bluuebunny/crossref_metadata_2025_split huggingface dataset:
Atypical presentations of inclusion body myositis: Clinical characteristics and long‐term outcomes
Authors: Alamr Mazen , Pinto Marcus V. , Naddaf Elie 
Published: September 2022

AbstractIntroductions/AimsInclusion body myositis (IBM) typically presents with progressive weakness preferentially involving finger flexors and quadriceps. Atypical presentations have been less commonly reported. Here, we aim to describe the clinical characteristics and long‐term outcomes of IBM patients with atypical presentations.MethodsWe retrospectively searched the Mayo Clinic medical records to identify IBM patients with atypical disease onset, seen between 2015 and 2020.ResultsWe identified 357 IBM patients, of whom 50 (14%) had an atypical presentation. Thirty‐eight patients were diagnosed with IBM because they fulfilled one of the European Neuromuscular Center diagnostic categories at a later stage, 10 had all IBM histopathological features, and 2 were diagnosed on the basis of clinical and laboratory data. The most common presentation was dysphagia (50%), followed by asymptomatic hyperCKemia (24%; CK, creatine kinase), then foot drop (12%). 6% of patients presented with proximal arm weakness, 4% with axial weakness and 4% with facial diplegia. Median time from symptom onset to diagnosis was 9 y. Median age at diagnosis was 70.5 y. 16% of patients needed a walking aid. When tested, 86.5% of patients had impaired swallowing and 56% had elevated cytosolic nucleotidase‐1A antibodies. Only 1/26 patients who received immunotherapy had minimal improvement. Upon follow‐up, most patients had generalization of their weakness with a decline in their strength summated score of 0.082/mo.DiscussionA significant proportion of IBM patients may have an atypical presentation. Recognition of such heterogeneity could improve early diagnosis, prevent unnecessary immunotherapy, and provide insight for future diagnostic criteria development and clinical trials.
Expanded clinical spectrum of oculopharyngodistal myopathy type 1
Authors: Shimizu Takahiro , Ishiura Hiroyuki , Hara Manato , Shibata Shota , Unuma Atsushi , Kubota Akatsuki , Sakuishi Kaori , Inoue Kiyoharu , Goto Jun , Takahashi Yuji , Shirota Yuichiro , Hamada Masashi , Shimizu Jun , Tsuji Shoji , Toda Tatsushi 
Published: September 2022

AbstractIntroduction/AimsHeterozygous CGG repeat expansions in low‐density lipoprotein receptor–related protein 12 (LRP12) have recently been identified as a cause of oculopharyngodistal myopathy (OPDM), and the disease is designated as OPDM type 1 (OPDM1). In contrast to broadening of our knowledge on the genetic background of OPDM, what we know of the clinical phenotype of genetically confirmed OPDM1 remains limited.MethodsThis investigation was a single‐center case series study of OPDM consisting of ten patients from seven families. Repeat‐primed polymerase chain reaction and Southern blot analyses were performed to confirm the CGG repeat expansions in LRP12. Clinical findings were retrospectively reviewed.ResultsSeven patients from five families were identified as having CGG repeat expansions in LRP12. We found a high prevalence of axial muscle involvement, such as neck muscle weakness (6/7) and fatty infiltration in the rectus abdominis muscle, as revealed by computed tomography (5/5). We identified patients with very subtle oculopharyngeal symptoms, mimicking isolated distal myopathy. Muscle specimens were collected from the biceps brachii and tibialis anterior muscles of three patients. Myopathic changes were more severe with more atrophic fibers forming clusters in the tibialis anterior than the biceps brachii muscles of these three patients. No rimmed vacuoles were observed in the biceps brachii muscles in two of the three patients.DiscussionThis study shows the expanded clinical spectrum of OPDM1, highlighting the importance of axial muscle evaluation in OPDM1. Considering patients with very subtle oculopharyngeal symptoms, genetic analysis of LRP12 should be considered in patients with isolated distal myopathy.
Novel Glucosylimidazolium Ionic‐Liquid‐Supported Novozym 435 Catalysts – A Proof of Concept for an Acrylation Reaction
Authors: Lehmann Paul , Jopp Stefan 
Published: September 2022

AbstractInvited for the cover of this issue is the group of Stefan Jopp at the University of Rostock. The image depicts the conversion of acrylic acid and n‐butanol into butyl acrylate through an engine of Novozym 435, in which the powering piston CalB (Candida antarctica lipase B) is supported by the newly developed GMIM‐I (glucosyl‐methyl‐imidazolium iodide). The authors acknowledge Dr. Johanna Meyer (University of Hannover) for the creation of the cover image. Read the full text of the article at 10.1002/open.202200135.
Comprehensive characterization of novel Robusta (AAA) banana bracts fibers reinforced polylactic acid based biocomposites for lightweight applications
Authors: Ramasamy Siva , Karuppuchamy Amutha , Jayaraj Jeya Jeevahan , Suyambulingam Indran , Siengchin Suchart , Fischer Steffen 
Published: September 2022

