bluuebunny/crossref_metadata_2025_split huggingface dataset:
Crystallization‐Driven Controlled Two‐Dimensional (2D) Assemblies from Chromophore‐Appended Poly(L‐lactide)s: Highly Efficient Energy Transfer on a 2D Surface
Authors: Rajak Aritra , Das Anindita 
Published: February 2022

AbstractA rational approach towards precision two‐dimensional (2D) assemblies by crystallization‐driven self‐assembly (CDSA) of poly(L‐lactides) (PLLAs), end‐capped with dipolar dyes like merocyanine (MC) or naphthalene monoimide (NMI) and hydrophobic pyrene (PY) or benzene (Bn) is described. PLLA chains crystallize into diamond‐shaped platelets in isopropanol, which forces the terminal dyes to assemble into a 2D array on the platelet surface by either dipolar interactions or π‐stacking and exhibit tunable emission. Dipolar dyes play a critical role in imparting colloidal stability and structural uniformity to the 2D crystals, which is partly compromised for hydrophobic ones. Co‐crystallization between NMI‐ and PY‐labeled PLLAs yields similar diamond‐shaped co‐platelets with highly efficient (≈80 %) Förster Resonance Energy Transfer on the 2D surface. Further, the “living” CDSA method confers enlarged, segmented block co‐platelets using one of the homopolymers as “seed” and the other as “unimer”.
Local Symmetry Breaking Suppresses Thermal Conductivity in Crystalline Solids
Authors: Dutta Moinak , Prasad Matukumilli V. D. , Pandey Juhi , Soni Ajay , Waghmare Umesh V. , Biswas Kanishka 
Published: February 2022

AbstractUnderstanding the correlations of both the local and global structures with lattice dynamics is critical for achieving low lattice thermal conductivity (κlat) in crystalline materials. Herein, we demonstrate local cationic off‐centring within the global rock‐salt structure of AgSbSe2 by using synchrotron X‐ray pair distribution function analysis and unravel the origin of its ultralow κlat≈0.4 W mK−1 at 300 K. The cations are locally off‐centered along the crystallographic
direction by about ≈0.2 Å, which averages out as the rock‐salt structure on the global scale. Phonon dispersion obtained by density functional theory (DFT) shows weak instabilities that cause local off‐centering distortions within an anharmonic double‐well potential. The local structural distortion arises from the stereochemically active 5s2 lone pairs of Sb. Our findings open an avenue for understanding how the local structure influences the phonon transport and facilitates the design of next‐generation crystalline materials with tailored thermal properties.
Intra‐season variations in distribution and abundance of humpback whales in the West Antarctic Peninsula using cruise vessels as opportunistic platforms
Authors: Johannessen John Elling Deehr , Biuw Martin , Lindstrøm Ulf , Ollus Victoria Marja Sofia , Martín López Lucía Martina , Gkikopoulou Kalliopi C. , Oosthuizen Wessel Chris , Lowther Andrew 
Published: February 2022

AbstractFine‐scale knowledge of spatiotemporal dynamics in cetacean distribution and abundance throughout the Western Antarctic Peninsula (WAP) is sparse yet essential for effective ecosystem‐based management (EBM). Cruise vessels were used as platforms of opportunity to collect data on the distribution and abundance of humpback whales (Megaptera novaeangliae) during the austral summer of 2019/2020 in a region that is also important for the Antarctic krill (Euphausia superba) fishery, to assess potential spatiotemporal interactions for future use in EBM. Data were analyzed using traditional design‐based line transect methodology and spatial density surface hurdle models fitted using a set of physical environmental covariates to estimate the abundance and distribution of whales in the area, and to describe their temporal dynamics. Our results indicate a rapid increase in humpback whale abundance in the Bransfield and Gerlache Straits through December, reaching a stable abundance by mid‐January. The distribution of humpback whales appeared to change from a patchier distribution in the northern Gerlache Strait to a significantly concentrated presence in the central Gerlache and southern Bransfield Straits, followed by a subsequent dispersion throughout the area. Abundance estimates agreed well with previous literature, increasing from approximately 7000 individuals in 2000 to a peak of 19,107 in 2020. Based on these estimates, we project a total krill consumption of between 1.4 and 3.7 million tons based on traditional and contemporary literature on per capita krill consumption of whales, respectively. When taken in the context of krill fishery catch data in the study area, we conclude that there is minimal spatiotemporal overlap between humpback whales and fishery activity during our study period of November–January. However, there is potential for significant interaction between the two later in the feeding season, but cetacean survey efforts need to be extended into late season in order to fully characterize this potential overlap.
The relationship of benign prostatic hyperplasia's symptoms severity with the risk of developing atrial fibrillation
Authors: Koçak Ajar , Şenol Cem , Coşgun Ayhan , Eyyupkoca Ferhat , Yıldırım Onur 
Published: February 2022

