bluuebunny/crossref_metadata_2025_split huggingface dataset:
Vulvar Cancer Incidence in the United States and its Relationship to Human Papillomavirus Vaccinations, 2001–2018
Authors: Berenson Abbey B. , Chang Mihyun , Hawk Ernest T. , Ramondetta Lois M. , Hoang Thao 
Published: August 2022

Abstract

The human papillomavirus (HPV) vaccine was indicated for the prevention of vulvovaginal cancers in 2008, but its impact on the incidence of vulvar cancers within the US is unknown. To determine this, we conducted a secondary analysis of 88,942 vulvar cancer cases among women 20+ years old using the US Cancer Statistics 2001–2018 databases. Data were stratified by tumor behavior (in situ or invasive), age (20–44, 45–64, 65+ years old), race/ethnicity (non-Hispanic White, non-Hispanic Black, Hispanic), and US census region (Northeast, South, Midwest, West), and incidence rates and average annual percentage changes (AAPC) were calculated by group. Reversing previous trends, the incidence of vulvar carcinoma in situ significantly decreased between 2001 and 2018 among women from all age groups, races/ethnicities, and regions (combined AAPC, −4.3; 95% confidence interval (CI), −4.7 to −3.8). The incidence of invasive vulvar squamous cell carcinoma decreased significantly among 20- to 44-year-old women (AAPC, −0.8; 95% CI, −1.3 to −0.3), but significantly increased among those 45 to 64 (AAPC, 2.3; 95% CI, 1.8–2.8) and 65+ years old (AAPC, 1.2; 95% CI, 1.1–1.4). Regardless of tumor behavior, incidence was highest among non-Hispanic Whites and the Midwest region. Overall, the significant declines in vulvar carcinoma in situ among all ages, as well as invasive vulvar cancer among younger women, are encouraging and complement other recent data suggesting HPV vaccinations are already reducing anal and cervical cancer incidence. Over time, further declines in vulvar carcinoma incidence are likely as uptake and completion rates of the HPV vaccine increase in the US.

Prevention Relevance:
We found evidence that HPV vaccinations likely contributed to a decrease in the incidences of vulvar carcinoma in situ and invasive vulvar carcinoma among 20- to 44-year-old women between 2001 and 2018. Our data add to the growing evidence that HPV vaccinations are reducing the incidence of HPV-related anogenital cancers.
Cost-Effectiveness of Catheter Ablation Versus Antiarrhythmic Drug Therapy in Atrial Fibrillation: The CABANA Randomized Clinical Trial
Authors: Chew Derek S. , Li Yanhong , Cowper Patricia A. , Anstrom Kevin J. , Piccini Jonathan P. , Poole Jeanne E. , Daniels Melanie R. , Monahan Kristi H. , Davidson-Ray Linda , Bahnson Tristram D. , Al-Khalidi Hussein R. , Lee Kerry L. , Packer Douglas L. , Mark Daniel B. ,   for the CABANA Investigators
Published: August 2022

Background:
In the CABANA trial (Catheter Ablation vs Antiarrhythmic Drug Therapy for Atrial Fibrillation), catheter ablation did not significantly reduce the primary end point of death, disabling stroke, serious bleeding, or cardiac arrest compared with drug therapy by intention-to-treat, but did improve the quality of life and freedom from atrial fibrillation recurrence. In the heart failure subgroup, ablation improved both survival and quality of life. Cost-effectiveness was a prespecified CABANA secondary end point.

Methods:
Medical resource use data were collected for all CABANA patients (N=2204). Costs for hospital-based care were assigned using prospectively collected bills from US patients (n=1171); physician and medication costs were assigned using the Medicare Fee Schedule and National Average Drug Acquisition Costs, respectively. Extrapolated life expectancies were estimated using age-based survival models. Quality-of-life adjustments were based on EQ-5D–based utilities measured during the trial. The primary outcome was the incremental cost-effectiveness ratio, comparing ablation with drug therapy on the basis of intention-to-treat, and assessed from the US health care sector perspective.

