bluuebunny/crossref_metadata_2025_split huggingface dataset:
A qualitative study of the long-term consequences and adaptation in daily life after replantation surgery at a young age
Authors: Rosberg Hans-Eric , Dahlin Lars B , Carlsson Ingela K 
Published: October 2022

Introduction Impaired functioning is seen in patients following replantation surgery to the thumb or fingers. Our aim was to explore long-term consequences and adaptation in daily life after a thumb and/or multiple finger amputation followed by replantation surgery during young age. Methods Semi-structured interviews were conducted with nine recruited individuals and analysed using content analysis. The participants were asked to describe their hand function, pain, appearance, emotional consequences, impact on daily life and strategies for overcoming daily challenges. Results The interviews revealed five main categories: memories of the injury and concerns for the future; hand function, pain and cold sensitivity; feelings about having a visibly different hand; adaptation to impairments and challenges in daily life; and key messages to healthcare professions and advice to future patients. The circumstances of the injury were well remembered. Pain at rest was rare but occurred when grasping. Cold sensitivity was a major issue. Appearance-related concerns varied from none to a major problem. Despite impaired hand function, solutions were found to challenges in daily life. Compensatory strategies, personal resources and support from others were important in this adaptation process. Conclusions Patients with replantation surgery after an amputation during young age adapt to challenges in daily life over time. Healthcare professionals should offer adequate support to enable emotional processing of trauma experience. Appearance-related concerns should be addressed to prevent distress. Information about alleviating strategies to overcome long-term problems with cold sensitivity should be emphasized.
The right of a platform worker to decide whether and when to work: An obstacle to their employee status?
Authors: Rosin Annika 
Published: October 2022

The employment status of platform workers has been vividly discussed in recent years. Digital platforms often argue that the workers’ freedom to decide whether and when to work speaks to their self-employment. The scarce case law of the Court of Justice of the European Union (CJEU) as well as the new proposal for a Directive on platform work appears to indicate that opinion is shared. However, the Member States can guarantee better protection to platform workers. The working arrangements of platform workers are similar to zero-hours work in which the worker also has the right to refuse offered tasks. In some countries, such as Finland, zero-hours workers are explicitly considered as employees. Nevertheless, the general definition of the employment contract requires the commitment on behalf of the employee to perform work. This contradiction makes the employment status of zero-hours workers as well as platform workers unclear. In this article I analyse whether and how the right to decide whether and when to work affects the employment status of food delivery couriers working through digital platforms. I use Wolt and Foodora as examples. The issue is analysed in the light of Finnish regulation and European Union law. I argue that even though the case law of the CJEU and the proposal for a Directive on platform work regard the right of a food delivery courier to decide whether and when to work as evidence against their employee status, the couriers can obtain this status through the regulation of zero-hours contracts. Regardless of the fact that generally the conclusion of an employment contract requires the commitment on behalf of the worker to perform work, zero-hours workers are explicitly and exceptionally exempted from this requirement. As the couriers can be classified as zero-hours workers, their freedom to choose whether and when to work does not preclude their classification as employees.
Risk factors of aortic regurgitation progression in Chinese patients with Takayasu’s arteritis: a prospective cohort study
Authors: Wang Yujiao , Ma Lili , Sun Ying , Yu Wensu , Wu Sifan , Chen Huiyong , Dai Xiaomin , Ma Lingying , Jiang Lindi 
Published: October 2022

