bluuebunny/crossref_metadata_2025_split huggingface dataset:
The role of vitamin D receptor agonist on podocyte injury induced by high glucose
Authors: Wang Zhiyuan , Guo Jia 
Published: August 2022

AbstractBackgroundThe effects of vitamin D receptor (VDR) agonist paricalcitol on the podocyte injury induced by high glucose (HG) were investigated in conditioned immortalized mouse podocytes (MPC-5).Methods(1) Grouped according to different glucose concentrations: normal group (NG): 5.6 mmol/L glucose; HG stimulation group: 25 mmol/L glucose (25HG); high osmotic control group (NG+M): 5.6 mmol/L glucose + 19.4 mmol/L D-mannitol. The expression levels of VDR, podocyte marker proteins podocin, nephrin and mesenchymal marker proteins α-smooth muscle actin (α-SMA), matrix metalloproteinases (MMP9) in MPC-5 were measured, respectively. (2) Effect of VDR agonist-paricalcitol on podocyte epithelial-mesenchymal transition (EMT) induced by HG: cultured podocytes are divided into NG group, NG with dimethylsulfoxide (DMSO) group (NG+D), NG with paricalcitol (0.1 μmol/L) group (NG+P), HG group, HG with DMSO group (HG+D), and HG with paricalcitol (0.1 μmol/L) group (HG+P). The expression levels of VDR, podocyte marker proteins, marker proteins of mesenchymal cells, and the albumin flow in each group were then detected.Results(1) Under HG conditions, the expressions of VDR, podocin, and nephrin were decreased, while the expressions of α-SMA and MMP9 were increased (allP< 0.05). After administration of paricalcitol, the levels of VDR, podocin, and nephrin were increased, while the expressions of α-SMA and MMP9 were decreased compared with the control groups (allP< 0.05). (2) The results of albumin flow showed that the albumin flow of podocytes increased under the condition of HG, while it decreased after the treatment of paricalcitol.ConclusionThe podocyte injury induced by HG could be partly rescued by Paricalcitol.
Role of Double Balloon Enteroscopy in the Diagnosis of Obscure Gastrointestinal Bleeding
Authors: Aziz Segal Abdul , Makmun Dadang 
Published: August 2022

Obscure gastrointestinal bleeding (OGIB) is bleeding in the digestive tract which persist or recur and with unclear aetiology. OGIB is one of the important problems in the gastrointestinal field due to difficulty in diagnosing the aetiology and determining the source of digestive tract bleeding in patients. In diagnosing the cause of OGIB, clinical approach through history taking and physical examination still have important roles. Most of the sources of bleeding in OGIB is from the small intestine, which cannot be reached by esophagogastroduodenoscopy (EGD) or colonoscopy. Therefore, role of diagnostic tool which is able to perform total enteroscopy becomes important in diagnosing the cause of OGIB.Double balloon enteroscopy (DBE) technique is a safe endoscopy procedure which may use oral or even rectal approach. In finding the cause of OGIB, where most of the lesions is found in the proximal region of the small intestine, oral approach is more beneficial. When bleeding is not found after conventional endoscopy is performed, it needs to be suspected that the source might come from the small intestine. Currently, the two main modalities which can be used in the evaluation are video capsule endoscopy (VCE) and DBE. However, based on cost effectiveness DBE without prior VCE has benefit because it can also administer therapy in the abnormalities being found. Keywords: obscure gastrointestinal bleeding, endoscopy, diagnosis, double balloon enteroscopy
Mirizzi Syndrome in Gallstone Complication
Authors: Perbowo Ario , Makmun Dadang 
Published: August 2022

Mirizzi syndrome is a rare complication of gallstone which is characterized by the presence of gallstone impaction in cystic duct that leads to inflammatory stricture in the biliary duct and results in obstructive jaundice. In this report, we highlighted the diagnostic approach and management of Mirizzi syndrome in a 58 year-old male complaining of nausea, vomiting, and appearing jaundice. The role of imaging such as abdominal ultrasonography in depicting the characteristics of Mirizzi syndrome was also discussed and compared the findings with the classification of the disease in the literature. In this patient, Mirizzi syndrome was suspected by the appearance acoustic shadow in the gallbladder with dilated cystic duct suggesting the impaction of common bile duct (CBD). We performed endoscopic retrograde cholangiopancreatography (ERCP) as both diagnostic and therapeutic modalities by which we allowed sphingterectomy to evacuate the gallstone. However, due to the risk of further stone evacuation, the procedure was followed by elective cholecystectomy. Keywords: gallstone, Mirizzi syndrome, complication
Conformity between Ileoscopy Appearance with Terminal Ileum Histopathology Appearance in Normal Colonoscopy Chronic Diarrhea Patients
Authors: Marki Indra , Syam Ari Fahrial , Hasan Irsan 
Published: August 2022

