bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analisis Penilaian Skor Pengungkapan Islamic Social Reporting (ISR) pada PerusahaanYang Terdaftar di Jakarta Islamic Index (JII)
Authors: Meutia Handayani  , Emilda Kadriani  , Icha Ayuningsih  , Talbani Farlian  
Published: April 2022

Penelitian ini bertujuan untuk menganalisis penilaian skor pengungkapan ISR (Islamic Sosial Reporting) pada perusahaan yang terdaftar di Jakarta Islamic Index (JII). Data yang digunakan adalah laporan tahunan perusahaan yang terdaftar pada JII yang mengungkapkan Islamic social repoertingnya. Pengungkapan Islamic social Rrepoerting diperlukan sebagai bentuk tanggung jawab perusahaan yang kegiatannya tidak bertentangan dengan syariat islam kepada lingkungan social disekitarnya. data yang dilakukan dalam penelitian ini adalah dengan menggunakan metode data sekunder dan di lakukan analisis deskriptif terhadap hasil penelitian. Hasil dari penelitian ini menunjukkan bahwa indeks ISR tertinggi dimiliki oleh PT. Aneka Tambang (Persero) Tbk dan PT. Indofood Sukses Makmur Tbk. Skor ISR terendah dimiliki oleh PT. Ciputra Developmen dan Summarecon Agung Tbk
Pengaruh Latihan Kekuatan Otot Lengan Terhadap Kemampuan Tembakan Hukuman (Free Throw) dalam Bola Basket Putra Club Basket Tunas Rejang Lebong
Authors: Alnova Joese , Syafrial Syafrial , Defliyanto Defliyanto 
Published: April 2022

Penelitian ini bertujuan untuk mengetahui pengaruh Latihan Kekuatan Otot Lengan Terhadap Kemapuan Tembakan Hukuman (Free Throw) Dalam Bola Basket. Penelitian ini menggunakan metode eksperimen, design yang digunakan adalah design one group pretest – posttest Populasi dalam penelitian ini berjumlah 25 orang atlet, pemilihan sampel mengunakan total sampling dimana seluruh populasi diambil sebagai sampel penelitian. Teknik pengumpulan data dalam penelitian ini dengan metode tes secara langsung yaitu menggunakan tes (Free Throw) dalam permainan bola basket. Uji persyarat statistik memenuhi syarat homogen dan data berdistribusi normal berdasarkan hitungan statistik didapat hasil dari data t hitung = 7.027 > t tabel = 2.064 dengan taraf = 0,05. Hasil penelitian ini menunjukkan terdapat pengaruh antara Latihan kekuatan otot lengan terhadap kemampuan Tembakan Hukuman (Free Throw) dalam bola basket pada club Basket Tunas Rejang Lebong, sehingga dapat disimpulkan bahwa latihan kekuatan otot lengan mempengaruhi peningkatan bola yang masuk ke dalam ring basket pada tes (Free Throw) dan dapat dijadikan metode latihan untuk meningkatkan perestasi atlet.
PERBAIKAN KERUSAKAN PERKERASAN JALAN MENGGUNAKAN MANUAL DESAIN PERKERASAN JALAN 2017 (MDP JALAN 2017) (STUDI KASUS : JL. LINTAS PADANG – ALAHAN PANJANG)
Authors: Refi Ahmad , Faramida Suci 
Published: April 2022

