bluuebunny/crossref_metadata_2025_split huggingface dataset:
KEPATUHAN DIET, STATUS GIZI DAN KUALITAS HIDUP PASIEN DIABETES MELITUS TIPE 2 DI POSBINDU PTM PUSKESMAS ULEE KARENG
Authors: Mardhatillah Ghina , Mamfaluti Teuku , Jamil Kurnia Fitri , Nauval Iflan , Husnah Husnah 
Published: October 2022

Latar Belakang : Penatalaksanaan diabetes sangat ditentukan oleh faktor kepatuhan diet dan status gizi. Tujuan : Mengetahui hubungan kepatuhan diet dan status gizi dengan kualitas hidup pasien DM tipe 2 di Posbindu PTM Puskesmas Ulee Kareng.Metode : Penelitian ini merupakan penelitian analitik observasional dengan desain cross sectional. Teknik pengambilan sampel yang digunakan adalah non-probability sampling dengan metode accidental sampling. Penelitian dilakukan dari tanggal 14 September sampai dengan 21 Oktober 2021 dan didapatkan sampel 110 responden. Kepatuhan diet dinilai menggunakan kuesioner Perceived Dietary Adherence Questionnaire (PDAQ), kualitas hidup dengan kuesioner Abbreviated World Health Organization Quality of Life (WHOQOL-BREF) dan status gizi dengan pengukuran IMT.Hasil: Responden dengan kepatuhan diet rendah (50,9%) dan kepatuhan diet tinggi (49,1%). Status gizi obesitas yaitu 60,9%, status gizi lebih 11,8%, status gizi normal 21,8%, dan status gizi kurang 5,5%. Responden dengan kualitas hidup tinggi 3,6%, kualitas hidup sedang 68,2%, dan kualitas hidup rendah 28,2%. Hasil analisis korelasi spearman rank didapatkan hubungan antara kepatuhan diet dengan kualitas hidup pasien DM tipe 2 (p-value<0,001, r=0,513) dengan korelasi kuat (0,51 ≤ r ≤ 0,75) dan terdapat hubungan antara status gizi dengan kualitas hidup pasien DM tipe 2 (p-value<0,001, r=-0,332) dengan korelasi cukup (0,26 ≤ r ≤ 0,5).Simpulan : Terdapat hubungan antara kepatuhan diet dan status gizi dengan kualitas hidup pasien DM tipe 2. Semakin tinggi tingkat kepatuhan diet maka semakin tinggi kualitas hidup pasien DM tipe 2 dan semakin berlebih status gizi maka semakin rendah kualitas hidup pasien DM tipe 2.Kata kunci: Diabetes melitus tipe 2; Kepatuhan diet; Kualitas hidup; Status gizi.
A think-aloud method of investigating translanguaging strategies in learning Chinese characters
Authors: Zhang Qi , Lin Xu , Osborne Caitríona 
Published: October 2022

Abstract
Asian scripts that are significantly different from Roman-derived alphabets usually impose difficulties in learning. Translanguaging has therefore been explored as a pedagogical tool for the language classroom, including Chinese. While learning Chinese characters is thought to be one of the main challenges for students learning Chinese as a foreign language (CFL), there seems to be a paucity of up-to-date research into the strategies that adult students use to learn this logographic script. Situated in the translanguaging framework, this study employs the think-aloud method to investigate strategies utilised by a group of CFL beginner adult learners when learning characters. Drawing on the results of five think-aloud exercises with CFL learners over five weeks, as well as follow-up tests of their long-term memory of Chinese characters, this study shows that a variety of translanguaging strategies were utilised during the process of learning Chinese characters, and that overall three types of translanguaging strategies were observed: a) embodiment, b) translanguaging resemblance, and c) hybrid. The proposed typology of translanguaging strategies contributes to the further application of translanguaging as a methodology. It also sheds light on future learning strategy research across different linguistic systems.
Positivization time of a COVID-19 rapid antigen self-test predicts SARS-CoV-2 viral load: a proof of concept
Authors: Salvagno Gian Luca , Henry Brandon M. , Bongiovanni Giulio , De Nitto Simone , Pighi Laura , Lippi Giuseppe 
Published: October 2022

Abstract

Objectives
This proof of concept study was aimed to validate the hypothesis that the time of positivization of SARS-CoV-2 self-performed rapid diagnostic tests (RDTs) may reflect the actual viral load in the specimen.

