bluuebunny/crossref_metadata_2025_split huggingface dataset:
Flow direction for analysis of the concentration of metals in the groundwater of the Western Amazon region (Ji-Paraná/RO), Brazil
Authors: Ramos Caryne Ferreira , Laureano Josilena de Jesus , Lopes Daise Silva , Sousa Lindolaine Machado , Lima Tiago Oliveira , Gomes Beatriz Machado , Júnior Walkimar Aleixo Costa , Bastos Wanderley Rodrigues , Oliveira Robson Alves , Nascimento Maria Cristina Nery do , Rosa Ana Lúcia Denardin da , Nascimento Elisabete Lourdes do 
Published: October 2022

Abstract
Metals refer to one of the main and most dangerous groups of water contaminants, so this research aimed to investigate the groundwater of Dois de Abril micro basin creek regarding the presence of metals and the spatial distribution of the elements regarding the underground flow direction. To that end,15 collections were performed in wells in February, March (High Waters – AA) and September 2019 (Low Waters – AB). The samples were analyzed for 14 inorganic chemicals by means of Inductively Coupled Plasma Optical Emission spectroscopy (ICP-OES). And through the Surfer 8.0 software, the flow direction was obtained using the potentiometric surface of the tubular wells registered in the Groundwater Information System - SIAGAS. Wilcoxon and Spearman tests were applied for the discussion of the results. The averages obtained are within the Maximum Allowed Values – MAV by the national human consumption legislation, but some wells presented high values for aluminum, iron, lead and barium, due to geochemistry and geology of the region, low pH values and the use and occupation of the soil. The trend of the underground flow direction of the municipality contributes to the main river that crosses the city. The flow direction and statistical tests applied were sufficient to discuss the results.
Rosmarinic acid as a novel biomedical drug for inhibiting the replication of herpes and dengue viruses: An In-silico assessment
Authors: Rani A. Christy , Kalaimathi K. , Jayasree S. , Murugesan S , S Prabhu , Cherian Pinkie 
Published: October 2022

Abstract
Since ancient times to till now, viruses such as dengue, herpes virus, ebola, AIDS, influenza, ebola, chicken meat and SARS have been roaming around causing great health burdens. To fight against these contagious viruses, people rely heavily on medicinal plants to enhance their immune system of innate and adaptive. In this research, the preparation of ligands and proteins was performed using the Maestro V.13.2 module tool. This software, consisting of LigPrep, Grid Generation, SiteMap and Glide XP, has each contributed significantly to the preparation of ligands and proteins. Ultimately, the research found that (R)-(+)-rosmarinic acid was found to have significant docking scores of -10.847 for herpes virus, of -10.033 for NS5 and − 7.259 for NS1. In addition, the Pass Server prediction indicates that rosmarinic acid possesses a diverse spectrum of enzymatic activities, as Probability Active (Pa) values ​​start at > 0.751; whereas it has fewer adverse effects than the drugs prescribed for viruses. Accordingly, it was found that the rate of acute toxicity values ​​of rosamric acid. According to this analysis, we expect that the current research will reveal a clear route to finding a medicine that can successfully lessen the complications of numerous viruses without causing any harmful effects. Ultimately, we concluded that (R)-(+)-rosmarinic acid would expose significant antiviral effects in in-vitro and in-vivo experiments and also this research would be a valuable asset for future especially those who wish to discover a drug molecule for variety of viruses.
Effect of RNAi-mediated survivin and Hypoxia-inducible factor 1α gene silencing on proliferation, invasion, migration and apoptosis of gastric cancer BGC-823 cells
Authors: Yupeng Li , Mingzhu Chang , Runhong Mu , Jianyu Zhu 
Published: October 2022