Objective: To elucidate the 3-year follow-up outcomes and risk factors associated with aortic regurgitation progression in Takayasu’s arteritis (TAK). Methods: This study was a prospective cohort study conducted among 77 patients with TAK at Zhongshan Hospital, Fudan University, China. All the participants were followed up and assessed with echocardiography for 3 years, and the baseline characteristics and dynamic changes in the aortic valve were recorded and investigated. A multivariable Cox model was used to explore the risk factors for aortic regurgitation progression. Results: The median onset age was 36.9 (26.0–44.4) years, and 57 patients (74.0%) were females. Fifty patients (64.9%) complained of aortic regurgitation, which was the most common valvular lesion at baseline. During the 3-year follow-up period, the progression of aortic regurgitation was observed in 29 (37.7%) patients with TAK. The progression group had higher baseline erythrocyte sedimentation rate (ESR; p = 0.013) and interleukin (IL)-6 ( p = 0.029) levels and lower early treatment remission rates ( p = 0.024). According to the Cox model, the elevated baseline IL-6 level [>13 pg/ml, hazard ratio (HR) = 2.4, 95% confidence interval (CI) = 1.0–5.8, p = 0.042] and absence of early treatment remission (HR = 3.3, 95% CI = 1.3–8.2, p = 0.010) were the independent risk factors for aortic regurgitation deterioration. Conclusion: About one-third of patients with TAK experienced aortic regurgitation progression within 3 years from first admission. Elevated IL-6 levels at baseline and absence of early treatment remission were the two important risk factors for subsequent aortic regurgitation progression.
Effectiveness of a stepped-care programme of internet-based psychological interventions for healthcare workers with psychological distress: Study protocol for the RESPOND healthcare workers randomised controlled trial
Authors: Mediavilla Roberto , McGreevy Kerry R , Felez-Nobrega Mireia , Monistrol-Mula Anna , Bravo-Ortiz María-Fe , Bayón Carmen , Rodríguez-Vega Beatriz , Nicaise Pablo , Delaire Audrey , Sijbrandij Marit , Witteveen Anke B. , Purgato Marianna , Barbui Corrado , Tedeschi Federico , Melchior Maria , van der Waerden Judith , McDaid David , Park A-La , Kalisch Raffael , Petri-Romão Papoula , Underhill James , Bryant Richard A. , Haro Josep Maria , Ayuso-Mateos José Luis ,   on behalf of the RESPOND Consortium
Published: October 2022

Background and aimsThe coronavirus disease 2019 pandemic has challenged health services worldwide, with a worsening of healthcare workers’ mental health within initial pandemic hotspots. In early 2022, the Omicron variant is spreading rapidly around the world. This study explores the effectiveness and cost-effectiveness of a stepped-care programme of scalable, internet-based psychological interventions for distressed health workers on self-reported anxiety and depression symptoms.MethodsWe present the study protocol for a multicentre (two sites), parallel-group (1:1 allocation ratio), analyst-blinded, superiority, randomised controlled trial. Healthcare workers with psychological distress will be allocated either to care as usual only or to care as usual plus a stepped-care programme that includes two scalable psychological interventions developed by the World Health Organization: A guided self-help stress management guide (Doing What Matters in Times of Stress) and a five-session cognitive behavioural intervention (Problem Management Plus). All participants will receive a single-session emotional support intervention, namely psychological first aid. We will include 212 participants. An intention-to-treat analysis using linear mixed models will be conducted to explore the programme's effect on anxiety and depression symptoms, as measured by the Patient Health Questionnaire – Anxiety and Depression Scale summary score at 21 weeks from baseline. Secondary outcomes include post-traumatic stress disorder symptoms, resilience, quality of life, cost impact and cost-effectiveness.ConclusionsThis study is the first randomised trial that combines two World Health Organization psychological interventions tailored for health workers into one stepped-care programme. Results will inform occupational and mental health prevention, treatment, and recovery strategies.Registration detailsClinicalTrials.gov Identifier: NCT04980326.
Diagnostic yield and safety of transbronchial lung cryobiopsy and surgical lung biopsy in interstitial lung diseases: a systematic review and meta-analysis
Authors: Rodrigues Inês , Estêvão Gomes Ricardo , Coutinho Lígia Maria , Rego Maria Teresa , Machado Firmino , Morais António , Novais Bastos Helder 
Published: October 2022

