bluuebunny/crossref_metadata_2025_split huggingface dataset:
Basic Research on Rockburst Control Technology for Deep Well Filling of Municipal Solid Waste
Authors: Zhou Chao , Zhu Sitao , Li Jiajie , Jiang Fuxing , Gao Yongtao , Qu Xiaocheng , Ji Maowei , Wei Quande 
Published: November 2022

Abstract
Given the scarcity of raw materials for rockburst prevention in filling mining and the lack of space for disposal of large amount of municipal waste, the feasibility of preparing filling materials for rockburst mines from stale waste was investigated by laboratory tests and theoretical analysis. On this basis, the process of preparing filling materials from stale garbage was proposed, and corresponding equipment were developed to prepare stale garbage filling mass. According to the characteristics and uses of the stale waste filling materials, two processes of volume filling and strength filling are proposed, and the key technology of stale garbage filling to control rockburst was designed. The following conclusions were drawn: stale garbage can be made into mine filling material because of its composition, strength, and shape. The process of preparing mine filling materials from obsolete waste includes crushing, screening, compression, and packaging. The equipment suitable for the process includes crushing-screening, compression-forming, and sealing-packaging integrated equipment. The equipment has realized effective screening, compression, and bulk packaging of stale garbage, so that the stale garbage filling mass can meet the requirements of environmental protection and strength. Strength filling is a filling method that uses the strength of stale garbage filling mass to protect the overlying strata from or less damage, thereby reducing the stress concentration in the coal face and reducing the risk of rockburst occurring. Volume filling mainly depends on the volume of the filling mass, with the main purpose of reducing the stress concentration in the roadway surrounding rock. The rockburst mine filling technology of stale garbage is support track filling technology and bag filling technology, and the deep well sealing of stale garbage is block stacking technology. The deep well filling mining key technologies provide a new approach to against rockburst and treat large amounts of municipal waste.
Seroprevalence of four endemic human coronaviruses antibodies among Filipino children and their cross-reactivity and neutralization capacity against SARS-CoV-2
Authors: Sayama Yusuke , Okamoto Michiko , Saito Mayuko , Saito-Obata Mariko , Tamaki Raita , Joboco Christine Dahlia , Lupisan Socorro , Oshitani Hitoshi 
Published: November 2022

Abstract
Four endemic human coronaviruses (HCoV), HCoV-229E, HCoV-NL63, HCoVHKU1, and HCoV-OC43, are closely related to SARS-CoV-2. These coronaviruses are known to infect humans living in temperate areas, including children under 5 years old; however, the seroprevalence of anti-HCoV antibodies among children in tropical areas, including the Philippines, remains unclear. This study aimed to assess the prevalence of antibodies against endemic HCoVs among Philippine children and to determine the cross-reactivity and neutralization of these antibodies against SARS-CoV-2. A total of 315 serum samples collected from 2015 to 2018 in Biliran island, Philippines, were tested for the presence of antibodies against four HCoVs and SARS-CoV-2 using recombinant spike proteins. Cross-reactivity to and neutralization of SARS-CoV-2 were also investigated. The seroprevalence of the four HCoVs was 63.8% for HCoV-229E, 71.4% for HCoV-NL63, 76.5% for HCoV-HKU1, and 83.5% for HCoV-OC43. Age group analysis indicated that seropositivity to all HCoVs reached 80% by 2–3 years of age. While 69/315 (21.9%) of the samples showed crossreactivity to SARS-CoV-2, almost no neutralization against SARSCoV-2 was detected. The high anti-HCoVs antibody levels at an early age suggest that there is earlier and higher prevalence of HCoV infections in the Philippines. Cross-reactive samples against SARS-CoV-2 indicated low neutralization capability.
Indole-carbohydrazide linked phenoxy-1,2,3-triazole-N-phenylacetamide derivatives as potent α-glucosidase inhibitors: Design, synthesis, in vitro α-glucosidase inhibition, and computational studies
Authors: Emadi Mehdi , Mosavizadeh-Marvest Fahimeh , Asadipour Ali , Pourshojaei Yaghoub , Hosseini Samanesadat , Mojtabavi Somayeh , Faramarzi Mohammad Ali , Larijani Bagher , Mohammadi-Khanaposhtani Maryam , Mahdavi Mohammad 
Published: November 2022

