bluuebunny/crossref_metadata_2025_split huggingface dataset:
LIAISON® Calprotectin for the prediction of relapse in quiescent ulcerative colitis: The EuReCa study
Authors: Fiorino Gionata , Danese Silvio , Peyrin‐Biroulet Laurent , Sans Miquel , Bonelli Fabrizio , Calleri Mariella , Zierold Claudia , Pollastro Roberta , Moretti Fabio , Malesci Alberto 
Published: July 2022

AbstractIntroductionFecal calprotectin (FC) is established as a diagnostic marker to differentiate between inflammatory bowel diseases and non‐inflammatory conditions. Furthermore, it may be effective in monitoring response to treatment, and to predict relapse during maintenance therapy.DesignThis was a prospective longitudinal study carried out in Italy, France and Spain. The primary objective was to correlate the LIAISON® Calprotectin assay measurements to quiescent ulcerative colitis (UC) or relapse as assessed by clinical data. Patients were assessed every 3 months for 12 months, and at 18 months.ResultsThe last FC measured prior to relapse was the variable that predicted relapse in a statistically significant manner. With a 62.3 μg/g cut‐off the area under the curve was 0.619, and the sensitivity was 62.9% (95% Confidence Interval [CI] 44.9%–78.5%) and specificity 63.0% (95% CI 53.1%–72.1%). Using machine learning methods, the last FC measurement was shown to have the largest impact in predicting relapse. An algorithm was developed that included other variables available following a clinician's visit, which resulted in an area under the curve of 0.754 for predicting relapse.ConclusionIn the present study FC measured by the LIAISON® Calprotectin assay on the visit before relapse is predictive of relapse in patients with quiescent UC. In a proof of concept, the accuracy of prediction can further be improved including other variables in an algorithm developed by machine learning.Trial registrationThe trial is registered at clinicaltrials.gov with reference number NCT05168917.
Efficacy of high‐throughput transthoracic ultrasonographic screening for on‐farm detection of ovine pulmonary adenocarcinoma
Authors: Cousens Chris , Ewing David A. , McKendrick Iain J. , Todd Helen , Dagleish Mark P. , Scott Philip R. 
Published: July 2022

AbstractBackgroundThe aim of this study was to evaluate the efficacy of high‐throughput on‐farm transthoracic ultrasound (TUS) to screen for ovine pulmonary adenocarcinoma (OPA), an infectious ovine disease of increasing concern. No other routine diagnosis of preclinical OPA is available, or any vaccine or treatment.MethodsMore than 80,000 rapid TUS scans were applied on farms with a history of OPA. The TUS results from a convenience sample of 171 TUS‐negative and 269 TUS‐positive sheep were compared with postmortem histology/immunohistochemistry results, the ‘gold standard’ reference test for OPA diagnosis. These results, together with new data on within‐flock prevalence, allowed estimation of the efficacy of rapid TUS screening to identify OPA (defined as tumours of larger than 1 cm) on‐farm.ResultsThe TUS screening had an estimated specificity of 0.998 (95% confidence interval [CI]: 0.998–0.999) and an estimated sensitivity of between 0.76 (95% CI: 0.72–0.79) and 0.99 (95% CI: 0.97–0.99) depending on the presumed false‐negative rate applied to the calculation.ConclusionHigh‐throughput TUS should be considered for screening to identify individual sheep with OPA and has potential application to indicate flocks at low risk of OPA. However, lower efficacy is likely if conducted by less experienced persons.
Inadvertent endotracheal tube cuff rupture during unilateral arytenoid lateralisation for laryngeal paralysis in a dog
Authors: Daly Erica , Pratschke Kathryn , Lord Samuel 
Published: July 2022

