bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cardiac Doppler Parameters and Progress in Clinical Manifestation of Primary Lower Extremity Varicose Veins: A Prospective Study in China
Authors: Zhang Jia , Wu Zhoupeng , Feng Qingbo , Huang He , Ma Yukui 
Published: February 2022

ObjectiveTo investigate the features of cardiac Doppler parameters in patients with primary lower extremity varicose veins in China.Materials and MethodsWe performed a prospective statistical analysis of cardiac Doppler parameters between 129 Chinese patients with varicose veins and normal controls. Furthermore, we evaluated the relationship between cardiac Doppler and the progress or severity of lower extremity varicose veins.ResultsCompared with normal controls, patients with primary varicose veins had significantly lower early mitral and tricuspid diastolic inflow and annular velocities (E- and e′-waves), significantly higher late mitral and tricuspid diastolic inflow and annular velocities (A- and a′-waves), significantly higher mitral systolic annular velocities (s′-wave), and significantly lower mitral and tricuspid E/A ratio. There was no significant association between deep venous reflux (DVR) of the lower extremities and cardiac Doppler parameters. The relationship between Clinical Etiological Anatomical Pathophysiological (CEAP) clinical class and cardiac Doppler parameters showed on that: In comparison with normal control, all cardiac Doppler parameters of C2 clinical class patients were basically unchanged, but the cardiac Doppler parameters of the C3 or higher CEAP class patients changed. Hence, we found a potential CEAP grade cut-off value (C3) linked to statistical changes in cardiac Doppler parameters.ConclusionCardiac Doppler parameters in patients with primary varicose veins could indeed be different from those of normal people, especially for C3 class or higher CEAP clinical class patients. Therefore, for those patients, pre-operative echocardiography can be used to evaluate cardiac hemodynamic changes, but large-scale clinical promotion requires further large sample studies.
The Corona Immunitas Digital Follow-Up eCohort to Monitor Impacts of the SARS-CoV-2 Pandemic in Switzerland: Study Protocol and First Results
Authors: Speierer Alexandre , Chocano-Bedoya Patricia O. , Anker Daniela , Schmid Alexia , Keidel Dirk , Vermes Thomas , Imboden Medea , Levati Sara , Franscella Giovanni , Corna Laurie , Amati Rebecca , Harju Erika , Luedi Chantal , Michel Gisela , Veys-Takeuchi Caroline , Zuppinger Claire , Nusslé Semira Gonseth , D’Acremont Valérie , Tall Ismaël , Salberg Éric , Baysson Hélène , Lorthe Elsa , Pennacchio Francesco , Frei Anja , Kaufmann Marco , Geigges Marco , West Erin Ashley , Schwab Nathalie , Cullati Stéphane , Chiolero Arnaud , Kahlert Christian , Stringhini Silvia , Vollrath Fabian , Probst-Hensch Nicole , Rodondi Nicolas , Puhan Milo A. , von Wyl Viktor 
Published: February 2022

Objectives: To describe the rationale, organization, and procedures of the Corona Immunitas Digital Follow-Up (CI-DFU) eCohort and to characterize participants at baseline.Methods: Participants of Corona Immunitas, a population-based nationwide SARS-CoV-2 seroprevalence study in Switzerland, were invited to join the CI-DFU eCohort in 11 study centres. Weekly online questonnaires cover health status changes, prevention measures adherence, and social impacts. Monthly questionnaires cover additional prevention adherence, contact tracing apps use, vaccination and vaccine hesitancy, and socio-economic changes.Results: We report data from the 5 centres that enrolled in the CI-DFU between June and October 2020 (covering Basel City/Land, Fribourg, Neuchâtel, Ticino, Zurich). As of February 2021, 4636 participants were enrolled and 85,693 weekly and 27,817 monthly questionnaires were collected. Design-based oversampling led to overrepresentation of individuals aged 65+ years. People with higher education and income were more likely to enroll and be retained.Conclusion: Broad enrolment and robust retention of participants enables scientifically sound monitoring of pandemic impacts, prevention, and vaccination progress. The CI-DFU eCohort demonstrates proof-of-principle for large-scale, federated eCohort study designs based on jointly agreed principles and transparent governance.
Targeted Venetoclax Therapy in t(11;14) Multiple Myeloma: Real World Data From Seven Hungarian Centers
Authors: Szita Virág Réka , Mikala Gábor , Kozma András , Fábián János , Hardi Apor , Alizadeh Hussain , Rajnics Péter , Rejtő László , Szendrei Tamás , Váróczy László , Nagy Zsolt , Illés Árpád , Vályi-Nagy István , Masszi Tamás , Varga Gergely 
Published: February 2022

