bluuebunny/crossref_metadata_2025_split huggingface dataset:
Quality evaluation of oil by cold‐pressed peanut from different growing regions in China
Authors: Huang Ying , Liu Changsheng , Huang Fenghong , Zhou Qi , Zheng Chang , Liu Rui , Huang Jiazhang 
Published: March 2022

AbstractIn this study, twenty‐six peanut varieties and their cold‐pressed oils from eleven provinces in China were investigated for their oil content, acid value, peroxide value, fatty acid profiles, bioactive constituents, and induction period (IP) of lipid oxidation. Meanwhile, the effect of the geographical origin of peanut on the quality of cold‐pressed peanut oils (CPOs) was studied. The average acid value of CPOs in southern China was higher than that in northern China (0.49 mg KOH/g versus 0.22 mg KOH/g, p > .05). In addition, the average of oleic acid content, ratio of oleic acid to linoleic acid (O/L), and IP were also higher in southern China than that in northern China (p < .05). However, the average content of campesterol, β‐sitosterol, total phytosterol, linoleic acid, and ratio of unsaturated fatty acid to saturated fatty acid (UFA/SFA) exhibited reverse results (p < .05). At last, the comprehensive evaluation of CPOs based on principal component analysis (PCA) was performed. In all samples, Silihong from Liaoning province, northern China was No.1, and Zhonghua 21 from Xiaogan City, Hubei Province was No.4 which was the first one from southern China. Moreover, heat map clustering analysis further revealed the differences and similarities among different samples, and those results were in accordance with the comprehensive evaluation results.
Qualitative and quantitative analyses of chemical components of Citri Sarcodactylis Fructus from different origins based on UPLC–Q–Exactive Orbitrap–MS and GC–MS
Authors: Ning Jinrong , Wang Kanghui , Yang Wanling , Liu Mengshi , Tian Jingyuan , Wei Minyan , Zheng Guodong 
Published: March 2022

AbstractUltra‐high‐performance liquid chromatography–Q–Exactive Orbitrap–mass spectrometry (MS) and gas chromatography (GC)–MS were performed for the qualitative and quantitative analyses of Citri Sarcodactylis Fructus (CSF) from different origins. The contents of eight major CSF components, namely 5,7‐dimethoxycoumarin, scopoletin, hesperidin, tangeretin, nobiletin, limonin, nomilin, and stachydrine, were quantitatively analyzed. Clustering analysis and principal component analysis (PCA) were, respectively, performed to classify and compare the 10 CSF batches. One hundred and two volatile components were identified accordingly by comparing retention times, reference standards, parent peaks, fragment peaks, and findings from relevant literature. Moreover, high content of 5,7‐dimethoxycoumarin and stachydrine was detected in all the CSFs, especially in CSF‐Zhe. Therefore, the high content component coumarin “5,7‐dimethoxycoumarin” was suggested to be quality analysis component rather than hesperidin. Additionally, characteristic compounds were found to distinguish different CSFs. This work was a comprehensive study about the components of various CSF. It distinguished the basic differences in the compositions of CSF from different origins. Eventually, it provided experimental and systematic bases for the quality control analysis of CSF, which has potential application in the further research.
Structural connectivity associated with familial risk for mental illness: A meta‐analysis of diffusion tensor imaging studies in relatives of patients with severe mental disorders
Authors: Xu Mengyuan , Zhang Wenjing , Hochwalt Paul , Yang Chengmin , Liu Naici , Qu Jiao , Sun Hui , DelBello Melissa P. , Lui Su , Nery Fabiano G. 
Published: March 2022

AbstractSchizophrenia (SCZ), bipolar disorder (BD), and major depressive disorder (MDD) are heritable conditions with overlapping genetic liability. Transdiagnostic and disorder‐specific brain changes associated with familial risk for developing these disorders remain poorly understood. We carried out a meta‐analysis of diffusion tensor imaging (DTI) studies to investigate white matter microstructure abnormalities in relatives that might correspond to shared and discrete biomarkers of familial risk for psychotic or mood disorders. A systematic search of PubMed and Embase was performed to identify DTI studies in relatives of SCZ, BD, and MDD patients. Seed‐based d Mapping software was used to investigate global differences in fractional anisotropy (FA) between overall and disorder‐specific relatives and healthy controls (HC). Our search identified 25 studies that met full inclusion criteria. A total of 1,144 relatives and 1,238 HC were included in the meta‐analysis. The overall relatives exhibited decreased FA in the genu and splenium of corpus callosum (CC) compared with HC. This finding was found highly replicable in jack‐knife analysis and subgroup analyses. In disorder‐specific analysis, compared to HC, relatives of SCZ patients exhibited the same changes while those of BD showed reduced FA in the left inferior longitudinal fasciculus (ILF). The present study showed decreased FA in the genu and splenium of CC in relatives of SCZ, BD, and MDD patients, which might represent a shared familial vulnerability marker of severe mental illness. The white matter abnormalities in the left ILF might represent a specific familial risk for bipolar disorder.
Zapline‐plus: A Zapline extension for automatic and adaptive removal of frequency‐specific noise artifacts in M/EEG
Authors: Klug Marius , Kloosterman Niels A. 
Published: March 2022

