bluuebunny/crossref_metadata_2025_split huggingface dataset:
Terapi Sel Punca sebagai Inovasi dalam Pengobatan Penyakit Autoimun untuk Mempertahankan Sistem Imunitas Tubuh Manusia
Authors: Simatupang Elysabeth , Purba Pahotkon , Juliana Sherina , Ayustin Yohana , Irawati Wahyu 
Published: May 2022

Autoimmune is a disease caused by imbalance of immunology and losing tolerance then causes autoimmunity to attack body tissues in organisms. This disease occurs when the self-antigens attached by adaptive immune response. This disease can be treated by stem cell therapy. Stem cell therapy is an assured alternative to autoimmune treatment. Stem cells that can differentiate or can change themselves into various cells according to the environment and function to replace the damaged body cells. This study aims to find out the utility of stem cell therapy as an innovation in the treatment of autoimmune diseases. Literasture review is the method used in this research and focus to discuss: 1) the body's immune system; 2) immune system disorders; 3) autoimmune disease mechanisms; and 4) Stem cell therapy as an alternative to autoimmune treatment. Through this paper, readers will know that there is one technology to use treating autoimmune diseases, stem cell therapy. The mechanism of utilisation of stem cell therapy varies with each type of autoimmune disease, but this therapy can also cause some side effects. Stem cell therapy repairs damaged cells and replaces them with new, more functional ones.Â Key words: autoimmune disease; stem cell therapy; human body; medication.
STUDI PERLINDUNGAN HUKUM BAGI PEKERJA ANAK (Studi Kasus UU No. 13 Tahun 2003 dalam Tinjauan Fiqh Siyasah di Kota Tebing Tinggi)
Authors: M Rizal  
Published: May 2022

Masa usia anak sebagai generasi penerus bangsa tidak terlepas dari berbagai problematika kehidupan. Adanya tuntutan ekonomi keluarga memaksa anak untu turut andil bekerja demi terpenuhinya kebutuhan keluarga. Tingginya jumlah anak yang bekerja mayoritas berusia kurang dari 15 tahun baik di sector formal maupun informal merupakan fenomena yang tidak biasa lagi. Maka dari itu, pemerintah mengeluarkan kebijakan hukum yang bertujuan untuk memberi perlindungan bagi anak-anak yang memikul beban ekonomi sebagai bentuk bakti kepada keluarga. Namun, dalam pelaksanaaannya banyak tragedy yang tidak diharapkan dari kebijakan hukum tersebt. Upaya pemerintah dalam melindungi pekerja anak belum seutuhnya terlaksana. Hal ini dikarenakan oleh kurangnya pemahaman masyarakat dalam menjalankan perlindungan hukum yang berlaku bagi pekerja anak. Penelitian ini merupakan penelitian deskriptif yang bertujuan untuk menggambarkan kesesuaian perlindungan hukum bagi pekerja anak menurut UU No. 13 Tahun 2003. Penelitian ini dilaksanakan di salah satu usaha di Kota Tebing Tinggi yaitu CV. Lima Manis. Teknik pengumpulan data dilakukan dengan wawancara dan observasi. Hasil penelitian ini menunjukkan bahwa CV lima Manis telah menerapkan beberapa ketentuan hukum yang tertera dalam UU No. 13 tahun 2003 khususnya di pasal 69 ayat 2. Di samping itu, jika ditinjau dengan ketentuan islam, terkait kewajiban pengusaha terhadap pekerjanya, CV Lima Manis telah memenuhi kewajibannya sebagai penyedia lapangan pekerjaan dalam hal pemberian keringanan pekerjaan sesuai dengan kemampuan anak, pemberian gaji yang sesuai pada waktunya, serta terpenuhinya syarat serta rukun dalam Ijarah.
Efficacy, tolerability and safety study of zinc hyaluronan for dogs with osteoarthritis
Authors: Maryushina T. O. , Kryukovskaya G. M. , Matveeva M. V. , Kulikovskiy S. A. , Davydov E. V. 
Published: May 2022

