bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical significance of dynamics between oxidative stress levels during mechanical lung ventilation in premature infants with persistent pulmonary hypertension
Authors: Klymenko Tetiana , Kononovych Mariia 
Published: August 2022

The aim of this study was to determine the clinical significance of the levels and dynamics of the urinary 8-hydroxy-2-deoxyguanosine, degree of pulmonary hypertension on choosing the duration and form of respiratory support in premature infants with respiratory distress syndrome in combination with perinatal asphyxia.
Materials and methods. The levels of the urinary 8-hydroxy-2-deoxyguanosine (8-OHdG), ng/ml were determined by enzyme immunoassay (ELISA) method and the degree of pulmonary hypertension (PH) - by echocardiography in 60 premature new-borns at 26-32 weeks of gestation on the 1st and the 3rd–5th days of life. A comparative analysis of indicators was carried out in 2 groups: I – 32 children with respiratory distress syndrome (RDS); II – 28 children with RDS combined with perinatal asphyxia. All infants received a respiratory support, depending on the clinical condition, blood gas analyses, and the chest X-ray.
Results. The level and dynamics of the urinary 8-OHdG correlated to degree of PH, form, and duration of respiratory support. Children of the group II on the 1st day of life had echocardiogram indicators of mild PH and indicators of the urinary 8-OHdG 2.27±0.39 ng/ml; by 3rd–5th days of life – level of the urinary 8-OHdG increased to 4.10±0.42 ng/ml and the level of PH – to moderate, required 76.2 % longer respiratory support compared to children of the group I.
Conclusions. Prematurely born infants with RDS in combination with perinatal asphyxia have a higher oxidative stress (OS) levels and more significant pulmonary hypertension, which requires a longer respiratory support by 76.2 % and more often use of high frequency oscillatory ventilation (HFOV) by 9.3 %
Educational example of masking textual information in a photographic signal
Authors: Holovin Mykola , Holovina Nina 
Published: August 2022

The paper presents a steganographic method of masking textual information in photo files. Concealment is implemented in Python. The introduction of individual letters of the text into the image is carried out by the method of "least significant bit". The program can be used for both educational and practical purposes. The Pillow graphics library was used to implement the program. This is not a specialized library for steganographic needs. The use of this library makes it possible to visualize the mechanism of hiding information in the lessons, while the conciseness of the program code gives the possibility to demonstrate it in the classroom setting. It is also important for educational purposes, that working within the Pillow library allows you to see the state of an empty and filled container at the level of individual bits. To assess the practical value of the program, it was tested with texts of different lengths and with containers (photographs) of various kinds. The experiment showed the correct reproduction of texts. Careful visual examination of the empty and correspondingly filled containers (photographs) revealed no differences or suspicions of text bookmarks. Of course, if the party who intercepted the masked message has guesses about how the text is hidden, then this text is easily revealed. Therefore, it is obvious, that the use of the program for practical purposes requires additional manipulations in the code, in particular related to the order of implementation of the text and the choice of location.
It is also desirable to additionally encrypt the text with at least a simple method. Such encryption is possible with the usage of a separate program. Analysis of photographs and manipulation with them at the level of individual bits also has educational value in terms of disclosing a method of capturing the corresponding physical signal. The latter gives an explanation of the methods of encoding static images, noise level, the magnitude of the useful physical signal, and the limits of sensitivity of human vision
The role and place of the discipline “History of mathematics in the 21st century”
Authors: Mesarosh Livia 
Published: August 2022

The key to the success of educational reform is a comprehensive and thorough training of future specialists in any field, with a broad scientific worldview and a high level of culture. For high-quality training of future professionals, a new stage has begun, characterized by the emergence of innovative technologies in the educational process. In higher educational institutions that train future specialists, there is an interest in the modernization of the educational process. The XXI century is a time of differentiation of sciences, earlier integral science was divided into smaller parts, new branches appeared, scientists specialized, individual researches give way to collective efforts. In such a whirlwind of events, the desire to study in detail and deeply any initial discipline, especially the history of its formation and development, is lost. In the absence of time, historical and mathematical information gradually becomes secondary, and should be consistent, clear, complete and arouse students' interest in the subject.
That is why it is important to emphasize some historical aspects of development, problems of teaching and learning, and possible ways to solve it in the discipline of "history of mathematics".
The research used methods of scientific knowledge: systematic and comparative analysis of literature, work programs, syllabi, pedagogical process on the problem of research, generalization and systematization.
It was found out, that the methods of teaching and learning have changed, although we have the opportunity to work with the latest computer technologies, but the role as an effective means of learning and the place as an integral part of the universal scientific heritage remain unchanged.
It is shown, that the history of mathematics will continue to serve as a discipline that is a kind of link between humanitarian, technical and natural sciences, contributes to the development of a scientific worldview and forms erudition
Implementation of project-based learning technology within the educational process of higher military institutions
Authors: Bhinder Nataliya , Protsenko Pavlo 
Published: August 2022