AbstractRemoving power line noise and other frequency‐specific artifacts from electrophysiological data without affecting neural signals remains a challenging task. Recently, an approach was introduced that combines spectral and spatial filtering to effectively remove line noise: Zapline. This algorithm, however, requires manual selection of the noise frequency and the number of spatial components to remove during spatial filtering. Moreover, it assumes that noise frequency and spatial topography are stable over time, which is often not warranted. To overcome these issues, we introduce Zapline‐plus, which allows adaptive and automatic removal of frequency‐specific noise artifacts from M/electroencephalography (EEG) and LFP data. To achieve this, our extension first segments the data into periods (chunks) in which the noise is spatially stable. Then, for each chunk, it searches for peaks in the power spectrum, and finally applies Zapline. The exact noise frequency around the found target frequency is also determined separately for every chunk to allow fluctuations of the peak noise frequency over time. The number of to‐be‐removed components by Zapline is automatically determined using an outlier detection algorithm. Finally, the frequency spectrum after cleaning is analyzed for suboptimal cleaning, and parameters are adapted accordingly if necessary before re‐running the process. The software creates a detailed plot for monitoring the cleaning. We highlight the efficacy of the different features of our algorithm by applying it to four openly available data sets, two EEG sets containing both stationary and mobile task conditions, and two magnetoencephalography sets containing strong line noise.
Immunocompromised rabbit model of chronic HEV reveals liver fibrosis and distinct efficacy of different vaccination strategies
Authors: He Qiyu , Zhang Fan , Shu Jingyi , Li Shuangshuang , Liang Zhaochao , Du Minghao , Liu Xing , Liu Tianxu , Li Manyu , Yin Xin , Pan Qiuwei , Lu Fengmin , Wang Ling , Wang Lin 
Published: March 2022

Abstract

Background and Aims
HEV infection can lead to chronicity and rapid progression to liver fibrosis and cirrhosis in immunocompromised organ transplant recipients. Robust animal models are urgently needed to study the pathogenesis and test the efficacy of vaccines and antiviral drugs in immunosuppressed settings.

Approach and Results
Cyclosporin A was used to induce immunosuppression. Rabbits were challenged with genotype 3 or 4 HEV (i.e., the rabbit‐derived HEV3 and human‐derived HEV3 or HEV4). We assessed HEV markers within 13 weeks post inoculation (wpi) and pathological changes by hematoxylin and eosin and Masson staining at 4, 8, or 13 wpi. Chronic HEV infection was successfully established in immunocompromised rabbits. HEV RNA and/or antigens were detected in the liver, kidney, intestine, urine, and cerebrospinal fluid samples. Chronically infected animals exhibited typical characteristics of liver fibrosis development. Intrahepatic transcriptomic analysis indicated activation of both innate and adaptive immunity. Establishment of HEV chronicity likely contributed to the inhibited T‐cell immune response. Ribavirin is effective in clearing HEV infection in immunocompromised rabbits. Most interestingly, vaccination completed before immunosuppression conferred full protection against both HEV3 and HEV4 infections, but vaccination during immunosuppression was only partially protective, and the efficacy did not improve with increased or additional vaccine doses.

