bluuebunny/crossref_metadata_2025_split huggingface dataset:
Research progress of Nedd4L in cardiovascular diseases
Authors: Li Mohan , Sun Guozhe , Wang Pengbo , Wang Wenbin , Cao Kexin , Song Chunyu , Sun Yingxian , Zhang Ying , Zhang Naijin 
Published: April 2022

Abstract
Post-translational modifications (PTMs) are a covalent processing process of proteins after translation. Proteins are capable of playing their roles only after being modified, so as to maintain the normal physiological function of cells. As a key modification of protein post-translational modification, ubiquitination is an essential element, which forms an enzyme-linked reaction through ubiquitin-activating enzyme, ubiquitin binding enzyme, and ubiquitin ligase, aiming to regulate the expression level and function of cellular proteins. Nedd4 family is the largest group of ubiquitin ligases, including 9 members, such as Nedd4-1, Nedd4L (Nedd4-2), WWP1, WWP2, ITCH, etc. They could bind to substrate proteins through their WW domain and play a dominant role in the ubiquitination process, and then participate in various pathophysiological processes of cardiovascular diseases (such as hypertension, myocardial hypertrophy, heart failure, etc.). At present, the role of Nedd4L in the cardiovascular field is not fully understood. This review aims to summarize the progress and mechanism of Nedd4L in cardiovascular diseases, and provide potential perspective for the clinical treatment or prevention of related cardiovascular diseases by targeting Nedd4L.
Roles of resonant muonic molecule in new kinetics model and muon catalyzed fusion in compressed gas
Authors: Yamashita Takuma , Kino Yasushi , Okutsu Kenichi , Okada Shinji , Sato Motoyasu 
Published: April 2022

AbstractMuon catalyzed fusion ($$\mu$$
μ
CF) in which an elementary particle, muon, facilitates the nuclear fusion between the hydrogen isotopes has been investigated in a long history. In contrast to the rich theoretical and experimental information on the $$\mu$$
μ
CF in cold targets, there is relatively scarce information on the high temperature gas targets of deuterium-tritium mixture with high-thermal efficiency. We demonstrate new kinetics model of $$\mu$$
μ
CF including three roles of resonant muonic molecules, (i) changing isotopic population, (ii) producing epi-thermal muonic atoms, and (iii) inducing fusion in-flight. The new kinetics model reproduces experimental observations, showing higher cycle rate as the temperature increasing, over a wide range of target temperatures ($$T<800$$

T
<
800

K) and tritium concentrations. Moreover, it can be tested by measurements of radiative dissociation X-rays around 2 keV. High energy-resolution X-ray detectors and intense muon beam which are recently available are suitable to reveal these dynamical mechanism of $$\mu$$
μ
CF cycles. Towards the future $$\mu$$
μ
CF experiments in the high-temperature gas target we have clarified the relationship between the fusion yield and density-temperature curve of adiabatic/shock-wave compression.
How bilingualism modulates selective attention in children
Authors: Phelps Jacqueline , Attaheri Adam , Bozic Mirjana 
Published: April 2022

AbstractThere is substantial evidence that learning and using multiple languages modulates selective attention in children. The current study investigated the mechanisms that drive this modification. Specifically, we asked whether the need for constant management of competing languages in bilinguals increases attentional capacity, or draws on the available resources such that they need to be economised to support optimal task performance. Monolingual and bilingual children aged 7–12 attended to a narrative presented in one ear, while ignoring different types of interference in the other ear. We used EEG to capture the neural encoding of attended and unattended speech envelopes, and assess how well they can be reconstructed from the responses of the neuronal populations that encode them. Despite equivalent behavioral performance, monolingual and bilingual children encoded attended speech differently, with the pattern of encoding across conditions in bilinguals suggesting a redistribution of the available attentional capacity, rather than its enhancement.
High-throughput precise particle transport at single-particle resolution in a three-dimensional magnetic field for highly sensitive bio-detection
Authors: Abedini-Nassab Roozbeh , Shourabi Reza 
Published: April 2022