AbstractBackgroundAttention is drawn to the increased incidence of atrial fibrillation (AF) in benign prostatic hyperplasia (BPH) patients recently. Early predicting of AF in these patients can help in decreasing its clinical consequences. The aim of our study is to determine the association between BPH symptoms and AF predictors atrial electromechanical delay (AEMD) and the P‐wave dispersion (PWD).Methods218 healthy individuals recently diagnosed with BPH were assigned into three groups according to symptoms severity using the International prostate symptom score (IPSS) questionnaire. The first group with mild symptoms (IPSS score between 0 and 7, n = 78), the second group with moderate symptoms (IPSS score between 8 and 19, n = 86), and the third group with severe symptoms (IPSS score between 20 and 35, n = 54). PWD and AEMD calculations were performed for all participants.ResultsThere were statistically significant differences between the three groups in terms of AEMD and PWD (p < .01 and p < .01, respectively). In all three study groups, a significant positive correlation was observed between IPSS questionnaire scores and both AEMD and PWD (for AEMD r = .29, p = .013 and for PWD r = .27, p = .017). On the other hand, there were significant differences between the three groups in terms of the inflammatory markers C‐reactive protein (CRP) and fibrinogen (p < .01 and p < .01, respectively) and in terms of serum testosterone levels (p < .01).ConclusionsWe concluded that periodic evaluation of patients with BPH in terms of symptoms severity can be helpful not only from urological aspect, but also in the early prediction of possible serious cardiovascular morbidity and mortality.
Implicit bias and negative stereotyping in global software development and why it is time to move on!
Authors: Matthiesen Stina , Bjørn Pernille , Trillingsgaard Claus 
Published: February 2022

AbstractPrior research documents how the use of national cultural differences when used as an argument for failed collaboration is problematic and makes information technology (IT) companies blind to the challenges in global software development (GSD). Nevertheless, we still witness how issues in GSD work are kept explained, applied, and predicted through generic descriptions of national cultural behavior. Based on two ethnographic studies conducted within two large Danish IT companies, we extend prior work on implicit bias. The paper presents empirical examples on the widespread practice of using racist and stereotypical rhetoric in GSD, which initially motivated us to look for alternative strategies for analyzing the actual and locally situated collaboration‐related problems within organizations involved in GSD. Our contributions are threefold: (1) We show how the widespread practice of using negative stereotypical rhetoric is weaved into the fabric of GSD engagements; (2) we present the empirical results of attending to implicit bias as an approach to explore and combat pervasive practices that deploy static cultural narratives and stereotypes in GSD; and (3) we propose three areas in GSD that software organizations should investigate to identify and address the implicit biases that potentially challenge or shatter their distributed collaborative work.
Ankle-Worn Sensor Sleeve to increase walking motivation
Authors: Sugimoto Minatsu , Iwata Hiroo , Igarashi Hiroya 
Published: February 2022

