bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ino80 is required for H2A.Z eviction from hypha‐specific promoters and hyphal development of Candida albicans
Authors: Zhao Qun , Dai Baodi , Wu Hongyu , Zhu Wencheng , Chen Jiangye 
Published: June 2022

AbstractATP‐dependent chromatin remodeling complexes play important roles in many essential cellular processes, including transcription regulation, DNA replication, and repair. Evicting H2A.Z, a variant of histone H2A, from the promoter of hypha‐specific genes is required for hyphal formation in Candida albicans. However, the mechanism that regulates H2A.Z removal during hyphal formation remains unknown. In this study, we demonstrated that Ino80, the core catalytic subunit of the INO80 complex, was recruited to hypha‐specific promoters during hyphal induction in Arp8 dependent manner and facilitated the removal of H2A.Z. Deleting INO80 or mutating the ATPase site of Ino80 impairs the expression of hypha‐specific genes (HSGs) and hyphal development. In addition, we showed that Ino80 was essential for the virulence of C. albicans during systemic infections in mice. Interestingly, Arp5, an INO80 complex‐specific component, acts in concert with Ino80 during DNA damage responses but is dispensable for hyphal induction. Our findings clarified that Ino80 was critical for hyphal development, DNA damage response, and pathogenesis in C. albicans.
Early childhood allergy linked with development of attention deficit hyperactivity disorder and autism spectrum disorder
Authors: Nemet Shay , Asher Ilan , Yoles Israel , Baevsky Tuvia , Sthoeger Zev 
Published: June 2022

AbstractBackgroundPrevious studies reported controversial results regarding the association between allergic disorders and attention deficit hyperactivity disorder (ADHD)/autism spectrum disorder (ASD). The aim of this article was to investigate whether allergic disorders are associated with ADHD/ASD in a large cohort of pediatric patients.MethodsA retrospective study using the pediatric (0–18 year) database (ICD‐9‐CM codes) of Clalit Health Services during the years (2000–2018). Diagnosis of all disorders was made by specialist physicians.ResultsA total of 117 022 consecutive non‐selective allergic children diagnosed with one or more allergic disorder (asthma, rhinitis, conjunctivitis, skin, food, or drug allergy) and 116 968 non‐allergic children were enrolled to our study. The mean follow‐up period was 11 ± 6 years. The presence of allergic disorders in early childhood (mean age of allergic diagnosis 4.5 ± 4.3 years) in boys as well as in girls significantly increased the risk to develop ADHD (O.R 2.45, CI 2.39–2.51; p < .0001), ASD (O.R 1.17, CI 1.08–1.27; p < .0001), or both ADHD + ASD (O.R 1.5, CI 1.35–1.79; p < .0001). Children with more than one allergic comorbidity revealed a much higher risk. In a multivariable analysis (adjusted for age at study entry, number of yearly visits, and gender), the risk of allergic children to develop ADHD and ADHD + ASD, but not ASD alone, remained significantly higher.ConclusionAllergic disorder in early childhood significantly increased the risk to develop ADHD, and to a less extend ASD, in later life.
Advancing health equity: Organizational characteristics emphasized by health department nurse lead executives
Authors: Kett Paula M. , Bekemeier Betty , Herting Jerald R. , Altman Molly R. 
Published: June 2022

AbstractObjectiveTo compare nurse and non‐nurse lead executives’ relationship with organizational characteristics supporting performance and health equity in local health departments (LHD).DesignThis was a cross‐sectional quantitative study.SampleThe final national sample consisted of 1447 LHDs using the 2019 Profile of Local Health Departments survey.MeasurementsWe used multivariable logistic and negative binomial regression analyses to explore the relationship between nurse versus non‐nurse LHD lead executives and involvement in ten organizational characteristics including community health assessment (CHA) and community health improvement plan (CHIP) completion and policy activities related to the social determinants of health (SDOH).ResultsMultivariable logistic regression models showed that, for nurse lead executives, the odds of having completed a CHA is 1.49 times, and the odds of having completed a CHIP is 1.56 times, that of non‐nurse lead executives. Negative binomial regression models predicted nurse lead executives, compared to non‐nurses, to perform 1.18 times more SDOH‐related policy activities.ConclusionResults suggest that nurse lead executives are more likely than non‐nurses to emphasize assessment in their work and engage in upstream‐focused policy activities. As such, they are important partners in work to facilitate health equity.
Systematic review of photodynamic therapy for the treatment of hidradenitis suppurativa
Authors: Reshetylo Sofiya , Narla Shanthi , Bakker Caitlin , Freeman Thomas , Farah Ronda S. , Hamzavi Iltefat H. , Goldfarb Noah 
Published: June 2022

