bluuebunny/crossref_metadata_2025_split huggingface dataset:
Diving ergospirometry with suspended weights: breathing- and fin-swimming style matter
Authors: Koch Andreas , Kramkowski Dennis , Holzum Mattes , Kähler Wataru , Klapa Sebastian , Rieger Bente , Weisser Burkhard , Schipke Jochen D. 
Published: August 2022

Abstract
Purpose
Scuba diving is a complex condition including elevated ambient pressure, limited air supply, increased breathing work, and unfamiliar fin-swimming. Earlier approaches to assess diving specific data did not comprehensively address these aspects. We first present an underwater ergospirometry system and then test the hypothesis that both breathing characteristics and fin-swimming style affect the air consumption.

Methods/Participants
A suspended-weights ergospirometry system was mounted inside a hyperbaric chamber. Ergo group: 25 divers (24.6 ± 4.1 years); three set-ups: dry normobaric cycling (75–225 W), dry cycling at 20 m simulated depth (75–225 W), fin-swimming at 20 m (5–8 kg suspended weights). Style group: 20 other divers (24.6 ± 4.1 years): fin-swimming at 20 m (5–8 kg) with regard to ventilation ($$\dot{V}$$

V
˙

E) and fin-swimming style.

Results
Ergo group: linear heart rate and oxygen uptake ($$\dot{V}$$

V
˙

O2) increases with both 50 W-bicycle steps and suspended-weights ergometry (r = 0.97). During hyperbaric conditions, $$\dot{V}$$

V
˙

E was less increased versus normobaric conditions. Style group: the more efficient hip/thigh-oriented style shifted towards the knee/calf-oriented style. $$\dot{V}$$

V
˙

E and $$\dot{V}$$

V
˙

O2 were higher in beginners (< 100 dives) versus advanced divers (≥ 100 dives). Significant differences on the 5 kg-step: $$\dot{V}$$

V
˙

E: 31.5 ± 7.1 l/min vs. 23.7 ± 5.9 l/min and $$\dot{V}$$

V
˙

O2: 1.6 ± 0.3 l/min vs. 1.2 ± 0.3 l/min. A comparison is presented, in addition to illustrate the impact of differences in breathing characteristics and fin-swimming style.

Conclusions
Diving ergospirometry with suspended weights in a hyperbaric chamber allows for comprehensive studies. Little diving experience in terms of breathing characteristics and fin-swimming style significantly increases $$\dot{V}$$

V
˙

E thereby increasing the risk of running-out-of-air.
Usefulness of CT scan as part of an institutional protocol for proactive leakage management after low anterior resection for rectal cancer
Authors: Talboom K. , van Helsdingen C. P. M. , Abdelrahman S. , Derikx J. P. M. , Tanis P. J. , Hompes R. 
Published: August 2022

AbstractPurposeHighly selective fecal diversion after low anterior resection (LAR) for rectal cancer requires a strict postoperative protocol for early detection of anastomotic leakage (AL). The purpose of this study was to evaluate C-reactive protein (CRP)–based CT imaging in diagnosis and subsequent management of AL.MethodsAll patients that underwent a CT scan for suspicion of AL after transanal total mesorectal excision for rectal cancer in a university center (2015–2020) were included. Outcome parameters were diagnostic yield of CT and timing of CT and subsequent intervention.ResultsForty-four out of 125 patients underwent CT (35%) with an overall median interval of 5 h (IQR 3–6) from CRP measurement. The anastomosis was diverted in 7/44 (16%). CT was conclusive or highly suspicious for AL in 23, with confirmed AL in all those patients (yield 52%), and was false-negative in one patient (sensitivity 96%). CT initiated subsequent intervention after median 6 h (IQR 3–25). There was no or minor suspicion of AL on imaging in all 20 patients without definitive diagnosis of AL. After CT imaging on day 2, AL was confirmed in 0/1, and these proportions were 6/6 for day 3, 7/10 for day 4, 2/4 for day 5, and 9/23 beyond day 5.ConclusionIn the setting of an institutional policy of highly selective fecal diversion and pro-active leakage management, the yield of selective CT imaging using predefined CRP cut-off values was 52% with a sensitivity of 96%, enabling timely and tailored intervention after a median of 6 h from imaging.
Asparagus officinalis combined with paclitaxel exhibited synergistic anti-tumor activity in paclitaxel-sensitive and -resistant ovarian cancer cells
Authors: Zhang Xin , Wang Jiandong , Fan Yali , Zhao Ziyi , Paraghamian Sarah E. , Hawkins Gabrielle M. , Buckingham Lindsey , O’Donnell Jillian , Hao Tianran , Suo Hongyan , Yin Yajie , Sun Wenchuan , Kong Weimin , Sun Delin , Zhao Luyu , Zhou Chunxiao , Bae-Jump Victoria L. 
Published: August 2022

