bluuebunny/crossref_metadata_2025_split huggingface dataset:
Toward Holistic Design of Spatial Packaging of Interconnected Systems With Physical Interactions (SPI2)
Authors: Peddada Satya R. T. , Zeidner Lawrence E. , Ilies Horea T. , James Kai A. , Allison James T. 
Published: July 2022

Abstract
Three-dimensional spatial packaging of interconnected systems with physical interactions (SPI2) design plays a vital role in the functionality, operation, energy usage, and life cycle of practically all engineered systems, from chips to ships. SPI2 design problems are highly nonlinear, involving tightly constrained component placement, governed by coupled physical phenomena (thermal, hydraulic, electromagnetic, etc.), and involve energy and material transfer through intricate geometric interconnects. While many aspects of engineering system design have advanced rapidly in the last few decades through breakthroughs in computational support, SPI2 design has largely resisted automation and in practice requires at least some human-executed design steps. SPI2 system reasoning and design decisions can quickly exceed human cognitive abilities at even moderate complexity levels, thwarting efforts to accelerate design cycles and tackle increasingly complex systems. Existing design methods treat pieces of the SPI2 problem separately without a fundamental systems approach, are sometimes inefficient to evaluate various possible designs, and present barriers to effective adoption in practice. This article explores a vision of a holistic SPI2 design approach needed to develop next-generation automated design methods capable of rapidly producing viable SPI2 design candidates. We review several technical domains related to holistic SPI2 design, discuss existing knowledge gaps and practical challenges, examine exciting opportunities at the intersection of multiple domains that can enable comprehensive exploration of SPI2 design spaces, and present one viable two-stage SPI2 design automation framework. Holistic SPI2 design opens up a new direction of high industrial and societal relevance for the design research community.
A Shock Loss Reduction Method Using a Concave Suction Side Profile for a Zero Inlet Swirl Turbine Rotor
Authors: Zhou Qinghui , Zhao Wei , Sui Xiuming , Zhao Qingjun , Xu Jianzhong 
Published: July 2022

Abstract
A zero inlet swirl turbine rotor (ZISTR) works with axial inlet gas flow directly exhausted from a combustion chamber without any upstream vanes. The suction side trailing edge shock of the ZISTR generates a significant amount of aerodynamic loss. A shock loss reduction method is presented for the ZISTR. The principle of the method is to replace the single shock by double shocks. For minimizing the shock loss, the strength of the double shocks is set to be equal. This is based on a design criterion that multiple shocks should be with equal strength to achieve the minimum shock loss. This design criterion has been widely used for supersonic inlet design, but it is first extended to the transonic turbine design in the present article. A shock model, using aerodynamic relations of oblique shock, is put forward to quantitatively determine the shape of the concave suction-side profile. Numerical simulations indicate that the concave suction-side profile induces a new shock upstream of the suction-side trailing edge shock, and these two shocks are with nearly equal strength in the improved ZISTR. The shock loss of the improved ZISTR is obviously reduced. The concave tip profile would redistribute the blade load on the tip and increase the tip leakage flow loss. Hence, it is suggested that the concave profiles should be designed between 0% and 80% blade span, and the tip profile should keep unchanged. The improved ZISTR with an unchanged tip profile achieves an improvement of turbine efficiency by 0.8% at the design condition.
Tracking of Walking and Running for Exercise: Alignment Between Ecological Momentary Assessment and Accelerometer-Based Estimates
Authors: Strohacker Kelley , Toth Lindsay P. , Sheridan Lucas F. , Crouter Scott E. 
Published: July 2022

