bluuebunny/crossref_metadata_2025_split huggingface dataset:
The effect of the Progressive Goal Attainment Program on cognitions, perceptions, and work participation of workers with chronic health problems: study protocol for a randomized controlled trial
Authors: de Wit Mariska , Zijlstra Hendrika P. , Hulshof Carel T. J. , van der Burg-Vermeulen Sylvia J. , de Boer Angela G. E. M. 
Published: September 2022

Abstract
Background
Cognitions and perceptions of workers with chronic health problems, such as catastrophizing thoughts and fear-avoidance beliefs, can negatively influence work participation. The Progressive Goal Attainment Program (PGAP) is an intervention developed in Canada with the aim of decreasing limiting cognitions and perceptions and increasing work participation. The objective of this protocol article is to describe the design of a randomized controlled superiority trial to study whether PGAP is effective in decreasing limiting cognitions and perceptions and increasing workability and work participation of workers with chronic health problems in the Netherlands.

Methods
This study is a randomized controlled superiority trial with two (parallel) groups, in which workers on sick leave are randomly assigned to an intervention group (PGAP intervention) or to a waiting-list control group (care as usual). The PGAP intervention consists of a maximum of 10 weekly individual sessions provided by a trained PGAP professional in which the worker learns about staying active, planning activities, and setting goals. Participants in this risk-targeted behavioral activation intervention also learn to be more aware of their cognitions and perceptions and learn about solution-focused problem-solving skills in challenging situations. The primary outcome is the degree of catastrophizing. Secondary outcomes are other personal cognitions and perceptions (e.g., expectations regarding return to work, self-efficacy), health symptoms (e.g., fatigue, depression), work participation (e.g., sick leave status, work hours), and other work-related outcomes (e.g., workability, quality of working life).

Discussion
Although PGAP shows positive effects in Canada, we do not know whether this intervention is effective in the Netherlands. This study is the first randomized controlled trial to test the effect of PGAP on limiting cognitions and perceptions and on work participation of workers with chronic health problems in the Netherlands. If PGAP is effective it could be implemented in the Netherlands in order to stimulate workability and work participation of workers.

Trial registration
The protocol of this study is registered in the Netherlands Trial Register (NL9832) in October 2021.
Reshaping the path of mild cognitive impairment by refining exercise prescription: a study protocol of a randomized controlled trial to understand the “what,” “for whom,” and “how” of exercise to promote cognitive function
Authors: Barha Cindy K. , Falck Ryan S. , Best John R. , Nagamatsu Lindsay S. , Hsiung Ging-Yuek Robin , Sheel A. William , Hsu Chun Liang , Kramer Arthur F. , Voss Michelle W. , Erickson Kirk I. , Davis Jennifer C. , Shoemaker J. Kevin , Boyd Lara , Crockett Rachel A. , ten Brinke Lisanne , Bherer Louis , Singer Joel , Galea Liisa A. M. , Jacova Claudia , Bullock Alexis , Grant Sofia , Liu-Ambrose Teresa 
Published: September 2022

Abstract
Background
Targeted exercise training is a promising strategy for promoting cognitive function and preventing dementia in older age. Despite the utility of exercise as an intervention, variation still exists in exercise-induced cognitive gains and questions remain regarding the type of training (i.e., what), as well as moderators (i.e., for whom) and mechanisms (i.e., how) of benefit. Both aerobic training (AT) and resistance training (RT) enhance cognitive function in older adults without cognitive impairment; however, the vast majority of trials have focused exclusively on AT. Thus, more research is needed on RT, as well as on the combination of AT and RT, in older adults with mild cognitive impairment (MCI), a prodromal stage of dementia. Therefore, we aim to conduct a 6-month, 2 × 2 factorial randomized controlled trial in older adults with MCI to assess the individual effects of AT and RT, and the combined effect of AT and RT on cognitive function and to determine the possible underlying biological mechanisms.

