bluuebunny/crossref_metadata_2025_split huggingface dataset:
Glass Fiber Post lengths and adhesive strategies to restore extensively damaged canines
Authors: Klüppel Neto Oscar João , Theodorovicz Kaye Varaschin , Mori Aline Akemi , Santin Gabriela Cristina , Lima Fernanda Ferruzzi , Pacheco Rafael Rocha , Sundfeld Daniel , Pini Núbia Inocêncya Pavesi 
Published: March 2022

The aim of this study was to evaluate different post lengths and adhesive strategies for restoring extensively damaged canines. Sixty human canines were randomly distributed into two groups (n=30), according to the resin cement used: self-adhesive or conventional. Each group was further distributed into 3 groups (n=10) based on the intracanal post lengths: 5, 7.5 and 10 mm. The radicular portion was endodontically filled, the cervical third was enlarged to simulate extensive damage and the coronal portion was reconstructed with composite resin. The samples were prepared with a simulated periodontal ligament and submitted to fatigue loading (160N – 1,200,000 cycles), followed by fracture resistance testing. The results were submitted to two-way ANOVA and Tukey tests (α=5%). The assessed glass fiber post lengths have not influenced on the fracture resistance (p>0.05). However, the performance of the conventional cements was better than the self-adhesive cements when the same post length was compared (p<0.05). Repairable fractures were prevalent (70-90%) in all groups tested. Conventional resin cement yielded higher fracture resistance than self-adhesive cement, regardless the post length adopted.
Estimativa da macroporosidade e microporosidade em função de sistemas de manejo e plantas de cobertura em Latossolo Vermelho cultivado com soja
Authors: Silva Jordhanna Marilia , Almeida Cinara Xavier de , Pena Luana Karolina , Jorge Ricardo Falqueto , Silva Leonardo Reis da , Duarte Iago Radamés Garcia 
Published: March 2022

Os sistemas de cultivos são práticas de manejo que têm por objetivo melhorar a produção agrícola. Diante disso, o cultivo convencional é caracterizado por utilizar técnicas tradicionais de preparo do solo, como aração e gradagem e no plantio direto há ocorrência mínima de revolvimento, com o solo sempre coberto por restos culturais. A quantificação da macroporosidade e microporosidade é de extrema importância para a determinação da qualidade física do solo, no entanto, é uma avaliação bastante trabalhosa. Nesse contexto, o objetivo do presente trabalho foi estimar estes atributos físicos a partir de equações propostas na literatura, em um Latossolo Vermelho argiloso em função de diferentes sistemas de manejo e de culturas em pré-safra à produção de soja, a partir de variáveis independentes como a textura e a densidade do solo. O experimento foi conduzido sob delineamento em blocos casualizados em faixas com esquema fatorial 2x6 e quatro repetições, pela combinação de dois sistemas de manejo (plantio direto e cultivo convencional) e cinco plantas de cobertura (crotalária, feijão-guandu, nabo forrageiro, milheto e lab-lab) e um pousio. Os dados foram submetidos à análise de variância e as médias comparadas pelo teste de Tukey, a 5% de significância. Concluiu-se que na camada 0-0,10 m os sistemas de preparo não apresentaram diferenças significativas para os atributos físicos avaliados. Já na camada 0,10-0,20 m o sistema de plantio direto apresentou menor valor de densidade do solo e maior macroporosidade em comparação ao plantio convencional. Dentre as plantas de cobertura, o nabo-forrageiro foi o que mais se destacou quanto a porosidade total e microporosidade do solo, em ambas as camadas avaliadas. Assim, a determinação dos atributos físicos do solo é de grande importância para o conhecimento do solo e aplicação de práticas adequadas de manejo.
Pelatihan Pengolahan Data Untuk Analisis Regresi Menggunakan Software Statistical Product And Service Solution (SPSS)
Authors: Juharsah Juharsah , Madi Riski Amalia , Hartini Hartini , Hamid Wahyuniati , Yusuf Yusuf , Hastuti Hastuti 
Published: March 2022

