bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Prognostic Significance of the Circumferential Resection Margin in Esophageal Squamous Cell Carcinoma Patients Without Neoadjuvant Treatment
Authors: Yang Zhaoyang , Lin Hua , Wang Zhen , Rong Lulu , Zhang Xuchen , Wang Lin , Qin Jianjun , Xue Xuemin , Li Yin , Xue Liyan 
Published: February 2022

Abstract
Background: Circumferential resection margin (CRM) is very important in esophageal cancer, but its diagnostic criteria has not been unified. The College of American Pathologists (CAP) and the Royal College of Pathologists (RCP) provide two different criteria. The aim of this study is to evaluate the long-term prognostic significance of CRM status with different CRM criteria in esophageal squamous cell carcinoma (ESCC).Methods: Influence of CRM status according to the CAP and RCP criteria on long-term survival of 838 patients with resected pT3 tumors and without neoadjuvant therapy was analyzed. Patients stratified into three groups on the basis of tumor distance from the CRM (>1 mm, 0-1 mm, 0 mm) were also analysed.Results: Positive CRM was found in 59 (7%) patients according to the CAP criteria and 317(37.8%) patients according to the RCP criteria. Univariate and multivariate survival analysis showed that CRM status, according to three different criteria, was independent prognostic factor. However, subgroup analysis showed that the prognostic value of CRM status was limited to certain metastatic lymph node load. In pN0 subgroup, patients with CRM > 1mm had better prognosis than patients with CRM 0-1mm. Patients with CRM 0 mm had worse outcome than patients with CRM > 0 mm in pN1-2 subgroup. But CRM status had no prognosis value in pN3 subgroups. Conclusions: The CRM status is an important prognostic factor in ESCC patients, but this effect was limited to patients without or with less lymph node metastasis (pN0-2). In clinical practice, we recommend the three-tier criteria as it provides more prognostic value than the traditional two-tier criteria.
Combination of Serological Biomarkers and Clinical Features to predict Mucosal Healing in Crohn’s Disease: A Multicenter Cohort Study
Authors: Zhang Hongjie , Tang Nang , Chen Han , Chen Ruidong , Tang Wen 
Published: February 2022

Abstract
Purpose: Mucosal healing (MH) has become the treatment goal of patients with Crohn’s disease (CD). This study aims to develop a noninvasive and reliable clinical tool for individual evaluation of mucosal healing in patients with Crohn’s disease. Methods: A multicenter retrospective cohort was established. Clinical and serological variables were collected. Separate risk factors were incorporated into a binary logistic regression model. A primary model and a simple model were established, respectively. The model performance was evaluated with C-index, sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) and accuracy. Internal validation was performed in patients with small intestinal lesions.Results: A total of 348 consecutive patients diagnosed with CD who underwent endoscopic examination and review after treatment from January 2010 to June 2021 were composed in the derivation cohort, and 112 patients with small intestinal lesions were included in the validation cohort. The following variables were independently associated with the MH and were subsequently included into the primary prediction model: PLR (platelet to lymphocyte ratio), CAR (C-reactive protein to albumin ratio), ESR (erythrocyte sedimentation rate), HBI (Harvey-Bradshaw Index) score and infliximab treatment. The simple model only included factors of PLR, CAR and ESR. The primary model performed better than the simple one in C-index (87.5% vs 83.0 %, p=0.004). There was no statistical significance between these two models in sensitivity (70.43% vs 62.61%, p=0.467), specificity (87.12% vs 80.69%, p=0.448), PPV (72.97% vs 61.54%, p=0.292), NPV (85.65% vs 81.39%, p=0.614), and accuracy (81.61% vs 74.71%, p=0.303). The primary model had good calibration and high levels of explained variation and discrimination in validation cohort. Conclusions: This model can be used to predict MH in post-treatment patients with CD. It can also be used as an indication of endoscopic surveillance to evaluate mucosal healing in patients with CD after treatment.
COVID Tarnish Lung: Residual Radiological Lung Consequences of Infection
with COVID-19
Authors: Abumossalam Ahmed Mohammed , Abdelgawad Taha Taha , Ibrahim Mohamad Abomesllam , Mohamad Mohamad Darwish , Ahmed Dalia Abdelsattar , Elhalaby Hanan Abdelsattar 
Published: February 2022

Background:
COVID-19 has still been expressed as a mysterious viral infection with dramatic pulmonary consequences.

Objectives:
This article aims to study the radiological pulmonary consequences of respiratory covid-19 infection at 6 months and their relevance to the clinical stage, laboratory markers, and management modalities.

