bluuebunny/crossref_metadata_2025_split huggingface dataset:
Detection and Co-occurrence of kdr (F1534C and S989P) Mutations in Multiple Insecticides Resistant Aedes aegypti (Diptera: Culicidae) in Nigeria
Authors: Fagbohun Ifeoluwa Kayode , Oyeniyi Tolulope Amos , Idowu Emmanuel Taiwo , Nwanya Oge , Okonkwo Felix , Adesalu Kemi O , Jimoh Romoke T , Oladosu Yusuff , Otubanjo Olubunmi Adetoro , Adeogun Adedapo O 
Published: August 2022

Abstract
The outbreak of yellow fever virus transmitted by Aedes aegypti has been of major concern in Nigeria, this mosquito also transmits several other arboviruses globally. The control of many vectors of mosquito-borne diseases relies heavily on the use of insecticides. Therefore, constant monitoring of insecticide resistance status and associated mechanisms is crucial within the local mosquito population. Here, we determined the resistance profile of adult Ae. aegypti from Majidun and Oke Ota communities, Ikorodu Local Government Area of Lagos State, Nigeria to different classes of insecticides using WHO procedures. The resistant phenotypes of Ae. aegypti were screened for the presence of kdr mutations F1534C, S989P, and V1016G, which have been implicated in insecticide resistance in yellow fever vectors. A high level of resistance to DDT and pyrethroids was recorded in Ae. aegypti in this study, although possible resistance to deltamethrin, one of the pyrethroids was reported in one of the locations. Resistance to bendiocarb was recorded in the Majidun community while Ae. aegypti in both locations were susceptible to malathion. The presence of F1534C mutation associated with DDT and deltamethrin resistance in Ae. aegypti population, and the presence of S989P mutation were detected singly and in co-occurrence with F1534C for the first time in Africa, while V1016G mutation was not detected in this study. The role of these mutations in resistance phenotype expressed in Ae. aegypti in larger populations needs to be established.
Body Mass Index Trajectories, Weight Gain, and Risks of Liver and Biliary Tract Cancers
Authors: Yang Wanshui , Zeng Xufen , Petrick Jessica L , Danford Christopher J , Florio Andrea A , Lu Bing , Nan Hongmei , Ma Jiantao , Wang Liang , Zeng Hongmei , Sudenga Staci L , Campbell Peter T , Giovannucci Edward , McGlynn Katherine A , Zhang Xuehong 
Published: August 2022

Abstract

Background
Little is known about the role of early obesity or weight change during adulthood in the development of liver cancer and biliary tract cancer (BTC).

Methods
We investigated the associations of body mass index (BMI) and weight trajectories with the risk of liver cancer and BTC in the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial. BMI was self-reported at ages 20 years and 50 years and at enrollment. BMI trajectories were determined using latent class growth models. Cox regression was used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs).

Results
During a median follow-up of 15.9 years among 138 922 participants, 170 liver cancer and 143 BTC cases were identified. Compared with those whose BMI did not exceed 25 kg/m2, participants with BMI exceeding 25 kg/m2 at age 20 years had increased risks of liver cancer (HR = 2.03, 95% CI = 1.26 to 3.28) and BTC (HR = 1.99, 95% CI = 1.16 to 3.39). Compared with participants maintaining normal BMI until enrollment, trajectory of normal weight at age 20 years to obesity at enrollment was associated with increased risk for liver cancer (HR = 2.50, 95% CI = 1.55 to 4.04) and BTC (HR = 1.83, 95% CI = 1.03 to 3.22). Compared with adults with stable weight (±5 kg) between age 20 years and 50 years, weight gain of 20 kg and greater between ages 20 years and 50 years had higher hazard ratios of 2.24 (95% CI = 1.40 to 3.58) for liver cancer and 1.86 (95% CI = 1.12 to 3.09) for BTC.

