bluuebunny/crossref_metadata_2025_split huggingface dataset:
Managing Environmental and Sustainability Challenges
Authors: Head Brian W. 
Published: March 2022

AbstractWicked problems and robust debates abound in environmental policy at local, national and global levels. Over several decades, governments have responded with policies to mitigate industrial pollution, slow the rapid depletion of scarce natural resources and protect biodiversity and ecological systems. The precautionary principle has been invoked to seek thorough assessment of environmental risks before approving economic development projects and technological innovations that might damage ecological assets and human health. Scientific researchers and community groups have lobbied for strong measures to protect biodiversity and promote resilient eco-systems. Resistance to reform has generally been led by conservative parties, corporate media networks and large business firms in traditional industry sectors. Policies for environmental protection have been developed by most national governments, in conjunction with international agreements that encourage collective action. The toolkit of policy instruments has expanded, including regulatory standards and market-based incentives. The role of scientific expertise in providing policy advice on environmental issues has been vital, but controversial. The chapter explores how science interacts with other sources of knowledge and opinion among practitioners and stakeholders. Climate change policy is analysed as an example of interconnected wicked problems, along with brief references to other environmental issues.
Improving Social Well-Being and Social Equity
Authors: Head Brian W. 
Published: March 2022

AbstractProtecting and enhancing the well-being of citizens is a central goal of modern governments. The specific social programs adopted in various countries reflect their local political and economic contexts. The range of problems considered is very extensive—such as public health services, education and training, social support services, crime and corrections and issues concerned with discrimination in relation to age, gender, ethnicity and religion. The core pillars of social policy—especially income support, health, education, social services and civil rights—broadly constitute the modern ‘welfare state’. All the social reforms were controversial when first proposed in earlier times. As public expectations gradually increased, so political ambitions correspondingly shifted. In most democracies, the problem of deep and enduring poverty, along with gender-based discrimination, came to be seen as unacceptable features of advanced societies. But many programs have remained controversial. Thus, the key dimensions of wicked problems—complexity, disagreement and uncertainty—have permeated social policy debates. The chapter includes a brief discussion of two case studies of wicked problems in action—policies to tackle homelessness and policies regulating drug use.
Policy Innovation in Turbulent Times
Authors: Head Brian W. 
Published: March 2022

AbstractInnovative solutions are increasingly recommended because many of the old-style solutions (see Chapter 10.1007/978-3-030-94580-0_3) are found to be ineffective. This chapter explores the felt need for greater innovation in tackling social, economic, technological and bio-health issues. Improved knowledge and understanding are required not only to appreciate and foster innovations, but also to identify appropriate ways to regulate new technologies. The chapter considers recent work on design methods for facilitating social innovation. Much of this work is aimed at the local level and place-based contexts, rather than aspiring to design mainstream programs at a national level. The chapter considers the arguments in favour of social experimentation and co-design processes for addressing wicked problems. It concludes with some observations on the contemporary politics of populism and opinion-based policy ideas.
Die somatische Dysfunktion der Halswirbelsäule und ihr komplexes klinisches Bild
Authors: Wagner Florian Max-Josef 
Published: March 2022

ZusammenfassungDie segmentale und somatische Dysfunktion der Halswirbelsäule kann aufgrund komplexer funktionell-anatomischer und neurophysiologischer Verschaltungen dem Untersucher einen variantenreichen, aber teils schwer nachvollziehbaren Symptomkomplex bieten. Auf Grundlage von zervikotrigeminalen und intersegmentalen Konvergenzen im Bereich des Rückenmarks der Halswirbelsäule und des Hirnstammes lassen sich diese Symptome, die als zervikozephales Syndrom und Zervikobrachialgie zusammengefasst werden, nachvollziehen. Eine fundierte manualmedizinische Untersuchung kann, nach Ausschluss bedrohlicher Differenzialdiagnosen, das Vorliegen einer Blockierung der Halswirbelsäule als mögliche Ursache oder als Teilaspekt der Beschwerden demaskieren. Eine manualmedizinische Behandlung mit dem Setzen gezielter antinozizeptiver propriozeptiver Reize ist dann eine sinnvolle therapeutische Option.
Evaluation of CYP2C19 activity using microdosed oral omeprazole in humans
Authors: Elbe Annika , Foerster Kathrin Isabelle , Blank Antje , Rose Peter , Burhenne Jürgen , Haefeli Walter Emil , Mikus Gerd 
Published: March 2022

Abstract
Purpose
To investigate the suitability of microdosed oral omeprazole for predicting CYP2C19 activity in vivo in combination with simultaneous assessment of CYP3A and CYP2D6 activity using both microdosed midazolam and yohimbine.

