bluuebunny/crossref_metadata_2025_split huggingface dataset:
Central diabetes insipidus and partial anterior pituitary dysfunction in acute myeloid leukemia
Authors: Arya Rigya , Ahmad Tehmina , Dash Satya 
Published: July 2022

Summary
Central diabetes insipidus (CDI) is a rare manifestation of acute myeloid leukemia (AML) with unclear etiology. When present, CDI in AML has most often been described in patients with chromosome 3 or 7 aberrations and no abnormalities on brain imaging. In this case, we present a woman with newly diagnosed AML t(12;14)(p12;q13) found to have diabetes insipidus (DI) with partial anterior pituitary dysfunction and abnormal brain imaging. While in hospital, the patient developed an elevated serum sodium of 151 mmol/L with a serum osmolality of 323 mmol/kg and urine osmolality of 154 mmol/kg. On history, she reported polyuria and polydipsia for 5 months preceding hospitalization. Based on her clinical symptoms and biochemistry, she was diagnosed with DI and treated using intravenous desmopressin with good effect; sodium improved to 144 mmol/L with a serum osmolality of 302 mmol/kg and urine osmolality of 501 mmol/kg. An MRI of the brain done for the assessment of neurologic involvement revealed symmetric high-T2 signal within the hypothalamus extending into the mamillary bodies bilaterally, a partially empty sella, and loss of the pituitary bright spot. A pituitary panel was completed which suggested partial anterior pituitary dysfunction. The patient’s robust improvement with low-dose desmopressin therapy along with her imaging findings indicated a central rather than nephrogenic cause for her DI. Given the time course of her presentation with respect to her AML diagnosis, MRI findings, and investigations excluding other causes, her CDI and partial anterior pituitary dysfunction were suspected to be secondary to hypothalamic leukemic infiltration.

Learning points

Leukemic infiltration of the pituitary gland is a rare cause of central diabetes insipidus (CDI) in patients with acute myeloid leukemia (AML).

Patients with AML and CDI may compensate for polyuria and prevent hypernatremia with increased water intake.

AML-associated CDI can require long-term desmopressin treatment, independent of AML response to treatment.
Tomar la casa: Politics of haunting, contra-archivo y resistencia indígena en La llorona, de Jayro Bustamante
Authors: Cabello del Moral Pedro 
Published: July 2022

El largometraje La llorona (Jayro Bustamante, 2019) persigue contribuir a la restitución de una deuda histórica con el pueblo indígena guatemalteco; una deuda no satisfecha plenamente con los acuerdos de paz de 1996. El pasado espectral viene encarnado en Alma, la sirvienta maya kaqchikel que entra a trabajar en la casa del general Monteverde, responsable del genocidio de las comunidades indígenas cuando era presidente del país centroamericano. Al invertir la idea del haunting, o tormento, son el torturador y su familia lxs que se ven acosados por sus acciones pasadas, que hasta ahora habían quedado impunes, no solo a nivel jurídico, sino también a nivel moral. La figura metafórica de “La Llorona”, que llora desconsolada más allá de la muerte porque sus hijos han sido asesinados frente a ella, desencadena el terror que vivirá la familia protagonista, obligada a enfrentarse al pasado en el contexto del juicio popular contra Monteverde. La lujosa mansión del expresidente, una casa tomada, rodeada de manifestantes clamando por sus desaparecidxs, se volverá un espacio asfixiante capaz de atentar contra sus habitantes como respuesta a las demandas de justicia. Este artículo se interroga sobre tres aspectos fundamentales de la película. En primer lugar, cómo se elabora audiovisualmente el contra-archivo del juicio de Ríos Montt en 2013, de quien Monteverde es trasunto en la ficción. En segundo lugar, de qué manera se movilizan las politics of haunting negociando un discurso que transciende el género de terror y entronca con el de denuncia social. Y finalmente, cuáles son los procedimientos que utiliza el filme para presentar la resistencia indígena y la decolonialidad como opciones para construir el presente democrático en Guatemala.
Mapeo de los indicadores de gestión de la seguridad y salud en el trabajo en los procesos constructivos de las obras de centros educativos
Authors: Tovar Arredondo Freddy 
Published: July 2022

