bluuebunny/crossref_metadata_2025_split huggingface dataset:
Lead Data Mapping to Prioritize US Locations for Whole-of-Government Exposure Prevention Efforts: State of the Science, Federal Collaborations, and Remaining Challenges
Authors: Zartarian Valerie , Poulakos Antonios , Garrison Veronica Helms , Spalt Nicholas , Tornero-Velez Rogelio , Xue Jianping , Egan Kathryn , Courtney Joseph 
Published: September 2022

For this state-of-science overview of geospatial approaches for identifying US communities with high lead-exposure risk, we compiled and summarized public data and national maps of lead indices and models, environmental lead indicators, and children’s blood lead surveillance data.Currently available indices and models are primarily constructed from housing-age and sociodemographic data; differing methods, variables, data, weighting schemes, and geographic scales yield maps with different exposure risk profiles. Environmental lead indicators are available (e.g., air, drinking water, dust, soil) at different spatial scales, but key gaps remain. Blood lead level data have limitations as testing, reporting, and completeness vary across states.Mapping tools and approaches developed by federal agencies and other groups for different purposes present an opportunity for greater collaboration. Maps, data visualization tools, and analyses that synthesize available geospatial efforts can be evaluated and improved with local knowledge and blood lead data to refine identification of high-risk locations for prioritizing prevention efforts and targeting risk-reduction strategies. Remaining challenges are discussed along with a work-in-progress systematic approach for cross-agency data integration, toward advancing “whole-of-government” public health protection from lead exposures. (Am J Public Health. 2022;112(S7):S658–S669. https://doi.org/10.2105/AJPH.2022.307051 )
Application of Financial Reports on Frozen Food SMEs Using Linear Sequential
Authors: Dhani Muhammad Arsyad , Indahyanti Uce 
Published: October 2022

Planning in managing finances is needed by SMEs in order to be able to overcome a financial problem in everyday life. The existence of a financial report application no longer records in a book or paperless without the need to flip through the financial report book again to take notes. This financial report application provides a better overview and control of financial management, income, and life in general financially and provides information and meets the needs of financial management in SMEs in their operational activities. This study uses the method of a linear sequential development model, an approach to systematic and sequential software development that starts at the system level and progresses through analysis, design, coding, testing, and maintenance. As a result, web-based financial report applications can make it easier to provide information to the finance department. The financial report application works well in searching for money recording data and also in presenting information easily. Facilitates the process of processing financial records and making financial reports. The application is made web, so that in running this application the user requires a web browser.
Genome resequencing facilitates high resolution exploration of a maize quantitative trait locus for resistance to aflatoxin accumulation
Authors: Shan Xueyan , Williams W. Paul , Peterson Daniel G. 
Published: September 2022

Abstract

Aflatoxin contamination is a major threat to maize production in the Southeastern United States. Screening for genetic resistance to aflatoxin has led to the identification of aflatoxin-resistance quantitative trait loci (QTL) in maize inbred lines. However, these QTLs typically span large DNA regions making identification of actual resistance-associated sequences difficult. In this study, we took the portion of the maize B73 genome at chromosome bin 4.06 (APG v3) containing a 22 Mbp QTL (QTL-4.06) associated with aflatoxin resistance and used it as a reference to identify single-nucleotide polymorphisms (SNPs) and insertion/deletion variants (INDELs) that differ between resistant (Mp313E and Mp715) and susceptible (B73 and Va35) maize inbred lines. Our study provides a rich list of SNPs and INDELs that can be used as markers in fine-mapping of candidate regions in QTL-4.06 and demonstrates the great potential of resequencing in generating higher density molecular maps that can be leveraged in molecular breeding-based crop improvement.
Detection of spontaneous neutral kaons K0L and K0s from ultra-dense hydrogen H(0)
Authors: Holmlid Leif , Kotzias Bernhard 
Published: September 2022

