bluuebunny/crossref_metadata_2025_split huggingface dataset:
Avaliação de Fatores que Influenciam na Implantação de Programas de Gestão de Riscos e de Integridade da Marinha do Brasil
Authors: Sabá Cavalcante Karen Fernanda , Neves dos Santos João Alberto , Von Raschendorfer Érica , Lyrio Eduardo Felicíssimo 
Published: February 2025

Este estudo teve por objetivo avaliar os fatores que mais influenciam a implantação de Programas de Gestão de Riscos (PGR) e de Integridade (PGI) com vistas a identificar os principais obstáculos e as estratégias para enfrentar a resistência às mudanças. Para isso, foi conduzida uma Revisão Sistemática de Literatura, seguida de análise de conteúdo e categorização, o que possibilitou o desenvolvimento e aplicação do questionário com 39 assertivas sobre a implantação dos Programas, sendo obtidas 74 respostas válidas. Devido às diferenças identificadas na aplicação do Teste Qui-quadrado nas respostas dos três grupos de respondentes, o estudo quantitativo, por meio o Teste t, foi feito utilizando as 48 respostas válidas dos membros que trabalham na operação do PGR. Apesar do pequeno tamanho da amostra, a análise dos resultados sugere que a Marinha do Brasil esteja na fase inicial da implantação dos PGI e PGR. Os resultados sugerem que a Capacitação é um obstáculo à implantação do PGR, o que pode dificultar a governança do Programa. Os resultados também indicam a dependência do PGI em relação à implantação do PGR. Além disso, os fatores relacionados à atuação das lideranças para apoiar a integridade, para reduzir as falhas na comunicação interna e as barreiras à transparência e reduzir as falhas na identificação, análise e execução das respostas aos riscos sugerem que esses fatores estejam ainda pouco consolidados, talvez devido a características próprias do ambiente militar onde é fundamental o sigilo e a segurança. A pesquisa confirmou ainda que as estratégias para reduzir a resistência às mudanças relacionadas a ter uma comunicação clara e constante, ao envolvimento e participação dos militares e civis, a praticar reconhecimento e recompensa e, principalmente, a contar com uma liderança que dá o exemplo são essenciais para implementar mudanças com base no PGR e PGI.
Development of a 2D hydrodynamic model for flood assessment and alert system for the lower Narmada basin, Gujarat (India)
Authors: Bhargav Anurag , Suresh R. , Tiwari Mukesh K. , Trambadia Nevil K. , Chandra Ravish , Nirala Sanjay Kumar 
Published: February 2025

ABSTRACT

The study develops a 2D hydrodynamic model using HEC-RAS to assess flood hazards and generate inundation maps for the lower Narmada basin in Gujarat, India. The model effectively simulates flood dynamics by integrating data, i.e. digital elevation models, stream gauge data, and land use and land cover information. Results indicate strong model performance, with R² and RMSE values of 0.92 and 0.12 for calibration and 0.77 and 0.08 for validation. Approximately 326.45 km² of the basin is severely inundated during major flood events, with agriculture being most affected. The model's outputs, including depth maps, velocity maps, and water arrival time predictions, provide critical insights for flood management. Floodwaters take 110 h to reach nearby areas and 361 h to reach validation points from upstream dam releases, offering an 8-h window to alert residents of potential overflow conditions. This information is vital for early warning systems and evacuation planning.
Correlation of oxidative stress enzymes and histological alteration in the gastrointestinal tract of Clarias gariepinus induced with alpha olefin sulfonate
Authors: Ikpesu Thomas , Odagwe Alexander Amechi 
Published: February 2025

