bluuebunny/crossref_metadata_2025_split huggingface dataset:
Associations of state-level and county-level hate crimes with individual-level cardiovascular risk factors in a prospective cohort study of middle-aged Americans: the National Longitudinal Survey of Youths 1979
Authors: Gero Krisztina , Noubary Farzad , Kawachi Ichiro , Baum Christopher F , Wallace Robert B , Briesacher Becky A , Kim Daniel 
Published: January 2022

BackgroundThere have been long-standing debates about the potential health consequences of hate crimes over and above other types of crimes. Besides the direct consequences for victims, less is known about whether hate crimes have spillover effects onto the health of local residents.MethodsWe drew data on cardiovascular disease risk factors from middle-aged Americans in the National Longitudinal Survey of Youths 1979 and on hate crimes from the FBI’s Uniform Crime Reports. Employing multivariable logistic regression, we estimated the associations between changes in state/county-level all and group-specific hate crime rates from 2000 to 2006 and incident individual-level diabetes, hypertension, obesity and depressive symptoms from 2008 to 2016. All models controlled for individual-level sociodemographic factors and financial strain, county-level and state-level changes in the total crime rate, the percentage of non-Hispanic Black and Hispanic/Latino residents, and median household income, as well as state-level changes in the percentage of residents aged 65 years or older and the unemployment rate.Results1-SD increases in state-level all and race/ethnicity-based hate crime rates were associated with 20% (OR 1.20, 95% CI 1.05 to 1.35) and 15% higher odds (OR 1.15, 95% CI 1.01 to 1.31) of incident diabetes, respectively. At the county level, a 1-SD increase in the all hate crime rate was linked to 8% higher odds (OR 1.08, 95% CI 1.00 to 1.16) of obesity, while a 1-SD increase in the race/ethnicity-based hate crime rate was associated with 8% higher odds (OR 1.08, 95% CI 1.01 to 1.15) of obesity and 9% higher odds (OR 1.09, 95% CI 1.02 to 1.17) of hypertension. We found no significant associations for depressive symptoms, and no interactions between race/ethnicity-based hate crime rates and individual-level race/ethnicity.ConclusionLiving in areas with higher hate crime rates may confer higher odds of hypertension, diabetes and obesity.
Non-operative treatment for lumbar spinal stenosis with neurogenic claudication: an updated systematic review
Authors: Ammendolia Carlo , Hofkirchner Corey , Plener Joshua , Bussières André , Schneider Michael J , Young James J , Furlan Andrea D , Stuber Kent , Ahmed Aksa , Cancelliere Carol , Adeboyejo Aleisha , Ornelas Joseph 
Published: January 2022

ObjectivesNeurogenic claudication due to lumbar spinal stenosis (LSS) is a growing health problem in older adults. We updated our previous Cochrane review (2013) to determine the effectiveness of non-operative treatment of LSS with neurogenic claudication.DesignA systematic review.Data sourcesCENTRAL, MEDLINE, EMBASE, CINAHL and Index to Chiropractic Literature databases were searched and updated up to 22 July 2020.Eligibility criteriaWe only included randomised controlled trials published in English where at least one arm provided data on non-operative treatment and included participants diagnosed with neurogenic claudication with imaging confirmed LSS.Data extraction and synthesisTwo independent reviewers extracted data and assessed risk of bias using the Cochrane Risk of Bias Tool 1. Grading of Recommendations Assessment, Development and Evaluation was used for evidence synthesis.ResultsOf 15 200 citations screened, 156 were assessed and 23 new trials were identified. There is moderate-quality evidence from three trials that: Manual therapy and exercise provides superior and clinically important short-term improvement in symptoms and function compared with medical care or community-based group exercise; manual therapy, education and exercise delivered using a cognitive-behavioural approach demonstrates superior and clinically important improvements in walking distance in the immediate to long term compared with self-directed home exercises and glucocorticoid plus lidocaine injection is more effective than lidocaine alone in improving statistical, but not clinically important improvements in pain and function in the short term. The remaining 20 new trials demonstrated low-quality or very low-quality evidence for all comparisons and outcomes, like the findings of our original review.ConclusionsThere is moderate-quality evidence that a multimodal approach which includes manual therapy and exercise, with or without education, is an effective treatment and that epidural steroids are not effective for the management of LSS with neurogenic claudication. All other non-operative interventions provided insufficient quality evidence to make conclusions on their effectiveness.PROSPERO registration numberCRD42020191860.
Asthma, atopy and lung function in young adults after hospitalisation for bronchiolitis in infancy: impact of virus and sex
Authors: Sørensen Karen Galta , Øymar Knut , Dalen Ingvild , Halvorsen Thomas , Mikalsen Ingvild Bruun 
Published: January 2022

