bluuebunny/crossref_metadata_2025_split huggingface dataset:
Application and short-term effect of enhanced recovery after surgery on robotic distal gastric cancer surgery
Authors: Liu shan , wang chun , xing zhaodong , wang yuna , cai guohao , huang ping 
Published: June 2022

Abstract
Backgroud Robotic distal gastrectomy (RDG) has been increasingly used for the treatment of gastric cancer (GC). At the same time, enhanced recovery after surgery(ERAS) [1]has been increasing used in all kinds of operations. However,how the clinical effect of ERAS combined with RDG yet to be researched more. Thus, this study aimed to To evaluate the feasibility and efficacy of Robotic distal gastrectomy (RDG) and enhanced recovery after surgery(ERAS)[2] Methods In total, 52 patients were enrolled between July 2020 and January 2022 in this retrospective study.26 patients underwent Robotic distal gastrectomy (RDG) was adopted with routine perioperative intervention while 26 patients adopted the ERAS mode.the general date(age,gender,BMI index,underlying disease),perioperative data(operationg methods postoperative hospital stay,postoperative inflammation:C-reactive protein,postoperative ambulation time,postoperative liq-uid food intake time,postoperative anal exhaust time,operation time,the number of lymph node dissection,intraoperative blood loss, hospitalization expenses,postoperative hospital stay), postoperative complication were compared between the two groups. Results There is no different significantly in the general date ,operation time,the number of lymph node dissection, intraoperative blood loss between this two groups(p > 0.05), ERAS [3]concept showed its advantages in release postoperative inflammation,reduce postoperative hospitalization stay and cost,cut down postoperative anal exhaust time ,reduce postoperative complication (P < 0. 01). Conclusions Collectively, ERAS results in accelerated convalescence, reduction of surgical stress and medical costs, improved nutritional status, and better quality of life for gastric cancer patients. However, high-quality multicenter randomized controlled trials with large samples and long-term follow-up are needed to more precisely evaluate ERAS in RDG.
Effect of fruits intake on functional constipation: a systematic review and meta-analysis of randomized and crossover studies
Authors: Gao Hua , Huo Jinghong , Cao Hongdou , Gao Qinghan 
Published: June 2022

Abstract
Functional constipation (FC) is commonly treated with fruits whose efficacy remain unclear. We conducted a meta-analysis of fruit intervention for FC and provided evidence-based recommendations. We searched seven databases from inception to April 2022. All randomized and crossover studies of the effectiveness of fruits on the FC were included. We conducted sensitivity and subgroup analysis. A total of 11 studies were included in this review at last. Four trials showed that kiwifruits have significantly increased the stool frequency (MD=0.26, 95% CI (0.22, 0.30), P＜0.0001, I2=0%) than palm date or orange juice in the fixed-effect meta-analysis. Three high-quality studies suggested that kiwifruits have better effect than ficus carica paste on the symptom of the FC assessed by the Bristol stool scale in the fixed-effect meta-analysis (MD=0.39, 95% CI (0.11, 0.66), P＜0.05, I2=27%). Besides, five trials showed that fruits can increase the Lactobacillus acidophilus (MD=0.82, 95% CI (0.25, 1.39), P＜0.05, I2= 52%) analysed with random-effect model. Subgroup meta-analysis according to the types of fruits suggested that fruits including pome fruit, citrus fruit and berries have increased the Bifidobacterium than the stone fruits in the random effect meta-analysis (MD=0.51, 95% CI (0.23, 0.79), P ＜ 0.05, I2=84%). Totally, fruits intake may have potential symptom alleviation on the FC as evidence shows they can affect stool consistency, stool frequency and gut microbiota. Further large-scale studies in clinic are needed to gain more confident conclusions concerning the association between fruits intake and FC.
Modified Serial Techniques “ASTRO” Faciliated Laparoscopic Total Mesorectal Excision for ultralow-Lying Rectal Cancer in Obese Male Patients
Authors: Yin Yefeng , Zhuang Meng , Hu Xiyue , Liu Jungguang , Mei Shiwen , Tang Jianqiang 
Published: June 2022

