bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mobile Health Application for Seizure Management: A Human-Systems Integration Approach
Authors: Lazaro May Jorella , Alvaran Alysson , Yun Myung Hwan , Kim Sungho 
Published: March 2022

Objective The study aims to develop a mHealth application for seizure management based on the human system integration (HSI) approach. Background Unmet healthcare needs among people with epilepsy continue to exist despite the advancement in healthcare technology. Current seizure management methods are found to be ineffective. Therefore, a more efficient strategy such as mHealth technology is necessary to aid seizure management. Method The needs identification phase involved identifying the user requirements by interviewing 10 stakeholders and conducting thematic analysis and needs interpretation technique. In the solution identification phase, the system requirements were derived using various human-centered design and systems engineering approaches and were evaluated through quality function deployment to determine design targets. For the design and evaluation phase, the design targets were reflected in the app through the iterative prototyping process, and the interface and functional design were evaluated by seven human factors and ergonomics experts and four stakeholders, respectively. Results Three primary needs and ten user requirements were derived from the needs identification phase. Ten out of fifteen system requirements were selected as design targets to be included in the final prototype. Results of the evaluation showed that the interface design of the proposed app showed superior usability compared to a competitor app and that the app functions were beneficial for the stakeholders. Conclusion The mHealth app designed through the HSI framework showed good potential in addressing the main issues in seizure management. Application The mHealth app design methodology based on the HSI approach can be applied to the design of small-scale systems in various domains.
Migration of a Fish Bone From the Esophagus to the Thyroid Gland
Authors: Huang Hsiao-Yu , Wang Chien-Chung 
Published: March 2022

Accidental swallowing of fish bone is one of the most common emergencies in the otolaryngology department. The impacted fish bones are usually found in the palatine tonsil, base of the tongue, valleculae, pyriform sinus, and esophagus, which can be successfully removed after a thorough examination. However, in some cases, the fish bone may penetrate into the neck soft tissue and migrate to extraluminal organs, causing infection, abscess formation, or rupture of vessels. In such cases, prompt recognition and immediate removal of the impacted fish bone are necessary. Herein, we report a rare case of a 60-year-old woman who had accidently swallowed a fish bone 10 days prior to visiting the outpatient department. The fiberoptic scope and head and neck computed tomography scans were obtained from the outpatient department. The fish bone was found to migrate from the upper esophagus to the left thyroid gland. First, a rigid esophageal endoscopy was performed in the operating room, but no obvious fish bone was noted over the esophagus. Finally, the fish bone was removed via exploratory cervicotomy with left-sided total lobectomy of the thyroid. The patient recovered after the operation, and there were no further complications during the 3 years of follow-up.
Long‐Term Quality of Life of Vestibular Schwannoma Patients: A Longitudinal Analysis
Authors: Neve Olaf M. , Jansen Jeroen C. , Koot Radboud W. , Ridder Mischa de , Paul G. van Benthem Peter , Stiggelbout Anne M. , Hensen Erik F. 
Published: March 2022

AbstractObjectiveVestibular schwannoma management aims to maintain optimal quality of life (QoL) while preventing severe sequelae of the tumor or its treatment. This study assessed long‐term QoL of patients with vestibular schwannoma in relation to treatment modality and decisional regret.Study DesignA longitudinal study, in which clinical and QoL data were used that were cross‐sectionally acquired in 2014 and again in 2020 from the same patient group.SettingA tertiary expert center for vestibular schwannoma care in the Netherlands.MethodsQoL was measured by the Penn Acoustic Quality of Life (PANQOL) scale. Changes in time were assed using a linear mixed model. In addition, the Decision Regret Scale was analyzed.ResultsOf 867 patients, 536 responded (62%), with a median follow‐up of 11 years. All PANQOL subdomain scores remained stable over time and did not exceed minimal clinically important difference (MCID) levels. Time since treatment did not affect QoL. Patients had comparable average QoL scores and proportions of patients with changing QoL scores (ie, exceeding the MCID) over time, irrespective of the received initial treatment. Female patients and those who required salvage therapy (either by radiotherapy or surgery) reported a lower QoL. The latter patient group reported the highest decisional regret.ConclusionOn average, the long‐term QoL of patients with vestibular schwannoma is comparable for patients under active surveillance and those who have received active treatment, and it remains stable over time. This suggests that, on average, preservation of QoL of patients with vestibular schwannoma is feasible when adequately managed.
Oropharyngeal Rehabilitation for Patients With Moderate to Severe Obstructive Sleep Apnea After Transoral Robotic Surgery
Authors: Lai Yi‐Ju , Su Po‐Lan , Li Chung‐Yi , Lin Chung‐Ying , Hung Ching‐Hsia , Lin Cheng‐Yu 
Published: March 2022

