bluuebunny/crossref_metadata_2025_split huggingface dataset:
ProBioQuest: a database and semantic analysis engine for literature, clinical trials, and patents related to probiotics
Authors: Chan Po Lam , Lauw Susana , Ma Ka Lee , Kei Nelson , Ma Ka Leong , Wong Yiu On , Lam Ho Yan , Ting Rina , Yau Tsz Kwan , Nong Wenyan , Huang Dandan , Xie Yichun , Keung Cheung Peter Chi , Kwan Hoi Shan 
Published: February 2022

AbstractThe use of probiotics to improve health via the modulation of gut microbiota has gained wide attention. The growing volume of investigations of probiotic microorganisms and commercialized probiotic products has created the need for a database to organize the health-promoting functions driven by probiotics reported in academic articles, clinical trials, and patents. Currently, no such database is available. We constructed ProBioQuest to collect up-to-date literature related to probiotics from PubMed.gov, ClinicalTrials.gov, and Patents View. More than 2.8 million articles were collected by the end of 2021: PubMed.gov: 2 656 818; Clinical Trials.gov: 205 349; Patents View: 32 536. Automated information technology-assisted procedures enabled us to collect the data continuously, providing the most up-to-date information. Statistical functions and semantic analyses are provided on the website as an advanced search engine, which contributes to the semantic tool of this database for information search and analyses. The semantic analytical output provides categorised search results and functions to enhance further analysis. A keyword bank is included which can display multiple tables of contents. Users can select keywords from different displayed categories to achieve easy filtered searches. Additional information on the searched items can be browsed via the link-out function. ProBioQuest is not only useful to scientists and health professionals, but also to dietary supplement manufacturers and the general public. In this paper, the method we used to build this database-web system is described. Applications of ProBioQuest for several literature-based analyses of probiotics are included as examples of the various uses to which this search engine can be put. ProBioQuest can be accessed free of charge at http://kwanlab.bio.cuhk.edu.hk/PBQ/.Database URLhttp://kwanlab.bio.cuhk.edu.hk/PBQ/
Biomechanical dependence of SARS-CoV-2 infections
Authors: Paul Alexandra , Kumar Sachin , Kaoud Tamer S. , Pickett Madison , Bohanon Amanda L. , Zoldan Janet , Dalby Kevin N. , Parekh Sapun H. 
Published: February 2022

AbstractOlder people have been disproportionately vulnerable to the current SARS-CoV-2 pandemic, with an increased risk of severe complications and death compared to other age groups. A mix of underlying factors has been speculated to give rise to this differential infection outcome, including changes in lung physiology, weakened immunity, and severe immune response. Our study focuses on the impact of biomechanical changes in lungs that occur as individuals age, i.e., the stiffening of the lung parenchyma and increased matrix fiber density. We used hydrogels with an elastic modulus of 0.2 and 50 kPa and conventional tissue culture surfaces to investigate how infection rate changes with parenchymal tissue stiffness in lung epithelial cells challenged with SARS-CoV-2 Spike (S) protein pseudotyped lentiviruses. Further, we employed electrospun fiber matrices to isolate the effect of matrix density. Given the recent data highlighting the importance of alternative virulent strains, we included both the native strain identified in early 2020 and an early S protein variant (D614G) that was shown to increase the viral infectivity markedly. Our results show that cells on softer and sparser scaffolds, closer resembling younger lungs, exhibit higher infection rates by the WT and D614G variant. This suggests that natural changes in lung biomechanics do not increase the propensity for SARS-CoV-2 infection and that other factors, such as a weaker immune system, may contribute to increased disease burden in the elderly.
Functional connectivity of the inferior frontal gyrus: A meta-analytic connectivity modeling study
Authors: Bulut Talat 
Published: February 2022

AbstractBackgroundNeurocognitive models of language processing highlight the role of the left inferior frontal gyrus (IFG) in the functional network underlying language. Furthermore, neuroscience research has shown that IFG is not a uniform region anatomically, cytoarchitectonically or functionally. However, no previous study explored the language-related functional connectivity patterns of different IFG subdivisions using a meta-analytic connectivity approach.PurposeThe present meta-analytic connectivity modeling (MACM) study aimed to identify language-related coactivation patterns of the left and right IFG subdivisions.MethodSix regions of interest (ROIs) were defined using a probabilistic brain atlas corresponding to pars opercularis (BA44), pars triangularis (BA45) and pars orbitalis (Fo6&7) of IFG in both hemispheres. The ROIs were used to search the BrainMap functional database to identify neuroimaging experiments with healthy, right-handed participants reporting language-related activations in each ROI. Activation likelihood estimation analyses were then performed on the foci extracted from the identified studies to compute functional convergence for each ROI, which was also contrasted with the other ROIs within the same hemisphere. In addition, a behavioral analysis was conducted to determine functional specificity for language subdomains within each ROI.ResultsA primarily left-lateralized functional network was revealed for the left and right IFG subdivisions. The left IFG ROIs exhibited a more robust coactivation pattern than the right IFG ROIs. In particular, the left posterior-dorsal IFG (BA44) was associated with the most extensive coactivation pattern involving bilateral frontal, bilateral parietal, left temporal, left subcortical (thalamus and putamen), and right cerebellar regions, while the left anterior-ventral IFG (BA45 and Fo6&7) revealed a predominantly left-lateralized involvement of frontotemporal regions.ConclusionThe findings align with the neurocognitive models of language processing that propose a division of labor among the left IFG subdivisions and their respective functional networks. Also, the opercular part of left IFG (BA44) stands out as a major hub in the language network with connections to diverse cortical, subcortical and cerebellar structures.
Development of assessment framework for environmental sustainability in higher education institutions
Authors: Menon Shalini , Suresh M. 
Published: February 2022