Methods
A SARS-CoV-2 positive sample with high viral load was diluted and concomitantly assayed with molecular assay (Xpert Xpress SARS-CoV-2) and RDT (COVID-VIRO ALL IN RDT). The (mean cycle threshold; Ct) values and RDT positivization times of these dilutions were plotted and interpolated by calculating the best fit. The parameters of this equation were then used for converting the positivization times into RDT-estimated SARS-CoV-2 Ct values in routine patient samples.

Results
The best fit between measured and RDT-estimated Ct values could be achieved with a 2-degree polynomial curve. The RDT-estimated Ct values exhibited high correlation (r=0.996) and excellent Deming fit (y=1.01 × x − 0.18) with measured Ct values. In 30 consecutive patients with positive RDT test, the correlation between RDT positivization time and measured Ct value was r=0.522 (p=0.003). The correlation of RDT-estimated and measured Ct values slightly improved to 0.577 (Deming fit: y=0.44 × x + 11.08), displaying a negligible bias (1.0; 95% CI, −0.2 to 2.2; p=0.105). Concordance of RDT-estimated and measured Ct values at the <20 cut-off was 80%, with 0.84 sensitivity and 0.73 specificity.

Conclusions
This proof of concept study demonstrates the potential feasibility of using RDTs for garnering information on viral load in patients with acute SARS-CoV-2 infection.
Evaluation of the mechanical properties of different parts of bending bamboo culm by nanointendation
Authors: Wang Xuehua , Cao Mingxin , Ma Jingwen , Zhu Junjie , Lian Caiping , Fei Benhua , Xu Wei , Sun Fengbo 
Published: October 2022

Abstract
Bamboo is a flexible natural material, which has high potential value. However, manufacturing processes for bent bamboo products are highly reliant on manual labor. The main challenge in the industrial processing of raw bamboo is that bamboo’s characteristics have not yet been extracted accurately. This mainly originates from bamboo’s complexity and its response to bending, which depends on chemical composition, structure, and properties of bamboo. In order to understand the response of bamboo to bending, samples from different parts of manual processed bent bamboo culm ring were studied through nanoindentation tests. In this regard, elastic modulus, hardness, irreversible work, and residual depth on different bamboo parts were analyzed. The results show that bending has different effects on the tension side (TS, the convex side) and compression side (CS, the concave side) of the bamboo culm. Moreover, the bending effect was different on the green (GBP) and middle bamboo parts (MBP). It was found that bending improved the elastic modulus of GBP in TS by 101%. Moreover, the hardness of GBP in TS decreased by 21% while that of MBP increased by 12.4%. In CS, the hardness of GBP increased by 10% while that of MBP decreased by 19%. The performed analyses reveal that the ratio of irreversible work to total work increased in the bent bamboo and the difference between GBP and MBP was not large for both TS and CS. The relative residual depth was about 60% for the neutral side (NS) and increased to above 70% in TS and CS. It was proposed that either TS or CS formed a respective complete tension-compression stress system in the bent bamboo specimen.
The efficacy and safety of dipeptidyl peptidase-4 inhibitors and glucagon-like peptide-1 agonists in pediatric patients with type 2 diabetes: a systematic review
Authors: Li Xinyi , Sun Tong , Du Xin , Xie Xiaohui , Shi Luwen 
Published: October 2022

Abstract

Background
The incidence of type 2 diabetes mellitus (T2DM) in the pediatric population is increasing. There is a great need to develop more drugs for pediatric T2DM. Glucagon-like peptide-1 (GLP-1) agonists and dipeptidyl dipeptidase-4 (DPP-4) inhibitors have been approved for adults with T2DM and they might be effective in youths due to the similar pathogenic defects associated with T2DM. Here we aim to evaluate the efficacy and safety of GLP-1 agonists and DPP-4 inhibitors in pediatric patients with T2DM.

Contents
We performed a systematic review including trials comparing GLP-1 agonists and DPP-4 inhibitors against placebo in pediatric T2DM. This project was conducted based on the quality of reporting of meta-analyses (QUOROM) statement. Embase, PubMed, and Cochrane library were searched by two independent investigators for selecting relevant studies.

