bluuebunny/crossref_metadata_2025_split huggingface dataset:
Feasibility of a comprehensive medication review to improve medication use for patients with cancer and comorbid conditions
Authors: Mackler Emily R. , Azar Michelle K. , Johengen Emily , Farris Karen B. , Thompson Amy N. 
Published: October 2022

Abstract
Purpose
A focus on oral medications for patients receiving care from both oncologists and primary care providers elicits an opportunity for improvement in patient outcomes. The purpose of this pilot study was to explore the feasibility and appropriateness of a comprehensive medication review (CMR) by a primary care pharmacist in a population of patients with cancer and chronic conditions.

Methods
Adult patients who received both cancer and primary care at Michigan Medicine, received active systemic cancer treatment, and had a comorbid condition of diabetes, hypertension, chronic heart failure, depression, and/or anxiety were eligible to receive a CMR by the primary care clinical pharmacist. Data collected included number eligible for the CMR (feasibility), patient demographics, medication-related problems (MRPs) and medication interventions (appropriate), number of patients requiring follow-up with the clinical pharmacist or physician, and pre/post-intervention changes in A1c and BP, as applicable.

Results
Of the 96 patients that met inclusion criteria, 55 patients (57%) received a CMR. Pharmacists provided 66 instances of patient education and identified 22 medication-related problems (MRPs) in 15 (27%) of patients. After CMRs were completed, 22 patients (40%) were referred to primary care pharmacists or physician providers for ongoing care.

Conclusion
A CMR was feasible and appropriate for patients with chronic conditions receiving treatment for cancer.
War in Ukraine: a neurosurgical perspective
Authors: Dubinski Daniel , Kolesnyk Volodymyr 
Published: October 2022

Abstract
Background
The ongoing war in Ukraine leads to the destruction of critical infrastructure and the displacement of millions of civilians while the necessity for neurosurgical care has increased tremendously. The consequences of this armed conflict on the practice of neurosurgery are uncertain to date.

Methods
A cloud-based questionnaire including 10 single- and multiple-choice questions was sent through the email distribution list of the Ukrainian Neurosurgical Society and the Association of Neurosurgeons of Ukraine.

Results
Between June 2022 and July 2022, a link to the online survey was distributed to a total of 134 (100%) departments of neurosurgery across Ukraine. After 21 days of being available, a total of 96 questionnaires (72%) returned.

Conclusions
The survey highlights the field of activity as well as the severe impact on professional and personal life of Ukrainian neurosurgeons during the ongoing war.
Comparative study of the modified VISTA technique (m-VISTA) versus the coronally advanced flap (CAF) in the treatment of multiple Miller class III/RT2 recessions: a randomized clinical trial
Authors: Fernández-Jiménez Aitziber , Estefanía-Fresco Ruth , García-De-La-Fuente Ana María , Marichalar-Mendia Xabier , Aguirre-Urizar José Manuel , Aguirre-Zorzano Luis Antonio 
Published: October 2022

Abstract

Objectives
To compare the percentage of mean root coverage (MRC%) obtained in the treatment of multiple Miller class III/RT2 gingival recessions using the modified VISTA (m-VISTA) technique versus the coronally advanced flap (CAF) technique, using a connective tissue graft (CTG) in both cases.

Materials and methods
Twenty-four patients were randomly treated with m-VISTA (test group (TG) = 12) or CAF (control group (CG) = 12). A calibrated, experienced, and blinded examiner collected data related to multiple periodontal clinical variables, especially the recession (REC) in order to calculate the MRC% at 6 and 12 months, which was the primary outcome of the study. Also, the radiological bone level, the characteristics of the CTG, and postsurgical incidences were assessed. Finally, a descriptive and an analytical statistical analysis of the variables and their associations was performed.

Results
The recessions (n = 84) were located mainly in the mandible (n = 65) and in posterior sectors (premolars: n = 35; molars: n = 8). At 6 months, the MRC% was 61% (2 mm) for both study groups, and at 12 months, it increased to 73.26% (2.11 mm) in the TG and decreased to 56.49% (1.78 mm) in the CG.

Conclusion
When approaching multiple Miller class III/RT2 recessions, there were no statistically significant differences in the MRC% at 6 and 12 months between the group treated with the m-VISTA technique and the group treated with the CAF.

