bluuebunny/crossref_metadata_2025_split huggingface dataset:
History-dependent phase transition character
Authors: Polanšek Juš , Holbl Arbresha , Starzonek Szymon , Drozd-Rzoska Aleksandra , Rzoska Sylwester J. , Kralj Samo 
Published: August 2022

Abstract
We consider history-dependent behavior in domain-type configurations in orientational order that are formed in configurations reached via continuous symmetry-breaking phase transitions. In equilibrium, these systems exhibit in absence of impurities a spatially homogeneous order. We focus on cases where domains are formed via (i) Kibble-Zurek mechanism in fast enough quenches or by (ii) Kibble mechanism in strongly supercooled phases. In both cases, domains could be arrested due to pinned topological defects that are formed at domain walls. In systems exhibiting polar or quadrupolar order, point and line defects (disclinations) dominate, respectively. In particular, the disclinations could form complex entangled structures and are more efficient in stabilizing domains. Domain patterns formed by fast quenches could be arrested by impurities imposing a strong enough random-field type disorder, as suggested by the Imry-Ma theorem. On the other hand, domains formed in supercooled systems could be also formed if large enough energy barriers arresting domains are established due to large enough systems’ stiffness. The resulting effective interactions in established domain-type patterns could be described by random matrices. The resulting eigenvectors reveal expected structural excitations formed in such structures. The most important role is commonly played by the random matrix largest eigenvector. Qualitatively different behavior is expected if this eigenvector exhibits a localized or extended character. In the former case, one expects a gradual, non-critical-type transition into a glass-type structure. However, in the latter case, a critical-like phase behavior could be observed.

Graphical abstract
Synthesis and Characterization of PVA–Fe2O3–CuO Hybrid Structure for Biomedical Application
Authors: Hammood Shahad Ali , Abodood Anwar Ahmed Fadhl , AlGalal Hasan Mohammed Ali Abdullah , Khamees Entidhar Jasim , Abbas Mustafa Fouad , Zabibah Rahman S. , Mohammed Kahtan A. , Ameen Noha Inam 
Published: August 2022

The structural, morphology, and optical properties of a new hybrid structure prepared from CuO nanoparticles embedded in a Fe2O3–PVA composite matrix were investigated in this work. Field emission scanning electron microscopy (FESEM), X-ray diffraction (XRD), absorption and transmission spectra, and Fourier transform infrared spectroscopy (FT-IR) were all used to analyze the prepared materials. Crystallography information revealed the presence of CuO that did not affect the crystal structure of PVA–Fe2O3. The prepared composites revealed strong absorption in the range of 440–570 nm. It was observed that the highest absorption of these composites gradually shifted to the shorter wavelength region with the presence of CuO. PVA–Fe2O3 is highly transparent, with a transmittance of around 85% in the range of 600–800 nm. After the addition of 5% by weight of CuO nanoparticles, the transmittance of the nanocomposite drops to 75% in the same range of wavelength. The prepared materials were used as anti-cancer cells, and they showed high efficacy to kill tumor cells, especially PVA–Fe2O3–CuO at concentration 0.5 [Formula: see text]g/mL.
Angiojet System Used in the Treatment of Submassive Pulmonary Embolism: A Case Report of Two Patients
Authors: Liu Jinbo , Li Tianrun , Huang Wei , Zhao Na , Zhao Hongwei , Wang Hongyu 
Published: August 2022

Background. Massive or submassive pulmonary embolism (PE) carries a high mortality. Percutaneous mechanical thrombectomy using the Angiojet system is accepted for the treatment of PE. Here, we reported two submassive PE cases who were treated with the Angiojet system successfully, to provide some advice for the therapy of submassive PE. Method. Two patients with suffocation were admitted to our hospital. One patient was accompanied by lower blood pressure (20% lower than basal blood pressure) and higher pulmonary artery pressure (89 mmHg); the other patient had larger right ventricular transverse diameter (46 mm), decreased left ventricular end diastolic anteroposterior diameter (34 mm), and higher heartbeats (107 heartbeats per minute). Pulmonary artery computed tomography angiography showed bilateral pulmonary embolism. Result. The Angiojet system with a high-pressure jet spray pattern (urokinase