Kemampuan pengolahan data hasil penelitian sangat dibutuhkan untuk mempercepat penyelesaian penelitian dan pada akhirnya dapat mempercepat penyelesaian studi. Tujuan kegiatan pelatihan ini adalah untuk meningkatkan pengetahuan dan kemampuan peserta tentang; teori analisis regresi, pengolahan data menggunakan software SPSS, intepretasi output analisis regresi, dan meningkatkan kualitas penelitian. Kerangka pemecahan masalah kegiatan pelatihan ini dilakukan dalam beberapa tahapan, yaitu: mengidentifikasi peserta pelatihan, mengetahui pengetahuan dan kemampuan para peserta, menyampaikan materi pelatihan, dan evaluasi hasil kegiatan. Berdasarkan hasil evaluasi diketahui bahwa adanya peningkatan kemampuan peserta dalam pengolahan data untuk analisis regresi menggunakan software SPSS.
Solusi Pembelajaran Anak Usia Dini Pada Masa Pandemi Covid-19
Authors: Koedoes Yuni Aryani , Abubakar St. Rahmaniar , Hijriani Hijriani , Anshari Nur Muh Nadzirin 
Published: March 2022

Saat ini pandemi covid-19 melanda dunia dan Indonesia, banyak aspek yang berdampak khusunya di dunia pendidikan dan terkhusus lagi di pembelajaran anak usia dini, sekolah PAUD saat ini banyak terkendala dengan model dan sistem pembelajarn pada masa pandemic yang tidak memungkinkan pertemuan tatap muka langsung sehingga diperlukan solusi yang tepat untuk pembelajaran anak usia dini. Salah satu solusi adalah dengan melatih guru-guru PAUD dalam pembuatan dan pengembangan media pembelajaran interaktif berbasis multimedia mencakup asepek video, animasi, gambar dan audio serta pembuatan aplikasi games interaktif yang dikhususkan untuk pendidikan anak usia dini, penerapan multimedia ditujukan untuk memudahkan murid PAUD dalam memahami materi pelajaran karena memuat informasi gambar, video dan audio serta dengan muatan materi yang positif sesuai kebutuhan kurikulum PAUD. Metode yang digunakan adalah dengan metode pelatihan dan pendampingan, sehingga guru dapat melakukan pembuatan media pembelajaran serta akan dilanjutkan dengan pendampingan, untuk pelatihan menggunakan metode ADDIE Analysis, Design, Development, Implementation, and Evaluation), dimana model ini sangat baik digunakan dalam Instructional Design, khususnya dalam pembuatan media pembelajaran, Pada masa pandemi covid-19 ini kegiatan pengabdian masyarakat menyesuaikan dengan kondisi yaitu kami melaksanakan secara online dengan dikombinasikan pendampingan langsung dengan protokol kesehatan yang kegiatan, walau dilaksanakan secara online kegiatan dapat terlaksana dengan baik.Kata Kunci ; PAUD, Media, Pembelajaran, Multimedia, covid-19
Pelatihan Pembuatan Sabun Antiseptik Cair untuk Meminimalisasi Penularan Covid Melalui Gerakan Cuci Tangan
Authors: Kadidae La Ode , Kadir Laode Abdul , Nugrawaty Andi Laila 
Published: March 2022

