bluuebunny/crossref_metadata_2025_split huggingface dataset:
Les personnages féminins et masculins à l’épreuve du mentir-vrai dans L’Invitée de Beauvoir et L’Âge de raison de Sartre
Authors: Muller Justine 
Published: November 2022

Résumé
La lecture croisée des personnages féminins et masculins de L’Âge de raison et de L’Invitée permet de mettre en lumière la transformation que subit le matériau biographique dans ces romans de Sartre et de Beauvoir. La transposition fictionnelle du couple donne notamment lieu à des personnages stéréotypés s’offrant comme des caricatures de l’un et de l’autre qui viseraient à dénoncer certains de leurs travers. Loin d’être prisonniers des stéréotypes, les auteurs en joueraient, leurs œuvres fictionnelles rejoignant par là leur philosophie existentialiste.
A Vertically Resolved Analysis of Radiative Feedbacks on Moist Static Energy Variance in Tropical Cyclones
Authors: Zhang Bosong , Soden Brian J. , Vecchi Gabriel A. 
Published: November 2022

Abstract
A vertically resolved moist static energy (MSE) variance budget framework is used to diagnose processes associated with the development of tropical cyclones (TCs) in a general circulation model (GCM) under realistic boundary conditions. Previous studies have shown that interactions between radiation and MSE promote TC development. Here, we examine the vertical contributions of radiation and its interactions with MSE by performing several mechanism-denial experiments in which synoptic-scale radiative interactions are suppressed either in the boundary layer or in the free troposphere. Partly suppressing radiative interactions results in a reduction in global TC frequency. However, the magnitude of reduction and structure of the feedback depend on the intensity and structure of the TCs in these mechanism-denial experiments, indicating that both the magnitude and the vertical location of radiative interactions can impact global TC frequency. Using instantaneous 6-hourly outputs, an explicit computation reveals distinct spatial patterns of the advection term: the vertical component is positive in the mid- to upper troposphere, which reflects an upward transport of MSE by deep convection, whereas the horizontal component is positive in the boundary layer. These results illustrate the impact of the vertical distribution of radiative interactions and vertically varied contribution of the advection term in the development of TCs.
The impact of low-salt bread as a simple diet on hypertensive patients with cardiovascular comorbidities
Authors: Berrichi Moustafa , Berrichi Meryem , Abdat Bey-Omar Nadira , Ferouani Wafaa , Haddouche Manel 
Published: November 2022

Objectives During recent years, hypertension and related cardiovascular complications have become the leading health challenges of this century. Non-pharmacologic strategies, emphasizing mainly salt restriction and physical activity, are recommended for all patients with hypertension. Our objective was to assess the impact of low salt white bread intake, widely consumed in Western Algeria, on blood pressure values in hypertensive patients with and without comorbidities. Materials and methods 134 hypertensive patients (male  =  78, female  =  56) were included. The study population was divided into two groups according to their choice of following a low salt white bread diet or not. Their dietary salt intake and physical activity were surveyed along with their blood pressure measurements and associated comorbidities. Other clinical and anthropometric data were collected. Results Patients following low salt bread diet showed decreased systolic and diastolic blood pressure values (119.07/74.63 mmHg) compared to the second group (131.92/79.81) ( p  < 0.01). These results were observed specifically in patients with adjacent cardiovascular diseases who seem to be less compliant to the diet (41.1% of the whole population, p < 0.05) and show significant increased blood pressure (135.75/81.53 mmHg) compared to compliant patients (116.66/75.33 mmHg) ( p  < 0.01). Conclusion The study highlights the impact of low salt bread diet on the treatment of hypertension with and without comorbidities.
Virtual reality augments effectiveness of treadmill walking training in patients with walking and balance impairments: A systematic review and meta-analysis of randomized controlled trials
Authors: Hao Jie , Buster Thad W , Cesar Guilherme M , Burnfield Judith M 
Published: November 2022

