bluuebunny/crossref_metadata_2025_split huggingface dataset:
Personality-dependent nest site selection and nest success during incubation in a wild population of chestnut thrush Turdus rubrocanus
Authors: Lou Yingqiang , Zhao Qingshan , Hu Yunbiao , Chen Lijun , Liu Pengfei , Fang Yun , Lloyd Huw , Sun Yuehua 
Published: September 2022

Abstract
Within the same species population, individuals with different personality traits may choose different habitats, which could result in different reproductive fitness. In birds, little is known about how individuals respond to nest site selection basing on their personality traits. Here, we address this knowledge gap and investigate whether an individual’s personality (activity and breathing rate) can affect patterns of nest site selection at different spatial scales in a wild population of chestnut thrush (Turdus rubrocanus) and determine whether nest site characteristics and female personality traits affect clutch size and nest success during incubation. We found that neither activity nor breathing rate was associated with large-scale nesting habitat variables. At the fine-scale level, more active females chose nest sites with greater nest lateral concealment, whereas females with lower breathing rate chose nest sites with lower concealment above the nest. Females with higher breathing rates laid smaller clutch sizes than individuals with lower breathing rate. Nests with greater vegetation concealment above nests and females with lower breathing rate had higher nest success during incubation. This work highlights the importance of understanding the relationships between personality and nest site selection in birds, and the role of female personality traits in reproductive success.
Construction of a macula-specific lncRNA-miRNA-mRNA network in age- related macular degeneration patients
Authors: Chen Sainan , Chen Yuqing , Yue Zifan , Diao Jiale , Tong Fei , Wei Ruili 
Published: September 2022

Abstract
Background:Age-related macular degeneration (AMD) is the primary cause of visual impairment among the elderly. It mainly affects the macular region of the fundus oculi. Studies have shown that macular and extramacular region's gene expression differs considerably. This may be the reason for regional specificity and different phenotypic outcomes of the AMD. The non-coding RNA (ncRNAs) is a RNAs that cannot encode proteins in the human transcribed genome. However, they are involved in many life events as regulatory molecules. NcRNAs were identified to play a vital role in AMD. But the molecular mechanism underlying ncRNAs in AMD remains unclear. In the current study, we explored the differences in the macular and extramacular regions of the retina gene expression in AMD patients. We investigated the function of ncRNAs by constructing the lncRNA-miRNA-mRNA network.Results:A total of 4491 DE-mRNAs and 18 DE-lncRNAs were discovered in the macular and the retina region of the retina of AMD patients. In the lncRNA-miRNA-mRNA network, 18 lncRNAs, 41 miRNAs, and 404 mRNAs were established through target gene prediction. Co-expression analysis showed that 51 pairs of lncRNAs and mRNAs in the lncRNA-miRNA-mRNA network had a positive co-expression. GO and KEGG pathway analysis indicated that mRNAs involved in the lncRNA-miRNA-mRNA network were mainly enriched in the apoptotic signaling pathway, negative regulation of nitrogen compound metabolic process, cellular response to chemical stimulus, and MAPK signaling pathway, endocytosis, PI3K-Akt signaling pathway, cellular senescence, hepatitis, axon guidance, microRNAs in cancer, mTOR signaling pathway, AMPK signaling pathway, and longevity regulating pathway. In addition, DO enrichment indicated that 18 DE-lncRNAs were enriched in 266 diseases.Conclusions:In this study, we constructed the lncRNA-miRNA-mRNA network consisting of 18 lncRNAs, 41 miRNAs, and 404 mRNAs. In addition, 51 pairs of lncRNAs and mRNAs presented a positive co-expression relationship.
An analysis of prevalence, disability-adjusted life years of asthma in China: results from the GBD Study 2019 of the G20
Authors: Liu Mingtao , Gan Hui , Lin Yilu , Lin Runpei , Xue Mingshan , Zhang Teng , Cheng Zhangkai J. , Sun Baoqing 
Published: September 2022

