bluuebunny/crossref_metadata_2025_split huggingface dataset:
Excavate the role of E2F family in the prognosis, drug sensitivity analyses, and Immune cell infiltration of KIRC (Kidney Clear Cell Carcinoma)
Authors: He Xing Jun , Li Junhui , Tian Feng , Yin Gui Cao , Tian Hao Yu , Sha Wei , Qi Le Zhong , Li Yi Fan , Wang Xiao Xiang , Pan Xiang 
Published: December 2022

Abstract
KIRC is a common malignant tumor with few early symptoms, usually been found and diagnosed when it becomes large with hematuria, kidney injury and abdominal mass. E2F family include 8 genes (E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, E2F7 and E2F8) and express high in virtually all cancers. Their role in cell proliferation has been extensively studied. Regrettably, there are very few reports about the interrelationship between KIRC and E2Fs. In order to research their relation, by taking great advantage of some reliable datasets and bioinformaticsx tools, we excavated the expression level of E2Fs, the prognostic value of E2Fs in KIRC, co-expression network, drug sensitivity analysis, kinase target and immune cell infiltration of E2Fs in KIRC patient. Our work may provide new insights into the selection of immunotherapeutic targets and prognostic biomarkers for KIRC. It also provides more data to help clinicians select appropriate therapeutic agents and more accurately predict the long-term prognosis of patients with renal cancer. Method: GEPIA, UALCAN, cBioPortal, GeneMANIA, DAVID 6.8, Metascape, TRRUST, TIMER, and LinkedOmics were used in this study.
An efficient constraint programming approach to signal recovery in compressed sensing
Authors: Nouasria Hamid , Et-tolba Mohamed 
Published: December 2022

Abstract
Compressed sensing (CS) allows for the useful information conveyed by a signal to be completely acquired in a few measurements from which the original signal can be accurately reconstructed. This is made possible because of the sparsity property of the original signal, and the existing powerful optimization theory that gave birth to numerous recovery algorithms. With the aim of CS performance improvement, in this paper, we propose the constraint programming (CP) solvers as an alternative to the classical recovery algorithms in the CS process. We show that contrarily to the conventional recovery algorithms, the proposed approach is sensitive to the sensing matrix variance, and provides better performance. Besides, we demonstrate that even non-sparse signals can be recovered with CP-based signal recovery.
Potentials of Cellulose and Silica-based Materials for Enzyme Immobilization
Authors: Wonorahardjo Surjani , Suharti Suharti , Yuniawati Nurakhma , Fatimasari Emada , Setyaningtyas Anis , Haula Hamizah , Susanti Evi , Molo Antonius DRP , Maharani Chariztya A , Sari Dian Puspita 
Published: December 2022

Abstract
This research aims to develop biomaterials for a place for enzyme immobilization in a designed porous matrix. Hydrolyzed bacterial cellulose was entrapped in the silica rice husk surface during gelling to modify the surface properties. Immobilized enzymes were investigated for their life duration and reusability. In this research, cellulase, trypsin, and lipase enzymes were used as probe enzymes to be immobilized in the silica-cellulose matrix, and their activity was tested using spectroscopic techniques. The systems exhibited good reusability up to 6 cycles with the also interesting outcome from the dynamics in the interface, which were varied by temperature, pH, and stirring speed. Silica-cellulose was also compared to silica alone in this experiment. When physical interaction with surfaces was assumed, enzyme activity decreased to 10, 20, and 40% due to confinement but underwent complex dynamics due to speedy adsorption-desorption equilibrium.
Evolution and divergence of the genetic lineage of Rabies Virus Desmodus rotundus/Artibeus lituratus in São Paulo State
Authors: de Souza Débora Nunes , Oliveira Rafael Novaes , Bettoni Fabiana , Asprino Paula Fontes , Macedo Carla Isabel , Achkar Samira Maria , Fahl Willian de Oliveira , Brandão Paulo Eduardo , Castilho Juliana Galera 
Published: December 2022

