bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pengalihan Objek Jaminan Fidusia oleh Debitur Kepada Pihak Ketiga Tanpa Persetujuan Kreditur
Authors: Lasori Siti Alfisyahrin , Yunus Yudin , Nurdin Riandi Adiputra 
Published: March 2022

The existence of fiduciary dispute resolution by way of execution that is not in accordance with statutory regulations. Based on this, the purpose of this study is to determine the debtor's responsibility and legal protection for creditors in a fiduciary guarantee agreement. The normative research method is the process of finding rules, principles and legal doctrines. As for the results of this research, the debtor's responsibility to transfer the object of fiduciary security, namely compensation in the form of restoration to its original state, compensation, criminal liability, the debtor can be sentenced to imprisonment of up to two years and a fine of protection against creditors is to provide definite terms to the creditor.

Adanya penyelesaian sengketa fidusia dengan cara eksekusi yang tidak sesuai dengan peraturan perundang-undangan. Berdasarkan hal tersebut, maka penelitian ini bertujuan mengetahui tanggung jawab debitur dan perlindungan hukum bagi kreditur pada suatu perjanjian jaminan fidusia. Metode penelitian normatif yaitu dengan proses menemukan aturan, prinsip, dan doktrin hukum. Hasil penelitian menunjukkan bahwa tanggung jawab debitur yang mengalihkan objek jaminan fidusia yaitu ganti rugi berupa pemulihan seperti keadaan semula, ganti kerugian, tanggung jawab secara pidana. Debitur dapat dipidana dengan pidana penjara paling lama dua tahun dan denda perlindungan terhadap kreditur dengan memberikan ketentuan yang pasti akan kreditur.
Manajemen Strategi Pengelolaan Taman Bacaan Masyarakat di Wadas Kelir
Authors: Jubaedah Dedah , Subur Subur 
Published: March 2022

Taman Bacaan Masyarakat (TBM) disediakan untuk memotivasi keminatan membaca bagi warga belajar dan masyarakat. Tujuan penelitian ini untuk mengetahui bagaimana manajemen strategi pengelolaan taman bacaan masyarakat di wadas kelir Kecamatan Purwokerto Selatan Kabupaten Banyumas. Jenis penelitian ini adalah field research atau penelitian lapangan dengan pendekatan kualitatif. Hasil penelitian mengungkapkan bahwa manajemen strategi pengelolaan mengacu pada tiga kategori yaitu, identifikasi strategi pengelolaan taman bacaan masyarakat, implementasi strategi pengelolaan taman bacaan masyarakatdan dampak strategi pengelolaan taman bacaan masyarakat. TBM Wades Kelir bergerak bersama warga masyarakat memprogram kegiatan peminjaman buku bacaan, ruang bacaan, ruang diskusi, sekolah literasi dan kegiatan sosial lainnya sehingga prestasi anak dan jenjang pendidikan bisa meningkat, dan banyak karya nyata.

Community Reading Park (TBM) is a place for community learning with facilities for borrowing and borrowing books equipped with a discussion room, writing and other literacy activities. TBM provides reading materials that have been provided to motivate reading interest for learning residents and the community. The purpose of this study was to find out how the management strategy of the Community Reading Park in Wadas Kelir, South Purwokerto District, Banyumas Regency was managed. This type of research is field research or field research with a qualitative approach because it describes events or phenomena that occur. Field data collection was carried out using observation, interview and documentation techniques. Meanwhile, data analysis was carried out through data reduction, data display and conclusion drawing. The results of the study revealed that management strategy management refers to three categories, namely, identification of community reading park management strategies, implementation of community reading park management strategies, and the impact of community reading park management strategies. TBM Wadas Kelir works with community members in breaking the education chain, namely by programming reading book lending activities, discussion rooms, literacy schools, and other social activities. As a result, childrens achievement increases, education levels increase, and there are many real works.
Kualitas Pelayanan Kader Posyandu Anggrek Lila di Kelurahan Labuh Baru Timur Kecamatan Payung Sekaki Kota Pekanbaru
Authors: Witsetiawati Nurni'ini Rizky , Wilson Wilson , Ayub Daeng 
Published: March 2022

Posyandu merupakan salah satu fasilitas yang diberikan pemerintah dalam bidang kesehatan sehingga masyarakat berharap adanya pelayanan yang mudah, cepat dan jelas. Penelitian ini bertujuan untuk mengetahui bagaimana kualitas pelayanan Kader Posyandu Anggrek Lila di Kelurahan Labuh Baru Timur Kecamatan Payung Sekaki Kota Pekanbaru. Penelitian ini merupakan jenis penelitian kuantitatif dengan pendekatan deskriptif, metode pengumpulan data yang digunakan adalah Simple Random Sampling. Hasil penelitian menunjukkan tingkat Kualitas Pelayanan Kader Posyandu Anggrek Lila di Kelurahan Labuh Timur Kecamatan Payung Sekaki Kota Pekanbaru sudah berjalan dengan baik akan tetapi masih ada beberapa pelayanan yang harus ditingkatkan.

