bluuebunny/crossref_metadata_2025_split huggingface dataset:
Local cryotherapy on the pancreas with pancreatic necrosis: Results of the experimental study
Authors: Maskin S. S. , Aleksandrov V. V. , Petrenko S. A. , Igolkina L. A. 
Published: March 2022

Background. Acute pancreatitis retains its leading position in the structure of urgent abdominal pathology, maintaining a high postoperative mortality, despite the emergence of new methods of surgical treatment.The aim of the study: to evaluate pathomorphological changes in the pancreas, surrounding organs and tissues, clinical manifestations in dynamics after local cryotherapy on the pancreas in animals with experimental pancreatic necrosis for subsequent use of the method in clinical practice.Material and methods. An experimental study was performed on Wistar rats, in the main group, pancreatic necrosis was simulated with subsequent cryotherapy, in the control group, pancreatic necrosis was simulated and simple pancreatic mobilization was performed, in the third group, cryotherapy was performed on an unchanged gland. With the help of modern statistical methods, the effectiveness and safety of cryotherapy techniques were evaluated.Results. The optimal duration of cryoapplication is an interval of 3–4 seconds at a temperature of –195.75 °C, it is not accompanied by the formation of a cryonecrosis zone, promotes the regeneration of acinuses, does not damage the accumulation of endocrine cells, interrupting the course of pancreonecrosis, does not lead to a fatal outcome, a pronounced adhesive process, other serious intraabdominal complications.Conclusion. Cryotherapy on the pancreas in experimental pancreatic necrosis in the optimal temperature-time regime is accompanied by significantly lower mortality, is a safe technique and can be tested in clinical practice for the treatment of patients with this pathology.
Experimental hyperthermia: expression of proteins involved in the regulation of ovarian corpus luteum apoptosis in the acute and recovery periods
Authors: Michurina S. V. , Kolesnikov S. I. , Ishchenko I. Yu. , Arkhipov S. A. 
Published: March 2022

Background.Heat shock effects can initiate apoptosis of oocytes and corpus luteum cells in mammalian ovaries. During folliculogenesis, follicular apoptosis is regulated by Bcl-2 and BAX proteins which are key effectors of granular cell death. Mechanisms of disruption of the ovarian corpus luteum development under heat stress remain largely unclear.Aim of the research: to identify the expression features of anti-apoptotic Bad and proapoptotic Bcl-2 proteins in the rat ovarian luteocytes in the acute (by day 3) and recovery (by days 7 and 14) periods after a single exposure of experimental hyperthermia (EH) (rectal temperature 43.5 °C).Materials and methods. The expression of Bad and Bcl-2 was determined immunohistochemically using an indirect two-stage streptavidin-biotin method.Results. On day 3 after EH, the expression areas of both Bad and Bcl-2 increased 2-fold, but the ratio of Bcl-2/Bad areas did not change, indicating that the intensity of apoptosis along the mitochondrial pathway in luteocytes in the acute period was maintained within physiological values. On day 7, the Bad and Bcl-2 expression areas remained at the level of day 3, but the Bcl-2/Bad index decreased, indicating the activation of the apoptosis internal pathway in the ovarian corpus luteum cells. By day 14, the protein expression areas decreased (Bad – by 1.7 times, Bcl-2 – by 3.2 times) compared to the acute period, and the Bcl-2/Bad index decreased by 2 times compared to the control and the acute period group.Conclusion. The observed predominance of proapoptotic Bad protein over antiapoptotic Bcl-2 in luteocytes on day 14 after EH indicates the anti-apoptotic protection violation, which leads to the apoptosis mitochondrial pathway activation of the latter. A decrease in Bcl-2 expression can be regarded as a manifestation of the defective luteocytes removal mechanism and the body’s desire to normalize the ovarian-uterine cycle disrupted by high temperature exposure.
Influence of substrate wood species on the formation of antiviral properties of <I>Inonotus rheades</I> Pers. P. Karst. (1882) mycelium extracts regarding tick-borne encephalitis virus
Authors: Khasnatinov M. A. , Gornostai T. G. , Solovarov I. S. , Polyakova M. S. , Danchinova G. A. , Borovskii G. B. 
Published: March 2022

