bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development and validation of nomograms by radiomic features on ultrasound imaging for predicting overall survival in patients with primary nodal diffuse large B-cell lymphoma
Authors: Deng Hongyan , Zhou Yasu , Lu Wenjuan , Chen Wenqin , Yuan Ya , Li Lu , Shu Hua , Zhang Pingyang , Ye Xinhua 
Published: December 2022

ObjectivesTo develop and validate a nomogram to predict the overall survival (OS) of patients with primary nodal diffuse large B-cell lymphoma(N-DLBCL) based on radiomic features and clinical features.Materials and methodsA retrospective analysis was performed on 145 patients confirmed with N-DLBCL and they were randomly assigned to training set(n=78), internal validation set(n=33), external validation set(n=34). First, a clinical model (model 1) was established according to clinical features and ultrasound (US) results. Then, based on the radiomics features extracted from conventional ultrasound images, a radiomic signature was constructed (model 2), and the radiomics score (Rad-Score) was calculated. Finally, a comprehensive model was established (model 3) combined with Rad-score and clinical features. Receiver operating characteristic (ROC) curves were employed to evaluate the performance of model 1, model 2 and model 3. Based on model 3, we plotted a nomogram. Calibration curves were used to test the effectiveness of the nomogram, and decision curve analysis (DCA) was used to asset the nomogram in clinical use.ResultsAccording to multivariate analysis, 3 clinical features and Rad-score were finally selected to construct the model 3, which showed better predictive value for OS in patients with N-DLBCL than mode 1 and model 2 in training (AUC,0. 891 vs. 0.779 vs.0.756), internal validation (AUC, 0.868 vs. 0.713, vs.0.756) and external validation (AUC, 914 vs. 0.866, vs.0.789) sets. Decision curve analysis demonstrated that the nomogram based on model 3 was more clinically useful than the other two models.ConclusionThe developed nomogram is a useful tool for precisely analyzing the prognosis of N-DLBCL patients, which could help clinicians in making personalized survival predictions and assessing individualized clinical options.
Concurrent chemoradiotherapy followed by adjuvant chemotherapy versus concurrent chemoradiotherapy alone in locally advanced cervical cancer: A systematic review and meta-analysis
Authors: Liu Haonan , Ma Xiao , Sun Chenyu , Wu Meng , Xu Zhiyuan , Zhou Shuang , Yao Nan , Liu Suya , Qin Xiaobing , Han Zhengxiang 
Published: December 2022

ObjectiveThis study aimed to assess the efficacy and safety of adjuvant chemotherapy (ACT) after concurrent chemoradiation (CCRT) in patients with locally advanced cervical cancer (LACC) via meta-analysis.MethodsA systematic literature search of MEDLINE, PubMed, Web of Science, EMBASE, and the Cochrane Central Register of Controlled Trials was conducted from January 10, 1966 to May 20, 2022. Randomized controlled trials and observational studies comparing the CCRT alone with CCRT plus ACT were included. The literature search, quality assessment, and data extraction were conducted by two reviewers independently. The primary endpoints were 3-year rates of overall survival (OS) and progression-free survival (PFS). Complete response rate, local recurrence, distant metastasis, and adverse events were secondary outcomes. The hazard ratios (HRs) and relative risk (RR) were pooled.ResultsNine studies with a total of 2732 patients were included in this meta-analysis, including 1411 patients in the CCRT group and 1321 in the CCRT plus ACT group. The HR for 3-year rates of OS and PFS of the CCRT group compared with the CCRT plus ACT group was 0.72 [95%confidence interval (CI) = 0.44–1.17] and 0.78 (95%CI = 0.5–1.75), respectively. No significant differences were observed between the two groups in the complete response rate (RR = 1.06, 95%CI = 0.96–1.16). However, local recurrence and distant metastasis were significantly lower in the CCRT plus ACT group than in the CCRT group (RR = 0.63, 95%CI = 0.44 –0.91 and RR = 0.64, 95%CI = 0.47–0.88). Grade 3–4 acute toxicities were more frequent in the CCRT plus ACT group (RR = 1.73, 95%CI =1.19–2.52).ConclusionAlthough associated with a decreased risk of local recurrence and distant metastasis, ACT did not significantly improve the survival rate and the complete response rate with increasing grade 3–4 acute toxicities in patients with LACC. Thus, this ACT regimen cannot be recommended for patients with LACC.Systematic review registrationhttps://inplasy.com/inplasy-2022-9-0089/, identifier INPLASY202290089.
Effective practices for improving service professionals’ ethical behaviors: A multiple method study
Authors: Hu Ying , Yang Yefei , Lee Peter K. C. 
Published: December 2022

