bluuebunny/crossref_metadata_2025_split huggingface dataset:
Induction Therapy Followed by Surgery for Unresectable Thymic Epithelial Tumours
Authors: Wang Shuai , Jiang Jiahao , Gao Jian , Chen Gang , Fan Yue , Xu Bei , Dong Jihong , Du Shisuo , Liu Junzhen , Ding Jianyong 
Published: January 2022

Background and ObjectivesThe treatment of unresectable thymic epithelial tumours (TETs) remains controversial. Here, we present the efficacy and safety of induction therapy followed by surgery for unresectable TET.MethodsEighty-one patients with unresectable TETs treated with induction therapy followed by surgery were selected from a retrospective review of consecutive TETs from January 2005 to January 2021. Clinicopathological data were analyzed to assess tumour responses, resectability, adverse events, progression-free survival (PFS) and overall survival (OS).ResultsInduction therapy produced a major tumour response rate of 69.1%, a tumour response grade (TRG) 1-3 rate of 84.0% and an R0 resection rate of 74.1%. The most common toxic effects were all-grade neutropenia (35.8%) and anaemia (34.6%). The 10-year OS and PFS rates were 45.7% and 35.2%. Multivariate analysis showed that ypTNM stage, ypMasaoka stage, complete resection, and TRG were significant independent prognostic factors. Exploratory research revealed that different induction modalities and downstaging of T, N, M, TNM, or Masaoka classifications did not significantly alter the pooled hazard ratio for survival.ConclusionsInduction therapy followed by surgery is well tolerated in patients with unresectable TETs, with encouraging R0 resection rates. Multimodality management provides good control of tumors for unresectable TET patients.
Perioperative Mortality Risk in Patients Undergoing Transoral Robotic Surgery for T1-T2 Oropharyngeal Squamous Cell Carcinoma: A National Cancer Database Study
Authors: Davies Joel C. , Husain Zain , Day Terry A. , Graboyes Evan M. , Eskander Antoine 
Published: January 2022

The National Cancer Database is a joint project of the Commission on Cancer of the American College of Surgeons and the American Cancer Society. The American College of Surgeons and the Commission on Cancer have not verified and are not responsible for the analytic or statistical methods used or for the conclusions drawn from these data by the investigators.IntroductionTransoral robotic surgery (TORS) is well established as initial definitive treatment for early-stage oropharyngeal squamous cell carcinoma (OPSCC) as an alternative to radiation therapy with similar survival rates. While proponents of TORS focus on the reduced morbidity of treatment compared to open procedures, shortened hospital admissions and equivalent survival outcomes to non-surgical treatment, there remain concerns over the risk of mortality within the acute perioperative period. Therefore, we sought to determine the 30-day and 90-day perioperative mortality risk using the National Cancer Database.MethodsA retrospective cohort analysis was performed for patients diagnosed with pathologic T1/2 OPSCC between January 1, 2010, and December 31, 2016 that underwent primary surgical treatment with TORS and was not restricted by HPV status. The primary outcome was 30-day perioperative mortality. The secondary outcome was 90-day perioperative mortality. Univariable analysis was used to identify variables associated with 30-day perioperative mortality.ResultsIn total, 4,127 patients (mean [SD; range] age, 59 [9.5; 22-90] years; 3,476 [84%] men and 651 [16%] women) met inclusion criteria. The number of patients with pT1-2 OPSCC undergoing TORS increased three-fold between 2010 (279/4,127; 7%) to 2016 (852/4,127; 21%). The overall 30-day and 90-day perioperative mortality rate for TORS during the study period was 0.6% (23/4,127) and 0.9% (38/4,127), respectively. On univariable analysis (UVA), age≥65 was the only predictor of 30-day perioperative mortality (OR 3.41; 95% CI 1.49-7.81).ConclusionThe overall risk of all cause mortality following TORS for early-stage OPSCC remains low. The risk of mortality is higher in elderly patients and should be considered, in addition to previously established risk factors, during patient selection and counselling.
Factors Associated With Clinical Responses to Spinal Manipulation in Patients With Non-specific Thoracic Back Pain: A Prospective Cohort Study
Authors: Pasquier Mégane , Young James J. , Lardon Arnaud , Descarreaux Martin 
Published: January 2022