Introduction:Transbronchial lung cryobiopsy (TBLC) is increasingly being used as an alternative to video-assisted thoracoscopic surgery (VATS) biopsy to establish the histopathologic pattern in interstitial lung disease (ILD).Methods:A systematic literature search of the PubMed and Embase databases, from October 2010 to October 2020, was conducted to identify studies that reported on diagnostic yield or safety of VATS or TBLC in the diagnosis of ILD.Results:43 studies were included. 23 evaluated the diagnostic yield of TBLC after multidisciplinary discussion, with a pooled diagnostic yield of 76.8% (95% confidence interval (CI) 70.6–82.1), rising to 80.7% in centres that performed ≥70 TBLC. 10 studies assessed the use of VATS and the pooled diagnostic yield was 93.5% (95% CI 88.3–96.5). In TBLC, pooled incidences of complications were 9.9% (95% CI 6.8–14.3) for significant bleeding (6.9% for centres with ≥70 TBLC), 5.6% (95% CI 3.8–8.2) for pneumothorax treated with a chest tube and 1.4% (95% CI 0.9–2.2) for acute exacerbation of ILD after TBLC. The mortality rates were 0.6% and 1.7% for TBLC and VATS, respectively.Conclusions:TBLC has a fairly good diagnostic yield, an acceptable safety profile and a lower mortality rate than VATS. The best results are obtained from more experienced centres.
Clostridium myonecrosis — a rare and underdiagnosed condition in the elderly: a case with severe skipping lesions and an overview of treatment guidelines
Authors: Van Asbroeck Ellen , Vasileiadou Ourania , De Laere Sylvie , Van Hedent Eddy , Devue Katleen 
Published: October 2022

AbstractWe present an unusual and severe case of spontaneous clostridial myonecrosis (SCM) in an elderly patient, with severe skipping lesions spread throughout the body. CT imaging, combined with postmortem available blood cultures, confirmed the diagnosis. We noted an underrepresentation of SCM in the cohort of elderly patients (≥ 85 years), upon a review of case reports in the literature over the last decade. Given the worldwide demographic change resulting in an increase in the number of visits to emergency departments for this age group, it is likely that SCM is underdiagnosed in these elderly patients. This case report aims to increase awareness among emergency physicians to recognize the disease as well as to provide a treatment guideline, in order to provide better care and outcome.
Design and validation of a 63K genome-wide SNP-genotyping platform for caribou/reindeer (Rangifer tarandus)
Authors: Carrier Alexandra , Prunier Julien , Poisson William , Trottier-Lavoie Mallorie , Gilbert Isabelle , Cavedon Maria , Pokharel Kisun , Kantanen Juha , Musiani Marco , Côté Steeve D. , Albert Vicky , Taillon Joëlle , Bourret Vincent , Droit Arnaud , Robert Claude 
Published: October 2022

Abstract
Background
Development of large single nucleotide polymorphism (SNP) arrays can make genomic data promptly available for conservation problematic. Medium and high-density panels can be designed with sufficient coverage to offer a genome-wide perspective and the generated genotypes can be used to assess different genetic metrics related to population structure, relatedness, or inbreeding. SNP genotyping could also permit sexing samples with unknown associated metadata as it is often the case when using non-invasive sampling methods favored for endangered species. Genome sequencing of wild species provides the necessary information to design such SNP arrays. We report here the development of a SNP-array for endangered Rangifer tarandus using a multi-platform sequencing approach from animals found in diverse populations representing the entire circumpolar distribution of the species.

Results
From a very large comprehensive catalog of SNPs detected over the entire sample set (N = 894), a total of 63,336 SNPs were selected. SNP selection accounted for SNPs evenly distributed across the entire genome (~ every 50Kb) with known minor alleles across populations world-wide. In addition, a subset of SNPs was selected to represent rare and local alleles found in Eastern Canada which could be used for ecotype and population assignments - information urgently needed for conservation planning. In addition, heterozygosity from SNPs located in the X-chromosome and genotyping call-rate of SNPs located into the SRY gene of the Y-chromosome yielded an accurate and robust sexing assessment. All SNPs were validated using a high-throughput SNP-genotyping chip.

