bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prevalence of idiopathic scoliosis in athletes: a systematic review and meta-analysis
Authors: Mousavi Leila , Seidi Foad , Minoonejad Hooman , Nikouei Farshad 
Published: August 2022

ObjectiveThis study aimed to determine the prevalence of idiopathic scoliosis (IS) in child, adolescent and adult athletes of all sports activity levels.DesignSystematic review with meta-analysis.Data sourcesElectronic databases (PubMed, Scopus, ProQuest, Sage journals, ScienceDirect, Google Scholar and Springer) were systematically searched up from inception to 28 September 2021.Eligibility criteria for selecting studiesObservational investigations were included to evaluate the prevalence of IS in athletes (engaged in any type of individual and team sports). Congenital scoliosis, neuromuscular scoliosis, Scheuermann’s kyphosis and de novo scoliosis were not included. The risk of bias was assessed using the tool developed by Hoyet al.ResultsTwenty-two studies were included (N=57 470, range 15–46544, participants), thirteen studies were of high-quality. The estimated prevalence of IS in athletes was 27% (95% CI 20% to 35%, I2=98%), with a 95% prediction interval (1% to 69%). The prevalence of IS was significantly higher in female athletes (35%, 95% CI 27% to 34%, I2=98%). Ballet dancers showed a high IS prevalence (35%, 95% CI 24% to 47%, I2=98%). Recreational athletes showed a higher IS prevalence (33%, 95% CI 24% to 43%, I2=98%) than at competitive-level athletes (0.05%, 95% CI 0.03% to 0.08%, I2=98%), followed by elite (20%, 95% CI 13% to 27%, I2=98%).ConclusionsThe prevalence of IS in athletes was similar or higher to that as seen in other studies of the general population. IS prevalence may have a U-shaped relationship relative to level of competition. Further studies are required to determine which sports have the highest IS prevalence.
Women’s attitudes towards a human papillomavirus-based cervical cancer screening strategy: a systematic review
Authors: Nothacker Julia , Nury Edris , Roebl Mathieu Marianne , Raatz Heike , Meerpohl Joerg J , Schmucker Christine 
Published: August 2022

ObjectiveTo provide insights into women’s attitudes towards a human papillomavirus (HPV)-based cervical cancer screening strategy.Data sourcesMedline, Web of Science Core Collection, Cochrane Library, PsycINFO, CINAHL and ClinicalTrials.gov were systematically searched for published and ongoing studies (last search conducted in August 2021).Methods of study selectionThe search identified 3162 references. Qualitative and quantitative studies dealing with women’s attitudes towards, and acceptance of, an HPV-based cervical cancer screening strategy in Western healthcare systems were included. For data analysis, thematic analysis was used and synthesised findings were presented descriptively.Tabulation, integration, and resultsTwelve studies (including 9928 women) from USA, Canada, UK and Australia met the inclusion criteria. Women’s attitudes towards HPV-based screening strategies were mainly affected by the understanding of (i) the personal risk of an HPV infection, (ii) the implication of a positive finding and (iii) the overall screening purpose. Women who considered their personal risk of HPV to be low and women who feared negative implications of a positive finding were more likely to express negative attitudes, whereas positive attitudes were particularly expressed by women understanding the screening purpose. Overall acceptance of an HPV-based screening strategy ranged between 13% and 84%.ConclusionThis systematic review provides insights into the attitudes towards HPV-based cervical cancer screening and its acceptability based on studies conducted with women from USA, Canada, UK and Australia. This knowledge is essential for the development of education and information strategies to support the implementation of HPV-based cervical cancer screening.Systematic review registrationPROSPERO (CRD42020178957).
Targeting the extra domain A of fibronectin for cancer therapy with CAR-T cells
Authors: Martín-Otal Celia , Lasarte-Cia Aritz , Serrano Diego , Casares Noelia , Conde Enrique , Navarro Flor , Sánchez-Moreno Inés , Gorraiz Marta , Sarrión Patricia , Calvo Alfonso , De Andrea Carlos E , Echeveste José , Vilas Amaia , Rodriguez-Madoz Juan Roberto , San Miguel Jesús , Prosper Felipe , Hervas-Stubbs Sandra , Lasarte Juan Jose , Lozano Teresa 
Published: August 2022

