bluuebunny/crossref_metadata_2025_split huggingface dataset:
The potential of Large Language Models for social robots in special education
Authors: Voultsiou Evdokia , Vrochidou Eleni , Moussiades Lefteris , Papakostas George A. 
Published: February 2025

Abstract
Large language models (LLMs) have created remarkable possibilities for analyzing and generating language data and have been integrated into several fields aiming to transform them, including education. While most research efforts focus on LLMs in typical education or social robots, limited applications of LLMs have been reported in special education. Moreover, there is a profound lack of combined research in LLM-based social robots in special education. In this work, we argue that although LLMs and social robots have demonstrated their potential to advance special education separately, their combination is not yet fully exploited, and further research is required to enable such use. The first objective of this work is to review relevant literature to assess the feasibility of developing LLMs on social robot platforms for use in special education. The second objective of this work is to reveal related challenges, limitations, opportunities, and ethical considerations to provide insights, aiming to subsequently formulate guidelines for the efficient integration of LLM-based social robots into special education practices. To this end, the third objective of this work is to propose a thoughtful framework, aiming to formulate a safe and inclusive learning environment for students in special education, suggesting actionable steps that could be followed by educators, developers and stakeholders, towards address the unique needs and challenges of students with diverse learning requirements.
What if there was a year 7–10 outdoor education curriculum in Victoria, Australia?
Authors: Ambrosy Josh , Quay John , Morse Marcus , Cox Matthew , Allen-Craig Sandy 
Published: February 2025

Abstract
There has been significant and sustained advocacy for a Year 7–10 Outdoor Education curriculum in Victoria and Australia for over forty years. Beginning in 2018, this prompted the formation of the Outdoor Education in the Victorian Curriculum (OEVC) project team, involving representatives from state-based professional associations: Outdoors Victoria, the Victorian branch of ACHPER (Australian Council for Health, Physical Education and Recreation), the Residential Outdoor Schools Association (ROSA), and Victorian universities with interests in Outdoor Education. The OEVC project has been formalised in recent years to focus on this vital work, consulting with teachers, administrators and academics in the drafting of a specific Year 7–10 Outdoor Education curriculum. To ascertain the perceived impact and appropriateness of a Year 7–10 Outdoor Education curriculum, teachers’ insights were solicited via an online survey, administered via statewide conferences of OE teachers convened separately by Outdoors Victoria, ACHPER Victoria, and ROSA. In this paper, we share the process surrounding the drafting of this Outdoor Education curriculum and the findings of the teacher survey. These findings suggest a Year 7–10 Outdoor Education curriculum in Victoria be seriously considered because it would support teachers and students who are already studying in this area in Years 7–10. Further, we suggest a possible solution might be to offer it as an option within the Health and Physical Education learning area in the Victorian Curriculum.
Roots of Resilience: Unraveling Yacouba Sawadogo’s Afrocentric Ecological Wisdom through Qualitative Inquiry
Authors: Sané Barwendé Médard 
Published: February 2025

Abstract
Through a personal mentoring relationship with Yacouba Sawadogo, the author analyzes his narrative, highlighting the roots of the climate crisis in the disconnection between humans and nature. The catastrophe epitomizes the visible manifestation of the invisible decay of “the interconnected relationships within creation (Zamane).” The author demonstrates how the Champion of the Earth advocates for a shift in mindset towards Mother Earth. Their qualitative inquiry includes interviews and narratives, examining Sawadogo’s Afrocentric ecological wisdom. In smelling his smell, the focus is on his resilience to provide a comprehension of individual ingenuity and community support, which are valuable for sustainable practices.
Uneven progress: Analyzing the factors behind digital technology adoption rates in Sub-Saharan Africa (SSA)
Authors: Astuti Hanim Maria , Ayinde Lateef Adeshina 
Published: February 2025