25

wiu
+
sodium

chloride injection 50 ml) was used. Intravascular thrombolysis by urokinase (100 wiu/day for 1 day) was done after being back in the ward. And low molecular weight heparin was used in hospitalization, and rivaroxaban was used after discharge. Both patients were treated successfully. However, the level of platelet was significantly lower in one patient after Angiojet system usage and recovered to the preoperative level the next day. Another patient suffered from bradyarrhythmias during the usage of Angiojet, and bradyarrhythmias disappeared when the Angiojet system stopped. Pulmonary embolism was cured after 3 months in both patients. Conclusion. Angiojet could be a simple, safe, and well-tolerated treatment for massive or submassive PE. And hematocrit, platelet, kidney function, and heart rhythm should be monitored during perioperation.
Functional Characterization of lncRNA152 as an Angiogenesis-Inhibiting Tumor Suppressor in Triple-Negative Breast Cancers
Authors: Kim Dae-Seok , Camacho Cristel V. , Setlem Rohit , Kim Kangsan , Malladi Srinivas , Hou Tim Y. , Nandu Tulip , Gadad Shrikanth S. , Kraus W. Lee 
Published: August 2022

Abstract

Long noncoding RNAs have been implicated in many of the hallmarks of cancer. Herein, we found that the expression of lncRNA152 (lnc152; a.k.a. DRAIC), which we annotated previously, is highly upregulated in luminal breast cancer (LBC) and downregulated in triple-negative breast cancer (TNBC). Knockdown of lnc152 promotes cell migration and invasion in LBC cell lines. In contrast, ectopic expression of lnc152 inhibits growth, migration, invasion, and angiogenesis in TNBC cell lines. In mice, lnc152 inhibited the growth of TNBC cell xenografts, as well as metastasis of TNBC cells in an intracardiac injection model. Transcriptome analysis of the xenografts indicated that lnc152 downregulates genes controlling angiogenesis. Using pull down assays followed by LC/MS-MS, we identified RBM47, a known tumor suppressor in breast cancer, as a lnc152-interacting protein. The effects of lnc152 in TNBC cells are mediated, in part, by regulating the expression of RBM47. Collectively, our results demonstrate that lnc152 is an angiogenesis-inhibiting tumor suppressor that attenuates the aggressive cancer-related phenotypes found in TNBC.

Implications:
This study identifies lncRNA152 as an angiogenesis-inhibiting tumor suppressor that attenuates the aggressive cancer-related phenotypes found in TNBC by upregulating the expression of the tumor suppressor RBM47. As such, lncRNA152 may serve as a biomarker to track aggressiveness of breast cancer, as well as therapeutic target for treating TNBC.
Science-Driven Nutritional Interventions for the Prevention and Treatment of Cancer
Authors: Montégut Léa , de Cabo Rafael , Zitvogel Laurence , Kroemer Guido 
Published: August 2022

AbstractIn population studies, dietary patterns clearly influence the development, progression, and therapeutic response of cancers. Nonetheless, interventional dietary trials have had relatively little impact on the prevention and treatment of malignant disease. Standardization of nutritional interventions combined with high-level mode-of-action studies holds the promise of identifying specific entities and pathways endowed with antineoplastic properties. Here, we critically review the effects of caloric restriction and more specific interventions on macro- and micronutrients in preclinical models as well as in clinical studies. We place special emphasis on the prospect of using defined nutrition-relevant molecules to enhance the efficacy of established anticancer treatments.Significance:The avoidance of intrinsically hypercaloric and toxic diets contributes to the prevention and cure of cancer. In addition, specific diet-induced molecules such as ketone bodies and micronutrients, including specific vitamins, have drug-like effects that are clearly demonstrable in preclinical models, mostly in the context of immunotherapies. Multiple trials are underway to determine the clinical utility of such molecules.
Ohrmazd’s Divine Mercy and the End of the World between Apocatastasis and Apocalypse
Authors: Panaino Antonio Clemente 
Published: August 2022

Abstract
This article focuses on the central importance of the concept of apocatastasis (or apokatastasis)—the full regeneration of the world and the annihilation of hell—within the framework of the Zoroastrian doctrine of the end of the world, as well as its origin and development. This study insists strongly on a necessary distinction between this idea and the more frequently-encountered doctrine of apocalypse, which does not strictly concern the end of the millennial Mazdæan cycle, but marks only an historical phase of crisis. The idea of apocatastasis does not belong to the earliest Iranian tradition, but was the product of a slow process of adaptation of new theological ideas, partly of Christian origin, that emerged during a period of social crisis. The final synthesis represented a transformation of the theological and philosophical perception of the annihilation of hell in a new universally-optimistic cosmological perspective.
Diversification in ancient Lake Biwa: integrative taxonomy reveals overlooked species diversity of the Japanese freshwater snail genus Semisulcospira (Mollusca: Semisulcospiridae)
Authors: Sawada Naoto , Fuke Yusuke 
Published: August 2022