AbstractObjectiveTo perform a systematic review of available literature regarding the use of 5‐aminolevulinic acid (ALA) and ALA derivative photodynamic therapy (PDT) in the treatment of hidradenitis suppurativa (HS) and provide recommendations on its use.MethodsA systematic review was performed of all published studies up to September 1, 2019 from nine databases, including PubMed, that evaluated PDT in the treatment of HS. For each study, quality of evidence and risk of bias was evaluated. Recommendations from the body of evidence were created based on Strength of Recommendation and Taxonomy (SORT) criteria.ResultsEighteen studies met inclusion criteria. The majority of studies had a high risk of bias. Blue light PDT with 20% ALA and red light PDT with 16% methyl aminolevulinate (MAL) demonstrated some benefit based on a small number of poor‐quality studies with a high risk of bias (Grade C, level III evidence). The most promising results were for 1%–5% ALA with intralesional diode, with good to complete response in 78%–94% of anatomic sites treated (Grade B, level II evidence).LimitationsThe majority of studies contained high levels of bias, with significant heterogeneity between studies. Conclusions are limited by small samples sizes, lack of randomized controlled trials, and differing protocols.ConclusionFurther studies are needed to determine the clinical efficacy of 20% ALA with blue light and MAL with red light. Intralesional diode PDT shows the most promise and warrants further investigation in larger, randomized controlled trials.
Metabolomic profiling of Dezhou donkey seminal plasma related to freezability
Authors: Wang Zhaofei , Yu Jie , Zhong Shuai , Fan Zhaobin , Wang Fuwen , Ji Chuanliang , Wang Yantao , Lei Chuzhao , Dang Ruihua , Zhao Fuwei 
Published: June 2022

AbstractDonkeys are indispensable livestock in China because they have transport function and medicinal value. With the popularization of artificial insemination on donkeys, semen cryopreservation technology has gradually become a research hotspot. Seminal plasma is a necessary medium for transporting sperm and provides energy and nutrition for sperm. Seminal plasma metabolites play an important role in the process of sperm freezing, and also have an important impact on sperm motility and fertilization rate after freezing and thawing. In this study, liquid chromatography–tandem mass spectrometry (LC–MS/MS) analysis was used to compare the metabolic characteristics of seminal plasma of high freezability (HF) and low freezability (LF) male donkeys. We identified 672 metabolites from donkey seminal plasma, of which 33 metabolites were significantly different between the two groups. Metabolites were identified and categorized according to their major chemical classes, including homogeneous non‐metal compounds, nucleosides, nucleotides, and analogues, organosulphur compounds, phenylpropanoids and polyketide, organoheterocyclic compounds, organic oxygen compounds, benzenoids, organic acids and derivatives, lipids and lipid‐like molecules, organooxygen compounds, alkaloids and derivatives, organic nitrogen compounds. The results showed that the contents of phosphatidylcholine, piceatannol and enkephalin in donkey semen of HF group were significantly higher than those of LF group (p < .05), while the contents of taurocholic and lysophosphatidic acid were significantly lower than those of LF group (p < .05). The different metabolites were mainly related to sperm biological pathway response and oxidative stress. These metabolites may be considered as candidate biomarkers for different fertility in jacks.
Heirs Property, Critical Race Theory, and Reparations☆
Authors: Bailey Conner , Thomson Ryan 
Published: June 2022

