bluuebunny/crossref_metadata_2025_split huggingface dataset:
Are the neglected tropical diseases under control in the tri-border region between Brazil, Argentina, and Paraguay?
Authors: Mendes Oliveira Filipa , Arcêncio Ricardo , Moraes Arcoverde Marcos Augusto , Fronteira Inês 
Published: April 2022

Introduction: Implementation of prevention and control measures for communicable diseases in border regions can be challenging and lead to inefficient attempts to control them. We describe evidences on the strengths, weaknesses, opportunities and challenges regarding implementation of health interventions for control, prevention and treatment of selected neglected tropical diseases (NTD), a group of transmissible diseases typically prevalent in tropical countries and vulnerable populations, in the tri-border between Brazil, Argentina, and Paraguay.
Methodology: A systematic literature review of observational and experimental studies was conducted, using PubMed and Bireme databases. Eligibility criteria were location (tri-border area) and subject (health interventions).
Results: Of a total of 595 references identified, 34 studies were included (18 pertaining to leishmaniasis, 11 to dengue, 2 to leprosy, 2 to soil-transmitted helminthiases and 1 to Chagas’ disease), with an inclusion rate of 6.4%. The main strengths were the similarity of health interventions between countries and easiness of mobility and communication flows. The main weaknesses were access to rural areas and discrepancies in the number of studies between countries. As for opportunities, we identified increased tourism, economic development and recent increasing research in this field. The main challenges were the absence of studies regarding other prevalent NTD in the region and movement of goods, animals and people across borders.
Conclusions: Although epidemiological studies are still needed to better understand and assess the prevalence of NTD in the area, mainly in Paraguay, these findings can inform decision-makers and health managers to plan a common strategy to address NTD.
Changing characteristics of cancer patients during the COVID-19 pandemic
Authors: Korkusuz Ramazan , Sahingoz Erdal Gulcin , Kibar Akilli Isil , Bilge Müge , Tural Deniz , Kart Yasar Kadriye 
Published: April 2022

Introduction: Cancer patients are more sensitive to infections, and, compared to other patients, may have more serious outcomes. Thus, cancer patients are a high-risk group in the COVID-19 pandemic. The aim of this study was to evaluate how cancer patients are affected by COVID-19 infection; the prevalence, and factors affecting mortality.
Methodology: This single-centre, retrospective study included cancer patients under follow-up treatment at our hospital with a laboratory-confirmed diagnosis of COVID-19. Demographic and clinical data were obtained from electronic medical records. The effects of tumour subtype and patient demographic data on COVID-19 prevalence and mortality were analyzed using univariate and multivariate models.
Results: Evaluation was made of 217 cancer patients, comprising140 (64.5%) males and 77 (35.5%) females with a mean age of 62.05 ± 12.95 years. Mortality was seen in 84 (38.7%) patients. Disease grade, chemotherapy within the last 3 months and CT findings were determined to be related to mortality. In logistic regression analysis, the most important factors affecting survival were determined to be severe lung involvement (p < 0.001) and hematological malignancy.
Conclusions: It is clear that cancer patients are at greater risk from COVID-19 infection than individuals without a malignant disease. The results showed that cancer patients with different tumour types had different levels of sensitivity to COVID-19. It is clear that with ongoing viral mutations, the duration of the pandemic is unknown. Therefore, the continuation of cancer screening and cancer treatments should not be interrupted.
Molecular identification of Giardia spp. in Latin America: An updated systematic review on reports from 2017 to 2021
Authors: Sarria-Guzmán Yohanna , Chávez-Romero Yosef , Bernal Jaime Eduardo , González-Jiménez Francisco Erik , Serrano-Silva Nancy , Fusaro Carmine 
Published: April 2022

