bluuebunny/crossref_metadata_2025_split huggingface dataset:
Catalytic role of binary oxides (CuO and Al2O3) on hydrogen storage in MgH2
Authors: Jubair Ahammed , Rahman Md. Akhlakur , Khan Md. Maksudur Rahman , Rahman Md. Wasikur 
Published: June 2022

AbstractHydrogen sorption characteristics of magnesium hydride (MgH2) were enhanced by ball milling for 12 h under an inert atmosphere with the addition of 20 wt% Al2O3 and as prepared CuO. X‐ray diffraction (XRD) characterization and thermal gravimetric analyzer coupled with a mass spectrometer (TGA‐MS) of the ball milled samples were carried out to determine the H2 sorption reactions. Additionally, XRD data were analyzed using Rietveld method to identify the crystallographic properties. Ball milled MgH2 with β and γ allotrope mixtures were found with broad peaks in XRD indicating the as prepared samples are amorphous and strain, alongside bare additives. H2 sorption in MgH2 is greatly enhanced by the presence of CuO and Al2O3 binary oxides. TGA experiment demonstrated fast desorption kinetics for ball milled samples with the oxide additives. Particularly, MgH2 milled with CuO showed a more remarkable effect on desorption kinetics rather than Al2O3. It takes less than 10 min to desorb more than 5 wt% H2 at 623 K. The activation energy of H2 desorption was estimated for the mixtures by Kissinger method and the lowest value (65 kJ mol−1) was obtained for the MgH2/CuO mixture. A kinetic model has been proposed in the context to illustrate the complex mechanism of dehydrogenation of MgH2 with the additives. Finally, the addition of metal oxides influences H2 sorption characteristics of MgH2 through lowering the activation energy and reducing the waste of energy for diffusing the thin layer of Mg that creates a pathway to store H2 within the system.
Petrology and geochronology of sapphirine‐bearing granulites from the Limpopo Complex in eastern Botswana: Implications for Palaeoproterozoic long‐lived high‐pressure/ultrahigh‐temperature metamorphism and rapid exhumation
Authors: Basupi Thembiso O. , Tsunogae Toshiaki , Tsutsumi Yukiyasu 
Published: June 2022

The Limpopo Complex in southern Africa is a classic example of Neoarchean collisional orogens with a Palaeoproterozoic thermal overprint. We report new petrological, pressure–temperature (P–T), and geochronological data of sapphirine‐bearing Mg–Al‐rich and pelitic granulites from a metasupracrustal unit (the Beit Bridge Complex [BBC]) in the eastern part of Botswana to constrain its P–T–time evolution. Textural observations and phase equilibria modelling of the peak mineral assemblage of Mg–Al‐rich granulites (K‐feldspar + orthopyroxene [Opx2; Al2O3 up to 8.8 wt.%] + sillimanite [Sil2] + quartz + rutile + biotite [Bt2] + inferred melt) in the NCKFMASHTO system recorded a peak metamorphic condition of >930°C and > 10.3 kbar. A pelitic granulite recorded consistent P–T conditions of 960–980°C and > 10.3 kbar, indicating high‐pressure (HP) and ultrahigh‐temperature (UHT) metamorphism for the BBC in Botswana. Post‐peak retrograde conditions were obtained based on the stability of sapphirine + cordierite symplectite assemblage in the Mg–Al‐rich rocks (820–860°C and 6.4–7.0 kbar) and orthopyroxene [Opx3] + cordierite symplectite assemblage in the pelitic granulite (830–930°C and 4.3–5.8 kbar), indicating near‐isothermal decompression after the peak HP–UHT metamorphism along a clockwise P–T path. Similar HP–UHT metamorphism followed by a near‐isothermal decompression along a clockwise P–T path was reported from different regions of the BBC in South Africa and Zimbabwe (P > 14 kbar and ~1,000°C based on the stability fields of magnesian staurolite and sapphirine + quartz assemblage), although the peak P–T condition is slightly lower in Botswana. Monazite grains with patchy zoning show isochron ages of 2,115 ± 77 Ma for Th‐poor domains, and 2,058 ± 40 Ma and 2,033 ± 34 Ma for Th‐rich domains. Similar ages were obtained from zircon U–Pb geochronology as 2,232–2,135 Ma and 2,010 ± 19 Ma (Th/U = 0.05–0.26). The younger ages (2.0 Ga) probably indicate the timing of near‐peak high‐grade event, while the older ages might indicate a thermal event during the prograde heating stage. The P–T conditions and zircon/monazite ages suggest Palaeoproterozoic long‐lived metamorphism associated with intracontinental transpressional tectonics related to Palaeoproterozoic orogenic events around the united Zimbabwe–Kaapvaal Craton.
Cognitive impairment, perceived medication adherence, and high‐risk medication use in patients with reduced kidney function: A cross‐sectional analysis
Authors: Sheets Kerry M. , Davey Cynthia S. , St. Peter Wendy L. , Reule Scott A. , Murray Anne M. 
Published: June 2022