Despite the introduction of novel agents, multiple myeloma remains incurable for most patients, necessitating further therapeutic options. Venetoclax, a selective BCL-2 inhibitor, had shown promising results in patients with translocation t(11;14), but questions remain open about its optimal use. We have contacted all Hungarian haematology centers for their experience treating t(11;14) myeloma patients with venetoclax. 58 patients were reported. 37 received venetoclax in the relapsed/refractory setting with few or no other therapeutic options available. 21 patients started venetoclax as salvage after failing to achieve satisfactory response to first line therapy. In the relapsed/refractory setting objective response rate (ORR) was 94%, median progression-free survival (PFS) 10.0 months and median overall survival (OS) 14.6 months. In reinduction patients, ORR was 100%, median PFS and OS were not reached. Importantly, we found no adverse effect of high risk features such as deletion 17p or renal failure, in fact renal failure ameliorated in 42% of the cases, including three patients who became dialysis independent. Our study also reports the highest number of plasma cell leukemia cases successfully treated with venetoclax published in literature, with refractory plasma cell leukemia patients achieving a median PFS of 10.0 and a median OS of 12.2 months.
Fungal and Bacterial Communities in Tuber melanosporum Plantations from Northern Spain
Authors: Herrero de Aza Celia , Armenteros Sergio , McDermott James , Mauceri Stefano , Olaizola Jaime , Hernández-Rodríguez María , Mediavilla Olaya 
Published: February 2022

Tuber melanosporum (Ascomycota, Pezizales) is an ectomycorrhizal fungus that produces highly appreciated hypogeous fruiting bodies called black truffles. The aim of this paper was to research the composition of ectomycorrhiza-associated fungal and bacterial communities in T. melanosporum oak plantations. Results of this paper showed the competitive effect of T. melanosporum on other fungal species, especially other mycorrhizal and pathogenic species. T. melanosporum was shown to be associated mainly with bacteria, some of them important for their properties as mycorrhizal helper bacteria. A dendrogram analysis of co-occurrence showed that T. melanosporum tended to co-occur with the following bacteria species: Singulisphaera limicola, Nannocistis excedens and Sporosarcina globispora. In addition, it was linked to fungal species such as Mortierella elongata, M. minutissima, Cryptococcus uzbekistanensis, C. chernovii and C. aerius. This study provides an exhaustive analysis of the diversity, structure and composition of fungal and bacterial communities associated with T. melanosporum to enhance understanding of the biology, composition and role of these communities in truffle plantations.
Mode-dependent dye absorption in phthalocyanine-doped acrylic optical fiber
Authors: Shigeyama Takahiro , Furukawa Rei 
Published: February 2022

Abstract
Phthalocyanine has attractive features as a dopant for plastic optical fibers. Its planar molecular structure and red absorption band are suitable for the design of fiber-optic strain sensors that use the dynamic orientation of dye induced by the deformation of the host matrix. The guidelines to achieve a phthalocyanine-doped fiber with a ruled dispersing manner were investigated. A synthesized fiber using phthalocyanine decorated with tertiary butyl groups showed mode-dependent absorption, which suggested gradual dye distribution in the core radial direction.
A Bragg reflection waveguide laser operating at an exceptional point
Authors: Peng Ruihong , Sun Shuning 
Published: February 2022

