bluuebunny/crossref_metadata_2025_split huggingface dataset:
Glycine Catalyzed One-Pot Three-Component Synthesis of Structurally
Diverse 2-Amino Substituted Pyran Annulated Heterocycles in Aqueous
Ethanol under Refluxed Conditions
Authors: Banerjee Bubun , Kaur Manmeet , Sharma Aditi , Singh Arvind , Priya Anu , Gupta Vivek Kumar , Jaitak Vikas 
Published: December 2022

INTRODUCTION:
A facile, convenient and general method has been developed for the one-pot three-component synthesis of structurally diverse 2-amino pyran annulated heterocycles from the reactions of aromatic aldehydes, malononitrile and various C-H activated acids in the presence of a catalytic amount of glycine as an efficient metal-free organocatalyst in aqueous ethanol under refluxed conditions.

METHOD:
Using this developed protocol, we were able to synthesize a series of structurally diverse 2-amino pyran derivatives viz., 2-amino-4,5-dihydropyrano[3,2-c]chromenes, 2-amino-4,5-dihydropyrano[4,3-b]pyrans, 2-amino-5,6,7,8-tetrahydro-4H-chromenes, 2'-amino-2,5'-dioxo-5'H-spiro[indoline-3,4'-pyrano[3,2-c]chromene]-3'-carbonitrile and 2'-amino-1,3,5'-trioxo-1,3-dihydro-5'H-spiro[indene-2,4'-pyrano[3,2-c]chromene]-3'-carbonitrile in excellent yields.

RESULT:
Synthesis of biologically promising pyrans and spiropyrans, high atom economy, excellent yields, use of metal-free catalyst, less toxic solvents, no chromatographic column purifications, multiple carbon-carbon and carbon-heteroatom bond formations are some of the major advantages of this newly developed protocol.
Determinants of Implementation of a Critical Care Registry in Asia: Lessons From a Qualitative Study
Authors: Tolppa Timo , Pari Vrindha , Pell Christopher , Aryal Diptesh , Hashmi Madiha , Shamal Ghalib Maryam , Jawad Issrah , Tripathy Swagata , Tirupakuzhi Vijayaraghavan Bharath Kumar , Beane Abi , Dondorp Arjen M , Haniffa Rashan ,   Collaboration of Research Implementation & Training in Critical Care in Asia Investigators
Published: December 2022

Background
The Collaboration for Research, Implementation, and Training in Critical Care in Asia (CCA) is implementing a critical care registry to capture real-time data to facilitate service evaluation, quality improvement, and clinical studies.

Objective
The purpose of this study is to examine stakeholder perspectives on the determinants of implementation of the registry by examining the processes of diffusion, dissemination, and sustainability.

Methods
This study is a qualitative phenomenological inquiry using semistructured interviews with stakeholders involved in registry design, implementation, and use in 4 South Asian countries. The conceptual model of diffusion, dissemination, and sustainability of innovations in health service delivery guided interviews and analysis. Interviews were coded using the Rapid Identification of Themes from Audio recordings procedure and were analyzed based on the constant comparison approach.

Results
A total of 32 stakeholders were interviewed. Analysis of stakeholder accounts identified 3 key themes: innovation-system fit; influence of champions; and access to resources and expertise. Determinants of implementation included data sharing, research experience, system resilience, communication and networks, and relative advantage and adaptability.

Conclusions
The implementation of the registry has been possible due to efforts to increase the innovation-system fit, influence of motivated champions, and the support offered by access to resources and expertise. The reliance on individuals and the priorities of other health care actors pose a risk to sustainability.
Predicting Smoking Prevalence in Japan Using Search Volumes in an Internet Search Engine: Infodemiology Study
Authors: Taira Kazuya , Itaya Takahiro , Fujita Sumio 
Published: December 2022

Background
Tobacco smoking is an important public health issue and a core indicator of public health policy worldwide. However, global pandemics and natural disasters have prevented surveys from being conducted.

Objective
The purpose of this study was to predict smoking prevalence by prefecture and sex in Japan using Internet search trends.

