bluuebunny/crossref_metadata_2025_split huggingface dataset:
Synthesis and Biological Evaluation, Structural Elucidation, Thermogravimetric
Analysis, X-Ray Diffraction Studies of a Schiff Base Derived from
3-formylchromone and 3-aminoquinoline and their Cu(II) and Co(II) Complexes
Authors: Ghumbre Sushil K. , Patil Amol V. , Renge Atul S. , Dake Satish A. , Khade Bhimrao C. 
Published: April 2022

Introduction:
The study of novel Schiff bases and their metal complexes has
achieved enormous attention of inorganic as well as medicinal chemists.

Objective:
The objective of this study is to study the structural elucidation and antimicrobial
screening of 3-formylchromone and 3-aminoquinoline-based Schiff base and their metal complexes.

Methods:
Cu(II) and Co(II) complexes of 3-((quinolino-3-ylimino) methyl)-4H-chromen-4-
one ligand were synthesized and characterized by elemental analysis, molar conductivity
measurement, infrared, UV-Visible, 1H NMR spectral studies, thermogravimetric analysis,
and powder X-ray diffraction studies.

Results:
Antibacterial activity of synthesized compounds were screened against Klebsiella
pneumoniae, Staphylococcus aureus, and Proteus vulgaris, and antifungal activity was
screened against fungi Candida albicans and Aspergillus niger. Schiff base ligand and their
Cu(II) and Co(II) complexes revealed significant antibacterial and antifungal activity against
tested strains. Octahedral geometry of metal complexes was proven by analytical, physical,
and spectral data.

Conclusion:
In this present work, novel Schiff base 3-((quinolino-3-ylimino) methyl)-4Hchromen-
4-one and its Cu(II) and Co(II) complexes revealed promising antibacterial and antifungal
activities.
Biogenic ZnO Nanoflowers: As an Alternative Antibacterial Nanomedicine
Authors: Tripathi Ravi Mani , Pudake Ramesh Namdeo , Shrivastav Braj Raj , Shrivastav Archana 
Published: April 2022

Background:
Zinc oxide (ZnO) nanoparticles have been widely investigated for the development of next-generation nano-antibiotics against a broad range of microorganisms including multi-drug resistance. The morphology of nanomaterials plays an important role in antibacterial activity.

Objective:
The research goal is focused on the development of a low-cost antibacterial agent.

Method:
The biosynthesis method was used to make ZnO nanoflowers. The antibacterial activity of these biogenic ZnO nanoflowers was analyzed by three methods: growth curve, well diffusion, and colony-forming unit count (CFU) assays.

Results:
The assay methods used in this study confirmed the antibacterial activity of ZnO nanoflowers. The growth curve shows that 0.5 mg/mL concentration of ZnO nanoflowers acted as an effective bactericide as no significant optical absorption and virtually bacterial growth were ob-served. The inhibition zone was found at 25 mm at 70 μg of ZnO nanoflowers.

Conclusion:
The unique, simplistic, environmental-friendly, and cost-effective biosynthesis method was established for the ZnO nanoflowers using biomass of Bacillus licheniformis. The resulted ZnO nanoflowers show excellent antibacterial activity which could be used as an alternative to antibiot-ics in therapeutic processes.
COVID-19 Stress on Mental and Hair Health: A Marker for Diseases in
the Post-Pandemic Era
Authors: Accorsi Daniela Xavier , dos Santos Ingrid Aparecida Mendes , Accorsi Juliana Xavier , Abelan Ursulandréa Sanches , Júnior Celso Martin , Bohac Silvia , Bumiller-Bini Valéria , Boldt Angelica Beate Winter , Chin Chung Man 
Published: April 2022

Abstract:
The seriousness of the COVID-19 pandemic with accumulating stress factors, including lack of
pharmacotherapy, quarantine, social distancing, delay of vaccination, and economic uncertainties, may
foster fear and psychiatric disorders that can precipitate or aggravate hair/scalp disease. Hair loss can lead
to decreased self-esteem, potentiating the negative effects on social life and generating a vicious cycle of
stress during the pandemic. The relationship between environment and behavior can also trigger epigenetic
changes in diseases, which may influence the health of the next generations. In this review, we describe
the interaction between the physiological mechanisms of stress on hair follicles and hair disorders and
openly discuss during pandemic/post-pandemic (not genetically determined but epigenetically triggered)
hair loss as a point of concern as a health marker for further development of chronic diseases, such as
diabetes, obesity, psychiatric disorders, and others.
Improving Web-Based Treatment Intake for Multiple Mental and Substance Use Disorders by Text Mining and Machine Learning: Algorithm Development and Validation
Authors: Wiegersma Sytske , Hidajat Maurice , Schrieken Bart , Veldkamp Bernard , Olff Miranda 
Published: April 2022

Background
Text mining and machine learning are increasingly used in mental health care practice and research, potentially saving time and effort in the diagnosis and monitoring of patients. Previous studies showed that mental disorders can be detected based on text, but they focused on screening for a single predefined disorder instead of multiple disorders simultaneously.