Background: Chronic diarrhea is one of the most common problem in gastroenterology cases. Ileoscopy is one of the modalities to determine the etiology of chronic diarrhea by normal colonoscopy appearance. Recently, there is still controversy in the need of this examination in normal macroscopic appearance. The aim of this study is to study the conformity of histopathology abnormalities with ileoscopy appearance in chronic diarrhea patients with normal colonoscopy.Methods: This study uses cross sectional study design by collecting 60 medical record data in several hospitals in Jakarta in the period of 1 January 2005 to 31 December 2011. Diagnostic test between ileoscopy and histopathology is performed by histopathology examination as a gold standard.Results: Study results revealed conformity between both examinations for 93.33%. Sensitivity value of ileoscopy examination compared to histopathology as a gold standard was 94%, specificity 90%, positive predictive value 97.9%, and negative predictive value 75%.Conclusion: Ileoscopy examination in chronic diarrhea patients and normal colonoscopy showed similar results with histopathology examination. Keywords: Ileoscopy, histopathology, conformity, chronic diarrhea
Soy Infant and Extensively Hydrolyzed Formula as Therapeutic Formula for Cow’s Milk Protein Allergy
Authors: Reynaldo Aldo , Hegar Badriul 
Published: August 2022

Cow’s milk protein allergy (CMPA) is a food allergy mostly suffered by children aged 3 years that can be mediated by IgE or non-IgE or both. The prevalence of CMPA in children is heterogeneous between populations. Meta-analysis study showed that the prevalence was 2-3% in infants and 1% in children aged 6 years. Although the prevalence is quite small but proper management is very important because it affects the quality of life of children and to avoid the risk of anaphylactic reaction that threatens life. Therapy for CMPA is to avoid cow's milk protein and its derivatives; it is also recommended for breast-feeding mothers to do the same. Therapeutic milk formulas that can be given is extensively hydrolyzed formula (eHF) or soy infant formula (SIF). The selection of formula became adebate, especially about the safety, effectiveness and cost. Keywords: cow milk protein allergy, soy infant formula, extensively hydrolyzed formula
Role of Phytopharmacy as Hepatoprotector in Chronic Hepatitis
Authors: Herlianto Budi , Mustika Syifa , - Supriono - , Pratomo Bogi , Achmad Harijono 
Published: August 2022

Background: Hepatitis is one of the health problems in Indonesia that require special treatment, in line with the increase of morbidity and mortality rate of this disease. Complications of hepatitis include liver cirrhosis and hepatocellular carcinoma. Indonesia, as a tropical country, has many medicinal plants that act as hepatoprotector, a substance that can protect liver from toxic agent. Use of medicinal plants is still considered as controversial treatment because there is still lack of studies. Medicinal plants with mix composition of phytopharmacy, such as: Curcuma xanthorrhiza, Arcangelesia flava, Nigella sativa, and Kleinhovia hospita show potency as hepatoprotector. The objective of this study is to analyse the function of phytopharmacy as hepatoprotector in chronic hepatitis.Method: This study is a clinical trial performed in the Gastroenterology Department and Outpatient Clinic in Saiful Anwar Hospital in May-June 2013. Chronic hepatitis B or C patients who have received antiviral therapy with 3 fold increase of the threshold value of transaminase level, were included in this study. In this study, patients consumed phytopharmacy tablet 3 times per day. After 7 days of treatment, patients’ serum transaminase levels (ALT and AST) were re-assessed. Statistical analysis of before and after treatment data was performed using Wilcoxon test and the result was significant with p 0.05.Results: From 10 patients, the average age was 50.3 years old. Sixty percent (60%) of them were male, with 50% suffered from chronic hepatitis B and the other 50% suffered from chronic hepatitis C. From this study, decrement of alanine transaminase (ALT) and aspartate transaminase (AST) after seven days of treatment were 45.06%, with p = 0.007 and 48.63%, with p = 0.007, respectivelyConclusion: Phytopharmacy supplementation in chronic hepatitis can decrease serum transaminase, however further study is needed. Keywords: chronic hepatitis, phytopharmacy, ALT, AST, hepatoprotector
Prevention of Hepatitis B Virus Transmission in Pregnancy
Authors: Praptiwi Dwi Rahayu NL , Sanityoso Andri 
Published: August 2022

