bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bax Contributes to Retinal Ganglion Cell Dendritic Degeneration During Glaucoma
Authors: Risner Michael L. , Pasini Silvia , McGrady Nolan R. , Calkins David J. 
Published: January 2022

AbstractThe BCL-2 (B-cell lymphoma-2) family of proteins contributes to mitochondrial-based apoptosis in models of neurodegeneration, including glaucomatous optic neuropathy (glaucoma), which degrades the retinal ganglion cell (RGC) axonal projection to the visual brain. Glaucoma is commonly associated with increased sensitivity to intraocular pressure (IOP) and involves a proximal program that leads to RGC dendritic pruning and a distal program that underlies axonopathy in the optic projection. While genetic deletion of the Bcl2-associated X protein (Bax-/-) prolongs RGC body survival in models of glaucoma and optic nerve trauma, axonopathy persists, thus raising the question of whether dendrites and the RGC light response are protected. Here, we used an inducible model of glaucoma in Bax-/- mice to determine if Bax contributes to RGC dendritic degeneration. We performed whole-cell recordings and dye filling in RGCs signaling light onset (αON-Sustained) and offset (αOFF-Sustained). We recovered RGC dendritic morphologies by confocal microscopy and analyzed dendritic arbor complexity and size. Additionally, we assessed RGC axon function by measuring anterograde axon transport of cholera toxin subunit B to the superior colliculus and behavioral spatial frequency threshold (i.e., spatial acuity). We found 1 month of IOP elevation did not cause significant RGC death in either WT or Bax-/- retinas. However, IOP elevation reduced dendritic arbor complexity of WT αON-Sustained and αOFF-Sustained RGCs. In the absence of Bax, αON- and αOFF-Sustained RGC dendritic arbors remained intact following IOP elevation. In addition to dendrites, neuroprotection by Bax-/- generalized to αON-and αOFF-Sustained RGC light- and current-evoked responses. Both anterograde axon transport and spatial acuity declined during IOP elevation in WT and Bax-/- mice. Collectively, our results indicate Bax contributes to RGC dendritic degeneration and distinguishes the proximal and distal neurodegenerative programs involved during the progression of glaucoma.
Variations in length of stay among survived very preterm infants admitted to Chinese neonatal intensive care units
Authors: Zhang Min , Wang Yan-Chen , Feng Jin-Xing , Yu Ai-Zhen , Huang Jing-Wei , Jiang Si-Yuan , Gu Xin-Yue , Sun Jian-Hua , Cao Yun , Zhou Wen-Hao , Lee Shoo K. , Wang Li-Li , Yin Rong ,   Chinese Neonatal Network
Published: January 2022

AbstractBackgroundThis study aimed to describe length of stay (LOS) to discharge and site variations among very preterm infants (VPIs) admitted to 57 Chinese neonatal intensive care units (NICUs) and to investigate factors associated with LOS for VPIs.MethodsThis retrospective multicenter cohort study enrolled all infants < 32 weeks’ gestation and admitted to 57 NICUs which had participated in the Chinese Neonatal Network, within 7 days after birth in 2019. Exclusion criteria included major congenital anomalies, NICU deaths, discharge against medical advice, transfer to non-participating hospitals, and missing discharge date. Two multivariable linear models were used to estimate the association of infant characteristics and LOS.ResultsA total of 6580 infants were included in our study. The overall median LOS was 46 days [interquartile range (IQR): 35–60], and the median corrected gestational age at discharge was 36 weeks (IQR: 35–38). LOS and corrected gestational age at discharge increased with decreasing gestational age. The median corrected gestational age at discharge for infants at 24 weeks, 25 weeks, 26 weeks, 27–28 weeks, and 29–31 weeks were 41 weeks, 39 weeks, 38 weeks, 37 weeks and 36 weeks, respectively. Significant site variation of LOS was identified with observed median LOS from 33 to 71 days in different hospitals.ConclusionsThe study provided concurrent estimates of LOS for VPIs which survived in Chinese NICUs that could be used as references for medical staff and parents. Large variation of LOS independent of infant characteristics existed, indicating variation of care practices requiring further investigation and quality improvement.
Prediction modelling in the early detection of neonatal sepsis
Authors: Sahu Puspita , Raj Stanly Elstin Anbu , Simon Lewis Leslie Edward , Prabhu Krishnananda , Rao Mahadev , Kunhikatta Vijayanarayana 
Published: January 2022

