bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ozone modified hypothalamic signaling enhancing thermogenesis in the TDP-43A315T transgenic model of Amyotrophic Lateral Sclerosis
Authors: Rodríguez-Sánchez Sara , Valiente Nicolas , Seseña Susana , Cabrera-Pinto Marta , Rodríguez Ana , Aranda Alfonso , Palop Llanos , Fernández-Martos Carmen M. 
Published: December 2022

AbstractAmyotrophic lateral sclerosis (ALS), a devastating progressive neurodegenerative disease, has no effective treatment. Recent evidence supports a strong metabolic component in ALS pathogenesis. Indeed, metabolic abnormalities in ALS correlate to disease susceptibility and progression, raising additional therapeutic targets against ALS. Ozone (O3), a natural bioactive molecule, has been shown to elicit beneficial effects to reduce metabolic disturbances and improved motor behavior in TDP-43A315T mice. However, it is fundamental to determine the mechanism through which O3 acts in ALS. To characterize the association between O3 exposure and disease-associated weight loss in ALS, we assessed the mRNA and protein expression profile of molecular pathways with a main role in the regulation of the metabolic homeostasis on the hypothalamus and the brown adipose tissue (BAT) at the disease end-stage, in TDP-43A315T mice compared to age-matched WT littermates. In addition, the impact of O3 exposure on the faecal bacterial community diversity, by Illumina sequencing, and on the neuromuscular junctions (NMJs), by confocal imaging, were analysed. Our findings suggest the effectiveness of O3 exposure to induce metabolic effects in the hypothalamus and BAT of TDP-43A315T mice and could be a new complementary non-pharmacological approach for ALS therapy.
Characterization and phylogenetic implications of newly sequenced mitogenomes of Five Mileewa and Processina species from China (Hemiptera: Cicadellidae: Mileewinae)
Authors: He Hongli , Yan Bin , Yu Xiaofei , Yang Maofa 
Published: December 2022

AbstractTo accumulate evidence of the phylogeny of Mileewinae and the relationships among Mileewa, Processina, and Ujna genera, we sequenced the complete mitochondrial genomes of four Mileewa spp., namely, Mileewa mira, Mileewa lamellata, Mileewa sharpa, and Mileewa amplimacula. The first complete mitogenome of the genus Processina (P. sexmaculata), established by Yang, Deitz & Li from China and comprising five species, was also sequenced in this study. Annotation showed that the five mitogenomes were 14787 –15436 bp in length, and all harbored 37 typical genes. The AT content of the five mitogenomes ranged from 78.3% to 80.2%, which was similar to that of other sequenced Mileewinae species. For protein-coding genes (PCGs), ATN was the start codon, while atp8 and nad5 genes were initiated with TTG, and a great majority of them used TAA or TAG as stop codons, whereas cox2 and nad1 ended with an incomplete codon T–. All tRNAs had a typical cloverleaf secondary structure, except for trnS1, which had a reduced dihydrouridine arm. We further used 59 Membracoidea species and two outgroups to reconstruct phylogenetic trees based on 13 PCGs under an independent partition model with Bayesian inference and Maximum-likelihood methods. Among these two trees, each of the subfamilies Cicadellinae, Typhlocybinae, and Mileewinae were recovered as a monophyletic group with high support values, suggesting that Typhlocybinae was more ancient than Mileewinae and Cicadellinae. Within the Mileewinae subfamily, all species maintained the same relationships and topologies according to both the BI and ML analyses (PP > 0.8, BS > 83) as follows: (M. sharpa + (U. puerana + ((M. ponta + (M. mira + M. lamellata)) + ((M. albovittata + (M. margheritae + M. amplimacula)) + (M. rufivena + (P. sexmaculata + M. alara)))))), and the monophyly of the genera Processina, Mileewa and Ujna were not supported. This study further enriches the Mileewinae mitogenome database and will contribute to future research on the systematics, evolution, and classification of this group.
A multifrequency characterization of the extragalactic hard X-ray sky
Authors: Kosiba M. , Peña-Herazo H. A. , Massaro F. , Masetti N. , Paggi A. , Chavushyan V. , Bottacini E. , Werner N. 
Published: December 2022