ABSTRACT

This study examined antioxidant system responses and gastrointestinal pathological changes related to alpha olefin sulfonate (α-OS) toxicity in generated oxidative stress. Clarias gariepinus, self-bred fish, including the control, were exposed to α-OS concentrations observed in the field (0.05, 0.10, 0.15, and 0.20 mg/l) for 30 days. Sigma-Aldrich test kits were used to assess reduced glutathione S-transferase (GST) spectrophotometrically, while abnormal changes or damage in the gastrointestinal tract (GIT) were examined under a microscope. In plasma, α-OS exposure increased GST activities by 73%, varying with dose and duration. Glutathione (GSH) activity decreased by 26% but had few impacts. Increasing α-OS concentration and exposure duration led to histopathologic damage in the GIT, while the control fish had a normal GIT architecture. Fish absorb surfactants easily through their skin and gills, and blood circulates them to their organs. Fish contamination lowers human resistance by altering numerous enzymes through the food chain. When other contaminants are present in high amounts, the combined toxicity damages biota more than either pollutant alone. Any detergent contamination in coastal waters should be addressed seriously because the organisms that are low on the food chain and other sensitive ones will be eliminated even at low concentrations.
Direct Antiviral Effects of Baicalin and Baicalein against SARS-COV-2: A Systematic Review
Authors: Ahmadi Mehdi , Shahbahrami Ramin , Esfehani Mohammad Amin Nooranian , Hosseini Seyede Marzieh , Khajeh Fatemeh , Raziabad Reza Hazrati , Nezhadi Javad , Ghanati Kiandokht 
Published: February 2025

Background:
The search for effective antiviral therapies against the Coronaviridae
family, particularly SARS-CoV-2, remains a critical priority. Baicalin and baicalein, natural flavonoid
compounds, have shown promising antiviral activity against SARS-CoV-2 in various
experimental studies.

Methods:
This systematic review, encompassing 25 total articles, analyzed the direct antiviral
effects of these compounds against SARS-CoV-2, focusing on their inhibitory activity against
key viral proteins.

Results:
Baicalin and baicalein exhibit antiviral activity against SARS-CoV-2, primarily by targeting
the main protease (3CLpro) and, to a lesser extent, other viral proteins like RdRp, PLpro,
and the spike protein. Baicalein consistently demonstrates superior inhibitory activity with lower
IC50 values and higher selectivity indices compared to baicalin. While the article highlights
promising antiviral activity, it also notes that baicalein might be a promiscuous Mpro inhibitor
and its efficacy may be influenced by the presence of reducing agents like DDT. While baicalein
shows potential as a promising antiviral agent, further research is necessary to confirm its
in-vivo efficacy, optimize its pharmacokinetic properties, and fully understand its mechanisms
of action.

Conclusion:
Further investigation into the potential for off-target effects, particularly the observed
renal toxicity, is also warranted.
Intestinal Lipoma Acting as a Lead Point of Intussusception: A Case Series
Authors: Jian Mei-Ying , Luo Xiao-Yan , Luo Xiu-Qin , Jin Ai-Fang , Luo Zhe-Huang 
Published: February 2025

Background:
Lipomas represent a rare benign etiology of intussusception in adults, affecting both the small intestine and the colon. Diagnosing intussusception
in adults can be challenging, and there are no reports on the use of positron emission tomography/CT (PET/CT) in the diagnosis of lipoma-induced
intussusception. This study aimed to preliminarily explore the potential diagnostic utility of 18F-FDG PET/CT in the diagnosis of intussusception
caused by lipomas.

Methods:
We conducted a retrospective review of the clinical characteristics and imaging findings of three patients diagnosed with lipoma-induced
intussusception using 18F-FDG PET/CT from 2019 to 2023 at our hospital.

Results:
The three cases presented with diverse clinical presentations and were diagnosed based on PET/CT imaging. Surgical confirmation was obtained in
two cases. Lipomas were identified in both the small intestine and the colon, with one case displaying increased metabolic activity on FDG uptake,
suggesting a possible link between FDG uptake and clinical severity.

Conclusion:
Lipoma is a benign cause of intussusception that can occur in both the small intestine and the colon. The symptoms of adult intussusception are
often atypical and variable. Imaging modalities, particularly PET/CT, are instrumental in diagnosing intussusception due to lipomas, differentiating
between benign and malignant causes, and assessing the severity to inform treatment strategies.
Mycophenolic Acid Derivatives from Vietnamese Marine Sponge-derived Penicillium sp. 1901NT-2.53.1 Strain and their Antiproliferative Activity
Authors: Khmel Olga O. , Trinh Phan Thi Hoai , Ngoc Ngo Thi Duy , Chingizova Ekaterina A. , Drozdov Konstantin A. , Popov Roman S. , Van Tran Thi Thanh , Khanh Huynh Hoang Nhu , Duc Thinh Pham , Yurchenko Ekaterina A. , Yurchenko Anton N. 
Published: February 2025

Background:
Marine sponges and sponge-associated fungi are rich sources of bioactive
compounds with pharmacological potential. However, the secondary metabolites of Vietnamese
marine sponge-derived fungi have been poorly studied.