Background: Giardia spp. is the most common protozoan found in coproparasitoscopic tests; it is the cause of gastrointestinal discomfort, with a high prevalence in children and in low-income areas. This systematic review updates available literature on molecular identification of Giardia spp. in Latin America during 2017 to 2021.
Methodology: The guidelines established in Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) were used; the study covers the period from January 1, 2017 to October 03, 2021; the search focused on the “molecular identification of Giardia spp. in Latin America” in six different scientific databases. The material found was reviewed to select only those papers that met the inclusion and exclusion criteria.
Results: The search yielded 1036 publications, but only 19 investigations in 6 countries (Brazil, Colombia, Cuba, Ecuador, Mexico, and Venezuela) met the selection criteria. Most were cross-sectional studies carried out in school-age children, the dominant assemblages were A and B while the most frequent subassemblages were AII, BIII and BIV, the most used target genes were tpi and gdh, the prevalence by molecular methods was higher regarding microscopy, the countries with the highest prevalence percentages for Giardiosis were Brazil and Cuba.
Conclusions: More Latin America countries need to generate data of prevalence, incidence, and intensity of Giardiosis. Studies are also needed to estimate the costs of Giardiosis on economic productivity and public health. The present systematic review offers evidence based on the current literature available for the molecular identification of Giardia spp. in Latin America during 2017 to 2021.
Nortriptyline overcomes corticosteroid resistance in NK and NKT-like cells from peripheral blood of patients with chronic obstructive pulmonary disease
Authors: Kadushkin Aliaksei G. , Tahanovich Anatoli D. , Movchan Lyudmila V. , Dziadzichkina Volha V. , Levandovskaya Olga V. , Shman Tatsiana V. 
Published: April 2022

Introduction: An antidepressant nortriptyline potentiates glucocorticoid (GC) action with synergistic suppression of inflammatory mediator release, but the precise molecular mechanism is unknown.
Materials and methods: Peripheral blood cells from patients with chronic obstructive pulmonary disease (COPD) (n = 21) were incubated with nortriptyline (1 μM or 10 μM), budesonide (10 nM), or their combinations, followed by stimulation with phorbol myristate acetate (PMA) and ionomycin. Cytokine production, glucocorticoid receptor β (GRβ), histone deacetylase 2 (HDAC2) and histone H4 acetylation of K8 (HAT) expression, p65 NF-kB and p38 mi­togen-activated protein kinase (p38 MAPK) phosphorylation in NK (CD3-CD56+) and NKT-like (CD3+CD56+) cells were analyzed by flow cytometry.
Results: We observed that nortriptyline (10 μM) significantly attenuated the effects of PMA/ionomycin on the synthe­sis of interferon γ (IFNγ), interleukin 4 (IL-4), and IL-8, expression of GRβ and HAT, as well as p65 NF-kB and p38 MAPK phosphorylation in NK and NKT-like cells, whereas nortriptyline (1 μM) only inhibited IL-4 production by NK and NKT-like cells.
Discussion: The combination of nortriptyline (10 μM) and budesonide decreased IFNγ, tumor necrosis factor α, IL-4, IL-8, and GRβ expression, as well as phosphorylated p38 MAPK and p65 NF-κB levels by NK and NKT-like cells above that of budesonide alone. Furthermore, the same association of drugs enhanced HDAC2 expression in NK and NKT-like cells.
Conclusion: Collectively, our results show that nortriptyline might enhance GC function through modulation of HAT, HDAC2, GRβ, phospho-p38 MAPK expression. These data provide a strong rationale for combining nortriptyline with budesonide to treat COPD.
Introduction. Un siècle de « luxemburgismes »
Authors: Ducange Jean-Numa , Fondu Guillaume , Löwy Michael 
Published: April 2022

Rosa Luxemburg est une des principales représentantes du marxisme occidental. Le présent article vise à donner quelques éléments précis sur l’histoire de la réception de Rosa Luxemburg dans différents pays. Outre la France, où elle bénéficia d’une réception particulièrement remarquable, il est question dans cet article de l’appréciation de son œuvre dans les deux Allemagnes pendant la guerre froide (1949-1989), en URSS, mais aussi aux États-Unis et au Brésil. Sans prétendre à l’exhaustivité, l’article présente donc un panorama du « luxemburgisme » à l’échelle internationale.
La construction du sadomasochisme : vicissitudes de l’attachement et de la mentalisation
Authors: Chavis Douglas A. 
Published: April 2022

