bluuebunny/crossref_metadata_2025_split huggingface dataset:
Emotion‐related impulsivity and rumination: Unique and conjoint effects on suicidal ideation, suicide attempts, and nonsuicidal self‐injury across two samples
Authors: Johnson Sheri L. , Robison Morgan , Anvar Sarah , Swerdlow Benjamin A. , Timpano Kiara R. 
Published: March 2022

AbstractIntroductionRumination and emotion‐related impulsivity predict suicidal ideation, suicide attempts, and nonsuicidal self‐injury (NSSI). Because rumination and emotion‐related impulsivity, though, are highly correlated, we consider their unique vs. conjoint influence on suicidal ideation and self‐harm.MethodAcross two samples of adults (N’s = 171 and 191), we examined how rumination and emotion‐related impulsivity relate to suicidal ideation, suicide attempts, and NSSI. We assess the more general process of repetitive negative thinking and the more specific process of suicide‐related rumination. Participants completed the Three‐Factor Impulsivity Index and the self‐report Columbia‐Suicide Severity Rating Scale. Those in sample 1 completed the Perseverative Thinking Questionnaire and the Deliberate Self‐Harm Inventory, and those in Sample 2 completed the Suicide Rumination Scale.ResultsEmotion‐related impulsivity and both forms of rumination showed robust bivariate correlations with suicidal ideation, suicide attempts, and NSSI. Neither rumination or impulsivity related to suicide attempts controlling for ideation or to NSSI. In multivariable analyses, emotion‐related impulsivity but not general rumination was tied to suicidal ideation. In contrast, suicide‐related rumination was more directly tied to suicidal ideation than was impulsivity.ConclusionsFindings provide support for a more nuanced approach to the forms of impulsivity and rumination related to suicidal ideation.
Adolescent normative beliefs about aggression mediate the association between fathers’ psychological control in adolescence and physical aggression in emerging adulthood
Authors: Choe So Young , Lee Jungeun Olivia , Read Stephen J. 
Published: March 2022

AbstractWe examined whether adolescent normative beliefs about aggression (NBA) functioned as a mechanism through which parental psychological control (PPC) predicted physical aggression in emerging adulthood via secondary data analyses with the Child Development Project longitudinal data. Fathers’ psychological control (fPC) that adolescents reported at age 13 predicted NBA at age 16, which then predicted their aggression at age 18, after controlling for harsh parenting, earlier NBA, aggression, and SES at age 13 and adolescent gender. However, mothers’ psychological control (mPC) that adolescents perceived at age 13 did not predict NBA at age 16. Our results suggest that fPC at age 13 uniquely predicts NBA at age 16, and that adolescents are able to distinguish fPC from mPC. Moreover, no differences in the mediational paths were found based on the gender of the adolescents, emphasizing the detrimental impacts of PPC regardless of the gender of the adolescents. Our findings suggest that adolescents may receive the message from their psychologically controlling fathers that it is okay to hurt others for one's own gain, and then the resulting belief that aggression is appropriate predicts their physical aggression in their emerging adulthood.
Experimental Study on Local Damage to Reinforced Concrete Panels Subjected to Oblique Impact by Projectiles
Authors: Okuda Yukihiko , Nishida Akemi , Kang Zuoyi , Tsubota Haruji , Li Yinsheng 
Published: March 2022

Abstract
Most empirical formulas used to evaluate local damage to reinforced concrete (RC) structures have been based on impact tests conducted with a rigid projectile at an impact angle normal to the target structure. Only a few impact tests have been performed involving a soft projectile. Therefore, in this study, we conducted a series of impact tests to evaluate the local damage to RC panels subjected to normal and oblique impacts by rigid and soft projectiles. This paper presents the test conditions, test equipment, test results, and obtained knowledge on local damage to RC panels subjected to normal and oblique impacts.
Temporal and Spatial Trends From Counterfactual Scenarios of Physical Activity on Mortality, Years of Life Lost, and Life Expectancy Due to Noncommunicable Diseases in Argentina
Authors: García-Witulski Christian 
Published: March 2022