Conclusions
Being overweight and/or obese at age 20 years and BMI trajectories that result in being overweight and/or obese may increase risk for both liver cancer and BTC.
Are non-native speakers the drivers of morphological simplification? A Wug experiment on the Dutch past tense system
Authors: De Smet Isabeau , Rosseel Laura , Van de Velde Freek 
Published: August 2022

AbstractIt has often been suggested that there is an inverse correlation between the number of adult non-native speakers in a language and its morphological complexity. Secluded languages often show more complex morphology, while high-contact languages go through more severe simplifications throughout the ages. One such simplification linked to language contact is the regularization of the Germanic past tense. Yet, a Wug task on the English past tense system by Cuskley et al. (2015) showed that non-native speakers tend to use the irregular past tense even more than native speakers. In this article, we replicate the Wug experiment for Dutch. Our results show similar evidence for a higher rate of irregularization across non-native speakers. Furthermore, we do not find any other simplification strategies among non-native speakers. Though caution is warranted, these converging results may suggest that non-native speakers are not the drivers of morphological simplification.
A case of seronegative primary Sjögren’s syndrome complicated by Takayasu arteritis in a Japanese girl
Authors: Yamanishi Shingo , Tanabe Yujiro , Watanabe Makoto , Narazaki Hidehiko , Igarashi Toru , Fukazawa Ryuji , Isobe Mitsuaki , Itoh Yasuhiko 
Published: August 2022

ABSTRACT
In paediatric primary Sjögren’s syndrome (SS), the initial symptoms manifest systemically, such as fever, general fatigue, and lymphadenopathy, rather than sicca symptoms. Most children with primary SS have autoantibodies, such as antinuclear, anti-Ro/SS-A, and/or anti-La/SS-B antibodies; however, some patients are seronegative. Similar to paediatric patients with primary SS, those with Takayasu arteritis (TAK) initially only present constitutional symptoms, making it difficult to suspect, unless characteristic features are present. To our knowledge, there have been no reports of the coexistence of both diseases in children. We present a rare case of seronegative SS complicated by TAK in a 9-year-old girl who presented with a persistent low-grade fever, general fatigue, cervical lymphadenopathy, and multiple caries. Although blood examination revealed all autoantibodies to be negative, a lip biopsy revealed lymphocytic sialadenitis, and a sialoscintigraphy indicated hypofunctional salivary glands, leading to the diagnosis of seronegative SS. The patient was treated with low-dose glucocorticoid and immunosuppressant administration to inhibit persistent inflammation and the progression of salivary gland dysfunction; although the symptoms resolved, inflammatory markers remained elevated. When the patient was 14 years old, cervical bruits were incidentally found, and TAK was suspected based on cervical ultrasonography and magnetic resonance angiography findings. 18F-fluorodeoxyglucose-positron emission tomography/computed tomography results demonstrated increased fluorodeoxyglucose accumulation from the ascending to descending aorta. Therefore, she was diagnosed with SS complicated by TAK, which is rare. Aortitis should be suspected when the cause of persistent inflammation cannot be ascertained in patients with SS.
Five cases of seronegative persistent inflammatory monoarthritis improved with biological therapy
Authors: Izumiyama Takuya , Mori Yu , Hamada Soshi , Kurishima Hiroaki , Mori Naoko , Aizawa Toshimi 
Published: August 2022

ABSTRACT
Persistent inflammatory monoarthritis is defined as inflammation of one joint that continues for longer than 3 months. Most cases remain as nonspecific arthritis after several years. Persistent inflammatory monoarthritis is difficult to diagnose and treat in the early stage because there are no criteria for diagnosis and treatment. We report five seronegative persistent inflammatory monoarthritis cases that affected the left knee, right knee, left knee, left ankle, and right knee. All patients underwent joint punctures; two patients received steroid injections in the affected joint. The bacterial and mycobacterial culture were negative in all patients. Two patients received oral steroids, and two patients were administered nonsteroidal anti-inflammatory drugs; however, their symptoms did not improve, and one patient experienced progression of joint destruction. We investigated the usefulness of biological disease-modifying antirheumatic drugs for the treatment of seronegative persistent inflammatory monoarthritis. We obtained a remarkable improvement effect and prevented the advance of joint destruction.
An academic survey on theoretical foundations, common assumptions and the current state of consciousness science
Authors: Francken Jolien C , Beerendonk Lola , Molenaar Dylan , Fahrenfort Johannes J , Kiverstein Julian D , Seth Anil K , van Gaal Simon 
Published: August 2022