Methods
An open, fixed-sequence study was carried out in 20 healthy participants. Single microdosed (100 µg) and therapeutic (20 mg) doses of omeprazole were evaluated without comedication and after administration of established CYP2C19 perpetrators fluconazole (inhibition) and rifampicin (induction). To prevent degradation of the uncoated omeprazole microdose, sodium bicarbonate buffer was administered. The pharmacokinetics of omeprazole and its 5-hydroxy-metabolite were assessed as well as the pharmacokinetics of midazolam and yohimbine to estimate CYP3A4 and CYP2D6 activity.

Results
Calculated pharmacokinetic parameters after administration of 100 µg and 20 mg omeprazole in healthy subjects suggest dose proportionality. Omeprazole clearance was significantly decreased by fluconazole from 388 [95% CI: 266–565] to 47.2 [42.8–52.0] mL/min after 20 mg omeprazole and even further after 100 µg omeprazole (29.4 [24.5–35.1] mL/min). Rifampicin increased CYP2C19-mediated omeprazole metabolism. The omeprazole hydroxylation index was significantly related to omeprazole clearance for both doses. Both fluconazole and rifampicin altered CYP3A4 activity whereas no change of CYP2D6 activity was observed at all.

Conclusions
Microdosed oral omeprazole is suitable to determine CYP2C19 activity, also during enzyme inhibition and induction. However, the administration of sodium bicarbonate buffer also had a small influence on all victim drugs used.

Trial registration
EudraCT: 2017–004270-34.
BEGEV salvage regimen in relapsed/refractory classical Hodgkin lymphoma: a real-life experience
Authors: Stefoni Vittorio , Argnani Lisa , Carella Matteo , Casadei Beatrice , Morigi Alice , Lolli Ginevra , Broccoli Alessandro , Pellegrini Cinzia , Nanni Laura , Coppola Paolo Elia , Zinzani Pier Luigi 
Published: March 2022

Abstract
Purpose
One of the most critical issues in the management of Hodgkin lymphoma (HL) patients who resulted as primary relapsed or refractory is to obtain a minimal disease status before autologous stem cell transplantation (ASCT). Finding a salvage regimen able to induce this status without severe toxicity would represent a major achievement in this setting.

Methods
A single‐center retrospective study was conducted to assess effectiveness and safety of BEGEV (bendamustine, gemcitabine, and vinorelbine) regimen as first salvage setting prior to ASCT in HL patients.

Results
Forty-three patients were treated in our institution between October 2017 and November 2020. Median age at BEGEV therapy was 35.0 years (range 17.2– 70.0), and the median time from frontline therapy to the first cycle of BEGEV was 79.5 days (range 4–2267). At the end of treatment, 31 patients achieved a complete response (CR), with an overall response rate of 76.7%. Forty-one patients harvested CD34+ cells and 35/43 (81.4%) patients underwent ASCT. With a median follow‐up of 22 months, 4 CR patients had disease relapse, yielding an estimated disease-free survival of 73.9% at 34 months. The estimated 2‐year progression-free survival was 66.7%. Response to first-line chemotherapy did not significantly influence prognosis.

Conclusions
BEGEV regimen was well tolerated, and reversible haematological toxic effects were the most common adverse events. Real-life data on BEGEV regimen as first salvage setting showed a relevant rate of objective responses and a limited myelotoxicity with no impairment of a subsequent mobilization of peripheral blood stem cells.
Cancer-related fatigue in patients treated with mistletoe extracts: a systematic review and meta-analysis
Authors: Pelzer Florian , Loef Martin , Martin David D. , Baumgartner Stephan 
Published: March 2022

Abstract

Purpose
Cancer-related fatigue remains one of the most prevalent and distressing symptoms experienced by cancer patients. Effective treatments for cancer-related fatigue are needed. The objective of this meta-analysis is to determine the impact of mistletoe extracts as a pharmacological treatment for the management of cancer-related fatigue.

