bluuebunny/crossref_metadata_2025_split huggingface dataset:
Combined influence of cross‐diffusion and variable fluid properties on free convection flow past a vertical cone
Authors: Srinivasacharya Darbhasayanam , Rajender Bhanoth 
Published: October 2022

AbstractThe free convective flow of an incompressible viscous fluid over an isothermal vertical cone with variable viscosity and variable thermal conductivity is examined in the presence of the Soret and Dufour effects. As thermal and solutal boundary conditions at the cone's surface, the constant temperature and concentration (WTC) and constant heat and mass flux (HMF) cases are taken into account. The successive linearization method is applied to linearize a system of nonlinear differential equations that describes the flow under investigation. The numerical solution for the resulting linear equations is attained by means of the Chebyshev spectral method. The obtained numerical results are compared and found to be in good agreement with previously published results. The impact of significant parameters on the heat and mass transfer rates is evaluated and presented graphically for the WTC and HMF situations. In both cases, the Soret number increases the skin friction coefficient and rate of heat transfer while decreasing the Sherwood number. With an increase in the Dufour parameter, the coefficient of skin friction and Sherwood numbers increase while the heat transmission rate decreases.
Differential etiopathogenic features of vulvar squamous cell carcinomas in sub‐Saharan Africa and Europe
Authors: Rakislova Natalia , Carreras‐Dieguez Nuria , Manzotti Carolina , Saúde Ofelia , del Pino Marta , Chulo Laurina , Rangeiro Ricardina , Lovane Lucilia , Lorenzoni Cesaltina , Fernandes Fabiola , Rodrigo‐Calvo Maria Teresa , Diaz‐Mercedes Sherley , Ribera‐Cortada Inmaculada , Sanfeliu Esther , del Campo Ricardo López , Marimon Lorena , Alós Silvia , Vega Naiara , Pérez Francisco M. , Trias Isabel , Carrilho Carla , Ordi Jaume 
Published: October 2022

AbstractTwo pathways have been described for vulvar squamous cell carcinomas (VSCC), one associated with human papillomavirus (HPV), and the other HPV‐independent. We compared the etiopathogenic features of a series of VSCC from Mozambique, a sub‐Saharan country with high prevalence of HPV and HIV, with those of Spain, a European country with low prevalence of HPV and HIV. All VSCC diagnosed at the two institutions from January 2018 to December 2020 were included (n = 35 and n = 41, respectively). HPV DNA detection and genotyping, and immunohistochemistry for p16 and p53 were performed. Tumors showing p16 positive staining and/or HPV DNA positivity were considered HPV‐associated. 34/35 tumors (97%) from Mozambique and 8/41 (19%) from Spain were HPV‐associated (P < .001). Mean age of the patients from Mozambique and Spain was 45 ± 12 and 72 ± 14, respectively (P < .001). No differences were found in terms of HPV genotypes or multiple HPV infection rates. 1/35 tumors (3%) from Mozambique and 29/41 (70%) from Spain showed abnormal p53 immunostaining (P < .001). In contrast with the predominance of HPV‐independent VSCC affecting old women in Europe, most VSCC in sub‐Saharan Africa are HPV‐associated and arise in young women. This data may have important consequences for primary prevention of VSCC worldwide.
Characteristics and response to next‐generation sequencing‐guided therapy in locally advanced or metastatic esophageal cancer
Authors: Ma Yueyun , Li Wenjie , Chen Shiyu , Lin Shuimiao , Ding Sijie , Zhou Xiaomei , Liu Tongxin , Wang Rong , Wang Wei 
Published: October 2022

AbstractEsophageal cancer (EC) is a main cause of cancer‐related deaths. However, genomic alterations and the clinical value of next‐generation sequencing (NGS) in advanced or metastatic EC for precision therapy remain largely unclear. Herein, we performed comprehensive analyses on a cohort of 47 individuals with advanced or metastatic EC who underwent NGS between May 2017 and February 2020. Eventually, 227 mutated genes were identified in the cohort. TP53, NQO1, DPYD, GSTM1, XRCC1 and ERCC1 were the most mutated genes and associated with immune cell infiltration, autophagy and hypoxia. Patients who received NGS‐guided treatments exhibited better objective remission rate (ORR) (72.22%), disease control rate (DCR) (88.89%), overall survival (OS) (P = .0019) and progression‐free survival (PFS) (P = .0077) than those not receiving NGS‐guided therapies. The multivariate analyses further demonstrated that the NGS‐guided therapy was an independently prognostic factor (OS: hazard radio [HR] 0.31, 95% coincidence interval [CI] 0.1‐0.97, P = .04). In conclusion, we depicted a comprehensive mutational landscape of 47 patients with locally advanced or metastatic EC and illustrated the utility of NGS testing to guide clinical management in improving ORR, DCR, OS and PFS.
Systems Skills … From Here to Diversity
Authors: Harding Alan 
Published: October 2022

