bluuebunny/crossref_metadata_2025_split huggingface dataset:
KÜRESEL DEĞER ZİNCİRLERİ BAĞLAMINDA İKTİSADİ BAĞIMSIZLIK HEDEFLERİNİN YENİDEN TANIMLANMASI
Authors: YÜCER Ayçıl 
Published: September 2022

Küresel Değer Zincirlerinin (KDZ) ticarete olan etkisi Dünya Ticaret Örgütü gibi uluslararası organizasyonlar ve konunun uzmanı birçok ekonomist tarafından bir “paradigma kayması” olarak nitelenmektedir. Yaşanan köklü değişim dış ticaret politikası hedeflerinin yeniden belirlenmesi ihtiyacını doğurmanın yanı sıra, geleneksel analiz yöntemlerinin de hem ampirik hem de teorik anlamda sorgulanmasına neden olmaktadır. Bu çalışmanın amacı, politika hedeflerinin belirlenmesinde KDZ’lerin yapısal özelliklerinin ve farklı ülke rollerinin önemini vurgulayarak, KDZ göstergelerinin doğru yorumlanmasına katkı sağlayacak bütüncül ve genel bir çerçeve sunmaktır.
Çalışmada KDZ altında gelişen ithalat bağımlılığının, dışa bağımlılığın temel göstergesi olmaktan çıktığı ve ithalatın ihracat içerisindeki payının azaltılmasına yönelik politikaların ülkelerin bağımsızlık hedefleriyle ters düşebileceği görülmüştür. Bu bağlamda ülkelerin iktisadi bağımsızlıkları zincirdeki pazarlık güçleri ve katma değer paylarını önceleyen bir yaklaşım çerçevesinde yeniden tanımlanmıştır. Son olarak, KDZ literatürü bağlamında kullanımı öne çıkan ve KDZ’lerin yapısal özelliklerini ve ülkelerin katılımlarını ölçmekte kullanılan birçok yeni göstergenin hesaplanma yöntemi ve katma değer ile ilişkisi de sunulmuştur. Ancak literatürdeki Türkiye odaklı diğer çalışmalardan farklı olarak, bu araştırma makalesinde ampirik bir analiz yürütülmemiştir.
An assessment of knowledge, attitudes and perceptions of great Zimbabwe university students towards COVID-19 vaccination-Zimbabwe
Authors: Mabika Nyasha 
Published: September 2022

<p><strong>Background</strong>: Vaccination is one of the most effective measures to prevent the spread of COVID-19. However, the knowledge, attitudes and perceptions of the intended population towards vaccination is important for successful implementation of the exercise. The objective of the study was to assess the knowledge, attitudes and perceptions of Great Zimbabwe University students towards COVID-19 vaccination.</p><p><strong>Methods:</strong> An online survey was conducted from 01 November to 17 December 2021 by requesting students to complete a questionnaire which was set up using Google forms. The generated link was shared on student portals.</p><p><strong>Results:</strong> The most common source of information on COVID-19 vaccination was social media. The majority of the respondents demonstrated their knowledge of how COVID-19 is transmitted and indicated that they would take the COVID-19 vaccine if it is available. Most respondents indicated that they would encourage family/ friends/relatives to get vaccinated. About 87% were worried about being infected with COVID-19 and 26.4% were hesitant to get COVID-19 vaccine. Over 68 % perceived that vaccination would stop the spread of COVID-19. About 81% feared that there was a high risk of getting infected with COVID-19 at the university.</p><p><strong>Conclusions:</strong> The majority of university students intended to get the COVID-19 vaccine; The sources of information cited by the students should be prioritized in disseminating COVID 19 vaccination information. These findings can help the Ministry of Health plan for future efforts to increase vaccine uptake that may eventually lead to herd immunity against COVID-19.</p>
Can Video Head Impulse Test Determine the Early Effect of Cochlear Implantation on the Semicircular Canals Function?
Authors: Kardooni Maryam , Ahmadi Roghayeh , Saki Malehi Amal , Kiani Ayeh , Saki Sara 
Published: September 2022

