bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association of Householder Smoking With Poverty and the Mediating Effect of NCDs in Relatively Underdeveloped Regions in China
Authors: Yang Huimin , Chen Bowen , Guo Aili , Song Jiarui , Cheng Xi , Jin Chenggang 
Published: May 2022

Background:Studies have not provided clear enough evidence on the direct association between cigarette smoking and poverty. This study aims to assess the association of householder smoking with near-poverty households, and the potential mediating effect of NCDs.MethodsA cross-sectional survey was conducted from November 2019 to October 2020 in relatively underdeveloped regions in China. In total, 2,409 households were investigated in areas under the jurisdiction of 24 primary health care (PHC) institutions of eight provinces. Pearson's χ2-test was performed, and multivariable logistic regression and extended probit regression models were fitted to examine the association between householder smoking and near-poverty households. Moreover, generalized structural equation modeling was used to explore the mediating effect of NCDs.ResultsAfter adjusting for all other potential confounding factors, compared with households headed by never-smokers, households headed by smokers exhibited significantly elevated risks of being near poverty, with an odds ratio of 2.01 (95% CI: 0.48–0.91). We also found that living in rural areas and having a low education level both had a negative effect on being near poverty. Additionally, NCDs had a significantly positive mediating effect, with a 31.57% effect of householder smoking on near-poverty status mediated by NCDs; the indirect effect was estimated to be 0.17 (95% CI: 0.04–0.31).ConclusionsHouseholder smoking significantly elevated the risk of the household being near poverty, and suffering NCDs had a positive mediating effect.
Systematic Bibliometric Analysis of Research Hotspots and Trends on the Application of Virtual Reality in Nursing
Authors: Zhao Junqiang , Lu Yi , Zhou Fujun , Mao Ruping , Fei Fangqin 
Published: May 2022

BackgroundWith the emergence of the metaverse, virtual reality, as a digital technology, must be getting hotter. High quality virtual reality related nursing knowledge scene learning is gradually replacing traditional education and intervention skills.ObjectiveThis systematic study aimed to gain insights into the overall application of virtual reality technology in the study of nursing.MethodsCitations downloaded from the Web of Science Core Collection database for use in VR in nursing publications published from January 1, 2012, to December 31, 2021, were considered in the research. Information retrieval was analyzed using https://bibliometric.com/app, CiteSpace.5.8. R3, and VOS viewer.ResultsA total of 408 institutions from 95 areas contributed to relevant publications, of which the United States is the most influential country in this research field. The clustering labels of cited documents were obtained from the citing documents. Virtual simulation, virtual learning, clinical skills, and dementia are the clustering labels of co-cited documents. The burst keywords represented the research frontiers in 2020–2021, which were knowledge and simulation.ConclusionVirtual nursing has had an impact on both nurses and clients. With the emergence of the concept of the metaverse, the research and application of virtual reality technology in nursing will gradually increase.
Effect of High-Quality Whole-Course Care on Psychological Status and Postoperative Pharyngeal Complications in Patients Undergoing Surgery for Hyperparathyroidism Secondary to Chronic Rrenal Failure
Authors: Luo Qinghong , Zheng Shuquan 
Published: May 2022

