bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mental health stigma and discrimination in Ethiopia: evidence synthesis to inform stigma reduction interventions
Authors: Girma Eshetu , Ketema Bezawit , Mulatu Tesfahun , Kohrt Brandon A. , Wahid Syed Shabab , Heim Eva , Gronholm Petra C. , Hanlon Charlotte , Thornicroft Graham 
Published: June 2022

Abstract
Background
People with mental illnesses are at an increased risk of experiencing human rights violations, stigma and discrimination. Even though mental health stigma and discrimination are universal, there appears to be a higher burden in low- and middle-income countries. Anti-stigma interventions need to be grounded in local evidence. The aim of this paper was to synthesize evidence on mental health stigma and discrimination in Ethiopia to inform the development of anti-stigma interventions.

Methods
This evidence synthesis was conducted as a part of formative work for the International Study of Discrimination and Stigma Outcomes (INDIGO) Partnership research program. Electronic searches were conducted using PubMed for scientific articles, and Google Search and Google Scholar were used for grey literature. Records fulfilling eligibility criteria were selected for the evidence synthesis. The findings were synthesized using a framework designed to capture features of mental health stigma to inform cultural adaptation of anti-stigma interventions.

Results
A total of 37 records (2 grey literature and 35 scientific articles) were included in the evidence synthesis. Some of these records were described more than once depending on themes of the synthesis. The records were synthesized under the themes of explanatory models of stigma (3 records on labels and 4 records on symptoms and causes), perceived and experienced forms of stigma (7 records on public stigma, 6 records on structural stigma, 2 records on courtesy stigma and 4 records on self-stigma), impact of stigma on help-seeking (6 records) and interventions to reduce stigma (12 records). Only two intervention studies assessed stigma reduction— one study showed reduced discrimination due to improved access to effective mental health care, whereas the other study did not find evidence on reduction of discrimination following a community-based rehabilitation intervention in combination with facility-based care.

Conclusion
There is widespread stigma and discrimination in Ethiopia which has contributed to under-utilization of available mental health services in the country. This should be addressed with contextually designed and effective stigma reduction interventions that engage stakeholders (service users, service providers, community representatives and service developers and policy makers) so that the United Nations universal health coverage goal for mental health can be achieved in Ethiopia.
A Trying Time: Problematic Internet Use (PIU) and its association with depression and anxiety during the COVID-19 Pandemic
Authors: Lakkunarajah Sinduja , Adams Keisha , Pan Amy Y. , Liegl Melodee , Sadhir Mandakini 
Published: June 2022

Abstract
Background
The prevalence of problematic Internet use (PIU) among adolescents and young adults (AYA) was approximately 9–11% before the COVID-19 pandemic. The purpose of this study was to determine the prevalence of PIU among AYAs (especially younger adolescents) during the COVID-19 pandemic using the Problematic and Risky Internet Use Screening Scale (PRIUSS). Additionally, we examined the relationship between PIU, depression and anxiety among AYAs during the same period.

Methods
A descriptive-analysis survey study was completed over a 6-month period from January 4, 2021, to June 30, 2021. It was conducted at a tertiary care Adolescent Medicine Clinic with AYAs age 12–21. The PRIUSS screened for PIU, the PHQ-9A [Patient Health Questionnaire-9A] screened for depression, and the GAD-7 [General Anxiety Disorder-7] screened for generalized anxiety. Fisher’s exact test, the Mann–Whitney test and Spearman correlations were performed.

Results
A positive PRIUSS score was observed in 18% of the 447 participants. Of these participants, 44% had a pre-existing diagnosis of depression, 39% had a pre-existing diagnosis of anxiety and 29% had a pre-existing diagnosis of depression and anxiety. There was a positive correlation between PRIUSS, PHQ-9A and GAD-7 total scores. A higher PRIUSS score was associated with a higher PHQ-9A and GAD-7 score (p < 0.001). There was also a positive correlation between a positive PRIUSS score and a pre-existing diagnosis of depression (p < 0.001).

