bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of Soft-Tissue Grafting in Peri-implantitis – An Original Research
Authors: Borah Rajshree , Cherukuri Sai Abhishiktha , Moturu Manasa , Baig Fawaz Abdul Hamid , Elanangai E. , Ahmad Faisal Noor , Tiwari Rahul V. C. 
Published: July 2022

Introduction:
With the increased application of the implants for the restoration of the lost teeth, the peri-implantitis cases are seen on a rise. Hence, we conducted a study retrospectively to evaluate, among the peri-implantitis cases, the success of the soft-tissue grafting.

Material and Methods:
We piloted a retrospective study among 50 subjects of both genders who underwent the soft-tissue grafting for the treatment of the peri-implantitis of a total of 69 implants. The clinical parameters noted were at the baseline and at various years of follow-ups. The data of the clinical parameters were noted, and the data thus noted were compared deliberating P < 0.05 as significant.

Results:
Thin soft-tissue biotype was noted among all the subjects, with the increased width of the keratinized mucosa. Significant lowering of the probing depth, bleeding on probing, and the mobility of the tissue were noted.

Conclusions:
We can conclude that soft-tissue grafting Is a benificial method for the peri-implantitis treatment.
Efficacy of Ozone to Eliminate Endopathogenic Microorganism in Rootcanal Biofilm
Authors: Pawar Madhura , Agwan Muhammed Atif Saleem , Toshniwal Nandalal G. , Biswas Krishna , Raina Rupshi , Pawar Swapnil 
Published: July 2022

Objective:
The researchers wanted to see whether ozonated water with ultrasonication and sodium hypochlorite can destroy Enterococcus faecalis bacteria in root canals.

Materials and Methods:
A total of 40 single-rooted human teeth were used. A total of 100 roots were harvested and mechanically prepared. The root canals were randomly divided into four classes (n = 10) after being infected with E. faecalis for 24 h. Each sample's MTT value was calculated.

Conclusions:
NaOCl and aqueous ozone provide antibacterial effects in in-vitro conditions in root canals.
In vitro Evaluation of Laser vs. Handpiece for Tooth Preparation
Authors: Vaddamanu Sunil K. , Vyas Rajesh , Kavita Kumari , Sushma R , Aboobacker Akhila S. , Dixit Arti , Kumar Amit 
Published: July 2022

Background:
The erbium-doped yttrium aluminium garnet (Er:YAG) laser has been revealed to effectively ablate dental hard tissues, and its utilisation to caries eradication and cavity preparation is envisaged. Nevertheless, only a limited research has been performed on the Er:YAG laser's capacity to treat caries.

Aim and Objectives:
The efficiency of caries elimination with an Er:YAG laser in vitro was equated to that of traditional mechanical therapy in this study.

Methodology:
The investigation made use of teeth that had suffered from root caries. The Er:YAG laser was used to treat half of each tooth, while the other half was either removed with a conventional bur or left untouched as a control. Each therapy was evaluated in terms of how long it took to remove cavities, histological examinations of decalcified serial sections, scanning electron microscopy (SEM) analyses and the density of the dentin.

Result:
A longer treatment time was required for the Er:YAG laser to completely eradicate carious dentin because of its precise irradiation strategy. However, the Er:YAG laser was effective in removing diseased and softening carious dentin with little heat injury to neighbouring intact dentin, much as the bur treatment. It was also shown that the Er:YAG laser treatment had a lower amount of vibration than other methods. The SEM study of the lased dentin surface revealed characteristic micro-irregularities.

Conclusion:
The Er:YAG laser system appears to be a potential novel technical option for caries therapy, based on our findings.
Detection of Human PapillomaVirus and its Association with Potentially Malignant Disorders and Oral Squamous Cell Carcinoma
Authors: Rathore Anushree , Tiwari Anushree , Nazim Maira , Gupta Anup Kumar , Gande Mounica , Krishnakumar Jyothi 
Published: July 2022

Aim:
This study was carried out with the objective of recognizing the involvement of human papillomavirus (HPV) in conditions of oral squamous cell carcinoma (OSCC) and oral potentially malignant conditions and lesions.

Materials and Methods:
OSCC samples from thirty patients were collected and thirty paraffin-embedded, oral premalignant specimens were collected. It was decided to use as a negative control samples gingiva from healthy individuals who had no prior history of oral proliferative leukoplakia or OSCC. The samples were then processed using a paraffin-embedded tissue block method. Deoxyribonucleic acid will be extracted from the paraffin-embedded tumor sample of sixty case subjects and tested for the presence of HPV DNA using polymerase chain reaction.