Abstract
The freshwater snail genus Semisulcospira has adaptively radiated in the ancient Lake Biwa, Japan. Although significant geographical variations have been known in the shell morphology of Semisulcospira niponica, their systematics remain uncertain. We evaluated the systematic status of the geographical variations in S. niponica and its congenerics S. biwae and S. fuscata through morphological and genetic investigations. Genome-wide snp s were used to estimate their genetic relationships. Random Forest algorithms explored the morphological variation of the shells of the name-bearing types and newly collected specimens. Our results detected five genetic clusters and revealed the consistency of adult shell morphology with genetic relationships, reinforcing the robustness of shell morphology-based species delimitation of the genus. The present systematics synonymized S. biwae under S. niponica. The five genetic clusters corresponded to the two described species, S. niponica and S. fuscata, and three new species, Semisulcospira watanabei sp. nov., Semisulcospira nakanoi sp. nov., and Semisulcospira salebrosa sp. nov. discovered among the geographical variations of S. niponica. The observed similarities in substrate preference and differences in distribution patterns among species suggest that the diversification of the genus was accelerated by geographical isolation after the initial ecological niche differentiation. We suggest that the distributions of Semisulcospira species may have been influenced by competitive exclusion among them, and that multiple speciation events have occurred in similar patterns.
Landed Estates, Rural Commons and Collective Agriculture in Ottoman Niş and Leskofçe in the Nineteenth Century
Authors: Terzibaşoğlu Yücel 
Published: August 2022

Abstract
In contesting claims of private ownership of landed estates in mid-nineteenth-century Niş and Leskofçe, peasants argued that they cultivated and possessed the land ‘jointly and commonly’. It was a claim that questioned existing property relations, based on tenancy and sharecropping in landed estates (çiftliks) owned by urban landholders. This article attempts to reconstruct the social organisation of production in the estates by exploring forms of land use and labour which were embedded in forms of collective peasant organisation and practice. It is argued that the co-existence of multiple land use and labour forms under a dominant framework of estate agriculture generated social tensions with long-term consequences.
Does a Mamluk Sultan Hold Religious Authority? Quranic Exegesis and ḥadīṯ Scholarship in Late Mamluk Courtly maǧālis
Authors: Mauder Christian 
Published: August 2022

Abstract
The article critically reexamines the notion of Mamluk rulers being uninterested in religious affairs and the authority a supreme religious status could bestow. It shows that, with the late Mamluk ruler Qāniṣawh al-Ġawrī (r. 906/1501–922/1516), at least one Mamluk sultan laid claim to religious authority through his participation in courtly processes of knowledge production and transmission in his learned maǧālis. These efforts culminated in the attempt to portray al-Ġawrī as “the sultan of scholars and verifiers (sulṭān al-ʿulamāʾ wa-l-muḥaqqiqīn)” and “the sultan of the truly insightful (sulṭān al-ʿārifīn).” Al-Ġawrī used the scholarly status conveyed through these titles to re-affirm a decidedly Sunni interpretation of prophetic traditions and the Quran, thus setting himself apart from many of the so-called “millennial sovereigns” of his time whose claims for spiritual leadership often marked a break with traditional Sunni concepts of political rule and religious authority.
Towards Useful Decadal Climate Services
Authors: Dunstone Nick , Lockwood Julia , Solaraju-Murali Balakrishnan , Reinhardt Katja , Tsartsali Eirini E. , Athanasiadis Panos J. , Bellucci Alessio , Brookshaw Anca , Caron Louis-Philippe , Doblas-Reyes Francisco J. , Früh Barbara , González-Reviriego Nube , Gualdi Silvio , Hermanson Leon , Materia Stefano , Nicodemou Andria , Nicolì Dario , Pankatz Klaus , Paxian Andreas , Scaife Adam , Smith Doug , Thornton Hazel E. 
Published: August 2022