Abstract
Background
A new series of indole-carbohydrazide-phenoxy-1,2,3-triazole-N-phenylacetamide hybrids 11a-o was designed based on molecular hybridization of the active pharmacophores of the potent α-glucosidase inhibitors. These compounds were synthesized and evaluated against α-glucosidase.
Methods
The fifteen various derivatives of indole-carbohydrazide-phenoxy-1,2,3-triazole-N-phenylacetamide scaffold were synthesized, purified, and fully characterized. These derivatives were evaluated against yeast α-glucosidase in vitro and in silico. ADMET properties of the most potent compounds were also predicted.
Results
All new derivatives 11a-o (IC50 values = 6.31 ± 0.03–49.89 ± 0.09 µM) are excellent α-glucosidase inhibitors in comparison to acarbose (IC50 value = 750.0 ± 10.0 µM) that was used as a positive control. Representatively, (E)-2-(4-((4-((2-(1H-indole-2-carbonyl)hydrazono)methyl) phenoxy)methyl)-1H-1,2,3-triazol-1-yl)-N-(4-methoxyphenyl)acetamide 11d with IC50 = 6.31 µM against MCF-7 cells, was 118.8-times more potent than acarbose. This compound is an uncompetitive inhibitor against α-glucosidase and showed the lowest binding energy at the active site of this enzyme in comparison to other potent compounds. Furthermore, computational calculations predicted that compound 11d can be an orally active compound.
Conclusion
According to obtained data, compound 11d can be a valuable lead compound for further structural development and assessments to obtain effective and potent new α-glucosidase inhibitors.
Healthcare Attention among Diabetic Patients in a Tertiary Care Centre in Tamil Nadu, India
Authors: Sivasubramanian Barath Prashanth , Ruquaya A. K. Samina , Ravikumar Diviya Bharathi , Palit Sandhya Rupa , Gani A. R. Parveen , Krishnaswamy Vanitha 
Published: November 2022

Abstract
Introduction: Diabetes initially causes generalized or nonspecific symptoms which are often not given importance. Patients require healthcare attention to reduce the comorbidities that can develop. Since diabetes is prevalent in India, there is a National Programme for Diabetes that provides free diagnostics, drugs, and health promotion through behavior change but patients still develop complications. Objectives: The aim of the study is to assess participants’ awareness of the diabetic diet, foot care, regular eye checkup, and complications of diabetes, as well as adherence to a diabetic diet, physical exercises, drug therapy, and timely follow-ups. Methods: A descriptive cross-sectional study was done among 156 Diabetic individuals who had at least three previous visits to the Non-Communicable Disease clinic. Seriously ill patients were excluded. Pretested semi-structured questionnaire was used. The data collected was documented in MS Excel and analyzed using relevant statistical tests in EPI INFO v7.2.5 Results: Of the 156 participants, the mean age was 57.1 years and 48.7% had Diabetes for > 5 years. 85.9% of participants had low awareness of self-care and complications. 49.4% of the participants had lightheadedness as their initial reason that lead to the investigation of diabetes and 14.1% were diagnosed during regular check-ups. 39.1% of participants did regular physical exercises, and 32.7% followed the diabetic diet. 45.5% and 73.1% of the participants were overweight and had hypertension, respectively. 36.5% missed one or two doses of medication and 19.2% had changed medication dosage on their own. 78.9% made their preceding visits on the recommended dates. Conclusion: Most participants’ adherence to drug therapy and timely follow-up is high. But the participants’ had low awareness of self-care and complications, as well as low adherence to diet and exercise. This highlights the need to improve healthcare attention among diabetics.
Real-world assessment of drug related problems by medication reviews at the emergency department in older patients living with frailty
Authors: Nuland Merel van , Butterhoff Madelon , Verwijmeren Karin , Berger Florine , Hogervorst Vera M. , de Jonghe Annemarieke , Linden Paul van der 
Published: November 2022

