bluuebunny/crossref_metadata_2025_split huggingface dataset:
PENGARUH BIMBINGAN KEAGAMAAN DAN FASILITAS AGAMA TERHADAP KETAATAN BERIBADAH PADA SISWA DI SMP ISLAM SUDIRMAN BANYUBIRU KAB. SEMARANG TAHUN 2022
Authors: Umami Arizkha 
Published: October 2022

Penelitian ini bertujuan untuk mengetahui pengaruh Bimbingan Keagamaan dan Fasilitas Agama terhadap Ketaatan Beribadah pada Siswa di SMP Islam Sudirman Banyubiru Kab. Semarang Tahun 2022. Penelitian ini menggunakan metode kuantitatif dengan olah data primer melalui penyebaran kuesioner terhadap siswa di SMP Islam Sudirman Banyubiru Kab. Semarang. Sampel yang diambil sebanyak 30 responden dengan teknik random sampling. Kemudian data yang diperoleh diolah dengan program komputer SPSS Statistics. Analisis yang digunakan meliputi uji instrumen, uji asumsi klasik, dan uji hipotesis. Berdasarkan pengujian, memperoleh hasil: bimbingan keagamaan berpengaruh positif dan signifikan terhadap ketaatan beribadah, fasilitas agama berpengaruh positif dan signifikan terhadap ketaatan beribadah, serta bimbingan keagamaan dan fasilitas agama secara bersama-sama berpengaruh positif dan signifikan terhadap ketaatan beribadah.
OPTIMIZATION OF CUTTING MODES ON HEAVY MACHINES
Authors: Klymenko Galyna , Kovalev Viktor , Vasylchenko Yana , Shapovalov Maksym , Sherbakova Anastasiya 
Published: October 2022

The optimization of the cutting process is of great importance for metalworking in ensuring the high quality of products and increasing its competitiveness. Increasing the efficiency of metalworking is based on the designation of optimal cutting parameters. It is determined that the economic criterion is the criterion of optimality: discounted costs, prime cost and productivity. The objective functional of the discounted costs and productivity which considers feature of cutting on heavy machines is generated. The limitations of the design of the machine and tool, work material and tool material, tool life, as well as the limitations caused by the quality of the tool operation is taken into account. Optimization of cutting modes is carried out simultaneously by two variables - feed S and cutting speed V. Optimal cutting modes should provide the maximum average productivity and minimum average cost. If several optimality criteria are used, optimization is performed for each of them. The final decision is made by comparing the obtained values. The average actual tool life is a random value. It was accepted that the durability period of carbide tools on heavy machine tools was distributed according to the Weibull law. It is established that the cutting process is characterized by a large number of interrelated factors influencing both the course and the result of the process. With increased requirements to the stability of the technological process of machining of parts, in determining the rational cutting parameters, the tool reliability is also taken into account
Investigation of Teacher Candidates' Nature of Science Beliefs In Terms of Gender, Program, and Class Level
Authors: Çetin Ali , Kahyaoğlu Mustafa 
Published: October 2022

This research aims to examine teacher candidates' nature of science beliefs in terms of certain variables (gender, program, and class level). The participants of the research are 364 teacher candidates studying at the faculty of education of a public university in three programs; science education, elementary mathematics education, computer education, and instructional technology. Convenience sampling was applied and a relational screening model from descriptive research design was used. "Nature of Science Beliefs Scale" developed by Özcan and Turgut (2014) was used as a data collection tool. Subsequently, data analysis was conducted through SPSS statistical software by applying independent samples t-test and one-way ANOVA analysis. According to the results of the study, teacher candidates' nature of science beliefs was found on the undecided level. Additionally, female teacher candidates have a higher level than male teacher candidates related to the nature of science beliefs dimensions of tentativeness, observation and inference, scientific method/methods, assumptions and boundaries, socio-cultural embeddedness, and theories and laws, and it was found that this difference was statistically significant. In terms of program variables, only a difference was found in the dimension of scientific method/methods in favor of science teacher candidates. Finally, there was a statistically significant difference in the dimensions of tentativeness and theories and laws in terms of a class-level variable. Consequently, new activities and subjects that can be added to the curriculum are recommended
RETRACTED: Evaluatıon of the Flıpped Learnıng Model: A Case Study
Authors: Özdoğru Mehmet 
Published: October 2022

