bluuebunny/crossref_metadata_2025_split huggingface dataset:
The role of risk, regret, and rejoice in non‐instrumental information seeking
Authors: Mechera‐Ostrovsky Tehilla , Liew Shi Xian , Newell Ben R. 
Published: July 2022

AbstractStandard theories suggest that humans should seek information only when it can help them make better decisions. However, recent work suggests that people choose to seek information even when it cannot influence the outcome of a choice. Across three experiments, we examined how this preference for non‐instrumental information was related to the risk, regret, and rejoice associated with different choices. Experiment 1 examined how risk preference informed the appetite for non‐instrumental information and tested how risk and information preference in a gamble‐task related to the desire for knowledge across a range of hypothetical real‐world scenarios. In Experiment 2, we tested how risk, operationalized as variance, related to non‐instrumental information seeking when allowing participants to mentally simulate the potential outcomes of gambles. In Experiment 3, we provided explicit feedback about forgone options, intending to make the potential for regret or rejoice more salient. Taken together, our results show a consistent appetite for information that was robust to changes across all experimental manipulations. We found some evidence of a positive correlation between the desire for knowledge and the level of anticipated regret (Experiment 1), but overall, our data appear more consistent with the idea that non‐instrumental information seeking is driven by a general aversion to uncertainty than by an attempt to regulate specific future emotions.
Snail acetylation by autophagy‐derived acetyl‐coenzyme A promotes invasion and metastasis of KRAS‐LKB1 co‐mutated lung cancer cells
Authors: Han Jang Hee , Kim Yong Keon , Kim Hakhyun , Lee Jooyoung , Oh Myung Joon , Kim Sang Bum , Kim Minjee , Kim Kook Hwan , Yoon Hyun Ju , Lee Myung‐Shik , Minna John D. , White Michael A. , Kim Hyun Seok 
Published: July 2022

AbstractBackgroundAutophagy is elevated in metastatic tumors and is often associated with active epithelial‐to‐mesenchymal transition (EMT). However, the extent to which EMT is dependent on autophagy is largely unknown. This study aimed to identify the mechanisms by which autophagy facilitates EMT.MethodsWe employed a liquid chromatography‐based metabolomic approach with kirsten rat sarcoma viral oncogene (KRAS) and liver kinase B1 (LKB1) gene co‐mutated (KL) cells that represent an autophagy/EMT‐coactivated invasive lung cancer subtype for the identification of metabolites linked to autophagy‐driven EMT activation. Molecular mechanisms of autophagy‐driven EMT activation were further investigated by quantitative real‐time polymerase chain reaction (qRT‐PCR), Western blotting analysis, immunoprecipitation, immunofluorescence staining, and metabolite assays. The effects of chemical and genetic perturbations on autophagic flux were assessed by two orthogonal approaches: microtubule‐associated protein 1A/1B‐light chain 3 (LC3) turnover analysis by Western blotting and monomeric red fluorescent protein‐green fluorescent protein (mRFP‐GFP)‐LC3 tandem fluorescent protein quenching assay. Transcription factor EB (TFEB) activity was measured by coordinated lysosomal expression and regulation (CLEAR) motif‐driven luciferase reporter assay. Experimental metastasis (tail vein injection) mouse models were used to evaluate the impact of calcium/calmodulin‐dependent protein kinase kinase 2 (CAMKK2) or ATP citrate lyase (ACLY) inhibitors on lung metastasis using IVIS luciferase imaging system.ResultsWe found that autophagy in KL cancer cells increased acetyl‐coenzyme A (acetyl‐CoA), which facilitated the acetylation and stabilization of the EMT‐inducing transcription factor Snail. The autophagy/acetyl‐CoA/acetyl‐Snail axis was further validated in tumor tissues and in autophagy‐activated pancreatic cancer cells. TFEB acetylation in KL cancer cells sustained pro‐metastatic autophagy in a mammalian target of rapamycin complex 1 (mTORC1)‐independent manner. Pharmacological inhibition of this axis via CAMKK2 inhibitors or ACLY inhibitors consistently reduced the metastatic capacity of KL cancer cells in vivo.ConclusionsThis study demonstrates that autophagy‐derived acetyl‐CoA promotes Snail acetylation and thereby facilitates invasion and metastasis of KRAS‐LKB1 co‐mutated lung cancer cells and that inhibition of the autophagy/acetyl‐CoA/acetyl‐Snail axis using CAMKK2 or ACLY inhibitors could be a potential therapeutic strategy to suppress metastasis of KL lung cancer.
Anaemia and pathologic complete response rate according to carboplatin dose in HER2+ breast cancer treated with neoadjuvant TCHP
Authors: Ji Jung Hwan , Bae Soong June , Kim Seul‐Gi , Kim Min Hwan , Kim Gun‐Min , Sohn Joohyuk , Jeong Joon , Kim Jee Hung , Ahn Sung Gwe 
Published: July 2022

