bluuebunny/crossref_metadata_2025_split huggingface dataset:
Rapid and Sequential Dual Oxime Ligation Enables De Novo Formation of Functional Synthetic Membranes from Water‐Soluble Precursors
Authors: Flores Judith , Brea Roberto J. , Lamas Alejandro , Fracassi Alessandro , Salvador‐Castell Marta , Xu Cong , Baiz Carlos R. , Sinha Sunil K. , Devaraj Neal K. 
Published: May 2022

AbstractCell membranes define the boundaries of life and primarily consist of phospholipids. Living organisms assemble phospholipids by enzymatically coupling two hydrophobic tails to a soluble polar head group. Previous studies have taken advantage of micellar assembly to couple single‐chain precursors, forming non‐canonical phospholipids. However, biomimetic nonenzymatic coupling of two alkyl tails to a polar head‐group remains challenging, likely due to the sluggish reaction kinetics of the initial coupling step. Here we demonstrate rapid de novo formation of biomimetic liposomes in water using dual oxime bond formation between two alkyl chains and a phosphocholine head group. Membranes can be generated from non‐amphiphilic, water‐soluble precursors at physiological conditions using micromolar concentrations of precursors. We demonstrate that functional membrane proteins can be reconstituted into synthetic oxime liposomes from bacterial extracts in the absence of detergent‐like molecules.
Enantioselective Synthesis of Atropisomeric Biaryl Phosphorus Compounds by Chiral‐Phosphonium‐Salt‐Enabled Cascade Arene Formation
Authors: Zhu Lixiang , Peng Heling , Guo Yan , Che Jixing , Wu Jia‐Hong , Su Zhishan , Wang Tianli 
Published: May 2022

AbstractAxially chiral biaryl monophosphorus molecules, exemplified by atropisomeric 1,1′‐biaryl aminophosphines, are significant motifs in numerous chiral ligands/catalysts. Developing efficient methods for preparing phosphorus compounds with these privileged motifs is an important endeavor in synthetic chemistry. Herein, we develop an effective, modular method by a chiral‐phosphonium‐salt‐catalyzed novel cascade between phosphorus‐containing nitroolefins and α,α‐dicyanoolefins, leading to a great diversity of atropisomeric biaryls bearing phosphorus groups in high yields with excellent stereoselectivities. The reaction features include a Thorpe‐type cycloaddition/oxidative hydroxylation/aromatization cascade pathway with a central‐to‐axial chirality transfer process. Insight gained from our studies is expected to advance general efforts towards the catalytic synthesis of atropisomeric biaryl phosphorus compounds, offering a platform for developing new efficient chiral ligands and catalysts.
Review on intrinsically recyclable flame retardant thermosets enabled through covalent bonds
Authors: Rashid Muhammad Abdur , Liu Wanshuang , Wei Yi , Jiang Qiuran 
Published: May 2022

AbstractDeveloping thermosets with inherent recyclability and flame retardancy is a great importance from the views of fire safety, resource conservation and environmental protection. Owing to their superior mechanical properties, versatility, outstanding adhesion‐ability, durability, thermal, and solvent stability comparable to conventional thermosets while demonstrating end‐of‐life reuse, recyclable thermosetting materials have gained much interest as an attractive class of sustainable thermosets. The chemical structure of thermosets includes dynamic covalent networks that provide durability and reprocessability. However, these recyclable thermosets possess significant flammability, limiting their application in automobiles, railways, aircraft, buildings, and electronic items. Thus, it is urgent to include them with flame retardants. The goal of this review paper is to give a broad understanding of the study by highlighting and discussing recent advances as well as future prospects for inherently recyclable flame retardant thermosets (RFRs). Moreover, synthesis methods have been highlighted to improve the design of internally recyclable fire retardant thermosets. A distinct emphasis will be given on the inherent RFRs in terms of flame retardancy, recycling property, physical properties, and thermal stability. Finally, we will explore the importance and threats that intrinsically recyclable flame retardant thermosets face in the future.
Mechanical properties of 3D printed micro‐nano rice husk/polylactic acid filaments
Authors: Sun Yufeng , Wang Yapeng , Mu Wenlong , Zheng Zipeng , Yang Bin , Wang Jinwei , Zhang Runkai , Zhou Kaiyuan , Chen Liang , Ying Jilai , Liu Xinping , Xu Guangyin 
Published: May 2022