AbstractBackground The credible materials about the burden of asthma in China compared to the others in the Group of Twenty (G20) remains unavailable. Methods Following the popular analysis strategy used in the Global Burden of Disease Study, the age-, sex-, country-specific prevalence, and disability-adjusted life years (DALYs) of asthma in China were analyzed. Meanwhile, the comparison in trends between China and other countries in the G20 was also evaluated. Results In 2019, asthma was the 8th leading cause of the DALYs burden of 369 diseases in China. From 1990 to 2019, the age-standardized prevalence and DALYs rates of asthma in China decreased by 14% and 51%, respectively, and the decline rate of DALYs was much higher than the global average (-51%: -43%). It is worth noting that the overall population age-standardized DALYs rate of asthma in China was the lowest in the G20 during 2019 (102.81, 95%UI: (72.30,147.42)/100,000). Moreover, the age-standardized asthma prevalence rate peak in both childhood (178.14, 95%UI: (90.50, 329.01)/100,000) and the elderly (541.80, 95%UI: (397.79, 679.92)/100,000), with subjects in the 5–9 years old interval being a constant focus of our attention. Conclusions The disease burden of asthma varied greatly by gender and age over the past 30 years. In contrast to increasing burden in most other G20 countries, the age-standardized prevalence rate of asthma shows a significant decreasing trend in China, however, the age-standardized DALYs rate shows a fluctuating change, and even shows a rebound trend in recent years.
Impact of small for gestational age infants by updated local curve on neonatal mortality in Indonesia
Authors: Haksari Ekawaty L. , Hakimi Mohammad , Ismail Djauhar 
Published: September 2022

Abstract

ObjectivesTo study early neonatal and neonatal mortality of small for gestational age (SGA) infants using the updated newborn curveMethodsA retrospective cohort study on all live births was conducted in Sleman and Sardjito hospital, Yogyakarta. Analysis was made with Kaplan-Meier, multivariate with Cox Hazard, and Population Attributable Risk (PAR). ResultThere were 35,649 live births eligible for the study. Early neonatal death by gestational age using the analysis of Kaplan Meier revealed the highest cumulative mortality incident (CMI) in preterm SGA. Respiratory distress was the highest risk with Hazard ratio (HR) 9.46, followed by asphyxia with HR 5.08, mother’s death with HR 2.27, extra-health facility with HR 1.97, Symmetrical SGA with HR 1.97, preterm appropriate gestational age (AGA) with HR 1.75, low birth weight (LBW) with HR 1.64, primary health facility with HR 1.33 and boys with HR 1.16 consecutively. Similar result was found in the neonatal mortality.Estimated highest PAR of early neonatal mortality in LBW SGA was 11.98, while LBW AGA was 6.07, whereas by gestational age the highest was in gestational age <28 weeks with PAR 25.13, followed by premature babies whose value decreased as their the gestational age increased. Similar result was identified in neonatal mortalityConclusionLocal updated newborn curve based on gestational age of early neonatal and neonatal mortality showed the highest CMI in preterm SGA. Estimated highest PAR in early neonatal and neonatal mortality was found in LBW SGA and preterm infants.
A nomogram for predicting the risk of pulmonary fungal infection for patients with pulmonary tuberculosis
Authors: Yan Hongxuan , Guo Li , Pang Yu , Liu Fangchao , Liu Tianhui , Gao Mengqiu 
Published: September 2022

Abstract
Background: Pulmonary fungal infection is one of the common complications in patients with pulmonary tuberculosis(PTB).The aim of this study was to construct a nomogram to predict the risk of pulmonary fungal infection in patients with PTB.Methods: The present case control study retrospectively collected materials of 286 patients affected by PTB and received treatment from 2016.12.6-2021.12.6, in Beijing Chest Hospital, Capital Medical University. As control subjects, patients with sex and address corresponding to those of the case subjects were included in the study at a proportion of 1 controls for every case subject. These 286 patients were randomly divided into a training set and an internal validation set at a ratio of 3:1.Chi-square test and logistic regression analysis were performed in the training set, and a nomogram was developed using selected predictors. Then a bootstrapping procedure was used for internal validation.Results: Seven variables [illness course, pulmonary avitation, advanced antibiotics were used for at lest 1 week, chemotherapy or immunosuppressants, surgery, bacterial infection in the lungs, hypoproteinemia] were finally validated and used to develop a nomogram. The nomogram showed good discrimination capability for both training set[area under the curve (AUC) =0.860, 95% confidence interval (CI) = 0.811–0.909] and internal validation set(AUC =0.884, 95% CI = 0.799–0.970). Its calibration curves also showed that the probabilities as predicted by the nomogram displayed a satisfied consistence with the actual probability for both training set and internal validation set.Conclusions: We developed a nomogram that can predict the risk of pulmonary fungal infection in patients with PTB. It showed potential clinical utility.
Internal states as a source of subject-dependent movement variability and their representation by large-scale networks
Authors: Breault Macauley , Sacre Pierre , Fitzgerald Zachary , Gale John , Cullen Kathleen , Gonzalez-Martinez Jorge , Sarma Sridevi 
Published: September 2022

