bluuebunny/crossref_metadata_2025_split huggingface dataset:
Percutaneous Cementoplasty to Treat Sternal Instability After Cardiac Surgery
Authors: Pittet Thaïs , Cook Stéphane , Khatchatourov Gregory , Theumann Nicolas 
Published: February 2022

IntroductionAlthough rare, sternal pseudarthrosis is encountered after cardiac surgery and impacts the quality of life by triggering motion-dependent chest pain. We thought to describe its treatment by percutaneous cementoplasty and report the clinical follow-up of patients treated in our institution.MethodsThis case series is a retrospective study based on five patients who benefited from a sternal cementoplasty as a treatment for symptomatic pseudarthrosis after cardiac surgery. The progression of the symptoms was assessed during clinical follow-up using the Quebec back pain disability (QBPD) scale and Visual Analog Scale (VAS).ResultsNone of the patients presented evidence of local complications or neurological disorders. The intra- et post-operative images show no major leak of the cement, no embolism and no damage to the internal mammary artery or the heart. All patients described an improved quality of life due to reduced pain in all-day clinical activities. The QBPD scores improved from 54.8 ± 29.3 to 30.0 ± 17.4 (p = 0.02) and the VAS from 7.0 ± 2.8 to 1.6 ± 1.6 (p = 0.01). Furthermore, three out of five patients could completely stop taking analgesics.ConclusionSternal pseudarthrosis is a debilitating affliction that may complicate sternotomy after cardiac surgery. This series demonstrates that a more conservative approach such as cementoplasty can be successful in terms of reducing pain, and constitutes a promising technique in selected cases.
Microplastic Distribution and Influence Factor Analysis of Seawater and Surface Sediments in a Typical Bay With Diverse Functional Areas: A Case Study in Xincun Lagoon, China
Authors: Wei Yifan , Ma Wengang , Xu Qiang , Sun Chunyang , Wang Xinyuan , Gao Fei 
Published: February 2022

Microplastics come directly or indirectly from human activities. The bay and coastal areas are constantly under pressure from human activities, including tourism, fishing, and aquaculture. Microplastic pollution is now recognized as a great threat to bay environments. In this study, we assessed microplastics in the Xincun Lagoon Bay, which had multiple human activities, to understand whether human activities could directly reflect the pollution level of microplastics. The results showed the dominant microplastics were small (100–500 μm, 45.2%) and transparent (57.0%), mainly consisting of fibers (95.7%), and cellophane (54.4%) was the dominant polymer. The color, type, and component indicated that wastes from aquaculture, laundry wastewater in the Tanka fishing raft area, and domestic wastes from tourism were the primary sources of microplastics in Xincun Bay. During the rainy season, microplastic abundances in surface water and surface sediment at the outer bay were found to be significantly higher (108.8 ± 37.1 item/L and 250.4 ± 92.0 item/kg, respectively) than those found at the inner bay (34.3 ± 12.9 item/L and 167.6 ± 71.7 item/kg, respectively), which presented a reverse trend in the dry season (p &lt; .01). Although Xincun bay has a relatively closed environment and diverse human activities, concentrated rainfall and strong winds could cause microplastic abundance inside the bay during the rainy season to be lower than that outside the bay. Furthermore, the comparison of microplastic abundances in the areas with intensive human activities and non-human activity areas indicated that the intensity of human activities could not directly reflect the pollution of microplastics in the lagoon bay. It is also necessary to consider the geographical and seasonal characteristics in order to explain the pollution degree of microplastics in a bay.
Specific IgE and IgG4 Profiles of House Dust Mite Components in Allergen-Specific Immunotherapy
Authors: Yang Lin , Yang Yaqi , Xu Qingxiu , Zhang Wei , Jiang Qing , Li Wenjing , Wang Yin , Ma Dongxia , Lin Xiaomin , Sun Baoqing , Zhu Rongfei 
Published: February 2022

