bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sylimarin: Traditional and New Effects
Authors: Силивончик Н.Н. , Якубчик Т.Н. 
Published: March 2022

Силимарин – смесь изомерных флавонолигнанов расторопши пятнистой (Silybum marianum). В статье представлена характеристика фармакологических свойств силимарина, характеристика стандартизированного экстракта расторопши по силимарину и силибину Легалон (Legalon)®, клинические эффекты с обзором результатов применения силимарина при заболеваниях печени различной этиологии. Представлены данные об эффектах силимарина при перегрузке железа, онкологических заболеваниях, сахарном диабете. Приведены литературные данные с обоснованием потенциальных эффектов силимарина в отношении вируса SARS-CoV-2 как основа для разработки новых противовирусных препаратов или подходов к поддерживающей терапии инфекции COVID-19.
Silymarin is a mixture of isomeric flavonolignans from milk thistle (Silybum marianum). This article presents characteristics of pharmacological properties of silymarin, characteristics of standardized milk thistle extract for silymarin and silybin Legalon (Legalon®), clinical effects with an overview of results of use of silymarin in liver diseases of various etiologies. Data on effects of silymarin in iron overload, oncological diseases, diabetes mellitus are presented. Literature date provides substantiation of potential effects of silymarin on SARS-CoV-2 virus as a basis for development of new antiviral drugs or approaches to maintenance therapy for COVID-19 infection.
Possibilities of Using Complex Natural Medicines in Patients with Osteoarthritis (Fredulex)
Authors: Тябут Т.Д. , Кундер Е.В. , Буглова А.Е. , Руденко Е.В. 
Published: March 2022

В статье изложены современные представления о фенотипах остеоартрита (ОА), принципах немедикаментозного и медикаментозного лечения, предложенных в международных рекомендациях. Представлены основные результаты публикаций, рассматривающих возможности применения компонентов лекарственных растений и нутрицевтиков (босвеллия, куркума, экстракт черного перца, гиалуроновая кислота, коллаген) у пациентов с остеоартритом с учетом их эффективности и безопасности.
The article presents current views on the phenotypes of osteoarthritis (OA), principles of non-pharmacological treatment and pharmacological therapy proposed in the international recommendations. We have summarized main results of publications considering the possibility of using medicinal plant components and nutraceuticals (Boswellia, turmeric, black pepper extract, hyaluronic acid, collagen) in patients with osteoarthritis with regard to their effectiveness and safety.
How Microbiota Forms Rheumatic Diseases? Part 2
Authors: Рудой А.С. 
Published: March 2022

В кишечнике человека обитает чрезвычайно разнообразное и обильное микробное сообщество, которое корректирует и даже модулирует многие процессы, связанные со здоровьем. «Интерфейсы» слизистой оболочки являются особенно активными участками взаимодействия микроорганизмов и хозяев. Возрастающее понимание характерного состава и функции микробиоты кишечника выявило, что она не только участвует в поддержании целостности слизистой оболочки, но и затрагивает гомеостаз системы иммунитета с формированием как локальных, так и системных иммунных реакций. В представленном обзоре рассмотрена роль нарушений устойчивого состояния и взаимодействия хозяин – микроорганизм, которые могут потенциально влиять на развитие и прогрессирование ревматических заболеваний. В заключение будут рассмотрены вопросы новых терапевтических целей коррекции микробиоты.
The human gut harbours a tremendouslydiverse and abundant microbial community that corrects and even modulates many health-related processes. The “interfaces” of the intesinal mucous of in are particularly active sites of interaction between microorganisms and hosts. Growing insight into the characteristic composition and function of the gut microbiota has revealed that it is involved not only in maintaining the integrity of the mucous membrane, but also affects the homeostasis of the immune system with the formation of both local and systemic immune responses. This review considers in the host – microorganism interplay, which can potentially affect the development and progression of rheumatic diseases. In conclusion, the issues of new therapeutic goals of microbiota correction will be consider.
Correction of Reproductive Disorders in Women with Multiple Drug-Resistant Tuberculosis
Authors: Солонко И.И. , Скрягина Е.М. , Рогова З.И. 
Published: March 2022