ObjectiveTo observe the effects of high-quality whole-course care on the psychological status and postoperative pharyngeal complications in patients undergoing surgery for secondary hyperparathyroidism (SHPT) to chronic rrenal failure (CRF).MethodsThe clinical data of 62 patients who underwent surgical treatment for CRF-SHPT from April 2018 to October 2021 in our department were retrospectively analyzed. According to the different nursing methods after admission, they were divided into two groups, of which 33 patients who received high-quality whole-course care were the high-quality group, and 29 patients who received routine nursing were the regular group. Compliance, occurrence of pharyngeal complications, improvement of preoperative and postoperative psychological status [Assessed by self-rating anxiety scale (SAS) and self-rating depression scale (SDS)], nursing satisfaction scores, and serum hormone levels [intact parathyroid hormone (iPTH), calcium (Ca), Phosphorus (P)] were compared between the two groups.ResultsThe differences between the general conditions and clinical characteristics of the two groups were not significant (p &gt; 0.05). After care, the number of cases with good compliance in the high-quality group was higher than that in the regular group, and the number of cases with non-compliance was lower than that in the regular group (p &lt; 0.05); the difference in the number of cases with partial compliance after care between the two groups was not significant (p &gt; 0.05). There was no significant difference in the incidence of pharyngeal complications such as sore throat, nausea and vomiting, dry throat and hoarseness between the two groups (p &gt; 0.05); however, the 24-h postoperative sore throat and dry throat scores in the high-quality group were significantly lower than those in the regular group (p &lt; 0.05). Patients in the high-quality group had higher nursing attitude, nursing skills, nursing safety, nursing quality, and overall nursing satisfaction scores than the regular group (p &lt; 0.05). Compared with the pre-care period, SAS and SDS scores decreased in both groups after care, and SAS and SDS scores decreased more in the high-quality group than in the regular group (p &lt; 0.05). Serum iPTH, Ca, and P levels decreased in both groups at 1 week after surgery, and iPTH, Ca, and P levels decreased more in the high-quality group than in the regular group (p &lt; 0.05).ConclusionThrough the high-quality whole-course care, full informed participation and active cooperation of CRF-SHPT patients, close medical and nursing collaboration, attention to detail and overall level of treatment can effectively improve patient compliance, psychological status and postoperative serum indicators, promote patient recovery and improve nursing satisfaction.
High Expression of TIMELESS Predicts Poor Prognosis: A Potential Therapeutic Target for Skin Cutaneous Melanoma
Authors: Zhao Shixin , Wen Shifeng , Liu Hengdeng , Zhou Ziheng , Liu Yiling , Zhong Jinbao , Xie Julin 
Published: May 2022

BackgroundSkin cutaneous melanoma (SKCM) is the most lethal skin cancer with an increasing incidence worldwide. The poor prognosis of SKCM urgently requires us to discover prognostic biomarkers for accurate therapy. As a regulator of DNA replication, TIMELESS (TIM) has been found to be highly expressed in various malignancies but rarely reported in SKCM. The objective of this study was to evaluate the relationship between TIM and SKCM tumorigenesis and prognosis.MethodsWe obtained RNA sequencing data from TCGA and GTEx to analyze TIM expression and differentially expressed genes (DEGs). Subsequently, GO/KEGG, GSEA, immune cell infiltration analysis, and protein-protein interaction (PPI) network were used to perform the functional enrichment analysis of TIM-related DEGs. Moreover, the receiver operating characteristic (ROC) curves, Cox regression analysis, Kaplan–Meier (K-M) analysis, and nomograms were applied to figure out the clinical significance of TIM in SKCM. In addition, we investigated the relationship between TIM promoter methylation and SKCM prognosis through the UALCAN database. Finally, the immunohistochemical (IHC) results of normal skin and SKCM were analyzed to determine expression differences.ResultsTIM was significantly elevated in various malignancies, including SKCM, and high expression of TIM was associated with poor prognosis. Moreover, a total of 402 DEGs were identified between the two distinct TIM expression groups, and functional annotation showed enrichment with positive regulation of cell cycle and classic oncogenic pathways in the high TIM expression phenotype, while keratinization pathways were negatively regulated and enriched. Further analysis showed that TIM was correlated with infiltration of multiple immune cells. Finally, IHC validated the differential expression of TIM in SKCM.ConclusionTIM might play a pivotal role in tumorigenesis of SKCM and is closely related to its prognosis.
EVALUATION OF KALMYK BREED THE CREATED TYPE OF ADUCHI BY THE GENES BGH, TG5, GDF5, LEP/A80V
Authors: КАЮМОВ Ф.Г. , ТРЕТЬЯКОВА Р.Ф. 
Published: May 2022

