bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Association of Inflammatory Factors With Peripheral Neuropathy: The Study of Women's Health Across the Nation
Authors: Sanders Wade M , Harlow Siobán D , Ylitalo Kelly R , Lange-Maia Brittney S , Leis Aleda M , McConnell Daniel S , Karvonen-Gutierrez Carrie A 
Published: October 2022

Abstract

Purpose
Previous work has focused on the role of diabetes in peripheral neuropathy (PN), but PN often occurs before, and independently from, diabetes. This study measures the association of cardiometabolic and inflammatory factor with PN, independent of diabetes.

Methods
Study of Women's Health Across the Nation participants (n = 1910), ages 60 to 73 (mean 65.6) were assessed for PN by symptom questionnaire and monofilament testing at the 15th follow-up visit (V15). Anthropometric measures and biomarkers were measured at study baseline approximately 20 years prior, and C-reactive protein (CRP) and fibrinogen were measured longitudinally. Log-binomial regression was used to model the association between metabolic syndrome (MetS), obesity (≥35 body mass index), CRP, and fibrinogen with PN, adjusting for sociodemographic and health behavior measures.

Results
Baseline MetS [prevalence ratio (PR) 1.79, 95% CI (1.45, 2.20)], obesity [PR 2.08 (1.65, 2.61)], median CRP [PR 1.32 per log(mg/dL), (1.20, 1.45)], and mean fibrinogen (PR 1.28 per 100 mg/dL, (1.09, 1.50)] were associated with PN symptoms at V15. After excluding participants with baseline diabetes or obesity, MetS [PR 1.59 (1.17, 2.14)] and CRP [PR 1.19 per log(mg/dL), (1.06, 1.35)] remained statistically significantly associated with PN. There was a negative interaction between MetS and obesity, and the association between these conditions and PN was mediated by CRP.

Conclusions
Cardiometabolic factors and inflammation are significantly associated with PN, independent of diabetes and obesity. CRP mediates the relationship of both obesity and MetS with PN, suggesting an etiological role of inflammation in PN in this sample.
Effects of the COVID-19 pandemic on university-based research conduct and training: Exploring university-based researchers’ perspectives and experiences
Authors: Ory Marcia G. , Lee Shinduk , Radcliff Tiffany A. , Jani Sagar , Rice-Ficht Allison , Waer Amy L. 
Published: October 2022

Background: The academic environment is critical for advancing knowledge through research and training of students who will serve as researchers, advocates, and leaders in the future, yet there is limited data on how the higher institution-based research enterprise is being impacted by the coronavirus disease 2019 (COVID-19) pandemic. The current study examines the perceived and expected impact of COVID-19 on engaging in a higher education institution setting, particularly focusing on student engagement in research and conduct of human subject research (HSR). Method: The authors collected an online survey with faculty and staff in a large US university system focused on education, research, and service (6/8/2020-7/10/2020; N=709). The authors performed bivariate and multivariable logistic regression models to examine the differences in research impact by HSR. Results: The majority of survey respondents (i.e., faculty and staff from a large US university system) perceived and expected at least some impact of COVID-19 on research and reported the impact to be negative. Researchers reported increased challenges in recruiting students for research activities and providing research-related learning opportunities for students. While COVID-19 impacted both HSR and non-HSR, HSR investigators have been disproportionately impacted by the pandemic. Conclusions: Efforts are needed to further understand and overcome research challenges so that the university-based research environment can flourish for all researchers across disciplines and overcome the potentially lost learning opportunities for students. Lessons learned will help address future challenges to academic research activities and providing student research training.
Implementation of telemedicine consultations for people with mental health conditions in the community: a protocol for a systematic review
Authors: Galvin Emer , Desselle Shane , Gavin Blánaid , Quigley Etain , Flear Mark , Kilbride Ken , McNicholas Fiona , Cullinan Shane , Hayden John 
Published: October 2022

