bluuebunny/crossref_metadata_2025_split huggingface dataset:
Deformation evolution depending on grain boundary type and hydrogen concentration in nickel investigated by molecular dynamics simulation
Authors: Zheng Yuanyuan , Cao Lili , Huang Jianghua , Zhang Lin 
Published: July 2022

Abstract
The impacts of hydrogen concentration on tensile deformation in the nickel bicrystals with different typical grain boundaries (GB) were investigated by molecular dynamics simulation. The deformation behavior was dependent on the GB type and hydrogen concentration. A critical hydrogen concentration was obtained from a drastic change of the theoretical yield strength. Below critical concentration, hydrogen increased the yield strength and the atomic rearrangement was effectively hindered due to uniform distribution of hydrogen. Above critical concentration, the nickel-hydride formed and caused a sharp decrease in yield strength, which was independent of the GB type.
Microstructural, optical, and magnetic properties and specific absorption rate of bismuth ferrite/SiO2 nanoparticles
Authors: Juwita Erna , Sulistiani Fitria Ayu , Darmawan Mahardika Yoga , Istiqomah Nurul Imani , Suharyadi Edi 
Published: July 2022

Abstract
In this study, the microstructural, optical, and magnetic properties and specific absorption rate (SAR) of bismuth ferrite/SiO2 nanoparticles were successfully investigated. The coprecipitation method was used to synthesize the nanoparticles. X-ray diffraction patterns showed the presence of sillenite-type Bi25FeO40 with a body-centered cubic structure. The crystallite size of Bi25FeO40 was 35.0 nm, which increased to 41.5 nm after SiO2 encapsulation. Transmission electron microscopy images confirmed that all samples were polycrystalline. The presence of Si–O–Si (siloxane) stretching at 1089 cm−1 in Fourier transform infrared spectra confirmed the encapsulation of SiO2. Magnetic measurements at room temperature indicated weak ferromagnetic properties of the samples. The coercivity of the bismuth ferrite nanoparticles was 78 Oe, which increased after SiO2 encapsulation. In contrast, their maximum magnetization, 0.54 emu g−1, reduced after SiO2 encapsulation. The determined bandgap energy of the bismuth ferrite nanoparticles was approximately 2.1 eV, which increased to 2.7 eV after SiO2 encapsulation. The effect of SiO2 encapsulation on the SAR of the samples was investigated using a calorimetric method. The SAR values of the bismuth ferrite nanoparticles were 49, 61, and 84 mW g−1 under alternating magnetic field (AMF) strengths of 150, 200, and 250 Oe, respectively, which decreased after SiO2 encapsulation. The maximum magnetization and the AMF strength influenced the SAR of the nanoparticles. The results showed that SiO2 has a significant effect in determining the microstructural, optical, and magnetic properties and SAR of the nanoparticles.
Contexts and contradictions: a roadmap for computational drug repurposing with knowledge inference
Authors: Sosa Daniel N , Altman Russ B 
Published: July 2022

Abstract
The cost of drug development continues to rise and may be prohibitive in cases of unmet clinical need, particularly for rare diseases. Artificial intelligence-based methods are promising in their potential to discover new treatment options. The task of drug repurposing hypothesis generation is well-posed as a link prediction problem in a knowledge graph (KG) of interacting of drugs, proteins, genes and disease phenotypes. KGs derived from biomedical literature are semantically rich and up-to-date representations of scientific knowledge. Inference methods on scientific KGs can be confounded by unspecified contexts and contradictions. Extracting context enables incorporation of relevant pharmacokinetic and pharmacodynamic detail, such as tissue specificity of interactions. Contradictions in biomedical KGs may arise when contexts are omitted or due to contradicting research claims. In this review, we describe challenges to creating literature-scale representations of pharmacological knowledge and survey current approaches toward incorporating context and resolving contradictions.
The behavioral sensitivity of mice to acetate esters
Authors: Jennings Liam , Williams Ellie , Avlas Marta , Dewan Adam 
Published: July 2022