La presente investigación, busca establecer una de las metodologías para el establecimiento de una serie de indicadores de gestión en los proyectos de obras de construcción en centros educativos, con la finalidad de mejorar el desempeño en el seguimiento de la gestión de la seguridad y salud en el trabajo y así reducir el nivel de accidentabilidad en los trabajos de alto riesgo de las obras. El método utilizado para la elaboración de un mapeo de indicadores, consistió en la identificación de las etapas de los procesos constructivo de la obra de un centro educativo, seguidamente la selección de los indicadores de desempeño de seguridad y salud en el trabajo, de acuerdo a una serie de criterios establecidos como la identificación de peligros, evaluación de riesgos y medidas de control y los requisitos legales como el Decreto Supremo N° 011-2019-TR. Reglamento de Seguridad y Salud en el Trabajo para el Sector Construcción. La investigación sostiene que un mapeo de indicadores reactivos y proactivos bien identificados en los procesos constructivo de un proyecto de una obra en un centro educativo, conlleva al seguimiento eficaz en la medición de los objetivos y metas en la gestión de la seguridad y salud en el trabajo.
Phase-change materials for energy-efficient photonic memory and computing
Authors: Zhou Wen , Farmakidis Nikolaos , Feldmann Johannes , Li Xuan , Tan James , He Yuhan , Wright C. David , Pernice Wolfram H. P. , Bhaskaran Harish 
Published: July 2022

AbstractNeuromorphic algorithms achieve remarkable performance milestones in tasks where humans have traditionally excelled. The breadth of data generated by these paradigms is, however, unsustainable by conventional computing chips. In-memory computing hardware aims to mimic biological neural networks and has emerged as a viable path in overcoming fundamental limitations of the von Neumann architecture. By eliminating the latency and energy losses associated with transferring data between the memory and central processing unit (CPU), these systems promise to improve on both speed and energy. Photonic implementations using on-chip, nonvolatile memories are particularly promising as they aim to deliver energy-efficient, high-speed, and high-density data processing within the photonic memory with the multiplexing advantages of optics. In this article, we overview recent progress in this direction that integrates phase-change material (PCM) memory elements with integrated optoelectronics. We compare performances of PCM devices using optoelectronic programming schemes and show that energy consumption can be significantly reduced to 60 pJ using picosecond (ps) optical pulse programming and plasmonic nanogap devices with a programming speed approaching 1 GHz. With these energy-efficient waveguide memories, concepts of in-memory photonic computing are implemented based on crossbar arrays. Compared with digital electronic accelerators: application-specific integrated circuits (ASICs) and graphics processing units (GPUs), photonic cores promise 1−3 orders higher compute density and energy efficiency, although much more work toward commercialization is still required.Graphical abstract
Development of technology for deposition of thick copper layers onto ceramic substrates applied in power electronics
Authors: Nepochatov Yuri K. , Pletnev Pyotr M. , Kosarev Vladimir F. , Gudyma Tatiana S. 
Published: July 2022

The basic element of the design of a power module is a metallized ceramic substrate. In this work, the formation of metallization coatings by the method of thermal transfer of metallization pastes (Mo-Mn-Si + binder) for alumina and aluminum nitride ceramics was carried out. The fixing of the metallization coating on the ceramic substrate was performed by firing at a temperature of 1320 °C. The subsequent deposition of the copper layer was carried out by the method of cold gas-dynamic spraying (CGDS) followed by annealing of the deposited coating. For high-quality adhesion, the optimum annealing temperature was 1000 °C.
Removal of Pb2+ ions from synthetic wastewater using functionalized multi-walled carbon nanotubes decorated with green synthesized iron oxide–gold nanocomposite
Authors: Balamlile Z Zondo  , Olawumi O Sadare  , Geoffrey S Simate  , Kapil Moothi  
Published: July 2022

