bluuebunny/crossref_metadata_2025_split huggingface dataset:
An overview of factors affecting the quality of beef meatballs: Processing and preservation
Authors: Meng Xiangren , Wu Danxuan , Zhang Zhaoli , Wang Hengpeng , Wu Peng , Xu Zhicheng , Gao Ziwu , Mintah Benjamin Kumah , Dabbour Mokhtar 
Published: April 2022

AbstractBeef meatball (BM) is a traditional delicious snack with rich nutrition and unique flavor, making it a preferred choice for most consumers. However, the quality of BM is easily affected by many factors, such as the processing, storage, and preservation, which limit the competitive positioning with respect to its market. Therefore, it is essential to pay attention to each step during the processing of BMs. Based on previous studies, this systematic review focuses on the effect of key processing factors (including raw materials and ingredients, beating, cooking methods, storage, and preservation) on the quality of BMs. Additionally, this study assessed the effect of each process factor on the physicochemical, sensory, nutritional, and safety attributes of BMs. Finally, the existing review will be beneficial in examining/describing the factors impacting the quality of BMs during processing, which would provide theoretical reference and scientific basis for the standardization and industrialization of BMs.
Intraday liquidity in soybean complex futures markets
Authors: de Boer Thomas A. P. , Gardebroek Cornelis , Pennings Joost M. E. , Trujillo‐Barrera Andres 
Published: April 2022

AbstractWe examine persistence and cross‐market liquidity spillovers in the Chicago Mercantile Exchange soybean complex futures markets. A multidimensional liquidity measure is derived from the limit‐order‐book, and a Vector Heterogeneous Autoregressive model estimates high‐resoluted liquidity from 30 s to one trading day. We find traders' order placement influenced by the liquidity of related markets. Liquidity persistence and positive liquidity spillovers mainly occur within 30 s, whereas spillovers for longer horizons are mostly negative. Findings are important for hedgers that hedge the crush and traders who wish to capitalize on the short‐term deviation of price relationships.
All eyes on the price: An assessment of the willingness‐to‐pay for eyeglasses in rural Burkina Faso
Authors: Grimm Michael , Hartwig Renate 
Published: April 2022

AbstractVision impairment is the most common disability worldwide and it is untreated in large parts of the developing world. We assess the willingness‐to‐pay (WTP) for eyeglasses among adults in a resource‐poor rural setting. We elicit the WTP using the Becker‐DeGroot‐Marschak (BDM) method. We combine this approach with a layaway scheme and a video intervention to probe to what extent liquidity constraints and information influence the WTP. Our results show that the average WTP is close to the cost of production for corrective glasses. Nevertheless, we find evidence for information constraints. Our video intervention raises the WTP for corrective glasses by 16 percent. We do not find evidence of screening effects, that is after 6 months, use is unrelated to the initial WTP.
Continuous multidimensional assessment system of medical residents in teaching hospitals
Authors: Yousefi Mehdi , Ebrahimi Zahra , Fazaeli Somayeh , Mashhadi Leila 
Published: April 2022

AbstractBackground and aimsEvaluation of learners is considered as one of the most important principles in education, especially in the clinical fields. Continuous assessment can be used to provide appropriate feedback to students about their strengths and weaknesses. In this regard, this study is aimed to design a system of continuous assessment of medical residents (SCMARs).MethodsThis study was performed using a combination of qualitative methods, including focus group discussion, expert panel, and Delphi technique. The study population consisted of all the stakeholders involved in the evaluation process of medical residents in Imam Reza Hospital Complex (IRHC) in Iran. This study was conducted in three phases, including identification of subthemes and indicators, production of a primary framework for the SCMAR, and agreement on the subthemes of the SCMAR. The nominal group technique was used for generating priority information. Data analysis was performed during the agreement review stage with the Excel software version 2016.ResultsThe finalized SCMAR consisted of 10 main themes and 38 subthemes. The themes included objectives, evaluators, areas, and indicators of evaluation, evaluation periods, evaluation requirements, data collection, data sources, point assignment and data analysis methods, reporting, and feedback dissemination methods. Five areas of evaluation and 11 indicators of evaluation were proposed.ConclusionA comprehensive assessment system that continuously evaluates the performance of Medical Residents can be used as a stimulus to improve the quality of educational processes. The present study was aimed to address this need by designing a framework for such a system.
Predictors of response to ambulatory pharmacist‐led diabetes care
Authors: Palka Samuel J. , Koeller Jim M. , Davidson DeWayne , Zeidan Amina R. , Reveles Kelly R. 
Published: April 2022