L’auteur de cet article intègre la recherche développementale empirique à la théorie clinique et au traitement du sadomasochisme. Trois types d’arguments illustrent la thèse selon laquelle la tendance au masochisme se développe à partir de processus relationnels qui prennent leur origine dans la dyade mère-bébé. Le premier argument se réfère à la recherche sur l’attachement et comprend des données allant de la naissance à l’âge adulte et des microanalyses filmées de dyades mère-enfant. Le second argument concerne la recherche sur la mentalisation et son rapport à l’attachement. Ces deux premières approches suggèrent qu’au fur et à mesure que les modèles d’attachement évoluent de « sécure » à « insécure » puis à « désorganisé » et que la capacité de reconnaissance de soi et de l’autre passe d’une version mentalisée à une version pré-mentalisée, ils sont progressivement corrélés à un sadomasochisme qui passe de léger à sévère. Les schèmes d’attachement insécure et désorganisé impliquent la régulation d’émotions, d’intentions et de messages contradictoires transmis à travers différentes modalités sensorielles. Ces schèmes suggèrent des manières dissociées d’être avec l’autre et de faire face à des états internes. Ils sont incorporés et organisés par le développement ultérieur. Un cas clinique, enfin, permet d’approfondir ces constructions et d’illustrer comment les connaissances émanant de la recherche sur le bébé peuvent être utilisées dans le travail avec les adultes. La discussion porte sur la relation entre les interactions mère-bébé et le sadomasochisme et la manière dont les modèles procéduraux relationnels sado-masochiques peuvent contribuer à la formation de tendances sado-masochiques au cours des différentes étapes développementales.
Le sens du réel : à propos de l’article de Winnicott. « De la communication et de la non-communication suivi d’une étude de certains contraires » ,
Authors: Ogden Thomas H. 
Published: April 2022

Dans son article « De la communication et de la non-communication suivi d’une étude de certains contraires », Winnicott avance une idée radicale : communiquer avec des objets subjectifs est une communication en cul-de-sac (une communication qui n’est adressée ni à un objet externe, ni à un objet interne) mais qui, malgré tout, dote toute expérience de la qualité d’être « éprouvée comme réelle ». Le point essentiel de son article est que « chaque individu est un élément isolé en état de non-communication permanente, toujours inconnu, jamais découvert en fait ». A ce « point essentiel », j’ajouterais un aspect que je décrirais ainsi : chaque individu a, à parts égales, besoin d’être trouvé (reconnu mais pas exposé) et besoin de ne pas être trouvé (un îlot d’incommunicado 3 ). Winnicott nous met garde. Au moment où l’analyste a atteint les couches profondes de la personnalité, l’interprétation peut introduire, de manière destructive, une part de « non-moi » trop près du noyau du self, il s’ensuit que « l’analyste ferait mieux d’attendre ». Une question sans réponse se pose alors : que fait l’analyste quand il reste silencieux ? Je réponds à cette question avec des exemples cliniques issus de ma pratique. Dans son effort de communiquer quelque chose du mystère d’exister qui est « absolument personnel », Winnicott termine son article en utilisant un langage poétique. À mon avis, Winnicott transforme la prose en poésie pour traduire quelque chose du mystère d’exister.
Comment composer un panier à paroles ? Mwà Véé . Revue culturelle kanak (1993-2000)
Authors: Bogliolo François 
Published: April 2022

Mwà Véé naît lors des Accords de Matignon : les échos socio-politiques des années 90 y résonnent et, avec l’ADCK, elle a tenu une importante place dans la création artistique calédonienne allant au-delà d’une simple présentation de la richesse linguistique et culturelle du monde kanak. Ce support apporte quelque surprenante nouveauté en matière de forme et de composition. Une esthétique revuiste se dégage à travers les premiers numéros étudiés, provenant de la tradition orale océanienne : listes, répétitions, participation du public, “voyage” cyclique de la parole, place du personnage prestigieux… Les reflets d’un syncrétisme, entre performance et musée de papier, éclairent ses feuilles. L’oralité se trahit-elle en marquant de son empreinte un écrit qui pérennise autrement ?
Efectos del desempleo femenino de larga duración en la fecundidad de las parejas españolas, 2005-2019
Authors: Grande Rafael , Del Rey Alberto , Stanek Mikolaj 
Published: April 2022

El objetivo de este trabajo es estudiar el comportamiento reproductivo de las parejas españolas convivientes en las que la mujer se encuentra en desempleo de larga duración, 24 meses o más. La hipótesis de partida plantea que esta relación está mediada por la situación socioeconómica y sociodemográfica de la familia. Por lo que, mientras en determinadas parejas el paro femenino de larga duración reduce la posibilidad de tener hijos, para otras puede constituir una oportunidad para tenerlos. Para el análisis se utilizan los microdatos de la Encuesta de Población Activa del INE durante los años 2005-2019, que abarca los periodos precrisis, crisis y postcrisis. Los resultados apuntan a la importancia de la etapa vital (edad e hijos previos), la situación laboral del cónyuge, el nivel educativo, la duración del paro de la mujer, el subsidio de desempleo y el contexto del ciclo económico como proxys de las expectativas futuras tanto en el mercado laboral como en la fecundidad.
Regard historique sur les régimes multilingues de deux organisations internationales : le Conseil de l’Europe et le Comité international de la Croix-Rouge
Authors: Garrido Sardà Maria Rosa , Sokolovska Zorana 
Published: April 2022

