bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analisis Kolom Beton Bertulang Baja Ringan
Authors: Nursyifa Zakiah , Walujodjati Eko 
Published: June 2022

Beton dengan tulangan profil baja ringan merupakan alternatif pengganti tulangan baja konvensional yang umumnya digunakan pada beton bertulang. Penggantian tulangan ini dimaksudkan untuk dapat mampu menerima perilaku bolak-baliknya struktur yang ditimbulkan dari beban gempa. Salah satu elemen penyusun pada struktur yang paling penting yaitu struktur kolom. Karena kolom merupakan elemen penghubung dari struktur atas ke struktur bawah sampai ke tanah. Mengingat baja ringan memiliki ketebalan yang cukup tipis, maka baja ringan ini rentan terhadap tekuk. Dengan menggunakan baja ringan tipe C, baja ringan ini disusun secara double profil dan diikat dengan tulangan geser pelat kopel dengan mengambil gedung rumah 1 lantai sebagai objek penelitian. Metode penelitian yang digunakan merupakan metode kuantitatif, sehingga penelitian ini banyak membahas mengenai angka-angka. Penelitian yang dilakukan yaitu dengan menganalisis struktur 3D dari beban-beban luar sebagai beban aksial yang akan menumpu pada kolom, kemampuan kolom beserta perencanaan tulangan gesernya, serta evaluasi-evaluasi terhadap material penyusun kolom struktur. Hasil dari penelitian bahwa kolom berukuran 23 x 23 cm dengan menggunakan beton bertulang baja ringan tipe C 150.50.12 dapat mampu menahan beban sebesar 32529,654 Kg dengan fc’ 7,4 MPa dan 87554,4 Kg dengan fc’ 31,2 MPa sehingga beton bertulang ini dapat dikatakan layak dalam mengganti tulangan baja konvensional untuk kondisi desain bangunan tersebut. Beton bertulang baja ringan ini juga dipasang dengan 10 pelat kopel berdimensi 1,1 x 70 mm dan 12 sambungan screw per pelat dalam menahan gaya geser yang terjadi pada kolom. Selain itu, untuk evalusi terhadap komponen material penyusun beton bertulang baja ringan tersebut dapat dikatakan aman untuk digunakan. Namun perlu untuk hati-hati terhadap keruntuhan tekan yang akan terjadi jika struktur mengalami kegagalan material.
Pengaruh Simpang Bersinyal Terhadap Kinerja Lalu Lintas
Authors: Milenia Eva Detria , Farida Ida 
Published: June 2022

Simpang tiga Jalan Otista-Jalan Raya Samarang Garut merupakan jalan dengan lingkungan komersial di Kota Garut, sehingga volume kendaraan yang melewati persimpangan tersebut cukup padat terutama pada lengan barat. Pada persimpangan tersebut telah terpasang APILL maka dari itu penelitian ini bertujuan untuk mengetahui pengaruh simpang bersinyal di Jl. Otista – Jl. Raya Samarang Garut. Data dari penelitian ini diperoleh dari observasi lapangan, pengolahan data menggunakan PKJI 2014 dan Software Simulasi Lalu Lintas Vissim. Hasil penelitian didapat Dj tertinggi senilai 0,858 hari Senin siang pada lengan Barat dan terendah hari Minggu pagi dengan nilai 0,701 di lengan Selatan. Dengan nilai tundaan rata-rata tertinggi senilai 29,55 det/skr hari Senin di lengan Selatan, dan nilai tundaan rata-rata terendah hari Minggu di lengan Barat senilai 19,37 det/skr, dengan nilai ITP berdasarkan tundaan rata-rata simpang adalah C, dimana arus lalu lintas hampir tidak stabil. Untuk meningkatkan kinerja lalu lintas, diberikan alternatif yakni memodifikasi APILL yang mampu menurunkan nilai panjang antrian sebesar 19% dan tundaan 59% dari sebelumnya.
Avaliação fitoquímica de folhas, talos e inflorescência de Piper tuberculatum e Piper hispidum
Authors: Freire Tamiris Chaves , Sangi Simone Carvalho , Bastos Jessica Silva Félix , Fonseca Aline Souza da , Silva Renata Reis da , Vieira Junior José Roberto , Fernandes Cléberson de Freitas 
Published: June 2022