BackgroundOne of the main difficulties of adoptive cell therapies with chimeric antigen receptor (CAR)-T cells in solid tumors is the identification of specific target antigens. The tumor microenvironment can present suitable antigens for CAR design, even though they are not expressed by the tumor cells. We have generated a CAR specific for the splice variant extra domain A (EDA) of fibronectin, which is highly expressed in the tumor stroma of many types of tumors but not in healthy tissues.MethodsEDA expression was explored in RNA-seq data from different human tumor types and by immunohistochemistry in paraffin-embedded tumor biopsies. Murine and human anti-EDA CAR-T cells were prepared using recombinant retro/lentiviruses, respectively. The functionality of EDA CAR-T cells was measured in vitro in response to antigen stimulation. The antitumor activity of EDA CAR-T cells was measured in vivo in C57BL/6 mice challenged with PM299L-EDA hepatocarcinoma cell line, in 129Sv mice-bearing F9 teratocarcinoma and in NSG mice injected with the human hepatocarcinoma cell line PLC.ResultsEDA CAR-T cells recognized and killed EDA-expressing tumor cell lines in vitro and rejected EDA-expressing tumors in immunocompetent mice. Notably, EDA CAR-T cells showed an antitumor effect in mice injected with EDA-negative tumor cells lines when the tumor stroma or the basement membrane of tumor endothelial cells express EDA. Thus, EDA CAR-T administration delayed tumor growth in immunocompetent 129Sv mice challenged with teratocarcinoma cell line F9. EDA CAR-T treatment exerted an antiangiogenic effect and significantly reduced gene signatures associated with epithelial-mesenchymal transition, collagen synthesis, extracellular matrix organization as well as IL-6-STAT5 and KRAS pathways. Importantly, the human version of EDA CAR, that includes the human 41BB and CD3ζ endodomains, exerted strong antitumor activity in NSG mice challenged with the human hepatocarcinoma cell line PLC, which expresses EDA in the tumor stroma and the endothelial vasculature. EDA CAR-T cells exhibited a tropism for EDA-expressing tumor tissue and no toxicity was observed in tumor bearing or in healthy mice.ConclusionsThese results suggest that targeting the tumor-specific fibronectin splice variant EDA with CAR-T cells is feasible and offers a therapeutic option that is applicable to different types of cancer.
Single-cell transcriptomics reveals shared immunosuppressive landscapes of mouse and human neuroblastoma
Authors: Costa Ana , Thirant Cécile , Kramdi Amira , Pierre-Eugène Cécile , Louis-Brennetot Caroline , Blanchard Orphée , Surdez Didier , Gruel Nadege , Lapouble Eve , Pierron Gaëlle , Sitbon Deborah , Brisse Hervé , Gauthier Arnaud , Fréneaux Paul , Bohec Mylène , Raynal Virginie , Baulande Sylvain , Leclere Renaud , Champenois Gabriel , Nicolas Andre , Meseure Didier , Bellini Angela , Marabelle Aurelien , Geoerger Birgit , Mechta-Grigoriou Fatima , Schleiermacher Gudrun , Menger Laurie , Delattre Olivier , Janoueix-Lerosey Isabelle 
Published: August 2022