Objective To systematically summarize and examine current evidence regarding the combination of virtual reality and treadmill training in patients with walking and balance impairments. Data sources English language randomized controlled trials, participants with walking and balance impairments, intervention group used virtual reality and treadmill, control group only used treadmill with the same training frequency and number of sessions. Six bioscience and engineering databases were searched. Methods Two independent reviewers conducted study selection, data extraction, and quality assessment. Methodological quality was assessed using the Physiotherapy Evidence Database (PEDro) scale. Results Sixteen randomized controlled trials including 829 participants were identified. Compared to treadmill-only training, virtual reality augmented treadmill training induced significantly faster walking ( p < 0.001; standardized mean difference (SMD) = 0.55, 95%CI: 0.30 to 0.81), longer step length ( p < 0.001; SMD = 0.74, 95%CI: 0.42 to 1.06), narrower step width ( p = 0.03; SMD = −0.52, 95%CI: −0.97 to −0.06), longer single leg stance period ( p = 0.003; SMD = 0.77, 95%CI: 0.27 to 1.27), better functional mobility ( p = 0.003; SMD = −0.44, 95%CI: − 0.74 to −0.15), improved balance function ( p = 0.04; SMD = 0.24, 95%CI: 0.01 to 0.47), and enhanced balance confidence ( p = 0.03; SMD = 0.73, 95%CI: 0.08 to 1.37). Walking endurance did not differ significantly between groups ( p = 0.21; SMD = 0.13, 95%CI: −0.07 to 0.34). Conclusions Virtual reality augmented treadmill walking training enhances outcomes compared to treadmill-only training in patients with walking and balance impairments. The results of this review support the clinical significance of combining virtual reality with treadmill training with level 1A empirical evidence.
A Case Report of Hypertriglyceridemia-Associated Acute Pancreatitis Following Use of Brazil Nut Weight-Loss Supplement
Authors: Von Ruden Serena , Slusarenko Natalie , Webster Daniel 
Published: November 2022

Purpose: Brazil nuts ( Bertholletia excelsa) are consumed world-wide and have become a new trend in weight loss supplementation. We present a unique case of severe hypertriglyceridemia-associated acute pancreatitis following daily usage of a Brazil nut supplement product. Summary: A Hispanic female presented with severe hypertriglyceridemia and acute pancreatitis several months after starting a Brazil nut weight loss supplement in the setting of poorly controlled Type 2 Diabetes Mellitus. Her initial triglyceride level was undetectably high >10,000 mg/dL but improved rapidly following euglycemic insulin infusion and supplement cessation. The patient was managed with supportive care, started on oral fibrate therapy after abdominal symptoms improved, and was discharged to home in stable condition. Conclusion: It is essential for pharmacists to maintain a high index of suspicion for patients taking complementary and alternative medications and supplements who present with acutely altered laboratory parameters or onset of acute disease. In this instance, a patient was found to have profound hypertriglyceridemia with onset of acute pancreatitis following usage of a Brazil nut weight loss supplement.
Complications, Reoperations, and Patient-Reported Outcomes Following a 2-Stage Revision Total Ankle Arthroplasty for Chronic Periprosthetic Joint Infections
Authors: Conti Matthew S. , Irwin Todd A. , Ford Samuel E. , Jones Carroll P. , Anderson Robert B. , Davis W. Hodges 
Published: November 2022

Background: As total ankle arthroplasty (TAA) becomes more common, chronic periprosthetic joint infections (PJIs) will be encountered more frequently. No studies have reported on patient-reported outcomes following a 2-stage revision procedure for a chronic PJI after a TAA. The primary purpose of this study was to investigate postoperative clinical outcomes at a minimum of 2 years following a 2-stage revision TAA for chronic PJI. Methods: Patients who underwent a 2-stage revision TAA for a chronic PJI (>4 weeks after a primary TAA) between January 2010 and December 2019 were eligible to be included in this study. Chronic PJI was defined as a sinus tract that directly communicated with the prosthesis or the same organism identified in ≥2 synovial fluid samples. Twelve patients were eligible to be included in this case series. One patient died prior to 2-year follow-up, which left 11 patients available for analysis. All 11 patients underwent reimplantation. The data were found not to be normally distributed; therefore, medians and interquartile ranges (IQRs) were reported. Results: At a median of 3.0 years (IQR 2.0-4.0 years) following the second stage of their revision arthroplasty, the median Foot and Ankle Ability Measure (FAAM) Activities of Daily Living and Sports scores were 60.7 (IQR 52.4, 79.8) and 31.3 (IQR 9.4, 40.6), respectively. At final follow-up, 10 patients (90.9%) were ambulating with a TAA in place. Seven patients (63.6%) required a reoperation including 1 patient who underwent a below-knee amputation. Conclusion: Our study suggests that a 2-stage revision TAA may be an option for patients with a chronic PJI. However, patients who undergo a 2-stage revision TAA for a chronic PJI have lower than previously published 2-year FAAM scores and a high rate of reoperation. Level of Evidence: Level IV, case series.
The effect of domiciliary high flow nasal cannula treatment on dyspnea and walking distance in patients with interstitial lung disease – A pilot study
Authors: Weinreich Ulla Møller , Burchardt Charlotte , Huremovic Jasmina 
Published: November 2022

