bluuebunny/crossref_metadata_2025_split huggingface dataset:
A quantitative assessment of the VO line list: Inaccuracies hamper high-resolution VO detections in exoplanet atmospheres
Authors: de Regt S. , Kesseli A. Y. , Snellen I. A. G. , Merritt S. R. , Chubb K. L. 
Published: February 2022

Context.Metal hydrides and oxides are important species in hot-Jupiters since they can affect their energy budgets and the thermal structure of their atmospheres. One such species is vanadium-oxide (VO), which is prominent in stellar M-dwarf spectra. Evidence for VO has been found in the low-resolution transmission spectrum of WASP-121b, but this has not been confirmed at high resolution. It has been suggested that this is due to inaccuracies in its line list.Aims.In this paper, we quantitatively evaluate the VO line list and assess whether inaccuracies are indeed the reason for the non-detections at high resolution in WASP-121b. Furthermore, we investigate whether the detectability can be improved by selecting only those lines associated with the most accurate quantum transitions.Methods.A cross-correlation analysis was applied to archival High Accuracy Radial velocity Planet Searcher and CARMENES spectra of several M-dwarfs. VO cross-correlation signals from the spectra were compared with those in which synthetic VO models were injected, providing an estimate of the ratio between the potential strength (in case of a perfect model) and the observed strength of the signal. This was repeated for the reduced model covering the most accurate quantum transitions. The findings were subsequently fed into injection and recovery tests of VO in a Ultraviolet and Visual Echelle Spectrograph transmission spectrum of WASP-121b.Results.We find that inaccuracies cause cross-correlation signals from VO in M-dwarf spectra to be suppressed by about a factor 2.1 and 1.1 for the complete and reduced line lists, respectively, corresponding to a reduced observing efficiency of a factor 4.3 and 1.2. The reduced line list outperforms the complete line list in recovering the actual VO signal in the M-dwarf spectra by about a factor of 1.8. Neither line list results in a VO detection in WASP-121b. Injection tests show that with the reduced efficiency of the line lists, the potential signal as seen at low resolution is not detectable in these data.
Hausärztliche Einschätzungen zur Verbesserung der Palliativversorgung an der Schnittstelle zur spezialisierten ambulanten Palliativversorgung (SAPV)
Authors: Stichling Kathleen , Bleidorn Jutta , Krause Markus , Meißner Winfried , Wedding Ulrich , Bauer Anna , Krauss Sabine H. , Schneider Werner , Jansky Maximiliane , Nauck Friedemann , Vollmar Horst Christian , Schulz Sven , Freytag Antje 
Published: February 2022

Zusammenfassung
Ziel der Studie Erhebung von Perspektiven palliativversorgender Hausärzte (HÄ)1 an der Schnittstelle zur SAPV und Verbesserungsvorschläge.
Methodik Querschnittliche Befragung von HÄ aus acht Kassenärztlichen Vereinigungen (KV). Quantitative Analyse von 1144 Fragebögen zu Verbesserungsvorschlägen und qualitative Analyse von 187 Freitextkommentaren.
Ergebnisse Eine bessere Qualifikation ambulanter Pflegedienste wurde am häufigsten (91,7 %) als wichtige Rahmenbedingung für die hausärztliche Palliativversorgung (PV) genannt. Die 187 Freitextkommentare adressierten vielschichtige Dimensionen hausärztlich erlebter PV: HÄ betonen ihre zentrale Rolle; die Beurteilung der SAPV-Einbindung variiert von Ressource bis zur hausärztlichen Ausgrenzung aus der Versorgung und Kompetenzabschreibung.
Schlussfolgerung Geäußerte Lösungsansätze für empfundene Defizite sollten Gehör finden, wenn sie zu einer effizienten Deckung des PV-Bedarfs beitragen: bessere Qualifizierung der Pflegedienste; Vermeidung von Ausgrenzung von HÄ aus der Versorgung bei SAPV-Einbindung; bessere Vernetzung aller Akteure.
Die seltenen Histiozytosen (Non-Langerhans-Zell-Histiozytosen)
Authors: Classen Carl Friedrich 
Published: February 2022

