bluuebunny/crossref_metadata_2025_split huggingface dataset:
Soil Erosion Evaluation through Prioritization of Shyok-Nubra Watershed using Morphometric, Principal Component and Weighted Sum Approaches
Authors: Dubey R.K . , Jha Viveka Nand 
Published: August 2022

Abstract
The application of sub-watershed prioritization based on erosion tendency plays essential roles in decision making in implementing management practices, especially in the sensitive difficult remote areas. The watershed management planning highlights the management techniques to control the erosion in the catchment area. Quantitative morphometric analysis was carried out for determining the linear, areal and relief aspect of Shyok-Nubra watershed and its 18 sub-watersheds of Ladakh Himalaya. Prioritization of the sub-watersheds has been done using Preliminary morphometric analysis, Weighted Sum Analysis (WSA) and Principal Component Analysis (PCA) methods using Arc-GIS and SPSS softwares. The use of PCA aimed to define significant parameters, while WSA was employed to determine the weights for significant parameters and calculate the compound values for priority ranking. The result showed that the integration of PCA and WSA is robust enough to define significant and more effective parameters with their weighted values for the sub-watershed prioritization.
Performance analysis of an Earth-Air Heat Exchanger applied to the ventilation of a near Zero Energy Building
Authors: Ghorbel Salmen , Bentaher Hatem , Tejero-Gonzalez Ana , Ayed Mossaad Ben , Fterich Mohamed 
Published: August 2022

Abstract
Introducing near Zero Energy Buildings (nZEBs) in the European Union involves integrating new renewable energy technologies into buildings. Geothermal energy is one of them that can be exploited through the application of the Earth-Air Heat Exchanger (EAHX). It is basically constituted of a series of pipes buried underground at a particular depth. It utilizes the soil as a heat source or sinks to supply cooling or heating to the building. This type of exchanger can offer many advantages in terms of energy savings for the air-conditioning requirements and for assuring the indoor thermal comfort. This paper presents a performance analysis of an EAHX applied to the ventilation of a near Zero Energy Building situated in Spain. The proposed considered the thermo-physical proprieties of the soil in the region under investigation. The purpose is to study the effect of changing the depth in the ground, the pipe length, the pipe diameter, and the air velocity on the outlet air temperature. The mean efficiency of the EAHX is detailed then. The numerical model is implemented using Matlab environment. Results showed that, for specific parameters, the daily average cooling capacity can reach 1.7 KWh, and the EAHX can provide an energy saving of approximately 152 MWh for one year.
First case of VIM-1-producing Leclercia adecarboxylata in Oman: A case report and literature review.
Authors: Shuhoumi Mohammed Al , Mhrooqi Abdulrahman Al , Rashdi Azza Al , Kumar Rajesh , Al-Jabri Ahood , Al-Kalbani Amal , Jardani Amina Al 
Published: August 2022

Abstract
Leclercia adecarboxylata is a recently acknowledged emerging pathogen. It is a member of the Enterobacterals family, formerly thought to be a member of the genus Escherichia. Isolation was reported from various animal and environmental specimens. However, it rarely causes infection in humans, and the true frequency is unknown or underestimated. Leclercia adecarboxylata showed an ascending resistance grade from pan-sensitive to Carbapenem-resistant due to its ability to produce and harbour hydrolyzing enzymes that challenge daily clinical practices. In our report, the isolate was misidentified as Citrobacter koseri by API E and Pantoea species by Vitek 2 but confirmed by MALDI-TOF MS and 16S ribosomal RNA analysis as Leclercia adecarboxylata. Conventional PCR revealed the presence of two populations of resistance genes, VIM-1 and OXA-48. Herein, a report of the first emergence of Leclercia adecarboxylata producing VIM-1 in a rectal swab of a 63-year-old non-immunocompromised female with acute intracerebral haemorrhage.
Comparison of different definitions of bronchopulmonary dysplasia based on the prediction of adverse outcomes: Followed up to 18-24 months corrected age
Authors: Li Ruiwen , Wang Li , Wang Jianhui , Liu Hui , Shi Yuan 
Published: August 2022

