bluuebunny/crossref_metadata_2025_split huggingface dataset:
A multicenter phase II study of bendamustine, rituximab, and cytarabine (BRAC) for relapsed or refractory patients with follicular lymphoma or mantle cell lymphoma
Authors: Nakamura Nobuhiko , Kasahara Senji , Kitagawa Junichi , Nakamura Hiroshi , Sawada Michio , Fukuno Kenji , Shibata Yuhei , Kaneda Yuto , Hara Takeshi , Kanemura Nobuhiro , Tsurumi Hisashi , Shimizu Masahito 
Published: February 2022

AbstractThis phase II clinical trial aimed to evaluate the efficacy and safety of the combination therapy of bendamustine, cytarabine, and rituximab (BRAC) in patients with relapsed or refractory follicular lymphoma (FL) or mantle cell lymphoma (MCL). Thirteen patients were enrolled and received a median of 4 cycles (range 2–6) of BRAC. The complete response rate was 61.5%, and the overall response rate was 84.6%; the 2-year overall survival was 76.9%, and the 2-year progression-free survival was 69.2%. Although all patients received G-CSF prophylaxis, grade 3 or higher neutropenia was observed in all cycles, and the incidence of febrile neutropenia was 20%. Grade 4 thrombocytopenia was observed in 92.5% of all cycles, and platelet transfusion was performed in 94%. Although hematological toxicity was relatively high, BRAC therapy was effective for relapsed and refractory FL or MCL. Further studies are needed to determine the optimal dose of BRAC therapy.Trial registration The UMIN Clinical Trials Registry, UMIN000009797. Registered 17 January 2013, https://upload.umin.ac.jp/cgi-open-bin/ctr/ctr_view.cgi?recptno=R000011103
Tensor extrapolation: an adaptation to data sets with missing entries
Authors: Schosser Josef 
Published: February 2022

Abstract
Background
Contemporary data sets are frequently relational in nature. In retail, for example, data sets are more granular than traditional data, often indexing individual products, outlets, or even users, rather than aggregating them at the group level. Tensor extrapolation is used to forecast relational time series data; it combines tensor decompositions and time series extrapolation. However, previous approaches to tensor extrapolation are restricted to complete data sets. This paper adapts tensor extrapolation to situations with missing entries and examines the method’s performance in terms of forecast accuracy.

Findings
To base the evaluation on time series with both diverse and controllable characteristics, the paper develops a synthetic data set closely related to the context of retailing. Calculations performed on these data demonstrate that tensor extrapolation outperforms the univariate baseline. Furthermore, a preparatory completion of the data set is not necessary. The higher the fraction of missing data, the greater the superiority of tensor extrapolation in terms of prediction error.

Conclusions
Forecasting plays a key role in the optimization of business processes and enables data-driven decision making. As such, tensor extrapolation should be part of the forecaster’s toolkit: Even if large parts of the data are missing, the proposed method is able to extract meaningful, latent structure, and to use this information in prediction.
Predicting clinical outcomes of radiotherapy for head and neck squamous cell carcinoma patients using machine learning algorithms
Authors: Gangil Tarun , Shahabuddin Amina Beevi , Dinesh Rao B. , Palanisamy Krishnamoorthy , Chakrabarti Biswaroop , Sharan Krishna 
Published: February 2022

Abstract
Background
Radiotherapy is frequently used to treat head and neck Squamous cell carcinomas (HNSCC). Treatment outcomes being highly uncertain, there is a significant need for robust predictive tools to improvise treatment decision-making and better understand HNSCC by recognizing hidden patterns in data. We conducted this study to identify if Machine Learning (ML) could accurately predict outcomes and identify new prognostic variables in HNSCC.

Method
Retrospective data of 311 HNSCC patients treated with radiotherapy between 2013 and 2018 at our center and having a follow-up of at least three months' duration were collected. Binary-classification prediction models were developed for: Choice of Initial Treatment, Residual disease, Locoregional Recurrence, Distant Recurrence, and Development of New Primary. Clinical data were pre-processed using Imputation, Feature selection, Minority Oversampling, and Feature scaling algorithms. A method to retain original characteristics of dataset in testing samples while performing minority oversampling is illustrated. The classification comparison was performed using Random Forest (RF), Kernel Support Vector Machine (KSVM), and XGBoost classification algorithms for each model.