Chronic hepatitis B virus infection is a serious health problem in many countries, particularly in developing countries. In Asia-Pacific region, vertical transmission from mother to child is the main endemicity factor of hepatitis B virus (HBV) infection. Almost 50% cases of hepatitis B virus infection happen during perinatal and neonatal period, including vertical transmission from mother to child during pregnancy.World Health Organization (WHO), World Gastroenterology Organization (WGO) and many countries have recommended immunoprophylaxis by the administration of hepatitis B vaccine and hepatitis B immunoglobulin (HBIg) to prevent transmission from mother to child. However, there are approximately 10-15% babies born from mother with hepatitis B infected by HBV through intrauterine transmission. Incidence of intrauterine transmission is accounted for around 43-50% if DNA of HBV in the mother is more than 107 copies/mL, although passive and active immunization to the baby has been administered. Therefore, administering antiviral drugs in pregnant women with chronic hepatitis B accompanied by immunoprophylaxis is effective in preventing hepatitis B infection transmission during pregnancy, particularly in decreasing the number of virus and administering active or even passive immunization to neonates. Keywords: hepatitis B, pregnancy, prevention, transmission
Chronic Radiation Proctosigmoiditis in Patients with Cervical Cancer
Authors: - Juliyanti , Makmun Dadang 
Published: August 2022

Complications in rectum and sigmoid due to radiation are usually called radiation proctosigmoiditis. It can be acute or chronic based on the onset of symptoms during radiation treatment. There are some treatment modalities aimed for reducing rectosigmoid bleeding and improving symptoms of chronic radiation proctosigmoiditis, which include medication, endoscopy and surgery. Most data about the effectiveness of those various modalities are provided by short-term studies with small sample size.A female patient, 59 years old, came with a chief complaint of passing persistent fresh bright red bloody stool since 1 year before admission. The patient was then diagnosed with stage IIIB cervical cancer and she received 25 times of external radiation, 3 times of internal radiation and 3 times of chemotherapy. She was diagnosed with chronic radiation proctosigmoiditis and treatment to stop the bleeding was carried out by performing argon plasma coagulation through colonoscopy. The problems in the patient were formulated as chronic radiation proctosigmoiditis with malnutrition and iron deficiency anemia due to chronic bleeding. Non-pharmacological and pharmacological medications were administered.Keywords: radiation proctosigmoiditis, argon plasma coagulation, medication
Survival of Pancreatic Cancer Patients in Dr Cipto Mangunkusumo National Referral Hospital Jakarta from November 2018 To December 2018
Authors: Renaldi Kaka , Fatya Atikah Isna , Sakinah Sharifah 
Published: August 2022

Background: Pancreatic cancer is a leading cause for cancer deaths worldwide and its survival rate remains low. The one year- and five year-survival rate remain as low as 21% and 6-8% consecutively. Little is known about the survival rate of pancreatic cancer in Indonesia. This study aims to evaluate the survival rate of pancreatic cancer patients at Gastrointestinal Endoscopy Center, National Referral Hospital Dr. Cipto Mangunkusumo, Jakarta, during November 2018 to December 2018.Method: This retrospective cohort study extracted the registry data of newly diagnosed pancreatic cancer patients between November 2018 to December 2018 from the Gastrointestinal Endoscopy Center, Cipto Mangunkusumo Hospital, Jakarta. All patients were followed since they were diagnosed to two months after diagnosis or 31st December 2018 or to their date of death, whichever came first.Results: We found 12 newly diagnosed pancreatic cancer cases between November 2018 to December 2018. The mean age at diagnosis was 55 years old, with 58% male, 50% sundanese, and 75% patient come from low educated level. About 58% cases presented with cholangitis, and the mean bilirubin concentration at diagnosis was 26 mg/dL. All patient came with an obstructive jaundice symptoms, and 91% had endoscopic biliary drainage procedure. After 2 months of observation, we found 16% patient died due to unresolved infection.Conclusion: There were 12 cases of pancreatic cancer, of which 16% pancreatic cancer patients died within 2 months of follow up. Infection is the main cause of morbidity and mortality in pancreatic cancer patients.
Decreased in Liver Fibrosis in Patients with HCV/HIV Coinfection After Treatment with Sofosbuvir/Daclatasvir
Authors: Jonathan Andreas , Wisaksana Rudi , Agustanti Nenny 
Published: August 2022