BackgroundAllergen immunotherapy (AIT) can induce immune tolerance to allergens by activating multiple mechanisms, including promoting IgG4 synthesis and blunting IgE production. However, the longitudinal data of sIgE and sIgG4 to allergen components during AIT are limited.ObjectiveWe sought to investigate the persistence and evolution of sIgE and sIgG4 against house dust mite (HDM) components during AIT and explore their correlation with clinical responses.MethodsSixty allergic rhinitis (AR) with/without asthma patients receiving AIT for HDM were enrolled in AIT group. Thirty AR patients without receiving AIT served as control group. Blood samples were collected for sIgE, sIgG4 to HDM components (Derp 1, Derf 1, Derp 2, Derf 2, Derp 7, Derp 10, Derp 21 and Derp 23) assay at baseline, Month 6 and Month 18 of AIT. Combined symptom and medication scores (CSMS) were obtained accordingly.ResultsIn the AIT group, sIgG4 to the HDM components of Derp 1, Derf 1, Derp 2 and Derf 2, Derp 21 significantly increased at Month 18 compared to the baseline (36.2 UA/mL vs 158.8 UA/mL, 46.4 UA/mL vs 94.6 UA/mL, 80.5 UA/mL vs 152.3 UA/mL, 78.3 UA/mL vs 205.1 UA/mL, 42.3 UA/mL vs 59.3 UA/mL, all p&lt;0.05), sIgE to HDM components didn’t see differences at baseline and at Month 18 (all p&gt;0.05).The numbers of positive HDM component sIgE and sIgG4 increased from 4.5 to 5 and 0 to 1.5 respectively (both p&lt;0.05). However, the changes of sIgE, sIgG4, sIgE/sIgG4 ratio and the numbers of positive HDM components had no correlations with the improvement of CSMS after AIT (all ρ&lt;0.3). For the control group, the sIgE and sIgG4 did not change significantly during the observational period (all p&gt;0.05).ConclusionAIT can induce the production of sIgG4 to HDM components. However, the increased sIgG4 levels of HDM component do not correlate with the corresponding sIgE levels at baseline or with AIT response. sIgG4 to HDM components do not qualify as a biomarker to evaluate the efficacy of AIT.
Functional Interactions Between lncRNAs/circRNAs and miRNAs: Insights Into Rheumatoid Arthritis
Authors: Han Juan-Juan , Wang Xue-Qiang , Zhang Xin-An 
Published: February 2022

Rheumatoid arthritis (RA) is one of the most common autoimmune diseases that affect synovitis, bone, cartilage, and joint. RA leads to bone and cartilage damage and extra-articular disorders. However, the pathogenesis of RA is still unclear, and the lack of effective early diagnosis and treatment causes severe disability, and ultimately, early death. Accumulating evidence revealed that the regulatory network that includes long non-coding RNAs (lncRNAs)/circular RNAs (circRNAs), micro RNAs (miRNAs), and messenger RNAs (mRNA) plays important roles in regulating the pathological and physiological processes in RA. lncRNAs/circRNAs act as the miRNA sponge and competitively bind to miRNA to regulate the expression mRNA in synovial tissue, FLS, and PBMC, participate in the regulation of proliferation, apoptosis, invasion, and inflammatory response. Thereby providing new strategies for its diagnosis and treatment. In this review, we comprehensively summarized the regulatory mechanisms of lncRNA/circRNA-miRNA-mRNA network and the potential roles of non-coding RNAs as biomarkers and therapeutic targets for the diagnosis and treatment of RA.
Modified Long-Axis In-plane Technique for Radial Artery Cannulation in Children: A Randomized Controlled Trial
Authors: Yu Liu , Zhong Heying , Jiang Yan , Zhang Wangping , Liu Zhiwei 
Published: February 2022