Abstract
Background
Older patients are at risk of drug related problems (DRPs), potentially leading to emergency department (ED) visits. Identifying DRPs with medication reviews is typically evaluated in restrictive clinical studies and not in a ‘real-world’ setting with organizational challenges and time-pressure. This study aims to assess the number of DRPs at the ED in older patients living with frailty, and to determine the acceptance rate of medication recommendations among physicians and the general practitioner. Additionally, practical recommendations are provided for implementing a medication review program.
Methods
A retrospective observational study was performed in patients ≥ 70 years living with frailty who visited the ED at Tergooi Medical Center. Medication reviews were conducted to identify and classify DRPs as part of a larger geriatric assessment. Also, the acceptance rate of given recommendations was assessed.
Results
A total of 356 ED visits were included. The mean age of patients was 83 years. About 76% of patients had at least one DRP. In total, 548 DRPs were identified with a mean of 1.5 DRP per patient. The acceptance rate of medication recommendations in admitted patients was 55%, and 32% among general practitioners/elderly care specialists in discharged patients.
Conclusions
Our results show that medication reviews lead to better assessment of DRPs at the ED. The acceptance rate was substantially higher in admitted patients compared to discharged patients. Results of our study reflect the real-life setting of conducting medication reviews at the ED for older patients living with frailty.
Is Everything Correct? The Formation Enthalpies Estimation and Data Revision of Nitrates and Perchlorates Salts
Authors: Khakimov Dmitry V. , Pivina Tatyana S. 
Published: November 2022

Abstract
Based on various calculation methods, the enthalpies of formation for a number of salts of nitric and perchloric acids were estimated. Relationships between the thermochemical characteristics of salts depending on various cations are considered. Calculations have been made and the efficiency of using a number of quantum-chemical methods in estimating the formation enthalpy of compounds in the gas phase has been analyzed. Based on a combination of quantum chemistry methods and Atom-Atom Potentials, the crystal structure of salts was simulated and the enthalpy of sublimation was estimated for subsequent use in calculations by the recently developed MICCM method. This method surpasses all the most commonly used calculation schemes in terms of accuracy in estimating the enthalpies of salt formation. Among the compounds considered, the calculations of the salts enthalpies of three amino-1,2,4-triazoles showed a significant discrepancy with the experimental data.
Prevalence and pathology of paratuberculosis in cattle slaughtered at ELFORA export abattoir Bishoftu, central Ethiopia
Authors: Mohammed Temesgen , Mamo Gezahegne , Zewudi Aboma , Sirak Asegedech , Gumi Balako , Ameni Gobena 
Published: November 2022

Abstract
Background
Paratuberculosis, caused by Mycobacterium avium subsp. paratuberculosis (MAP), is a chronic progressive granulomatous enteritis affecting ruminants and a wide variety of domestic and wild life species worldwide. Although there are reports of clinical cases of paratuberculosis in different veterinary clinics in Ethiopia, there is no epidemiological data on this disease in Ethiopia. Thus, this study was formulated to investigate the prevalence and pathology of paratuberculosis in apparently healthy cattle slaughtered at ELFORA export abattoir. Small intestines and associated mesenteric lymph nodes of 400 cattle slaughtered at ELFORA export abattoir were examined for gross pathological lesions of paratuberculosis. The diagnosis was confirmed by histopathological examination. The microscopic lesions were then graded on the basis of the type and amount of cellular infiltrations.
Results
When the intestines and the corresponding lymph nodes were examined in the slaughterhouses the prevalence of paratuberculosis gross lesions was 11.25% (45/400). The gross lesions were characterized by intestinal thickening, mucosal corrugations and enlargement of associated mesenteric lymph nodes. Histopathologically 17.9% (8/45) of the cattle with gross lesion were found to have microscopic lesion compatible with paratuberculosis. The microscopic lesions were characterized by granuloma of different grades. The grading of the microscopic lesions revealed 2 animals had grade I, 4 grade II and 2 grade III lesions.
Conclusions
This study indicated the occurrence of paratuberculosis in cattle of Ethiopia using gross pathological examination of tissue samples. However, gross pathology alone cannot be used as a diagnostic tool and the findings stress the importance of a careful histopathological examination for confirmation of the gross lesions. We conclude that paratuberculosis is prevalent in cattle of Ethiopia for the first time and the result warrants for further nationwide study of the disease to establish its epidemiology and economic significance.
Simulating single-photon detector array sensors for depth imaging
Authors: Scholes Stirling , Mora-Martin German , Zhu Feng , Gyongy Istvan , Soan Phil , Leach Jonathan 
Published: November 2022

