bluuebunny/crossref_metadata_2025_split huggingface dataset:
Synthesis and anti-influenza virus activity evaluation of novel andrographolide derivatives
Authors: Zou Chunyang , Men Jinyu , Qu Yingjin , Jiang Chunfeng , Wang Yao , Chen Lixia , Yuan Lei 
Published: June 2022

Abstract
In this paper, using AI78-38, an andrographolide analog with novel skeleton, as the lead compound, we designed and synthesized fifteen amide derivatives at the 17 position of AI78-38. In the synthesis of key intermediate IM4, the low yield of the SeO2 oxidation step impeded the further study. Aiming at improving the yield, White reagent was applied to furnish IM4 by catalyzing the allylic C–H oxidation at the 7, 8, 17 position. It is also firstly reported that White reagent possessed the ability of oxidating the cyclic substrates. Compared with SeO2 oxidative approach, the modified synthetic method utilized by White reagent increased the yield from 32.0% to 53.6%. The anti-influenza A virus (H3N2) results showed that 4-methoxy derivative 10 offered the greatest inhibitory ability, with an IC50 value of 90.2 mg/ml, slightly more potent than ribavirin. Furthermore, the drug likeness and ADMET properties of compound 10 and AI78-38 were evaluated using the Discovery Studio 2.1 software and the online SwissADME. The results showed that compound 10 offered good bioavailability and overcame the disadvantages of the ADMET properties in AI78-38.
Efficacy of belimumab combined with rituximab in severe systemic lupus erythematosus: study protocol for the phase 3, multicenter, randomized, open-label Synbiose 2 trial
Authors: Schaik Mieke van , Arends Eline J. , Soonawala Darius , Ommen Ellen van , de Leeuw Karina , Limper Maarten , Paassen Pieter van , Huizinga Tom W.J. , Toes René E.M. , Kooten Cees van , Rotmans Joris I. , Rabelink Ton J. , Teng Y.K. Onno 
Published: June 2022

Abstract
Introduction: Belimumab, an anti-B-cell activating factor antibody, is approved for the treatment of auto-antibody positive systemic lupus erythematosus with a high degree of disease activity. Anti-CD20 B cell depletion with rituximab is used in refractory SLE as well, although with variable responses. We hypothesized that incomplete B cell depletion, related to a surge in BAFF levels following rituximab treatment, can cause ongoing disease activity and flares. The Synbiose 1 study primarily focused on immunological effects and shows preliminary clinical benefit of combined rituximab and belimumab in SLE. The Synbiose 2 study will evaluate the clinical efficacy of combining belimumab with rituximab in patients with severe SLE, allowing tapering of prednisolone and mycophenolate. Methods and analysis Synbiose 2 is a phase 3, multicenter, randomized, controlled, open-label two year clinical trial. Seventy adults with severe SLE including lupus nephritis will be randomized 1:1 to receive either standard of care consisting of prednisolone and mycophenolate as induction and maintenance treatment, or belimumab and rituximab combined with standard of care as induction treatment, followed by prednisolone and belimumab as maintenance treatment. The primary objective is to assess whether combined B cell therapy will lead to a reduction of treatment failure. Secondary endpoints are complete and partial clinical and renal response, and the improvement of SLE-specific autoimmune phenomena. Safety endpoints include the incidence of adverse events, with special interest in infections. Discussion The Synbiose 2 trial is the first multicenter phase 3 clinical trial investigating combined B cell targeted therapy in SLE, including lupus nephritis. The outcome of this study will provide further evidence for the clinical efficacy of this new treatment strategy in severe SLE. Trial registration Clinical Trials, NCT03747159, Registered November 20, 2018; https://clinicaltrials.gov/ct2/show/NCT03747159
A Comprehensive Analysis Revealing NEK2 as an oncogene in the Tumor Microenvironment
Authors: Jiang Lin-hong , Li Lei , Yang Kai , Wang Dan-dan , Xu Wen-xiu , Yang Su-jin , Chen Xiu , Tang Jin-hai , Zhang He-Da 
Published: June 2022