Abstract
A vertical Bragg reflection waveguide (BRW) laser is proposed and simulated for reaching single-mode output, which operates at an exceptional point (EP). We study the properties of the EP-BRW laser using both the transfer matrix method and the traveling wave model. The mode selection mechanism for the EP-BRW laser and the key design parameters for optimum performance are analyzed. The effect of the EP on laser performance is investigated to achieve high confinement transversely of the optical field and low threshold gain. At the EP, such laser system exhibits exotic behaviors, such as high transverse gain, high single-mode stability, and high slope efficiency.
PENGARUH PENDIDIKAN DAN PELATIHAN KERJA TERHADAP KINERJA KARYAWAN PADA PT. BUMI MEKAR HIJAU (BMH) OGAN KOMERING ILIR PROPINSI SUMATERA SELATAN
Authors: Anita Yuli 
Published: February 2022

Pendidikan dan pelatihan ini merupakan upaya untuk mengembangkan kemampuan intelektual dan kepribadian karyawan. Oleh karena itu setiap organisasi atau perusahaan yang ingin berkembang, pendidikan dan pelatihan karyawannya harus memperoleh perhatian yang lebih besar sehingga dapat meningkatkan kinerja karyawannya Peneitian ini dilakukan pada PT.BUMI MEKAR HIJAU (BMK) Ogan Komering Ilir Propinsi Sumatera Selatan . Agar sampel yang diambil dapat dikatakan representatif, maka penentuan besarnya sampel ini didasarkan pada uraian Arikunto (2002:112) “Apabila subyeknya kurang dari 100, lebih baik diambil semua sehingga penelitiannya merupakan penelitian populasi. Selanjutnya jika subyeknya besar (lebih dari 100) dapat diambil antara 10 – 15% atau 20 – 25% atau lebih. Sehingga berdasarkan uraian Arikunto (2002:112 ) jumlah sampel yang dibutuhkan dalam penelitian ini adalah: 180 X 25% = 45 karyawan. Oleh sebab itu hanya 45 lembar kuesioner yang valid untuk dianalisa. Hasil yang didapat dari analisis regresi dengan mengunakan alat SPSS versi 15 menunjukkan bahwa ada pengaruh dari pendidikan dan latihan terhadap kinerja karyawan pada PT. BUMI MEKAR HIJAU (BMK) Ogan Komering Ilir Propinsi Sumatera Selatan
PENGARUH GAYA KEPEMIMPINAN DAN KOMITMEN ORGANISASI TERHADAP KINERJA SATUAN KOMANDO RESOR MILITER 044 GARUDA DEMPO PALEMBANG
Authors: Rahayu Endang 
Published: February 2022

Penelitian ini menguji Pengaruh Gaya Kepemimpinan dan Komitmen Organisasi Terhadap Kinerja Satuan Komando Resor Militer 044 Garuda Dempo Palembang. tujuan penelitian adalah untuk mengetahui gaya kepemimpinan dan komitmen organisasi berpengaruh secara Parsial. Dan mengetahui gaya kepemimpinan dan komitmen organisasi berpengaruh secara Simultan. Penelitian ini menggunakan Koefisien Diterminan (R2) dan Uji T (secara parsial )
Dari hasil analisis maka hasil analisis tersebut yaitu berdasarkan pengujian secara serempak/simultan (Uji F), ternyata hasil penelitian membuktikan bahwa semua variabel dari Gaya Kepemimpinan dan Komitmen Organisasi secara simultan mempunyai pengaruh yang signifikan terhadap variabel dependen, yaitu Kinerja Anggota Satuan Komando Resor militer 044 Garuda Dempo Palembang. Hal ini berarti mendukung hipotesis yang diajukan. Secara parsial (Uji t) dapat disimpulkan bahwa Gaya Kepemimpinan (X1) dan Komitmen Organisasi (X2) memiliki pengaruh yang positif dan signifikan terhadap variabel Kinerja Anggota Satuan Komando Resor militer 044 Garuda Dempo Palembang. Dan kesimpulan lain yang bisa diambil dari data uji t adalah variabel komitmen organisasi memiliki pengaruh yang paling dominan terhadap variabel Anggota Satuan Komando Resor militer 044 Garuda Dempo Palembang. Hal ini berarti hipotesis yang menyatakan bahwa diduga variabel komitmen organisasi memiliki pengaruh yang paling dominan terhadap variabel kinerja Anggota Satuan Komando Resor militer 044 Garuda Dempo Palembang Anggota Satuan Komando Resor militer 044 Garuda Dempo Palembang itu ditolak. Diketahui bahwa nilai Adjusted R Square pada penelitian ini adalah 0,435. Hal ini berarti seluruh variabel bebas yakni gaya kepemimpinan (X1) dan komitmen organisasi (X2), mempunyai kontribusi secara bersama-sama sebesar 43,5% terhadap variabel kinerja Anggota Satuan Komando Resor militer 044 Garuda Dempo Palembang (Y), sedangkan sisanya sebesar 56,5% dipengaruhi oleh faktor-faktor lainnya yang tidak masuk dalam penelitian.
PENGARUH GAYA KEPEMIMPINAN TERHADAP KINERJA PEGAWAI DI KANTOR BASARNAS DI SUMATRA SELATAN
Authors: Rasjid Abdullah 
Published: February 2022