Abstract
Background
Prediction modelling can greatly assist the health-care professionals in the management of diseases, thus sparking interest in neonatal sepsis diagnosis. The main objective of the study was to provide a complete picture of performance of prediction models for early detection of neonatal sepsis.

Methods
PubMed, Scopus, CINAHL databases were searched and articles which used various prediction modelling measures for the early detection of neonatal sepsis were comprehended. Data extraction was carried out based on Critical Appraisal and Data Extraction for Systematic Reviews of Prediction Modelling Studies checklist. Extricate data consisted of objective, study design, patient characteristics, type of statistical model, predictors, outcome, sample size and location. Prediction model Risk of Bias Assessment Tool was applied to gauge the risk of bias of the articles.

Results
An aggregate of ten studies were included in the review among which eight studies had applied logistic regression to build a prediction model, while the remaining two had applied artificial intelligence. Potential predictors like neonatal fever, birth weight, foetal morbidity and gender, cervicovaginitis and maternal age were identified for the early detection of neonatal sepsis. Moreover, birth weight, endotracheal intubation, thyroid hypofunction and umbilical venous catheter were promising factors for predicting late-onset sepsis; while gestational age, intrapartum temperature and antibiotics treatment were utilised as budding prognosticators for early-onset sepsis detection.

Conclusion
Prediction modelling approaches were able to recognise promising maternal, neonatal and laboratory predictors in the rapid detection of early and late neonatal sepsis and thus, can be considered as a novel way for clinician decision-making towards the disease diagnosis if not used alone, in the years to come.
Appraisal of water quality and ecological sensitivity with reference to riverfront development along the River Gomti, India
Authors: Khan Ramsha , Saxena Abhishek , Shukla Saurabh , Goel Pooja , Bhattacharya Prosun , Li Peiyue , Ali Esmat F. , Shaheen Sabry M. 
Published: January 2022

AbstractThe conflict between the vitality of natural ecosystem versus artificially developed systems has existed since decades. The ecological sensitivity and socio-economic aspects associated with riverfront development along rivers have attracted the attention of environmentalists and ecologists across the globe. The present study evaluates the impacts of channelization and riverfront development on the water quality of river Gomti through Water Pollution Index (WPI) and other statistical tools. Of the total studied sites, 75% were found to be in the ‘highly polluted’ category even after the development of riverfront. An approximate increase of 274.5% and 171.76% was witnessed in the WPI values at the midstream sites of Kudiaghat and Daliganj, respectively. This increase in the WPI values clearly stated the deteriorated water quality of river Gomti after the channelization. The major issue of domestic sewage discharge with partial or no treatment into the river seems to be unresolved even after a considerable period of riverfront development. This study can provide a reference database toward development of such projects across the globe.
Hadamard’s variational formula in terms of stress and strain tensors
Authors: Gustafsson Björn , Sebbar Ahmed 
Published: January 2022

AbstractStarting from a Lagrangian action functional for two scalar fields we construct, by variational methods, the Laplacian Green function for a bounded domain and an appropriate stress tensor. By a further variation, imposed by a given vector field, we arrive at an interior version of the Hadamard variational formula, previously considered by P. Garabedian. It gives the variation of the Green function in terms of a pairing between the stress tensor and a strain tensor in the interior of the domain, this contrasting the classical Hadamard formula which is expressed as a pure boundary variation.
Circulating miRNA as potential biomarkers for diabetes mellitus type 2: should we focus on searching for sex differences?
Authors: Kraczkowska Weronika , Stachowiak Lucyna , Pławski Andrzej , Jagodziński Paweł Piotr 
Published: January 2022