Background. The tick-borne encephalitis virus (TBEV) is one of the most dangerous and epidemiologically significant vector-borne pathogens. There is a need for effective antiviral agents for the treatment and prevention of this infection. Previously we found that the mycelium of Inonotus rheades grown on birch wood contains water-soluble substances with strong virulicidal properties against TBEV. It is necessary to check whether the mycelium of I. rheades can synthesize virulicidal substances from wood of other species.The aim: to study the antiviral properties of extracts of I. rheades mycelium grown on coniferous wood, both in the presence and in the absence of blue light during cultivation.Materials and methods. The mycelium of I. rheades was grown on birch, pine, and fir wood. The direct virulicidal effect of the extract was evaluated by the decrease in the titer of the infectious virus incubated in the presence of the extract. The ability of the extract to inhibit the reproduction of the virus in infected cells was studied by the calculation of 50 % effective concentration (EC50). The toxicity of extracts for cells was evaluated based on the calculation of 50 % cytotoxic concentration.Results. Mycelium extracts grown on conifers under blue light do not cause a statistically significant decrease in the concentration of infectious TBEV (p = 0.2563). However, the BP10 extract (pine, blue light) inhibits TBEV reproduction in infected cells (EC50 = 0.28 ± 0.06 mg/mL). Toxicity for SPEV cell culture is low. In the extracts of conifers grown in the dark, no antiviral effect was found at all.Conclusions. The component composition and mechanism of the antiviral action of I. rheades extracts are determined by the species of the wood substrate. The most promising sources of new drugs in relation to TBEV appear to be extracts of I. rheades mycelium grown on birch and pine.
Studying of the anti-ischemic action of <I>Rhaponticum uniflorum</I> and <I>Serratula centauroides</I> dry extracts on a model of bilateral occlusion of the carotid arteries
Authors: Markova K. V. , Toropova A. A. , Razuvaeva Ya. G. , Olennikov D. N. 
Published: March 2022

The aim of the study to evaluate the anti-ischemic effect of Serratula centauroides and Rhaponticum uniflorum dry extracts for bilateral carotid artery occlusion.Materials and methods. The studies were carried out on 77 Wistar rats. Rh. uniflorum and S. centauroides dry extracts at doses 50, 100, 200 mg/kg were administered intragastrically for 14 days prior to bilateral occlusion of the carotid arteries. To assess the anti-ischemic effect of the investigated agents, the total mortality, the dynamics of survival, the survival time, the animals’ neurological status were determined using a modified McGraw scale and the brain hydration degree.Results. S. centauroides at a dose 200 mg/kg reduced the percentage of animals’ death by 2.8 times (p ≤ 0.05) compared with the control. Life expectancy in animals treated with S. centauroides at doses 100 and 200 mg/kg and Rh. uniflorum at dose 100 mg/kg increased by 46, 52 and 64 %, respectively, compared to the control. The neurological deficit lowest severity was observed in animals treated with S. centauroides at dose 200 mg/kg. The most pronounced statistically significant decrease in the brain hydration level was observed in animals treated with Rh. uniflorum at doses 100 and 200 mg/kg and S. centauroides at dose 100 mg/kg.Conclusion. S. centauroides and Rh. uniflorum dry extracts have an anti-ischemic effect in cerebral ischemia.
The role of hypoxia in the pathogenesis of congenital hyperplasia of blood vessels in the head and neck in children (literature review)
Authors: Bychkova I. Yu. , Abduvosidov Kh. A. , Abduvosidov V. V. 
Published: March 2022

