bluuebunny/crossref_metadata_2025_split huggingface dataset:
Multipurpose nanocomposite resist for free-standing transparent conductive thin films
Authors: Diaz Schneider Juan I , Chehade Pablo , Pérez-Morelo Diego , Granja Leticia P , Martínez Eduardo D 
Published: October 2022

Abstract
Nanocomposites formed by silver nanowires (AgNWs) embedded in a polymer matrix are a convenient way to deposit thin films with electrical conductance and high transparency on different substrates. Nanocomposite resists containing AgNWs in a poly(methyl methacrylate) solution can be effectively used to produce conductive coatings in a straightforward manner. Here, we show that by adding a sacrificial layer of polyvinylpyrrolidone on a glass substrate, prior to the nanocomposite resist, it is possible to obtain large-area free-standing films of about 450 nm with electrical conductance and high transparency. The films can be transferred to different surfaces and materials including non-flat substrates. The formation of conductive stacks by piling two layers was also demonstrated. The optical, electrical, and structural properties of these free-standing films were studied obtaining films with transmittance T(%) = 78% at 550 nm, sheet resistance Rs = (670 ± 40) Ω sq−1 and surface roughness Ra = (50 ± 10) nm. We studied the strain resistance behavior of films transferred to polyethylene terephthalate sheets under bending tests finding a sensitivity of (0.51 ± 0.01) Ω deg−1 and a gradual increase in the resistance during cycling. In addition, thin flexible supports can be added by covering the nanocomposite film with polydimethylsiloxane (PDMS) prior to its release, enhancing the mechanical robustness and improving the manipulation of the films.
Temperature dependence of the hyperfine parameters on Fe3O4(111) surfaces
Authors: Asakawa Kanta , Kawauchi Taizo , Fukutani Katsuyuki 
Published: October 2022

Abstract
The Verwey transition on Fe3O4(111) surface was investigated using nuclear resonant x-ray scattering (NRS). Measurements were conducted below (85 K) and above (297 and 500 K) the Verwey transition temperature. The internal magnetic field estimated from the NRS frequency spectra agreed with that of bulk Fe3O4 at all measured temperatures. A clear change in the intensity ratio of the two peaks in the frequency spectra was observed across the Verwey transition. The results indicate that despite the presence of the peculiar surface electronic states which makes the changes in the electronic properties across the Verwey transition temperature blurred, the hyperfine parameters of the (111) surface show a clear change across the Verwey transition temperature.
Asciminib (Scemblix): A third-line treatment option for chronic myeloid leukemia in chronic phase with or without T315I mutation
Authors: Monestime Shanada , Al Sagheer Tiba , Tadros Monica 
Published: October 2022

Abstract

Purpose
To review the pharmacology, efficacy, safety, dosing and administration, and place in therapy of asciminib, an oral tyrosine kinase inhibitor (TKI) used as a third-line treatment option for Philadelphia chromosome–positive chronic myeloid leukemia (CML) in chronic phase.

Summary
CML is a rare cancer caused by a chromosomal translocation that forms a fusion of the BCR and ABL1 genes on chromosomes 22 and 9. Until recently, patients for whom first-line treatment options failed were treated with TKIs that bind to the adenosine triphosphate–binding site on BCR-ABL1. However, because of similar mechanisms of action, there continues to be an unmet need in patients for whom at least 2 TKIs have failed or those with a T315I mutation unable to tolerate ponatinib. In October 2021, the Food and Drug Administration approved asciminib (Scemblix), the first TKI specifically targeting the ABL1 myristoyl pocket (STAMP) via allosteric binding, as a third-line option for patients with chronic-phase (CP)-CML. Asciminib received accelerated approval due to meeting its primary endpoint at week 24, demonstrating a major molecular response rate of 25.5% for patients on asciminib compared to 13.2% for those receiving bosutinib. In addition, patients on asciminib achieved a higher rate of complete cytogenetic response at 40.8% compared to a rate of 24.2% for bosutinib. Clinicians prescribing asciminib should monitor for increased levels of pancreatic enzymes, hypertension, cardiovascular toxicity including ischemic and thromboembolic conditions, and decreased numbers of neutrophils and platelets, as these may require treatment interruption, dose reduction, or treatment discontinuation.