Ecological momentary assessment (EMA) and accelerometer-based devices can be used concurrently to better understand dimensions of physical activity. This study presents procedures for analyzing data derived from both methods to examine exercise-related walking and running, as well as determine evidence for alignment between these methods. The participants (N = 29) wore an ActiGraph GT3X+ and completed four EMA surveys/day across 2 weeks to report exercise (mode and duration). GT3X+ counts per 10 s were processed using the Crouter two-regression model to identify periods of walking/running (coefficient of variation in activity counts ≤10% and >0%). Two reviewers visually inspected Crouter two-regression model data and recorded durations of walking/running in time blocks corresponding to EMA reports of exercise. The data were classified as “aligned” if the duration of walking/running between methods were within 20% of one another. Frequency analyses determined the proportion of aligned versus nonaligned exercise durations. Reviewer reliability was examined by calculating interobserver agreement (classification of aligned vs. nonaligned) and intraclass correlation coefficients (ICC; duration based on coefficient of variation). Of the 139 self-reported bouts of walking and running exercise, 25% were classified as aligned with the Crouter two-regression model coefficient of variation. Initial interobserver agreement was 91, and ICCs across data classified as aligned (ICC = .992) and nonaligned (ICC = .960) were excellent. These novel procedures offer a means of isolating exercise-related physical activity for further analysis. Due to the inability to align evidence in most cases, we discuss key considerations for optimizing EMA survey questions, choice in accelerometer-based device, and future directions for visual analysis procedures.
Preliminary X-ray Diffraction Analysis of the Envelope (E) Protein of Far-Eastern Tick-Borne Encephalitis Virus Subtype (Sofjin Strain)
Authors: Dubova K. M. , Vlaskina A. V. , Korzhenevskiy D. A. , Agapova Yu. K. , Rakitina T. V. , Samygina V. R. 
Published: July 2022

Abstract
The envelope (E) protein of flaviviruses is an attractive target for the development of antiviral agents because this protein plays an important role in the formation of virus particles and in the virus invasion in host cells. Currently, there is no specific antiviral therapy for tick-borne encephalitis. The goal of this study is to determine the crystal structure of the envelope (E) protein ectodomain of Far-Eastern tick-borne encephalitis virus subtype (Sofjin strain). The knowledge of the three-dimensional structure can serve as the basis for the development of specific inhibitors of conformational rearrangements of the (E) protein, which are essential for the initial stages of infection.
Patient journey in erosive oesophagitis: real-world perspectives from US physicians and patients
Authors: Vaezi Michael F , Brunton Stephen , Mark Fendrick A , Howden Colin W , Atkinson Christian , Pelletier Corey , Jacob Rinu , Spechler Stuart J 
Published: July 2022

ObjectiveManagement of erosive oesophagitis (EE) remains suboptimal, with many patients experiencing incomplete healing, ongoing symptoms, and relapse despite proton pump inhibitor (PPI) treatment. The Study of Acid-Related Disorders investigated patient burden of individuals with EE in a real-world setting.DesignUS gastroenterologists (GIs) or family physicians (FPs)/general practitioners (GPs) treating patients with EE completed a physician survey and enrolled up to four patients with EE for a patient survey, with prespecified data extracted from medical records.Results102 GIs and 149 FPs/GPs completed the survey; data were available for 73 patients (mean age at diagnosis, 45.4 years). Omeprazole was healthcare professional (HCP)-preferred first-line treatment (60.8% GIs; 56.4% FPs/GPs), and pantoprazole preferred second line (29.4% and 32.9%, respectively). Price and insurance coverage (both 55.5% HCPs) and familiarity (47.9%) key drivers for omeprazole; insurance coverage (52.0%), price (50.0%), familiarity (48.0%), initial symptom relief (46.0%), and safety (44.0%) key drivers for pantoprazole. Only 49.3% patients took medication as instructed all the time; 56.8% independently increased medication frequency some of the time. Despite treatment, 57.5% patients experienced heartburn and 30.1% regurgitation; heartburn was the most bothersome symptom. 58.9% patients believed that their symptoms could be better controlled; only 28.3% HCPs were very satisfied with current treatment options. 83.6% patients wanted long-lasting treatment options. Fast symptom relief for patients was a top priority for 66.1% HCPs, while 56.6% would welcome alternatives to PPIs.ConclusionThis real-world multicentre study highlights the need for new, rapidly acting treatments in EE that reduce symptom burden, offer durable healing and provide symptom control.
Impact of hospital readiness on patient safety incidents during the COVID-19 pandemic in Indonesia: health worker perceptions
Authors: Dhamanti Inge , Indriani Diah , Miftahussurur Muhammad , Kurniawati Eva , Engineer Cyrus Y 
Published: July 2022