AbstractBackground and AimsReduced estimated glomerular filtration rate (eGFR < 60 ml/min/1.73 m2) is a risk factor for cognitive impairment (CI) and medication nonadherence. However, the association between CI and medication adherence in adults with reduced eGFR has not been adequately examined. Our pragmatic objectives were to assess the cross‐sectional relationship between CI and self‐reported medication adherence, medication number, and use of potentially high‐risk medications among adults with reduced eGFR.MethodsAn observational cohort study of the epidemiology of CI in community‐dwelling adults aged 45 years or older with reduced eGFR.ResultsOur analytic cohort consisted of 420 participants (202 with CI; mean age: 69.7 years) with reduced eGFR, at least one prescription medication, and nonmissing medication adherence data. Participants with CI had four times greater unadjusted odds of reporting good medication adherence than participants without CI (self‐report of missing medications <4 days/month; odds ratio [OR]: 4.04, 95% confidence interval [CI]:​​​​​ 1.62–10.10). This difference persisted following adjustment for demographic factors and comorbidities (OR: 5.50, 95% CI: 1.86–16.28). Participants with CI were no more likely than participants without CI to report forgetfulness as a reason for missing medication doses. Participants with CI were, on average, taking more total (mean: 13.3 vs. 11.5, median: 12 vs. 11) and more high‐risk (mean: 5.0 vs. 4.2, median: 5 vs. 4) medications than those without CI; these differences were attenuated and no longer significant following adjustment for demographics and comorbidities.ConclusionGiven the well‐documented association between CI and medication nonadherence, better self‐reported medication adherence among those with CI may represent perceptions of adherence rather than actual adherence. Participants with CI were, on average, taking more total and more high‐risk medications than those without CI, suggesting a possible increased risk for adverse drug events. Our results highlight the potential risks of relying on self‐reported medication adherence in reduced eGFR patients with CI.
Reference prices and withdrawn acquisitions
Authors: Lai Shaojie , Pu Xiaoling , Wang Qing (Sophie) , Zhang Jianing 
Published: June 2022

AbstractUsing a sample of 1525 withdrawn deals from 1981 to 2015 in the United States, we find that target firms close to their 52‐week high prices after merger announcements have lower withdrawal probabilities. The effect is different across merger waves. The out‐wave deals are sensitive to the target reference prices while in‐wave deals are not. Moreover, targets with post‐announcement prices close to 52‐week high tend to have higher withdrawn returns and receive higher adjustments of offering prices in renegotiation. Overall, our results suggest that target post‐announcement stock prices significantly affect deal outcomes.
Robotic‐assisted laparoscopic removal of dermoid cyst mimicking an enlarged cystic mass in the seminal vesicle
Authors: Lascano Danny , Hsieh Kelly , Kedia Bhuvi , Higgins John P , Chung Benjamin I 
Published: June 2022

IntroductionIsolated seminal vesicle cysts not associated with Zinner syndrome is a rare disorder that can present initially with urinary obstructive symptoms or nonspecific groin pain.Case descriptionWe present the uncommon case of a dermoid cyst mimicking a seminal vesicle cyst treated with robotic‐assisted laparoscopic seminal vesiculectomy.ConclusionFor dermoid cysts, surgical excision is the gold standard of treatment with a high cure rate and little risk of regrowth if spillage is avoided and full resection is completed. Robotic‐assisted laparoscopic surgery is a viable management option with good visualization of the anatomy.
Liesegang rings in the setting of end‐stage renal disease
Authors: Gross Alexander R , Amin Shahrier , Jelic Tomislav 
Published: June 2022

