bluuebunny/crossref_metadata_2025_split huggingface dataset:
Trajectory detection of quadrotor UAVs based on parameter prediction and anti-disturbance
Authors: Li Dongfang , Wang Chao , Deng Hong-bin 
Published: July 2022

Abstract
In order to improve the trajectory detection accuracy of highly coupled and nonlinear quadrotor UAVs, a trajectory detection method of UAVs based on parameter prediction and anti-disturbance is developed. This method establishes the mechanical model of UAVs with external disturbance. By predicting the uncertain state parameters of the system, the flight state can be compensated and chattering of the airframe in flight can be eliminated. By designing the predicted value update law of time-varying external disturbances, the attitude control input and position control input of the system are compensated, the negative impact of disturbances such as airflow, wind resistance and actuator failure on UAV trajectory detection is reduced, and the adaptability and anti-disturbance ability of the UAV to the environment are improved. Besides, the stability of the attitude and position subsystem of the UAV are verified by the Lyapunov method. Rigorous theoretical analysis and extensive simulation research show that this method can make the quadrotor UAV have good trajectory detection accuracy and stability.
Effect of chemotherapy on gray matter and brain activation in breast cancer patients: an activation likelihood estimation meta-analysis
Authors: Huang Bin , Lyu Cui , Yu Jing , Du Xia , Yin Yi , Huang Mingming , Gao Bo , Chen Bihong T 
Published: July 2022

Abstract
Purpose Utilizing activation likelihood estimation (ALE) meta-analysis to investigate alterations of gray matter (GM) and brain activations in patients with breast cancer treated with chemotherapy. Methods Systematic literature search was performed to identify relevant reports. ALE method was used to assess pooled neuroimaging data obtained from selected reports for both GM alteration via voxel-based morphometry (VBM) analysis and brain activation changes from task-based functional MRI (fMRI). Results There were 9 GM studies and 14 fMRI studies included in this meta-analysis. In ALE analysis of GM studies, GM reduction was noted in right superior frontal gyrus, right declive, right insula, right supramarginal gyrus, right culmen, etc. GM increase was noted in left cingulate gyrus, left lentiform nucleus, right cingulate gyrus, right caudate, left superior frontal gyrus, etc. In ALE analysis of fMRI, hyperactivation clusters included regions in left thalamus, left claustrum, left lentiform nucleus, left inferior frontal gyrus, right inferior frontal gyrus, etc. Hypo-activation clusters included regions in left cingulate gyrus, left precuneus, right fusiform gyrus, left middle temporal gyrus, left cuneus, etc. Conjunction analyses showed only overlapping area with both GM reduction and brain hyperactivation was located in inferior parietal lobule. Conclusion This study identified alterations of GM and task-based brain activation in breast cancer patients treated with chemotherapy. This study contributed to the literature on chemotherapy associated neural correlates of brain changes in breast cancer patients.
Conservative Surgical Approach towards Placenta Accreta Spectrum Disorders for Uterine Preservation
Authors: Siraj Shahul Hameed Mohamed , TAN Kok Hian , Wright Ann 
Published: July 2022

Abstract
Objective
We previously described a technique for repair of the myometrial defect at repeat Caesarean section which increases residual myometrial thickness thereby potentially reducing future niche-related complications. Here we describe how this technique can be modified for use for placenta accreta spectrum disorders which is supported by emerging evidence that this is more a disorder of myometrial deficiency than morbid adherence
Design:
The surgical performance of peripartum hysterectomy was compared with that of the modified technique in all women having repeat Caesarean delivery for placenta accrete spectrum disorder in a tertiary unit in Singapore between December 2019 and October 2021.
Methods
Modification of the original technique involved the systematic delivery of the placenta starting from its most posterior attachment after uterine exteriorisation, followed by the identification, mobilization and apposition of the boundaries of myometrial defects as described previously.
Results
Ten women had Caesarean hysterectomy and ten had Caesarean section using the modified approach. Age and gestational age at delivery were similar for the two groups. Women in the modified technique group had had fewer prior Caesarean sections and had a lower body mass index. Operating time, estimated blood loss and need for transfusion were all lower in the myometrial repair group but without statistical significance and there were no visceral injuries. There was one bladder injury in the hysterectomy group.
Conclusion
The modified approach provides an effective alternative to peripartum hysterectomy with favourable surgical profile and allows uterine conservation with restoration of myometrial thickness.
Cost-effectiveness analysis of tuberculosis detection strategy based on close contact cohort
Authors: Bao Liangliang , Razbek Jaina , Zhang Yan , Xu Wanting , Mao Hongkai , Cao Mingqin , Zhang Xiaoxu , Daken Mayisha , Xia Wenjun 
Published: July 2022

