bluuebunny/crossref_metadata_2025_split huggingface dataset:
Denationalisation and discrimination in postcolonial India
Authors: Choudhury Sumedha 
Published: July 2022

With the recent National Register of Citizens updating process in Assam (a northeastern state in India) and the Citizenship Amendment Act (CAA 2019), there have been significant changes to India’s citizenship laws and policies. This may create one of the world’s largest stateless populations in modern times. These changes manifest the government’s othering process of creating binaries of belonging and non-belongingness between the majority Hindus and minorities (especially followers of the Islamic faith). In this article, taking these recent changes to citizenship as a case study, I discuss how India’s colonial past, the experience of partition, and the henceforth nation-building contributed to perceiving the ‘citizen’ primarily along Hindu majoritarian lines. I argue that the nation-building process in India was based on retaining and simultaneously re-establishing the ‘others’, thereby reinforcing colonial legacies in the structure and functioning of the postcolonial state. Consequently, this article deals with two questions, first, how the adoption of discriminatory citizenship laws and the risk of statelessness in India is rooted in its complex history, the impact of British colonial expansion and the postcolonial realities and second, what role ‘law’ has played in the process.
Bilingual processing of case-marking and locative verbs in Korean: Use of L2-unique information
Authors: Park Sun Hee , Kim Hyunwoo 
Published: July 2022

Aims and objectives/purpose/research questions: Previous studies show conflicting findings regarding bilingual processing of target information not instantiated in learners’ first language. The current study addresses this issue by investigating whether Chinese speakers can integrate case-marking information, which is unique to Korean, with locative verb information in their processing of the Korean locative constructions. Design/methodology/approach: We conducted an acceptability judgment task to assess Chinese–Korean bilinguals’ explicit knowledge of case-marking constraints on Korean locative constructions, and a self-paced reading task to probe their application of the knowledge to real-time sentence processing. Data and analysis: Twenty-four advanced Chinese–Korean bilinguals’ acceptability judgments and reading times were compared with those of 24 Korean monolingual speakers, using mixed-effects regression modeling. Findings/conclusions: Results from the offline acceptability judgment task revealed the bilinguals’ native-like judgment patterns. Both Korean monolingual and Chinese–Korean bilinguals rejected sentences with wrong case-marking sequences paired with locative verbs. In the self-paced reading task, both monolingual and bilingual speakers showed increased reading times when a mismatch arose between case-marking and locative verb information, indicating their sensitivity to locative agreement violations. Originality: While previous studies have investigated bilinguals’ integration of multiple sources of information, this study adds a new perspective to this issue by testing whether bilinguals can use L2-unique information (i.e., case marking) to integrate it with other types of information (i.e., locative verbs) for sentence processing. Significance/implications: Our findings are consistent with the competition model which predicts that L2-unique information presents little processing difficulty for bilinguals. At the same time, the current results lend credence to the idea that increased proficiency allows bilinguals to integrate multiple information sources during processing.
Late Endograft Migration After Thoracic Endovascular Aortic Repair: A Systematic Review and Meta-analysis
Authors: Skrypnik Denis , Kalmykov Egan , Bischoff Moritz S. , Meisenbacher Katrin , Klotz Rosa , Hagedorn Matthias , Kalkum Eva , Probst Pascal , Dammrau Rolf , Böckler Dittmar 
Published: July 2022

Purpose: The objective of this systematic review was to report the cumulative incidence of endograft migration (EM), as well as the morbidity, reintervention rates, and mortality related to EM. This study aimed to provide evidence-based data on patient-relevant sequelae of EM after thoracic endovascular aortic repair (TEVAR) performed using contemporary aortic endografts. Materials and Methods: A systematic electronic search of literature in MEDLINE (via PubMed), Web of Science, and Cochrane Central Register of Controlled Trials was performed. The pooled synthesis of outcomes was performed using the inverse variance method. Results: Seven prospective non-randomized and 4 retrospective studies, including a total of 1783 patients presenting 70 EMs, were considered for the quantitative analysis. The pooled rate of EM was 4% (95% CI, 2%–7%; range, 0.2%–11%; I2=82%); pooled morbidity rate was 31% (95% CI, 12%–59%; range, 0%–100%; I2=64%) and pooled reintervention rate was 32% (95% CI, 15%–56%; range, 0%–100%; I2=55%). The pooled mortality rate due to EM was 5% (95% CI, 1%–21%; range, 0%–40%; I2=24%). Conclusion: For the first time, this meta-analysis provides pooled reference estimates of EM after TEVAR. Thus, the results hold the potential to further characterize EM after TEVAR. The clinical relevance of EM is underlined by its association with high rates of endoleak-related morbidity, reintervention, and mortality. Close standardized surveillance after TEVAR for early detection of EM and prophylaxis of its sequelae is essential.
Cabozantinib for the treatment of solid tumors: a systematic review
Authors: Maroto Pablo , Porta Camillo , Capdevila Jaume , Apolo Andrea B. , Viteri Santiago , Rodriguez-Antona Cristina , Martin Lidia , Castellano Daniel 
Published: July 2022

