bluuebunny/crossref_metadata_2025_split huggingface dataset:
Study of the Protective Properties of 2-Ethyl-6-Methyl-3-Hydroxypyridine
Malate in the Model of In vitro-Induced Oxidative Stress in Myoblast Cell
Culture
Authors: Furalyov Vladimir A. , Kukes Vladimir G. , Gazdanova Albina А. , Parfenova Olga K. , Sidorov Nikita G. , Kurkin Roman V. 
Published: November 2022

Background:
A cellular model of oxidative stress induced by hydrogen peroxide in the
primary culture of myoblasts was obtained by in vitro experiments, and the possibility of exogenous
regulation of the cytotoxic effect using 2-ethyl-6-methyl-3-hydroxypyridine malate (ethoxidol)
was studied. Moreover, the influence of oxidative stress and the effect of ethoxidol on the
intracellular expression of such an important biomarker as myostatin was investigated.

Methods:
Hydrogen peroxide was used to induce oxidative stress. The effect of hydrogen peroxide
on the rate of myoblast proliferation was studied by measuring the reduction level of (3-(4,5-
dimethylthiazole-2-yl))-2,5-diphenyltetrazolium bromide. To measure the expression of myostatin,
a real-time polymerase chain reaction (PCR-RV) method was used.

Results:
During the work, it was clearly demonstrated that hydrogen peroxide has a significant
cytostatic effect on myoblasts in vitro, inhibiting their proliferation. Ethoxidol in physiological
concentration did not show toxic effects and did not inhibit cell proliferation. This antioxidant revealed
a statistically significant protective effect on the cytostatic effect of hydrogen peroxide on
myoblasts. In addition, this compound inhibited the expression of myostatin mRNA caused by
exposure to hydrogen peroxide as a negative regulator of growth and differentiation of muscle
tissue that occurs in response to exposure to reactive oxygen species.

Conclusion:
Hydrogen peroxide is one of the highly active forms of oxygen and has a significant
cytostatic effect on myoblasts in vitro, suppressing their proliferation. 2-ethyl-6-methyl-3-
hydroxypyridine malate neutralizes the toxic effect of peroxide, thereby indirectly having a positive
effect on the rate of myoblast proliferation in vitro.
Modifiable and Non-modifiable Risk Factors Affecting Oral and Periodontal Health and Quality of Life in South Asia
Authors: Karobari Mohmed Isaqali , Siddharthan S , Adil Abdul Habeeb , Khan Mohammed Mansoor , Venugopal Adith , Rokaya Dinesh , Heboyan Artak , Marya Charu Mohan , Marya Anand 
Published: November 2022

Objectives:
The study aimed to review the prevalence of periodontal disease and associated factors among developing South Asian countries. The review was also aimed at providing an insight into how such factors play a role in affecting the Quality of life of patients with compromised oral health.

Background:
It has been observed that Oral health directly correlates with the Quality of life of an individual, so it is imperative to understand this, particularly in the developing parts of the world.

Methods:
A MeSH keyword search was carried out with the keywords: Periodontal diseases, Oral Health, Public Health, Asia, QoL, Quality of Life, Southeast Asia, Tobacco, and Risk Factors, and based on the findings, this detailed review was compiled.

Results:
The South Asian population forms 24.89% of the world population, while periodontal disease is an inflammatory condition that affects 11% of the globe. Several studies previously conducted across developing countries have shown that various factors like the socioeconomic status of an individual, smoking habit, consumption of alcohol, hypertension, history of diabetes, obesity, and stress are indirectly related to the onset of periodontal disease. Characteristics associated with specific populations like ethnicity, behavioral characteristics, and environmental factors may affect causing periodontitis.

Conclusion:
Dental practitioners in this region should consider risk factors that can be altered significantly to uplift the periodontal health status of an individual, which is not being considered in many developing countries.
Narrative Review of Anti-CD3 Antibody and Anti-CD20 Antibody:
Immunotherapeutic Strategies to Treat and Prevent Type 1 Diabetes
Authors: Desai Shivani , Kashalikar Prajakta , Sanap Avinash , Shekatkar Madhura , Bhonde Ramesh 
Published: November 2022

Background and Objective:
Type 1 diabetes mellitus is a complex disease defined by
the loss of pancreatic cells, which leads to complete insulin insufficiency. The Diabetes Control
and Problems Trial defines the aims of Type 1 diabetes therapy as achieving adequate glycaemic
control, and preventing and avoiding recurrent bouts of hypoglycaemia. Despite ongoing efforts to
improve insulin therapy regimens, the actual hormone substitute therapy treats just the symptoms
of the disease, with no influence on disease pathology or etiopathogenesis. In recent decades, there
has been a lot of interest in preventative techniques in high-risk patients, based on the theory that
if a therapeutic intervention is adopted early in the disease, it can help maintain endogenous cell
function by protecting the remaining cell reservoir from autoimmune attack.