RETRACTED:
Following a rigorous, carefully concerns, and considered review of the article published in Dinamika Ilmu, Vol. 22(1), June 2022 to the article entitled “Evaluatıon of the Flıpped Learnıng Model: A Case Study ".
There was a problem with the project owners because the data of the article was taken from a project and it has been retracted from Dinamika Ilmu.
The document and its content have been removed from Dinamika Ilmu and reasonable effort should be made to remove all references to this article.
Islamic Legal Status on Hajj for Transgender People according to Muslim Scholars in North Sulawesi
Authors: Yusuf Nasruddin , Willya Evra , Rajafi Ahmad , Djabli Irfan 
Published: October 2022

Abstract
This study investigates the perceptions of scholars concerning transgender people's legal status on their Hajj ritual validity. In North Sulawesi, seven scholars are considered the opinion-makers and authorities following their understanding of Hajj ritual procedures in Islamic law. The data were analyzed using qualitative methods through interviews and the needs theory by al-Shāṭibī, Ibn Khaldun, and Maslow. The results showed that the gender status of those yet to transition remains original. In contrast, the transitioned transgenders’ status should change to the original law following the court's decision. Second, the scholars approved Hajj rituals for those yet to transition because they had their actual gender and sex. Furthermore, Hajj rituals for transgenders were also legally acceptable in Islamic law following the new status exception by the court. The transgenders' Hajj rituals are valid based on their initial gender or the court's decision. The hajj practices are invalid for those who illegally transition or without court approval.
Keywords: Hajj conception, Hajj rituals, transgender people, Ulama in North Sulawesi, Manado.
The Polemic of Pig Kidney Xenotransplantation for Human Life Sustainability:
Authors: Dzukroni Arisy Abror 
Published: October 2022

End-stage renal disease (ESRD) cases continue to increase. However, the increase in cases of ESRD is not matched by the supply of kidneys as a condition for being able to perform a kidney transplant. Although this is not the only way to treat this case, it is only with a kidney transplant that the patient can truly recover. New York University Langone's success in xenotransplantation procedure using a genetically engineered pig kidney has become a new polemic in Islamic law issues. According to Islamic law, a pig has forbidden legal status (haram). This article analyzes the practice of xenotransplantation of pig kidneys in the human body using the concept of “Halal-haram” by Yusuf al-Qaradawi and “Maslahah” by Harun Sencal & Mehmet Asutay. This study is a qualitative method using a library research approach. This study found that it is permissible to do prohibited things during an emergency (daruriyat). In addition, in the realm of maslahah, hajiyat cannot beat daruriyat. Finally, summing up from these two Islamic scholars’ thoughts indicates that pig kidney xenotransplantation is prohibited as long as other alternatives to treat ERSD patients are available. Some options might be taken, such as hemodialysis and blood filtration (CAPD); therefore, it cannot be considered an emergency.
Keywords: Pig kidney xenotransplantation, Islamic legal thoughts, halal-haram concept, principle of mashlahah
G-CSF-mobilized Peripheral Blood Mononuclear Cells Combined with Platelet-rich Plasma Restored the Ovarian Function of aged rats via angiogenesis and glycolysis modulation
Authors: Yuan Lifang , Huang Weiyu , Bi Yin , Qin Saiqiong , Wang Xi , Li Ting , Wei Peiru , Du Jiebing , Zhao Ling , Liu Bo , Yang Yihua 
Published: October 2022

Abstract
Background
Regenerative medicine with peripheral blood mononuclear cells (PBMCs) transplantation sheds light on the issue of premature ovarian insufficiency (POI). However, the efficiency of PBMCs treatment in patients with natural ovarian aging (NOA) remain unclear.
Methods
13-month-old female Sprague–Dawley (SD) rats were used to verify NOA model. Seventy-two NOA rats were randomly divided into three groups: the NOA control group, PBMCs group, and PBMCs + PRP group. PBMCs and PRP were transplanted by intraovarian injection. The effects of ovarian function and fertility ability were measured after transplantation.
Results
Transplantation of PBMCs could restoration of the normal estrus cycle, consistent with recovery of serum sex hormone levels, increased follicle numbers at all stages, and restoration of fertility by facilitating pregnancy and live birth. Moreover, when combined with PRP injection, these effects were more significant. The male-specific SRY gene was detected in the ovary at all four time points, suggesting PBMCs continuously survived and functioned in NOA rats. In addition, after PBMCs treatment, the expression of the angiogenesis-related and glycolysis-related markers in ovarian were upregulated, which indicated that these effects were associated with angiogenesis and glycolysis.
Conclusions
PBMCs transplantation restore the ovarian functions and fertility of NOA rats by increasing ovarian vascularization, folliculogenesis and glycolysis, and PRP could enhance the efficiency.
Development and validation of a multiparametric semi-quantitative scoring system for the histopathological assessment of ischaemia severity in skeletal muscle.
Authors: Sanz-Nogués Clara , Creane Michael , Hynes Sean O. , Chen Xizhe , O’Brien Timothy 
Published: October 2022

