bluuebunny/crossref_metadata_2025_split huggingface dataset:
CYLD and HER3 Regulate Platinum Resistance in Ovarian Cancer via Drug Efflux Pump ABCB1
Authors: Zhang Ye , Jia Xiao-Yu , Wang Wei , Qiu Jian-Ge , Liu Wen-Jing , Ding Chen , Wang Lin , Jiang Bing-Hua 
Published: February 2022

Abstract
Background: Ovarian cancer (OC) is the most pathogenic gynecological malignant tumor in the world. Due to the difficulty of early diagnosis, most of patients developed chemo-resistance and recurrence during and after the chemotherapy. Methods: CCK8 and flow cytometry analysis were used to analyze the drug sensitivity and apoptosis effect in drug resistant and their parental cell lines (A2780, A2780-DDP, OVCAR3, OVCAR3-DDP). Cells with CYLD knockdown or overexpression were used to test its role in DDP resistance. Patient tumor samples were used to study the clinical significance of CYLD and its related molecules. Flow cytometry analysis were used to test the drug efflux effects in CYLD knockdown cells. The drug combination method were used to investigate the drug synergistic effect of cisplatin combination with ABCB1 inhibitor or HER3 inhibitor. The protein and RNA levels were determined by Western blot analysis, PCR and immunoprecipitation. The in vivo experiments were used to verify the role of CYLD in drug resistance of ovarian cancer and tumor growth.Results: we found levels of CYLD were markedly lower in ovarian DDP-resistant cancer cell lines than those of parental cell lines. CYLD knockdown in the parental cells alone was sufficient to induce DDP resistance through inhibiting cell apoptosis and promoting the drug efflux via inducing the expression of ABCB1. HER3 expression levels were much higher in the resistant cells, and HER3 was upstream mediator of CYLD suppression in the cells through STAT3 signaling. Moreover, overexpression of CYLD in the resistant cells alone was sufficient to reverse the resistant cells to become sensible to platinum-based treatment both in vitro and in vivo. Similar result showed that ABCB1 was functional downstream target of CYLD to regulate tumor growth and drug resistance both in vitro and in vivo.Conclusions: In this study, the results demonstrated that CYLD suppression and higher HER3 expression caused cisplatin resistance and poor prognosis by inhibiting cell apoptosis and promoting the drug efflux in OC. Our findings showed that HER3/CYLD/ABCB1 is a new signaling pathway to regulate tumor growth and DDP resistance, which is potential new therapeutic target to overcome DDP resistance.
Association between the IL-7Rα gene polymorphisms of rs6897932 and rs987106 with atopic diseases: A case-control design
Authors: Baghbadorani Parnian Zolfaghari , Damavandi Amirmasoud Rayati , Kardedeh Bahareh , Mostafavi Samaneh , Salehi Rasoul , Kazemi Mohammad , Ghasemi Ramin , Eskandari Nahid , Fathi Farshid 
Published: February 2022

Abstract
Background
Atopy is used to describe the genetic tendency to IgE-mediated responses. Many factors contribute to predisposing individuals to atopy, including cytokines. IL-7 is a cytokine that mediates hypersensitivity responses and proliferation of T cells and has a polymorphic gene for its receptor (CD127). These different alleles may affect the signaling cascade or alter the production of inflammatory cytokines, which may exacerbate atopic conditions, including asthma and allergy.
Objective
Primary objective of our study aimed to explore the linkage between IL-7Rα gene polymorphism at the SNP of rs6897932 and the risk of atopic diseases. Evaluating the association of IL-7Rα SNP of rs987106 and also serum levels of IL-7 with the risk of atopy are among the secondary objectives.
Methods
To seek possible relations of SNPs rs6897932 and rs987106 with the risk of atopy, we recruited 101 atopic patients and 201 sex-age matched healthy controls from Iranian ethnicity and used the data for evaluation.
Results
Statistical analysis revealed that the T allele variant of IL-7Rα gene at the SNP of rs6897932 is more prevalent among the atopic patients (53.5%) than in the controls (26.9%) and have a considerable association with the disease (p < 0.0001, OR: 3.13 (95% CI- 1.90 to 5.16)). Also, the higher frequency of T allele variant of rs987106 in atopic patients (64.4%) versus control (31.3%) was associated with around a 4-fold increase in the risk of atopy (p < 0.0001, OR: 3.95 (95% CI- 2.39 to 6.55)). However, there was no significant association between IL-7 serum levels and atopic disorders (p > 0.05).
Conclusion
Our study in the Iranian population may support that T allele variants of rs6897932 and rs987106 are risk factors for atopy. However, serum levels of IL-7 were not significantly associated with a heightened risk of atopy.
Characteristics of the clinicopathology and immune microenvironment of the basal-like phenotype in HR+/HER2-breast cancer
Authors: Jiehua He , Zhang Jinhui , Pan Lu , Zhou Zhishan , Chen Keming , Lu Jiabin , Li Mei , Chao Xue , Luo Rongzhen , Sun Peng 
Published: February 2022