ZUSAMMENFASSUNGSeltene Histiozytosen, auch Non-Langerhans-Zell-Histiozytosen, sind alle proliferativen Erkrankungen der Histiozyten außer den Langerhans-Zell-Histiozytosen (LCH) und Hämophagozytischen Lymphohistiozytosen (HLH): benigne oder maligne, lokalisierte oder systemische, adulte oder pädiatrische Erkrankungen. Eine 2016 publizierte Klassifikation definiert Subgruppen als L-Gruppe (LCH-ähnlich, hierzu die Erdheim-Chester-Erkrankung, ECD), C-Gruppe (kutan/mukokutan, u. a. die Xanthogranulomatosen, XG), M-Gruppe (maligne Histiozytosen, MH), R-Gruppe (Rosai-Dorfman-Erkrankung, RDD, ähnlich) und H-Gruppe (HLH-ähnlich). In der Pädiatrie am häufigsten sind XG und RDD. Manche haben eine exzellente Prognose (v. a. C-Gruppe und RDD, mit Ausnahmen), andere sind rasch fatal (v. a. MH). So reicht die Therapie von wait-and-see bis zu intensiver Chemotherapie. Zunehmend werden klonale Veränderungen, v. a. im RAS/RAF- bzw. MAPK-Signalweg, identifiziert, mit der Möglichkeit von „targeted“ Therapien. Erfahrungen sind aber noch kaum publiziert, was die systematische Erfassung – in Deutschland im Register Seltene Histiozytosen als Teil des International Rare Histocytic Disorder Registry (Toronto) – nötig macht.
Pyruvatkinasemangel der Erythrozyten
Authors: Klothaki Paraskevi , Kollmar Nina , Nathrath Michaela 
Published: February 2022

ZUSAMMENFASSUNGDie kongenitalen hämolytischen Anämien sind seltene Störungen der Hämatopoese und stellen eine diagnostische und therapeutische Herausforderung für den Allgemeinpädiater und den Neonatologen dar. Zur Differenzialdiagnose gehören die Enzymdefekte der Erythrozyten. Diese betreffen einen der drei Stoffwechselwege der Erythrozyten: den Embden-Meyerhof-Weg (Glykolyse), den Pentosephosphatweg oder den Nukleotidstoffwechsel. Der häufigste Enzymdefekt der Glykolyse ist der Pyruvatkinasemangel (PK-Mangel). Es handelt sich dabei um eine seltene hereditäre nicht sphärozytäre hämolytische Anämie. Die Prävalenz des diagnostizierten PK-Mangels wird zwischen 3,2 und 8,5 pro Million Einwohner geschätzt 14. Vermutlich ist die Prävalenz aufgrund der vielen nicht diagnostizierten Fällen deutlich höher 14. Im Rahmen dieses Beitrags wird ein diagnostischer Algorithmus präsentiert, der als Leitfaden für den Allgemeinpädiater und den Neonatologen dienen soll.
Immediate Postpartum Copper IUD: A Comparative Analysis between Profiles of Women who Accept and who Refuse it
Authors: Ferreira Paula Batista , Utiyama Raul Yao , Tamanaha Sonia , Fukunaga Erika Tiemi 
Published: February 2022

Abstract
Objective To analyze the profiles of women who accepted and who refused the insertion of the copper intrauterine device (IUD) postpartum and to learn the motivations related to the refusal of the method.
Methods Cross-sectional study with 299 pregnant women. The women were informed about the possibility of inserting a copper IUD postpartum and were questioned about their interest in adopting or not this contraceptive. All participants answered a questionnaire with information relevant to the proposals of the present study. The sample size was limited to the number of devices available for the present study.
Results A total of 560 women were invited to join the present study and 299 accepted. Out of the 299 women included in the present study, 175 accepted the copper IUD and 124 refused. As the number of pregnancies increased, the IUD acceptance rate raised (p = 0.002), especially between the groups with 1 and with ≥ 4 pregnancies (p = 0.013). Regarding the desire to have more children, the women who planned to have more children were more likely to refuse the method than the ones who did not (p < 0,001).
Conclusion Women with multiple pregnancies and desire to not have more children were more likely to accept the copper IUD. The profile of those who refused was first pregnancy and desire to have more children. Among the three most frequent reasons reported for copper IUD rejection, two responses stood out: no specific justification and desire to have more children.
Prevalence of Premenstrual Syndrome and Associated Factors Among Academics of a University in Midwest Brazil
Authors: Rezende Ana Paula Rodrigues , Alvarenga Fernanda Rassi , Ramos Marcelo , Franken Débora Luiza , Dias da Costa Juvenal Soares , Pattussi Marcos Pascoal , Paniz Vera Maria Vieira 
Published: February 2022

