bluuebunny/crossref_metadata_2025_split huggingface dataset:
Jan Mayen—a new spawning and fishing area for Atlantic cod Gadus morhua
Authors: Bogstad Bjarte 
Published: December 2022

AbstractIn 2018, commercially exploitable concentrations of Atlantic cod Gadus morhua were found on the shelf around the Arctic island Jan Mayen (7 1°N, 8–9 °W) and in 2019–2021 an exploratory cod fishery with longline was carried out in the area. The total catch in the period 2018–2021 was 1737 tonnes. The first records of cod fishery in the Jan Mayen area are from the early 1930s but catches before 2018 were minimal. In 2019–2020 cod spawning was documented in this area for the first time. Catches in 2019 and 2020 were dominated by cod between 70 and 100 cm, while in 2021 the main part of the catches was cod between 60 and 100 cm. Catch rates were highest in autumn. We summarize the history of cod observations and the experience from the recent exploratory fishery in this shelf area where there has been no regular monitoring of demersal fish abundance. Further, we consider possible links with cod stocks in other Arctic and sub-Arctic areas and discuss the occurrence of cod in the Jan Mayen area in relation to the biology and recent development of other cod stocks.
Efficacy and safety of oral and sublingual versus vaginal misoprostol for induction of labour: a systematic review and meta-analysis
Authors: Pergialiotis Vasilios , Panagiotopoulos Michail , Constantinou Therapon , Vogiatzi Vokotopoulou Lito , Koumenis Andreas , Stavros Sofoklis , Voskos Andreas , Daskalakis George 
Published: December 2022

AbstractObjectiveMisoprostol is a synthetic PGE1analogue that is used for induction of labour. Current guidelines support the use of doses that do not exceed 25 mcg in order to limit maternal and neonatal adverse outcomes. The present meta-analysis investigates the efficacy and safety of oral compared to vaginally inserted misoprostol in terms of induction of labor and adverse peripartum outcomes.MethodsWe searched Medline, Scopus, the Cochrane Central Register of Controlled Trials CENTRAL, Google Scholar, and Clinicaltrials.gov databases from inception till April 2022. Randomized controlled trials that assessed the efficacy of oral misoprostol (per os or sublingual) compared to vaginally inserted misoprostol. Effect sizes were calculated in R. Sensitivity analysis was performed to evaluate the possibility of small study effects, p-hacking. Meta-regression and subgroup analysis according to the dose of misoprostol was also investigated. The methodological quality of the included studies was assessed by two independent reviewers using the risk of bias 2 tool. Quality of evidence for primary outcomes was evaluated under the Grading of Recommendations Assessment, Development and Evaluation (GRADE) framework, ranging from very low to high.ResultsOverall, 57 studies were included that involved 10,975 parturient. Their risk of bias ranged between low-moderate. There were no differences among the routes of intake in terms of successful vaginal delivery within 24 h (RR 0.90, 95% CI 0.80) and cesarean section rates (RR 0.92, 95% CI 0.82, 1.04). Sublingual misoprostol was superior compared to vaginal misoprostol in reducing the interval from induction to delivery (MD – 1.11 h, 95% CI – 2.06, – 0.17). On the other hand, per os misoprostol was inferior compared to vaginal misoprostol in terms of this outcome (MD 3.45 h, 95% CI 1.85, 5.06). Maternal and neonatal morbidity was not affected by the route or dose of misoprostol.ConclusionThe findings of our study suggest that oral misoprostol intake is equally safe to vaginal misoprostol in terms of inducing labor at term. Sublingual intake seems to outperform the per os and vaginal routes without increasing the accompanying morbidity. Increasing the dose of misoprostol does not seem to increase its efficacy.Clinical trial registrationOpen Science Framework (https://doi.org/10.17605/OSF.IO/V9JHF).
White matter hyperintensities are an independent predictor of cognitive decline 3 years following first-ever stroke—results from the PROSCIS-B study
Authors: Ali Huma Fatima , Fast Lea , Khalil Ahmed , Siebert Eberhard , Liman Thomas , Endres Matthias , Villringer Kersten , Kufner Anna 
Published: December 2022

Abstract
Background
White matter hyperintensities (WMH) are the result of cerebral small vessel disease and may increase the risk of cognitive impairment (CI), recurrent stroke, and depression. We aimed to explore the association between selected cerebrovascular risk factors (CVRF) and WMH load as well as the effect of increased WMH burden on recurrent vascular events, CI, and depression in first-ever ischemic stroke patients.