IntroductionLiesegang rings are acellular, lamellar, concentric rings of organic or inorganic material naturally formed in both biologic and environmental systems. Description in human tissue is scarce. Liesegang rings have exclusively been identified in association with pathologic disease processes and thus are not typically considered in differential diagnosis. They are usually described with cystic or inflammatory lesions. Histologically, Liesegang rings show features that are also seen in sections of parasitic ova, larvae, psammoma bodies, and by radiology as calcifications in cystic diseases of the breast and kidney.Case presentationWe noted at autopsy of a 59‐year‐old diabetic woman multiple black “stones” in the renal medulla. Microscopic examination demonstrated these to contain Liesegang rings.ConclusionLiesegang rings formation should be considered in the differential diagnosis of atypical appearing deposits in the kidneys and other tissues. They may play a role in the pathogenesis of kidney stones.
Modified foreign body reaction to silicone imbedded in subcutaneous tissues by different mouse systemic immune conditions
Authors: Yamakawa Tomohiro , Ichii Osamu , Nakamura Teppei , Namba Takashi , Elewa Yaser Hosny Ali , Masum Md. Abdul , Otani Yuki , Nishimura Takanori , Kon Yasuhiro 
Published: June 2022

AbstractForeign body reaction (FBR) causes unexpected adverse effects due to implanted materials in humans and animals. Inflammation and subsequent fibrosis during FBR seems to be affected by recipient immunity, such as the balance of T helper (Th) response that has the potential to regulate FBR‐related macrophage function. Here, the immunological effects of FBR on subcutaneously imbedded silicone tubes (ST) at 8 weeks were investigated histologically by comparing Th1‐biased C57BL/6N, Th2‐biased MRL/MpJ, and autoimmune disease‐prone MRL/MpJ‐Faslpr/lpr. Tissue surrounding ST (TSS) was analyzed at day (D) 7 and 14 (reaction phase) or D35 (stability phase) after surgery. In all strains, the TSS was composed of a thin layer (TL) containing fibrous tissues and loose connective tissues formed outside the TL. Few lymphocytes and mast cells, several neutrophils, and numerous macrophages infiltrated the TSS. Active vascularization was observed at D14 in all strains. For the examined indices, M1‐type macrophage density in the TSS of C57BL/6N mice was significantly higher at D14 compared to other strains. No significant strain difference relating to M2‐type macrophages was detected, suggesting the effects of Th1‐biased immunity on FBR‐related inflammation. Collagen fibers in the TSS increased in density and became stable with age in all strains. In particular, MRL/MpJ‐Faslpr/lpr showed progressive fibrotic features. Serum autoantibody levels in MRL/MpJ‐Faslpr/lpr mice were inversely correlated with M1‐type macrophage density. These data from MRL/MpJ‐Faslpr/lpr mice suggested modifications of FBR‐related inflammation and fibrosis by autoimmune abnormalities. The results provide crucial insights into the pathological modification of FBR by recipient immunity and emphasize its clinicopathological importance in humans and animals.
Reviving human γδT cells from apoptosis induced by IL-12/18 via p-JNK inhibition
Authors: Song Yuan , Teo Huey Yee , Liu Yonghao , Zhang Xiaomeng , Chen Jinmiao , Zhang Yongliang , Liu Haiyan 
Published: June 2022

AbstractγδT cells recognize and exert cytotoxicity against tumor cells independently of MHC restriction and have antigen presentation and regulatory functions to promote adaptive immune responses. They are considered as potential immune cells for cellular immunotherapy in cancer patients. However, it is challenging to ex vivo expand human γδT cells that have superb effector functions and long-term survival for adoptive cancer therapy. We found that IL-12/18 combination could drastically promote IFN-γ secretion and cytotoxicity in human γδT cells. However, the enhanced activation of human γδT cells is accompanied by increased apoptosis and elevated expressions of co-inhibitory receptors under the stimulation of IL-12/18. We further demonstrated that IL-12/18 induced apoptosis of human γδT cells was in a phosphoantigen or IFN-γ-independent manner. Transcriptomic analysis suggested that IL-12/18-induced apoptosis of human γδT cells was mediated by the activation of JNK pathway. p-JNK inhibitor (SP-600125) treatment effectively revived human γδT cells from the apoptosis induced by IL-12/18 and maintained their enhanced IFN-γ production and cytotoxicity against tumor cells. Our results provide a novel and feasible strategy for ex vivo expansion of cytokine-activated human γδT cells, which could promote the efficacy of γδT cell adoptive immunotherapy in cancer patients.
Historical trends in climate indices relevant to surface air temperature and precipitation in Japan for recent 120 years
Authors: Nakaegawa Tosiyuki , Murazaki Kazuyo 
Published: June 2022