Abstract
Background Close contacts of active pulmonary tuberculosis patients are high-risk groups for tuberculosis. Through active screening of contacts, more contacts who have recently been exposed to pulmonary tuberculosis patients, early existing pulmonary tuberculosis patients, and latent infections can be found. Methods The decision tree Markov model of close contacts screening strategy was established to simulate the cohort of close contacts of tuberculosis. The cost effects of passive screening strategy and active screening once, twice, and once a year were compared. Single-factor and probability sensitivity analyses were conducted to test the impact of assumptions and parameter estimates in the model on cost-effectiveness analysis. Results Compared with passive screening, active screening once, twice, and once a year could reduce the incidence of latent infection by 0.21%, 14.286%, and 63.48%, respectively; Compared with the passive screening strategy, active screening once, twice, and once a year can reduce the incidence of active tuberculosis by 4.13%, 11.22%, and 50.04% respectively; Compared with the passive screening strategy, the active screening once, twice and once a year strategy reduced the incidence of TB deaths by 2.86%, 5.71%, and 11.43% respectively. Compared with the passive screening strategy, active screening once, active screening twice, and active screening once a year will cost 8800.43 RMB, 5781.70 RMB, and 13825.04 RMB more for each additional QALY, which is lower than the willingness of Chinese people to pay and is less than twice the GDP of Xinjiang. The increased cost of obtaining an additional QALY is entirely worth it. All these are advantageous strategies. Conclusion Compared with the passive screening strategy, the cost and effect of the active screening strategy of once, twice, and once a year increase in turn, which can reduce the incidence of LTBI, tuberculosis, and tuberculosis death, and are all advantageous strategies. Continuous active screening of tuberculosis in critical populations is one of the key measures to quickly reduce the epidemic situation of tuberculosis. It is recommended to carry out regular screening for all close contacts of active tuberculosis patients. Reasonably allocate health resources, and propose reasonable screening methods for different age groups and critical groups.
Cross-Sectional Study of the Relationship between Trait Emotional Intelligence and Career Adaptability of Chinese Youths
Authors: Pong Hok Ko , Leung Chi Hung 
Published: July 2022

Abstract
Background: This research examined the relationship between trait emotional intelligence and the career adaptability of Chinese youths in Hong Kong.Method: Cross-sectional data (N = 500) were collected from two universities in 2019 and 2020. The 2019 sample consisted of 256 Chinese university students (117 males, 139 females; ages 21-25). The 2020 sample included 244 Chinese university students (132 males, 112 females; ages 21-25). The participants were asked to complete the Wong and Law Emotional Intelligence Scale (WLEIS) to evaluate their emotional intelligence in the domains of self-emotion appraisal, other people's emotion appraisal, regulation of emotion, and use of emotion. The participants completed the Career Adapt-Abilities Scale (CAAS) to assess their career adaptability in the areas of concern, control, curiosity, and confidence. Results: All domains of trait emotional intelligence were positively associated with career adaptability. Multiple Regression analysis showed that self-emotion appraisal and other people's emotional appraisal were the most predictive of career adaptability. Together, these two dimensions of emotional intelligence explained 12.5%, 26.2%, 13.4% and 69.4% of the variance in students’ concern, control, curiosity, and confidence in relation to career adaptability, respectively. Conclusion: The results highlight the importance of incorporating emotional intelligence into the curriculum for students, so they are better prepared for changes over the course of their careers.
Interobserver variation in the assessment of HER2 low expression in breast cancer: can we improve by adjusting criteria? An international interobserver study.
Authors: Navarro Ximena Baez , Bockstal Mieke Rosalie van , Nawawi Diënna , Broeckx Glenn , Colpaert Cecile , Doebar Shusma Charlane , Hogenes Marieke C.H. , Koop Esther , Lambein Kathleen , Peeters Dieter J.E. , Sinke Renata , Brakel Johannes Bastiaan van , Starre-Gaal José van der , Vegt Bert Van der , de Vijver Koen Van , Vreuls Celien P.H. , Vreuls Willem , Westenend Pieter , Deurzen Carolien van 
Published: July 2022