Relevance. In recent years, the problems of arthrology have become more relevant among domestic and farm animals. The significance of the article is due to the fact that in the Russian market of veterinary drugs, there is obviously a small number of drugs for the treatment of various pathologies of the joints, created on the basis of hyaluronic acid.Methods. 32 dogs of different sexes and breeds aged from 8 to 13 years with destructive-degenerative pathologies of the joints were selected for the study. Animals were treated with hyaluronic acid with zinc. Research methods: hematological analysis, general clinical examination.Results. In the process of drug therapy, in 81.25% of dogs was noted an increase in motor activity. Also, 7 days after the 5th injection of the drug, there was a significant decrease in the manifestations of starting pains up to their complete absence. The main positive changes in the course of arthrosis in dogs, according to all evaluation criteria, reached their maximum manifestation after 3–4th injections and remained practically unchanged by the 5th injection. The results of a biochemical study of blood serum indicate that against the background of the use of the drug in dogs with osteoarthritis, no significant changes were found that characterize the main types of metabolism. According to the results of hematological studies, it can be noted that in dogs receiving therapy with hyaluronic acid with zinc, there is a steady positive trend in a number of hematological parameters. So, a week after the 5th injection of the “Drug” there was a decrease in the total number of platelets. The percentage of eosinophils in the leukocyte formula stabilized to the upper values of the reference range. It is appropriate to emphasize that the “Drug” does not exhibit the properties of an antigen, and has a pronounced anti-inflammatory effect.
Method of resource potential management for efficient grain growing in the agricultural landscapes of Siberia
Authors: Utenkov G. L. , Utenkova T. I. , Vlasenko A. N. , Koteev S. V. 
Published: May 2022

Relevance. The solution of social problems caused by food production, as well as the creation of jobs in rural populations are the main functional feature of the crop growing industry in the agro-industrial complex. Moreover, grain production per capita in the amount of 1-1.2 t/person is the basis for a prosperous future for Russia. In the emerging market relations, the competitiveness of the products produced is determined by their price and quality. However, not all is well in grain production: it remains extensive, energy-intensive and ecologically unbalanced. To conduct extended reproduction, the level of profitability should be 25-30%. Low and unstable profitability of agriculture, as well as the frequent unpredictability of the volume of government support, create problems in the development of the industry. And the percentage increase in the efficiency of the cultivation of grain crops does not give the desired results. The purpose of the research is to substantiate the method of managing the resource potential of agrolandscapes by mechanical and technological solutions based on the detection of significant soil-climatic factors affecting the yield of grain crops and creating the necessary conditions for a more complete implementation of their genetic potential, which is expressed by the creation of a chain of an additional product that determines the efficiency of the cultivation of grain cultures in Siberia.Methods. The studies are based on a systematic approach, the methods of the hierarchy and synthesis, methods of mathematical statistics and differential calculus, experimental methods.Results. For quantitative assessment and accounting of the actions of natural and climatic conditions, an analytical expression is proposed of the possible amount of yield for the cultivation of grain crops. As the control effects, to obtain a given average level of the yield of grain crops (at least 3.0 t/ha) in agrolandscapes, a rational structure recommended for the conditions of Siberia of three levels of intensity of agrotechnologies is proposed: extensive — 31.0%; normal — 49.0%; intense — 20.0%. The algorithm of their synthesis is developed. The proposed methodological approaches and mechanical and technological solutions contribute to a decrease in the “contrast” of the current situation through a rational hierarchical management of the structure of consumed resources in Siberian agrolandscapes to obtain an additional grain product.
Influence of clonal rootstocks on the production process of plum variety Stanley in arid conditions of the Astrakhan region
Authors: Alexandrova T. I. 
Published: May 2022

Relevance. The article presents the results of a three-year study of the economic and biological characteristics of the Stanley plum variety (growth and development of plants, the time of fruiting, productivity, yield, marketable qualities of fruits) when grown on medium-sized clonal rootstocks Evrika-99 and Druzhba, bred at the Crimean experimental breeding station named after N.I. Vavilov, in the acutely arid conditions of the Astrakhan region.Methods.The purpose of the research was to study the influence of medium-sized clonal rootstocks on the production process of the Stanley plum variety in the natural and climatic conditions of the Astrakhan region and to substantiate the possibility of their use for laying intensive plum plantations in the arid conditions of the Northern Caspian Sea.Results. In the course of the research, the influence of the rootstock genotype on the main indicators of productivity was revealed: precocity, yield, commercial qualities of fruits. The early fruiting of the variety was most influenced by the medium-sized rootstock Evrika-99, on which already in the first year of growth in the garden 60-80% of plum trees were noted to bloom. Among the studied rootstocks, the highest rates of yield increase in the Stanley variety were noted on the medium-sized rootstock Evrika-99, in combination with which the variety was characterized by the maximum values of the average yield of 7.6 t/ha, with the values of this indicator on the rootstock Druzhba — 6.7 t/ha , which is 11.8% higher. According to the marketability of the fruit, the rootstock Druzhba was noted, the average weight of which was 48.2 g, which is 18.1% more than on the stock Eureka-99 (40.8 g). In the extremely dry conditions of the Astrakhan region, the Stanley variety is recommended to be grown in an intensive garden on the rootstocks Evrika-99 and Druzhba, which ensure regular and stable yields.
Morphology of the adrenal gland blue rock pigeon (Columba livia L.)
Authors: Prokopenko V. 
Published: May 2022