BackgroundRadial artery catheterization is a challenge for anesthetists in the pediatric population. The purpose of this study was to determine whether the modified long-axis in-plane (MLAX-IP) technique increased the success rate of radial artery catheterization in children.MethodsThis study involved 80 children who required arterial catheterization and were randomly divided into the MLAX-IP group and dynamic needle tip positioning (DNTP) group (40 cases in each group). Radial artery catheterization was performed using either the MLAX-IP technique or the DNTP technique.ResultsThe first-attempt cannulation success rate was higher in the MLAX-IP group than in the DNTP group (95 vs. 80%, P = 0.043). The imaging time of the artery in the MLAX-IP group was longer than in the DNTP group (19.1 ± 3.1 vs. 9.6 ± 2.4 s, P &lt; 0.001). While the total catheterization time was similar between the 2 groups (88.1 ± 23 vs. 86.9 ± 46.1 s, P = 0.475).ConclusionThe first-attempt cannulation success rate with the MLAX-IP technique is increased, while the total catheterization time is similar between the 2 groups and puncture-related complications are fewer.
Efficacy and Safety of Finerenone in Chronic Kidney Disease: A Systematic Review and Meta-Analysis of Randomized Clinical Trials
Authors: Zhang Ming-Zhu , Bao Wujisiguleng , Zheng Qi-Yan , Wang Ya-Hui , Sun Lu-Ying 
Published: February 2022

Background: Chronic kidney disease (CKD) is a global public health issue. In recent years, the effectiveness of finerenone for treatment of CKD has been the subject of considerable debate. The main objective of the current meta-analysis was to validate the clinical efficacy and safety of finerenone in patients with CKD.Methods: Seven databases were searched for randomized controlled trials (RCTs) comparing finerenone with placebo in patients with CKD. Data from eligible studies were extracted, and the Cochrane risk of bias tool utilized for evaluating the methodological quality of RCTs. The effect size was estimated using the risk ratio (RR) and mean difference (MD) with 95% confidence interval (CI).Results: Five trials (n = 13,078) were included. Compared to placebo groups, the urinary albumin-to-creatinine ratio (UACR) mean from the baseline was significantly lower [MD −0.30 (95% CI −0.32, −0.28), p &lt; 0.00001], while a decrease in the estimated glomerular filtration rate (eGFR) from baseline was significantly higher [MD −2.44 (95% CI −2.82, −2.05), p &lt; 0.00001] for the finerenone groups. Furthermore, the proportion of patients with decreased eGFR (≥40%) post-baseline was significantly lower [RR 0.85 (95% CI 0.78, 0.93), p = 0.0002], along with end-stage kidney disease (ESKD) [RR 0.80 (95% CI 0.65, 0.99), p = 0.04] and cardiovascular events (CVs) [RR 0.88 (95% CI 0.80, 0.95), p &lt; 0.003] in the finerenone groups. In terms of safety, the increase in the serum potassium concentration and incidence of hyperkalemia was significantly higher for the finerenone groups [MD 0.17 (95% CI 0.10, 0.24), p &lt; 0.00001; RR 2.03 (95% CI 1.83, 2.26), p &lt; 0.00001, respectively], but the incidence of adverse events (AEs) was similar to placebo [RR 1.00 (95% CI 0.98–1.01), p = 0.67]. In all cases, the results were rated as providing moderate-quality or high-quality evidence.Conclusion: Data from our meta-analysis suggest that finerenone confers significant renal and cardiovascular benefits in patients with CKD. While higher risk of hyperkalemia was observed with finerenone than placebo, differences in AEs were not significant. Finerenone may therefore present a novel promising therapeutic agent for patients with CKD.Systematic Review Registration: [https://inplasy.com/inplasy-2021-9-0020/], identifier [INPLASY202190020].
Reversed Apico-Basal Myocardial Relaxation Sequence During Exercise in Long QT Syndrome Mutations Carriers With History of Previous Cardiac Events
Authors: Charisopoulou Dafni , Koulaouzidis George , Rydberg Annika , Henein Michael Y. 
Published: February 2022

