bluuebunny/crossref_metadata_2025_split huggingface dataset:
Severe Recalled Labor Pain and Elective Cesarean Section in a Subsequent Delivery: A Cohort Study of Norwegian Parous Women
Authors: Junge C. , von Soest T. , Seidler A. , Eberhard-Gran M. , Garthus-Niegel S. 
Published: September 2022

(Acta Obstet Gynecol Scand. 2021;100:1678–1687)
Although the pain experienced in labor is quickly forgotten by most women, some with negative childbirth experiences may recall intense labor pain years later. These women may experience postpartum anxiety which can have a negative impact on the women and their ability to tend to their newborns. This can also affect other childbearing decisions including increased spacing between pregnancies, a reduced number of children, and an increased request for elective cesarean delivery (CD) in subsequent pregnancies. The rate of CD in Norway has risen by 13.3% from 1972 despite the WHO CD recommendation of a 10% to 15% CD rate together with evidence that there is no reduction in maternal or child mortality if the CD rate is >10%. With patient-requested CD increasing, the authors from Norway investigated whether a patient’s recall of labor pain from a previous vaginal delivery (VD) influenced their preference for their future mode of delivery. In addition, potential confounders such as maternal demographic, somatic and mental health factors were also evaluated in case these may have influenced such an association.
A Randomized Double-blind Comparison of Phenylephrine and Norepinephrine for the Management of Postspinal Hypotension in Pre-eclamptic Patients Undergoing Cesarean Section
Authors: Mohta M.R.L. , Chilkoti G.T. , Agarwal R. , Malhotra R.K. 
Published: September 2022

(Eur J Anaesthesiol. 2021;38:1077–1084)
Phenylephrine is the vasopressor of choice during cesarean delivery (CD) with spinal anesthesia; however, it can cause reflex bradycardia. Norepinephrine is being investigated as an alternative due to its ability to maintain better blood pressure (BP), heart rate, and cardiac output compared with phenylephrine while still seeing similar neonatal outcomes. Studies involving pre-eclamptic women need to be conducted to determine norepinephrine’s effectiveness in this population. This study aimed to compare bolus doses of norepinephrine and phenylephrine for postspinal hypotension in pre-eclamptic women undergoing CD.
Association Between Hyperbaric Bupivacaine Dose and Maternal Hypotension: Retrospective Database Study of 8226 Women Undergoing Cesarean Delivery Under Spinal Anesthesia
Authors: Weiniger C.F. , Heesen M. , Knigin D. , Deutsch F. , Hilber N. , Avidan A. 
Published: September 2022

(Anesth Analg. 2021;133:967–975)
Maternal hypotension is common following an intrathecal hyperbaric bupivacaine dose for cesarean delivery. Studies have varied results or insufficient data when investigating the optimal dose of hyperbaric bupivacaine to reduce the incidence of hypotension. The aim of the study was to determine the relationship between hyperbaric bupivacaine dose and spinal-induced maternal hypotension for women undergoing cesarean delivery.
The Effects of Exercise Programs on Exercise Capacity and Quality of Life in Patients Who Have Undergone Non-Small Cell Lung Cancer Treatment: A Systematic Review
Authors: Pruchnicki Michaela L. , Sullivan Glenney Susan 
Published: September 2022

Background:
Research has shown that individuals diagnosed with lung cancer suffer from decreased exercise capacity and health-related quality of life. There is a need to determine the effect of specific exercise intervention on exercise capacity and health-related quality of life in the non–small cell lung cancer population in order for exercise to be incorporated into the standard of care.

Purpose:
The purpose of this systematic review was to determine the effects of exercise training on exercise capacity and quality of life in patients who have undergone treatment for non–small cell lung cancer.

Methods:
Three databases were searched for articles that met the inclusion criteria. The search resulted in a total of 332 articles with 16 that met the criteria for inclusion.

Results:
Eight of the 16 studies showed significant improvement in exercise capacity and 4 showed significant improvement in quality of life with exercise training.

Discussion and Limitations:
This review provided limited evidence that exercise training in addition to usual care will provide improvement in overall exercise capacity and quality of life in this population. Limitations included reports of small sample size in the articles included, few databases searched, and heterogeneity of exercise programs.

