bluuebunny/crossref_metadata_2025_split huggingface dataset:
Архитектура как феномен эволюции универсума. Часть 2
Authors: Ткачёв Валентин 
Published: July 2022

Установление универсальных закономерностей процессов морфогенеза материи во вселенском и земном масштабах обнов­ляет устоявшиеся представления об архитектуре как ортодок­сальном средстве материальной и духовной организации бытия.
Стремительность цивилизационных преобразований на планете заставляет переоценить вклад человека в развитие архитектуры и адаптировать стратегию его отношений к не­зависимым формам преобразования среды.
Особенность архитектуры - её структурные построения, корректируются усилиями человека, представляющего хотя и разумный, но все-же только инструмент Универсума, нередко нарушающий линейные процессы эволюции. Виной всему - антропный принцип, наследовавший древний антропомор­физм и средневековый гилозоизм, утверждавшие человека как венец мироздания, довлевшие на самосознание человека сотни лет и тормозившие развитие цивилизации.
Эта часть статьи посвящена современной интерпретации этого принципа и тех его последствий в теории и практике деятельности человека, которые во многом содейссоответ- ствуют до сих пор алогичным, с точки зрения автора, пред­ставлениям о мире, хотя и это всего лишь гипотеза, предла­гаемая критически настроенным дилетантом.
Продолжение.
Начало см. «Academia. Архитектура и строительство», № 1, 2022 год, с. 12-18.
The Audit Quality Effects of Small Audit Firm Mergers in the United States
Authors: Christensen Brant , Smith Kecia Williams , Wang Dechun , Williams Devin 
Published: July 2022

SUMMARY
Increased audit regulation, coupled with reports of frequent mergers among smaller audit firms, creates a dynamic environment in which to assess changes in the U.S. audit market. We examine the audit quality consequences of audit firm mergers between small audit firms that audit public clients, a topic about which little is known. Using a sample of small audit firms each involved in a single merger during 2004–2016, we find consistent evidence that post-merger audit quality decreases when PCAOB-identified audit deficiencies and audit fees are used as proxies for audit quality. In addition, we find weak evidence of lower post-merger audit quality when examining discretionary accruals, and no conclusive post-merger audit quality effect for the probability of misstatements. Overall, our findings provide evidence regarding the audit quality consequences of some small audit firm mergers in the United States.
Data Availability: Data are available from the public sources cited in the text.
JEL Classifications: M42.
Optimal Timing of Intravenous Acetaminophen Administration for Postoperative Analgesia
Authors: Shinoda Maho , Nishimura Akiko , Sugiyama Erika , Sato Hitoshi , Iijima Takehiko 
Published: July 2022

Objective:
Acetaminophen (APAP) is widely used as an analgesic for postoperative pain relief. However, the pharmacokinetic-pharmacodynamic (PK-PD) properties of intravenous APAP administration remain unclear. We developed a PK-PD model in adult volunteers.

Methods:
APAP (1 g) was intravenously administered to 15 healthy volunteers. The pain equivalent current (PEC) was then measured using the pulse current, corresponding to the quantitative value of pain perception. The PK model was developed using a 2-compartment model, and the PD model was developed using a linear model and an effect compartment model.

Results:
APAP plasma concentration peaked just administration, whereas PEC significantly increased at 90 minutes and lasted through the experimental period (300 minutes). APAP plasma concentrations and PEC were processed for use in the PK-PD model. The developed PK-PD model delineates the analgesic effect profile, which peaked at 188 minutes and lasted until 327 minutes.

Conclusion:
We developed the PK/PD model for APAP administered intravenously. The analgesic effect can be expected ∼90 minutes after administration and to last &gt;5 hours. It is suggested that APAP be administered ∼90 minutes prior to the onset of anticipated postoperative pain.
Ultra-Mini Percutaneous Nephrolithotripsy and Retrograde Intrarenal Surgery in Treatment of Less than 2 cm Kidney Stones: Comparative Efficacy and Safety
Authors: Seregin I. V. , Seregin A. A. , Filimonov E. V. , Shustitskiy N. A. , Morozov A. D. , Sinyakova L. A. , Loran O. B. 
Published: July 2022