The article defines the category of project-based learning. It is an efficient pedagogical technology, oriented towards integration of theoretical knowledge from the different spheres of science, formation of professional skills, development of creativity, critical thinking, communication, leadership and decision-making. Also, project-based learning is a productive searching activity of cadets that is organized by an instructor to solve particular cognitive and practical tasks that is closely connected with future professional activity of learners.
We found that project-based learning technology is an important component of professional training of future military officers and it gives the possibility to use the person-centered approach, activate independent work and enhance cadets’ motivation to future professional activity.
The article investigates the types of projects in details. It is stated, that a number of projects are used, while implementing project-based learning technology during the educational process at the higher military institution. They are the following: construction and practical projects, role-plays and game projects, information and research projects, survey projects, productive projects, organization and creative projects. We have proved that the projects can also be divided into individual, personal, team and pair ones on the basis of participants; number. In addition, the projects can be short-term, middle-term, and long-term because of the duration of the activity.
The authors found that the project learning technology is realized in the four stages at the higher military institution: substantiation stage, searching stage, technological stage, and concluding stage. The article explains the kinds of work for each stage in details.
The notion of didactic conditions was outlined. The authors have proved that these conditions concern reasons and circumstances of realization of the educational process. Didactic conditions contribute to positive results of the process of professional training of future military officers. We decided that didactic conditions for implementation of project-based learning technology within the educational process at the higher military institution can be divided into the four stages: motivation, content, technological, and evaluation conditions. Each of these groups consists of specific didactic conditions, oriented towards the efficiency of project-based learning technology at the higher military institution
Analysis of ways to improve the efficiency of modern satellite communication systems
Authors: Trotsko Oleksandr 
Published: August 2022

Nowadays, the satellite segment in telecommunications occupies an important place and provides positioning of the global coverage system. However, the development of satellite technologies, compared to terrestrial wireless technologies, is slow. For example, the new DVB-S2 (Digital Video Broadcasting via Satellite) satellite standard contains a small number of improvements and refinements over the previous DVB-S standard. The main improvements are the introduction of codes with low density of LDPC (Low Density Parity Check) and the introduction of adaptive modulation and coding. Given the above, the object of research is modern satellite communication system. The subject of the research is the way to increase the efficiency of modern satellite communication systems. The research aims to analyze the feasibility of using a number of effective technologies in modern wireless systems, such as OFDM, UWB and MIMO, in satellite communication systems. The implementation of the considered options for the use of MIMO technology in satellite communication systems will increase the bandwidth and efficiency of these systems. However, there is a need for additional research to adapt this technology in satellite communication systems. Thus, the analysis allows forming the main directions of improving the efficiency of modern satellite communication systems. This analysis allows:
– to formulate new approaches to increase the efficiency of modern satellite communication systems;
– to substantiate new technological solutions for the construction of transceivers of satellite communication systems;
– to identify possible areas of research to improve the efficiency of modern satellite communication systems.
Development of a method of utilization of oil and gas industry waste at Pereshchepyno field (Ukraine)
Authors: Mykhailovska Olena , Zotsenko Mykola , Kulik Vladislav 
Published: August 2022

The object of research is the technological solutions for the construction of sludge barns at the Pereschepyno field (Ukraine). One of the most problematic places is the lack of reliable insulation of sludge barns and storage facilities.
The study used a screen type «wall in the soil» of elements of soil cement, which prevents the filtration of the aqueous phase. The screen was built monolithic. It is proposed to arrange the shade between the centers of the curtain equal to 0.8 of the diameter of the element. It is proposed to make elements from soil cement by the brown-mixing method. After 28 days (hardening of the elements) up to 60 % of the soil was removed from the waste storage area. This is due to the fact that the proposed method of arrangement of waste storage has a number of features. Over time, the strength and permeability of the aqueous phase of soil cement increase. It is proposed to fill the storage with drilling waste after the enclosing elements have hardened. In order for the soil to have a suitable humidity of 4–5 %, it is proposed to dry it outdoors. It is proposed to build a cover over the soil dump. If the optimum humidity of the mixture is not obtained after drying and mixing the waste with the soil, it is proposed to add a drying additive (ash removal of Mykolayiv thermal power plant). The amount of additive is from 1.5 to 3 % depending on the type of soil. Next, it is proposed to seal the layers of sludge and loam by rammers. After compaction, the operation is repeated. Compaction of soil layers is proposed to be carried out at optimum humidity. In comparison with similar known methods, this method provides the following advantages: low cost of manufacture due to the use of a waterproof layer of soil as the bottom of the structure; high water resistance – W12; high compressive strength; environmental safety and durability.
Modern determinants of consumer needs and analysis of the market of peloidotherapy in SPA resorts
Authors: Sarkisian Hanna , Liganenko Margaryta , Kambiz Sheida Golbad 
Published: August 2022

