bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fabric‐Based Wearable Self‐Powered Asymmetric Supercapacitor Comprising Lead‐Free Perovskite Piezoelectrodes
Authors: Padha Bhavya , Verma Sonali , Arya Sandeep 
Published: May 2022

AbstractThe demand for flexible supercapacitor sustaining green energy can go a long way in mitigating the issue of no power source in wearable electronics. Herein, a novel strategy is used to develop a self‐charging supercapacitor using lead‐free perovskites as piezoelectrodes and polyvinyl alcohol‐potassium hydroxide (PVA‐KOH) film as ionogelled electrolyte. This approach is unique as the existing conventional self‐powered devices are based only on piezoelectric electrolytes. The all‐solid‐state supercapacitor is asymmetric, with nickel stannate (NiSnO3) acting as the positrode and ferrous stannate (FeSnO3) as the negatrode. These materials are non‐toxic, environment‐friendly, and bio‐compatible, making them suitable for wearable electronics. The value of specific capacitance of FeSnO3 is 2853 F g–1, the highest among the perovskite‐based electrodes. The self‐charging characteristics of the fabricated supercapacitor are analyzed by bending, twisting, and subjecting it to compressive forces of varying magnitude. A maximum voltage of 266 mV is recorded through the self‐charging phenomenon. All these tests approve that the fabricated perovskite‐based supercapacitor is highly flexible, robust, stable, and has considerable electrochemical and self‐charging potential. The present study focuses on understanding the piezoelectric effect in self‐charging supercapacitors and offering a viable power option for self‐powered wearable devices in the future.
High‐Efficiency Metasurface Emitters for Generating Arbitrarily Polarized Spatial Propagating Waves
Authors: Zhang Tai Yi , Ma Hui Feng , Wang Hai Lin , Zhang Yan Kai , You Zi Hua , Cui Tie Jun 
Published: May 2022

AbstractPolarization plays an important role in practical applications, and hence it is an essential task to generate the desired polarization of a spatial propagating wave (SPW). Here, the authors propose a method to design radiation metasurface, or metasurface emitter, which can produce arbitrarily polarized SPW. Different from the conventional transmission and reflection metasurfaces that can only manipulate the incoming spatial wave, the proposed radiation metasurface can be regarded as an electromagnetic (EM) wave emitter that can generate SPW by itself. More importantly, the polarization of the generated SPW can be flexibly customized by designing the phase distribution on metasurface. The metasurface is fed by a monopole antenna, and the energy is first coupled into the metasurface to form a surface wave. Modulated by the metasurface, the surface wave is then converted into SPW. As a proof of concept, they design and fabricate the radiation metasurfaces that are capable of generating radially, azimuthally, linearly, and circularly polarized SPWs, as well as dual‐beam radiations with different polarizations, respectively. The measured results have a good match to the theoretical predictions and full‐wave simulations. The proposed method provides an efficient way to generate SPWs with any desired polarizations for easy integration.
Statistic Copolymers Working as Growth Factor‐Binding Mimics of Fibronectin
Authors: Zhang Wenjing , Wu Yueming , Chen Qi , Zhang Haodong , Zhou Min , Chen Kang , Cao Chuntao , Guo Han , Xu Jianrong , Liu Honglai , Lin Haodong , Liu Changsheng , Liu Runhui 
Published: May 2022

AbstractGrowth factors (GFs) play important roles in biological system and are widely used in tissue regeneration. However, their application is greatly hindered by short in vivo lifetime of GFs. GFs are bound to fibronectin dynamically in the extracellular matrix, which inspired the authors to mimic the GF binding domain of fibronectin and design GF‐binding amphiphilic copolymers bearing positive charges. The optimal amino acid polymer can bind to a variety of representative GFs, such as bone morphogenetic protein‐2 (BMP‐2) and TGF‐β1 from the transforming growth factor‐β superfamily, PDGF‐AA and PDGF‐BB from the platelet‐derived growth factor family, FGF‐10 and FGF‐21 from the fibroblast growth factor family, epidermal growth factor from the EGF family and hepatocyte growth factor from the plasminogen‐related growth factor family, with binding affinities up to the nanomolar level. 3D scaffolds immobilized with the optimal copolymer enable sustained release of loaded BMP‐2 without burst release and significantly enhances the in vivo function of BMP‐2 for bone formation. This strategy opens new avenues in designing GF‐binding copolymers as synthetic mimics of fibronectin for diverse applications.
Changes in drug poisoning mortality before and after the COVID‐19 pandemic by occupation in Massachusetts
Authors: Hawkins Devan , Phan Anh Tuan 
Published: May 2022

