bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hiccups as the first presentation of secondary adrenal insufficiency associated with advanced cervical cancer
Authors: Sawamura Toshitaka , Karashima Shigehiro , Ohmori Ai , Sawada Kei , Aono Daisuke , Kometani Mitsuhiro , Takeda Yoshiyu , Yoneda Takashi 
Published: August 2022

Summary
Hiccups are a common symptom characterized by intermittent spasmodic contraction of the diaphragm. Most hiccups are transient, but some are refractory. Patients with intractable hiccups often have abnormalities of the diaphragm, medulla oblongata, and lesions affecting nerve fibers connecting them. Moreover, electrolyte abnormalities, including hyponatremia, are frequently observed in patients with intractable hiccups. Adrenal insufficiency (AI) is one of the causes of hyponatremia. However, hiccups are not commonly the first presentation. Herein, we describe a case of a 45-year-old woman complaining of refractory hiccups. The patient was initially diagnosed with hiccups associated with cervical cancer metastasis to the liver and peritoneum. The administration of chlorpromazine did not have a beneficial effect on her hiccup. Fasting hypoglycemia and hyponatremia were later found. Her serum cortisol level was low without an elevation of adrenocorticotropic hormone level. MRI of the pituitary gland showed metastatic lesion in the pituitary gland and stalk. Thus, the patient was diagnosed with secondary AI due to cervical cancer metastasis to the pituitary gland and stalk. Administration of hydrocortisone improved her hiccups with the normalization of serum sodium level. Therefore, differential diagnosis in advanced cancer patients with hiccups should include AI-induced hyponatremia.

Learning points

Hiccups could be the first manifestation of adrenal insufficiency (AI).

Hiccups in patients with AI are often mediated by hyponatremia.

Hyponatremia is less frequent in secondary AI than in primary AI. However, hyponatremia can result from increased antidiuretic hormone due to loss of cortisol.

The differential diagnosis should include AI-induced hyponatremia if hiccups occur in patients with advanced cancer, as metastasis to adrenal gland or pituitary gland could cause AI.
El Traidor, la Infiel y el Miserable:
Authors: Hottinger-Craig Sylvia 
Published: August 2022

El Traidor, la Infiel y el Miserable: el análisis de tres tópicos sobre la traducción.
Este trabajo identifica los problemas teóricos de los estudios de traducción usando tres tópicos existentes de la misma: traductore tradittore, belles infideles y el Miserable. La traducción no dice lo que debería de decir, es traidor, porque no puede explicar toda la cultura que contiene el texto de inicio, si es bella es infiel y viceversa, y luego el traductor está condenado a la miseria tanto social como económico si seguimos los supuestos de Ortega y Gasset en su Miseria y esplendor de la traducción. También hacemos una breve descripción de las técnicas de traducción de Mona Baker y Peter Newmark. Es un estado de la cuestión de la traducción actual a nivel empírico y profesional.
Zoonotic ecotype-I of Anaplasma phagocytophilum in sympatric wildcat, pine marten and red squirrel – Short communication
Authors: Hornok Sándor , Boldogh Sándor A. , Takács Nóra , Sándor Attila D. , Tuska-Szalay Barbara 
Published: August 2022

Abstract

Anaplasma phagocytophilum is the causative agent of granulocytic anaplasmosis in humans, dogs, cats, horses and tick-borne fever in ruminants. In Europe, its main vector is the tick species Ixodes ricinus. In this study, spleen and liver samples, as well as ticks from 18 wild-living mammals (belonging to seven species) were analysed for the presence of A. phagocytophilum with molecular methods. The zoonotic ecotype-I of A. phagocytophilum was identified in a European wildcat (Felis silvestris) and its tick, a European pine marten (Martes martes) and a Eurasian red squirrel (Sciurus vulgaris). All PCR-positive samples were collected in 2019 and originated in the same geographic area. These results indicate that taxonomically diverse mammalian species can maintain the local enzootic cycle of the same genotype of A. phagocytophilum. To the best of our knowledge, this is the first report of the zoonotic variant of A. phagocytophilum in the wildcat and in the European pine marten in a broad geographical context, as well as in the red squirrel in Hungary. Since all these host species are well known for their urban and peri-urban presence, the results of this study verify their role in the synanthropic enzootic cycle of granulocytic anaplasmosis and tick-borne fever.
Öğretimi Farklılaştırmayı Güçleştiren Faktörlere İlişkin Öğretmen Algı Envanteri: Geçerlik ve Güvenirlik Çalışması
Authors: BEKLER Ömer , KOZİKOĞLU İshak 
Published: August 2022

