bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessment of groundwater suitability for irrigation in coastal-arid zone (Tunisian SE) using Analytic Hierarchy Process (AHP), GIS tools and water quality index
Authors: Abdelkarim Bilel , Telahigue Faten , Abaab Nabil , Boudabra Belgacem , Agoubi Belgacem 
Published: May 2022

Abstract
In southern Tunisia especially in Gabes region, Irrigated agriculture is the major economic sector. The intensive exploitation of groundwater have been gradually rising, leading the water quality to deteriorate. To ensure sustainable development and preserve water, soil and land cover resources, a careful estimation of the irrigation water quality, which influence on the regional agriculture activities. The objective of this study is to investigate the irrigation water suitability based on hydrogeological; hydrochemical and analytic hierarchy approach (AHP) and water quality index (WQI). Results highlighted that TDS of the groundwater ranged from 0.4 to 7 g/L. The most abundant chemical species in the water were Ca2+, Cl−, SO42−, and Na+, with mean concertation of 460mg/l, 1320 mg/l, 1450 mg/l and 1200mg/L, respectively. The largest amounts were discovered along the shoreline and in deep aquifers embedded in cretaceous sediments. AHP has used as multicriteria decision analysis, to weighting groundwater quality criteria, and groundwater suitability for irrigation has been mapped. Based on the Quality index “WQI” the water samples are categorized into three types: excellent, acceptable, and worthless. A 45% of sampled water is not suitable for irrigation use. However, groundwater quality is increasingly poor towards the coastal areas and north of the study area. This study concluded that the method adopted in assessing the groundwater quality in arid coastal areas led to important results and could be helpful scholar to improve their research especially in similar areas. It can also assist decision makers in taking proactive solutions to protect and preserve groundwater resources from pollution risks.
Evaluation of home-based Naturopathic Telehealth clinic: an innovative model implemented in response to the COVID-19 pandemic
Authors: Shew Tracelee , Smith Catherine , Connolly Greg , McLachlan Craig 
Published: May 2022

Abstract
ObjectivesThe COVID-19 pandemic in Australia disrupted usual clinical training placements for naturopathic students. An innovative, remote Telehealth model was developed and implemented. This pilot study evaluates student and educator learning and teaching experiences in Telehealth. A survey assessed Likert and qualitative written responses to student and staff interaction with the Telehealth clinic. ResultsNine student and 12 educator responses were included in the analysis. All students positively rated Telehealth training resources and the educator support provided. Students rated the Telehealth learning experience as ‘very good’ (78%) or ‘good’ (22%) with educator ratings of ‘very good’ (67%) or ‘good’ (33%). Thematic analysis of student written responses showed increased client diversity, collaboration, peer learning, increased feedback, and improved digital and technology skills. Virtual physical examination and infrastructure limitations were reported as Telehealth clinical practicum challenges.Naturopathic Telehealth clinic practicum is a valuable alternative to in-person clinical practicums for Australian students. It enhances student collaboration and peer learning. Challenges of technology, infrastructure and incorporating Telehealth in curriculum may be barriers to implementation of Telehealth. However, Telehealth is an important clinical training option to prepare student practitioners for contemporary professional practice if in-person consultation is prohibitive, such as during the COVID-19 pandemic.
PLAGL2 Is a Prognostic Biomarker in Stomach cancer：A Comprehensive Study Based on Bioinformatics and Experiments
Authors: Wang Lin , Yan Li , Zhou Zili 
Published: May 2022

