bluuebunny/crossref_metadata_2025_split huggingface dataset:
Diagnosis, prevention and treatment of common shoulder injuries in sport: grading the evidence – a statement paper commissioned by the Danish Society of Sports Physical Therapy (DSSF)
Authors: Liaghat Behnam , Pedersen Julie Rønne , Husted Rasmus Skov , Pedersen Lisbeth Lund , Thorborg Kristian , Juhl Carsten B 
Published: October 2022

This statement paper summarises and appraises the evidence on diagnosis, prevention, and treatment of common shoulder injuries in sports. We systematically searched Medline and Embase. The Grading of Recommendations Assessment, Development and Evaluation tool was applied to evaluate the overall quality of evidence.For diagnosis, we included 19 clinical tests from mixed populations. Tests for anterior instability, biceps-labrum complex injuries and full subscapularis rupture had high diagnostic accuracy (low to moderate quality of evidence).For prevention, the Oslo Sports Trauma Research Center, the Shoulder Control, the FIFA 11+ shoulder injury prevention programmes, and a baseball-specific programme (range of motion, stretching, dynamic stability and strengthening exercises) showed moderate to large effect size in reducing the risk of shoulder injury compared with no intervention (very low to moderate quality of evidence).For treatment, a rehabilitation programme including stretching, ice packs, electrotherapy and compression, and strengthening exercises showed a large effect size in reducing pain and disability compared with no intervention in athletes with subacromial impingement syndrome (very low to moderate quality of evidence). For the treatment of supraspinatus tendinopathy, hyperthermia treatment (heating the skin to 38°C–40°C) resulted in large effect size in reducing pain and disability compared with ultrasound or pendular swinging and stretching exercises (moderate quality of evidence). Strengthening exercise alone or in combination with stretching exercises promoted a large effect in reducing shoulder pain (cohort studies, no comparators) (very low quality of evidence). The quality of evidence for most estimates was low to moderate, indicating that future high-quality research may alter our recommendations for clinical practice.
Association between recovery/occurrence of metabolic syndrome and rapid estimated glomerular filtration rate decline in middle-aged and older populations: evidence from the China Health and Retirement Longitudinal Study
Authors: Liu Peijia , Tang Leile , Fang Jia , Chen Chaojin , Liu Xun 
Published: October 2022

ObjectivesFew studies have explored correlations between metabolic syndrome (MetS) alterations and renal deterioration in longitudinal cohorts. We aim to investigate associations between MetS recovery/development and rapid estimated glomerular filtration rate (eGFR) decline in the China Health and Retirement Longitudinal Study (CHARLS).DesignLongitudinal cohort study.SettingThis study is a secondary analysis of CHARLS.ParticipantsAfter excluding individuals with age <45 years old, eGFR <60 mL/min/1.73 m2and clinician-reported malignant tumour, heart disease, stroke or kidney disease at baseline, 4142 participants with complete data were selected from the CHARLS during the 4-year follow-up period (2011–2015).Outcome measuresMetS were measured at 2011 and 2015 in CHARLS. A rapid eGFR decline was defined as an average annual eGFR decline of >3 mL/min/1.73 m2. The associations between rapid eGFR decline and MetS recovery/development were analysed using multivariable adjusted logistic models.ResultsAccording to MetS baseline status and follow-up, participants were divided into four groups: (1) 2460 (59.4%) in the MetS-free group, (2) 361 (8.7%) in the MetS-developed group, (3) 499 (12.0%) in the MetS recovery group and (4) 822 (19.8%) in the MetS chronic group. When compared with the MetS chronic group, the multivariable adjusted OR of rapid eGFR decline in the MetS recovery group was 0.64 (OR: 0.64; 95% CI 0.45 to 0.90, p=0.01). In contrast, when compared with the MetS-free group, the multivariable adjusted OR of rapid eGFR decline in the MetS-developed group was 1.00 (OR: 1.00; 95% CI 0.73 to 1.38, p=0.98).ConclusionsOver the 4-year follow-up period, we found that MetS recovery was associated with a reduced risk of rapid eGFR decline in middle-aged and older adults, while MetS occurrence was not related to rapid eGFR decline. Recovery from MetS appeared to protect against a rapid decline in eGFR.
Mediation role of work motivation and job satisfaction between work-related basic need satisfaction and work engagement among doctors in China: a cross-sectional study
Authors: Xu Le , Wang Zhonghua , Li Zhong , Lin Yuxin , Wang Juanjuan , Wu Yang , Tang Jinhai 
Published: October 2022

