bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hospital Service Quality and Patients’ satisfaction within Soddo Christian Hospital PLC, Walaitta Region, Southwestern Ethiopia
Authors: Providence Sibomana , Cissy Karungi , Sylvestre Munyengabe 
Published: October 2022

In this paper about Hospital service quality and patient satisfaction have been considered as significant factors for any Hospital that is looking forward to succeed, the research tested a service quality model SERVQUAL to measure patient’s satisfaction with the delivery of service. Five main dimensions of the service quality model SERVQUAL which were applied are tangibility, reliability, responsiveness, assurance and empathy. The model was applied to the customers who had previous experience from Soddo Christian Hospital. The purpose of this paper was to investigate the factors that contribute to customer satisfaction at Soddo Christian Hospital. The study helps to examine and understand the factors influenced in determining customer satisfaction. Usable samples of 250 questionnaires were collected out of 302 that were distributed to the patients. SPSS software was used to do reliability analysis and regression analysis. The findings showed that there is a significant relationship between contextual factors and customer satisfaction as the correlation coefficient of 0.730 indicate high correlation between responsiveness dimension and customer satisfaction. The analysis indicated that responsiveness of perceived quality have direct relationship with customer satisfaction compared to other contextual factors. Furthermore, this paper reports that customer satisfaction depend on service quality as there is statistical significance of the predictor hospital service quality (F5, 225= 52.395 and p<.000), has probability occurrence of by chance only of less than 0.001) this confirms that, there is statistical significance at 1% level between hospital service and patient satisfaction.
There is moderate positive significant relationship with patient satisfaction as the perceived correlations of four dimensions are: Tangibility (r = .635), Reliability (.r = .645), Assurance (r = .620) and Empathy (r = .622) respectively.
Quality of information in YouTube videos on prostate fusion biopsy
Authors: Aydogan Tahsin Batuhan 
Published: October 2022

Objective: The aim of this study is to evaluate the quality of videos on YouTube related to MRI-TRUS prostate fusion biopsy. Material and Methods: A YouTube search was made on March 16, 2022, for the videos related to “MRI-TRUS prostate fusion biopsy”. The first 70 videos were ranked during this study by choosing “relevance” as a criterion. Video content quality was evaluated using the internationally validated Journal of the American Medical Association Benchmark Score (JAMAS) and Global Quality Score (GQS). The researcher also developed MRI-TRUS Prostate Fusion Biopsy Scoring (MTPFBS) to evaluate videos’ technical content. The upload origin and length of video view count, like and dislike ratios, and video power indexes (VPI) were all evaluated. Results: Video content from academic center sources had significantly higher GQS scores than scientific meetings or private institution videos. Video content prepared by private institution sources had significantly lower MTPFBS and JAMA scores than other videos (p<0.05). According to the type of information, videos uploaded with voice and writing had significantly higher JAMAS and MTPFBS than voice alone (p<0.05). The length of videos showed a positive correlation with JAMA and MTPFBS. VPI and the number of likes showed a strong correlation. However, VPI or the number of likes did not correlate with GQS, JAMAS, and MTPFBS scores. Conclusion: Evaluated on YouTube, the MRI-TRUS prostate fusion biopsy videos were low quality. In that regard, videos prepared by specialists and academic centers should be standardized to transfer better quality information. According to current data, watching these video contents may not be recommended. Keywords: Multiparametric magnetic resonance imaging; prostate; internet
The efficacy of regional analgesia techniques in urological robotic surgeries: a retrospective clinical study
Authors: Coşarcan Sami Kaan , Doğan Alper Tunga , Kılıç Mert , Erçelen Ömür 
Published: October 2022