AbstractGrade 3/4 anaemia, which is mainly induced by carboplatin, frequently occurs in patients treated with neoadjuvant docetaxel/carboplatin/trastuzumab/pertuzumab (TCHP). However, dose reduction of carboplatin may raise concerns about the oncological outcome. This study investigated the pathologic complete response (pCR) rate, occurrence of grade 3/4 anaemia, and transfusion rate according to carboplatin dose in patients treated with neoadjuvant TCHP. We retrospectively analysed 294 patients treated with neoadjuvant TCHP between April 2015 and December 2020. Case matching was performed using propensity score matching. Among patients treated with neoadjuvant TCHP, carboplatin area under the plasma concentration–time curve 6 (AUC6) was used in 234 patients (79.6%) and upfront carboplatin AUC5 was used in 60 patients (20.4%). No significant difference in pCR rate was found between the two groups (AUC6: 70.9%, AUC5: 80.0%). In both oestrogen receptor‐positive (ER+) and ER‐ patients, no significant differences were observed between the AUC6 and AUC5 groups (ER+: 54.3% vs. 50.0%, ER‐: 81.7% vs. 86.0%). The case‐matched cohort showed consistent findings. The AUC5 group had lower frequencies of grade 3/4 anaemia (18.3% vs. 34.2%) and transfusion events (10.0% vs. 21.8%) than the AUC6 group. Compared with AUC5, carboplatin at AUC6 would associate with a 2.7‐fold increased risk of grade 3 or 4 chemotherapy‐induced anaemia. Carboplatin AUC5 has comparable cytotoxic effects to carboplatin AUC6 in patients with HER2+ breast cancer treated with six cycles of neoadjuvant TCHP, with fewer complications associated with clinically meaningful anaemia. AUC5 may be the optimal carboplatin dose to reduce TCHP‐induced anaemia in patients with HER2+ breast cancer treated with TCHP.
Anticancer Water‐Soluble Organoruthenium Complexes: Synthesis and Preclinical Evaluation
Authors: Azmanova Maria , Rafols Laia , Cooper Patricia A. , Seaton Colin C. , Shnyder Steven D. , Pitto‐Barry Anaïs 
Published: July 2022

AbstractThe synthesis, characterisation, and evaluation of the in vitro cytotoxicity of five maleonitriledithiolate‐based ruthenium metal complexes bearing various phosphine ligands towards two ovarian cancer cell lines (A2780 and A2780cisR), one non‐small‐cell lung cancer cell line (H460) and one normal prostate cell line (PNT2) are presented herein. These 18‐electron complexes were designed with four water‐soluble phosphine ligands to increase the water‐solubility character of the corresponding electron‐deficient ruthenium complex which showed great in vitro promises, and triphenylphosphine for comparison. The complexes with triphenylphosphine‐3,3′,3′′‐trisulfonic acid and triphenylphosphine present similar cytotoxicity compared to the 16‐electron precursor, with equal cytotoxicity to both A2780 and A2780cisR. Hints at the mechanism of action suggest an apoptotic pathway based on reactive oxygen species (ROS) production. No toxicity was observed in preliminary in vivo pilot studies for these two complexes in subcutaneous A2780 and A2780cisR xenograft models, with some evidence of tumour growth delay.
Bioconjugation Strategies for Tobacco Mild Green Mosaic Virus
Authors: González‐Gamboa Ivonne , Caparco Adam A. , McCaskill Justin M. , Steinmetz Nicole F. 
Published: July 2022