Results:
In study Group 1, 24 samples were taken from males and 6 from females. In study Group 2, 26 cases were males and 4 were females. In Group 1, 16 cases of moderately differentiated and 14 cases of well differentiated each were present. No case of poorly differentiated were found. There was statistically no significant difference present between male and female when Group 1 and Group 2 was considered. In study Group 1, 0 samples had positive HPV DNA detection, whereas 30 samples had negative HPV DNA detection. In study Group 2, 0 samples had positive HPV DNA detection, whereas 30 samples had negative HPV expression.

Conclusion:
According to our findings, certain incidences of OSCC may be linked to HPV, however, this was not the case for all of the cancers.
The integrated multidisciplinary European volcano infrastructure: from the conception to the implementation
Authors: Puglisi Giuseppe , Reitano Danilo , Spampinato Letizia , Vogfjörd Kristín S. , Barsotti Sara , Cacciola Lucia , Geyer Traver Adelina , Guðjónsson Davíð Steinar , Guehenneux Yannick , Komorowski Jean-Christophe , Labazuy Philippe , Lemarchand Arnaud , Nave Rosella , Saurel Jean-Marie , Bachelery Patrick 
Published: July 2022

Recent decades have highlighted the increasing need to connect and strengthen the volcanology community at European level. Indeed, research in the volcanology field is highly qualified in Europe and the volcano monitoring infrastructures have achieved valuable know-how, becoming the state-of-the-art in the world. However, the lack of common good practices in sciences and technologies, missing standards, as well as a significant fragmentation of the community requires coordination to move forward and guarantee a trans-national harmonisation. The European Plate Observing System (EPOS) represented the first opportunity to initiate this process of coordination by encouraging the creation of a European volcanological scientific infrastructure for data and service sharing. During the preparation and the design of EPOS, the volcanology community identified the objectives and the needs of the community building, the services to be provided and the work plan to implement the infrastructure. To achieve this aim, the contribution from three European projects FUTUREVOLC, MED-SUV and EUROVOLC was essential. This paper presents the main steps performed during the last years for building the community and implementing the infrastructure. This paper also describes the strategic choices and actions taken to realise the infrastructure such as the establishment of the Volcano Observation Thematic Core Service (TCS), whose structure and activity are described.
Integrating geological data in Europe to foster multidisciplinary research
Authors: Urvois Marc , Grellet Sylvain , Lorenz Henning , Haener Rainer , Loiselet Christelle , Harrison Matthew , Krivic Matija , Pedersen Christian Brogaard , Wiese Marianne B. , Baptie Amelia , Nayembil Martin , Trench James , Marsh Ivor , Cipolloni Carlo , D'Ambrogi Chiara , Congi Maria Pia 
Published: July 2022

The European Plate Observing System (EPOS, www.epos-eu.org) is a multidisciplinary pan-European research infrastructure for solid Earth science. It integrates a series of domain-specific service hubs (Thematic Core Service, TCS) such as the Geological Information and Modelling, which provides access to data, data products and services on European boreholes, geological maps, mineral occurrences, mines and 3D models. TCS GIM services are hosted by a group of European Geological Surveys and a couple of national research organizations. This paper presents novel data discovery and integration, facilitated using borehole logging information with on-demand web services to produce 3D geological structures. This domain interoperability across EPOS was created for the purpose of research, but it is also highly relevant for the response to societal grand challenges such as natural hazards and climate change. European and international interoperability implementation frameworks are well described and used (e.g., INSPIRE, ISO, OGC, and IUGS/CGI). It can be difficult for data providers to deploy web services that support the full semantic data definition (e.g., OGC Complex Feature) to expose several millions of geological entities through web-enabled data portals as required by pan-European projects. The TCS GIM group implemented and innovatively extended two standardized descriptions, i.e. GeoSciML-Lite and EarthResourceML-Lite, with an important reuse of content from Linked Data Registries. This approach was applied to design and implement the European Borehole Index and associated web services (View-WMS and Discovery-WFS), extended to 3D models, geological maps as well as mineral occurrences and mines. Results presented here apply the Linked Data approach ensuring optimal semantic description and enriching the data graphs, with complex descriptions and contents. In this way, it is now possible to traverse from one Borehole Index instance to linked richer information such as the borehole geological log, groundwater levels, rock sample description, analyses, etc. All this detailed information is served following international interoperability standards (Observations & Measurements, GroundWaterML 2.0, GeoSciML4, amongst others).
Needs analysis on the research capabilities of the Diocesan Secondary School teachers of Abra: basis for a capability enhancement program
Authors: Vasquez Reymond S. , Zales Jonathan P. , Atmosfera Rynheart P. 
Published: July 2022

