bluuebunny/crossref_metadata_2025_split huggingface dataset:
Stelco, Sears Canada and CN Rail: archival sources of advertising and marketing history in the Library and Archives Canada collection
Authors: Campbell Dalton , Griffin Kelly Anne , Elliott Andrew 
Published: April 2022

Purpose
The archival records of Canadian corporations held by Library and Archives Canada (LAC) are a rich source of primary documents for the study of the history of marketing and advertising in Canada. The paper discusses the records of iconic department store Sears Canada, steel manufacturer Stelco, and Canadian National, the country’s largest railway, provide primary source material on marketing, sales, catalogues, promotions, celebrity endorsements, sponsorship of charitable causes and other areas of publicity. Additionally, discussing archival records provides a case study of the major archival processes involved in making historical documents available to researchers and the general public, including appraisal and evaluation, archival processing, preservation and digitisation.

Design/methodology/approach
The paper discusses and highlights primary source archival records for the study of marketing history. These archival fonds are unique primary source records that document three historically significant Canadian corporations and their roles in Canadian history.

Findings
The archival records of Canadian corporations held by Library and Archives Canada (LAC) are a rich source of primary documents for the study of the history of marketing and advertising in Canada. The records of iconic department store Sears Canada, steel manufacturer Stelco, and Canadian National, the country’s largest railway, provide primary source material on marketing, sales, catalogues, promotions, celebrity endorsements, sponsorship of charitable causes and other areas of publicity. Additionally, discussing archival records provides a case study of the major archival processes involved in making historical documents available to researchers and the general public, including appraisal and evaluation, archival processing, preservation and digitisation.

Originality/value
The archival records of Canadian corporations held by Library and Archives Canada (LAC) are a rich source of primary documents for the study of the history of marketing and advertising in Canada. The records of iconic department store Sears Canada, steel manufacturer Stelco, and Canadian National, the country’s largest railway, provide primary source material on marketing, sales, catalogues, promotions, celebrity endorsements, sponsorship of charitable causes and other areas of publicity. Additionally, discussing archival records provides a case study of the major archival processes involved in making historical documents available to researchers and the general public, including appraisal and evaluation, archival processing, preservation and digitisation.
Relative deprivation, perceived status conflict and innovative behavior of outsourced employees: multiple moderating effects of dual organizational support
Authors: Wang Pengcheng , Qin Chuanyan , Liu Shanshi 
Published: April 2022

PurposeHow to manage outsourced employees in interorganizational teams with triangular relationships has not yet attracted enough attention. Based on relative deprivation theory, this study explores how relative deprivation affects outsourced employees’ innovative behavior and investigates the complex moderating effects of dual organizational support.Design/methodology/approachThe authors tested their hypothesis by conducting a two-wave survey; responses to a questionnaire were collected from 283 outsourced employees and their managers among 52 client organizations.FindingsResults found that relative deprivation negatively influences the outsourced employees’ innovative behavior by eliciting their perceptions of status conflict. Support from client (supplier) organization attenuates (aggravates) the positive impact of relative deprivation on innovative behavior throughout status conflict. The moderating effect of client organizational support was moderated by support from supplier organization.Research limitations/implicationsThe authors selected the outsourced employees in a Chinese context to conduct this study, and the results need to be generalized in future research.Practical implicationsClient organizational support can alleviate the negative effect of relative deprivation on outsourced employees, whereas supplier organization support aggravates the negative effect; managers should pay attention to the different effects of the two organizations’ support and provide reasonable support for outsourced employees.Originality/valueThis study identified the mechanism of relative deprivation’s effect on outsourced employees’ innovative behavior from the perspective of interpersonal interaction and compared the effect of support from dual organizations. This study expands the research on triangular relationships, relative deprivation, status conflict and other field.
Virus isolation data improve host predictions for New World rodent orthohantaviruses
Authors: Mull Nathaniel , Carlson Colin J. , Forbes Kristian M. , Becker Daniel J. 
Published: April 2022

Abstract

Identifying reservoir host species is crucial for understanding the ecology of multi‐host pathogens and predicting risks of pathogen spillover from wildlife to people.

Predictive models are increasingly used for identifying ecological traits and prioritizing surveillance of likely zoonotic reservoirs, but these often employ different types of evidence for establishing host associations. Comparisons between models with different infection evidence are necessary to guide inferences about the trait profiles of likely hosts and identify which hosts and geographical regions are likely sources of spillover.