Abstract
We here report muon and gamma photon signatures from decay of neutral kaons K0L and K0sto complement the published results of kaon generation from laser-induced baryon annihilation in H(0) (Holmlid and Olafsson, High Energy Density Physics 2021, and Holmlid, International Journal of Hydrogen Energy 2021). One well-known complication in the kaon detection is the oscillation process between the neutral kaons K0L and K0s caused by interaction with matter. Particle energy measurements with plastic scintillators identify one process which generates two muons simultaneously from one mode of decay of . Particle energy measurements with Al converters (without scintillator) in the separated, enclosed charged particle detector identify further modes of decay of K0L and K0s, all producing a few simultaneous high-energy gamma photon peaks in the approximate energy range 20 - 100 MeV. Neutral kaons are observed only when ultradense hydrogen H(0) is deposited in the meson generator. The results presented are mainly from spontaneous reactions in H(0). The experimental setup uses an enclosed PMT with Al foil converter and a multichannel analyzer (MCA) for pulse energy analysis. Using this method the radiation damage from neutral kaons can be investigated. Due to the low cross section of the neutral kaons in interaction with matter there exists no other method to identify them with certainty outside large physics laboratories.
Vagus Nerve Stimulation Modulates Inflammation in Treatment-resistant Depression Patients
Authors: Lespérance Paul , Desbeaumes-Jodoin Véronique , Drouin David , Racicot Frédéric , Miron Jean-Philippe , Longpré-Poirier Christophe , Fournier-Gosselin Marie-Pierre , Thebault Pamela , Lapointe Réjean , Arbour Nathalie , Cailhier Jean-François 
Published: September 2022

Abstract
Background
The role of inflammation in major depression is increasingly recognized. Vagal neurostimulation (VNS) is used for the treatment of epilepsy and major medical-refractory depression. VNS has neuropsychiatric functions and systemic anti-inflammatory activity. The objective of this study is to measure the clinical efficacy and assess the impact on the modulation of VNS in depressive patients.
Materials and Methods
Six patients with refractory depression were enrolled. Depression symptoms were assessed with the Montgomery-Asberg Depression Rating, and anxiety symptoms with the Hamilton Anxiety Rating Scale Scale at baseline, 12 and 24 months and also at the time of post-implantation blood harvest. To assess modulation of inflammation, plasmas were harvested prospectively before implantation of VNS (baseline) and up to after four years or more of continuous therapy. 40 soluble molecules were measured in the plasma by multiplex assays. Data were analyzed using descriptive statistics and repeated measures multivariate ANOVAs were performed.
Results
At time of latter blood harvest, reduction of the mean depression severity score was 59,9% and response rate was 87%. Anxiety levels were also greatly reduced. We observed a modulation of several cytokines and inflammatory proteins in TRD patients after more than 4 years of continuous therapy. IL-7, CXCL8, CCL2, CCL13, CCL17, CCL22, Fms-like tyrosine kinase-1 (Flt-1) and Vascular endothelial growth factor-C (VEGF) levels were significantly lowered, whereas levels of basic Fibroblast growth factor (bFGF) were increased (p values ranging from 0.004 to 0.02).
Conclusions
This exploratory study is the first to focus on long term efficacy of VNS and its consequences on inflammation biomarkers. VNS was associated with a significant and sustained clinical response in patients with major refractory depression patients. Our results suggest that VNS may modulate inflammation via an increase in the blood-brain barrier integrity and a reduction in inflammatory cells recruitment. This opens the door to new pathways involved in the treatment of refractory depression.
The association between alcohol intake and obesity in a sample of the Irish adult population
Authors: Alkalbani Salma 
Published: September 2022

