bluuebunny/crossref_metadata_2025_split huggingface dataset:
Choice, Attitudes, and Perceptions of Undergraduate Nursing Students towards the Nursing Profession
Authors: Neumbe Irene Mildred , Ssenyonga Lydia , Soita David Jonah , Iramiot Jacob Stanley , Rebecca Nekaka 
Published: June 2022

Abstract
Background: Nursing students are the upcoming contributors to the nursing workforce and their attitudes towards the profession depict the quality of care they will offer to patients upon qualification. This study aimed to determine the reasons for choice, attitudes, and perceptions of undergraduate nursing students towards their profession.Methods: This cross-sectional study involved 165 nursing students from year one to year four registered in the two public universities in Uganda. The Attitude Scale for Nursing Profession was used to collect quantitative data. Focus Group Discussions were held to collect qualitative data about the reasons for choice and perceptions towards the nursing profession.Results: Students chose the nursing program because of its availability, poor academic performance in high school, desire to pursue a medical-related course, failure to get admitted for Medicine and Surgery, low cut-off points for the Nursing course, and interest in nursing. The majority of the students (81.8%) had positive attitudes towards the nursing profession. There was a statistically significant difference between the mean attitude scores of nursing students according to the year of study, entry scheme into the University, and source of funding for the program. Perceptions about the nursing profession were based on their personal experiences, experiences of colleagues, and observation of how nurses are treated at work. Conclusion: Although nursing students had positive attitudes towards the nursing profession, the majority of their perceptions about the profession were negative.Nursing training institutions should ensure that students receive pre-nurse counseling and introductory courses about the profession to enhance the acquisition of an accurate perception of the nursing profession.
Estrogen related receptor β mediated regulation of SIRT1 in breast cancer progression
Authors: Naik Sanoj K , Prakash Surya , Krishna B. Madhu , Parija Monalisa Parija , Dash Sanghamitra , Choudhury Sanjib , Mishra Dipti Ranjan , Sahoo Shashi Bhusana , Mishra Sandip K K 
Published: June 2022

Abstract
Silent mating type information regulation 2 homolog 1 (SIRT1) is an NAD+ dependent class III histone deacetylase (HDAC) which plays a vital role in cell survival, senescence and metabolism. SIRT1 is overexpressed in several cancers, including breast cancer. Due to the lack of endocrine therapy for ER-ve breast cancers, it is essential to identify the molecular targets having therapeutic importance. SIRT1 is a known target gene of estrogen receptor α (ERα) and well associated with ERα deacetylation. Transcription factor Estrogen related receptors (ERRs) share sequence homology with ERs in DNA binding domain, therefore possibility of sharing target genes between them is high. Our present study aim to elucidate the role of ERRβ in the regulation of SIRT1 in breast cancer tumorigenesis. SIRT1 was highly up-regulated in ER + ve breast cancer cells and tissues. Analysis of 5’ upstream region of SIRT1 suggested the presence of six putative ERRE sites and in-vitro and in-vivo studies confirmed the binding of ERRβ to them. We found SIRT1 to be up-regulated in ERRβ overexpressed ER + ve breast cancer cells. Furthermore, our results suggested the up-regulation of SIRT1 upon ectopic expression of ERRβ along with PCAF. We also proved the tumorigenic role of SIRT1 with enough evidence showing the significant role of SIRT1 in cell proliferation, migration and colony formation capacity. Collectively our results suggest the tumorigenic role of SIRT1 in the breast cancer and SIRT1 inhibitors might serve as potential therapeutic drugs for the treatment of breast cancer.
Extension of the Composite Quality Score (CQS) as an appraisal tool for prospective, controlled clinical therapy trials (Preprint.v.2)
Authors: Mickenautsch Steffen , Rupf Stefan , Miletić Ivana , Yengopal Veerasamy 
Published: June 2022