Sambuli village lies along Nambo beach of Nambo district, City of Kendari Southeast Sulawesi province. This village is mainly occupied by fishermen and farmers. Nowadays, It is every citizen’s responsibility to remind each other about the danger of Covid-19 and the importance of how to limit the spread of the disease. Considering this issue, Institute of Research and Community Service Halu Oleo University arranged a team consisting of 3 academic-staff; two of them from Chemistry study program and one from Biotechnology study program, and 3 students. All the three students were from Chemistry Department. The aims of the team sent to the village were first to educate people of Sambuli about how to minimize the spread of Covid-19 disease and second is to train people of Sambuli to make liquid antiseptic soap. The soap would be used as an economical and practical substance for hand washing. The method used in this community service included public talking (mini seminar) and demonstration. During this community service, villagers got involved actively in discussion and participating actively during demonstration. They and their leaders were equally very enthusiastic and supportive. And in turn, the villagers with the assistance of students and academic staff of Halu Oleo University eventually managed to make liquid antiseptic soap by them shelves.
Edukasi Pencegahan Penyebaran Covid-19 Pada Masyarakat Desa Panggulawu Kabupaten Konawe Utara Di Era New Normal
Authors: Ismail Darwin , Kadir Laode A. , Wahab Wahab 
Published: March 2022

Panggulawu village lies along Panggulawu beach of Sawa, northern konawe district, Southeast Sulawesi province. This village is mainly occupied by civil servants (PNS), fishermen and farmers. Nowadays, It is every citizen’s responsibility to remind each other about the danger of Covid-19 and the importance of how to limit the spread of the disease. Considering this issue, Institute of Research and Community Service Halu Oleo University arranged a team consisting of 3 academic-staff; two of them from Chemistry study program and one from Mining study program, and 3 students. All the three students were from Chemistry Department. The aims of the team sent to the village is to educate people of Panggulawu about how to minimize the spread of Covid-19 disease. The method used in this community service included is public talking (mini seminar). During this community service, villagers got involved actively in discussion and participating actively during demonstration. They and their leaders were equally very enthusiastic and supportive.
Pendampingan Teknis Aplikasi Teknologi Mesin Tetas di Kelurahan Labibia Kecamatan Mandonga Kota Kendari
Authors: Saili Takdir , Nafiu La Ode , Arsad Sani La Ode , Libriani Restu , Abadi Musram , Sulfitrana Andini , Surahmanto Surahmanto , Dewi S Rachmita 
Published: March 2022

Peternak ayam kampung di Kelurahan Labibia Kecamatan Mandonga Kota Kendari belum ada sentuhan teknologi tepatguna dalam meningkatkan produktivitasnya. Peternak masih menggunakan sistem pengeraman alami, sehingga peningkatan produksi ayam menjadi rendah, disisi lainnya adalah produksi telur ayam kampung hanya mencapai 40 butir pertahun yang disebabkan induk ayam masih membutuhkan waktu untuk mengasuh anaknya setelah telur ditetaskan secara alami. Oleh karena itu, perlu dilakukan upaya penerapan teknologi melalui penetasan secara buatan (artificial incubation) dengan mesin tetas yang dapat memberikan manfaat dan memungkinkan tersedianya bibit ayam dalam jumlah yang banyak. Disisi lain penggunaan mesin tetas dapat menekan biaya pembelian DOC, sehingga dapat meningkatkan pendapatan bagi peternak ayam kampung. Pelaksanaan pengabdian Program Bina Desa Fakultas Peternakan UHO diharapkan dapat memberikan solusi atas permasalahan yang dihadapi oleh peternak, yaitu dengan memperkenalkan inovasi teknlogi budidaya ayam kampung melalui pendampingan teknis aplikasi teknologi mesin tetas. Program Bina Desa Fakultas Peternakan UHO dilaksanakan di Kelurahan Labibia Kecamatan Mandonga Kota Kendari. Pelaksanaan program dilakukan dalam bentuk penyuluhan dan bimbingan teknis. Materi penyululuhan meliputi penguatan kelembagaan, konsep dasar inovasi teknologi mesin tetas sederhana dan ekonomis, metode pengoleksian telur tetas dan metode pengoperasian alat mesin tetas. Sedangkan materi pada bimbingan teknis meliputi tehnik pembuatan mesin tetas, tehnik pengoleksian telur tetas dan tehnik pengoperasian alat mesin tetas. Berdasarkan kegiatan yang telah dilaksanakan, hasil yang telah dicapai pada Program Bina Desa di Kelurahan Labibia Kecamatan Mandonga Kota Kendari dengan penerapan inovasi teknologi sederhana melalui bimbingan teknis pembuatan mesin tetas dapat meningkatakan pengetahuan dan keterampilan peternak dalam pembuatan mesin tetas pada kelompok ternak, serta dapat menekan biaya pembelian DOC sehingga dapat meningkatkan pendapatan peternak
Fatty Acid Supplementation During in vitro Embryo Production Determines Cryosurvival Characteristics of Bovine Blastocysts
Authors: Aardema H. , Bertijn I. , van Tol HTA. , Rijneveld A. , Vernooij JCM. , Gadella B. M. , Vos PLAM 
Published: March 2022

