bluuebunny/crossref_metadata_2025_split huggingface dataset:
When Will You Succeed Casting Patients With Early-onset Scoliosis? Prospective Evaluation of Predictive Radiographic Parameters
Authors: Glotzbecker Michael P. , Du Jerry Y. , Dumaine Anne M. , Ramo Brandon A. , Kelly Derrek M. , Birch Craig M. , Sturm Peter F. ,   PSSG
Published: April 2022

Background:
In a recent retrospective study, in cast correction of the major curve correlated with final curve size in patients with early-onset scoliosis treated with casting. We therefore sought to perform a prospective study with controlled methodology to determine if there are parameters associated with reduction of coronal deformity.

Methods:
A prospective, observational study was conducted between 2014 and 2019 at selected sites willing to comply with a standard radiographic and follow-up protocol. Radiographic data was collected at time points of precast, in traction, initial in-cast, and at minimum 1 year follow-up. Multivariate linear regression models were utilized to control for potential confounders using a stepwise procedure. Twenty-nine patients met inclusion criteria.

Results:
On multivariate analysis, traction major curve (P=0.043) and initial in-cast (P=0.011) major curve Cobb angles were independently associated with final out of cast major curve Cobb angle. The only factor that was independently associated with failure to cure (<15-degree major curve) was traction major curve Cobb angle (P=0.046). A threshold traction major curve Cobb angle of 20 degrees was found to have good accuracy with 81% sensitivity and 73% specificity (receiver operator curve area: 0.869, P<0.001). A traction major curve Cobb angle over 20 degrees would accurately predict failure of casting treatment to cure scoliosis in 79% of cases. A threshold in-cast major curve Cobb angle of 21 degrees was found to have slightly less accuracy than traction with 69% sensitivity, 82% specificity, and 74% accuracy (receiver operator curve area: 0.830, P=0.004).

Conclusions:
Radiographic measurements in traction and initially in the cast are predictive of curve size at follow-up for children with early-onset scoliosis treated with casting. The standardization and utility of traction films should be further explored.

Level of Evidence:
Level II.
In-hospital and 1-Year Outcomes of Repeated Percutaneous Coronary Intervention for In-stent Restenosis With Acute Coronary Syndrome Presentation
Authors: Nozari Younes , Mojtaba Ghorashi Seyyed , Alidoust Mostafa , Hamideh Mortazavi Seyedeh , Jalali Arash , Omidi Negar , Fazeli Amir , Aghajani Hassan , Salarifar Mojtaba , Reza Amirzadegan Ali 
Published: April 2022

Background:
In-stent restenosis (ISR) is the Achilles’ heel of percutaneous coronary intervention (PCI). There have been controversial data about outcomes of repeated PCI (redo-PCI) for ISR. This study aims to determine the predictors of major adverse cardiac events (MACE) in patients underwent redo-PCI for ISR.

Methods:
In this retrospective study, all patients with acute coronary syndrome who were underwent successful PCI for ISR at Tehran Herat Center (between 2004 and 2019) were eligible for inclusion. Patients with moderate to severe valvular heart disease and/or hematological disorders were excluded. Participants were divided into 2 groups based on the occurrence of the MACE [composite of cardiovascular death, myocardial infarction (MI), coronary artery bypass grafting, target vessel revascularization, and target lesion revascularization]; then, the study variables were compared between the 2 groups. Finally, the predictors of MACE were identified using Cox regression analysis.

Results:
Of 748 redo-PCI patients (mean age: 65.2 ± 10.1; 71.0% males), 631 patients had met the inclusion criteria. Fifty-four patients (9.8%) developed MACE within a 1-year follow-up period. Multivessel disease, primary PCI, Ad-hoc PCI, history of non–ST-segment elevation MI, and diabetes mellitus were independent predictors for MACE. In a subgroup analysis, 30 patients who experienced third PCI (target lesion revascularization/target vessel revascularization) were followed more as 1-year MACE. Among these patients, 14 MACEs were observed during the last follow-up (till June 2020).

