bluuebunny/crossref_metadata_2025_split huggingface dataset:
Vortex Formation Time is a Novel Measure for Early Detection of Diastolic Abnormalities in Adolescents with Hypertension
Authors: Dukkipati Haripriya , Sethna Christine , Maisel Kyle , Jones Monique , Kulkarni Aparna 
Published: November 2022

Abstract
Pediatric hypertension (HTN) has demonstrated an upward trend in recent years. Adolescent HTN has been linked to adult HTN, cardiovascular disease, and other health conditions. Thus, it is essential that HTN and its associated cardiac abnormalities be diagnosed and treated early to minimize lifelong adverse effects. In this study, we evaluated whether vortex formation time (VFT), a validated echocardiogram measure of left ventricular diastolic dysfunction, correlated with ambulatory blood pressure monitoring (ABPM) and HTN in adolescents. Echocardiogram data including systolic and diastolic function indices and ABPM data from 2015 to 2022 in adolescents age 13–21 years were analyzed retrospectively. We found that VFT was significantly lower in adolescents with HTN compared to those without (3.69 ± 1.39 vs. 4.50 ± 1.73, p = 0.02). Standard echocardiographic indices of systolic and diastolic function were similar between the two groups. Higher overall systolic blood pressure (SBP) (β = -0.01, CI -0.02, -2.2 x 10− 3, p = 0.02), mean wake SBP (β = -0.01, CI -0.02, -9.4 x 10− 4, p = 0.03) and mean sleep SBP (β = -0.01, CI -0.02, -1.2 x 10− 3, p = 0.03) were significantly associated with lower VFT. This study demonstrates that VFT correlates to ABPM data and can be used as a novel diagnostic measure of early diastolic dysfunction in adolescents with HTN.
A ground penetrating radar denoising method based on CEEMD and wavelet decomposition
Authors: Ma Yong-Min , Liu Yang , Kim Gang-Sop , Jo Won-Hak 
Published: November 2022

Abstract
Ground penetrating radar (GPR) technology is widely used in civil engineering projects such as inspection of concrete buildings, pavement road, bridge, tunnel, and underground utilities (water supply pipes, gas pipes, power cables, sewers, etc.). With the application of GPR becoming more and more extensive, in order to further improve its effectiveness and efficiency, the researches on noise removal, image quality improvement and automatic data interpretation are being actively carried out. In this paper, firstly, the principles of complementary ensemble empirical mode decomposition (CEEMD) and wavelet transform, which are widely used in various signal processing fields, are described in detail. Then, GPR denoising method based on CEEMD and wavelet decomposition is proposed. The CEEMD IMFs of GPR signal separate into the effective signal components and noise ones. The noise components are not completely removed, the effective information are extracted from them by the wavelet denoising technique and then the signal is reconstructed. Finally, the performance of proposed method is verified by numerical simulation and field data analysis.
Dynamic parameterization of a modified SEIRD model to analyze and forecast the dynamics of COVID-19 outbreaks in the United States
Authors: Davarci Orhun O. , Yang Emily Y. , Viguerie Alexander , Yankeelov Thomas E. , Lorenzo Guillermo 
Published: November 2022