BackgroundHospitalisation for bronchiolitis is a risk factor for asthma and impaired lung function during childhood, but outcomes in young adults are poorly described. Our primary aim was to study the prevalence of asthma and atopy, and lung function at 17–20 years of age after bronchiolitis in infancy and, secondarily, the impact of viral aetiology (respiratory syncytial virus (RSV) vs non-RSV) and sex on these outcomes.MethodsThis Norwegian cohort study enrolled 225 young adults hospitalised for bronchiolitis in infancy during 1996–2001 and 167 matched control subjects. The follow-up included questionnaires for asthma and examinations of lung function and atopy. Outcomes were analysed by mixed effects regressions.ResultsCurrent asthma was more frequent in the postbronchiolitis group versus the control group: 25.1% (95% CI 19.0% to 31.2%) vs 13.1% (95% CI 7.9% to 18.2%), but not atopy: 44.3% (95% CI 37.1% to 51.5%) vs 48.2% (95% CI 40.5% to 55.8%), adjusted predicted proportions (95% CIs). Asthma prevalence did not differ between the RSV group and the non-RSV group: 24.0% (95% CI 16.1% to 32.0%) vs 23.8% (95% CI 12.8% to 34.7%) nor between sexes. Forced expiratory volume in 1 s (FEV1), the ratio FEV1/forced vital capacity (FVC), and forced expiratory flow between 25% and 75% of FVC, were lower in the postbronchiolitis group.ConclusionYoung adults hospitalised for bronchiolitis had higher prevalence of asthma, but not atopy, and a more obstructive lung function pattern than control subjects. The asthma prevalence was high after both RSV bronchiolitis and non-RSV bronchiolitis, and there was no difference between sexes. Bronchiolitis in infancy is associated with respiratory morbidity persisting into young adulthood.
Association between delays to patient admission from the emergency department and all-cause 30-day mortality
Authors: Jones Simon , Moulton Chris , Swift Simon , Molyneux Paul , Black Steve , Mason Neil , Oakley Richard , Mann Clifford 
Published: January 2022

BackgroundDelays to timely admission from emergency departments (EDs) are known to harm patients.ObjectiveTo assess and quantify the increased risk of death resulting from delays to inpatient admission from EDs, using Hospital Episode Statistics and Office of National Statistics data in England.MethodsA cross-sectional, retrospective observational study was carried out of patients admitted from every type 1 (major) ED in England between April 2016 and March 2018. The primary outcome was death from all causes within 30 days of admission. Observed mortality was compared with expected mortality, as calculated using a logistic regression model to adjust for sex, age, deprivation, comorbidities, hour of day, month, previous ED attendances/emergency admissions and crowding in the department at the time of the attendance.ResultsBetween April 2016 and March 2018, 26 738 514 people attended an ED, with 7 472 480 patients admitted relating to 5 249 891 individual patients, who constituted the study’s dataset. A total of 433 962 deaths occurred within 30 days. The overall crude 30-day mortality rate was 8.71% (95% CI 8.69% to 8.74%). A statistically significant linear increase in mortality was found from 5 hours after time of arrival at the ED up to 12 hours (when accurate data collection ceased) (p<0.001). The greatest change in the 30-day standardised mortality ratio was an 8% increase, occurring in the patient cohort that waited in the ED for more than 6 to 8 hours from the time of arrival.ConclusionsDelays to hospital inpatient admission for patients in excess of 5 hours from time of arrival at the ED are associated with an increase in all-cause 30-day mortality. Between 5 and 12 hours, delays cause a predictable dose–response effect. For every 82 admitted patients whose time to inpatient bed transfer is delayed beyond 6 to 8 hours from time of arrival at the ED, there is one extra death.
Outcomes of catecholamine and/or mechanical support in Takotsubo syndrome
Authors: Terasaki Satoshi , Kanaoka Koshiro , Nakai Michikazu , Sumita Yoko , Onoue Kenji , Soeda Tsunenari , Watanabe Makoto , Miyamoto Yoshihiro , Saito Yoshihiko 
Published: January 2022