Abstract
Purpose
Although paclitaxel is a promising first-line chemotherapeutic drug for ovarian cancer, acquired resistance to paclitaxel is one of the leading causes of treatment failure, limiting its clinical application. Asparagus officinalis has been shown to have anti-tumorigenic effects on cell growth, apoptosis, cellular stress and invasion of various types of cancer cells and has also been shown to synergize with paclitaxel to inhibit cell proliferation in ovarian cancer.

Methods
Human ovarian cancer cell lines MES and its PTX-resistant counterpart MES-TP cell lines were used and were treated with Asparagus officinalis and paclitaxel alone as well as in combination. Cell proliferation, cellular stress, invasion and DMA damage were investigated and the synergistic effect of a combined therapy analyzed.

Results
In this study, we found that Asparagus officinalis combined with low-dose paclitaxel synergistically inhibited cell proliferation, induced cellular stress and apoptosis and reduced cell invasion in paclitaxel-sensitive and -resistant ovarian cancer cell lines. The combined treatment effects were dependent on DNA damage pathways and suppressing microtubule dynamics, and the AKT/mTOR pathway and microtubule-associated proteins regulated the inhibitory effect through different mechanisms in paclitaxel-sensitive and -resistant cells.

Conclusion
These findings suggest that the combination of Asparagus officinalis and paclitaxel have potential clinical implications for development as a novel ovarian cancer treatment strategy.
The incidence of severe oral mucositis in patients undergoing different conditioning regimens in haematopoietic stem cell transplantation
Authors: Nakagaki Midori , Kennedy Glen A. , Gavin Nicole C. , Clavarino Alexandra , Whitfield Karen 
Published: August 2022

Abstract
Purpose
Oral mucositis is a common complication during haematopoietic stem cell transplantation (HSCT). This study aimed to assess the incidence of severe mucositis in patients undergoing different HSCT regimens.

Methods
This single-centre retrospective study reviewed daily oral assessment for 467 consecutive patients who underwent different transplant regimens for matched unrelated or related allogeneic HSCT with post-transplant methotrexate, haploidentical or mismatched HSCT with post-transplant cyclophosphamide (PTCy), or autologous HSCT. Oral care and cryotherapy with melphalan were used. Patient demographic data, oral mucositis WHO grade, use of total parenteral nutrition (TPN) and patient-controlled analgesia (PCA) were collected.

Results
Grade 3–4 oral mucositis was common in myeloablative total body irradiation (TBI)-based regimens cyclophosphamide/ TBI (CyTBI) (71%) and fludarabine/ TBI (FluTBI) with PTCy (46%), as well as reduced-intensity fludarabine/melphalan (FluMel) (43%) and carmustine/etoposide/cytarabine/melphalan (BEAM) autologous HSCT (41%). In contrast, grade 3–4 oral mucositis was less common in reduced-intensity haploidentical regimen melphalan/fludarabine/TBI with PTCy (19%), all non-myeloablative regimens (0–9%) and high-dose melphalan autologous HSCT (26%). TPN and PCA use were correlated to oral mucositis severity.

