bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identification of a multipotent lung progenitor for lung regeneration
Authors: Rosen Chava , Shetzen Elias , Milman-Krentsis Irit , Qi Yuan , Orgad Ran , Su Xiaohua , Yadav Raj , Shemesh Michal , Biram Adi , Shulman Ziv , Eventov-Friedman Smadar , Maharjan Mukesh , Wang Jing , Biton Moshe , Reisner Yair 
Published: July 2022

AbstractWe recently showed that intravenous infusion of mouse or human, fetal or adult lung cells following conditioning of recipient mice leads to lung chimerism within alveolar and bronchiolar lineages, in distinct ’patches’ containing both epithelial and endothelial cells. We show here, usingR26R-Confettimice as donors, that these multi-lineage patches are derived from a single lung progenitor. FACS of adult mouse lung cells revealed that the putative patch-forming progenitors co-express the endothelial marker CD31 (PECAM-1) and the epithelial marker CD326 (EPCAM). Transplantation of lung cells from transgenic Cre/lox mice expressing nuclear GFP under the VEcad promoter (VEcad-Cre-nTnG), led to GFP+ patches comprising both GFP+ endothelial and epithelial cells in vivo, and in ex-vivo culture of CD326+CD31+ progenitors. Single cell RNA sequencing of CD326+CD31+ lung cells revealed a subpopulation expressing canonical epithelial and endothelial genes. Such double positive GFP+NKX2.1+SOX17+ cells were also detected by immunohistological staining in lungs of VEcad-Cre-nTnG (expressing nuclear GFP) mice in proximity to blood vessels. These findings provide new insights on lung progenitors and lung development and suggest a potential novel approach for lung regeneration.SummaryWe show in the present study, that multi-lineage regenerative patches in our transplantation model are derived from a single lung progenitor, co-expressing the endothelial marker CD31 and the epithelial marker CD326. These findings provide new insights on lung progenitors and lung development.
Impact and mitigation of sampling bias to determine viral spread: evaluating discrete phylogeography through CTMC modeling and structured coalescent model approximations
Authors: Layan Maylis , Müller Nicola F. , Dellicour Simon , De Maio Nicola , Bourhy Hervé , Cauchemez Simon , Baele Guy 
Published: July 2022

AbstractBayesian phylogeographic inference is a powerful tool in molecular epidemiological studies that enables reconstructing the origin and subsequent geographic spread of pathogens. Such inference is, however, potentially affected by geographic sampling bias. Here, we investigated the impact of sampling bias on the spatiotemporal reconstruction of viral epidemics using Bayesian discrete phylogeographic models and explored different operational strategies to mitigate this impact. We considered the continuous-time Markov chain (CTMC) model and two structured coalescent approximations (BASTA and MASCOT). For each approach, we compared the estimated and simulated spatiotemporal histories in biased and unbiased conditions based on simulated epidemics of rabies virus (RABV) in dogs in Morocco. While the reconstructed spatiotemporal histories were impacted by sampling bias for the three approaches, BASTA and MASCOT reconstructions were also biased when employing unbiased samples. Increasing the number of analyzed genomes led to more robust estimates at low sampling bias for CTMC. Alternative sampling strategies that maximize the spatiotemporal coverage greatly improved the inference at intermediate sampling bias for CTMC, and to a lesser extent, for BASTA and MASCOT. In contrast, allowing for time-varying population sizes in MASCOT resulted in robust inference. We further applied these approaches to two empirical datasets: a RABV dataset from the Philippines and a SARS-CoV-2 dataset describing its early spread across the world. In conclusion, sampling biases are ubiquitous in phylogeographic analyses but may be accommodated by increasing sample size, balancing spatial and temporal composition in the samples, and informing structured coalescent models with reliable case count data.
The economic impact of corporate social responsibility on the development of indigenous communities: evidence from Ghana’s mining sector
Authors: Shubita Moade , Ahmed Sabbir , Essel-Paintsil Michael 
Published: July 2022

Purpose
This study aims to examine the socio-economic and environmental impacts of mining activities as perceived by communities in Ghana, with data being drawn from primary and secondary sources.

