bluuebunny/crossref_metadata_2025_split huggingface dataset:
This is GlycoQL
Authors: Hayes Catherine , Daponte Vincenzo , Mariethoz Julien , Lisacek Frederique 
Published: September 2022

AbstractMotivationWe have previously designed and implemented a tree-based ontology to represent glycan structures with the aim of searching these structures with a glyco-driven syntax. This resulted in creating the GlySTreeM knowledge-base as a linchpin of the structural matching procedure and we now introduce a query language, called GlycoQL, for the actual implementation of a glycan structure search.ResultsThe methodology is described and illustrated with a use-case focused on Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) spike protein glycosylation. We show how to enhance site annotation with federated queries involving UniProt and GlyConnect, our glycoprotein database.Availability and implementationhttps://glyconnect.expasy.org/glycoql/.
HMI-PRED 2.0: a biologist-oriented web application for prediction of host–microbe protein–protein interaction by interface mimicry
Authors: Lim Hansaim , Tsai Chung-Jung , Keskin Ozlem , Nussinov Ruth , Gursoy Attila 
Published: September 2022

AbstractSummaryHMI-PRED 2.0 is a publicly available web service for the prediction of host–microbe protein–protein interaction by interface mimicry that is intended to be used without extensive computational experience. A microbial protein structure is screened against a database covering the entire available structural space of complexes of known human proteins.Availability and implementationHMI-PRED 2.0 provides user-friendly graphic interfaces for predicting, visualizing and analyzing host–microbe interactions. HMI-PRED 2.0 is available at https://hmipred.org/.
Spatial organization of neuron–astrocyte interactions in the somatosensory cortex
Authors: Baraibar Andrés M , Belisle Lindsey , Marsicano Giovanni , Matute Carlos , Mato Susana , Araque Alfonso , Kofuji Paulo 
Published: September 2022

Abstract
Microcircuits in the neocortex are functionally organized along layers and columns, which are the fundamental modules of cortical information processing. While the function of cortical microcircuits has focused on neuronal elements, much less is known about the functional organization of astrocytes and their bidirectional interaction with neurons. Here, we show that Cannabinoid type 1 receptor (CB1R)-mediated astrocyte activation by neuron-released endocannabinoids elevate astrocyte Ca2+ levels, stimulate ATP/adenosine release as gliotransmitters, and transiently depress synaptic transmission in layer 5 pyramidal neurons at relatively distant synapses (˃20 μm) from the stimulated neuron. This astrocyte-mediated heteroneuronal synaptic depression occurred between pyramidal neurons within a cortical column and was absent in neurons belonging to adjacent cortical columns. Moreover, this form of heteroneuronal synaptic depression occurs between neurons located in particular layers, following a specific connectivity pattern that depends on a layer-specific neuron-to-astrocyte signaling. These results unravel the existence of astrocyte-mediated nonsynaptic communication between cortical neurons and that this communication is column- and layer-specific, which adds further complexity to the intercellular signaling processes in the neocortex.
Rapid Determination of Preservatives in Cosmetics Using a Core–Shell Column
Authors: Tanaka Misa , Doi Takahiro , Takeda Akihiro , Nakamura Akihiko , Azuma Yuki , Kawaguchi Masami , Tagami Takaomi 
Published: September 2022

Abstract
Preservatives are frequently added to cosmetics to maintain product quality. Our laboratory quantifies 11 preservatives in cosmetics each year for regulatory purposes. In laboratories, many manufactures also analyze the preservatives in their products for quality control. To analyze many cosmetic samples, a rapid analysis method is required for efficiency. In this study, we developed a rapid method for the simultaneous determination of 11 regulated preservatives in cosmetics using a core–shell column by high-performance liquid chromatography. In this method, the 11 preservatives were separated within 17 min, which was approximately half the time reported in the previous study. The peak resolution for each preservative was &gt;2.6, the correlation coefficients of the calibration curves were &gt;0.9988, the percent recoveries were 92.0–111.9% and the relative standard deviations were &lt;3.5% (n = 3). The relative standard deviations among 6 researchers were &lt;4.7%. Thus, it is an effective rapid determination method for the analysis of preservatives in cosmetics.
Extraction-HPLC Green Methodology for Determination of Phenolic Compounds from Fruits by using Brij-58 Surfactant
Authors: Kori Shivpoojan , Sharma Shweta 
Published: September 2022