Conclusions
This study showed a higher prevalence of PIU during the COVID-19 pandemic using the PRIUSS. In addition, a positive correlation between PRIUSS scores and pre-existing diagnosis of depression, positive GAD-7 and PHQ-9A scores was noted. In conclusion, medical providers should consider screening for PIU in AYAs with positive mental health screens.
Diversity-aware unmanned vehicle team arrangement in mobile crowdsourcing
Authors: Li Yu , Feng Haonan , Peng Zhankui , Zhou Li , Wan Jian 
Published: June 2022

AbstractWith the continuous development of mobile edge computing and the improvement of unmanned vehicle technology, unmanned vehicle could handle ever-increasing demands. As a significant application of unmanned vehicle, spatial crowdsourcing will provide an important application scenario, which is about to organize a lot of unmanned vehicle to conduct the spatial tasks by physically moving to its locations, called task assignment. Previous works usually focus on assigning a spatial task to one single vehicle or a group of vehicles. Few of them consider that vehicle team diversity is essential to collaborative work. Collaborative work is benefits from organizing teams with various backgrounds vehicles. In this paper, we consider a spatial crowdsourcing scenario. Each vehicle has a set of skills and a property. The property denotes vehicle’s special attribute (e.g., size, speed or weight). We introduce a concept of entropy to measure vehicle team diversity. Each spatial task (e.g., delivering the take-out, and carrying freight) is under the time and budget constraint, and required a set of skills. We need to assure that the assigned vehicle team is diverse. To address this issue, we first propose a practical problem, called team diversity spatial crowdsourcing (TD-SC) problem which finds an optimal team-and-task assignment strategy. Moreover, we design a framework which includes a greedy with diversity (GD) algorithm and a divide-and-conquer (D&C) algorithm to get team-and-task assignments. Finally, we demonstrate efficiency and effectiveness of the proposed methods through extensive experiments.
A review of national action plans on antimicrobial resistance: strengths and weaknesses
Authors: Willemsen Angela , Reid Simon , Assefa Yibeltal 
Published: June 2022

Abstract
Background
The World Health Organization developed the Global Action Plan on Antimicrobial resistance (AMR) as a priority because of the increasing threat posed to human health, animal health and agriculture. Countries around the world have been encouraged to develop their own National Action Plans (NAPs) to help combat AMR.

The objective of this review was to assess the content of the NAPs and determine alignment with the Global Action Plan on Antimicrobial Resistance using a policy analysis approach.

Body
National Action Plans were accessed from the WHO Library and systematically analysed using a policy analysis approach for actors, process, context and content. Information was assessed using a ‘traffic light’ system to determine agreeance with the five WHO Global Action Plans objectives.
A total of 78 NAPs (70 WHO approved, eight not approved) from the five global regions were analysed. National action plans which provided more information regarding the consultative process and the current situation regarding AMR allowed greater insight to capabilities of the country. Despite the availability of guidelines to inform the development of the plans, there were many differences between plans with the content of information provided. High income countries indicated greater progression with objectives achievement while low and middle-income countries presented the need for human and financial resources.

Conclusion
The national action plans provide an overview of activities underway to combat AMR globally. This analysis reveals how disconnected the process has been and how little information is being gathered globally.
Extraordinary quasi-16-day wave activity from October 2013 to January 2014 with radar observations at mid-latitudes and MERRA2 reanalysis data
Authors: Huang Xiansi , Huang Kaiming , Zhang Shaodong , Huang Chunming , Gong Yun , Cheng Hao 
Published: June 2022

