bluuebunny/crossref_metadata_2025_split huggingface dataset:
PENDAMPINGAN ORANG TUA KEPADA ANAK DALAM MENCEGAH DAMPAK NEGATIF DARI GADGET
Authors: Tasya Muthia Rana , Masitoh Siti 
Published: November 2022

Tujuan dari penelitian ini adalah untuk mengetahui bagaimana pendampingan orang tua kepada anak melalui komunikasi interpersonal dalam pencegahan dampak negatif dari gadget. Metode yang digunakan oleh peneliti adalah metode deskriptif kualitatif dimana peneliti melakukan observasi, wawancara, dan dokumentasi terhadap enam informan yang dipilih secara acak, serta pakar yang dianggap ahli dalam penelitian ini. Teori yang digunakan adalah teori penetrasi sosial dan teori determinisme teknologi. Paradigma yang digunakan adalah paradigma konstruktivisme. Hasil penelitian menunjukan bahwa pendampingan orang tua kepada anak juga harus terjadi melalui komunikasi, yaitu komunikasi interpersonal. Dari kelima elemen komunikasi interpersonal yaitu keterbukaan, empati, dukungan, rasa positif, dan kesetaraan atau kesamaan, keenam informan cenderung mengawali hubungan interpersonal dengan anaknya melalui tahap keterbukaan terlebih dahulu. Dengan masing – masing memiliki keterbukaannya, dari hal tersebut dapat membangun komunikasi interpersonal yang baik antara orang tua dan anak. Ketika anak-anak memiliki edukasi dan lingkungan yang baik, maka dalam hal penggunaan gadget pun akan disertai dengan kedisiplinan dalam kesehariannya. Kata kunci: Komunikasi Interpersonal, Orang Tua dan Anak, Gadget
KORELASI ANTARA TINGKAT PARTISIPASI MASYARAKAT DENGAN PEMANFAATAN PROGRAM PAMSIMAS DI DESA SUNGAI PASIR PUTIH KECAMATAN KELAYANG KABUPATEN INDRAGIRI HULU
Authors: Triani Melda , Ginda Ginda 
Published: November 2022

ABSTRAKPenelitian ini dilatarbelakangi oleh adanya program PAMSIMAS yang didirikan di Desa Sungai Pasir Putih Kecamatan Kelayang Kabupaten Indragiri Hulu. Program PAMSIMAS (Penyediaan Air Minum dan Sanitasi Berbasis Masyarakat) yang dirumuskan untuk dibangun di Dusun I Desa Sungai Pasir Putih yang kesulitan mendapatkan air bersih karena daratan yang tinggi. Penelitian ini bertujuan untuk melihat seberapa besar tingkat partisipasi masyarakat terhadap pemanfaatan Program PAMSIMAS di Desa sungai Pasir Putih. Metode penelitian yang digunakan adalah metode kuantitatif dengan teknik analisa data korelasi pearson product moment (PPM) menggunakan alat bantu SPSS 16. Teknik pengumpulan data yang digunakan observasi, kuisioner dan dokumentasi. Populasi dalam penelitian ini adalah keluarga yang menjadi sasaran penerima manfaat Program PAMSIMAS ini yang berjumlah 56 KK. Teknik pengambilan sampel menggunakan total sampling, teknik pengambilan sampel dimana jumlah sampel sama dengan populasi. Hasil penelitian menunjukkan terdapat tingkat partisipasi masyarakat terhadap pemanfaatan program PAMSIMAS yang signifikan dengan nilai koefisien korelasi sebesar 36,1% dan berada pada rata-rata 0,60-0,799. Hal ini berarti Variabel X berpengaruh pada Variabel Y yang berarti kuat pengaruhnya. Maka peneliti menyimpulkan tingkat partisipasi masyarakat memiliki pengaruh yang signifikan terhadap pemanfaatan program PAMSIMAS di Desa Sungai Pasir Putih Kecamatan Kelayang Kabupaten Indragiri Hulu.Kata Kunci : Tingkat Partisipasi, Pemanfaatan, Program PAMSIMAS
Experimental Endoscope Rotitome-G: A pixel-by-pixel erasure microsurgical endoscopic sarcotome for resection of soft tissue tumours in closed body cavities
Authors: Gandhi Harjeet Singh 
Published: November 2022