AbstractBackgroundIncidence of drug poisoning deaths has increased during the coronavirus disease 2019 (COVID‐19) pandemic. Previous research has established that risks differ for drug poisoning death according to occupation, and that workers also have a different risk for exposure to and death from COVID‐19. This study sought to determine whether workers in certain occupations had drug poisoning mortality rates that increased in 2020 (the first year of the COVID‐19 pandemic) compared to the average mortality rate for workers in those occupations during the previous 3 years.MethodsDeath certificates of Massachusetts residents who died from drug poisonings in 2017–2020 were obtained. Average mortality rates of drug poisoning according to occupation during the 2017–2019 period were compared to mortality rates in 2020.ResultsBetween the 2017–2019 period and 2020, mortality rates of drug poisoning increased significantly for workers in three occupational groups: food preparation and serving; healthcare support; and transportation and material moving. In these occupations, most of the increases in 2020 compared to 2017–2019 occurred in months after COVID‐19 pandemic cases and deaths increased in Massachusetts.ConclusionMortality rates from drug poisonings increased substantially in several occupations in 2020 compared to previous years. Further research should examine the role of occupational factors in this increase in drug poisoning mortality rates during the COVID‐19 pandemic. Particular attention should be given to determine the role that exposure to severe acute respiratory syndrome coronavirus 2, work stress, and financial stress due to job insecurity played in these increases.
Fluorinating the Solid Electrolyte Interphase by Rational Molecular Design for Practical Lithium‐Metal Batteries
Authors: Xie Jin , Sun Shu‐Yu , Chen Xiang , Hou Li‐Peng , Li Bo‐Quan , Peng Hong‐Jie , Huang Jia‐Qi , Zhang Xue‐Qiang , Zhang Qiang 
Published: May 2022

AbstractThe lifespan of practical lithium (Li)‐metal batteries is severely hindered by the instability of Li‐metal anodes. Fluorinated solid electrolyte interphase (SEI) emerges as a promising strategy to improve the stability of Li‐metal anodes. The rational design of fluorinated molecules is pivotal to construct fluorinated SEI. Herein, design principles of fluorinated molecules are proposed. Fluoroalkyl (−CF2CF2−) is selected as an enriched F reservoir and the defluorination of the C−F bond is driven by leaving groups on β‐sites. An activated fluoroalkyl molecule (AFA), 2,2,3,3‐tetrafluorobutane‐1,4‐diol dinitrate is unprecedentedly proposed to render fast and complete defluorination and generate uniform fluorinated SEI on Li‐metal anodes. In Li–sulfur (Li−S) batteries under practical conditions, the fluorinated SEI constructed by AFA undergoes 183 cycles, which is three times the SEI formed by LiNO3. Furthermore, a Li−S pouch cell of 360 Wh kg−1 delivers 25 cycles with AFA. This work demonstrates rational molecular design principles of fluorinated molecules to construct fluorinated SEI for practical Li‐metal batteries.
Reversible Multilevel Stimuli‐Responsiveness and Multicolor Room‐Temperature Phosphorescence Emission Based on a Single‐Component System
Authors: Song Jinming , Ma Liangwei , Sun Siyu , Tian He , Ma Xiang 
Published: May 2022

AbstractThere are limited reports about the transformation of pure organic room‐temperature phosphorescence (RTP) materials with multilevel stimuli‐responsiveness at different RTP emission wavelengths under external stimuli. It is difficult to ensure efficient intersystem crossing (ISC) in different states of a single‐component system. This research reports the conversion of the organic single‐component small molecule 1,2‐bis(4‐alkoxyphenyl)ethane‐1,2‐dione (N‐BOX) with multilevel stimuli‐responsiveness between high‐efficiency blue and yellow RTP by grinding or thermal annealingN‐BOXcrystals. The RTP emission ofN‐BOXin the crystalline state was easy to adjust by external stimuli (grinding or thermal annealing) due to its non‐compact packing, which led to a phase transition and generated unique multilevel stimuli‐responsiveness. In particular, the RTP quantum yield of7‐BOXwith multilevel stimuli‐responsiveness reached 68.4 %, which provides an opportunity for regulation of smart optical materials based on pure organic RTP.
Chemical Approaches to Synthetic Drug Delivery Systems for Systemic Applications
Authors: Braatz Daniel , Cherri Mariam , Tully Michael , Dimde Mathias , Ma Guoxin , Mohammadifar Ehsan , Reisbeck Felix , Ahmadi Vahid , Schirner Michael , Haag Rainer 
Published: May 2022