Abstract
Background
Never in Mitosis (NIMA)-related kinase 2 (Nek2), a member of the serine/threonine kinase family, localizes to centrosomes/kinetochores, which was involved in mitotic regulation. However, the clinical significance and the role of NEK2 in various cancers remained largely elusive.
Methods
ONCOMINE, Tumor Immune Estimation Resource (TIMER), Kaplan-Meier plotter database, UALCAN, GeneMANIA, String and CancerSEA Analysis were used to fully evaluate the clinical value of NEK2
Results
NEK2 was meaningfully up-regulated in the vast majority of cancers, however, the prognostic significance of NEK2 was only associated with the patients with breast cancer, lung cancer, liver cancer, renal carcinoma, pancreatic ductal adenocarcinoma, sarcoma and thyroid carcinoma. Furthermore, NEK2 expression was also correlated with individual pathological cancer stages. In addition, NEK2 participated in regulating the tumor immunity. Enrichment analysis and functional state showed NEK2 was involved in the cell cycle.
Conclusions
These findings interpret the clinic value of NEK2 in a variety of cancers, which may be a novel biomarker and therapeutic target.
Mid-term Evaluation of Maternal and Child Nutrition Programme (MCNP II) in Kenya
Authors: Codjia Patrick , Kutondo Edward , Kamudoni Penjani , Munga Judith , Ahluwalia Aneesha , Sharma Indrani , de Jong Yvon , Amolo Tom , Maina Lucy , Mwenda Victoria , Chaudhry Hemant , Bukania Zipporah 
Published: June 2022

Abstract
Background: Kenya is still facing a triple burden of malnutrition. Malnutrition in Kenya is multi-faceted in nature with health and socio-economic implications. Huge geographical disparities exist, especially, in the arid and semi-arid lands, further exacerbated by factors such as inadequate funding allocation to nutrition sector, challenges in multi-sectoral coordination and nutrition governance. UNICEF’s Maternal and Child Nutrition Program (MCNP II) is a four-year (2018-2022) resilience building, multi-sectoral program focused on pregnant and lactating women, mothers of children under five years and children under five years. The objective of this mid-term evaluation was to establish relevance, effectiveness, efficiency, and sustainability of the programme. Methods: The study adopted a concurrent mixed methods approach, where qualitative information was gathered through key informant interviews, focus group discussions and quantitative data obtained through desk review of secondary data from various sources. Qualitative information was organized using Nvivo software and analyzed thematically, while descriptive analysis for the quantitative data was undertaken using EXCEL software. Results: The findings show that MCNP II programme has aligned its efforts to the nutrition situation in Kenya as well as to the Government of Kenya and donor priorities. Most of the planned programme targets were achieved despite operating in COVID-19 pandemic environment. The use of approaches such as family mid-upper arm circumference (MUAC), integrated management of acute malnutrition (IMAM) surge model, Malezi bora and Logistic Management Information Management System have contributed to realization of results. Stringent financial management strategies contributed towards programme efficiencies; however, optimal utilization of the resources needs further strengthening. The programme has adopted strategies for strengthening local capacity and promote ownership.Conclusion: The programme is on track across the four evaluation criteria. However, a few suggestions are recommended to improve relevance, effectiveness, efficiency, and sustainability. A formal transition strategy needs to be developed in consultation with multi-stakeholder groups and implemented in phases. UNICEF can explore ‘Delivering as One approach’ and gender transformative approaches with more systematic involvement of males and females in gender-based discussions.
Contrast-enhanced MRI-based radiomics signatures as new markers for preoperative assessment of the EGFR mutation and subtypes from bone metastases
Authors: Fan Ying , Dong Yue , Sun Xinyan , Wang Huan , Zhao Peng , Wang Hongbo , Jiang Xiran 
Published: June 2022