Abstract
Objective: To investigate the effect of RNAi-mediated survivin and Hypoxia-inducible factor 1α (HIF-1α) gene silencing on proliferation and apoptosis of gastric cancer BGC-823 cells.
Methods: Small interfering RNAs (siRNAs) targeting survivin and HIF1α mRNAs were designed and synthesized, respectively, while scrambled siRNAs (SCRs) were synthesized. The hypoxia sensitive gastric cancer line BGC-823 was identified and transfected by Hifectin II in vitro under hypoxia condition. The cells transfected with siRNA-survivin, siRNA-HIF-1α and SCR were named as sis group, siH group and SCR group, respectively.The expression of survivin and HIF-1α were assessed by RT-PCR and Western blotting assay respectively. Cell apoptosis were determined by flow cytometry. Cell proliferation was measured by MTT assay. The abilities of invasion and migration were evaluated by transwell assays and wound healing assays respectively.
Results: The HIF-1α expression of BGC-823 cells increased apparently under hypoxia condition. The survivin targeting siRNA transfection decreased the expression of survivin under hypoxia condition, the combined transfection of survivin targeting siRNA and HIF-1α targeting siRNA down-regulated both the expression of survivin and HIF-1α obviously. Compared with the blank control group, the combined siRNA transfection group displayed obvious features with decreased invasion and migration ability under hypoxia, the apoptosis rate increased and the cell proliferation decreased obviously.
Conclusion: The down-regulation of survivin and HIF-1α in BGC-823 cell lines may induce an anticancer effect by enhancing cell apoptosis, and decrease the proliferation, migration and invasion ability.
Can restless legs be a sign of something else? a case of spondyloarthritis presenting with restless legs syndrome
Authors: YILMAZ Ebru 
Published: October 2022

Abstract
Restless legs syndrome (RLS), is a chronic movement disorder, characterized by an urge or need to move the limbs, usually associated with uncomfortable sensations in the legs and sleep disorders. Two clinical forms of RLS are described in general: primary and secondary. Although primary RLS has a familial component, the underlying mechanism is still not fully understood but seems to be related to abnormalities in the dopaminergic pathways of the central nervous system. The secondary form of the syndrome is associated with iron deficiency, renal failure, pregnancy, diabetes mellitus, peripheral neuropathy, and many rheumatologic disorders such as rheumatoid arthritis (RA) and Sjögren’s syndrome. In a few clinical trials, an increased frequency of RLS has been reported in patients with spondyloarthritis. In this report, it is presented a case of coexistence spondyloarthritis and RLS showing satisfactory improvement with conservative treatment additionally adding naproxen. Anemia of chronic disease occurring in rheumatic diseases and associated iron deficiency may contribute to the development of RLS.
Regional Tracking problem for a reaction-diffusion equation with bilinear boundary controls
Authors: ElKabouss Abella , Zerrik EL Hassan 
Published: October 2022

Abstract
In this paper we investigate a regional optimal control problem of a reaction-diffusion equation evolving on a spatial domain Ω ⊂ R2 where controls act in bilinear manner on the boundary ∂Ω of Ω. It addresses the tracking of a desired state all over the time interval [0, T ] only on a subregion ω of Ω with minimum energy. This may be expressed as a minimization problem of which we discuss the existence and characterization of an optimal control. Then under a sufficient condition the uniqueness of such control is established. The obtained results lead to a computational algorithm that we illustrate by a two-dimensional fish diffusion model.
Circuit Quantum Electrodynamics with Dressed States of a Superconducting Artificial Atom
Authors: Kuo Watson , Chang Yu-Han , Dubyna Demetri , Chien Wei-Chen , Chen Chien-Han , Wu Cen-Shawn 
Published: October 2022

Abstract
A dynamical control of the coupling strengths between dressed states and probe photon states is demonstrated with a transmon-like artificial atom coupled to two closely spaced resonant modes. When the atom is driven with one mode, the atom state and driving photon states are superposed, forming the dressed states. Dressed states with 1st, 2nd and 3rd excited states of the atom were prepared and probed via the strong coupling to the other resonant mode. Spectroscopy reveals that the coupling strengths are ``dressed" and can be modulated by the power and sideband index of the driving. The transmission of the probe tone is modulated by the driving microwave amplitude with a Bessel behavior, displaying multi-photon process associated with the inter-atomic level transitions.
Pre-treatment Body Mass Index as a Predictive Biomarker for Immunotherapy Outcomes in Advanced Lung Cancer
Authors: Tong Gangling , Chen Boran , Li Chen , Zhang Linting , Wu Xuan , Yuan Wenqing , Liu Jinying , Wang Shubin , Li Shuluan 
Published: October 2022