Abstract
The decadal time scale (∼1–10 years) bridges the gap between seasonal predictions and longer-term climate projections. It is a key planning time scale for users in many sectors as they seek to adapt to our rapidly changing climate. While significant advances in using initialized climate models to make skillful decadal predictions have been made in the last decades, including coordinated international experiments and multimodel forecast exchanges, few user-focused decadal climate services have been developed. Here we highlight the potential of decadal climate services using four case studies from a project led by four institutions that produce real-time decadal climate predictions. Working in co-development with users in agriculture, energy, infrastructure, and insurance sectors, four prototype climate service products were developed. This study describes the challenge of trying to match user needs with the current scientific capability. For example, the use of large ensembles (achieved via a multisystem approach) and skillfully predicted large-scale environmental conditions, are found to improve regional predictions, particularly in midlatitudes. For each climate service, a two-page “product sheet” template was developed that provides users with both a concise probabilistic forecast and information on retrospective performance. We describe the development cycle, where valuable feedback was obtained from a “showcase event” where a wider group of sector users were engaged. We conclude that for society to take full and rapid advantage of useful decadal climate services, easier and more timely access to decadal climate prediction data are required, along with building wider community expertise in their use.
Radiologically Guided Versus Blinded Intra-articular Injection in Patients With Hip Osteoarthritis: A Retrospective Comparative Study
Authors: Aksoy Ahmet , Gulcu Anil , Tuna Mehmet Mert , Aslan Ahmet 
Published: August 2022

Objectives: The aim of this study was to present the clinical results of patients with Kellgren-Lawrence (KL) stage 2-4 hip osteoarthritis who were administered intra-articular corticosteroid (CS) or hyaluronic acid (HA), with or without fluoroscopy. Methods: This retrospective comparative study was conducted in the clinics where the authors worked between 2010 and 2018. Patients with stage 2-4 hip osteoarthritis according to KL criteria were included in the study. Age, body mass index, American Society of Anesthesiologists stages, and Western Ontario and McMaster Universities Arthritis Index (WOMAC) scores (3rd, 6th, and 12th months) were recorded. Two groups were created as patients who underwent injection with or without fluoroscopy guidance. In group 1, CS (triamnisolone) was administered, and in group 2, sodium hyaluronate 88 mg/4 mL was administered. Obtained parameters were compared. Results: The WOMAC scores at 3 months of both the CS and HA groups were statistically significantly better than before the application, with the improvement in the CS group found to be significantly better than in the HA group ( P = .047). At 6 months, the mean WOMAC scores of the CS and HA groups were better than prior to the application, and there was a statistically significant difference ( P < .001). No significant difference was found in either the CS or HA group in the comparison of 12-month WOMAC scores with the baseline scores ( P = .744 and P = .054). Conclusion: In symptomatic hip OA patients, intra-articular administration of CS and HA was seen to be effective at 3 and 6 months after administration. However, the effectiveness was determined to have disappeared within 1 year. Furthermore, in hip OA intra-articular drug applications, it was determined that the blinded technique without radiological guidance performed in the outpatient clinic is as effective and safe as the radiologically guided technique administered in the operating room.
Combined Effects of Tanshinone IIA and an Autophagy Inhibitor on the Apoptosis of Leukemia Cells via p53, Apoptosis-Related Proteins and Oxidative Stress Pathways
Authors: Song Ying-Chyi , Kuo Cheng-Chieh , Liu Chuan-Teng , Wu Tsai-Chen , Kuo Yi-Ting , Yen Hung-Rong 
Published: August 2022