Methods:
Based on preclinical and clinical data, we have discussed some immunotherapeutic in
this meta-analysis. We referred to the preclinical and clinical studies for teplizumab and rituximab
from authentic databases and compiled the data. We used statistical analysis to do a meta-analysis.

Results:
In two immunotherapeutic anti-CD3 antibodies and anti-CD20 antibodies examples, teplizumab
and rituximab, respectively, shows better efficacy as well as fewer side effects. We have
discussed this drug briefly based on their mechanism of action and meta-analysis, which compare
clinical efficacy.

Conclusion:
Immunotherapeutic can be a better option for preventing and protecting type one diabetes.
Since, the existing literature does not have enough data to support any single drug concluding
the same will not be appropriate. Hence further studies are required wherein different drugs
can be compared with similar sample sizes for each group of drugs.
The Relationship Between Social Integration and Physical Activity, Diet, and Sleep Among Youths: Cross-sectional Survey Study
Authors: Wray Bridget , Grimes Amanda , Eighmy Katlyn , Lightner Joseph 
Published: November 2022

Background
Social integration has been shown to predict physical activity (PA), diet, and sleep in adults. However, these associations have not been well-studied in youth samples. Using a life course perspective, it is imperative to study this in youths as social and health behaviors are established early in life.

Objective
The purpose of this study was to understand the relationship between social integration and PA, diet, and sleep for urban, middle-school youth.

Methods
Cross-sectional baseline data from middle-school youths (N=73) who participated in an afterschool health behavior intervention were included in this study.

Results
Time with friends significantly predicted moderate to vigorous intensity PA (β=.33, P=.02). Time spent with family was significantly related to fruit consumption (t66=1.38, P=.005) and vegetable consumption (t72=1.96, P=.01).

Conclusions
Social integration appears to be related to both PA and nutrition behaviors in youths. Future research should expand on our findings to explain how different domains of social integration may impact youths’ health behaviors.

International Registered Report Identifier (IRRID)
RR2-10.2196/37126
A Serious Game for Patients With Eating Disorders (Maze Out): Pilot User Experience and Acceptance Study
Authors: Guala Maria Mercedes , Bul Kim , Skårderud Finn , Søgaard Nielsen Anette 
Published: November 2022

Background
Eating disorders (EDs) are severe mental disorders associated with notable impairments in the quality of life. Despite the severity of the disorders and extensive research in the field, effective treatment for EDs is lacking. Digital interventions are gaining an evidence-based position in mental health, providing new perspectives in psychiatric treatment. Maze Out is a serious game coproduced by patients and therapists that focuses on supporting patients with EDs.

Objective
The aim of this study was to investigate the experiences of engaging in and acceptability of Maze Out among patients with EDs and therapists.

Methods
This study is a qualitative pilot study involving data collected through focus groups and individual interviews and user analytics collected through the game. The participants were recruited from the Odense Mental Health Service of the Region of Southern Denmark. Qualitative interviews analyzed by thematical analysis and interpreted by interpretative phenomenological analysis were used to evaluate the acceptance and experience of Maze Out among patients and therapists. The mobile health evidence reporting and assessment checklist was used to describe the content, context, and technical features of the game in a standardized manner for mobile health apps.

Results
The participants found Maze Out to be engaging, easy to use, and a good platform for reflecting on their disorder. They primarily used Maze Out as a conversational tool with their close relationships, giving them insights into the experiences and daily life struggles of someone with EDs.

Conclusions
Maze Out seems to be a promising tool supplementing the current ED treatment. Further research should focus on evaluating the effectiveness of the game and its potential to support patients with different types of EDs.
Sentiment Analysis of Insomnia-Related Tweets via a Combination of Transformers Using Dempster-Shafer Theory: Pre– and Peri–COVID-19 Pandemic Retrospective Study
Authors: Maghsoudi Arash , Nowakowski Sara , Agrawal Ritwick , Sharafkhaneh Amir , Kunik Mark E , Naik Aanand D , Xu Hua , Razjouyan Javad 
Published: November 2022

Background
The COVID-19 pandemic has imposed additional stress on population health that may result in a change of sleeping behavior.