Purification of wastewater before it is discharged into the aquatic environment is important in order to prevent pollution of clean water. This study investigated the applicability of functionalized multi-walled carbon nanotubes (MWCNTs) decorated with gold-iron oxide nanoparticles for the adsorptive removal of Pb2+ from synthetic wastewater. CNTs were commercially obtained and functionalized with a mixture of H2SO4/HNO3 acids. The CNTs were coated with gold-iron oxide nanoparticles, to enhance the adsorption of heavy metals. The gold-iron oxide nanoparticles were synthesized by reacting green tea leaf extract with iron chloride (FeCl2) and gold (III) chloride (HAuCl4) precursors. The composite was cross-linked using N, N-dimethylformadide (DMF). The adsorbents were characterized using scanning electron microscopy (SEM) and transmission electron microscopy (TEM) to assess their surface morphology, Fourier transform infrared (FTIR) spectroscopy to identify the functional groups present, X-ray diffraction (XRD) to ascertain the crystallographic structure of the green adsorbent and Raman spectroscopy to determine the sample purity. SEM results showed highly agglomerated and polydispersed nanoparticles, owing to the presence of phytochemicals in the tea extract and magnetic interaction between the individual particles indicating the successful synthesis of Au/Fe3O4 adsorbent. Furthermore, an increase in the amount of Pb2+ removed per unit mass (qe) of adsorbent from 1.233 to 7.266 mg‧g-1 at 298 K was observed. A high sorption capacity was noticed for MWCNT-Au/Fe3O4 as compared to the MWCNT-COOH. The Pb2+ removal percentage increased from 50% to 78% with an increase in MWCNT-Au/Fe3O4 dosage from 0.02 g to 0.1 g. Adsorption isotherm data fitted well to the Freundlich and Langmuir isotherm models for MWCNT-COOH and MWCNT-Au/Fe3O4 adsorbents and the rate of Pb(II) adsorption by MWCNT-Au/Fe3O4 encountered an increase with increasing solution temperature and followed the pseudo-second-order model. The synthesized MWCNT-Au/Fe3O4 has good potential in removing heavy metals from wastewater.
Nova Scotia Strong: why communities joined to embrace COVID-19 public health measures
Authors: Steenbeek Audrey , Gallant Allyson , MacDonald Noni E. , Curran Janet , Graham Janice E. 
Published: July 2022

Abstract
Objective
To explore Nova Scotian experiences, barriers, and facilitators associated with pandemic public health measures (PHM), including COVID-19 vaccination.

Methods
We conducted semi-structured, individual interviews with Nova Scotians between May and August 2021, during the third wave of COVID-19 cases and provincial lockdown. Participants were recruited across the province from three sectors: decision makers, community leaders, and community members using purposive and snowball sampling. Direct content analysis and thematic analysis were used to identify key themes via the Theoretical Domains Framework.

Results
The experiences of 30 Nova Scotian interviewees clustered around four themes: Communication of PHM, Responsibly Observing PHM: A Community Coming Together, Navigating PHM, and Vaccine Confidence & Hesitancy. Consistent communication of PHM through briefings with the chief medical officer of health and provincial channels reduced misinformation and encouraged PHM compliance. While adherence was high throughout the province, inconsistent enforcement of these measures proved challenging to individuals navigating PHMs. A high level of COVID-19 vaccine confidence and acceptance was identified, and a strong sense of provincial pride prevailed in keeping COVID-19 numbers and transmission low.

Conclusion
This study provides insights into Nova Scotians’ unique experiences with COVID-19 PHM. Provincial public health experts and government leaders communicated PHM with various levels of success, Nova Scotia Strong, a sentiment of unity and communitarianism that sprang from public response to tragic events. Future work should aim to include under-represented communities to facilitate broader inclusion.
HLA-monomorphic determinants of the primary tumor in breast cancer patients
Authors: Chulkova S. V. , Sholokhova E. N. , Poddubnaya I. V. , Stylidi I. S. , Tupitsyn N. N. 
Published: July 2022

Background. Molecules of the major histocompatibility complex in cancer are currently being widely studied, and their clinical significance is still the subject of controversy. It is reported that they might have an important predictive value in the effectiveness of immunotherapy. The study of the expression HLA molecules status in breast cancer provides a deeper understanding of the biological properties of the tumor, in particular to identify the features of its immunological phenotype, which may further influence on breast cancer therapy.Aim. To evaluate the frequency of HLA-immunophenotypes in breast cancer and their relationship with the clinical and morphological features of the primary tumor.Materials and methods. This study included 82 patients with breast cancer who received treatment at the N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia. Immunophenotyping of the primary tumor was performed by immunofluorescence on cryostat sections. The reaction was evaluated using a ZEISS Axioscope 5 luminescent microscope (Zeiss AG, Germany). The study was dominated by patients with stage IIB 54 %, stage IIA was detected in 5 % of cases, IIIA – in 12 % of cases, IIIB – in 21 % of cases, IIIC – 8 %. Infiltrative ductal breast cancer was diagnosed in 67 % of patients (n = 55), infiltrative-lobular – in 22 % of cases (n = 18), other types – in 11 % (n = 9). The frequency of immunophenotypes was studied depending on the clinical and morphological characteristics of breast cancer.Results. It was found that in the group as a whole, the HLA-binegative immunophenotype of breast cancer was predominant. It dominated at stage T4 compared to the HLA-I+/HLA-DR+ phenotype (100 and 0 %), p = 0.042. At the same time, it should be noted that in T4 primary tumor the HLA-I+/HLA-DR– immunophenotype was also observed. The relationship this immunophenotype was noted with the stage: frequency at stage IIIA was higher than the HLA-I+/HLA-DR+ phenotype, 60 and 40 %, p = 0.01. Both HLA-DR-negative immunophenotypes were characterized by a high incidence of lymph node involvement and the absence of estrogen receptor expression. 80 % of receptor-negative tumors were noted in HLA-binegative immunophenotype compared to phenotype HLA-I+/HLA-DR+, p = 0.022; the similar data were obtained for the HLA-I+/HLA-DR– immunophenotype (p = 0.037).Conclusion. HLA immunophenotypes analysis of breast cancer revealed the HLA-binegative immunophenotype of breast cancer was predominant. The second most common immunophenotype was the absence of expression of HLA-DR molecules. The association of HLA-immunophenotypes with the stage of the tumor process, the size of the primary tumor, and the expression status of estrogen receptors was revealed.
Performance Analysis of Sharia Banking in Indonesia: Abu Zahrah Maqasid Shariah Index Approach
Authors: Suprayitno Eko , Haq Yunan Syaiful 
Published: July 2022

