bluuebunny/crossref_metadata_2025_split huggingface dataset:
Synchronous glioblastoma and brain metastases: illustrative case
Authors: Shahsavari Nastaran , Ahmad Maleeha , Sekar Vashisht , Meola Antonio , Hancock Steven L. , Chang Steven D. , Chiang Veronica L. 
Published: March 2022

BACKGROUND
Radiosurgical treatment of brain metastases is usually performed without brain tissue confirmation. While it is extremely rare for glioblastoma to develop concurrently in patients with brain metastases, they can look radiographically similar, and recognition is important because it alters management and prognosis. The synchronous presence of brain metastases and glioblastoma has not been published to date in the literature, making this a rare illustrative case.

OBSERVATIONS
A 70-year-old female had lung biopsy-proven metastatic lung adenocarcinoma and multiple brain metastases. Her treatment course included initial carboplatin, pemetrexed, and bevacizumab followed by maintenance nivolumab, and she underwent stereotactic radiosurgery to the multiple brain metastases. During interval radiological surveillance, one lesion in the right temporal lobe was noted to slowly progress associated with development of significant perilesional edema causing midline shift despite repeated stereotactic radiosurgical treatments. Biopsy of this lesion revealed glioblastoma, IDH wildtype.

LESSONS
Glioblastomas and brain metastases have similar radiological features, so the possibility of incorrect diagnosis needs to be considered for all lesions with interval growth poststereotactic radiosurgery. Biopsy and/or resection/laser ablation should be considered prior to reirradiation.
Analisis Souvenir Di Langgam Batik & Souvenir Tembung Berbahan Kain Perca Ulos
Authors: Siallagan Nadya Rosa , Misgiya Misgiya , Kurni Azis Adek Cerah 
Published: March 2022

Penelitian ini bertujuan untuk menerapkan prinsip-prinsip kerajian dan variasi pada souvenir berbahan kain perca ulos, yang dilaksanakan di Usaha Langgam Batik & Souvenir di Jalan Pengapdian Gg. Musa Pulungan Dusun I Bandar setia, Tembung, Sumatera Utara.Penelitian ini merupakan penelitian deskriptif kualitatif.Sampel untuk penelitian ini 12 jenis souvenir berbahan kain perca ulos yang diproduksi pengrajin.Metode pengumpulan data yang digunakan adalah observasi dan dokumentasi.Hasil penelitian ini memperlihatkan hasil penerapan prinsip-prinsip kerajinan pada 12 sampel souvenir berbahan kain perca ulos yang diproduksi pengrajin.
PENGARUH BAURAN PROMOSI TERHADAP KEPUTUSAN PEMBELIAN (Studi Kasus pada Pemasaran Busana Muslim pada UKM Tamykalika di Masa Pandemi Covid-19)
Authors: Veranita Mira , Susilowati Rini , Ratna H Yunyun , Arisena Adri 
Published: March 2022

UKM Tamykalika sebagai produsen busana muslim, harus selalu dapat memenuhi keinginan masyarakat yang selalu berubah karena perubahan gaya hidup dan trend mode. Di masa pandemic Covid-19 ini, berbagai pembatasan diberlakukan oleh pemerintah untuk mencegah penyebaran virus Covid-19 yang pada akhirnya berdampak pada berbagai aktivitas ekonomi, termasuk UKM Tamykalika.
Penelitian ini bertujuan untuk mengetahui pengaruh bauran pemasaran terhadap keputusan pembelian, dengan menggunakan metode deskriptif kuantitatif, dengan alat pengumpulan data observasi, wawancara dan penyebaran kuesioner kepada 75 orang responden.
Hasil penelitian menunjukkan bahwa UKM Tamykalika beradaptasi dengan menerapkan online marketing dan melakukan promosi online melalui platform media sosial dan market place.
Koefisien determinasi menunjukan bahwa pengaruh bauran promosi terhadap proses keputusan pembelian busana muslim di UKM Tamykalika adalah sebesar 74,91%, sedangkan sisanya 25,09% ditentukan oleh faktor-fakror lain diluar penelitian seperti tingkat pendapatan, trend dan pesaing.
Stop bullying! Does gender influence bullying and bully victims?
Authors:   Universiti Utara Malaysia, Azid Nurulwahida , Nakman Siti Jaizah ,   SMK Taman Tun Aminah, Johor, Malaysia, Kiong Tee Tze ,   Universiti Tun Hussein Onn Malaysia, Heong Yee Mei ,   Universiti Tun Hussein Onn Malaysia
Published: March 2022