AbstractA 12‐year 11‐month‐old, 8.3 kg Jack Russell terrier presented following three episodes of respiratory distress. On initial presentation, conservative management was successful; however, the dog re‐presented 10 weeks later with identical clinical signs. On the second presentation, investigations were unremarkable, so conservative management was continued. On discharge, the dog collapsed, following which, it was referred to the emergency and critical care department, within the same hospital. Examination under a light plane of general anaesthesia revealed left‐sided laryngeal paralysis; therefore surgical management was indicated. During cricoarytenoid laryngoplasty suture placement, a leak was noted in the circle breathing system based on alteration of the capnograph trace, collapse of the ventilator bellows, and noise on inspiration. The pilot balloon of the endotracheal tube had deflated, necessitating re‐intubation with a new endotracheal tube; a urinary catheter was used as a guidewire to facilitate this. The leak was abolished, and the procedure was completed successfully.
RE:LEAN – das Planspiel zu Lean Production
Authors: Flad Nadja , Bertagnolli Frank 
Published: July 2022

ZusammenfassungDas Planspiel RE:LEAN vermittelt den Spielern grundlegende wie auch innovative Lean-Prinzipien und -Methoden im Bereich Lean Production, welche diese direkt im Spiel auch anzuwenden lernen (Abb. 6.1). In drei aktiven Runden können die Spieler im Team vorhandene Verschwendungen aufdecken und gemeinsam geeignete Verbesserungsmaßnahmen entwickeln und umsetzen. Dabei lernen sie auch den Zusammenhang von ökologischen und ökonomischen Einsparpotenzialen kennen. Im Rahmen von Impulsvorträgen zum Thema Lean Production werden die unterschiedlichen Wissensstände innerhalb der Gruppe ausgeglichen und erweitert. Durch die interaktive Gestaltung des Spiels werden zudem die Sozialkompetenzen gefördert. Im Zuge einer ausführlichen Transferrunde am Ende werden die Spieler darin unterstützt, ihr neu erlerntes Wissen auf konkrete Fragestellungen in ihrem Unternehmensalltag zu übertragen. Das Planspiel kann grundsätzlich in allen Branchen angewandt werden, eignet sich aber besonders gut für Unternehmen mit einer Fertigung und Montage wie beispielsweise einer Serienproduktion.
Upper bound of the charge diffusion constant in holography
Authors: Huh Kyoung-Bum , Jeong Hyun-Sik , Kim Keun-Young , Sun Ya-Wen 
Published: July 2022

Abstract
We investigate the upper bound of charge diffusion constant in holography. For this purpose, we apply the conjectured upper bound proposal related to the equilibration scales (ωeq, keq) to the Einstein-Maxwell-Axion model. (ωeq, keq) is defined as the collision point between the diffusive hydrodynamic mode and the first non-hydrodynamic mode, giving rise to the upper bound of the diffusion constant D at low temperature T as $$ D={\omega}_{\mathrm{eq}}/{k}_{\mathrm{eq}}^2 $$
D
=

ω
eq

/

k
eq
2

. We show that the upper bound proposal also works for the charge diffusion and (ωeq, keq), at low T, is determined by D and the scaling dimension ∆(0) of an infra-red operator as $$ \left({\omega}_{\mathrm{eq}},{k}_{\mathrm{eq}}^2\right)=\left(2\pi T\Delta (0),{\omega}_{\mathrm{eq}}/D\right) $$

ω
eq

k
eq
2

=

2
πT
Δ

0

ω
eq

/
D

, as for other diffusion constants. However, for the charge diffusion, we find that the collision occurs at real keq, while it is complex for other diffusions. In order to examine the universality of the conjectured upper bound, we also introduce a higher derivative coupling to the Einstein-Maxwell-Axion model. This coupling is particularly interesting since it leads to the violation of the lower bound of the charge diffusion constant so the correction may also have effects on the upper bound of the charge diffusion. We find that the higher derivative coupling does not affect the upper bound so that the conjectured upper bound would not be easily violated.
Reconciling the contour-improved and fixed-order approaches for τ hadronic spectral moments. Part I. Renormalon-free gluon condensate scheme
Authors: Benitez-Rathgeb Miguel A. , Boito Diogo , Hoang André H. , Jamin Matthias 
Published: July 2022