Abstract
Aim: to conduct a survey of current meta-epidemiological studies to identify additional trial designcharacteristics that may be associated with significant over/under estimation of the treatment effectand to use such identified characteristics as basis for the formulation of new CQS appraisal criteria.Materials and methods: We retrieved eligible studies from two systematic reviews on this topic(latest search May 2015) and searched the databases PubMed and Embase for further studies fromJune 2015 – March 2022). All data were extracted by one author and verified by another. Sufficientlyhomogeneous estimates from single studies were pooled using random-effects meta-analysis. Trialdesign characteristics associated with statistically significant estimates from single datasets (whichcould not be pooled) and meta-analyses were used as basis to formulate new or to amend existingCQS criteria.Results: A total of 38 meta-epidemiological studies were identified. From these, seven trial designcharacteristics associated with statistically significant over- or under estimation of the truetherapeutic effect were found.Conclusion: One new criterion concerning double blinding was added to the CQS and the originalcriteria for concealing the random allocation sequence and for minimum sample size amended.
Glycyrrhizic Acid alleviate the Neurotoxicity of Semen Strychni through inhibition of HMGB1 phosphorylation and inflammatory
Authors: Yu Changwei , Xiang Yalan , Zhang Min , Wen Jing , Duan Xiaoyu , Wang Lu , Deng Gongying , Fang Pingfei 
Published: June 2022

Abstract
Backgrounds : In recent years, the neurotoxicity of Semen Strychni was reported in many clinical cases. Hence，this study was conducted to investigate the role of HMGB1 in the model of neurotoxicity induced by Semen Strychni and the alleviation of glycyrrhizic acid, which is related to the regulation of HMGB1 release. Methods: The rats were intraperitoneally injected with Semen Strychni extract (175mg/kg), followed by oral administration ofglycyrrhizic acid (50 mg/kg) for 4 days. After treatment, neuronal degeneration, apoptosis, and necrosis were observed by Nissl, FJB, and Tunel. ELISA was used to detect related inflammatory indicators TNF-α, IL-1β, HMGB1, and neurotransmitter enzymes MAO, AChE. IF and Western Blot were used to determine the localization of HMGB1, p-HMGB1, and NF-κB in the nucleus and cytoplasm; CO-IP was used to determine the interaction between PP2A, PKC, CaMKIV and HMGB1. The expression of ERK, p-ERK, JNK, p-JNK, p38, p-p38, was detected by Western Blot . Results: After neurotoxic model rats were treated with glycyrrhizic acid neuronal damage and apoptosis were improved to a certain extent, the inhibitory effect of Semen Strychni on neurotransmitter metabolic enzymes was removed, and the levels of inflammatory indexes TNF-α and IL-1β were also significantly down-regulated. The results of IF and Western Blot showed that Semen Strychni reduced the nucleus level of HMGB1, significantly increased the cytoplasm and serum release levels, and increased the level of p-HMGB1, while glycyrrhizic acid could down-regulate the level of p-HMGB1, inhibit the nucleoplasmic shuttle and extracellular release process of HMGB1. Glycyrrhizic acid could strengthen the interaction between HMGB1 and PP2A and reduce the combination of HMGB1 and PKC. Glycyrrhizic acid significantly down-regulated the expression levels of p-ERK, p-JNK, and p-p38 proteins, and inhibited the transfer of NF-κB from the cytoplasm to the nucleus. Conclusions: Glycyrrhizic acid has a certain ameliorating effect on the neurotoxicity induced by Semen Strychni, and its mechanism is related to the inhibition of HMGB1 phosphorylation, the reduction of nucleoplasmic shuttle, and the inhibition of downstream inflammatory pathways of HMGB1.
Facing a serious problem: how to treat specific critical population without recommendations from current clinical practice guidelines
Authors: Chen Weiting , Zhong Li , Zheng Cheng , Ding Wenyun , Zhang Kai , Xuan Nan xia , Cao Lanxin , Tian Baoping , Cui Wei , Wang Pingli , Zhang Zhongheng , Zhang Gensheng 
Published: June 2022

Abstract
Objective: Some special populations are always excluded from Clinical Practice Guidelines (CPGs), the study was attempted to analyze the characteristic and categories of excluded populations from the relevant CPGs from the field of Critical care medicine (CCM).Methods: Electronic databases of PubMed and Scopus were searched from October 9, 2016 to October 9, 2020. The search strategy consisted of key terms related to critical care and guidelines. Each included CPG was examined for full text to identify the randomized controlled trials (RCTs) in the reference. Each included RCT was examined for full text to identify the excluded subjects. Required data from the eligible RCTs and all data were extracted by two reviewers.Results: A total of 33 publications of CPGs were included, consisting of 1134 recommendations including 1231 RCTs. 91.3% of RCTs had exclusion criteria. The exclusion criteria for the top five rankings in the 1231 RCTs were as follows: patients with age <18 years (37.9%), pregnant (29.5%), moribund (19.2%), surgical history (14.8%), renal impairment (14.2%). Twenty topics were finally categorized from these 33 CPGs. The top five rankings of exclusion criteria in these topics included age < 18 years (100%, 20/20), pregnant women (85%, 17/20), moribund (60%, 12/20), surgical history (30%, 6/20) and renal impairment (30%, 6/20).Conclusion: CPGs from the field of critical care medicine (CCM) always exclude some special populations including who are age <18 years, pregnant women, moribund, surgical history, and renal impairment, while these kinds of populations are needed more attention.
Determine the complete configuration of single carbon nanotubes by one photograph of transmission electron microscopy
Authors: Yu Yue , Zhao Yifan , Wang Shanshan , Liu Weiming , Zhao Chao , Ding Feng , Zhang Jin 
Published: June 2022

