bluuebunny/crossref_metadata_2025_split huggingface dataset:
La littérature et le cinéma – les expérimentations d’Alain Robbe-Grillet
Authors: Fontanari Rodrigo 
Published: June 2022

Il s’agit d’un entretien avec Claude Murcia, professeur émérite de littérature comparée et d'études cinématographiques à l'université Diderot-Paris 7, sur la relation entre le cinéma et la littérature mais aussi notamment sur l’œuvre cinématographique d’Alain Robbe-Grillet et de ce qu’on nomme par « nouveau cinéma ».
O cinema da literatura: quando a página se torna tela
Authors: Vieira André Soares 
Published: June 2022

Este ensaio busca problematizar uma forma de relação entre o cinema e a literatura, no momento em que essa se vale de procedimentos próprios à linguagem e ao imaginário daquele. Ao considerarmos obras literárias como as que foram produzidas por escritores como Marguerite Duras, Hubert Aquin e Marcio Souza, percebemos zonas de contato que vão desde a referência a um roteiro fictício até o ato de contar filmes. Nesta prespectiva, as obras examinadas evocam outras facetas da « máquina cinematográfica » em suas relações com a literatura, apresentando-se como filmes de textos projetados nas páginas do livro.
Valores civilizatórios em sociedades negro-africanas
Authors: Leite Fábio 
Published: June 2022

Neste texto o autor busca indicar a existência histórica de uma convergência civilizatória crucial para a captação da identidade mais decisiva de sociedades da África negra e para a captação do sentido de processos sociais específicos. Essa convergência aparece manifestada através de alguns valores específicos, apresentados sinteticamente no artigo, integrantes da interpretação do mundo e da organização histórica da realidade, observáveis na atualidade apesar dos processos envolventes desestabilizadores que impactam essas sociedades.
Peroral Endoscopic Myotomy; Novice Surgeon Learning Curve
Authors: Bach Gregory H. , Crowell Winston , Griffith Jennifer , Rachman Ben , Bigness Alec , Reddy Nikhil , Sujka Joseph , Mhaskar Rahul , DuCoin Christopher 
Published: June 2022

Introduction Peroral endoscopic myotomy (POEM) is a novel endoscopic procedure used to treat achalasia and other spastic esophageal disorders that is an alternative to Heller myotomy. We seek to define the learning curve of POEM for a foregut surgeon with no formal endoscopic or POEM training by analyzing different intraoperative factors in a single series. Methods and Procedures The first 38 consecutive patients undergoing POEM by a single foregut surgeon were included in this retrospective study. Inverse curve regression models were used to analyze total operative time (TOT) and total operative time per centimeter of myotomy (TOT-CM), in addition to other intraoperative variables. Clinical outcomes were reported as pre- and post-operative Eckardt Scores. Results All patients had type II achalasia with no post-operative complications observed. Eckardt scores improved postoperatively (median (range): 1 (0-4)) compared with the preoperative scores (10 (8-12)) (P < .001). The total operative time (median 76 minutes, range 51-129) decreased significantly over the course of the series (R2 = .38, P < .001), with a learning plateau at 70 minutes and a learning rate of 12 cases. Total operative time per centimeter of myotomy (median 7.08 min/cm, range 4.25 to 15.38) decreased over time (R2 = .45, P < .001), with a learning plateau at 7 minutes/cm and a learning rate of 12 cases. Conclusion The number of cases for a foregut surgeon to become proficient in a POEM procedure was found to be 12-14 cases. The learning curve for a POEM in a formally trained foregut surgeon may be comparable to an endoscopically trained interventionist.
Echocardiographic Association of Epicardial Adipose Tissue with Ascending Aorta Elasticity in Patients with Type 2 Diabetes Mellitus
Authors: Song Xiang-Ting , Rui Yi-Fei , Fan Li , Yan Zi-Ning 
Published: June 2022

