bluuebunny/crossref_metadata_2025_split huggingface dataset:
Handiski simulator performance under PSO-based washout and control parameters optimization
Authors: Houda Taha , Beji Lotfi , Amouri Ali , Mallem Malik 
Published: June 2022

AbstractThe transfer of advanced technology to the person with a disability who wishes to practice a sporting activity is gaining momentum in the science/engineering world. This paper seeks to approve more comfort and sensations for people with paraplegia on a motion simulation platform during a ski operation. The Motion Cueing Algorithm (MCA) has proven itself for sensation reproduction, which we propose to improve by integrating the physical limits of our 8-DoF mechatronics platform. An extended classical MCA is proposed to respond to the significant lack of restored sensation in the intermediate frequency range. A Particle Swarm Optimization (PSO) is constructed to perform optimal washout filter parameters and control law parameters. Consequently, the reproduced skier trajectory stability is obtained. The results show that the proposed algorithm will overcome the physical limitation problem in the Handiski simulator, improve the realism of movement sensation, and reduce the false cues to enhance dynamic fidelity.
Public Sector Strategies in Curbing Corruption: A Review of the Literature
Authors: Ceschel Federico , Hinna Alessandro , Homberg Fabian 
Published: June 2022

AbstractCorruption is widespread and preventive strategies to reduce corruption need to be adapted within the local context. Considering the United Nations (UN) Convention against corruption as our starting point, the paper presents a literature review based on 118 articles on corruption prevention initiatives in the public sector. The analysis indicates a substantial alignment between the guidelines deriving from the UN Convention, except for a lack of work on the risk-based approach to corruption prevention. Further, the review indicates problems with research designs. Based on the insights generated from the analysis, we develop an agenda for future research.
A New Mark of the Cognitive? Predictive Processing and Extended Cognition
Authors: Kersten Luke 
Published: June 2022

AbstractThere is a longstanding debate between those who think that cognition extends into the external environment (extend cognition) and those who think it is located squarely within the individual (internalism). Recently, a new actor has emerged on the scene, one that looks to play kingmaker. Predictive processing (PP) says that the mind/brain is fundamentally engaged in a process of minimising the difference between what is predicted about the world and how the world actually is, what is known as ‘prediction error minimisation’ (PEM). The goal of this paper is to articulate a novel approach to extended cognition using the resources of PP. After outlining two recent proposals from Constant et al. (2020) and Kirchhoff and Kiverstein (2019), I argue that the case for extended cognition can be further developed by interpreting certain elements of the PP story (namely, PEM) as a “mark of the cognitive”. The suggestion is that when construed at an ‘algorithmic level’ PEM offers a direct route to thinking about extended systems as genuine cognitive systems. On route to articulating the proposal, I lay out the core argument, defend the proposal’s novelty, and point to several of the advantages of the formulation. Finally, I conclude by taking up two challenges raised by Hohwy (2016, 2018) about the prospects of using PEM to argue for extended cognition.
Use of virtual care by infectious disease specialists in Canada: A national survey
Authors: Lam Philip W. , Schwartz Ilan S. , Medford Richard J. 
Published: June 2022

Abstract

Objective:
The aim of this study was to characterize the type and extent of virtual care use among infectious disease specialists in Canada, with a focus on the clinical factors that influence the decision to provide virtual versus in-person care.

Methods:
Infectious disease physicians practicing in Canada were invited to complete a survey regarding their experiences with virtual care. The survey included 14 vignettes depicting new outpatient and post–hospital-discharge referrals. Participants were asked to select which (if any) virtual care modalities they would feel comfortable using and to specify a reason if they did not feel comfortable providing care virtually. Machine learning and natural language processing techniques were used to identify themes.

Results:
In total, 57 infectious disease physicians completed the survey. Respondents reported devoting 36.5% (SD, 18.4%) of their infectious disease practice to outpatient care, with 44.2% (SD, 23.2%) of it being delivered virtually. Respondents were more comfortable providing virtual care to post–hospital-discharge referrals who had been seen by an infectious disease physician compared to new outpatient referrals. When respondents were not comfortable with using any virtual care modality, the following common themes emerged: the need for physical examination, the importance of establishing a therapeutic relationship, the need for additional in-person tests or diagnostics, and patient counselling.