AbstractPrecise manipulation of microparticles have fundamental applications in the fields of lab-on-a-chip and biomedical engineering. Here, for the first time, we propose a fully operational microfluidic chip equipped with thin magnetic films composed of straight tracks and bends which precisely transports numerous single-particles in the size range of ~ 2.8–20 µm simultaneously, to certain points, synced with the general external three-axial magnetic field. The uniqueness of this design arises from the introduced vertical bias field that provides a repulsion force between the particles and prevents unwanted particle cluster formation, which is a challenge in devices operating in two-dimensional fields. Furthermore, the chip operates as an accurate sensor and detects low levels of proteins and DNA fragments, being captured by the ligand-functionalized magnetic beads, while lowering the background noise by excluding the unwanted bead pairs seen in the previous works. The image-processing detection method in this work allows detection at the single-pair resolution, increasing the sensitivity. The proposed device offers high-throughput particle transport and ultra-sensitive bio-detection in a highly parallel manner at single-particle resolution. It can also operate as a robust single-cell analysis platform for manipulating magnetized single-cells and assembling them in large arrays, with important applications in biology.
Collisional positron acoustic soliton and double layer in an unmagnetized plasma having multi-species
Authors: Akter Shahrina , Hafez M. G. 
Published: April 2022

AbstractThis paper explores the head-on collision between two-counter propagating positron acoustic solitons and double layers (DLs) in an unmagnetized collisionless plasma having mobile cold positrons fluid, immobile positive ions and ($$r,\;q$$

r
,

q

)-distributed hot positrons, and hot electrons. By employing the extended Poincaré–Lighthill–Kuo method, the coupled Korteweg–de Vries (KdV), modified KdV (mKdV) and Gardner equations are derived to archive this goal. The effect of dimensionless parameters on the propagation characteristics of interacting KdV solitons (KdVSs), mKdV solitons (mKdVSs), Gardner solitons (GSs) and DLs are examined in detail by considering the limiting cases of ($$r,\;q$$

r
,

q

)-distribution. It is noted that the interaction of GSs and DLs are reported for the first time. The outcomes might be comprehended and beneficial not only in space and astrophysical environments but also in laboratory studies.
Observational study of rebiopsy in EGFR-TKI-resistant patients with EGFR mutation-positive advanced NSCLC
Authors: Koyama Kenichi , Miura Satoru , Watanabe Satoshi , Shoji Satoshi , Koshio Jun , Hayashi Yoshiki , Ishikawa Daisuke , Sato Ko , Miyabayashi Takao , Okajima Masaaki , Ota Takeshi , Tanaka Tomohiro , Matsumoto Naoya , Kuriyama Hideyuki , Abe Tetsuya , Nozaki Koichiro , Ichikawa Kosuke , Kondo Rie , Tanaka Hiroshi , Kikuchi Toshiaki 
Published: April 2022

AbstractThe identification of acquired resistance mutations has been essential in non-small-cell lung cancer (NSCLC) patients with epidermal growth factor receptor (EGFR) active mutations. Rebiopsy plays a pivotal role in selecting the optimal treatment for patients who develop resistance to initial EGFR-tyrosine kinase inhibitors (EGFR-TKIs). This multicenter, observational study was conducted to investigate the details of rebiopsy in Japanese clinical practice. The primary endpoints were the implementation rate of rebiopsy and the concordance rate for T790M mutation detection between histological and cytological specimens using the cobas EGFR Mutation Test, version 2. One hundred ninety-four patients with EGFR-mutant NSCLC were enrolled, and 120 patients developed acquired resistance to EGFR-TKIs. The median age was 68 years (range 20–87), and 52.5% of the patients were women. Rebiopsy was performed in 109 patients, and the implementation rate of rebiopsy was 90.8%. The success rates of rebiopsy in the total, histology, cytology and liquid biopsy populations were 67.9%, 81.3%, 66.7% and 43.8%, respectively. The positive percent agreement and the negative percent agreement in the detection of the T790M mutation between the histological and cytological specimens were both 90.9%. Obtaining histological or cytological tissue samples at rebiopsy may contribute to improving the detection rate of the T790M mutation (trial registration number: UMIN000026019).
Accuracy and self-validation of automated bone age determination
Authors: Martin D. D. , Calder A. D. , Ranke M. B. , Binder G. , Thodberg H. H. 
Published: April 2022