AbstractIn this study, we propose the Ankle-Worn Sensor Sleeve to help people maintain their health. Furthermore, our approach uses this sensor sleeve to improve walking motivation by making the walking motion more sensible. In this research, we pursue the design of a wearable device that users can wear as a “shoe accessory,” with the aim of promoting people’s walking motivation. This device is ankle-worn and generates electricity using the physical flexion and extension of the ankle, detects and acquires the amount of electricity generated, and uses the resulting power to produce sound and light feedback while walking. The Sleeve is designed to support health problems, such as locomotive syndrome and dementia, which are caused by physical inactivity. This article presents the results of a questionnaire survey conducted on 172 people who experienced or observed the device during exhibitions. The results reveal that this device increased people’s interest and motivation to walk, including those who did not like to walk.
Incidence of Complications for Different Approaches in Gynecomastia Correction: A Systematic Review of the Literature
Authors: Innocenti Alessandro , Melita Dario , Dreassi Emanuela 
Published: February 2022

Abstract
Background
Gynecomastia is nowadays a very common disease, affecting a large cohort of patients with different ages. The aim of this literature review is to assess the incidence of complications with all proposed techniques and for combined procedures versus single approach procedures in gynecomastia correction.

Materials and Methods
A systematic review of the literature was performed to identify all reported techniques for gynecomastia correction covering a period from January 1, 1987 to November 1, 2020. For all selected papers, demographic data, proposed technique, and complications’ incidence have been recorded.

Results
A total number of 3970 results was obtained from database analysis. A final total number of 94 articles was obtained for 7294 patients analyzed. Patients have been divided into three groups: aspiration techniques, consisting in 874 patients (11,98%), surgical excision techniques, consisting in 2764 patients (37,90%), and combined techniques, consisting in 3656 patients (50,12%). Complications have been recorded for all groups, for a total number of 1407, of which 130 among “Aspiration techniques” group (14,87%), 847 among “Surgical excision techniques” group (30,64%), and 430 in “Combined techniques” group (11,76%).

Conclusions
Several techniques have been proposed in the literature to address gynecomastia, with the potential to greatly improve self-confidence and overall appearance of affected patients. The combined use of surgical excision and aspiration techniques seems to reduce the rate of complications compared to surgical excision alone, but the lack of unique classification and the presence of several surgical techniques still represents a bias in the literature review.

Level of Evidence III
This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266.
Brain region-specific susceptibility of Lewy body pathology in synucleinopathies is governed by α-synuclein conformations
Authors: de Boni Laura , Watson Aurelia Hays , Zaccagnini Ludovica , Wallis Amber , Zhelcheska Kristina , Kim Nora , Sanderson John , Jiang Haiyang , Martin Elodie , Cantlon Adam , Rovere Matteo , Liu Lei , Sylvester Marc , Lashley Tammaryn , Dettmer Ulf , Jaunmuktane Zane , Bartels Tim 
Published: February 2022

AbstractThe protein α-synuclein, a key player in Parkinson’s disease (PD) and other synucleinopathies, exists in different physiological conformations: cytosolic unfolded aggregation-prone monomers and helical aggregation-resistant multimers. It has been shown that familial PD-associated missense mutations within the α-synuclein gene destabilize the conformer equilibrium of physiologic α-synuclein in favor of unfolded monomers. Here, we characterized the relative levels of unfolded and helical forms of cytosolic α-synuclein in post-mortem human brain tissue and showed that the equilibrium of α-synuclein conformations is destabilized in sporadic PD and DLB patients. This disturbed equilibrium is decreased in a brain region-specific manner in patient samples pointing toward a possible “prion-like” propagation of the underlying pathology and forms distinct disease-specific patterns in the two different synucleinopathies. We are also able to show that a destabilization of multimers mechanistically leads to increased levels of insoluble, pathological α-synuclein, while pharmacological stabilization of multimers leads to a “prion-like” aggregation resistance. Together, our findings suggest that these disease-specific patterns of α-synuclein multimer destabilization in sporadic PD and DLB are caused by both regional neuronal vulnerability and “prion-like” aggregation transmission enabled by the destabilization of local endogenous α-synuclein protein.
A multi-method assessment of 3D printed micromorphological osteological features
Authors: Carew Rachael M. , Iacoviello Francesco , Rando Carolyn , Moss Robert M. , Speller Robert , French James , Morgan Ruth M. 
Published: February 2022