Abstract
Background
Laparoscopic total mesorectal excision (LaTME) is technically challenging for ultralow-lying rectal cancer in obese male patients. Herein, we introduced modified serial techniques “ASTRO” to facilitate LaTME, and the short-term outcomes were presented.
Methods
A prospective study (NCT05067413) was conducted between December 2020 and January 2022. The modified serial surgical techniques “ASTRO” included 5 key steps: 1) Anterior peritoneal reflection (APR) dissection at the highest line along with a "n"-shaped membrane bridge; 2) Suspending the APR with a purse-string suture through the bladder peritoneum to enlarge the operating space of the anterior rectal wall; 3) Traction and counter-traction continuously of the rectum applied with a cotton tape around the rectum; 4) Resection of the pelvic rectum on tripartition, followed by the sequence of "posterior > anterior > lateral" principle; 5) the trans-anterior Obturator nerve gateway was adapted to transect the distal rectum. The operative data and postoperative short-term outcomes were collected.
Results
24 consecutive patients underwent this procedure successfully. The average body mass index (BMI) was 29.9 ± 1.3. The average of tumor height from anal verge was 4.0 cm (range, 3.0–4.5 cm). The median operating time and blood loss was 217 min (range,165–420 min) and 50ml (range,20–100 ml) respectively. The anterior operation space at the midsagittal plane of the pelvis inlet was increased by 2.0 ± 0.3 cm. The calculated dominant angle was 20 ± 3°. The length of stapling line was 6.8 ± 1.0 cm with 11 cases by one cartridge and 13 cases by 2 cartridges. 8 patients developed postoperative complications including 4 with anastomosis leakage (16.7%), 2 with urinary retention (8.3%), one with anastomotic stenosis (4.2%) and one with ileus (4.2%). All the complications were relatively mild and recovered well.
Conclusion
Modified Serial Techniques “ASTRO” could expand the operating space and facilitate LaTME in obese male patients, thereby reducing the risk of conversion to open and transanal dissection.
Cr, Fe-MOF/ Graphene Hybrid Nanocomposite for Ultra Removal of Organic Sulfur Compounds from Diesel Fuel
Authors: Matloob Aya M. , El-Hafiz Dalia R. Abd , saad lamia , Mikhail S. 
Published: June 2022

Abstract
Metal-organic frameworks (Cr-MOF and Fe-MOF) and their graphene hybrid nano-composites were prepared via the green solvo-thermal method. The prepared samples were characterized by XRD, FTIR spectroscopy, N2 adsorption-desorption isotherm, and XPS. The composites were used for the adsorption of thiophenic sulfur compound (thiophene, dibenzothiophene, 4,6-dimethyldibenzothiophene) in a model fuel oil. It was found that graphene in the MOF composite has a positive effect on sulfur removal. The removal efficiency increase from 62 % to % 95.6 using Fe-MOF and Fe-MOF/Gr (9:1), respectively. This enhancement effect is attributed to a higher number of coordinatively unsaturated sites (CUS) in the composites. The results indicated that the adsorption reaches to 96.6% for DBT adsorption from model diesel oil and 62% for diesel fuel on using Cr-MOF/Gr composite.
Hydrodynamical numerical assessment of the recent droughts at Gallinas River, San Luis Potosí, Mexico
Authors: Rodríguez-Cuevas Clemente , Hernández-Antonio Arturo , Hernández-Gómez Jorge J. , Padilla-Pérez Diego , Couder-Castãneda Carlos 
Published: June 2022

Abstract
Water scarcity is estimated to be a significant threat to societies worldwide, such as food shortages and hygiene problems. In 2016-2020, during the dry season, the Gallinas River in San Luis Potosí State, Mexico, experienced a complete loss of its downstream flow. These events severely impacted the locality’s economy and never registered before. Consequently, the flow disappears at the Tamul waterfall. To investigate the causes, this research focuses on identifying the flow variations in different river sections. To find the causes of flow losses in the Gallinas River, which has been affected by the temporary disappearance of the waterfall, the EFDC model was used and calibrated based on data from measurement campaigns that took place from 2017 to 2018. This model was applied under five different scenarios of inflow boundary conditions: 1.5, 30,60, and 1000 m 3 /s. Data collection methods include in situ measurements of flow and speed, photogrammetry, numerical modeling, bathymetry, and digital elevation modeling. It can be concluded that the most likely reason for the flow variations in the river is the influence of the geology that would generate specific infiltrations and the geological configuration of the GallinasRiver reveals why upstream the river seems to carry a considerable flow.
Assessing the Effect of Natural Forest Conversion to Coffee-Based Forest on Soil Carbon Stock at Anfilo District, West Ethiopia
Authors: Daka Yohannes Shifera 
Published: June 2022

