bluuebunny/crossref_metadata_2025_split huggingface dataset:
Safety of robot-assisted radical prostatectomy in an Italian spoke hospital: Long-term oncologic and functional outcomes with median 11.3 years follow-up
Authors: Fulcoli Vittorio , Bianco Marta , Sartor Gino , Agostini Andrea , Costa Giuseppe , Laurini Lucio 
Published: February 2022

Introduction: Robot-assisted radical prostatectomy (RARP) long-term oncologic outcomes were published in few studies. This paper provides a complete overview of RARP long-term oncologic and functional results produced in an Italian spoke hospital. Methods: From December 2004 to December 2010, 300 consecutive patients with prostate cancer were treated with extraperitoneal RARP. Biochemical recurrence-free survival (BCRFS), salvage therapy-free survival (STFS), prostate cancer specific survival (PCa-SS), and overall survival (OS) were estimated using the Kaplan–Meier analysis and log-rank test. Cox proportional hazard regression analysis was performed to identify predictors of BCR and ST. Crude rates of continence and potency recovery after surgery were reported. Results: Median follow-up was 135.6 months (IQR 20–184). At 15 years, BCR-FS, ST-FS, PCa-SS, and OS rates were 78% (95% CI 0.73–0.83), 85% (95% CI 0.81 −0.89), 98% (95% CI 0.97–100), and 89% (95% CI 0.84–0.94), respectively. On multivariate analysis, biopsy ISUP grade ⩾2, clinical stage ⩾pT3a, D’Amico high-risk patients subgroup, pathologic ISUP grade ⩾2, and multifocal/extensive positive margins were independent predictors of BCR. The same risk factors plus D’Amico intermediate risk patients subgroup were independent predictors of ST. After surgery, 280 (93.3%) and 93 (35.2%) patients experienced continence and potency recovery, respectively. The retrospective nature of the analysis and some selection biases represent the principal limitations of the study. Conclusion: The results showed in the present study match those obtained in referral centers and this is an evidence against the general belief that best prostate cancer care in provided in high volume hospitals and against centralization. Adverse characteristics of the tumor remain the best predictors of BCR and ST.
Suicidal Ideation and Mental Health Help-Seeking Behaviors Among Older Chinese Adults During the COVID-19 Pandemic
Authors: Liang Ying-Jie , Deng Fang , Liang Pengwei , Zhong Bao-Liang 
Published: February 2022

Objective To examine prevalence and correlates of suicidal ideation in older Chinese adults (OCAs) during the COVID-19 pandemic, as well as mental health help-seeking behaviors of suicidal OCAs. Background Few data on suicidal behaviors of older adults during the pandemic are available. Methods In this cross-sectional survey, 1159 OCAs completed an online self-administered questionnaire between 23 February and 25 March 2020. A standardized single question and the 12-item General Health Questionnaire were used to assess the presence of suicidal ideation and common mental health problems (CMHPs), respectively. Suicidal ideators were further asked about their perceived need for mental health care and help-seeking from mental health workers. Results 4.1% of the OCAs experienced suicidal ideation during the past 2 weeks. Among the suicidal OCAs, 31.9% perceived a need for mental health care but only 10.6% had sought help from mental health workers. Factors significantly associated with suicidal ideation were a marital status of “others” (OR=2.39, P = .021), disagreement regarding the successful containment of the pandemic (OR=2.43, P = .022), physical health problems (OR=2.23, P = .012), and CMHPs (OR=4.99, P < .001). Conclusions During the COVID-19 pandemic, OCAs constitute a subpopulation that needs mental health services for suicidal problems but tends not to seek mental health help. Mental health services for OCAs may include mental health education, periodic evaluation of risk of suicide, expanded psychosocial support, and, when necessary, psychological crisis intervention and psychiatric treatment.
Determinants of Commute Time in an Indian City
Authors: Sridhar Kala Seetharam , Nayka Shivakumar 
Published: February 2022

