bluuebunny/crossref_metadata_2025_split huggingface dataset:
Knowledge, attitudes, and practices among Indonesian urban communities regarding HPV infection, cervical cancer, and HPV vaccination
Authors: Winarto Hariyono , Habiburrahman Muhammad , Dorothea Maya , Wijaya Andrew , Nuryanto Kartiwa Hadi , Kusuma Fitriyadi , Utami Tofan Widya , Anggraeni Tricia Dewi 
Published: May 2022

Background
Few studies explored Indonesian understanding of cervical cancer (CC) and the human papillomavirus (HPV) vaccination. We aimed to investigate the association between knowledge, attitudes, and practices (KAP) and socio-demographical influences related to HPV, CC, and vaccination among Indonesian urban citizens.

Methods
We conducted an online survey during March 2020-August 2021 using the Snowball sampling technique. The socio-demographic characteristic and KAP responses were collected via Google Forms from 400 respondents in Jakarta. The knowledge and attitudes were divided into HPV and CC (aspect 1) and HPV vaccination (aspect 2). Correlation between KAP scores was performed using Spearman’s test, and multiple logistic regression analyses were conducted to determine KAP predictors.

Results
Indonesian urban citizens in Jakarta were found to have poor knowledge in individual aspects of the inquiry but moderate knowledge overall, good attitude in inquiry both in each aspect and overall, and unsatisfying practices. Overall, in the general population, men, and women respectively: 50.8%, 32.4%, and 53.6% had good knowledge; 82.0%, 75.2%, and 84.4% expressed positive attitude; and 30.3%, 15.2%, and 35.6% applied favorable practice regarding questions inquired. Knowledge was weakly correlated towards attitude (ρ = 0.385) but moderately correlated with practice (ρ = 0.485); attitude was moderately correlated with practice (ρ = 0.577), all results: p<0.001. Significant odds ratio (OR) for predictors to good knowledge were female sex (OR = 2.99), higher education (OR = 2.91), and higher mother’s education (OR = 2.15). Factors related to positive attitudes were higher mother’s education (OR = 4.13), younger age (OR = 1.86), and better results in the knowledge inquiries (OR = 2.96). Factors that suggested better practices were female sex (OR = 2.33), being employed (OR = 1.68), excellent knowledge scores (OR = 4.56), and positive attitudes expressions (OR = 8.05). Having done one vaccination dose and intention to receive vaccines were significantly influenced by good KAP.

Conclusions
KAP had inter-association to successful CC and HPV prevention programs, and socio-demographical characteristics are critical to influencing better KAP.
Hidden heterogeneity: Uncovering patterns of adherence in microbicide trials for HIV prevention
Authors: Miller Lori , Prieto Merino David , Baisley Kathy , Hayes Richard 
Published: May 2022

Background
Interpretation of clinical trial results testing vaginal microbicide gels for HIV prevention depends on participant adherence. Prior to the era of antiretrovirals, microbicide trials collected adherence data via self-report, and trials typically reported trial population adherence as overall averages in primary results manuscripts. This study first sought to determine if different patterns of adherence from three trials of vaginal microbicide gels could be identified, using self-reported data and if so, how those patterns compare across trials. The second objective was to explore which individual-level factors were associated with different adherence patterns.

Methods
Data from the following three clinical trials of vaginal microbicides were used for this study: HIV Prevention Trials Network (HPTN) 035 testing PRO 2000 and Buffergel, the Microbicides Development Programme (MDP) 301 testing PRO 2000, and the Population Council’s Carraguard study, testing Carraguard gel. Latent Class Analysis (LCA) was used to identify longitudinal patterns of adherence using self-reported data about gel use. Multinomial multivariable logistic regression was used to estimate relative risk-ratios for factors which were independently associated with different latent adherence trajectories within each trial, and compared across trials.