ObjectiveThis study aimed to reveal the clinical characteristics of patients with severe Takotsubo syndrome (TTS) who needed catecholamine support (CS) or mechanical support (MS) and to identify factors associated with serious illness and in-hospital mortality.MethodsThis was a nationwide retrospective study that used claims data from the Japanese registry of all cardiac and vascular diseases and the diagnosis procedure combination registry, from April 2012 to March 2016. The patients with TTS were divided into severe TTS and mild TTS groups. The severe group was defined as patients who needed CS and/or MS.ResultsAmong 6169 patients with TTS, 1148 (18.6%) had severe TTS. No significant difference in age was found between the two groups; however, the number of female patients was significantly lower in the severe group than in the mild group. Among 130 patients who underwent MS, 22 and 108 patients required MS alone and both MS and CS, respectively. The 30-day mortality rate was significantly higher in the severe group than in the mild group (11.4% vs 2.6%, p<0.01) and increased with age. Of the patients with severe TTS, 65.6% died within 7 days. Multivariable analysis showed that male sex (OR 1.22, p=0.03), higher Charlson scores (OR 1.11, p<0.01), comorbid pneumonia (OR 1.68, p<0.01), comorbid sepsis (OR 6.02, p<0.01) and ambulance use (OR 2.01, p<0.01) were associated with severe TTS.ConclusionsThe rate of severe TTS was 18.6% among 6169 patients registered in the Japanese nationwide database, and the 30-day mortality was higher in patients with severe TTS than in those with mild TTS (11.4% vs 2.6%).
Health trends, inequalities and opportunities in South Africa’s provinces, 1990–2019: findings from the Global Burden of Disease 2019 Study
Authors: Achoki Tom , Sartorius Benn , Watkins David , Glenn Scott D , Kengne Andre Pascal , Oni Tolu , Wiysonge Charles Shey , Walker Alexandra , Adetokunboh Olatunji O , Babalola Tesleem Kayode , Bolarinwa Obasanjo Afolabi , Claassens Mareli M , Cowden Richard G , Day Candy T , Ezekannagha Oluchi , Ginindza Themba G , Iwu Chidozie C D , Iwu Chinwe Juliana , Karangwa Innocent , Katoto Patrick DMC , Kugbey Nuworza , Kuupiel Desmond , Mahasha Phetole Walter , Mashamba-Thompson Tivani Phosa , Mensah George A , Ndwandwe Duduzile Edith , Nnaji Chukwudi A , Ntsekhe Mpiko , Nyirenda Thomas Elliot , Odhiambo Julius Nyerere , Oppong Asante Kwaku , Parry Charles D H , Pillay Julian David , Schutte Aletta Elisabeth , Seedat Soraya , Sliwa Karen , Stein Dan J , Tanser Frank C , Useh Ushotanefe , Zar Heather J , Zühlke Liesl J , Mayosi Bongani M , Hay Simon I , Murray Christopher J L , Naghavi Mohsen 
Published: January 2022

BackgroundOver the last 30 years, South Africa has experienced four ‘colliding epidemics’ of HIV and tuberculosis, chronic illness and mental health, injury and violence, and maternal, neonatal, and child mortality, which have had substantial effects on health and well-being. Using data from the 2019 Global Burden of Diseases, Injuries and Risk Factors Study (GBD 2019), we evaluated national and provincial health trends and progress towards important Sustainable Development Goal targets from 1990 to 2019.MethodsWe analysed GBD 2019 estimates of mortality, non-fatal health loss, summary health measures and risk factor burden, comparing trends over 1990–2007 and 2007–2019. Additionally, we decomposed changes in life expectancy by cause of death and assessed healthcare system performance.ResultsAcross the nine provinces, inequalities in mortality and life expectancy increased over 1990–2007, largely due to differences in HIV/AIDS, then decreased over 2007–2019. Demographic change and increases in non-communicable diseases nearly doubled the number of years lived with disability between 1990 and 2019. From 1990 to 2019, risk factor burdens generally shifted from communicable and nutritional disease risks to non-communicable disease and injury risks; unsafe sex remained the top risk factor. Despite widespread improvements in healthcare system performance, the greatest gains were generally in economically advantaged provinces.ConclusionsReductions in HIV/AIDS and related conditions have led to improved health since 2007, though most provinces still lag in key areas. To achieve health targets, provincial governments should enhance health investments and exchange of knowledge, resources and best practices alongside populations that have been left behind, especially following the COVID-19 pandemic.
Reconsenting paediatric research participants for use of identifying data
Authors: Murdoch Blake , Jandura Allison , Caulfield Timothy 
Published: January 2022