AbstractBiocomposites have attracted researchers recently due to their biodegradability and environment‐friendly nature. The application of new fibers is increasing to reduce the fiber cost, and easy processing, and to meet the application‐specific properties in composite manufacturing. Banana is one of the most investigated plants for extracting fibers. Literature showed that the banana fibers were extracted from various parts of the plant. However, the potential of banana bracts is not discovered yet for composite manufacturing. In this work, the Robusta (AAA) variety banana bracts fibers (BBF) were prepared and used to make BBF reinforced polylactic acid (PLA) matrix biocomposites. Virgin PLA and BBF/PLA composites were prepared by two roll mills followed by compression molding. The characterization was carried out through X‐ray diffraction (XRD), Fourier transform infrared (FTIR), thermogravimetric analysis (TGA), and scanning electron microscopy (SEM), and the tensile, flexural, and impact properties were evaluated for Virgin PLA, BBF, and BBF/PLA composites. The FTIR results supported the incorporation of banana bracts in the composites by increasing the cellulosic and noncellulosic components. The SEM images supported the bonding of BBF in the PLA matrix. The BBF/PLA composite possessed the tensile strength of 40.15 ± 4.32 MPa, flexural strength (FS) of 87.13 ± 5.60 MPa, impact strength of 7.41 ± 0.56 kJ/m2, and a crystallinity index of 48.22%, which were significantly better than the virgin PLA. It was concluded that the BBF can be effectively used for making biocomposite with good mechanical strength.
Perinatal and long‐term outcome of endoscopic laser surgery for twin–twin transfusion syndrome with and without selective fetal growth restriction: A retrospective cohort study
Authors: Gibbone Elena , Campos Rosa Vallenas , Calero Antonio Jérez , Lucena Pilar Carretero , Molina Garcia Francisca S. 
Published: September 2022

AbstractObjectiveReport survival rates, neonatal mortality and morbidity and long‐term outcomes of monochorionic (MC) twin pregnancies complicated by twin‐to‐twin transfusion syndrome (TTTS) or TTTS plus selective fetal growth restriction (sFGR) treated by endoscopic laser surgery.MethodsRetrospective cohort study including 149 MC twin pregnancies complicated by TTTS or TTTS plus sFGR.Medical records were reviewed for survival rates, neonatal mortality, neonatal morbidity and long‐term outcomes at 2 and 6 years of age.ResultsSurvival of both babies was higher in the TTTS group than in the TTTS plus sFGR group (72.9%vs.54.8%); survival of at least one baby was similar in the two groups (90.7% and 88.1%). The incidence of severe neurological disability was not significantly different between TTTS and TTTS plus fetal growth restriction group at both stages, 1.9% versus 2.3% (p‐value = 1) and 3.4%vs6.1% (p‐value = 0.31). Multivariable analysis demonstrated that intact neurological outcome at 2 years of age was related with gestational age (GA) at birth and z score birthweight (Z BW), and at 6 years of age with GA at birth, Z BW and TTTS stage4. sFGR or abnormal brain findings at neonatal ultrasound were not related with impaired neurological outcome at two or 6 years of age.ConclusionsIn pregnancies with TTTS and TTTS plus sFGR survival of at least one baby and long‐term neurological outcome are comparable between both groups.
Asthma 17q21 polymorphism and risk of COVID‐19 in children: Correspondence
Authors: Mungmunpuntipantip Rujittika , Wiwanitkit Viroj 
Published: September 2022

AbstractThis correspondence discusses on published article on asthma 17q21 polymorphism and risk of COVID‐19 in children. The effect of other possible confounding factors are discussed.
Design and Development of Composite Propellant Using CuFe2O4 Spinel Decorated Graphene Oxide Nanocomposite as Novel Burn Rate Modifier
Authors: Ar Guruvayurappan , Dhas Akash M. , Pawar R. B. , Banerjee Shaibal 
Published: September 2022