AbstractThe evaluation of 3D printed osteological materials has highlighted the difficulties associated with accurately representing fine surface details on printed bones. Moreover, there is an increasing need for reconstructions to be demonstrably accurate and reliable for use in the criminal justice system. The aim of this study was to assess the surface quality of 3D prints (n = 9) that presented with micromorphological alterations from trauma, taphonomy and pathology processes. The archaeological bones were imaged using micro-CT scanning and 3D printed with selective laser sintering (SLS) printing. A multi-method experimental approach subsequently identified: (1) the 3D printed bones to be metrically accurate to within 1.0 mm; (2) good representation of micromorphological surface features overall, albeit with some loss of intricate details, depths, and fine textures that can be important for visual processing; (3) five of the nine 3D printed bones were quantitatively scored as accurate using the visual comparison method; and, (4) low mesh comparison distances (± 0.2 mm) between the original models and the digitised 3D print models. The findings offer empirical data that can be used to underpin 3D printed reconstructions of exhibits for use in courts of law. In addition, an adaptable pathway was presented that can be used to assess 3D print accuracy in future reconstructions.
Dealing with the stochastic prosumager problem with controllable loads
Authors: Violi Antonio , Beraldi Patrizia , Carrozzino Gianluca 
Published: February 2022

AbstractThis paper focuses on the home energy management for a residential prosumager with flexible loads. In particular, three different types of controllable appliances (shiftable, interruptible, thermostatically controllable) have been considered, each one with a specific representation of energy consumption profile and a potential discomfort rate for the user. The inherent uncertainty affecting the main model parameters (i.e., non- controllable loads, solar production, external temperature) is explicitly accounted for by adopting the two-stage stochastic programming modeling paradigm. The model solution provides the prosumager with the optimal scheduling of the controllable loads and the operation of the storage system that guarantee the minimum expected energy procurement cost, taking into account the overall discomfort. A preliminary computational experience has shown the effectiveness of the proposed approach in terms of cost savings and the advantage related to the use of a stochastic programming approach over a deterministic formulation.
Hemodynamic response and clinical outcome following intravenous milrinone plus norepinephrine–based hyperdynamic hypertensive therapy in patients suffering secondary cerebral ischemia after aneurysmal subarachnoid hemorrhage
Authors: Steiger Hans-Jakob , Ensner Rolf , Andereggen Lukas , Remonda Luca , Berberat Jatta , Marbacher Serge 
Published: February 2022

Abstract
Purpose
Intravenous and intra-arterial milrinone as a rescue measure for delayed cerebral ischemia (DCI) after subarachnoid hemorrhage (SAH) has been adopted by several groups, but so far, evidence for the clinical benefit is unclear and effect on brain perfusion is unknown. The aim of the actual analysis was to define cerebral hemodynamic effects and outcome of intravenous milrinone plus norepinephrine supplemented by intra-arterial nimodipine as a rescue strategy for DCI following aneurysmal SAH.

Methods
Of 176 patients with aneurysmal SAH treated at our neurosurgical department between April 2016 and March 2021, 98 suffered from DCI and were submitted to rescue therapy. For the current analysis, characteristics of these patients and clinical response to rescue therapy were correlated with hemodynamic parameters, as assessed by CT angiography (CTA) and perfusion CT. Time to peak (TTP) delay in the ischemic focus and the volume with a TTP delay of more than 4 s (T4 volume) were used as hemodynamic parameters.

