bluuebunny/crossref_metadata_2025_split huggingface dataset:
SCOPE: safer care for older persons (in residential) environments—a pilot study to enhance care aide-led quality improvement in nursing homes
Authors: Doupe Malcolm , Brunkert Thekla , Wagg Adrian , Ginsburg Liane , Norton Peter , Berta Whitney , Knopp-Sihota Jennifer , Estabrooks Carole 
Published: February 2022

Abstract
Background
Nursing home residents require daily support. While care aides provide most of this support they are rarely empowered to lead quality improvement (QI) initiatives. Researchers have shown that care aide-led teams can successfully participate in a QI intervention called Safer Care for Older Persons in Residential Care Environments (SCOPE). In preparation for a large-scale study, we conducted a 1-year pilot to evaluate how well coaching strategies helped teams to enact this intervention. Secondarily, we measured if improvements in team cohesion and communication, and resident quality of care, occurred.

Methods
This study was conducted using a prospective single-arm study design, on 7 nursing homes in Winnipeg Manitoba belonging to the Translating Research in Elder Care research program. One QI team was selected per site, led by care aides who partnered with other front-line staff. Each team received facilitated coaching to enact SCOPE during three learning sessions, and additional support from quality advisors between these sessions. Researchers developed a rubric to evaluate how well teams enacted their interventions (i.e., created actionable aim statements, implemented interventions using plan-do-study-act cycles, and used measurement to guide decision-making). Team cohesion and communication were measured using surveys, and changes in unit-level quality indicators were measured using Resident Assessment Instrument-Minimum Data Set data.

Results
Most teams successfully enacted their interventions. Five of 7 teams created adequate-to-excellent aim statements. While 6 of 7 teams successfully implemented plan-do-study-act cycles, only 2 reported spreading their change ideas to other residents and staff on their unit. Three of 7 teams explicitly stated how measurement was used to guide intervention decisions. Teams scored high in cohesion and communication at baseline, and hence improved minimally. Indicators of resident quality care improved in 4 nursing home units; teams at 3 of these sites were scored as ‘excellent’ in two or more enactment areas, versus 1 of the 3 remaining teams.

Conclusions
Our coaching strategies helped most care aide-led teams to enact SCOPE. Coaching modifications are needed to help teams more effectively use measurement. Refinements to our evaluation rubric are also recommended.
Using ELECTRE-TRI and FlowSort methods in a stock portfolio selection context
Authors: Emamat Mir Seyed Mohammad Mohsen , Mota Caroline Maria de Miranda , Mehregan Mohammad Reza , Sadeghi Moghadam Mohammad Reza , Nemery Philippe 
Published: February 2022

AbstractIn recent years, multi-criteria sorting problems have become an interesting topic for researchers working on multi-criteria decision-making. ELimination and Choice Expressing REality (ELECTRE)-TRI and FlowSort are well-known approaches suggested for such a classification. The current study aimed to implement ELECTRE-TRI and FlowSort methods in the stock portfolio selection (SPS) as one of the most popular and important decision-making subjects and compare the outcomes of each method to understand how these methods perform in SPS problems. In this study, the best–worst method was applied to determine the weights of criteria. Four approaches for ELECTRE-TRI and 15 approaches for FlowSort were considered. Finally, 19 different approaches were considered to select stocks from a large pool of stocks. Results indicated that the model parameter should be properly defined to minimize inconsistencies and improve the power of the model.
Venogenic erectile dysfunction: diagnosis on computed tomography cavernosography and endovascular treatment using an anterograde access via deep dorsal penile vein
Authors: Hoppe Hanno , Diehm Nicolas 
Published: February 2022

Abstract
Background
The underlying etiologies of erectile dysfunction may be manifold. Among them, vasculogenic etiologies are of increasing relevance and are not strictly limited to the elderly population. According to recent study, venogenic erectile dysfunction appears to be even more relevant than arteriogenic erectile dysfunction. Venogenic erectile dysfunction due to venous leakage causes insufficient penile blood retention. Proper diagnosis of venous leakage should include both color Doppler flow analysis and computed tomography cavernosography for adequate patient selection and treatment planning. Besides surgical ligation of penile draining veins, endovascular treatment methods may demonstrate more promising results. Especially endovascular embolization of venous leakage using an anterograde access via deep dorsal penile veins appears to be more beneficial for patients’ clinical outcome and awareness of this technique should be raised among endovascular interventionalists.

Case presentation
A 47-year-old man was diagnosed with venogenic erectile dysfunction due to venous leakage on color Doppler flow analysis and computed tomography cavernosography. He did not respond to PDE-5-inhibitors. This patient demonstrated major venous leakage of paired deep dorsal penile veins via periprostatic veins and internal pudendal veins draining into both iliohypogastric veins. This patient’s venous leak was treated with endovascular embolization using an anterograde access via deep dorsal penile veins.