ObjectiveTo determine whether combined transoral robotic surgery and postoperative oropharyngeal rehabilitation are effective for reducing the severity of obstructive sleep apnea.Study DesignA quasi‐experimental study enrolled participants without blinding between May 2019 and April 2021.SettingSingle‐center study at National Cheng Kung University Hospital.MethodsPatients with moderate to severe obstructive sleep apnea who were otherwise healthy were recruited from the ear, nose, and throat department at National Cheng Kung University Hospital. The group undergoing transoral robotic surgery with oropharyngeal rehabilitation (n = 18) received a 12‐week intervention consisting of home‐based rehabilitation exercises following surgery; the transoral robotic surgery group (n = 17) received surgery only; and the control group (n = 15) received conservative treatment, such as continuous positive airway pressure therapy or other oral appliance therapy. Polysomnography data and tongue muscle performance were measured before and after the interventions.ResultsThe group that underwent transoral robotic surgery with oropharyngeal rehabilitation exhibited significantly improved tongue protrusion strength as compared with the transoral robotic surgery–only group, as well as significantly improved apnea‐hypopnea index in the supine position vs the control group.ConclusionIn this study, we demonstrated the synergistic effects of transoral robotic surgery and postoperative oropharyngeal rehabilitation for adult patients with obstructive sleep apnea. Objective records should be used to monitor home‐based rehabilitation exercises and examine the lasting synergistic effects.
Clinical evaluation of the novel Capiox NX19 adult oxygenator–a multicenter study
Authors: Hendrix Rik H J , Debeuckelaere Gerdy , Degezelle Karlien , Lenaerts Lieven , Verbelen Tom , Weerwind Patrick W 
Published: March 2022

Introduction The novel Capiox NX19 adult oxygenator is, compared to its predecessors, improved with enhanced air removal technology, a polymer heat exchanger and smaller, innovative hollow fibers resulting in a surface area reduction and a lower priming volume. The aim of this study was to evaluate the NX19 oxygenator performance in a clinical setting. Methods A prospective multicenter study was performed involving three large European university hospitals. The Capiox NX19 ( n = 150) performance was assessed during adult cardiopulmonary bypass and involved gaseous microemboli handling and gas transfer efficiency. The heat exchanger performance was evaluated separately in vitro. Results The heat exchanger performance factors were 0.80 ± 0.03 and 0.58 ± 0.04 at pump flow rates of 3 L/min and 6 L/min, respectively. After priming, residual post-oxygenator gaseous microemboli count and volume were decreased by 91% and 93.7%, respectively. The gas compartment pressure was 6.0 ± 2.5 mmHg, while the O2 transfer was 69 ± 30 mL/min/m2 and the CO2 transfer 73 ± 34 mL/min/m2. The O2 gradient was 44 ± 19 mmHg/LPM and the O2 diffusing capacity 0.38 ± 0.14 mL/min/mmHg. The shunt fraction was 0.19 ± 0.13, whereas oxygenator resistance and shear stress were 10.5 ± 3.7 mmHg/LPM and 5.1 ± 3.1 dyn/cm2, respectively. Conclusion This multicenter study displayed good clinical safety and performance of the NX19 oxygenator.
A novel natural-derived tilapia skin collagen mineralized with hydroxyapatite as a potential bone-grafting scaffold
Authors: Yao Shiyu , Shang Yuli , Ren Bo , Deng Shu , Wang Zhe , Peng Yang , Huang Zhaohui , Ma Shiqing , Peng Cheng , Hou Shuai 
Published: March 2022