Abstract
Objectives
To analyze the clinicopathological parameters of advanced lung cancer patients who received Immune checkpoint inhibitors (ICIs) treatment to establish pre-treatment body mass index (BMI) as a predictor of immunotherapy response, patient survival, and immune-related adverse events (irAEs).
Methods
We retrospectively evaluated a cohort of 92 patients who received therapy with ICIs for advanced lung cancer at our hospital between January 2018 and January 2021. Patients were categorized into three groups based on BMI; an underweight group (BMI < 18.5 kg/m2), a normal-weight group (18.5 kg/m2 ≤ BMI ≤ 24.9 kg/m2), and an overweight group (BMI ≥ 25 kg/m2). The correlations were observed between BMI and immunotherapy response, progression-free survival (PFS), and irAEs based on ICIs treatment.
Results
Pretreatment BMI levels were significantly associated with response to ICIs therapy in disease control rate (DCR) (p = 0.034) and PFS (p = 0.006) of patients with advanced lung cancer, and it was a non-significant trend towards objective response rate (ORR) (p = 0.086). Pretreatment BMI, gender, and PD-L1 expression level were independent prognostic factors for PFS in univariate and multivariate analyses: HR = 0.323, 95% CI: 0.141–0.737, p = 0.007, and HR = 0.277, 95% CI: 0.115–0.670, p = 0.004; gender: HR = 2.609, 95% CI: 1.198–5.683, p = 0.016; PD-L1: HR = 6.599, 95% CI: 1.555–27.996, p = 0.001). Higher BMI is a significant predictor for irAEs (p = 0 .016).
Conclusion
High pre-treatment BMI is associated with positive immunotherapy outcomes, while decreased BMI was associated with irAEs development.
Impact of Electricity Consumption on Manufacturing Output in Nigeria From 1980 – 2021
Authors: Quadri Salisu Temitope , Bukola Moronkeji Olamide 
Published: October 2022

Abstract
The study examine the impact of electricity consumption on manufacturing output in Nigeria of 1980 tо 2021. Different diagnostic test was carried out which include descriptive statistics, correlation, unit root test and Autoregressive Distributed Lag. Descriptive statistics was used to examine if the explanatory variables and the dependent variable exhibit time varying volatility and leptokurtosis characteristics. The АRDL bоunds tеstіng рrосеdurе revealed that in the long-run, labour, capital and electricity consumption are the only variables that determine manufacturing output in Nigeria but inflation and interest rate has negative insignificant effect on manufacturing output in Nigeria. Also in the short-run, the variables that determine manufacturing output are electricity consumption, labour, gross fixed capital formation and electricity production but electricity production has a negative significant effect on manufacturing output in Nigeria. The study therefore recommend that Government privatization policy of the electricity sub-sector should be highly monitored to provide enough electricity generation and consumption to encourage mass employment of a skilled and unskilled labour in the economy.
Critical Care Nurses Perceptions of Learning on E-Learning Platform in Medical College Hospital
Authors: Souza Bryal D' , Silva Helen Esther D' , Bhaskar Laxmi , Kumar Naveen 
Published: October 2022

Abstract
Aim
To study the perceptions of critical care nurses in using digital learning material in a multi-speciality hospital in India, with objectives to fulfil the primary objective as converting the classroom teaching modules into digital format and secondary objective was to identify the research gap of understanding the effectiveness of technology based (e-tools) tools for Continuous Nursing Education compared to Traditional classroom training.
Methodology:
Experimental, Case Control method study was done among nursing manpower from the Intensive care units of a multi-speciality tertiary care teaching hospital with 220 Intensive care beds. Non-Probability convenience sampling was taken with 335 nurses as experimental group and 335 participants who chose to attend the traditional training class formed the control group. A single training program was instituted on blood transfusion practices.
Results
It is seen that in the control group, the percentage increase in median scores was 11.8%, whereas experimental group had median score of 17.7%. The maximum improvement in at least one participant in the control group was 31.5% while in the experimental group it was 36.5%.
Conclusion
Digital educational technologies are vastly been embraced in nursing education. The digital platforms provide great amount of independence to the learner, utility of theoretical knowledge can be improved through virtual learning environments. This study reinforces the introductory experiences that our nursing personnel had, which prompts the administration to reduce the training costs.
Effect of surgeon case volume on major surgical complications for abdominal and laparoscopic radical hysterectomy for cervical cancer in China, 2004-2016: A retrospective cohort study
Authors: Liang Cong , Li Weili , Liu Xiaoyun , Zhao Hongwei , Yin Lu , Li Mingwei , Guo Yu , Lang Jinghe , Bin Xiaonong , Liu Ping , Chen Chunlin 
Published: October 2022