Abstract
Even though Sub-Saharan Africa (SSA) is lagging in digital technology adoption among the global average, there is substantial progress in terms of Information and Communication Technology (ICT) access and use, where it plays a crucial role in increasing the quality of life in the regions. However, digital gaps still exist within the continents, even though technology adoption across African nations has shown an increase in progress. This paper aims to explore factors that contribute to different adoption rates among three digital technologies in SSA, specifically mobile phones, fixed broadband, and fixed telephones. The methodology utilizes panel regression analysis to examine data sourced from the World Bank, which consists of 48 SSA countries from 2006 to 2022. The findings show a consistent growth in mobile phone subscriptions, different from fixed telephone and broadband internet that shows stagnant progress. Furthermore, infrastructure, and human capital are the most significant factors in addition to other influencing factors. The results of this study provide the African governments with insightful advice on addressing the digital divide and accelerating their digital transformation.
The Effects of Cultural Factors on Food Assistance After Disaster: A Scoping Review
Authors: Koçak Hüseyin , Karakuş Esma , Çalışkan Cüneyt , Dağ Nihal , Kınık Kerem , Güzel Aysun 
Published: February 2025

Abstract

Objective
The objective of this scoping review is to identify the cultural factors that influence the acceptance of food aid by those affected by disasters.

Methods
A literature review was conducted on articles published in Web of Science, Scopus, PubMed, Cochrane, and ScienceDirect databases until March 30, 2023, using keywords determined within the scope of the subject. This study follows the PICOS (participation, intervention, comparison, outcomes, study desings) and Preferred Reporting Items for Systematic reviews and Meta-Analyses extension for Scoping Reviews (PRISMA-ScR). Twelve articles that met the inclusion criteria were included in the findings.

Results
The study comprised 12 articles, of which 3 were cross-sectional, 5 were qualitative, 1 was descriptive, and 3 were mixed method studies. Thematic analysis identified 7 themes that emerged from the cultural factors/codes affecting nutrition activities in disasters: local and traditional food, socio-economic status, faith/religion, traditional practices and habits, cultural food beliefs and taboos, food sharing, and social organization.

Conclusions
A considerable body of research indicates that the selection of local and traditional foods is a key cultural factor influencing the efficacy of nutrition interventions and food assistance programs in the aftermath of disasters. It is therefore essential to take into account the identified cultural factors in order to ensure that the nutrition intervention is both accurate and efficient, and to enhance the acceptance of the population.
Diet, Glutathione S-Transferases M1 and T1 Gene Polymorphisms and Cancer Risk: A Systematic Review of Observational Studies
Authors: Karimi Elham , Abbasnezhad Shalaleh , Zeraattalab-Motlagh Sheida , Amiri Khosroshahi Reza , Beh-Afarin Seyed Reza , Mohammadi Hamed , Yaghmaie Marjan 
Published: February 2025

Abstract
Understanding the correlation between genes and diet holds significance in formulating tailored nutritional guidance and enhancing public health initiatives. Consequently, a thorough examination is undertaken to clarify the interplay between varying nutrient intake, Glutathione S-transferases Mu1 and Theta 1 (GSTM1 & T1) gene variants, and susceptibility to cancer development. In this study, we conducted a comprehensive search on MEDLINE/PubMed, Scopus, and Web of Science databases up to April 30, 2023. The review included observational studies that explored the relationship between dietary consumption of acrylamide, fruits, vegetables, plant-based foods, total meat, red meat, coffee, and green tea, as well as the presence of GSTM1 and T1 gene polymorphisms, and the risk of cancer in adult populations. The review findings indicated that high levels of risk factors, particularly red meat, have been linked to a higher chance of developing colorectal cancer risk among individuals with the GSTM1 null genotype. In contrast, heightened levels of protective factors, such as cruciferous vegetables, green tea, coffee, and fruit, have been associated with a decreased risk of lung cancer, adult leukemia, cutaneous melanoma, and lung cancer in individuals exhibiting GST polymorphisms. There is a scarcity of comprehensive studies examining different types of cancer due to various dietary patterns and genetic variations. Research has illuminated the complex interplay among dietary factors, gene polymorphisms, and cancer risk, further comprehensive studies are needed to understand and validate these findings fully. More robust investigations across diverse populations are crucial to developing personalized nutritional interventions and strengthening public health strategies.
‘Out-of-time’ Objects: Commemorating and Forgetting Traditions through Bronze Age Metalwork in Southern Britain
Authors: Knight Matthew G. 
Published: February 2025