Abstract
Complete structural determination of single walled carbon nanotubes (SWNTs), including chiral indices (n,m) and handedness, is significant for their full functionality exploration. However, handedness identification at the atomic level in real space imaging without sample tilting is challenging. Here, we apply aberration-corrected transmission electron microscopy to characterize artificially constructed SWNTs/graphene (Gr) vertical heterostructures with aligned interfaces. The lattice of the SWNT upper and lower walls can be distinguished separately, thus unclosing the handedness, which is a 3D structural feature, in projected 2D space. Gr displays prominent out-of-plane deformation at the interface, remarkably promoting the energetic advantage for the aligned interface construction with diversified alteration to the electronic structure of SWNTs based on density functional theory calculations. 27 specimens with SWNTs prepared by two disparate methods are examined, implying potential handedness enrichment in SWNT horizontal arrays grown on a-sapphire. Our work provides a facial strategy for chiral discrimination with sub-angstrom resolution and lays a characterization foundation for handedness-selective growth of nanomaterials.
Comparison of Peripapillary Vascular Density Measured by Optical Coherence Tomography Angiography in Different Open-Angle Glaucoma Types
Authors: Simsek Merve , Oral Yesim , Inan Sibel , Akdogan Muberra , Sabaner Mehmet Cem 
Published: June 2022

Abstract
Purpose: In this study, we aimed to found whether there is a difference between the primary open-angle glaucoma (POAG), pseudoexfoliative glaucoma (PXG) and pigmentary glaucoma (PG) cases, which are open-angle glaucoma types, or not, in terms of peripapillary retinal nerve fibre layer (RNFL) and peripapillary vascular density measured by optic coherence tomography angiography (OCTA). Methods: 27 eyes of 27 patients with diagnosed POAG, 34 eyes of 34 patients with diagnosed PXG, 20 eyes of 20 patients with diagnosed PG who went to the glaucoma unit between June 2019 and January 2020 and 15 eyes of 15 healthy individuals without ocular pathology were included in our retrospective, cross-sectional study except for presbyopia in the control group and ± 1.0 D refractive error. Peripapillary RNFL measurement was performed with OCTA, and small vessel density measurements were performed with all images (AI-DD), intra-disc (ID-DD) and peripapillary (PP-DD) for the finding of vascular density in the radial peripapillary capillary network. Kruskal Wallis test and post hoc test were performed for statistical analysis. Results: There was no statistically significant difference between the groups in terms of age and gender. AI-DD was 50.83±2.03% in the healthy group, 47.12±2.57% in primary open-angle glaucoma, 39.71± 6.64% in pseudoexfoliative glaucoma, and 43.37±1.55% in pigmentary glaucoma. ID-DD was 51.61± 3.68% in the healthy group, 49.51 ± 6.83% in primary open-angle glaucoma, 38.42±13.46% in pseudoexfoliative glaucoma, and 40.9±4.45% in pigmentary glaucoma. PP-DD was 52.62±2.65% in the healthy group, 50.13 ± 3.04% in the primary open-angle glaucoma, 42.31 ± 7.31% in the pseudoexfoliative glaucoma, and 47.6±1.40% in the pigmentary glaucoma group. While it was found that all image and intra-disc small vascular density measurements were statistically significantly lower in the pigmentary glaucoma and pseudoexfoliative glaucoma group compared to the healthy group and the primary open-angle glaucoma group (p<0.001), there was no significant difference between PXG and PG and between the control group and the POAG group. Conclusions: Being lower radial peripapillary capillary density in PXG and PG compared to the POAG and healthy group suggests that the blood flow around the optic disc is negatively affected in these patients.
Biocontrol Agents of Bacillus velezensis wr8 against Penicillium sp
Authors: Wang Rui , Wang Xiaohu , Weng Yuting , Lan Baofeng , Zhou Liqin , Yang Hui 
Published: June 2022