Abstract
Background: Natural forest degradation for coffee management and intensification in natural forest has been playing a great role in affecting forest carbon (C) stock potential in western and southwestern Ethiopia which is not studied well. By considering this issue, the current study was conducted with the aim to assess the soil C stock changes as a result of conversion of natural forest to coffee-based forest at Anfilo District, western Ethiopia. The District is 642 km west of Finfinne (The country’s capital city). For the present study, two adjacent land uses, protected natural forest (PNF) (1,576 ha) and forest with coffee (FWC) (2,364 ha) were considered. In light of this, soil samples were collected for the analysis of C content and bulk density (BD). Soil samples were taken by using ‘‘X’’ design from land size of 1mx1m (four at corners for C content and one in the center for BD analysis) at two levels of soil depths (0–20 and 20–40 cm) separately. Accordingly, a total of 120 soil samples (60 for C content and 60 for bulk density) were collected and taken to laboratory for the determination of C content and BD. Walkley-Black method was used to estimate soil C stock. Independent t –test was used to test for differences in soil C stocks at significant level of 0.05.Results: The findings of the present study revealed that significantly higher soil C stock was recorded for PNF (136.2 + 8.42 t C ha-1) than FWC (90.76 + 4.97 t C ha-1) (p<0.05).Conclusion: The study concluded that conversion of natural forest to coffee-based forest leads to a reduction of SOC by 33.4%, which is equivalent to the emission of about 166.613 t CO2 ha-1 to the atmosphere. Thus, maintaining and enhancing the soil carbon sequestration potential of this forest soil should be required through implementation of different conservation mechanisms.
Co-designing a service specification for a pharmacogenomic testing service in community pharmacy in England
Authors: Rendell Tim , Barnett Julie , Scott Sion , Wright David 
Published: June 2022

Abstract
Introduction: Pharmacogenomics is a novel arena of medicine that uses patients’ DNA to support pharmacists and prescribers selecting the most appropriate medicine for patients.Aim: To use an online consensus panel to review and validate a service specification for a PGx testing service in the English community pharmacy setting.Method: A consensus panel comprising of pharmacists, prescribers and patients was convened to participate in a co-design process of critical comment, reviewing the operationalisation of Behaviour Change Techniques identified in a previous study. Panel members completed a survey prior to attending a workshop to discuss, agree and confirm the content for a service specification. Following the workshop recommended strategies for operationalisation were extracted and informed a final version of the service specification.Results: From the consensus panel, strategies for operationalisation of the Behaviour Change Techniques were identified including a pre-launch engagement event, subject matter expert support for healthcare professionals, provision of supporting materials and training requirements for clinical decision making. These were all incorporated into the service specification as part of the co-design.Conclusion: Designing a community pharmacy led pharmacogenomic service using co-design methodology has resulted in critical feedback, ideas validation and operationalisation of behavioural science generated Behaviour Change Techniques to develop a pragmatic service specification. This is more likely to result in both pharmacist engagement to offer and deliver a community pharmacist led pharmacogenomic testing service and prescriber acceptance of recommendations for any changes to patients’ prescriptions.
The Role of Reduced Glutathione on the Activity of Adenosine Deaminase, Antioxidative System, Aluminum and Zinc Levels in Experimental Aluminum Toxicity
Authors: ATAKISI Onur , DALGINLI Kezban YILDIZ , GULMEZ Canan , KALACAY Destan , ATAKISI Emine , ZHUMABAEVA Taasilkan TOKTAMAMATOVNA , AŞKAR Tunay KONTAŞ , DEMIRDOGEN Ruken Esra 
Published: June 2022