Purpose
Unsustainable actions have resulted in the deterioration of the environment. Higher education institutions are social entities responsible for developing future leaders who have the skills and abilities to solve societal challenges. This study aims to develop a conceptual assessment model of environmental sustainability in higher education and apply the model to test the environmental sustainability level of a higher education institution.

Design/methodology/approach
The fuzzy logic method is used to develop the conceptual model, and a higher education institution in India was selected for evaluating the environmental sustainability level.

Findings
The fuzzy environmental sustainability index for the higher education institution selected for the study was computed as (3.58, 4.95, 6.33). The computed value identifies the institution as “environmentally sustainable”. The calculation of the fuzzy performance importance index further helped in identifying weak attributes that need improvement.

Research limitations/implications
The result of this study would help the management understand their current environmental sustainability level and take corrective measures to improve the weak attributes. It would also assist the institution in reworking its processes and practices.

Originality/value
This study has contributed to the literature of environmental sustainability assessment by creating a conceptual model for evaluating environmental sustainability in higher education. This model can be applied to any higher education institution.
Title: Intergenerational gaps in women’s grassroots peacebuilding in Ghana: a critique of “inclusive peacebuilding”
Authors: Paalo Sebastian Angzoorokuu 
Published: February 2022

Purpose
The purpose of this paper is to examine the idea of inclusion in women’s bottom-up peacebuilding in Ghana. Inspired by the growing importance of “inclusion” and “local empowerment” in the discourse and practice of local ownership in peacebuilding, this paper seeks to investigate the scope and degree of inclusion of key actors such as women and youth, and how that affects peacebuilding and sustainable peace in some conflict-affected zones.

Design/methodology/approach
This study adopts a cross-sectional case study design and qualitative strategy. It is based on semi-structured interviews and focus group discussions conducted with actors who have been engaged in grassroots peacebuilding in Ghana and West Africa. The analysis was largely inductive, identifying emerging themes and patterns in the research data.

Findings
The findings indicate that young women are usually absent or not engaged meaningfully in the mobilization of women and youth in the “inclusive” grassroots peacebuilding in Ghana. This is due to the prevalence of deep-seated cultural and political prejudices or stereotypes about women in the areas studied. As these local constructs and thus practices are difficult to change or challenge, peacebuilding non-governmental organizations (NGOs) usually deploy innovative ways by mobilizing socially constructed women’s positionalities – as “whistleblowers,” “cross-ethnic/cross-cultural actors” and “socially networked actors” – in ways that promote women in contemporary peacebuilding discourses and practices. Through mobilizing these stereotypes (to forestall possible provocation, especially from dominant actors or gatekeepers), peacebuilding NGOs have subtly positioned women centrally within a vibrant peace infrastructure in Ghana. Yet, due to the dominance of some patriarchal sociopolitical structures, only older women and young men occupy the spaces for women and youth’s peacebuilding.

Originality/value
To the best of the author’s knowledge, this is one of the first research papers to question not only the scope but also the degree of inclusion and participation of women in peacebuilding in sub-Sahara Africa. This has nuanced scholarly debates on the subject and encouraged the development of innovative programmes targeted at a more comprehensive gendered and youth-ed inclusion to address the inequality gap in peacebuilding discourses and practices.
Lean R&D practices and its impact on organizational performance: evidence from R&D-based manufacturers in Malaysia
Authors: Tan Owee Kowang , Mohd Hamel Nabila , Ong Choon Hee , Goh Chin Fei , Rasli Amran 
Published: February 2022

