bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of Non‐Muscle Cells on Excitation‐Contraction Coupling in the Heart and the Importance of In Vitro Models
Authors: Belanger Kirstie , Koppes Abigail N. , Koppes Ryan A. 
Published: October 2022

AbstractExcitation‐coupling (ECC) is paramount for coordinated contraction to maintain sufficient cardiac output. The study of ECC regulation has primarily been limited to cardiomyocytes (CMs), which conduct voltage waves via calcium fluxes from one cell to another, eliciting contraction of the atria followed by the ventricles. CMs rapidly transmit ionic flux via gap junction proteins, predominantly connexin 43. While the expression of connexin isoforms has been identified in each of the individual cell populations comprising the heart, the formation of gap junctions with nonmuscle cells (i.e., macrophages and Schwann cells) has gained new attention. Evaluating nonmuscle contributions to ECC in vivo or in situ remains difficult and necessitates the development of simple, yet biomimetic in vitro models to better understand and prevent physiological dysfunction. Standard 2D cell culture often consists of homogenous cell populations and lacks the dynamic mechanical environment of native tissue, confounding the phenotypic and proteomic makeup of these highly mechanosensitive cell populations in prolonged culture conditions. This review will highlight the recent developments and the importance of new microphysiological systems to better understand the complex regulation of ECC in cardiac tissue.
Grid‐responsive smart manufacturing: A perspective for an interconnected energy future in the industrial sector
Authors: Billings Blake W. , Powell Kody M. 
Published: October 2022

AbstractWith the growing amount of renewable energy sources, the grid has become responsible for accounting for intermittency and the flexibility needed to utilize dynamic sources. Expensive peaking plants and energy storage systems have been proposed as ways to mitigate those problems. There is a large group of energy consumers that can respond to grid conditions. Historically, these consumers have been residential and commercial users, but with modern innovations and practices, industrial consumers have the potential to become a major player in this space. Grid‐responsive smart manufacturing can be used to utilize modern tools in manufacturing innovation as enablers for grid response. These modern tools already exist but are not widely used for industrial grid‐side energy management. This article defines grid‐responsive smart manufacturing, identifies five major barriers to its widespread implementation, and portrays the path to getting industrial users to be key players in grid stability and flexibility.
Integrative genomic and transcriptomic profiling reveals distinct molecular subsets in adult mixed phenotype acute leukemia
Authors: Wang Qian , Cai Wen‐zhi , Wang Qin‐rong , Zhu Ming‐qing , Yan Ling‐zhi , Yu Yan , Bao Xie‐bing , Shen Hong‐jie , Yao Hong , Xie Jun‐dan , Zhang Tong‐tong , Zhang Ling , Xu Xiao‐yu , Shan Zhe , Liu Hong , Cen Jian‐nong , Liu Dan‐dan , Pan Jin‐lan , Lu Da‐ru , Chen Jia , Xu Yang , Zhang Ri , Wang Ying , Xue Sheng‐li , Miao Miao , Han Yue , Tang Xiao‐wen , Qiu Hui‐ying , Sun Ai‐ning , Huang Jin‐yan , Dai Hai‐ping , Wu De‐pei , Chen Su‐ning 
Published: October 2022