Приведен алгоритм лечения нарушений репродуктивной функции у женщин с туберкулезом с множественной лекарственной устойчивостью (МЛУ-ТБ), который включал установление типа репродуктивных нарушений, гормональную коррекцию, консультирование и лечение у смежных специалистов. Показано, что адекватная гормональная терапия в течение 3 месяцев способствовала нормализации гормонального профиля, маточной перфузии и становлению ритмичного менструального цикла у 94,1% пациенток. Комплексный подход к коррекции нарушений репродуктивной функции у пациенток с туберкулезом, основанный на учете показателей эндокринного профиля, позволяет предупредить развитие нежелательной беременности, повышает приверженность к лечению основного заболевания и улучшает репродуктивный прогноз.
An algorithm for treating reproductive disorders in women with multiple drug-resistant tuberculosis (MDR-TB) is presented, which includes establishing the type of reproductive disorder, hormonal correction, counselling, and treatment by related specialists. It was showed that adequate hormone therapy for 3 months contributed to normalization of hormonal profile, uterine perfusion, and formation of rhythmic menstrual cycle in 94.1% of patients. A comprehensive approach to the correction of reproductive disorders in patients with tuberculosis, based on endocrine profile indicators, lets to prevent the development of unwanted pregnancies, increases commitment to the treatment of the main disease, and improves reproductive prognosis.
Acute Gastroenteritis in Children. Updated ESPGHAN 2020 Guidelines
Authors: Белоусова О.Ю. 
Published: March 2022

Острые кишечные инфекции занимают второе место в структуре инфекционных заболеваний, уступая только респираторным инфекциям. Высокая частота острых кишечных инфекций у детей, большая часть из которых приходится на пациентов раннего возраста, определяет необходимость разработки современных рекомендаций по их диагностике и лечению. При этом длительность заболевания и его исход напрямую зависят от своевременности и адекватности назначенной терапии. Что касается применения пробиотиков, известно, что различные пробиотические штаммы отличаются по своим клиническим эффектам.Обзор проблемы основывается на рекомендациях Европейского общества детских гастроэнтерологов, гепатологов, диетологов (ESPHGAN), содержащих обновленные рекомендации по использованию пробиотиков для лечения острого гастроэнтерита у младенцев и детей, которые раньше считались здоровыми. С момента публикации в 2014 году Руководства Рабочей группы ESPGHAN по пробиотикам и пребиотикам в отношении пробиотиков для лече ния острого гастроэнтерита появились новые доказательства эффективности пробиотиков. В связи с появившимися новыми данными, полученными с учетом доказательной медицины, документ был обновлен 2020 году.
High prevalence of acute enteric infections in children, the majority of which affects infants, determines the necessity of development of modern recommendation on diagnostics and treatment of such conditions. However, disease duration and outcome depend on timelines and adequacy of the prescribed treatment. Acute intestinal infections occupy the second place in the structure of infectious diseases, second only to respiratory infections. With regard to the use of probiotics, it is known that different probiotic strains differ in their clinical effects.The review is based on the recommendations of the European Society of Pediatric Gastroenterology, Hepatology, Nutritional Medicine (ESPHGAN), which contains updated recommendations for the use of probiotics for the treatment of acute gastroenteritis in infants and children previously considered healthy. Since the publication of the ESPGHAN Probiotics and Prebiotics Working Group Guidelines for Probiotics for Acute Gastroenteritis in 2014, new evidence has emerged for the effectiveness of probiotics. In connection with the emerging new data obtained taking into account evidence- based medicine, the document was updated in 2020.
Kelayakan tepung darah dalam pembuatan pakan untuk pertumbuhan ikan nila, Oreochromis niloticus)
Authors: Takou Putri D. , Mokolensang Jeffrie F. , Pangkey Hanneke , Lumenta Cyska , Manoppo Henky , Wantasen Adnan S. 
Published: March 2022

The purpose of this study was to determine the feasibility of blood meal in various level inclusins in promoting the growth rate and nutrient utilization of O. niloticus. The results showed that the absolute growth of tilapia in treatment 2 (with a combination of 20%) was higher than the other treatments. The daily growth rate of tilapia in treatment 2 (3.5% / day) was higher than other treatments. Likewise, with the feed change value, treatment 2 showed significantly different from other treatments. The combination of tuna fish meal waste and blood meal showed significantly different results from the results of statistical tests
Studi kualitas air di area akuakultur Desa Eris Kabupaten Minahasa
Authors: Sinaga Rohana , Undap Suzanne L. , Kusen Diane J. , Pangemanan Novie P. L. , Mudeng Joppy D. , Pangemanan Jeannette 
Published: March 2022

