bluuebunny/crossref_metadata_2025_split huggingface dataset:
PrEP stigma among current and non-current PrEP users in Thailand: A comparison between hospital and key population-led health service settings
Authors: Chautrakarn Sineenart , Rayanakorn Ajaree , Intawong Kannikar , Chariyalertsak Chonlisa , Khemngern Porntip , Stonington Scott , Chariyalertsak Suwat 
Published: December 2022

BackgroundPre-exposure prophylaxis (PrEP) has demonstrated effectiveness in high-risk populations. PrEP service in Thailand became free of charge under the Universal Health Coverage (UHC) in 2021. The National Health Security Office launched a pilot project in 2020 to ensure sustainable service delivery, and the national monitoring and evaluation (M&amp;E) framework was adopted to evaluate early phase implementation. We carried out a cross-sectional survey as part of the M&amp;E process to investigate PrEP stigma among current and non-current PrEP users from both hospital and Key Population Led Health Services (KPLHS) settings in Thailand.MethodsBetween August and October 2020, an online cross-sectional survey was conducted. A link for a self-administered questionnaire was distributed to all active PrEP centers and PrEP clients were then recruited by PrEP providers. Descriptive and univariate analysis using Chi-square were applied in the analyses. Attitudes toward PrEP were ranked from the most negative to the most positive. The negative attitude can be interpreted as PrEP stigma.ResultsThis study included 513 PrEP clients (355 from hospitals and 158 from KPLHS). In both settings, respondents' attitudes toward PrEP were generally positive, but some potential stigma was observed. 31.8% of hospital PrEP clients and 9.5% of KPLHS clients agreed that PrEP users should keep their pills hidden from others. Almost half (44.5%) of hospital clients and 18.4% of KPLHS clients agreed that PrEP users are often viewed negatively by society. More than 20% of hospital clients and 12% of KPLHS agreed that PrEP users frequently experience difficulties when their partner/lover/family find out that he or she is on PrEP. Respondents from the hospitals had slightly higher PrEP stigma than those from KPLHS.ConclusionsAccording to our findings, at the policy level, the campaign to provide PrEP education to all groups of people should be continued in order to promote a positive view of PrEP and reduce PrEP-related stigma among the general population, which is critical for successful PrEP implementation.
Associations between air pollution and multimorbidity in the UK Biobank: A cross-sectional study
Authors: Ronaldson Amy , Arias de la Torre Jorge , Ashworth Mark , Hansell Anna L. , Hotopf Matthew , Mudway Ian , Stewart Rob , Dregan Alex , Bakolis Ioannis 
Published: December 2022

BackgroundLong-term exposure to air pollution concentrations is known to be adversely associated with a broad range of single non-communicable diseases, but its role in multimorbidity has not been investigated in the UK. We aimed to assess associations between long-term air pollution exposure and multimorbidity status, severity, and patterns using the UK Biobank cohort.MethodsMultimorbidity status was calculated based on 41 physical and mental conditions. We assessed cross-sectional associations between annual modeled particulate matter (PM)2.5, PMcoarse, PM10, and nitrogen dioxide (NO2) concentrations (μg/m3–modeled to residential address) and multimorbidity status at the baseline assessment (2006–2010) in 364,144 people (mean age: 52.2 ± 8.1 years, 52.6% female). Air pollutants were categorized into quartiles to assess dose-response associations. Among those with multimorbidity (≥2 conditions; n = 156,395) we assessed associations between air pollutant exposure levels and multimorbidity severity and multimorbidity patterns, which were identified using exploratory factor analysis. Associations were explored using generalized linear models adjusted for sociodemographic, behavioral, and environmental indicators.ResultsHigher exposures to PM2.5, and NO2 were associated with multimorbidity status in a dose-dependent manner. These associations were strongest when we compared the highest air pollution quartile (quartile 4: Q4) with the lowest quartile (Q1) [PM2.5: adjusted odds ratio (adjOR) = 1.21 (95% CI = 1.18, 1.24); NO2: adjOR = 1.19 (95 % CI = 1.16, 1.23)]. We also observed dose-response associations between air pollutant exposures and multimorbidity severity scores. We identified 11 multimorbidity patterns. Air pollution was associated with several multimorbidity patterns with strongest associations (Q4 vs. Q1) observed for neurological (stroke, epilepsy, alcohol/substance dependency) [PM2.5: adjOR = 1.31 (95% CI = 1.14, 1.51); NO2: adjOR = 1.33 (95% CI = 1.11, 1.60)] and respiratory patterns (COPD, asthma) [PM2.5: adjOR = 1.24 (95% CI = 1.16, 1.33); NO2: adjOR = 1.26 (95% CI = 1.15, 1.38)].ConclusionsThis cross-sectional study provides evidence that exposure to air pollution might be associated with having multimorbid, multi-organ conditions. Longitudinal studies are needed to further explore these associations.
Influenza incidence and air pollution: Findings from a four-year surveillance study of prefecture-level cities in China
Authors: Zhang Yu , Wang Shijun , Feng Zhangxian , Song Yang 
Published: December 2022