AbstractMixed phenotype acute leukemia (MPAL) is a subtype of leukemia in which lymphoid and myeloid markers are co‐expressed. Knowledge regarding the genetic features of MPAL is lacking due to its rarity and heterogeneity. Here, we applied an integrated genomic and transcriptomic approach to explore the molecular characteristics of 176 adult patients with MPAL, including 86 patients with T‐lymphoid/myeloid MPAL (T/My MPAL‐NOS), 42 with Ph+ MPAL, 36 with B‐lymphoid/myeloid MPAL (B/My MPAL‐NOS), 4 with t(v;11q23), and 8 with MPAL, NOS, rare types. Genetically, T/My MPAL‐NOS was similar to B/T MPAL‐NOS but differed from Ph+ MPAL and B/My MPAL‐NOS. T/My MPAL‐NOS exhibited higher CEBPA, DNMT3A, and NOTCH1 mutations. Ph+ MPAL demonstrated higher RUNX1 mutations. B/T MPAL‐NOS showed higher NOTCH1 mutations. By integrating next‐generation sequencing and RNA sequencing data of 89 MPAL patients, we defined eight molecular subgroups (G1–G8) with distinct mutational and gene expression characteristics. G1 was associated with CEBPA mutations, G2 and G3 with NOTCH1 mutations, G4 with BCL11B rearrangement and FLT3 mutations, G5 and G8 with BCR::ABL1 fusion, G6 with KMT2A rearrangement/KMT2A rearrangement‐like features, and G7 with ZNF384 rearrangement/ZNF384 rearrangement‐like characteristics. Subsequently, we analyzed single‐cell RNA sequencing data from five patients. Groups G1, G2, G3, and G4 exhibited overexpression of hematopoietic stem cell disease‐like and common myeloid progenitor disease‐like signatures, G5 and G6 had high expression of granulocyte‐monocyte progenitor disease‐like and monocyte disease‐like signatures, and G7 and G8 had common lymphoid progenitor disease‐like signatures. Collectively, our findings indicate that integrative genomic and transcriptomic profiling may facilitate more precise diagnosis and develop better treatment options for MPAL.
Aqueous in‐situ electrosynthesis and electrochromic performance of PEDOT:PSS/Reline film
Authors: Wu Wei , Zeng Hailan , Zhang Weiran , Zhang Weili , Jiang Haiyun , Wu Guohua , Li Ziyu , Wang Xiang , Huang Yiyang , Lei Zhiyong 
Published: October 2022

AbstractPoly(3,4‐ethylene dioxythiophene) (PEDOT) is a promising electrochromic material in many practical application, such as smart windows and displays. However, there are still difficulties in currently realizing green manufacturing, high coloration efficiency, and rapid response. Herein, in‐situ electrochemical polymerization of PEDOT:PSS/Reline films was suggested in aqueous solution. Deep eutectic solvents (DES) composed of choline chloride and urea (Reline) were employed as green solvents in reaction system and used as dopants for the PEDOT:PSS. The as‐prepared PEDOT:PSS/Reline films exhibited remarkable electrochromic properties, including great ion diffusion coefficient, fast reaction time (coloration response time was 1.4 s), prominent transmittance modulation (38%), high coloration efficiency (223 cm2/C) and excellent cyclic stability. Impressively, doping of Reline cannot only provide a green polymerization environment, but also significantly boost the electrochromic properties.
CrosslinkedPMIAultrafiltration membrane with enhanced permeability via incorporatingTMCmonomer
Authors: Gao Ling‐Lin , Li Ping‐Ping , Li Hua‐Xiang , Fang Yin‐Xin , Lin Yu‐Fei , Zhan Zi‐Ming , Xu Zhen‐Liang 
Published: October 2022

AbstractA trade‐off behavior is noteworthy between protein rejection and pure water flux (PWF) for ultrafiltration membranes; it is recommendable to increase flux without reducing selectivity. The poly (meta‐phenylene isophthalamide) (PMIA) ultrafiltration membrane was modified via incorporating 1,3,5‐benzene tricarboxylic chloride (TMC) to optimize the performance for the first time. Molecular dynamics (MD) simulation was applied to probe the mechanism of the effects of the concentrations of cosolvent LiCl and addition TMC on the dissolving process. It was turned out that a suitable concentration of TMC in the dope solution markedly enhanced the PWF (from 276.22 to 566.20 m−2 h−1 bar−1) with an increasing bovine serum albumin rejection (from 92.05% to 94.64%). Besides, the optimized membrane also possesses excellent anti‐fouling and mechanical performance. These improvements can be due to the crosslinking between PMIA and TMC and enlarged average pore diameter. This work broadens the application of PMIA and TMC in ultrafiltration and provides a novel methodology for PMIA modification.
Bioenergy research in Brazil: A bibliometric evaluation of the BIOEN research program
Authors: Souza Roney Fraga , Miranda Júlio Cesar de Carvalho , da Silva Júnior Jaim José , da Silveira José Maria 
Published: October 2022