Background: The procedure of minimal access to the brain through the nose is an ancient practice. However, endoscopic entry via a burr hole has recently gained significant traction in the practice of neurosurgery. High-resolution endoscopic images are possible with limited admittance of accessory tools and instruments. Although brain tissue can be removed easily with a suction device, but it will be uncontrolled ‘excision’. The Rotitome-G is a precision micro-endoscopic target access surgical instrument. It has several accessories for intraoperative assessment and precise removal of the soft tissue lesions pixel-by-pixel within a closed body cavity through a single portal.
Objective: This preliminary theoretical research study on Rotitome-G is transition to experimental cadaveric and clinical studies. It describes the construction and mechanics of this newly conceptualized robot-assisted microsurgical endoscope. The design includes precise excision at the pixel and microscopic level and removes tissue debris under computer-aided navigation and direct instrument vision. Currently, the primary objective is to interest both the neurosurgeons and biomedical engineers, hence its contents are diverse resulting in an extended text.
Methodology: The study provides the basics of computer vision techniques and neuronavigation to establish the function and application of the Rotitome-G. The structure and kinematics of the animalcule Rotifer have been considered followed by the construction of Rotitome-G. For a better understanding of intracranial tumour excision, the article examines the role of intra-operative imaging, biomechanics of brain tissue, and brain shift to better understand the principles of this newly conceived microsurgical instrument. The functional capabilities of the instrument have been putatively demonstrated by describing the excision of a glioblastoma.
Conclusion: It is expected that the key design of Rotitome-G would meet the goal of neurosurgical resection by excising maximum amount of pathological tissue. Direct microscopic resection will prevent damage to the eloquent areas to improve the prognosis by limiting neurological morbidity. Clinical validity of the Rotitome -G remains to be determined.
Predictors of thrombosis development in the acute period of stroke
Authors: Chazov S. A. , Mekhryakov S. A. , Pavlova A. V. , Kulesh A. A. , Syromyatnikova L. I. , Karakulova J. V. , Shestakov V. V. , Astanin P. A. 
Published: November 2022

Introduction. According to foreign studies, the frequency of asymptomatic deep vein thrombosis (DVT) in the acute period of stroke varies from 10 to 75%, clinically obvious — from 2 to 10%. DVT is a life-threatening complication as it can lead to the development of pulmonary embolism (PE).Purpose of the study: to identify predictors of DVT development in the lower extremities in patients with stroke according to the registry of the Regional Vascular Center (RVC).Materials and methods. 100 patients with stroke who were admitted to the wards/intensive care unit of the RVC from November to December 2021 were examined. In addition to the standard examination, all patients underwent duplex scanning of the veins of the lower extremities upon admission and on the 7th day of inpatient treatment.Results. The incidence of DVT was 13%. Compared with patients without DVT, patients with thrombosis were characterized by higher median values of age (77 vs 67 years, p = 0.015), time from stroke to hospital admission (24 vs 5 hours, p = 0.026), stroke severity by NIHSS score at admission (16 vs 5 points, p = 0.006) and completion of the first stage of treatment (10 vs 3 points, p = 0.010), movement disorders in the leg according to the Medical Research Council scale (4 vs 1 points, p = 0.011) and IMPROVE-VTE scales (4 vs 2 points, p < 0.001). In half of patients with DVT, thrombosis occurred already at admission to the hospital, in the rest it occurred during treatment. In a quarter of patients, thrombosis involved the proximal veins and was complicated by the development of PE in one patient, the rest had distal DVT. In all cases, DVT developed in the paretic limb. In all patients, thrombosis was initially regarded as asymptomatic and was diagnosed only by duplex scanning of the veins. The most significant risk factors for developing DVT in the acute period of stroke were age 64 years and over (OR = 8.1), stroke severity on the NIHSS scale at admission of 6 points and above (OR = 5.6), time to admission from 10 hours or more (OR = 3.8), leg strength not more than 3 points (OR = 4.5) and an IMPROVE-VTE score of 3 points or more (OR = 9.5). When building a logistic regression model using the identified risk factors, accuracy values were obtained equal to 83% and 85% for the training and test samples, respectively.Conclusion. DVT is observed in 13% of patients in the acute period of stroke and is associated with the age of patients, the severity of stroke and movement disorders, the time from the development of symptoms to hospital admission, and the risk of venous thromboembolic complications according to the IMPROVE-VTE scale.
Seroprevalence of Scrub Typhus in Patients Attending Dhulikhel Hospital, Kavre
Authors: Madhup S. K. , Shrestha R. , Katuwal N. , Magar S. R. , Shrestha S. , Bhandari S. , Tamrakar D. 
Published: November 2022