Introduction: The management of musculoskeletal disorders is complex and requires a multidisciplinary approach. Manual therapies, such as spinal manipulative therapy (SMT), are often recommended as an adjunct treatment and appear to have demonstrable effects on pain and short-term disability in several spinal conditions. However, no definitive mechanism that can explain these effects has been identified. Identifying relevant prognostic factors is therefore recommended for people with back pain.Objective: The main purpose of this study was to identify short-term candidate prognostic factors for clinically significant responses in pain, disability and global perceived change (GPC) following a spinal manipulation treatment in patients with non-specific thoracic back pain.Methods: Patients seeking care for thoracic spine pain were invited to participate in the study. Pain levels were recorded at baseline, post-intervention, and 1 week after a single session of SMT. Disability levels were collected at baseline and at 1-week follow-up. GPC was collected post-intervention and at 1-week follow-up. Biomechanical parameters of SMT, expectations for improvement in pain and disability, kinesiophobia, anxiety levels as well as perceived comfort of spinal manipulative therapy were assessed.Analysis: Differences in baseline characteristics were compared between patients categorized as responders or non-responders based on their pain level, disability level, and GPC at each measurement time point. Binary logistic regression was calculated if the statistical significance level of group comparisons (responder vs. non-responders) was equal to, or &lt;0.2 for candidate prognostic factors.Results: 107 patients (62 females and 45 males) were recruited. Mean peak force averaged 450.8 N with a mean thrust duration of 134.9 ms. Post-intervention, comfort was associated with pain responder status (p &lt; 0.05) and GPC responder status (p &lt; 0.05), while expectation of disability improvement was associated with GPC responder status (p &lt; 0.05). At follow-up, comfort and expectation of pain improvement were associated with responder GPC status (p &lt; 0.05). No association was found between responder pain, disability or GPC status and biomechanical parameters of SMT at any time point.Discussion: No specific dosage of SMT was associated with short-term clinical responses to treatment. However, expectations of improvement and patient comfort during SMT were associated with a positive response to treatment.
Protectin DX Attenuates Lumbar Radicular Pain of Non-compressive Disc Herniation by Autophagy Flux Stimulation via Adenosine Monophosphate-Activated Protein Kinase Signaling
Authors: Zhao Qing-xiang , Wang Yi-hao , Wang Si-cong , Xue Song , Cao Zhen-xin , Sun Tao 
Published: January 2022

Background: Neuroinflammation plays a crucial role in initiating and sustaining lumbar radicular pain (LRP). Protectin DX (PDX) has been experimentally verified to possess pro-resolving properties and anti-inflammatory effects. This study aimed to observe the analgesic effects of PDX and its potential mechanisms in LRP rats with non-compressive lumbar disc herniation (NCLDH).Method: Only male rats were selected to avoid gender-related interferences. Rat models of NCLDH were established, and rats were randomly divided into four groups: the sham group, the vehicle group, the PDX (10 ng PDX) group, and the PDX (100 ng PDX) group. Changes in the mechanical withdrawal threshold and thermal withdrawal latency were observed for 7 days. The mRNAs of pro-inflammatory and anti-inflammatory mediators were evaluated via real-time polymerase chain reaction, whereas western blot and immunohistochemistry were separately conducted to assess the expression levels of autophagy-related proteins and adenosine monophosphate-activated protein kinase (AMPK) signaling.Results: Intrathecal delivery of PDX reduced interleukin (IL)-6 and IL-1β mRNA levels and facilitated mRNA transcription of transforming growth factor-β1, with attenuation of mechanical and thermal hyperalgesia in LRP rat models. With the application of nucleus pulposus to the dorsal root ganglion, autophagy flux and AMPK signaling were severely disrupted in the spinal dorsal horns, and intrathecal treatment with PDX could dose-dependently restore the dysfunction of autophagy flux and AMPK signaling.Conclusion: These data suggest that PDX possesses pro-resolving properties and exerts potent analgesic effects in LRP by affecting autophagy flux via AMPK signaling.
Effects of the DRD4 −521 C/T SNP on Local Neural Activity and Functional Connectivity in Children With ADHD
Authors: Zhang Huan , Yang Binrang , Peng Gang , Zhang Linlin , Fang Diangang 
Published: January 2022