Objective
The aim of this study is to develop a Dutch multi-class text-classification model to screen for a range of mental disorders to refer new patients to the most suitable treatment.

Methods
On the basis of textual responses of patients (N=5863) to a questionnaire currently used for intake and referral, a 7-class classifier was developed to distinguish among anxiety, panic, posttraumatic stress, mood, eating, substance use, and somatic symptom disorders. A linear support vector machine was fitted using nested cross-validation grid search.

Results
The highest classification rate was found for eating disorders (82%). The scores for panic (55%), posttraumatic stress (52%), mood (50%), somatic symptom (50%), anxiety (35%), and substance use disorders (33%) were lower, likely because of overlapping symptoms. The overall classification accuracy (49%) was reasonable for a 7-class classifier.

Conclusions
A classification model was developed that could screen text for multiple mental health disorders. The screener resulted in an additional outcome score that may serve as input for a formal diagnostic interview and referral. This may lead to a more efficient and standardized intake process.
Machine Learning Decision Support for Detecting Lipohypertrophy With Bedside Ultrasound: Proof-of-Concept Study
Authors: Bandari Ela , Beuzen Tomas , Habashy Lara , Raza Javairia , Yang Xudong , Kapeluto Jordanna , Meneilly Graydon , Madden Kenneth 
Published: April 2022

Background
The most common dermatological complication of insulin therapy is lipohypertrophy.

Objective
As a proof of concept, we built and tested an automated model using a convolutional neural network (CNN) to detect the presence of lipohypertrophy in ultrasound images.

Methods
Ultrasound images were obtained in a blinded fashion using a portable GE LOGIQ e machine with an L8-18I-D probe (5-18 MHz; GE Healthcare). The data were split into train, validation, and test splits of 70%, 15%, and 15%, respectively. Given the small size of the data set, image augmentation techniques were used to expand the size of the training set and improve the model’s generalizability. To compare the performance of the different architectures, the team considered the accuracy and recall of the models when tested on our test set.

Results
The DenseNet CNN architecture was found to have the highest accuracy (76%) and recall (76%) in detecting lipohypertrophy in ultrasound images compared to other CNN architectures. Additional work showed that the YOLOv5m object detection model could be used to help detect the approximate location of lipohypertrophy in ultrasound images identified as containing lipohypertrophy by the DenseNet CNN.

Conclusions
We were able to demonstrate the ability of machine learning approaches to automate the process of detecting and locating lipohypertrophy.
Efecto de la nisina en la inhibición del crecimiento de Staphylococcus areus y en las propiedades sensoriales del queso costeño
Authors: Alvarez Badel Beatriz , Doria Espitia María Alejandra , Hodeg Peña Vanesa , Simanca Sotelo Mónica María , Pastrana Puche Yenis , De Paula Claudia Denise 
Published: April 2022

Se evaluó el efecto de la adición de nisina en queso costeño obtenido en la ciudad de Montería – Córdoba, Colombia, sobre la inhibición del crecimiento de Staphylococcus aureus y sobre las características sensoriales del queso. Se obtuvieron muestras de queso costeño en 9 comercializadoras de la ciudad y se aisló S. aureus, se determinó la concentración mínima inhibitoria (CMI) con nisina; se elaboró queso costeño con la adición de nisina a 0, 500 y 625 UI/kg. Se realizó el recuento de S. aureus, a las 0 y 24 h de almacenamiento; se estableció un diseño completamente al azar con 57 unidades experimentales. Se realizó una prueba triangular con panel de 40 catadores para determinar diferencias sensoriales entre el queso costeño tradicional y con adición de nisina. Se determinó que el queso costeño presentó contaminación por S. aureus; dichas cepas fueron inhibidas con una CMI de nisina de 500 UI/ml. Los recuentos de S. aureus en queso costeño adicionado con nisina presentaron diferencias significativas (P≤0.05) con el testigo; se observó que después de 24 h la nisina redujo de 2.3 ciclos logarítmicos para concentración de 500 UI/kg y 1.9 ciclos logarítmicos para 625 UI/kg. El queso costeño adicionado con 500 UI de nisina/kg no presentó diferencias (P≥0.05) en las propiedades sensoriales con relación al testigo. Se concluye que la nisina a 500 UI/ml inhibe al S. aureus aislado del queso costeño comercializado en la ciudad de Montería- Córdoba.
Family Medicine Resident and Faculty Perceptions About the Strengths and Limitations of Telemedicine Training
Authors: Venditti Sarah A. , Sazegar Payam , Fuchs Lance C. , Snarskis Carolyn E. 
Published: April 2022

