bluuebunny/crossref_metadata_2025_split huggingface dataset:
Molecular architecture of nucleosome remodeling and deacetylase sub‐complexes by integrative structure determination
Authors: Arvindekar Shreyas , Jackman Matthew J. , Low Jason K. K. , Landsberg Michael J. , Mackay Joel P. , Viswanath Shruthi 
Published: August 2022

AbstractThe nucleosome remodeling and deacetylase (NuRD) complex is a chromatin‐modifying assembly that regulates gene expression and DNA damage repair. Despite its importance, limited structural information describing the complete NuRD complex is available and a detailed understanding of its mechanism is therefore lacking. Drawing on information from SEC‐MALLS, DIA‐MS, XLMS, negative‐stain EM, X‐ray crystallography, NMR spectroscopy, secondary structure predictions, and homology models, we applied Bayesian integrative structure determination to investigate the molecular architecture of three NuRD sub‐complexes: MTA1‐HDAC1‐RBBP4, MTA1N‐HDAC1‐MBD3GATAD2CC, and MTA1‐HDAC1‐RBBP4‐MBD3‐GATAD2A [nucleosome deacetylase (NuDe)]. The integrative structures were corroborated by examining independent crosslinks, cryo‐EM maps, biochemical assays, known cancer‐associated mutations, and structure predictions from AlphaFold. The robustness of the models was assessed by jack‐knifing. Localization of the full‐length MBD3, which connects the deacetylase and chromatin remodeling modules in NuRD, has not previously been possible; our models indicate two different locations for MBD3, suggesting a mechanism by which MBD3 in the presence of GATAD2A asymmetrically bridges the two modules in NuRD. Further, our models uncovered three previously unrecognized subunit interfaces in NuDe: HDAC1C‐MTA1BAH, MTA1BAH‐MBD3MBD, and HDAC160–100‐MBD3MBD. Our approach also allowed us to localize regions of unknown structure, such as HDAC1C and MBD3IDR, thereby resulting in the most complete and robustly cross‐validated structural characterization of these NuRD sub‐complexes so far.
Transforming the evaluation of agrochemicals
Authors: Wolf Douglas C , Bhuller Yadvinder , Cope Rhian , Corvaro Marco , Currie Richard A , Doe John , Doi Adriana , Hilton Gina , Mehta Jyotigna , Saltmiras David , Sewell Fiona , Trainer Maria , Déglin Sandrine E 
Published: August 2022

AbstractThe present agrochemical safety evaluation paradigm is long‐standing and anchored in well‐established testing and evaluation procedures. However, it does not meet the present‐day challenges of rapidly growing populations, food insecurity, and pressures from climate change. To transform the current framework and apply modern evaluation strategies that better support sustainable agriculture, the Health and Environmental Sciences Institute (HESI) assembled a technical committee to reframe the safety evaluation of crop‐protection products. The committee is composed of international experts from regulatory agencies, academia, industry and nongovernmental organizations. Their mission is to establish a framework that supports the development of fit‐for‐purpose agrochemical safety evaluation that is applicable to changing global, as well as local needs and regulatory decisions, and incorporates relevant evolving science. This will be accomplished through the integration of state‐of‐the‐art scientific methods, technologies and data sources, to inform safety and risk decisions, and adapt them to evolving local and global needs. The project team will use a systems‐thinking approach to develop the tools that will implement a problem formulation and exposure driven approach to create sustainable, safe and effective crop protection products, and reduce, replace and refine animal studies with fit‐for‐purpose assays. A new approach necessarily will integrate the most modern tools and latest advances in chemical testing methods to guarantee the robust human and environmental safety and risk assessment of agrochemicals. This article summarizes the challenges associated with the modernization of agrochemical safety evaluation, proposes a potential roadmap, and seeks input and engagement from the broader community to advance this effort. © 2022 Health and Environmental Sciences Institute (HESI). Pest Management Science published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.
Topographic gradients of soil physical, chemical, and mineralogical properties in central Kentucky sinkholes
Authors: McGraw Anne , Ramsey Rebecca C. , Obura Pamela , Matocha Christopher , Shepard Christopher 
Published: August 2022

