bluuebunny/crossref_metadata_2025_split huggingface dataset:
Large size, sensitive response thermally expandable microspheres for the manufacture of suede‐like leather
Authors: Wei Huan , Luo Haihang , Li Jing , Fan Haojun , Xiang Jun , Chen Yi , Yan Jun 
Published: November 2022

AbstractA large size, sensitive response thermally expandable microspheres (TEMs) for suede‐like leather manufacture was prepared by suspension polymerization using acrylonitrile (AN), methyl methacrylate (MMA) and vinyl acetate (VAC) as the shell monomers and iso‐pentane as the foaming component. The effect of the interfacial tension and viscosity of polymerization system on the particle size of TEMs, and in turn, the effect of the particle size of TEMs on the expansion temperature, expansion ratio and thermal response performance were investigated in detail. The results showed that increasing the interface tension and viscosity of the polymerization system was beneficial for preparing large size TEMs. Under the optimized conditions of 300 rpm, 25 wt% iso‐pentane dosage, and 9:3:1 mass ratio of AN/MAA/VAC, the TEMs shown above 100 μm particle size and 4 times expansion ratio at 150°C. Moreover, TEMs with 18% encapsulation ratio (Er) of the foaming component can complete foaming in the narrow temperature range (ΔT ≤ 10°C), showing a sensitive thermal response. The mixture of waterborne polyurethane and quantitative TEMs was coated on the surface of synthetic leather base, and a new type of suede‐like leather was obtained after foaming, which can substitute genuine suede leather.
Low‐intensity low‐frequency ultrasound mediates riboflavin delivery during corneal crosslinking
Authors: Sun Zhe , Li Zhiming , Chung Jin Teng , Lau Laurence Chi Ming , Jhanji Vishal , Chau Ying 
Published: November 2022

AbstractWe employed the mechanical effect from 40 kHz ultrasound (US) to improve the delivery of riboflavin into corneal stroma for collagen crosslinking, which can benefit the treatment of keratoconus and other corneal ectasias. Experiments were conducted, first with porcine corneas ex vivo and then with New Zealand white rabbits in vivo, at varying mechanical index (MI) and sonication time. Results showed that 15 min of US applied on the cornea at MI = 0.8 in the presence of 0.5% of riboflavin solution enabled its delivery to deeper corneal stroma. Excessive heat was removed by a cooling setup to negate the thermal effect. The corneal absorption amount and penetration of riboflavin through cornea as detected by fluorotron, as well as the enhancement of corneal stiffness as measured by Young's modulus, were comparable to the conventional approach that requires complete corneal epithelium debridement. Histological analysis revealed minor exfoliation of superficial cell layers of corneal epithelium and loss of ZO‐1 tight junctions immediately after US. Full recovery of the corneal epithelium and restoration of tight junctions occurred in 3–4 days. The study shows that low‐intensity low‐frequency ultrasound (LILF US) is a less invasive alternative to the conventional epithelium‐off method for delivering riboflavin into the corneal stroma.
Endocrine therapy initiation and overall survival outcomes with omission of radiation therapy in older Medicare patients with early‐stage hormone‐receptor‐positive breast cancer
Authors: Shen Chan , Li Ning , Zhou Shouhao , Stahl Kelly , Dodge Daleela , Zhao Hui 
Published: November 2022