Background: This study estimates the spatial distribution and trends in preventable deaths, years of life lost (YLL), and life expectancy (LE), associated with noncommunicable diseases under alternative distributions of physical activity in Argentina. Methods: Potential impact fractions were used to calculate the preventable deaths and YLL attributable to various scenarios of physical activity. Cause-eliminated life tables were used to estimate LE gains, and Monte Carlo simulations were performed for uncertainty analysis. Results: From 2005 to 2018, physical activity could have prevented up to 7544 to 8220 potential deaths (≈4.27% of major noncommunicable diseases and ≈2.66% of all causes) and about 221 to 219 YLL per 100,000 inhabitants; between 0.67 and 0.71 years of LE could have been gained. If the World Health Organization recommendations (at least 600 metabolic equivalent tasks minutes per week) had been achieved, between 2813 and 3111 potential deaths could have been prevented, about 80 fewer years of life (per 100,000 inhabitants) would have been lost, and 0.23 years of LE could have been gained. A 15% reduction in insufficient physical activity has shown a small impact on outcomes. Conclusion: Public health initiatives aimed at increasing population-wide physical activity could reduce noncommunicable disease deaths in Argentina.
Quantifying large-scale continental shelf margin growth and dynamics across middle-Cretaceous Arctic Alaska with detrital zircon U-Pb dating
Authors: Lease Richard O. , Houseknecht David W. , Kylander-Clark Andrew R.C. 
Published: March 2022

Abstract
Sequence stratigraphy provides a unifying framework for integrating diverse observations to interpret sedimentary basin evolution; however, key time assumptions about stratigraphic elements spanning hundreds of kilometers are rarely quantified. We integrate new detrital zircon U-Pb (DZ) dates from 28 samples with seismic mapping to establish a chronostratigraphic framework across 800 km and ~20 m.y. for the middle-Cretaceous Torok-Nanushuk clinothem of Arctic Alaska (USA). Shelf-margin DZ dates indicate continent-scale sediment routing with Russian Chukotka provenance and provide reliable maximum depositional ages derived from arc volcanism. Shelf-margin advance rates display a clear relationship to toplap trajectories and provide empirical support for long-held inferences linking sediment supply to margin architecture. Two distinct shelf-margin growth regimes are evident: (1) a ca. 115–107 Ma phase of rapid ~50 km/m.y. shelf advance rates with mainly progradational trajectories; and (2) a ca. 107–98 Ma phase of moderate ~13 km/m.y. shelf advance rates with progradational-retrogradational-aggradational trajectories. We established a subsequent shelf–to–deep water correlation by independently dating ca. 98–95 Ma low shelf accommodation and basin-floor deposition as far as 240 km east that indicate lowstand shedding and a change to localized routing with Brooks Range provenance. Finally, we dated a ca. 95 Ma basin-wide transgression at deep-water to shelfal settings across 350 km that exhibits apparent synchroneity consistent with an event-significant surface. In one of the world's largest foreland-basin clinothems, our work constrains the timing and duration of key depositional elements to test large-scale sequence stratigraphic assumptions, enables reliable correlation and quantification of sediment dynamics across 800 km, and captures the chronology of a giant regressive-transgressive cycle.
Calcite U-Pb ages constrain petroleum migration pathways in tectonic complex basins
Authors: Cong Fuyun , Tian Jinqiang , Hao Fang , Kylander-Clark Andrew R.C. , Pan Wenqing , Zhang Baoshou 
Published: March 2022