Abstract
A human's ability to adapt and learn relies on reflecting on past performance. Such reflections form latent factors called internal states that induce variability of movement and behavior to improve performance. Internal states are critical for survival, yet their temporal dynamics and neural substrates are less understood. Here, we link internal states with motor performance and neural activity using state-space models and local field potentials captured from depth electrodes in over 100 brain regions. Ten human subjects performed a goal-directed center-out reaching task with perturbations applied to random trials, causing subjects to fail goals and reflect on their performance. Using computational methods, we identified two internal states, indicating that subjects kept track of past errors and perturbations, that predicted variability in reaction times and speed errors. These states granted access to latent information indicative of how subjects strategize learning from trial history, impacting their overall performance. We further found that large-scale brain networks differentially encoded these internal states. The dorsal attention network encoded past errors in frequencies above 100 Hz, suggesting a role in modulating attention based on tracking recent performance in working memory. The default network encoded past perturbations in frequencies below 15 Hz, suggesting a role in achieving robust performance in an uncertain environment. Moreover, these networks more strongly encoded internal states and were more functionally connected in higher performing subjects, whose learning strategy was to respond by countering with behavior that opposed accumulating error. Taken together, our findings suggest large-scale brain networks as a neural basis of strategy. These networks regulate movement variability, through internal states, to improve motor performance.
Second and Third Line Treatment Strategies in Multiple Myeloma: a Referral-Center Experience
Authors: Goldman-Mazur Sarah , Visram Alissa , Rajkumar S , Kapoor Prashant , Dispenzieri Angela , Lacy Martha , Gertz Morie , Buadi Francis , HAYMAN Suzanne , Dingli David , Kourelis Taxiarchis , Gonsalves Wilson , Warsame Rahma , Muchtar Eli , Leung Nelson , KYLE Robert , Kumar Shaji 
Published: September 2022

Abstract
The treatment landscape for relapsed multiple myeloma (MM) has increased. In this study we aimed to characterize 2nd (n = 1439) and 3rd (n = 1104) line regimens and compare the results between subgroups based on the year of treatment initiation (2nd line: 2003–2008, 2009–2015, 2016–2021; 3rd line: 2004–2009, 2010–2015, and 2016–2021). In both 2nd and 3rd line we observed increasing use of novel agents (from 78–95% and from 77–95%, respectively) and triplet regimens (from 15–69% and from 21–71%, respectively). Most frequently used regimens in the last studied periods included lenalidomide-dexamethasone (RD; 14%), carfilzomib-RD (12%) and daratumumab-RD (10%) for 2nd line, and daratumumab-pomalidomide-dexamethasone (11%) and daratumumab-RD (10%) for 3rd line. Median time to next treatment from 2nd line therapy has improved from 10.4 months (95% CI 8.4–12.4) to 16.6 months (95% CI 13.3–20.3; p < 0.001). The median overall survival from 1st relapse increased from 30.9 months (95% CI 26.8–183.0) to 65.8 months (95% CI 50.7–72.8; p < 0.001). Over the last two decades more patients were treated with newer agents and triplets for relapsed MM. The landscape of regimens has become more diverse, and the survival after 1st relapse is continually improving.
Rigidity dependent formation process of DNA supramolecular hydrogel
Authors: Liu Dongsheng , Pan Yufan , Yang Bo , Xu Rui , Li Xin , Dong Yuanchen 
Published: September 2022

Abstract
A DNA building block with tunable rigidity was constructed and the hydrogel formation process has been investigated accordingly. The high rigidity has been demonstrated to facilitate the fast gelation. Different pathways were revealed between the rigid and flexible building block and a cyclized dimer intermediate has been proposed. The energy barrier of the ring open process has also been proved to play a fundamental role in determining the gelation kinetics. Furthermore, the hydrogel molecular network rigidity was also tuned in situ through strand displacement, which also support the kinetic control mechanism in the formation process of DNA hydrogel.
Factors associated with the severity of premenstrual symptoms in women with central obesity: a cross sectional study
Authors: Sharifan Payam , Esfahani Ali Jafarzadeh , Zamiri Amir , Toosi Mansoureh Sadat Ekhteraee , Sedghdoost Fatemeh , Taghizadeh Niloufar , Mohammadi-Bajgiran Maryam , Ghazizadeh Hamideh , sahravard Toktam , Ferns Gordon , Ghayour-Mobarhan Majid 
Published: September 2022