AbstractPurposeAmbulatory care pharmacists have been shown to significantly improve health outcomes of patients with type 2 diabetes mellitus (T2DM); however, it is unclear which patients are most likely to benefit from these services. The primary objective of this study was to describe clinical response to pharmacist‐led diabetes care and identify baseline and interventional variables that are independently predictive of clinical response.MethodsThis was a retrospective cohort study of adult patients with T2DM referred for ambulatory care pharmacist diabetes management at one of two health systems in San Antonio, Texas from January 1, 2015 to December 31, 2018. Data were collected at baseline and during 6 months of follow‐up. Clinical response was defined as hemoglobin A1C (A1C) reduction from baseline ≥1% or meeting the documented A1C goal. Predictors of clinical response were identified using multivariable logistic regression, including 25 patient and clinical intervention covariates.ResultsA total of 180 patients were included. Patients were predominantly female (63%) and obese (58%) with a T2DM duration ≥10 years (67%). The median (interquartile range) change in A1C from baseline for responders and non‐responders was −2.2% (−3.7 to 1.3) and 0.4% (−0.4 to 1.05) (P < .001), respectively. Significant predictors of response included baseline A1C (odds ratio [OR] 1.41; 95% confidence interval [CI] 1.08‐1.85), number of completed visits with the pharmacist (OR 1.65; 95% CI 1.03‐2.64), and medication frequency reduction (OR 10.7; 95% CI 1.04‐109.9). Number of primary care provider visits was a negative predictor of response (OR 0.69; 95% CI 0.49‐0.96).ConclusionPharmacist‐led diabetes management was associated with reduced A1C levels in patients with T2DM. Higher patient baseline A1C, more visits with the pharmacist, and medication frequency reduction were predictive of clinical response and should be considered in future patient referral and management protocols.
Guidelines for therapeutic interchange—2022
Authors:   American College of Clinical Pharmacy, Welty Timothy E. , Hilaire Michelle L. , Frantzen Leah M. , Achey Thomas S. , Minze Molly G. , Japs Kelsey L. , Elliott Amber N. , Brasher Cynthia A. , May Dianne W. , Mosley Scott A. , Johnson Corinne G. , Grimm Derek L. , Huffman Sara 
Published: April 2022

AbstractThe American College of Clinical Pharmacy (ACCP) Board of Regents charged the 2020 to 2021 Publications Committee to review and revise the 2004 ACCP guideline statement on therapeutic interchange. The committee reviewed previous guidelines and relevant published literature. After development of new guidelines, the committee and Board of Regents voted in support of the updated guideline. The ACCP reaffirms its support of therapeutic interchange. Additional recommendations for appropriate implementation and practice of therapeutic interchange are provided. Therapeutic interchange is an important tool in optimizing patient care, improving access to care, and reducing the cost of medications.
Osteochondral regeneration in rabbit using xenograft decellularized ECM in combination with different biological products; platelet‐rich fibrin, amniotic membrane extract, and mesenchymal stromal cells
Authors: Rastegar Adib Fatemeh , Bagheri Fatemeh , Sharifi Ali Mohammad 
Published: April 2022

AbstractThis study aimed to investigate the regenerative effect of decellularized osteochondral ECM xenograft in combination with various biological products in an osteochondral (OC) defect. OC tissue from the sheep femur were obtained and decellularized. The decellularized ECM (dECM) was combined with either platelet‐rich fibrin (PRF), amniotic membrane extract (AME), or rabbit bone marrow‐derived mesenchymal stromal cells (rBMSCs). The hybrid dECM‐biological products were then utilized for the treatment of rabbit OC critical size defects. The regenerative potential of different groups was compared using; MRI, macroscopic assessment, histopathology, and histomorphometry. All characterizations analysis verified successful decellularization. Three months post‐surgery, macroscopic findings indicated that dECM was better compared to controls. Also, dECM in combination with AME, PRF, and rBMSCs showed enhanced OC regeneration compared to only dECM (AME: +100%, PRF: +61%, rBMSCs: +28%). In particular, the dECM+AME group results in the best integration of new cartilage into surrounding cartilage tissue. The histomorphometric evaluations demonstrated enhancement in new cartilage formation and bone tissue (86.5 ± 5.9% and 90 ± 7.7%, respectively) for the dECM+AME group compared to other groups. Furthermore, histological results for the dECM+AME elucidated a mature hyaline cartilage tissue that covered the new and symmetrically formed subchondral bone, exhibiting a significantly higher regenerative effect compared to all other treated groups. This finding was also confirmed with MRI images. The current study revealed that in addition to the benefits of dECM alone, its combination with AME indicated to have a superior regenerative effect on OC regeneration. Overall, dECM+AME may be considered a suitable construct for treating knee OC injuries.
Assessment of extracellular vesicle isolation methods from human stool supernatant
Authors: Northrop‐Albrecht Emmalee J. , Taylor William R. , Huang Bing Q. , Kisiel John B. , Lucien Fabrice 
Published: April 2022

