bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Angiogenesis Effects of Electro-acupuncture Treatment via Exosomal
miR-210 in Cerebral Ischemia-Reperfusion Rats
Authors: Peng Yong-Jun , Xu Shu-Ying , Zeng Chun-Li , Ni Si-Ming 
Published: March 2022

Background:
Acupuncture has been recommended as an alternative and complementary
therapy for preventing and treating cerebral ischemia by the World Health Organization (WHO) for
years. However, the mechanisms remain unclear. Accumulating evidence has shown that acupuncture
can promote angiogenesis to attenuate brain damage after ischemic stroke. In recent years, exosome-
carried microRNAs (miRNAs) activated by acupuncture have proven effective in regulating
pathological changes. We, therefore, investigated whether electro-acupuncture (EA) enhanced angiogenesis
in cerebral stroke via exosome-carried miR-210.

Methods:
We extracted and identified the exosomes from the serum of MCAO with EA treatment
and injected them into MCAO rats for further observation. Simultaneously, miR-120 siRNA and
HIF-1α inhibitor were transfected. Then, we evaluated the volume of infarction, pathological changes,
and expression levels of angiogenic related factors of each group of rats by TTC and HE staining,
transmission electron microscope (TEM), western blot, and quantitative PCR (qPCR).

Results:
Compared with the MCAO group, EA-Exosome (EA-EXO) treatment significantly decreased
the infarct volume and the pathological damage, but miR-210 siRNA or HIF-1α inhibitor
reversed the protective outcomes induced by EA-EXO. Moreover, EA-EXO treatment upregulated
miR-210 and increased CD34, HIF-1α, VEGF, Notch1 protein, and mRNA expressions compared to
the MCAO group. MiR-210 siRNA or HIF-1α inhibitor treatments both down-regulated those angiogenic
related proteins and mRNAs.

Conclusion:
EA treatment could activate the HIF-1α/VEGF/Notch 1 signal pathway to facilitate
angiogenesis after ischemic stroke via exosomal miR-210.
Self-assembled Nucleic Acid Nanostructures for Biomedical Applications
Authors: Chang Xu , Yang Qi , Lee Jungyeon , Zhang Fei 
Published: March 2022

Abstract:
Structural DNA nanotechnology has been developed into a powerful method for creating self-assembled nanomaterials. Their compatibility with biosystems, nanoscale addressability, and programmable dynamic features make them appealing candidates for biomedical research. This review paper focuses on DNA self-assembly strategies and designer nanostructures with custom functions for biomedical applications. Specifically, we review the development of DNA self-assembly methods, from simple DNA motifs consisting of a few DNA strands to complex DNA architectures assembled by DNA origami. Three advantages are discussed using structural DNA nanotechnology for biomedical applications: (1) precise spatial control, (2) molding and guiding other biomolecules, and (3) using reconfigurable DNA nanodevices to overcome biomedical challenges. Finally, we discuss the challenges and opportunities of employing DNA nanotechnology for biomedical applications, emphasizing diverse assembly strategies to create a custom DNA nanostructure with desired functions.
Treatment Management of Diabetic Wounds Utilizing Herbalism: An
Overview
Authors: Sharma Shaweta , Kumari Priya , Sharma Pramod Kumar , Alam Aftab 
Published: March 2022

Background and Objectives:
Diabetes Mellitus, commonly known as DM, is a metabolic
disorder which is characterized by high blood glucose level, i.e., chronic hyperglycemia. If it is not
managed properly, DM can lead to many severe complexities with time and can cause significant damage
to the kidneys, heart, eyes, nerves and blood vessels. Diabetic foot ulcers (DFU) are one of
those major complexities which affect around 15-25% of the population diagnosed with diabetes.
Due to diabetic conditions, the body's natural healing process slows down leading to longer duration
for healing of wounds only when taken care of properly. Herbal therapies are one of the approaches
for the management and care of diabetic foot ulcer, which utilizes the concept of synergism for better
treatment options. With the recent advancement in the field of nanotechnology and natural drug
therapy, a lot of opportunities can be seen in combining both technologies and moving towards a more
advanced drug delivery system to overcome the limitations of polyherbal formulations.

