bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pengembangan Sekolah melalui Manajeman Talenta di SMK Negeri 1 Pitu
Authors: Arisma Deby - 
Published: November 2022

Pengembangan Sekolah melalui Manajeman Talenta
di SMK Negeri 1 Pitu
Lamijan
Email: lamijanfisika@gmail.com

Abstrak
Karya tulis ini dimaksudkan untuk memberikan gambaran mengenai: (1) pengembangan sekolah melalui manajemen talenta, dan (2)hasil atau dampak dari pelaksanaan program pengembangan sekolah melalui manajemen talenta. Karya tulis ini merupakan pengalaman pelaksanaan manajerial di SMK Negeri 1 Pitu dalam bentuk best practice. Pengalaman selama empat tahun melaksanakan program pengembangan sekolah melalui manajemen talenta terdiri atas: (1) pembentukan kesadaran warga sekolah untuk mengakui dan handarbeni sekolah, (2) pemberian peluang mengembangkan diri, (3) perwujudan kepuasan kerja sebagai dampak psikologis dari adanya pengakuan dan peluang, (4) perolehan kompensasi sebagai bentuk penghargaan yang diterima oleh warga sekolah sebagai akibat dari aktivitas-aktivitas pengembangan sekolah. Dampak dari pelaksanaan program pengembangan sekolah melalui manajemen talenta adalah: (1) terbentuknya kesadaran warga sekolah untuk handarbeni sekolah, memiliki keberanian dan keterbukaan dalam memberikan saran untuk kemajuan sekolah, (2) adanya pengembangan diri stakeholders untuk kemajuan sekolah yang ditandai terjalinnya kerjasama sinergis antara sekolah dengan warga sekolah dan berbagai pihak baik dari dalam maupun luar negeri, (3) terwujudnya kepuasan kerja stakeholders sebagai dampak peningkatan prestasi sekolah dalam ranah kognitif, afektif, dan psikomotor, serta (4) adanya perolehan kompensasi yang berupa finansial dan perasaan senang, bangga, dan nyaman menjadi bagian dari SMKN 1 Pitu.

Kata Kunci: Pengembangan, Manajemen Talenta
Pendampingan Pengolahan Pupuk Organik Limbah Ternak Sapi di Kelompok Ternak Surowani
Authors: Alifia Putriya , Sanjaya Lucky , Asmoro Novian Wely , Nainggolan David Maruli , Siswanto Wahyu , Komariah Ainur 
Published: November 2022

ABSTRACTTiyaran, Bulu, Sukoharjo Regency has potential in the agricultural and livestock sectors. One of the service partners is the Surowani who has problems with livestock waste management. The purpose of the service activities carried out by the PPK Ormawa team of Universitas Veteran Bangun Nusantara is to improve the skills of partners in managing livestock waste.. This activity was carried out in several stages, namely mentoring and approaches in the form of discussions, counseling, demonstrations and direct practice related to the manufacture of organic fertilizer from cow dung waste. The results of the service activities concluded that public knowledge about cattle waste treatment increased up to 90%, and the ability to practice composting from cattle waste reached 80%. Keywords: cattle waste, compost, community service, organic fertilizer
The Effectiveness of The Use Game Based Learning on Student's Motivation and Learning Outcomes in Camera Movement Engineering Materials
Authors: Marcella Chellsy 
Published: November 2022

The shift of conventional learning media to more modern learning media is a must for the world of education to be able to adapt to the development of science and technology. This study was conducted to analyse the effectiveness of the use of game-based learning on motivation and student learning outcomes on the subject of camera movement techniques. Data collection uses tests to measure learning outcomes and checks to measure learning motivation. The data analysis technique uses normalized gain (N-Gain). The application of the game-based learning model also improves learning outcomes. The average value of the pre-test was 76.41 and increased at the post test of 90.28. Based on the KKM score, 37 people or 94.9% have completed learning. This shows that there is an increase in learning outcomes seen from the average value. The average value of normalized gain (N-Gain) is 0.60, so the game-based learning quizzes method is quite effective in improving learning outcomes. Teachers should reduce the lecture method by increasing the active play method.
Creating a Sense of Place in Online Learning
Authors: Mahatmi Mesti Woro 
Published: November 2022