Abstract
The classification of Human Epidermal Growth Factor Receptor 2 (HER2) expression is optimized to detect HER2-amplified breast cancer (BC). However, novel HER2-targeting agents are also effective for BCs with low levels of HER2. This raises the question whether the current guidelines for HER2-testing are sufficiently reproducible to identify HER2 low BC. The aim of this multicenter international study was to assess the interobserver agreement of HER2 low scoring according to the current American Society of Clinical Oncology/College of American Pathologists (ASCO/CAP) guidelines. Furthermore, we evaluated whether the agreement improved by redefining immunohistochemistry (IHC) scoring criteria, or by adding fluorescent in situ hybridization (FISH). We performed a two-round study of 105 non-amplified BCs. During the first assessment, sixteen pathologists used the latest version of the ASCO/CAP guidelines. After a consensus meeting, the same pathologists scored the same digital slides using modified IHC scoring criteria based on the 2007 ASCO/CAP guideline, and an extra ‘ultralow’ category was added. Overall, the interobserver agreement was limited (4.7% of cases with 100% agreement) in the first round, but this improved by clustering IHC categories. In the second round, the highest reproducibility was seen when comparing IHC 0 versus the grouped cluster of ultralow/1+/2+ (74.3% of cases with 100% agreement). FISH results were not statistically different between HER2 0 and HER2 low cases, regardless of the IHC criteria used. In conclusion, our study suggests that the modified 2007 ASCO/CAP criteria were more reproducible to distinguish HER2 0 from HER2 low cases as compared to the 2018 ASCO/CAP criteria. However, the reproducibility was still moderate, which was not improved by adding FISH. This could lead to suboptimal selection of patients eligible for novel HER2-targeting agents. There is a need for clearer, more reproducible IHC definitions, training and/or development of more accurate methods to detect HER2 low BC.
Modeling tropospheric zenith wet delays in the Chinese mainland based on machine learning
Authors: Li Qinzheng , Yuan Linguo , Jiang Zhongshan 
Published: July 2022

Abstract
The neutral atmospheric refraction effect is one of the main error sources in the analyses of space geodetic data and its modeling is still limited due to the high variations of the atmospheric water vapor. In this study, the tropospheric zenith wet delay (ZWD) modeling was realized based on the nonlinear regression analysis of 7 years (2013–2019) of radiosonde data at 182 sites in the mainland of China and the surroundings through two machine learning (ML) approaches including the back propagation neural network (BPNN) and random forest (RF). Furthermore, the forecasting performance of the ML-based models and other formulae for ZWD calculation was assessed by the comparisons with the numerical integration of temperature and humidity profiles at discrete sites for the year 2020. Our results show that the RF-based and BPNN-based blind ZWD models obtain an overall accuracy of 4.7 cm in the mainland of China, which is slightly superior to that of the empirical GPT3 model (RMS error: 4.8 cm). On the other hand, when sites are accessible to surface meteorological data, the RF-based and BPNN-based models with meteorological parameterization (CZWD-C and CZWD-F) can achieve overall accuracies of 3.5 cm and 3.7 cm in the Chinese mainland, respectively, whose accuracies are better than that of the traditional Saastamoinen model (RMS error: 4.4 cm) and Askne and Nordius (1987) formula (RMS error: 4.0 cm). Moreover, ZWD forecasting accuracy in the mainland of China is significantly improved by introducing surface meteorological parameters into the functional formulation, in particular with the surface water vapor pressure. Concerning the spatial distribution of model accuracy, it can be found that these empirical ZWD models such as the GPT3 exhibit prominent large RMS errors exceeding 6 cm in the regions with Indian monsoon climate and East Asia monsoon climate types. Whereas the ML-based models with meteorological parameterization can improve ZWD forecasting accuracy across the mainland of China, especially in these regions with monsoon climate patterns.
Research on pulse transmission characteristics based on combined dispersion- decreasing fiber loop mirror
Authors: Zhang Qiaofen , Pang Liangyu , Wang Guitang , Gao Zihao , Chen Chubang 
Published: July 2022