BackgroundHigh-risk neuroblastoma is a pediatric cancer with still a dismal prognosis, despite multimodal and intensive therapies. Tumor microenvironment represents a key component of the tumor ecosystem the complexity of which has to be accurately understood to define selective targeting opportunities, including immune-based therapies.MethodsWe combined various approaches including single-cell transcriptomics to dissect the tumor microenvironment of both a transgenic mouse neuroblastoma model and a cohort of 10 biopsies from neuroblastoma patients, either at diagnosis or at relapse. Features of related cells were validated by multicolor flow cytometry and functional assays.ResultsWe show that the immune microenvironment of MYCN-driven mouse neuroblastoma is characterized by a low content of T cells, several phenotypes of macrophages and a population of cells expressing signatures of myeloid-derived suppressor cells (MDSCs) that are molecularly distinct from the various macrophage subsets. We document two cancer-associated fibroblasts (CAFs) subsets, one of which corresponding to CAF-S1, known to have immunosuppressive functions. Our data unravel a complex content in myeloid cells in patient tumors and further document a striking correspondence of the microenvironment populations between both mouse and human tumors. We show that mouse intratumor T cells exhibit increased expression of inhibitory receptors at the protein level. Consistently, T cells from patients are characterized by features of exhaustion, expressing inhibitory receptors and showing low expression of effector cytokines. We further functionally demonstrate that MDSCs isolated from mouse neuroblastoma have immunosuppressive properties, impairing the proliferation of T lymphocytes.ConclusionsOur study demonstrates that neuroblastoma tumors have an immunocompromised microenvironment characterized by dysfunctional T cells and accumulation of immunosuppressive cells. Our work provides a new and precious data resource to better understand the neuroblastoma ecosystem and suggest novel therapeutic strategies, targeting both tumor cells and components of the microenvironment.
Fungal endophytes affecting the health and recovery of Long’s Braya (Braya longii) and Fernald’s Braya (Braya fernaldii), endangered endemic species of Newfoundland, Canada
Authors: de la Bastide Paul Y. , Finston Terrie , Hermanutz Luise , Hintz Will 
Published: August 2022

Long’s ( Braya longii Fernald) and Fernald’s ( B. fernaldii Abbe) Braya are endemic to the Great Northern Peninsula of Newfoundland, Canada. These herbaceous perennials are endangered due to habitat loss and degradation, as well as ongoing threats from fungal infections and insect herbivory. While recovery plans are being implemented, the identity of pathogenic fungi and their origins remain largely unknown. This study was initiated to describe the associated fungal community and infection symptoms. Plant tissues from three populations were sampled over 5 years yielding 326 fungal isolates identified primarily by nucleotide sequence analysis of the internal transcribed spacer rDNA region. Isolates included 36 taxa, 16 of which were detected once and 5 detected three times or less. In contrast, 12 taxa were detected across multiple sites, sampling intervals and years. These included two species of Alternaria, Boeremia exigua, closely related species of the Didymellaceae, Botrytis cinerea, Fusarium sp., Colletotrichum sp., Stagonosporopsis sp., Pleospora sp., and Truncatella angustata. Some common taxa showed seasonal trends. The isolated fungi included known pathogens of Brassicaceae. The plants in this study frequently showed symptoms indicative of fungal infection and insect herbivory. These findings improve our knowledge of Braya endophyte communities and will inform recovery efforts for these endangered species.
Automated dynamic schema generation using knowledge graph
Authors: Singh Priyank Kumar , Ur Rehman Sami , J Darshan , G Shobha , N Deepamala 
Published: August 2022

<span>On the internet where the number of database developers is increasing with the availability of huge data to be stored and queried. Establishing relations between various schemas and helping the developers by filtering, prioritizing, and suggesting relevant schema is a requirement. Recommendation system plays an important role in searching through a large volume of dynamically generated schemas to provide database developers with personalized schemas and services. Although many methods are already available to solve problems using machine learning, they require more time and data to learn. These problems can be solved using knowledge graphs (KG). This paper investigates building knowledge graphs to recommend schemas. </span>
Open bibliographic data and the Italian National Scientific Qualification: Measuring coverage of academic fields
Authors: Bologna Federica , Di Iorio Angelo , Peroni Silvio , Poggi Francesco 
Published: August 2022