AbstractPoor water solubility and low bioavailability of active pharmaceutical ingredients (APIs) are major causes of friction in the pharmaceutical industry and represent a formidable hurdle for pharmaceutical drug development. Drug delivery remains the major challenge for the application of new small‐molecule drugs as well as biopharmaceuticals. The three challenges for synthetic delivery systems are: (i) controlling drug distribution and clearance in the blood; (ii) solubilizing poorly water‐soluble agents, and (iii) selectively targeting specific tissues. Although several polymer‐based systems have addressed the first two demands and have been translated into clinical practice, no targeted synthetic drug delivery system has reached the market. This Review is designed to provide a background on the challenges and requirements for the design and translation of new polymer‐based delivery systems. This report will focus on chemical approaches to drug delivery for systemic applications.
Structure Elucidation of In Situ Generated Chiral Hypervalent Iodine Complexes via Vibrational Circular Dichroism (VCD)
Authors: Golub Tino P. , Abazid Ayham H. , Nachtsheim Boris J. , Merten Christian 
Published: May 2022

AbstractThe structure of in situ generated chiral aryl‐λ3‐iodanes obtained under oxidative reaction conditions was not yet observable with experimental techniques and their proposed structures are purely based on DFT calculations. Herein, we establish vibrational circular dichroism (VCD) spectroscopy as an experimental technique to verify DFT‐calculated chiral iodane structures. Based on a chiral triazole‐substituted iodoarene catalyst, we were able to elucidate a yet undescribed cationic chiral iodane as the most populated intermediate under oxidative conditions with a significant intramolecular N−I‐interaction and no significant interactions with tosylate or m‐chlorobenzoic acid as potential anionic ligands. Instead, aggregation of these substrates was found, which resulted in the formation of a non‐coordinating anionic hydrogen bonded complex. The importance of VCD as a crucial experimental observable is further highlighted by the fact that our initial structural proposal, that was purely based on DFT calculations, could be falsified.
The infantile and the need for narratives as essential myths
Authors: Poppensieker Klaus 
Published: May 2022

AbstractNarratives and essential myths carry a fundamental holding function. Human beings need their beliefs to experience a sense of coherence and security. In this essay, I argue that individuals and collectives also need to reflect upon the arbitrariness of their own cultural matrixes. This process is anxiety‐provoking and elicits strong individual and social resistance. Analytic institutions, as well as individual analysts, need to develop tools to look at their own cultural surroundings and their embeddedness in these necessary but arbitrary collective narratives. As analyst‐citizens, we can expand our tools and skills beyond the individual to the large‐group level, to perceive and make conscious our own sociocultural determinants—national and professional ones, historical, and contemporary ones. Intercultural experiences and perspectives can be used to facilitate an insight into the ways cultural narratives shape our identities and bind us to larger collectives. The social unconscious can be brought to light. We can analyze what kind of air was, and is, breathed into us. The author, as a German–American psychoanalyst, uses personal experience to illustrate the necessary working‐through process of analyzing unconscious aspects of the intrapsychic, the interpersonal, and the cultural determinants of our respective individual and collective backgrounds.
Organocatalyzed Modular Synthesis of Polycyclic Dihydropyridines and Pyridines through Sulfamate Linchpin
Authors: Bhajammanavar Vinod , Sureshbabu Popuri , Kesava Reddy Mallu , Baidya Mahiuddin 
Published: May 2022

AbstractThe cascade annulation between alkylidene malononitriles and cyclic sulfamidate imines has been controlled by leveraging the sulfamate functionality under organocatalysis, which allows selective access to polycyclic and densely functionalized dihydropyridines and pyridines in high yields. The protocol is scalable and shows broad substrate scope. The products were also engaged in the preparation of tetracyclic pyridopyrimidines, showcasing the synthetic versatility.
Determining paths of innovation: The role of culture on the adoption on organic farming management
Authors: Manta Francesco , Morrone Domenico , Toma Pierluigi , Campobasso Francesco 
Published: May 2022