AbstractBackgroundGuidelines allow for the omission of radiotherapy in older women with early‐stage, hormone‐receptor‐positive breast cancer, given that the patients receive adequate endocrine therapy (ET). However, the initiation of ET and survival outcomes after forgoing radiation therapy among these patients have not been well‐studied.MethodsWe identified patients aged 70 to 90 years old newly diagnosed in 2010–2015 with early‐stage, hormone receptor positive, and human epidermal growth factor receptor 2 (HER2) negative (HR+/Her2−) breast cancer who received lumpectomy and omitted radiation therapy using the SEER‐Medicare database. We examined the initiation of ET and the utilization patterns of ET using a multivariable logistic regression. We further examined the overall survival outcomes using Kaplan–Meier estimation and Cox proportional hazard model with inverse probability weighting.ResultsOf the 2618 patients, 808 (30.9%) received no ET. The multivariable logistic regression showed that more recent years had better ET initiation (2013–2015 vs. 2010–2012: OR = 1.39, 95% CI:[1.16, 1.66]), while older patients (81–90 vs. 70–80: OR = 0.45, 95% CI:[0.38, 0.54]) were less likely to receive ET. Both the Kaplan–Meier estimation (log‐rank p‐value<0.0001) and the Cox proportional hazard model with inverse probability weighting (HR = 0.76, 95% CI:[0.58, 0.99]) showed that receiving ET was associated with better overall survival.ConclusionThis population‐based study suggests that a sizable proportion of patients who omitted radiation did not receive endocrine therapy and receiving endocrine therapy was beneficial among these patients. Although ET initiation has improved in more recent years, certain patient groups were still especially susceptible to no endocrine therapy.
Callicarpanes A–L, Twelve New Clerodane Diterpenoids with NLRP3 Inflammasome Inhibitory Activity from Callicarpa integerrima
Authors: Bi De‐Wen , Zhao Ying‐Xin , Qiu Xiong , Zhang Xue‐Cong , Zhou Ya‐Ling , Zeb Muhammad Aurang , Pang Wen‐Hui , Li Rui , Wang Meng‐Ru , Cheng Bin , Zhang Jing‐Jing , Zhang Xing‐Jie , Li Xiao‐Li , Zhang Rui‐Han , Xiao Wei‐Lie 
Published: November 2022

AbstractTwelve new clerodane diterpenoids named callicarpanes A–L (1–12), together with eight known compounds (13–20), were isolated from Callicarpa integerrima. Their structures were determined by comprehensive spectroscopic data. The calculated chemical shifts were used to identify relative configurations using DP4+ analysis. The absolute configurations (AC) were assigned based on quantum chemical calculations and X‐ray single‐crystal diffraction methods. Compounds 1, 3, 5, 9, 10, 12, 15, 16, and 19 showed significant inhibitory activity for NLRP3 inflammasome activation, with the IC50 against lactate dehydrogenase (LDH) release ranging from 0.08 to 4.78 μM. Further study revealed that compound 10 repressed IL‐1β secretion and caspase‐1 maturation in J774A.1 cell as well as blocked macrophage pyroptosis.
Fluorescent Nanoassemblies in Water Exhibiting Tunable LCST Behavior and Responsive Light Harvesting Ability
Authors: Xiao Tangxin , Tang Lu , Ren Dongxing , Diao Kai , Li Zheng‐Yi , Sun Xiao‐Qiang 
Published: November 2022

AbstractResponsive fluorescent nanomaterials have been received considerable attention in recent years. In this work, a bola‐type amphiphilic molecule, CSO, was synthesized which contains a hydrophobic cyanostilbene core and hydrophilic oligo(ethylene glycol) (OEG) coils at both sides. The cyanostilbene group is aggregation‐induced emission (AIE) active, while the OEG coils are thermo‐responsive. As a result, the CSO molecules can self‐assemble into blue‐fluorescent nanoassemblies with lower critical solution temperature (LCST) behavior in aqueous media. It is noteworthy that the LCST behavior can be reversibly regulated with changes in concentration and the introduction of K+. Intriguingly, fluorescence of CSO assembly shows a blue‐shift upon heating. Finally, by employing CSO as a light capturing antenna and energy donor, an artificial light harvesting system with tunable emission and thermo‐responsive characteristics was fabricated. This study not only demonstrates an integrated approach to create responsive fluorescent nanomaterials, but also shows great potential for producing luminescent materials and mimicking photosynthesis in nature.
Explicit distributed model predictive control design for chemical processes under constraints and uncertainty
Authors: Teng Yiming , Bai Jianjun , Wu Feng , Zou Hongbo 
Published: November 2022

AbstractIn multivariable industrial processes, the common distributed model predictive control strategy is usually unable to deal with complex large‐scale systems efficiently, especially under system constraints and high control performance requirements. Based on this situation, we use the distributed idea to divide the large‐scale system into multiple subsystems and transform them into the state space form. Combined with the output tracking error term, we build an extended non‐minimal state space model that includes output error and measured output and input. When dealing with system constraints, the new constraint matrix is divided into range and kernel space by using the explicit model predictive control algorithm, which reduces the difficulty of solving constraints in the extended system and further improves the overall control performance of the system. Finally, taking the coke furnace pressure control system as an example, the proposed algorithm is compared with the conventional distributed model predictive control algorithm using non‐minimal state space, and the simulation results show the feasibility and superiority of this method.
The clinicopathological significance and relapse predictive role of tumor microenvironment of intrahepatic cholangiocarcinoma after radical surgery
Authors: Zheng Yiling , Huang Ning , Kuang Shuwen , Zhang Jing , Zhao Hong , Wu Jianxiong , Liu Mei , Wang Liming 
Published: November 2022

