bluuebunny/crossref_metadata_2025_split huggingface dataset:
Male aggressiveness during the female fertile phase in relation to extra-pair paternity, plumage ornaments and female traits
Authors: Beccardi Matteo , Plaza Mireia , Moreno Juan , Cantarero Alejandro 
Published: November 2022

AbstractIn many bird species, physical aggression between males become more frequent during the female’s fertile period, as female encounters with extra-pair males are more frequent and can entail paternity losses. Male aggressiveness during this stage has been proposed as crucial for ensuring male reproductive success. Thus, plumage ornaments could represent honest signals of individual quality that could reflect the aggressiveness of paired territorial males. Furthermore, male aggressiveness could be related to mate quality or defensive capacity. We quantified extra-pair paternity in the broods and investigated the association of male and female traits with the aggressive behaviour of territorial paired males in a Spanish population of Pied Flycatchers (Ficedula hypoleuca), where territorial intrusions were simulated during the female fertile period by placing a taxidermic male mount close to the nest. We predicted that (1) more aggressive males should better protect their mates from intruding males and thereby reduce their paternity losses, (2) males with larger white patches and higher UV reflectance of wing patches should respond more strongly to intrusions, and (3) that males should be more aggressive when mated with higher quality females. We found evidence that males that responded less intensely to a territorial intrusion suffered a higher paternity loss, which offers strong support to the basic tenet of the theory of territoriality as paternity defence. Moreover, both the level of male aggressiveness and control of the territory increased with male UV reflectance of wing patches. Finally, we found, contrary to our prediction, that males were less aggressive when mated with more ornamented females.
Rectangular eigenvalue problems
Authors: Hashemi Behnam , Nakatsukasa Yuji , Trefethen Lloyd N. 
Published: November 2022

AbstractOften the easiest way to discretize an ordinary or partial differential equation is by a rectangular numerical method, in which n basis functions are sampled at m ≫ n collocation points. We show how eigenvalue problems can be solved in this setting by QR reduction to square matrix generalized eigenvalue problems. The method applies equally in the limit “$m=\infty $
m
=
∞
” of eigenvalue problems for quasimatrices. Numerical examples are presented as well as pointers to related literature.
A survey on physarum polycephalum intelligent foraging behaviour and bio-inspired applications
Authors: Awad Abubakr , Pang Wei , Lusseau David , Coghill George M. 
Published: November 2022

AbstractIn recent years, research on Physarum polycephalum has become more popular after Nakagaki (AIR 407: 6803-470, 2000) performed their famous experiment showing that Physarum was able to find the shortest route through a maze. Subsequent researches have confirmed the ability of Physarum-inspired algorithms to solve a wide range of real-world applications. In contrast to previous reviews that either focus on biological aspects or bio-inspired applications, here we present a comprehensive review that highlights recent Physarum polycephalum biological aspects, mathematical models, and Physarum bio-inspired algorithms and their applications. The novelty of this review stems from our exploration of Physarum intelligent behaviour in competition settings. Further, we have presented our new model to simulate Physarum in competition, where multiple Physarum interact with each other and with their environments. The bio-inspired Physarum in competition algorithms proved to have great potentials for future research.
Sustained release system of paclitaxel based on composite nanofibers for inhibiting renal clear cell carcinoma
Authors: Cai Zhiduan , Zhuang Haoquan , Li Xiezhao , Liang Siyang , Luo Wenjun , Yuan Yaoji , Xu Yuyu , Jin Lin , Xu Guibin 
Published: November 2022