Results
For the choice of the initial treatment model, the testing accuracy was 84.58% using RF. The distant recurrence, locoregional recurrence, new-primary, and residual models had a testing accuracy (using KSVM) of 95.12%, 77.55%, 98.61%, and 92.25%, respectively. The important clinical determinants were identified using Shapely Values for each classification model, and the mean area under the curve (AUC) for the receiver operating curve was plotted.

Conclusion
ML was able to predict several clinically relevant outcomes, and with additional clinical validation, could facilitate recognition of novel prognostic factors in HNSCC.
Randomised controlled trials of mood stabilisers for people with autism spectrum disorder: systematic review and meta-analysis
Authors: Limbu Bharati , Deb Shoumitro , Roy Meera , Lee Rachel , Roy Ashok , Taiwo Oluwafemi 
Published: February 2022

BackgroundDespite the widespread use of psychotropic medications in people with autism spectrum disorder (ASD), there is limited evidence to suggest that psychotropic medications including mood stabilisers are effective in individuals with ASD.AimsTo carry out a systematic review and meta-analysis of randomised controlled trials (RCTs) that assessed the effectiveness of mood stabilisers in people with ASD.MethodWe searched the following databases: Cochrane Library, MEDLINE, Embase, CINAHL, PsycINFO, ERIC, DARE, and ClinicalTrials.gov. In addition, we hand-searched 12 relevant journals. We used the Cochrane Risk of Bias and Jadad scores to assess the quality of included RCTs. We carried out a meta-analysis using a random-effects model.ResultsWe included eight RCTs (four on valproate, two on levetiracetam, and one each on lamotrigine and topiramate) that included a total of 310 people with ASD, primarily children. Outcomes were based on core and associated ASD symptoms including irritability and aggression but not bipolar disorder. Only two small studies (25%) from the same group showed definite superiority over placebo and one over psychoeducation alone. Meta-analysis of pooled data on the Aberrant Behaviour Checklist-irritability, Clinical Global Impression Scale-improvement, and Overt Aggression Scale (OAS)/OAS-modified did not show any significant inter-group difference. The rates of adverse effects did not show any significant inter-group difference.ConclusionsGiven the methodological flaws in the included studies and the contradictory findings, it is difficult to draw any definitive conclusion about the effectiveness of mood stabilisers to treat either ASD core symptoms or associated behaviours. Robust large-scale RCTs are needed in the future to address this issue.PROSPERO registration: CRD42021255467 on 18 May 2021.
Model Girls and Model Dolls in Nineteenth-Century France
Authors: Curtis Sarah A. 
Published: February 2022

AbstractThis article examines the boom in dolls, doll literature (storybooks and magazines), and doll play in nineteenth-century France, when dolls became important commodities as well as pedagogical tools for training girls in their future roles as mothers. However, the conservative messages about girls' behavior encoded in most of the doll literature were undermined, at least in part, by contrasting messages about consumerism, as well as the daring of dolls themselves as heroines of this literature. Doll storybooks opened up entire imaginative worlds that allowed girls to live vicariously through the escapades of their dolls and act out the scenes represented in the books. Doll magazines straddled the line between moralizing and selling, providing advice for both how to behave and where to shop. Evidence from memoirs suggests that girls both followed and departed from the scripts written for them by the dolls themselves and the literature around them.Cet article examine les poupées, les livres et les journaux des poupées en France au XIXe siècle, lorsque les poupées sont devenues des commodités importantes ainsi que des outils pédagogiques pour éduquer les jeunes filles dans leur futur rôle maternel. Pourtant, les messages conservateurs sur le comportement des filles codés dans la plupart des histoires de poupées étaient subvertis, au moins en partie, par d'autres messages sur l'importance de la consommation et par les aventures des poupées elles-mêmes, en tant qu'héroïnes de ces textes. Les histoires des poupées ouvraient des mondes imaginatifs qui permettaient aux filles de vivre par procuration les aventures de leurs poupées et de jouer les scènes représentées dans ces histoires. Les journaux des poupées occupaient une position ambiguë entre la promotion de la morale et celle du commerce. L’évidence des mémoires suggère que les filles aient suivi et aussi dévié des scénarios écrits par les poupées elles-mêmes et les textes autour d'elles.
Femmes, querelles galantes du dix-septième siècle et histoire littéraire
Authors: Dufour-Maître Myriam 
Published: February 2022