IntroductionEnhancing frontline professional service employees’ ethics has been an increasingly important issue for organizations in sustaining their reputation and long-term profitability. While many organizations have implemented general ethics programes such as ethics codes and ethical training, unethical scandals regularly still appear in many service organizations. This research offers new insights into the practices that can effectively enhance marketing practitioners’ ethical behaviors and the pertinent contextual factors that have a bearing on the effectiveness of ethics programes.MethodsIt uses a multi-method methodology to conduct two studies in the Chinese banking setting. Based on the rank of revenue and profitability published by Fortune magazine of year 2021, in Study 1, we choose five main Chinese banking organizations to conduct case studies to explore the framework of effective ethics programes of banks. In Study 2 we use the valid instruments from the literature to measure the involved constructs and employs data from randomly selected 146 frontline banking teams in five main Chinese banking organizations to examine the effectiveness of three specific ethics practices and ascertain the moderating role of role stress in such effectiveness.Results and discussionOur findings indicate the effective behavior control practices within organizations’ ethics programes and the implications of having a stressful workplace when adopting such practices. In addition, we integrate organizational concepts regarding behavior control and employee ethics, and use two empirical methods to systematically explore the effectiveness of ethics programes. This paper advances the management and marketing literature and has significant managerial implications for improving frontline service professionals’ ethical behaviors.
Development and validation of children's mind wandering scales
Authors: Cao Zhiwei , Huang Ying , Song Xiaolan , Ye Qun 
Published: December 2022

IntroductionMind wandering is generally considered an endogenous mental state that arises spontaneously, which is one of the most common experiences of consciousness and typically occurs at a significant cost to mental health and behavioral performance. Previous studies have shown that mind wandering appears to be a stable trait and can be assessed reliably in adults. Surprisingly little, however, is known about how to measure the frequency of mind wandering in children, given that children can accurately introspect their experiences. The present studies aimed to develop the Frequency of Children's Mind Wandering Scale (CMWS-F) and the Context of Children's Mind Wandering Scale (CMWS-C) to assess the frequency of mind wandering and contexts in which mind wandering occurs for children aged 8 to 11 years.MethodsThe exploratory factor analysis (EFA) and confirmatory factor analysis (CFA) were used to develop the CMWS-F and CMWS-C. To further assess the validity of the scales, we compared the scores in CMWS-F/CMWS-C and the frequencies of probe-caught mind wandering in the typical tasks.ResultsIn study 1a, the EFA (n = 292) and CFA (n = 346) showed that attentional failure and spontaneous thinking were the two main dimensions of CMWS-F. In study 1b, contexts about mind wandering in children could be divided into high-demand and low-demand contexts using EFA (n = 258) and CFA (n = 347). Study 2 showed moderate positive correlations between the frequencies of probe-caught mind wandering in the tasks and the scores in the scales.DiscussionThe results showed that scores on the two scales could predict the performance on the experimental tasks and further demonstrated empirical validity of the CMWS-F and CMWS-C scales. Taken together, the results of the current studies provided preliminary evidence for the validity and reliability of CMWS-F and CMWS-C in children, which can be used as a reference to balance its downsides and productive aspects of mind wandering.
Genetic analysis of neurodevelopmental disorders in children
Authors: Wu Dandan , Li Rong 
Published: December 2022