Abstract
microRNAs are non-coding molecules, approximately 22 nucleotides in length, that regulate various cellular processes. A growing body of evidence has suggested that their dysregulated expression is involved in the pathogenesis of diverse diseases, including diabetes mellitus type 2 (DM2). Early onset of this chronic and complex metabolic disorder is frequently undiagnosed, leading to the development of severe diabetic complications. Notably, DM2 prevalence is rising globally and an increasing number of articles demonstrate that DM2 susceptibility, development, and progression differ between males and females. Therefore, this paper discusses the role of microRNAs as a source of novel diagnostic biomarkers for DM2 and aims to underline the importance of sex disparity in biomarkers research. Taking into account an urgent need for the development of sex-specific diagnostic strategies in DM2, recent results have shown that circulating miRNAs are promising candidates for sex-biased biomarkers.
Evidence on Problematic Online Gaming and Social Anxiety over the Past Ten Years: a Systematic Literature Review
Authors: Gioia Francesca , Colella Gianluca Mariano , Boursier Valentina 
Published: January 2022

AbstractPurpose of ReviewThe present study aimed to review the literature concerning the relationship between problematic online gaming (POG) and social anxiety, taking into account the variables implicated in this relationship. This review included studies published between 2010 and 2020 that were indexed in major databases with the following keywords: Internet gaming, disorder, addiction, problematic, social phobia, and social anxiety.Recent FindingsIn recent years, scientific interest in POG has grown dramatically. Within this prolific research field, difficulties associated with social anxiety have been increasingly explored in relation to POG. Indeed, evidence showed that individuals who experience social anxiety are more exposed to the risk of developing an excessive or addictive gaming behavior.SummaryA total of 30 studies satisfied the initial inclusion criteria and were included in the present literature review. Several reviewed studies found a strong association between social anxiety and online gaming disorder. Furthermore, the relationships among social anxiety, POG, age, and psychosocial and comorbid factors were largely explored. Overall, the present review showed that socially anxious individuals might perceive online video games as safer social environments than face-to-face interactions, predisposing individuals to the POG. However, in a mutually reinforcing relationship, individuals with higher POG seem to show higher social anxiety. Therefore, despite online gaming might represent an activity able to alleviate psychopathological symptoms and/or negative emotional states, people might use online gaming to counterbalance distress or negative situations in everyday life, carrying out a maladaptive coping strategy.
SARS-CoV-2 detection in primary thyroid sarcoma: coincidence or interaction?
Authors: Tanda M. L. , Ippolito S. , Gallo D. , Baj A. , Novazzi F. , Genoni A. , Annoni M. , Mancini N. , Clementi N. , Finzi G. , Piantanida E. , Premoli P. , Lai A. , Dalla Gasperina D. , Maggi F. , Uccella S. 
Published: January 2022

Abstract
Introduction
Thyroid dysfunctions associated with SARS-CoV-2 are emerging in scientific literature. During the second COVID-19 epidemic spread, we evaluated a patient with the suspect of subacute thyroiditis.

Methods and results
Specimen from fine-needle aspiration of a hypoechoic undefined area was analyzed for cytology and for SARS-CoV-2 detection. SARS-CoV-2 was retrieved by real-time polymerase chain reaction on the cytologic sample, which was then cultured on Vero E6 cells and demonstrated to be cytopathic. Whole-genome sequence was deposited. Histological exam diagnosed a rare case of primary thyroid sarcoma with diffuse and strong expression of mouse double minute 2 homolog (MDM2) oncoprotein. Ultrastructural examination confirmed, in several neoplastic cells, the presence of viral particles in cytoplasmic vacuoles.

