bluuebunny/crossref_metadata_2025_split huggingface dataset:
Aqueous Humor Cytokine Profiles of Pachychoroid Spectrum Diseases
Authors: Mao Jianbo , Chen Nuo , Zhang Caiyun , Zhang Shian , Xiang Ziyi , Shen Lijun 
Published: December 2022

Abstract
Objectives
To investigate cytokine profiles in the aqueous humor (AH) of patients with central serous chorioretinopathy (CSC), pachychoroid neovasculopathy (PNV), and polypoidal choroidal vasculopathy (PCV).
Methods
The prospective study included a total of 172 eyes. AH samples were collected from 65 eyes with CSC, 24 with PNV, and 43 with PCV before intravitreal anti-vascular endothelial growth factor (VEGF) injection and cataract surgery in 40 control eyes. Multiplex bead assay was used for analysis of cytokines, including VEGF, interleukin-6 (IL-6), IL-8, IL-10, interferon-inducible protein 10 (IP-10), macrophage chemoattractant protein 1 (MCP-1). Differences in cytokine levels between groups were assessed.
Results
No differences were noted in IL-6 (P = 0.122) and MCP-1 (P = 0.054) levels among the CSC, PNV, PCV, and controls. VEGF levels in CSC, PNV, and PCV were significantly higher than in controls (all P < 0.05). In CSC or PNV, no other inflammatory cytokines were upregulated except for VEGF compared to controls. In PCV, VEGF, IL-10, and IP-10 levels were significantly higher than those in controls. In addition, we compared the cytokines levels between two pigment epithelial detachment (PED) types in CSC patients. VEGF levels were significantly higher in eyes with flat irregular PED (FIPED) than in focal PED (P = 0.027).
Conclusions
In CSC and PNV, VEGF levels were elevated without the elevation of other inflammatory cytokines, indicating that inflammation was not the dominant factor on CSC and PNV diseases. PCV had significantly distinct cytokine profiles in the AH compared with controls. Elevated angiogenic and inflammatory cytokines, including VEGF, IL-10, and IP-10, may contribute to the pathogenesis of PCV. In addition, higher VEGF levels in CSC patients with FIPED verified that VEGF contributed more to the pathogenesis of FIPED compared with focal PED.
Effectiveness of the Sellick maneuver for painless gastroscopy in patients with esophageal hiatal hernia: a Randomized, self-control trial
Authors: Zhang Li , Shu Lei , Shi Zhaohong , Chen Zhijun 
Published: December 2022

Abstract
Background
Sellick maneuver is used for endotracheal intubation to prevent the occurrence of gastroesophageal reflux. Our study was to observe the effect of the Sellick maneuver on safety, esophageal closure status, gastric mucosal fold extension status, and positive detection rate of lesions in patients with esophageal hiatal hernia under painless gastroscopy.
Methods
Forty patients with esophageal hiatal hernia who underwent painless gastroscopy were screened for the Sellick maneuver, in which the operator applied pressure to the cervical cricoid cartilage during the examination. Compared with no-Sellick maneuver, we observed and recorded the status of esophageal closure at the pressing area, examination time, gastric mucosal fold extension score, positive rate of lesion detection, reflux of gastric juice or gastric contents, etc.
Results
After using the Sellick maneuver, the state of esophageal closure during gastroscopy was significantly better than the no-Sellick maneuver (P < 0.05), and the extension scores of the greater curvature folds of the gastric body, the lateral folds of the lesser curvature of the gastric body, and the mucosal folds of the fundus were significantly higher than that of the no-Sellick maneuver (P < 0.05). The number of gastric polyps examined with the Sellick maneuver was significantly more than no-Sellick maneuver(P < 0.01), and the number of gastric lesions examined (gastric ulcers, mucosal hyperplasia, etc.) was also significantly higher with the Sellick maneuver than no-Sellick maneuver (P < 0.01). The examination time was shorter with the Sellick maneuver than no-Sellick maneuver (p < 0.01). Reflux of gastric juice or gastric contents was superior to the no-Sellick maneuver (p < 0.01). The Sellick maneuver did not increase the degree of choking, as well as SPO2 variability and heart rate variability.
Conclusions
The Sellick maneuver effectively improved the extension of gastric mucosal folds during gastroscopy in patients with esophageal hiatal hernia, increased the positive detection rate of gastric lesions, and shortened the endoscopy time, while not increasing the incidence of cardia lacerations and didn’t affect the patient's voluntary breathing.
Trial registration:
The clinical trial was registered on (14/9/2022, ChiCTR2200063683)
WITHDRAWN: DOA estimation method for broadband sound sources based on multipath characteristics of shallow sea channels
Authors: Chen Hongyun , Li Xiaoman , Lu Hongyu , Mo Yaxiao 
Published: December 2022