The problem and the aims of the study. Every student should not be afraid to go to school because of harassment and parents should not be worried that their children will be bullied while at school. This study aimed to examine whether gender influences Malaysian school students of being bullies or bully victims. Research methods. The design of a cross sectional survey using a questionnaire for the data collection process to identify the influence between the study variables was conducted. Dependent study variables consisted of bullies (physical, verbal, anti-social & cyber) and bully victims (physical, verbal, anti-social & cyber). While the independent variable was gender (male & female). A total of 700 samples were involved in this study consisting of students aged 13, 14 and 16 years (students aged 15 and 17 years were not involved in the study as they were national examination candidates). A set of questionnaires containing 61 items measuring four constructs of bullying (physical, verbal, anti-social & cyber) as well as 60 items measuring four constructs of bully victims. The sample consisted of 349 males (49.9%) and 351 females (50.1%). Results. Independent t-test analysis as a whole showed that there was a significant difference in the tendency to be a bully among students based on gender, t (689) = 2.69, p <.05. Data showed male students were more likely to be bullies than female students. The finding of an independent sample t-test showed that there was no significant difference in the tendency to be a bully victim among students based on gender t(689) = 1.23, p > .05. However, there was a tendency to become bully victims among students based on gender for the categories of physical bullying (p <.05, p = .000) and cyber bullying (p <.05, p = .015). In conclusion students' tendency to become bullies and bully victims can occur among male or female students. Every individual should have the right to be free from being oppressed or deliberately humiliated either in school or in society.
Validation of the Estimated Torques of an Open-chain Kinematic Model of the Human Body
Authors: Petró Bálint , Kiss Rita M. 
Published: March 2022

The standing human body is frequently modeled as an inverted double pendulum restricted to a single plane. In order to capture the coordination efforts and interplay between spatial dimensions, the model has to capture motion and joint torques in all spatial dimensions. Our two-segment model covers two degrees of freedom (ML and AP revolutions) at the ankle and the hip level and utilizes the Denavit-Hartenberg convention. This work aimed to validate the model's torque estimation on a diverse group of participants (11 women, 22–56 years, 11 men, 22–61 years). The inverse dynamic calculations provide estimated joint torques for a motion capture recorded trial, while standing on a force platform enables the indirect measurement of ankle torques. A 60-second-long visually guided balancing task was recorded and repeated three times. The estimated and the indirectly measured torques were compared, and offset and variance type errors ( normalized RMSE and R2 ) were analyzed. The R2-values were excellent (R2 > 0.90) 64 out of the 66 cases (97%) for AP torques and 58 out of the 66 cases (88%) for ML torques. Normalized RMSE values were dominantly under the 0.35 value with some outliers. RMSE showed no evident connection with age, body height, body mass, or BMI. An open-chain kinematic model with two segments, following the Denavit-Hartenberg convention, is well suited to estimate the control torque traces of the human body during standing balancing and needs only three tracked positions.
The Relationship Between Assessment Centre Outcomes and Personality Traits
Authors: Szabó Zsolt Péter , Simon Evelin , Pinczés Máté , Laczai Róbert , Kun Ágota 
Published: March 2022

The present study aimed to assess the nomological validity of the Assessment Centre (AC). More specifically, the authors investigated the relationship between theoretically related personality variables and AC ratings in a personnel selection procedure. Previous studies have reported contradictory findings regarding the nomological validity of the Assessment Centre. We identified shortcomings in the previous studies and demonstrated the nomological validity of the AC in a relatively large sample of line manager candidates (N = 314). Our results are in harmony with trait activation theory, and this confirms the nomological validity of Assessment Centres. The theoretical and practical implications of these findings are discussed.
PENGARUH PENDIDIKAN KESEHATAN METODE DEMONSTRASI TERHADAP HAND HYGIENE 6 LANGKAH 5 MOMEN KELUARGA PASIEN
Authors: Rosidah Binti 
Published: March 2022