Background: Cabozantinib is approved, in various settings, for the treatment of renal cell carcinoma, medullary thyroid cancer, and hepatocellular carcinoma, and it has been investigated for the treatment of other cancers. With the available evidence and the real-world performance of cabozantinib compared with clinical trial data, we performed a systematic review of cabozantinib monotherapy as treatment for solid tumors in adults. Methods: This study was designed in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses and registered with PROSPERO (CRD42020144680). We searched for clinical and observational studies of cabozantinib monotherapy for solid tumors using Embase, MEDLINE, and Cochrane databases (October 2020), and screened relevant congress abstracts. Eligible studies reported clinical or safety outcomes, or biomarker data. Small studies ( n < 25) and studies of cabozantinib combination therapies were excluded. Quality was assessed using National Institute for Health and Care Excellence methodology, and study characteristics were described qualitatively. Results: Of 2888 citations, 114 were included (52 randomized studies, 29 observational studies, 32 nonrandomized phase I or II studies or pilot trials, and 1 analysis of data from a randomized study and a nonrandomized study). Beyond approved indications, other tumors studied were castration-resistant prostate cancer, urothelial carcinoma, Ewing sarcoma, osteosarcoma, uveal melanoma, non-small-cell lung cancer, Merkel cell carcinoma, glioblastoma, pheochromocytomas and paragangliomas, cholangiocarcinoma, gastrointestinal stromal tumor, colorectal cancer, salivary gland cancer, carcinoid and pancreatic neuroendocrine tumors, and breast, endometrial and ovarian cancers. The most common adverse events were hypertension, diarrhea, and fatigue. Conclusion: The identified evidence demonstrates the positive efficacy/effectiveness of cabozantinib monotherapy in various solid tumor types, with safety findings being consistent with those observed with other VEGFR-targeting tyrosine kinase inhibitors. When available, real-world findings were consistent with the data reported from clinical trials. A limitation of this review is the high proportion of abstracts; however, this allowed us to capture the most up-to-date findings.
A 40-Year-Old Woman With COVID-19 and Bilateral Vision Loss
Authors: Jain Varun , Senetar Alexander J. , Maciel Carolina B , Remley William , Islam Shehla , Fredenburg Kristianna M. , Babi Marc A , Robinson Christopher P. 
Published: July 2022

Mucormycosis is a fast-spreading angioinvasive fungal infection with a very high mortality rate. It is associated with immunodeficiency, diabetes mellitus, iron overload, stem cell transplantation and the use of steroids. As cultures and histopathological biopsy may have low yield in invasive fungal infections, new generation sequencing of cfDNA (cell free deoxyribonucleic acid) has become a cornerstone for diagnosis. Over the past 18 months, increasing reports of COVID-19 associated Mucormycosis have emerged, most specifically in India and other nearby developing countries. Awareness and knowledge of this newly discovered association is of high importance and clinical relevance as the global COVID-19 pandemic continues. Herein, we present a case of a patient who was treated with steroids for COVID-19 in the outpatient setting and presented with unilateral periorbital pain and blurry vision. She progressively developed bilateral vision loss, fixed bilateral mydriasis, ophthalmoplegia and coma. Imaging findings included leptomeningeal, vascular, and subcortical enhancement accompanied with multifocal infarction. Subsequent biopsy of the paranasal sinuses revealed broad type fungal elements and cfDNA sequencing identified the pathogen as Rhizopus species. She was treated with intravenous amphotericin B, but succumbed to the infection.
Complications of Pediatric Mandibular Distraction Osteogenesis Hardware: A 10-Year Retrospective Analysis of the Food and Drug Administration Manufacturer and User Facility Device Experience Database
Authors: Jinka Sanjay K.A. , Coombs Demetrius M. , Murthy Ananth S. 
Published: July 2022