AbstractIn this study, micro‐nano rice husks (MNRH) fibers are compounded in polylactic acid (PLA) to produce 3D‐printed filaments by using melt blending method, and some properties of the printed samples of different surface treatment processes are measured. Two silane coupling agents of KH550 and KH570 are severally used on MNRH and PLA to mitigate the surface quality deficiencies for an intimate interfacial bond. Microstructural analysis shows that the MNRH fibers of the composites treated by silane coupling agent have a better dispersing performance. Fourier transform infrared illustrates that the KH550 and KH570 are successfully grafted onto PLA and MNRH fibers. Thermogravimetric analysis (TGA/DSC) suggests that the thermostability and crystallinity of the composites treated by silane coupling agents are enhanced. Water absorption experiments shows that the water resistance of the composites is greatly increased by KH550 and KH570. In comparison with pure PLA, the tensile strength, tensile modulus, bending strength and bending modulus of the 6 wt.% MNRH/PLA composites that treated by KH550 and KH570 are enhanced by 83%, 98%, 54%, and 61%, respectively. The composites treated by KH550 and KH570 demonstrates the best performance, suggesting that they have great potential for use as an environmentally friendly alternative material in automotive interiors.
Enhanced thermal conductivity of epoxy acrylate/h‐BN and AlN composites by photo‐curing 3D printing technology
Authors: Lin Yucong , Deng Weijian , Rui Yueyue , Liu Yun , Lu Gang , Liu Jie 
Published: May 2022

AbstractFilling hexagonal boron nitride (h‐BN) is a hot topic in the research of improving the thermal conductivity of polymer composites. Conversely, its difficulty in dispersing and forming a three‐dimensional thermal network has become a major problem. This article uses liquid resin can effectively help the filler to be evenly dispersed and construct a multi‐layer connection network through 3D printing technology, which improves the thermal conductivity of polymer effectively. With the addition of 30 wt% h‐BN, the thermal conductivity of the epoxy acrylate (EA) composite reaches 1.60 Wm−1 K−1, which is 6.8 times that of pure epoxy acrylic resin. Our work provides a new idea for improving the thermal conductivity of photocured polymers.
Selective cytotoxicity of ent‐kaurene diterpenoids isolated from Baccharis lateralis and Baccharis retusa (Asteraceae)
Authors: Silva Matheus L. , Oliveira Cyntia S. , dos Santos Wagner J. O. , Oliveira Vani X. , Antar Guilherme M. , Lago João H. G. , Cerchiaro Giselle 
Published: May 2022

AbstractThis study presents the cytotoxic activity evaluation of the natural diterpenes ent‐kaurenoic acid (1) and its 15β‐hydroxy (2), 15β‐senecioyloxy (3), and 15β‐tiglinoyloxy (4) derivatives, isolated from Brazilian native plants, Baccharis retusa and B. lateralis (Asteraceae). Using the MTT (3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5‐diphenyltetrazolium bromide) colorimetric assay, it was observed that compound 1 displayed in vitro activity towards the aggressive MDA‐MB‐231 adenocarcinoma cell line and reduced toxicity against MCF‐10A nontumorigenic epithelial cells, indicating expressive selectivity. On the contrary, compounds 2–4 exhibited reduced toxicity and selectivity in both tested cell lines. Based on the chemical structures of compounds 1–4, it is suggested that the presence of additional functional groups at the C‐15 position—a hydroxyl group in compound 2 and isomeric isoprene units in compounds 3 and 4—might be responsible for the reduction in the potential/selectivity. In silico studies show, for compounds 1–4, good predictions regarding bioavailability and ADME (absorption, distribution, metabolism, and excretion) properties as well as no alerts for PAINS (pan‐assay structures interference). In conclusion, ent‐kaurenoic acid (1), a common diterpenoid isolated in high amounts from different plants belonging to the Baccharis genus, has been shown to be a promising cytotoxic agent against an aggressive adenocarcinoma cell line (MDA‐MB‐23) and, if well exploited, could be used as a scaffold in the development of molecular prototypes for the treatment of breast cancer.
Experimental and clinical evidence on the effect of carvacrol on respiratory, allergic, and immunologic disorders: A comprehensive review
Authors: Khazdair Mahammad R. , Ghorani Vahideh , Boskabady Mohammad H. 
Published: May 2022

