bluuebunny/crossref_metadata_2025_split huggingface dataset:
Intention to vaccinate against COVID-19 and adherence to non-pharmaceutical interventions against COVID-19 prior to the second wave of the pandemic in Uganda: a cross-sectional study
Authors: Wafula Solomon Tsebeni , Mugume Innocent B , Sensasi Benjamin , Okware Solome , Chimbaru Alexander , Nanyunja Miriam , Talisuna Ambrose , Kabanda Richard , Bakyaita Tabley , Wanyenze Rhoda K , Byakika-Tusiime Jayne 
Published: June 2022

ObjectivesThe resurgence in cases and deaths due to COVID-19 in many countries suggests complacency in adhering to COVID-19 preventive guidelines. Vaccination, therefore, remains a key intervention in mitigating the impact of the COVID-19 pandemic. This study investigated the level of adherence to COVID-19 preventive measures and intention to receive the COVID-19 vaccine among Ugandans.Design, setting and participantsA nationwide cross-sectional survey of 1053 Ugandan adults was conducted in March 2021 using telephone interviews.Main outcome measuresParticipants reported on adherence to COVID-19 preventive measures and intention to be vaccinated with COVID-19 vaccines.ResultsOverall, 10.2% of the respondents adhered to the COVID-19 preventive guidelines and 57.8% stated definite intention to receive a SARS-CoV-2 vaccine. Compared with women, men were less likely to adhere to COVID-19 guidelines (Odds Ratio (OR)=0.64, 95% CI 0.41 to 0.99). Participants from the northern (4.0%, OR=0.28, 95% CI 0.12 to 0.92), western (5.1%, OR=0.30, 95% CI 0.14 to 0.65) and eastern regions (6.5%, OR=0.47, 95% CI 0.24 to 0.92), respectively, had lower odds of adhering to the COVID-19 guidelines than those from the central region (14.7%). A higher monthly income of ≥US$137 (OR=2.31, 95% CI 1.14 to 4.58) and a history of chronic disease (OR=1.81, 95% CI 1.14 to 2.86) were predictors of adherence. Concerns about the chances of getting COVID-19 in the future (Prevalence Ratio (PR)=1.26, 95% CI 1.06 to 1.48) and fear of severe COVID-19 infection (PR=1.20, 95% CI 1.04 to 1.38) were the strongest predictors for a definite intention, while concerns for side effects were negatively associated with vaccination intent (PR=0.75, 95% CI 0.68 to 0.83).ConclusionBehaviour change programmes need to be strengthened to promote adherence to COVID-19 preventive guidelines as vaccination is rolled out as another preventive measure. Dissemination of accurate, safe and efficacious information about the vaccines is necessary to enhance vaccine uptake.
Cohort profile: the multigeneration Respiratory Health in Northern Europe, Spain and Australia (RHINESSA) cohort
Authors: Svanes Cecilie , Johannessen Ane , Bertelsen Randi Jacobsen , Dharmage Shyamali , Benediktsdottir Bryndis , Bråbäck Lennart , Gislason Thorarinn , Holm Mathias , Jõgi Oskar , Lodge Caroline J , Malinovschi Andrei , Martinez-Moratalla Jesus , Oudin Anna , Sánchez-Ramos José Luis , Timm Signe , Janson Christer , Real Francisco Gomez , Schlünssen Vivi 
Published: June 2022