Abstract
Background
To develop and externally validate contrast-enhanced (CE) T1-weighted MRI-based radiomics for the identification of epidermal growth factor receptor (EGFR) mutation, exon-19 deletion and exon-21 L858R mutation with the spinal bone metastasis from primary lung adenocarcinoma.
Methods
The study enrolled 159 patients from our hospital between Jan. 2017 and Sep. 2021 to form a primary set, and 24 patients from another center between Jan. 2017 and Oct. 2021 to form an independent validation set. Radiomics features were extracted from the CET1 MRI using the Pyradiomics method. The least absolute shrinkage and selection operator (LASSO) regression was applied for selecting the most predictive features. Radiomics signatures (RSs) were developed based on the primary training set to predict the EGFR mutation and to differentiate the exon-19 deletion and exon-21 L858R. The RSs were validated on the internal and external validation sets using the ROC curve analysis.
Results
A total of 8, 3 and 5 most predictive features were selected to build the RS-EGFR, RS-19 and RS-21 for predicting the EGFR mutation, exon-19 deletion and exon-21 L858R, respectively. The RSs generated favorable prediction efficacies on the primary (AUCs, RS-EGFR vs. RS-19 vs. RS-21, 0.851 vs. 0.816 vs. 0.814) and external validation (AUCs, RS-EGFR vs. RS-19 vs. RS-21, 0.807 vs. 0.742 vs. 0.792) sets.
Conclusions
Radiomics features from the contrast-enhanced MRI could be used to detect the EGFR mutation, increase the certainty of identifying exon-19 deletion and exon-21 L858R mutations based on the spinal metastasis.
Analysis of phase stability, elastic, electronic, thermal, and optical properties of Sc1-xYxN via ab initio methods
Authors: Gagui Souheyla , Meradji Hocine , Ghemid Sebti , Naeem Samia , Haq Bakhtiar Ul , Ahmed Rashid , Kushwaha A.k. 
Published: June 2022

Abstract
Understanding the physical properties of a material is crucial to know its applicability for practical applications. In this study, we investigate the phase stability, elastic, electronic, thermal, and optical properties of the ternary alloying of the scandium and yttrium nitrides (Sc1 − xYxN) for different compositions. To do so, we apply a “density functional theory (DFT)” based scheme of calculations named as “full potential (FP) linearized (L) augmented plane wave plus local orbitals (APW + lo) method" realized in the WIEN2k computational package. At first, the phase stability of the investigated compositions of the mentioned alloy is determined. The analysis of our calculations shows that Sc1 − xYxN alloy is stable in rock salt crystal structure for all investigated compositions. Next to that, the elastic properties of the rock-salt phase of the studied ternary alloy Sc1 − xYxN at all above said compositions were done at the level of “Wu-Cohen generalized gradient approximation (Wu-GGA)” within DFT. However, Trans-Blaha (TB) approximation of the “modified Becke-Johson (mBJ)” potential is also used in combination with Wu-GGA where the thermal properties are calculated at the level of the "quasi-harmonic Debye model". The obtained results for the absorption coefficients, and optical bandgap, represent that the title alloy may be a suitable candidate for the applications in optoelectronic devices.
Illumination system optimal design for geometry measurement of complex cutting tools in machine vision
Authors: Wang Wenqi , Liu Wei , Zhang Yang , Zhang Peidong , Si Likun , Zhou Mengde 
Published: June 2022

Abstract
Precision geometry measurement of the complex cutting tools has a significant impact on the machinability of components in the industry. However, acquisition of high-quality images in machine vision is a challenging problem due to the large slope and complex geometry of the cutting tools. In view of the vital function of illumination, this paper proposed a method of optimal design for the LEDs array. First, the calculation model of irradiance distribution on the measurement plane is established and the properties of the reflected light from the surface of cutting tools is analysed based on the BRDF theory. Then, the optimal parameters are solved through the specific algorithm flow for the LED array design. Finally, a flexible LED light source is fabricated with the optimal parameters for different features of the cutting tools and used in the measurement. The measurement results show that the error of the optimized light source is less than 1 \(%\) , and compared with the off-the-shelf light, the measurement accuracy is improved by 9.5$%$ on average. Moreover, this method also presents the potential applied in other complex objects.
Impact of Chocolate percutaneous transluminal angioplasty balloon on vessel preparation in drug-coated balloon angioplasty for femoropopliteal lesion
Authors: Shirai Shigemitsu , Mori Shinsuke , Yamaguchi Kohei , Mizusawa Masafumi , Chishiki Toshiki , Makino Kenji , Honda Yohsuke , Tsutsumi Masakazu , Hiraishi Mana , Kobayashi Norihiro , Yamawaki Masahiro , Ito Yoshiaki 
Published: June 2022