Background: The COVID-19 pandemic response has led to an exponential increase in the use and spread of telemedicine internationally. In community mental health care settings, telemedicine services were implemented within a few weeks, with little time for rigorous planning. Despite the reported acceptability of telemedicine by patients and clinicians, barriers to its implementation have come to light. There is now a need to investigate these barriers, and facilitators, as telemedicine begins to show potential promise beyond the pandemic. We propose a review that aims to identify the factors affecting the implementation of telemedicine consultations for patients with mental health conditions in the community. Methods: A systematic review will be conducted and reported according to the PRISMA guidelines. Five electronic databases will be searched using a pre-defined search strategy from 2016 to 2021. Only studies of synchronous, interactive telemedicine consultations conducted via video, phone or live messaging between patients and providers will be included. Quantitative, qualitative and mixed methods studies will be eligible for inclusion. Only studies published in the English language will be included. Titles and abstracts will be screened by two reviewers. Full text articles will be screened by two reviewers. The methodological quality of studies will be assessed using the Mixed Method Appraisal Tool (MMAT) by two reviewers. Data will be extracted and tabulated to address the aims of the review. A narrative synthesis will be conducted and reported factors will be mapped to the domains of the Consolidated Framework for Implementation Research (CFIR). Conclusion: By identifying the factors that influence the implementation of telemedicine consultations for patients with mental conditions in the community, consideration can be given to both barriers and facilitators that could be addressed in future mental health services planning. PROSPERO registration: CRD42021273422 (04/10/2021)
Problem-solving in virtual environment simulations prior to direct instruction for differential diagnosis in medical education: An experimental study
Authors: Fässler Christian , Sinha Tanmay , Schmied Christian Marc , Goldhahn Jörg , Kapur Manu 
Published: October 2022

Background: Despite acquiring vast content knowledge about the functioning of the human body through university teaching, medical students struggle to transfer that knowledge to one of the core disciplinary practices – differential diagnosis (DD). The authors aimed to overcome this problem by implementing computer-based virtual environment (CVE) simulations in medical education courses. Methods: In an experimental study, the authors compared problem-solving in medical CVEs prior to instruction with an instruction-first approach. They compared the effects on isomorphic testing and transfer performance of clinical knowledge (CK) and clinical reasoning skills (CRS) as well as evoked learning mechanisms. The study took place in spring 2021 with undergraduate medical students in the scope of a medical trajectory course. Due to COVID-19 issues participants completed all study activities remotely from home. Results: The authors did not find any learning activity sequence to be superior to the other. However, when looking at the two learning activities individually, they found that problem-solving in CVEs as well as direct instruction are equally effective at imparting content knowledge, whereas problem-solving in CVE with formative feedback imparts clinical reasoning skills better than mere instruction. Conclusions: The findings indicate that only the problem-solving learning activity in CVEs imparts CRS and that such skills cannot be taught by theoretical instruction only. The present study has a high level of ecological validity because it took place in a realistic setting where students had to perform all learning and testing tasks autonomously.
Augmented reality limitations in the tourism sector
Authors: Huertas Assumpció , Gonzalo Iglesia Jan 
Published: October 2022

Technology development and augmented reality (AR) applications emergence have transformed the experiential process in tourism. ar offers enormous potential and advantages to the tourism sector, especially after covid-19. However, this study aims to find and gain further knowledge of ar’s limitations. This research analysed the AR platform Imageen Tarraco (Tarragona, Spain) based on a users’ survey, in-depth interviews and a focus group (fg). The analysis showed the lack of knowledge and the technical problems as the application’s most challenging limitations and their causes. It also allowed categorizing the overall challenges by type of public and delving into the factors that promote their use or non-use. The study provides useful recommendations to ar platform creators and the destination management organizations (dmos) that implement them.
Construção cromática e linguagem gráfica de rótulos cromolitográficos brasileiros (1876-1919)
Authors: Barros Helena De 
Published: October 2022

Esta pesquisa trata das estratégias de construção cromática da cromolitografia, técnica de impressão histórica caracterizada pela separação de cor manual e empírica. Foram investigadas coleções de rótulos de produtos brasileiros em instituições públicas, produzidos entre 1876 e 1919. Procedimentos de pesquisa foram apoiados por técnicas de observação e registro microscópico, analisando 100 amostras, apresentadas em narrativas verbal e visual. Contribui-se para os campos do design e da memória gráfica, contextualizados na cultura material e nas linguagens visuais decorrentes de técnicas produtivas.
Entre metáforas e mandalas: efeitos do uso de elementos-surpresa no desenvolvimento de RGSs (representações gráficas de síntese)
Authors: Padovani Stephania 
Published: October 2022