Conclusions
In our hypothesis, SARS-CoV-2 and sarcoma coexistence could represent a synergistic interplay, ultimately favoring both viral persistence and tumor proliferation: the overexpression of MDM2 in tumor cells might have generated a favorable immunological niche for SARS-CoV-2 localization and, in turn, SARS-CoV-2 could have favored tumor growth by inducing MDM2-mediated p53 downregulation. Functional studies are needed to confirm this suggestive pathway.
Compilation and evaluation of the Spanish SatiCorpus 2021 for satire identification using linguistic features and transformers
Authors: García-Díaz José Antonio , Valencia-García Rafael 
Published: January 2022

AbstractSatirical content on social media is hard to distinguish from real news, misinformation, hoaxes or propaganda when there are no clues as to which medium these news were originally written in. It is important, therefore, to provide Information Retrieval systems with mechanisms to identify which results are legitimate and which ones are misleading. Our contribution for satire identification is twofold. On the one hand, we release the Spanish SatiCorpus 2021, a balanced dataset that contains satirical and non-satirical documents. On the other hand, we conduct an extensive evaluation of this dataset with linguistic features and embedding-based features. All feature sets are evaluated separately and combined using different strategies. Our best result is achieved with a combination of the linguistic features and BERT with an accuracy of 97.405%. Besides, we compare our proposal with existing datasets in Spanish regarding satire and irony.
Cultural Images of Labor Conflict and Coordination: Literature and the Evolution of Industrial Relations Systems
Authors: Martin Cathie Jo , Nijhuis Dennie Oude , Olsson Erik 
Published: January 2022

AbstractDenmark, Sweden and the Netherlands have different historical patterns of industrialization, but developed similar patterns of industrial coordination and cooperation. Theories accounting for industrial relations systems (economic structure, power resources, and party/electoral systems) have difficulty accounting for the similarities among these cases. Therefore, we explore the historical depictions of labor appearing in literature to evaluate whether cross-national distinctions in cultural conceptions of labor have some correspondence to distinctions between coordinated and liberal industrial relations systems. We hypothesize that historical literary depictions of labor are associated with the evolution of industrial systems, and apply computational text analyses to large corpora of literary texts. We find that countries (Denmark, Sweden and the Netherlands) with coordinated, corporatist industrial relations in the 20th century share similar cultural constructions about labor relations dating back to at least 1770. Literary depictions found in modern coordinated/corporatist countries are significantly different from those found in Britain, a country with liberal/pluralist industrial relations systems. The research has significance for our understanding of the role of culture in the evolution of modern political economies.
Decreasing Dust Over the Middle East Partly Caused by Irrigation Expansion
Authors: Xia Wenwen , Wang Yong , Wang Bin 
Published: January 2022

AbstractThe importance of the effects of anthropogenic activities on modulating the global dust cycle has been increasingly recognized. Over the Middle East, we find in observations that there has been a significant decrease in dust optical depth from 2007 to 2019 during which global irrigated areas especially in the Middle East and South Asia have rapidly expanded. Whether irrigation expansion contributes to the decrease of dust in the Middle East is investigated based on observations/reanalyses and global climate model simulations with and without irrigation. Results show that irrigation over the northeast Middle East and Pakistan supplements water to the soil. By increasing local evaporation and moisture advection, irrigation enhances precipitation over the whole Middle East and the northwest Indian subcontinent. As a result, dust wet deposition by precipitation is elevated. Owing to irrigation‐induced land surface cooling, surface wind speed decreases as the planetary boundary layer becomes stable. Along with increased soil moisture, reduced surface wind speed suppresses local dust emissions. Enhanced dust wet deposition and suppressed dust emissions cause atmospheric dust reduction over the Middle East. Vegetation greening in the Middle East as the climate warms has no contribution because there is no obvious trend found in observations.
Supernova Rates and Burial of Organic Matter
Authors: Svensmark Henrik 
Published: January 2022