Penelitian ini menguji pengaruh gaya kepemimpinan terhadap kinerja pegawai di Kantor Basarnas Propinsi Sumatera Selatan.. Tujuan dari penelitian ini adalah . Untuk mengetahui dan mengalisis gaya kepemimpinan yang di gunakan di Basarnas. Metode penelitian ini menggunakan analisa kuantitatif yang membahas ada tidaknya pengaruh antara variabel bebas dan variabel terikat, dalam hal ini variabel bebas (x) adalah gaya kepemimpinan dan variabel tidak bebas (y) adalah kinerja pegawai.
Pada hasil R square (R2) menunjukkan didapat nilai sebesar 0,013 artinya persentase sumbangan gaya kepemimpinan terhadap kinerja pegawai 1,3% sedangkan sisa sebesar 98,7% dipengaruhi oleh variabel lain yang tidak dimasukkan dalam model ini. Pada variabel gaya kepemimpinan (X) diperoleh nilai t hitung sebesar 1-195 sedangkan nilai t tabel sebesar 1.645 karena t hitung (-1.945 karena t hitung ( -1.945) > ttabel (1.645), berdasarkan uji hipotesis bahwa gaya kepemimpinan sangat berpengaruh terhadap kinerja pegawai.
Hasil yang didapat dari analisis regresi dengan mengunakan alat SPSS versi 15 menunjukkan bahwa ada pengaruh dari Gaya Kepemimpinan terhadap kinerja karyawan di Kantor Basarnas Propinsi Sumatera Selatan.
PENGARUH PENGEMBANGAN KARIR TERHADAP MOTIVASI KERJA KARYAWAN PT. BANK BUKOPIN, TBK CABANG PALEMBANG
Authors: . Haikal 
Published: February 2022

Tujuan penelitian ini adalah untuk mengetahui Pengaruh Pengembangan Karir terhadap Motivasi Kerja Karyawan PT. Bank Bukopin Tbk. Dalam penelitian ini yang dimaksud adalah semua karyawan yang ada di PT. Bank Bukopin Tbk. Cabang Palembang berjumlah 115 orang, namun yang diambil sebagian sampel hanya 53 orang dengan metode simple random sampling.
Dari hasil pengolahan data diperoleh persamaan regresi linear sederhana y = 0,664 + 0,804 X dengan nilai koefisien determinasi sebesar 0,341, ini menunjukkan bahwa besarnya pengaruh pengembangan karir terhadap motivasi kerja karyawan PT. Bank Bukopin Tbk. Cabang Palembang adalah sebesar 34,1%, sedangkan dari hasil perhitungan nilai koefisien korelasi diperoleh sebesar 0,561. Ini berarti mempunyai hubungan yang sangat kuat antara pengembangan karir dan motivasi kerja karyawan PT. Bank Bukopin Tbk. Cabang Palembang. Juga didapat nilai thitung sebesar 4,83 dan ttabel sebesar 2,01 yang hasilnya nilai thitung > ttabel. Hal ini berarti H0 ditolak sehingga dapat disimpulkan bahwa pengembangan karir memiliki pengaruh signifikan terhadap motivasi kerja karyawan PT. Bank Bukopin Tbk. Cabang Palembang.
PENGARUH BUDAYA ORGANISASI DAN LINGKUNGAN KERJA TERHADAP KINERJA PEGAWAI PDAM TIRTA MUSI UNIT SEBERANG ULU 2 PALEMBANG
Authors: . Martini 
Published: February 2022