Abstract
Objective To investigate the prevalence of premenstrual syndrome (PMS) and premenstrual dysphoric disorder (PMDD) in university students, the factors associated with PMS, the most prevalent symptoms, and the interference of symptoms in academic, family, social, and work activities.
Methods This cross-sectional study included 1,115 university students aged ≥ 18 years from the University of Rio Verde, Goiás. Premenstrual syndrome and PMDD were identified using the Premenstrual Symptoms Screening Tool. Associations with sociodemographic, behavioral, reproductive, nutritional, and health factors were investigated using the Poisson regression.
Results The prevalence of PMS was 46.9% (95% confidence interval [CI] 44.0–49.8), and of PMDD, 11.1% (95% CI 9.3–13.0). The most prevalent symptoms were physical, such as breast tenderness, bloating, e weight gain (73%); followed by psychological ones such as overeating/food cravings, tearful/more sensitive to rejection (> 60%). More than 30% of the patients reported that the symptoms interfered in a moderate-to-severe way in their social and academic activities. After adjusted analysis, PMS was more prevalent in those who were attending the 1st/2nd semester of college (prevalence ratio [PR] 1.44; 95% CI 1.14–1.80), those who consumed alcohol in the last 30 days (PR 1.23; 95% CI 1.04–1.47), and those who had depression (PR 1.49; 95% CI 1.30–1.71).
Conclusion Almost half of the university students had PMS and ∼ 11%, PMDD. Physical symptoms were the most common and interfered in a moderate-to-severe way in various aspects of life. Attending the first semesters, consuming alcohol, and having depression were risk factors for PMS. The identification of risk factors for PMS is essential to prevent symptoms and reduce the impact of the syndrome.
Habits of Genital Hygiene and Sexual Activity among Women with Bacterial Vaginosis and/or Vulvovaginal Candidiasis
Authors: Bardin Marcela Grigol , Giraldo Paulo César , Benetti-Pinto Cristina Laguna , Sanches José Marcos , Araujo Camila Carvalho de , Amaral Rose Luce Gomes do 
Published: February 2022

Abstract
Objective To evaluate genital hygiene among women with and without bacterial vaginosis (BV) and/or vulvovaginal candidiasis (VVC).
Methods A cross-sectional study of reproductive-aged women who underwent gynecological and laboratory tests and fulfilled a genital hygiene questionnaire.
Results This study evaluated 166 healthy controls and 141 women diagnosed with either BV (n = 72), VVC (n = 61), or both (n = 8). The use of intimate soap and moist wipes after urination was more frequent among healthy women (p = 0.042 and 0.032, respectively). Compared to controls, bactericidal soap was more used by women with BV (p = 0.05).
Conclusion Some hygiene habits were associated to BV and/or VVC. Clinical trials should address this important issue in women's health.
Colposcopic Findings and Diagnosis in Low-Income Brazilian Women with ASC-H pap Smear Results
Authors: Maffini Cibele Feroldi , Collaço Luiz Martins , Sebastião Ana Paula Martins , Zanine Rita Maira 
Published: February 2022

Abstract
Objective To determine the accuracy of colposcopy findings in diagnosing cervical intraepithelial neoplasia (CIN) in women with an atypical squamous cells, cannot exclude high-grade squamous intraepithelial lesion (ASC-H) pap smear result and analyze whether the prevalence of HSIL and cancer correlates with sociodemographic risk factors and specific colposcopic findings.
Methods Colposcopic findings and sociodemographic risk factors were analyzed as possible predictors of a CIN 2 or worse diagnosis in women with an ASC-H pap smear result.
Results Accuracy of the colposcopic impression was 92%, sensitivity was 91.6%, and specificity was 93.1%, with a positive predictive value of 96.4% and negative predictive value of 84.3%. Diagnosis of CIN 2 or worse was more frequent in patients with a previous history of cervical dysplasia and pre-menopausal patients. Identification of major colposcopic findings, dense acetowhite epithelium, coarse mosaicism, and punctuation correlated significantly with CIN 2 or worse.
Conclusion Colposcopy performed by an experienced examiner can accurately differentiate patients with CIN 1 or less from patients with CIN 2 or worse. Diagnosis of CIN 2 or worse was more frequent in patients with a previous history of cervical dysplasia and pre-menopausal patients. The degree of acetowhite changes was the best colposcopic feature to predict CIN2 or worse.
Transcutaneous Nerve Electrostimulation (TENS) in Pain Relief During Labor: A Scope Review
Authors: Reis Carla Cristina Silveira dos , Dias Leandro da Cunha , Carvalho Lorena Bezerra , Junior Lourivaldo Bispo Alves , Imoto Aline Mizusaki 
Published: February 2022