AbstractCarvacrol (CAR) showed various pharmacological and therapeutic effects in different disorders. In the current article, the experimental and clinical effects of CAR on respiratory, allergic, and immunologic disorders are described. Various databases, including PubMed, Science Direct, and Scopus, were searched regarding the effects of CAR on respiratory and allergic disorders until the end of October 2021. CAR showed the relaxant effect, with various possible mechanisms suggesting the bronchodilatory effect in obstructive pulmonary diseases. The preventive effects of CAR on experimental animal models of respiratory diseases were shown through mechanisms such as antioxidant, immunomodulatory, and anti‐inflammatory. CAR also showed therapeutic potential on lung cancer, lung infections, and allergic and immunologic disorders. Clinical studies also revealed therapeutic effects of CAR on asthma, sulfur‐mustard‐induced lug disorders, and some other allergic and immunologic diseases. Pharmacological and therapeutic effects of CAR indicate possible remedy effects of this agent in the treatment of respiratory, allergic, and immunologic diseases.
Prognostic value of IGFBP2 in various cancers: a systematic review and meta‐analysis
Authors: Zhang Biao , Hong Chao‐Qun , Luo Yu‐Hao , Wei Lai‐Feng , Luo Yun , Peng Yu‐Hui , Xu Yi‐Wei 
Published: May 2022

AbstractBackgroundThe prognostic significance of insulin‐like growth factor binding protein 2 (IGFBP2) expression has been explored in plenty of studies in human cancers. Because of the controversial results, the meta‐analysis was carried out to evaluate the relevance of IGFBP2 expression with the prognosis in various tumors.MethodsThe data searched from four databases (Pubmed, Embase, Cochrane library, and Web of science) was used to calculate pooled hazard ratios (HRs) in this meta‐analysis. Subgroup analyses were stratified by ethnicity, cancer type, publication year, Newcastle–Ottawa Scale score, treatments, and populations.ResultsTwenty‐one studies containing 5560 patients finally met inclusion criteria. IGFBP2 expression was associated with lower overall survival (HR = 1.57, 95% CI = 1.31–1.88) and progression‐free survival (HR = 1.18, 95% CI = 1.04–1.34) in cancer patients, but not with disease‐free survival (HR = 1.50, 95% CI = 0.91–2.46) or recurrence‐free survival (HR = 1.50, 95% CI = 0.93–2.40). The subgroup analyses indicated IGFBP2 overexpression was significantly correlated with overall survival in Asian patients (HR = 1.42, 95% CI = 1.18–1.72), Caucasian patients (HR = 2.20, 95% CI = 1.31–3.70), glioma (HR = 1.36, 95% CI = 1.03–1.79), and colorectal cancer (HR = 2.52, 95% CI = 1.43–4.44) and surgery subgroups (HR = 1.97, 95% CI = 1.50–2.58).ConclusionThe meta‐analysis showed that IGFBP2 expression was associated with worse prognosis in several tumors, and may serve as a potential prognostic biomarker in cancer patients.
Case of follicular mucinosis showing brownish yellow and red dots via dermoscopy
Authors: Yamagishi Hiroki , Ota Mayumi , Nobeyama Yoshimasa , Asahina Akihiko 
Published: May 2022

AbstractWe herein describe a 68‐year‐old man with follicular mucinosis. A dermoscopic examination showed multiple, round, brownish yellow dots with a whitish rim in the follicular ostium and red dots in the interfollicular area. This case report is the first to suggest that follicular mucinosis shows these dermoscopic findings.
Application of laparoscopic distal pancreatectomy for normal anatomy after hiatal hernia repair: A case report
Authors: Yoneda Akira , Murakami Shunsuke , Tetsuo Hanako , Fukui Saeko , Miyoshi Takayuki , Okamoto Tatsuya , Kitasato Amane , Takeshita Hiroaki , Kuroki Tamotsu 
Published: May 2022