Abstract
The rapid spread of the numerous outbreaks of the coronavirus disease 2019 (COVID-19) pandemic has fueled interest in mathematical models designed to understand and predict infectious disease spread, with the ultimate goal of contributing to the decision-making of public health authorities. Here, we propose a computational pipeline that dynamically parameterizes a modified SEIRD (Susceptible-Exposed-InfectedRecovered-Deceased) model using standard daily series of COVID-19 cases and deaths, along with isolated estimates of population-level seroprevalence. We test our pipeline in five heavily impacted states of the US (New York, California, Florida, Illinois, and Texas) between March and August 2020, considering two scenarios with different calibration time horizons to assess the update in model performance as new epidemiologic data becomes available. Our results show a median normalized root mean squared error (NRMSE) of 2.38% and 4.28% in calibrating cumulative cases and deaths in the first scenario, and 2.41% and 2.30% when new data is assimilated in the second scenario, respectively. Then, two-week (four-week) forecasts of the calibrated model resulted in median NRMSE of cumulative cases and deaths of 5.85% and 4.68% (8.60% and 17.94%) in the first scenario, and 1.86% and 1.93% (2.21% and 1.45%) in the second. Additionally, we show that our method provides significantly more accurate predictions of cases and deaths than a constant parameterization in the second scenario (p < 0.05). Thus, we posit that our methodology is a promising approach to analyze the dynamics of infectious disease outbreaks, and that our forecasts could contribute to designing effective pandemic-arresting public health policies.
Neural Circuit Disruptions of Eye Gaze Processing in Autism Spectrum Disorder and Schizophrenia: An Activation Likelihood Estimation Meta-Analysis
Authors: Ibrahim Karim , Iturmendi-Sabater Iciar , Vasishth Maya , Barron Daniel S. , Guardavaccaro MariaRose , Funaro Melissa C. , Holmes Avram , McCarthy Gregory , Eickhoff Simon B. , Sukhodolsky Denis G. 
Published: November 2022

Abstract
Impairment in social cognition, particularly eye gaze processing, is a shared feature common to autism spectrum disorder (ASD) and schizophrenia. However, it is unclear if a convergent neural mechanism also underlies gaze dysfunction across these conditions. The present study examined whether this shared eye gaze phenotype is reflected in a profile of convergent neurobiological dysfunction in ASD and schizophrenia. All fMRI experiments were published between January 1990 and December 2021. Experiments were selected comparing brain responses across domains of gaze processing for ASD or schizophrenia vs healthy controls and reporting whole-brain findings. Fifty-nine experiments from 36 articles met inclusion criteria. Activation likelihood estimation (ALE) meta-analyses were conducted on peak voxel coordinates to identify spatial convergence across disorders. Functional coactivation was conducted with regions emerging as significant using meta-analytic connectivity modeling. Functional decoding was also conducted. The 59 experiments from 36 articles included 629 patients (ASD, schizophrenia) and 613 healthy controls (1242 participants). Across disorders, aberrant activation was found in the right inferior frontal gyrus and right fusiform gyrus during gaze processing. Functional decoding mapped the right inferior frontal gyrus to domains related to cognition and perception, and the right fusiform gyrus to visual perception, spatial cognition, and emotion perception. These regions also showed meta-analytic connectivity to frontoparietal circuitry. Aberrant activation in frontotemporal and frontoparietal circuitry emerged as convergent neural markers in ASD and schizophrenia across domains of gaze processing. These findings have implications for advancing transdiagnostic brain biomarkers to inform diagnosis and targeted treatments for ASD and schizophrenia.
Resectability and Prognosis of Gallbladder Cancer: An experience of 100 cases from a tertiary care centre of Eastern Nepal
Authors: Pandit Narendra , Neupane Durga , Nalbo Dinesh , Bhattarai Sameer , Deo Kunal Bikram , Jaiswal Lokesh Shekher , Adhikary Shailesh 
Published: November 2022

Abstract
Background
Gallbladder cancer (GBC) is the fifth most common neoplasm of the digestive tract and has an overall incidence of 3 per 100000 people. Only 15%-47% of the preoperatively known GBC are suitable for resection. The objective of the study was to investigate the resectability and prognosis of GBC patients.
Methods
It is a prospective observational study including all cases of primary cancers of the gallbladder in the Department of Surgical Gastroenterology, B.P. Koirala Institute of Health Sciences (BPKIHS), over the period from January 2014 to December 2019. The primary endpoint was resectability and overall survival.
Results
During the study period, 100 patients with GBC were reported. The mean age at the time of diagnosis was 52.5 years, with a female predominance (67%). The curative intent resection (radical cholecystectomy) was possible in 30 (30%) patients; while 18 (18%) required palliative surgical treatment. The overall survival of the entire group was 9 months; while those patients who underwent surgery with curative intent had median overall survival of 28 months after median follow-up of 42 months.
Conclusion
This study found that only one-third of patients achieve radical surgery with curative intent. Overall, the prognosis of patients is poor with median survival of less than a year due to the advanced stage disease. Multimodality treatment, screening ultrasound, neo-/adjuvant therapy may improve survival.
Local treatment of acute rhinosinusitis in the era of COVID-19
Authors: Krivopalov A. A. , Ryazantsev S. V. , Turieva V. V. 
Published: November 2022