Abstract
A green, simple and cost-effective, validated high-performance liquid chromatographic (HPLC) with UV detector has been developed an analytical method for the simultaneous determination of the most significant phenolic compounds viz. Gallic acid (GA), Quercetin (QC) and Ferulic acid (FA). The detection limit of GA, QC, FA was 0.303, 0.168, 0.0976 μg/mL and quantitation limit was 0.918, 0.051, 0.295 μg/mL, respectively. All parameters of planned validated method were carried out as per the ICH guidelines. This analytical method was applied to determine the phenolic compounds in fruits cultivated in India. Phenolic compounds in fruits extract were quantified using regression equations. This method can be scaled up to determine the alkaloids from several medicinal and poisonous plants samples in pharmaceutical, forensics and industrial areas.
Ideology, political polarisation and agility of policy responses: was weak executive federalism a curse or a blessing for COVID-19 management in the USA?
Authors: Gasulla Óscar , Bel Germà , Mazaira-Font Ferran A 
Published: September 2022

AbstractWe investigate whether weak executive federalism was beneficial or damaging for COVID-19 management in the USA. We formulate a policy response model for subnational governments, considering the national government’s preferred policy, in addition to other factors, with incomplete and with complete information. The hypotheses derived are tested using econometric techniques. Our results suggest that ideological and political biases were more influential in a situation of incomplete information than in one of complete information. As such, weak executive federalism allowed more agile policy responses in Democrat-led states when information was incomplete, thus reducing the rates of incidence and mortality. When information was complete, ideological and political biases were found to be of no relevance at all.
Exploring Patient Perspectives on a 12-Week Online, Stress Reduction Intervention in Inflammatory Bowel Disease
Authors: Watt Makayla , Peerani Farhad , Madsen Karen , Siffledeen Jesse , Kroeker Karen , Lim Allen , Tandon Puneeta , Hyde Ashley 
Published: September 2022

Abstract

Background
Online stress reduction interventions may be useful adjuncts to standard medical therapies for inflammatory bowel disease (IBD). As part of the evaluation of a 12-week randomized control trial (RCT) of an online multicomponent stress reduction program, our aim for the current study was to use qualitative methods to more deeply explore the patient experience with the online programming.

Methods
Upon completion of the 12-week RCT, all intervention participants were invited to participate in semistructured interviews. A qualitative descriptive approach was used. Interviews were analyzed through a theoretical thematic analysis process, whereby transcripts were coded, and codes then grouped into larger categories and themes.

Results
A total of 56 interviews were analyzed with the emergence of 3 main themes: (1) IBD as a source of stress and uncertainty, (2) understanding the positive impacts of the stress reduction program, and (3) suggested strategies to enhance program desirability. IBD was described as causing uncertainty, significant disruptions to daily activities, and stress, which in turn worsened symptoms. The online program was associated with a perceived reduction in IBD symptom burden, an increased ability to manage daily and disease-associated stressors, and a more positive mindset. Variation in program content and fostering connections with others in the IBD community were identified as potential strategies to enhance future programming.

Conclusions
This qualitative companion study highlights the power of the patient voice to deepen our understanding of the impact of IBD, and the potential benefit of an online stress reduction program including suggestions for iterative refinement.
Inferior vena cava filter limb embolization to the right ventricle: a case report
Authors: Knox Abbey , Gimpel Damian , Harjit Singh Rajinder Singh , Burdeniuk Christine , Bennetts Jayme S 
Published: September 2022