PurposeTo explore the genetic cause of children with unidentified etiology of neurodevelopmental disorders, thus providing references for the diagnosis, treatment and genetic counseling.Design and methodsChildren with neurodevelopmental disorders but unidentified etiology in the Child Healthcare Department, Children's Hospital of Nanjing Medical University from November 2018 to December 2021 were retrospectively analyzed. A total of 2 ml of peripheral venous blood was collected from the child and their parents for the whole exome sequencing (WES) and copy number variation (CNV) detection. Male children were subjected to fragile X syndrome testing to determine the genetic mutations. For those with positive results, Sanger sequencing was performed to explore the mutations in the gene sites and pedigrees.ResultsA total of 488 (33.5%) pathogenic variations were detected among 1,457 global developmental/intellectual disabilities (GDD/ID) children, including 362 (24.9%) cases of monogenic mutations, and 111 (7.6%) cases of chromosomal microdeletions or microduplications. There were 15/780 (1.92%) male children with fragile X syndrome. Single point mutations were detected in 277/362 (76.5%) and 85/362 (23.5%) male and female GDD/ID children, respectively, including 295 (81.5%) cases of missense mutations, 32 (8.8%) cases of frameshift mutations, 5 (2.2%) cases of non-sense mutations and 30 (8.3%) cases of splice site mutations. In addition, there were 166 (45.8%) cases of autosomal inheritance and 196 (54.2%) cases of X-linked inheritance. The X chromosome abnormalities were mostly observed in 362 GDD/ID children with monogenic mutations, including 15 cases of the AFF2 gene mutation, 13 cases of the MECP2 gene mutation and 12 cases of the HUWEI gene mutation. The CREBBP gene mutation was the most common autosome abnormality in GDD/ID children with monogenic mutations, which was detected in five cases. There were 74 cases of chromosomal microdeletions, 31 cases of chromosomal microduplications and six cases of both. A total of 114 novel pathogenic mutations responsible for GDD/ID were found, including four novel mutations in MECP2 and TRAPPC9 genes.ConclusionThe incidence of genetic abnormalities remains high in NDD children. Abundant novel mutations are responsible for GDD/ID in children, and can be used as references in the diagnosis of neurogenetic diseases.
Case report: Cholesterol granuloma of femur
Authors: Hao Shenshen , Dong Shengli , Li Hongke , Liu Shuai , Chen Honglei , Zhang Zhifang 
Published: December 2022

BackgroundCholesterol granuloma (CG) is a particular type of granulation tissue reaction. It is a very rare benign lesion characterized by swelling growth due to a large number of cholesterol crystals and foreign body giant cells. There has been no report of a CG of the femur.Case presentationA 74-year-old woman suffered from pain and discomfort in the upper right knee for 10 years, which became aggravated for 10 days. She was diagnosed with CG of the right femur at our hospital and was treated with surgery. During the operation, a large amount of yellow-brown, oily, crystal structures was found. Postoperative pathology investigations confirmed the lesion as a CG. Postoperative follow-up was carried out for 15 months that confirmed the effect of treatment was satisfactory.ConclusionsCG of the femur is an extremely rare benign lesion. Surgical treatment can provide effective treatment results.
GAMBARAN KADAR GLUKOSA DARAH SEWAKTU PADA LANSIA DI DESA ADAT TAMPUAGAN KECAMATAN KARANGASEM KABUPATEN KARANGASEM
Authors: Mastra Nyoman 
Published: December 2022