The aim of this study was to monitor the condition of water quality in the aquaculture area of fix net cage culture system (KJT) at Lake Tondano, Eris Village, Eris District, Minahasa Regency which included temperature, pH, DO, TDS, Turbidity, NO2, NH3, PO4 and sediment (N, Nitrogen and P, Phosphorus) in a different time. This research was conducted from March to May 2021 using a survey method. The research activities consisted of direct measurements in the field (in situ) using a Horiba U-5000G instrument and laboratory analysis (ex situ) at the BTKLPP Class 1 Laboratory and the BARISTAND Laboratory in Manado for primary data. Primary data was carried out at 3 points, Point 1 represented around residential activities, Point 2 where the areas of cultivation activities, and Point 3 where outside of cultivation and settlement activities. Primary data was compared with secondary data i.e, publish articles and then processed in the STORET method. Data were evaluated to the water quality parameters standard according to the Indonesian Government Regulation number 22 of 2021. The results showed that the water temperature ranged between 26.3 - 28.07 0C, Turbidity (10.5 - 24.4 NTU), TDS (0.167 - 0.172 g/L), pH (3.79 - 7.84), DO (1.87 - 9.05 mg/L), NH3 (0.12 - 0.26 mg/L) , NO2 (0.001 - 0.064 mg/L), PO4 (0.2 mg/L - 1.67 mg/L). In the sediment samples, N was found in the ranged of 0.20% - 0.26% and P (0.48% - 2.69%). It can be concluded, the condition of water quality in the aquaculture area using KJT in Eris Village is categorized as class C (medium polluted) and N in the sediment criteria is moderate and the content of P in the sediment criteria is very low.
Studi dan Analisis Pengembangan Smart Campus Application Framework Menggunakan Pendekatan Microservices Architectures
Authors: Jumiyani Rahil , Wisnuadhi Bambang 
Published: March 2022

Abstract- A smart campus applications are a set of applications developed to support a realization of smart campus paradigm. There is a possibility of development doing regularly because business domain requirements in a university area are highly dynamic and complex. A consideration for estimated potential impacts needs to be involved for long-term goals and strategy planning to embody smart campus vision. One of those is defining appropriate system architecture. The approach of microservices architecture can be used in this development because it allows evolution activities doing continuously. The evolution activities are possible because there are business requirements changes, activity of performances and reliability improvements. A selection of architecture which is sufficient scalability requirement of smart campus application can be done by defining their characteristics, especially availability of scalability aspect. It will have an impact on efficiency cost of continuous development. This study focuses on microservices architectures as smart campus framework architecture in study case of smart campus application development in Politeknik Negeri Bandung. Abstrak- Smart campus application adalah sistem yang dibangun untuk mendukung kebutuhan smart campus. Kebutuhan business domain di lingkungan perguruan tinggi yang sangat dinamis dan kompleks tidak menutup kemungkinan terhadap upaya pengembangan aplikasi secara berkala. Pertimbangan terhadap proyeksi potensi dampak yang akan terjadi perlu dilibatkan dalam tujuan dan perencanaan jangka panjang serta strategi dalam pengembangan aplikasi yang mendukung terwujudnya visi smart campus, salah satunya dengan mendefinisikan arsitektur sistem yang sesuai. Microservices architecture merupakan pendekatan yang dapat digunakan dalam pengembangan aplikasi yang memudahkan dilakukan kegiatan evolusi secara berkesinambungan dengan adanya perubahan business environment, peningkatan perfomansi dan reliabilitas sistem. Pemilihan arsitektur yang memenuhi kebutuhan skalabilitas smart campus applications dapat dilakukan dengan memperhatikan karakteristik yang memenuhi kriteria tertentu, khususnya konteks skalabilitas, sehingga pengembangan aplikasi dapat dilakukan dengan lebih cost efficient. Kajian ini akan berfokus pada studi kelayakan teknis microservices architecture sebagai arsitektur dasar dalam pengembangan Framework Smart Campus pada studi kasus di lingkungan Politeknik Negeri Bandung.
Contribuições para aumentar o potencial econômico-financeiro em projetos de produtos e serviços baseados em design thinking
Authors: Silva Pinto Marcelo , Machado Rocha Alexandre , Copola Azenha Flávio , Delage e Silva Gabriel , Leme Fleury André 
Published: March 2022

