bluuebunny/crossref_metadata_2025_split huggingface dataset:
Materials with Tunable Optical Properties for Wearable Epidermal Sensing in Health Monitoring
Authors: Han Fei , Wang Tiansong , Liu Guozhen , Liu Hao , Xie Xueyong , Wei Zhao , Li Jing , Jiang Cheng , He Yuan , Xu Feng 
Published: March 2022

AbstractAdvances in wearable epidermal sensors have revolutionized the way that physiological signals are captured and measured for health monitoring. One major challenge is to convert physiological signals to easily readable signals in a convenient way. One possibility for wearable epidermal sensors is based on visible readouts. There are a range of materials whose optical properties can be tuned by parameters such as temperature, pH, light, and electric fields. Herein, this review covers and highlights a set of materials with tunable optical properties and their integration into wearable epidermal sensors for health monitoring. Specifically, the recent progress, fabrication, and applications of these materials for wearable epidermal sensors are summarized and discussed. Finally, the challenges and perspectives for the next generation wearable devices are proposed.
Protein‐Encoding Free‐Standing RNA Hydrogel for Sub‐Compartmentalized Translation
Authors: Ahn So Yeon , Kim Jeonghun , Vellampatti Srivithya , Oh Sung , Lim Yong Taik , Park Sung Ha , Luo Dan , Chung Junho , Um Soong Ho 
Published: March 2022

AbstractRNA can self‐fold into complex structures that can serve as major biological regulators in protein synthesis and in catalysis. Due to the abundance of structural primitives and functional diversity, RNA has been utilized for designing nature‐defined goals despite its intrinsic chemical instability and lack of technologies. Here, a robust, free‐standing RNA hydrogel is developed through a sequential process involving both ligation and rolling circle transcription to form RNA G‐quadruplexes, capable of both catalytic activity and enhancing expression of several proteins in sub‐compartmentalized, phase‐separated translation environments. The observations suggest that this hydrogel will expand RNA research and impact practical RNA principles and applications.
Low‐Profile Planar Antenna Sensor Based on Ti3C2Tx MXene Membrane for VOC and Humidity Monitoring
Authors: Khorsand Kazemi Kasra , Hu Shujun , Niksan Omid , Adhikari Kishor Kumar , Tanguy Nicolas Roland , Li Shibo , Arjmand Mohammad , Zarifi Mohammad H. 
Published: March 2022

AbstractDetection of volatile organic compounds (VOC)s is of great interest in industrial and environmental applications due to the severe impact of VOCs on human health and the environment, including climate change and ozone layer depletion. This study investigates the implementation of a Ti3C2Tx MXene as radiating and sensing element to develop a VOC and humidity sensing antenna. The performance of the sensor is validated by introducing various VOCs, including acetone, ethanol, IPA, and methanol, in an isolated custom‐made chamber while the antenna sensor is communicating with a distanced receiver antenna. Measured results confirm that the exposure of the MXene antenna sensor to VOCs causes an upshift in the operating frequency of the antenna sensor. The study successfully demonstrates the potential of the proposed Ti3C2Tx MXene antenna sensor in detecting acetone concentrations ranging from 8 to 80 parts per thousand (ppt). In addition, the sensor detects different humidity concentrations ranging between 77.8 ± 2% to 94 ± 1%, where for 94 ± 1% of humidity, a 213.1 MHz of frequency shift is observed. As a proof of concept, the developed MXene antenna sensor shows a promising potential for wireless gas and humidity sensing applications in the environmental and industrial sectors.
Development of an NAD(H)‐Driven Biocatalytic System for Asymmetric Synthesis of Chiral Amino Acids
Authors: Cheng Feng , Zhang Jia‐Min , Jiang Zhen‐Tao , Wu Xiao‐Hu , Xue Ya‐Ping , Zheng Yu‐Guo 
Published: March 2022