PurposeThe study aims to explore how lean research and development (R&D) tools and techniques (T&T: i.e. R&D hard practices) affect the relationship between lean R&D soft practices and organization performance within R&D-based manufacturing firms in Malaysia.Design/methodology/approachThe current study is a quantitative study that utilized an online survey questionnaire for data collection. Data were collected based on a cross-sectional survey of R&D managers from 102 R&D-based manufacturing firms in Malaysia. Structural equation modeling (SEM) was used to test the impact of lean R&D soft and hard practices on firms' performance.FindingsAs per the study findings, it was determined that T&T of lean R&D was significant mediator in the relationship between lean R&D soft practices (i.e. managerial practices, transformational leadership, financial capability and supplier involvement) and R&D firms' performance.Practical implicationsThe study delivers an important message to R&D companies that lean practices could be applied in R&D environments to drive organization performance.Originality/valueThe study extends the knowledge regarding lean principles and framework beyond the domains of production and services. The study offers new conceptual contribution in term of lean principles and framework in R&D environments by introducing the role of lean R&D tools and technique to enhance the effects of lean R&D practices on organization performance.
The TRISEC framework for optimizing conversational agent design across search, experience and credence service contexts
Authors: Blazevic Vera , Sidaoui Karim 
Published: February 2022

PurposeService providers increasingly use conversational agents (CAs), such as chatbots, to effectively communicate with customers while managing interaction costs and providing round-the-clock customer service. Yet, the adoption and implementation of such agents in service contexts remains a hit-and-miss, and firms often struggle to balance their CAs implementation complexities and costs with relation to their service objectives, technology design and customer experiences. The purpose of this paper is to provide guidance on optimizing CA design, therefore, the authors develop a conceptual framework, TRISEC, that integrates service logic, technology design and customer experience to examine the implementation of CA solutions in search, experience and credence (SEC) contexts.Design/methodology/approachThe paper draws on service marketing and communications research, combining the service context classification scheme of search, experience and credence and the technology infused service marketing triangle foci (service, technology and customer) in its conceptual development.FindingsThe authors find that an opportunity exists in recognizing the importance of context when designing CAs and aiming to achieve a balance between service objectives, technology design and customer experiences.Originality/valueThis study contributes to service management and communications research literature by providing interactive service marketing researchers with the highly generalizable TRISEC framework to aid in optimizing CA design and implementation in interactive customer communication technologies. Furthermore, the study provides an array of future research avenues. From a practical perspective, this study aims at providing managers with a means to optimize CA technology design while maintaining a balance between customer centricity and implementation complexity and costs in different service contexts.
Renewing models for change
Authors: Pregmark Johanna E. 
Published: February 2022

PurposeThis paper aims to contribute to discussion around the need for improved models for change in a rapidly changing world. It also aims to provide insights for further discussion around how a Nordic management approach can relate to the need for new change ideas. Since Lewin proposed that change requires unfreezing, moving and refreezing, several changes in models have been introduced. Many models include similar factors such as the need for a vision, a clear process and to motivate change. These change factors are investigated in this paper and related to a fast-paced, uncertain and volatile environmentDesign/methodology/approachBased on a collaborative research approach, engaging with leaders in five organizations, all headquartered in the Nordic countries, this paper examines problems with traditional change models in a contemporary context as well as how these challenges could be handled.FindingsThis paper concludes that leaders still find value in traditional models but see that these models need to be adapted to include elements of more recent research. This paper suggests tweaks in traditional change factors and ends with a proposition with a renewed model for change.Originality/valueThe ideas in this paper could be seen as a bridge between traditional and modern models – a bridge that seems to be needed in practice. It draws on action research and close relationships with top management, as they are working with change – potentially giving the study a unique angle on a practical, widespread problem: succeeding with change
Parasite dynamics in North American monarchs predicted by host density and seasonal migratory culling
Authors: Majewska Ania A. , Davis Andrew K. , Altizer Sonia , de Roode Jacobus C. 
Published: February 2022

AbstractInsect–pathogen dynamics can show seasonal and inter‐annual variations that covary with fluctuations in insect abundance and climate. Long‐term analyses are especially needed to track parasite dynamics in migratory insects, in part because their vast habitat ranges and high mobility might dampen local effects of density and climate on infection prevalence.Monarch butterfliesDanaus plexippusare commonly infected with the protozoanOphryocystis elektroscirrha(OE). Because this parasite lowers monarch survival and flight performance, and because migratory monarchs have experienced declines in recent decades, it is important to understand the patterns and drivers of infection.Here we compiled data onOEinfection spanning 50 years, from wild monarchs sampled in the United States, Canada and Mexico during summer breeding, fall migrating and overwintering periods. We examined eastern versus western North American monarchs separately, to ask how abundance estimates, resource availability, climate and breeding season length impact infection trends. We further assessed the intensity of migratory culling, which occurs when infected individuals are removed from the population during migration.Average infection prevalence was four times higher in western compared to eastern subpopulations. In eastern North America, the proportion of infected monarchs increased threefold since the mid‐2000s. In the western region, the proportion of infected monarchs declined sharply from 2000 to 2015, and increased thereafter. For both eastern and western subpopulations, years with greater summer adult abundance predicted greater infection prevalence, indicating that transmission increases with host breeding density. Environmental variables (temperature and NDVI) were not associated with changes in the proportion of infected adults. We found evidence for migratory culling of infected butterflies, based on declines in parasitism during fall migration. We estimated that tens of millions fewer monarchs reach overwintering sites in Mexico as a result ofOE, highlighting the need to consider the parasite as a potential threat to the monarch population.Increases in infection among eastern North American monarchs post‐2002 suggest that changes to the host’s ecology or environment have intensified parasite transmission. Further work is needed to examine the degree to which human practices, such as mass caterpillar rearing and the widespread planting of exotic milkweed, have contributed to this trend.
Vaccine hesitancy and emerging parental norms: A qualitative study in Taiwan
Authors: Kuan Chen‐I 
Published: February 2022