Background and Aim: Although cochlear implantation (CI) is a safe surgical procedure for severe to profound sensorineural hearing loss (SNHL) but, due to the embryological and anatomical connection between the vestibular and cochlear structures, vestibular dysfunction may occur after CI. Video head impulse test (vHIT) is a reliable test for assessing the function of semicircular canals (SCCs). This study aimed to determine the early effect of CI on SCCs function, by comparing pre- and post-operative vHIT results.
Methods: In this cross-sectional study, participants were 22 adults with SNHL scheduled for unilateral CI in the right ear and 22 age-matched healthy subjects as a control group. The vHIT was conducted before and two weeks after CI.
Results: The mean vHIT gains in the SNHL group were significantly lower than in controls, with a large effect size. Furthermore, the mean vHIT gains in the right lateral SCCs (p<0.001) and right anterior SCCs (p=0.003) were significantly reduced after CI, compared to the gain values before CI, with a large pooled effect size. However, these differences were not statistically significant for the right posterior SCCs. The comparison of vHIT gains in the non- implanted ear showed no statistically significant difference between pre- and post-operative phases.
Conclusion: The vHIT is a useful clinical method to detect the early effects of CI on the function of SCCs. These effects are more obvious in the lateral and superior SCCs in the implanted ear.
Keywords: Cochlear implantation; semicircular canals; video head impulse test
Acceptable Noise Level in Children with Unilateral Cochlear Implant and Bimodal Hearing
Authors: Ashjaei Samin , Jalilvand Hamid , Hadipour Hadi , Sadeghi Reza 
Published: September 2022

Background and Aim: Difficulty in perception of speech in noise is one of the main complaints of hearing-impaired people. Due to profound hearing loss in cochlear implant (CI) users, they need higher signal-to-noise ratio for a better perception. Bimodal fitting is a preferred way for CI users because it prevents auditory nerve degeneration, is a complement of frequency range at the opposite ear, an is less invasive to provide binaural hearing. Acceptable noise level (ANL), as a reliable test to assess noise tolerance, has not yet been used in comparing children with bimodal hearing and CI. This study aimed to determine whether bimodal fitting can help CI children tolerate more noise.
Methods: This descriptive-analytical study was conducted on 13 children with unilateral CI and bimodal hearing. Audiometry test was performed at aided and non-aided conditions. Then, their noise tolerance was assessed by the Persian version of ANL test.
Results: Bimodal hearing resulted in statistically significant increase in ANL. The mean of ANL at unilateral CI and bimodal hearing conditions were 6.15±2.90 and 4.77±1.70, respectively.
Conclusion: Bimodal fitting lead to more noise tolerance in unilateral CI children due to the combination of binaural summation and binaural release from masking.
Keywords: Acceptable noise level; cochlear implant; hearing aid; bimodal hearing; profound hearing loss; binaural hearing
JOINT COMPREHENSIVE PLAN OF ACTION (JCPOA): PROSPECTS AND CHALLENGES FOR THE GLOBAL SECURITY
Authors: Babar Summar Iqbal , Mirza Muhammad Nadeem , Qaisrani Irfan Hasnain 
Published: September 2022