AbstractAn estimated 20% of the world's land surface is underlain by lithologies favorable for karst formation. Karst features (e.g., sinkholes) and soils coevolve, likely influencing local pedogenesis, soil carbon storage, and hydrologic patterns. While karst is widespread, our understanding of the influence of karst geomorphology on pedogenesis remains limited. To better estimate the impact of karst geomorphology on pedogenesis, we characterized nine pedons as a function of landscape position (i.e., toposequence) in two subsidence sinkholes located in the Inner Bluegrass physiographic region of central Kentucky; we characterized a suite of soil physical, chemical, and mineralogical properties. The Inner Bluegrass is underlain by a phosphatic limestone and is susceptible to karst formation. Expectedly, total carbon was greater in lowland positions relative to upland landscape positions. However, inverse relationships between elevation and clay content, selective iron, aluminum, and silicon extracts contradicted previous toposequence trends. Clay mineralogy differences between toeslope and summit positions suggested sediment transport from summit to toeslope positions. Karst geomorphology may limit pedogenesis and facilitate more rapid material export through karst conduits compared to other lithologies. Given the extent of karst terrains and lithologies susceptible to karst formation, future work is needed to understand the magnitude of the impact of karst on pedogenesis and other earth system processes.
The future of the web? The coordination and early‐stage growth of decentralized platforms
Authors: Hsieh Ying‐Ying , Vergne Jean‐Philippe 
Published: August 2022

AbstractResearch SummaryThis abductive study investigates how management occurs without managerial authority as part of a previously unseen organizational form—the decentralized platform with an independent market value. Our mixed‐methods study of the cryptocurrency industry draws on fuzzy‐set qualitative comparative analyses (QCA) to analyze archival and interview data and offer new theory on how decentralized platforms coordinate activities to grow in an early‐stage, before network effects kick in. We find that, in the absence of a central authority, platforms coordinate activities with three mechanisms, namely decentralized (a) algorithmic coordination, (b) social coordination, and (c) goal coordination. Our QCA treat these mechanisms as explanatory conditions and, using a representative sample of 20 cryptocurrency platforms, reveal which configurations of decentralized coordination mechanisms nurture, or hinder, early‐stage platform growth.Managerial SummaryFirms operate around a managerial hierarchy that distributes tasks, resources, information, and rewards to organizational members who pursue common goals as contract‐bound employees. From 2009, a new organizational form, called the “decentralized platform,” emerged and diffused without relying on hierarchy nor managerial authority—and without having to employ anyone. The most prominent decentralized platform, Bitcoin, has millions of users, thousands of contributors, and a market valuation never achieved before by an organization without a CEO nor shareholders. This study explicates how this unprecedented level of organizational decentralization functions in practice. We foreshadow implications for the digital economy, wherein “Web3” innovations, such as non‐fungible tokens and DAOs, have already shifted the orchestrating role played by platforms in capitalist societies.
Phosphorus‐Based Materials for High‐Performance Alkaline Metal Ion Batteries: Progress and Prospect
Authors: Zeng Linchao , Huang Licong , Zhu Jianhui , Li Peipei , Chu Paul K. , Wang Jiahong , Yu Xue‐Feng 
Published: August 2022

AbstractAlkaline metal‐ion batteries (AIBs) such as lithium‐ion batteries (LIBs), sodium‐ion batteries (NIBs), and potassium‐ion batteries (KIBs) are potential energy storage systems. Currently, although LIBs are widely used in consumer electronics and electric vehicles, the electrochemical performance, safety, and cost of current AIBs are still unable to meet the needs for many future applications, such as large‐scale energy storage, due to the low theoretical capacity of cathode/anode materials, flammability of electrolytes and limited Li resources. It is thus imperative to develop new materials to improve the properties of AIBs. Several promising cathodes, anodes, and electrolytes have been developed and among the new battery materials, phosphorus‐based (P‐based) materials have shown great promise. For example, P and metal phosphide anodes have high theoretical capacity, resource abundance, and environmental friendliness boding well for future high‐energy‐density AIBs. Besides, phosphate cathode materials have the advantages of low cost, high safety, high voltage, and robust stability, and P‐based materials like LiPF6 and lithium phosphorus oxynitride are widely used electrolytes. In this paper, the latest development of P‐based materials in AIBs, challenges, effective solutions, and new directions are discussed.
Metal‐Cyclic Dinucleotide Nanomodulator‐Stimulated STING Signaling for Strengthened Radioimmunotherapy of Large Tumor
Authors: Wang Duo , Nie Tianqi , Huang Cuiqing , Chen Zerong , Ma Xiaocong , Fang Weiming , Huang Yanyu , Luo Liangping , Xiao Zeyu 
Published: August 2022