Abstract
Background：Polymorphic adenoma-like protein 2 (PLAGL2), a zinc finger protein, has been linked to the advancement of serval-type malignancies. However, the relevance of PLAGL2 to the prognosis and regulatory networks of different cancers remains unclear. Methods：The expression of PLAGL2 was explored through Oncomine, TIMER and SangerBox websites. The relationship between PLAGL2 expression and prognosis in various cancers was analyzed through the Kaplan-Meier Plotter database and the PrognoScan databases. The expression of PLAGL2 in several immunological and molecular subtypes of human cancer was evaluated through the TISIDB database. The differentially expressed genes associated with PLAGL2 was explored through LinkedOmics database. The relationship between PLAGL2 expression and clinicopathological features in STAD was explored through the UALCAN database. The expression of PLAGL2 in STAD specimens was analyzed through western blot and IHC. The function of PLAGL2 in STAD was explored through the CCK8 test and the colony formation test. Results：In this study we found that PLAGL2 was overexpressed in most types of cancer and overexpression of PLAGL2 might predicted a poor prognosis in STAD. Next, we investigated PLAGL2 expression in several immunological and molecular subtypes and found that PLAGL2 expression differs considerably across immunological subtypes and molecular subtypes of most cancer types. Our research also shows that the expression of PLAGL2 is correlated with various immunostimulatory and immunosuppressive cytokines. We also analyzed the PLAGL2 co-expression network, and evaluated the prognostic potential of genes positive co-expression with PLAGL2 in STAD through Kaplan-Meier plotter. The results show that most of co-expression genes have a significant effect on the prognosis. We further designed experiments to explore the function of PLAGL2 in STAD. Consistent with previous studies, PLAGL2 was significantly overexpressed in STAD tissues compared with that of adjacent normal tissues. And PLAGL2 can promote the proliferation of STAD cells both in vivo and in vitro. Conclusions: Our findings showed that data mining successfully identifies PLAGL2 expression and putative regulatory networks in STAD, laying the groundwork for additional research into the function of PLAGL2 in carcinogenesis.
A combination of Granulocyte-macrophage colony-stimulating factor with the R2 regimen in elderly high-risk B cell lymphoma maintenance therapy improves survival by modulating natural killer cells
Authors: Sun Shunrong , fulati Wulipan , Shen Lin , Wu Min , Huang Zilan , Qian Wensi , Chen Pingping , Hu Yingwei , Chen Mingyue , Xu Yu , Zhang Hongdi , Ma Jiexian , Xie Yanhui 
Published: May 2022

Abstract
Background
The clinical outcome of B-cell lymphoma has improved dramatically due to hematopoietic stem cell transplantation (HSCT) and biological agents. However, treatment of high-risk B cell lymphoma in the elderly remains a challenge because of their ineligibility for HSCT, high mortality and relapse rates. Maintenance therapy to improve the prognosis of B cell lymphoma in the elderly might be feasible.
Methods
We analyzed the efficacy of a combination of human recombinant granulocyte-macrophage colony-stimulating factor (rhGM-CSF) with the R2 regimen in maintenance therapy in high-risk B cell lymphoma in the elderly of our center. A total of 83 elderly patients, who were ineligible for auto-HSCT and had a response after 6 cycles of induction therapy above a partial response, were divided into two groups: observation (n = 44) and R2 + GM-CSF (n = 39) by enrollment time.
Results
The clinical data, survival outcome, and the number of peripheral blood mononuclear cells were analyzed and compared. The numbers of lymphocytes (1.19 × 109/L vs. 1.03 × 109/L, P = 0.0062) and leukocyte (6.46 × 109/L vs. 4.85×109/L, P = 0.0048) increased after receipt of maintenance therapy, particularly the number of natural killer cells (0.131 × 109/L vs. 0.061 × 109/L, P = 0.0244). Patients receiving R2 + GM-CSF for maintenance had longer-term remission (duration of response (DOR): 18.9 months vs. 11.3 months, P = 0.001), and longer-term progression free survival (PFS) (not reached (NR) vs. 31.7 months, P = 0.037), and overall survival (OS) (NR vs. NR, P = 0.015). The new R2 regimen was safe and well tolerated. The elderly, high-risk, and high tumor burden seemed to have tendency to be independent prognostic factors for a better PFS (P = 0.060, 0.012, 0.005).
Conclusions
The new R2 regimen prolonged progression-free survival and overall survival among elderly patients with high-risk B cell lymphoma, appeared to lead to improve response without compromising its tolerability profile in elderly patients who are ineligible to receive HSCT. The number of patients in this trial was limited and the conclusions should be verified in larger, prospective, multicenter studies.
Retrospectively registered:
The ethical committee of Huadong Hospital (approval number: 2021K186).
Experimental investigation on simultaneous machining of EDM and ECM of Ti6Al4V with different abrasive materials and particle sizes
Authors: Meng Jianbing , Wang Shuaike , Guan Qingyi , Dong Xiaojuan , Li Hongmei , Li Li , Zhao Guoyong , Zhao Yugang 
Published: May 2022

