bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pharmacoeconomic rationale for switching patients with rheumatic diseases from original biologic disease-modifying antirheumatic drugs to biosimilars in context of the Russian healthcare system
Authors: Kulikov A. Yu , Serpik V. G. , Lila A. M. 
Published: June 2022

Objective: to analyze the pharmacoeconomic efficiency of biosimilars in context of national healthcare system.Material and methods. Based on the developed interactive pharmacoeconomic model, we made an analysis of the impact on the budget of treatment with biologic disease-modifying antirheumatic drugs (bDMARDs) and targeted synthetic disease-modifying antirheumatic drugs (tsDMARDs) in patients with rheumatoid arthritis (RA), spondyloarthritis (SpA), patients with psoriatic arthritis (PsA) were analyzed separately, within the framework of the study a cost-effectiveness analysis of bDMARD and tsDMARD therapy was performed to determine the preferred alternative in RA.Results and discussion. The performed pharmacoeconomic analysis confirmed the research hypothesis on the economic feasibility of transferring patients with rheumatic diseases (RA, PsA and SpA) receiving original bDMARDs to biosimilars in the context of Russian healthcare system. According to the cost analysis, biosimilars, except for infliximab, are characterized by comparatively less cost of a treatment course than the original drugs. The results of the budget impact analysis and cost analysis prove the economic feasibility of switching patients from original bDMARDs to biosimilars. At the same time, the parameters of the current and planned distributions entered in the calculations of the analysis of the impact on the budget, indicate the need of the professional community and patients for a wider use of innovative original bDMARDs that are under patent protection. At the same time, in the context of budgetary constraints, switching to biosimilars remains perhaps the only available strategy for increasing the coverage of patients with innovative drugs. It has been established that the etanercept biosimilar (ETC) Erelzy® has the lowest cost-effectiveness value. At the same time, ETC is characterized by the highest clinical efficiency, which makes it possible to determine the specified ETC biosimilar as strictly preferable from the point of view of the cost-effectiveness analysis.Conclusion. It can be assumed that in the absence of medical contraindications, switching of RA patients to ETC from other bDMARDs will be accompanied by better control of the disease, and the presence of biosimilars of ETCs, including the drug Erelzi®, which are among bDMARDs with the lowest cost of treatment course, will save funds, that can be rerouted to extend the coverage of patients with bDMARDs or increase the proportion of innovative bDMARDs.
Validation of the Indonesian Version of the Multidimensional Scale of Perceived Social Support (MSPSS): A Rasch Model Approach
Authors: Sulistiani Wiwik , Fajrianthi Fajrianthi , Kristiana Ika Febrian 
Published: June 2022

Scale adaptation in different cultures is needed to ensure that the scale measures the intended target. The Multidimensional Scale of Perceived Social Support (MSPSS) has been adopted in several countries, but no Indonesian language adaptation has been made so far. This study aims to test the construct validity of the Indonesian MSPSS that measures one’s level of social support. Rasch analysis was used to examine the psychometric properties of the scale. The subject in this study was 495 Indonesian marine cadets with an average age of 19.32 (41% Engineering, 52.7% Nautical, and 5.5% Electro). In terms of gender, 94.3% were male and 5.7% female. Findings from the Rasch analysis support the one-dimensionality of the 12-items MSPSS in measuring marine cadets’ level of social support. This finding differs from similar MSPSS studies that show the scale’s structure to be multidimensional. The 12-items MSPSS showed excellent internal consistency (person-item interaction index = .85) and fulfilled all the Rasch model requirements. No item misfit was detected from the MNSQ score (.5 < MNSQ < 1.5). Also, there was no item bias based on gender was detected from the scale (.0949 - .9687) > .05. Future studies are advised to test the scale with different samples to further confirm this study’s findings.
Significance of adding titanium dioxide nanoparticles to an existing distilled water conveying aluminum oxide and zinc oxide nanoparticles: Scrutinization of chemical reactive ternary-hybrid nanofluid due to bioconvection on a convectively heated surface
Authors: Revathi Gadamsetty , Animasaun Isaac Lare , Sajja Venkata Subrahmanyam , Jayachandra Babu Macherla , Boora Naresh , Raju Chakravarthula S. K. 
Published: June 2022