Background. Renal stones of ≤ 2cm size occur most commonly, with several treatment options currently available that include remote shockwave lithotripsy, percutaneous nephrolithotripsy (PCNL) and retrograde intrarenal surgery (RIRS). The choice of treatment for ≤ 2 cm kidney stones remains a relevant and hotly debated issue.Aim. A study of the efficacy, safety, advantages and disadvantages of ultra-mini percutaneous nephrolithotripsy (ultra-mini PCNL) and retrograde intrarenal surgery (RIRS) in treatment of ≤ 2 cm kidney stones.Materials and methods. Treatment outcomes in urology patients of the Botkin Hospital were analysed retrospectively for years 2017–2022. The patients were divided between cohorts: cohort 1 consisted of patients who underwent ultra-mini PCNL; cohort 2 included 41 patients with RIRS.Results and discussion. The incidence of complete stone absence on the day after surgery was significantly higher in cohort 1 (39; 92.8 %) vs. 2 (33; 80.4 %). Mean operation time was significantly less in cohort 1 (55 [30–80] min) vs. 2 (78 [30–125] min). Mean hospital stay did not differ significantly between the cohorts: 3 (1–5) vs. 2.8 (2–4) days in cohorts 1 and 2, respectively. Haematuria was statistically more severe in cohort 1 (7 cases; 16.6 %) vs. 2 (4 cases; 9.7 %); mean postoperative haemoglobin decrease was also significantly higher in cohort 1 (11.6) vs. 2 (6.4 g/L).Conclusion. Both ultra-mini PCNL and RIRS are effective, safe and complementary procedures in treatment for ≤2 cm renal stones. Ultra-mini PCNL is more effective over RIRS in terms of single-intervention complete stone removal and shorter operation time, whereas the overall complications rate did not significantly differ between cohorts.
Relative Resistance of Ulmaceae for Host Susceptibility, Feeding Preference, and Suitability for the Adult Japanese Beetle (Coleoptera: Scarabaeidae)
Authors: Miller Fredric , Ware George 
Published: July 2022

AbstractLaboratory feeding and fecundity bioassays, and field defoliation surveys were conducted on 73 Ulmus and eight Zelkova taxa to determine their relative susceptibility, preference, and suitability for the adult Japanese beetle (Popillia japonica Newman). Ulmus alata Michx., U. crassifolia Nutt., U. davidiana Planch., U. elliptica K. Koch, , U. glabra Hudson, U. laevis Pall., U. microcarpa, L.K. Fu, U. multinervis (syn. U. castaneifolia) Hemsl., U. parvifolia Jacq., U. propinqua Koidz., U. prunifolia Cheug and L.K. Fu,, U. rubra Muhlenb., U. suberosa Henry, U. sukaczevii Andr., U. .szechuanica Fang., U. taihangshensis S.Y. Wang, U. thomasii Sarg, U. wilsoniana Schneid., ‘Frontier', ‘Homestead', ‘New Horizon', ‘Pioneer', ‘Patriot', U. ‘Morton' Accolade, and U. ‘Morton' Triumph, and Zelkova serrata (Thunb.) Mak. cultivars ‘Green Valley' and ‘Village Green', and Z. schneideriana Hand.-Mazz were the least susceptible to feeding and/or the least suitable for reproduction. Percent leaf tissue removed was highly correlated with field defoliation ratings, but was not a good predictor of fecundity. Asian and European elm leaves were thicker compared with North American elms, and Asian elm leaves were tougher compared with European and North American elm leaves. Host susceptibility and suitability were not related to leaf thickness or toughness. Adult female beetles laid significantly more eggs when feeding on Asian elm taxa compared with European, Eurasian, and North American elm taxa. Hybridization appears to affect host susceptibility. Results reported here provide new insight for the use of Ulmaceae taxa for future reforestation and tree breeding programs.Species used in this study: Ulmus alata Michx., U. americana L., U. bergmaniana var. lasiophylla Schneid., U. canascens Melville, U. carpinifolia Gled.., U. castaneifolia Hemsl., U. changii Hangchow, U. chenmoui Cheng, U. crassifolia Nutt., U. davidiana Planch., U. elliptica K.Koch., U. foliaceae Gilbert, U. gaussenii Cheng,, U. glabra Hudson, U. glaucescens Franch., U. glaucescens Franch. var. lasiocarpa Rehd., U. japonica Sarg., U. laevis Pall., U. lanceaefolia Roxb., U. lamellosa C. Wang et S.L. Chang et L.K. Fu, U. macrocarpa Hance, U. microcarpa L.K. Fu, U. multinervis (syn.U. castaneifolia) Cheng, U. parvifolia Jacq., U. procera Salisb, U. propinqua Koidz., U. propinqua var. suberosa Henry , U. prunifolia Cheng et L.K. Fu , U. pseudopropinqua Wang et Li, U. pumila L., U. rubra Muehl., U. serotina Sarg., U. suberosa Henry, U. sukaczevii Andr., U. szechuanica Fang, U. taihangshanensis S.Y. Wang , U. thomasii, U. wallichiana Planch., U. wilsoniana Schneid., Zelkova serrata (Thunb.) Mak., Z. carpinifolia (Pall.) K. Koch., Z. schneideriana Hand.-Mazz,. Z. sinica C.K. Schneid, Sassafras albidum (Nutt.) Nees.
Low – Permeability Ecological Concrete Mix, By Means of Employing Several Active Admixtures
Authors: Babor Dănuţ-Traian , Isopescu Dorina-Nicolina , Petrescu Tudor-Cristian , Covatariu Daniel 
Published: July 2022