Background and Objectives: Telemedicine has become a highly-utilized form of primary care, requiring medical schools and residency programs to develop standardized telemedicine training to meet learners’ educational needs. This study highlights specific areas of clinical teaching and faculty development regarded as highly valuable in a family medicine (FM) residency program.
Methods: We developed a needs assessment survey instrument based on Accreditation Council for Graduate Medical Education (ACGME) milestones and circulated it to faculty and residents at a suburban FM residency program in August 2020. We mapped each survey question to ACGME core competencies to identify common themes. We performed two-sample t tests to compare perceived self-confidence in faculty assessment and resident performance of key telemedicine clinical skills.
Results: A total of 29 respondents (15 faculty, 14 residents) completed the survey. Both residents and faculty expressed comfort with obtaining a focused history, ruling out red flag symptoms, formulating a differential diagnosis, and planning follow-up care. Faculty reported confidence in their ability to provide feedback about medical knowledge and clinical decision making, but also identified a need for better feedback tools. Both faculty and residents identified a need for better teaching of physical exam skills during video visits. There were no statistically significant differences for perceived self-confidence in evaluating and performing key telemedicine skills between faculty and residents, respectively.
Conclusion: Development of effective telemedicine educational experiences should emphasize teaching virtual communication and physical exam skills, and developing new approaches to learner evaluation.
Edição 20 (1) janeiro/março 2022
Authors: Chizzotti Antonio , Almeida Maria Elizabeth Bianconcini de 
Published: April 2022

Esta edição é lançada quando o mundo assiste ao massacre da guerra entre Rússia e Ucrânia, revelador da afronta à diversidade cultural, irrefreável em seu ímpeto patrimonialista de anexar territórios, desrespeitar a democracia, a liberdade e a ética, em uma tentativa insana de obstruir o movimento de fronteiras cada vez mais permeáveis e líquidas, que clamam por uma educação acolhedora das diversidades, convivência com as diferenças étnicas e culturais. Por armadilha do destino, esta edição presenteia os leitores com um dossiê temático denominado “Currículo, Diversidade e Diferenças Culturais”, que se posiciona em contradição aos argumentos deflagradores da guerra e testemunha a relevância de uma educação solidária, multicultural, que respeita e convive com a diversidade, que foi concebido e organizado cuidadosamente por Alípio Casali (Pontifícia Universidade Católica de São Paulo – PUC-SP, Brasil), Hildizina Norberto Dias (Universidade Pedagógica de Maputo – UPM, Moçambique) e Suely Dulce de Castilho (Universidade Federal do Mato Grosso – UFMT, Brasil). À vista disso, esta edição contempla a diversidade em suas distintas interfaces (internacional, regional, institucional, educacional e temática), tanto nos quatorze artigos do dossiê temático “Currículo, Diversidade e Diferenças Culturais”, apresentados junto ao dossiê, quanto nos seis trabalhos da demanda espontânea, referidos a seguir.
Dossiê Temático CURRÍCULO, DIVERSIDADE E DIFERENÇAS CULTURAIS
Authors: Casali Alípio , Dias Hildizina Norberto , Castilho Suely Dulce de 
Published: April 2022

