bluuebunny/crossref_metadata_2025_split huggingface dataset:
Isotopic signature in isolated south-western populations of European brown bear (Ursus arctos)
Authors: García-Vázquez Ana , Crampton Denise A. , Lamb Angela L. , Wolff George A. , Kiriakoulakis Kostas , Guidarelli Giulia , Loy Anna , Ciucci Paolo , Groff Claudio , Pinto-Llona Ana C. , Grandal-d’Anglade Aurora , Meloro Carlo 
Published: October 2022

AbstractStable isotope analysis of animal tissue samples is increasingly used to study the trophic ecology of target species. The isotopic signatures respond to the type of diet, but also to the environmental conditions of their habitat. In the case of omnivorous, seasonal or opportunistic feeding species, the interpretation of isotopic values is more complex, as it is largely determined by food selection, either due to individual choice or because of availability. We analysed C and N isotopes in brown bear (Ursus arctos) hair from four isolated populations of south-western Europe (Cantabrian, Pyrenees, Central Apennines and Alpine) accounting for the geographical and climatic differences among the four areas. We found inter-population differences in isotopic signatures that cannot be attributed to climatic differences alone, indicating that at least some bears from relatively higher altitude populations experiencing higher precipitation (Pyrenees) show a greater consumption of animal foods than those from lower altitudes (Cantabrian and Apennines). The quantification of isotopic niche space using Layman’s metrics identified significant similarities between the Cantabrian and Central Apennine samples that markedly differ from the Pyrenean and Alpine. Our study provides a baseline to allow further comparisons in isotopic niche spaces in a broad ranged omnivorous mammal, whose European distribution requires further conservation attention especially for southern isolated populations.
Comparative analysis of charter party clauses versus marine insurance contractual terms: present legal status and future trends
Authors: Boviatsis M. 
Published: October 2022

AbstractThis paper aims to classify and assess the impact of charter party clauses against the contractual terms of marine insurance contracts. Initially, a contractual term may be classified as a condition, a warranty, or an innominate term when the nature of a clause is not yet classified. Based on this classification, the effectiveness of those terms and the available remedies vary significantly upon a contractual dispute or termination. Specifically, the classification of a term as a condition has similar effects in charter parties and insurance contracts, namely, the termination of the contract and/or claim for damages. Nevertheless, the marine insurance conditions also rely on the claim’s seriousness to effectively provide the election of contractual termination, thus rendering them rather weakened compared to charter parties. At the same time, classifying a term as a warranty always had a different impact. The classification of a term as a warranty in a charter party may only offer as a remedy compensation for damages, but not the option to terminate the contract. In insurance contracts, the classification of a term as a warranty provides the same options to the affected party as a term classified as a condition, namely, the termination of the contract and/or claim for damages. With the introduction of MIA 2015, the affected party, when triggering a warranty, has a third option, namely, to be able to amend the contractual relationship in case reasons of termination emerge, protecting at the same time the other party, rendering it irresponsible of any damages or claims until the contractual relationship is reinstated.
The ubiquitin ligase RNF2 stabilizes ERα and modulates breast cancer progression
Authors: Yuan Lei , Li Xin , Yang Huijie , Li Huixiang 
Published: October 2022

