bluuebunny/crossref_metadata_2025_split huggingface dataset:
A hybrid concentrated solar/biomass combustion system with internal thermal energy storage for fully dispatchable renewable electricity production in Mauritius
Authors: Boretti Alberto 
Published: April 2022

AbstractWind and solar photovoltaic need expensive battery energy storage for dispatchability. Concentrated solar power plus internal thermal energy storage permits dispatchability, but it is convenient only in areas of large direct normal irradiance. A hybrid concentrated solar/combustion system is proposed for Mauritius, an area of modest direct normal irradiance, and biomass availability. The small, modular, 8 kW system for microgrid application comprises a beam down point concentrator, two tanks of molten salt thermal energy storage, a biomass combustion heater, a Stirling engine, and a generator. The hybrid system has a thermal energy supply solar of 41%, and a thermal energy supply by combustion fuel 59%. By assuming a zero CO2e emission for solar thermal energy supply (100% reduction of CO2e) and a 21% CO2e emission for thermal energy from the combustion of bagasse (79% reduction) vs thermal energy from oil combustion, the proposed hybrid device would permit an 88% reduction of the emission of CO2 vs the reference oil combustion plant.
Saving: Towards a Feminist Reckoning
Authors: Cromer Risa 
Published: April 2022

AbstractLila Abu‐Lughod suggested saving as a keyword twenty years ago by imploring feminist anthropologists to “be wary” saving discourses and actions, especially when they appear in a sympathetic form. Heeding this call in a sustained way remains a crucial task. Being wary of saving in a systematic way investigates what gives it broad‐reaching appeal and power; how and where saving rhetoric is wielded by diverse agents; and why and how particular life‐forms are deemed worthy of protection while many others are not. Being wary of saving supports reflexive considerations of how saving discourses operate within anthropology broadly, and feminist anthropology specifically, toward clarifying what an otherwise world “beyond” or “without” saving could look like.
Connectomic assessment of injury burden and longitudinal structural network alterations in moderate‐to‐severe traumatic brain injury
Authors: Osmanlıoğlu Yusuf , Parker Drew , Alappatt Jacob A. , Gugger James J. , Diaz‐Arrastia Ramon R. , Whyte John , Kim Junghoon J. , Verma Ragini 
Published: April 2022

AbstractTraumatic brain injury (TBI) is a major public health problem. Caused by external mechanical forces, a major characteristic of TBI is the shearing of axons across the white matter, which causes structural connectivity disruptions between brain regions. This diffuse injury leads to cognitive deficits, frequently requiring rehabilitation. Heterogeneity is another characteristic of TBI as severity and cognitive sequelae of the disease have a wide variation across patients, posing a big challenge for treatment. Thus, measures assessing network‐wide structural connectivity disruptions in TBI are necessary to quantify injury burden of individuals, which would help in achieving personalized treatment, patient monitoring, and rehabilitation planning. Despite TBI being a disconnectivity syndrome, connectomic assessment of structural disconnectivity has been relatively limited. In this study, we propose a novel connectomic measure that we call network normality score (NNS) to capture the integrity of structural connectivity in TBI patients by leveraging two major characteristics of the disease: diffuseness of axonal injury and heterogeneity of the disease. Over a longitudinal cohort of moderate‐to‐severe TBI patients, we demonstrate that structural network topology of patients is more heterogeneous and significantly different than that of healthy controls at 3 months postinjury, where dissimilarity further increases up to 12 months. We also show that NNS captures injury burden as quantified by posttraumatic amnesia and that alterations in the structural brain network is not related to cognitive recovery. Finally, we compare NNS to major graph theory measures used in TBI literature and demonstrate the superiority of NNS in characterizing the disease.
A new detection system for serum fragmented cytokeratin 18 as a biomarker reflecting histologic activities of human nonalcoholic steatohepatitis
Authors: Eguchi Akiko , Iwasa Motoh , Yamada Minori , Tamai Yasuyuki , Shigefuku Ryuta , Hasegawa Hiroshi , Hirokawa Yoshifumi , Hayashi Akinobu , Okuno Koji , Matsushita Yuki , Nakatsuka Takuma , Enooku Kenichiro , Sakaguchi Koji , Kobayashi Yoshinao , Yamaguchi Tetsuji , Watanabe Masatoshi , Takei Yoshiyuki , Nakagawa Hayato 
Published: April 2022