Conclusions:
Multivessel disease, primary PCI, and history of non–ST-segment elevation MI were the predictors of higher 1-year MACE, whereas Ad-hoc PCI and diabetes mellitus had a protective effect on MACE.
Exploratory Analysis of Associations Between Whole Blood Mitochondrial Gene Expression and Cancer-Related Fatigue Among Breast Cancer Survivors
Authors: Kleckner Amber S. , Kleckner Ian R. , Culakova Eva , Wojtovich Andrew P. , Klinedinst N. Jennifer , Kerns Sarah L. , Hardy Sara J. , Inglis Julia E. , Padula Gilbert D. A. , Mustian Karen M. , Janelsins Michelle C. , Dorsey Susan G. , Saligan Leorey N. , Peppone Luke J. 
Published: April 2022

Background
Cancer-related fatigue is a prevalent, debilitating, and persistent condition. Mitochondrial dysfunction is a putative contributor to cancer-related fatigue, but relationships between mitochondrial function and cancer-related fatigue are not well understood.

Objectives
We investigated the relationships between mitochondrial DNA (mtDNA) gene expression and cancer-related fatigue, as well as the effects of fish and soybean oil supplementation on these relationships.

Methods
A secondary analysis was performed on data from a randomized controlled trial of breast cancer survivors 4–36 months posttreatment with moderate–severe cancer-related fatigue. Participants were randomized to take 6 g fish oil, 6 g soybean oil, or 3 g each daily for 6 weeks. At pre- and postintervention, participants completed the Functional Assessment of Chronic Illness Therapy–Fatigue questionnaire and provided whole blood for assessment of mtDNA gene expression. The expression of 12 protein-encoding genes was reduced to a single dimension using principal component analysis for use in regression analysis. Relationships between mtDNA expression and cancer-related fatigue were assessed using linear regression.

Results
Among 68 participants, cancer-related fatigue improved and expression of all mtDNA genes decreased over 6 weeks with no effect of treatment group on either outcome. Participants with lower baseline mtDNA gene expression had greater improvements in cancer-related fatigue. No significant associations were observed between mtDNA gene expression and cancer-related fatigue at baseline or changes in mtDNA gene expression and changes in cancer-related fatigue.

Discussion
Data from this exploratory study add to the growing literature that mitochondrial dysfunction may contribute to the etiology and pathophysiology of cancer-related fatigue.
Low-Grade Oncocytic Renal Tumor With Massive Liver Metastasis: Do Not Trust a Negative CK7 and Misdiagnose Oncocytoma: A Cautionary Tale and Current Classification of Oncocytic Renal Tumors
Authors: Burke Allen , Legesse Teklu , Paulk Adina 
Published: April 2022

Abstract
We report a renal tumor originally diagnosed as oncocytoma that recurred with biopsy-proven multiple liver metastases. Review of the initial tumor revealed a predominantly CK7-negative neoplasm that had areas resembling oncocytoma, areas resembling eosinophilic chromophobe renal cell carcinoma, and areas with intermediate features. The case illustrates that the distinction between eosinophilic chromophobe renal cell carcinoma and “oncocytic tumor of uncertain malignant potential” is in some cases subjective. Criteria need better definition and should not be based on cytokeratin 7 staining pattern alone. A discussion of the current classification of oncocytic renal tumors is included, as well as a discussion of the differential diagnosis of renal neoplasms with eosinophilic cytoplasm.
Kikuchi Disease Masquerading as a T-Cell Lymphoma
Authors: Aqil Barina , Kaur Amandeep 
Published: April 2022

Abstract
Kikuchi-Fujimoto disease, also known as histiocytic necrotizing lymphadenitis, is most prevalent in Asia and has been increasingly recognized in other parts of the world. It usually occurs more frequently in females and presents as fever and localized cervical lymphadenopathy. It resolves spontaneously, usually over a period of several weeks up to 6 months. Its initial clinical features are commonly similar to that of a lymphoma, and it can be misdiagnosed both by clinicians and pathologists. Kikuchi disease has been associated with systemic lupus erythematosus. We report a case of Kikuchi disease that occurred in a 25-year-old female patient that masqueraded as a T-cell lymphoma.
Desmoplastic Small Round Cell Tumor Is an Important Mimic of High-Grade Carcinoma in Colonic Biopsy Samples
Authors: Hissong Erika , Yantiss Rhonda K. 
Published: April 2022