Methods
Two hundred and sixteen community-dwelling adults, aged 65 to 85 years, with MCI from metropolitan Vancouver will be recruited to participate in this study. Randomization will be stratified by biological sex and participants will be randomly allocated to one of the four experimental groups: (1) 4×/week balance and tone (BAT; i.e., active control); (2) combined 2×/week AT + 2×/week RT; (3) 2×/week AT + 2×/week BAT; or (4) 2×/week RT + 2×/week BAT. The primary outcome is cognitive function as measured by the Alzheimer’s Disease Assessment Scale-Cognitive-Plus. Secondary outcomes include cognitive function, health-related quality of life, physical function, actigraphy measures, questionnaires, and falls. Outcomes will be measured at baseline, 6 months (i.e., trial completion), and 18 months (i.e., 12-month follow-up).

Discussion
Establishing the efficacy of different types and combinations of exercise training to minimize cognitive decline will advance our ability to prescribe exercise as “medicine” to treat MCI and delay the onset and progression of dementia. This trial is extremely timely as cognitive impairment and dementia pose a growing threat to global public health.

Trial registration
ClinicalTrials.gov NCT02737878. Registered on April 14, 2016.
The unique diagnostic and management challenge of a patient with concomitant anti-interferon-gamma autoantibody associated immunodeficiency syndrome, IgG4-related disease, and treatment refractory, disseminated mycobacterium avium complex infection
Authors: Boyle Spencer , Hagiya Ashley , Nguyen Minh-Vu H. , Liebman Howard , Lee Jin Sol G. 
Published: September 2022

Abstract
Background
Anti-interferon-gamma autoantibody-associated immunodeficiency syndrome is a rare and underrecognized adult onset immunodeficiency syndrome associated with severe opportunistic infections such as disseminated nontuberculous mycobacterium. Few cases have documented a relationship with IgG4-related disease. Concomitant diagnoses of these diseases present a diagnostic and management challenge.

Case presentation
A 61 year old man of Southeast Asian descent with pulmonary mycobacterium avium complex infection presented to our hospital system with a new skin rash and worsening lymphadenopathy. He was eventually diagnosed with IgG4-related disease through excisional nodal biopsy. He was managed with immunosuppressive treatment with prednisone, rituximab and cyclophosphamide. He later re-presented with disseminated mycobacterium avium complex infiltration of his joints, bones and prostate. Original titers of anti-interferon-gamma autoantibodies were falsely negative due to being on immunosuppressive therapy for his IgG4-related disease. However, anti-interferon-gamma autoantibody titers were re-sent after immunosuppression was held and returned strongly positive.

Conclusions
This case reviews diagnostic criteria and discusses management strategies with existing challenges in treating a patient with concomitant adult onset immunodeficiency syndrome, IgG4-related disease and a disseminated mycobacterial avium complex infection.
Item performance across native language groups on the Iranian National University Entrance English Exam: a nationwide study
Authors: Bormanaki Hamidreza Babaee , Ajideh Parviz 
Published: September 2022

AbstractThis paper reports on an investigation of differential item functioning (DIF) in the Iranian Undergraduate University Entrance Special English Exam (IUUESEE) across four native language groups including the Azeri, the Persian, the Kurdish, and the Luri test takers via Rasch analysis. A total sample of 14,172 participants was selected for the study. After establishing the unidimensionality and local independence of the data, the authors employed two methods to test for the DIF: (a) a t-test uniform DIF analysis, which showed that the Luri test-takers were more favored than other native language groups, and (b) nonuniform DIF analysis, which revealed that majority of nonuniform DIF instances functioned in favor of the low-ability Azeri, the low-ability Persian, the high-ability Kurdish, and the high-ability Luri test-takers. A possible explanation for native language-ability DIF was that the Luri and low-ability test-takers were more likely to venture lucky guesses. We also referred to socioeconomic status (e.g., test-wiseness), guessing, overconfidence, thoughtless errors, stem length, time, L1, and unappealing distractors as possible sources of DIF in IUUESEE.
Difference between 5A score and the HOPE score
Authors: Okada Yohei , Matsuyama Tasuku , Hayashida Kei , Takauji Shuhei , Kanda Jun , Yokobori Shoji 
Published: September 2022

AbstractRecently, a letter to the editor was published to comment on the 5A score which is the prediction model for accidental hypothermia patients comparing the HOPE score. In this letter, we responded to the comments to clarify the difference between the 5A score and the HOPE score.
An online survey of dietary quality during complementary feeding; associations with maternal feeding self-efficacy and adherence to dietary recommendations
Authors: Spyreli Eleni , McKinley Michelle C. , Dean Moira 
Published: September 2022

Abstract
Background
Parents are the gatekeepers of nutrition in early life and their feeding practices form children’s dietary behaviours. Although maternal characteristics have been associated with certain feeding practices, their relationship with overall quality of complementary feeding diets has not been explored. This study aimed to: assess dietary quality in complementary feeding age; explore its association with maternal and child characteristics; and evaluate the association between complementary feeding practices and child weight.