Abstract
Caspase‐generated fragmented cytokeratin 18 (fCK18) is recognized as a useful noninvasive biomarker in the diagnosis of nonalcoholic fatty liver disease (NAFLD), particularly nonalcoholic steatohepatitis (NASH). However, fCK18 measurement is not applied clinically due to widely variable cut‐off values under the current enzyme‐linked immunosorbent assay platform. Therefore, we developed a highly sensitive chemiluminescent enzyme immunoassay using newly developed monoclonal antibodies against fCK18 and investigated its relevance in NASH diagnosis. Serum fCK18 levels were measured in the derivation and validation cohort. The correlation between serum fCK18 levels and NAFLD activity score (NAS), fibrosis stage, and liver function was examined. Serum fCK18 levels were significantly correlated with alanine aminotransferase (ALT), aspartate aminotransferase (AST), and gamma‐glutamyl transpeptidase. Serum fCK18 levels were significantly associated with NAS, Brunt's grade/stage, Matteoni's classification, portal inflammation, and fat accumulation in the liver. Notably, hepatocyte ballooning was the only independent variable significantly associated with serum fCK18 in the multivariate linear regression analysis. Serum fCK18 levels were significantly elevated in patients with NAFLD and nonalcoholic fatty liver (NAFL) compared to healthy individuals. They were also significantly elevated in patients with NAFL compared to NASH defined by NAS or Matteoni's classification, with area under the curve values being 0.961 (NAFLD vs. healthy), 0.913 (NAFL vs. healthy), 0.763 (NASH vs. NAFL), and 0.796 (NASH type 3–4 vs. NAFL type 1–2). These results were confirmed by a validation cohort. Notably, changes over time in serum fCK18 levels were significantly correlated with changes in ALT, AST, and the fibrosis‐4 index in 25 patients who underwent lifestyle modification. Serum fCK18 levels were significantly correlated with liver damage associated with NASH pathology. Serum fCK18 levels are accurate in distinguishing patients with NAFL or NASH from healthy individuals and may be useful to monitor NASH over time.
The relationship between team dynamics with healthcare coordination and clinical work satisfaction among Commune Health Workers: A Bayesian model averaging study
Authors: Ngo Tuan Tri , Van Nguyen Huy , Pham Thanh Hai , Van Nguyen Tien , Vu Kien Duy , Pham Minh Duc , Phung Dung , Thi Tran Anh Ngoc , Nguyen Phuong The , Le Phuong Mai , Thi Dao An Minh , Ngo Hiep Tri , Van Hoang Minh 
Published: April 2022

AbstractObjectiveTo determine the relationship between team dynamics with healthcare coordination and clinical job satisfaction of the community health workers (CHWs).MethodsA cross‐sectional study was conducted among 133 health workers (including doctors, nurses, or midwives) at 21 Commune Health Cent in Quoc Oai District, Vietnam, from July 2015 to May 2017. A self‐administered questionnaire consisting of 5‐Likert items regarding team dynamics and healthcare coordination clinical work satisfaction was utilised. Descriptive statistics and correlation matrix were applied for seven factors of team dynamic, clinical work satisfaction, and patient care coordination queried by primary care providers. Bayesian model averaging (BMA) was used to identify the predictors of the level of team dynamics and healthcare coordination.ResultsThe mean score of overall team dynamics among the study participants was 4.08. Clinical work satisfaction and patient care coordination scores among resident physicians were higher than those of attending clinicians; however, the differences were not statistically significant. The results of BMA analysis indicated that team dynamics significantly associated with clinical work satisfaction, and it explains 9% of the total variance in clinical work satisfaction. Team dynamics level was also positively associated with patient care coordination. Patient care coordination was not a significant mediator between team dynamics and clinical work satisfaction.ConclusionTeam dynamics is a potential contributor to improving patient care coordination and clinical job satisfaction of CHWs. As no significant correlation between patient care coordination and clinical job satisfaction was observed, to improve team performance, providing conditions that facilitate team building and teamwork should be conducted for CHWs in CHCs.
Irreversibility analysis of micropolar nanofluid flow using Darcy–Forchheimer rule in an inclined microchannel with multiple slip effects
Authors: Gireesha Bijjanal J. , Anitha Lokeshappa 
Published: April 2022