AbstractBackgroundInferior vena cava (IVC) filters are used to prevent pulmonary embolism (PE) in patients at a high risk for venous thromboembolism with a contraindication to anticoagulation. Inferior vena cava filters are associated with rare but significant long-term complications such as filter fracture and embolization.Case summaryWe report the case of a 53-year-old female with an IVC filter inserted 8 years back for the management of recurrent bilateral PE resistant to anticoagulation. Imaging revealed an incidental finding of IVC filter limb fracture and migration to the right heart and the hepatic and renal veins. The patient remained asymptomatic with no impairment in cardiac, liver, or renal function. Due to a high operative risk, the broken IVC filter and embolized filter limbs were not retrieved.DiscussionThere is no consensus on the management of intracardiac embolization of IVC filters. Intravascular fragments may be removed by endovascular or surgical approaches, depending on the anatomical location. Following IVC filter insertion, an appropriate follow-up must be put in place to ensure removal and limit clinical sequelae that are otherwise avoidable. A multidisciplinary approach to the management of IVC filter fracture and embolization is recommended.
NESM: a network embedding method for tumor stratification by integrating multi-omics data
Authors: Li Feng , Sun Zhensheng , Liu Jin-Xing , Shang Junliang , Dai Lingyun , Liu Xikui , Li Yan 
Published: September 2022

Abstract
Tumor stratification plays an important role in cancer diagnosis and individualized treatment. Recent developments in high-throughput sequencing technologies have produced huge amounts of multi-omics data, making it possible to stratify cancer types using multiple molecular datasets. We introduce a Network Embedding method for tumor Stratification by integrating Multi-omics data. Network Embedding method for tumor Stratification by integrating Multi-omics pregroup the samples, integrate the gene features and somatic mutation corresponding to cancer types within each group to construct patient features, and then integrate all groups to obtain comprehensive patient information. The gene features contain network topology information, because it is extracted by integrating deoxyribonucleic acid methylation, messenger ribonucleic acid expression data, and protein–protein interactions through network embedding method. On the one hand, a supervised learning method Light Gradient Boosting Machine is used to classify cancer types based on patient features. When compared with other 3 methods, Network Embedding method for tumor Stratification by integrating Multi-omics has the highest AUC in most cancer types. The average AUC for stratifying cancer types is 0.91, indicating that the patient features extracted by Network Embedding method for tumor Stratification by integrating Multi-omics are effective for tumor stratification. On the other hand, an unsupervised clustering algorithm Density-Based Spatial Clustering of Applications with Noise is utilized to divide single cancer subtypes. The vast majority of the subtypes identified by Network Embedding method for tumor Stratification by integrating Multi-omics are significantly associated with patient survival.
The Association Between Midlife Leisure-Time Physical Activity and Hearing Loss in Late Life in the Atherosclerosis Risk in Communities Study
Authors: Martinez-Amezcua Pablo , Garcia Morales Emmanuel , Gabriel Kelley P , Dooley Erin E , Hornikel Bjoern , Coresh Josef , Lin Frank R , Pankow James S , Sharrett A Richey , Schrack Jennifer A , Sullivan Kevin J , Reed Nicholas , Deal Jennifer A , Palta Priya 
Published: September 2022

Abstract

Background
Hearing loss is highly prevalent in older ages and has several health consequences. Some cardiovascular risk factors are associated with worse hearing at older ages. Still, the role of midlife leisure-time physical activity (PA) as a risk factor for hearing loss is yet to be investigated.

Methods
Among 3 198 participants of the Atherosclerosis Risk in Communities study, we investigated the associations of midlife and change from mid- to late-life PA (assessed via modified Baecke questionnaire) with hearing loss (audiometric battery [worse-ear pure-tone average, and speech-in-noise test]) at older ages. We used regression analyses, adjusted for demographics, medical conditions, and noise exposure, to estimate differences in hearing between those who met and did not meet PA recommendations at midlife and at late life.

Results
A total of 1 386 (43.3%) participants met PA recommendations at midlife. These participants, compared to those who did not meet recommendations, had lower (better) pure-tone average by 1.51 (0.46, 2.55) decibels, identified 0.37 (0.01, 0.74) more words (better score) in the speech-in-noise test, and had a lower relative risk of having hearing loss at older ages (eg, relative risk ratio for severe hearing loss vs normal hearing = 0.70 [0.52, 0.95]). Similarly, those who persistently met PA recommendations from mid- to late life had, compared with those who did not, a better hearing at older ages.