Conclusions
Severe oral mucositis was associated with myeloablative TBI, methotrexate and melphalan in combination with methotrexate and in BEAM. Use of PTCy was preferable over methotrexate to prevent oral mucositis.
Symmetry and monotonicity results for solutions of semilinear PDEs in sector-like domains
Authors: Gladiali Francesca , Greco Antonio 
Published: August 2022

AbstractIn this paper we consider semilinear PDEs, with a convex nonlinearity, in a sector-like domain. Using cylindrical coordinates $$(r, \theta , z)$$

(
r
,
θ
,
z
)

, we investigate the shape of possibly sign-changing solutions whose derivative in $$\theta$$
θ
vanishes at the boundary. We prove that any solution with Morse index less than two must be either independent of $$\theta$$
θ
or strictly monotone with respect to $$\theta$$
θ
. In the special case of a planar domain, the result holds in a circular sector as well as in an annular one, and it can also be extended to a rectangular domain. The corresponding problem in higher dimensions is also considered, as well as an extension to unbounded domains. The proof is based on a rotating-plane argument: a convenient manifold is introduced in order to avoid overlapping the domain with its reflected image in the case where its opening is larger than $$\pi$$
π
.
Formal and relational governance of artificial intelligence outsourcing
Authors: Beulen Erik , Plugge Albert , van Hillegersberg Jos 
Published: August 2022

AbstractOutsourcing emerging technologies such as Artificial Intelligence (AI) are expected to impact organisations significantly, due to a tight labour market for AI expertise. However, how formal and relational governance effects Information Systems suppliers who provide AI services has not been studied. Based on an exploratory research amongst eight suppliers and two market research advisors, we conducted 18 expert interviews and found evidence how formal contractual and relational governance affects AI outsourcing. The results indicate various forms of contractual models in which some cater for clients’ needs specifically, e.g. outcome-based, experience-driven Service Level Agreements (SLAs). Our examination provides insights that formal and relational Information Systems (IS) outsourcing governance are complementary in cases where clients and suppliers co-develop AI. For our research, we adapted the outsourcing governance model of Lioliou et al. (Inf Syst J 24:503–535, 2014), including their emphasis on the psychological contract. We contribute to IS outsourcing literature by exploring, beyond contract management insights, differences between suppliers in providing AI services. Our study acknowledges that AI outsourcing shift the emphasis from a transactional type of arrangement to a relational type of outsourcing arrangement. In addition, the combination of both formal and relational governance mechanisms positively contributes to IS governance. Our study also confirms that the innovative character of AI positively contributes to the psychological contract in outsourcing AI.
Regenerative agriculture and a more-than-human ethic of care: a relational approach to understanding transformation
Authors: Seymour Madison , Connelly Sean 
Published: August 2022

AbstractA growing body of literature argues that achieving radical change in the agri-food system requires a radical renegotiation of our relationship with the environment alongside a change in our thinking and approach to transformational food politics. This paper argues that relational approaches such as a more-than-human ethic of care (MTH EoC) can offer a different and constructive perspective to analyse agri-food system transformation because it emphasises social structures and relationships as the basis of environmental change. A MTH EoC has not yet been applied to regenerative agriculture, yet other literature on regenerative agriculture suggests that care may be present in these spaces and calls for the need for social science analysis of the regenerative movement. This paper uses a MTH EoC lens to reveal a diverse array of ways in which power is and can be deployed for change in the regenerative agriculture movement in Aotearoa, New Zealand. Globally, regenerative agriculture tends to be analysed through positivist, scientific approaches that focus on biophysical markers of ecological improvement. Yet, a relational approach reveals how engagement in regenerative agriculture is creating significant shifts in mindset towards more holistic and relational understandings of biological and social ecosystems. A regenerative mindset framework is suggested as a method of understanding the connection between a regenerative form of thinking, being and doing for farmers. Interviews suggested that this shift in farmers’ socio-ecological relations is crucial to the transformational potential of regenerative agriculture. This paper argues that relational analyses such as the MTH EoC approach used to analyse regenerative agriculture in this research, refresh the way we analyse agri-food system change. They also are critical to guiding and supporting on-the-ground socio-ecological shifts that are necessary to see agricultural transformation.
Listeria monocytogenes is a solvent tolerant organism secreting a solvent stable lipase: potential biotechnological applications
Authors: Priyanka Priyanka , Kinsella Gemma K. , Henehan Gary T. , Ryan Barry J. 
Published: August 2022

Abstract
Purpose
The emerging biobased economy will require robust, adaptable, organisms for the production and processing of biomaterials as well as for bioremediation. Recently, the search for solvent tolerant organisms and solvent tolerant enzymes has intensified. Resilient organisms secreting solvent stable lipases are of particular interest for biotechnological applications.