This study revealed the needs in research of the diocesan secondary school teachers of Abra as a basis for a capability enhancement program. Questionnaire, documentary analysis, and unstructured interview were the instruments used in substantiating the needed data for the study. Forty – five (45) teachers were the respondents of the study. Descriptive – correlational methods of investigation were utilized in the study. Teachers of the selected schools are females, unmarried, and whose age is 28 years old and below. Most of them have already started their post graduate studies and were college graduates from private higher educational institutions. Further, majority of them did not yet experience to attend seminars in research. These teachers toughly need assistance in writing research proposals particularly in conceptualizing their framework. Moreover, they mostly need help in writing research conclusions. The teachers’ sex, civil status, age, highest educational attainment, type of school graduated from college, and attendance to seminars on research do not bring any significant effect to their level of needs in writing the research either in the proposal or in the full-blown research ready for journal publications. Therefore, there is really a need for the diocesan school teachers of Abra to be guided in the writing of research proposals and as well as in writing the full-blown research for journal publications. A research enhancement program is to be extended to them by agencies who provide technical support and assistance. Lastly, Administrators of these schools must send their faculty to attend research writing enhancement programs.
Effect of Risk Based Audit, Internal Control System and Organizational Commitment to Fraud Prevention With Ethical Considerations as Moderating Variables
Authors: Aviva Jihan 
Published: July 2022

The formulation in this study is how the influence of Risk Based Audit, Internal Control System, and Organizational Commitment to Fraud Prevention with Ethical Considerations as Moderating Variables. The aim is to determine the effect of Risk Based Audit, Internal Control System, and Organizational Commitment to Fraud Prevention with Ethical Considerations as Moderating Variables. This research uses associative research type. The place of research was carried out in BUMN in the city of Palembang. The data used is primary data. Data collection techniques are interviews and questionnaires. The sampling method used purposive sampling. The analytical method used is multiple linear regression analysis and moderate regression analysis. Together, Risk Based Audit, Internal Control System, and Organizational Commitment have an effect on Fraud Prevention. These results partially indicate that the Internal Control System has an effect on fraud prevention, Risk Based Audit and Organizational Commitment have no effect on Fraud Prevention. And in moderation Ethical Consideration is a Homologiser of Internal Control System Moderation on Fraud Prevention, Ethical Consideration is a Predictor of Risk Based Audit Moderation and Organizational Commitment to Fraud Prevention.
Keywords: Risk Based Audit, System, Commitment, Consideration, Prevention
Harta Menurut Pandangan Islam
Authors: Mukhlis Ibadurrohman 
Published: July 2022

Kebutuhan manusia atau kepuasan manusia dalam harta benda adalah situasi yang sama dengan kebutuhan hidup manusia untuk anak-anak dan juga kerabat. Dengan demikian, kebutuhan manusia akan harta merupakan kebutuhan yang mendasar, sebagaimana firman Allah swt dalam Surah al-Kahfi bait 46, yang berbunyi:
الْمَالُ وَالْبَنُونَ زِينَةُ الْحَيَاةِ الدُّنْيَا
A descriptive neuroimaging study of retinoblastoma in children: magnetic resonance imaging features
Authors: Orman Gunes , Huisman Thierry A.G.M. 
Published: July 2022