Abstract
Background
To date, there are few studies that have investigated the association between surgeon volume and outcomes of radical hysterectomy. To examine changes in surgeon volume over time and evaluate the influence of surgeon volume on complications of abdominal and laparoscopic radical hysterectomy for cervical cancer.
Methods
We conducted a population-based retrospective study using the Major Surgical Complications of Cervical Cancer in China (MSCCCC) database to collect the data of patients who underwent radical hysterectomy from 2004–2016 at 42 hospitals. Patients were stratified into tertiles according to annualized surgeon volume. The influence of the surgeon volume of abdominal and laparoscopic radical hysterectomy on surgical complications was examined using multivariable logistic regression models.
Results
A total of 22,684 patients who underwent radical hysterectomy were identified. In the abdominal surgery cohort, the mean surgeon case volume increased from 3.5 cases in 2004 to 8.7 cases in 2013 and then decreased to 4.9 cases in 2016. The number of surgeons performing laparoscopic radical hysterectomy increased from 1 surgeon with 1 patient (mean cases = 1) in 2004 to 183 surgeons who operated on 2,206 patients in 2016 (mean cases = 12.1) (P < 0.01). In the abdominal surgery cohort, patients treated by intermediate-volume surgeons had more postoperative complications (OR = 1.55, 95% CI = 1.11–2.15). In the laparoscopic surgery cohort, surgeon volume had no independent effect on intraoperative or postoperative complications (P = 0.46; P = 0.13).
Conclusions
The performance of ARH by intermediate-volume surgeons is associated with an increased risk of postoperative complications. However, surgeon volume may have little effect on intraoperative or postoperative complications after LRH.
Meta-path Discovering based Recommendation Model via Heterogeneous Graph Neural Networks
Authors: Sastry Sandhini , Goh Shankar , Leung Kristine , Fischer Michelle 
Published: October 2022

Abstract
In the era of information explosion, information overload has become a challenge for people to find information that interests them. Recommendation systems, as a kind of information filtering system, can understand users’ interests based on their personal data or historical behavior records, and are widely used in Web applications such as e-commerce, search, and streaming websites. However, traditional GNN-based recommendation algorithms can only handle regular topological graphs composed of a single type of nodes, while the data in today’s network is not composed of only a single type of nodes. In addition, traditional GNNs only fuse the first-order neighborhood features of nodes and cannot obtain the deeper structural relationships of nodes in the network. Therefore, when the data set is sparse and each node has only a very small number of neighbors, the recommendation quality of the traditional GNNbased recommendation algorithm decreases significantly. Heterogeneous graph neural networks provide new directions and ideas for recommendation research, and bring new challenges to data mining methods of heterogeneous graphs. Although the recommendation algorithm based on heterogeneous graph neural network is mainly based on the similarity of meta-paths, this method cannot effectively extract and utilize the rich structural and semantic information in heterogeneous graphs for recommendation, although the performance of the recommendation model can be improved by using the similarity of meta-paths. We proposed a joint multi-feature representation of information in heterogeneous information networks. For both user/item interaction and user socialization domains, the representation of node features in the case of sparse network connectivity is enhanced by using multi-order topological structure information in heterogeneous information networks. A graph neural network recommendation method oriented to attention mechanism is proposed. The recommendation quality of the recommendation model is enhanced in the case of sparse scoring matrix through the effective fusion of multidimensional representation vectors of users, items, ratings, and social. By conducting experiments on multiple public data sets, it is verified that the recommendation performance of our model in this paper significantly better than the baseline methods.
Inhibitors of Ras-Transformation
Authors: Sugita Kenji , Ohtani Mitsuaki 
Published: October 2022