Objective: The present study aimed to investigate the effects of the dopamine receptor D4 (DRD4) −521 C/T single-nucleotide polymorphism on brain function among children with attention deficit hyperactivity disorder (ADHD) and to evaluate whether brain function is associated with behavioral performance among this demographic.Methods: Using regional homogeneity, fractional amplitude low-frequency fluctuation, and functional connectivity as measurement indices, we compared differences in resting-state brain function between 34 boys with ADHD in the TT homozygous group and 37 boys with ADHD in the C-allele carrier group. The Conners' Parent Rating Scale, the SNAP-IV Rating Scale, the Stroop Color Word Test, the go/no-go task, the n-back task, and the working memory index within the Wechsler Intelligence Scale for Children-Fourth Edition were selected as comparative indicators in order to test effects on behavioral performance.Results: We found that TT homozygotes had low behavioral performance as compared with C-allele carriers. The regional homogeneity for TT homozygotes decreased in the right middle occipital gyrus and increased in the right superior frontal gyrus as compared with C-allele carriers. In addition, the right middle occipital gyrus and the right superior frontal gyrus were used as the seeds of functional connectivity, and we found that the functional connectivity between the right middle occipital gyrus and the right cerebellum decreased, as did the functional connectivity between the right superior frontal gyrus and the angular gyrus. No statistically significant differences were observed in the respective brain regions when comparing the fractional amplitudes for low-frequency fluctuation between the two groups. Correlation analyses demonstrated that the fractional amplitude low-frequency fluctuation in the precentral gyrus for TT homozygotes were statistically significantly correlated with working memory.Conclusions: We found differing effects of DRD4 −521 C/T polymorphisms on brain function among boys with ADHD. These findings promote our understanding of the genetic basis for neurobiological differences observed among children with ADHD, but they must be confirmed in larger samples.
The Construction and Development of a Clinical Prediction Model to Assess Lymph Node Metastases in Osteosarcoma
Authors: Li Wenle , Dong Shengtao , Wang Bing , Wang Haosheng , Xu Chan , Zhang Kai , Li Wanying , Hu Zhaohui , Li Xiaoping , Liu Qiang , Wu Rilige , Yin Chengliang 
Published: January 2022

Background: This study aimed to construct a clinical prediction model for osteosarcoma patients to evaluate the influence factors for the occurrence of lymph node metastasis (LNM).Methods: In our retrospective study, a total of 1,256 patients diagnosed with chondrosarcoma were enrolled from the SEER (Surveillance, Epidemiology, and End Results) database (training cohort, n = 1,144) and multicenter dataset (validation cohort, n = 112). Both the univariate and multivariable logistic regression analysis were performed to identify the potential risk factors of LNM in osteosarcoma patients. According to the results of multivariable logistic regression analysis, A nomogram were established and the predictive ability was assessed by calibration plots, receiver operating characteristics (ROCs) curve, and decision curve analysis (DCA). Moreover, Kaplan-Meier plot of overall survival (OS) was plot and a web calculator visualized the nomogram.Results: Five independent risk factors [chemotherapy, surgery, lung metastases, lymphatic metastases (M-stage) and tumor size (T-stage)] were identified by multivariable logistic regression analysis. What's more, calibration plots displayed great power both in training and validation group. DCA presented great clinical utility. ROCs curve provided the predictive ability in the training cohort (AUC = 0.805) and the validation cohort (AUC = 0.808). Moreover, patients in LNN group had significantly better survival than that in LNP group both in training and validation group.Conclusion: In this study, we constructed and developed a nomogram with risk factors, which performed well in predicting risk factors of LNM in osteosarcoma patients. It may give a guide for surgeons and oncologists to optimize individual treatment and make a better clinical decision.
The Influence of Prophylactic Calcium and Magnesium Supplementation on Postoperative Quality of Life and Hypocalcemia After Total Thyroidectomy: Study Protocol for a Randomized Controlled Trial
Authors: Tabriz Navid , Fried Dennis , Uslar Verena , Weyhe Dirk 
Published: January 2022

Background: We want to investigate if a routine preoperative dietary supplementation of calcium and magnesium prior to thyroidectomy for nodular goiter and graves' disease can influence patients' outcome with regards to hypocalcemia associated symptoms and quality of life in order to reduce the risk of post-thyroidectomy hypocalcemia and to improve patient's quality of life.Methods: The study will be conducted as a two-armed randomized controlled trial including patients scheduled for total thyroidectomy. Patients assigned to the intervention group will receive calcium carbonate and magnesium oxide starting 2 weeks preoperatively. Primary outcome is the postoperative quality of life measured by the ThyPRO-39 and EQ-5D questionnaires. Secondary outcome is the assessment of postoperative biochemical (calcium and PTH levels) and clinical hypocalcemia (symptoms as reported by the patient).Discussion: A prophylactic dietary supplementation with calcium and magnesium, which could easily be implemented in the preoperative setting, could potentially help to avoid or reduce hypocalcemia-associated symptoms and improve quality of life. In the event of a positive outcome, this preoperative procedure can be an inexpensive way to prepare patients scheduled for thyroidectomy and can possibly reduce disease-specific costs by reducing the postoperative complication rate.Clinical Trial Registration: DRKS00017195 in the German clinical trials register (Deutsches Register Klinischer Studien, DRKS) on the 22.05.2019.
LIM-Domain-Binding Protein 1 Mediates Cell Proliferation and Drug Resistance in Colorectal Cancer
Authors: Zhu Mo , Jiang Baofei , Zuo Hao , Wang Xiaopeng , Ge Hengfa , Huang Ziming 
Published: January 2022