Conclusion:
This study provides a glimpse into the current state of virtual care use in Canada and some of the major themes that affect decision making for virtual versus in-person care.
Contrasting haemoparasite prevalence in larid species with divergent ecological niches and migration patterns
Authors: Włodarczyk Radosław , Bouwhuis Sandra , Bichet Coraline , Podlaszczuk Patrycja , Chyb Amelia , Indykiewicz Piotr , Dulisz Beata , Betleja Jacek , Janiszewski Tomasz , Minias Piotr 
Published: June 2022

AbstractHaemoparasites represent a diverse group of vector-borne parasites that infect a wide range of vertebrate hosts. In birds, haemoparasite infection rates may be associated with various ecological and life history traits, including habitat choice, colony size and migration distance. Here, we molecularly assessed the prevalence of 3 main haemoparasite genera (Plasmodium,HaemoproteusandLeucocytozoon) in 2 bird species with different habitat preferences and migratory behaviour: black-headed gulls (Chroicocephalus ridibundus) and common terns (Sterna hirundo). We found that gulls showed a much higher prevalence and diversity ofPlasmodiumorHaemoproteus(ca. 60% of individuals infected) than terns (zero prevalence). The prevalence ofLeucocytozoonwas low in both species (<3%). The differences in haemoparasite prevalences may be primarily driven by varying vector encounter rate resulting from different habitat preferences, as black-headed gulls mainly use vector-rich vegetated freshwater habitats, whereas common terns often use vector-poor coastal and brackish habitats. Since common terns migrate further than black-headed gulls, our results did not provide support for an association between haemoparasite prevalence and migratory distance. In gulls, we found a negative association between colony size and infection rates, suggestive of an ideal despotic distribution, and phylogenetic analyses of detected haemoparasite lineages provided evidence for higher host specificity inHaemoproteusthanPlasmodium. Our results suggest that the preference for coastal areas and less vegetated habitats in terns may reduce haemoparasite infection rates compared to other larids, regardless of their migratory distance, emphasizing the role of ecological niches in parasite exposure.
Compositionalism, Nestorianism, and the principle of no co-member parts
Authors: Hill Jonathan 
Published: June 2022

AbstractCompositionalists hold that God the Son became human by acquiring all the parts that ordinarily compose a human being (his ‘human nature’). To be orthodox, though, they must deny that Christ's human nature is a person, even though it has all the parts that human persons ordinarily have. One way to do this is by appealing to the principle that no member of a natural kind can have another member of the same kind as a proper part. Since Christ is a person, he cannot have another person as a part, so if his human nature is a part of him, it cannot be a person. This principle is defended on the grounds that it can resolve metaphysical problems involving apparently multiple individuals of the same natural kind that share the same space. I argue that this is a weak strategy. First, it leaves unanswered key questions about how and why the principle applies to the incarnation. Second, counter-examples to the principle exist, suggesting that it is not true. Third, there is a better solution to the kinds of metaphysical paradoxes for which this principle is usually invoked, but this solution cannot be applied to the case of Christ. Consequently, compositionalists should not rely on this principle as a means of avoiding Nestorianism.
Which Active Labor Market Policies Work for Male Refugees? Evidence from Germany
Authors: KASRIN ZEIN , TÜBBICKE STEFAN 
Published: June 2022

AbstractIn this paper, we estimate the causal effects of a set of active labor market programs for male unemployed refugees on welfare who entered Germany between, 2013 and September, 2016. Using rich administrative data, we employ covariate balancing propensity scores combined with inverse probability weighting to estimate effects up to 33 months after the start of treatment. Our results show that relatively short-term training in the form of Schemes by Providers and In-Firm Training, as well as longer-term Further Vocational Training programs have a positive impact on both the employment chances as well as labor market earnings of refugees in the medium run. So-called “One Euro Jobs”, a public employment program, does not yield positive effects on employment or earnings. Sensitivity analyses confirm that our results are unlikely to be driven by unobserved confounding.
MODEL THEORY OF GALOIS ACTIONS OF TORSION ABELIAN GROUPS
Authors: Beyarslan Özlem , Kowalski Piotr 
Published: June 2022