To date, scientists have found that stress plays an important role in the formation of congenital malformations. It can be caused by the influence of negative environmental factors on the pregnant woman or by her own diseases. One of the consequences of stress is hypoxia. It can be acute and chronic, and can have a negative impact both during pregnancy and during childbirth. They also distinguish local and general hypoxia. The consequences of the negative impact of oxygen deficiency on the embryo and fetus can manifest itself both in utero and after birth, leading to various kinds of congenital malformations, diseases, and sometimes fetal death, or increase the risk of sudden infant death syndrome. Hyperplasia of blood vessels, the so-called children’s hemangiomas, develops both in utero, especially with chronic fetal hypoxia, and during childbirth. It develops due to insufficient blood supply and oxygen deficiency in various parts of the body, most often in the head and neck. In an embryo under conditions of hypoxia, tachycardia develops – with an increase in heart rate and, if it is ineffective, local vasodilation occurs. Only then, under the condition of continuing hypoxia, does an increase in the number of blood vessels develop. This often leads to the formation of hyperplasia of the blood vessels, the so-called children’s hemangiomas.This pathology is quite common, especially among fair-skinned children, which makes its study, in particular the factors that cause this pathology, relevant today.
Clinical and instrumental characteristics of various forms of vitelliform dystrophies occurring in adult patient
Authors: Matcko N. V. , Gatsu M. V. 
Published: March 2022

Background. Vitelliform dystrophies, first detected in adulthood, may create complications in diagnosis, especially with partial or almost complete destruction of vitelliform material, disguising as various types of macular pathology, such as central serous chorioretinopathy, age-related macular degeneration.The aim: to study the clinical and instrumental characteristics of the most common forms of vitelliform dystrophies occurring in adulthood.Materials and methods. Sixty eyes of adult patients with vitelliform dystrophies were included in the study. All patients underwent ophthalmologic examination including family history, best corrected visual acuity, biomicroscopy, and multimodal imaging including fundus photo, SD-OCT, OCT-A, BAF, FA, ICGA. After examination, the patients were divided according to various types of vitelliform dystrophies. The instrumental and diagnostic characteristics of the identified forms of vitelliform dystrophies were studied, taking into account the stage of the process, based on the analysis of clinical data, as well as the results of the most accessible non-invasive research methods, such as SD-OCT, OCT-A, BAF.Results. The average age of patients was 52.40 ± 20.62 years, there were 13 (43.3 %) women and 17 (56.7 %) men. In 96.67 % of cases, the disease was bilateral. Genetically determined forms of vitelliform dystrophies were more common in sporadic forms. In the studied cohort, 43.3 % were patients with Best vitelliform macular dystrophy, 13.3 % – with autosomal recessive bestrophinopathy, 43.3 % – with pattern dystrophies. In all patients, according to structural OCT data, neuroepithelium detachment, residual vitelliform material in the form of massive deposits, deposits in the form of “stalactites”, “fringes” were determined. In all cases of vitelliform dystrophies, atrophic changes were detected, which intensified with an increase in the duration of the disease. Hyperautofluorescence of the residual vitelliform material in the form of “beads” was often accompanied in the later stages of the disease.Conclusion. Cases of vitelliform dystrophies identified in adults with partially resorbed vitelliform material require a thorough analysis of structural optical coherence tomography and fundus autofluorescence.
Perancangan Sistem Monitoring Konsumsi Daya Listrik Berbasis Android
Authors: Kurniawan Edi , Pangaudi Dwi Songgo , Widjatmoko Eko Nugroho 
Published: March 2022