Abstract
Blue mold caused by Penicillium sp is one of the most serious postharvest diseases of citrus fruit. The aim of this study was to isolate and identify native Bacillus with inhibition phenotypes of citrus plants fruits. We investigated the antifungal effect of Bacillus velezensis wr8 on the postharvest pathogens Penicillium sp inoculated on fruits, as well as on the growth of these fungi on Petri dishes with defined media. MALDI-TOF MS was conducted to illuminate the underlying mechanism. Results showed that Bacillus velezensis wr8 significantly inhibited Penicillium sp growth in vitro. Moreover, secondary metabolites suppressed the disease development of citrus fruits inoculated with Penicillium sp in 25℃. Furthermore, MALDI-TOF MS indicated that lipoprotein with the molecular mass of 30.2 kDa was a key component about against Penicillium sp. In addition, the secondary metabolites with antibacterial activity against Escherichia coli showed antimicrobial peptide with the molecular weight of 9.8 kDa. These results demonstrated that Bacillus velezensis wr8 could produce lipoprotein and antimicrobial peptide to inhibit Penicillium sp and Escherichia coli which has broad application prospect in the future development. Finally, Bacillus velezensis wr8 is to provide data support for the development and utilization of high activity bacteriocin at room temperature and its application in the field of food safety.
Long Term Use of Social Networking Sites by Nepali CSOs
Authors: Regmi Nischal , Pandey Shailesh 
Published: June 2022

Abstract
We examine whether the nonprofits in Nepal and India have used Twitter effectively to keep their stakeholders engaged with them in the long-term of around five years. We also examine how the nonprofits can be classified according to their long-term tweet behavior. We introduce a two-step process for tweet classification that considers both the nonprofits’ tweets and their targeted audience, and apply the k-means algorithm to observe the clusters of nonprofits according to their long-term Twitter use. Our exploratory analysis shows that the majority of nonprofits in Nepal and India have not used Twitter with an objective of keeping their stakeholders engaged. We end by suggesting a few research questions that need to be answered for a better understanding of SNS use by nonprofits.
A whole high-accuracy numerical calculation system for the 1D Poisson equation by the interpolation finite difference method
Authors: Fukuchi Tsugio 
Published: June 2022

Abstract
The interpolation finite difference method (IFDM) allows free numerical analysis of elliptic partial differential equations over arbitrary domains. Conventionally, in the finite difference method (FDM), the calculation is performed using the second-order accuracy central difference. For engineering problems, second-order accuracy calculations are often sufficient. On the other hand, much research has been done on improving the accuracy of numerical calculations. Although there is much research in the field of FDM, the development of numerical calculations by the spectral method is decisive in improving calculation accuracy. Numerical calculations are usually performed by double precision calculations. If double precision calculations ensure 15 significant digits in floating point computing, such numerical calculations will be the ultimate goal to reach. A numerical calculation that does not seem to have an error even though it originally has an error is defined as a virtual error-zero (VE0) calculation. In this paper, we will examine an overall picture of high-accuracy numerical calculation by IFDM in the numerical calculation of the 1D Poisson equation. It becomes clear that a VE0 calculation is always possible in the numerical calculation method defined as the compact interpolation finite difference scheme (CIFD(m)).
Preparation and Quality Evaluation of Honokiol Nanoparticles Using a
New Polysaccharide Polymer as its Carrier
Authors: Xiong Yang , Weng Ye , Zhang Hongyan , Xu Shujun , Zhao Yue , Ma Lisha , Shi Jingbin , Qian Ke , Liang Weizong 
Published: June 2022

Objective:
To improve solubility of Honokiol (HNK), Honokiol nanoparticles (HNK-NPs) were prepared by using a new biodegradable polysaccharide polymer as its carrier.

Methods:
HNK-NPs were prepared by hydrophilic polymer coagulation method, and the processing parameters were optimized according to average particle size and PDI by single factor experiment. The morphology of the optimized nanoparticles was investigated by TEM and the in vitro release was carried out to evaluate the optimized HNK-NPs.