Clinical relevance
The characteristics of the m-VISTA technique, such as the closed approach, the mobilization of the papilla, and the coronal stabilization of the CTG, could facilitate the maturation of the tissues in the treatment of Miller class III/RT2 recessions. This would favor better root coverage.

Trial registration
NCT03258996.
Auswirkungen der Fit-for-55-Instrumente auf die Preise in der Luftfahrt
Authors: Ehlers Thorsten , Kölker Katrin , Lütjens Klaus 
Published: October 2022

ZusammenfassungDie Europäische Union strebt mit den Maßnahmen des Fit-for-55-Pakets eine Verringerung der CO2-Emissionen bis 2030 um 55% an, verglichen mit dem Stand von 1990. Diese Reduktion soll durch verschiedene Maßnahmen erreicht werden, die auch die kommerzielle Luftfahrt betreffen. Dies sind unter anderem eine Verschärfung des Emissionshandels, bei der insbesondere die frei zugeteilten Zertifikate zügig abgebaut werden sollen, eine verpflichtende Beimischungsquote für nachhaltige Flugtreibstoffe an europäischen Flughäfen sowie eine europaweite Mindesthöhe für Steuern auf Treibstoffe. Dadurch verteuern sich die Flüge in verschiedenen Gebieten unterschiedlich.
Regionale Wasserstoffpotenziale
Authors: Bräuninger Michael , Stiller Silvia , Teuber Mark-Oliver 
Published: October 2022

AbstractThe paper analyses the potential of the hydrogen economy in German districts and cities. The paper focuses particularly on regions suffering from strong ongoing structural change. The assessment is based on quantitative indicators for the supply structures (renewable energy, pipeline network), the demand side (industry, transport and heat), and on regional knowledge (research institutions and projects). The results show four regional clusters suffering from structural change that could potentially establish a hydrogen economy. These regions will benefit from investments in hydrogen structures and the associated strengthening of regional value chains.
Differential effects and success stories of distance education in Covid-19 lockdowns on the development of reading comprehension in primary schools
Authors: Segers Eliane , In ’t Zandt M. , Stoep J. , Daniels L. , Roelofs J. , Gubbels J. 
Published: October 2022

AbstractIn the current study, the development in reading comprehension performance of students in lower-SES versus higher-SES schools during and after school closures due to Covid-19 lockdowns was examined, and compared to a normed reference group. Furthermore, we explored protective factors against negative effects at the time of school closures, by pinpointing successful practices in a sub sample of resilient lower-SES schools. The total sample consisted of 2202 students followed from grade 2–4. Overall, we found that students in lower-SES schools made less progress over time than students in higher-SES schools. On average, students made less progress during the lockdowns, but here, the interaction with SES was not significant. Students' reading comprehension levels partially recovered after the lockdowns. Questionnaire-data revealed that schools were better prepared during the second lockdown, with teachers making more use of digital means, and providing more online reading instruction. In addition, collaboration with the parents seemed to have improved. The in depth interviews with resilient lower-SES schools revealed that the introduction of online education and investing in educational partnerships with parents may have helped to minimize the negative impact of lockdowns. We conclude that lockdowns have a negative effect on the development of reading education, but that students are resilient. Digital means and partnership with parents may be seen as protective factors to attenuate the negative effects of emergency remote teaching.
Mates and the hierarchy
Authors: Rattan Gurpreet , Durand Marion 
Published: October 2022

AbstractMates’s Puzzle has flown below many philosophers’ radar, despite its relations to both Frege’s Puzzle and the Paradox of Analysis. We explain the relations amongst these puzzles on the way to arguing that Mates’s Puzzle suggests a generalization of Frege’s Puzzle, and of the sense-reference distinction itself, in the form of hierarchy of senses. We explain how Mates’s Puzzle and the hierarchy, to different degrees, illuminate each other, and how their connection is missed in the literature. However, we argue that the potential of Mates’s Puzzle to illuminate the hierarchy is yet to be fully actualised. We suggest that in order to do better, we need to formulate Mates’s Puzzle as a puzzle in the philosophy of thought and not as puzzle in the philosophy of language. What is needed, to which the present paper is a precursor, is an account of the cognitive significance of higher-order senses.
Seroprevalence of camel brucellosis in Qatar
Authors: Alhussain Hashim , Zughaier Susu M. , Gawish Ahmed , Mahmoud Mahmoud H. , Yassine Hadi M. , Al Thani Asmaa , Obied Tahra El- , Al-Zeyara Abdulaziz M. , Eltai Nahla O. 
Published: October 2022