Collagen is widely used in medical field because of its excellent biocompatibility and bioactivity. To date, collagen for biomedical use is always derived from bovine or swine. The purpose of this study was to evaluate collagen-based biomaterials from non-mammalian donors for bone repair. Thus, tilapia skin collagen-hydroxyapatite (T-col/HAp) scaffolds were fabricated in three different proportions and then cross-linked with 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide-N-hydroxysuccinimide (EDC-NHS). The scaffolds were evaluated for their microstructure, chemical and physical properties, mechanical strength and degradability. Then the in vitro responses of bone mesenchymal stem cells (BMSCs) to the scaffolds were investigated in terms of cellular proliferation, differentiation, and mineralization. At last, the scaffolds were implanted into rat skull critical defections to investigate the potential of osteogenic activities. As a result, the pore sizes and the porosities of the scaffolds were approximately 106.67–196.67 μm and 81.5%–66.7%. Pure collagen group showed a mechanical strength of 0.065 MPa, and the mechanical strength was significantly enhanced almost 17 times and 32 times in collagen/HAp ratio 1:4 and 1:9 groups. In vitro studies revealed the most prominent and healthy growth of BMSCs in collagen/HAp ratio 1:4 group. All the scaffolds showed certain osteogenic activities and those loaded with small amount of hydroxyapatite showed the strongest bioactivities. The micro-CT showed that the critical bone defect was almost filled with generated bone 6 months after implantation in collagen/HAp ratio 1:4 group. The biomechanics tests further confirmed the highest generated bone strength was in the collagen/HAp ratio 1:4 group. This study indicated aquatic collagen might be a potential alternative for type I collagen from mammals in bone tissue engineering. The combination of collagen and inorganic materials was also important and appropriate inorganic component loading can achieve both osteogenic quality and osteogenic efficiency to a certain extent.
Study on vinyl crosslinking and related properties of silicon-containing arylacetylene resin synthesised by zinc powder catalysis
Authors: Dong Sensen , Chen Fan , Wang Guihui , Hu Wei , Zhao Chuanqing , Hu Yanhong , Deng Shifeng 
Published: March 2022

A matrix resin poly(silicon-containing arylacetylene vinyl)s (PSAV) containing vinyl at both branch and terminal chains underwent synthesis via the zinc powder catalytic method using m-diacetylene benzene and dichloromethylvinylsilane as raw materials. Vinyl in the PSAV resin was crosslinked by the free radical initiator dibenzoyl peroxide to obtain a crosslinked network structure resin (PSAV-L). This approach sought to improve the thermal properties and other related properties of the matrix resin. A series of tests, such as rotated rheometer, FTIR, DSC, TGA, Py-GC-MS and universal testing machine, characterised processing property, curing behaviour, thermal properties and mechanical properties. The rheological curve shows that PSAV-L resin has a wide processing window (40–134.5°C), endowing the resin with excellent processing performance. Thermal curing behaviour indicates that PSAV-L resin can start curing at a lower temperature, namely, 32°C earlier than PSAV resin. TGA analysis shows that the degradation temperature at 5% weight loss (Td5) of PSAV-L resin stands at 579.4°C, 45.4°C higher than that of PSAV resin due to the fact that the crosslinking of vinyl gives PSAV-L resin a network structure. The flexural strength, flexural modulus and ILSS of the quartz fibre cloth reinforced PSAV-L resin composite (QF/PSAV-L) are 184.68 MPa, 15.50 GPa and 12.40 MPa. The PSAV-L resin exhibits the comprehensive properties of good processing performance, low curing temperature, excellent thermal performance and high mechanical properties.
Flight performance of helicopter tail rotors with extendable chord
Authors: Yang Kelong , Han Dong 
Published: March 2022

To investigate the potential of Statically and Dynamically Extendable Chord (SEC/DEC) in performance improvement of helicopter tail rotors, a prediction model of helicopter flight performance is developed and validated. It is suitable to deploy the SEC and DEC close to the blade tip for power reduction of tail rotor in hover and high-speed flight. The deployment locations of SEC and DEC for tail rotors are similar to that of main rotors. In hover, the deployment of the SEC and DEC results in little power reduction. From low to medium speed flight, the deployment of the DEC and SEC increases the power. In high-speed flight, the SEC and DEC can significantly decrease the power, especially at a large take-off weight. At 300 km/h, when the chord extension is 20% of blade chord, the SEC and DEC with 1/rev input decrease the power by 14.44% and 20.47% at a take-off weight coefficient of 0.0091. The DEC shows greater potential in power reduction than the SEC. There is an optimal phase input for the maximum power reduction, which does not vary with forward speed. For the DEC with 1/rev input, the optimal phase is [Formula: see text]. The optimal phase input for the maximum power reduction of tail rotors is different from that of main rotors.
Donor graft harvesting with air in pterygium surgery
Authors: Moscovici Bernardo Kaplan , Rodrigues Pablo Felipe , Freitas Marcela Mara Silva , e Silva Francisco Bandeira , Felberg Sérgio , Dantas Paulo Elias Correa 
Published: March 2022