Conclusions
Meeting PA public health recommendations in midlife and mid- to late life was associated with better hearing at older ages and reduced risk of hearing loss. Promoting adequate levels of PA may be an essential component of hearing care.
Angiotensin (1–7) Delivered Orally via Probiotic in Combination With Exercise: Sex-Dependent Influence on Health Span
Authors: Hernandez Abbi , Sun Yi , Banerjee Anisha , Yang YouFeng , Verma Amrisha , Li Qiuhong , Baptista Liliana , Buford Thomas W , Carter Christy S 
Published: September 2022

AbstractAge-related declines in physical and cognitive function can have tremendous, negative impacts on health span and quality of life. Therefore, we investigated the potential of utilizing a probiotic treatment to target the renin–angiotensin system (RAS) in conjunction with moderate exercise to ameliorate age-related declines in cognitive and physical function in aged rats. Herein we utilized a genetically modified angiotensin (1–7), which activates a “complementary” arm of the RAS through binding Mas (AT7) receptors. This process induces several beneficial physiologic effects, including decreased inflammation and enhanced physical/cognitive function. Thus, in this short research report, we suggest the efficacy of this Ang(1-7) releasing Lactobacillus paracasei (LPA) as either an alternative strategy to exercise, or more likely as an adjuvant to moderate exercise, for the prevention of both physical and cognitive decline especially in female rats.
Blunted Rest–Activity Circadian Rhythm Is Associated With Increased Rate of Biological Aging: An Analysis of NHANES 2011–2014
Authors: Xu Yanyan , Wang Xiaoling , Belsky Daniel W , McCall William V , Liu Yutao , Su Shaoyong 
Published: September 2022

AbstractImpaired rest–activity circadian rhythm has been associated with increased risk for morbidity and mortality. Animals with mutations in clock genes display accelerated aging and shortened life span. Whether impaired rest–activity circadian rhythm is also associated with processes of aging in humans has not been explored. We analyzed accelerometry and physiological data from 7 539 adults participating in the 2011–2014 waves of the U.S. National Health and Nutrition Examination Surveys. We used accelerometry data to compute rest–activity rhythm measurements. We used physiological data to compute measurements of biological aging according to 3 published algorithms: Klemera–Doubal method (KDM) Biological Age, PhenoAge, and homeostatic dysregulation (HD). In the models adjusting multiple covariates, participants with higher relative amplitude (RA) and interdaily stability (IS) and lower intradaily variability (IV) exhibited less advanced biological aging indexed by KDM and PhenoAge (effect sizes for 1-quantile increase in these rest–activity measurements ranged from 0.54 to 0.57 “years” for RA, 0.24 to 0.28 “years” for IS, and 0.24 to 0.35 “years” for IV, ps &lt; .001). Similar finding was observed for biological aging indexed by HD, but the significance was limited to RA with 1-quantile increase in RA associated with 0.09 log units decrease in HD (p &lt; .001). The results indicate that blunted rest–activity circadian rhythm is associated with accelerated aging in the general population, suggesting that interventions aiming at enhancing circadian rhythm may be a novel approach for the extension of a healthy life span.
Changes in Grandparental Childcare During the Pandemic and Mental Health: Evidence From England
Authors: Di Gessa Giorgio , Bordone Valeria , Arpino Bruno 
Published: September 2022

AbstractObjectivesPolicies aiming at reducing rates of hospitalization and death from coronavirus disease 2019 (COVID-19) encouraged older people to reduce physical interactions. In England, until July 2021, provision of care for grandchildren was allowed only under very limited circumstances. Evidence also suggests that reduced face-to-face interactions took a toll on mental health during the pandemic. This study aims to investigate associations between changes in grandchild care provision during the first 8/9 months of the pandemic and grandparents’ mental health.MethodsUsing prepandemic data from Wave 9 (2018/2019) and the second COVID-19 substudy (November/December 2020) of the English Longitudinal Study of Ageing, we first describe changes in grandchild care provision during the pandemic to then investigate, using regression models, associations between changes in grandchild care provision and mental health (depression, quality of life, life satisfaction), while controlling for prepandemic levels of the outcome variables.ResultsAbout 10% of grandparents stopped looking after grandchildren altogether during the first 9 months of the pandemic, with 22% reporting an overall decrease in the amount of grandchild care provided. Compared to grandparents who mostly maintained unchanged their grandchild care provision, those who stopped altogether and those who mostly reduced the amount of grandchild care provided were more likely to report poorer mental health, even accounting for prepandemic health.DiscussionWhile measures to limit physical contact and shield older people were necessary to reduce the spread of COVID-19, policymakers should acknowledge potential adverse consequences for mental health among grandparents who experienced changes in their roles as grandchild caregivers.
Relationship Quality Change Among Partnered Older Adults During the COVID-19 Pandemic
Authors: Wong Jaclyn S , Zhong Selena , Liu Hui 
Published: September 2022