Abstract
The importance of open bibliographic repositories is widely accepted by the scientific community. For evaluation processes, however, there is still some skepticism: Even if large repositories of open access articles and free publication indexes exist and are continuously growing, assessment procedures still rely on proprietary databases, mainly due to the richness of the data available in these proprietary databases and the services provided by the companies they are offered by. This paper investigates the status of open bibliographic data of three of the most used open resources, namely Microsoft Academic Graph, Crossref, and OpenAIRE, evaluating their potentialities as substitutes of proprietary databases for academic evaluation processes. We focused on the Italian National Scientific Qualification (NSQ), the Italian process for university professor qualification, which uses data from commercial indexes, and investigated similarities and differences between research areas, disciplines, and application roles. The main conclusion is that open data sets are ready to be used for some disciplines, among them mathematics, natural sciences, economics, and statistics, even if there is still room for improvement; but there is still a large gap to fill in others—such as history, philosophy, pedagogy, and psychology—and greater effort is required from researchers and institutions.
Measuring and interpreting the differences of the nations’ scientific specialization indexes by output and by input
Authors: Abramo Giovanni , D’Angelo Ciriaco Andrea , Di Costa Flavia 
Published: August 2022

Abstract
This paper compares the national scientific profiles of 199 countries in 254 fields, tracked by two indices of scientific specialization based respectively on indicators of input and output. For each country, the indicator of inputs considers the number of researchers in each field. The output indicator, named Total Fractional Impact, based on the citations of publications indexed in the Web of Science, measures the scholarly impact of knowledge produced in each field. For each country, the approach allows us to measure the deviations between the two profiles, thereby revealing potential differences in research efficiency and/or capital allocation across fields, compared to benchmark countries.
Father Anastasius Odaye Dogli (1888–1970) and the Inception of Indigenous Catholic Clergy in Ghana
Authors: Mensah Michael Kodzo 
Published: August 2022

Abstract
The historiography of the inception of the Catholic Church in Ghana has focused largely on the activities of the European missionaries. This has left a gap in our knowledge regarding their first indigenous collaborators and their contribution. This is particularly the case of the Rev Fr Anastasius Odaye Dogli (1888–1970), the first indigenous Catholic priest of the Gold Coast about whom only scant literature exists. This article seeks to complement the work of earlier mission historiographers, by retrieving archival material from various sources in Ghana, Togo, and Italy, and sets out to retrieve his narrative blurred by a hundred years of legends that have emerged through oral tradition. It examines the challenges and struggles of a young African who broke through stereotypical, cultural, and colonial barriers to lay the foundations for a centenary of indigenous Roman Catholic clergy in Ghana.
Self-Benefit and Others’ Benefit in Cooperative Behavior in Shared Space
Authors: Matsubayashi Shota , Miwa Kazuhisa , Terai Hitoshi , Shimojo Asaya , Ninomiya Yuki 
Published: August 2022

Objective The objective is to clarify the nature of cooperative moving behavior that realizes smooth traffic with others from the viewpoint of the trade-off between self-benefit and others’ benefit in the shared space. Background The shared space is not constrained by formal rules or behavioral norms, and is a potentially ambiguous situation where it is not clear who has priority. Therefore, the nature of cooperative behavior in the shared space is unclear. Method An experimental task was conducted to compare cooperative and nonurgent moving behavior regarding completion time (self-benefit), the amount of interruption (others’ benefit), and the amount of operation (cognitive effort). Results First, cooperative behavior benefits others. Second, although cooperative behavior decreases self-benefit compared to the baseline without any instructions, it can obtain relatively more self-benefit than nonurgent behavior without considering self-benefit. Third, cooperative behavior requires cognitive effort. Conclusion Cooperative behavior provides benefit to both oneself and others by spending cognitive effort in not interrupting others. Application If the nature of the cooperative behavior can be clarified, a cooperative module can be implemented into the algorithms of various mobilities.
Treatment of congenital auricle malformation with EarWell Ear Correction Kit: A meta-analysis
Authors: Wu Dan , Li Liang , Zhou Ming 
Published: August 2022