AbstractThe recurrence and metastasis of renal cell carcinoma aresevere challenges in clinical treatment. At present, it is urgent to find a strategy to solve this problem and improve the therapeutic effect. In this study, we designed a programmed release system of anticancer drugs by preparing a nanofiber system with two kinds of diameters and biomaterials (polylactic acid-glycolic acid (PLGA) and silk protein) as drug carriers (paclitaxel), which inspired the occurrence and pathological microenvironment of renal cell carcinoma. The controlled degradation of PLGA nanofibers as a drug carrier achieved the short-term release of paclitaxel, which could rapidly inhibit the spread and metastasis of renal cancer, while the silk protein nanofibers as a drug carrier with slow degradation could provide the long time and continuous release of paclitaxel to prevent the proliferation of renal cancer cells and inhibit recurrence. The synergistic effect of the sustained release system of paclitaxel successfully achieved inhibition of the recurrence and metastasis of renal cell carcinoma and improve the therapeutic effect of renal cell carcinoma. The paclitaxel release profile showed that the PLGA nanofiber drug system provided controlled release of paclitaxel in the first 14 days, while the silk protein nanofiber system provided a relatively stable and long-duration release of paclitaxel (1 month). In vitro experiments showed that the sustained release system of paclitaxel had a lasting inhibitory effect on the proliferation of renal clear cell carcinoma cells. These results indicated that the sustained release system of paclitaxel could be used as a promising drug delivery system with highly efficient implementations to reduce the frequency of systemic administration and inhibit tumor growth and recurrence, which could provide a new strategy for the clinical applications in renal cell carcinoma microenvironment.
Science of the Van Allen Probes Science Operations Centers
Authors: Manweiler Jerry W. , Breneman Aaron , Niehof Jonathan , Larsen Brian , Romeo Giuseppe , Stephens Grant , Halford Alexa , Kletzing Craig , Brown Lawrence E. , Spence Harlan , Reeves Geoff , Friedel Reiner , Smith Sonya , Skoug Ruth , Blake Bern , Baker Dan , Kanekal Shri , Hoxie Vaughn , Jaynes Allison , Wygant John , Bonnell John , Crawford Danielle , Gkioulidou Matina , Lanzerotti Louis J. , Mitchell Donald G. , Gerrard Andrew , Ukhorskiy Aleksandr , Sotirelis Thomas , Barnes Robin J. , Millan Robyn , Harris Blaine 
Published: November 2022

AbstractThe Van Allen Probes mission operations materialized through a distributed model in which operational responsibility was divided between the Mission Operations Center (MOC) and separate instrument specific SOCs. The sole MOC handled all aspects of telemetering and receiving tasks as well as certain scientifically relevant ancillary tasks. Each instrument science team developed individual instrument specific SOCs proficient in unique capabilities in support of science data acquisition, data processing, instrument performance, and tools for the instrument team scientists. In parallel activities, project scientists took on the task of providing a significant modeling tool base usable by the instrument science teams and the larger scientific community. With a mission as complex as Van Allen Probes, scientific inquiry occurred due to constant and significant collaboration between the SOCs and in concert with the project science team. Planned cross-instrument coordinated observations resulted in critical discoveries during the seven-year mission. Instrument cross-calibration activities elucidated a more seamless set of data products. Specific topics include post-launch changes and enhancements to the SOCs, discussion of coordination activities between the SOCs, SOC specific analysis software, modeling software provided by the Van Allen Probes project, and a section on lessons learned. One of the most significant lessons learned was the importance of the original decision to implement individual team SOCs providing timely and well-documented instrument data for the NASA Van Allen Probes Mission scientists and the larger magnetospheric and radiation belt scientific community.
Scope of heuristics and digitalization: the case of marketing automation
Authors: Guercini Simone 
Published: November 2022

AbstractThis paper focuses on the impact of digitalization and marketing automation on the “scope” of the heuristics adopted in the marketers’ decision-making processes. The “scope” refers to the decision-making contexts in which the use of the heuristic rules is diffuse and is effective. More precisely, “scope" is (the extension of) the field in which a heuristic can be applied (successfully). The article is based on evidence collected through ethnographic interviews with twenty-three experienced marketers to discuss the impact of marketing automation on the scope of heuristic rules in decision-making. The marketers interviewed make extensive use of heuristics to manage their tasks as emerged from previous exploratory research. The paper discusses how the field of application of marketing experts' heuristics evolves as result of the digitalization and in particular of the use of automatic marketing systems. The adoption of the new automatic marketing tools modifies the task environment and the field of use of the traditional heuristic rules, but heuristics remain fundamental in the definition phase of the inputs for the automatic marketing systems, or for the interpretation of the output and therefore for the control of the marketing automation. The paper clarifies the concept of scope of heuristics and offers a rich description of the impact of marketing automation on scope.
Biochemical responses, feeding and survival in the solitary bee Osmia bicornis following exposure to an insecticide and a fungicide alone and in combination
Authors: Martins Cátia Ariana Henriques , Caliani Ilaria , D’Agostino Antonella , Di Noi Agata , Casini Silvia , Parrilli Martina , Azpiazu Celeste , Bosch Jordi , Sgolastra Fabio 
Published: November 2022