Conclusions
The immunocompromised rabbit model of both chronic HEV3 and HEV4 infection that was established captured the key features of chronic HEV infection in transplant patients, including liver fibrogenesis, and revealed the distinct effectiveness of vaccination administered before or under immunosuppression. This rabbit model is valuable for understanding the pathogenesis of chronic hepatitis E, as well as for evaluating antiviral agents and vaccines.
Portal fibroblasts with mesenchymal stem cell features form a reservoir of proliferative myofibroblasts in liver fibrosis
Authors: Lei Lin , Bruneau Alix , El Mourabit Haquima , Guégan Justine , Folseraas Trine , Lemoinne Sara , Karlsen Tom Hemming , Hoareau Bénédicte , Morichon Romain , Gonzalez‐Sanchez Ester , Goumard Claire , Ratziu Vlad , Charbord Pierre , Gautheron Jérémie , Tacke Frank , Jaffredo Thierry , Cadoret Axelle , Housset Chantal 
Published: March 2022

Abstract

Background and Aims
In liver fibrosis, myofibroblasts derive from HSCs and as yet undefined mesenchymal cells. We aimed to identify portal mesenchymal progenitors of myofibroblasts.

Approach and Results
Portal mesenchymal cells were isolated from mouse bilio‐vascular tree and analyzed by single‐cell RNA‐sequencing. Thereby, we uncovered the landscape of portal mesenchymal cells in homeostatic mouse liver. Trajectory analysis enabled inferring a small cell population further defined by surface markers used to isolate it. This population consisted of portal fibroblasts with mesenchymal stem cell features (PMSCs), i.e., high clonogenicity and trilineage differentiation potential, that generated proliferative myofibroblasts, contrasting with nonproliferative HSC‐derived myofibroblasts (‐MF). Using bulk RNA‐sequencing, we built oligogene signatures of the two cell populations that remained discriminant across myofibroblastic differentiation. SLIT2, a prototypical gene of PMSC/PMSC‐MF signature, mediated profibrotic and angiogenic effects of these cells, which conditioned medium promoted HSC survival and endothelial cell tubulogenesis. Using PMSC/PMSC‐MF 7‐gene signature and slit guidance ligand 2 fluorescent in situ hybridization, we showed that PMSCs display a perivascular portal distribution in homeostatic liver and largely expand with fibrosis progression, contributing to the myofibroblast populations that form fibrotic septa, preferentially along neovessels, in murine and human liver disorders, irrespective of etiology. We also unraveled a 6‐gene expression signature of HSCs/HSC‐MFs that did not vary in these disorders, consistent with their low proliferation rate.

Conclusions
PMSCs form a small reservoir of expansive myofibroblasts, which, in interaction with neovessels and HSC‐MFs that mainly arise through differentiation from a preexisting pool, underlie the formation of fibrotic septa in all types of liver diseases.
Accurate long‐term prediction of death for patients with cirrhosis
Authors: Goldberg David , Mantero Alejandro , Kaplan David , Delgado Cindy , John Binu , Nuchovich Nadine , Emanuel Ezekiel , Reese Peter P. 
Published: March 2022

Abstract

Background and Aims
Cirrhosis is a major cause of death and is associated with extensive health care use. Patients with cirrhosis have complex treatment choices due to risks of morbidity and mortality. To optimally counsel and treat patients with cirrhosis requires tools to predict their longer‐term liver‐related survival. We sought to develop and validate a risk score to predict longer‐term survival of patients with cirrhosis.

Approach and Results
We conducted a retrospective cohort study of adults with cirrhosis with no major life‐limiting comorbidities. Adults with cirrhosis within the Veterans Health Administration were used for model training and internal validation, and external validation used the OneFlorida Clinical Research Consortium. We used four model‐building approaches including variables predictive of cirrhosis‐related mortality, focused on discrimination at key time points (1, 3, 5, and 10 years). Among 30,263 patients with cirrhosis ≤75 years old without major life‐limiting comorbidities and complete laboratory data during the baseline period, the boosted survival tree models had the highest discrimination, with 1‐year, 3‐year, 5‐year, and 10‐year survival rates of 0.77, 0.81, 0.84, and 0.88, respectively. The 1‐year, 3‐year, and 5‐year discrimination was nearly identical in external validation. Secondary analyses with imputation of missing data and subgroups by etiology of liver disease had similar results to the primary model.

