bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fundamental-mode eigenfrequencies of neutral and charged twin neutron stars
Authors: Gonçalves Victor P. , Jiménez José C. , Lazzari Lucas 
Published: December 2022

AbstractWe investigate the effects of rapid and slow conversions on the fundamental-mode eigenfrequencies of hybrid neutron stars having highly discontinuous transitions between hadronic and quark matter, the so-called twin stars. We analyze some characteristic cases in the available parameter space of the equations of state for the hadronic and quark phases. Furthermore, we also consider the possibility that these stellar configurations are electrically charged. Our results indicate that for neutral configurations under rapid conversions the stability window coincides with the usual stability criterion, i.e.$$\partial M/\partial p_c > 0$$∂M/∂pc>0and that the two branches are disconnected. This discontinuity remains when electric charge is considered, but the usual criterion is not sufficient to determine the star’s stability. On the other hand, slow conversions connect initially disconnected branches and increase the stability window of the hybrid configurations. For both conversion speeds, the presence of electric charge diminishes the magnitude of the eigenfrequencies and its stability window.
Low Lymphocyte-to-Monocyte Ratio as a Possible Predictor of an Unfavourable Clinical Outcome in Patients with Acute Ischemic Stroke after Mechanical Thrombectomy
Authors: Pinčáková Katarína , Krastev Georgi , Haring Jozef , Mako Miroslav , Mikulášková Viktória , Bošák Vladimír 
Published: December 2022

Background. Although considerable progress has been made in the treatment of acute ischemic stroke (AIS), the clinical outcome of patients is still significantly influenced by the inflammatory response that follows stroke-induced brain injury. The aim of this study was to evaluate the potential use of complete blood count parameters, including indices and ratios, for predicting the clinical outcome in AIS patients undergoing mechanical thrombectomy (MT). Methods. This single-centre retrospective study is consisted of 179 patients. Patient data including demographic characteristics, risk factors, clinical data, laboratory parameters on admission, and clinical outcome were collected. Based on the clinical outcome assessed at 3 months after MT by the modified Rankin Scale (mRS), patients were divided into two groups: the favourable group (mRS 0–2) and unfavourable group (mRS 3–6). Stepwise multivariate logistic regression analysis was used to detect an independent predictor of the unfavourable clinical outcome. Results. An unfavourable clinical outcome was detected after 3 months in 101 patients (54.4%). Multivariate logistic regression analysis confirmed that the lymphocyte-to-monocyte ratio (LMR) was an independent predictor of unfavourable clinical outcome at 3 months (

odds

ratio
=
0.761

, 95% confidence interval 0.625–0.928, and

P
=
0.007

). The value of 3.27 was chosen to be the optimal cut-off value of LMR. This value could predict the unfavourable clinical outcome with a 74.0% sensitivity and a 54.4% specificity. Conclusion. The LMR at the time of hospital admission is a predictor of an unfavourable clinical outcome at 3 months in AIS patients after MT.
The Rise of Fascism in Brazil
Authors: Boito Armando 
Published: December 2022

Analysis of Brazil’s Bolsonaro administration, its most active social support base, and the political crisis that gave rise to it shows that, operating with a concept of fascism embedded in the Marxist tradition, it can be characterized as (neo)fascist. The political crisis of 2015–2018 that led to it involved a crisis of hegemony of the bloc in power, the crisis of party representation of the dominant classes, political activism by the state bureaucracy, the political defensiveness of the workers’ and lower-class movement, and the formation of a reactionary middle-class movement. The option for fascism was not without risks, as is reflected today by the demonstrations of dissatisfaction with its administration. Uma análise do governo Bolsonaro no Brasil, a sua base social a mais ativa e a crise política que lhe deve origem, mostra que, baseado num conceito de fascismo enquadrado na tradição marxista, este governo pode ser denominado como (neo)fascista. O governo (neo)fascista de Bolsonaro era decorrente de uma crise política nos anos 2015-2018 que implicou uma crise de hegemonia no bloco de poder, uma crise de representação partidária das classes dominantes, um ativismo político na burocrâcia estatal, uma atitude defensiva política do movimento dos trabalhadores e classes pobres e a formação de um movimento reacionário da classe média. A opçao fascista não é isento de riscos vis-à-vis a burguesia como se reflete hoje nas manifestações de insatisfação com a administração burguesa.
The use of natural language processing in palliative care research: A scoping review
Authors: Sarmet Max , Kabani Aamna , Coelho Luis , dos Reis Sara Seabra , Zeredo Jorge L , Mehta Ambereen K 
Published: December 2022