Abstract
Desmoplastic small round cell tumor (DSRCT) is a rare but aggressive malignancy that usually occurs within the intra-abdominal cavities of young adult males. Most DSRCTs can be reliably diagnosed based on the presence of characteristic morphology; coexpression of epithelial, myogenic, and neural markers; and detection of the reciprocal translocation t(11;22)(p13:21) associated with the EWS::WT1 fusion. However, occasional tumors lack classic features, affect older adults, or are located outside the abdominal cavity. Mucosal biopsy samples can pose challenges when both the stromal and epithelial components are not represented. Herein, we present a case of DSRCT that simulated clinical and histologic features of a colonic adenocarcinoma. Biopsy sampling revealed nests of cytokeratin-positive epithelioid cells that simulated a high-grade carcinoma with neuroendocrine features. This case report emphasizes the importance of considering this rare entity when presented with high-grade epithelioid tumors that occur in young patients.
Proteinuria in Deceased Kidney Transplant Donors for Prediction of Chronic Lesions in Pretransplant Biopsies: A Prospective Observational Study
Authors: Haupenthal Frederik , Kläger Johannes , Bauernfeind Florian , Heinzel Andreas , Doberer Konstantin , Mayer Katharina , Naar Luis , Eigenschink Michael , Hu Karin , Regele Heinz , Szekeres Thomas , Berlakovich Gabriela , Reindl-Schwaighofer Roman , Bond Gregor 
Published: April 2022

Background.
Pretransplant kidney graft biopsies have been suggested for organ quality assessment. Data on the association between donor proteinuria and organ quality of deceased donors are not available.

Methods.
In this prospective study, we analyzed 147 pretransplant kidney biopsies from 88 deceased adult donors procured and transplanted consecutively at the Medical University Vienna between July 2017 and May 2020. Lesions in each renal compartment were scored from 0 to 5 with each ascending score representing a 20% increase in organ damage. A chronic lesions score was calculated including glomerulosclerosis, intima fibrosis, hyalinosis, interstitial fibrosis, and tubular atrophy.

Results.
The median chronic lesion score was 2 (interquartile range [IQR] 1–4) and the median donor urinary protein to creatinine ratio (UPCR) was 382 mg/dL (IQR 222–703). There was a positive correlation between UPCR and number of chronic lesions (β 0.15, 95% confidence interval, 0.03-0.28; P = 0.019). Biopsies with 2 or more lesions had a median UPCR of 486 mg/dL (IQR 251–717) compared with 274 mg/dL (IQR 211–556; P = 0.016) in biopsies with <2 lesions. The risk for detection of 2 or more lesions rose by 18% for every log increase in UPCR (risk ratio 1.18, 95% confidence interval, 1.03-1.25; P = 0.017). Multivariable and sensitivity analysis revealed an independent and robust association between chronic lesions and UPCR.

Conclusions.
Donor UPCR is associated with chronic lesions in pretransplant deceased donor kidney graft biopsies. This finding justifies further investigation of donor proteinuria for the assessment of organ quality and outcome.
Reducing fatigue-related symptoms in Long COVID-19: a preliminary report of a lymphatic drainage intervention
Authors: H. Heald Adrian , Perrin Raymond , Walther Andreas , Stedman Mike , Hann Mark , Mukherjee Annice , Riste Lisa 
Published: April 2022

Introduction
In the early days of the first global wave of the COVID-19 pandemic, the potential for a postviral syndrome to manifest following COVID-19 infection was first recognized. Here, we present an analysis of a case series of the first 20 patients’ data collected in clinical practice to evaluate the potential of a possible alternative treatment for Long COVID.

Methods
Face-to-face treatment sessions with Perrin techniqueTM practitioners occurred weekly involving effleurage/other manual articulatory techniques. The individuals being treated also undertook daily self-massage along with gentle mobility exercises. Patients recorded symptom severity using the self-report 54-item profile of fatigue-related states (PFRS) before and after treatment.

Results
The mean age of male patients was 41.8 years (range, 29–53 years), and for female patients, 39.3 years (range, 28–50 years). None of the participants had a prior diagnosis of chronic fatigue syndrome, and all were new attendees to the clinics at the time of initial assessment. The average number of treatment sessions was 9.7 in men and 9.4 in women. The reduction in PFRS scores was 41.8% in men and 60.5% in women. The highest subscale scores on average were for fatigue, with the lowest for somatic symptoms. All subscale scores showed, on average, a similar reduction of approximately 50% postintervention, with the reduction in score relating to a decrease in the severity of symptoms.