Background Scrub typhus is a largely ignored tropical disease and a leading cause of undifferentiated febrile illness. It is caused by Orientia tsutsugamushi. Scrub Typhus is frequently observed in South Asian countries. However, clear epidemiological information of this disease is lacking in case of Nepal. Nepal has shown steady increase in cases of Scrub Typhus since 2015. The epidemiological data related to this disease would support the decision making and surveillance design for early outbreak detection and immediate responses including prevention and treatment of scrub typhus in Nepal.
Objective To understand prevalence of Scrub Typhus in subjects who had visited outpatient department at Dhulikhel Hospital.
Method In this study, we have studied antibody test data (n=784) for Scrub Typhus from 2019 to 2021. The tests were performed on serum samples of patients who had visited OPD at Dhulikhel Hospital with fever lasting more than 5 days. The kit used in analysis was Scrub Typhus Detect™ IgM ELISA Kit from InBios International.
Result Out of the total subjects (n=784), 133 were positive (16.9%) for IgM antibody of Scrub Typhus. The positivity in female (18.6%) was higher than the male subjects (15.3%). The positivity rate was variable among the different age groups, with highest positivity for age group 0-14 years (25%). The seasonal variation was also observed among the seropositive cases.
Conclusion Scrub Typhus being a neglected tropical disease has high prevalence. It can be postulated that female subjects and subjects of age group 0-14 years are vulnerable to the infection with Scrub Typhus. There is need to increase the surveillance of Scrub Typhus to add the knowledge for diagnosis and treatment.
Assessment of denosumab treatment efficiency in patients with giant cell tumor of bone using CT and MRI (own results and literature review)
Authors: Fedorova A. V. , Spirina O. G. , Tararykova A. A. , Sushentsov E. A. , Kochergina N. V. , Bludov A. B. , Shchipakhina Ya. A. , Batyrova G. S. 
Published: November 2022

Relevance. Giant cell tumor of the bone is most common in people of working age, which determines the high social significance of successful treatment of this category of patients. The main method of treatment is surgical. Currently, the targeted drug denosumab has appeared, the criteria for evaluating the effectiveness of therapy for which, according to the data of radiation methods, are not clearly defined.Target. To analyze and compare the possibilities of CT and MRI in evaluating the effectiveness of denosumab therapy for giant cell tumors.Materials and methods. The data of CT and MRI of 19 patients with giant cell tumor of tubular bones on the background of denosumab therapy were analyzed.Results. Before treatment, the extraosseous component was determined in 57.9 % (n = 11), after – 31.6 % (n = 6). The decrease occurred in 100 %, the disappearance – in 45 % (n = 11) of cases. The thickness of the extraosseous component before treatment ranged from 4 to 43 mm (Me = 15 mm), after treatment it ranged from 0 to 30 mm (Me = 8 mm). The decrease occurred in the range from 4 to 14 mm (M ± SD = 7 ± 4 mm). In 100 % of cases, a sclerotic rim appeared, the thickness of which after treatment ranged from 1 to 5 mm (Me = 3 mm). In the structure of the tumor, fibrosis occurred in 95 % (n = 18), a decrease in the cystic component occurred in 82 % (n = 9) of cases. Perifocal changes decreased in 100 % of cases. In 100 %, the average tumor density increased. The mean tumor density before treatment ranged from 27 to 65 HU (M ± SD = 42 ± 11 HU), after treatment it ranged from 69 to 500 HU (Me = 150 HU). The increase in density occurred in the range from 41 to 454 HU (Me = 101 HU). All differences are statistically significant (p < 0.05).Conclusions. Evaluation of effectiveness with the definition of quantitative and qualitative indicators is possible according to the data of both CT and MRI; with CT, changes are recorded longer, and more indicators available for quantitative measurement are determined.
A facile and efficient synthesis approach of salidroside esters by whole-cell biocatalysts in organic solvents
Authors: Yang Rongling , Wang Yu , Zhao Xiangjie , Tong Zheng , Zhu Qianlin , He Xiaoxi , Wang Zhaoyu , Luo Hongzhen , Fang Fang 
Published: November 2022