Context. Nowadays, we know that the origin of the cosmic X-ray background (CXB) is mainly due to the integrated emission of active galactic nuclei. Therefore, in order to obtain a precise estimate of the contribution of different source classes to the CXB, it is crucial to achieve full characterization of the hard-X ray sky.
Aims. We present a multifrequency analysis of all sources listed in the third release of the Palermo Swift-BAT hard X-ray catalog (3PBC) with the goal of (i) identifying and classifying the largest number of sources adopting multifrequency criteria, with particular emphasis on extragalactic populations and (ii) extracting sources belonging to the class of Seyfert galaxies to present here the release of the second version of the Turin-SyCAT.
Methods. We outline a classification scheme based on radio, infrared (IR), and optical criteria that allows us to distinguish between unidentified and unclassified hard X-ray sources, as well as to classify those sources belonging to the Galactic and the extragalactic populations.
Results. Our revised version of the 3PBC lists 1176 classified, 820 extragalactic, and 356 Galactic sources, as well as 199 unclassified and 218 unidentified sources. According to our analysis, the hard X-ray sky is mainly populated by Seyfert galaxies and blazars. For the blazar population, we report trends between the hard X-ray and the gamma-ray emissions based on the fact that a large fraction of them also have a counterpart detected by the Fermi satellite. These trends are all in agreement with the expectations of inverse Compton models which are widely adopted to explain the blazar broadband emission. For the Seyfert galaxies, we present the second version of the Turin-SyCAT, including a total of 633 Seyfert galaxies, with 282 new sources corresponding to an increase of ~80% with respect to the previous release. Comparing the hard X-ray and the infrared emissions of Seyfert galaxies, we confirm that there is no clear difference between the flux distribution of the infrared-to-hard X-ray flux ratio of Seyfert galaxies Type 1 and Type 2. However, there is a significant trend between the mid-IR flux and hard X-ray flux, confirming previous statistical results in the literature.
Conclusions. We provide two catalog tables. The first is the revised version of the 3PBC catalog based on our multifrequency analyses. The second catalog table is a release of the second version of the Turin-SyCAT catalog. Finally, we highlight that extensive soft X-ray data are already available in the form of the Swift archive which can be used to search for potential counterparts of unidentified hard X-ray sources. All these datasets will be reduced and analyzed in a forthcoming analysis to determine the precise position of low-energy counterparts in the 0.5–10 keV energy range for 3PBC sources that can be targets of future optical spectroscopic campaigns; this is necessary to obtain their precise classification.
Molecules in the peculiar age-defying source IRAS 19312+1950
Authors: Qiu Jian-Jie , Zhang Yong , Nakashima Jun-ichi , Zhang Jiang-Shui , Koning Nico , Tang Xin-Di , Yan Yao-Ting , Feng Huan-Xue 
Published: December 2022

Context. IRAS 19312+1950 is an isolated infrared source that exhibits a characteristic quasi-point-symmetric morphology in the near-and mid-infrared images and is also very bright in molecular radio lines. Because of its unique observational characteristics, various observational studies have been conducted and several hypotheses have been proposed regarding its origin, which is still unclear. So far, it has been suggested that it could be a peculiar evolved star, a young stellar object, or even a red nova remnant. Regardless of which type of object it is ultimately classified as, IRAS 19312+1950 is exceptionally bright in the infrared and molecular radio lines and therefore will undoubtedly be crucial as a prototype of this kind of object having a peculiar nature or unusual evolutionary phase.
Aims. This study aims to reveal the molecular composition of the central part of IRAS 19312+1950 by performing an unbiased molecular radio line survey and discussing the origin of the object from a molecular chemical point of view.
Methods. We carried out a spectral line survey with the Institut de Radioastronomie Millimtrique 30 m telescope towards the centre of IRAS 19312+1950 in the 3 and 1.3 mm windows with a frequency coverage of 83.9–91.8 and 218.2–226.0 GHz, respectively.
Results. In total, 28 transition lines of 22 molecular species and those isotopologues are detected towards IRAS 19312+1950, some of which exhibit a broad and a narrow component. Seventeen thermal lines and one maser line are newly detected. The molecular species of C17O, 30SiO, HN13C, HC18O+, H2CO, and c-C3H2 are detected for the first time in this object. We calculated the optical depths of the transition lines of 13CO, C18O, HCN, H13CN, and C2H, and determined the rotational temperatures, column densities, and fractional abundances of the detected molecules. We got the isotopic ratios of 12C/13C, 14N/15N, 16O/18O, 16O/17O, 18O/17O, 28Si/30Si, and 29Si/30Si in IRAS 19312+1950 and the values were compared to those of evolved stars, red novae, young stellar objects, and the Sun. The intensities of the molecular radio lines of IRAS 19312+1950 were compared with those of different categories of objects, indicating that the spectral pattern of the broad-line region is similar to that of a red nova or a low-mass young stellar object, while the narrow-line region behaves like an envelope of the asymptotic giant branch star.
Conclusions. Our results, in combination with previous studies, favour the hypothesis that IRAS 19312+1950 might be a red nova remnant, in which the progenitors that merged to become a red nova may have contained at least two evolved stars with oxygen-rich and carbon-rich chemistry, respectively.
Kutane Plattenepithelkarzinome im Kopf- und Halsbereich
Authors: Deutsch Jochen , Dippel Edgar , Delank K.-Wolfgang 
Published: December 2022

