bluuebunny/crossref_metadata_2025_split huggingface dataset:
Automated staining analysis in digital cytopathology and applications
Authors: Bouyssoux Alexandre , Jarnouen Kathleen , Lallement Laetitia , Fezzani Riadh , Olivo‐Marin Jean‐Christophe 
Published: May 2022

AbstractThe progress of digital pathology in recent years has been an opportunity for the development of automated image analysis algorithms for quantitative measurements and computer aided diagnosis. With those new methods comes the need for high staining quality and reproducibility, as image analysis tools are typically more sensible to slight stain variations than trained pathologists. This article presents a method for the automated analysis of cytology slides stains specifically adapted to the challenges encountered in digital cytopathology. In particular, the variety of cell types in cytology slides, the 3D distribution of the cellular material, the presence of superposed cells and the need for independent analysis of sub‐cellular compartments are addressed. The proposed method is applied to the quantification of staining variations for quality control, resulting from changes in the staining protocol such as reagent immersion time or a reagent change. Another demonstrated application is the selection of staining protocol parameters that maximize the visible details in nucleus. Finally the analysis pipeline is also used to compare different stain normalization algorithms on digital cytology slides. Code available at: https://gitlab.com/vitadx/articles/automated_staining_analysis.
Fulminant necrotizing eosinophilic myocarditis after COVID‐19 vaccination survived with mechanical circulatory support
Authors: Kimura Mitsukuni , Hashimoto Toru , Noda Eri , Ishikawa Yusuke , Ishikita Akihito , Fujino Takeo , Matsushima Shouji , Ide Tomomi , Kinugawa Shintaro , Nagaoka Kazuhiro , Ushijima Tomoki , Shiose Akira , Tsutsui Hiroyuki 
Published: May 2022

AbstractA 69‐year‐old man was hospitalized for heart failure 7 days after coronavirus disease 2019 (COVID‐19) mRNA vaccination. Electrocardiography showed ST‐segment elevation and echocardiography demonstrated severe left ventricular dysfunction. Venoarterial extracorporeal membrane oxygenation and Impella 5.0 were instituted because of cardiogenic shock and ventricular fibrillation. Endomyocardial biopsy demonstrated necrotizing eosinophilic myocarditis (NEM). Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV2) PCR test was negative. He had no infection or history of new drug exposure. NEM was likely related to COVID‐19 vaccination. He was administered 10 mg/kg of prednisolone following methylprednisolone pulse treatment (1000 mg/day for 3 days). Left ventricular function recovered and he was weaned from mechanical circulatory support (MCS). Follow‐up endomyocardial biopsy showed no inflammatory cell infiltration. This is the first report of biopsy‐proven NEM after COVID‐19 vaccination survived with MCS and immunosuppression therapy. It is a rare condition but early, accurate diagnosis and early aggressive intervention can rescue patients.
Copper/Iodine‐Catalyzed Hydroxyamination of Alkenyl Keto Oximes Using DMSO as the Oxygen Atom Source and Medium
Authors: Yin Xiao‐Qiu , Deng Wei , Xiang Jian‐Nan 
Published: May 2022

AbstractA new copper/I2‐catalyzed hydroxyamination of alkenes of unsaturated keto oximes with DMSO as the hydroxy oxygen atom source and medium for assembling 2‐(2‐hydroxyalkyl)‐3,4‐dihydro‐2H‐pyrrole 1‐oxides is described. Mechanistic studies suggest that the reaction is terminated by a single electron oxidation and subsequent nucleophilic reaction.
Improved Synthesis Strategy for N‐Methoxy‐1,3‐oxazinane Nucleic Acids (MOANAs)
Authors: Wallin Josefiina , Lönnberg Tuomas 
Published: May 2022