AbstractThe aim of this paper is to understand whether national culture is linked with operative performance of organic agriculture. The ultimate goal is, indeed, to measure the impact of social change on technical innovation and sustainability issues. We built an econometric model where the impact of some of the six dimensions of national culture by Geert Hofstede is tested on inputs and outputs of organic production, on a country‐based scale. We collected data about the evolution of organic agriculture through the last two decades, extracting data about 27 countries of the European Union from 2000 to 2017. We tested the dataset into two passages: we first employed a DEA model to assess efficiency of organic farming, and then we correlated results to Hofstede 6‐D model of national culture. We observed the existence of a relationship between culture and innovation, explaining the importance of determined values in people's management within the firm. The operative performance of organic agriculture is linked to determined culturally influenced business values. We used efficiency results as variables for measuring innovation approach based on cultural models. It has been enhanced the relevance to the nexus innovation‐culture approaching to one of the most innovation‐resistant industrial sectors.
Do major customers encourage innovative sustainable development? Empirical evidence from corporate green innovation in China
Authors: Huang Chang , Chang Xiao , Wang Yang , Li Nicolas 
Published: May 2022

AbstractThis paper examines the impact of customer concentration on green innovation in Chinese listed firms between 2006 and 2018 through the dynamic panel generalized method of moments regressions. It is reported that major customers positively impact corporate green innovation, indicating that firms have more incentives to engage in innovative green practices to maintain stable relationships with major customers. In addition, the positive relationship between customer concentration and green innovation is more pronounced in state‐owned enterprises, firms located in the provinces with a high level of marketization, and after China's new Environmental Protection Law implementation. Moreover, we observe that the positive impact of customer concentration on corporate green innovation is more significant among industrial firms and firms operating in heavily polluting industries. Furthermore, industrial competition is an essential channel for major customers to affect corporate green innovation.
Identification of pyroptosis‐related gene prognostic signature in head and neck squamous cell carcinoma
Authors: Li Zhanzhan , Shen Lin , Li Yanyan , Shen Liangfang , Li Na 
Published: May 2022

AbstractBackgroundHead and neck squamous cell carcinoma (HNSCC) is a life‐threatening disease with poor prognosis. Pyroptosis has been recently disclosed as a programmed cell death triggered by invasive infection, involved in cancer development. However, the prognosis role of pyroptosis‐related genes in HNSCC has not been discussed.MethodsThe RNA sequence data of pyroptosis‐related genes were obtained from The Cancer Genome Atlas (TCGA) database. Cox regression and the least absolute shrinkage and selection operator (LASSO) analysis were performed to screen the HNSCC survival‐related signature genes. We established a HNSCC risk model with the identified prognostic genes, then divided the HNSCC patients into low‐ and high‐risk subgroups according to median risk score. Moreover, we utilized Gene Expression Omnibus (GEO) dataset to validate the risk model. Go and KEGG analyses were conducted to reveal the potential function of differential expression of genes that identified between low‐ and high‐risk subgroups. ESTIMATE algorithm was performed to investigate the immune infiltration of tumors. Correlation between signature gene expression and drug‐sensitivity was disclosed by Spearman's analysis.ResultsWe constructed a HNSCC risk model with identified seven pyroptosis‐related genes (CASP1, GSDME, IL6, NLRP1, NLRP2, NLRP6, and NOD2) as prognostic signature genes. High‐risk subgroup of HNSCC patients in TCGA cohort correlated with lower survival probability than patients from low‐risk subgroup (p < .001), and the result is verified with GEO dataset. In addition, 161 genes were identified differentially expressed between the low‐ and high‐risk subgroups in the TCGA cohort, mainly related to immune response. Higher PD‐L1 expression level was found in the high‐risk subgroup that indicated the possible employment of immune checkpoint inhibitors. IL6 was positively correlated with WZ3105 and MPS‐1‐IN‐1 in the cancer therapeutics response portal database.ConclusionWe built and verified a risk model for HNSCC prognosis using seven pyroptosis‐related signature genes, which could predict the overall survival of HNSCC patients and facilitate treatment.
Bromo‐Substituted Diazenyl‐pyrazolo[1,5‐a]pyrimidin‐2‐amines: Sonogashira Cross‐Coupling Reaction, Photophysical Properties, Bio‐interaction and HSA Light‐Up Sensor
Authors: Stefanello Felipe S. , Kappenberg Yuri G. , Araújo Juliane N. , Dozza Bianca , Nogara Pablo A. , Rocha João B. T. , Zanatta Nilo , Martins Marcos A. P. , Bonacorso Helio G. , Iglesias Bernardo A. 
Published: May 2022