ABSTRACTCompetency, the ability to do things, is at the heart of how systems engineers realise successful systems. Over the years INCOSE and partners have codified what this means, initially in the INCOSE UK Competency Framework (INCOSE UK 2010) later adopted globally by INCOSE and used as the basis of the INCOSE Systems Engineering Competency Framework (INCOSE 2018) which, notably, included a new area of professional skills. This article considers competency from the perspective of Diversity, Equity, and Inclusion (referred to as DEI) using a variety of sources including the recently published INCOSE SE Vision 2035 (INCOSE 2022) and a variety of competency frameworks to offer a view of how the skills and competencies of systems engineers need to evolve in the future. Five new competencies are proposed, as are opportunities to improve the definitions of five more.
Systems Engineers – Value Added Product Owners
Authors: Nair Aswin Sukumaran 
Published: October 2022

ABSTRACTAgile Methodology requires specialized roles like Product Owners to act as the bridge between the business and the product delivery teams. This calls for specific skills such as a customer‐centric, design‐thinking mindset and a good vision of the overall system, its capabilities, and the ability to provide the right information at the right time.The primary duty of a product owner is to maintain a well‐refined, prioritized backlog of work items. Systems Engineers are enabled with the right methods and tools to perform solution architecture, design synthesis, system verification, and validation. Systems Engineers have visibility into the overall system, interfaces between sub‐systems, and external interface requirements. Enabled with the knowledge of Technical Processes, Systems Engineers are able to describe System Elements, their behavior, and interactions in the best possible detail. This allows them to ensure that functional and non‐functional backlog items are defined in unambiguous adequate detail.By applying their knowledge and expertise as mentioned above, Systems Engineers can effectively perform Product Owner duties and enables Agile teams to work efficiently to deliver the correct system increment at the end of each pre‐defined time box.
Why Mountain Bike Trails Try to Scare You Off
Authors: Wright Courtney 
Published: October 2022

ABSTRACTINCOSE Certification looks for multiple pillars of skills. Some candidates have a pillar in Systems Engineering, a pillar in other Science, Technology, Engineering, and Math (STEM) skills, and a pillar in a domain (or multiple pillars in these areas). What does that look like on an application for INCOSE Certified Systems Engineering Professional (CSEP)? How do our Certification Application Reviewers (CARs) assess it? This article goes far from the commonly discussed domains and products of systems engineering and looks at how leading a bike ride can be done better by using systems engineering principles. It concludes with whether applying Systems Engineering in such an unusual case is enough to qualify a candidate for CSEP.
Understanding the information landscape in agricultural communities in rural Bangladesh
Authors: Mazumdar Suvodeep , Ehdeed Sukaina , Jimenez Andrea , Ahmed Faisal , Momen Sifat , Rasheduzzaman Mirza 
Published: October 2022

AbstractKnowledge sharing in rural agricultural communities is vital to the success of farmers and sustaining high yields. A range of actors in the knowledge landscape participate in knowledge sharing, and with this, a variety of complexities are introduced. In this paper, we report on a set of field visits, interviews and focus groups in various settings to understand this complex nature of the knowledge landscape. Our study was set within multiple locations within 20 miles North‐East of Dhaka, the capital city of Bangladesh. Our findings highlight the high level of interconnectedness of different actors in the agricultural communities and the complexities involved in establishing trust of information. We report on the importance of fostering successful relationships within the communities and the growing strains of climate change.
The longitudinal course of childhood bullying victimization and associations with self‐injurious thoughts and behaviors in children and young people: A systematic review of the literature
Authors: Wilson Emma , Crudgington Holly , Morgan Craig , Hirsch Colette , Prina Matthew , Gayer‐Anderson Charlotte 
Published: October 2022