Abstract
Aluminum (Al) is the most common and widely used element in nature, which cause many health problems and toxic effects. The accumulation of aluminum in the brain, which easily crosses the blood-brain barrier, causes neurodegenerative diseases such as Alzheimer's and dementia, especially diseases associated with free radicals. Reduced glutathione (GSH) is an intracellular tripeptide with low molecular weight, hydrophilic properties, and strong antioxidant effects. This study aimed to investigate the role of reduced glutathione on the activity of adenosine deaminase, antioxidative system, aluminum and zinc levels in aluminum toxicity. In this study, Sprague Dawley rats (n=32) were used. The rats were divided into four equal groups. Group I received 0.5 mL intraperitoneal injection of 0.9 % saline solution (NaCI), Group II received single-dose AlCI3 , Group III was given GSH for seven days, Group IV was given AlCI3 single dose and at the same time 100 mg/kg GSH was given for seven days At the end of the experimental period of seven days, blood samples were collected by cardiac puncture. Plasma TAS and Zn levels were lower than the control group. In contrast, plasma TOS and aluminum concentrations and ADA activity were higher in the aluminum-administered group than in the control group. It was determined that the changed parameters returned to their normal levels in the group given GSH together with aluminum. As a result, additional GSH administration has a protective effect on adenosine deaminase activity, antioxidant system, and Zn level in experimental aluminum toxicity.
N-oleoylethanolamine Loaded Liposomes for Efficient Stroke Therapy
Authors: Wu Shichao , Yang Xiangrui 
Published: June 2022

Abstract
With high mortality, stroke has become a serious threat to human health. Nevertheless, the strategy for stroke therapy is quite limited in the clinic till now. In this research, we prepared a novel neuroprotective nanoformulation (OEA Liposomes) via encapsulating endogenous N-oleoylethanolamine (OEA) in liposomes for intravenous administration. The formulation largely increased the solubility and bioavailability of OEA. Then the following systematic experiments stated the excellent neuroprotective effect of OEA Liposomes in vivo. The survival rate of the nanodrug group was largely increased to 75%, while that of the MCAO group was only 41.7%. And the severe neurological functional deficit of the MCAO rats was also significantly improved. What’s more, the OEA Liposomes could inhibit the apoptosis of neurons and the inflammation of reperfusion to a very slight level, indicating their outstanding neuroprotective effect. These results indicated that the OEA Liposomes have a great potential for clinic anti-stroke application.
Use of a body-weight support device to train gait in a neurological intensive care unit. Safety, Feasibility, Time to independent walking
Authors: Jourdan Claire , Pradalier Fanny , Chalard Kevin , Ascher Margrit , Duran Francisco Miron , Pavillard Frédérique , Greco Frédéric , Mellouk Myriam , Fournier Stéphane , Djanikian Flora , Laffont Isabelle , Gelis Anthony , Perrigault Pierre-François 
Published: June 2022

Abstract
Background. Early Mobilization in Intensive Care Units (ICUs) enhances patients’ evolution, but its benefits and practical implementation have rarely been studied in neurological ICUs. To report on tolerance, feasibility and benefits of walking with a specific body-weight support (BWS) device for patients admitted to a neurological intensive care unit. Methods. Observational single-center one-year study. Inclusion criteria were adults with a neurological injury requiring mechanical ventilation. Exclusion criteria were early death or ICU transfer. After weaning from ventilation, patients were screened for indications of BWS walking using predefined criteria. Results. Patients’ conditions were mostly brain injuries: 32% subarachnoid hemorrhages, 42% focal strokes, 12% traumatic brain injuries. Out of 272 admissions, 136 patients were excluded, 78 were eligible, 33 performed BWS walking. Regarding non-eligible patients, 36 walked unsuspended upon ventilation weaning, 17 presented too severe impairments. Regarding the 45 eligible patients who did not receive BWS training, main reasons were workload and week-ends (31%), medical barriers (29%), early ICU discharge (22%). For the 33-patient study sample, 78 BWS sessions were performed. Pre-session, most patients had inadequate response to pain, orders, or simple orientation questions. Sitting without support was impossible for 74%. Most pre-post changes in hemodynamic, respiratory, and pain parameters were small. Eight sessions were interrupted; reasons were pain, fatigue or major imbalance (4), syncope (1), occurrence of stool (2), battery failure (1). All adverse events ended upon session interruption. Patients walked on median 17 meters. During 51% of sessions, patients showed a spontaneous smile. First BWS session occurred on median 3 days after ventilation weaning, and 11 days before patients were able to walk unsuspended. Conclusions. Verticalization and walking using a suspension device patients in neuroICU allows early gait training, despite challenging neurological impairments. It is safe and generally well tolerated. Trial registration. ClinicalTrials database (ID: NCT04300491)
Comparative non-invasive T1w/T2w myelin mapping of the night monkey: implications for cortical adaptation to a nocturnal niche environment
Authors: Ikeda Takuro , Autio Joonas A. , Kawasaki Akihiro , Takeda Chiho , Ose Takayuki , Takada Masahiko , Essen David Van , Glasser Matthew , Hayashi Takuya 
Published: June 2022

