bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reproducible method for assessing the effects of blue light using in vitro human skin tissues
Authors: Kala Rishabh , Heiberger Nicole , Mallin Heather , Wheeler Stephanie , Langerveld Anna 
Published: November 2022

AbstractIntroductionHigh‐intensity visible light (HEV), also referred to as blue light, has a wavelength of 400–500 nm and accounts for approximately one‐third of the visible light. Blue light is also emitted from electronic devices and artificial indoor lighting. Studies have shown that exposure of human skin cells to light emitted from electronic devices, even as short as 1 h, can cause an increase in reactive oxygen species (ROS), apoptosis and necrosis. Despite comprising a significant portion of the light spectrum, the effects of HEV light have not been studied as extensively. This is in part due to a lack of suitable in vitro testing methods. This work was conducted in order to develop a reproducible testing method for assessing the effects of blue light on the skin.MethodsTesting was performed using a full thickness, 3D in vitro skin tissue model. Different exposure protocols were tested to (1) determine the biological effects of blue light on the skin and (2) to identify an appropriate exposure for routine testing of cosmetic materials that may protect the skin from blue light damage. Gene expression and protein biomarkers were measured using qPCR, ELISA and immunohistochemical (IHC) methods.ResultsOur work demonstrates that daily exposure to blue light produced dose‐and‐time‐dependent changes in biomarkers associated with skin damage. Exposure to blue light for 6 h for 5 consecutive days (total intensity of 30 J/cm2) increased the expression of genes that regulate inflammation and oxidative stress pathways and decreased the expression of genes that maintain skin barrier and tissue integrity. Exposure to blue light significantly increased protein biomarkers associated with ageing, inflammation and tissue damage. IHC staining confirmed changes in collagen, filaggrin and NQO1 protein expression. Treatment with ascorbic acid inhibited the effects of blue light, demonstrating a role in protection from blue light.ConclusionOur results showed that consistent blue light exposure produced skin damage via alterations in biological pathways that are associated with skin ageing. This work provides a new, reproducible in vitro testing method for assessing the effects of blue light on human skin using gene expression, protein ELISA and IHC staining.
Effect of Mo and W interlayers on microstructure and mechanical properties of Si3N4–nickel‐base superalloy joints
Authors: Singh Mrityunjay , Fernandez Julian Martinez , Asthana Rajiv , Ramirez‐Rico Joaquin , Valera‐Feria Francisco Manuel 
Published: November 2022

AbstractSi3N4/nickel‐base superalloy (Inconel‐625) and Si3N4/Si3N4 joints with refractory metal (W and Mo) interlayers were vacuum brazed using a Ti‐active braze Cu‐ABA (92.75Cu–3Si–2Al–2.25Ti) at 1317 K for 30 min with the following interlayered arrangements: Si3N4/Mo/W/Inconel and Si3N4/Mo/W/Si3N4. The joints exhibited Ti segregation at the Si3N4/Cu‐ABA interface, elemental interdiffusion across the joint interfaces, and sound metallurgical bonding. Knoop microhardness profiles revealed hardness gradients across the joints that mimicked the interlayered arrangement. The compressive shear strength of Si3N4/Si3N4 joints both with and without W and Mo layers was ∼142 MPa but the strength of Si3N4/Inconel joints increased from ∼9 MPa for directly bonded joints without interlayers to 53.5 MPa for joints with Mo and W interlayers.
A gene chip study suggests that miR‐17‐3p is associated with diabetic foot ulcers
Authors: Sun Xin‐juan , Chen Jin‐an , Wang Lei , Li Gai , Wang Ai‐ping 
Published: November 2022

AbstractBackground of the Study Diabetic foot ulcers (DFUs) are severe effect of diabetes. This research aimed to discover the role of micro‐ribonucleic acid (miRNA) in treating DFUs involved in maggot debridement therapy (MDT) via a miRNA chip study. A miRNA chip approach was adopted. Patients with diabetes (type 1 or 2) who had at least one‐foot ulcer (current or previous) were enrolled in the study. The alterations of miRNA expressions in the granulation tissue during treatment with MDT were measured. Following MDT, the increased expression of miR17‐92 was verified in vivo. The miR‐17‐3p expression increased, and Flk‐1 (vascular endothelial growth factor) expression was significantly reduced in patients with DFUs who received MDT (P < 0.01). Results from human umbilical vein endothelial cells that excrete or secrete showed consistency with in vitro findings (P < 0.001, P < 0.05). The overexpression of miR‐17‐3p demonstrated inhibitory activity on tube formation (P < 0.05). When DFUs were treated with MDT, it revealed that miR‐17‐3p had a negative regulatory effect on Flk‐1.
Compulsory Vaccination and Nozickian Rights
Authors: Clarke Simon 
Published: November 2022