Purpose Report a new technique for improvement of pterygium surgery: donor graft harvesting with air. Case reports We describe a technique that was used with 138 patients who underwent surgery that included a conjunctival autograft and fibrin glue with air injection to dissect the Tenon capsule from the conjunctiva. Results No complications occurred with this technique and all patients achieved good results. Discussion The surgical time with this new technique was similar to that reported in the literature. In addition, the graft thickness was close to that reported with femtosecond laser dissection and it was thinner than that reported with aesthetic/saline dissection (unable to determine statistical significance). Conclusions and importance With the injection of an air bubble, we could easily dissect the conjunctiva from the Tenon capsule and quickly acquire thin grafts without any additional costs or complications.
Substance Use in Healthcare Professionals During the COVID-19 Pandemic in Latin America: A Systematic Review and a Call for Reports
Authors: Moya-Salazar Jeel , Nuñez Elizabeth , Jaime-Quispe Alexis , Zuñiga Nahomi , Loaiza-Barboza Isabel L , Balabarca Edison A , Chicoma-Flores Karina , Cañari Betsy , Contreras-Pulache Hans 
Published: March 2022

Background: The COVID-19 pandemic has generated a remarkable change in the behaviour of Healthcare workers (HCWs) around the world. However, there is a lack of evidence on substance use among HCWs in Latin America. Therefore, this study aimed to determine the current frequency of substance use among Latin American among HCWs. Methods: We searched 8 databases (PubMed, Scopus, ScientDirect, Web of Science, Cochrane, Scielo, LILACS and Latindex), 4 public prepublication servers (SocArXiv, medRxiv, bioRxiv and Preprints) and Google scholar from 1/9/2019 to 11/1/2021. We determined the frequency of each study based on original studies, scientific letters, and clinical trials in English, Spanish and Portuguese. Results: A total of 17 175 study articles were identified from electronic databases and preprints, and 2 cross-sectional studies conducted in 2020 were included in the qualitative analysis. Both studies included HCWs but did not perform a differential analysis. The first was developed by the Pan-American Health Organization and included interviewees from 35 countries, while the second was conducted with 1145 Brazilian participants. Both studies showed increases in substance use during the pandemic, with alcohol being the most commonly used substance (30%), but PAHO’s study reported a 13.8% increase in self-reported heavy-episodic drinking, with differences among genders (males, 15.4%), age groups (highest increase in the 40-49 age group, 16.5%) and area of residence (urban with 14%). The second study showed that 21 32% of participants reported initiating psychoactive substance use, 29.3% added some substance to their initial use and 4% of them had to replace the substance, mainly due to difficulty of access. Other substances of abuse that showed significant increases were tobacco (0.5%) and marijuana (0.3%). Conclusion: Overall, despite the analysis of the 2 studies, the results provided are not a conclusive description of the frequency of substance use by HCWs in Latin America during the COVID-19 pandemic. Further research is required to understand the impact of the pandemic on drug abuse in the region. Protocol Registration: The protocol has been registered on 30 November 2021 on the International Prospective Register of Systematic Reviews (PROSPERO) with ID: CRD420212919700.
Variation in first-generation L1 deictic systems: Language attrition and bilingualism effects
Authors: Vulchanova Mila , Collier Jacqueline , Guijarro-Fuentes Pedro , Vulchanov Valentin 
Published: March 2022