AbstractThe present work explores the consequence of the flow of micropolar fluid in an inclined microchannel when exposed to linear radiation in presence of a magnetic field. The microchannel is embedded with a porous medium and the Darcy–Forchheimer model is implemented. The walls of the microchannel facilitate the simultaneous suction and injection of the micropolar fluid. A multiple slip regime and temperature jump conditions were assumed at the boundaries. The equations are modeled and nondimensionalized using nondimensional entities and further solved with the aid of the Runge–Kutta–Fehlberg method. Entropy generated in the medium and ratio of irreversibilities is also computed. Results so obtained deliberate that enhancement in Darcy number has caused an increment in entropy generation rate whereas the opposite nature is attained for the Bejan number. Magnifying the radiation parameter has resulted in diminishing the profile of entropy generation rate and Bejan number.
The landscape of genetic aberrations in myxofibrosarcoma
Authors: Takeuchi Yasuhide , Yoshida Kenichi , Halik Adriane , Kunitz Annegret , Suzuki Hiromichi , Kakiuchi Nobuyuki , Shiozawa Yusuke , Yokoyama Akira , Inoue Yoshikage , Hirano Tomonori , Yoshizato Tetsuichi , Aoki Kosuke , Fujii Yoichi , Nannya Yasuhito , Makishima Hideki , Pfitzner Berit Maria , Bullinger Lars , Hirata Masahiro , Jinnouchi Keita , Shiraishi Yuichi , Chiba Kenichi , Tanaka Hiroko , Miyano Satoru , Okamoto Takeshi , Haga Hironori , Ogawa Seishi , Damm Frederik 
Published: April 2022

AbstractMyxofibrosarcoma (MFS) is a rare subtype of sarcoma, whose genetic basis is poorly understood. We analyzed 69 MFS cases using whole‐genome (WGS), whole‐exome (WES) and/or targeted‐sequencing (TS). Newly sequenced genomic data were combined with additional deposited 116 MFS samples. WGS identified a high number of structural variations (SVs) per tumor most frequently affecting the TP53 and RB1 loci, 40% of tumors showed a BRCAness‐associated mutation signature, and evidence of chromothripsis was found in all cases. Most frequently mutated/copy number altered genes affected known disease drivers such as TP53 (56.2%), CDKN2A/B (29.7%), RB1 (27.0%), ATRX (19.5%) and HDLBP (18.9%). Several previously unappreciated genetic aberrations including MUC17, FLG and ZNF780A were identified in more than 20% of patients. Longitudinal analysis of paired diagnosis and relapse time points revealed a 1.2‐fold mutation number increase accompanied with substantial changes in clonal composition over time. Our study highlights the genetic complexity underlying sarcomagenesis of MFS.
Special issue “The advance of solid tumor research in China”: Prognosis prediction for stage II colorectal cancer by fusing computed tomography radiomics and deep‐learning features of primary lesions and peripheral lymph nodes
Authors: Li Menglei , Gong Jing , Bao Yichao , Huang Dan , Peng Junjie , Tong Tong 
Published: April 2022

AbstractCurrently, the prognosis assessment of stage II colorectal cancer (CRC) remains a difficult clinical problem; therefore, more accurate prognostic predictors must be developed. In our study, we developed a prognostic prediction model for stage II CRC by fusing radiomics and deep‐learning (DL) features of primary lesions and peripheral lymph nodes (LNs) in computed tomography (CT) scans. First, two CT radiomics models were built using primary lesion and LN image features. Subsequently, an information fusion method was used to build a fusion radiomics model by combining the tumor and LN image features. Furthermore, a transfer learning method was applied to build a deep convolutional neural network (CNN) model. Finally, the prediction scores generated by the radiomics and CNN models were fused to improve the prognosis prediction performance. The disease‐free survival (DFS) and overall survival (OS) prediction areas under the curves (AUCs) generated by the fusion model improved to 0.76 ± 0.08 and 0.91 ± 0.05, respectively. These were significantly higher than the AUCs generated by the models using the individual CT radiomics and deep image features. Applying the survival analysis method, the DFS and OS fusion models yielded concordance index (C‐index) values of 0.73 and 0.9, respectively. Hence, the combined model exhibited good predictive efficacy; therefore, it could be used for the accurate assessment of the prognosis of stage II CRC patients. Moreover, it could be used to screen out high‐risk patients with poor prognoses, and assist in the formulation of clinical treatment decisions in a timely manner to achieve precision medicine.
Analysis of stock markets risk spillover with copula models under the background of Chinese financial opening
Authors: Du Jiangze , Chen Xizhuo , Gong Jincheng , Lin Xiao , Lai Kin Keung 
Published: April 2022