Abstract
Background Expression of basal-like markers (BMs) is usually observed in triple-negative breast cancer (TNBC) and HER2-overexpressing breast cancer and is related to poor prognosis. Recently, some have reported that BM is expressed in 7.8%-27.1% of HR+/HER2- breast cancers (basal-like phenotype, BM+ BCs), but their biological behaviours remain controversial. This study aimed to compare the differences in clinicopathologic features, clinical outcomes and benefit from adjuvant regimens between BM+ BCs and nonbasal-like phenotype breast cancer (BM- BCs) and evaluate their tumour immune microenvironment.Methods BM+ BCs were defined as EGFR- and/or CK5/6-positive (n=150). Overall, 180 BM- BCs were selected as the control cohort. Clinicopathological characteristics were retrospectively collected. Univariate and multivariate analyses were used to assess the relationship between disease-free survival (DFS), overall survival (OS) and BM status. Stromal tumour-infiltrating lymphocytes (sTILs) were evaluated on haematoxylin & eosin-stained slides, and CD3, CD8, FOPX3, chemokine (C-X-C motif) ligand 13 (CXCL13), CD68, PD-1 and PD-L1 were stained by IHC.Results Compared to BM- BCs, BM+ BCs were more frequently diagnosed at a younger age and had a higher tumour stage, histological grade and necrosis. No obvious differences were seen in lymphovascular invasion or lymph node metastasis. Lower ER and PR expression and higher Ki-67 expression were observed in BM+ BCs. Overall, 62.8% BM+ BCs had p53 mutations. Shorter DFS and OS were related to BM+ BCs (p=0.021 and 0.018, respectively). In multivariate analysis, CK5/6 and clinical stage were independent prognostic factors for DFS and OS. BM+ BCs had a higher proportion of high sTILs with increased CD3, CD8, FOXP3, CXCL13 and CD68 expression. PD-1 and PD-L1 expression was positively related to BM+ BCs.Conclusion Our study demonstrated that more aggressive morphologic features and worse prognosis were associated with BM+ BCs, and its immune-activated status may support new therapeutic strategies, such as immunotherapy, as a potential treatment.
On the incompressible behavior in weakly nonlinear elasticity
Authors: Kube Christopher 
Published: February 2022

Abstract
This article considers the influence of incompressibility on the compliance and stiffness constants that appear in the weakly nonlinear theory of elasticity. The formulation first considers the incompressibility constraint applied to compliances, which gives explicit finite limits for the second-, third-, and fourth-order compliance constants. The stiffness/compliance relationships for each order are derived and used to determine the incompressible behavior of the second-, third-, and fourth-order stiffness constants. Unlike the compressible case, the fourth-order compliances are not found to be dependent on the fourth-order stiffnesses.
Split Monotone Variational Inclusion With Errors for Image Feature Extraction With Multiple-image Blends Problem
Authors: TIANCHAI PATTANAPONG 
Published: February 2022