AbstractDependence of the hydrolysis rate of a series of N‐methoxy‐2‐phenyl‐1,3‐oxazinanes on the Hammett substituent constant of the substituent of the phenyl ring was determined, yielding a reaction constant ρ=−1.40±0.05. Based on this information, 4‐(benzoyloxy)benzaldehyde was selected as a protecting group for a new (2R,3S)‐4‐(methoxyamino)butane‐1,2,3‐triol phosphoramidite building block. The yield of the preparation of this building block as well as its coupling in automated oligonucleotide synthesis were greatly improved compared to the method reported previously. The 2‐[4‐(benzoyloxy)phenyl]‐1,3‐oxazine protection persisted throughout the synthesis of short oligonucleotides but was rapidly removed when the oligonucleotides were released from solid support and dissolved in water.
Effect of diagnostic labelling on management intentions for non‐specific low back pain: A randomized scenario‐based experiment
Authors: O'Keeffe Mary , Ferreira Giovanni E. , Harris Ian A. , Darlow Ben , Buchbinder Rachelle , Traeger Adrian C. , Zadro Joshua R. , Herbert Rob D. , Thomas Rae , Belton Joletta , Maher Chris G. 
Published: May 2022

AbstractBackgroundDiagnostic labels may influence treatment intentions. We examined the effect of labelling low back pain (LBP) on beliefs about imaging, surgery, second opinion, seriousness, recovery, work, and physical activities.MethodsSix‐arm online randomized experiment with blinded participants with and without LBP. Participants received one of six labels: ‘disc bulge’, ‘degeneration’, ‘arthritis’, ‘lumbar sprain’, ‘non‐specific LBP’, ‘episode of back pain’. The primary outcome was the belief about the need for imaging.ResultsA total of 1375 participants (mean [SD] age, 41.7 years [18.4 years]; 748 women [54.4%]) were included. The need for imaging was rated lower with the labels ‘episode of back pain’ (4.2 [2.9]), ‘lumbar sprain’ (4.2 [2.9]) and ‘non‐specific LBP’ (4.4 [3.0]) compared to the labels ‘arthritis’ (6.0 [2.9]), ‘degeneration’ (5.7 [3.2]) and ‘disc bulge’ (5.7 [3.1]). The same labels led to higher recovery expectations and lower ratings of need for a second opinion, surgery and perceived seriousness compared to ‘disc bulge’, ‘degeneration’ and ‘arthritis’. Differences were larger amongst participants with current LBP who had a history of seeking care. No differences were found in beliefs about physical activity and work between the six labels.Conclusions‘Episode of back pain’, ‘lumbar sprain’ and ‘non‐specific LBP’ reduced need for imaging, surgery and second opinion compared to ‘arthritis’, ‘degeneration’ and ‘disc bulge’ amongst public and patients with LBP as well as reducing the perceived seriousness of LBP and enhancing recovery expectations. The impact of labels appears most relevant amongst those at risk of poor outcomes (participants with current LBP who had a history of seeking care).
Lumped spring model parameters of RC frame elements for seismic performance assessment
Authors: Huang Xu , Kim Sang Hak , Kwon Oh‐Sung 
Published: May 2022

AbstractThis study presents lumped spring model parameters for nonlinear seismic analysis of reinforced concrete (RC) frame structures. The modified Ibarra‐Medina‐Krawinkler (M‐IMK) hysteresis model is used as a lumped spring to simulate the inelastic behaviour of a RC frame element. The influence of loading protocols on the calibration of model parameters is investigated and compared with other hysteresis models, such as the original IMK and Bouc‐Wen‐Baber‐Noori (BWBN) models. Less dependent on the loading protocol used for model identification, the parameters of the modified IMK hysteresis model are calibrated to model a database of 383 rectangular RC columns. To simplify the calibration process, the model parameters that define the monotonic response are determined based on code and empirical equations, while the parameters that control the hysteretic degradations are calibrated against the experimental results. The calibrated model parameters are used to develop regression equations for the model parameters based on physical variables, such as loading, dimensions, and material properties. It is found that the model parameters obtained from the experimental calibration and regression equations generate similar hysteresis curves. The performance of the lumped spring model to nonlinear time history analysis of RC structures subjected to earthquakes is also evaluated through a series of pseudo‐dynamic hybrid simulations.
A facile one‐step solution synthesis of Cs2SnI6−xBrx using less‐toxic methanol solvent for application in dye‐sensitized solar cells
Authors: Qamar Samina , Sultan Muhammad , Akhter Zareen , Ela Sule Erten 
Published: May 2022