Background: Natural language processing has been increasingly used in palliative care research over the last 5 years for its versatility and accuracy. Aim: To evaluate and characterize natural language processing use in palliative care research, including the most commonly used natural language processing software and computational methods, data sources, trends in natural language processing use over time, and palliative care topics addressed. Design: A scoping review using the framework by Arksey and O’Malley and the updated recommendations proposed by Levac et al. was conducted. Sources: PubMed, Web of Science, Embase, Scopus, and IEEE Xplore databases were searched for palliative care studies that utilized natural language processing tools. Data on study characteristics and natural language processing instruments used were collected and relevant palliative care topics were identified. Results: 197 relevant references were identified. Of these, 82 were included after full-text review. Studies were published in 48 different journals from 2007 to 2022. The average sample size was 21,541 (median 435). Thirty-two different natural language processing software and 33 machine-learning methods were identified. Nine main sources for data processing and 15 main palliative care topics across the included studies were identified. The most frequent topic was mortality and prognosis prediction. We also identified a trend where natural language processing was frequently used in analyzing clinical serious illness conversations extracted from audio recordings. Conclusions: We found 82 papers on palliative care using natural language processing methods for a wide-range of topics and sources of data that could expand the use of this methodology. We encourage researchers to consider incorporating this cutting-edge research methodology in future studies to improve published palliative care data.
25-Gauge pars plana vitrectomy combined with air tamponade for primary rhegmatogenous retinal detachment
Authors: Shen Peiyang , Kong Xiangbin , Chen Guo , Jiang Jianhua , Yan Shigang , Lu Xiaohe , He Mingguang 
Published: December 2022

Objective This study was performed to evaluate the outcomes of 25-gauge (25-G) pars plana vitrectomy (PPV) with air tamponade for primary rhegmatogenous retinal detachment (RRD). Methods This retrospective consecutive case series included 126 eyes of 125 patients with primary RRD who underwent 25-G PPV with air tamponade. The patients were followed up for at least 6 months following surgery. The main outcome measures were the primary and final anatomical success rates and postoperative complications. Results The mean age of the 125 patients (80 men and 45 women) was 53.7 ± 10.0 years. The mean follow-up period was 8.3 ± 2.2 months (range, 6–18 months). Twenty-four eyes (19.0%) presented with high myopia, and 13 eyes (10.3%) were pseudophakic. Of the 126 eyes, 37 (29.4%) had inferior breaks, 2 (1.6%) had choroidal detachment, and 86 (68.3%) had macular detachment. The single- and final-operation success rates were 96.0% and 100%, respectively. Postoperative complications included macular hole formation in two eyes. During follow-up, secondary cataract surgery was performed in 27 (23.9%) of the 113 phakic eyes. Conclusion 25-G PPV with air tamponade is effective and safe in treating selected patients with primary RRD with a high anatomical success rate.
Narratives of Women with Infertility Who Use Indigenous Practices to Conceive, North West Province, South Africa
Authors: Baakeleng B. G. , Pienaar A. J. , Sithole P. M. , Mashego S. L. 
Published: December 2022