Bu çalışmanın amacı, öğretimi farklılaştırmayı güçleştiren faktörlere ilişkin öğretmenlerin
algılarını belirlemeye yönelik bir envanter geliştirmektir. Çalışma 320 öğretmenle
gerçekleştirilmiştir. Araştırmada 5’li Likert tipi 45 maddeden oluşan envanter formu
hazırlanmıştır. Açımlayıcı Faktör Analizi sonucunda, envanterin 33 maddeden oluşan altı
faktörlü bir yapı sergilediği ve toplam varyansın %62.968'ini açıkladığı belirlenmiştir. 272
öğretmenle yapılan Doğrulayıcı Faktör Analizi sonucunda, açımlayıcı faktör analizi ile elde
edilen 33 madde ve 6 faktörlü yapının doğrulayıcı faktör analizi ile doğrulandığı saptanmıştır.
Envanterin güvenirliğini belirlemeye yönelik Cronbach Alfa değerleri; birinci faktör için 0.89,
ikinci faktör için 0.85, üçüncü faktör için 0.92, dördüncü faktör için 0.80, beşinci faktör için 0.81,
altıncı faktör için ise 0.85 olarak hesaplanmıştır. Bu değerler envanterin geçerli ve güvenilir bir
veri toplama aracı olduğunu göstermektedir.
Descripción histológica de Galleria mellonella
Authors: Garzón Marcela Gómez , León Enciso Jeannette , Parga Jefferson , Padilla Saavedra Laura Daniela , Peñuela Franco Diana , Pinzón Ruiz Carlos Esteban , Lugo Cohetato Didier Javier 
Published: August 2022

Introducción: Las larvas de Galleria mellonella están siendo utilizadas como modelo animal para estudiar enfermedades infecciosas. Para evaluar microscópicamente las interacciones huésped-patógeno in vivo se requiere un correcto procesamiento histológico de las larvas que permita obtener buenos cortes para valorar los cambios que se generan durante la infección. Los investigadores requieren conocer la histología normal de la larva para determinar si el patógeno es capaz de generar enfermedad y si los nuevos tratamientos son efectivos. Objetivo: Este estudio tuvo como objetivo presentar el procedimiento de fijación y técnica histológica de las larvas de Galleria mellonella que realizamos de rutina en el laboratorio Técnica Histológica de la FUCS y la descripción histológica de larvas normales. Métodos: Las larvas de Galleria mellonella fueron fijadas con 100 ????L de FAATD y se realizaron cortes transversales y longitudinales, que fueron procesados de manera automatizada, en el procesador de tejidos Technicon Doble modelo 2ª. Las larvas pasaron a la central de inclusión para darle una figura tridimensional al casete y finalmente a cortes finos en el micrótomo. Se realizó la coloración de Hematoxilina Eosina (H&E) y registro fotográfico. Se tomó hemolinfa, se extendió en láminas y se coloreo con Wright para registro fotográfico. Resultados: Mostramos y describimos los órganos y las estructuras normales de la larva que deben analizarse en los estudios de patogenicidad microbiana y evaluación de nuevas moléculas para tratamiento de infecciones. Conclusión: El estudio histológico presentado es una herramienta que contribuye a la implementación de Galleria mellonella como modelo animal.
Scientiﬁc and Theoretical Characteristics of the Stage of a Disciplinary Case Consideration and Decision-Making
Authors: Leshchina E. L. 
Published: August 2022