AbstractEstrogen receptor α (ERα) is the most common clinical marker used for breast cancer prognosis and the classification of breast cancer subtypes. Clinically, patients with estrogen receptor-positive breast cancer can receive endocrine therapy. However, resistance to endocrine therapy has become an urgent clinical problem. A large number of previous studies have proven that posttranslational modification of the estrogen receptor is significantly related to endocrine therapy resistance. RNF2 is a member of the RING finger protein family that functions as an E3 ubiquitin ligase. Several studies have clarified that RNF2 is a critical regulator of ERα transcriptional regulation. In our current study, we identified RNF2 as an important posttranslational modification regulator of the estrogen receptor. RNF2 depletion inhibited breast cancer cell progression and ERα signaling activity. TCGA data analysis indicated that RNF2 was elevated in breast malignancies, while RNF2 depletion could drastically inhibit estrogen response gene expression on a whole-genome scale. TCGA data analysis revealed that RNF2 was positively correlated with ERα target gene expression. Further mechanistic studies showed that RNF2 was mainly localized in the nucleus and associated with ERα. The association increased ERα stability by inhibiting ERα K48-linked polyubiquitination. In conclusion, our study implicates nongenomic regulation by RNF2 on ERα protein stability and suggests that targeting RNF2 could be a promising strategy for breast cancer treatments.
Heat Health Risk and Adaptability Assessments at the Subdistrict Scale in Metropolitan Beijing
Authors: Su Xiaokang , Wang Fang , Zhou Demin , Zhang Hongwen 
Published: October 2022

AbstractAgainst the background of global climate change, the increasing heat health risk from the combined effect of changes in high temperature, exposure, vulnerability, and other factors has become a growing concern. Yet the low number of temperature observation stations is insufficient to represent the complex changes in urban heatwaves, and subdistrict-scale (town, township, neighborhood committee, and equivalent) heat health risk and adaptability assessments are still limited. In this study, we built daytime and nighttime high-temperature interpolation models supported by data from 225 meteorological stations in Beijing. The models performed well at interpolating the cumulative hours of high temperature and the interpolation quality at night was better than that during the day. We further established a methodological framework for heat health risk and adaptability assessments based on heat hazard, population exposure, social vulnerability, and adaptability at the subdistrict scale in Beijing. Our results show that the heat health risk hotspots were mainly located in the central urban area, with 81 hotspots during the day and 76 at night. The average value of the heat health risk index of urban areas was 5.60 times higher than that of suburban areas in the daytime, and 6.70 times higher than that of suburban areas in the night. Greater population density and higher intensity of heat hazards were the main reasons for the high risk in most heat health risk hotspots. Combined with a heat-adaptive-capacity evaluation for hotspot areas, this study suggests that 11 high-risk and low-adaptation subdistricts are priority areas for government action to reduce heat health risk in policy formulation and urban development.
Recent Progress on Flexible Room-Temperature Gas Sensors Based on Metal Oxide Semiconductor
Authors: Ou Lang-Xi , Liu Meng-Yang , Zhu Li-Yuan , Zhang David Wei , Lu Hong-Liang 
Published: October 2022

AbstractWith the rapid development of the Internet of Things, there is a great demand for portable gas sensors. Metal oxide semiconductors (MOS) are one of the most traditional and well-studied gas sensing materials and have been widely used to prepare various commercial gas sensors. However, it is limited by high operating temperature. The current research works are directed towards fabricating high-performance flexible room-temperature (FRT) gas sensors, which are effective in simplifying the structure of MOS-based sensors, reducing power consumption, and expanding the application of portable devices. This article presents the recent research progress of MOS-based FRT gas sensors in terms of sensing mechanism, performance, flexibility characteristics, and applications. This review comprehensively summarizes and discusses five types of MOS-based FRT gas sensors, including pristine MOS, noble metal nanoparticles modified MOS, organic polymers modified MOS, carbon-based materials (carbon nanotubes and graphene derivatives) modified MOS, and two-dimensional transition metal dichalcogenides materials modified MOS. The effect of light-illuminated to improve gas sensing performance is further discussed. Furthermore, the applications and future perspectives of FRT gas sensors are also discussed.
Evaluation of Transmission Losses of Various Battery Electric Vehicles
Authors: Hengst Johannes , Werra Matthias , Küçükay Ferit 
Published: October 2022

