bluuebunny/crossref_metadata_2025_split huggingface dataset:
SMURF2 phosphorylation at Thr249 modifies glioma stemness and tumorigenicity by regulating TGF-β receptor stability
Authors: Hiraiwa Manami , Fukasawa Kazuya , Iezaki Takashi , Sabit Hemragul , Horie Tetsuhiro , Tokumura Kazuya , Iwahashi Sayuki , Murata Misato , Kobayashi Masaki , Suzuki Akane , Park Gyujin , Kaneda Katsuyuki , Todo Tomoki , Hirao Atsushi , Nakada Mitsutoshi , Hinoi Eiichi 
Published: January 2022

AbstractGlioma stem cells (GSCs) contribute to the pathogenesis of glioblastoma, the most malignant form of glioma. The implication and underlying mechanisms of SMAD specific E3 ubiquitin protein ligase 2 (SMURF2) on the GSC phenotypes remain unknown. We previously demonstrated that SMURF2 phosphorylation at Thr249 (SMURF2Thr249) activates its E3 ubiquitin ligase activity. Here, we demonstrate that SMURF2Thr249 phosphorylation plays an essential role in maintaining GSC stemness and tumorigenicity. SMURF2 silencing augmented the self-renewal potential and tumorigenicity of patient-derived GSCs. The SMURF2Thr249 phosphorylation level was low in human glioblastoma pathology specimens. Introduction of the SMURF2T249A mutant resulted in increased stemness and tumorigenicity of GSCs, recapitulating the SMURF2 silencing. Moreover, the inactivation of SMURF2Thr249 phosphorylation increases TGF-β receptor (TGFBR) protein stability. Indeed, TGFBR1 knockdown markedly counteracted the GSC phenotypes by SMURF2T249A mutant. These findings highlight the importance of SMURF2Thr249 phosphorylation in maintaining GSC phenotypes, thereby demonstrating a potential target for GSC-directed therapy.
Apparent stability masks underlying change in a mule deer herd with unmanaged chronic wasting disease
Authors: Fisher Mark C. , Prioreschi Ryan A. , Wolfe Lisa L. , Runge Jonathan P. , Griffin Karen A. , Swanson Heather M. , Miller Michael W. 
Published: January 2022

AbstractThe contagious prion disease “chronic wasting disease” (CWD) infects mule deer (Odocoileus hemionus) and related species. Unchecked epidemics raise ecological, socioeconomic, and public health concerns. Prion infection shortens a deer’s lifespan, and when prevalence (proportion of adults infected) becomes sufficiently high CWD can affect herd dynamics. Understanding population responses over time is key to forecasting long-term impacts. Here we describe unexpected stability in prevalence and abundance in a mule deer herd where CWD has been left unmanaged. High apparent prevalence (~30%) since at least 2005 likely drove observed changes in the proportion and age distribution of wild-type native prion protein (PRNP) gene homozygotes among deer sampled. Predation by mountain lions (Puma concolor) may be helping keep CWD in check. Despite stable appearances, prion disease nonetheless impairs adult survival and likely resilience in this deer herd, limiting its potential for growth despite refuge from hunter harvest and favorable habitat and winter conditions.
InterCellar enables interactive analysis and exploration of cell−cell communication in single-cell transcriptomic data
Authors: Interlandi Marta , Kerl Kornelius , Dugas Martin 
Published: January 2022

AbstractDeciphering cell−cell communication is a key step in understanding the physiology and pathology of multicellular systems. Recent advances in single-cell transcriptomics have contributed to unraveling the cellular composition of tissues and enabled the development of computational algorithms to predict cellular communication mediated by ligand−receptor interactions. Despite the existence of various tools capable of inferring cell−cell interactions from single-cell RNA sequencing data, the analysis and interpretation of the biological signals often require deep computational expertize. Here we present InterCellar, an interactive platform empowering lab-scientists to analyze and explore predicted cell−cell communication without requiring programming skills. InterCellar guides the biological interpretation through customized analysis steps, multiple visualization options, and the possibility to link biological pathways to ligand−receptor interactions. Alongside convenient data exploration features, InterCellar implements data-driven analyses including the possibility to compare cell−cell communication from multiple conditions. By analyzing COVID-19 and melanoma cell−cell interactions, we show that InterCellar resolves data-driven patterns of communication and highlights molecular signals through the integration of biological functions and pathways. We believe our user-friendly, interactive platform will help streamline the analysis of cell−cell communication and facilitate hypothesis generation in diverse biological systems.
Conducting a Community Engagement Studio to Adapt Enhanced Milieu Teaching
Authors: Quinn Emily D. , Cotter Kathleen , Kurin Kim , Brown Kim 
Published: January 2022