Abstrak: Kerusakan pada jalan menyebabkan ketidak nyamanan dan berbahaya dalam berkendara, seperti kerusakan yang terjadi pada Jl. Lintas Padang – Alahan Panjang yang merupakan jalan Kolektor Primer yang menghubungkan Ibu Kota Propinsi ke Kota Kabupaten/Kotamadya. Kerusakan pada jalan dapat menghambat fungsi jalan tersebut sehingga harus segera diatasi dengan melakukan perbaikan pada kerusakan jalan yang terjadi. Tujuan penelitian ini untuk mengetahui jenis kerusakan dan penyebab kerusakan jalan serta cara mengatasinya.Manual Desain Perkerasan Jalan 2017 (MDP Jalan 2017) merupakan metode yang akan digunakan dalam penelitian ini sebagai rujukan utama, selain itu akan digunakan beberapa metode lainnya seperti metode Bina Marga 1990 digunakan sebagai analisa dari kerusakkan jalan, dan pentuan nilai CBR dari test DCP, dan metode Perbaikan Standart Bina Marga 1995 digunakan sebagai perbaikan kerusakan jalan sebelum dilakukan overlay, dan untuk desain overlay digunakan metode Analisa Komponen 1987 dan MDP Jalan 2017.Berdasarkan analisa yang dilakukan didapat total angka kerusakan adalah 17 sehingga nilai Urutan Prioritas (UP = 9 7) dengan program pemeliharaan rutin. Perhitungan nilai CBR adalah 3,625% dan nilai DDT adalah 4,105. Untuk perbaikan jalan sebelum dilakukannya overlay mengacu pada metode Perbaikan Standart Bina Marga 1995. Desain tebal overlay dengan metode Analisa Komponen 1987 didapatkan tebal overlay 10 cm dengan bahan Laston sedangkan hasil dari MDP Jalan 2017 didapat tebal overlay 10 cm dengan bahan AC BC normal atau AC BC modifikasi, sehingga solusi overlay digunakan hasil MDP Jalan 2017. Kata Kunci : Kerusakan jalan, Perbaikan jalan, Overlay, MDP Jalan 2017, Analisa Komponen 1987, Bina Marga 1990, Bina Marga 1995, CBR.
Back-End, CMOS-Compatible Ferroelectric FinFET for Synaptic Weights
Authors: Falcone Donato Francesco , Halter Mattia , Bégon-Lours Laura , Offrein Bert Jan 
Published: April 2022

Building Artificial Neural Network accelerators by implementing the vector-matrix multiplication in the analog domain relies on the development of non-volatile and tunable resistances. In this work, we describe the nanofabrication of a three-dimensional HZO—WOx Fin Ferroelectric Field Effect Transistor (FinFeFET) with back-end-of-line conditions. The metal-oxide channel (WOx) is structured into fins and engineered such that: 1) the current-voltage characteristic is linear (Ohmic conduction) and 2) the carrier density is small enough such that the screening length is comparable to one dimension of the device. The process temperature, including the HZO crystallization, does not exceed 400°C. Resistive switching is demonstrated in FinFeFET devices with fins dimension as small as 10 nm wide and 200 nm long. Devices containing a single fin that are 10 nm wide are characterized: 5 µs long voltage pulses in the range (−5.5 and 5 V) are applied on the gate, resulting in analog and symmetric long term potentiation and depression with linearity coefficients of 1.2 and −2.5.
Genetic Etiology of Neonatal Diabetes Mellitus in Vietnamese Infants and Characteristics of Those With INS Gene Mutations
Authors: Ngoc Can Thi Bich , Dung Vu Chi , De Franco Elisa , Lan Nguyen Ngoc , Thao Bui Phuong , Khanh Nguyen Ngoc , Flanagan Sarah E. , Craig Maria E. , Hoang Nguyen Huy , Dien Tran Minh 
Published: April 2022

