bluuebunny/crossref_metadata_2025_split huggingface dataset:
A single session of exercise reduces blood pressure reactivity to stress: a systematic review and meta-analysis
Authors: Mariano Igor M. , Amaral Ana Luiza , Ribeiro Paula A. B. , Puga Guilherme M. 
Published: July 2022

AbstractStressful situations are common in everyday life and disturb homeostasis. So, an exercise session is a strategy to mitigate blood pressure (BP) peaks in response to stress (i.e., BP reactivity), decreasing the cardiovascular risk. This is a systematic review and meta-analysis that aims to verify the effects of a single session of physical exercises on BP reactivity to stress in adults. The searches were performed in digital databases (MEDLINE, LILACS, EMBASE, SPORTDiscus, and PsycInfo) and 29 studies were included, totaling 795 individuals (quantitative analysis: k = 25, n = 659). As for exercise characteristics, 21 of the 29 studies focused on aerobic exercises, and 23 studies focused on low to moderate intensities. As for the stress tests, we have them in the following order from the most to the least frequent: stroop color and word test, cold pressor test, arithmetic test, public speaking, handgrip, trier social stress test, and study task. Favorable metanalytic results (standardized mean differences through random-effects approach) for the exercises were found, with attenuated reactivity in systolic BP (pooled effect size = − 0.38 [− 0.49; − 0.27], representing average reductions of 3.7 ± 3.8 mmHg), diastolic BP (pooled effect size = − 0.51 [− 0.70; − 0.33], representing average reductions of 2.9 ± 3.7 mmHg), and mean BP (pooled effect size = − 0.51 [− 0.72; − 0.31], representing average reductions of 4.1 ± 3.3 mmHg). So, acute physical exercise lowers systolic, diastolic, and mean blood pressure reactivity in response to stressor tasks. However, given the small magnitude of effects, the clinical relevance of this result must be interpreted with caution and be better explored.
Edge betweenness centrality as a failure predictor in network models of structurally disordered materials
Authors: Pournajar Mahshid , Zaiser Michael , Moretti Paolo 
Published: July 2022

AbstractNetwork theoretical measures such as geodesic edge betweenness centrality (GEBC) have been proposed as failure predictors in network models of load-driven materials failure. Edge betweenness centrality ranks which links are significant, based on the fraction of shortest paths that pass through the links between network nodes. We study GEBC as a failure predictor for two-dimensional fuse network models of load transmission in structurally disordered materials. We analyze the evolution of edge betweenness centrality in the run-up to failure and the correlation between GEBC and failure propensity for both hierarchical and non-hierarchical networks exhibiting various degrees of disorder. We observe a non trivial relationship between GEBC and failure propensity, which suggests that the idea of GEBC as a useful failure predictor needs to be strongly qualified.
Prospective assessment using 18F-FDG PET/CT as a novel predictor for early response to PD-1 blockade in non-small-cell lung cancer
Authors: Yamaguchi Ou , Kaira Kyoichi , Naruse Ichiro , Umeda Yukihiro , Honda Takeshi , Watanabe Satoshi , Ichikawa Kosuke , Tateishi Kazunari , Kasahara Norimitsu , Higuchi Tetsuya , Hashimoto Kosuke , Shinomiya Shun , Miura Yu , Shiono Ayako , Mouri Atsuto , Imai Hisao , Iizuka Kunihiko , Ishizuka Tamotsu , Minato Koichi , Suda Satoshi , Kagamu Hiroshi , Mori Keita , Kuji Ichiei , Seki Nobuhiko 
Published: July 2022

