bluuebunny/crossref_metadata_2025_split huggingface dataset:
SafeguardingDrosophilafemale germ cell identity depends on an H3K9me3 mini domain guided by a ZAD zinc finger protein
Authors: Shapiro-Kulnane Laura , Selengut Micah , Salz Helen K. 
Published: September 2022

AbstractH3K9me3-based gene silencing is a conserved strategy for securing cell fate, but the mechanisms controlling lineage-specific installation of this epigenetic mark remain unclear. InDrosophila, H3K9 methylation plays an essential role in securing female germ cell fate by silencing lineage inappropriatephf7transcription. Thus,phf7regulation in the female germline provides a powerful system to dissect the molecular mechanism underlying H3K9me3 deposition onto protein coding genes. Here we used genetic studies to identify the essential cis-regulatory elements, finding that the sequences required for H3K9me3 deposition are conserved acrossDrosophilaspecies. Transposable elements are also silenced by an H3K9me3-mediated mechanism. But our finding thatphf7regulation does not require the dedicated piRNA pathway components,piwi, aub, rhino, panx, andnxf2, indicates that the mechanisms of H3K9me3 recruitment are distinct. Lastly, we discovered that an uncharacterized member of the zinc finger associated domain (ZAD) containing C2H2 zinc finger protein family, IDENTITY CRISIS (IDC; CG4936), is necessary for H3K9me3 deposition ontophf7. Loss ofidcin germ cells interferes withphf7transcriptional regulation and H3K9me3 deposition, resulting in ectopic PHF7 protein expression. IDC’s role is likely to be direct, as it localizes to a conserved domain within thephf7gene. Collectively, our findings support a model in which IDC guides sequence-specific establishment of an H3K9me3 mini domain, thereby preventing accidental female-to-male programming.Author SummaryTissue development and function relies on cells remembering their identity. A cell’s identity is defined by the genes it expresses and those it does not. Recent work has shown that genes can be silenced by trimethylation of histone H3 lysine 9 (H3K9me3) marked chromatin, and that H3K9me3-mediated gene silencing is a vital strategy for securing cell fate. But there is very little information about how the machinery responsible for H3K9 methylation finds its target genes. Here we explore this issue using theDrosophilafemale germline where a mini domain of repressive H3K9me3 chromatin secures female germ cell fate by silencingphf7, a gene normally expressed in male germ cells. Transposable elements are also silenced by H3K9me3 mini domains, but we find that the proteins involved in this process are not required forphf7silencing. Instead, we find that silencing requires a previously uncharacterized protein, we have named IDENTITY CRISIS. Our work provides evidence that IDENTITY CRISIS directs the H3K9 methylation machinery to build a mini domain at thephf7locus. Our results shed new light into how cells safeguard their identity by silencing cell type inappropriate genes, and more specifically how these genes are identified by the silencing machinery.
Institutional isomorphism and adoption of building information modelling (BIM) in small and medium-sized enterprises (SMEs) of the Nigerian Construction Industry
Authors: Saka Abdullahi B. , Chan Daniel W.M. , Ajayi Saheed O. 
Published: September 2022

PurposeAlthough there has been a surge in the adoption of building information modelling (BIM) in the construction industry, the small and medium-sized enterprises (SMEs) are still struggling and perceive its adoption as risky. The SMEs in developing economies are especially on the disadvantaged side of the digital divide. Extant studies have focused on large firms and there are scanty studies on the influence of the external environments on BIM adoption in SMEs. Thus, this study espouses institutional theory (INT) to examine the influence of coercive, mimetic, and normative pressures on BIM awareness and adoption in SMEs.Design/methodology/approachA quantitative approach was employed, and data were collected from the Nigerian construction SMEs via an empirical questionnaire survey using a sequential stratified and convenient sampling method. Hypothesized relationships between the coercive, mimetic, and normative pressure and BIM in SMEs were empirically tested using the partial least squares structural equation modelling (PLS-SEM) technique and the model was validated with the “PLSpredict” procedure.FindingsThe results revealed that coercive and mimetic pressures significantly influence BIM adoption in SMEs while normative pressures have the strongest influence on BIM in SMEs. Also, BIM awareness is an important predictor of BIM adoption. The findings also shed light on the influence of firmographics on BIM awareness and adoption in Nigerian SMEs.Originality/valueThe study empirically validates the applicability of INT and highlights that BIM adoption is not only influenced by internal responses to the need for efficiency but also by external pressures. It implies a clear need for intentional isomorphic pressures in driving BIM adoption in SMEs. The study employs the INT to explain a phenomenon that has not been theoretically explored in the context of SMEs in developing economies. Lastly, the study provided valuable insights into driving BIM adoption, together with the effective practical implications for implementation and potential research areas for further studies.
A critical study of the existing issues in circular economy practices during movement control order: can BIM fill the gap?
Authors: Ismail Zul-Atfi Bin 
Published: September 2022