Abstract
Tracing secondary oil migration pathways is critical for understanding petroleum system evolution histories. Traditional tools (e.g., molecular indicators and numerical modeling) utilized for evaluating oil migration processes either lead to ambiguous interpretations or only provide qualitative estimates. We quantitatively constrain secondary oil migration processes under an absolute time frame by integrating oil-inclusion fluorescence and in situ calcite U-Pb dating on calcite veins and cements hosting primary oil inclusions. Fluorescence spectra of oil inclusions and U-Pb ages were obtained on samples from ultra-deep Ordovician reservoirs along two major faults in the Halahatang oilfield, Tarim Basin (northwestern China). Absolute U-Pb ages suggest two main oil charge events during 475–433 Ma and 294–262 Ma, respectively, and revealed a northward-decreasing trend for oil maturity during single charge events. Vertical migration of oil from in situ source rock through active (or reactivated) faults is believed to be the key process inducing the spatial maturity variation in charged oils and considered as the main mechanism of secondary migration, with brecciated fault zones and dilatant fractures along faults acting as major vertical oil-migration pathways. The successful application of this approach has wider implications for elucidating petroleum migration processes in tectonic complex basins worldwide.
A Tonian volcano-sedimentary succession in Newfoundland, eastern North America: A post-Grenvillian link to the Asgard Sea?
Authors: Strowbridge Susan , Indares Aphrodite , Dunning Greg , Wälle Markus 
Published: March 2022

Abstract
Early Tonian bimodal volcanic and sedimentary rocks (the Pine Pond succession) were identified in the Appalachians of eastern Laurentia for the first time, with U-Pb ages of igneous zircon at 951.4 ± 9 Ma for a felsic tuff and 952 ± 10 Ma for a crosscutting granite sheet. This Neoproterozoic succession is part of the East Pond metamorphic suite on the Baie Verte Peninsula (Newfoundland, Canada), which also contains 1491 Ma orthogneiss and is consistent with deposition over Mesoproterozoic basement in a pre-Iapetan extensional setting. Collectively, the data suggest a correlation with the southern Labrador Pinware terrane of the Grenville Province, where 1.52–1.46 Ga bedrock is intruded by 975–950 Ma granite. In addition, the age and location of this 952 Ma succession are consistent with deposition on the western margin of the Asgard Sea. Thus, the Pine Pond succession provides a link between key events in the assembly of the supercontinent Rodinia: the end of the Grenville orogeny, which led to the amalgamation of Laurentia and Amazonia, and the early Neoproterozoic evolution of the Asgard Sea, which separated Laurentia and Baltica.
Effects of ACE inhibitors and angiotensin receptor blockers: protocol for a UK cohort study using routinely collected electronic health records with validation against the ONTARGET trial
Authors: Baptiste Paris J , Wong Angel Y S , Schultze Anna , Cunnington Marianne , Mann Johannes F E , Clase Catherine , Leyrat Clémence , Tomlinson Laurie A , Wing Kevin 
Published: March 2022

IntroductionCardiovascular disease is a leading cause of death globally, responsible for nearly 18 million deaths worldwide in 2017. Medications to reduce the risk of cardiovascular events are prescribed based on evidence from clinical trials which explore treatment effects in an indicated sample of the general population. However, these results may not be fully generalisable because of trial eligibility criteria that generally restrict to younger patients with fewer comorbidities. Therefore, evidence of effectiveness of medications for groups underrepresented in clinical trials such as those aged ≥75 years, from ethnic minority backgrounds or with low kidney function may be limited.Using individual anonymised data from the Ongoing Telmisartan Alone and the Ramipril Global Endpoint Trial (ONTARGET) trial, in collaboration with the original trial investigators, we aim to investigate clinical trial replicability within a real-world setting in the area of cardiovascular disease. If the original trial results are replicable, we will estimate treatment effects and risk in groups underrepresented and excluded from the original clinical trial.Methods and analysisWe will develop a cohort analogous to the ONTARGET trial within the Clinical Practice Research Datalink between 1 January 2001 and 31 July 2019 using the trial eligibility criteria and propensity score matching. The primary outcome is a composite of cardiovascular death, non-fatal myocardial infarction, non-fatal stroke and hospitalisation for congestive heart failure. If results from the cohort study fall within pre-specified limits, we will expand the cohort to include under represented and excluded groups.Ethics and disseminationEthical approval has been granted by the London School of Hygiene & Tropical Medicine Ethics Committee (Ref: 22658). The study has been approved by the Independent Scientific Advisory Committee of the UK Medicines and Healthcare Products Regulatory Agency (protocol no. 20_012). Access to the individual patient data from the ONTARGET trial was obtained by the trial investigators. Findings will be submitted to peer-reviewed journals and presented at conferences.
Music-based interventions to address well-being in people with a vision impairment: protocol for a scoping review
Authors: Somani Nurbanu , Beukes Eldre , Street Alexander , Lindsay Rosie , Allen Peter M 
Published: March 2022