Conclusion
This patient’s erectile dysfunction due to venous leakage, based on findings in color Doppler flow analysis and computed tomography cavernosography, was embolized using an anterograde access via deep dorsal penile veins as a minimally-invasive endovascular treatment option.
Antisense oligonucleotides: recent progress in the treatment of various diseases
Authors: Gopi Chandravadivelu , Dhanaraju Magharla Dasaratha , Dhanaraju Kavitha 
Published: February 2022

Abstract
Background
Antisense oligonucleotides are a promising novel class of therapeutic agents to treat different diseases in living things. They provide an efficient method for making target-selective agents because they change gene expression sequences. Therefore, the malfunctioning protein could be stopped, and the source of disease would be obliterated. The existing reviews of antisense oligonucleotides are focusing on discovery, development and concept. However, there is no review paper concerning the latest development of antisense oligonucleotides and their different therapeutic uses. Therefore, the present work has been targeting a comprehensive summary of newly synthesized antisense oligonucleotides and their biological activities.

Main body
Antisense oligonucleotides are different from traditional therapeutic agents that are planned to interact with mRNA and modulate protein expression through a unique mechanism of action. In the last three decades, several researchers revealed the newer antisense oligonucleotides found with a high therapeutic profile due to more selective action on the drug target and thus producing a lesser side effect and low toxicity. This review emphasizes the research work on antisense oligonucleotides and their therapeutic activities.

Short conclusion
With the support of the literature review, here we enlisted various antisense oligonucleotides that were prepared by appropriate technique and explored their pharmacological activities. To the best of our knowledge, it is the right time to consider the antisense oligonucleotides as a perfect choice of treatment for different diseases due to conceptual simplicity, more selective action, lesser side effects, low toxicity and permanent cure.

Graphical abstract
Effects of multivitamin, mineral and n-3 polyunsaturated fatty acid supplementation on aggression among long-stay psychiatric in-patients: randomised clinical trial
Authors: de Bles Nienke J. , Rius-Ottenheim Nathaly , Geleijnse Johanna M. , van de Rest Ondine , Bogers Jan P.A.M. , Schat Anke , Nijman Henk L.I. , van den Berg David , Joos Lucas , van Strater Annelies , de Ridder Tine , Stolker Joost J. , van den Hout Wilbert B. , van Hemert Albert M. , Giltay Erik J. 
Published: February 2022

BackgroundAggression and violent incidents are a major concern in psychiatric in-patient care. Nutritional supplementation has been found to reduce aggressive incidents and rule violations in forensic populations and children with behavioural problems.AimsTo assess whether multivitamin, mineral and n-3 polyunsaturated fatty acid supplementation would reduce the number of aggressive incidents among long-stay psychiatric in-patients.MethodThe trial was a pragmatic, multicentre, randomised, double-blind placebo-controlled study. Data were collected from 25 July 2016 to 29 October 2019, at eight local sites for mental healthcare in The Netherlands and Belgium. Participants were randomised (1:1) to receive 6-month treatment with either three supplements containing multivitamins, minerals and n-3 polyunsaturated fatty acid, or placebo. The primary outcome was the number of aggressive incidents, determined by the Staff Observation Aggression Scale – Revised (SOAS-R). Secondary outcomes were patient quality of life, affective symptoms and adverse events.ResultsIn total, 176 participants were randomised (supplements, n = 87; placebo, n = 89). Participants were on average 49.3 years old (s.d. 14.5) and 64.2% were male. Most patients had a psychotic disorder (60.8%). The primary outcome of SOAS-R incidents was similar in supplement (1.03 incidents per month, 95% CI 0.74–1.37) and placebo groups (0.90 incidents per month, 95% CI 0.65–1.19), with a rate ratio of 1.08 (95% CI 0.67–1.74, P = 0.75). Differential effects were not found in sensitivity analyses on the SOAS-R or on secondary outcomes.ConclusionsSix months of nutritional supplementation did not reduce aggressive incidents among long-stay psychiatric in-patients.
Regulation of Wnt distribution and function by Drosophila glypicans
Authors: Waghmare Indrayani , Page-McCaw Andrea 
Published: February 2022

