bluuebunny/crossref_metadata_2025_split huggingface dataset:
Triaging your human capital: an integrative perspective on strategic human capital asset allocation
Authors: Bonner Robert L. , Neely Andrea R. , Stone Christopher B. , Lengnick-Hall Cynthia A. , Lengnick-Hall Mark L. 
Published: May 2022

Purpose
The purpose of this paper is to provide an overarching framework to guide the understanding of the allocation and deployment of strategic human capital assets within an organization. Using the concept of medical triage with business units analogous to “patients” and their performance to “symptoms or injuries,” the framework suggests a “steal from the poor” perspective that is counter to conventional organizational decline literature.

Design/methodology/approach
This is a conceptual paper proposing that there are five different categories of business unit need for human capital assets: expectant, deceased, immediate, delayed or minimal; all based on the type of environment and holistic performance of the business unit. Based on a business unit’s specific situation, the authors suggest a process model guiding how to conduct a triage analysis to optimize the allocation of strategic human capital assets within an organization.

Findings
The authors argue that current trends in assessing strategic human capital assets which make comparisons across organizations are necessary but insufficient (e.g. comparing a store to other stores in its district or region). Each business unit has its own unique internal capabilities and external constraints that also must be accurately assessed to make an informed organizational-level decision about where and how to deploy strategic human capital assets.

Originality/value
Borrowing from medical science, this paper demonstrates a new conceptual framework with propositions for researchers and guidance for practitioners.
Artificial intelligence and the changing landscape of accounting: a viewpoint
Authors: Kommunuri John 
Published: May 2022

Purpose
The study aims to explore the changing landscape of accounting and the role of emerging technologies in the accounting environment. The author presents viewpoints on the influence of artificial intelligence (AI), machine learning (ML) and other subsets in accounting, emphasising the increasing need for and significance of these applications. The viewpoints could provide researchers and practitioners with a meaningful overview of knowledge and research agenda.

Findings
The role of emerging technologies in accounting and various opportunities and challenges in implementation are discussed. In addition, possible future research directions are identified.

Research limitations/implications
The paper does not contain empirical findings.

Originality/value
This paper expresses the author’s viewpoints regarding the impact of AI and ML on the changing accounting environment.
‘He called me out of the blue’: An ethnographic exploration of contrasting temporalities in a social prescribing intervention
Authors: Gibson Kate , Moffatt Suzanne , Pollard Tessa M. 
Published: May 2022

AbstractSocial prescribing, a way of connecting patients to local services, is central to the NHS Personalised Care agenda. This paper employs ethnographic data, generated with 19 participants between November 2018 and July 2020, to explore the socio‐temporal relations shaping their experiences of a local social prescribing intervention. Our focus is on the ways in which the intervention synchronised with the multitude of shifting, complex and often contradictory ‘timespaces’ of our participants. Our focus on the temporal rhythms of everyday practice allows us to trace a tension between the linearity and long horizon of the intervention and the oft contrasting timeframes of participants, sometimes leading to a mismatch that limited the intervention's impact. Further, we observed an interventional ‘drift’ from continuity towards unsupported signposting and ‘out‐of‐the‐blue’ contacts which favour the temporality of the intervention. We demonstrate a need for intervention planning to be flexible to multiple, often conflicting, temporalities. We argue that health interventions must account for the temporal relations lived by the people they seek to support.
MiR‐379‐5p inhibits the proliferation, migration, and invasion of breast cancer by targeting KIF4A
Authors: Yang Ke , Li Danyang , Jia Weihui , Song Yanmei , Sun Ningxin , Wang Jiemin , Li Hongli , Yin Chonggao 
Published: May 2022