Results:

Costs in the first 3 months averaged $20 794±SD 1069 higher with ablation compared with drug therapy. The cumulative within-trial 5-year cost difference was $19 245 (95% CI, $11 360–$27 170) and the lifetime mean cost difference was $15 516 (95% CI, –$2963 to $35,512) higher with ablation than with drug therapy. The drug therapy arm accrued an average of 12.5 life-years (LYs) and 10.7 quality-adjusted life-years (QALYs). For the ablation arm, the corresponding estimates were 12.6 LYs and 11.0 QALYs. The incremental cost-effectiveness ratio was $57 893 per QALY gained, with 75% of bootstrap replications yielding an incremental cost-effectiveness ratio
<
$100 000 per QALY gained. With no quality-of-life/utility adjustments, the incremental cost-effectiveness ratio was $183 318 per LY gained.

Conclusions:
Catheter ablation of atrial fibrillation was economically attractive compared with drug therapy in the CABANA Trial overall at present benchmarks for health care value in the United States on the basis of projected incremental QALYs but not LYs alone.
Turkish and Soviet Revolutionaries, 1919–22: Cooperation on the Basis of Common Interests
Authors: Demirci Sevtap 
Published: August 2022

Abstract
The wars of the 1910s (Italo-Ottoman, Balkan, First World) gave clear signs that the Ottoman Empire would not last for long faced with the belligerent hostility of the Great Powers and its former subjects. The question was whether or not a consensus could be reached as to its division in accordance with each belligerent’s interests. After Russia’s pulling out of the First World War due to the 1917 Bolshevik Revolution, the new government appeared to be quite enthusiastic to develop friendly relations with the Ottomans first and the Turkish nationalists later, giving them political and financial support throughout the Turkish National Struggle (1919–22). For both sides establishing good relations was of cardinal importance for a variety of reasons that pushed them towards a ‘marriage of convenience’. This article seeks to explain the reasons for this brief Turkish-Bolshevik alliance and why it could not last.
An Analysis of Translation Distance of Tropical Cyclones over the Western North Pacific
Authors: Wang Licheng , Gu Xihui , Gulakhmadov Aminjon , Li Jianfeng , Slater Louise J. , Zhang Qiang , Luo Ming , Ren Guoyu , Kong Dongdong , Lai Yangcheng , Liu Jianyu 
Published: August 2022

Abstract
Tropical cyclone (TC) translation distance, proportional to its duration and translation speed, basically determines the spatial extent of TC-impacted marine and terrestrial areas. Although a long-term slowdown of TCs has recently been reported, changes in translation distance of TCs over the western North Pacific (WNP) and their driving mechanisms remain poorly understood. Using multiple TC datasets, here we find that the trends are opposite in overland translation distance of landfall WNP TCs over China and excluding China, with the number of landfalls in the two groups being almost the same. However, the increase in overland translation distance of landfall TCs over China is offset by a greater decrease in that excluding China, with the result that the overland translation distance of TCs over the WNP has declined (−4.0% decade−1). The oversea translation distance of TCs over the WNP also shows a decreasing trend (−2.4% decade−1), and thus the genesis-to-demise translation distance of TCs over the WNP has significantly decreased (by 17.7%) during 1961–2019. The shorter duration and reduced translation speed of TCs directly and jointly contribute (by 76.9% and 23.1%, respectively) to their shortened translation distance. The gradual increase in westerly and northerly winds and weaker moisture transport during the days following TC generation tend to inhibit long-distance travel after TC genesis. Declining TC translation distance is likely associated with the long-term increases in genesis potential index and an anomalous cyclonic steering flow over the WNP. Our findings suggest that these changes in TC translation distance may alter regional patterns of TC-related drying and wetting of the WNP.

Significance Statement
The spatial extent affected by a tropical cyclone (TC) is largely determined by TC translation distance. For example, TCs passing through marine areas could cool sea surface temperature and modulate local air–sea heat fluxes exchange; TCs with longer translation distances over land are more likely to trigger widespread flooding or terminate droughts in inland areas. Over the western North Pacific (WNP), we find that observational evidence supports opposite trends in overland translation distance of landfall TCs over China and excluding China. Nevertheless, the genesis-to-demise translation distance of TCs shows a significant decline over the WNP during the past six decades. Understanding the impacts of changes in TC translation distance has particular importance given the extensive footprint of TC-related drying and wetting of the marine and terrestrial areas.
The National Hurricane Center Tropical Cyclone Model Guidance Suite
Authors: DeMaria Mark , Franklin James L. , Zelinsky Rachel , Zelinsky David A. , Onderlinde Matthew J. , Knaff John A. , Stevenson Stephanie N. , Kaplan John , Musgrave Kate D. , Chirokova Galina , Sampson Charles R. 
Published: August 2022

