bluuebunny/crossref_metadata_2025_split huggingface dataset:
MEMODELKAN PRODUK DOMESTIK REGIONAL BRUTO DI INDONESIA MENGGUNAKAN REGRESI DATA PANEL SPASIAL
Authors: ASTUTI NI KADEK AYU PUJI , SUCIPTAWATI NI LUH PUTU , SUSILAWATI MADE 
Published: September 2022

Gross regional domestic product (GRDP) is one of the important indicators to determine economic conditions in a region. The magnitude of the growth rate of GRDP is developed by the progress of regional economic development, both carried out by the government and the private sector in order to improve the welfare of the population. The purpose of this study is to examine the business sector that has the most significant influence on GRDP in Indonesia by applying spatial panel data regression. The results show that the best model in modeling GRDP in Indonesia is the spatial lag common effect which has an value of 83,13% while the independent variables that are significant to the increase in GRDP can be divided into two, namely significant positive and significant negative effects. The variables that have a significant and positive effect on GRDP are agriculture, forestry, and fisheries , mining and quarrying electricity and gas supply, water supply, waste management, waste and recycling, construction, financial services and insurance, real estate, and other services. wholesale and retail trade; car and motorcycle repair, transportation and warehousing, company services education services .
IMPLEMENTASI FUZZY C-MEAN DAN ALGORITMA PARTICLE SWARM OPTIMIZATION UNTUK CLUSTERING KABUPATEN/KOTA DI INDONESIA BERDASARKAN INDIKATOR INDEKS PEMBANGUNAN MANUSIA
Authors: DWIGUNA I KADEK SONA , GANDHIADI G.K. , HARINI LUH PUTU IDA 
Published: September 2022

This research is aimed to determine conduct clustering in accordance with the conditions of districts / cities throughout Indonesia based on the IPM indicator and to determine the performance comparison of Fuzzy C-Means using particle swarm optimization compared to ordinary fuzzy c mean. The study uses 514 district / city data in Indonesia based on four IPM indicators. The research show 4 clusters that describe the condition of the Indonesian region and based on the results of cluster validation shows that there are differences in the ordinary Fuzzy C-Means mean algorithm and Fuzzy C-Means using particle swarm optimization.
Immunohistochemical evaluation for integrin binding sialoprotein on healing process of intrabony defect treated by bone sialoprotein
Authors: Jaafar Mayada K. , Kadhim Enas F 
Published: September 2022

Background: Bone defect healing is a multidimensional procedure with an overlapping timeline that involves the regeneration of bone tissue. Due to bone's ability to regenerate, the vast majority of bone abnormalities can be restored intuitively under the right physiological conditions. The goal of this study is to examine the immunohistochemistry of bone sialoprotein in order to determine the effect of local application of bone sialoprotein on the healing of a rat tibia generated bone defect. Materials and Methods: In this experiment, 48 albino male rats weighing 300-400 grams and aged 6-8 months will be employed under controlled temperature, drinking, and food consumption settings. The animals will be subjected to a surgical procedure on the medial side of the tibiae bone, with the bone defect repaired with absorbable hemostatic material in the control group (12 rats). The experimental group (12 rats) will be treated with local administration of 30 μl bone sialoprotein fixed by absorbable hemostatic sponge. After surgery, the rats will be slaughtered at 7, 14, and 28 days (four rats for each period). Results: Immunohistochemical analysis of bone sialoprotein by stromal cells reveal a substantial difference between the bone sialoprotein group and the control group. Conclusion: The study concludes that local application of bone sialoprotein could be a successful therapeutic treatment for bone injuries; these findings are encouraging for future clinical use.
12- months color stability of direct resin composite veneers in anterior teeth: Clinical trial
Authors: Abdulateef Omar F , ÇOBANOĞLU Nevin 
Published: September 2022