ObjectivesThis study examined the impact of hospital readiness on patient safety from the healthcare workers’ perspective.DesignThe study employed a mixed-methods explanatory sequential design, with the quantitative phase taking precedence. We conducted an online survey of 235 healthcare workers at COVID-19 referral hospitals, followed by an interview with 11 participants from various hospital types.SettingCOVID-19 referral hospitals in Indonesia.ParticipantsHealth workers working at COVID-19 referral hospitals.MeasuresHospital ownership; hospital accreditation status; hospital readiness including incident management system, surge capacity, infection control and prevention, and human resource management; patient safety incident.ResultsAccording to the survey, 66.4% of the participants worked at a hospital owned by the provincial or district government, and 69.4% worked at a hospital which had received an excellent status accreditation. More than 80% of the hospitals scored well in the categories of the incident management system (86%), surge capacity (80.9%), infection control and prevention (97.9%), and human resource management (84.7%). However, only 50.6% of the hospitals scored well in managing patient safety incidents. Hospital ownership, accreditation status and hospital readiness all have an impact on patient safety incidents, which were reported in all types of hospitals by both studies.ConclusionsThis study provides significant results for Indonesia in terms of hospital preparedness and patient safety for the COVID-19 pandemic. The accreditation and ownership status of the hospital have aided hospital readiness. Despite the fact that no hospital in the world was prepared for the COVID-19 pandemic, hospital readiness has improved a year later; however, patient safety has not improved. Patient safety incidents occurred regardless of hospital status, with the most common occurrence being delayed treatment. Administrative errors were also recorded in COVID-19 field hospitals that were not accredited. Future research should focus on improving pandemic care quality and implementing initiatives that are applicable to all types of hospitals.
Future of mental health in the metaverse
Authors: Usmani Sadia Suhail , Sharath Medha , Mehendale Meghana 
Published: July 2022

The metaverse and non-fungible tokens (NFTs) were some of the hottest tech terms in 2021, according to a Google Trends search. Our review aims to describe the metaverse and NFTs in the context of their potential application in the treatment of mental health disorders. Advancements in technology have been changing human lives at an ever-increasing pace. Metaverse, also known as the three-dimensional (3D) internet, is the convergence of virtual reality (VR) and physical reality in a digital space. It could potentially change the internet as we know it, with NFTs as the key building blocks in the new expansive virtual ecosystem. This immersive 3D virtual world boasts the features of the real world with the added ability to change the surrounding environment according to individual needs and requirements. VR, augmented reality (AR) and mixed reality (MR) have been employed as tools in the treatment of various mental health disorders for the past decade. Studies have reported positive results on their effectiveness in the diagnosis and treatment of mental health disorders. VR/AR/MR have been hailed as a solution to the acute shortage of mental health professionals and the lack of access to mental healthcare. But, on the flip side, young adults tend to spend a significant amount of time playing 3D immersive games and using social media, which can lead to insecurity, anxiety, depression, and behavioural addiction. Additionally, endless scrolling through social media platforms negatively affects individuals' attention span as well as aggravating the symptoms of adolescents with attention deficit hyperactivity disorder.We aimed to explore the ramifications of expanding applications of the metaverse on mental health. So far, no other review has explored the future of mental health in the context of the metaverse.
A digital pathway for genetic testing in UK NHS patients with cancer: BRCA-DIRECT randomised study internal pilot
Authors: Torr Bethany , Jones Christopher , Choi Subin , Allen Sophie , Kavanaugh Grace , Hamill Monica , Garrett Alice , MacMahon Suzanne , Loong Lucy , Reay Alistair , Yuan Lina , Valganon Petrizan Mikel , Monson Kathryn , Perry Nicky , Fallowfield Lesley , Jenkins Valerie , Gold Rochelle , Taylor Amy , Gabe Rhian , Wiggins Jennifer , Lucassen Anneke , Manchanda Ranjit , Gandhi Ashu , George Angela , Hubank Michael , Kemp Zoe , Evans D Gareth , Bremner Stephen , Turnbull Clare 
Published: July 2022