AbstractAnti-programmed death-1 (PD-1) blockade is a standard treatment for advanced non-small-cell lung cancer (NSCLC). However, no appropriate modality exists for monitoring its therapeutic response immediately after initiation. Therefore, we aimed to elucidate the clinical relevance of 18F-FDG PET/CT versus CT in predicting the response to PD-1 blockade in the early phase. This prospective study included a total of 54 NSCLC patients. 18F-FDG PET/CT was performed at 4 weeks and 9 weeks after PD-1 blockade monotherapy. Maximum standardized uptake values (SULmax), metabolic tumor volume (MTV), and total lesion glycolysis (TLG) were evaluated. Among all patients, partial metabolic response and progressive metabolic disease after PD-1 blockade were observed in 35.2% and 11.1% on SULmax, 22.2% and 51.8% on MTV, and 27.8% and 46.3% on TLG, respectively, whereas a partial response (PR) and progressive disease (PD), respectively, based on RECIST v1.1 were recognized in 35.2% and 35.2%, respectively. The predictive probability of PR (MTV: 57.9% vs. 21.1%, p = 0.044; TLG: 63.2% vs. 21.1%, p = 0.020) and PD (MTV: 78.9% vs. 47.3%, p = 0.002; TLG: 73.7% vs. 21.1%, p = 0.007) detected based on RECIST at 4 weeks after PD-1 blockade initiation was significantly higher using MTV or TLG on 18F-FDG uptake than on CT. Multivariate analysis revealed that metabolic response by MTV or TLG at 4 weeks was an independent factor for response to PD-1 blockade treatment. Metabolic assessment by MTV or TLG was superior to morphological changes on CT for predicting the therapeutic response and survival at 4 weeks after PD-1 blockade.
Bitter taste receptor T2R38 is expressed on skin-infiltrating lymphocytes and regulates lymphocyte migration
Authors: Sakakibara Moe , Sumida Hayakazu , Yanagida Keisuke , Miyasato Sosuke , Nakamura Motonao , Sato Shinichi 
Published: July 2022

AbstractBitter taste receptors (T2Rs) are G protein-coupled receptors involved in the perception of bitter taste on the tongue. In humans, T2Rs have been found in several sites outside the oral cavity. Although T2R38 has been reported to be expressed on peripheral lymphocytes, it is poorly understood whether T2R38 plays immunological roles in inflammatory skin diseases such as atopic dermatitis (AD). Then, we first confirmed that T2R38 gene expression was higher in lesional skin of AD subjects than healthy controls. Furthermore, skin T2R38 expression levels were correlated with serum thymus and activation-regulated chemokine and IgE levels in AD patients. In lesional skin of AD, section staining revealed that CD3+ T cells in the dermis were T2R38 positive. In addition, flow cytometry analysis showed T2R38 expression in skin T cells. Migration assays using T2R38-transduced Jurkat T cell leukemia cells revealed that T2R38 agonists exerted a dose-dependent migration inhibitory effect. Moreover, skin tissue extracts, as well as supernatants of cultured HaCaT keratinocytes, caused T2R38-dependent migration inhibition, indicating that there should be an endogenous ligand for T2R38 in the skin epidermis. These findings implicate T2R38 as a migratory inhibitory receptor on the skin-infiltrating lymphocytes and as a therapeutic target for allergic/inflammatory skin diseases.
Mycobacterium intracellulare induces a Th17 immune response via M1-like macrophage polarization in canine peripheral blood mononuclear cells
Authors: Kim Suji , Hyun You-Seok , Park Hong-Tae , Shin Min-Kyung , Yoo Han Sang 
Published: July 2022

AbstractMycobacterium avium-intracellulare complex (MAC) is one of the most prevalent pathogenic nontuberculous mycobacteria that cause chronic pulmonary disease. The prevalence of MAC infection has been rising globally in a wide range of hosts, including companion animals. MAC infection has been reported in dogs; however, little is known about interaction between MAC and dogs, especially in immune response. In this study, we investigated the host immune response driven by M. intracellulare using the co-culture system of canine T helper cells and autologous monocyte-derived macrophages (MDMs). Transcriptomic analysis revealed that canine MDMs differentiated into M1-like macrophages after M. intracellulare infection and the macrophages secreted molecules that induced Th1/Th17 cell polarization. Furthermore, canine lymphocytes co-cultured with M. intracellulare-infected macrophages induced the adaptive Th17 responses after 5 days. Taken together, our results indicate that M. intracellulare elicits a Th17 response through macrophage activation in this system. Those findings might help the understanding of the canine immune response to MAC infection and diminishing the potential zoonotic risk in One Health aspect.
The molecular basis of cereal grain proteostasis
Authors: Cao Hui , Duncan Owen , Millar A. Harvey 
Published: July 2022

Abstract
Storage proteins deposited in the endosperm of cereal grains are both a nitrogen reserve for seed germination and seedling growth and a primary protein source for human nutrition. Detailed surveys of the patterns of storage protein accumulation in cereal grains during grain development have been undertaken, but an in-depth understanding of the molecular mechanisms that regulate these patterns is still lacking. Accumulation of storage proteins in cereal grains involves a series of subcellular compartments, a set of energy-dependent events that compete with other cellular processes, and a balance of protein synthesis and protein degradation rates at different times during the developmental process. In this review, we focus on the importance of rates in cereal grain storage protein accumulation during grain development and outline the potential implications and applications of this information to accelerate modern agriculture breeding programmes and optimize energy use efficiency in proteostasis.
Identifying Language Disorder in Bilingual Children Using Automatic Speech Recognition
Authors: Albudoor Nahar , Peña Elizabeth D. 
Published: July 2022

Purpose:
The differential diagnosis of developmental language disorder (DLD) in bilingual children represents a unique challenge due to their distributed language exposure and knowledge. The current evidence indicates that dual-language testing yields the most accurate classification of DLD among bilinguals, but there are limited personnel and resources to support this practice. The purpose of this study was therefore to determine the feasibility of dual-language automatic speech recognition (ASR) for identifying DLD in bilingual children.