Abstract:
Ras-oncogene is now thought to be one of the most important oncogenes which is evidenced in the correlation with human cancers. Point mutation in ras-gene correlates with transformation caused by ras and is found in human cancers with high frequency, such as 90% in pancreatic cancer, 50% in colon cancer and 30% in lung cancer. Ras (product of ms-oncogene) has GTPase activity and loses its activity with point mutation, leading to transformation. Active GTP-binding form of Ras is a key molecule of signal transduction in cell growth, differentiation and transformation.
Inhibitors of ms-transformation will be good candidates of anti-cancer agents. Although many inhibitors of ras­ transformation have been reported up to now including macromolecules (genes, nucleotides, antibodies), we summarize the small-molecule compounds, which inhibit ms-transformation in direct or indirect manner in this review. Direct inhibitors of ras include inhibitors of farnesylation of Ras. Farnesyltransferase inhibitors (L- 744,832, etc) include peptidomimetics with the rational drug design for C-terminus of Ras and natural products. Inhibitors of 3-hydroxy-3-methyl-glutaryl coenzyme A (HMG-CoA) reductase (Lovastatin, etc) which block cholesterol metabolism, inhibit farnesylation of Ras by decreasing the amount of the substrate of farnesyltransferase (Frase). Indirect inhibitors of ras with known mechanisms include the inhibitor of inositol monophosphate (IMP) dehydrogenase (oxanosine), the inhibitor of mitogen-activated protein kinase kinase (MAPK kinase)(PD98059), the inhibitor of MAPK (apigenin), the inhibitors of protein kinase C (PKC) (UCN- 01, etc), the inhibitors of phosphatidylinositol 3-kinase (Pl3K) (Wortmannin and L-294002), the inducer of the transcription factor JunD (oxamflatin) and the inhibitors of histone deacetylase [trichostatin A (TSA) and trapoxins]. Almost all compounds are now under development, and will be evaluated in clinical studies as anticancer agents.
Asthma Severity and Mental Well-being Among Children with Asthma in Kosovo
Authors: Beqaj Zhjeqi Valbona , Kundi Michael , Neziri Ahmetaj Luljeta , Shahini Mimoza , Ahmetaj Halil , Krasniqi Shaip 
Published: October 2022

Background:
Bronchial asthma is a chronic disease recognized as an important public health issue worldwide, causing a major global health burden. Due to its complex nature and varying characteristics, asthma has been a great challenge for public health.

Objective:
This article aims to determine the relationship between asthma severity and mental well-being among children with asthma in Kosovo.

Methods:
In a cross-sectional study conducted in 13 hospitals and outpatient clinics covering all areas of Kosovo, children with asthma aged 7 to 16 years were enrolled. Children and parents answered a questionnaire about socio-demographic characteristics and the Children Strengths and Difficulties Questionnaire (SDQ). Asthma severity was assessed according to the GINA (Global Initiative for Asthma) guidelines and categorized into two levels (IMPA, intermittent and mild persistent asthma; MSPA, moderate and severe persistent asthma).

Results:
Overall, 161 children with asthma and their caregivers were included. Strengths and difficulties questionnaire showed borderline or abnormal scores in about ¼ of children. A comparison of asthma severity groups for the different scales of the SDQ showed a statistically significant increase in emotional problems (p=0.009).

Conclusion:
Diminished mental health and emotional problems are relevant in children with a more severe course of the disease and should be taken into account in counseling parents and patients.
Nutritional Value of Lunches Served in The Remote Rural Area Child-Care Centers in Chiang Mai, Thailand
Authors: Wungrath Jukkrit , Yutabootr Sidapan , Limvilai Takdanai , Kapheak Krissana 
Published: October 2022

Introduction:
Child-care centers (CCCs) typically offer lunch to preschool children. The nutritional composition of lunches served in remote rural area CCCs was compared with 40% of the recommended Thai dietary reference intake (DRI) for children aged 3 to 5 years.

Methods:
Nine CCCs in Chiang Dow district, Chiang Mai Province, Thailand, were selected for the study. Lunch content was evaluated by weighing each food item served to children on two consecutive days. Nutrients were determined by the INMUCAL nutritional analysis software version 3.0. Average nutrient content of the lunches was compared with 40% of the recommended Thai DRI using a one-sample t-test.

Results:
Average nutrients in lunches served in CCCs in Chiang Dow district, Chiang Mai Province, did not meet 40% of the daily DRI nutritional recommendations. The lunches were statistically deficient in energy, protein, carbohydrate, fat, dietary fiber, iron, vitamin B1 and calcium. The cholesterol content was significantly higher than the daily DRI recommendations, while vitamin A, vitamin B2, vitamin C and iron contents were comparable with DRI recommended levels (p<0.05).

Conclusion:
CCC lunches in remote rural areas did not meet 40% of the daily Thai DRI nutritional recommendations. Lunch menus served in CCCs must be improved to provide appropriate nutrients and ensure the healthy growth and development of preschool children.