Abstract
In this paper, we introduce a new iterative forward-backward splitting algorithm with errors for solving the split monotone variational inclusion problem of the sum of two monotone operators in real Hilbert spaces. We suggest and analyze this method under some mild appropriate conditions imposed on the parameters such that another strong convergence theorem for this problem is obtained. We also apply our main result to image feature extraction with multiple-image blends problem and the split minimization problem, and provide numerical experiments to illustrate the convergence behavior and show the effectiveness of the sequence constructed by the inertial technique.
A Comparative Evaluation of Anti-Inflammatory and Arthritic Effects of bradykinin inhibitor Zaltoprofen over Piroxicam in Murine models: A randomized experimental study.
Authors: Sadasivam. Balakrishnan , Chenchula SANTENNA , kumar Sunil , Jhaj Ratinder , Pathan Saman 
Published: February 2022

Abstract
Background and Aims: Inflammation is an essential biochemical protective response of vascularized tissues, broadly classified into acute and chronic inflammation. Zaltoprofen, a unique propionic acid group of NSAID, acts by blocking the augmenting effect of bradykinin. The present study was conducted to evaluate the acute and chronic anti-inflammatory (arthritic) potential of Zaltoprofen over piroxicam in murine models. Methods:A total of 24 healthy Wister rats (200–250 g) of either sex (24 in each model) were obtained from the central animal house, AIIMS, Bhopal and categorized into four different groups, six in each. Zaltoprofen was used as a test and Piroxicam as a Standard (Per Os) agent. The anti-inflammatory or arthritic potential was evaluated and compared by acute and chronic inflammation (carrageenan and formalin-induced)models. Results:In the acute inflammation model, Zaltoprofen when compared to Negative control (NaCl 10ml/kg) there was a significant inhibition in paw volume (P< 0.001) at different time scales with two different doses of Test compound (Zaltoprofen 10&20mg/kg). However, in the chronic inflammation model, Zaltoprofen 10 mg/kg & 20mg/kg doses of the Test compound had been shown a significant reduction in the chronic inflammation comparable to the negative control (NaCl 10ml/kg), though the efficacy was lesser than Positive control (Piroxicam 10mg/kg) (P≤ 0.05). Conclusions:Zaltoprofen possesses significant acute and chronic anti-inflammatory and arthritic effects by inhibiting various inflammatory mediators. Therefore, Zaltoprofen can be explored as a potential alternative agent for the treatment of acute inflammatory and chronic inflammatory or arthritis conditions in human beings.
A comprehensive SARS-CoV-2-human protein-protein interactome network reveals novel pathobiology and host-targeting therapies for COVID-19
Authors: Zhou Yadi , Liu Yuan , Gupta Shagun , Paramo Mauricio I. , Hou Yuan , Mao Chengsheng , Luo Yuan , Judd Julius , Wierbowski Shayne , Bertolotti Marta , Nerkar Mriganka , Jehi Lara , Drayman Nir , Nicolaescu Vlad , Gula Haley , Tay Savaş , Randall Glenn , Lis John T. , Feschotte Cédric , Erzurum Serpil C. , Cheng Feixiong , Yu Haiyuan 
Published: February 2022

Abstract
Physical interactions between viral and host proteins are responsible for almost all aspects of the viral life cycle and the host’s immune response. Studying viral-host protein-protein interactions is thus crucial for identifying strategies for treatment and prevention of viral infection. Here, we use high-throughput yeast two-hybrid and affinity purification followed by mass spectrometry to generate a comprehensive SARS-CoV-2-human protein-protein interactome network consisting of both binary and co-complex interactions. We report a total of 739 high-confidence interactions, showing the highest overlap of interaction partners among published datasets as well as the highest enrichment for genes differentially expressed in samples (such as upper airway and bronchial epithelial cells) from patients with SARS-CoV-2 infection. Showcasing the utility of our network, we describe a novel interaction between the viral accessory protein ORF3a and the host zinc finger transcription factor ZNF579 to illustrate one of the first examples of a viral factor mediating a direct impact on host transcription. Leveraging our interactome, we performed network-based drug screens for over 2,900 FDA-approved/investigational drugs and obtained a curated list of 21 drugs that had significant network proximities to SARS-CoV-2 host factors, one of which, carvedilol, showed promising antiviral properties. We performed electronic health record-based validation using two independent large-scale, longitudinal COVID-19 patient databases and found that carvedilol usage was associated with a significantly lowered probability (17%-20%, P < 0.001) of obtaining a SARS-CoV-2 positive test after adjusting various confounding factors. Carvedilol additionally showed anti-viral activity against SARS-CoV-2 in a human lung epithelial cell line (EC50 value of 4.1 µM), suggesting a mechanism for its beneficial effect in COVID-19. Our study demonstrates the value of large-scale network systems biology approaches for extracting biological insight from complex biological processes.
A study on Morphological and Mechanical Characterization of Al-4032/SiC/GP Hybrid Composites
Authors: Kumar Deepak , Saini Pardeep , Singh Pradeep K. 
Published: February 2022