Results
The median delay to neurological deterioration following SAH was 5 days. Perfusion CT at that time showed median T4 volumes of 40 cc and mean focal TTP delays of 2.5 ± 2.1 s in these patients. Following rescue therapy, median T4 volume decreased to 10 cc and mean focal TTP delay to 1.7 ± 1.9 s. Seventeen patients (17% of patients with DCI) underwent additional intra-arterial spasmolysis using nimodipine. Visible resolution of macroscopic vasospasm on CTA was observed in 43% patients with DCI and verified vasospasm on CTA, including those managed with additional intra-arterial spasmolysis. Initial WFNS grade, occurrence of secondary infarction, ischemic volumes and TTP delays at the time of decline, the time to clinical decline, and the necessity for additional intra-arterial spasmolysis were identified as the most important features determining neurological outcome at 6 months.

Conclusion
The current analysis shows that cerebral perfusion in the setting of secondary cerebral ischemia following SAH is measurably improved by milrinone and norepinephrine–based hyperdynamic therapy. A long-term clinical benefit by the addition of milrinone appears likely. Separation of the direct effect of milrinone from the effect of induced hypertension is not possible based on the present dataset.
Diagnostic performance and clinical feasibility of a novel one-step RT-qPCR assay for simultaneous detection of multiple severe acute respiratory syndrome coronaviruses
Authors: Le Tran Bac , Kim Hye Kwon , Ahn Min-Ju , Zanin Mark , Lo Van Thi , Ling Shiman , Jiang Zhanpeng , Kang Jung-Ah , Bae Pan Kee , Kim Yeon-Sook , Kim Seungtaek , Wong Sook-San , Jeong Dae Gwin , Yoon Sun-Woo 
Published: February 2022

AbstractCoronavirus disease 2019 (COVID-19) is an acute respiratory infection caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Other coronaviruses (CoVs) can also infect humans, although the majority cause only mild respiratory symptoms. Because early diagnosis of SARS-CoV-2 is critical for preventing further transmission events and improving clinical outcomes, it is important to be able to distinguish SARS-CoV-2 from other SARS-related CoVs in respiratory samples. Therefore, we developed and evaluated a novel reverse transcription quantitative polymerase chain reaction (RT-qPCR) assay targeting the genes encoding the spike (S) and membrane (M) proteins to enable the rapid identification of SARS-CoV-2, including several new circulating variants and other emerging SARS-like CoVs. By analysis of in vitro-transcribed mRNA, we established multiplex RT-qPCR assays capable of detecting 5 × 10° copies/reaction. Using RNA extracted from cell culture supernatants, our multiple simultaneous SARS-CoV-2 assays had a limit of detection of 1 × 10° TCID50/mL and showed no cross-reaction with human CoVs or other respiratory viruses. We also validated our method using human clinical samples from patients with COVID-19 and healthy individuals, including nasal swab and sputum samples. This novel one-step multiplex RT-qPCR assay can be used to improve the laboratory diagnosis of human-pathogenic CoVs, including SARS-CoV-2, and may be useful for the identification of other SARS-like CoVs of zoonotic origin.
Appearance-based loop closure detection combining lines and learned points for low-textured environments
Authors: Company-Corcoles Joan P. , Garcia-Fidalgo Emilio , Ortiz Alberto 
Published: February 2022

AbstractHand-crafted point descriptors have been traditionally used for visual loop closure detection. However, in low-textured environments, it is usually difficult to find enough point features and, hence, the performance of such algorithms degrade. Under this context, this paper proposes a loop closure detection method that combines lines and learned points to work, particularly, in scenarios where hand-crafted points fail. To index previous images, we adopt separate incremental binary Bag-of-Words (BoW) schemes for points and lines. Moreover, we adopt a binarization procedure for features’ descriptors to benefit from the advantages of learned features into a binary BoW model. Furthermore, image candidates from each BoW instance are merged using a novel query-adaptive late fusion approach. Finally, a spatial verification stage, which integrates appearance and geometry perspectives, allows us to enhance the global performance of the method. Our approach is validated using several public datasets, outperforming other state-of-the-art solutions in most cases, especially in low-textured scenarios.