bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pengkajian Terapi COVID-19 Pada Pasien Rawat Inap Komorbid Hipertensi Terhadap Derajat Keparahan Penyakit di RSJPD Harapan Kita
Authors: Kurniawan Adin Hakim , Puspita Nanda , Meitinawati Tri Indriyani , Lestiani Lestiani 
Published: July 2022

<p>Kematian akibat Covid-19 menurut <em>Centers for Disease Control and Prevention</em> di Amerika Serikat terjadi pada pasien rentan dan memiliki riwayat komorbid penyakit seperti hipertensi. Virus SARS Cov-19 masuk kedalam sel manusia dan menginfeksi melalui ikatan dengan reseptor <em>Angitensin Converting Enzym 2</em> (ACE 2). Terapi farmakologi pada penanganan Covid-19 dengan riwayat komorbid hipertensi dalam tahap pengujian secara klinis masih perlu dilakukan monitoring pengobatan yang tepat dan rasional sehingga perlu pengkajian farmakoterapi berdasarkan derajat keparahan penyakit. Penelitian ini bertujuan memahami faktor yang mempengaruhi derajat keparahan penyakit dan karakteristik terapi Covid-19 pada pasien rawat inap komorbid hipertensi. Penelitian ini menggunakan desain penelitian <em>cohort retrospective</em><em>. </em>Pengambilan data di RSJPD Harapan menggunakan rekam medis pasien rawat inap dengan pasien Covid-19 pada komorbid hipertensi pada periode November 2020 sampai April 2021. Teknik pengambilan sampel menggunakan <em>consequtive sampling</em> dan Analisis statistik <em>Chi square</em>. Hasil penelitian menunjukan,dari 80 pasien, subjek penelitian laki-laki sebanyak 45 pasien (56,31%), usia produktif 45 pasien (56,30%). Kesesuaian peresepan dosis dan frekuensi terapi Covid-19sebesar 99,03%. Hasil analisis bivariat menunjukan adanya perbedaan bermakna pada pemberian terapi suportif Covid-19 (p=0,034), saturasi oksigen (p=0,024) serta lama perawatan pasien (p=0,008) terhadap derajat keparahan penyakit. Adapun hasil terapi Covid-19 memiliki perbedaan bermakna terhadap derajat keparahan, terdapat pada terapi levofloxacin (p=0,034);osetalmivir (p=0,030); favipiravir (p=0,027); remdesivir (p=0,009) dan spironolakton (p=0,034).</p>
Pemberdayaan Kader Kesehatan untuk Mendukung Program Indonesia Sehat melalui Pendekatan Keluarga (PISPK) dan Tatalaksana Diabetes Mellitus (DM), Hipertensi dan Merokok
Authors: Sari Yulia , Haryati Sri , Setyawan Sigit , Prasita Negara Khesara Sastrin , Dirgahayu Paramasari , Wijayanti Lilik , Ma’rufah Siti , Listyaningsih S Endang , Riyadi Slamet , Supriyana Dwi Surya , Purnomo Sugeng 
Published: July 2022