AbstractWe use critical race theory (CRT) to examine the involuntary loss of land and homes among Black residents of the southeastern United States and in particular among the Gullah/Geechee. An Afro‐indigenous population, the Gullah/Geechee have deep roots in the federally designated Gullah/Geechee Cultural Heritage Corridor, an area of sea islands and coastal Lowcountry within 25 coastal counties in North and South Carolina, Georgia, and Florida. We identify legal vulnerabilities associated with heirs property, in particular tax sales and predatory partition actions, as mechanisms used within the legal system to dispossess owners of their land. Our use of CRT allows us to understand heirs property as a legacy of the Jim Crow era and to recognize material motivations behind continued racial discrimination that has led to involuntary land loss. CRT also leads us to consider the question of empowerment of the Gullah/Geechee population through a program of reparations for wrongful taking of land and homes since coastal development began roughly 70 years ago. One possible mechanism for reparations is to increase existing lodging taxes on coastal tourism along the Gullah/Geechee coast.
Old‐age poverty in a pension latecomer: The impact of basic pension expansions in South Korea
Authors: Lee Kun 
Published: June 2022

AbstractPension systems and old‐age poverty have been studied mainly from comparative perspectives, but causal evidence on the relationship between the two is still rare. This study investigates to what extent implementing non‐contributory pensions to a latecomer contributory pension system with a wide coverage gap alleviates old‐age poverty, based on the case of recent Basic Pension expansions in South Korea. Using nationally representative household data from 2011 to 2019, we employ a quasi‐experimental difference‐in‐difference design to estimate the impact of policy expansions on a set of outcomes measuring old‐age poverty, employment and household income components. The results show that three reforms in 2014, 2018 and 2019 have significantly reduced older people's poverty rate, and they were more effective in reducing extreme poverty. While policy effects after the 2014 expansion are robust in our set of alternative estimations, those after the joint reforms of 2018 and 2019 are less consistent and show signals of a stronger ‘crowding‐out’ effect on private transfer income than those after 2014. We found no convincing evidence that non‐contributory pensions discourage older people's labour market participation. Our findings contribute to the literature on public pension evaluations by elucidating how non‐contributory pensions affect old‐age poverty and tackle social and economic inequalities via various channels of income components, while also mitigating endogeneity biases observed in previous studies.
Current advances in transfusion medicine 2021: A critical review of selected topics by the AABB Clinical Transfusion Medicine Committee
Authors: Metcalf Ryan A. , Cohn Claudia S. , Allen Elizabeth S. , Bakhtary Sara , Gniadek Thomas , Gupta Gaurav , Harm Sarah , Haspel Richard , Hess Aaron , Jacobson Jessica , Lokhandwala Parvez M. , Murphy Colin , Poston Jacqueline , Prochaska Micah T. , Raval Jay S. , Saifee Nabiha H. , Salazar Eric , Shan Hua , Zantek Nicole D. , Pagano Monica B. 
Published: June 2022

AbstractBackgroundEach year the AABB Clinical Transfusion Medicine Committee (CTMC) procures a synopsis highlighting new, important, and clinically relevant studies in the field of transfusion medicine (TM). This has been made available as a publication in Transfusion since 2018.MethodsCTMC members reviewed and identified original manuscripts covering TM‐related topics published electronically (ahead‐of‐print) or in print from December 2020 to December 2021. Selection of publications was discussed at committee meetings and chosen based on perceived relevance and originality. Next, committee members worked in pairs to create a synopsis of each topic, which was then reviewed by additional committee members. The first and senior authors assembled the final manuscript. Although this synopsis is extensive, it is not exhaustive, and some articles may have been excluded or missed.ResultsThe following topics are included: blood products; convalescent plasma; donor collections and testing; hemoglobinopathies; immunohematology and genomics; hemostasis; patient blood management; pediatrics; therapeutic apheresis; and cell therapy.ConclusionsThis synopsis highlights and summarizes recent key developments in TM and may be useful for educational purposes.
The effects of leukoreduction on canine blood unit weight and processing time
Authors: Trinder Richard D. , Lo Eva , Humm Karen R. 
Published: June 2022

AbstractBackgroundDespite a lack of strong evidence of benefit, leukoreduction is employed to decrease the risk of leukocyte‐induced transfusion reactions. However, the impact of leukoreduction on blood bank costs and inventory management is not well understood. The purpose of this study was to determine whether leukoreduction of whole blood increases total processing time and weight loss from packed red blood cells (PRBCs) and plasma relative to bags created from nonleukoreduced whole blood.Key findingsA total of 68 canine whole blood collections were divided equally into leukoreduced and nonleukoreduced groups (N = 34 in each). There was no significant difference between groups in mean PRBC or plasma unit weights or processing times. Leukoreduced PRBC bags lost a significantly greater proportion of weight during processing than did nonleukoreduced PRBC bags (P < 0.01), which is attributed to red and white blood cells lost in the filtration process.SignificanceLeukoreduction did not lead to a significant increase in processing times or smaller PRBCs or plasma bags compared to nonleukoreduced bags. The blood remaining in the leukoreduction filter following filtration is primarily composed of red blood cells, with minimal plasma retained.
Effect of light intensity on the tear production, central corneal thickness, and intraocular pressure in broiler chickens
Authors: Yaygingul Rahime , Dereli Fidan Evrim , Okur Erdi Ziya , Özturan Yalçın Alper , Akin İbrahim 
Published: June 2022

