bluuebunny/crossref_metadata_2025_split huggingface dataset:
Credit and Poverty in Early Modern Venice
Authors: Pompermaier Matteo 
Published: March 2022

Abstract
In early modern Venice, wine and money were intrinsically linked through the pawnbroking service that innkeepers and bastioneri, the managers of wine warehouses (bastioni), offered their customers. The loans that they supplied were generally small, officially interest-free, and frequent. Moreover, at least one-third of each was paid in wine, at that time considered a staple. Hence, innkeepers and bastioneri were central figures in Venice’s urban context, especially for the poor. Those individuals, usually considered “voiceless” in history were, in fact, the main actors in what might be termed a “handkerchief” economy, named for one of its most pawned items.
Bible Translation as Contextual Theology
Authors: Hwang Jerry 
Published: March 2022

Abstract
Lamin Sanneh has influentially observed that translating the Bible is always a seminal act of doing contextual theology. While this has been well demonstrated for the African context, it has rarely been explored for the Asian context. This article examines the Chinese Union Version (cuv) Bible of 1919, a venerated translation that is simply ‘the Bible’ for Chinese Christians. As a result of being mainly the work of Western translators, however, the cuv has lexicalised and sacralised a distinctly western and Protestant understanding of sin as ‘crime’ which has become conventional usage among Chinese Christians. Even so, the linguistic potential for defamiliarising the concept of sin and recasting it in a more contextual manner for Chinese readers already lies within the cuv. Greater attention to the cuv’s concreteness in rendering Old Testament sin-idioms, as opposed to the standard Protestant abstractions, would therefore refresh the voice of Chinese Christianity.
Wooden Roofing: Split Shingles versus Sawn Boards
Authors: Grabner Michael , Nemestothy Sebastian , Wächter Elisabeth 
Published: March 2022

Abstract
Wooden shingles have been known in Europe and other regions worldwide for several thousands of years. They are usually split, and according to handicraft rules, as well as historical literature, a split surface has many advantages. It is more flexible, more elastic, stronger, and less exposed to cupping than a sawn surface because no fibers have been cut. It also follows wood rays; it is more durable than a sawn surface because cut fibers absorb more moisture, creating good conditions for fungal growth. However, because sawing is the main procedure for dividing logs into timber, sawn boards are currently used for roofing. The short life span of such roofing has often been discussed by craftsmen. In this study, a 37-year-old roofing was evaluated to determine the important parameters of high-durability sawn boards. Results showed that the presence of juvenile wood, fiber deviations, and knots reduced the durability of these boards. Therefore, sawn boards of the same wood quality as split shingles may have the same durability.
NORA3: A Nonhydrostatic High-Resolution Hindcast of the North Sea, the Norwegian Sea, and the Barents Sea
Authors: Haakenstad Hilde , Breivik Øyvind , Furevik Birgitte R. , Reistad Magnar , Bohlinger Patrik , Aarnes Ole Johan 
Published: March 2022

AbstractThe 3-km Norwegian Reanalysis (NORA3) is a 15-yr mesoscale-permitting atmospheric hindcast of the North Sea, the Norwegian Sea, and the Barents Sea. With a horizontal resolution of 3 km, the nonhydrostatic numerical weather prediction model HARMONIE–AROME runs explicitly resolved deep convection and yields hindcast fields that realistically downscale the ERA5 reanalysis. The wind field is much improved relative to its host analysis, in particular in mountainous areas and along the improved grid-resolving coastlines. NORA3 also performs much better than the earlier hydrostatic 10-km Norwegian Hindcast Archive (NORA10) in complex terrain. NORA3 recreates the detailed structures of mesoscale cyclones with sharp gradients in wind and with clear frontal structures, which are particularly important when modeling polar lows. In extratropical windstorms, NORA3 exhibits significantly higher maximum wind speeds and compares much better to observed maximum wind than do NORA10 and ERA5. The activity of the model is much more realistic than that of NORA10 and ERA5, both over the ocean and in complex terrain.
The effects of task-oriented mental practice on upper limb function and coordination in chronic stroke patients—Randomized controlled trial design
Authors: Park JuHyung 
Published: March 2022