Since the increase of Covid 19 cases, the government has affirmed the implementation of online learning for all students, including university students. Online learning is a learning process conducted in a network that utilizes the internet, without face-to-faceinteractions. In practice, online learning has many obstacles which affect the success of students in the courses. Creating a sense of place in online learning can be done by improving communication between lecturers and students: humanization of students, the socialization process related to online learning, the importance of the role of lecturers in online learning, the contribution of students in online learning, learning media, guidelines and learning targets. With a conducive learning atmosphere, optimizing the role of lecturers and student contributions, can meet the desired learning targets.Efforts are made to achieve effective communication. The success of learning depends on the lecturers and students, each of which has a role that cannot be ruled out. The role of technology has a significant effect on the online learning process, such as internet access, communication media, and learning media.In the end, this effective communication effort is expected to be able to encouragestudents to play a maximum role in online learning, especially in situations where face-to-face learning is not possible, such as during a pandemic.
US-CHINA RELATIONS: TRADE WAR AND THE QUEST FOR GLOBAL HEGEMONY
Authors: Lee Pei May , Zulkefli Nina Nurasyekin 
Published: November 2022

This article attempts to provide an alternative perspective on the US-China trade war by integrating power transition theory and the concept of soft power in examining the nature of the trade war and conditions that fuelled it. The discussion also includes the possibility of the emergence of a new global order led by China beyond the trade war. This study used a qualitative approach by analysing primary and secondary sources such as speeches of representatives from both China and the US, books, journal articles, newspaper articles and research by both national and international organisations. The findings revealed that the main trigger of the trade war was not trade deficits or unfair practices, as other literature has suggested, but rather a desire by the US to prevent the decline of American hegemony. We argue that there are three reasons why China cannot form a new global order and replace the US as a global hegemon within the next decade. First, following the trade war, there is growing wariness about Chinese firms and investments, globally. Second, China’s soft power is relatively ineffective, and its culture less appealing to Third World countries as compared to the US’s. Finally, unlike the US, China does not have a strong and expansive network of allies supporting its quest for global leadership.
Pharmacophore Based Virtual Screening and Docking of Different Aryl Sulfonamide Derivatives of 5HT7R Antagonist
Authors: Fatema Nahid , Manga Vijjulatha , Yamini Lingala , Khan Salman Ahmad , Ullah Qasim 
Published: November 2022

The selective blockade of 5HT7R (5-hydroxytryptamine 7 receptor) displays an antidepressant-like activity. It is a Gs-coupled receptor, which inactivates the adenyl cyclase enzyme or activates the potassium ion channel. Structural information of 5HT7 was obtained by homology modeling using MODELLER v.9.13. In the present study, pharmacophore-based virtual screening, molecular docking, and binding free energy calculations were performed on a series of antagonist aryl sulphonamide derivatives. A five-point pharmacophore hypothesis with two hydrogen bond acceptor (A), one hydrogen bond donor (D), one positive group (p), and one ring (R) was developed with acceptable R2 and Q2 values of 0.90 and 0.602, respectively. Eventually, common pharmacophore hypothesis-based screening was conducted against Asinex databases. Finally, binding free energy and dock score analysis was carried out for the top hits obtained from the docking process. All 14 hits from the database in this study had a satisfactory dock score and binding energy values within the best active compound range. H bond interaction with amino acid residues Ser212 and π-π stacking with Tyr249 were investigated for the best active molecule. Both are present in the top hits, including other interactions as well.
Molecular Docking Screening and Pharmacokinetic Studies of Some Boron-Pleuromutilin Analogues against Possible Targets of Wolbachia pipientis
Authors: Ugbe Fabian Audu , Shallangwa Gideon Adamu , Uzairu Adamu , Abdulkadir Ibrahim 
Published: November 2022

Lymphatic filariasis and onchocerciasis are two common filarial diseases caused by a group of parasitic nematodes called filarial worms, which co-habit with the bacteria organism Wolbachia. One good treatment approach seeks Wolbachia as a drug target. Here, a computer-aided molecular docking screening was conducted on a series of 52 pleuromutilin analogs against four Wolbachia enzymes: α-DsbA1 (PDB: 3F4R), α-DsbA2 (6EEZ), OTU deubiquitinase (6W9O), and cytoplasmic incompatibility factor CidA (7ESX) to find a more potent drug candidate(s) for the treatment of filarial diseases. The docking investigation was performed using the iGEMDOCK tool, while NAMD was utilized for the Molecular Dynamic (MD) simulation. The results of the virtual screening identified four ligand-protein interaction pairs with the highest binding affinities in the order: 17_6W9O (-117.31 kcal/mol) > 28_6EEZ (-104.43 kcal/mol) > 17_7ESX (-102.56 kcal/mol) > 41_7ESX (-101.51 kcal/mol), greater than that of the reference drug doxycycline_7ESX (-92.15 kcal/mol). These molecules (17, 28, and 41) showed excellent binding interactions, making very close contact with the receptors’ amino acid residues. They also showed better pharmacokinetic properties than doxycycline because they showed high intestinal absorption, were orally bioavailable and showed no AMES toxicity. Also, the stability of 17_6W9O interactions was confirmed by the MD simulation. Therefore, the selected molecules could be developed as potential drug candidates for treating filarial diseases.
A study of wheat-weed response and economical analysis to fertilization and post-emergence herbicides under arid climatic conditions
Authors: Sarita  , Singh Ishwar , Mehriya Moti Lal , Samota M. K. 
Published: November 2022