Conclusions
We developed and validated (internally and externally) a risk score to predict longer‐term survival of patients with cirrhosis. This score would transform management of patients with cirrhosis in terms of referral to specialty care and treatment decision‐making for non‐liver‐related care.
A generalized analytical solution of groundwater head response to dual tide in a multi‐layered island leaky aquifer system
Authors: Zhao Zhi‐Xue , Hao Yonghong , Wang Tongke , Yeh Tian‐Chyi Jim , Zhang Ming 
Published: March 2022

AbstractThe hydraulic properties of coastal aquifer systems are relevant to various hydrogeological, hydro‐ecological and engineering problems. This study presents an analytical solution for predicting groundwater head fluctuations induced by dual‐tide in multi‐layered island aquifer systems, consisting of an unconfined aquifer on the top and any number of leaky aquifers below. The solution was derived via the methods of matrix differential calculus and separation of variables. It is more general than any existing analytical solutions for the tidal pressure propagation since the new solution can consider multi‐layered aquifer systems along with the effects of leakage and aquifer length. Using this solution, we illustrated potential errors that may occur due to neglecting one or more vital factors affecting groundwater fluctuations. Besides, we articulated the groundwater response to the dual‐tide in complex coastal aquifers. Considering that some thin semipermeable layers may be ignored in practical field investigation, we also demonstrated the effects due to simplification of aquifer layers. The results showed that with the increase in the number of overlapped leaky layers, the tidal propagation in the bottom part of multi‐layered aquifer system approaches that in a single confined aquifer with the same transmissivity and storage.
Trend of nasopharyngeal carcinoma mortality and years of life lost in China and its provinces from 2005 to 2020
Authors: Long Zheng , Wang Wei , Liu Wei , Wang Feixue , Meng Shidi , Liu Jiangmei , Liu Yunning , Qi Jinlei , Wang Lijun , Zhou Maigeng , Yin Peng 
Published: March 2022

AbstractTo examine the trends of nasopharyngeal carcinoma (NPC) mortality and years of life lost (YLL) in China and its provinces from 2005 to 2020, our study used data from China National Mortality Surveillance System (NMSS) to estimate the number and rate of mortality and YLL of NPC by age and sex. We calculated average annual percent change (AAPC) to describe the trend of NPC mortality and YLL over time. We also analyzed the proportion of NPC deaths in all cancer deaths and explored the drivers of change in NPC deaths by decomposition analysis. The age‐standardized mortality rate (ASMR) of NPC in China had a significant downward trend from 2.0/100 000 in 2005 to 1.4/100 000 in 2020 (AAPC = −2.4, P < .05). Age‐standardized YLL rate also showed the similar trends (AAPC = −2.8, P < .05). Southern provinces including Guangdong (163.9/100 000), Guangxi (130.5/100 000), and Hainan (105.6/100 000) had the highest YLL rate in 2020. The mortality and YLL rate increased with age and males were higher than females. From 2005 to 2020, the proportion of NPC deaths in all cancer deaths remained stable at around 1.0% in China. The total number of deaths of NPC increased by 7.3%, of which age‐specific mortality, population growth, and population aging accounted for −46.2%, 8.5% and 45.0%, respectively. NPC remains a significant public health issue in China southern provinces and tailored prevention and control strategies should be strengthened to reduce the burden of premature mortality of NPC in high risk areas.
Global patterns in testicular cancer incidence and mortality in 2020
Authors: Znaor Ariana , Skakkebaek Niels Erik , Rajpert‐De Meyts Ewa , Kuliš Tomislav , Laversanne Mathieu , Gurney Jason , Sarfati Diana , McGlynn Katherine A. , Bray Freddie 
Published: March 2022

AbstractWith 74 500 new cases worldwide in 2020, testicular cancer ranks as the 20th leading cancer type, but is the most common cancer in young men of European ancestry. While testicular cancer incidence has been rising in many populations, mortality trends, at least those in high‐income settings, have been in decline since the 1970s following the introduction of platinum‐based chemotherapy. To examine current incidence and mortality patterns, we extracted the new cases of, and deaths from cancers of the testis from the GLOBOCAN 2020 database. In 2020, testicular cancer was the most common cancer in men aged 15 to 44 in 62 countries worldwide. Incidence rates were highest in West‐, North‐ and South‐Europe and Oceania (age‐standardised rate, ASR ≥7/100 000), followed by North America (5.6/100 000 and lowest (<2/100 000) in Asia and Africa. The mortality rates were highest in Central and South America (0.84 and 0.54 per 100 000, respectively), followed by Eastern and Southern Europe, and Western and Southern Africa. The lowest mortality rates were in Northern Europe, Northern Africa and Eastern Asia (0.16, 0.14, 0.9 per 100 000, respectively). At the country level, incidence rates varied over 100‐fold, from 10/100 000 in Norway, Slovenia, Denmark and Germany to ≤0.10/100 000 in Gambia, Guinea, Liberia, Lesotho. Mortality rates were highest in Fiji, Argentina and Mexico. Our results indicate a higher mortality burden in countries undergoing economic transitions and reinforce the need for more equitable access to testicular cancer diagnosis and treatment globally.
Is there an association between isolated sonographic abdominal circumference below the 10th percentile and placental vascular lesions?
Authors: Torem Maya , Marom Or , Gonen Noa , Gindes Liat , Schreiber Letizia , Kovo Michal 
Published: March 2022