Abstract
There exists an interest to realize impermeable concrete, which would have many applications in bridges and water transport / storage structures, such as tanks, reservoirs, gutters and pipes. Furthermore, it would be possible to use such a type of concrete in other structures where the water pressure represents an exterior action, such as basement walls, caissons and slab foundations. However, absolutely impermeable concrete is almost impossible to be obtained, hence low – permeability concrete could be the correct technical term. In the current article, several samples of such concrete (containing active admixtures) are detailed and relevant conclusions are drawn.
Issues Regarding the Appropriateness of Using Precast Reinforced Concrete Frame Structures Compared to Monolithic Reinforced Concrete Frame Structures, in Office Buildings and Residential Buildings
Authors: Bogdan Hauşi Sorin 
Published: July 2022

Abstract
Given the current context at national and European level in terms of reducing skilled labour force in constructions, as well as the high level of density and traffic in large cities, there is an increasing emphasis on the possibility of shortening the duration of building the structural frames on site, reducing the number of workers or even reducing the level of noise pollution. Thus, the introduction of precast technologies in the case of office buildings and residential buildings, with multi-storey frame structure, is becoming an increasingly pressing and topical issue.
The purpose of this paper is to enable structural engineers, architects and potential investors to consciously choose the type of optimal structure, taking into account a number of technical and economic aspects.
In this sense, in order to highlight the main advantages and disadvantages of using multi-storey precast reinforced concrete frame structures, a comparative case study will be carried out between a precast frame structure and a monolithic frame structure, respectively.
The Permeability Analysis in Case of Tuff and Limestone Addition in the Concrete Composition
Authors: Babor Dănuţ-Traian , Butnariu Marius George , Isopescu Dorina Nicolina 
Published: July 2022

Abstract
This research aimed to analyze the effects of using tuff and limestone as supplementary pozzolanic materials on the permeability of a classic C12/15 concrete composition. There were designed two types of concrete compositions with different degrees of permeability, namely P8
10 and P12
10 as reference concrete compositions and eight experimental concrete compositions with tuff in 6% and 10% of the cement quantity and with limestone in the same proportions. According to results, the tuff and limestone led to the decrease of concrete permeability, the best values being registered in the case of using 10% tuff in the concrete composition with P8
10 class of permeability.
Corchorus olitorius L. (Jute) leaf and seed extracts exerted high antibacterial activity against food and plant pathogenic bacteria
Authors: İşeri Özlem Darcansoy , Körpe Didem Aksoy , Sahin Feride Iffet , Cabi Evren , Haberal Mehmet 
Published: July 2022