Conclusion
Asciminib is a unique targeted TKI that provides clinicians with an additional third-line and beyond treatment option for adults with CP-CML regardless of mutation status as well as a second TKI treatment option for patients harboring a T315I mutation.
A Systematic Review and a Latin American Clinical Model for Teleneuropsychological Assessment
Authors: Serrano-Juárez Carlos Alberto , Reyes-Méndez Carolina , Prieto-Corona Belén , Seubert-Ravelo Ana Natalia , Moreno-Villagómez Julieta , Cabañas-Tinajero José-Ángel , Yáñez-Téllez Ma Guillermina , Quezada-Torres Rocío Alejandra , Téllez-Rodríguez Marybeth , Barrera-Rodríguez Bárbara , Soto-Jiménez Martha Paola , González-Gutiérrez Fátima Aideé , Castillo-Tejeda Elena 
Published: October 2022

AbstractObjectiveThe objective of this study is to propose a TeleNP model for remote assessment and offer practical recommendations for clinical practice with patients in Mexico and Latin America, based on a systematic literature review and clinical experience.MethodA systematic review of studies from 2011 to 2021 in English and Spanish used TeleNP, teleneuropsychology, telepsychology, online, assessment, teleneuropsicología, and evaluación for the search; the databases examined included PubMed, BiDi UNAM, ScienceDirect, Google Scholar, and Wiley One Library; the Oxford Centre for Evidence-Based Medicine system was used to grade the levels of evidence. The experience of the last two years of students and faculty in the Master’s and Doctoral Programs in Psychology, Clinical Neuropsychology Residency Program, was also used as a basis for this guide.ResultsWe propose a clinical model for TeleNP assessment in Mexico and Latin America based on the review of 31 articles and the practice of professors and students of clinical neuropsychology.ConclusionThe proposed model describes a procedure and adaptations for home-to-home clinical practice in the neuropsychological assessment of Mexican patients that could also be used in other Latin American countries. Its reliability remains to be assessed, but this model and the suggestions proposed could be used in future studies and clinical trials for Mexican and Latin American populations.
Immediate breast reconstruction uptake in older women with primary breast cancer: systematic review
Authors: Lee Rachel Xue Ning , Cardoso Maria Joao , Cheung Kwok Leung , Parks Ruth M 
Published: October 2022

Abstract

Background
Postmastectomy immediate breast reconstruction (PMIBR) may improve the quality of life of patients with breast cancer, of whom older women (aged 65 years or more) are a growing proportion. This study aimed to assess PMIBR in older women with regard to underlying impediments (if any).

Methods
MEDLINE, Embase, and PubMed were searched by two independent researchers up to June 2022. Eligible studies compared PMIBR rates between younger and older women with invasive primary breast cancer.

Results
A total of 10 studies (2012–2020) including 466 134 women were appraised, of whom two-thirds (313 298) were younger and one-third (152 836) older. Only 10.0 per cent of older women underwent PMIBR in contrast to 45.0 per cent of younger women. Two studies explored factors affecting uptake of PMIBR in older women; surgeon-associated (usual practice), patient-associated (socioeconomic status, ethnicity, and co-morbidities), and system-associated (insurance status and hospital location) factors were identified.

Conclusion
Uptake of PMIBR in older women is low with definable (and some correctable) barriers.
Tissue adhesive, adhesive tape, and sutures for skin closure of paediatric surgical wounds: prospective randomized clinical trial
Authors: Tandon Sarthak , Ensor Nicholas D , Pacilli Maurizio , Laird Ashleigh J , Bortagaray Juan I , Stunden Robert J , Nataraja Ramesh M 
Published: October 2022

Abstract

Background
Tissue adhesive, adhesive tape, and sutures are used to close surgical incisions. However, it is unclear which produces the best results in children, and whether combination wound closure is better than sutures alone.

Methods
In this parallel randomised controlled trial (ANZCTR: ACTRN12617000158369), children (aged 18 years or less) undergoing elective general surgical or urological procedures were randomized to skin closure with sutures alone, sutures and adhesive tape, or sutures and tissue adhesive. Participants were assessed 2 weeks, 6 weeks, and more than 6 months after operation. Outcomes included wound cosmesis (clinician- and parent-rated) assessed using four validated scales, parental satisfaction, and wound complication rates.