Abstract

This paper investigates a combined dispersion-decreasing fiber loop mirror consisting of a fourth order super-Gaussian dispersion-decreasing fiber and a Gaussian dispersion-decreasing fiber. The length ratio of the two optical fibers in the loop mirror is analyzed and optimized to achieve a high-quality ultra-short output pulse. The results show that the optimal output pulse with no pedestal and a high compression ratio of F = 49.6 can be obtain at the fiber length L = 4.3km. Compared with the traditional dispersion-decreasing fiber loop mirror, the compression ratio is increased by 18.5 times, achieving ultra-short pulse output at the picosecond level.
Association between testosterone and bone mineral density in females aged 40-60 years from NHANES 2011- 2016
Authors: Zhang Han , Ma Kun , Li Run-Min , Li Jia-ni , Gao Shan-feng , Ma Lin-na 
Published: July 2022

Abstract
Introduction:
Growing evidence indicates that testosterone is a conspicuous marker for assessing male bone mineral density (BMD). However, research regarding testosterone levels and BMD is sparse and controversial for females. Hence, we aimed to investigate the association between testosterone levels and BMD among adult females aged 40–60 years in America.
Methods
In this cross-sectional study, all individuals were part of the National Health and Nutrition Examination Survey (2011–2016). A weighted general linear model was used to estimate the association between testosterone and lumbar BMD. Age, race, income level, education level, body mass index (BMI), blood urea nitrogen (BUN) level, serum uric acid (UA) level, serum calcium (Ca) level, serum phosphorus (P) level, oral contraceptive use, female hormones use(estrogen and progesterone), smoking status, drinking status were adjusted using a weighted multiple regression model.
Results
We included 2198 female individuals in the study, testosterone levels were positively associated with lumbar BMD after adjusting for all the covariates (β = 0.0008, 95% confidence interval = 0.0001, 0.0015, P < 0.05). Subgroup analysis showed that the results remained stable.
Conclusions
In US adults female aged 40–60 years, the testosterone level was an independent positive correlation with the lumbar BMD after adjusting for covariates. Based on our findings, testosterone may be a marker for predicting osteoporosis in females.
ATR1 Angiotensin II Receptor Reduces Hemoglobin S Polymerization, Phosphatidylserine Exposure and Increases Deformability of Sickle Cell Disease Erythrocytes
Authors: Nobre Camila Cristina Guimarães , Reis Evelyn Mendonça , Teixeira-Alves Lyzes Rosa , Miranda-Alves Leandro , Berto-Junior Clemilson 
Published: July 2022

Abstract
Background: Ang II (Ang II) regulates blood volume and stimulates erythropoiesis through AT1 (ATR1) and AT2 (ATR2) receptors, being found in multiple tissues, including erythrocytes. Sickle cell disease (SCD) patients presents altered Ang II (Ang II) levels.Hypothesis: Hemoglobin S polymerization, erythrocyte adhesion, deformability and eryptosis are important features of mature erythrocyte, therefore, our hypothesis is Ang II affect these parameters and, if does, which would be the influence of AT1R and AT2R in these effects.Methods: A Polymerization Assay (PA), static adhesion, deformability and annexin V binding were performed in SCD erythrocytes samples adding Ang II, ATR1 antagonist (losartan or eprosartan), and ATR2 antagonist (PD123319).Results: Through the PA test, we observed a dose-dependent polymerization inhibition effect when comparing Ang II to control. Losartan did not affect nor the level nor the rate of Ang II inhibition, while PD123319 showed an increased level of protection against polymerization and eprosartan brought levels back to control. Ang II does not change static adhesion but was able to reduce eryptosis in the presence of PD123319. Also, ATR1 shows a positive effect increasing deformability.Conclusion: our data shows that ATR1 is important for maintenance of erythrocyte physiological function in SCD and for prolonging its life.
The impact of age on rectal cancer treatment, complications and survival
Authors: Høydahl Øystein , Edna Tom-Harald , Xanthoulis Athanasios , Lydersen Stian , Endreseth Birger Henning 
Published: July 2022