AbstractBackgroundMany studies have shown that microRNAs (miRNAs) play an essential role in gene regulation and tumor development. This study aimed to explore the expression of miR‐379‐5p and its mechanisms of affecting proliferation, migration, and invasion in breast cancer (BC).MethodsMiRNAs and mRNAs expression data of BC and normal breast tissue samples were downloaded from the TCGA and GEO databases. qRT‐PCR was used to detect the expression of miR‐379‐5p in human normal breast epithelial cell lines and human BC cell lines. The proliferation ability of transfected cells was detected by colony formation and EdU assays. The mobility and invasion ability of transfected cells was measured by wound healing and transwell assays. The relative protein expression of transfected cells was detected by western blot. Dual luciferase reporter assay was performed to identify the targeted binding of miR‐379‐5p and KIF4A.ResultsMiR‐379‐5p was lowly expressed in BC tissue samples and BC cell lines. The target genes of miR‐379‐5p were involved in many cancer‐related signaling pathways. PPI analysis and the cytoHubba algorithm of Cytoscape identified 10 genes as the hub genes. Survival analysis showed that only KIF4A expression in 10 hub genes was significantly associated with the prognosis of BC patients and was significantly upregulated in BC. Overexpression of miR‐379‐5p inhibited proliferation, migration, and invasion in the BC cell line MDA‐MB‐231, which could be reversed by KIF4A.ConclusionsMiR‐379‐5p inhibits proliferation, migration, and invasion of BC by targeting KIF4A.
Squirrel and tree‐shrew responses along an urbanisation gradient in a tropical mega‐city – reduced biodiversity, increased hybridisation of Callosciurus squirrels, and effects of habitat quality
Authors: Thaweepworadej P. , Evans K. L. 
Published: May 2022

AbstractUrbanisation is rapidly transforming terrestrial environments, especially in the tropics. Many squirrel species tolerate urbanisation, but studies are biased towards temperate regions. We quantify the distribution and abundance of squirrels and (ecologically similar) tree‐shrews along an urbanisation gradient in a rapidly urbanising tropical mega‐city (Bangkok, Thailand) located within the Indo‐Burma biodiversity hotspot. We used repeated point counts in 150 1 km cells, selected using random stratification across the urbanisation gradient. We quantified species responses to (i) urbanisation intensity (measured using impervious surface cover), (ii) environmental conditions (woodland quantity and quality, human disturbance and predation pressure from free‐ranging cats and dogs) and (iii) urbanisation impacts on hybridisation between congeneric Callosciurus squirrels. Three of the six species from the regional species pool were extremely rare or absent within our study region (Tamiops macclellandi, Callosciurus caniceps and Menetes berdmorei). Of the three more widespread species (Tupaia belangeri, Callosciurus finlaysonii and Callosciurus erythraeus) only C. finlaysonii had a higher abundance in more urban locations. The increasing intensity of urbanisation has thus markedly reduced squirrel diversity and abundance, contrasting with the perception from temperate regions that squirrels typically tolerate urbanisation. Urbanisation is thus likely to have reduced important ecological functions provided by squirrels, such as seed dispersal. Models of species responses to environmental conditions suggest that improving habitat quality by increasing tree cover and diversity at local and landscape scales and reducing human disturbance and numbers of feral dogs would partially mitigating adverse impacts of urbanisation on tropical squirrels and tree‐shrews. Urban infrastructure (bridge construction across the Chao‐Praya River) appears to have increased the permeability of a geographic barrier that previously separated C. finlaysonii and C. erythraeus distributions, increasing hybridisation rates. Our study enhances understanding of the ecological impacts of urbanisation in biodiverse tropical regions and the action required to mitigate these impacts.
Factors associated with labor after cesarean in a prospective cohort
Authors: Attanasio Laura B. , Paterno Mary T. , Kjerulff Kristen H. 
Published: May 2022

