bluuebunny/crossref_metadata_2025_split huggingface dataset:
Geschlechtsspezifische Unterschiede bei Herzinsuffizienz: Pathophysiologie,
Risikofaktoren und Bildgebung
Authors: Aßmus Birgit , Angermann Christiane E. 
Published: February 2022

ZusammenfassungHerzinsuffizienz betrifft etwa 4 Millionen Menschen in Deutschland, stellt die häufigste
Ursache für Hospitalisierungen dar und trägt wesentlich zur Morbidität und Letalität einer
älter werdenden Gesellschaft bei. Bei der Herzinsuffizienz gibt es ausgeprägte
geschlechtsspezifische Unterschiede, sowohl bezüglich Epidemiologie, Pathophysiologie und
Risikofaktoren als auch in der bildgebenden Diagnostik. Daher ist die Kenntnis der
Unterschiede zwischen Männern und Frauen mit Herzinsuffizienz in Hinblick auf die
genannten Faktoren essenziell sowohl für das Erkennen der Erkrankung als auch für
Interpretation der Diagnostik. Mit dem aktuellen Artikel wollen wir einen kurzen Überblick
zu geschlechtsspezifischen Unterschieden der Herzinsuffizienz-Entwicklung geben und zum
Weiterlesen inspirieren.
Synthesis of 5-Trifluoromethyl-Substituted (Z)-N,N-Dimethyl-N′-(pyrazin-2-yl)formimidamides from 2-Aminopyrazines, LiI/Selectfluor, FSO2CF2CO2Me and DMF under Cu Catalysis
Authors: Hu Jiao , Li Shengyu , Zheng Sheng-Cai , Zhao Xiaoming , Wang Xiaolin 
Published: February 2022

AbstractThe synthesis of 5-trifluoromethyl-substituted (Z)-N,N-dimethyl-N′-(pyrazin-2-yl)formimidamides via the iodination of 2-aminopyrazines with Selectfluor/LiI followed by a domino trifluoromethylation with FSO2CF2CO2Me and a condensation with DMF in the presence of CuI is realized under mild conditions. This three-step method offers CF3-substituted (Z)-N,N-dimethyl-N′-(pyrazin-2-yl)formimidamides in yields of 55–70% and with high regioselectivities. LiI serves as an iodine source, whilst DMF functions as both a solvent and a condensation reagent. The regioselectivity of these trifluoromethylation reactions is strongly dependent upon the substituent pattern on the 2-aminopyrazines. A possible mechanism for this method is also discussed.
Application of Proline-Derived (Thio)squaramide Organocatalysts in Asymmetric Diels–Alder and Conjugate Addition Reactions
Authors: Kupai József , Dargó Gyula , Nagy Sándor , Kis Dávid , Bagi Péter , Mátravölgyi Béla , Tóth Blanka , Huszthy Péter , Drahos László 
Published: February 2022

AbstractThe synthesis of chiral proline-derived squaramide and thiosquaramide organocatalysts, which are capable of the dual activation in asymmetric reactions is reported. The (thio)squaramide moiety can form hydrogen bonds to activate the substrates and to stereocontrol the reaction, while the pyrrolidine unit can form enamines to activate carbonyl compounds via aminocatalysis. Comparing the performance of thiosquaramide to squaramide, the Diels–Alder reaction of (anthracen-9-yl)acetaldehyde and trans-β-nitrostyrene was examined, which has been investigated in the literature using quantum chemical calculations. Both squaramide and thiosquaramide gave excellent yields (up to 99%) and enantiomeric excess values (up to 98%). Moreover, their catalytic performance was compared in conjugate addition of lawsone to β,γ-unsaturated α-keto ester.
Postural Control in Relapsing-Remitting Multiple Sclerosis
Authors: Cusin Flavia Salvaterra , Tomaz Andreza , Ganança Maurício Malavasi , Oliveira Enedina Maria , Gonçalves Alessandra Billi Falcão , Caovilla Heloisa Helena 
Published: February 2022