AbstractWe describe a case of pancreatic tumor associated with a giant type IV hiatal hernia that had prolapsed into the posterior mediastinum. Hiatal hernia repair should be performed first because it enables laparoscopic distal pancreatectomy to be performed in the normal anatomical position.
Determination of Primary Nucleation Kinetics of Acetylsalicylic Acid in Ethanol
Authors: Medina-Galván Xóchitl Montserrat , Quintana-Hernández Pedro Alberto , Fuentes-Cortés Luis Fabián , Martínez-González Gloria María 
Published: May 2022

AbstractThe metastable zone width (MSZW) for the acetylsalicylic acid‐ethanol system was determined by the polythermal method. Nucleation parameters were calculated applying the self‐consistent Nyvlt‐like approach and the classical three‐dimensional theory approach. The results showed the usual increments in MSZW with increases in the cooling rate, mixed effects when raising the agitation rates, and an unusual behavior that reduced MSZW when the saturation temperature decreased. The apparent nucleation order proved to be independent of all three analyzed variables. The interfacial energy increased with higher saturation temperature and activation energies incremented when agitation rates raised. In general, the two approaches explained closely the experimental results.
Toward Preeminent Throwing Power from a Novel Alkaline Copper Electronic Electroplating Bath with Composite Coordination Agents
Authors: Li Wei‐Qing , Jin Lei , Yang Jia‐Qiang , Wang Zhao‐Yun , Zhan Dongping , Yang Fang‐Zu , Tian Zhong‐Qun 
Published: May 2022

AbstractIn this work, an electronic copper electroplating bath with low copper ion concentration and preeminent throwing power in through hole (TH) thickening of the printed circuit board (PCB) was successfully developed. Based upon the weak alkaline bath containing the composite complexants of citrate (Cit) and ethylenediamine (En), their synergistic effects on the preeminent bath throwing power were carefully investigated and theoretically proved. The UV‐vis spectroscopy results illustrated that En exhibited a stronger coordination ability with Cu (II) ion than citrate, and the stoichiometric coordination ratio between En and Cu (II) ion was 2 : 1. The linear sweep voltammetry (LSV) results showed that the electro‐reduction peak potential of Cit−Cu coordination ion was −0.55 V (vs. Hg/HgO), whereas that of En−Cu ion was at a more negative potential of −0.82 V. The in situ Fourier transform infrared (FTIR) spectroscopy revealed that the adsorptions of the Cit−Cu and En−Cu coordination ions were potential dependent on the copper electrode. The Cit−Cu coordination ion was easily adsorbed at the interior sites of through holes with lower over‐potential to promote the growth of copper coating. Moreover, the En−Cu coordination ion adsorbed preferably on the surface and the edge of through hole for its higher electro‐reduction overpotential, to hinder the germinating of copper nuclear. The cross‐section observation of optical microscope proved that the throwing power of novel copper electroplating bath behaved surpassingly, up to 105.8 %.
How the Chalcogen Atom Size Dictates the Hydrogen‐Bond Donor Capability of Carboxamides, Thioamides, and Selenoamides
Authors: Nieuwland Celine , Fonseca Guerra Célia 
Published: May 2022

AbstractInvited for the cover of this issue are Celine Nieuwland and Célia Fonseca Guerra of the Vrije Universiteit Amsterdam. The image depicts how the increasing atom size of the chalcogen from O to S to Se elongates the carbon–chalcogen bond in amides due to the increase in the steric Pauli repulsion and thereby enhances the amide hydrogen‐bond donor strength. Read the full text of the article at 10.1002/chem.202200755.
Bubble Size Detection by Process Ancillaries
Authors: Hafner Lukas , Bäßler Robin , Schwarzer Steffen , Kley Markus , Dohnal Fadi 
Published: May 2022

AbstractThe production of liquid‐gas dispersions places high demands on the process technology, which requires knowledge of the bubble formation mechanisms, as well as the phase parameters of the media combinations used. To obtain the bubble sizes introduced to a flow not knowing the phase parameters, different process parameters are investigated. Their quality and applicability are evaluated. The results obtained make it possible to simplify long design processes of dispersion processes in manufacturing plants and to ensure the product quality of the products manufactured, by reducing waste.
Surface Modification of Porous Silica Particles with Carbohydrate Scaffolds as Receptor Components for Molecular Recognition
Authors: Uchida Tsukasa , Nakamura Ayano , Shimazaki Hannah , Kanie Yoshimi , Kanie Osamu 
Published: May 2022