Results
Included in this analysis are 2,282 women from HPTN 035 (age 17–56 years), 6238 women from MDP 301 (age 16–75 years), and 6039 women from Carraguard (age 16–73 years). Using LCA, 3–4 different patterns of gel adherence were identified in each trial; these patterns were similar across the trials. Factors associated with adherence patterns were identified in all trials. Older age was associated with the adherence trajectory that consistently reported gel use in three trials. Participant-reported negative reaction of partners to the gel was associated with trajectories that reported less consistent adherence in two trials. A greater number of baseline-reported sex partners or sex acts was associated with trajectories which reported less consistent adherence in some trials. Trial site location was associated with membership of trajectories in all trials.

Conclusion
LCA was able to identify patterns of microbicide gel adherence in clinical trials that used self-reported data. Key factors associated with patterns of adherence in this study were participant age, clinical trial site location, and partner reaction to the study gel. These findings, in particular, age and perceived partner reaction to the method, are consistent with results from other clinical trials and programmatic rollout of biomedical HIV prevention methods for women in Africa. This study contributes to the body of evidence that women need more support to navigate power dynamics within their relationships with men so that they can successfully use HIV prevention methods.
Effect of health facility linkage with community using postnatal card on postnatal home visit coverage and newborn care practices in rural Ethiopia: A controlled quasi-experimental study design
Authors: Tesfau Yemane Berhane , Gebrehiwot Tesfay Gebregzabher , Godefay Hagos , Kahsay Alemayehu Bayray 
Published: May 2022

Background
Postnatal home visit has the potential to improve maternal and newborn health, but it remains as a missed opportunity in many low-and middle-income countries. This study examines the effect of health extension worker administered postnatal card combined with health facility strengthening intervention on postnatal home visit coverage, newborn care practices, and knowledge of newborn danger signs in rural Ethiopia.

Methods
We employed quasi-experimental design using controlled before-and-after study in intervention and comparison districts of rural Tigray, northern Ethiopia. Training of health extension workers (HEWs) on postnatal home visit (PNHV), training of healthcare providers on maternal and newborn care, and capacity building of healthcare authorities on leadership, management and governance together with health system strengthening were the implemented interventions. Baseline (n = 705) and end line (n = 980) data were collected from mothers who delivered a year before the commencement of the actual data collection in the respective surveys. We used difference-in-differences (DiD) analysis to assess the effect of the intervention on PNHV coverage, essential newborn care practices and maternal knowledge of newborn danger signs.

Results
A total of 1685 (100%) mothers participated in this study. In all districts, more than 1/3rd of the mothers 633(37.57%) were in the age of 30–39 years. The difference-in-differences estimator showed an average of 23.5% increase in coverage of PNHVs within three days (DiD, p<0.001) and the provision of most postnatal contents significantly increased in the intervention district in the end line survey. The knowledge of at least three danger signs increased by 13.6% (p = 0.012).The DiD estimator showed an average of 27.6% increase to check the mothers for heavy bleeding (DiD, p = 0.011). This study also revealed that the checking of maternal blood pressure increased from 5.8% to 11.8% in the comparison districts and from 9.4% to 93.3% in the intervention district. The difference-in-differences estimator result showed a 9% difference in clean cord care practices among the participants (p = 0.025), 12.2% in skin to skin care (p = 0.022), and borderline significant increase in early initiation of breastfeeding (10.5%, p = 0.051).

Conclusion
We conclude that the intervention package was effective in improving the coverage of PNHV, increase in knowledge of newborn danger sign and essential newborn care practices. Hence, further strengthening the linkages between health facilities and community is imperative to improve the coverage of essential lifesaving maternal and newborn care services by HEWs at home.
Exposure factors associated with SARS-CoV-2 seroprevalence during the first eight months of the COVID-19 pandemic in the Netherlands: A cross-sectional study
Authors: Pagen Demi M. E. , Brinkhues Stephanie , Dukers-Muijrers Nicole H. T. M. , den Heijer Casper D. J. , Bouwmeester-Vincken Noortje , Hanssen Daniëlle A. T. , van Loo Inge H. M. , Savelkoul Paul H. M. , Hoebe Christian J. P. A. 
Published: May 2022

Background
The availability of valid Severe Acute Respiratory Syndrome Coronvirus-2 (SARS-CoV-2) serological tests overcome the problem of underestimated cumulative Coronavirus Disease 2019 (COVID-19) cases during the first months of the pandemic in The Netherlands. The possibility to reliably determine the number of truly infected persons, enabled us to study initial drivers for exposure risk in the absence of routine testing. Numerous activities or circumstances can accelerate virus spread, here defined as exposure factors. Hence, we aimed to evaluate a wide variety of demographic, behavioural and social exposure factors associated with seropositivity during the first eight months of the pandemic in Limburg, The Netherlands.

