bluuebunny/crossref_metadata_2025_split huggingface dataset:
A novel prognostic model based on urea cycle-related gene signature for colorectal cancer
Authors: Guo Haiyang , Wang Yuanbiao , Gou Lei , Wang Xiaobo , Tang Yong , Wang Xianfei 
Published: October 2022

BackgroundColorectal cancer (CRC) is the second leading cause of cancer-related deaths in the world. This study aimed to develop a urea cycle (UC)-related gene signature that provides a theoretical foundation for the prognosis and treatment of patients with CRC.MethodsDifferentially expressed UC-related genes in CRC were confirmed using differential analysis and Venn diagrams. Univariate Cox and least absolute shrinkage and selection operator regression analyses were performed to identify UC-related prognostic genes. A UC-related signature was created and confirmed using distinct datasets. Independent prognostic predictors were authenticated using Cox analysis. The Cell-type Identification by Estimating Relative Subsets of RNA Transcripts algorithm and Spearman method were applied to probe the linkage between UC-related prognostic genes and tumor immune-infiltrating cells. The Human Protein Atlas database was used to determine the protein expression levels of prognostic genes in CRC and normal tissues. Verification of the expression levels of UC-related prognostic genes in clinical tissue samples was performed using real-time quantitative polymerase chain reaction (qPCR).ResultsA total of 49 DEUCRGs in CRC were mined. Eight prognostic genes (TIMP1, FABP4, MMP3, MMP1, CD177, CA2, S100P, and SPP1) were identified to construct a UC-related gene signature. The signature was then affirmed using an external validation set. The risk score was demonstrated to be a credible independent prognostic predictor using Cox regression analysis. Functional enrichment analysis revealed that focal adhesion, ECM-receptor interaction, IL-17 signaling pathway, and nitrogen metabolism were associated with the UC-related gene signature. Immune infiltration and correlation analyses revealed a significant correlation between UC-related prognostic genes and differential immune cells between the two risk subgroups. Finally, the qPCR results of clinical samples further confirmed the results of the public database.ConclusionTaken together, this study authenticated UC-related prognostic genes and developed a gene signature for the prognosis of CRC, which will be of great significance in the identification of prognostic molecular biomarkers, clinical prognosis prediction, and development of treatment strategies for patients with CRC.
Prognostic value and immunological role of BAIAP2L2 in liver hepatocellular carcinoma: A pan-cancer analysis
Authors: Han Xiudan , Long Wei , Liu Ying , Xu Jixiong 
Published: October 2022