The quality of service action in giving service that creates community satisfaction. The study was useful to find out the extent of the repair or service of the cadavers posyandu orchid Lila in the new east supplement of a new appendage section of the new Pekanbaru city. This study will be viewed by 5 indicators of (1) tangibility (physical evidence), (2) reliability (reliability), (3) responsiveness (responsiveness), (4) assurance (assurance), (5) trustworthiness. And it belongs to a quantitative class with a descriptive approach. The method of collecting data used is simple random sampling. Statistical and inferential data analysis techniques. Techniques make research decisions using mean and based on contribution. The research sample of 51 mothers under five. This study showed the quality of the staff posyandu anggrek Lilas service in the east end of Pekanbaru me five indicators of physical evidence, reliability, responsiveness, assurance, and empathy had worked only a few services to impress.
СУТНІСТЬ ТА КЛАСИФІКАЦІЯ МЕХАНІЗМІВ ПУБЛІЧНОГО УПРАВЛІННЯ ПРОТИДІЄЮ РЕЙДЕРСТВУ
Authors: Кузьменко Тетяна 
Published: March 2022

В Україні й надалі триває перерозподіл прав власності на засоби виробництва. Використовуються як цілком легальні (купівля-продаж, злиття-поглинання), так і протиправні способи, у тому числі рейдерство. Забезпечення захисту активів суб’єктів господарювання можливе за умови належного використання відповідних механізмів публічного управління протидією рейдерству. Проблематика публічного управління протидією рейдерству стала наріжним каменем ряду наукових публікацій і дисертаційних досліджень фахівців з державного управління, економіки, права тощо. Вихідною базою є дисертаційні дослідження й фахові публікації провідних науковців, які досліджували особливості методології публічного управління протидією рейдерства. Доповнення наявної методології галузі знань 28 «Публічне управління та адміністрування» передбачає: уточнення змістовних характеристик понять «протидія рейдерству» (процес, у межах якого уповноважені органи публічного управління здійснюють комплекс заходів, що спрямовані на захист інтересів власників і співробітників підприємств, й передбачають реагування на дії рейдерів задля попередження рейдерських атак, а у разі їх реалізації – на мінімізацію негативних наслідків) та «механізми публічного управління протидією рейдерству» (сукупність доступних методів і засобів управління, використовуючи які уповноважені органи публічного управління реагують на ймовірні та фактичні рейдерські атаки); вдосконалення класифікації таких механізмів залежно від рівня, суб’єкта, об’єкта, етапу, мети та способу впливу; конкретизовано перелік специфічних засобів (у межах традиційних методів) публічного управління протидією рейдерству. Подальші наукові розвідки мають бути присвячені розробці теоретичних положень і практичних рекомендацій, спрямованих на вдосконалення публічного управління протидією рейдерству.
PUBLIC PERCEPTION OF THE POTENTIAL OF WATERFALL TOURISM IN BENGKULU PROVINCE AFTER THE ENACTMENT OF THE NEW NORMAL COVID PANDEMIC 19
Authors: Nasution Suswati , Wagini  , Irwanto Tito 
Published: March 2022

The purpose of this study was to determine public perceptions about the tourism potential of the Waterfall in Bengkulu Province. By taking six waterfall tourism objects in three regencies namely North Bengkulu Regency, Bengkulu Tengah Regency and Kepahing Regency, each regency has two waterfall ojek tourism objects studied. , where the assessment of perceptions concerns the accessibility to the waterfall, infrastructure supporting the accessibility of the waterfall, security of the location of the waterfall, promotion and marketing, the organization managing the object of the waterfall, the presence or absence of community economic activities, the presence or absence of the tourism industry, and environmental comfort including protocols health deter covid pandemic 19. This type of research is a survey research with quantitative and qualitative analytical descriptive methods, where the questionnaire as the main tool for data collection, data analysis uses an average distribution with measurement of 5-point Likert scale and frequency distribution with the help of SPSS software .
The results showed that the public perception of the potential of the waterfalls studied at six locations of waterfalls that were examined were good. Based on the perception of the people studied, most respondents felt that the indicators were good, this certainly could be used as input for the local government in order to further improve the improvement indicators requested by the community. The results of this study can be used as a basis by decision makers in Bengkulu Province because most districts all have waterfall tourist destinations. This tourism potential cannot be ignored, especially in the New Normal Era, tourists prefer to be friends with nature.
Outcomes of Systemic Treatment in Children and Adults With Netherton Syndrome: A Systematic Review
Authors: Nouwen Anouk E. M. , Schappin Renske , Nguyen N. Tan , Ragamin Aviël , Bygum Anette , Bodemer Christine , Dalm Virgil A. S. H. , Pasmans Suzanne G. M. A. 
Published: March 2022

