bluuebunny/crossref_metadata_2025_split huggingface dataset:
Emergency contraception in the iPLEDGE program: A cross‐sectional survey of pediatric dermatology provider understanding and practice
Authors: Smiley Catherine E. , Butt Melissa , Zaenglein Andrea L. 
Published: August 2022

AbstractFor patients with acne treated with the teratogen isotretinoin, emergency contraception (EC) is the only recourse when abstinence fails or effective contraception is not properly used. The purpose of this study was to evaluate the current understanding and provision of EC among pediatric dermatology providers. The survey found that 37% (21/57) of providers indicated they were at least somewhat confident in their understanding of EC. 7% (4/57) of providers agreed/strongly agreed that they provided EC counseling to all patients of reproductive potential at their initial visit and 3.5% (2/57) agreed/strongly agreed that they provide EC counseling at follow‐up visits. Our survey results suggest the need for improved EC education for pediatric dermatology providers and subsequent counseling for patients of reproductive potential on isotretinoin therapy.
Correlation between Objective Measures of Sun Exposure and Self‐Reported Sun Protective Behavior and Attitudes in Predominantly Hispanic Youth
Authors: Cole Sarah E. , Hawkins Makenzie , Miller Kimberly A. , Allen Martin W. , Cockburn Myles 
Published: August 2022

ABSTRACTMelanoma incidence is increasing, with poor prognosis cases growing faster in California Hispanics than in non‐Hispanic whites. Ultraviolet Radiation (UVR) exposure as a child has been found to disproportionately increase the risk of melanoma. To determine correlates of UVR exposure in this high‐risk population, we conducted a study in predominately Hispanic 4th and 5th grade classrooms in Los Angeles County, a high UVR environment, during the spring. To address potential reporting bias, electronic UV dosimeters were utilized to objectively measure the association between UVR exposure and constructs (acculturation, sun protective behavior and knowledge, family interventions) obtained on baseline questionnaires (n = 125). Tanning attitude (wanting to get a tan) was associated with lower median time spent outside (1.73 min versus 22.17, AUC 82.08, Sensitivity 0.78, Specificity 0.73) and standard erythemal dose (SED) on weekends, but positively associated with sun protective knowledge. Sun protective knowledge and family discussion of sunscreen were also inversely associated with objectively measured time outside. Students spent a median 30.61 (IQR 19.88) minutes outside per day (SED 0.30, IQR 0.20), with only 35.70% of it occurring in nonschool hours. We determined the majority of UVR exposure in this population occurs at school, providing valuable guidance for future interventions.
Root rot pathogens of Cinnamomum cassia in Vietnam
Authors: Dang Quynh N. , Burgess Treena I. , McComb Jen , Pham Thu Q. , Le Binh V. , Nguyen Thu H. , Le Xuan T. , Hardy Giles E. StJ. 
Published: July 2022

AbstractA study was conducted to determine the pathogens causing root rot, wilt and dieback disease of Cinnamomum cassia (Chinese cinnamon or cassia) in Vietnam, in nurseries and plantations in the Yen Bai, Quang Ninh, Thanh Hoa and Quang Nam provinces, and streams in the Yen Bai province. Pathogens were identified using morphology and internal transcribed spacer (ITS) sequence analysis. The 204 isolates obtained included 125 Phytophthora isolates and 79 from other oomycete genera. There were 112 isolates of P. cinnamomi, four P. heveae, two P. virginiana, three P. multibullata and four P. × vanyenensis. The pathogenicity and virulence of 16 P. cinnamomi, two P. heveae, two P. multibullata and four P. × vanyenensis isolates were assessed using lesion size after under‐bark inoculation of C. cassia stems, and root damage following inoculation of 4‐month‐old C. cassia seedlings. The most virulent isolate from both assessments was a P. cinnamomi from the Quang Nam plantation. Isolates of P. cinnamomi showed a wide range of virulence, with isolates from healthy trees or seedlings showing the lowest virulence. Isolates of P. × vanyenensis, P. multibullata and P. heveae showed moderate or low pathogenicity. This study showed that although P. cinnamomi is the most common pathogen associated with dieback disease in Vietnamese C. cassia plantations, other Phytophthora species may also cause this disease. Knowledge of the presence of these soil‐ and waterborne pathogens will encourage improved soil and water hygiene in nurseries and implement measures to prevent the spread of the pathogens in plantations.
Modelling Time-Varying Rankings with Autoregressive and Score-Driven Dynamics
Authors: Holý Vladimír , Zouhar Jan 
Published: August 2022