Given the conspicuous lack of adequate research on commute time in the Indian intra-urban context, the research questions we answer in this article are: what is the average commute time to work for residents? What does this imply for the city’s effective labour market? What are the determinants of commute time to work? This article studies the questions for a large Indian city, known for its traffic gridlocks. Given that published data on journey-to-work is not readily available for Indian cities, we report findings from primary surveys of commuters travelling to work in Bengaluru. The actual time taken by commuters to reach their workplace is 42.45 minutes one-way, implying an insignificant reduction in the city’s effective labour market since 2001. We use geographic information systems to map the sectoral flow of workers and their origins and destinations within the city. Estimating regressions of the determinants of commute time, we find that workers in government jobs travel longer to get to work, elevation has a negative effect on commute time, and commute distance positively impacts travel time. The contribution of the article is the report of an Indian city’s commute time and its determinants, which can be used to influence policy. JEL Classification: R12, R41, R42
Platelet-Rich Plasma (PRP) to promote corneal healing in firework-related ocular burn and total limbal stem cell deficiency (LSCD)
Authors: Mallone Fabiana , Marenco Marco , Giustolisi Rosalia , Plateroti Rocco , Lambiase Alessandro 
Published: February 2022

Purpose To report the case of persistent corneal epithelial defect in total limbal stem cell deficiency (LSCD) after severe firework-related ocular burn treated with autologous Platelet-Rich Plasma (PRP). Case description A young patient, victim of fireworks trauma, presented with a large persistent epithelial defect affecting the central cornea of his left eye and progressing to stromal melting, in the context of grade VI ocular surface burn with 12 h limbal involvement. Impression cytology to the cornea confirmed a complete LSCD. Assessment of corneal sensitivity by Cochet Bonnet esthesiometer revealed complete corneal anesthesia. Based on progressive clinical worsening under conventional therapy, the patient was started on very pure autologous PRP eye drops obtained using the Hy-Tissue PRP® technology. Six times a day eye drops administration for 30 days was scheduled in the affected eye. At the end of treatment, the epithelial defect had disappeared being replaced by advancing conjunctiva. Conclusion Our findings provide information on management of ocular burns from fireworks, a subject of current interest and concern. Autologous PRP eye drops prepared using the Hy-Tissue PRP® system and administered in the presence of total LSCD and complete corneal anesthesia, prevented corneal stromal melting to progress and allowed the ocular surface epithelial coverage to re-establish. This paved the way for later successful restorative and reconstructive intervention. Also, first description of the Hy-tissue PRP procedure for ophthalmological use is reported.
Novel Self-expanding Shape-Memory Bioresorbable Peripheral Stent Displays Efficient Delivery, Accelerated Resorption, and Low Luminal Loss in a Porcine Model
Authors: Glushchenko Leonid , Hubbard Brad , Sedush Nikita , Shchepochkin Vladislav , Krupnin Artur , Sharafeev Aidar 
Published: February 2022

Objective and Design: The search for improved stenting technologies to treat peripheral artery disease is trending toward biodegradable self-expanding shape-memory stents that, as of now, still suffer from the acute trade-off between deliverability and luminal stability: Higher deliverability leads to lower lumen stability, vessel recoil, and stent breakage. This study was aimed at the development and testing of a self-expanding bioresorbable poly(l,l-lactide-co-ε-caprolactone) stent that was designed to produce confident self-expansion after efficient crimping, as well as quick bioresorption, and sufficient radial force. Materials and Methods: Bench tests were employed to measure shape-memory properties, radial force, and hydrolytic degradation of the stent. The porcine model was employed to study deliverability, lumen stability, biocompatibility, and stent integrity. A total of 32 stents were implanted in the iliac arteries of 16 pigs with 15 to 180 day follow-up periods. The stented vessels were studied by angiography and histological evaluation. Results: Recovery of the diameter of the stent due to shape-memory effect was equal to 90.6% after 6Fr crimping and storage in refrigeration for 1 week. Radial force measured after storage was equal to 0.7 N/mm. Technical success of implantation in pigs (after the delivery implemented by pusher) was 94%. At 180 days, no implanted stents were found to be fragmented: All of the devices remained at the site of implantation with no stent migration and all stents retained their luminal support. Only moderate inflammation and neoepithelialization were detected by histological assessment at 60, 90, 120, and 180 days. Lumen loss at 180 days was less than 25% of the vessel diameter. Conclusions: The stent with the mechanical and chemical properties described in this study may present the optimal solution of the trade-off between deliverability and luminal stability that is necessary for designing the next generation stent for endovascular therapy of peripheral arterial disease.
Past, Present and Future: Perspectives on an Oral History of Intellectual Disability Nursing
Authors: Doyle Carmel , Griffiths Colin , McAnelly Su , Atherton Helen , Cleary Michelle , Fleming Sandra , Gates Bob , Keenan Paul , Sutton Paul 
Published: February 2022

