bluuebunny/crossref_metadata_2025_split huggingface dataset:
Quality of Care in the Last Year of Life: Adaptation and Validation of the German “Views of Informal Carers’ Evaluation of Services – Last Year of Life – Cologne”
Authors: Dust Gloria , Schippel Nicolas , Stock Stephanie , Strupp Julia , Voltz Raymond , Rietz Christian 
Published: March 2022

Abstract
Background: To inform quality improvement and strengthen services provided in the last year of life, measuring quality of care is essential. For Germany, data on care experiences in the last year of life that go beyond diagnoses and care settings are still rare. Aim of this study was to develop and validate a German version of the ‘Views of Informal Carers’ Evaluation of Services – Short Form (VOICES-SF)’ suitable to assess the quality of care and services received across settings and healthcare providers in the German setting in the last year of life (VOICES-LYOL-Cologne). Methods: VOICES-SF was adapted and translated following the ‘TRAPD’ team approach. Data collected in a retrospective cross-sectional survey with bereaved relatives in the region of Cologne, Germany were used to assess validity and reliability.Results: Data from 351 bereaved relatives of adult decedents were analysed. The VOICES-LYOL-Cologne demonstrated construct validity in performing according to expected patterns, i.e. correlation of scores to care experiences and significant variability based on care settings. It further correlated with the PACIC-S9 Proxy, indicating good criterion validity. The newly added scale “subjective experiences of process and outcome of care in the last year of life” showed good internal consistency for each given care setting, except for the homecare setting. Test-retest analyses revealed no significant differences in satisfaction ratings according to the length of time since the patient’s death. Overall, our data demonstrated the feasibility of collecting patient care experiences reported by proxy-respondents across multiple care settings.Conclusions: VOICES-LYOL-Cologne is the first German instrument to analyse care experiences in the last year of life in a comprehensive manner and encourages further research in German-speaking countries. This instrument enables the comparison of quality of care between settings and may be used to inform local and national quality improvement activities.Trial registration: This study was registered in the German Clinical Trials Register (DRKS00011925; Date of registration: 13/06/2017).
Comparison of Live Birth Rate Among PPOS, GnRH Antagonist and GnRH Agonist in POSEIDON Group 3
Authors: Gui Juan , Chen Jiao , Liu Qian , Wang Xiaochen , Xie Qingzhen 
Published: March 2022

Abstract
Background
It is difficult to select an ovarian stimulation protocol for the patients with poor ovarian reserve (POR) because few oocytes are retrieved in a single controlled ovarian stimulation (COS) cycle. The aim of this study was to compare the pregnancy outcomes of different protocols in POSEIDON Group 3 patients.
Methods
This was a retrospective cohort study. Patients met the POSEIDON Group 3 criteria who underwent assisted reproductive technology at the Reproductive center of Renmin Hospital of Wuhan University between April 2019 and August 2021 were included. The COS protocols included progestin-primed ovarian stimulation (PPOS), GnRH antagonist and GnRH agonist protocols. The live birth rate (LBR) was the primary outcome. The secondary outcome measures were number of oocytes retrieved, duration of gonadotropin (Gn) treatment, amount of Gn administered, fertilization rates, chemical and clinical pregnancy.
Results
A total of 309 women met the POSEIDON Group 3 criteria were included for analysis. When compared with PPOS group and GnRH antagonist group, anti-Mullerian hormone, antral follicle count and oocytes retrieved were significantly higher in GnRH agonist group (P = 0.021; P < 0.001; P < 0.001); the basal FSH value was significantly lower in GnRH agonist group (P = 0.006); the estradiol values on trigger day and growth hormone utilization rate were significantly increased in GnRH agonist group (P < 0.001; P = 0.001). However, there was no significant difference in the outcomes of embryos, without significant difference in 2 pronuclear rate, transplantable embryo rate and high-quality embryo rate among the three groups. There was also no significant difference in pregnancy outcomes, although the clinical pregnancy rate (61% vs.51.2% vs.44.9%) and LBR (33.3% vs.23.3% vs.23.2%) were higher in GnRH agonist group than PPOS and GnRH antagonist groups, but not statistically significant. The chemical pregnancy rate was significantly higher in GnRH agonist group than GnRH antagonist group (80.5% vs. 56.7%, P = 0.008). LH values on trigger day were significantly higher in GnRH antagonist group than the other two groups (P < 0.001). The cycle cancellation rate and miscarriage rate were highest in PPOS group, but without significant difference.
Conclusion
For patients with POR diagnosed as POSEIDON Group 3, the LBR is comparable among the PPOS, GnRH antagonist and GnRH agonist protocols. Considering the economic cost and the prevalence of COVID-19, it is recommended to use the short COS regimens with fresh embryo transplantation.
Applicability of the Mexican Ovitrap System for Aedes Vector Surveillance in Los Patios, Colombia
Authors: Wright Eduardo , Carrillo Maria Angelica , Matamoros David , Sanchez Rocío Cárdenas , Yañez Johanna , Lorenzo Giusseppe , Kroeger Axel 
Published: March 2022