Methods
431 from the PROSpective Cohort with Incident Stroke (PROSCIS) were included; Age-Related White Matter Changes (ARWMC) score was used to assess WMH burden on FLAIR. The presence of CVRF (defined via blood pressure, body-mass-index, and serological markers of kidney dysfunction, diabetes mellitus, and hyperlipoproteinemia) was categorized into normal, borderline, and pathological profiles based on commonly used clinical definitions. The primary outcomes included recurrent vascular events (combined endpoint of recurrent stroke, myocardial infarction and/or death), CI 3 years post-stroke, and depression 1-year post-stroke.

Results
There was no clear association between CVRF profiles and WMH burden. High WMH lesion load (ARWMC score ≥ 10) was found to be associated with CI (adjusted OR 1.05 [95% CI 1.00–1.11]; p < 0.02) in a mixed-model analysis. Kaplan–Meier survival analysis showed a visible increase in the risk of recurrent vascular events following stroke; however, after adjustment, the risk was non-significant (HR 1.5 [95% CI 0.76–3]; p = 0.18). WMH burden was not associated with depression 1-year post stroke (adjusted OR 0.72 [95% CI 0.31–1.64]; p = 0.44).

Conclusion
Higher WMH burden was associated with a significant decline in cognition 3 years post-stroke in this cohort of first-ever stroke patients.
Predictors and reasons for epilepsy patients to decline surgery: a prospective study
Authors: Steinbrenner Mirja , Tito Tabea , Dehnicke Christoph , Holtkamp Martin 
Published: December 2022

AbstractBackgroundIn patients with drug-resistant focal epilepsy, resective surgery is the most successful treatment option to achieve seizure freedom. However, a surprisingly high rate of patients declines their physicians’ recommendation to undergo removal of the seizure focus or—if necessary—further video-EEG monitoring (VEM).MethodsIn this prospective study, consecutive patients in presurgical assessment with at least one scalp VEM between 2016 and 2018 were included. We assessed both epilepsy-related and psychosocial variables as well as decision-making of physicians and patients, including reasons for decline in the latter.ResultsOut of 116 patients with a total of 165 VEM, 20 patients were eventually found to be ineligible for resection, 51 declined, and 45 agreed on recommendations for resection or further VEM diagnostics. Patients most frequently declined due to general fear of brain surgery (n = 30, 59%) and currently lower seizure frequency (n = 11, 22%). An independent predictor of patients’ decline was less epilepsy-related fear (OR 0.43;p = 0.02) assessed in a standardised questionnaire.ConclusionHalf of the patients potentially eligible for resective surgery decline the operation or further VEM procedures. Patients who decline are more fearful of brain surgery than of ongoing disabling seizures. More insight is needed to improve counselling of patients.
The value of modified Ross score in the evaluation of children with severe lower respiratory tract infection admitted to the pediatric intensive care unit
Authors: Hassan Enas Saad , Ahmad Salah-Eldin Amry , Mohamad Ismail Lotfy , Ahmad Faisal-Alkhateeb 
Published: December 2022

AbstractHeart failure (HF) represents an important cause of morbidity and mortality in children. It is mostly caused by congenital heart disease (CHD) and cardiomyopathy. The Ross HF classification was developed to assess severity in infants and has subsequently been modified to apply to all pediatric ages. The modified Ross classification for children provides a numeric score comparable with the New York Heart Association (NYHA) HF classification for adults. The aim of this work is to investigate the role of modified Ross score in the evaluation of children with severe lower respiratory tract infection admitted to the pediatric intensive care unit (PICU). One hundred and sixty-four children with severe LRTI admitted to the PICU were enrolled in this prospective cohort study, which was carried out at Assiut University Children Hospital, from the start of July 2021 up to the end of December 2021. Sixty patients (36.6%) of studied cases with severe LRTI admitted to PICU had HF. Out of these, 37 (61.7%) had mild HF; 17 (28.3%) had moderate HF, while six cases (10%) had severe HF according to the modified Ross score. The value of modified Ross score was significantly higher in children with heart failure with sensitivity and specificity 100% with cutoff value of 2. Admission to NICU, history of previous ventilation, and prematurity were higher in patients who developed HF. Patients with pulmonary hypertension (PH) and those with raised neutrophil lymphocyte ratio were significantly higher in the group of patients with moderate and severe degree of HF. Conclusion: Modified Ross score is a simple clinical score which may help in assessing and predicting children with severe LRTI.