Purpose of the study: The Iranian Nuclear ambition is an issue that tends to disturb the strategic balance and therefore the peace in the world’s most important geopolitical and geostrategic region; the Middle East.This study intends to explore the Joint Comprehensive Plan of Action (JCPOA), the agreement signed to reign the Iranian nuclear ambitions.
Methodology: This is exploratory qualitative research. It utilises the embedded case study method in which the said phenomenon is explored at different levels of analysis.
Main Findings: Though there existed different types of perceptions vis-à-vis JCPOA, commonly known as the Iranian nuclear deal, yet the withdrawal of the US from it under the Trump administration gave Iran a rationale to further pursue its nuclear ambitions. So, the US withdrawal from the deal has enhanced the threat perceptions for global and regional security.
Applications of this study: The study targets the students, scholars, and policy practitioners of Middle Eastern studies.
Novelty/Originality of this study: The novelty is the use ofan embedded case study method to explore the impact of the JCPOA and US withdrawal from it, at different levels of analysis.
Sustainable development of clothing brands based on LPP S.A. Analysis
Authors: Gradowska Julia , Wołosowicz Natalia 
Published: September 2022

Purpose of the study: The subject of consideration is the actual actions of clothing brands in pro-environmental areas. The main purpose of the article is to describe the sustainability and pro-environmental behavior of companies selling private label clothing.
Methodology: This article was prepared with the use of analyses of LPP S.A. reports, rankings of environmentally conscious brands and other articles.
Findings of the study: Sustainable development is influencing the increased use of organic products. By adopting pro-environmental solutions, brands are gaining the support of an increasingly environmentally conscious society, which is pushing companies to use eco-friendly solutions in production, transport and low-impact cultivation. Unfortunately, companies often use the growing trend of sustainability to maximize profits, which leads to creating a phenomenon such as greenwashing.
Application of the study: This article presents the behavior of LPP S.A. in the areas of ecological, sustainable development. Using an analysis of the company’s reports and rankings, it can be seen that companies are paying more and more attention to pro-ecological behavior.
Originality/Novelty of the study: The concept of sustainability is overlooked in terms of clothing brands that have high environmental impact.
Responses of ground-dwelling arthropods to long-term prescribed fire regimes in a savanna protected area.
Authors: Mukwevho Ludzula , Ndlovu Mduduzi , Chikowore Gerald , Dalu Tatenda , Mutamiswa Reyard , Chidawanyika Frank 
Published: September 2022

Abstract

Background
Sound management of protected areas is crucial for biodiversity conservation. In savanna systems, fire is common, yet little is known on the direct and long-term effects of prescribed burns on arthropod abundance, richness, and diversity. Standardised pitfall traps and active searches were used to compare variation in abundance, richness and diversity of arthropods at various experimental burn plots in the Kruger National Park, a protected area in a savanna setting.
Results
Hymenopterans: Formicidae were the most abundant (76.4%), whilst Coleopterans, Araneae and Orthopterans constituted 18.6, 3 and 1% of the total arthropods collected respectively. Coleopterans were the most diverse group (30.2%) compared to Hymenopterans: Formicidae (24.6), Araneae (24.6) and Orthopterans (4%). Abundance, species richness and diversity of multi-taxa significantly differed between the treatment plots. Abundance and diversity of Formicidae were significantly lower, hence, species richness was significantly higher in annually burnt plots compared to the unburnt control plots. Although the highest number of arthropods was recorded in unburnt plots, species richness and diversity were lowest in these plots compared to those burnt annually and triennially.
Conclusions
We conclude that late summer burns do not have major ecological impact on arthropods, and it was demonstrated by the abundance and diversity of species recorded at the annually burnt plots. Thus, annual late summer burns can be used as a conservation tool for arthropod inhabiting the protected savanna of Kruger National Park.
Study of dam-break flow over a vegetated channel with and without a drop
Authors: Khoshkonesh Alireza , Sadeghi Seyed Hossein , Gohari Saeed , Karimpour Somaye , Oodi Shahin , Francesco Silvia Di 
Published: September 2022