AbstractChiral amino acids are extensively applied in the pharmaceutical, food, cosmetic, and agricultural industries. As a representative example, l‐phosphinothricin (l‐PPT, a chiral non‐natural amino acid) is a broad‐spectrum herbicide. An NAD(H)‐driven biocatalytic system for the asymmetric synthesis of chiral amino acids (focused on l‐PPT) with high efficiency and low cost is highly desired. The key for the development of such biocatalytic system is to obtain an NADH‐dependent biocatalyst with high catalytic performance toward l‐PPT pro‐ketone PPO. Herein, an engineered glutamate dehydrogenase from Lysinibacillus composti (LcGluDH) with desired activity was obtained by gene mining and protein engineering. In silico analyses suggested that the volume of substrate‐binding pocket was substantially enlarged from 330.5 Å3 to 409.6 Å3. The stability of LcGluDH was increased (Tm value increased from 47.3 °C to 65.3 °C) by introducing positively charged amino acids or aromatic amino acids at position 375. The desired biocatalytic system was constructed by coupling the engineered LcGluDH and an NAD+‐dependent FDH. Through this biocatalytic system, the batch production of l‐PPT exhibited high space‐time yield (207.3 g ⋅ L−1 ⋅ day−1) with strict stereoselectivity (ee of l‐PPT>99%). Furthermore, eight other chiral amino acids were synthesised by the developed NAD(H)‐driven biocatalytic system with high ee values.magnified image
A Proton‐Barrier Separator Induced via Hofmeister Effect for High‐Performance Electrolytic MnO2–Zn Batteries
Authors: Yuan Yuan , Yang Jinlong , Liu Zaichun , Tan Rui , Chuai Mingyan , Sun Jifei , Xu Yan , Zheng Xinhua , Wang Mingming , Ahmad Touqeer , Chen Na , Zhu Zhengxin , Li Ke , Chen Wei 
Published: March 2022

AbstractElectrolytic MnO2–Zn batteries with economic advantages and high energy density are viable candidates for large‐scale energy storage. However, the spontaneous reactions between acidic electrolytes and Zn metal anode cause severe proton‐induced hydrogen evolution which is difficult to avoid. Herein, a proton‐barrier separator (PBS) based on poly(vinyl alcohol) (PVA) is fabricated via the Hofmeister effect for preventing hydrogen evolution. Experiments and theoretical calculations demonstrate that the concentrated sulfate enables PVA chains to form a discontinuous hydrogen bond network as well as isolated hydrophilic cavities. This unique feature can effectively obstruct proton migration to impede proton‐induced hydrogen evolution, but allow for fast Zn2+ transfer with excellent stability. Electrolytic MnO2–Zn batteries with PBS deliver high energy retention (91.2% after 200 cycles) and largely enhanced rate performance (20 C) in a high areal capacity of 6.67 mAh cm−2 with a very low cost ($1 m−2) as compared to commercial anion exchange membranes (8 C). This work sheds light on new avenues for the development of stable electrolytic MnO2–Zn batteries by deploying PBS for preventing hydrogen evolution through a cost‐effective fabrication method, which is a universal approach that can be applied to design other stable aqueous metal‐ion batteries.
Catalytic Asymmetric β‐Oxygen Elimination**
Authors: Matt Christof , Orthaber Andreas , Streuff Jan 
Published: March 2022

AbstractA catalytic enantioselective β‐O‐elimination reaction is reported in the form of a zirconium‐catalyzed asymmetric opening of meso‐ketene acetals. Furthermore, a regiodivergent β‐O‐elimination is demonstrated. The reaction proceeds under mild conditions, at low catalyst loadings, and produces chiral monoprotected cis‐1,2‐diols in good yield and enantiomeric excess. The combination with a Mitsunobu reaction or a one‐pot hydroboration/Suzuki reaction sequence then gives access to additional diol and aminoalcohol building blocks. A stereochemical analysis supported by DFT calculations reveals that a high selectivity in the hydrozirconation step is also important for achieving high enantioselectivity, although it does not constitute the asymmetric step. This insight is crucial for the future development of related asymmetric β‐elimination reactions.
Rhodium‐NHC‐Catalyzed gem‐Specific O‐Selective Hydropyridonation of Terminal Alkynes
Authors: Galiana‐Cameo María , Romeo Raúl , Urriolabeitia Asier , Passarelli Vincenzo , Pérez‐Torrente Jesús J. , Polo Victor , Castarlenas Ricardo 
Published: March 2022