<p><strong>Pendahuluan:</strong> Program Indonesia Sehat dengan Pendekatan Keluarga (PISPK) adalah suatu program yang mempunyai sasaran meningkatnya derajat kesehatan dan status gizi masyarakat melalui upaya kesehatan dan pemberdayaan masyarakat yang didukung dengan perlindungan finansial dan pemerataan pelayanan kesehatan. Program Indonesia Sehat dilaksanakan dengan menegakkan penerapan paradigma sehat. Penerapan paradigma sehat dilakukan dengan strategi pengarusutamaan kesehatan dalam pembangunan, penguatan upaya promotif dan preventif, serta pemberdayaan masyarakat<sup>1</sup>. Tenaga medis dan kader kesehatan adalah pihak-pihak yang mempunyai peranan dalam pencapaian PISPK dan menurunkan angka kesakitan DM. Kader kesehatan sebagai sukarelawan dalam membantu pelayanan kesehatan bagi masyarakat. Kader perlu mendapat perhatian khusus untuk dapat membantu pencapaian indikator dalam PISPK dan penyakit DM. Pengabdian bertujuan memberikan penyuluhan dan pendampingan kepada kader Kesehatan. Materi berupa pengetahuan tentang diabetes melitus, hipertensi dan merokok.Untuk PISPK materi meliputi 12 indikator PISPK. Untuk DM meliputi makanan yang baik untuk penderita DM, kaki DM (diabetic food), komplikasi DM dan senam kaki untuk penderita DM.Selain kegiatan penyuluhan juga dilakukan demo terapi akupresur. Saat ini kebutuhan masyarakat akan terapi komplementer cukup tinggi. Kurang lebih 80% masyarakat Indonesia mencari pengobatan alternatif, ini karena dipengaruhi oleh beberapa faktor antara lain keyakinan, keuangan, reaksi obat kimia dan tingkat kesembuhan. Terapi komplementer merupakan terapi modalitas yang bersifat melengkapi terapi konvensional yang bertujuan untuk mendapatkan hasil pengobatan yang maksimal<sup>2</sup>.</p><p><strong>Metode:</strong> Pengabdian ini akan dilakukan dengan metode HIRARC yaitu <em>Hazard Identification, Risk Assessment, dan Risk Control</em>. Pengabdi memberikan intervensi berupa pendampingan kepada 30 kader masyarakat di wilayah Puskesmas Nguter Sukoharjo. Hasil dan pembahasan: Hasil posttest menunjukkan prosentase peningkatan pengetahuan diabetes melitus 12,2 %, hipertensi 6,33% dan merokok 2,33%.</p><p><strong>Kesimpulan:</strong> Pelaksanaan pengabdian berjalan dengan efektif dengan peningkatan pengetahuan tentang diabetes melitus, hipertensi dan merokok dalam rangka mendukung Program Indonesia Sehat dengan Pendekatan Keluarga (PISPK), pencegahan Diabetes Mellitus, Hipertensi dan kebiasaan merokok.</p><p> </p>
SEMI–PERMEABLE MEMBRANE METHOD IN DRAINING-IMPREGNATION MODE IN THE INVESTIGATION OF OIL AND GAS COLLECTORS
Authors: Sergei Fedorovich Poverennyi  , Illia Mykhaylovych Fyk  , Olena Pavlovna Varavina  , Olena Olexandrivna Yatskevych  
Published: July 2022

In the complex of petrophysical methods for studying reservoir rocks, the semi-permeable membrane method whereby the residual water saturation and the structure of the pore space are mainly determined during the modeling of the process of produced water displacement by gas during the deposit formation, is quite widely used. In this case, the membrane operates in drainage mode. To address issues that arise during the oil and gas fields development, the reverse process is also of interest - modeling the reverse water flooding of the pore space when the gas pressure in the deposits decreases or during forced water flooding of the deposits, or when studying the processes of selective water flooding of wells. In this case, the membrane should work in the drainage mode for the first part of the experiment, creating residual water saturation, and.it should work in the impregnation mode fo rthe second part of theex periment. The drainage mode is described in sufficient detail in the literature, there are practically no materials on reverse impregnation. The carried out work was aimed at developing a semi-permeable membrane method for the drainage-impregnation regime to the extent of practical use, including carryingouta small number of test studies. The developed methodology will be explained in complete detail in the corresponding methodological manual, mainly its problematic aspects are considered here. Further application of the developed methodology will be aimed at solving specific problems arising in the process of hydrocarbon deposits development. Among the priority objects of study are the processes of gas displacement by oil from oil banks, oil displacement by water, oil and gas mixture displacement during the cycling process.
ACTIVATION METHOD OF CADMIUM TELLURIDE THIN FILMS FOR CREATION EFFECTIVE SOLAR CELLS
Authors: Khrypunov Maxim , Khrypunov Gennadiy , Dobrozhan Andrii , Shelest Tetiana , Kryvonis Svitlana 
Published: July 2022

The influence of annealing in freon on the cadmium telluride films crystal structure obtained by closed space sublimation method and the output parameters and light diode characteristics of solar cells based on these films were studied. Annealing of structures was performed at a temperature of 400°С for different times. The studies of the crystal structure were performed by the X-ray diffraction analysis. These studies have shown that the annealing in freon leads to a recrystallization of cadmium telluride films, which reduces microstress. It is evidenced by the lattice period decrease after annealing from а = 6.491 Å to а = 6.488 Å. The study of the influence of annealing in freon on the output parameters and light diode characteristics of solar cells was performed. For this purpose the light current-voltage characteristics of ITO/SnO2/CdS/CdTe structures, annealed for 20‑40 minutes, were studied. It was found that the optimal annealing time in freon is 30 minutes. It is shown that the solar cells based on such films have the highest efficiency in 11.7% after annealing in freon for 30 minutes. A simulation of light diode characteristics influence on the efficiency showed that the solar cells efficiency increase due to the diode saturation current density decrease when the annealing time in freon increases to 30 minutes. When the annealing time increases to 40 minutes the efficiency decrease is associated with a shunt resistance decrease. It is also shown that the pre-irradiation of solar cells in the AM1.5 mode for 20 minutes leads to an additional efficiency increase to 12.2%. According to the simulation results, such efficiency increase is also due to the diode saturation current density decrease.
Prevalence of Occupational Exposure to HIV and Factors Associated with Compliance with Post-Exposure Prophylaxis Among Health Workers of the Biyem-Assi, Buea, and Limbe Health Districts of Cameroon Maternal and Child Health and AIDS
Authors: Esum Mathias Eyong , Nwana Yvette Ngwe , Ngwayu Claude  Nfuksai , Lum Loveline Niba , Akoachere Akoachere Jane-Francis 
Published: July 2022