Abstract
Background: Vector surveillance has been ongoing since the 1960’s through larval surveys, which are not useful to serve as an alarm indicator for outbreak prediction since they are usually done in an unsystematic way. This can be achieved with the ovitrap system. This study aimed to determine the feasibility, required resources and costs of installing and maintaining an ovitrap vector surveillance system in a municipality of Colombia.Methods: The study applied a cross sectional design including the mapping of target houses, implementation of the ovitrap system (following the Mexican ovitrap model) and an analysis of resource requirements. The mapping was done using street maps from Google Earth. 40 ovitraps were manufactured and installed on 10 blocks (1 ovitrap on each side of every cardinal point of the block, every third block), and revised weekly by two vector control technicians for a four-week period. Personal interviews with the technicians regarding costs of daily income, transport needs of human resources and requirement of equipment for manufacturing and maintaining the ovitraps, were conducted for the cost analysis. Results: A map of the 40 ovitrap geolocations facilitated the implementation. Entomological findings were expressed with six indicators. These were (results in brackets): Process indicators: Percent of acceptance by houseowners (76.9%), Percent of relocation of traps (5%), Percent of ovitraps examined in 4 study weeks (97.5%, 97.5%, 97.5%, 100%), Percent of intact ovitraps (92.5%, 97.5%, 97.5%, 100%). Result indicators: Percent of positive ovitraps (80%, 90%, 75%, 97.5%), Percent of positive blocks (100%). Operational indicators: Time for the installation of 40 ovitraps (10h15m), time for the weekly reading and reinstallation (7h40m, 7h15m, 7h53m, 7h), Time for data transmission to the operational centre (8h, 4h, 2h, 2h). Cost of installing and reviewing 40 ovitraps during four weeks: COL$1,142,304.47 or US$297. Projection of costs for covering the entire municipality of Los Patios (95000 inhabitants) with 348 ovitraps in one year: COL$24,631,329.27 or US$6,404.14. Conclusions: The implementation of the ovitrap system is feasible and affordable in Colombian municipalities and other endemic areas since most of the costs are already covered by the vector control services (salaries and transport).
Study on molecular structure model and reactivity of spent mushroom substrate: experiment and simulation
Authors: hou dongmeng , hong qin 
Published: March 2022

Abstract
The infrastructure features of the spent mushroom substrate (SMS) were detected and explored based on experimental data acquired from Fourier Transform Infrared Spectroscopy (FTIR), Pyrolysis-Gas Chromatography/Mass Spectrometry (Py-GC/MS) as well as Thermogravimetric Analysis (TG). Further, molecular simulation methods were combined with diverse testing technologies to build the 2D models and associated 3D models from cellulose, hemicellulose, and lignin. Eventually, a rational 3D model was constructed for SMS using complicated geometry optimization calculations and annealing dynamics simulations. According to the Mulliken population analysis and electron density analysis, the π–π conjugation effect of the aromatic ring structures was obviously influenced by the oxygen atoms; thus, resulting in the electron accumulation on these oxygen atoms. At the same time, in the Furan ring and pyran ring structures, oxygen exhibited a greater electronic charge density and reactivity in contrast to other atoms. Furthermore, the molecular orbitals for HOMO and LUMO were computed to check the chemical reaction characteristics of the SMS. According to HOMO-LUMO energy gap, the structure of the polycyclic aromatic hydrocarbons provided reaction sites for the reaction and played a key role in chemical bond breaking.
H3K4me3 enrichment defines neuronal age, while a youthful H3K27ac signature is recapitulated in aged neurons
Authors: Giles Katherine , Phipps Andrew , Cashion Jake , Huskins Shannon , Mercer Timothy , Robinson Mark , Woodhouse Adele , Taberlay Phillippa 
Published: March 2022