Here, we use New World rodent–orthohantavirus associations to explore differences in the performance and predictions of models trained on two types of evidence for infection and onward transmission: RT‐PCR and live virus isolation data, representing active infections versus host competence, respectively. Orthohantaviruses are primarily carried by muroid rodents and cause the diseases haemorrhagic fever with renal syndrome (HFRS) and hantavirus cardiopulmonary syndrome (HCPS) in humans.

We show that although boosted regression tree (BRT) models trained on RT‐PCR and live virus isolation data both performed well and capture generally similar trait profiles, rodent phylogeny influenced previously collected RT‐PCR data, and BRTs using virus isolation data displayed a narrower list of predicted reservoirs than those using RT‐PCR data. BRT models trained on RT‐PCR data identified 138 undiscovered hosts and virus isolation models identified 92 undiscovered hosts, with 27 undiscovered hosts identified by both models. Distributions of predicted hosts were concentrated in several different regions for each model, with large discrepancies between evidence types. As a form of validation, virus isolation models independently predicted several orthohantavirus–rodent host associations that had been previously identified through empirical research using RT‐PCR.

Our model predictions provide a priority list of species and locations for future orthohantavirus sampling. More broadly, these results demonstrate the value of multiple data types for predicting zoonotic pathogen hosts. These methods can be applied across a range of systems to improve our understanding of pathogen maintenance and increase efficiency of pathogen surveillance.
pamlr: A toolbox for analysing animal behaviour using pressure, acceleration, temperature, magnetic or light data in R
Authors: Dhanjal‐Adams Kiran L. , Willener Astrid S. T. , Liechti Felix 
Published: April 2022

AbstractLight‐level geolocators have revolutionised the study of animal behaviour. However, lacking spatial precision, their usage has been primary targeted towards the analysis of large‐scale movements. Recent technological developments have allowed the integration of magnetometers and accelerometers into geolocator tags in addition to barometers and thermometers, offering new behavioural insights.Here, we introduce an R toolbox for identifying behavioural patterns from multisensor geolocator tags, with functions specifically designed for data visualisation, calibration, classification and error estimation. More specifically, the package allows for the flexible analysis of any combination of sensor data using k‐means clustering, expectation maximisation binary clustering, hidden Markov models and changepoint analyses. Furthermore, the package integrates tailored algorithms for identifying periods of prolonged high activity (most commonly used for identifying migratory flapping flight), and pressure changes (most commonly used for identifying dive or flight events).Finally, we highlight some of the limitations, implications and opportunities of using these methods.
Targeted clearance of p21‐ but not p16‐positive senescent cells prevents radiation‐induced osteoporosis and increased marrow adiposity
Authors: Chandra Abhishek , Lagnado Anthony B. , Farr Joshua N. , Doolittle Madison , Tchkonia Tamara , Kirkland James L. , LeBrasseur Nathan K. , Robbins Paul D. , Niedernhofer Laura J. , Ikeno Yuji , Passos João F. , Monroe David G. , Pignolo Robert J. , Khosla Sundeep 
Published: April 2022

AbstractCellular senescence, which is a major cause of tissue dysfunction with aging and multiple other conditions, is known to be triggered by p16Ink4a or p21Cip1, but the relative contributions of each pathway toward inducing senescence are unclear. Here, we directly addressed this issue by first developing and validating a p21‐ATTAC mouse with the p21Cip1 promoter driving a “suicide” transgene encoding an inducible caspase‐8 which, upon induction, selectively kills p21Cip1‐expressing senescent cells. Next, we used the p21‐ATTAC mouse and the established p16‐INK‐ATTAC mouse to directly compare the contributions of p21Cip1 versus p16Ink4a in driving cellular senescence in a condition where a tissue phenotype (bone loss and increased marrow adiposity) is clearly driven by cellular senescence—specifically, radiation‐induced osteoporosis. Using RNA in situ hybridization, we confirmed the reduction in radiation‐induced p21Cip1‐ or p16Ink4a‐driven transcripts following senescent cell clearance in both models. However, only clearance of p21Cip1+, but not p16Ink4a+, senescent cells prevented both radiation‐induced osteoporosis and increased marrow adiposity. Reduction in senescent cells with dysfunctional telomeres following clearance of p21Cip1+, but not p16Ink4a+, senescent cells also reduced several of the radiation‐induced pro‐inflammatory senescence‐associated secretory phenotype factors. Thus, by directly comparing senescent cell clearance using two parallel genetic models, we demonstrate that radiation‐induced osteoporosis is driven predominantly by p21Cip1‐ rather than p16Ink4a‐mediated cellular senescence. Further, this approach can be used to dissect the contributions of these pathways in other senescence‐associated conditions, including aging across tissues.
Neo‐adjuvant FOLFIRINOX in borderline resectable and locally advanced pancreatic adenocarcinoma
Authors: Temraz Sally , Nassar Farah , Hammoud Miza Salim , Mukherji Deborah , O'Reilly Eileen M. , Dbouk Haifa , Farhat Fadi , Charafeddine Maya , Faraj Walid , Khalifeh Mohammad J. , Abou‐Alfa Ghassan K. , Shamseddine Ali 
Published: April 2022