AbstractThe BoneXpert method for automated determination of bone age from hand X-rays was introduced in 2009 and is currently running in over 200 hospitals. The aim of this work is to present version 3 of the method and validate its accuracy and self-validation mechanism that automatically rejects an image if it is at risk of being analysed incorrectly. The training set included 14,036 images from the 2017 Radiological Society of North America (RSNA) Bone Age Challenge, 1642 images of normal Dutch and Californian children, and 8250 images from Tübingen from patients with Short Stature, Congenital Adrenal Hyperplasia and Precocious Puberty. The study resulted in a cross-validated root mean square (RMS) error in the Tübingen images of 0.62 y, compared to 0.72 y in the previous version. The RMS error on the RSNA test set of 200 images was 0.45 y relative to the average of six manual ratings. The self-validation mechanism rejected 0.4% of the RSNA images. 121 outliers among the self-validated images of the Tübingen study were rerated, resulting in 6 cases where BoneXpert deviated more than 1.5 years from the average of the three re-ratings, compared to 72 such cases for the original manual ratings. The accuracy of BoneXpert is clearly better than the accuracy of a single manual rating. The self-validation mechanism rejected very few images, typically with abnormal anatomy, and among the accepted images, there were 12 times fewer severe bone age errors than in manual ratings, suggesting that BoneXpert could be safer than manual rating.
Investigating the dispersal of macro- and microplastics on agricultural fields 30 years after sewage sludge application
Authors: Weber Collin J. , Santowski Alexander , Chifflard Peter 
Published: April 2022

AbstractPlastic contamination of terrestrial ecosystems and arable soils pose potentially negative impacts on several soil functions. Whereas substantial plastic contamination is now traceable in agro-landscapes, often internal-caused by the application of fertilizers such as sewage sludge, questions remain unanswered concerning what happens to the plastic after incorporation. Based on a combined surface and depth sampling approach, including density separation, fluorescence staining and ATR-FTIR or µFTIR analyses, we quantified macro- and microplastic abundance on two agricultural fields—34 years after the last sewage sludge application. By sub-dividing the study area around sludge application sites, we were able to determine spatial distribution and spreading of plastics. Past sewage sludge application led to a still high density of macroplastics (637.12 items per hectare) on agricultural soil surfaces. Microplastic concentration, measured down to 90 cm depth, ranged from 0.00 to 56.18 particles per kg of dry soil weight. Maximum microplastic concentrations were found in regularly ploughed topsoils. After 34 years without sewage sludge application, macro- and microplastic loads were significantly higher on former application areas, compared to surrounding areas without history of direct sewage application. We found that anthropogenic ploughing was mainly responsible for plastic spread, as opposed to natural transport processes like erosion. Furthermore, small-scale lateral to vertical heterogeneous distribution of macro- and microplastics highlights the need to determine appropriate sampling strategies and the modelling of macro- and microplastic transport in soils.
Deep learning-based single image super-resolution for low-field MR brain images
Authors: de Leeuw den Bouter M. L. , Ippolito G. , O’Reilly T. P. A. , Remis R. F. , van Gijzen M. B. , Webb A. G. 
Published: April 2022

AbstractLow-field MRI scanners are significantly less expensive than their high-field counterparts, which gives them the potential to make MRI technology more accessible all around the world. In general, images acquired using low-field MRI scanners tend to be of a relatively low resolution, as signal-to-noise ratios are lower. The aim of this work is to improve the resolution of these images. To this end, we present a deep learning-based approach to transform low-resolution low-field MR images into high-resolution ones. A convolutional neural network was trained to carry out single image super-resolution reconstruction using pairs of noisy low-resolution images and their noise-free high-resolution counterparts, which were obtained from the publicly available NYU fastMRI database. This network was subsequently applied to noisy images acquired using a low-field MRI scanner. The trained convolutional network yielded sharp super-resolution images in which most of the high-frequency components were recovered. In conclusion, we showed that a deep learning-based approach has great potential when it comes to increasing the resolution of low-field MR images.
Transcriptional profiling of macrophages reveals distinct parasite stage-driven signatures during early infection by Leishmania donovani
Authors: Chaparro Visnu , Graber Tyson E. , Alain Tommy , Jaramillo Maritza 
Published: April 2022