Abstract
Introduction: Premenstrual syndrome (PMS) is a common condition that affects social and psychological well-being of women. The risk of PMS is higher among obese women. The aim of this study was to identify the factors that influence the severity of PMS in women with central obesity.Materials and methods: This cross-sectional study was performed on women who were 30 to 50-year-old with abdominal obesity (waist circumference > 80cm). The following data were collected: demographic data, anthropometric measurements, premenstrual symptoms screening tools (PSST), semi-quantitative food frequency questionnaire (FFQ), 42-item depression, anxiety, and stress questionnaire (DASS-42), as well as serum vitamin D, and renal function tests. Results: A total of 139 women (mean age of 41.40 ± 7.39 years old) participated in the study. The prevalence of mild, moderate and severe premenstrual symptom was 38.7% (55/142), 31.7% (45/142) and 27.5% (39/142), respectively. There was no significant difference between the groups in terms of anthropometric measurements and energy-adjusted nutrient intakes (p>0.05). There was a significant relationship between moderate PMS and energy-adjusted SFA (p=.018, OR=.010 and 95% CI for OR: <.001 and .452), and energy-adjusted riboflavin (p=.042, OR=.005, 95% CI for OR: <.001 and .821) and between severe PMS and age (p=.034, OR=.906, 95% CI for OR: .826 and .993), and energy-adjusted monounsaturated fatty acid (MUFA) intake (p=.041, OR=23.789, 95% CI for OR: 1.138 and 497.294). Conclusions: High intakes of MUFA and younger age were associated with a greater severity of PMS, while riboflavin intake was associated with reduced PMS severity.
Study on the inactivation effect and damage on bacteria of ultraviolet light with multi irradiance by UV-LED
Authors: Mengmeng Li , Baiqin Zhao , Lei Han , Zhen Wang 
Published: September 2022

Abstract
It is acknowledged that the inactivation of ultraviolet has been widely used in various fields. In this article, the dose differences of various pathogenic bacteria were compared and the influence of bacterial survival state on the sterilization effect were sorting out. The effective sterilization methods and the UV sterilization mechanism of the DNA structure were explored.
In the experiment, the ultraviolet (UV-C) lamp device with multi irradiance and regular irradiation was designed and assembled to carry out the irradiation experiment of bacteria. A variety of pathogenic bacteria were used in the unified culture environment and irradiation conditions, and the sterilization rate was calculated through the proliferation of bacteria after UV irradiation. The irradiation dose and dose curve of each strain to achieve the bactericidal rate were obtained. The penetration of UV to bacteria was evaluated through the killing effect of UV on colonies. The difference between bacteria and UV energy was discussed, and the influence of irradiance on inactivation effect was demonstrated.
Irradiance and irradiation dose play a decisive role in the efficacy of UV sterilization. The UV dose was positively correlated with the bactericidal rate, and the bactericidal rate increased with the increase of the dose. High dose UV irradiation can kill multilayer bacteria. In the detection of bacterial damage, the UV energy in the experiment did not break the DNA fragment into small molecular bands. The ultra microstructure diagram showed that UV irradiation made the linear DNA condense, and the abnormal DNA structure could not replicate and inherit. The application of ultraviolet sterilization has a suitable energy range.
How I do It: Knot Placement Technique for Self-Gripping Mesh in Totally Extraperitoneal (TEP) Inguinal Hernia Repair
Authors: Nassar Ricardo , Girón Felipe , Núñez-Rocha Ricardo E. , Rey Carlos Eduardo , Rodríguez Lina Marcela , Pérez Agustín , Latiff Mario , Hernández Juan David 
Published: September 2022