Methods:
During the writing of this document, the data was derived from existing original research
papers gathered from a variety of sources such as PubMed, ScienceDirect, Google Scholar.

Conclusion:
Hence, this review includes evidence about the current practices and future possibilities of
nano-herbal formulation in treatment and management of diabetic wounds.
The Value of Ultrasonography in Predicting Acute Gangrenous Cholecystitis
Authors: Peng Yanhui , Liu Yifan , Xue Dongdong 
Published: March 2022

Abstract:
Acute cholecystitis is a common clinical inflammatory lesion of the gallbladder. With the
aggravation of inflammation, ischemic, necrosis, and even acute gangrenous cholecystitis occur in the
gallbladder. At the same time, a variety of complications appear, seriously affecting the prognosis of
patients. It is recommended that ultrasound can be utilized as the first choice for the diagnosis of acute
cholecystitis, due to its fastness, convenience, non-radiation, and low cost. Here, we summarize the
latest progress that can predict acute gangrenous cholecystitis in ultrasound, thus assisting us in identifying
patients with high risk of gangrene in early stage, and treating these patients in time.
Current Progress and Perspectives of CDC20 in Female
Reproductive Cancers
Authors: Ni Ke , Hong Li 
Published: March 2022

Abstract:
The cancers of the cervix, endometrium, ovary, and breast are great threats
to women’s health. Cancer is characterized by the uncontrolled proliferation of cells and
deregulated cell cycle progression is one of the main causes of malignancy. Agents
targeting cell cycle regulators may have potential anti-tumor effects. CDC20 (cell division
cycle 20 homologue) is a co-activator of the anaphase-promoting complex/cyclosome
(APC/C) and thus acts as a mitotic regulator. In addition, CDC20 serves as a subunit of
the mitotic checkpoint complex (MCC) whose function is to inhibit APC/C. Recently,
higher expression of CDC20 has been reported in these cancers and was closely
associated with their clinicopathological parameters, indicating CDC20 a potential target
for cancer treatment that is worth further study. In the present review, we summarized
current progress and put forward perspectives of CDC20 in female reproductive
cancers.
The Protective Effects of the Combination of Vitamin E and Swimming Exercise on Memory Impairment Induced by Exposure to Waterpipe Smoke
Authors: Alzoubi Karem H. , Halboup Abdulsalam M. , Khabour Omar F. , Alomari ⁠ Mahmoud A. 
Published: March 2022

Background:Waterpipe smoking (WP) exposure involves a negative health impact, including memory deficit, which is attributed to the elevation of oxidative stress. Vitamin E (VitE) in combination with swimming exercise exerts protective effects that prevent memory impairment. In the current study, the modulation of WP-induced memory impairment by the combined effect of VitE and swimming exercise (SE) was investigated.Method:Animals were exposed to WP one hour/day, five days per week for four weeks. Simultaneously, VitE (100 mg/kg, six days/week for four weeks) was administered via oral gavage, and the rats were made to swim one hour/day, five days/week for four weeks. Changes in memory were evaluated using radial arm water maze (RAWM), and oxidative stress biomarkers were examined in the hippocampus.Results:WP exposure induced short-term/long-term memory impairment (p<0.05). This impairment was prevented by a combination of VitE with SE (p<0.05). Additionally, this combination normalized the hippocampal catalase, GPx, and GSH/GSSG ratios that were modulated by WP (p<0.05). The combination further reduced TBARs levels below those of the control group (p<0.05).Conclusion:WP-induced memory impairments were prevented by the combination of VitE with SE. This could be attributed to preserving the hippocampal oxidative mechanism by combining VitE and SE during WP exposure.
Vaccine Efficacy Denial: A Growing Concern Affecting Modern Science,
and Impacting Public Health
Authors: Signorini Luca , Ceruso Francesco Maria , Aiello Elisabetta , Zullo Maria Josephine , De Vito Danila 
Published: March 2022

Background:
The discovery of the vaccination technique was revealed by Edward Jenner in 1796, which represented the first scientific attempt to control an infectious disease by vaccines, followed by other important studies carried out by Pasteur and Koch, and Sabin, who developed the first technique to attenuate the virus. In recent decades, numerous scholars have begun to create dangerous theories against the effectiveness of vaccines through scientifically invalid or fraudulent studies.