Methods
This study used the infodemiology approach. The outcome variable was smoking prevalence by prefecture, obtained from national surveys. The predictor variables were the search volumes on Yahoo! Japan Search. We collected the search volumes for queries related to terms from the thesaurus of the Japanese medical article database Ichu-shi. Predictor variables were converted to per capita values and standardized as z scores. For smoking prevalence, the values for 2016 and 2019 were used, and for search volume, the values for the April 1 to March 31 fiscal year (FY) 1 year prior to the survey (ie, FY 2015 and FY 2018) were used. Partial correlation coefficients, adjusted for data year, were calculated between smoking prevalence and search volume, and a regression analysis using a generalized linear mixed model with random effects was conducted for each prefecture. Several models were tested, including a model that included all search queries, a variable reduction method, and one that excluded cigarette product names. The best model was selected with the Akaike information criterion corrected (AICC) for small sample size and the Bayesian information criterion (BIC). We compared the predicted and actual smoking prevalence in 2016 and 2019 based on the best model and predicted the smoking prevalence in 2022.

Results
The partial correlation coefficients for men showed that 9 search queries had significant correlations with smoking prevalence, including cigarette (r=–0.417, P<.001), cigar in kanji (r=–0.412, P<.001), and cigar in katakana (r=-0.399, P<.001). For women, five search queries had significant correlations, including vape (r=0.335, P=.001), quitting smoking (r=0.288, P=.005), and cigar (r=0.286, P=.006). The models with all search queries were the best models for both AICC and BIC scores. Scatter plots of actual and estimated smoking prevalence in 2016 and 2019 confirmed a relatively high degree of agreement. The average estimated smoking prevalence in 2022 in the 47 prefectures for the total sample was 23.492% (95% CI 21.617%-25.367%), showing an increasing trend, with an average of 29.024% (95% CI 27.218%-30.830%) for men and 8.793% (95% CI 7.531%-10.054%) for women.

Conclusions
This study suggests that the search volume of tobacco-related queries in internet search engines can predict smoking prevalence by prefecture and sex in Japan. These findings will enable the development of low-cost, timely, and crisis-resistant health indicators that will enable the evaluation of health measures and contribute to improved public health.
Incidence and Risk Factors for Pruritus in Patients with Nondialysis CKD
Authors: Wulczyn Kendra E. , Rhee Eugene P. , Myint Leslie , Kalim Sahir , Shafi Tariq 
Published: December 2022

Background
Pruritus is a common symptom experienced by patients with nondialysis CKD, but risk factors for incident pruritus in this patient population have not been evaluated.

Methods
We identified 1951 participants with CKD in the Chronic Renal Insufficiency Cohort Study without pruritus at the baseline assessment. Pruritus was assessed by the Kidney Disease Quality of Life-36 (KDQOL-36) instrument, and moderate-to-severe pruritus was defined as a response of 3 or higher on a Likert scale of 1–5. We used time-updated multivariable joint models to evaluate the association of patient clinical characteristics, eGFR, and laboratory parameters with incident pruritus.

Results
Over a median follow-up of 6 years, 660 (34%) participants developed incident moderate-to-severe pruritus, with a higher incidence rate observed among participants with more advanced CKD. In multivariable models, the hazard ratio (95% confidence interval [CI]) for pruritus associated with a 10 ml/min per 1.73 m2 lower eGFR was 1.16 (95% CI, 1.10 to 1.23). Older age (≥65 years), higher body mass index, diabetes, current smoking, opioid use, depressive symptoms, and serum parathyroid hormone were also associated with a higher risk of incident pruritus, whereas low serum calcium (<9 mg/dl) was associated with a lower risk (all P<0.05). Serum phosphate was not associated with incident pruritus in the primary analysis.

Conclusions
A substantial proportion of patients with nondialysis CKD develop moderate-to-severe pruritus. Although lower eGFR is associated with the risk of pruritus, other comorbidities, particularly depressive symptoms, were potential risk factors.

Podcast
This article contains a podcast at https://dts.podtrac.com/redirect.mp3/www.asn-online.org/media/podcast/CJASN/2023_02_08_CJN09480822.mp3
ГЛУБИННАЯ БИОСФЕРА ЗЕМЛИ, СОВРЕМЕННАЯ И ДРЕВНЯЯ
Authors: Беляев Анатолий , Юхалин Павел 
Published: December 2022