Abstract
Neurons live for the lifespan of the individual and underlie our ability for lifelong learning and memory. However, aging alters neuron morphology and function resulting in age-related cognitive decline. It is well established that epigenetic alterations are essential for learning and memory, yet few neuron-specific genome-wide epigenetic maps exist into old age. Comprehensive mapping of H3K4me3 and H3K27ac in mouse neurons across lifespan revealed plastic H3K4me3 marking that differentiates neuronal age linked to known characteristics of cellular and neuronal aging. We determined that neurons in old age recapitulate the H3K27ac enrichment at promoters, enhancers and super enhancers from young adult neurons, likely representing a re-activation of pathways to maintain neuronal output. Finally, this study identified new characteristics of neuronal aging, including altered rDNA regulation and epigenetic regulatory mechanisms. Collectively, these findings indicate a key role for epigenetic regulation in neurons, that is inextricably linked with aging.
The UK Resuscitative Endovascular Balloon Occlusion of the Aorta (REBOA) Randomized Clinical Trial (the UK-REBOA trial): Study Protocol
Authors: Jansen Jan O. , Cochran Claire , Boyers Dwayne , Gillies Katie , Lendrum Robbie , Sadek Sam , Lecky Fiona , MacLennan Graeme , Campbell Marion , Moran Chris , Brohi Karim , Morrison Jonathan J. , Tai Nigel R.M. , Harris Tim , Norrie John , Paterson Alan , Welch Nick 
Published: March 2022

Abstract
BackgroundHaemorrhage is the most common cause of preventable death after injury. REBOA is a novel technique whereby a percutaneously inserted balloon is deployed in the aorta, providing a relatively quick means of temporarily controlling haemorrhage and augmenting cerebral and coronary perfusion, until definite control of haemorrhage can be attained. The aim of the UK-REBOA trial is to establish the clinical and cost-effectiveness of a policy of standard major trauma centre treatment plus REBOA, as compared with standard major trauma centre treatment alone, for the management of uncontrolled torso haemorrhage caused by injury. Methods/DesignPragmatic, Bayesian, group-sequential, randomised controlled trial, performed in 16 major trauma centres in England. We aim to randomize 120 injured patients with suspected exsanguinating haemorrhage to either standard major trauma centre care plus REBOA, or standard major trauma centre care alone. The primary clinical outcome is 90-day mortality. Secondary clinical outcomes include 3h, 6h, and 24h mortality, in-hospital mortality, 6-month mortality, length of stay (in hospital and intensive care unit), 24h blood product use, need for haemorrhage control procedure (operation or angioembolisation), and time to commencement of haemorrhage control procedure (REBOA, operation, or angioembolisation). The primary economic outcome is lifetime incremental cost per QALY gained, from a health and personal social services perspective.DiscussionThis study, which is the first to randomly allocate patients to treatment with REBOA or standard care, will contribute high-level evidence on the clinical and cost-effectiveness of REBOA in the management of trauma patients with exsanguinating haemorrhage, and will provide important data on the feasibility of implementation of REBOA into mainstream clinical practice.Trial registrationISRCTN16184981
Fatigue in perinatal stroke is associated with resting-state functional connectivity
Authors: Wrightson James G. , Carlson Helen L. , Condliffe Elizabeth G. , Kirton Adam 
Published: March 2022