Abstract
Earlier objects are frequently identified in later contexts, though rarely form the focus of discussion. This paper presents 34 sites where earlier Bronze Age metalwork has been found in later Bronze Age contexts in southern Britain, including hoards and non-hoard contexts. These ‘out-of-time’ objects follow complex trajectories and can inform us about the potential ways past societies conceived their own pasts, especially when contextualized in broader integrated landscapes. Out-of-time objects might be deposited singly or within hoards to reinforce community boundaries and legitimize links with past communities. The form, wear and treatment of these objects pre-deposition (e.g. curation and/or deformation) as well as the places in which they were buried represent indicators of prehistoric processes of commemoration and/or forgetting.
Mechanisms of Solute Transport in Ice‐Supersaturated Debris: 2. Rock Glacier Hydrology in Alpine Glacial‐Periglacial Systems
Authors: Seelig Simon , Seelig Magdalena , Krainer Karl , Winkler Gerfried 
Published: February 2025

AbstractActive rock glaciers represent permafrost‐affected aquifers that store freshwater in alpine headwater catchments. Groundwater flow in these aquifers is altered by degrading permafrost and the development of preferential flow paths in the subsurface. Where these pathways connect to form channel networks, they significantly change solute and pollutant transport. This study analyzes the hydraulic properties of such channel networks at two active rock glaciers in the Austrian Alps through tracer tests and inverse transport modeling. At both rock glaciers, tracer clouds traveling down the channel network show fast advection and limited dispersion. Parts of the tracer are retarded in stagnant water zones along the flow paths, such as turbulent eddies and vortices, recirculation in cascades and pools, and dead‐end passages between the blocks of the ice‐debris mixture forming the frozen rock glacier cores. The patterns of water infiltration control the channel network structure: localized recharge strongly concentrates flow along a major channel, diffuse recharge results in a distributed network of smaller channels with diverging and converging flow paths. The hydraulic properties of these channel networks are crucial for assessing the vulnerability of permafrost‐affected aquifers. They permit the rapid transfer and partial retardation of solutes, making them more susceptible to contamination—a growing concern as infrastructure development advances in high alpine environments.
Exploring the principles behind antibiotics with limited resistance
Authors: Maharramov Elvin , Czikkely Márton Simon , Szili Petra , Farkas Zoltán , Grézal Gábor , Daruka Lejla , Kurkó Eszter , Mészáros Léna , Daraba Andreea , Kovács Terézia , Bognár Bence , Juhász Szilvia , Papp Balázs , Lázár Viktória , Pál Csaba 
Published: February 2025

Abstract
Antibiotics that target multiple cellular functions are anticipated to be less prone to bacterial resistance. Here we hypothesize that while dual targeting is crucial, it is not sufficient in preventing resistance. Only those antibiotics that simultaneously target membrane integrity and block another cellular pathway display reduced resistance development. To test the hypothesis, we focus on three antibiotic candidates, POL7306, Tridecaptin M152-P3 and SCH79797, all of which fulfill the above criteria. Here we show that resistance evolution against these antibiotics is limited in ESKAPE pathogens, including Escherichia coli, Klebsiella pneumoniae, Acinetobacter baumannii and Pseudomonas aeruginosa, while dual-target topoisomerase antibiotics are prone to resistance. We discover several mechanisms restricting resistance. First, de novo mutations result in only a limited elevation in resistance, including those affecting the molecular targets and efflux pumps. Second, resistance is inaccessible through gene amplification. Third, functional metagenomics reveal that mobile resistance genes are rare in human gut, soil and clinical microbiomes. Finally, we detect rapid eradication of bacterial populations upon toxic exposure to membrane targeting antibiotics. We conclude that resistance mechanisms commonly found in natural bacterial pathogens provide only limited protection to these antibiotics. Our work provides guidelines for the future development of antibiotics.
Sub-femtomolar drug monitoring via co-calibration mechanism with nanoconfined DNA probes
Authors: Chen Yonghuan , Li Xiuying , Yue Xinru , Yu Weihua , Shi Yuesen , He Zilong , Wang Yuanfeng , Huang Yu , Xia Fan , Li Fengyu 
Published: February 2025

