bluuebunny/crossref_metadata_2025_split huggingface dataset:
Investigation of synoptic patterns of fire occurrence in Humid Climates (Case Study: the forests of the western Alborz Mountains)
Authors: Keikhosravi Ghasem , Dizaj Ameneh Yahyavi 
Published: April 2022

Abstract
The present study was conducted in order to identify the predominant synoptic patterns of fire occurrence in the western Alborz Mountains. For this purpose, first the days of fire were obtained from the Department of Natural Resources of Gilan Province and product (MCD14) Modis sensor (2007–2020). The longitude and latitude of the affected regions was added to GIS and the spatial database of the fire was prepared. In order to determine atmospheric synoptic patterns, atmospheric maps were obtained from NCEP / NCAR site on all fire days with a spatial resolution of 2.5 * 2.5 degree. Totally, 240 fires occurred in the study area during this 14-year period. Among the months of the year, July, August and December have the highest incidence of fires with the occurrence frequency of 38, 37 and 24 days, respectively. Based on the fires that occurred, the three predominant synoptic patterns have the highest frequency of fires, which are 1) Saudi-African high-pressure dominant in the hot and cold seasons of the year, with three forms of omega blocking (16.5%), ridge (24.8%) and intrusion (22.2%), in total with a frequency of 63.5%, 2) European Migrant high-pressure system intrusion dominant in the hot period of the year, with a frequency of 21.7% and 3) Sub polar low-pressure which is generally dominant during the cold period of the year and responsible for about 14.8% of the fires in the region.
Knowledge and Confidence Levels Improvement Among Obstetrics Residents Regarding Caesarean Section Training Using Video- Mannequins Combination
Authors: Kurniawati Eighty Mardiyan , Bachtiar Citra Aulia , Joewono Hermanto Tri , Utomo Budi 
Published: April 2022

Abstract

Background: Elevating rates of caesarean section was happened in around the world nowadays. The health professionals are required to expert in this surgery in order to provide safely procedures, especially obstetrics and gynecology residents. However, Covid-19 emergence became a barrier of residents to practice their surgery skills. Consequently, it had to discover alternative strategies for residents to achieve caesarean section skills. This study’s purpose was to identify the effect of virtual video, mannequins, and the combination of video-mannequins on resident’s knowledge and confidence regarding caesarean section. Method: This research was a quasy-experimental study with pre-test and post-test designs. Based on stratified random sampling, this research involved 33 obstetrics and gynecology residents as study respondent. These samples were divided into 3 groups. These three groups received different interventions, such as learning using video, mannequins, and video-mannequins combination. This study used 2 kinds of questionnaires to examine resident’s knowledge and their confidence level. The collected data was analysed further employing three statistical tests, such as Wilcoxon-Signed Ranked Test, Kruskal Wallis Test, and Mann Whitney Test. Result: This study consisted of 4 levels of residentials according to their semester periods. More than half respondents had more than three times clinical experiences in the hospital related to the obstetrics and gynecology sciences. All the study methods such as video tutorial (0.42(CI95%-0.11-0.9)), mannequin simulation (0.60(CI95%-0.04-1.25)), and the combination of video-mannequin (1.3(CI95%0.73-1.93)) significantly increased resident’s knowledge. Besides, video and mannequin learning methods could increase resident’s confidence due to caesarean surgery practice. Conclusion: All media could improve resident’s knowledge about caesarean section clinical practice. The combination of video tutorial and mannequin simulation became the best method to achieve competency in caesarean surgery, compared to the single video tutorial and mannequin simulation. In addition, these educational strategies enhanced resident’s confidence during clinical practice of caesarean section.
Health related quality of life (HRQoL), anxiety and depression in patients with desmoid type fibromatosis (DTF): a prospective cross-sectional study from tertiary care centre in India
Authors: Garg Vikas , Rastogi Sameer , Kalra Kaushal , Bhoriwal Sandeep , Barwad Adarsh , Dhamija Ekta , Upadhyay Ashish , Gamangatti Shivanand 
Published: April 2022