PurposeThe Respiratory Health in Northern Europe, Spain and Australia (RHINESSA) cohort was established to (1) investigate how exposures before conception and in previous generations influence health and disease, particularly allergies and respiratory health, (2) identify susceptible time windows and (3) explore underlying mechanisms. The ultimate aim is to facilitate efficient intervention strategies targeting multiple generations.ParticipantsRHINESSA includes study participants of multiple generations from ten study centres in Norway (1), Denmark (1), Sweden (3), Iceland (1), Estonia (1), Spain (2) and Australia (1). The RHINESSA core cohort, adult offspring generation 3 (G3), was first investigated in 2014–17 in a questionnaire study (N=8818, age 18–53 years) and a clinical study (subsample, n=1405). Their G2 parents participated in the population-based cohorts, European Community Respiratory Heath Survey and Respiratory Health In Northern Europe, followed since the early 1990s when they were 20–44 years old, at 8–10 years intervals. Study protocols are harmonised across generations.Findings to dateCollected data include spirometry, skin prick tests, exhaled nitric oxide, anthropometrics, bioimpedance, blood pressure; questionnaire/interview data on respiratory/general/reproductive health, indoor/outdoor environment, smoking, occupation, general characteristics and lifestyle; biobanked blood, urine, gingival fluid, skin swabs; measured specific and total IgE, DNA methylation, sex hormones and oral microbiome. Research results suggest that parental environment years before conception, in particular, father’s exposures such as smoking and overweight, may be of key importance for asthma and lung function, and that there is an important susceptibility window in male prepuberty. Statistical analyses developed to approach causal inference suggest that these associations may be causal. DNA methylation studies suggest a mechanism for transfer of father’s exposures to offspring health and disease through impact on offspring DNA methylation.Future plansFollow-up is planned at 5–8 years intervals, first in 2021–2023. Linkage with health registries contributes to follow-up of the cohort.
Glucocorticoid discontinuation in patients with SLE with prior severe organ involvement: a single-center retrospective analysis
Authors: Nakai Takehiro , Fukui Sho , Ikeda Yukihiko , Suda Masei , Tamaki Hiromichi , Okada Masato 
Published: June 2022

ObjectiveLong-term glucocorticoid use in SLE may have significant side effects; however, glucocorticoid discontinuation is occasionally associated with disease flare-ups. Therefore, we evaluated the risk factors for disease flares and the flare rate on glucocorticoid tapering in patients with prior severe organ involvement.MethodsData of patients with SLE with glucocorticoid tapering at our institution were retrospectively analysed. We divided the patients by the presence of prior severe organ involvement and compared flare rates after glucocorticoid discontinuation. Furthermore, we determined risk factors for flares after glucocorticoid discontinuation.ResultsIn total, 309 patients with SLE were screened, 73 of whom met the inclusion criteria; 49 were classified as SLE with prior severe organ involvement. No significant differences were noted in the 52-week flare rate after glucocorticoid discontinuation between patients with and without prior severe organ involvement (16.7% vs 18.2%, p=1.0). Hypocomplementaemia, elevated anti-dsDNA antibody titres more than twice the upper limit of the laboratory reference range, positive anti-Smith/anti-ribonucleoprotein antibody, and use of any immunosuppressant on the day of glucocorticoid discontinuation were negatively associated with flare-free remission.ConclusionsGlucocorticoid discontinuation after gradual tapering can often be achieved in patients with SLE, even with prior severe organ involvement, especially when the disease is clinically and serologically stable.
Effects of diet on the outcomes of rheumatic and musculoskeletal diseases (RMDs): systematic review and meta-analyses informing the 2021 EULAR recommendations for lifestyle improvements in people with RMDs
Authors: Gwinnutt James M , Wieczorek Maud , Rodríguez-Carrio Javier , Balanescu Andra , Bischoff-Ferrari Heike A , Boonen Annelies , Cavalli Giulio , de Souza Savia , de Thurah Annette , Dorner Thomas E , Moe Rikke Helene , Putrik Polina , Silva-Fernández Lucía , Stamm Tanja , Walker-Bone Karen , Welling Joep , Zlatković-Švenda Mirjana , Guillemin Francis , Verstappen Suzanne M M 
Published: June 2022

BackgroundA EULAR taskforce was convened to develop recommendations for lifestyle behaviours in rheumatic and musculoskeletal diseases (RMDs). In this paper, the literature on the effect of diet on the progression of RMDs is reviewed.MethodsSystematic reviews and meta-analyses were performed of studies related to diet and disease outcomes in seven RMDs: osteoarthritis (OA), rheumatoid arthritis (RA), systemic lupus erythematosus, axial spondyloarthritis, psoriatic arthritis, systemic sclerosis and gout. In the first phase, existing relevant systematic reviews and meta-analyses, published from 2013 to 2018, were identified. In the second phase, the review was expanded to include published original studies on diet in RMDs, with no restriction on publication date. Systematic reviews or original studies were included if they assessed a dietary exposure in one of the above RMDs, and reported results regarding progression of disease (eg, pain, function, joint damage).ResultsIn total, 24 systematic reviews and 150 original articles were included. Many dietary exposures have been studied (n=83), although the majority of studies addressed people with OA and RA. Most dietary exposures were assessed by relatively few studies. Exposures that have been assessed by multiple, well conducted studies (eg, OA: vitamin D, chondroitin, glucosamine; RA: omega-3) were classified as moderate evidence of small effects on disease progression.ConclusionThe current literature suggests that there is moderate evidence for a small benefit for certain dietary components. High-level evidence of clinically meaningful effect sizes from individual dietary exposures on outcomes in RMDs is missing.
Effect of tofacitinib on pain, fatigue, health-related quality of life and work productivity in patients with active ankylosing spondylitis: results from a phase III, randomised, double-blind, placebo-controlled trial
Authors: Navarro-Compán Victoria , Wei James Cheng-­Chung , Van den Bosch Filip , Magrey Marina , Wang Lisy , Fleishaker Dona , Cappelleri Joseph C , Wang Cunshan , Wu Joseph , Dina Oluwaseyi , Fallon Lara , Strand Vibeke 
Published: June 2022