O gênero Piper é amplamente utilizado para as mais diferentes finalidades, logo, o aprofundamento fitoquímico se faz necessário. Este trabalho teve o objetivo de identificar os metabólitos de folhas, talos e inflorescência de Piper tuberculatum e Piper hispidum. O material vegetal foi obtido no campo experimental e avaliado no laboratório de fitopatologia da Embrapa Rondônia. A presença de alcaloides foi confirmada em todas as amostras quando utilizado o reagente de Dragendorff, presença de saponinas em folhas e talos de P. tuberculatum e talos de P. hispidum, flavonoides em todas as partes de P. tuberculatum e talos e inflorescência de P. hispidum, taninos, cumarinas foi encontrada em todas as amostras, compostos fenólicos foram observados em folhas de P. tuberculatum e folhas e inflorescência de P. hispidum, os triterpenos foram encontrados em talos e inflorescência de P. tuberculatum e P. hispidum. Tanto P. tuberculatum quanto P. hispidum mostraram grade variedades de compostos.
Associação entre a ingestão de sódio e a rigidez arterial em pacientes com hipertensão arterial sistêmica
Authors: Almeida Cassia Cristina Paes de , Nagano Francisca Eugenia Zaina , Miranda Ana Carolina de , Silva Lannay Ferreira da , Cerci Rodrigo Julio , Lima Júnior Emilton 
Published: June 2022

Rigidez arterial corresponde a parte dos mecanismos atribuídos ao desenvolvimento da hipertensão arterial sistêmica (HAS). Mudanças dos hábitos alimentares são essenciais para o controle da pressão arterial. Entretanto o papel da ingestão de sódio na rigidez arterial de pacientes hipertensos ainda é um tema controverso. O presente trabalho investigou a associação da ingestão de sódio com a rigidez arterial, por meio da Velocidade de Onda de Pulso (VOP). Trata-se de um estudo observacional, transversal realizado de 2018 a 2020. Os pacientes foram analisados conforme presença ou ausência de rigidez arterial, ingestão de sódio (recordatório 24 horas) e sódio urinário. Inicialmente foi realizada a análise da ingestão de sódio como marcador independente de risco para rigidez arterial (velocidade de onda de pulso), sendo ainda conforme as comorbidades existentes [doença renal crônica (DRC) e síndrome metabólica (SM)] e conforme a idade (idosos). Foram incluídos 146 pacientes, 98 (67,2%) pertenciam ao grupo sem rigidez e 48 (32,8%) ao grupo com rigidez arterial. O estudo não demonstrou diferenças estatisticamente relevantes quanto à ingestão de sódio as análises estatísticas entre pacientes com e sem rigidez arterial (p > 0,709). Também não foram observadas diferenças estatísticas quando analisados os grupos por comorbidades (DRC: p > 0,364, SM: p>0,583) e idosos (p>0,192). Neste estudo não foram encontradas diferenças para a ingestão e excreção de sódio entre os grupos com e sem rigidez arterial.
PERANCANGAN SISTEM KEAMANAN PINTU RUANGAN OTOMATIS MENGGUNAKAN RFID BERBASIS INTERNET OF THINGS (IoT)
Authors: Ningrum Nurwijayanti Kusuma , Basyir Abdul 
Published: June 2022