Abstract
Measures of behavioral sensitivity provide an important guide for choosing the stimulus concentrations used in functional experiments. This information is particularly valuable in the olfactory system as the neural representation of an odorant changes with concentration. This study focuses on acetate esters because they are commonly used to survey neural activity in a variety of olfactory regions, probe the behavioral limits of odor discrimination, and assess odor structure–activity relationships in mice. Despite their frequent use, the relative sensitivity of these odorants in mice is not available. Thus, we assayed the ability of C57BL/6J mice to detect seven different acetates (propyl acetate, butyl acetate, pentyl acetate, hexyl acetate, octyl acetate, isobutyl acetate, and isoamyl acetate) using a head-fixed Go/No-Go operant conditioning assay combined with highly reproducible stimulus delivery. To aid in the accessibility and applicability of our data, we have estimated the vapor-phase concentrations of these odorants in five different solvents using a photoionization detector-based approach. The resulting liquid-/vapor-phase equilibrium equations successfully corrected for behavioral sensitivity differences observed in animals tested with the same odorant in different solvents. We found that mice are most sensitive to isobutyl acetate and least sensitive to propyl acetate. These updated measures of sensitivity will hopefully guide experimenters in choosing appropriate stimulus concentrations for experiments using these odorants.
Deliberating alone: deliberative bias and giving up on political talk
Authors: McLaughlin Bryan , Wilkinson Kenton T , Rendon Hector , Martinez T J 
Published: July 2022

AbstractIn our research examining how people think and talk about immigration, we consistently find that people want to have a reasonable conversation about politics, but they often decide that productive conversations are not possible because other people are uninformed, irrational, close-minded, and uncivil. We argue that self-serving biases and phenomenological experiences lead to the biased perception that the self is far more capable of adhering to the ideals of rational deliberation than others, a process that we refer to as deliberative bias. In Study 1, we use data from in-depth interviews to develop the concept of deliberative bias. In Study 2, we use a survey to demonstrate that perceptions that other people are uninformed, irrational, close-minded, and uncivil are related to a decreased likelihood of talking politics with loose ties or those with opposing perspectives. These results suggest that deliberative bias may be a significant impediment to productive political conversations.
Whose Victims and Whose Survivors? Polish Jewish Refugees between Holocaust and Gulag Memory Cultures
Authors: Zessin-Jurek Lidia 
Published: July 2022

ABSTRACT
Holocaust and Gulag studies are witnessing the belated emergence of the Soviet experience of Jewish escapees from Nazi-occupied Poland as a lieu de mémoire in its own right. Although not commemorated in official ritual, museum spaces, or memorial sites, the sheer mass of published testimonies by survivors of this experience far outweighs the previous lack of attention to the refugees’ story. It was the agency of the refugee survivors themselves which subsequently put their Soviet experience on the mnemonic map of World War II. This article discusses both the reasons for that lack of attention and the current growing interest in their accounts. It proposes a typology based on questions of victimhood and perpetratorship, analyzed through the contrast between the way the Jewish exiles in the USSR interpreted their experiences and how those who experienced the Holocaust directly interpreted theirs. The article thus asks, whose victims did the refugees consider themselves, the Germans’ or the Soviets’?
Ceftriaxone dosing based on the predicted probability of augmented renal clearance in critically ill patients with pneumonia
Authors: Dreesen Erwin , Gijsen Matthias , Elkayal Omar , Annaert Pieter , Debaveye Yves , Wauters Joost , Karlsson Mats O , Spriet Isabel 
Published: July 2022

Abstract

Objectives
PTA of protein-unbound ceftriaxone may be compromised in critically ill patients with community-acquired pneumonia (CAP) with augmented renal clearance (ARC). We aimed to determine an optimized ceftriaxone dosage regimen based on the probability of developing ARC on the next day (PARC,d+1; www.arcpredictor.com).

Patients and methods
Thirty-three patients enrolled in a prospective cohort study were admitted to the ICU with severe CAP and treated with ceftriaxone 2 g once daily. Patients contributed 259 total ceftriaxone concentrations, collected during 1 or 2 days (±7 samples/day). Unbound fractions of ceftriaxone were determined in all peak and trough samples (n = 76). Population pharmacokinetic modelling and simulation were performed using NONMEM7.4. Target attainment was defined as an unbound ceftriaxone concentration &gt;4 mg/L throughout the dosing interval.

Results
A two-compartment population pharmacokinetic model described the data well. The maximal protein-bound ceftriaxone concentration decreased with lower serum albumin. Ceftriaxone clearance increased with body weight and PARC,d+1 determined on the previous day. A high PARC,d+1 was identified as a clinically relevant predictor for underexposure on the next day (area under the receiver operating characteristics curve 0.77). Body weight had a weak predictive value and was therefore considered clinically irrelevant. Serum albumin had no predictive value. An optimal PARC,d+1 threshold of 5.7% was identified (sensitivity 73%, specificity 69%). Stratified once- or twice-daily 2 g dosing when below or above the 5.7% PARC,d+1 cut-off, respectively, was predicted to result in 81% PTA compared with 47% PTA under population-level once-daily 2 g dosing.