Methods:
This study was implemented on two hundred and fifty (250) confirmed positive cases for COVID-19 infections. One hundred and ninety-seven cases (197) who completed the study dis-played residual radiological lung shadowing (RRLS) on follow-up computed tomography (CT) of the chest. They were categorized by Simple clinical classification of COVID-19 into groups A, B and C.

Results:
GGO, as well as reticulations, were statistically significantly higher in group A than the other two groups; however, bronchiectasis changes, parenchymal scarring, nodules as well as pleu-ral tractions were statistically significantly higher in group C than the other two groups.

Conclusion:
Respiratory covid-19 infection might be linked to residual radiological lung shadow-ing. Ground glass opacities GGO, reticulations pervaded in mild involvement with lower inflamma-tory markers level, unlike, severe changes that expressed scarring, nodules and bronchiectasis changes accompanied by increased levels of inflammatory markers.
Sociodemographic and Diabetes-related Risk Factors in San Diego County,
California
Authors: Muhseen Ziyad Tariq , Alfalki Ali Mamoon 
Published: February 2022

Background:
The research information would enable clinicians and public health professionals
to formulate proper interventions for diabetic people according to age, gender, and race.

Objective:
The aim of the study was to investigate the relationship between diabetes-related mortality,
hospitalization and emergency department discharge, and sociodemographic characteristics,
in addition to age-standardized mortality rate analysis.

Method:
A population-based cross-sectional descriptive study was carried out to determine the relationship
between sociodemographic characteristics and diabetes-related risk factors of the San
Diego County residents in 2018, including 49,283 individuals (27,366 males and 21,917 females).

Results:
The outcomes were found to be statistically significant. Hospitalization and emergency
department discharges among males and females were statistically significant. The statistical differences
between gender and mortality were not significant. The mortality was not significant in
the male group, while it was statistically significant in the female group. The noted agestandardized
mortality rate of diabetes stood at 85.8 deaths per 100,000 standard population.

Conclusion:
This study found that mortality increases as people age, and 85% of deaths were
found to be of people older than 65 years. The mortality was two times higher among white and
Hispanic males than females. Findings from this study are important in understanding the sociodemographic
characteristics at the county level, which can inform diabetes mortality prevention efforts.
A Review on the Importance of Annona muricata Crude Extract (AMCE) as a Nutraceutical Anti-Metastatic and its Coping Mechanism Against Breast Cancer
Authors: Medithi Srujana , Dalal Dimple 
Published: February 2022

Background:Annona Muricata is used as a folkloric herbal medicine as it has anticancer, antiproliferative, and anti-tumorigenic properties. The extracts from various parts of the plant are considered therapeutic due to Annonaceous Acetogenin compounds which are an absolute boon to the versatility of the plant, paving the mechanistic pathways for its therapeutic potential.Method:Google Scholar and PubMed databases were reviewed with the main focus on availing information on Annona muricata and its anticancer effect on breast cancer.Results and Discussion:An array of clinical investigations on the dosage of extracts on cell lines, animal models, and human trials provide confirmatory insights of A. muricata as a preventive and therapeutic measure for cancer. The extract, when administered at different dosages, shows a high cytotoxic effect on the cancer cells, mostly accounting for an IC50 of less than 1000μg/mL, which is of significance.Conclusion -:Although high efficacy has been conclusive, assurance of safety prior to commercialization is of significance. Investigations are required to define the origin and magnitude of side effects along with long-term safety for the enhancement of efficacy and optimum utilization of potential chemopreventive properties of the plant for the development of a cancer nutraceutical intervention that outperforms traditional medicine.
Papillary Lesions of the Breast: Addition of DWI and TIRM Sequences to
Routine Breast MRI Could Help in Differentiation Benign from Malignant
Authors: Sari Lutfullah , Gültekin Mehmet Ali , Yabul Fatma Çelik , Temur Hafize Otçu , Yilmaz Temel Fatih , Toprak Hüseyin , Yildiz Seyma 
Published: February 2022

Aim:
We aimed to investigate the magnetic resonance imaging (MRI) features of benign,
atypical, or malignant papillary breast lesions and to assess the additional value of diffusion-weighted
imaging (DWI) and turbo inversion recovery magnitude (TIRM) sequences to routine breast MRI.

Background:
Differentiation between benign and malignant papillary breast lesions is essential for
patient management. However, morphologic features and enhancement patterns of malignant papillary
lesions may overlap with those of benign papilloma.

