bluuebunny/crossref_metadata_2025_split huggingface dataset:
HelperFriend, a Serious Game for Promoting Healthy Lifestyle Behaviors in Children: Design and Pilot Study
Authors: Espinosa-Curiel Ismael Edrein , Pozas-Bogarin Edgar Efrén , Hernández-Arvizu Maryleidi , Navarro-Jiménez Maria Elena , Delgado-Pérez Edwin Emeth , Martínez-Miranda Juan , Pérez-Espinosa Humberto 
Published: May 2022

Background
The use of health games is a promising strategy for educating and promoting healthy lifestyle behaviors among children.

Objective
We aimed to describe the design and development of a serious game, called HelperFriend, and evaluate its feasibility, acceptability, and preliminary effects in children in a pilot study. HelperFriend is a vicarious experiential video game designed to promote 3 lifestyle behaviors among young children: physical activity, healthy eating, and socioemotional wellness.

Methods
Participants aged 8 to 11 years were recruited from an elementary school and randomized to receive a healthy lifestyle behavior educational talk (control) or play six 30-minute sessions with HelperFriend (intervention). Assessments were conducted at baseline (T0) and after the intervention (ie, 4 weeks) (T1). The primary outcome was gain in knowledge. The secondary outcomes were intention to conduct healthy behaviors, dietary intake, and player satisfaction.

Results
Knowledge scores of intervention group participants increased from T0 to T1 for physical activity (t14=2.01, P=.03), healthy eating (t14=3.14, P=.003), and socioemotional wellness (t14=2.75, P=.008). In addition, from T0 to T1, the intervention group improved their intention to perform physical activity (t14=2.82, P=.006), healthy eating (t14=3.44, P=.002), and socioemotional wellness (t14=2.65, P=.009); and there was a reduction in their intake of 13 unhealthy foods. HelperFriend was well received by intervention group.

Conclusions
HelperFriend appears to be feasible and acceptable for young children. In addition, this game seems to be a viable tool to help improve the knowledge, the intention to conduct healthy behaviors, and the dietary intake of children; however, a well-powered randomized controlled trial is needed to prove the efficacy of HelperFriend.
Acceptability, Adaptability, and Feasibility of a Novel Computer-Based Virtual Counselor–Delivered Alcohol Intervention: Focus Group and In-depth Interview Study Among Adults With HIV or Tuberculosis in Indian Clinical Settings
Authors: Suryavanshi Nishi , Dhumal Gauri , Cox Samyra R , Sangle Shashikala , DeLuca Andrea , Santre Manjeet , Gupta Amita , Chander Geetanjali , Hutton Heidi 
Published: May 2022

Background
Unhealthy alcohol use is associated with increased morbidity and mortality among persons with HIV and tuberculosis (TB). Computer-based interventions (CBIs) can reduce unhealthy alcohol use, are scalable, and may improve outcomes among patients with HIV or TB.

Objective
We assessed the acceptability, adaptability, and feasibility of a novel CBI for alcohol reduction in HIV and TB clinical settings in Pune, India.

Methods
We conducted 10 in-depth interviews with persons with alcohol use disorder (AUD): TB (6/10), HIV (2/10), or HIV-TB co-infected (1/10) selected using convenience sampling method, no HIV or TB disease (1/10), 1 focus group with members of Alcoholics Anonymous (AA; n=12), and 2 focus groups with health care providers (HCPs) from a tertiary care hospital (n=22). All participants reviewed and provided feedback on a CBI for AUD delivered by a 3D virtual counselor. Qualitative data were analyzed using structured framework analysis.