Анализ изученности современной глубинной биосферы Земли позволяет предположить, что ее вещество участвует в глобальном биологическом круговороте. Глубинные воды, содержащие подземные микроорганизмы, могут выходить наружу в артезианских источниках, и на континентальных склонах, обогащая органическим веществом зоны апвеллинга и океанические течения. При этом, минерализованные подземные воды имеют возможность постоянного движения, за счет ритмичного изменения внутрипородного давления при ежесуточных земных приливах и отливах.
Наиболее благоприятные условия для обитания колониальных микроорганизмов древней глубинной биосферы существовали внутри горных пород в полостях агатовых камер, до заполнения их кремнистым веществом. Подземные организмы образовывали на стенках агатовых полостей слоистые, пузырчатые, ветвистые и почковидные структуры, подобные бактериальным матам, впоследствии замещенные кремнистым веществом. Зональные микро- и макроритмы в полосчатых агатах формировались в результате отложения осадочного кремнистого вещества из проточных кремнийсодержащих растворов при пульсационном изменении давления во время каменных приливов. Позднее, под воздействием литостатического давления, в уже затвердевших структурах агатовых жеод, возникали поля разнонаправленных динамических напряжений, приводивших к раскристаллизации (девитрификации) кремнистого вещества и формированию микролитов халцедона.
Морфологическое многообразие ветвистых, пузырчатых и почковидных структур в агатах может свидетельствовать о биоразнообразии древних глубинных организмов.
Adult Concentration Inventory (ACI) Brazilian Portuguese version: cross-cultural adaptation and validation study
Authors: Godoy Victor Polignano , Silva Lorena de Paula , Serpa Alexandre Luiz Oliveira , Malloy-Diniz Leandro Fernandes 
Published: December 2022

Introduction: Sluggish Cognitive Tempo (SCT) designates a group of symptoms related to impairments in valuable life domains. Objectives: The aims were to translate, adapt and validate a psychometrically informed scale of SCT, the Adult Concentration Inventory (ACI), for the Brazilian context. Method: The scale was translated, back-translated, and evaluated by an expert panel. After the semantic equivalence analysis, 446 participants (295 women) aged 18 to 65 years (M = 34.99, SD = 10.7) answered an internet-based survey. An Exploratory Factor Analysis (EFA) was conducted with the items of the ACI, Adult Self Report Scale (ASRS-18), the Self-Report Questionnaire (SRQ-20) to evaluate the convergent and discriminant validity of ACI items. A Confirmatory Factor Analysis (CFA) was performed to test the ACI latent structure. Correlations between ACI, ASRS-18 and SRQ-20 were also calculated. Results: The experts’ semantic equivalence analyzes pointed to 85% of average agreement. The EFA with ACI, ASRS-18, and SRQ-20 showed 10 ACI items with acceptable convergent and discriminant validity. The most suitable solution in the CFA was the one-factor model (RMSEA = 0.039 [IC90%: 0.0 – 0.09]; CFI = 0.997; TLI = 0.996). The reliability was satisfactory (α = 0.920). The correlations between ACI measures and the ASRS-18 inattention were high. Conversely, the correlations with the ASRS-18 hyperactivity-impulsivity were of medium intensity and when controlling for inattention became non-significative. Conclusion: Overall, the preliminary results showed the reliability and validity of the ACI Brazilian Portuguese version. Further studies should focus on determining the generalization and measurement invariance of these findings.
Obrar en consecuencia. La lógica de la experiencia de John Dewey
Authors: Arenas Llopis Luis 
Published: December 2022

A pesar del escaso eco que las contribuciones de Dewey parecen haber logrado en el campo de la lógica, la ampliación que ha sufrido la disciplina lógica en la segunda mitad del siglo XX y en lo que llevamos del siglo XXI puede considerarse en muchos sentidos una confirmación de las ideas de Dewey en torno al papel de la lógica en el conjunto del saber. La lógica, en el preciso sentido que Dewey otorga al término, ha sido la preocupación constante del recorrido intelectual de Dewey y es la cima que corona su proyecto de una naturalización de la filosofía. En el caso de la lógica, ese proyecto pasa por mostrar en qué sentido las formas lógicas surgen en la operación de investigar y se ocupan de controlar la investigación para que esta pueda producir aserciones garantizadas. Lo que tendrá como consecuencia asumir el carácter empírico de los principios lógicos y una reformulación radical del problema clásico de la verdad.
Retrospective analysis of experience of treatment of complex choledocholithiasis
Authors: Grubnik V. V. , Evsikov B. V. , Gerasimov D. V. 
Published: December 2022

