bluuebunny/crossref_metadata_2025_split huggingface dataset:
PEMBENTUKAN KARAKTER SOPAN MELALUI PEMBIASAAN SENYUM DAN SALAM DI SMA NEGERI 1 CIAMPEL
Authors: MARLINA LENNY 
Published: February 2022

This study aims to determine the character formation of students' manners through habituation of smiles and greetings carried out at SMA Negeri 1 Ciampel, Karawang Regency. This type of research is field research or field research where researchers go directly to the field to obtain data and information related to the research carried out with the aim of describing a process that occurs in the field. While the approach taken is a qualitative approach. Methods of data collection in the form of observation, interviews, and documentation. The data analysis technique uses inductive analysis with data reduction steps, data presentation and conclusion drawing. From the results obtained in this study, the authors found that the character building carried out by teachers to students through the method of habituation of smiles and greetings was carried out both in the learning process in the classroom and outside the classroom in the SMAN 1 Ciampel school environment, Karawang Regency, went as planned and realized well.
ABSTRAKPenelitian ini bertujuan untuk mengetahui pembentukan karakter sopan santun peserta didik melalui pembiasaan senyum dan salam yang dilaksanakan di SMA Negeri 1 Ciampel Kabupaten Karawang. Jenis penelitian ini adalah penelitian lapangan atau field research dimana peneliti turjun langsung ke lapangan untuk memperoleh data dan informasi terkait dengan penelitian yang dilakukan dengan tujuan menggambarkan suatu proses yang terjadi di lapangan. Sedangkan pendekatan yang dilakukan adalah pendekatan kualitatif. Metode pengumpulan data berupa obsevasi, wawancara, dan dokumentasi. Teknik análisis data menggunakan análisis induktif dengan langkah reduksi data, penyajian data dan penarikan kesimpulan. Dari hasil yang diperoleh dalam penelitian ini penulis menemukan pembentukan karakter yang dilakukan para guru kepada peserta didik melalui metode pembiasaan senyum dan salam yang dilakukan baik dalam proses pembelajaran di dalam kelas maupun diluar kelas dilingkungan sekolah SMAN 1 Ciampel Kabupaten Karawang, berjalan sesuai yang direncanakan dan terwujud dengan baik.
ESPÉCIES AMEAÇADAS: O ESTUDO DE CASO DO PODER PÚBLICO EM DEFESA DO MEIO AMBIENTE
Authors: Menezes Gláucio Costa de , Fontgalland Isabel Lausanne 
Published: February 2022

Ao longo do período 1981-2021, a legislação ambiental brasileira foi sendo estruturada e atualizada, de forma que atualmente, é um dos mais completos conjuntos de leis ambientais do mundo. A preservação da fauna, punindo ações criminosas, praticadas por indivíduos que exercem atividades ilegais, está pautada nas Leis nº 9.605/1998 e nº 5.197/1969. Sendo assim, o objetivo do estudo em tela foi analisar a atuação da Polícia Militar, na proteção de espécies ameaçadas e seus ecossistemas em perigo no Estado da Paraíba, de maneira a subsidiar a tomada de decisão dos órgãos operativos de preservação e proteção do meio ambiente. Utilizou-se por método de estudo – o estudo de caso, satisfatoriamente adequado para responder as subsequentes indagações à presente pesquisa. Outrossim, o trabalho aqui proposto é revestido de relevância científica e social, podendo servir de base para avanços na proteção ambiental, no combate ao tráfico de animais silvestres e na garantia dos direitos da sociedade a um meio ambiente equilibrado, bem como para outros estudos nas áreas de Direito Ambiental, Segurança Pública e de Gestão de Recursos Naturais.
Comparing black-carbon- and aerosol-absorption-measuring instruments – a new system using lab-generated soot coated with controlled amounts of secondary organic matter
Authors: Kalbermatter Daniel M. , Močnik Griša , Drinovec Luka , Visser Bradley , Röhrbein Jannis , Oscity Matthias , Weingartner Ernest , Hyvärinen Antti-Pekka , Vasilatou Konstantina 
Published: February 2022

