bluuebunny/crossref_metadata_2025_split huggingface dataset:
Rasch analysis of the 32-item motor function measure in ambulant patients with Duchenne muscular dystrophy
Authors: Huang Meihuan , Chen Turong , Zhou Chunming , Wang Yujuan , Zeng Hongwu , Lu Xinguo , Cao Jianguo 
Published: October 2022

Objective This study analyzed the 32-item Motor Function Measure in a cohort of ambulatory patients with Duchenne muscular dystrophy using Rasch measurement methods. Design This is a psychometric study. Setting Rehabilitation centre of a large public children's hospital in Shenzhen, China. Participants Data from 176 genetically confirmed ambulant patients with Duchenne muscular dystrophy (mean age 7.3 years, SD 2.3 years, range 3.1–13.1 years) were analyzed. Results Rasch analyses supported the Motor Function Measure domain D1 as a reliable (person reliability  =  0.88, person separation index  =  2.71) and valid (acceptable targeting, little misfit, minimal category disordering) measure in ambulant patients with Duchenne muscular dystrophy. Remodelling the domain D1 by collapsing item 25 from 4 to 3 response categories addressed the problematic disordered thresholds, resulting in a rebuilt domain D1 with enhanced measurement properties. However, findings for domains D2 and D3 did not fulfil most Rasch model expectations. There were disordered thresholds for most items in domains D2 and D3, with low reliability coefficients, item mistargeting and misfit, and large ceiling effects. Conclusion Rasch analyses confirmed that the Motor Function Measure domain D1 was reliable and valid and provided a unidimensional measure for motor function in ambulant Duchenne muscular dystrophy patients. Accuracy of measurement had been enhanced through remodelling, and a rebuilt domain D1 with category collapsing for item 25 was proposed. The analysis revealed multiple limitations of the domains D2 and D3 that certain essential psychometrics were poorly met and, therefore, should be used with caution in this patient group.
Application value of T2 fluid-attenuated inversion recovery sequence based on deep learning in static lacunar infarction
Authors: Hou Yanzhen , Liu Qian , Chen Jialing , Wu Bin , Zeng Feihong , Yang Zhongxian , Song Haiyan , Liu Yubao 
Published: October 2022

Background Regular monitoring of static lacunar infarction (SLI) lesions plays an important role in preventing disease development and managing prognosis. Magnetic resonance imaging is one method used to monitor SLI lesions. Purpose To evaluate the image quality of the T2 fluid-attenuated inversion recovery (T2-FLAIR) sequence using artificial intelligence-assisted compressed sensing (ACS) in detecting SLI lesions and assess its clinical applicability. Methods A total of 42 patients were prospectively enrolled and scanned by T2-FLAIR. Two independent readers reviewed the images acquired with accelerated modes 1D (acceleration factor 2) and ACS (acceleration factors 2, 3, and 4). The overall image quality and lesion image quality were analyzed, as were signal-to-noise ratio (SNR), contrast-to-noise ratio (CNR), and number of lesions between groups. Results The subjective assessment of overall brain image quality and lesion image quality was consistent between the two readers. The lesion display quality and the overall image quality were better with the traditional 1D acceleration method than with the ACS accelerated method. There was no significant difference in the SNR of the lacunar infarction in the images between the groups. The CNR of the images with the 1D acceleration mode was significantly lower than that of images with the ACS acceleration mode. Images with the 1D, ACS2, and ACS3 acceleration modes showed no significant differences in terms of detecting lesions but scan time can be reduced by 40% (1D vs. ACS3). Conclusion ACS acceleration mode can greatly reduce the scan time. In addition, the images have good SNR, high CNR, and strong SLI lesion detection ability.
An assessment of drug and substance abuse prevalence: a cross-sectional study among undergraduates in selected southwestern universities in Nigeria
Authors: Olanrewaju John Afees , Hamzat Ezekiel Olumide , Enya Joseph Igbo , Udekwu Maureen Obiageli , Osuoya Quincy , Bamidele Richard , Feyisike Johnson Olawumi , Johnson Babajide Semeton , Olanrewaju Ifedolapo , Owolabi Joshua Oladele 
Published: October 2022