AbstractThe dinuclear complex [Rh(μ‐Cl)(η2‐coe)(IPr)]2 is an efficient catalyst for the O‐selective Markovnikov‐type addition of 2‐pyridones to terminal alkynes. DFT calculations support a hydride‐free pathway entailing intramolecular oxidative protonation of a π‐alkyne by a κ1N‐hydroxypyridine ligand. Subsequent O‐nucleophilic attack on a metallacyclopropene species affords an O‐alkenyl‐2‐oxypyridine chelate rhodium intermediate as the catalyst resting state. The release of the alkenyl ether is calculated as the rate‐determining step.
Highly efficient flame retardant and smoke suppression mechanism of polypropylene nanocomposites based on clay and allylamine polyphosphate
Authors: Xiao Dan , Zheng Meng‐Ting , Gohs Uwe , Wagenknecht Udo , Voit Brigitte , Wang De‐Yi 
Published: March 2022

AbstractFire‐retarded polymer nanocomposites (FRPN) based on polypropylene with clay and allylamine polyphosphate (PP/clay‐AAPP) were designed and prepared by melt mixing. Their morphological, thermal and fire‐safety properties were investigated by TEM, SEM, EDS, TG, UL‐94, LOI, cone‐calorimeter test and TG‐FTIR. The results exhibited that the LOI of PP/2 wt%clay‐20wt%AAPP nanocomposites was 29.5% with V‐0 rating level in UL‐94 vertical testing. Significant enhancements in fire safety performance were also observed for fire‐retarded PP nanocomposites from cone‐calorimeter test decreasing heat release as well as smoke and toxic gases. PP/clay‐AAPP nanocomposites not only provided relatively stable char layer during polymer burning, but also exhibited better fire safety performance due to the exfoliation of clay platelets. It displayed that incorporation of clay and AAPP were very efficient in increasing the fire safety of PP composites.
The transnational in‐between identity of Chinese student returnees from the UK: Mobility, variations and pathways
Authors: Wang Suyang 
Published: March 2022

AbstractConsidering the rising tide of international student return mobility, the UK needs to pay attention to the long‐term circulation and development of international student returnees. This study analyses the mobility, variations and pathways of the transnational in‐between identity of Chinese student returnees from the UK, an under‐researched group in the changing dynamics of international student mobility. This longitudinal study uses original data from 48 semi‐structured interviews to show how student returnees’ identities change over time in transnational sociocultural contexts. This study develops a spider chart comprising multiple manifestations of transnational selves to account for returnees’ intermediary and heterogeneous states of transnational in‐between identities. Based on the empirical evidence, the study finds that transnational in‐between identity is characterised by a ‘self‐in‐between mobility’, seeking compromises and connections between the polar extremes of essentialist and non‐essentialist approaches to identity. In such an identification process, the changing dynamics of agency play a pivotal role in (re)shaping multiple identity pathways as variegated temporal outcomes of mobility. The findings not only advance the theoretical and methodological constructs of identity, but also have implications for relevant concerns in international education.
Das neue DBV‐Merkblatt „BIM‐Prozessqualität“
Authors: Bastert Heinrich , Meyer Julian , Orf Matthias 
Published: March 2022