AbstractThis article discusses the scientific production carried out by the largest bioenergy research program in Brazil, the São Paulo Research Foundation Bioenergy Research Program (BIOEN‐FAPESP), in the period from 2008 to 2019. The study draws on a list of BIOEN publications on the Web of Science (WoS) platform, containing over 1000 articles, grouped under ResearcherID H‐6149‐2012. The methods applied in the study were based on the information specific to each article and involved the construction of networks including authors, countries, research subjects, and direct citations. Communities were built based on network properties and their content was extracted from articles abstracts, titles and keywords, using text mining techniques. We also obtained quantitative measures for BIOEN scientific output. The analysis found that BIOEN produced relevant knowledge, and contributed to the emergence of new research areas in the bioenergy sector. Overall, BIOEN was decisive for the advancement of bioenergy research in Brazil, and resulted in the expansion of the knowledge base for ethanol production. © 2022 Society of Chemical Industry and John Wiley & Sons, Ltd.
Losing a child to adolescent cancer: A register‐based cohort study of psychotropic medication use in bereaved parents
Authors: Hovén Emma , Ljungman Lisa , Sveen Josefin , Skoglund Charlotte , Ljungman Gustaf , Ljung Rickard , Wikman Anna 
Published: October 2022

AbstractPurposeTo investigate the short‐ and long‐term risk of psychotropic medication use in parents who lose a child to cancer diagnosed in adolescence.MethodsThis is a Swedish nationwide register‐based study including 184 bereaved mothers and 184 bereaved fathers of 184 children diagnosed with cancer in adolescence. Logistic regression analyses, adjusted for sociodemographic characteristics and history of mental health problems, were performed to estimate risk of a prescription of psychotropic medication (anxiolytics, hypnotics/sedatives, antidepressants) in cancer‐bereaved parents from 1 year before to 5 years after the child's death, with a general population sample of non‐bereaved parents (n = 3291) as referents.ResultsAt the year of the child's death, 28%–36% of mothers and 11%–20% of fathers had a prescription of anxiolytics, hypnotics/sedatives or antidepressants. The corresponding percentages for non‐bereaved mothers and fathers were 7%–12% and 4%–7%, respectively. Compared to non‐bereaved mothers, bereaved mothers showed higher odds of prescriptions from 1 year before up to four (anxiolytics) and 5 years (hypnotics/sedatives and antidepressants) after the child's death. Bereaved fathers showed higher odds than non‐bereaved fathers of prescriptions from 1 year before up to the year of (anxiolytics and hypnotics/sedatives) and 1 year after (antidepressants) the child's death. No differences in odds between bereaved and non‐bereaved fathers were found at 2 years after the child's death. Being unmarried, born outside Sweden, and having a history of mental health problems were associated with higher odds of prescribed medications.ConclusionsIndicative of mental health problems of clinical importance, cancer‐bereaved parents had a higher prevalence of use of psychotropic medication. A decrease in medication use was evident with time, but still at 5 years after the child's death mothers displayed a higher use while fathers showed no difference to non‐bereaved fathers after 2 years.
Nodular hepatic lesion mimicking gallbladder carcinoma in myeloma
Authors: Takatsuka Keiko , Matsumoto Masanori , Takakuwa Teruhito 
Published: October 2022