One of the directions of development of the tourism industry is health tourism. Today, having natural opportunities and high potential, it is possible to state the absence of highly competitive positions in this sector of the national economy of some developing countries. For example, in Ukraine, sanatorium-and-spa institutions are one of the priority areas for the development of domestic and foreign tourism, one of the most stable types of tourism markets. So, the object of the research is the Clinical Sanatorium named after V. I. Pirohov «Kuialnyk» (Odesa region, Ukraine). The subject of the research is ways to improve the Clinical Sanatorium named after V. I. Pirohov «Kuialnyk».
The available and potential reserves of medical resources, taking into account their qualitative and quantitative characteristics, can serve as the basis for the creation of such tourism products that are now very popular in the world, for example, the provision of spa services. The authors state the absence of highly competitive positions in this sector. In the current market conditions, the sanatorium business in Ukraine is undergoing structural changes. The branding scheme proposed by the authors of the Clinical Sanatorium named after V. I. Pirohov «Kuialnyk» allows improving the quality of spa services and marketing effectiveness. After all, the modern basis of the activity of tourist organizations is determined by the factor of informatization of society.
Since the vast majority of visitors to the resort are from Belarus, Moldova, it is interesting that the resort also has its share of international tourists from European countries (Romania, Bulgaria, Germany, etc.). Thanks to the successful identification of the strengths and needs of consumers, it can be assumed that the international tourist flow will increase, because there are all the necessary conditions for this. The new branding scheme developed by the authors will act as a catalyst and stimulator for the growth of the number of visitors to the Odesa region. The prospect of this study lies in the search for new solutions for the promotion, reorganization of SPA institutions in the market of health tourism services in Ukraine. The synergy of the optimal use of natural health-improving resources and the best management solutions for the use of information support create a competitive tourism product, which in turn will lead to an increase in international tourists.
O CORPO CRIANÇA E O CORPO ADULTO NA PESQUISA COM CRIANÇAS
Authors: Camargo Gisele Brandelero , Garanhani Marynelma Camargo 
Published: August 2022

Esse texto traz reflexões acerca do corpo criança e do corpo adulto na pesquisa com crianças. Pautados na experiência de uma pesquisa que ocorreu em 2018 e 2019, em duas instituições escolares de Ponta Grossa – Paraná, sendo um Centro Municipal de Educação Infantil (CMEI) e uma escola de anos iniciais do Ensino Fundamental. A investigação de base interpretativa e cunho etnográfico intentou compreender o ponto de vista das crianças sobre como é a experiência de atravessar da Educação Infantil para os Anos Iniciais do Ensino Fundamental. Os conceitos aqui discutidos visam colaborar com a legitimidade das vozes, verbais e não verbais da criança em pesquisas acadêmicas e científicas, em contexto educacional, pelo viés da Sociologia da Infância. Nesse interim, é apresentada a postura do menos adulto (MANDELL, 2003), como uma forma de relação entre o corpo adulto e o corpo criança no processo de produção de dados. Por meio dessa abordagem teórico metodológica, entende-se o corpo criança como um sujeito competente, criativo e produtor de conhecimento e cultura e defende-se a legitimidade de sua capacidade de compartilhar decisões, conjuntamente com o corpo adulto, no âmbito da pesquisa e do processo de escolarização.
Kidney Failure Alters Parathyroid Pin1 Phosphorylation and Parathyroid Hormone mRNA-Binding Proteins, Leading to Secondary Hyperparathyroidism
Authors: Hassan Alia , Pollak Yael E. , Kilav-Levin Rachel , Silver Justin , London Nir , Nechama Morris , Ben-Dov Iddo Z. , Naveh-Many Tally 
Published: August 2022

Significance Statement
Secondary hyperparathyroidism (SHP) is a common complication of CKD that when poorly controlled increases morbidity and mortality. In experimental models, the high serum parathyroid hormone (PTH) of SHP is due to increased PTH mRNA stability, mediated by changes in Protein-PTH mRNA interactions that are orchestrated by the isomerase Pin1. It is not known how CKD stimulates the parathyroid to dramatically increase PTH levels. We identify the CKD-induced post-translational modifications that disrupt parathyroid Pin1 isomerase activity and the effects on the Pin1 target and PTH mRNA decay-promoting protein, KSRP. We suggest that CKD-induced changes in Pin1, and hence sustained KSRP phosphorylation and protein-PTH mRNA interactions, are the driving force in overstimulation of the parathyroid glands in SHP.