When a minor research participant reaches the age of majority or the level of maturity necessary to be granted legal decision-making capacity, reconsent can be required for ongoing participation in research or use of health information and banked biological materials. Despite potential logistical concerns with implementation and ethical questions about the trade-offs between maximising respect for participant agency and facilitating research that may generate benefits, reconsent is the approach most consistent with both law and research ethics.Canadian common law consent requirements are expansive and likely compel reconsent on obtaining capacity. Common law doctrine recognises that children are entitled to decision-making authority that reflects their evolving intelligence and understanding. Health consent legislation varies by province but generally either compels reconsent on obtaining capacity or delegates the ability to determine reconsent to research ethics boards. These boards largely rely on the Canada’s national ethics policy, the Tri-Council Policy Statement, which states that, with few exceptions, reconsent for continued participation is required when minors gain capacity that would allow them to consent to the research in which they participate. A strict interpretation of this policy could require researchers to perform frequent capacity assessments, potentially presenting feasibility concerns. In addition, Canadian policy and law are generally consistent with the core principles of key international ethical standards from the United Nations and elsewhere.In sum, reconsent of paediatric participants upon obtaining capacity should be explicit and informed in Canada, and should not be presumed from continued participation alone.
Rescue technique for trapped bone needle in cement cast
Authors: Dimancea Alexandru , Premat Kevin , Shotar Eimad , Cormier Evelyne , Chiaroni Pierre-Marie , Mahtout Jugurtha , Clarençon Frédéric 
Published: January 2022

Avascular necrosis, or Kummel disease, is a potential complication of vertebral compression fractures. It is believed to arise as a result of a failed fracture healing process,1 2 leading to the formation of an air or fluid filled cavity within the vertebral body.3 Percutaneous vertebroplasty seems to provide both pain relief and increased spinal stability in avascular necrosis.4 In this technical video, we present the case of an osteoporotic patient with a complicated vertebroplasty, caused by trapping of the bone needle inside the intravertebral cement cast. Two methods were used sequentially, leading to retrieval of the bone needle. We identified several technical aspects, such as injection speed, quasi-filling of the vertebral cavity, and frequent rotation of the bone needle as essential for the success of the procedural. We suggest that improving these parameters may prevent intravertebral bone needle trapping in patients with avascular necrosis.Video 1
Characteristics of circulatory failure after out-of-hospital cardiac arrest: a prospective cohort study
Authors: Langeland Halvor , Bergum Daniel , Løberg Magnus , Bjørnstad Knut , Skaug Thomas R , Nordseth Trond , Klepstad Pål , Skjærvold Nils Kristian 
Published: January 2022

BackgroundCirculatory failure after out-of-hospital cardiac arrest (OHCA) as part of the postcardiac arrest syndrome (PCAS) is believed to be caused by an initial myocardial depression that later subsides into a superimposed vasodilatation. However, the relative contribution of myocardial dysfunction and systemic inflammation has not been established. Our objective was to describe the macrocirculatory and microcirculatory failure in PCAS in more detail.MethodsWe included 42 comatose patients after OHCA where circulatory variables were invasively monitored from admission until day 5. We measured the development in cardiac power output (CPO), stroke work (SW), aortic elastance, microcirculatory metabolism, inflammatory and cardiac biomarkers and need for vasoactive medications. We used survival analysis and Cox regression to assess time to norepinephrine discontinuation and negative fluid balance, stratified by inflammatory and cardiac biomarkers.ResultsCPO, SW and oxygen delivery increased during the first 48 hours. Although the estimated afterload fell, the blood pressure was kept above 65 mmHg with a diminishing need for norepinephrine, indicating a gradually re-established macrocirculatory homoeostasis. Time to norepinephrine discontinuation was longer for patients with higher pro-brain natriuretic peptide concentration (HR 0.45, 95% CI 0.21 to 0.96), while inflammatory biomarkers and other cardiac biomarkers did not predict the duration of vasoactive pressure support. Markers of microcirculatory distress, such as lactate and venous-to-arterial carbon dioxide difference, were normalised within 24 hours.ConclusionThe circulatory failure was initially characterised by reduced CPO and SW, however, microcirculatory and macrocirculatory homoeostasis was restored within 48 hours. We found that biomarkers indicating acute heart failure, and not inflammation, predicted longer circulatory support with norepinephrine. Taken together, this indicates an early and resolving, rather than a late and emerging vasodilatation.Trial registrationNCT02648061.
Effects of osteoporosis medications on bone fracture in patients with chronic kidney disease
Authors: Kao Chih-Chin , Wu Pei-Chen , Chuang Ming-Tsang , Yeh Shu-Ching , Lin Yen-Chung , Chen Hsi-Hsien , Fang Te-Chao , Chang Wei-Chiao , Wu Mai-Szu , Chang Tzu-Hao 
Published: January 2022

Abstract

Purpose of the study
The risk of bone fracture is high in patients with chronic kidney disease (CKD), and aggressive treatment to reduce fragility fracture risk is the major strategy. However, the outcomes of osteoporosis medications in patients with CKD remain unclear.