Background: This clinical trial aims to evaluate the color changes of direct resin composite veneer (DCV) restorations based on spectrophotometric analysis of 4 different types of resin composites between the baseline immediately after polishing and after one year of follow-up. Materials and methods: 28 patients were assessed for eligibility for participation, aged between 18 and 38 years old, who indicated for DCV restorations in anterior maxillary teeth were considered for participation in this study. In total, 25 patients who met the inclusion criteria were selected (6 males and 19 females, mean age: 20.9 at the time of restoration placement), and 3 patients were excluded. Participants were divided into four groups based on the type of composite resin used for restorations. Group 1 nanohybrid Ips Empress direct (Ivoclar Vivadent)](IPS) (13 restorations/6 patients), group 2 microfilled [Essentia (GC cooperation Japan)](ES) (14 restorations / 7 patients), group 3 supra-nano filled [ Estelite ∑ Quick (Tokuyama, Tokyo, Japan)](EQ) (17 restorations / 7 patients) and group 4 nanofill [Filtek Ultimate (3M ESPE)](FU) (13 restorations / 5 patients). Baseline Color measurements were performed with a spectrophotometer immediately after finishing and polishing (baseline), and after one year of recall, color change (ΔE) from baseline values and after one year of follow-up of DCVs were calculated according to CIELab color coordinates. For this, a silicone mold was fabricated for each patient and used as a guide for each measurement to standardize the site of the readings. Statistical analysis of the data was applied using the Kruskal-Wallis test with Dunn-Bonferroni posthoc test after controlling the distribution of data in terms of normality with the Shapiro Wilk test. Results: At the end of one year,25 participants(57restorations) were followed up. The mean ΔE of IPS, EQ, and FU composites were higher than the ES composite resin, but there was no statically significant difference between all types of composites (P> 0.05). There was no statistically significant difference in the mean ΔL* between any types of composite resin (p> 0.05). There was a significant change in Δa* and Δb* after a one-year recall for all the types of DCV restorations (p < 0.05). Conclusion: After one year of follow-up, the spectrophotometer measurements of direct resin composite veneer restorations, it was concluded no difference between the mean ΔE of ES, IPS, FU, and EQ resin composite. ES (Microfilled hybrid) showed a lower mean ΔE value compared to the other groups. All groups of resin composite showed color changes within clinically acceptable levels after a one-year follow-up.
Living Together: Intergenerational Living in Aotearoa New Zealand
Authors:   , Kondo Erika 
Published: September 2022

<p><b>In recent years, isolation and loneliness have become prevalent social issues in Aotearoa New Zealand. These issues are becoming more serious as the population ages rapidly and there is an increase in the number of people living on their own. </b></p>
<p>Up until the early 20th century, it was common for a family, and extended families, to live intergenerationally under the same roof. Studies have indicated that Intergenerational Living (IGL) has many emotional and practical benefits. </p>
<p>However, IGL is not highlighted and discussed in New Zealand. This thesis aims to fill this gap and proposes that IGL can help mitigate social issues caused by isolation and loneliness. I discuss these social issues and suggest design solutions for various household types that focus on different family dynamics, cultural practices, and communal spaces that encourage social interaction. </p>
<p>This thesis follows an iterative research process where Design-led research and Research -led design are integrated to explore the research question, “What are the architectural implications of Intergenerational living in Aotearoa New Zealand?” To answer this question, I investigated three key components of IGL relevant to the New Zealand context.</p>
<p>•	How the diverse cultures of New Zealand will play a role in IGL arrangements•	How IGL will work in an urban environment where spaces are limited•	An IGL framework and specific design solutions</p>
Renewable Energy (Solar and Wind) Generation and its Effect on some Variables for Selected EU Countries with Panel VAR Model
Authors: Alam Shahi Md. Tanvir 
Published: September 2022

Keeping the world livable, the policy makers are giving their extended focus on green energy. They are trying to move on hand-on-hand with rising green energy and lessening carbon dioxide (CO2) emission steading the economic activities specially for the open and developing countries. This can be helpful to provide a more lucrative economic environment to meet the extended demand of the society. The paper highlights to find out whether the economic growth, renewable energy consumption, fossil fuel-based energy generation and CO2 emission are significantly impactful on renewable energy generation or not? Is there any mutual, bi-directorial, unidirectional relationship with each other? For this, the Vector Autoregression (VAR) model is run. The paper focuses on six EU countries who are practicing auction scheme for deploying robust green energy (especially solar and wind) by reducing dependency on fossil fuel and expanding their economy with less CO2 emission. The result of the analysis shows that a positive influence of each concern variable on renewable energy (RE) generation and auction scheme might have a significant impact if robustness of the generation occurs.
Research Trends of Waste Heat Recovery Technologies: A Bibliometric Analysis from 2010 to 2020
Authors: Pena Alfonso Rodríguez , Cambronel Daniel Maestre , Ochoa Guillermo Valencia , Henríquez Lisandro Vargas 
Published: September 2022