Conclusion
Our findings suggest that a specific manual lymphatic drainage intervention may help to reduce fatigue symptoms related to Long COVID, perhaps preventing acute symptoms through early intervention.
Naltrexone alters cardiovascular function following acute forced swimming in mice
Authors: Longoria Candace R. , Qadiri Qudratullah S. , Matthews Evan L. , Campbell Sara C. , Guers John J. 
Published: April 2022

Purpose
Naltrexone (NTX) is an opioid antagonist that can reverse the physiological effects of opioid receptors when bound. Opioid receptors have been found to play a role in cardiovascular (CV) function, and thus, binding of NTX may alter CV activity at rest and in response to acute and chronic exercise (EX). We hypothesized that opioid receptor blockade will alter the typical CV responses following acute EX.

Methods
We assessed the effects of opioid receptor blockade on CV function via echocardiography in mice following an acute bout of forced swimming (FSw), a model of rodent EX. We administered opioid receptor antagonist, NTX, or saline in mice before FSw and in the absence of an FSw perturbation. Furthermore, we assessed how NTX can influence maximal EX capacity on a rodent treadmill.

Results
Our data shows that NTX administration does not decrease maximal EX capacity in mice (P > 0.05). However, NTX attenuated cardiac output following FSw (FSw = 52.5 ± 2.5 ml/min vs. FSw + NTX = 32.7 ± 5.2 ml/min; P < 0.05) when compared with saline control (33.5 ± 3.8 ml/min). Further, the administration of NTX in the non-EX condition significantly (P < 0.05) reduced ejection fraction.

Conclusion
These data suggest that normal opioid receptor activation is necessary for typical CV function following FSw.
Transverse spectral instability in generalized Kadomtsev–Petviashvili equation
Authors: Bhavna  , Kumar Atul , Pandey Ashish Kumar 
Published: April 2022

We study transverse stability and instability of one-dimensional small-amplitude periodic travelling waves of a generalized Kadomtsev–Petviashvili equation with respect to two-dimensional perturbations, which are either periodic or square-integrable in the direction of the propagation of the underlying one-dimensional wave and periodic in the transverse direction. We obtain transverse instability results in KP-fKdV, KP-ILW and KP-Whitham equations. Moreover, assuming the spectral stability of one-dimensional wave with respect to one-dimensional square-integrable periodic perturbations, we obtain transverse stability results in the aforementioned equations.
Erwinia phyllosphaerae sp. nov., a novel bacterium isolated from phyllosphere of pomelo (Citrus maxima)
Authors: Pan Ming-Kai , Feng Guang-Da , Yao Qing , Li Jiali , Liu Chenjian , Zhu Honghui 
Published: April 2022

A novel phosphate-solubilizing and 3-indoleacetic acid producing bacterium, designated strain CMYE1T, was isolated from the phyllosphere of pomelo (Citrus maxima) in Meizhou, Guangdong Province, PR China. Cells were Gram-stain-negative, facultative aerobic, non-spore-forming, rod-shaped and motile with peritrichous flagella. It had the highest 16S rRNA gene sequence similarity to

Kalamiella piersonii

NRRL B-65522T (99.0 %), followed by

Pantoea cypripedii

LMG 2657T (98.1 %),

Erwinia iniecta

B120T (97.7 %),

Mixta intestinalis

29Y89BT (97.6 %) and other species (<97.6 %). However, phylogenomic analyses clearly showed that strain CMYE1T should be assigned into the genus

Erwinia

, and was most closely related to

Erwinia oleae

LMG 25322T (96.7 %). Genome comparisons showed that the novel strain shared ≤83.2 % average nucleotide identity and ≤26.5 % digital DNA–DNA hybridization values with closely related strains, respectively. It contained C16 : 0, C17 : 0 cyclo, summed feature 3 (C16 : 1
ω7c and/or C16 : 1
ω6c) and summed feature 8 (C18 : 1
ω7c and/or C18 : 1
ω6c) as the major fatty acids. Based on the results of phylogenetic, phenotypic and chemotaxonomic analyses, as well as genome comparisons, strain CMYE1T belongs to a novel species of the genus

