bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of Treatment of Acute Major Depressive Episodes in Bipolar I Versus Bipolar II Disorders With Quetiapine
Authors: Miola Alessandro , Tondo Leonardo , Baldessarini Ross J. 
Published: September 2022

Abstract

Background
Several second-generation antipsychotic drugs (SGAs) have evidence of benefit for acute major depressive episodes in bipolar disorder (BD) patients. However, their comparative efficacy in types I vs II BD (BD1 vs BD2) remains uncertain.

Methods
We carried out a systematic literature search for randomized, double-blinded, controlled treatment trials for acute major depressive episodes involving head-to-head comparisons of BD1 versus BD2 subjects, followed by meta-analyses and meta-regression modeling.

Results
Seven reports met out inclusion criteria, yielding 22 comparisons of SGA versus placebo averaging 8.3 weeks in duration. All trials involved quetiapine, which was much more effective than placebo (pooled standardized mean difference [SMD] = 1.76 [95% confidence interval, 1.40–2.12], P < 0.0001). Estimated % improvement averaged 53.5% [46.5–60.5] with quetiapine vs 39.8% [34.2–45.4] with placebo (P < 0.0001); their ratio was somewhat larger with BD1 (1.56 [1.26–1.86]) versus BD2 subjects (1.22 [1.07–1.37], P = 0.04; as was SMD (BD1: 2.35 [1.83–2.86]; BD2: SMD = 1.44 [1.05–1.82]). Meta-regression found diagnosis (BD1 > BD2) to be the only factor significantly associated with the meta-analytic outcome.

Conclusions
Although data are limited, depressed BD1 patients may respond somewhat better to quetiapine than BD2. Additional head-to-head diagnostic comparisons are needed with other SGAs, as well as evaluation of monotherapy versus various combinations that include SGAs in both short- and long-term use.
Factors Associated With Follow-Up Visits in Parents With Myopic Children Wearing Orthokeratology Lens
Authors: HUNG Li-Ling , LIAO Li-Ling , CHEN Hsiao-Jung , LIN Hui-Ling , CHANG Li-Chun 
Published: September 2022

ABSTRACT

Background
Orthokeratology (Ortho-k) is an effective method for slowing the progression of myopia and correcting refractive error in school children. Although parents of children aged < 10 years play a major role in Ortho-k lens care, they have a generally low level of compliance in performing regular follow-up visits.

Purpose
This study was developed to analyze the associations between follow-up visits by parents of Ortho-k lens wearers aged < 10 years and, respectively, the Ortho-k-related knowledge of these parents and information resources promoting Ortho-k use.

Methods
A cross-sectional study design was used. Parents of children who wear Ortho-k lenses were recruited through a private Facebook group with 3,500 members in 2020 that was created in 2018 for information sharing and exchange among parents of these children. The following data were collected: demographics of the parents and their children, four-item Ortho-k-related knowledge, information resources that prompted the decision to use Ortho-k, and the regularity of follow-up visits. These data were presented in terms of means, standard deviations, and percentages. Logistic regression was performed to compute the odds ratios (ORs) and 95% confidence intervals (CIs).

Results
The study showed that 83.11% had regular follow-up visits. The correct response rate on Ortho-k-related knowledge was > 80%. However, 15.51% of the participants did not recognize axial length as an indicator for monitoring myopia progress, and 10.76% did not know that at least 6 hours of nighttime sleep is required for myopia control with Ortho-k. The most common information resource leading to Ortho-k use was self-acquisition from Internet sources. The spherical equivalent refraction of < −2.0 D was 2.58 times higher in participants with regular follow-up visits than in their peers with irregular follow-up visits (OR = 2.58, 95% CI [0.22, 5.63]). In addition, acknowledgment of “There is no need to change the Ortho-k lenses regularly as long as there is no discomfort” was 7.19 times higher in participants with regular follow-up visits than in their peers with irregular follow-up visits (OR = 7.19, 95% CI [1.26, 13.93]). However, participants with regular follow-up visits did not receive Internet ophthalmology advertisements prompting their decision to use Ortho-k 2.62 times higher than their peers with irregular follow-up visits (OR = 2.62, 95% CI [0.04, 4.29]).