Hospital arrangement is a place that has a high risk of Healthcare Associated Infection (HAIs). Family behavior and patients undergoing treatment at the hospital greatly influence the emergence of HAIs, one of which is applying handwashing. Health education is one way to improve the accuracy of hand washing 6 steps the first moment. The purpose of this study was to determine the difference in the accuracy of the implementation of hand washing in the patient's family with and without the provision of health education using the hand hygiene demonstration method in Irna 2 Surgery Room, RSUD Dr. Saiful Anwar Malang. Method: The design of this study was a quasi-experimental study with a non-equivalent control group design. The treatment group was given an intervention in the form of demonstration method handwashing education, while the control group was not given an intervention. 26 respondents as the control group and 26 respondents as the treatment group. Result and analysis: The results obtained 14 respondents (53.85%) in the control group did not wash their hands properly. 17 respondents (65.38%) in the intervention group washed their hands properly. There is a difference in the accuracy of hand washing in the patient's family in IRNA 2 Surgical Class 3 of RSUD Dr. Saiful Anwar Malang between control and intervention groups (p<0.05). Health education demonstration method increases the accuracy of handwashing in the patient's family. It is hoped that education about 6 steps of hand washing will continue.
HUBUNGAN ANTARA MOTIVASI PERAWAT DENGAN SIKAP PENDOKUMENTASIAN ASUHAN KEPERAWATAN
Authors: Andreas Andreas Aditya Noviawan 
Published: March 2022

Tujuan Studi: Tujuan penelitian ini untuk mengetahui hubungan antara motivasi perawat dengan sikap pendokumentasian asuhan keperawatan.
Metodologi: Penelitian ini merupakan penelitian Kuantitatif dengan pendekatan Cross Sectional. Dalam penelitian ini populasinya adalah seluruh perawat IRNA 1 yang berjumlah 171 responden dengan teknik sampel Probability Sampling. Sampel diambil secara Simple Random Sampling yang memenuhi kriteri inklusi eksklusi didapatkan 120 responden. Pengumpulan data dilakukan selama 8 hari menggunakan kuesioner.
Hasil: Dari hasil penelitian didapatkan sebagian besar responden menunjukan motivasi sedang sebanyak 105 responden (87.50%), sedangkan sikap pendokumentasian asuhan keperawatan sebagian besar responden menunjukan sikap yang negative sebanyak 63 responden (52.5%). Hasil uji korelasi Rank Spearman menunjukkan hubungan yang signifikan dengan nilai p< 0.05 (p= 0.000< 0.05) antara motivasi perawat dengan sikap pendokumentasian asuhan keperawatan di IRNA 1 RSUD DR Saiful Anwar Malang, dengan tingkat korelasi lemah r= 0.391 serta korelasi bernilai positif maka hubungan bersifat searah, artinya semakin tinggi motivasi perawat maka semakin positif sikap pendokumentasian asuhan keperawatan.
Manfaat: Penelitian ini dapat digunakan untuk meningkatkan kualitas motivasi perawat dengan sikap pendokumentasian asuhan keperawatan di IRNA 1 RSUD. DR Saiful Anwar Malang.
Computed Tomography-Based Machine Learning Differentiates Adrenal Pheochromocytoma From Lipid-Poor Adenoma
Authors: Liu Haipeng , Guan Xiao , Xu Beibei , Zeng Feiyue , Chen Changyong , Yin Hong ling , Yi Xiaoping , Peng Yousong , Chen Bihong T. 
Published: March 2022

ObjectivesTo assess the accuracy of computed tomography (CT)-based machine learning models for differentiating subclinical pheochromocytoma (sPHEO) from lipid-poor adenoma (LPA) in patients with adrenal incidentalomas.Patients and MethodsThe study included 188 tumors in the 183 patients with LPA and 92 tumors in 86 patients with sPHEO. Pre-enhanced CT imaging features of the tumors were evaluated. Machine learning prediction models and scoring systems for differentiating sPHEO from LPA were built using logistic regression (LR), support vector machine (SVM) and random forest (RF) approaches.ResultsThe LR model performed better than other models. The LR model (M1) including three CT features: CTpre value, shape, and necrosis/cystic changes had an area under the receiver operating characteristic curve (AUC) of 0.917 and an accuracy of 0.864. The LR model (M2) including three CT features: CTpre value, shape and homogeneity had an AUC of 0.888 and an accuracy of 0.832. The S2 scoring system (sensitivity: 0.859, specificity: 0.824) had comparable diagnostic value to S1 (sensitivity: 0.815; specificity: 0.910).ConclusionsOur results indicated the potential of using a non-invasive imaging method such as CT-based machine learning models and scoring systems for predicting histology of adrenal incidentalomas. This approach may assist the diagnosis and personalized care of patients with adrenal tumors.
Effects of Different Cropland Reclamation Periods on Soil Particle Size and Nutrients From the Perspective of Wind Erosion in the Mu Us Sandy Land
Authors: Liu Xiufan , Du Heqiang , Li Sen , Wang Tao , Fan Yawei 
Published: March 2022