AbstractBackgroundThis study attempts to detect the expression of FoxP3, CD68, CD8α, and PD‐L1 in the tumor microenvironment (TME) of intrahepatic cholangiocarcinoma (ICC), and analyze the relationship between the corresponding cells and clinicopathological characteristics as well as prognosis of ICC.MethodsRNA sequencing (RNA‐seq) provided the general landscape of the TME in ICC. A total of 99 ICC patients and the corresponding specimens were used for multiplex immunofluorescence and relapse‐free survival (RFS) was analyzed. Flow cytometry further validated the effect of regulatory T (Treg) cells on ICC relapse.ResultsRNA‐seq data showed that the infiltration of Treg cells, CD8+ T cells, and macrophages were likely associated with ICC relapse. The survival analysis based on multiplex immunofluorescence showed that the high FoxP3(+) Treg cells ratio and low CD68(+) macrophages ratio in mesenchyme were associated with higher RFS rate, respectively. Low FoxP3(+) Τreg cells ratio was associated with more perineural invasion, and high CD68(+) macrophages ratio was correlated with more lymph node metastasis. Cox regression analysis revealed that FoxP3(+) Treg cells ratio was an independent predictive factor for ICC relapse. Flow cytometry showed that TregIII was the predominant Treg cell subtype in both tumor tissue and peripheral blood of ICC patients, and high TregIII abundance in peripheral blood was significantly associated with longer RFS of ICC patients.ConclusionHigh FoxP3(+) Treg cells ratio in the mesenchyme of ICC tumor tissue predicted longer RFS and was an independent favorable prognostic factor for ICC patients. Among all Treg cell subtypes, TregIII in peripheral blood was correlated with the RFS of ICC patients.
Emergency steering collision avoidance control based on distributed driving intelligent vehicles
Authors: Zhu Shaopeng , Wei Bangxuan , Chen Chaoxin , Gao Jian , Ning Wenbo , Huang Zhi 
Published: November 2022

SummaryBased on the distributed drive intelligent electric vehicle, considering the collision avoidance effect of the planned path, the path tracking accuracy, and the body stability requirements in the process of steering collision avoidance, this article proposes a control strategy for emergency steering collision avoidance. First, the fifth‐order polynomial method is used to generate collision avoidance paths, and then a designed cost function is used to evaluate and select the optimal collision avoidance path. Second, a decision‐making strategy that integrates multiple risk judgment models is built. Based on the model prediction method, a path tracking controller is built, and an optimization objective function is established to improve the tracking accuracy. In order to ensure the stability of the vehicle body, a vehicle stability controller is designed based on fuzzy theory. Finally, a vehicle‐in‐the‐loop intelligent driving algorithm test platform is built, and the control algorithm is tested through this platform. The test results show that compared with the pure path tracking control method, the control strategy is reasonable and effective and can better reduce the path tracking error and improve the vehicle's driving stability in the collision avoidance process.
Energy‐efficient animal tracking with multi‐unmanned aerial vehicle path planning using reinforcement learning and wireless sensor networks
Authors: Ergunsah Senol , Tümen Vedat , Kosunalp Selahattin , Demir Kubilay 
Published: November 2022

AbstractIn recent years, the integration of wireless sensor networks (WSNs) and unmanned aerial vehicles (UAVs) has been a popular research domain in animal tracking due to animal habitats in harsh environments. A well‐designed WSN network provides a robust mechanism to detect the animal appearances which can be then collected by UAVs. In this paper, we first design a WSN‐based network model that eliminates the deficiencies of traditional WSNs by intelligently building a WSN topology. Second, we propose a multi‐agent (UAVs) Q‐learning‐based trajectory planning algorithm, which enables UAVs to acquire the detection information of the wild animal on time. Q‐learning algorithm coordinates the UAVs to visit WSN nodes containing fresh animal detection data in a timely manner according to past experience. The experimental results denotes that the proposed animal tracking system delivers significantly higher timely animal detection messages of 45% than the existing algorithms and the single agent Q‐learning approaches. The results also show that since the Zebras' movement contains some randomness, relatively high epsilon value (0.2) in the epsilon‐greedy mechanism of the Q‐learning provides highest rewards (timely delivered messages) for agents (UAVs). In the light of the results, it is clearly seen that intelligently designed WSN and UAV swarm combination could enable tracking of the wild animal in near real time.
Support Vector Machine based spectrum handoff scheme for seamless handover in Cognitive Radio Networks
Authors: Iyer Srikrishna , Velmurugan Thangappa , Prakasam Periasamy , Sumathi Durairaj , Suresh Kumar Thengalpalayam Rajamanickam 
Published: November 2022