Results:
The encapsulation efficiency and drug loading of the HNK-NPs were 77.75 ± 2.63% and 13.46 ± 0.39%. The obtained nanoparticles of HNK-NPs were spherical-like under the electron microscope with a mean particle size of 198.50 ± 0.01 nm and Zeta potential of −52.60 ± 1.00 mV, respectively. The in vitro release results showed that the cumulative release rates of nanoparticles were 48.28 ± 9.80% and 81.12 ± 4.35% within 2 h and 8 h, respectively which showed a stable release behavior. The average particle size and PDI of HNK-NPs solution prepared by hydrophilic polymer condensation method had no obvious change at 72h.

Conclusion:
HNK-NPs were successfully prepared by phase separation method. This new polysaccharide polymer should be an ideal carrier to help improving the solubility of HNK.
Escrita andarilha. Nietzsche e a literatura contemporânea de língua portuguesa
Authors: Trevizan Suelen Ariane Campiolo 
Published: June 2022

Ao enfatizar a historicidade de certos valores predominantes em sua época, Friedrich Nietzsche questionava a aura de universalidade que revestia a cultura europeia moderna e seus agentes. Sua crítica à metafísica contribuiu para detonar uma crise epistemológica que atravessou o século XX e segue em curso até hoje. Embora seu legado nas ciências humanas seja amplo e variado, este artigo traz para o primeiro plano exemplos de como esse diálogo ocorre na literatura contemporânea de língua portuguesa. Com isso, procura-se observar a especificidade de como algumas obras respondem ao filósofo. O corpus selecionado contempla quatro textos: O livro das comunidades, de Maria Gabriela Llansol; “O mundo estranhado: esboço de filosofia fisionômica”, de Juliano Garcia Pessanha; “Duas pessoas”, de Herberto Helder; e “Floema”, de Hilda Hilst. Nos dois primeiros, analisamos como reelaboram a ideia nietzschiana do eterno retorno; nos dois últimos, o perspectivismo. Em vez de se estabelecerem generalizações e consensos, destacamos os diversos acenos que fazem à vivência e à escrita entendidas como singular transformação. Em suma, essas expressões literárias afastam-se de um viés substancialista para se manifestar como performance, daí sua estrutura móvel, andarilha.
mHealth Research for Weight Loss, Physical Activity, and Sedentary Behavior: Bibliometric Analysis
Authors: Wu Chieh-Chen , Huang Chih-Wei , Wang Yao-Chin , Islam Md.Mohaimenul , Kung Woon-Man , Weng Yung-Ching , Su Chun-Hsien 
Published: June 2022

Background
Research into mobile health (mHealth) technologies on weight loss, physical activity, and sedentary behavior has increased substantially over the last decade; however, no research has been published showing the research trend in this field.

Objective
The purpose of this study was to provide a dynamic and longitudinal bibliometric analysis of recent trends of mHealth research for weight loss, physical activity, and sedentary behavior.

Methods
A comprehensive search was conducted through Web of Science to retrieve all existing relevant documents published in English between January 1, 2010, and November 1, 2021. We developed appropriate research questions; based on the proven bibliometric approaches, a search strategy was formulated to screen the title for eligibility. Finally, we conducted bibliometric analyses to explore the growth rate of publications; publication patterns; and the most productive authors, institutions, and countries, and visualized the trends in the field using a keyword co-occurrence network.

Results
The initial search identified 8739 articles, of which 1035 were included in the analyses. Our findings show an exponential growth trend in the number of annual publications of mHealth technology research in these fields. JMIR mHealth and uHealth (n=214, 20.67%), Journal of Medical Internet Research (n=71, 6.86%), and BMC Public Health (n=36, 3.47%) were the top 3 journals, publishing higher numbers of articles. The United States remained the leading contributor in these areas (n=405, 39.13%), followed by Australia (n=154, 14.87%) and England (n=125, 12.07%). Among the universities, the University of Sydney (n=36, 3.47%) contributed the most mHealth technology research in these areas; however, Deakin University (n=25, 2.41%) and the National University of Singapore (n=23, 2.22%) were in the second and third positions, respectively.

Conclusions
Although the number of papers published on mobile technologies for weight loss, physical activity, and sedentary behavior was initially low, there has been an overall increase in these areas in recent years. The findings of the study indicate that mobile apps and technologies have substantial potential to reduce weight, increase physical activity, and change sedentary behavior. Indeed, this study provides a useful overview of the publication trends and valuable guidance on future research directions and perspectives in this rapidly developing field.