Abstract
Background
Surgical Inguinal hernia repair techniques are constantly evolving. Mesh fixation and placement remain cornerstones of the procedures. The use of self-gripping mesh has shown a significant reduction in postoperative pain and complications. However, technical difficulties arise, and multiple deployment methods have been described, with no consensus. Therefore, in this study, we present a novel preparation, deployment, and placement technique for self-gripping mesh during laparoscopic inguinal hernia repair, with its consequent outcomes and follow-up.
Methods
The self-gripping mesh is folded in half, non-absorbable sutures are placed in each distal portion and in the middle of the mesh, making sure the knot lies in the non-adherent surface. Corners are rounded. Mesh is rolled using the “tobacco technique”. The mesh is then placed with the laparoscopic grasper inside the preperitoneal cavity and is unrolled from medial to lateral.
Results
142 patients underwent totally extraperitoneal (TEP) inguinal hernia repair. Self-gripping mesh (ProgripTM) was used in all cases. 48.6% had bilateral defects. 33 patients underwent additional procedures. Mean time for mesh deployment was 180 seconds. Mean in-hospital stay was 1.6 days. No conversion was necessary. 88.9%, 86% and 36.7% of patients completed one year, 2 years, and 5 years of follow-up respectively. Chronic pain was present in two patients.
Conclusion
We introduce a new technique for self-gripping mesh preparation, deployment and placement for inguinal hernia repair using the TEP approach. Our technique seems to have satisfactory results regarding long-term follow-up complications.
Polyvinylidene fluoride dopant as voltage stabilizer for improving high-voltage insulation properties of polypropylene
Authors: Lee Seong Hwan , Kim Do-Kyun , Kwon Tae Hoon , Kwon Ik-Su , Han Dong Hee , Park Hoyyul , Han Se Won , Lee Jin Hong , Lee Dae Ho , Yu Seunggun 
Published: September 2022

Abstract
Various additives ranging from inorganic nanoparticles to organic additives have been suggested to improve the insulation performance of polymeric materials for high-voltage engineering applications. Herein, we present a simple method for doping fluorine into a polypropylene (PP) matrix by melt-blending of isotactic PP (iPP) with a small amount of polyvinylidene fluoride (PVDF) as a thermoplastic voltage stabilizer (TVS). During melt-mixing, the PVDF TVS, which is immiscible with PP, is gradually split into smaller domains within the iPP matrix and was finely distributed, especially at a low PVDF content. The well-distributed PVDF acted as a nucleating agent for the facile crystallization of PP molecules, thus increasing the crystallization temperature (Tc) and decreasing the spherulite size. We found that the direct current (DC) breakdown strength (BDS) values of the PVDF-doped iPP increased by 110% and 149% at 20 and 110°C, respectively, compared to those of the pristine PP. We hypothesize that the presence of fluorine sites as well as the increase in interfaces between spherulites with decreased size, without any significant degradation in the tensile strength and elongation at break below 1.0 phr of PVDF, were the reasons for our findings. Therefore, we anticipate that such PVDF-doped iPP is a potential candidate for high-voltage insulation systems.
Microbiome Analysis of Thai Traditional Fermented Soybeans Reveals Short-Chain Fatty Acid-Associated Bacterial Taxa
Authors: Wongsurawat Thidathip , Sutheeworapong Sawannee , Jenjaroenpun Piroon , Charoensiddhi Suvimol , Khoiri Ahmad Nuruddin , Topanurak Supachai , Sutthikornchai Chantira , Jintaridth Pornrutsami 
Published: September 2022

Abstract
Thua Nao is a Thai traditional fermented soybean food and low-cost protein supplement. Here, we aimed to differentiate the bacteria in Thua Nao from northern Thailand and assess potentially active SCFA-related bacteria. Sixty-six Thua Nao consisting of 30 wet and 35 dried samples were collected from six provinces: Chiang Rai, Chiang Mai, Mae Hong Son, Lampang, Lamphun, and Phayao. Natto, a soybean fermented with starting culture, was also analyzed. Bacterial diversity was significantly higher in the wet samples than in the dried samples. The dominant phyla were Firmicutes (92.7%), Proteobacteria (6.7%), Actinobacteriota (0.42%) and Bacteroidota (0.26%). The genus Bacillus (67%) was the most represented in all samples. Lactobacillus, Enterococcus, and Globicatella were enriched in the wet samples. Assessment of the SCFA-microbiota relationships revealed that high butyrate and propionate concentrations were associated with an increased Clostridiales abundance, and high acetate concentrations were associated with an increased Weissella abundance. Wet products contained more SCFAs, including acetic (P = 2.8e-08), propionic (P = 0.0044), butyric (P = 0.0021), and isovaleric (P = 0.017) acids, than did the dried products. These results provide insight into SCFA-microbiota associations in Thua Nao, which may enable development of starting cultures for SCFA-enriched Thua Nao production.