bluuebunny/crossref_metadata_2025_split huggingface dataset:
How to promote ‘discipline without tough love’ during pregnancy: a randomized controlled trial
Authors: Suzuki Shunji 
Published: October 2022

Background: In Japan, the effect of education using the leaflet ‘Discipline Without Tough Love’ on mothers during caring for their infants have been reported. We examined the effect of this education on pregnant Japanese women. Methods: The present study was a prospective investigation of all Japanese women with singleton pregnancies who visited our hospital for a perinatal visit at 20-23 weeks’ gestation between November 2017 and March 2018 and gave birth at ≥ 37 weeks’ gestation at our hospital. We examined the maternal feelings (bonding situation) to babies of women who received the leaflet in comparison with that in women who did not receive it during the health check-up performed routinely at one month after delivery using the Japanese version of the Mother-to-Infant Bonding Scale. Results: There were no significant differences in maternal feelings for their babies between the two groups of women. Conclusions: We did not identify any effect of health consultations cased on ‘Discipline Without Tough Love’ during pregnancy on maternal feelings toward babies at one month after delivery. A further study to enlighten pregnant women about parenting without corporal punishment will be needed in Japan. Registration: Japan Registry of Clinical Trials 1030190112; registered on 5 October 2019.
A preliminary study of soluble CD14 levels in the serum of patients with hidradenitis suppurativa as a marker of “leaky gut”
Authors: Johnston Daniel G W , Hambly Roisin , Kearney Niamh , Tobin Desmond J , Kirby Brian 
Published: October 2022

Background: Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease characterized by recurring inflammatory lesions resulting from the rupture of occluded hair follicles. The aetiology of this disease is poorly understood, but it is clear that numerous immunological pathways are dysregulated, both locally and systemically. It is also increasingly appreciated that the gut and skin microbiomes of HS patients are deleteriously altered. Several lines of evidence indicate that this may lead to a “leaky gut” in HS patients, including the strong prevalence of Crohn’s disease as a co-morbidity, resulting in excessive bacterial translocation and lipopolysaccharide (LPS) circulation. Methods: We sought to investigate whether soluble CD14, a proxy for circulating LPS and subsequent excessive monocyte activation, was elevated in the serum of HS patients. sCD14 levels in HS patients from a Dublin hospital were assessed using ELISA. Results: We found that there was no significant difference in sCD14 levels present in the plasma of 12 healthy controls and 17 HS patients. Conclusions: Our results indicate that sCD14 is not a useful marker of inflammation in HS patients and does not indicate a grossly compromised gut epithelial barrier.
Efficient and fabrication error tolerant grating couplers on the InP membrane on silicon platform
Authors: Kashi A. A. , van der Tol J. J. G. M. , Williams K. A. , Jiao Y. 
Published: October 2022

In order to couple light between photonic integrated circuits and
optical fibers, grating couplers are commonly employed. This paper
describes the design and fabrication of deep and shallow-etched
grating couplers with a metal back-reflector with record low insertion
losses in InP-based platforms. The measured insertion losses for deep
and shallow-etched gratings are 2.4 and 2.6 dB, respectively.
Additionally, fabrication error tolerances in shallow etched grating
couplers have been examined experimentally, which showed high
tolerance of this structure toward the grating period and fill
factor.
Hemoadsorption in the critically ill—Final results of the International CytoSorb Registry
Authors: Hawchar Fatime , Tomescu Dana , Träger Karl , Joskowiak Dominik , Kogelmann Klaus , Soukup Jens , Friesecke Singrun , Jacob David , Gummert Jan , Faltlhauser Andreas , Aucella Filippo , van Tellingen Martijn , Malbrain Manu L. N. G. , Bogdanski Ralph , Weiss Günter , Herbrich Andreas , Utzolino Stefan , Nierhaus Axel , Baumann Andreas , Hartjes Andreas , Henzler Dietrich , Grigoryev Evgeny , Fritz Harald , Bach Friedhelm , Schröder Stefan , Weyland Andreas , Gottschaldt Udo , Menzel Matthias , Zachariae Olivier , Novak Radovan , Berden Jernej , Haake Hendrik , Quintel Michael , Kloesel Stephan , Kortgen Andreas , Stecher Stephanie , Torti Patricia , Nestler Frieder , Nitsch Markus , Olboeter Detlef , Muck Philip , Findeisen Michael , Bitzinger Diane , Kraßler Jens , Benad Martin , Schott Martin , Schumacher Ulrike , Molnar Zsolt , Brunkhorst Frank Martin 
Published: October 2022