Abstract
We report the results of an academic survey into the theoretical and methodological foundations, common assumptions, and the current state of the field of consciousness research. The survey consisted of 22 questions and was distributed on two different occasions of the annual meeting of the Association of the Scientific Study of Consciousness (2018 and 2019). We examined responses from 166 consciousness researchers with different backgrounds (e.g. philosophy, neuroscience, psychology, and computer science) and at various stages of their careers (e.g. junior/senior faculty and graduate/undergraduate students). The results reveal that there remains considerable discussion and debate between the surveyed researchers about the definition of consciousness and the way it should be studied. To highlight a few observations, a majority of respondents believe that machines could have consciousness, that consciousness is a gradual phenomenon in the animal kingdom, and that unconscious processing is extensive, encompassing both low-level and high-level cognitive functions. Further, we show which theories of consciousness are currently considered most promising by respondents and how supposedly different theories cluster together, which dependent measures are considered best to index the presence or absence of consciousness, and which neural measures are thought to be the most likely signatures of consciousness. These findings provide us with a snapshot of the current views of researchers in the field and may therefore help prioritize research and theoretical approaches to foster progress.
European Association of Neuro-Oncology (EANO) guidelines for treatment of primary central nervous system lymphoma (PCNSL)
Authors: Hoang-Xuan Khê , Deckert Martina , Ferreri Andrés J M , Furtner Julia , Gallego Perez-Larraya Jaime , Henriksson Roger , Hottinger Andreas F , Kasenda Benjamin , Lefranc Florence , Lossos Alexander , McBain Catherine , Preusser Matthias , Roth Patrick , Rudà Roberta , Schlegel Uwe , Soffietti Riccardo , Soussain Carole , Taphoorn Martin J B , Touitou Valérie , Weller Michael , Bromberg Jacoline E C 
Published: August 2022

Abstract
The management of primary central nervous system (PCNSL) is one of the most controversial topics in neuro-oncology because of the complexity of the disease and the limited number of controlled studies available. In 2021, given recent advances and the publication of practice-changing randomized trials, the European Association of Neuro-Oncology (EANO) created a multidisciplinary task force to update the previously published evidence-based guidelines for immunocompetent adult patients with PCNSL and added a section on immunosuppressed patients. The guideline provides consensus considerations and recommendations for the treatment of PCNSL, including intraocular manifestations and specific management of the elderly. The main changes from the previous guideline include strengthened evidence for the consolidation with ASCT in first-line treatment, prospectively assessed chemotherapy combinations for both young and elderly patients, clarification of the role of rituximab even though the data remain inconclusive, of the role of new agents, and the incorporation of immunosuppressed patients and primary ocular lymphoma. The guideline should aid the clinicians in everyday practice and decision making and serve as a basis for future research in the field.
Gender and Tourism in the (Very) Long Nineteenth Century
Authors: Morgan Cecilia 
Published: August 2022

Abstract
The intersections of gender, travel, and tourism have received much scholarly attention, particularly since the publication of Sara Mills’s Discourses of Differences and Mary Louise Pratt’s Imperial Eyes. The travel writings and tourist experiences of European and Anglo-American middle-class women have been prominent in the field. Although much attention has been paid to their imbrication in both class and imperial relations, the wide range of women’s travel writing, its multiple layers, and the varied locations from which it was written suggest that no one model of “feminization” can be applied to its analysis. Scholars also have pointed to the gendered nature of work at tourist sites, whether in the provision of hospitality, the creation of souvenirs, and the presence of female guides. The travels of Indigenous and racialized women also help complicate our understanding of nineteenth and early twentieth-century tourist “gazes.” Although less has been written about male tourists that deploys gender as a category of historical analysis, the existing scholarship that does so suggests possibilities for future work.
Colonial Tourism
Authors: Jennings Eric T. 
Published: August 2022