Abstract
Introduction Postural instability is considered one of the most disabling symptoms of relapsing-remitting multiple sclerosis (RRMS).
Objective To evaluate postural control in patients with RRMS.
Method A total of 79 individuals between 18 and 65 years old, of both genders, were distributed into an experimental group composed of patients with RRMS (n = 51) and in a control group composed by healthy individuals (n = 28). The evaluation consisted of anamnesis, Dizziness Handicap Inventory (DHI), visual vertigo analog scale (VVAS), and static posturography (Tetrax IBS).
Results Patients with RRMS presented mild degree in the DHI and in the VVAS; in Tetrax IBS, they presented higher or lower values of the indices of general stability, weight distribution, synchronization of postural oscillation, fall risk, and frequency bands of postural oscillation in two, five or all eight sensory conditions, in relation to the control group. Vestibular, visual and/or somatosensory dysfunction of peripheral type (51.0%) prevailed over the central type. The RRMS group, with an expanded scale of disability status > 3 points, presented a higher fall risk than with a score ≤ 3 points (p = 0.003). There was a positive correlation of the Fall Risk Index with the total DHI Score (s = 0.380; p = 0.006) and with the VVAS score (s = 0.348; p = 0.012).
Conclusion Patients with RRMS may present with inability to maintain postural control due to general instability, desynchronization and increased postural oscillation at frequencies that suggest deficiencies in the vestibular, visual, and somatosensory systems; as well as fall risk related to the state and intensity of functional disability and self-perception of the influence of dizziness on quality of life.
Resultados de uma técnica modificada de reconstrução assistida por artroscopia para instabilidade lateral do tornozelo
Authors: Sánchez Carlos A. , Briceño Ignacio , Robledo Jaime 
Published: February 2022

ResumoObjetivo O presente estudo avalia os resultados de uma técnica cirúrgica minimamente invasiva para o manejo da instabilidade aguda e crônica do tornozelo.Métodos O presente estudo de uma série de casos avaliou retrospectivamente 40 pacientes submetidos à reconstrução percutânea assistida por artroscopia do ligamento do tornozelo entre 2013 e 2019.Resultados O estudo incluiu 17 homens e 23 mulheres com idade média de 38,3 anos. O acompanhamento pós-intervenção utilizou a pontuação American Orthopaedic Foot and Ankle Society (AOFAS, na sigla em inglês). As pontuações do tornozelo-retropé identificaram melhora > 30 pontos na função e no controle da dor. As lesões associadas mais frequentes foram as osteocondrais (35%). Nenhum paciente precisou de reintervenção ou teve infecção durante o acompanhamento.Conclusão A técnica do presente estudo é fácil e consegue resultados satisfatórios para a função e o controle da dor.Nível de Evidência IV.
Incidence of Cardiovascular Events and Mortality in COVID-19 Patients Admitted in NIMS Intensive Care Unit during Second Wave
Authors: Srikanth N. , Jyotsna M. , Durga Padmaja , Kumar Achukatla 
Published: February 2022

Abstract
Prevalence of pulmonary thromboembolism (PTE) is very high when we compare the coronavirus disease 2019 positive patients with the other patients who are admitted in intensive care unit for other different infection. Thorough evaluation of the different causative factors for PTE should be better evaluated and prevention can be tried accordingly. Incidence of subclinical PTE that can give rise to future cardiac disease needs to be studied and plan of action can be done accordingly. Newer modalities of detecting PTE using non-invasive or simple invasive techniques need to be investigated to cope up in pandemic situation.
Main Complications during Pregnancy and Recommendations for Adequate Antenatal Care in Sickle Cell Disease: A Literature Review
Authors: Figueira Camilla Olivares , Surita Fernanda Garanhani , Fertrin Kleber , Nobrega Guilherme de Moraes , Costa Maria Laura 
Published: February 2022

AbstractSickle cell disease (SCD) is the most common monogenic disease worldwide, with a variable prevalence in each continent. A single nucleotide substitution leads to an amino-acid change in the β-globin chain, altering the normal structure ofhemoglobin, which is then called hemoglobin S inherited in homozygosity (HbSS) or double heterozygosity (HbSC, HbSβ), and leads to chronic hemolysis, vaso-occlusion, inflammation, and endothelium activation. Pregnant women with SCD are at a higher risk of developing maternal and perinatal complications. We performed a narrative review of the literature considering SCD and pregnancy, the main clinical and obstetrical complications, the specific antenatal care, and the follow-up for maternal and fetal surveillance. Pregnant women with SCD are at a higher risk of developing clinical and obstetric complications such as pain episodes, pulmonary complications, infections, thromboembolic events, preeclampsia, and maternal death. Their newborns are also at an increased risk of developing neonatal complications: fetal growth restriction, preterm birth, stillbirth. Severe complications can occur in patients of any genotype. We concluded that SCD is a high-risk condition that increases maternal and perinatal morbidity and mortality. A multidisciplinary approach during pregnancy and the postpartum period is key to adequately diagnose and treat complications.
Historical Clinical Outcomes of Children with Myelomeningocele Meeting the Criteria for Fetal Surgery: A Retrospective Cohort Survey of Brazilian Patients
Authors: Peixoto-Filho Fernando Maia , Cervante Tatiana Protzenko , Bellas Antonio Rosa , Gomes Junior Saint Clair , Lapa Denise Araújo , Acácio Gregório Lorenzo , Carvalho Paulo Roberto Nassar de , Sá Renato Augusto Moreira de 
Published: February 2022