Objective: The advantages of robot-assisted surgery include shorter incisions, less postoperative pain, perioperative blood loss, and a faster return to daily functions. Thoracic epidural analgesia (TEA) provides highly satisfactory analgesia in abdominal surgery. However, its hypotensive effect, particularly in minimally invasive procedures, exceeds its contribution to rapid recovery. Fascial plane blocks may be more beneficial in that context. This study evaluated the effects of regional analgesia techniques in robotic prostatectomy, nephrectomy, and cystectomy operations. Material and Methods: Following IRB Ethics Committee approval (2021.467.IRB1.134), the records of patients who had undergone robotic prostatectomy, nephrectomy, and cystectomy surgeries were retrospectively reviewed between January 2018 and January 2022. Results: One hundred and forty patients with full documentation were included in this study. Various regional analgesia methods were used. Fascial plane blocks were seen to be used in addition to epidural analgesia. Transversus abdominis plane (TAP) and rectus sheath blocks exhibited satisfactory results in robotic prostate surgeries and TAP blocks in robotic nephrectomy operations. Conclusion: In robotic prostatectomy and nephrectomy operations, we recommend fascial plane blocks as the first-choice method for postoperative analgesia. Keywords: regional anesthesia, robotic surgery, radical prostatectomy, minimally invasive surgery, fascial plane blocks, recovery after surgery
The single-atom iron nanozyme mimicking peroxidase remodels energy metabolism and tumor immune landscape for synergistic chemodynamic therapy and photothermal therapy of triple-negative breast cancer
Authors: Qian Xiaojun , Shi Ronghua , Chen Jian , Wang Yong , Han Xinghua , Sun Yubei , Ling Cong , Wang Gang , Xu An-Wu , Pan Yueyin 
Published: October 2022

Chemotherapy, as one main strategy to relieve tumor progression, has a weak effect on triple-negative breast cancer (TNBC) chest wall metastasis. The development of near-infrared (NIR) light-responsive nanomaterials for chemodynamic therapy (CDT) and photothermal therapy (PTT) is a promising platform but still challenging in biomedicine. This study reports a peroxidase mimicking nanozyme (Fe-N-C SAzyme) against TNBC by CDT and PTT. Fe-N-C SAzyme generated reactive oxygen species (ROS) by decomposing H2O2 into hydroxyl radicals (•OH) and also induced light-to-heat conversion under the exposure of 808 nm laser irradiation. With these biological characteristics, the obtained Fe-N-C SAzymes displayed enhanced cell cytotoxicity and inhibition of cancer cell proliferation both in vitro and in vivo at a low dose of nanoagent and a moderate NIR laser power density. Besides, Fe-N-C nanoagent with its excellent ROS generation brought metabolic reprogramming of elevated glycolysis in tumor cells. In vivo experiments, when combined with PTT, the enhanced antitumor effect was found by the elimination of M-MDSC in tumor microenvironment. Fe-N-C SAzymes can serve as a new synergistic CDT and PTT nanoagent to simultaneously reprogram tumor metabolism and tumor microenvironment. It will provide prospects for chemodynamic/photothermal combined cancer therapy for TNBC chest wall metastasis based on the use of a single nanosystem.
Comparison of early osseointegration of non-thermal atmospheric plasma-functionalized/ SLActive titanium implant surfaces in beagle dogs
Authors: Long Li , Zhang Min , Gan Shuaiqi , Zheng Zheng , He Yanjin , Xu Jia , Fu Ruijie , Guo Qiang , Yu Deping , Chen Wenchuan 
Published: October 2022

Background: Hydrophilic dental implants are gaining increasing interest for their ability to accelerate bone formation. However, commercially available hydrophilic implants, such as SLActive™, have some major limitations due to their time-dependent biological aging and lower cost-effectiveness. The non-thermal atmospheric plasma (NTAP) treatment is a reliable way to gain a hydrophilic surface and enhance osseointegration. However, a few studies have been carried out to compare the osseointegration of NTAP-functionalized titanium implants and commercially available hydrophilic implants.Purpose: In this study, we compare the osseointegration abilities of the NTAP-functionalized titanium implant and Straumann SLActive.Material and methods: The NTAP effectiveness was examined using in vitro cell experiments. Then, six beagle dogs were included in the in vivo experiment. Straumann SLActive implants, SLA implants, and SLA implants treated with NTAP were implanted in the mandibular premolar area of dogs. After 2 w, 4 w, and 8 w, the animals were sacrificed and specimens were collected. Radiographic and histological analyses were used to measure osseointegration.Results: NTAP treatment accelerated the initial attachment and differentiation of MC3T3-E1 cells. In the in vivo experiment, bone parameters (e.g., BIC value and BV/TV) and volume of new bone of NTAP groups were close to those of the SLActive group. Additionally, although there was no statistical difference, the osseointegration of SLActive and NTAP groups was evidently superior to that of the SLA group.Conclusion: NTAP-functionalized implants enhanced cell interaction with material and subsequent bone formation. The osseointegration of the NTAP-functionalized implant was comparable to that of the SLActive implant at the early osseointegration stage.
Wrack placement to augment constructed dunes: A field investigation
Authors: Provost Leigh A. , Eisemann Eve R. , Anderson Carlton P. , Waldron Margaret C. B. 
Published: October 2022