AbstractAn 81‐year‐old man was diagnosed with nodular hepatic lesion of extramedullary plasmacytoma with the absence of FDG uptake. Doppler ultrasonography showed pulsations and abundant blood flow signals within the tumor. The blood flow was temporally reduced after daratumumab‐based induction therapy; however, the tumor rapidly re‐expanded with blood reflow.
Massive anorectal abscess caused by rectal cancer
Authors: Hirata Risa , Tago Masaki , Aihara Hidetoshi 
Published: October 2022

AbstractA 66‐year‐old man with perianal pain was found to have a tender erythematous mass on the left side of the anus. Thoracoabdominal computed tomography with contrast enhancement showed a massive anorectal abscess extending from the rectum to the perianal area. The final diagnosis was anorectal abscess caused by rectal cancer.
Case report on psychogenic nonepileptic seizures: A series of unfortunate events
Authors: Udofia Aniebiot‐Abasi , Rocke Tamarie 
Published: October 2022

AbstractPsychogenic nonepileptic seizures, also called Functional Seizures, are a highly disabling form of Functional Neurological Disorder. The diagnosis of PNES could be missed in clinical scenarios where patients exhibit concurrent musculoskeletal/neurological findings. Characterization of convulsions and judicious use of diagnostics are equally valuable in establishing the diagnosis.
A Closed Loop Wastewater Biorefinery Based on the Recently Introduced SHEFROL Reactor and Two Freely Available Macrophytes
Authors: Tabassum‐Abbasi  , Patnaik Pratiksha , Abbasi Shahid Abbas 
Published: October 2022

AbstractWith an objective to develop a closed loop wastewater biorefinery, the performance of two free floating aquatic weeds water hyacinth (Eichhornia crassipes, Mart, Solms) and salvinia (Salvinia molesta, Mitchell) is explored when either is used as the main bioagent for treating sewage in “sheet flow root level” (SHEFROL) bioreactors. Both the macrophytes prove to be easy to propagate and maintain while they are able to help in achieving significant primary, secondary, and tertiary treatment steps of greywater in a single step. Water hyacinth is able to remove suspended solids, chemical oxygen demand (COD), biological oxygen demand (BOD), total Kjeldahl nitrogen, soluble phosphorous, zinc, copper, nickel, and manganese to the average extents of 81%, 79%, 43%, 41%, 40%, 36%, 34%, and 29%, respectively. The reduction in COD and BOD levels achieved by salvinia is marginally lesser than by water hyacinth but in terms of the removal of other pollutants, the performance of salvinia is comparable to that of water hyacinth. It is possible to convert the dead or harvested plants to organic fertilizer thus making it a closed‐loop system with no waste of its own.
Never stop wondering: When cells become PAP‐art on the slides
Authors: Lombardo Vittoria , Cartesio Stefania , Fadda Guido , Rossi Esther Diana 
Published: October 2022

AbstractThe project named Victoria’s cells was created to train health care personnel, especially in low‐income countries. This innovative approach is designed to associate benign and malignant cellular images and/or patterns with a range of shapes and color shades to evoke animals, common objects, and colorful aquariums. The project makes use of familiar images to capture the viewer’s interest as an aid for cytological interpretation. Cervicovaginal cytology is processed with conventional and liquid‐based cytology. The images are visually compelling to highlight the importance of studying cells and their diagnostic significance. Infectious diseases as well as malignant cells are thereby easily recognized. The pictures are organized into different sections, including Victoria’s zoo, Victoria’s fantasy, and malignant mockery. Branching mycelia resemble a starfish; squamous metaplasia recalls a sea turtle’s shell. Among others, different patterns of endometrial, endocervical, and squamous cells can resemble fish tanks populated by cells with the shapes of pufferfish, anglerfish, whales, scorpions, and garfish. The sea transitions to the earth, with a sly cat, a little elephant, a dog, and a koala. Other cellular preparations resemble a gymnast, a geisha, and a plunging diver as well as hummingbirds, a heron, a water lily, and a peony. The malignant mockery section is composed of squamous intraepithelial lesion patterns that resemble monsters, eyes, a foul tongue, eagles, and feathers. In conclusion, the recognition of visual images can make the study of cytology simpler and more enjoyable and serve the final objectives of prevention and cure.
Combining sodium MRI, proton MR spectroscopic imaging, and intracerebral EEG in epilepsy
Authors: Azilinon Mikhael , Makhalova Julia , Zaaraoui Wafaa , Medina Villalon Samuel , Viout Patrick , Roussel Tangi , El Mendili Mohamed M. , Ridley Ben , Ranjeva Jean‐Philippe , Bartolomei Fabrice , Jirsa Viktor , Guye Maxime 
Published: October 2022