Abstract
Fatigue is prevalent in youth with perinatal stroke, but the causes are unclear. Predictive coding models of adult post-stroke fatigue suggest that fatigue may arise from dysfunction in predictive processing networks. To date, the association between fatigue and neural network connectivity in youth with perinatal stroke has not been examined. The present study examined the association between fatigue and the functional connectivity of predictive processing neural networks, measured using resting-state functional magnetic resonance imaging, in individuals with perinatal stroke. Participants who reported experiencing fatigue had weaker functional connectivity between the non-lesioned middle frontal and supramarginal gyri and between the non-lesioned intracalcarine cortex and the lesioned paracingulate cortex. In contrast, participants reporting fatigue had stronger functional connectivity between the lesioned inferior temporal gyrus and non-lesioned insula. These results suggest that fatigue in youth with hemiparetic cerebral palsy caused by perinatal stroke is associated with the functional connectivity of hubs previously associated with predictive processing and fatigue. These results suggest potential cortical and behavioral targets for the treatment of fatigue in individuals with perinatal stroke.
Role of modified nasopharyngeal oxygen therapy in apnoeic oxygenation under general anaesthesia: A single-centre, randomized controlled clinical study
Authors: Huang Shaoqiang , Geng Weilian , Chen Changxing , Chen Yaobing , Yu Xinhua 
Published: March 2022

Abstract
Apnoeic oxygenation is particularly important for patients who cannot be intubated/oxygenate after anaesthesia induction. We aimed to compare safe apnoea times between patients receiving modified nasopharyngeal oxygen therapy and those receiving high-flow nasal oxygen therapy (HFNO) following the induction of general anaesthesia.This was a single-centre, randomized controlled clinical study. Eighty-four female patients undergoing elective laparoscopic gynaecological surgery under general anaesthesia were randomly assigned to the high-flow nasal oxygen therapy group or the modified nasopharyngeal oxygen therapy group. A Kaplan–Meier survival curve was used to describe the apnoeic oxygenation time.The safe apnoea time of the patients in the Naso group was higher than that of the patients in the HFNO group (20 (19.3 to 20.0) vs. 16.5 (12.9 to 20) minutes, P < 0.05). The incidence of SpO2 < 95% in the Naso group was lower than that in the HFNO group; hazard ratio 0.3 (95% confidence interval 0.2 to 0.6, P < .0001).The modified nasopharyngeal airway which uses far less oxygen than HFNO is a convenient and effective method of apnoeic oxygenation in normal female patients. Trial registration: www.chictr.org.cn,ChiCTR2000039433；date of registration:28/10/2020
Advances of isomerizing-hydrogenating properties of CoMo catalysts supported on ASA-Al2O3
Authors: Avdeenko E. A. , Nadeina K. A. , Lushchikova A. E. , Larina T. V. , Pakharukova V. P. , Gerasimov E. Yu. , Prosvirin I. P. , Gabrienko A. A. , Vatutina Yu. V. , Klimov O. V. , Noskov A. S. 
Published: March 2022

Abstract
CoMo/Al2O3-ASA catalysts with different Al2O3/ASA ratio have been studied. The amount of ASA (Si/Al ratio 0.25 wt./wt.) varied from 0 to 100 % in the support. Supports and catalysts were characterized by low-temperature N2 adsorption-desorption, TPD-NH3, IRS of adsorbed pyridine, HRTEM, UV-vis spectroscopy, XPS, XRD, bulk crushing strength. Catalysts were tested in hydrotreating of the model FCC gasoline containing 250 ppm of sulfur from thiophene, 40 wt.% of toluene, 40 wt.% of heptane and 20 wt.% of 1-hexene. It was shown that the introduction of ASA to the support increased the amount of weak Brønsted acid sites and weak and medium Lewis acid sites. The addition of ASA changed the morphology of sulfide active component and extract Co from the composition of the CoMoS phase. It was shown that presence of more than 50 wt.% of ASA in the samples demonstrated significant changes in the selectivity of CoMo catalysts.
The authors have requested that this preprint be removed from Research Square.
Authors: Wu Song , Yuqing Li , Dewang Zhou , Kang Wu , Guanghui Zhu , Peng Guoyu , Shang Wang , Yu Lu , Zhang Lei , Zhou Houhong , Dongdong Lu , Wu Xinchen , Dongdong Tang , Ying Tang , Fangchen Wan , Ziyu Zhou , Guixiao Huang , Thiery Jean 
Published: March 2022