AbstractBackgroundThe goals of this study were (a) to determine how experiences in the first perinatal period shape birth mode preference among individuals with a first birth by cesarean; and (b) to examine the relationship between birth mode preference and other factors and subsequent labor after cesarean (LAC).MethodsData are from the First Baby Study, a prospective cohort of 3006 primiparous individuals. The analytic sample includes individuals with a first cesarean birth and a second birth during the 5‐year follow‐up period (n = 394). We used multivariable logistic regression to examine the relationship between experiences in the first perinatal period and subsequent preference for vaginal birth, and between preference for vaginal birth and LAC in the second birth.ResultsAbout a third of the sample preferred vaginal birth in a future birth, and 20% had LAC. Factors associated with higher odds of future vaginal birth preference were favorable prenatal attitude toward vaginal birth, lower perceived maternal‐infant bonding at 1 month after the first birth, post‐traumatic stress symptoms after the first birth, and desiring more than 1 additional child after the first birth. Odds of LAC were nearly 8 times higher among those who preferred vaginal birth (AOR = 7.69, P < .001). Fatigue after the first birth, post‐traumatic stress symptoms after the first birth, and having higher predicted chances of vaginal birth after cesarean were also associated with higher odds of LAC.ConclusionsOur findings suggest that the formation of preferences around vaginal birth may present a modifiable target for future counseling and shared decision‐making interventions.
Coexistence of pachyonychia congenita and hidradenitis suppurativa: more than a coincidence
Authors: Pavlovsky Mor , Peled Alon , Sarig Ofer , Astman Nadav , Malki Liron , Meijers Odile , Assaf Sari , Schwartz Janice , Malovitski Kiril , Hansen David , Sprecher Eli , Samuelov Liat 
Published: May 2022

AbstractBackgroundThe coexistence of pachyonychia congenita (PC) and hidradenitis suppurativa (HS) has been described in case reports. However, the pathomechanism underlying this association and its true prevalence are unknown.ObjectivesTo determine the genetic defect underlying the coexistence of PC and HS in a large kindred, to delineate a pathophysiological signalling defect jointly leading to both phenotypes, and to estimate the prevalence of HS in PC.MethodsWe used direct sequencing and a NOTCH luciferase reporter assay to characterize the pathophysiological basis of the familial coexistence of HS and PC. A questionnaire was distributed to patients with PC registered with the International Pachyonychia Congenita Research Registry (IPCRR) to assess the prevalence of HS among patients with PC.ResultsDirect sequencing of DNA samples obtained from family members displaying both PC and HS demonstrated a missense variant (c.275A&gt;G) in KRT17, encoding keratin 17. Abnormal NOTCH signalling has been suggested to contribute to HS pathogenesis. Accordingly, the KRT17 c.275A&gt;G variant resulted in a significant decrease in NOTCH activity. To ascertain the clinical importance of the association of HS with PC, we distributed a questionnaire to all patients with PC registered with the IPCRR. Seventy-two of 278 responders reported HS-associated clinical features (25·9%). Disease-causing mutations in KRT17 were most prevalent among patients with a dual phenotype of PC and HS (43%).ConclusionsThe coexistence of HS and KRT17-associated PC is more common than previously thought. Impaired NOTCH signalling as a result of KRT17 mutations may predispose patients with PC to HS.What is already known about this topic? The coexistence of pachyonychia congenita (PC) and hidradenitis suppurativa (HS) has been described in case reports. However, the pathomechanism underlying this association and its true prevalence are unknown.What does this study add? A dual phenotype consisting of PC and HS was found to be associated with a pathogenic variant in KRT17. This variant was found to affect NOTCH signalling, which has been previously implicated in HS pathogenesis. HS was found to be associated with PC in a large cohort of patients with PC, especially in patients carrying KRT17 variants, suggesting that KRT17 variants causing PC may also predispose to HS.What is the translational message? These findings suggest that patients with PC have a higher prevalence of HS than previously thought, and hence physicians should have a higher level of suspicion of HS diagnosis in patients with PC.
TRBC1 expression assessed by flow cytometry as a novel marker of clonality in cutaneous αβ T-cell lymphomas with peripheral blood involvement
Authors: Martin-Moro Fernando , Martin-Rubio Isaac , Garcia-Vela Jose A. 
Published: May 2022

Abstract
The TRBC1 evaluation is a useful, simple, and fast flow cytometry tool for the assessment of αβ T-cell clonality in the blood of patients suspicious of mycosis fungoides and Sézary syndrome.
Surviving the COVID‐19 pandemic: The antecedents of success among European SMEs
Authors: Chit Myint Moe , Croucher Richard , Rizov Marian 
Published: May 2022