Objective: It has been shown that LIM-domain-binding protein 1 (LDB1) is involved in the tumorigenesis of several cancers, but its function in colorectal cancer (CRC) has not been fully explained. This study is aimed to investigate whether LDB1 is involved in regulating the cell growth and drug sensitivity of CRC.Methods: To analyze the protein expression of LDB1 in CRC tissues, western blot was used. KM plotter and UALCAN databases were used to predict the prognosis of CRC patients with low or high LDB1 expression. To do the correlation analysis in CRC tissues, GEPIA database was used. CCK-8 assay and xenograft models were used to evaluate the effects of LDB1 in CRC cell growth. An oxaliplatin-resistant cell line was constructed to evaluate the effect of LDB1 in drug sensitivity of CRC cells.Results: Our current research confirmed that LDB1 was upregulated in CRC tumor tissues, and its elevation predicted a poor prognosis for CRC patients. LDB1 was also found positively correlated with CCNA1, BCL2 and BCLW, but negatively correlated with the pro-apoptotic signals (BID, BAX and BAK). Silence of LDB1 significantly inhibited CRC cell growth in vitro, and CRC cells with low expression of LDB1 had a lower tumorigenesis rate in tumor-bearing nude mice. Our experiments also showed that LDB1 silence enhanced the anti-tumor activity of oxaliplatin in CRC cells. The expression of LDB1 was also found increased in oxaliplatin-resistant CRC cell lines, and silence of LDB1 partly restored the antitumor effect of oxaliplatin in an oxaliplatin-resistant CRC cell line.Conclusion: Our current results revealed the roles of LDB1 in the growth and drug resistance of CRC cells, and may provide the new theoretical support for LDB1 as a potential target for the treatment of CRC in the future.
PENDAMPINGAN BELAJAR SISWA DENGAN PEMBELAJARAN MATEMATIKA REASLITIK DALAM MENINGKATKAN SEMANGAT BELAJAR SISWA
Authors: Sulistyowati Sulistyowati , Zulfa Fariha Amalia 
Published: January 2022

ABSTRAKPengabdian masyarakat yang dilakukan KKN DR IAIN Kediri 2021 yaitu berupa pendampingan belajar siswa di Kelurahan Kaliombo, Kecamatan Kota, Kota Kediri. Pengabdian masyarakat ini bertujuan untuk meningkatkan semangat dan antusias siswa untuk belajar khususnya pada mata pelajaran matematika di masa pandemic covid 19. Kegiatan pemdampingan belajar ini langsung dipraktekkan dengan mengajar di kelas lalu menggunakan metode yang sudah disiapkan dan dirancang yaitu metode pembelajaran matematika realistik. Hasil dari kegiatan ini memiliki respon dari peserta didik sangat baik dan antusias untuk mengikuti bimbingan belajar dari awal hingga akhir pelaksanaan pendampingan belajar, sehingga dapat meningkatkan semangat dan antusias siswa. ABSTRACTCommunity service carried out by KKN DR IAIN Kediri 2021 is in the form of student learning assistance in the Kaliombo Village, City District, Kediri City. This community service aims to increase the enthusiasm and enthusiasm of students to learn, especially in mathematics subjects during the covid 19 pandemic. This learning mentoring activity is directly practiced by teaching in class and then using methods that have been prepared and designed, namely realistic mathematics learning methods. The results of this activity have responses from students who are very good and enthusiastic to participate in tutoring from the beginning to the end of the implementation of learning assistance, so as to increase the enthusiasm and enthusiasm of students.
Pengetahuan Tentang Corona Virus – 19 Terhadap Perilaku Pencegahan Pada Remaja
Authors: Dian Soekmawaty Riezqy Ariendha  , Irni Setyawati  , Kusniyati Utami  
Published: January 2022