Background: Hepatitis C Virus (HCV)/Human Immunodeficiency Virus (HIV) co-infection increases the progression of liver fibrosis to advanced liver disease and death. The aim of this study is to determine whether decreased of liver fibrosis occur in HCV/HIV coinfection patients after therapy with Sofosbuvir/daclatasvir. Method: This study used a quasi-experimental study design without a control group. The study subjects were HCV/HIV coinfection patients who received Sofosbuvir / daclatasvir therapy in the Gastroentero-Hepatology Clinic of Dr. Hasan Sadikin Hospital. In this study measurement of liver fibrosis was carried out by using AST to Platelet Ratio Index (APRI) and Fibrosis-4 Index (FIB-4) before therapy and when SVR-24 was achieved.Results: The study involved 29 subjects. Most of the research subjects were men, with an average age of 40.38 years (SD 3.48). From the results of this study, we found a decrease in APRI scores and FIB-4 index when HCV / HIV coinfection patients, that were treated with Sofosbuvir/ Daclatasvir, achieved SVR 24. The median of APRI scores before therapy and after SVR-24 was decreased from 0.41 to 0.28 (95% CI: 0.01 - 0.23, p-value 0,01) and the median of FIB-4 Index before therapy and after the SVR 24 was decreased from 0.94 to 0.81 (95% CI: -0, 04 - 0.35, p-value 0.28).Conclusion: This study concluded that therapy using Sofosbuvir / Daclatasvir in HCV / HIV coinfected patients has very good effectiveness and can reduce liver fibrosis.
Analisis Kinerja Keuangan Pemerintah Daerah Kabupaten Banyuwangi Tahun Anggaran 2018-2020
Authors: Rizqi Amalia Hilda , Yudha Pratiwi Berlina 
Published: August 2022

This study aims to analyze the financial performance of the Banyuwangi Regency Government in 2018 to 2020 using financial ratio analysis. This research design uses descriptive qualitative. The population and samples taken are the 2018-2020 Banyuwangi Regional Government Financial Reports. Data were obtained by means of documentation, and literature study. The results show that the financial performance of the Banyuwangi Regency Government in the ratio analysis of the degree of decentralization in 2018-2020 shows less. In the analysis of the ratio of regional financial dependence in 2018-2020 is very high. In the analysis of the ratio of regional financial independence in 2018-2020 it is very low. In the analysis of the effectiveness ratio of regional original income (PAD) the average 2018-2020 shows less effective. In the 2018–2020 PAD efficiency analysis, it is very efficient. In the analysis of the compatibility ratio for 2018–2020, it shows that the amount of funds owned for operating expenses is 78.84% while operating expenses is 20.06%. The analysis of the growth ratio in 2018-2020 is fluctuating.

Penelitian ini bertujuan untuk menganalisis kinerja keuangan Pemerintah Daerah Kabupaten Banyuwangi pada tahun 2018 sampai 2020 dengan menggunakan analisis rasio keuangan. Rancangan penelitian ini menggunakan deskriptif kualitatif. Populasi dan sampel yang diambil adalah Laporan Keuangan Pemerintah Daerah Kabupaten banyuwangi 2018-2020. Data diperoleh dengan cara dokumentasi, dan studi pustaka. Hasil penelitian menunjukkan bahwa kinerja keuangan Pemerintah Daerah Kabupaten Banyuwangi pada analisis rasio derajat desentralisasi tahun 2018–2020 menunjukkan kurang. Pada analisis rasio ketergantungan keuangan daerah tahun 2018 – 2020 sangat tinggi. Pada analisis rasio kemandirian keuangan daerah tahun 2018–2020 rendah sekali. Pada analisis rasio efektivitas pendapatan asli daerah (PAD) rata-rata tahun 2018-2020 menunjukkan kurang efektif. Pada analisis efisiensi PAD tahun 2018–2020 sangat efisien. Pada analisis rasio keserasian tahun 2018–2020 menunjukkan bahwa besar dana yang dimiliki untuk belanja operasi sebesar 78,84% sedangkan belanja operasi 20,06%. Analisis rasio pertumbuhan tahun 2018–2020 bersifat fluktuatif.
Analisis Volume Saham Pada Saat Covid-19 Menggunakan Metode Regresi Dengan Teknik Imputasi
Authors: Adi Setiawan Adi Setiawan , Mubarak Fadhlul 
Published: August 2022

PT. Bintang Mitra Semestaraya Tbk is a subsidiary engaged in investment and trading. The company started as an investment company investing in real estate companies in developing basic housing projects, mid-range residential projects and companies developing commercial buildings. This study aims to determine the volume of shares in the company PT. Bintang Mitra Semestaraya Tbk during the Covid-19 pandemic. The stock data is simulated from 2020, 2021 and 2022 in daily form. This research only focuses on discussing the movement of stock values ​​during the Covid-19 pandemic and looking for some data related to Missing Value (missing or incomplete data) in the company's stock data using the imputation method. The correlation between data variables in simulations 1-8 as a whole has a significant correlation with the percentage of truth/trust in this study of 95%. Furthermore, in the regression model, the best model is seen from the parameter data, the smallest RSE is in simulation 6 and the largest RSE is in simulation 3