IntroductionRetinoblastoma (RB) is the most common intraocular malignancy of childhood. Magnetic resonance imaging (MRI) is essential for initial diagnosis, tumour extension, staging, and treatment planning of RB. Awareness of neuro­imaging findings and determining local extent are essential for early diagnosis and therapy guidance. The purpose of this study is to evaluate and to provide a detailed list of neuroimaging features of RB to improve the diagnostic work-up of children with RB.Material and methodsRetrospective review was performed among children with confirmed RB diagnosis. MRI features were identified to evaluate: 1) growth pattern; 2) intraocular extension; 3) extraocular extension; 4) central nervous system disease; 5) conventional MRI characteristics of the RB lesions; and 6) DWI and ADC characteristics. These features were compared between unilateral and bilateral RB lesions.ResultsTwenty-four children (male/female: 18/6) were included in this study. The mean age at the time of diagnosis was 14.7 (11.4) months. In total, 34 RB lesions (bilateral = 18) were evaluated for the study. The most common features on MRI were: 1) endophytic RB lesion (50%); 2) subretinal haemorrhage (38%); 3) scleral involvement (3%); 4) leptomeningeal disease (12%); 5) contrast enhancement (97%); and 6) restricted diffusion (88%). The mean ADC value was 0.64 (0.15) × 10-3 mm2/s. Choroidal invasion (p = 0.05) and scleral involvement (p = 0.04) were significantly higher for bilateral RB lesions.ConclusionsContrast enhancement and restricted diffusion are the most common neuroimaging features of RB. Choroidal invasion and scleral involvement are more frequently seen in bilateral disease.
Evaluation of the adipokine profile (adiponectin, resistin, adipsin, vaspin, and leptin) in patients with early rheumatoid arthritis and its correlation with disease activity
Authors: Chamorro-Melo Yany , Calixto Omar-Javier , Bello-Gualtero Juan , Bautista-Molano Wilson , Beltran-Ostos Adriana , Romero-Sánchez Consuelo 
Published: July 2022

IntroductionAdipokines may play a role in the early stages of rheumatoid arthritis. This study evaluated the performance of adipokines in a Colombian population with early rheumatoid arthritis and its relationship with disease activity.Material and methodsA cross-sectional study evaluated serum adipokine levels (adiponectin, resistin, adipsin, vaspin, and leptin) in patients with early rheumatoid arthritis (eRA), evaluating demographic and clinical variables, along with a control group matched by age and gender. A factorial analysis was performed using principal components analysis (PCA), and a Spearman correlation analysis was performed. Similarly, a cut-off point for serum levels is proposed based on the receiver operating characteristic (ROC) curve between eRA and controls and sensitivity analysis.ResultsFifty-one eRA subjects were included; there were 41 women. The body mass index (BMI) was 25.12 ±3.8. A statistically significant correlation was identified between adipsin, BMI, and RAPID3. Vaspin and leptin were correlated with BMI. Resistin levels were higher in patients with RAPID3 near remission (p = 0.041), and adiponectin, vaspin, and leptin levels were lower in patients with DAS28 ESR in remission (p = 0.033, p = 0.012, and p = 0.017, respectively). Principal components analysis in component 1 adipokines as adipsin and leptin with BMI and RAPID3 as disease activity index are grouped. Moreover, component 2 had a strong relation between ESR and CRP with an inverse correlation with cholesterol levels and vaspin. A cut-off point was established for each adipokine, thus identifying the best performance for leptin levels greater than 0.58 ng/ml with a sensitivity of 76.5% and specificity of 74.5%.ConclusionsAdipokine levels are relevant in eRA, especially with disease activity indexes. Resistin levels were higher in patients with an activity index near remission. Otherwise, adiponectin, vaspin, and leptin levels were lower in patients with low activity indexes. RAPID3 correlated with adipsin. It is complementary to the previously published analysis of adipokines.
PENGEMBANGAN FRAMEWORK MOBILE CLOUD COMPUTING DALAM MOBILE LEARNING SYSTEM UNTUK MENYEDIAKAN VIDEO LEARNING RESOURCES MATERIAL
Authors: Erlangga Erlangga , Wahyudin Wahyudin , Wihardi Yaya 
Published: July 2022

Dalam proses pembelajaran yang menggunakan Teknologi Informasi dan Komunikasi (TIK) sebagai sarana utamanya, ketersediaan bahan ajar multimedia sangat dibutuhkan, salah satunya bahan ajar dalam bentuk video. Sementara para pengajar umumnya memiliki keterbatasan dalam menciptakan bahan ajar dalam bentuk video, baik keterbatasan keterampilan maupun sumber daya. Model pemanfaatan bahan ajar seperti Reusable Learning Objects (RLOs), Open Educational Resources (OER), dan Massive Open Online Courses (MOOCs) telah diusulkan oleh para peneliti sebelumnya untuk membantu memperoleh bahan ajar, tetapi model tersebut umumnya menyediakan bahan ajar yang diperoleh dari lembaga-lembaga pendidikan. Tujuan dari penelitian ini adalah mengembangan framework mobile cloud computing dalam mobile learning system untuk menciptakan sebuah sistem yang dapat membantu pengajar dalam memperoleh bahan ajar video dari situs penyedia video seperti Youtube, Dailymotion, Showme, Vimeo dan lain-lain untuk pembelajaran tingkat dasar, menengah, atas dan perguruan tinggi. Metode yang digunakan ialah Mobile Development Life Cycle (MDLC). Hasil implementasi framework telah terbukti dapat menyediakan bahan ajar yang sesuai dengan kebutuhan. Para pengajar dari beberapa universitas, Hasil pengujian aplikasi cloud menunjukkan 79,5%, sedangkan hasil pengujian fungsional 75,65% dan pengujian expert 81,5% keseluruhan hasil pengujian menujukan bahwa hasil implementasi framework tersebut dapat menyediakan bahan ajar yang sesuai dengan kebutuhan siswa. Hasil dari penelitian ini menunjukkan bahwa aplikasi mobile learning berbasis cloud ini mampu memberikan manfaat kepada siswa dalam menyediakan video pembelajaran yang sesuai dengan kebutuhan siswa.
Cenegermin (Oxervate)
Authors: CADTH  
Published: July 2022