AbstractLife on Earth appears to have evolved under the influence of supernovae activity in the solar neighborhood. Supernovae frequency regulates the flux of cosmic ray particles arriving at the top of the Earth's atmosphere, where empirical evidence supports a close connection between cosmic rays, clouds, and climate. Burial of organic matter in marine sediments follows cosmic rays variations for more than 3.5 Gyr and in detail during the last 500 Myr. The supernovae link to the burial of organic matter may be due to climate‐induced changes in the atmospheric and oceanic circulation affecting the availability of nutrients and the bioproductivity in the oceans. A higher bioproductivity then leads to a more extensive burial of organic matter. Support for this scenario comes from a proxy of nutrient concentrations in the ocean which covaries with the supernovae frequency. The results suggest a fundamental connection between supernovae rates and life on Earth.
An Adaptive Hybrid Vertical Equilibrium/Full‐Dimensional Model for Compositional Multiphase Flow
Authors: Becker Beatrix , Guo Bo , Buntic Ivan , Flemisch Bernd , Helmig Rainer 
Published: January 2022

AbstractEfficient compositional models are required to simulate underground gas storage in porous formations where, for example, gas quality (such as purity) and loss of gas due to dissolution are of interest. We first extend the concept of vertical equilibrium (VE) to compositional flow, and derive a compositional VE model by vertical integration. Second, we present a hybrid model that couples the efficient compositional VE model to a compositional full‐dimensional model. Subdomains, where the compositional VE model is valid, are identified during simulation based on a VE criterion that compares the vertical profiles of relative permeability at equilibrium to the ones simulated by the full‐dimensional model. We demonstrate the applicability of the hybrid model by simulating hydrogen storage in a radially symmetric, heterogeneous porous aquifer. The hybrid model shows excellent adaptivity over space and time for different permeability values in the heterogeneous region, and compares well to the full‐dimensional model while being computationally efficient, resulting in a runtime of roughly one‐third of the full‐dimensional model. Based on the results, we assume that for larger simulation scales, the efficiency of this new model will increase even more.
Efficacy of front-line immunochemotherapy for follicular lymphoma: a network meta-analysis of randomized controlled trials
Authors: Wang Yucai , Zhou Shouhao , Qi Xinyue , Yang Fang , Maurer Matthew J. , Habermann Thomas M. , Witzig Thomas E. , Wang Michael L. , Nowakowski Grzegorz S. 
Published: January 2022

Abstract
Front-line treatment for follicular lymphoma has evolved with the introduction of maintenance therapy, bendamustine (Benda), obinutuzumab (G), and lenalidomide (Len). We conducted a random-effects Bayesian network meta-analysis (NMA) of phase 3 randomized controlled trials (RCTs) to identify the regimens with superior efficacy. Progression-free survival (PFS) was compared between 11 modern regimens with different immunochemotherapy and maintenance strategies. G-Benda-G resulted in with the best PFS, with an HR of 0.41 compared to R-Benda, a surface under the cumulative ranking curve (SUCRA) of 0.97, a probability of being the best treatment (PbBT) of 72%, and a posterior ranking distribution (PoRa) of 1 (95% BCI 1–3). This was followed by R-Benda-R4 (HR = 0.49, PbBT = 25%, PoRa = 2) and R-Benda-R (HR = 0.60, PbBT = 3%, PoRa = 3). R-CHOP-R (HR = 0.96) and R-Len-R (HR = 0.97) had similar efficacy to R-Benda. Bendamustine was a better chemotherapy backbone than CHOP either with maintenance (R-Benda-R vs R-CHOP-R, HR = 0.62; G-Benda-G vs G-CHOP-G, HR = 0.55) or without maintenance therapy (R-Benda vs R-CHOP, HR = 0.68). Rituximab maintenance improved PFS following R-CHOP (R-CHOP-R vs R-CHOP, HR = 0.65) or R-Benda (R-Benda-R vs R-Benda, HR = 0.60; R-Benda-R4 vs R-Benda, HR = 0.49). In the absence of multi-arm RCTs that include all common regimens, this NMA provides an important and useful guide to inform treatment decisions.