Abstract
Aim of this study was to comparatively evaluate antibacterial activities of methanol (MetOH), acetone (Ace), petroleum ether (PE) and aqueous (dw) leaf (L), root (R), and seed (S) extracts of Corchorus olitorius L. on both food- and plant-borne pathogens, with DPPH radical scavenging activities (DRSA), and quantitative and qualitative constituent analysis. Leaf PE has the highest strain susceptibility on both food- and plant-borne pathogens. Clavibacter michiganensis, Pseudomonas tomato, and Erwinia caratovora were susceptible to nearly all the leaf and seed extracts. Very low minimum inhibitory concentration (8-128 μg mL−1) and minimum bactericidal concentration (32-2048 μg mL−1) were determined for both leaf and seed extracts against C. michiganensis. Total phenolic contents were correlated to DRSA. The phenolic compounds tested were higher in the leaf MetOH, cholorogenic acid being the most abundant one. Palmitic acid was determined in leaf PE and seed PE extracts. Results presented here demonstrate high antibacterial activity of C. olitorius leaf seed extracts against phytopathogens for the first time, and provide the most comprehensive data on the antibacterial activity screening against food-borne pathogens. Considering limitations in plant disease control, antibacterial activities of these extracts would be important in plant disease control.
Development of a database of RNA helicase inhibitors (VHIMDB) of pathogenic viruses and in silico screening for the potential drug molecules
Authors: Satpathy R , Acharya S 
Published: July 2022

AbstractThe pathogenic RNA virus that infects human beings contains the RNA helicase enzyme, responsible for the replication of the viral genome. The enzyme is used as a suitable target against which the drug molecule acts. Therefore, the identification and proposal the novel compounds that can be targeted toward the helicase enzymes to stop the functioning of the enzyme is desirable. Although many viral helicase inhibitor molecules have been identified, still yet no unique database is available for these compounds. This research work envisages developing a curated database of RNA helicase inhibitors. The database contains in total of 353 entries that are computationally predicted and experimentally verified RNA helicase inhibitors. The database contains information like compound name, chemical properties, chemical format, and name of the target virus to which it acts against it with a user-friendly menu-driven search engine. Presently, the database is freely available at:https://vhimdb.rsatpathy.in/. Further, in silico screening of the whole database by drug-likeness and toxicity resulted in 14 potential drug molecules. The selected molecules were analyzed for their effectiveness in binding by using molecular docking score and interaction with the helicase enzymes of three categories of pathogenic viruses (SARS-CoV-2, SARS-CoV, and MERS-CoV).
Impact of tracheostomy in patients with severe acute respiratory syndrome due to coronavirus infection
Authors: Lugo-Machado Juan Antonio , Guerrero-Paz Jose Alberto , Fuentes Nohemí Sainz , Emiliana Patricia , Ramírez García , Valenton Elizabeth Medina 
Published: July 2022

Abstract

OBJECTIVE. To estimate the effect of tracheostomy on ventilation in patients with COVID-19.

MATERIAL AND METHODS. An observational, retrospective, analytical, longitudinal study of a consecutive series of cases was carried out between April 2020 and March 2021. The study included data about different variables, such as age, sex, comorbidities, time of orotracheal intubation, place of surgery, complications and death, ventilatory parameters, blood gas and time of the weaning after tracheostomy. Descriptive statistics were used with measures of central tendency, measures of dispersion and the Wilcoxon test to see differences in the ventilatory parameters.

RESULTS. The study was performed on 130 patients admitted to the ICU with intubation to manage their critical condition. From these patients, the study group included 31 who underwent tracheostomy, 25 males (80.64%) with a mean age of 57.1±13.395 years and with 20.52±6.722 days in orotracheal intubation. Among the most frequent comorbidities, we encountered: arterial hypertension (51.6%), obesity (35.4%), diabetes mellitus (22.5%), hypothyroidism (6.4%), asthma (3.2%), pregnancy (3.2%), chronic obstructive pulmonary disease (3.2%) and obstructive sleep apnea syndrome (3.2%). The main complications were bleeding (12.9%) and decannulation (3.2%). The survival rate was 90.32%. Comparing the pre-surgical and postoperative outcomes of the ventilatory parameters and blood gas, statistically significant differences were found only in case of PEEP (p = 0.033), FiO2 (p = 0.001) and O2 saturation (p = 0.001). The average removal of the ventilator was 4.3±2.437 days.

CONCLUSION. There were no significant changes in the ventilatory parameters, however, they were sufficient to wean the patients from the ventilation team and discharge them to the internal medicine department to continue their management outside the intensive care unit.
Expressions of TGF-β1 and VEGF in patients with acute myeloid leukemia and associations with prognosis
Authors: Xu Yan , Yu Xianqiu , Zhang Xinlong 
Published: July 2022

Abstract

Background: To study the expressions of transforming growth factor-β1 (TGF-β1) and vascular endothelial growth factor (VEGF) in patients with acute myeloid leukemia (AML) and their values for prognosis.