Introduction Interstitial Lung Diseases (ILD) affect the lung parenchyma and are often complicated by respiratory failure (RF) and impaired physical activity. High Flow Nasal Cannula (HFNC) has proved effective in other disease entities with RF. The aim of this study is to investigate the effect of domiciliary HFNC in ILD on dyspnea and walking distance. Methods A 6 weeks cross-over study with domiciliary HFNC-treatment/6 weeks’ observation in ILD-patients requiring ambulatory oxygen therapy or with newly prescribed (within 12 months) long term oxygen therapy. Patients were advised to use HFNC 8 h/day, recommended night-time use. Body phletysmography; 6-min walk test (6MWT) including BORG-score, oxygen saturation (SO2) at start, minimum SO2 and time to recovery after 6MWT; arterial blood gasses; modified Medical Research Council (mMRC)-score; quality of life, by the St George Respiratory Questionnaire (SGRQ) and QoS, by the Richards-Campbell Sleep Questionnaire (RCSQ) were investigated at baseline; six weeks and 12 weeks. Results 10 patients were included; one later withdrew consent. Patients used HFNC between 8-<1 h/day. There were no differences in lung function; blood gasses; SGRQ or RCSQ over the observational period). Walking distance improved significantly (393–441 m p = 0.049) as did time to recovery (3.4–2-2 min, p = 0.001). When correcting for HFNC use (hours/day) significant improvement was also seen in mMRC-score ( p = 0.035) and minimum saturation during 6MWT ( p = 0.01). Conclusion Despite a very heterogenous group and no effect on quality of life and -sleep, the study indicates an improvement in dyspnea and physical ability of HFNC in ILD patients.
Comorbidity and risk factors of subsequent lower extremity amputation in patients diagnosed with diabetes in Saskatchewan, Canada
Authors: Essien Samuel Kwaku , Zucker-Levin Audrey 
Published: November 2022

Objective Subsequent limb amputation (SLA) may be necessary due to disease progression, infection, or to aid prosthesis fit. SLA in Saskatchewan has increased 3.2% from 2006 to 2019 with minor SLA increasing 9.6% during that period. Diabetes affects a large proportion of patients who require SLA; however, the impact of additional comorbidities is not clear. Methods First-episode subsequent lower extremity limb amputation (SLEA) cases with the presence/absence of diabetes, other comorbidities, and demographic characteristics from 2006–2019 were retrieved from Saskatchewan's Discharge Abstract Database. Logistic regression was performed to examine the magnitude of the odds of SLEA. Results Among the 956 first-episode SLEA patients investigated, 78.8% were diagnosed with diabetes. Of these, 76.1% were male and 83.0% were aged 50 + years. Three comorbidities: renal failure (AOR = 1.9, 95% Cl 1.1 − 3.0), hypertension (AOR = 3.0, 95% Cl 2.0 − 4.5), and congestive heart failure (AOR = 2.0, 95% CI 1.2 − 3.2), conferred the highest odds of SLEA. The odds of SLEA is greatest for those aged 50–69 years, males, Registered Indians, and associated with a prolonged hospital stay. Discussion These data are important as they may help medical providers identify patients at the highest risk of SLEA and target interventions to optimize outcomes.
Perceptions of Concussion and Associated Anxiety in Irish Collegiate Athletes
Authors: O’Connor Siobhán , Geaney Deirdre , Whyte Enda F. , Kontos Anthony P. , O’Halloran Philip J. , Beidler Erica 
Published: November 2022