Method:

Eighty-four Spanish–English bilingual second graders with (
n
= 25) and without (
n
= 59) confirmed diagnoses of DLD completed the Bilingual English-Spanish Assessment–Middle Extension Morphosyntax in both languages. Their responses on a subset of items were scored manually by human examiners and programmatically by a researcher-developed ASR application employing a commercial speech-to-text algorithm.

Results:

Results demonstrated moderate overall item-by-item scoring agreement (
k
= .54) and similar classification accuracy values (human = 92%, ASR = 88%) between the two methods using the best-language score. Classification accuracy of the ASR method increased to 94% of cases correctly classified when test items with poorer discrimination in the ASR condition were eliminated.

Conclusion:
This study provides preliminary support for the technical feasibility of ASR as a bilingual expressive language assessment tool.

Supplemental Material:

https://doi.org/10.23641/asha.20249994
DMA‐Net: Dual multi‐instance attention network for X‐ray image classification
Authors: Liu Shuoyan , Yang Enze , Liu Yuxin , Zhao Shitao 
Published: July 2022

AbstractSecurity inspection has been playing a critical role in protecting public space from safety threats. As object detection is a fundamental and mature research filed, it still suffers from numerous challenges such as scale, viewpoint and intra‐class variance of X‐ray images. The main reasons are, mis‐modeling of actual security inspection as well as insufficient effective X‐ray samples. To this end, the X‐ray inspection task is reconsidered by predicting the dangerous attributes without boxes and categories, a Dual Multi‐instance Attention network (DMA‐Net) is proposed in this paper to mine the key‐instance from both patch and proposal branch. In patch‐level multi‐instance attention pooling, Recursive Attention Pyramid (RAP) and Spatial‐Channel Attention (SCA) are proposed to effectively learn discriminative representation from hierarchical features. Meanwhile, the proposal‐level multi‐instance attention pooling selectively emphasizes interdependent of crucial regions. The features of dual pooling layers are fused to predict dangerous attributes of X‐ray inspection images directly. Further, this paper contributes a large‐scale and high‐quality X‐ray image dataset from railway stations, named Railway Station X‐ray (RSXray). Enormous experiments on RSXray, GDXray and SIXray demonstrate that the proposed DMA‐Net achieves surprising performance with dual multi instance learning diagrams and attention mechanism. The superiority of the employed framework for applications in real world scenarios are also verified.
Effects of Resistance Priming Exercise on Within-day Jumping
Performance and its Relationship with Strength Level
Authors: González-García Jaime , Latella Christopher , Aguilar-Navarro Millán , Romero-Moraleda Blanca 
Published: July 2022

AbstractThis study aimed to identify the effects of same-day resistance priming exercise
on countermovement jump parameters and subjective readiness, and to identify
whether baseline strength level influenced these outcomes. Fourteen participants
performed two separate conditions (Priming [2 sets high-load parallel squats
with a 20% velocity loss cut-off] and Control) in a randomized,
counterbalanced crossover design. Countermovement jump was assessed at pre, post
and 6 h while readiness was assessed at pre and at 6 h only. All
countermovement jump force-time metrics were similar between conditions
(p>0.05), but different individual responses were noted
6 h after priming. Jump height was increased for 4/14, decreased
for another 4/14, and maintained for 6/14 participants at
6 h. Higher perceived physical performance capability
(p<0.001) and activation balance (p=0.005) were
observed after priming only. Positive relationships were observed between
strength and the percentage change in jump height (r=0.47–0.50;
p=0.033–0.042), concentric peak velocity
(r=0.48–0.51; p=0.030–0.041) and
impulse (r=0.47; p=0.030–0.045) at
post and 6 h after priming exercise. These findings suggest that
velocity-based high-load low-volume priming exercise has potential to positively
impact jump performance and subjective readiness later that day in certain
individuals. Participant absolute strength level may influence this response but
should be confirmed in subsequent studies.
Arcade Sutures to Minimize Ear Displacement in Rhytidectomy
Authors: Abraham Manoj T. , Klimczak Jaclyn A. , Hart Hannah , Hu Shirley , Abraham-Aggarwal Minali 
Published: July 2022