Abstract
Spanning all continents except for Antarctica, this entry seeks to uncover some of the trends and tropes of colonial tourism. It first considers definitions as well as unique and shared features of colonial travel. It ponders the scale of the phenomenon in the nineteenth and early twentieth centuries before analyzing the passage over to the colony, colonial cruises and colonial hunting expeditions. It then turns to power relations at imperial hill stations and spas. It takes on the question of indigenous tourism, tied in part to the rise of an expanding middle-class in a number of different colonial contexts. The entry then engages with armchair travel through colonial exhibits, as well as the issue of non-European imperial tourism. Finally, it discusses postcolonial breaks and continuities during and after the era of decolonization.
Tourism Development in Latin America and the Caribbean
Authors: Wood Andrew Grant 
Published: August 2022

Abstract
In considering the early history of tourism in Latin America and the Caribbean particular attention is paid here to the development of transport technologies, hospitality infrastructure, and economic-social relations. Significant national tourism industry growth in Mexico, the Caribbean, and South America is also discussed as well as, however briefly, the emergence of different kinds of travel practices and concerns about the larger negative social and environmental impact that tourism is generating.
Nudism
Authors: Harp Stephen L. 
Published: August 2022

Abstract
The twentieth century saw the emergence and development of nude tourism. Initially a return to nature to get exercise and restore health, mixed-sex public nudity increasingly became a variant of mass beach vacations after World War II. By the early twenty-first century, nudism had become widespread on European beaches, where most practitioners were Europeans or inhabitants of former European settler colonies. Today, a fine line separates nude tourism and sex tourism.
The final piece of the Triangle of U: Evolution of the tetraploid Brassica carinata genome
Authors: Yim Won Cheol , Swain Mia L , Ma Dongna , An Hong , Bird Kevin A , Curdie David D , Wang Samuel , Ham Hyun Don , Luzuriaga-Neira Agusto , Kirkwood Jay S , Hur Manhoi , Solomon Juan K Q , Harper Jeffrey F , Kosma Dylan K , Alvarez-Ponce David , Cushman John C , Edger Patrick P , Mason Annaliese S , Pires J Chris , Tang Haibao , Zhang Xingtan 
Published: August 2022

Abstract
Ethiopian mustard (Brassica carinata) is an ancient crop with remarkable stress resilience and a desirable seed fatty acid profile for biofuel uses. Brassica carinata is one of six Brassica species that share three major genomes from three diploid species (AA, BB, and CC) that spontaneously hybridized in a pairwise manner to form three allotetraploid species (AABB, AACC, and BBCC). Of the genomes of these species, that of B. carinata is the least understood. Here, we report a chromosome scale 1.31-Gbp genome assembly with 156.9-fold sequencing coverage for B. carinata, completing the reference genomes comprising the classic Triangle of U, a classical theory of the evolutionary relationships among these six species. Our assembly provides insights into the hybridization event that led to the current B. carinata genome and the genomic features that gave rise to the superior agronomic traits of B. carinata. Notably, we identified an expansion of transcription factor networks and agronomically important gene families. Completion of the Triangle of U comparative genomics platform has allowed us to examine the dynamics of polyploid evolution and the role of subgenome dominance in the domestication and continuing agronomic improvement of B. carinata and other Brassica species.
Clinical and therapeutic diversity in adult chronic nonbacterial osteomyelitis (CNO) of the sternocostoclavicular region: a meta-analysis
Authors: Leerling Anne T , Dekkers Olaf M , Appelman-Dijkstra Natasha M , Winter Elizabeth M 
Published: August 2022

Abstract

Objectives
Chronic nonbacterial osteomyelitis (CNO) is a rare inflammatory bone disease. The distinct CNO subtype that affects the anterior chest wall is descriptively named sternocostoclavicular hyperostosis (SCCH) and mainly occurs in adults. Literature on CNO/SCCH is scattered and lacks diagnostic and therapeutic consensus.

Methods
Systematic review and meta-analysis aiming to characterize clinical presentation and therapeutic modalities applied in adult CNO/SCCH patients. Untransformed numerical data and double-arcsine transformed proportional data were pooled in a random effects model in R-4.0.5; proportions were reported with 95% CI.