Methods:
Seventy-two papillary breast lesions (50 benign, 22 atypical or malignant) were included in
the current study, retrospectively. We divided the patients into two groups: benign papillary breast
lesions and atypical or malignant papillary breast lesions. Morphologic, dynamic, turbo inversion recovery
magnitude (TIRM) values and diffusion features of the papillary lesions were compared between
two groups.

Results:
Benign papillary lesions were smaller in size (p=0.006 and p=0.005, for radiologists 1 and 2
respectively), closer to the areola (p=0.045 and 0.049 for radiologist 1 and 2 respectively), and had
higher ADC values (p=0.001 for two radiologists) than the atypical or malignant group. ROC curves
showed diagnostic accuracy for ADC (AUC=0.770 and 0.762, p & amp; lt; 0.0001 for two radiologists),
and showed a cut-off value of ≤ 957 x 10-6 mm2/s (radiologist 1) and ≤ 910 x 10-6 mm2/s (radiologist
2).

Conclusion:
MRI is a useful method for differentiation between benign and malignant papillary breast
lesions. Centrally located, lesser in size, and higher ADC values should be considered benign, whereas
peripherally located, larger in size, and lower ADC values should be considered malignant.
A Case of Toxoplasma gondii and Strongyloides stercoralis Coinfection in
an Immunocompromised Patient
Authors: Srivastava Saumya , Kundu Aditya , Sivakumar Haripriya , Tak Vibhor , Meena Durga Shankar , Samantray Subhashree , Kumar Deepak 
Published: February 2022

Background:
In India, around 23.49 lac people have HIV/AIDS (PLHA). Strongyloidiasis
and toxoplasmosis are some of the opportunistic infections that occur in HIV patients, but their dual
coinfection with HIV is rarely reported.

Case Presentation:
A 46-year-old male was admitted to the hospital with generalized weakness, loss
of weight, and bleeding per rectum for the last 3 months and a few episodes of dizziness and fever.

Results:
On routine investigation, he was diagnosed with human immunodeficiency virus (HIV) infection.
On further evaluation, Toxoplasma gondii and Strongyloides stercoralis coinfection, as assessed
by the parasitological diagnosis of the serum sample, was positive. Patient was started on artesunate,
ART regimen (Tab, TLD- Dolutegravir 50 + Lamivudine 300 + Tenofovir DF 300) and cotrimoxazole.

Conclusion:
Herein, we report a case of Toxoplasma gondii and Strongyloides stercoralis coinfection
in an immunocompromised patient.
Targeting Angiotensin-converting Enzyme 2 (ACE2) for the Discovery of Anticoronaviral Drugs
Authors: Moorthy Narayana Subbiah Hari Narayana , Karthikeyan Chandrabose , Manivannan Elangovan 
Published: February 2022

Abstract:Coronaviruses are a leading cause of emerging life-threatening diseases, as evidenced by the ongoing coronavirus disease pandemic (COVID-19). According to complete genome sequence analysis reports, severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), which causes COVID-19, has a sequence identity highly similar to the earlier severe acute respiratory syndrome coronavirus (SARSCoV). The SARS-CoV-2 has the same mode of transmission, replication, and pathogenicity as SARSCoV. The SARS-CoV-2 spike protein's receptor-binding domain (RBD) binds to host angiotensinconverting enzyme-2 (ACE2). The ACE2 is overexpressed in various cells, most prominently epithelial cells of the lung (surface of type 1 and 2 pneumocytes), intestine, liver, kidney, and nervous system. As a result, these organs are more vulnerable to SARS-CoV-2 infection. Furthermore, renin-angiotensin system (RAS) blockers, which are used to treat cardiovascular diseases, intensify ACE2 expression, leading to an increase in the risk of COVID-19. ACE2 hydrolyzes angiotensin- II (carboxypeptidase) to heptapeptide angiotensin (1-7) and releases a C-terminal amino acid. By blocking the interaction of spike protein with ACE2, the SARS-CoV-2 entry into the host cell and internalization can be avoided. The pathogenicity of SARS-CoV-2 could be reduced by preventing the RBD from attaching to ACE2-expressing cells. Therefore, inhibition or down-regulation of ACE2 in host cells represents a therapeutic strategy to fight against COVID-19. However, ACE2 plays an essential role in the physiological pathway, protecting against hypertension, heart failure, myocardial infarction, acute respiratory lung disease, and diabetes. Given the importance of ACE's homeostatic role, targeting of ACE2 should be realized with caution. Above all, focusing on the SARS-CoV-2 spike protein and the ACE2 gene in the host cell is an excellent way to avoid viral mutation and resistance. The current review summarises the sequence analysis, structure of coronavirus, ACE2, spike protein-ACE2 complex, essential structural characteristics of the spike protein RBD, and ACE2 targeted approaches for anti-coronaviral drug design and development.
Pengaruh Penambahan Waste Glass sebagai Agregat Kasar terhadap Kuat Tekan Beton
Authors: Utami Sri Rejeki Laku , Zaini Muh , Hidayat Adib Wajyu 
Published: February 2022