Abstract
Since 1998, with the occurrence of the last case of rabies in dogs or cats in São Paulo State related to the dog-specific rabies virus (RABV) lineage, 55 cases of rabies in these animals have been reported until 2021, and the vast majority (51) have been genetically characterized as belonging to the Desmodus rotundus/Artibeus lituratus lineage of RABV, However, it has not been demonstrated so far if there is the possibility to infer which of these bats acted as a source of infection in these cases through the genetic sequencing of isolated RABV. In order to characterize the Desmodus rotundus/Artibeus lituratus lineage aiming at the possibility of differentiating its isolates in RABV associated with each of these reservoirs, this research performed the DNA sequencing technique by amplification on the Illumina Miseq platform in 70 RABV isolates from the State of São Paulo, sent to the virology laboratory of the Pasteur Institute of São Paulo between 2006–2015, being 33 related to the hematophagous bat D. rotundus and 37 to the fruit bat A. lituratus. A genomic approach using phylogenetic and nucleotide identity analyses demonstrated that the isolates investigated in this study can be considered as belonging to the same genetic lineage of RABV and that in São Paulo State the D. rotundus/A. lituratus lineage is subdivided into at least four phylogenetic sub lineages, two associated with D. rotundus and two with A. lituratus, and that these results can be practically applied to the epidemiological surveillance of rabies in this state.
Exploring the Quality of Nexus among the College-going Adolescents with their Parents in Bangladesh: A Public Health Perspective
Authors: Chowdhury Farhana Ishrat , Hossain Syed Billal , BakiBillah Abul Hasan , Khan Ayub , Shahjahan Md. , Chowdhury ABM Alauddin 
Published: December 2022

Abstract
This study aims to investigate the relationship between parental bonding and parent-child relationships among college-going adolescents. A scale suggested by Robert C. Pianta (1992) was used in this quantitative, cross-sectional study with a descriptive design. Among 1000 students of Chattogram Biggan College and Chattogram Commerce College in Chattogram, Bangladesh, 101 individuals were selected. The demographic profile of the participants; 46% of the respondents were male and 54% were female, all of them were aged between 17 to 19. Regarding feelings about spending time with parents, it was discovered that 62.4% of the total 101 participants are delighted with their mother, while 49% are very happy with their father. While 5.9% and 3% of participants are unhappy and very unhappy with their mothers, just 3.5% of the total participants are unhappy with their fathers. While a significant proportion (almost 40%) have a strong bond with their mother. On the other hand, over three-quarters of respondents have disagreements with their fathers' proximity and dependence, according to the research. While a sizable proportion (about 30%) have a strong bond with their father. Whereas over 40% of respondents calculated overall intimacy with their father was low, and nearly 30% with their mother, the remaining respondents were either medium or highly intimate with their parents. Overall relationship intimacy with mothers and fathers was also found to be linked to various relationship characteristics such as conflict (P<0.000), closeness (P<0.000), and dependence (P<0.000) according to the findings. Things that participants liked (P-value=0.047) and disliked (P-value=0.040) most about their mother, feelings when spending time with their mother (P-value=0.066), and things that dislike most about their father (P-value=0.058) had a marginally significant connection with gender.
GATA4 regulates mitochondrial biogenesis and functions during cardiac development and rescues cardiac and mitochondrial functions impaired by TKIs
Authors: Liu Qing , Wu Haodi , Duren Zhana , Jiang Chao , Bortle Kevin Van , Zhao Mingtao , Guo Hongchao , Zhu Chenchen , Luo Qing-Jun , Zhao Bingqing , Liu Jun , Marciano David , Gruber Joshua , Lipchik Andrew , Narasimha Anil , Watson Nathaniel , Tsai Ming-Shian , Furihata Takaaki , Tian Lei , Wei Eric , Li Yingxin , Steinmetz Lars , Wong Wing H. , Kay Mark , Wu Joseph , Snyder Michael 
Published: December 2022

