bluuebunny/crossref_metadata_2025_split huggingface dataset:
Influence of loading and aging on the fracture strength of an injection‐molded two‐piece zirconia implant restored with a zirconia abutment
Authors: Kohal Ralf‐Joachim , von Schierholz Christopher , Nold Julian , Spies Benedikt C. , Adolfsson Erik , Vach Kirstin , Burkhardt Felix 
Published: November 2022

AbstractObjectiveTo investigate the fracture strength and potential phase transformation of an injection‐molded two‐piece zirconia implant restored with a zirconia abutment after loading and/or aging.MethodsThirty‐two two‐piece zirconia implants (4.0 mm diameter) restored with zirconia abutments were embedded according to ISO 14801 and divided into four groups (n = 8/group): Three groups were either exclusively hydrothermally treated (group HT; 85°C), dynamically loaded (group DL; 107 cycles; 98 N), or subjected to both treatments simultaneously (group DL/HT). One group remained untreated (group 0). A sample from each group was cross‐sectioned and examined by scanning electron microscopy for possible crystal phase transformation. The remaining samples were then loaded to fracture in a static loading test. A one‐way ANOVA was used for statistical analyses.ResultsDuring dynamic loading, three implants of group DL and six implants of group DL/HT fractured at a load of 98 N. The fracture strength of group DL/HT (108 ± 141 Ncm) was significantly reduced compared to the other groups (group 0: 342 ± 36 Ncm; HT: 363 ± 49 Ncm; DL: 264 ± 198 Ncm) (p < .05). Fractures from group 0 and HT occurred at both implant and abutment level, whereas implants from group DL and DL/HT fractured only at implant level. A shallow monoclinic transformation zone of approximately 2 μm was observed following hydrothermal treatment.ConclusionsWithin the limitations of this study, it can be concluded that dynamic loading and the combination of loading and aging reduced the fracture strength of the implant abutment combination. Hydrothermal treatment caused a shallow transformation zone which had no influence on the fracture strength.
Work‐related and personal risk factors for occupational contact dermatitis: A systematic review of the literature with meta‐analysis
Authors: Schütte Marijke G. , Tamminga Sietske J. , de Groene Gerda J. , Kezic Sanja , van der Molen Henk F. 
Published: November 2022

AbstractThe objective of this review is to identify work‐related and personal risk factors for contact dermatitis (CD), and assess their association with this frequently occurring occupational disease. A systematic review of the literature from 1990 to June 2, 2020, was conducted using Medline and Embase. Prospective cohort and case–control studies were included, and meta‐analyses were conducted when feasible. Quality of evidence was assessed using the Grading of Recommendations, Assessment, Development, and Evaluation. Twenty‐nine studies were identified, comprising 26 study populations and with a total of 846 209 participants investigating 52 risk factors for CD. Meta‐analyses were performed for five risk factors, all of them for irritant contact dermatitis (ICD). Moderate‐quality evidence was found for associations between wet work and ICD (OR: 1.56, 95%CI: 1.21–2.01). High‐quality evidence was found for the association between atopic dermatitis and ICD (OR: 2.44, 95%CI: 1.89–3.15). There was no evidence for an association between ICD and sex or history of hand dermatitis, respiratory and mucosal atopy. In conclusion, several work‐related and personal risk factors associated with CD were identified. Our data emphasize the need for the assessment of both, work‐related and personal, risk factors to prevent occupational CD.
Cancer patients with venous thromboembolism: Diagnostic and prognostic value of elevated D‐dimers
Authors: Koch Vitali , Martin Simon S. , Gruber‐Rouh Tatjana , Eichler Katrin , Mahmoudi Scherwin , Leistner David M. , Scholtz Jan‐Erik , Bernatz Simon , Puntmann Valentina O. , Nagel Eike , Booz Christian , D'Angelo Tommaso , Alizadeh Leona S. , Yel Ibrahim , Ziegengeist Nicole S. , Torgashov Katerina , Geyer Tobias , Hardt Stefan E. , Vogl Thomas J. , Gruenewald Leon D. , Giannitsis Evangelos 
Published: November 2022