BackgroundGermline genetic testing affords multiple opportunities for women with breast cancer, however, current UK NHS models for delivery of germline genetic testing are clinician-intensive and only a minority of breast cancer cases access testing.MethodsWe designed a rapid, digital pathway, supported by a genetics specialist hotline, for delivery of germline testing ofBRCA1/BRCA2/PALB2(BRCA-testing), integrated into routine UK NHS breast cancer care. We piloted the pathway, as part of the larger BRCA-DIRECT study, in 130 unselected patients with breast cancer and gathered preliminary data from a randomised comparison of delivery of pretest information digitally (fully digital pathway) or via telephone consultation with a genetics professional (partially digital pathway).ResultsUptake of genetic testing was 98.4%, with good satisfaction reported for both the fully and partially digital pathways. Similar outcomes were observed in both arms regarding patient knowledge score and anxiety, with <5% of patients contacting the genetics specialist hotline. All progression criteria established for continuation of the study were met.ConclusionPilot data indicate preliminary demonstration of feasibility and acceptability of a fully digital pathway for BRCA-testing and support proceeding to a full powered study for evaluation of non-inferiority of the fully digital pathway, detailed quantitative assessment of outcomes and operational economic analyses.Trial registration numberISRCTN87845055.
Use of a head-mounted patient display in a task driven anaesthesia simulator: a randomised trial
Authors: Cole Jacob Henry , Hughey S 
Published: July 2022

IntroductionHead-mounted displays (HMDs) are becoming increasingly investigated in the realm of healthcare. These devices are worn on the user’s head and display information directly to the eye. This allows for near-constant delivery of information, regardless of user position. Increasing advances in technology have allowed for miniaturisation, increasing sophistication, wireless capability and prolonged battery life, all of which allow for more opportunities for these devices to be used in a clinical setting.MethodsA prospective, randomised, controlled, parallel-group study was conducted. Subjects were randomised to either an HMD group or a non-HMD group. All subjects then underwent a standardised intraoperative care simulation experience consisting of multiple procedures that required completion within a set time limit. During this period, subjects concurrently monitored the physiological state of a simulated patient. Multiple standardised physiological derangements were displayed to the subjects via either the worn HMD or standard monitors. The primary outcome was the time to recognition of these physiological derangements.ResultsA total of 39 anaesthesia providers were enrolled in this study. There was a significant decrease in the total time it took them to recognise the simulated physiological derangements in the HMD group (difference of 38.2% (95% CI 20.3% to 56.1%); p=0.011) No significant differences in the time that it took to perform the required simulated procedures were observed. Significantly fewer physiological derangements were overlooked by the HMD group than the control group overall (relative risk reduction 0.78 (95% CI 0.31 to 0.94); p=0.003).ConclusionsRecent advances in HMD technology may be able to produce a functional adjunctive monitoring device that improves the speed with which anaesthesia providers respond to intraoperative events. This benefit comes without increasing distraction from the task. Further studies in true operative environments are needed to validate this technology.
Return to flying duties of German military pilots after recovery from COVID-19
Authors: Adam Tim , Sammito S , Nicol E , Guettler N J 
Published: July 2022

BackgroundPilots are working in a unique and exacting environment with hypobaric hypoxia and acceleration forces. In military flying, missions are often challenging with possible combat scenarios and in remote areas with impaired infrastructure.MethodsWe analysed all German military pilots and pilot candidates with confirmed SARS-CoV-2 infection, who have all been evaluated prior to their return to flying duties between April 2020 and January 2022 by the German Air Force Centre of Aerospace Medicine. Symptoms, comorbidities, scope of investigations, examination results, vaccination status and aeromedical disposition are described.Results90 pilots (82 active pilots and 8 pilot candidates) with a median age of 35 years (IQR 15 years) were included. 78 pilots (87%) reported symptoms, with median duration of 6 days. Symptoms included influenza-like symptoms (70.0%), headache (45.6%), impaired physical fitness (37.8%), anosmia/ageusia (36.7%), fever (27.8%), exertional dyspnoea (8.9%), memory and concentration disorders (4.4%), diarrhoea (3.3%) and dyspnoea at rest (2.2%). Only one pilot (1.1%) was hospitalised, two (2.2%) required outpatient treatment. All pilots were allowed to return to unrestricted flying duties after the assessment, with eight (8.9%) reporting ongoing mild symptoms.ConclusionDue to their demanding working environment, pilots, and other high-hazard employees, should undergo medical evaluation prior to return to their duties to exclude ongoing symptoms and the development of post-acute COVID-19 or post-COVID-19 syndrome. The scope of examinations may depend on the severity of the disease, comorbidities, the vaccination status, the predominant SARS-CoV-2 variant and the type of aircraft flown.
Recurrence of axial spondyloarthritis among first-degree relatives in a prospective 35-year-follow-up family study
Authors: van der Linden Sjef M , Khan Muhammad Asim , Li Zhixiu , Baumberger Heinz , Zandwijk Hermine van , Khan Mohammad Kazim , Villiger Peter M , Brown Matthew A 
Published: July 2022