AbstractWe develop a new statistical model to analyse time-varying ranking data. The model can be used with a large number of ranked items, accommodates exogenous time-varying covariates and partial rankings, and is estimated via the maximum likelihood in a straightforward manner. Rankings are modelled using the Plackett–Luce distribution with time-varying worth parameters that follow a mean-reverting time series process. To capture the dependence of the worth parameters on past rankings, we utilise the conditional score in the fashion of the generalised autoregressive score models. Simulation experiments show that the small-sample properties of the maximum-likelihood estimator improve rapidly with the length of the time series and suggest that statistical inference relying on conventional Hessian-based standard errors is usable even for medium-sized samples. In an empirical study, we apply the model to the results of the Ice Hockey World Championships. We also discuss applications to rankings based on underlying indices, repeated surveys and non-parametric efficiency analysis.
Performing difference, longing for ‘home’: Claiming ethnic identities to build national unity among urban Solomon Islands youth
Authors: Hicks Rachel Emerine 
Published: July 2022

AbstractSince independence, Solomon Islands schools have aimed to establish a national identity and unity among Solomon Islanders; however, ethnic ties to ‘home’ remain strong. This is particularly evident in Honiara, the densely populated and multi‐ethnic capital of Solomon Islands, when urban youth who have grown up in Honiara claim their home is in a province. This paper argues that the ‘unity in diversity’ narrative taught in schools emphasises the importance of an ethnic identity tied to one's province. As a result, students must find ways to build connections to home, even if they have spent little time there, creating a nostalgia for home. Two ways this occurs is through the dances they perform and the kastom jewellery they wear. I argue that the emphasis of their unique ethnic identities is necessary for youth to stake a claim in the multi‐ethnic urban landscape and within the panethnic identity of Solomon Islander.
Defective axonal transport of endo‐lysosomes and dense core vesicles in a Drosophila model of C9‐ALS/FTD
Authors: Sung Hyun , Lloyd Thomas E. 
Published: July 2022

AbstractA GGGGCC (G4C2) repeat expansion in the C9orf72 gene is the most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Although disruptions in axonal transport are implicated in the pathogenesis of multiple neurodegenerative diseases, the underlying mechanisms causing these defects remain unclear. Here, we performed live imaging of Drosophila motor neurons expressing expanded G4C2 repeats in third‐instar larvae and investigated the axonal transport of multiple organelles in vivo. Expression of expanded G4C2 repeats causes an increase in static axonal lysosomes, while it impairs trafficking of late endosomes (LEs) and dense core vesicles (DCVs). Surprisingly, however, axonal transport of mitochondria is unaffected in motor axons expressing expanded G4C2 repeats. Thus, our data indicate that expanded G4C2 repeat expression differentially impacts axonal transport of vesicular organelles and mitochondria in Drosophila models of C9orf72‐associated ALS/FTD.
The Medicines for Malaria Venture Malaria Box contains inhibitors of protein secretion in Plasmodium falciparum blood stage parasites
Authors: Looker Oliver , Dans Madeline G. , Bullen Hayley E. , Sleebs Brad E. , Crabb Brendan S. , Gilson Paul R. 
Published: July 2022