Abstract
In agricultural ecosystems, bees are exposed to combinations of pesticides that may have been applied at different times. For example, bees visiting a flowering crop may be chronically exposed to low concentrations of systemic insecticides applied before bloom and then to a pulse of fungicide, considered safe for bees, applied during bloom. In this study, we simulate this scenario under laboratory conditions with females of the solitary bee, Osmia bicornis L. We studied the effects of chronic exposure to the neonicotinoid insecticide, Confidor® (imidacloprid) at a realistic concentration, and of a pulse (1 day) exposure of the fungicide Folicur® SE (tebuconazole) at field application rate. Syrup consumption, survival, and four biomarkers: acetylcholinesterase (AChE), carboxylesterase (CaE), glutathione S-transferase (GST), and alkaline phosphatase (ALP) were evaluated at two different time points. An integrated biological response (IBRv2) index was elaborated with the biomarker results. The fungicide pulse had no impact on survival but temporarily reduced syrup consumption and increased the IBRv2 index, indicating potential molecular alterations. The neonicotinoid significantly reduced syrup consumption, survival, and the neurological activity of the enzymes. The co-exposure neonicotinoid-fungicide did not increase toxicity at the tested concentrations. AChE proved to be an efficient biomarker for the detection of early effects for both the insecticide and the fungicide. Our results highlight the importance of assessing individual and sub-individual endpoints to better understand pesticide effects on bees.
The Diabetes Health Plan and Healthcare Utilization Among Beneficiaries with Low Incomes
Authors: Narain Kimberly Danae Cauley , Turk Norman , Duru O. Kenrik , Moin Tannaz , Mangione Carol M. 
Published: November 2022

Abstract
Background
The socioeconomic status (SES) gradient in hospital and emergency room utilization among adults with type 2 diabetes (T2DM) is partially driven by cost-related non-adherence.

Objective
To test the impact of the Diabetes Health Plan (DHP), a diabetes-specific health plan incorporating value-based insurance design principles on healthcare utilization among low-income adults with T2DM.

Design
To examine the impact of the DHP on healthcare utilization, we employed a difference-in-differences (DID) study design with a propensity-matched comparison group. We modeled count and dichotomous outcomes using Poisson and logit models, respectively.

Participants
Cohort of adults (18–64) with T2DM, with an annual household income <$ 30,000, and who were continuously enrolled in an employer-sponsored UnitedHealthcare plan for at least 2 years between 2009 and 2014.

Interventions
The DHP reduces or eliminates out-of-pocket costs for disease management visits, diabetes-related medicines, and diabetes self-monitoring supplies. The DHP also provides access to diabetes-specific telephone case management as well as other online resources.

Main Measures
Number of disease management visits (N = 1732), any emergency room utilization (N = 1758), and any hospitalization (N = 1733), within the year.

Key Results
DID models predicting disease management visits suggested that DHP-exposed beneficiaries had 1.7 fewer in-person disease management visits per year (− 1.70 [95% CI: − 2.19, − 1.20], p < 0.001), on average, than comparison beneficiaries. Models for emergency room (0.00 [95% CI: − 0.06, 0.06], p = 0.966) and hospital utilization (− 0.03 [95% CI: − 0.08, − 0.01], p = 0.164) did not demonstrate statistically significant changes associated with DHP exposure.