Abstract
In order to improve the accuracy of direction of arrival (DOA) estimation and reduce the interference caused by multipath characteristics, this paper proposes an improved algorithm that can effectively suppress interference and improve the accuracy of direction estimation on the basis of the complex acoustic intensity target direction estimation method. The method first synthesizes the broadband pulse signal with the frequency domain acoustic pressure broadband, and after passing the synthesized signal through the channel, does the Fourier transform on it for time-frequency analysis, then does the Warping transform on the signal, separates and extracts the signal of each order of the simple positive wave to get the signal in the time domain condition, and then passes the obtained time-domain signal through the vector hydrophone separately to get the complex acoustic intensifier of the corresponding signal in the frequency domain, and finally passes the obtained Finally, the DOA estimation is carried out to obtain the average value of the complex acoustic intensity to obtain the azimuth angle.Compared with the traditional method, the proposed method can effectively suppress the interference caused by multipath characteristics and improve the accuracy of DOA estimation. Finally, the accuracy and effectiveness of the proposed method are verified by simulation and experimental data.
Landslide Susceptibility Mapping Using GIS and Bivariate Statistical Models in Chemoga Watershade, Ethiopia
Authors: Addis Abinet 
Published: December 2022

Abstract
In this study, landslide susceptibility mapping was carried out for Chemoga watershade upper Abay basin in Ethiopia using a bivariate statistical models of Frequency Ratio (FR) and Information Values (IV). The main objective of this study is to identified landslide susceptibility areas using GIS and Bivariate Statistical Models. Based on Google Earth imagery and filed survey, about 169 landslides were identified and classified randomly into training landslides datasets (70%) and the remaining (30%) of landslides datasets were used for validation purpose. The 10 landslides conditioning factors like slope, elevation, aspect, curvature, Topographic Wetness Index, Normalized Difference Vegetation Index, road, river, land use and rainfall were integrated with training landslides to determine the weights of each landslide conditioning factor and factor classes using both frequency ratio and information value models. The landslide susceptibility maps were produced by overlay the weights of all the landslide conditioning factors using raster calculator of the spatial analyst tool in ArcGIS 10.4. The final landslide susceptibility maps were reclassified as very low, low, moderate, high and very high susceptibility classes both FR and IV models.This susceptibility maps were validated using landslide area under the curve (AUC). The results of AUC accuracy models showed that the success rates of the FR and IV models were 0.870 and 0.901, while the prediction rates were 0.880 and 0.923 respectively. The outcome of this paper will help decision-makers for land use planning and landslide mitigation purpose in this study area.
Distribution systems reliability improvement using optimal phase balancing and economic analysis
Authors: Soltani Shirin. , Soltani Saeed. , rashidinejad masoud 
Published: December 2022