Изучена структура стада мясного типа калмыцкой породы крупного рогатого скота Адучи по генам bGH, TG5, GDF5, LEP/A80V. Опыт проводили в Республике Калмыкия. Животные находились в одинаковых условиях кормления и содержания. По локусу гена GDF5 частота встречаемости генотипов CC составила 83%, TT — 6,3%, CT — 10,7%. При исследовании стада по гену TG5 установлено наибольшее количество особей — 67 (59,8%) с генотипом СС. Оценка стада по гену bGH показала низкое распространение животных с генотипом VV — 19,7%. В целом по стаду встречаемость L-аллеля в локусе гена bGH преобладала над V-аллелем на 26,8%. Частота А-аллеля гена LEP/A80V у исследуемых животных составила 0,674, V-аллеля — 0,326. Проведенный опыт позволил оценить генетическую структуру нового высокопродуктивного мясного типа на основе взаимодействия наследственности скота калмыцкой породы и абердин ангусской американской селекции.
The aim of the study was to study the structure of the gene pool of the meat-type herd "Aduchi" of the Kalmyk breed according to the genes bGH, TG5, GDF5, LEP /A80V. The studied animals were kept in the same conditions of feeding and maintenance. The experiment with animals was conducted in LLC "Agrofirma "Aduchi" in the Republic of Kalmykia. As a result of the study of animals by the GDF5 gene locus, the frequency of occurrence of CC genotypes was 83%, TT - 6.3%, CT - 10.7%. When studying the herd by the TG5 gene, the largest number of individuals was found – 67 (59,8%) with the СС genotype. The evaluation of the herd by the bGH gene showed a low distribution of animals with the VV genotype - 19.7%. In the herd as a whole, the occurrence of L - alleles at the bGH gene locus prevailed over V–alleles by 26.8%. The frequency of the A-allele of the LEP /A80V gene in the studied animals was 0.674, the V-allele was 0.326. The conducted experiment allowed us to evaluate the genetic structure of a new highly productive, meat-type "Aduchi" based on the interaction of the heredity of Kalmyk cattle and the Aberdeen Angus breed of American breeding.
MILK PRODUCTIVITY OF RED-AND-WHITE COWS WITH DIFFERENT BETA-CASEIN GENOTYPES
Authors: КАЛАШНИКОВА Л.А. , ХАБИБРАХМАНОВА Я.А. , ГОЛУБКОВ А.И. , НАЛЬВАДАЕВ Н.Я. , БАГАЛЬ И.Е. , РЫЖОВА Н.В. , ГАНЧЕНКОВА Т.Б. , ПАВЛОВА И.Ю. 
Published: May 2022