AbstractTobacco mild green mosaic virus (TMGMV) is a plant virus closely related to Tobacco mosaic virus (TMV), sharing many of its structural and chemical features. These rod‐shaped viruses, comprised of 2130 identical coat protein subunits, have been utilized as nanotechnological platforms for a myriad of applications, ranging from drug delivery to precision agriculture. This versatility for functionalization is due to their chemically active external and internal surfaces. While both viruses are similar, they do exhibit some key differences in their surface chemistry, suggesting the reactive residue distribution on TMGMV should not overlap with TMV. In this work, we focused on the establishment and refinement of chemical bioconjugation strategies to load molecules into or onto TMGMV for targeted delivery. A combination of NHS, EDC, and diazo coupling reactions in combination with click chemistry were used to modify the N‐terminus, glutamic/aspartic acid residues, and tyrosines in TMGMV. We report loading with over 600 moieties per TMGMV via diazo‐coupling, which is a >3‐fold increase compared to previous studies. We also report that cargo can be loaded to the solvent‐exposed N‐terminus and carboxylates on the exterior/interior surfaces. Mass spectrometry revealed the most reactive sites to be Y12 and Y72, both tyrosine side chains are located on the exterior surface. For the carboxylates, interior E106 (66.53 %) was the most reactive for EDC‐propargylamine coupled reactions, with the exterior E145 accounting for >15 % reactivity, overturning previous assumptions that only interior glutamic acid residues are accessible. A deeper understanding of the chemical properties of TMGMV further enables its functionalization and use as a multifunctional nanocarrier platform for applications in medicine and precision farming.
Pentachloropseudilin Treatment Impairs Host Cell Invasion by Trypanosoma cruzi
Authors: Spirandelli da Costa Mylla , Borges Bruna Cristina , Marques Isabella Teixeira , de Oliveira Rayane Cristina , Teixeira Thaise Lara , de Gouveia Santos Julia , da Silva Claudio Vieira 
Published: July 2022

AbstractPentachloropseudilin (PClP) is a reversible and allosteric inhibitor of type 1 myosin. Here, we addressed the impact of PClP treatment of Trypanosoma cruzi and mammalian host cell on the parasite migration, cell adhesion and invasion. We observed that PClP was not toxic to either T. cruzi or host cell. Moreover, treatment of T. cruzi with PClP inhabited parasite motility, host cell adhesion and invasion. Treatment of host cell with PClP also impaired parasite invasion probably by decreasing lysosome migration to the entry site of the parasite. Therefore, PClP treatment impaired fundamental processes necessary for a successful T. cruzi infection.
Cleavable Linker Incorporation into a Synthetic Dye‐Nanobody‐Fluorescent Protein Assembly: FRET, FLIM and STED Microscopy
Authors: Aktalay Ayse , Ponsot Flavien , Bossi Mariano L. , Belov Vladimir N. , Hell Stefan W. 
Published: July 2022

AbstractA bright and photostable fluorescent dye with a disulfide (S−S) linker and maleimide group (Rho594‐S2‐mal), as cleavable and reactive sites, was synthesized and conjugated with anti‐GFP nanobodies (NB). The binding of EGFP (FRET donor) with anti‐GFP NB labeled with one or two Rho594‐S2‐mal residues was studied in vitro and in cellulo. The linker was cleaved with dithiothreitol recovering the donor (FP) signal. The bioconjugates (FP‐NB‐dye) were applied in FRET‐FLIM assays, confocal imaging, and superresolution STED microscopy.
The Coordination Chemistry of f‐Block Elements in Molten Salts
Authors: Jiang Shilin , Liu Yalan , Wang Lin , Chai Zhifang , Shi Wei‐Qun 
Published: July 2022

AbstractThe coordination chemistry of f‐block elements (lanthanide and actinide) in molten salts has become a resounding topic in view of its great importance to the research and development (R&D) of molten salt reactors and pyroprocessing. In this Review article, a general overview of the coordination chemistry of f‐block elements in molten salts is provided including past achievements and recent advances. Particular emphases are placed on the oxidation state, speciation, and solution structure of f‐block metal ions in molten salts, as well as their relationships with the salt composition. Furthermore, this review briefly discusses the spectroscopic and theoretical methods that complement each other in revealing the coordination properties.
Thermogravimetric kinetic analysis of the Ce‐Zr composite oxygen carrier prepared by ball milling
Authors: Zhang Weixiang , Liu Yongbin , Zhao Qingpeng , Liu Dawei , Ma Xiaoxun , Xu Long 
Published: July 2022