BackgroundInfluenza is a serious public health problem, and its prevalence and spread show significant spatiotemporal characteristics. Previous studies have found that air pollutants are linked to an increased risk of influenza. However, the mechanism of influence and the degree of their association have not been determined. This study aimed to determine the influence of the air environment on the spatiotemporal distribution of influenza.MethodsThe kernel density estimation and Getis-Ord Gi* statistic were used to analyze the spatial distribution of the influenza incidence and air pollutants in China. A simple analysis of the correlation between influenza and air pollutants was performed using Spearman's correlation coefficients. A linear regression analysis was performed to examine changes in the influenza incidence in response to air pollutants. The sensitivity of the influenza incidence to changes in air pollutants was evaluated by performing a gray correlation analysis. Lastly, the entropy weight method was used to calculate the weight coefficient of each method and thus the comprehensive sensitivity of influenza incidence to six pollution elements.ResultsThe results of the sensitivity analysis using Spearman's correlation coefficients showed the following ranking of the contributions of the air pollutants to the influenza incidence in descending order: SO2 &gt;NO2 &gt;CO&gt; PM2.5 &gt;O3 &gt;PM10. The sensitivity results obtained from the linear regression analysis revealed the following ranking: CO&gt;NO2 &gt;SO2 &gt;O3 &gt;PM2.5 &gt;PM10. Lastly, the sensitivity results obtained from the gray correlation analysis showed the following ranking: NO2 &gt;CO&gt;PM10 &gt;PM2.5 &gt;SO2 &gt;O3. According to the sensitivity score, the study area can be divided into hypersensitive, medium-sensitive, and low-sensitive areas.ConclusionThe influenza incidence showed a strong spatial correlation and associated sensitivity to changes in concentrations of air pollutants. Hypersensitive areas were mainly located in the southeastern part of northeastern China, the coastal areas of the Yellow River Basin, the Beijing-Tianjin-Hebei region and surrounding areas, and the Yangtze River Delta. The influenza incidence was most sensitive to CO, NO2, and SO2, with the occurrence of influenza being most likely in areas with elevated concentrations of these three pollutants. Therefore, the formulation of targeted influenza prevention and control strategies tailored for hypersensitive, medium-sensitive, low-sensitive, and insensitive areas are urgently needed.
Dietary factors and the risk of lung cancer by epidermal growth factor receptor mutation status and histological subtypes
Authors: Yin Xin , Lai Gillianne Geet Yi , Seow Adeline , Tan Daniel Shao Weng , Lim Darren Wan-Teck , Seow Wei Jie 
Published: December 2022

BackgroundPrevious studies have reported differential associations of certain dietary factors such as soy consumption by epidermal growth factor receptor mutant (EGFR +) subtype of non-small cell lung cancer (NSCLC). However, whether the other dietary factors including meat, fruits, and vegetables have differential risks on different histological and molecular subtypes of lung cancer remains unclear. Therefore, we conducted a case-control study to evaluate these associations.MethodsA total of 3,170 cases and 4,238 controls from three different studies (Genes and Environment in Lung Cancer Study, Lung Cancer Consortium Singapore Study, and Multi-ethnic Cohort Study) were included. Information on demographics, lifestyle, and dietary consumption was obtained using questionnaires. Diet was assessed by using the number of standard servings of each item consumed per week. Multivariable logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (CIs) for the association between meat, vegetables, and fruits consumption with lung cancer risk after adjusting for potential confounders.ResultsWe identified a significant inverse association between higher consumption of fruits and the risk of lung cancer (2nd tertile: OR = 0.54, 95%CI = 0.46–0.65; 3rd tertile: OR = 0.77, 95%CI = 0.65–0.91), compared with the lower (1st tertile) consumption of fruits. Higher vegetable consumption was significantly associated with a lower risk of EGFR + lung cancer (OR = 0.69, 95% CI = 0.54–0.88), however, this association was not significant among EGFR wild-type (−) lung cancer. Conversely, higher consumption of total meat (OR = 2.10, 95%CI = 1.58–2.79) was significantly associated with higher lung cancer risk, as compared with the lower consumption group.ConclusionsDifferential associations between vegetable consumption with EGFR mutation status in NSCLC were found. Further prospective studies are warranted to assess this association and elucidate the biological mechanisms.
Consolidation of the Gaia catalogue with Chinese Space Station Telescope astrometry
Authors: Gai M. , Vecchiato A. , Busonero D. , Riva A. , Cancelliere R. , Lattanzi M. , Qi Z. 
Published: December 2022