Abstract
We propose a simple and easy-to-implement scheme for a renormalon-free gluon condensate (GC) matrix element, which is analogous to implementations of short-distance heavy-quark mass renormalization schemes existing in the literature already for a long time. Because the scheme is based on a perturbative subtraction at the level of the matrix element, with a freely adaptable infrared factorization scale, it can be implemented with little effort for any observable where the GC is relevant. The scheme depends on the renormalon norm of the GC which has to be supplemented independently. We apply the scheme to the fixed-order (FOPT) and contour-improved (CIPT) perturbative expansions of τ hadronic spectral function moments. These expansions exhibit a long-standing discrepancy for moments used in high-precision determinations of the strong coupling in the commonly used GC scheme that is not renormalon-free. We show that the scheme is capable of resolving the FOPT-CIPT discrepancy problem. At the same time, the perturbative behaviour of the moments that previously showed bad convergence properties and for which the non-perturbative corrections from the GC are sizeable, is substantially improved. The new GC scheme may provide a powerful theoretical tool for future phenomenological applications.
Fermions in AdS and Gross-Neveu BCFT
Authors: Giombi Simone , Helfenberger Elizabeth , Khanchandani Himanshu 
Published: July 2022

Abstract
We study the boundary critical behavior of conformal field theories of interacting fermions in the Gross-Neveu universality class. By a Weyl transformation, the problem can be studied by placing the CFT in an anti de Sitter space background. After reviewing some aspects of free fermion theories in AdS, we use both large N methods and the epsilon expansion near 2 and 4 dimensions to study the conformal boundary conditions in the Gross-Neveu CFT. At large N and general dimension d, we find three distinct boundary conformal phases. Near four dimensions, where the CFT is described by the Wilson-Fisher fixed point of the Gross-Neveu-Yukawa model, two of these phases correspond respectively to the choice of Neumann or Dirichlet boundary condition on the scalar field, while the third one corresponds to the case where the bulk scalar field acquires a classical expectation value. One may flow between these boundary critical points by suitable relevant boundary deformations. We compute the AdS free energy on each of them, and verify that its value is consistent with the boundary version of the F-theorem. We also compute some of the BCFT observables in these theories, including bulk two-point functions of scalar and fermions, and four-point functions of boundary fermions.
Breeding for disease resistance in soybean: a global perspective
Authors: Lin Feng , Chhapekar Sushil Satish , Vieira Caio Canella , Da Silva Marcos Paulo , Rojas Alejandro , Lee Dongho , Liu Nianxi , Pardo Esteban Mariano , Lee Yi-Chen , Dong Zhimin , Pinheiro Jose Baldin , Ploper Leonardo Daniel , Rupe John , Chen Pengyin , Wang Dechun , Nguyen Henry T. 
Published: July 2022

Abstract
Key message
This review provides a comprehensive atlas of QTLs, genes, and alleles conferring resistance to 28 important diseases in all major soybean production regions in the world.