BackgroundComèl-Netherton syndrome (NS) is a rare disease caused by pathogenic variants in the SPINK5 gene, leading to severe skin barrier impairment and proinflammatory upregulation. Given the severity of the disease, treatment of NS is challenging. Current treatment regimens are mainly topical and supportive. Although novel systemic treatment options for NS have been suggested in recent literature, little is known about their outcomes.Objectiveto provide an overview of systemic treatment options and their outcomes in adults and children with NS.MethodsEmbase, MEDLINE, Web of Science, Cochrane Central Register of Controlled Trials, and Google Scholar were searched up to July 22, 2021. Empirical studies published in English language mentioning systemic treatment in NS were enrolled. Studies that did not define a treatment period or report at least one outcome were excluded. Methodological quality was evaluated by the Joanna Briggs Institute critical appraisal checklist for case reports or case series. Overall quality of evidence of the primary outcome, skin, was assessed by the GRADE approach.Results36 case series and case reports were included. The effects of 15 systemic therapies were described in 48 patients, of which 27 were children. Therapies included retinoids, prednisolone, cyclosporine, immunoglobulins, and biologicals. In retinoids both worsening (4/15 cases) and improvement (6/15 cases) of the skin was observed. Use of prednisolone and cyclosporine was only reported in one patient. Immunoglobulins (13/15 cases) and biologicals (18/21 cases) showed improvement of the skin. Certainty of evidence was rated as very low.ConclusionNS is a rare disease, which is reflected in the scarce literature on systemic treatment outcomes in children and adults with NS. Studies showed large heterogeneity in outcome measures. Adverse events were scarcely reported. Long-term outcomes were reported in a minority of cases. Nonetheless, a general beneficial effect of systemic treatment was found. Immunoglobulins and biologicals showed the most promising results and should be further explored. Future research should focus on determining a core outcome set and measurement instruments for NS to improve quality of research.Systematic Review Registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?RecordID=217933, PROSPERO (ID: 217933).
Effects of Tocilizumab on Adults With COVID-19 Pneumonia: A Meta-Analysis
Authors: Chen Chi-Chung , Yang Yu-Pei , Tsai Hsien-Lung , Tung Tao-Hsin 
Published: March 2022

BackgroundCoronavirus disease-2019 (COVID-19), a worldwide disaster, has already affected lots of people. Effective care and therapy are currently being evaluated in full swing.PurposeOur purpose was to investigate the effects of tocilizumab, an interleukin-6 receptor inhibitor, on treatment of adult patients with COVID-19 pneumonia.Data Sources, Study Selection, and Data ExtractionWe conducted a meta-analysis and searched for relevant studies on Pubmed, Embase, and the Cochrane Library without restrictions on language from inception until February 1, 2021. Fifteen studies were included for this meta-analysis. Two authors independently selected and screened these studies, assessed the quality of included studies, and extracted related information.ResultsFifteen studies were included in this meta-analysis. The main studies showed that tocilizumab was associated with lower mortality (risk ratio = 0.62, 95% confidence interval = 0.46–0.83; and hazard ratio = 0.61, 95% confidence interval = 0.51–0.72). Using tocilizumab might also affect biochemistry indicators (lowered C-reactive protein and ferritin, increased lymphocyte count).ConclusionThese current bodies of evidence could indicate that early use of tocilizumab was associated with lower mortality in adult patients with COVID-19. Early use of tocilizumab could reduce the mortality rate of adult patients with COVID-19 without obvious fatal side effects, which may be a treatment option in patients with COVID-19 pneumonia.Systematic Review RegistrationThe study protocol was registered on PROSPERO (ID:242811).
Association Between Lateralized Periodic Discharge Amplitude and Seizure on Continuous EEG Monitoring in Patients With Structural Brain Abnormality in Critical Illness
Authors: Fatima Safoora , Sun Mengzhen , Gjini Klevest , Struck Aaron F. 
Published: March 2022