Methods
Screening of soil samples for lipase-producing organisms was carried out on Rhodamine B plates. The most productive lipase-producing organisms were further screened for their resistance to solvents commonly used in biotechnological applications.

Results
In the course of screening, one of the isolated organisms that exhibited extracellular lipase activity, was identified as the human pathogen Listeria monocytogenes through 16S rRNA sequencing. Further exploration revealed that this organism was resistant to solvents ranging from log P − 0.81 to 4.0. Moreover, in the presence of these solvents, L. monocytogenes secreted an extracellular, solvent tolerant, lipase activity. This lipase retained approximately 80% activity when incubated in 30% (v/v) methanol for 24 h.

Conclusion
These findings identify L. monocytogenes as a potentially useful organism for biotechnological applications. However, the fact that Listeria is a pathogen is problematic and it will require the use of non-pathogenic or attenuated Listeria strains for practical applications. Nonetheless, the ability to adapt to rapidly changing environmental conditions, to grow at low temperatures, to resist solvents and to secrete an extracellular solvent tolerant lipase are unique and highly useful characteristics. The potential application of L. monocytogenes in wastewater bioremediation and plastics degradation is discussed.
Mapping interactions between sustainable development and heatwave resilience
Authors: Nunes Ana Raquel 
Published: August 2022

AbstractUrgent action is needed to ensure the achievement of the sustainable development goals (SDGs) by 2030. Under climate change the intensity and frequency of heatwaves are projected to increase and urgent action is also needed to improve heatwave resilience now and in the future. Yet, it remains unclear how countries are planning and implementing policies and actions for this to happen. Interactions between the SDGs have been widely researched. However, little is known about the interactions between the SDGs and heatwave resilience. In response, this study focuses on mapping such interactions. This mixed methods study design with a diverse group of stakeholders from different sectors of society identified key interactions, sources of interactions and solutions for achieving both agendas. The analysis revealed that: (i) synergies largely outweigh trade-offs; (ii) a broad compatibility exists between the two agendas; (iii) no fundamental incompatibilities were found, and; (iv) the two agendas are not being consistently aligned. These findings are essential for parallel and effective achievement of both agendas and to enhance synergies and reduce trade-offs. A series of solutions were identified which can be implemented. Such integrated approaches would enhance success and overall performance by improving collaborations, using common language, regulation and planning, pooling resources, skills, inclusive information and translation to practice.
Can There Be a Recourse to a Philosophy of Love? A Confronting Question at the Heart of a Poor Pedagogy
Authors: Orih Dominic 
Published: August 2022

AbstractThe question of love and its place in pedagogy has brought diverging views and disagreement. It would appear to be creating more problems than it solves. On one hand, the contention lies on the discussion of love as something extraneous to our being by using an either-or approach. On the other hand, it lies on the understanding of love as something bereft in our shared human experience especially in moments of suffering. These problematic approaches have led to disagreements among those who subscribe to the place of love in pedagogy and those who propose that love does not have any place in education. I hereby propose an alternative approach; one that encourages willing the good of the other for the other. If all educational endeavours and all the opposing positions on love and its place in pedagogy is done based on promoting the good of the other, then love is essentially and existentially integral in education because love is for the good of the other. This became apparent to me through a ‘poor pedagogy’ that opened the door for a transformative learning curve. I explored this insight philosophically through a discussion of the Socratic way that shaped the ancient Greeks’ understanding of love and education. I relate this understanding to my personal teaching experience and then examine the implication of love for education as something that influences positively the educational experience of both teachers and students in their pursuit of the highest good, manifesting in the reward of love as love.
Numerical modelling of the KOBO extrusion process using the Bodner–Partom material model
Authors: Wójcik Marta , Skrzat Andrzej 
Published: August 2022