In vitro production (IVP) embryos have a reduced quality and poor cryotolerance in comparison to in vivo embryos. This study investigated whether free fatty acid (FFA) conditions, fatty acid free (FAF)- synthetic oviduct fluid (SOF) without or with 25 μM of saturated stearic (C18:0) or unsaturated oleic (C18:1) acid during the first 5 IVP days, relate to quality and cryosurvival of day 8 blastocysts. Apart from the blastocyst scores, both 1) number and size of lipid droplets of fresh blastocysts and 2) total number and apoptotic and necrotic cells, before and after freezing-thawing, were scored by confocal microscopy. Blastocyst rates were significantly lower in the FAF SOF condition in comparison to other groups. Interestingly, blastocysts originating from the C18:1 group, with a significantly higher lipid content, and blastocysts from the FAF SOF group demonstrated a high cryosurvival rate (70.1 and 67.4%, respectively) comparable with in vivo blastocysts (68%), in contrast to the poor cryosurvival of C18:0 exposed embryos (17.6%). In all freeze-thawed embryos the average amount of apoptotic and necrotic cells increased albeit that the C18:0 condition rates were higher (43.2%) when compared to C18:1 (26.0%) and FAF SOF conditions (26.5%). The current data show that FFA administered during early embryonic development significantly affect the cryotolerance of blastocysts.
Differential Effects of Reperfusion on Cardiac Mitochondrial Subpopulations in a Preclinical Porcine Model of Acute Myocardial Infarction
Authors: Chandra Shekar Kadambari , Yannopoulos Demetris , Kosmopoulos Marinos , Riess Matthias L. 
Published: March 2022

Acute myocardial infarction (AMI) leads to localized cardiac ischemia and can be fatal if untreated. Despite being treatable, the threat of ischemia-reperfusion (IR) injury remains high. Mitochondria are central to both propagation and mitigation of IR injury, and cardiac mitochondria are categorized into two major subtypes—subsarcolemmal and interfibrillar mitochondria (SSM and IFM, respectively). We hypothesized that, in our pre-clinical porcine model of AMI, SSM and IFM are differentially affected by reperfusion. AMI was induced in female pigs by balloon occlusion of the left anterior descending artery for 45 min, followed by 4 h of reperfusion. At the end of reperfusion, animals were euthanized. Cardiac SSM and IFM from the affected ischemic area and a nearby non-ischemic area were isolated to compare mitochondrial function using substrates targeting mitochondrial electron transport chain complexes I and II. Despite detecting overall significant differences in mitochondrial function including yield, mitochondrial S3 and S4 respirations, and calcium retention, consistent individual functional differences in the two mitochondrial subpopulations were not observed, both between the two mitochondrial subtypes, as well as between the ischemic and non-ischemic tissue. Nonetheless, this study describes the mitochondrial subtype response within the initial few hours of reperfusion in a clinically relevant model of AMI, which provides valuable information needed to develop novel mitochondrially targeted therapies for AMI.
Tungsten Promoted Ni/Al2O3 as a Noble-Metal-Free Catalyst for the Conversion of 5-Hydroxymethylfurfural to 1-Hydroxy-2,5-Hexanedione
Authors: Duan Ying , Wang Rui , Liu Qihang , Qin Xuya , Li Zuhuan 
Published: March 2022