AbstractCombining two meteor radar observations at mid-latitudes and MERRA2 reanalysis data, we report an extraordinary quasi-16-day wave (Q16DW) activity in the mesosphere and lower thermosphere (MLT) from about October 2013 to January 2014. The Q16DW is not only active for a long period, but also unrelated to stratospheric sudden warming (SSW), while 7-year radar observations indicate that strong waves and oscillations in the MLT at mid-latitudes occur generally in winter, and are almost always associated with SSW and stratospheric final warming (SFW), except the extraordinary Q16DW. Meanwhile, during the SSW and SFW in February and March 2014, the observation and reanalysis data show that an intense Q16DW arises in the stratosphere but is not present in the MLT. The two Q16DWs are obviously distinguished from each other. The exceptional Q16DW shows a slowly downward phase progression from the MLT to the troposphere with predominant wavenumber 1, while the second Q16DW has a steeper vertical phase in the stratosphere with predominant wavenumber 2. Although the eastward winds prevail, these Q16DWs are weakened and evanescent in the region with the westward wind and negative refractive index. EP flux vector indicates that these waves originate mainly from the lower atmosphere at mid- and high-latitudes, and are intensified in the middle stratosphere. The first Q16DW may make a little contribution to polar vortex intensification due to small EP flux divergence. However, the Q16DW in the SSW has a strong negative divergence almost in the whole polar stratosphere, implying an important role in the stratospheric zonal wind reduction in the SSW.
Graphical Abstract
Sex determination based on morphometric measurements in yellow-legged gulls (Larus michahellis) around Istanbul
Authors: Pazvant Gülsün , İnce Nazan Gezer , Özkan Ermiş , Gündemir Ozan , Avanus Kozet , Szara Tomasz 
Published: June 2022

AbstractBackgroundYellow-legged gulls (Larus michahellis), commonly found in Istanbul and their surroundings, have a monomorphic plumage, like other gull species. For this reason, sex determination cannot be made externally. In this study, a total of 60 adult Yellow-legged gulls, 33 males, and 27 females, collected from the coastal areas of Istanbul, were examined. Discriminating functions were developed to classify males and females using birds that were previously sexed by DNA analysis and abdominal dissection.ResultsHead length and bill depth were selected to build the discriminant function by the stepwise analysis. The function classified male gulls with an accuracy of 97.0% and females with an accuracy of 92.6%. Head length alone is the most accurate predictor in terms of the percentage of correct sex determination (90.9% for males, 92.6% for females).ConclusionsFunctions that can easily determine sexual dimorphism for the population ofLarus michahellisgulls around Istanbul have been put forward for the first time.
ARG1 as a promising biomarker for sepsis diagnosis and prognosis: evidence from WGCNA and PPI network
Authors: Zhang Jing-Xiang , Xu Wei-Heng , Xing Xin-Hao , Chen Lin-Lin , Zhao Qing-Jie , Wang Yan 
Published: June 2022

Abstract
Background
Sepsis is a life-threatening multi-organ dysfunction caused by the dysregulated host response to infection. Sepsis remains a major global concern with high mortality and morbidity, while management of sepsis patients relies heavily on early recognition and rapid stratification. This study aims to identify the crucial genes and biomarkers for sepsis which could guide clinicians to make rapid diagnosis and prognostication.

Methods
Preliminary analysis of multiple global datasets, including 170 samples from patients with sepsis and 110 healthy control samples, revealed common differentially expressed genes (DEGs) in peripheral blood of patients with sepsis. After Gene Oncology (GO) and pathway analysis, the Weighted Gene Correlation Network Analysis (WGCNA) was used to screen for genes most related with clinical diagnosis. Also, the Protein-Protein Interaction Network (PPI Network) was constructed based on the DEGs and the hub genes were found. The results of WGCNA and PPI network were compared and one shared gene was discovered. Then more datasets of 728 experimental samples and 355 control samples were used to prove the diagnostic and prognostic value of this gene. Last, we used real-time PCR to confirm the bioinformatic results.