ObjectiveThis study is a randomized experimental design study conducted to investigate the effect of task-oriented mental practice (TOMP) on upper limb function and coordination in chronic stroke patients.MethodsA total of 34 chronic stroke patients participated in this study and were randomly divided into an experimental group (EG) of 17 patients (TOMP) and a control group (CG) of 17 patients (task-oriented training). To measure the subject’s upper extremity function and coordination, the results of Fugl-Meyer assessment (FMA) of motor function (U/E) and co-coordination ratio (CCR) values calculated from the measurements of the BTS FreeEMG 300 were used.ResultsIn the comparison before and after group intervention in terms of FMA, the EG showed significant changes in all items of FMA, but the CG showed significant changes only in the shoulder items ( p < 0.05). In the comparison between groups, significant differences were observed only in the total score of FMA ( p < 0.05). In terms of the CCR value, positive changes were found in the EG in all items except for the shoulder flexion, but negative changes were observed in all items in the CG.ConclusionIt was confirmed that the TOMP applied in this study can have a positive effect on upper limb function and coordination in chronic stroke patients.
Understanding the Roles of Sport and Alcohol Use in Adolescence on Physical and Sexual Intimate Partner Violence Perpetration in Young Adulthood: Findings From a Sex-Stratified Multilevel Analysis
Authors: Barker Kathryn M. , Raj Anita 
Published: March 2022

Adolescent peer groups shape beliefs that dictate behavioral norms, including intimate partner violence (IPV) perpetration behaviors, with lasting influence into adulthood. This study examines the role of sport engagement and alcohol use in adolescence on perpetration of physical and sexual IPV in young adulthood. A secondary data analysis was conducted with data from 3411 male and 4318 female participants in the National Longitudinal Study of Adolescent to Adult Health study. Sports and other school activity participation, as well as alcohol use, were measured in middle and high school students. Intimate partner violence perpetration was measured six years later with items from the revised Conflict Tactics Scales. Sex-stratified logistic cross-classified multilevel analyses indicate that, for males, participation in football in adolescence was associated with higher odds of IPV perpetration in young adulthood (aOR:1.26, p = .01). For males and females, non-engagement in any school activities in adolescence was associated with higher odds of IPV perpetration in young adulthood (male aOR: 1.52, p < .01; female aOR: 1.19, p = .04). Alcohol use in adolescence was also associated with higher odds of IPV perpetration in young adulthood for both males and females, even when low level drinking (1–2 drinks in the past 12 months) was reported (male aOR: 1.40, p < .01; female aOR: 1.38, p < .01). Random-effect estimates indicate small but significant contributions of adolescent peer, school, and neighborhood contexts on IPV perpetration in young adulthood for both boys and girls. These findings highlight that football engagement among boys, and alcohol use among boys and girls, are linked to longer-term risk for IPV perpetration, but engagement in other sports and school activities appear to serve as protective factors. These findings, taken with those regarding social context effects, suggest that positive social environment and networks in adolescence, inclusive of those offered in some sports, can be useful platforms for IPV prevention efforts.
Preference and ability to perform blood-versus oral-fluid-based HIV self-testing in adolescents and young adults in Bangkok
Authors: Trabwongwitaya Parin , Songtaweesin Wipaporn N , Paiboon Nantika , Wongharn Prissana , Moonwong Juthamanee , Phiphatkhunarnon Panyaphon , Sowaprux Teaka , Sophonphan Jiratchaya , Hansasuta Pokrath , Puthanakit Thanyawee 
Published: March 2022