Abstract
Introduction: Patients with desmoid type fibromatosis (DTF) suffer from emotional distress and impaired health-related quality of life (HRQoL) due to long disease course, and unpredictable growth patterns. Worldwide data on the impact of DTF on emotional distress and HRQoL is sparse. In this study, we assessed the impact of DTF on HRQoL, anxiety, and depression.Methodology: This was a prospective cross-sectional study done in patients with DTF and healthy controls. The study participants were asked to fill the EORTC QLQ-C30, GAD-7, and PHQ-9 questionnaires to assess HRQoL, anxiety, and depression respectively. The primary objective was to determine HRQoL and the secondary objectives were to determine anxiety and depression in patients with DTF and to determine any difference in HRQoL, anxiety, and depression between DTF patients and healthy controls.Results: Two hundred four subjects (102 DTF patients and 102 healthy controls) were recruited. The median age of DTF patients at recruitment into the study was 31 years (IQR, 25-37 years). There was a female preponderance with a male: female ratio of 1: 1.83. Appendicular skeleton and abdomen sites were most commonly involved in 59 % and 22.5 % respectively. About half (54 %) of patients were currently on sorafenib and 41 % were under active surveillance. The mean global health status in DTF patients was 65.58 ± 22.64, significantly lower than healthy controls. Similarly, DTF patients scored low on all functional scales except cognitive functioning. The symptom scale showed a significantly higher symptom burden of fatigue, pain, insomnia, and financial difficulties. Anxiety & depression was observed in 39.22 % and 50 % of DTF patients respectively. DTF patients had higher rates of mild, moderate, and severe anxiety and depression compared to healthy controls.Conclusion: DTF patients have significant symptom burden, poor functioning, and heightened anxiety and depression as compared to healthy controls. HRQoL, anxiety, and depression should be routinely used to assess symptom burden and treatment efficacy in DTF patients.
Phyto-Fenton remediation of a dichloro-diphenyl-trichloroethane contaminated site in Ha Tinh Province, Vietnam
Authors: Dang Minh Hieu , Vo Huu Cong , Inagaki Yoshihiko , Dao Thi Nhung , Tran Dinh Trinh , Tran Minh Thao , Nguyen Thi Thinh , Ho Thi Thuy Hang , Tran Duc Vien , Sakakibara Yutaka 
Published: April 2022

Abstract
A field trial was conducted at a site in Cam Binh commune, Ha Tinh province, Vietnam, highly contaminated with organo-pesticides. The phyto-Fenton process was applied to remove pesticide residues in soil. In addition to magnetite (Fe3O4) materials added to the soil, fertilisers and elicitors for oxidative burst were also added in the different experimental treatments. Dichloro-diphenyl-trichloroethane (DDT) and isomers were removed in all experimental lots. Removal efficiency was highest in lot B1, a site where only iron materials were added. The removal efficiency and the final content of DDTs in B1 were 98.4% and 0.009 mg kg-1, respectively. These values were markedly better than those achieved by another phyto-Fenton trial in 2017. In the presence of elicitors, the conversion of DDT to dichlorodiphenyldichloroethylene was more favourable. Analysis of soil properties indicated that the phyto-Fenton process can occur at neutral soil pH, and when there are only small changes in soil organic carbon content and cation exchange capacities. Shifts in the composition of the microbial communities were observed. Further studies on the interactions between materials added to soil, plants, and the soil microbiome are needed to understand the mechanism of action of the phyto-Fenton process during soil remediation.
FPIRPQ: Accelerating Regular Path Queries on Knowledge Graphs
Authors: Wang Xin , Hao Wenqi , Qin Yuzhou , Liu Baozhu , Liu Pengkai , Song Yanyan , Zhang Qingpeng , Wang Xiaofei 
Published: April 2022

Abstract
With the growing popularity and application of knowledge-based artificial intelligence, the scale of knowledge graph data is dramatically increasing. As an essential type of query for RDF graphs, RegularPath Queries (RPQs) have attracted increasing research efforts, whichexplore RDF graphs in a navigational manner. Moreover, path indexeshave proven successful for semi-structured data management. However,few techniques can be used effectively in practice for processing RPQon large-scale knowledge graphs. In this paper, we propose a novel indexing solution named FPIRPQ (Frequent Path Index for Regular PathQueries) by leveraging Frequent Path Mining (FPM). Unlike the existing approaches to RPQs processing, FPIRPQ takes advantage of frequentpaths, which are statistically derived from the data to accelerate RPQs. Furthermore, since there is no explicit benchmark targeted for RPQsover RDF graph yet, we design a micro-benchmark including 12 basicqueries over synthetic and real-world datasets. The experimental resultsillustrate that FPIRPQ improves the query efficiency by up to orders ofmagnitude compared to the state-of-the-art RDF storage engine.
Lipopolysaccharide Induces Mitochondrial Oxidative Stress and Accelerates Apoptosis by Activating ROS/NF-κB in Osteoarthritis Chondrocytes
Authors: Liu Su , Li Guoqing , Qi Tiantian , Chen Yixiao , Xiong Ao , Weng Jian , Yu Fei , Zeng Hui 
Published: April 2022