Infertility is a serious reproductive health challenge that has a far-reaching impact on women’s lives as they, inevitably, are the ones blamed for the failure to conceive. Despite availability of Western treatments to manage infertilit y, women frequently consult indigenous healthcare practitioners (IHCP) for healthcare, preferring these services to Western practice due to reasons such as accessibility and affordability. The study used a qualitative explorative, descriptive, and contextual design. Both purposive and snowballing technique were used to identify five women whom indigenous practitioners had assisted to conceive. Individual semi-structured interviews were conducted and data were analyzed using the Tesch method of data analysis. IHCPs are known experts in managing infertility, experiences of women on indigenous management of infertility and continuous holistic management of infertility among women.
Ingenol Mebutate Is Associated With Increased Reporting Odds for Squamous Cell Carcinoma in Actinic Keratosis Patients, a Pharmacovigilance Study of the FDA Adverse Event Reporting System (FAERS)
Authors: Jedlowski Patrick Michael 
Published: December 2022

Background Recently the production and marketing of ingenol mebutate in the European Union (EU) and Canada was halted due to a possible increased risk of squamous cell carcinoma (SCC) in patients with actinic keratosis (AK). Objective To investigate the relationship between SCC and topical AK medications including ingenol mebutate in the FDA Adverse Event Reporting System (FAERS). Methods Case/non-case analyses were performed in FAERS using data from 2012 to 2020 to examine the reporting odds ratio (ROR) signal for SCC for ingenol mebutate and all classes of topical AK medications under multiple conditions: i. comparison to all other drugs in FAERs, ii. comparison to other topical AK medications, iii. comparison to all other topical AK medications where only a single agent was implicated, iv. comparison of ingenol mebutate vs. imiquimod. Results A statistically significant ROR for SCC was found for ingenol mebutate under all conditions (i. 31.57 (25.45, 39.16), ii. 50.35 (32.21, 78.82), iii 61.09 (35.36, 105.56), iv. 2.53 (1.27, 5.05). A significant but substantially smaller signal was observed for imiquimod (i. 12.38 (6.42, 32.84), ii. 5.18 (2.61, 10.26), iii 5.42 (2.49, 11.78), but not for fluorouracil or diclofenac. When compared to imiquimod directly, ingenol mebutate had a statistically significant ROR for SCC (2.53 (1.27, 5.05). Conclusion Our findings support an association between SCC and ingenol mebutate. This association is maintained under controls to limit bias and falsely elevated signal including controlling for disease state and cases with multiple drug exposures and when compared to imiquimod as in Phase IV studies of ingenol mebutate.
Long-term Outcomes for Late-Phase Kienböck’s Tenoarthroplasty
Authors: Henry Mark , Lundy Forrest H. , Henry Giselle K. 
Published: December 2022

Background: In late Kienbӧck’s, the lunate is fully fragmented and nonreconstructible. Replacing the lunate with a pyrocarbon prosthesis preserves load distribution and avoids carpectomy or fusion, but leaves the wrist intrinsically unstable, requiring additional soft-tissue stabilization techniques. Methods: Five men and 7 women with a mean age of 43 (±15) years underwent prosthetic replacement of the lunate with dual bundle scaphoid-triquetrum tenodesis for carpal stabilization. The mean follow-up interval from initial surgery was 9.1 (±1.7) years. Outcomes were Disabilities of Arm, Shoulder, and Hand (DASH) score, revision or conversion surgery, and wrist range of motion. Results: The mean DASH score was 8.9 (±7.1). No patients reported any additional revision or conversion surgery. The mean wrist flexion was 60° (±14°); wrist extension was 45° (±21°). Conclusions: Clinical outcomes proved more favorable than anticipated, particularly the self-rated outcomes scores and the absence of any revision or conversion surgery.
The COVID conversations: A content analysis of Canadian pharmacy organizations’ communication of pharmacists’ roles and services during the COVID-19 pandemic
Authors: Safnuk Calli , Ackman Margaret L. , Schindel Theresa J. , Watson Kaitlyn E. 
Published: December 2022