Methods
We included randomized clinical trials (RCTs) and non-randomized studies of interventions (NRSIs) in cancer patients. Inclusion criteria were cancer-related fatigue severity or prevalence as an outcome and testing of mistletoe extracts compared to control groups. We searched Medline (EuropePMC), Embase, the Cochrane Central Register of Controlled Trials, Clinicaltrials.gov, and opengrey.org through October 2020. We assessed the risk of bias using the Cochrane risk of bias tools for RCTs and NRSIs and conducted a meta-analysis.

Results
We performed one meta-analysis with 12 RCTs, including 1494 participants, and one meta-analysis with seven retrospective NRSIs, including 2668 participants. Heterogeneity between the studies was high in both meta-analyses. Most studies had a high risk of bias. A random-effects model showed for RCTs a standardized mean difference of –0.48 (95% confidence interval –0.82 to –0.14; p = 0.006) and for NRSIs an odds ratio of 0.36 (95% confidence interval 0.20 to 0.66; p = 0.0008).

Conclusion
Treatment with mistletoe extracts shows a moderate effect on cancer-related fatigue of similar size to physical activity. These results need to be confirmed by more placebo-controlled trials. Future trials should investigate different treatment durations and their effect on cancer-related fatigue in post-treatment cancer survivors.
Trial registration.
This meta-analysis has been registered under the PROSPERO registration number CRD42020191967 on October 7, 2020.
Specific and sensitive GC–MS analysis of hypusine, Nε-(4-amino-2-hydroxybutyl)lysine, a biomarker of hypusinated eukaryotic initiation factor eIF5A, and its application to the bi-ethnic ASOS study
Authors: Baskal Svetlana , Kaiser Annette , Mels Catharina , Kruger Ruan , Tsikas Dimitrios 
Published: March 2022

AbstractHypusination is a unique two-step enzymatic post-translational modification of the Nε-amino group of lysine-50 of the eukaryotic initiation factor 5A (eIF5A). We developed a specific and sensitive gas chromatography–mass spectrometry (GC–MS) method for the measurement of biological hypusine (Hyp), i.e., Nε-(4-amino-2-hydroxybutyl)lysine. The method includes a two-step derivatization of Hyp: first esterification with 2 M HCl in CH3OH (60 min, 80 °C) to the methyl ester (Me) and then acylation with penta-fluoro-propionic (PFP) anhydride in ethyl acetate (30 min, 65 °C). Esterification with 2 M HCl in CD3OD was used to prepare the internal standard. The major derivatization product was identified as the un-labelled (d0Me) and the deuterium-labelled methyl esters (d3Me) derivatives: d0Me-Hyp-(PFP)5 and d3Me-Hyp-(PFP)5, respectively. Negative-ion chemical ionization generated the most intense ions with m/z 811 for d0Me-Hyp-(PFP)5 and m/z 814 for the internal standard d3Me-Hyp-(PFP)5. Selected-ion monitoring of m/z 811 and m/z 814 was used in quantitative analyses. Free Hyp was found in spot urine samples (10 µL) of two healthy subjects at 0.60 µM (0.29 µmol Hyp/mmol creatinine) in the female and 1.80 µM (0.19 µmol Hyp/mmol creatinine) in the male subject. The mean accuracy of the method in these urine samples spiked with 1–5 µM Hyp was 91–94%. The limit of detection (LOD) of the method is 1.4 fmol Hyp. The method was applied to measure the urinary excretion rates of Hyp in healthy black (n = 38, age 7.8 ± 0.7 years) and white (n = 41, age 7.7 ± 1.0 years) boys of the Arterial Stiffness in Offspring Study (ASOS). The Hyp concentrations were 3.55 [2.68–5.31] µM (range 0.54–9.84 µM) in the black boys and 3.87 [2.95–5.06] µM (range 1.0–11.7 µM) in the white boys (P = 0.64). The creatinine-corrected excretion rates were 0.25 [0.20–0.29] µmol/mmol (range 0.11–0.36 µmol/mmol) in the black boys and 0.26 [0.21–0.30] µmol/mmol (range 0.10–0.45 µmol/mmol) in the white boys (P = 0.82). These results suggest that there is no ethnic-related difference in the ASOS population in the eIF5A modification. Remarkable differences were found between black and white boys with respect to correlations of urinary Hyp with amino acids and advanced glycation end-products of Lys, Arg and Cys. Deoxyhypusine, formally the direct precursor of Hyp, seems not to be excreted in the urine by healthy subjects.
Understanding the challenges faced by Michigan’s family farmers: race/ethnicity and the impacts of a pandemic
Authors: Taylor Dorceta E. , Farias Lina M. , Kahan Lia M. , Talamo Julia , Surdoval Alison , McCoy Ember D. , Daupan Socorro M. 
Published: March 2022