What is Known:• Hear failure is common complication to lower respiratory tract infection.• Modified Ross score was used to predict and classify heart failure in adult with lower respiratory infection.

What is New:• Modified Ross score found to be of value in prediction of heart failure in children with lower respiratory tract infection.
Interactive webtool for analyzing drug sensitivity and resistance associated with genetic signatures of cancer cell lines
Authors: Boeschen Myriam , Le Duc Diana , Stiller Mathias , von Laffert Maximilian , Schöneberg Torsten , Horn Susanne 
Published: December 2022

Abstract
Purpose
A wide therapeutic repertoire has become available to oncologists including radio- and chemotherapy, small molecules and monoclonal antibodies. However, drug efficacy can be limited by genetic heterogeneity. Here, we designed a webtool that facilitates the data analysis of the in vitro drug sensitivity data on 265 approved compounds from the GDSC database in association with a plethora of genetic changes documented for 1001 cell lines in the CCLE data.

Methods
The webtool computes odds ratios of drug resistance for a queried set of genetic alterations. It provides results on the efficacy of single compounds or groups of compounds assigned to cellular signaling pathways. Webtool availability: https://tools.hornlab.org/GDSC/.

Results
We first replicated established associations of genetic driver mutations in BRAF, RAS genes and EGFR with drug response. We then tested the ‘BRCAness’ hypothesis and did not find increased sensitivity to the assayed PARP inhibitors. Analyzing specific PIK3CA mutations related to cancer and mendelian overgrowth, we found support for the described sensitivity of H1047 mutants to GSK690693 targeting the AKT pathway. Testing a co-mutated gene pair, GATA3 activation abolished PTEN-related sensitivity to PI3K/mTOR inhibition. Finally, the pharmacogenomic modifier ABCB1 was associated with olaparib resistance.

Conclusions
This tool could identify potential drug candidates in the presence of custom sets of genetic changes and moreover, improve the understanding of signaling pathways. The underlying computer code can be adapted to larger drug response datasets to help structure and accommodate the increasingly large biomedical knowledge base.
Pre-eruptive Conditions of the 3 March 2015 Lava Fountain of Villarrica Volcano (Southern Andes)
Authors: Romero Jorge E. , Morgado Eduardo , Pisello Alessandro , Boschetty Felix , Petrelli Maurizio , Cáceres Francisco , Alam Mohammad Ayaz , Polacci Margherita , Palma José L. , Arzilli Fabio , Vera Franco , Gutiérrez Romina , Morgavi Daniele 
Published: December 2022

Abstract
Villarrica or Rukapillan (35.9°S; 2,847 m a.s.l.) is one of the most active volcanoes in South America and is the highest-risk volcano in Chile. It has an open conduit with a persistent lava lake. On the 3 March 2015, Strombolian activity rapidly progressed into a 1.5-km-high lava fountain, erupting at least ∼ 2.4 × 106 m3 of tephra. Soon after, the activity returned to mild Strombolian “background” explosions, which lasted until early 2017. Understanding the pre-eruptive conditions of such paroxysmal events is fundamental for volcanic hazard assessment. We present major and trace element geochemistry for glass and crystalline phases of basaltic andesite paroxysm pyroclasts (52–56 wt.% SiO2), and for the subsequent Strombolian “background” activity through February 2017 (54–56 wt.% SiO2). The lava fountain source magma was initially stored in a deeper and hotter region (9.4–16.3 km; ca. 1140 °C) and was then resident in a shallow (≤ 0.8 km) storage zone pre-eruption. During storage, crystallising phases comprised plagioclase (An66–86), olivine (Fo75–78) and augite (En46–47). Equilibrium crystallisation occurred during upper-crustal magmatic ascent. During storage in the shallower region, magma reached H2O saturation, promoting volatile exsolution and over-pressurization, which triggered the eruption. In contrast, subsequent “background” explosions involving basaltic-andesite were sourced from a depth of ≤ 5.3 km (ca. 1110 °C). Pre-eruptive conditions for the 2015 lava fountain contrast with historical twentieth-century eruptions at Villarrica, which were likely driven by magma that underwent a longer period of mixing to feed both effusive and explosive activity. The rapid transition to lava-fountaining activity in 2015 represents a challenging condition in terms of volcano monitoring and eruption forecasting. However, our petrological study of the pyroclastic materials that erupted in 2015 offers significant insights into eruptive processes involving this type of eruption. This aids in deciphering the mechanisms behind sudden eruptions at open conduit systems.
Survival and stability of strategic mini-implants with immediate or delayed loading under removable partial dentures: a 3-year randomized controlled clinical trial
Authors: Mundt Torsten , Heinemann Friedhelm , Müller Janine , Schwahn Christian , Al Jaghsi Ahmad 
Published: December 2022