The aim of the current paper is to summarize the results of the International CytoSorb Registry. Data were collected on patients of the intensive care unit. The primary endpoint was actual in-hospital mortality compared to the mortality predicted by APACHE II score. The main secondary endpoints were SOFA scores, inflammatory biomarkers and overall evaluation of the general condition. 1434 patients were enrolled. Indications for hemoadsorption were sepsis/septic shock (N = 936); cardiac surgery perioperatively (N = 172); cardiac surgery postoperatively (N = 67) and “other” reasons (N = 259). APACHE-II-predicted mortality was 62.0±24.8%, whereas observed hospital mortality was 50.1%. Overall SOFA scores did not change but cardiovascular and pulmonary SOFA scores decreased by 0.4 [-0.5;-0.3] and -0.2 [-0.3;-0.2] points, respectively. Serum procalcitonin and C-reactive protein levels showed significant reduction: -15.4 [-19.6;-11.17] ng/mL; -17,52 [-70;44] mg/L, respectively. In the septic cohort PCT and IL-6 also showed significant reduction: -18.2 [-23.6;-12.8] ng/mL; -2.6 [-3.0;-2.2] pg/mL, respectively. Evaluation of the overall effect: minimal improvement (22%), much improvement (22%) and very much improvement (10%), no change observed (30%) and deterioration (4%). There was no significant difference in the primary outcome of mortality, but there were improvements in cardiovascular and pulmonary SOFA scores and a reduction in PCT, CRP and IL-6 levels.
Trial registration: ClinicalTrials.gov Identifier: NCT02312024 (retrospectively registered).
Work-related stressors and mental health among LGBTQ workers: Results from a cross-sectional survey
Authors: Owens Benjamin , Mills Suzanne , Lewis Nathaniel , Guta Adrian 
Published: October 2022

Purpose
Lesbian, gay, bisexual, transgender, and queer (LGBTQ) individuals experience high rates of adverse mental health outcomes due to the stressors they experience in families, communities, and society more broadly. Work and workplaces have the potential to influence these outcomes given their ability to amplify minority stress, and their ability to influence social and economic wellbeing in this already marginalized population. This study aims to identify how sociodemographic characteristics and characteristics of work, including degree of precarity, industry and perceived workplace support for LGBTQ people, influence self-reported mental health among LGBTQ people in two Canadian cities.

Methods
Self-identified LGBTQ workers ≥16 years of age (n = 531) in Sudbury and Windsor, Ontario, Canada were given an online survey between July 6 and December 2, 2018. Multivariate ordinal logistic regression was used to calculate odds ratios (OR) to evaluate differences in gender identity, age, income, industry, social precarity, work environment, and substance use among workers who self-reported very poor, poor, or neutral mental health, compared with a referent group that self-reported good or very good mental health on a five-point Likert scale about general mental health.

Results
LGBTQ workers with poor or neutral mental health had greater odds of: being cisgender women or trans compared with being cisgender men; being aged <35 years compared with ≥35 years; working in low-wage service sectors compared with blue collar jobs; earning <$20,000/year compared with ≥$20,000/year; working in a non-standard work situation or being unemployed compared with working in full-time permanent employment; feeling often or always unable to schedule time with friends due to work; feeling unsure or negative about their work environment; and using substances to cope with work.