ObjectivesThis study aims to examine the association of work-related basic need satisfaction (W-BNS) with doctors’ work engagement and explore the mediating role of work motivation and job satisfaction between the two variables.DesignThis was a cross-sectional study.SettingThe study was conducted in four public grade A tertiary hospitals in China.ParticipantsA total of 1000 doctors were invited to participate; 849 doctors completed questionnaires validly.Primary and secondary outcome measuresQuestionnaires were administered online and offline to collect data, consisting of six parts: social demographic characteristics, work-related characteristics, and scales related to W-BNS, work motivation, job satisfaction and work engagement. One-way analysis of variance, Pearson correlation analysis were performed using SPSS, and mediation analysis was carried out via PROCESS macro.ResultsOur research showed that W-BNS, work motivation, job satisfaction and work engagement were positively correlated. Work engagement was significantly predicted by W-BNS (β＝0.15, p<0.001) through motivation at work (β＝0.23, p<0.001) and job satisfaction (β＝0.44, p<0.001), respectively. Compared with work motivation, the mediating effect of job satisfaction was stronger (95% CI −0.22 to −0.06).ConclusionThe findings suggest that job satisfaction and work motivation may be important pathways through which doctors’ W-BNS may influence their work engagement. In order to maintain and promote doctors’ work engagement, hospital administrators should consider strengthening the internal motivation of doctors and improving their job satisfaction.
Choice and Partnership Approach to community mental health and addiction services: a realist-informed scoping review
Authors: Campbell Leslie Anne , Clark Sharon E , Chorney Jill , Emberly Debbie , MacDonald Julie , MacKenzie Adrian , Warner Grace , Wozney Lori 
Published: October 2022

ObjectivesThe Choice and Partnership Approach (CAPA) was developed to create an accessible, child-centred and family-centred model of child and adolescent mental health service delivery that is adaptable to different settings. We sought to describe the state of evidence regarding the extent, outcomes and contextual considerations of CAPA implementation in community mental health services.DesignScoping review.Data sourcesPublished and grey literature were searched using MEDLINE, Embase, CINAHL, PsycINFO, Scopus and Google to 13 and 20 July 2022, respectively.Eligibility criteriaWe included reports focused on the implementation, outcomes (clinical, programme or system) or a discussion of contextual factors that may impact CAPA implementation in either child and adolescent or adult mental health services.Data extraction and synthesisData were extracted using a codebook that reflected the five domains of the Consolidated Framework for Implementation Research (CFIR) and reviewed for agreement and accuracy. Data were synthesised according to the five CFIR domains.ResultsForty-eight reports describing 36 unique evaluations were included. Evaluations were observational in nature; 10 employed pre–post designs. CAPA implementation, regardless of setting, was largely motivated by long wait times. Characteristics of individuals (eg, staff buy-in or skills) were not reported. Processes of implementation included facilitative leadership, data-informed planning and monitoring and CAPA training. Fidelity to CAPA was infrequently measured (n=9/36) despite available tools. Health system outcomes were most frequently reported (n=28/36); few evaluations (n=7/36) reported clinical outcomes, with only three reporting pre/post CAPA changes.ConclusionsGaps in evidence preclude a systematic review and meta-analysis of CAPA implementation. Measurement of clinical outcomes represents an area for significant improvement in evaluation. Consistent measurement of model fidelity is essential for ensuring the accuracy of outcomes attributed to its implementation. An understanding of the change processes necessary to support implementation would be strengthened by more comprehensive consideration of contextual factors.
What the children tell us: the COVID-19 pandemic and how the world should respond
Authors: Kyeremateng Rosina , Lynch Margaret A , Pinzón-Segura María Camila , Osei-Bonsu Angela , Fortmann Joshua , Wood David 
Published: October 2022