Abstract
Purpose: Compare the impact of Chocolate and conventional balloons on vessel preparation in percutaneous transluminal angioplasty.Materials and Methods:Study included 111 endovascular therapy consecutive cases of femoropopliteal lesions using drug-coated balloon strategy with a 1:1 pre-dilation balloon diameter between February 2020 and August 2021, divided into the Chocolate percutaneous transluminal angioplasty (n=48) and conventional (n=63) groups. Before the availability of Chocolate balloons in Japan (December 2020), a standard semi-compliant or non-compliant balloon was used for vessel preparation. Since its availability, Chocolate percutaneous transluminal angioplasty balloons are used. Primary endpoint was rate of severe dissection after pre-dilatation. Secondary endpoints were angiographic percent diameter stenosis, bailout stent rate, primary patency rate, and freedom from target-lesion-revascularization rate at six months.Results: There was no significant difference in patient and lesion characteristics. Procedural characteristics comprised balloon length 90±37 mm and 149±95 mm (P=0.004) and inflation pressure 11±3 atm and 16±7 atm (P<0.001) in the Chocolate and conventional groups, respectively. Regarding primary endpoint, rates of severe dissection were 4.2% and 25% (P=0.003); regarding secondary endpoints, percent diameter stenosis was 18±15% and 20±17% (P=0.409), and the rate of bailout stenting was 2.1% and 15.9% (P=0.016) in the Chocolate and conventional groups, respectively. Primary patency rates at six months were 89.1% and 85.2% (P=0.670), and freedom from target-lesion-revascularization rate at six months was 100% and 92.8% (P=0.691) in the Chocolate and conventional groups, respectively. Conclusion:Chocolate percutaneous transluminal angioplasty balloons reduce the rate of severe dissection while maintaining sufficient dilatation effect in drug-coated balloon vessel preparation.
Analysis of the risk factors of post-operative seizure in pediatric patients with hydrocephalus undergoing endoscopic third ventriculostomy
Authors: Wang Yubo , Liu Ying , Liu Yutong , Sun Peng , Liu Yang , Du Jianxin , Zeng Gao 
Published: June 2022

Abstract
Objective: The cause and mechanism of epilepsy after endoscopic third ventriculostomy (ETV) have still remained elusive. This single-center study aimed to explore and analyze the risk factors of post-operative seizure in pediatric patients with hydrocephalus undergoing ETV.Methods: Data of pediatric patients with hydrocephalus who were treated with ETV from October 1, 2015, to November 31, 2021, were retrospectively analyzed. Basic demographic characteristics, etiology of hydrocephalus, surgical details, and laboratory measurements were collected. An early postoperative seizure was defined as the occurrence of at least one clinical seizure within 24 h of ETV.Results: A total of 50 participants were included in the study, of whom 5 (10.00%) cases were in postoperative epilepsy group and 45 (90.00%) cases were in non-epilepsy group. Epilepsy patients were younger than those without epilepsy, while no statistically significant difference was found (P = 0.0836). In the age subgroup, children with epilepsy were younger than 2 years old. All patients with epilepsy received Ringer’s solution intraoperatively. The mean postoperative serum calcium and potassium concentrations were significantly lower in patients with epilepsy than in those without epilepsy (Pcalcium=0.0429; Ppotassium= 0.0250). Moreover, a faster decrease of serum potassium and calcium levels was found in children with epilepsy compared with those without epilepsy after ETV.Conclusion: The decrease of serum calcium and potassium levels, younger age, and using Ringer’s solution as irrigation fluid were risk factors for epilepsy after ETV.
Spread Characteristics of Supersonic Noncircular Jets
Authors: Kumar Indradeep , Kumar Manu , Mohanta PK 
Published: June 2022

Abstract
Various research studies on jet spread characteristics have been conducted on the non-circular supersonic jets. However, in these studies, the hydraulic diameter & shape factor of nozzle exit geometry has not been emphasized. The scope of the current investigation includes jet spreading behavior, jet half-width, and axis switching phenomena. This investigation used various types of a nozzle like square, hexagon, elliptical, triangular, circular, and rectangular with divergent and convergent length and throat area ratios are the same. The results ascertained that the hydraulic diameter should be smaller for faster jet mixing. The principal, minor, and diagonal characteristics dimension of hydraulic diameter plays a significant role in spread characteristics. The mixing contribution is lower in circular jets compared to rectangular jets. The distance between the ambient lip and nozzle exit lip plays a vital role at the nozzle exit for mass entertainment.
Tissue paper‑based composite separator using double-crosslinked polymer electrolyte as coating layer for lithium ion battery with superior ion transport and cycle stability
Authors: Hu Yuqin , Zhu Guobin , Zeng Xinyu , Wang Cheng , Xu Jing , Wang Luoxin , Wang Hua 
Published: June 2022