ABSTRACT
The extracellular distribution of secreted Wnt proteins is crucial for their ability to induce a response in target cells at short and long ranges to ensure proper development. Wnt proteins are evolutionarily conserved ligands that are lipid-modified, and their hydrophobic nature interferes with their solubility in the hydrophilic extracellular environment. This raises the question of how Wnt proteins spread extracellularly despite their lipid modifications, which are essential for both their secretion and function. Seminal studies on Drosophila Wingless (Wg), a prototypical Wnt, have discovered multiple mechanisms by which Wnt proteins spread. A central theme emerges from these studies: the Wnt lipid moiety is shielded from the aqueous environment, allowing the ligands to spread and remain viable for signaling. Wnt distribution in vivo is primarily facilitated by glypicans, which are cell-surface heparan sulfate proteoglycans, and recent studies have further provided mechanistic insight into how glypicans facilitate Wnt distribution. In this Review, we discuss the many diverse mechanisms of Wnt distribution, with a particular focus on glypican-mediated mechanisms.
Stopped-flow-optical Absorption and -ESR Detection of Rutin (Quercetin-3-O-rutinoside) B-ring Catechol Aroxyl Radicals Generated during Redox Reaction between Rutin and O2−• Radical in DMSO
Authors: Kuwabara Keiko , Nishio Natsuki , Nakano Ryota , Sakurai Yasuhiro , Yamaguchi Tomoko , Miyake Yusuke , Kanaori Kenji , Tajima Kunihiko 
Published: February 2022

Abstract
Stopped-flow-optical absorption and -electron spin resonance spectroscopies were employed to analyze the kinetic behaviors of short-lived intermediate radicals in redox reactions between electrochemically generated O2−• radicals and rutin (Rut(OH)2) in DMSO. The results of both studies indicate the formation of a rutin B-ring catechol-derived aroxyl (Rut(OH)O•) radical in the presence of excess amounts of rutin.
Validation of a lithium-ion commercial battery pack model using experimental data for stationary energy management application
Authors: Foles Ana , Fialho Luís , Horta Pedro , Collares-Pereira Manuel 
Published: February 2022

Background:A cost-effective solution for the design of distributed energy storage systems implies the development of battery performance models yielding a suitable representation of its dynamic behaviour under realistic operation conditions.Methods:In this work, a lithium-ion battery (LIB) is tested to be further modelled and integrated into an existing energy management control system. This specific LIB (5.0 kW /9.8 kWh) is integrated with a commercial inverter and solar photovoltaic (PV) system (3.3 kWp) as part of a microgrid that is also encompassing other storage technologies at the University of Évora, Pole of INIESC – National Research Infrastructure for Solar Energy Concentration. The battery and the inverter are fully characterized through the implementation of a testing protocol aiming at better describing the battery performance. Then, a battery model is built upon both the existent LIB description and experimental fitting regression, for real-time predictive optimization control development. Considering the pre-determined efficiency of the inverter, the model allows to obtain the voltage curve, the series resistance (i.e., to describe instantaneous voltage drop/rise and transients), and the state of charge (SOC) and/or energy capacity, based on the current input. The developed model is validated through the comparison with the experimental results.Results:In discharge state, the model approach presented a higher voltage RMSE (root mean square error) of 5.51 V and an MRE (maximum relative error) of 5.68 %. Regarding SOC the MRE obtained was approximately 6.82 %. In charge state, the highest RMSE voltage was 5.27 V, with an MRE of 6.74 %. Concerning SOC, the MRE obtained was approximately 6.53 %. Conclusions:The developed setup allowed us to perform the necessary characterization tests under real operating conditions. Based on computational effort, simplicity of use, and the associated model error compared with the experimental data, generally, the model describes the battery behaviour.
A comparative analysis of the sense of optimism and life satisfaction among judo and brasilian jiu jitsu fighters
Authors: Rawat Kanupriya , Pujszo Ryszard , Wojdat Marta , Zając Magdalena 
Published: February 2022

Background and Study Aim

The main aim of the study was to determine the level of optimism and life satisfaction among men of different ages who professionally or recreationally practice judo and Brazilian jiu-jitsu.

Material and Methods

The study involved 43 judo athletes, 43 Brazilian jiu-jitsu athletes (BJJ) and 42 persons in a control group (homogenously selected in terms of sex and age). The study used the SWLS scale to determine the satisfaction with life and the LOT-R test to determine the level of optimism. Descriptive parametric statistics were presented in order to show the analysed variables. Due to the number of subjects in groups, nonparametric statistics were used in the analysis – to analyse the differences, the Anova Kruskal-Wallis test; to analyse correlations between variables, the agglomerations method using Euclidean distances (single bond in space). In the analysis of the magnitude of the influence of variables on life satisfaction and optimism, parameter β was used – the significance of the parameter (p) was based on Wald's statistics.