Waste heat recovery (WHR) technologies have become vital to promote efficient operation in energy systems. The present investigation presents a bibliometric analysis of the research trends in the WHR field in the last decade (2010-2020). The study implements advanced methodologies to gather relevant information for interested readers on this topic. Results indicated that WHR technologies have registered more than 14,000 articles in the selected timeline with an increasing tendency. Moreover, the number of citations escalated to more than 25 % in 2020, using 2010 as the baseline. Three primary research clusters stated that power cycles are the most cited topic in the WHR field. The journal “Energy” featured the highest citation margin, whereas the most relevant author from the database was Adrian Bejan. Lastly, China is leading the progress in the number of articles and subsequently the citation score, which is primary promoted by the “Chinese Academy of Science”. The study identified that the reduction of citations of WHR topics in the last 5 years might be primarily attributed to a transition in a more complex concept of multigeneration. In conclusion, the area of WHR technologies has maintained an increased interest in academia in the last 10 years while contributing to the exploitation of power cycle proposals, turbomachinery, heat exchangers, among others. Also, WHR plays a central role in the development of the next generation of multigeneration units.
Repurposing the Archive: Unmade Films,Vampirellaand Adaptation
Authors: Foster Kieran 
Published: September 2022

The Hammer Script Archive is held at De Montfort University in Leicester and was opened to researchers in 2012. Primary materials held in the Archive include screenplays, treatments, financial documentation, correspondence, posters, production stills and press books. This article will utilise specifically the material held in the Archive that relates to Hammer’s unmade films. The archive currently holds files on exactly 100 unmade television and film projects, with 185 separate pieces of ephemera directly related to these unmade works.This article examines how archival materials on unmade or unreleased films not only provide valuable evidence for revisionist film histories but can also be repurposed as events and media that imaginatively reconstitute unrealised projects. While archives are valued by film historians for the contextual evidence that they provide, and are often the only sources of information about films that are lost, when it comes to films that never were, they hold potential beyond the circumstantial.Unmade films have also been used to frustrate and complicate existing methodologies. But here, papers on unmade films in the Hammer Script Archive provide the point of departure for an examination of the unproduced project Vampirella, which was developed in the mid-1970s, and its subsequent adaptation as a script read live in 2019. As such, documentation in the Archive will be used to provide the production contexts for the original unmade film from which the script was adapted, and then studied to see how these primary materials were repurposed in the subsequent publicly read script. By examining this public event and two other live readings of scripts adapted from unmade Hammer projects, this article will explore the appeal and cultural function of this phenomenon. In doing so it will pose questions about the scripts’ status as adaptations (part-augmentations, part-simulacra?) and fan response (nostalgia for that which never was). What can the film historian recover from such creative plundering of the archive that might be useful methodologically?
Novel botanical active component derivatives containing carboxamide and 1,3,4-Thiadiazole thioether moieties: Design, synthesis, and inhibitory activity
Authors: Li Pei , Chen Cong , Zhu Rongxi , Yang Guixia , Xu Min , Wan Guanghua , Wang Xiang 
Published: September 2022

In this study, using the botanical active components of carvacrol, thymol, guaiacol, and sesamol as the lead structures, 19 novel botanical active component derivatives containing carboxamide and 1,3,4-thiadiazole thioether moieties (5a−5s) were synthesized and structurally characterized by 1H NMR, 13C NMR, and HRMS. The antibacterial bioassay results in vitro showed that compound 2-(2-methoxyphenoxy)-N-(5-(methylthio)-1,3,4-thiadiazol-2-yl)acetamide (5k) revealed excellent inhibitory activities against Xanthomonas axonopodis pv. citri (Xac) and Xanthomonas oryzae pv. oryzicolaby (Xoc), with the median effective concentration (EC50) values of 22 and 15 μg/ml, respectively, which were even better than those of thiodiazole copper and bismerthiazol. Meanwhile, all the target compounds revealed lower in vitro inhibitory effects on Mucor bainieri (M. bainieri), Mucor fragilis (M. fragilis), and Trichoderma atroviride (T. atroviride), than carbendazim.
The impact of pelvic floor electrical stimulation on vaginal microbiota and immunity
Authors: Zhang Yakun , Yang He , Zhang Chi , Lin Li , Yang Wenlan , Xiong Guangwu , Gao Guolan 
Published: September 2022