Abstract. We report on an inter-comparison of black-carbon- and
aerosol-absorption-measuring instruments with laboratory-generated soot
particles coated with controlled amounts of secondary organic matter (SOM).
The aerosol generation setup consisted of a miniCAST 5201 Type BC burner for
the generation of soot particles and a new automated oxidation flow reactor
based on the micro smog chamber (MSC) for the generation of SOM from the
ozonolysis of α-pinene. A series of test aerosols was generated with elemental to total carbon (EC / TC) mass fraction ranging from about 90 % down to 10 % and single-scattering albedo (SSA at 637 nm) from almost 0 to about 0.7. A dual-spot Aethalometer AE33, a photoacoustic extinctiometer
(PAX, 870 nm), a multi-angle absorption photometer (MAAP), a prototype
photoacoustic instrument, and two prototype photo-thermal interferometers
(PTAAM-2λ and MSPTI) were exposed to the test aerosols in parallel.
Significant deviations in the response of the instruments were observed
depending on the amount of secondary organic coating. We believe that the
setup and methodology described in this study can easily be standardised and provide a straightforward and reproducible procedure for the
inter-comparison and characterisation of both filter-based and in situ black-carbon-measuring
(BC-measuring) instruments based on realistic test aerosols.
BALANTIDIUM COLI infection, immune status and comorbidities: literature review
Authors: Silva de Oliveira (§) Amanda , Gómez-Hernández (§) César , Rezende-Oliveira Karine 
Published: February 2022

ABSTRACT Balantidiasis, a disease caused by the ciliated protozoan Balantidium coli, mainly infects thelarge intestine and may present intestinal spread. The purpose of this literature review was to study the infection by B. coli and comorbidities to identify the factors that can contribute to the establishment of the disease. In this review, we attempt to explore and describe the various comorbidities associated with B. coli infection. We reviewed the literature based on comorbidities with a focus on the association with B. coli infection. The primary platforms targeted were PubMed, LILACS, SciELO and Google Scholar. Studies published between 1990 and 2020 in Portuguese, English, and Spanish were considered. The comorbidities reported in the papers were diverse, associating infection by B. coli with the immunosuppression that they generate. The intestinal microbiota may also play an important role, because when dysbiosis is present, its composition and structure are affected, which may enable the invasion of the mucosa. The review shows that the presence of the parasite and establishment of balantidiasis can influence in the clinical stage of chronic and autoimmune diseases, considering themodulation of the immune response in presence of B. coli.KEY WORDS: Balantidium coli; autoimmunity; balantidiosis; comorbidities; immunodepression.
SISTEM INFORMASI EKSTRAKURIKULER BERBASIS WEBSITE MENGGUNAKAN SYSTEM DEVELOPMENT LIFE CYCLE (SDLC) PADA SMAN 16 GOWA
Authors: Lestari Perdana Ayu , Suharni Suharni 
Published: February 2022

Perkembangan teknologi dalam dunia pendidikan sangat penting dalam membangun manusia Indonesia seutuhnya. Penelitian ini bertujuan untuk mengevaluasi sistem informasi sekolah pada kegiatan organisasi ekstrakurikuler di SMAN 16 Gowa. Pengelolaan anggota organisasi di sekolah yang sebelumnya menggunakan pencatatan manual menjadi komputerisasi berbasis web. Metode yang digunakan dalam penelitian ini adalah System Development Life Cycle (SDLC) yaitu metodologi klasik yang digunakan untuk mengembangkan, memelihara dan menggunakan sistem informasi. Adapun tahapan-tahapan System Development Life Cycle (SDLC) yaitu perencanaan sistem, analisis sistem, desain sistem, Implementasi sistem serta operasi dan pemeliharaan. Hasil penelitian menunjukkan bahwa Website ekstrakurikuler pada SMAN 16 Gowa menjadi sumber informasi ekstrakurikuler, memberikan informasi mengenai jumlah siswa yang mengikuti ekstrakurikuler, jadwal maupun kegiatan ekstrakurikuler dan media pendaftaran ekstrakurikuler sehingga siswa mampu mendaftar secara online tanpa harus registrasi secara langsung. Fitur-fitur yang dimiliki yaitu jadwal kegiatan ekstrakurikuler, prestasi ekstrakurikuler, galeri ekstrakurikuler dan fitur chat dengan ketua ekstrakurikuler. Sistem Informasi yang dibangun ini mempermudah dalam penginputan dan sesuai dengan sistem yang diusulkan. Pengujian dan implementasi sistem ini sesuai dengan hasil yang diharapkan dimana fungsional input dan output sistem berfungsi dengan baik untuk menggantikan sistem manual yang selama ini digunakan.
Síndrome de Paget-Schrötter. Presentación de un caso
Authors: Rojas Padilla Daniel Antonio , Rueda Chaparro Helí de Jesús , Durán Gómez Miguel Eduardo , Uriza Carrasco Luis Felipe 
Published: February 2022