AbstractMit dem neuen DBV‐Merkblatt „BIM‐Prozessqualität“ erweitert der DBV seine umfangreiche Merkblattsammlung. Ziel des neuen DBV‐Merkblatts ist die Darstellung praxistauglicher Planungsstrukturen als Handlungsempfehlungen für die Hochbauplanung mit Building Information Modeling (BIM). Dazu gehört vor allem bereits zu Projektbeginn die Etablierung geeigneter Arbeitsabläufe und ‐bedingungen für die Einbindung von BIM als Grundlage für die Beauftragung von Planungsleistungen. Ein wesentlicher Schwerpunkt des DBV‐Merkblatts liegt in der Tragwerksplanung als einer zentralen Planungsdisziplin mit zahlreichen Schnittstellen zu anderen Planungsdisziplinen und diversen Planableitungen, z. B. für die Haustechnikgewerke. Viele der für die Tragwerksplanung vorgestellten Empfehlungen zu geeigneten Projektstrukturen sind allgemeingültig und auf die übrigen Planungsdisziplinen übertragbar. Darüber hinaus werden die aus Sicht der Tragwerksplanung besonderen Anforderungen an die Arbeitsweise mit BIM dargestellt. Der vorliegende Bericht stellt die wichtigsten Inhalte des neuen DBV‐Merkblatts vor und erläutert beispielhaft die praktische Umsetzung anhand des Ablaufs bzw. von Einzelaspekten für ein Hochbauprojekt.
Realisierung der neuen AirportAcademy auf dem LabCampus am Münchner Flughafen
Authors: Sonderegger Eric , Beliaev Dmitrii , Lorber Stefan , Ott Markus , Uhl Hubert 
Published: March 2022

AbstractAm neuen LabCampus auf dem Gelände des Flughafens München plant und erstellt die Ed. Züblin AG als Generalübernehmerin den Neubau des Trainingszentrums AirportAcademy für die LabCampus GmbH. Besonders bautechnisch herausfordernd ist das tragende außen liegende Betonfachwerk über zwei Geschosse. Das Tragwerk folgt von der Formgebung her den Start‐ und Landebahnen des Flughafens und ist umlaufend ohne jegliche Dilatationsfugen ausgeführt. Über seitlich anschließende Stahlverbundträger und die aufgehenden Fassadenpfeiler unterstützt das Betonfachwerk die darüberliegenden Geschosse. Neben zahlreichen Interaktionen in der Tragwerksfindung und ‐planung in Kombination mit hoch beanspruchten Knotenpunkten stellt der Anspruch einer gleichbleibenden Ästhetik des später um den kompletten Gebäudeumfang sichtbaren Außentragwerks eine besondere Herausforderung an das Schalungssystem und an den Betonbau dar.
Semiparametric marginal methods for clustered data adjusting for informative cluster size with nonignorable zeros
Authors: Shen Biyi , Chen Chixiang , Chinchilli Vernon M. , Ghahramani Nasrollah , Zhang Lijun , Wang Ming 
Published: March 2022

AbstractClustered or longitudinal data are commonly encountered in clinical trials and observational studies. This type of data could be collected through a real‐time monitoring scheme associated with some specific event, such as disease recurrence, hospitalization, or emergency room visit. In these contexts, the cluster size could be informative because of its potential correlation with disease status, since more frequency of observations may indicate a worsening health condition. However, for some clusters/subjects, there are no measures or relevant medical records. Under such circumstances, these clusters/subjects may have a considerably lower risk of an event occurrence or may not be susceptible to such events at all, indicating a nonignorable zero cluster size. There is a substantial body of literature using observations from those clusters with a nonzero informative cluster size only, but few works discuss informative nonignorable zero‐sized clusters. To utilize the information from both event‐free and event‐occurring participants, we propose a weighted within‐cluster‐resampling (WWCR) method and its asymptotically equivalent method, dual‐weighted generalized estimating equations (WWGEE) by adopting the inverse probability weighting technique. The asymptotic properties are rigorously presented theoretically. Extensive simulations and an illustrative example of the Assessment, Serial Evaluation, and Subsequent Sequelae of Acute Kidney Injury (ASSESS‐AKI) study are performed to analyze the finite‐sample behavior of our methods and to show their advantageous performance compared to the existing approaches.
Erbium(III) ion‐doped borate‐based glasses for 1.53 μm broad band applications
Authors: Nayab Rasool Shaik , Shabeena Shaik , Kesavulu Culala Rajasekharaudayar , Babu Singarapu , Mohan Babu Asanapuram , Venkatramu Vemula 
Published: March 2022