Epicardial adipose tissue (EAT) is an emerging cardiovascular risk factor located between the myocardium and visceral pericardium. In order to investigate the association between EAT and ascending aorta elasticity in patients with type 2 diabetes mellitus (T2DM), we prospectively enrolled a total of 135 T2DM patients and 63 age- and gender-matched non-T2DM controls in this study. They all underwent transthoracic echocardiography to measure EAT thickness and ascending aorta inner diameters which were used to calculate ascending aorta elastic parameters: compliance (C), distensibility (D), strain (S), stiffness index (SI), and Peterson’s elastic modulus (EM). We found that the values of C, D, and S were significantly lower, while SI, EM, and EAT thickness were significantly higher in T2DM patients compared with non-T2DM controls. Compared with T2DM patients with EAT < 5 mm group, C, D, and S were significantly reduced, SI and EM were significantly increased in T2DM patients with EAT ≥ 5 mm group (all P < .05). Bivariate correlation and multivariate linear regression analysis revealed that EAT was independently associated with ascending aorta elasticity. Our findings suggest that thickened EAT in patients with T2DM is associated with ascending aorta elasticity, independent of blood glucose.
Stock Returns, Trading Volumes and Market Volatility: A Study on the Indian Stock Market
Authors: Naik Pramod Kumar , Sethy Tapas Kumar 
Published: June 2022

This paper aims at investigating the effect of stock returns on trading volume and the trading volume on volatility. To accomplish the study objective, daily data from 1 April 2014 to 30 June 2020 are used. The GLS model is employed to investigate the contemporaneous relationship between the stock returns and trading volume. The EGARCH (1, 1) model is used to explore the volume–volatility relationships, and the causal relationship of stock returns–trading volumes–volatility is attained through the Granger causality test. The study finds that the effect of stock returns on trading volume is asymmetric. It indicates that the negative price changes have a less considerable impact on trading volume than the non-negative price changes. The study also supports the mixture of the distribution hypothesis that postulated the volume–volatility relationship to be positive. The volatility persistence level remains high, even after the conditional volatility model incorporates trading volumes as an exogenous variable. Further, the analysis also reveals that stock return causes trading volume and not vice versa; however, trading volumes cause return volatility. JEL Codes: G10, G12, C22
Can a new ward environment and intensive allied health staffing model enhance therapeutic opportunities in trauma care? A behavioural mapping study of patients’ activities and interactions
Authors: Ekegren Christina L , Mather Anne M , Reeder Sandra , Kimmel Lara , Ashe Maureen C , Gabbe Belinda J 
Published: June 2022

Objective The aim of this study was to assess changes in patient activities and interactions observed in response to a new trauma ward at a level 1 trauma centre, and subsequently, a new allied health staffing model. Design Explorative case study using behavioural mapping. Setting Level 1 trauma centre in Melbourne, Australia. Participants Hospitalised trauma patients. Main measures Behavioural mapping of patients’ activities and interactions was conducted by two observers over three 4-day observation phases: (i) at baseline, (ii) on the new ward and (iii) with the new staffing model. Changes in activities and interactions were assessed via negative binomial regression models and reported as incident rate ratios. Results In total, 1264 patient observations were recorded over an 18-month period. After moving to the new ward, patients were observed performing activities of daily living at a 2.1-fold higher rate than at baseline (95% confidence interval: 1.18, 3.81) but walking/standing/climbing stairs 54% less (95% confidence interval: 0.22, 0.94). Subsequent to the new staffing model, patients were observed in the gym at a 4.1-fold higher rate (95% confidence interval: 1.60, 10.32) and interacting with allied health professionals at a 9.1-fold higher rate (95% confidence interval: 4.88, 16.98), than at baseline. After COVID-19 restrictions were introduced, patients were observed lying down 22% more (95% confidence interval: 1.04, 1.43), with 73% fewer visitor interactions (95% confidence interval: 0.17, 0.43). Conclusions Greater engagement in physical and social activities was observed following the implementation of the new allied health staffing model at a level 1 trauma centre. Whether these changes translate to improved trauma outcomes is important to investigate.
Pharmacological characterization of a novel putative nootropic beta-alanine derivative, MB-005, in adult zebrafish
Authors: Kolesnikova Tatiana O , Galstyan David S , Demin Konstantin A , Barabanov Mikhail A , Pestov Alexander V , S de Abreu Murilo , Strekalova Tatyana , Kalueff Allan V 
Published: June 2022