El síndrome Paget-Schrötter se define como la trombosis venosa profunda primaria de las extremidades superiores, atribuible a anomalías anatómicas obstructivas en la vena axilar o subclavia que alteran el retorno venoso, o por un esfuerzo muscular intenso. Por lo general, se presenta en adultos jóvenes sin antecedentes y se expresa clínicamente como dolor, edema espontáneo y grave de las extremidades superiores luego de una actividad física vigorosa, asociado a parestesias, debilidad y cianosis. Para el diagnóstico se necesita la combinación de la probabilidad clínica, el resultado del dímero D y la ultrasonografía. Su incidencia es aproximadamente de 1 a 2 personas por 100.000 habitantes al año y afecta a ambos sexos. A continuación se presenta el caso de un paciente con síndrome de Paget-Schrötter que consultó al servicio de urgencias en un hospital de tercer nivel.
C. elegans as an in vivo model system for the phenotypic drug discovery for treating paraquat poisoning
Authors: Ji Peng , Li Hongyuan , Jin Yushan , Peng Yinghua , Zhao Lihui , Wang Xiaohui 
Published: February 2022

Background
Paraquat (PQ) is an effective and widely used herbicide and causes numerous fatalities by accidental or voluntary ingestion. However, neither the final cytotoxic mechanism nor effective treatments for PQ poisoning have been discovered. Phenotypic drug discovery (PDD), which does not rely on the molecular mechanism of the diseases, is having a renaissance in recent years owing to its potential to address the incompletely understood complexity of diseases. Herein, the C. elegans PDD model was established to pave the way for the future phenotypic discovery of potential agents for treating PQ poisoning.

Methods
C. elegans were treated with PQ-containing solid medium followed by statistical analysis of worm survival, pharyngeal pumping, and movement ability. Furthermore, coenzyme Q10 (CoQ10) was used to test the C. elegans model of PQ poisoning by measuring the levels of reactive oxygen species (ROS) and malondialdehyde (MDA), mitochondrial morphology, and worm survival rate. Additionally, we used the classic mice model of PQ intoxication to evaluate the validity of the C. elegans model of PQ poisoning by measuring the effect of CoQ10 as a potential antidote for PQ poisoning.

Results
In the C. elegans model of PQ poisoning, 5 mg/mL PQ increased the levels of ROS, MDA content, mitochondrial fragments, which significantly shortened the lifespan, while CoQ10 alleviated these phenotypes. In the mice model of PQ poisoning, CoQ10 increased the chance of survival in PQ poisoned mice while reducing ROS, MDA content in lung tissue and inhibiting PQ-induced lung edema. Moreover, CoQ10 alleviated the lung morphopathological changes induced by PQ.

Conclusion
Here we established a C. elegans model of PQ poisoning, whose validity was confirmed by the classic mice model of PQ intoxication.
Evolutionary Sequence of Spacetime and Intrinsic Spacetime and Associated Sequence of Geometries in Metric Force Fields II
Authors: Joseph O. Akindele Adekugbe 
Published: February 2022

The geometry of curved ‘three-dimensional’ absolute intrinsic metric space (an absolute intrinsic Riemannian metric space) \(\varnothing\hat{\mathbb{M}}^3\), which is curved (as a curved hyper-surface) toward the absolute time/absolute intrinsic time ‘dimensions’ (along the vertical), and projects a flat three-dimensional absolute proper intrinsic metric space \(\varnothing\hat{\mathbb{E}}^\prime\)ab3 and its outward manifestation namely, the flat absolute proper 3-space \(\hat{\mathbb{E}}^\prime\)ab3, both as flat hyper-surfaces along the horizontal, isolated in the first part of this paper, is subjected to graphical analysis. Two absolute intrinsic metric tensor equations, one of which is of the form of Einstein free space field equations and the other which is a tensorial statement of absolute intrinsic local Euclidean invariance (A\(\varnothing\)LEI) on \(\varnothing\hat{\mathbb{M}}^3\), are derived. Simultaneous (algebraic) solution to the equations yields the absolute intrinsic metric tensor and the absolute intrinsic Ricci tensor of absolute intrinsic Riemann geometry on the curved \(\varnothing\hat{\mathbb{M}}^3\), in terms of a derived absolute intrinsic curvature parameter. A superposition procedure that yields the resultant absolute intrinsic metric tensor and the resultant absolute intrinsic Ricci tensor, when two or a larger number of absolute intrinsic Riemannian metric spaces co-exist (or are superposed) is developed.
The fact that a curved ‘three-dimensional’ absolute intrinsic metric space \(\varnothing\hat{\mathbb{M}}^3\) is perfectly isotropic and is consequently contracted to a ‘one-dimensional’ isotropic absolute intrinsic metric space, denoted by \(\varnothing\hatρ^3\), which is curved toward the absolute time/absolute intrinsic time ’dimensions’ (\(\hat{c}\)\(\hat{t}\)/\(\varnothing\)\(\hat{c}\)\(\varnothing\)\(\hat{t}\)) along the vertical is derived.
origins of the settlements at Kelso and Peebles, Scottish Borders
Authors: Perry David , Dixon Piers , Mackenzie James , Sharman Paul , Cox Adrian , Hall Derek , Smith Catherine , Spoerry Paul , Wickham-Jones Caroline , Gallagher Dennis , Ford Barbara , Henderson D , Tarling D , Crowdy Amanda , Moffatt Brian , Bateson Donald 
Published: February 2022