Conclusions
Critically ill patients with CAP with a high PARC,d+1 may benefit from twice-daily 2 g ceftriaxone dosing for achieving adequate exposure on the next day.
Up-regulation of LsKN1 promotes cytokinin and suppresses gibberellin biosynthesis to generate wavy leaves in lettuce
Authors: Jia Yue , Yu Pei , Shao Wei , An Guanghui , Chen Jiongjiong , Yu Changchun , Kuang Hanhui 
Published: July 2022

Abstract
Lettuce (Lactuca sativa) is one of the most popular vegetables worldwide, and diverse leaf shapes, including wavy leaves, are important commercial traits. In this study, we examined the genetics of wavy leaves using an F2 segregating population, and identified a major QTL controlling wavy leaves. The candidate region contained LsKN1, which has previously been shown to be indispensable for leafy heads in lettuce. Complementation tests and knockout experiments verified the function of LsKN1 in producing wavy leaves. The LsKN1∇ allele, which has the insertion of a transposon and has previously been shown to control leafy heads, promoted wavy leaves in our population. Transposition of the CACTA transposon from LsKN1 compromised its function for wavy leaves. High expression of LsKN1 up-regulated several key genes associated with cytokinin (CK) to increase the content in the leaves, whereas it down-regulated the expression of genes in the gibberellin (GA) biosynthesis pathway to decrease the content. Application of CK to leaves enhanced the wavy phenotype, while application of GA dramatically flattened the leaves. We conclude that the changes in CK and GA contents that result from high expression of LsKN1 switch determinate cells to indeterminate, and consequently leads to the development of wavy leaves.
Hydromagnetic waves in an expanding universe – cosmological MHD code tests using analytic solutions
Authors: Berlok Thomas 
Published: July 2022

ABSTRACTWe describe how analytic solutions for linear hydromagnetic waves can be used for testing cosmological magnetohydrodynamic (MHD) codes. We start from the comoving MHD equations and derive analytic solutions for the amplitude evolution of linear hydromagnetic waves in a matter-dominated, flat Einstein-de-Sitter (EdS) universe. The waves considered are comoving, linearly polarized Alfvén waves and comoving, magnetosonic (fast) waves modified by self-gravity. The solution for compressible waves is found for a general adiabatic index and we consider the limits of hydrodynamics without self-gravity in addition to the full solution. In addition to these analytic solutions, the linearized equations are solved numerically for a Λ cold dark matter cosmology. We use the analytic and numeric solutions to compare with results obtained using the cosmological MHD code arepo and find good agreement when using a sufficient number of grid points. We interpret the numerical damping clearly evident in simulations with few grid points by further deriving the Alfvén wave solution including physical Navier–Stokes viscosity. A comparison between Alfvén wave simulations and theory reveals that the dissipation can be described by a numerical viscosity coefficient ηnum ∝ a−5/2, where a is the scale factor. We envision that our examples could be useful when developing a new cosmological MHD code or for regression testing of existing codes.
Transparency of fast radio burst waves in magnetar magnetospheres
Authors: Qu Yuanhong , Kumar Pawan , Zhang Bing 
Published: July 2022

ABSTRACT
At least some fast radio bursts (FRBs) are produced by magnetars. Even though mounting observational evidence points towards a magnetospheric origin of FRB emission, the question of the location for FRB generation continues to be debated. One argument suggested against the magnetospheric origin of bright FRBs is that the radio waves associated with an FRB may lose most of their energy before escaping the magnetosphere because the cross-section for e± to scatter large-amplitude electromagnetic waves in the presence of a strong magnetic field is much larger than the Thompson cross-section. We have investigated this suggestion and find that FRB radiation travelling through the open field line region of a magnetar’s magnetosphere does not suffer much loss due to two previously ignored factors. First, the plasma in the outer magnetosphere ($r \gtrsim 10^9$ cm), where the losses are potentially most severe, is likely to be flowing outwards at a high Lorentz factor γp ≥ 103. Secondly, the angle between the wave vector and the magnetic field vector, θB, in the outer magnetosphere is likely of the order of 0.1 radian or smaller due in part to the intense FRB pulse that tilts open magnetic field lines so that they get aligned with the pulse propagation direction. Both these effects reduce the interaction between the FRB pulse and the plasma substantially. We find that a bright FRB with an isotropic luminosity $L_{\rm frb} \gtrsim 10^{42} \, {\rm erg \ s^{-1}}$ can escape the magnetosphere unscathed for a large section of the γp − θB parameter space, and therefore conclude that the generation of FRBs in magnetar magnetosphere passes this test.
Detectability of wandering intermediate-mass black holes in the Milky Way galaxy from radio to x-rays
Authors: Seepaul Bryan S , Pacucci Fabio , Narayan Ramesh 
Published: July 2022