Study design
Patients with stage 3–5 CKD during 2011–2019 were enrolled. Patients were divided into two groups based on receiving osteoporosis medications (bisphosphonates, raloxifene, teriparatide or denosumab) or not. Two groups were matched at a 1:1 ratio by using propensity scores. The outcomes of interest were bone fractures, cardiovascular (CV) events and all-cause mortality. Cox proportional hazard regression models were applied to identify the risk factors. Additional stratified analyses by cumulative dose, treatment length and menopause condition were performed.

Results and conclusions
67 650 patients were included. After propensity score matching, 1654 patients were included in the study and control group, respectively. The mean age was 70.2±12.4 years, and 32.0% of patients were men. After a mean follow-up of 3.9 years, the incidence rates of bone fracture, CV events and all-cause mortality were 2.0, 1.7 and 6.5 per 1000 person-months, respectively. Multivariate analysis results showed that osteoporosis medications reduced the risk of CV events (HR, 0.35; 95% CI, 0.18 to 0.71; p = 0.004), but did not alleviate the risks of bone fracture (HR, 1.48; 95% CI, 0.73 to 2.98; p = 0.28) and all-cause mortality (HR, 0.93; 95% CI, 0.67 to 1.28; p = 0.65). Stratified analysis showed that bisphosphonates users have most benefits in the reduction of CV events (HR, 0.26; 95% CI, 0.11 to 0.64; p = 0.003). In conclusion, osteoporosis medications did not reduce the risk of bone fractures, or mortality, but improved CV outcomes in patients with CKD.
In vitro propagation ofVaccinium floribundumKunth from seeds: promissory technology for mortiño accelerated production
Authors: Meneses L.S. , Morillo L.E. , Vásquez-Castillo W. 
Published: January 2022

The Andean mortiño (Vaccinium floribundum Kunth) grows wild in the northern paramos of South América. The berries present potential opportunities for agribusiness, but an efficient technology for the production of plants and berries is required. On the other hand, the development of plant production methods from mortiño seeds will allow the plants’ accessibility and its potential use in breeding programs. The objective of this study was to develop an efficient in vitro protocol for accelerated production using seeds. We carried out the research in four phases: seed germination, plant multiplication, rooting, and acclimatization in the greenhouse. For in vitro seed germination, we studied the effect of two culture media [woody plant medium (WPM) and Murashige and Skoog medium (MS], two photoperiods (16 and 24 hours of light), and two temperatures (18 and 28 °C). The best treatment was found to be WPM + 24 h light + 18 °C. In the micropropagation of seedlings, the effect of two concentrations of three cytokinines [(trans-zeatin riboside (TZR), zeatin (ZEA), and 2-isopentenyl adenine (2iP)], and two photoperiods (16 and 0 h light) was evaluated, whereby the concentration of 0.5 mg L−1of TZR was the best treatment. For rooting, two doses of three auxins [indole-3-butyric acid (IBA), 1-naphthaleneacetic acid (NAA), and indole-3-acetic acid (IAA)] were evaluated, resulting in the 2 mg·L−1concentration of IBA giving the best root induction. Finally, the in vitro rooted plants were acclimatized in a greenhouse. We found that peat was the best substrate. These results show that the technology developed here is useful for in vitro production of V. floribundum using seeds.
Role of gravitational decoupling on isotropization and complexity of self-gravitating system under complete geometric deformation approach
Authors: Maurya S. K. , Nag Riju 
Published: January 2022

AbstractIn the present paper, we discuss the role of gravitational decoupling to isotropize the anisotropic solution of Einstein’s field equations in the context of the complete geometric deformation (CGD) approach and its influence on the complexity factor introduced by Herrera (Phys Rev D 97:044010, 2018) in the static self-gravitating system. Moreover, we proposed a simple and effective technique as well to generate new solutions for self-gravitating objects via CGD approach by using two systems with the same complexity factor and vanishing complexity factor proposed by Casadio et al. (Eur Phys J C 79:826, 2019). The effect of decoupling constant and the compactness on the complexity factor have also been analyzed for the obtained solutions.