Objective This cross-sectional study aimed to assess the prevalence and awareness of drug and substance abuse among undergraduates in four southwestern universities in Nigeria. Methods The sample of 400 students included 100 male and female students in the 15- to 29-year age range from each of the four selected universities in southwest Nigeria between December 2019 and June 2020. Descriptive statistics and Pearson chi-square tests were used for data analysis using the statistical package for social sciences (SPSS). Results Four hundred students satisfied the inclusion criteria and suitably completed the questionnaire. Most respondents were in the 15- to 19-year and 20- to 24-year age groups and were female (68%). Drug and substance abuse prevalence was 45.7%; one in every four students abused substances despite an aggregate risk awareness level of 94.6%. Alcohol and cigarettes—legally and socially accepted substances—were the most abused (61.5% and 54.5%, respectively). Codeine-containing syrup and tramadol topped the list of drugs, ranking higher than cannabis. The major motive was to ‘get high’ and numb emotional problems caused by predominantly socioeconomic and societal factors. Conclusion The study showed a notable prevalence of drug and substance abuse across the selected universities in southwest Nigeria.
Maternal retention and early infant HIV diagnosis in a prospective cohort study of HIV-positive women and their children in Malawi
Authors: Giuliano Marina , Orlando Stefano , Andreotti Mauro , Mthiko Bryan , Mphwere Robert , Kavalo Thom , Ciccacci Fausto , Marazzi Maria Cristina , Floridia Marco 
Published: October 2022

Background Post-partum loss to follow-up and lack of early HIV infant diagnosis (EID) can significantly affect the efficiency of programs for the prevention of mother-to-child transmission. Methods In a prospective observational study 167 women were enrolled at week 36 of gestation and followed with their infants up to one year after delivery. Retention was defined as the proportion of women who attended the 12 months visit and EID as an HIV PCR test performed within 2 months. Determinants for retention and EID were assessed in univariate analyses and in multivariable logistic regression models. Results Women lost to follow-up (24/167 or 14.4%) had a shorter duration of antiretroviral therapy (ART) at enrolment in comparison to women retained in care ( p = 0.025). Lack of EID (occurring in 18.9% of the cases) was directly correlated, although not significantly, with a history of child death ( p = 0.071), a higher educational level ( p = 0.083), and female infant gender ( p = 0.064). Conclusions Longer duration of ART at enrolment significantly predicted a better post-partum retention, suggesting that specific counselling interventions should be targeted to recent ART initiators. A low proportion of infants did not receive an EID, but predictive factors were difficult to identify.
Effect of α-aluminium oxide nano additives with Sal biodiesel blend as a potential alternative fuel for existing DI diesel engine
Authors: Sharma Abhishek , Pali Harveer Singh , Kumar Manish , Singh Nishant Kumar , Rahim Erween Abd , Singh Yashvir , Gupta Naveen Kumar 
Published: October 2022

The increasing demand, rapid consumption, price increase, limited reserves, and environmental concern due to pollution produced by conventional fossil fuel (diesel & gasoline) are a few reasons why biofuels need to be explored. The present paper employs a systematic methodology to examine the performance of a 20% volumetric blend of Sal biodiesel (S20) blended with diesel using α-aluminium oxide (α-Al2O3) nanoparticles (NP) as additives and is compared with a diesel under like circumstances. The central composite design, Box-Behnken design (BBD) based response surface methodology, and desirability tests are used in the organized experiments on a diesel engine configuration to facilitate calibration. The created multivariate regression model yields all of the best engine inputs. Interaction effects are used to determine the most influential element by observing the interaction of two distinct input factors on a single response. According to the desirability tests, the highest estimated desirability was 0.579; the optimal input parameters found are 21°bTDC injection timing (IT), 238 bar injection pressure (IOP), 17 compression ratio (CR), and 74 ppm concentration of α-Al2O3NP, estimated the optimized response of brake thermal efficiency (BHTE) 31.18%, brake specific fuel consumption (BSFC) 0.2975 kg/kWh, carbon monoxide (CO) 0.0887%, hydrocarbon (HC) 31 ppm, oxide of nitrogen (NOx) 677 ppm, and smoke level 54.92%. These predicted values were validated with experimental results, and errors were within the range. The nanoparticle combination sample offers improved brake thermal efficiency (BTHE) and lower BSFC rate than the S20 while testing for the optimal parametric condition. Graphical abstract [Formula: see text]
Prediction and mitigation of train-induced vibrations of over-track buildings on a metro depot: Field measurement and numerical simulation
Authors: Wang Siqi , Cao Zhigang , Xu Yifei , Xiao Zheng , Yuan Zonghao , Cai Yuanqiang , Gou Changfei 
Published: October 2022