Conclusions
While no relationship between DHP exposure and high-cost utilization was observed in the short term, fewer in-person disease management visits were observed. Future studies are needed to determine the clinical implications of these findings.
Capillary penetration for the development of a method for the assessment of shelf-life of foods
Authors: Georgiou D. , Kalogianni E. P. , Dimitreli G. , Ftouli E. , Parisi S. 
Published: November 2022

AbstractTemperature sensitive foods require monitoring of their time–temperature history in order to assure their safety and high quality. The same holds for other perishable products such as medical and pharmaceutical. The best means to have information on the time–temperature history of a product is by having measurement of these variables along the whole product shelf-life. As an answer to this need several time–temperature indicators have been developed and commercialized for monitoring the quality of food products. In this work a full history time–temperature indicator (TTI) has been designed and developed based on capillary penetration of safe and low surface tension liquids in micro porous polyethylene porous media. For the development of the indicator the appropriate porous media and penetration liquids were selected and capillary penetration of the selected liquids took place at two different temperatures. Based on the results of the capillary penetration experiments the TTI was developed and a prototype was evaluated in a food product in order to assess its capability to be used in food packaging. The results showed that the TTI is simple in use and could provide a quantitative and easy-to-read response. Moreover, the response of the TTI could be calibrated by changing several design parameters, in order to match the quality deterioration kinetics of the specific food product to be monitored.
Understanding the interplay between targeted motivation interventions and motivational teaching practices in mathematics classrooms
Authors: Gaspard Hanna , Parrisius Cora , Nagengast Benjamin , Trautwein Ulrich 
Published: November 2022

AbstractPrior research has shown that brief motivation interventions, such as interventions targeting students’ perceptions concerning relevance of the learning material, can have long-lasting effects on students’ motivation and performance. However, the educational contexts in which these interventions have been implemented have their own motivational affordances, such as the extent to which teachers support students’ perceptions of relevance in regular classes. According to the seed-and-soil hypothesis for the effectiveness of psychological interventions, such interventions can be seen like a “seed” that needs to be implemented in a supportive educational context (i.e., the “soil”) in order to work. Therefore, in this study we examined the interplay between a one-time relevance intervention implemented in mathematics classrooms and the mathematics teacher’s relevance support as perceived by the students before and after the intervention. Data stemmed from a cluster-randomized controlled trial with 79 ninth-grade mathematics classes (N = 1744 students) in which the intervention was implemented by the mathematics teacher or a master’s student, both trained for this purpose. Multilevel moderation models showed that both intervention conditions had larger effects when students perceived higher relevance support before or after the intervention, thus providing support for the seed-and-soil hypothesis. Furthermore, multilevel mediation models indicated a positive effect of the teacher condition on perceived relevance support at posttest compared with the control condition, which partly explained the positive effect of this intervention condition on utility value at follow-up. The results shed light on the contexts in which these interventions are most effective and the mechanisms through which they work.
PCSK9 Inhibition and Risk of Diabetes: Should We Worry?
Authors: Carugo Stefano , Sirtori Cesare R. , Corsini Alberto , Tokgozoglu Lale , Ruscica Massimiliano 
Published: November 2022

Abstract
Purpose of Review
Since the clinical benefit of proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors occurs in a setting of reducing low-density lipoprotein-cholesterol (LDL-C) to unprecedentedly low levels, it becomes of interest to investigate possible adverse effects pertaining to the risk of new-onset diabetes (NOD).

Recent Findings
While safety results reported in either meta-analyses or cardiovascular outcome trials FOURIER (with evolocumab) and ODYSSEY (with alirocumab) did not rise the incidence of NOD, Mendelian randomization analyses were almost concordant in showing an increased risk of NOD. This evidence was in line with post-marketing safety reports highlighting that evolocumab and alirocumab were primarily related to mild hyperglycaemia rather than diabetes, with most of the hyperglycaemic events occurring during the first 6 months of treatment.

