bluuebunny/crossref_metadata_2025_split huggingface dataset:
Investigation of the added value of CT-based radiomics in predicting the development of brain metastases in patients with radically treated stage III NSCLC
Authors: Keek Simon A. , Kayan Esma , Chatterjee Avishek , Belderbos José S. A. , Bootsma Gerben , van den Borne Ben , Dingemans Anne-Marie C. , Gietema Hester A. , Groen Harry J. M. , Herder Judith , Pitz Cordula , Praag John , De Ruysscher Dirk , Schoenmaekers Janna , Smit Hans J. M. , Stigt Jos , Westenend Marcel , Zeng Haiyan , Woodruff Henry C. , Lambin Philippe , Hendriks Lizza 
Published: August 2022

Introduction: Despite radical intent therapy for patients with stage III non-small-cell lung cancer (NSCLC), cumulative incidence of brain metastases (BM) reaches 30%. Current risk stratification methods fail to accurately identify these patients. As radiomics features have been shown to have predictive value, this study aims to develop a model combining clinical risk factors with radiomics features for BM development in patients with radically treated stage III NSCLC. Methods: Retrospective analysis of two prospective multicentre studies. Inclusion criteria: adequately staged [18F-fluorodeoxyglucose positron emission tomography-computed tomography (18-FDG-PET-CT), contrast-enhanced chest CT, contrast-enhanced brain magnetic resonance imaging/CT] and radically treated stage III NSCLC, exclusion criteria: second primary within 2 years of NSCLC diagnosis and prior prophylactic cranial irradiation. Primary endpoint was BM development any time during follow-up (FU). CT-based radiomics features ( N = 530) were extracted from the primary lung tumour on 18-FDG-PET-CT images, and a list of clinical features ( N = 8) was collected. Univariate feature selection based on the area under the curve (AUC) of the receiver operating characteristic was performed to identify relevant features. Generalized linear models were trained using the selected features, and multivariate predictive performance was assessed through the AUC. Results: In total, 219 patients were eligible for analysis. Median FU was 59.4 months for the training cohort and 67.3 months for the validation cohort; 21 (15%) and 17 (22%) patients developed BM in the training and validation cohort, respectively. Two relevant clinical features (age and adenocarcinoma histology) and four relevant radiomics features were identified as predictive. The clinical model yielded the highest AUC value of 0.71 (95% CI: 0.58–0.84), better than radiomics or a combination of clinical parameters and radiomics (both an AUC of 0.62, 95% CIs of 0.47–076 and 0.48–0.76, respectively). Conclusion: CT-based radiomics features of primary NSCLC in the current setup could not improve on a model based on clinical predictors (age and adenocarcinoma histology) of BM development in radically treated stage III NSCLC patients.
Front-line treatment for advanced non-small-cell lung cancer and ALK fusion: a network meta-analysis
Authors: Wen Yaokai , Jiang Tao , Wu Xiangrong , Peng Haoxin , Ren Shengxiang , Zhou Caicun 
Published: August 2022