Zusammenfassung
Hintergrund Das kutane Plattenepithelkarzinom (kPEK) als weltweit zweithäufigster Hauttumor ist überwiegend an Kopf und Gesicht lokalisiert. Aufgrund der steigenden Anzahl älterer Menschen und der dadurch zunehmenden Inzidenz gewinnt es in den letzten Jahren an Relevanz im HNO-Fachgebiet.
Material und Methoden Diese Übersichtsarbeit basiert auf einer selektiven Literaturrecherche in PubMed, der deutschen und europäischen Leitlinie sowie klinikeigenen Erfahrungen.
Ergebnisse Ätiologisch ist neben der chronischen UV-Exposition eine Störung des körpereigenen Abwehrsystems zunehmend bedeutend. Die vertikale Tumordicke ist mit dem höchsten Risiko einer Metastasierung und eines Lokalrezidivs assoziiert. Weitere bedeutende Risikofaktoren sind: horizontaler Tumordurchmesser, Entdifferenzierung, Desmoplasie, perineurales Wachstum und Lokalisation im Gesicht. Zumeist ist die Exzision mit histologischer Schnittrandkontrolle als Therapie ausreichend. Bei klinischem Verdacht auf lokoregionäre Metastasen sollen je nach Lokalisation des Primärtumors die drainierenden zervikalen Lymphknotenlevel ausgeräumt werden. kPEK der oberen Gesichtshaut und der Ohrmuschel metastasieren bevorzugt zuerst in die Glandula parotidea. Mit der Zulassung des PD-1-Antikörpers Cemiplimab in Europa steht erstmals ein Wirkstoff zur Behandlung fortgeschrittener, chirurgisch oder durch Strahlentherapie nicht therapierbarer kPEK zur Verfügung.
Schlussfolgerungen Die grundsätzlich sehr niedrige Mortalität des kPEK erhöht sich erheblich, wenn Metastasen auftreten. Dementsprechend sollen sich bildgebende Verfahren, chirurgische Therapie und Nachsorgeintervalle an den Risikofaktoren orientieren. Hierdurch können Metastasen oder Lokalrezidive frühzeitig erkannt und die Prognose verbessert werden.
Vergangenheit verstehen hilft Zukunt denken:
Psychiatrie-Reformgeschichte in Großbritannien und
Italien
Authors: Becker Thomas , Schomerus Georg , Speerforck Sven 
Published: December 2022

ZusammenfassungDie Psychiatriereformen Großbritanniens und Italiens wurden viel
diskutiert. Kürzliche Publikationen erlauben eine vergleichende
Reflektion. In England begann der Prozess früher, erfolgte
kontinuierlich, in den letzten Jahrzehnten wurden die Komponenten
Deinstitutionalisierung und gemeindepsychiatrische Ausrichtung durch
Nutzerbeteiligung, Management, Evidenzbasierte Medizin und Leitlinien sowie
Budgetkürzungen ergänzt. Die Paradigmen jeweiligen
Regierungshandelns sind erkennbar. In Italien begann der Reformprozess
später, verlief disruptiver, war durch Basaglia und eine
poltisch-zeitgeschichtliche Konstellation geprägt. Die italienische
Reform zeigt Kontinuität, Defizite werden diskutiert, die Reform hat
sich historisch bewährt. Gemeinsamkeiten und Unterschiede (GB vs I)
werden verdeutlicht, eine sozialgeschichtliche Einordnung wird vorgeschlagen, um
psychiatrische Reformen als Teil von Vergesellschaftungsprozessen zu begreifen.
Dies ist wichtig, um Allianzen zur Weiterentwicklung psychiatrischer Versorgung
identifizieren und gestalten zu können.
Electronic, vibrational, and rotational analysis of 1,2-benzanthracene by high-resolution spectroscopy referenced to an optical frequency comb
Authors: Katori Toshiharu , Kunishige Sachi , Baba Masaaki , Nakayama Naofumi , Ishimoto Takayoshi , Nishiyama Akiko , Yamasaki Sho , Misono Masatoshi 
Published: December 2022