AbstractMacrophages undergo swift changes in mRNA abundance upon pathogen invasion. Herein we describe early remodelling of the macrophage transcriptome during infection by amastigotes or promastigotes of Leishmania donovani. Approximately 10–16% of host mRNAs were differentially modulated in L. donovani-infected macrophages when compared to uninfected controls. This response was partially stage-specific as a third of changes in mRNA abundance were either exclusively driven by one of the parasite forms or significantly different between them. Gene ontology analyses identified categories associated with immune functions (e.g. antigen presentation and leukocyte activation) among significantly downregulated mRNAs during amastigote infection while cytoprotective-related categories (e.g. DNA repair and apoptosis inhibition) were enriched in upregulated transcripts. Interestingly a combination of upregulated (e.g. cellular response to IFNβ) and repressed (e.g. leukocyte activation, chemotaxis) immune-related transcripts were overrepresented in the promastigote-infected dataset. In addition, Ingenuity Pathway Analysis (IPA) associated specific mRNA subsets with a number of upstream transcriptional regulators predicted to be modulated in macrophages infected with L. donovani amastigotes (e.g. STAT1 inhibition) or promastigotes (e.g. NRF2, IRF3, and IRF7 activation). Overall, our results indicate that early parasite stage-driven transcriptional remodelling in macrophages contributes to orchestrate both protective and deleterious host cell responses during L. donovani infection.
Vaccine hunters and jostlers may have hurt the COVID-19 vaccination effort
Authors: Mollerstrom Johanna , Thunström Linda 
Published: April 2022

AbstractWe examine how salience of extreme actions to gain access to vaccines affect general vaccine preferences using a survey experiment conducted shortly after a limited supply of COVID-19 vaccines were made available to prioritized groups. We document that learning about people who jump the line (jostlers) or people who go through great lengths to secure left-over vaccine doses (hunters) is off-putting, and has a meaningful, negative effect on people’s vaccine preferences. Most people, however, predict the opposite—that news about extreme behavior would help the vaccination effort. If policy makers or public health authorities share these incorrect beliefs, they run the risk of implementing information policies that backfire in their effort to signal desirability of the vaccine.
Pomegranate trees quality under drought conditions using potassium silicate, nanosilver, and selenium spray with valorization of peels as fungicide extracts
Authors: Mosa Walid F. A. , Behiry Said I. , Ali Hayssam M. , Abdelkhalek Ahmed , Sas-Paszt Lidia , Al-Huqail Asma A. , Ali Muhammad Moaaz , Salem Mohamed Z. M. 
Published: April 2022

AbstractThe current study was performed on 8 years old "Succary" pomegranate cultivar (Punica granatumL.) during the 2019 and 2020 seasons. One hundred pomegranate trees were chosen and sprayed three times at the beginning of flowering, full bloom, and 1 month later with the following treatments: water as control, 0.025, 0.05 and 0.1 mg/L Se; 5 mL/L, 7.5 and 10 mL/L Ag NPs, and 0.5, 1 and 2 mg/L K2Si2O5. The results showed that spraying of SE, Ag NPs, and K2Si2O5ameliorated the shoot length, diameter, leaf chlorophyll content, set of fruiting percentage, and fruit yield per tree and hectare compared to control through studying seasons. Moreover, they improved the fruit weight, length, and diameter, as well as total soluble solids, total, reduced, and non-reduced sugars percent, while they lessened the juice acidity percentage compared to control. The most obvious results were noticed with Se at 0.1 mg/L, Ag NPs at 10 mL/L, and K2Si2O5at 2 mg/L in both experimental seasons over the other applied treatments. By HPLC analysis, peel extracts showed the presence of several bioactive compounds of catechol, syringic acid, p-coumaric acid, benzoic acid, caffeic acid, pyrogallol, gallic acid, ferulic acid, salicylic acid, cinnamic acid, and ellagic acid. The extracts applied to Melia azedarach wood showed promising antifungal activity againstRhizoctonia solaniand were considered wood-biofingicides.
Optical reciprocity induced wavefront shaping for axial and lateral shifting of focus through a scattering medium
Authors: Sanjeev Abhijit , Trivedi Vismay , Zalevsky Zeev 
Published: April 2022