Abstract
Background
In clinical work, the BPD definition has not been clearly unified and standardized, which limits clinical progress. A BPD diagnostic screening standard that can effectively predict the prognosis, as well as standardize the clinical early diagnosis and treatment of BPD, is needed.
Methods
We conducted an ambispective cohort study to compare the effects of the three different definitions of BPD on clinical diagnosis and the predictive ability of prognosis (followed to 18–24 months corrected age).
Findings:
The diagnostic rate of BPD defined in 2001 was significantly higher than that created in 2018 or 2019 (P < 0.05), while the probability of adverse outcomes in infants with moderate and severe BPD diagnosed by the 2018 and 2019 definitions was significantly higher than those diagnosed by the 2001 definition (P < 0.05).
Interpretation:
The 2018 and 2019 diagnostic definitions are more accurate in predicting BPD-related adverse outcomes, especially respiratory outcomes. We suggest that for infants with BPD diagnosed via the 2001 definition, moderate and severe BPD should be screened again using the 2019 definition (which is easier to define than 2018), and early preventive intervention should be carried out.
Study on the relationship between urinary copper deficiency and neurological symptoms exacerbation after treatment in Wilson's disease
Authors: ZHOU Xiangxue , LIAO jian , QIN Haoling , XIAO Xia 
Published: August 2022

Abstract
Objective: To study the clinical characteristics and response to chelating agent therapy in patients of Wilson's disease (WD) with insufficient urinary copper exclusion, and to analyze the factors of insufficient urinary copper exclusion. Methods: Collect 40 WD patients with deficiency urinary copper exclusion (the highest urinary copper <500mg/L), 40 WD patients with normal urinary copper exclusion, and 10 normal control cases. The modified Young scale, Child grading, metal metabolism were checked. Magnetic sensitive imaging, dispersion tensor imaging, magnetic resonance imaging checks were performed. The values of phase value (CP), fractional anisotropy (FA), N-acetyl nmda/Creatine (NAA/Cr) were measured. According to the imaging results, WD patients were divided into clinical stages (metal deposition stage, fiber damage stage and neuron necrosis stage). All patients were treated with metal chelating agent for 3 months.Results: 26 cases were in the stage of neuronal necrosis in the group with insufficient urinary copper exclusion. After D-penicillamine (DPA) and sodium dimercaptopropansulfonate (DMPS) treatment, the modified Young scale score of group with insufficient copper exclusion was higher than that of the group with normal copper exclusion (P=0.013, 0.027). The factors influencing the deficiency of urinary copper exclusion were disease type (OR value: 1.22, P=0.031), age of onset (OR value: -0.19, P=0.041), and total score of modified Young scale (OR value: 0.14, P=0.020).Conclusion: WD patients with insufficient urinary copper exclusion have high severity of neurological symptoms. After DPA and DMPS treatment, WD patients with insufficient urinary copper exclusion are prone to worsen neurological symptoms.
BAIAP2L2 is activated by NFκB1 and promotes the malignancy of hepatocellular carcinoma by suppressing the ubiquitin-mediated degradation of GABPB1 to activate TRET transcription
Authors: Jia Wenbo , Yu Liang , Xu Bin , Feng Yanzhi , Wang Jinyi , Chu Jian , Zhu Deming , Xu Chao , Zhou Yongping , Kong Lianbao , Ding WenZhou 
Published: August 2022

Abstract
Hepatocellular carcinoma (HCC) is one of the most commonly diagnosed human cancers in the world and the fourth leading cause of cancer-related death. In this study, we found that BAI1-associated protein 2-like 2 (BAIAP2L2) was upregulated in HCC tissues and was an independent risk factor for overall survival in HCC patients. BAIAP2L2 promoted cell proliferation, stem cell activity, and cell cycle progression and inhibited apoptosis in HCC. In addition, BAIAP2L2 enhanced HCC metastasis and activated the EMT pathway. At the molecular level, NFκB1 stimulated BAIAP2L2 transcription by binding directly to its promoter region. BAIAP2L2 interacted with GABPB1 to inhibit its ubiquitin-mediated degradation and promote its nuclear translocation. Moreover, BAIAP2L2 regulated telomerase reverse transcriptase (TERT) by upregulating GABPB1 and subsequently promoted cancer properties in HCC. Collectively, our study reveals the function and mechanism of BAIAP2L2 in HCC and provides a potential biomarker and therapeutic target for HCC.
Microscale surface topography and its forming mechanism in abrasive suspension jet processing
Authors: Wang Fengchao , Li Xinwang , Xie Han , Zhao Wei 
Published: August 2022