BackgroundNeonatal diabetes mellitus (NDM) is a rare (1:90,000 newborns) but potentially devastating metabolic disorder characterized by hyperglycemia combined with low levels of insulin. Dominantly-acting insulin (INS) gene mutations cause permanent NDM through single amino acid changes in the protein sequence leading to protein misfolding, which is retained within the endoplasmic reticulum (ER), causing ER stress and β-cell apoptosis. Over 90 dominantly-acting INS gene mutations have been identified in individuals with permanent NDM.Patients and MethodsThe study included 70 infants diagnosed with NDM in the first year of life between May 2008 and May 2021 at the Vietnam National Children’s Hospital. Sequencing analysis of all the genes known to cause NDM was performed at the Exeter Genomic Laboratory, UK. Clinical characteristics, molecular genetics, and annual data relating to glycemic control (HbA1c) and severe hypoglycemia of those with INS mutations were collected. The main outcomes of interest were HbA1c, daily insulin dose, growth, and cognitive/motor development.ResultsFifty-five of 70 infants (78.5%) with NDM harbored a mutation in a known disease-causing gene and of these, 10 had six different de novo heterozygous INS mutations. Mean gestational age was 38.1 ± 2.5 weeks and mean birth weight was 2.8 ± 0.5 g. They presented with NDM at 20 ± 17 weeks of age; 6/10 had diabetic ketoacidosis with pH 7.13 ± 0.26; plasma glucose level 32.6 ± 14.3 mmol/l and HbA1C 81 ± 15% mmol/mol. After 5.5 ± 4.8 years of insulin treatment, 9/10 have normal development with a developmental quotient of 80-100% and HbA1C 64 ± 7.3 mmol/mol, 9/10 have normal height, weight, and BMI on follow-up.ConclusionsWe report a series of Vietnamese NDM cases with dominant INS mutations. INS mutations are the third commonest cause of permanent NDM. We recommend screening of the INS gene in all children diagnosed with diabetes in the first year of life.
Characterization of Pannexin1, Connexin32, and Connexin43 in Spotted Sea Bass (Lateolabrax maculatus): They Are Important Neuro-Related Immune Response Genes Involved in Inflammation-Induced ATP Release
Authors: Sun Zhaosheng , Xu Chong , Chen Yuxi , Liu Danjie , Wu Ping , Gao Qian 
Published: April 2022

Many immunological diseases can be treated by regulating neurobehavior, in which extracellular ATP is a vital member of endogenous danger-associated molecular pattern signaling molecule that plays a crucial part in innate neuro-related immunity. It is actively released through pannexin (Panx) and connexin (Cx) hemichannels from activated or stressed cells during inflammation, injury, or apoptosis. In addition to participating in ATP release, Panxs and Cxs also have crucial immune functions. In this study, pannexin1, three connexin32 isoforms and connexin43 were identified and characterized in spotted sea bass (Lateolabrax maculatus), which were named LmPanx1, LmCx32.2, LmCx32.3, LmCx32.7, and LmCx43. Their similar topological structures were discovered by sequence analysis: a relatively unconserved C-terminal region and four highly conserved transmembrane (TM) domains, and so on. Each extracellular (ECL) region of Panx1 has two conserved cysteine residues. Unlike Panx1, each ECL region of Cx32 and Cx43 contains three conserved cysteine residues, forming two conserved motifs: CX6CX3C motif in ECL1 and CX4CX5C motif in ECL2. Furthermore, Panx1 and Cx43 share similar genomic organization and synteny with their counterparts in selected vertebrates. Cx32 and CX43 were located in the same locus in fish, but diverged into two loci from amphibian. Moreover, despite varying expression levels, the identified genes were constitutively expressed in all examined tissues. All genes were upregulated by PAMP [lipopolysaccharide and poly(I:C)] stimulation or bacterial infection in vivo and in vitro, but they were downregulated in the brain at 6 or 12 h after stimulation. Especially, the three LmCx32 isoforms and LmCx43 were upregulated by ATP stimulation in primary head kidney leukocytes; however, downregulation of LmCx32.3 and LmCx43 expression were noted at 12 h. Conversely, ATP treatment inhibited the expression of LmPanx1. Importantly, we showed that the spotted sea bass Panx1, Cx43, and Cx32 were localized on the cellular membrane and involved in inflammation-induced ATP release. Taken together, our results demonstrated that Panx1, Cx32, and Cx43 are important neuro-related immune response genes involved in inflammation-induced ATP release.
Comparison of Prognosis Between Microscopically Positive and Negative Surgical Margins for Primary Gastrointestinal Stromal Tumors: A Systematic Review and Meta-Analysis
Authors: Liu Zhen , Zhang Yichunzi , Yin Han , Geng Xiuzhu , Li Sishang , Zhao Jinrong , Zeng Ziyang , Ye Xin , Yu Jianchun , Feng Fan , Kang Weiming 
Published: April 2022