Abstract
With the emphasis on the properties of titanium dioxide nanoparticles and numerous applications of chemical reactive distilled water due to bioconvection in the industries, nothing is known about the significance of adding titanium dioxide nanoparticles to an existing distilled water conveying aluminum oxide and zinc oxide nanoparticles when viscous dissipation, heat source, and higher buoyancy forces and thermal radiation are substantial. The governing partial differential equations that model the motion of both transport phenomena mentioned earlier were transformed into ordinary differential equations using appropriate similarity transmutations and solved with bvp4c (MATLAB built-in function). Multiple linear regression (i.e., a statistical tool used to explain outcomes related to engineering parameters of interest) was adopted for a deep scrutinization and exploration. The outcome of the analysis suggests that the thermal radiation parameter can be used to control the heat transferred via convection in the fluid flow. It is detected that the magnetic field parameter and volume fraction of nanoparticle parameters are useful to reduce the shear stress near the surface. The heat source ameliorates the fluid temperature, and the concentration of the fluid decreases with the rise in the chemical reaction parameter. Worthy to conclude that the Peclet and Schmidt number escalates the density number of motile microorganisms.
Does Neoclassical Theory Exist in SMEs? Evidence from Central Java-Indonesia
Authors: Wahyudi Sugeng , Rita Maria Rio , Fuady Misbach 
Published: June 2022

Financial and non-financial aspects can influence company performance, not excluding small-medium enterprises (SMEs). This research examines the non-financial aspect, since studies in this area are still limited. This research strives to demonstrate the existence of the neoclassical theory in the relationship framework between the business aspect (real sector) and SME performance. This study, which was conducted on batik SMEs in Central Java Province-Indonesia, consisted of 265 samples. The data was obtained from surveys through distributing questionnaires and conducting interviews with batik SME entrepreneurs. The data analysis used a structural equation model (SEM). These study results documented that business prospects have direct and indirect effects on SME performance. The indirect influences are produced through entrepreneurial-oriented financial mediation. This finding reveals that the neoclassical theory will be more effective to improve company performance through entrepreneurial-oriented finance. The importance of the role of this mediating variable is shown from the total effect of the coefficient that is higher than the indirect effect or the direct effect of the coefficient.
Bioarchaeological Notes on the Commingled Human Remains Held in the Church of Saint Francis of Paola, Sant’Angelo di Brolo, Sicily, Italy
Authors: Kemežytė Aurelija , Piombino-Mascali Dario 
Published: June 2022

I this study, we examine human skeletal remains from the church of San Francis of Paola located in the small town of Sant’Angelo di Brolo, in the Italian region of Sicily. The preserved skeletal remains were temporarily transferred from their permanent resting place in the crypt for a macroscopic examination and evaluation. Various established methods were used to determine age at death, gender, stature, any evidence of disease(s) as well as the fact that there was a minimum of 15 individuals. The findings were then subdivided into different groups of pathologies and recorded as individual cases. Amongst which, dental issues and cases of trauma were most prevalent. Additional conditions such as joint disease, congenital, metabolic and multifactorial disorders were also identified. The prevalence of dental decay indicates that the group’s diet consisted largely of carbohydrates, and that their oral hygiene was poor. Furthermore, evidence of trauma and poor healing suggested that the town was isolated from the main medical centres of the island. Severe complications of traumas linked with a loss of movement and overall independence, as well as physical pain, must have had a significant impact on the lives of those affected.
The Impact of Religiosity on the Relationship between Corporate Social Responsibility (CSR) and Organizational Commitment
Authors: Sumunar Kurnia Indah , Jannah Lu'lu'ul , Anita Anita 
Published: June 2022