BackgroundRecent echocardiography studies in inherited long QT syndrome (LQTS) have shown left ventricular (LV) myocardial relaxation disturbances to follow markedly prolonged and dispersed mechanical contraction.AimWe used speckle-tracking echocardiography to assess disturbances in LV myocardial relaxation sequence during exercise and their relationship to symptoms.MethodsForty seven LQTS patients (45 ± 15 years, 25 female and 20 symptomatic, LVEF: 65 ± 6%) and 35 controls underwent exercise echocardiogram using Bruce protocol. ECG and echo parameters were recorded at rest, peak exercise (p.e.) and recovery.ResultsBetween patients and controls there were no differences in age, gender, HR or LVEF. At p.e, patients had longer time to LV longitudinal ESR(tESR) at all three LV segments; basal (p&lt; 0.0001), mid- cavity (p= 0.03) and apical (p= 0.03) whereas at rest such difference was noted only at base (p= 0.0007). Patients showed reversed apico-basal relaxation sequence (ΔtESRbase–apex) with early relaxation onset occurring later at base than at apex, both at rest (49 ± 43 vs. –29 ± 19 ms,p&lt; 0.0001) and at p.e. (46 ± 38 vs. –40 ± 22 ms,p&lt; 0.0001), particularly in symptomatic patients (69 ± 44 vs. 32 ± 26,p&lt; 0.0007). ΔtESRbase–apexcorrelated with longer QTc interval, lower ESRand attenuated LV stroke volume.ConclusionLQTS patients show reversed longitudinal relaxation sequence, which worsens with exercise, particularly in those with previous cardiac events.
An Evaluation of an Online Training Platform for Teaching Positive Emotions for People With Schizophrenia
Authors: Nguyen Alexandra , Frobert Laurent , Kollbrunner Aurélien , Favrod Jérôme 
Published: February 2022

BackgroundThe dissemination of new interventions in clinical practice remains challenging. E-learning may provide wide access in various settings and allow tailored learning trajectories and an adapted training pace. This study evaluates an online platform to train professionals to lead the Positive Emotion Program for Schizophrenia (PEPS) for patients with anhedonia. This study aims to test the reception provided by clinicians to the platform and its perceived usefulness and investigate whether e-PEPS training improves knowledge about the facilitation of PEPS.Materials and MethodsParticipants were recruited through advertisements. All participants provided their informed consent on a registration form and completed two pre-test questionnaires, a knowledge test on negative symptoms in schizophrenia, learning strategies and the partnership relationship, and a test on the ability to savor pleasant moments. After the training, they completed the same questionnaire and an evaluation form of the training and its application in personal and professional life.ResultsTwo-hundred and ten participants were registered to participate into the study, 185 received the access to the platform, and 101 participants completed the training and the post-test assessments. Satisfaction with training was high. The results showed that the participants significantly improved their knowledge about PEPS and increased the skills taught in their personal repertoire after the training. The training allows most clinicians to plan to lead a PEPS group in the year following training.DiscussionAs a result of this study, training has been improved and is now freely available to all interested clinicians.
Effort-Reward Imbalance in Emergency Department Physicians: Prevalence and Associated Factors
Authors: Tian Mengge , Zhou Xuan , Yin Xiaoxv , Jiang Nan , Wu Yafei , Zhang Jiali , Lv Chuanzhu , Gong Yanhong 
Published: February 2022