Introduction: Adolescents and young adults (AYA) have limited access to HIV screening tests despite the risk of acquiring HIV infection. This study aims to understand AYA preferences and their ability to perform HIV self-tests (HIVST). Methods: A cross-sectional study looked at AYA preferences when offered a choice between blood-based (INSTI®) and oral fluid-based (OraQuick®) HIVST. Adolescents and young adult participants between 18 and 24 years-old who report inconsistent condom use or had a history of sexually transmitted diseases were enrolled. Participants were offered a choice between blood-based and/or oral fluid-based HIVSTs with explanations of the differences between two types. Then, written and short video instructions according to the chosen type were given before participants performed a test. The study seeks to understand test preference, ability to perform and interpret test results. Results: From March to April 2021, 87 AYA were enrolled with a median age of 20 years (interquartile range (IQR) 18–22). Of the participants, 54 (62.1%) were men who have sex with men (MSM), 25 (28.7%) were cisgender men or women and 8 (9.2%) were transgender women (TGW). There were 37 (42.5%) first-time HIV testers and 32 (36.8%) HIV PrEP users. There were 57 participants (65.6%, 95% CI 54.6%–75.4%) that preferred blood-based HIVSTs. Reasons for preferring blood-based testing were the rapid results (77.2%) and higher accuracy (66.7%). The ability to perform and interpret HIVST results were 89.5% and 98% among INSTI users and 93.3% and 100.0% among OraQuick® users. None was HIV-positive. Moreover, 13.8% of the participants initiated same-day pre-exposure prophylaxis (PrEP). Conclusions: Thai AYA preferred blood-based over oral fluid-based HIVSTs. Most AYAs were able to perform the HIVSTs and interpret results. Supervision and post-test counselling of HIVSTs should be implemented to ensure AYA gain benefits from HIVSTs.
Estimated Aggregate Treatment Benefit With Addition of Multiple Novel Medications for Secondary Prevention of Atherosclerotic Cardiovascular Disease
Authors: Ariss Robert W. , Gupta Rajesh 
Published: March 2022

Purpose: Interest in improving residual cardiovascular (CV) risk by targeting multiple causative pathways has been growing. Several medications including icosapent ethyl, rivaroxaban, and ezetimibe have been shown to individually improve outcomes in the secondary prevention of atherosclerotic cardiovascular disease (ASCVD) beyond conventional therapy consisting of aspirin and statins. While each drug has been shown to individually improve outcomes, the expected treatment benefit of the combined use of these drugs for enhanced secondary prevention of ASCVD is not known. Methods: In this cross-trial analysis, we estimated the aggregate treatment effect of comprehensive medical therapy consisting of icosapent ethyl, rivaroxaban, and ezetimibe added to background aspirin and statin therapy through established methods of indirect comparisons of the results of three key clinical trials (REDUCE-IT [n = 8,179], COMPASS [n = 27,395], and IMPROVE-IT [n = 18,144]). The primary endpoint was a composite of cardiovascular death, non-fatal myocardial infarction (MI), or non-fatal stroke. Secondary endpoints included each individual component of the primary endpoint. Results: The hazard ratio (HR) of the imputed aggregate treatment effects for enhanced secondary prevention of ASCVD with comprehensive disease modifying therapy compared to aspirin and statin alone for the primary endpoint was 0.51 (95% confidence interval [CI] 0.42-0.61). The HR for CV death was 0.62 (95% CI 0.46-0.85), non-fatal MI was 0.52 (95% CI 0.40-0.69), and non-fatal stroke was 0.35 (95% CI 0.23-0.54). The results were similar in sensitivity analyses. Conclusion: The estimated aggregate treatment effect of enhanced secondary prevention of ASCVD through comprehensive medical therapy is substantial. This exploratory analysis supports further study of comprehensive therapy to reduce residual CV risk for the secondary prevention of ASCVD.
MiR-379-5p Promotes Chondrocyte Proliferation via Inhibition of PI3K/Akt Pathway by Targeting YBX1 in Osteoarthritis
Authors: Zhang Hongjun , Zheng Wendi , Li Du , Zheng Jia 
Published: March 2022