AbstractExtracellular vesicles (EVs) are of growing interest due to their potential diagnostic, disease surveillance, and therapeutic applications. While several studies have evaluated EV isolation methods in various biofluids, there are few if any data on these techniques when applied to stool. The latter is an ideal biospecimen for studying EVs and colorectal cancer (CRC) because the release of tumour markers by luminal exfoliation into stool occurs earlier than vascular invasion. Since EV release is a conserved mechanism, bacteria in stool contribute to the overall EV population. In this study, we assessed five EV separation methods (ultracentrifugation [UC], precipitation [EQ‐O, EQ‐TC], size exclusion chromatography [SEC], and ultrafiltration [UF]) for total recovery, reproducibility, purity, RNA composition, and protein expression in stool supernatant. CD63, TSG101, and ompA proteins were present in EV fractions from all methods except UC. Human (18s) and bacterial (16s) rRNA was detected in stool EV preparations. Enzymatic treatment prior to extraction is necessary to avoid non‐vesicular RNA contamination. Ultrafiltration had the highest recovery, RNA, and protein yield. After assessing purity further, SEC was the isolation method of choice. These findings serve as the groundwork for future studies that use high throughput omics technologies to investigate the potential of stool‐derived EVs as a source for novel biomarkers for early CRC detection.
Secondary hemophagocytic lymphohistiocytosis associated with Rocky Mountain spotted fever in a toddler: A case report
Authors: Hosahalli Vasanna Smitha , Lim Peter Paul C. , Khan Tanya Saeeda , Dalal Jignesh 
Published: April 2022

AbstractA three‐year‐old boy presented with fever, maculopapular rash involving palms and soles, and hyponatremia two weeks following a tick bite. Empiric doxycycline that he was on was discontinued following negative initial rickettsial serology based on the non‐endemicity of Rocky Mountain spotted fever (RMSF) in Northeast Ohio. He demonstrated high inflammatory markers and met the criteria for hemophagocytic lymphohistiocytosis (HLH). With a working diagnosis of macrophage activation syndrome secondary to presumed systemic‐onset juvenile idiopathic arthritis (soJIA), he received HLH‐directed therapy. Rising antibody titers in convalescent sera established the diagnosis of RMSF. The patient recovered completely with HLH directed therapy and re‐institution of doxycycline. This is the first pediatric case report of Rickettsia rickettsii induced HLH demonstrating a favorable outcome despite modified therapy.
Incidence of active tuberculosis among people living with HIV receiving long‐term antiretroviral therapy in high TB/HIV burden settings in Thailand: implication for tuberculosis preventive therapy
Authors: Suwanpimolkul Gompol , Gatechompol Sivaporn , Kawkitinarong Kamon , Ueaphongsukkit Thornthun , Sophonphan Jiratchaya , Siriyakorn Nirada , Jirajariyavej Supunnee , Khusuwan Suwimon , Panarat Palakorn , Wannalerdsakun Surat , Saetiew Natcha , Chayangsu Sunee , Wiwatrojanagul Sirichai , Noopetch Preudtipong , Danpornprasert Praniti , Mekviwattanawong Sripetcharat , Fujitnirun Chris , Lertpiriyasuwat Cheewanan , Han Win Min , Kerr Stephen J. , Ruxrungtham Kiat , Avihingsanon Anchalee ,   and the HIV‐TB study team
Published: April 2022