Abstract
L’article propose une réflexion sur la construction des querelles galantes, en leur temps puis dans l’histoire littéraire, du point de vue de la place qu’y occupent les femmes et les autrices. Dans la plupart des cas, leur accès à l’autorité ne passe pas par la querelle, ce qui les rend invisibles dans une historiographie littéraire étroitement focalisée sur l’affrontement des corps constitués (XVIIIe siècle), ou animée par le paradigme épique (XIXe siècle et début du XXe siècle). La valorisation exclusive du rôle de protagoniste empêche de mesurer l’efficacité de postures féminines plus discrètes d’instigation, d’observation, d’arbitrage, d’esquive, de surélévation « au-dessus de la mêlée », voire d’ironie dissolvante. La vitalité sur trois siècles des violents repoussoirs que sont la harangère, la pédante et la précieuse éclaire ces stratégies « obliques », et permet d’apprécier le prix très élevé qu’ont dû payer celles qui osèrent entrer dans la lice.
The CAFO in the Bioreactor
Authors: Guthman Julie 
Published: February 2022

AbstractA 2020 report published by the think tank RethinkX predicts the “second domestication of plants and animals, the disruption of the cow, and the collapse of industrial livestock farming” by 2035. Although typical of promissory discourses about the future of food, the report gives unusual emphasis to the gains of efficiency and near limitless growth that will come by eradicating confined livestock and aquaculture operations and replacing them with protein engineered at a molecular level and fermented in bioreactors. While there are many reasons to disrupt industrialized livestock production, lack of efficiency is not one of them. This article examines to what extent this so-called second domestication departs from the radical transformations of animal biologies and living conditions to which it responds. Drawing on canonical texts in agrarian political economy, it parses animal bio-industrialization into sets of practices that accelerate productivity, standardize animal life and infrastructures, and reduce risk to maximize efficiency. It shows these practices at work through recent ethnographic accounts of salmon aquaculture and pork production to illustrate how efforts to override temporalities and contain species in unfamiliar habitats, in the name of efficiency, may be the source of vulnerability in such production systems rather than their strength.
Microwave-assisted Green Synthesis of Mesoporous Zeolite Adsorbents for Direct Air Capture of CO2
Authors: Nagase Takako , Miyakawa Masato , Nishioka Masateru , Ikeda Takuji 
Published: February 2022

Abstract
Mesoporous LTA-zeolites with a Si/Al molar ratios of 1.1–1.8 were synthesized using a template-free flow microwave heating system. Because the obtained mesoporous zeolites showed relatively lower hydrophilicity at RH &lt; 50% and high CO2/N2 separation performance, it could be expected to provide a direct air capture of carbon dioxide for onsite usage in consumer sections.
On the development of B-Raf inhibitors acting through innovative mechanisms
Authors: Pinzi Luca 
Published: February 2022

B-Raf is a protein kinase participating to the regulation of many biological processes in cells. Recent studies have demonstrated that this protein is frequently overactivated in human cancers, especially when it bears activating mutations. In recent years, few ATP-competitive inhibitors of B-Raf have been marketed for the treatment of melanoma and are currently under clinical evaluation on a variety of other types of cancer. Although the introduction of drugs targeting B-Raf has provided significant advances in cancer treatment, responses to such ATP-competitive inhibitors remain limited, mainly due to selectivity issues, side effects, narrow therapeutic windows, and the insurgence of drug resistance. Impressive research efforts have been made so far towards the identification of novel ATP-competitive modulators with improved efficacy against cancers driven by mutant Raf monomers and dimers, some of them showing good premises. However, several limitations could still be envisioned for these compounds, according to recent literature data. Besides, increased attentions have recently arisen around approaches based on the design of allosteric modulators, polypharmacology, PROTACs and drug repurposing for the targeting of B-Raf proteins. The design of compounds acting through such innovative mechanisms is rather challenging. However, novel valuable therapeutic opportunities can be envisioned on these drugs, as they act through innovative mechanisms in which limitations typically observed for approved ATP-competitive B-Raf inhibitors are less prone to emerge. In this article, the most recent approaches adopted for the design of non-ATP competitive inhibitors targeting B-Raf are described, discussing also on the possibilities, ligands acting through such innovative mechanisms could provide for the obtainment of more effective therapies.
“My life is not going to be the same, my health is going to improve”: a cross-sectional qualitative study of patients’ experiences of living with chronic respiratory symptoms and their views on a proposed pulmonary rehabilitation program at Queen Elizabeth Central Hospital, Blantyre, Malawi
Authors: BICKTON FANUEL MECKSON , Mankhokwe Talumba , Mitengo Martha , Limbani Felix , Shannon Harriet , Rylance Jamie , Chisati Enock 
Published: February 2022