Abstract
The National Hurricane Center (NHC) uses a variety of guidance models for its operational tropical cyclone track, intensity, and wind structure forecasts, and as baselines for the evaluation of forecast skill. A set of the simpler models, collectively known as the NHC guidance suite, is maintained by NHC. The models comprising the guidance suite are briefly described and evaluated, with details provided for those that have not been documented previously. Decay-SHIFOR is a modified version of the Statistical Hurricane Intensity Forecast (SHIFOR) model that includes decay over land; this modification improves the SHIFOR forecasts through about 96 h. T-CLIPER, a climatology and persistence model that predicts track and intensity using a trajectory approach, has error characteristics similar to those of CLIPER and D-SHIFOR but can be run to any forecast length. The Trajectory and Beta model (TAB), another trajectory track model, applies a gridpoint spatial filter to smooth winds from the National Centers for Environmental Prediction (NCEP) Global Forecast System (GFS) model. TAB model errors were 10%–15% lower than those of the Beta and Advection model (BAM), the model it replaced in 2017. Optimizing TAB’s vertical weights shows that the lower troposphere’s environmental flow provides a better match to observed tropical cyclone motion than does the upper troposphere’s, and that the optimal steering layer is shallower for higher-latitude and weaker tropical cyclones. The advantages and disadvantages of the D-SHIFOR, T-CLIPER, and TAB models relative to their earlier counterparts are discussed.

Significance Statement
This paper provides a comprehensive summary and evaluation of a set of simpler forecast models used as guidance for NHC’s operational tropical cyclone forecasts, and as baselines for the evaluation of forecast skill; these include newer techniques that extend forecasts to 7 days and beyond.
Gas-Containing Biliary Calculi: Case Series and a Systematic Review
Authors: Huerta Sergio , Kakati Rasha , Lanier Heather 
Published: August 2022

Background Cholelithiasis is a common gallbladder finding leading to cholecystitis in 7% of cases. Sonographic imaging or computed tomography scans are commonly employed for the diagnosis of benign gallbladder disease. Air within the gallbladder might carry various diagnoses. As opposed to pathologic air in the gallbladder seen in emphysematous cholecystitis, gas-containing gallstones are no more pathological than the exclusive presence of gallstones. In the present report, we review the incidence, physiology, typical characteristics, and clinical significance of gas-containing gallstones within the gallbladder. Methods We performed an institutional review of all patients with benign gallbladder disease over the past 16 years (2005 to 2021) to identify patients with gas-containing gallstones in the gallbladder. We performed a review of the literature following the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) to identify all reported cases of patients with gas-containing biliary calculi within the gallbladder. Results Our institutional review identified 5 patients with gas-containing biliary calculi in 1252 consecutive cholecystectomies; 4 of which had cholecystitis, while 1 was an incidental finding. Our review of the literature identified 30 manuscripts documenting 54 unique patients with gas-containing biliary calculi. None of these patients had consequential pathology related to gas in the stones other than that caused by the gallstones (ie, biliary colic and cholecystitis). Conclusions Gas-containing biliary calculi are uncommon. How gas finds itself within gallstones within the gallbladder is not entirely clear. Gas-containing gallstones should not be interpreted as free gas within the gallbladder or within an abscess.
Germ line predisposition variants occur in myelodysplastic syndrome patients of all ages
Authors: Feurstein Simone , Trottier Amy M. , Estrada-Merly Noel , Pozsgai Matthew , McNeely Kelsey , Drazer Michael W. , Ruhle Brian , Sadera Katharine , Koppayi Ashwin L. , Scott Bart L. , Oran Betul , Nishihori Taiga , Agrawal Vaibhav , Saad Ayman , Lindsley R. Coleman , Nakamura Ryotaro , Kim Soyoung , Hu Zhenhuan , Sobecks Ronald , Spellman Stephen , Saber Wael , Godley Lucy A. 
Published: August 2022