L’objectif de notre article est d’étudier les débats déterminant les régimes multilingues de deux organisations internationales, le Conseil de l’Europe et le Comité international de la Croix-Rouge, aux xxe et xxie siècles. À la lumière d’une perspective historique et ethnographique, nous cherchons à éclairer la conception du régime linguistique dans chaque organisation ainsi que le développement de leurs politiques linguistiques respectives.
Les ouvertures interprétatives du terme « law enforcement » dans l’espace multilingue de l’Union européenne
Authors: Bisiani Francesca 
Published: April 2022

Cet article se propose d’analyser à la fois dans un corpus multilingue de directives européennes (1991-2020), dans des dispositifs terminologiques et de traduction automatique, les écarts de signification qui se manifestent lorsque le terme « law enforcement » doit être transposé dans des systèmes juridiques et linguistiques différents. Ces observations nous permettront de faire ressortir la dimension politique de ce concept et les positionnements idéologiques des énonciateurs.
Populism as a communication phenomenon: A cross-sectional and longitudinal comparison of political campaigning on Facebook
Authors: Klinger Ulrike , Koc-Michalska Karolina 
Published: April 2022

In this paper, we adopt the notion of populism as a communication phenomenon that includes typical elements of content (i.e. people, anti-elitism, and the exclusion of out-groups) and of style (i.e. evoking fear, oversimplification, and style of language). We thus move away from actor-centric approaches towards a content-centric approach of studying populism. Empirically, our study measures populism to varying degrees and forms in 3,564 Facebook posts of political parties in France, Germany and the United Kingdom during the 2014 EU election campaigns, the 2017 national parliamentary election campaigns, and a non-electoral period in 2018 in each country. The results show that populism is not a marginal phenomenon but that it is present in about one-fourth of all posts in some form; that there is variance between countries, party types, policy fields, and over time. While radical parties are very exclusionary towards out-groups on the right and very anti-elitist on the left and the right, this observation provides only a partial view of the multifaceted phenomenon of populism.
Expressions intertextuelles et analyses transculturelles dans Les Aventures d’Arsène Lupin de Maurice Leblanc
Authors: Hannedouche Cédric 
Published: April 2022

En 1905, Maurice Leblanc (1864-1941) gagne le cœur du public en léguant à la postérité littéraire la figure d’un illustre gentleman cambrioleur. Arsène Lupin, « l’homme aux mille visages » trompe incessamment son monde, se cachant même aux yeux du lecteur qui scrute chaque indice afin de démasquer l’identité derrière laquelle se dissimule l’énergique héros. Le mécanisme, bien connu depuis, de l’usurpation d’identité ne reflèterait-il pas au fond une démarche auctoriale ? Il convient ici de rappeler que Maurice Leblanc a passé sa première vie d’écrivain à tenter le succès par d’incessantes publications de romans, contes et nouvelles d’inspiration réaliste sur le modèle de son maître Maupassant. L’échec est cuisant. Les Belles-Lettres refusent d’accueillir l’auteur normand. Maurice Leblanc ne s’avoue pas vaincu pour autant et irrigue, comme bien d’autres, ses succès populaires d’une forte intertextualité issue d’une littérature légitimée par le canon et les anthologies scolaires.
Neutrophil Protein Kinase R Mediates Endothelial Adhesion and Migration by the Promotion of Neutrophil Actin Polymerization
Authors: Inoue Reiko , Nishi Hiroshi , Osaka Mizuko , Yoshida Masayuki , Nangaku Masaomi 
Published: April 2022