Objective:
The aim of this study was to investigate the low-molecular-weight compounds in the
extract of Penicillium sp. 1901NT-2.53.1 fungus isolated from the Vietnamese marine sponge
Cinachyrella sp., and the antiproliferative activity of the isolated compounds.

Methods:
The structures of isolated compounds were elucidated using spectroscopic methods.
The cell viability effects of the compounds were evaluated using MTT assay. Molecular docking
was performed using SwissDock.

Results:
UPLC-MS data suggested the presence of beauvericin, citreorosein, benzopyran and
chlorotetracycline derivatives, 2-chloro-1,3,8-trihydroxy-6-(hydroxymethyl)anthracene-9,10-
dione and ergosterol peroxide in the fungal extract. Chromatographic separation of the extract
resulted in the isolation of three derivatives of mycophenolic acid (MPA), namely penicacids G
and K and 4-hydroxy-MPA. Penicacid K was isolated from a natural source for the first time.
Penicacid G inhibited the viability of human normal HaCaT keratinocytes with IC50 of 88.3 μM
and 72.9 μM for 24 h and 48 h of treatment, respectively. Moreover, penicacid G arrested the proliferation
of HaCaT keratinocytes. Both penicacids K and G can interact with the active site of
IMPDH2, similar to other derivatives of MPA; however, the differences in their structures are
important.

Conclusion:
Due to the selective action on cancer cells and good druggability, penicacid G may
be interesting as an antiproliferative anticancer compound.
LC-MS Characterization and Antiviral Proficiency of Fish Mint (Houttuynia cordata) Aqueous Extract Against EV-A71
Authors: Hamidi Munira , Ong Kien Chai , Wong Kum Thong , Yap Yeannie Hui Yeng , Tan Soon Hao 
Published: February 2025

Background and Objectives:
Enterovirus A71 (EV-A71), is a hand, foot and mouth disease
that has become one of the major health concerns in the Asia-Pacific region. Prior studies
have reported that Houttuynia cordata (H. cordata) extract may possess antiviral activity against
EV-A71. In this study, the chemical composition of H. cordata aqueous extract and its anti-
EV-A71 properties were studied.

Materials and Methods:
Anti-EV-A71 properties were studied according to different viral infection
stages using cell survivability and viral titration assay repeatability against different EV-A71
sub-genotypes and stability in human saliva and hydrochloric acid was also tested. The total carbohydrate
and protein content of the extract were estimated and active compounds were screened using
LC-MS analysis.

Results:
The H. cordata extract exhibits significant inhibition against EV-A71 at a concentration
of 1 mg/ml with minimal cytotoxicity. This antiviral effect is robust and resilient even in the presence
of human salivary enzymes and an acidic environment. Intriguingly, our study indicates that
the SCARB2 receptor does not seem to play a role in mediating the anti-EV-A71 activity. These
promising results extend to various sub-genotypes of EV-A71. The total carbohydrate and protein
content in the extract was 521.13 μg/ml and 21 μg/ml, respectively. LC-MS analysis unveiled the
presence of 4 known and 16 unknown compounds, expanding our understanding of its composition.

Conclusion:
These results underscore the potential of H. cordata aqueous extract and its constituents
as promising candidates for the development of novel antiviral agents. Furthermore, our
findings contribute to the broader field of antiviral research and highlight the potential of traditional
Chinese medicine in combating viral infections.
Quantification of [11C]ABP688 Binding to mGluR5 in Human Brain using Cerebellum as Reference Region: Biological Interpretation and Limitations
Authors: Milella Michele S. , Minuzzi Luciano , Benkelfat Chawki , Soucy Jean-Paul , Kirlow Alexandre , Schirrmacher Esther , Angle Mark , Verhaeghe Jeroen A.J. , Massarweh Gassan , Reader Andrew J. , Aliaga Antonio , Peixoto-Santos Jose Eduardo , Guiot Marie-Christine , Kobayashi Eliane , Rosa-Neto Pedro , Leyton Marco 
Published: February 2025

Introduction:
In vitro data from primates provide conflicting evidence about the suitability
of the cerebellum as a reference region for quantifying type 5 metabotropic glutamate receptor
(mGluR5) binding parameters with positron emission tomography (PET).