CADTH recommends that Oxervate be reimbursed by public drug plans for the treatment of moderate to severe neurotrophic keratitis (NK) in adult patients if certain conditions are met.
Oxervate should only be covered to treat patients who have never been treated with Oxervate before and have previously tried but failed conventional nonsurgical therapies.
Oxervate should only be reimbursed if prescribed by a cornea specialist experienced in the management of NK or by an ophthalmologist when comanaging the patient with a cornea specialist. Oxervate should not be prescribed along with preservative-containing topical antibiotics and/or antiviral eye drops. The cost of Oxervate should be reduced.
Lenvatinib (Lenvima) in Combination With Pembrolizumab (Keytruda)
Authors: CADTH  
Published: July 2022

CADTH recommends that Lenvima in combination with Keytruda be reimbursed by public drug plans for the treatment of adult patients with advanced or metastatic renal cell carcinoma (RCC) who have had no prior systemic therapy for metastatic disease if certain conditions are met.
Lenvima in combination with Keytruda should only be covered in patients aged 18 years and older with advanced (that cannot be cured with surgery or radiation) or metastatic (that has spread to other organs) RCC who have not received prior systemic therapy for advanced RCC.
Lenvima in combination with Keytruda should be reimbursed if prescribed under supervision in an outpatient oncology clinic or institution with expertise in delivering systemic therapy. Lenvima in combination with Keytruda should only be reimbursed when administered in combination and if cost is reduced.
Fostamatinib (Tavalisse)
Authors: CADTH  
Published: July 2022

CADTH reimbursement reviews are comprehensive assessments of the clinical effectiveness and cost-effectiveness, as well as patient and clinician perspectives, of a drug or drug class.
The assessments inform non-binding recommendations that help guide the reimbursement decisions of Canada's federal, provincial, and territorial governments, with the exception of Quebec.
This review assesses fostamatinib (Tavalisse), 100 mg or 150 mg tablet, oral.
Indication (Health Canada indication): for the treatment of thrombocytopenia in adult patients with chronic immune thrombocytopenia who have had an insufficient response to other treatments.
Analisis Kualitas Jaringan Fiber Optik Layanan Indihome Pada PT. Telkom di Wilayah Kota Ternate Tengah
Authors: Duwilaa Najamudin , Santosa Santosa , Hamza Sahriar 
Published: July 2022

Kebutuhan layanan komunikasi pada masa kini tidak hanya suara, melainkan juga data dan video. Maka diperlukan jaringan handal yang mampu memberikan performansi yang baik. Salah satu solusinya adalah jaringan fiber optik. Kantor wilayah PT. Telkom Kota Ternate adalah cabang dari PTTA yang menyediakan layanan telekomunikasi merekomendasikan jaringan akses Fiber To The Home dengan menggunakan teknologi Gigabit Passive Optical Network. Pada penelitian ini membahas tentang bagaimana kualitas jaringan fiber optik pada layanan IndiHome di wilayah Kota Ternate Tengah. Analisis yang digunakan melalui data parameter, diantaranya adalah Attenuation, RX Power, dan Attenaible Rate dari hasil pengukuran alat OTDR dan IBooster Speed yang digunakan oleh PTTA Kota Ternate. Karena adanya keterbatasan jaringan cooper (tembaga) yang dinilai belum cukup untuk mengakomodir permintaan kapasitas bandwidth dan bit-rate membuat pengembang layanan mulai untuk transisi ke serat optic. Maka topologi Fiber To The Home sebagai analisis karakteristik kabel serat optic dan simulasi tempat pemasangan jaringan layanan IndiHome.