Conclusions:
This systematic review supports exercise training as a method for improving exercise capacity and health-related quality of life in patients who have been diagnosed with non–small cell lung cancer. Further research must be done with more subjects and exercise protocols to make specific recommendations for exercise training in this population.
Patient-Reported Pain and Function Outcomes in Children With Congenital Vertical Talus Treated With the Minimally Invasive Method
Authors: Cummings Jason L. , Hosseinzadeh Pooya 
Published: September 2022

Background:
In 2006, a new minimally invasive method was introduced for the definitive correction of congenital vertical talus (CVT) deformity. There are no studies to date that have utilized the Patient-Reported Outcome Measurement Information System (PROMIS) to evaluate long-term quality of life outcomes in these patients.

Methods:
We identified all children with CVT who underwent treatment with the minimally invasive method and were seen at our institution after 2015. A retrospective chart review was then performed on these patients, and PROMIS scores were recorded for the following domains: Pain Interference, Mobility, and Peer Relations. Subgroup analysis was performed on patients who experienced recurrence and those who required a second corrective surgery. An alpha level of 0.05 was used for all analyses.

Results:
There were 24 children who were treated for CVT at our institution after 2015 and had completed PROMIS surveys. Seven (29.2%) of these patients developed recurrence during the follow-up period. Among the entire cohort, the mean PROMIS pain interference score was 48±9, the mean PROMIS mobility score was 42±13, and the mean PROMIS peer relations score was 54±9. There were no statistically significant differences in the PROMIS scores between the entire cohort and those who experienced radiographic recurrence in any of the 3 domains (P>0.05). Children who initiated treatment after the age of 12 months had lower PROMIS mobility scores than those who initiated treatment before 12 months of age (32.48 vs. 47.31, P=0.02).

Conclusion:
On average, children who undergo treatment with this technique end up within 1 SD of the reference population in all 3 domains that were measured (pain interference, mobility, and peer relations) regardless of sex, age, and status of recurrence. However, there was a trend towards lower mobility scores in this population compared with the reference population (42±13 vs. 50±10). Treatment should be initiated at less than 12 months of age whenever possible to maximize patient-reported outcomes.

Level of Evidence:
Level III.
Effects of postsystolic shortening and diastolic dyssynchrony on myocardial work in untreated early hypertension patients
Authors: Tsai Huey-Ru , Hsu Han-Chung , Wu Chun-I , Lee Wen-Huang , Tsai Wei-Chuan 
Published: September 2022

Objectives:
Myocardial work is estimated from noninvasive pressure-strain loop for advanced assessment of left ventricular function. Postsystolic shortening and diastolic dyssynchrony of left ventricle were noted early in hypertension. Their novel effects on myocardial work will be illustrated in this study.

Methods:
We recruited 43 newly diagnosed hypertensive patients (mean age 51.3 ± 12.5 years, 55.8% men) and 32 age-matched and sex-matched healthy individuals (mean age 52.7 ± 10.5 years, 37.5% men) as control. Pressure-strain loop derived myocardial work incorporated global longitudinal strain from speckle tracking echocardiography with brachial artery cuff pressure. Postsystolic strain index (PSI) was defined by the percentage of postsystolic shortening over peak strain. Diastolic dyssynchrony was assessed by standard deviation of time to peak early diastolic strain rate (TDSr-SD) of 18 segments, and maximal difference of time to peak early diastolic strain rate (TDSr-MD) between any two segments.

Results:
After multivariate regression analysis, global myocardial work index (GWI) was independently correlated with TDSr-SD (B = −0.498, P = 0.001) and TDSr-MD (B = −0.513, P = 0.001). Global myocardial constructive work (GCW) was independently correlated with TDSr-SD (B = −0.334, P = 0.025) and TDSr-MD (B = −0.397, P = 0.007). Global myocardial wasted work (GWW) was independently correlated with PSI (B = 0.358, P = 0.019). Global myocardial work efficiency (GWE) was lower in hypertensive patients than healthy control (P = 0.001). The untreated hypertensive patients were different from the healthy individuals with higher TDSr-SD, TDSr-MD, GWI, GCW, GWW, and PSI (all P < 0.05).