Abstract
The frequency of pathogenic/likely pathogenic (P/LP) germ line variants in patients with myelodysplastic syndrome (MDS) diagnosed at age 40 years or less is 15% to 20%. However, there are no comprehensive studies assessing the frequency of such variants across the age spectrum. We performed augmented whole-exome sequencing of peripheral blood samples from 404 patients with MDS and their related donors before allogeneic hematopoietic stem cell transplantation. Single-nucleotide and copy number variants in 233 genes were analyzed and interpreted. Germ line status was established by the presence of a variant in the patient and related donor or for those seen previously only as germ line alleles. We identified P/LP germ line variants in 28 of 404 patients with MDS (7%), present within all age deciles. Patients with P/LP variants were more likely to develop higher-grade MDS than those without (43% vs 25%; P = .04). There was no statistically significant difference in outcome parameters between patients with and without a germ line variant, but the analysis was underpowered. P/LP variants in bone marrow failure syndrome genes were found in 5 patients aged less than 40 years, whereas variants in DDX41 (n = 4), telomere biology disorder genes (n = 2), and general tumor predisposition genes (n = 17) were found in patients aged more than 40 years. If presumed germ line variants were included, the yield of P/LP variants would increase to 11%, and by adding suspicious variants of unknown significance, it would rise further to 12%. The high frequency of P/LP germ line variants in our study supports comprehensive germ line genetic testing for all patients with MDS regardless of their age at diagnosis.
Progression and survival of MBL: a screening study of 10 139 individuals
Authors: Slager Susan L. , Parikh Sameer A. , Achenbach Sara J. , Norman Aaron D. , Rabe Kari G. , Boddicker Nicholas J. , Olson Janet E. , Kleinstern Geffen , Lesnick Connie E. , Call Timothy G. , Cerhan James R. , Vachon Celine M. , Kay Neil E. , Braggio Esteban , Hanson Curtis A. , Shanafelt Tait D. 
Published: August 2022

Abstract
Monoclonal B-cell lymphocytosis (MBL) is a common hematological premalignant condition that is understudied in screening cohorts. MBL can be classified into low-count (LC) and high-count (HC) types based on the size of the B-cell clone. Using the Mayo Clinic Biobank, we screened for MBL and evaluated its association with future hematologic malignancy and overall survival (OS). We had a two-stage study design including discovery and validation cohorts. We screened for MBL using an eight-color flow-cytometry assay. Medical records were abstracted for hematological cancers and death. We used Cox regression to evaluate associations and estimate hazard ratios and 95% confidence intervals (CIs), adjusting for age and sex. We identified 1712 (17%) individuals with MBL (95% LC-MBL), and the median follow-up time for OS was 34.4 months with 621 individuals who died. We did not observe an association with OS among individuals with LC-MBL (P = .78) but did among HC-MBL (hazard ratio, 1.8; 95% CI, 1.1-3.1; P = .03). Among the discovery cohort with a median of 10.0 years follow-up, 31 individuals developed hematological cancers with two-thirds being lymphoid malignancies. MBL was associated with 3.6-fold risk of hematological cancer compared to controls (95% CI, 1.7-7.7; P &lt; .001) and 7.7-fold increased risk for lymphoid malignancies (95% CI:3.1-19.2; P &lt; .001). LC-MBL was associated with 4.3-fold risk of lymphoid malignancies (95% CI, 1.4-12.7; P = .009); HC-MBL had a 74-fold increased risk (95% CI, 22-246; P &lt; .001). In this large screening cohort, we observed similar survival among individuals with and without LC-MBL, yet individuals with LC-MBL have a fourfold increased risk of lymphoid malignancies. Accumulating evidence indicates that there are clinical consequences to LC-MBL, a condition that affects 8 to 10 million adults in the United States.
Multiple datasets to explore the molecular mechanism of sepsis
Authors: Lin Shuang , Luo Bin , Ma Junqi 
Published: August 2022

Abstract
Background
This study aimed to identify potential biomarkers, by means of bioinformatics, affecting the occurrence and development of septic shock.

Methods
Download GSE131761 septic shock data set from NCBI geo database, including 33 control samples and 81 septic shock samples. GSE131761 and sequencing data were used to identify and analyze differentially expressed genes in septic shock patients and normal subjects. In addition, with sequencing data as training set and GSE131761 as validation set, a diagnostic model was established by lasso regression to identify key genes. ROC curve verified the stability of the model. Finally, immune infiltration analysis, enrichment analysis, transcriptional regulation analysis and correlation analysis of key genes were carried out to understand the potential molecular mechanism of key genes affecting septic shock.