Design/methodology/approach
A total of 90 community residents were interviewed, with 15 from each of the six selected different communities.

Findings
The findings revealed a positive perception that corporate social responsibility (CSR) practices of mining companies contribute to the development of mining communities in Ghana by creating jobs and generating income. However, it became clear that mining activities, particularly small-scale mining, create many social and environmental challenges as well. This includes land degradation, which reduces the fertility of community-owned land suitable for agricultural use. In addition, pollution of waterways and streams intensifies the plight of community residents living in mining areas.

Originality/value
Since 2011, the mining industry has invested between US$12m (in 2013) and US$44m (in 2011) in Ghana’s communities. The amount spent in 2019 was US$24m. The funds were spent by the industry in areas such as roads, education, health and electricity, among others. Still, it seems more effort is needed by the mining companies to harmonise the CSR practice and gain better impression by local people. In spite of the mining industry’s investment levels, more than half of the community respondents said it was insufficient. One-third of the respondents went as far as suggesting the mining companies had a negative impact on infrastructure improvement and community development.
The impact of coercive pressure and ethical responsibility on cross-functional green management and firm performance
Authors: Yue Xiaochen , Huo Baofeng , Ye Yuxiao 
Published: July 2022

PurposeThe purpose of this paper is to understand whether firms are driven by external pressure or intrinsic value to conduct green management; this study examines the effects of coercive pressure and ethical responsibility on cross-functional green strategy alignment (GSA) and green process coordination (GPC), and in turn, market and environmental performance.Design/methodology/approachBased on data from 206 Chinese manufacturers, this study empirically tests the proposed relationships using structural equation modeling.FindingsThe results highlight the role of coercive pressure in promoting both GSA and GPC that represent functional green efforts at both strategic and operational levels, indicating firms’ critical concern of obtaining external legitimacy from stakeholders. Ethical responsibility as an intrinsic value promotes GPC that demands joint working from different functions at the operational level. Besides, the authors find that GSA improves market and environmental performance, whereas GPC only enhances environmental performance.Originality/valueThis study adds to the knowledge of the drivers of cross-functional green management from external pressure and intrinsic value perspectives. The findings are also fruitful for practitioners and policymakers.
Consumer perspectives on cultural appropriation in fashion: the headdress ban at the Osheaga Music and Arts Festival
Authors: Peters Cara , Lawson Brooks Stephanie 
Published: July 2022

PurposeThis paper examines the discourse of consumers as they attempt to define and create consensus on the meaning and significance of cultural appropriation within a fashion context.Design/methodology/approachData were collected via consumer comments posted to an article fromThe Guardianabout the banning of headdresses from a large-scale music festival in Canada. Data were analyzed according to protocols for grounded theory.FindingsFour themes emerged from the data: values consensus, ideological control, social and symbolic boundaries and social impact and change. These themes captured consumers' perspectives on the debate of cultural appropriation in fashion.Social ImplicationsCultural appropriation has become an increasingly important topic of interest as consumers share their voices online and demand companies increase their cultural competence.Originality/valueFew researchers have examined cultural appropriation in fashion and captured the various perspectives of consumers on this phenomenon.
Multimodal critical-scenarios search method for test of autonomous vehicles
Authors: Feng Tianyue , Liu Lihao , Xing Xingyu , Chen Junyi 
Published: July 2022

Purpose
The purpose of this paper is to search for the critical-scenarios of autonomous vehicles (AVs) quickly and comprehensively, which is essential for verification and validation (V&V).