Abstract
Non-woven based battery separators have been developed rapidly in recent years due to their unique advantages in process, cost and performance. In this study, a novel double-crosslinked three-dimensional network coating was constructed by hyperbranched polyethyleneimine (PEI), Polydimethylsiloxane diglycidyl ether (PDMSDGE) and poly(vinylidene fluoride-co-hexafluoropropylene) PVDF-HFP. Then the caoting used to modify tissue paper, which composed of packed cellulose fibers is typical nonwoven with excellent hydrophilic properties required for lithium separators. As we expected, the composite separator shows unique advantages in terms of porosity, electrolyte absorption, mechanical properties and thermal stability. At the same time, the nucleophilic hyperbranched PEI in the coating makes the composite separator in a lithium-rich state in lithium ion battery, so the separator has a certain electric pumping capacity by electrokinetic surface conduction and electroosmosis. As a result, the electrochemical performance and battery performance are excellent too. In addition, we compared the performance of the double-crosslinked coating with two systems of single-crosslinked coating, PEI/PDMSDGE and PEI/PVDF-HFP. The results showed the excellent performance of the composite separator with double-crosslinked coating in terms of mechanical properties retention (95.05%) after electrolyte infiltration and discharge capacity retention (86.89%) after 200 cycles, which given by the stable molecular structure of the three-dimensional double-crosslinked network.
Analysis of high-risk factors for severe Mycoplasma pneumoniae pneumonia associated with plastic bronchitis
Authors: Ma Yuting , Guo Wei , Han Chunjiao , Jin Peng , Wei Diwei , Xu Yongsheng , Zhan Jianghua 
Published: June 2022

Abstract
Background: Plastic bronchitis (PB) is a severe disease with rapid progression and high mortality, and its incidence is increasing. This study created and validated a diagnostic and predictive nomogram based on clinical characteristics to improve the diagnosis of PB in clinical practice.Methods: This randomized, controlled, retrospective, observational study evaluated 447 children with severe Mycoplasma pneumoniae pneumonia, including 147 children with PB (intervention group) and 300 without PB (control group). Independent diagnostic predictors of PB were identified by multivariate logistic regression analysis and area under the receiver operating characteristic curve (AUC≥0.70), and a diagnostic model with six independent clinical characteristics was developed. The performance of the nomogram was assessed using the C-index, calibration curves, and decision curve analysis.Results: Fever duration, neutrophil percentage, lactate dehydrogenase, procalcitonin, interleukin-6, and pleural effusion were independent risk factors for PB and were included in the nomogram. The C-index of the nomogram was 0.900 (95% CI: 0.866–0.934), indicating an excellent ability to discriminate between patients with and without PB. The calibration curve showed good agreement between the predicted and actual probability. The net reclassification improvement(NRI) was 0.1803 (95% CI: 0.0039–0.3567; p=0.0451), and the integrated discrimination improvement(IDI) was 0.1755 (95% CI: 0.1004–0.2505; p<0.001). Decision curve analysis(DCA) showed that the nomogram was clinically useful for detecting PB.Conclusions: We constructed and validated a diagnostic and predictive nomogram with six independent risk factors for PB. The proposed nomogram can improve the early diagnosis of this complication in clinical practice.
Equivalent chassis-based model predictive control for three-axle trucks during tire blowout on expressway
Authors: Fang Chao , Yue Ming , Shangguan Jinyong , Guo Lie 
Published: June 2022

Abstract
Unexpected tire blowout on expressway is one of the most dangerous scenarios for heavy load multi-axle trucks, especially under the inexperienced driver's improper intervention. To this end, this paper proposes an autonomous tire blowout controller for three-axle trucks based on model predictive control (MPC) method. First of all, aiming at balancing the computing load and the path tracking accuracy, an equivalent chassis is transformed based on the stable two-dimensional vehicle dynamic model. Secondly, a tire blowout oriented vehicle high-fidelity dynamic model is established based on the equivalent chassis, in which the vehicle lateral, yaw and roll motion are all considered at the same time. Then, an MPC-based dynamic control strategy is proposed to achieve effective tire blowout suppression with consideration of vehicle rollover stability. Afterwards, a transient vertical tire force shock is employed to simulate the real tire blowout behavior, upon which two typical scenarios are constructed based on the TruckSim/Simulink co-simulation platform. The simulation results illustrate the feasibility and effectiveness of the proposed method.