SummaryThe advancements in wireless communication go in leaps and bounds ushering in due attention to spectrum sharing. Spectrum scarcity is one of the major limitations causing hardships in the existing wireless networks. Cognitive Radio Networks (CRNs) emerge as a solution to tide over such humps. It prompts the secondary user (SU) to look out for unused spectrum and utilize them. The CRN helps the SU by permitting it to switch over to unused portions of the spectrum. When a primary user (PU) claims back the spectrum, SU is obliged to perform a spectrum handoff. The SU decides the type of policy to be chosen for the handoff. Such a decision‐making step during the handoff of the spectrum is imperative only if a changing policy is required. In this research work, Artificial Neural Networks (ANNs), Logistic Regression and Support Vector Machine (SVM) are proposed and implemented for a seamless handoff in CRN. From the experimental verifications, it is observed that the training accuracy is 97.9% and 97.6% for ANN and SVM, respectively. But during the actual phase, SVM to a certain extent performed better. This is due to the convergence nature of SVM on global minima.
Genetically encoded tools for in vivo G‐protein‐coupled receptor agonist detection at cellular resolution
Authors: Kroning Kayla E. , Wang Wenjing 
Published: November 2022

AbstractG‐protein‐coupled receptors (GPCRs) are the most abundant receptor type in the human body and are responsible for regulating many physiological processes, such as sensation, cognition, muscle contraction and metabolism. Further, GPCRs are widely expressed in the brain where their agonists make up a large number of neurotransmitters and neuromodulators. Due to the importance of GPCRs in human physiology, genetically encoded sensors have been engineered to detect GPCR agonists at cellular resolution in vivo. These sensors can be placed into two main categories: those that offer real‐time information on the signalling dynamics of GPCR agonists and those that integrate the GPCR agonist signal into a permanent, quantifiable mark that can be used to detect GPCR agonist localisation in a large brain area. In this review, we discuss the various designs of real‐time and integration sensors, their advantages and limitations, and some in vivo applications. We also discuss the potential of using real‐time and integrator sensors together to identify neuronal circuits affected by endogenous GPCR agonists and perform detailed characterisations of the spatiotemporal dynamics of GPCR agonist release in those circuits. By using these sensors together, the overall knowledge of GPCR‐mediated signalling can be expanded.
Evaluation of geranylgeranyl diphosphate synthase inhibition as a novel strategy for the treatment of osteosarcoma and Ewing sarcoma
Authors: Haney Staci L. , Feng Dan , Chhonker Yashpal S. , Varney Michelle L. , Williams Jacob T. , Smith Lynette M. , Ford James B. , Murry Daryl J. , Holstein Sarah A. 
Published: November 2022

AbstractRab GTPases are critical regulators of protein trafficking in the cell. To ensure proper cellular localization and function, Rab proteins must undergo a posttranslational modification, termed geranylgeranylation. In the isoprenoid biosynthesis pathway, the enzyme geranylgeranyl diphosphate synthase (GGDPS) generates the 20‐carbon isoprenoid donor (geranylgeranyl pyrophosphate [GGPP]), which is utilized in the prenylation of Rab proteins. We have pursued the development of GGDPS inhibitors (GGSI) as a novel means to target Rab activity in cancer cells. Osteosarcoma (OS) and Ewing sarcoma (ES) are aggressive childhood bone cancers with stagnant survival statistics and limited treatment options. Here we show that GGSI treatment induces markers of the unfolded protein response (UPR) and triggers apoptotic cell death in a variety of OS and ES cell lines. Confirmation that these effects were secondary to cellular depletion of GGPP and disruption of Rab geranylgeranylation was confirmed via experiments using exogenous GGPP or specific geranylgeranyl transferase inhibitors. Furthermore, GGSI treatment disrupts cellular migration and invasion in vitro. Metabolomic profiles of OS and ES cell lines identify distinct changes in purine metabolism in GGSI‐treated cells. Lastly, we demonstrate that GGSI treatment slows tumor growth in a mouse model of ES. Collectively, these studies support further development of GGSIs as a novel treatment for OS and ES.
Discovery of pyrazole‐carbohydrazide with indole moiety as tubulin polymerization inhibitors and anti‐tumor candidates
Authors: Man Ruo‐Jun , Lu Tian , Zheng Chi‐Chong , Li Tong , Wu Meng‐Ke , Li Dong‐Dong , He Xue‐Mei 
Published: November 2022