Background: Acute myeloid leukemia (AML) is a kind of hematopoietic malignancy with limited response and acquired resistance to therapy. Inducing apoptosis and inhibiting autophagy in tumor cells is a combinational strategy for the development of anticancer therapeutics. Tanshinone IIA (TAIIA) is one of the major ingredients in Salvia miltiorrhiza, which is the most prescribed herb for the treatment of AML in Taiwan. Therefore, this study aimed to delineate the anticancer effects of TAIIA and its effect when combined with an autophagy inhibitor to treat AML. Methods: The anticancer effects of a combination of TAIIA and the autophagy inhibitor 3-methladenine (3MA) on the human monocytic leukemia cell line THP-1 were explored. The apoptosis and cell cycle of the leukemia cells were examined by Annexin V and propidium iodide staining and analyzed by flow cytometry. The oxidative stress level was determined by a malondialdehyde (MDA) colorimetric assay, nitric oxide colorimetric assay and glutathione peroxidase (GPx) colorimetric assay. The expression of apoptosis-related proteins was determined by western blotting. Results: TAIIA treatment significantly induced apoptosis via increased p53, Bax/Bcl, PARP, and caspase-3 signals and oxidative stress by enhancing MDA and nitrate/nitrite production and reducing GPx activity in THP-1 cells in a dose-dependent and time-dependent manner. The combination of the autophagy inhibitor 3MA enhanced TAIIA-induced apoptosis via the p53, Bax/Bcl, PARP, caspase-3, and oxidative stress pathways in THP-1 cells. Conclusion: The results suggest that TAIIA and autophagy inhibitors have combined effects on the apoptosis of leukemia cells, thus representing a novel and effective combination with the potential for application as a clinical therapy for AML.
Housing With Care for Older People: A Scoping Review Using the CASP Assessment Tool to Inform Optimal Design
Authors: Jung Suyee , Uttley Lesley , Huang Junjie 
Published: August 2022

Objective: The purpose of this scoping review is to synthesize and map available evidence on the design of “housing with care” (HWC) schemes to inform design decisions built on objective data from previous research, which is key to ensuring such schemes are fit for purpose for older people. Background: HWC is becoming increasingly recognized as a model for developing housing schemes for older people and balances independent living with elevated levels of care. However, as this scheme is still relatively novel, there are currently no established theoretical frameworks to inform design. Methods: Scoping review, thematic analysis, and mapping methods were used to comprehensively search for and synthesize evidence that links design with assessments of quality-of-life data for HWC schemes. Study findings for each included paper were subject to data extraction for inductive analysis, and the quality of each study was assessed using a modified critical appaisal skills programme (CASP) checklist. Results: Our searches yielded 821 unique references, of which 18 unique articles met the inclusion criteria. The outcomes of interest were the design considerations or features in HWC schemes and their impact on the residents. The main themes identified were related to design element, accessibility, maneuverability, views, design procedure, and quality of life (QOL). Further subthemes identified across papers were identified to create a comprehensive map of the key features to consider in designing HWC schemes. Conclusion: This review provides an initial framework for designers and architects to (1) understand the effect of each design element of HWC and (2) inform design to ultimately improve the QOL of aged people.
Therapeutic Exercises and Modalities in Athletes With Acute Hamstring Injuries: A Systematic Review and Meta-analysis
Authors: Jankaew Amornthep , Chen Jih-Ching , Chamnongkich Samatchai , Lin Cheng-Feng 
Published: August 2022

Context: Hamstring strain is a common injury to the lower limbs. Early intervention in the acute phase aids with restoring hamstring function and prevents secondary related injury. Objective: To systematically review and summarize the effectiveness of exercise-based interventions combined with physical modalities currently used in athletes with acute hamstring injuries. Data Sources: Five databases (EMBASE, Medline, Cochrane Library, SPORTDiscus, and Web of Science) were searched from inception to July 2021. Study Selection: A total of 4569 studies were screened. Nine randomized controlled trials (RCTs) on the effect of therapeutic exercise programs with and without physical agents in athletes with acute hamstring injuries were identified for meta-analysis. Study Design: Systematic review and meta-analysis. Level of Evidence: Level 1. Data Extraction: The studies were screened, and the evidence was rated using the PEDro scale. Nine RCTs with PEDro scores ranging between 3 and 9 were included and extracted pain intensity, time to return to play (TTRTP), and reinjury rate in the study. Results: Loading exercises during extensive lengthening were shown to facilitate TTRTP at P < 0.0001 but did not prevent recurrence ( P = 0.17), whereas strengthening with trunk stabilization and agility exercise did not reduce the duration of injury recurrence ( P = 0.16), but significantly reduced the reinjury rate ( P < 0.007) at a 12-month follow-up. The results of the stretching programs and solely physical modalities could not be pooled in the statistical analysis. Conclusion: The meta-analysis indicated that a loading program helps athletes to return to sports on a timely basis. Although strengthening with trunk stabilization and agility exercise cannot significantly reduce recovery time, the program can prevent reinjury. The clinical effects of stretching programs and pure physical modality interventions could not be concluded in this study due to limited evidence. PROSPERO Registration: CRD42020183035.