Abstract
Objective To map health evidence on the effectiveness of transcutaneous nerve electrostimulation (TENS) therapy in pain relief during delivery.
Methods This is a scoping review in the PubMed, LILACS, Cochrane, VHL, PEDRO, and SciELO databases, through the descriptors electric stimulation, transcutaneous and labor, obstetric and their synonyms.
Results A total of 263 studies were identified, of which 54 duplicates were excluded. After sorting by titles and abstracts, there were 24 articles for reading, remaining 6. The six studies evaluated the reduction of pain through the visual analogue scale (VAS).
Conclusion The findings indicate that the use of TENS as a nonpharmacological strategy for pain relief in labor has positive results.
Effects of the COVID-19 Pandemic on Gynecological Health: An Integrative Review
Authors: Marquini Gisele Vissoci , Martins Sérgio Brasileiro , Oliveira Letícia Maria , Dias Márcia Maria , Takano Claudia Cristina , Sartori Marair Gracio Ferreira 
Published: February 2022

Abstract
Objective To analyze the existing scientific literature to find out if the coronavirus disease 2019 (COVID-19) pandemic has an effect on gynecological health.
Search Strategy We performed an integrative review of articles published between April 2020 and April 2021 on the PubMed, SciELO, and LILACS databases, using COVID-19 and the following relevant terms: Menstrual change; Ovarian function; Violence against women; Contraception; HPV; Mental health; and Urogynecology.
Selection Criteria Among the eligible studies found, editorials and primary research articles, which describe the dynamics between severe acute respiratory syndrome coronavirus (SARS-CoV-2) infection (the cause of the COVID-19 pandemic) and gynecological health, were included.
Data Collection and Analysis Through qualitative synthesis, data were extracted from the included publications and from guidelines of national and international societies of gynecology.
Main Results The 34 publications included in the present study showed that some factors of the SARS-CoV-2 infection, and, consequently, the COVID-19 pandemic, might be associated with menstrual abnormalities, effects on contraception, alterations in steroid hormones, changes in urogynecological care, effects on women's mental health, and negative impact on violence against women.
Conclusion The COVID-19 pandemic has significantly impacted the health of women. The scientific community encourages the development of recommendations for specialized care for women and strategies to prevent and respond to violence during and after the COVID-19 pandemic.
Gallbladder Neuroendocrine Carcinoma: A Case Report with Radiological–Pathological Correlation
Authors: Chandel Karamvir , Lal Anupam , Srinivas Rohit K. , Chatterjee Debajyoti , Gupta Vikas 
Published: February 2022

AbstractNeuroendocrine tumors (NET) of the biliary system, specifically the gallbladder (GB), are extremely rare, accounting for only 0.2% of all NETs. The majority of GBNETs are discovered by chance during a histological examination of GB samples at autopsy, after cholecystectomy, or after surgery for other suspected biliary pathology. GBNETs are thought to develop from preexisting endocrine cells in the GB's neck or from induced endocrine cells caused by intestinal metaplasia of the body and fundus. We present a case of squamous cell carcinoma of the GB with neuroendocrine differentiation due to its rarity.
Salvage Nipple-sparing Mastectomy for Patients with Breast Cancer Recurrence: A Case Series of Brazilian Patients
Authors: Frasson Antônio Luiz , Lichtenfels Martina , Barbosa Fernanda , Souza Alessandra Borba Anton de , Falcone Ana Beatriz , Miranda Isabela , Vollbrecht Betina , Malhone Carolina , Tariki José Yoshikazu 
Published: February 2022

Abstract
Objective Few studies analyzed the safety of salvage nipple-sparing mastectomy (NSM) for local relapse treatment. We evaluated the outcomes of patients with indications for mastectomy who chose to undergo NSM for ipsilateral breast tumor recurrence (IBTR).
Methods Between January 2001 and December 2018, we evaluated 24 women who underwent NSM for local relapse after conservative surgery.
Results The patients were followed up for a mean time of 132 months since the first surgery. After the NSM, 5 (20.8%) patients were diagnosed with local recurrence and only 1 (4.2%) patient died. The patients presented 4.8% (2) of partial and 2.4% (1) of total nipple necrosis.
Conclusion In this long-term follow-up since the first surgery, we observed low rates of complication and good survival, although associated with high local recurrence in patients diagnosed with IBTR undergoing NSM as salvage surgery. We demonstrated that NSM may be considered after IBTR for patients who did not want to undergo total mastectomy.
ERK signaling dissolves ERF repression condensates in living embryos
Authors: Weaver Claire J. , Patel Aleena L. , Shvartsman Stanislav Y. , Levine Michael S. , Treen Nicholas 
Published: February 2022