Non-financial performance variables such as corporate social responsibility (CSR) receive increased attention from stakeholders. This study examines whether CSR performance affects employees of Sharia financial institutions concerning organizational commitment and whether religiosity as a moderating variable strengthens or weakens that effect. Research on the role of employee performance toward CSR practices and the impact of those performances on employee behaviour is limited, especially in developing countries. In addition, the religiosity factor is still under consideration in terms of whether it affects employee performance. Based on information gathered from questionnaires distributed to employees of Sharia financial institutions in Indonesia, this study shows that CSR performance positively affects organizational commitment, and religiosity weakens the positive influence of CSR performance on organizational commitment. Employees feel CSR practices can affect their work performance because companies with good CSR practices could create a good reputation for their organization. AbstrakVariabel kinerja non-keuangan seperti tanggung jawab sosial perusahaan (CSR) mendapat perhatian yang besar dari para pemangku kepentingan. Penelitian ini menguji apakah kinerja CSR mempengaruhi karyawan lembaga keuangan syariah terhadap komitmen organisasi dan apakah religiusitas sebagai variable moderasi memperkuat atau memperlemah efek tersebut. Penelitian tentang peran kinerja karyawan terhadap praktik CSR dan dampak sikap tersebut terhadap perilaku karyawan masih terbatas, terutama dalam konteks negara berkembang. Selain itu, faktor religiositas masih dalam pertimbangan apakah berpengaruh terhadap kinerja karyawan. Berdasarkan informasi yang dikumpulkan dari kuesioner yang dibagikan kepada karyawan lembaga keuangan syariah di Indonesia, penelitian ini menunjukkan bahwa kinerja CSR berpengaruh positif terhadap komitmen organisasi, dan religiusitas memperlemah pengaruh positif kinerja CSR terhadap komitmen organisasi. Karyawan merasa praktik CSR dapat mempengaruhi kinerja di tempat kerja karena perusahaan dengan praktik CSR yang baik dapat menciptakan reputasi yang baik bagi organisasi.
Akad Murokab on the DSN-MUI Fatwa and its Effect on Islamic Bank Funding Products
Authors: Fatah Dede Abdul , Muchtasib Ach. Bakhrul , Rahmatullah Indra , Soydan Mustafa Zafer 
Published: June 2022

The study determines whether Islamic bank management understands hybrid contracts in the DSN-MUI funding fatwa and its influence on developing funding products in Islamic banks. The type of research used is normative juridical to examine the application of Islamic legal rules both at the methodological level (uṣul fiqh) and fiqh rules and at the product level (fiqh). The primary data of this study comes from the DSN-MUI fatwa and interviews to explore the understanding of Islamic bank management towards hybrid contracts in the DSN-MUI funding fatwa. This study indicates that from eight fatwas on DSN- MUI funding products, only fatwa No. 86 and 87 containing hybrid contracts. There are several theoretical frameworks, standards, and limitations (ḍawābiṭ) that the DSN-MUI has determined. The study also shows that the management of Islamic banks, generally, has understood the theoretical framework, standards and limitations of hybrid contracts on Islamic bank funding products only in textual concept. The textual understanding can increase the portfolio of funding products. This can be evidenced by the increasing portfolio of muḍārabah savings and income smoothing programs at Islamic banks. Abstrak Penelitian ini mengkaji apakah manajemen bank syariah memahami kontrak hybrid dalam fatwa pendanaan DSN-MUI dan pengaruhnya terhadap pengembangan produk pendanaan di bank syariah. Metode yuridis normatif digunakan untuk mengkaji penerapan kaidah hukum Islam baik pada tataran metodologis (ushul fiqh) dan kaidah fikih maupun tataran produk (fikih). Data utama penelitian ini bersumber dari fatwa DSN-MUI dan wawancara untuk menggali pemahaman manajemen bank syariah terhadap multi akad pada fatwa pendanaan DSN-MUI. Penelitian ini menunjukan bahwa dari 8 fatwa produk pendanaan DSN-MUI hanya fatwa No. 86 dan 87 yang terdapat multi akad dengan beberapa kerangka teori, standar, dan batasan-batasan (ḍawābiṭ) yang telah ditentukan oleh DSN-MUI agar tidak terjeurumus pada multi akad yang dilarang. Penelitian ini juga menunjukan bahwa manajemen bank Syariah secara umum sudah memahami kerangka teori, standar dan batasan-batasan multi akad pada produk pendanaan bank Syariah pada konsep tekstual di mana dapat mempengaruhi peningkatan portofolio produk penadanaan. Hal ini dapat dibuktikan dengan meningkatnya portofolio tabungan mudharabah dan program income smoothing di bank Syariah.
Hand-Gesture Detection Using Principal Component Analysis (PCA) and Adaptive Neuro-Fuzzy Inference System (ANFIS)
Authors: Setianingrum Anif Hanifa , Fauzia Arifa , Rahman Dzul Fadli 
Published: June 2022