AbstractMichigan is a critical agricultural state, and small family farms are a crucial component of the state’s food sector. This paper examines how the race/ethnicity of the family farm owners/operators is related to farm characteristics, financing, and impacts of the pandemic. It compares 75 farms owned/operated solely by Whites and 15 with People of Color owners/operators. The essay examines how farmers finance their farm operations and the challenges they face doing so. The article also explores how the Coronavirus-19 (COVID-19) pandemic affected farming operations, the financial viability of farms, and how farmers responded to the challenges posed by the pandemic. The study found that People of Color farm owners/operators were younger than White farm owners/operators. The People of Color farm owners/operators tended to manage smaller farms for shorter periods than White farm owners/operators. Though two-thirds of the Farmers of Color owned their farms, they were more financially vulnerable than White farm owners/operators. The farmers studied had difficulty obtaining loans to finance their farms. Farmers reported increasing requests from people for food assistance during the pandemic. Farmers responded to the pandemic by participating in government programs such as the Farm to Families Food Box Program that purchased their produce. It allowed farmers to supply emergency food assistance programs with products from their farms. The products went to families receiving food assistance from soup kitchens, food banks, and other community-based nonprofits.
UAV swarm path planning with reinforcement learning for field prospecting
Authors: Puente-Castro Alejandro , Rivero Daniel , Pazos Alejandro , Fernandez-Blanco Enrique 
Published: March 2022

AbstractThere has been steady growth in the adoption of Unmanned Aerial Vehicle (UAV) swarms by operators due to their time and cost benefits. However, this kind of system faces an important problem, which is the calculation of many optimal paths for each UAV. Solving this problem would allow control of many UAVs without human intervention while saving battery between recharges and performing several tasks simultaneously. The main aim is to develop a Reinforcement Learning based system capable of calculating the optimal flight path for a UAV swarm. This method stands out for its ability to learn through trial and error, allowing the model to adjust itself. The aim of these paths is to achieve full coverage of an overflight area for tasks such as field prospection, regardless of map size and the number of UAVs in the swarm. It is not necessary to establish targets or to have any previous knowledge other than the given map. Experiments have been conducted to determine whether it is optimal to establish a single control for all UAVs in the swarm or a control for each UAV. The results show that it is better to use one control for all UAVs because of the shorter flight time. In addition, the flight time is greatly affected by the size of the map. The results give starting points for future research, such as finding the optimal map size for each situation.
Isotropic 3D compressed sensing (CS) based sequence is comparable to 2D-LGE in left ventricular scar quantification in different disease entities
Authors: Fenski Maximilian , Grandy Thomas Hiroshi , Viezzer Darian , Kertusha Stela , Schmidt Michaela , Forman Christoph , Schulz-Menger Jeanette 
Published: March 2022