Conclusion:
In conclusion, the effect of diastolic dyssynchrony mainly influenced constructive work, whereas postsystolic shortening affected wasted work in early untreated hypertension.
Biomarker screening in preeclampsia: an RNA-sequencing approach based on data from multiple studies
Authors: Rezk Marlene , Grasegger Linda , Brandstetter Nina , Pol-Edern Le Renard , Stelzl Patrick , Oppelt Peter , Arbeithuber Barbara 
Published: September 2022

Objective:
Biomarkers have become important in the prognosis and diagnosis of various diseases. High-throughput methods, such as RNA sequencing facilitate the detection of differentially expressed genes (DEGs), hence potential biomarker candidates. Individual studies suggest long lists of DEGs, hampering the identification of clinically relevant ones. Concerning preeclampsia – a major obstetric burden with high risk for adverse maternal and/or neonatal outcomes – limitations in diagnosis and prediction are still important issues. We, therefore, developed a workflow to facilitate the screening for biomarkers.

Methods:
On the basis of the tool DESeq2, a comprehensive workflow for identifying DEGs was established, analyzing data from several publicly available RNA-sequencing studies. We applied it to four RNA-sequencing datasets (one blood, three placenta) analyzing patients with preeclampsia and normotensive controls. We compared our results with other published approaches and evaluated their performance.

Results:
We identified 110 genes that are dysregulated in preeclampsia, observed in at least three of the studies analyzed, six even in all four studies. These included FLT-1, TREM-1, and FN1, which either represent established biomarkers at protein level, or promising candidates based on recent studies. For comparison, using a published meta-analysis approach, 5240 DEGs were obtained.

Conclusion:
This study presents a data analysis workflow for preeclampsia biomarker screening, capable of identifying promising biomarker candidates, while drastically reducing the numbers of candidates. Moreover, we were also able to confirm its performance for heart failure. This approach can be applied to additional diseases for biomarker identification, and the set of DEGs identified in preeclampsia represents a resource for further studies.
Comparison between cuff-based and invasive systolic blood pressure amplification
Authors: Bui Tan V. , Picone Dean S. , Schultz Martin G. , Armstrong Matthew K. , Peng Xiaoqing , Black J. Andrew , Dwyer Nathan , Roberts-Thomson Philip , Adams Heath , Hughes Alun D. , Sharman James E. 
Published: September 2022

Objective:
Accurate measurement of central blood pressure (BP) using upper arm cuff-based methods is associated with several factors, including determining the level of systolic BP (SBP) amplification. This study aimed to determine the agreement between cuff-based and invasively measured SBP amplification.

Methods:
Patients undergoing coronary angiography had invasive SBP amplification (brachial SBP – central SBP) measured simultaneously with cuff-based SBP amplification using a commercially available central BP device (device 1: Sphygmocor Xcel; n = 171, 70% men, 60 ± 10 years) and a now superseded model of a central BP device (device 2: Uscom BP+; n = 52, 83% men, 62 ± 10 years).

Results:
Mean difference (±2SD, limits of agreement) between cuff-based and invasive SBP amplification was 4 mmHg (−12, +20 mmHg, P < 0.001) for device 1 and −2 mmHg (−14, +10 mmHg, P = 0.10) for device 2. Both devices systematically overestimated SBP amplification at lower levels and underestimated at higher levels of invasive SBP amplification, but with stronger bias for device 1 (r = −0.68 vs. r = −0.52; Z = 2.72; P = 0.008). Concordance of cuff-based and invasive SBP amplification across quartiles of invasive SBP amplification was low, particularly in the lowest and highest quartiles. The root mean square errors from regression between cuff-based central SBP and brachial SBP were significantly lower (indicating less variability) than from invasive regression models (P < 0.001).