Abstract
Distribution systems are the most unbalanced part of the power network. This voltage unbalances can cause some major problems such as the abnormal performance of induction motors associated with their load increment, the network reliability decrease, increase in power losses, etc. So, phase balancing should be considered in distribution networks through the most effective rephasing strategy. In this paper, the optimal automatic rephasing strategy in order to improvement of distribution system reliability is investigated. On the other hand, the impacts of voltage unbalances on induction motors and their costs are optimized. Generally, this paper focuses on the system costs reduction through optimal automatic phase balancing especially in a smart environment. The proposed optimization model is solved by self-adaptive modified firefly algorithm (SAMFA). The performance of the SAMFA is compared with the ordinary firefly algorithm (FA), particle swarm algorithm (PSO) as well as genetic algorithm (GA). The proposed method is applied to the Kheibar feeder in Behbahan, Iran. Simulation studies and results analysis greatly demonstrate the significant economic benefits achieved from this research.
Upregulation of lncRNA SPINT1-AS1 by miR-200c/ZEB1 axis inhibits metastasis of breast cancer cells
Authors: Liu Chunshan , Du Kunpeng , Ai Meiling , Liu Wei , Liu Rongqiu , Zhang Fangmei , Dai Zili , Huang Xiuting , Xie Tao , Huang Xiaoting , Yuan Yawei , Wang Baiyao , Tian Yunhong 
Published: December 2022

Abstract
Background
Breast cancer is the most frequent and lethal malignancy among females worldwide. Metastasis crucially affects breast cancer-related deaths. Long noncoding RNAs (lncRNAs) are known to perform a crucial function in the regulation of biological processes in a variety of malignancies. The aim of this study was to evaluate the unidentified function played by the lncRNA SPINT1-AS1 and the relevant mechanism in the modulation of breast cancer-related metastasis.
Methods
Techniques such as immunohistochemistry (IHC) staining, western blotting, quantitative real-time polymerase chain reaction (qRT-PCR), and immunofluorescence (IF) were applied to evaluate RNA and protein expression profiles. In vitro Transwell and wound healing tests, as well as in vivo lung metastasis experiments, were conducted to validate the cell's ability to invade and migrate. To identify the transcription factors that are involved in lncRNA SPINT1-AS1 interactions, the Chromatin Immunoprecipitation(ChIP) and dual-luciferase reporter assays were carried out. Finally, the role of lncRNA SPINT1-AS1 was evaluated in patients with breast cancer.
Results
lncRNA SPINT1-AS1 and miR-200c showed low levels of expression in breast cancer cell lines. Furthermore, the overexpression of lncRNA SPINT1-AS1 or miR-200c in the cell lines decreased the tumor cell invasion. Mechanistically, miR-200c induced the overexpression of the lncRNA SPINT1-AS1 via the mechanism of causing zinc finger E-box-binding homeobox members 1 (ZEB1) to bind directly to the promoter DNA of the lncRNA SPINT1-AS1. The miR-200c mediated upregulation of the lncRNA SPINT1-AS1 suppressed breast cancer cell metastasis via the STAT3 signaling pathway.
Conclusion
lncRNA SPINT1-AS1, which was up-regulated by the miR-200c/ZEB1 axis, performs a crucial function in inhibiting metastasis of breast cancer cells via the Phosphorylation-signal transducer and activator of transcription 3(p-STAT3) pathway and can be a novel prognostic and treatment target for the disease.
A Retrospective Study of All-Ceramic Onlay Restorations
Authors: Domanic Kubra Yildiz , Aslan Yilmaz Umut , Ozkan Yasemin 
Published: December 2022

Abstract
Objectives: To evaluate the survival rate, failure, and clinical quality of all ceramic Onlay restorations retrospectively.
Methods: Restorations placed during the period September 2010 - April 2021 at Marmara University Dentistry Faculty Department of Prosthodontics were included. Patients with parafunctional habits were excluded from the study. In 62 patients, 115 onlay restorations were examined. The number of restoration failures and reasons for failure was recorded. The remaining onlay restorations were evaluated by CDA criteria (color match, anatomical form, marginal discoloration, marginal integrity, and surface texture) by two clinicians after 1–12 years. Patients also evaluated their restorations in five categories (color, surface, fonation, hygiene, and bite efficiency) on a scale of 1–10.
Results: A survival rate of 87.9 % was recorded. 14 (12.1%) of the 115 restorations had to be replaced. The main reasons for failure were 7 ceramic fractures (6.0%), 6 decementation (5.2%), four endodontic treatment needs (4.3%) and 2 extensive restoration needs (1.7%), 1 tooth fracture (0.8%). Conversely, patient satisfaction score was founded mostly over 8 and none of the patients rated under 3.
Conclusions: All ceramic Onlay restorations are an acceptable and predictable treatment alternative in general dental practice. In addition, the location of teeth in the dental arch and marginal integrities of teeth influenced restoration failures directly.
Clinical Significance: All ceramic Onlay restorations show a good clinical performance for up to 11 years.
FOXP3 promotes cell proliferation and metastases via the Wnt5a/CaMKII signaling pathway in choroidal melanoma
Authors: Yuan Yingying , Ma Qingyue , Gong Ruining , Wang Wenying , Yao Ningning , Zhao Han , Lei Ke , Fu Weiwei , Sui Aihua , Yu Xiaoling , Luo Wenjuan 
Published: December 2022