Objective. Estimation of the clinical results application, concerning various methods of the complex choledocholithiasis treatment.
Materials and methods. The investigation was conducted on the base of Odessa Regional Clinical Hospital during 2018 - 2021 yrs. Retrospective analysis of clinical results in treatment of 69 patients with complex choledocholithiasis was accomplished.
Results. The tactics of treatment choice in complex choledocholithiasis must be maximally individualized and depend on a patient state and presence of concurrent diseases. In severe state of a patient the treatment must be started with transhepatic drainage of biliary ducts. It permits to eliminate the cholangitis signs, to improve a patient state and to prepare him to more complex operative interventions.
Conclusion. In complex choledocholithiasis it is expedient to perform a two-staged interventions with preliminary drainage of biliary ducts for the cholemia level lowering. Tactics of treatment of complex choledocholithiasis must be selected, taking into account the patient state and age, presence of concomitant pathology and the clinic-anatomic peculiarities of the disease course (dimensions of calculi, stenosis, diverticulas of common biliary duct, etc). The extended endoscopic interventions constitute the most secure option.
Impact of Drought on the Life Cycle of Barge Transport
Authors: Garcia Breno Tostes de Gomes , De Medeiros Alexandre Simas , Do Nascimento Filipe Almeida Corrêa , Da Silva Marcelino Aurélio Vieira 
Published: December 2022

This paper aims to analyze the impact of drought on the life cycle of barge transportation. The LCA method was used to quantify the environmental impact of barge transportation services on the Madeira River/Brazil: Transportation Operation, Barge Fleet, and Waterway Infrastructure. A model for barge convoy formation was developed as a function of river water level variation. From this, the transport operation was simulated, considering the loading of grains from the Madeira River in 2021, as well as the respective fuel consumption and CO2Eq emissions. The results indicate that barge transportation is more harmful to the environment during drought, since only a convoy of nine barges is allowed to navigate, and its energy efficiency is compromised due to the longer travel time and lower loading capacity in one trip. The intense use of this barge convoy implied an increase of 22.25% in CO2Eqemissions when compared to the full river. Doi: 10.28991/CEJ-2022-08-12-02 Full Text: PDF
ПСИХОЛОГІЧНІ МЕХАНІЗМИ ІНФОРМАЦІЙНОГО ВПЛИВУ НА ОСОБИСТІСТЬ ДОРОСЛОЇ ЛЮДИНИ
Authors: Кузіна Євгенія 
Published: December 2022

Мета статті полягає у теоретичному обґрунтуванні психологічних механізмів інформаційного впливу на особистість дорослої людини та практичній реалізації запропонованої психологічної моделі.
Методи. В роботі використано теоретичні методи, так і як: аналіз, синтез, порівняння, абстрагування та узагальнення теоретичних фактів щодо інформаційного впливу та особистісної зрілості, а також експериментально проведено апробацію тренінгової програми «Розвиток інформаційної зрілості».
Результати. У статті висвітлено результати наукових пошуків в галузі медіапсихології. Автор звернув увагу на ті негативні сторони інформаційного прогресу, які значним чином впливають на людину, створюють дезінформацію та шкодять психологічному благополуччю. Представлено цінності та характеристики інформаційного суспільства як нового етапу існування людства. На прикладах продемонстровано як людина може упереджено ставитись до нової інформації. Виявлено, що вразливість до медіа-контенту залежить як від характеристик інтелекту, індивідуальної сприйнятливості та тих медіа прийомів які були використані. На основі цих головних компонентів автор запропонував модель психологічних механізмів інформаційного впливу яка полягає у їх поєднанні. Обґрунтовано доцільність розробки та впровадження тренінгової програми, яка спрямована на розвиток інформаційної зрілості. Описано процес апробації та структурні компоненти програми: психоекудація щодо медіагігієни, розвиток критичного мислення, формування навички усвідомленого вибору, підвищення рівня когнітивних здібностей, розвиток особистісної зрілості.
Висновки. З’ясовано, що існує нагальна необхідність у дослідженні механізмів інформаційного впливу та розробці інструментарію який буде допомагати протистояти негативним медіа-ефектам. Встановлено певні психологічні закономірності сприйнятливості інформаційному впливові. Запропонована програма може бути використана як навчальний або розвивальний матеріал у закладах освіти та в роботі практичного психолога. Стаття є логічним продовженням досліджень автора з теми інформаційного впливу на особистість.
Percepción y Características del Teletrabajo por los empleados en el periodo Postpandemia
Authors: Ulloa Duque Gabriela Soledad , Araiza Vázquez María de Jesús 
Published: December 2022