The paper is devoted to the characteristics of legal relations arising at the stage of consideration of a disciplinary case and decision-making within the framework of disciplinary proceedings brought against civil servants. The study explains the content of this stage, mental and practical operations, procedural actions undertaken to establish objective truth in an individual and specific case, the final legal assessment of the established facts and circumstances by the person in charge.The paper substantiates that a disciplinary case consideration and decision making constitutes a stage of proceedings in a disciplinary case or legal proceedings based on materials about a gross disciplinary offense that includes considering the case on the merits in order to establish factual and legal basis of the case and to make a lawful, fair and reasonable decision. The stage of consideration of the disciplinary case and decision-making involves logical and procedural activity of managers (chiefs), commanders, judges of the garrison military court aimed to establish the correspondence between the circumstances of the disciplinary case and the facts that actually took place (i.e. objective truth), to provide legal qualification of the offense by correlating the actual circumstances and elements of an offence and formulation of conclusions and adoption of decisions based on the circumstances of the case.The paper states lack of procedural norms ensuring consideration of disciplinary cases and adoption of decisions concerning application of disciplinary penalties in the public service system (with the exception of the military service system), which determines the exact and unswerving adherence by law enforcement officers to the general principles of legal and disciplinary responsibility and the established rules applied to impose disciplinary penalties. A disciplinary case consideration by an authorized person in chief is practically implemented in the study of the proceedings files, performing an internal audit, examining the protocol on gross disciplinary misconduct of a military man. This circumstance presupposes further processalization of the legal enforcement activity under consideration and its regulation by the norms of administrative procedural legislation.
Gender Inequality in Marriage and Family Sphere: Forms of Manifestation and Options for Coping with it
Authors: Mikhaylova I. A. 
Published: August 2022

Gender inequality in the marriage and family sphere is most pronounced in the different attitudes of men and women to marriage registration, because it is men who, as a rule, prefer common-law marriage, and women are forced to put up with a model of relationships outside of the marriage, which deprives her of the rights provided for legitimate spouses. The analysis of the negative consequences of this problem allowed us to propose the following. It is necessary to legislatively fix the legal consequences of a long-term cohabitation of a man and a woman for those cases when, due to the death of one of the actual spouses, the marriage cannot be registered, which will contribute to the protection of the rights and interests of the other spouse. One more form of gender inequality is the practice when, in the vast majority of cases, a marriage is dissolved and the child remains in the care of the mother. This may adversely affects the psycho-emotional state of fathers deprived of the opportunity to live with their child, and children who wanted to live with the father, and not with the mother. It is necessary to form a stable judicial position based on the unconditional equality of the rights of the child’s parents, which is why decisions on such cases should be made following a comprehensive study of all the circumstances that testify in favor of both the mother and the father. One more form of gender inequality is a violation of women’s rights. Many fathers evade the payment of alimony for the maintenance of children, which is why the mother is entrusted not only with the upbringing of the child, taking care of his health, education, development, but also with the duty of his property maintenance, the burden of which she bears alone.The results of the analysis make it possible to conclude that all these forms of gender inequality in marriage and family sphere should be investigated by not only legal science, but also psychology and sociology. It is vital as they have deep psychological, emotional and cognitive foundations that form differently in the minds of men and women and manifest themselves in different ways in their behavior.
Android software-based tinnitus retraining therapy: efficacy in treatment of refractory tinnitus
Authors: Athavale Aakriti Sanjay , Sahu Pankaj Kumar , Singh Roohie , Natraj Rashmi 
Published: August 2022