Sign language is a non-verbal language that Deaf persons exclusively count on to connect with their social environment.The problem that occurs in two-way communication using sign language is a misunderstanding when learning new terms that need to be taught to deaf and mute people. To minimize these misunderstandings, a system is needed that can assist in correcting hand gestures so that there is no misinterpretation in teaching new terms. Several optimality properties of PCA have been identified namely: variance of extracted features is maximized; the extracted features are uncorrelated; finds best linear approximation in the mean-square sense and maximizes information contained in the extracted feature. The classification uses the Adaptive Neuro-Fuzzy Inference System (ANFIS) method. From the results of experiments with different image size variables, the largest accuracy was obtained with an image size of 449x449 of 76.20%. While the lowest accuracy of 52.38% is obtained through scenarios with image sizes of 57x57 and 45x45. Therefore, differences in the use of image sizes have an influence on the accuracy of hand signal prediction. The smaller the size given, the smaller the accuracy obtained. This is indicated by the decreasing accuracy value when given a smaller size in the four scenarios that have been studied.
Health Impairments in Children and Adolescents After Hospitalization for Acute COVID-19 or MIS-C
Authors: Maddux Aline B. , Berbert Laura , Young Cameron C. , Feldstein Leora R. , Zambrano Laura D. , Kucukak Suden , Newhams Margaret M. , Miller Kristen , FitzGerald Madyson M. , He Jie , Halasa Natasha B. , Cvijanovich Natalie Z. , Loftis Laura L. , Walker Tracie C. , Schwartz Stephanie P. , Gertz Shira J. , Tarquinio Keiko M. , Fitzgerald Julie C. , Kong Michele , Schuster Jennifer E. , Mack Elizabeth H. , Hobbs Charlotte V. , Rowan Courtney M. , Staat Mary A. , Zinter Matt S. , Irby Katherine , Crandall Hillary , Flori Heidi , Cullimore Melissa L. , Nofziger Ryan A. , Shein Steven L. , Gaspers Mary Glas , Hume Janet R. , Levy Emily R. , Chen Sabrina R. , Patel Manish M. , Tenforde Mark W. , Weller Edie , Campbell Angela P. , Randolph Adrienne G. ,   for the Overcoming COVID-19 Investigators
Published: June 2022

OBJECTIVES
To evaluate risk factors for postdischarge sequelae in children and adolescents hospitalized for acute coronavirus disease 2019 (COVID-19) or multisystem inflammatory syndrome in children (MIS-C).

METHODS
Multicenter prospective cohort study conducted in 25 United States pediatric hospitals. Patients &lt;21-years-old, hospitalized May 2020 to May 2021 for acute COVID-19 or MIS-C with follow-up 2 to 4 months after admission. We assessed readmissions, persistent symptoms or activity impairment, and new morbidities. Multivariable regression was used to calculate adjusted risk ratios (aRR) and 95% confidence intervals (CI).

RESULTS
Of 358 eligible patients, 2 to 4 month survey data were available for 119 of 155 (76.8%) with acute COVID-19 and 160 of 203 (78.8%) with MIS-C. Thirteen (11%) patients with acute COVID-19 and 12 (8%) with MIS-C had a readmission. Thirty-two (26.9%) patients with acute COVID-19 had persistent symptoms (22.7%) or activity impairment (14.3%) and 48 (30.0%) with MIS-C had persistent symptoms (20.0%) or activity impairment (21.3%). For patients with acute COVID-19, persistent symptoms (aRR, 1.29 [95% CI, 1.04–1.59]) and activity impairment (aRR, 1.37 [95% CI, 1.06–1.78]) were associated with more organ systems involved. Patients with MIS-C and pre-existing respiratory conditions more frequently had persistent symptoms (aRR, 3.09 [95% CI, 1.55–6.14]) and those with obesity more frequently had activity impairment (aRR, 2.52 [95% CI, 1.35–4.69]). New morbidities were infrequent (9% COVID-19, 1% MIS-C).