AbstractPlasmodium falciparum parasites which cause malaria, traffic hundreds of proteins into the red blood cells (RBCs) they infect. These exported proteins remodel their RBCs enabling host immune evasion through processes such as cytoadherence that greatly assist parasite survival. As resistance to all current antimalarial compounds is rising new compounds need to be identified and those that could inhibit parasite protein secretion and export would both rapidly reduce parasite virulence and ultimately lead to parasite death. To identify compounds that inhibit protein export we used transgenic parasites expressing an exported nanoluciferase reporter to screen the Medicines for Malaria Venture Malaria Box of 400 antimalarial compounds with mostly unknown targets. The most potent inhibitor identified in this screen was MMV396797 whose application led to export inhibition of both the reporter and endogenous exported proteins. MMV396797 mediated blockage of protein export and slowed the rigidification and cytoadherence of infected RBCs—modifications which are both mediated by parasite‐derived exported proteins. Overall, we have identified a new protein export inhibitor in P. falciparum whose target though unknown, could be developed into a future antimalarial that rapidly inhibits parasite virulence before eliminating parasites from the host.
Optogenetic approaches to therapy for inherited retinal degenerations
Authors: De Silva Samantha R. , Moore Anthony T. 
Published: July 2022

AbstractInherited retinal degenerations such as retinitis pigmentosa (RP) affect around one in 4000 people and are the leading cause of blindness in working age adults in several countries. In these typically monogenic conditions, there is progressive degeneration of photoreceptors; however, inner retinal neurons such as bipolar cells and ganglion cells remain largely structurally intact, even in end‐stage disease. Therapeutic approaches aiming to stimulate these residual cells, independent of the underlying genetic cause, could potentially restore visual function in patients with advanced vision loss, and benefit many more patients than therapies directed at the specific gene implicated in each disorder. One approach investigated for this purpose is that of optogenetics, a method of neuromodulation that utilises light to activate neurons engineered to ectopically express a light‐sensitive protein. Using gene therapy via adeno‐associated viral vectors, a range of photosensitive proteins have been expressed in remaining retinal cells in advanced retinal degeneration with in vivo studies demonstrating restoration of visual function. Developing an effective optogenetic strategy requires consideration of multiple factors, including the light‐sensitive protein that is used, the vector and method for gene delivery, and the target cell for expression because these in turn may affect the quality of vision that can be restored. Currently, at least four clinical trials are ongoing to investigate optogenetic therapies in patients, with the ultimate aim of reversing visual loss in end‐stage disease.
image
Group therapeutic singing improves clinical motor scores in persons with Parkinson’s disease
Authors: Stegemoller Elizabeth , Forsyth Emily , Patel Bhavana , Elkouzi Ahmad 
Published: August 2022

BackgroundPrevious reports suggest that group therapeutic singing (GTS) may have a positive effect on motor symptoms in persons with Parkinson’s disease (PD).ObjectiveTo determine the effect of a single session of GTS on clinical motor symptoms.MethodsClinical motor symptom assessment was completed immediately before and after 1 hour of GTS in 18 participants.ResultsA significant decrease in average scores for gait and posture and tremor, but not speech and facial expression or bradykinesia was revealed.ConclusionThese results support the notion that GTS is a beneficial adjuvant therapy for persons with PD that warrants further research.
Development and validation of an early warning score to identify COVID-19 in the emergency department based on routine laboratory tests: a multicentre case–control study
Authors: Boer Arjen-Kars , Deneer Ruben , Maas Maaike , Ammerlaan Heidi S M , van Balkom Roland H H , Thijssen Wendy A H M , Bennenbroek Sophie , Leers Mathie , Martens Remy J H , Buijs Madelon M , Kerremans Jos J , Messchaert Muriël , van Suijlen Jeroen J , van Riel Natal A W , Scharnhorst Volkher 
Published: August 2022