Objective
In this study, we hypothesized that using natural language processing to explore social media would help with assessing the mental health conditions of people experiencing insomnia after the outbreak of COVID-19.

Methods
We designed a retrospective study that used public social media content from Twitter. We categorized insomnia-related tweets based on time, using the following two intervals: the prepandemic (January 1, 2019, to January 1, 2020) and peripandemic (January 1, 2020, to January 1, 2021) intervals. We performed a sentiment analysis by using pretrained transformers in conjunction with Dempster-Shafer theory (DST) to classify the polarity of emotions as positive, negative, and neutral. We validated the proposed pipeline on 300 annotated tweets. Additionally, we performed a temporal analysis to examine the effect of time on Twitter users’ insomnia experiences, using logistic regression.

Results
We extracted 305,321 tweets containing the word insomnia (prepandemic tweets: n=139,561; peripandemic tweets: n=165,760). The best combination of pretrained transformers (combined via DST) yielded 84% accuracy. By using this pipeline, we found that the odds of posting negative tweets (odds ratio [OR] 1.39, 95% CI 1.37-1.41; P<.001) were higher in the peripandemic interval compared to those in the prepandemic interval. The likelihood of posting negative tweets after midnight was 21% higher than that before midnight (OR 1.21, 95% CI 1.19-1.23; P<.001). In the prepandemic interval, while the odds of posting negative tweets were 2% higher after midnight compared to those before midnight (OR 1.02, 95% CI 1.00-1.07; P=.008), they were 43% higher (OR 1.43, 95% CI 1.40-1.46; P<.001) in the peripandemic interval.

Conclusions
The proposed novel sentiment analysis pipeline, which combines pretrained transformers via DST, is capable of classifying the emotions and sentiments of insomnia-related tweets. Twitter users shared more negative tweets about insomnia in the peripandemic interval than in the prepandemic interval. Future studies using a natural language processing framework could assess tweets about other types of psychological distress, habit changes, weight gain resulting from inactivity, and the effect of viral infection on sleep.
Menstrual Abnormalities and Reproductive Lifespan in Females with CKD
Authors: Rytz Chantal L. , Kochaksaraei Golasa Samedi , Skeith Leslie , Ronksley Paul E. , Dumanski Sandra M. , Robert Magali , Ahmed Sofia B. 
Published: November 2022

Background and objectives
Menstrual abnormalities and shortened reproductive lifespan are associated with shorter life expectancy and higher cardiovascular and osteoporosis risk in the general population, although the magnitude of these reproductive factor irregularities in females with CKD is unclear. This systematic review and meta-analysis aimed to summarize the current knowledge regarding menstrual abnormalities and reproductive lifespan among females with CKD.

Design, setting, participants, & measurements
A comprehensive bibliographic search (MEDLINE, Embase, and Cumulative Index to Nursing and Allied Health Literature [CINAHL]) was completed from database inception to February 2022 to identify all original articles reporting on females of reproductive age with nondialysis-dependent/nonkidney transplant CKD, dialysis-dependent CKD, or kidney transplantation and menstruation patterns, age of menarche, and/or menopause. Data extraction and study quality assessment were completed in duplicate. Random effects meta-analyses were used to derive pooled proportions estimates.

Results
Forty-six studies were identified, and 35 were meta-analyzed, stratified by KRT modality and reported outcome. Menstrual abnormalities were present in 19%–47% of patients on hemodialysis and 75% of patients on peritoneal dialysis. Kidney transplantation was associated with a 7%–30% decrease in menstrual abnormalities. Reproductive lifespan was 32 years (95% confidence interval, 30 to 34 years). Although significant heterogeneity was present, study quality ranged from fair to good, and no evidence of publication bias was noted.