ABSTRACT
Intermediate-mass black holes (IMBHs, $10^{3\!-\!6} \, {\rm M_\odot }$), are typically found at the centre of dwarf galaxies and might be wandering, thus far undetected, in the Milky Way (MW). We use model spectra for advection-dominated accretion flows to compute the typical fluxes, in a range of frequencies spanning from radio to X-rays, emitted by a putative population of $10^5 \, {\rm M_\odot }$ IMBHs wandering in five realistic volume-weighted MW environments. We predict that $\sim 27{{\ \rm per\ cent}}$ of the wandering IMBHs can be detected in the X-ray with Chandra, $\sim 37{{\ \rm per\ cent}}$ in the near-infrared with the Roman Space Telescope, $\sim 49{{\ \rm per\ cent}}$ in the sub-mm with CMB-S4, and $\sim 57{{\ \rm per\ cent}}$ in the radio with ngVLA. We find that the brightest fluxes are emitted by IMBHs passing through molecular clouds or cold neutral medium, where they are always detectable. We propose criteria to facilitate the selection of candidates in multiwavelength surveys. Specifically, we compute the X-ray to optical ratio (αox) and the optical to sub-mm ratio, as a function of the accretion rate of the IMBH. We show that at low rates the sub-mm emission of IMBHs is significantly higher than the optical, UV, and X-ray emission. Finally, we place upper limits on the number N• of these objects in the MW: N• &lt; 2000 and N• &lt; 100, based on our detectability expectations and current lack of detections in molecular clouds and cold neutral medium, respectively. These predictions will guide future searches of IMBHs in the MW, which will be instrumental to understanding their demographics and evolution.
The impact of one-parent family payment reforms on the labour market outcomes of lone parents
Authors: Redmond Paul , McGuinness Seamus , Keane Claire 
Published: July 2022

AbstractWe evaluate the impact of a reduction in the child qualifying age for the One-Parent Family Payment in Ireland. From 2012 to 2015, the child qualifying age was reduced from 18 to 7 years. Lone parents who no longer qualified for the payment, based on the age of their child, could avail of Jobseekers Transitional Payment, which involves a labour activation component. The reforms led to an increase in the average hours worked of lone parents of between 2 and 5 h per week. Lone parents impacted by the policy were 13 percentage points more likely to be working. In addition, we find an increase in household income of between 9% and 12%, and an increase of between 23% and 29% in earnings from employment. Finally, the policy was associated with a 10–14 percentage point reduction in the poverty rate of lone parents.
Primary cicatricial alopecias are characterized by dysregulation of shared gene expression pathways
Authors: Wang Eddy H C , Monga Isha , Sallee Brigitte N , Chen James C , Abdelaziz Alexa R , Perez-Lorenzo Rolando , Bordone Lindsey A , Christiano Angela M 
Published: July 2022

Abstract
The primary forms of cicatricial (scarring) alopecia (PCA) are a group of inflammatory, irreversible hair loss disorders characterized by immune cell infiltrates targeting hair follicles (HFs). Lichen planopilaris (LPP), frontal fibrosing alopecia (FFA), and centrifugal cicatricial alopecia (CCCA) are among the main subtypes of PCAs. The pathogenesis of the different types of PCAs are poorly understood, and current treatment regimens yield inconsistent and unsatisfactory results. We performed high-throughput RNA-sequencing on scalp biopsies of a large cohort PCA patients to develop gene expression-based signatures, trained into machine-learning-based predictive models and pathways associated with dysregulated gene expression. We performed morphological and cytokine analysis to define the immune cell populations found in PCA subtypes. We identified a common PCA gene signature that was shared between LPP, FFA, and CCCA, which revealed a significant over-representation of mast cell (MC) genes, as well as downregulation of cholesterogenic pathways and upregulation of fibrosis and immune signaling genes. Immunohistological analyses revealed an increased presence of MCs in PCAs lesions. Our gene expression analyses revealed common pathways associated with PCAs, with a strong association with MCs. The indistinguishable differences in gene expression profiles and immune cell signatures between LPP, FFA, and CCCA suggest that similar treatment regimens may be effective in treating these irreversible forms of hair loss.
Examination of nailfold videocapillaroscopy findings in ANCA-associated vasculitis
Authors: Matsuda Shogo , Kotani Takuya , Wakura Reiko , Suzuka Takayasu , Kuwabara Hiroko , Kiboshi Takao , Wada Yumiko , Shiba Hideyuki , Hata Kenichiro , Shoda Takeshi , Hirose Yoshinobu , Takeuchi Tohru 
Published: July 2022