AbstractBackground:Choroidal melanoma (CM) accounts for 70% of uveal melanomas and is prone to metastasize and invade. Previous studies have reported that forkhead box protein 3 (FOXP3) is associated with carcinogenesis, however, the effect of FOXP3 on CM remains unclear. The purpose of the study is to explore the role of FOXP3 in the progression of CM and to elucidate its related mechanisms.Methods:FOXP3 protein expression was detected in CM clinical specimens and CM cells. We then established a cell line with stable FOXP3 knockout as well as a cell line that transiently overexpressed FOXP3, and their transfection efficiencies were detected by Western blotting (WB). The effects of FOXP3 on cell biological functions and epithelial-mesenchymal transition (EMT) in CM were verified via the CCK-8 assay, monoclonal formation assay, migration and invasion assays, WB and tumorigenesis assay in nude micein vivo. We also demontrated that FOXP3 promoted CM development through the Wnt5a/CaMKII signaling pathway.Results:The level of FOXP3 was found to be upregulated in CM clinical specimens and CM cells. The overexpression of FOXP3 promoted the proliferation, migration, invasion, and EMT process of CM cellsin vitro, while the knockdown of FOXP3 inhibited these cell functionsin vitroand tumor growthin vivo. In addition, FOXP3 was found promoting the progression of CM, including EMT, through the Wnt5a/CaMKII signaling pathway.Conclusion:This study demonstrated that FOXP3 promoted the development of choroidal melanoma through the Wnt5a/CaMKII signaling pathway as an oncogenic factor of CM, and thereby provides a novel potential target for the pathogenesis of CM.
NOMA Resource Allocation Method Based on Prioritized Dueling DQN -DDPG Network
Authors: Liu Yuan , Li Yue , Li Lin , He Mengli 
Published: December 2022

Abstract
In the mobile communication system, non-orthogonal multiple access (NOMA) technology is introduced to improve spectrum efficiency. Because the combination of users and the transmission power of each user are very important to the performance of NOMA system, the resource allocation technology of NOMA system has been widely studied. In recent years, scholars have introduced deep reinforcement learning network for user grouping and power allocation, which can effectively reduce the computational complexity and improve the system sum rate. However, the traditional algorithm based on DQN network still has the problems of slow convergence speed and low training stability, and the uniform sampling method in the sample playback process has the problem of low sampling efficiency. To address these problems, this paper proposes a priority-based user grouping and power allocation method of NOMA system optimized by Dueling DQN-DDPG, which can effectively improve the convergence speed and training stability. Firstly, in the user grouping stage, a user grouping network based on Dueling DQN is proposed. This network considers both the state value and the action value in the whole connection layer. The two values compete with each other, and then they are summed up and re-evaluated. The proposed network can effectively improve the stability of the traditional DQN network training process and speed up the training convergence. Secondly, considering the continuity of power value, DDPG network, which is suitable for dealing with continuous action space, is adopted in the power allocation stage, which can avoid the power quantization error. Finally, the priority sampling based on TD-error is combined with Dueling DQN network and DDPG network respectively, which can ensure random sampling and improve the replay probability of important samples. Simulation results show that the priority based Dueling DQN -DDPG algorithm proposed in this paper can greatly improve the convergence speed of sample training. At the same time, this scheme has the advantage of priority sampling, which can improve the learning speed and make the training process more stable. Compared with the traditional DQN algorithm, the convergence speed of the proposed algorithm is nearly doubled, and the training process is more stable, but the computational complexity is only increased by about 15%.
Phenotypes of Painful TMD in Discordant Monozygotic Twins According to a Cognitive-Behavioral-Emotional Model: A Case-Control Study
Authors: Magri Laís Valencise , Melchior Melissa de Oliveira , da-Silva Graziela Valle , Gherardi-Donato Edilaine Cristina da Silva , Leite-Panissi Christie Ramos Andrade 
Published: December 2022