SummaryCs2SnX6 (X = I, Br, and Cl), a vacancy‐ordered double perovskite, has recently emerged as a promising lead‐free perovskite for optoelectronic applications. The low quality of solution‐processed Cs2SnX6 perovskites, on the other hand, precludes further improvement of their performance in the devices. In this work, we developed a facile one‐step solution strategy for synthesizing high‐quality Cs2SnI6−xBrx material with the less‐toxic methanol solvent. A series of Cs2SnI6−xBrx perovskites was synthesized by carefully tuning each stage of the process and using thorough structural and optical characterizations as feedback. We identified two critical parameters that affect the quality of perovskite material through this detailed characterization: the reactant ratio and the annealing temperature. The optimal precursor ratio for the synthesized perovskite was determined to be 1:1 with an annealing temperature of 100°C. Leveraging this, we investigated the optimized perovskite material as a hole transport material (HTM) in a dye‐sensitized solar cell (ss‐DSSC) and achieved an outstanding PCE of 3.2% without using any modifiers. We envisage that our findings may open the door for the growth of nonhazardous synthesis approaches for Sn‐based optoelectronic devices.Novelty StatementThe preparation methods and high costs associated with the organic HTMs and the use of toxic solvents are the major obstacles to developing efficient materials for photovoltaic applications. With the possibility of commercialization of solution‐processable solar cells, it is critical to find less hazardous perovskite formation approaches. Leveraging this, we developed a facile one‐step solution method and investigated the potential of Cs2SnI6−xBrx perovskite as a promising hole transport material (HTM) for solid‐state dye‐sensitized solar cell (ss‐DSSC).
Thermal decomposition behavior of ammonium perchlorate organic waste liquid by pyrolysis coupled with nonthermal plasma
Authors: Gao Ningbo , Ma Yan , Quan Cui , Wu Shixi , Ge Zhiqiang , Miskolczi Norbert 
Published: May 2022

SUMMARYThermal decomposition behavior of ammonium perchlorate organic waste liquid by pyrolysis coupled with nonthermal plasma has rarely been reported. This paper studies the effect of dielectric barrier discharge (DBD) plasma on ammonium perchlorate organic waste liquid. First, the ammonium perchlorate organic waste liquid was investigated by thermogravimetry, gas chromatography‐mass spectrometry, and ion chromatography analyses and, then, was pyrolyzed in the two‐stage fixed bed reactor with plasma discharge device. At low temperature, the existence of DBD plasma had a good contribution to the gas production of raw liquid. The degradation rate of perchlorate reached 99%. While steam to oil ratio increased, the gas yield enhanced. The gas yield of raw liquid was 3.62 mmol g−1 with steam (only 0.67 mmol g−1 without steam). The hydrogen concentration is about 40% at different temperatures and gas can be used as syngas to achieve low carbon emission and for energy saving.
Analysis and assessment of a novel organic flash Rankine cycle (OFRC) system for low‐temperature heat recovery
Authors: Wang Qi , Macián‐Juan Rafael , Li Dantong 
Published: May 2022

AbstractIn this paper, a novel organic flash Rankine cycle (OFRC) system for low‐temperature heat recovery is analyzed and optimized using the 3E (energy, exergy, and economic) analysis method and particle swarm optimization algorithm, respectively. Five environmentally friendly organic fluids and three typical heat source conditions are simultaneously discussed during the parametric analysis and optimization process, to obtain a comprehensive understanding of the thermo‐economic characteristics of this novel system. The main analysis results show that the biggest exergy loss of the OFRC system is caused by the condenser, followed by the evaporator. About 70% of the specific power cost is caused by the capital investment of the system, and more than 60% of the capital investment is spent on purchasing the high‐pressure and low‐pressure expanders. Under the same operating conditions, the working fluids with high critical temperatures can achieve higher cycle thermal efficiency and lower specific power costs than those with low critical temperatures. The optimization results show that the OFRC system is able to achieve a better thermodynamic performance than the organic Rankine cycle (ORC) and organic flash cycle (OFC) systems, and when the heat source's inlet temperature is set to 100°C, 120°C, and 140°C, R245fa, R290, and R152a are, respectively, recommended as the best working fluid for the OFRC system. Besides this, it is found that the OFC system has the worst thermo‐economic performance, and the ORC system can achieve the lowest specific power cost. A new finding is that, for all three systems, the higher the critical temperature of the working fluid, the lower the specific power cost of the system.
Bipolar fuzzy information‐based PROMETHEE‐based outranking scheme for mitigating vampire attack in wireless sensor networks
Authors: Arunachalam Rajesh , Perumal Esther Rani 
Published: May 2022