Sistem kunci pintu saat ini masih menggunakan kunci konvensional, sehingga kurang efisien untuk ruang kantor yang masih menggunakan kunci konvensional untuk keamanan ruangan. Sehingga diperlukan kunci yang lebih praktis dan efisien, dari permasalahan tersebut penulis mempunyai ide untuk menghasilkan suatu alat pengaman pintu yang aman dan praktis menggunakan notifikasi. Telegram pada suatu sistem RFID berbasis Internet of things (IoT) sebagai pengaman pintu ruangan . Seiring kemajuan teknologi telekomunikasi khususnya Internet of Things (IoT), menggabungkan alat kunci pintu otomatis dengan teknologi IoT, sehingga perangkat kunci otomatis dapat memantau dan mengontrol secara terus menerus pada jarak tertentu, menggunakan tag RFID pada RFID Reader dan Inframerah (IR). ) sensor sebagai pendeteksi, yang akan memberikan informasi kepada salah satu operator ketika seseorang menggunakan akses pintu. Sistem pada alat ini dapat bekerja dengan baik dan sesuai dengan perintah yang telah dibuat, dengan memberikan informasi rata-rata waktu 4,59 detik saat sistem mengirimkan pesan ke aplikasi Telegram dengan jarak ± 27 KM. Dan ketika sistem akan memberikan akses keluar bagi orang yang berada di dalam ruangan dengan menggunakan sensor infra merah (IR) yang digunakan untuk tombol keluar. Tegangan yang keluar dari digital pin output sensor (IR) stabil sebesar 3,27 V.
Thermophysical Properties of Alkanone + Aromatic Amine Mixtures at Varying Temperatures
Authors: Prabhune Aditi , Natekar Amrita , Dey Ranjan 
Published: June 2022

In the present investigation, an attempt has been made to evaluate internal pressure(Pi), energy(ΔEvap), and enthalpy of vaporization(ΔHvap)along with excess entropy(SE) and excess isothermal compressibility(βTE)for binary solutions of alkanones (2-propanone, 2-butanone, and 2-heptanone) and aromatic amines (aniline, N-methylaniline, and pyridine) at 293.15, 298.15, and 303.15 K, respectively. The cohesive energy density (CED) and solubility parameter(δ)are studied to understand the strength of molecular interactions. The coefficient of thermal expansion(α)and isothermal compressibility(βT)have also been investigated using empirical equations and have been employed to understand the molecular interactions. All the evaluated properties have been used to understand the nature and extent of intermolecular interactions taking place. The observed trends in the properties and their variations have been discussed in terms of varying chain lengths of the alkyl group and the hydrogen bonding capability of the components. The findings show that the extent of interactions follows an order: aniline &gt; NMA &gt; pyridine, keeping the alkanone constant at all the temperatures under study.
Endosulfan Elimination Using Amine-Modified Magnetic Diatomite as an Adsorbent
Authors: Alacabey İhsan 
Published: June 2022

Pesticides are among the most dangerous developing toxins since they are very hazardous to the environment and threaten human health. In this study, researchers successfully manufactured surface-modified magnetic diatomite (m-DE-APTES) and used them as a sorbent to extract endosulfan from an aqueous solution. There is no other study like it in the scholarly literature, and the results are astounding. Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), energy dispersive X-ray (EDX), electron spin resonance (ESR), and surface area measurements were used to analyze magnetic diatomite particles with surface modification. According to the analysis results, magnetic diatomite has a wide surface area and a porous structure. Furthermore, m-DE-APTES has a higher endosulfan adsorption capacity (97.2 mg g−1) than raw diatomite (DE) (16.6 mg g−1). Adsorption statistics agree with Langmuir adsorption isotherm (R2 = 0.9905), and the adsorption occurred spontaneously at −2.576 kj mol−1 in terms of ΔGo. Finally, m-DE-APTES are a viable alternative adsorbent for removing pesticides from aqueous solutions.
Development of a Cleaved Probe-Based Loop-Mediated Isothermal Amplification Assay for Rapid Detection of African Swine Fever Virus
Authors: Wang Songqi , Shen Haiyan , Lin Qijie , Huang Jun , Zhang Chunhong , Liu Zhicheng , Sun Minhua , Zhang Jianfeng , Liao Ming , Li Yugu , Zhang Jianmin 
Published: June 2022