Results
The majority (9/10) of in-depth interview respondents were male, with median age 42 (IQR 38-45) years. AA focus group participants were all male (12/12), and HCP focus group participants were predominantly female (n=15). Feedback was organized into 3 domains: (1) virtual counselor acceptability, (2) intervention adaptability, and (3) feasibility of the CBI intervention in clinic settings. Overall, in-depth interview participants found the virtual counselor to be acceptable and felt comfortable honestly answering alcohol-related questions. All focus group participants preferred a human virtual counselor to an animal virtual counselor so as to potentially increase CBI engagement. Additionally, interaction with a live human counselor would further enhance the program’s effectiveness by providing more flexible interaction. HCP focus group participants noted the importance of adding information on the effects of alcohol on HIV and TB outcomes because patients were not viewed as appreciating these linkages. For local adaptation, more information on types of alcoholic drinks, additional drinking triggers, motivators, and activities to substitute for drinking alcohol were suggested by all focus group participants. Intervention duration (about 20 minutes) and pace were deemed appropriate. HCPs reported that the CBI provides systematic, standardized counseling. All focus group and in-depth interview participants reported that the CBI could be implemented in Indian clinical settings with assistance from HIV or TB program staff.

Conclusions
With cultural tailoring to patients with HIV and TB in Indian clinical care settings, a virtual counselor–delivered alcohol intervention is acceptable and appears feasible to implement, particularly if coupled with person-delivered counseling.
Association of Phosphate-Containing versus Phosphate-Free Solutions on Ventilator Days in Patients Requiring Continuous Kidney Replacement Therapy
Authors: Thompson Bastin Melissa L. , Stromberg Arnold J. , Nerusu Sethabhisha N. , Liu Lucas J. , Mayer Kirby P. , Liu Kathleen D. , Bagshaw Sean M. , Wald Ron , Morris Peter E. , Neyra Javier A. 
Published: May 2022

Background and objectives
Hypophosphatemia is commonly observed in patients receiving continuous KRT. Patients who develop hypophosphatemia may be at risk of respiratory and neuromuscular dysfunction and therefore subject to prolongation of ventilator support. We evaluated the association of phosphate-containing versus phosphate-free continuous KRT solutions with ventilator dependence in critically ill patients receiving continuous KRT.

Design, setting, participants, & measurements
Our study was a single-center, retrospective, pre-post cohort study of adult patients receiving continuous KRT and mechanical ventilation during their intensive care unit stay. Zero-inflated negative binomial regression with and without propensity score matching was used to model our primary outcome: ventilator-free days at 28 days. Intensive care unit and hospital lengths of stay as well as hospital mortality were analyzed with a t test or a chi-squared test, as appropriate.

Results
We identified 992 eligible patients, of whom 649 (65%) received phosphate-containing solutions and 343 (35%) received phosphate-free solutions. In multivariable models, patients receiving phosphate-containing continuous KRT solutions had 12% (95% confidence interval, 0.17 to 0.47) more ventilator-free days at 28 days. Patients exposed to phosphate-containing versus phosphate-free solutions had 17% (95% confidence interval, −0.08 to −0.30) fewer days in the intensive care unit and 20% (95% confidence interval, − 0.12 to −0.32) fewer days in the hospital. Concordant results were observed for ventilator-free days at 28 days in the propensity score matched analysis. There was no difference in hospital mortality between the groups.

Conclusions
The use of phosphate-containing versus phosphate-free continuous KRT solutions was independently associated with fewer ventilator days and shorter stay in the intensive care unit.
GWAS of Hematuria
Authors: Gagliano Taliun Sarah A. , Sulem Patrick , Sveinbjornsson Gardar , Gudbjartsson Daniel F. , Stefansson Kari , Paterson Andrew D. , Barua Moumita 
Published: May 2022

Background and objectives
Glomerular hematuria has varied causes but can have a genetic basis, including Alport syndrome and IgA nephropathy.

Design, setting, participants, & measurements
We used summary statistics to identify genetic variants associated with hematuria in White British UK Biobank participants. Individuals with glomerular hematuria were enriched by excluding participants with genitourinary conditions. A strongly associated locus on chromosome 2 (COL4A4-COL4A3) was identified. The region was reimputed using the Trans-Omics for Precision Medicine Program followed by sequential rounds of regional conditional analysis, conditioning on previous genetic signals. Similarly, we applied conditional analysis to identify independent variants in the MHC region on chromosome 6 using imputed HLA haplotypes.