AbstractThe goal of this study was to evaluate a three-dimensional compressed sensing (3D-CS) LGE prototype sequence for the detection and quantification of myocardial fibrosis in patients with chronic myocardial infarction (CMI) and myocarditis (MYC) compared with a 2D-LGE standard. Patients with left-ventricular LGE due to CMI (n = 33) or MYC (n = 20) were prospectively recruited. 2D-LGE and 3D-CS images were acquired in random order at 1.5 Tesla. 3D-CS short axis (SAX) images were reconstructed corresponding to 2D SAX images. LGE was quantitatively assessed on patient and segment level using semi-automated threshold methods. Image quality (4-point scoring system), Contrast-ratio (CR) and acquisition times were compared. There was no significant difference between 2D and 3D sequences regarding global LGE (%) (CMI [2D-LGE: 11.4 ± 7.5; 3D-LGE: 11.5 ± 8.5; p = 0.99]; MYC [2D-LGE: 27.0 ± 15.7; 3D-LGE: 26.2 ± 13.1; p = 0.70]) and segmental LGE-extent (p = 0.63). 3D-CS identified papillary infarction in 5 cases which was not present in 2D images. 2D-LGE acquisition time was shorter (2D: median: 06:59 min [IQR: 05:51–08:18]; 3D: 14:48 min [12:45–16:57]). 3D-CS obtained better quality scores (2D: 2.06 ± 0.56 vs. 3D: 2.29 ± 0.61). CR did not differ (p = 0.63) between basal and apical regions in 3D-CS images but decreased significantly in 2D apical images (CR basal: 2D: 0.77 ± 0.11, 3D: 0.59 ± 0.10; CR apical: 2D: 0.64 ± 0.17, 3D: 0.53 ± 0.11). 3D-LGE shows high congruency with standard LGE and allows better identification of small lesions. However, the current 3D-CS LGE sequence did not provide PSIR reconstruction and acquisition time was longer.
A Half Century of Progress in US Student Achievement: Agency and Flynn Effects, Ethnic and SES Differences
Authors: Shakeel M. Danish , Peterson Paul E. 
Published: March 2022

AbstractPolicymakers, conceptualized here as principals, disagree as to whether US student performance has changed over the past half century. To inform conversations, agents administered seven million psychometrically linked tests in math (m) and reading (rd) in 160 survey waves to national probability samples of cohorts born between 1954 and 2007. Estimated change in standard deviations (sd) per decade varies by agent (m: –0.10sd to 0.27sd, rd: –0.02sd to 0.12sd). Consistent with Flynn effects, median trends show larger gains in m (0.19sd) than in rd (0.04sd), though rates of progress for cohorts born since 1990 have increased in rd but slowed in m. Greater progress is shown by students tested at younger ages (m: 0.31sd, rd: 0.08sd) than when tested in middle years of schooling (m: 0.17sd, rd: 0.03sd) or toward the end of schooling (m: 0.06sd, rd: 0.02sd). Young white students progress more slowly (m: 0.28sd, rd: 0.09sd) than Asian (m: 46sd, rd: 0.28sd), black (m: 0.36sd, rd: 0.19sd), and Hispanic (m: 0.29sd, rd: 0.13sd) students. These ethnic differences generally attenuate as students age. Young students in the bottom quartile of the SES distribution show greater progress than those in the top quartile (difference in m: 0.08sd, in rd: 0.15sd), but the reverse is true for older students. Moderators likely include not only changes in families and schools but also improvements in nutrition, health care, and protection from contagious diseases and environmental risks. International data suggest that subject and age differentials may be due to moderators more general than just the United States.
20 Years of global climate change governance research: taking stock and moving forward
Authors: Pattberg Philipp , Kaiser Cille , Widerberg Oscar , Stripple Johannes 
Published: March 2022

AbstractResearch on global climate change governance is no longer primarily concerned with the international legal regime, state practice and its outcomes, but rather scrutinizes the intricate interactions between the public and the private in governing climate change. This broad trend has also taken center stage within the pages of INEA. Two decades after its establishment, we sketch the main theoretical debates, conceptual innovations and empirical findings on global climate change governance and survey the new generation of climate governance scholarship. In more detail, we sketch how climate governance research has developed into three innovative sub-debates, building on important conceptualizations and critical inquiries of earlier debates. Our aim is not so much to provide an all-encompassing assessment of global climate change governance scholarship in 2022, but rather to illustrate in what important ways current research is different from research in the early phase of INEA, and what we have learned in the process. First, we discuss scholarship on the bottom-up nature of climate governance, developing from earlier ideas on agency beyond the state and the transnationalization of governance arenas. Second, we review contributions that have more systematically engaged with the concept of governance architectures, resulting in a stimulating new academic debate on the characteristics of complex governance systems and the consequences of governance complexity and fragmentation. Third, we note a distinct normative turn in global environmental scholarship in general and global climate governance in particular, associated with question of access, accountability, allocation, fairness, justice and legitimacy. The assessment of each of these debates is centered around questions of effective and legitimate climate governance to counter the climate emergency. Finally, as a way of concluding, we critically reflect on our own scholarly shortcomings and suggest a modest remedy.