Thirty-one participants engaged in this oral history research study aimed at exploring the lived experience of intellectual disability nurses and healthcare assistants’ knowledge of the trajectory of intellectual disability nursing over the last 30 years in the Republic of Ireland and England. This paper documents some of these experiences offering perspectives on intellectual disability nursing and what is important for the future. Findings from Ireland consider the nature of intellectual disability services and the registered nurse in intellectual disability. Findings from England focus on opportunities and restrictions in intellectual disability nursing, shared visions, the changing context within which work took place and also the internal and external supports that impacted their roles. It is evident that intellectual disability nurses must be responsive to the changing landscape of service provision and also the requirements for contemporary new roles to meet the changing needs of people with intellectual disabilities.
Social Justice Education in Dentistry: A Qualitative Analysis and Conceptual Framework
Authors: Kontaxis K.L. , Esfandiari S. 
Published: February 2022

Background: Social justice, empathy, and social responsibility are emerging themes in dentistry. Many dental faculties have started incorporating these concepts into their curriculum, but our knowledge of the effectiveness of these initiatives remains limited. Purpose: The objective of this study was to understand how students and educators perceive the role of social justice education, if any, in the undergraduate dentistry program. Methods: This qualitative study was performed by using semistructured interviews with students, professors, and clinical faculty at the Université de Montréal dental school from January to May 2020. Eighteen participants were recruited through purposeful sampling until saturation. The interviews were recorded and transcribed integrally. They were coded with QDA Miner 5.0 (Provalis). Thematic analysis was undertaken to elucidate emerging themes via qualitative methodology. Results: Five themes emerged from the results. Certain students were more inclined to be interested in social justice and participate in voluntary community-based activities. There were gaps in current teaching methods, including a lack of exposure to alternative treatment plans (e.g., extractions vs. endodontic treatments) better suited to patients’ financial or social situations. Some barriers to teaching were identified, the most important being a lack of time. Desired teaching of social justice would include increased awareness and active student participation and taking responsibility to motivate action to produce social change. The application of social justice in dentistry involves care that is accessible and adapted to a patient’s individual needs. Conclusion: The results of this study provide valuable insight for the development of a social justice education curriculum in dentistry that can be evaluated and validated to train socially competent dentists who can provide patient-centered care to the community. Knowledge Transfer Statement: The results of this study can be used by dental educators and administrators who are looking to incorporate social justice education into their dental school undergraduate curriculum. The findings serve as a starting point to foster discussions and inspire change to reduce inequalities within the dental health care system.
Association of Race, Ethnicity, and Socioeconomic Status With Esthesioneuroblastoma Presentation, Treatment, and Survival
Authors: Sharma Rahul K. , Irace Alexandria L. , Overdevest Jonathan B. , Turner Justin H. , Patel Zara M. , Gudis David A. 
Published: February 2022

