bluuebunny/crossref_metadata_2025_split huggingface dataset:
Application of failure mode and effects analysis to validate a novel hybrid Linac QC program that integrates automated and conventional QC testing
Authors: Pearson Michael , Butterworth Victoria , Misson‐Yates Sarah , Naeem Marium , Gonzalez Vaz Regina , Eaton David , Greener Tony 
Published: December 2022

AbstractA hybrid quality control (QC) program was developed that integrates automated and conventional Linac QC, realizing the benefits of both automated and conventional QC, increasing efficiency and maintaining independent measurement methods. Failure mode and effects analysis (FMEA) was then applied in order to validate the program prior to clinical implementation. The hybrid QC program consists of automated QC with machine performance check and DailyQA3 array on the TrueBeam Linac, and Delta4 volumetric modulated arc therapy (VMAT) standard plan measurements, alongside conventional monthly QC at a reduced frequency. The FMEA followed the method outlined in TG‐100. Process maps were created for each treatment type at our center: VMAT, stereotactic body radiotherapy (SBRT), conformal, and palliative. Possible failure modes were established by evaluating each stage in the process map. The FMEA followed semiquantitative methods, using data from our QC records from eight Linacs over 3 years for the occurrence estimates, and simulation of failure modes in the treatment planning system, with scoring surveys for severity and detectability. The risk priority number (RPN) was calculated from the product of the occurrence, severity, and detectability scores and then normalized to the maximum and ranked to determine the most critical failure modes. The highest normalized RPN values (100, 90) were found to be for MLC position dynamic for both VMAT and SBRT treatments. The next highest score was 35 for beam position for SBRT, and the majority of scores were less than 20. Overall, these RPN scores for the hybrid Linac QC program indicated that it would be acceptable, but the high RPN score associated with the dynamic MLC failure mode indicates that it would be valuable to perform more rigorous testing of the MLC. The FMEA proved to be a useful tool in validating hybrid QC.
Intrinsic Interfacial Dynamic Engineering of Zincophilic Microbrushes via Regulating Zn Deposition for Highly Reversible Aqueous Zinc Ion Battery
Authors: Huang Tieqi , Xu Kui , Jia Ning , Yang Lan , Liu Hongtao , Zhu Jixin , Yan Qingyu 
Published: December 2022

AbstractAqueous rechargeable zinc ion batteries are promising efficient energy storage systems due to remarkable safety and satisfactory capacity. However, zinc metal anode instability including dendrite growth and side reactions severely hinders widespread applications. Herein, zincophilic microbrushes have been in situ anchored on zinc plates through simple freeze‐drying and mild reduction of graphene oxide, successfully overcoming these thorny issues. By introducing suitable oxygen‐containing groups, the microbrushes exhibit a good affinity for zinc ions, thereby providing sufficient depositing sites, promoting zinc plating and stripping during cycling, and suppressing side reactions. The delicate zincophilic microbrushes can not only function as protective layer to guide the deposition of zinc ions, but also act as high‐speed pathways to redistribute the zinc ion flux for rapid kinetics. Consequently, the microbrushes‐covered zinc anode displays long lifespan and good durability, whenever in symmetric cell or full battery tests. This work paves a feasible bridge to design advanced aqueous anodes by architecting both structures and compositions of metal coverings.
Fast, Multi‐Bit, and Vis‐Infrared Broadband Nonvolatile Optoelectronic Memory with MoS2/2D‐Perovskite Van der Waals Heterojunction
Authors: Lai Haojie , Lu Zhengli , Lu Yueheng , Yao Xuanchun , Xu Xin , Chen Jian , Zhou Yang , Liu Pengyi , Shi Tingting , Wang Xiaomu , Xie Weiguang 
Published: December 2022