AbstractEar deformities after rhytidectomy are not uncommon and have a significant impact on cosmetic success. We postulate the use of horizontal mattress suspension sutures in the anterior face anchored to the deep temporalis fascia (DTF) during rhytidectomy allows for a vertical lift while minimizing the risk to the frontal branch of the facial nerve and decreasing forward rotation of the ear. To compare auricular displacement during rhytidectomy using an arcade of horizontal mattress suspension sutures anchored to the DTF instead of the preauricular pre-parotid fascia, and evaluate outcomes with this modification at 1 year. This was a proof of concept prospective cohort study of 20 patients (40 sides) undergoing rhytidectomy by a single plastic surgeon (level of evidence 4). Intraoperative measurements were taken to determine the amount of auricular displacement with suspension sutures placed in the preauricular fascia compared with the DTF. To confirm longevity, we compared ear position preoperatively and at 1 year after rhytidectomy with our technique. There was significantly less auricular displacement when superficial musculoaponeurotic system (SMAS) suspension sutures were placed in the DTF 0.75 ± 0.69 mm compared with the preauricular fascia 9.71 ± 2.57 mm (p < 0.00001). With our technique at an average follow-up of 370.3 days, there was no significant change in auricular rotation compared with preoperative photos (p = 0.125).Our simple rhytidectomy modification allows for vertical resuspension of the SMAS in the anterior face in a safe manner while minimizing displacement of the auricle.
Inhibiting Interleukin-6/Signal Transducers and Activators of Transduction-3/Hypoxia-Inducible Factor-1α Signaling Pathway Suppressed the Growth of Infantile Hemangioma
Authors: Maimaiti Aziguli , Aierken Yeerfan , Zhou Ling , He Jun , Abudureyimu Abudusaimi , Li Shui-Xue 
Published: July 2022

Abstract
Objective This study aims to evaluate the expression of interleukin 6 (IL-6) in patients with infantile hemangioma (IH) and investigate the role of the IL-6/signal transducers and activators of transduction-3 (STAT3)/hypoxia-inducible factor-1α (HIF-1α) pathways in the progression of IH.
Methods Serum samples were obtained from the patients with IH and normal infants to measure IL-6 expression. Hemangioma-derived stem cells (HemSCs) were transfected with small interfering RNA (siRNA) targeting IL-6, HIF-1α, or STAT3. Then, cell viability and wound healing assays were conducted. After that, the HemSC tumor mouse model was established. The in vivo anticancer effect of the IL-6 inhibitor was investigated.
Results The patients with IH had much higher IL-6 levels compared with the healthy controls (p = 0.005). HemSCs transfected with IL-6 siRNA had significantly lower viability and migration rates than normal HemSCs. HemSCs transfected with STAT3 siRNA or HIF-1α siRNA had similar tendencies. On tumor-bearing mice, the IL-6 inhibitor treatment significantly delayed tumor growth. Compared with the control group, caspase-3 was significantly increased in the IL-6 inhibitor group (p < 0.05), whereas Ki-67 was decreased in the IL-6 inhibitor group (p < 0.05). In the terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) assay, the IL-6 inhibitor group had much higher apoptosis rates than the controls (p < 0.05).
Conclusion Our findings indicate that inhibiting the IL-6/STAT3/HIF-1α signaling pathways could suppress IH growth.
Frequency-segmented power amplification using multi-band radio frequency amplifiers to produce a high-voltage pulse
Authors: Togawa Kazuaki , Maesaka Hirokazu , Kobana Reichiro , Tanaka Hitoshi 
Published: July 2022