Background: It remains unknown what is the optimal front-line choice for advanced non-small-cell lung cancer (NSCLC) with anaplastic lymphoma kinase (ALK) fusion. Methods: We conducted a systematic review and network meta-analysis of randomized phase III clinical trials comparing two or more treatments as the front-line setting for patients with advanced ALK-positive NSCLC. Results: Nine phase III randomized clinical trials with 2367 patients were included. As to efficacy, lorlatinib had the most favorable progression-free survival [PFS; surface under the cumulative ranking curve (SUCRA) = 98.4%] in the first-line setting, with noticeable outcome benefits versus chemotherapy [hazard ratio (HR): 0.12; 95% confidence interval (CI): 0.08–0.19], crizotinib (HR: 0.28; 95% CI: 0.19–0.41), ceritinib (HR: 0.22; 95% CI: 0.13–0.37), and brigatinib (HR: 0.58; 95% CI: 0.35–0.96), as well as beneficial trends when compared with alectinib (HR: 0.66; 95% CI: 0.41–1.04) and ensartinib (HR: 0.62; 95% CI: 0.36–1.08). Meanwhile, alectinib showed the optimal overall survival (OS; SUCRA = 91.2%), with significant improvements over chemotherapy (HR: 0.47; 95% CI: 0.30–0.72) and crizotinib (HR: 0.58; 95% CI: 0.41–0.82). Similarly, brigatinib also displayed prolonged OS compared with crizotinib after adjustment for crossover by the marginal structural model (HR: 0.54; 95% CI: 0.31–0.92). In terms of safety, alectinib had the fewest grade 3–5 adverse events (SUCRA = 98.9%), with marked advantages versus crizotinib [odds ratio (OR): 0.67; 95% CI: 0.46–0.97], ceritinib (OR: 0.21; 95% CI: 0.10–0.43), brigatinib (OR: 0.37; 95% CI: 0.20–0.69), ensartinib (OR: 0.48; 95% CI: 0.27–0.89), and lorlatinib (OR: 0.30; 95% CI: 0.16–0.54). Conclusions: Lorlatinib may have advantageous PFS compared with other agents but a greater risk of severe toxicity. Second-generation inhibitors, including alectinib, brigatinib, and ensartinib, provide major efficacy with less toxicity and remain appropriate regimens in the front-line setting.
Relationship between onset of psoriasis and spondyloarthritis symptoms with clinical phenotype and diagnosis: data from REGISPONSER registry
Authors: Gómez-Garcia Ignacio , García-Puga Teresa , Font-Ugalde Pilar , Puche-Larrubia Maria Angeles , Barbarroja Nuria , Ruiz-Limón Patricia , Escudero-Contreras Alejandro , Collantes-Estévez Eduardo , López-Medina Clementina 
Published: August 2022

Background: The relationship of psoriasis and spondyloarthritis (SpA) is well-known, and the age of appearance of different manifestations has been described as a determinant of SpA phenotype. However, differences between Spa with psoriasis and psoriatic arthritis (PsA) are still controversial. Objectives: To evaluate whether the time of onset of psoriasis relative to the appearance of rheumatic symptoms in patients with SpA is associated with a clinical phenotype, a rheumatologist’s diagnosis and the evolution of the disease. Design: This was a cross-sectional study with data extracted from the REGISPONSER (Spondyloarthritis Registry of the Spanish Rheumatology Society) registry. Methods: All patients had data available for both psoriasis and SpA dates of onset. Patients were classified into two groups depending on the time of appearance of psoriasis: psoriasis before or after rheumatic symptoms. The clinical characteristics, disease activity, radiographic damage, functional ability and received treatments were compared between the two groups. Moreover, the rheumatologists’ diagnoses were compared between the two groups. Univariate and multivariate logistic regressions were conducted to evaluate the factors associated with each group. Results: A total of 433/2367 (18.3%) patients included in the REGISPONSER database had psoriasis: 330 (76.2%) patients had psoriasis before rheumatic symptoms, and 103 (23.8%) had psoriasis after rheumatic symptoms. Patients with psoriasis before rheumatic symptoms had a shorter disease duration and a lower body mass index, a lower prevalence of both HLA-B27 antigens and anterior uveitis, a higher prevalence of dactylitis and an increase in levels of the erythrocyte sedimentation rate (ESR). Furthermore, a higher prevalence of PsA diagnoses (78.1% versus 56.4%) and a more frequent fulfilment of the CASPAR criteria (57.5% versus 42.2%) were found in these patients. The use of DMARDs was not significantly different between the two groups. Conclusion: The time of appearance of psoriasis is associated with the clinical phenotype of SpA and could determine a diagnosis of PsA by rheumatologists.
Functional Outcomes and Complications Associated With Total Talus Arthroplasty: A Systematic Review
Authors: Bischoff Alex , Stone Ryan , Dao Tung , Anderson Steven , Hill Zachary , Steginsky Brian , Mendicino Robert 
Published: August 2022