BackgroundThis meta-analysis aimed to determine the prognostic impact of microscopically positive margins (R1) on primary gastrointestinal stromal tumors.MethodsA literature search was performed using PubMed, Embase, Web of Science, and Cochrane Library for studies up to 23 November 2020. The pooled disease-free survival (DFS) and overall survival (OS) between R1 and negative margins (R0) were estimated using a random-effects model.ResultsTwenty studies with 6,465 patients were included. Compared with R0 resection, R1 was associated with poor DFS in patients who did not receive adjuvant Imatinib (HR: 1.62, 95% CI: 1.26–2.09; P = 0.48, I2 = 0%; reference: R0). This negative impact of R1 disappeared with the use of adjuvant Imatinib (HR: 1.23, 95% CI: 0.95–1.60; P = 0.38, I2 = 6%; reference: R0). R1 was related to poor DFS in gastric GISTs (HR: 2.15, 95% CI: 1.15–5.02, I2 = 0%; reference: R0), which was attenuated in the subgroup of adjuvant Imatinib (HR: 2.24, 95% CI: 0.32–15.60; P = 0.84, I2 = 0%; reference: R0). Rectal GIST with R1 margin who even received adjuvant Imatinib still had poor DFS (HR: 3.79, 95% CI: 1.27–11.31; P = 0.54, I2 = 0%; reference: R0). Patients who underwent R1 resection had similar OS compared with those underwent R0 resection regardless of the use of adjuvant Imatinib.ConclusionR1 was associated with poor DFS for primary GISTs, which was attenuated by adjuvant therapy with Imatinib. Similar result was observed in the gastric GISTs subgroup. Rectal GIST patients with R1 resection had poor DFS even when they received adjuvant Imatinib. The R1 margin did not influence the OS of GISTs.
Brain Tumor Infodemiology: Worldwide Online Health-Seeking Behavior Using Google Trends and Wikipedia Pageviews
Authors: Mondia Mark Willy L. , Espiritu Adrian I. , Jamora Roland Dominic G. 
Published: April 2022

BackgroundSearching the internet for information on common neurologic symptoms and diseases has been increasing in recent times. It is postulated that online search volume data could be utilized to gauge public awareness and real-world epidemiological data regarding brain tumors.ObjectivesThe goal of this study was to describe the pattern of online search queries of keywords related to neoplasms of the central nervous system (CNS).MethodsUsing Google Trends, search activity from January 2004 – January 2021 was quantified using relative search volume (RSV). The average RSV for the first 3 years was compared with the final 3 years to account for percent change. Wikipedia article views from July 2007 – January 2021 were generated using Pageviews. Peaks in RSV and page views were then matched for related news.Results“Brain tumor”, “brain cancer”, “glioblastoma”, and “glioma” had the highest search volume. RSV from Google Trends and views of Wikipedia pages reflected comparable data in terms of known prevalence rankings of tumor subtypes. There were no observable trends that could correlate to the rising numbers of brain tumor cases worldwide. However, headlines of personalities being diagnosed with glioblastomas were mostly responsible for temporary increases in public interest.ConclusionsTransient rises in online search volume mirror public awareness of more aggressive CNS neoplasms that have a high burden of disease. Worldwide interest in brain tumors may not necessarily correspond to clinical occurrence, but may signify an unmet gap in providing accurate online information to neuro-oncologic patients.
Mathematical Modeling of Complement Pathway Dynamics for Target Validation and Selection of Drug Modalities for Complement Therapies
Authors: Bansal Loveleena , Nichols Eva-Maria , Howsmon Daniel P. , Neisen Jessica , Bessant Christina M. , Cunningham Fraser , Petit-Frere Sebastien , Ludbrook Steve , Damian Valeriu 
Published: April 2022