The issue of preservation and improvement of the Gaia catalogue throughout the next few decades is addressed. The goal of this study is to evaluate the feasibility of astrometric parameter update, for objects already in the catalogue, by inclusion of new observations from other space missions, in particular CSST. The proposed approach consists in modeling the astrometric fit of sources in the extragalactic region of the Gaia sample with new observations, using the stars in the local field as reference for each target. The concept is verified by simulation, in the framework of the expectations on the Gaia astrometric performance and on the data from the forthcoming CSST Optical Survey. This approach can mitigate the natural degradation of the initial precision on coordinates of Gaia sources with time by improving proper motions by a factor >3, thus improving the positional precision in future epochs. Moreover, the catalogue is densified by the inclusion of objects below the Gaia limiting magnitude, improving on the galactic population census and on extragalactic population. CSST-OS data will reduce the Gaia precision degradation on positions by a factor of 2.7 over 30 years and increase the number of available reference sources over 40% of the sky. Future observations from other missions may further improve on the Gaia catalogue by extending the sky coverage and temporal baseline.
Investigating risk factors behind piglet facial and sow teat lesions through a literature review and a survey on teeth reduction
Authors: Chou Jen-Yun , Marchant Jeremy N. , Nalon Elena , Huynh Thuy T. T. , van de Weerd Heleen A. , Boyle Laura A. , Ison Sarah H. 
Published: December 2022

Introduction:Piglet facial and sow teat lesions are the main reported reasons why pig producers routinely practice teeth resection. This is a painful procedure performed on piglets, where their needle teeth are clipped or ground to resect the pointed tip. The practice raises welfare concerns. In contrast to other procedures, such as tail docking, we know little about the risk factors for these two types of lesions.MethodsWe employed two methods to answer these questions: (1) reviewing the literature to identify potential risk factors, and (2) surveying pig production stakeholders worldwide to identify the occurrence of these lesions and the strategies used in practice that enable pig producers to manage or prevent these lesions while avoiding teeth resection. For the literature review, we used Google Scholar to include peer-reviewed publications and gray literature. We distributed the survey using convenience sampling and documented information on the current situation regarding teeth resection, including the methods, frequencies, and reasons for resecting piglets' teeth, the occurrence of piglet facial and sow teat lesions, and measures used to prevent and control these lesions.ResultsThe literature review identified six major risk factors for both lesions, including the presence or absence of teeth resection, housing system, litter size, piglet management, environmental enrichment, milk production and other piglet management practices. However, most studies focused on the effects of the first two factors with very few studies investigating the other risk factors. There were 75 responses to the survey from 17 countries. The survey showed that half of the respondents practiced teeth resection with many recognizing that facial and teat lesions are the main reasons behind this practice. However, many producers used other interventions rather than teeth resection to prevent these lesions. These interventions focused on improving milk production of the sow, managing large litters, and providing environmental enrichment.DiscussionMore research is needed to validate these interventions and more science-based advice is needed to bridge the gap between research and practice to help more producers further understand the cause of piglet facial and sow teat lesions to transition toward the cessation of routine teeth resection.
An Algorithmic Approach for the MIS Repair of Ventral Midline Hernias Associated With Diastasis of the Rectus Abdominis Muscle
Authors: Mandujano Cosman Camilo , Lima Diego L. , Xia Jason , Sreeramoju Prashanth , Malcher Flavio 
Published: December 2022