Total talus arthroplasty (TTA) is a motion sparing procedure which can be utilized in specific and unique cases of talar necrosis and/or collapse. Literature on TTA is limited and predominantly composed of case studies or case reports. The purpose of this publication is to compile a systematic review of functional outcomes and complications associated with TTA. A search of current literature on TTA with >1-year follow-up was performed. Studies that described talar body implants or talonavicular implants were excluded. Twenty articles met inclusion criteria, which represented 161 TTAs. The average follow-up was 37.35 months (9-60 months). The indication for a TTA was predominately avascular necrosis of the talus, comprising 75.78% (122/161) of cases. The overall complication rate was 9.32% (15/161), with wound healing complications (5/161), replacement or implantation of a tibial component (4/161), and medial malleolus fracture (3/161) being the most common. One patient required proximal amputation due to residual pain and deformity. Functionally, American Orthopedic Foot and Ankle Score increased from 27.93 preoperative to 81.99 postoperative and Japanese Society for Surgery of the Foot Score increased from 43.2 preoperative to 89.34 postoperative. Visual analog scale pain score decreased from 6.44 to 2.60. Total ankle range of motion increased from 36.60° to 46.74°. Ankle plantarflexion increased by 3.45° and ankle dorsiflexion increased by 6.69°. Overall, available literature on TTA appears to be in favor of the procedure when indicated. Levels of Evidence: 4
Association of Barrett’s esophagus with Helicobacter pylori infection: a meta-analysis
Authors: Ma Shaoze , Guo Xiaozhong , Wang Chunmei , Yin Yue , Xu Guangqin , Chen Hongxin , Qi Xingshun 
Published: August 2022

Background and Aims: Barrett’s esophagus (BE) is the only recognized precursor for esophageal adenocarcinoma. Helicobacter pylori ( H. pylori) infection is a major contributing factor towards upper gastrointestinal diseases, but its relationship with BE remains controversial. Some previous studies suggested that H. pylori infection negatively correlated with BE, while others did not. This may be attributed to the difference in the selection of control groups among studies. The present meta-analysis aims to clarify their association by combining all available data from well-designed studies. Methods: The PubMed, EMBASE, and Cochrane Library databases were searched. Odds ratios (ORs) with 95% confidence intervals (CIs) were pooled by a random-effects model. Heterogeneity was evaluated using the Cochran’s Q test and I2 statistics. Meta-regression, subgroup, and leave-one-out sensitivity analyses were employed to explore the sources of heterogeneity. Results: Twenty-four studies with 1,354,369 participants were included. Meta-analysis found that patients with BE had a significantly lower prevalence of H. pylori infection than those without (OR = 0.53, 95% CI = 0.45–0.64; p < 0.001). The heterogeneity was statistically significant ( I² = 79%; p < 0.001). Meta-regression, subgroup, and leave-one-out sensitivity analyses did not find any source of heterogeneity. Meta-analysis of 7 studies demonstrated that CagA-positive H. pylori infection inversely correlated with BE (OR = 0.25, 95% CI = 0.15–0.44; p = 0.000), but not CagA-negative H. pylori infection (OR = 1.22, 95% CI = 0.90–1.67; p = 0.206). Meta-analysis of 4 studies also demonstrated that H. pylori infection inversely correlated with LSBE (OR = 0.39, 95% CI = 0.18–0.86; p = 0.019), but not SSBE (OR = 0.73, 95% CI = 0.30–1.77; p = 0.484). Conclusion: H. pylori infection negatively correlates with BE. More experimental studies should be necessary to elucidate the potential mechanisms in future.
Can You Feel it? – Correlation Between Intraoperatively Perceived Bone Quality and Objectively Measured Bone Mineral Density
Authors: Oberthür Swantje , Roch Paul Jonathan , Klockner Friederike , Jäckle Katharina Blanka , Viezens Lennart , Lehmann Wolfgang , Sehmisch Stephan , Weiser Lukas 
Published: August 2022