Conclusions
The results support that both information sources and knowledge of Ortho-k use influence the frequency of follow-up visits among parents of Ortho-k lens wearers aged < 10 years. Related support from health professionals in terms of providing appropriate information and guidance is recommended to promote higher rates of regular follow-up visit attendance.
The Effect of Buzzy Application on Pain Level During Vaccine Injection in Infants
Authors: Şıktaş Özge , Uysal Gülzade 
Published: September 2022

Background:
Nonpharmacological interventions are needed to reduce pain during vaccine administration in infants.

Purpose:
To determine the effect of the Buzzy device, which is a combination of cold and vibration, on pain during measles-mumps-rubella (MMR) vaccine administration in 12-month-old infants.

Methods:
A prospective randomized controlled experimental research design was used.

Results:
A total of 60 infants were included in the study. During and after vaccine injection, pain scores of infants who had the Buzzy device were significantly lower than those of infants in the control group (P = .001).

Conclusions:
Buzzy application may be an effective method in reducing pain during MMR vaccine administration. Use of the device is recommended for infants receiving vaccinations.
Engaging Students and Faculty in a Collaborative Learning Environment
Authors: Marquez Beth , Gannon Marianne E. , Rocafort Terri 
Published: September 2022

Background:
The increasing move to distance education has exposed gaps in the implementation and sustainability of collaborative learning. Collaborative learning requires a mutual approach to knowledge building, which includes both students and faculty.

Purpose:
This quality improvement pilot focused on providing additional socialization and collaborative learning in an asynchronous environment.

Methods:
A review of the literature identified opportunities to address the social and academic needs of students pursuing an online degree, along with strategies to address feelings of isolation experienced by some students in a distance learning environment. The Let's Check-In: Tips for Success webinars were developed and integrated throughout the graduate curriculum.

Results:
Students provided positive feedback verbally and in end-of-course evaluations. Course faculty reported a more synergistic approach to teaching.

Conclusion:

Let's Check-In: Tips for Success provided an environment where student communication and understanding of course content increased.
Correction of Presbyopia Alone Does Not Adequately Protect against Digital Eye Strain from Handheld Devices
Authors: Mylona Ioanna , Floros Georgios D. 
Published: September 2022

SIGNIFICANCE
The use of screen-enabled handheld devices has increased exponentially during the last few years among the older adults. Up until now, a general suggestion for preventing symptoms of digital eye strain with large screen use was to address any existing refractive error, including presbyopia. It is unclear whether this advice is of consequence in the case of smaller handheld devices.

PURPOSE
The aim of this study was to examine whether correcting presbyopia ameliorates the negative effect on digital screen use, examining handheld devices where these issues are expected to be more acute with presbyopic individuals.

METHODS
This is a cross-sectional study of 120 consecutive participants who had received correction for presbyopia during the past month and returned for a routine follow-up examination. The participants filled in a demographics questionnaire, questions on time spent online and using devices with digital screens, data on their eye complaints, and the validated Digital Eye Strain Questionnaire (DESQ).

RESULTS
The DESQ factor scores and total score correlated with the near addition (P < .001). Higher DESQ scores were associated (by order of magnitude) with higher near addition and a lower amount of time spent using a handheld screen-enabled device (P < .001) while controlling for age and type of corrective lenses.

CONCLUSIONS
Results indicate that older adults are at an additional disadvantage while using handheld screen-enabled devices compared with younger adults: they are more likely to be presbyopes and need higher near addition, yet increasing near addition does not guarantee greater comfort in the use of smartphones but rather increase the likelihood of experiencing digital eye strain symptoms.
Telerehabilitation Training to Facilitate Improved Reading Ability with New Magnification Devices for Low Vision
Authors: Bittner Ava Katherine , Kaminski John E. , Ross Nicole C. , Shepherd John D. , Thoene Stacy J. , Bui Sarah Z. , Yoshinaga Patrick D. ,   for the BeST-AID Study Team
Published: September 2022

SIGNIFICANCE
This pilot study provides some insight about the potential benefits of telerehabilitation training to improve the reading ability of adults with low vision using magnifiers, to spur future work with larger groups. Telerehabilitation services can be implemented clinically to facilitate access to follow-up care for low vision.