Abstract
Brucellosis is a significant zoonotic disease and one of the most common neglected diseases worldwide. It can infect a wide range of domestic and wild animal species. Infected animals are usually culled, causing substantial economic losses to animal owners and the country’s economy in general. The disease is endemic among cattle, sheep, and goats in many countries around the Middle East and prevalent in most Gulf Cooperation Council countries, comprising a significant public health risk in the region. This study investigated the seroprevalence of brucellosis among camels in Qatar. Two hundred and forty-eight samples were collected from dromedary camels from 28 farms across the entire country. Each sample was tested for Brucella antibodies with both Rose Bengal and competitive enzyme-linked immunosorbent assay. Only samples that tested positive by both tests were considered seropositive for brucellosis. The overall prevalence was (20.6%, 95% CI, 15.7–26.1). The association between sex and seropositivity was slightly significant (Χ2 = 4.32, P = 0.04), with higher seroprevalence in females. Camels below breeding age (i.e., < 4 years old) showed decreased seropositivity (3.4%, 95% CI, 0.1–17.8), compared to (22.8%, 95% CI, 17.4–29.0) seropositivity in camels ≥ 4 years of age, with a significant association between age groups and seropositivity (P = 0.02). Our results indicate that the seroprevalence of brucellosis in Qatar’s camels is alarming, mandating more efforts to control the disease. The findings of this study will aid in selecting better effective measures to control camel brucellosis in Qatar. Further studies need to be conducted on Brucella infection among camels to determine the predisposing risk factors and the steps that should be followed to control brucellosis.
Concentration of mercury in human hair and associated factors in residents of the Gulf of Trieste (North-Eastern Italy)
Authors: Cegolon Luca , Petranich Elisa , Pavoni Elena , Floreani Federico , Barago Nicolò , Papassissa Elisa , Larese Filon Francesca , Covelli Stefano 
Published: October 2022

AbstractThe Gulf of Trieste (Northern Adriatic Sea, Italy) is the coastal area of the Mediterranean Sea most highly contaminated by mercury (Hg) due to fluvial inputs from the Isonzo/Soča River system, draining over 500 years’ worth of cinnabar extraction activity from the Idrija mining district (Western Slovenia). The aim of this research is to investigate the concentration of Hg in hair samples taken from the general population of the Friuli Venezia Giulia (FVG) Region coastal area, as a marker of chronic exposure to Hg. Three hundred and one individuals — 119 males and 182 females — were recruited by convenience sampling in Trieste in September 2021. An amount of approximately 100 mg of hair was collected from the occipital scalp of each participant to measure the respective Hg concentrations (expressed as mg/kg). Moreover, participants completed a self-report questionnaire collecting extensive socio-demographic and life-style information. A multiple linear regression analysis was employed to investigate factors associated with increased levels of Hg concentration in hair. A mean Hg concentration in hair of 1.63 mg/kg was found, slightly above the 1.0 mg/kg threshold recommended by the WHO for pregnant women and children, although still well below the no observed adverse effects level (NOAEL) of 10 mg/kg. Among respondents, 55.6% showed a Hg concentration in hair > 1 mg/kg, 22.9% > 2 mg/kg, and 2 participants exhibited Hg levels > 10 mg/kg. The adjusted mean hair Hg level increased in those subjects who reported a preference for shellfish/crayfish/mollusks (RC = 0.35; 95%CI: 0.16; 0.55), whereas it decreased in those who reported a preference for frozen fish (RC = -0.23; 95%CI: − 0.39; − 0.06). Though a risk alert for Hg exposure for coastal residents from FVG is deemed unnecessary at this time, it is recommended that pregnant women limit their ingestion of locally caught fish to < 4 servings/month.
Interactive visual exploration of surgical process data
Authors: Mayer Benedikt , Meuschke Monique , Chen Jimmy , Müller-Stich Beat P. , Wagner Martin , Preim Bernhard , Engelhardt Sandy 
Published: October 2022

Abstract
Purpose
Integrated operating rooms provide rich sources of temporal information about surgical procedures, which has led to the emergence of surgical data science. However, little emphasis has been put on interactive visualization of such temporal datasets to gain further insights. Our goal is to put heterogeneous data sequences in relation to better understand the workflows of individual procedures as well as selected subsets, e.g., with respect to different surgical phase distributions and surgical instrument usage patterns.