While the COVID-19 pandemic and associated mitigation measures have had a devastating impact on children and youth (CY), they were rarely consulted or their views incorporated into the approaches to address the pandemic.The main objective of this review is to present the voices and opinions of CY relative to the impact of the first year of the pandemic, on their lives and the lives of their families, and to present their recommendations as a call to action to adults and governments.The origin of this review was an iterative consultation process involving an international collective of Child Health professionals specialising in Child Rights. The recruitment of articles began by soliciting articles written or recommended by members of our international Child Health professional organisation. We then developed search strategies which were conducted in two phases, with the assistance of medical librarians. We limited our search to articles that sought the direct perspectives and experiences of CY in regard to the first year of COVID-19, and published between February 2020 and February 2021.Two phases of searches identified 8131 studies for screening. Following removal of irrelevant literature, 28 studies were included for the final analysis.CY articulate the detrimental impact of the COVID-19 pandemic to their health, education, protection and basic needs, clearly and intelligently. They make specific recommendations to address the issues they elucidate. They state a need for accurate information that is targeted for them. They ask for recognition as stakeholders and social actors in the pandemic response planning and implementation processes.We assert that the recognition of CY as stakeholders in response planning for COVID-19 and other emerging crises such as climate change, must become a statutory requirement for local, national and international policy-makers. Evidence of CY participation should specifically be reported to and tracked by the Committee on the Rights of the Child.
Post-wildfire salvage logging effects on snag structure and dead woody fuel loadings
Authors: Johnson Morris C. , Kennedy Maureen C. , Harrison Sarah C. , Alvarado Ernesto , Desautel Cody , Holford Joseph , Logue Shay 
Published: October 2022

Salvage logging is a controversial tool for post-wildfire management that removes fire-killed trees. We use a generalized randomized experimental design to fulfill two main objectives: (1) quantify the immediate (1-year post-harvest) effects of salvage logging on stand structure, fine and coarse woody fuel loadings; and (2) use pre- and post-empirical field data and the Fire and Fuels Extension to the Forest Vegetation Simulator (Reinhardt and Crookston 2003) to simulate post-wildfire dead woody fuel succession and snag dynamics. We compared the effects on woody fuel loadings of two salvage logging prescriptions: (1) seed tree harvest, thin to 3.4 m2·ha−1; and (2) full salvage of all merchantable timber, relative to unlogged controls. There was substantial block-level variability in the implementation of the treatments and in their immediate effects on fine fuel loading, complicating comparison of the two prescriptions. Overall, salvage logging did reduce snag basal area and, relative to unlogged controls, significantly increased measured fine woody fuel loading (10 and 100 h). Simulated snag fall was rapid, with a mean predicted snag basal area loss of 61% within 10 years. Future long-term monitoring of permanent field plots will supplement model predictions and provide valuable data to inform post-wildfire management decisions.
Diffractive semi-hard production of a $$J/\psi $$ or a $$\Upsilon $$ from single-parton fragmentation plus a jet in hybrid factorization
Authors: Celiberto Francesco Giovanni , Fucilla Michael 
Published: October 2022

AbstractWe investigate the inclusive hadroproduction of a heavy quarkonium ($$J/\psi $$

J
/
ψ

or $$\Upsilon $$
Υ
), in association with a light-flavored jet, as a testing ground for the semi-hard regime of QCD. Our theoretical setup is the hybrid high-energy and collinear factorization, where the standard collinear approach is supplemented by the t-channel resummation of leading and next-to-leading energy logarithms à la BFKL. We present predictions for rapidity and azimuthal-angle differential distributions, hunting for stabilizing effects of the high-energy series under higher-order corrections. Our reaction represents an additional channel to test the production mechanisms of quarkonia at high energies and large transverse momenta and to possibly shed light on the transition region from heavy-quark pair production to single-parton fragmentation of $$J/\psi $$

J
/
ψ

and $$\Upsilon $$
Υ
states.
Displaced vertex and disappearing track signatures in type-III seesaw
Authors: Jana Sudip , Okada Nobuchika , Raut Digesh 
Published: October 2022

AbstractWe investigate a prospect of probing the type-III seesaw neutrino mass generation mechanism at various collider experiments by searching for a disappearing track and a displaced vertex signature originating from the decay of $$SU(2)_L$$

S
U

(
2
)