AbstractWe research the antecedents of relative success among small and medium enterprises (SMEs) in avoiding temporary or permanent closure during the COVID‐19 pandemic. We investigate the roles of firm‐specific resources and state support policies in influencing SME fortunes, in a sizeable group of European countries covered in the World Bank Enterprise Survey. Using resource dependency, Varieties of Capitalism and Systems theories, we find that innovative capacities, institutional connectedness, governance, and management experience were major antecedents of success across all SMEs. Significant differences in outcomes were found between SMEs operating in old and new EU member states, and non‐EU countries.
Clinicopathological features, MCPyV status and outcomes of Merkel cell carcinoma in solid‐organ transplant recipients: a retrospective, multicentre cohort study
Authors: Ferrándiz‐Pulido C. , Gómez‐Tomás A. , Llombart B. , Mendoza D. , Marcoval J. , Piaserico S. , Baykal C. , Bouwes‐Bavinck J.N. , Rácz E. , Kanitakis J. , Harwood C.A. , Cetkovská P. , Geusau A. , del Marmol V. , Masferrer E. , Orte Cano C. , Ricar J. , de Oliveira W.R. , Salido‐Vallejo R. , Ducroux E. , Gkini M.A. , López‐Guerrero J.A. , Kutzner H. , Kempf W. , Seçkin D. 
Published: May 2022

AbstractBackgroundThe proportion of Merkel cell carcinomas (MCCs) in solid‐organ transplant recipients (SOTR) harbouring Merkel cell polyomavirus (MCPyV) is unknown, as are factors affecting their outcomes.ObjectiveTo describe clinicopathological features of MCC in SOTR, investigate the tumoral MCPyV‐status and identify factors associated with tumour outcomes.MethodsRetrospective, international, cohort‐study. MCPyV‐status was investigated by immunohistochemistry and polymerase chain reaction.ResultsA total of 30 SOTR and 44 consecutive immunocompetent patients with MCC were enrolled. SOTR were younger at diagnosis (69 vs. 78 years, P < 0.001). Thirty‐three percent of SOTR MCCs were MCPyV‐positive vs. 91% of immunocompetent MCCs (P = 0.001). Solid‐organ transplantation was associated with an increased cumulative incidence of progression (SHR: 3.35 [1.57–7.14], P = 0.002), MCC‐specific mortality (SHR: 2.55 [1.07–6.06], P = 0.034) and overall mortality (HR: 3.26 [1.54–6.9], P = 0.002). MCPyV‐positivity and switching to an mTOR inhibitor (mTORi) after MCC diagnosis were associated with an increased incidence of progression (SHR: 4.3 [1.5–13], P = 0.008 and SHR: 3.6 [1.1–12], P = 0.032 respectively) in SOTR.LimitationsRetrospective design and heterogeneity of SOTR cohort.ConclusionsMCPyV appears to play a less prominent role in the aetiopathogenesis of MCC in SOTR. SOTR have a worse prognosis than their immunocompetent counterparts and switching to an mTORi after the diagnosis of MCC does not improve progression.
DNA barcoding and species delimitation of the genus Oxynoemacheilus (Teleostei: Nemacheilidae) in Anatolia
Authors: Bektas Yusuf , Aksu İsmail , Kaya Cüneyt , Bayçelebi Esra , Turan Davut 
Published: May 2022

AbstractThe DNA barcoding approach was used for the determination of evolutionary relationships and species delimitation of the genus Oxynoemacheilus (Teleostei: Nemacheilidae). The COI barcode region (615 bp amplicon) was used to barcode 444 individuals from 64 morphologically identified species in the genus Oxynoemacheilus and 189 haplotypes were identified. The average of the interspecific p distance (9.59%) was about 21‐fold higher than the average intraspecific distance (0.44%). A general genetic threshold of 1.46% sequence divergence was defined for species delimitation. The multiple species delimitation methods (BCM, GMYC, bPTP and TCS) revealed a total of 62 molecular operational taxonomic units for 64 morphospecies with a new loach species from the BuyukMelen River. Neighbour‐joining, maximum likelihood and Bayesian inference analyses indicated that all haplotypes were clustered into 62 clades, which corresponded to Oxynoemacheilus species, with strong bootstrap support (≥95%). Furthermore, all samples grouped in concurrence with the taxonomic status of the species except for species groups (O. germencicus‐O. cinicus‐O. mesudae and O. leontinae‐O. namiri) that were showed intraspecific overlap in genetic diversity for COI‐based barcodes. In conclusion, our analyses indicate that COI‐based barcodes provide reliable species discrimination. Therefore, we currently recommend COI barcodes as the suitable barcode for genus Oxynoemacheilus.
Characterization of junctional structures in the gingival epithelium as barriers against bacterial invasion
Authors: Ko Yeon Kyeong , Hong Sujung , Kim Hyun Man , Liu Mengmeng , Moon Eunyoung , Kim Pilhan , Choi Youngnim 
Published: May 2022