Abstract
Objective To analyze the historical clinical outcomes of children with myelomeningocele (MMC) meeting the criteria for fetal surgery, but who underwent postnatal primary repair.
Methods Data from children undergoing postnatal MMC repair between January 1995 and January 2015 were collected from the Neurosurgery Outpatient Clinic's medical records. Children were included if they had ≥ 1 year of postoperative follow-up and met the criteria for fetal surgery. The children's data were then stratified according to whether they received a shunt or not. The primary outcome was mortality, and secondary outcomes were educational delays, hospitalization, recurrent urinary tract infections (UTIs), and renal failure.
Results Over the 20-year period, 231 children with MMC were followed up. Based on clinical data recorded at the time of birth, 165 (71.4%) qualify of fetal surgery. Of the 165 patients, 136 (82.4%) underwent shunt placement. The mortality rate was 5.1% in the group with shunt and 0% in the group without, relative risk (RR) 3.28 (95% confidence interval, 95% CI, 0.19–55.9). The statistically significant RRs for adverse outcomes in the shunted group were 1.86 (95% CI, 1.01–3.44) for UTI, 30 (95% CI, 1.01–537) for renal failure, and 1.77 (95% CI, 1.09–2.87) for hospitalizations.
Conclusion Children with MMC qualifying for fetal surgery who underwent shunt placement were more likely to have recurrent UTIs, develop renal failure, and be hospitalized. Since approximately half of the shunt procedures could be avoided by fetal surgery, there is a clinical benefit and a possible financial benefit to the implementation of this technology in our setting.
Characteristics of a Population with Gender Incongruence Assisted at a Specialized Outpatient Service in the City of Ribeirão Preto
Authors: Okano Sérgio Henrique Pires , Franceschini Silvio Antônio , Lerri Maria Rita , Poli-Neto Omero Benedicto , Brito Luiz Gustavo Oliveira , Lara Lúcia Alves da Silva 
Published: February 2022

Abstract
Objective To identify the age when individuals first perceive gender incongruence (GI) and to compare sociodemographic data of female-to-male (FtM) and male-to-female (MtF) transgender individuals assisted at an outpatient service.
Methods The present cross-sectional study was conducted through a review of the medical records of individuals diagnosed with GI at a single specialized outpatient service in the city of Ribeirão Preto, state of São Paulo, Brazil.
Results A total of 193 medical records from 2010 to 2018 were evaluated, and 109 (56.5%) patients had GI since childhood. The FtM transgender individuals perceived GI in childhood more often than the MtF transgender individuals (odds ratio [OR]: 2.06, 95% confidence interval [95%CI]: 1.11–3.81) Unattended hormone use was highest among the MtF group (69.6% versus 32.3%; OR: 4.78, 95%CI: 2.53–9.03). All of the individuals who were engaged in prostitution or were diagnosed with a sexually-transmitted infection, including HIV, were in the MtF group.
Conclusion Despite the more prevalent perception of GI in childhood among the FtM group, social issues were more prevalent among the MtF group, which may be the result of social marginalization.
Could Aspirin Treatment Modify the Assessment of the Uterine Arteries?
Authors: Vallejo Gabriela Marisol , Uriel Montserrat , Porras-Ramírez Alexandra , Romero Ximena Carolina 
Published: February 2022

Abstract
Objective To analyze whether acetylsalicylic (ASA) intake modifies the mean uterine arteries pulsatility index (UtA-PI) at the 2nd or 3rd trimester in a cohort of pregnant women with abnormal mean UtA-PI at between 11 and 14 weeks of gestation.
Methods This is a retrospective cohort study. Singleton pregnancies with abnormal mean UtA-PI at between 11 and 14 weeks of gestation were studied. The participants were divided into 3 groups: 1) If the participant did not take ASA during pregnancy; 2) If the participant took ASA before 14 weeks of gestation; and 3) If the participant took ASA after 14 weeks of gestation. The mean UtA-PI was evaluated at the 2nd and 3rd trimesters, and it was considered to improve when it decreased below the 95th percentile. The prevalence ratio (PR) and the number needed to treat (NNT) were calculated.
Results A total of 72 participants with a mean UtA-PI > 95th percentile at the 1st trimester of gestation were evaluated. Out of the 18 participants who took ASA, 8 participants started it before 14 weeks of gestation and 10 after. A total of 33.3% of these participants had improved the mean UtA-PI at the 2nd and 3rd trimesters of gestation, although it was not statistically significant (p = 0.154). The prevalence ratio was 0.95 (95% confidence interval [CI]: 0.31–1.89), but between the 1st and 2nd trimesters of gestation, the PR was 0.92 (95%CI: 0.21–0.99) and it was statistically significant.
Conclusion The present work demonstrates a modification of the mean UtA-PI in participants who took ASA compared with those who did not. It is important to check if ASA can modify the normal limits of uterine arteries because this could have an impact on surveillance.
Design and characteristic analysis of multi-degree-of-freedom ultrasonic motor based on spherical stator
Authors: Li Zheng , Guo Zhanyu , Han Haitao , Su Zhirong , Sun Hexu 
Published: February 2022