AbstractGeographical distributions of trends in climate indices with statistical significance in Japan are investigated at each of the 51 observation stations for the recent 120 years. We employed a comprehensive set of the 70 climate indices on an annual timescale to detect climate changes and to facilitate climate information for a variety of sectors, which are developed by expert team on sector‐specific indices in the World Meteorological Organization. The rising trends have regional differences such as the annual mean of daily maximum and minimum surface air temperatures in the Kanto‐Koushin region. The statistically significant increasing trends in three daily heavy precipitation‐relevant climate indices, R95p, R99p, and RX1day, are seen in Hokuriku, Shikoku, the western part of Northern and Southern Kyusyu regions, and isolated stations in the other regions. Rotational empirical orthogonal function analysis of R99p revealed different features of statistically significant modes suggesting the trends are attributed to changes in different atmospheric phenomena as well as those of warm spell duration index. The number of the stations with statistically significant trends varies with an index. Indies relevant to daily minimum surface air temperatures have statistically significant trends at most of the 51 stations. Consecutive dry days are the most sensitive to climate changes for the 120 years among the indices relevant to precipitation in this analysis. The indices relevant to heavy precipitation are not always been most sensitive to climate change detections in Japan. The geographical distributions of the percentage of the number of indices with statistically significant changes to the total number of the stations provide information about stations sensitive to climate changes. The highest sensitivity is seen at Kumamoto. These results directly provide detection of climate changes and show the potentials of which index is sensitive to ongoing climate changes from the viewpoint of geographical distributions.
Parametric Nonlinear Optics with Layered Materials and Related Heterostructures
Authors: Dogadov Oleg , Trovatello Chiara , Yao Baicheng , Soavi Giancarlo , Cerullo Giulio 
Published: June 2022

AbstractNonlinear optics is of crucial importance in several fields of science and technology with applications in frequency conversion, entangled‐photon generation, self‐referencing of frequency combs, crystal characterization, sensing, and ultra‐short light pulse generation and characterization. In recent years, layered materials and related heterostructures have attracted huge attention in this field, due to their huge nonlinear optical susceptibilities, their ease of integration on photonic platforms, and their 2D nature which relaxes the phase‐matching constraints and thus offers a practically unlimited bandwidth for parametric nonlinear processes. In this review the most recent advances in this field, highlighting their importance and impact both for fundamental and technological aspects, are reported and explained, and an outlook on future research directions for nonlinear optics with atomically thin materials is provided.
Humidity Responsive Reflection Grating Made by Ultrafast Nanoimprinting of a Hydrogel Thin Film
Authors: Cesnik Stefan , Perrotta Alberto , Cian Alessandro , Tormen Massimo , Bergmann Alexander , Coclite Anna Maria 
Published: June 2022

AbstractThe response time of state‐of‐the‐art humidity sensors is ≈8 s. A faster tracking of humidity change is especially required for health care devices. This research is focused on the direct nanostructuring of a humidity‐sensitive polymer thin film and it is combined with an optical read‐out method. The goal is to improve the response time by changing the surface‐to‐volume ratio of the thin film and to test a different measurement method compared to state‐of‐the‐art sensors. Large and homogeneous nanostructured areas are fabricated by nanoimprint lithography on poly(2‐hydroxyethyl methacrylate) thin films. Those thin films are made by initiated chemical vapor deposition (iCVD). To the author's knowledge, this is the first time nanoimprint lithography is applied on iCVD polymer thin films. With the imprinting process, a diffraction grating is developed in the visible wavelength regime. The optical and physicochemical behavior of the nanostructures is modeled with multi‐physic simulations. After successful modeling and fabrication a first proof of concept shows that humidity dependency by using an optical detection of the first diffraction order peak is observable. The response time of the structured thin film results to be at least three times faster compared to commercial sensors.
Chicken Muscle Protein‐Derived Peptide VVHPKESF Reduces TNFα‐Induced Inflammation and Oxidative Stress by Suppressing TNFR1 Signaling in Human Vascular Endothelial Cells
Authors: Fan Hongbing , Bhullar Khushwant S. , Wang Zihan , Wu Jianping 
Published: June 2022