Results
Four hundred forty-four common differentially expressed genes in the blood of sepsis patients from different ethnicities were identified. Fifteen genes most related with clinical diagnosis were found by WGCNA, and 24 hub genes with most node degrees were identified by PPI network. ARG1 turned out to be the unique overlapped gene. Further analysis using more datasets showed that ARG1 was not only sharply up-regulated in sepsis than in healthy controls, but also significantly high-expressed in septic shock than in non-septic shock, significantly high-expressed in severe or lethal sepsis than in uncomplicated sepsis, and significantly high-expressed in non-responders than in responders upon early treatment. These all demonstrate the performance of ARG1 as a key biomarker. Last, the up-regulation of ARG1 in the blood was confirmed experimentally.

Conclusions
We identified crucial genes that may play significant roles in sepsis by WGCNA and PPI network. ARG1 was the only overlapped gene in both results and could be used to make an accurate diagnosis, discriminate the severity and predict the treatment response of sepsis.
Development of an interdisciplinary early rheumatoid arthritis care pathway
Authors: Gukova Xenia , Hazlewood Glen S. , Arbillaga Hector , MacMullan Paul , Zimmermann Gabrielle L. , Barnabe Cheryl , Choi May Y. , Barber Megan R. W. , Charlton Alexandra , Job Becky , Osinski Kelly , Hartfeld Nicole M. S. , Knott Marlene W. , Pirani Paris , Barber Claire E. H. 
Published: June 2022

Abstract
Background
To develop an interdisciplinary care pathway for early rheumatoid arthritis (RA) including referral triage, diagnosis, and management.

Methods
Our process was a four-phase approach. In Phase 1, an anonymous survey was electronically distributed to division rheumatologists. This provided data to a small interprofessional working group of rheumatology team members who drafted an initial care pathway informed by evidence-based practice in Phase 2. In Phase 3, an education day was held with approximately 40 physicians (rheumatologists and rheumatology residents), members of our interprofessional team, and two clinic managers to review the proposed care elements through presentations and small group discussions. The care pathway was revised for content and implementation considerations based on feedback received. Implementation of the care pathway and development of strategies for evaluation is ongoing across multiple practice sites (Phase 4).

Results
Our care pathway promotes an approach to patient-centered early RA care using an interdisciplinary approach. Care pathway elements include triage processes, critical diagnostics, pre-treatment screening and vaccinations, and uptake of suggested RA pharmacologic treatment using shared decision-making strategies. Pathway implementation has been facilitated by nursing protocols and evaluation includes continuous monitoring of key indicators.

Conclusion
The ‘Calgary Early RA Care Pathway’ emphasizes a patient-centered and interdisciplinary approach to early RA identification and treatment. Implementation and evaluation of this care pathway is ongoing to support, highest quality care for patients.
Risk-based management framework for microplastics in aquatic ecosystems
Authors: Mehinto Alvine C. , Coffin Scott , Koelmans Albert A. , Brander Susanne M. , Wagner Martin , Thornton Hampton Leah M. , Burton Allen G. , Miller Ezra , Gouin Todd , Weisberg Stephen B. , Rochman Chelsea M. 
Published: June 2022

AbstractMicroplastic particles (MPs) are ubiquitous across a wide range of aquatic habitats but determining an appropriate level of risk management is hindered by a poor understanding of environmental risk. Here, we introduce a risk management framework for aquatic ecosystems that identifies four critical management thresholds, ranging from low regulatory concern to the highest level of concern where pollution control measures could be introduced to mitigate environmental emissions. The four thresholds were derived using a species sensitivity distribution (SSD) approach and the best available data from the peer-reviewed literature. This included a total of 290 data points extracted from 21 peer-reviewed microplastic toxicity studies meeting a minimal set of pre-defined quality criteria. The meta-analysis resulted in the development of critical thresholds for two effects mechanisms: food dilution with thresholds ranging from ~ 0.5 to 35 particles/L, and tissue translocation with thresholds ranging from ~ 60 to 4100 particles/L. This project was completed within an expert working group, which assigned high confidence to the management framework and associated analytical approach for developing thresholds, and very low to high confidence in the numerical thresholds. Consequently, several research recommendations are presented, which would strengthen confidence in quantifying threshold values for use in risk assessment and management. These recommendations include a need for high quality toxicity tests, and for an improved understanding of the mechanisms of action to better establish links to ecologically relevant adverse effects.
Ethics Consultation Requests After Implementation of an Electronic Health Record Order
Authors: Marathe Priya H. , Zhang Hao , Blackler Liz , Stetson Peter D. , Voigt Louis P. , Friedman Danielle Novetsky 
Published: June 2022