Design/methodology/approach
The author adopted the index F1 to quantitative critical-scenarios' coverage of the search space and proposed the improved particle swarm optimization (IPSO) to enhance exploration ability for higher coverage. Compared with the particle swarm optimization (PSO), there were three improvements. In the initial phase, the Latin hypercube sampling method was introduced for a uniform distribution of particles. In the iteration phase, the neighborhood operator was adapted to explore more modals with the particles divided into groups. In the convergence phase, the convergence judgment and restart strategy were used to explore the search space by avoiding local convergence. Compared with the Monte Carlo method (MC) and PSO, experiments on the artificial function and critical-scenarios search were carried out to verify the efficiency and the application effect of the method.

Findings
Results show that IPSO can search for multimodal critical-scenarios comprehensively, with a stricter threshold and fewer samples in the experiment on critical-scenario search, the coverage of IPSO is 14% higher than PSO and 40% higher than MC.

Originality/value
The critical-scenarios' coverage of the search space is firstly quantified by the index F1, and the proposed method has higher search efficiency and coverage for the critical-scenarios search of AVs, which shows application potential for V&V.
Social media user-generated content, online search traffic and offline car sales
Authors: Wang Shutian , Lin Yan , Yan Yejin , Zhu Guoqing 
Published: July 2022

PurposeThis study explores the direct relationship between social media user-generated content (UGC), online search traffic and offline light vehicle sales of different models.Design/methodology/approachThe long-run equilibrium relationship and short-run dynamic effects between the valence and volume of UGC, online search traffic and offline car sales are analyzed by applying the autoregressive distribution lag (ARDL) model.FindingsThe study found the following. (1) In the long-run relationship, the valence of online reviews on social media platforms is significantly negatively correlated with the sales of all models. However, in the short-run, the valence of online reviews has a significant positive correlation with all models in different lag periods. (2) The volume of online reviews is significantly positively correlated with the sales of all models in the long run. However, in the short run, the relationship between the volume of online reviews and the sales of lower-sales-volume cars is uncertain. There is a significant positive correlation between the volume of reviews and the sales of higher-sales-volume cars. (3) Online search traffic has a significantly negative correlation with the sales of all models in the long run. However, in the short run, there is no consistent conclusion on the relationship between online search traffic and car sales.Originality/valueThis study provides a reference for managers to use in their efforts to improve offline high-involvement product sales using online information.
Customer brand co-creation on social media: a systematic review
Authors: Le Quynh Hoa , Phan Tan Luc , Hoang Thu Hang 
Published: July 2022

PurposeThis study aims to map existing literature on customer brand co-creation (CBC) in the context of social media and highlight multiple avenues for future research.Design/methodology/approachA systematic literature review (SLR) was used to identify relevant articles in Scopus and ISI Web of Science (WoS) databases to get access to the articles. The final sample of 59 articles on CBC on social media published from 2009 to 2021 was selected for review.FindingsThe findings clarified the conceptualization of CBC and revealed three groups of theories, seven groups of antecedents and two groups of consequences. Then, these components were synthesized into an integrative framework as a basis for further developing this research area.Originality/valueThe findings contribute to the implementation of branding strategies aimed at involving customers in co-creating value for the brand.
Nutritional inter‐dependencies and a carbazole‐dioxygenase are key elements of a bacterial consortium relying on a Sphingomonas for the degradation of the fungicide thiabendazole
Authors: Vasileiadis Sotirios , Perruchon Chiara , Scheer Benjamin , Adrian Lorenz , Steinbach Nicole , Trevisan Marco , Plaza‐Bolaños Patricia , Agüera Ana , Chatzinotas Antonis , Karpouzas Dimitrios G. 
Published: July 2022