Conclusions
Both precarious work and unsupportive work environments contribute to poor mental health among LGBTQ people. These factors are compounded for trans workers who face poorer mental health than cis-LGBQ workers in similar environments.
Perceived listening ability and hearing loss: Systematic review and qualitative meta-synthesis
Authors: Hughes Sarah E. , Boisvert Isabelle , McMahon Catherine M. , Steyn Anne , Neal Katie 
Published: October 2022

Background
Hearing loss (HL) can affect communication in complex ways. Understanding how adults with HL reflect on and conceptualise the way they listen (metacognition) is required if interventions, and the outcome measures used to evaluate them, are to address barriers to functional communication arising from HL.

Objectives
This study describes how adults with HL experience and report the processes, behaviours, and components of listening, as presented in published studies.

Design
Systematic review and meta-synthesis of qualitative studies.

Methods
Systematic searches identified English-language, peer-reviewed journal articles reporting the results of qualitative or mixed-methods studies of adults’ with HL perceived listening abilities. Medline, PsychInfo, Web of Science, Embase, and Google Scholar were searched from inception to November 2021. Handsearching reference lists of included studies identified additional studies for inclusion. The Critical Appraisal Skills Programme (CASP) qualitative checklist was used to appraise studies’ methodological quality. Data from included studies were analysed using thematic meta-synthesis. The Grading of Recommendations Assessment, Development and Evaluation (GRADE) Confidence in the Evidence from Reviews of QUALitative (CERQual) approach assessed confidence in the review findings. Two reviewers independently completed all screening and quality appraisal. Thematic meta-synthesis and GRADE CERQual assessment was completed by one reviewer and confirmed by a second reviewer. Discrepancies were resolved through discussion.

Results
Data from 46 studies were included in the review. Thematic meta-synthesis identified six descriptive themes: 1) perceived listening ability; 2) external modifiers; 3) psychosocial impacts of hearing loss; 4) communication partner perspectives; 5) self-efficacy for listening; and 6) cognitive load. GRADE CERQual ratings for descriptive themes ranged from low to moderate confidence. Descriptive themes were related by analytic themes of liminality and reciprocity.

Conclusions
Adults with HL provide in-depth accounts of components and processes of listening, with studies reporting both cognitive and affective experiences consistent with theoretical models of metacognition. The findings will inform content generation for a hearing-specific patient-reported outcome measure of perceived listening ability in everyday communication.
Heart rate variability and the risk of heart failure and its subtypes in post-menopausal women: The Women’s Health Initiative study
Authors: Baig Muhammad , Moafi-Madani Miremad , Qureshi Reema , Roberts Mary B. , Allison Matthew , Manson JoAnn E. , LaMonte Michael J. , Liu Simin , Eaton Charles B. 
Published: October 2022

Background
Low heart rate variability (HRV), a measure of autonomic imbalance, is associated with increased risk of coronary heart disease (CHD) and heart failure (HF). However, its relationship with HF subtypes; heart failure with preserved ejection fraction (HFpEF) and heart failure with reduced ejection fraction (HFrEF) has not been studied prior.