AbstractNonvolatile optoelectronic memory (NVOM) integrating the functions of optical sensing and long‐term memory can efficiently process and store a large amount of visual scene information, which has become the core requirement of multiple intelligence scenarios. However, realizing NVOM with vis‐infrared broadband response is still challenging. Herein, the room temperature vis‐infrared broadband NVOM based on few‐layer MoS2/2D Ruddlesden–Popper perovskite (2D‐RPP) van der Waals heterojunction is realized. It is found that the 2D‐RPP converts the initial n‐type MoS2 into p‐type and facilitates hole transfer between them. Furthermore, the 2D‐RPP rich in interband states serves as an effective electron trapping layer as well as broadband photoresponsive layer. As a result, the dielectric‐free MoS2/2D‐RPP heterojunction enables the charge to transfer quickly under external field, which enables a large memory window (104 V), fast write speed of 20 µs, and optical programmable characteristics from visible light (405 nm) to telecommunication wavelengths (i.e., 1550 nm) at room temperature. Trapezoidal optical programming can produce up to 100 recognizable states (>6 bits), with operating energy as low as 5.1 pJ per optical program. These results provide a route to realize fast, low power, multi‐bit optoelectronic memory from visible to the infrared wavelength.
Ti3C2Tx MXene‐Based Superhydrophobic Broadband Terahertz Absorber with Large Pore‐Size Foam Architecture
Authors: Luo Min , Guo Junchang , Shui Wenchao , Tan Yao , Huang Haoming , Yang Qinghui , Zhang Huaiwu , Deng Xu , Wen Qi‐Ye 
Published: December 2022

AbstractPorous polymer‐based Terahertz (THz) absorbers possess strong absorption with broadband, lightweight, and flexible features. Thus these are widely desired in THz electromagnetic shielding, radar‐cross‐section reduction, radiometer calibration, etc. However, the harsh environment of humidity, corrosiveness, and dustiness undermines the performance and service lifetime of the porous absorbers. Here, based on Ti3C2Tx MXene sponge composite foam (MSF), a superhydrophobic broadband THz absorber on a large pore‐size porous architecture by a joint hydrophobic strategy is realized. Results show that the apparent contact angles and roll‐off angles of the modified MSF reached 159.0° and 7.6°, while maintaining an ultra‐high absorption rate of 99.6% in the frequency range of 0.3–1.2 THz. Furthermore, the special Micro‐Nano hierarchical structures render the absorber a strong bounce‐off ability to the droplets of an aqueous solution. These water‐repellent properties endow the absorber the versatility of self‐cleaning and anti‐corrosion, thus can be widely applied in many scenarios including THz remote sensing, communication, and security screening as well.
An Environmental‐Inert and Highly Self‐Healable Elastomer Obtained via Double‐Terminal Aromatic Disulfide Design and Zwitterionic Crosslinked Network for Use as a Triboelectric Nanogenerator
Authors: Chou Syun‐Hong , Lu Hong‐Wei , Liu Ta‐Chung , Chen Yi‐Ting , Fu Yen‐Lin , Shieh Yung‐Hsin , Lai Ying‐Chih , Chen San‐Yuan 
Published: December 2022

AbstractDue to the ongoing development of portable/mobile electronics, sources to power have received widespread attention. Compared to chemical batteries as power sources, triboelectric nanogenerators (TENGs) possess lots of advantages, including the ability to harvest energy via human motions, flexible structures, environment‐friendliness, and long‐life characteristics. Although many self‐healable TENGs are reported, the achievement of a muscle‐like elasticity and the ability to recover from inevitable damage under extreme conditions (such as a high/low temperature and/or humidity) remain a challenge. Herein, a “double‐terminal aromatic disulfide” on a structure with zwitterions as branched chains is reported to engineer the high‐efficient self‐healable elastomer for application in a flexible TENG. The as‐designed material exhibits a repeatable elastic recovery (at 250% elongation) and a self‐healing efficiency with an ultimate tensile stress of 96% over 2 h, representing an improvement on previously reported disulfide‐based elastomers. The elastomer can autonomously recover by 50% even at a subzero temperature of −30 °C within 24 h. The elastomer‐based TENG, as a self‐driven sensor for detecting human behavior, is demonstrated to exhibit stable outputs and self‐healing in the temperature range of −30 to 60 °C, and so is expected to promote the development of self‐powered electronics for next‐generation human–machine communications.
Deterministic Single Cell Encapsulation in Asymmetric Microenvironments to Direct Cell Polarity
Authors: Cho Ik Sung , Gupta Prerak , Mostafazadeh Nima , Wong Sing Wan , Saichellappa Saiumamaheswari , Lenzini Stephen , Peng Zhangli , Shin Jae‐Won 
Published: December 2022