PURPOSE
A recent Cochrane systematic review revealed that there are no published visual function outcomes for telerehabilitation with handheld magnification devices for low vision; thus, this study aimed to provide evidence for its preliminary efficacy.

METHODS
One to 4 months after receiving a new magnification device (i.e., handheld or stand optical magnifier or portable electronic magnifier), 14 adult low vision patients (with any visual acuity level or ocular diagnosis) received two training sessions at home via telerehabilitation with their vision rehabilitation provider located remotely in-office. Telerehabilitation included a loaner smartphone for Zoom videoconferencing with remote control access software. The Minnesota Low-Vision Reading Test was administered during each of the telerehabilitation sessions to assess near reading (acuity and speed) with the new magnifier.

RESULTS
Mean reading acuity with the magnifier was 0.17 logMAR across subjects before training at telerehabilitation session 1, which significantly improved to 0.09 on average a few weeks later at telerehabilitation session 2 (95%confidence interval, −0.001 to −0.16; P = .047). Logarithm reading speed with the magnifier for the reading acuity level at session 1 improved significantly by 0.18 log words per minute on average for the same text size at session 2 (95% confidence interval, 0.06 to 0.29; P = .002). With the magnifier at session 2, 71% of participants gained at least 0.1 log unit in reading acuity, and half improved by >0.01 in log reading speed; all participants with increased reading speed also improved in reading acuity (P = .02).

CONCLUSIONS
These preliminary data support that telerehabilitation can enhance reading ability and efficiency with newly prescribed magnifiers as an alternative option to in-office vision rehabilitation.
Adolescent Substance Use Disorder Diagnosis Correlates With Hospitalization After an Emergency Department Visit
Authors: Thurstone Christian , Loh Ryan , Piatz Christopher , Simpson Scott A. 
Published: September 2022

Introduction
The purpose of this study is to compare the prevalence of hospitalization after an emergency department (ED) visit at an urban safety net hospital for youth with and without a substance use disorder.

Methods
This study used a retrospective cohort design of adolescents (aged 15–21 y; n = 14,852) treated in the ED and compared the risk of hospitalization within 90 days.

Results
A substance use disorder diagnosis in the ED more than doubled the risk of 90-day hospitalization (5.4% vs 2.38%; P < 0.0001).

Conclusions
Compared with youth without a substance use disorder, youth with substance use disorders are likely to require additional services after an ED visit.
Fractionated brain irradiation profoundly reduces hippocampal immature neuron numbers without affecting spontaneous behavior and cognition in mice
Authors: Kuil L.E. , Seigers R. , Loos M. , de Gooijer M.C. , Compter A. , Boogerd W. , Van Tellingen O. , Smit A.B. , Schagen S.B. 
Published: September 2022

AbstractWhole brain radiotherapy (WBRT) is used to treat patients with primary brain tumors, or brain metastasis from various primary tumors to improve tumor control. However, WBRT can lead to cognitive decline. We treated mice with fractionated WBRT (fWBRT) to establish a model system to study the mechanisms underlying cognitive decline. Besides a series of traditional cognitive tests, we also assessed the effect on spontaneous behavior as measured in automated home cages.Male C57Bl/6j mice (n=11 per group) received bi-lateral fWBRT at a dosage of 4 Gy/day on 5 consecutive days. In line with previous reports, immunohistochemical analysis of doublecortin (DCX) positive cells in the dentate gyrus showed a profound reduction in immature neurons at 4 weeks after fWBRT. Surprisingly, spontaneous behavior as measured in automated home cages was not affected. Moreover, learning and memory measured with traditional tasks - including the novel object recognition task, novel location recognition task, Barnes maze, and fear conditioning - was also not affected at 4-6 weeks after fWBRT. At 10-11 weeks after fWBRT a difference in escape latency during the learning phase, but not in the probe phase of the Barnes maze was observed.In conclusion, although we confirmed the effect of fWBRT on neurogenesis at 4 weeks after fWBRT, we did not find clear effects on spontaneous behavior in the automated home cage nor on learning abilities as measured by traditional cognitive tasks. The relationship between the neurobiological effects of fWBRT and cognition seems more complex than often assumed and the choice of animal model, cognitive tasks, neurobiological parameters, and experimental set-up might be important factors in these types of experiments.
Resting EEG power spectra across middle to late life: Associations with age, cognition, APOE-ε4 carriage and cardiometabolic burden
Authors: Smith Ashleigh E. , Chau Anson , Greaves Danielle , Keage Hannah A.D. , Feuerriegel Daniel 
Published: September 2022