To predict the vibration transmission of over-track buildings and investigate the effectiveness of countermeasures, a fully coupled three-dimensional vibration prediction model for over-track buildings with consideration of the pile–soil interaction (PSI) was proposed. The accuracy of this prediction model was validated with field data from in-situ vibration monitoring in a metro depot. The consideration of PSI improved prediction accuracy about the vibration of over-track buildings. Then the effectiveness of different mitigation measures (rail damper and ballast mat) was investigated by this prediction model. It was found that the vibration of over-track buildings was dominated by vertical vibration components. Rail dampers significantly reduced the vibration in the high-frequency range above 80 Hz, while the vibration in the low-frequency range below 10 Hz was amplificated. The insertion loss of ballast mats reached 10 dB in the frequency range above 40 Hz except at the resonance frequency of the track, and mitigation effectiveness gradually decreased with increasing story height. This proposed method can predict the vibration level within over-track buildings and is an effective tool to guide the vibration mitigation design of over-track buildings.
Venous thromboembolism and major adverse cardiovascular events in patients with hip fractures suffering from SARS-CoV-2 infection: a systematic review
Authors: Koutalos Antonios A , Ntalouka Maria P , Angelis Fragkiskos A , Hantes Michael , Arnaoutoglou Eleni 
Published: October 2022

Introduction: Hip fractures represent 1 of the most common injuries in older adults. They are associated with increased perioperative morbidity and mortality. Additionally, current research suggests that SARS-COV-2 infection may worsen the prognosis of the hip fracture patients who undergo hip fixation. The aims of the present study were: (1) to determine the rate of specific adverse events including VTE (venous thromboembolism) and major adverse cardiovascular events (MACEs) in patients with hip fracture and concomitant SARS-CoV-2 infection undergoing surgery; and (2) to examine if the aforementioned population is at increased risk for VTE and MACEs, when compared to SARS-CoV-2 free patients with hip fracture. Methods: PubMed, EMBASE, Cochrane, Web of Science, Google scholar and medRxiv were searched from March 2020 to January 2021 for English language studies with patients suffering from hip fractures and SARS-COV-2 -CoV-2. 2 researchers were involved in the data extraction and the quality assessment of the studies respectively. Results: The literature search yielded a total of 1256 articles of which 14 were included in the systematic review and 7 in the meta-analysis respectively. The estimated pooled rate for VTE and MACE were 4.3% and 6.3% respectively. Patients with hip fracture and concomitant SARS-CoV-2 infection who undergo surgery are at increased risk for VTE, when compared to SARS-CoV-2 free patients (odds ratio 2.8 [95% CI, 1.1–7.1]). These patients are also at increased risk for MACE postoperatively as indicated by the odds ratio 2.4 (95% CI, 1.0–5.8). The quality of the studies was moderate. Conclusions: Although there is a lack of high-quality data it seems that patients with hip fractures and concomitant SARS-CoV-2 infection are facing a 2.8 and 2.4 times increased risk for VTE and MACE.
Full bridge analysis of nonlinear vortex-induced vibration considering incomplete span-wise correlation of vortex-induced force
Authors: Zhu Le-Dong , Meng Xiao-Liang , Tan Zhongxu , Zhu Qing 
Published: October 2022