AbstractVarious signals in tissue microenvironments are often unevenly distributed around cells. Cellular responses to asymmetric cell‐matrix adhesion in a 3D space remain generally unclear and are to be studied at the single‐cell resolution. Here, the authors developed a droplet‐based microfluidic approach to manufacture a pure population of single cells in a microscale layer of compartmentalized 3D hydrogel matrices with a tunable spatial presentation of ligands at the subcellular level. Cells elongate with an asymmetric presentation of the integrin adhesion ligand Arg‐Gly‐Asp (RGD), while cells expand isotropically with a symmetric presentation of RGD. Membrane tension is higher on the side of single cells interacting with RGD than on the side without RGD. Finite element analysis shows that a non‐uniform isotropic cell volume expansion model is sufficient to recapitulate the experimental results. At a longer timescale, asymmetric ligand presentation commits mesenchymal stem cells to the osteogenic lineage. Cdc42 is an essential mediator of cell polarization and lineage specification in response to asymmetric cell‐matrix adhesion. This study highlights the utility of precisely controlling 3D ligand presentation around single cells to direct cell polarity for regenerative engineering and medicine.
Discrepancy between the crop yield goal rate and the optimum nitrogen rates for maize production in Mississippi
Authors: Oglesby Camden , Dhillon Jagmandeep , Fox Amelia , Singh Gurbir , Ferguson Connor , Li Xiaofei , Kumar Ramandeep , Dew James , Varco Jac 
Published: December 2022

AbstractThe varying influence of the environment on N supply and demand dictates the need for annually updated fertilizer N recommendations. Currently, crop yield goal (CYG) methods are used by 34 land grant universities, including Mississippi State University, these do not consider environmental variations. This research tested the efficacy of CYG by determining the agronomic optimum N rate (AONR) and the economic optimum N rate for Mississippi corn (Zea mays L.) production. In total, 12 treatments in 2020 and 11 in 2021 were replicated four times over four locations in a randomized complete block design. The optimum N rates were calculated by fitting linear, quadratic, linear plateau, and quadratic plateau models by means of three different goodness of fit measures. Furthermore, differences between the CYG rate calculated from the Mississippi yield goal equation and AONR were compared at different management levels (14 comparisons) (all data combined, both years combined, sites combined by year, and individual sites). Overall, AONR varied from 134 to 301 kg N ha–1 at different management levels. When we compared the AONR to the CYG rate, the CYG rate over‐recommended N in 12 of the 14 possible comparisons, with differences ranging from 69 kg N ha–1 less to 110 kg N ha–1 greater than the AONR. These differences between AONR values highlight variability caused by factors such as the soil, environment, and their interaction with N supply and demand, which are unaccounted for by the CYG method.
Copper‐Catalyzed Regio‐ and Diastereoselective Borylacylation ofα,β‐Unsaturated Esters
Authors: Nishino Soshi , Hirano Koji 
Published: December 2022

AbstractA copper‐catalyzed regio‐ and diastereoselective borylacylation ofα,β‐unsaturated esters with B2pin2and acyl fluorides has been developed to afford theβ’‐boryl‐β‐ketoesters with highanti‐diastereoselectivity (up to >99 : 1). Additionally, the borylcarbamoylation is possible by using isocyanates as electrophiles instead of acyl fluorides. Moreover, the enantioselective borylacylation and borylcarbamoylation are also achieved by judicious choice of a chiral phosphoramidite‐ligated copper complex.
Evaluation of direct intramural injection to the bladder wall as a method for developing orthotopic tumor models
Authors: Bitaraf Masoud , Muhammadnejad Samad , Azimzadeh Ashkan , Tanourlouee Saman Behboodi , Amini Erfan , Zolbin Masoumeh Majidi , Kajbafzadeh Abdol‐Mohammad 
Published: December 2022

AbstractBackgroundBladder cancer poses a great burden on society and its high rate of recurrence and treatment failure necessitates use of appropriate animal models to study its pathogenesis and test novel treatments. Orthotopic models are superior to other types since they provide a normal microenvironment. Four methods are described for developing bladder cancer models inside the animal's bladder. Direct intramural injection is one of these methods and is widely used. However, its efficacy in model development has not yet been studied. We aimed to evaluate the efficacy and success rate of the direct intramural injection method of developing an orthotopic model for the study of bladder cancer.MethodTumor cell lines were prepared in four microtubes. Aliquots of 200 × 103 cells were injected through a 27 gauge needle into the ventral wall of the bladders of 4 male and 4 female BALB/c mice following a midline 1 cm laparotomy incision. In addition, 1 million cells from each microtube were injected into the flanks of control mice. To prevent infection and alleviate pain, 5 mg/kg enrofloxacin and 2.5 mg/kg flunixin meglumine, respectively, were injected subcutaneously.ResultsTumors formed in all mice, resulting in 100% take rate and zero post‐operation mortality. Surgery time was ≤15 min per mouse. In two mice, tumors were found in the peritoneal space as well.ConclusionDirect intramural injection is a rapid, reliable, and reproducible method for developing orthotopic models of bladder cancer. It can be done on both male and female mice and only requires readily available surgical tools. However, needle track can result in cell spillage and peritoneal tumors.
Wisdom from words: The psychology of consumer language
Authors: Berger Jonah , Packard Grant 
Published: December 2022