AbstractA series of zirconium‐doped cerium‐based composite oxygen carriers were prepared using the ball milling method. The results from X‐ray powder diffraction (XRD), H2‐temperature programmed reduction experiments (H2‐TPR), and Brunauer–Emmett–Teller (BET) show that a solid solution, formed from CeO2 and ZrO2, possesses a mesoporous structure and exhibits excellent reaction performance. In addition, carbon nanotubes (CNTs) with an addition amount of 5 wt.% greatly increased the specific surface area of oxygen carriers, thereby improving the activity of solid solutions. In order to further understand the performance of oxygen carriers, the kinetics of H2 reduction of oxygen carriers was studied by thermogravimetric analysis (TGA). The three‐dimensional diffusion model showed the best fitting effect among four typical models (viz., the diffusion‐controlled model, the unreacted shrinking core model, the uniform model, and the nucleation‐nuclei growth model). Finally, the activation energies of CeO2, Ce9Zr1Oδ, and 5 wt.% CNTs Ce9Zr1Oδ were 223.92, 170.96, and 128.60 kJ/mol, respectively, which also correspond with the reactivity sequence of the oxygen carriers.
Layered monitoring of xylenol tail gas treatment process based on stationary subspace analysis
Authors: Xu Feihong , Luan Xiaoli , Liu Fei 
Published: July 2022

AbstractTo deal with the inaccurate monitoring caused by the non‐stationary characteristics of the xylenol tail gas treatment process, a layered monitoring scenario utilizing stationary subspace analysis has been presented in the present study. First, principal component analysis (PCA) is applied to establish the upper‐level stationary monitoring model. Then the sliding time window is used to capture the dynamic information of the remaining non‐stationary features, update the model, and establish the lower non‐stationary monitoring model. Next, the Bayesian information criterion is employed to build the global monitoring model according to the detection results of the upper and lower layers. Finally, the industrial data collected from the industrial boiler is used to evaluate the effectiveness and applicability of the proposed method. It is demonstrated that layered monitoring has higher accuracy than conventional non‐stationary process monitoring techniques. Moreover, it can capture the faults in the stationary features masked by the non‐stationary features.
B‐SCORE – A blockchain based hybrid chaotic signatures for medical image encryption in an IoT environment
Authors: R Naga Priyadarsini , Sathia Bhama Ponsy RK 
Published: July 2022

AbstractInternet of things (IoT) has evolved exponentially in the recent years and its applications are also being explored in the medical field. Due to this, the volume of medical images transmitted has increased multifold. Usage of IoT networks for medical image transmission has significantly reduced the time needed for clinical diagnosis and thereby increasing treatment efficiency. However at present, IoT networks are open to various security threats, which may affect the sensitive and private information that are present in patient's medical image datasets. Existing studies reveal the need of improvisation for secured medical data transmission over IoT networks. In the context to IoT security issues, this research paper proposes blockchain architecture integrated with chaotic encrypted medical image transmission to ensure the high security in medical image transmission. The proposed system incorporates tri‐layered architecture such as Image Aware Segmentation (IAS), hybrid chaotic encryption scheme and finally blockchain environment. The extensive experimentation has been carried out in which the performance parameters such as entropy, NACI and UACI (Number of Pixel Change Ratio and Unified Average Changed Intensity) were calculated and analyzed. It is found that the proposed architecture has NPCR as 99.65%, UACI as 33.95% and entropy ideally close to 8. Encryption results show that the proposed architecture exhibited more randomness, which can defend the IoT security threats.
Flavor quality and composition of accession resources in the North Carolina State University peanut breeding program
Authors: Fritz Katelyn R. , Dean Lisa L. , Hendrix Keith W. , Andres Ryan J. , Newman Cassondra S. , Oakley Andrew T. , Clevenger Josh P. , Dunne Jeffrey C. 
Published: July 2022

AbstractPlant breeders often focus on production traits such as yield and disease resistance, whereas quality traits such as flavor are given low priority. Food manufacturers and consumers have expressed interest in superior flavor experiences suggesting that flavor attributes should play a more prominent role in selection. Flavor attributes were evaluated among a subset of the North Carolina State University (NCSU) peanut germplasm collection to simplify flavor analysis and selection, confirm a recent lack of progress in flavor improvement and identify new sources of flavor improvement in Virginia‐type peanut (Arachis hypogaea L.). Multivariate and principal component analysis identified 11 flavor attributes and five principal components that should facilitate selection of improved peanut flavor. Analysis of historical variety trial data identified a significant deterioration in the roast peanut flavor and a modest improvement in other critical flavor attributes over the last 20 yr. Based on these findings, the accessions ‘Chimera’ and ‘NC Bunch’ were chosen to initiate a crossing program to develop Virginia‐type peanut cultivars with improved roast peanut flavor.
Memristor‐based circuit design of continuously adjustable direct‐current voltage source
Authors: Ding Zhixia , Su Ting , Li Sai , Yang Le 
Published: July 2022