Background: The United States Food and Drug Administration’s (FDA) Manufacturer and User Facility Device Experience (MAUDE) database provides access to device related adverse event reports. This database mandates national reporting of complications that lead to “death and serious injury” by manufacturers, importers, and device user facilities. This study used MAUDE to conduct post-market surveillance of pediatric mandibular distraction osteogenesis (MDO) hardware. Methods: A MAUDE database search with terms related to mandibular distraction was performed for report dates between October 1st, 2011, and October 1st, 2021. Duplicate reports, reports from literature reviews, and vague reports were removed. Manufacturers were contacted to establish which devices were pediatric-use-only. Adult-use and mixed-use devices were excluded. Each remaining report was manually reviewed/categorized to compile summative data. Results: Seventy pediatric-use-only device reports were identified. The damaged/non-functioning part of the device included the distractor itself (57.14% of reports), footplate(s) (37.14%), or screw(s) (5.71%). Intraoperative and postoperative complications made up 15.71% and 84.29% of reports, respectively. Twenty percent of complications occurred during the activation phase and 1.43% occurred during device removal. The most common report was failure of the device to advance (37.14% of total complications). Some form of operative treatment or explantation was performed for 51.43% and 34.29% of complications, respectively. External distractors and related hardware made up 8.6% of reports and the most common complication in this group was the screw backing out at 33.3% of all reports. Conclusions: The MAUDE database is a useful tool in evaluation of MDO device-related incidents. Most complications occur in the postoperative period, during the distraction phase, and often require device removal. The most common complication in external distractors was screws backing out. Mindful activation of the distractor, careful device/screw handling, technical improvement of the devices, and thorough preoperative planning may minimize these untoward events.
Crystal chemistry and Raman spectroscopy study of bennesherite, Ba2Fe2+Si2O7, and rare accessory Ba minerals from Caspar quarry, Bellerberg volcano, Germany
Authors: Juroszek Rafał , Ternes Bernd 
Published: July 2022

AbstractBarium melilite – bennesherite, Ba2Fe2+Si2O7, known only from pyrometamorphic rocks of the Hatrurim Complex in Israel, has been recognised in a carbonate–silicate xenolith from the Bellerberg volcano area in Germany. The empirical formula of the German specimen is as follows: (Ba1.32Ca0.43Sr0.23Na0.05K0.02)Σ2.05(Fe2+0.79Ti0.06Mg0.05Al0.04Mn0.03Zn0.01)Σ0.98Si1.97O7. The Raman spectrum of bennesherite exhibits the presence of the main vibrations related to Fe2+O4 tetrahedra and disilicate Si2O7 groups at the T1 and T2 sites, at 589 cm–1 and in the range 618–673 cm–1, respectively. Detailed spectroscopic analyses performed for bennesherite in two different and random orientations confirm the reduction of bands intensity and the number of some components in several spectral ranges. Moreover, the presence of a heavy Ba atom indicates a decrease in band frequencies compared to melilites with Ca at the X position. A single-crystal X-ray diffraction experiment, despite attempts, could not be carried out due to the poor quality and small size of the bennesherite crystals however, a combination of composition and Raman data allowed for accurate phase identification. Detailed mineralogical investigations distinguished rare Ba minerals in association with bennesherite, such as walstromite, fresnoite and celsian, along with various ferrous melilites. Some of the detected phases are described from xenoliths of the Bellerberg volcano for the first time. The uniqueness of the Bellerberg volcano mineralisation is reflected in the interaction of alkaline magma with xenoliths of different compositions, which suggests that this locality still deserves attention as a source of new and unique minerals.
Impact of pulmonary embolism response teams on acute pulmonary embolism: a systematic review and meta-analysis
Authors: Fleitas Sosa Derlis , Lehr Andrew L. , Zhao Huaqing , Roth Stephanie , Lakhther Vlad , Bashir Riyaz , Cohen Gary , Panaro Joseph , Maldonado Thomas S. , Horowitz James , Amoroso Nancy E. , Criner Gerard J. , Brosnahan Shari B. , Rali Parth 
Published: July 2022