Study Design clinical study. Objectives Loosening of pedicle screws is a frequent complication in patients with osteoporosis. The indication for additional stabilization, such as cement augmentation, is more often based on the subjective intraoperative feeling of the surgeon than on a preoperative bone mineral density (BMD) measurement. Aim was to evaluate the correlation of the intraoperative perceived bone quality in comparison to the objectively measured BMD. Methods A total of 62 patients undergoing dorsal stabilization using pedicle screws at a level-1 trauma center were analyzed. The preoperative CT scan measured each instrumented vertebra's pedicle size and BMD. During the surgery, the perceived screw stability was graded by the respective surgeon for each screw. Results 204 vertebral bodies were evaluated. Looking at all implanted screws a significant correlation between the measured BMD and the perceived screw stability was found (Resident r = .450; R2 = .202; P < .001/Attending r = .364; R2 = .133; P < .001), but there was no significant correlation in the osteoporotic patients (Resident P = .148 / Attending P = .907). The evaluation of the screws implanted in osteoporotic vertebrae showed that the surgeons considered a total of 31% of these screws to be sufficiently stable. Conclusions There was no significant correlation between the measured BMD and the perceived pedicle screw stability in the group with osteopenic / osteoporotic bone (<100 mg/cm³). The results indicate that it is not possible to reliably determine the bone quality and the resulting screw stability in patients with reduced BMD. The preoperative measurement of the BMD should become a crucial part of preoperative planning.
Comparison of Rotatory and Sagittal Laxity After Single-Bundle Versus Double-Bundle ACL Reconstruction: Outcomes at 7-Year Follow-up
Authors: Severyns Mathieu , Mallet Julien , Plawecki Stéphane 
Published: August 2022

Background: Biomechanical studies have shown excellent anteroposterior and rotatory laxity control after double-bundle (DB) anterior cruciate ligament (ACL) reconstruction, but no clinical studies have compared midterm (>5-year) residual laxity between the DB and single-bundle (SB) techniques. Purpose: To clinically compare sagittal and rotatory laxities and residual sagittal laxity on the KT-1000 arthrometer between patients treated with an SB ACL reconstruction and those treated with a DB ACL reconstruction at the 7-year follow-up. Study Design: Cohort study; Level of evidence, 3. Methods: A total of 110 patients were included between January 2006 and December 2007. The patients were randomly assigned into 2 groups: those treated with SB ACL reconstruction (n = 63) and those treated with the DB technique (n = 47). All patients were then reviewed at a minimum of 7 years of follow-up; patients with ACL rerupture (n = 3 in the SB group and n = 2 in the DB group) were excluded from the postoperative comparative analysis. Residual anterior laxity (Lachman test), rotatory laxity (pivot-shift test), and sagittal laxity (KT-1000 arthrometer side-to-side difference) were measured and compared between the 2 groups. Results: The mean age at surgery was 23.0 ± 5.1 years for the DB group and 28.1 ± 7.0 years for the SB group, and the mean follow-up was 7.4 ± 0.8 years. No statistically significant differences were found between the 2 groups in terms of age, sex, preoperative laxity on KT-1000, preoperative Tegner score, or concomitant meniscal lesions. Residual postoperative laxity via Lachman testing ( P < .01), pivot-shift testing ( P = .042), and the KT-1000 arthrometer ( P < .01) was statistically significantly in favor of DB reconstruction. Conclusion: DB ACL reconstruction allowed better control of anterior stability during the evaluation via the Lachman test and via objective measurement on the KT-1000, as well as rotatory stability at a minimum of 7 years of follow-up.
Failure Rates of Suture Anchor Fixation Versus Transosseous Tunnel Technique for Patellar Tendon Repair: A Systematic Review and Meta-analysis of Biomechanical Studies
Authors: Imbergamo Casey , Sequeira Sean , Bano Joseph , Rate William R. , Gould Heath 
Published: August 2022