Badan Kesehatan Dunia (WHO) dan otoritas besar lainnya merekomendasikan beberapa upaya pencegahan covid, terutama mencuci tangan dan menggunakan masker, serta menerapkan prosedur kebersihan tangan yang tepat sebagai salah satu cara termudah, dan terpenting menjaga untuk mencegahpenyebaran virus. Untuk remaja sangat penting untuk menjadi kebiasaan mereka untuk melakukan pencegahan penyebaran virus. Beberapa pengetahuan tentang Covid-19, merupakan upaya pencegahan covid baik dari pemerintah Indonesia maupun WHO. Tujuan penelitian ini adalah untuk mengetahui apakah pengetahuan tentang Covid-19 berhubungan dengan perilaku cuci tangan, dan penggunaan masker dalam upaya pencegahan covid-19 pada remaja. Metode penelitian ini menggunakan metode cross sectional. Penelitian dan pengumpulan data ini dilakukan di STIKes Yarsi Mataram yaitu pada mahasiswa Prodi D3 Kebidanan dan S1 Kebidanan Stikes Yarsi Mataram. Pengumpulan data menggunakan kuesioner google form yaitu kuesioner berbasis dataonlineyang disebarkan melalui Whatsapp. Kuesioner terkumpul sebanyak 111 orang. Hasil penelitian ini Dari uji statistik didapatkan nilai p<0,05, dimana nilai p=0,028. Terdapat hubungan cuci tangan berdasarkan pengetahuan tentang covid-19 dan dari uji statistik didapatkan nilai p<0,05, dimana nilai p=0,013. Terdapat hubungan penggunaan masker berdasarkan pengetahuan tentang covid-19. Dapat disimpulkan semakin baik informasi yang didapatkan, semakin baik pula perilaku cuci tangan dan penggunaan masker untuk pencegahan covid-19.
Hubungan Pendidikan, Paritas dan Dukungan KAder dengan Deteksi Dini Kanker Serviks Pada Pemeriksaan IVA di Puskesmas Nagaswidak Palembang Tahun 2021
Authors: Marina Yanti  , Eka Rahmawati  , Putu Lusita  , Tuti Farida  
Published: January 2022

Kanker serviks dan payudara merupakan penyebab kematian cukup tinggi pada perempuan, umumnya wanita usia produktif mulai dari 30-50 tahun. Tujuan penelitian ini adalah untuk mengetahui hubungan pendidikan, paritas dan dukungan kader secara simultan dengan deteksi dini kanker serviks pada pemeriksaan IVA Di Puskesmas Nagaswidak Palembang Tahun 2021. Desain penelitian ini menggunakan metode survey analitik dengan pendekatan cross sectional. Populasi berjumlah 84 responden dan jumlah sampel dalam penelitian ini adalah sebanyak 84 responden. Pengambilan sampel penelitian dengan menggunakan Jumlah sampling. Pengumpulan data dengan menggunakan data primer dan sekunder. Hasil penelitian analisis univariat responden yang mengalami Deteksi Dini Kanker Serviks berjumlah 59 orang (70.2%), Pendidikan tinggi berjumlah 46 orang (54.8%), paritas tidak berisiko 50 orang (59.5%), Dukungan Kader berjumlah 56 orang (66.7%). Hasil analisis bivariat ada hubungan bermakna antara pendidikan terhadap deteksi dini kanker serviks dengan nilai p value sebesar 0,000 < 0,05, paritas terhadap deteksi dini kanker serviks dengan nilai p value sebesar 0,033 < 0,05, dan dukungan kader terhadap terdeteksi dini kanker serviks dengan nilai p value sebesar 0,002 < 0,05 secara simultan dengan kejadian deteksi dini kanker serviks pada pemeriksaan IVA Di Puskesmas Nagaswidak Palembang Tahun 2021. Kesimpulan penelitian ini adalah ada hubungan pendidikan, paritas dan dukungan kader secara simultan dengan deteksi dini kanker serviks pada pemeriksaan IVA Di Puskesmas Nagaswidak Palembang Tahun 2021. Adapun saran bagi petugas kesehatan hasil penelitian ini diharapkan agar petugas kesehatan di Puskesmas Nagaswidak Palembang, dapat dengan siaga memberikan informasi dan edukasi kepada wanita usia subur terkait kesehatannya khususnya kesehatan reproduksi.