AbstractIntroductionAmong high tuberculosis (TB) and HIV burden countries in Asia, tuberculosis preventive therapy (TPT) in people living with HIV (PLWH) has been underutilized despite its proven benefits independent of antiretroviral therapy (ART). Therefore, we determined the incidence of active TB and mortality among 9179 adult PLWH who attended and received ART from 15 tertiary care hospitals across Thailand.MethodsA retrospective study was conducted in 2018 using follow‐up data from 1999 to 2018. The primary endpoint was incident TB disease after ART initiation. Factors associated with TB incidence were analysed using competing risk regression. The Kaplan–Meier method was used to estimate mortality after ART initiation.ResultsDuring a median of 5.1 years of ART (IQR 2.2–9.5 years), 442 (4.8%) PLWH developed TB (TB/HIV), giving an overall incidence of 750 (95% CI 683–823) per 100,000 persons‐year of follow up (PYFU). In multivariate analysis, lower CD4 at ART initiation (≤100 cells/mm3, adjusted sub‐distribution hazard ratio [aSHR]: 2.08, 95% CI, 1.47–2.92; 101–200 cells/mm3, aSHR: 2.21, 95% CI, 1.54–3.16; 201–350 cells/mm3, aSHR: 1.59, 95% CI, 1.11–2.28 vs. >350 cells/mm3), male sex (aSHR: 1.40, 95% CI, 1.11–1.78), lower body weight (<50 kg, aSHR: 1.52, 95% CI, 1.17–1.95) and prior TB event (aSHR: 3.50, 95% CI, 2.72–4.52) were associated with TB incidence. PLWH with HIV RNA ≥50 copies/ml had 5–9 times higher risk of active TB disease higher than those with HIV RNA <50 copies/ml at the same CD4 level. The risk for developing TB was remarkably high during the initial period of ART (175,511 per 100,000 PYFU at<3 months) and was comparable to the general population after 10 years of ART (151 per 100,000 PYFU). TB/HIV had higher mortality (10% vs. 5%) and poorer HIV treatment outcomes: HIV RNA <50 copies/ml (63.8% vs. 82.8%), CD4 cells count (317 vs. 508 cells/mm3) at the most recent visit.ConclusionsIn this high TB burden country, TB incidence was remarkably high during the first few years after ART initiation and thereafter decreased significantly. Rapid ART initiation and appropriate TPT can be potential key interventions to tackle the TB epidemic and reduce mortality among PLWH in TB/HIV high burden settings.
Cross-reactive cellular, but not humoral, immunity is detected between OC43 and SARS-CoV-2 NPs in people not infected with SARS-CoV-2: Possible role of cTFH cells
Authors: García-Jiménez Álvaro Fernando , Cáceres-Martell Yaiza , Fernández-Soto Daniel , Martínez Fleta Pedro , Casasnovas José M , Sánchez-Madrid Francisco , Frade José Miguel Rodríguez , Valés-Gómez Mar , Reyburn Hugh T 
Published: April 2022

AbstractMultiple questions about SARS-CoV-2 humoral and cellular immunity remain unanswered. One key question is whether preexisting memory T or B cells, specific for related coronaviruses in SARS-CoV-2-unexposed individuals, can recognize and suppress COVID-19, but this issue remains unclear. Here, we demonstrate that antibody responses to SARS-CoV-2 antigens are restricted to serum samples from COVID-19 convalescent individuals. In contrast, cross-reactive T cell proliferation and IFN-γ production responses were detected in PBMCs of around 30% of donor samples collected prepandemic, although we found that these prepandemic T cell responses only elicited weak cTFH activation upon stimulation with either HCoV-OC43 or SARS-CoV-2 NP protein. Overall, these observations confirm that T cell cross-reactive with SARS-CoV-2 antigens are present in unexposed people, but suggest that the T cell response to HCoV-OC43 could be deficient in some important aspects, like TFH expansion, that might compromise the generation of cross-reactive TFH cells and antibodies. Understanding these differences in cellular responses may be of critical importance to advance in our knowledge of immunity against SARS-CoV-2.
An exploration of teens’ perspectives of poverty through photovoice: Implications for counselors
Authors: Sackett Corrine R. , Rapa Luke J. , De Alba Rachel E. 
Published: April 2022

AbstractResearchers explored teens’ perspectives of poverty in their environments through a qualitative participatory action research method called photovoice. Six themes emerged from the data reflecting teens’ experiences with poverty: (1) materialistic world and discrepancies, (2) ability to care for self and others, (3) racism and discrimination, (4) vandalism and abandonment, (5) community responses, both helpful and not helpful, and (6) ignoring issues and lack of awareness. The authors address implications of these findings for counselors.
Identification of potential plasma markers for hepatitis B virus‐related chronic hepatitis and liver fibrosis/cirrhosis
Authors: Zhao Dandan , Yu Songhao , Guo Peilin , Zhang Xiaoxiao , Tang Yuhui , Dong Chen , Zhao Suxian , Li Lu , Al‐Dhamin Zaid , Ai Rong , Xue Ningning , Dong Shiming , Nan Yuemin 
Published: April 2022