AbstractTyrosine kinase inhibitors (TKIs) have been widely used for cancer chemotherapy, but they also cause cardiotoxicities in cancer patients. In this study, we used human stem cells as anin-vitrosystem to interrogate the mechanisms underlying drug-induced toxicity in differentiated cardiomyocytes, including anticancer tyrosine kinase inhibitor (TKI) drugs, including imatinib, sunitinib, and vandetanib. Sublethal TKI exposure produces multiple effects, including disarranged sarcomere structure, interrupted Ca2+-handling, and impaired mitochondrial function, evident of TKI-induced toxicity in differentiated cardiomyocytes. GATA4-mediated regulatory networks, including key mitochondrial target genes, emerge as significant molecular signatures in integrated analyses of transcriptome and chromatin accessibility dynamics. We find that, on a molecular level, GATA4 acts as a regulatory factor in mitochondrial biogenesis and OXPHOS by directly regulating specific metabolism-related genes, such asPPARGC1A. Functional genomic experiments targeting GATA4 reveals that GATA4 upregulation by CRISPR-activation is able to restore mitochondrial morphology and OXPHOS upon TKI exposure. In addition, we also identified that GATA4 is involved in regulation of mitochondrial biogenesis during early cardiac differentiation; inhibition of GATA4 during differentiation reduces mitochondrial DNA content, ATP production, and OXPHOS in differentiated cardiomyocytes, demonstrating a developmental role of GATA4 in metabolic management during early cardiac differentiation. Altogether, our study identifies a novel link between GATA4 and mitochondria in cardiomyocytes, and identifies GATA4 as a promising therapeutic target for reducing TKI-induced cardiotoxicity for human health.
Monkeypox-induced proctitis: a case report of an emerging complication
Authors: Rathore Azeem , Kahn Cameron , Reich Daniel , Qadir Nadim , Verdecia Jorge , House Jeffrey G. 
Published: December 2022

Abstract
At the outset of the 2022 human monkeypox virus outbreak, the World Health Organization described the self-limited disease as a rash illness associated with nonspecific symptoms such as fever, myalgias, and lymphadenopathy. Historically, the infection caused by this zoonotic virus has presented with rashes primarily on the face, palms, and soles of feet. However, emerging case report literature from the 2022 recent outbreak highlighted more atypical presentations ranging from ocular manifestations to myocarditis. We present a case of a 32-year-old African American male with a past medical history of poorly controlled acquired immunodeficiency syndrome and external hemorrhoids that presented for worsening rectal pain. The patient was afflicted with diffuse skin lesions even present on his hemorrhoids. Initial imaging significant circumferential rectal thickening consistent with proctitis. Subsequent polymerase chain reaction testing confirmed active monkeypox infection and a 14-day course of twice daily tecovirimat 600 mg was initiated to treat disseminated monkeypox infection. After improved pain control and starting antiviral treatment, the patient was discharged two days later. As more cases of monkeypox-associated proctitis emerge, clinicians should keep this disease in their differential due to the growing atypical presentations that have diverged from previous patterns to avoid the risk of misdiagnosing another sexually transmitted infection. Additionally, appropriate medical management is still not definitive and requires further development of evidence-based protocols to treat such patients.
Dealing with Wolves and Livestock Protection Measures in the Alps: Perspectives about Farmers and Shepherds Knowledge and Perceptions
Authors: Maria Benciolini , Julia Stauder 
Published: December 2022

Abstract
The current study aims at understanding the reasons behind herd protection measures rejection or approval among shepherds and livestock farmers in selected regions of the Alps. Through semi-structured interviews, the study examines the sources of knowledge and perceptions of target groups toward wolves and livestock protection. Furthermore, the study explores the problems related to the implementation of herd protection measures and to the exercise of the shepherd’s profession. The results clearly show multiple challenges related to livestock protection and farming that go beyond the sole problem of wolf presence. Key results highlight the general distrust of farmers towards official authorities or NGOs and the importance of peer-to-peer information for experience-based knowledge creation. Additionally, the potential social pressure within groups, and the need to support farmers and shepherds willing to adapt protection measures on a larger scale must be considered in future management actions.
Mechanism Based Designing, Synthesis and Evaluation of Nitrogen and Non-nitrogen Derivatives of Biphosphonates as Anti-inflammatory Agents
Authors: Nagar Akhil , Bardiya Ruchita , Shirkhedkar Atul , Patil Kalpesh R , Soni Viren , Modi Arjun , Shah Khushbu , Patel Roshani 
Published: December 2022