Motivation:The complement pathway plays a critical role in innate immune defense against infections. Dysregulation between activation and regulation of the complement pathway is widely known to contribute to several diseases. Nevertheless, very few drugs that target complement proteins have made it to the final regulatory approval because of factors such as high concentrations and dosing requirements for complement proteins and serious side effects from complement inhibition.Methods:A quantitative systems pharmacology (QSP) model of the complement pathway has been developed to evaluate potential drug targets to inhibit complement activation in autoimmune diseases. The model describes complement activationviathe alternative and terminal pathways as well as the dynamics of several regulatory proteins. The QSP model has been used to evaluate the effect of inhibiting complement targets on reducing pathway activation caused by deficiency in factor H and CD59. The model also informed the feasibility of developing small-molecule or large-molecule antibody drugs by predicting the drug dosing and affinity requirements for potential complement targets.Results:Inhibition of several complement proteins was predicted to lead to a significant reduction in complement activation and cell lysis. The complement proteins that are present in very high concentrations or have high turnover rates (C3, factor B, factor D, and C6) were predicted to be challenging to engage with feasible doses of large-molecule antibody compounds (≤20 mg/kg). Alternatively, complement fragments that have a short half-life (C3b, C3bB, and C3bBb) were predicted to be challenging or infeasible to engage with small-molecule compounds because of high drug affinity requirements (&gt;1 nM) for the inhibition of downstream processes. The drug affinity requirements for disease severity reduction were predicted to differ more than one to two orders of magnitude than affinities needed for the conventional 90% target engagement (TE) for several proteins. Thus, the QSP model analyses indicate the importance for accounting for TE requirements for achieving reduction in disease severity endpoints during the lead optimization stage.
Autophagy is Involved in Cardiac Remodeling in Response to Environmental Temperature Change
Authors: Ruperez C. , Blasco-Roset A. , Kular D. , Cairo M. , Ferrer-Curriu G. , Villarroya J. , Zamora M. , Crispi F. , Villarroya F. , Planavila A. 
Published: April 2022

Objectives: To study the reversibility of cold-induced cardiac hypertrophy and the role of autophagy in this process.Background: Chronic exposure to cold is known to cause cardiac hypertrophy independent of blood pressure elevation. The reversibility of this process and the molecular mechanisms involved are unknown.Methods: Studies were performed in two-month-old mice exposed to cold (4°C) for 24 h or 10 days. After exposure, the animals were returned to room temperature (21°C) for 24 h or 1 week.Results: We found that chronic cold exposure significantly increased the heart weight/tibia length (HW/TL) ratio, the mean area of cardiomyocytes, and the expression of hypertrophy markers, but significantly decreased the expression of genes involved in fatty acid oxidation. Echocardiographic measurements confirmed hypertrophy development after chronic cold exposure. One week of deacclimation for cold-exposed mice fully reverted the morphological, functional, and gene expression indicators of cardiac hypertrophy. Experiments involving injection of leupeptin at 1 h before sacrifice (to block autophagic flux) indicated that cardiac autophagy was repressed under cold exposure and re-activated during the first 24 h after mice were returned to room temperature. Pharmacological blockage of autophagy for 1 week using chloroquine in mice subjected to deacclimation from cold significantly inhibited the reversion of cardiac hypertrophy.Conclusion: Our data indicate that mice exposed to cold develop a marked cardiac hypertrophy that is reversed after 1 week of deacclimation. We propose that autophagy is a major mechanism underlying the heart remodeling seen in response to cold exposure and its posterior reversion after deacclimation.
Seasonal Changes of Growth, Immune Parameters and Liver Function in Wild Chinese Sturgeons Under Indoor Conditions: Implication for Artificial Rearing
Authors: Zheng Yueping , Zhang Yong , Xie Zhe , Shin Paul K. S. , Xu Jianan , Fan Houyong , Zhuang Ping , Hu Menghong , Wang Youji 
Published: April 2022