AbstractThis article adopts the new point of view on dynamic time‐varying based research, combined with the Copula and CoVaR model, to analyse the risk spillover effect of mainland China, Hong Kong and the US stock markets as well as the multi‐dimensional formation mechanism from the perspective of macroeconomic variables (VXFXI, EER, EPU and Liquidity) using TVP‐VAR‐SV and impulse response model. First, we find that the constructed copula models can address the asymmetry of stock market systemic risk spillover and the characteristics of co‐movement with better tail dependence estimation. Second, there is an obvious risk spillover effect between the Shanghai Composite Index (SSEC) and Shenzhen Component Index (SZEC). Due to the development of two connect programs, systemic risk can spread quickly from the Hang Seng Index (HSI) to SSEC and SZEC. Third, since the structure and participants of Chinese stock market, all macroeconomic variables make strongly positive and significant nonlinear impact on ΔCoVaR and exhibit significant non‐symmetric characteristics in the long‐ and short‐term perspectives, especially for EPU. These results indicate that strengthening the interconnections among systemically global stock markets is of important practical significance. Also, regulators should pay more attention on the policy uncertainty between economic and financial policy released time and lag 4‐month period.
Investigation of water substitution at RuII complexes by conceptual density function theory approach
Authors: Ćoćić Dušan , Petrović Biljana , Puchta Ralph , Chrzanowska Marta , Katafias Anna , van Eldik Rudi 
Published: April 2022

AbstractIn this paper, we investigated water exchange reactions and substitution of aqua RuII complexes of general formula [Ru(terpy)(N^N)(H2O)]2+ (where N^N = ethylenediamine (en), 1,2‐(aminomethyl)pyridine (ampy) and 2,2′‐bipyridine (bipy)) by ammonia and thioformaldehyde. These reactions were studied in detail by applying conceptual density functional theory. This approach enabled us to gain further insight into the underlying reaction mechanism at the microscopic level (involving only direct participants of the reaction, without the influence of the solvent) and to put the concept of reaction mechanism on a quantitative basis. The course of the chemical reaction along the reaction coordinate ξ, is rationalized in terms of reaction energy, force, dipole moment, and reaction electronic flux (REF). The results yield and characterize the significant influence of an intermolecular hydrogen bond formed between the entering and the spectator ligand to the overall energy barrier of the reactions.
Utility and safety of the self‐expandable metallic colonic stent in Japanese patients who received systemic chemotherapy or palliative treatment for obstructive primary advanced colorectal cancer: A retrospective single‐center medical chart evaluation
Authors: Naruse Naomi , Miyahara Koichi , Sakata Yasuhisa , Takamori Ayako , Ito Yoichiro , Hidaka Hidenori , Sameshima Ryuichiro , Tsuruoka Nanae , Shimoda Ryo , Yamanouchi Kohei , Noda Takahiro , Fujimoto Kazuma , Esaki Motohiro 
Published: April 2022

AbstractBackground and AimThe present study aimed to compare the utility and safety of the colonic self‐expandable metallic stent between patients with obstructive primary colorectal cancer who underwent chemotherapy or palliative treatment care and patients bridging for surgery.MethodsThe cases of 71 patients with colonic obstructive stenosis and in‐dwelling stents who were hospitalized between May 2012 and April 2020 at Karatsu Red Cross Hospital were retrospectively analyzed. The patients were classified into three groups: bridging for curative surgery (group I), receiving systemic chemotherapy (group II‐A), and receiving only palliative treatment (group II‐B). Technical and clinical success rates and complication rates after stenting were evaluated.ResultsNo significant differences were observed in the technical (procedure) success rates (group I: 100%; group II, 97.6% [II‐A: 100%; II‐B: 95.8%]). The total clinical success rate was 85.9% (61/71) and did not vary significantly among the groups (group I: 82.8%; group II 88.0% [II‐A: 83.3%; II‐B: 91.6%]). No significant differences were observed in the early complication rates between groups I and II and in the late complication rates between groups II‐A and II‐B. Nutrition status, general condition, tumor staging, and 1‐year survival were poorer in group II than in group I.ConclusionThe findings show that colonic stenting for malignant obstruction was performed successfully and safely both in patients who received systemic chemotherapy or palliative therapy and in patients bridging for curative surgery, regardless of risk status for malnutrition, poor general condition, cancer stage progression, and short survival.
Hyperspectral Raman imaging and multivariate statistical analysis for the reconstruction of obliterated serial numbers in polymers
Authors: Skokan Lilian , Ruediger Andreas , Muehlethaler Cyril 
Published: May 2022