BackgroundAnkylosing spondylitis (AS) impacts quality of life. We assessed patient-reported outcomes (PROs), pain, fatigue, health-related quality of life (HRQoL) and work productivity in a phase III trial of tofacitinib.MethodsAdults with AS and with inadequate response/intolerance to ≥2 non-steroidal anti-inflammatory drugs received tofacitinib 5 mg twice daily or placebo for 16 weeks. Afterwards, all received open-label tofacitinib until week 48. Change from baseline to week 48 was determined for PROs: total back pain; nocturnal spinal pain; Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) overall spinal pain (Q2); Functional Assessment of Chronic Illness Therapy-Fatigue; BASDAI fatigue (Q1); AS Quality of Life (ASQoL); Short Form-36 Health Survey Version 2 (SF-36v2); EuroQoL-Five Dimension-Three Level health profile and Visual Analogue Scale; and the Work Productivity and Activity Impairment (WPAI) questionnaire. Improvements from baseline ≥minimum clinically important difference, and scores ≥normative values at week 16 were evaluated.ResultsIn 269 randomised and treated patients, at week 16, there were greater least squares mean improvements from baseline with tofacitinib 5 mg twice daily versus placebo in BASDAI overall spinal pain (–2.85 vs –1.34), BASDAI fatigue (–2.36 vs –1.08), ASQoL (–4.03 vs –2.01) and WPAI overall work impairment (–21.49 vs –7.64) (all p<0.001); improvements continued/increased to week 48. Improved spinal pain with tofacitinib was seen by week 2. Patients receiving tofacitinib reported clinically meaningful PRO improvements at week 16. Percentages with PRO scores ≥normative values at week 16 were greater with tofacitinib in SF-36v2 Physical Component Summary, physical functioning and bodily pain domains (p≤0.05).ConclusionsIn patients with AS, treatment with tofacitinib 5 mg twice daily resulted in clinically meaningful improvements in pain, fatigue, HRQoL and work productivity versus placebo to week 16, which were sustained to week 48.Trial registration numberNCT03502616.
Surface temperature inversion characteristics in dissimilar valleys, Yukon Canada
Authors: Noad Nick C. , Bonnaventure Philip P. 
Published: June 2022

Permafrost distribution in high-latitude continental mountains is a product of both latitudinal and elevationally controlled attributes. Frequently occurring surface-based temperature inversions (SBIs) significantly modify surface lapse rates (SLRs) annually. We aim to identify and quantify patterns of SBI characteristics in two proximal yet morphologically and vegetatively dissimilar central Yukon valleys. Elevational transect analysis is applied by using sensors in valley bottoms and 100 m upslope to determine in situ SLRs for the study period (August 2017 – August 2021). SLRs were shown to vary significantly between these dissimilar valleys. Climate reanalysis products (ClimateNA and Globsim) underestimated or almost entirely missed the presence of strong SBIs which produce annual average SLRs that range from 0.46 to 1.2 °C 100 m−1. The magnitude of these hyper-inversions was grossly underpredicted by previous surface air temperature modelling that attempted to account for SBIs across Yukon. Our results support the previously conceptualized framework that strong SBIs influence surface air temperatures and the pattern of permafrost distribution.
Beware of scaling artefacts and implicit model characteristics when fitting soil water release and moisture capacity data
Authors: Reynolds W. Daniel , Drury Craig F. 
Published: June 2022