AbstractObjectiveThe objective of the present study was to examine the effect of different light intensities on tear production, corneal thickness, and intraocular pressure in broilers.Animals studiedBoth eyes of 72 male broilers were evaluated in this study.Materials and MethodsBroilers were divided into the following three groups: low light intensity (n = 24, 5 lux), moderate light intensity (n = 24, 20 lux), and high light intensity (n = 24, 80 lux). The eyes of all birds (n = 72) underwent a complete ophthalmic examination, which included the Schirmer tear test (STT‐I), intraocular pressure (IOP), and the central cornea thickness measurement (CCT). The effect of light intensity on the Schirmer test, intraocular pressure, and central corneal thickness values was examined at eye and animal level (right and left eyes separately and cumulatively/no distinguishing left or right) by using one‐way ANOVA.ResultsAt the animal level, without discrimination of left and right eye measurements, statistically significant differences were found between 5–20 and 20–80 lux groups on IOP measurements (p < .05). The difference in CCT measurements between the 5 and 20 lux groups was statistically significant (p < .05), and the corneal thickness of the 5 lux group animals was found to be statistically significant and higher than the 20 lux group (p < .05).ConclusionsIn conclusion, light intensity has an influence on eye health in broilers. Present results may attribute to the future studies as a reference value for broilers raised under different light intensities.
Novel Modeling of Heat and Moisture Diffusion in Adhesive Joints
Authors: Gerini-Romagnoli Marco , Nassar Sayed A. 
Published: June 2022

Abstract
A novel two-dimensional shear stress-heat and moisture diffusion model is proposed for adhesive single-lap joints. Spatial and time-dependent material properties are derived from coupled partial differential equations governing moisture diffusion and heat transfer through the exposed adhesive edges. Constituting differential equations are numerically solved for the shear stress distribution in the bonded area. Several diffusion scenarios and boundary conditions are analyzed. Significant improvements are achieved in the prediction of the shear stress distribution in the adhesive layer when compared to the one-dimensional models in the literature. Scenarios of moisture diffusion generate stress gradients through the bondline, while the relatively fast internal thermal conductivity reduces temperature differentials within the joint. Moisture diffusion in the adhesive layer is significantly accelerated at high temperatures. The results of the proposed model show reasonable agreement with a three-dimensional finite element analysis.
A Hybrid Algorithm Based on GRNN and Grasshopper Optimization Algorithm for Welding Nugget Diameter Prediction
Authors: Shao Jiayin , Wang Shilong , Yang Bo , Zhang Zhengping , Wang Yankai 
Published: June 2022

Abstract
Resistance spot welding (RSW) is applied extensively by automotive manufacturers for assembling the structural and body components of vehicles. The current method of welding quality inspection is off-line inspection after welding, which cannot provide real-time feedback on welding quality and cannot meet the rhythm of modern production. Therefore, the online non-destructive testing technology of welding quality is worth studying. In this study, an RSW quality prediction model is developed using the improved grasshopper optimization algorithm combined with the generalized regression neural network (GRNN) algorithm, in which the actual process parameters including welding current, welding voltage, energy, power, and pulse width are used as inputs to predict the nugget diameter. During the network training process, the optimization algorithm is used for finding the optimum smoothing factor σ of GRNN, chaotic mapping, and non-uniform mutation are added to the traditional grasshopper optimization algorithm to enhance the optimization ability of the algorithm. Through bootstrap sampling, a comparison experiment about the prediction effect of the proposed quality prediction model with earlier methods is carried out, and the analysis of the experimental results leads to a conclusion that the accuracy of the proposed welding quality prediction model is higher.
Intraoperative indocyanine green fluorescence navigation in a robot-assisted partial nephrectomy for a large renal cell carcinoma in a horseshoe kidney
Authors: Holmes Angela , Tissot Sophie , O'Neill Sarah , Kearns Paul 
Published: June 2022