BackgroundThe impact of pulmonary embolism response teams (PERTs) on treatment choice and outcomes of patients with acute pulmonary embolism (PE) is still uncertain.ObjectiveTo determine the effect of PERTs in the management and outcomes of patients with PE.MethodsPubMed, Embase, Web of Science, CINAHL, WorldWideScience and MedRxiv were searched for original articles reporting PERT patient outcomes from 2009. Data were analysed using a random effects model.Results16 studies comprising 3827 PERT patients and 3967 controls met inclusion criteria. The PERT group had more patients with intermediate and high-risk PE (66.2%) compared to the control group (48.5%). Meta-analysis demonstrated an increased risk of catheter-directed interventions, systemic thrombolysis and surgical embolectomy (odds ratio (OR) 2.10, 95% confidence interval (CI) 1.74–2.53; p<0.01), similar bleeding complications (OR 1.10, 95% CI 0.88–1.37) and decreased utilisation of inferior vena cava (IVC) filters (OR 0.71, 95% CI 0.58–0.88; p<0.01) in the PERT group. Furthermore, there was a nonsignificant trend towards decreased mortality (OR 0.87, 95% CI 0.71–1.07; p=0.19) with PERTs.ConclusionsThe PERT group showed an increased use of advanced therapies and a decreased utilisation of IVC filters. This was not associated with increased bleeding. Despite comprising more severe PE patients, there was a trend towards lower mortality in the PERT group.
scDLC: a deep learning framework to classify large sample single-cell RNA-seq data
Authors: Zhou Yan , Peng Minjiao , Yang Bin , Tong Tiejun , Zhang Baoxue , Tang Niansheng 
Published: July 2022

Abstract
Background
Using single-cell RNA sequencing (scRNA-seq) data to diagnose disease is an effective technique in medical research. Several statistical methods have been developed for the classification of RNA sequencing (RNA-seq) data, including, for example, Poisson linear discriminant analysis (PLDA), negative binomial linear discriminant analysis (NBLDA), and zero-inflated Poisson logistic discriminant analysis (ZIPLDA). Nevertheless, few existing methods perform well for large sample scRNA-seq data, in particular when the distribution assumption is also violated.

Results
We propose a deep learning classifier (scDLC) for large sample scRNA-seq data, based on the long short-term memory recurrent neural networks (LSTMs). Our new scDLC does not require a prior knowledge on the data distribution, but instead, it takes into account the dependency of the most outstanding feature genes in the LSTMs model. LSTMs is a special recurrent neural network, which can learn long-term dependencies of a sequence.

Conclusions
Simulation studies show that our new scDLC performs consistently better than the existing methods in a wide range of settings with large sample sizes. Four real scRNA-seq datasets are also analyzed, and they coincide with the simulation results that our new scDLC always performs the best. The code named “scDLC” is publicly available at https://github.com/scDLC-code/code.
Spatial correction improves accuracy of catheter positioning during ablation of premature ventricular contractions: differences between ventricular outflow tracts and other localizations
Authors: Nies M. , Schleberger R. , Dinshaw L. , Klatt N. , Muenkler P. , Jungen C. , Rottner L. , Lemoine M. D. , Reißmann B. , Rillig A. , Metzner A. , Kirchhof P. , Meyer C. 
Published: July 2022

Abstract
Background
Hybrid activation mapping is a novel tool to correct for spatial displacement of the mapping catheter due to asymmetrical contraction of myocardium during premature ventricular contractions (PVC). The aim of this study is to describe and improve our understanding of spatial displacement during PVC mapping as well as options for correction using hybrid activation mapping.

Methods and results
We analyzed 5798 hybrid mapping points in 40 acquired hybrid maps of 22 consecutive patients (age 63 ± 16 years, 45% female) treated for premature ventricular contractions (PVCs). Median PVC-coupling interval was 552 ms (IQR 83 ms). Spatial displacement was determined by measuring the dislocation of the catheter tip during PVC compared to the preceding sinus beat. Mean spatial displacement was 3.8 ± 1.5 mm for all maps. The displacement was 1.3 ± 0.4 mm larger for PVCs with non-outflow-tract origin compared to PVCs originating from the ventricular outflow tracts (RVOT/LVOT; p = 0.045). Demographic parameters, PVC-coupling-interval and chamber of origin had no significant influence on the extent of spatial displacement.