Abstract
Breeding disease-resistant soybean [Glycine max (L.) Merr.] varieties is a common goal for soybean breeding programs to ensure the sustainability and growth of soybean production worldwide. However, due to global climate change, soybean breeders are facing strong challenges to defeat diseases. Marker-assisted selection and genomic selection have been demonstrated to be successful methods in quickly integrating vertical resistance or horizontal resistance into improved soybean varieties, where vertical resistance refers to R genes and major effect QTLs, and horizontal resistance is a combination of major and minor effect genes or QTLs. This review summarized more than 800 resistant loci/alleles and their tightly linked markers for 28 soybean diseases worldwide, caused by nematodes, oomycetes, fungi, bacteria, and viruses. The major breakthroughs in the discovery of disease resistance gene atlas of soybean were also emphasized which include: (1) identification and characterization of vertical resistance genes reside rhg1 and Rhg4 for soybean cyst nematode, and exploration of the underlying regulation mechanisms through copy number variation and (2) map-based cloning and characterization of Rps11 conferring resistance to 80% isolates of Phytophthora sojae across the USA. In this review, we also highlight the validated QTLs in overlapping genomic regions from at least two studies and applied a consistent naming nomenclature for these QTLs. Our review provides a comprehensive summary of important resistant genes/QTLs and can be used as a toolbox for soybean improvement. Finally, the summarized genetic knowledge sheds light on future directions of accelerated soybean breeding and translational genomics studies.
On the eigenvalues associated with the limit null distribution of the Epps-Pulley test of normality
Authors: Ebner Bruno , Henze Norbert 
Published: July 2022

AbstractThe Shapiro–Wilk test (SW) and the Anderson–Darling test (AD) turned out to be strong procedures for testing for normality. They are joined by a class of tests for normality proposed by Epps and Pulley that, in contrast to SW and AD, have been extended by Baringhaus and Henze to yield easy-to-use affine invariant and universally consistent tests for normality in any dimension. The limit null distribution of the Epps–Pulley test involves a sequences of eigenvalues of a certain integral operator induced by the covariance kernel of a Gaussian process. We solve the associated integral equation and present the corresponding eigenvalues.
Olfactory imagery as a retrieval method for autobiographical memories
Authors: Schlintl Carina , Zorjan Saša , Schienle Anne 
Published: July 2022

Abstract
Introduction
The retrieval of autobiographical memories is influenced by several factors, such as sensory modality and the emotional salience of memory cues. This study aimed at investigating the interaction between sensory modalities (olfaction, vision) and emotional dimensions (valence, arousal) of imagery cues, on the frequency, quality, and age distribution of the autobiographical memories (AMs) elicited.

Method
A total of 296 females (aged between 18 and 35 years) received one out of eight brief instructions for olfactory or visual imagery. The participants were asked to create a mental image with either high arousal/positive valence, high arousal/negative valence, low arousal/positive valence, or low arousal/negative valence (e.g., ‘imagine an unpleasant and arousing odor/scene’); no specific stimulus was mentioned in the instruction.

Results
The approach used elicited imagery with autobiographical content in the majority of participants (78%). In terms of frequency, odor imagery, compared to visual imagery, turned out to be more effective at retrieving either unpleasant memories associated with experiences in adulthood, or pleasant childhood memories. In terms of quality, the imagery was rated as less vivid in the olfactory compared to the visual condition (irrespective of valence and arousal of the imagery instruction). Visual imagery was associated with the experience of more diverse emotions (happiness, sadness, anxiety, anger) than odor imagery, which was related primarily with disgust and happiness.

Conclusion
Our findings indicate that nonspecific imagery induction is a useful approach in accessing AM.

Implication
This approach presents promising clinical applications, such as in working with autobiographical memory narratives in psychotherapy.
Stollenspeicher für Ausleitungskraftwerke
Authors: Richter Wolfgang , Zenz Gerald 
Published: July 2022

ZusammenfassungEine hydraulische Optimierung von Ausleitungskraftwerken mit Triebwasserstollen bietet sowohl wirtschaftliche, als auch ökologische Vorteile hinsichtlich Schwall-Sunk-Ausgleich, durch Auslegung als Speicherstollen mit differentiellen Wasserschlössern. Dies erhöht die Flexibilität und ermöglicht die Speicherbewirtschaftung des Triebwasserstollens.
Die Kosten der Niedrigzinspolitik am Wohnungsmarkt. Immobilienpreisblasen in B-Lagen am Beispiel Salzburg
Authors: Van-Hametner Andreas 
Published: July 2022