ObjectivesIdentifying patients with a possible SARS-CoV-2 infection in the emergency department (ED) is challenging. Symptoms differ, incidence rates vary and test capacity may be limited. As PCR-testing all ED patients is neither feasible nor effective in most centres, a rapid, objective, low-cost early warning score to triage ED patients for a possible infection is developed.DesignCase–control study.SettingSecondary and tertiary hospitals in the Netherlands.ParticipantsThe study included patients presenting to the ED with venous blood sampling from July 2019 to July 2020 (n=10 417, 279 SARS-CoV-2-positive). The temporal validation cohort covered the period from July 2020 to October 2021 (n=14 080, 1093 SARS-CoV-2-positive). The external validation cohort consisted of patients presenting to the ED of three hospitals in the Netherlands (n=12 061, 652 SARS-CoV-2-positive).Primary outcome measuresThe primary outcome was one or more positive SARS-CoV-2 PCR test results within 1 day prior to or 1 week after ED presentation.ResultsThe resulting ‘CoLab-score’ consists of 10 routine laboratory measurements and age. The score showed good discriminative ability (AUC: 0.930, 95% CI 0.909 to 0.945). The lowest CoLab-score had high sensitivity for COVID-19 (0.984, 95% CI 0.970 to 0.991; specificity: 0.411, 95% CI 0.285 to 0.520). Conversely, the highest score had high specificity (0.978, 95% CI 0.973 to 0.983; sensitivity: 0.608, 95% CI 0.522 to 0.685). The results were confirmed in temporal and external validation.ConclusionsThe CoLab-score is based on routine laboratory measurements and is available within 1 hour after presentation. Depending on the prevalence, COVID-19 may be safely ruled out in over one-third of ED presentations. Highly suspect cases can be identified regardless of presenting symptoms. The CoLab-score is continuous, in contrast to the binary outcome of lateral flow testing, and can guide PCR testing and triage ED patients.
‘Well, in dentistry the dentist is always the boss’: a multi-method exploration of which organisational characteristics of dental practices most influence the implementation of evidence-based guidance
Authors: Cassie Heather , Treweek Shaun , McKee Lorna , Ramsay Craig , Young Linda , Clarkson Jan 
Published: August 2022

ObjectiveTo investigate which organisational characteristics of primary care dental practices influence the implementation of evidence-based guidance.DesignA multimethod study set within primary care dentistry in Scotland comprising: (1) Semistructured interviews with dental teams to inform development of a self-report questionnaire exploring the translation of guidance in primary care dentistry and (2) A questionnaire-based survey and case studies exploring which organisational characteristics influence knowledge translation.ResultsInterview data identified three themes: leadership, communication and context. Survey data revealed compliance with recommendations from three topics of dental guidance to be variable, with only 41% (emergency dental care), 19% (oral health assessment and review) and 4% (drug prescribing) of respondents reporting full compliance. Analysis revealed no significant relationship between practice characteristics and compliance with emergency dental care or drug prescribing recommendations. Positive associations were observed between compliance with oral health assessment and review recommendations and having a practice manager, as well as with the type of treatment offered, with fully private practices more likely, and fully National Health Service practices less likely to comply, when compared with those offering a mixture of treatment. Synthesis of the data identified leadership and context as key drivers of guidance uptake.ConclusionsEvidence-based dental recommendations are not routinely translated into practice, with variable leadership and differing practice contexts being central to poor uptake. Guidelines should aim to tailor recommendations and implementation strategies to reflect the complexities and varying contexts that exist in primary care dentistry, thus facilitating the implementation of evidence-based guidance.
Evaluation of the ‘Talking Together’ simulation communication training for ‘goals of patient care’ conversations: a mixed-methods study in five metropolitan public hospitals in Western Australia
Authors: Brown Janie , Myers Helen , Eng Derek , Kilshaw Lucy , Abraham Jillian , Buchanan Grace , Eggimann Liz , Kelly Michelle 
Published: August 2022