Background: Malawi’s population has a substantial burden of chronic respiratory symptoms. Elsewhere, patients with these symptoms have benefited from pulmonary rehabilitation (PR), a program of exercise training, education, and behaviour management. Practically, PR in Malawi may not be delivered in the same format as elsewhere due to substantial contextual differences. These differences necessitate adaptation of the intervention to Malawi’s setting to be acceptable and effective. This study explored patients’ experiences of living with chronic respiratory symptoms and their views on a proposed PR program at Queen Elizabeth Central Hospital, Blantyre, Malawi, to inform the design of an individualized and culturally adapted PR program. Methods: This was a cross-sectional qualitative study. Face-to-face, one-to-one semi-structured in-depth interviews were undertaken to data saturation. Interviews were audio-recorded, transcribed verbatim, and Chichewa transcripts were translated into English. The transcripts were anonymized and thematically analysed using an inductive approach. Results: We recruited 10 patients (five males and five females) with functionally limiting chronic respiratory symptoms, with documented causes including chronic obstructive pulmonary disease, asthma, post-tuberculosis lung disease, and bronchiectasis. Symptoms most frequently included dyspnoea, with associated functional limitations including the reduced performance of activities of daily living. Participants’ coping strategies most frequently included the use of inhalers. Participants were motivated to undertake the PR program owing to its anticipated benefits including improved health. They perceived transport costs and competing commitments as barriers to participation. The participant group gender mix and public nature of the program were considered socio-culturally sensitive by some participants. Conclusions: The functionally limiting dyspnoea most frequently experienced by the study participants would be amenable to a PR program. To ensure participation by eligible patients, pre-program assessments should consider patient access to transport, suitability of the timing for the program’s sessions, and patient views on organizational aspects of the program considered social-culturally sensitive.
The Capital Market Consequences of Tenure-Based Voting Rights: Evidence from the Florange Act
Authors: Bourveau Thomas , Brochet François , Garel Alexandre 
Published: February 2022

We examine the consequences of a regulatory intervention aimed at generalizing tenure voting in French public companies. The 2014 Florange Act departs from the ‘one share one vote’ principle by automatically granting double-voting rights (DVR) to shares held for at least two years. However, firms can opt out through an annual meeting vote. We document three main findings. First, firms that adopt DVR by default experience a decrease in long-term foreign institutional ownership offset by an increase in insider/family ownership. Second, those firms significantly underperform in terms of stock returns after Florange relative to those that reject DVR. Third, their environmental and social performance deteriorates. Collectively, our evidence casts doubt on the merit of regulation-induced tenure voting as a desirable corporate governance mechanism. This paper was accepted by Brian Bushee, accounting. Funding: This work was supported by Research Grants Council of Hong Kong [16513216]. We also acknowledge the General Research Fund of the Research Grants Council of Hong Kong [Project No. 16505017] for financial support. Supplemental Material: The e-companion and data are available at https://doi.org/10.1287/mnsc.2022.4320 .
Partner’s violence during the COVID-19 lockdown and women’s fear: a study involving anti-violence centres in Italy
Authors: Romito Patrizia , Marchand-Martin Laetitia , Pellegrini Martina , Saurel-Cubizolles Marie-Josèphe 
Published: February 2022

This study explores how women’s fear is related to violence by a partner during the COVID-19 lockdown in Italy. Data come from a sample of 238 women, attending five anti-violence centres in June–September 2020, 44 per cent were cohabiting and 56 per cent not cohabiting with the perpetrator. A questionnaire administered by the advocates allowed us to collect information about several types of violence and their evolution during the lockdown, the feeling of fear, the impossibility of going out alone and help-seeking strategies.
Most of these women lived with the fear of their aggressor, more often if they cohabited with him, 76 per cent instead of 57 per cent if not. Despite this high prevalence, the main determinants of not going out alone or help-seeking were the intensity of violence and its increase during the lockdown more than the women’s fear, even if the cohabitation status is considered.
Fear strongly impairs the quality of daily life. In the context of this pandemic, it was an addition to the various damages exerted by the violence, coupled for some women with difficult social conditions. Professionals working with these women should consider fear but keep in mind that the factor to suppress is the violence.
sFlt-1/PlGF ratio for prediction of preeclampsia in clinical routine: A pragmatic real-world analysis of healthcare resource utilisation
Authors: Dathan-Stumpf Anne , Rieger Anna , Verlohren Stefan , Wolf Cyrill , Stepan Holger 
Published: February 2022

Background
We investigated the impact of the soluble fms-like tyrosine kinase 1 (sFlt-1)/placental growth factor (PlGF) ratio to predict short-term risk of preeclampsia on clinical utility and healthcare resource utilisation using real-world data (RWD), and compared findings with health economic modelling from previous studies.