Изучены генотипы бета-казеина и показатели молочной продуктивности коров высшей селекционной группы красно-пестрой породы в 6 племенных хозяйствах Воронежской области (n=88), Республики Мордовия (n=82), Красноярского края (n=170). Установлено, что в высшей селекционной группе коров красно-пестрой породы преобладает аллель А2 бета-казеина с частотой 0,53. Частота этого аллеля в племенных хозяйствах различается в 2,3 раза и колеблется от 0,300 до 0,696. В 2-х хозяйствах коровы с генотипом А1А1 имеют недостоверное преимущество по показателю среднего удоя за 305 дней лактации над генотипом А2А2. В 4-х хозяйствах животные с генотипом А2А2 превосходят особей с генотипом А1А1 по удою. Высокой частотой аллеля А2 бета-казеина и положительной связью генотипа А2А2 с показателями молочной продуктивности отличаются коровы племенных хозяйств Красноярского края, где в одном из них особи с генотипом А2А2 превосходят животных с генотипом А1А1 и А1А2, соответственно, на 640 кг и 1121 кг молока (Р≤0,001), в другом удой особей с генотипом А2А2 выше, чем с генотипом А1А1 на 311 кг молока (Р≤0,05), а в третьем показатели удоя коров с генотипом А2А2 превышают таковые с генотипом А1А1 на 463 кг молока (Р≤0,01).
The genotypes of beta-casein and indicators of milk productivity of cows of the highest breeding group of the redand-white breed in 6 breeding farms of the Voronezh region (n=88), the Republic of Mordovia (n=82), the Krasnoyarsk Territory (n=70) were studied. It was found that in the highest breeding group of red-and-white cows, the A2 beta-casein allele prevails with a frequency of 0.53. The frequency of this allele in breeding farms differs by 2.3 times and ranges from 0.300 to 0.696. In 2 farms, cows with the A1A1 genotype have an unreliable advantage in terms of average milk yield for 305 days of lactation over genotype A2A2. In 4 farms, animals with the A2A2 genotype outperform individuals with the A1A1 genotype in milk yield. Breeding farms of the Krasnoyarsk Territory are distinguished by the high frequency of the A2 beta-casein allele and the positive association of the A2A2 genotype with milk productivity indicators, where in one of them cows with the A2A2 genotype outperform animals with the A1A1 and A1A2 genotypes, respectively, by 640 kg and 1121 kg of milk (P≤0.001), in the other the milk yield of individuals with the genotype A2A2 is higher than with the A1A1 genotype by 311 kg of milk (P<0.05), and in the third, the milk yield of cows with the A2A2 genotype exceeds those with the A1A1 genotype by 463 kg of milk (P<0.01).
Construction of structures of reinforced polymeric composite materials in generalized and reduced parameters, properties and methods of processing into a product
Authors: SIMONOV-EMELYANOV I. D. , SHALGUNOV S. I. 
Published: May 2022

For the first time, a model and description of the monolithic structure of reinforced plastics in one direction (1D-structure) is proposed in new generalized and reduced parameters (Θ, Θ/В and Θ/Sf), which allow to consider structure formation from the side of the reinforcing fiber taking into account its dimensions, packaging, surface size and content, and on the other, a polymer matrix, representing it in the form of three functional components.RPCM are classified according to the structural principle into: non-reinforced, weakly reinforced, medium-reinforced, reinforced, highly reinforced, extremely reinforced and super-highly reinforced plastics. The critical values of the generalized and reduced parameters of the transitions of RPCM from one type of structure to another are established, according to the classification, andit is shown that the structural transition is accompanied by a change in the technological and operational properties of reinforced plastics.For the first time, generalized and reduced parameters and type of the structure of reinforced plastics were connected with pressure of moulding and method of plastics processing into products.
Gastroschisis: Initial Management according to General Practitioner Competence
Authors: Ibrahim Tri M. , Lampus Harsali , Thomas Jeiny 
Published: May 2022