IntroductionIn partnership with Cancer Council Western Australia (WA), the East Metropolitan Health Service in Perth, WA has developed a clinical simulation training programme ‘Talking Together’ using role play scenarios with trained actors as patients/carers. The aim of the training is to improve clinicians’ communication skills when having challenging conversations with patients, or their carers, in relation to goals of care in the event of clinical deterioration.Methods and analysisA multisite, longitudinal mixed-methods study will be conducted to evaluate the impact of the communication skills training programme on patient, family/carer and clinician outcomes. Methods include online surveys and interviews. The study will assess outcomes in three areas: evaluation of the ‘Talking Together’ workshops and their effect on satisfaction, confidence and integration of best practice communication skills; quality of goals of patient care conversations from the point of view of clinicians, carers and family/carers; and investigation of the nursing/allied role in goals of patient care.Ethics and disseminationThis study has received ethical approval from the Royal Perth Hospital, St John of God and Curtin University Human Research Ethics Committees. The outputs from this project will be a series of research papers and conference presentations.
Reporting quality for abstracts of randomised trials on child and adolescent depression prevention: a meta-epidemiological study on adherence to CONSORT for abstracts
Authors: Wiehn Jascha , Nonte Johanna , Prugger Christof 
Published: August 2022

ObjectivesThis study aimed to investigate adherence to Consolidated Standards of Reporting Trials (CONSORT) for abstracts in reports of randomised trials on child and adolescent depression prevention. Secondary objective was to examine factors associated with overall reporting quality.DesignMeta-epidemiological study.Data sourcesWe searched MEDLINE, EMBASE, PsycINFO, PsycArticles and CENTRAL.Eligibility criteriaTrials were eligible if the sample consisted of children and adolescents under 18 years with or without an increased risk for depression or subthreshold depression. We included reports published from 1 January 2003 to 8 August 2020 on randomised controlled trials (RCTs) and cluster randomised trials (CRTs) assessing universal, selective and indicated interventions aiming to prevent the onset of depression or reducing depressive symptoms.Data extraction and synthesisAs the primary outcome measure, we assessed for each trial abstract whether information recommended by CONSORT was adequately reported, inadequately reported or not reported. Moreover, we calculated a summative score of overall reporting quality and analysed associations with trial and journal characteristics.ResultsWe identified 169 eligible studies, 103 (61%) RCTs and 66 (39%) CRTs. Adequate reporting varied considerably across CONSORT items: while 9 out of 10 abstracts adequately reported the study objective, no abstract adequately provided information on blinding. Important adverse events or side effects were only adequately reported in one out of 169 abstracts. Summative scores for the abstracts’ overall reporting quality ranged from 17% to 83%, with a median of 40%. Scores were associated with the number of authors, abstract word count, journal impact factor, year of publication and abstract structure.ConclusionsReporting quality for abstracts of trials on child and adolescent depression prevention is suboptimal. To help health professionals make informed judgements, efforts for improving adherence to reporting guidelines for abstracts are needed.
Ice cleat distribution programmes and ice cleat use among older adults: repeated cross-sectional evidence from 63 municipal interventions in Sweden
Authors: Holmberg Robin , Gustavsson Johanna , Svensson Mikael , Bonander Carl 
Published: August 2022

IntroductionIce cleats may help prevent ice-related falls in places with icy roads, but there is limited evidence about the association between ice cleat distribution and ice cleat use. Our study examined the association between Swedish municipal distribution programmes and ice cleat use among older adults (65+ years).MethodsWe combined data on municipal ice cleat distribution programmes (n=63) with repeated cross-sectional self-reports of ice cleat use in Sweden from 2007, 2010, 2014 and 2018. Respondents (n=63 234) were classified as exposed if they lived in a municipality with a programme, belonged to an eligible age group and responded after distribution (n=2507). Dose-response was assessed using distributed ice cleat pairs per capita (mean: 0.38). Linear probability models were used to estimate probability differences in ice cleat use between exposed and unexposed respondents, adjusting for age, sex, country of birth, education, survey wave and municipality. Ineligible age groups living in programme municipalities, who should be unaffected by ice cleat distribution, were used for bias assessment.ResultsExposure to ice cleat distribution programmes was associated with 7.5 percentage points (95% CI 4.2 to 10.9) higher self-reported ice cleat use after confounding adjustment. The association was larger in municipalities that distributed one pair of ice cleats per capita (17.3 percentage points (95% CI 11.2 to 23.4)). No association was found among the ineligible age groups (−2.3 (95% CI −5.5 to 1.0)).ConclusionDistributing ice cleats to older adults may help increase their use of ice cleats in settings with icy road conditions.