AbstractThe aim of this study was to identify potential plasma biomarkers for hepatitis B virus (HBV)‐related liver diseases. High‐throughput transcriptome sequencing analysis was performed on five patients with chronic hepatitis B (CHB), five patients with HBV‐associated liver fibrosis/liver cirrhosis (LF/LC), and four healthy participants. By short time‐series expression miner and functional analysis, aquaporin 1 (AQP1), dystroglycan 1 (DAG1), and hemoglobin subunit beta (HBB) were identified as potential biomarkers. Immunohistochemical analysis revealed that the expression levels of AQP1, DAG1, and HBB were upregulated in the three groups. Subsequent enzyme‐linked immunosorbent assay tests on the training cohort (n = 150) indicated that the plasma levels of AQP1 and DAG1 were highest in LF/LC patients, followed by those in CHB patients, and the lowest in healthy controls. APAD model, a diagnostic panel incorporating age, platelet, AQP1, and DAG1 levels, exhibited the strongest stratification ability to distinguish LF/LC patients from CHB patients, and to differentiate CHB patients from healthy controls. Furthermore, the diagnostic accuracies of the biomarkers and APAD model were verified in an independent cohort consisting of 230 participants. In conclusion, both AQP1 and DAG1 have good diagnostic values and APAD model greatly enhances the diagnostic accuracy for HBV‐related hepatic diseases.
Percutaneously introduced wireless intramuscular near‐infrared spectroscopy device detects muscle oxygenation changes in porcine model of lower extremity compartment syndrome
Authors: Westman Amanda M. , Guo Hexia , Xu Yameng , Bai Wubin , Liu Yiming , Ouyang Wei , Moritz William , Jacobson Lauren , Weng Yang , Zang Hao , Wu Changsheng , Hu Ziying , Li Shuo , Lu Di , Arafa Hany M. , MacEwan Matthew R. , Tatman Lauren , Rogers John A. , Pet Mitchell A. 
Published: April 2022

AbstractSerial examination and direct measurement of intracompartmental pressure (ICP) are suboptimal strategies for the detection of acute compartment syndrome (CS) because they are operator‐dependent and yield information that only indirectly reflects intracompartmental muscle perfusion. As a result, instances of unnecessary fasciotomy and unrecognized CS are relatively common. Recently, near‐infrared spectroscopy (NIRS)‐based systems for compartment monitoring have generated interest as an adjunct tool. Under ideal conditions, NIRS directly measures the oxygenation of intracompartmental muscle (StO2), thereby obviating the challenges of interpreting equivocal clinical examination or ICP data. Despite these potential advantages, existing NIRS sensors are plagued by technical difficulties that limit clinical utility. Most of these limitations relate to their transcutaneous design that makes them susceptible to both interference from intervening skin/subcutaneous tissue, underlying hematoma, and instability of the skin‐sensor interface. Here, we present a flexible, wireless, Bluetooth‐enabled, percutaneously introducible intramuscular NIRS device that directly and continuously measures the StO2 of intracompartmental muscle. Proof of concept for this device is demonstrated in a swine lower extremity balloon compression model of acute CS, wherein we simultaneously track muscle oxygenation, ICP, and compartment perfusion pressure (PP). The observed StO2 decreased with increasing ICP and decreasing PP and then recovered following pressure reduction. The mean change in StO2 as the PP was decreased from baseline to 30 mmHg was −7.6%. The mean difference between baseline and nadir StO2 was −17.4%. Cross‐correlations (absolute value) describing the correspondence between StO2 and ICP were >0.73. This novel intramuscular NIRS device identifies decreased muscle perfusion in the setting of evolving CS.
Preparation and Characterization of Phosphoric Acid Doped Polyacrylamide/β‐Cyclodextrin High‐Temperature Proton Exchange Membrane
Authors: Chen Xiaoling , Wang Tian , Shi Caixin , Wang Guanhua , Zhao Yansheng , Liu Yongmei , Zhang Ding 
Published: April 2022

AbstractThe development of high‐temperature proton exchange membrane fuel cells calls for better membrane, and a polyacrylamide/β‐cyclodextrin hydrogel proton exchange membrane is prepared by solution polymerization of β‐cyclodextrin (β‐CD) and acrylamide (Am), for which ammonium persulfate (APS) and N, N″‐(methylene)bisacrylamide (MBA) is used as initiator and crosslinking agent, respectively. The observed proton conductivity of the membrane reaches 12.3 S m−1 at room temperature, when the ratio of β‐CD, APS, MBA to Am monomer is 0.42 mol%, 0.37 mol%, and 0.14 mol%, respectively, and the primary concentration of doped phosphoric acid is 8 mol L−1. The observed proton conductivity evolution on temperature obeys Arrhenius' law, indicating that the proton conduction mainly follows the hopping mechanism. In addition, the prepared PAM/β‐CD proton exchange membrane has a mass loss of only 8.47% at 205 °C, showing good thermal stability compared with PBI membrane. It also has good antioxidative stability as well as promising potential application in high‐temperature fuel cells.