Results

Analysis of intergroup differences for the judo, BJJ, and control groups revealed significant differences in education, social status, professional work, and health condition.
The compared psychological variables – quality of life and life orientation in terms of standardised results did not reveal significant differences; however, the dichotomous division of the quality of life allowed indicating the distinctness of the compared groups.
The analysis of multiple comparisons revealed that the differences only concerned the characteristics of the judo and the control groups, while the BJJ and the judo groups significantly differed in the quality and the length of their sports careers. Systems of characteristic features to explain the quality of life and life orientation were also searched for – the agglomerations method allowed indicating the distinctness of the BJJ and the judo groups in terms of the length of their sports careers.
Based on the conducted logistic regression analysis, the likelihood of high or low quality of life and of life orientation and optimism in both groups of athletes has been identified, and differences consistent with previous observations have been indicated.

Conclusions

The subjects involved in combat sports significantly differ from those who do not practice sports in terms of education, social status, work situation and health assessment. The presence of high or low life satisfaction differentiates the compared groups.
To Stem the Tide: Organizational Climate and the Locus of Knowledge Transfer
Authors: Di Stefano Giada , Micheli Maria Rita 
Published: February 2022

Prior work has maintained that organizations benefit from managing the transfer of proprietary knowledge. Transfer is often advantageous within organizational boundaries but may be harmful across them, because it might erode competitive advantage. Hence, we ask: How can organizations affect the direction in which knowledge flows? We examine the role of organizational climate as a governing mechanism for knowledge transfer. Our empirical strategy consists of a mixed-methods approach leveraging qualitative and experimental data over two cycles of theory building and theory testing. We start with an extensive field study of the European Organization for Nuclear Research (CERN), leveraging the insights from desk research, field observations, 53 interviews, and a laboratory-in-the-field experiment involving 518 physicists. We then provide a causal test of the emerging framework by means of two laboratory experiments with 389 participants. Our findings suggest employees are more likely to transfer knowledge to their colleagues when they identify as an integral part of the organization, but they would rather transfer knowledge to outside competitors when their organization encourages them to outperform coworkers. In the presence of an organizational climate that is unfavorable to preventing knowledge spillovers, we argue, organizations can redirect the locus of knowledge transfer internally by acting upon an individual employee’s job design and socialization regime. History: This paper has been accepted for the Organization Science Special Issue on Experiments in Organizational Theory. Funding: The authors acknowledge generous financial support from Bocconi University, the HEC Foundation of HEC Paris, and IESEG School of Management. Supplemental Material: The online appendix is available at https://doi.org/10.1287/orsc.2021.1551 .
Medical students' experiences working with midwives on NHS labour wards: a qualitative study
Authors: Maclean Emily , Llamas Ana 
Published: February 2022

Background Multidisciplinary team collaboration has been identified as a key factor in optimising intrapartum care. The way future doctors feel about their undergraduate placements with midwives is worth considering, given that this might influence their behaviour in the long term. This study aimed to investigate the experience of medical students working with midwives on NHS labour wards. Methods Qualitative thematic analysis was done on transcripts of in-depth interviews with 10 medical students from across England. These students had clinical experiences with midwives or were seeking to work with midwives, and had experiences of training during or after 2010. Results Midwives were described as ‘gatekeepers’, with the power either to open or close the labour room door to medical students. Participants described mixed feelings about midwives; some reportedly provided pivotal learning experiences, particularly regarding physiological labour and birth. Others were perceived as unsupportive. The dynamic with midwives was often linked to wider multidisciplinary team culture. Conclusions Despite national calls to improve multidisciplinary team relations and undergraduate experiences, this sample of medical students shows that some still perceive tension with midwives. This may affect future obstetricians' exposure to physiological birth at an impressionable time and also influence their multidisciplinary team behaviour. Research into midwives' perspective is needed, given that collaboration is a key factor in providing safer, more personalised care.
CT estimation of glenoid bone loss in anterior glenohumeral instability
Authors: Green Gemma L. , Arnander Magnus , Pearse Eyiyemi , Tennent Duncan 
Published: February 2022

Aims Recurrent dislocation is both a cause and consequence of glenoid bone loss, and the extent of the bony defect is an indicator guiding operative intervention. Literature suggests that loss greater than 25% requires glenoid reconstruction. Measuring bone loss is controversial; studies use different methods to determine this, with no clear evidence of reproducibility. A systematic review was performed to identify existing CT-based methods of quantifying glenoid bone loss and establish their reliability and reproducibility Methods A Preferred Reporting Items for Systematic reviews and Meta-Analyses-compliant systematic review of conventional and grey literature was performed. Results A total of 25 studies were initially eligible. Following screening, nine papers were included for review. Main themes identified compared 2D and 3D imaging, as well as linear- compared with area-based techniques. Heterogenous data were acquired, and therefore no meta-analysis was performed. Conclusion No ideal CT-based method is demonstrated in the current literature, however evidence suggests that surface area methods are more reproducible and lead to fewer over-estimations of bone loss, provided the views used are standardized. A prospective imaging trial is required to provide a more definitive answer to this research question. Cite this article: Bone Jt Open 2022;3(2):114–122.