Background: Although a few studies have assessed occupational exposure and knowledge on post-exposure prophylaxis (PEP) for HIV among health care workers (HCWs), limited information is available on the factors that influence the use of HIV PEP among HCWs after occupational exposure in Cameroon. This study aimed to assess the prevalence and determinants of occupational exposure to HIV infection and identify factors (knowledge, attitudes, and practices) that influence compliance to the use of HIV PEP among HCWs in the Biyem-Assi, Buea, and Limbe health districts.
Methods: A stratified cross-sectional study was carried out among health care workers from the Biyem-Assi, Buea, and Limbe health districts of Cameroon. A structured questionnaire adapted from previous studies was administered on the socio-demographic status, occupational exposure to biological agents as well as information on knowledge, awareness of PEP guidelines, attitude, and practice of the HCWs towards HIV PEP.
Results: Of the 312 participants, 198 (63.5%) experienced an occupational injury, and 240 (76.9%) had a good attitude towards HIV PEP. Age, place of work, and inadequate knowledge were determinants of occupational exposure. Whereas, awareness of PEP guidelines and being a medical doctor influenced compliance with HIV PEP, with 158 (51.0%) having adequate knowledge of the guidelines. Out of the 198 who experienced occupational injury, 114 (57.6%) adopted the good practice and 60 (30.3%) made use of HIV PEP.
Conclusion and Global Health Implications: Over half of health care workers had occupational exposure to HIV with poor utilization of post-exposure prophylaxis though they were aware and knowledgeable of PEP guidelines and exhibited good practice. Compliance with HIV PEP utilization was influenced by gender, awareness of PEP guidelines, and specialty of the health care worker.

Copyright © 2022 Eyong et al. Published by Global Health and Education Projects, Inc. This is an open-access article distributed under the terms of the Creative Commons Attribution License CC BY 4.0.
Gujin Dan is a Chinese medicine formulation that stimulates cell proliferation and differentiation by controlling multiple genes involved in MC3T3-E1 cells﻿
Authors: Zhou Yu , Liu Chaozong , Zhou Zhenwei , Li Xin , Su Songchuan , Ng Liqi , Zhong Jinghong , Wang Ting-ting , Su Wenlong , Yang Jie , Peng Zeyu , Zhang Shanyong , Yao Baojin 
Published: July 2022

Abstract
Background: With the development of Traditional Chinese medicine (TCM) in recent years, the use of TCM in the treatment of osteoporosis has received much attention and research. Gujin Dan (GJD) is one of the representative Chinese medicine formulations that work synergistically with 19 herbs and has been used for decades to treat cervical spondylosis, lumbar disc herniation, osteoarthritis and osteoporosis. However, the exact molecular mechanism by which GJD is used to strengthen bones in the treatment of osteoporosis remains largely unknown. Methods: In this study, an aqueous extract of GJD was prepared and its components were identified by high-performance liquid chromatography (HPLC). The effect of GJD aqueous extract on MC3T3-E1 cells was determined by Cell Counting Kit-8 (CCK-8) assay, alkaline phosphatase (ALP), and alizarin red S staining (ARS), combined with RNA sequencing (RNA-seq) and qRT-PCR. Results: Our study showed that GJD significantly promoted the proliferation of MC3T3-E1 cells, as well as the synthesis and mineralisation of the extracellular matrix. GJD significantly increased the expression levels of genes that promote cell proliferation such as Adamts1, Mcam, Cyr61, Fos, Cebpd, Fosl2, Sirt1, Nipbl, Sema3c and Kcnq1ot1, up-regulated genes that inhibit apoptosis such as Gadd45a, Birc3, up-regulated genes that inhibit osteoclastogenesis such as Bcl6, Nfkbiz, Clcf1, Bcl3, Lgals3, Wisp1, Dusp1 and Fblim1, up-regulated genes that promote MC3T3-E1 cell differentiation such as Junb, Egr1, Klf10, Atf6, Malat1, Btg2, Sertad4, Zfyve16, Tet2, Creb5, Snai2, Fam46a, Calcrl and Pdzrn3. In addition, GJD mildly upregulated the expression levels of gene markers such as Atf4, Fn1, Usp7, Sox4, Col16a1, Spp1, Bmp1, Runx2, Bglap, Col12a1, and Alpl in osteoblasts. Conclusions: Our results show that GJD promotes the differentiation and proliferation of MC3T3-E1 cells, inhibits osteoclast formation, and prevents osteoblast apoptosis. The present study significantly improves the current understanding of the molecular effects of GJD on MC3T3-E1 cells. This study also provides a new strategy for the further use of Chinese medicinal preparations against bone metabolism-related diseases.
Identification and validation of immune-related genes and immune cell infiltration in preeclampsia
Authors: Chen Rongxin , Han Qing , Zhang Huale , Yan Jianying 
Published: July 2022