AbstractNovel erbium(III) ion‐doped borate‐based glasses (Er3+:BCNF) by conventional melt‐quenching technique were designed and synthesized. The glasses were characterized for their structural, vibrational and spectroscopic properties. The nephelauxetic ratio, bonding parameters, and Judd–Ofelt (JO) intensity parameters (Ωλ λ = 2, 4 and 6) were determined by using absorption spectrum of 1 mol% Er2O3 doped glass. These JO parameters were utilized to derive radiative properties for various excited states of erbium(III) ions. Emission cross‐section for 4I13/2 → 4I15/2 transition of erbium(III) ions was computed through McCumber theory. The decay curves for (2H11/2, 4S3/2) and 4I13/2 levels were recorded and analysed. All the results of Er3+:BCNF glasses revealed that the studied glasses are efficient and thermally stable and could be suitable for display devices, optical amplification and green laser applications.
A Comparative Study of Chemical Profiling and Biological Effects ofDoronicum orientaleExtracts
Authors: Zengin Gokhan , Mahoomodally Mohamad Fawzi , Sinan Kouadio Ibrahime , Bakar Kassim , Jugreet Sharmeen , Yildiztugay Evren , Angeloni Simone , Mustafa Ahmed M. , Caprioli Giovanni 
Published: March 2022

AbstractIn this study, phytochemical and pharmacological screening of the aerial part and roots extracts fromDoronicum orientaleHoffm. (Asteraceae) was carried out. Plant extracts were obtained using solvents of different polarity (hexane, ethyl acetate, ethanol, ethanol/water, water) for selection the most optimal solvent for the extraction of active compounds. For instance, the extracts yielded total phenolic and flavonoid contents in the range of 12.13–45.67 mg GAE/g and 0.75–12.44 mg QE/g, respectively, while the total antioxidant capacity of the extracts determined by the phosphomolybdenum assay ranged from 0.88–2.53 mmol TE/g. HPLC/MS/MS analysis revealed 5‐caffeoylquinic acid (2.52–337.05 μg/g) and 3,5‐dicaffeoylquinic acid (3.12–299.36 μg/g) to be the major components present in the investigated extracts. Antioxidant activity in terms of radical scavenging ability of the extracts ranged from 0.82–45.56 mg TE/g in DPPH assay and from 5.07–104.58 mg TE/g in ABTS assay. The tested extracts were found to inhibit acetylcholinesterase (aerial part: 0.50–2.33 mg GALAE/g; roots: 0.40–2.43 mg GALAE/g), while with the exception of the water extracts, the other extracts showed butyrylcholinesterase inhibition (aerial part: 2.46–5.02 mg GALAE/g; root: 2.93–4.17 mg GALAE/g). Overall, this study presented an interesting scope of this species in phytomedicine with preliminary data demonstrating some of the tested extracts to possess high bioactive contents, antioxidant potential and enzyme inhibitory activity. Thus, additional investigations are necessary to confirm their safety in herbal drug applications.
Mammalian target of rapamycin (mTOR) signaling pathway and traumatic brain injury: A novel insight into targeted therapy
Authors: Movahedpour Ahmad , Vakili Omid , Khalifeh Masoomeh , Mousavi Pegah , Mahmoodzadeh Amir , Taheri‐Anganeh Mortaza , Razmeh Saeed , Shabaninejad Zahra , Yousefi Fatemeh , Behrouj Hamid , Ghasemi Hassan , Khatami Seyyed Hossein 
Published: March 2022