The conversion of 5-hydroxymethylfurfural (HMF) to 1-hydroxy-2,5-hexanedione (HHD) represented a typical route for high-value utilization of biomass. However, this reaction was often catalyzed by the noble metal catalyst. In this manuscript, W promoted Ni/Al2O3 was prepared as a noble-metal-free catalyst for this transformation. The catalysts were characterized by XRD, XPS, NH3-TPD, TEM, and EDS-mapping to study the influence of the introduction of W. There was an interaction between Ni and W, and strong acid sites were introduced by the addition of W. The W promoted Ni/Al2O3 showed good selectivity to HHD when used as a catalyst for the hydrogenation of HMF in water. The influences of the content of W, temperature, H2 pressure, reaction time, and acetic acid (AcOH) were studied. NiWOx/Al2O3-0.5 (mole ratio of W:Ni = 0.5) was found to be the most suitable catalyst. The high selectivity to HHD was ascribed to the acid sites introduced by W. This was proved by the fact that the selectivity to HHD was increased a lot when AcOH was added just using Ni/Al2O3 as catalysts. 59% yield of HHD was achieved on NiWOx/Al2O3-0.5 at 393 K, 4 MPa H2 reacting for 6 h, which was comparable to the noble metal catalyst, showing the potential application in the production of HHD from HMF.
Determination of Agrin and Related Proteins Levels as a Function of Age in Human Hearts
Authors: Skeffington Katie L. , Jones Ffion P. , Suleiman M. Saadeh , Caputo Massimo , Brancaccio Andrea , Bigotti Maria Giulia 
Published: March 2022

Background:Mature cardiomyocytes are unable to proliferate, preventing the injured adult heart from repairing itself. Studies in rodents have suggested that the extracellular matrix protein agrin promotes cardiomyocyte proliferation in the developing heart and that agrin expression is downregulated shortly after birth, resulting in the cessation of proliferation. Agrin based therapies have proven successful at inducing repair in animal models of cardiac injury, however whether similar pathways exist in the human heart is unknown.MethodsRight ventricular (RV) biopsies were collected from 40 patients undergoing surgery for congenital heart disease and the expression of agrin and associated proteins was investigated.ResultsAgrin transcripts were found in all samples and their levels were significantly negatively correlated to age (p = 0.026), as were laminin transcripts (p = 0.023), whereas no such correlation was found for the other proteins analyzed. No significant correlations for any of the proteins were found when grouping patients by their gender or pathology. Immunohistochemistry and western blots to detect and localize agrin and the other proteins under analysis in RV tissue, confirmed their presence in patients of all ages.ConclusionsWe show that agrin is progressively downregulated with age in human RV tissue but not as dramatically as has been demonstrated in mice; highlighting both similarities and differences to findings in rodents. Our results lay the groundwork for future studies exploring the potential of agrin-based therapies in the repair of damaged human hearts.
A Risk Score to Diagnose Cardiac Involvement and Provide Prognosis Information in Patients at Risk of Cardiac Light-Chain Amyloidosis
Authors: Wu Yan , Pu Cailing , Zhu Wenchao , He Chengbin , Fei Jingle , Hu Hongjie 
Published: March 2022