Purpose:
Barriers to implementing evidence-based practices occur at various levels. Stakeholder input is required to identify challenges specific to clinical practice settings, client populations, and service delivery approaches. The purpose of this project was to solicit feedback from stakeholders on the telepractice service delivery and implementation strategies proposed for a future study of enhanced milieu teaching (EMT) in rural counties.

Method:
A Community Engagement Studio was conducted with 11 caregivers of children with language delays living in rural counties. Caregivers and the researchers discussed early intervention service delivery for children with language delays in rural Oregon and the proposed telepractice EMT procedures. Researchers gathered feedback on three intervention components: session frequency and schedule, implementation strategies to encourage caregivers' use of EMT, and performance feedback techniques to teach caregivers.

Results:
Findings from the Community Engagement Studio led to four primary modifications to the telepractice EMT study protocol. The principal investigator increased available days and times for intervention sessions and added text-message reminders for parents. A survey was also added for caregivers to identify their preferences for additional implementation strategies (e.g., tip sheets, checklist, e-mailed session summaries) and graphic representations of performance feedback (e.g., bar graph, radial graph, mountain climber infographic).

Conclusion:
Community Engagement Studios are a promising method for increasing community engagement in clinical research and soliciting stakeholder feedback on evidence-based intervention adaptations.

Supplemental Material:

https://doi.org/10.23641/asha.17774819
AGN in the ULIRG HE 0435−5304
Authors: Hryniewicz Krzysztof , Bankowicz Małgorzata , Małek Katarzyna , Herzig Aleksander , Pollo Agnieszka 
Published: January 2022

Context. HE 0435−5304 from Hamburg European Southern Observatory survey is a quasar that appears in the literature with two conflicting redshift values: ∼1.2 and ∼0.4. It was used in the studies of the intergalactic medium through fitting of the narrow absorption lines in its ultraviolet (UV) spectrum. This source is also known historically as a luminous infrared galaxy.
Aims. We present optical spectra of HE 0435−5304, aiming to precisely measure its redshift and to study its physical properties. In particular, properties of its active nucleus, which is studied in the context of the source being identified here as an ultra-luminous infrared galaxy (ULIRG), allow us to place this quasar in the context of the general population.
Methods. We analyzed optical spectra of the quasar HE 0435−5304. Fitting the spectra, we focused on modeling Hβ and [O III] lines. Based on these, we derived the virial black hole mass, bolometric luminosity, and Eddington ratio of the active galactic nucleus (AGN). Additionally, we performed broad band photometry fitting which allows us to quantify host galaxy parameters. Based on available mixed IR/optical/UV data spanning over a decade, we discuss the possible evolution of physical properties of the source and the influence of the observing conditions on our results.
Results. The improved redshift value of HE 0435−5304 is estimated to 0.42788 ± 0.00027 based on the [O II] line – the narrowest line in the spectra – which is mostly consistent with the narrowest components of the other emission lines. The source was found to be a relatively massive and luminous AGN whose host galaxy is actively forming stars. Although its stellar population seems to be heavily obscured, we did not find evidence for significant obscuration of the nucleus. We conclude that the AGN HE 0435−5304 is a rather prominent iron emitter from the extreme type-A population very close to the narrow-line Seyfert 1 group. The fact that the width of the Hβ line appears to be systematically growing in its broadest component with time may suggest that this AGN is changing its broad line region. However, because of the influence of atmospheric effects contaminating spectral profiles, this finding is uncertain.
Asteroid astrometry by stellar occultations: Accuracy of the existing sample from orbital fitting
Authors: Ferreira J. F. , Tanga P. , Spoto F. , Machado P. , Herald D. 
Published: January 2022