This study aims to analyze the performance of Islamic Banking (IB) in Indonesia through the maqashid shariah index Abu Zahrah approach. Performance appraisal on Islamic Banking (IB) is generally done through financial performance measurements without including non-financial performance measurements. Furthermore, this study uses descriptive quantitative research methods, namely an approach with a ratio value that can be calculated and described. The research object is 3 Islamic banks in Indonesia registered on the Indonesia Stock Exchange (IDX) and published their financial reports for 2018-2020. The results showed that Panin Dubai Sharia Bank obtained the best MSI score among 2 other Islamic banks with an MSI value of 38.59%. Furthermore, Bank BRI Sharia with an MSI score of 30.38%, and finally Bank BTPN Sharia with an MSI score of 30.24%. Panin Dubai Sharia Bank is more focused on achieving maqashid sharia aspects than the other 2 Islamic banks.
Effect of systemic lupus erythematosus on pregnancy outcome: a study of 40 cases at a tertiary health care center
Authors: Pereira Brynivalentina James , Patel Babulal S. , Shah Akshay C. , Parikh Purvi M. , Kumar Mahima M. 
Published: July 2022

Background: Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease in which organs and cells undergo damage initially mediated by tissue-binding autoantibodies and immune complexes. SLE has an impact on various organ systems. Ninety percent of the patients are women of child-bearing age thus pregnancies and its outcomes are of particular importance among women with SLE. The current study aims to study the maternal and foetal outcomes in SLE patients and to identify the predictors of adverse maternal and foetal outcomes in pregnancy.Methods: Data of 60 pregnancies of 40 female SLE patients from September 2019 to May 2021 in V. S. general hospital, Ahmedabad, were retrospectively reviewed. All the patients met the 2012 SLICC classification criteria for SLE. SLE disease activity in pre-pregnancy state and during pregnancy were retrospectively evaluated using SLE disease activity index-(SLEDAI), based on medical history, physical examination and immunological evaluation. SLE disease activity during the current non pregnant state was also calculated using SLEDAI.Results: In our study carried out 3 years among 60 pregnancies, the disease flared up in 23 pregnancies (38.3%). Out of 60 pregnancies with SLE, there 17 (28.3%) unfavourable outcomes. Unfavourable outcomes were significantly higher in patients with SLE flare (14, 60.9%). Similarly, patients with lupus nephritis (8, 66.7%) had unfavourable outcome.Conclusions: In spite of tertiary level care in the hospital, foetal loss is a significant risk in these patients, so proper periconceptional counselling should be done
Neutrophil to lymphocyte ratio and correlation with hepatic fibrosis in patients with chronic hepatitis B
Authors: Shivalingappa Umashankar Uyigowdanahally , Ramasamy Akilandeshwari Alagan , Muhammed Kani Shaikh , A. Anand , N. Arun 
Published: July 2022