Land use changes could notably influence the magnitude and distribution of wind erosion. In recent decades, land reclamation flourished in the Mu Us Sandy Land (MUSL) to supplement cultivated lands (CLs) occupied by urbanization. To analyze the effects of land reclamation on wind erosion, the soil texture and soil nutrients in arable and uncultivated lands should be evaluated. In this study, we collected 54 paired soil samples from CLs and nearby uncultivated lands (NULs) in the MUSL considering land use data pertaining to different phases. Then, the soil particle distribution (PSD) and contents of soil organic carbon (SOC) and total nitrogen (TN) were measured in the laboratory. The results indicated that after 1–15 years (Yr) of cultivation, compared to the NULs, particles ranging from 60 to 400 μm obviously decreased. With increasing number of cultivation years, the wind sorting effects accumulated, and the content of erodible particles susceptible to wind erosion decreased. Among the CLs with different cultivation years, new CLs exhibited the highest erodible particle content, and medium CLs exhibited the lowest erodible particle fraction content. The SOC contents in the medium and fine sand groups among the new CLs was significantly influenced by wind erosion, whereas the TN content was primarily controlled by nitrogenous fertilizer application. After cultivation for longer than 40 years, the total SOC and TN contents in the CLs were significantly higher than those in the NULs. Among the CLs, the wind sorting effects and number of cultivation years obviously influenced the SOC content, whereas the TN content in the CLs was mainly influenced by nitrogenous fertilizer utilization. Rapid urbanization of Shaanxi Province, a new round of national ecological policy adjustments and altered wind environments are the main reasons for the development of new CLs, and a superior location and soil physicochemical properties contribute to the occurrence of old CLs. Based on the above analysis, we propose that conservative cultivation is the key to the protection of new CLs from wind erosion hazards.
CD8+ T-Cell Exhaustion Phenotype in Chronic Hepatitis C Virus Infection Is Associated With Epitope Sequence Variation
Authors: Osuch Sylwia , Laskus Tomasz , Perlejewski Karol , Berak Hanna , Bukowska-Ośko Iwona , Pollak Agnieszka , Zielenkiewicz Magdalena , Radkowski Marek , Caraballo Cortés Kamila 
Published: March 2022

Background and AimsDuring chronic hepatitis C virus (HCV) infection, CD8+ T-cells become functionally exhausted, undergoing progressive phenotypic changes, i.e., overexpression of “inhibitory” molecules such as PD-1 (programmed cell death protein 1) and/or Tim-3 (T-cell immunoglobulin and mucin domain-containing molecule-3). The extreme intrahost genetic diversity of HCV is a major mechanism of immune system evasion, facilitating epitope escape. The aim of the present study was to determine whether T-cell exhaustion phenotype in chronic HCV infection is related to the sequence repertoire of NS3 viral immunodominant epitopes.MethodsThe study population was ninety prospective patients with chronic HCV genotype 1b infection. Populations of peripheral blood CD8+ T-cells expressing PD-1/Tim-3 were assessed by multiparametric flow cytometry, including HCV-specific T-cells after magnetic-based enrichment using MHC-pentamer. Autologous epitope sequences were inferred from next-generation sequencing. The correction of sequencing errors and genetic variants reconstruction was performed using Quasirecomb.ResultsThere was an interplay between the analyzed epitopes sequences and exhaustion phenotype of CD8+ T-cells. A predominance of NS31406 epitope sequence, representing neither prototype KLSGLGLNAV nor cross-reactive variants (KLSSLGLNAV, KLSGLGINAV or KLSALGLNAV), was associated with higher percentage of HCV-specific CD8+PD-1+Tim-3+ T-cells, P=0.0102. Variability (at least two variants) of NS31406 epitope sequence was associated with increased frequencies of global CD8+PD-1+Tim-3+ T-cells (P=0.0197) and lower frequencies of CD8+PD-1−Tim-3− T-cells (P=0.0079). In contrast, infection with NS31073 dominant variant epitope (other than prototype CVNGVCWTV) was associated with lower frequency of global CD8+PD-1+Tim-3+ T-cells (P=0.0054).ConclusionsOur results indicate that PD-1/Tim-3 receptor expression is largely determined by viral epitope sequence and is evident for both HCV-specific and global CD8+ T-cells, pointing to the importance of evaluating autologous viral epitope sequences in the investigation of CD8+ T-cell exhaustion in HCV infection.
SARS-COV-2 Infection, Vaccination, and Immune-Mediated Diseases: Results of a Single-Center Retrospective Study
Authors: Luchetti Gentiloni Michele Maria , Paci Valentino , Marconi Valentina , Gigli Marco , Benfaremo Devis , Sordillo Raffaella , Macchini Cristina , Massaccesi Leonardo , Perna Gian Piero , Offidani Anna Maria , Moroncini Gianluca 
Published: March 2022