Aim:
This critical review of the literature aims to analyze the main factors that have undermined the credibility of vaccines in the general population, disproved false information and emphasized the benefits of vaccines over the last 200 years.

Discussions:
Unfortunately, several studies have been carried out without the proper scientific attention. The most impacting example is the study published by Andrew Wakefield in the Lancet journal who tried to correlate vaccines with the development of autism: this publication was withdrawn from the journal a few years after its publication, but the impact of incorrect scientific studies, fake news, and ambiguous healthcare policies have led to a general adverse opinion about the effectiveness of vaccines.

Conclusion:
The excess of uncontrolled information is a serious concern during the Coronavirus pandemic. Modern science must tackle this problem with a better willingness to communicate the clinical studies to those who cannot understand medical information. Nevertheless, a reliable science must also limit the distribution of studies that do not meet the basic criteria of methodological rigor and certainty of results in order not to incur confusion in the scientific community.
Recent Advances on Anti-interference Control Strategies for Better Operation
Authors: Gao Bingwei , Ye Yongtai , Guan Hao , Sheng Wei 
Published: March 2022

Background:
Under the influence of complex external environment and the internal parameter
perturbation of the system itself, many interference problems hinder the development of the
controlled object according to the predetermined trajectory.

Objective:
The objective of this study is to provide the corresponding anti-interference control
methods for different degrees of interference and introduce their respective characteristics.

Methods:
This paper mainly summarizes the application examples of anti-interference control algorithms
in the face of different interference problems, which are mainly divided into three categories.
Especially two new concepts, whose names are composite anti-interference control and innovative
anti-interference control algorithm design, are presented. At the same time, this paper not only
summarizes the outstanding contribution of anti-interference control in the mechanical field, but
also expounds on the application examples of coupling of anti-interference control in electrical aspect
and describes the application of anti-interference control in other planets.

Results:
From the interference problem on the earth to the anti-interference control of outer space,
the control algorithm shows the unique charm step by step. In the future, to cope with the complex
and changeable environment, the anti-interference algorithm will continue to be optimized in depth,
letting the control system run steadily in direction of fast, accurate and stable on the expected track.

Conclusion:
Anti-interference control plays an important practical role in the control of systems.
Whether in the mechanical field or coupling in other aspects such as electrical, it can help the system
run better according to the needs of the controller. It is effective and reasonable to combine different
strategies for the systems, so that the systems are more accurate and stable.
Determining the Optimal Virtual Reality Exergame Approach for Balance Therapy in Persons With Neurological Disorders Using a Rasch Analysis: Longitudinal Observational Study
Authors: Wiskerke Evelyne , Kool Jan , Hilfiker Roger , Sattelmayer Karl Martin , Verheyden Geert 
Published: March 2022

Background
Virtual reality (VR) exergames have gained popularity in the rehabilitation of persons with neurological disorders as an add-on therapy to increase intensity of training. Intensity is strongly dependent on the motivation of the patient. Motivation can be increased by delivering variation within training and challenging exercises. However, patients are often underchallenged, as exergame difficulty often does not match the patient’s ability. A Rasch analysis can establish hierarchy of exergame items in order to assist the delivery of patient-centered therapy.

Objective
The aim of this study was to apply the Rasch model to create a hierarchical order of existing VR balance exergames and to relate these exergames to the abilities of persons with neurological disorders, in order to deliver challenge and variation.

Methods
A total of 30 persons with stroke and 51 persons with multiple sclerosis (MS) were included in the study. All participants performed a training program, lasting 3 weeks for persons with MS and 4 weeks for persons with stroke, in which they performed VR balance exergames with a movement recognition–based system (MindMotion GO; MindMaze SA). VR exercise scores, Berg Balance Scale scores, and clinical descriptive data were collected. Berg Balance Scale and device scores were analyzed with the Rasch model using a repeated-measures approach to examine whether the distribution of exercise scores fitted the Rasch model. Secondly, a person-item map was created to show the hierarchy of exercise difficulty and person ability.