Methods and findings
We conducted a longitudinal study in Women’s Health Initiative study cohort to investigate the association of baseline quartiles of resting heart rate (rHR) and HRV measures; SDNN (SD of normal-to-normal RR interval) and RMSSD (root mean square of successive difference of RR interval) measured by twelve-lead electrocardiogram (ECG) on enrollment, with the risk of hospitalized HF and its subtypes. Total of 28,603 post-menopausal women, predominantly non-Hispanic whites (69%), with a mean (SD) age of 62.6 (7.1) years, free of baseline CHD and HF were included. In a fully adjusted cox-proportional hazards regression model which adjusted for age, race, BMI, alcohol intake, education, physical activity, hyperlipidemia, hypertension, left ventricular hypertrophy, use of beta-blocker, calcium-channel blocker, hormone therapy, and time-varying incident CHD, the hazard ratios of lowest quartile of HRV (Q1) with HF risk were significant (Q1 SDNN compared to Q4 SDNN: 1.22, 95% CI 1.07, 1.39; Q1 RMSSD compared to Q4 RMSSD: 1.17, 95% CI 1.02, 1.33). On subgroup analysis of HF subtypes, low HRV was associated with elevated HFpEF risk (Q1 vs Q4 SDNN: 1.22, 95% CI 1.02, 1.47) but not with HFrEF (Q1 vs Q4 SDNN: 1.19, 95% CI 0.95, 1.50; Q1 RMSSD: 1.13, 95% CI 0.90, 1.43).

Conclusion
Low HRV is associated with elevated overall hospitalized HF risk and HFpEF risk in post-menopausal women. Whether interventions to increase HRV through healthy lifestyle changes will decrease HF risk warrants further investigation.
Depression and polymorphism G-174C (rs1800795) of the <I>IL-6</I> gene in an open population of 25–44 year old in Russia/Siberia (WHO international program MONICA-psychosocial)
Authors: Gafarov V. V. , Gromova E. A. , Panov D. O. , Maksimov V. N. , Gagulin I. N. , Gafarova A. V. 
Published: October 2022

Objective: to study the association of the G-174C (rs1800795) polymorphism of the IL-6 gene with depression in an open population of 25–44 year old in Novosibirsk.Patients and methods. In 2013–2016 years we examined 403 men (mean age – 34±0.4 years, response – 71%) and 531 women (mean age – 35±0.4 years, response – 72%) from an open population of 25–44 year old residents of the Oktyabrsky district, Novosibirsk, the sample was representative. Depression was assessed using the MONICA-MOPSY psychosocial questionnaire. Genotyping of the studied gene polymorphisms was carried out in the Laboratory of Molecular Genetic Research of Scientific Research Institute for Therapy and Preventive Medicine, Federal Research Center Institute of Cytology and Genetics, Russian Academy of Sciences, Novosibirsk.Results and discussion. A severe level of depression occurred in 12.8% of the population, among men – in 8.9%, among women – in 15.8%; and moderate level – in 24.5% of the population (among men – 21.3%, among women – 26.9%). The most common in the population was the heterozygous C/G genotype (45.1%), the G/G genotype was observed in 34.6% of the population and, finally, C/C in 20.3% of participants. The most common allele of the IL-6 gene of the G-174C polymorphism (rs1800795) was the G allele in 57.5% of the population, and the C allele in only 42.5%. Among carriers of the G/G genotype of the IL-6 gene, a moderate (39.7%) or severe level of depression (37.3%) prevailed, while there was no depression in the carriers of the C/C genotype of the IL-6 gene (24.2%; χ2 = 10.962; df=4; p=0.027). Carrying the C/G genotype of the IL-6 gene increased the chance of developing a severe level of depression by almost 2.9–3.3 times in comparison with the carriage of the C/C genotype. Among carriers of the G/G genotype of the IL-6 gene, a severe level of depression was 3.3 times more common than in carriers of the C/C genotype. Individuals carrying the G allele of the IL-6 gene were 1.6 times more likely to experience a severe level of depression than those carrying the C allele.Conclusion. The data obtained suggest that the carriage of the G allele of the G-174C polymorphism (rs1800795) of the IL-6 gene may be associated with a severe level of depression.
Study of the role of carriage of single nucleotide variants of the IL-1β, TNFA, BDNF, NTRK-2 genes in the development and clinical features of temporal lobe epilepsy
Authors: Panina Yu. S. , Domoratskaya E. A. , Paramonova A. I. , Dmitrenko D. V. 
Published: October 2022