Background: Cognitive deficits represent an urgent biomedical problem, and are commonly reduced by nootropic drugs. Animal models, including both rodents and zebrafish, offer a valuable tool for studying cognitive phenotypes and screening novel nootropics. Beta-alanine and its derivatives have recently been proposed to exert nootropic activity. Aims: This study aimed to characterize putative nootropic profile of a novel β-alanine analogue, 1,3-diaminopropane (MB-005), in adult zebrafish. Methods: Nootropic profile of MB-005 was assessed in adult zebrafish in the novel tank and conditioned place aversion (CPA) tests acutely, and in cued-learning plus-maze (PMT) tests chronically. Results/Outcomes: MB-005 did not alter zebrafish anxiety-like behavior or monoamine neurochemistry acutely, improved short-term memory in the CPA test, but impaired cognitive performance in both CPA and PMT tests chronically. Conclusions/Interpretation: This study reveals high sensitivity of zebrafish cognitive phenotypes to MB-005, suggesting it as a potential novel cognitive enhancer acutely, but raises concerns over its cognitive (and, possibly, other) side-effects chronically.
Potential Interaction Between Sepsis and Acute Respiratory Distress Syndrome and Effect on the 6-Month Clinical Outcomes: A Preliminary Secondary Analysis of a Prospective Observational Study
Authors: Okazaki Tomoya , Kawakami Daisuke , Fujitani Shigeki , Shinohara Natsuyo , Kawakita Kenya , Kuroda Yasuhiro ,   on behalf of the J-PICS study group
Published: June 2022

Background This study aimed to investigate the effect of the potential interaction between sepsis and acute respiratory distress syndrome (ARDS) on the 6-month clinical outcomes. Methods This secondary analysis of a prospective multicenter observational study included patients who were expected to receive mechanical ventilation for more than 48 h. Patients were stratified based on the incidence of sepsis and further subdivided according to the presence of ARDS. The primary endpoints for patients whose follow-up information was available included mortality (n = 162) and the occurrence of PICS (n = 96) at six months. The diagnosis of PICS was based on any of the following criteria: (1) decrease ≥ 10 points in the physical component score of the 36-item Short Form (SF36) questionnaire; (2) decrease ≥ 10 points in the mental component score of the SF-36; or (3) decline in the Short Memory Questionnaire (SMQ) score and SMQ score < 40 at six months after ICU admission. We conducted multivariate logistic regression analyses to assess the effect of the potential interaction between ARDS and sepsis on the 6-month clinical outcomes. Results The mortality in the ARDS sub-group was higher than that in the non-ARDS subgroup [47% (7/15) versus 21% (18/85)] in the non-sepsis group. However, the mortality in the ARDS and non-ARDS subgroups was similar in the sepsis group. Multivariate logistic regression analyses revealed that ARDS was significantly associated with mortality in the non-sepsis group (adjusted OR: 5.25; 95% CI: 1.45-19.09; p = .012), but not in the sepsis group (P for interaction = .087). Multivariate logistic regression analyses showed ARDS was not associated with PICS occurrence in the non-sepsis and sepsis groups (P-value for the interaction = .039). Conclusions This hypothesis-generating study suggested that the effect of ARDS on the 6-month outcomes depended on the presence or absence of sepsis. Trial registration Not applicable
Motivating Protective Behavior against COVID-19: Fear Versus Hope
Authors: Sand Gregor , Bristle Johanna 
Published: June 2022

Objectives Based on protection motivation theory, we investigate how indicators of threat perception (perceived severity, perceived vulnerability, and fear arousal) and coping appraisal (hope) are associated with older people’s motivation to engage in protective behavior after the outbreak of COVID-19. Methods We use multivariate regression analyses with a sample of 40,282 individuals from 26 countries participating in the SHARE Corona Survey. Results We find that 15% of all respondents stayed home completely—mainly the oldest and vulnerable people with prior health risk conditions. On average, older Europeans responded strongly to the recommended protective behavior measures (6 out of 7 measures adopted). Among the threat perception indicators, fear arousal is the main motivator for protective behavior, whereas the coping appraisal indicator hope shows an equally strong association. Discussion Given the negative health effects of fear, our findings may help evaluate and revise governmental policy responses and communication strategies.
An evaluation method for transient response performance of a turbocharger in gasoline engine: Simulation and experiment
Authors: Wang Zhihui , Ma Chaochen , Wang Hengjun 
Published: June 2022