Background: The aging process is a factor that causes a decrease in pancreatic function cells and insulin secretion in the elderly. As a result of this aging process, the risk of increased blood glucose levels and impaired glucose tolerance will be higher.Purpose: This study aimed to find out the description of random blood glucose levels in the elderly in the Traditional Village of Tampuagan, Karangasem District, Karangasem Regency.Method: The type of research used is descriptive research with simple random sampling techniques. The sample used 39 samples obtained through interviews and checking random blood gluc.ose levels while using the glucose oxidase method using the POCT toolResult: Obtained the highest random blood glucose levels of respondents who had normal random blood glucose levels. Based on characteristics found most in the age range of 60-74 years, female gender, and no history of DM.Conclusion: The description of blood glucose levels in the elderly in the Traditional Village of Tampuagan, Karangasem District, Karangasem Regency, mostly have normal blood glucose levels. Keywords: Random Blood Glucose, Elderly, POCT.
Jogo digital para a estimulação da memória de idosos residentes em uma instituição de longa permanencia na cidade de Salvador-BA
Authors: Pires Luana Santos , Dos Santos Débora Matias 
Published: December 2022

Segundo dados do Instituto Brasileiro de Geografia e Estatísticas (IBGE), entre o ano de 2012 e 2021 o número de pessoas com 60 anos ou mais aumentou de 11,3% para 14,7%. Com o avançar da idade, ocorrem mudanças fisiológicas, sensoriais, físicas e principalmente cognitivas. O declínio de memória pode ser observado quando o idoso tem dificuldade em recuperar informações recentes. Diante de questões financeiras, psicológicas, físicas e patológicas, e visando uma melhor atenção para os idosos, muitos familiares e até os próprios idosos, optam por instituições de longa permanência. Assim como o aumento no número de idosos, é possível observar também o avanço dos recursos digitais que estão a cada dia mais presentes na vida dos mesmos. O objetivo do presente trabalho consistiu em aplicar um jogo digital para auxiliar na estimulação da memória de idosos, avaliar o nível de habilidade diante de um recurso digital, classificar a memória por meio do número de acertos e tempo de jogo e verificar o desempenho dos idosos ao manusear o aparelho digital. Trata-se de um estudo de corte transversal, realizado no Lar Franciscano Capela Santa Isabel, instituição de longa permanência para idosos (ILPI), localizado em Salvador- BA. A coleta de dados foi realizada em julho de 2022 após a aprovação do comitê de ética da Universidade Paulista (UNIP) no dia 1 de Julho de 2022, Nº 5.503.659, CAAE 59479122.0.0000.5512. Onde primeiro foi aplicado o Mini Exame de Estado Mental (MEEM) e em seguida um jogo digital através de um aplicativo online gratuito Wordwall. Após regras de seleção 23 residentes participaram da pesquisa com média de idade de 79,2; sendo 13% homens e 87% mulheres; com média de pontuação no MEEM de 20,6 e média de pontuação do jogo 12,5. Foi observado facilidade no manuseio do recurso digital, resultados do MEEM não interferiram no jogo e mulheres tiveram melhor pontuação na pesquisa.
Analisis Ukuran Lengkung Rahang Anak Usia 10-13 Tahun dan 14-16 Tahun di Wilayah Dataran Tinggi (Studi di Kecamatan Jelbuk Kabupaten Jember)
Authors: Barid Izzata , Indahyani Didin E. , Utami Sigiq E. 
Published: December 2022