AbstractBackgroundD‐dimer testing is known to have a high sensitivity at simultaneously low specificity, resulting in nonspecific elevations in a variety of conditions.MethodsThis retrospective study sought to assess diagnostic and prognostic features of D‐dimers in cancer patients referred to the emergency department for suspected pulmonary embolism (PE) and deep vein thrombosis (DVT). In total, 526 patients with a final adjudicated diagnosis of PE (n = 83) and DVT (n = 69) were enrolled, whereas 374 patients served as the comparative group, in which venous thromboembolism (VTE) has been excluded.ResultsFor the identification of VTE, D‐dimers yielded the highest positive predictive value of 96% (95% confidence interval (CI), 85–99) at concentrations of 9.9 mg/L and a negative predictive value of 100% at .6 mg/L (95% CI, 97–100). At the established rule‐out cut‐off level of .5 mg/L, D‐dimers were found to be very sensitive (100%) at a moderate specificity of nearly 65%. Using an optimised cut‐off value of 4.9 mg/L increased the specificity to 95% for the detection of life‐threatening VTE at the cost of moderate sensitivities (64%). During a median follow‐up of 30 months, D‐dimers positively correlated with the reoccurrence of VTE (p = .0299) and mortality in both cancer patients with VTE (p < .0001) and without VTE (p = .0008).ConclusionsAlthough D‐dimer testing in cancer patients is discouraged by current guidelines, very high concentrations above the 10‐fold upper reference limit contain diagnostic and prognostic information and might be helpful in risk assessment, while low concentrations remain useful for ruling out VTE.
The significance of partial migration for food web and ecosystem dynamics
Authors: Peller Tianna , Guichard Frédéric , Altermatt Florian 
Published: November 2022

AbstractMigration is ubiquitous and can strongly shape food webs and ecosystems. Less familiar, however, is that the majority of life cycle, seasonal and diel migrations in nature are partial migrations: only a fraction of the population migrates while the other individuals remain in their resident ecosystem. Here, we demonstrate different impacts of partial migration rendering it fundamental to our understanding of the significance of migration for food web and ecosystem dynamics. First, partial migration affects the spatiotemporal distribution of individuals and the food web and ecosystem‐level processes they drive differently than expected under full migration. Second, whether an individual migrates or not is regularly correlated with morphological, physiological, and/or behavioural traits that shape its food‐web and ecosystem‐level impacts. Third, food web and ecosystem dynamics can drive the fraction of the population migrating, enabling the potential for feedbacks between the causes and consequences of migration within and across ecosystems. These impacts, individually and in combination, can yield unintuitive effects of migration and drive the dynamics, diversity and functions of ecosystems. By presenting the first full integration of partial migration and trophic (meta‐)community and (meta‐)ecosystem ecology, we provide a roadmap for studying how migration affects and is affected by ecosystem dynamics in a changing world.
A spatiotemporal‐distributed deep‐learning framework for KPI estimation of chemical processes with cascaded reactors
Authors: Li Jiaxin , Li Yonggang , Feng Zhenxiang , Sun Bei , Long Shuang , Luo Yanting 
Published: November 2022

AbstractOnline and accurate estimation of key performance indicators (KPI) is the foundation for operational optimization of a chemical process. However, a chemical process usually consists of multiple reactors, and the factors influencing KPI are spatially distributed in the long process flow. In addition, due to the distinct time lags between KPI and each reactor, temporal relationships among KPI and its influence factors are a mixture of short‐term and long‐term relationships. In this regard, a deep distributed KPI estimator with a self‐attention mechanism is proposed in this paper. First, considering the process topology, a cascaded long short‐term memory network is developed to simulate the process topology and capture the short‐term effects. Then, to extract the long‐term dependencies, a de‐noise self‐attention layer is employed to model interactions of all the influence factors explicitly and dynamically. Lastly, the proposed method is compared with typical state‐of‐the‐art methods using real industrial data. The comparison results illustrate the performance and effectiveness of the proposed KPI estimation method.
Community‐based health literacy focused intervention for cervical cancer control among Black women living with human immunodeficiency virus: A randomized pilot trial
Authors: Han Hae‐Ra , Mendez Kyra J. W. , Perrin Nancy , Cudjoe Joycelyn , Taylor Gregory , Baker Dorcas , Murphy‐Stone Jeanne , Sharps Phyllis 
Published: November 2022