Abstract
In view of the difficult machining characteristics of titanium alloys and the limitations of EDM/ECM serial machining, a study of parallel machining of EDM and ECM with the aid of abrasive particles was carried out using a low conductivity NaNO3 salt solution as the working medium. Firstly, the influences of the electrical conductivity of working medium, abrasive material and abrasive particle size on material removal rate, electrode loss rate, surface roughness and surface microstructure were analyzed. Then, the material removal rate, electrode loss rate and surface roughness were taken as evaluation indexes, and the multi-process objectives were transformed into a single evaluation index by orthogonal test and grey correlation analysis. The optimal combination of the main process parameters including peak current, pulse width, abrasive particle concentration and gap voltage was obtained, and the experimental verification was carried out. The results show that under the same electrical parameters and machining conditions, the comprehensive machining effect is better when the conductivity of working medium is 300 µS/cm. Compared with Cu and Al abrasives, although SiC abrasives have the lowest material removal rate, the electrode loss rate and surface roughness are the smallest; according to the analysis of multi-objective grey correlation degree, the optimal combination of process parameters for EDM and ECM parallel machining assisted by SiC abrasive particles with particle size of 50 µm is as follows: peak current 1.5 A, pulse width 15 µs, abrasive concentration 5 g/L and gap voltage 40 V. Compared with other parameter combinations, the electrode loss rate, surface roughness and surface morphology are improved obviously under this parameter combination.
Clinical features and risk factors analysis for poor outcomes of severe community-acquired pneumonia (SCAP) in children: a nomogram prediction model
Authors: Xu Changjing , Tao Xuemei , Fu Liya , Zhu Junlong , Yang Xuping , Hou Chao , Liu Yujie , Zhu Wanlong , Huang Yilan 
Published: May 2022

Abstract
Background: Early prediction of poor outcomes (PO) is of great significance to the improvement of the longterm prognosis of children with a diagnosis of severe community-acquired pneumonia (SCAP).The study aimed to explore the risk factors for PO of SCAP in children. We further aimed to develop and validate a PO-predictive nomogram model for SCAP in children. Methods: A population-based, retrospective case-control study was conducted in children with a diagnosis of SCAP who were hospitalized in our hospital from August 1, 2018 to October 31, 2021. Based on the occurrence of poor outcomes (PO), children were divided into PO and the non-PO groups. The multivariate logistic regression model was used to construct the nomogram model. Results: A total of 300 children with a diagnosis of SCAP were included, and 56 children had PO. The results of multivariate logistic regression analysis revealed that the possible independent risk factors for PO were comorbidity and invasive mechanical ventilation (IMV). In internal validation, the model displayed good discrimination with a C-index of 0.866 (95% CI: 0.772~0.960) and high quality of calibration plots in the nomogram model was noted. Conclusions: The nomogram model presented good discrimination and calibration in estimating the risk of PO among pediatric patients with a diagnosis of SCAP.
A Context-Aware M-RIPPER Algorithm for Heart Disease Prediction
Authors: Almutairi Saad , S Manimurugan , Aborokbah Majed Mohammed , C Narmatha , Ganesan Subramaniam , AlzahebHani Riyadh A , Almoamari Hani 
Published: May 2022