ScopeThis study aims to investigate the protective effects of four chicken muscle‐derived peptides Val‐Arg‐Pro (VRP), Leu‐Lys‐Tyr (LKY), Val‐Arg‐Tyr (VRY), and Val‐Val‐His‐Pro‐Lys‐Glu‐Ser‐Phe [VVHPKESF (V‐F)] on tumor necrosis factor alpha (TNFα)‐induced endothelial inflammation and oxidative stress in human vascular endothelial EA.hy926 cells.Methods and resultsInflammation and oxidative stress are induced in EA.hy926 cells by TNFα (10 ng mL−1) treatment for different periods of time. Inflammatory proteins and signaling molecules including inducible nitric oxide synthase, intracellular cell adhesion molecule‐1, vascular cell adhesion molecule‐1 (VCAM‐1), cyclooxygenase 2 (COX2), nuclear factor kappa B (NF‐κB), mitogen‐activated protein kinases (MAPKs), and TNFα receptor 1 (TNFR1) are measured by qRT‐PCR or western blotting; soluble TNFR1 level and nicotinamide adenine dinucleotide phosphate NADPH) oxidase activity are determined by Elisa kits; superoxide is measured by dihydroethidium staining. Only V‐F treatment inhibits the expression of VCAM‐1 and COX2, via suppressing NF‐κB and p38 MAPK signaling, respectively, while reduced oxidative stress via the inhibition of NADPH oxidase activity; V‐F treatment attenuates both gene and protein expressions of TNFR1.ConclusionV‐F treatment ameliorates TNFα‐induced endothelial inflammation and oxidative stress likely via the inhibition of TNFR1 signaling, suggesting its potential as a functional food ingredient or nutraceutical in the prevention and treatment of hypertension and cardiovascular diseases.
Quantification of lung function on CT images based on pulmonary radiomic filtering
Authors: Yang Zhenyu , Lafata Kyle J. , Chen Xinru , Bowsher James , Chang Yushi , Wang Chunhao , Yin Fang‐Fang 
Published: June 2022

AbstractPurposeTo develop a radiomics filtering technique for characterizing spatial‐encoded regional pulmonary ventilation information on lung computed tomography (CT).MethodsThe lung volume was segmented on 46 CT images, and a 3D sliding window kernel was implemented across the lung volume to capture the spatial‐encoded image information. Fifty‐three radiomic features were extracted within the kernel, resulting in a fourth‐order tensor object. As such, each voxel coordinate of the original lung was represented as a 53‐dimensional feature vector, such that radiomic features could be viewed as feature maps within the lungs. To test the technique as a potential pulmonary ventilation biomarker, the radiomic feature maps were compared to paired functional images (Galligas PET or DTPA‐SPECT) based on the Spearman correlation (ρ) analysis.ResultsThe radiomic feature maps GLRLM‐based Run‐Length Non‐Uniformity and GLCOM‐based Sum Average are found to be highly correlated with the functional imaging. The achieved ρ (median [range]) for the two features are 0.46 [0.05, 0.67] and 0.45 [0.21, 0.65] across 46 patients and 2 functional imaging modalities, respectively.ConclusionsThe results provide evidence that local regions of sparsely encoded heterogeneous lung parenchyma on CT are associated with diminished radiotracer uptake and measured lung ventilation defects on PET/SPECT imaging. These findings demonstrate the potential of radiomics to serve as a complementary tool to the current lung quantification techniques and provide hypothesis‐generating data for future studies.
Dietary acid load and risk of head and neck and oral cavity cancers: An epidemiologic study
Authors: Ronco Alvaro L. , Martínez‐López Wilner , Calderón Juan M. , Storz Maximilian A. 
Published: June 2022

AbstractAimMetabolic acidosis subsequent to a high dietary acid load (DAL) leads to inflammation and cell transformation, which are common features of cancer development. Because the epidemiologic evidence associating DAL and cancer risk is still limited, we sought to explore the potential role of DAL as a risk factor for head and neck and oral cavity tumors.MethodsA case–control study was performed on 1126 men (563 cases and 563 age frequency and residence matched controls), drawn from the major public hospitals in Montevideo, Uruguay. Participants were interviewed through a multi‐topic questionnaire, including a food frequency questionnaire. Food‐derived nutrients were calculated from available databases. DAL was calculated based on validated measures including potential renal acid load (PRAL) and net endogenous acid production (NEAP) scores. Odds ratios (OR) were estimated by logistic regression, adjusting for potential confounders.ResultsWe found significant and direct associations between dietary acid load and risk of head and neck and oral cavity cancers (OR = 2.10 and OR = 1.95 for highest PRAL and NEAP, respectively). In addition, stratified analyses by subsites displayed the highest estimates for pharyngeal cancer (OR = 2.40 and OR = 2.28 for highest PRAL and NEAP, respectively). No association was found for oral cavity cancers.ConclusionsAn acidogenic diet may increase the risk of head and neck cancers. Our findings align well with our previous studies focused on other anatomic sites. Studies conducted on food groups and nutritional patterns align with our results. Further studies are needed to confirm these findings.