PurposeThe improper evaluation and information management of circular economy (CE) (i.e. design, planning, supply chain, waste pile and material hazard) is critical for public health and is a major problem in the waste management of precast concrete (PC) building manufacture and construction and demolition wastes industry. The CE model is particularly problematic for PC building construction projects where the standard practices for the total number of waste building materials are not appropriate and do not match the safe disposal design specification, such as the recent number increase in the Malaysian illegal construction waste pile during the Movement Control Order (11 March 2021, about 5 out of 29 landfills related to states enforcing Act 672). The study aims to develop a framework application (i.e. Building Information Modelling [BIM]) that supports intelligent waste recycling management and sophisticated CE model system solutions.Design/methodology/approachThus, the development of a new BIM-based programming algorithm approach is proposed for optimising CE in accordance with the needs of the current PC building construction schemes. As a precursor to this study, the concepts of CE practices are reviewed and the main features of BIM tools and techniques currently being employed on such projects are presented.FindingsSophisticated CE system solutions are described as an essential component of this optimisation to reduce the amount of waste generated at the end of the life cycle of PC building construction projects and to better manage the resources used throughout it.Originality/valueFinally, the potential for a research framework for developing such a system in the future is presented.
Diversity skills for future teachers: how transformative learning prepares pre-service teachers for diversity in Austrian schools
Authors: Resch Katharina 
Published: September 2022

PurposeMezirow's theory of transformative learning aims to evoke change on a deeper level of learning. This qualitative study with 38 pre-service teachers enrolled in a Master's degree programme for teacher education in Austria used semi-structured interviews to explore how diversity skills can transform after diversity training applying Mezirow's theory of transformative learning. In these trainings, a disorienting dilemma was placed at the centre of the diversity training from which transformative learning took its start.Design/methodology/approachIn an increasingly diversified school system, diversity skills have become a pedagogical necessity for teachers in their future workplace. However, many teachers state not feeling adequately prepared for diversity within higher education and their attitudes towards diversity oftentimes remain unchanged despite diversity training.FindingsThe findings were deduced from structured content analysis. They show that the diversity trainings led to new cultural frames of reference for the study participants on a cognitive and social level, but to a smaller extent on an emotional level.Originality/valueThe study follows a different approach than “typical” diversity trainings through Mezirow's theory on transformative learning contributing to making a real change to preparing students for their workplaces in diversified Austrian schools.
Intention to use Internet of Things (IoT) in higher education online learning – the effect of technology readiness
Authors: Negm Eiman 
Published: September 2022

PurposeThis study examines higher education students' technology readiness level in explaining adoption intention toward educational Internet of Things (IoT) needed for online learning.Design/methodology/approachQuantitative deductive research approach is used to check the theory of technology readiness index toward IoT in education. An online administrated questionnaire is distributed through convenience sampling to reach generation(Z) students. The questionnaire is developed using Google form, placing the link on various universities' social media platforms so to be accessible to the respondents. Path coefficient analysis of SEM is used to test the hypotheses.FindingsResults show that the individual's level of technological optimism, discomfort and insecurity impact adoption intentions toward IoT products and services for online learning; the mental motivator, innovativeness, is insignificant.Practical implicationsThis study helps guide practitioners (education institutions, IoT-developers, marketers and other professionals in the field) to consider students' mindset when designing products and strategies for promoting online learning and introducing educational IoT. This research provides insights on IoT in higher education; it provides perspectives for IoT adoption intention pro-online learning, aiding institutions looking for trends and practices for skills and work-based learning developments.Originality/valueThis study contributes to knowledge and literature by shedding light on the educational challenge of why not all students could harness the potentials of online learning and IoT of the twenty-first century. It provides insights to clarify students' mindset toward educational IoT needed for online learning.
Organisational resilience: the role of organisational culture from an organisational life cycle perspective
Authors: Su Sophia , Baird Kevin , Munir Rahat 
Published: September 2022