ZusammenfassungIn großen Teilen Europas, so auch in Deutschland und Österreich, boomt die Immobiliennachfrage. Immer häufiger wird Wohnraum aber nicht zum Wohnen, sondern als Anlage erworben. Neben institutionellen InvestorInnen kaufen zunehmend auch private AnlegerInnen, vor allem auf exponierten Märkten, die bislang schon einen Nachfrageüberhang aufwiesen. Wesentlich dazu beigetragen hat die Nullzinspolitik der EZB. Der Boom führt in vielen Städten zu Immobilienpreisblasen. Um das gestiegene Blasenrisiko abseits der Metropolen aufzeigen zu können, verwende ich am Beispiel der Stadt Salzburg ein Set aus vier Indikatoren: Die Leistbarkeit von Wohneigentum, die Rentabilität von Vermietungen, die Entwicklung der Fertigstellungen von Wohneinheiten sowie die Entwicklung der Wohnungsbaukredite. Mit diesen Indikatoren können regionale PlanerInnen und Politik Marktentwicklungen einschätzen und Preisblasen identifizieren. Sie zeigen für das Beispiel Salzburg eine deutliche regionale Überhitzung, welche auch durch die COVID-19-Pandemie nicht gestoppt wurde. Im Gegenteil haben die davon beeinflussten Nachfragemuster den aktuellen Boom sogar noch beflügelt. Beton ist mehr denn je „Gold“!
Conductive printable electrodes tuned by boron-doped nanodiamond foil additives for nitroexplosive detection
Authors: Dettlaff Anna , Rycewicz Michał , Ficek Mateusz , Wieloszyńska Aleksandra , Szala Mateusz , Ryl Jacek , Bogdanowicz Robert 
Published: July 2022

Abstract
An efficient additive manufacturing-based composite material fabrication for electrochemical applications is reported. The composite is composed of commercially available graphene-doped polylactide acid (G-PLA) 3D printouts and surface-functionalized with nanocrystalline boron-doped diamond foil (NDF) additives. The NDFs were synthesized on a tantalum substrate and transferred to the 3D-printout surface at 200 °C. No other electrode activation treatment was necessary. Different configurations of low- and heavy-boron doping NDFs were evaluated. The electrode kinetics was analyzed using electrochemical procedures: cyclic voltammetry and electrochemical impedance spectroscopy. The quasi-reversible electrochemical process was reported in each studied case. The studies allowed confirmation of the CV peak-to-peak separation of 63 mV and remarkably high heterogeneous electron transfer rate constant reaching 6.1 × 10−2 cm s−1 for 10 k ppm [B]/[C] thin NDF fitted topside at the G-PLA electrode. Differential pulse voltammetry was used for effective 2,4,6-trinitrotoluene (TNT) detection at the studied electrodes with a 87 ppb limit of detection, and wide linearity range between peak current density and the analyte concentration (0.064 to 64 ppm of TNT). The reported electrode kinetic differences originate primarily from the boron-dopant concentration in the diamond and the various contents of the non-diamond carbon phase.
Graphical abstract
Einfluss verschiedener automatisierter externer Defibrillatoren auf die Hands-off-Intervalle von Ersthelfern
Authors: Schäfer Volker , Witwer Patrick , Schwingshackl Lisa , Salchner Hannah , Gasteiger Lukas , Schabauer Wilfried , Lederer Wolfgang 
Published: July 2022

Zusammenfassung
Hintergrund
Die Überlebenschancen nach prähospitalen Herz-Kreislauf-Stillständen mit hyperdynamen elektrischen Herzrhythmen können durch frühzeitige Defibrillation mit einem automatisierten externen Defibrillator signifikant verbessert werden. Entsprechend den internationalen Leitlinien dürfen die daraus resultierenden Hands-off-Intervalle nicht mehr als 10 s betragen.

Ziel der Arbeit
Wir untersuchten die Verzögerung des Beginns der Herzdruckmassage und die Dauer der Hands-off-Intervalle während der Reanimation, die mit der Anwendung von automatisierten externen Defibrillatoren in Zusammenhang stehen.