Results
In total, 16,866 hematuria cases and 391,420 controls were included. Cases had higher urinary albumin-creatinine compared with controls (women: 13.01 mg/g [8.05–21.33] versus 12.12 mg/g [7.61–19.29]; P<0.001; men: 8.85 mg/g [5.66–16.19] versus 7.52 mg/g [5.04–12.39]; P<0.001) and lower eGFR (women: 88±14 versus 90±13 ml/min per 1.72 m2; P<0.001; men: 87±15 versus 90±13 ml/min per 1.72 m2; P<0.001), supporting enrichment of glomerular hematuria. Variants at six loci (PDPN, COL4A4-COL4A3, HLA-B, SORL1, PLLP, and TGFB1) met genome-wide significance (P<5E-8). At chromosome 2, COL4A4 p.Ser969X (rs35138315; minor allele frequency=0.00035; P<7.95E-35; odds ratio, 87.3; 95% confidence interval, 47.9 to 159.0) had the most significant association, and two variants in the locus remained associated with hematuria after conditioning for this variant: COL4A3 p.Gly695Arg (rs200287952; minor allele frequency=0.00021; P<2.16E-7; odds ratio, 45.5; 95% confidence interval, 11.8 to 168.0) and a common COL4A4 intron 25 variant (not previously reported; rs58261427; minor allele frequency=0.214; P<2.00E-9; odds ratio, 1.09; 95% confidence interval, 1.06 to 1.12). Of the HLA haplotypes, HLA-B (*0801; minor allele frequency=0.14; P<4.41E-24; odds ratio, 0.84; 95% confidence interval, 0.82 to 0.88) displayed the most statistically significant association. For remaining loci, we identified three novel associations, which were replicated in the deCODE dataset for dipstick hematuria (nearest genes: PDPN, SORL1, and PLLP).

Conclusions
Our study identifies six loci associated with hematuria, including independent variants in COL4A4-COL4A3 and HLA-B. Additionally, three novel loci are reported, including an association with an intronic variant in PDPN expressed in the podocyte.

Podcast
This article contains a podcast at https://www.asn-online.org/media/podcast/CJASN/2022_04_26_CJN13711021.mp3
Absorption of grapiprant in red-tailed hawks (Buteo jamaicensis) is decreased when administered with food
Authors: Rodriguez Paula , Paul-Murphy Joanne R. , Knych Heather K. , Drazenovich Tracy L. , Hawkins Michelle G. 
Published: May 2022

Abstract

OBJECTIVE
Describe the pharmacokinetics of grapiprant administered orally with food to red-tailed hawks (RTHAs; Buteo jamaicensis) and compare the results with previously described grapiprant pharmacokinetics administered without food in this species.

ANIMALS
6 healthy adult RTHA (3 males, 3 females) under human care.

PROCEDURES
A single dose of grapiprant (30 mg/kg) was given orally to RTHAs, followed by force-feeding. Blood samples were obtained at 14 time points for 120 hours postgrapiprant administration. Plasma concentrations of grapiprant were measured via tandem liquid chromatography-mass spectrometry. Nonparametric superimposition using pharmacokinetic modeling software used plasma concentrations to calculate simulations of grapiprant plasma concentrations for 30 mg/kg administered orally with food every 12 hours.

RESULTS
The arithmetic mean maximum plasma concentration was 405.8 ng/mL, time to maximum plasma concentration was 16 hours, and harmonic mean terminal half-life was 15.6 hours. Simulations determined 30 mg/kg every 12 hours could attain minimum effective concentrations (> 164 ng/mL) reported in dogs for a sustained period of approximately 20 hours.