Abstract
Single-Photon Avalanche Detector (SPAD) arrays are a rapidly emerging technology. These multi-pixel sensors have single-photon sensitivities and pico-second temporal resolutions thus they can rapidly generate depth images with millimeter precision. Such sensors are a key enabling technology for future autonomous systems as they provide guidance and situational awareness. However, to fully exploit the capabilities of SPAD array sensors, it is crucial to establish the quality of depth images they are able to generate in a wide range of scenarios. Given a particular optical system and a finite image acquisition time, what is the best-case depth resolution and what are realistic images generated by SPAD arrays? In this work, we establish a robust yet simple numerical procedure that rapidly establishes the fundamental limits to depth imaging with SPAD arrays under real world conditions. Our approach accurately generates realistic depth images in a wide range of scenarios, allowing the performance of an optical depth imaging system to be established without the need for costly and laborious field testing. This procedure has applications in object detection and tracking for autonomous systems and could be easily extended to systems for underwater imaging or for imaging around corners.
Prevalence and Categorization of Antibiotic Drug Related Problems and the Effects on Outcomes of Neonates With Sepsis: A prospective observational study
Authors: Moftian Nazila , Rezaei-Hachesu Peyman , Esfandiari Atefeh , Soltani Taha Samad , Tabib Mohammad Saleh , Mirnia Kayvan 
Published: November 2022

Abstract
Background: Antibiotics are central to the initial treatment of sepsis in neonatal intensive care units (NICU). But, due to Drug-Related problems (DRP), many neonates do not experience the expected effects of treatment. The objective of this study was to identify the DRPs associated with antibiotics, as well as their associated factors and effects on outcomes, in neonates diagnosed with sepsis within 72 hours of birth.
Methods: A prospective observational study involving 223 neonates with sepsis admitted to the NICU was conducted from 1 June to 30 November 2021. A panel of experts designed and validated the data collection form, comprising five sections: neonatal, maternal, delivery, lab finding, and pharmacological treatment information. Logistic regression was used to establish the DRPs determinants. A p-value< 0.05 was deemed statistically significant. The Kaplan–Meier method was used to compare neonates’ survival rates with and without DRPs.
Results: Ampicillin (70.2%) and Gentamicin (50,5%) were the most frequently used antibiotics. At a rate of 39.91%, 129 DRPs of antibiotics were identified in 89 neonates [95% CI: 32.8–47.01]. Ineffective antibiotics (36.4%) and excessive dosages (24%) were the most common DRPs identified. Two or more antibiotics exposure [AOR=3.8, 95%CI [0.8-12.8], p=0.031] and diarrhea [AOR=1.8, 95%CI [1.2-2.4], p=0.014) were determined of DRPs. Significant outcomes of antibiotic DRPs included persistent infection, septic shock, new infection focus, and mortality within 30 days due to any cause.
Conclusion: The effectiveness of drug therapy is impacted by the use of inappropriate antibiotics and dose selection. Two or more antibiotics exposure and diarrhea were associated with an increased risk of DRPs and unfavorable outcomes.
Facile, One-pot Synthesis of S-doped Carbon Quantum Dots for Hydrogen Peroxide Detection
Authors: Palakulam Joyal Jain , O Jibin P , Kuttappan Anupama , Paul Tessy , Aippunny Ann Mary Kakkassery 
Published: November 2022

Abstract

ABSTRACT
We have developed a green, facile and economical route to synthesise luminescent carbon quantum dots from pulp free juice of Citrus limon in ethylene glycol. The obtained graphitic carbon dots with an average size of 3 nm exhibits strong UV absorption. Dependence of excitation wavelength on blue emitting carbon dots is investigated. This spectral behaviour remains unchanged with sulphur doping in carbon dots. They show good biocompatibility while inhibiting the growth of DLA cancerous cells. Moreover optical properties of S-doped carbon quantum dots are utilised to detect hydrogen peroxide with a detection limit of 0.49 mM.
GRAPHICAL ABSTRACT
The Mortality Predictors in Patients with COVID-19 referred to the Emergency Department of Shahid Mohammadi Hospital in Bandar Abbas city in 2019
Authors: Jabbari Latife , AzizKhani Leila , Shamsipour Saman , Hayati Saeed 
Published: November 2022