PurposeThis study examines the influence of organisational culture on organisational resilience from an organisational life cycle (OLC) perspective.Design/methodology/approachAn online survey questionnaire was used to collect data from 410 middle-level managers in Australian business organisations using Qualtrics, a well-known international data collection organisation.FindingsThe findings reveal that the respect for people/teamwork cultural dimension is positively associated with organisational resilience across all OLC stages (i.e. birth, growth, maturity and revival stages). In addition, the outcome-oriented (innovation) culture dimension enhance organisational resilience in the growth and revival (maturity) stages.Originality/valueThe findings contribute to the limited literature by providing empirical evidence on how specific organisational cultural dimensions can enhance organisational resilience across different development stages of organisations (i.e. the birth, growth, maturity and revival stages).
Mind the queue: understanding challenges of introducing e-government policies for entrepreneurs during Covid-19 in a Latin American country
Authors: Discua Cruz Allan , Reyes Hernandez Jose Mario , Arias Arévalo Carlos Roberto 
Published: September 2022

PurposeThis study aims to focus on understanding the tensions experienced by government officials in introducing electronic government (e-government) policies to support entrepreneurs in a developing Latin American country.Design/methodology/approachThis study relies on an in-depth qualitative approach based on collaborative and analytic auto-ethnography. The authors concentrate on tensions experienced by a government official and how they were addressed when introducing e-government policies to support entrepreneurs during the Covid-19 pandemic.FindingsThe findings reveal that paradoxical tensions occur as changes are demanded, multiple concerns are expressed and decisions about resources have to be made. The findings reveal sources of tensions from government, business and external sources. Addressing such tensions revolves around a diverse form of paradoxes dealing with contradictions in terms of speed vs thoroughness and short- vs long-term implications.Research limitations/implicationsThe authors’ study provides several contributions. It advances understanding on the source and management of tensions experienced by government officials introducing e-government policies to support entrepreneurs during the Covid-19 pandemic. It also delineates multiple paradoxes experienced by government officials as new policies and systems were introduced. Finally, it offers a conceptual model explaining how government officials deal with multiple tensions emerging from the introduction of e-government policies in a developing country.Originality/valueThe prior literature has suggested that e-government initiatives would be guided by a prescriptive and tension-free process, driven by the interest to enhance governmental efficiency. This study reveals that developing e-government initiatives for entrepreneurs and existing businesses during the Covid-19 crisis was not immune to contradictions between government officials and the public. A conceptual model, based on multiple sources of tensions (government-related, business-related and external sources) and their management, is proposed. Implications and opportunities for further research are presented.
Profiling a niche actor of civil society diplomacy: the unattached diplomat
Authors: Anton Anca 
Published: September 2022

PurposeThe purpose of this study is to define the communicational profile of unattached diplomats and explore the viability of state-centric concepts such as citizen diplomacy when discussing non-state actors emerging from civil society.Design/methodology/approachThe paper uses a comparative, multiple case design focusing on descriptive case studies (Yin, 2018) that explore the diplomatic endeavours and social biographies of “citizens of the world” acting at a global or local level, not explicitly attached to or explicitly against an official, state agenda: Malala Yousafzai, Greta Thunberg and Bill Gates.FindingsThe unattached diplomats have organisational mobility but are attached to the cause they promote, a configuration that fundamentally opposes that of the traditional or organisational diplomat. Looking at individuals from a diplomatic perspective, not as instruments or as targets, but rather as agents with their own agenda, issues and diplomatic capital, the unattached diplomats define their lack of attachment through organisational mobility, adversarial positioning or personal financial autonomy with regard to state diplomatic institutions or for-profit/not-for-profit organisations.Research limitations/implicationsA higher number and diversity of case studies can enable the identification of patterns and standards.Originality/valueThis study introduces and operationalises the concept of unattached diplomats. To the best of the author’s knowledge, this study is the first to discuss it in the context of another emerging concept, currently insufficiently researched: civil society diplomacy.
On the two conceptualizations of information experience as an object of study: a response to Yu and Liu
Authors: Gorichanaz Tim 
Published: September 2022

PurposeThe purpose of this paper is to further the scholarly discussion of information experience as an object of study, including how this research area fits into library and information studies more broadly.Design/methodology/approachA conceptual discussion of certain issues raised in Yu and Liu's recent paper in this journal.FindingsWhile Yu and Liu seem to suggest that only a priori information experience research belong in library and information science (LIS), this paper suggests that a priori and a posteriori research have a synergistic relationship and both have a home in LIS.Originality/valueThis paper clarifies how the two conceptualizations of information experience as an object of study relate to each other, as well as how these relate to information experience as a research approach, and how all this fits within the metadisciplinary field of LIS.
The impact of halal tourism on Muslim diaspora intention to recommend: an application of the theory of planned behaviour
Authors: Mohammed Iddrisu , Mahmoud Mahmoud Abdulai , Preko Alexander , Hinson Robert , Yeboah Joseph G. 
Published: September 2022