Objective We evaluated the ability of miR-379-5p to influence the proliferation of osteoarthritis chondrocytes and elucidated the regulatory mechanism of miR-379-5p in osteoarthritis. Methods Real time polymerase chain reaction (RT- PCR) was used to detect the expression of miR-379-5p and YBX1 in knee articular cartilages of human. Cell proliferation, inflammatory factors, extracellular matrix (ECM) degradation-associated proteins and proteins in PI3K/Akt pathway were assessed in rat primary chondrocytes treated with interleukin (IL)-1β or/and miR-379-5p mimics or miR-379-5p inhibitor via cell counting assay kit-8 (CCK-8), enzyme-linked immunosorbent assay (ELISA), immunofluorescence and Western blotting (WB). The target of miR-379-5p predicted by TargetScan and miRwalk software was verified by luciferase reporter assay. Safranin O-fast green staining, immunohistochemistry, and WB were performed to observe the effect of miR-379-5p agomir on development of osteoarthritis in rats. Results MiR-379-5p was down-regulated in human osteoarthritic tissues and negatively correlated with YBX1 expression. High level of miR-379-5p in chondrocytes with IL-1β stimulated increased cell viability, the expression of proliferation-related protein and extracellular matrix (ECM)-related proteins collagen II and aggrecan. However, the expression of inflammatory factors and ECM-related proteins matrix metalloproteinases (MMP-1) and MMP-13 was decreased. Luciferase reporting assay verified the targeting relationship between miR-379-5p and YBX1. This function of miR-379-5p was exerted through PI3K/Akt pathway and could be blocked by the PI3K/Akt pathway inhibitor LY294002. MiR-379-5p agomir promoted the articular chondrocytes proliferation and alleviated cartilage degradation in vivo. Conclusion Our findings reveal that miR-379-5p can promote the articular chondrocytes proliferation in osteoarthritis (OA) by interacting with YBX1 and regulating PI3K/Akt pathway. Restoring miR-379-5p might be a future therapeutic strategy for OA.
How Long Does It Take to Achieve Clinically Significant Outcomes After Isolated Biceps Tenodesis?
Authors: Lu Yining , Agarwalla Avinesh , Lavoie-Gagne Ophelie , Patel Bhavik H. , Beletsky Alexander , Nwachukwu Benedict U. , Verma Nikhil N. , Cole Brian J. , Forsythe Brian 
Published: March 2022

Background: Clinically significant outcomes (CSOs) connect patient-reported outcome measures data to patient-perceived benefit. Although investigators have established threshold values for various CSOs, the timeline to achieve these outcomes after isolated biceps tenodesis (BT) has yet to be defined. Purpose: To define the time-dependent nature of minimal clinically important difference (MCID), substantial clinical benefit (SCB), and Patient Acceptable Symptom State (PASS) achievement after isolated BT. Study Design: Case series; Level of evidence, 4. Methods: The American Shoulder and Elbow Surgeons score (ASES), the Single Assessment Numeric Evaluation, and the Constant-Murley score (CMS) were administered preoperatively and at 6 and 12 months postoperatively to patients undergoing isolated BT between 2014 and 2018 at our institution. Cumulative probabilities for achieving MCID, SCB, and PASS were calculated using Kaplan-Meier survival analysis. Weibull parametric regression evaluated the hazard ratios (HRs) of achieving earlier MCID, SCB, and PASS. Results: Overall cohort (N = 190) achievement rates ranged between 77.8% and 83.2% for MCID, between 42.2% and 80.2% for SCB, and between 59.7% and 62.9% for PASS. Median achievement time was 5.3 to 6.1 months for MCID, 5.9 to 6.4 months for SCB, and 6.07 to 6.1 months for PASS. Multivariate Weibull parametric regression identified older age, male sex, higher body mass index, preoperative thyroid disease, smoking history, and higher preoperative CMS as predictors of delayed CSO achievement (HR, 1.01-6.41), whereas normal tendon on arthroscopy, defined as absence of tenosynovitis or tendon tear on arthroscopy, predicted earlier CSO achievement (HR, 0.19-0.46). Location of tenodesis and worker compensation status did not significantly predict the time to achieve CSOs on multivariate analysis. Conclusion: After isolated BT, patients can expect to attain CSO by 13 months postoperatively, with most patients achieving this between 5 and 8 months. Patients tend to take longer to achieve PASS than MCID and SCB.
Photodynamic Therapeutic Effect of Nanostructured Metal Sulfide Photosensitizers on Cancer Treatment
Authors: Diaz-Diestra Daysi , Gholipour Hanna Madadi , Bazian Marjan , Thapa Bibek , Beltran-Huarac Juan 
Published: March 2022