AbstractA convenient synthesis of a broad series of thirteen examples of alkyne‐spacer derivatives 2 from the well‐known Sonogashira cross‐coupling reaction on diazenyl‐pyrazolo[1,5‐a]pyrimidin‐2‐amine compounds 1 is reported. The reactivity of heterocycles 1 due the presence of selected electron‐donor (EDG) and electron‐withdrawing (EWG) groups attached to different alkynes was evaluated. Also, the reactional versatility due the position variation of the bromo atom at the scaffolds 1 was also investigated. In general, derivatives presented strong absorption bands at the 250–500 nm optical window and UV to cyan emission properties. Also, the redox analysis was recorded by electrochemical cyclic voltammetry technique. For HSA biomacromolecule assays, spectroscopic studies by UV‐Vis, steady‐state and time‐resolved emission fluorescence, and molecular docking calculations evidenced the ability of each compound to establish interactions with human serum albumin (HSA). Finally, the behavior presented for this new class of heterocycles makes them a promising tool as optical sensors for albumins.
Bone marrow aspiration in a patient with systemic microsporidium
Authors: Gómez Ximena E. , Castillo Jorge J. , Gómez Marco A. 
Published: May 2022

AbstractA 34‐year‐old female presented with several weeks of fever, fatigue, weight loss, abdominal pain and hemoptysis. PE revealed moderate pallor, RUQ pain, mild dyspnea, conjunctival injection and hepatomegaly. The CBC showed anemia, mild leukocytosis, hypoalbuminemia, hypertransaminasemia, presence of nucleated red blood cells. Microsporidium was found in BMA.
Layered Uranyl Phosphonates Encapsulating Co(II)/Mn(II)/Zn(II) Ions: Exfoliation into Nanosheets and Its Impact on Magnetic and Luminescent Properties
Authors: Wen Ge‐Hua , Zou Qian , Xu Kui , Huang Xin‐Da , Bao Song‐Song , Chen Xue‐Tai , Ouyang Zhongwen , Wang Zhenxing , Zheng Li‐Min 
Published: May 2022

AbstractLayered heterometallic 5f–3d uranyl phosphonates can exhibit unique luminescent and/or magnetic properties, but the fabrication and properties of their 2D counterparts have not been investigated. Herein we report three heterobimetallic uranyl phosphonates, namely, [(UO2)3M(2‐pmbH)4(H2O)4] ⋅ 2H2O [MU, M=Co(II), CoU; Mn(II), MnU; Zn(II), ZnU; 2‐pmbH3=2‐(phosphonomethyl)benzoic acid]. They are isostructural and display two‐dimensional layered structures where the M(II) centers are encapsulated inside the windows generated by the diamagnetic uranyl phosphonate layer. Each M(II) has an octahedral geometry filled with four water molecules in the equatorial positions and two phosphonate oxygen atoms in the axial positions. The uranium atoms adopt UO7 pentagonal bipyramidal and UO6 square bipyramidal geometries. The lattice and coordination water molecules can be released by thermal treatment and reabsorbed in a reversible manner, accompanied with changes of magnetic dynamics. Interestingly, the bulk samples of MU can be exfoliated in acetone via freezing and thawing processes forming nanosheets with single‐layer or two‐layer thickness (MU‐ns). Magnetic studies revealed that the CoU and MnU systems exhibited field‐induced slow magnetization relaxation at low temperature. Compared with crystalline CoU, the magnetic relaxation of the CoU‐ns aggregates is significantly accelerated. Moreover, photoluminescence measured at 77 K showed slight red‐shift of the five characteristic uranyl emission bands for ZnU‐ns in comparison with those of the crystalline ZnU. This work gives the first examples of 2D materials based on 5f–3d heterometallic uranyl phosphonates and illustrates the impact of dimension reduction on their magnetic/optical properties.