SummaryDirect‐current (DC) voltage source is an essential part in many occasions such as integrated systems and laboratory electricity, which can provide a stable and continuous voltage supply. Traditional voltage sources are frequently designed by bipolar junction and field effect transistors. Compared with these devices, memristors have lower power consumption and smaller size. At present, memristors have been used in the design of logic circuits and other functional circuits, which could provide a new idea for applying memristors into the design of DC voltage sources. In this paper, a memristor‐based circuit design of continuously adjustable DC voltage source is proposed for the first time. The proposed DC voltage source circuit only consists of two modules and has a simple structure. In addition, the output voltage amplitude of this voltage source can be continuously adjusted by the application of a control signal due to the utility of the memristor. The operation process of the whole circuit and the mathematical model between the input and output are analyzed in detail, which is greatly beneficial for use and expansion. Finally, the effectiveness of the circuit is verified in PSPICE, and the accuracy of the output amplitude of the voltage source is also investigated.
Associations of maternal emotion regulation with child white matter connectivity in Black American mother–child dyads
Authors: Wang Chenyang , La Barrie Dominique L. , Powers Abigail , Stenson Anais F. , van Rooij Sanne J. H. , Stevens Jennifer S. , Jovanovic Tanja , Bradley Bekh , McGee Robin E. , Fani Negar 
Published: July 2022

AbstractParental emotion regulation plays a major role in parent‐child interactions, and in turn, neural plasticity in children, particularly during sensitive developmental periods. However, little is known about how parental emotion dysregulation is associated with variation in children's brain structure, which was the goal of this study. Forty‐five Black American mother–child dyads were recruited from an intergenerational trauma study; emotion regulation in mothers and their children (age 8–13 years) was assessed. Diffusion‐weighted images were collected in children; deterministic tractography was used to reconstruct pathways of relevance to emotion regulation. Metrics of white matter connectivity [fractional anisotropy (FA), mean diffusivity (MD)] were extracted for pathways. Socio‐economic variables were also included in statistical models. Maternal emotion dysregulation was the strongest predictor of child fornix MD (r = .35, p = .001), indicating that more severe emotion dysregulation in mothers corresponded with lower fornix connectivity in children. Maternal impulsivity was a strong predictor of child fornix MD (r = .51, p < .001). Maternal emotion dysregulation may adversely influence connectivity of the child.s fornix, a hippocampal‐striatal pathway implicated in reward processes; these associations remained even after accounting for other socio‐environmental factors. Dysregulated maternal emotions may uniquely impact children's adaptation to trauma/stress by affecting networks that support appetitive processing.
Room‐temperature synthesis of flower‐like hierarchical architecture of BiOI and enhanced photocatalytic activity: Application of response surface methodology
Authors: Hai Nguyen Thi Thanh , Long Pham Hai , Tu Vu Van , Thang Phan Quang , Nghia Nguyen Manh 
Published: July 2022

AbstractFlower‐like bismuth oxyiodide (BiOI) hierarchical microspheres were synthesized successfully at room temperature in the presence of ethylene glycol and KI as solvent and iodide source, respectively and applied for the photocatalytic degradation of levofloxacin from aqueous media under visible light irradiation. Optimal conditions for the synthesis and photocatalytic processes were obtained by using the response surface methodology (RSM) combined with central composite design (CCD). Based on the CCD, the quadratic model represents the relationship between the following factors: reactant concentration (0.009–0.116 mol/L), percentage of ethylene glycol (15%–85%) for synthesis processes and contact time (12–108 min), BiOI dosage (0.05–2.45 g/L), and initial concentration (1.1–5.9 mg/L) for photocatalytic processes. The obtained BiOI structures were characterized by scanning electron microscopy (SEM), nitrogen adsorption (BET), X‐ray diffraction (XRD), and UV–Vis absorption spectroscopy. The results show that the proposed quadratic model in accordance with the experiment results in an R2 value and lack of fit F‐values of 0.9987 and 2.79 for synthesis processes, and 0.9977 and 3.06 for photocatalytic processes. It was observed that ethylene glycol not only acted as a solvent but was also a soft temple for the fabrication of flower‐like BiOI hierarchical microspheres. The optimum conditions of reactant concentration and percentage of ethylene glycol for synthesis processes were obtained at 0.063 mol/L and 85%, respectively. Additionally, under visible light irradiation, the synthesized flower‐like BiOI hierarchical microspheres can remove levofloxacin up to 99%. The optimum conditions of contact time, BiOI dosage, and levofloxacin initial concentration for photocatalytic processes were obtained at 90 min, 2 g/L, and 2 mg/L, respectively.