AbstractTransmission losses in battery electric vehicles have compared to internal combustion engine powertrains a larger share in the total energy consumption and play therefore a major role. Furthermore, the power flows not only during propulsion through the transmissions, but also during recuperation, whereby efficiency improvements have a double effect. The investigation of transmission losses of electric vehicles thus plays a major role. In this paper, three simulation models of the Institute of Automotive Engineering (the lossmap-based simulation model, the modular simulation model, and the 3D simulation model) are presented. The lossmap-based simulation model calculates transmission losses for electric and hybrid transmissions, where three spur gear transmission concepts for battery electric vehicles are investigated. The transmission concepts include a single-speed transmission as a reference and two two-speed transmissions. Then, the transmission lossmaps are integrated into the modular simulation model (backward simulation) and in the 3D simulation model (forward simulation), which improves the simulation results. The modular simulation model calculates the optimal operation of the transmission concepts and the 3D simulation model represents the more realistic behavior of the transmission concepts. The different transmission concepts are investigated in Worldwide Harmonized Light Vehicle Test Cycle and evaluated in terms of transmission losses as well as the total energy demand. The map-based simulation model allows the transmission losses to be broken down into the individual component losses, thus allowing transmission concepts to be examined and evaluated in terms of their efficiency in the early development stage to develop optimum powertrains for electric axle drives. By considering transmission losses in detail with a high degree of accuracy, less efficient concepts can be eliminated at an early development stage. As a result, only relevant concepts are built as prototypes, which reduces development costs.
Long-Lasting Stretching Induces Muscle Hypertrophy: A Meta-Analysis of Animal Studies
Authors: Warneke Konstantin , Freund Philipp Alexander , Schiemann Stephan 
Published: October 2022

AbstractMuscular hypertrophy depends on metabolic exhaustion as well as mechanical load on the muscle. Mechanical tension seems to be the crucial factor to stimulate protein synthesis. The present meta-analysis was conducted to determine whether stretching can generate adequate mechanical tension to induce muscle hypertrophy. We used PubMed, Web of Science, and Scopus to search for literature examining the effects of long-term stretching on muscle mass, muscle cross-sectional area, fiber cross-sectional area, and fiber number. Since there was no sufficient number of studies investigating long-lasting stretching in humans, we only included original animal studies in the current meta-analysis. Precisely, we identified 16 studies meeting the inclusion criteria (e. g. stretching of at least 15 min per day). The 16 studies yielded 39 data points for muscle mass, 11 data points for muscle cross-sectional area, 20 data points for fiber cross-sectional area, and 10 data points for fiber number. Across all designs and categories, statistically significant increases were found for muscle mass (d = 8.51; 95% CI 7.11–9.91), muscle cross-sectional area (d = 7.91; 95% CI 5.75–10.08), fiber cross-sectional area (d = 5.81; 95% CI 4.32–7.31), and fiber number (d = 4.62; 95% CI 2.54–6.71). The findings show an (almost) continuous positive effect of long-term stretching on the listed parameters, so that it can be assumed that stretch training with adequate intensity and duration leads to hypertrophy and hyperplasia, at least in animal studies. A general transferability to humans—certainly with limited effectiveness—can be hypothesized but requires further research and training studies.
Three-day ceftriaxone versus longer durations of therapy for inpatient treatment of uncomplicated urinary tract infection
Authors: Elajouz Balsam , Dumkow Lisa E. , Worden Lacy J. , VanLangen Kali M. , Jameson Andrew P. 
Published: October 2022

Abstract
Current guidelines do not address a recommended duration of parenteral therapy for uncomplicated urinary tract infection (uUTI) treatment in the inpatient setting. We compared a 3-day course of ceftriaxone with longer antibiotic durations for inpatients with a uUTI. Our findings indicate that a 3-day course of ceftriaxone was as efficacious as longer antibiotic courses.
Advocacy, Misdirection, Protest, and Exit: Strategies of Aspiration and Anxiety amid Crime and Conflict in Putumayo
Authors: Arias Enrique Desmond , Duica-Amaya Liliana 
Published: October 2022