Abstract

Objectives
Stability values of mini-implants (MIs) are ambiguous. Survival data for MIs as supplementary abutments in reduced dentitions are not available. The aim of this explorative research was to estimate the 3-year stability and survival of strategic MIs after immediate and delayed loading by existing removable partial dentures (RPDs).

Material and methods
In a university and three dental practices, patients with unfavorable tooth distributions received supplementary MIs with diameters of 1.8, 2.1, and 2.4 mm. The participants were randomly allocated to group A (if the insertion torque ≥ 35 Ncm: immediate loading by housings; otherwise, immediate loading by RPD soft relining was performed) or delayed loading group B. Periotest values (PTVs) and resonance frequency analysis (RFA) values were longitudinally compared using mixed models.

Results
A total of 112 maxillary and 120 mandibular MIs were placed under 79 RPDs (31 maxillae). The 1st and 3rd quartile of the PTVs ranged between 1.7 and 7.8, and the RFA values ranged between 30 and 46 with nonrelevant group differences. The 3-year survival rates were 92% in group A versus 95% in group B and 99% in the mandible (one failure) versus 87% in the maxilla (eleven failures among four participants).

Conclusions
Within the limitations of explorative analyses, there were no relevant differences between immediate and delayed loading regarding survival or stability of strategic MIs.

Clinical relevance
The stability values for MIs are lower than for conventional implants. The MI failure rate in the maxilla is higher than in the mandible with cluster failure participants.

Clinical trial registration
German Clinical Trials Register (Deutsches Register Klinischer Studien, DRKS-ID: DRKS00007589, www.germanctr.de), January 15, 2015.
Towards a Benchmark for Shared Databases [Vision Paper]
Authors: El-Hindi Muhammad , Arora Ashwin , Karrer Simon , Binnig Carsten 
Published: December 2022

AbstractTraditionally, data has been held in silos and was rarely shared with other organizations. However, recently data sharing across organizations is becoming more and more important as evidenced by governmental and industrial initiatives such as the EU data strategy. As a result, both academia and industry have been proposing new systems for shared databases, that allow multiple organizations to collaboratively insert and manage data in a common database. Yet, each new system seems to come with its own architectural choices and custom guarantees that make it hard for users to navigate the plethora of shared database systems. While standard benchmarks like the TPC‑C database benchmark have been a well-established tool to compare and analyze traditional database systems, they seem to be unsuited to evaluate shared database systems. This is because these systems are built with fundamentally different assumptions in mind, such as a different threat/trust model since multiple (untrusted) parties access and modify the same data. In this paper, we present a vision and initial ideas for a new benchmark to evaluate shared databases and capture their unique characteristics.
Correlating the Interfacial Polar-Phase Structure to the Local Chemistry in Ferroelectric Polymer Nanocomposites by Combined Scanning Probe Microscopy
Authors: Liang Jiajie , Wang Shaojie , Luo Zhen , Fu Jing , Hu Jun , He Jinliang , Li Qi 
Published: December 2022