AbstractWe investigated how resting EEG measures are associated with risk factors for late-life cognitive impairment and dementia, including age, Apolipoprotein E ε4 (APOE-ε4) carriage and cardiometabolic burden. Resting EEG was recorded from 86 adults (50-80 years of age). Participants additionally completed the Addenbrooke’s Cognitive Examination (ACE) III and had blood drawn to assess APOE-ε4 carriage status and cardiometabolic burden. EEG power spectra were decomposed into sources of periodic and aperiodic activity to derive measures of aperiodic component slope and alpha (7-14 Hz) and beta (15-30 Hz) peak power and peak frequency. Alpha and beta peak power measures were corrected for aperiodic activity. The aperiodic component slope was correlated with ACE-III scores but not age. Alpha peak frequency decreased with age. Individuals with higher cardiometabolic burden had lower alpha peak frequencies and lower beta peak power. APOE-ε4 carriers had lower beta peak frequencies. Our findings suggest that the slope of the aperiodic component of resting EEG power spectra is more closely associated with measures of cognitive performance rather than chronological age in older adults.
Senescence-induced cellular reprogramming drives cnidarian whole-body regeneration
Authors: Salinas-Saavedra Miguel , Febrimarsa  , Krasovec Gabriel , Horkan Helen R , Baxevanis Andreas D , Frank Uri 
Published: September 2022

SUMMARYCell fate stability is essential to maintaining ‘law and order’ in complex animals. However, high stability comes at the cost of reduced plasticity and, by extension, poor regenerative ability. This evolutionary trade-off has resulted in most modern animals being rather simple and regenerative or complex and non-regenerative. The mechanisms mediating cellular plasticity and allowing for regeneration remain unknown. We show that signals emitted by senescent cells can destabilize the differentiated state of neighboring somatic cells, reprogramming them into stem cells that are capable of driving whole-body regeneration in the cnidarian Hydractinia symbiolongicarpus. Pharmacological or genetic inhibition of senescence prevented reprogramming and regeneration. Conversely, induction of transient ectopic senescence in a regenerative context resulted in supernumerary stem cells and faster regeneration. We propose that senescence signaling is an ancient mechanism mediating cellular plasticity. Understanding the senescence environment that promotes cellular reprogramming could provide a new avenue to enhance regeneration.
Gene Expression Profiles Reveal Potential Targets for Breast Cancer Diagnosis and Treatment
Authors: Nasirpour Mohammad Hossein , Sabery Anvar Mohammad , Alireza Nasirpour , Mahdieh Salimi , Soheil Sepahyar , Zarrin Minuchehr 
Published: September 2022