Abstract
Neutrophils protect against bacterial and fungal infections, but tight regulation of cell activation is essential for avoiding tissue damage in autoimmune disorders. Protein kinase R (PKR) is a serine/threonine kinase originally characterized by its role in the defense mechanisms against viral infection. Although PKR is involved in the signaling pathways of neurodegenerative diseases and metabolic disorders, its function in neutrophils is not well delineated. In this study, we demonstrate that human neutrophil PKR mediates adhesion to endothelial cells under physiological flow conditions but does not mediate rolling on those cells. Also, neutrophil PKR activation contributes to migration toward chemoattractants. Mechanistically, neutrophil PKR mediates the cell spreading and binding to ICAM-1 in static condition. Moreover, Ab microarray reveals that calcium/calmodulin-dependent protein kinase II is phosphorylated downstream of PKR and affects actin polymerization that is a cytoskeleton rearrangement indispensable for neutrophil migration induced by fMLF. In vivo, neutrophil recruitment into the dorsal air pouch of mice is reduced by PKR inhibitor treatment. Also, in mice with nephrotoxic serum nephritis, the compound treatment suppresses neutrophil accumulation in kidney glomerulus and subsequent development of albuminuria. Thus, in vascular inflammation, neutrophil PKR plays a critical role in the recruitment process, including endothelial adhesion and migration via leukocyte actin polymerization.
Psychometric properties of Kessler's Psychological Distress Scale (K10) in cancer patients
Authors: Thakre Manish Namdeo , Sathe Harshal Shriram , Talapalliwar Manoj Rajanna 
Published: April 2022

Context:
Kessler's Psychological Distress Scale (K10) is a self-rated, easy-to-apply scale to measure psychological distress. The suitability of its use in treatment-seeking cancer patients in the clinical setup has not been studied.

Aims:
The aim was to assess the psychometric properties and associations of K10 with sociodemographic and clinical variables and depression levels in the cancer patients visiting the hospital.

Settings and Design:
The research was a cross-sectional, observational, descriptive study conducted in the oncology outpatient department of a public hospital.

Materials and Methods:
The data were collected from 155 cancer patients using semi-structured pro forma for sociodemographic and illness-related information. K10 and Patient Health Questionnaire-9 were used to quantify psychological distress and depression.

Statistical Analysis Used:
The factor structure of Kessler's 10-item scale was assessed by confirmatory factor analysis, and Cronbach's alpha was calculated as a measure of internal consistency. Given the nonnormal distribution of quantitative data, nonparametric tests were used to analyze the association of K10 scores with sociodemographic and clinical variables and depression scores.

Results:
The K10 showed good internal consistency (Cronbach's alpha = 0.914) in the cancer patients. In confirmatory factor analysis using structural equation modeling, the single-factor and two-factor models could not adequately fit across goodness-of-fit indices. There was a significant association between the levels of psychological distress and depression in cancer patients.

Conclusion:
K10, in its current form, is a reliable instrument to measure psychological distress. However, a need-based modification of the existing scale is required in treatment-seeking cancer patients.
Correlation of factors associated with marital satisfaction-A cross-sectional study from an urban place in Andhra Pradesh
Authors: Goud Sripathi Santhosh , Swayntika Adavi , Indla Vishal , Kolli Naga Saritha 
Published: April 2022

Context:
Marriage is an age-old tradition that has become an essential custom for the survival and evolution of human beings. Marital satisfaction is the most essential aspect of a marriage. It is an important psychological construct affecting individual and relational well-being. Multiple factors affect marital satisfaction, and research related to these factors is scarce in India.

Aims:
We aimed to study the association between various sociodemographic factors, attachment styles, sexual satisfaction, and marital satisfaction.

Materials and Methods:
It was a cross-sectional, correlational study done on 80 subjects who were selected by purposive sampling method. A semi-structured pro forma was used to collect sociodemographic data. ENRICH (Evaluation and Nurturing Relationship Issues, Communication, and Happiness Marital Satisfaction scale was used to assess marital satisfaction. Index of Sexual Satisfaction was used for rating sexual satisfaction. A relationship questionnaire was used to measure the adult attachment style. Descriptive and inferential statistical analyses were done to find the relation between different study variables.

Results:
Among sociodemographic variables, gender (P = 0.03), ongoing conflicts (P < 0.001), and the attachment style of the subjects (P < 0.001) had shown a statistically significant relationship with marital satisfaction. Problems in the area of sexual satisfaction had a negative correlation with marital satisfaction (r = −663, P < 0.001).

Conclusions:
Although marital satisfaction is culturally dependent, attachment styles, ongoing conflicts in one's relationship, and sexual satisfaction are some of the common factors associated with marital satisfaction across cultures.