AbstractCombined treatment of immunotherapy and radiotherapy shows promising therapeutic effects for the regression of a variety of cancers. However, even multi‐modality therapies often fail to antagonize the regression of large tumors due to the extremely immunosuppressive tumor microenvironment (TME). Here, a radioimmunotherapeutic paradigm based on stimulator of interferon genes (STING)‐dependent signaling is applied to preclude large tumor progression by utilizing the metal‐cyclic dinucleotide (CDN) nanoplatform, which integrates STING agonist c‐di‐AMP and immunomodulating microelement manganese (II) within the tannic acid nanostructure (TMA‐NPs). As observed by magnetic resonance imaging, the localized administration of TMA‐NPs effectively relieves hypoxia within TME and causes radical oxygen species overproduction and apoptosis in cancer cells after exposure to X‐ray irradiation. The DNA fragments released from the apoptotic cells after the combined treatment augment the production of endogenous CDNs in cancer cells, hence significantly activating the STING‐mediated pathway for stronger anti‐tumor immunity. The localized therapy of TMA‐NPs + X‐ray not only inhibits the primary large tumor progression but also retards distant tumor growth by promoting dendritic cell maturation and activating cytotoxic immune cells whil suppressing immunosuppressive cells. Therefore, this work represents the combinatorial potency of TMA‐NPs and X‐rays on large tumor regression through strengthened STING‐mediated radioimmunotherapeutics.
Cellulose‐Acetate Coating by Integrating Ester Group with Zinc Salt for Dendrite‐Free Zn Metal Anodes
Authors: Liu Xu , Han Qigang , Ma Qingxin , Wang Yuanhao , Liu Chunguo 
Published: August 2022

AbstractZinc (Zn) metal is considered a potential anode owing to its high theoretical capacity, safety, and low cost. However, the dendrites and corresponding side reactions in aqueous electrolytes hinder their further development in environmentally‐friendly energy storage. Herein, ion‐affiliative cellulose acetate (CA) coating with Zn(CF3SO3)2 is constructed on Zn anode (CAZ@Zn). Owing to the complexation effect between the polar ester group (CO) and Zn salt (Zn2+), the CAZ polymer coating enhances the hydrophilicity of the Zn anode and reduces the interfacial resistance, allowing the rapid Zn2+ diffusion and homogenizing the Zn deposition in an aqueous electrolyte to suppress zinc dendrite formation and growth. Therefore, the symmetric CAZ@Zn//CAZ@Zn battery achieves reversible plating/stripping over 2800 h at 1 mA cm−2 with 1 mAh cm−2, about sevenfold higher than bare Zn. The full cell fabricated with an optimized Zn anode and the NH4V4O10 cathode achieves substantially stable performance, superior to that of bare Zn. This work provides a straightforward, effective, and scalable method to suppress the zinc dendrites and corresponding side reactions for aqueous Zn‐ions batteries.
From Materials to Devices: Graphene toward Practical Applications
Authors: Yang Yi , Wei Yuhong , Guo Zhanfeng , Hou Weiwei , Liu Yingjie , Tian He , Ren Tian‐Ling 
Published: August 2022

AbstractGraphene, as an emerging 2D material, has been playing an important role in flexible electronics since its discovery in 2004. The representative fabrication methods of graphene include mechanical exfoliation, liquid‐phase exfoliation, chemical vapor deposition, redox reaction, etc. Based on its excellent mechanical, electrical, thermo‐acoustical, optical, and other properties, graphene has made a great progress in the development of mechanical sensors, microphone, sound source, electrophysiological detection, solar cells, synaptic transistors, light‐emitting devices, and so on. In different application fields, large‐scale, low‐cost, high‐quality, and excellent performance are important factors that limit the industrialization development of graphene. Therefore, laser scribing technology, roll‐to‐roll technology is used to reduce the cost. High‐quality graphene can be obtained through chemical vapor deposition processes. The performance can be improved through the design of structure of the devices, and the homogeneity and stability of devices can be achieved by mechanized machining means. In total, graphene devices show promising prospect for the practical fields of sports monitoring, health detection, voice recognition, energy, etc. There is a hot issue for industry to create and maintain the market competitiveness of graphene products through increasing its versatility and killer application fields.
Organic‐walled microfossils from the Kistedalen Formation, Norway: acritarch chronostratigraphy of the Baltic Miaolingian and evolutionary trends of placoid acritarchs
Authors: Palacios Teodoro , Högström Anette E. S. , Jensen Sören , Ebbestad Jan Ove R. , Agić Heda , Høyberget Magne , Meinhold Guido , Taylor Wendy L. 
Published: August 2022