PurposeThis paper sought to examine the factors that influence intention to recommend, focussing on the extension of the theory of planned behaviour in halal tourism, with additional instruments such as halal safety and security, and trustworthiness of halal information.Design/methodology/approachGuided by a quantitative approach, cross-sectional data were collected using 394 Muslim diaspora tourists. The analysis technique used in this study is the partial least square structural equation modelling (PLS-SEM).FindingsThe results suggest that halal planned behaviour may account for the intention to recommend. Halal attitude, subjective norm, halal image, halal value, halal safety and security, and trustworthiness of halal information positively and significantly affect intention to recommend.Practical implicationsMuslim diaspora tourists are identified to have halal planned behaviour on intention to recommend. Hence, destination managers and practitioners are suggested to develop proactive halal products and services that appeal to tourists' intention to recommend.Originality/valueThis study has developed two new constructs: halal safety and security, and the trustworthiness of halal information grounded on the theory of planned behaviour in halal tourism. Specifically, the focus is on Muslim diasporic tourists' perspective in a non-Islamic context.
Human-centered integrated care pathways for co-creating a digital, user-centric health information solution
Authors: Turk Eva , Wontor Viola , Vera-Muñoz Cecilia , Comnes Lucia , Rodrigues Natercia , Ferrari Giovanna , Moen Anne 
Published: September 2022

PurposeA broader challenge of co-creating digital solutions with patients addresses the question how to apply an open-access digital platform with trusted digital health information as a measure to transform the way patients access and understand health information. It further addresses use this for adherence to treatment, risk minimization and quality of life throughout the integrated patient journey. The aim of this paper is to demonstrate the early steps in towards progress to co-creating the digital solution.Design/methodology/approachTo coordinate the co-creation process, the authors established a multiphased plan to deep-dive into user needs and behaviors across patient journeys, to identify nuances and highlight important patterns in stakeholder and end-user segment at various stages in the patient's journey.FindingsA set of tools was designed to serve as a human-centered compass throughout the lifecycle of the project. Those tools include shared objects; personas, user journeys, a set of performance indicators with related requirements – all those tools being consistently refined in ongoing co-creation workshops with members of the cross-functional stakeholder groups.Originality/valueIn this study, a multidisciplinary, public-private partnership looked at integrated digital tool to improve access, understanding and adherence to treatment for diverse groups of patients across all stages of their health journeys in a number of countries including European Union (EU) and United States of America (USA). As a result of this work, the authors attempt to increase the possibility that the improved availability and understanding of health information from trusted sources translates to higher levels of adherence to treatment, safer use of medication (pharmacovigilance), better health outcomes and quality of life integrated in the patient's journey.
Patterns of behavioural preferences in innovation and project activities
Authors: Litau Ekaterina Yakovlevna 
Published: September 2022

PurposeIn today’s world, high-quality economic development is possible through innovative entrepreneurial activity, which has led to the creation of various kinds of innovation infrastructure facilities that support future high-tech projects. However, the system of selecting start-ups to populate and produce for such organisations does not take into account several factors that exert strong influence on the success of an innovative entrepreneurial project. In this article, the author presents the developed multi-factor methodology of project scoring, which is recommended for use both at the initial stage and in the process of development and implementation of innovative idea.Design/methodology/approachThe suggested multi-factor methodology is both a qualitative and quantitative methodology that allows evaluation of proposed projects by taking into account individual goals of the innovation infrastructure, serving as a flexible tool for analysing project potential and taking into account the model of human behavioural preferences as a key driver of economic activities.Findings As a result of the first (qualitative) stage of the study, the author confirmed the hypothesis that the theoretical model of behavioural preferences corresponds to the demonstrated behavioural characteristics of reference respondents. As a result of the second (quantitative) phase of the research, the author conducted a survey of business incubator residents claiming one of the four models of behavioural preferences, followed by quantitative analysis to determine the extent to which the demonstrated behavioural traits of the respondents correspond to those presented in the theoretical model. The results of the second stage of the study were used in the final scoring of start-ups to identify the most promising projects in terms of development.Originality/value The project scoring methodology was tested in two of the largest business incubators in St. Petersburg and clearly demonstrated that the use of qualitative indicators significantly increases the ability of incubator experts to make decisions regarding incoming project information.