Abstract
The inflammatory mechanisms are complex due to the involvement of multiple pathways. The messengers like PIP2 and IP3 are phosphonate containing biomolecules which are desirable for the delivery of biological responses. In the present study, we designed a novel series of nitrogen and non-nitrogen containing bisphosphonates fused with more lipophilic chalcone moiety. We assume to maintain the hydrophilic ratio of BPs with hydrophobic chalcone substitution. The synthesized compounds 1–11, demonstrated potential anti-inflammatory activity against carrageenan-induced rat paw edema model and in-vitro COX-2 assay. The modifications over the synthesized derivatives were supported by in silico studies and SAR of bisphosphonates. In vitro study was carried out at concentration of 1µM while in vivo study was performed using the carrageenan-induced rat paw edema model. From the study it was concluded that the binding pattern of synthesized derivatives was remarkably similar to the co-crystallized ligand, and also the anti-inflammatory effect of compound was based on the interactions between bisphosphonates and amino acids. The distance between the P-C-P linkage of bisphosphonates to nitrogen and free carbon attached to nitrogen were found to be important for the maximum interaction and biological response considering the co-crystalized ligand in another enzyme. An assessment of cyclooxygenase inhibitory activity (in vitro) of compounds (1, 9, and 11) revealed a structure activity relationship while in vivo inhibitory action of compound 9, 11, 1, 10, and 3 is indicative of its inhibitory action on the prostaglandin synthesis which may be mediated through the inhibition of COX-2 enzyme.
Convergent Encryption Enabled Secure Data Deduplication Algorithm for Cloud Environment
Authors: Ahmad Shahnawaz , Mehfuz Shabana , Shakeel Iman 
Published: December 2022

Abstract
The exponential growth of data management nowadays is quite a tedious and critical issue. It is also evident that methods employed for collecting data for cloud storage exert additional load on different cloud servers operated by many enterprises. Various approaches are used these days to reduce the burden on computer servers. One such approach is de-duplication, which has gained much attention due to its efficient, extensive storage system. In this approach, redundant data is removed, which improves storage utilization and reduces the cost of secure storage. International Data Corporation (IDC) reported 33 Zettabytes in 2018 to 175 ZB by 2025, putting cumbersome loads on present servers. Due to this enormous amount of data, it is challenging for the local and small servers, usually used in various enterprises, to handle it. It has also been observed that most data are generally duplicated in terms of space; therefore, data transmission places extra effort on small servers. This study provides a more comprehensive analysis of the literature on safe data duplication. Furthermore, it classifies the various secure data storage techniques applied at different levels of encrypted data collecting storage. Furthermore, this article looks into the classification of the de-duplication procedures as per literature and other Unified Modeling Language (UML) activity diagrams, exhibiting both their classification and detection difficulties. Moreover, current duplication techniques suffer from a couple of security challenges. Therefore, a convergent encryption algorithm has been proposed and implemented along with the de-duplication techniques, and the different UML diagrams and comparative analysis have illustrated the proposal's viability.
Dyslipidemia and metabolic syndrome among apparently healthy adolescents in Nigerian Secondary Schools: A Preliminary Investigation
Authors: Holdbrooke Susan , Afolabi Bamgboye Morakinyo 
Published: December 2022