A two-year field experiment was conducted in two consecutive rabi seasons under arid climatic conditions to examine the effect of different fertility levels and herbicides on weed dynamics and the performance of wheat (Triticum aestivumL.). Results revealed that a significantly minimum weed dry weight was recorded with 75% RDF (Recommended Dose of Fertilizer) (90-30 kg N-P2O5/ha). Application of 100% RDF (120-40 kg N-P2O5/ha) recorded significantly higher weed dry weight at 35 DAS (Days After Sowing) (16.50 g/m2) and harvest (28.15 g/m2), growth and yield attributesi.e.plant height (89.14 cm), crop dry matter accumulation (300.8 g/meter row length), crop growth rate (17.08 g/m2/day), leaf area index at 50 DAS (3.06, net assimilation rate 50-75 DAS, length of the spike (13.36 cm), number of grains/spike (41.52), grain yield (4083 kg/ha), straw yield (5019 kg/ha) and biological yield (9103 kg/ha) over 75% RDF. This treatment remains at par with 125% RDF (150-50 kg N-P2O5/ha) except for the leaf area index at 75 DAS. Among the herbicidal treatments, application of the ready-to-use herbicides clodinafop-propargyl 15% + metsulfuron methyl 1% @ 64 g/ha provided a superior value of weed indicesi.e.higher weed control efficiency (91.30), crop resistance-index, and herbicide efficiency-index, and lower weed-index (1.91) over other herbicides. This treatment also exhibited significantly higher plant height (92.33 cm), crop dry matter accumulation (325.5g/meter row length), crop growth rate (16.49 g/m2/day), leaf area index (3.15), net assimilation rate, length of the spike (14.28 cm), number of spike/meter row length (153.0), number of grains/spike (44.52), grain yield (4374 kg/ha), straw yield (5381 kg/ha) and biological yield (9755 kg/ha) over weedy check plot, which was followed by sulfosulfuron 75% + metsulfuron methyl 5% @ 32 g/ha, both of which remained statistically at par with each other except for the number of grains/spike. The application of 100% RDF and clodinafop-propargyl 15% + metsulfuron methyl 1% @ 64 g/ha recorded higher net returns and maximum B: C ratio.
Clinical and economic impact of coronary artery bypass graft and percutaneous coronary intervention in young individuals with acute coronary syndromes and multivessel disease: A real-world comparison in a middle-income country
Authors: Alexim Gustavo de Almeida , Rocha Luiza Ferreira , Dobri Giovani Prediger , Rosa Júnior Adair da Silva , Reis Ricardo Torres Bispo , Nogueira Ana Claudia Cavalcante , Soares Alexandre Anderson de Souza Munhoz , Sposito Andrei Carvalho , de Paula Ana Patricia , de Carvalho Luiz Sérgio Fernandes 
Published: November 2022