A method of frequency-segmented power amplification using multiband radio frequency (RF) amplifiers was proposed to generate stable and arbitrary high-voltage pulses. The concept behind this method is that an arbitrary pulse with a specified duration and sharp edges can be reconstructed using only several frequencies, and most of the power is concentrated on the fundamental frequency. The high-voltage pulse can, therefore, be obtained by amplifying each segmented frequency and then combining it with the RF power combiners. To correct the frequency-dependent group delays and gain of the amplifier circuit and to perform fine-tuning of the pulse structure, a seed pulse is divided into several lines that have bandpass filters, variable delay lines, variable power attenuators, and main RF amplifiers. A prototype pulse amplifier was designed and fabricated based on this method to generate rectangular pulses for the electron beam chopper of an x-ray free-electron laser injector. Flat and stable pulses with a 2 ns width of 0.2 kV height, peak-to-peak flat top of 0.8%, and route-mean-squared peak jitter of less than 0.2% were successively generated in both single- and multi-bunch structures. In the future, this type of pulse generator will play an important role in accelerators that require complicated and precise beam handling at high repetition rates of kHz or MHz.
Negative Schottky barrier height and surface inhomogeneity in n-silicon M–I–S structures
Authors: Harisha C. P. , Liao M.-H. , Kei C.-C. , Joshi S. 
Published: July 2022

The alleviation effect on the Schottky barrier height (SBH) (ΦB) using ultrathin titanium dioxide and hafnium dioxide dielectrics in a single layer and a bilayer stack was demonstrated. ΦB in the Pt/n-Si contact was reduced from 0.53 to −0.058, 0.3, and −0.12 eV using 3 nm TiO2, 1 nm HfO2, and high-k/high-k bilayer insertion, respectively. A maximum of 122% reduction in ΦB was obtained using bilayer dielectric insertion, which is the highest ever reduction reported so far in a Schottky diode. This was achieved by effectively passivating the semiconductor surface states by HF cleaning followed by inserting an ultrathin film produced from the novel Atomic Layer Deposition (ALD) technique. The Gaussian distribution (GD) of barrier heights all over the interface has been investigated for both Metal–Semiconductor (M–S) and Metal–Insulator–Semiconductor (M–I–S) contacts. The nonlinear behavior in a conventional Richardson plot was observed with lower values of the Richardson constant (A*). We have reported the surface inhomogeneity in both M–S and M–I–S contacts through temperature dependency of diode characteristics. The standard deviation (σ) as evidence for the Gaussian distribution of barrier heights was determined using the ln(Is/T2) vs q/2kT plot. The results were validated by a modified Richardson plot where the values of A* obtained were found to be in close agreement with the known values. As the ALD technique is known for conformity and uniformity of thin films, the dielectric insertion has proved effective in mitigating the SBH. However, the inhomogeneity in both M–S and M–I–S points to the role of dipole formation at the interface.
Liquid-cooled modular gas cell system for high-order harmonic generation using high average power laser systems
Authors: Filus Zoltán , Ye Peng , Csizmadia Tamás , Grósz Tímea , Gulyás Oldal Lénárd , De Marco Massimo , Füle Miklós , Kahaly Subhendu , Varjú Katalin , Major Balázs 
Published: July 2022

We present the design and implementation of a new, modular gas target suitable for high-order harmonic generation using high average power lasers. To ensure thermal stability in this high heat load environment, we implement an appropriate liquid cooling system. The system can be used in multiple-cell configurations, allowing us to control the cell length and aperture size. The cell design was optimized with heat and flow simulations for thermal characteristics, vacuum compatibility, and generation medium properties. Finally, the cell system was experimentally validated by conducting high-order harmonic generation measurements using the 100 kHz high average power HR-1 laser system at the Extreme Light Infrastructure Attosecond Light Pulse Source (ELI ALPS) facility. Such a robust, versatile, and stackable gas cell arrangement can easily be adapted to different experimental geometries in both table-top laboratory systems and user-oriented facilities, such as ELI ALPS.
Highly dispersed platinum deposited on nitrogen-doped vertical graphene array for efficient electrochemical hydrogen evolution
Authors: Yang Hongzhou , Yang Zhaojun , Han Zhaojun , Chu Dewei , Chen Chaoqiu , Xie Xiaoying , Shang Lu , Zhang Tierui 
Published: July 2022

Abstract
The electrochemical hydrogen evolution is a key technology for future renewable energy conversion and storage. Platinum is the most efficient catalyst for hydrogen evolution reaction (HER), but its mass activity should be boosted further. Herein, we deposited platinum on nitrogen-doped vertical graphene through an atomic layer deposition method. Aberration-corrected high-angle annular dark-field scanning transmission electron microscopy confirmed that the platinum was highly dispersed on the array substrate. On account of the array structure and high dispersion of platinum, the synthesized catalyst exhibited high HER performance with a low overpotential of 42 mV at 10 mA cm−2 and a low Tafel slope of 52.2 mV dec−1. Significantly, the synthesized catalyst exhibited a high mass activity of 4.45 A mg−1
Pt, which was ∼13 times higher than that of commercial Pt/C.