Abstract

Background: The prevalence of obesity is increasing worldwide. Alcohol has been studied as a possible risk factor for obesity, but the evidence is discordant. This study examined the association between alcohol consumption and obesity in an Irish population.
Method: A cross-sectional study using secondary data from the Healthy Ireland Survey 2017 was conducted. Descriptive and comparative data were analysed to identify associations of alcohol-related variables with waist circumference (WC) and body mass index (BMI). Regression analysis was performed to examine the associations between harmful alcohol consumption (AUDIT-C score≥ 5) and obesity indicators. Adjustments were made for sociodemographic variables, health-related variables, and other alcohol-related variables.
Result: A total of 7486 participants took part in this survey (response rate=60.4%). Most of the participants (86.5%) were alcohol drinkers, with the majority drinking less than 3 times per week (77.5%); 49.1% were considered harmful drinkers. After controlling for possible confounders, positive associations of harmful alcohol consumption with WC (β=1.98, 95% CI: 1.00, 2.96) and BMI (OR=1.25, 95% CI: 1.06, 1.47) were observed. Further controlling for alcohol consumption frequency and binge drinking made this association nonsignificant. Unlike less frequent binge drinking, frequent binge drinking was positively associated with WC (β=2.03, 95% CI: 0.89, 3.17).
Conclusion: Harmful alcohol consumption was associated with obesity (high BMI, large WC) after controlling for possible confounders; however, this association became nonsignificant after controlling for other alcohol-related variables. Frequent binge drinkers were more likely to have a large WC. Further longitudinal studies to examine the exact association between alcohol consumption and obesity are warranted.
Geochemical and cosmogenic tracers to define the aquifer’s vulnerability: the case study of the alluvial multi- aquifer system of the Friulian plain
Authors: Renzo Dino Di , Rizzo Antonietta , Telloli Chiara , Salvi Stefano , Marrocchino Elena , Nieto Daniel , Vaccaro Carmela 
Published: September 2022

Abstract

The Friuli-Venezia Giulia Region (north of Italy) is characterized by the presence of high-quality freshwater resources which benefit local citizens, animals, and environmental habitats and also agriculture and production activities. In collaboration with the LTA consortium “Livenza Tagliamento Acque”, ENEA and the University of Ferrara, different kinds of waters from wells selected in the Fiume Veneto area were sampled and analysed to characterize them from a geochemical point of view. The results obtained made it possible to support the plans for the protection of water reserves formed by the multi-aquifer system of the high and medium Friuli plain, following the legislation of the water directive. It was also possible to define a circular and sustainable plan for the use of surface water resources respecting the natural recharge balances of aquifers, and the minimum flow of rivers and canals, taking into account the overexploitation due to unauthorized withdrawals. This study based on isotopic geochemistry makes available the estimation of the relationships between recharge capacity and water use of the Fiume Vento area in the Friuli Venezia Giulia region. This methodology allows defining the average age of the resources based on the time required for the recharge contributions to compensate for the losses induced by exploitation and resurgence.
Time Series Modeling of Road Traffic Crashes in Himalayan States of India
Authors: Yadav Bibek , Hossain Moazzem 
Published: September 2022

Abstract

Road Traffic Accidents in India are increasing at a high rate due to the large percentage of slow-moving vehicles and in absence of proper traffic management systems. In hilly regions, the road accident scenario is further gloomy due to narrow roads, steep slopes, hairpin bends, presence of a valley or river on one side of the roads. In a hilly location, there are various elements that contribute to accidents, and it's important to understand how these factors interact. Road crash time forecasting was done for accidents that happened over a three-year period. Auto-regressive Integrated Moving Averages (ARIMA) models were applied to the collected data and an 84-month forecast was based made based on the fitted models. Based on the results of this study, the rate of road accidents is expected to decrease in Nagaland and Meghalaya while increases in Sikkim and Manipur constant for at least the next seven years. It was found that the incidence of road accidents in Nagaland, Manipur, Meghalaya, Sikkim, and Jammu &Kashmir can be fitted ARIMA (0,1,1) (1,1,0) [12], ARIMA (0,1,1) (0,1,0) [12], ARIMA (0,1,1) (0,1,0) [12], ARIMA (0,1,1) (0,1,0) [12] and (0,1,1) (0,1,0) [12] respectively. Remedial measures are suggested for the implementation of improved better policies and close monitoring of road traffic systems. This study provides information that could be useful for determining road accident rates in those states and would be used for providing important information to extend awareness concerning road safety.
White Light Emissive Vitrimers for Phosphor-free Light Emitting Diode Encapsulations
Authors: Gao Hong , Wang Miaomiao , Mao Yifan , Wang Zhen , Zhang Cheng , Jing Lin , Xia Youyi , Li Weijin , Zhang Kui , Zeng Haibo 
Published: September 2022