Summary
Considering the different nature of genetic studies and of randomized controlled trials, with careful monitoring of patients, particularly in the earlier phases of treatment, and the identification of those more susceptible to develop NOD, treatment with PCSK9 inhibitors should be of minimal concern.
Comparison and Investigation of Exosomes from Human Amniotic Fluid Stem Cells and Human Breast Milk in Alleviating Neonatal Necrotizing Enterocolitis
Authors: Hu Xiaohan , Zhang Rui , Liang Hansi , An Jingnan , Yang Yuan , Huo Jie , Chen Zhenjiang , Quan Wei , Jiang Lu , Li Cancan , Li Jian , Li Fang , Xu Yunyun , Zhu Xueping 
Published: November 2022

Abstract
In view of the devastating impact of neonatal necrotizing enterocolitis (NEC) on newborns, the research on its intervention is particularly important. Although exosomes from human amniotic fluid stem cells (AFSC) and human breast milk (HBM) can protect against NEC, their mechanisms remain unclear. Here, we intend to compare the intervention effects of two types of exosomes on NEC mouse model and reveal their respective regulatory mechanisms. In general, both AFSC-derived exosomes (AFSC-exos) and HBM-derived exosomes (HBM- exos) can alleviate NEC- associated intestinal injury, significantly reduce NEC score, and reduce systemic and ileal inflammation and NEC related brain injury during experimental NEC. However, the mode and mechanism of action of the two sources of exosomes were not identical. In vivo, the number of ileal crypts was more significantly restored after HBM-exos intervention than AFSC-exos, and in vitro, HBM-exos preferentially inhibited the inflammatory response of intestinal epithelial cells (IECs), whereas AFSC-exos preferentially regulated the migration of IECs. Mechanistically, GO and KEGG analyses revealed the different therapeutic mechanisms of AFSC-exos and HBM-exos in NEC. Taken together, our results illustrate that AFSC-exos and HBM-exos reduce the severity of experimental NEC and intestinal damage through different mechanisms, supporting the potential of cell-free or breast milk free exosome therapy for NEC.

Graphical Abstract
Innovation Despite Backsliding—the Importance of the Events of 7th August 2020 for Polish LGBTQIA Youth
Authors: Sobczak Michał 
Published: November 2022

AbstractIn this paper, I analysed the events of 7th August 2020 in Warsaw, when 48 people were detained by the Polish police who brutally raided solidarity demonstration with non-binary activist Margot Szutowicz. The aim of the paper is to explore queer activism in Poland on microsociological level using Gabriel Tarde imitation theory. I tried to show how individual experience of resistance gave rise to new, innovative forms of activism which became a social phenomenon. In my research, I used in-depth interviews with some of detainees and over 180 diaries/memoirs of Polish LGBTQIA people.
On the initial-boundary value problem for a non-local elliptic-hyperbolic system related to the short pulse equation
Authors: Coclite Giuseppe Maria , di Ruvo Lorenzo 
Published: November 2022

AbstractIn this paper, we prove the well-posedness of the initial-boundary value problem for a non-local elliptic-hyperbolic system related to the short pulse equation. Our arguments are based on energy estimates and passing to the limit in a vanishing viscosity approximation of the problem.
National landscape assessment of academic medical center support for expanded access to investigational products
Authors: Gravelin Misty , Adamo Joan E. , Ellison Sharon , Segear Erika , Parrish Amanda B. , Deeter Christine , Hamill Jennifer , Rigan Laurie , Mashour George A. , Weatherwax Kevin J. 
Published: November 2022

Abstract
Expanded access (EA) provides a pathway for the clinical use of investigational products (drugs, biologics, and medical devices) for patients who are without satisfactory therapeutic options and for whom a clinical trial is not available. Academic medical centers (AMCs) are likely to encounter EA requests, but it is unknown what support is available at these institutions for physicians seeking EA for patients. Methods: A landscape assessment was conducted at AMCs, focused on those within the Clinical and Translational Science Awards (CTSA) consortium. Results: Forty-seven responses were evaluated including 42 CTSA hubs. The large majority (43 of 47 respondents) reported using single-patient EA, while 37 reported multi-patient industry sponsored EA and 37 reported multi-patient investigator-initiated EA. Only half reported central tracking of EA requests. Support was available at 89% of sites for single-patient EA but less often for multi-patient EA. Types of support varied and were focused largely on the initial submission to the FDA. Conclusion: Use of and support for EA is widespread at AMCs, with support focused on single-patient requests. Gaps in support are common for activities after initial submission, such as FDA reporting and data collection.