AbstractThe sensor nodes comprising sensing devices, small processing units, and battery, cooperate in wireless sensor networks (WSNs) for gathering potential factors that aids in achieving significant decision‐making processes in deployed applications. WSNs are vulnerable to security threats due to their open nature, availability characteristics, and lack of energy, resulting in a diversified number of security attacks. Among the security attacks, vampire attack is the serious threat as they drain the energy of nodes, which in turn crumbles the network lifetime and energy stability in WSNs. In this article, Bi‐Polar Information‐Based Preference Ranking Organization Method for Enrichment of Evaluations (PROMETHEE)‐based outranking scheme is proposed for detecting and isolating vampire attacks to improve throughput with minimized energy consumptions and delay for prolonging lifetime. This proposed BPFI‐POR scheme used bipolar information that facilitates an asymmetrical association between two decision making factors that influences the discrimination and selection of genuine nodes from vampire nodes during the routing process. It aids in characterizing precise and vague information through bipolar fuzzy linguistic terms that has the maximized probability of being represented as trapezoidal bipolar fuzzy numbers. It estimated the cooperation of intermediate sensor nodes' based on trapezoidal bipolar fuzzy numbers for determining their preference or selection using criteria that could be influenced during the routing process. It also used the ranking function for accessing the alternatives through crisp real preferences with entropy weighting information responsible for attributes weight computation. The simulation results of the BPFI‐POR scheme confirmed better throughput, detection time with minimized energy consumptions and latency on par with the competitive algorithms.
An optimization‐based CCUS source‐sink matching model for dynamic planning of CCUS clusters
Authors: Wu Qian , Lin Qianguo , Yang Qiang , Li Yang 
Published: May 2022

AbstractCarbon capture, utilization and storage (CCUS) is a critical technology option in achieving large‐scale CO2 mitigation for power and industrial sectors. A full‐chain CCUS cluster could be formed based on numerous scattered capture sources and one or more storage sites connected by a pipeline network. Reasonable source‐sink matching planning for a full‐chain CCUS cluster could substantially reduce the system overhead. However, most of the previous studies could hardly address the dynamic source‐sink matching planning problem of a full‐chain CCUS cluster with multiple types of emission sources and sinks during multiple periods. Therefore, the objective of this study is to investigate an optimized source‐sink matching scheme within a CCUS cluster through developing an optimization‐based CCUS source‐sink matching model. The proposed model is based on multistage mixed integer linear programming techniques with the objective of least‐cost strategy; thus, it can deal with dynamics of capacity expansion associated with CCUS activities. The developed method is then applied to a CCUS cluster facing long‐term dynamic planning issues. The modeling results suggest that the optimization‐based CCUS source‐sink matching model is applicable in reflecting dynamics of time, scale and location of CO2 capture, transportation and storage within a CCUS cluster. The obtained solutions can provide decision bases for formulating an optimal planning scheme of a full‐chain CCUS cluster under evolving reduction targets or constraints. © 2022 Society of Chemical Industry and John Wiley & Sons, Ltd.
Rural credit and agricultural production: Empirical evidence from Brazil
Authors: Nascimento Daniel Henrique , Carrasco‐Gutierrez Carlos Enrique , Schneid Tessmann Mathias 
Published: May 2022

AbstractThis article examines the long‐ and short‐run effects of rural credit on the gross value added of agricultural output in Brazil. We apply the dynamic vector error correction model (VECM) to the estimation and testing. The main finding is that there is a positive long‐run relationship between agricultural sector production and loans from financial institutions to the agricultural sector. The long‐run elasticity estimated was 0.44, implying that an increase of 1% in rural credit leads to a 0.44% increase in the agricultural sector's GDP. This result supports the policy of rural credit as a crucial institutional instrument to strengthen the agricultural sector and as an important factor to boost the country's economic growth.
Barriers to the implementation of quality maternal death reviews in health districts in Burkina Faso
Authors: Congo Boukaré , Yaméogo Wambi M.E. , Millogo Tieba , Compaoré Rachidatou , Tougri Halima , Ouédraogo Charlemagne M.R. , Kouanda Seni 
Published: May 2022