ObjectiveSocioeconomic and other demographic factors are associated with outcomes in head and neck cancer. This study uses a national cancer database to explore how patient race, ethnicity, and socioeconomic status (SES) are associated with esthesioneuroblastoma outcomes, including 5‐year disease‐specific survival (DSS), conditional DSS, stage at diagnosis, and treatment.Study DesignRetrospective cohort analysis.SettingPatients with esthesioneuroblastomas between 1973 and 2015 from the SEER registry (Surveillance, Epidemiology, and End Results).MethodsThe National Cancer Institute Yost Index, a census tract–level composite score composed of 7 parameters, was used to categorize the SES of patients. Kaplan‐Meier analysis and Cox regression were conducted to assess DSS. Conditional DSS was calculated per estimates from simplified Cox models. Logistic regression was conducted to identify risk factors for advanced cancer stage at diagnosis and the likelihood of receiving multimodal therapy.ResultsComplete data were included for 561 patients. DSS was significantly associated with SES (log‐rank, P <. 01) but not race. According to Cox regression, DSS was worse for the lowest SES tertile vs the highest (hazard ratio, 1.70 [95% CI, 1.05‐2.75]; P =. 03). Patients of the lowest SES tertile exhibited an increased risk of advanced cancer stage at diagnosis as compared with the highest SES tertile (odds ratio, 1.84 [95% CI, 1.06‐3.30]; P =. 035). Black patients (odds ratio, 0.44 [95% CI, 0.24‐0.84]; P =. 011) were less likely than other patients to receive multimodal therapy. SES alone was not associated with receiving multimodal therapy.ConclusionSES is significantly associated with DSS and conditional DSS for patients with esthesioneuroblastomas. Inequalities in access to care and treatment likely contribute to these disparities.
Limited Open Achilles Repair Without Instrument-Guided Assistance
Authors: Chopra Aman , Parekh Aarav S. , Parekh Selene G. 
Published: February 2022

Background: The limited open Achilles tendon repair technique has recently gained popularity as a treatment option for acute Achilles tendon ruptures. This surgical technique video describes a limited open Achilles tendon repair without instrument guided assistance, demonstrating improved clinical outcomes for patients while also reducing reliance on operative equipment, cost, and the duration of surgery. Indications: The indications for this limited open Achilles tendon repair technique include an Achilles tendon rupture less than 6 weeks from injury occurring in the watershed area. Technique Description: The patient is prone and a 2- to 3-centimeter longitudinal incision is made over the Achilles tear. In the proximal stump, 3 nonabsorbable sutures are passed horizontally from proximal to distal direction. In the distal stump, the same is done in a nonlocking manner. The stumps are then reflected and the deep fascial compartment is released. The foot is plantarflexed to reduce tension on the repair site. The nonlocking sutures are tied sequentially from distal-distal to proximal-proximal direction. A running box suture using a nonabsorbable suture followed by 0-Vicryl around the rupture site is performed. Results: This technique has demonstrated, at a median follow-up of 3.7 years, restored pre-injury function along with no wound complications, re-ruptures, or re-operations in 33 patients. The median time from injury to surgery was 10 (range, 1-45) days and the mean time for returning to pre-injury level of activity was 5.6 (range, 1.7-22.1) months. After the procedure, patients demonstrated significant improvements in mean Foot and Ankle Disability Index (49.1-98.4), mean Visual Analog Scale pain score (4.8-0.2), and mean Foot and Ankle Outcome Score (FAOS) subscales such as FAOS pain (54.8-99.2), FAOS symptoms (84.6-97.0), FAOS activities of daily living (61.4-97.2), FAOS sports and recreational activity (39.5-98.5), and FAOS quality of life (39.7-88.7). Conclusion: Patients who underwent a limited open Achilles tendon repair without instrument-guided assistance demonstrated significant improvements in outcome scores with minimal complications.
Circulating tumor DNA predicts therapeutic outcome in mantle cell lymphoma
Authors: Lakhotia Rahul , Melani Christopher , Dunleavy Kieron , Pittaluga Stefania , Saba Nakhle , Lindenberg Liza , Mena Esther , Bergvall Ethan , Lucas Andrea Nicole , Jacob Allison , Yusko Erik , Steinberg Seth M. , Jaffe Elaine S. , Wiestner Adrian , Wilson Wyndham H. , Roschewski Mark 
Published: February 2022