Purpose: We present our algorithmic approach for symptomatic ventral hernias with Diastasis of the Rectus Abdominis Muscle (DRAM).Methods: Retrospective analysis of patients with symptomatic ventral hernias and DRAM undergoing hernia repair and plication of DRAM from July 2018–March 2021 was conducted. Based on our algorithm, patients were selected for an Endoscopic Onlay Repair (ENDOR) or a Robotic Extended Totally Extraperitoneal Ventral Repair (R-eTEP).Results: We performed a R-eTEP in fifty-seven patients and an ENDOR in twenty-four patients. In the R-eTEP group, thirty-seven (65%) patients were female, the mean age was 54.8 (±10.6), and the mean BMI was 32 (±4.8). Fifty patients (87.7%) had multiple defects, of which 19 (38%) were recurrent hernias and 31 (62%) were incisional hernias. The mean operative time was 200 (±62.4) minutes, with two cases requiring a hybrid approach. The median length of stay was 1 day (0–12), and the median follow-up was 103 days. Twenty-four patients underwent an ENDOR, 19 females (79.2%), the mean age was 45.7 years (±11.7) and the mean BMI was 28 (±3.6). 13 patients had isolated umbilical or epigastric hernias. The mean operative time was 146.2 min (±51.1). Fibrin sealant and suture was the predominant method for mesh fixation, and most cases were performed in an ambulatory setting. Four patients developed post-operative seromas; one requiring drainage due to infection. The Median follow-up was 48.5 days (10–523), with two reported hernia recurrences.Conclusion: An algorithmic approach for adequate patient selection was shown to be safe for treating ventral hernias with DRAM.
Characteristics of Kidney Recipients of High Kidney Donor Profile Index Kidneys as Identified by Machine Learning Consensus Clustering
Authors: Thongprayoon Charat , Radhakrishnan Yeshwanter , Jadlowiec Caroline C. , Mao Shennen A. , Mao Michael A. , Vaitla Pradeep , Acharya Prakrati C. , Leeaphorn Napat , Kaewput Wisit , Pattharanitima Pattharawin , Tangpanithandee Supawit , Krisanapan Pajaree , Nissaisorakarn Pitchaphon , Cooper Matthew , Cheungpasitporn Wisit 
Published: December 2022

Background: Our study aimed to characterize kidney transplant recipients who received high kidney donor profile index (KDPI) kidneys using unsupervised machine learning approach. Methods: We used the OPTN/UNOS database from 2010 to 2019 to perform consensus cluster analysis based on recipient-, donor-, and transplant-related characteristics in 8935 kidney transplant recipients from deceased donors with KDPI ≥ 85%. We identified each cluster’s key characteristics using the standardized mean difference of >0.3. We compared the posttransplant outcomes among the assigned clusters. Results: Consensus cluster analysis identified 6 clinically distinct clusters of kidney transplant recipients from donors with high KDPI. Cluster 1 was characterized by young, black, hypertensive, non-diabetic patients who were on dialysis for more than 3 years before receiving kidney transplant from black donors; cluster 2 by elderly, white, non-diabetic patients who had preemptive kidney transplant or were on dialysis less than 3 years before receiving kidney transplant from older white donors; cluster 3 by young, non-diabetic, retransplant patients; cluster 4 by young, non-obese, non-diabetic patients who received dual kidney transplant from pediatric, black, non-hypertensive non-ECD deceased donors; cluster 5 by low number of HLA mismatch; cluster 6 by diabetes mellitus. Cluster 4 had the best patient survival, whereas cluster 3 had the worst patient survival. Cluster 2 had the best death-censored graft survival, whereas cluster 4 and cluster 3 had the worst death-censored graft survival at 1 and 5 years, respectively. Cluster 2 and cluster 4 had the best overall graft survival at 1 and 5 years, respectively, whereas cluster 3 had the worst overall graft survival. Conclusions: Unsupervised machine learning approach kidney transplant recipients from donors with high KDPI based on their pattern of clinical characteristics into 6 clinically distinct clusters.
HUBUNGAN MENARCEH DAN DISMINOREA DENGAN SIKLUS MENSTRUASI PADA REMAJA PUTRI
Authors: Fitria Lina , Ofan Hilki 
Published: December 2022