CLINICAL RELEVANCE
Grapiprant plasma concentrations were achieved above the canine therapeutic concentrations within 16 hours postmedication. Mean concentrations were maintained for approximately 20 hours. Simulations support a dosing frequency of 12-hour intervals with food reaching minimum effective concentrations established for canines, although it is unknown whether these plasma concentrations are therapeutic for birds. Bioaccumulation was not noted on simulations secondary to increased grapiprant administration. Further research including multidose assessments at this current dose with food, in vitro pharmacological characterization, and pharmacodynamic studies in this species are warranted.
How effective are hiring subsidies in reducing long-term unemployment among prime-aged jobseekers? Evidence from Belgium
Authors: Desiere Sam , Cockx Bart 
Published: May 2022

Abstract
Hiring subsidies are widely used to create (stable) employment for the long-term unemployed. This paper exploits the abolition of a hiring subsidy targeted at long-term unemployed jobseekers older than 45 years of age in Belgium to evaluate its effectiveness in the short and medium run. Based on a triple-difference methodology, the hiring subsidy is shown to increase the job-finding rate by 13% without any evidence of spillover effects. This effect is driven by a positive effect on individuals with at least a bachelor's degree. However, the hiring subsidy mainly creates temporary short-lived employment: eligible jobseekers are not more likely to find employment that lasts at least 12 consecutive months compared with ineligible jobseekers.
Effect of feeding of 10 % prefermented feed on fatty acid profile and oxidation changes in chicken breast meat
Authors: Bartkovský Martin , Marcinčáková Dana , Makiš Andrej , Klempová Tatiana , Semjon Boris , Roba Pavol , Marcinčák Slavomír 
Published: May 2022

Abstract
The aim of this work was to evaluate the effect of addition of 10 % fermented feed (FF) into commercial broiler feed on fatty acid profile, chemical composition and oxidative stability of chicken breast meat fat. FF was prepared by the process of fungal solid-state fermentation. Application of FF into the commercial feed mixtures resulted in increased content of gamma-linolenic and oleic acid in broiler breast meat (P < 0.05). Oxidative stability of meat fat was significantly higher in experimental broilers group fed diet with the addition of 10% FF (P < 0,05) after storage period of samples for seven days at temperature of 4 °C.
Endovascular management of iatrogenic vertebro-vertebral fistula: Black Swan event in C2 pedicle screw
Authors: Chaturvedi Jitender , Sudhakar P. Venkata , Gupta Mohit , Goyal Nishant , Mudgal Shiv Kumar , Gupta Priyanka , Burathoki Sandeep 
Published: May 2022

Background:
Vertebro-vertebral fistulas (VVF) are rare. Anatomically, they consist of an arteriovenous fistula, a direct pathological communication between vertebral veins (including the epidural vertebral venous plexus) and extradural vertebral artery. The various etiologies include trauma, iatrogenic, or spontaneous (e.g., NF-1 or Ehlers Danlos Syndrome). The clinical presentation may include acute/delayed onset of radiculopathy and/or myelopathy. They may further be characterized by the delayed onset hearing loss to tinnitus and/or the sensation of water in the ear.

Case Description:
We report successful endovascular management for iatrogenic VVF in a 37-year-old female who was diagnosed with an odontoid fracture (Anderson type IIC). She underwent a posterior C1 lateral masses to C2 pedicle/laminar screw fixation. An intraoperative vertebro-vertebral fistulas (VVF) was recognized during the procedure and it was managed successfully with percutaneous transarterial endovascular coiling.