Abstract
Current encapsulating materials for white light–emitting diodes (WLEDs) have some insurmountable problems of unrecyclable encapsulating materials and the toxicity of phosphors. The much more promising encapsulating materials should have two characteristics: 1) the chip can be directly encapsulated without phosphors via the luminescence of encapsulating materials, and 2) the encapsulating materials can be reprocessed for recycling. To this end, blue-light emissive vitrimers (BEVs) were first prepared from the reaction of epoxy resin with aliphatic amines, which exhibited strong blue-light emission at 365-nm excitation and fast stress relaxation without an external catalyst. To design the white-light emission, a well-designed yellow element of perylenetetracarboxylic dianhydride was grafted into the BEVs to generate white-light emissive vitrimers (WEVs). In the WEVs, a rare combination of blue- and yellow-light emissions was achieved for designing white light. When the WEV was used as an encapsulating adhesive for 365-nm LED chips without phosphors, stable white light with CIE coordination (0.30, 0.32) was successfully achieved, which provided a promising future for WLED encapsulations.
Identification of IFIT3 as potential biomarker in Psoriasis based on integrated bioinformatics analysis
Authors: Zhang Runtian , Chen Guangshan , Chen Xi , Duan Xingwu , Bai Chunxiao , Gao Yuexuan , Qu Tiange 
Published: September 2022

Abstract
Background: To explore the function and related signal pathway of IFIT3 gene in skin lesions of patients with psoriasis by bioinformatics methods, and to find the potential specific molecular markers of psoriasis.
Methods: The limma R package was used to analyze the three data sets of GSE13355, GSE30999 and GSE106992 from the GEO (Gene Expression Omnibus) and the differential genes were screened. The STRING database was used for GO (Gene ontology) enrichment analysis, KEGG (Kyoto encyclopedia of genes and genomes) pathway analysis and protein-protein interaction (PPI) network integration. After that, the IFIT3 subnetwork was extracted and analyzed by GSEA (gene set enrichment analysis) using Metascape database and the effectiveness of gene differentiation and disease tissue identification was verified.
Results: In the study, 426 differential genes were obtained, of which 322 were significantly up-regulated and 104 were significantly down-regulated. GO enrichment analysis showed that differential genes were mainly involved in the process of immunity and metabolism, KEGG pathway enrichment analysis mainly included chemokine signal pathway, PPAR signal pathway, IL-17 signal pathway and so on. According to the analysis of IFIT3 subnetwork, it was found that IFIT3 was mainly involved in the biological processes of viruses, bacteria and other microorganisms. The pathways obtained by GESA were mainly related to immune, metabolic and antiviral pathways. IFIT3 was highly expressed in psoriatic lesions and it may be helpful in the diagnosis of psoriasis.
Conclusion: The differential genes, biological processes and signal pathways of psoriasis, especially the related information and diagnostic efficiency of IFIT3 gene, were obtained by bioinformatics analysis. These results may provide theoretical basis and new direction for exploring the pathogenesis of psoriasis, finding diagnostic markers and developing drug treatment targets.
Colonization and antagonistic activity of endophytic fungi in seagrasses: understanding endophyte interactions
Authors: Kinamot Venus , Monotilla Alvin 
Published: September 2022