Natural and nature-based features have become increasingly popular in recent years for several reasons including reduced costs and maintenance, sustainability, and ecological benefits. One such nature-based feature which contributes to coastal resiliency is dune systems. Extensive research shows that dune systems provide great value for coastal protection, with vegetation and belowground biomass emerging as crucial factors for dune stability. Alternative dune construction and dune maintenance methods are needed to improve the resilience and stability of these dune systems. Wrack, vegetation and macroalgae that naturally washes up along the coast, is often removed during routine beach maintenance, but could serve to increase dune biomass, sand trapping, and overall dune resiliency. This manuscript documents preliminary results following the placement of wrack along constructed dunes on the Mississippi mainland coast. Terrestrial lidar surveys were used to evaluate morphological responses of a 550 m stretch of the beach, with varying raking and wrack management practices implemented in designated sections. Elevation and volumetric change calculated from these data were compared across storm erosion and fair-weather recovery periods to quantify the potential benefits of utilizing natural wrack material in the dunes and reducing beach raking.
Comparison of conventional scoring systems to machine learning models for the prediction of major adverse cardiovascular events in patients undergoing coronary computed tomography angiography
Authors: Ghorashi Seyyed Mojtaba , Fazeli Amir , Hedayat Behnam , Mokhtari Hamid , Jalali Arash , Ahmadi Pooria , Chalian Hamid , Bragazzi Nicola Luigi , Shirani Shapour , Omidi Negar 
Published: October 2022

BackgroundThe study aims to compare the prognostic performance of conventional scoring systems to a machine learning (ML) model on coronary computed tomography angiography (CCTA) to discriminate between the patients with and without major adverse cardiovascular events (MACEs) and to find the most important contributing factor of MACE.Materials and methodsFrom November to December 2019, 500 of 1586 CCTA scans were included and analyzed, then six conventional scores were calculated for each participant, and seven ML models were designed. Our study endpoints were all-cause mortality, non-fatal myocardial infarction, late coronary revascularization, and hospitalization for unstable angina or heart failure. Score performance was assessed by area under the curve (AUC) analysis.ResultsOf 500 patients (mean age: 60 ± 10; 53.8% male subjects) referred for CCTA, 416 patients have met inclusion criteria, 46 patients with early (&lt;90 days) cardiac evaluation (due to the inability to clarify the reason for the assessment, deterioration of the symptoms vs. the CCTA result), and 38 patients because of missed follow-up were not enrolled in the final analysis. Forty-six patients (11.0%) developed MACE within 20.5 ± 7.9 months of follow-up. Compared to conventional scores, ML models showed better performance, except only one model which is eXtreme Gradient Boosting had lower performance than conventional scoring systems (AUC:0.824, 95% confidence interval (CI): 0.701–0.947). Between ML models, random forest, ensemble with generalized linear, and ensemble with naive Bayes were shown to have higher prognostic performance (AUC: 0.92, 95% CI: 0.85–0.99, AUC: 0.90, 95% CI: 0.81–0.98, and AUC: 0.89, 95% CI: 0.82–0.97), respectively. Coronary artery calcium score (CACS) had the highest correlation with MACE.ConclusionCompared to the conventional scoring system, ML models using CCTA scans show improved prognostic prediction for MACE. Anatomical features were more important than clinical characteristics.
Synergistic effect of myocardial injury and mid-regional proAdrenomedullin elevation in determining clinical outcomes of SARS-CoV-2 patients
Authors: Spoto Silvia , Mangiacapra Fabio , D’Avanzo Giorgio , Lemme Daniela , Bustos Guillén César , Abbate Antonio , Markley John Daniel , Sambuco Federica , Markley Roshanak , Fogolari Marta , Locorriere Luciana , Lupoi Domenica Marika , Battifoglia Giulia , Costantino Sebastiano , Ciccozzi Massimo , Angeletti Silvia 
Published: October 2022