Abstract: Gastroschisis is the most common congenital defect in the abdominal wall in the last 30 years. This may be related to increased incidence of prematurity and increased survival rate of premature babies. Defects in the abdominal wall usually occur less than 4 cm, located at the junction of umbilicus and normal skin.Relatively young maternal age (<21 years), as well as habits of consuming alcohol and drugs can increase the risk of gastroschisis.Diagnosis can be confirmed at prenatal stage by using USG, and at postnatal stage. Initial treatment consists of fluid resuscitation, oxygenation, decompressed nasograstic tube (NGT), and hypothermia prevention. In conclusion, gastroschisis needs immediate treatment by prevention of hypothermia in infants, administration of fluid and oxygen, and closure of defect. The overall survival rate is quite good and the prognosis depends on the condition of the gut at birth. Keywords: gastroschisis Abstrak: Gastroschisis merupakan defek kongenital pada dinding abdomen yang paling umum ditemukan dalam 30 tahun terakhir. Hal ini mungkin terkait dengan peningkatan kejadian prema-turitas dan peningkatan kelangsungan hidup bayi prematur.Defek pada dinding abdomen terjadi biasanya kurang dari 4 cm dan terletak di antara sambungan umbilikus dan kulit normal. Usia ibu yang relatif muda (<21 tahun), kebiasaan mengonsumsi alkohol serta obat-obatan dapat mening-katkan risiko terjadinya gastroschisis. Diagnosis dapat ditegakkan saat prenatal dengan USG, dan postnatal. Penatalaksanaan awal meliputi resusitasi cairan, pemberian oksigenasi, pemasangan nasogastric tube (NGT) dekompresi, serta mencegah terjadinya hipotemia. Simpulan tulisan ini ialah gastroschisis memerlukan penanganan segera dengan melakukan pencegahan terjadinya hipotermia pada bayi, pemberian cairan, pemberian oksigenasi, dan penutupan defek. Tingkat kelangsungan hidup secara keseluruhan cukup baik dan prognosis tergantung pada kondisi usus saat lahir.Kata kunci: gastroschisis
Pharmacovigilance among patients with multi drug resistance tuberculosis (MDR-TB) treatment-a prospective study
Authors: D Ashalatha , C Roopkumar , K Premraj , V Vani , P Narayana swamy , P Venkatesh 
Published: May 2022

Background: ADRs are frequent in patients of MDR-TB on DOTs-Plus drug regimen. Current study was carried out in tertiary care hospital. Recognition of types and frequency of adverse drug reactions in Intensive and continuation phase of MDR- TB Patients.
Methods: It was a prospective observational study conducted in Damien Foundation Urban Leprosy & TB Centre, Nellore. All the MDR-TB patients admitted at the directly observed treatment, short course plus (DOTS plus) Center were enrolled and were monitored for ADRs. The causality and severity of the reactions were determined using Naranjo algorithm.
Results: A total of 200 tuberculosis patients of MDR-TB on DOTS therapy were enrolled for the study. Out of 200 patients, 10 were dropouts, 10 defaulted so 190 patients assessed for ADRs, 129 patients developed 109 (56.48%) adverse drug reactions. The higher numbers of ADRs were observed in age group 31- 40yrs followed by 21-30yrs which were more common in men. Majority of adverse drug reactions were Gastrointestinal (GI) problems 48 (37.20%), followed by Ototoxicity 7 (5.42%) and Psychiatric Manifestations 3 (2.321 %) and skin problems 3 (2.32%). On evaluation of the causality of ADRs, majority were found to be Possible (57.95%). The severity assessment showed that most of the patients ADRs were of moderate level (42.04%).
Conclusions: ADRs are major factor limiting completion of drug therapy under RNTCP and occurrence of drug resistance which requires attention of all health care professionals.
Implementasi Pendidikan Karakter Cinta Tanah Air Dalam Proses Pembelajaran Di Sekolah Dasar
Authors: Daud Daud , Triadi Yanuar 
Published: May 2022

Tujuan penelitian: Penelitian ini bertujuan untuk melihat implementasi pendidikan karakter cinta tanah air di sekolah dasar Metodologi: Jenis penelitian ini adalah penelitian kualitatif Temuan utama: Pelaksanaan pendidikan karakter religius, cinta tanah air, disiplin sudah berjalan dengan baik sesuai sebagaimana yang diharapkan. Namun perlu ada beberapa perbaikan lagi, seperti RPP yang dijadikan pedoman dalam pelaksanaan pendidikan karakter ini. Penulisan RPP lebih diperbaiki lagi berfungsi sebagaimana mestinya. Karena melalui RPP bisa mewujudkan pendidikan karakter yang religius pada siswa, sesuai dengan model pembelajarannya yaitu, keteladanan, pembinaan disiplin, CTL pembiasaan bermain peran, serta pembelajaran yang partisipatif. Keterbaruan penelitian: Sikap cinta tanah air merupakan suatu sikap yang menunjukkan kepedulian, penghargaan yang didasari semangat kebangsaan yang tinggi dan rela berkorban demi masa depan bangsa. Sikap cinta tanah air juga diartikan sebagai sikap mencintai produk dalam negeri, budaya-budaya sendiri, rajin belajar demi kemajuan bangsa kedepannya, mencintai lingkungan hidup sekitar dan bermanfaat bagi masyarakat, diri sendiri dan juga keluarga, melaksanakan hidup bersih dan teratur, serta mencerminkan perilaku berkarakter dalam kehidupan sehari-hari.
Perencanaan Sarana Dan Prasarana Pendidikan Islami di Lembaga Pendidikan
Authors: Samanhudi  
Published: May 2022