Abstract
Night monkeys (Aotus) are the only genus of monkeys within the Simian lineage that successfully occupy the nocturnal niche environment. Their behavior is supported by their sensory organs’ unique morphological features; however, little is known about their evolutionary adaptations in sensory regions of the cerebral cortex. Here, we investigate this question by exploring the cortical organization of night monkeys using high-resolution in-vivo brain MRI and comparative cortical-surface T1w/T2w myeloarchitectonic mapping. Our results show that the night monkey cerebral cortex has a similar organization of cortical myelin distribution compared to the diurnal macaque and marmoset monkeys. T1w/T2w myelin and its gradient allowed us to parcellate high myelin areas, middle temporal complex (MT + MST) and auditory cortex, and low myelin area, Brodmann area 7 (BA7) in three species, despite the difference in gyrifications. Relative to the total cortical surface area, those of MT + MST and the auditory cortex are significantly larger in night monkeys than diurnal monkeys. In contrast, the relative area of BA7 is expanded in proportion to brain size across species. We propose that the selective expansion of sensory areas dedicated to visual motion and auditory processing in night monkeys may reflect cortical adaptations to the nocturnal niche environment.
Construction of Prognostic Signature of Breast Cancer Based on N7-Methylguanosine-Related LncRNAs and Prediction of Immune Response
Authors: Cao Jin , Wang Buhai , Liang Yichen , Gu J. Juan , Huang Yuxiang 
Published: June 2022

Abstract
Background: N7-Methylguanosine (m7G) plays an important role in the occurrence and development of tumors, and long non-coding RNA (LncRNA) is a prognostic factor for tumors. However, the predictive value of m7G-related LncRNAs in breast cancer (BC) has not been reported. The purpose of this study is to construct a predictive signature based on m7G-related long non-coding RNAs (LncRNAs) to predict the prognosis of patients with breast cancer.Methods: We obtained the RNA-seq data and corresponding clinical data of breast cancer patients from the Cancer Genome Atlas (TCGA) database. We used co-expression network analysis, least absolute shrinkage selection operator (LASSO) regression analysis, univariate Cox regression analysis, and multivariate Cox regression analysis to screen N7-Methylguanosine-Related LncRNAs signature and construct a prognostic model. Kaplan-Meier analysis and Receiver Operating Characteristic (ROC) curve were used to evaluate the signature. Principal component analysis (PCA) and nomogram were used to verify the value of the prognostic signature. Subsequently, we used gene set enrichment analysis (GSEA) for functional analysis, single-sample gene set enrichment analysis (ssGSEA) to explore the relationship between predictive characteristics and tumor immune microenvironment in high-risk and low-risk groups, and compared the drug sensitivity between the two risk groups.Results: We constructed a signature consisting of nine m7G-related LncRNAs (LINC01871, AP003469.4, Z68871.1, AC245297.3, EGOT, TFAP2A-AS1, AL136531.1, SEMA3B-AS1, AL606834.2), which are independently related to the overall survival time (OS) of BC patients. The area under the ROC curve (AUC) for predicting 1-, 3-, and 5-year survival rates was 0.715, 0.724, and 0.726. Kaplan-Meier analysis showed that BC patients in the high-risk group had a poorer prognosis than patients in the low-risk group. Multiple regression analysis showed that risk score was a significant independent prognostic factor for BC patients, and was significantly better than clinicopathological features. SsGSEA analysis showed that the predictive characteristics were significantly correlated with the immune status of BC patients. The immune function of low-risk BC patients was more active, and low-risk patients were more sensitive to PD1/L1 immunotherapy.Conclusions: This prognostic signature based on m7G-related LncRNAs can independently predict the prognosis and immunotherapy response of patients with BC and can be used to guide the individualized treatment of breast cancer patients.