Methods
SARS-CoV-2 point-seroprevalence was determined cross-sectionally to indicate previous infection in a convenience sample of minimal 10,000 inhabitants of the study province. All adult (18+ years) inhabitants of the study province were eligible to register themselves for participation. Once the initial 10,000 registrations were reached, a reserve list was kept to ensure sufficient participants. Possible exposure factors were mapped by means of an extensive questionnaire. Associated exposure factors were determined using univariable and multivariable logistic regression models.

Results
Seropositivity was established in 19.5% (n = 1,948) of the 10,001 participants (on average 49 years old (SD = 15; range 18–90 years), majority women (n = 5,829; 58.3%). Exposure factors associated with seropositivity included current education, working in healthcare and not working from home, and being a member of three or four associations or clubs. Specifically for February-March 2020, visiting an après-ski bar during winter sports in Austria, travelling to Spain, celebrating carnival, and participating in a singing activity or ball sport were associated with seropositivity.

Conclusions
Our results confirm that relevant COVID-19 exposure factors generally reflected circumstances where social distancing was impossible, and the number and duration of contacts was high, in particular for indoor activities.
Les ficelles sans le métier
Authors: Czerny Estelle , Lepaux Victor 
Published: May 2022

L’autonomisation universitaire de la médecine générale dans les années 2000 s’est accompagnée de la création d’un champ de recherche qui se veut indépendant et qui emprunte les méthodes de terrain des sciences sociales pour se distinguer de la recherche médicale traditionnelle. Cet article propose de revenir sur les conditions sociales de la réalisation de formations aux méthodes qualitatives à destination d’internes qui réalisent leurs thèses d’exercice. Il explore les usages particuliers de ces méthodes au sein d’un curriculum qui reste orienté vers la pratique médicale, et les conditions spécifiques de transmission des méthodes des sciences sociales dans un cursus qui ne prépare pas à devenir social scientist. Celles-ci se comprennent à la fois par les propriétés des formateurs issus des sciences sociales et des généralistes enseignants, et par les contraintes (temporelles et de positions académiques) auxquelles sont soumis ces différents acteurs et la place accordée à la méthode, à la fois fonction de certification et dissociée de socle théorique.
Enquêtes et projets : pour une hybridation des modalités pédagogiques au sein des écoles d’architecture
Authors: Bossé Anne , Didelon Valéry 
Published: May 2022

Au sein des écoles nationales supérieures d’architecture, le rapprochement avec l’université se traduit notamment par un désir de clarifier « la recherche par le projet » et « le projet par la recherche ». Cet article propose un retour réflexif sur plusieurs expériences pédagogiques menées en cycle master dans des écoles d’architecture françaises entre 2016 et 2021. S’appuyant sur le cadre d’un séminaire de recherche et sur celui d’un atelier de projet, l’article détaille pourquoi enseigner l’enquête aux futurs architectes, et propose de premières bases au « projet par l’enquête ».
The Couple Satisfaction Questionnaire: Development and Validation with Two Italian Samples
Authors: Antonelli Elena , Ronconi Lucia 
Published: May 2022