The primary objectives of this study were to: ( i) elucidate the impacts of nonlinear scale transformations on the shapes and parameter values of soil water release and moisture capacity curves; and ( ii) demonstrate how implicit characteristics of some established soil water release and moisture capacity models can impact model-data fits and estimates of model parameters. Nonlinear scale transformations of the tension head ( h) axis (e.g., log10h, h1/2) were found to distort release and capacity curve shapes, create fictitious curve inflections and modes, and occasionally erase visual evidence of actual inflections and modes. The popular van Genuchten–Mualem and Assouline–Grant models were shown to always generate a release curve inflection and a capacity curve mode, even when inflections and modes did not exist in the data, and this in turn caused poor model-data fits in the critical near-saturated region. The van Genuchten model with four independently fitted parameters and the Dexter–Weibull model could accurately fit data sets with no inflection or mode, but this resulted in a physically unrealistic zero-angle intersection between the release curve and the water content axis. It was concluded that nonlinear h axis transforms should not be used when determining inflections, modes, pore size distributions, soil structure parameters, or soil quality indexes from soil water release and moisture capacity data-sets. It was also recommended that more flexible release curve models should be developed that do not assume the existence of inflections and modes, and also produce physically realistic angles of intersection between the water content axis and the fitted model.
Exact solution for accretion onto a moving charged dilaton black hole
Authors: Yang Rong-Jia , Jia Yinan , Jiao Lei 
Published: June 2022

AbstractWe present an analytic solution for accretion of a gaseous medium with adiabatic equation of state onto a charged dilaton black hole which moves at a constant velocity. We determine the four-velocity of accreted flow and find that it possesses axial symmetry. We obtain the particle number density and the accretion rate which depend on the mass, the magnetic charge, and the dilation of black hole, meaning that these parameters take important roles in the process of accretion. Possible theoretical and observational constraints on the parameter related to the dilation are discussed. The results may help us to get deeper understanding of the behavior of accreted flow near the event horizon of black hole.
Photometric Redshifts for Next-Generation Surveys
Authors: Newman Jeffrey A. , Gruen Daniel 
Published: June 2022

Photometric redshifts are essential in studies of both galaxy evolution and cosmology, as they enable analyses of objects too numerous or faint for spectroscopy. The Rubin Observatory, Euclid, and Roman Space Telescope will soon provide a new generation of imaging surveys with unprecedented area coverage, wavelength range, and depth. To take full advantage of these data sets, further progress in photometric redshift methods is needed. In this review, we focus on the greatest common challenges and prospects for improvement in applications of photometric redshifts to the next generation of surveys: ▪ Gains in performance (i.e., the precision of redshift estimates for individual galaxies) could greatly enhance studies of galaxy evolution and some probes of cosmology. ▪ Improvements in characterization (i.e., the accurate recovery of redshift distributions of galaxies in the presence of uncertainty on individual redshifts) are urgently needed for cosmological measurements with next-generation surveys.To achieve both of these goals, improvements in the scope and treatment of the samples of spectroscopic redshifts that make high-fidelity photometric redshifts possible will also be needed. For the full potential of the next generation of surveys to be reached, the characterization of redshift distributions must improve by roughly an order of magnitude compared with the current state of the art, requiring progress on a wide variety of fronts. We conclude by presenting a speculative evaluation of how photometric redshift methods and the collection of the necessary spectroscopic samples may improve by the time near-future surveys are completed.
Advances in the Study of Inhaled Formulations for the Treatment of Pulmonary Arterial Hypertension
Authors: Han Fei , Chen Yongqi , Li Shijie , Yang Yankun , Bai Zhonghu 
Published: June 2022

Pulmonary arterial hypertension (PAH) is a serious disease with reduced systemic circulation and low bioavailability associated with conventional and dosed therapy, which inhaled drugs can avoid. A mean pulmonary artery pressure (mPAP) of ≥25 mmHg (