Penelitian ini bertujuan untuk mengetahui pengaruh budaya organisas dan lingkungan kerja terhadap kinerja karyawan PDAM Tirta Musi Unit Seberang Ulu 2 Palembang. Jenis penelitian ini adalah penelitian asosiatif kausal. Model analisis yang digunakan yaitu Analisis Regresi Linear Berganda. Sampel dalam penelitian ini adalah 36 responden yang merupakan kinerja karyawan PDAM Tirta Musi Unit Seberang Ulu 2 Palembang.
Permasalahan dalam penelitian ini adalah “ apakah dan berpengaruh secara parsial dan simultan terhadap kinerja?” Pengujian hipotesis menggunakan analisis regresi linear berganda, melalui uji T dan uji F, dengan maksud untuk mengetahui pengaruh variabel independen terhadap variabel dependent pada tingkat kepercayaan 95 % (a = 0,05).
Hasil penguji pada uji T pada variabel budaya organisasi berpengaruh positif terhadap kinerja, hal terlihat dari nilai t hitung (3,318) > t tabel (2,035), signifikansi (0,00) di bawah atau lebih kecil dari 0,05, sedangkan pada variabel lingkungan kerja berpengaruh positif terhadap kinerja, hal terlihat dari nilai t hitung (4,167) > t tabel (2,035) dan signifikansi (0,00) di bawah atau lebih kecil dari 0, 05. Pada pengujian pada uji F pada variabel budaya organisasi dan lingkungan kerja berpengaruh positif terhadap kinerja, hal terlihat dari nilai F hitung (14,694) > F tabel (3,285), dan signifikansi (0,01) di bawah atau lebih kecil dari 0, 05.
ETHICAL LEADERSHIP AT WORK AND WORKPLACE WELL-BEING OF EMPLOYEES IN A COAL POWER PLANT
Authors: Diosdado A. Ugmares  , Victoria O. Ligan  , Alberto N. Bandiola  
Published: February 2022

This study proposed that ethical leadership at work and workplace well-being are significantly related and that ethical leadership could also significantly influence workplace well-being. There was a total of 122 samples in this study, which included the rank and file workers and employees in a coal power plant, with the exclusion of the top management. The data were analyzed using descriptive and inferential statistics such as the mean and standard deviation, Pearson r, and multiple regression analysis. Results yielded high levels of ethical leadership at work and workplace well-being. Also, the correlation test revealed a significant relationship between the two variables in this study. In addition, the regression analysis revealed a significant influence of ethical leadership on workplace well-being. Finally, the regression models revealed that people-orientation is the best predictor for workplace well-being. The paper offers further discussion of the results.
KEYWORDS:	ethical leadership at work, workplace well-being, coal power plant, public administration,Philippines
Guidelines for Nanopharmaceutical Products for Regulatory Approval
Authors: Medhi Bikash 
Published: February 2022