ObjectivesTo examine the prevalence of effort-reward imbalance and explore its associated factors among emergency department physicians in China.MethodsA cross-sectional survey was conducted in the Chinese emergency department in 2018. A total of 10,457 emergency department physicians completed a structured questionnaire containing demographic characteristics, work-related data, and effort-reward imbalance scale. All the data were analyzed using descriptive analysis and stepwise logistic regression.ResultsThe prevalence of effort-reward imbalance was 78.39% among emergency department physicians in China. The results showed that the male emergency department physicians with a bachelor's degree, an intermediate title, long years of service, a high frequency of night shift, and who suffered workplace violence were at a higher risk of effort-reward imbalance. In contrast, physicians with higher monthly income and perceived adequate staff were associated with a lower risk of effort-reward imbalance.ConclusionsThe situation of effort-reward imbalance was serious among emergency department physicians in China. Administrators should pay more attention to key groups and take measures from the perspectives of effort and reward to improve the effort-reward imbalance in emergency department physicians.
COVID-19 in German Competitive Sports: Protocol for a Prospective Multicenter Cohort Study (CoSmo-S)
Authors: Niess Andreas Michael , Widmann Manuel , Gaidai Roman , Gölz Christian , Schubert Isabel , Castillo Katty , Sachs Jan Philipp , Bizjak Daniel , Vollrath Shirin , Wimbauer Fritz , Vogel Azin , Keller Karsten , Burgstahler Christof , Quermann Anne , Kerling Arno , Schneider Gerald , Zacher Jonas , Diebold Katharina , Grummt Maximilian , Beckendorf Claudia , Buitenhuis Johannes , Egger Florian , Venhorst Andreas , Morath Oliver , Barsch Friedrich , Mellwig Klaus-Peter , Oesterschlink Julian , Wüstenfeld Jan , Predel Hans-Georg , Deibert Peter , Friedmann-Bette Birgit , Mayer Frank , Hirschmüller Anja , Halle Martin , Steinacker Jürgen Michael , Wolfarth Bernd , Meyer Tim , Böttinger Erwin , Flechtner-Mors Marion , Bloch Wilhelm , Haller Bernhard , Roecker Kai , Reinsberger Claus 
Published: February 2022

Objective: It is unclear whether and to what extent COVID-19 infection poses health risks and a chronic impairment of performance in athletes. Identification of individual health risk is an important decision-making basis for managing the pandemic risk of infection with SARS-CoV-2 in sports and return to play (RTP).Methods: This study aims 1) to analyze the longitudinal rate of seroprevalence of SARS-CoV-2 in German athletes, 2) to assess health-related consequences in athletes infected with SARS-CoV-2, and 3) to reveal effects of the COVID-19 pandemic in general and of a cleared SARS-CoV-2 infection on exercise performance. CoSmo-S is a prospective observational multicenter study establishing two cohorts: 1) athletes diagnosed positive for COVID-19 (cohort 1) and 2) federal squad athletes who perform their annual sports medical preparticipation screening (cohort 2). Comprehensive diagnostics including physical examination, laboratory blood analyses and blood biobanking, resting and exercise electrocardiogram (ECG), echocardiography, spirometry and exercise testing added by questionnaires are conducted at baseline and follow-up.Results and Conclusion: We expect that the results obtained, will allow us to formulate recommendations regarding RTP on a more evidence-based level.
The Influence of Diabetes Mellitus on the Risks of End-Stage Kidney Disease and Mortality After Liver Transplantation
Authors: Lee Chung-Ying , Wu Mei-Yi , Chan Hsiu-Chen , Chen Tzu-Ting , Hsu Le-Yin , Wu Mai-Szu , Cherng Yih-Giun 
Published: February 2022

This retrospective study aimed to investigate the effect of diabetes mellitus (DM) on the risks of end-stage kidney disease (ESKD) and post-liver transplantation (post-LT) mortality. Using data from the National Health Insurance Research Database, Taiwan, 3,489 patients who received a LT between 1 January 2005, and 31 December 2015, were enrolled in this study and divided into the pre-existing DM, post-LT DM (PLTDM), and without DM groups. All subjects were followed up from 1 year after LT to the index date for ESKD, and the occurrence of death, or until 31 December 2016. Of the 3,489 patients with LT, 1,016 had pre-existing DM, 215 had PLTDM, and 2,258 had no DM pre- or post-LT. The adjusted HRs of ESKD were 1.77 (95% Confidence Interval [CI], .78–3.99) and 2.61 (95% CI, 1.63–4.18) for PLTDM group and pre-existing DM group compared to without DM group, respectively. For the risk of death, the adjusted HRs were 1.05 (95% CI, .72–1.55) and 1.28 (95% CI, 1.04–1.59) for PLTDM group and pre-existing DM group compared to those without DM group, respectively. The sensitivity analysis for the risk of ESKD and death also revealed the consistent result. Pre-existing DM has significant increase the risk of post-LT ESKD and mortality. The role of PLTDM should be explored to explain postoperative morbidity and mortality.
Hubungan Perilaku Dan Kualitas Fisik Rumah Dengan Kejadian Tbc Paru Di Wilayah Kerja Puskesmas Kediri 1 Tahun 2020
Authors: Pratiwi AA Istri Ratih Dwi , Sudiadnyana I Wayan 
Published: February 2022