Abstract
The development of catastrophic floods triggered by a dam failure is influenced by the river's bed nonuniformity, infrastructure, and vegetation in the main channel or floodplain. This study examined the effects of the presence of a drop and its direction in a vegetated channel on flow characteristics during dam failure. A CFD package was used for all dam break flow simulations. Using experimental data from the literature, a sensitivity analysis of the fluid cell size and turbulence models were performed. Then, the model was used to predict the flow characteristics during a dam break over the vegetated channel with positive, negative, and no drops. The results showed that the model reproduced with high accuracy the evolution of the flow during a dam break in the presence of an obstacle and transitions, as well as variations in flow velocity. The presence of a drop, its height and direction, and vegetation significantly changed the reservoir discharge, hydrograph in the downstream channel, flow velocity values, location of the inflection points, density, and eddy evolution.
Effect of different custom-made mouthguard palatal extensions on the stress-state of dentoalveolar: a 3D-FEA
Authors: Sun Zhe , Zhang Jiayun , Sun Ruitong , Zhang Meng , Zhong Qingqiu , Huang Minghao , Yan Xu , Li Jian 
Published: September 2022

Abstract
Objectives
The present study aimed to simulate the influence of the palatal extension of a custom-made mouthguard (MG) on protecting dentoalveolar structures and to provide a theoretical basis for designing a comfortable MG.
Materials and Methods
Based on the finite element analysis (3D-FEA) method, five groups of maxillary dentoalveolar models of wearing MG were established —no MG on the palatal side (NP), on the palatal gingival margin (G0), 2 mm from the palatal gingival margin (G2), 4 mm from the palatal gingival margin (G4), 6mm from the palatal gingival margin (G6) and 8mm from the palatal gingival margin (G8). A cuboid was created to simulate the ground, a gradually increasing force was applied from 0N to 500N on the vertical ground and the distribution and peak values conditions of the Critical modified von-Mises stress, maximum principal stress and displacement of dentoalveolar models were calculated.
Results
The stress distribution range, stress and deformation peak value of dentoalveolar models increased as the impact strength increased, at 500N, but the position of the MG palatal edge had little effect on the stress distribution, stress and deformation peak value of the dentoalveolar models.
Conclusions
The different extension ranges of the MG palatal edge have little effect on the protective ability of the MG on maxillary teeth and maxilla. An appropriate palatal extension of MG is the key to improving their wearing comfort, which may help dentists to design a suitable MG and increase its usage.
Clinical Relevance
Optimized MGs' palatal design to provide a comfortable MG for those involved in sports and increase the usage of the MGs.
Fluoride concentration in saliva after toothbrushing with power or manual toothbrush and Sodium Fluoride-containing toothpaste, a clinical crossover study
Authors: Bottenberg Peter , De Bruyne Anneveere , Verhelle Heleen , Jacquet Wolfgang 
Published: September 2022

Abstract
Background

Power toothbrushes gain increasing acceptance for oral hygiene procedures. However, the brush head is generally smaller than that of a manual brush thus accommodating less toothpaste. This might influence salivary fluoride concentrations.

Methods

In a group of 20 adult volunteers in a 2-legged crossover study. They were instructed to use their habitual quantity of toothpaste (containing 1450ppm as NaF) ad libitum on a manual or power toothbrush. Salivary samples were taken at baseline, after 2 minutes brushing, after 5 minutes and then stepwise up to 60 minutes after brushing. Salivary samples were electrochemically analyzed for fluoride (ISE) for TF (total fluoride, whole sample after acid digestion) and IF (ionizable fluoride after centrifugation but without digestion), Area under the curve (AUC) and curve parameters after regression were calculated and compared using nonparametric statistical methods.

Results

Toothpaste quantity was significantly (p < 0.05) higher with manual toothbrushes (manual ranging from 0.3-2.1g, electric from 0.2-1.2g). Volunteers placing low amounts of toothpaste on a manual brush also did so on the power brush (Spearman-rank correlation coefficient 0.503, p = 0.024). However, this difference in quantity was not reflected in AUC in saliva (p > 0.05). A small but significant difference was found between TF and IF for AUC, reflecting some interaction between saliva compounds and fluoride, independent of toothbrush type.