BackgroundIn recent years, the role of BAI1-associated protein 2-like 2 (BAIAP2L2) in the prognosis and immune microenvironment of various cancers has attracted increasing attention. However, its clinical value and immune infiltration in liver hepatocellular carcinoma (LIHC) remain unclear.ObjectiveTo investigate the prognostic value of BAIAP2L2 and its correlation with immune infiltration in LIHC, we conducted corresponding data mining.MethodsIn this study, The Cancer Genome Atlas, GTEx, StarBase, UALCAN, TIMER, GEPIA, Human Protein Atlas, Kaplan–Meier Plotter, cBioPortal, LinkedOmics, STRING and BioGPS databases were used to analyze BAIAP2L2 in cancers. Logistic regression and Cox regression were performed to analyze the correlation between clinical features and BAIAP2L2 expression in LIHC. In addition, the diagnostic and prognostic values of BAIAP2L2 in LIHC were determined by receiver operating characteristic (ROC) curves and nomograms. Single-sample gene set enrichment analysis (ssGSEA), BioGPS and TIMER were used to analyze the correlation between BAIAP2L2 and immune infiltration. More importantly, quantitative real-time polymerase chain reaction was used to verify BAIAP2L2 expression in a liver cancer cell line and a normal cell line. Visualization of data was mostly achieved using R language, version 3.6.3.ResultsHigh BAIAP2L2 levels indicated poor overall survival (OS) and disease-free survival (DFS) of patients with LIHC. Abnormally increased expression of BAIAP2L2 in LIHC may be the result of both genetic alterations and lower DNA methylation levels. Furthermore, Cox regression analysis showed that high BAIAP2L2 expression was an independent risk factor for OS and DFS in patients with liver cancer. ROC curves and nomograms also confirmed the diagnostic and prognostic values of BAIAP2L2 in LIHC. Additionally, a PPI network of BAIAP2L2 was established and results implyed that BAIAP2L2 interacts with MTSS1, AMPH, FCHO1, SYT9, PDK2, MTSS1L, PM20D1, CHST4 and PALM3. ssGSEA showed that BAIAP2L2 was associated with T cells and natural killer cells. Simultaneously, the TIMER database showed that the expression of BAIAP2L2 in LIHC was positively correlated with tumor infiltrating cells, including B cells, CD8+ T cells, CD4+ T cells, macrophages, neutrophils and dendritic cells.ConclusionsThrough pan-cancer analysis, prognostic and immunological value of BAIAP2L2 in LIHC was identified. This is the first report on the potential of BAIAP2L2 as a prognostic biomarker and its correlation with immune infiltration in LIHC.
Case Report: Potential Predictive Value of MMR/MSI Status and PD-1 Expression in Immunotherapy for Urothelial Carcinoma
Authors: Ma Yu-Ting , Li Yan , Yan Li , Hua Fang , Wang Dong-Guan , Xu Guo-Ying , Yang Hong-Lan , Xue Ying-Jie , Qin Ye-Jun , Sha Dan , Ning Hao , Zhao Miao-Qing , Yao Zhi-Gang 
Published: October 2022

Immune checkpoint inhibitors (ICIs) have shown encouraging outcomes against Lynch syndrome (LS)-associated colorectal cancer (CRC) and endometrial cancer with mismatch repair deficient/microsatellite instability–high (dMMR/MSI-H). However, there is as yet no clarity on the safety and efficacy of immunotherapy combined with chemotherapy in LS-associated urothelial carcinoma (UC). Here, we report a patient with recurrent and metastatic LS-associated UC who achieved sustained response to programmed death protein 1 (PD-1) inhibitor combined with chemotherapy over 31 months, during which the side effects of immunotherapy could be controlled and managed. Our findings indicate that the dMMR/MSI status and PD-1 expression in UC may have potential predictive value for the response to PD-1-targeted immunotherapy. Our case supports the inclusion of such combination and/or monotherapy for UC in clinical studies and using dMMR/MSI status and PD-1 expression as potential predictive biomarkers for assessment of the therapeutic response.
Analysis of Internal Angle Error of UAV LiDAR Based on Rotating Mirror Scanning
Authors: Zhou Hao , Mao Qingzhou , Song Yufei , Wu Anlei , Hu Xueqing 
Published: October 2022

UAV LiDAR is a powerful tool for rapidly acquiring ground-based 3D spatial information and has been used in various applications. In addition to the ranging mechanism, the scanning method is also an important factor, affecting the performance of UAV LiDAR, and the internal angle error of LiDAR will seriously affect its measurement accuracy. Starting from the rotary scanning model of a single-sided mirror, this paper presents a comparative study of the characteristics of 45° single-sided mirror scanning, polygon prism scanning, polygon tower mirror scanning, and wedge mirror scanning. The error sources of the quadrangular tower mirror scanning are analyzed in detail, including the angle deviation between the direction of emitted laser and the rotation axis (typical 0.13 ± 0.18° and 0.85° ± 0.26°), the angle deviation between the mirror’s reflection plane and the rotation axis, and the surface angle deviation between multiple surfaces (typical ± 0.06°). As a result, the measurement deviation caused by the internal angle error can be as high as decimeter to meter, which cannot be fully compensated by simply adjusting the installation angle between the UAV and the LiDAR. After the calibration of the internal angle error, the standard deviation of the elevation difference between the point cloud and the control point is only 0.024 m in the flight experiment at 300 m altitude.
A Conceptual Framework for Integrating TPB With Context-Relevant Variables to Predict e-Learning Success During the Covid -19 Pandemic
Authors: Plata Lerma Diego Fernando , Afful-Dadzie Eric , Kwarteng Michael Adu , Nwaiwu Fortune , Ntsiful Alex 
Published: October 2022