Seasonality has a significant effect on the physiology of fish, especially the effect of water temperature changes. In the present study, the growth, innate immune parameters and liver function indices of two rescued wild adult Chinese sturgeons under captive conditions were monitored for 1 year. The results showed that the total annual weight loss rate of the male was −4.58% and the total weight gain rate of the female was 24.12%, in which the weight of both individuals registered highly significant differences in summer, fall and winter (p &lt; 0.01). The male Chinese sturgeon also exhibited negative specific growth rates (−0.1 to −0.8%) during spring to fall, whereas positive specific growth rates, ranging from 0.03 to 0.11%, were recorded in the female. Seasonality also affected the innate immune parameters of the two Chinese sturgeons, in which leukocytes had been increasing since spring and C-reactive protein (CRP) content was significantly higher (p &lt; 0.05) in summer than fall in both individuals. The CRP level of the male Chinese sturgeon showed a significant increase from fall to winter (p &lt; 0.05), suggesting that it may have contracted infection or inflammation during this study period. With the analysis of serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), transaminase (AST:ALT) ratio, alkaline phosphatase, albumin to globulin ratio and triglycerides, it was found that the liver function of the captive Chinese sturgeons was adversely affected along seasonal changes, with the highest degree of liver impairment in winter. In combining observations from growth performance and changes in innate immune and liver function parameters, the present findings deduced that the male Chinese sturgeon under study was more susceptible to seasonal changes than the female. For better indoor culture of adult Chinese sturgeons, monitoring of hematological parameters to detect early signs of inflammation and liver function abnormality should be conducted with routine veterinary care during prolonged captivity.
Contenido de metales pesados (Cu, Pb, Ni, Cd) en abonos orgánicos y las materias primas para su elaboración
Authors: Dueñas-Rivadeneira Juan Pablo , Intriago Flor Frank Guillermo 
Published: April 2022

La utilización de abonos orgánicos tales como compost y humus obtenidos a partir de materias primas de residuos orgánicos, es una alternativa que cada día es más utilizada en diversos cultivos, ante lo cual es necesario realizar una evaluación del contenido de metales pesados, ya que estos pueden acumularse en el suelo como en los sustratos y pueden alterar el equilibrio biológico afectando a la salud del ser humano, siendo una problemática que compromete la seguridad alimentaria y salud pública. El objetivo del presente estudio fue determinar el contenido de metales pesados cobre, plomo, níquel y cadmio (Cu, Pb, Ni, Cd) presentes en las materias primas (pasto de corte, gallinaza, cáscara de maní y estiércol vacuno) en la producción de abonos orgánicos (compost y humus) en la provincia de Manabí, las muestras fueron recolectadas, secadas y tamizadas, luego en el laboratorio se les realizó una digestión con ácido nítrico (HNO3) y peróxido de hidrógeno (H202)utilizando el método 3050B de USDPA. La cuantificación de los metales pesados se realizó por espectrometría ICP ICAP 7200 bajo la Norma EPA 6010C. Los resultados obtenidos fueron validados estadísticamente y demostraron que el contenido de Cu, Pb, Ni, Cd en cada una de las materias primas y abonos orgánicos estaban dentro de los límites permisibles de acuerdo a lo que se establece en el Manual técnico para el registro y control de fertilizantes, enmiendas de suelo y productos afines de uso agrícola emitido por AGROCALIDAD, en el 2020.
Palabras clave: metaloides; bioacumulación; humus; compost; ICP.
A propos des masques et visages rupestres du Sahara
Authors: Soleilhavoup François 
Published: April 2022

Deux grandes catégories de représentations de l’homme existent dans l’art pré- et protohistorique du Sahara : celles, profanes, de la vie matérielle et celles, sacralisées, de la vie spirituelle.
Selon les époques, les lieux et les ethnocultures, les masques anthropomorphes, zoomorphes ou thériomorphes, traduisent des intentions culturelles, rituelles, mythologiques ou symboliques très diverses, mais ils se rapportent toujours aux concepts de la chasse, de la sexualité et de la transcendance divine.
Les visages rupestres, ceux qui personnalisent l’individu, sont très rares. Ils donnent, semble-t-il, une image sacralisée du pouvoir, peut-être théocratique et de la puissance politique dans les sociétés pastorales et nomades. Exceptionnellement, on rencontre des têtes de personnages (Libye) qu’on peut rattacher à l’Histoire connue. Dans la perspective plus lointaine d’un inventaire raisonné de la figure humaine au Sahara, on propose ici quelques éléments de réflexion sur ses différents types et sur les possibles significations qu ’elle peut revêtir dans les paléocultures sahariennes.