Conclusion:
Iatrogenic VVF should immediately be suspected when the implant trajectory goes slightly off track during a C1-2 fixation. Immediate postoperative DSA and MRI are advisable, irrespective of whether the patient is symptomatic. These lesions are best managed with endovascular coiling with or without detachable balloons.
Preoperative hypoalbuminemia and dialysis increase morbidity/mortality after spine surgery for primary pyogenic spinal infections (ACS-NSQIP Study)
Authors: Camino-Willhuber Gaston , Franklin Austin , Rosecrance Katherine , Oyadomari Sarah , Chan Justin , Holc Fernando , Hashmi Sohaib , Oh Michael , Bhatia Nitin , Emmerich Juan , Lee Yu-Po 
Published: May 2022

Background:
We analyzed the role of hypoalbuminemia, dialysis, and other risk factors that increase morbidity/ mortality following surgery for primary pyogenic spinal infections (PSIs). The American College of Surgeons’ National Surgical Quality Improvement Program (ACS-NSQIP) that included 627 patients was utilized as our database.

Methods:
Primary spinal surgery for spondylodiscitis was evaluated in a ACS-NSQIP database involving 627 patients between 2010 and 2019. Outcome assessment included evaluation of 30-day postoperative morbidity, and mortality rates.

Results:
Within 30 postoperative days, complications occurred in 14.6% (92/627) of patients; 59 (9.4%) required readmission, and 39 (6.2%) required additional surgery. The most common complications were: wound infections, pneumonia, septic shock, and death (1.8%). Hypoalbuminemia (i.e., significantly associated with unplanned readmission and reoperation), and dialysis were the two major risk factors contributing to increased perioperative morbidity and mortality.

Conclusion:
Among 627 ACS-NSQIP patients undergoing primary surgery for PSIs, hypoalbuminemia and dialysis were associated with higher risks of major perioperative morbidity (i.e., within 30 postoperative days – mostly readmissions and reoperations) and mortality.
Langues et métalangages : verbe et prédication chez Heymann Steinthal
Authors: Samain Didier 
Published: May 2022

Héritier proclamé de Humboldt et initiateur avec Moritz Lazarus
(1824-1903) de la Völkerpsychologie, Heymann Steinthal (1823-1899) est traditionnellement considéré comme un représentant du courant «psychologique» en linguistique. L’un de ses premiers ouvrages (1855), qui multiplie les exemples de non concordance entre la «logique» et la «grammaire», se veut en effet une attaque en règle contre le «logicisme» qu’il impute à Becker et à la grammaire générale, en considérant notamment la prédication comme une propriété quasiment triviale (non spécifiquement grammaticale) du langage. Toutefois le sens de ces appellations n’est pas évident et les choses sont moins simples qu’il y paraît, car Steinthal emprunte en fait autant à ses ennemis déclarés qu’à Humboldt. Plusieurs faits méritent ici d’être soulignés. Premièrement, la généralisation qu’il fait subir à certains concepts classiques, et notamment à celui de prédicat, ce qui le conduit à une conception des relations dites «logiques» proche de celle des grammaires dépendancielles. Deuxièmement, le fait que la spécificité du plan grammatical soit définie, par contraste, dans le cadre d’une typologie basée sur le topos humboldtien du dynamisme de la phrase indo-européenne. Ces deux points, qui caractérisent la Mischsyntax un peu particulière à laquelle aboutit Steinthal, suggèrent qu’il n’y a pas de discontinuité tranchée entre théorie classique du jugement et grammaire dépendancielle. Ils posent aussi des questions épistémologiques plus générales, concernant notamment le lien unissant les objets empiriques (ici les langues) et les métalangages utilisés pour les décrire.
Sądownictwo administracyjne w województwie śląskim w latach 1922-1939
Authors: Naworski Zbigniew 
Published: May 2022