Background: Transosseous tunnel (TO) repair is considered the gold standard for patellar tendon rupture; however, suture anchor (SA) repair has emerged as a viable alternative in recent years. Although both these techniques are used widely in clinical practice, the most biomechanically optimal construct for patellar tendon repair remains unknown. Purpose: To examine published studies on the biomechanical properties of TO and SA fixation for patellar tendon repair in terms of ultimate load to failure and cyclic gap formation. The null hypothesis was that there would be no significant difference in either outcome measure between the groups. Study Design: Systematic review. Methods: A systematic review using PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines was performed by searching PubMed, the Cochrane Library, and Embase to identify studies that analyzed the biomechanical properties of SA and TO techniques for repair of a ruptured patellar tendon. The search phrase implemented was “patellar tendon repair.” Meta-analysis was performed to provide a quantitative comparison of the 2 techniques with regard to ultimate load to failure and cyclic gap displacement. Weighted averages were calculated for all quantitative outcomes, and outcomes were summarized in a forest plot. A random-effects model was used to account for the heterogeneity among the included studies in the final statistical analysis. Results: Of 875 studies initially screened, the inclusion criteria were met by 7 studies, including 128 cadaveric specimens (66 SA, 62 TO). The pooled analysis from 6 studies reporting on gap displacement revealed a statistically significant difference in favor of SA versus TO fixation ( P < .001). Pooled analysis from 7 studies reporting on ultimate load to failure did not reveal a statistically significant difference between the use of SA and TO for tendon repair ( P = .465). Conclusion: Our systematic review revealed that the use of SA fixation for patellar tendon repair was associated with lower cyclic gap displacement when compared with TO fixation. There was no significant difference in ultimate load to failure between the repair techniques.
Perception of Oral Health–Related Quality of Life in Children with Epidermolysis Bullosa: A Quantitative and Qualitative Study
Authors: Marty M. , Chiaverini C. , Milon C. , Costa-Mendes L. , Kémoun P. , Mazereeuw-Hautier J. , Joseph C. 
Published: August 2022

Epidermolysis bullosa (EB) is a group of rare skin diseases that can strongly affect the oral mucosa. The aim of the study was to describe the perception of oral health– related quality of life (OHRQoL) in children living with EB. A quantitative and qualitive study was conducted. First, a quantitative analysis was used to compare the Child Oral Health Impact Profile (COHIP) scores of 23 patients living with EB to normative values. Second, a qualitative approach was taken to help understand the oral health experience of 10 children (aged 5–17 y) living with EB until thematic saturation was reached. For every COHIP domain, the scores were significantly lower in patients living with EB than in healthy patients (P = 0.001). The thematic analysis provided several themes: young patients suffer from EB oral complications, with which they deal in different ways; they experience functional disorders, mainly in eating and speaking; and they also require esthetic dental care. The results of this mixed-method study show that, from the perspective of affected children, that EB affects OHRQoL. Using the children’s own words makes it possible to understand both the difficulties they face and their ability to adapt to these difficulties. Their words also show us what they want from the treatment and help us to identify means of improving practices. Knowledge Transfer Statement: The results of this study confirm the difficulties experienced by patients in the oral sphere. They also show that patients are able to adapt and that their demands go beyond functional rehabilitation. This work should encourage dental practitioners to be part of the overall management of the disease, involving regular checkups, preventive dental measures, and oral hygiene education. Therefore, more effective communication is required, not only between the dental and dermatological teams but also with the parents and caregivers.
Practice Patterns and Career Satisfaction in Recent Head and Neck Oncology Fellowship Graduates
Authors: Hong Scott A. , Bergman Jonathan A. , Walker Ronald J. , Massa Sean T. 
Published: August 2022

ObjectiveExamine the characteristics of recent head and neck (H&N) oncology fellowship graduates and assess their current perceptions of career alignment and satisfaction.MethodsH&N fellowship graduates from American Head and Neck Society–accredited programs between 2015 to 2020 were surveyed. Two‐sample t tests and analysis of variance tests were used to determine the effect of respondents’ demographics, fellowship characteristics, career preferences, and current practice on their degree of career alignment with expectations and overall job satisfaction.ResultsFifty‐eight fellowship graduates completed the cross‐sectional survey. Of all respondents, 52 (89.7%) primarily preferred an academic job, of whom 5 (9.6%) went into private practice. Respondents in private practice, those treating general otolaryngology patients, and those who do not work with residents demonstrated significantly poorer job alignment and career satisfaction as compared with those in academic medicine, those treating only H&N patients, and those working with residents, respectively.DiscussionThe majority of graduating H&N fellows prefer a job in academic medicine; however, there may be an insufficient number of desirable academic positions available each year to meet such demand.Implications for PracticeBy setting realistic career expectations, preparing for a mixed scope of practice, and integrating resident involvement into private practice groups, H&N providers may ultimately find more fulfillment in their work. These findings could also be valuable to the American Head and Neck Society and fellowship programs in designing training and in planning for the number of available fellowship positions each year.