ABSTRACTThis research aims to utilize glass waste as the basic material of coarse aggregate in the concrete mix used to reduce glass waste. This research uses 15 specimens with 150 x 300 mm in dimensions. The test results of normal concrete (BN) at 7, 14, and 28 days were 20.95 N/mm, 28.31 N/mm, and 34.54 N/mm. The BWG 1 at 7, 14, and 28 days was 24.35 N/mm, 25.48 N/mm, and 33.97 N/mm. BWG2 at 7, 14, and 28 days of 17.55 N/mm², 23.78 N/mm, and 29.44 N/mm. Waste glass (BWG3) at 7, 14, and 28 days of 20.38 N/mm², 20.95 N/mm, and 26.04 N/mm. BWG4 at 7, 14, and 28 were 13.02 N/mm, 19.82 N/mm, and 22.08 N/mm. Comparison of the compressive strength of normal concrete with waste glass concrete at the age of 7 days showed that BWG1 increased around 16%. As for other test specimens, there was a decrease in compressive strength compared to BN were the results for BW2, BW3, BW4 (16%, 3%, and 38%). At 14 days shows that the BWG1, BWG2, BWG3, and BWG4 decrease by 10%, 16%, 26%, and 30%. At 28 days showed the BWG1, BWG2, BWG3, and BWG4 decrease of 2%, 15%, 25%, and 36% compared to BN. ABSTRAKPenelitian ini bertujuan untuk memanfaatkan limbah kaca sebagai bahan dasar agregat kasar dalam campuran beton yang digunakan untuk mereduksi limbah kaca. Penelitian ini menggunakan 15 benda uji dengan dimensi 150 x 300 mm. Hasil pengujian beton normal (BN) pada umur 7, 14, dan 28 hari adalah 20,95 N/mm, 28,31 N/mm, dan 34,54 N/mm. BWG 1 pada hari ke 7, 14, dan 28 adalah 24,35 N/mm, 25,48 N/mm, dan 33,97 N/mm. BWG 2 pada 7, 14, dan 28 hari sebesar 17,55 N/mm², 23,78 N/mm, dan 29,44 N/mm. BWG 3 pada 7, 14, dan 28 hari sebesar 20,38 N/mm², 20,95 N/mm, dan 26,04 N/mm. BWG 4 pada 7, 14, dan 28 adalah 13,02 N/mm, 19,82 N/mm, dan 22,08 N/mm. Perbandingan kuat tekan beton normal dengan beton limbah kaca pada umur 7 hari menunjukkan bahwa BWG1 meningkat sekitar 16%. Sedangkan untuk benda uji lainnya terjadi penurunan kuat tekan dibandingkan dengan BN yaitu pada hasil BW2, BW3, BW4 (16%, 3%, dan 38%). Pada 14 hari menunjukkan bahwa BWG1, BWG2, BWG3, dan BWG4 mengalami penurunan sebesar 10%, 16%, 26%, dan 30%. Pada hari ke 28 menunjukkan penurunan BWG1, BWG2, BWG3, dan BWG4 sebesar 2%, 15%, 25%, dan 36% dibandingkan dengan BN.
Comparing the New Interdisciplinary Health in Work Intervention With Conventional Monodisciplinary Welfare Interventions at Norwegian Workplaces: Protocol for a Pragmatic Cluster Randomized Trial
Authors: Höper Anje Christina , Terjesen Christoffer Lilja , Fleten Nils 
Published: February 2022

Background
Musculoskeletal and mental health complaints are the dominant diagnostic categories in long-term sick leave and disability pensions in Norway. Continuing to work despite health complaints is often beneficial, and a good work environment can improve work inclusion for people affected. In 2001, the Norwegian Labour and Welfare Administration began to offer inclusive work measures to improve the psychosocial work environment and work inclusion of people with health complaints. In 2018, the Norwegian Labour and Welfare Administration and specialist health services started offering the new collaborative Health in work program. Its workplace intervention presents health and welfare information that may improve employees’ coping ability regarding common health complaints. It encourages understanding of coworkers’ health complaints and appropriate work adjustments to increase work participation.