Artykuł składa się z trzech części. Pierwsza stanowiąca krótki wstęp przedstawia drogę do powstania województwa śląskiego w II RP, zarówno jego części poaustriackiej jak i popruskiej. Część druga charakteryzuje przejęcie wymiaru sprawiedliwość w b. dzielnicy pruskiej, co prawda nie dotyczyło to bezpośrednio Górnego Śląska, ale rozwiązania zastosowane w Wielkopolsce i Pomorzu zostały przeniesione w swoim zasadniczym zrębie na Górny Śląsk; krótko został też przedstawiony system sądownictwa administracyjnego obowiązujący na tym terenie przed odzyskaniem niepodległości. Część trzecia – zasadnicza – omawia budowę sądownictwa administracyjnego w województwie śląskim. Poza sądownictwem ogólnoadministracyjnym porzedstawiona została też problematyka administracyjnego postępowania spornego w sprawach górniczych. Całość kończy kilka uwag na temat języka urzędowego w postępowaniu przed śląskimi sądami administracyjnymi.
EL DERECHO DEL CONSUMIDOR Y SUS EFECTOS EN EL DERECHO CIVIL FRENTE A LA CONTRATACION DE CONSUMO EN EL MERCADO
Authors: Durand Carrión Julio Baltazar 
Published: May 2022

El fenómeno de la producción industrial, la anonimización y despersonalización de los proveedores, la masificación de los consumidores y la proliferación de los contratos por adhesión, han dado lugar a la “Contratación de Consumo” y al crecer el comercio, obviamente las normas clásicas del Derecho Privado incorporadas en los códigos civiles de base romanista el Código Civil e influencia napoleónica , sin duda resultan ya insuficientes para regular las efectos jurídicos derivados de este tipo de contratos, en un mercado como el de hoy lleno de presiones crecientes y extendidas. Por lo tanto, podemos establecer que el Derecho del Consumidor es una disciplina singular, especializada y con cierta autonomía que no se ubica ni en el Derecho Privado, ni en el Derecho Comercial, ni el Derecho Civil, sino que constituiría una disciplina de carácter interdisciplinario y que está fortalecida de nuevos conceptos y que tiene además notas características importantes. En este sentido el Derecho del Consumidor constituye un sistema global de normas, principios, instituciones e instrumentos consagrados por el ordenamiento jurídico a favor del consumidor para garantizar en el mercado una posición de equilibrio con los empresarios proveedores, en una relación de consumo y como destinatario final de los bienes y servicios adquiridos.
¿RESPONSABILIDAD PENAL O ADMINISTRATIVA DE LA PERSONA JURÍDICA?
Authors: Carrión Díaz Juan Elías 
Published: May 2022

La responsabilidad de las personas jurídicas en el Derecho penal tiene un tratamiento de reciente data en el Perú. En este estudio el autor analiza la responsabilidad penal y administrativa de las personas jurídicas teniendo en consideración el Decreto legislativo Nº 30424. En la evaluación efectuada se plantea por qué las personas jurídicas no cumplen con algunos elementos que configuran la estructura del delito.
REFERÉNDUM COMO RESPUESTA A LA CRISIS DE REPRESENTATIVIDAD EN EL PERÚ
Authors: Miró Quesada Rada Francisco 
Published: May 2022

El artículo aborda, primero desde una perspectiva sistemática, la configuración jurídico-constitucional del referéndum en el Perú. A continuación, se analiza su empleo como una herramienta política durante la crisis política que viene atravesando nuestro país.
Referéndum - crisis de la democracia representativa en el Perú - política peruana
PLURALISMO JURÍDICO, DERECHO INDÍGENA Y COLONIALIDAD JURÍDICA
Authors: Garzón López Pedro 
Published: May 2022

En este artículo se hace un esbozo sobre la “colonialidad jurídica” siguiendo algunas líneas teóricas del pensamiento decolonial latinoamericano a fin de analizar los límites del pluralismo jurídico en el contexto de los actuales Estados coloniales. Para ello, nos basamos en el derecho indígena para tratar de explicar la dificultad de lograr una relación equitativa entre dos sistemas jurídicos diferentes que conviven en un contexto de subordinación colonial. Cuestionar el derecho estatal más allá del derecho, implica desvelar la colonialidad del poder que subyace en la trilogía moderna y fundamento del monismo jurídico: Estado/soberanía/derecho.Pluralismo jurídico - colonialidad jurídica - colonialidad del poder - derecho, soberanía y pueblos indígenas