<p><strong>Background: </strong>Tinnitus is described as a perception of sound in the absence of a sound stimulus. Despite the availability of a number of management strategies, the cure for tinnitus remains elusive. Tinnitus retraining therapy (TRT) combines sound therapy with directive counselling to address subjective tinnitus. This study was done to assess the efficacy of TRT in management of subjective tinnitus that is refractory to various tinnitus treatment strategies. The objectives of this study were to assess the efficacy of Android software TRT in management of refractory tinnitus and to observe the association of hearing status on response to TRT.</p><p><strong>Methods: </strong>Observational, analytical cohort study of 51 patients undergoing smartphone-based TRT. The assessment tools included comprehensive audiometric evaluation, two self -administered questionnaires tinnitus handicap inventory (THI) and tinnitus functional index (TFI) which were assessed at baseline (0), 6 weeks and at 12 weeks of TRT.</p><p><strong>Results: </strong>Statistical data analysis revealed significant improvement in perceived severity of tinnitus following TRT, reflected by improvement of THI and TFI scores (statistically significant, p&lt;0.05). Mean pure tone average threshold was 22.1Hz. Additionally, no significant association was found between the hearing loss and the severity of tinnitus.</p><p><strong>Conclusions: </strong>There is significant improvement in self-perceived disability and severity following TRT as measured using THI and TFI. The results confirm the efficacy of TRT in management of patients with refractory tinnitus. </p>
Targeted NGS analysis of the canonical genes in 274 Indian patients with suspected myeloproliferative neoplasms: An Indian diagnostic laboratory’s perspective
Authors: Kelkar Ketki , Anand Siddharth , Somani Nikita , Ramanan Vijay , Ranade Shatakshi , Patil Kunal , Ragte-Wathare Trupti , Gangodkar Priyanka , Khatod Kavita , Agarwal Meenal 
Published: August 2022

Myeloproliferative neoplasms (MPNs) are caused by somatic pathogenic variants that stimulate increased production and clonal expansion of CD34 multipotent hematopoietic stem cells. Recent World Health Organization (WHO) diagnostic criteria for the diagnosis of Philadelphia chromosome (Ph) negative MPNs includes detection of mutations in the Janus Kinase 2 (), myeloproliferative leukemia (), and calreticulin () genes. The purpose of this study was to demonstrate the clinical utility of an in-house next-generation sequencing (NGS) assay targeting only these canonical genes for the molecular diagnosis of patients with Ph-negative MPNs. We tested 274 samples of patients clinically suspected of having Ph-negative MPNs using an in-house developed NGS panel. The assay consists of two parts, a multiplexed PCR and a highly multiplexed NGS workflow capable of handling diverse samples. The assay is capable of simultaneously detecting mutations in exons 12 and 14, exon 9, and exon 10. Of the 274 samples tested, 49 samples harbored mutations in the gene (48 for the V617F and 1 for exon 12), 31 harbored mutations in the gene, and two harbored mutations in the gene. One sample harbored a mutation each in the and genes. Here, we present the distribution of mutations in an Indian cohort of 274 patients from India with Ph-negative MPNs. Moreover, we have successfully demonstrated the clinical utility of our in-house multiplexed NGS assay for the molecular diagnosis of MPNs with varying mutation depths
A case of disseminated candidiasis in an immunocompromised patient masquerading as adrenocortical carcinoma
Authors: Nath Ambili R , Pothen Lillykutty , Jessy M M  
Published: August 2022

Disseminated fungal infection is the presence of a fungal pathogen in the blood (fungemia) and/or any other deep-seated site because of hematogenous seeding. Conditions which predispose individuals for disseminated fungal infections include renal failure, following surgical procedures, HIV, neutropenia, hematological malignancies, and long term use of antibiotics, late sepsis and total parenteral nutrition. Candida is the commonest pathogen encountered in disseminated fungal infections. Secondary seeding of the organism can occur as a result of hematogenous spread. Mortality from disseminated fungal disease is high and therefore high index of suspicion, prompt diagnosis and prompt initiation of antifungal therapy is essential this can be prevented by prophylactic medications in patients at high risk and also by definitive treatment when diagnosis is confirmed.
Primary hepatic neuroendocrine tumor with sarcoid like granulomas: A case report
Authors: Kumar Pankaj , Kumar Sunil , Vaiphei Kim , Kumar Rajender 
Published: August 2022