IntroductionMusic-based interventions are used to improve well-being in individuals who are psychologically vulnerable and have long-term illnesses. To date, no study has systematically assessed the literature on music-based interventions aimed at improving well-being in people who have a vision impairment (VI). The purpose of the current protocol is to provide the methodology for a scoping review, to explore the therapeutic outcomes and strategies used in music-based interventions aimed specifically at people with a VI.Methods and analysisThis scoping review protocol was developed according to the Joanna Briggs Institute methodology and reporting will follow the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping Reviews checklist and guidelines. The anticipated start date for this study was July 2021. The proposed review will include studies that use music therapeutically as part of a treatment intervention for all VI populations. Studies that meet the inclusion criteria with regards to population, concept and context will be included. Electronic database searches will be conducted independently by two researchers and include MEDLINE, EMBASE, CINAHL Plus, PsycINFO and Web of Science. Further searches will include the reference lists of included studies and grey literature. A narrative synthesis will be conducted to map out the types of therapeutic music interventions undertaken and to compare therapeutic outcomes.Ethics and disseminationAs the methodology of this study consists of collecting data from publicly available articles, it does not require ethics approval. The findings of the planned scoping review are important to guide the development of future interventions, or strategies, that will attempt to use music to improve well-being in people with a VI. The results will be disseminated through a peer-reviewed publication and conference presentations.
Thermal kinetics, thermodynamics, decomposition mechanism, and thermal safety performance of typical ammonium perchlorate-based molecular perovskite energetic materials
Authors: An Erhai , Chen Shaoli , Li Xiaoxia , Tan Yingxin , Cao Xiong , Deng Peng 
Published: March 2022

In this work, we report the thermal kinetics, thermodynamics, and decomposition mechanism of AP-based molecular perovskite energetic materials and estimate their thermal safety performance. Typical AP-based molecular perovskite energetic materials, (H2dabco)[NH4(ClO4)3] (DAP-4), (H2pz)[NH4(ClO4)3](PAP-4), (H2mpz)[NH4(ClO4)3](PAP-M4), and (H2hpz)[NH4(ClO4)3] (PAP-H4), were synthesized and characterized. These were studied using differential scanning calorimetry (DSC). The results show that all of the obtained AP-based molecular perovskite energetic materials have higher thermal decomposition temperatures, and the peak temperatures are more than 360 °C. All follow random nucleation and growth models. Other thermodynamic parameters, such as the reaction enthalpy (ΔH), entropy change (ΔS), and Gibbs free energy (ΔG), show that they are generally thermodynamically stable. Moreover, their adiabatic induced temperatures were obtained; TD24 of DAP-4, PAP-4, PAP-M4, and PAP-H4 were 246.6, 201.2, 194.5, and 217.5 °C, respectively. This study offers an important and in-depth understanding of the thermal decomposition characteristics of AP-based molecular perovskite energetic materials and their potential applications.
Abstract ES5-3: Management of special subtypes of TNBC
Authors: Thomas A 
Published: March 2022

Abstract
Less common subtypes of triple-negative breast cancer encompass a heterogeneous group of cancers some of which are rare and others which are ultra-rare. Given the high prevalence of breast cancer, less common TNBC subtypes can be encountered with some frequency in clinical practice. These subtypes, which include, metaplastic, medullary, apocrine, mucoepidermoid, secretory, and adenoid cystic breast cancer, have diverse histologies, molecular profiles, and prognoses. This educational discussion will review the distinct features of less common triple-negative breast cancers and will address how these impact current, as well as possible future, management strategies. Possible clinical trial approaches to further understand and better treat special subtypes of TNBC will also be discussed.
Citation Format: A Thomas. Management of special subtypes of TNBC [abstract]. In: Proceedings of the 2021 San Antonio Breast Cancer Symposium; 2021 Dec 7-10; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2022;82(4 Suppl):Abstract nr ES5-3.
Abstract P1-02-15: Predicting molecular subtypes of breast cancer using
Authors: Huang Chi-Cheng , Phan Nam Nhut , Tseng Ling-Ming 
Published: March 2022