Results
A total of 292 differential genes were screened out from the self-test data, 294 differential genes were screened out by GSE131761, Lasso regression was performed on the intersection genes of the two, a diagnostic model was constructed, and 5 genes were identified as biomarkers of septic shock. These 5 genes were SIGLEC10, VSTM1, GYPB, OPTN, and GIMAP7. The five key genes were strongly correlated with immune cells, and the ROC results showed that the five genes had good predictive performance on the occurrence and development of diseases. In addition, the key genes were strongly correlated with immune regulatory genes.

Conclusion
In this study, a series of algorithms were used to identify five key genes that are associated with septic shock, which may become potential candidate targets for septic shock diagnosis and treatment.

Trial registration
Approval number:2019XE0149-1.
SUPPRESSOR OF PHYTOCHROME B-4 #3 reduces the expression of PIF-activated genes and increases expression of growth repressors to regulate hypocotyl elongation in short days
Authors: Jacques Caitlin N. , Favero David S. , Kawamura Ayako , Suzuki Takamasa , Sugimoto Keiko , Neff Michael M. 
Published: August 2022

AbstractSUPPRESSOR OF PHYTOCHROME B-4 #3 (SOB3) is a member of the AT-HOOK MOTIF CONTAINING NUCLEAR LOCALIZED (AHL) family of transcription factors that are involved in light-mediated growth inArabidopsis thaliana, affecting processes such as hypocotyl elongation. The majority of the research on the AHLs has been conducted in continuous light. However, there are unique molecular events that promote growth in short days (SD) compared to constant light conditions. Therefore, we investigated how AHLs affect hypocotyl elongation in SD. Firstly, we observed that AHLs inhibit hypocotyl growth in SD, similar to their effect in constant light. Next, we identified AHL-regulated genes in SD-grown seedlings by performing RNA-seq in twosob3mutants at different time points. Our transcriptomic data indicate thatPHYTOCHROME INTERACTING FACTORS(PIFs)4,5,7, and8along with PIF-target genes are repressed by SOB3 and/or other AHLs. We also identified PIF target genes that are repressed and have not been previously described as AHL-regulated, includingPRE1, PIL1, HFR1,CDF5,andXTR7. Interestingly, our RNA-seq data also suggest that AHLs activate the expression of growth repressors to control hypocotyl elongation, such asHY5andIAA17. Notably, many growth-regulating and other genes identified from the RNA-seq experiment were differentially regulated between these twosob3mutants at the time points tested. Surprisingly, our ChIP-seq data suggest that SOB3 mostly binds to similar genes throughout the day. Collectively, these data suggest that AHLs affect gene expression in a time point-specific manner irrespective of changes in binding to DNA throughout SD.
The impact of specific fracture characteristics of low-energy fractures of the pelvis on mortality
Authors: Ramser Michaela , Vach Werner , Strub Nathalie , Cadosch Dieter , Saxer Franziska , Eckardt Henrik 
Published: August 2022

Abstract
Background
Pelvic fractures in older patients are associated with relevant morbidity and mortality. Both might be determined by fracture morphology and/or patient characteristics. The aim of this project is to investigate the prognostic value of specific fracture characteristics with respect to overall survival and to compare it with an established classification system.

Methods
Retrospective analysis of patients ≥ 60 years, treated conservatively for a CT-scan verified, low-energy pelvic ring fracture between August 2006 and December 2018. Survival data was available from patients’ charts and cantonal or national registries.
The prognostic value of fracture characteristic describing the anterior and posterior involvement of the pelvic ring was investigated. This analysis was repeated after patients were stratified into a high-risk vs a low-risk group according to patient characteristic (age, gender, comorbidities, mobility, living situation). This allowed to assess the impact of the different fracture morphologies on mortality in fit vs. frail senior patients separately.

Results
Overall, 428 patients (83.4% female) with a mean age of 83.7 years were included. Two thirds of patients were still living in their home and mobile without walking aid at baseline. In-hospital mortality was 0.7%, overall, one-year mortality 16.9%. An independent and significant association of age, gender and comorbidities to overall survival was found. Further, the occurrence of a horizontal sacral fracture as well as a ventral comminution or dislocation was associated with an increased mortality. The effect of a horizontal sacral fracture was more accentuated in low-risk patients while the ventral fracture components showed a larger effect on survival in high-risk patients.

Conclusion
Specific fracture characteristics may indicate a higher risk of mortality in conservatively treated patients with a low-energy pelvic ring fracture. Hence, they should be taken into account in future treatment algorithms and decisions on patient management.