AbstractNew acritarch data from the Kistedalen Formation based on two sections with continuous exposure enable us to establish the most detailed Miaolingian acritarch biozonation in Baltica to date. Six interval zones previously established in Gondwana, theEliasum llaniscum,Cristallinium cambriense,Adara alea,Timofeevia lancarae,Cristallinium dubiumandVulcanisphaera turbatazones, are identified, and their correlations within the Acado‐Baltic Province examined. The diagnoses ofRetisphaeridium,Cristallinium,Retisphaeridium dichamerum,Retisphaeridium lechistanium,Cristallinium dubiumandCristallinium cambrienseare emended and the new speciesRetisphaeridium rugulatumsp. nov. andRetisphaeridium minimumsp. nov. are described. The diagnosis ofRetisphaeridium ovillense(Cramer & Díez) Vanguestaine is emended and the species assigned toDictyotidium ovillensecomb. nov. The main evolutionary changes of the placoid acritarchs during the Miaolingian are analysed. Comparison with previous acritarch data from the Kistedalen Formation suggests that different extraction methodologies may result in significant bias in the recovered fossil record.
Trilobites of trinucleid, raphiophorid and cyclopygid associations from the Ordovician (Darriwilian – early Katian) of the west Balkhash region and Betpak‐Dala, Central Kazakhstan
Authors: Ghobadi Pour Mansoureh 
Published: August 2022

AbstractMiddle to Late Ordovician (late Darriwilian –early Katian) trilobites from trinucleid, raphiophorid and cyclopygid biofacies are for the first time documented from the West Balkhash and North Betpak‐Dala regions in south‐central Kazakhstan. Twenty taxa are described; six of them, that is,Miaopopsis sokyrensissp. nov.,Pricyclopyge keralensissp. nov.,Kongqiaoheia sarytumensissp. nov.,Shumardia karasaiensissp. nov.,Triarthrus akkermensissp. nov. andMynaralaspis perforatagen. et sp. nov. are new to science. Six taxa are reported in open nomenclature and two are not identified on a genus level. A new trinucleid Subfamily Nanshanaspinae is designated. Newly discovered faunas show strong links to contemporaneous faunas of Tarim and, to a lesser degree, to those of South China and the Australian sector of Gondwana. Based on results of cluster analysis (Dice similarity), trilobite associations of raphiophorid biofacies from the Chu‐Ili and Stepnyak terranes form a single first‐order cluster with little similarity to the trilobite associations characteristic of the nielid and illenid–cheirurid biofacies from the Stepnyak and Tarbagatai regions. Also, there is no distinct interaction between the pelagicDegamella–Pricyclopygeassociation and other trilobite faunas. The geographical distribution of raphiophorid and trinucleid trilobites described in this paper, including species of generaMalongullia?,Miaopopsis,NanshanaspisandKongqiaoheia, supports Ordovician palaeogeographical reconstructions showing the Kazakh terranes as part of a huge archipelago situated on both sides of the equator in proximity to the west coast of Gondwana and positioned a considerable distance from the Siberia continent and its associated terranes.
Bromoacetic acid causes oxidative stress and uric acid metabolism dysfunction via disturbing mitochondrial function and Nrf2 pathway in chicken kidney
Authors: Wu Yuting , Liu Jiwen , Liu Shuhui , Fan Wentao , Ding Chenchen , Gao Zhangshan , Tang Zhihui , Luo Yan , Shi Xizhi , Tan Lei , Song Suquan 
Published: August 2022

AbstractSince the outbreak of COVID‐19, widespread utilization of disinfectants has led to a tremendous increase in the generation of disinfection byproducts worldwide. Bromoacetic acid (BAA), one of the common disinfection byproducts in the environment, has triggered public concern because of its adverse effects on urinary system in mammals. Nevertheless, the BAA‐induced nephrotoxicity and potential mechanism in birds still remains obscure. According to the detected content in the Taihu Lake Basin, the model of BAA exposure in chicken was established at doses of 0, 3, 300, 3000 μg/L for 4 weeks. Our results indicated that BAA exposure caused kidney swelling and structural disarrangement. BAA led to disorder in renal function (CRE, BUN, UA) and increased apoptosis (Bax, Bcl‐2, caspase3). BAA suppressed the expression of mitochondrial biogenesis genes (PGC‐1α, Nrf1, TFAM) and OXPHOS complex I genes (ND1, ND2, ND3, ND4, ND4L, ND5, ND6). Subsequently, BAA destroyed the expression of Nrf2 antioxidant reaction genes (Nrf2, Keap1, HO‐1, NQO1, GCLM, GCLC). Furthermore, renal oxidative damage led to disorder in uric acid metabolism genes (Mrp2, Mrp4, Bcrp, OAT1, OAT2, OAT3) and exacerbated destruction in renal function. Overall, our study provided insights into the potential mechanism of BAA‐induced nephrotoxicity, which were important for the clinical monitoring and prevention of BAA.
Statistical Statements in Probabilistic Logic Programming
Authors: Azzolini Damiano , Bellodi Elena , Riguzzi Fabrizio 
Published: August 2022