AbstractBackground and objectiveAdherens junctions (AJs) and tight junctions (TJs) are known to play a crucial role in maintaining the physical barrier function of the epithelium. Here, we aimed to characterize the distribution of AJs and TJs throughout the gingival epithelium and to obtain insights into the physiological importance of these junctional structures.MethodsSections of mouse gingival tissue were examined using transmission electron microscopy (TEM) and bio‐high voltage electron microscopy tomography. The gingival sections were stained for E‐cadherin and JAM‐A as markers of AJs and TJs, respectively, and examined using confocal microscopy and lattice structured illumination microscopy. Bacteria within the gingival epithelium were examined using in situ hybridization.ResultsJunctional structures, including desmosomes, AJs, and TJs, were observed throughout the gingival epithelium. The expression levels of E‐cadherin were particularly low in the granular/keratinized layers of the oral epithelium (OE), while extremely low JAM‐A levels were detected in the granular/keratinized layers of the sulcular epithelium (SE). The three‐dimensional rendering of the junctional structures revealed that both AJs and TJs in the gingival epithelium formed discontinuous short bands or patches. Interestingly, strong bacterial signals were observed at the granular/keratinized layers of both SE and OE, but a few bacteria were detected within the junctional epithelium (JE) and the basal/spinous layers of the SE and OE.ConclusionsAJs and TJs form a discontinuous barrier throughout paracellular passage in the gingival epithelium; nevertheless, they seem to play an important role in defending against invading bacteria.
Ionized hypercalcemia in cats with azotemic chronic kidney disease (2012‐2018)
Authors: van den Broek Dirk Hendrik Nicolaas , Geddes Rebecca F. , Lötter Nicola S. , Chang Yu‐Mei , Elliott Jonathan , Jepson Rosanne E. 
Published: May 2022

AbstractBackgroundHypercalcemia is associated with chronic kidney disease (CKD) in cats, but studies assessing the physiologically relevant ionized calcium fraction are lacking.ObjectivesTo describe the prevalence and incidence rate of ionized hypercalcemia, and to explore predictor variables to identify cats at risk of ionized hypercalcemia in a cohort of cats diagnosed with azotemic CKD.AnimalsOne hundred sixty‐four client‐owned cats with azotemic CKD.MethodsVariables independently associated with ionized hypercalcemia at diagnosis of azotemic CKD were explored by binary logistic regression. Cats that were normocalcemic at diagnosis of azotemic CKD were followed over a 12‐month period or until ionized hypercalcemia occurred and baseline predictor variables for ionized hypercalcemia explored using Cox proportional hazards and receiver operating characteristic curve analysis.ResultsIonized hypercalcemia (median, 1.41 mmol/L; range, 1.38‐1.68) was observed in 33/164 (20%) cats at diagnosis of azotemic CKD and was associated with male sex, higher plasma total calcium and potassium concentrations, and lower plasma parathyroid hormone concentrations. Twenty‐five of 96 initially normocalcemic (26%) cats followed for minimum 90 days developed ionized hypercalcemia (median, 1.46 mmol/L; range, 1.38‐1.80) at a median of 140 days after diagnosis of azotemic CKD (incidence rate, 0.48 per feline patient‐year). Only body condition score was independently associated with incident ionized hypercalcemia.Conclusions and Clinical ImportanceThe occurrence of ionized hypercalcemia is high in cats with CKD. Continued monitoring of blood ionized calcium concentrations is advised.