Responses of vortex-induced vibration (VIV) of long-span bridges are commonly measured at first via wind tunnel tests of sectional model and then converted to the prototype ones of the corresponding full bridges by some approximate formulae. In this paper, a time-domain full bridge analysis method was presented for predicting nonlinear VIV responses mode-by-mode based on a polynomial type of nonlinear mathematical model of vortex-induced force (VIF) on bridge deck cross section. In this method, the motion-dependant self-excited force (SEF) components of VIF were regarded as fully correlated span-wise in the case of smooth flow, while the motion-independent harmonic pure vortex-shedding force (PVSF) component of VIF was regarded as incompletely correlated along the bridge span. To take into account the incomplete span-wise correlation of PVSF, an equivalent generalized PVSF including the effect of the incomplete span-wise correlation of PVSF was defined by using a span-wise correlation coefficient of PVSF which could be obtained through a sectional model wind tunnel test of simultaneous pressure measurement. As an application example, the VIV responses of 12 vertical modes of a steel box deck cable stayed bridge with a main span of 688 m were analysed, and were compared with those converted with two approximate converting formulae, respectively, based on Scanlan’s linear and nonlinear mathematical model of VIF. It is found that the influence of the incomplete span-wise correlation of PVSF on the bridge VIV response is very small and can then be ignored.
Effect of palmyra sprout fiber and biosilica on mechanical, wear, thermal and hydrophobic behavior of epoxy resin composite
Authors: Alshahrani Hassan , Pathinettampadian Gurusamy , Gujba Abdullahi K , Prakash Vincent Rethnam Arun 
Published: October 2022

In this study, natural fiber epoxy composites were prepared using palmyra sprout fiber and red matta rice husk ash(RHA) biosilica. This paper mainly aims to investigate the mechanical, wear resistance, thermal stability as well as water absorption behaviour of naturally obtained novel fiber with red matta biosilica in epoxy based composites. The fiber’s surface was treated by base, while the biosilica particles were treated by amino-silane. The composites were fabricated by hand lay-up process and characterized based on ASTM standards. According to the results the highest tensile and flexural strength observed for the composite is about 147 MPa and 211 MPa for 3 vol. % of biosilica with 30 vol. % of fiber. Izod impact toughness reveals the maximum impact resistance up to 5.82 J. Increment in reinforcement vol. % shows increased hardness. Wear properties represents the composite designations EPB3 retains good wear resistances for 3 vol. % of biosilica. Similarly, thermal stability improved by the addition of biosilica of 3 vol. %. Water absorption results reveal that, the addition of reinforcements marginally affects the contact angle. Such mechanically improved, wear resistible and thermally stable natural composites could be used in automotives, industrial and defense applications as well as in household appliances.
Distal radial artery approach is safe and effective for cerebral angiography and neuroendovascular treatment: A single-center experience with ultrasonographic measurement
Authors: Umekawa Motoyuki , Koizumi Satoshi , Ohara Kenta , Ishigami Daiichiro , Miyawaki Satoru , Saito Nobuhito 
Published: October 2022

Background The transradial artery approach to cerebral angiography can reduce both patient stress following examination and the risk of major complications due to hematoma. Recently, the distal radial artery approach (DRA) has garnered attention in cardiology as a minimally invasive method. DRA is also considered applicable to neurosurgery, although concerns about procedural difficulty and complications persist. Therefore, this study aimed to evaluate the efficacy of the DRA in cerebral angiography and neuroendovascular treatment. Methods We retrospectively selected 30 consecutive patients for whom the DRA was attempted for cerebral angiography at our hospital. The patients’ age, sex, height, weight, and medical history information was collected and correlated with successful puncture and complications. The diameter of the distal radial artery (RA) was measured using ultrasonography. Results The median patient age was 67 years (range, 32–87 years) and 21 (70%) were men. The median diameter of the distal RA was 2.3 mm (range, 1.7–3.2 mm). Distal RA puncture was successful in 23 patients (77%) and no complications were noted; however there was no significant correlation between successful puncture and any of the patient factors. Carotid artery stenting and preoperative tumor embolization were performed via DRA in six and three cases, respectively. Although puncture site hematoma occurred in only one case, all treatments were successful, and no major complications were observed. Conclusion DRA can be safely used for cerebral angiography and neuroendovascular treatment.
Building better pediatric surgeons: A sentiment analysis of online physician review websites
Authors: Butler Liam R , Tang Justin E , Hess Skylar M , White Christopher A , Arvind Varun , Kim Jun S , Allen Abigail K , Ranade Sheena C 
Published: October 2022