Results
Forty studies were included, containing data on 2030 and 642 patients for aim 1 and 2, respectively. A female predisposition (67%, 95% CI 60, 73) and major diagnostic delay (5 years 95% CI 3, 7) were noted. Clinical presentation included chest pain (89%, 95% CI 79, 96) and swelling (79%, 95% CI 62, 91). Patients suffered from pustulosis palmoplantaris (53%, 95% CI 37, 68), arthritis (24%, 95% CI 11, 39) and acne (8%, 95% CI 4, 13). Inflammatory markers were inconsistently elevated. Autoantibody and HLA-B27 prevalence was normal, and histopathology unspecific. Increased isotope uptake (99%, 95% CI 96, 100) was a consistent imaging finding. Among manifold treatments, pamidronate and biologicals yielded good response in 83%, 95% CI 60, 98 and 56%, 95% CI 26, 85, respectively.

Conclusion
CNO/SCCH literature proves heterogeneous regarding diagnostics and treatment. Timely diagnosis is challenging and mainly follows from increased isotope uptake on nuclear examination. Biopsies, autoantibodies and HLA status are non-contributory, and biochemical inflammation only variably detected. Based on reported data, bisphosphonates and biologicals seem reasonably effective, but due to limitations in design and heterogeneity between studies the precise magnitude of their effect is uncertain. Fundamentally, international consensus seems imperative to advance clinical care for CNO/SCCH.
ESTABLISHMENT OF THE IN VITRO DOSE–RESPONSE CALIBRATION CURVE FOR X-RAY-INDUCED MICRONUCLEI IN HUMAN LYMPHOCYTES
Authors: Meng Qian-Qian , Zhang Rui-Feng , Zhang Zhong-Xin , Yang Yi , Chai Dong-Liang , Yuan Ya-Yi , Ren Yue , Dong Juan-Cong , Dang Xu-Hong 
Published: August 2022

Abstract
The cytokinesis-block micronucleus assay has proven to be a reliable technique for biological dosimetry. This study aimed to establish the dose–response curve for X-ray-induced micronucleus. Peripheral blood samples from three healthy donors were irradiated with various doses and scoring criteria by the micronuclei (MN) in binucleated cells. The results showed that the frequency of MN increased with the elevation of radiation dose. CABAS and Dose Estimate software were used to fit the MN and dose into a linear quadratic model, and the results were compared. The linear and quadratic coefficients obtained by the two software were basically the same and were comparable with published curves of similar radiation quality and dose rates by other studies. The dose–response curve established in this study can be used as an alternative method for in vitro dose reconstruction and provides a reliable tool for biological dosimetry in accidental or occupational radiation exposures.
Evaluating the persistence and stability of a DNA-barcoded microbial system in a mock home environment
Authors: McDonald Nathan D , Rhea Katherine A , Davies John P , Zacharko Julie L , Berk Kimberly L , Buckley Patricia E 
Published: August 2022

Abstract
Recent advancements in engineered microbial systems capable of deployment in complex environments have enabled the creation of unique signatures for environmental forensics operations. These microbial systems must be robust, able to thrive in specific environments of interest and contain molecular signatures, enabling the detection of the community across conditions. Furthermore, these systems must balance biocontainment concerns with the stability and persistence required for environmental forensics. Here we evaluate the stability and persistence of a recently described microbial system composed of germination-deficient Bacillus subtilis and Saccharomyces cerevisiae spores containing nonredundant DNA barcodes in a controlled simulated home environment. These spore-based microbial communities were found to be persistent in the simulated environment across 30-day periods and across multiple surface types. To improve the repeatability and reproducibility in detecting the DNA barcodes, we evaluated several spore lysis and sampling processes paired with Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) -CRISPR-associated proteins (Cas) detection (Sherlock). Finally, having optimized the detectability of the spores, we demonstrate that we can detect the spores transferring across multiple material types. Together, we further demonstrate the utility of a recently described microbial forensics system and highlight the importance of independent validation and verification of synthetic biology tools and applications.
Graphical Abstract