Projetos baseados em design thinking ganharam muito espaço no âmbito da gestão e desenvolvimento de projetos visando inovação. Muitos negócios incorporaram a abordagem, porém não está consolidado o fato de que o processo é passível para desenvolvimento de produtos e serviços que realmente gerem captação de valor para os negócios. Por isso, o trabalho apresentado buscou compreender como se dá o processo de capitação de valor em projetos baseados em design thinking por meio de uma ampla revisão de literatura e estudos de dez casos. A pesquisa identificou lacunas na literatura e descobertas nos estudos de caso que contribuem para o desenvolvimento da teoria e prática sobre o tema. Os resultados podem contribuir ainda, para gestores e empreendedores dialogarem de maneira mais eficiente com designers e projetistas, possibilitando assim, projetos alinhados com as expectativas dos envolvidos, aumentando a captação de valor nos projetos.
The Effect of Multilevel Doses of Caffeine on Tissue Macrophage and Blood Lymphocyte Count in Autologous Full Thickness Skin Graft Healing in Sprague Dawley Rats
Authors: Prabowo Wahyu Haris , Awal Prasetyo  , Neni Susilaningsih  
Published: March 2022

Backgrounds. A skin graft is one of the routine surgical procedures performed. This procedure gives excellent results when done as early as possible after the trauma. Caffeine has a mechanism as an adenosine-receptor A2 antagonist which can induce wound healing through increased angiogenesis. This study aimed to determine the efficacy of coffee caffeine in the initiation of full thickness skin graft autologous wound healing by assessing the number of macrophages and lymphocytes in Sprague-Dawley rats.
Methods. The research design is an experimental study with a post-test-only approach with a control group design. Twenty male Sprague Dawley rats aged 15 weeks (140 – 150 grams) were randomly divided into four groups. One group became the control group (decaffeinated) while the other group received various doses of caffeine (3 mg/kgBW, 6 mg/kgBW, and 9 mg/kgBW). Autologous skin grafts were performed in all groups. HE examination was performed to confirm the number of macrophage cells in the tissue. Data analysis was carried out with the help of SPSS 25 software.
Results. There were significant differences in the number of tissue macrophages in the four groups. The group that received 9 mg/kgBW of caffeine showed the highest number of macrophages compared to the other groups. Based on the number of lymphocytes in the peripheral blood, the group that received a dose of 6 mg/kg BW showed the highest number of lymphocytes compared to other groups.
Conclusion. Caffeine showed the ability to initiate full thickness skin graft autologous wound healing by increasing the number of macrophages and lymphocytes in Sprague Dawley rats.
Tanggung Gugat Dokter Atas Kelalaiannya Dalam Menyampaikan Informed Conset Dan Hasil Operasi Yang Tidak Sesuai Dengan Keinginan Pasien
Authors: Santoso Bezaleel Nugara 
Published: March 2022

The society is not only an object of healt enforcement, but also a subject. Therefore, the enforcement of health services is a joint responsibility of the health care providers and the health care recipients. In the application of the profession, a doctor cannot be separated from the health law. However, it is important to acknowledge that a doctor is a common human being who can also make mistakes or commit malpractice in doing his job. A doctor can be hold responsible on the criminal law, civil law, and administrative law. In civil law, a doctor can be hold responsible based on a law violating act and breach of contract. Breach of contract happens when one of the party does not perform what is promised, perform what is promised later than it is supposed to be, perform what is promised below the expectation promised. Meanwhile, an action is considered violating the law when it fulfills the four criteria such as the existence of an action againt the law, there must be a mistake, there must be a loss/damage caused by the action, and there must be a causal relation between the action and the loss/damage. A law violating act does not only mean violating the regulations, but also failing to do the law obligation of the perpetrator, violating other people’s subjective rights, violating the ethics, and violating decency, accuracy and circumspection.
Stellar Mass-to-light Ratios: Composite Bulge+Disk Models and the Baryonic Tully–Fisher Relation
Authors: Schombert James , McGaugh Stacy , Lelli Federico 
Published: March 2022