The word 'nano' refers to a Greek prefix that means 'dwarf' or very little,' and represents a thousand millionth of a meter (10-9) in length. Nanoscience and nanotechnology are the study and application of nanoscale range materials. Initially, the term Nanotechnology was used by N. Taniguchi in 1974 at an international conference on industrial production in Tokyo to characterize the super-thin processing of materials with nanometre accuracy and the fabrication of nano-sized systems (Bayda S. et al., 2020). The usage of nanomaterials has enhanced the application of nanomedicine in various therapeutics area with challenges and limitations over the last ten years. Alteration of the physiochemical, biological, mechanical & other properties of the materials made the nanomaterials and it can be utilized in different useful activities such as drug development, drug target. Nanotechnology utilized novel nanomaterials to make useful products. This technology has been used to overcome the limitations & challenges in different drug therapies. (Harea JI et al., 2017).
The combination of nanotechnology with pharmaceuticals and biomedicals is termed nano pharmaceutical. Nanopharmaceuticals is a new technology in current practice. As a result, there are no widely agreed nanopharmaceuticals guidelines. The general idea of regulatory requirements for Active Pharmaceutical Ingredients (API), as stated in the CDSCO's New Drugs and Clinical Trial Rules 2019, was mandatory in drug development pathways. These criteria are also in line with the International Council for Harmonization (ICH) recommendations and international standards that other countries using such items follow. New Drugs and Clinical Trials Rules, 2019 should be followed in different drug development. (Harea JI et al., 2017).
Globally, there are important guidelines developed by the United States Food & Drugs Administration (USFDA), International Council for Harmonization (ICH), or Organization for Economic Co-operation and Development (OECD). (Harea JI et al., 2017).
Current regulatory approaches by US Food & Drug Administration (FDA), established the nanotechnology task force in August 2006. This regulatory approach encourages the development of nanoproducts. FDA has issued the guidelines in 2007 to the industry to address the benefits & risks of Drugs, medical devices, and other nanoproducts. FDA is also working with other U.S. government agencies to focus on the safety & efficacy of nanoproducts and U.S. initiates the National Nanotechnology Initiative (NNI) which is a federal research & development program to coordinate the effort of all government agencies involved in nanotechnology. The main goal of the NNI is to maintain the class of research & development program, encourage inducing the new technologies in the product, developing the supporting infrastructure & tools needed for nanotechnology (Ventola et al., 2012).
Green Synthesis and Evaluation of Zinc Oxide Nanoparticles from Manilkara Zapota Leaf Extract
Authors: Maseera Rahath , Sultana Ayesha , K Venu Madhav , M. Kiranmai 
Published: February 2022

Background: Zinc oxide Nanoparticles can be prepared by various chemical, physical, and biological methodologies. But biological approach is easier than the other methods and also eco-friendly.
Purpose of study: Plant-mediated amalgamation of Zinc oxide nanoparticles is promising contrast to traditional method of physical and chemical synthesis.
Method: In the current research work, Zinc oxide nanoparticles are synthesized by using Leaf extracts of Manilkara Zapota plant. Green synthesis was done utilizing the aqueous solution of Manilkara Zapota leaf extract as reducing agent and Zinc acetate salts along with Sodium hydroxide. Morphological, Structural and Antimicrobial properties of synthesized Zinc oxide nanoparticles were characterized using Scanning electron microscope, Fourier transform infrared analysis, Differential scanning calorimetry and Disc diffusion method. '
Results: Biologically synthesized nanoparticles of Manilkara Zapota leaf extract revealed significant Anti-bacterial and Anti-fungal activities.
Cocnclusion: The organically incorporated nanoparticles by Manilkara Zapota can be utilized as antimicrobial agent against various pathogenic organisms.
Potential Galactogogues: A Review
Authors: Sahu Umakant , Shah Kamal , Chauhan Nagendra Singh 
Published: February 2022

Worldwide many infants die every year due to malnutrition or disease. WHO advises breastfeeding as it is an inexpensive and effective form of feeding for saving life of infant’s health. Insufficient milk production in lactating mother is one of the main causes of death and malnutrition in infants. Main cause of milk deficiency is mother or child illness, preterm birth, mother-baby separation, lactation after long gape, anxiety, fatigue emotional stress, busy schedules, unhealthy life style of women’s and hormonal imbalance. This review aims to summarize that insufficiency of lactation should be treated in appropriate manner; there are substantial numbers of herbal drugs which are used to augment milk production in lactating mother. Alcoholic/Aqueous extract of different lactogenic drugs maintain or increase the lactation by different physiological changes in biological level. The systematic search for Herbal Medicine used as lactation considering all the articles published until 2021 through three scientific databases.