Abstract
Microscale, nanometer to micrometer, is critical to research machining quality of abrasive suspension jet processing (ASJP), in which scale the surface topography of the processing section can be clearly shown and the material removal mechanism can be easily determined. In this paper, an experiment was carried out that three kinds of materials, Ti-6Al-4V (TC4), marble, and glass, cut by abrasive suspension jet (ASJ) and the microscale surface topography captured by an ultra-deep three-dimensional microscope. The experimental results showed that microscale surface topography of the three materials cut by ASJ is different due to their brittleness and toughness. TC4 cutting surface is covered by long and thin scratches with straight down direction, marble cutting surface is covered by pot holes, and glass cutting surface is covered by both of the scratches and pot holes. The scratches are between 40 and 140 microns in length, while the pot holes are between 10 and 40 microns in width. Moreover, forming mechanism of the three materials’ microscale surface topography is also different due to their brittleness and toughness. The scratch on TC4 cutting surface is the plastic damage caused by the abrasive particles, and the pot hole is the brittle fracture caused by the abrasive particles. Intermediate between brittle and plastic materials, glass cut by ASJ with both plastic damage and brittle fracture. The conclusions can provide theory guidance in material precision processing with ASJ.
Nonlinear dynamic analysis of asymmetric bistable energy harvesters
Authors: Norenberg João Pedro , Luo Roberto , Lopes Vinicius Gonçalves , Peterson João Victor , Cunha Americo 
Published: August 2022

Abstract
Nonlinear vibration energy harvesting systems can potentially increase the power collected from the kinetic energy available in their operating environment since they usually can recover energy in broadband frequencies compared to their linear counterpart. However, these systems have a high degree of complexity, sensitivity to slight variations of the parameters and the initial conditions, and may present multiple solutions. For these reasons, it is rare for the designer to have a deep understanding of the dynamic behavior of this type of nonlinear oscillator. This situation is even more peculiar when geometric imperfections from the system's manufacturing process are present, as they can significantly influence the energy recovery process. Intending to fill this lack of understanding about general aspects of the nonlinear dynamics of these kind of systems, the present paper presents a broad numerical investigation of local and global characteristics of the underlying dynamical systems using bifurcation diagrams and basins of attraction. Bifurcation analysis is performed by exploring the broad spectrum of a harmonic signal, going from low to high amplitude and frequency of excitation. Basins of attraction analysis based on 0-1 test for chaos is proposed as an efficient statistical technique to identify chaotic and periodic solutions. Different levels of asymmetry are investigated, and a particular situation is defined and analyzed when a value of the sloping angle where the system is attached compensates for the asymmetry of the quadratic term. The result shows the different solutions defined by excitation forces and initial conditions, indicating the best scenario for increasing the power output. The adverse effects of the asymmetries are presented. However, we also demonstrated that it is possible to around this behavior using the sloping angle to compensate for the asymmetric influence, obtaining good performance as a symmetric system.
Two Algorithms for Deciding Coincidence In Double Temporal Recurrence of Eventuality Sequences
Authors: Akinkunmi Babatunde Opeoluwa , Adegbola Adesoji A. 
Published: August 2022

Abstract
Two disjoint sequences of eventualities x and y both recur over the same time interval and each of the eventualities (xp from x say) have a fixed duration when they occur and it is required to determine whether or not a subinterval exists within the interval of double recurrence, for any intervals of occurrence of eventualities xp from x and yq from y. This paper presents two algorithms for solving the problem. One based on the existing idea of temporal projection over a cycle of double recurrence with a worst case running time of Ο(duration(x)*duration(y)) and the other based on the notion of gcd-partitions runs in linear time, i.e. Ο(max(duration(x), duration(y)). The gcd-partition of a double recurrence of a pair of eventuality sequence of (x, y) is another eventuality sequence pair (w, z) such that each a double recurrence of the pair (x, y) holds exactly when the double recurrence of (w, z) also holds, the duration of each eventuality in w and z is the greatest common divisor of the durations of x and y. A key property of gcd partitions is that for any wr and zs in w and z respectively, an interval exists within any cycle of the recurrence of x and y, over which both wr and zs occur. The algorithm then explores the eventualities from w that are naturally non-disjoint with xp and those from z that are naturally non-disjoint with yq in order to determine the coincidence of xp and yq.
Effects of age, testicular volume, reproductive hormone, and testicular biopsy on sperm retrieval rate of micro-TESE in NOA patients with AZFc deletion
Authors: Deng Chenyao , Mao Jiaming , Zhao Lianming , Liu Defeng , Lin Haocheng , Zhang Zhe , Yang Yuzhuo , Zhang Haitao , Hong Kai , Jiang Hui 
Published: August 2022