BackgroundCardiac light-chain amyloidosis (AL CA) portends poor prognosis. Contrast cardiac magnetic resonance (CMR) with late gadolinium enhancement (LGE) imaging is an important tool in recognizing AL CA. But contraindications to contrast CMR would significantly restrict its clinical application value. Our study aims to construct a convenient risk score to help identify cardiac involvement in patients at risk of AL CA. Moreover, we also investigate whether this risk score could provide prognosis information.Materials and MethodsSixty-three patients at risk of AL CA were retrospectively included in our study. Basic clinical characters, lab results, 12-lead electrocardiogram data, and cardiac magnetic resonance image data were collected. AL CA was diagnosed according to typical CA LGE pattern. Logistic analysis was used to figure out predictive parameters of AL CA and their β coefficients, further constructing the risk score. Receiver operating characteristics (ROC) curve was used to find the cut-off point best distinguishing AL CA+ from AL CA–patients. Bootstrapping was used for internal validation. All patients were divided into high-risk and low-risk group according to the diagnostic cut-off point, and followed up for survival information. Kaplan-Meier plots and log-rank test were performed to analyze if this score had prognostic value.ResultsThe risk score finally consisted of 4 parameters: pericardial effusion (PE) (1 point), low electrocardiographic QRS voltages (LQRSV) (1 point), CMR-derived impaired global radial strain (GRS) (&lt;15.14%) (1 point) and increased left ventricular maximum wall thickness (LVMWT) (&gt;13 mm) (2 points). Total score ranged from 0 to 5 points. A cut-off point of 1.5 showed highest accuracy in diagnosing AL CA with an AUC of 0.961 (95% CI: 0.924–0.997, sensitivity: 90.6%, specificity: 83.9%). Kaplan-Meier plots and log-rank test showed that the high-risk group had significantly poor overall survival rates.ConclusionIn patients at risk of AL CA, a risk score incorporating the presence of PE, LQRSV, and CMR-derived impaired GRS and increased LVMWT is predictive of a diagnosis of AL CA by LGE criteria. This risk score may be helpful especially when contrast CMR is not available or contraindicated, and further studies should be considered to validate this score.
Impact of Valve Size on Paravalvular Leak and Valve Hemodynamics in Patients With Borderline Size Aortic Valve Annulus
Authors: Talmor-Barkan Yeela , Kornowski Ran , Bar Noam , Ben-Shoshan Jeremy , Vaknin-Assa Hanna , Hamdan Ashraf , Kruchin Boris , Barbash Israel M. , Danenberg Haim , Perlman Gidon Y. , Konigstein Maayan , Finkelstein Ariel , Steinvil Arie , Merdler Ilan , Segev Amit , Barsheshet Alon , Codner Pablo 
Published: March 2022

BackgroundTranscatheter heart valve (THV) selection for transcatheter aortic valve implantation (TAVI) is crucial to achieve procedural success. Borderline aortic annulus size (BAAS), which allows a choice between two consecutive valve sizes, is a common challenge during device selection. In the present study, we evaluated TAVI outcomes in patients with BAAS according to THV size selection.MethodsWe performed a retrospective study including patients with severe aortic stenosis (AS) and BAAS, measured by multi-detector computed tomography (MDCT), undergoing TAVI with self-expandable (SE) or balloon-expandable (BE) THV from the Israeli multi-center TAVI registry. The aim was to evaluate outcomes of TAVI, mainly paravalvular leak (PVL) and valve hemodynamics, in patients with BAAS (based on MDCT) according to THV sizing selection in between 2 valve sizes. In addition, to investigate the benefit of shifting between different THV types (BE and SE) to avoid valve size selection in BAAS.ResultsOut of 2,352 patients with MDCT measurements, 598 patients with BAAS as defined for at least one THV type were included in the study. In BAAS patients treated with SE-THV, larger THV selection was associated with lower rate of PVL, compared to smaller THV (45.3 vs. 64.5%; pv = 0.0038). Regarding BE-THV, larger valve selection was associated with lower post-procedural transvalvular gradients compared to smaller THV (mean gradient: 9.9 ± 3.7 vs. 12.5 ± 7.2 mmHg; p = 0.019). Of note, rates of mortality, left bundle branch block, permanent pacemaker implantation, stroke, annular rupture, and/or coronary occlusion did not differ between groups.ConclusionBAAS is common among patients undergoing TAVI. Selection of a larger THV in these patients is associated with lower rates of PVL and optimized THV hemodynamics with no effect on procedural complications. Additionally, shift from borderline THV to non-borderline THV modified both THV hemodynamics and post-dilatation rates.