bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mixed methods systematic review of the literature base exploring working alliance in the chiropractic profession
Authors: Ivanova Dima , Bishop Felicity L. , Newell Dave , Field Jonathan , Walsh Madeleine 
Published: September 2022

Abstract
Background
The construct of working alliance has been used to operationalise the patient–clinician relationship. Research evidence from the rehabilitation literature has established an association between the construct and several patient outcomes. The aim of this systematic literature review was to study working alliance in the chiropractic discipline.

Method
This review followed a mixed method systematic review methodology: EBSCO (The Allied and Complementary Medicine Database), EBSCO (MEDLINE), EBSCO PsycINFO, Web of Science Core Collection, Chiro index, and grey literature were searched for quantitative, qualitative, and mixed methods studies on 17th March 2021. Qualitative appraisal was conducted using the Mixed Methods Appraisal Tool, version 2018. The qualitative component was synthesised via thematic synthesis and explored patients’ and chiropractors’ perceptions of the nature and role of working alliance. The quantitative component was synthesised via narrative synthesis to examine how the construct has been measured in research and what its effect on clinical outcomes and patient satisfaction is. The findings were integrated in the discussion section.

Results
Thirty studies were included. The qualitative component found that both patients and chiropractors consider working alliance as a key factor in the treatment journey. The findings illustrated that the construct includes the bond between a patient and a chiropractor which is underpinned by trust and attentiveness to patients’ needs, values and preferences. Qualitative data also suggested that strong working alliance has the potential to improve patients’ adherence to treatment and that it is characterised by ongoing negotiation of expectations about the goals of care and the tasks involved in the treatment plan. The quantitative component highlighted that even though working alliance is relevant to the chiropractic discipline, very few studies have quantitatively measured the construct and its effect.

Conclusion
The findings of this review emphasise the subjective importance of working alliance in the chiropractic clinical encounter. However, there were not enough homogenous studies measuring the effect of working alliance on clinical outcomes and patient satisfaction to conduct a meta-analysis. Future research should focus on evaluating potential direct and mediated effects on patient outcomes.
Efficacy and safety of Jin-shui Huan-xian granule for idiopathic pulmonary fibrosis: study protocol for a multicenter, randomized, double-blind, placebo-controlled trial
Authors: Yang Shu-guang , Yu Xue-qing , Li Jian-sheng , Xie Yang , Zhang Wei , Ban Chengjun , Feng Jihong , Wu Lei , Lu Xuechao , Zhao Limin , Meng Yong , Zhou Miao , He Yong , Luo Weixian 
Published: September 2022

Abstract
Background and rationale
Idiopathic pulmonary fibrosis is a critical disease with a poor prognosis. Although different studies have been conducted for the treatment of idiopathic pulmonary fibrosis, limited treatments are available. Jin-shui Huan-xian granule (JHG), which is a Chinese medicine herbal compound, has shown promising efficacy in reducing frequencies of acute exacerbations, improving exercise capacity the quality of life of patients with idiopathic pulmonary fibrosis. This study is to evaluate the efficacy and safety of JHG for IPF.

Subjects and methods
This is a multicenter, randomized, double-blind, placebo-controlled clinical trial. A total of 312 idiopathic pulmonary fibrosis patients will be enrolled and randomly allocated to one of the two groups with 1:1. After a 2-week washout period, 52-week treatment will also be performed for all the patients. Patients in the experimental group and the control group will be given JHG and JHG placebo, respectively. Outcome measures including acute exacerbations, pulmonary function, dyspnea, exercise capacity, and quality of life will be evaluated in this study.

Discussion
Based on our previous study, it is hypothesized that JHG will reduce acute exacerbations; improve exercise capacity, pulmonary function, and quality of life; and delay the disease progression-free. High-level evidence-based support for TCM in IPF will also be obtained in this study.