Abstract: The growth and development of the arch is influenced by genetics, race, and environment. Genetic factors are the important basic in growth and development while environmental factors in the form of geographical, socio-cultural and economic locations can interact with the genetic factors. This study aimed to analyze the size of the jaw arch of children aged 10-13 years and 14-16 years at the highland of Jelbuk District, Jember Regency. This was an analytical and observational study with a cross sectional design. Measurement of the jaw arch on the model was performed using the Raberin method. The results obtained 136 subjects consisting of 59 boys and 77 girls aged 10-16 years. All subjects were grouped into two age groups, 10-13 years and 14-16 years. The Mann-Whitney U test on the difference in jaw arch size between the ages of 10-13 years and 14-16 years showed that most of them had p-values of >0.05, which meant that there was no significant difference between the two age groups, except at L31 of mandibular male. In conclusion, there is no significant difference in the size of the jaw arch of children aged 10-13 years and 14-16 years at the highland of Jelbuk District, Jember RegencyKeywords: highlands; the size of the jaw arch; growth spurts; socio-cultural; economy Abstrak: Pertumbuhan dan perkembangan lengkung rahang dipengaruhi oleh genetik, ras, dan lingkungan. Faktor genetik merupakan modal dasar dalam tumbuh kembang sedangkan faktor lingkungan berupa letak geografi, sosial budaya dan ekonomi dapat berinteraksi dengan faktor genetik. Penelitian ini bertujuan menganalisis ukuran lengkung rahang anak usia 10-13 tahun dan usia 14-16 tahun di wilayah dataran tinggi Kecamatan Jelbuk, Kabupaten Jember. Jenis penelitian ini observasional analitik dengan desain potong lintang. Pengukuran lengkung rahang pada model menggunakan metode Raberin. Hasil penelitian mendapatkan 136 subjek yang terdiri dari 59 anak laki-laki dan 77 anak perempuan berusia 10-16 tahun. Keseluruhan subjek dikelompokkan menjadi dua kelompok usia yakni usia 10-13 tahun dan usia 14-16 tahun. Berdasarkan Mann-Whitney U Test pada uji beda ukuran lengkung rahang antara usia 10-13 tahun dengan 14-16 tahun sebagian besar menunjukkan nilai p>0,05 yang artinya tidak terdapat perbedaan bermakna antara kedua kelompok usia, kecuali pada L31 rahang bawah anak laki-laki. Simpulan penelitian ini ialah tidak terdapat perbedaan bermakna dalam ukuran lengkung rahang antara kelompok usia 10-13 tahun dan 14-16 tahun di wilayah dataran tinggi Kecamatan Jelbuk, Kabupaten Jember.Kata kunci: dataran tinggi; ukuran lengkung rahang; growth spurt; sosial budaya; ekonomi
ANALISIS PENGARUH MANAJEMEN PERUBAHAN, BUDAYA ORGANISASI DAN KUALITAS KERJA TERHADAP KINERJA PEGAWAI PADA DINAS PEKERJAAN UMUM, PENATAAN RUANG, PERUMAHAN DAN KAWASAN PERMUKIMAN KABUPATEN BARITO TIMUR
Authors: Dody  , Hary Soegiri  , M. Zaid Abdurrakhman  
Published: December 2022

Abstrak: Tujuan penelitian ini adalah untuk mengetahui dan menganalisis pengaruh signifikan secara simultan manajemen perubahan, budaya organisasi dan kualitas kerja terhadap kinerja pegawai, mengetahui pengaruh signifikan secara parsial manajemen perubahan, budaya organisasi dan kualitas kerja terhadap kinerja pegawai dan untuk mengetahui variabel yang berpengaruh signifikan dominan terhadap kinerja pegawai Dinas Pekerjaan Umum, Penataan Ruang dan Kawasan Permukiman Kabupaten Barito Timur. Desain penelitian ini adalah penelitian korelasi dengan jumlah sampel sebanyak 56 responden. Data diperoleh dengan menggunakan kuisioner penelitian yang telah diuji validitas dan realibilitasnya. Metode analisis data yang digunakan adalah analisis deksriptif dan analisis regresi linier berganda dengan bantuan program SPSS versi 23. Berdasarkan hasil analisis disimpulkan bahwa secara simultan manajemen perubahan, budaya organisasi dan kualitas kerja berpengaruh signifikan terhadap kinerja pegawai. Terdapat pengaruh signifikan secara parsial manajemen perubahan, budaya organisasi dan kualitas kerja terhadap kinerja pegawai. Selain itu, variabel dominan yang paling berpengaruh signifikan terhadap peningkatan kinerja pegawai adalah variabel budaya organisasi sebesar 41,5 %, kualitas kerja memiliki pengaruh signifikan sebesar 26,7 % dan manajemen perubahan memiliki pengaruh signifikan sebesar 26,5 %. Peneliti menyarankan agar menerapkan budaya organisasi melalui petunjuk teknis dan pedoman kerja, melaksanakan pengawasan terhadap kualitas kerja pegawai dan menerapkan perubahan revolusi 4.0 dalam pelaksanaan tugas pegawai sehingga dapat meningkatkan kinerja pegawai secara optimal.
Kata-kata kunci : Manajemen Perubahan, Budaya Kerja, Kualitas Kerja dan Kinerja Pegawai
ANALISIS PERAN DAN KUALITAS SUMBER DAYA MANUSIA PERANGKAT DESA TERHADAP KINERJA DALAM PEMBEBASAN LAHAN HUTAN KONVERSI MENJADI HAK MILIK MASYARAKAT DI DESA TINGGIRAN DARAT KECAMATAN MEKARSARI KABUPATEN BARITO KUALA KALIMANTAN SELATAN
Authors: HUMAIDI HUMAIDI 
Published: December 2022