A dinâmica envolvendo RGSs (representações gráficas de síntese) vêm sendo utilizada em disciplinas teóricas em Design para fomentar a interação entre estudantes. Apesar de seu caráter inovador, quando comparada a práticas mais tradicionais como seminários e produção de resumos, a repetição pode torná-la monótona. Nesse sentido, optamos por inserir elementos-surpresa no início da produção de cada RGS. Esse estudo investiga os efeitos do elemento-surpresa sobre a dinâmica. Os resultados demonstraram que houve uma maior diversidade de atividades, maior colaboração e motivação dos estudantes. Entre metáforas e mandalas: efeitos do uso de elementos-surpresa no desenvolvimento de RGSs (representações gráficas de síntese)
Affordability of essential medicines: The case of fluoride toothpaste in 78 countries
Authors: Gkekas Athanasios , Varenne Benoit , Stauf Nicole , Benzian Habib , Listl Stefan 
Published: October 2022

Background
Fluoride toothpaste (FT) has recently been included in the WHO Model List of Essential Medicines. Whereas it is essential for preventing dental caries, its current affordability around the globe remains unclear. This study aimed to analyse the affordability of FT in as many as possible countries worldwide, to capture the extent of variations in FT affordability between high-, middle- and low-income countries.

Methods
A standardized protocol was developed to collect country-specific information about the characteristics of the cheapest available FT at a regular point of purchase. 82 members of the WHO Global Oral Health Network of Chief Dental Officers (CDOs), directors of WHO Collaborative Centres and other oral health experts collected data using mobile phone technology. In line with established methodologies to assess affordability, the Fluoride Toothpaste Affordability Ratio (FTAR) was calculated as the expenditure associated with the recommended annual consumption of FT relative to the daily wage of the lowest-paid unskilled government worker (FTAR >1 = unaffordable spending on fluoride toothpaste).

Results
There are significant differences in the affordability of FT across 78 countries. FT was strongly affordable in high-income countries, relatively affordable in upper middle-income countries, and strongly unaffordable in lower middle-income and low-income countries. The affordability of FT across WHO Regions was dependent upon the economic mix of WHO Regions’ member states.

Conclusion
FT is still unaffordable for many people, particularly in low-income settings. Strategies to improve the universal affordability of FT should be part of health policy decisions in order to contribute to reducing dental caries as a global public health problem.
Is there an association between hospital staffing levels and inpatient-COVID-19 mortality rates?
Authors: Al-Amin Mona , Islam Md. Nazmul , Li Kate , Shiels Natalie , Buresh John 
Published: October 2022

Objective
This study aims to investigate the relationship between RNs and hospital-based medical specialties staffing levels with inpatient COVID-19 mortality rates.

Methods
We relied on data from AHA Annual Survey Database, Area Health Resource File, and UnitedHealth Group Clinical Discovery Database. In phase 1 of the analysis, we estimated the risk-standardized event rates (RSERs) based on 95,915 patients in the UnitedHealth Group Database 1,398 hospitals. We then used beta regression to analyze the association between hospital- and county- level factors with risk-standardized inpatient COVID-19 mortality rates from March 1, 2020, through December 31, 2020.

Results
Higher staffing levels of RNs and emergency medicine physicians were associated with lower COVID-19 mortality rates. Moreover, larger teaching hospitals located in urban settings had higher COVID-19 mortality rates. Finally, counties with greater social vulnerability, specifically in terms of housing type and transportation, and those with high infection rates had the worst patient mortality rates.