Methods
An online cross-sectional survey captured data from a self-selected sample of mothers living in the UK with a healthy full-term child in complementary feeding age. A total of 466 mothers completed a questionnaire on their complementary feeding practices, demographics, anthropometrics, rates of maternal food neophobia, feeding self-efficacy, social support, postnatal depression and infant temperament. Dietary quality was assessed using the Complementary Feeding Utility Index (CFUI). Children were classified into underweight, normal weight, overweight and obese.

Results
Majority of participants reported high levels of dietary quality as determined by a mean CFUI score of 80%. High dietary quality was associated with reliance on the NHS recommendation on timing of complementary feeding and maternal self-efficacy in promoting a healthy diet and limiting non-recommended foods. Responsive feeding, longer breastfeeding duration, frequent exposure to fruits and to a high variety of protein-rich animal foods were significantly associated with lighter child weight status. Consumption of sweetened drinks and delayed introduction of lumpy foods were associated with heavier child weight status.

Conclusions
This study provided an evaluation of dietary quality in complementary feeding in a UK sample of children and explored its relationship with maternal and child attributes. Increasing understanding of the current complementary feeding recommendations and strengthening maternal feeding self-efficacy may be key for healthcare professionals and researchers to improving complementary feeding practices.
Adapting an intervention of brief problem-solving therapy to improve the health of women with antenatal depressive symptoms in primary healthcare in rural Ethiopia
Authors: Bitew Tesera , Keynejad Roxanne , Myers Bronwyn , Honikman Simone , Sorsdahl Katherine , Hanlon Charlotte 
Published: September 2022

Abstract
Background
Evidence-based brief psychological interventions are safe and effective for the treatment of antenatal depressive symptoms. However, the adaptation of such interventions for low- and middle-income countries has not been prioritised. This study aimed to select and adapt a brief psychological intervention for women with antenatal depressive symptoms attending primary healthcare (PHC) in rural Ethiopia.

Methods
We employed the Medical Research Council (MRC) framework for the development and evaluation of complex interventions. Alongside this, we used the ADAPT-ITT model of process adaptation and the ecological validity model (EVM) to guide content adaptation. We conducted formative work, comprising a qualitative study, a series of three participatory theories of change workshops and an expert adaptation workshop to assess the needs of the target population and to select an intervention for adaptation. The adaptation process followed a series of steps: (1) training Ethiopian mental health experts in the original South African problem-solving therapy (PST version 0.0) and an initial adaptation workshop leading to PST Version 1.0. (2) Version 1.0 was presented to perinatal women and healthcare professionals in the form of a ‘theatre test’, leading to further adaptations (version 2.0). (3) Local and international stakeholders reviewed version 2.0, leading to version 3.0, which was used to train 12 PHC staff using clinical cases. (4) Finally, feedback about PST version 3.0 and its delivery was obtained from PHC staff.

Results
In the first step, we modified case examples and terminology from the South African model, introduced an in-session pictorial flipchart for this low literacy setting, and added strategies to facilitate women’s engagement before translating into Amharic. In the second step, adaptations included renaming of the types of problems and inclusion of more exercises to demonstrate proposed coping strategies. In the third step, the components of motivational interviewing were dropped due to cultural incongruence. In the final step, refresher training was delivered as well as additional training on supporting control of women’s emotions to address PHC staff training needs, leading to the final version (version 4.0).