Abstract
Skeletal muscle is one of the most abundant and dynamic tissues of the body, with a strong regenerative capacity. Muscle injuries can occur as a result of a variety of events, including tissue ischaemia. Lower limb ischaemia occurs when there is an insufficient nutrient and oxygen supply, often caused by stenosis of the arteries due to atherosclerosis. The aim of this study was to develop and validate a multiparametric scoring tool for assessing ischaemia severity in skeletal muscle in a commonly used pre-clinical animal model. Tissue ischaemia was surgically induced in mice by ligation and excision of the femoral artery. Calf muscles were carefully dissected, prepared for histological analysis and scored for inflammation, fibrosis, necrosis, adipocyte infiltration and muscle fibre degeneration/regeneration. Kendall’s coefficient of concordance (W) showed a very good agreement between the appraisers when scoring each individual histological feature: inflammation (W = 0.92 p-value 0.000), fibrosis (W = 0.94 p-value 0.000), necrosis (W = 0.77 p-value 0.000), adipocyte infiltration (W = 0.91 p-value 0.000) and fibre degeneration/regeneration (W = 0.86 p-value 0.000). Intra-rater agreement was also excellent (W = 0.94 or more, p-value 0.000). There was a statistically significant negative direct association between the level of muscle ischaemia damage and the calf muscle weight. Here, we have developed and validated a new multiparametric, semi-quantitative scoring system for assessing skeletal muscle damage due to ischaemia, with excellent inter- and intra-rater reproducibility. This scoring system can be used for assessing treatment efficacy in pre-clinical models of hindlimb ischaemia.
Investigating Socio-economic Factors Affecting the Health Expendiures of Households in East Azarbayjan Province - the Heckman Regression Model
Authors: Rasoulpour Yousef , Moeeni Maryam , Mahboub-Ahari Alireza 
Published: October 2022

Abstract
Introduction: Direct payments for health services are one of the types of household expenses, whose socio-economic conditions, as well as government policies in the field of health, including medical insurance, are effective factors in determining its amount. Therefore, the analysis of factors affecting direct payments is one of the basic issues in health sector financing policies. Therefore, the present study was conducted with the aim of investigating the socio-economic factors influencing the health expenditures of households living in East Azerbaijan province in 2017 and using the Heckman regression model.
Material and Methods: A cross-sectional descriptive study was conducted on 3000 households during June and July 2017 in the form of provincial health accounts. A stratified multi-stage sampling method was used to select the sample. The tool for collecting data was the household income-expenditure questionnaire, which had been prepared and used by Iranian Statistics. Data on socio-economic and demographic characteristics were collected and analyzed using Stata 14 software.
Results: The results of the descriptive findings showed that the most type of insurance among the people studied was social security insurance (40% of households) and the least was insurance of the relief committee (less than 1% of households). About 400 households (12% of households) lack basic insurance. Out of the total population participating in this study, 34% of households had supplementary insurance. Also, based on the inferential findings of socio-economic factors such as having health insurance, not having supplementary insurance, the age of the head of the household, university education, the head of the household being married, the size of the household and the presence of a child seven or under seven years old in the household lead to an increase in household health expenses. became Female-headed households had lower health expenditures.
Conclusion: Considering the existence of a positive and significant relationship between the consumption of health services (outpatient and inpatient services) and the direct payment of households for the aforementioned services, it is suggested to measure the indicators related to the financial participation of households in health in all the provinces of the country on a regular and annual basis. and in this way, the impact of each program in the field of health in terms of reducing people's share of health costs and increasing justice in fair financial participation in health can be measured.
Revealing the clinical impact of MTOR and ARID2 gene mutations on MALT lymphoma of the alimentary canal using targeted sequencing
Authors: Huang Xiang , Li Yao , Luo Shuai , Wang Jinjing 
Published: October 2022