AbstractWe show that the theory of Galois actions of a torsion Abelian group A is companionable if and only if, for each prime p, the p-primary part of A is either finite or it coincides with the Prüfer p-group. We also provide a model-theoretic description of the model companions we obtain.
An Efficient and Stable High‐Resolution Seismic Imaging Method: Point‐Spread Function Deconvolution
Authors: Yang Jidong , Huang Jianping , Zhu Hejun , McMechan George , Li Zhenchun 
Published: June 2022

AbstractBy fitting observed data with predicted seismograms, least‐squares migration (LSM) computes a generalized inverse for a subsurface reflectivity model, which can improve image resolution and reduce artifacts caused by incomplete acquisition. However, the large computational cost of LSM required for simulations and migrations limits its wide applications for large‐scale imaging problems. Using point‐spread function (PSF) deconvolution, we present an efficient and stable high‐resolution imaging method. The PSFs are first computed on a coarse grid using local ray‐based Gaussian beam Born modeling and migration. Then, we interpolate the PSFs onto a fine‐image grid and apply a high‐dimensional Gaussian function to attenuate artifacts far away from the PSF centers. With 2D/3D partition of unity, we decompose the traditional adjoint migration results into local images with the same window size as the PSFs. Then, these local images are deconvolved by the PSFs in the wavenumber domain to reduce the effects of the band‐limited source function and compensate for irregular subsurface illumination. The final assembled image is obtained by applying the inverse of the partitions for the deconvolved local images. Numerical examples for both synthetic and field data demonstrate that the proposed PSF deconvolution can significantly improve image resolution and amplitudes for deep structures, while not being sensitive to velocity errors as the data‐domain LSM.
YAP1 induces invadopodia formation by transcriptionally activating TIAM1 through enhancer in breast cancer
Authors: Shen Jie , Huang Qingwen , Jia Weiyi , Feng Shengjie , Liu Liang , Li Xiaolan , Tao Deding , Xie Daxing 
Published: June 2022

AbstractYes-associated protein 1 (YAP1), a central component of the Hippo pathway, plays an important role in tumor metastasis; however, the underlying mechanism remains to be elucidated. Invadopodia are actin-rich protrusions containing multiple proteases and have been widely reported to promote cell invasiveness by degrading the extracellular matrix. In the present study, we report that YAP1 induces invadopodia formation and promotes tumor metastasis in breast cancer cells. We also identify TIAM1, a guanine nucleotide exchange factor, as a target of the YAP1–TEAD4 complex. Our results demonstrate that YAP1 could promote TEAD4 binding to the enhancer region of TIAM1, which activates TIAM1 expression, subsequently increasing RAC1 activity and inducing invadopodia formation. These findings reveal the functional role of Hippo signaling in the regulation of invadopodia and provide potential molecular targets for preventing tumor metastasis in breast cancer.
Longitudinal effects of time since injury and age at injury on outcomes of people with spinal cord injury in Queensland, Australia
Authors: Kendall Melissa B. , Amsters Delena , Schuurs Sarita , Borg David N. , Pershouse Kiley , Kuipers Pim 
Published: June 2022

AbstractStudy designLongitudinal cohort study.ObjectivesTo investigate the longitudinal effects of time since injury and age at injury on outcomes of quality of life, physical function, secondary conditions and participation, in people with traumatic spinal cord injury (SCI).SettingCommunity resident people with spinal cord injury in Queensland, Australia.MethodsA baseline sample of 270 people with SCI was recruited. Telephone surveys on measures of quality of life (WHOQOL-Bref), secondary conditions (Secondary Conditions Surveillance Instrument, subset), physical functioning (Functional Independence Measure motor subscale) and participation (Community Integration Measure) were conducted each year between 2004 and 2008, and again in 2018. Random-effect within-between models were used to determine the effect of time since injury and age at injury on each outcome variable. Inverse probability-of-censoring weights were used to correct for selection bias.ResultsThere was an effect of time since injury on secondary conditions, with a one-year change associated with 9% higher odds of having worse Secondary Conditions Surveillance Instrument scores (odds ratio = 1.09, 95% confidence interval = 1.02, 1.17;p = 0.006). We did not find any evidence of a time since injury effect on quality of life, physical function, or participation. Similarly, we did not find any evidence of an age at injury effect on any outcome variable.ConclusionsSecondary conditions may increase with longer time since injury among people with SCI, suggesting appropriate formal and informal supports are required to minimise the impact of these emerging health problems as individuals age.
Host genomics of SARS-CoV-2 infection
Authors: Redin Claire , Thorball Christian W. , Fellay Jacques 
Published: June 2022