Abstract
Synthetic drugs fundamentally reshape the illicit drug market due to their low cost, ease of production, and rapid manufacturing processes. However, current drug detection methods, which rely on complex instruments, have limited applicability and often neglect the influence of pH fluctuations, leading to potential bias and unreliable results. Herein, we propose co-calibration DNA probes on a nanoconfined biosensor (NCBS), covering the range of sweat pH 3–8 to achieve significantly enhanced target signal recognition. The NCBS exhibits a linear response range of 103-108 fM with a low limit of detection (LOD) of 3.58 fM in artificial sweat. Compared to the single-aptamer NCBS, the dual-aptamer NCBS offers a broader linear response range, primarily due to the synergistic effects of changes in surface wettability and the capture of hydrion, which together reduce signal interference in proton transport. The linear response range doubles, and its detection sensitivity improves by 4–5 orders of magnitude compared to existing drug detection methods. This sensing strategy expands the application scope of aptamer-based composite probes, offering an approach for ultra-sensitive drug detection and demonstrating significant potential in sweat sensing and drug monitoring fields.
Intermediate-range solvent templating and counterion behaviour at charged carbon nanotube surfaces
Authors: Di Mino Camilla , Headen Thomas F. , Basma Nadir S. , Buckley David J. , Cullen Patrick L. , Wilding Martin C. , Shaffer Milo S. P. , Skipper Neal T. , Clancy Adam J. , Howard Christopher A. 
Published: February 2025

Abstract
The ordering of ions and solvent molecules around nanostructures is of profound fundamental importance, from understanding biological processes to the manipulation of nanomaterials to optimizing electrochemical devices. Classical models commonly used to describe these systems treat the solvent simplistically, an approach that endures, in part, due to the extreme difficulty of attaining experimental measurements that challenge this approximation. Here we perform total neutron scattering experiments on model systems—concentrated amide solutions of negatively charged carbon nanotubes and sodium counterions—and measure remarkably complex intermediate-range molecular solvent ordering. The charged surface orders the solvents up to ∼40 Å, even beyond its dense concentric solvation shells. Notably, the molecular orientation of solvent in direct contact with the nanotube surface itself is distinct, lying near-parallel and not interacting with desolvated sodium counterions. In contrast, beyond this layer the ordering of solvent is perpendicular to the surface. Our results underscore the critical importance of multibody interactions in solvated nanoscale systems and charged surfaces, highlighting competing ion/surface solvation effects.
Perinatal obesity primes the hepatic metabolic stress response in the offspring across life span
Authors: Stegmann Sarah K , Vohlen Christina , Im Nam Gyu , Niehues Jana , Selle Jaco , Janoschek Ruth , Kuiper-Makris Celien , Lang Sonja , Demir Münevver , Steffen Hans-Michael , Quaas Alexander , Lackmann Jan-Wilm , Nierhoff Dirk , Neumann-Haefelin Christoph , Dötsch Jörg , Alejandre Alcazar Miguel A , Kasper Philipp 
Published: February 2025

Abstract
Perinatal obesity is associated with an increased risk of metabolic diseases and hepatic dysfunction in offspring. However, the underlying mechanisms of this metabolic programming remain incompletely understood. This study aimed to elucidate the influence of maternal obesity and early life exposure to high-fat diet on offspring liver phenotype, hepatokine profile, and key components of hepatic metabolism. To this end, we employed a murine high-fat diet-induced perinatal obesity model, investigating the offspring in early life and late adulthood. After exposure to perinatal obesity, the offspring showed a significantly increased body weight in early life with no histological signs of steatosis, but a dysregulated hepatokine profile. Proteomic profiling, followed by molecular analyses, revealed a decreased lipogenesis and increased fatty acid oxidation, suggesting a protective mechanism against the development of steatosis. These changes were accompanied by increased markers of lipid peroxidation and DNA damage, indicating increased oxidative stress. Concomitantly, the antioxidative enzymes catalase and superoxide dismutase 2 were significantly reduced and oxidative phosphorylation was impaired, implying an altered oxidative stress response. While changes in oxidative stress level were only detected in early life, the lipid metabolism was altered across life span. This metabolic programming could determine the resilience and susceptibility to chronic liver disease later in life.
Optimizing spatial normalization of multisubject inner ear MRI: comparison of different geometry-preserving co-registration approaches
Authors: Gerb Johannes , Kirsch Valerie , Kierig Emilie , Brandt Thomas , Dieterich Marianne , Boegle Rainer 
Published: February 2025