The electronic and vibrational structures of 1,2-benzanthracene-h12 (aBA-h12) and 1,2-benzanthracene-d12 (aBA-d12) were elucidated by analyzing fluorescence excitation spectra and dispersed fluorescence spectra in a supersonic jet on the basis of DFT calculation. We also observed the high-resolution and high-precision fluorescence excitation spectrum of the S1←S0000 band, and determined the accurate rotational constants in the zero-vibrational levels of the S0 and S1 states. In this high-resolution measurement, we used a single-mode UV laser whose frequencies were controlled with reference to an optical frequency comb. The inertial defect is negligibly small, the molecule is considered to be planar, and the obtained rotational constants were well reproduced by the equation-of-motion coupled cluster singles and doubles (EOM-CCSD) calculation. Both a-type and b-type transitions are found to be included in the rotationally resolved spectrum, and the a-type contribution is dominant, that is, the transition moment is nearly parallel to the long axis of the aBA molecule. We concluded that the S1 state is mainly composed of the Φ(B) configuration. The observed fluorescence lifetime (106 ns) is considerably longer than that of the Φ(A) system, such as anthracene (18 ns). The transition moment for the lower state of mixed states becomes small, reflecting a near-cancelation of the contributions from the parts of the wavefunction corresponding to the two electronic configurations. The bandwidth of the S2 ← S0 transition is large, and the structure is complicated. It is attributed to vibronic coupling with the high vibrational levels of the S1 state.
“I learned it on the job”
Authors: Esteves Salomé , Neves Marco 
Published: December 2022

Abstract
Graphs, charts, and infographics have long been a part of newsrooms. Nevertheless, in recent decades, new data
processing and graphical representation findings have led to a boom in data and visual journalism. Both professionals and
newsrooms have had to adapt quickly to the fast-developing field of Data Visualization while facing an unprecedented crisis.
Through semi-structured interviews with worldwide graphic reporters and data journalists, this research delves into academic
backgrounds, daily tasks, and design processes to answer the question of how someone comes to design graphics for a living in recent
years. One common phenomenon was identified: self-teaching.
Sin noticias del chabacano
Authors: Fernández Mauro , Vázquez-Veiga Nancy 
Published: December 2022

Abstracta
En un artículo reciente se ha argumentado que todas las variedades del chabacano proceden de una inicial, forjada
antes de 1640 como instrumento de comunicación interétnica. Tal propuesta incluye un rechazo explícito del argumento ex
silentio – utilizado por otros autores para defender una formación más tardía – ya que en ninguna de las áreas en las
que surgieron criollos hay evidencia de nada. Si hubiese muchos testimonios sobre el uso de las lenguas en el siglo XVII en las
zonas que posteriormente hablaron chabacano y ninguno pudiese interpretarse como referido al criollo, añaden los autores de la
nueva hipótesis, entonces el argumento ex silentio sí merecería ser tomado en serio. En el presente trabajo se
aportan diversas noticias sobre la comunicación interlingüística en Manila y Cavite antes de 1640. Como ninguna de ellas contiene
nada que pueda interpretarse como referencia al chabacano, el argumento ex silentio bien merece ser tomado en
consideración.
Scalar correlators and normal modes in holographic neutron stars
Authors: Canavesi Tobías , Fierro Octavio , Grandi Nicolás , Pisani Pablo 
Published: December 2022

Abstract
The holographic neutron star provides a strong coupling description for a highly degenerate metallic state on a sphere. Its phase space can be split into two different sectors, with an unstable region at intermediate degeneracies. We investigate the critical nature of such region, by analyzing the asymptotic behavior of a scalar probe to compute the two-point correlator of the boundary theory. We show that in the stable region the correlator is dominated by the normal modes, whereas it displays a critical power-law behavior as we move into the unstable region.
Weakly isolated horizons: 3

+

1 decomposition and canonical formulations in self-dual variables
Authors: Corichi Alejandro , Reyes Juan D , Vukašinac Tatjana 
Published: December 2022