The vital issue of response lag and soot emission during transient operation of turbocharged engine, has been studied so far mainly on experiment in engine system rather than turbocharger basis. The study of turbocharger transient performance, however, is extremely important to manufacturers due to the stringent regulations of exhaust emission and economy for the turbocharger engine. Therefore, a general method independent of the engine for evaluating the transient response performance of a gasoline turbocharger is proposed in this paper. First, an explicit relationship between key thermodynamic parameters of turbine and compressor and the evaluation index of [Formula: see text] that can characterize turbocharger transient response are established. Secondly, the proposed evaluation method is tested and verified using the coupling between GT-Power and MATLAB Simulink software based on the gasoline turbocharger. The simulation results show that the appropriate conditions should be selected for the transient response test, including the starting and ending speed, the starting mass flow rate, etc. For this proposed turbocharger, the value of [Formula: see text] has a good consistency when the ending speed is 200,000 r/min and the initial mass flow rate is in the range of 0.0715∼0.0756 kg/s. Moreover, the influence of rotor moment of inertia, turbine efficiency and compressor efficiency on [Formula: see text] is analyzed in this selected condition. Finally, the evaluating method of the transient response performance of the turbocharger is conducted on a test bench. The test results are in good agreement with the simulation results, indicating that the proposed evaluation method for transient response of turbocharger has a good predictability and can be used for quantitative evaluation of transient response-ability for different turbochargers independent of engine.
Longitudinal Morphological Changes in the Mucosal Free Margin After Unilateral Cleft Lip Repair
Authors: Nakajima Yuta , Yuzuriha Shunsuke , Nagai Fumio 
Published: June 2022

Weakness of the mucosal free margin is common in secondary cleft lip deformities. However, the incidence is rarely reported after a long-term follow-up. We evaluated the evolution of patient mucosal free margin after primary repair and until the end of growth. Blinded retrospective study (photography and chart reviews). Tertiary care hospital; private practice. Forty-eight patients with unilateral cleft lip with or without cleft palate who underwent primary nasolabial repair between 1996 and 2004 were followed up until their end of growth marked at 18 and 16 years of age for male and female patients, respectively. Primary nasolabial repair using a straight-line closure without a triangular flap on the vermilion was performed; if needed, a revision surgery was performed at 5 years of age (85%). The contour of the mucosal free margin was classified into nodular, smooth, and recessed types at 1, 5, and 10 years and at the end of growth. At 1 year of age, the nodular type was more common (58%). However, the recessed type was more common (75%) at the end of growth. The mucosal free margin continued to change after 10 years of age. At the end of growth, half of the patients with incomplete cleft experienced center weakness, and the others had cleft-side weaknesses. Patients with incomplete clefts showed favorable results at early ages. However, two-thirds of the patients with complete and incomplete clefts showed focal weakness at the end of growth.
Vasopressin-Induced Hyponatremia in Infants Following Cardiovascular Surgery
Authors: Bradford Caitlyn V. , Miller Jamie L. , Ranallo Courtney D. , Neely Stephen B. , Johnson Peter N. 
Published: June 2022

Background Vasopressin is increasingly used in infants following cardiac surgery. Hyponatremia is a noted adverse event, but incidence and risk factors remain undefined. Objective The primary objective was to identify the incidence of vasopressin-induced hyponatremia. Secondary objectives included comparing baseline and change in serum sodium concentrations between infants receiving vasopressin with and without hyponatremia, and comparing vasopressin dose, duration, and clinical characteristics in those with and without hyponatremia. Methods This Institutional Review Board–approved, retrospective case-control study included infants <6 months following cardiac surgery receiving vasopressin for ≥6 hours at a tertiary care, academic hospital. Patients who developed hyponatremia, cases, were matched to controls in a 1:2 fashion. Demographics and clinical characteristics were collected. Descriptive and inferential statistics were employed. A conditional logistic regression was used to assess odds of hyponatremia. Results Of the included 142 infants, 20 (14.1%) developed hyponatremia and were matched with 40 controls. There was significant difference in median nadir between controls and cases, 142.0 versus 128.5 mEq/L (<0.001). A significantly higher number of cases received corticosteroids, loop diuretics, and chlorothiazide versus controls. The regression analysis demonstrated that each additional hour of vasopressin increased the odds of developing hyponatremia by 5% (adjusted odds ratio 1.05 [confidence interval 1-1.1]). Conclusions and relevance Vasopressin-induced hyponatremia incidence was <15%. Vasopressin duration was independently associated with hyponatremia development.
Elevated Levels of Pleiotropic Interleukin-6 (IL-6) and Interleukin-10 (IL-10) are Critically Involved With the Severity and Mortality of COVID-19: An Updated Longitudinal Meta-Analysis and Systematic Review on 147 Studies
Authors: Jafrin Sarah , Aziz Md. Abdul , Islam Mohammad Safiqul 
Published: June 2022