The COVID-19 pandemic has necessitated the digitalization of some aspects of our lives including education. However, as we witness a phenomenal rise in the demand for online learning, the decision to migrate to online learning platforms is dependent on the learner’s preparedness to embrace it. The objective of this study is to conceptualize a framework that measures the tendency of learners to adopt online learning in an era characterised by so many disruptions. To do this, we adopt document analysis on databases such as SCOPUS, Web of Science, EBSCO and Google Scholar using Boolean search engines; AND, OR, NOT, *, (), ‘’’’, +, -, <,>. mainly on current scientific manuscripts through the use of the keywords “e-learning”, “theory of planned behaviour”, “Covid 19”, “distance learning”, “environmental factors” and “academic technology adoption”. Subsequently, we integrate the theory of planned behaviour with other context-relevant variables as the bases of the study, and conceptualise a framework to predict e-learning success in the covid-19 era. This study contributes to the scientific body of knowledge on e-learning, particularly from the perspective of a forced mass adoption of e-learning occasioned by a global pandemic.
Aprendizaje de las ciencias en preescolar: la construcción de representaciones y explicaciones sobre la luz y las sombras
Authors: Gallegos Cázares Leticia , Flores Camacho Fernando , Calderón Canales Elena 
Published: October 2022

En el presente trabajo se exponen las construcciones conceptuales que pueden hacer los estudiantes del preescolar sobre las nociones de luz y de sombras mediante la propuesta didáctica denominada Educación en Ciencias en Preescolar (educienpre), en la que se desarrollan secuencias didácticas y materiales, susceptibles de ser llevadas al aula en condiciones normales. Asimismo, se describen las características de la propuesta y se analizan dichas construcciones conceptuales en función de sus explicaciones y representaciones. Se efectúa una comparación con investigaciones previas sobre la formación de las sombras y se muestran las posibilidades de los niños del preescolar de alcanzar conceptualizaciones que, de forma natural, logran los de mayor edad.
El análisis que se presenta de las acciones de los preescolares en diversas situaciones físicas brinda elementos de mayor profundidad para comprender la construcción de representaciones y nociones científicas que pudieran verse reflejadas en una enseñanza de las ciencias más adecuada para los niños pequeños.
Percepciones iniciales de los estudiantes sobre la formación práctica
Authors: López López María del Carmen , Hinojosa Pareja Eva 
Published: October 2022

La relevancia conferida al prácticum en la formación inicial, y su importante contribución a la formación de profesionales competentes y cualificados le convierten en centro de interés prioritario en este proceso de cambio que experimenta la educación superior. El trabajo que mostramos centra su atención en las ideas y concepciones que tienen los estudiantes de la Licenciatura de Pedagogía sobre el prácticum antes de su realización, al tiempo que ofrece vías de participación, a través de grupos de discusión, desde las que los propios estudiantes pueden contribuir a la articulación y optimización de este periodo formativo.
El análisis de las percepciones iniciales que preceden el desarrollo de una experiencia formativa no sólo nos aproximan a las preconcepciones desde la que los estudiantes inician dicha formación práctica, sino que ayuda a esclarecer algunas de las claves que facilitan o dificultan el aprovechamiento óptimo que la experiencia misma ofrece, al tiempo que permite contrastar, en su segundo momento, la incidencia que la realización del prácticum tiene en la modificación de dichas concepciones previas. Por otra parte, implicar a los estudiantes en dinámicas discursivas relativas al prácticum, dificultades y posibilidades de mejora, antes de su realización, puede ayudar a incrementar la calidad del mismo (Ryan y otros, 1996), elevar su nivel de compromiso con la carrera, algo que según Carles y Prodan (2003) la realización del prácticum no acaba de conseguir, y responde a la propuesta –formulada por Zabalza (2006)– de facilitar un desarrollo competencial previo a la realización del prácticum.
La enseñanza y aprendizaje del Cálculo Integral desde la perspectiva del nuevo paradigma de la sociedad del conocimiento
Authors: Lois Alejandro Enrique , Milevicich Liliana María 
Published: October 2022