Conclusions

Interindividual variability is more important in fluoride availability in saliva than differences in toothpaste quantity between power and manual toothbrushing.
Trial registration: Belgian health authorities n° B670201836852
Trial registration: Belgian health authorities n° B670201836852
Fangchinoline derivatives inhibits PI3K signaling in vivo and in vitro in non-small cell lung cancer
Authors: Chen Jia-shu , Guo Xu , Wang Mu-xuan , Gao Xiu-zheng , Han Jin-long , Sun Jin-yue , Li Ning-yang , Simal-Gandara Jesus , Liu Chao 
Published: September 2022

Abstract
Background
Cancer is a primary public health problem worldwide today. Tetrandrine (Tet) and fangchinoline (Fan) are extracted from the traditional Chinese medicine Stephania tetrandra S., which are two types of bis-benzyl isoquinoline alkaloids with anti-tumor activity. However, Tet and Fan are not suitable for clinical application due to their high effective doses.
Results
Through chemical modification, 19 novel Tet and Fan derivatives were firstly proposed and synthesized in this work, and they were assessed for the cytotoxicity against six tumor cell lines (H520, H460, HepG-2, HeLa, A549, and MCF-7) and human bronchial epithelial cells (BEAS-2b) by the CCK-8 assay. Compared to the parent Fan, ten derivatives demonstrated better cytotoxic effects, and 4b exhibited the strongest inhibitory activity against A549 cells growth (IC50 = 0.78 µM) and low toxicity against BEAS-2b cells (IC50 = 17.22 µM). Encouragingly, the IC50 value of compound 4b was 0.78 µM, demonstrating 3.53-fold, 10.22-fold and 12.13-fold more anticancer activity than HCPT, Tet and Fan, respectively. Subsequently, the anti-tumor mechanism of compound 4b was studied by hoechst 33258, flow cytometry, cell scratch, western blotting, and JC-1 staining. The results indicated compound 4b remarkably inhibited the cell migration by decreasing MMP-2 and MMP-9 expression and inhibited the proliferation of A549 cells by arresting the G2/M cell cycle. Meanwhile, compound 4b could also induce A549 cell apoptosis by promoting endogenous pathways of mitochondrial regulation. Subsequently, we simulated the drug stability of compound 4b in vivo, compound 4b showed a hydrolysis half-life of over 8 h in simulated gastric and intestinal fluids. In addition, in vivo experiments in nude mice presented that the growth of tumor tissues was markedly inhibited by the consumption of compound 4b in a dose-dependent manner, and the inhibition rate of the high-dose group (40 mg/kg) was greater than 50%. Regarding the anti-tumor mechanism of compound 4b, it was found that compound 4b could inhibit the mTOR/PI3K/AKT pathway in vivo. Furthermore, the binding mode of BCl-2 and Bax with compound 4b was investigated by performing a molecular docking study.
Conclusions
In summary, our present study unveiled the antitumor activities of 19 novel derivatives against the normal lung epithelial BESA-2b cells and six cancer cell lines in vitro. Furthermore, the following experiments illuminated that compound 4b could exert antitumor effects and induce apoptosis by regulating the PI3K/Akt/mTOR signaling pathway in vivo through triggering the mitochondria-mediated intrinsic pathways. This newly Fan derivative could exert antitumor effects in vivo and in vitro, which implied that compound 4b would be a prospective new anti-lung cancer drug for future development.
Comparative Assessment of Improved SVM Method under Different Kernel Functions for Predicting Multi-scale Drought Index
Authors: Pande Chaitanya , Kushwaha N. L. , Orimoloye Israel R. , Kumar Rohitashw , Abdo Hazem Ghassan , Tolche Abebe Debele , Elbeltagi Ahmed 
Published: September 2022