Abstract
The authors have requested that this preprint be removed from Research Square.
Inter-annual variation patterns of carbon footprint of farmland ecosystems in industrial provinces in China--Guangdong Province as an example
Authors: Qiao Guotong , Chen Fei , Wang Na , Zhang Dandan 
Published: March 2022

Abstract
The abstract must not include a heading. It should be no more than 200 words long and contain no references or subheadings.The sequestration of carbon by agricultural ecosystems is an important part of the world carbon cycle and plays an important role in carbon reduction in all Chinese provinces, especially industrial provinces. Taking Guangdong Province, a major industrial province, as an example, and estimating the carbon emissions, carbon sequestration, and carbon footprint of Guangdong's farmland ecosystems and analyse the inter-annual dynamics of the three, to provide a theoretical basis for the formulation of carbon reduction policies and industrial restructuring in Guangdong and other provinces with similar industrial structures in the context of the “dual carbon” target. The study shows that, over the past 20 years, the annual average carbon emissions from farmland in Guangdong Province has been 3.7624 million , with the overall variation is basically the same, and the main factor of total carbon emissions is the amount of nitrogen fertilizer applied. The overall carbon sequestration capacity of Guangdong's farmland ecosystems showed a decreasing trend, with a decrease of 10.32%, and the average annual carbon sequestration amount was 19.0363 millionand the main influencing factor of the total carbon sequestration is the economic production of paddy and sugar cane. The average annual carbon footprint of Guangdong's farmland ecosystems is 531,100, which is in a state of carbon ecological surplus, at the same time the carbon surplus and carbon footprint show a decreasing trend year by year.
Numerical simulation and experimental research of fractal suspended carrier based on nonlinear equation
Authors: Zhao Bi , Wu Yunpeng , Wan Ruyin , Yang Dongke , Zheng Zhicheng , Wan Ajun 
Published: March 2022

Abstract
The geometric structure of the suspended carrier is an important factor that directly affects the effluent quality of the moving bed biofilm reactor, and it should be a valuable mathematical solution to solve the nonlinear equation through numerical simulation and experimental research. Therefore, this study has designed and prepared a coral-shaped fractal suspension carrier based on nonlinear equations, and verify the effectiveness of the new carrier for sewage treatment through FLUENT numerical simulation and domestic sewage treatment experiments. The experimental results show that the coral-shaped fractal suspension carrier has a significant effect on the velocity, vortex distribution and gas phase distribution of the flow field in the reactor. The mass transfer dead area in the reactor is reduced, the number of vortices is significantly increased and the fractal dimension of the carrier is negatively correlated with the flow velocity and pressure drop of the fluid. After stabilization, the average removal rates of COD and NH4+-N by the reactor are 89.5% and 93.21% respectively, the effluent quality reach the national first-class A standard, and the sewage treatment performance is good. At the same time, this research provides a preliminary research basis for the method of solving nonlinear equations through numerical simulation and experimental research.
Spatial planning of eco-industrial park based on reverse logistics
Authors: Yang Qing , Wang Chen , Cai Chenyang , Liu Xingxing 
Published: March 2022

Abstract
The concept of sustainable development that people pay more and more attention to environmental protection and ecological civilization construction has become more and more popular among people. Eco-industrial parks are an effective way to achieve the dual goals of economic benefits and environmental friendliness, and promote the development of circular economy. This paper aims at the problems of disconnection between industrial chain network and spatial planning in the planning of eco-industrial parks in various countries, a spatial planning method is proposed. The specific steps of the method: firstly, introduce reverse logistics to discriminate and select industrial sub-chains to construct an industrial symbiosis chain network; then conduct suitability evaluation of residential and industrial land to form a park land layout plan; finally, use the goal achievement matrix to realize the park's spatial layout. The paper discusses the practical application of this method in conjunction with the planning of the vein industrial park in city A.