Abstract
We present stellar population models to calculate the mass-to-light ratio (ϒ*) based on galaxies’ colors ranging from GALEX far-UV to Spitzer IRAC1 at 3.6 μm. We present a new composite bulge+disk ϒ* model that considers the varying contribution from bulges and disks based on their optical and near-IR colors. Using these colors, we build plausible star formation histories and chemical enrichment scenarios based on the star formation rate–stellar mass and mass–metallicity correlations for star-forming galaxies. The most accurate prescription is to use the actual colors for the bulge and disk components to constrain ϒ*; however, a reasonable bulge+disk model plus total color only introduces 5% more uncertainty. Full bulge+disk ϒ* prescriptions applied to the baryonic Tully–Fisher relation improve the linearity of the correlation, increase the slope, and reduce the total scatter by 4%.
Two New Black Widow Millisecond Pulsars in M28
Authors: Douglas Andrew , Padmanabh Prajwal V. , Ransom Scott M. , Ridolfi Alessandro , Freire Paulo , Krishnan Vivek Venkatraman , Barr Ewan D. , Pallanca Cristina , Cadelano Mario , Possenti Andrea , Stairs Ingrid , Hessels Jason W. T. , DeCesar Megan E. , Lynch Ryan S. , Bailes Matthew , Burgay Marta , Champion David J. , Karuppusamy Ramesh , Kramer Michael , Stappers Benjamin , Vleeschower Laila 
Published: March 2022

Abstract
We report the discovery of two Black Widow millisecond pulsars in the globular cluster (GC) M28 with the MeerKAT telescope. PSR J1824−2452M (M28M) is a 4.78 ms pulsar in a 5.82 hr orbit, and PSR J1824−2452N (M28N) is a 3.35 ms pulsar in a 4.76 hr orbit. Both pulsars have dispersion measures near 119.30 pc cm−3 and have low-mass companion stars (∼0.01–0.03 M
⊙) that do not cause strong radio eclipses or orbital variations. Including these systems, there are now five known black widow pulsars in M28. The pulsar searches were conducted as a part of an initial phase of MeerKAT’s GC census (within the TRAPUM Large Survey Project). These faint discoveries demonstrate the advantages of MeerKAT’s survey sensitivity over previous searches, and we expect to find additional pulsars in continued searches of this cluster.
Sizes of Lensed Lower-luminosity z = 4–8 Galaxies from the Hubble Frontier Field Program
Authors: Bouwens R. J. , Illingworth G. D. , van Dokkum P. G. , Oesch P. A. , Stefanon M. , Ribeiro B. 
Published: March 2022

Abstract
We constrain the rest-UV size–luminosity relation for star-forming galaxies at z ∼ 4 and z ∼ 6, 7, and 8 identified behind clusters from the Hubble Frontier Fields (HFF) program. The size–luminosity relation is key to deriving accurate luminosity functions (LF) for faint galaxies. Making use of the latest lensing models and full data set for these clusters, lensing-corrected sizes and luminosities are derived for 68 z ∼ 4, 184 z ∼ 6, 93 z ∼ 7, and 53 z ∼ 8 galaxies. We show that size measurements can be reliably measured up to linear magnifications of ∼30×, where the lensing models are well calibrated. The sizes we measure span a >1 dex range, from <50 pc to ≳500 pc. Uncertainties are based on both the formal fit errors and systematic differences between the public lensing models. These uncertainties range from ∼10 pc for the smallest sources to 100 pc for the largest. Using a forward-modeling procedure to model the impact of incompleteness and magnification uncertainties, we characterize the size–luminosity relation at both z ∼ 4 and z ∼ 6–8. We find that the source sizes of star-forming galaxies at z ∼ 4 and z ∼ 6–8 scale with luminosity L as L
0.54±0.08 and L
0.40±0.04, respectively, such that lower-luminosity (≳−18 mag) galaxies are smaller than expected from extrapolating the size–luminosity relation at high luminosities (≲−18 mag). The new evidence for a steeper size–luminosity relation (3σ) adds to earlier evidence for small sizes based on the prevalence of highly magnified galaxies in high-shear regions, theoretical arguments against upturns in the LFs, and other independent determinations of the size–luminosity relation from the HFF clusters.