Abstract
Precise assessment, monitoring and forecasting of drought phenomena are crucial and play a vital role in agriculture and water resources management in the semi-arid region. In this study, Standardized Precipitation Index (SPI) was used to predict the drought in the upper Godavari River basin, India. Ten combinations were used to predict three SPI timescales (i.e., SPI − 3, SPI-6, and SPI-12). The historical data of SPI from 2000 to 2019 was divided into training (75% of the data) and testing (25% of the data) models for SPI prediction. The best subset regression method and sensitivity analysis were applied to estimate the most effective input variables for estimation of SPI 3, 6, and 12. The improved support vector machine using sequential minimal optimization (SVM-SMO) with various kernel functions i.e., SMO-SVM poly kernel, SMO-SVM Normalized poly kernel, SMO-SVM PUK (Pearson Universal Kernel) and SMO-SVM RBF (radial basis function) kernel was developed to estimate the SPI. The results were compared and analyzed using statistical indicators i.e., root mean square error (RMSE), mean absolute error (MAE), relative absolute error (RAE), root relative squared error (RRSE), and correlation coefficient (r). The main results showed that the SMO-SVM poly kernel model precisely predict the SPI-3 (R2 = 0.819) and SPI-12 (R2 = 0.968) values at Paithan station; the SPI-3 (R2 = 0.736) and SPI-6 (R2 = 0.841) values at Silload station, respectively. The SMO-SVM PUK kernel showed superiority in the prediction of SPI-6 (R2 = 0.846) at Paithan station and SPI-12 (R2 = 0.975) at the Silload station. The competition between SVM-SMO poly kernel and SVM-SMO PUK kernel was observed in the prediction of long setting time (i.e. SPI-6 and SPI-12), while SVM-SMO poly kernel is superior in the estimation of SPI-3 at both stations. The results of the study showed the efficacy of the SVM-SMO algorithm with various kernel functions in the estimation of multiscale SPI and can be helpful in decision making for water resource management and tackle droughts in the semi-arid region of central India.
LINC01137 facilitate pancreatic cancer stemness via the miR-7155-5p/KLF12/AKT axis
Authors: Li Kexian , Feng Zengyu , Qin Kai , Ma Yang , Zhao Shiwei , Chen Peng , Lin Jiewei , Jiang Yongsheng , Han Lijie , Cao Yizhi , Luo Jiaxin , Shi Minmin , Chen Hao , Wang Jiancheng , Jiang Lingxi , Peng Chenghong 
Published: September 2022

Abstract
Background
Pancreatic cancer, of which pancreatic ductal adenocarcinoma (PDAC) is one of the most prevalent type, is one of the most malignant tumors, with a 5-year survival rate of about 10%. Pancreatic cancer stem cells play pivotal roles in chemoresistance and recurrence. Long non-coding RNAs (lncRNAs) have been identified as key regulators of the biological progression of various cancers. LncRNAs were found to be associated with cancer stem cells, which are related to chemoresistance. LINC01137 has been reported as an oncogene in oral squamous cell carcinoma, and bioinformatic analysis found it associated with pancreatic cancer stem cells. This study is aim to discover the function and the underlying mechanism of LINC01137 in pancreatic cancer.
Results
LINC01137 was pancreatic cancer stem cell-associated lincRNA and associated with stem genes. LINC01137 was upregulated in pancreatic cancer tissues and cell lines. Its high expression correlated with poor prognosis. Knockdown of LINC01137 expression reduced pancreatic cancer stemness, chemoresistance, and proliferation. Mechanistically, LINC01137 mostly located in cytoplasm and exerted its biological function by binding to miR-7155-5p to activate the KLF12/PI3K/AKT pathway. KLF12 also promoted LINC01137 expression. LINC01137 and KLF12 were involved in promoting PDAC tumorigenesis.
Conclusion
Our results suggested that LINC01137 functions as an oncogene in pancreatic cancer and identified its post-transcriptional regulatory mechanisms, which may contribute to targeted therapy for pancreatic cancer.