Purpose:Physician review websites are a heavily utilized patient tool for finding, rating, and reviewing surgeons. Natural language processing such as sentiment analysis provides a comprehensive approach to better understand the nuances of patient perception. This study utilizes sentiment analysis to examine how specific patient sentiments correspond to positive and negative experiences in online reviews of pediatric orthopedic surgeons.Methods:The online written reviews and star ratings of pediatric surgeons belonging to the Pediatric Orthopaedic Society of North America were obtained from healthgrades.com . A sentiment analysis package obtained compound scores of each surgeon’s reviews. Inferential statistics analyzed relationships between demographic variables and star/sentiment scores. Word frequency analyses and multiple logistic regression analyses were performed on key terms.Results:A total of 749 pediatric surgeons (3830 total online reviews) were included. 80.8% were males and 33.8% were below 50 years of age. Male surgeons and younger surgeons had higher mean star ratings. Surgeon attributes including “confident” (p < 0.01) and “comfortable” (p < 0.01) improved the odds of positive reviews, while “rude” (p < 0.01) and “unprofessional” (p < 0.01) decreased these odds. Comments regarding “pain” lowered the odds of positive reviews (p < 0.01), whereas “pain-free” increased these odds (p < 0.01).Conclusion:Pediatric surgeons who were younger, communicated effectively, eased pain, and curated a welcoming office setting were more likely to receive positively written online reviews. This suggests that a spectrum of interpersonal and ancillary factors impact patient experience and perceptions beyond surgical skill. These outcomes can advise pediatric surgeons on behavioral and office qualities that patients and families prioritize when rating/recommending surgeons online.Level of evidence:IV
RNA Sequencing and Gene Ontology Analysis in Acute Invasive Fungal Sinusitis
Authors: David Abel P. , Loftus Patricia A. , Russell Matthew S. , Goldberg Andrew N. , El-Sayed Ivan H. , Jan Taha A. , Roland Lauren T. 
Published: October 2022

Background Acute invasive fungal sinusitis (AIFS) is an aggressive and dangerous disease of the paranasal sinuses with high morbidity and mortality. The immune response at the level of the nasal mucosa, the site of entry, has not been previously evaluated. Objective To evaluate differential gene expression in the sinonasal mucosa of AIFS patients as compared to control patients using RNA sequencing. Methods Sinonasal tissue samples were prospectively obtained from consenting patients undergoing surgery between November, 2020 and November, 2021. RNA extraction and sequencing were performed and differential expression was analyzed to detect transcriptional differences between patient groups. Results Tissue samples were collected from 4 patients with active AIFS diagnoses, 2 patients with recovered AIFS, 1 patient with a diagnosis of non-invasive fungal ball, and 4 healthy controls. 255 genes were differentially expressed in AIFS patients as compared to control patients. Specific Gene Ontology (GO) biological processes that were identified as differentially expressed in AIFS patients as compared to controls included the following: 1. GO:0007155 (cell adhesion), 2. GO:0030199 (collagen fibril organization) and 3. GO:0001525 (angiogenesis). Conclusion Transcriptional differences were noted between AIFS and control patients in sinonasal tissue samples. Future work is necessary to determine causes of the differential gene expressions between AIFS and control patients, specifically those who are immunosuppressed, or with preexisting non-invasive forms of fungal sinusitis, to guide treatment and prevention strategies.