Conclusion
Using a series of steps, we have adapted the content and delivery of brief PST to fit the cultural context of this setting. The next step will be to assess the feasibility and acceptability of the intervention and its delivery in antenatal care settings.
Inhospital cardiac arrest — the crucial first 5 min: a simulation study
Authors: Stærk Mathilde , Lauridsen Kasper G. , Støtt Camilla Thomsen , Riis Dung Nguyen , Løfgren Bo , Krogh Kristian 
Published: September 2022

Abstract
Background
Early recognition and call for help, fast initiation of chest compressions, and early defibrillation are key elements to improve survival after cardiac arrest but are often not achieved. We aimed to investigate what occurs during the initial treatment of unannounced in situ simulated inhospital cardiac arrests and reasons for successful or inadequate initial resuscitation efforts.

Methods
We conducted unannounced full-scale in situ simulated inhospital cardiac arrest followed by a debriefing. Simulations and debriefings were video recorded for subsequent analysis. We analyzed quantitative data on actions performed and time measurements to key actions from simulations and qualitative data from transcribed debriefings.

Results
We conducted 36 simulations. Time to diagnosis of cardiac arrest was 37 (27; 55) s. Time to first chest compression from diagnosis of cardiac arrest was 37 (18; 74) s, time to calling the cardiac arrest team was 144 (71; 180) s, and time to first shock was 221 (181; 301) s. We observed participants perform several actions after diagnosing the cardiac arrest and before initiating chest compressions. Domains emerging from the debriefings were teaming and resources. Teaming included the themes communication, role allocation, leadership, and shared knowledge, which all included facilitators and barriers. Resources included the themes knowledge, technical issues, and organizational resources, of which all included barriers, and knowledge also included facilitators.

Conclusion
Using unannounced in situ simulated cardiac arrests, we found that key elements such as chest compressions, calling the cardiac arrest team, and defibrillation were delayed. Perceived barriers to resuscitation performance were leadership and teaming, whereas experience, clear leadership, and recent training were perceived as important facilitators for treatment progress.
The association between cannabis and codeine use: a nationally representative cross-sectional study in Canada
Authors: Garg Ria , Shojania Kam , De Vera Mary A. 
Published: September 2022

Abstract
Background
Due to the growing use of cannabis for the purposes of pain relief, evidence is needed on the impact of cannabis use on concurrent analgesic use. Therefore, our objective was to evaluate the association between the use of cannabis and codeine.

Methods
We conducted a cross-sectional study using data from the nationally representative Canadian Tobacco, Alcohol and Drugs Survey (2017). The primary explanatory variable was self-reported use of cannabis within the past year. The outcome was the use of codeine-containing product(s) within the past year. We used multivariable binomial logistic regression models.

Results
Our study sample comprised 15,459 respondents including 3338 individuals who reported cannabis use within the past year of whom 955 (36.2%) used it for medical purposes. Among individuals who reported cannabis use, the majority were male (N = 1833, 62.2%). Self-reported use of cannabis was associated with codeine use (adjusted odds ratio [aOR] 1.89, 95% CI 1.36 to 2.62). Additionally, when limited to cannabis users only, we found people who used cannabis for medical purposes to be three times more likely to also report codeine use (adjusted odds ratio [aOR] 2.96, 95% CI 1.72 to 5.09).

Discussion
The use of cannabis was associated with increased odds of codeine use, especially among individuals who used it for medical purposes. Our findings suggest a potential role for healthcare providers to be aware of or monitor patients’ use of cannabis, as the long-term adverse events associated with concurrent cannabis and opioid use remain unknown.
Exosomes in schizophrenia: Pathophysiological mechanisms, biomarkers, and therapeutic targets
Authors: Wang Yu , Amdanee Nousayhah , Zhang Xiangrong 
Published: September 2022