Significance
Transcriptional repression is essential for correct gene expression, and failure to repress genes appropriately is associated with many diseases. Recently, evidence is accumulating that phase separation is an important component of transcriptional repression. We show that the extracellular signal-regulated kinase (ERK) signal responsive repressor, Ets-2 repressive factor (ERF) is capable of forming condensates and that phosphorylation of ERF causes these condensates to dissolve. This provides a mechanism for how signal-dependent derepression can occur, and similar processes are likely to occur in other signaling pathways. Additionally, we document the dynamic dissolution and reformation of condensates during a single interphase in coordination with the export/import of ERF. This demonstrates an example of how nuclear condensates can function.
Fast and realistic 3D feature profile simulation platform for plasma etching process
Authors: Yook Yeong Geun , You Hae Sung , Park Jae Hyeong , Chang Won Seok , Kwon Deuk Chul , Yoon Jung Sik , Yoon Kook Hyun , Shin Sung Sik , Yu Dong Hun , Im Yeon Ho 
Published: February 2022

Abstract
We present a topographic simulation platform that simultaneously considers 3D surface movement, neutral and ion transport, and surface reactions in plasma high-aspect-ratio (HAR) oxide etching. The hash map data structure is considered for an effective 3D level-set algorithm with parallelized computations to calculate surface moving speed. Neutral and ion transport within nanoscale semiconductor geometry is parallelized with a graphics processing unit (GPU) so that the speedup ratio, as compared to a single central processing unit (CPU), is approximately 200. The surface reaction based on a two-layer model was incorporated into a 3D feature profile simulation platform with CPU parallelization. Finally, our simulation platform demonstrates that adaptive surface meshing can drastically decrease the computational load with a parallelized numerical platform.
A hybrid column generation and simulated annealing algorithm for direct aperture optimization
Authors: Mueller S , Guyer G , Risse T , Tessarini S , Aebersold D M , Stampanoni M F M , Fix M K , Manser P 
Published: February 2022

Abstract
The purpose of this work was to develop a hybrid column generation (CG) and simulated annealing (SA) algorithm for direct aperture optimization (H-DAO) and to show its effectiveness in generating high quality treatment plans for intensity modulated radiation therapy (IMRT) and mixed photon-electron beam radiotherapy (MBRT). The H-DAO overcomes limitations of the CG-DAO with two features improving aperture selection (branch-feature) and enabling aperture shape changes during optimization (SA-feature). The H-DAO algorithm iteratively adds apertures to the plan. At each iteration, a branch is created for each field provided. First, each branch determines the most promising aperture of its assigned field and adds it to a copy of the current apertures. Afterwards, the apertures of each branch undergo an MU-weight optimization followed by an SA-based simultaneous shape and MU-weight optimization and a second MU-weight optimization. The next H-DAO iteration continues the branch with the lowest objective function value. IMRT and MBRT treatment plans for an academic, a brain and a head and neck case generated using the CG-DAO and H-DAO were compared. For every investigated case and both IMRT and MBRT, the H-DAO leads to a faster convergence of the objective function value with number of apertures compared to the CG-DAO. In particular, the H-DAO needs about half the apertures to reach the same objective function value as the CG-DAO. The average aperture areas are 27% smaller for H-DAO than for CG-DAO leading to a slightly larger discrepancy between optimized and final dose. However, a dosimetric benefit remains. The H-DAO was successfully developed and applied to IMRT and MBRT. The faster convergence with number of apertures of the H-DAO compared to the CG-DAO allows to select a better compromise between plan quality and number of apertures.
Probing new physics at future tau neutrino telescopes
Authors: Huang Guo-Yuan , Jana Sudip , Lindner Manfred , Rodejohann Werner 
Published: February 2022

Abstract
We systematically investigate new physics scenarios that can modify the interactions between neutrinos and matter at upcoming tau neutrino telescopes, which will test neutrino-proton collisions with energies ≳ 45 TeV, and can provide unique insights to the elusive tau neutrino. At such high energy scales, the impact of parton distribution functions of second and third generations of quarks (usually suppressed) can be comparable to the contribution of first generation with small momentum fraction, hence making tau neutrino telescopes an excellent facility to probe new physics associated with second and third families. Among an inclusive set of particle physics models, we identify new physics scenarios at tree level that can give competitive contributions to the neutrino cross sections while staying within laboratory constraints: charged/neutral Higgs and leptoquarks. Our analysis is close to the actual experimental configurations of the telescopes, and we perform a χ2-analysis on the energy and angular distributions of the tau events. By numerically solving the propagation equations of neutrino and tau fluxes in matter, we obtain the sensitivities of representative upcoming tau neutrino telescopes, GRAND, POEMMA and Trinity, to the charged Higgs and leptoquark models. While each of the experiments can achieve a sensitivity better than the current collider reaches for certain models, their combination is remarkably complementary in probing the new physics. In particular, the new physics will affect the energy and angular distributions in different ways at those telescopes.