Trial registration
ClinicalTrials.gov NCT04187690. Register on December 11, 2019
An overview of Internal Medicine Point-of-Care Ultrasound rotations in Canada
Authors: Gaudreau-Simard Mathilde , Wiskar Katie , Kilabuk Elaine , Walsh Michael H. , Sattin Michael , Wong Jonathan , Burhani Zain , Arishenkoff Shane , Yu Jeffrey , Lam Ada W. , Ma Irene W. Y. 
Published: September 2022

Abstract
Background
Point-of-care ultrasound (POCUS) is a growing part of internal medicine training programs. Dedicated POCUS rotations are emerging as a particularly effective tool in POCUS training, allowing for longitudinal learning and emphasizing both psychomotor skills and the nuances of clinical integration. In this descriptive paper, we set out to review the state of POCUS rotations in Canadian Internal Medicine training programs.

Results
We identify five programs currently offering a POCUS rotation. These rotations are offered over two to thirteen blocks each year, run over one to four weeks and support one to four learners. Across all programs, these rotations are set up as a consultative service that offers POCUS consultation to general internal medicine inpatients, with some extension of scope to the hospitalist service or surgical subspecialties. The funding model for the preceptors of these rotations is predominantly fee-for-service using consultation codes, in addition to concomitant clinical work to supplement income. All but one program has access to hospital-based archiving of POCUS exams. Preceptors dedicate ten to fifty hours to the rotation each week and ensure that all trainee exams are reviewed and documented in the patient’s medical records in the form of a consultation note. Two of the five programs also support a POCUS fellowship. Only two out of five programs have established learner policies. All programs rely on In-Training Evaluation Reports to provide trainee feedback on their performance during the rotation.

Conclusions
We describe the different elements of the POCUS rotations currently offered in Canadian Internal Medicine training programs. We share some lessons learned around the elements necessary for a sustainable rotation that meets high educational standards. We also identify areas for future growth, which include the expansion of learner policies, as well as the evolution of trainee assessment in the era of competency-based medical education. Our results will help educators that are endeavoring setting up POCUS rotations achieve success.
The effects of technological and traditional feedback on back squat performance in untrained women
Authors: Stien N. , Andersen V. , Engelsrud G. H. , Solstad T. E. J. , Saeterbakken A. H. 
Published: September 2022

Abstract
Background
Recently, a novel method for improving movement quality called open-ended augmented feedback has been introduced. However, the effects of using such feedback in a training intervention have not yet been examined. The aim of this study was to assess the changes in performance and movement quality following a five-week resistance-training program with either (1) technological feedback or (2) traditional, verbal feedback from an experienced trainer.

Methods
Nineteen untrained females (age: 21.84 ± 2.24 years, height: 169.95 ± 5.92 cm, body mass: 65.05 ± 7.93 kg) randomly allocated to one of the two conditions completed five weeks of training with two weekly sessions. Pre- and post-intervention, participants were tested for physical performance (i.e., back squat and isometric mid-thigh pull strength) and movement quality parameters (weight distribution, center of gravity variation, and subjective rating of the back squat technique).

Results
Both groups similarly increased the training resistance throughout the intervention (p < 0.01), as well as strength in the back squat (technological feedback group: effect size (ES) = 1.31, p = 0.002; traditional feedback group: ES = 1.48, p = 0.002). Only the traditional feedback group increased isometric mid-thigh pull strength (ES = 1.11, p = 0.008) and subjectively rated lifting technique at the same load (p = 0.046). No changes in force distribution (p = 0.062–0.993) or center of gravity variation (p = 0.160–0.969) occurred in either group when lifting the same absolute loads at post-test. However, both groups displayed a greater variation in center of gravity when lifting the same relative load at post-test (technological feedback group: p < 0.001; traditional feedback group: p = 0.006). No differences were found between the groups for any of the observed changes (p = 0.205–0.401).