Abstract
Background. Chondrocyte apoptosis plays a significant role in the pathogenesis of osteoarthritis (OA), but the mechanism remains unclear. This research aimed to elucidate the effect of mitochondrial oxidative stress on chondrocyte apoptosis through ROS/NF-κB pathway. Methods. Mouse chondrocytes exposed to lipopolysaccharide (LPS) were used as OA models in vitro. Cell viability was tested by CCK-8. Cell proliferation, apoptosis, reactive oxygen species (ROS), and mitochondrial membrane potential were detected by fluorescence microscopy or flow cytometry. Contents of superoxide dismutase (SOD), catalase (CAT), glutathione (GSH), and adenosine triphosphate (ATP) were evaluated by biochemical detection. Ultrastructure of mitochondria was observed by transmission electron microscope (TEM). Relative mRNA and protein expression were detected by quantitative polymerase chain reaction (qPCR) and western blot. Results. LPS increased the level of ROS and activated the NF-κB pathway, which decreased cell viability, inhibited the activity of SOD/CAT/GSH, and induced mitochondrial oxidative stress. The disturbance of mitochondrial homeostasis decreased mitochondrial membrane potential and adenosine triphosphate (ATP), which eventually accelerated apoptosis. The ultrastructure of mitochondria changed with swelling, intrinsic vacuole, and deformed cristae after treated by LPS. These LPS-induced effects were attenuated by Pyrrolidinedithiocarbamate ammonium (PDTC, an NF-κB inhibitor) and N-acetylcysteine (NAC, an antioxidant). Conclusions. LPS can induce mitochondrial oxidative stress and accelerate apoptosis through the ROS/NF-κB pathway. As mitochondrial dysfunction is an early sign of apoptosis, regulating the redox state of chondrocytes and maintaining mitochondrial homeostasis may provide novel ideas for the early treatment of OA.
Triglyceride-Glucose Index Variability and Incident Cardiovascular Disease: A Prospective Cohort Study
Authors: Li Haibin , Chen Shuohua , Qian Frank , Tian Xue , Zuo Yingting , Li Xia , Guo Xiuhua , Wu Shouling , Wang Anxin 
Published: April 2022

Abstract
Background: Recent studies have suggested that triglyceride-glucose (TyG) index is an independent predictor of cardiovascular disease (CVD). However, the impact of long-term visit-to-visit variability in TyG index on risk of CVD is not known. We aimed to investigate the longitudinal association between baseline and mean TyG index as well as TyG variability and incident CVD in a Chinese population.Methods: We included 52,925 participants without previous history of CVD in the Kailuan study who underwent three health examinations (2006, 2008, and 2010) and were followed-up for clinical events until 2019. TyG index was calculated as Ln [fasting triglyceride (mg/dL) × fasting glucose (mg/dL)/2]. We measured the TyG variability as the SD of the residuals obtained from a linear regression on the three TyG measurements for each individual. Multivariate-adjusted Cox models were used to estimate the adjusted hazard ratio (aHR) and 95% confidence interval (CI).Results: During a median follow-up time of 9.0 years, 2,745 developed CVD. The highest tertile (T3) of baseline and mean TyG index were each associated with higher CVD incidence as compared with the lowest tertile (T1) group: aHR, 1.35; 95% CI, 1.20-1.51; and aHR, 1.42; 95% CI, 1.27-1.60, respectively. Tertile 3 of TyG variability was associated with increased CVD incidence compared to T1 group (aHR, 1.13; 95% CI, 1.03-1.24). Individuals in the highest tertile of baseline TyG and the highest tertile of TyG variability experienced the highest incidence of CVD (aHR, 1.30; 95% CI, 1.10-1.53). Conclusion: Higher TyG level and greater TyG variability were each independently associated with a higher incidence of CVD.
Risk and prognosis of secondary bladder cancer after radiation therapy for pelvic cancer
Authors: Li Shuofeng , Wei Ran , Yu Guanhua , Guan Xu , Wang Xishan , Jiang Zheng 
Published: April 2022