Summary and outlook
Five RCTs with a total sample size of 237 children were included. GLP-1 agonists showed superiority in glycemic improvement than placebo for pediatric T2DM. The advantage of DPP-4 inhibitors versus placebo for glycemic improvement is still unclear. GLP-1 agonists and DPP-4 inhibitors were well tolerated in pediatrics and further strictly designed trials are needed.
Towards a History of Syriac Rhetoric in Late Antiquity
Authors: Rigolio Alberto 
Published: October 2022

Abstract
This article presents the first comprehensive study of Syriac rhetoric in late antiquity. It builds on existing scholarship on the Syrians’ engagement with Graeco-Roman paideia and Christian rhetoric, but it also goes further in that it draws attention to the Syrians’ participation in Near Eastern rhetorical traditions (mainly transmitted through Aramaic) and in the rhetoric of the Hebrew Bible, which was translated into Syriac without Greek intermediaries. At the same time, this article demonstrates that Syriac rhetoric flourished in distinctive and original ways: It developed its own literary genres (with a strong predilection for poetry and a sensibility for gendered voices), performative settings (including the liturgy and the school), and thematic domains (notably Scriptural exegesis and religious controversy). It is especially remarkable that an elaborate “meta-rhetorical” reflection flourished in Syriac, as it first emerged in the work by Antony of Tagrit in the ninth century and in the broader context of late antique and Byzantine Aristotelianism. This comprehensive survey and its conceptual systematisation are designed to facilitate further research on Syriac rhetoric both during late antiquity and in later centuries, when the Syrians’ interaction with Arabic rhetoric came to play an increasingly influential role.
Syriac words are given in a simplified transcription. For consonants, the standard system in use for Semitic languages is followed; spirantisation of b g k p t is marked by v gh kh f th respectively. East Syrian vocalisation is generally adopted unless the words are quoted from a West Syrian author; vowel length is not marked, with the exception of a/ā and e/ē in Eastern Syriac.
A Skyline of Churches and Monasteries: The Changing Sacred Landscape of Oxyrhynchus in Late Antiquity
Authors: Dijkstra Jitse H. F. , Hidding Aaltje 
Published: October 2022

Abstract
The changing sacred landscape of Late Antiquity has long been seen in terms of a monolithic development ‘from temple to church’. Recent scholarship, however, has discarded this picture in favour of a more complex view, in which freestanding churches (and monasteries) were increasingly built from the fourth century onwards, while at the same time various, mostly practical, ways were found of dealing with the sacred built environment of the past. The Late Antique papyri from Oxyrhynchus contain dozens of references to churches and monasteries, and, occasionally, also temples. The city thus affords an excellent opportunity to study the changing sacred landscape of this period in a local context. In previous scholarship, several lists have been compiled to collect the attestations of churches. The last comprehensive collection of the material dates back two decades, however, while the one list of monasteries is heavily outdated. Moreover, a list of temples in the Late Antique papyri has never been put together. This article, then, presents, in the appendix, a brand-new Checklist of temples, churches and monasteries of Late Antique Oxyrhynchus. It serves as the basis for the detailed analysis of the data that precedes it, which shows that these data are in perfect agreement with the now prevalent general view among Late Antique scholars of how the sacred landscape changed over time. For comparison with the findings from the papyri, we will also briefly discuss the results of recent excavations at the site.
Crystal structure of catena-poly[diiodido-(μ2-1,5-dimethyl-2-phenyl-4-((pyridin-4- ylmethylene)amino)-1,2-dihydro-3H -pyrazol-3-one-κ2
N: O)zinc(II)], C17H16I2N4OZn
Authors: Li Ben , Huang Yujiao , Qian Weicheng , Pang Haixia , Tang Qiang 
Published: October 2022

Abstract
C17H16I2N4OZn, monoclinic, P21/n, a = 7.4827(5) Å, b = 14.9521(10) Å, c = 18.2838(13) Å, β = 99.251(1)°, V = 2019.0(2) Å3, Z = 4, R

gt
(F) = 0.0404, wR

ref
(F
2) = 0.787, T = 298 K.
The crystal structure of 3-nitrobenzene-1,2-dicarboxylic acid—pyrazine-2-carboxamide(1/1), C13H10N4O7
Authors: Jiang Cheng-Jun , Cheng Die , Xia Ying-Fan , Zhang Jia-rong , Lin Shu-ting 
Published: October 2022