The influence of the Role and Quality of Village Human Resources on Performance in the Acquisition of Converted Forest Land into the Property of the Tinggiran Darat Village Community, Mekarsari District, Barito Kuala Regency, South Kalimantan. This study aims to determine and analyze the influence of the role and quality of human resources of village officials simultaneously on performance in the acquisition of conversion forest land into the property of the people of Tinggiran Darat Village, Mekarsari District, Barito Kuala Regency, South Kalimanta .Sources of primary data in this study is data obtained directly from respondents through a list of questions addressed to each respondent. And the respondents in this study were village officials. The method of analysis in this study is to use Multiple Linear analysis using the SPSS program. Prior to the path analysis process, the research instrument (questionnaire) was tested with validity and reliability tests as well as classical assumptions. The results all meet the criteria to be continued at the multiple linear analysis stage The Role of Village Apparatus and Quality of Human Resources Village Apparatus have a significant simultaneous effect on the Performance of Tinggiran Darat Village, Tinggiran Darat District, Barito Kuala Regency, South Kalimantan Province, Barito Kuala Regency. The correlation value shows a high level of relationship. The role of village officials has a positive and significant impact on performance in the acquisition of conversion forest land into the property of the people of Tinggiran Darat Village, Mekarsari District, Barito Kuala Regency, South Kalimantan. So that the higher the role of the village apparatus, the performance in the acquisition of conversion forest land into the property of the people of Tinggiran Darat Village, Mekarsari District, Barito Kuala Regency, South Kalimantan, will be better.

Keywords: the role of village officials, Quality of Human Resources and Performance
PENGARUH KEPUASAN KERJA DAN STRES KERJA TERHADAP TURNOVER INTENTION PEGAWAI PADA PT JASA RAHARJA CABANG KALIMANTAN SELATAN
Authors: Budi Yanuarifan Tri Utomo  
Published: December 2022

Abstrak : Penelitian ini bertujuan untuk mengetahui dan menganalisis kepuasan kerja dan stres kerja berpengaruh signifikan secara simultan, parsial dan dominan terhadap turnover intention pada PT. Jasa Raharja Cabang Kalimantan Selatan. Metode penelitian menekankan pada pembagian angket yang disebarkan kepada pihak pegawai PT. Jasa Raharja Cabang Kalimantan Selatan. Teknik analisis data menggunakan analisis regresi linear berganda. Hasil penelitian dapat disimpulkan bahwa terdapat pengaruh signifikan baik secara simultan, parsial kepuasan kerja dan stres kerja terhadap kepuasan kerja pada PT. Jasa Raharja Cabang Kalimantan Selatan.

Kata Kunci : Kepuasan Kerja, Stres Kerja, Turnover Intention