AbstractIntroductionBullying victimization has consistently been highlighted as a risk factor for self‐injurious thoughts and behaviors (SITBs) in young people. This systematic review of prospective, community‐based studies explored associations between bullying victimization (traditional/face‐to‐face and cyber) across the full spectrum of self‐harm and suicidality, in children and young people aged up to (and including) 25 years. Importantly, associations by sex/gender were explored.MethodsMEDLINE, Embase, PsycINFO, CINAHL and Scopus were searched for articles meeting the inclusion criteria. Articles were screened by title, abstract and full text. Quality appraisal was performed using the Newcastle‐Ottawa Scale for cohort studies. Data were synthesized narratively. The protocol is registered on PROSPERO (CRD42021261916) and followed PRISMA 2020 guidelines.ResultsA total of 35 papers were included, across 17 countries. Results were presented by bullying type: traditional/face‐to‐face (n = 25), cyber (n = 7) and/or an aggregate of both types (n = 7). Outcomes included suicidal ideation (n = 17), self‐harm (n = 10), suicide attempt (n = 4), NSSI (n = 4), other (n = 7). Studies measured outcomes in under 18s (n = 24), 18–25‐year‐olds (n = 8) and both under 18s and 18–25‐year‐olds (n = 3). Studies exploring the role of sex/gender (20%) found some interesting nuances.ConclusionsSome weak to strong associations between bullying and SITBs were found yet conclusions are tentative due to study heterogeneity (e.g., methods used, conceptualizations and operationalisations of exposures/outcomes). Future research should address methodological issues raised in this review, and further explore gender differences in bullying, including by bullying sub‐types (e.g., overt or relational) and victim status (e.g., victim or bully‐victim).
Click chemistry functionalization of self‐assembling peptide hydrogels
Authors: Sharick Joe T. , Atieh Angelina J. , Gooch Keith J. , Leight Jennifer L. 
Published: October 2022

AbstractSelf‐assembling peptide (SAP) hydrogels provide a fibrous microenvironment to cells while also giving users control of biochemical and mechanical cues. Previously, biochemical cues were introduced by physically mixing them with SAPs prior to hydrogel assembly, or by incorporating them into the SAP sequence during peptide synthesis, which limited flexibility and increased costs. To circumvent these limitations, we developed “Click SAPs,” a novel formulation that can be easily functionalized via click chemistry thiol‐ene reaction. Due to its high cytocompatibility, the thiol‐ene click reaction is currently used to crosslink and functionalize other types of polymeric hydrogels. In this study, we developed a click chemistry compatible SAP platform by addition of a modified lysine (lysine‐alloc) to the SAP sequence, enabling effective coupling of thiol‐containing molecules to the SAP hydrogel network. We demonstrate the flexibility of this approach by incorporating a fluorescent dye, a cellular adhesion peptide, and a matrix metalloproteinase‐sensitive biosensor using the thiol‐ene reaction in 3D Click SAPs. Using atomic force microscopy, we demonstrate that Click SAPs retain the ability to self‐assemble into fibers, similar to previous systems. Additionally, a range of physiologically relevant stiffnesses can be achieved by adjusting SAP concentration. Encapsulated cells maintain high viability in Click SAPs and can interact with adhesion peptides and a matrix metalloproteinase biosensor, demonstrating that incorporated molecules retain their biological activity. The Click SAP platform supports easier functionalization with a wider array of bioactive molecules and enables new investigations with temporal and spatial control of the cellular microenvironment.
Biomimetic engineered approaches for neural tissue engineering: Spinal cord injury
Authors: Pourkhodadad Soheila , Hosseinkazemi Hessam , Bonakdar Shahin , Nekounam Houra 
Published: October 2022

AbstractThe healing process for spinal cord injuries is complex and presents many challenges. Current advances in nerve regeneration are based on promising tissue engineering techniques, However, the chances of success depend on better mimicking the extracellular matrix (ECM) of neural tissue and better supporting neurons in a three‐dimensional environment. The ECM provides excellent biological conditions, including desirable morphological features, electrical conductivity, and chemical compositions for neuron attachment, proliferation and function. This review outlines the rationale for developing a construct for neuron regrowth in spinal cord injury using appropriate biomaterials and scaffolding techniques.
Peripheral blood stem cells collection by apheresis in very low‐weight children with malignant diseases—A single center experience
Authors: Vieira Lúcia , Teixeira Sofia , Reis Conceição , Salselas Ana , Bordalo Filipa , Lopes Sérgio , Pinho Catarina , Amado Fátima , Roncon Susana 
Published: October 2022