AbstractThe burning rate of composite rocket propellant is a principal ballistic property that is considered while designing the rocket motor. Carbon bonded materials such as CNT(carbon nanotubes), fullerene, graphene, etc. due to their high surface area have exhibited promising results as burn rate modifiers in a propellant. Apart from enhancing the burn rate, unlike their inorganic counterparts, they are combustible and contribute towards energy output. Herein, we report a spinel structure CuFe2O4 decorated Graphene Oxide nanocomposite as novel burn rate modifier (BRM) in propellant composition. By incorporating 0.6 % of this burn rate modifier to the propellant remarkable improvement in burn rate by 61 % was observed.
Circuit Complexity in Topological Quantum Field Theory
Authors: Couch Josiah , Fan Yale , Shashi Sanjit 
Published: September 2022

AbstractQuantum circuit complexity has played a central role in recent advances in holography and many‐body physics. Within quantum field theory, it has typically been studied in a Lorentzian (real‐time) framework. In a departure from standard treatments, we aim to quantify the complexity of the Euclidean path integral. In this setting, there is no clear separation between space and time, and the notion of unitary evolution on a fixed Hilbert space no longer applies. As a proof of concept, we argue that the pants decomposition provides a natural notion of circuit complexity within the category of 2‐dimensional bordisms and use it to formulate the circuit complexity of states and operators in 2‐dimensional topological quantum field theory. We comment on analogies between our formalism and others in quantum mechanics, such as tensor networks and second quantization.
Using a knowledge translation program to facilitate guideline‐ and evidence‐based patient management: the PAH‐QuERI Extension Program
Authors: McLaughlin Vallerie V. , Channick Richard N. , Lynum Karimah S. Bell , Oudiz Ronald J. , Selej Mona , Tapson Victor F. , Rubin Lewis J. 
Published: September 2022

AbstractThe Pulmonary Arterial Hypertension‐Quality Enhancement Research Initiative Extension Program was designed to support physicians’ adherence to pulmonary arterial hypertension (PAH) guidelines. Guidelines were followed in >95% of patients with functional class (FC) II/III, but for only 28.6% of FC IV patients (Month 36). Low adherence was driven by FC IV patients’ preference to avoid parenteral treatment.
ANCAnegative eosinophilic granulomatosis with polyangiitis (EGPA) presenting with left ventricular thrombus: An appreciation of distinct phenotypes and eosinophilic driven pathogenesis
Authors: Chaivannacoopt Kai , Flanagan Eliza 
Published: September 2022

AbstractEosinophilic granulomatosis with polyangiitis (EGPA) is a rare multisystem disorder, included in the spectrum of the antineutrophil cytoplasmic antibodies (ANCA) associated vasculitides. There are heterogeneous clinical features and a lack of consensus in standardized diagnostic criteria, with an underappreciation of eosinophilic manifestations. There are now reported phenotypical differences betweenANCA‐positive and negativeEGPA, with myocardial involvement, lung infiltrates and gastrointestinal symptoms predominating inANCA‐negative cases. We report a rare presentation ofANCA‐negativeEGPAin a woman with respiratory, neurological and cardiac involvement, manifesting as a large left ventricular thrombus without significant cardiac dysfunction.
Improving sustainability teaching by grouping and interrelating pedagogical approaches and sustainability competences: Evidence from 15 Worldwide Higher Education Institutions
Authors: Lozano Rodrigo , Barreiro‐Gen Maria , D'Amato Dalia , Gago‐Cortes Carmen , Favi Claudio , Martins Ricardo , Monus Ferenc , Caeiro Sandra , Benayas Javier , Caldera Savindi , Bostanci Sevket , Djekic Ilija , Moneva Jose Mariano , Sáenz Orlando , Awuzie Bankole , Gladysz Bartlomiej 
Published: September 2022

AbstractThere has been increasing research on pedagogical approaches, sustainability competences, and how to connect them in Higher Education Institutions (HEIs). This paper's aim is to provide deeper insights into the system of pedagogical approaches and sustainability competences, as well as how these interrelate. A survey was developed to investigate sustainability teaching in 15 HEIs. The survey was sent to educators of each HEI from which 668 responses were obtained. The responses were analysed in a five‐step process: (1) descriptive statistics; (2) Pearson correlations; (3) principal component analyses (PCAs) to detect groups; (4) Pearson correlations between the groups; and (5) regressions. The first step provided the base to carry out the PCAs, from which three groups for the pedagogical approaches (Universal, Social, and Environmental) and three for the sustainability competences (Extrospective‐social, Introspective‐personal, and Cogitative‐processual) were obtained. The correlations between the groups showed that: (1) the competences are closely interrelated; (2) the pedagogical approaches are somehow interrelated; and (3) the pedagogical approaches are somehow interrelated to the competences. The regressions showed that the Universal and Social groups would be most suitable to develop all the competences' groups. The Environmental group develops only the cogitative‐processual competences' group. The results served as bases to propose the Sustainability Teaching System (STS), which provides deeper insights into the system of pedagogical approaches and sustainability competences by grouping them, as well as showing directionality and strength. To improve sustainability teaching, it is necessary to understand the pedagogical approaches' groups and how they can develop the competences' groups.
A Comprehensive Account of Synthesis and Biological Activities of α‐lidene‐ Benzocycloalkanones and Benzoheterocycles
Authors: Chowdhury Moumita Ghosh , Das Rudradip , Vyas Het , Sasane Tejal , Mori Omprakash , Kamble Sayali , Patel Sagarkumar , Shard Amit 
Published: September 2022