Ideais iluministas de civilização e progresso seguem sustentando discursivamente o projeto de uma ‘civilização global’, dissimulando seu ímpeto originário de dominação monocultural. Não bastaram as resistências que os colonizadores europeus enfrentaram nas Américas, Ásia e África, desde o século XVI, e das quais saíram politicamente perdedores. Ademais, a Antropologia, desde o final do século XIX, ao mergulhar na diversidade de culturas (especialmente as de povos mais ancestrais) e revelar sua complexidade, corroborou as razões pelas quais tal projeto monocultural eurocêntrico deveria ter sido declarado violento e ilusório desde o início. Não obstante, ignorando lições da História, a intensificação da globalização, no pós-Guerra (1945), entendeu ser possível avançar o capitalismo contemporâneo mediante imposição de padrões via mercado. Mais uma vez, contradições e ambivalências se revelaram e, ao encarar as diferenças e buscar anular suas forças, o capitalismo globalizado logrou apenas diminuí-las parcialmente; em acréscimo, produziu todos os efeitos contrários, de revelação mais acentuada das mesmas diferenças e de potencialização de suas identidades, cujo vigor em pouco tempo se manifestou em protagonismos vários, no campo cultural. Não obstante seu relativo fracasso nessa iniciativa, o capitalismo contemporâneo assimilou essa imposição da diversidade, tratando inclusive de explorar suas potencialidades mercadológicas, e o resultado disso é que o tema da diversidade cultural tornou-se até mesmo discurso global das elites empenhadas na cooperação internacional e na governança global que lhes interessa. A dramaticidade desse tema certamente ajuda a explicar o notável afluxo de submissões de artigos de qualidade à publicação neste dossiê. Por essa razão, como organizadores, adotamos como parâmetro final de seleção dos quatorze artigos aqui publicados aquele único critério compatível com o próprio projeto do dossiê: o da diversidade (internacional, regional, institucional e temática). Buscamos a diversidade para falar da diversidade. Os leitores perceberão a ampla gama de contribuições ao Currículo possíveis de aflorar a partir de cada um e todos os artigos aqui publicados.
Factors associated with late HIV diagnosis
Authors: Khasanova G. R. , Agliullina S. T. , Gilmutdinova G. R. , Nagimova F. I. 
Published: April 2022

Aim. To assess the frequency of late HIV diagnosis among newly diagnosed HIV cases in 2019 and to determine associated risk factors.Materials and Methods. The study included data from 1073 adult patients who lived in the Tatarstan Republic and were first diagnosed with HIV infection in 2019. Criteria for late HIV diagnosis were the presence of stage 4 HIV-infection (AIDS) and/or < 200 CD4+ cells per mm3 at the time of diagnosis. The influence of various factors on the timeliness of diagnosis was carried out using binary logistic regression and adjusted odds ratios (aOR) with 95% confidence intervals (95% CI).Results. Late diagnosis was documented in 37.7% of HIV infection cases. Clinical examination was associated with late diagnosis in comparison with a preventive examination (aOR = 2.06; 95% CI = 1.40–3.02). The age of ≥ 50 years was associated with late diagnosis in comparison with 30−49 years age range (aOR = 2.18; 95% CI = 1.41–3.37). Vice versa, the age of < 30 years was associated with timely diagnosis as compared to 30−49 years age range (aOR 0.44; 95% CI = 0.30–0.68). Living in urban areas has been associated with late HIV diagnosis (aOR = 1.470; 95% CI = 1.002–2.153) in comparison with living in rural areas.Conclusion. The factors associated with the late HIV diagnosis were examination for clinical indications, age ≥ 50 years, and living in urban areas. For curbing the HIV epidemic, it is necessary to expand the HIV screening to all population groups, especially elderly.
Inflammatory markers and organ dysfunction in patients with severe influenza A (H1N1) virus-associated pneumonia
Authors: Malyarchikov А. V. , Shapovalov K. G. , Morozova E. I. , Lukyanov S. A. , Kazantseva L. S. 
Published: April 2022

Aim. To assess inflammatory markers and organ dysfunction in patients with severe influenza A (H1N1) virus-associated pneumonia.Materials and Methods. The study included 50 patients (median age 47 (38-62) years, 24 males and 26 females) with severe influenza A (H1N1) virus-associated pneumonia. We analysed the clinicopathological data as well as complete blood count and biochemical profile. Organ dysfunction was assessed using SOFA and qSOFA scales.Results. The prevalence of multiple organ dysfunction syndrome in patients with severe influenza A (H1N1) virus-associated pneumonia was 46% (23/50 patients). Patients frequently suffered from insufficient oxygenation, impaired coagulation, altered haemodynamics, and central nervous system dysfunction. Out of 23 patients with multiple organ dysfunction syndrome, 10 (43.5%) suffered from reduced oxygenation and excessive coagulation, while 6 (26.0%) had all mentioned syndromes combined. Thrombocytopenia was detected as early as at day 1-2 of the disease and was further accompanied by an increase in the erythrocyte sedimentation rate and white blood cell count from day 2 to day 8. An increase in acute-phase proteins (C-reactive protein and fibrinogen) was noted at the day 5-6 of the disease.Conclusion. In patients with severe influenza A (H1N1) virus-associated pneumonia, an early systemic inflammatory response evolves into an uncontrolled multiple organ dysfunction syndrome by day 7-8 of infection.
Patterns and Prevalence of Self-Medication Practices among Medical Students in Oman
Authors: Asaad Alhasan , Al Mahruqi Isra , Al Kharousi Kawthar , Malik Saniha 
Published: April 2022