Tagihan penggunaan listrik kepada sebagian pelanggan listrik pasca bayar tidak sesuai dengan daya listrik yang digunakan. Salah satu penyebab hal tersebut adalah tidak ada penghuni rumah ketika dilakukan pencatatan meteran oleh petugas sehingga petugas mencatat penggunaan daya listrik berdasarkan rata – rata penggunaan sebelumnya. Dengan permasalahan tersebut maka dibuat suatu sistem yang dapat memonitor penggunaan daya listrik pelanggan listrik dari jarak jauh. Monitoring jarak jauh dilakukan dengan memanfaatkan perkembangan teknologi mengenai Internet of Think (IoT) sehingga penggunaan daya listrik dapat dilihat kapanpun dan dimanapun melalui jaringan internet. Hasil penelitian menunjukkan sistem dapat mengirimkan data ke aplikasi Blynk melalui jaringan internet. Rata – rata error yang dihasilkan untuk pembacaan tegangan 0,043 % sedangkan rata – rata error pembacaan arus listrik adalah 6,25% dan rata – rata error daya listrik 6,71%. Error pembacaan arus listrik disebabkan karena tingkat ketelitian alat ukur yang digunakan sebagai pembanding hanya 1 angka dibelakang koma sedangkan error daya listrik karena error arus listrik. Berdasarkan data tersebut maka sistem ini sangat cocok untuk digunakan sebagai monitoring konsumsi daya listrik karena error yang dihasilkan cukup kecil, dan dapat dilakukan monitoring dari manapun dan kapanpun.
Studi Pembagian Beban Dan Rekonfigurasi Switching Keypoint Pada Jaringan TM 20 KV PWI – 7 GI Purwodadi Berbasis ETAP 12.6.0
Authors: Juniyanto Alfin 
Published: March 2022

Abstrak - Penyulang PWI 7 merupakan salah satu dari penyulang Jaringan Tegangan Menengah ( JTM ) 20 kV milik PT PLN (Persero) UP3 Demak pada Gardu Induk (GI) Purwodadi dengan wilayah mensuplai listrik tiga wilayah yang cukup jauh di Kabupaten Grobogan, Jawa Tengah, yaitu kecamatan Pulokulon, Kradenan, Gabus. Dimana penyulang ini memiliki kepadatan beban sebesar 400,33 A ( beban menjelang malam ) dengan pembatas OCR ( Over Current Relay ) dari PMT PWI 7 sebesar 450 A. Dari sisa 12 % dari beban penuh, penyulang PWI 7 hanya menampung sedikit jika membantu manuver penyulang disekitarnya serta jarak saluran yang jauh yaitu 62,94 kms, sehingga nilai tegangan ujung sangat rendah.Pada studi penelitian ini, menjabarkan perencanaan pembagian beban sepanjang ± 50% struktur jaringan penyulang lama PWI 7 dengan penambahan penyulang baru KRN 1. Pola pembagian struktur jaringan tersebut juga merubah pola switching keypoint sehingga perlu merekonfigurasi koordinasi proteksi pengaturan OCR ( Over Current Relay ) dan GFR ( Grount Fault Relay ) antara penyulang PWI 7 dengan penyulang baru KRN 1. Dengan didukung aplikasi simulasi ETAP 12.6.0 sebagai implementasi analisa dan penentuan pembagian beban dan rekonfigurasi switching keypoint dapat diterapkan di lapangan yang sesuai dengan Kajian Kelayakan Operasi ( KKO )
Penerapan Wahana Terbang Tanpa Awak untuk Memprediksi Waktu Panen pada Lahan Pertanian Berbasis Pengolahan Citra Digital
Authors: Pratama Rizqi Agung 
Published: March 2022

Pemanfaatan wahana terbang tanpa awak atau drone hingga saat ini telah banyak digunakan pada bidang pertanian antara lain untuk penyemprotan pestisida, pemetaan lahan, hingga memprediksi waktu panen. Penelitian ini menghadirkan hasil prediksi waktu panen untuk pertanian padi. Selama ini petani mengetahui padi yang siap panen hanya melalui fisik tanaman padi seperti tanaman padi mulai menguning, tangkai padi menunduk dan butir padi terasa keras apabila ditekan. Jadi harus diusahakan rekayasa yang dapat membantu memberikan data berupa estimasi waktu panen. Tahapan penelitian ini dimulai dari pengambilan citra pada lahan pertanian menggunakan drone. Drone juga dilengkapi dengan GPS yang nantinya akan digunakan untuk memperkirakan ukuran lahan pertanian. Kemudian citra tersebut akan dikirimkan menuju laptop. Pada laptop akan dilakukan proses ekstraksi fitur yaitu fitur warna, fitur bentuk dan fitur tekstur. Kemudian nilai-nilai ekstraksi fitur tersebut akan dijadikan data latih dan data uji. Dalam proses klasifikasi penelitian ini menggunakan algoritma SVM(support vector machine), K-Nearest Neighbor dan Multi Layer Perceptron. Hasil yang didapatkan algoritma Multi Layer Perceptron memiliki performa paling baik dengan rerata tingkat akurasi sebesar 84%, rerata precission sebesar 0,85, rerata recall sebesar 0,83 dan rerata F1 score sebesar 0,84. Setelah itu hasil klasifikasi akan di simpan pada Google Spreadsheet sebagai database untuk Bot Telegram.
Muutosagentit näköalapaikalla sosiaali- ja terveyspalvelujen uudistuksessa
Authors: Hoppania Hanna-Kaisa 
Published: March 2022