Conclusions
Menstrual abnormalities and shorter reproductive lifespan are common in females with CKD, although kidney transplantation may improve menstrual health.
The Influence of Service Quality and Store Atmosphere on Customer Satisfaction at Vocational High School Business Center in Cirebon
Authors: Nurhajijah Sitta , Dewi Isti Riana , Aisy Rohadatul 
Published: November 2022

The purpose of this research was to find out the influence between service quality and the atmosphere of the store on customer satisfaction at the Business Center at a vocational high school in Lemahabang Cirebon. Research methods used are validity test, reliability test, and multiple Linear Regression. The analysis tool used is the SPSS tool. The results of this study explain the influence between service quality of the store and the atmosphere of the store on customer satisfaction. This indicates that there needs to be an improvement of services such as honest words and friendly behavior to improve the quality of store service and modify the temperature and layout of goods to be more varied to entice customers to feel happy and make more visits to support the success of the business.
Keywords: service quality, store atmosphere, customer satisfaction
Analysis of Effect on the Working Environment, Work Motivation, and Discipline on Performance Employees of PT. Seimitsu Indonesia
Authors: Daspar  , Restiani Liska 
Published: November 2022

ABSTRACT
This study aims to examine the influence of the work environment, work motivation, and work discipline on the performance of employees of PT Fuji Seimitsu Indonesia. The sampling method used was technique sampling non probability saturated sampling technique so that the entire population that is, 70 people were sampled. This type of research is quantitative, for data This research was obtained from a questionnaire that has been filled in by the employees of PT Fuji Seimitsu Indonesia. The analytical method used is the validity test, reliability test, classical assumption test, multiple linear analysis test, and coefficient determination in the IBM SPSS 22 for Windows program. The results of the work environment hypothesis test show t arithmetic> t table (2.016> 1.997) then there is an influence between the work environment on performance employees, the results of the work motivation hypothesis test show t arithmetic <t table (-0.823 <1.997) then there is no influence between work motivation on employee performance, while the results of the work discipline hypothesis test showed t count> t table (5.107> 1.997) then there is an influence between work discipline on employee performance, and simultaneously shows Fcount> F table (22,582> 2,744) then there is an influence between work environment, work motivation, and work discipline on employee performance.
Sejarah Masjid Al-Iman di Desa Telaga, Kecamatan Kamipang, Kabupaten Katingan, Provinsi Kalimantan Tengah, 1939-2020
Authors: Hermanto Hermanto , Suryanti2 Suryanti 
Published: November 2022

Eksistensi masjid bagi umat Islam dipahami sebagai tempat suci dan sakral, sekaligus ruang untuk menuju alam lain dan berinteraksi dengan Tuhan. Tujuan yang hendak dicapai dalam penelitian ini adalah untuk mengetahui sejarah Islam dan dakwah Islam yang dilakukan dalam kegiatan di masjid untuk nilai-nilai sosial, pendidikan Islam dan bagaimana revitasisasi fungsi masjid untuk penguatan nilai-nilai sosial masyarakat, pendidikan Islam di Masjid Al-Iman Desa Telaga Kecamatan Kamipang Kabupaten Katingan. Penelitian ini adalah penelitian lapangan (field research) yang bersifat deskriptif kualitatif. Adapun informan dalam penelitian ada 11 informan dengan kriteria informan yang diambil disesuaikan dengan kepentingan penelitian. Secara umum, informan yang diambil adalah berstatus mengetahui sejarahnya yang berusia antara 33-108 tahun. Dalam tehnik pengumpulan data metode yang digunakan adalah metode observasi, wawancara, dan dokumentasi. Untuk dapat mempermudah peneliti dalam melakukan penulisan tentunya, maka dibuatlah rumusan masalah (1) Bagaimana Sejarah dan Proses Islamisasi di Desa Telaga Kecamatan Kamipang? (2) Apa saja Peranan Masjid Al-Iman dalam Islamisasi di Desa Telaga Kecamatan Kamipang? Hasil penelitian yang telah didapati bahwa, masuknya Islam di desa Telaga dibawa oleh Saun pada tahun 1920 yang sudah beragama Islam, walaupun pada saat itu tradisi suku Dayak masih dilakukan sebagai salah satu Syariat. Islamisasi yang terjadi di desa Telaga dilakukan melalui beberapa jalur Islamisasi diantaranya ialah: perdagangan, perkawinan, tasawuf dan kesenian (seni bela diri/kuntau). Salah satu tokoh penyebar Islam di Desa Telaga adalah Abdul Qadir yang berasal dari Lupak yakni Banjarmasin Kalimantan Selatan yang menikah dengan salah satu masyarakat suku Dayak. Bukti meluasnya Islam ditandai dengan didirikan bangunan Masjid Al-Iman yang sekarang dijadikan sebagai tempat ibadah juga dijadikan sebagai pusat kegiatan masyarakat di Desa Telaga. Berdasarkan hasil penelitian tersebut dapat disimpulkan bahwa Masjid Al-Iman memiliki peran yang besar dalam Islamisasi Di Desa Telaga.
Iklan Madu HNI di Instagram dalam Pasar Komodifikasi Islam
Authors: Annafis Lulu Al , Nawawi Ahmad , Ikhsan Favi Aditya 
Published: November 2022