AbstractPhotodynamic therapy (PDT) utilizes photosensitizers (PSs) to produce reactive oxygen species (ROSs) upon irradiation, which causes the shutdown of vessels and deprives the tumor of nutrients and oxygen, and in turn induces adverse effects on the immune system. However, significant efforts are needed to increase the efficiency in PDT in terms of light delivery to specific PSs for the clinical treatment of tumors located deep under the skin. Even though PDT offers a disease site-specific treatment modality, current efforts are directed to improve the solubility (in body fluids and injectable solvents), photostability, amphiphilicity (for tissue penetration), elimination, and systemic toxicity of traditional PSs based on porphyrin derivatives. Nanostructured materials show promising features to achieve most of such combined efforts. They can be artificially engineered to carry multiple theranostic agents onto targeted tumor sites. However, recent studies on photosensitive Cd-based nanostructures, mostly used in PDT, indicate that leeching of Cd2+ ions is stimulated when they are exposed to harsh biological conditions for continuous periods of time, thus making them acutely toxic and hindering their applications in in vivo settings. Since nanostructured materials are not completely immune to degradation, great strides have been made to seek new alternatives. In this review, we focus on the latest advances of Cd-free nanostructured metal transition sulfides (MTSs) as alternative PSs and study their high-energy transfer efficiency, rational designs, and potential applications in cancer-targeted PDT. Nanostructured MTSs are discussed in the context of their versatility to serve as phototherapy agents and superior properties, including their strong absorption in the NIR region, excellent photothermal conversion efficiency, controlled reactive oxygen species (ROS) production, versatile surface chemistry, high fluorescence, and structural and thermal stability. We discuss the latest advancements in correlating the self-aggregation of MTSs with their passive tumor cell targeting, highlighting their ability to efficiently produce ROSs, and mitigating their dark toxicity through polymeric functionalization. Treatment of deep-seated tumors by using these PSs upon preferential uptake by tumor tissues (due to the enhanced permeability and retention effect) is also reviewed. We finally summarize the main future perspectives of MTSs as next-generation PSs within the context of cancer theranostics.
Graphical Abstract
Dissecting of the Deterioration in Eating Quality for Erect Panicle (Ep) Type High Yield Japonica Super Rice in Northest China
Authors: Chen Sibo , Chen Shuangjie , Jiang Yihui , Lu Qing , Liu Zhongyuan , Liu Wanying , Wang Xuhong , Shi Wenhua , Xu Quan , Sun Jian , Zhang Fan , Tang Liang 
Published: March 2022

AbstractEp type is an important morphological improvement (following dwarf breeding and ideal plant type) that has contributed to breeding super-high yielding, and shows a pleiotropic effect in increasing grain yield and also nitrogen-use efficiency (NUE) in rice. Nevertheless, it remains unclear whether Ep has adverse effects on eating quality and how it affects nitrogen uptake and assimilation. In this study, we developed a pair of near-isogenic lines (NILs) for panicle type (NIL-Ep, NIL-non Ep) in the Liaogeng 5 (LG5) and Akihikari (AKI) backgrounds. Rice plants of the NIL-Ep had higher grain numbers per panicle in the middle to bottom spike positions than plants of the NIL-non Ep. The increased grain number is not only is the key factor leading to increased yield but also is the reason for reduced the eating quality. The content of prolamin and glutelin was significantly higher in NIL-Ep, which resulted in higher hardness and worse viscosity of rice after cooking. In addition, the activity of several essential enzymes catalyzing nitrogen metabolism was higher in the NIL-Ep line grains than in the NIL-non Ep, especially from the mid to late grain filling stage. Based on these results, we conclude that Ep positively regulates grain protein accumulation, primarily through enhancing the activity of enzymes involved in nitrogen assimilation and redistribution during the mid to late grain-filling stage, resulting in excessive accumulation of grain protein and decreased eating quality.
Bladder inflammatory myofibroblastic tumor: report of four cases
Authors: Villalba Bachur Roberto F. , Meo Mauro Marcelo , Córdoba Andrés Felipe , Chemi Joaquin , Camean Juan J. , Jaunarena Jorge H. , Gonzalez Matias , Villoldo Gustavo M. 
Published: March 2022

Abstract
Background
Inflammatory myofibroblastic tumor (IMT) of the bladder (BIMT) is a rare entity with non-specific symptoms and particular histological features. Though bladder location is very uncommon, it arises from the bladder submucosal stroma as a polypoidal growth and is easily mistaken clinically, radiologically and histologically with a malignant neoplasm. The main treatment is surgical resection. To our knowledge, few reports of this pathology have been duly informed in Latin America to date.

Case presentation
We present four case male patients evidencing bladder tumor initially treated with transurethral bladder resection, diagnosing BIMT. They had shown tumor recurrence and laparoscopic treatment were decided without evidence of new recurrence.

Conclusion
Due to the few reports of this pathology, specially in South America, it is important to know its therapeutic management and follow-up.