Abstract
The pattern of metal matrix composites can be enhanced by integrating the concept of hybrid metal matrix composite to produce newer engineering materials with improved properties. The morphological and mechanical characteristics of Al-4032/SiC/GP hybrid composites have been investigated. The aluminium alloy (Al-4032) based hybrid composites have been fabricated through the bottom pouring stir casting set up, by reinforcing the silicon carbide (SiC) and granite powder ceramic particles as the reinforcement material at various fraction level i.e. 0, 3, 6, 9 weight% in equal proportion. The reinforcement particle size is up to 54μm. The microstructural characterization of the hybrid composite samples has been carried out using optical microscope, SEM and XRD. The study reveals that the reinforcement hybrid particles (SiC + GP) are almost uniformly distributed throughout the matrix phase. The mechanical properties (tensile strength, impact strength and microhardness) of the hybrid composite samples have been obtained and found to be better than the unreinforced alloy.
Expect the Unexpected: A Qualitative Study of the Ripple Effects of Children’s Mental Health Services Implementation Efforts
Authors: Pullmann Michael D. , Dorsey Shannon , Duong Mylien T. , Lyon Aaron R. , Muse Ian , Corbin Cathy M. , Davis Chayna J. , Thorp Kristin , Sweeney Millie , Lewis Cara C. , Powell Byron J. 
Published: February 2022

Abstract
Background: Strategies to implement evidence-based interventions (EBIs) in children’s mental health services have complex direct and indirect causal impacts on multiple outcomes. Ripple effects are outcomes that are caused by EBI implementation efforts and are unplanned, unanticipated, and/or more salient to stakeholders other than to researchers and implementers. The purpose of the current paper is to provide a compilation of possible ripple effects associated with EBI implementation strategies in children’s mental health services, to be used for treatment development, implementation planning, research, and quality improvement. Methods: Participants were identified via expert nomination and snowball sampling. Online surveys were completed by 81 participants who contributed ripple effects, each representing one of five roles: providers of mental health services to children or youth, researchers, policy makers, caregivers, and youth. A partially directed conventional content analysis with consensus decision making was used to code ripple effects. Results: Four hundred and four unique responses were coded into 66 ripple effects and 14 categories. Example categories include general knowledge, skills, attitudes, and confidence about using EBIs; general job-related ripple effects; EBI treatment adherence, fidelity, and alignment; gaming the system; equity and stigma; shifting roles, role clarity, and task shifting; economic costs and benefits; EBI treatment availability, access, participation, attendance, barriers, and facilitators; clinical process and treatment quality; client engagement, therapeutic alliance, and client satisfaction; clinical organization structure, relationships in the organization, process, and functioning; youth client and caregiver outcomes; and use of EBI strategies and insights in one’s own life. Conclusions: This research advances the field by providing children’s mental health implementers, researchers, funders, policy makers, and consumers with a menu of potential ripple effects for consideration when evaluating implementation quality and impact. It can be a practical tool to ensure compliance with the guidance of experts from Quality Improvement/Quality Assurance, Complexity Science, Diffusion of Innovation Theory, and the Medical Research Council. Future phases will match potential ripple effects with the most salient children’s mental health implementation strategies for each participant role. Trial Registration: None.
Influence of Soot Aerosol on Satellite-ground Quantum Communication Performance
Authors: Zhang Xiuzai , Tan Xin , Zhai Mengsi , Zhou Lijuan 
Published: February 2022