El teletrabajo es la nueva forma de trabajar, consecuencia de una pandemia que no se esperaba y que llegó para quedarse, comprender lo que se cree conocer del teletrabajo y sus características después de dos años de pandemia es necesario para continuar con esta modalidad de manera exitosa. Por consiguiente, el presente estudio tiene como objetivo mostrar que las principales características del teletrabajo que son Autonomía, Falta de Información y Aislamiento están ligadas a factores estresantes como sobrecarga de trabajo, conflicto entre el trabajo y la familia y ambigüedad de rol y si influyen o no, de acuerdo con la percepción del teletrabajador en el agotamiento que produce el teletrabajar y la intensión de continuar trabajando de manera remota. Se realizo una investigación de diseño no experimental con un enfoque cuantitativo y alcance descriptivo considerando una muestra de 235 teletrabajadores. Para la recolección de información se consideró un instrumento tipo encuesta diseñado con ítems tipo Likert. El análisis de datos se basa en un modelo de ecuaciones estructurales y dentro de los resultados se tiene que a mayor aislamiento en el teletrabajo mayor es la sobrecarga de trabajo percibida por los que hacen teletrabajo y que la ambigüedad de rol se relaciona de manera positiva y muy fuerte con el agotamiento en el teletrabajo, más sin embargo tiene un efecto indirecto parcial con la intención de seguir teletrabajando.
Il bucato di Nausicaa Una nuova lettura di Sofocle, fr. 439 R. (Ναυσικάα ἢ Πλύντριαι)
Authors: Carrara Laura 
Published: December 2022

The article starts by reviewing the main evidence concerning Homeric influence on Sophocles’ poetry, with the goal of creating an effective background for the analysis of the presumably most Homeric of his plays, the lost Ναυσικάα ἢ Πλύντριαι (Nausicaa or The Washerwomen). This play demonstrably dramatized the meeting between the castaway Odysseus and the Phaeacian princess as told in OdysseyVI; only three fragments survive (439-441 R.). The article suggests a Homeric hypotext taken from an early scene of that book – the laundry of Nausicaa’s maidens – for fr. 439 R., borne out by a new reading of the much-discussed verb of the line.
Variability of Genetic Parameters of Reindeer Populations of the Chukchi Breed in time and geographical area
Authors: Bryzgalov G. , Ignatovich L. 
Published: December 2022

Purpose: Studying the genetic parameters of the population of the Northern Deer of the Chukotka breed according to fragments of molecular multi -cosmic analysis of DNA.Materials and methods. The northern deer, participating in the experiment year -round grazed on natural pastures without additional feeding. The material for the research was the fabric samples (faster of the auricle) of deer of different sexual age groups. Sampling was carried out by a random method from clinically healthy animals during coral work. Analytical work was carried out in the laboratory of DNA technologies of the All-Russian Research Institute of Tribal case using ISSR-PCR method according to the primer (AG) 9C. DNA allocation and PCR production was carried out with generally accepted methods. For calculations, DNA fragments from 180 to 1400 pp were used, clearly distinguishable visually and form pronounced peaks during computer scanning of gels.Results. Statistically significant differences between populations in the frequencies of ISSR markers were found in the interval of 1 year in 4-7 loci of 11 identified, through generation-from 1 to 4 loci. With an increase in the temporary interval between observations from 1 year to 5 years, changes in the genome by the number of loci and in the frequencies of ISSR markers were not noted. In all cases, the populations of microsatellites identified were in a state of gene equilibrium. Factors stabilizing the genetic structure of the population of the Chukotka breed are free mating characteristic of the northern deer, a significant number of males participating in the reproduction of the herd. Between populations from various ecological and geographical areas of Chukotka, 6 locus (54.5% of cases) have statistically significant differences in the frequencies of ISSR markers. The population in the Arctic tundra area exceeded the population from the forest tundra along short loci (180-210 pp) and (330- 350 pp) at p <0.001, locals of medium length (350-430 pp) <0.05. In turn, the forest-tundra population exceeded the Arctic population in long loci (700-1300 pp) at p <0.001. Ecological and geographical conditions determine the frequency of ISSR markers in the populations of the Chukchi breed, thereby, being a factor in intraspecific differentiation. Considering that the number of Chukotka breed deer is reduced, constant monitoring of the gene pool is needed. The research was carried out with the financial support of the RFBR in the framework of scientific project No. 20-316-90042.