Background: Concussion nondisclosure and poor management after a concussion are a concern in Irish collegiate sports. How athletes perceive concussions and appraise their own concussion may affect their decisions and behaviors after a suspected concussion. However, this has yet to be examined in an Irish context. This study aimed to (1) establish concussion perceptions and associated anxiety in Irish collegiate athletes; (2) examine how sex, concussion, and mood disorder history influenced their perceptions; and (3) investigate factors associated with higher anxiety perceptions. Hypothesis: Irish collegiate athletes will display negative concussion perceptions and anxiety related to concussion, especially in female athletes and those without a concussion history. Study Design: Cross-sectional study. Level of Evidence: Level 3. Methods: Irish collegiate athletes [n = 268 (141 women,127 men), mean age = 21.5 ± 2.2 years] from high-risk sports completed a survey including the Perceptions of Concussion Inventory for Athletes (PCI-A), demographics, diagnosed concussion history, self-reported mood disorder history, and a concussion knowledge assessment. Differences in concussion perceptions by sex, concussion history, mood disorder history were examined using Mann-Whitney U tests, and factors associated with anxiety-related concussion perceptions were identified using multivariate logistic regression. Results: Over half (53.0%, n = 142) of participants reported concerns regarding concussion. The thoughts of sustaining a concussion made participants feel upset (63.4%, n = 170), fearful (47.7%, n = 128), and anxious (35.1%, n = 94). Women reported significantly higher anxiety ( P < 0.01, r = 0.23), effects ( P = 0.04, r = 0.12), and clarity ( P = 0.01, r = 0.16) perception scores. Participants with a diagnosed concussion history displayed greater symptom variability perception scores ( P = 0.04, r = 0.12), but lower anxiety ( P = 0.03, r = 0.13) and treatment ( P < 0.01, r = 0.19) beliefs on the PCI-A. No differences were observed for those with a history of a mood disorder ( P > 0.05). A significant multivariate model was established (χ2 = 55.44, P < 0.01), with female sex [odds ratio (OR) = 1.53], concussion history (OR = 0.63), effects (OR = 1.31), and treatment (OR = 1.15) subscales associated with greater anxiety. Conclusion: Concerns about sustaining a concussion are prevalent in Irish collegiate athletes. Women displayed more negative perceptions and those with a concussion history displayed fewer perceived benefits of treatment. Clinical Relevance: The findings support the need for concussion awareness campaigns to provide accurate concussion information to mitigate anxiety-related concussion perceptions and injury belief misconceptions.
Integrated bioinformatics analysis reveals novel key biomarkers in diabetic nephropathy
Authors: Joshi Harish , Vastrad Basavaraj , Joshi Nidhi , Vastrad Chanabasayya 
Published: November 2022

Objectives: The underlying molecular mechanisms of diabetic nephropathy have yet not been investigated clearly. In this investigation, we aimed to identify key genes involved in the pathogenesis and prognosis of diabetic nephropathy. Methods: We downloaded next-generation sequencing data set GSE142025 from Gene Expression Omnibus database having 28 diabetic nephropathy samples and nine normal control samples. The differentially expressed genes between diabetic nephropathy and normal control samples were analyzed. Biological function analysis of the differentially expressed genes was enriched by Gene Ontology and REACTOME pathways. Then, we established the protein–protein interaction network, modules, miRNA-differentially expressed gene regulatory network and transcription factor-differentially expressed gene regulatory network. Hub genes were validated by using receiver operating characteristic curve analysis. Results: A total of 549 differentially expressed genes were detected including 275 upregulated and 274 downregulated genes. The biological process analysis of functional enrichment showed that these differentially expressed genes were mainly enriched in cell activation, integral component of plasma membrane, lipid binding, and biological oxidations. Analyzing the protein–protein interaction network, miRNA-differentially expressed gene regulatory network and transcription factor-differentially expressed gene regulatory network, we screened hub genes MDFI, LCK, BTK, IRF4, PRKCB, EGR1, JUN, FOS, ALB, and NR4A1 by the Cytoscape software. The receiver operating characteristic curve analysis confirmed that hub genes were of diagnostic value. Conclusions: Taken above, using integrated bioinformatics analysis, we have identified key genes and pathways in diabetic nephropathy, which could improve our understanding of the cause and underlying molecular events, and these key genes and pathways might be therapeutic targets for diabetic nephropathy.
Studying in vivo and in vitro effects of a novel polyvinyl benzyl chloride-D-glucaro-1, 4-lactonate polymer-coated bile duct stent for anti-biliary mud deposition
Authors: Zhang Weixing , Kanwal Fariha , Batool Aima Iram , Mustaqeem Muhammad , Rehman Muhammad Fayyaz ur , Wan Xinjian 
Published: November 2022