AbstractFerroelectric polymer nanocomposites possess exceptional electric properties with respect to the two otherwise uniform phases, which is commonly attributed to the critical role of the matrix–particle interfacial region. However, the structure–property correlation of the interface remains unestablished, and thus, the design of ferroelectric polymer nanocomposite has largely relied on the trial-and-error method. Here, a strategy that combines multi-mode scanning probe microscopy-based electrical characterization and nano-infrared spectroscopy is developed to unveil the local structure–property correlation of the interface in ferroelectric polymer nanocomposites. The results show that the type of surface modifiers decorated on the nanoparticles can significantly influence the local polar-phase content and the piezoelectric effect of the polymer matrix surrounding the nanoparticles. The strongly coupled polar-phase content and piezoelectric effect measured directly in the interfacial region as well as the computed bonding energy suggest that the property enhancement originates from the formation of hydrogen bond between the surface modifiers and the ferroelectric polymer. It is also directly detected that the local domain size of the ferroelectric polymer can impact the energy level and distribution of charge traps in the interfacial region and eventually influence the local dielectric strength.
Modelling land suitability to evaluate the potential for irrigated agriculture in the Nile region in Sudan
Authors: Kau Anna-Sonia , Gramlich Richard , Sewilam Hani 
Published: December 2022

AbstractThe Nile River serves as a central source of water for around 487 million people. Agriculture in the riparian states largely depends on the Nile's water supply due to irrigation. In this study, the potential for irrigated agriculture in Sudan is evaluated to estimate the future increase in water pressure in the region. In geographic information system (GIS) software a model for land suitability analysis (LSA) is developed. Datasets of parameters such as precipitation, temperature, slope, landcover, and selected soil properties represent the prevailing conditions. The resulting maps of the LSA show suitable and not suitable areas for irrigated agriculture. To determine the yearly water demand for irrigated agriculture the suitable areas are offset by the irrigation water demand for mixed cultivation of Faba beans, sorghum, and sugarcane calculated with the Food and Agriculture Organization of the United States (FAO) software AquaCrop. It shows that there is great potential for irrigated agriculture, especially in the southeast, where large irrigation schemes already exist. In northern Sudan, not suitable areas accumulate. The calculated irrigation water demand is 33.5 BCM/year, which is 19.5 BCM/year additionally compared to 2017. The estimated irrigation amount shows the importance of collaboration between the countries in the Nile basin to increase the water resources available for irrigation to avoid conflict over resources. The uncontrolled extension of irrigated agriculture in Sudan will increase the pressure on the already scarce water resources in Egypt.
The Curious Case of Baby Formula in the United States in 2022: Cries for Urgent Action Months after Silence in the Midst of Alarm Bells
Authors: Jung Jinho , Widmar Nicole Olynk , Ellison Brenna 
Published: December 2022

AbstractThe shortages of baby formula in the US resulting from the voluntary recall of contaminated products and shutdown of manufacturing facility in February led to increases in the national out-of-stock rate of the baby formula from 18 to 70% over the summer of 2022. This study utilizes social media listening and data analysis to examine how online media reactions to the physical shortage changed over time and how the reaction to the shortage differed from to the initial recall announcements. Improved understanding of reactions to emergent issues in foods through this lens may improve communication efficiency to mitigate potential consequences.
Control algorithm for a 6 kW hall thruster
Authors: Matsunaga Yoshiki , Watanabe Hiroki , Cho Shinatora , Funaki Ikkoh , Kusawake Hiroaki , Kajiwara Kazuhiro , Kurokawa Fujio , Takahashi Toru 
Published: December 2022

AbstractThis paper presents a control algorithm for ensuring the stable operation of a 6 kW Hall thruster. The Japan Aerospace Exploration Agency is developing a “wide-range” power processing unit (PPU) to power a 6 kW Hall thruster system, a candidate for all-electric satellites. The PPU provides discharge oscillation, power, and discharge current control. The increments in the control loop are fixed, so the PPU digital controller does not need to calculate them, and the algorithm’s computational complexity is minimal. Results of integration tests on the 6 kW Hall thruster and the PPU breadboard model showed that the three control functions run correctly. The total controlled PPU power was adjusted in the range of 3.45–3.55 kW under constant power control with a target of 3.5 kW. Oscillations of ± 0.05 kW around the target power are acceptable. 70% of the peaks in the discharge current acquired for 100 ms exceeded the limit of 1.5A. Discharge oscillation control varied the coil magnetic field and reduced them to 0%. The PPU successfully controlled the coil current, reducing the discharge current from 13.7 A to 13 A. The propulsion efficiency increased from 59% to 60.5%.