ObjectiveCoronavirus disease 2019 (COVID-19) is a systemic disease induced by SARS-CoV-2 causing myocardial injury. To date, there are few data on the correlation between mid-regional proAdrenomedullin (MR-proADM) and myocardial injury. The aim of this study was to evaluate whether the association of myocardial injury and elevated mid-regional proAdrenomedullin values could predict mortality of SARS-CoV-2 patients, to offer the best management to COVID-19 patients.Materials and methodsAll patients hospitalized for SARS-CoV-2 infection at the COVID-19 Center of the Campus Bio-Medico of Rome University were included between October 2020 and March 2021 and were retrospectively analyzed. Myocardial injury was defined as rising and/or fall of cardiac hs Troponin I values with at least one value above the 99th percentile of the upper reference limit (≥15.6 ng/L in women and ≥34.2 ng/L in men). The primary outcome was 30-day mortality. Secondary outcomes were the comparison of MR-proADM, CRP, ferritin, and PCT as diagnostic and prognostic biomarkers of myocardial injury. Additionally, we analyzed the development of ARDS, the need for ICU transfer, and length of stay (LOS).ResultsA total of 161 patients were included in this study. Of these, 58 (36.0%) presented myocardial injury at admission. An MR-proADM value ≥ 1.19 nmol/L was defined as the optimal cut-off to identify patients with myocardial injury (sensitivity 81.0% and specificity 73.5%). A total of 121 patients (75.2%) developed ARDS, which was significantly more frequent among patients with myocardial injury (86.2 vs. 68.9%, p = 0.015). The overall 30-day mortality was 21%. Patients with myocardial injury presented significantly higher mortality compared to those without the same (46.6 vs. 6.8%, p &lt; 0.001). When dividing the entire study population into four groups, based on the presence of myocardial injury and MR-proADM values, those patients with both myocardial injury and MR-proADM ≥ 1.19 nmol/L presented the highest mortality (53.2%, p &lt; 0.001). The combination of myocardial injury and MR-proADM values ≥ 1.19 nmol/L was an independent predictor of death (OR = 7.82, 95% CI = 2.87–21.30; p &lt; 0.001).ConclusionThe study is focused on the correlation between myocardial injury and MR-proADM. Myocardial injury induced by SARS-CoV-2 is strongly associated with high MR-proADM values and mortality.
Stroke health management: Novel strategies for the prevention of recurrent ischemic stroke
Authors: Jiang Lili , Zhou Yu , Zhang Li , Wu Lingling , Shi Haibin , He Bin , Wang Yao , Liu Qianghui , Ji Xueli , Zhang Xintong , Jiang Lei , Sun Hao 
Published: October 2022

ObjectivesThe aim of the study was to assess the effect of the stroke health management model on the prognosis and recurrence of mild to moderate ischemic stroke, guided by the stroke health manager based on the patients' needs. In addition, up-to-date evidence of healthcare resource allocation, planning, and optimization is provided.MethodsThe current research was a retrospective, observational, single-center, history-controlled study with patients divided into two groups, namely, the intervention group and the control group, following the guidance of the stroke health manager. The control group patients received standard medical care during hospitalization, which consisted of advice on healthy lifestyle choices carried out by the bed nurse, but no structured education, WeChat group, or clinical consultation was included. The intervention group patients, in addition to the standard medical care, received health management and health education from the stroke health manager, and after hospital discharge, the patients were followed up over the telephone by the health manager to see if there was any recurrence or readmission.ResultsFrom 1 January 2018 to 31 December 2020, 382 patients with acute ischemic stroke were enrolled in this study. Through the univariate regression analysis, we found that SHM intervention was associated with a significantly lower risk of recurrence (HR = 0.459). We constructed a nomogram based on the significant variables from the regression analysis and also analyzed the association between the control group and the SHM intervention group among all subgroups using the Cox proportional hazards model to assess the effect of the stroke health management model. Most patients in this study had a total risk point between 170 and 270. The C-index value was 0.76, and the time-dependent AUC for predicting recurrence was &gt;0.7.ConclusionThe stroke health manager-guided management model based on patients' needs can better control the risk factors of stroke and significantly reduce the recurrence rate of mild to moderate ischemic stroke within 1 year.
Anti-glycine receptor antibody-positive progressive encephalomyelitis with rigidity and myoclonus initially presenting with one-sided stiff face: A case report
Authors: Irie Ken-Ichi , Tateishi Takahisa , Moritaka Taiga , Sakurada Naonori , Kikuchi Shinsuke , Taniwaki Takayuki 
Published: October 2022