Results
295 patients (333 wounds) were recruited and 277 patients (314 wounds) were included in the analysis. Tissue adhesive wounds had poorer cosmesis at 6 weeks: median 10-point VAS score 7.7 with sutures alone, 7.5 with adhesive tape, and 7.0 with tissue adhesive (P = 0.014). Respective median scores on a 100-point VAS were 80.0, 77.2, and 73.8 (P = 0.010). This difference was not sustained at over 6 months. There was no difference in parent-rated wound cosmesis at 6 weeks (P = 0.690) and more than 6 months (P = 0.167): median score 9.0 with sutures alone, 10.0 with adhesive tape, and 10.0 with tissue adhesive at both stages. Parental satisfaction was similar at all points, with a median score of 5 (very satisfied) for all groups. There was one instance of wound dehiscence in the tissue adhesive group and no wound infections.

Conclusion
Short-term wound cosmesis was poorer with tissue adhesive although it is unclear whether this difference is sustained in the long-term. There were no differences between techniques for the study outcomes.

Registration number
ACTRN12617000158369 (ANZCTR) (https://anzctr.org.au/Trial/Registration/TrialReview.aspx?id=372177&isReview=true).
Antibiotic prophylaxis in breast cancer surgery (PAUS trial): randomised clinical double-blind parallel-group multicentre superiority trial
Authors: Stallard Sheila , Savioli Francesca , McConnachie Alex , Norrie John , Dudman Katie , Morrow Elizabeth S , Romics Laszlo 
Published: October 2022

Abstract

Background
Participants were patients with invasive breast cancer undergoing primary surgery. The aim was to test whether a single dose of amoxicillin–clavulanic acid would reduce wound infection at 30 days postoperatively, and to identify risk factors for infection.

Methods
Participants were randomised to either a single bolus of 1.2 g intravenous amoxicillin–clavulanic acid after the induction of anaesthesia (intervention) or no antibiotic (control). The primary outcome was the incidence of wound infection at 30 days postoperatively.

Results
There were 871 evaluable patients. Of these, 438 received prophylactic antibiotic and 433 served as controls. Seventy-one (16.2 per cent) patients in the intervention group developed a wound infection by 30 days, while there were 83 (19.2 per cent) infections in the control group. This was not statistically significant (odds ratio (OR) 0.82, 95 per cent c.i. 0.58 to 1.15; P = 0.250). The risk of infection increased for every 5 kg/m2 of BMI (OR 1.29, 95 per cent c.i. 1.10 to 1.52; P = 0.003). Patients who were preoperative carriers of Staphylococcus aureus had an increased risk of postoperative wound infection; however, there was no benefit of preoperative antibiotics for patients with either a high BMI or who were carriers of S. aureus.

Conclusion
There was no statistically significant or clinically meaningful reduction in wound infection at 30 days following breast cancer surgery in patients who received a single dose of amoxicillin–clavulanic acid preoperatively.

Registration number
N0399145605 (National Research Register).
Long-term outcomes of implant-based immediate breast reconstruction with and without radiotherapy: a population-based study
Authors: de Boniface Jana , Coudé Adam Hannah , Frisell Axel , Oikonomou Ira , Ansarei Dhirar , Ljung Konstantinidou Anna , Liu Yihang , Abo Alniaj Basel , Wallmon Paula , Halle Martin , Johansson Anna L V , Sackey Helena 
Published: October 2022

Abstract

Background
Radiotherapy (RT) is a risk factor for impaired outcomes after implant-based immediate breast reconstruction (IBR). Large studies including long-term follow-up are relatively scarce. The purpose of this analysis was to assess long-term effects of RT in implant-based IBR, distinguishing between implant removal because of postoperative complications versus patient preference.

Methods
This population-based cohort study included all patients with breast cancer who underwent implant-based IBR in Stockholm between 2005 and 2015. Data were collected through national registers and medical charts. The main endpoint was implant removal owing to postoperative complications (wound breakdown, infection, bleeding) or patient preference (dissatisfaction, pain, capsular contracture), with or without conversion to autologous reconstruction.

Results
Some 1749 implant-based IBRs in 1687 women were included. Median follow-up was 72 (range 1–198) months. Reconstructions were divided according to receipt of RT: No RT (n = 856, 48.9 per cent), adjuvant RT (n = 749, 42.8 per cent), and previous RT (n = 144, 8.2 per cent). Implant removal occurred after 266 reconstructions (15.2 per cent); 68 (7.9 per cent) in the no RT, 158 (21.1 per cent) in the adjuvant RT, and 40 (27.8 per cent) in the previous RT group. Implant removal was because of postoperative complications in 152 instances (57.1 per cent) and was most common in the first 3 years. This was especially observed in the previous RT group, where 15 of 23 implant removals occurred during the first 6 months. Implant removal owing to patient preference (114 of 266, 42.9 per cent) became more common with increasing follow-up.