This paper reports on the development and validation of a questionnaire to measure couple satisfaction in the Italian population, the Couple Satisfaction Questionnaire (CSQ). The CSQ is focused to assess global couple satisfaction, that is the subjective evaluation of one’s couple relationship as a whole. Results: The exploratory factor analysis (EFA) in the pilot study indicated the existence of two dimensions, one positive and one negative with respect to couple satisfaction. This separation has been interpreted as a methodological artifact due to item phrasing. In fact, the confirmatory factor analysis (CFA) in the validation study supported our hypothesis of one latent factor. The CSQ showed to have good psychometric properties, including high internal consistency, and excellent convergent validity. Discriminant validity referring to social desirability was acceptable. Conclusion: The pilot and validation studies’ results suggest that the CSQ is a reliable instrument to assess couple satisfaction in couple or family counselling, and encourage further studies of its psychometric properties.
Risk mitigation by design of autonomous maritime automation systems
Authors: Dittmann Kjeld , Blanke Mogens 
Published: May 2022

Abstract
Autonomous marine surface vehicles rely on computer systems with computer intelligence making decisions to assist or replace the navigating officer. A fundamental requirement for the design and implementation of such a cyber-physical system is seamless, predictable, and secure interoperability between vendor-specific hardware and software subsystems. The article describes a system design that includes mechanisms to mitigate the risks and consequences of software defects, individual component malfunction, and harmful cyber interference. It addresses international regulations in the field and demonstrates a system design that can meet the requirements for safe behaviour in foreseeable events while also having the ability to call for human assistance if the autonomous system is unable to handle a situation. The paper presents a design for highly automated vessels with several inherent risk-reducing features, including the ability to isolate and encapsulate abnormal behaviours, built-in features to support resilience to unexpected events, and mechanisms for internal defence against cyber-attacks. The article shows how this is provided by a novel middleware that supports risk mitigation, dependability, and resilience.
Towards semi-autonomous operation of an over-actuated river ferry
Authors: Koschorrek Philipp , Kosch Martin , Nitsch Maximilian , Abel Dirk , Jürgens Dirk 
Published: May 2022

Abstract
The automation of ships will in the long run enable new mobility concepts and profitable business models both for offshore and inland vessels. However, automation in shipping can already today offer significant benefits for the environment as well as for the safety of people, infrastructure and the vessel itself. To gain these advantages, sophisticated sensors, reliable propulsion systems and intelligent algorithms are required. In this context, the project AKOON is investigating the potential of the automation of a river ferry. The ferry under investigation operates on the Rhine near Mainz in Germany and is being converted to a fully automated vessel as part of the research project. This article gives an overview of the guidance, navigation and control (GNC) modules of the automation with focus on the trajectory planning and trajectory tracking modules. The trajectory planning uses hybrid-state A* to find safe and fuel-efficient routes. The subsequent trajectory tracking is achieved by a two-level approach that uses a state-space controller and an optimization-based thrust allocation to efficiently operate the over-actuated propulsion system consisting of four cycloidal propellers. Results from a high-fidelity vessel simulator based on state-of-the-art hydrodynamic simulations show that the presented approach allows the generation of collision-free reference trajectories, that can be tracked safely even in cases of model mismatches and disturbances.
Review of pose estimation within European ship-automation projects using GNSS-based navigation
Authors: Liu Shuchen , Gehrt Jan-Jöran , Abel Dirk 
Published: May 2022

Abstract
Accurate and reliable navigation systems are necessary to deploy autonomous shipping. For this purpose, georeferenced vehicle-pose information is often generated using sensor data fusion consisting of GNSS data, inertial measurement, and other applicable aiding sensors. This technical overview summarizes current European projects and international work in the field of GNSS-based maritime navigation and introduces and discusses the sensors and methods involved. The review focuses on approaches with proprioceptive sensor technology. Therefore, as a limitation, environment sensing algorithms (e. g., SLAM) are explicitly not included. It is concluded that highly accurate and reliable sensor fusion should include complementary and redundant onboard sensors, which are tightly coupled.
Automation of maritime shipping for more safety and environmental protection
Authors: Ehlers Tobias , Portier Martin , Thoma Doreen 
Published: May 2022