Salidroside, the main bioactive compound isolated from the plant source of Rhodiola rosea L, possesses broad-spectrum pharmacological activities, but suffers from the low cell membranes permeability and alimentary absorption due to its high polarity. Therefore, a whole-cell catalytic strategy for the synthesis of salidroside esters was explored to improve its lipophilicity. The results showed that Aspergillus oryzae demonstrated the highest biocatalytic activity among the microbial strains tested. For the synthesis of salidroside caprylate, the optimum conditions of reaction medium, Aspergillus oryzae amount, molar ratio of vinyl caprylate to salidroside and reaction temperature were acetone, 30 mg/ml, 10°C and 40°C, respectively. Under these conditions, the initial reaction rate was 15.36 mM/h, and substrate conversion and regioselectivity all reached 99%. Moreover, the results indicated that although various 6′-monoesters derivatives of salidroside were exclusively obtained with excellent conversions (96%–99%), the reaction rate varied greatly with different chain-length acyl donors. This study details an efficient and cost-effective biocatalytic approach for the synthesis of salidroside esters by using Aspergillus oryzae as a catalyst for the first time. Considering the whole cell catalytic efficiency and operational stability, this strategy may provide a new opportunity to develop green industrial processes production for ester derivatives of salidroside and its analogues.
Monitoring diacylglycerols in biofluids by non-isotopically paired charge derivatization combined with LC-MS/MS
Authors: Liu Yang-Dan , Liu Hua-Jun , Gong Guan-Wen 
Published: November 2022

Diacylglycerols (DAGs) are important lipid mediators in cellular signaling transduction and metabolism. Imbalanced production or consumption of DAGs has a negative impact on the physiological functions of the body. However, comprehensive monitoring of structurally diverse DAGs remains a daunting task due to the rapid metabolism and ion suppression characteristics in biofluids. These bottlenecks call for developing a method that enables sensitive quantification of DAGs in biological sample. In this work, a straightforward charge derivatization strategy was developed to insert a series of structure analogs charge label, i.e., N, N-dimethylglycine (DMG) and N, N-dimethylalanine (DMA), on the free hydroxyl group of the DAGs. Owing to the existence of tertiary amino groups in charge label, the mass spectrometry ionization response of the derivatized DAGs was significantly increased in comparison with traditional metal ion adducts. After charge derivatization, the specific neutral loss diagnostic ions (DMG, 103 Da and DMA, 117 Da) were captured by mass spectrometry. Then, the DMG/DMA-oriented paired multiple reaction monitoring methods based on the characteristic diagnostic ions of the derivatized DAGs have been developed as sensitive methods for the detection (detection limit = 16 aM) and quantification (quantification limit = 62.5 aM) of DAGs in serum. Moreover, the tagged 1,2-DAGs and 1,3-DAGs sn-isomers have been well separated on the reversed-phase column in combination with ultra-performance liquid chromatography. Finally, metabolic characterizations of the tagged DAGs were further explored in L-Arginine-induced acute pancreatitis mice and resveratrol treated model mice. The results indicated that 1,2-DAGs were increased in the serum of model mice relative to normal controls and resveratrol significantly altered this metabolic abnormality. The currently established DMG/DMA-oriented paired charge derivatization strategy is promising for depicting DAGs changes more accurately in metabolic studies of lipid-related diseases and accurately evaluating drug treatment strategies.
Elevated hypertriglyceridemia and decreased gallstones in the etiological composition ratio of acute pancreatitis as affected by seasons and festivals: A two-center real-world study from China
Authors: He Wenhua , Wang Gang , Yu Bingjun , Xia Liang , Zhu Yong , Liu Pi , Chen Hua , Kong Rui , Zhu Yin , Sun Bei , Lu Nonghua 
Published: November 2022