Conclusion
Implant removal after implant-based IBR is significantly associated with RT. The reason for implant removal shifts over time from postoperative complications to patient preference.
Individual differences in brain aging: heterogeneity in cortico-hippocampal but not caudate atrophy rates
Authors: Nyberg Lars , Andersson Micael , Lundquist Anders , Baaré William F C , Bartrés-Faz David , Bertram Lars , Boraxbekk Carl-Johan , Brandmaier Andreas M , Demnitz Naiara , Drevon Christian A , Duezel Sandra , Ebmeier Klaus P , Ghisletta Paolo , Henson Richard , Jensen Daria E A , Kievit Rogier A , Knights Ethan , Kühn Simone , Lindenberger Ulman , Plachti Anna , Pudas Sara , Roe James M , Madsen Kathrine Skak , Solé-Padullés Cristina , Sommerer Yasmine , Suri Sana , Zsoldos Enikő , Fjell Anders M , Walhovd Kristine B 
Published: October 2022

Abstract
It is well documented that some brain regions, such as association cortices, caudate, and hippocampus, are particularly prone to age-related atrophy, but it has been hypothesized that there are individual differences in atrophy profiles. Here, we document heterogeneity in regional-atrophy patterns using latent-profile analysis of 1,482 longitudinal magnetic resonance imaging observations. The results supported a 2-group solution reflecting differences in atrophy rates in cortical regions and hippocampus along with comparable caudate atrophy. The higher-atrophy group had the most marked atrophy in hippocampus and also lower episodic memory, and their normal caudate atrophy rate was accompanied by larger baseline volumes. Our findings support and refine models of heterogeneity in brain aging and suggest distinct mechanisms of atrophy in striatal versus hippocampal-cortical systems.
Regional static diversification and relatedness between industries
Authors: Østergaard Christian Richter , Holm Jacob Rubæk 
Published: October 2022

Abstract
Relatedness has often been shown to have a central role in regional diversification. Knowledge flows between related industries are an important source of innovation, leading to industry growth and the establishment of new industries. Earlier studies have focused on dynamic diversification into new industries, but in this study, we emphasize static diversification, that is, changes in the balance between existing industries in a region. We use linked employer–employee data from Denmark and construct a range of measures at the level of regional industries. The role of relatedness in static diversification 2008–2013 is then analyzed based on industry characteristics in 2008. We find that relatedness plays a more important role in regions that are either spatially peripheral or economically non-peripheral, while relatedness has no relationship to static diversification on average. In addition to the empirical result, we contribute by comparing indices of relatedness, suggesting an alternative employment-weighted index, and conceptualizing relatedness as itself a disparity dimension of diversity. We finally ask how static and dynamic diversification affect disparity. We find that human capital intensity plays an important role in the link between diversification and the evolution of disparity.
Descriptive Analysis of Current Burn Care for Plain Communities in Ohio and Pennsylvania: A Qualitative Study of Strengths and Needs in a Hospital–Community Partnership
Authors: Snider Mira D H , Kelleher Jennifer , Brumbaugh Jamey T , Aballay Ariel , Duncan Christina L 
Published: October 2022

Abstract
Plain communities present with a higher risk of sustaining burn injuries. Yet, little is known about the hospital–community partnerships with Plain caretakers to facilitate culturally competent burn care. The current study provides a qualitative analysis of Plain caretakers’ perspectives on an existing hospital–community partnership for facilitating culturally sensitive burn care and their perspectives on the ongoing physical, structural, and behavioral health needs of this population. Twelve Plain community caregivers who serve on a burn wound treatment team or an oil therapy team within their community took part in a focus group interview. Caretakers identified as White, were majority male (83%), and resided in Plain communities. Retrospective thematic analysis was used to analyze the data. Five major themes (ie, informational needs, strengths of Plain community burn care, behavioral health concerns, behavioral health resources, and preferred teaching methods) evolved. Results revealed that Plain caregivers displayed an openness to learning about recommended burn care from the medical providers. Caretakers also cited their traditional (homeopathic) burn care procedures as perceived strengths, while simultaneously maintaining that their relationship with the hospital is a valuable part of life-saving burn care. Regarding their behavioral health needs, caretakers highlighted difficulties in helping their children cope with burn injuries and pain during rehabilitation and treatment. Other topics discussed included social support and cultural factors that impact the delivery of burn care to Plain communities from non-Plain providers. These results provide important considerations that other burn centers may consider when establishing similar partnerships to deliver of culturally competent medicine for Plain burn survivors.
Activation of cytokine responses by Candida africana
Authors: Rosati Diletta , Bruno Mariolina , van de Veerdonk Frank , ten Oever Jaap , Meis Jacques F , Netea Mihai G 
Published: October 2022