Atendiendo a la importancia del uso de tecnologías digitales en cuanto a su potencialidad de favorecer la transformación de los sistemas escolares, de brindar nuevos espacios y oportunidades para el aprendizaje y de favorecer la redefinición de roles, abordamos esta problemática en el contexto de la educación superior con una propuesta que supone un cambio en los modelos de enseñanza-aprendizaje, en las metodologías, en las formas e instrumentos de evaluación, en el papel del profesor y del estudiante.
Consideramos que una manera de integrar la tecnología y la ciencia es a través de la enseñanza y aprendizaje de ésta última utilizando las herramientas tecnológicas disponibles, y que el uso de las TIC en el aula constituye un recurso didáctico facilitador de los procesos de enseñanza aprendizaje. En ese sentido, el uso del ordenador puede ser un medio para coordinar los distintos registros de representación de un concepto, si bien la mayor contribución de las nuevas tecnologías a la mejora del aprendizaje, se centra en la creación de medios personalizados que mejor se adapten a los requerimientos pedagógicos de la propuesta.
En el contexto anteriormente descrito, diseñamos e iniciamos el desarrollo de un Proyecto con el propósito general de implementar una propuesta didáctica que prevea por una parte, la utilización de distintos sistemas de representación en el desarrollo de actividades individuales y grupales, y por la otra, que promueva la conjeturación, experimentación, formalización, demostración, síntesis, categorización, análisis retrospectivo, extrapolación y argumentación, con el auxilio del ordenador; y la retroalimentación temprana sobre tales producciones de los alumnos de tal manera que puedan reflexionar sobre los propios errores.
Regulação supranacional em educação na África: estudo a partir da política de formação de professores de Angola
Authors: Bortot Camila Maria , Brás Chocolate Adão , Scaff Elisângela Alves da Silva 
Published: October 2022

Este artigo tem como objetivo analisar as relações entre a regulação supranacional e a construção de políticas de formação de professores para o continente africano, focalizando a análise para o contexto angolano. A base metodológica da pesquisa é de caráter documental, organizada a partir de documentos constantes dos repositórios digitais de agências da Onu, do Banco Mundial e do governo angolano. Verifica-se assim que os parâmetros definidos para a formação de professores em Angola são fortemente influenciados pelas orientações e projetos de cooperação internacional, com foco na formação inicial de professores. Essa característica faz parte da agenda global de fomento à o ampliaçãoda quantidade de professores (as) na região por meio do investimento em programas destinados a esse fim. Nesse cenário Angola recebeu financiamento para vários projetos, entre eles o Programa Aprendizagem para Todos, formulado por meio de cooperação entre Banco Mundial e o Governo angolano. Sinaliza-se, assim, a tendência de vinculação da formação inicial e continuada de docentes ao sucesso educacional, configurando uma regulação supranacional direta e influente na agenda das políticas educacionais em Angola.
Implementation of Integrated Reporting <IR> Framework In Non-Profit Organizations
Authors: Nurhaliva Nurhaliva , Handajani Lilik , Sokarina Ayudia 
Published: October 2022

