bluuebunny/crossref_metadata_2025_split huggingface dataset:
Au-delà du signifiant imaginaire : repenser l’inscription du fantasme au cinéma
Authors: Willis Louis-Paul 
Published: January 2022

Le rapport entre la théorie du cinéma et la psychanalyse demeure trouble, tant sur le plan conceptuel qu’épistémologique, et ce, depuis les toutes premières études psychanalytiques du cinéma. Ce rapport se trouve complexifié par des avancées distinctes dans les cercles savants francophones et anglophones. Voulant faire le pont entre les réflexions françaises et anglo-saxonnes, cet article se propose de relire les fondements de l’ouvrage Le signifiant imaginaire en articulant les enjeux soulevés par Christian Metz aux relectures lacaniennes offertes par des penseurs contemporains tels que Joan Copjec, Todd McGowan, Elizabeth Cowie et Slavoj Žižek – des penseurs qui prennent acte de certaines lacunes largement présentes dans la théorie des années 1970. Il en ressort une réflexion voulant repenser le régime de signification opérant au cinéma, puisqu’à l’époque de Metz, certains concepts lacaniens (le fantasme, le désir, l’objet a, le Réel) demeuraient absents des discours théoriques en études cinématographiques. Il s’agira donc de redéfinir le désir spectatoriel en l’articulant à une « réelle » pensée lacanienne, le tout afin de resituer la place du signifiant cinématographique en le liant au rôle du fantasme. De nature avant tout programmatique, cet article ne consolidera pas son propos par le biais d’analyses filmiques, mais s’attardera plutôt à des enjeux théoriques afin de plaider pour l’approche mise de l’avant par l’américain Todd McGowan dans l’ouvrage The Real Gaze. Si le fantasme joue un rôle central dans l’articulation du désir spectatoriel, il nous appartiendra de voir comment ce rôle se rapporte au regard, au Réel et au fameux signifiant cinématographique.
La jurisprudence de droit linguistique à la Cour suprême du Canada sous le règne Harper : comment expliquer le changement de paradigme?
Authors: Chouinard Stéphanie 
Published: January 2022

Cet article teste l’hypothèse à savoir si les décisions en matière de droit linguistique à la Cour suprême du Canada, moins généreuses envers les minorités linguistiques depuis le début des années 2000, sont liées à l’arrivée au pouvoir du gouvernement conservateur de Stephen Harper, gouvernement généralement plus réfractaire à une application libérale de laCharte canadienne des droits et libertés. Par l’entremise de l’analyse de trois variables, soit le soutien du gouvernement Harper envers les langues officielles, le pouvoir prédictif du parti politique sur l’idéologie des juges au Canada, et les nombreux revers du gouvernement Harper à la Cour suprême dans d’autres litiges touchant laCharte, l’article argumentera qu’on ne peut pas inférer une telle influence du gouvernement Harper sur les décisions de la CSC dans le domaine du droit linguistique.
Workload, workplace violence and harassment, and well-being of personal support workers in home and community care
Authors: Sayin Firat K. , Denton Margaret , Brookman Catherine , Davies Sharon , Zeytinoglu Isik U. 
Published: January 2022

Demand for home and community care services has continuously increased in Canada and elsewhere in the last few decades due to aging of the population and healthcare policy changes shaped by budgetary limitations. As a result, home and community care organizations are having trouble hiring adequate numbers of healthcare workers to meet the escalating demand, the result being increased workload on these workers. Another stream of literature has shown that care recipients and their family members, frustrated with the limited ability of healthcare workers to provide adequate care because of increased workload, might resort to violence and harassment. Bringing these two streams of literature together, we examined the relationships among three variables : workload ; workplace violence and harassment ; and well-being of personal support workers (PSWs).
Using structural equation modeling, we analyzed a 2015 Ontario-wide survey of 1,347 PSWs employed in the home and community care sector. The results indicate that workload is negatively associated with extrinsic and intrinsic job satisfaction, and this relationship is mediated by violence and harassment and by stress. Specifically, workload is positively associated with violence and harassment at work, which in turn is positively associated with stress, which in turn is negatively associated with extrinsic and intrinsic job satisfaction.
Our study contributes to the literature by examining the impact of a work environment factor, workload, on the well-being of PSWs. This approach makes it possible to expand the current literature’s focus on psychological processes at the individual level to a more contextual approach. Furthermore, the results have important implications for home and community care organizations as well as for the healthcare sector in general. The well-being of PSWs is critical to retaining them and to ensuring the quality of care they provide their clients. Thus, their workload should be lowered to a more manageable level to help minimize the violence and harassment they experience.
Biochemical profile in mixed martial arts athletes
Authors: Tota Łukasz Marcin , Wiecha Szczepan Stanisław 
Published: January 2022