Erwinia

, for which the name Erwinia phyllosphaerae sp. nov. is proposed with the type strain CMYE1T (=GDMCC 1.2674T=JCM 34792T).
SIGNIFICANT IMPROVEMENT IN MELANOMA SURVIVAL OVER THE LAST DECADE: A HUNGARIAN NATIONWIDE STUDY BETWEEN 2011–2019
Authors: Liszkay Gabriella , Benedek Angela , Polgár Csaba , Oláh Judit , Holló Péter , Emri Gabriella , Csejtei András , Kenessey István , Polányi Zoltán , Knollmajer Kata , Várnai Máté , Vokó Zoltán , Nagy Balázs , Rokszin György , Fábián Ibolya , Barcza Zsófia , Gyulai Rolland , Kiss Zoltan 
Published: April 2022

ABSTRACTBackgroundRecent real-world studies have reported significant improvements in the survival of malignant melanoma in the past few years, mainly as a result of modern therapies. However, long-term survival data from Central Eastern European countries such as Hungary are currently lacking.MethodsThis nationwide, retrospective study examined melanoma survival in Hungary between 2011–2019 using the databases of the National Health Insurance Fund (NHIF) and Central Statistical Office (CSO) of Hungary. Crude overall survival and age-standardized 5-year net survival as well as the association between age, sex, and survival were calculated.ResultsBetween 2011 and 2019, 22,948 newly diagnosed malignant melanoma cases were recorded in the NHIF database (47.89% male, mean age: 60.75 years (SD: ±16.39)). 5-year overall survival was 75.40% (women: 80.78%; men: 69.52%). Patients diagnosed between 2017–2019 had a 20% lower risk of mortality compared to patients diagnosed between 2011–2012 (HR 0.80, 95% CI 0.73–0.89; p<0.0001). Age-standardized 5-year net survival rates in 2011–2014 and 2015–2019 were 90.6% and 95.8%, respectively (women: 93.1% and 98.4%, men: 87.8% and 92.7%, respectively). The highest age-standardized 5-year net survival rates were found in the 0–39 age cohort (94.6% in the 2015-2019 period).ConclusionHungary has similar melanoma survival rates to Western European countries. Based on net survival, the risk of dying of melanoma within 5 years was cut by more than half (55%) during the study period, which coincides with the successful implementation of awareness campaigns and the wide availability of modern therapies.
Determinants of facility-based childbirth among adolescents and young women in Guinea: a secondary analysis of the 2018 Demographic and Health Survey
Authors: Grovogui Fassou Mathias , Benova Lenka , Manet Hawa , Sidibe Sidikiba , Dioubate Nafissatou , Camara Bienvenu Salim , Beavogui Abdoul Habib , Delamou Alexandre 
Published: April 2022

IntroductionMaternal mortality remains very high in Sub-Saharan African countries and the risk is higher among adolescent girls. Maternal mortality occurs in these settings mainly around the time of childbirth and the first 24 hours after birth. Therefore, skilled attendance in an enabling environment is essential to reduce the occurrence of adverse outcomes for both women and their children. This study aims to analyze the determinants of facility childbirth among adolescents and young women in Guinea.MethodsWe used the Guinea Demographic and Health Survey (DHS) conducted in 2018. All females who were adolescents (15 -19) or young women (20-24 years) at the time of their most recent live birth in the five years before the survey were included. We examined the use of health facilities for childbirth and its determinants using multivariable logistic regression, built through the Andersen health-seeking model.ResultsOverall, 58% of adolescents and 57% of young women gave birth in a health facility. Young women were more likely to have used private sector facilities compared to adolescents (p<0.001). Factors significantly associated with a facility birth in multivariable regression included: secondary or higher educational level (aOR=1.81; 95%CI:1.20-2.64) compared to no formal education; receipt of 1-3 antenatal visits (aOR=8.93; 95%CI: 5.10-15.55) and 4+ visits (aOR=15.1; 95%CI: 8.50-26.84) compared to none; living in urban (aOR=2.13; 95%CI: 1.40-3.37) compared to rural areas. Women from poorest households were least likely to give birth in health facilities. There was substantial variation in the likelihood of birth in a health facility by region, with highest odds in NZérékoré and lowest in Labé.ConclusionThe percentage of births in health facilities among adolescents and young women in Guinea increased since 2012 but remains suboptimal. Socio-economic characteristics, region of residence and antenatal care use were the main determinants of its use. Efforts to improve maternal health among this group should target care discontinuation between antenatal care and childbirth (primarily by removing financial barriers) and increasing the demand for facility-based childbirth services in communities, while paying attention to the quality and respectful nature of healthcare services provided there.