AbstractThiabendazole (TBZ), is a persistent fungicide/anthelminthic and a serious environmental threat. We previously enriched a TBZ‐degrading bacterial consortium and provided first evidence for a Sphingomonas involvement in TBZ transformation. Here, using a multi‐omic approach combined with DNA‐stable isotope probing (SIP) we verified the key degrading role of Sphingomonas and identify potential microbial interactions governing consortium functioning. SIP and amplicon sequencing analysis of the heavy and light DNA fraction of cultures grown on 13C‐labelled versus 12C‐TBZ showed that 66% of the 13C‐labelled TBZ was assimilated by Sphingomonas. Metagenomic analysis retrieved 18 metagenome‐assembled genomes with the dominant belonging to Sphingomonas, Sinobacteriaceae, Bradyrhizobium, Filimonas and Hydrogenophaga. Meta‐transcriptomics/‐proteomics and non‐target mass spectrometry suggested TBZ transformation by Sphingomonas via initial cleavage by a carbazole dioxygenase (car) to thiazole‐4‐carboxamidine (terminal compound) and catechol or a cleaved benzyl ring derivative, further transformed through an ortho‐cleavage (cat) pathway. Microbial co‐occurrence and gene expression networks suggested strong interactions between Sphingomonas and a Hydrogenophaga. The latter activated its cobalamin biosynthetic pathway and Sphingomonas its cobalamin salvage pathway to satisfy its B12 auxotrophy. Our findings indicate microbial interactions aligning with the ‘black queen hypothesis’ where Sphingomonas (detoxifier, B12 recipient) and Hydrogenophaga (B12 producer, enjoying detoxification) act as both helpers and beneficiaries.
The Achilles heel of the U.S. food industries: Exposure to labor and upstream industries in the supply chain
Authors: Wahdat Ahmad Zia , Lusk Jayson L. 
Published: July 2022

AbstractThe modern‐day food industries are part of a complex agri‐food supply chain, where food production has become efficient yet potentially vulnerable to supply chain risks. The COVID‐19 pandemic is a testament to that end. This article measures and identifies the U.S. food manufacturing industries' vulnerability to upstream industries and labor occupations by (a) calculating a food industry's diversification of intermediate input purchases across upstream industries, (b) quantifying the relative exposure of food manufacturing in a given industry and location to upstream input suppliers and labor occupations, and (c) estimating each food industry's gross output elasticity of inputs. This article also explores geographic heterogeneity in food industries' vulnerability. Among our results, we find evidence that the animal processing industry's output is relatively vulnerable to production labor, consistent with the observed disruptions to the meatpacking sector during COVID‐19, which were largely caused by labor issues. Our results may help academics and practitioners to understand food industries' vulnerabilities to upstream industries and labor occupations.
Demographic and clinical profile of residents living with dementia and depressive symptoms in Australian private residential aged care: Data from the Music Interventions for Dementia and Depression in ELderly care (MIDDEL) cluster‐randomised controlled trial
Authors: Lee Young‐Eun C. , Sousa Tanara Vieira , Stretton‐Smith Phoebe A. , Gold Christian , Geretsegger Monika , Baker Felicity A. 
Published: July 2022

AbstractObjectives1) To describe the demographic and clinical characteristics of residents with dementia and depressive symptoms in the Australian private residential aged care (RAC) context; and 2) to investigate the association between neuropsychiatric symptoms, depression and quality of life and their interactions with dementia severity.MethodsThis study examined the baseline demographic and clinical data from the Australian arm of the Music Interventions for Dementia and Depression in ELderly care (MIDDEL) study, a multinational, cluster‐randomised controlled trial. Demographic characteristics, neuropsychiatric symptoms, depression, quality of life and dementia severity were collected in 330 residents of 12 private RAC facilities across Melbourne, Australia. Descriptive statistics, the Kruskal–Wallis test and the Pearson Χ2 test were used to describe and compare the demographic and clinical characteristics according to dementia severity. The association between clinical characteristics and dementia severity was examined using linear regression analyses.ResultsResidents' mean age was 86.5 years, 69% were female, and 44.2% had severe dementia. There were no significant differences between the dementia severity groups on age, sex and education. Residents with severe dementia were more likely to have a diagnosis of Alzheimer's disease (40.3%) and be born overseas (46.8%). Higher levels of neuropsychiatric symptoms, distress and depressive symptoms, and lower quality of life were associated with more severe dementia.ConclusionsThe findings from our study highlight the diverse and complex care needs of people living with dementia in the Australian private RAC setting, which can be used to inform targeted, person‐centred dementia care planning, staff training and allocation of resources.
Correlation of 18‐fluorodeoxyglucose uptake values on PET–CT scan with histological prognostic markers in breast cancer
Authors: Muduly Dillip Kumar , Ephraim Rebba , Sultania Mahesh , Ray Sudatta , Bhoriwal Sandeep , Pathak Mona , Kar Madhabananda 
Published: July 2022