AbstractWhole brain ionic and metabolic imaging has potential as a powerful tool for the characterization of brain diseases. We combined sodium MRI (23Na MRI) and 1H‐MR Spectroscopic Imaging (1H‐MRSI), assessing changes within epileptogenic networks in comparison with electrophysiologically normal networks as defined by stereotactic EEG (SEEG) recordings analysis. We applied a multi‐echo density adapted 3D projection reconstruction pulse sequence at 7 T (23Na‐MRI) and a 3D echo‐planar spectroscopic imaging sequence at 3 T (1H‐MRSI) in 19 patients suffering from drug‐resistant focal epilepsy who underwent presurgical SEEG. We investigated 23Na MRI parameters including total sodium concentration (TSC) and the sodium signal fraction associated with the short component of T2* decay (f), alongside the level of metabolites N‐acetyl aspartate (NAA), choline compounds (Cho), and total creatine (tCr). All measures were extracted from spherical regions of interest (ROIs) centered between two adjacent SEEG electrode contacts and z‐scored against the same ROI in controls. Group comparison showed a significant increase in f only in the epileptogenic zone (EZ) compared to controls and compared to patients' propagation zone (PZ) and non‐involved zone (NIZ). TSC was significantly increased in all patients' regions compared to controls. Conversely, NAA levels were significantly lower in patients compared to controls, and lower in the EZ compared to PZ and NIZ. Multiple regression analyzing the relationship between sodium and metabolites levels revealed significant relations in PZ and in NIZ but not in EZ. Our results are in agreement with the energetic failure hypothesis in epileptic regions associated with widespread tissue reorganization.
Aortic regurgitation: A multimodality approach
Authors: Siani Agnese , Perone Francesco , Costantini Pietro , Rodolfi Sara , Muscogiuri Giuseppe , Sironi Sandro , Carriero Serena , Pavon Anna Giulia , van der Bilt Ivo , van Rosendael Philippe , Broekhuizen Lysette , Teske Arco , Cramer Maarten Jan , Guglielmo Marco 
Published: October 2022

AbstractAortic regurgitation (AR) is a common valvular pathology. Multimodality noninvasive cardiovascular imaging is routinely used to assess the mechanism of AR, degree, and its hemodynamic impact on the cardiovascular system. Collecting this information is crucial in establishing the prognosis and in guiding patient management and follow‐up. While echocardiography remains the primary test to assess AR, a comprehensive assessment of this valvulopathy can be obtained by combining the information from different techniques. This state‐of‐the‐art review is intended to provide an update ed overview of the applications, strengths, and limits of transthoracic echocardiography, cardiac magnetic resonance, and cardiac computed tomography in patients with AR.
Role of different echocardiographic modalities in the assessment of microvascular function in women with ischemia and no obstructive coronary arteries
Authors: Jovanovic Ivana , Tesic Milorad , Djordjevic‐Dikic Ana , Giga Vojislav , Beleslin Branko , Aleksandric Srdjan , Boskovic Nikola , Petrovic Olga , Marjanovic Marija , Vratonjic Jelena , Paunovic Ivana , Ivanovic Branislava , Trifunovic‐Zamaklar Danijela 
Published: October 2022