Objectives: Disruption in the natural immune reaction due to SARS-CoV-2 infection can initiate a potent cytokine storm among COVID-19 patients. An elevated level of IL-6 and IL-10 during a hyperinflammatory state plays a vital role in increasing the risk of severity and mortality. In this study, we aimed to evaluate the potential of circulating IL-6 and IL-10 levels as biomarkers for detecting the severity and mortality of COVID-19. Methods: This study was conducted according to the Cochrane Handbook and PRISMA guidelines. Authorized databases were searched to extract suitable studies using specific search terms. RevMan 5.4 was applied for performing the meta-analysis. Mean differences in IL-6 and IL-10 levels were calculated among COVID-19 patients via a random-effects model. NOS scoring, publication bias and sensitivity analyses were checked to ensure study quality. Results: A total of 147 studies were selected, with 31 909 COVID-19 patients under investigation. In the severity analysis, the mean concentration of IL-6 was significantly higher in the severe COVID-19 cases than in the non-severe cases (MD: 19.98; P < .001; 95% CI: 17.56, 22.40). Similar result was observed for IL-10 mean concentration in severe COVID-19 cases (MD: 1.35; P < .001; 95% CI: 0.90, 1.80). In terms of mortality analysis, circulating IL-6 showed sharp elevation in the deceased patients (MD: 42.11; P < .001; 95% CI: 36.86, 47.36). IL-10 mean concentration was higher in the dead patients than in the survived patients (MD: 4.79; P < .001; 95% CI: 2.83, 6.75). Publication bias was not found except for comparing IL-6 levels with disease severity. Sensitivity analysis also reported no significant deviation from the pooled outcomes. Conclusions: Elevated levels of circulating IL-6 and IL-10 signifies worsening of COVID-19. To monitor the progression of SARS-CoV-2 infection, IL-6 and IL-10 should be considered as potential biomarkers for severity and mortality detection in COVID-19. Systematic review registration: INPLASY registration number: INPLASY202240046.
Molecular mechanisms underlying the resistance of BRAF V600E-mutant metastatic colorectal cancer to EGFR/BRAF inhibitors
Authors: Xu Ting , Wang Xicheng , Wang Zhenghang , Deng Ting , Qi Changsong , Liu Dan , Li Yanyan , Ji Congcong , Li Jian , Shen Lin 
Published: June 2022

Background: Combinatorial inhibition of epidermal growth factor receptor (EGFR) and BRAF shows remarkable clinical benefits in patients with BRAF V600E-mutant metastatic colorectal cancer (mCRC). However, the tumor may inevitably develop resistance to the targeted therapy, thereby limiting the response rate and durability. This study aimed to determine the genetic alterations associated with intrinsic and acquired resistance to EGFR/BRAF inhibitors in BRAF V600E-mutant mCRC. Methods: Targeted sequencing of 520 cancer-related genes was performed in tumor tissues and in plasma samples collected from patients with BRAF V600E-mutant mCRC, who were treated with EGFR/BRAF ± MEK inhibitors, before and after the targeted treatment. Clinical benefit was defined as an objective response or a stable disease lasting longer than the median progression-free survival (PFS). Results: In all, 25 patients with BRAF V600E-mutant mCRC were included in this study. Those with RNF43 mutations ( n = 8) were more likely to achieve clinical benefit from EGFR/BRAF inhibitors than those with wild-type RNF43 (87.5% versus 37.5%, p = 0.034). Genetic alterations in receptor tyrosine kinase genes ( n = 6) were associated with worse PFS ( p = 0.005). Among the 23 patients whose disease progressed after the EGFR/BRAF-targeted therapy, at least one acquired resistance-related mutation was detected in 12 patients. Acquired mutations were most frequently observed in the mitogen-activated protein kinase pathway-related genes ( n = 9), including KRAS (G12D and Q61H/R), NRAS (Q61L/R/K and amplification), BRAF (amplification), and MEK1 (K57T). MET amplification and PIK3R1 Q579fs mutation emerged in three patients and one patient, respectively, after disease progression. Conclusion: Multiple genetic alterations are associated with clinical benefits and resistance to EGFR/BRAF inhibitors in BRAF V600E-mutant mCRC. Our findings provide novel insights into strategies for overcoming resistance to EGFR/BRAF inhibitors in patients with BRAF V600E-mutant mCRC.