Abstract
Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) are a group of diseases with marked heterogeneity, including clinical, immunohistochemical, and molecular heterogeneity. The disease remains unspecified in the genetic landscape with only a few sequencing studies to date; however, systematic studies of alimentary canal MALT lymphoma have not been reported. To better understand the genetics of this tumor, targeted sequencing in a group of 31 cases (including 2 esophageal, 2 colonic, 4 small intestinal, and 23 gastric cases) were performed. We found epigenetic regulation (DNMT3A, KMT2D, KMT2A, EP300, TET2, etc.), signaling pathways (APC, CHD8, TNFAIP3, TNFRSF14, ZAP70, NF1,), and tumor suppressor genes (TP53, BCORL1, FOXO1, ATM, etc.) involved. Moreover, we found MTOR gene mutations in 16% of the cases that made these patients more prone to recurrence and metastasis than those with MTOR wild type genes. More interestingly, ARID2 mutations were detected in 32% of all the cases, and the mutation rate was higher and statistically significant in Helicobacter pylori (Hp)-negative patients in the gastric group. Therefore, this study found that MTOR and ARID2 gene mutations have pathogenic and prognostic implications.
Endorsing improvements of AFP and Measles Surveillance Performances after the first COVID 19 pandemic lockdown (2020-2021), a comparative analysis study design: the case of Sidama Province, Ethiopia
Authors: Denegetu Amenu Wesen , Asemahaegn Eshetu Wassie , Birru Tadesse Gossaye 
Published: October 2022

Abstract
Introduction
Following the declaration of COVID-19 as a global public health threat, disease surveillance activities were crippled in 2020. Documenting surveillance improvements of Sidama province in 2021 has to be endorsed to boost the performances.
Methods
A comparative analysis study design of acute flaccid paralysis and measles surveillance data of 2020 and 2021 for Sidama province was used. The non-polio AFP rate and stool adequacy rate were used to assess the sensitivity of the AFP surveillance. Whereas, the non-measles febrile rash rate was used to assess the measles surveillance.
Results
A total of 91 AFP cases in 2021 and 44 in 2020 have been detected and investigated for polio analysis. All cases were discarded in both years. The stool adequacy rate for 2021 was 90.1%; whereas, 86.4% in 2020. Annualized non-polio AFP rate was 2.2/100,000 for 2020 and 3.8/100,000 for 2021, which the latter is much higher to the minimum expected rate in outbreak areas of 3/100,000.
A total of 154 suspected measles cases in 2021 and 111 in 2020 have been investigated for IGM analysis. In 2020, 64 and 11 in 2021 IGM positive for measles were identified. The non-measles febrile rash rate for 2020 was 1.1/100,000; whereas, 2.5/100,000 for 2021.
Conclusion
There is an improved in the sensitivity of AFP and measles surveillance performance for Sidama province in 2021. Sustaining high quality measles and AFP surveillance is suggested to maintain measles and polio free statuses.
Characterization and treatment of gemcitabine- and cisplatin-resistant bladder cancer cells with a Pan-RAS inhibitor
Authors: Yoshino Hirofumi , Yokoyama Seiya , Tamai Motoki , Okamura Shunsuke , Iizasa Sayaka , Sakaguchi Takashi , Osako Yoichi , Inoguchi Satoru , Matsushita Ryosuke , Yamada Yasutoshi , Nakagawa Masayuki , Tatarano Shuichi , Tanimoto Akihide , Enokida Hideki 
Published: October 2022