Results
Participants completed a selection of 56 balance exercises (ie, items), which consisted of a combination of various balance tasks and levels (ie, exercises). Using repeated measures, this resulted in a count of 785 observations. Analysis showed strong evidence for unidimensionality of the data. A total of 47 exercises (ie, items) had a sufficiently good fit to the Rasch model. Six items showed underfit, with outfit mean square values above 1.5. One item showed underfit but was kept in the analysis. Three items had negative point-biserial correlations. The final model consisted of 47 exercises, which were provided for persons with low to moderate balance ability.

Conclusions
The VR exercises sufficiently fitted the Rasch model and resulted in a hierarchical order of VR balance exercises for persons with stroke and MS with low to moderate balance ability. In combination with the Berg Balance Scale, the results can guide clinical decision-making in the selection of patient-focused VR balance exercises.

Trial Registration
ClinicalTrials.gov NCT03993275; https://clinicaltrials.gov/ct2/show/NCT03993275
Natural Language Processing to Identify Digital Learning Tools in Postgraduate Family Medicine: Protocol for a Scoping Review
Authors: Yan Hui , Rahgozar Arya , Sethuram Claire , Karunananthan Sathya , Archibald Douglas , Bradley Lindsay , Hakimjavadi Ramtin , Helmer-Smith Mary , Jolin-Dahel Kheira , McCutcheon Tess , Puncher Jeffrey , Rezaiefar Parisa , Shoppoff Lina , Liddy Clare 
Published: March 2022

Background
The COVID-19 pandemic has highlighted the growing need for digital learning tools in postgraduate family medicine training. Family medicine departments must understand and recognize the use and effectiveness of digital tools in order to integrate them into curricula and develop effective learning tools that fill gaps and meet the learning needs of trainees.

Objective
This scoping review will aim to explore and organize the breadth of knowledge regarding digital learning tools in family medicine training.

Methods
This scoping review follows the 6 stages of the methodological framework outlined first by Arksey and O’Malley, then refined by Levac et al, including a search of published academic literature in 6 databases (MEDLINE, ERIC, Education Source, Embase, Scopus, and Web of Science) and gray literature. Following title and abstract and full text screening, characteristics and main findings of the included studies and resources will be tabulated and summarized. Thematic analysis and natural language processing (NLP) will be conducted in parallel using a 9-step approach to identify common themes and synthesize the literature. Additionally, NLP will be employed for bibliometric and scientometric analysis of the identified literature.

Results
The search strategy has been developed and launched. As of October 2021, we have completed stages 1, 2, and 3 of the scoping review. We identified 132 studies for inclusion through the academic literature search and 127 relevant studies in the gray literature search. Further refinement of the eligibility criteria and data extraction has been ongoing since September 2021.

Conclusions
In this scoping review, we will identify and consolidate information and evidence related to the use and effectiveness of existing digital learning tools in postgraduate family medicine training. Our findings will improve the understanding of the current landscape of digital learning tools, which will be of great value to educators and trainees interested in using existing tools, innovators looking to design digital learning tools that meet current needs, and researchers involved in the study of digital tools.

Trial Registration
OSF Registries osf.io/wju4k; https://osf.io/wju4k

International Registered Report Identifier (IRRID)
DERR1-10.2196/34575
PEMBERDAYAAN KADER DASAWISMA DALAM PENGELOLAAN SAMPAH RUMAH TANGGA DENGAN METODE KERANJANG TAKAKURA
Authors: Hegard Sukmawati (Scopus ID: 57189732715) Ni Made , Pratiwi Anny Eka , Juwita DAP Ratna 
Published: March 2022