BackgroundProgressive encephalomyelitis with rigidity and myoclonus (PERM) is a subtype of stiff-person syndrome, a rare cerebrospinal disease that causes brainstem symptoms, myoclonus, muscle rigidity, and hyperekplexia.Case presentationA 71-year-old man experienced left-sided stiff face, and was subsequently admitted to our hospital because of the appearance of left-dominant lower limb myoclonus. Muscle rigidity followed 3 days later. Magnetic resonance imaging revealed no abnormality. An electrophysiological examination showed a toughness of the antagonistic muscle following evocation of the Achilles tendon reflex, and a tonic phenomenon affecting the left facial muscles during the blink reflex. The patient's serum was positive for anti-glycine receptor (anti-GlyR) antibody, suggesting PERM. The patient was administered steroids, immunoglobulin therapy, and immunosuppressive drugs. He gradually improved after these therapies and became able to walk using a walker.ConclusionsWe conclude that this was a rare case of anti-GlyR antibody-positive PERM with unilateral brainstem symptoms, myoclonus, and muscle rigidity.
Causal relationship among obesity and body fat distribution and epilepsy subtypes
Authors: Zhou Kaiping , Yang Huan , Chen Ruomeng , Wang Weiping , Qu Zhenzhen 
Published: October 2022

ObjectiveThe observational studies indicate an association between obesity and epilepsy, but it is unclear whether such an association responds to causality. The objective of this study was to determine the causal relationship between obesity and fat distribution and epilepsy subtypes based on waist circumference, hip circumference (HP), waist-hip ratio (WHR), and body mass index (BMI).MethodsA two-sample Mendelian randomization study was conducted separately for the four indicators of obesity and epilepsy and its seven subtypes, with reverse Mendelian randomization and multivariate Mendelian randomization for significant outcomes.ResultsA two-sample Mendelian randomized analysis informed us that waist circumference was a risk factor for juvenile myoclonic epilepsy (beta = 0.0299, P = 4.60 × 10−3). The increase in hip circumference increased the risk of juvenile myoclonic epilepsy and epilepsy, with effect values of 0.0283 (P = 2.01 × 10−3) and 0.0928 (P = 1.40 × 10−2), respectively. Furthermore, children with a higher BMI exhibit a higher risk of epilepsy (beta = 0.0148 P = 1.05 × 10−3). The reverse Mendelian randomization study revealed that childhood absence epilepsy increased its BMI (beta = 0.8980, P = 7.52 × 10−7), and juvenile myoclonic epilepsy increased its waist circumference (beta = 0.7322, P = 3.26 × 10−2). Multivariate Mendelian randomization revealed that an increase in hip circumference and waist-hip ratio increased the risk of juvenile myoclonic epilepsy, with an effect value of 0.1051 (P = 9.75 × 10−4) and 0.1430 (P = 3.99 × 10−3), respectively, while an increase in BMI and waist circumference instead decreased their risk, with effect values of −0.0951 (P = 3.14 × 10−2) and−0.0541 (P = 1.71 × 10−2). In contrast, multivariate Mendelian randomization for childhood absence epilepsy and epilepsy did not identify any independent risk factors.SignificanceOur findings provide novel evidence in favor of obesity as a risk factor for epilepsy and waist circumference as a risk factor for juvenile myoclonic epilepsy. Increased hip circumference confers an elevated risk of juvenile myoclonic epilepsy and epilepsy (all documented cases), and a high BMI increases the risk of childhood absence epilepsy. With this, new insights are provided into the energy metabolism of epilepsy, which supports further nutritional interventions and the search for new therapeutic targets.