Abstract
Objective: To investigate whether age, testicular volume, reproductive hormone, and preoperative diagnostic testicular biopsy affected sperm retrieval rate (SRR) in individuals with non-obstructive azoospermia (NOA).Patients and methods: Retrospective analysis of clinical data of NOA patients with AZFc deletion who had microdissection testicular sperm extraction (micro-TESE). The effects of age, testicular volume, FSH, LH, T, and preoperative diagnostic testicular biopsy on SRR were compared cross-sectionally in this group of patients.Results: A total of 181 individuals had their sperm successfully collected and underwent micro-TESE, with an SRR of 67.4 %. The results of micro-TESE were separated into two groups: sperm acquisition and non-sperm acquisition, with no significant variations in age, testicular volume, FSH, LH, and T between the two groups. Binary logistic regression explored the absence of significant effects of age, testicular volume, FSH, LH, and T on sperm acquisition in patients undergoing micro-TESE. Based on whether or not a preoperative diagnostic testicular biopsy was conducted, the above parameters were compared between the two groups. Testicular volume was higher in the group with preoperative diagnostic testicular biopsy than in the group without preoperative diagnostic testicular biopsy, while FSH and T were lower. In the preoperative testicular diagnostic biopsy group, the sperm acquisition and non-acquired sperm groups had SRR of 90.1 % and 65.1 %, respectively, with the sperm acquisition group being significantly higher than the non-acquired sperm group.Conclusion: There is a high probability of successful sperm acquisition in the testis with micro-TESE. In this group of patients, age, testicular volume, FSH, LH, and T may have little bearing on the micro-TESE outcome. In patients whose preoperative diagnostic testicular biopsy revealed no sperm, the probability of obtaining sperm by micro-TESE remained high (65.1%), while negative preoperative diagnostic testicular biopsy results appeared to not influence SRR by micro-TESE.
hBMSC-derived Exosomes Mitigate Th17/Treg Homeostasis in Periodontitis via miR-1246
Authors: Xia Yuxing , Cheng Tianfan , Zhou Min , Kang Feiwu , Liao Chongshan 
Published: August 2022

Abstract
Background
Chronic inflammatory bone loss in periodontitis is closely related to helper T cell 17 (Th17) / regulatory T cell (Treg) imbalance. The therapeutic function of mesenchymal stem cells is mainly attributed to the paracrine exosomes. We aimed to investigate the immunomodulatory effect of human bone marrow mesenchymal stem cells (hBMSC)-derived exosomes in Th17/Treg homeostasis in periodontitis.
Methods
Peripheral blood was collected from periodontitis patients or healthy donors. The level of Th17-related biomarker interleukin-17A (IL-17A) and Treg-related forkhead box protein 3 (FOXP3) was analyzed by ELISA, and mRNA expression level of RAR-related orphan receptor C (RORC) and FOXP3 was detected by qRT-PCR. Naïve CD4+ T cells extracted from the peripheral blood of periodontitis patients were co-cultured with hBMSC-derived exosomes from healthy subjects. The ratio of Th17/Treg was examined by flow cytometry and the expression of inflammatory cytokines was determined by qRT-PCR. In vivo, exosomes-loaded hydrogel was injected into periodontal pockets of mice with experimental periodontitis. The periodontal inflammation and bone regeneration was evaluated by histological staining, immunofluorescence staining and micro-CT. Furthermore, the differentially expressed miRNAs in exosomes stimulated by P.g. LPS were investigated by miRNA sequencing and bioinformatics analysis. The interaction between candidate miRNA and its target gene in CD4+ T cells was verified by dual luciferase activity assay. Lastly, the downstream Yes-related protein 1(YAP1)/Hippo pathway was evaluated by western blotting.
Results
The ratio of Th17/Treg is significantly increased in the peripheral blood of periodontitis patients. hBMSC-derived exosomes decreased Th17/Treg ratio in CD4+ T cells in vitro and ameliorated inflammation and bone loss in periodontitis mice. Mechanistically, the enrichment of miR-1246 in exosomes showed the enhanced effects of down-regulating Th17/Treg ratio, which could be reversed by miR-1246 inhibitor. Furthermore, exosomal miR-1246 suppressed the expression of the target protein angiotensin converting enzyme2 (ACE2) and upregulated the expression ratio P-YAP1/YAP1 in CD4+ T cells.
Conclusions
hBMSC-derived exosomes could alleviate periodontal inflammation through modulating the balance of Th17/Treg via targeting ACE2 and downregulating YAP1/Hippo signaling pathway, which shed light on a novel cell-free immunotherapy for periodontal regeneration.
Temporal and spatial distribution trends of polio vaccine coverage in children in Brazil, 2011-2021
Authors: SILVA TÉRCIA MOREIRA RIBEIRO DA , de Sá Ana Carolina Micheletti Gomide Nogueira , Prates Elton Junio Sady , Saldanha Raphael de Freitas , Silva Thales Philipe Rodrigues da , Teixeira Antônia Maria , Beinner Mark Anthony , de Oliveira Suelen Rosa , de Sá Antonio Tolentino Nogueira , Matozinhos Fernanda Penido , Vieira Ed Wilson Rodrigues 
Published: August 2022