Pelvic floor electrical stimulation (ES) is an effective treatment for pelvic floor dysfunction. However, the impact of ES on vaginal microbiota and local inflammatory response is yet poorly understood. Therefore, we designed a longitudinal study to investigate the impact of ES on vaginal microbiota and cytokines. A total of 170 participants were recruited into the study at Peking University International Hospital, Beijing, China, from December 2021 to April 2022. They were divided into two groups concerning the follow-up: long-term cohort (n = 147) following up to seven treatment sessions and short-term cohort (n = 23) following up to 7 h after a 30-min treatment. Paired vaginal discharge samples were collected from 134 individuals. Vaginal microbiota was characterized by 16S rRNA sequencing, and local cytokines concentrations were detected by the cytometric bead array method. A significant increase in the relative abundance of Lactobacillus spp. was observed after ES treatment (P &lt; 0.001). In addition, L. crispatus (P = 0.012) and L. gasseri (P = 0.011) also increased significantly. Reduced microbial diversity was observed in the vaginal microbiota after the treatment. In the long-term cohort, a significant downregulation of IFN-γ, IL-2, IL-4, IL-10, IL-17A, and TNF-α was compared with baseline. However, the short-term cohort presented with an elevated IL-6 level at 7 h after the treatment. In conclusion, this study suggested that transvaginal electrical stimulation might help to restore and maintain a healthy vaginal microbiota dominated by Lactobacillus, reducing the risk of vaginal inflammation.
Refractory Helicobacter pylori infection and the gastric microbiota
Authors: Liu Dongsheng , Wang Jinyun , Xie Yong 
Published: September 2022

BackgroundCuring refractory Helicobacter pylori infection is difficult. In addition, there is currently no research on the gastric microbiota of refractory H. pylori infection.MethodsWe designed a clinical retrospective study involving 32 subjects divided into three groups: 1. nAGHp.a, treatment-naïve patients with H. pylori infection; 2. nAGHp.b, H. pylori-negative patients; and 3. EFHp.a, patients with refractory H. pylori infection. Gastric mucosal samples from the biobank of our research center were collected for 16S rRNA sequencing analysis and bacterial functions were predicted via PICRUSt.ResultsThere were significant differences between the H. pylori- positive group and the H. pylori-negative group in species diversity, gastric microbiota structure, and bacterial function. The beneficial Lactobacillus in the H. pylori-positive group were significantly enriched compared with those in the refractory H. pylori infection group. The bacterial interaction network diagram suggested that the microbiota interactions in the refractory H. pylori infection group decreased. The gastric microbiota of the refractory H. pylori infection group was enriched in the pathways of metabolism and infectious diseases (energy metabolism, bacterial secretion system, glutathione metabolism, protein folding and associated processing, sulphur metabolism, membrane and intracellular structural molecules, lipopolysaccharide biosynthesis, ubiquinone and other terpenoid-quinone biosynthesis, inorganic ion transport and metabolism, and metabolism of cofactors and vitamins) when compared with the H. pylori-positive group without treatment based on PICRUSt analysis.ConclusionSignificant alterations occurred in the gastric microbiota when eradication of H. pylori failed multiple times. A history of eradication of multiple H. pylori infections leads to an imbalance in the gastric mucosal microbiota to a certain extent, which was mainly reflected in the inhibition of the growth of beneficial Lactobacillus in the stomach. Patients with refractory H. pylori infection may be at a higher risk of developing gastric cancer than other H. pylori-positive patients.
Sleep duration and risk of cardio-cerebrovascular disease: A dose-response meta-analysis of cohort studies comprising 3.8 million participants
Authors: Huang Yi-Ming , Xia Wei , Ge Yi-Jun , Hou Jia-Hui , Tan Lan , Xu Wei , Tan Chen-Chen 
Published: September 2022