AbstractAs recent years have shown an increasing use of polymers for the fabrication of firearms, it is necessary to develop techniques for the reconstruction of obliterated serial numbers that are stamped in these materials. Hyperspectral Raman imaging has proven to be a suitable technique for this purpose, as it is sensitive to residual strain. The extraction of relevant information however requires an advanced two‐step fitting procedure (i.e., the identification of strain‐sensitive peaks followed by the fitting itself) that may be somewhat time consuming. In this study, principal component analysis (PCA), an exploratory method of the Raman data, is proposed to overcome this deficit. The results show that PCA offers better visual contrast in comparison to the previously reported mathematical modeling technique, as it is able to highlight pertinent variance in the original dataset, for multiple polymers, such as polycarbonate, polyethylene, nylon, and nylatron. Results obtained by limiting acquisition times and spectral ranges have displayed no significant loss of information and therefore reconstruction abilities in polyethylene. A normal density function model and receiver operating characteristic (ROC) curves have been used to show that score matrices obtained from PCA are suitable for separation of distinct strained and unstrained pixel populations. Additionally, binary images favoring minimization of the false positive rate are created to enhance observable contrast allowing for easier character recognition. Finally, a recommended routine analysis is offered to forensic scientists wanting to apply these methods in order to aid criminal investigations or trials.
Organic material additions have stronger effects on humic substances and enzyme activities than soil types
Authors: Jin Shengai , Ma Hongbin , Jia Long , Liu Xinwei , Hussain Qaiser , Song Xiangyun , Cui Liqiang , Wang Chengji , Cui Dejie 
Published: April 2022

AbstractThe incorporation of organic materials derived from plant biomass into various soils is an effective strategy for increasing soil organic carbon (SOC). The comparative effect of organic material forms and soil types on carbon (C) sequestration has received little attention. On a C equivalent basis, wheat straw, wheat straw‐biochar, tobacco straw, and tobacco straw‐biochar were added to different soil types such as acidic, saline, and calcareous and incubated for 180 days. The structural characteristics of SOC, humic substance (HS) contents, and enzyme activities were investigated, and it was discovered that the C content of crop straws and biochar was primarily fixed in the form of humin (HU) in all soil types. Furthermore, biochar application did not increase humic acid (HA), whereas crop straws treatments did. Between HU and SOC, there was a significant positive correlation. SOC Aryl C was increased by biochar treatments, whereas phenolic C and O‐alkyl C were increased by straw treatments. Aromatic C correlated positively with SOC concentration, whereas polyphenol oxidase activity correlated positively with O‐alkyl C. The activity of polyphenol oxidase influenced the ormation of O‐alkyl C significantly. The majority of SOC functional groups and enzyme activities were found to have significant relationships with HS contents (pvalue <0.05). These findings suggest that both soil types and organic materials influence HS and functional groups of SOC, with organic materials having a stronger influence on microbial activity than soil types. Biochar can be used for a wide range of soils to not only store more recalcitrant C but also make SOC more hydrophobic.
Thermodynamics and Structure–Property Relationships of Charged Block Polymers
Authors: Grim Bradley J. , Green Matthew D. 
Published: April 2022

AbstractAdvancements in electronics and energy storage and conversion technologies brings with it myriads of exciting material design challenges. Charge‐containing block polymers (BPs) offer unique features which can overcome some of these challenges and have thus aroused substantial interest within the field of designer soft materials. The properties of BPs are intricately coupled to the dynamic and rich nature of the nanostructured assemblies, which result from the phase separation between blocks. The introduction of strong secondary forces, such as electrostatics and hydrogen bonding (H‐bonding), into BPs greatly influences their self‐assembly behavior, and therefore affects their physical and electrochemical properties often in nontrivial ways. In this review, some of the prevailing research, which has expanded the understanding of structure–property relationships to include several design strategies for improving ionic conductivity and modulus in charged block polymers, is presented. The profound extent to which electrostatics and hydrogen bonding impact block polymer thermodynamics, an extent which is demonstrated by recent theoretical and experimental work, is also highlight. Insights gained from the research presented here help to lay the groundwork for a long and bright future in the field of advanced soft materials.