BackgroundIn recent decades, the world watched a dramatic increase in the incidence of acute coronary syndromes (ACS) among young individuals (≤55 years-old) and a relative decrease in the elderly. The management of ACS in young patients with multivessel disease still needs to be elucidated, as these individuals maintain a long life expectancy.Research QuestionTo compare clinical outcomes and care costs in individuals with premature ACS and multivessel disease undergoing coronary artery bypass graft surgery (CABG) or percutaneous coronary intervention (PCI).Methods and ResultsParticipants included all individuals ≤55 years-old admitted with ACS to public hospitals in Brasília (Brazil) between 2013 and 2015 and who underwent cardiac catheterization with SYNTAX score ≥23 or Duke category 6. Outcomes were adjudicated with death certificates and data from medical records. The primary outcome was the occurrence of major adverse cardiovascular events (MACE), defined as death due to cardiovascular causes, recurrent hospitalizations due to cardiovascular ischemic events, and incident heart failure New York Heart Association III-IV. As secondary outcome we assessed indirect and direct costs by evaluating the cost of lost productivity (in international dollars (Int$) per year) due to illness and death, outpatient costs and costs with new hospitalizations. Multivariate and principal components (PC) adjusted analyzes were performed.ResultsAmong 1,088 subjects (111 CABG and 977 PCI) followed for 6.2 years (IQR: 1.1), 304 primary events were observed. MACE was observed in 20.7% of the CABG group and 28.8% of the PCI group (p = 0.037). In multivariate analyses, PCI was associated with a hazard ratio (HR) = 1.227 (95% CI: 1.004–1.499; p = 0.0457) for MACE, and in PC-adjusted HR = 1.268 (95% CI: 1.048–1.548; p = 0.0271) compared with CABG. Despite direct costs were equivalent, the cost due to the loss of labor productivity was higher in the PCI group (Int$ 4,511 (IQR: 18,062)/year vs Int$ 3,578 (IQR: 13,198)/year; p = 0.049], compared with CABG.ConclusionsAmong young individuals with ACS and multivessel disease, surgical strategy was associated with a lower occurrence of MACE and lower indirect costs in the long-term.
Endocrine system after 2 years of COVID-19 vaccines: A narrative review of the literature
Authors: Pezzaioli Letizia Chiara , Gatta Elisa , Bambini Francesca , Facondo Paolo , Gava Maria , Cavadini Maria , Buoso Caterina , Di Lodovico Elena , Rotondi Mario , Ferlin Alberto , Cappelli Carlo 
Published: November 2022

PurposeThe purpose of this study was to describe the current knowledge on the potential endocrine adverse effects post-COVID-19 vaccines.MethodsA PubMed/MEDLINE, Web of Science, and Scopus research was performed. Case reports, case series, original studies, and reviews written in English and published online up to 31 July 2022 were selected and reviewed. The final reference list was defined based on the relevance of each paper to the scope of this review.ResultsThe available data showed that endocrine side effects are generally rare and with favorable outcome, being thyroid disorders the most common. Conversely, data on type 1 diabetes mellitus are rare; adrenal and pituitary events are even anecdotal. Finally, the available clinical studies suggest no impact on female reproductive system and on male and couple fertility.ConclusionOverall, these data show that, after 2 years of COVID-19 vaccines, the endocrine system is not heavily threatened.
Spatial-temporal variation characteristics of cultivated land and controlling factors in the Yangtze River Delta region of China
Authors: Huo Kun , Ruan Yunfeng , Fan Haizhou , Guo Chunhui , Cai Hong 
Published: November 2022

Comprehending the change characteristics and controlling factors of regional cultivated land resources is one of the important preconditions for their healthy development. The main objective of this study is to analyze the spatial–temporal variation characteristics of cultivated land and controlling factors in the Yangtze River Delta region. Thus, the mathematical–statistical, land use dynamic degree model, principal component analysis, and geographically weighted regression model were used to analyze the change in cultivated land area and social–economic factors in the Yangtze River Delta region from 2009 to 2018. The results showed that the cultivated land area and per capita cultivated land area had a decreasing trend from 2009 to 2018, decreasing by 8.5 × 104 ha and 0.0039 ha, respectively. From the perspective of spatial patterns, the rapidly decreasing areas of cultivated land were mainly distributed in the southeast, while the slowly decreasing areas of cultivated land were becoming concentrated in the northwest, and the slowly increasing areas presented as scattered distribution, which was also the same spatial distribution for the per capita cultivated land area in the Yangtze River Delta region. Among these factors, population (POP) and the total power of agricultural mechanization (TPAM) had a positive spatial correlation with cultivated land. The gross domestic product (GDP) had a negative spatial correlation with cultivated land, which revealed that cultivated land was intensely affected by human activities. Moreover, the spatial distribution and influence degree of the controlling factors differed in regions. Our research is expected to reveal the relationship between economic development and cultivated land protection for providing references for strengthening regional cultivated land management, maintaining the healthy development of regional resources, and rational utilization of cultivated land.
HOXA-AS2 may be a potential prognostic biomarker in human cancers: A meta-analysis and bioinformatics analysis
Authors: Zhang Fan , Zhang Guangming , Zhang Helin , Pu Xingyu , Chi Fei , Zhang Dengxiao , Xin Xiaoming , Gao Mingxuan , Luo Wenyuan , Li Xingyong 
Published: November 2022