Temporal lobe epilepsy (TE) is the most common form of focal epilepsy in adults with a high rate of drug-resistant course. In the Russian Federation studies of the contribution of the carriage of single nucleotide variants of genes (SNGs) encoding proteins of neuroinflammation and neurodegeneration to the development of TE have not been previously carried out.Objective: to study the association of SNGs rs16944 and rs1143634 of the IL-1β gene, rs1800629 of the TNFA gene, rs6265 of the BDNF gene, rs3780645 of the NTRK-2 gene with the risk of development, clinical and neuroimaging features of TE.Patients and methods. The study included 166 patients with TE and 203 healthy volunteers living in the Siberian Federal District. The study included clinical, neurophysiological, neuroradiological, and laboratory work-up. Investigation of the carriage of SNGs rs16944 (-511T/C) and rs1143634 (+3954C/T) of the IL-1β gene, rs1800629 (G-308A) of the TNFA gene, rs6265 (G/A) of the BDNF gene, rs3780645 (C/T) and rs2289656 (C/T) of the NTRK-2 gene was carried out by real-time polymerase chain reaction. Results and discussion. The prognostically unfavorable role of carriage of the A allele and the GA rs1800629 genotype of the TNFA gene in the development of TE, the GA rs6265 genotype of the BDNF gene in the development of TE with hippocampal sclerosis was established. Carrying the genotype AA rs1800629 of the TNFA gene in patients with TE reduces the risk of polytherapy with antiepileptic drugs.Conclusion. The study of neuroinflammation and neurodegeneration processes is important both from a physiological point of view and from the point of view of searching for the TE development markers, which make it possible to predict and evaluate the rate of disease progression, help to determine the tactics of treatment, and evaluate its effectiveness. In this regard, at present, the identification of potential genetic markers remains a task of high priority.
Peran Nomor Inventaris Sebagai Sumber Informasi Jumlah Koleksi Pustaka: Studi Kasus pada Perpustakaan SD Negeri Manyaran 01 Semarang
Authors: Handayani Tri 
Published: October 2022

Pencatatan nomor inventaris merupakan salah satu sub kegiatan pada inventarisasi koleksi perpustakaan. Nomor tersebut dicatat pada Buku Inventaris. Nomor inventaris merupakan nomor unik dan setiap koleksi diberikan nomor yang berbeda. Dengan demikian nomor inventaris koleksi perpustakaan memiliki peran penting untuk mengetahui jumlah koleksi yang dimiliki perpustakaan secara akurat. Selain itu, nomor inventaris merupakan kode utama yang diperlukan pada penerapan program otomatisasi koleksi perpustakaan. Penelitian ini menggunakan metode observasi, wawancara, dokumen kebijakan, partisipasi. Pendekatan Ilmu Perpustakaan digunakan dalam penelitian ini. Hasil penelitian menunjukkan, bahwa Buku Inventaris yang direkomendasikan peneliti kepada perpustakaan ini pada penelitian sebelumnya perlu dilengkapi dengan pencantuman nomor inventaris yang logis dan ilmiah. Visi dan Misi perpustakaan yang dimiliki perpustakaan SD Negeri Manyaran 01 Semarang sangat jelas. Keberadaan visi dan misi tersebut, serta sikap kooperatif Kepala Sekolah beserta pengelola perpustakaan sekolah merupakan unsur penting bagi keberhasilan penelitian ini. Sehubungan dengan keinginan Kepala Sekolah beserta jajarannya agar program otomatisasi perpustakaan diterapkan di perpustakaan sekolah tersebut, maka pencantuman nomor inventaris pada Buku Inventaris sangat direkomendasikan oleh peneliti.
Existence and uniqueness of solutions to higher order fractional partial differential equations with purely integral conditions
Authors: Chergui Djamila , Merad Ahcene , Pinelas Sandra 
Published: October 2022