ABSTRACTThis article examines compulsory vaccination from the perspective of Nozick's theory of rights. It argues that the unvaccinated are a threat, even if unintended, to the rights of others. The reasons Nozick provides for when such threats may be forcibly prevented, such as the identifiability of the rights violator, general fear of the risky activity, probability of harm, and the general benefits of the activity, are examined, and it is argued that those reasons weigh in favour of prohibition of the threat and hence in favour of compulsory vaccination. It is also argued that anyone opposed to compulsory vaccination on Nozickian grounds faces a dilemma: if they reject compulsory vaccination, they also risk rejecting the very foundations of the legitimacy of the state.
Focal pancreatic ductal change induced by 10‐Fr S‐type plastic stent in chronic pancreatitis
Authors: Takuma Kensuke , Okano Naoki , Ito Ken , Ujita Wataru , Iwata Shuntaro , Mizutani Saori , Nakagawa Hiroki , Watanabe Koji , Yamada Yuto , Kimura Yusuke , Yoshimoto Kensuke , Iwasaki Susumu , Hara Seiichi , Kishimoto Yui , Igarashi Yoshinori , Matsuda Takahisa , Amemiya Kazuki 
Published: November 2022

AbstractBackground and AimStent‐induced ductal change (SIDC) is a complication of endoscopic pancreatic stenting (EPS) in patients with chronic pancreatitis (CP). However, the evaluation of SIDC associated with S‐type pancreatic plastic stent (PS) and large‐caliber PS, such as 10 Fr, is limited. This study aimed to analyze the SIDC of the main pancreatic duct (MPD) associated with 10‐Fr S‐type PS in patients with CP.MethodsBetween January 2008 and December 2021, 132 patients with CP in whom a 10‐Fr S‐type PS had been installed by EPS were retrospectively reviewed. The SIDC incidence rate was examined, and the clinical features of patients with and without SIDC were investigated, including the outcomes for detected SIDC.ResultsStent‐induced ductal change during EPS was confirmed in 41 patients (31.1%) of 132 patients at a site coincident with the PS tip or distal flap in the MPD. All patients were asymptomatic during the development of SIDC. Morphological changes in the MPD were detected as elevated (75.6%) or bearing stricture changes (24.4%). A total of 90.2% of SIDC developed after the first 10‐Fr PS installation. No significant differences were noted between the patients with and without SIDC. The outcomes of continued PS installment for SIDC showed persistence and secondary change.ConclusionsStent‐induced ductal change‐associated 10‐Fr PS installation was performed in just under one‐third of the patients, indicating a substantial incidence rate and a possible development of SIDC from early stages onwards. More emphasis should be placed on SIDC as the complication.
Use of long‐term services and supports among dual‐eligible beneficiaries with Alzheimer's disease and related dementias
Authors: Kim Hyunjee , Senders Angela , Simeon Erika , Juarez Cesar , Huang Sean , Dodge Hiroko , McConnell K. John 
Published: November 2022