Material und Methoden
In einer prospektiven, randomisierten, einfach verblindeten Beobachtungsstudie wurden Reanimationsmaßnahmen von Medizinstudent*Innen im ersten Semester in verschiedenen Notfallszenarien am Phantom getestet. Verglichen wurden die Verzögerung des Beginns der Herzdruckmassage und die Dauer der Hands-off-Intervalle durch Sprachanweisungen von vier konventionellen Geräten bei defibrillierbaren und nichtdefibrillierbaren Rhythmen. Zufriedenheit mit dem Gerät, Schwierigkeiten bei der Anwendung und Verbesserungsvorschläge wurden über Fragebogen erfasst.

Ergebnisse
In insgesamt 70 Anwendungen wurde der Beginn der Herzdruckmassage durch die Sprachanweisungen um durchschnittlich 115 s verzögert. Bei defibrillierbaren Rhythmen wurde der erste Schock im Mittel erst nach 125 s ausgelöst. Unterbrechungen nach Schockabgabe von unter 10 s wurden mit keinem der getesteten Geräte erreicht. Die Hands-off-Intervalle während der Defibrillationen unterschieden sich signifikant zwischen den Geräten (p < 0,001). Verbesserungsvorschläge wurden für die Bereiche Gerätemarkierungen, Sprachanweisungen und Elektroden gemacht.

Diskussion
Perischockpausen von unter 10 s konnten mit keinem der getesteten Geräte erreicht werden. Kürzere und konkretere Sprachanweisungen sowie übersichtlichere Beschriftung und Anordnung der Elektroden sind nötig, um die Anwendung zu vereinfachen, den Beginn der Herzdruckmassage weniger zu verzögern und die Hands-off-Intervalle zu verkürzen.
Developing and Validating Multi-Modal Models for Mortality Prediction in COVID-19 Patients: a Multi-center Retrospective Study
Authors: Wu Joy Tzung-yu , de la Hoz Miguel Ángel Armengol , Kuo Po-Chih , Paguio Joseph Alexander , Yao Jasper Seth , Dee Edward Christopher , Yeung Wesley , Jurado Jerry , Moulick Achintya , Milazzo Carmelo , Peinado Paloma , Villares Paula , Cubillo Antonio , Varona José Felipe , Lee Hyung-Chul , Estirado Alberto , Castellano José Maria , Celi Leo Anthony 
Published: July 2022

AbstractThe unprecedented global crisis brought about by the COVID-19 pandemic has sparked numerous efforts to create predictive models for the detection and prognostication of SARS-CoV-2 infections with the goal of helping health systems allocate resources. Machine learning models, in particular, hold promise for their ability to leverage patient clinical information and medical images for prediction. However, most of the published COVID-19 prediction models thus far have little clinical utility due to methodological flaws and lack of appropriate validation. In this paper, we describe our methodology to develop and validate multi-modal models for COVID-19 mortality prediction using multi-center patient data. The models for COVID-19 mortality prediction were developed using retrospective data from Madrid, Spain (N = 2547) and were externally validated in patient cohorts from a community hospital in New Jersey, USA (N = 242) and an academic center in Seoul, Republic of Korea (N = 336). The models we developed performed differently across various clinical settings, underscoring the need for a guided strategy when employing machine learning for clinical decision-making. We demonstrated that using features from both the structured electronic health records and chest X-ray imaging data resulted in better 30-day mortality prediction performance across all three datasets (areas under the receiver operating characteristic curves: 0.85 (95% confidence interval: 0.83–0.87), 0.76 (0.70–0.82), and 0.95 (0.92–0.98)). We discuss the rationale for the decisions made at every step in developing the models and have made our code available to the research community. We employed the best machine learning practices for clinical model development. Our goal is to create a toolkit that would assist investigators and organizations in building multi-modal models for prediction, classification, and/or optimization.