The study aimed to evaluate changes in selected biochemical indicators among mixed martial arts competitors in subsequent periods of the training cycle. The research involved 12 mixed martial arts athletes aged 25.8 ± 4.2 years competing in the intermediate category. Selected somatic indicators were measured twice. Biochemical indicators were assessed five times during the 14-week study period. Serum concentrations of testosterone, cortisol, uric acid, myoglobin, total protein, interleukin 6, and tumor necrosis factor, as well as creatine kinase activity were determined. One hour after sparring completion, there were significant increases in cortisol (by 54.9%), uric acid (22.0%), myoglobin (565.0%), and interleukin 6 (280.3%) as compared with the values before the simulated fight. The highest creatine kinase activity (893.83 ± 139.31 U/l), as well as tumor necrosis factor (3.93 ± 0.71 pg/ml) and testosterone (5.83 ± 0.81 ng/ml) concentrations (p = 0.00) were recorded 24 hours after the simulation. Systematic observation of selected blood biochemical indicators in the training process periodization in mixed martial arts helps understand adaptive, compensatory, and regenerative mechanisms occurring in training athletes.
Medical cannabis use in Thailand after its legalization: a respondent-driven sample survey
Authors: Assanangkornchai Sawitri , Thaikla Kanittha , Talek Muhammadfahmee , Saingam Darika 
Published: January 2022

Background
Many countries now allow the consumption of cannabis or cannabinoids for medical purposes with varying approaches concerning products allowed and the regulatory frameworks prevailing their endowment. On 18 February 2019 Thailand passed legislation allowing the use of cannabis for medical purposes. This study aimed to examine patterns and purposes for consumption of medical cannabis, and consumers’ perceptions and opinions towards benefits and harms of cannabis and related policies in 2019–2020.

Methods
A cross-sectional study using a respondent-driven sampling (RDS) method was conducted in four sites across Thailand. Participants were 485 adults aged 18 years and over, living in the study region, who had used cannabis for medical purposes within the past 12 months. Face-to-face interviews using a structured questionnaire were used to collect data on (1) demographic characteristics, (2) pattern of consumption, (3) source of information and perception of benefits and harms of medical cannabis, and (4) opinion towards cannabis policies. Data were analyzed using RDS Analyst and presented as percentage and mean with 95% confidence interval (CI).

Results
Most participants (84.7%, 95% CI [78.9–90.5]) used an oral form of crude oil extract while 9.2% (95% CI [4.1–14.2]) used the raw form. The most common uses were for treatment of cancers (23.3%, 95% CI [16.1–30.4]), neuropsychiatric symptoms (22.8%, 95% CI [17.5–28.0]), and musculoskeletal pains (21.6%, 95% CI [16.7–26.6]). Illegal sources such as underground traders (54.5%, 95% CI [40.8–68.3]), friends and relatives (12.2%, 95% CI [6.2–18.3]), not-for-profit provider groups (5.2%, 95% CI [0.5–10.9]), and clandestine growers or producers (2.9%, 95% CI [0.6–5.3]) were the main suppliers. Most (>80%) perceived cannabis could treat cancers, chronic pains, insomnia, Parkinson’s disease and generalized anxiety disorder. Less than half perceived that cannabis could cause adverse conditions e.g., palpitation, panic, memory impairment and schizophrenic-like psychosis. Most respondents agreed or strongly agreed with the policies regarding permission to use cannabis for medical purposes (95.1%, 95% CI [92.0–98.2]), for the legal sale of medical cannabis products (95.9%, 95% CI [93.7–98.2]), and for people to grow cannabis for medical use (94.2%, 95% CI [91.8–96.5]). However, only two-thirds agreed with policies concerning the sales of cannabis (65.3%, 95% CI [56.9–73.7]) and home-grown cannabis for recreational purposes (61.3%, 95% CI [52.7–69.9]).