Context. The technique of stellar occultations, greatly enhanced by the publication of the Gaia data releases, permits not only the determination of asteroid size and shape, but also the retrieval of additional, very accurate astrometry, with a possible relevant impact on the study of dynamical properties. The use of Gaia as reference catalogue and the recent implementation of an improved error model for occultation astrometry offer the opportunity to test its global astrometric performance on the whole existing data set of observed events, dominated by minor planets belonging to the main belt.
Aims. We aim to explore the performance on orbit accuracy brought by reducing occultations by stellar positions given in Gaia’s Data Release 2 (DR2) and Early Data Release 3 (EDR3), exploited jointly with the new occultation error model. Our goal is to verify that the quality of DR2 and EDR3 provides a logical progression in the exploitation of occultation astrometry with respect to previous catalogues. We also want to compare the post-fit residuals to the error model.
Methods. We began with accurate orbit adjustment to occultation data, either alone or joined to the other available ground-based observations. We then analysed the orbit accuracy and the post-fit residuals.
Results. We find that Gaia EDR3 and DR2 bring a noticeable improvement to the accuracy of occultation data, bringing an average reduction of their residuals upon fitting an orbit of about a factor of 5 when compared to other catalogues. This is particularly visible when occultations alone are used, resulting in very good orbits for a large fraction of objects. We also demonstrate that occultation astrometry can reach the performance of Gaia on small asteroids (5–8 km in the main belt). The joint use of archival data and occultations remains more challenging due to the higher uncertainties and systematic errors of other data, mainly obtained by traditional CCD imaging.
News from the strong interactions program of NA61/SHINE
Authors: Bryliński Wojciech ,   for the NA61/SHINE Collaboration
Published: January 2022

NA61/SHINE (SPS Heavy Ion and Neutrino Experiment) is a fixedtarget experiment operating at the CERN SPS accelerator. The main goal of the strong interactions program of NA61/SHINE is to study the properties of the phase transition between confined matter and quark-gluon plasma by performing a two-dimensional scan in beam momentum and size of collided nuclei. Within this program, collisions of different systems (p+p, p+Pb, Be+Be, Ar+Sc, Xe+La, Pb+Pb) over a wide range of beam momenta (13A-150(8)A GeV/c) have been recorded.
This contribution discusses the latest results of hadron production in p+p, Be+Be, Ar+Sc and Pb+Pb reactions measured by the NA61/SHINE. In particular, the results include charged kaons and pions spectra and higher-order moments of multiplicity and net charge distributions. The presented data are compared with the predictions of different theoretical models as well as the results from other experiments. Finally, the motivation and plans for future NA61/SHINE measurements are discussed.
Laterale Schenkelhalsstressfraktur eines 29-jährigen Marathonläufers – eine seltene und risikobehaftete Überlastungsfraktur des Sportlers
Authors: Gerstmeyer Julius Robert , Godolias Periklis , Mempel Eileen , Bernstorff Maria , Schildhauer Thomas Armin , Königshausen Matthias 
Published: January 2022

ZusammenfassungEin 29-jähriger Leistungssportler beklagte während der Wettkampfvorbereitung seit einer Woche einen dumpfen Hüftschmerz. Während des Wettkampfmarathons musste der Sportler schlussendlich nach 29 Kilometern aufgrund anhaltender Schmerzen den Wettkampf abbrechen. In der anschließenden unmittelbar durchgeführten Diagnostik zeigte sich eine mäßig verschobene laterale Schenkelhalsfraktur. Die Fraktur wurde notfallmäßig operativ mittels dynamischer Hüftschraube versorgt. Wenige Tage später konnte der Patient bei reizlosen Wundverhältnissen die Klinik verlassen. Nach Abschluss der Behandlung konnte er ohne Beeinträchtigungen zum regelmäßigen Training zurückkehren. Zu weiteren Komplikationen kam es nicht. Bei Schmerzen im Bereich der Leiste bzw. lateralen Hüftregion während lang anhaltender läuferischer Belastung muss als Differenzialdiagnose, auch im jungen Alter, eine äußerst seltene Stressfraktur des Schenkelhalses in Betracht gezogen werden. Eine verspätete Diagnostik und Therapie können das Ergebnis nicht nur deutlich verschlechtern, sondern auch das Hüftgelenk insgesamt gefährden.
Insight into Noninvasive Radiological Modalities to Detect Heart Transplant Rejection
Authors: Sharma Dhruva , Subramaniam Ganapathy , Sharma Neha , Sharma Preksha , Sharma Pooja 
Published: January 2022