AbstractBackgroundHealth literacy plays an essential role in how individuals process health information to make decisions about health behaviours including cancer screening. Research is scarce to address health literacy as a strategy to improve cancer screening participation among women living with human immunodeficiency virus (HIV), particularly Black women who, despite the heavy burden of cervical cancer, report consistently low screening rates.AimTo assess the feasibility, acceptability and preliminary efficacy of a health literacy‐focused intervention called CHECC‐uP—Community‐based, HEalth literacy focused intervention for Cervical Cancer control—among women living with HIV.MethodsWe conducted a community‐based, single‐blinded randomized pilot trial. A total of 123 eligible women were enrolled and randomized to one of two conditions, control (i.e., cervical cancer brochure) or intervention (cervical cancer brochure plus 30–60 min health literacy‐focused education followed by monthly phone counselling and navigation assistance for 6 months). Study assessments were done at baseline, 3 and 6 months. The final analysis sample included 58 women who completed all data points and whose Papanicolaou (Pap) test status was confirmed by medical records.ResultsAll intervention participants who completed the programme would recommend the CHECC‐uP to other women living with HIV. However, adherence in the experimental conditions was low (49.6% attrition rate including 20 women who dropped out before the intervention began) due, in large part, to phone disconnection. Those who had received the intervention had a significantly higher Pap test rate compared to women in the control group at 6 months (50% vs. 21.9%, p = .025). Participation in the intervention programme was associated with improved health literacy and other psychosocial outcomes at 3 months but the trend was attenuated at 6 months.ConclusionsThe CHECC‐uP was highly acceptable and led to improved Pap testing rates among Black women living with HIV. Future research should consider addressing social determinants of health such as phone connectivity as part of designing a retention plan targeting low‐income Black women living with HIV.ImplicationsThe findings should be incorporated into a future intervention framework to fulfil the unmet needs of Black women living with HIV to facilitate their decision‐making about Pap test screening.Patient or Public ContributionNineteen community members including women living with HIV along with HIV advocates and care providers participated in four focus groups to develop cervical cancer screening decision‐relevant information and the health literacy intervention. Additionally, a community advisory board was involved to provide guidance in the general design and conduct of the study.
Propofol dose and efficacy of defibrillation testing during implantation of subcutaneous implantable cardioverter‐defibrillators: A retrospective, single center cohort study
Authors: Trolese Luca , Dall'Aglio Pietro Bernardo , Steinfurt Johannes , Gressler Alexander , Faber Thomas , Cipriani Alberto , Migliore Federico , Westermann Dirk , Hilgendorf Ingo , Jäckel Markus ,   Study Group
Published: November 2022

AbstractIntroductionDefibrillation testing (DFT) is recommended during subcutaneous implantable cardioverter‐defibrillator (S‐ICD) implantation. Previous studies analyzing the potential interference of propofol with defibrillation threshold are inconsistent. The purpose of this study was to analyze whether propofol affects DFT post S‐ICD placement.MethodsAll patients with S‐ICD implantation between 01/2017 and 11/2020 at the University Heart Center Freiburg were retrospectively analyzed. Two groups were generated depending on the success of the first shock during DFT. Implantation characteristics and dose of anesthetics were analyzed.ResultsIn 12 of the included 80 (15%) patients, first shock during DFT failed. The absolute dose of propofol was significantly higher in patients with first shock failure (median 653 mg [IQR 503–855]) compared to patients with first shock termination (376 mg [200–600]; p = 0.027). Doses of opioids and midazolam as well as type of anesthesia did not differ between the groups. A multivariable binary logistic regression analysis confirmed an independent association of first shock termination and propofol dose (per 100 mg: OR 0.73 (95% CI: 0.56–0.95); p = 0.021).ConclusionThere is an independent association of propofol dose and first shock failure in routine S‐ICD defibrillation testing.
High sodium diet intake and cardiovascular diseases: An attributable death study in Tianjin, China
Authors: Xue Xiao‐Dan , Li Wei , Xie Mei‐Qiu , Wang De‐Zheng , Li Dan‐Dan , Xin Peng , Zheng Wen‐Long , Jiang Guo‐Hong 
Published: November 2022