Abstract
Introduction:
Metabolic syndrome (MetS), a group of risk factors that occur together, increases the possibility of heart disease, stroke, and type 2 diabetes. In MetS, blood pressure and blood sugar are elevated, excess body fat accumulate around the waist and there is dyslipidemia (abnormally high blood cholesterol levels). Most of the disorders related with MS have no symptoms.
Objective
To determine the prevalence of dyslipidemia and other risk factors for metabolic syndrome among apparently health adolescents in Secondary Schools in Lagos, Nigeria.
Materials and Methods
An institution-based, cross-sectional, descriptive study was conducted from October 2019 to March 2020. Multi-stage sampling approach was used to recruit 624 adolescent students in secondary schools in Lagos State of Nigeria. Data were collected using a structured questionnaire and fasting venous blood samples were collected for serum glucose and lipid profile analysis. Systolic and diastolic blood pressures were appropriately measured. Data were analyzed using NCSS version 22 (Kaysville, Utah, USA). Relevant statistical analyses were performed and p-value < 0.05 was considered as statistically significant.
Results
Overall, the median values (mg/dl) of triglyceride (TG), total cholesterol (T-Chol), low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol (HDL-C) were 180.8, 199.4, 289.6 and 55.9 respectively. Isolated lipid profile abnormality of hypertriglyceridemia, hypercholesterolemia, high level of low-density lipoprotein (LDL-C) and low level of high-density lipoprotein (HDL-C) were observed in 70.5%, 49.7%, 85.9%, and 24.7% study participants. The overall prevalence of metabolic (MetS) was 5.9%) more frequent among males 7.5%, mid-adolescents (8.2%) and among overweight subjects (20.0%).
Conclusion
Fasting blood sugar and lipid profiles as well as blood pressure and anthropometric indices of adolescents in secondary schools were evaluated for dyslipidemia and metabolic syndrome. A high proportion of them presented with hypertriglyceridemia and metabolic syndrome, especially males, those in mid adolescents and those overweight. A nation-wide, multi-center and multi-disciplinary study of metabolic syndrome should be conducted, through implementation of routine screening, for early recognition of and appropriate intervention measures on, identified risk factors, and for the treatments and prevention of metabolic syndrome in adolescents.
Analysis of associated factors with success of bariatric surgery: rs1800497 ANKK1, rs1799732 DRD2 genetic polymorphisms, eating behavior, hedonic hunger, and depressive symptoms
Authors: Daza-Hernandez Edgar Steven , Perez-Luque Elva , Cordero Claudia Martínez , Figueroa-Vega Nicte , Muñoz-Montes Norberto 
Published: December 2022

Abstract
Introduction:
Obesity is considered a risk factor for other chronic illnesses, such as type 2 diabetes mellitus, hypertension, dyslipidemia, cardiovascular diseases, and other disorders. A therapeutic approach is bariatric surgery (BS), which is considered the most effective intervention for severe obesity and ameliorates these comorbidities. Some polymorphisms are considered markers for addictive disorders and hedonic hunger and are associated with BMI. The objective was to analyze factors associated with the success of BS, including rs1800497 ANKK1 and rs1799732 DRD2 polymorphisms, eating behavior, hedonic hunger, and depressive symptoms.
Methods
We included 101 patients who underwent BS from 2010 to 2021 from the surgery service of a public hospital. We registered anthropometry and applied 3 questionnaires to evaluate eating behavior (TFEQ-R18), hedonic hunger (PFS), and depressive symptoms (PHQ-9). We typed the ANKK1 rs1800497 and rs1799732 DRD2 polymorphisms and evaluated biochemistry characteristics.
Results
The median weight loss was 34.7 kg with a BMI of 33.8 kg/m2. Weight loss was negatively associated with triglycerides (p = 0.011) and positively associated with the TFEQ-R18 (p = 0.006). Regarding polymorphisms, rs1800497 ANKK1 was associated with TFEQ-R18 (OR = 1.13 (1.02–1.25), p = 0.009), but rs1799732 DRD2 was not associated with either studied variable. We also found a negative correlation of actual BMI with scholarship (r=-0.29, p = 0.02).
Conclusion
We observed an improvement in metabolic and anthropometric parameters post-BS. Interestingly, the ANKK1 Taq1A polymorphism was associated with eating behavior, and scholarship with BMI could consider predictors of BS outcomes.