AbstractBackgroundSurgery and systemic therapy provide the best option for long‐term cancer control in localized resectable pancreas cancer. The present study assessed the efficacy and safety of neoadjuvant treatment with FOLFIRINOX in patients with borderline resectable (BR) and locally advanced (LA) pancreas cancer (PDAC).MethodsThis was a prospective noninterventional observational trial of neoadjuvant FOLFIRINOX in BR and LA PDAC. The primary objective was the R0/R1 surgical resection rate. Secondary objectives included progression free survival (PFS) and overall survival (OS), tolerability, and toxicity.ResultsForty‐nine patients were enrolled between 2013 and 2019; the majority had LA disease (59.2%). Median age was 61 years, and median Ca 19‐9 level pretreatment was 523.4 μmol/L. Following neoadjuvant FOLFIRINOX, 11 patients (22.5%) underwent surgical resection, the majority of which were BR at diagnosis (72.7%). Median OS and PFS for the entire group were 25 (95% CI: 17.2–32.8) and 12 months (95% CI: 9.7–13.3), respectively. Median PFS in BR patients was 14 (95% CI: 10.5–17.5) compared to 12 months (95% CI: 5.2–18.8) in patients with LA patients. Median OS and PFS were not reached in patients who underwent surgical resection as compared to 22 (95% CI: 18.6–25.4) and 9 months (95% CI: 4.2–13.9) in those who did not, respectively. Grade 3/4 neutropenia, leukopenia, neuropathy, nausea/vomiting, and diarrhea occurred in 6.3%, 2.1%, 10.4%, 4.2%, and 8.3%, respectively.ConclusionNeoadjuvant FOLFIRINOX is an active regimen for patients with LA/BR PDAC with a resection rate of 22.5%. These results are in line with prior data.
The Spatial Politics of Infrastructure‐Led Development: Notes from an Asian Postcolony
Authors: Akhter Majed , Akhtar Aasim Sajjad , Karrar Hasan H. 
Published: April 2022

AbstractThis essay introduces the Symposium on the spatial politics of infrastructure‐led development in Pakistan. It situates the Symposium (and the research site of Pakistan) with respect to the geographical literature on infrastructural politics more broadly, and the Belt and Road Initiative specifically. The essay also previews the seven contributing articles of the Symposium through a discussion of three cross‐cutting themes: securing the periphery, technologies of urban governance, and contested environments. The essay concludes by calling for the interrogation of infrastructural politics in specific regions as sites within a larger global conjunctural analytical framework.
Using robots at work during the COVID‐19 crisis evokes passion decay: Evidence from field and experimental studies
Authors: Tang Pok Man , Koopman Joel , Elfenbein Hillary Anger , Zhang Jack H. , De Cremer David , Li Chi Hon , Chan Elsa T. 
Published: April 2022

AbstractThe growing trend of introducing robots into employees' work lives has become increasingly salient during the global COVID‐19 pandemic. In light of this pandemic, it is likely that organisational decision‐makers are seeing value in coupling employees with robots for both efficiency‐ and health‐related reasons. An unintended consequence of this coupling, however, may be an increased level of work routinisation and standardisation. We draw primarily from the model of passion decay from the relationship and clinical psychology literature to develop theory and test a model arguing that passion decays as employees increasingly interact with robots for their work activities. We demonstrate that this passion decay leads to an increase of withdrawal behaviour from both the domains of work and family. Drawing further from the model of passion decay, we reveal that employees higher in openness to experience are less likely to suffer from passion decay upon more frequent interactions with robots in the course of work. Across a multi‐source, multi‐wave field study conducted in Hong Kong (Study 1) and a simulation‐based experiment conducted in the United States (Study 2), our hypotheses received support. Theoretical and practical implications are discussed.
Letter: sPD‐1 as a predictor for HBsAg seroconversion—shed light on inactive carriers with chronic hepatsitis B
Authors: Vyas Ashish K. , Jindal Ankur 
Published: April 2022