Conclusion
Our study reports the experiences of consumers of medical cannabis in the first year after its legalization in Thailand. Consumers reported various patterns and indications of consumption that were not supported by scientific evidence, but had positive perception of the results of consumption. These findings highlight ongoing policy challenges for Thailand and can be a lesson to be learned for other countries in the region.
Protective Effect of Ipomoea biloba on Myocardial Antioxidant Status in Isoproterenol Induced Myocardial Infarction Male Albino Rats
Authors: Vallipriya R. , Begum M. Shabana 
Published: January 2022

The protective effect of ethanolic leaf extract of Ipomoea biloba in isoproterenol (ISO)-induced cardiotoxicity and the antioxidant activity involved in this protection were investigated in rats. Myocardial infraction was produced in rats with 20 mg/kg b.wt of ISO administered subcutaneously twice at an interval of 24 h. Effect of EEIB oral treatment for 28 days at two doses (100 mg and 200 mg/kg body weight) was evaluated against ISO – induced cardiac necrosis. Level of enzymatic (SOD, CAT, GPx and GST), non-enzymatic (GSH, Vitamin C and E) and of membrane bound ATPases (Na+K+ATPase, Mg2+ATPase and Ca2+ATPase) were assayed in heart homogenate. Significant myocardial infarction, depletion of endogenous antioxidants enzymatic and non-enzymatic were observed in ISO-treated animals when compared with the normal animals. Rats induced with ISO, showed a significant (P<0.05), decrease in the activities of GSH, Vitamin C and Eon comparison with normal rats. EEIB elicited a significant cardioprotective activity by elevated the levels of GSH, SOD, CAT, GPx and GR. A significant decrease in the activity of Na+/K+ ATPase and a corresponding increase in the activities of Ca2+ ATPase and Mg2+ ATPase were observed in isoproterenol induced rats when compared to normal control rats. Pretreatment with EEIB was able to efficiently prevent the increase in activity of Mg2+ ATPase and maintain the activities of Na+ /K+ ATPase and Ca2+ ATPase at near normality. There is no significant difference between the control and plant alone treated rats. The aim of this investigation is to evaluate the antioxidant effects on the main cardioprotective activity of ethanolic leaf extract Ipomoea biloba.
Geoscience Assessment of Declined Production Rate and Recovery from a Reservoir in “ANDA” Field, Onshore Southwestern Niger Delta
Authors: I. E. Udoinyang, , Akpan Ekere, Udo , N. J. George, 
Published: January 2022

Declined production rates in wells producing from common reservoirs are enigmatic and generally viewed as phenomenal in some fields worldwide. The challenge posed by such discordant production trends forecloses the preponderance of totally and partially abandoned production, especially in aging fields. This study assesses possible factors associated with varying well production trends from a common reservoir in a field in the onshore western Niger Delta, by integrating multi-geoscience parameters including formation evaluation, 3D quantitative seismic analyses, paleoenvironmental diagnoses, paleobathymetric studies, and reservoir petrophysics to unravel the complexity of the reservoir. Composite well logs were collected from five wells selected for the study. Gamma-ray and SP logs were combined to delineate the depositional environment of "Heri sand" based on Schlumberger's (1985) log motif classification. The results were applied and found useful to develop an optimum recovery production plan for the study field. It has been revealed from this study that declined production performances of the Heri sand reservoir are attributed to the deposition of the reservoir in three distinct paleoenvironments under different bathymetric settings within a coeval period. These factors constitute strong influences on the petrophysics of the reservoir which invariably influences’ the production performance of the reservoir. Having realized the cause of the declined rate of the reservoir in the Anda field, the reservoir can be revitalized by well injection and fracturing.
Erectogenic Effect of Thyme (Thymus vulgaris) Extract in Normal and 5-Fluorouracil induced Oxidative Stressed Adult Male Wistar Rats
Authors: Akintemi O. Abimbola , Babalola R. O. , Babatunde S. O. 
Published: January 2022