Komodifikasi agama di Indonesia kini marak terjadi. Agama kerap dilibatkan dalam setiap lini kehidupan, termasuk dalam bidang ekonomi. Indonesia sebagai negara muslim terbesar di dunia memiliki potensi pasar muslim yang menjanjikan. Dalam proses pemasaran produk, tidak jarang para produsen menggunakan isu agama guna menarik perhatian konsumen. Oleh karena itu, penelitian ini penting dilakukan untuk melihat bagaimana relasi antara agama dan marketing di Indonesia. Penelitian ini akan mengkaji tentang komodifikasi agama yang dilakukan oleh perusahaan Halal Network International (HNI). HNI adalah sebuah perusahaan yang memiliki standardisasi halal yang bergerak di bidang produk herbal. Salah satu produk HNI adalah madu. Iklan madu HNI inilah yang menjadi kajian penelitian. Artikel ini akan mendeskripsikan bagaimana hubungan antara agama dan marketing pada konteks iklan madu HNI di akun Instagram @pthpai. Pendekatan yang dilakukan adalah pendekatan kualitatif dengan menggunakan metode analisis semiotika Roland Barthes yang akan menjelaskan tentang makna dan tanda-tanda komodifikasi agama pada iklan tersebut. Adapun teori yang digunakan adalah teori komodifikasi agama dan teori Consumer Ritualized Symbolic Practice (CRSP). Tulisan ini menyimpulkan, bahwa komodifikasi agama pada marketing produk HNI ini adalah: 1) Pada iklan madu HNI di Instagram terdapat dua simbol agama yang dikomodifikasi, yaitu potongan ayat Al-Qur'an berupa terjemahan surah An-Nahl:69 dan kata 'halal' pada logo nama perusahaan. 2) Melalui pemaknaan tanda denotasi, konotasi, dan mitos, ayat Al-Qur’an dan kata 'halal' dimaknai sebagai ikon keagamaan yang pada konsep ini diselubungkan ke dalam pasar.
Analisis Sensitivitas Model Black-Litterman Menggunakan Treynor Ratio pada Portofolio Saham
Authors: Ermiati Puja 
Published: November 2022

Investment is an activity that can not separate from return and risk, so that forming portfolio is important to risk minimizing and profit optimizing. One of way to optimizing portfolio is using Black-Litterman model. This model is model that combine equilibrium return by CAPM eith investor’s views about return an asset. Purpose of this research are to form Black-Litterman model with tau calibration and measure the best portfolio performance with treynor ratio. This research used secondary data stock in LQ-45 index during August 2019-January 2020. Selecting portfolio by selecting high return expected CAPM are CPIN, WIKA, ADRO and CTRI. Forming portfolio using Black-Litterman model by calibration so obtain the best measure performance by Treynor Ratio are 0,12142 with =1 and potfolio return 0,26445
Model Matematika Dinamika Penyakit Pneumonia dengan Carriers
Authors: Jelita Windi 
Published: November 2022

Penyakit Pneumonia merupakan penyakit radang paru-paru (alveoli) yang disebabkan oleh bakteri Streptococcus Pneumonia. Dikala sistem imunitas tubuh menurun Streptococcus Pneumonia akan memperbanyak diri serta menimbulkan kerusakan. Individu yang terkolonisasi dengan sptreptococcus pneumonia berperan sebagai reservoir bagi penularan penyakit. Di Indonesia penyakit ini merupakan penyakit endemik. Dalam penelitian ini disajikan model matematika yang mendeskripsikan populasi penyakit pneumonia pada bayi dan balita. Tujuan penelitian ini adalah untuk mengetahui bentuk model matematika pada penyebaran penyakit, mengetahui hasil analisis dan interpretasi dari hasil analisis model matematika penyebaran penyakit pneumonia dengan carriers. Penelitian ini dimulai dengan menentukan variabel, parameter dan asumsi yang berhubungan dengan permasalahan. Model yang telah dibentuk, selanjutnya akan dianalisis. Dari analisis didapat dua titik tetap yaitu bebas penyakit dan endemik. Dari hasil analisis juga didapat kan laju kontak indivu terinfeksi bisa meningkatkan penyebaran sedangkan individu pembawa dan terinfeksi yang memperoleh kekebalan tubuh sementara bisa menekan penyebaran pneumonia.