LINKED CONTENTThis article is linked to Hu et al papers. To view these articles, visit https://doi.org/10.1111/apt.16752 and https://doi.org/10.1111/apt.16863
Letter: serum growth differentiation factor 15 predicts hepatocellular carcinoma occurrence after hepatitis C virus elimination
Authors: Chen Lin , Tao Xuemei , Zhao Youfei , Zeng Minghui , Mi Yuqiang , Xu Liang 
Published: April 2022

LINKED CONTENTThis article is linked to Myojin.et al's paper. To view this article, visit https://doi.org/10.1111/apt.16691 and https://doi.org/10.1111/apt.16862.
Letter: inflammatory bowel disease services during the Covid‐19 pandemic
Authors: Mungmunpuntipantip Rujittika , Wiwanitkit Viroj 
Published: April 2022

LINKED CONTENTThis article is linked to Deputy et al papers. To view these articles, visit https://doi.org/10.1111/apt.16800 and https://doi.org/10.1111/apt.16884
Editorial: is it not just PROs, but the most important individual PRO, that really matters in Crohn’s disease?
Authors: Cameron Karla , Sparrow Miles P. 
Published: April 2022

LINKED CONTENTThis article is linked to Wong et al papers. To view these articles, visit https://doi.org/10.1111/apt.16805 and https://doi.org/10.1111/apt.16866
Letter: skipping breakfast is associated with an increased long‐term cardiovascular mortality in metabolic dysfunction‐associated fatty liver disease (MAFLD) but not MAFLD‐free individuals
Authors: Wu Yao‐Cheng , Wei James Cheng‐Chung , Yeh Chih‐Jung 
Published: April 2022

LINKED CONTENTThis article is linked to Xie et al papers. To view these articles, visit https://doi.org/10.1111/apt.16727 and https://doi.org/10.1111/apt.16876
Letter: sPD‐1 as a predictor for HBsAg seroclearance—shed light on inactive carriers with chronic hepatitis B. Authors' reply
Authors: Jeng Wen‐Juei , Pan Mei‐Hung , Yang Hwai‐I 
Published: April 2022

LINKED CONTENTThis article is linked to Hu et al papers. To view these articles, visit https://doi.org/10.1111/apt.16752 and https://doi.org/10.1111/apt.16833
Editorial: is it not just PROs, but the most important individual PRO, that really matters in Crohn’s disease? Authors’ reply
Authors: Wong Emily C. L. , Dulai Parambir S. , Marshall John K. , Jairath Vipul , Reinisch Walter , Narula Neeraj 
Published: April 2022

LINKED CONTENTThis article is linked to Wong et al papers. To view these articles, visit https://doi.org/10.1111/apt.16805 and https://doi.org/10.1111/apt.16843
Letter: skipping breakfast is associated with an increased long‐term cardiovascular mortality in metabolic dysfunction‐associated fatty liver disease (MAFLD) but not in MAFLD‐free individuals. Authors' reply
Authors: Xie Jiarong , Xu Lei , Xu Chengfu 
Published: April 2022

LINKED CONTENTThis article is linked to Xie et al papers. To view these articles, visit https://doi.org/10.1111/apt.16727 and https://doi.org/10.1111/apt.16849
Editorial: reply to delayed gastric emptying as an independent predictor of mortality in gastroparesis—it is clinically relevant after all! Authors' reply
Authors: Gourcerol Guillaume , Tavolacci Marie Pierre 
Published: April 2022

LINKED CONTENTThis article is linked to Gourcerol et al papers. To view these articles, visit https://doi.org/10.1111/apt.16827 and https://doi.org/10.1111/apt.16857
Editorial: does TAF have a better or worse safety profile than TDF, to treat hepatitis B? Authors' reply
Authors: Lim Young‐Suk , Lampertico Pietro 
Published: April 2022

LINKED CONTENTThis article is linked to Lim et al papers. To view these articles, visit https://doi.org/10.1111/apt.16788 and https://doi.org/10.1111/apt.16854
Editorial: is there a role for monitoring intermediate anti‐TNF drug concentrations in IBD? Authors’ reply
Authors: Roblin Xavier , Paul Stephane 
Published: April 2022