L

triplet fermion ($$\Sigma $$
Σ
). Since $$\Sigma $$
Σ
is primarily produced at colliders through the electroweak gauge interactions, its production rate is uniquely determined by its mass. We find that a $$\Sigma $$
Σ
particle produces a disappearing track signature from the decay of its charged component, which can be searched at the HL-LHC. Furthermore, we show that if the lightest observed neutrino has a mass of around $$10^{-9}$$

10

-
9

eV, the neutral component of $${\Sigma }$$
Σ
can be discovered at the proposed MATHUSLA detector. We also show that the charged component of $${\Sigma }$$
Σ
can be potentially be observed at FCC-he as a displaced vertex signature.
MORPHOLOGICAL MEASURES OF SCAPULA IN SOUTH INDIAN POPULATION USING CT
Authors: Jaseemudheen M. M. , Dkhar Winniecia , Sharma Dolly 
Published: October 2022

Introduction: An immense knowledge about the shape of the glenoid cavity is necessary for TSA. This study aims to evaluate the dimension of the glenoid cavity and to compare the morphological measures of scapula between genders. Materials and methods: A total of 32 males and 32 females were selected for the shoulder scan and the measurements were taken in 2D axial plane and 3D reconstructed images. Statistical analysis was done using SPSS Version 21.0. [Formula: see text] 0.05 was taken as significant. Result: Out of five diameters that we considered in this study, the superior–inferior (SI) mean glenoid diameter is 33.09 ± 3.82 mm. The anterior–posterior average glenoid diameters AP1, AP2, AP3 and AP4 are 15.08 ± 3.03 mm, 18.12 ± 3.26 mm, 21.03 ± 2.41 mm, 22.1 ± 2.54 mm, respectively, in total population. Six angles were considered, the Axis of glenoid, Axis of scapula, Axis of humeral head, axis of the glenoid neck, Resch angle and version of glenoid, measured 132.51[Formula: see text]± 5.46[Formula: see text], 43.03[Formula: see text]± 5.04[Formula: see text], 132.44[Formula: see text]± 5.04[Formula: see text], 58.48[Formula: see text]± 6.42[Formula: see text], 72.92[Formula: see text]± 4.79[Formula: see text], − 5.21[Formula: see text]± 1.45[Formula: see text], respectively, for the total population. The specific cut-off points for SI, AP1, AP2, AP3 and AP4 are 35, 15.35, 18.1, 21.55 and 22.65, respectively. Conclusion: The morphological measures such as Axis of glenoid, Axis of humeral head, Resch angle and Axis of scapula show that there exists a statistically significant difference between two genders. Hence, these four measures have a vital role in gender identification of an unknown scapula. All the diameters in this study have got specific cut-off points and it will be most useful to discriminate the gender from an unknown scapula.
Identifying the Transcriptional Drivers of Metastasis Embedded within Localized Melanoma
Authors: Suresh Shruthy , Rabbie Roy , Garg Manik , Lumaquin Dianne , Huang Ting-Hsiang , Montal Emily , Ma Yilun , Cruz Nelly M , Tang Xinran , Nsengimana Jérémie , Newton-Bishop Julia , Hunter Miranda V. , Zhu Yuxin , Chen Kevin , de Stanchina Elisa , Adams David J. , White Richard M. 
Published: October 2022

Abstract

In melanoma, predicting which tumors will ultimately metastasize guides treatment decisions. Transcriptional signatures of primary tumors have been utilized to predict metastasis, but which among these are driver or passenger events remains unclear. We used data from the adjuvant AVAST-M trial to identify a predictive gene signature in localized tumors that ultimately metastasized. Using a zebrafish model of primary melanoma, we interrogated the top genes from the AVAST-M signature in vivo. This identified GRAMD1B, a cholesterol transfer protein, as a bona fide metastasis suppressor, with a majority of knockout animals rapidly developing metastasis. Mechanistically, excess free cholesterol or its metabolite 27-hydroxycholesterol promotes invasiveness via activation of an AP-1 program, which is associated with increased metastasis in humans. Our data demonstrate that the transcriptional seeds of metastasis are embedded within localized tumors, suggesting that early targeting of these programs can be used to prevent metastatic relapse.