Conclusions:
Irrespective of the difference from invasive measurements, cuff-based estimates of SBP amplification showed evidence of proportional systematic bias and had less individual variability. These observations could provide insights on how to improve the performance of cuff-based central BP.
Efficacy of Liriope platyphylla extract on improving respiratory function: A CONSORT-randomized, double-blind, placebo-controlled pilot trial
Authors: Won Eun Sol , Ku Yong Ho , Lee Eun Yi , Kim Il-Woung , Lee Hyun , Kang Jae Hui 
Published: September 2022

Background:
The respiratory system is the first line of defense against outside pollutants. Recently, respiratory health has been receiving increasing attention due to the increase in fine dust, which reduces respiratory function and increases incidence of chronic obstructive pulmonary disease, and in coronavirus pandemic, which can cause severe acute respiratory syndrome.

Methods:
This clinical pilot trial was designed to secure evidence for a main clinical trial and to confirm the efficacy and safety of Liriope platyphylla (LP) extract for improving respiratory function. We conducted a double-blind randomized placebo-controlled trial with 22 participants from June 30, 2021, to August 25, 2021. The primary outcome was Breathlessness, Cough, and Sputum Scale score. Secondary outcomes included forced vital capacity, forced expiratory volume at 1 second (FEV1), forced expiratory volume at 1 s/forced vital capacity ratio, cough assessment test score, chronic obstructive pulmonary disease assessment test score, peripheral blood mononuclear cell counts (white blood cells, eosinophils, T cells, and B cells), high-sensitivity C-reactive protein level, erythrocyte sedimentation rate, cytokine (interleukin-1β, interleukin-4, tumor necrosis factor-α, interleukin-6, interleukin-8, interferon-γ, and immunoglobulin E) levels, antioxidant (glutathione peroxidase and superoxide dismutase) levels, and nitric oxide level.

Results:
A total of 22 participants were randomly assigned to 2 groups: the LP group (n = 11), who took 1000 mg of LP extract per day, and the placebo group, who took 1000 mg of dextrin per day. Participants took 1 capsule twice a day for 4 weeks. For the Breathlessness, Cough, and Sputum Scale, the interaction between group and visit was statistically significant in a blend of analyses of variance. interleukin-8, tumor necrosis factor-α, and interferon-γ levels decreased more in the LP group than in the placebo group. The sample size required for large-scale clinical trials in the future was 50. There were no side effects.

Conclusion:
LP extract can enhance respiratory function. The detailed data we obtained support conducting the future main large-scale clinical trial.
Molecular mechanism of Sishen pills in the treatment of diarrheal diabetic enteropathy based on network pharmacology
Authors: Tao Yunxia , Li Chongchai , Gao Tianshu , Huo Jingjing 
Published: September 2022

This study aimed to explore the effectiveness and safety of Sishen pills for the treatment of diarrheal diabetic enteropathy (DDE).
The Traditional Chinese Medicine (TCM) Systems Pharmacology and BATMAN-TCM databases were used to determine the chemical composition of Sishen pills and thus predict information on protein targets. We searched for potential targets of DDE in the GeneCards, DrugBank, Therapeutic Target (TTD), and DisGeNET databases. Using the intersection of the drug and disease targets, protein–protein interaction (PPI) networks and molecular interaction modules were constructed, and key targets were screened. The intersecting gene targets were imported into the Metascape database to conduct Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses. The core targets and active ingredients were then docked at the molecular level.
Sishen pills contain 70 active ingredients, 463 targets, and 566 disease targets. A module analysis of the targets revealed that the module was mainly related to adrenergic receptor activity, the adenosine phosphate kinase signaling pathway, and the G protein-coupled receptor signaling pathway. The GO and KEGG pathway enrichment results indicated that the protein genes regulated by Sishen pills were mainly enriched in the response to lipopolysaccharides, the AMPK signaling pathway, the JAK-STAT signaling pathway, and other signaling pathways. The molecular docking results showed that the core active compounds exhibited good binding activity with the predicted targets.
Sishen pills can regulate the immune function of the body through anti-inflammatory and antibacterial effects for the treatment of DDE.
Comparing the effects of continuous infusion of esmolol and ramosetron alone and in combination on nausea and vomiting after laparoscopic cholecystectomy: A prospective, randomized, double-blind study
Authors: Ji Jae Young , Kim Nan Seol , Seo Yong Han , Jung Ho Soon , Chun Hea Rim , Park Jin Soo , Choi Jeong Soo , Ahn Jae Min , Kim Woo Jong 
Published: September 2022

Background:
Postoperative nausea and vomiting (PONV) is a common complication of laparoscopic cholecystectomy. Although PONV is usually mild, severe thing can delay recovery and prolong hospitalization. We aimed to investigate the effects of ramosetron and esmolol, alone and in combination, on PONV, and pain.