Abstract
Mantle cell lymphoma (MCL) is biologically and clinically heterogeneous and would benefit from prognostic biomarkers to guide management. Circulating tumor DNA (ctDNA) is a novel prognostic biomarker in diffuse large B-cell lymphoma that may have applicability in MCL. We analyzed ctDNA dynamics in previously untreated patients with MCL who received induction therapy with bortezomib and DA-EPOCH-R for 6 cycles followed by random assignment to observation or bortezomib maintenance in responding patients in a prospective phase 2 study. Most patients also underwent initial treatment window of bortezomib alone prior to induction. Serum was collected pretreatment, after the window, after cycles 1 and 2, at the end of induction, and at each follow-up visit along with restaging computed tomography scans. Next-generation sequencing was used to identify and quantify ctDNA encoding the immunoglobulin receptor sequences in serum as markers of minimal residual disease. Fifty-three patients were enrolled, with a median follow-up of 12.7 years. Patients without detectable ctDNA after 2 cycles of induction had longer progression-free survival (PFS) and overall survival (OS) compared with those with detectable ctDNA (median PFS, 2.7 vs 1.8 years; overall P = .005; median OS, 13.8 vs 7.4 years; overall P = .03). Notably, in vivo assessment of ctDNA dynamics during the bortezomib window was not prognostic, and there was no difference in PFS or OS with bortezomib maintenance. ctDNA monitoring after induction showed that molecular relapse preceded clinical relapse in some cases. In conclusion, interim ctDNA negativity strongly correlates with improved survival and supports the investigation of response-adapted strategies. This trial was registered at www.clinicaltrials.gov as #NCT00114738.
Are additional screws required for press-fit fixation of cementless acetabular cups? A systematic review and meta-analysis
Authors: Ni Shenghui , Luo Peng , Guo Lei , Jiang Tianlong 
Published: February 2022

Abstract
Background
Press-fit cementless acetabular cup is widely used in total hip arthroplasty (THA). However, the use of additional screws for the acetabular cup has been extensively debated. The purpose of this review is to compare the stability, revision rate, wear rate, and clinical scores of cementless acetabular cups with and without screws in THA.

Materials and Methods
Comprehensive literature searches of the following databases were performed: Cochrane Library, Pubmed, Web of Science, OVID, Elsevier ClinicalKey, Clinicaltrials.gov, and EMBASE. We searched for trials that compared cementless acetabular cups with screws or without screws, and were published in the English language. We evaluated the stability of the prosthesis by osteolysis and migration. The clinical scores included Harris hip scores (HHS) and pain scores.

Results
Nineteen articles involving 4046 THAs met the inclusion criteria. Our analysis revealed that additional screws did not increase the stability of acetabular cups, and there was no statistical significance between the groups with and without screws in osteolysis and clinically relevant migration. Revision rates showed no significant difference between the groups with and without screws. There was no difference in wear between the two groups. Our analysis showed no difference in pain scores and HHS between groups.

Conclusion
Press-fit without screws could achieve sufficient acetabular cup stability. Acetabular cups without screws showed no difference from acetabular cups with screws in many outcomes. Additional screws are not required for cementless acetabular cups.
Level of evidence: Level III.
Robust meta-analysis for large-scale genomic experiments based on an empirical approach
Authors: Sikdar Sinjini 
Published: February 2022

AbstractBackgroundRecent high-throughput technologies have opened avenues for simultaneous analyses of thousands of genes. With the availability of a multitude of public databases, one can easily access multiple genomic study results where each study comprises of significance testing results of thousands of genes. Researchers currently tend to combine this genomic information from these multiple studies in the form of a meta-analysis. As the number of genes involved is very large, the classical meta-analysis approaches need to be updated to acknowledge this large-scale aspect of the data.MethodsIn this article, we discuss how application of standard theoretical null distributional assumptions of the classical meta-analysis methods, such as Fisher’sp-value combination and Stouffer’s Z, can lead to incorrect significant testing results, and we propose a robust meta-analysis method that empirically modifies the individual test statistics andp-values before combining them.ResultsOur proposed meta-analysis method performs best in significance testing among several meta-analysis approaches, especially in presence of hidden confounders, as shown through a wide variety of simulation studies and real genomic data analysis.ConclusionThe proposed meta-analysis method produces superior meta-analysis results compared to the standardp-value combination approaches for large-scale simultaneous testing in genomic experiments. This is particularly useful in studies with large number of genes where the standard meta-analysis approaches can result in gross false discoveries due to the presence of unobserved confounding variables.