Conclusions
Five weeks of back-squat training with verbal feedback increased isometric mid-thigh pull strength and subjectively rated lifting technique from pre- to post-test, whereas technological feedback did not. Both methods improved back squat strength and training resistance. For resistance-training beginners, the choice between feedback methods should be based on the desired outcomes and the availability of expertise and equipment.
Pastoral practices, pressures, and human-wildlife relations in high altitude rangelands of eastern Himalaya: A case study of the Dokpa pastoralists of North Sikkim
Authors: Luxom Nisam Mang , Singh Rashmi , Theengh Laktsheden , Shrestha Priyadarshinee , Sharma Rishi Kumar 
Published: September 2022

AbstractThe pastoral practices of the Dokpa herders of North Sikkim have been transforming in response to the geo-political and socio-economic changes in the region. Against the backdrop of these changes, this study aims to understand the current state of pastoralism in North Sikkim with three specific objectives: (i) to understand the current rangeland management practices of the Dokpa community; (ii) to examine the social, political and ecological stresses to continuity of traditional pastoral livelihoods; and (iii) to document the baseline on human-wildlife relations. We focused on one of the two subset populations of Dokpa herders of North Sikkim and, using a mixed-methods approach, conducted 12 semi-structured interviews, four key respondent interviews and two focused group discussions. The resource use by the Dokpas is unique, and unlike the rest of the Himalayan range, they access the high-altitude pastures in winters and the lower ones in summer. Pastures in the higher altitudes experience heavier winds, which leads to lower levels of snow deposition — thus ensuring access to dried pasture forage for livestock during the lean season. The decisions pertaining to resource management are taken by the head of the local institution Dzumsa, the Pipon. Primary stresses to the continuation of traditional pastoral practices are fragmentation of pastureland post-Sino-Indian war of 1962 and the consequent establishment of armed forces, livestock depredation by free-ranging dogs followed by wild predators and continued socio-economic marginalisation of the pastoralists under a supposedly egalitarian institutional regime. Extreme climatic events in the recent past have also contributed to significant livestock loss. Dokpa transhumant practices are on an overall decline, with most members of the younger generation shifting to non-herding livelihoods. The availability of alternate livelihood options with the improved connectivity, access to education and development of the tourism industry has led to changing aspirations of the younger generations. In only two of the twelve households we surveyed, the younger generation continues herding, while the rest have moved to the cities and towns. In terms of human-wildlife relations, the respondents mostly hold a positive attitude towards wildlife and conservation actions despite livestock predation by wild predators, since the free-ranging dogs cause the highest livestock loss. With the inputs from the Dokpas, we provide recommendations towards a facilitative environment for the continuation of the traditional herding in the region, which is critical for the survival of pastoralism in North Sikkim, presently hinged on less than two dozen of elderly Dokpas.
The therapeutic prospects and challenges of human neural stem cells for the treatment of Alzheimer's Disease
Authors: Yue Chunmei , Feng Su , Chen Yingying , Jing Naihe 
Published: September 2022

AbstractAlzheimer's disease (AD) is a multifactorial neurodegenerative disorder associated with aging. Due to its insidious onset, protracted progression, and unclear pathogenesis, it is considered one of the most obscure and intractable brain disorders, and currently, there are no effective therapies for it. Convincing evidence indicates that the irreversible decline of cognitive abilities in patients coincides with the deterioration and degeneration of neurons and synapses in the AD brain. Human neural stem cells (NSCs) hold the potential to functionally replace lost neurons, reinforce impaired synaptic networks, and repair the damaged AD brain. They have therefore received extensive attention as a possible source of donor cells for cellular replacement therapies for AD. Here, we review the progress in NSC-based transplantation studies in animal models of AD and assess the therapeutic advantages and challenges of human NSCs as donor cells. We then formulate a promising transplantation approach for the treatment of human AD, which would help to explore the disease-modifying cellular therapeutic strategy for the treatment of human AD.
Aldehyde dehydrogenase 2 rs671 polymorphism and multiple diseases: protocol for a quantitative umbrella review of meta-analyses
Authors: He Zhengting , Guo Qi , Ling Yikai , Hong Chuan , Liu Yuqing , Jin Xurui , Thanaporn Porama , Zhao Duan , Wang Leiting , Liu Liang , Yan Lijing L. 
Published: September 2022