Abstract
Background The number of older patients with rectal cancer is increasing. Treatment outcome discrepancies persist, despite similar treatment guidelines. To offer the oldest patients optimal individually adjusted care, further knowledge is needed regarding treatment strategy and outcome. The present study aimed to evaluate treatment, postoperative complications, and survival in older patients treated for rectal cancer. Methods This retrospective study included all 666 patients (n=255 females, n=411 males) treated for rectal cancer at Levanger Hospital during 1980-2016 (n=193 <65 years, n=329 65-79 years, n=144 ≥80 years). We performed logistic regression to analyse associations between complications, 90-day mortality, and explanatory variables. We performed a relative survival analysis to identify factors associated with short- and long-term survival.Results Despite a similar distribution of cancer stages across age-groups, patients aged ≥80 years were treated with a non-curative approach more frequently than younger age groups. Among patients aged ≥80 years, 42% underwent a non-curative treatment approach, compared to 25% of patients aged <65 years, and 25% of patients aged 65-79 years. The 90-day mortality was 15.3% among patients aged ≥80 years, compared to 5.7% among patients aged <65 years, and 9.4% among patients aged 65-79 years. Among 431 (65%) patients treated with a major resection with curative intent, the 90-day mortality was 5.9% among patients aged ≥80 years (n=68), compared to 0.8% among patients aged <65 years (n=126), and 3.8% among patients aged 65-79 years (n=237). The rate of postoperative complications was 47.6%. Pneumonia was the only complication that occurred more frequently in the older patient group. The severity of complications increased with three factors: age, American Society of Anaesthesiologists score, and >400 ml perioperative blood loss. Among patients that survived the first 90 days, the relative long-term survival rates, five-year local recurrence rates, and metastases rates were independent of age.Conclusion Patients aged ≥80 years were less likely to undergo a major resection with curative intent and experienced more severe complications after surgery than patients aged <80 years. When patients aged ≥80 years were treated with a major resection with curative intent, the long-term survival rate was comparable to that of younger patients.
Associations between traumatic event experiences, psychiatric disorders, and suicidal behavior in the general population of Afghanistan: findings from Afghan National Mental Health Survey
Authors: Sabawoon Ajmal , Keyes Katherine M , Karam Elie , Kovess-Masfety Viviane 
Published: July 2022

Abstract
Background: The role of traumatic event exposure and psychiatric disorders as central risk factors for suicidal behavior has been established, but there is limited data in high conflict regions with significant trauma exposures such as Afghanistan. Methods: A nationally-representative, cross-sectional survey was conducted through systematic stratified random sampling in 8 regions of Afghanistan in 2017 (N=4,474). Well-validated instruments were used to establish trauma exposure, psychiatric disorders. Death preference, suicidal ideation, plan, and attempts were assessed. Results: In the total sample, 2.2% reported suicidal ideation in the past 12-months, and 7.1% of respondents reported that they had suicidal ideation at some point in their lives; 3.4% reported a suicide attempt. Women were at higher risk than men. All traumatic event exposures were strongly associated with suicidal behavior. Respondents who reported experiencing sexual violence were 4.4 times more likely to report lifetime suicide attempts (95% CI: 2.3-8.4), and 5.8 times more likely to report past 12-month suicidal ideation (95% CI: 2.7-12.4). Associations were strong and significant for all psychiatric disorders related to suicidal behavior. Respondents who met criteria for major depressive episodes (OR=9.8; 95% CI: 5.9-16.1), generalized anxiety disorder (OR=9.2; 95% CI: 5.2-16.3), and PTSD (OR=9.3; 95% CI: 5.5-15.7) had the highest risk of past 12-month suicidal ideation. Conclusions: Traumatic event exposures and psychiatric disorders increase risk of suicidal behavior in the Afghan general population; women are at high risk. Interventions to reduce trauma exposure, including expansion of a mental health workforce in the region, is critically important.