Abstract
Purpose: Breast cancer is a heterogeneously complex disease. A number of molecular subtypes with distinct biological features lead to different treatment responses and clinical outcomes. Traditionally, breast cancer is classified into subtypes based on gene expression profiles; these subtypes, namely intrinsic subtypes, include luminal A, luminal B, basal-like and HER2-enriched breast cancer. This molecular taxonomy, however, could only be appraised through transcriptome analyses. We aim to classify breast cancer intrinsic subtypes using un-annotated approach using deep learning models.Methods: 388 pathological whole slide images (WSIs) from TCGA-BRCA dataset were downloaded from TCGA-GDC portal. These WSIs underwent patches generation and normalization using PyHIST tool and Macenko algorithm, respectively. Laplacian algorithm was applied to remove patches with blurry areas and pixelated. The remaining patches (n = 1,833,889) were divided into 3 parts for training (70%), testing (5%) and validation (25%). We applied a 2-step transfer learning with 2 pre-trained models, namely ResNet50, ResNet101, Xception and VGG16, which have been trained on another in-house breast cancer pathological image dataset. Results: these four models shown promising classification results of 4 breast cancer intrinsic subtypes with accuracy ranged from 0.68 (ResNet50 model) to 0.78 (ResNet101 model) in both testing and validation sets. The average AUC score for these models were from 0.88 (ResNet50 model) to 0.94 (ResNet101 model), whereas ResNet101_imgnet with “imagenet” weight archived an accuracy of 0.73 and AUC of 0.92. The overall accuracy of patient-wise prediction even shown a higher average accuracy of 0.914. These models’ prediction visualization was also used to demonstrate that the process of model learning was based on pathological cells’ clusters. Conclusion: Our study demonstrated the feasibility and capability of the deep learning model in classifying breast cancer intrinsic subtypes without region of interest annotation, which wound facilitate the clinical applicability of proposed models.
Citation Format: Chi-Cheng Huang, Nam Nhut Phan, Ling-Ming Tseng. Predicting molecular subtypes of breast cancer using [abstract]. In: Proceedings of the 2021 San Antonio Breast Cancer Symposium; 2021 Dec 7-10; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2022;82(4 Suppl):Abstract nr P1-02-15.
Abstract P1-06-08: Metabolic diversity determines metastatic fitness of breast cancer brain-tropic cells
Authors: Malladi Srinivas 
Published: March 2022

Abstract
HER2+ breast cancer patients presenting with either synchronous (S-BM), latent residual (Lat) or metachronous (M-BM) brain metastases have poor survival outcomes. However, the basis for disparate metastatic fitness among disseminated tumor cells of similar oncotype within a distal organ remains unknown. Employing isogenic HER2+ breast cancer brain metastasis models, we show metabolic diversity and plasticity within brain-tropic cells determines metastatic fitness. Lactate secreted by aggressive metastatic cells (S-BM and M-BM) or lactate supplementation to mice bearing latent residual disease limits innate immune surveillance and triggers overt metastasis. Attenuating lactate metabolism in S-BM impedes metastasis, while M-BM adapt and survive as latent residual disease. In contrast to S-BM, Lat and M-BM survive in equilibrium with innate immune surveillance, oxidize glutamine and maintain cellular redox homeostasis through the anionic amino acid transporter xCT. Moreover, xCT expression is significantly higher in matched metachronous brain metastatic samples compared to primary tumors from HER2+ breast cancer patients. Genetic or pharmacological blockade of xCT eradicates residual disease and brain metastatic relapse in these preclinical models.
Citation Format: Srinivas Malladi. Metabolic diversity determines metastatic fitness of breast cancer brain-tropic cells [abstract]. In: Proceedings of the 2021 San Antonio Breast Cancer Symposium; 2021 Dec 7-10; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2022;82(4 Suppl):Abstract nr P1-06-08.