AbstractNumerical simulations of the extrusion process assisted by die cyclic oscillations (KOBO extrusion) is presented in this paper. This is highly non-linear coupled thermo-mechanical problem. The elastic-viscoplastic Bodner–Partom-Partom material model, assuming plastic and viscoplastic effects in a wide range of strain rates and temperatures, has been applied. In order to perform simulations, the user material procedure for B–P material has been written and implemented in the commercial FEM software. The coupled Eulerian–Lagrangian method has been used in numerical computations. In CEL method, explicit integration of the constitutive equations is required and remeshing is not necessary even for large displacements and large strains analyses. The results of numerical simulations show the heterogeneous distribution of stress and strain inside container and the non-uniform distribution of strain in the extruded material. The increase of material temperature has been noted. The results obtained (stress, temperature, location of plastic zones) qualitatively confirm the results of experimental investigations. The application of the user material procedure allows accessing all material state variables (current yield stress, hardening parameters, etc.), and therefore it gives detailed information about phenomena occurring in extruded material inside recipient. This information is useful for a proper selection of parameters of the KOBO extrusion process e.g. synchronization of the punch displacement with the die oscillations frequency to avoid the saturation of material isotropic hardening, which blocks the progress of extrusion.
Performance analysis of hybrid free space optical and visible light communications for underwater applications using spatial diversity
Authors: Zakaria Islam , Abaza Mohamed , Fedawy Moustafa , Aly Moustafa H. 
Published: August 2022

AbstractIn this paper, we analyze a combination based on a hybrid triple hop terrestrial free-space optical (FSO), a fiber optic cable (FOC), and an underwater optical wireless communication (UOWC) link for providing high-speed optical connectivity between onshore and submerge systems. UOWC, scattering, absorption, and turbulence severely degrade the reliability and transmission rate of the UOWC link. In our manuscript, a bend-insensitive intermediate FOC link and a spatial diversity (SD) are exploited to improve the error performance of UOWC links, which involves the deployment of multiple input single outputs (MISO). For this purpose, different transmission signaling schemes, such as pulse position modulation (PPM) with spatial modulation (SM) and on–off keying (OOK) with repetition coding (RC), are employed to evaluate the system performance in terms of average bit error rate (ABER). The behavior of the entire system is obtained by applying a decode-and-forward (DF), where we consider log-normal channels for FSO and UOWC. The path loss and turbulence are obtained using intensity modulation and direct detection schemes. To obtain performance results, Monte Carlo-based statistical simulation method is applied to validate the analytical ABER performance of the system. The achieved results reveal that MISO-OOK-RC has superior ABER performance as compared to MISO-PPM-SM in higher signal-to-noise ratio (SNR) conditions with different underwater turbulence strengths.
What is So Special About Contemporary CG Faces? Semiotics of MetaHumans
Authors: Giuliana Gianmarco Thierry 
Published: August 2022

AbstractThis paper analyses the features of the 2021 software for the creation of ultrarealistic digital characters “MetaHuman Creator” and reflects on the causes of such perceived effect of realism to understand if the faces produced with such software represent an actual novelty from an academic standpoint. Such realism is first of all defined as the result of semio-cognitive processes which trigger interpretative habits specifically related to faces. These habits are then related to the main properties of any realistic face: being face-looking, face-meaning and face-acting. These properties, in turn, are put in relation with our interactions with faces in terms of face detection, face recognition, face reading and face agency. Within this theoretical framework, we relate the characteristics of these artificial faces with such interpretative habits. To do so, we first of all make an examination of the technological features behind both the software and the digital faces it produces. This analysis highlights four main points of interest: the mathematical accuracy, the scanned database, the high level of details and the transformative capacities of these artificial faces. We then relate these characteristics with the cultural and cognitive aspects involved in recognizing and granting meaning to faces. This reveals how metahuman faces differs from previous artificial faces in terms of indexicality, intersubjectivity, informativity and irreducibility. But it also reveals some limits of such effect of reality in terms of intentionality and historical context. This examination consequently brings us to conclude that metahuman faces are qualitatively different from previous artificial faces and, in the light of their potentials and limits, to highlight four main lines of future research based on our findings.