ABSTRACTThis essay examines how the inhabitants of Putumayo, a department of Colombia both divided and held together by licit and illicit authority structures and markets, engage with varied political orders as they advance individual and collective economic and political projects. Putumayo’s inhabitants adopt four basic strategies to maintain their often illicit livelihoods amid state repression. The first is intellectual resistance, wherein they develop explanations for their involvement in illicit markets that they can use to alter local and national state behavior. The second is protest, through which groups of peasants mobilize to support their illicit but socially normalized economic endeavors. A third is evasion or malicia, in which peasants seek to strategically adhere to state policy to misdirect the state as they continue to grow coca. Fourth, some peasants pursue a strategy of exit, going deeper into the jungle in search of land where they can peacefully grow coca.
The human-powered helicopter
Authors: Filippone A. 
Published: October 2022

AbstractThis paper reviews the requirements of the AHS human-powered helicopter (HPH) competition and discusses the feasibility of such a helicopter. Analysis is carried out with modified forms of the axial momentum theory to take into account the ground effect. Descent in autorotation is also considered. The main conclusions are: human-powered hover out of ground effect is not possible; the power loading decreases with the number of pedaling crew members; hover in ground effect significantly increases the rotor thrust at given power; the HPH operates in the vortex ring state; in principle, either altitude or endurance records can be reached for the AHS contest, but not both, due to insufficient power.
Spectral/hp element technology for global flow instability and control
Authors: Theofilis V. , Barkley D. , Sherwin S. 
Published: October 2022

AbstractThe objective of our paper is to demonstrate the use of spectral/hp element technology in unravelling global flow instability mechanisms. Understanding these mechanisms is central to devising flow control approaches based on theoretically-founded physical principles. Global instability theory is concerned with prediction and control of linear and nonlinear disturbances developing in flows that are inhomogeneous in more than one spatial direction. As such, this theory encompasses the classic analysis of Tollmien which is valid for simple geometries of academic interest (e.g. a flat-plate) and therefore broadens the scope of this well-established but simplified methodology to include realistic problems encountered in aeronautical engineering. Compared with a direct numerical simulation approach, global instability theory can be used to explore efficiently far wider parameters ranges and deliver physical information to be used as handle for effective flow control.
The NRL micro tactical expendable (MITE) air vehicle
Authors: Kellogg J. , Bovais C. , Foch R. , McFarlane H. , Sullivan C. , Dahlburg J. , Gardner J. , Ramamurti R. , Gordon-Spears D. , Hartley R. , Kamgar-Parsi B. , Pipitone F. , Spears W. , Sciambi A. , Srull D. 
Published: October 2022

AbstractThe US Naval Research Laboratory (NRL) is developing technologies that will enable Navy-relevant missions with the smallest practical Micro Air Vehicles (MAVs). The NRL Micro Tactical Expendable (MITE) air vehicle is a result of this research. MITE is a hand-launched, dual-propeller, fixed-wing air vehicle, with a 25cm chord and a wingspan of 25–47cm, depending on payload weight. Vehicle gross weight is 130–350g. Miniature autopilot systems, based on visual imaging techniques, are being developed for MITE. These will be used in conjunction with conventional autopilot sensors to allow the MITE to fly autonomously. This paper provides an overview of the MITE development, including aerodynamic design considerations, electric propulsion, and vision-based autopilot research. Also presented is a rationale for the development of control laws that can direct the behavior of large groups of MAVs or other vehicle agents. Dubbed ‘physicomimetics,’ this process can bring about the self-assembly of complex MAV formations, though individual MAVs have minimal onboard processing power and limited local sensing capabilities.
The use of pulse responses and system reduction for 2D unsteady flows using the Euler equations
Authors: Gaitonde A. L. , Jones D. P. 
Published: October 2022