The multidimensional motion ultrasonic motor with a single spherical stator is studied in this paper. It has the characteristics of miniaturization and can be used in precision motion applications. By bonding six identical pieces of piezoelectric ceramic onto the stator and applying the voltage signal of high frequency, the deformation of the inverse piezoelectric effect is used to excite the stator yaw vibration mode. The orthogonal superposition of the modes of the spherical stator on the driving foot produces elliptical trajectory around X, Y, and Z directions by different excitation methods. According to the yaw vibration mode of the spherical stator, 12 driving feet are designed to drive the rotation of the spherical rotor. The structure and mechanical characteristics of the motor are simulated by using simulation software, and the transient response of the stator driving foot was obtained, which proved its feasibility. Finally, the output performance of the motor in actual operation is given through experiments, which provides a new reference scheme in the field of precise multi-degree-of-freedom motion. At a voltage of 100 V and a frequency of 26.7 kHz, the prototype has a no-load speed of 73, 70, and 114 rpm around X, Y, and Z axes, respectively.
Cotranslational interaction of human EBP50 and ezrin overcomes masked binding site during complex assembly
Authors: Khan Krishnendu , Long Briana , Baleanu-Gogonea Camelia , Gogonea Valentin , Deshpande Gauravi M. , Vasu Kommireddy , Fox Paul L. 
Published: February 2022

Significance
Multiprotein complexes in mammalian cells are thought to form by interactions between domains of mature, fully folded proteins. However, in some cases interprotein interaction is obstructed by “buried” or inaccessible binding domains. One such example is the interaction between EBP50 and ezrin, proteins linking the plasma membrane and cytoskeleton; self-association of domains in ezrin masks the site recognized by EBP50. Here, we show EBP50 overcomes this obstacle by cotranslationally binding to nascent ezrin’s otherwise masked domain emerging from the translating ribosome. Our study extends the function of mRNA translation beyond “simple” generation of linear peptide chains that fold into mature proteins for subsequent complex assembly; additionally, cotranslation can facilitate interactions with sterically inaccessible domains to form functional multiprotein complexes.
Damping of long wavelength gravitational waves by the intergalactic medium
Authors: Lieu Richard , Lackeos Kristen , Zhang Bing 
Published: February 2022

Abstract
The problem of radiation by the charged particles of the intergalactic medium (IGM) when a passing gravitational wave (GW) accelerates them is investigated. The largest acceleration (taking a charge from rest to a maximum speed which remains non-relativistic in the rest frame of the unperturbed spacetime) is found to be limited by the curvature of a propagating spherical gravitational wavefront. Interesting physics arises from the ensuing emission of radiation into the warm hot IGM, which to lowest order is a fully ionized hydrogen plasma with a frozen-in magnetic field B. It is found that for a vast majority of propagation directions, the radiation can penetrate the plasma at frequencies below the plasma frequency ω
p, provided ω < ω
b, where ω
b = eB/m
e satisfies ω
b < ω
p for typical IGM conditions. Moreover, the refractive index under such a scenario is n ≫ 1, resulting in an enhanced radiative dissipation of GW energy (relative to the vacuum scenario), which is more severe for electrons if both charge species are in thermal equilibrium and accelerated in the same way. The emission by the electrons then prevails, and is further amplified by coherent addition of amplitudes within the size one wavelength. The conversion of GWs of λ≳ 5 × 1013 cm to electromagnetic waves means such GWs can only propagate a distance ≲1 Gpc before being significantly damped by an IGM B field of ∼10−8 G. The low-frequency GWs targeted by pulsar-timing-arrays will not survive unless the IGM magnetic field is much lower than expected. The mHz frequency GW inspirals targeted by future space based detectors such as the Laser Interferometer Space Antenna remain intact and can be detected.
Quantum interference and domain–wall-like magnetic correlations in hexagonal graphene nanodisks
Authors: Hu Dong-Sheng , Ma Ling-Ling , Xiao Shi-Chang , Yu Shun-Li , Zhou Yuan 
Published: February 2022