African Swine Fever (ASF), caused by African swine fever virus (ASFV), is a highly contagious and lethal viral disease of pigs. However, commercial vaccines are not yet available, and neither are drugs to prevent or control ASF. Therefore, rapid, accurate on-site diagnosis is urgently needed for detection during the early stages of ASFV infection. Herein, a cleaved probe-based loop-mediated isothermal amplification (CP-LAMP) detection method was established. Based on the original primer sets, we targeted the ASFV 9GL gene sequence to design a probe harboring a ribonucleotide insertion. Ribonuclease H2 (RNase H2) enzyme activity can only be activated when the probe is perfectly complementary, resulting in hydrolytic release of a quencher moiety, and consequent signal amplification. The method displayed robust sensitivity, with copy number detection as low as 13 copies/µL within 40 min at constant temperature (62°C). Visualization of the fluorescence product was employed using a self-designed 3D-printed visualization function cassette, and the CP-LAMP method achieved specific identification and visual detection of ASFV. Moreover, coupling the dual function cassette and smartphone quantitation makes the CP-LAMP assay first user-friendly, cost-effective, portable, rapid, and accurate point-of-care testing (POCT) platform for ASFV.
Comparison of the Efficacy and Safety Endpoints of Five Therapies for Atrial Fibrillation: A Network Meta-Analysis
Authors: Wang Tongyu , Fang Tingting , Cheng Zeyi 
Published: June 2022

IntroductionAtrial fibrillation (AF) is a prevalent arrhythmia that occurs in 2–4% of adults and poses a threat to human health. Thus, comparison of the efficacy and safety of therapies for AF is warranted. Here, we used network analysis to compare efficacy (arrhythmia recurrence and re-hospitalization) and safety (ischemic cerebral vascular events, all-cause mortality, and cardiovascular mortality) endpoints among five major therapies for AF.MethodsThe PubMed, Cochrane, and Embase databases were searched, and relevant literature was retrieved. Only studies that made comparisons among the therapies of interest and involved patients with AF were included. Pairwise comparisons and frequentist method (SUCRA plot) analyses were conducted.ResultsIn total, 62 studies were included in the pooled analysis. In pairwise comparisons, atrioventricular nodal ablation plus permanent pacemaker (AVN + PPM) was associated with a significantly higher risk of atrial arrhythmia recurrence than surgical ablation [odds ratio (OR): 23.82, 95% confidence interval (CI): 1.97–287.59, fixed-effect model; 3.82, 95% CI: 1.01–559.74, random-effects model]. Furthermore, radiofrequency ablation was associated with a significantly lower risk of cardiovascular mortality than medication in pairwise comparison (OR: 0.49, 95% CI: 0.29–0.83, fixed-effect model; OR: 0.49, 95% CI: 0.27–0.9, random-effects model). Frequentist analysis indicated that AVN + PPM had the best performance in reducing the risk of safety and efficacy endpoints.ConclusionNon-pharmaceutical therapies showed superior performance to traditional drug therapy in lowering the risk of safety and efficiency endpoint events. AVN + PPM performed best in reducing the risk of safety and efficacy endpoints.
Awareness and Feasibility of Women Chairing Cardiology Sessions in Scientific Meetings: A Nationwide Survey by the Japanese Circulation Society
Authors: Nakayama Atsuko , Kamiya Chizuko A. , Kanki Sachiko , Ide Tomomi , Bando Yasuko K. , Uemura Yukari , Tsukada Yayoi Tetsuou 
Published: June 2022

BackgroundDiversity and inclusion remain a concern in the field of cardiology. Female cardiologists have less opportunity to chair sessions in scientific meetings than men. However, cardiologists’ awareness and perspectives on feasibility of chairing sessions is poorly understood.Methods and ResultsA web-based survey on awareness regarding the commitment of chairing sessions was sent to 14,798 certificated cardiologists registered with the Japanese Circulation Society (JCS). A total of 3,412 valid responses were obtained, such as 523 women and 2,889 men. Female cardiologists exhibited less interest in serving as chairpersons in Japanese and English sessions (71% women vs. 82% men, p &lt; 0.001, 30% women vs. 40% men, p &lt; 0.001). Influencing factors of chair acceptance in Japanese sessions for female cardiologists were being a cardiologist for over 10 years [odds ratio (OR) 1.84, 95% confidence interval (CI) 1.02–3.33], experience studying abroad (OR 3.35, 95% CI 1.93–5.81) and chairing sessions (OR 8.39, 95% CI 5.48–12.9), having a Doctor of Philosophy (OR 2.82, 95% CI 1.09–7.31), presence of 4 or more female cardiovascular specialists in the hospital (OR 1.70, 95% CI 1.10–2.61) and of role models (OR 2.86, 95% CI 1.93–4.24), and awareness of the JCS chairperson’s manual (OR 10.7, 95% CI 6.67–17.1). The receiver operating characteristic (ROC) curve revealed that the number of female cardiovascular specialists in a hospital was a more sensitive predictor of chair acceptance among male than female cardiologists.ConclusionsFemale cardiologists were less likely to accept chairing sessions compared with male cardiologists and the presence of female cardiovascular specialists positively influenced chair acceptance.
Left Atrial Appendage Mechanical Dispersion Assessed by Speckle-Tracking Echocardiography as a Determinant of Left Atrial Appendage Blood Stasis in Patients With Atrial Fibrillation
Authors: Mao Yankai , Zhao Huajie , Yu Chan , Yang Yuan , Ma Mingming , Wang Yunhe , Jiang Ruhong , Zhao Bowen , Zheng Zhelan , Jiang Chenyang 
Published: June 2022