Methods
We developed a reusable web-based application design to analyze data derived from surgical procedure recordings. It consists of aggregated, synchronized visualizations for the original temporal data as well as for derived information, and includes tailored interaction techniques for selection and filtering. To enable reproducibility, we evaluated it across four types of surgeries from two openly available datasets (HeiCo and Cholec80). User evaluation has been conducted with twelve students and practitioners with surgical and technical background.

Results
The evaluation showed that the application has the complexity of an expert tool (System Usability Score of 57.73) but allowed the participants to solve various analysis tasks correctly (78.8% on average) and to come up with novel hypotheses regarding the data.

Conclusion
The novel application supports postoperative expert-driven analysis, improving the understanding of surgical workflows and the underlying datasets. It facilitates analysis across multiple synchronized views representing information from different data sources and, thereby, advances the field of surgical data science.
Kind – und dann? Wandel partnerschaftlicher Erwerbsverläufe drei Jahre nach dem Übergang in die Elternschaft
Authors: Kelle Nadiya , Romeu Gordo Laura , Simonson Julia 
Published: October 2022

ZusammenfassungDer Übergang in die Elternschaft markiert für viele Elternpaare den Übergang in geschlechterspezifische Erwerbsarrangements, oft unabhängig von der gelebten vorgeburtlichen Arbeitsteilung. Dabei können die Entscheidungen über die Erwerbsarrangements nach der Geburt des ersten Kindes richtungsgebend für die zukünftigen Erwerbsverläufe und Alterssicherung sein. Vor diesem Hintergrund fokussiert der Beitrag auf zwei Fragen: erstens, ob sich gerade für jüngere Elternpaare der in den 1980er-Jahren Geborenen eine Konvergenz in den Erwerbsverläufen nach dem Übergang in die Elternschaft im Vergleich zu den in den 1970er-Jahren geborenen Elternpaaren zeigt und zweitens, ob die Arbeitsteilung vor dem Übergang in die Elternschaft eine zunehmende Rolle für die Erwerbskonstellationen danach spielt. Unter Verwendung der Daten des Sozio-oekonomischen Panels (SOEP) werden anhand sequenz-, cluster- und regressionsanalytischer Verfahren Erwerbsverläufe von 900 Paaren über 36 Monate nach dem Übergang in die Elternschaft analysiert. Für die Kohorte der in den 1980er-Jahren Geborenen setzt sich die Bedeutungsabnahme traditioneller Erwerbsarrangements fort. Zudem gibt es immer mehr Elternpaare, in denen beide Elternteile relativ schnell nach der Geburt eines Kindes in die Erwerbstätigkeit zurückkehren. Kaum zu beobachten ist, dass Väter ihre Erwerbstätigkeit zunehmend zugunsten einer stärkeren Einbindung in Haushalts- oder Familientätigkeiten einschränken. Hingegen scheinen die Konvergenzen in den Erwerbsverläufen zwischen Müttern und Vätern vielmehr ein Resultat zunehmender Erwerbsdiskontinuitäten zu sein. Darüber hinaus hat die vorgeburtliche Arbeitsteilung auch für die jüngeren Elternpaare einen eher geringen Einfluss auf ihre nachgeburtlichen Erwerbskonstellationen. Die Ergebnisse legen nahe, dass der Abbau von geschlechterspezifischen Ungleichheiten am Arbeitsmarkt verstärkt voranzutreiben ist, damit weitere Anreize für die gleichmäßigere Erwerbsaufteilung im Paarkontext entstehen können.
Surgical Principles in the Management of Lung Neuroendocrine Tumors: Open Questions and Controversial Technical Issues
Authors: Brascia Debora , Marulli Giuseppe 
Published: October 2022