Background: Chronic hepatitis B (CHB) is a dynamic condition involving interaction between the hepatitis B virus, hepatocyte and host immune system. Neutrophil-lymphocyte ratio (NLR) is a cheap, easily available bedside inflammatory marker. The aim of the study was to assess the role of NLR to assess the fibrosis in CHB patients Methods: It was a prospective cross-sectional study done between January 2021-December 2021, 61 patients with CHB of age 16-50 years were included. Basic demographic and laboratory parameter were assessed. Fibrosis was assessed using fibroscan (ECHOSENS) 502 model. Using NLR cut-off of 1.9 fibrosis was assessed in different groups.Results: The mean age was 34±13.1 years, 66% were male patients. The mean haemoglobin, total count, platelet counts were 11.3±2.1 g/dl, 7250±2100 cells/ml, 146000±26000/ml respectively. The 38 (62.3%) patients were HBeAg positive and 23 (37.7%) patients HBeAg negative. The 28 (45.1%) patients had no significant fibrosis (<8 kpa) and 33 (54.09%) patients had significant fibrosis (>8 kpa). The 33 patients with significant fibrosis 30 patients had NLR of less than 1.9 and 3 had NLR>1.9. The 28 patients who had fibrosis of less than 6.5 kpa, 26 had NLR more than 1.9 and 2 patients with less than 1.9. Mean N/L ratio values were notably lower in cases with advanced fibrosis when compared to individuals with no/minimal fibrosis (p<0.0001). APRI was among 0.32±0.18 and 0.86±0.21 among patients with NLR<1.9 and >1.9 respectively (p=0.0001)Conclusions: Decreased N/L ratio is significantly associated with fibrosis severity and can be utilised to identify patients with advanced disease.
A Clinico-Radiological analysis of morbidity and mortality in COVID-19 patients admitted in a dedicated covid hospital of eastern India
Authors: Dubey Roopak , Sen Kamal Kumar , Mishra Aparajita 
Published: July 2022

CT scoring helps to stratify patient’s risk and predict short-term outcome of patients with COVID-19 pneumonia. we aim to assess the severity of COVID by examining the variations and degree of the pulmonary involvement on the HRCT thorax. We observed trend of increasing severity of COVID as predicted on HRCT in Eastern India population.HRCT Thorax of 2000 consecutive COVID positive patients were analysed to look for the patterns of lung involvement and to calculate a CT severity score. The CT severity score was compared with laboratory parameters like D-Dimer, CRP, ESR, Procalcitonin, WBC and Lymphocyte count by Pearsons correlation analysis.Out of 2000 COVID positive patients 1220 (61%) patients were found to be radiologically positive on HRCT chest imaging while 780 patients (39%) had normal CT findings.Out of the 62 patients who died, 54 ( 87%) were having CTSS of &#62; 15. Among the dead patient the prevalence of one or more comorbidities was significantly higher (49/62 patients, 79%) The proportion of patients having CT severity score between 16-25 (Severe patients) had increased from 4% in April-May to 27% in August.Trend of severity among COVID patients increased as the months passed from April to August. Most of the deaths in our cohort were associated with pre-existing comorbidities suggesting that the COVID was not the sole cause of these deaths. Among the biochemical markers D-Dimer and CRP correlated well with the CT severity score.
Demographic pattern and visual outcome in patients with open globe injury
Authors: Kadir Syeed Mehbub Ul , Akther Rehana , Sultana Chandana , Salam Abdus , Abdullah Muhit , Sultana Saleha , Shahid Muntakim , Muyeed Abdul , Sultana Monira , Maurya Rajendra Prakash 
Published: July 2022

: This study aimed to assess the demographic and clinical characteristics, prognostic factors, and visual outcomes of open globe injury on the repair. This was a retrospective cross-sectional study including all patients who underwent repair surgery following open globe injury and are on regular follow-up visits postoperatively in a tertiary eye hospital from 1st July to 31st December 2021. Patients were divided into two groups. Group A include OGI patients undergoing repair within 24 hours, and Group B includes OGI patients who underwent repair after 24 hours of injury. All the study patients were studied in detail, including the Presenting features, mechanism of injury, preoperative and postoperative visual acuity, demographic data, and postoperative complications. This study studied a total of 100 patients (46 in group A and 54 in group B). Male predominance (&#62;70%) was seen in both groups. In both groups, the highest number of patients (61% in group A and 52% in group B) were in ≤18 years of age. In both groups, the majority of OGI (52% in group A and 61% in group B) were Iron induced. In groups A and B, Zone I is affected chiefly, about 85% and 81%, respectively. Most OGI patients were admitted to the hospital with severe low vision on VA examination, about 54% and 63% in Group A and B, respectively. At three months of postoperative follow-up, BCVA was significantly improved In Group A than in Group B (p-value 0.05). 80% patients improved to normal vision in group A compared to 50% in group B. Open globe injuries should be repaired as soon as possible, even within hours. Initial visual acuity remains the strongest predictor of outcome; however, delay to primary repair reduces final visual acuity.