Abstract
Purpose Patients with end-stage heart failure who remain symptomatic even with exemplary medical and device therapy are treated with heart transplantation. Multitudes of endeavor have been contrived during the last decennium in the field of noninvasive tests to rule out heart transplant rejection (HTR). In spite of having supportive literature, noninvasive imaging techniques lack acceptable documentation of clinical robustness, and endomyocardial biopsy (EMB) still remains the gold standard. The aim of this review is to shed light on the existing noninvasive radiological modalities to detect rejection among heart transplant recipients.
Methods A comprehensive search was conducted for this review article on the basis of literature available including scientific databases of PubMed, Embase, and Google Scholar, using keywords of “Heart transplantation,” “Acute allograft rejection,” “Arrhythmias,” “Echocardiography,” “Speckle tracking echocardiography,” and “Cardiac magnetic resonance imaging” from inception until September 2020.
Results After preliminary screening of the databases, details regarding existent noninvasive radiological modalities to detect HTR were gathered and compiled in this review article. Currently, deformation imaging using speckle tracking and T2 time using cardiac magnetic resonance imaging can serve as screening tools based on which further invasive investigations can be planned. Standardization of blood-based and imaging modalities as screening and possible diagnostic tools for rejection would have obvious clinical and financial benefits in the care of growing number of post heart transplant recipients in our country.
Conclusion Diagnosis of allograft rejection in heart transplant recipients through noninvasive techniques is demanding. To unravel the potential of noninvasive radiological modalities that can serve as a standard-of-care test, a prospective multicentric study randomizing noninvasive modality as first strategy versus current EMB-based gold standard of care is the need of the hour.
Magnetic Resonance Imaging Evaluation of Perinatal Hypoxic Ischemic Encephalopathy: An Institutional Experience
Authors: Reddy Ravikanth 
Published: January 2022

Abstract

Background Hypoxic–ischemic encephalopathy (HIE) is the most commonly diagnosed neurological abnormality affecting children leading to severe neurological deficits and a cause of neonatal mortality. HIE constitutes a diagnostic challenge in the prematurely born and full-term neonates. HIE causes severe neurological deficit in children and many a times goes unnoticed in early stages. The various patterns of central nervous system (CNS) involvement in HIE are dependent on factors, such as severity and duration of hypoxia, and brain maturity in preterm and full-term patients. Magnetic resonance imaging (MRI) has prognostic significance in detecting patterns of HIE secondary to mild-to-moderate and severe hypoxias and the imaging findings are highly dependent on the time at which imaging is done. MRI helps determine the prognosis of brain development in patients with HIE.

Objective This retrospective study elucidates the spectrum of MRI findings in preterm and full-term patients with HIE on MRI.

Materials and Methods This retrospective descriptive study was conducted at a tertiary care center between April 2017 and May 2019 on 50 patients with a clinical diagnosis of HIE using a General Electric (GE) 1.5-Tesla MRI scanner. Various patterns of HIE were evaluated on MRI in preterm and full-term patients.

Results This retrospective study evaluated MRI findings in 50 infants diagnosed with HIE. Eighteen (36%) were preterm and 32 (64%) were full-term patients. Thirty-five (70%) were male and 15 (30%) were female patients. In the current study, developmental delay was the most commonly associated clinical entity in both preterm and full-term patients. In preterm patients, periventricular leukomalacia was the most prevalent MRI finding, and in full-term patients, subcortical and periventricular white matter hyperintensities on T2-weighted and fluid-attenuated inversion recovery (FLAIR) sequences were most commonly encountered.