Background: Dysregulation of long non-coding (lncRNA) has been reported in various solid tumors. HOXA cluster antisense RNA 2 (HOXA-AS2) is a newly identified lncRNA with abnormal expression in several human malignancies. However, its prognostic value remains controversial. This meta-analysis synthesized available data to clarify the association between HOXA-AS2 expression levels and clinical prognosis in multiple cancers.Methods: Four public databases (Embase, PubMed, Web of Science, The Cochrane Library) were used to identify eligible studies. Hazard ratios (HRs) and odds ratios (ORs) with their 95% confidence intervals (CIs) were combined to assess the correlation of HOXA-AS2 expression with survival outcomes and clinicopathological features of cancer patients. Publication bias was measured using Begg’s funnel plot and Egger’s regression test, and the stability of the combined results was measured using sensitivity analysis. Additionally, multiple public databases were screened and extracted to validate the results of this meta-analysis.Results: The study included 20 studies, containing 1331 patients. The meta-analysis showed that the overexpression of HOXA-AS2 was associated with poor overall survival (HR = 2.06, 95% CI 1.58–2.69, p &lt; 0.001). In addition, the high expression of HOXA-AS2 could forecast advanced tumor stage (OR = 3.89, 95% CI 2.90–5.21, p &lt; 0.001), earlier lymph node metastasis (OR = 3.48, 95% CI 2.29–5.29, p &lt; 0.001), larger tumor size (OR = 2.36, 95% CI 1.52–3.66, p &lt; 0.001) and earlier distant metastasis (OR = 3.54, 95% CI 2.00–6.28, p &lt; 0.001). However, other clinicopathological features, including age (OR = 1.09, 95% CI 0.86–1.38, p = 0.467), gender (OR = 0.92, 95% CI 0.72–1.18, p = 0.496), depth of invasion (OR = 2.13, 95% CI 0.77–5.90, p = 0.146) and differentiation (OR = 1.02, 95% CI 0.65–1.59, p = 0.945) were not significantly different from HOXA-AS2 expression.Conclusion: Our study showed that the overexpression of HOXA-AS2 was related to poor overall survival and clinicopathological features. HOXA-AS2 may serve as a potential prognostic indicator and therapeutic target for tumor treatment.
Integrative multiomics evaluation reveals the importance of pseudouridine synthases in hepatocellular carcinoma
Authors: Jin Zhipeng , Song Mengying , Wang Jianping , Zhu Wenjing , Sun Dongxu , Liu Huayuan , Shi Guangjun 
Published: November 2022

Background: The pseudouridine synthases (PUSs) have been reported to be associated with cancers. However, their involvement in hepatocellular carcinoma (HCC) has not been well documented. Here, we assess the roles of PUSs in HCC.Methods: RNA sequencing data of TCGA-LIHC and LIRI-JP were downloaded from the Cancer Genome Atlas (TCGA) and the International Cancer Genome Consortium (ICGC), respectively. GSE36376 gene expression microarray was downloaded from the Gene Expression Omnibus (GEO). Proteomics data for an HBV-related HCC cohort was obtained from the CPTAC Data Portal. The RT-qPCR assay was performed to measure the relative mRNA expression of genes in clinical tissues and cell lines. Diagnostic efficiency was evaluated by the ROC curve. Prognostic value was assessed using the Kaplan-Meier curve, Cox regression model, and time-dependent ROC curve. Copy number variation (CNV) was analyzed using the GSCA database. Functional analysis was carried out with GSEA, GSVA, and clusterProfiler package. The tumor microenvironment (TME) related analysis was performed using ssGSEA and the ESTIMATE algorithm.Results: We identified 7 PUSs that were significantly upregulated in HCC, and 5 of them (DKC1, PUS1, PUS7, PUSL1, and RPUSD3) were independent risk factors for patients’ OS. Meanwhile, the protein expression of DKC1, PUS1, and PUS7 was also upregulated and related to poor survival. Both mRNA and protein of these PUSs were highly diagnostic of HCC. Moreover, the CNV of PUS1, PUS7, PUS7L, and RPUSD2 was also associated with prognosis. Further functional analysis revealed that PUSs were mainly involved in pathways such as genetic information processing, substance metabolism, cell cycle, and immune regulation.Conclusion: PUSs may play crucial roles in HCC and could be used as potential biomarkers for the diagnosis and prognosis of patients.