AbstractSARS-CoV-2 infected a large fraction of humans in the past 2 years. The clinical presentation of acute infection varies greatly between individuals, ranging from asymptomatic or mild to life-threatening COVID-19 pneumonia with multi-organ complications. Demographic and comorbid factors explain part of this variability, yet it became clear early in the pandemic that human genetic variation also plays a role in the stark differences observed amongst SARS-CoV-2 infected individuals. Using tools and approaches successfully developed for human genomic studies in the previous decade, large international collaborations embarked in the exploration of the genetic determinants of multiple outcomes of SARS-CoV-2 infection, with a special emphasis on disease severity. Genome-wide association studies identified multiple common genetic variants associated with COVID-19 pneumonia, most of which in regions encoding genes with known or suspected immune function. However, the downstream, functional work required to understand the precise causal variants at each locus has only begun. The interrogation of rare genetic variants using targeted, exome, or genome sequencing approaches has shown that defects in genes involved in type I interferon response explain some of the most severe cases. By highlighting genes and pathways involved in SARS-CoV-2 pathogenesis and host-virus interactions, human genomic studies not only revealed novel preventive and therapeutic targets, but also paved the way for more individualized disease management.
Different bimodal neuromodulation settings reduce tinnitus symptoms in a large randomized trial
Authors: Conlon Brendan , Hamilton Caroline , Meade Emma , Leong Sook Ling , O Connor Ciara , Langguth Berthold , Vanneste Sven , Hall Deborah A. , Hughes Stephen , Lim Hubert H. 
Published: June 2022

AbstractMore than 10% of the population suffers from tinnitus, which is a phantom auditory condition that is coded within the brain. A new neuromodulation approach to treat tinnitus has emerged that combines sound with electrical stimulation of somatosensory pathways, supported by multiple animal studies demonstrating that bimodal stimulation can elicit extensive neural plasticity within the auditory brain. More recently, in a large-scale clinical trial, bimodal neuromodulation combining sound and tongue stimulation drove significant reductions in tinnitus symptom severity during the first 6 weeks of treatment, followed by diminishing improvements during the second 6 weeks of treatment. The primary objective of the large-scale randomized and double-blinded study presented in this paper was to determine if background wideband noise as used in the previous clinical trial was necessary for bimodal treatment efficacy. An additional objective was to determine if adjusting the parameter settings after 6 weeks of treatment could overcome treatment habituation effects observed in the previous study. The primary endpoint at 6-weeks involved within-arm and between-arm comparisons for two treatment arms with different bimodal neuromodulation settings based on two widely used and validated outcome instruments, Tinnitus Handicap Inventory and Tinnitus Functional Index. Both treatment arms exhibited a statistically significant reduction in tinnitus symptoms during the first 6-weeks, which was further reduced significantly during the second 6-weeks by changing the parameter settings (Cohen’s d effect size for full treatment period per arm and outcome measure ranged from − 0.7 to − 1.4). There were no significant differences between arms, in which tongue stimulation combined with only pure tones and without background wideband noise was sufficient to reduce tinnitus symptoms. These therapeutic effects were sustained up to 12 months after the treatment ended. The study included two additional exploratory arms, including one arm that presented only sound stimuli during the first 6 weeks of treatment and bimodal stimulation in the second 6 weeks of treatment. This arm revealed the criticality of combining tongue stimulation with sound for treatment efficacy. Overall, there were no treatment-related serious adverse events and a high compliance rate (83.8%) with 70.3% of participants indicating benefit. The discovery that adjusting stimulation parameters overcomes previously observed treatment habituation can be used to drive greater therapeutic effects and opens up new opportunities for optimizing stimuli and enhancing clinical outcomes for tinnitus patients with bimodal neuromodulation.
Application of gamma irradiation on morphological, biochemical, and molecular aspects of wheat (Triticum aestivum L.) under different seed moisture contents
Authors: Kiani Davood , Borzouei Azam , Ramezanpour Sanaz , Soltanloo Hasan , Saadati Safoora 
Published: June 2022