BackgroundThe effect of extreme sleep duration on the risk of cardiovascular and cerebrovascular diseases (CCDs) remains debatable. The pathology of CCDs is consistent in some respects (e.g., vascular factors), suggesting that there may be an overlapping range of sleep duration associated with a low risk of both diseases We aimed to quantify the dose-response relationship between sleep duration and CCDs.Study objectiveTo explore whether there is an optimal sleep duration (SD) in reducing the risk of CCDs.MethodsPubMed and EMBASE were searched until June 24, 2022 to include cohort studies that investigated the longitudinal relationships of SD with incident CCDs, including stroke and coronary heart disease (CHD). The robusterror meta-regression model (REMR model) was conducted to depict the dose-response relationships based on multivariate-adjusted risk estimates.ResultsA total of 71 cohorts with 3.8 million participants were included for meta-analysis, including 57 for cardiovascular diseases (CVD) and 29 for cerebrovascular disease. A significant U-shaped relationship was revealed of nighttime sleep duration with either cardiovascular or cerebrovascular disease. The nighttime sleep duration associated with a lower risk of CVD was situated within 4.3–10.3 h, with the risk hitting bottom at roughly 7.5 h per night (pnon–linearity &lt; 0.0001). Sleep duration associated with a lower risk of cerebrovascular diseases ranges from 5 to 9.7 h per night, with the inflection at 7.5 h per night (pnon–linearity = 0.05). Similar non-linear relationship exited in daily sleep duration and CCDs. Other subgroup analyses showed non-linear relationships close to the above results.ConclusionRational sleep duration (7.5 h/night) is associated with a reduced risk of cardio-cerebrovascular disease for adults.
Strategies for post–cardiac surgery acute kidney injury prevention: A network meta-analysis of randomized controlled trials
Authors: Chen Jia-Jin , Lee Tao Han , Kuo George , Huang Yen-Ta , Chen Pei-Rung , Chen Shao-Wei , Yang Huang-Yu , Hsu Hsiang-Hao , Hsiao Ching-Chung , Yang Chia-Hung , Lee Cheng-Chia , Chen Yung-Chang , Chang Chih-Hsiang 
Published: September 2022

ObjectsCardiac surgery is associated with acute kidney injury (AKI). However, the effects of various pharmacological and non-pharmacological strategies for AKI prevention have not been thoroughly investigated, and their effectiveness in preventing AKI-related adverse outcomes has not been systematically evaluated.MethodsStudies from PubMed, Embase, and Medline and registered trials from published through December 2021 that evaluated strategies for preventing post–cardiac surgery AKI were identified. The effectiveness of these strategies was assessed through a network meta-analysis (NMA). The secondary outcomes were prevention of dialysis-requiring AKI, mortality, intensive care unit (ICU) length of stay (LOS), and hospital LOS. The interventions were ranked using the P-score method. Confidence in the results of the NMA was assessed using the Confidence in NMA (CINeMA) framework.ResultsA total of 161 trials (involving 46,619 participants) and 53 strategies were identified. Eight pharmacological strategies {natriuretic peptides [odds ratio (OR): 0.30, 95% confidence interval (CI): 0.19–0.47], nitroprusside [OR: 0.29, 95% CI: 0.12–0.68], fenoldopam [OR: 0.36, 95% CI: 0.17–0.76], tolvaptan [OR: 0.35, 95% CI: 0.14–0.90], N-acetyl cysteine with carvedilol [OR: 0.37, 95% CI: 0.16–0.85], dexmedetomidine [OR: 0.49, 95% CI: 0.32–0.76;], levosimendan [OR: 0.56, 95% CI: 0.37–0.84], and erythropoietin [OR: 0.62, 95% CI: 0.41–0.94]} and one non-pharmacological intervention (remote ischemic preconditioning, OR: 0.76, 95% CI: 0.63–0.92) were associated with a lower incidence of post–cardiac surgery AKI with moderate to low confidence. Among these nine strategies, five (fenoldopam, erythropoietin, natriuretic peptides, levosimendan, and remote ischemic preconditioning) were associated with a shorter ICU LOS, and two (natriuretic peptides [OR: 0.30, 95% CI: 0.15–0.60] and levosimendan [OR: 0.68, 95% CI: 0.49–0.95]) were associated with a lower incidence of dialysis-requiring AKI. Natriuretic peptides were also associated with a lower risk of mortality (OR: 0.50, 95% CI: 0.29–0.86). The results of a sensitivity analysis support the robustness and effectiveness of natriuretic peptides and dexmedetomidine.ConclusionNine potentially effective strategies were identified. Natriuretic peptide therapy was the most effective pharmacological strategy, and remote ischemic preconditioning was the only effective non-pharmacological strategy. Preventive strategies might also help prevent AKI-related adverse outcomes. Additional studies are required to explore the optimal dosages and protocols for potentially effective AKI prevention strategies.