Background: The COVID-19 pandemic presented a unique challenge for pharmacists as they navigated information scarcity on the frontlines while being identified as information experts. Alberta pharmacists looked to their professional organizations for direction regarding what their roles should be in a crisis. The objective of this study was to explore pharmacists’ roles and services and how they were communicated by pharmacy organizations during the first year of the COVID-19 pandemic. Methods: The study used a conventional content analysis method to explore the online communication of relevant pharmacy organizations for Alberta pharmacists. Five organization websites (National Association of Pharmacy Regulatory Authorities, Canadian Pharmacists Association [CPhA], Canadian Society of Hospital Pharmacists [CSHP], Alberta College of Pharmacy [ACP] and the Alberta Pharmacists’ Association [RxA]) were examined to identify and catalogue publicly accessible documents that communicated pharmacists’ roles and services during the first year of the pandemic for Alberta pharmacists. Results: A total of 92 documents were collected from CPhA (60), CSHP (2), ACP (26) and RxA (4). While most documents communicated information about pharmacists’ roles in public health, patient care and drug and personal protective equipment supply, more than one-third of the documents (32/92, 34.8%) required contextual information to interpret the communication. There was an observed shift in the communication after the first 6 months, becoming more direct in its messaging and context. Conclusion: These pharmacy organizations communicated information for pharmacists’ roles and services to provide direction and guidance in the ever-changing context of the COVID-19 pandemic for Alberta pharmacists. Their communication became clearer and more direct as the pandemic progressed, requiring less inference to understand the intended message.
Community pharmacist perceptions of drug–drug interactions
Authors: Dahri Karen , Araujo Louise , Chen Si , Bagri Harkaryn , Walia Keerti , Lau Louise , Legal Michael 
Published: December 2022

Background: Drug–drug interactions are preventable medication errors that can lead to serious negative outcomes for patients. Community pharmacists are uniquely positioned with their medication knowledge and role in prescription clinical assessment. However, workplace pressures and limitations related to computer systems can lead to drug–drug interactions being missed. There is a lack of information as to how community pharmacists assess drug interactions. Methods: A qualitative study using key informant interviews of community pharmacists was conducted. Pharmacists were questioned on their perceptions and views of drug interactions. Results: Eight community pharmacists participated. Four main themes were identified from the interviews: 1) pharmacist process of identifying drug interactions, 2) tools that help pharmacists assess and respond to drug interactions, 3) challenges in identifying and responding to clinically important drug interactions and 4) measures to avoid missing interactions. Discussion: Community pharmacists experience challenges around their lack of access to patient information, which limits their ability to properly assess drug–drug interactions. In addition, increasing workload pressures have affected their ability to ensure their patients receive optimal pharmaceutical care. There is also a disconnect between the community pharmacy computer systems’ alerts and their clinical relevancy to their specific patients. The overall burdens can lead to professional abstinence in the assessment of drug–drug interactions. Conclusion: Community pharmacists are in an ideal position to prevent patients from experiencing drug–drug interactions. However, to further enable them to fulfill this role, increased access to patients’ health records, decreased workload and better customization of computer alerts need to occur.
Simulating Prophylactic Fixation Methods for Osteoporotic Femoral Neck Fracture Prevention
Authors: Roytman Gregory R. , Ramji Alim F. , Beitler Brian , Yoo Brad , Leslie Michael P. , Baumgaertner Michael , Tommasini Steven M. , Wiznia Daniel H. 
Published: December 2022