AbstractIn this work, a series of indole‐containing pyrazole‐carbohydrazide derivatives A1‐A25 were synthesized, and their biological activity on tubulin polymerization inhibition and mitotic catastrophe was evaluated. For introducing indole group to CA‐4 pattern, the carbohydrazide linker was used for the first time. As the top hit, A18 suggested notable antiproliferation efficacy and tubulin polymerization inhibitory activity. Inferring comparable antitubulin effect with the positive control Colchicine, A18 indicated obviously lower cyto‐toxicity. The cell scratch test showed that A18 could block the cell migration, while the confocal imaging depicted that A18 could induce the mitotic catastrophe via a Colchicine‐like approach. The docking simulation visualized the probable binding pattern of A18. With the information in this work, some new hints on modification might be involved in further tubulin‐related investigations.
Preliminary data on oxytocin modulation of neural reactivity in women to emotional stimuli of children depending on childhood emotional neglect
Authors: Meier Isabell M. , Montoya Estrella R. , Spencer Hannah , Orellana Sofia C. , van Buuren Mariët , van Honk Jack , Bos Peter A. 
Published: November 2022

AbstractSensitivity for rewarding cues and distress signals from children is fundamental to human caregiving and modulated by the neuropeptide oxytocin. In a functional magnetic resonance imaging study, we investigated whether oxytocin regulates neural responses to reward or distress cues form children. In a placebo‐controlled, within‐subject design, we measured neural responses to positive, negative, and neutral cues from children in 22 healthy female subjects who received oxytocin (24 IU) versus placebo. Further, based on current literature, we hypothesized that oxytocin effects are modulated by experiences of childhood trauma. The task elicited valence‐specific effects—positive images activated the ventromedial prefrontal cortex, left anterior cingulate cortex, and right putamen, and images of children in distress activated the bilateral amygdala, hippocampus, and right medial superior frontal cortex. The effects of oxytocin depended on subjective reports of childhood emotional neglect. Self‐reported neglect interacted with oxytocin administration in the amygdala, hippocampus, and prefrontal areas. In individuals with higher scores of emotional neglect, oxytocin increased neural reactivity of limbic structures to positive and neutral images. Our findings need replication in larger samples and can therefore be considered preliminary but are in line with the recent literature on the modulating effect of childhood adversity on the sensitivity to oxytocin administration.
Visible Light Organo‐Photocatalytic Synthesis of 3‐Imidazolines
Authors: Mishra Poornima , Shruti Ipsha , Kant Ruchir , Thakur Tejender S. , Kumar Akhilesh , Rastogi Namrata 
Published: November 2022

AbstractAn efficient regioselective synthesis of tetrasubstituted 3‐imidazolines under organo‐photocatalytic conditions has been developed through formal [3+2]‐cycloaddition between 2H‐azirines and N‐tosyl benzylidene imines. The products were isolated in high yields and as a separable mixture of diastereoisomers in most of the cases. The mild reaction conditions employing an organic dye as photocatalyst, excellent functional group tolerance, and high regioselectivity are notable features of the current protocol.
Protecting‐Group‐Free Total Synthesis of (−)‐Boscartin A in 3 Steps from (−)‐Boscartin F via Wharton Reaction
Authors: Kamo Shogo , Kasamatsu Akihiko , Shiraiwa Junya , Matsuzawa Akinobu , Sugita Kazuyuki 
Published: November 2022

AbstractIn this report, we described the first total synthesis of (−)‐boscartin A, a cembranoid featuring a 5/5/12‐fused tricyclic structure. Via the key reactions, including stereoselective epoxidation and Wharton reaction, (−)‐Boscartin A was obtained in three steps from (−)‐boscartin F, with 46 % overall yield.