AbstractFiguring out the molecular mechanisms underlying breast cancer is essential for the diagnosis and treatment of this invasive disorder. Hence it is important to identify the most significant genes correlated with molecular events and to study their interactions in order to identify breast cancer mechanisms. Here we focus on the gene expression profiles, which we have detected in breast cancer. High-throughput genomic innovations such as microarray have helped us understand the complex dynamics of multisystem diseases such as diabetes and cancer. We performed an analysis using microarray datasets by the Networkanalyst bioinformatics tool, based on a random effect model (REM). We achieved pivotal differential expressed genes like ADAMTS5, SCARA5, IGSF10, and C2orf40 that had the most down-regulation, and also COL10A1, COL11A1, and UHRF1 that they had the most up-regulation in four-stage of breast cancer. We used CentiScape and AllegroMCODE plugins in CytoScape software in order to figure out hub genes in the protein-protein interactions network. Besides, we utilized DAVID online software to find involved biological pathways and Gene ontology, also used Expression2kinase software in order to find upstream regulatory transcription factors and kinases. In conclusion, we have found that the statistical network inference approach is useful in gene prioritization and is capable of contributing to practical network signature discovery and providing insights into the mechanisms relevant to the disease. Our research has also identified novel transcription factors, kinases, pathways, and genes that may serve as important targets for the development of diagnostic biomarkers and treatments.
Cryogenic X-ray crystallographic studies of biomacromolecules at Turkish Light Source “Turkish DeLight”
Authors: Atalay Necati , Akcan Enver Kamil , Gül Mehmet , Ayan Esra , Destan Ebru , Ertem Fatma Betül , Tokay Nurettin , Çakilkaya Barış , Nergiz Zeliş , Karakadioğlu Gözde , Kepceoğlu Abdullah , Yapici İlkin , Tosun Bilge , Baldir Nilüfer , Yildirim Günseli , Johnson J Austin , Güven Ömür , Shafiei Alaleh , Arslan Nazlı Eylül , Yilmaz Merve , Kulakman Cahine , Paydos Seyide Seda , Çinal Zeynep Sena , Şabanoğlu Kardelen , Pazarçeviren Ayşegül , Yilmaz Ayşenur , Canbay Başak , Aşci Bengisu , Kartal Esra , Tavli Serra , Çaliseki Mehmet , Göç Günce , Mermer Arif , Yeşilay Gamze , Altuntaş Sevde , Tateishi Hiroshi , Otsuka Masami , Fujita Mikako , Tekin Şaban , Çiftçi Halilibrahim , Durdaği Serdar , Dinler Doğanay Gizem , Karaca Ezgi , Kaplan Türköz Burcu , Kabasakal Burak Veli , Kati Ahmet , Demirci Hasan 
Published: September 2022

AbstractX-ray crystallography is a robust and powerful structural biology technique that provides high-resolution atomic structures of biomacromolecules. Scientists use this technique to unravel mechanistic and structural details of biological macromolecules (e.g. proteins, nucleic acids, protein complexes, protein-nucleic acid complexes, or large biological compartments). Since its inception, single-crystal cryo-crystallography has never been performed in Türkiye due to the lack of a single-crystal X-ray diffractometer. The X-ray diffraction facility recently established at the University of Health Sciences, Istanbul, Türkiye will enable Turkish and international researchers to easily perform high-resolution structural analysis of biomacromolecules from single crystals. Here, we describe the technical and practical outlook of a state-of-the-art home-source X-ray, using lysozyme as a model protein. The methods and practice described in this article can be applied to any biological sample for structural studies. Therefore, this article will be a valuable practical guide from sample preparation to data analysis.
Expanded utility of the R package qgg with applications within genomic medicine
Authors: Rohde Palle Duun , Sørensen Izel Fourie , Sørensen Peter 
Published: September 2022

AbstractSummaryHere, we present an expanded utility of the R package qgg for quantitative genetic and genomic analyses of complex traits and diseases. One of the major updates of the package is, that it now includes five different Bayesian Linear Regression (BLR) models, which provide a unified framework for mapping of genetic variants, estimation of heritability and genomic prediction from either individual level data or from genome-wide association study (GWAS) summary statistics. To showcase some of the novel implementations, we analysed two quantitative trait phenotypes, body mass index and standing height from United Kingdom Biobank (UKB). We compared genomic prediction accuracies from single and multiple trait models, showed accurate estimation of genomic parameters, illustrate how a BLR model can be used to fine map potential causal loci, and finally, provide an extension of gene set enrichment analyses based on the BLR framework. With this release, the qgg package now provides a wealth of the commonly used methods in analysis of complex traits and diseases, without the need to switch between software tools and data formats.AvailabilityOur methodology is implemented in the publicly available R software package qgg using fast and memory efficient algorithms in C++ and is available from CRAN or as a developer version at our GitHub page (https://github.com/psoerensen/qgg). Notes on the implemented statistical genetic models, tutorials and example scripts are available from our accompanied homepage https://qganalytics.com/.Contactpalledr@hst.aau.dk and pso@qgg.au.dkSupplementary informationSupplementary data are available online.