ObjectiveTo investigate the association between lateralized periodic discharge (LPD) amplitude and seizure risk on an individual level in patients with structural brain abnormality.MethodsRetrospective case–control study of patients with structural brain abnormality undergoing continuous EEG monitoring was performed. We included 10 patients with LPDs and seizures as cases and 10 controls, patients with LPDs without seizure. Analysis was performed with a mixed-effects model with primary outcome measure of number of seizures per 8-h EEG epoch with fixed effects being variables of interest and random effect being subject ID.ResultsEpochs with seizures showed a higher absolute amplitude (corrected p = 0.04) and a higher relative amplitude (corrected p = 0.04) of LPDs. Additionally, the number of seizures was higher in epochs that had LPDs with plus features (uncorrected p = 0.002) and LPDs with higher relative amplitude (uncorrected p = 0.005).ConclusionHigher LPD amplitude is associated with increased risk of seizures on an individual patient level. A decreasing amplitude is suggestive of decreasing seizure risk, and may in fact be suggestive of decreasing ictal character of LPDs.
Association of High Dietary Acid Load With the Risk of Cancer: A Systematic Review and Meta-Analysis of Observational Studies
Authors: Keramati Majid , Kheirouri Sorayya , Musazadeh Vali , Alizadeh Mohammad 
Published: March 2022

ObjectiveThis study aimed to determine the relationship between the high dietary acid load (DAL) and the risk of cancer.MethodsFive databases of PubMed, Web of Sciences, Scopus, Cochrane Library, and Google Scholar was searched to elicit original studies on humans, up to June 2021. Quality of the articles, risk of bias, and heterogeneity were assessed. A random-effects meta-analysis model was applied to estimate pooled effect size with a 95% confidence interval. Sensitivity analysis was performed using a fixed-effects model. Subgroup analyses were carried out based on gender, age, type of cancer, and type of DAL assessment indicator.ResultsSeventeen effect sizes from 10 articles were included in the analysis. Overall, individuals with the highest DAL were associated with a 66% increased risk of cancer compared to those with the lowest DAL (p &lt; 0.001]. The risk of cancer increased 41% (p &lt; 0.001) and 53% (p = 0.03) by high PRAL and NEAP, respectively. High DAL was associated with 32% (p &lt; 0.001) and 79% (p &lt; 0.001) increased risk of breast and colorectal cancers, respectively. High DAL was associated with 32% (p = 0.001) and 76% (p = 0.007) increased risk of cancer incident in women and men, respectively. The risk of cancer incident increased 35% (p &lt; 0.001) and 49% (p &lt; 0.001) at age ≤ and &gt; of 50, respectively.ConclusionHigh DAL may be associated with a higher risk of cancer incidence not only in the whole studied population but also across cancer types, both genders, both DAL assessment indicators, and also among both high- and low-risk age groups for cancer.
Global Trends in Death, Years of Life Lost, and Years Lived With Disability Caused by Breast Cancer Attributable to Secondhand Smoke From 1990 to 2019
Authors: Ou Zejin , Gao Yunxia , Jiang Diwei , Cui Jiaxin , Ren Yixian , Tang Shihao , Duan Danping , Yu Danfeng , Wang Zhi 
Published: March 2022

BackgroundSecondhand smoke is an important risk factor to breast cancer patients’ survival. This article aimed to describe the epidemiological changes of health loss caused by female breast cancer attributable to secondhand smoke from 1990 to 2019.MethodsData on breast cancer was derived from the Global Burden of Disease study 2019. The epidemiological status and trends were estimated using the number, age-standardized rate (ASR), and estimated annual percentage change (EAPC).ResultsIn 2019, secondhand smoke-related breast cancer caused 168.33×102 death, 5242.58×102 years of life lost (YLLs), and 334.03×102 years lived with disability (YLDs) globally. The overall ASR of death and YLLs caused by breast cancer attributable to secondhand smoke presented decreasing trends from 1990 to 2019, with the respective EAPCs of −0.78 and −0.87. Meanwhile, decreasing trends occurred in most geographic regions, particularly that of YLLs in high-income North America (EAPC = −3.35). At the national level, most countries/territories had decreasing trends of death and YLLs, particularly Denmark, in which the respective EAPCs were −4.26 and −4.64. However, the ASR of YLDs showed an increasing trend globally (EAPC = 0.32). Meanwhile, increasing trends were observed in most regions and countries, particularly the Solomon Islands and Lesotho, with the respective EAPCs being 6.18 and 4.33. The changing trends were closely associated with sociodemographic development.ConclusionsTrends in secondhand smoke-related death and YLLs caused by breast cancer declined from 1990 to 2019. However, secondhand smoke remains a challenge to the patients’ longevity and quality of life. The findings informed strategies should be strengthened the control of secondhand smoking.
A Nomogram for Predicting Event-Free Survival in Childhood Acute Lymphoblastic Leukemia: A Multicenter Retrospective Study
Authors: He Yun-yan , Wu Xiao-jing , Zhou Dun-hua , Yang Li-hua , Mai Hui-rong , Wan Wu-qing , Luo Xue-qun , Zheng Min-cui , Zhang Jun-lin , Ye Zhong-lv , Chen Hui-qin , Chen Qi-wen , Long Xing-jiang , Sun Xiao-fei , Liu Ri-yang , Li Qiao-ru , Wu Bei-yan , Wang Li-na , Kong Xian-ling , Chen Guo-hua , Tang Xian-yan , Fang Jian-pei , Liao Ning 
Published: March 2022