The blue rock pigeon (Columba livia L.) is a cosmopolitan, synanthropic or urbanist bird. Its use as a biological model to clarify the features of the structure of organs, systems and devices is incomplete. The adrenal gland plays an important role in the body of birds. Its hormones affect the growth and differentiation of tissues, regulate metabolism, affect the body's resistance to infections, stress, intoxication, low temperatures. The aim of the work was to find out the features of the morphology of the adrenal gland of the blue rock pigeon. Anatomical, histological, morphometric and statistical research methods were used. It was found that in the blue rock pigeon, the adrenal gland is a paired organ located ventrally from the cranial lobe of the kidneys. It has a pale yellow color, elongated-pyramidal or elongated-rounded shape, absolute mass of 0.019 ± 0.001 g. of the linear dimensions of the adrenal gland of the blue rock pigeon, the largest is the length (3.53 ± 0.04 mm), slightly smaller – the width (2.59 ± 0.16 mm), the smallest – the thickness (1.33 ± 0.03 mm). The left adrenal gland is longer and wider than the right adrenal gland. The adrenal parenchyma of the blue rock pigeon is represented by cellular strands of interrenal and suprarenal tissues, which are intertwined with each other. Indicators of their relative area in the peripheral zone (71.50 ± 3.46 and 25.83 ± 3.51 %, respectively), compared with the central zone (71.00 ± 3.50 and 26.17 ± 3.56 %, respectively), do not differ. Cells of the interrenal tissue of the adrenal gland of the blue rock pigeon are columnar or cubic in shape, with an eosinophilic colored cytoplasm and a rounded or oval nucleus, which is placed eccentrically. Relative to the cells of suprarenal tissue, they have a polygonal shape, basophilic cytoplasm, and a rounded, centrally located nucleus. Venous sinuses are registered between the cell strands of interrenal and suprarenal tissues. The wall of the venous sinuses is formed by flat endotheliocytes, in some places sinusoidal hemocapillaries invaginate in it. The relative area of venous sinuses in the peripheral and central zones of the adrenal gland of the blue rock pigeon is almost the same – 2.67 ± 0.33 and 2.83 ± 0.48 %, respectively. Clusters of multipolar neurons and nodes of the autonomic nervous system are recorded in the capsule, parenchyma, or outside the adrenal capsule of the blue rock pigeon. The established features of the macro- and microscopic structure, morphometric indicators of the adrenal gland of the blue rock pigeon can be used to create a base for its normal morphological characteristics, which will make it possible to assess the Morpho-functional state of the adrenal gland of birds of this species under the influence of various factors and pathology.
Comparison of different staining methods for the nematode Strongyloides papillosus isolated from rabbits
Authors: Duda Y. V. 
Published: May 2022