AbstractThis paper describes the application of the theory of pulse responses to a linearised Euler scheme on a moving grid. The impulse responses of such a linear system are memory functions or temporal representations of the manner in which, and the time over which a perturbation remains active in the response of the system. The exact response of the linear system to an arbitrary input can then be predicted via convolution. The linearised Euler scheme is derived from a full nonlinear Euler method based on Jameson’s cell-centred scheme which has been modified to make it time-accurate and has the necessary terms to account for grid motion. The discrete form of the full Euler equations are linearised about the corresponding nonlinear steady mean flow assuming the unsteadiness in the flow and grid are small. The resulting set of differential equations for the flow perturbations are solved at each time step using a dual-time scheme. These equations can be easily solved to obtain pulse responses, which capture the entire frequency content of the linear system. These pulse responses then provide a simple and efficient method for calculating the system response to many different inputs via convolution. A further use of the pulse responses is their potential to allow a reduced-order linear model to be constructed, which preserves some of the accuracyof the original system. Preliminary work carried out in this area is presented. Results of calculations for heave, pitch and ramp test cases are presented.
Normal shock wave-turbulent boundary-layer interactions in the presence of streamwise slots and grooves
Authors: Smith A. N. , Babinsky H. , Fulker J. L. , Ashill P. R. 
Published: October 2022

AbstractThe effect of streamwise slots and grooves on a normal shock wave-turbulent boundary-layer interaction has been investigated experimentally at a Mach number of 1.3. The surface pressure distribution for the controlled interaction in the presence of slots featured a distinct plateau. This was due to a change in shock structure from a typical unseparated normal shock wave-boundary-layer interaction to a large bifurcated lambda type shock pattern. Velocity measurements downstream of the slots revealed a strong spanwise variation of boundary-layer properties, whereas the modified shock structure was found to be relatively two-dimensional. Cross flow measurements indicate that slots introduce streamwise vortices into the flow. When applied to an aerofoil, streamwise slots have the potential to reduce wave drag while incurring only small viscous penalties. In the presence of grooves the interaction was initially found to be significantly different. A bifurcated shock structure was observed but the trailing leg appeared stronger and featured a second lambda foot. Oil flow visualisation also revealed differences in the interactions, with the region of suction and blowing being limited to a smaller extent of the grooved control surface. The amount of crossflow present was reduced compared to the slotted control surface. By varying the internal geometry of the grooves it was found that the interaction could be modified to be similar to that in the presence of slots indicating that a more practical control device can be designed.
Frequency and distribution of dietary energy, vegetable, fruit and discretionary food intakes in 18-month-old Australian children
Authors: Chui Jie Min , Lacy Kathleen E. , Zheng Miaobing Jazzmin , Leech Rebecca M. , McNaughton Sarah A. , Spence Alison C. 
Published: October 2022

AbstractDietary behaviours in early childhood are understudied despite links with later health. Assessing the distribution of key food groups across the day could identify opportunities for improvements. This study aimed to describe the 24-hourly distribution of dietary intakes and frequency of eating occasions for weekdays and weekend days among children aged 18 months and assess associations of eating frequency with vegetable, fruit and discretionary intakes and zBMI. Using two parent-reported 24-h recalls of child dietary intakes from the Melbourne Infant Feeding Activity and Nutrition Trial (InFANT) Program, mean frequency of daily eating occasions and hourly intake distributions were calculated for vegetables, fruits, discretionary foods, and total foods and energy-containing beverages on weekdays (n 428) and weekend days (n 376). Multivariable regression analyses assessed associations between frequency of eating occasions, total intake of food groups and zBMI. Overall, children had 7·8 ± 1·8 (mean ± sd) eating occasions/d on weekdays, where 1·5 ± 0·8 contained vegetables, 2·2 ± 1·1 contained fruit and 2·5 ± 1·5 contained discretionary foods. Weekend day intakes were similar. Energy intakes were highest at dinner time. Intakes of total foods, fruits and discretionary foods were spread across the day (06.00–22.00). Vegetable consumption was mainly about 18.00 with minimal intake at other times. Eating frequency was associated with amount of food consumed but not consistently with zBMI. These 18-month-old children ate frequently throughout the day, with little distinction between weekdays and weekend days. Most eating occasions lacked vegetables, and frequency of discretionary foods was higher than of vegetables. Promoting vegetable consumption at occasions other than dinner could improve vegetable intake.