This study determined the effect of oral administration of aqueous extract from Thyme (Thymus vulgaris) extract (TVE) on the antioxidant status and activity of some penile function enzymes (acetylcholinesterase (AChE), phosphodiesterase-5 (PDE-5), adenosine diaminase (ADA), and arginase) activity in normal and 5- Fluorouracil- induced oxidative stressed rats. Sixty adult Wister rats (210-225)g were divided into ten (10) groups (n=6): Group 1: received oral administration of normal saline (NC), Group 2: received 100 mg/kg of thyme extract orally (TE 100 mg/kg), Group 3: received 200 mg/kg of thyme extract orally (TE 200 mg/kg), rats in group four were treated with 400 mg/kg of thyme extract orally (TE 400 mg/kg), Those in group 5: received 25 mg/kg of Vitamin C orally, while group 6 to 10 were induced with 150 mg/kg of 5-Fluorouracil solution (5-FLU, i.p), but group 7-10 were treated 100 mg/kg, 200 mg/kg, 400 mg/kg and Vitamin C (25mg/kg), respectively. After fourteen (14) days of treatment, the rats were sacrificed and the penile tissue was carefully isolated and prepared into homogenate, which was used for antioxidant and enzymes biochemical analysis. The result revealed that i.p induction of 5-FLU caused a significant increase in malondialdehyde level, as well as AChE, ADA, PDE-5 and arginase activities wth concomitant decrease in thiol level when compared to control rats. However, the administration of TVE was found to reverse the effect of 5-FLU. The TVE was also found the reduced MDA level and all the enzyme activities, but boosted the thiol level in the normal rats when compared to control rats. Interestingly the effect of the TVE was found dose-dependently, and 400 mg/kg TVE was found to be more potent among all the doses used in both normal and 5-FLU-induced oxidative stress rats.
Awareness and Knowledge of the Adult Population in Saudi Arabia on Teeth Discoloration and Treatment Options: A Cross-Sectional Study
Authors: Alamassi Basil Y. , Alahmari Hatem S. , Alhabashy Mohammed S. , Talha Abdulrahman A. , Alfehaid Khalil W. , Alhuwaymil Abdulaziz A. 
Published: January 2022

Background: Tooth discoloration is a common condition. Discoloration can be a major aesthetic concern for some people and it can indicate pathology, so it needs to be addressed. The success of treatment of tooth discoloration is largely dependent on the knowledge and attitude of people towards it. Hence the aim of this cross-sectional questionnaire-based study was to evaluate knowledge and awareness of the adult Saudi population about the causes of tooth discoloration and its treatment options.
Materials and Methods: An online close-ended questionnaire consisting of 21 questions about tooth discoloration causes and treatment options were uploaded in Google Forms and was sent to 2000 adults in Saudi Arabia via email and social media websites. The questions were designed to evaluate patients’ knowledge about the various causes of tooth discoloration.
Results: A total of 1041 participants responded to our questionnaire. The study included 560 females (53.79%), and 448 participants aged between 18 and 24 years (43.04%), 192 (18.44%) between 25 and 35 years, 246 (23.63%) between 36 and 51 years, and 155 (14.89%) above 51 years. Most of the participants (n= 649; 62.34%) had a bachelor's degree. The most common answer to the type of teeth discoloration was internal and surface discoloration (n= 511; 49%). There was a positive response to the effect of diet, smoking, aging, and bacteria on tooth discoloration. 79% of the participants did not know what dental fluorosis is. The response to the effect of drugs on teeth discoloration split between "Yes" and "I don't know," and 688 of the participants (66.09%) did not know which drugs cause teeth discoloration. The personal effort was the most common way to obtain information about teeth discoloration (n= 678; 65.13%).
Conclusion: Within the limitations of this study, the level of knowledge about tooth discoloration was more concentrated on extrinsic factors, and the majority of the participants demonstrated poor knowledge about the intrinsic causes of tooth discoloration. The preferred treatment option of teeth discoloration was in office bleaching.
Desmoglein‐3 induces YAP phosphorylation and inactivation during collective migration of oral carcinoma cells
Authors: Ahmad Usama Sharif , Parkinson Eric Kenneth , Wan Hong 
Published: January 2022

Alterations of the Hippo–YAP pathway are potential targets for oral squamous cell carcinoma (OSCC) therapy, but heterogeneity in this pathway could be responsible for therapeutic resistance. We analysed the Hippo–YAP signatures in a cohort of characterised keratinocyte cell lines derived from the mouth floor and buccal mucosa from different stages of OSCC tumour progression and focused on the specific role of YAP on invasive and metastatic potential. We confirmed heterogeneity in the Hippo–YAP pathway in OSCC lines, including overexpression ofYAP1,WWTR1(often referred to as TAZ) and the major Hippo signalling components, as well as the variations in the genes encoding the intercellular anchoring junctional proteins, which could potentially regulate the Hippo pathway. Specifically, desmoglein‐3 (DSG3) exhibited a unique and mutually exclusive regulation of YAP via YAP phosphorylation during the collective migration of OSCC cells. Mechanistically, such regulation was associated with inhibition of phosphorylation of epidermal growth factor receptor (EGFR) (S695/Y1086) and its downstream effectors heat shock protein beta‐1 (Hsp27) (S78/S82) and transcription factor AP‐1 (c‐Jun) (S63), leading to YAP phosphorylation coupled with its cytoplasmic translocation and inactivation. Additionally, OSCC lines displayed distinct phenotypes of YAP dependency or a mixed YAP and TAZ dependency for cell migration and present distinct patterns in YAP abundance and activity, with the latter being associated with YAP nuclear localisation. In conclusion, this study provides evidence for a newly identified paradigm in the Hippo–YAP pathway and suggests a new regulation mechanism involved in the control of collective migration in OSCC cells.
Quantitatively evaluating activity and number of catalytic sites on metal oxide for ammonium perchlorate decomposition
Authors: Zhou Lin‐Yu , Cao Shao‐Bo , Zhang Liang‐Liang , Xiang Guolei , Zeng Xiao‐Fei , Chu Guang‐Wen , Chen Jian‐Feng 
Published: January 2022