ObjectivesThe relationship between infections or vaccine antigens and exacerbations or new onset of immune-mediated diseases (IMDs) has long been known. In this observational study, conducted during the COVID-19 pandemic, we evaluated the onset of clinical and laboratory immune manifestations related to COVID-19 or SARS-CoV-2 vaccination.MethodsFour groups of patients were evaluated: A) 584 COVID-19 inpatients hospitalized from March 2020 to June 2020 and from November 2020 to May 2021; B) 135 outpatients with previous SARS-CoV-2 infection, assessed within 6 months of recovery; C) outpatients with IMDs in remission and flared after SARS-COV-2 infection; D) outpatients with symptoms of probable immune-mediated origin after SARS-CoV-2 vaccination.ResultsIn cohort A we observed n. 28 (4.8%) arthralgia/myalgia, n. 2 (0.3%) arthritis, n. 3 (0.5%) pericarditis, n. 1 (0.2%) myocarditis, n. 11 (1.9%) thrombocytopenia or pancytopenia, and in the follow up cohort B we identified 9 (6.7%) cases of newly diagnosed IMDs after the recovery from COVID-19. In all cases, serological alterations were not observed.In cohort C we observed n.5 flares of pre-existing IMD after SARS-COV2 infection, and in the cohort D n. 13 IMD temporally close with SARS-CoV-2 vaccination in 8 healthy subjects (with clinical classifiable IMD-like presentation) and in 5 patients affected by an anamnestic IMD. Also in these latter cases, except in 2 healthy subjects, there were not found serological alterations specific of a classifiable IMD.ConclusionsThis study suggests that the interplay between SARS-CoV-2 and the host may induce complex immune-mediated reactions, probably induced by the anti-spike antibodies, in healthy people and IMD patients without specific serological autoimmunity. Moreover, our data suggest that the anti-SARS-CoV-2 antibodies generated by the vaccination may cause in healthy subjects’ clinical manifestations similar to well-definite IMDs. These findings support the hypothesis that SARS-Cov2 infection in COVID-19 induce an innate and adaptive immune response that may be both responsible of the symptoms correlated with the occurrence of the IMDs described in our study. And, in this context, the IMDs observed in healthy people in close temporal correlation with the vaccination suggest that the anti-Spike antibodies may play a key role in the induction of an abnormal and deregulated immune response.
Comparative Efficacy and Safety of 11 Drugs as Therapies for Adults With Neuropathic Pain After Spinal Cord Injury: A Bayesian Network Analysis Based on 20 Randomized Controlled Trials
Authors: Ling Hai-Qian , Chen Zi-Hao , He Lei , Feng Feng , Weng Chuang-Gui , Cheng Si-Jin , Rong Li-Min , Xie Pei-Gen 
Published: March 2022

ObjectiveTo provide an updated analysis of the efficacy and safety of drugs for the management of neuropathic pain (NP) after spinal cord injury (SCI) based on Bayesian network analysis.MethodsA Bayesian network meta-analysis of literature searches within PubMed, Cochrane Library, Embase, and Web of Science databases from their inception to February 21 2021 was conducted without language restrictions. Paired and network meta-analyses of random effects were used to estimate the total standardized mean deviations (SMDs) and odds ratios (ORs).ResultsA total of 1,133 citations were identified and 20 RCTs (including 1,198 patients) involving 11 drugs and placebos for post-SCI NP selected. The 5 outcomes from all 11 drugs and placebos had no inconsistencies after Bayesian network analysis. BTX-A gave the most effective pain relief for the 4 weeks, following a primary outcome. No significant differences were found among drugs with regard to adverse events of the primary outcome. Gabapentin, BTX-A, and pregabalin were found to be the most helpful in relieving secondary outcomes of mental or sleep-related symptoms with differences in SMDs, ranging from −0.63 to −0.86. Tramadol triggered more serious adverse events than any of the other drugs with differences in ORs ranging from 0.09 to 0.11.ConclusionBTX-A, gabapentin, pregabalin, amitriptyline, ketamine, lamotrigine, and duloxetine were all effective for NP management following SCI. Lamotrigine and gabapentin caused fewer side effects and had better efficacy in relieving mental or sleep-related symptoms caused by SCI-related NP. Tramadol, levetiracetam, carbamazepine, and cannabinoids could not be recommended due to inferior safety or efficacy.Systematic Review Registration[https://inplasy.com/inplasy-2020-7-0061/], identifier [INPLASY202070061].