Background: Self-medication which is the selection and self-administration of medicines to manage or treat symptoms, has become a quite common practice that is on the rise.
Objectives: exploring the prevalence of self-medication practices among medical students, and its different patterns across the batches of the medicine program, and identifying and assessing the different reasons behind self-medication practices among medical students.
Methods: A cross sectional study directed at medical students at the National University of Sciences and Technology in Sohar and Rustaq’s campuses, in Oman. It included students from the second, third, fourth, fifth, sixth and seventh years. 212 responses were obtained in total. Data was collected through confidential anonymous questionnaires after obtaining consents.
Results: Of the 212 responses, 88.7% were females, while only 11.3% were males, their ages ranging from 17 to above 26. The prevalence of self-medication was 63.2%, most of those who self-medicated were younger, female students, with over-the-counter drugs due to previous experiences and mildness of the symptoms. The most common ailments that prompted the students to self-medicate included headaches, cold and fever.
Conclusion: the prevalence of self-medication amongst medical students in the National University of Sciences and Technology in Oman, is quite high. This calls for an early intervention and raising awareness on the topic.
Protein-Protein Interaction Network and Novel Biomarkers of Celiac Disease
Authors: Chowdhury Selia , Bappy Mehedi Hasan , Chowdhury Md. Shahraj , Chowdhury Nurjahan Shipa , Patousis Athanasios , Gerothanasi Anna , Patousis Panagiotis , Chowdhury Samia , Chowdhury Shajeda 
Published: April 2022

Background: Celiac disease is a small intestine enteropathy. Gluten exposure in the diet of those who are vulnerable causes it. Susceptibility is determined by genetics. Despite advancements in technology, small intestinal biopsy remains the gold standard for diagnosing Celiac disease.
Methods: Differentially expressed proteins related to celiac disease were collected from published research articles and considered for this study. Gene IDs of all proteins contained in the data set were identified using the NCBI Gene Database. The list of entrez gene IDs was then entered into the bio profiling software to look for protein-protein interactions between the gene IDs.
Results: Using the Protein-Protein Interaction (PPI) spider model, numerous important signaling pathways implicated in the proteome of Celiac disease have been discovered. The p values of model D1 and D2 were <0.03 and <0.05, respectively. Model D1 depicts the pathway involved, which includes reverse cholesterol transport and model D2 depicts the pathway involved, which include anti-apoptosis, response to virus, and positive regulation of I-kappaB kinase/NF-kappaB cascade.
Conclusions: The deregulation of several pathways and protein interaction networks is suggested by bioinformatic analysis of the differentially expressed proteins. Following validation, the unique biomarkers discovered can be utilized to better understand this illness and identify potential pharmaceutical therapies.
Spousal Selection for Marriage by Tertiary Students in Wa Municipality of Ghana: Internal Factors in Perspective
Authors: Amuasi Gideon K. , Alhassan Eliasu 
Published: April 2022

In contemporary society marriage is seen as the foundation of all social relations and it has remained an important goal for youngsters to achieve in the future. Spouse selection over the years especially, among adults had received extensive attention in the academic tertiary institutions in Ghana, yet little is known precisely about the internal determining factors influencing spouse selection for marriage especially among tertiary students. This current study seek to unearth the internal factors that informs individual choice for marriage among students in the public universities in Ghana. Stimulus-Value-Role (SVR) theory anchored the study and also a simultaneous mixed design was used for the study. The public Universities were sampled Ninety-three respondents were interviewed. Both primary and secondary data were sourced and descriptive statistics was used for the analyses. The findings showed that more than 93% of the students (both sexes) consider issues such as intelligence, emotional stability, dependable attitude, maturity and religion of their prospective spouses as important in the selection process. Agreeableness which is one of the extraversion dimensions and talks about how friendly and compassionate a person is was identified as the most effective element considered in the selection process. The study concluded that students varied in the exact factors they anticipated, desiring potential mates with compatibility factors truly want to find spouses who exemplified what they preferred. The study recommended that the counsellors of the tertiary institutions should endeavour to organize marriage seminars for students to educate them on the need to be cautious of the desired factors. The desired factors predict significantly on students’ choices of a spouse for marriage.