AbstractBackgroundHematopoietic stem cell transplantation is used in the treatment of children with malignant and non‐malignant diseases. However, apheresis of peripheral blood stem cells (PBSC) represents a challenge in children below 10 kg.MethodsA retrospective trial was conducted in the Cellular Therapy Department of Portuguese Oncology Institute of Porto. Inclusion criteria: children with body weight inferior to 10 kg who underwent autologous PBSC apheresis until 2021. Demographic and clinical data were collected and our institutional protocol was described. COBE Spectra apheresis system (TerumoBCT, Lakewood, Colorado) until 2012 and then Spectra Optia (TerumoBCT) were used.ResultsSixteen leukocytaphereses were performed in 13 patients—nine females (69%). Mean age and weight were 13.31 months (±5.26) and 8.31 kg (±1.17), respectively. The initial CD34+ cells/μL in peripheral blood was 70.8 (±61.9). A central venous catheter (CVC) was exclusively used in all but one patient, in whom a peripheral vein was also required. In 10 procedures, both heparin and anticoagulant citrate dextrose solution—formula A (ACD‐A) were used; in the remaining ones, only ACD‐A was employed. The median duration of each procedure was 168 minutes (±45) and 2.96 blood volumes (±0.31) were processed. Median CD34+ cells yield per leukocytapheresis was 6.52 × 106/kg (±9.87 × 106). CD34+ cell extraction rates were not significantly different between the two apheresis systems. Platelet and magnesium levels were significantly lower after collection (P < .001 and P = .009, respectively).ConclusionsAlthough recommendations are lacking, we have successfully and safely performed leukocytaphereses in children with body weight below 10 kg. The authors believe that a permanent and dynamic comprehensive evaluation of each child is paramount for attaining good results.
Contaminating transfection complexes can masquerade as small extracellular vesicles and impair their delivery of RNA
Authors: McCann Jenna , Sosa‐Miranda Carmen Daniela , Guo Huishan , Reshke Ryan , Savard Alexandre , Zardini Buzatto Adriana , Taylor James A. , Li Liang , Gibbings Derrick J. 
Published: October 2022

AbstractOne of the functions of small extracellular vesicles (sEVs) which has received the most attention is their capacity to deliver RNA into the cytoplasm of target cells. These studies have often been performed by transfecting RNAs into sEV‐producing cells, to later purify and study sEV delivery of RNA. Transfection complexes and other delivery vehicles accumulate in late endosomes where sEV are formed and over 50% of transfection complexes or delivery vehicles administered to cells are released again to the extracellular space by exocytosis. This raises the possibility that transfection complexes could alter sEVs and contaminate sEV preparations. We found that widely used transfection reagents including RNAiMax and INTERFERin accumulated in late endosomes. These transfection complexes had a size similar to sEV and were purified by ultracentrifugation like sEV. Focusing on the lipid‐based transfection reagent RNAiMax, we found that preparations of sEV from transfected cells contained lipids from transfection complexes and transfected siRNA was predominantly in particles with the density of transfection complexes, rather than sEV. This suggests that transfection complexes, such as lipid‐based RNAiMax, may frequently contaminate sEV preparations and could account for some reports of sEV‐mediated delivery of nucleic acids. Transfection of cells also impaired the capacity of sEVs to deliver stably‐expressed siRNAs, suggesting that transfection of cells may alter sEVs and prevent the study of their endogenous capacity to deliver RNA to target cells.
Mulberry leaf extract improves intestinal barrier function and displays beneficial effects on colonic microbiota and microbial metabolism in weaned piglets
Authors: Song Min , Wang Chaopu , Yu Miao , Deng Dun , Liu Zhichang , Cui Yiyang , Tian Zhimei , Rong Ting , Li Zhenming , Ma Xianyong , Ti Junling 
Published: October 2022