Abstractα‐lidene‐benzocycloalkanones or benzene‐fused cycloalkanones are a significant moiety in medicinal chemistry. Drug development using these moieties can explore the pharmacophoric space owing to their sp2 and sp3 hybridization, highly flexible bicyclic structure, and varied ring diameters. In addition, it imparts a more significant contribution based on stereochemistry and pliability in the three‐dimensional space. The α‐lidene‐benzocycloalkanone series is a challenging target as it has multiple reactive sites, such as the bicyclic benzo‐annulated center, the reactive carbonyl fragment, and the partly hydrogenated ring of varying sizes. This domain lacks discussion and organized material, and this review can fill that gap, focusing on medicinally essential moieties like tetralone, indanone, and suberine. In addition, this review discusses α‐lidene‐benzoheterocycles that are promising in the field of drug development. Due to their stereogenecity and target selectivity, most research and applications focus on unstrained 5 and 6‐membered rings, such as α‐lidene‐benzocyclopentanones, α‐lidene‐benzocyclohexanones, α‐lidene‐benzofurano‐3‐ones, α‐lidene‐benzopyrano‐3‐ones, and α‐lidene‐indolin‐3‐ones. This review shall also aid medicinal chemists in determining the optimal technique for developing novel benzene fused heterocycles or carbocycles with various biological activities.
An Unexpended Stereocontrolled Rearrangement of Ethyl 4‐Hydroxy‐4‐(substituted phenyl)‐2‐butynoate to Tetrasubstituted Alkenes with MeSOCl2
Authors: Anil Derya Aktas 
Published: September 2022

AbstractTetrasubstituted alkene derivatives are synthetically important compounds and one of the important research areas in organic chemistry. Stereoselective synthesis of all‐carbon tetrasubstituted alkenes is a challenging problem in chemical synthesis because of the uncontrolled Z/E stereoselectivity. Here we described an unexpended stereocontrolled rearrangement for the synthesis of tetrasubstituted alkenes, each group different from the other. The reaction of ethyl 4‐hydroxy‐4‐(substituted phenyl)‐2‐butynoate derivatives with methanesulfonyl chloride and triethylamine gave in an interesting manner syn‐selective tetrasubstituted alkene, containing the sulfonate ester and the chlorine atom. The Z‐configuration of the chlorovinyl sulfonate esters was determined by X‐ray crystal analysis. The parameters (such as amount of equivalent, solvent, and temperature) that will affect product formation were examined and the optimum conditions for formation were determined.
Electrochemical Sensor for the Anti‐tuberculosis Drug Rifampicin on CuO@rGO‐Nanocomposite‐Modified GCE by Voltammetry Techniques
Authors: Sagar Pinky , Srivastava Monika , Srivastava Sanjay K. 
Published: September 2022

AbstractReduced‐graphene‐oxide layers (rGO) offer extremely subtle transducer thin‐films and can be unified in interdigital micro‐electrodes for various purposes. Understanding the functions and nature of rGO specially bio‐compatibility, we can use this as potent‐tool for the detection of antibiotic‐drug Rifampicin (RFP) in standard/pharmaceutical samples. Herein, we synthesize CuO@rGO nano‐composite and explored its potency for the preparation of electrochemically‐active‐electrodes. Catalytic‐activity of as‐synthesized CuO@rGO nano‐composite is checked in 1.0 mM of Fe2+/3+ solutions and found to be more than three times higher current as compared to bare, rGO or CuO modified GCE. Subsequently, modified electrodes are used to detect RFP via two‐techniques (differential‐pulse voltammetry viz. DPV and cyclic‐voltammetry viz. CV) in three‐ways simultaneously. The CuO@rGO‐modified‐GCE (CuO@rGO/GCE) exhibits remarkable sensitivity with very low‐detection‐limit of 5–11 nM and long term‐usage, which is far‐better than other reported works. Non‐interfering ability in existence of several body‐interferents exposes that CuO@rGO/GCE could be an effective/ beneficial contrivance for the detection of RFP.
Highiy Efficient Water Splitting with Polyoxometalate Coated on Deliberately Designed Porous Carbon as a Bifunctional Electrocatalyst
Authors: Liu Huimin , Liu Chang , Zong Xing , Chen Ketong , Yao Wangdong , Su Yunhao , Qian Huayun , Wang Yongfei , Chou Shulei , Hu Zhizhi , Zhang Zhiqiang 
Published: September 2022