This study aims to implement the 2021 revision of IIRF in X non-profit organization. This research is qualitative research with an action research approach. The results of this study indicate that X non-profit organization is able to present <IR> based on the eight content elements of IIRF, although the information presented in <IR> is not fully presented in full because the adoption of directed <IR> in IIRF is still at an early stage. However, if the organization is consistent with presenting <IR>, there will be a gradual increase in the following years. This research is expected to provide additional guidance on how to apply IIRF as a guide for presenting <IR> for organization X and other non-profit organizations interested in implementing IIRF.
CHARACTERISTICS OF THE BRICK OF THE PRINCELY AGE IN THE PAPERS OF V. А. BOGUSEVYCH
Authors: Makhota O. О. 
Published: October 2022

Volodymyr Bogusevych researched various monuments of archeology, art and architecture of the IX—XVII centuries. He can be attributed to the constellation of scholars who laid the necessary vectors for studying the laws of architecture of the Princely Age. The methods of architectural and archeological research developed by V. Bogusevych still helps scholars to study the monuments of stone architecture.

Bogusevych made a significant contribution to the study of one of the main structural material of the palace and temple architecture — the plinth. Having started his academic path in this direction along with the most famous experts in plinth (M. Karger, P. Rappaport and M. Kholostenko), he developed his own method of dating bricks of the Princely Age. However, V. Bogusevych did not pay proper attention to the coverage of the signs by which he dated the plinth. Judging by the works of V. Bogusevych, most likely it was its size. Also there is a tendency in his works to date the bricks by presence of marks and end marks. He collected a large collection of branded plinths from Kyiv, Chernihiv, Ostra and Putivl and has repeatedly participated in discussions about the possible purpose of the signs.

Analyzing the works of V. Bogusevych, we can conclude that he developed his terminological and conceptual apparatus in the study of plinth gradually. It was not until the 1950s that in his papers the word «plinth» appeared next to the word «brick» to denote this type of building material. This was influenced by joint work with professional architects Yu. Aseev and M. Kholostenko. After all, it is in joint work with them that the use of these terms can be traced.
Of course, modern research methods have advanced significantly in the study of plinths and sometimes refute the conclusions of the scholar. But the source base of brick sizes and signs on it significantly influenced the development of modern methods of attribution of plinths and is an extremely valuable source for future generations of researchers of bricks of the Princely Age.
BEADS FROM THE OSTRIV BURIAL GROUND (ACCORDING TO MATERIALS EXCAVATED IN 2017—2020)
Authors: Diachenko D. G. 
Published: October 2022

The presence of elements of the necklace sets among the grave goods is one of the characteristic features of the Ostriv burial ground. They were found in 21 graves from 83 excavated in the period of 2017—2020.
In 19 cases they were part of the neck ornament. The necklace was an attribute of women’s costume in 17 burials, which is slightly less than half of the total number of women’s burials. This indicates both social differentiation within the group and differences in costume composition. Mainly the necklace was found among the grave goods of girls and young women.
In two cases one shell of Cypraea moneta was found in men’s burials indicating their use as buttons or talismans.
In total, 546 elements of the necklace set were found in the burials. Most of the finds (51 %) represented by glass products, slightly less (45 %) by shells (Cypraea moneta is absolutely dominated), 3.8 % is non-ferrous metal products, one detected bead (0.2 %) is made of faience.
The uneven distribution of elements in the necklace from one item to almost hundred is recorded. The number of beads of a certain type in the set could be large, even absolute, while others consisted of more different elements but could be inferior to the first one by total number of copies in the set.
Significant predominance of beads with metal foil, blue ribbed and Cypraea moneta shells. These varieties together make up 69 % of all identified elements of the necklace set and were the most popular and available for necklace formation among these people.
The marginality of other elements should indicate their secondary nature and addition to the main set if possible. However, in our opinion, in this case the situation is diametrically opposed. The most common types of elements — with metal foil and Cypraea moneta — have been obtained by the population in mass and added to existing vague sets or formed new ones.
ANALISIS FAKTOR-FAKTOR MOTIVASI TENAGA KESEHATAN TERHADAP KUALITAS PELAYANAN KESEHATAN DI PUSKESMAS TINAMBUNG KABUPATEN POLEWALI MANDAR PROVINSI SULAWESI
Authors: H Megawati , Firman Ahmad , Rahim Deddy Rahwandy 
Published: October 2022