Vanhuspalveluita on pitkään määrittänyt tavoite purkaa ja vähentää raskasta laitoshoitoa ja siirtää palvelujen painopiste kotihoitoon ja ennaltaehkäisyyn. Tätä muutosta edisti myös Sipilän hallituksen I&O-kärkihanke (2016-2018), jossa myös pyrittiin kehittämään yhdenvertaisempia palveluita ja hillitsemään kustannusten kasvua. Taustalla oli näkemys, että palvelujärjestelmä on pirstaleinen eivätkä rakenteet olleet uudistuneet kansallisten tavoitteiden mukaisesti. Minkälaiset tekijät sitten edistävät tai jarruttavat muutoksen tekemistä? Artikkeli pureutuu sosiaali- ja terveyspalvelujen uudistamiseen ”muutosagenttien” ainutlaatuisesta näkökulmasta. Näiden viranhaltijoiden tehtävänä oli edistää ikäihmisten hoidon ja kotihoidon rakenteellista muutosta maakunnissa vuosina 2016-2018. Artikkeli kuvaa hanketta, jossa agentit työskentelivät ja analysoi tekijöitä, jotka agenttien mukaan vaikuttivat uudistuksen edistämiseen. Aineiston muodostavat 18 asiantuntijahaastattelua. Analyysissa hyödynnetään Nancy Fraserin markkinaistumisen, sosiaaliturvan ja emansipaation teoreettista kehystä. Esiin nousee vanhuspalvelujen kentän haasteita ja kunnallispolitiikan usein näkymättömäksi jääviä asioita, jotka vaikuttavat kansallisten vanhustenhoitoon liittyvien politiikkatavoitteiden saavuttamiseen. Erityisesti korostuu neljä tekijää: ICT-järjestelmien kehittäminen, kulttuurisen ja asennemuutoksen vaatima aika, valta- ja resurssikamppailut sekä kansallisen tason ohjauksen sitovuus.
Studi Eksploratif Tentang Sentra Jamu Tradisional Di Daerah Istimewa Yogyarta Sebagai Daya Tarik Wisata Kesehatan
Authors: Hadi Wisnu 
Published: March 2022

Setiap aktivitas perjalanan wisatawan pasti ada yang memberi pengaruh pada orang lain dan pengaruh tersebut akan memberi keuntungan bagi wisatawan dan orang lain. Salah satunya adalah wisata Kesehatan dimana banyak yang mencari para wisatawan seperti mendatangi tempat tempat wisata yang dapat memberikan kekebalan tubuh disaa pandemi Covid-19 ini. Para wisatawan banyak tertarik dengan mengkonsumsi minuman herbal salah satunya dengan minum jamu tradisional. Banyak sentra-sentra jamu tradisional di Daerah Istimewa Yogyakarta seperti Gesikan, Kiringan dan Argomulyo yang menghasilkan produk jamu tradisional yang bisa menjadi andalan untuk dijual sebagai wisata Kesehatan dan pendidikan. Dengan metode penelitian deskriptif kualitatif peneliti melakukan kajian studi eksploratif tentang sentra jamu tradisional di Daerah Istimewa Yogyakarta sebagai daya tarik wisata kesehatan dengan mencari data primer berupa pustaka dan observasi sehingga hasil penelitian dianalisis bahwa aktivitas pengolahaan jamu tradisional di desa Kiringan dan Argomulyo di Kabupaten Bantul serta desa Gesikan di Kabupaten sudah dikembangkan menjadi wisata Kesehatan selama ini. Hal ini temuan di desa Kiringan di Bantul sudah dibuat paket wisata yang berhubungan dengan jamu tradisional dari membuat, mengolah serta mengemas kemudian ikut menikmati jamu tersebut. Kemudian di Argomulyo Bantul juga sudah dikemas dengan mendirikan Omah Jamu dimana wisatawan bisa ikut menikmati olahan jamu yang sudah dikemas lebih modern. Serta data di desa Gesikan olahan jamu juga dikembangkan menjadi minuman untuk jamuan di hotel sebagai minuman welcome drink saat wisatawan masuk ke hotel.
Semantic similarity based food entities recognition using WordNet
Authors: Butt Sahrish , Bakhtyar Maheen , Noor Waheed , Baber Junaid , Ullah Ihsan , Ahmed Atiq , Basit Abdul , Kakar M. Saeed H. 
Published: March 2022