Aims and Objectives: This study explored the extent to which bilingual language exposure and practice might alter the way in which bilingual first-generation adult speakers use deictic demonstratives in their first language (Spanish) after immersion in a new language environment (Norwegian). Fully developed L1 systems are expected to be stable and less susceptible to change or restructuring than child systems. In addition, core domains of a language such as deictic demonstrative reference are hypothesized to be more robust. Design: Participants were tested with the Spanish version of the memory game. They completed an ethnolinguistic background questionnaire with questions targeting demographic data, experience with language, and daily routines in language use. Data and analyses: Demonstrative use was analysed using binomial multilevel modelling, allowing residual variance to be partitioned into a between-participant component and a within-participant component. Findings: Results demonstrate a shift in the demonstrative system of Spanish native speakers who have resided in Norway for a median of 6.5 years. This shift is reflected in extensive use of the semantically underspecified item ese at the expense of the form aquel. The latter form is less frequent and highly context-dependent in corpora of the modern language. It can be hypothesized that first-generation speakers are faster in converging on a simplified system of deictic reference than the native speaker group tested in Spain, but this development parallels tendencies observed in the monolingual variety of the language. This faster shift may well be influenced and catalysed by bilingual language practice. Originality: This article addresses a gap in research on deictic terms under conditions of language attrition. It documents a restructuring of the deictic system in first-generation speakers of Spanish residing in another country. The results suggest that marking peri-personal space is a core feature of deictic systems across languages, also preserved under deictic system shift.
The attitudes of Vietnamese social work practitioners toward sexual minorities
Authors: Le Trang Mai , Yu Nilan 
Published: March 2022

Summary Social workers are expected to challenge the exclusion and oppression of marginalised populations which requires the critical interrogation of prejudicial views, discriminatory attitudes, and oppressive practices. In this regard, social work practitioners need to be vigilant of their own attitudes toward the people they serve. This is relevant to social work practice with sexual minorities. This paper presents the results of a mixed-methods study informed by a critical theoretical frame that explored Vietnamese social work practitioners’ attitudes toward sexual minorities. The findings presented in this article were drawn from a survey of 292 social work practitioners based in Hanoi, Vietnam and 12 semi-structured interviews with volunteers recruited from the pool of survey participants. Findings The findings suggest that practitioners who participated in this study held relatively positive attitudes toward people who identify as lesbian or gay. However, those who had what could be considered moderate to positive attitudes were not necessarily free from prejudicial and discriminatory views, particularly when it came to certain matters such as those relating to their own families and work with young children. Applications The discussion of the findings illustrate the relevance of the broader social context to Vietnamese social work practitioners’ attitudes toward sexual minorities. It highlights the potent influence of dominant ideologies in shaping prejudicial views and attitudes and points to the need for practice at a broader level targeting Vietnamese society and culture as a whole.
Postvaricocele Embolization Pain Syndrome: A Case Series Report and Review of Current Treatment Strategies
Authors: Chung Eric 
Published: March 2022

Background: Orchialgia is not an uncommon complaint among men with varicocele, but postvaricocele embolization–related testicular pain has not been widely investigated. This study evaluates the phenomenon of postvaricocele embolization pain (PVEP) syndrome and examines the current strategies to treat this unusual complication. Methods and materials: A prospectively collected database of patients with PVEP who presented to a tertiary center was analyzed between January 2011 and January 2020 following internal ethics approval. Patient demographics, including other complications related to embolization, analgesic requirements, and pain scores (on a 10-point visual analog score), treatment strategies, Patient Global Impression of Improvement (PGI-I) score and overall satisfaction score (on a 5-point scale), were reviewed. All patients were reviewed for a minimum of 12 months. Results: A total of 20 men with a mean age of 33.8 (18–45) years old, presented with PVEP over 10 years. Most men received embolization on an average of 26.6 (18–48) months. The reasons for varicocele embolization include either isolated or combined orchialgia (15 men), subfertility (5 men), and cosmesis (6 men). Eighteen (90%) men underwent microscopic spermatic cord denervation (MSCD) and 2 patients elected for conservative measures. The average pain scores pre-MSCD and post-MSCD were 6.9 (4–9) and 1.4 (0–4) (p<0.001) with a significant reduction in analgesia requirements. Immediate improvement in pain score was reported in all the patients and this persisted at the 12 months review. Most men reported a high satisfaction score (of 4/5) and only one patient reported no change in symptoms after MSCD. Conclusion: PVEP is a unique complication and patients should be counseled on the potential risk of persistent orchialgia following embolization for varicocele. The MSCD appears to be an effective treatment option with high success and satisfaction rates.