Conclusion
This design is now integrated into the first genome-wide commercially available genotyping platform for Rangifer tarandus. This platform would pave the way to future genomic investigation of populations for this endangered species, including estimation of genetic diversity parameters, population assignments, as well as animal sexing from genetic SNP data for non-invasive samples.
BLNIMDA: identifying miRNA-disease associations based on weighted bi-level network
Authors: Shang Junliang , Yang Yi , Li Feng , Guan Boxin , Liu Jin-Xing , Sun Yan 
Published: October 2022

AbstractBackgroundMicroRNAs (miRNAs) have been confirmed to be inextricably linked to the emergence of human complex diseases. The identification of the disease-related miRNAs has gradually become a routine way to unveil the genetic mechanisms of examined disorders.MethodsIn this study, a method BLNIMDA based on a weighted bi-level network was proposed for predicting hidden associations between miRNAs and diseases. For this purpose, the known associations between miRNAs and diseases as well as integrated similarities between miRNAs and diseases are mapped into a bi-level network. Based on the developed bi-level network, the miRNA-disease associations (MDAs) are defined as strong associations, potential associations and no associations. Then, each miRNA-disease pair (MDP) is assigned two information properties according to the bidirectional information distribution strategy, i.e., associations of miRNA towards disease and vice-versa. Finally, two affinity weights for each MDP obtained from the information properties and the association type are then averaged as the final association score of the MDP. Highlights of the BLNIMDA lie in the definition of MDA types, and the introduction of affinity weights evaluation from the bidirectional information distribution strategy and defined association types, which ensure the comprehensiveness and accuracy of the final prediction score of MDAs.ResultsFive-fold cross-validation and leave-one-out cross-validation are used to evaluate the performance of the BLNIMDA. The results of the Area Under Curve show that the BLNIMDA has many advantages over the other seven selected computational methods. Furthermore, the case studies based on four common diseases and miRNAs prove that the BLNIMDA has good predictive performance.ConclusionsTherefore, the BLNIMDA is an effective method for predicting hidden MDAs.
Floral organ transcriptome in Camellia sasanqua provided insight into stamen petaloid
Authors: Fan Menglong , Li Xinlei , Zhang Ying , Wu Si , Song Zhixin , Yin Hengfu , Liu Weixin ,  Fan Zhengqi ,  Li Jiyuan 
Published: October 2022

Abstract
Background
The cultivated Camellia sasanqua forms a divergent double flower pattern, and the stamen petaloid is a vital factor in the phenomenon. However, the regulation mechanism remains largely unclear.

Results
Here, a comprehensive comparative transcriptome analysis of the wild-type, “semi-double”, “peony double”, and “rose double” was performed. The cluster analysis of global gene expression level showed petal and stamen difficulty separable in double flower. The crucial pathway and genes related to double flower patterns regulation were identified by pairwise comparisons and weighted gene coexpression network (WGCNA). Divergent genes expression, such as AUX1 and AHP, are involved in plant hormone signaling and photosynthesis, and secondary metabolites play an important role. Notably, the diversity of a petal-specific model exhibits a similar molecular signature to the stamen, containing extensin protein and PSBO1, supporting the stamen petaloid point. Moreover, the expansion of class A gene activity influenced the double flower formation, showing that the key function of gene expression was probably demolished.

Conclusions
Overall, this work confirmed the ABCE model and provided new insights for elucidating the molecular signature of double formation.
Reporting of the safety from allergic rhinitis trials registered on ClinicalTrials.gov and in publications: An observational study
Authors: Paladin Ivan , Pranić Shelly Melissa 
Published: October 2022

Abstract
Background
Incomplete and inconsistent reporting of adverse events (AEs) through multiple sources can distort impressions of the overall safety of the medical interventions examined as well as the benefit-risk relationship. We aimed to assess completed allergic rhinitis (AR) trials registered in ClinicalTrials.gov for completeness and consistency of AEs reporting comparing ClinicalTrials.gov and corresponding publications.

Methods
We retrospectively examined completed randomised controlled trials on AR registered in ClinicalTrials.gov on or after 9/27/2009 to trials updated with results on or before 12/31/2021 along with any corresponding publications. Complete reporting of AEs in ClinicalTrials.gov were summarised in tables describing AE information, and complete reporting in publications was an explicit statement of serious AE, death or other AE. Difference in completeness, number, or description of AEs between ClinicalTrials.gov and publication was classified as inconsistent reporting of AEs.