AbstractLanguage plays a fundamental role in every aspect of life. But only recently has research begun to understand the role of language in consumer behavior. This paper offers an integrative discussion of research on the language of consumer psychology. We review some of the main areas of inquiry and discuss some key methodological approaches (e.g., automated textual analysis) that have been crucial to the area's development. Further, we outline some broad issues and opportunities in the space and highlight potential directions for future research. We hope to encourage more consumer psychologists to consider the great potential in producing new conceptual and substantive wisdom from words.
Omics combined with network pharmacology reveal the neuroprotective mechanism of Sophora tonkinensis based on the biolabel research pattern: The treatment of Parkinson’s disease against oxidative stress and neuroexcitatory toxicity
Authors: Zhang Shuai‐nan , Li Hong‐mei , Liu Qi , Li Xu‐zhao , Yang Wu‐de , Zhou Ying 
Published: December 2022

AbstractBased on the biolabel research pattern, omics and network pharmacology were used for exploring the neuroprotection of Sophora tonkinensis (ST) in the treatment of brain diseases. Multi‐omics were applied to investigate biolabels for ST intervention in brain tissue. Based on biolabels, the therapeutic potential, mechanism and material basis of ST for treating brain diseases were topologically analyzed by network pharmacology. A Parkinson’s disease (PD) mouse model was used to validate biolabel analysis results. Four proteins and three metabolites were involved in two key pathways (alanine, aspartate and glutamate metabolism and arginine biosynthesis) and considered as biolabels. Network pharmacology showed that ST has the potential to treat some brain diseases, especially PD. Eight compounds (including caffeic acid, gallic acid and cinnamic acid) may serve as the material basis of ST treating brain diseases via the mediation of three biolabels. In the PD model, ST and its active compounds (caffeic acid and gallic acid) may protect dopaminergic neurons (maximum recovery rate for dopamine, 49.5%) from oxidative stress (E3 ubiquitin‐protein ligase parkin, reactive oxygen species, nitric oxide, etc.) and neuroexcitatory toxicity (glutamate dehydrogenase, glutamine, glutamic acid, etc.). These findings indicated that omics and network pharmacology may contribute to the achievement of the objectives of this study based on the biolabel research pattern.
Assessing symptom exaggeration of psychopathology in incarcerated individuals and mentally ill offenders within forensic contexts
Authors: Arin Natthawut , Mengchuay Jiraporn 
Published: December 2022

AbstractIn forensic contexts, there is a high probability that offenders may exaggerate illness to avoid legal punishment. Since very few empirical studies presently exist on this matter in Thailand, the objectives are to explore the prevalence rate of the exaggeration of psychopathological symptoms and to examine the detection strategy response styles for Thai version of the Symptom validity test (SVT‐Th). An analysis of the factors that influence symptom exaggeration would also be included. Mixed participants included 608 individuals consisting of 528 Incarcerated individuals and 80 Mentally Ill Offenders (MIOs). SVT‐Th indicated the prevalence rates of feigned psychopathology among overall offenders were 8.88%, 3.20% for incarcerated individuals, and 46.30% for MIOs. As expected, the endorsed average scores of the psychopathological symptoms using the Amplifier and Unlikely response style were recorded at similar amounts. Offenders with a history of mental illness exaggerated their symptoms to a greater degree than those without a history of mental illness. With regard to the type of crime and the number of offenses, no discrepancies of statistical significance were found. Interestingly, offenders who committed violent crimes, and with more than four times the number of offenses, were more likely to exaggerate their symptoms than the other subjects.
Layer‐by‐layer interleukin‐12 nanoparticles drive a safe and effective response in ovarian tumors
Authors: Barberio Antonio E. , Smith Sean G. , Pires Ivan S. , Iyer Sonia , Reinhardt Ferenc , Melo Mariane B. , Suh Heikyung , Weinberg Robert A. , Irvine Darrell J. , Hammond Paula T. 
Published: December 2022

