bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identifying The Prognostic Significance of Mitochondrial AAA Proteases YME1L1 Expression in Ovarian Cancer
Authors: Liao Wan-Ting , Chu Pei-Yi , Su Cheng-Chiung , Huang Mei-Shu , Tsui Wan-Lin , Chiu Ya-Ting , Wu Chun-Chi , Li Chia-Jung 
Published: January 2022

Abstract
Background:The discovery of early diagnosis and prognostic markers for ovarian cancer can significantly improve survival and reduce mortality. The role of the YME1L1 signaling axis in genetic alterations and immune infiltration of the tumor microenvironment remains unclear. Methods: Bioinformatics web resources, including GEPIA2, cBioPortal, Oncomine, Kaplan–Meier Plotter and TIMER were used to analyze the expression profile, prognostic value and immune infiltration of YME1L1.We further performed tissue microarray analysis of paraffin-embedded tissues from 60 ovarian cancer patients recorded at FIGO/TNM cancer staging. Results: Here, we use multi-omics analysis of multiple histological data to map the role of epigenetic and genetic alterations of YME1L1 in tumor immune infiltration and prognosis of cancer patients. We explored YME1L1 gene expression profiles by systematically analyzing the association of YME1L1 expression with the prognosis of ovarian cancer patients confirmed in multiple databases. High YME1L1 expression was associated with poorer overall survival and disease-free survival associated. Together, our studies suggest that YME1L1 may modulate tumor survival, immune features and contribute to tumor immune invasion, poor prognosis, and immunotherapy failure. Conclusion:Our findings may have clinical implications for the design of treatment strategies, prognosis assessment and follow-up management of patients receiving immunotherapy in a variety of cancers.
Synergetic Modulation of Plant Cadmium Tolerance via MYB75-mediated ROS Homeostasis and Transcriptional Regulation
Authors: Zheng Ting , Yang Feng , Zhang Dawei 
Published: January 2022

Abstract
Cadmium (Cd) is a heavy metal with biological toxicity, which can be detoxified through chelation and compartmentation in plants. Transcriptional regulation mediates plant Cd tolerance by modulating these processes. However, the mechanism remains to be studied. Our results showed that a previously unknown function of MYB75 transcription factor in the regulation of Cd tolerance. Cd exposure stimulates anthocyanin accumulation by raising MYB75 expression. Enhanced Cd tolerance was observed in the MYB75-overexpressing plants, whereas increased Cd sensitivity was found in the MYB75 loss-of-function mutants. Under Cd stress conditions, lower reactive oxygen species (ROS) levels were detected in MYB75-overexpressing plants than in wild type plants. In contrast, higher ROS levels were found in MYB75 loss-of-function mutants. Overexpression of MYB75 were associated with increased glutathione (GSH) and phytochelatin (PC) content by anthocyanin-mediated ROS homeostasis. Furthermore, the expression of Cd stress-related gene including ACBP2 and ABCC2 was elevated in MYB75-overexpressing plants, and this upregulation was mediated through the mechanism by which MYB75 directly bind to the promoter of ACBP2 and ABCC2. Our findings reveal an important role for MYB75 in regulation of plant Cd tolerance via anthocyanin-mediated ROS homeostasis and PC content, and through upregulation of Cd stress-related gene at transcriptional level.
Fine mapping of the tiller inhibition gene TIN5 in Triticum urartu
Authors: Si Yaoqi , Lu Qiao , Tian Shuiquan , Niu Jianqing , Cui Man , Liu Xiaolin , Gao Qiang , Shi Xiaoli , Ling Hong-Qing , Zheng Shusong 
Published: January 2022