Abstract
Preeclampsia (PE) is a complex multisystem disease, and its etiology remains unclear. The aim of this study was to identify potential immune-related diagnostic genes for PE, analyze the role of immune cell infiltration in PE. We used the dataset GSE25906 from Gene Expression Omnibus and immune-related genes from the ImmPort database. The differentially expressed genes (DEGs) were identified using the “limma” package, and the differentially expressed immune-related genes (DEIGs) were extracted from the DEGs and immune-related genes using Venn diagrams. The potential functions of DEIGs were determined. Furthermore, the protein–protein interaction network was obtained from the STRING database, and it was visualized using the Cytoscape software. Least absolute shrinkage and selection operator logistic regression and seven machine learning algorithms were used to verify the diagnostic markers of PE and build a predicting model. The model was validated using datasets GSE66273 and GSE75010. Finally, CIBERSORT was used to evaluate the infiltration of immune cells in PE tissues. Six genes (ACTG1, ENG, IFNGR1, ITGB2, NOD1, and SPP1) were identified. Datasets GSE66273 and GSE75010 were used to validate the model, and the area under the curve was 0.77 and 0.82, respectively. Immune cell infiltration analysis revealed an increase in plasma cells and gamma delta T cells and a decrease in resting natural killer cells in the high score group according to the predictive model risk values. We developed a risk model to predict PE and proved that immune imbalance at the maternal–fetal interface plays a key role in the pathogenesis of PE.
CLUSTER: A biomarker-integrated targeted therapy study in patients with advanced non-small cell lung cancer
Authors: Zhou Qing , Chen Hua-Jun , Wang Bin-Chao , Wang Zhen , Tu Hai-Yan , Xu Chong-Rui , Zheng Ming-Ying , Bai Xiao-Yan , Sun Yue-Li , Yan Hong-Hong , Gan Bin , Tao Hong , Wang Yingying , Zhao Sylvia , Yang Jin-Ji , Lai Clinton , Wu Yi-Long 
Published: July 2022

Abstract
PurposeTo better understand the relevance of genomic characteristics of NSCLC for the management of advanced NSCLC in Chinese patients, the phase II CLUSTER umbrella trial simultaneously investigated the efficacy of multiple targeted therapies in Chinese patients with advanced non-small cell lung cancer and pre-specified genetic alterations. MethodsCLUSTER was an open-label, umbrella design study with four treatment arms. Capmatinib (METi), ceritinib (ALKi), binimetinib (MEKi), and alpelisib (PI3Kai) monotherapies were investigated in previously treated patients with advanced NSCLC and matched genetic alterations. The primary endpoint for all treatment arms was overall response rate (ORR) per RECIST v1.1. Although not a predefined endpoint, a post-hoc analysis of the overall anti-tumor activity in all treated patients enrolled in the study was also performed. ResultsCeritinib met the pre‑specified statistical threshold for efficacy with an ORR of 73%, whereas an ORR of 19% and 9% were attained with capmatinib and binimetinib, respectively. The overall anti-tumor activity in all treated patients showed encouraging results. ConclusionDespite the limited number of patients in some of the treatment arms and the stringent criteria for preliminary activity, these findings confirm the feasibility of conducting biomarker-integrated studies in China, and warrant the implementation of further umbrella trials to simultaneously evaluate the efficacy of multiple targeted treatments.Trial registrationClinicalTrials.gov, NCT02276027 Registered 27 October 2014 - Retrospectively registeredhttps://clinicaltrials.gov/ct2/show/NCT02276027
Pyloric Balloon Dilation Guided by Digital Subtraction Angiography for Postsurgical Gastroparesis Syndrome is More Effective than Conservative Medical Treatment
Authors: ping guo wei , hua Chen wen , qi Wang 
Published: July 2022