CONCLUSIONS
Over 1 in 4 children hospitalized with acute COVID-19 or MIS-C experienced persistent symptoms or activity impairment for at least 2 months. Patients with MIS-C and respiratory conditions or obesity are at higher risk of prolonged recovery.
Штучний інтелект у муніципальному управлінні: вектори розвитку
Authors: Квітка Сергій , Новіченко Надія , Бардах Олександр 
Published: June 2022

Штучний інтелект, враховуючи сучасні тренди цифрової трансформації, є однією з найбільш актуальних і затребуваних цифрових технологій, яка застосовується для вирішення широкого комплексу завдань, пов'язаних з практикою публічного управління та надання муніципальних послуг. Штучний інтелект стає все більш затребуваним як в державному управлінні, так і в практиці організації роботи органів місцевого самоврядування, при розробці і реалізації планів ефективного використання муніципальних ресурсів.
Мета дослідження - визначити основні вектори впровадження штучного інтелекту в практику діяльності органів муніципального управління на основі аналізу закордонного досвіду цифрових перетворень.
Методи дослідження. Для дослідження досвіду впровадження цифрової технології штучного інтелекту в країнах, що є лідерами цифровізації публічного управління та розробки GovTech, використано порівняльний аналіз. Структурно-функціональний метод застосовано для визначення основних векторів використання штучного інтелекту в муніципальному управлінні.
Результати дослідження показали широку світову практику використання штучного інтелекту у сфері муніципального управління та описали нові можливості для впровадження штучного інтелекту у практику місцевого самоврядування в Україні.
Висновки. Цифрове перетворення управління на основі штучного інтелекту може бути визнано таким тільки в результаті повномасштабного оцифрування усього масиву даних, які зібрано і що використовуються в публічному управлінні, автоматизації даного процесу і радикальному підвищенні ступеня обробки даних за допомогою технологій штучного інтелекту, які приведуть до значного підвищення якості роботи як муніципальних, так і державних відомств.
Contradictions of Realism and Liberalism on Interstate Relations: in the Case of Russo-Georgian War
Authors: Джахангірлі Джахангір 
Published: June 2022

In the article, where contradictions of Realism and Liberalism on interstate relations are researched, approaches over the case of Russo-Georgian War are compared and argumentations of both approaches are presented. In comparison to Liberalism, which claims Russia intervened Georgia for the sake of protecting equality of individual rights, Realism, which guess Russo-Georgian War as a part of maintaining of continental interests of Russia is defended by author. After giving explanations to theories and providing facts about 2008 Russo-Georgian War theme of research is switched to comparison part of the article. The comparison is established over main theoretical nuances and multi-argumented claims of both views. According to findings of the research obtained from comparative analysis methods, Russo-Georgian War is a “product” of the policy ‘‘divide and rule’’ implemented by Russia in the post-soviet republics.
The research engages the results of war and harmony; therefore, it has useful significance. In any case, the adjustment by and by has created extensive disarray with respect to who is included as the chief on-screen characters; since there are various types of state and non-states entertainers. These on-screen characters lead to a wide scope of stakes, assorted objectives, complex methods of communication, and various organizations inside which the entertainers take activities. The old show which was the principal supporter of the verbalization of the meaning of universal relations was the differentiation between common society and the state. This qualification discovered money in the eighteenth century when it depicted two particular circles of human association and practice; the rising of the general public of individuals described by agreement and market relations, and an express whose chief capacity was to keep up interior harmony and outer protection. In the present age, in any case, the state and common society are interlaced that the global connection idea has gotten absolutely expository.