Abstract
Grain yield in wheat (Triticum aestivum L.) is a polygenic trait representing many developmental processes and their interactions with environment. Among them, tillering capacity is an important agronomic trait for plant architecture and grain yield, but the genetic basis of tiller formation in wheat remains largely unknown. In this study, we identified a tiller inhibition mutant (tin5) from ethyl methane sulfonate (EMS) treated G1812 (Triticum urartu Thumanjan ex Gandilyan). A mapping population was constructed with tin5/G3146. Based on the sequence differences between G1812 and G3146, large InDels (≧5 bp) were selected and verified, and a skeleton physical map was constructed with genome-wide 168 polymorphic InDel markers. Genetic analysis revealed that the low-tiller phenotype was controlled by a single recessive locus, which we named TIN5. This locus was mapped to a 2.1-Mb region that contained 24 annotated genes in chromosome Tu7. Among these annotated genes, 16 genes expressed at the seedling stage, but only TuG1812G0700004539 showed a non-synonymous polymorphism between tin5 and WT. Our finding will facilitate its map-based cloning and pave the way for an in-depth analysis of the underlying genetic basis of tillering formation and regulation patterns.
Time-restricted feeding increases fat oxidation rate but not affect postprandial lipemia: a crossover trial
Authors: Chiu Chih-Hui , Chen Che-Hsiu , Wu Min-Huan , Hsieh Yu-Chen , Lin Zong-Yan , Chen Bo-Wei 
Published: January 2022

Abstract
Background: Studies have revealed that time-restricted feeding affects the fat oxidation rate; however, its effects on the fat oxidation rate and hyperlipidemia following high-fat meals are unclear. This study investigated the effects of 5-day time-restricted feeding on the fat oxidation rate and postprandial lipemia following high fat meals. Methods: In this random crossover experimental study, eight healthy male adults were included each in the 5-day time-restricted feeding trial and the control trial. The meals of the time-restricted feeding trial were provided at 12:00, 16:00, and 20:00. The meals of the control trial were provided at 08:00, 14:00, and 20:00. The contents of the meals of both trials were the same, and the calories of the meals met the 24-hour energy requirement of the participants. After 5 days of the intervention, the participants consumed high-fat meals on the sixth day, and their physiological changes were determined. Results: The fasting fat oxidation rate (p<0.001) and postprandial fat oxidation rate (p=0.019) of the time-restricted feeding trial were significantly higher than those of the control trial. The 24-hour energy consumption and postprandial triglyceride, blood glucose, insulin, glycerol, and free fatty acid concentrations of the two trials showed no significant differences (p>0.05). Conclusion: The results revealed that 5 days of time-restricted feeding effectively increased the fasting and postprandial fat oxidation rate, but it did not affect postprandial lipemia.
Titanium Dioxide Nano-Particles Recovered From Red Sediment Placer Low Graded Ilmenite With Microwave Heating Followed by Sds Solution
Authors: SRIK SATYA , Rao Raghupatruni 
Published: January 2022

Abstract
Microwave is source of environmentally heating of minerals. The present paper deals about the recovery of titania in form of slag with microwave reduction of oxidized ilmenite. This paper was further investigated for the recovery of upgraded titania from microwave heat treatment of titania obtained from ilmenite. The results show upgraded titania contain a very high graded TiO2 components with less amounts of alkaline-earth materials and other impurities as compared to titanium obtained from ilmenite. The upgraded titania was produced the crack and development of pores in the sample surface. An attempt was also made to prepare nano-titania material with suitable leaching and microwave heating. The results with TEM analysis and XRD analysis show the formation of nano titanium dioxide particles. The titanium dioxide nano materials can widely be used in pharmacy and medical industries, paints and coatings industries,, catalysts, semiconductors, optoelectronics industries and others including water filters areas.
Evaluation of the First Year(s) of Physicians Collaboration on an Interdisciplinary Electronic Consultation Platform in the Netherlands: Mixed Methods Observational Study
Authors: Sanavro Sanne M , van der Worp Henk , Jansen Danielle , Koning Paul , Blanker Marco H ,   Prisma Platform Study Group
Published: January 2022

Background
Complexity of health problems and aging of the population create an ongoing burden on the health care system with the general practitioner (GP) being the gatekeeper in primary care. In GPs daily practice, collaboration with specialists and exchange of knowledge from the secondary care play a crucial role in this system. Communication between primary and secondary care has shortcomings for health care workers that want to practice sustainable patient-centered health care. Therefore, a new digital interactive platform was developed: Prisma.

Objective
This study aims to describe the development of a digital consultation platform (Prisma) to connect GPs with hospital specialists via the Siilo application and to evaluate the first year of use, including consultations, topic diversity, and number of participating physicians.