Objective The effectiveness of EarWell Ear Correction Kit in the treatment of congenital auricle malformation and the incidence of complications are not particularly clear, so we carried out this study to provide a better reference for plastic surgeons to use EarWell Ear Correction Kit in the treatment of congenital auricle malformation. Methods We searched the Chinese and English databases including PubMed, Embase, the Cochrane Library, China National Knowledge Infrastructure, Wanfang, and VIP information databases. Results Through this meta-analysis, we found that the effective rate of EarWell Ear Correction Kit was 89.1%. The incidence of complications using EarWell Ear Correction Kit for correction of congenital auricular deformity was 11.4%. In terms of complications, the incidence of skin lesions was 9% and the incidence of dermatitis was 3.4%. Conclusion EarWell Ear Correction Kit has high efficiency in the correction of congenital auricular deformity and a low incidence of complications. It can be used for the treatment of congenital auricular deformity in patients within 6 months of birth.
Elbow flexion contractures in neonatal brachial plexus palsy: A one-year comparison of dynamic orthosis and serial casting
Authors: Op de Coul L.S. , Bleeker S. , de Groot J.H. , Nelissen R.G.H.H. , Steenbeek D. 
Published: August 2022

Objective Elbow flexion contractures are common complications of neonatal brachial plexus palsy, but evidence on how to treat these contractures is weak. This study compared the treatment of elbow flexion contractures using a dynamic orthosis or serial circular casting. Methods A randomized controlled trial was conducted with one-year follow-up. Children with an elbow flexion contracture of ≥30° were treated with either a night-worn dynamic orthosis for one year or serial casting for four weeks followed by night splinting. For pragmatic reasons, some participants were included in an open part of this study, this group was also analyzed separately. Degree of contracture and goal attainment scaling was evaluated at baseline and after 8, 20 and 54 weeks. Results 55 patients were analyzed in this trial, 32 of whom were randomized to treatment. At one-year follow-up of the randomized group, both dynamic splinting (median −8.5°, interquartile range [IQR] −13.5, −5) and serial casting (median −11.0°, IQR −16, −5) resulted in significant reduction of contracture ( P < 0 .001). The reduction was significantly greater with serial casting in the first 20 weeks, but not at one-year follow-up ( P = 0.683). In the entire cohort, the individual functional goals had been reached in 24 out of 32 cases (80%) of dynamic splinting and 18 out of 23 cases (82%) of serial casting, respectively. Conclusion The dynamic night orthosis is comparable to serial casting for treating elbow flexion contractures in children with brachial plexus birth injury. We recommend selecting one of these treatment modalities in close consultation with parents and patients.
Sensitivity of the SNNOOP10 list in the high-risk secondary headache detection
Authors: García-Azorín David , Abelaira-Freire Jaime , González-García Nuria , Rodriguez-Adrada Esther , Schytz Henrik Winther , Barloese Mads , Guerrero Ángel Luis , Porta-Etessam Jesús , Martín-Sánchez Francisco Javier 
Published: August 2022

Aim To evaluate the diagnostic accuracy of the SNNOOP10 list in the detection of high-risk headaches. Methods Patients that visited the Hospital Clínico San Carlos (Madrid) emergency department due to headache that were allocated to a Manchester Triage System level between critical and urgent were prospectively included but retrospectively analysed. A researcher blind to the patients’ diagnosis administered a standardised questionnaire and afterwards a neurologist blind to the questionnaire results diagnosed the patient according to the International Classification of Headache Disorders. The primary endpoint was to assess the sensitivity of the SNNOOP10 list in the detection of high-risk headaches. Secondary endpoints included the evaluation of the sensitivity, specificity, positive predictive value, negative predictive value and area under the curve of each SNNOOP10 item. Results Between April 2015 and October 2021, 100 patients were included. Patients were 44 years old (inter-quartile range: 33.6–64.7) and 57% were female. We identified 37 different diagnoses. Final diagnosis was a primary headache in 33%, secondary headache in 65% and cranial neuralgia in 2%. There were 46 patients that were considered as having high-risk headache. Patients from the primary headache group were younger and more frequently female. Sensitivity of SNNOOP10 list was 100% (95% confidence interval: 90.2%–100%). The items with higher sensitivity were neurologic deficit or disfunction (75.5%), pattern change or recent onset of the headache (64.4%), onset after 50 years (64.4%). The most specific items were posttraumatic onset of headache (94.5%), neoplasm in history (89.1%) and systemic symptoms (89%). The area under the curve of the SNNOOP10 list was 0.66 (95% CI: 0.55–0.76). Conclusion The red flags from the SNNOOP10 list showed a 100% sensitivity in the detection of high-risk headache disorders.