ObjectiveThe lifetime recurrence rate (RR) of axial spondyloarthritis (axSpA) among first-degree relatives (FDR) and the effect of proband’s gender, HLA-B27 and radiographic status is unclear. Our 35-year-follow-up family study has enabled these issues to be addressed.MethodsIn 1985, 363 ankylosing spondylitis (AS) probands (members of the Swiss AS Patient Society) and 806 FDR recruited into the study, completed questionnaires regarding axSpA manifestations, underwent a physical examination and most also underwent pelvic radiography and HLA-B27 typing. At follow-up in 2018–2019, of the former participants whose current addresses could be retrieved, 162 had died and 485 (125 patients with AS plus 360 FDR) completed a postal questionnaire.ResultsAt follow-up, 48 of 177 HLA-B27(+) FDR had developed axSpA, an RR of 27.1% (95% CI 20.6% to 33.7%). 27/148 (18.2%) children of AS probands (modified New York (mNY) criteria) were affected versus 2/50 (4.0%) children of non-radiographic axSpA probands (p=0.0138, OR=5.36; 95% CI 1.23 to 23.40). Children of female probands were more often affected (12/22; 54.5%) than of male probands (15/78; 19.2%) (p=0.0003; OR=4.89; 95% CI 1.96 to 12.23). This increased risk applies equally to sons and daughters.ConclusionThe lifetime RR of axSpA for HLA-B27(+) FDR is substantial (27.1%), and disease severity (as defined by radiographic sacroiliitis by the mNY criteria) is an additional risk factor. Affected mothers pass on the disease significantly more often to their offspring than do affected fathers. These findings may lead to better assessment of lifetime risk for axSpA in the offspring. Moreover, investigation of this gender effect may uncover additional putative disease susceptibility factors.
Gravitational waves at the first post-Newtonian order with the Weyssenhoff fluid in Einstein–Cartan theory
Authors: Battista Emmanuele , De Falco Vittorio 
Published: July 2022

AbstractThe generation of gravitational waves from a post-Newtonian source endowed with a quantum spin, modeled by the Weyssenhoff fluid, is investigated in the context of Einstein–Cartan theory at the first post-Newtonian level by resorting to the Blanchet–Damour formalism. After having worked out the basic principles of the hydrodynamics in Einstein–Cartan framework, we study the Weyssenhoff fluid within the post-Newtonian approximation scheme. The complexity of the underlying dynamical equations suggests to employ a discrete description via the point-particle limit, a procedure which permits the analysis of inspiralling spinning compact binaries. We then provide a first application of our results by considering binary neutron star systems.
Study of null and time-like geodesics in the exterior of a Schwarzschild black hole with quintessence and cloud of strings
Authors: Fathi Mohsen , Olivares Marco , Villanueva J. R. 
Published: July 2022

AbstractRecently, an analytical study of radial and circular orbits for null and time-like geodesics that propagate in the spacetime produced by a Schwarzschild black hole associated with cloud of strings, in a universe filled by quintessence, has been done in Mustafa and Hussain (Eur Phys J C 81:419, 2021). In this paper, we complete the aforementioned study by investigating possible analytical solutions to the equations of motion for other types of bound orbits, beside taking into account the cases of unbound orbits. This requires an extensive study of the corresponding effective potentials that categorize the test particle motion. We follow the standard Lagrangian dynamics to parametrize the radial and angular geodesics and the resultant (hyper-)elliptic integrals of motion are treated accordingly. We also simulate the orbits which correspond to different levels of energy in the effective potentials.