Abstract
These days, mobile computing devices are ubiquitous and widely used in almost every facet of daily life. Computing and the modern world are not really coexisting anymore. With a wide range of conditions and areas of concern, the medical domain was also concerned. New types of technologies, such as context-aware systems and applications, are constantly being infused into the medicine field. An IoT-enabled healthcare system based on context awareness is developed in this work. In order to collect and store patient data, smart medical devices are employed. Context-aware data from the database includes the patient's medical records and personal information. The MRIPPER (Modified Repeated Incremental Pruning to Produce ErroR) technique is used to analyze and classify the data. A rule-based machine learning method is used in this algorithm. The rules for analyzing data sets in order to make predictions about heart disease are framed using this algorithm. MATLAB is used to simulate the proposed model's performance analysis. Other models like random forest, J48, CART, JRip, and OneR algorithms are also compared to validate the proposed model’s performance. The proposed model obtains 98.89 percent accuracy, 96.76 percent precision, 99.05 percent sensitivity, 94.35 percent specificity, and 97.60 percent f-score. Predictions for subjects in the normal and abnormal classes were both accurate with 97.38 for normal and 97.93 for abnormal.
Quantum Disordered Ground State in the Heisenberg-Kitaev Candidate NaRuO2
Authors: Ortiz Brenden , Sarte Paul , Avidor Alon Hendler , Hay Aurland , Kenney Eric , Kolesnikov Alexander , Aczel Adam , Brown Craig , Wang Chennan , Graf Michael , Seshadri Ram , Balents Leon , Wilson Stephen 
Published: May 2022

Abstract
The realization of spin liquid states born from the near-critical regime of the triangular lattice Hubbard model in inorganic materials remains a long-standing challenge, where weak spin-orbit coupling and other small perturbations often induce conventional spin freezing or order. Strong enough spin-orbit coupling, however, can renormalize the electronic wave function and induced anisotropic exchange interactions that promote magnetic frustration. Through the cooperative interplay of spin-orbit coupling and correlation effects, here we show that the triangular lattice magnet NaRuO2 hosts an inherently fluctuating magnetic ground state with thermodynamic properties suggestive of a crossover between dynamic ground states. Despite the presence of a charge gap, we find that low-temperature spin excitations generate a metal-like term in the specific heat and continuum excitations in neutron scattering, reminiscent of spin liquid states found in triangular lattice organic magnets. Further cooling reveals that these fluctuations crossover into a state whose dynamic spin autocorrelation function reflects persistent fluctuations within a highly disordered spin state. These findings instantiate NaRuO2 as a unique, Heisenberg-Kitaev cousin to organic, Heisenberg spin liquid compounds with a low-temperature crossover in quantum disorder driven via the interplay between geometric frustration, extended hopping, and relativistic spin-orbit coupling.
Psychosocial work stress and parent-child bonding during the COVID-19 pandemic: clarifying the role of parental symptoms of depression and aggressiveness
Authors: Koerber Mirjam I. , Mack Judith T. , Seefeld Lara , Kopp Marie , Weise Victoria , Starke Karla Romero , Garthus-Niegel Susan 
Published: May 2022

Abstract
Background: Parental work stress and impaired mental health seem to have intensified during the current COVID-19 pandemic. Both can have a negative impact on parent-child bonding: psychosocial work stress in the course of a spillover effect from work to family and symptoms of impaired mental health as part of a crossover effect from parent to child. This potentially affects the child's development in the long term.Method: This cross-sectional study examined the relationship between psychosocial work stress and parent-child bonding during the early COVID-19 pandemic (May–July 2020). Symptoms of depression and aggressiveness were considered as mediators of this relationship. The sample consisted of employees in Eastern Germany (n = 380; 42.9% mothers, 57.1% fathers), aged 24–55 years, with children aged 0–36 months. Results: After including potential confounders, higher psychosocial work stress predicted weaker parent-child-bonding (β = 0.148, p = .017, 95% CI [0.566, 5.614]). The older the child was (β = 0.123, p = .035, 95% CI [0.008, 0.209]) and the more a parent worked in home office (β = 0.127, p = .010, 95% CI [0.494, 3.562]), the weaker the parent-child bonding. When stratifying for parents’ sex, results showed that the more hours mothers worked (β = -0.252, p = .006, 95% CI [-0.340, -0.059]) and if they did not work in home office (β = 0.181, p = .018, 95% CI [0.536, 5.672]), the stronger the mother-child bonding, which was not true for fathers. Symptoms of depression predicted father-child bonding (β = 0.420, p < .001, 95% CI [0.470, 0.944]), but mother-child bonding was associated with the confounders higher number of hours worked (β = -0.215, p = .021, 95% CI [-0.315, -0.026]) and not working in home office (β = 0.154, p = .038, 95% CI [0.146, 5.167]) and not symptoms of depression. Symptoms of depression (ab = 2.491, 95% CI [1.472, 3.577]) as well as of aggressiveness (ab = 2.091, 95% CI [1.147, 3.279]) mediated the relationship between psychosocial work stress and parent-child bonding.Discussion: The results of this study highlight the importance of prevention as well as intervention measures in relation to psychosocial work stress that may play a debilitating role in the context of family relationships. In addition, the results suggest that both employers and employees should be made aware of the importance of psychosocial work stress, as it can have a negative impact on mental health, which in turn may have a major influence on family relationships. Since working in home office and the amount of hours at work seem to have a differential impact on mothers and fathers as well as on their family relationships, these aspects should be investigated in further research.
Complete genome analysis of a novel chuvirus from a southern green stink bug, Nezara viridula
Authors: Ren Peng-Peng , Ye Zhuang-Xin , Wang Sai-Nan , Chen Jian-Ping , Li Jun-Min , Zhang Chuan-Xi , Lu Jia-Bao 
Published: May 2022