AbstractAmmonium perchlorate (AP) catalytic thermal decomposition by metal oxides is complex and there is still no suitable quantitative evaluation method to characterize intrinsic catalytic activity. Here, a new method to quantitatively evaluate the catalytic capability of metal oxides for AP decomposition has been proposed. We introduce two indicators, intrinsic peak temperature () and catalytic density () in high‐temperature decomposition process, to uncouple activity and number of catalyst sites. Hematite (α‐Fe2O3) nanostructures with different shapes have been used as model catalysts to verify the feasibility of this method. Rod‐like α‐Fe2O3shows the best catalytic performance in AP decomposition with the lowest of 345.1°C and highest of 0.544, which indicate the largest number and highest activity of catalytic sites. Moreover, these new indicators are theoretically proven to be reasonable by density functional theory calculations.
One‐pot microwave‐assisted synthesis of dialkytin 2‐[(4‐methylbenzoyl) hydrazono]‐3‐phenylpropanoic acid complexes and their anticarcinoma activities and DNA‐binding properties
Authors: Jiang Wu‐Jiu , Tan Yu‐Xing , Peng Yi‐Yuan 
Published: January 2022

AbstractUnder microwave irradiation, five organotin complexes were produced through the reaction of 4‐methylbenzhydrazide, sodium phenylpyruvate and corresponding dialkyltin. Fourier transform infrared spectroscopy; 1H, 13C and 119Sn nuclear magnetic resonance spectroscopy; high‐resolution mass spectrometry; X‐ray crystallography and thermogravimetric analysis (TGA) were performed to characterise the synthesised complexes. The in vitro antitumour activity for the complexes involved was assessed using the MTT assay on the human carcinoma cells of HepG2, NCI‐H460 and MCF7. 2‐Oxo‐3‐pheny propionic acid p‐methyl benzoylhydrazone dibutyltin, C5, exhibited an intensive anticarcinoma activity. Cell apoptosis revealed that C5 mediated the cell apoptosis of HepG2 cells. DNA binding in C5 was investigated through UV‐visible absorption spectrometry and viscosity measurement. Molecular docking was performed for predicting C5‐DNA binding, which revealed C5 could be implanted into the DNA double helix.
Perspectives of online anatomy teachers: A neglected study population struggles with the invisible student
Authors: Attardi Stefanie M. , Mintz Noah M. , Rogers Kem A. 
Published: January 2022

AbstractOnline teachers are an under‐researched population, but their perspectives are crucial to the successful implementation of online education. A fully online section of an established face‐to‐face (F2F) two‐semester undergraduate anatomy course with a prosection laboratory commenced in 2012 at The University of Western Ontario, Canada. Professors' lectures for F2F students were broadcast in live and archived format to online students using Blackboard Collaborate (BBC) video conferencing software. Teaching assistants (TAs) delivered online laboratories using BBC and three‐dimensional (3D) anatomical computer models. This study explored the common experiences and issues faced by the course teachers from 2012 to 2014. Transcripts from open‐ended, individual interviews with professors (n = 4) and TAs (n = 5) were coded and analyzed thematically. The teachers' concern for their inability to see the students during sessions to assess class engagement and their teaching effectiveness, and to develop social relationships, was the main finding. However, video conferencing software and email were sufficient communication methods for the students' questions and the teachers' answers. The TAs noted usability challenges and anatomical inaccuracies in the 3D models compared to cadavers. Due to limitations of BBC's screen sharing function, live manipulation for the 3D computer models was not possible; however, the TAs found pedagogical value in using screen captures of the models for drawing activities with the students. Overall, preparation time for teaching online was longer than for F2F. The study's findings provide science educators with issues to consider when preparing for online teaching and recommendations to optimize the teaching experience.