Methods: A total of 120 AML patients treated from January 2015 to December 2018 were selected. Bone marrow mononuclear cells were isolated. The expressions of TGF-β1 and VEGF were detected by RT-PCR, and their associations with clinical characteristics were analyzed. The overall survival (OS) and disease-free survival (DFS) were assessed using the Kaplan-Meier method. The risk factors for prognosis were analyzed through the Cox proportional hazards model.

Results: The AML group had significantly lower relative expression of TGF-β1 and higher relative expression of VEGF than those of the control group (P<0.05). TGF-β1 and VEGF levels were significantly correlated with white blood cell count, hemoglobin, platelets, and peripheral blood juvenile cells (P<0.05). TGF-β1 level was higher and VEGF level was lower in the patients with complete response than those in the patients with partial response and no response (P<0.05). Both OS and DFS of the patients with high TGF-β1 expression were better than those of the patients with low TGF-β1 expression, while they were also superior among the patients with low VEGF expression (P<0.05). Platelets, TGF-β1 and VEGF were independent influencing factors for OS, and white blood cells, TGF-β1 and VEGF were independent influencing factors for DFS (P<0.05).

Conclusions: AML patients have decreased expression of TGF-β1 and increased expression of VEGF, and such changes are closely associated with the prognosis of AML.
Comprehensive assessment of the speech development of children conceived by IVF
Authors: Surkova K. L. , Zvereva N. V. , Sergienko A. A. , Strogova S. E. , Zvereva M. V. 
Published: July 2022

Introduction. The high frequency of the use of assisted reproductive technologies and the inconsistency of information about the parameters of the cognitive development of IVF children determined the formulation of the research problem.The purpose of the work is to assess the originality of the speech development of children and adolescents conceived using the IVF procedure. The age of the children at the time of the survey was from 5 to 15 years.Methods and materials. A sample of 51 children (29 boys), mean age (7.9±2.8) years, 14 children had psychiatric diagnoses (ASD, mental retardation, etc.). Research methods: speech therapy assessment of speech development, neuropsychological diagnostics according to L.S. Tsvetkova, WICS, descriptive statistics, correlation analysis.Results. 41% of children had mild variants of speech development delay under 3 years old, 59 % of children had normal speech development. With age, the frequency of detected deviations in speech development decreases, so that in older age group (from 11 to 15 years old), 85 % have normotypical development of speech. Correlation analysis showed the originality of the correlations of the parameters of speech development, neuropsychological assessment, and scores on Wechsler subtests.Conclusions. An unambiguous conclusion about the violation of speech development in children conceived by IVF cannot be drawn, however, in the presence of mental pathology and taking into account the age of the mother and the number of ART procedures, attention should be paid to the provision of speech therapy and neuropsychological correction from an early age.
Empirical measurement of attitudes to new forms of employment in the era of "coronacen"
Authors: Naberushkina Elmira Kamalovna 
Published: July 2022

The subject of the research of this article is the analysis of the remote form of employment scaled due to the pandemic of 2020-2021. The object of the study was the attitude of working Muscovites to the remote form of work. The use of qualitative and quantitative research methodology made it possible to find out the difficulties and advantages of remote work, to identify changes in the family and professional field that occurred as a result of the transfer of labor functions to a new format. The embedded indicators made it possible to assess the attitude to the new format of work, to identify the changes that have occurred between relatives and colleagues, to assess the prospects for further use of the remote format, to speak out about the acceptability of remote work. The COVID-19 pandemic has led to serious changes in the functioning of public systems, including employment. The Coronacen era triggered changes in the field of professional activity and everyday life of people, pushed states to act faster and promptly regarding the introduction of remote employment, exacerbated the need for social institutions to respond quickly on the entire spectrum of issues related to social guarantees and conditions for the development of new forms of employment. This necessitates a comprehensive study of the ongoing processes and forecasting their consequences. The results presented in this article may be of interest to researchers dealing with the transformation of the labor market and employment, as well as to government specialists who are involved in the implementation of state employment policy.