Gizi yang kurang pada remaja putri dapat mempengaruhi pematangan seksual, pertumbuhan, fungsi organ tubuh dan akan menyebabkan terganggunya fungsi reproduksi. Asupan gizi yang tidak adekuat menyebabkan ketidakteraturan menstruasi pada kebanyakan remaja putri serta gizi yang adekuat pada remaja adalah gizi yang bervariasi dan seimbang. Tujuan: untuk mengetahui adanya hubungan status gizi dengan siklus menstruasi pada remaja putri. Metode penelitian: adalah analitic survey dengan menggunakan metode pendekatan croossectional. Populasi dalam penelitian adalah seluruh remaja putri berjumlah 126 orang dengan teknik sampling adalah total samping. Instrument yang digunakan dalam penelitian adalah kuesioner. Penelitian ini dilaksanakan di Madrasah Aliyah (MA) DDI Kanang Kabupaten Polewali Mandar Tahun 2019. Hasil: penelitian mengungkapkan sebanyak 77 responden (61,1%) dan yang memilki siklus menstruasi normal sebanyak 101 responden (80,2%). Hasil penelitian Menggunakan uji Chi Square didapatkan nilai ρ 0,00 < 0,05. Rekomendasi: bahwa terdapat hubungan antara status gizi dengan siklus menstruasi pada remaaja putri di MA DDI Kanang Polewali Mandar. Oleh karena itu diharapkan tenaga kesehatan memperbanyak penyuluhan tentang kesehatan khususnya bagi remaja putri tentang pentingnya nutrisi yang seimbang terhadap keseimbangan metabolisme tubuh yang berdampak pada siklus menstruasi pada setiap bulannya.
ANALISIS PENGELOLAAN DAN KONTRIBUSI RETRIBUSI PASAR TAPALANG TERHADAP PENDAPATAN ASLI DAERAH DI PASAR TAPALANG KABUPATEN MAMUJU
Authors: Jamaluddin Jamaluddin , Adnan Mohammad Arfandi , Daud Yusuf 
Published: December 2022

Penelitian ini menggunakan metode kualitatif dengan lokasi penelitian di Pasar Tapalang Kecamatan Mamuju Kabupaten Mamuju. Subyek penelitian ini adalah Instansi yang terkait, Kepala Pasar bersama dengan kollektor, masyarakat pasar/konsumen, dan pedagang pengguna pasar. Hasil penelitian menunjukan bahwa Berdasarkan data yang diperoleh dari daerah bahwa potensi retribusi Pasar Tapalang dapat dilihat dari banyaknya Toko, kios, lods, pelataran dan gardu yang belum dimanfaatkan oleh para pedagang, atau penjual sehingga menjadi hambatan yang dihadapi dalam mencapai target dalam penagihan Retribusi Pasar Tapalang Terhadap Pendapatan Asli Daerah Di Pasar Tapalang Berdirinya Alfamidi/alfa mart tidak jauh dari lokasi pasar Tapalang, beberapa toko yang tidak berfungsi, banyaknya kios yang tidak digunakan, banyaknya los yang tidak terpakai, seta adanya pedagang musiman yang tidak mampu diprediksi.
FAKTOR RISIKO KEJADIAN HIPERTENSI DI WILAYAH KERJA PUSKESMAS BALLA KECAMATAN BALLA KABUPATEN MAMASA SULAWESI BARAT
Authors: Abidin Urwatil Wusqa , Liliandriani Andi , Suryani Suryani 
Published: December 2022

Hipertensi merupakan penyakit degeneratif yang menjadi salah satu penyebab kematian di dunia dan salah satu penyakit yang serius di Indonesia. Prevalensi peningkatan hipertensi dapat disebabkan oleh gaya hidup, riwayat keluarga dan faktor lainya. Penelitian ini bertujuan untuk menganalisis faktor resiko terhadap kejadian hipertensi di wilayah kerja Puskesmas Balla Kecamatan Balla Kabupaten Mamasa. Jenis penelitian yang digunakan survey analitik observasional dengan desain case control. Adapun sampel pada penelitian ini menggunakan metode purposive sampling dengan menggunakan rumus Lemeshow 1998 yang diolah dengan menggunakan samplesize 2.0 dari WHO, sehingga menghasilkan jumlah sampel pada kelompok kasus 55 responden dan kelompok kontrol 55 responden. Pengumpulan data dilakukan dengan menggunakan SPSS. Data kemudian di analisis dengan uji Cji-Square dengan tingkat signifikan α = 0,05. Hasil analisis bivariat menunjukan faktor resiko merokok tidak ada hubungan d engan kejadian hipertensi di wilayah kerja Puskesmas Balla dengan nilai ( p=0,00) ,faktor resiko riwayat keluarga dengan nilai (OR = 0,58; p = 0,00), yang artinya ada hubungan terhadap kejadian hipertensi di Puskesmas Balla dan faktor resiko obesitas di dapatkan tidak ada hubungan dengan kejadian hipertensi dengan nilai (p =1,00). Diharapkan pada tenaga kerja di wilayah kerja Puskesmas Balla terus meningkatankan pelayanan kesehatan dan penberiaan informasi mengenai faktor-faktor resiko yang dapat menyebabkan penyakit hipertensi bagi masyarakat.