Primary hepatic neuroendocrine tumor (PHNET) is a rare entity comprising 0.3% of all neuroendocrine tumors. Tumors coexisting with granulomas are occasionally noted with malignancies in the lymph nodes draining the tumor or within the primary tumor itself. Tumor-related sarcoid reactions are noted only in carcinomas and its association with a NET has been extremely rare.: We report a case of PHNET in a 63-year male who presented with various comorbidities who was incidentally detected with a liver space-occupying lesion (SOL). Contrast enhanced CT scan of the abdomen revealed a well-defined exophytic mass in the liver involving segment 6. Subsequently, 68Ga DOTANOC PET/CT scanning revealed somatostatin receptor-expressing well-defined lesion measuring 5.1 x 5.0 cm in segment 6 (SUV MAX 19). A diagnosis of either a primary or a metastatic neuroendocrine tumor was made and non-anatomical wedge resection of the tumor was done with a detailed exploration of the abdominal cavity to look for a primary focus that did not reveal any other lesion or mass. Histologically, the tumor was confirmed to be a Neuroendocrine Tumor along with the presence of tumor-related sarcoid like granulomas in the adjoining hepatic parenchyma.: Diagnosis of a PHNET requires a combination of a negative abdominal survey at the time of the operative procedure, pathologic evaluation of specimen, and a negative imaging workup for extrahepatic NET in both the pre and postoperative settings.
Power-Hungry Characters in Serbian Comedy
Authors: Jevtić Trifunović Nevena 
Published: August 2022

Every literary work is a complex work of art that aspires to originality, authenticity and individuality. As a subtype of drama, comedy affects the process of shaping its actants with its attributes and conventions. Our research is based on a review of the comedies written by the Serbian writers and the unification of literary-theoretical hypothesis about power-hungry characters. The common theme of the analyzed comedies is power as the key to the transformation of comic characters and the reason for their abandonment of normal life. Power and authority lead characters to act immorally and unreasonably, and unsuccessful attempts to achieve their goal at any cost often bring their lives to the brink of meaninglessness, and make their actions tragicomic. As an outspoken opponent of bureaucrats and people who hide behind the authority and power for the sake of personal gain, Serbian writers found inspiration in the generally present human deformations. Therefore, it is completely normal and natural for the police to be corrupt and semi-literate in their comedies, just as it is completely natural and normal for voters to be bribed before the parliamentary elections, and for private and personal life to become an arena of political struggle for the sake of small goals. The reason for choosing their comedies was affected by the fact that the humor is alive, present, and popular even today as it was during their lifetime. Healthy and eternally young laughter, colorful characters, comic portrayal of human and social flaws (petty-bourgeois mentality, selfishness, love of power, false morals, flattery, snobbery) are the features of their literary works that make them contemporary at any time.
Слово об Учeном и Учителе: к 95-летию Профессора Леонида Михайловича Васильева
Authors: Пятаева Наталия 
Published: August 2022

Цель статьи – рассказать об основателе Уфимской семантической школы (Россия) профессоре Л.М. Васильеве и его Системном семантическом словаре русского языка, не имеющем аналогов в современной лексикографии.
Л.М. Васильев работал над проблемами: сущность языкового знака, семиотическая стратификация языка, языковое значение и семантические поля, методы изучения языка.
В Системном семантическом словаре русского языка представлены выделенные и структурированные автором 15 классов предикатной лексики: бытийные, оценочные, количественные, ментальные, модальные, пространственные, эмоциональные, предикаты отношения, состояния, свойства, образа жизни, звучания, движения, речи, восприятия, волевых усилий. Каждый класс состоит из макро- и микропарадигм, включающих базовые предикаты, их семантические дериваты, формы способов глагольного действия и субъективной оценки, семантические корреляты и модели предложений.
В качестве примера в статье приведена семантическая микропарадигма предикаты эстетической оценки (262 единицы), место которой в лексической системе русского языка можно показать схемой: семантический класс оценочные предикаты → три макропарадигмы модально-оценочные, общеоценочные и частнооценочные предикаты → три микропарадигмы предикаты утилитарной, этической и эстетической оценки.
В словаре показана система семантических классов русского языка, описана их структура, содержание и способы лексико-грамматической экспликации.
Теория и методика построения словаря могут быть экстраполированы на описание лексико-семантических систем других языков.