AbstractRational design of efficient, sustainable and low‐cost hydrogen evolution reaction (HER) and oxygen evolution reaction (OER) bifunctional catalysts within the scope of feasibility is of great significance for realizing rapid output water splitting. Here, we used a simple coprecipitation method to prepare Keggin‐type polyoxometalate (POM) nanoscale particles coated with core‐shell‐type metal‐organic framework (MOF) derived Co‐NC (Co‐NC‐POM). Thanks to synergy effect, abundant active sites, unique structure and defects, the as‐synthesized Co‐NC‐POM hybrids exhibit excellent eletrocatalytic performance both for HER and OER. Moreover, it can act as bifunctional electrocatalysts for overall water splitting, exhibiting a low voltage of 1.60 V and an excellently stability up to 24 h at a current density of 10 mA cm−2. It shows competitive performance against the same type of advanced bifunctional catalysts currently reported and thus is expected to among the most efficient non‐precious metal catalysts to drive the water splitting device.
Surfactant‐Enhanced Nano Spinel Oxide for Applications in Catalysis, Dye Degradation and Antibacterial Activity
Authors: Nivetha Ambikapathi , Prabha Inbaraj 
Published: September 2022

AbstractNovel surfactant supported Mn−Co−Ni oxide was effectively synthesized by simple and economic co‐precipitation method to investigate the efficiency of catalytic reduction of 4‐nitrophenol, degradation of methylene blue and antibacterial properties. The optical, structural and chemical compositions were cautiously analyzed by X‐ray diffraction (XRD), Field emission scanning electron microscopy (FESEM), X‐ray photoelectron microscopy (XPS), ultraviolet‐visible (UV‐Vis), Fourier transform infrared (FT‐IR), Brunauer‐Emmett‐Teller (BET) and dynamic light scattering (DLS) analyses. XRD analysis showed cubic structure with average crystallite size of 19–21 nm. FESEM images confirmed the combination of spherical, needle, plate and rod like shapes. Accordingly, a high specific surface area of 55.66 m2 g−1 was achieved by urea/Mn−Co−Ni oxide. Band gap of ternary metal oxide was found in the range of 3.4‐3.6 eV. The XPS analysis confirmed the presence of manganese, cobalt and nickel as major parts with a 2p core level region. The M−O bond formation was confirmed by the peak appeared in the range of 500–600 cm−1. The negative charge of ternary metal oxide was confirmed by negative zeta potential value. The reduction of 4‐nitrophenol was carried out by Mn−Co−Ni oxide with the efficiency of >99 % and the degradation efficiency against methylene blue was studied. The synthesized catalyst was potent against S. aureus at higher concentration.
Color‐Tunable Single‐Phase Bi3+/Eu3+‐Activated LiCa3ZnV3O12 Luminescence Materials Based on Energy Transfer
Authors: Jiao Haiyan , Zhang Guoheng , Chen Wanjun , Chen Qiong , Wang Peiyu , Wang Yuhua 
Published: September 2022

AbstractTo achieve high‐quality WLED (White light emitting diodes) lighting, it is essential to accurately control the emission color of phosphor materials. The LiCa3ZnV3O12 : Bi3+/Eu3+ phosphors were synthesized by a traditional high‐temperature sintering reaction and characterized using XRD, SEM, Fluorescence Spectrophotometer. This paper firstly reported the luminescence properties of Bi3+ single‐doped garnet phosphors LiCa3ZnV3O12. Based on local lattice distortion and the energy transfer of VO43−→Bi3+, the luminescence color of LiCa3ZnV3O12 : Bi3+ could be adjusted from blue‐green (490 nm) to yellow‐green (517 nm) under NUV excitation. In addition, Bi3+→Eu3+ energy transfer was designed by Bi3+ and Eu3+ double doping, and full color emission tuning from blue to blue‐green and then to pink and white was successfully realized. The energy transfer mechanism, luminescence chromaticity coordinates and thermal stability are studied in detail. More significantly, by constructing efficient energy transfer between Eu3+ and Bi3+, the thermal stability of as‐synthesized samples are gradually improved. This paper proposes a new direction for the color tuning of phosphors through multiple energy transfers and local lattice distortion.