AbstractNuclear technology is currently used as a tool in mutation breeding to improve crops by increasing genetic variation. The ionization of gamma rays produces large amounts of free radicals, simulating stressors in the natural environment. To avoid gamma-ray-induced oxidative stress, plants use antioxidant defense systems. Exposure of plants to irradiation can affect the germination, growth, and production of metabolites. Plants' sensitivity to irradiation depends on genetic and environmental factors such as moisture content. For this purpose, the effects of different gamma irradiation doses [0, 100, 200, 300, and 400 Gray (Gy)] and different seed moisture contents (7, 13, and 19%) on traits such as seed germination, seedling growth, molecular and biochemical alterations in antioxidant enzymes were examined in the current study. Based on the results, the highest seed germination percentage was observed in the interaction effect of seed moisture at 13% with an irradiation dose of 400 Gy (98.89%). Seedling survival percent and seedling length decreased with increasing doses of gamma irradiation at different seed moisture contents. Increasing gamma irradiation doses were reduced root and stem fresh and dry weight, and root and stem length. The highest level of catalase enzyme activity and expression was observed at 200 and 300 Gy irradiation doses at different moisture contents. The peroxidase and polyphenol oxidase gene expression were reduced at all contents of gamma irradiation doses and seed moisture compared to the control. It can be concluded that the dose of 200–300 Gy of gamma irradiation reduced plant growth by 30% in terms of fresh and dry weight and length of plants, as well as enhanced the expression of antioxidant enzymes. The results of this study could help plant breeders select an appropriate dose rate in wheat for further research.
Mitigation of jet cross-flow induced vibrations using an innovative biomimetic nozzle design inspired by shark gill geometry
Authors: Gad-el-Hak Ibrahim , Mureithi Njuki 
Published: June 2022

AbstractShark gill slits enable sharks to eject the water after the oxygen has been removed in ram ventilation. The reduced effect of jet flow from the gill slits gives sharks smooth maneuverability. A biomimetic “shark nozzle” is proposed to improve mixing between the jet flow and surrounding fluid. Jet flow systems are an essential component of many industrial applications. The key characteristic of jet flow is the mixing process that occurs between two fluid streams to allow heat and/or mass transfer between them. Many industrial and propulsion devices that use jet flows need rapid mixing for effective and environmentally friendly operation. Fuel-injection systems, chemical reactors, and heating and air conditioning systems are examples of devices where a mixing process takes place. Recently, jet flow plays an important role in design and operation of specialized nuclear pressurized water reactors (PWRs). The loss-of-coolant accident (LOCA) holes and slots machined in the core periphery baffle plates are designed to mitigate the effects of a severe LOCA event. However, in normal operation, the holes are a source of a jet flow that can induced vibrations in the fuel assemblies near the baffle before being mixed with the surrounding fluid. This may cause wear and fretting in fuel rods with their supports. The ultimate solution to prevent the fuel assembly vibrations from LOCA hole jetting in a reactor is enhancing mixing of a jet flow with ambient flow in order to rapidly reduce jet momentum. This work proposes a new shark-inspired nozzle design that exploits the observed high efficiency capacity of shark gill slits. Tests are conducted to evaluate the performance of the new design. The obtained results show that the shark-inspired biomimetic nozzle has a greater effect on the rod bundle vibration, and the critical velocity at which the unstable vibration occurs in the rod bundle is delayed by 20% using the biomimetic nozzle. In addition to delaying instability, a vibration amplitude reduction of 85% was obtained by using the proposed shark-inspired nozzle instead of the circular nozzle.