Abstract
Candida africana is a fungal pathogen that rarely causes invasive infections, but is mainly isolated from patients with vaginal infections. Vulvovaginal candidiasis is associated with dysregulated inflammatory responses of the host, however, the innate immune responses against C. africana are currently unknown. In this study, we explored the cytokine production of human peripheral blood mononuclear cells (PBMCs) in response to different C. africana isolates (intra-species diversity), and compared it with that induced by other yeasts belonging to the C. albicans species complex such as C. dubliniensis and C. albicans. Candida africana isolates induced both pro- and anti-inflammatory cytokines broadly similar to other Candida species. Candida africana-stimulated PBMCs tended to produce lower Interleukin (IL)-17 and IL-22 levels in comparison with C. albicans, whereas the induction of trained immunity was similar between C. africana and other Candida species. Overall, our results demonstrate that C. africana induces similar innate immune responses as the other Candida species. Therefore, its propensity to cause vulvovaginal infections is not due to an increased capacity to induce cytokine-related immune pathology. Nor is the infrequent occurrence of invasive infection by C. africana explained by a quantitatively different cytokine induction.
The stability of Prendergast magnetic fields
Authors: Kaufman Emma , Lecoanet Daniel , Anders Evan H , Brown Benjamin P , Vasil Geoffrey M , Oishi Jeffrey S , Burns Keaton J 
Published: October 2022

ABSTRACT
Convection in massive main-sequence stars generates large-scale magnetic fields in their cores that persists as they evolve up the red giant branch. The remnants of these fields may take the form of the Prendergast magnetic field, a combination of poloidal and toroidal field components that are expected to stabilize each other. Previous analytic and numerical calculations did not find any evidence for instability of the Prendergast field over short time-scales. In this paper, we present numerical simulations which show a long time-scale, linear instability of this magnetic field. We find the instability to be robust to changes in boundary conditions and it is not stabilized by strong stable stratification. The instability is a resistive instability, and the growth rate has a power-law dependence on the resistivity, in which the growth rate decreases as the resistivity decreases. We estimate the growth rate of the instability in stars by extrapolating this power law to stellar values of the resistivity. The instability is sufficiently rapid to destabilize the magnetic field on time-scales shorter than the stellar evolution time-scale, indicating that the Prendergast field is not a good model to use in studies of magnetic fields in stars.
Multi-heterointerfaces for selective and efficient urea production
Authors: Zhang Danyan , Xue Yurui , Zheng Xuchen , Zhang Chao , Li Yuliang 
Published: October 2022

ABSTRACTA major impediment to industrial urea synthesis is the lack of catalysts with high selectivity and activity, which inhibits the efficient industrial production of urea. Here, we report a new catalyst system suitable for the highly selective synthesis of industrial urea by in situ growth of graphdiyne on the surface of cobalt–nickel mixed oxides. Such a catalyst is a multi-heterojunction interfacial structure resulting in the obvious incomplete charge-transfer phenomenon between a graphdiyne and metal oxide interface and multiple intermolecular interactions. These intrinsic characteristics are the origin of the high performance of the catalyst. Studies on the mechanism reveal that the catalyst could effectively optimize the adsorption/desorption capacities of the intermediate and promote direct C–N coupling by significantly suppressing by-product reactions toward the formation of H2, CO, N2 and NH3. The catalyst can selectively synthesize urea directly from nitrite and carbon dioxide in water at room temperature and pressure, and exhibits a record-high Faradaic efficiency of 64.3%, nitrogen selectivity (Nurea-selectivity) of 86.0%, carbon selectivity (Curea-selectivity) of ∼100%, as well as urea yield rates of 913.2 μg h−1 mgcat−1 and remarkable long-term stability.