Conclusion MRI is the primary imaging modality of choice in preterm and full-term patients with HIE, as it helps determine the severity of hypoxic–ischemic injury by understanding the pattern of brain involvement. In the current study, distinguishable patterns of MRI findings secondary to birth asphyxia and ischemic insult were elucidated in both preterm and full-term patients who are highly dependent on the level of brain maturity at the time of imaging. Regular MRI follow-up has a prognostic significance in HIE with accurate prediction of neurodevelopmental outcome on follow-up studies.
A guaranteed immediate payout reduces impatience of financially constrained individuals
Authors: van der Heijden Kimberley , Festjens Anouk , Goukens Caroline , Meyvis Tom 
Published: January 2022

Significance
A wealth of existing findings show that financially constrained individuals are myopic decision-makers who are particularly concerned about the present. We propose that the use of existing intertemporal choice tasks may have skewed our understanding of the decision-making of financially constrained individuals. Specifically, we observe that—as long as an immediate payout is guaranteed—financially constrained individuals are no more myopic than their more affluent counterparts.
Theoretical study of generalized oscillator strengths for the low-lying electronic excitations of CH3Cl and CF3Cl
Authors: Watanabe Noboru , Takahashi Masahiko 
Published: January 2022

Abstract
We report a theoretical study of electronic excitation in CH3Cl and CF3Cl by electron impact. Momentum-transfer-dependent generalized oscillator strengths (GOSs) are calculated for transitions to low-lying excited singlet-states at the equation-of-motion coupled-cluster singles and doubles level. The influence of molecular vibration is taken into account in the calculation. The theoretical results show reasonable overall agreement with experimental data reported in the literature. The shapes of the GOS profiles reveal that the 1 1E state of CH3Cl has a valence-Rydberg mixed nature, while that of CF3Cl is of a predominant C–Cl antibonding character. A comparison with the experimental GOSs of CH3Cl provides unambiguous evidence that the 3pe state is lower in energy than the 3pa1 state. Optical oscillator strengths are also calculated and comparison is made with available experimental and other theoretical results.
Radiation tolerance of GaN: the balance between radiation-stimulated defect annealing and defect stabilization by implanted atoms
Authors: Titov A I , Karabeshkin K V , Struchkov A I , Karaseov P A , Azarov A 
Published: January 2022

Abstract
Realization of radiation-hard electronic devices that are able to work in harsh environments requires deep understanding of the processes of defect formation/evolution occurring in semiconductors bombarded by energetic particles. In the present work we address such intriguing radiation phenomenon as high radiation tolerance of GaN and analyze structural disorder, employing advanced co-irradiation schemes where low and high energy implants with different ions have been used. Channeling analysis revealed that the interplay between radiation-stimulated defect annealing and defect stabilization by implanted atoms dominates defect formation in the crystal bulk. Furthermore, the balance between these two processes depends on implanted species. In particular, strong damage enhancement leading to the complete GaN bulk amorphization was observed for the samples pre-implanted with fluorine ions, whereas the co-irradiation of the samples pre-implanted with such elements as neon, phosphorus and argon leads to a decrease of the bulk damage.
Trivalent ion overcharging on electrified graphene
Authors: Carr Amanda J , Lee Sang Soo , Uysal Ahmet 
Published: January 2022

Abstract
The structure of the electrical double layer (EDL) formed near graphene in aqueous environments strongly impacts its performance for a plethora of applications, including capacitive deionization. In particular, adsorption and organization of multivalent counterions near the graphene interface can promote nonclassical behaviors of EDL including overcharging followed by co-ion adsorption. In this paper, we characterize the EDL formed near an electrified graphene interface in dilute aqueous YCl3 solution using in situ high resolution x-ray reflectivity (also known as crystal truncation rod) and resonant anomalous x-ray reflectivity (RAXR). These interface-specific techniques reveal the electron density profiles with molecular-scale resolution. We find that yttrium ions (Y3+) readily adsorb to the negatively charged graphene surface to form an extended ion profile. This ion distribution resembles a classical diffuse layer but with a significantly high ion coverage, i.e., 1 Y3+ per 11.4 ± 1.6 Å2, compared to the value calculated from the capacitance measured by cyclic voltammetry (1 Y3+ per ∼240 Å2). Such overcharging can be explained by co-adsorption of chloride that effectively screens the excess positive charge. The adsorbed Y3+ profile also shows a molecular-scale gap (⩾5 Å) from the top graphene surfaces, which is attributed to the presence of intervening water molecules between the adsorbents and adsorbates as well as the lack of inner-sphere surface complexation on chemically inert graphene. We also demonstrate controlled adsorption by varying the applied potential and reveal consistent Y3+ ion position with respect to the surface and increasing cation coverage with increasing the magnitude of the negative potential. This is the first experimental description of a model graphene-aqueous system with controlled potential and provides important insights into the application of graphene-based systems for enhanced and selective ion separations.