Abstract
C13H10N4O7, monoclinic, P21/n (no. 14), a = 10.7017(7) Å, b = 7.1240(5) Å, c = 19.0878(13) Å, β = 99.280(3)°, V = 1436.19(17) Å3, Z = 4, Rgt
(F) = 0.0586, wRref
(F
2) = 0.1746, T = 296.15 K.
Synthesis of poly (N-isopropyl acrylamide-co-2-acrylamido methylpropane sulfonic acid) hydrogel containing copper and nickel nanoparticles with easy recycling and efficient catalytic potential
Authors: Riaz Muhammad , Ajmal Muhammad , Naseem Atif , Jabeen Nusrat , Farooqi Zahoor H. , Mahmood Khalid , Ali Abid , Rasheed Lubna , Saqib Ahmad Nauman Shah 
Published: October 2022

Abstract
Poly(N-isopropyl acrylamide-co-2-acrylamido methyl propane sulfonic acid) hydrogel was prepared and used as matrix for the fabrication of nickel and copper nanoparticles. Nickel and copper nanoparticles were fabricated via in situ reduction of Ni (II) and Cu (II) ions within the hydrogel matrix. The manufactured hydrogel and its corresponding composites with Ni and Cu nanoparticles were characterized by FTIR, XRD, EDX, TEM, and TGA. Thermal stability of hydrogel was found to be increased upon fabricating with metal nanoparticles. The hydrogel showed ability to absorb water 63 times of its weight in dried form. The Ni and Cu nanoparticles were observed to be well dispersed, spherical in shape and most of them were having diameters in the range of 12.5 to 38.8 nm and 58 to 102 nm, respectively. The as-prepared hydrogel-nickel and hydrogel-Cu nanocomposite were used as catalysts for the reduction of a toxic pollutant 4-nitrophenol. At 25 °C, the reduction of 4-NP was found to proceed with apparent rate constant (k
app) of 0.107 and 0.122 min−1 in the presence of composite containing Ni and Cu nanoparticles, respectively. However, k
app was increased with corresponding increase in temperature and its maximum value was found to be 0.815 min−1 at 88 °C with catalyst containing Ni nanoparticles. The formation of well dispersed Ni and Cu nanoparticles in the prepared hydrogel reflected that this hydrogel system can act as efficient stabilizing agent along with acting as a reactor medium. Recycling potential of catalysts was studied for five successive cycles.
Cortico-Subthalamic Field Potentials Support Classification of the Natural Gait Cycle in Parkinson’s Disease and Reveal Individualized Spectral Signatures
Authors: Louie Kenneth H. , Gilron Ro’ee , Yaroshinsky Maria S. , Morrison Melanie A. , Choi Julia , de Hemptinne Coralie , Little Simon , Starr Philip A. , Wang Doris D. 
Published: October 2022

AbstractThe ability of humans to coordinate stereotyped, alternating movements between the two legs during bipedal walking is a complex motor behavior that requires precisely timed activities across multiple nodes of the supraspinal network. Understanding of the neural network dynamics that underlie natural walking in humans is limited. We investigated cortical and subthalamic neural activities during overground walking and evaluated spectral biomarkers to decode the gait cycle in three patients with Parkinson’s disease without gait disturbances. Patients were implanted with chronic bilateral deep brain stimulation (DBS) leads in the subthalamic nucleus (STN) and electrocorticography paddles overlaying the primary motor and somatosensory cortices. Local field potentials were recorded from these areas while the participants performed overground walking and synchronized to external gait kinematic sensors. We found that the STN displays increased low-frequency (4–12 Hz) spectral power during the period before contralateral leg swing. Furthermore, STN shows increased theta frequency (4–8 Hz) coherence with the primary motor through the initiation and early phase of contralateral leg swing. Additional analysis revealed that each patient had specific frequency bands that could detect a significant difference between left and right initial leg swing. Our findings indicate that there are alternating spectral changes between the two hemispheres in accordance with the gait cycle. In addition, we identified patient-specific, gait-related biomarkers in both the STN and cortical areas at discrete frequency bands that may be used to drive adaptive DBS to improve gait dysfunction in patients with Parkinson’s disease.
Identification of the Acid-Sensitive Site Critical for Chloral Hydrate (CH) Activation of the Proton-Activated Chloride Channel
Authors: Xu Xiang-Ying , Zhang Fei-Fei , Gan Jun , Zhang Mao-Yin , Shen Zhong-Shan , Guo Qing , Teng Yue , Ji Jun-Wei , Cao Jun-Li , Tang Qiong-Yao , Zhang Zhe 
Published: October 2022