AbstractBackgroundPositron emission
tomography–computed tomography (PET‐CT) scan utilizes 18‐fluorodeoxyglucose (18‐FDG), based on the principle of higher glycolytic activity and reduced glucose‐6‐phosphatase levels in cancer cells. This imaging modality is usually advised in the metastatic evaluation of stage III breast cancer patients. The correlation of maximum standard uptake values of primary lesion with different pathological and molecular markers has not been studied extensively.MethodsRetrospective analysis of the data was performed from our prospectively maintained breast cancer database. All the patients who had undergone 18‐FDG PET–CT scan at initial evaluation for staging between June 2017 and April 2020 were included in the study. One‐way ANOVA test or Student's t‐test as appropriate was performed to assess the difference of means in maximum standard uptake values (SUVmax) of the primary lesion and axillary nodes with clinical stage, histological grade, molecular subtype. Bonferroni post hoc test was also applied.ResultsOut of 388 patients in the breast cancer database, 45 patients met inclusion criteria. There was a significant correlation of molecular subtype (p = 0.029) with SUVmax of the primary lesion. Higher primary SUVmax was associated with higher T stage (p = 0.01) and higher histological grade (p = 0.06). In each molecular subtype, there was an increase in mean SUVmax of the primary lesion with increasing histological grade and vice versa.ConclusionsSUVmax of the primary lesion in breast cancer patients reflects tumor biology. Higher SUVmax can predict patients with triple‐negative breast cancers and higher grades in primary tumors. However, further large‐scale validatory studies are essential.
Early childhood development practices in a remote Aboriginal Community Controlled Health Services setting
Authors: Bromley Jane , Sherrard Stephanie , Atkinson David , Marley Julia V. , Henderson‐Yates Lynette , Griffiths Emma 
Published: July 2022

AbstractObjectiveSupporting Early Childhood Development (ECD) is an Australian national priority. Aboriginal children in Western Australia's Kimberley region have much higher rates of developmental concerns at school entry than non‐Aboriginal children. We aimed to describe ECD practices in the participating service; document follow‐up of identified developmental concerns; and identify barriers and enablers to incorporating ECD practices into clinic activity.DesignMixed‐method design incorporating clinical audit and staff interviews.SettingAn Aboriginal Community Controlled Health Service (ACCHS) in the Kimberley region.ParticipantsA total of 176 children receiving primary health care through the participating ACCHS; interviews with five ACCHS staff members.Main outcome measuresFrequency of developmental enquiry by age and domain; follow‐up of identified developmental concerns; and barriers and enablers to ECD practices.ResultsDevelopmental enquiry was documented for 114 of 176 eligible children (65%), including in 80% of ACCHS child health assessments. Standardised ECD assessments were less common. Staff were aware of the importance of developmental enquiry, however, barriers to increasing ECD practices included a lack of resources and structured staff education, time pressures and a lack of role clarity between the ACCHS and government community health clinic.ConclusionsThis study provides insight into ECD practices in an ACCHS setting, highlighting the potential of primary health care to have an enhanced role in ECD if appropriate systems, training and tools are provided. A lack of role clarity across services, combined with poor communication between services, creates a potential risk for missed opportunities to support ECD.