AbstractThis review summarizes current knowledge about echocardiographic modalities used to assess microvascular function and left ventricular (LV) systolic function in women with ischemia and no obstructive coronary arteries (INOCA). Although the entire pathophysiological background of this clinical entity still remains elusive, it is primarily linked to microvascular dysfunction which can be assessed by coronary flow velocity reserve. Subtle impairments of LV systolic function in women with INOCA are difficult to assess by interpretation of wall motion abnormalities. LV longitudinal function impairment is considered to be an early marker of subclinical systolic dysfunction and can be assessed by global longitudinal strain quantification.
Clinical prediction of magnetic resonance image compilation in patients with mild cognitive impairment
Authors: Sui Haijing , Yang Juan , Yan Chenggong 
Published: October 2022

AbstractThis study aims to investigate the clinical prediction of magnetic resonance image compilation (MAGiC) and magnetic resonance image (MRI) in early diagnosis of the patients with mild cognitive impairment. This study is a retrospective randomized controlled clinical trial, and all patients are divided into following two groups: experiment group and control group. Patients in the experiment group are detected by MAGiC, and patients in the control group are detected by MRI; the clinical material from the two groups of patients with MCI are collected, and then Wechsler Memory Scale‐Logical Memory (WMS‐LM) and Mini‐Mental State Examination (MMSE) are recorded by follow‐up. Images by MAGiC have higher accuracy and definition compared with those by MRI. WMS‐LM score and MMSE score in the experiment group are significantly better than those in the control group. We can conclude that MAGiC is a promising way to evaluate the clinical prediction in patients with MCI.
Coexistence of TEMPI syndrome and leukocytoclastic vasculitis successfully treated with autologous stem cell transplantation
Authors: Nappi Davide , Tauber Martina , Sykes David 
Published: October 2022

AbstractThe TEMPI syndrome is a very rare paraneoplastic syndrome associated with plasma cell dyscrasia and monoclonal gammopathy. First described in 2011, the pathophysiology of TEMPI syndrome is still unknown. Essential for diagnosis is to recognize the five clinical findings: telangiectasias, erythrocytosis and elevated serum erythropoietin, monoclonal gammopathy, perinephric fluid collection, and intrapulmonary shunting. Here we report a case of a woman with the coexistence of TEMPI and leukocytoclastic vasculitis, shedding light on a possible common inflammatory pathway involved in the pathogenesis of the syndrome.
The Value of Contrast‐Enhanced Ultrasound in the Detection of Sentinel Lymph Nodes in Malignant Melanoma
Authors: Deng Xiao‐hong , Du Zhong‐shi , Wu Zhou‐gui , Chen Yu , Wu Xian‐yi , Tang Li‐na 
Published: October 2022

ObjectiveTo evaluate the location and characterization value of contrast‐enhanced ultrasound (CEUS) in the detection of sentinel lymph nodes (SLNs) in malignant melanoma.MethodsSLNs and the lymph node network were tracked by subcutaneous injection of ultrasonic contrast agent around the tumor and preoperative localization, and qualitative analyses were performed. The SLNs were also detected by the intraoperative subcutaneous injection of carbon nanoparticles, and the findings were compared with lymph nodes located by CEUS. The accuracy of the preoperative lymph node identification was evaluated by the results of postoperative pathology, which served as the gold standard of detection.ResultsIn 47 patients with malignant melanoma, the mean number of SLNs detected by CEUS was 1.72 ± 0.10, while that by carbon nanoparticle administration it was 1.79 ± 1.07 (P = .371 > .05). Seven cases of lymph node metastasis were detected by CEUS, with a sensitivity of 70.0%, specificity of 97.3%, positive predictive value of 87.5%, negative predictive value of 92.3%, and accuracy of 91.5%. There was high consistency between the findings of CEUS and pathology in differentiating benign and malignant lymph nodes (kappa = 0.726, χ2 = 25.243, P < .001).ConclusionsCEUS can localize and differentiate SLNs in malignant melanoma, and thus, may potentially guide clinical treatment in the future.