Methods
We conducted a mixed methods observational study, analyzing qualitative and quantitative data for cases posted on the platform between June 2018 and May 2020. Any GP can post questions to an interdisciplinary group of secondary care specialists, with the platform designed to facilitate discussion and knowledge exchange for all users.

Results
In total, 3674 cases were posted by 424 GPs across 16 specialisms. Most questions and answers concerned diagnosis, nonmedical treatment, and medication. Mean response time was 76 minutes (range 44-252). An average of 3 users engaged with each case (up to 7 specialists). Almost half of the internal medicine cases received responses from at least two specialisms in secondary care, contrasting with about one-fifth for dermatology. Of note, the growth in consultations was steepest for dermatology.

Conclusions
Digital consultations offer the possibility for GPs to receive quick responses when seeking advice. The interdisciplinary approach of Prisma creates opportunities for digital patient-centered networking.
Bima-Drona dalam Lakon Dewa Ruci sebagai Vayu-Vata, Transformasi Prana dalam Pertunjukan Wayang
Authors: Wahyudi Aris 
Published: January 2022

AbstrackRelationship of Bima and Drona in Dewa Ruci story is unique. Eventhough Drona puts Bima into danger, Bima chooses Drona as a teacher. It is because Bima has not obtained a very good spiritual knowledge about life yet since a hero is supposed to have high spiritual qualities and good prayers. The wayang tradition describes Bima as a cruel hero who is not religious, and Drona does not have good brahman qualifications, either. This leads to an assumption that their relationship must be important and meaningful. The question is what does the relationship between Bima-Drona mean, namely Bima as the learner who becomes the recipient of spiritual knowledge of welfare and Drona as his teacher? With structural mythological analysis, it can be concluded that the relationshp between Bima-Drona is an identification of Vãyu-Vãta as the transformation of prana in the Syiwapuja rituals. AbstrakBima dan Drona dalam cerita Dewa Ruci adalah hubungan yang unik. Meski Drona menjerumuskan Bima, namun Bima memilih Drona sebagai guru. Apalagi hal yang berhubungan dengan pengetahuan spiritual yang sangat baik tentang kehidupan, di mana dapat ditemukan oleh pahlawan yang memiliki kualitas spiritual yang tinggi, doa yang baik, tetapi Bima belum. Tradisi wayang memaparkan bahwa Bima adalah pahlawan yang kejam, tidak berkarakter religius dan Drona belum memiliki kualifikasi brahmana yang baik. Fenomena itu memunculkan asumsi bahwa hubungan tersebut pasti bermakna. Pertanyaannya adalah apa arti Bima-Drona, yaitu Bima sebagai penerima pengetahuan spiritual tentang kesejahteraan dan Drona sebagai gurunya? Dengan analisis mitologi struktural dapat disimpulkan bahwa Bima-Drona adalah identifikasi Vãyu-Vãta sebagai transformasi prãna dalam upacara ritual Syiwapuja.
The tax on certain financial institutions in Poland – objectives and implications
Authors: Twarowska-Ratajczak Małgorzata , Twarowska-Mól Katarzyna 
Published: January 2022

Background: The introduction of the tax on certain financial institutions in Poland was accompanied by many emotions about the fact that it is a tax that had not previously been applicable in Poland, and that it also concerned financial institutions that became the subject of particular interest in the era of intensified discussion on the reform and sealing of the tax system. On 1 February 2016, the Act on Tax on Certain Financial Institutions became effective. The law introduced a wealth tax, in which assets of certain financial institutions are subject to taxation.
Research purpose: The paper assesses the impact of the introduction of a tax on certain financial institutions in Poland, in particular, the impact of the tax on the financial stability of the banking sector, loans to NFCs and households, and ownership structure. It also examines the scale of tax shifting to bank customers.1
Methods: The paper presents an overview of the literature on the subject, the construction of the bank tax, and the most important effects of taxation on the banking sector, bank customers, and the whole economy. The desk research method was used, which involved compiling, analyzing, and processing data and information from existing sources, and on that basis, formulating conclusions.
Conclusions: Banks passed on the costs of the bank tax to their customers in the form of higher fees and commissions, as well as higher interest rates on loans and lower interest rates on deposits. Bank profitability increased after the introduction of the bank tax, so it can be concluded that the banks and their owners have not borne the burden of the tax.
Polityka wynagradzania liderów akademickich w reformowanym systemie szkolnictwa wyższego
Authors: Urbanek Piotr 
Published: January 2022