AbstractObjectivesThe coronavirus disease 2019 (COVID-19) pandemic dramatically changed social life, but we know less about whether partnered relationships changed during this time. Because high-quality intimate relationships are key to many older Americans’ well-being, we explore whether, how, and for whom the pandemic changed relationship quality among partnered older Americans.MethodsNationally representative data from 1,642 partnered adults aged 50 and older come from the 2020 National Social Life, Health, and Aging Project COVID-19 Study. Multinomial logistic regression analyses estimate the likelihood of reporting improved, unchanged, or worsened relationship quality since the pandemic began across sociodemographic groups.ResultsTwo thirds of respondents reported that relationship quality stayed the same during the pandemic, 22.8% reported their relationship quality got better, and 10.5% reported their relationship quality got worse. Although women and the oldest old were less likely to report improved relationship quality, Black respondents were more likely to do so, even after controlling for explanatory variables.DiscussionResilience describes many partnered older adults’ experiences during the first year of the pandemic, suggesting that they were able to protect their partnerships during this public health crisis.
The Dynamics of Daily Life in Custodial Grandmothers
Authors: Infurna Frank J , Castro Saul A , Webster Britney A , Dolbin-MacNab Megan L , Smith Gregory C , Max Crowley D , Musil Carol 
Published: September 2022

AbstractObjectiveGuided by a life-course perspective, we examine the nature of daily life among custodial grandmothers (CGM) through documenting daily positive and negative affect, reporting daily negative and positive events, and emotional reactivity/responsiveness to daily negative and positive events. We also examine whether CGM age, adverse childhood experiences (ACEs), and social relationship quality with grandchild are associated with each indicator.MethodsWe applied multilevel models to 200 CGM (Mage = 61, SD = 5.66) who were recruited from across the United States and completed a daily survey for 14 consecutive days prior to commencing a randomized clinical trial.ResultsOlder age and reporting fewer ACEs were associated with better overall and less variability in daily well-being. Positive events were reported on 83% of days and negative events were reported on 56% of days. Daily well-being was lower when a negative event was reported and higher when a positive event was reported. Reporting more ACEs was associated with greater exposure to daily negative events and stronger gains in daily well-being when a daily positive event was reported. Older age was associated with lesser declines in daily well-being on days when a negative event was reported.DiscussionIn accordance with the life-course perspective, our findings illustrate how the timing of being a CGM (age) and the cumulative nature of development (ACEs) affect daily well-being and negative and positive events for CGM. Our discussion focuses on resources to consider when building resilience-focused interventions for promoting the health and well-being of CGM.
Second Medical Use Patents and Compensation for the Delay in Marketing Authorisations: The Curious Case of Vietnam
Authors: Le Van Anh 
Published: September 2022

Abstract
There has been a concern that developing countries which join new-generation FTAs might jeopardise their population’s access to medicines because those FTAs mandate TRIPS-plus patent standards. This article, however, argues that Vietnam, through its unusual legislative steps, has avoided increasing patent protection for medicines without (yet) violating international obligations. Its practice is examined via two specific patent-related issues: second medical uses and compensation for the delay in marketing authorisations. Regarding the first issue, the author finds that the law is deliberately ambiguous, as it neither rejects nor allows second medical use inventions. Regarding the second issue, Vietnam’s newly amended law in 2022 has arguably adopted a unique form of compensation: it waives the patent maintenance fees instead of extending the patent term. The paper concludes that because of the country’s sluggish local industry as well as its legislators’ struggle to keep pace with increasingly changing IP standards in the new FTAs, language ambiguity and lip service have become Vietnam’s weapons of choice.