Kesehatan dan sampah merupakan dua hal yang tidak dapat dipisahkan. Sampah identik dengan sesuatu yang kotor dan berbau busuk. Penumpukan sampah dapat menimbulkan pencemaran air dan tanah, serta menimbulkan masalah sanitasi lainnya. Sanitasi buruk merupakan media yang tepat bagi perkembangbiakan pathogen maupun vektornya sehingga berpotensi menjadi sumber munculnya kejadian penyakit menular. Partisipasi masyarakat merupakan salah satu faktor penting dalam memecahkan permasalahan sampah, karena keberhasilan dalam pengelolaan sampah terletak pada kontribusi partisipasi masyarakatnya. Sebual merupakan sebuah banjar yang berada di wilayah Kecamatan Jembrana, Kabupaten Jembrana, Bali. Banjar Sebual berlokasi di perbatasan kota kabupaten dan dilewati oleh jalan provinsi. Masyarakat di wilayah ini masih mengelola sampah dengan cara penimbunan di pekarangan, pembakaran, dan bahkan diantaranya melakukan pembuangan sampah ke sungai. Tujuan kegiatan pengabdian masyarakat (PKM) ini adalah untuk meningkatkan pengetahuan masyarakat mengenai kesehatan lingkungan dan memberikan pembekalan mengenai teknik pengolahan sampah rumah tangga dengan metode sederhana, yaitu komposting Takakura. Metode pelaksanaan kegiatan ini terbagi menjadi tiga tahap, persiapan, pelaksanaan, dan evaluasi. Pelaksanaan kegiatan meliputi pemaparan materi melalui presentasi, penayangan video peraga, dan demonstrasi langsung pengolahan sampah rumah tangga dengan komposting Takakura. Rancangan evaluasi kegiatan meliputi evaluasi kehadiran, partisipasi aktif kader, membandingkan pengetahuan dan kemampuan kader dalam pengelolaan sampah melalui pre-test dan post-test, serta evaluasi kepuasan kader terhadap keberlanjutan program. Program PKM ini telah berjalan dengan lancar dan peserta telah memiliki pengetahuan yang cukup untuk melakukan pengolahan sampah rumah tangga dengan metode komposting keranjang Takakura. Hasil evaluasi terhadap pengetahuan peserta menunjukkan kenaikan skor pengetahuan dari rerata 27.5 (pre-test) dan terjadi kenaikan skor rerata menjadi 90.0 (post test). Evaluasi terhadap kepuasan peserta terhadap keberlangsungan program dilakukan secara kualitatif melalui dialog dan secara umum peserta menyatakan puas dengan kegiatan ini dan menyatakan telah memberikan pengetahuan baru bagi peserta.
Covid-19: A Pharmacotherapeutic Perspective
Authors: Khan Bushra Hasan , Singh Shivangna , Ahmad Jameel , Ahmad Farida 
Published: March 2022

Introduction: COVID-19 disease has been difficult to tackle owing to the lack of typical therapeutic options. Many antivirals, antimalarial, and biologics are being carefully evaluated for treatment. This literature analysis aims to shed light to the ongoing studies concerning treatment possibilities for COVID-19 and assist as a reserve for health experts.
Objectives: This literature review was done to underline the efficacy and safety of existing treatment alternatives for COVID-19 and the cautious use of non-steroidal anti-inflammatory drugs, angiotensin-converting enzyme inhibitors and angiotensin receptor blockers.
Methods: PubMed, Medline, Embase and SCOPUS were meticulously browsed utilizing an amalgamation of the keywords "COVID 19," "SARS-CoV-2," and "treatment." All categories of articles together with clinical guidelines, case-studies and systematic reviews were assessed.
Conclusions: Treatments that unswervingly target SARS-CoV-2 are not present so far; however, several antivirals (Remdesivir) and antimalarials (Hydroxychloroquine) have appeared as valuable treatment possibilities. Remdesivir and convalescent plasma may be expected to play a beneficial role in serious patients with respiratory failure. Interleukin-6 (IL-6) antagonists could also be utilized in patients who progress and display evidence of cytokine release syndrome. Corticosteroids need to be avoided lest there is a gripping indication for their usage. Available evidence for prevention and treatment of COVID-19 must be utilized till recognized treatments are derived into reality.