AbstractBackground and aim: Identifying the predictors of Mortality in COVID-19 is a way of identifying high-risk patients. Previous studies reported comorbidities and old age as the essential components of Covid-19 Mortality. The present study aims to determine the predictors of mortality in patients with COVID-19 referred to the emergency department. Materials and method The present descriptive-analytical study was conducted retrospectively on patients with confirmed COVID − 19 referred to the emergency department of Shahid Mohammadi Hospital in Bandar Abbas in 2019. Patient information, including age, gender, underlying disease, history of smoking, clinical symptoms, type of treatment, and laboratory findings, were extracted from the covid registry. Results In this study, 2478 patients with covid 19 were examined. The average age of the study subjects was 52.57 ± 16.41 years. Among them, 1371 people (55.3%) were men. The most common clinical symptom of the patients was shortness of breath (63.2%), and the most common underlying disease was hypertension (24.3%). 16.9% of examined covid 19 patients died. According to the results of multiple logistic regression analysis, with each 1-year increase in the age of the patients, the chance of death increased by 4.7% (P < 0.001). In addition, dyspnea increased the probability of death by 2.4 times, hypertension by 1.6 times, ischemic heart disease by 1.7 times, dyslipidemia by 3.6 times, stroke by 2.9 times, and malignancy by 2.2 times. (P < 0.05). The most important predictor of Mortality was CRP 3+, which increased the probability of Mortality in Covid-19 patients by almost 25 times (OR = 25.338, with a 95% confidence interval in the range of 1.978 to 324.668, P = 0.013). In addition, with each unit increase in ESR, the chance of death in patients increased by 3.3% (P < 0.001). On the other hand, among the clinical symptoms, anorexia (OR = 0.711, with a 95% confidence interval in the range of 0.506 to 0.999, P = 0.050) and receiving Macrolides (OR = 0.212, with a 95% confidence interval in the range 0.091 to 0.492, P < 0.001) had a protective role against mortality. Conclusion Based on the results of this study, old age, dyspnea, hypertension, ischemic heart disease, dyslipidemia, stroke, malignancy, CRP 3+, and high ESR were identified as predictors of Mortality in Covid-19 patients. Of course, receiving Macrolide and the presence of anorexia had a protective role against mortality in these patients.
A Pairwise Pseudo-Likelihood Approach for Regression Analysis of Left-Truncated Failure Time Data with Various Types of Censoring
Authors: Shao Li , Li Hongxi , Li Shuwei , Sun Jianguo 
Published: November 2022

Abstract
Background: Failure time data occur frequently in many medical studies and often accompany with various types of censoring. In some applications, left truncation may occur and can induce biased sampling, which makes the practical data analysis become more complicated. The existing analysis methods for left-truncated data has some limitations in that they either focus only on a special type of censored data or fail to flexibly utilize the distribution information of the truncation times for inference. Therefore, it is essential to develop an reliable and efficient method for the analysis left-truncated failure time data with various types of censoring. Method: This paper concerns regression analysis of left-truncated failure time data with the proportional hazards model under various types of censoring mechanism, including right censoring, interval censoring and a mixture of them. The proposed pairwise pseudo-likelihood estimation method is essentially built on a combination of the conditional likelihood and the pairwise likelihood that eliminates the nuisance truncation distribution function or avoids its estimation. To implement the presented method, a flexible EM algorithm is developed by utilizing the idea of self-consistent estimating equation. A main feature of the algorithm is that it involves closed-form estimators of the large-dimensional nuisance parameters and is thus computationally stable and reliable. In addition, an R package LTsurv is developed. Results: The numerical results obtained from extensive simulation studies suggest that the proposed pairwise pseudo-likelihood method performs reasonably well in practical situations and is obviously more efficient than the conditional likelihood approach as expected. The analysis results of the MHCPS data with the proposed pairwise pseudo-likelihood method indicate that males have significantly higher risk of losing active life than females. In contrast, the conditional likelihood method recognizes this effect as non-significant, which is because the conditional likelihood method often loses some estimation efficiency compared with the proposed method. Conclusions: The proposed method provides a general and helpful tool to conduct the Cox’s regression analysis of left-truncated failure time data under various types of censoring.