A man in his 60s was referred to the urology department with an incidental finding of large 75 mm mass within a horseshoe kidney. CT imaging highlighted the well-known aberrant arterial anatomy seen in horseshoe kidney which often causes significant surgical challenges.After careful preoperative planning, the mass was resected successfully during a robot-assisted partial nephrectomy. Intraoperatively, indocyanine green fluorescence navigation helped to confirm arteries supplying area of resection were appropriately clamped, allowing for safe resection of the mass. Histology revealed a chromophobe renal cell carcinoma with clear margins. The patient was discharged on day 4 postoperatively and continues to be cancer free on routine surveillance imaging.
Perianal basal cell carcinoma managed with wide excision and random flap reconstruction
Authors: Lim Michael Geoffrey Lee , Lopez Marc Paul Jose , Yu Jaime Antonio Ong , Albaño Jose Paolo Pantua 
Published: June 2022

Basal cell carcinoma (BCC) is a common skin malignancy and usually occurs in sun-exposed areas like the head and neck. Occurrence in the perianal area is rare, accounting for only 0.08% of all BCC, and 0.2% of anorectal malignancies.We present a case of a hypertensive woman in her 60s who had a 1-year history of a gradually enlarging mass on the left perianal region. Initial biopsy revealed a carcinoma with basaloid features and was confirmed on immunohistochemistry to be nodular BCC. Proctoscopy showed no intraluminal involvement. Contrast-enhanced chest and abdominal CT scans revealed no nodal or distant metastasis. MRI showed a 7.5 mm fat plane between the mass and the external sphincter muscles, projecting adequate surgical margins.A wide excision with at least 4 mm margins was performed. Reconstruction of the resulting defect was performed with a local random cutaneous flap.
Effectiveness of exercise via telehealth for chronic disease: a systematic review and meta-analysis of exercise interventions delivered via videoconferencing
Authors: Brown Riley CC , Coombes Jeff S , Jungbluth Rodriguez Klaus , Hickman Ingrid J , Keating Shelley E 
Published: June 2022

ObjectiveTo investigate the effectiveness of videoconferencing exercise interventions for people with chronic diseases.DesignSystematic review incorporating meta-analysis.Data sourcesPubMed, Cinahl, MEDLINE, Web of Science, Embase and Scopus.Eligibility criteriaThe current literature was searched following Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines. Trials analysing participants with chronic disease undergoing aerobic and/or resistance exercise training over videoconferencing, with exercise capacity and/or quality of life outcomes were included. Meta-analyses were conducted for between-group comparisons of exercise capacity and quality of life. Risk of bias was analysed using the Downs and Black quality checklist and the certainty of evidence with Grading of Recommendations, Assessment, Development and Evaluation (GRADE).ResultsThirty-two trials were included in this review, of which 12 were comparator trials. Small–moderate between-group (videoconferencing vs comparator) effects favouring videoconferencing were seen for studies using a non-exercising comparator for exercise capacity (standardised mean difference (SMD)=0.616, 95% CI 0.278 to 0.954; p=<0.001) and quality of life (SMD=0.400, 95% CI 0.099 to 0.701; p=0.009). Small effects favouring videoconferencing were observed for studies using an exercising comparator for quality of life (SMD=0.271, 95% CI 0.028 to 0.515; p=0.029) and exercise capacity (SMD=0.242, 95% CI 0.059 to 0.426; p=0.009). Moderate risk of bias was identified for included studies (16.3±3.6/28), with GRADE certainty ratings of ‘low’ (quality of life) and ‘moderate’ (exercise capacity). Session attendance was 70% and was reported in 23 trials. No serious adverse events relating to videoconferencing were found. Nine trials documented the total number of technical issues that occurred in 17% of the sessions. Positive satisfaction outcomes were associated with ease of access and usefulness of technology.ConclusionIn patients with chronic disease, videoconferencing exercise interventions appear to be feasible and effective for improving exercise capacity and quality of life. More robust methodology is needed in future studies to improve the certainty of the evidence.PROSPERO registration numberCRD42020191243.