AbstractObjectiveTo identify barriers to the implementation of maternal death reviews in health districts in Burkina Faso.MethodsWe conducted a multiple case study in seven health facilities chosen by contrasted purposive sampling. Sampling criteria were based on intrahospital maternal mortality rates and the location of the health facility. Data collection was conducted from April 27 to May 30, 2015, using structured and semistructured interviews and data extraction from source documents. Data were analyzed using a thematic approach.ResultsBarriers to quality maternal death reviews identified were primarily implementation conditions, including poor skills and motivation of healthcare personnel, low interest in quality of care, lack of suitable equipment, insufficient coordination and collaboration between health services, insufficient monitoring, and weakness in programming and conducting the reviews.ConclusionBarriers to achieving quality maternal death reviews remain numerous at the operational level of the health system. Taking steps to remove these barriers is key to improving the quality of maternal death reviews and childbirth outcomes in Burkina Faso.
Safe recovery after cesarean in rural Africa: Technical consensus guidelines for post‐discharge care
Authors: Kateera Fredrick , Hedt‐Gauthier Bethany , Luo Amy , Niyigena Anne , Galvin Grace , Hakizimana Sadoscar , Molina Rose L. , Boatin Adeline A. , Kasonde Prisca , Musabeyezu Juliet , Ngonzi Joseph , Riviello Robert , Semrau Katherine , Sayinzoga Félix 
Published: May 2022

AbstractDespite increasing cesarean rates in Africa, there remain extensive gaps in the standard provision of care after cesarean birth. We present recommendations for discharge instructions to be provided to women following cesarean delivery in Rwanda, particularly rural Rwanda, and with consideration of adaptable guidelines for sub‐Saharan Africa, to support recovery during the postpartum period. These guidelines were developed by a Technical Advisory Group comprised of clinical, program, policy, and research experts with extensive knowledge of cesarean care in Africa. The final instructions delineate between normal and abnormal recovery symptoms and advise when to seek care. The instructions align with global postpartum care guidelines, with additional emphasis on care practices more common in the region and address barriers that women delivering via cesarean may encounter in Africa. The recommended timeline of postpartum visits and visit activities reflect the World Health Organization protocols and provide additional activities to support women who give birth via cesarean. These guidelines aim to standardize communication with women at the time of discharge after cesarean birth in Africa, with the goal of improved confidence and clinical outcomes among these individuals.
Disruption of the MICOS complex leads to an aberrant cristae structure and an unexpected, pronounced lifespan extension in Podospora anserina
Authors: Warnsmann Verena , Marschall Lisa‐Marie , Meeßen Anja C. , Wolters Maike , Schürmanns Lea , Basoglu Marion , Eimer Stefan , Osiewacz Heinz D. 
Published: May 2022

AbstractMitochondria are dynamic eukaryotic organelles involved in a variety of essential cellular processes including the generation of adenosine triphosphate (ATP) and reactive oxygen species as well as in the control of apoptosis and autophagy. Impairments of mitochondrial functions lead to aging and disease. Previous work with the ascomycete Podospora anserina demonstrated that mitochondrial morphotype as well as mitochondrial ultrastructure change during aging. The latter goes along with an age‐dependent reorganization of the inner mitochondrial membrane leading to a change from lamellar cristae to vesicular structures. Particularly from studies with yeast, it is known that besides the F1Fo‐ATP‐synthase and the phospholipid cardiolipin also the “mitochondrial contact site and cristae organizing system” (MICOS) complex, existing of the Mic60‐ and Mic10‐subcomplex, is essential for proper cristae formation. In the present study, we aimed to understand the mechanistic basis of age‐related changes in the mitochondrial ultrastructure. We observed that MICOS subunits are coregulated at the posttranscriptional level. This regulation partially depends on the mitochondrial iAAA‐protease PaIAP. Most surprisingly, we made the counterintuitive observation that, despite the loss of lamellar cristae and of mitochondrial impairments, the ablation of MICOS subunits (except for PaMIC12) leads to a pronounced lifespan extension. Moreover, simultaneous ablation of subunits of both MICOS subcomplexes synergistically increases lifespan, providing formal genetic evidence that both subcomplexes affect lifespan by different and at least partially independent pathways. At the molecular level, we found that ablation of Mic10‐subcomplex components leads to a mitohormesis‐induced lifespan extension, while lifespan extension of Mic60‐subcomplex mutants seems to be controlled by pathways involved in the control of phospholipid homeostasis. Overall, our data demonstrate that both MICOS subcomplexes have different functions and play distinct roles in the aging process of P. anserina.