Przedmiot badań: Reformy systemów szkolnictwa wyższego inspirowane ideami no­wego zarządzania publicznego wprowadzają menedżerską logikę zarządzania uczelnia­mi. Silne przywództwo liderów akademickich, hierarchiczne struktury władzy uczelni, a także nacisk na efektywność i rozliczalność są ważnymi elementami reform. Jednym z istotnych rozwiązań stosowanych w ramach tej logiki powinna być polityka wynagra­dzania liderów akademickich oparta na biznesowej zasadzie „płacy za wyniki”. W arty­kule przedstawiono rozwiązania legislacyjne wprowadzone w znowelizowanej Ustawie prawo o szkolnictwie wyższym i nauce oraz przeprowadzono analizę wysokości i struk­tury wynagrodzeń rektorów 34 uczelni publicznych.
Cel badawczy: Celem artykułu jest ocena polityki wynagradzania rektorów polskich uczelni publicznych. 1
Metoda badawcza: Metodami badawczymi użytymi w artykule są krytyczna analiza piśmiennictwa oraz badanie dokumentów źródłowych.
Wyniki: Otrzymane wyniki pokazują, że gorset legislacyjny nałożony przez Ustawę 2.0 nie pozostawia radom uczelni zbyt dużej swobody, jeśli chodzi o różnicowanie wy­sokości wynagrodzenia ogółem, jak i poszczególnych jego komponentów. W szcze­gólności rady nie wykorzystują w praktyce ustawowego zapisu pozwalającego na po­wiązanie wynagrodzenia ze stopniem złożoności zadań realizowanych przez rektora. Niska transparentność procedur ustalania wynagrodzeń uniemożliwia dokonanie oceny efektywności polityki wynagradzania oraz roli, jaką pełni ona w instytucjonalnej stra­tegii uczelni.
Fuzzy Soc-Semi-Prime Sub-Modules
Authors: Merie Saad S. , Khalf Hatam Yahya 
Published: January 2022

In this paper, we study a new concept of fuzzy sub-module, called fuzzy socle semi-prime sub-module that is a generalization the concept of semi-prime fuzzy sub-module and fuzzy of approximately semi-prime sub-module in the ordinary sense. This leads us to introduce level property which studies the relation between the ordinary and fuzzy sense of approximately semi-prime sub-module. Also, some of its characteristics and notions such as the intersection, image and external direct sum of fuzzy socle semi-prime sub-modules are introduced. Furthermore, the relation between the fuzzy socle semi-prime sub-module and other types of fuzzy sub-module presented.
Peculiarities of current melatonin application — successful experience and new opportunities
Authors: Svyrydova N. K. , Belkina I. O. , Karpenko N. O. 
Published: January 2022

The paper presents current information about the physiological functions and pharmacological properties of hormone melatonin. Consideration was given to the results of clinical trials, confirming melatonin efficacy in the treatment of insomnia of various etiology in patients of different age groups in comparison of other hypnotics, both as monotherapy and combined therapy of arterial hypertension with the purpose of regulation of circadian rhythms in case of desynchronosis (jet lug, shift work, syndromes sleep phase disturbances). An experience of exogenous melatonin application at coronavirus disease (COVID‑19) has been analyzed. The review is based on search results in the PubMed, Medline, Scopus databases for the period 1997–2021 for the keywords melatonin, therapeutic use, insomnia, hypertension, circadian rhythm disturbances, COVID‑19.
Data showed that melatonin was an effective and safe medication that can be recommended in all cases of sleep disturbances and for patients of any age with or without concomitant pathology. It is well tolerated and goes well with other drugs. Melatonin efficacy and safety was registered at its simultaneous use with antihypertensive, hypoglycemic and anti‑inflammatory drugs in elderly and middle‑aged people with arterial hypertension. Owing to its anti‑inflammatory, immunoregulatory, antioxidant effects, melatonin diminishes the risk of infections, inflammation, and oxidative stress in case of disease development, it promotes health in people at risk, has a neuroprotective effect in patients with COVID‑19, can serve as an adjuvant to boost anti‑SARS‑CoV‑2 vaccines. As an antioxidant and anti‑inflammatory agent, melatonin counteracts acute lung injury/acute respiratory distress syndrome caused by viral and bacterial infections.
Melatonin preparation Melafresh (Prime Health Ltd., Canada) proved to be an effective addition to the therapy of sleep disorders of various etiology, especially in cases of their onset due to inconsistent circadian rhythms, it prevents or attenuates desynchronosis of circadian rhythms, violation of daily sleep/wakefulness cycles, decreases the number of episodes of awakening at night, restores full sleep after psycho‑emotional overload and stress, and promotes easy awakening. One of Melafresh advantages is its drug form (sublingual tablets) as it increases its bioavailability and concentration in blood.
Sistem Prediksi Kondisi Kelahiran Bayi menggunakan Klasifikasi Naïve Bayes
Authors: Damar Rani Handini Arga , Zuhri Syaifuddin 
Published: January 2022