Conclusion
Higher staffing levels are associated with lower inpatient mortality rates for COVID-19 patients. More research is needed to determine appropriate staffing levels and how staffing levels interact with other factors such as teams, leadership, and culture to impact patient care during pandemics.
Safety culture and adverse event reporting in Ghanaian healthcare facilities: Implications for patient safety
Authors: Abuosi Aaron Asibi , Poku Collins Atta , Attafuah Priscilla Y. A. , Anaba Emmanuel Anongeba , Abor Patience Aseweh , Setordji Adelaide , Nketiah-Amponsah Edward 
Published: October 2022

IntroductionRecognizing the values and norms significant to healthcare organizations (Safety Culture) are the prerequisites for safety and quality care. Understanding the safety culture is essential for improving undesirable workforce attitudes and behaviours such as lack of adverse event reporting. The study assessed the frequency of adverse event reporting, the patient safety culture determinants of the adverse event reporting, and the implications for Ghanaian healthcare facilities.MethodsThe study employed a multi-centre cross-sectional survey on 1651 health professionals in 13 healthcare facilities in Ghana using the Survey on Patient Safety (SOPS) Culture, Hospital Survey questionnaire. Analyses included descriptive, Spearman Rho correlation, one-way ANOVA, and a Binary logistic regression model.ResultsThe majority of health professionals had at least reported adverse events in the past 12 months across all 13 healthcare facilities. Teamwork (Mean: 4.18,SD: 0.566) and response to errors (Mean: 3.40, SD: 0.742) were the satisfactory patient safety culture. The patient safety culture dimensions were statistically significant (χ2(9, N = 1642)= 69.28,p< .001) in distinguishing between participants who frequently reported adverse events and otherwise.ConclusionPromoting an effective patient safety culture is the ultimate way to overcome the challenges of adverse event reporting, and this can effectively be dealt with by developing policies to regulate the incidence and reporting of adverse events. The quality of healthcare and patient safety can also be enhanced when healthcare managers dedicate adequate support and resources to ensure teamwork, effective communication, and blame-free culture.
Diagnostic value of fetal autopsy after early termination of pregnancy for fetal anomalies
Authors: Peyronnet Violaine , Anselem Olivia , Loeuillet Laurence , Roux Nathalie , Tsatsaris Vassilis 
Published: October 2022

BackgroundIn early terminations of pregnancy for fetal anomaly (TOPFA) without identified cytogenetic abnormality, a fetal autopsy is recommended for diagnostic purposes, to guide genetic counseling. Medical induction, which allows analysis of a complete fetus, is generally preferred over surgical vacuum aspiration. Our objective was to assess the diagnostic value of fetal autopsies in these early terminations, relative to the first-trimester ultrasound, overall and by termination method.MaterialsFor this retrospective study at the Port Royal Maternity Hospital, we identified all TOPFA performed from 11 weeks to 16 weeks diagnosed at the first-trimester ultrasound in cases with a normal karyotype. The principal endpoint was the additional value of the autopsy over /compared to the ultrasound and its impact on genetic counseling, globally and by termination method. The secondary objective was to compare the complication rate by method of termination.ResultsThe study included 79 women during period of 2013–2017: 42 with terminations by medical induction and 37 by aspiration. Fetal autopsy found additional abnormalities in 54.4% of cases, more frequently after medical induction (77.5%) than after aspiration (21.4%, p < .01). Genetic counseling was modified in 20.6% of cases, more often after induction (32.5% vs 3.6%, p < .01). The length of stay was significantly longer and a secondary aspiration was required in 16,7% of case in the medical induction group (p < .01).ConclusionMedically induced vaginal expulsion appears preferable and can change genetic counseling for subsequent pregnancies.
Determination of oil composition of cowpea (Vigna unguiculataL.) seeds under influence of organic fertilizer forms
Authors: Yürürdurmaz Cengiz 
Published: October 2022