The transmembrane protein TMEM206 was recently identified as the molecular basis of the extracellular proton-activated Cl−channel (PAC), which plays an essential role in neuronal death in ischemia-reperfusion. The PAC channel is activated by extracellular acid, but the proton-sensitive mechanism remains unclear, although different acid-sensitive pockets have been suggested based on the cryo-EM structure of the human PAC (hPAC) channel. In the present study, we firstly identified two acidic amino acid residues that removed the pH-dependent activation of the hPAC channel by neutralization all the conservative negative charged residues located in the extracellular domain of the hPAC channel and some positively charged residues at the hotspot combined with two-electrode voltage-clamp (TEVC) recording in theXenopusoocytes system. Double-mutant cycle analysis and double cysteine mutant of these two residues proved that these two residues cooperatively form a proton-sensitive site. In addition, we found that chloral hydrate activates the hPAC channel depending on the normal pH sensitivity of the hPAC channel. Furthermore, the PAC channel knock-out (KO) male mice (C57BL/6J) resist chloral hydrate-induced sedation and hypnosis. Our study provides a molecular basis for understanding the proton-dependent activation mechanism of the hPAC channel and a novel drug target of chloral hydrate.SIGNIFICANCE STATEMENTProton-activated Cl−channel (PAC) channels are widely distributed in the nervous system and play a vital pathophysiological role in ischemia and endosomal acidification. The main discovery of this paper is that we identified the proton activation mechanism of the human proton-activated chloride channel (hPAC). Intriguingly, we also found that anesthetic chloral hydrate can activate the hPAC channel in a pH-dependent manner. We found that the chloral hydrate activates the hPAC channel and needs the integrity of the pH-sensitive site. In addition, the PAC channel knock-out (KO) mice are resistant to chloral hydrate-induced anesthesia. The study on PAC channels' pH activation mechanism enables us to better understand PAC's biophysical mechanism and provides a novel target of chloral hydrate.
Pathological Slow-Wave Activity and Impaired Working Memory Binding in Post-Traumatic Amnesia
Authors: Mallas Emma-Jane , Gorgoraptis Nikos , Dautricourt Sophie , Pertzov Yoni , Scott Gregory , Sharp David J. 
Published: October 2022

Associative binding is key to normal memory function and is transiently disrupted during periods of post-traumatic amnesia (PTA) following traumatic brain injury (TBI). Electrophysiological abnormalities, including low-frequency activity, are common following TBI. Here, we investigate associative memory binding during PTA and test the hypothesis that misbinding is caused by pathological slowing of brain activity disrupting cortical communication. Thirty acute moderate to severe TBI patients (25 males; 5 females) and 26 healthy controls (20 males; 6 females) were tested with a precision working memory paradigm requiring the association of object and location information. Electrophysiological effects of TBI were assessed using resting-state EEG in a subsample of 17 patients and 21 controls. PTA patients showed abnormalities in working memory function and made significantly more misbinding errors than patients who were not in PTA and controls. The distribution of localization responses was abnormally biased by the locations of nontarget items for patients in PTA, suggesting a specific impairment of object and location binding. Slow-wave activity was increased following TBI. Increases in the δ-α ratio indicative of an increase in low-frequency power specifically correlated with binding impairment in working memory. Connectivity changes in TBI did not correlate with binding impairment. Working memory and electrophysiological abnormalities normalized at 6 month follow-up. These results show that patients in PTA show high rates of misbinding that are associated with a pathological shift toward lower-frequency oscillations.SIGNIFICANCE STATEMENTHow do we remember what was where? The mechanism by which information (e.g., object and location) is integrated in working memory is a central question for cognitive neuroscience. Following significant head injury, many patients will experience a period of post-traumatic amnesia (PTA) during which this associative binding is disrupted. This may be because of electrophysiological changes in the brain. Using a precision working memory test and resting-state EEG, we show that PTA patients demonstrate impaired binding ability, and this is associated with a shift toward slower-frequency activity on EEG. Abnormal EEG connectivity was observed but was not specific to PTA or binding ability. These findings contribute to both our mechanistic understanding of working memory binding and PTA pathophysiology.