Methods:
We enrolled 165 patients in their 20s to 50s who had an American Society of Anesthesiology physical status score of 1 or 2 and were scheduled to undergo laparoscopic cholecystectomy. They were randomly allocated into 3 groups: groups R, E, and E+R. Patients in group R received 0.3 mg of ramosetron following surgery. Those in group E were intravenously administered a bolus of esmolol (1.0 mg/kg) before endotracheal intubation. They were continuously infused with esmolol during the surgery to maintain their heart rate at 60 to 100 beats per minute and mean blood pressure at 60 to 100 mm Hg, followed by a bolus of esmolol (1.0 mg/kg) following surgery. Patients in group E+R were intravenously administered a bolus of esmolol (1.0 mg/kg) before endotracheal intubation, infused esmolol during surgery, and administered 0.3 mg of ramosetron and a bolus of esmolol (1.0 mg/kg) following surgery. We monitored the PONV stages (none, nausea, retching, and vomiting) and symptom severity in 3 postoperative stages (0–30 minutes, 30 minutes to 6 hours, and 6–24 hours), the latter by using the visual analog scale (VAS). We conducted an analysis of variance to compare VAS scores between groups.

Results:
Patients in groups E (mean ± standard deviation VAS score, 3.62 ± 1.00) and E+R (3.66 ± 0.71) exhibited less pain (P < .05) until 30 minutes following surgery compared to group R (5.72 ± 1.41). More patients in group E (28/50, 56%) experienced nausea compared to those in groups R (15/50, 30%) and E+R (8/50, 16%) until 30 minutes after surgery (P < .05). However, there were no differences in the severity of retching and vomiting between the groups in any of the phases (P > .05).

Conclusion:
Despite reducing pain after laparoscopic cholecystectomy, esmolol did not prevent PONV, whether used alone or in combination with ramosetron.
Effects on venous flow of transcutaneous electrical stimulation, neuromuscular stimulation, and sham stimulation on soleus muscle: A randomized crossover study in healthy subjects
Authors: Senin-Camargo Francisco , Martínez-Rodríguez Alicia , Chouza-Insua Marcelo , Raposo-Vidal Isabel , Jácome M. Amalia 
Published: September 2022

Background:
Activation of venous flow has been shown with different types of electrical stimulation. The aim of this study is to compare the hemodynamic effects of transcutaneous electrical nerve stimulation (TENS), neuromuscular electrical stimulation (NMES), and sham stimulation on healthy young people.

Methods:
This randomized crossover study was conducted during June 2018 in the Faculty of Physical Therapy of A Coruña (Spain). Twenty-four university students (50% male) received in a randomized order 5 Hz-TENS, NMES, and sham stimulation on soleus muscle. Flow volume (FV) and peak velocity (PV) from popliteal vein were recorded via Doppler ultrasound, and relative changes from baseline were determined. Discomfort among the 3 stimulations was also compared.

Results:
The differences among the 3 stimulations were assessed using the ANOVA for repeated measured, the Friedman test and the Kendall tau test, according to the type of measurement to be compared. FV (mL/min) and PV (cm/s) increased significantly after NMES (percentual increase 37.2 ± 62.0%, P = .002; 264.4 ± 152.2%, P < .001, respectively) and TENS (226.2 ± 190.3%, P < .001; 202.7 ± 144.6%, P < .001, respectively). These percentual changes from basal level in hemodynamics were statistically different to those after placebo, which was ineffective enhancing hemodynamics. The improvements in FV were statistically higher with TENS than with NMES (P < .001), but there was no statistical difference in PV (P = .531). Despite NMES was applied at a significantly lower amplitude than TENS (P < .001), NMES protocol was the worst tolerated, though the differences in discomfort were not statistically significant.

Conclusion:
Both active electrical protocols but not sham stimulation increased hemodynamics in healthy people. TENS obtained higher flow volume increase from baseline than NMES, considered globally at not only in its on-time.