Tujuan penelitian ini adalah untuk mengetahui dan menganalisis Kebutuhan: Prestasi, Kekuasaan, dan Afiliasi, terhadap Kualitas Pelayanan Kesehatan di Puskesmas Tinambung Kabupaten Polewali Mandar Provinsi Sulawesi Barat. Penelitian ini menggunakan pendekatan kuantitatif . Sumber data yang digunakan dalam penelitian adalah data primer, dengan teknik pegumpulan data berupa kuesioner dan studi kepustakaan. Sampel dalam penelitian ini adalah berjumlah 34 responden dengan menggunakan analisis regresi Linier Berganda. Proses pengolahan data menggunakan aplikasi sofware SPSS for Windows Versi 25. Hasil penelitian menunjukkan bahwa variabel kebutuhan: prestasi, kekuasaan dan afiliasi secara simultan berpengaruh signifikan terhadap kualitas pelayanan kesehatan yang dapat dilihat dari hasil uji F, dimana F hitung 17,548 > F tabel 2,91 sehingga pada taraf signifikan 0,000 < dari taraf signifikan 0,05 dan nilai R square sebesar 0,637. Secara parsial variabel kebutuhan prestasi tidak berpengaruh signifikan terhadap kualitas pelayanan kesehatan sebesar 0,175. Sedangkan variabel kebutuhan kekuasaan berpengaruh signifikan terhadap kualitas pelayanan kesehatan sebesar 0,014 dan variabel kebutuhan afiliasi berpengaruh signifikan terhadap kualitas pelayanan kesehatan sebesar 0,000.
ANALISIS FAKTOR-FAKTOR TERHADAP KINERJA PEGAWAI PADA KANTOR KECAMATAN ULUBONGKA KABUPATEN TOJA UNA-UNA
Authors: Arif Mohamad , Idris Muhammad , Alam Syamsul 
Published: October 2022

Penelitian ini bertujuan untuk menganalisis (1) Untuk mengetahui dan menganalisis motivasi intrinsik dan motivasi ekstrinsik berpengaruh secara parsial terhadap kinerja pegawai pada Kantor Kecamatan Ulubongka Kabupaten Tojo Una-Una; (2) Untuk mengetahui dan menganalisis motivasi intrinsik dan ekstrinsik berpengaruh secara simultan terhadap kinerja pegawai pada Kantor Kecamatan Ulubongka Kabupaten Tojo Una-Una; (3) Untuk mengetahui dan menganalisis manakah yang paling dominan terhadap kinerja pegawai pada Kantor Kecamatan Ulubongka Kabupaten Tojo Una-Una. Penelitian ini menggunakan metode kuantitatif bertujuan untuk menguji teori dengan kenyataan dilapangan melaui pengukuran pengaruh variabel independent terhadap variabel dependen. Sampel penelitian berjumlah 50 orang. Penelitian ini menggunakan sampel jenuh dan analisis regresi linier berganda.
Dari hasil analisis data dengan menggunakan SPSS 22 dapat diketahui bahwa Motivasi Intrinsik berpengaruh positif dan signifikan terhadap peningkatan kinerja pegawai. Motivasi ekstrinsik berpengaruh positif signifikan pada peningkatan kinerja pegawai. Perhitungan koefisien determinasinya (R2) diperoleh hasil 0,909 yang artinya bahwa variabel independen (X) sebesar 90,9%, sedangkan 9,1% variabel dependen (Y) dipengaruhi oleh variabel-variabel lain yang tidak diteliti.