Abstract
A novel chuvirus from the southern green stink bug (Nezara viridula) was identified by RNA sequencing in this study, which was named "Nbu southern green stink bug chuvirus-1" (NbuSGSBV-1). The complete genome sequence of NbuSGSBV-1 consisted of 11,375 nucleotides, which was confirmed to be a circular form by ‘around-the-genome’ reverse transcription polymerase chain reaction (RT-PCR) and sanger sequencing. Furthermore, three open reading frames (ORFs) were predicted in the NbuSGSBV-1 genome, including a large polymerase protein (L protein), a glycoprotein (G protein) and a nucleocapsid protein (N protein). Thereafter, a phylogenetic tree was constructed based on the RNA-dependent RNA polymerase amino acid sequences of all the currently available viruses in the family Chuviridae. As a result, NbuSGSBV-1 was clustered together with Sanya chuvirus 2 and Hubei odonate virus 11, indicating that NbuSGSBV-1 might belong to the genus Odonatavirus. Meanwhile, motif prediction results revealed five conserved sites among the L proteins of NbuSGSBV-1 and its homologous chiviruses. Moreover, the high abundance and typical characteristics of the NbuSGSBV-1-derived small interfering RNAs suggested the active replication of NbuSGSBV-1 in the host insect. To the best of our knowledge, this is the first report of a chuvirus identified from the insect family Pentatomidae. The discovery and characterization of NbuSGSBV-1 will help to understand the diversity of chuviruses in insects.
The response of sugar beet rhizosphere micro-ecological environment to continuous cropping
Authors: Cui Rufei , Geng Gui , Wang Gang , Stevanato Piergiorgio , Dong Yinzhuang , Li Tai , Yu Lihua , Wang Yuguang 
Published: May 2022

Abstract
Background and aims Continuous cropping can lead to increased soil-borne diseases of sugar beet and cause economic losses. We aimed to study the relationship of continuous cropping to the microbial community of each root compartment of sugar beet (Beta vulgaris L.). Methods The structure and difference of microbiome community in bulk soil (Sc and Sn), rhizosphere soil (Rc and Rn), and endosphere (Bc and Bn) of sugar beet were analyzed by high-throughput sequencing technique. Results The endophytic microbial alpha diversity of the root system was significantly lower in the continuous crop group than in the non-continuous crop group. The relative abundance of Proteobacteria increased and the relative abundance of Actinomycetes decreased in continuous cropping compared to non-continuous cropping. The relative abundance of Tausonia and Fusarium in each group of continuous cropping is greater than the non-continuous cropping. Microbial communities in all three root compartments were correlated with environmental factors, except for the rhizosphere bacterial community. Root compartments in continuous cropping are dominated by pathogenic fungi. The structural characteristics of the fungal zone show a continuous and progressive change from the bulk soil to the rhizosphere soil and then to the endosphere of sugar beet.Conclusions The accumulation or subtraction of some microbial populations during continuous sugar beet cultivation to form a specific flora has proven to be an important strategy for building the micro-ecological community structure of sugar beet. This provides a scientific reference for understanding the formation of continuous cropping obstacles in sugar beet.