AbstractInvited for this month's cover is the group of Osamu Kanie and co‐workers at Tokai University. The cover picture shows the interaction of an incoming molecule and a receptor surface as the first process of a molecular sensing mechanism. For this, porous silica particles were decorated with protected carbohydrates to create artificial pocket‐like structures on its surface. More information can be found in the Research Article by O. Kanie and co‐workers.
Is corporate social responsibility constrained by bank credit resource allocation?
Authors: Chen Qiao , Zeng Huixiang 
Published: May 2022

AbstractCredit rationing theory suggests that the impact of bank credit allocation on corporate social responsibility (CSR) has the dual effect of adverse selection and moral hazard. In this study, the impact of credit allocation on CSR and its mechanisms are explored in the context of credit rationing theory based on Chinese listed companies from 2010 to 2019. The results show that the impact of bank credit allocation on CSR exhibits an inverted U‐shaped correlation, and there is a critical point (17.9134) at which the increase in credit allocation will promote the level of CSR until the critical point is exceeded, after which the level of CSR will gradually decrease. Credit allocation can influence CSR through information asymmetry (stock price informativeness, analyst tracking) and managerial overconfidence, respectively. Companies with overconfident managers and low transparency in non‐socially responsible weighting systems are more likely to have an inverted U‐shaped relationship between bank credit allocation and CSR. This study provides new empirical evidence to understand the impact of credit allocation on CSR and expands the theory of credit rationing to a certain extent, thereby providing a reference for CSR maximization.
Cracking the cryptic code in amyotrophic lateral sclerosis and frontotemporal dementia: Towards therapeutic targets and biomarkers
Authors: Akiyama Tetsuya , Koike Yuka , Petrucelli Leonard , Gitler Aaron D. 
Published: May 2022

AbstractAmyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are two devastating human neurodegenerative diseases. A hallmark pathological feature of both diseases is the depletion of the RNA‐binding protein TDP‐43 from the nucleus in the brain and spinal cord of patients. A major function of TDP‐43 is to repress the inclusion of cryptic exons during RNA splicing. When it becomes depleted from the nucleus in disease, this function is lost, and recently, several key cryptic splicing targets of TDP‐43 have emerged, including STMN2, UNC13A, and others. UNC13A is a major ALS/FTD risk gene, and the genetic variations that increase the risk for disease seem to do so by making the gene more susceptible to cryptic exon inclusion when TDP‐43 function is impaired. Here, we discuss the prospects and challenges of harnessing these cryptic splicing events as novel therapeutic targets and biomarkers. Deciphering this new cryptic code may be a touchstone for ALS and FTD diagnosis and treatment.
Turning eating disorders screening in primary practice into treatment: A clinical practice approach
Authors: Wade Tracey D. , Johnson Catherine , Cadman Kath , Cook Lesley 
Published: May 2022

AbstractObjectiveThe rate of screening for eating disorders (EDs) by general practitioners (GPs) in primary health care is low. We examined an approach to increase screening and the impact on referrals.MethodLow cost assessment/treatment pathways were established in February 2019 for patients with an ED. Between October 2020 and June 2021 information was sent to GP practices about screening for EDs, along with provision of an online screening tool and training.ResultsOf the 44 GP practices invited to participate in the screening initiative, 42 (95.5%) agreed. Only 12 (27%) had referred patients before the initiative, 53 patients over 19 months (2.8/month). Over the 10‐month initiative 90 patients were referred and started treatment from 50% of the practices (8.2/month); 73 (81%) had an ED and six had disordered eating but not an ED. Qualitative feedback from GPs suggested they would not screen for a condition if there were no readily identifiable treatment pathway available.DiscussionResults suggest that the three elements of the initiative (provision of assessment and treatment pathways, access to a screening tool, provision of information on screening) increased the likelihood that GPs would use a screening tool, leading to an almost three‐fold increase in referrals.Public SignificanceAn initiative used to translate screening for an eating disorder to treatment in primary health care had three components. First, provision of an easy referral process to assessment as well as treatment. Second, screening tools were made available on computer desktops. Third, information and training provided to GPs was used to support their clinical observation and increase confidence in initiating screening. Adoption of this initiative almost tripled referrals for assessment.