Abstract
Quantum interference and traditional domain wall effects are two common ways to manipulate the magnetism in magnetic materials. Here, we report both effects emerge in the designed graphene nanodisks simultaneously, and thus providing an accessible way to engineer the magnetism in graphene nanostructures. By adjusting the length of the armchair edges at the corners of hexagonal disk, connecting the adjacent zigzag edges, we show that the quantum interference among the zigzag edges remains robust and consequently determines the magnetic structure in the small-size systems, in analogy with the nanoribbons. More importantly, a domain–wall-like magnetic mechanism is numerically identified to dominate the larger-size disks. In particular, a magnetic state with fully spin-polarized edges achieved in a wide parameter region promises the future applications for spintronics.
Manifestation of the Jahn–Teller effect subject to quadratic

T⊗e+t2

problem in ultrasonic attenuation. Case study of CaF2:Cr crystal with isovalent and aliovalent substitution
Authors: Sarychev Maksim N , Hosseny Wessam A L , Zhevstovskikh Irina V , Ulanov Vladimir A , Shakurov Gilman S , Egranov Aleksandr V , Surikov Vladimir T , Averkiev Nikita S , Gudkov Vladimir V 
Published: February 2022

Abstract
A new approach is introduced to obtain information about the adiabatic potential energy surface of the Jahn–Teller (JT) complexes subject to the

T
⊗

e
+

t

2

problem in doped crystals. It employs simulation of the contribution of the JT sub-system to ultrasonic attenuation with account of three mechanisms of relaxation and subsequent comparison with the experimental data on temperature dependence of the attenuation obtained with the use of doped crystal and nominally pure one. The approach has been applied to the CaF2 crystal doped with chromium. The experiment has been carried out at the frequencies of (13–158) × 106 Hz at low temperatures (4–170 K). Peak for all the ultrasonic normal modes propagating along the [110] axis has been observed at about 8 K. It has been considered as the JT effect manifestation by the sub-system of Cr2+

F

8

−

complexes. Symmetry properties of the global minima and saddle points have been identified, the JT stabilization energies and coordinates of the extrema points in the five-dimensional space of symmetrized displacements have been evaluated. Besides, a broad shoulder has been found at 15–40 K and attributed to contribution of the Cr3+

F

8

−

sub-system.
Hopfion dynamics in chiral magnets
Authors: Khodzhaev Zulfidin , Turgut Emrah 
Published: February 2022

Abstract
Resonant spin dynamics of topological spin textures are correlated with their topological nature, which can be employed to understand this nature. In this study, we present resonant spin dynamics of three-dimensional topological spin texture, i.e., Neel and Bloch hopfions. Using micromagnetic simulations, we stabilize Bloch and Neel hopfions with bulk and interfacial Dzyaloshinskii–Moriya interaction, respectively. We identify the ground state spin configuration of both hopfions, effects of anisotropies, geometric confinements, and demagnetizing fields. To confirm topological nature, Hopf number is calculated for each spin texture. Then, we calculate the resonance frequencies and spin-wave modes of spin precessions under multiple magnetic fields. Unique resonance frequencies and specific magnetic field dependence can help to guide experimental studies to identify the three-dimensional topological spin texture of hopfions in functioning chiral magnets when imaging is not possible.
Transport and structural properties of MgB2/Fe wires produced by redesigning internal Mg diffusion process
Authors: Yetiş Hakan , Avcı Doğan , Karaboğa Fırat , Aksoy Canan , Gajda Daniel , Martínez Elena , Tanyıldızı Fatih Mehmet , Zaleski Andrzej , Babij Michal , Tran Lan Maria , Angurel Luis Alberto , de la Fuente G F , Belenli İbrahim 
Published: February 2022

Abstract
We report transport, electromechanical, and structural properties of single core MgB2/Fe wire produced using a new fabrication method, called designed internal Mg diffusion (IMD) process, which relies on the use of non-stoichiometric Mg + B pellets with excess Mg in place of a central Mg rod used in the standard IMD method. Structural analysis revealed the successful formation of a porous MgB2 structure in the center and a dense circular MgB2 layer surrounding this structure in the designed-IMD wire. Fast transport I–V measurements showed that the designed IMD method increased engineering critical current density (J
e) up to twice that of the IMD wires in self-field. The central porous MgB2 structure shared the applied current and indirectly behaved as an internal stabilizer against quench damage at high applied currents.