Abstract
Background
This study aimed to identify the relationship between radiation therapy (RT) received for the treatment of primary pelvic cancer (PC) and subsequent secondary bladder cancer (SBC).
Methods
The SEER database was queried for PC. Fine-gray competing risk and Cox regression analyses were employed to assess the cumulative incidence of SBC. Poisson regression and multiple primary standardized incidence ratios (SIR) were used to evaluate the radiotherapy-associated risk for patients receiving RT. Subgroup analyses of patients stratified by latency time since PC diagnosis, calendar year of PC diagnosis stage, and age at PC diagnosis were also performed. Overall survival (OS) was compared among different treatment groups with SBC by Kaplan–Meier analysis.
Results
A total of 318,165 observations showed that the primary cancers were located in pelvic cavity, 256,313 patients did not receive radiation therapy (NRT), 51,347 patients who underwent external beam radiation therapy (EBRT), and 10,505 patients receiving a combination of EBRT and brachytherapy (EBRT–BRT) who developed SBC. Receiving two types of RT was strongly consistent with a higher risk of developing SBC for PC patients in Fine-Gray competing risk regression (NRT vs. EBRT, adjusted HR = 1.71, 95% CI: 1.54–1.90, P < 0.001; NRT vs. EBRT–BRT, adjusted HR = 2.16, 95% CI: 1.78–2.63, P < 0.001). The results of the dynamic SIR and Poisson regression analysis for SBC revealed that a slightly increased risk of SBC was observed after RT in the early latency and was significantly related to the variations of age at PC diagnosis and decreased with time progress. For OS, the SBC after NRT, SBC after EBRT, and SBC after EBRT-BRT of 10-year survival rates were 37.9%, 29.2%, and 22.2%, respectively.
Conclusions
Radiotherapy for primary PC was associated with higher risks of developing SBC than patients unexposed to RT. Different pelvic RT treatment modalities had different effects on the risk of SBC.
New insights into the evolution of portunoid swimming crabs (Portunoidea, Heterotremeta, Brachyura) and the brachyuran axial skeleton
Authors: Hazerli Dennis , Höpel Christoph Gert , Richter Stefan 
Published: April 2022

Abstract
Portunoidea (Heterotremata) represents a morphologically disparate taxon of true crabs (Brachyura), best-known for many of its representatives being considered as “swimming crabs”. This term, however, sometimes refers to a distinct taxon (traditionally to Portunidae within Portunoidea), but sometimes also to a certain morphotype, with the 5th pereiopod (P5) having the shape of a specific swimming leg. We herein use the term “P5-swimming crab” or “P5-swimmer”, not only to restrict it to the morphotype, but also to distinguish it from other kinds of swimming in Brachyura. The evolution of P5-swimming crabs is still poorly investigated. For example, it is not known, whether the morphotype evolved several times independently in different lineages of Portunoidea or if it evolved only once and had been lost in several lineages. We here present the first approach combining molecular with morphological data resulting in a new phylogenetic hypothesis of Portunoidea. For the first time, the latter involve data from the axial skeleton and extrinsic musculature. Morphological examinations revealed that axial skeleton and extrinsic musculature in P5-swimming crabs were more diverse than previously thought, except for the origin of the P5 anterior coxa muscle origin at the median plate, which was present in all P5-swimmers. Ancestral state reconstructions based on parsimony revealed that the stem species of Portunoidea already showed the morphotype of a P5-swimming crab, but with a long merus which probably resulted in a less effective P5-swimming ability compared to that of extant P5-swimming crab species with short merus. Several other extant taxa represent a reversal of the P5-swimmer morphotype with variable degree, with some extant species showing a complete reversal of unambiguous P5-swimming crab character states, like for example the common shore crab Carcinus maenas. Finally, a missing connection of interosternite 7/8 to the sella turcica (the secondary loss of the “brachyuran sella turcica”) in the stem species of Heterotremata, resulting in a junction plate forming a cavity that offered room and attachment sites for the P5 extrinsic musculature is uncovered as preadaptation to the P5-swimmer morphotype in Heterotremata, which is missing in “Podotremata" and Thoracotremata, the other two traditional main taxa of Brachyura.
Comparative analysis of three common imaging modalities in nasolabial cyst
Authors: Liu Shengyang , Hao Dingqian , Wu Yisha , Li Ping , Ma Hui , Zhao Hui , Sun Shujuan , Yu Peng , Yu Liang , Chen Aiping , Ji Hongzhi , Wan Yuzhu , Shi Li 
Published: April 2022