AbstractObjectiveTo study the association between prenatal diagnosis of isolated abdominal circumference (AC) below the 10th percentile (AC <10th) in appropriate for gestational age (AGA) neonates and placental vascular lesions.MethodsA prospective study was conducted of healthy women who underwent sonographic fetal biometric measurements, up to 7 days before delivery, and delivered AGA neonates. The study cohort was divided into those with and without prenatal isolated AC <10th. Placental histopathology lesions were classified into maternal and fetal vascular malperfusion (MVM, FVM) lesions.ResultsCompared to the AC over 10th percentile group (n = 85), the AC <10th group (n = 85) was characterized by lower maternal body mass index, higher rate of smokers, and increased rate of induced labor (P = 0.029, P = 0.029, P = 0.001, respectively). There were no between‐group differences regarding maternal age, gestational age, and neonatal outcome. Mean placental weight was lower in the isolated AC <10th (P < 0.001). The rate of MVM or FVM lesions did not differ between the groups. By multivariate logistic regression analysis, isolated AC <10th was not found to be associated with increased risk for placental vascular lesions.ConclusionIsolated AC <10th is associated with increased rate of induction of labor; however, it is not associated with increased placental vascular lesions.
Categorization of breast masses based on deep belief network parameters optimized using chaotic krill herd optimization algorithm for frequent diagnosis of breast abnormalities
Authors: Chandraraju Thirumarai Selvi , Jeyaprakash Amudha 
Published: March 2022

AbstractSeveral deep learning techniques are utilized for classification of the masses in mammogram images. But the existing method doesnot provide sufficient accuracy . for breast masses classification in mammogram images. In this manuscript, an efficient breast cancer image classification framework utilizing the deep belief network (DBN) through chaotic krill herd optimization (CKHO) algorithm for classification of masses in mammogram images is proposed. Initially the input mammogram images are pre‐processed by altered phase preserving dynamic range compression (APPDRC) method for removing the unwanted noise and artifacts. Then these pre‐processed images are assumed with DBN for classifying that mass in the mammogram images into normal, benign, and malignant lesions. Generally, DBN does not reveal any acceptance of optimization techniques for computing optimal parameters that guarantee an accurate classification. Therefore in this work, proposed CKHO algorithm is employed for optimizing weight parameters of the self‐attention convolutional neural network (SACNN). The simulation process is performed under MATLAB platform. Finally, the proposed DBN with chaotic krill herd optimization algorithm (DBN‐CKHO) attains high accuracy 44.5%, 33.42%, 55.23%, 62.35%, and 43.42% when compared with the existing method such as extreme learning machine classifier with moth flame optimization (ELMC‐MFO), Kernel extreme learning machine classifier with Chaotic salp swarm algorithm (KELMC‐CSSA), Extreme learning machine classifier with fruit fly optimization algorithm (ELMC‐FOA), Kernel extreme learning machine classifier with grasshopper optimization algorithm (KELMC‐GOA) and deep neural network with non‐dominated sorting genetic algorithm‐based classification approach.
Longitudinal bidirectional effects between sleep quality and internalizing problems
Authors: Vazsonyi Alexander T. , Liu Dan , Blatny Marek 
Published: March 2022

AbstractIntroductionThe current study tested the longitudinal bidirectional links between changes in sleep quality and two measures of internalizing problems, depressive and anxiety symptoms, and whether these links differed between males and females.MethodsLongitudinal data were collected from 570 early adolescents (58.6% female; Mage = 12.43 years, SD = 0.66 at Time 1) who were assessed four times over the course of 1.5 years.ResultsCross‐lagged panel models were hypothesized and tested the bidirectional links between sleep quality and both depressive and anxiety symptoms; multigroup tests were used to test for sex differences. Sleep quality and developmental changes in sleep quality were negatively associated with developmental changes in depressive symptoms as well as anxiety symptoms over time, and vice versa. These associations did not differ between male and female early adolescents.ConclusionsStudy findings provide evidence that the relationship between poor sleep quality and depressive symptoms as well as anxiety symptoms are likely bidirectional and consistently intertwined. Clinicians might consider both problems to better guide case conceptualization and treatment.