Strongyloidiasis in rabbits is a disease caused by Strongyloides papillosus helminths, manifested by skin inflammation, diarrhea, weight loss, and stunting of animals in growth and development. Confirmation of invasion is carried out mainly by required methods of helminthoovoscopy and helmintholarvoscopy. The most well-known methods of helmintholarvoscopic diagnosis of feces for strongyloidiasis are the method of D. Baermann (1917) and its modifications according to V. I. Shilnikov (1983), the method using the “asterisk” device (according to V. F. Nikitin and T. Pavlasek, 1988), the method of coprohelmintho-larvoscopic rings (according to S. I. Ponomar, N. M. Soroka, 2007), the method of T. I. Popova, standardized by S. I. Ponomar (2003). There are no laboratory methods with 100 % reliability at the present stage. Therefore, our studies on improving the lifelong helminthocoprological diagnosis of strongyloidiasis in rabbits are relevant. Our work aimed to compare different methods of staining the pathogen S. papillosus. Laboratory studies were carried out in the laboratories of the Department of Parasitology and Veterinary Sanitary Expertise of the Dnipro State Agrarian and Economic University. For staining S. papillosus, 20 dyes were used: 1 % alizarin red, 1 % brilliant blue, Turk's solution, 1 % brilliant green, 1 % methylene blue, 1 % amido black 10B, 1 % eosin, Ziehl's solution, Lugol's solution, 1 % сarbolic gentian violet, Romanowsky-type, 1 % Sudan, 1 % bromophenol blue, 1 % orange G, 1 % bromocresol green, 1 % safranin, Zadorozhny-Dozmorov's-type, Mikhin's-type, Muromtsev's-type. We have proposed 20 dyes for staining the internal organs of larvae and free-living males and females pathogens of Strongyloides without or with temperature fixation. Live pathogens S. papillosus, without temperature fixation, pass only Lugol's and safranin's solutions. All other dyes showed the highest staining, but only when the preparation was heated for 2–3 seconds to 60 °C. However, the dyes showed different degrees of coloration. Bromocresol green stained the walls of the internal organs of the helminth. Namely, the nematodes acquired a green color, and the membranes of a part of the esophagus and intestines became dark green. During microscopy, this allowed accurate identification and differentiation into larvae and free-living males and females of S. papillosus and simplified their counting.
Câncer de laringe com HPV positivo: um estudo de caso
Authors: Zorzanelli Luisa Abreu , Tso Fernanda Kesselring , Lima Tatiana Megale de , Mattos Patricia Napoli Belfort , Lafraia Fernanda Marino , Trevizo Juliana Pagotto , Speck Neila Maria de Góis 
Published: May 2022

Na atualidade a prevalência de neoplasia maligna da cavidade oral, em especial o carcinoma de células escamosas, tem sido mais observada. No Brasil, o câncer de boca representa a quinta neoplasia maligna mais predominante entre os homens e a sétima entre as mulheres. Além dos fatores etiológicos como o tabaco e o álcool, nos últimos anos, o Papilomavírus humano também tem sido associado ao desenvolvimento do câncer de cabeça e pescoço. Portanto, o objetivo desse estudo foi apresentar um relato de caso de diagnóstico de carcinoma de células escamosas pouco diferenciado invasivo com HPV positivo orofaringe, em paciente do sexo feminino. O caso em questão demonstra a necessidade de melhor rastreio do câncer de cavidade oral, principalmente, na população imunodeprimida.
Bioavailabilitas Mineral Ca (in vitro) pada Jagung (Zea mays L), dengan Penambahan Asam Sitrat dan Fitase Bacilus subtilis HG
Authors: Kurniawati Yulia Ratri 
Published: May 2022

Abstract. Background & Aims: Mineral Ca is the most abundant mineral in the human body. Lack of mineral Ca in the human body in the long term will result in loss and calcification. Corn is food ingredient that contains vegetable calcium, it is widely consumed by Indonesians. The purpose of the research to obtain information on the bioavailability of the mineral Ca (in vitro) in corn (Zea mays L) with the addition of citric acid and phytase’s Basillus subtilis HG isolate.Methods: The research consists of two steps. The first step is to determine the best treatment in reducing phytate acid in corn with variations of the submersion duration and the citric acid concentrate, with the variation of phytase enzyme concentrations. The second step is to determine the bioavailability of mineral Ca through in vitro proses. The data analysis used two way anova and one away anova.Results: The results of the research: 1) the best treatment to reduce phytate acid in found in the immersion of corn with 9% citric acid for 12 hours in the amount of 32.45%, whereas in the variation of the concentration of phytase enzyme 250µL/50mL in the amount 50.09%. 2) The highest bioavailability of mineral Ca through in vitro is in amount of 56.880% with 9% citric acid for 12 hours and with the increment of phytase enzyme 250µL/50mL.Conclusion: The increase in bioavailability of mineral Ca in corn (Zea mays L) was influenced by the addition of citric acid concentration, submersion duration, and the concentration of phytase enzyme. Research on mineral bioavailability can be further developed by examining other foodstuffs containing phytate acid, and carried out by more sophisticated methods and analyzed, and the methods that have been done can be used to study the degradation of phytate to other bivalent minerals.Keywords: bioavailability of mineral Ca; phytate acid; citric acid; phytase
OPTIMALISASI PENGELOLAAN, PEMANFAATAN DAN PENGAWASAN DANA DESA DALAM MENINGKATKAN PEREKONOMIAN MASYARAKAT DESA DI PROVINSI SUMATERA UTARA
Authors: Sinaga Anton Parlindungan 
Published: May 2022