AbstractBackgroundTo respect people's preference for aging in place and control costs, many state Medicaid programs have enacted policies to expand home and community‐based services as an alternative to nursing facility care. However, little is known about the use of Medicaid long‐term services and supports (LTSS) at a national level, particularly among dual‐eligible beneficiaries with Alzheimer's disease and related dementias (ADRD).MethodsUsing Medicare and Medicaid claims of 30 states from 2016, we focused on dual‐eligible beneficiaries 65 years or older with ADRD and described their use of any form of LTSS and sub‐types of LTSS (home‐based, community‐based, and nursing facility services) across states.ResultsWe found that 80.5% of dual‐eligible beneficiaries with ADRD received some form of Medicaid LTSS in 2016. The most common LTSS setting was nursing facility (46.7%), followed by home (31.5%) and community (12.2%). There was sizeable state variation in the percentage of dual‐eligible beneficiaries with ADRD who used any form of LTSS (ranging from 61% in Maine to 96% in Montana). The type of LTSS used also varied widely across states. For example, home‐based service use ranged from 9% in Maine, Arizona, and South Dakota to 62% in Oregon. Nursing facility services were the most common type of LTSS in most states. However, home‐based service use exceeded nursing facility use in Oregon, Alaska, and California.ConclusionsOur findings suggest substantially different use of LTSS across states among dual‐eligible beneficiaries with ADRD. Given the importance of LTSS for this population and their families, a deeper understanding of state LTSS policies and other factors that contribute to wide state variation in LTSS use will be necessary to improve access to LTSS across states.
Rice FLOURY ENDOSPERM22, encoding a pentatricopeptide repeat protein, is involved in both mitochondrial RNA splicing and editing and is crucial for endosperm development
Authors: Yang Hang , Wang Yunlong , Tian Yunlu , Teng Xuan , Lv Zehui , Lei Jie , Duan Erchao , Dong Hui , Yang Xue , Zhang Yuanyan , Sun Yinglun , Chen Xiaoli , Bao Xiuhao , Chen Rongbo , Gu Chuanwei , Zhang Yipeng , Jiang Xiaokang , Ma Wenyu , Zhang Pengcheng , Ji Yi , Zhang Yu , Wang Yihua , Wan Jianmin 
Published: November 2022

ABSTRACTMost of the reported P‐type pentatricopeptide repeat (PPR) proteins play roles in organelle RNA stabilization and splicing. However, P‐type PPRs involved in both RNA splicing and editing have rarely been reported, and their underlying mechanism remains largely unknown. Here, we report a rice floury endosperm22 (flo22) mutant with delayed amyloplast development in endosperm cells. Map‐based cloning and complementation tests demonstrated that FLO22 encodes a mitochondrion‐localized P‐type PPR protein. Mutation of FLO22 resulting in defective trans‐splicing of mitochondrial nad1 intron 1 and perhaps causing instability of mature transcripts affected assembly and activity of complex Ⅰ, and mitochondrial morphology and function. RNA‐seq analysis showed that expression levels of many genes involved in starch and sucrose metabolism were significantly down‐regulated in the flo22 mutant compared with the wild type, whereas genes related to oxidative phosphorylation and the tricarboxylic acid cycle were significantly up‐regulated. In addition to involvement in splicing as a P‐type PPR protein, we found that FLO22 interacted with DYW3, a DYW‐type PPR protein, and they may function synergistically in mitochondrial RNA editing. The present work indicated that FLO22 plays an important role in endosperm development and plant growth by participating in nad1 maturation and multi‐site editing of mitochondrial messager RNA.
Association of socio‐economic status and ethnicity with mortality and morbidity of premature infants admitted to neonatal intensive care in South Auckland, New Zealand
Authors: Pacella Marisa J , Meyer Michael P 
Published: November 2022

AimSocio‐economic status (SES) and ethnicity have been associated with worse maternal and fetal outcomes. Counties Manukau is a region of New Zealand which has a high portion of the population living in areas of low SES and has a higher population of ethnic minorities (Pacific Islander, Asian and Maaori). To determine whether SES and ethnicity are associated with worse mortality and morbidity in preterm infants in Counties Manukau Hospital, New Zealand.MethodsThis retrospective cohort study compared the infants of mothers who live in the most deprived neighbourhoods to the infants of mothers who live in the least deprived neighbourhoods. Infants born between 2000 and 2019 were included if <30 weeks gestation or <1500 g and born in hospital. Primary outcome was combined mortality/morbidity.ResultsUnivariate analysis showed demographic differences between the SES and ethnic groups, for example maternal age and maternal smoking. Using logistic regression, SES was not associated with worse neonatal outcomes for the most deprived SES (n = 624) compared to least deprived SES (n = 164). Ethnicity (n = 1326) was not associated with worse neonatal outcomes. Gestational age and maternal smoking were associated with neonatal mortality/morbidity; gestational age and antenatal steroids were associated with neonatal mortality. It was notable that the proportion of the study population in the less deprived groups used for the comparisons was relatively low.ConclusionsFor preterm, in‐hospital births in Counties Manukau over a 20‐year period, neonatal outcomes were the same regardless of SES or ethnicity.
Sleep disorders among rural Veterans: Relative prevalence, comorbidities, and comparisons with urban Veterans
Authors: Folmer Robert L. , Smith Connor J. , Boudreau Eilis A. , Totten Annette M. , Chilakamarri Priyanka , Atwood Charles W. , Sarmiento Kathleen F. 
Published: November 2022