Abstract
Objectives: To compare the clinical diagnostic value of ultrasonography (USG), computed tomography (CT) and magnetic resonance imaging (MRI) in nasolabial cyst.Methods: The clinical and imaging data of 20 patients with nasolabial cyst confirmed by operation and histopathology were analyzed.Results: The largest cyst was 3.4cm×2.7cm×2.3cm while the smallest one was 1.1cm×0.7cm×0.5cm. All cysts were located in the soft tissue between nasolabial fold and maxilla bone. USG: sensitivity was 95%, accuracy was 95% and missed diagnosis rate was 5%; CT: sensitivity was 80%, accuracy was 80% and missed diagnosis rate was 20%; MRI: sensitivity was 85%, accuracy was 85% and missed diagnosis rate was 15%.Conclusions: Compared with CT and MRI, sensitivity and accuracy of USG are higher and missed diagnosis rate is lower, so it is worth popularizing on a large scale in the diagnosis of nasolabial cyst.
The effect of Mir-181a-5p on the prognosis of LUAD patients through targeted regulation of GTSE1 expression
Authors: Yang Xitong 
Published: April 2022

Abstract
Backgroud：Studying the regulatory mechanism and clinical application of target genes in LUAD can further provide theoretical basis. Methods: LUAD expression data were downloaded from the UCSC database, miRNA data were obtained from the TCGA database, and DEGs were derived by analyzing expression data using R software. The genes associated with LUAD were then obtained by survival analysis, and among them, clear LUAD target genes were screened. In-depth analysis of the GEPIA database yielded differences in normal and tumor tissues of LUAD patients, while comparing DFS and OS of target genes in LUAD. The Relevant IncRNA was derived from mRNA and miRNA analysis, and the correlation between immune cell content and target gene copy number, as well as the correlation between target genes and immune checkpoint-related genes CD274, PDCD1 and CTLA4 were analyzed by Timer database. Results: The results indicated that GTSE1 expression was significantly higher in LUAD tumor tissues than normal tissues, and the survival rates of OS and DFS were significantly lower in patients with high GTSE1 expression than in the low expression group. GSEA analysis of GTSE1 was mainly involved in LUAD through Biocarta ranms pathway. According to the R software, mir-181a-5p was the GTSE1 target miRNA and GTSE1 gene expression was negatively correlated with mir-181a-5p expression. In addition, GTSE1 was positively correlated with CD274, PDCD1, and CTLA4 immune checkpoints. Conclusion: The mir-181a-5p is a target miRNA of GTSE1 and mir-181a-5p expression is positively correlated with patient survival.
Adiposity, lipid metabolites, statins use and sleep apnea syndrome risk: a Mendelian randomization study
Authors: Wang Feng , Zhang Qiang 
Published: April 2022

Abstract
BackgroundBody mass index can not fully reflect obesity. The aim of the study was to verify the prognostic significance of obesity on sleep apnea syndrome using body fat percentage (BFP) and waist-to-hip ratio (WHR), and to further explore the effect of lipid metabolites on the disease risk.MethodsGenetic variants from genome-wide association studies for BFP, WHR, ten lipid metabolites (including saturated fatty acid) and three statins (exposures) were used as instrumental variables. Two-sample and multivariate Mendelian randomization methods were adopted to determine the causal association of exposures mentioned above with sleep apnea syndrome (outcome) risk. All statistical analysis was conducted by R software (version 3.5.2).ResultsMultivariate Mendelian randomization showed that higher BFP and WHR were associated with the increased risk of sleep apnea syndrome after adjusting for the other exposures (BFP: OR=1.40, 95%CI: 1.00~1.90; WHR: OR=1.36, 95%CI: 1.05~1.78). Multivariate analysis also found that higher saturated fatty acid was independently related to the elevated risk of the disease (SFA: OR=2.00, 95%CI: 1.08~3.70). However, multivariate analysis failed to confirm the potential relationships between the other exposures and sleep apnea syndrome risk.ConclusionThe study confirmed a causal association of systemic fat accumulation and abdominal obesity with development of sleep apnea syndrome. The study also provided some interesting evidences that saturated fatty acid might be one another risk factor for development of the disease. More importantly, the effect of obesity on the disease risk may be independent of lipid metabolites including saturated fatty acid.Trial registration: This was a Mendelian randomization study, and there was no results of a health care intervention on human participants.