AbstractProbabilistic Logic Programs under the distribution semantics (PLPDS) do not allow statistical probabilistic statements of the form “90% of birds fly”, which were defined “Type 1” statements by Halpern. In this paper, we add this kind of statements to PLPDS and introduce the PASTA (“Probabilistic Answer set programming for STAtistical probabilities”) language. We translate programs in our new formalism into probabilistic answer set programs under the credal semantics. This approach differs from previous proposals, such as the one based on “probabilistic conditionals” as, instead of choosing a single model by making the maximum entropy assumption, we take into consideration all models and we assign probability intervals to queries. In this way we refrain from making assumptions and we obtain a more neutral framework. We also propose an inference algorithm and compare it with an existing solver for probabilistic answer set programs on a number of programs of increasing size, showing that our solution is faster and can deal with larger instances.
Grundlagen
Authors: Röper Johann W. A. 
Published: August 2022

ZusammenfassungDas Ziel dieses Grundlagenkapitels ist es, bereits verfügbare Informationen über Kosten, Innovationen und Gestaltungsansätze in Luftrettungssystemen zusammen zu führen. Somit soll ein grundlegendes Verständnis geschaffen werden, aus dem sich die Methodik zur Modellierung von Kosten und Handlungsempfehlungen entwickeln lassen. Dafür wird das System der deutschen Luftrettung anhand von medizinischen, sozio-politischen und betriebswirtschaftlichen Dimensionen beschrieben und erfasst.
Methodik
Authors: Röper Johann W. A. 
Published: August 2022

ZusammenfassungDie vorhergehenden Recherchen zeigen, dass es keine umfassenden Ansätze der ökonomischen Forschung gibt, in denen die dynamischen und komplexen Kostenvariablen des Luftrettungsbetriebes in ihren funktionalen Zusammenhängen modelliert werden. Damit ergibt sich die Notwendigkeit eines Beitrags zur systematischen Bewertung sowie ökonomischen Analyse der luftgestützten Notfallversorgung. Die Modellierung der Kosten des Luftrettungsbetriebes geschieht anhand der Entwicklung einer Gesamtkostenfunktion und der Berechnung von durchschnittlichen Einsatzkosten.
Fazit
Authors: Röper Johann W. A. 
Published: August 2022

ZusammenfassungZiel dieser Arbeit war die ökonomische Modellierung und Analyse der Kosten der Luftrettung, um einen Erkenntnisgewinn über Möglichkeiten zur Steuerung der dynamischen und komplexen Zusammenhänge von Luftrettungssystemen zu erlangen. Die vorgestellten Ergebnisse bringen objektive Elemente in medizinische, aber auch sozio-politische Diskussionen. Gemeinsam mit dem methodischen Ansatz sind die Ergebnisse geeignet, die Gestaltung von Luftrettungssystemen zu unterstützen.
One-loop diagrams with quadratic propagators from the worldsheet
Authors: Feng Bo , He Song , Zhang Yong , Zhang Yao-Qi 
Published: August 2022

Abstract
It is well known that forward limits of tree-level amplitudes (and those trivalent diagrams they consist of) produce one-loop amplitudes and trivalent diagrams with propagators linear in the loop momentum. They naturally arise from one-loop worldsheet formulae, and an important open problem is how to recombine them into usual one-loop diagrams with quadratic propagators. In this paper, we study a new collection of worldsheet functions: generalized one-loop Parke-Taylor factors with tensor numerators, which are conjectured to serve as a basis for one-loop worldsheet functions with this nice property. We present all-multiplicity, closed-form expressions for combinations of one-loop trivalent diagrams with quadratic propagators and tensor numerators to arbitrary rank (including possible tadpole contributions), produced by any pair of Parke-Taylor factors. We also briefly comment on reducing worldsheet functions onto such a basis, and applications to one-loop amplitudes in physical theories.