AbstractPurposeTo describe and compare demographic characteristics and comorbidities of rural and urban Veterans diagnosed with sleep disorders, and to evaluate whether rurality is a disparity for sleep care among Veterans.MethodsNumbers of Veterans with sleep disorders and comorbid conditions were determined using the Department of Veterans Affairs (VA's) Corporate Data Warehouse, a database that contains detailed clinical information for all Veterans who receive VA health care. Comparisons between urban and rural Veterans were conducted for fiscal years (FY) 2010‐2021.FindingsThe prevalence of diagnosed sleep disorders was similar among rural and urban Veterans from FY2010 to 2021 and increased for both groups during this time period. The prevalence of chronic pulmonary disease, congestive heart failure, and diabetes mellitus was higher for rural Veterans with sleep disorders compared to their urban counterparts. From 2012 to 2021, the percentage of rural Veterans who received sleep care at VA facilities was lower than the percentage of urban Veterans who received VA sleep care during the same time span.ConclusionsAlthough rural Veterans exhibited a higher prevalence of 3 comorbid conditions associated with sleep disorders, the prevalence of sleep disorder diagnoses was similar between rural and urban Veterans. Therefore, it is possible that sleep disorders are underdiagnosed among rural Veterans. The fact that rural Veterans received VA sleep care at a lower rate compared to urban Veterans indicates that rurality is a disparity in access to care in this population. VA is addressing this disparity through a variety of programs, including telehealth initiatives.
Phosphorylation status of CPK28 affects its ubiquitination and protein stability
Authors: Liu Xiaotong , Zhou Yuanyuan , Chen Kexin , Xiao Zejun , Liang Xuelian , Lu Dongping 
Published: November 2022

Summary

Plant innate immunity is tightly regulated. The Arabidopsis thaliana CALCIUM‐DEPENDENT PROTEIN KINASE28 (CPK28) functions as a negative immune regulator. We recently demonstrate that CPK28 undergoes ubiquitination that is mediated by two ubiquitin ligases, ARABIDOPSIS TÓXICOS EN LEVADURA31 (ATL31) and ATL6, which results in its proteasomal degradation. CPK28 undergoes both intermolecular autophosphorylation and BIK1‐mediated phosphorylation. However, whether the phosphorylation status of CPK28 dictates its ubiquitination and degradation is unknown yet.

We used immune response analysis, transient degradation system, ubiquitination assays, co‐immunoprecipitation, and other biochemical and genetic approaches to investigate the effect of the phosphorylation status of CPK28 on its degradation mediated by ATL31/6.

We found the mutation of Ser318 (a site of both intermolecular autophosphorylation and BIK1‐mediated phosphorylation) or a BIK1 phosphorylation site on CPK28 leads to its compromised association with ATL31 and reduced ubiquitination by ATL31. Moreover, we confirm the previous findings that two CPK28s can interact with each other, which likely promotes the intermolecular autophosphorylation. We also show that the phosphorylation status of CPK28 in turn affects its intermolecular association.

We demonstrate that the phosphorylation status of CPK28 affects its degradation mediated by ATL31. Our findings reveal a link between phosphorylation of CPK28 and its ubiquitination and degradation.
Ichthyosis, petechiae, and arthrogryposis in a neonate
Authors: Haller Courtney N. , Paladichuk Hana , Ziats Catherine A. , Buchanan Catherine A. , Diaz Lucia Z. 
Published: November 2022