PURPOSE:As the role of clinical ethics consultation in health care advances, there are calls to standardize the process of consultation. The Ethics Committee at Memorial Sloan Kettering Cancer Center (MSK) hypothesized that the process of requesting an ethics consultation could be improved by instituting an electronic health record (EHR) order for consultation requests. This report summarizes the impact of adopting an EHR order for ethics consultation requests at MSK.METHODS:This retrospective review of all clinical ethics consultations requested at a tertiary cancer center from May 2017 to February 2020 spans 17 months before and after implementation of an electronic order for consultation requests. Summary statistics are presented using Pearson chi-square analyses with a significance level of 0.05.RESULTS:There was a significant increase in the total number of consultation requests placed after implementation of the EHR order (n = 165, 0.08% of total patients) compared with before (n = 108, 0.05% of total patients; P = .007). The number of consults requested by providers from inpatient ( P = .02) and outpatient ( P = .04) settings significantly increased. The proportion of consults placed by medical versus nonmedical providers remained unchanged ( P = .32).CONCLUSION:In this large single-institution retrospective study, implementation of an EHR order for ethics consultation requests was associated with a significant increase in the number of consultation requests. Implementation of an electronic order may decrease barriers to ethics consultation in diverse practice settings. Further longitudinal, multicenter studies are needed to assess strategies to improve access to clinical ethics consultation for oncology patients.
Disparities in Biomarker Testing and Clinical Trial Enrollment Among Patients With Lung, Breast, or Colorectal Cancers in the United States
Authors: Bruno Debora S. , Hess Lisa M. , Li Xiaohong , Su Eric Wen , Patel Monaliben 
Published: June 2022

PURPOSE Comprehensive tumor biomarker testing is a fundamental step in the selection of highly effective molecularly driven therapies for a variety of solid tumors. The primary objective of this study was to examine racial differences in biomarker testing and clinical trial participation in the United States using a real-world database. METHODS Patients in a real-world deidentified database diagnosed with advanced/metastatic non–small-cell lung cancer (NSCLC), metastatic colorectal cancer (CRC), or metastatic breast cancer were eligible. Biomarker testing and clinical trial participation was compared between Black and White racial groups using chi-squared test and stepwise logistic regression controlling for baseline covariates. RESULTS A total of 23,488 patients met eligibility criteria. Next-generation sequencing (NGS) testing rates differed significantly between White versus Black race before first-line therapy (36.6% v 29.7%, P < .0001) and at any given time (54.7% v 43.8%, P < .0001) in the nonsquamous NSCLC cohort. Similar disparities in NGS testing rates at any time during the study were observed among patients with CRC (White 51.6%; Black 41.8%, P < .0001). No differences were observed in the breast cancer cohort. Patients of Black race were less likely to be treated in a clinical trial in the overall NSCLC cohort when compared with White counterparts (3.9% v 2.1%, P = .0002). A statistically significant relationship between biomarker/NGS testing and clinical trial enrollment was observed in all cohorts ( P < .003) after adjusting for covariates. CONCLUSION In a real-world database, significant disparities in NGS-based testing rates were observed between Black and White races in NSCLC and CRC. NGS and any biomarker testing were both associated with trial enrollment in all cohorts. There is a need for interventions to promote access to comprehensive testing for patients with advanced/metastatic tumors.