Background
Secondary hyperparathyroidism (SHP) is a common complication of CKD that increases morbidity and mortality. In experimental SHP, increased parathyroid hormone (PTH) expression is due to enhanced PTH mRNA stability, mediated by changes in its interaction with stabilizing AUF1 and destabilizing KSRP. The isomerase Pin1 leads to KSRP dephosphorylation, but in SHP parathyroid Pin1 activity is decreased and hence phosphorylated KSRP fails to bind PTH mRNA, resulting in high PTH mRNA stability and levels. The up- and downstream mechanisms by which CKD stimulates the parathyroid glands remain elusive.

Methods
Adenine-rich high-phosphate diets induced CKD in rats and mice. Parathyroid organ cultures and transfected cells were incubated with Pin1 inhibitors for their effect on PTH expression. Mass spectrometry was performed on both parathyroid and PTH mRNA pulled-down proteins.

Results
CKD led to changes in rat parathyroid proteome and phosphoproteome profiles, including KSRP phosphorylation at Pin1 target sites. Furthermore, both acute and chronic kidney failure led to parathyroid-specific Pin1 Ser16 and Ser71 phosphorylation, which disrupts Pin1 activity. Pharmacologic Pin1 inhibition, which mimics the decreased Pin1 activity in SHP, increased PTH expression ex vivo in parathyroid glands in culture and in transfected cells through the PTH mRNA-protein interaction element and KSRP phosphorylation.

Conclusions
Kidney failure leads to loss of parathyroid Pin1 activity by inducing Pin1 phosphorylation. This predisposes parathyroids to increase PTH production through impaired PTH mRNA decay that is dependent on KSRP phosphorylation at Pin1-target motifs. Pin1 and KSRP phosphorylation and the Pin1-KSRP-PTH mRNA axis thus drive SHP.
The use of stimulation tests for the differential diagnosis of delayed puberty in boys. How to increase the specificity of the method?
Authors: Ioffe Irina Yu. , Skorodok Yulia L. , Plotnikova Elena V. , Nagornaya Irena I. , Nagovitsyna Ksenia O. , Jelenina Lyudmila A. 
Published: August 2022

BACKGROUND: In patients with a constitutional delay of puberty starts and ends completely without any medical intervention. In adolescents with hypogonadotropic hypogonadism puberty is absent or does not continue its development. Differential diagnosis of the conditions is complicated due to lack of standard recommendations for the selection, conducting and assessment of stimulation tests.
AIM: To assess the information content and find ways to increase the specificity of stimulation tests with triptorelin and corionic gonadotropin in relation to hypogonadotropic hypogonadism.
MATERIALS AND METHODS: We examined 44 adolescent boys aged 13.517 years with delayed puberty. Sexual development was assessed according to Tanner scale, bone age (X-ray of the non-dominant hand according to the Greulich atlas). All boys were tested with triptorelin. The test with one- and three-day intramuscular injection of human chorionic gonadotropin was performed in 26 and 35 patients, respectively. Statistical analysis was performed using the StatTech v. 2.6.1 (developer Stattech LLC, Russia). To assess the diagnostic significance of quantitative signs in predicting a certain outcome the ROC-curve analysis was performed.
RESULTS: It was revealed that a negative test with triptorelin was observed in some patients with constitutional delay of puberty. Threshold stimulated luteinizing hormone and follicle stimulating hormone levels were set (8.90 and 5.90 IU/l respectively). Gonadotropins values equal to or lower than selected thresholds allow diagnosing of hypogonadotropic hypogonadism with high sensitivity and specificity. Threshold testosterone levels stimulated by one- and three-day administration of human chorionic gonadotropin were determined (2.11 and 5.84 nmol/l respectively). Testosterone values equal to or lower than selected thresholds allow diagnosing of hypogonadotropic hypogonadism with high sensitivity and specificity. A high degree of positive correlation was found between stimulated luteinizing hormone levels and stimulated testosterone levels during a three-day test with human chorionic gonadotropin.
CONCLUSIONS: A negative test with triptorelin is observed in some patients with constitutional delay of puberty. The specificity of the test can be improved by using threshold stimulated levels of luteinizing hormone and follicle stimulating hormone (8.90 and 5.90 IU/L, respectively). The use of the threshold levels of testosterone (2.11 and 5.84 nmol/l within the one- and three-day functional tests of the testicles respectively) can help to increase the specificity of the considered outdated stimulation tests with human chorionic gonadotropin.