Abstract
The notion of Isolated Horizons has played an important role in gravitational physics, being useful from the characterization of the endpoint of black hole mergers to (quantum) black hole entropy. In particular, the definition of weakly isolated horizons (WIHs) as quasilocal generalizations of event horizons is purely geometrical, and is independent of the variables used in describing the gravitational field. Here we consider a canonical decomposition of general relativity in terms of connection and vierbein variables starting from a first order action. Within this approach, the information about the existence of a (weakly) isolated horizon is obtained through a set of boundary conditions on an internal boundary of the spacetime region under consideration. We employ, for the self-dual action, a generalization of the Dirac algorithm for regions with boundary. While the formalism for treating gauge theories with boundaries is unambiguous, the choice of dynamical variables on the boundary is not. We explore this freedom and consider different canonical formulations for non-rotating black holes as defined by WIHs. We show that both the notion of horizon degrees of freedom and energy associated to the horizon is not unique, even when the descriptions might be self-consistent. This represents a generalization of previous work on isolated horizons both in the exploration of this freedom and in the type of horizons considered. We comment on previous results found in the literature.
Detecting nonclassicality and non-Gaussianity of a coherent superposed quantum state
Authors: Deepak  , Chatterjee Arpita 
Published: December 2022

Abstract
In this paper, we investigate the nonclassicality and non-Gaussianity of a coherent superposed quantum state (CSQS) which is obtained by applying a coherent superposition of field annihilation (a) and creation (

a
†

) operators,

N
(
t
a
+
r

a
†

)

to a classical coherent state

|
α
⟩

, where t and r are scalars with

t
2

+

r
2

=
1

. Such an operation, when applied on states having classical characters, introduces strong nonclassicality. We use different criteria to check the nonclassicality and non-Gaussianity of the considered quantum state. We first compute the Wigner function of CSQS. To study the nonclassicality of the considered state we further use (a) linear entropy (b) Wigner logarithmic negativity and (c) skew information based measure. Relative entropy based measure is considered to analyze the variation in non-Gaussianity of CSQS. Finally, the dynamics of the Wigner function evolving under the photon loss channel is addressed to probe the effect of noise on nonclassicality as well as non-Gaussianity of CSQS.
Dual-band absorber using low-profile multi-mode resonant units for controllable bandwidths
Authors: Huang Shengxiang , Wu Yueyang , Deng Lianwen , Qiu Lei-Lei 
Published: December 2022

Abstract
A dual-band quasi-single-layer absorber based on multimode resonance is proposed. Different from the traditional multi-substrate or multi-resonator composite structure, by virtue of stub- and slot-loaded technologies, only one single-substrate printed resonator is utilized to achieve multi-mode resonant characteristics for two absorption bands. The bandwidth of the two absorption bands can be adjusted by structural parameters. Through the detailed analysis of the surface current distribution in different modes, the generation principle of the multi-mode dual-band characteristic is revealed. Finally, the dual-band absorber is fabricated and measured, achieving dual-band absorptions in the frequency range of 7.64–10.8 GHz and 15.04–17.32 GHz with fractional bandwidth of 34.3% and 14.1%, respectively. The advantages of low-profile simple structure and controlled dual bandwidth make it very suitable for radar detection and stealth fields.
The modulation of electrothermal distribution by square spiral kirigami structure in graphite paper
Authors: Jingye Gao , Yinglin Qin , Bojun Yang , Chang Wang , Anzuo Qin , Si Xiao , Jun He 
Published: December 2022

Abstract
A square spiral incision was introduced into a 15 × 15 cm regular quadrilateral conductive film to study the modulation of electrothermal distribution by kirigami structure. Based on the simulation of finite element method, the transition from thermal focusing to thermal defocusing could be achieved by increasing the length of connection between adjacent modules. The effective electrothermal area can be increased by nearly two times through increasing the length increment of the notch length between adjacent modules. The maximum temperature was decreased from 254 °C to 44 °C, and the temperature difference was adjusted from 76 °C to 4 °C by increasing the number of kirigami module. Through the contact temperature measurement experiment on graphite paper kirigami structure, the trends could be verified. By creating an equivalent circuit model and considering the influence of heat conduction, the peak temperature at the center of the structure and the decrease of the overall temperature could be explained. By deriving the relationship between the temperature of conductive film of kirigami structure with time and position, the electrothermal characteristics of previously reported graphene kirigami structure could be predicted.