AbstractThere is clear evidence that high sodium intake is associated with many health issues including hypertension and cardiovascular diseases (CVDs). Several national and worldwide studies have estimated deaths from CVDs attributable to high sodium. But how to evaluate the impact of high sodium intake on diseases using regional routine monitoring and investigation data is necessary and important. Our study aimed to quantitatively evaluate the high sodium intake attributed to CVDs deaths based on the routine monitoring data from China National Nutrition and Health Survey (CNNHS) in Tianjin, China. The population attributable fractions (PAF) were calculated by comparing the observed systolic blood pressure (SBP) distribution with the theoretical minimum or counterfactual distribution by sex and age groups. The results showed that CVDs deaths due to elevated SBP were 22728 (95% uncertainty intervals: 22679‐23050), accounting for 62.8% of total CVDs deaths. According to sodium intake recommended by World Health Organization (WHO), PAF of CVDs deaths attributable to high sodium diet in our study was 14.6% of total CVDs deaths, accounting for 5228 (95% UI: 5005–5998) cases. The dietary sodium intake of residents is nearly three times than sodium intake recommended by WHO. If sodium intake was reduced to reference level, the potential avoidable CVD deaths attributable to the SBP‐raising effect were more than 5200 among adults 25 aged and over in Tianjin. This evaluation method can be extended to other cities.
Immediate effect of textured insoles on the balance in patients with diabetic neuropathy
Authors: Alaee Seyed Javad , Barati Kourosh , Hajiaghaei Behnam , Ghomian Banafshe , Moradi Sedigheh , Poorpirali Marziyeh 
Published: November 2022

AbstractAims/IntroductionNeuropathy is a common complication of diabetes that reduces balance by disrupting vision, and the sensory and vestibular systems. This is important in older adults who are more at risk of falling. Studies show that improving the sensory mechanisms through insoles can improve balance in people with balance disorders. As textured insoles have recently been considered for improving balance disorders, this study aimed to investigate the immediate effect of textured insoles on the balance of patients with diabetic neuropathy.Materials and MethodsA total of 17 patients with diabetic neuropathy participated in this quasi‐experimental study. The studied variables were the general balance index, posterior–anterior balance index and medial‐lateral balance index, which were measured in three conditions: (i) soft textured insoles; (ii) hard textured insoles; and (iii) without textured insoles. A Biodex balance device was used for this purpose.ResultsIn the general balance index, there was a significant difference between all the studied conditions. In the posterior–anterior balance index, there was a significant difference between without textured insole and hard textured insoles, and also soft and hard textured insoles. In the medial‐lateral balance index, there was a significant difference between the hard textured insoles and without textured insoles, and also soft and hard textured insoles (P < 0.05).ConclusionsWearing textured insoles can increase the balance in patients with diabetic neuropathy. This can be due to its effect on the sensory feedback of the soles, improving the proprioception and tactile sensors that are the main sources of balance.
Role of adenosine A2A receptors in the loss of consciousness induced by propofol anesthesia
Authors: Guo Meimei , Wang Jie , Yuan Yikang , Chen Lei , He Jingang , Wei Wei , Xu Fuqiang , Liu Qing , Peng Mian 
Published: November 2022