AbstractLight propagating along a reversed path experiences the same transmission coefficient as in the forward direction, independent of the path complexity. This is called the optical reciprocity of light, which is valid for not too intense scattering media as well. Hence, by utilizing the reciprocity principle, the proposed novel technique can achieve axially and laterally tunable focus, non-invasively, through a scattering media without a priori knowledge or modeling of its scattering properties. Moreover, the uniqueness of the proposed technique lies in the fact that the illumination and detection are on the same side of the scattering media.
An AHP based approach to forecast groundwater level at potential recharge zones of Uckermark District, Brandenburg, Germany
Authors: Raihan Ahmed Tahmid , Bauer Sonja , Mukhopadhaya Sayan 
Published: April 2022

AbstractUckermark, a district of the state Brandenburg, Germany is situated in one of the driest regions of Germany. The district is known for its agricultural activities and natural resources. But in recent times the district is being prone to groundwater deficit due to the dryness of its climate. In this research initiative, a GIS and Remote Sensing based approach has been made to detect the potential groundwater recharge zones of Uckermark district and observe the groundwater level condition over a period of 21 years (2000–2020). Analytic Hierarchy Process has been used to locate the potential groundwater recharge zones and later a Long Short-Term Memory (LSTM) based model has been developed to forecast the seasonal groundwater level for the upcoming five years in the potential groundwater recharge zones based on observation data from groundwater measurement points. This enabled us to see the groundwater condition of Uckermark in near future and point out the necessary steps to be taken.
Babesiosis in cattle and ixodid tick distribution in Dasenech and Salamago Districts, southern Ethiopia
Authors: Fesseha Haben , Mathewos Mesfin , Eshetu Eyob , Tefera Bereket 
Published: April 2022

AbstractBabesiosis, caused by protozoan parasites of the genus Babesia, and ixodid ticks are considered to be one of the most important causes that result in significant economic losses in cattle production worldwide, including in Ethiopia. A cross-sectional study was undertaken in the Dasenech and Salamago Districts of South Omo zone Ethiopia to determine the prevalence and associated risk factors of babesia infection and ixodid ticks of cattle using Giemsa-stained thin and thick film techniques and morphological identification keys for babesia species and tick identification, respectively. Out of 470 examined cattle, 102 (21.7%) were infected by Babesiosis (15.53% Babesia bigemina and 6.17% Babesia bovis). A statistically significant association (p < 0.05) was observed between babesia infection and season and tick infestation. However, cattle that were infected with the Babesia parasite revealed a lower mean PCV value (21.49%) than noninfected cattle (28.29%) and showed a statistically significant (p < 0.05) difference with the occurrence of Babesia infection. The overall prevalence of ixodid ticks was 53.8% (253/470) and revealed a statistically significant association (p < 0.05) between the season and origin of the animal. However, no statistically significant association (p > 0.05) was observed between sex, age, and body condition score of the animal with the occurrence of ixodid tick. A total of 8040 adult ticks belonging to four tick genera, Amblyomma, Rhipicephalus (Boophilus), Hyalomma, and Rhipicephalus, were collected from various body parts and identified. The high prevalence of Babesia infection and ixodid ticks in cattle at the study sites requires seroprevalence and molecular studies to identify the predominant Babesia species and to detect Babesia in tick hemolymph for the identification of tick genera responsible for the occurrence of Babesia infection. Additionally, tailoring suitable and coordinated tick management methods using chemotherapy as well as strategic treatment to overt clinical cases of bovine babesiosis is critical.