1

mmHg
=
0.133

kPa

) at rest or ≥30 mmHg during exercise and a pulmonary capillary pressure or left atrial pressure (PLA) of ≤15 mmHg can be diagnosed with PAH. Pulmonary hypertension is classified into primary PAH and secondary PAH according to the presence or absence of principles or risk factors. The main symptoms of pulmonary hypertension include dyspnoea, syncope, weakness, chest pain, and the presence of varying degrees of peripheral oedema. It is a highly pathogenic and life-threatening disease and can lead to delays in treatment if not diagnosed in time. In the past few years, the studies related to this progressed slowly, which brought great harm to patients with PAH. Reports showed that patients diagnosed with PAH should receive routine preventative care, such as pneumococcal and influenza vaccinations. Inhalation therapy is mainly used for the treatment of respiratory diseases and is of great interest due to the concentration of the drug in the airways and lung tissues. Therefore, the present situation of pulmonary hypertension and the characteristics of inhalation preparation were reviewed in this paper to provide some related cue for the treatment of pulmonary hypertension. In the future, it is necessary to develop more treatment methods for pulmonary hypertension.
Time Trends for Incidence and Net Survival of Cervical Cancer in Sweden 1960–2014—A Nationwide Population-Based Study
Authors: Sundqvist Avalon , Moberg Louise , Dickman Paul W. , Högberg Thomas , Borgfeldt Christer 
Published: June 2022

Abstract

Background:
The aim was to investigate time trends for incidence and long-term net survival in the morphologic subtypes and stages of cervical cancer in Sweden during the period 1960 to 2014.

Methods:
Women with invasive cervical cancer were identified through the Swedish Cancer Registry. Incidence and net survival were calculated according to morphology, age at diagnosis, and FIGO stage at diagnosis.

Results:
In total, 29,579 cases of invasive cervical cancer between 1960 and 2014 were included. The age-standardized incidence for squamous cell carcinoma (SCC) decreased until 2000; thereafter, the incidence rate stagnated, and a small increase was found in 2014. The incidence of adenocarcinoma continuously increased. The age-standardized 5-year net survival increased. However, decreasing net survival with increasing age was found. A higher stage at diagnosis showed a worse net survival. SCC and adenocarcinoma did not statistically differ as regards net survival in the last years of the study.

Conclusions:
Age-standardized 5-year net survival improved between 1960 and 2014. A positive trend for short- and long-term net survival was seen for women ages 18 to 64 years but long-term net survival for women ≥75 years decreased. In this study, age and FIGO stage at diagnosis were found to be important prognostic factors in determining net survival. The morphologies, SCC, and adenocarcinoma did not statistically differ as regards net survival in the last years of the study.

Impact:
This study demonstrates longitudinal data on cervical cancer in Sweden for over 50 years with sub analyses on morphology, age, and stage at diagnosis.
Association of Abdominal Visceral Adiposity and Total Fat Mass with Cancer Incidence and Mortality in White and Black Adults
Authors: Katzmarzyk Peter T. , Brown Justin C. , Yang Shengping , Mire Emily F. , Wu Xiao-Cheng , Miele Lucio , Ochoa Augusto C. , Zabaleta Jovanny 
Published: June 2022

Abstract

Background:
Race modifies the association between anthropometric measures of obesity and cancer risk. However, the degree to which abdominal visceral adipose tissue (VAT) and total fat mass (FM) are associated with cancer risk is not known.

Methods:
The sample included 3,017 White and 1,347 Black adults who were assessed between 1995 and 2016 and followed for outcome assessment through 2017. Abdominal VAT and FM were measured using imaging techniques. The co-primary endpoints were diagnosis of histologically confirmed invasive cancer (excluding nonmelanoma skin cancer) or death from cancer. Multivariable Cox proportional hazards models quantified the HR of incident cancer and cancer mortality.

Results:
There were 353 incident cancer cases and 75 cancer deaths in an average of 12.9 years of follow-up. Both VAT [HR, 1.21; 95% confidence interval (CI), 1.09–1.36] and FM (HR, 1.25; 95% CI, 1.10–1.43) were significantly associated with incident cancer, while VAT (HR, 1.28; 95% CI, 1.01–1.61) was significantly associated with cancer mortality after adjustment for several covariates. VAT remained significantly associated with cancer incidence (HR, 1.22; 95% CI, 1.03–1.46) after additional inclusion of FM in the multivariable model, but not vice versa. There were no significant sex- or race-interactions.

Conclusions:
VAT was associated with risk of cancer and cancer mortality in this cohort, and the associations did not differ by sex or race. The association between VAT and incident cancer was largely independent of total FM.

Impact:
Our results suggest that utility of anthropometry in assessing obesity-related cancer risk may need to be further refined by including more direct measures of adiposity.