Opinion statementPrimary neuroendocrine tumors (NETs) of the lung represent a heterogeneous group of malignancies arising from the endocrine cells, involving different entities, from well differentiated to highly undifferentiated neoplasms. Because of the predominance of poorly differentiated tumors, advanced disease is observed at diagnosis in more than one third of patients making chemo- or chemoradiotherapy the only possible treatment. Complete surgical resection, as defined as anatomical resection plus systematic lymphadenectomy, becomes a reliable curative option only for that little percentage of patients presenting with stage I (N0) high-grade NETs. On the other hand, complete surgical resection is considered the mainstay treatment for localized low- and intermediate-grade NETs. Therefore, in the era of the mini-invasive surgery, their indolent behavior has suggested that parenchyma-sparing resections could be as adequate as the anatomical ones in terms of oncological outcomes, leading to discuss about the correct extent of resection and about the role of lymphadenectomy when dealing with highly differentiated NETs.
Awareness-independent gradual spread of object-based attention
Authors: Huang Ling , Chen Yu , Shen Shiqi , Ye Haoxian , Ou Shipei , Zhang Xilin 
Published: October 2022

AbstractAlthough attention can be directed at certain objects, how object-based attention spreads within an object and whether this spread interacts with awareness remain unclear. Using a modified spatial cuing paradigm with backward masking, we addressed these issues with either visible or invisible displays presenting the real (Experiment 1) and illusory (Experiment 2) U-shaped objects (UOs), whose ends and middles, the possible locations of the cue and target, have iso-eccentric distances from the fixation. These equidistant ends and middles of UOs offered us a unique opportunity to examine whether attention gradually spreads within a given object, i.e., within an UO, attention spreads from its cued-end to uncued-end via the uncued-middle. Despite the visibility (visible or invisible) of UOs, both experiments supported this gradual spread manner by showing a faster response of human participants (male and female) to the target in the uncued-middle than that in the uncued-end. Our results thus indicate a gradual spread of object-based attention and further reveal that this gradual spread is independent of both the “visual objectness” (whether the object is defined as the real or illusory boundaries) and conscious access to objects.
Earth Science, Art and Coastal Engineering at the Seaside: Envisioning an Open Exploratorium or Geo-Promenade at Weston-super-Mare, Somerset, United Kingdom
Authors: Whalley W. Brian 
Published: October 2022

AbstractThe paper outlines how an outdoor ‘exploratorium’ can be curated to place field observations, together with some knowledge of the local environment, in a manner that relates to geology, geomorphology and artistic aesthetics. The exploratorium can also be used to help explain what is seen, touched or felt as part of ‘sensory geology’. The locations used are on an accessible walk, a geo-promenade, along the sea front of a coastal town, Weston-super-Mare, England. Sites, such as a sea wall and recent engineering structures, are linked to flood prevention measures and sculpture and stone promenade furniture relate to various aspects of geoheritage. Notions of consilience and decision-making in the behavioural environment are introduced, together with ways in which perceptions of the landscape can be shared with visually impaired visitors. Notes are provided to illustrate the additional information (metadata) that might be supplied in constructing a geo-promenade. The use of mobile technologies for recording observations, providing locations (using decimal Latitude Longitude designations) and general information is also discussed with respect to accessible visits. Attention is also given to cognition and educational models of experiential discussion and knowledge sharing that can be used in exploratoria and geoheritage in general.
Special solutions to the space fractional diffusion problem
Authors: Namba Tokinaga , Rybka Piotr , Sato Shoichi 
Published: October 2022

AbstractWe derive a fundamental solution $${{\mathscr {E}}}$$
E
to a space-fractional diffusion problem on the half-line. The equation involves the Caputo derivative. We establish properties of $${{\mathscr {E}}}$$
E
as well as formulas for solutions to the Dirichlet and fixed slope problems in terms of convolution of $${{\mathscr {E}}}$$
E
with data. We also study integrability of derivatives of solutions given in this way. We present conditions, which are sufficient for uniqueness of solutions. Finally, we show the infinite speed of signal propagation.