Abstract:. The increase in cases of pulmonary tuberculosis in a region is caused by physical quality factors of the house and behavioral factors. The purpose research was to determine the relationship between behavior and physical quality of the home with the incidence of pulmonary tuberculosis in the Kediri Community Health Center 1. The type of observational research was retrospective with a case control design. Case group samples were 40 tuberculosis patients at the Kediri Health Center 1 in 2018. Samples of the control group were 40 people who had never suffered from tuberculosis and had the characteristics of a case group. Data collection used questionnaire sheets for behavior and observation sheets for the physical quality of the house and analyzed with chi square statistical test. Based on the results of the chi square test showed there is a relationship between behavior (p = 0,000 CC = 0,363) and physical quality of the house (p = 0,000 CC = 0,430) with the incidence of pulmonary tuberculosis. Suggestions that for the community to pay more attention to the health and cleanliness of the house
ANALISIS FAKTOR YANG MEMPENGARUHI PERPINDAHAN MEREK (BRAND SWITCHING) PENGGUNA JARINGAN OPERATOR TRI KE OPERATOR LAIN DI MASA PEMBELAJARAN ONLINE SAAT PANDEMI COVID -19
Authors: Chusnah Chusnah , Zahratunnisa Zahratunnisa 
Published: February 2022

This researchs purpose to know some factors that influence brand switching Tri operator user to another operator and get result from the pre-survey include the ef ect of product atribute, variety seeking, promotion and price on brand switching. Thisresearch obtained via by questionnaire to 96 respondents which become Tri operator user to students at the As- syafi'iyah Islamic University with population 3.850. Analyst data method that used is regression analysis, correlation, coef icient of determination and hypothesis test. Based on analyst data result, partially product attributes give positive and significant ef ect on brand switching. Variety seeking give positive and significant ef ect on brand switching. Promotion give ositive and significant ef ect on brand switching. Price give positive and significant ef ect on brand switching.
PENGARUH KUALITAS PELAYANAN DAN WORD OF MOUTH ( WOM ) TERHADAP KEPUTUSAN PEMBELIAN
Authors: Herawati Heny 
Published: February 2022

This study aims to determine the influence of Service Quality and Word of Mouth (WOM) on Purchasing Decisions at PT. Hijrah Insan Karima because at this time there have been many threats and competitors in the world of selling concrete and baja ringan iron. The subject in this study was the Histeel company that had been established since 2008. The total population studied in this study was 465,000 respondents. The sampling technique uses slovin formula and obtained a sample of 100 respondents, namely consumers PT. Hijrah Insan Karima. The statistical methods used in this study are the Classical Assumption test, Regression Analysis, Correlation Analysis, and Hypothesis Test. The analytical tool used in this study is SPSS version 21. The results of this study indicate that Service Quality and Word of Mouth (WOM) simultaneously have a significant effect on purchasing decisions. Tested with multiple correlations, there is a simultaneous contribution value of R = 0.592 or 59.2% influential and 40.8% influenced by other variables and the results of the t test sig X1 value of 0.006 <0.05 and X2 of 0.000 <0.05 means Service Quality and Word of Mouth (WOM) variables influence Purchasing Decisions.