Abstract
Purpose
To compare the clinical efficacy of pyloric balloon dilation guided by digital subtraction angiography (DSA) with conservative medical treatment for treating postsurgical gastroparesis syndrome (PGS).
Materials and Methods
We reviewed the data of 41 patients with PGS treated with pyloric balloon dilation guided by DSA or conservative medical treatment from January 2012 to February 2021. The median follow-up period was 588 (experimental group) and 626 days (control group). The average length of stay (ALOS) was compared between the two groups.
Results
After pyloric balloon dilation guided by DSA, all 21 patients in the experimental group resumed normal eating within 1–2 days. Upper gastroenterography confirmed good gastrointestinal motility in all 21 patients; all were discharged within 1 week. All 20 patients in the control group received conservative medical treatment; gastrointestinal peristalsis was gradually restored, abdominal distention and vomiting improved, and gastrointestinal fluid drainage gradually reduced to under 400mL/d within 20–48 days. The ALOS in the experimental group (10.2 ± 1.3 days) was significantly shorter than that in the control group (34.5 ± 14.2 days).
Conclusions
Compared with conservative medical treatment, pyloric balloon dilation guided by DSA has better clinical efficacy in the treatment of PGS and can be used as first-line treatment for PGS. However, the mechanism of action remains unclear and requires further investigation.
WITHDRAWN: Performance Evaluation of Fiber-reinforced Ferroconcrete Composite Using Response Surface Methodology-based Model for Prediction
Authors: Awolusi Temitope Funmilayo , Ekhasomhi Alenoghena I. , Aluko Oluwatobi Gbenga , Akinkurolere Olanike Olufunke 
Published: July 2022

Abstract
Research on the reuse of construction wastes has received massive thoughtfulness in the last few decades due to the advantage of natural resources conservation, construction costs, environmental benefits, and enabling the production of eco-sustainable construction materials. Fiber-reinforced ferroconcrete is a new generation type of concrete with effective performance. In this study, the fiber-reinforced ferroconcrete contains waste aluminum fiber, cement, ceramic waste powder, corrugated wire mesh, and fine and coarse aggregate. The cement content in the concrete mix were partially replaced with ceramic powder and aluminum fibers added in proportions of 0%, 10%, 20%, and 0%, 1%, and 2% to the concrete mix, respectively. The variation of both ceramic powder and aluminum fibers was done using the central composite design of Response Surface Methodology(RSM) to improve the performance of concrete through mechanical characteristics. The results show that at a 20% proportion of ceramic powder and 1% aluminum fiber, there was an increase in the compressive strength, flexural strength, and split tensile strength more than conventional concrete, with the ferroconcrete having strengths of 15.88 N/mm2, 6.68 N/mm2, and 3.83 N/mm2 respectively. Based on the independent variables (Aluminum fiber and Ceramic powder) considered, the Response surface methodology models were used to predict the responses. The results of the predicted data show a straight-line linear progression as the coefficient of determination (R2) tends to 1, indicating suitable model for predicting the response of the variables on the fiber-reinforced ferroconcrete.
Understanding the ups and downs, application of hydrologic restoration measures for a large Subtropical Lake.
Authors: Julian Paul , Welch Zach 
Published: July 2022

Abstract
Hydrologic regimes in shallow lakes strongly influence the system’s function and ecology. Changes in water levels can have nonlinear, disproportionate effects in these low gradient systems. High water levels can submerge upper elevation littoral areas, degrade benthic habitats, and redistribute sediments and nutrients throughout the lake. When water levels are low, wetland littoral areas are dried out, prompting shifts in plant communities. Lake Okeechobee, a large shallow lake, is a diverse and complex ecosystem managed for multiple purposes. Currently, water levels within the lake are managed based on the Lake Okeechobee Regulation Schedule of 2008, which is being replaced due to the completion of key restoration projects. The new regulation schedule, Lake Okeechobee System Operating Manual (LOSOM), updates water management rules while attempting to balance the needs of downstream systems; salinity and water quality in the Caloosahatchee and Saint Lucie estuaries, and more water for the southern Everglades. This study evaluates LOSOM relative to ecologically significant performance measures for the lake. Overall, the proposed regulation schedule is expected to cause deeper average lake levels, increased occurrence of damaging high-stage events, and reduced frequency of low-stage events. While decreases in the severity and frequency of low stages will be beneficial, increases in high stages may impact the long-term ecology of the system. As lake management shifts to optimize restoration efforts around and downstream of Lake Okeechobee, restoration projects upstream of the lake become critical to building and improving resilience in this central South Florida ecosystem.