Significance:
We analyzed human melanoma transcriptomics data to identify a gene signature predictive of metastasis. To rapidly test clinical signatures, we built a genetic metastasis platform in adult zebrafish and identified GRAMD1B as a suppressor of melanoma metastasis. GRAMD1B-associated cholesterol overload activates an AP-1 program to promote melanoma invasion.
This article is highlighted in the In This Issue feature, p. 1
VISTA Targeting of T-cell Quiescence and Myeloid Suppression Overcomes Adaptive Resistance
Authors: Schaafsma Evelien , Croteau Walburga , ElTanbouly Mohamed , Nowak Elizabeth C. , Smits Nicole C. , Deng Jie , Sarde Aurelien , Webber Cecilia A. , Rabadi Dina , Cheng Chao , Noelle Randolph , Lines J. Louise 
Published: October 2022

Abstract

V domain immunoglobulin suppressor of T-cell activation (VISTA) is a premier target for cancer treatment due to its broad expression in many cancer types and enhanced expression upon development of adaptive immune checkpoint resistance. In the CT26 colorectal cancer model, monotherapy of small tumors with anti-VISTA resulted in slowed tumor growth. In a combination therapy setting, large CT26 tumors showed complete adaptive resistance to anti–PD-1/CTLA-4, but inclusion of anti-VISTA led to rejection of half the tumors. Mechanisms of enhanced antitumor immunity were investigated using single-cell RNA sequencing (scRNA-seq), multiplex image analysis, and flow cytometry of the tumor immune infiltrate. In both treatment models, anti-VISTA upregulated stimulated antigen presentation pathways and reduced myeloid-mediated suppression. Imaging revealed an anti-VISTA stimulated increase in contacts between T cells and myeloid cells, further supporting the notion of increased antigen presentation. scRNA-seq of tumor-specific CD8+ T cells revealed that anti-VISTA therapy induced T-cell pathways highly distinct from and complementary to those induced by anti–PD-1 therapy. Whereas anti–CTLA-4/PD-1 expanded progenitor exhausted CD8+ T-cell subsets, anti-VISTA promoted costimulatory genes and reduced regulators of T-cell quiescence. Notably, this is the first report of a checkpoint regulator impacting CD8+ T-cell quiescence, and the first indication that quiescence may be a target in the context of T-cell exhaustion and in cancer. This study builds a foundation for all future studies on the role of anti-VISTA in the development of antitumor immunity and provides important mechanistic insights that strongly support use of anti-VISTA to overcome the adaptive resistance seen in contemporary treatments involving PD-1 and/or CTLA-4.
See related Spotlight by Wei, p. 3
Religious Coping and Depressive Symptoms among Religious Belgian Hospitalized Patients: The Mediating Role of Hope
Authors: Buelens Eva , Dezutter Jessie , Vandenhoeck Anne , Dillen Annemie 
Published: October 2022

Abstract
Research on the pathways through which positive/negative religious coping (PRC/NRC) styles work, is sparse. This cross-sectional study examined hope as a mediating pathway in the association between PRC/NRC and depressive symptoms in 155 hospital inpatients in Belgium that self-reported to be religious (mostly Catholic, Christian or religious without affiliation to a religious institute). Patients relying more on NRC tend to have more depressive symptoms through the mechanism of hope. Interestingly, the direct relationship found between NRC and depressive symptoms points to the likelihood of an omitted mediator requiring further research. Patients more often using PRC tend to have fewer depressive symptoms through the mechanism of hope. No direct relationship between PRC and depressive symptoms was found.
Spiritual Awakening among Church Members during the Pandemic: An Empirical Study in England and Wales
Authors: Francis Leslie J. , Village Andrew , Lewis Christopher Alan 
Published: October 2022

Abstract
For some church members the pandemic may have been a challenge to faith, while for others the pandemic may have been an opportunity to re-kindle faith and to trigger spiritual awakening. A sample of 3,673 churchgoers (Anglican and Catholic) completed an online survey during the early months of the lockdown including the Lewis Index of Spiritual Awakening (LISA). The data demonstrated that more participants experienced a sense of spiritual awakening than a spiritual decline. Spiritual awakening was associated with personal factors (being female and older), with psychological factors (feeling types, intuitive types, and emotional stability), with religious identity (being Catholic), with theological tradition (being charismatic and conservative), and with active engagement in online services (lighting candles or typing in prayer requests). Experiencing spiritual awakening during the early months of the lockdown is, thus, associated with religious, theological, and spiritual practices, as well as with personal and psychological factors.