Abstrak
Dalam meningkatkan kualitas pembelajaran di lembaga pendidikan terdapat beberapa factor yang menentukan, mulai dari kurikulum, materi, metode, pendidik, tenaga kependidikan, peserta didik, sarana, prasarana, dan sebagainya. Untuk meningkatkan kualitas pembelajaran dan prestasi peserta didik, diperlukan adanya perencanaan, diantaranya adalah perencanaan sarana dan prasarana pendidikan. Sarana dan prasarana merupakan salah satu factor penting dalam meningkatkan kualitas pembelajaran dan prestasi peserta didik. Sarana dan prasarana seyogyanya disesuaikan dengan kebutuhan dan sejalan dengan visi dan misi lembaga pendidikan itu sendiri. Tulisan ini menjelaskan tentang perencanaan sarana dan prasarana pendidikan Islami. Hal ini perlu dilakukan agar sarana dan prasarana yang disiapkan lembaga pendidikan sejalan dengan nilai-nilai agama Islam. Metode yang digunakan dalam penelitian ini adalah kualitatif dengan pendekatan analisis deskriptif kualitatif. Kesimpulan dari kajian ini adalah menunjukkan bahwa guna mencapai tujuan pendidikan diperlukan adanya sarana dan prasarana pendidikan, meliputi perencanaan, tujuan dan manfaat, perinsip perencanaan, prosedur, klasifikasi, pengadaan sarana dan prasarana pendidikan. Pengadaan sarana dan prasaran yang direncanakan akan menghasilkan sarana dan prasarana yang baik dan tepat guna, sehingga proses belajar mengajar akan berhasil dengan dukungan sarana dan prasarana yang memadai.
Abstract
In improving the quality of learning in educational institutions, there are several factors that determine, starting from the curriculum, materials, methods, educators, education staff, students, facilities, infrastructure, and so on. To improve the quality of learning and student achievement, planning is needed, including planning for educational facilities and infrastructure. Facilities and infrastructure are one of the important factors in improving the quality of learning and student achievement. Facilities and infrastructure should be tailored to the needs and in line with the vision and mission of the educational institution itself. This paper describes the planning of Islamic education facilities and infrastructure. This needs to be done so that the facilities and infrastructure prepared by educational institutions are in line with Islamic religious values. The method used in this research is qualitative with a qualitative descriptive analysis approach. The conclusion of this study is to show that in order to achieve educational goals it is necessary to have educational facilities and infrastructure, including planning, objectives and benefits, planning principles, procedures, classification, procurement of educational facilities and infrastructure. Procurement of planned facilities and infrastructure will produce good and effective facilities and infrastructure, so that the teaching and learning process will be successful with the support of adequate facilities and infrastructure.
La herencia de Prometeo. Las enfermedades ocupacionales en el Corpus Hippocraticum
Authors: Sierra Martín César 
Published: May 2022

El presente trabajo analiza las enfermedades ocupacionales en el Corpus Hippocraticum. Principalmente nos centraremos en Epidemias, que recoge numerosas historias clínicas, con el objetivo de analizar la asistencia sanitaria de los trabajadores en la médica griega. Finalmente, abordamos el debate historiográfico en torno al acceso a la sanidad en el mundo antiguo.