Abstract
The demands on maritime shipping, one of the oldest and most international industries in the world, are increasing. The complexity of the transport chains, their constantly increasing size and the evolving regulatory requirements with regard to safety and sustainability continuously present new challenges. In addition, unforeseeable developments and the increasing utilization of the seas by other industries cause a constant uncertainty, by political and military conflicts along main shipping routes, as well as changed routing schemes caused by introduction of new environmental protection areas. Highly automated, remote-controlled or fully autonomous ships are intended to improve safety at sea and lead shipping into a more sustainable future.
Experts in the maritime domain recommend the automation of ships (completely or partly unmanned) and the implementation of Artificial intelligence (AI) for more safety in navigation with a harmonized Maritime Cyber Risk Management. In a technology development platform such highly complex maritime systems can be validated and tested under realistic conditions, for instance to engage in determining positions more reliably and resiliently in view of the susceptibility and vulnerability of satellite-based Global Navigation Satellite Systems (GNSS), such as GPS, GLONASS or Galileo.
Genome-wide identification and characterization of NBS-encoding genes in the sweet potato wild ancestor Ipomoea trifida (H.B.K.)
Authors: Si Zengzhi , Qiao Yake , Zhang Kai , Ji Zhixin , Han Jinling 
Published: May 2022

Abstract
The most predominant type of resistance (R) genes contain nucleotide-binding sites and leucine-rich repeat (NBS-LRR) domains, characterization of which is helpful for plant resistance improvement. However, the NBS genes of Ipomoea trifida (H.B.K.) remain insufficient to date. In this study, a genome-wide analysis of the NBS-encoding gene in I. trifida (H.B.K.) was carried out. A total of 442 NBS encoding genes were identified, amounting to 1.37% of the total genes of I. trifida (H.B.K.). Based on the analysis of the domains, the identified ItfNBS genes were further classified into seven groups: CNL, NL, CN, N, TNL, TN, and RNL. Phylogenetic analysis showed that the I. trifida NBS genes clustered into three independent clades: RNL, TNL, and CNL. Chromosome location analysis revealed that the distribution of ItfNBS genes in chromosomes was uneven, with a number ranging from 3 to 45. Multiple stress-related regulatory elements were detected in the promoters of the NBS-encoding genes, and their expression profiles were obtained. The qRT-PCR analysis revealed that IbNBS10, IbNBS20, IbNBS258, and IbNBS88 responded to stem nematode infection. These results provide critical proof for further characterization and analysis of NBS-encoding genes with important functions.
Association between single-nucleotide polymorphisms of NKX2.5 and congenital heart disease in Chinese population: A meta-analysis
Authors: Chen Huan , Li Tianjiao , Wu Yuqing , Wang Xi , Wang Mingyuan , Wang Xin , Fang Xiaoling 
Published: May 2022

Abstract

NKX2.5 is a transcription factor that plays a key role in cardiovascular growth and development. Several independent studies have been previously conducted to investigate the association between the single-nucleotide polymorphism (SNP) 606G >C (rs3729753) in the coding region of NKX2.5 and congenital heart disease (CHD). However, the results of these studies have been inconsistent. Therefore, the present study aimed to reveal the relationship between NKX2.5 SNP 606G >C and the risk of CHD as possible in the Chinese population through meta-analysis. After retrieving related articles in PubMed, MEDLINE, EMBASE, Web of science, Cochrane, China National Knowledge Infrastructure, Wanfang DATA, and VIP database until August 2021, a total of eight studies were included in the present meta-analysis. The qualified research data were then merged into allele, dominant, recessive, heterozygous, homozygous, and additive models. Overall results of the current meta-analysis showed that 606G >C was not associated with CHD of the Chinese population in any model. In addition, subgroup analysis based on CHD type gave the same negative result. Results of sensitivity analysis showed that there was no significant correlation after the deletion of each study. Furthermore, it was noted that the results were negative and the heterogeneity was not significant. In conclusion, it was evident that NKX2-5 SNP 606G >C may not lead to the risk of CHD in Chinese population.
Trace-Class and Nuclear Operators
Authors: Kubrusly Carlos S. 
Published: May 2022

Abstract
This paper explores the long journey from projective tensor products of a pair of Banach spaces, passing through the definition of nuclear operators still on the realm of projective tensor products, to the of notion of trace-class operators on a Hilbert space, and shows how and why these concepts (nuclear and trace-class operators, that is) agree in the end.