Abstract
Background: Low polio vaccine coverage can result in the spread of Poliovirus to areas free from viral circulation. This study analyzed the temporal trends and spatial distribution of polio vaccine coverage for children under five years of age in Brazil, between 2011 and 2021. Methods: This is an ecological, time-series study (2011 to 2021) with annual vaccine coverages against poliomyelitis, extracted from the Information System of the National Immunization Program from regions of the 27 Brazilian states. The percentage reductions in vaccination coverage in Brazil and in the Regions were calculated. Prais-Winsten regression models were used to analyze time series for the Regions and States, and spatial analysis identified the distribution of clusters (high-high; low-low; high-low and low-high) of vaccination coverages across Brazilian municipalities, using a 5% significance level. Results: From 2011 to 2021, the coverage of polio vaccines decreased by 46.1%. There was a progressive increase observed in clusters resulting in low vaccination coverages (136 low-low Brazilian municipalities in 2011 vs 614 in 2021), mostly reported in the North and Northeast regions of the country. There was a downward trend in vaccination coverages in 8 of the 27 States (p ≤ 0.05). Conclusions: The reduction in polio vaccine coverage, as observed in the North and Northeast regions of Brazil, may favor the spread of Poliovirus. Therefore, vaccination strategies should be prioritized for children residing in areas with sharp and recurrent declines in vaccination coverages, including travelers, migrants and refugees.
Realizing stochastic fixed-time synchronization between two nonlinear chaotic finance systems
Authors: Wu Jie , Pan Xiaohong , Hu Lei , Wu Kexing , Wang Xiaofeng 
Published: August 2022

Abstract
The issue of stochastic fixed-time synchronization(SFxS) between two nonlinear chaotic finance systems(CFSs) in noisy environment is addressed by this investigation. Two novel strategies, including the adaptive and fixed-time control, are integrated organically, which steers the CFSs to realize synchronization within a fixed-time, and meanwhile the controlling gains can be updated by the designed adaptive law. Particularly, the designed adaptive fixed-time controlling(AFC) scheme is differentiable, so that the chattering phenomenon can be alleviated and even eliminated effectively. Furthermore, by the stochastic Lyapunov stability, the sufficient criterion is derived for realizing the SFxS of CFSs, and the upper-bound expectation of settling-time(UET) is estimated as well. At last, the numerical experiments are arranged to verify the correctness and feasibility of analytical results, and the influence of noisy perturbation on the convergence rate is uncovered.
The Netherlands may lose up to 40% of its plant species due to climate change
Authors: Wamelink G. W. Wieger , Kurvers Katrien 
Published: August 2022

Abstract
The increasing CO2 in the Earth’s atmosphere is directly increasing global temperatures. Plant species around the world must directly and indirectly respond to this temperature change, either by adapting, migrating, or perishing. To evaluate the effect of temperature rises on European plant species, we combined vegetation data with the local average temperature to estimate the temperature range per species. Subsequently, for every 1°C increase in average temperature, we determined the species currently occurring in the Netherlands for which the expected temperature is outside its range, but also the species currently absent from the country for which the expected temperature has moved within its range. We show that up to 40% (427 out of 1239) of the species currently occurring in the Netherlands may become locally extinct if the average annual temperature rises from 9°C in 1950 to 14°C in 2085. We also show that over 1000 species potentially could arrive as climate refugees; however, it is questionable whether these species could reach the Netherlands due to limitations in dispersal capacity. Moreover, these species will have to adapt to the pre-existing ecosystems. Results have major implication for both nature policy as well as nature management.