Introduction Geriatric patients who suffer femoral neck fractures have high morbidity and mortality. Prophylactic fixation of the femoral neck is a potential avenue to reduce the incidence of femoral neck fractures. We studied 3 different implants traditionally used to stabilize the femoral neck: 6.5 mm cannulated screws (CANN), the femoral neck system (FNS) (Depuy Synthes), and the dynamic hip screw (DHS) (Depuy Synthes). Materials and Methods Five osteoporotic Sawbone femurs were used for each model and a control group. Two scenarios were investigated: single leg stance to measure construct stiffness and lateral impact to measure construct stiffness, energy to fracture, and qualitative examination of fracture patterns. Stiffness for each femur and energy to fracture for the lateral impact scenario were calculated and compared between groups using one-way ANOVA. Results DHS showed significantly higher stiffness than the other 2 implants and the control in single leg stance. In the lateral impact scenario, the DHS and CANN were significantly stiffer FNS and the control. Femurs implanted with CANN tended to fracture at the greater trochanter while FNS fractured in a transverse subtrochanteric pattern, and DHS fractured obliquely in the subtrochanteric region. Discussion FNS and DHS experienced fracture patterns less amenable to surgical correction. CANN and DHS proved better able to resist external forces in the lateral fall scenario. CANN also proved better able to resist external forces in the single leg stance scenario and experienced a more amenable fracture pattern in the lateral fall scenario. Conclusions FNS was less able to resist external forces compared with the other implants. This work informs the potential implications between the choice of implants that, although historically have not been used prophylactically, may be considered in the future for prophylactic stabilization of the femoral neck. Cadaveric study and clinical trials are recommended for further study.
Superficial and Deep Capillary Plexus Nonperfusion in Nonaccidental Injury on OCTA
Authors: Echegaray Jose J. , Iyer Prashanth , Acon Dhariana , Negron Catherin , El Hamichi Sophia , Berrocal Audina M. 
Published: December 2022

Purpose: To report OCTA findings in a case of nonaccidental injury (NAI). Methods: Retrospective review of a clinical case. Results: A 5-year-old White child with a history of NAI at age 1 year presented with reduced vision in the left eye resulting from a closed funnel retinal detachment. The right eye had optic nerve pallor, peripheral vascular attenuation, and leakage. Optical coherence tomography angiography (OCTA) showed significant parafoveal attenuation of the superficial vascular plexus, intermediate capillary plexus, and deep capillary plexus. This correlated with inner and middle retinal layer thinning temporal to the fovea and preservation of the ellipsoid zone. The peripapillary vascular plexus was preserved. Laser photocoagulation was performed to the nonperfused peripheral retina, and intravitreal bevacizumab was injected. Attenuation of the superficial, intermediate, and deep capillary plexuses might represent chronic ischemic retinal changes from traumatic injury to the vitreoretinal interface and inner retina in NAI. Conclusions: OCTA identified nonperfusion of the superficial and deep vascular plexuses as late sequelae of NAI. Traumatic injuries to the vitreoretinal interface in NAI might lead to inner retinal ischemia and atrophy with vascular attenuation present on OCTA.
Optical Coherence Tomography Angiography for Detecting Nonexudative Macular Neovascularization in Age-Related Macular Degeneration
Authors: Greenberg Jeremy R. , Kim Brian Y. , Brady Christopher J. , Millay Robert H. , Raut Robert 
Published: December 2022

Purpose: To compare the efficacy of optical coherence tomography angiography (OCTA) and indocyanine green angiography (ICGA) for detecting nonexudative macular neovascularization (MNV) in age-related macular degeneration (AMD). Methods: In this prospective study, patients with a new diagnosis of exudative AMD in 1 eye were imaged using OCTA, fluorescein angiography (FA), and ICGA in both eyes. The rates at which these imaging modalities detected nonexudative MNV in the nonexudative fellow eye were then compared. Results: This study comprised 41 eyes with a mean follow-up was 14 months. Nonexudative MNV was found in 3 eyes using OCTA and ICGA. No MNV exudation was detected on FA or structural OCT. One of 3 eyes with MNV progressed to exudative disease 6 months after the initial visit. During the follow-up, 5 of the 38 eyes without MNV developed exudation at 4 to 18 months. Conclusions: OCTA is similarly effective as ICGA at detecting nonexudative MNV patterns.