AimsWe sought to investigate the relationship of left atrial appendage (LAA) mechanical dispersion (MD) with LAA dense spontaneous echo contrast (SEC) or thrombus, and to compare its usefulness in the identification of thrombogenesis with left atrial (LA) MD or LA/LAA strain parameters in patients with atrial fibrillation (AF).MethodsWe conducted a cross-sectional study of 493 consecutive patients with AF [65(58.5–71.0) years, male 66.9%] who underwent echocardiography prior to catheter ablation. We measured the LAA and LA global longitudinal strain (GLS) using speckle-tracking echocardiography (STE). LAA MD and LA MD was defined as the standard deviation (SD) of time to peak positive strain corrected by the R-R interval.ResultsPatients with LAA dense SEC/thrombus (n = 70) had significantly higher LAA MD than controls (n = 423) [median 14.2(11.6–16.8)% vs 9.4(6.2–12.1)%, p &lt; 0.01]. Multivariable analysis showed that LAA MD was independently associated with LAA dense SEC/thrombus in four different models (Odds ratio, 1.23–1.24; p &lt; 0.01), and provided additional diagnostic value over clinical and standard echocardiographic parameters. Whereas, LA MD was not independently associated with LAA dense SEC/thrombus and had no incremental value over other LA/LAA mechanical parameters.ConclusionLAA mechanical dispersion was an independent determinant of LAA dense SEC/thrombus in AF patients, incremental to conventional risk factors and superior to LA mechanical dispersion.
Adverse Effects of Polycystic Ovarian Syndrome on Pregnancy Outcomes in Women With Frozen-Thawed Embryo Transfer: Propensity Score-Matched Study
Authors: Ni Zhexin , Mei Shanshan , You Siting , Lin Yi , Cheng Wen , Zhou Ling , Kuang Yanping , Yu Chaoqin 
Published: June 2022

PurposeThis work aimed to evaluate the adverse effect of polycystic ovary syndrome (PCOS) on pregnancy outcomes of singletons after vitrification in women with frozen-thawed embryo transfer (FET).MethodsPatients with/without PCOS who underwent FET from January 2013 and December 2018 were included. Propensity score matching (PSM) was used to reduce the influence of bias. Logistic regression was applied to identify the risk factors of adverse pregnancy outcomes of singletons in women with PCOS.ResultAfter PSM, the PCOS group had shorter gestational age (P&lt;0.001) and lower newborn birth weight than the non-PCOS group (P=0.045). Compared with the non-PCOS group, the PCOS group had an increased risk of gestational diabetes mellitus (GDM) and pregnancy-induced hypertension (PIH) (P&lt;0.001), placenta and membrane abnormality (P&lt;0.001), stillbirth (P&lt;0.001), neonatal complication (P=0.014), and miscarriage rate (P&lt;0.001). Neonatal complication was associated with parity (adjusted OR=1.202, 95% CI=1.002–1.443, P=0.048) and basal P level (adjusted OR=1.211, 95% CI=1.021–1.436, P=0.028). According to multivariable logistic regression analysis, the miscarriage rate was related to parity (adjusted OR=1.201, 95% CI=1.057–1.166, P=0.005) and basal E2 (adjusted OR=1.002, 95% CI=1.000–1.004, P=0.019) and P levels on the day of embryo transfer (adjusted OR=0.971, 95% CI=0.957–0.985, P&lt;0.001).ConclusionsCompared with non-PCOS women, women with PCOS have a higher risk of GDM and PIH, and neonatal complications and therefore require additional care during pregnancy and parturition.
N7-Methylguanosine Genes Related Prognostic Biomarker in Hepatocellular Carcinoma
Authors: Regmi Parbatraj , He Zhi-Qiang , Lia Thongher , Paudyal Aliza , Li Fu-Yu 
Published: June 2022