AbstractThis research was carried out to determine the effects of different organic fertilizer forms on important quality elements of cowpea (Vigna unguiculataL.) seeds. The experiment was conducted according to the completely randomized blocks experimental design with three replications. In the experiment, palmitic acid (PALA), stearic acid (SA), and behenic acid (BA) from saturated fatty acids and palmitoleic acid (PLA), oleic acid (OA), linoleic acid (LA), and linolenic acid (LNA) ratios from unsaturated fatty acids were investigated. Besides these, quality factor such as oleic acid/linoleic acid (O/L) ratio, which is one of the oil stability values and iodine value (IV), unsaturated fatty acids/saturated fatty acids (USFA/SFA) ratio, and oil ratio and oil yield were investigated. As a result of these applications, the values of crude oil yield 27.08–40.68 kg ha−1and some important quality properties of crude oil ratios 0.75–1.09%, PLA 0.250–0.372%, OA 12.00–22.85%, LA 22.97–29.97%, LNA 19.37–26.01%, PALA 19.53–23.53%, SA 5.27–7.04%, BA 1.86–2.37%, O/L acid ratio 0.402–1.043%, IV 113.73–136.76, and USFA/SFA ratio 2.08–2.74 were obtained.
Network Insight and Entrepreneurial Performance of New Ventures: Understanding the Roles of Resource Integration and Dynamic Management Capability
Authors: Lyu Tu , Guo Yulin , Chen Hao , Lin Huan , Yu De 
Published: October 2022

Abstract
This study integrates social network theory and dynamic capability theory to explore the influence of network insight on entrepreneurial performance under the mediating role of resource integration, and the influence path of dynamic management capability. We test a series of hypotheses using survey data from 228 Chinese enterprises and applying partial least squares based structural equation modeling (PLS-SEM). Our study provides knowledge to understand new ventures’ performance promotion from a new perspective of network insight. We empirically found a mechanism between structural insight, relational insight, and environmental insight on entrepreneurial performance. Besides, this study also revealed a boundary condition of dynamic management capability to understand how organizational resource integration motivates entrepreneurial performance.
“The message is clear”: An L1 business perspective on non-target-like formulaic expressions in L2 German
Authors: Boone Griet , Ruytenbeek Nicolas , Decock Sofie 
Published: October 2022

AbstractThis study examines how non-target-like formulaic expressions used by advanced second language (L2) speakers of German are perceived by first language (L1) German business professionals in an intercultural workplace setting. By using an experimental design, we explore how L1 business professionals (N = 84) perceive the appropriateness and acceptability of the non-target-like expressions as well as how they perceive the communicative competence of the writer in two conditions: one in which the writer is explicitly described as an L2 user of German (intercultural condition), and one in which the writer is not (German condition). Moreover, by first establishing recurrent unconventionalities when L2 users create their own formulaic expressions (i.e., misspellings, grammatical errors, pragmalinguistic and sociopragmatic infelicities), we examine the effect of the type of unconventionality. Our experimental stimuli are based on authentic student responses to situations in an intercultural workplace setting which were elicited through a written discourse completion task. Our results indicate that in both conditions expressions containing a grammatical error are judged as least acceptable, followed by those with a pragmatic infelicity. Ratings were significantly higher in the intercultural condition, suggesting tolerance of the L1 professionals towards non-target-like expressions of L2 users.
Ultrasound contrast agents from microbubbles to biogenic gas vesicles
Authors: Zeng Wenlong , Yue Xiuli , Dai Zhifei 
Published: October 2022

Abstract
Microbubbles have been the earliest and most widely used ultrasound contrast agents by virtue of their unique features: such as non-toxicity, intravenous injectability, ability to cross the pulmonary capillary bed, and significant enhancement of echo signals for the duration of the examination, resulting in essential preclinical and clinical applications. The use of microbubbles functionalized with targeting ligands to bind to specific targets in the bloodstream has further enabled ultrasound molecular imaging. Nevertheless, it is very challenging to utilize targeted microbubbles for molecular imaging of extravascular targets due to their size. A series of acoustic nanomaterials have been developed for breaking free from this constraint. Especially, biogenic gas vesicles, gas-filled protein nanostructures from microorganisms, were engineered as the first biomolecular ultrasound contrast agents, opening the door for more direct visualization of cellular and molecular function by ultrasound imaging. The ordered protein shell structure and unique gas filling mechanism of biogenic gas vesicles endow them with excellent stability and attractive acoustic responses. What’s more, their genetic encodability enables them to act as acoustic reporter genes. This article reviews the upgrading progresses of ultrasound contrast agents from microbubbles to biogenic gas vesicles, and the opportunities and challenges for the commercial and clinical translation of the nascent field of biomolecular ultrasound.