LINKED CONTENTThis article is linked to Roblin et al papers. To view these articles, visit https://doi.org/10.1111/apt.16852 and https://doi.org/10.1111/apt.16889
Glutamate blunts cell‐killing effects of neutrophils in tumor microenvironment
Authors: Xiong Tiantian , He Ping , Zhou Mi , Zhong Dan , Yang Teng , He Wenhui , Xu Zhizhen , Chen Zongtao , Liu Yang‐Wuyue , Dai Shuang‐Shuang 
Published: April 2022

AbstractNeutrophils are the first defenders of the innate system for injury and infection. They have gradually been recognized as important participants in tumor initiation and development due to their heterogeneity and plasticity. In the tumor microenvironment (TME), neutrophils can exert antitumor and protumor functions, depending on the surroundings. Tumor cells systemically alter intracellular amino acid (AA) metabolism and extracellular AA distribution to meet their proliferation need, leading to metabolic reprogramming and TME reshaping. However, the underlying mechanisms that determine how altered AAs affect neutrophils in TME are less‐explored. Here, we identified that abundant glutamate releasing from tumor cells blunted neutrophils’ cell‐killing effects toward tumor cells in vitro and in vivo. Mass spectrometric detection, flow cytometry, and western blot experiments proved that increased levels of pSTAT3/RAB10/ARF4, mediated by glutamate, were accompanied with immunosuppressive phenotypes of neutrophils in TME. We also discovered that riluzole, an FDA‐approved glutamate release inhibitor, significantly inhibited tumor growth by restoring neutrophils’ cell‐killing effects and decreasing glutamate secretion from tumor cells. These findings highlight the importance of tumor‐released glutamate on neutrophil transformation in TME, providing new possible cancer treatments targeting altered glutamate metabolism.
Disruptions, adjustments and hopes: The impact of the COVID‐19 pandemic on child well‐being in five Majority World Countries
Authors: Haffejee Sadiyya , Vostanis Panos , O'Reilly Michelle , Law Effie , Eruyar Seyda , Fleury Julianna , Hassan Sajida , Getanda Elijah 
Published: April 2022

AbstractDrawing on integrated data from focus groups and diary entries, we explored the impact of the COVID‐19 pandemic on child well‐being for children from five Majority World Countries. We focus on the disruptions the pandemic caused, the adjustments made in response to these, and children's vision of a post‐pandemic world. Underlying children's experiences of loss, boredom and concerns about educational progress, was an awareness of systemic inequalities that disadvantaged them or others in their community. Findings have implications on capturing children's voices through introspective and dialogical approaches that transcend cultures and for the development of preventive and responsive interventions during crises.
Transcriptional states and chromatin accessibility during bovine myoblasts proliferation and myogenic differentiation
Authors: Li Qian , Wang Yahui , Hu Xin , Zhang Yapeng , Li Hongwei , Zhang Qi , Cai Wentao , Wang Zezhao , Zhu Bo , Xu Lingyang , Gao Xue , Chen Yan , Gao Huijiang , Li Junya , Zhang Lupei 
Published: April 2022

AbstractObjectivesAlthough major advances have been made in bovine epigenome study, the epigenetic basis for fetal skeletal muscle development still remains poorly understood. The aim is to recapitulated the time course of fetal skeletal muscle development in vitro, and explore the dynamic changes of chromatin accessibility and gene expression during bovine myoblasts proliferation and differentiation.MethodsPDGFR‐ cells were isolated from bovine fetal skeletal muscle, then cultured and induced myogenic differentiation in vitro in a time‐course study (P, D0, D2,and D4). The assay for transposase‐accessible chromatin sequencing (ATAC‐seq) and RNA sequencing (RNA‐seq) were performed.ResultsAmong the enriched transcriptional factors with high variability, we determined the effects of MAFF, ZNF384, and KLF6 in myogenesis using RNA interference (RNAi). In addition, we identified both stage‐specific genes and chromatin accessibility regions to reveal the sequential order of gene expression, transcriptional regulatory, and signal pathways involved in bovine skeletal muscle development. Further investigation integrating chromatin accessibility and transcriptome data was conducted to explore cis‐regulatory regions in line with gene expression. Moreover, we combined bovine GWAS results of growth traits with regulatory regions defined by chromatin accessibility, providing a suggestive means for a more precise annotation of genetic variants of bovine growth traits.ConclusionOverall, these findings provide valuable information for understanding the stepwise regulatory mechanisms in skeletal muscle development and conducting beef cattle genetic improvement programs.