Abstract
In this paper, we prove the existence and uniqueness of Caputo time fractional pseudo-hyperbolic
equations of higher order with purely nonlocal conditions of integral type.
We use an a priori estimate method; the so-called energy inequalities method,
based on some functional analysis tools, is developed for a Caputo time fractional of

2
⁢
m

{2m}

-th and

(

2
⁢
m

+
1

)

{(2m+1)}

-th order and the density of the range of the operator generated by the considered problem.
Using the Laplace transform and homotopy perturbation, we find a semi-analytical solution.
Finally, we give some examples for illustration.
The next wave of innovation in laboratory automation: systems for auto-verification, quality control and specimen quality assurance
Authors: Brown A. Shane , Badrick Tony 
Published: October 2022

Abstract
Laboratory automation in clinical laboratories has made enormous differences in patient outcomes, with a wide range of tests now available that are accurate and have a rapid turnaround. Total laboratory automation (TLA) has mechanised tube handling, sample preparation and storage in general chemistry, immunoassay, haematology, and microbiology and removed most of the tedious tasks involved in those processes. However, there are still many tasks that must be performed by humans who monitor the automation lines. We are seeing an increase in the complexity of the automated laboratory through further platform consolidation and expansion of the reach of molecular genetics into the core laboratory space. This will likely require rapid implementation of enhanced real time quality control measures and these solutions will generate a significantly greater number of failure flags. To capitalise on the benefits that an improved quality control process can deliver, it will be important to ensure that an automation process is implemented simultaneously with enhanced, real time quality control measures and auto-verification of patient samples in middleware. Therefore, it appears that the best solution may be to automate those critical decisions that still require human intervention and therefore include quality control as an integral part of total laboratory automation.
Second-generation Elecsys cerebrospinal fluid immunoassays aid diagnosis of early Alzheimer’s disease
Authors: Blennow Kaj , Stomrud Erik , Zetterberg Henrik , Borlinghaus Niels , Corradini Veronika , Manuilova Ekaterina , Müller-Hübner Laura , Quevenco Frances-Catherine , Rutz Sandra , Hansson Oskar 
Published: October 2022

Abstract

Objectives
Timely diagnosis of Alzheimer’s disease (AD) is critical for appropriate treatment/patient management. Cerebrospinal fluid (CSF) biomarker analysis is often used to aid diagnosis. We assessed analytical performance of second-generation (Gen II) Elecsys® CSF immunoassays (Roche Diagnostics International Ltd), and adjusted existing cut-offs, to evaluate their potential utility in clinical routine.

Methods
Analytical performance was assessed using CSF samples measured with Elecsys CSF Gen II immunoassays on cobas e analyzers. Aβ42 Gen I/Gen II immunoassay method comparisons were performed (Passing-Bablok regression). Cut-off values were adjusted using estimated bias in biomarker levels between BioFINDER protocol aliquots/Gen I immunoassays and Gen II protocol aliquots/immunoassays. Distribution of Gen II immunoassay values was evaluated in AD, mild cognitive impairment (MCI), and cognitively normal cohorts; percentage observations outside the measuring range were derived.

Results
The Gen II immunoassays demonstrated good analytical performance, including repeatability, intermediate precision, lot-to-lot agreement (Pearson’s r: ≥0.999), and platform agreement (Pearson’s r: ≥0.995). Aβ42 Gen I/Gen II immunoassay measurements were strongly correlated (Pearson’s r: 0.985–0.999). Aβ42 Gen II immunoassay cut-offs were adjusted to 1,030 and 800 ng/L, and pTau181/Aβ42 ratio cut-offs to 0.023 and 0.029, for Gen II and I protocols, respectively. No observations were below the lower limit of the measuring range; above the upper limit, there were none from the AD cohort, and 2.6 and 6.8% from the MCI and cognitively normal cohorts, respectively.

Conclusions
Our findings suggest that the Gen II immunoassays have potential utility in clinical routine to aid diagnosis of AD.