ObjectiveEven though childhood acute lymphoblastic leukemia (ALL) has an encouraging survival rate in recent years, some patients are still at risk of relapse or even death. Therefore, we aimed to construct a nomogram to predict event-free survival (EFS) in patients with ALL.MethodChildren with newly diagnosed ALL between October 2016 and July 2021 from 18 hospitals participating in the South China children’s leukemia Group (SCCLG) were recruited and randomly classified into two subsets in a 7:3 ratio (training set, n=1187; validation set, n=506). Least absolute shrinkage and selection operator (LASSO) and multivariate Cox regression analysis were adopted to screen independent prognostic factors. Then, a nomogram can be build based on these prognostic factors to predict 1-, 2-, and 3-year EFS. Concordance index (C-index), area under the curve (AUC), calibration curve, and decision curve analysis (DCA) were used to evaluate the performance and clinical utility of nomogram.ResultThe parameters that predicted EFS were age at diagnosis, white blood cell at diagnosis, immunophenotype, ETV6-RUNX1/TEL-AML1 gene fusion, bone marrow remission at day 15, and minimal residual disease at day 15. The nomogram incorporated the six factors and provided C-index values of 0.811 [95% confidence interval (CI) = 0.792-0.830] and 0.797 (95% CI = 0.769-0.825) in the training and validation set, respectively. The calibration curve and AUC revealed that the nomogram had good ability to predict 1-, 2-, and 3-year EFS. DCA also indicated that our nomogram had good clinical utility. Kaplan–Meier analysis showed that EFS in the different risk groups stratified by the nomogram scores was significant differentiated.ConclusionThe nomogram for predicting EFS of children with ALL has good performance and clinical utility. The model could help clinical decision-making.
Case Report: Aumolertinib as Neoadjuvant Therapy for Patients With Unresectable Stage III Non-Small Cell Lung Cancer With Activated EGFR Mutation: Case Series
Authors: Feng Shao , Qiang Zhang , Wanwan Cheng , Zhaozhun Zeng , Yuewu Xie , Shencun Fang 
Published: March 2022

BackgroundThere is no standard treatment for stage III lung cancer due to its low surgical resection rate, and improving PFS and survival of patients with III NSCLC has become an urgent challenge in clinical treatment. For EGFR mutation-positive patients, targeted therapy has the remarkable feature of high efficiency and low toxicity compared with first-line standard chemotherapy, and targeted neoadjuvant therapy needs to be further explored.MethodWe report 3 diagnosed cases of locally advanced unresectable NSCLC with EGFR-sensitive mutations who first received 1–2 cycles of preoperative chemotherapy neoadjuvant therapy and were treated with 110 mg daily of 3rd-generation EGFR-TKI aumolertinib instead because of poor efficacy or safety intolerance.ResultAfter 2 cycles of aumolertinib treatment, all 3 patients achieved symptomatic remission and significant tumor size reduction and achieved downstaging to allow surgical treatment. No additional operative difficulties were added during the surgery. They continued to receive adjuvant therapy with the original dose of aumolertinib after surgical treatment, and no evidence of tumor recurrence was found until the most recent imaging examination. In addition, the course of neoadjuvant and adjuvant therapy was free of serious adverse effects.ConclusionPerioperative treatment of these three cases of locally advanced unresectable NSCLC with EGFR-sensitive mutations with the third-generation EGFR-TKI aumolertinib showed significant efficacy and excellent safety and may be a new option for targeted therapy in the perioperative period.