Methods:
We first measured mGluR5 density in postmortem human cerebellum using [3H]ABP688
autoradiography (n=5) and immunohistochemistry (n=6). Next, in vivo experiments were conducted in
healthy volunteers (n=6) using a high-resolution PET scanner (HRRT) to compare [11C]ABP688 binding
potential (BPND) values obtained with reference tissue methods and the two-tissue compartment
model vs. metabolite-corrected arterial input function.

Results:
The postmortem data showed that, relative to the hippocampus, the cerebellum had 35% less
mGluR5 immunoreactivity and 94% fewer [3H]ABP688 binding sites. In vivo brain regional
[11C]ABP688 BPND values using the cerebellum as a reference region were highly correlated with
BPND values and distribution volumes derived by arterial input methods (R2 > 0.9).

Conclusion:
The scarce availability of cerebellar allosteric binding sites at autoradiography, compared
to immunohistochemistry results, might reflect the presence of distinct mGluR5 isoforms or conformational
state. Together with our PET data, these data support the proposition that [11C]ABP688 BPND
using the cerebellum as a reference region provides accurate quantification of mGluR5 allosteric binding
in vivo. Studies relying on this method could, therefore, be used in clinical populations, providing
that stronger initial assumptions are met.
Analysis of Causative Factors, Clinical Course, and Diagnosis of Secretory Otitis Media in Adults
Authors: Orishchak Ostap , Orishchak Diana , Vasyliuk Nataliia 
Published: February 2025

Abstract. The paper assessed and systematized the primary causative factors, clinical progression, and diagnosis of secretory otitis media in adults through bibliographic and structural-logical analyses. The global significance of this issue has been assessed based on international and national research.
The study aimed to analyze the primary causative factors, clinical course, and diagnosis of secretory otitis media in adults, as well as their significance in selecting the most effective treatment methods.
Material and Methods. Bibliographic and structural-logical analyses were used to investigate secretory otitis media in adults as a medical and social issue.
Results. Recent studies have challenged previous beliefs of a single etiology for secretory otitis media, identifying multiple potential causes and variations in disease progression influenced by their combination and predominance.
Conclusions. The analysis revealed that, despite the wealth of data available on the etiology, pathogenesis, diagnosis, and treatment of SOM, it remains one of the leading causes of hearing loss in adults. Ongoing research into the causative factors and their systematization will enable improved functional outcomes and reduced recurrence rates by applying pathogenetically-based treatments.
Keywords: Secretory Otitis Media; Etiology; Pathogenesis; Diagnosis; Hearing Los
Management of Fluid Therapy in Acute Alcoholic Pancreatitis
Authors: Feshovets Nazar , Pyptiuk Oleksandr 
Published: February 2025

Abstract. Acute alcoholic pancreatitis (AAP) represents a significant cause of hospitalizations in surgical departments, with severe cases leading to multi-organ failure and high mortality rates, up to 30%. Effective management of AAP requires accurate patient condition assessment, which directly influences treatment strategies, including fluid resuscitation, pain relief, nutritional support, and antibiotic use. A key factor in AAP outcomes is the development of hypovolemia, caused by fluid loss into the peritoneal and retroperitoneal spaces, exacerbating systemic and local hypoperfusion, tissue ischemia, and pancreatic necrosis. Proper fluid therapy is essential to prevent both hypovolemia-related complications and fluid overload, which may lead to pleural effusion, cerebral edema, and cardiovascular dysfunction. Current guidelines for fluid therapy in AAP focus on maintaining specific physiological parameters such as mean arterial pressure, heart rate, central venous pressure, urine output, and hematocrit levels. However, the use of non-invasive methods like bioimpedance analysis, which measures tissue resistance to determine fluid distribution, may offer more precise insights into the patient's fluid status, enabling better management of infusion therapy.
The aim to optimize fluid management in patients with moderate to severe AAP and reduce infectious complications through the use of bioimpedance analysis.
Materials and methods. A total of 110 patients were enrolled, including 101 men and 9 women. The patients were divided into two groups: one treated with standard fluid therapy using Ringer's lactate solution and the other receiving Sterofundin ISO solution, with infusion volumes adjusted according to bioimpedance measurements. Laboratory tests, including procalcitonin levels and the Limulus amebocyte lysate (LAL) test, were used to monitor inflammatory markers and endotoxin levels, while bioimpedance measurements were conducted on days 1, 3, 5, 8, 11, and 14 to dynamically assess fluid balance.
The results showed that patients treated with Sterofundin ISO and bioimpedance-guided fluid management experienced a significant reduction in extracellular fluid volume deviations and infectious complications compared to those receiving standard treatment. In the second group, the incidence of infectious complications in patients with moderate AAP decreased from 35.9% to 21.62%, and in severe cases, from 81.3% to 44.45%..
Key words: acute alcoholic pancreatitis, LAL-test, bioimpedance measurement, infusion, infectious complications
Evaluation of the Quality of Delirium Website Content for Patient and Family Education: Cross-Sectional Study
Authors: Krewulak Karla , Strayer Kathryn , Jaworska Natalia , Spence Krista , Foster Nadine , Kupsch Scotty , Sauro Khara , Fiest Kirsten M 
Published: February 2025