PT. Bintang Mitra Semestaraya Tbk adalah anak perusahaan yang bergerak di bidang investasi dan perdagangan. Perusahaan tersebut dimulai sebagai perusahaan investasi yang berinvestasi di perusahaan real estat dalam mengembangkan proyek perumahan dasar, proyek perumahan kelas menengah dan perusahaan yang mengembangkan bangunan komersial. Penelitian ini bertujuan untuk mengetahui volume saham pada perusahaan PT. Bintang Mitra Semestaraya Tbk di masa pandemi Covid-19. Data saham tersebut disimulasikan dari tahun 2020, 2021 dan 2022 dalam bentuk harian. Penelitian ini hanya berfokus membahas tentang pergerakan nilai saham selama masa pandemi Covid-19 dan mencari beberapa data terkait Missing Value (data hilang atau tidak lengkap) yang ada pada data saham perusahaan tersebut menggunakan metode imputasi. Korelasi antara variabel data pada simulasi 1-8 secara keseluruhan memiliki korelasi yang signifikan dengan persentase kebenaran/kepercayaan dalam penelitian ini sebesar 95%. Selanjutnya pada model regresi terdapat model terbaik yang dilihat dari data parameter RSE terkecil berada pada simulasi 6 dan RSE terbesar berada pada simulasi 3
IMPLEMENTASI PEMBELAJARAN E-LEARNING TERHADAP MOTIVASI BELAJAR SISWA SMP AL-ISLAH SURABAYA SELAMA COVID-19
Authors: Nur Fakky Fahrisal , Junjunan Mochammad Ilyas , Muflihin Mohammad Dliyaul , Muttaqin Muh. Syaukin 
Published: August 2022

AbstractIn 2020 the Indonesian ministry of education and culture decided to implement online learning activities in Indonesia, initially offline learning activities were changed to online learning activities due to avoid the spread of the COVID-19 pandemic. The purpose of this study was to determine the effect of the implementation of e-learning on students' learning motivation in schools in learning activities. This type of research uses a quantitative approach by distributing questionnaires to 8th-grade students at SMP Al-Islah Surabaya. A total of 55 students participated as research respondents. The results showed that the implementation of e-learning had a positive effect on students' learning motivation at Al-Islah Junior High School Surabaya. This shows evidence that the existence of learning that innovates because of the pressure of the situation still gives hope to educational institutions to continue to improve the quality and service of education to the community under any conditions. The limitation of this study is that it has a sample that is not large enough, so the results of the study cannot be fully generalized. And the opportunity for further research is to increase the research sample and develop research variables that become factors of student learning motivation such as the availability of information technology and teacher creativity innovation. Keywords: e-learning; COVID-19; learning motivation AbstrakPada tahun 2020 Kementerian Pendidikan dan Kebudayaan Indonesia memutuskan untuk memberlakukan kegiatan belajar mengajar secara daring di Indonesia, pada awalnya kegiatan belajar mengajar bersifat luring diubah menjadi secara daring dikarenakan untuk menghindari penyebaran pandemic COVID-19. Tujuan penelitian ini untuk mengetahui pengaruh implementasi pembelajaran secara e-learning terhadap motivasi belajar siswa di sekolah dalam kegiatan pembelajaran. Jenis penelitian ini menggunakan pendekatan kuantitatif dengan menyebarkan kuesioner kepada siswa kelas 8 di SMP Al-Islah Surabaya. Sebanyak 55 siswa berpartisipasi menjadi responden penelitian. Hasil penelitian menunjukkan bahwa implementasi pembelajaran e-learning berpengaruh positif terhadap motivasi belajar siswa di SMP Al-Islah Surabaya. Hal ini menunjukkan bukti bahwa keberadaan pembelajaran yang berinovasi karena desakan keadaan masih memberikan harapan kepada lembaga pendidikan untuk tetap meningkatkan kualitas dan pelayanan pendidikan kepada masyarakat dalam kondisi apapun. Keterbatasan penelitian ini adalah memiliki sampel yang tidak cukup besar, sehingga hasil penelitian belum bisa sepenuhnya di generalisasi. Dan peluang bagi penelitian selanjutnya adalah memperbanyak sampel penelitian dan mengembangkan variabel penelitian yang menjadi faktor motivasi belajar siswa seperti ketersediaan teknologi informasi dan inovasi kreativitas guru. Kata kunci: e-learning; COVID-19; motivasi belajar