Tujuan penelitian ini adalah untuk mengetahui pengelolaan, pemanfaatan dan pengawasan terhadap dana desa dalam rangka meningkatkan perekonomian masyarakat desa di Provinsi Sumatera Utara. Lokasi yang ditentukan adalah Kabupaten Deli Serdang, Kabupaten Langkat, Kabupaten Karo dan Kabupaten Batubara. Metode yang digunakan adalah kualitatif deskriptif dengan teknik pengumpulan data berupa observasi, melakukan wawancara mendalam, menyebar kuesioner dan telaah dokumentasi. Teknik analisa data yang digunakan yaitu model interaktif Miles, huberman dan Saldana meliputi tahap pengumpulan data, kondensasi data, penyajian data serta penarikan kesimpulan.

Hasil penelitian ditemukan bahwa 1) Secara keseluruhan proses pengelolaan dana desa di Provinsi Sumatera Utara telah dilakukan sesuai dengan prosedur dan aturan peraturan perundang-undangan yang meliputi tahap perencanaan, pelaksanaan, penatausahaan, pertanggungjawaban dan pelaporan. 2) Pemanfaatan dana desa digunakan untuk pembangunan desa melalui pengembangan potensi desa sebagai upaya peneingkatan PAD dan ekonomi masyarakat yaitu melalui pembentukan BUMDesa, namun masih ada keterbatasan sumber daya manusia dalam mengelolanya. 3) Pengawasan dana desa telah dilakukan sesuai dengan standard an prosedur yang diatur dalam Permendagri no. 73 tahun 2020 sehingga dapat menghasilkan optimalisasi pengawasan dana desa dan meminimalisir penyimpangan dan konflik yang terjadi dalam pengelolaan dana desa. 4) Optimalisasi pengelolaan, pemanfaatan dan pengawasan dana desa dapat diselenggarakan dengan baik melalui meningkatkan kapasitas sumber daya dan potensi desa sehingga menjadi daya dukung pengelolaan, pemanfaatan dan pengawasan serta sebagai wujud nyata implementasi kebijakan desa tahun 2014.
Integration of Bioglass Into PHBV-Constructed Tissue-Engineered Cartilages to Improve Chondrogenic Properties of Cartilage Progenitor Cells
Authors: Xue Ke , Zhang Shuqi , Ge Jin , Wang Qiang , Qi Lin , Liu Kai 
Published: May 2022

Background: The Poly (3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) scaffold has proven to be a promising three-dimensional (3D) biodegradable and bioactive scaffold for the growth and proliferation of cartilage progenitor cells (CPCs). The addition of Bioglass into PHBV was reported to increase the bioactivity and mechanical properties of the bioactive materials.Methods: In the current study, the influence of the addition of Bioglass into PHBV 3D porous scaffolds on the characteristics of CPC-based tissue-engineered cartilages in vivo were compared. CPCs were seeded into 3D macroporous PHBV scaffolds and PHBV/10% Bioglass scaffolds. The CPC–scaffold constructs underwent 6 weeks in vitro chondrogenic induction culture and were then transplanted in vivo for another 6 weeks to evaluate the difference between the CPC–PHBV construct and CPC–PHBV/10% Bioglass construct in vivo.Results: Compared with the pure PHBV scaffold, the PHBV/10% Bioglass scaffold has better hydrophilicity and a higher percentage of adhered cells. The CPC–PHBV/10%Bioglass construct produced much more cartilage-like tissues with higher cartilage-relative gene expression and cartilage matrix protein production and better biomechanical performance than the CPC–PHBV construct.Conclusion: The addition of Bioglass into 3D PHBV macroporous scaffolds improves the characteristics of CPC-based tissue-engineered cartilages in vivo.