AbstractOvarian cancer is especially deadly, challenging to treat, and has proven refractory to known immunotherapies. Cytokine therapy is an attractive strategy to drive a proinflammatory immune response in immunologically cold tumors such as many high grade ovarian cancers; however, this strategy has been limited in the past due to severe toxicity. We previously demonstrated the use of a layer‐by‐layer (LbL) nanoparticle (NP) delivery vehicle in subcutaneous flank tumors to reduce the toxicity of interleukin‐12 (IL‐12) therapy upon intratumoral injection. However, ovarian cancer cannot be treated by local injection as it presents as dispersed metastases. Herein, we demonstrate the use of systemically delivered LbL NPs using a cancer cell membrane‐binding outer layer to effectively target and engage the adaptive immune system as a treatment in multiple orthotopic ovarian tumor models, including immunologically cold tumors. IL‐12 therapy from systemically delivered LbL NPs shows reduced severe toxicity and maintained anti‐tumor efficacy compared to carrier‐free IL‐12 or layer‐free liposomal NPs leading to a 30% complete survival rate.
Chemical Composition and in Vitro Antioxidant, Anti‐Alzheimer, Anti‐Diabetic, Anti‐Tyrosinase, and Antimicrobial Properties of Essential Oils and Extracts Derived from Various Parts of the Algerian Calendula Suffruticosa Vahlsubsp. boissieri Lanza
Authors: Samai Zakaria , Toudert Nadia , Djilani Salah Eddine , Dadda Noureddine , Zakkad Farida , Hamel Tarek 
Published: December 2022

AbstractCalendula suffruticosa Vahl subsp. boissieri Lanza is well‐known for its medicinal properties in northeastern Algeria. As far as literature has been able to prove, no study has attempted to make a phytochemical or biological activity evaluation (antioxidants, enzyme inhibitors and antimicrobial potential). This work intends to evaluate, for the first time, the chemical constituents and study the previously mentioned biological activities of C. suffruticosa boissieri essential oil and different sections (flowers, leaves, roots) as well as the effect of changing the solvent (ethanol 70 %) and (methanol 70 %) on these activities. The essential oil of aerial parts of this plant was investigated using GC/MS, and 45 compounds were discovered, accounting for 98.01 % of the essential oil, including 23 monoterpenes, 6 sesquiterpenes, 12 diterpenes, 1 coumarin, 3 alkanes, methyl‐cyclohexane (23.73 %), limonene (25.02 %), and o‐cymene (13.20 %). Five methods were used to study the antioxidant activity (ABTS, DPPH, CUPRAC, reducing power, and β‐carotene bleaching assay), where the results were impressive, especially for the essential oil. In addition, the hydroethanolic solvent (70 %) was found to be the most effective solvent for extraction in general compared to the hydromethanolic solvent (70 %). The extracts and essential oils of C. suffruticosa boissieri also showed a strong inhibiting ability against cholinesterase, tyrosinase, anti‐α‐amylase, α‐glucosidase, and antimicrobials, a very valuable antioxidant, which is a real discovery. Based on these results, it can be said that this plant has important biological activities, so it can be used in the phytotherapy, food, or pharmaceutical sectors.
A Modular Olefination of Aldehydes with Thiols as Coupling Partners
Authors: Bognar Sabine , van Gemmeren Manuel 
Published: December 2022

AbstractOlefins range amongst the most important motifs in organic chemistry. Hence, the development of novel olefin syntheses has remained a constant field of research in synthetic chemistry to date. Herein, we report the development of a modular olefination that converts aldehydes into olefins with thiols as reaction partners. The simple, transition metal‐free protocol proceeds via an unsymmetrical bissulfone intermediate which is converted into the respective alkene in a Ramberg‐Bäcklund‐type process. Differently substituted olefins can be synthesized from readily available starting materials in typically good yields and stereoselectivities using basic laboratory chemicals exclusively. Complementary reaction conditions differing in the choice of solvent favor the E/Z‐products respectively under kinetic control rendering this protocol an interesting economical addition to the family of olefin syntheses.
ACHEMA 2022 – Heat Exchanger
Authors: Hohm Manuel 
Published: December 2022

AbstractACHEMA is an international exhibition for innovation and development in the process industry. Heat exchangers are necessary parts of many process engineering plants. This report intends to highlight the presented novelties in relation to heat exchangers at ACHEMA 2022. The trends and challenges of heat exchangers were explored in discussions with exhibitors and through presentations at the congress. The field of application for heat exchangers broadens as well as their performance increases. Existing designs are enhanced, traditional types of heat exchangers are combined, and software is developed based on both traditional models and artificial intelligence. An overview of relevant innovations and developments in heat exchangers is given.