Background: About 90% of liver cancer-related deaths are caused by hepatocellular carcinoma (HCC). N7-methylguanosine (m7G) modification is associated with the biological process and regulation of various diseases. To the best of our knowledge, its role in the pathogenesis and prognosis of HCC has not been thoroughly investigated.Aim: To identify N7-methylguanosine (m7G) related prognostic biomarkers in HCC. Furthermore, we also studied the association of m7G–related prognostic gene signature with immune infiltration in HCC.Methods: The TCGA datasets were used as a training and GEO dataset “GSE76427” for validation of the results. Statistical analyses were performed using the R statistical software version 4.1.2.Results: Functional enrichment analysis identified some pathogenesis related to HCC. We identified 3 m7G-related genes (CDK1, ANO1, and PDGFRA) as prognostic biomarkers for HCC. A risk score was calculated from these 3 prognostic m7G-related genes which showed the high-risk group had a significantly poorer prognosis than the low-risk group in both training and validation datasets. The 3- and 5-years overall survival was predicted better with the risk score than the ideal model in the entire cohort in the predictive nomogram. Furthermore, immune checkpoint genes like CTLA4, HAVCR2, LAG3, and TIGT were expressed significantly higher in the high-risk group and the chemotherapy sensitivity analysis showed that the high-risk groups were responsive to sorafenib treatment.Conclusion: These 3 m7G genes related signature model can be used as prognostic biomarkers in HCC and a guide for immunotherapy and chemotherapy response. Future clinical study on this biomarker model is required to verify its clinical implications.
A Recombinant Acetylcholine Receptor α1 Subunit Extracellular Domain Is a Promising New Drug Candidate for Treatment Of Myasthenia Gravis
Authors: Lazaridis Konstantinos , Fernandez-Santoscoy Maria , Baltatzidou Vasiliki , Andersson Jan-Olof , Christison Richard , Grünberg John , Tzartos Socrates , Löwenadler Björn , Fribert Charlotte 
Published: June 2022

Background and AimsMyasthenia gravis (MG) is a T-cell dependent antibody-mediated autoimmune disease in which the nicotinic acetylcholine receptor (AChR) is the major autoantigen, comprising several T and B cell auto-epitopes. We hypothesized that an efficacious drug candidate for antigen-specific therapy in MG should comprise a broad range of these auto-epitopes and be administered in a noninflammatory and tolerogenic context.MethodsWe used a soluble mutated form of the extracellular domain of the α1 chain of the AChR (α1-ECDm), which represents the major portion of auto-epitopes involved in MG, and investigated, in a well-characterized rat model of experimental autoimmune myasthenia gravis (EAMG) whether its intravenous administration could safely and efficiently treat the autoimmune disease.ResultsWe demonstrated that intravenous administration of α1-ECDm abrogates established EAMG, in a dose and time dependent manner, as assessed by clinical symptoms, body weight, and compound muscle action potential (CMAP) decrement. Importantly, the effect was more pronounced compared to drugs representing current standard of care for MG. The protein had a short plasma half-life, most of what could be recovered was sequestered in the liver, kidneys and spleen. Further, we did not observe any signs of toxicity or intolerability in animals treated with α1-ECDm.ConclusionWe conclude that intravenous treatment with α1-ECDm is safe and effective in suppressing EAMG. α1-ECDm is in preclinical development as a promising new drug candidate for MG.