Background: We aim to coat a novel polyvinyl benzyl chloride-D-glucaro-1, 4-lactonate polymer-coated bile duct stent for anti-biliary mud deposition and investigate its in vivo and in vitro impacts. Biliary mud deposition is a leading cause of plastic biliary stent obstruction after its placement. Orally administrated D-glucaro-1, 4-lactonate is a specific competitive inhibitor of β-glucuronidase that causes biliary mud deposition. Methods: In this study, the stents coated with polyvinyl benzyl chloride-D-glucaro-1,4-lactonate polymer (PVBC-DGL) were placed in an ex vivo bile duct model perfused with porcine bile and observed every week until completely blocked. Post establishing the model of bile duct stenosis in piglets, stents are observed through endoscopy, hematology, patency time, and pathological changes within 6 months. Results: The 70% PVBC-DGL stents achieved the highest percentage of the inhibitory effect when the drugs were completely released in vitro. Results were obtained from 14 pigs (5: no coating (original), 4: 0% coating, and 5: 70% coating). The overall patency time of the stents was prolonged in all groups; however, the group with 70% coated stents showed a significantly prolonged patency time as compared to no coating (original) and the 0% coating groups in pigs (23.4 ± 1.8 vs 11.2 ± 2.1 w ( p = 0.05); 23.4 ± 1.8 vs 10.5 ± 2.5 w ( p = 0.05), respectively). Conclusion: The stents with 70% PVBC-DGL better prevent and control the deposition of bile mud and prolong the patency time of stent placement in the subject animals and may be proposed for further clinical trials in patients.
Role of Lateral Soft Tissue Release in Percutaneous Hallux Valgus Surgery: A Systematic Review of the Literature
Authors: Bernasconi Alessio , Izzo Antonio , Vallefuoco Salvatore , Basso Morena A. , Marasco Domenico , Mariconda Massimo , Lintz Francois , Smeraglia Francesco 
Published: November 2022

Category: Bunion; Midfoot/Forefoot Introduction/Purpose: The utility of Lateral soft tissue release (LSTR) in the setting of percutaneous Hallux Valgus (PHV) surgery is still debated. Our aim was to conduct a systematic review of the literature comparing the results of PHV surgery with and without LSTR in order to define the benefits and risks related to this procedure. Our hypotheses were that LSTR would 1) reduce the risk or recurrence of the deformity without increasing the risk of complication and 2) lead to an improved clinical outcome with greater radiological correction. Methods: This systematic review followed the PRISMA checklist and was prospectively registered in the Prospero database (CRD4202230). Pubmed, Embase, Cochrane Library and Scopus were used to identify clinical papers reporting results after PHV surgery. Studies were pooled in two categories: PHV with LSTR (Group 1 or G1) and PHV without LSTR (Group 2 or G2). Data regarding the study design, demographics, the surgical procedure and the clinical and radiological outcome were extracted and compared. The modified Coleman Methodology score (mCMS) was used to assess the quality of studies included. Results: Sixteen studies were selected (G1:594 feet;G2:553 feet). The sample size (p=0.11), sex distribution (p=0.57), length of follow-up (p=0.79), size of the incision (p=0.13) were comparable. Studies in G2 included a younger population (54+-6.3 vs 44.4+- 6.8 years;p=0.006), however age did not correlate with the clinical and radiological outcome (all p>0.05). The pooled proportion of complication in the two groups (27%, 95%CI 17-38 and 25%, 95%CI 12-37, respectively) and the pooled proportion of recurrence at a minimum 18-month follow-up (2%, 95%CI 0-3 and 2%, 95%CI 0-5, respectively) didn't differ (p=0.79 and p=0.70). The pre- (51.7+-10.6 and 45.8+-1.7 points;p=0.23) and post-operative AOFAS scores (89.4+-4.3 and 86.9+-3.2 points;p=0.16) and the pre-(HVA:29.7+-2.9 and 44.1+-26.8 degrees,p=0.23)(IMA:12.5+-4.2 and 14.1+-2.6 degrees;p=0.94) and post-operative radiological angles (HVA:12.1+-4.3 and 12.3+-2.3;p=0.47)(IMA:9.2+-2.2 and 7.9+-1.3;p=0.2) didn't differ in the two groups. The methodological quality of studies (mCMS: 68.7+-11 points in G1, 63.4+-14.3 points in G2;p=0.2) was similar in G1 and G2 Conclusion: Lateral soft tissue release during percutaneous HV surgery does not seem to improve the clinical and radiological outcome nor reduces the risk of recurrence of the deformity at a mean 4-year follow-up.