AbstractTraumatic brain injury (TBI) is one of the most concerning health issues in which the normal brain function may be disrupted as a result of a blow, bump, or jolt to the head. Loss of consciousness, amnesia, focal neurological defects, alteration in mental state, and destructive diseases of the nervous system such as cognitive impairment, Parkinson's, and Alzheimer's disease. Parkinson's disease is a chronic progressive neurodegenerative disorder, characterized by the early loss of striatal dopaminergic neurons. TBI is a major risk factor for Parkinson's disease. Existing therapeutic approaches have not been often effective, indicating the necessity of discovering more efficient therapeutic targets. The mammalian target of rapamycin (mTOR) signaling pathway responds to different environmental cues to modulate a large number of cellular processes such as cell proliferation, survival, protein synthesis, autophagy, and cell metabolism. Moreover, mTOR has been reported to affect the regeneration of the injured nerves throughout the central nervous system (CNS). In this context, recent evaluations have revealed that mTOR inhibitors could be potential targets to defeat a group of neurological disorders, and thus, a number of clinical trials are investigating their efficacy in treating dementia, autism, epilepsy, stroke, and brain injury, as irritating neurological defects. The current review describes the interplay between mTOR signaling and major CNS‐related disorders (esp. neurodegenerative diseases), as well as the mTOR signaling–TBI relationship. It also aims to discuss the promising therapeutic capacities of mTOR inhibitors during the TBI.
Linkage‐Specific Synthesis of Di‐ubiquitin Probes Enabled by the Incorporation of Unnatural Amino Acid ThzK
Authors: Zhou Han , Carpenter Tomaya , Fu Xuan , Jin Bo , Ody Britton , Hassan Mohammad Sazid , Jacobs Savannah E. , Cheung Jenny , Nicholson Eve M. , Turlington Mark , Zhao Bo , Lorenz Sonja , Cropp T. Ashton , Yin Jun 
Published: March 2022

AbstractDi‐ubiquitin (diUB) conjugates of defined linkages are useful tools for probing the functions of UB ligases, UB‐binding proteins and deubiquitinating enzymes (DUBs) in coding, decoding and editing the signals carried by the UB chains. Here we developed an efficient method for linkage‐specific synthesis of diUB probes based on the incorporation of the unnatural amino acid (UAA) Nϵ‐L‐thiaprolyl‐L‐Lys (L‐ThzK) into UB for ligation with another UB at a defined Lys position. The diUB formed by the UAA‐mediated ligation reaction has a G76C mutation on the side of donor UB for conjugation with E2 and E3 enzymes or undergoing dethiolation to generate a covalent trap for DUBs. The development of UAA mutagenesis for diUB synthesis provides an easy route for preparing linkage‐specific UB‐based probes to decipher the biological signals mediated by protein ubiquitination.
Can hypoosmotic shock and calcium influx lead to translocation of aquaporin‐1 in shrimp muscle cells?
Authors: Foguesatto Kamila , Lopes Fernanda Moreira , Boyle Robert Tew , Nery Luiz Eduardo Maia , Souza Marta Marques 
Published: March 2022

AbstractThe physiological variations during the crustacean molting cycle have intrigued researchers for many years. Maintaining osmotic homeostasis in the face of hemolymph dilution and dealing with dynamic intracellular and extracellular calcium fluctuations are challenges these animals continuously confront. It has recently been shown that water channels present in the cell membrane (aquaporins) are essential for water uptake during premolt and postmolt. This study aims to investigate whether hypoosmotic shock and intracellular and extracellular calcium variations can lead to translocation of Aquaporin 1 (AQP‐1) from the intracellular region to the plasma membrane during premolt and postmolt, thus allowing increased water flow in these stages. For this, we investigate in vitro the rapid change of AQP‐1 positions in the abdominal muscle cells in the freshwater shrimp, Palaemon argentinus. Using cell volume analysis and immunohistochemistry, we show that hypoosmotic conditions and an elevation of the intracellular and extracellular calcium concentrations are concurrent with the translocation of AQP‐1 to the plasma membrane. These results indicate that calcium flux and hypoosmotic shock may be regulators of AQP 1 in the translocation process.