Abstract
Soot aerosol is an important part of atmospheric aerosol, which has important influence on the propagation of quantum signal. In order to study the influence of soot aerosol on satellite-ground quantum communication, according to the size distribution parameter and extinction coefficient of the soot aerosol, the influence of the concentration of the soot aerosol particles and the transmission distance on the attenuation of the link is analyzed. The simulation experiments of channel capacity, channel fidelity and channel bit error rate (Ber) are carried out with amplitude-damped channel. The simulation results show that the soot aerosol concentration increases from 2.1×10 6 / m 3 to 3.2 10× 6 / m 3 , the link attenuation factor increases from 0.3dB/ km to 0.46dB/ km, the fidelity decreases from 0.98 to 0.97, and the bit error rate increases from 0.0087 to 0.0122 at a transmission distance of 3km . hhen the transmission distance is 6km and the particle concentration is 2.1×10 6 / m 3 , 2.7 10× 6 / m 3 and 3.9×10 6 / m 3 , the channel capacity increases from 1.078 to 1.0809, and then decreases to 1.0804. Therefore, the soot aerosol has influence on the performance of satellite-ground quantum communication, and the degree of influence is different. In order to ensure the reliability of quantum communication between satellite and ground, the parameters can be adjusted to ensure the normal transmission of quantum signal.
Extraction And Characterization Of Cellulose Whiskers From The Brazilian Semiarid Northeast: Caroá And Macambira Fibers
Authors: Macedo Murilo J. P. , Santos Amelia S. F. , Oliveira Juliano E. , Medeiros Eliton S. 
Published: February 2022

Abstract
Cellulose nanocrystals were successfully extracted from caroá (Neoglaziovia variegata) and macambira (Bromelia laciniosa) fibers, which are native plants from the semi-arid Caatinga biome in Northeastern Brazil. Fibers were submitted to alkaline and bleaching treatments prior to sulfuric acid extraction. Morphology and chemical composition (holocellulose and cellulose content) of fibers were determined by scanning electron microscopy and chemical analysis, respectively. Cellulose nanocrystal structure, crystallinity and thermal stability were determined respectively by atomic force microscopy and thermogravimetric analysis. Results show that mercerization followed by bleaching were able to remove waxes and amorphous regions. Caroá fibers required one mercerization and three bleaching steps while macambira needed one mercerization and two bleaching steps prior to nanocrystal extraction. Alkaline treated and bleached samples had lower thermal stability as compared to untreated fibers due to removal of lignin and increased surface area. Caroá and macambira are renewable sources of cellulose nanocrystals with potential applications as reinforcements to nanocomposites.
The latest research trends in primary biliary cholangitis: A bibliometric analysis
Authors: Zhao Yu , Yin Zhenjie , Du Huang , Huang Kangming , Zhang Fajing , Chen Hongbin 
Published: February 2022

Abstract
Background and aims: The bibliometric analysis uses the citation count of an article to measure its impact in the scientific community, but no study has been undertaken to determine the most influential papers in the field of primary biliary cholangitis (PBC). This study aimed to investigate the global research interest regarding PBC in dentistry using a bibliometric approach. Methods: We searched the Web of Science Core Collection database to find the top 100 most cited (T100) articles focusing on PBC. The information about each article including citations, authors, journals, countries, institutions, and keywords was recorded for bibliometric analysis. Results: The T100 articles related to PBC were published from 1983 to 2019 and were originated from 26 countries. A total of 805 different authors were from 342 different institutions, and articles written by them were published in 35 journals. The five most frequently occurring keywords were “biochemical response”, “ursodeoxycholic acid”, “primary biliary cirrhosis”, “antimitochondrial antibody”, and “autoimmunity”. The T100 articles were classified into different research focuses: pathogenesis (41%), treatment (20%), prognosis (12%), epidemiology (9%), diagnosis (8%) and others (10%). These 100 articles included 32 observational studies, 29 basic research articles, 15 reviews, eight meta-analyses, 12 clinical trials, and four clinical guidelines. Conclusions: This report presents major advances and changes in research regarding PBC. The single treatment method entered a bottleneck period, and combined treatment with immunosuppressant, local therapy, and surgery will become the next research focus to identify possible beneficial treatment combinations.