Methods and findings
This retrospective analysis compared data from the German population of a multicentre clinical study (PROGNOSIS, n = 203; sFlt-1/PlGF ratio blinded and unavailable for decision-making) with RWD from University Hospital Leipzig, Germany (n = 281; sFlt-1/PlGF ratio used to guide clinical decision-making). A subgroup of the RWD cohort with the same inclusion criteria as the PROGNOSIS trial (RWD prediction only, n = 99) was also included. sFlt-1/PlGF ratio was measured using fully automated Elecsys® sFlt-1 and PlGF immunoassays (cobas e analyser; Roche Diagnostics).
A similar proportion of women in the RWD and PROGNOSIS cohorts experienced preeclampsia (14.95% vs. 13.79%; p = 0.7938); a smaller proportion of women in the RWD prediction only cohort experienced preeclampsia versus PROGNOSIS (6.06%; p = 0.0526). In women with preeclampsia, median gestational age at delivery (weeks) was comparable in the RWD and PROGNOSIS cohorts (34.0 vs. 34.3, p = 0.5895), but significantly reduced in the RWD prediction only cohort versus PROGNOSIS (27.1, p = 0.0038). sFlt-1/PlGF ratio at baseline visit was not statistically significantly different for the RWD and PROGNOSIS cohorts, irrespective of preeclampsia outcome. Hospitalisations for confirmed preeclampsia were significantly shorter in the RWD cohort versus PROGNOSIS (median 1 vs. 4 days, p = 0.0093); there was no significant difference between RWD prediction only and PROGNOSIS (3 days, p = 0.9638). All-cause hospitalisations were significantly shorter in the RWD (median 1 day; p<0.0001) and RWD prediction only (1 day; p<0.0001) cohorts versus PROGNOSIS (3 days).

Conclusions
This study supports the findings of previous studies, showing that routine clinical use of the sFlt-1/PlGF ratio may result in shorter duration of hospitalisations, with potential economic benefits.
Note on structural properties of graphs
Authors: Arreola-Bautista Luis D. , Reyna Gerardo , Romero-Valencia Jesús , Sigarreta José M. 
Published: February 2022

Abstract
In this paper, we establish sufficient and necessary conditions for the existence of abelian subgroups of maximal order of a finite group

G

G

, by means of its commuting graph. The order of these subgroups attains the bound

c
=
∣

[

x

1

]

∣

+
⋯
+

∣

[

x

m

]

∣

c=| \left[{x}_{1}]| \hspace{-0.25em}+\cdots +\hspace{-0.25em}\hspace{0.33em}| \left[{x}_{m}]|

, where

[

x

i

]

\left[{x}_{i}]

denotes the conjugacy class of

x

i

{x}_{i}

in

G

G

and

m

m

is the smallest integer

j

j

such that

∣

[

x

1

]

∣

+
⋯
+
∣

[

x

j

]

∣
≥
∣

C

G

(

x

j

)

∣

| \left[{x}_{1}]| \hspace{-0.25em}+\cdots +| \left[{x}_{j}]| \ge | {C}_{G}\left({x}_{j})|

, where

C

G

(

x

j

)

{C}_{G}\left({x}_{j})

is the centralizer of

x

j

{x}_{j}

in

G

G

.
Crystal structure of catena-poly[{μ2-3-carboxy-2,3-bis((4-methylbenzoyl)oxy)propanoato-κ2
O:O′}tris(methanol-κ1
O)lanthanum(III)], C63H63LaO27
Authors: Han Yingying , Feng Sisi , Lu Liping 
Published: February 2022

Abstract
C63H63LaO27, trigonal, R3 (no. 146), a = 27.5427(11) Å, c = 7.7330(4) Å, V = 5080.3(5) Å3, Z = 3, R

gt
(F) = 0.037, wR

ref
(F
2) = 0.096, T = 100 K.