Abstract
While schizophrenia (SCZ) is a devastating psychiatric disorder that detrimentally affects a significant portion of the worldwide population, its diagnosis is traditionally based on a relatively subjective assessment of current symptoms and medical history, devoid of an objective diagnostic modality. Antipsychotic medications are commonly used in the treatment of SCZ; however, some patients have low remission rates or forsake treatment due to the associated multiple side effects, resulting in recurrent episodes of the disease and poor prognosis. These situations imply that the diagnosis, treatment, and prognosis of SCZ need to be improved to increase the odds of a better outcome. Mounting studies have found that extracellular vesicles (EVs) play essential roles in the central nervous system. They are implicated in several mechanisms closely associated with SCZ such as cellular communication and synaptic plasticity. They can additionally exhibit neuroprotective and therapeutic effects. Since they possess distinct constituents, are readily available, easily detectable, and dependent on the internal environment, they can potentially serve as reliable biomarkers for disease diagnosis. Moreover, their biological configuration along with their ability to increase the bioavailability of their constituents and modulate intricate intracellular reactions in target cells, propel EVs as new targets for treatment. This review paper summarizes relevant research pertaining to the roles of EVs in SCZ, with the aim of improving insights into SCZ pathogenesis and evaluating EVs as potential biomarkers in the diagnosis and treatment of SCZ.
The Mughal Self and the Jain Other in Siddhicandra's Bhanucandraganicarita
Authors: Truschke Audrey 
Published: September 2022

Abstract
Siddhicandra's Bhanucandraganicarita (Biography of Bhanucandra, ca. 1620s) enacts a stunning development in Sanskrit historiography. The text's title bills it as a biography of a Jain mendicant, a standard genre of Jain-authored works. But, in fact, the text treats cross-cultural relations between Jain ascetics and Mughal elites as its main subject. It is arguably the first Sanskrit text to focus specifically and exclusively on Mughal contexts. This literary and historiographical choice is all the more noteworthy because of the text's carefully delineated approach to negotiating between Sanskrit, Jain, and Mughal cultural norms. Throughout the work Siddhicandra depicts the Mughals as steeped in Sanskrit literary culture while showing himself to be fluent in a Persianate cultural zone. In the tradition of Sanskrit writing on Indo-Persian political figures, which was several hundred years old by the early seventeenth century, the Bhanucandraganicarita marks a moment when the Mughals ceased to be other in any identifiable way, except as offering a new cultural context for Jain self-expression.
The Use of Brajbhasha in Sikh Contexts
Authors: Vig Julie 
Published: September 2022

Abstract
This article connects the Sikh tradition to wider cultural and literary worlds by examining how gurbilās literature—written from the end of the seventeenth century into the nineteenth—is tied to the wider Braj literary world and more specifically to Braj martial poetry. Gurbilās literature—or “the play or pastimes of the Guru”—refers to a collection of biographies of the Sikh Gurus emphasizing the narration of life stories of Guru Gobind Singh and his heroic deeds. This essay focuses on the portrayal of an important battle widely narrated in Sikh history, the battle of Bhangani (dated to 1688), in three gurbilās texts. Its goal is to examine two main issues: first, how these three narratives, and gurbilās literature more broadly, interact along multiple poles with the wider world of Braj literary traditions, specifically with Braj martial poetry; and second, how these texts provide us with material to think about the context of performance of these texts. It concludes with a broad reflection on how these three narratives represent a textual microcosm that reveals the many connections gurbilās literature—and more broadly the Sikh cultural world—has with other genres and traditions.
Demystifying the Image
Authors: Alemu Amsale 
Published: September 2022

AbstractWhile opposition to the Ethiopian monarchy was an immediate imperative of the Ethiopian revolutionary movement, self-professed “anti-feudalism” was but one part of the political-economic object of revolutionary critique. Originating from a country famous for its legacy of African independence, and against a monarch who was a global pan-African icon, Ethiopian revolutionary opposition to Haile Selassie would require not only a politics of dissent, but also an anti-colonial framing. This article centers anti-imperialism—specifically challenges to US neo-imperialism in Ethiopia—among Ethiopian student revolutionaries in the United States during the late 1960s and early 1970s. Examining organizational writing and direct action, as well as editorials in Muhammad Speaks and The Black Panther, this article argues that US-based Ethiopian students employed demystification as a signature revolutionary tactic. They attempted to reframe Ethiopian exceptionalist narratives as currency of US neo-imperialism, drawing on arguments strengthened by engaging Black Power concepts and thinkers. Demystification, while rooted in narrative modes and historical tropes specific to Ethiopian students' location in the United States, offers a concept to think through other oppositional movements as generative of global theoretical critique. Ethiopian students not only demanded the overthrow of the monarchy, but also joined anti-colonial appeals for the structural transformation of the world.