AbstractGaucher disease is a rare lysosomal storage disorder caused by a deficiency in glucocerebrosidase. This enzyme deficiency leads to the accumulation of toxic metabolites in various organs. Multiple subtypes of this disease have been described; however, the perinatal‐lethal form is extremely rare and challenging to diagnose. We present a case of a newborn girl with ichthyosis, petechiae, and arthrogryposis, later found to be homozygous for a pathogenic variant of the glucocerebrosidase gene. This case highlights the potential role of dermatologists in the recognition of this rare disease.
Recruitment in personnel psychology and beyond: Where we've been working, and where we might work next
Authors: Dineen Brian R. , Yu Kang Yang Trevor , Stevenson‐Street Julia 
Published: November 2022

AbstractEffective recruitment of talent remains extremely critical. As part of Personnel Psychology's 75‐year anniversary celebration, we review the state of recruitment research, emphasizing the journal's extensive contributions to this literature. Specifically, we review contributions and opportunities in terms of the recruitment outcomes that have been studied, theoretical progress that has occurred, and methodologies that have been employed to inform scholarship and practice. Throughout, we particularly highlight trends that have occurred over the years in the pages of Personnel Psychology. We conclude with several implications for practice and directions for ongoing recruitment research.
Pyrroloquinolines, a New Platform for Developing Organic Photosensitizers: When Synthetic Methodology Meets Photophysics†
Authors: Amara Zacharias 
Published: November 2022

AbstractNew molecular architectures with triplet sensitization properties can have a big impact on photochemistry and photobiology. In their recent work, de Bonfils et al. have tackled this challenge in a very systematic way using a powerful synthetic strategy. This consists of an elegant yet practical organocatalyzed cyclization/oxidation rearrangement sequence which they now apply to the synthesis of pyrroloquinolines, a new scaffold for photosensitizers. However, beyond this new class of compounds, the strategy has potential to produce a myriad of compact organic chromophores with promising photoinduced intersystem crossing properties. The study therefore provides interesting clues to serve the rational design of biocompatible molecular photosensitizers but also raises puzzling questions on the intriguing excited state reactivity of these molecular architectures.
The contributions of potassium phosphite and hormonal pathways to the control of Phytophthora infestans in tomato cv. Micro‐Tom
Authors: Dallagnol Leandro J. , de Oliveira Tatiane S. , Simmi Francine Z. , Farias Raphael S. , Peres Lazaro E. P. , Pascholati Sérgio F. , Camargo Luis E. A. 
Published: November 2022

AbstractPhytophthora infestans causes the destructive late blight disease in tomato and its control is achieved mainly by fungicides. Resistance inducers such as potassium phosphite (KPhi) represent an environmentally friendly alternative for control. The effect of KPhi on disease severity and on the activity of antioxidant enzymes was investigated in wild‐type (WT) Micro‐Tom plants and mutant/transgenic genotypes were used to determine the hormonal pathways required for resistance. KPhi presented a systemic action and reduced disease severity up to 86% depending on the mode (foliar spray or irrigation) and time of application (3 or 7 days before inoculation). The compound reduced the concentration of phenolics and altered the activity of antioxidant enzymes, notably of catalase, whose activity was reduced even before pathogen inoculation, indicating a physiological effect. In addition, KPhi was toxic to the pathogen in an in vitro assay. Disease severity on plants that overproduce ethylene, are insensitive to brassinosteroid (BR) or do not accumulate salicylic acid was higher than in the WT, revealing that these hormonal pathways are involved in the reaction to P. infestans. The results indicate a possible mode of action of KPhi through the early accumulation of H2O2 and interplay with the salicylic acid pathway. This is the first report on the involvement of BR against this pathogen and the results point to a positive effect on resistance. This study extends the understanding of the role of KPhi as a disease control agent, confirming it as a good option to be used in the management of late blight.
Before blaming the tooth extraction for the TTS, consider alternative triggers
Authors: Finsterer Josef , Stollberger Claudia 
Published: November 2022

AbstractTakotsubo syndrome (TTS), also known as stress cardiomyopathy; is characterized by a clinical presentation similar to that of myocardial infarction but with normal coronary arteries. Four subtypes of TTS are distinguished, the classical type (apical form), the basal subtype, the reverse subtype, and the global subtype. TTS is triggered by physical stress in one‐third of cases, by psychological stress in another third, and in the remaining third of cases the trigger remains unknown. Whether stress during tooth root extraction can trigger TTS is unknown but some rare reports suggest that such a dental procedure can trigger TTS. However, before tooth root extraction can be held responsible for triggering TTS, various different causes must be ruled out.