Background
Patients and families who have experienced delirium may seek information about delirium online, but the quality and reliability of online delirium-related websites are unknown.

Objective
This study aimed to identify and evaluate online delirium-related websites that could be used for patient and family education.

Methods
We searched Microsoft Bing, Google, and Yahoo using the keywords “delirium” and the misspelled “delerium” to identify delirium-related websites created to inform patients, families, and members of the public about delirium. The quality of identified delirium-related website content was evaluated by 2 authors using the validated DISCERN tool and the JAMA (Journal of the American Medical Association) benchmark criteria. Readability was assessed with the Simple Measure of Gobbledygook, the Flesch Reading Ease score, and the Flesch Kincaid grade level. Each piece of website content was assessed for its delirium-related information using a checklist of items co-designed by a working group, which included patients, families, researchers, and clinicians.

Results
We identified 106 websites targeted toward patients and families, with most hospital-affiliated (21/106, 20%) from commercial websites (20/106, 19%), government-affiliated organizations (19/106, 18%), or from a foundation or advocacy group (16/106, 15%). The median time since the last content update was 3 (IQR 2-5) years. Most websites’ content (101/106, 95%) was written at a reading level higher than the recommended grade 6 level. The median DISCERN total score was 42 (IQR 33-50), with scores ranging from 20 (very poor quality) to 78 (excellent quality). The median delirium-related content score was 8 (IQR 6-9), with scores ranging from 1 to 12. Many websites lacked information on the short- and long-term outcomes of delirium as well as how common it is. The median JAMA benchmark score was 1 (IQR 1-3), indicating the quality of the websites’ content had poor transparency.

Conclusions
We identified high-quality websites that could be used to educate patients, families, or the public about delirium. While most delirium-related website content generally meets quality standards based on DISCERN and JAMA benchmark criteria, high scores do not always ensure patient and family-friendliness. Many of the top-rated delirium content were text-heavy and complex in layout, which could be overwhelming for users seeking clear, concise information. Future efforts should prioritize the development of websites with patients and families, considering usability, accessibility, and cultural relevance to ensure they are truly effective for delirium education.
Guerra à Paz:
Authors: Menescal Gastão 
Published: February 2025

O presente trabalho tem por objetivo a análise das relações bilaterais entre o Reino da Itália e a República do Brasil durante os anos da Primeira Guerra Mundial, contemplando as bases destes vínculos diplomáticos e seus impactos para os dois países. O artigo fará uso de pesquisa bibliográfica tendo como referências artigos e livros sobre o tema, buscando examinar acuradamente as fontes históricas de língua italiana e portuguesa. É compreensível que o fenômeno da Grande Guerra resultou no desmantelamento da ordem internacional herdada do Congresso de Viena. O conflito afetou profundamente as relações entre os componentes do sistema, impulsionando movimentos migratórios, alianças imprevistas e novas controvérsias internacionais. Através da pesquisa documental, conclui-se que a colaboração no contexto da Tríplice Entente foi propulsora dos laços entre Roma e o Rio de Janeiro, proporcionado um grandioso salto qualitativo em seus contatos bilaterais com consequências expressivas para o longo e inquieto século XX.