Abstract
Spatial normalization of multisubject inner ear imaging data is challenging, due to both substantial intraindividual differences and the small size of the organ compared to other intracranial structures. Automatic whole brain co-registration to standard space can only roughly co-align the peripheral vestibular endorgan, and complemental manual registration is highly time-consuming. Here, we compared the accuracy of four geometry-maintaining co-registration methods (one semi-manual method and three automatic methods). High-resolution structural T2-MRI of 153 inner ears from patients and healthy participants were co-registered to an inner-ear atlas. The semi-manual method used a three-point landmark-based approach (3P), two automatic methods were based on unassisted standard algorithms (Advanced Normalization Tools (ANTs), Elastix (EL)), while the fourth automatic method utilized a volumetrically dilated, atlas-based mask (thick inner ear, TIE) for probabilistic inner ear masking. Registration accuracy was evaluated by neurotologists blinded to the respective registration paradigm, and the resulting median volumes were quantified using colocalization analyses. The mask-aided automatic approach showed the best ratings, followed by the semi-manual three-point landmark-based registration (mean ratings (lower: better) TIE 2.21 ± 1.15; 3P 2.58 ± 0.61; EL 3.42 ± 1.06; ANTs 3.49 ± 1.26). The semi-manual method had the lowest rate of insufficient registrations, followed by TIE (3P: 3.70%; TIE: 8.28%; EL: 22.66%; ANTs: 27.02%). TIE showed the highest colocalization metrics with the atlas. Only TIE and 3P allowed for sufficient semicircular canal visualization in method-wise average volumes. Overall, geometry-preserving spatial normalization of multisubject inner ear imaging data is possible and could allow groupwise examinations of the bony labyrinth or temporal bone morphology in the future.
Different Ras isoforms regulate synaptic plasticity in opposite directions
Authors: López-Merino Esperanza , Fernández-Rodrigo Alba , Jiang Jessie G , Gutiérrez-Eisman Silvia , Fernández de Sevilla David , Fernández-Medarde Alberto , Santos Eugenio , Guerra Carmen , Barbacid Mariano , Esteban José A , Briz Víctor 
Published: February 2025

Abstract
The small GTPase Ras is an intracellular signaling hub required for long-term potentiation (LTP) in the hippocampus and for memory formation. Genetic alterations in Ras signaling (i.e., RASopathies) are linked to cognitive disorders in humans. However, it remains unclear how Ras controls synaptic plasticity, and whether different Ras isoforms play overlapping or distinct roles in neurons. Using genetically modified mice, we show here that H-Ras (the most abundant isoform in the brain) does not promote LTP, but instead long-term depression mediated by metabotropic glutamate receptors (mGluR-LTD). Mechanistically, H-Ras is activated locally in spines during mGluR-LTD via c-Src, and is required to trigger Erk activation and de novo protein synthesis. Furthermore, H-Ras deletion impairs object recognition as well as social and spatial memory. Conversely, K-Ras is the isoform specifically required for LTP. This functional specialization correlates with a differential synaptic distribution of the two isoforms H-Ras and K-Ras, which may have important implications for RASopathies and cognitive function.
Robustness and uniqueness of equilibrium states for certain partially hyperbolic systems*
Authors: Mongez Juan Carlos , Pacifico Maria José 
Published: February 2025

Abstract
We prove that if f is a

C

1
+

partially hyperbolic diffeomorphism satisfying certain conditions then there is a C
1-open neighborhood

A

of f so that every

g
∈

A

∩

Diff

1
+

⁡
(
M
)

has a unique equilibrium state.