AbstractThe mechanism of propofol‐anesthesia‐induced loss of consciousness (LOC) remains largely unknown. We speculated that the adenosine A2A receptor serves as a vital molecular target in regulating LOC states under propofol anesthesia. c‐Fos staining helped observe the changes in the neuronal activity in the nucleus accumbens (NAc). Initially, the adenosine signals in the NAc were measured under propofol anesthesia using fiber photometry recordings. Then, behavior tests and electrophysiological recordings were used to verify the effect of systemic A2AR agonist or antagonist treatment on propofol anesthesia. Next, the microinjection technique was used to clarify the role of the NAc A2AR under propofol anesthesia. Fiber photometry recordings were applied to assess the effect of A2AR agonist or antagonist systemic treatment on adenosine signal alterations in the NAc during propofol anesthesia. Then, as the GABAergic neurons are the main neurons in the NAc, we further measured the neuronal activity of GABAergic neurons. In our study, propofol anesthesia enhanced the neuronal activity in the NAc, and the adenosine signals were increased in the NAc. SCH58261 reduced the LOC time and sedative depth, while CGS21680 increased those via intraperitoneal injection. Additionally, CGS21680 increased the changes in delta, theta, alpha, beta, and low‐gamma oscillations in the NAc. Moreover, microinjection of SCH58261 significantly shortened the LOC time, whereas microinjection of CGS21680 into the NAc significantly prolonged the LOC duration. The results illustrated that after A2AR agonist administration, the level of extracellular adenosine signals in the NAc was decreased and the neuronal activity of GABAergic neurons was enhanced, whereas after A2AR antagonist administration via intraperitoneal injection, the opposite occurred. This study reveals the vital role of the A2AR in propofol‐induced LOC and that the A2AR could affect the maintenance of propofol anesthesia.image
What kind of region reaps the benefits of a currency union?
Authors: Cerqua Augusto , Di Stefano Roberta , Pellegrini Guido 
Published: November 2022

AbstractWhat is the economic impact of joining a currency union? Is this impact heterogeneous across regions? And how does it change in case of a recession? We answer these questions by investigating the economic impact of joining the euro area for the latecomers, that is, the eastern European countries that adopted the euro after 2002. Differently from previous literature, we use NUTS‐2 regions as units of analysis. This novelty allows us to investigate the theoretical predictions of a currency union impact at a more appropriate geographical level. Using a recently developed counterfactual approach, we estimate the overall as well as the disaggregated impact of joining the euro area. We find that the adoption of the euro brought about a small positive effect, which was, however, dampened by the Great Recession. Individual regional estimates suggest heterogeneous returns with benefits accruing mostly to core regions.
Re‐engagement of Early Adolescents with Severe School Issues in School/Professional Project Reduces School‐Behavior‐Health Problems
Authors: Chau Kénora , Brard Emmanuelle , Riff Maria 
Published: November 2022

ABSTRACTBACKGROUNDIn France, 3.2 million middle‐school students have serious/persistent school difficulties and are re‐engaged in adapted‐general/vocational‐education class (AGVEC), created to early re‐engage them in school/professional projects. We assessed the AGVEC's benefits for school‐behavior‐health‐related difficulties (SBHDs).METHODSThis population‐based study compared 83 AGVEC students (mean age = 14.4 ± 1.1) with 1559 regular‐class students (mean age = 13.5 ± 1.3) from north‐eastern France. They completed a questionnaire collecting socioeconomic features and SBHDs. The data were analyzed using logistic regression models and Kaplan‐Meier estimates.RESULTSThe AGVEC students had similar academic performance but fewer school absences due to health problems, less sleep difficulty, fewer depressive symptoms, and more social support as compared with regular‐class students: sex‐age‐class‐level‐adjusted odds ratio (saclOR) 0.31‐0.56 (p < 0.05/0.001). The AGVEC students had fewer skipping school, better health status, less sleep difficulty, fewer depressive symptoms, fewer suicide ideation/attempt, and more social support as compared with regular‐class students with low academic performance: saclOR 0.22‐0.52 (most with p < 0.01). Socioeconomic features played modest roles. The benefits for depressive symptoms and suicide attempt increased with age since age 10.CONCLUSIONSRe‐engagement in the AGVEC is particularly effective in reducing SBHDs.