Introduction. Acute rhinosinusitis accounts for 40 % to 60 % of the morbidity in the structure of ENT pathology. COVID-19 pathogen, similarly to other respiratory viruses, can cause acute rhinosinusitis, which is the most relevant at the present time due to the ongoing pandemic. Viral etiology accounts for 90–98 % of all cases of acute rhinosinusitis. Accordingly, the choice of treatment tactics with antibacterial drugs in a number of cases is unreasonable and leads to the growth of antibiotic resistance. Local antiseptics containing sodium hypochlorite with a high safety profile that do not cause pathogen resistance are used to increase the effectiveness of therapy for acute rhinosinusitis. Objective. To evaluate the effectiveness of nasal spray containing sodium hypochlorite on the duration of the course of exacerbation and severity of acute rhinosinusitis during the epidemiological season. Materials and methods. The study involved 50 patients who were divided into 3 groups: 10 patients (group 1) with acute viral rhinosinusitis (therapy: sodium hypochlorite + decongestants); 20 patients (group 2) with acute bacterial rhinosinusitis (therapy: sodium hypochlorite + systemic antibacterial therapy); 20 patients (group 3) with acute bacterial rhinosinusitis (therapy: nasal lavage with isotonic sea salt solution + systemic antibacterial therapy). Results and discussion. Pathogen eradication – the absence of the original pathogen at the locus of the inflammatory process during dynamic microbiological examination – was found in 14 (35 %) clinical cases: in Group 2 (sodium hypochlorite) – 10 (25 %) and in Group 3 (nasal irrigation with isotonic sea water solution) – 4 (10 %). Conclusions. The results of microbiological studies showed effective antimicrobial properties of sodium hypochlorite when applied to the inflamed mucous membranes, expressed in a statistically significant reduction of bacterial semination of the nasal cavity epithelium.
Video endoscopic methods of laryngeal examination in modern phoniatry
Authors: Stepanova Ju. E. , Gotovyakhina T. V. 
Published: November 2022

Introduction. Modern diagnostics of laryngeal diseases is based on the use of video endoscopic technologies. The authors of the article, having almost thirty years of experience with various methods of video endoscopy, proposed a classification of video endoscopic methods of laryngeal examination. Objective. To develop an algorithm for the application of various video endoscopic methods of laryngeal examination in voice professionals with functional and organic dysphonia. Materials and methods. From 2020 to 2022, 2308 patients aged 18 to 80 years (43.2 ± 11.5) were examined in the phoniatric department of the St. Petersburg Research Institute of ENT. There were 1424 women (61,7 %), 884 men (38,3 %) people. Functional dysphonia was detected in 705 (30,5 %) people, acute and chronic laryngitis in 668 (28,9 %), tumor-like formations in 436 (18,9 %), the remaining nosological forms were diagnosed in 499 (21,7). All the patients turned out to be representatives of voice-speaking professions and complained of dysphonia.For videolaryngoscopy, videolaryngostroboscopy, autofluorescence endoscopy, NBI–endoscopy, equipment from various manufacturers was used. Results. An algorithm for the application of video endoscopic research methods in persons of voice-speech professions with dysphonia has been developed. Overview videolaryngoscopy and videostroboscopy were mandatory research methods for all patients with complaints of voice function. The use of these two methods proved to be sufficient for the diagnosis of functional dysphonia, paresis and paralysis, congenital malformations of the larynx, scar stenosis. In-depth diagnostics and differential diagnostics of tumor-like formations, various forms of chronic laryngitis, benign and malignant formations, in addition to videolaryngoscopy and videostroboscopy, included autofluorescence endoscopy or NBI endoscopy, which revealed the earliest stages of the pathological process. Conclusions. Only the complex application of various methods of video endoscopy of the larynx provided timely diagnosis and early treatment of dysphonia, maximum restoration of voice function, and, consequently, the preservation of professional longevity by persons of voice-speech professions.
Duchenne Muscular Dystrophy Gene Therapy
Authors: Saad Fawzy A. , Saad Jasen F. , Siciliano Gabriele , Merlini Luciano , Angelini Corrado 
Published: November 2022