Unstructured text processing is the first step for several applications such as question answering systems, information retrieval, and recipe classification. In the field of recipe classification, number of frameworks have been proposed. However, it is still very tedious and time consuming to extract the food items from the unstructured text and then process for classification. In this research, an automatic food item detection from unstructured text is proposed based on semantic sense modeling. The candidate nouns are detected which can be food items and then the similarity of those nouns is computed with possible food categories. The candidate noun is treated as food item if the similarity is high. For similarity between possible food item and food category is computed by WordNet ontology. The proposed framework is evaluated on benchmark datasets and competitive performance have been achieved. The F-score on large dataset that contains around 20 K recipes is 0.89 which is improved from 0.56.
Minimizing pressure inhomogeneities across large samples under helium pressure media at low temperatures
Authors: Leão Juscelino Batista 
Published: March 2022

When using gas pressure media to achieve hydrostatic pressure under a constant pressure and volume, passing through the melting curve ([Formula: see text]) of the gas to achieve low temperatures (1.5 K ⩽ T < 30 K) will cause an overall pressure reduction at base temperatures of at most 25 percent of the pressure read while under hydrostatic conditions at the [Formula: see text]. In-situ inert gas high pressure vessels for neutron scattering for pressures of up to 1.0 GPa and temperatures as low as 1.5 K pose a particular problem due to the [Formula: see text] phase diagram of the pressure media. A methodology for pressurization to ensure minimal pressure loss as temperature falls below the pressure media phase change, at the same time minimizing pressure inhomogeneity throughout the length of the sample; as well as calibration data are presented within this work.
Intrinsic motivation for using a wearable hip exoskeleton
Authors: Roggeman Stijn , Firouzi Mahyar , Lefeber Nina , De Keersmaecker Emma , Cuypers Lotte , Swinnen Eva , Joos Erika , Schiltz Marc , Hatem Samar M. 
Published: March 2022

BACKGROUND: Walking difficulties put an individual at high risk of falling, institutionalisation and even death. The use of robotical rehabilitation or assistive devices for walking has gained considerable interest as a means of improving patients’ gait abilities. OBJECTIVE: The aim of this research was to examine patients’ intrinsic motivation to train with a wearable hip exoskeleton (Honda Walking Assist). METHODS: Rehabilitation patients (stroke, medullar lesion, orthopaedic surgery) and elderly ([Formula: see text] 65 yrs) with walking difficulties were recruited for this study ([Formula: see text] 23). Each walked with the Honda Walking Assist for 30 minutes during one therapy session and completed the Intrinsic Motivation Inventory (IMI) afterwards. RESULTS: All participants presented with high scores on the IMI, in particular for the items ‘interest/enjoyment’ (median: 43; 25[Formula: see text]–75[Formula: see text] perc.: 37–46; maximal score: 49), ‘perceived competence of walking’ (35 [31–38]; max. score 42) and ‘value/usefulness’ (44 [35–49]; max. score 49). CONCLUSIONS: This robotic exoskeleton for assisted walking was considered a valuable device by the majority of participants, eliciting a high degree of motivation and enjoyment.