Dalam bidang kesehatan, data mining dapat dimanfaatkan untuk memprediksi suatu penyakit dari data rekam medis pasien. Dengan metode research and development klasifikasi pada data mining, data seperti umur, tekanan darah, berat badan, letak janin, tinggi fundus uterus dan atribut lainnya, dapat digunakan untuk memprediksi kemungkinan pasien terkena suatu penyakit. Oleh karena itu, peneliti membuat sistem prediksi kondisi kelahiran bayi mengunakan metode klasifikasi naïve bayes yang berfungsi untuk memprediksi kelahiran bayi. Teknik data mining yang diterapkan pada aplikasi yang dibangun adalah metode klasifikasi naïve bayes. Dengan menggunakan pengembangan sistem berbasis web yaitu akuisisi pengetahuan. Hasil dari penelitian ini adalah aplikasi untuk memprediksi seseorang akan melahirkan secara normal atau beresiko(cesar) berdasarkan hasil pemeriksaan dokter. Dari hasil prediksi tersebut dapat digunakan untuk menentukan hasil rata-rata kelahiran bayi setiap bulan. Data yang kami gunakan ada total 165 data ibu hamil diantaranya kami bagi 2 yaitu 110 data training dan 55 data testing/data uji, model prediksi dievaluasi menggunakan x cross validation dalam proses evaluasi dan perhitungan nilai akurasi, precission, dan recall. Dengan nilai akurasi 92,73% dan precission 83,33% serta recall 100%.
Risk management in the sphere of wages
Authors: Koval Svitlana 
Published: January 2022

The subject of article is to study the problems of risk management associated, in particular, with the discrepancies of official and actual wage assessments. The most important value for effective risk management has adequate information support, which includes a wide range of various types of information: statistical, economic, commercial, financial, legal, technical, etc. In the study, general scientific and special methods were used: analysis and synthesis, analogy and comparison, statistical estimates, etc. The results of work. The peculiarities of some methods of comparing official and actual wage assessments based on the principles of audit inspections are highlighted. The results of the study can be used by all stakeholders, including the authorities of the state executive power in improving the mechanisms for implementing the socio-economic policy of employment and state regulation of the labor market in the field of remuneration. The conclusions. 1. Based on the methods of comparing official and actual wage assessments in accordance with established criteria, a conditional-positive conclusion is provided to the reliability and legality of information reflected in the financial statements, according to the results of operations on the process of remuneration in 2020. 2. The main tasks that should be aimed at solving risk management issues by auditing calculations for remuneration are defined: confirmation of the reliability of accruals and payments to employees, displaying processes of accounting processes; finding out the legality and completeness of salaries and other payments to employees in favor of the enterprise, other subjects; verification in the organization of analytical accounting calculations for remuneration and interconnection of analytical and synthetic accounting; the assessment of the administration takes place in order to timely collect debt payments to employees, which is an important source of information to verify these issues. 3. The promising areas of research in the field of labor accounting and its payment in order to minimize risks include: control over compliance with regular discipline and rational use of working time; the correct calculation of labor costs in the account of labor; legitimate payroll and dependents from it; implementation of timely and reliable salary calculations; control over the use of the wage fund; providing consumers with information on labor and wages.