Abstract
Background
Combination chemotherapy with gemcitabine and cisplatin (GC) is recommended as the primary treatment for advanced bladder cancer (BC). However, the benefits of this approach are limited owing to the acquisition of drug resistance. Therefore, we characterized GC resistance in BCs and evaluated the effects of a pan-RAS inhibitor on these cells.
Methods
We examined cross-resistance between gemcitabine-resistant and cisplatin-resistant BCs. To overcome drug resistance, we used the newly developed pan-RAS inhibitor Compound 3144 in vitro and investigated genes and pathways.
Results
The half-maximal inhibitory concentration (IC50) of cisplatin in gemcitabine-resistant BCs was the same as that in parental cells, and the IC50 of gemcitabine in cisplatin-resistant BCs was also the same as that in parental cells. Furthermore, different mRNA patterns were observed between gemcitabine- and cisplatin-resistant BCs using RNA sequence analysis. Compound 3144 inhibited cell viabilities through suppression of RAS-Dependent Signaling in gemcitabine- and cisplatin-resistant BCs. RNA sequencing revealed that several genes and pathways, particularly those related to the cell cycle, were significantly downregulated in Compound 3144-treated BCs.
Conclusion
Cross-resistance was not observed, and the pan-RAS inhibitor exhibited antitumor effects in gemcitabine- and cisplatin-resistant BCs. These findings provide insights into potential therapeutic strategies for treating BC.
Development and Psychometric Evaluation of the Hope in Medicine Scale
Authors: Balthasar Lea , Bräscher Anne-Kathrin , Kaptchuk Ted Jack , Ballou Sarah Katherine , Kube Tobias 
Published: October 2022

Abstract
Background: Hope is an integral part of seeking medical treatment. However, there is a lack of measurements that allow to examine the influence of hope on treatment success and the course of symptoms. Therefore, the present study aimed to fill this gap by developing a new self-report scale, the Hope in Medicine (HIM) scale, considering hope as multi-dimensional construct.
Methods: We examined the psychometric properties of the HIM scale in a sample of 74 allergic rhinitis patients participating in a 2-week randomized-controlled trial comparing open-label placebos (OLP) with treatment as usual (TAU).
Results: The 15-item HIM scale had a Cronbach’s α of .78 and an exploratory factor analysis revealed four factors: realistic hope (i.e., hoping for specific positive outcomes such as improvement in symptoms), transcendent hope (i.e., non-directed hoping that things will turn out positively), utopian hope (i.e., hoping to contribute to greater knowledge), and technoscience hope (i.e., hoping for scientific breakthrough). Speaking to the convergent validity of the scale, hope was moderately related to treatment expectancies (r = .56) and trait optimism (r = .34). We found that high hopes were related to less symptom improvement in TAU.
Conclusions: The HIM scale showed good internal consistency and convergent validity; hence, the HIM scale might be a promising approach to investigate hope in relation to treatment success and symptom course more deeply in future studies. The negative association between hope and symptom improvement raises questions about possible downsides of hope in that context.
The immune-related gene-based prognostic index predicts the prognosis and effect of immune checkpoint inhibitors in hepatocellular carcinoma
Authors: Qu Jialin , Sun Fenghao , Guan Hui , Hou Yichen , Qi Haoran , Sun Xiaorong , Xing Ligang 
Published: October 2022

Abstract
Background: Immune-related genes have been confirmed to be related to tumor development and anti-tumor immune response. Therefore, immune-related genes are potential candidate for predicting prognosis and immunotherapy response. We aimed to explore the relationship between immune-related genes and the prognosis, tumor microenvironment and response to immunotherapy in HCC.
Methods: The immune-related gene-based prognostic index (IRGPI) is constructed by 4 hub genes that are most closely related to prognosis among 1.811 immune related genes. We then sequentially compared the differences in clinical characteristics, driver gene mutations, immune microenvironment and immunotherapy between the two groups of IRGPI. Finally, multiplex immunofluorescence staining was used to assess the abundance of infiltrating CD8+ T cells in tumor microenvironment between different subgroups.
Results: IRGPI-high significantly related to higher disease progression and shorter survival time. IRGPI is accompanied by a higher TMB and frequency of driver gene mutations that predicts worse prognosis. In tumor microenvironment, the number and activity of tumor-infiltrating immune cells in the IRGPI-low group was significantly greater than that of the IRGPI-high. TIDE and three immunotherapy datasets showed that patients in the IRGPI-low group are more in an immune dysfunction state and respond well to ICIs. Immunostaining on the HCC cohort further confirmed that CD8+ T cells were more abundant in IRGPI-low group, while the tumor microenvironment of IRGPI-high group presents a scene of immune desert, which corresponds to our results and partly explains why IRGPI-high group cannot respond well to ICIs.
Conclusions: IRGPI was created based on the immune-related genes in HCC. The novel prognostic model can predict prognosis and response to ICIs in HCC patients.