AbstractThis article reports a qualitative study on vaccine hesitancy in Taiwan. Based on its findings, this research illuminates the close relationships between expanding vaccine hesitancy and current parental norms. It answers the following questions: how do parents understand their roles and responsibilities regarding childhood vaccination under new parental norms? How do new parental norms interweave with other social contexts to shape parental practices of childhood vaccination? This research collected data from March 2018 to July 2020. This research observed lectures and activities concerning childhood vaccination organised by parental groups and interviewed 24 parents and three CDC professionals. Results show that ‘uniqueness of every child’, ‘informed decision‐making’ and ‘intensive parenthood’ are three essential elements in contemporary parental norms that significantly influence parents’ experiences regarding childhood vaccination. Under the norms, parents perceive their responsibility to inform themselves and make decisions most suitable for their children. Results also highlight the tension when health authorities failed to recognise new parental roles in childhood vaccination. The current lack of communication on childhood vaccination causes parents’ anxiety even among those who comply with vaccination policy. Health authorities and professionals should pay attention to new parental norms affecting people's childhood vaccination practices and develop suitable communication strategies.
Epithelial and sensory mechanisms of nasal hyperreactivity
Authors: Velasco Enrique , Delicado‐Miralles Miguel , Hellings Peter W. , Gallar Juana , Van Gerven Laura , Talavera Karel 
Published: February 2022

Abstract“Nasal hyperreactivity” is a key feature in various phenotypes of upper airway diseases, whereby reactions of the nasal epithelium to diverse chemical and physical stimuli are exacerbated. In this review, we illustrate how nasal hyperreactivity can result from at least three types of mechanisms: (1) impaired barrier function, (2) hypersensitivity to external and endogenous stimuli, and (3) potentiation of efferent systems. We describe the known molecular basis of hyperreactivity related to the functional impairment of epithelial cells and somatosensory innervation, and indicate that the thermal, chemical, and mechanical sensors determining hyperreactivity in humans remain to be identified. We delineate research directions that may provide new insights into nasal hyperreactivity associated with rhinitis/rhinosinusitis pathophysiology and therapeutics. The elucidation of the molecular mechanisms underlying nasal hyperreactivity is essential for the treatment of rhinitis according to the precepts of precision medicine.
Bruton's tyrosine kinase inhibition—An emerging therapeutic strategy in immune‐mediated dermatological conditions
Authors: Mendes‐Bastos Pedro , Brasileiro Ana , Kolkhir Pavel , Frischbutter Stefan , Scheffel Jörg , Moñino‐Romero Sherezade , Maurer Marcus 
Published: February 2022

AbstractBruton's tyrosine kinase (BTK), a member of the Tec kinase family, is critically involved in a range of immunological pathways. The clinical application of BTK inhibitors for B‐cell malignancies has proven successful, and there is strong rationale for the potential benefits of BTK inhibitors in some autoimmune and allergic conditions, including immune‐mediated dermatological diseases. However, the established risk‐to‐benefit profile of “first‐generation” BTK inhibitors cannot be extrapolated to these emerging, non‐oncological, indications. “Next‐generation” BTK inhibitors such as remibrutinib and fenebrutinib entered clinical development for chronic spontaneous urticaria (CSU); rilzabrutinib and tirabrutinib are being studied as potential treatments for pemphigus. Promising data from early‐phase clinical trials in CSU suggest potential for these agents to achieve strong pathway inhibition, which may translate into measurable clinical benefits, as well as other effects such as the disruption of autoantibody production. BTK inhibitors may help to overcome some of the shortcomings of monoclonal antibody treatments for immune‐mediated dermatological conditions such as CSU, pemphigus, and systemic lupus erythematosus. In addition, the use of BTK inhibitors may improve understanding of the pathophysiological roles of mast cells, basophils, and B cells in such conditions.