Abstracts:
Duchenne and Becker muscular dystrophies are allelic X-linked recessive neuromuscular
diseases affecting both skeletal and cardiac muscles. Therefore, owing to their single X chromosome,
the affected boys receive pathogenic gene mutations from their unknowing carrier mothers. Current
pharmacological drugs are palliative that address the symptoms of the disease rather than the genetic
cause imbedded in the Dystrophin gene DNA sequence. Therefore, alternative therapies like gene
drugs that could address the genetic cause of the disease at its root are crucial, which include gene
transfer/implantation, exon skipping, and gene editing. Presently, it is possible through genetic reprogramming
to engineer AAV vectors to deliver certain therapeutic cargos specifically to muscle or other
organs regardless of their serotype. Similarly, it is possible to direct the biogenesis of exosomes to
carry gene editing constituents or certain therapeutic cargos to specific tissue or cell type like brain
and muscle. While autologous exosomes are immunologically inert, it is possible to camouflage AAV
capsids, and lipid nanoparticles to evade the immune system recognition. In this review, we highlight
current opportunities for Duchenne muscular dystrophy gene therapy, which has been known thus far
as an incurable genetic disease. This article is a part of Gene Therapy of Rare Genetic Diseases thematic
issue.
Surgical Advances in Parkinson’s Disease
Authors: Hvingelby Victor S. , Pavese Nicola 
Published: November 2022

Abstract:
While symptomatic pharmacological therapy remains the main therapeutic strategy for Parkinson’s
disease (PD), over the last two decades, surgical approaches have become more commonly
used to control levodopa-induced motor complications and dopamine-resistant and non-motor symptoms
of PD. In this paper, we discuss old and new surgical treatments for PD and the many technological
innovations in this field. We have initially reviewed the relevant surgical anatomy as well as the
pathological signaling considered to be the underlying cause of specific symptoms of PD. Subsequently,
early attempts at surgical symptom control will be briefly reviewed. As the most well-known surgical
intervention for PD is deep brain stimulation, this subject is discussed at length. As deciding on
whether a patient stands to benefit from DBS can be quite difficult, the different proposed paradigms
for precisely this are covered. Following this, the evidence regarding different targets, especially the
subthalamic nucleus and internal globus pallidus, is reviewed as well as the evidence for newer proposed
targets for specific symptoms. Due to the rapidly expanding nature of knowledge and technological
capabilities, some of these new and potential future capabilities are given consideration in
terms of their current and future use. Following this, we have reviewed newer treatment modalities,
especially magnetic resonance-guided focused ultrasound and other potential surgical therapies, such
as spinal cord stimulation for gait symptoms and others. As mentioned, the field of surgical alleviation
of symptoms of PD is undergoing a rapid expansion, and this review provides a general overview of
the current status and future directions in the field.
Treatment of Autism Spectrum Disorders by Mitochondrial-targeted Drug: Future of Neurological Diseases Therapeutics
Authors: Nabi Showkat Ul , Rehman Muneeb U. , Arafah Azher , Taifa Syed , Khan Iqra Shafi , Khan Andleeb , Rashid Summya , Jan Fatimah , Wani Hilal Ahmad , Ahmad Sheikh Fayaz 
Published: November 2022