Abstract
Objectives

this case-control study’s objective was to investigate variables based on a cognitive-behavioral-emotional model related to the development of painful temporomandibular disorders (TMD) in a sample of monozygotic twins discordant for the condition.

Materials and Methods

20 monozygotic twins (10 pairs discordant for painful TMD), aged between 18 and 55 years, were studied. The diagnosis of painful TMD was determined according to the Diagnostic Criteria for Temporomandibular Disorders - Brazilian Portuguese (DC/TMD). The cognitive-behavioral-emotional variables analyzed were sociodemographic profile, pain sensitivity (pain threshold to pressure, allodynia, and hyperalgesia), oral behaviors, pain vigilance and awareness, pain catastrophizing, central sensitization, stress, anxiety, depression, alexithymia, mindfulness facets, sleep quality, pain control, pain intensity and interference, trigeminal and extratrigeminal pain areas.

Results

According to the adjusted regression model, there was an increased chance of TMD with: an increasing left-sided masseter face pain sensitivity score (OR = 3.29;95%CI=(0.17–62.8),p = 0.428); an increasing total pain catastrophizing score (OR = 1.08; 95%CI=(0.64–1.8),p = 0.776); an increasing score of difficulty in externalizing feelings (OR = 1.61;95%CI=(0.13–2.9),p = 0.539); and a scoring of the distraction facet of the FFMQ scale (OR = 4.65;95%CI=(0.39–55.7),p = 0.225).

Conclusions

from the cognitive-behavioral-emotional model studied in this case-control study of monozygotic twins discordant for painful TMD, painful sensitivity in the face, catastrophizing pain, difficulty in externalizing feelings, and the distraction facet (mindfulness) are variables that increase the chance of developing painful TMD.
Clinical Relevance: This study with discordant monozygotic twins allows phenotype analyses, minimizing genetic and social influences. The results elucidate that cognitive-behavioral-emotional variables increase the chance of developing painful TMD, despite genetic influences.
Clade delineation and isolate-specific variability of Candida albicans exometabolome
Authors: ALABAN Leovigildo Rey , Bunescu Andrei , GHANEM Joséphine ABI , BEQUET Frédéric , KOSMALA Daria , BOUGNOUX Marie-Elisabeth , d'Enfert Christophe , THOMAS Vincent 
Published: December 2022

AbstractCandida albicansis a fungal pathobiont that relies on a vast molecular arsenal to navigate the host milieu and to confront the host immune defense. These molecular exchanges with the environment and the host are powered by a highly plastic metabolism, which is increasingly shown to vary between isolates. Unfortunately, metabolic variations are difficult to define inC. albicansas isolates (strains) are diverse and closely related. To overcome this constraint, we developed a high-throughput strategy to probe exometabolome variation inin vitrocultures of 95 clinical isolates from 12 major and five putative genetic clusters (clades). The workflow allows for the batch analysis of these isolates with robust replication (six or more replicates). Based on NMR (nuclear magnetic resonance) analysis of culture supernatants, we have shown delineation between clades, prominently clade 13 (corresponding to the so-calledC. africanaisolates) being metabolically distinct from the rest partly due to non-consumption of trehalose and weak utilization of choline. Further, using pairwise comparison, we could demonstrate that clades are delineated. We have also observed isolate-specific variation within clades, particularly in metabolites involved in central carbon metabolism. These results revealC. albicansas a consortium of isolates with divergent metabolic phenotypes.