Objective
This protocol presents an ongoing, 2-arm, pragmatic cluster-randomized trial. Its aim is to compare the effect of monodisciplinary inclusive work measures (treatment as usual) and interdisciplinary Health in work in terms of changes in overall sickness absence, health care use, health-related quality of life, and costs. The secondary objectives are to compare changes in individual sickness absence, psychosocial work environment, job and life satisfaction, health, and health anxiety at both the individual and group levels.

Methods
Data will be collected from national registers, trial-specific registrations, and questionnaires. Effects will be explored using difference-in-difference analysis and regression modeling. Multilevel analysis will visualize any cluster effects using intraclass correlation coefficients.

Results
Inclusion was completed in July 2021 with 97 workplaces and 1383 individual consents. Data collection will be completed with the last questionnaires to be sent out in July 2023.

Conclusions
This trial will contribute to filling knowledge gaps regarding the effectiveness and costs of workplace interventions, thereby benefiting health and welfare services, political decision makers, and the public and business sectors. The findings will be disseminated in reports, peer-reviewed journals, and conferences.

Trial Registration
ClinicalTrials.gov NCT04000035; https://clinicaltrials.gov/ct2/show/NCT04000035

International Registered Report Identifier (IRRID)
DERR1-10.2196/36166
“SCREENING ENFERMEDAD RENAL CRÓNICA EN PACIENTES DIABÉTICOS DE LARGA DE EVOLUCIÓN DE LA UMF (UNIDAD DE MEDICINA FAMILIAR) 222 “
Authors: Lopez lievanos Miguel angel 
Published: February 2022

RESUMEN
Autores.
*Dr. Guillermo Espinosa Fuentes/ *Dra. Yazmin Jocelyn Julian Hernández/ **Dr. Miguel Angel Lopez Lievanos /***Dra. María Guadalupe Berumen Lechuga.
*Médico Familiar. UMF No 222 **Médico Residente de la especialidad de Medicina Interna. Hospital General Regional 251 *** Coordinadora Auxiliar Médica de Investigación en Salud. Estado de México Poniente.
Introducción. La nefropatía diabética es la primera causa de enfermedad renal crónica en el mundo, sin embargo no existe información de la prevalencia de Enfermedad Renal Crónica (ERC) en estadios tempranos en México. Una tarea fundamental del primer nivel de atención es la detección oportuna de enfermedades. La ERC en pacientes diabéticos es subdiagnosticada en estadios tempranos al ser asintomática.
Objetivo. Determinar la frecuencia y estadificación de ERC en pacientes con diabetes mellitus tipo 2 de larga evolución en una unidad de primer nivel de atención, en el estado de México.
Material y Métodos: Estudio transversal descriptivo. Se incluyeron 263 pacientes calculado por fórmula de población finita y selección aleatoria simple. Se incluyeron pacientes con diabetes tipo 2, ? 5 años de evolución, sin encontrarse en terapia sustitutiva de la función renal que cumplieron los criterios de inclusión. Las variables de estudio: características sociodemográficas y la estimación de la tasa de filtración glomerular por la ecuación CKD-EPI fueron descritas en frecuencias y porcentaje para variables categóricas y las variables continuas se reportaron media y desviación estándar, la diferencia entre grupos fue establecida por medio de prueba de chi cuadrada o prueba exacta de Fisher, T de student de acuerdo al tipo de variable. Un valor de p ?0.05 fue considerado estadísticamente significativo
Resultados. La clasificación KDIGO presenta 5 estadios. Los resultados con respecto al grado de filtrado glomerular: estadio 1 con 39.5% (IC 95%, 34.2-45.6), estadio 2 con 38.8% (IC 95%, 32.7-44.5), estadio 3a con 8% (IC 95%, 4.9-11.4), estadio 3b con 5.7% (IC 95%, 3.4-8.7), estadio 4 con 6.8% (IC 95%, 3.8-9.9) y el estadio 5 con 1.1% (IC 95% 0.0-2.7). El promedio de edad fue 69.26 ±11.01 en el grupo con ERC, género masculino en el grupo con ERC con 59.6% y mujeres con 40.3%. Con respecto a comorbilidades, hipertensión arterial y tratamiento al analizarlas en grupos con ausencia de ERC y presencia de ERC fueron estadísticamente significativo, lo mismo en los resultados de laboratorio.
Conclusión. La prevalencia de ERC en nuestra población de estudio fue de 21%, es decir; al menos 1 de cada 5 pacientes diabéticos con 5 o más años de evolución padecen con algún grado de ERC. Los pacientes con factores de riesgo para ERC deben contar con una determinación de TFG al menos una vez al año. La fórmula recomendada es CKD-EPI.