Abstract

Objective
The objective of this study was to evaluate nailfold videocapillaroscopy (NVC) as a useful tool for assessing the disease activity of ANCA-associated vasculitis (AAV).

Methods
This study enrolled 51 patients with AAV and 21 healthy controls. We scored NVC findings semiquantitatively, and compared them between AAV patients and controls. We examined the association of NVC findings with disease activity indicators, histopathological findings of skin biopsies, and high-resolution CT (HRCT) scores in AAV. Additionally, we repeatedly rated the NVC findings 3 months after immunosuppressive therapy.

Results
Of the 51 enrolled patients, 36 (70.6%) showed a microangiopathy pattern and 4 (7.8%) showed a scleroderma pattern in AAV. The scores for microhaemorrhage, capillary loss, neoangiogenesis, and tortuosity were significantly higher in the AAV group than in the control group. NVC abnormalities correlated with the severity of skin, lung and kidney involvement. The scores of giant capillaries significantly correlated with the total BVAS and the chest BVAS; the scores of capillary loss correlated with the chest BVAS and the renal BVAS. The scores of microhaemorrhage significantly correlated with perivascular inflammatory cell infiltrations in the upper dermis of the purpura and tended to correlate with the total ground-glass opacity and consolidation scores on HRCT. In addition, capillary loss scores had a significant positive correlation with serum creatinine levels. Additionally, the microhaemorrhage scores were significantly reduced after 3 months of immunosuppressive therapy.

Conclusion
In AAV patients, NVC abnormalities are significantly associated with disease severity. This result suggests that NVC is a useful tool for assessing the disease activity and treatment response in AAV.
Rhizomania: Hide and Seek of Polymyxa betae and the Beet Necrotic Yellow Vein Virus with Beta vulgaris
Authors: Decroës Alain , Mahillon Mathieu , Genard Margaux , Lienard Charlotte , Lima-Mendez Gipsi , Gilmer David , Bragard Claude , Legrève Anne 
Published: July 2022

The molecular interactions between Polymyxa betae, the protist vector of sugar beet viruses, beet necrotic yellow vein virus (BNYVV), the causal agent of rhizomania, and Beta vulgaris have not been extensively studied. Here, the transmission of BNYVV to sugar beet by P. betae zoospores was optimized using genetically characterized organisms. Molecular interactions of aviruliferous and viruliferous protist infection on sugar beet were highlighted by transcriptomic analysis. P. betae alone induced limited gene expression changes in sugar beet, as a biotrophic asymptomatic parasite. Most differentially expressed plant genes were down-regulated and included resistance gene analogs and cell wall peroxidases. Several enzymes involved in stress regulation, such as the glutathione- S-transferases, were significantly induced. With BNYVV, the first stages of the P. betae life cycle on sugar beet were accelerated with a faster increase of relative protist DNA level and an earlier appearance of sporangia and sporosori in plants roots. A clear activation of plant defenses and the modulation of genes involved in plant cell wall metabolism were observed. The P. betae transcriptome in the presence of BNYVV revealed induction of genes possibly involved in the switch to the survival stage. The interactions were different depending on the presence or absence of the virus. P. betae alone alleviates plant defense response, playing hide-and-seek with sugar beet and allowing for their mutual development. Conversely, BNYVV manipulates plant defense and promotes the rapid invasion of plant roots by P. betae. This accelerated colonization is accompanied by the development of thick-walled resting spores, supporting the virus survival. [Formula: see text] Copyright © 2022 The Author(s). This is an open access article distributed under the CC BY-NC-ND 4.0 International license .