Abstract
Background
The mutant allele (*2) of aldehyde dehydrogenase type 2 (ALDH2) caused by a single nucleotide variant (rs671) inhibits enzymatic activity and is associated with multiple diseases. In recent years, an explosive number of original studies and meta-analyses have been conducted to examine the associations of ALDH2 rs671 polymorphism with diseases. Due to conflicting results, the overall associations of ALDH2 rs671 polymorphism and multiple diseases remain unclear.

Methods
A quantitative umbrella review will be conducted on meta-analyses of genetic association studies to examine the pleiotropic effects of ALDH2 rs671, mainly including cardio-cerebral vascular disease, diabetes mellitus, cancer, neurodegenerative disease, and alcohol-induced medical disease. A search of relevant literature according to comprehensive search strategies will be performed on studies published before July 1st, 2022 in PubMed, MEDLINE Ovid, Embase, Cochrane Database of Systematic Reviews, and Web of Science. Study selection, data extraction, methodology quality assessment, and strength of evidence assessment will be conducted by two reviewers independently and in duplicate. Included meta-analyses will be grouped by outcomes. Data conflicts and overlap between meta-analyses will be managed through updated standardized and customized methods including the calculation of CCA for study selection reference, application of Doi plots to assess small-study effects and others. Evidence from included meta-analyses will be quantitatively synthesized by overlap-corrected analyses and meta-analysis using primary studies.

Discussion
This umbrella review is expected to generate systematic evidence on the association between ALDH2 rs671 and diseases. Specific approaches were developed to address key challenges in conducting an umbrella review, including assessment tools of methodology and evidence quality of meta-analyses, methods to manage overlap between meta-analyses, a “stop-light” plot to summarize key findings. These approaches provide applicable methods for future umbrella reviews of meta-analyses on genetic association studies.

Trial registration
CRD42021223812
Duration of immunity following full vaccination against SARS-CoV-2: a systematic review
Authors: Addo Isaac Yeboah , Dadzie Frederick Asankom , Okeke Sylvester Reuben , Boadi Caleb , Boadu Elijah Frimpong 
Published: September 2022

Abstract
Background
As vaccine roll-out continues across the globe as part of the efforts to protect humanity against SARS-CoV-2, concerns are increasingly shifting to the duration of vaccine-induced immunity. Responses to these concerns are critical in determining if, when, and who will need booster doses following full vaccination against SARS-CoV-2. However, synthesised studies about the durability of vaccine-induced immunity against SARS-CoV-2 are scarce. This systematic review synthesised available global evidence on the duration of immunity following full vaccination against SARS-CoV-2.

Methods
We searched through Psych Info, Web of Science, Scopus, Google Scholar, PubMed, and WHO COVID-19 databases for relevant studies published before December 2021. Five eligibility criteria were used in scrutinising studies for inclusion. The quality of the included studies was assessed based on Joana Briggs Institute’s (JBI) Critical Appraisal tool and Cochrane’s Risk of Bias tool—version 2 (RoB 2), while the reporting of the results was guided by the Synthesis Without Meta-analysis (SWiM) guidelines.

Results
Twenty-seven out of the 666 identified studies met the inclusion criteria. The findings showed that vaccine-induced protection against SARS-CoV-2 infections builds rapidly after the first dose of vaccines and peaks within 4 to 42 days after the second dose, before waning begins in subsequent months, typically from 3 to 24 weeks. Vaccine-induced antibody response levels varied across different demographic and population characteristics and were higher in people who reported no underlying health conditions compared to those with immunosuppressed conditions.