AbstractBACKGROUNDMulberry leaf extract (MLE) extracted from mulberry leaves is rich in a variety of bioactive ingredients and can be used as feed additives of weaned piglets. The present study was conducted to evaluate the effects of dietary MLE supplementation on intestinal barrier function, colon microbial numbers and microbial metabolites of weaned piglets.RESULTSMLE supplementation increased the villus height and the villus height/crypt depth ratio in jejunum and ileum (P < 0.05), increased the mRNA expression of ZO‐1, Claudin‐1 and MUC‐2 in the ileal mucosa (P < 0.05), and decreased the serum level of lipopolysaccharide (P < 0.01). Meanwhile, MLE reduced the mRNA expression of tumor necrosis factor‐α and interleukin‐1β (P < 0.05) and increased secretory immunoglobulin A level in the ileal mucosa (P < 0.05). In addition, MLE increased the numbers of beneficial bacteria Bifidobacterium and Lactobacillus (P < 0.05) and decreased the number of potential pathogenic bacteria Escherichia coli (P < 0.05) in the colon. Correspondingly, MLE supplementation reduced the pH value of colonic digesta (P < 0.05) and altered the microbial fermentation pattern of the colon by increasing the concentrations of microbial metabolites derived from carbohydrates fermentation such as lactate, acetate, butyrate and total short‐chain fatty acids (P < 0.05), and decreasing the concentrations of microbial metabolites derived from amino acid fermentation such as p‐cresol, skatole, spermine, histamine and tryptamine (P < 0.05).CONCLUSIONMLE supplementation improved intestinal barrier function and displayed beneficial effects on colon microbes and microbial metabolism in weaned piglets. © 2022 Society of Chemical Industry.
Anthropomorphizing religious advertising: The moderating role of political ideology
Authors: van Esch Patrick , Cui Yuanyuan (Gina) , Arli Denni , Hutchins Jennifer 
Published: October 2022

AbstractWe examine the anthropomorphism of brands as either a servant or a partner in religious advertising. Across five studies, we demonstrate that the impact of such anthropomorphism depends on consumers' political ideology. When exposed to religious advertisements (vs. nonreligious advertisements; Studies 1B and 1C), politically conservative consumers are more favorable toward brand‐as‐a‐servant anthropomorphism (Study 1), which arises from greater state‐based compassion (Study 2). However, this conditional preference for servant anthropomorphism only occurs for less religious consumers (Study 3). This study informs marketers regarding optimizing the effectiveness of using anthropomorphic brand images in religious advertising predicated on political ideology‐based segmentation strategies. The key takeaway is that portraying a brand as a servant is more appealing for conservative consumers who are less religious.
Critical thinking abilities among newly graduated nurses: A cross‐sectional survey study in China
Authors: Sun Yongfang , Yin Yuhuan , Wang Jiancheng , Ding Zhaohong , Wang Dongping , Zhang Yiyin , Zhang Juxia , Wang Yuan 
Published: October 2022

AbstractAimThe aim of this study is to describe critical thinking dispositions among newly graduated nurses with different educational background in China and to explore related factors.DesignA cross‐sectional questionnaire survey.MethodsThe data were collected using the Chinese Version of Critical Thinking Dispositions Inventory (CTDI‐CV). Overall, 588 newly graduated nurses finally completed the survey. Spearman and Pearson's correlation coefficients were used to examine the correlation between the CDTI‐CV and nurses' general characteristics.ResultsIn terms of open‐mindedness, analysis and inquisitiveness subscales, significant differences were found among nurses based on three educational level. When dichotomizing total CTDI scores into high and low, nearly 80% of the respondents fell into low score group. Pressure from workplace was high for 68.4% of them. Significant correlation was found among the new graduated nurses' critical thinking ability and their age, education level, reading habit and attitude towards nursing profession.
A quantitative, multicentre, longitudinal study of patient experiences after gynaecological day surgery
Authors: Gran Bruun Anne‐Marie , Svensen Katrine , Johansen Elin , Halstensen Thor‐David , Gustavsson Anette , Leonardsen Ann‐Chatrin Linqvist 
Published: October 2022

AbstractAimThe aim of this study was to explore patients' experiences after gynaecological day surgery one and 30 days postoperatively, as well as potential factors influencing these experiences.DesignThe study had a multicentre, quantitative, longitudinal design.MethodsThe study was conducted in three different hospitals' day surgical unit and included patients undergoing gynaecological surgery in general anaesthesia. We used a questionnaire including the European Quality of Life tool (EQ5D3L), the Quality‐of‐Recovery‐15 questionnaire (QoR‐15) and items relating to patient experiences, the first day (T1, n = 444) and 30 days (T2, n = 193) after surgery. Data were collected in the period March 2019 to March 2020.ResultsResults show that patients mainly had positive experiences and ranged quality of recovery high, even though some areas needed improvement. Patient scores on the QoR‐15 relating to their experiences 24 h postoperative were rated higher at T1 than at T2. Twenty per cent of the respondents experienced complications such as infection, haemorrhage and pain. About 1/5 of these contacted healthcare services, and three per cent was hospitalized. EQ5D score was the only factor that made an statistically significant impact on patients' experiences with quality of recovery (R2 .169, F = 82.87). However, this effect was weak.