Results
There were 99 registered trials with 45 (45.5%) available publications. All published trials completely reported AEs in ClinicalTrials.gov, and 21 (46.7%) in publications (P < .001). In 43 (95.6%) publications, there was at least one inconsistency in the reporting of AEs (P < .001). 8 (17.8%) publications had different number of serious AEs (P = .003), 36 (80.0%) of other AEs (P < .001) while deaths reporting was inconsistent in 8 (57.1%) publications (P = .127).

Conclusion
The reporting of AEs from AR trials is complete in ClinicalTrials.gov and incomplete and inconsistent in corresponding publications. There is a need to improve the reporting of AEs from AR trials in corresponding publications, and thus to improve patient safety.
Shared decision making for women with uncomplicated Cystitis in Primary Care in the Netherlands: a qualitative interview study
Authors: van Horrik Tessa M.Z.X.K. , Laan Bart J. , van Seben Rosanne , Rodenburg Gerda , Heeregrave Edwin J. , Geerlings Suzanne E. 
Published: October 2022

Abstract
Background
Urinary tract infections (UTIs) are common, especially among women. Antibiotics are commonly used to treat UTIs, but might not always be necessary, for example in the case of uncomplicated UTIs such as cystitis. Shared decision making (SDM) could reduce the risk of unnecessary antibiotic prescriptions for uncomplicated cystitis. We investigated the current management and the use of SDM for uncomplicated cystitis in primary care.

Methods
We performed a qualitative semi-structured interview study among 23 women with a history of cystitis, 12 general practitioner (GP) assistants, and 12 GPs in the Netherlands from July to October 2020. All interviews were individually performed by telephone. The data were analyzed through the use of using open and axial coding.

Results
The GP assistants managed the initial diagnostics and treatment of uncomplicated cystitis in all general practices. Usually, antibiotics were considered the standard treatment of cystitis. In most general practices, SDM was not used in the treatment of uncomplicated cystitis, mainly because of a lack of time. Women reported that they valued being involved in the treatment decision-making process, but they were not always involved. Further, both GP assistants and GPs indicated that SDM would improve the care pathway of uncomplicated UTIs.

Conclusion
In our study, SDM was infrequently used to help women with uncomplicated cystitis. To reduce the use of antibiotics for uncomplicated UTIs, a tailored intervention is needed to implement SDM for the treatment of uncomplicated cystitis in primary care.
Social and private activity after retirement—substitutes or complements
Authors: Kalbarczyk Małgorzata , Łopaciuk-Gonczaryk Beata 
Published: October 2022

Abstract
Background
Commonly observed low activity of older adults harms their well-being. We perceive the retirement as a new opening that could be utilized to fulfill previously neglected needs and involve in new activities. They can be a remedy for losing the sense of life while changing the social role and getting older. This study explores trends in activity over retirement. In particular, it verifies if different post-retirement activities: 1) formal social engagement; 2) informal help given outside the household; 3) solitary leisure or self-development activities, and 4) sociable leisure or self-development activities are mutually exclusive or supportive of each other.

Methods
We use the data from 4 and 6th wave of Survey of Health, Ageing and Retirement in Europe, taking into consideration 2757 respondents who participated in both waves. We analyze trends in activity over retirement and verify the hypotheses regarding the relationships between engaging into different types of activities and between the activity and development of personal social networks. We conduct the descriptive analysis and utilize the Generalized Structural Equation Model.

Results
Most people do not change their involvement in different activities after retirement. Among those who change, the average trend is upward. We find support that different types of activities undertaken after retirement do not crowd out each other. On the contrary, being active in one sphere goes hand in hand with activity in another. We give evidence for presence of social network mechanisms that enhance such understood complementarity. Maintaining social relationships correlates with engagement in socially-oriented activities and privately-oriented sociable pastimes. Being active, with exception of solitary forms of recreation, creates an opportunity to foster relations with other people and, thanks to their encouragement, to engage in new activities.

Conclusions
The small change in activity after retirement signifies the need to encourage non-work activity during earlier stages of life. As different types of post-retirement activities are complementary, the most active group of older adults would be the most open for social engagement and volunteering, however the least active group needs the biggest support to involve in any activities.