Conclusions
Waning of immunity against SARS-CoV-2 begins as early as the first month after full vaccination and this decline continues till the sixth month when the level of immunity may not be able to provide adequate protection against SARS-CoV-2. While the evidence synthesised in this review could effectively inform and shape vaccine policies regarding the administration of booster doses, more evidence, especially clinical trials, are still needed to ascertain, with greater precision, the exact duration of immunity offered by different vaccine types, across diverse population characteristics, and in different vulnerability parameters.

Registration
The protocol for this review was pre-registered with the International Prospective Register of Systematic Reviews [PROSPERO] (Registration ID: CRD420212818).
Characterization of ACE2 naturally occurring missense variants: impact on subcellular localization and trafficking
Authors: Badawi Sally , Mohamed Feda E. , Alkhofash Nesreen R. , John Anne , Ali Amanat , Ali Bassam R. 
Published: September 2022

AbstractBackgroundHuman angiotensin-converting enzyme 2 (ACE2), a type I transmembrane receptor physiologically acting as a carboxypeptidase enzyme within the renin-angiotensin system (RAS), is a critical mediator of infection by several severe acute respiratory syndrome (SARS) corona viruses. For instance, it has been demonstrated that ACE2 is the primary receptor for the SARS-CoV-2 entry to many human cells through binding to the viral spike S protein. Consequently, genetic variability in ACE2 gene has been suggested to contribute to the variable clinical manifestations in COVID-19. Many of those genetic variations result in missense variants within the amino acid sequence of ACE2. The potential effects of those variations on binding to the spike protein have been speculated and, in some cases, demonstrated experimentally. However, their effects on ACE2 protein folding, trafficking and subcellular targeting have not been established.ResultsIn this study we aimed to examine the potential effects of 28 missense variants (V801G, D785N, R768W, I753T, L731F, L731I, I727V, N720D, R710H, R708W, S692P, E668K, V658I, N638S, A627V, F592L, G575V, A501T, I468V, M383I, G173S, N159S, N149S, D38E, N33D, K26R, I21T, and S19P) distributed across the ACE2 receptor domains on its subcellular trafficking and targeting through combinatorial approach involving in silico analysis and experimental subcellular localization analysis. Our data show that none of the studied missense variants (including 3 variants predicted to be deleterious R768W, G575V, and G173S) has a significant effect on ACE2 intracellular trafficking and subcellular targeting to the plasma membrane.ConclusionAlthough the selected missense variants display no significant change in ACE2 trafficking and subcellular localization, this does not rule out their effect on viral susceptibility and severity. Further studies are required to investigate the effect of ACE2 variants on its expression, binding, and internalization which might explain the variable clinical manifestations associated with the infection.
“The male elephant in the room”: a qualitative evidence synthesis exploring male experiences of eating disorders
Authors: Coopey Emily , Johnson George 
Published: September 2022

Abstract
Background
Men are believed to be underrepresented in eating disorder services; there are many reasons presented to account for this such as a lack of recognition and detection. Due to the physical and psychological complexity of an eating disorder it is important to understand this underrepresentation. This qualitative evidence synthesis aimed to explore the literature relating to men’s experiences of an eating disorder, in order to synthesise the findings and offer a more coherent understanding.

Method
A systematic search of the literature was undertaken. Inclusion and exclusion criteria were applied to the findings resulting in 14 papers deemed suitable for inclusion. A Meta-Ethnographic approach to synthesising the data of the 89 participants was undertaken.

Results
Four themes were identified: ‘Societal Construction of the Perfect Male’; ‘Striving to Maintain a Masculine Identity’; ‘The Interconnectedness of Control and Self-Worth’, and ‘The Hidden Man’. There appeared to be an underlying concept relating to the conflict of being a man, with what is perceived to be a ‘woman’s illness’ and how this challenged the men’s experiences of masculinity.

Conclusions
Being a man with an eating disorder conflicted with societal norms, exacerbating their experience of having an eating disorder.. To resolve this, gendered norms need to shift, at societal level as well as considering how best to improve understanding and recognition of men with an eating disorder at the first point of help seeking.