Conclusion
Ectopic activation of the ventricular myocardium during PVCs results in spatial displacement of mapping points that is significantly larger for PVCs with non-outflow-tract origin. The correction for spatial displacement may improve accuracy of radiofrequency current (RFC)-application in catheter ablation of PVCs.
Barriers and facilitators for therapeutic drug monitoring of beta-lactams and ciprofloxacin in the ICU: a nationwide cross-sectional study
Authors: Ewoldt Tim M. J. , Abdulla Alan , van den Broek Puck , Hunfeld Nicole , Bahmany Soma , Muller Anouk E. , Gommers Diederik , Polinder Suzanne , Endeman Henrik , Spronk Inge , Koch Birgit C. P. 
Published: July 2022

Abstract
Background
Recent studies demonstrated that failure of achieving pharmacodynamic targets of commonly used antibiotics is common in critically ill patients. Therapeutic drug monitoring (TDM) can contribute to optimize the exposure of beta-lactams and ciprofloxacin. While evidence for TDM of these antibiotics is growing, translation into clinical implementation remains limited. Therefore, perceived barriers and facilitators are important for implementing TDM in this population. The primary aim of this study was to identify healthcare professionals’ barriers and facilitators for the implementation of TDM of beta-lactams and ciprofloxacin in Dutch intensive care units (ICU).

Methods
We conducted a nationwide cross-sectional online survey among healthcare professionals (HCPs) involved in antibiotic treatment of ICU patients. An adapted version of the Measurement Instrument for Determinants of Innovations was sent out. Items were considered barriers when ≥ 20% of participants responded with a negative answer. If ≥ 80% of the participants responded with a positive answer, the item was considered a facilitator.

Results
Sixty-four HCPs completed the survey, of which 14 were from academic hospitals, 25 from general hospitals, and 25 from teaching hospitals. Most participants were hospital pharmacists (59%) or medical specialists (23%). Eleven barriers and four facilitators for implementation of TDM of beta-lactams were identified; 17 barriers for TDM of ciprofloxacin and no facilitators. The most important barriers were a lack of conclusive evidence, organizational support, and low availability of assays. Additional barriers were a lack of consensus on which specific patients to apply TDM and which pharmacodynamic targets to use. Identified facilitators for beta-lactam TDM implementation are low complexity and high task perception, combined with the perception that TDM is important to prevent side effects and to adequately treat infections. Twenty-eight percent of participants reported that flucloxacillin could be analyzed in their hospital. Assay availability of other beta-lactams and ciprofloxacin was lower (3–17%).

Conclusion
Several barriers were identified that could obstruct the implementation of TDM of beta-lactams and ciprofloxacin in the ICU. In particular, education, clear guidelines, and organizational support should be considered when creating tailored implementation strategies. Finally, evidence of beneficial clinical outcomes on TDM of beta-lactams and ciprofloxacin can enhance further implementation.
Risk factors influencing cerebral venous infarction after meningioma resection
Authors: Cai Qing , Wang Shoujie , Zheng Min , Wang Xuejiao , Liu Rong , Liu Liqin , Qin Huaizhou , Feng Dayun 
Published: July 2022

Abstract
Background
Cerebral venous infarction (CVI) is a serious complication after meningioma resection. The risk factors of postoperative cerebral venous infarction after surgical resection of meningioma can be determined through large samples and this study can add evidence to the literature.

Methods
The clinical and imaging data of 1127 patients with intracranial meningiomas who underwent resection in our hospital were retrospectively collected and analyzed. CVI was evaluated by postoperative imaging and clinical manifestations. Univariate and multivariate analyses were performed to identify risk factors associated with CVI.

Results
Overall, 4.7% (53/1127) of patients experienced CVI after meningioma resection. Multivariate analysis revealed superficial meningioma, moderate to severe peritumoral edema, peritumoral critical vein and WHO grade II-III as independent predictors of a postoperative CVI. After timely intervention, the symptoms were clearly alleviated in one month, and the prognosis was good, but injury to key veins could cause irreversible neurological disorders.

Conclusions
Intraoperative protection of veins is the primary way to prevent CVI. The present study identified several significant and independent risk factors for postoperative venous infarction, thereby enabling the identification of high-risk patients who require special attention during clinical and surgical management.