ObjectiveThe purpose of this study was to observe the annual variation in the etiology of acute pancreatitis (AP) and its relationship with seasons and festivals.MethodsFrom 2011 to 2017, 5146 adult patients with AP were studied, including 4110 patients from the First Affiliated Hospital of Nanchang University (South center) and 1036 patients from the First Affiliated Hospital of Harbin Medical University (North center). We analyzed the overall annual variation in the etiology of AP and then compared the differences in etiology between the two regions, as well as the effects of seasons and festivals on the etiology of AP.ResultsGallstones, hypertriglyceridemia (HTG) and alcohol were the top three etiologies of AP. Gallstone AP showed a downward trend (P&lt;0.001), and HTG-AP and alcohol AP showed an upward trend (both P&lt;0.01). Among the etiologies of AP, gallstones and HTG were affected by seasons and festivals. The composition ratio of HTG-AP increased, while gallstone AP decreased in winter and in months with long holidays (all P&lt;0.01). The composition ratio of gallstone AP in the south center was higher than that in the north center (59.5% vs. 49%), especially in summer (62.9% vs. 44.0%) and autumn (61.5% vs. 45.7%, all P&lt;0.001).ConclusionsThe composition ratio of HTG-AP increased while gallstone AP decreased in the past 7 years, and they were affected by seasons and festivals.
A coarse-to-fine and automatic algorithm for breast diagnosis on multi-series MRI images
Authors: Xue Hongwei , Qian Guangwu , Wu Xiaofen , Gao Yan , Yang Hongguang , Liu Mingqian , Wang Lei , Chen Renfei , Wang Peijun 
Published: November 2022

IntroductionEarly breast carcinomas can be effectively diagnosed and controlled. However, it demands extra work and radiologist in China often suffer from overtime working due to too many patients, even experienced ones could make mistakes after overloaded work. To improve the efficiency and reduce the rate of misdiagnosis, automatic breast diagnosis on Magnetic Resonance Imaging (MRI) images is vital yet challenging for breast disease screening and successful treatment planning. There are some obstacles that hinder the development of automatic approaches, such as class-imbalance of samples, hard mimics of lesions, etc. In this paper, we propose a coarse-to-fine algorithm to address those problems of automatic breast diagnosis on multi-series MRI images. The algorithm utilizes deep learning techniques to provide breast segmentation, tumor segmentation and tumor classification functions, thus supporting doctors' decisions in clinical practice.MethodsIn proposed algorithm, a DenseUNet is firstly employed to extract breast-related regions by removing irrelevant parts in the thoracic cavity. Then, by taking advantage of the attention mechanism and the focal loss, a novel network named Attention Dense UNet (ADUNet) is designed for the tumor segmentation. Particularly, the focal loss in ADUNet addresses class-imbalance and model overwhelmed problems. Finally, a customized network is developed for the tumor classification. Besides, while most approaches only consider one or two series, the proposed algorithm takes in account multiple series of MRI images.ResultsExtensive experiments are carried out to evaluate its performance on 435 multi-series MRI volumes from 87 patients collected from Tongji Hospital. In the dataset, all cases are with benign, malignant, or both type of tumors, the category of which covers carcinoma, fibroadenoma, cyst and abscess. The ground truths of tumors are labeled by two radiologists with 3 years of experience on breast MRI reporting by drawing contours of tumor slice by slice. ADUNet is compared with other prevalent deep-learning methods on the tumor segmentation and quantitative results, and achieves the best performance on both Case Dice Score and Global Dice Score by 0.748 and 0.801 respectively. Moreover, the customized classification network outperforms two CNN-M based models and achieves tumor-level and case-level AUC by 0.831 and 0.918 respectively.DiscussionAll data in this paper are collected from the same MRI device, thus it is reasonable to assume that they are from the same domain and independent identically distributed. Whether the proposed algorithm is robust enough in a multi-source case still remains an open question. Each stage of the proposed algorithm is trained separately, which makes each stage more robust and converge faster. Such training strategy considers each stage as a separate task and does not take into account the relationships between tasks.
Immunosuppressive environment in response to androgen deprivation treatment in prostate cancer
Authors: Qin Caipeng , Wang Jing , Du Yiqing , Xu Tao 
Published: November 2022

RationaleTo invest the role of androgen deprivation therapy (ADT) on the tumor immune microenvironment of prostate cancer.MethodsHere we have profiled the transcriptomes of 19,227 single cells from 4 prostate tumors, including two cases who received ADT. To validated the single-cell analysis we use another group of patients receiving neoadjuvant ADT.ResultsAfter receiving ADT treatment, the killing effect of prostate cancer immune cells on tumors is weakened, the interaction between immune cells and tumor cells is weakened, and the proportion of immunosuppressive cells Myeloid-derived suppressor cell (MDSC) and Regulatory T cells (Treg) cells increases.ConclusionsOur results highlight that ADT induces immunosuppressive in the prostate tumor microenvironment. These data have important implications for combining ADT with immunotherapy.