Abstracts:Autism is a neurodevelopmental disorder with a complex etiology that might involve environmental and genetic variables. Recently, some epidemiological studies conducted in various parts of the world have estimated a significant increase in the prevalence of autism, with 1 in every 59 children having some degree of autism. Since autism has been associated with other clinical abnormalities, there is every possibility that a sub-cellular component may be involved in the progression of autism. The organelle remains a focus based on mitochondria's functionality and metabolic role in cells. Furthermore, the mitochondrial genome is inherited maternally and has its DNA and organelle that remain actively involved during embryonic development; these characteristics have linked mitochondrial dysfunction to autism. Although rapid stride has been made in autism research, there are limited studies that have made particular emphasis on mitochondrial dysfunction and autism. Accumulating evidence from studies conducted at cellular and sub-cellular levels has indicated that mitochondrial dysfunction's role in autism is more than expected. The present review has attempted to describe the risk factors of autism, the role of mitochondria in the progression of the disease, oxidative damage as a trigger point to initiate mitochondrial damage, genetic determinants of the disease, possible pathogenic pathways and therapeutic regimen in vogue and the developmental stage. Furthermore, in the present review, an attempt has been made to include the novel therapeutic regimens under investigation at different clinical trial stages and their potential possibility to emerge as promising drugs against ASD.
Neonatal Anemia
Authors: Juul Sandra E. , German Kendell R. 
Published: November 2022

Abstract:
All neonates experience a downtrend in their hematocrit values immediately following the birth through normal falls in erythropoietin (Epo) production, transition to adult hemoglobin, and hemodilution with somatic growth. However, this drop is more pronounced in critically ill and preterm neonates and can lead to potentially pathologic anemia that impairs tissue oxygen delivery. In this review, we highlight the mechanisms underlying physiologic anemia and anemia of prema-turity and briefly review the evidence for the treatment of anemia in the neonatal population, includ-ing the use of red blood cell transfusions, erythropoietic stimulating agents, and iron supplementa-tion.
Relevance of Machine Learning to Predict the Inhibitory Activity of Small Thiazole Chemicals on Estrogen Receptor
Authors: Jayaprakash Venkatesan , Saravanan Thangavelu , Ravindran Karuppaiyan , Prabha Thangavelu , Selvaraj Jubie , Jayapalan Sudeepan , Chaitanya M.V.N.L. , Sivakumar Thangavel 
Published: November 2022

Background:Drug discovery requires the use of hybrid technologies for the discovery of new chemical substances. One of those interesting strategies is QSAR via applying an artificial intelligence system that effectively predicts how chemical alterations can impact biological activity via in-silico.Aim:Our present study aimed to work on a trending machine learning approach with a new opensource data analysis python script for the discovery of anticancer lead via building the QSAR model by using 53 compounds of thiazole derivatives.Methods:A python script has been executed with 53 small thiazole chemicals using Google collaboratory interface. A total of 82 CDK molecular descriptors were downloaded from “chemdes” web server and used for our study. After training the model, we checked the model performance via cross-validation of the external test set.Results:The generated QSAR model afforded the ordinary least squares (OLS) regression as R2 = 0.542, F=8.773, and adjusted R2 (Q2) =0.481, std. error = 0.061, reg.coef_ developed were of, - 0.00064 (PC1), -0.07753 (PC2), -0.09078 (PC3), -0.08986 (PC4), 0.05044 (PC5), and reg.intercept_ of 4.79279 developed through stats models, formula module. The performance of test set prediction was done by multiple linear regression, support vector machine, and partial least square regression classifiers of sklearn module, which generated the model score of 0.5424, 0.6422 and 0.6422 respectively.Conclusion:Hence, we conclude that the R2values (i.e. the model score) obtained using this script via three diverse algorithms were correlated well and there is not much difference between them and may be useful in the design of a similar group of thiazole derivatives as anticancer agents.