Abstract
Endophytic fungal colonization in plants is governed by complex interactions with the defense mechanism of the host and antagonistic effects of other endophytes. In this study, endophytic fungal interaction was assessed by histological examination and co-culture methods. Results showed fungal colonization in the intercellular space of the epidermis and both intercellular and intracellular spaces of the cortical cells suggesting close interaction with their seagrass hosts. Dense colonization, hyphal branching, coiling and formation of networks were observed in the cortical cells. Less competition for space and reliable source of nutrition in the cortex may favor fungal growth. No fungal hyphae were detected in the vascular tissues of seagrasses. All the endophytic fungi isolated from seagrasses showed antagonistic activity. Aspergillus tamarii, A. ochraceopetaliformis, Penicillium citrinum, Beauveria bassiana, Eutypella sp. and Xylaria sp were the most active antagonists. Antagonistic interaction involved deadlock and replacement. Deadlock was associated with physical blocking of the antagonist’s colony by hyphal aggregation and production of inhibitory metabolites. Demarcation line and colony pigmentation in Xylaria sp. during co-culture assay indicated the production of high quantities of inhibitory molecules. Endophytic fungi in seagrasses also produced volatile organic compounds (VOC) which resulted to deadlock at mycelial distance. Thus, endophyte colonization and distribution in seagrass tissues are influenced by their interaction with the hosts and other endophytes. But interestingly, cyclical intransitivity of multispecies interaction manifested by these fungal species suggested possible co-existence in seagrass tissues.
Brain Activity Underlying Visual Search in Depth when Viewing Volumetric Multiplanar Images
Authors: Naderi Mehrdad , Pladere Tatjana , Krumina Gunta , Alksnis Reinis 
Published: September 2022

Abstract
By developing several different methods to present 3-dimensional (3D) images, a demand to investigate the interaction with the human visual system is inevitable. Although current estimates centered on stereoscopic depth perception, still our knowledge is low about the effect of non-stereoscopic displays on the visual cortex, both at the sensory and cognitive brain reactions. In this study, we investigated the cortical activity correlated with a volumetric multiplanar image perception in both 3D and 2D by analyzing the event-related potentials (ERPs) and Power Spectral Density (PSD) analysis. The study was designed based on two conditions. The first condition (3D test) was arranged by presenting four constant angular size rings in which one of them was closer to the subjects. The second condition (2D test) was done by adding trials with the same ring features while all rings were presented on the same plane. A volumetric multiplanar display was employed to present the non-stereoscopic visual targets. Moreover, the brain signal was recorded via an EEG amplifier and then analyzed by the EEGLAB toolbox on MATLAB. Event-related potentials (ERPs) studied in three time windows, (50-100ms), (100-200ms), and (200-450ms), correspond with the N1, P2, and P3 components of ERPs. The analysis showed no significant differences in amplitude between two conditions across five occipital and parietal electrodes, even though there was only a significant difference in latency of the P3 component on the Pz electrode. Furthermore, the Power Spectral Density (PSD) of the alpha and the beta oscillation was analyzed. The analysis does not show significant differences between 3D and 2D tasks; nevertheless, slightly higher alpha and beta activities seemed in 2D visualization. To conclude, 3D image representation on the volumetric multiplanar display has no more sensory or cognitive load on the human brain that responded equally to both visual conditions with a slight difference in latency of the P3 component. Moreover, depth perception on a multiplanar display requires less brain activity.
Decomposition of Changes in Malaria Status among Children under Five years: A case of Uganda and Kenya
Authors: Namawejje Hellen , Kato Richard , Atuhaire Leonard 
Published: September 2022

Abstract

This study decomposed the changes in malaria status among children under five years of Uganda and Kenya. The study used secondary data drawn from the Uganda Malaria Indicator Survey 2014–2015 and Kenya Malaria Indicator Survey 2015. A nonlinear multivariate decomposition logit regression model was used to allow the breakdown of differences in malaria status in children under the age of five years old between Uganda and Kenya into those due to differences in observable characteristics (endowments) and those due to different effects of these characteristics (coefficients). The overall difference in characteristics of children below the age of five years old contributed 31.07% of the differences in malaria status between Uganda and Kenya. In addition, the category of residence of a child under the age of five years old contributed 20% to the overall malaria Status in children under the age of five years old between the two countries. The study recommends that children under the age of five years are among the most vulnerable to malaria infection as they have not yet developed any immunity to the disease. The government of Uganda and Kenya should widely encourage children in this age bracket to sleep under long-lasting insecticidal nets and they should put in place, prompt diagnosis and effective treatment of malaria infections in all health facilities country-wide.