days 0, 14, 28, 42, and 56, respectively) for analysis. In comparison to WMW, the D-OMW contains high (P < 0.001) contents of crude protein (CP) and dry matter (DM). Notably, at 56 days of storage interval, the D-OMW is more stable with CP and DM contents having DM (87.3 vs. 77.3%) and CP (76 vs. 46.0%) contents. In contrast, WMW had high (P < 0.001) content of EE than D-OMW (24.5 vs. 3.30%) at 56 days of storage. Moreover, WMW and D-OMW are rich sources of minerals, particularly potassium and phosphorus, with no significant (P > 0.05) effect during storage interval. Notably, leucine, lysine, and valine are the abundant amino acids in WMW and D-OMW. During the entire storage period, no growth of Escherichia coli, Salmonella, Campylobacters, and Clostridium perfringens were found. However, low levels of other coliforms, Enterococci, and Staphylococcus aureus were detected in D-OMW than in WMW. Likewise, the aflatoxin B1 contamination level was much lower in D-OMW during the entire storage time. This study concluded that storage times affected the nutrient profile and safety level of WMW. Nonetheless, the D-OMW was found almost stable and safe even at the storage of 56 days at room temperature.
Construction and verification of prediction models for intrapartum cesarean section to be used at full-term pregnant women with singleton and cephalic presentation under the new labor standard: a retrospective case-control study
Authors: Liu Yuanying , Ye Shenglong , Ma Yue , Zhao Xueqing , YONGQING WANG 
Published: November 2022

Abstract
Purpose:

This study aimed to explore the risk factors associated with intrapartum cesarean section and construct prediction models for intrapartum cesarean section under the new labor standard.

Methods:

This was a retrospective case-control study at Peking University Third Hospital in China from June 2020 to October 2021. Full-term pregnant women were allowed to have a trial of labor, including singleton and cephalic presentation. Herein, a total of 20 parameters relevant to maternal and obstetric characteristics were listed as candidate predictors. In addition, univariate and multivariate logistic regression analyses were used to construct the prediction model. Two prediction models were included: Model A is for the gravida before the trial of labor and model B is for those already at the active phase. Then, the calibration, discrimination, and clinical utility of the models was assessed and an internal validation was performed. Finally, the models were ultimately transformed into nomograms for clinical use.

Results:

The predictors in model A were older maternal age, shorter in height, longer gestational age, heavier in weight, primipara, lower Bishop score, complicated hypertensive disorder, receiving labor induction and heavier estimation of fetal weight(EFW) within one week before delivery. In model B, height, weight gain during pregnancy, complicated hypertensive disorder, receiving labor induction, analgesia, assist reproductive technology, latent period duration,delivery at night and EFW were included. The models showed satisfactory discrimination, calibration, and high clinical net benefit.

Conclusion:

The prediction models for an intrapartum cesarean section can accurately predict the risk of cesarean section; This prediction model can provide guidance for clinicians in the management of labor, grasp the appropriate indications for cesarean section, avoid excessive trial labor, and reduce maternal and infant complications.
RTNet: A neural network that exhibits the signatures of human perceptual decision making
Authors: Rafiei Farshad , Rahnev Dobromir 
Published: November 2022

Abstract
Convolutional neural networks currently provide the best models of biological vision. However, their decision behavior, including the facts that they are deterministic and use equal number of computations for easy and difficult stimuli, differs markedly from human decision-making, thus limiting their applicability as models of human perceptual behavior. Here we develop a new neural network, RTNet, that generates stochastic decisions and human-like response time (RT) distributions, and also reproduces all foundational features of human accuracy, RT, and confidence. To test RTNet’s ability to predict human behavior on novel images, we collected accuracy, RT, and confidence data from 60 human subjects performing a digit discrimination task. We found that the accuracy, RT, and confidence produced by RTNet for individual novel images correlated with the same quantities produced by human subjects. Critically, human subjects who were more similar to the average human performance were also found to be closer to RTNet’s predictions. Overall, RTNet is the first neural network that exhibits all basic signatures of perceptual decision making.
ADORA2A promotes proliferation and inhibits apoptosis through PI3K/AKT pathway activation in colorectal carcinoma
Authors: Ran Longyan , Mou Xiao , Peng Zhenglin , Li Xiaochen , Li Meirong , Xu Duo , Yang Zixi , Sun Xingwang , Yin Tao 
Published: November 2022

Abstract
Background：The third most often diagnosed disease globally and the second most prevalent cause of cancer-related death is colorectal cancer (CRC). Numerous human malignancies have been identified to overexpress ADORA2A. However, it is still ambiguous about its function in CRC.
Methods: RNA-seq with stable transfected SETDB1 knockdown cells was used to identify the differentially expressed genes. Further, knockdown of ADORA2A in CRC cell lines SW620 and HCT116 were performed with siRNA and overexpression of ADORA2A in SW480 cells were conducted with plasmid. CCK8, colony formation, wound healing and transwell assay were used to detect the effects of cell proliferation, migration and invasion after knockdown and overexpression of ADORA2A. Also, apoptosis was analyzed by flow cytometry, apoptosis-related proteins and key PI3K/AKT pathway proteins were detected using western blotting.
Results: ADORA2A was obtained with RNA-seq and played an important role in CRC prognosis. ADORA2A was relatively high expressed in SW620 and HCT116 cell lines compared to SW480 cell line. Knockdown of ADORA2A in SW620 and HCT116 cell lines inhibited cell proliferation, migration and invasion while overexpression of ADORA2A had the opposite results. In addition, ADORA2A also impacted the expression of apoptosis-related proteins, including as Bcl-2, Bax, caspase3 and caspase9, and reduced apoptosis. Furthermore, this process may include the PI3K/AKT signal pathway.
Conclusion: ADORA2A promotes CRC progression by PI3K/AKT signaling pathway. It might contribute to management and treatment of CRC.