This is a report on archaeological work in two of Scotland's less well-known medieval burghs of Kelso and Peebles (NGR: NT 7268 3402; NT 7261 3408; NT 2520 4053; NT 2057 4051).
The excavations at Wester Kelso/Floors Castle established that the original medieval burgh of Kelso or Wester Kelso was much further west than previously believed, being situated well inside the present Castle policies. That early settlement at Wester Kelso appears to have been abandoned in the 14th or 15th centuries, at the same time that the royal burgh of Roxburgh was deserted, probably as a result of the English occupation of Roxburgh Castle. The other settlement of Easter Kelso, near the abbey, survived and expanded northwards from the abbey along Roxburgh Street. The finding of a possible building terrace in Phase 1 at 13–19 Roxburgh Street indicates that settlement along the southern end of that street could date to as early as the 13th or 14th centuries. Combining the archaeological, cartographic and documentary evidence, it seems clear that 'Easter' Kelso, now Kelso, had expanded from the market area around the abbey northwards towards the Floors estate by the early 18th century. The excavations in Peebles have provided important information on the origins of the settlement of the peninsular ridge between the Tweed and Eddleston Water. The results obtained from the excavations at the two sites in Peebles indicate that settlement of the ridge began in the 12th century, soon after the establishment of the royal castle and burgh by David I (1124–53). At both sites, after initial dumping of rubbish, possibly to raise the ground level to counter flooding, occupation, in the form of stone structures, can be dated to the 14th century at the latest, with probable earlier dumping of domestic refuse in the 12th and 13th centuries. The street of Bridgegate was apparently laid out in the 13th or 14th centuries when the excavated site was divided into three properties aligned on that street, two of which had stone buildings erected on them. Alternatively, Bridgegate may have been the initial focus of settlement on the east side of the Eddleston, providing the access route from the east into Old Town, where a pilgrimage centre had been established at the Cross Kirk in 1261, and the location of the tolbooth (Bridgegate Building 4) in it suggests that this street was originally more important than High Street. It is noteworthy that all eight medieval buildings excavated at the two Peebles sites were of stone construction. Peebles tolbooth, the civic centre of the burgh, is the only medieval tolbooth site in Scotland to have been excavated.
Effect of Phenolic Substituent Position in Boron Complexes of Imidazo[1,5‐a]pyridine
Authors: Yagishita Fumitoshi , Hoshi Keita , Mukai Shoma , Kinouchi Takashi , Katayama Tetsuro , Yoshida Yasushi , Minagawa Keiji , Furube Akihiro , Imada Yasushi 
Published: February 2022

AbstractWe have synthesized two boron complexes of 3‐(o‐hydroxyphenyl)imidazo[1,5‐a]pyridine exhibiting blue emission in solution. The transient absorption and theoretical studies of the complexes and their 1‐(o‐hydroxyphenyl) substituted isomers revealed that the phenolic substituent position in boron complex of imidazo[1,5‐a]pyridine affected the excites state dynamics involved in photoluminescence (PL). Although the introduction of phenolic substituent at 1‐position of the boron complex is effective to achieve the strong emission, the introduction of phenolic substituent at 3‐position results in the decreasing PL quantum yield due to intersystem crossing from the singlet excited state to the triplet excited state.
Cortical structure and episodic memory profiles in APOE ε4: Resilience and vulnerability for cognitive impairment
Authors: Coughlan Gillian , Zhukovsky Peter , Voineskos Aristotle N , Grady Cheryl 
Published: February 2022

AbstractBackgroundThe apolipoprotein E (APOE)‐ε4 allele represents the greatest genetic risk factor for late‐onset Alzheimer’s disease (AD). Identifying a resilience profile that might mitigate medial temporal lobe atrophy in enriched genetic risk may explain differences between individuals’ susceptibility to AD pathology.Method742 older adults from OASIS‐3 were stratified by APOE genotype status (423 ε3ε3 carriers; 271 ε3ε4 carriers and 48 ε4ε4 carriers) and classified as cognitively normal (74%) or with mild cognitive dysfunction (26%) using the clinical dementia rating scale (CDR) score. Neuropsychological screening measured general cognitive function, depression and psychiatric symptoms. Episodic memory, processing speed and naming ability were included as cognitive outcome measures. Cortical structure was measured using FreeSurfer. General linear models determined the main effects of APOE and cognitive status on relative regional volumes (regional volume divided by total intracranial volume) and cognition. APOE x cognitive status interactions were followed up with linear models to assess the effects of APOE in the cognitively normal and impaired groups separately.ResultAs expected main effects of APOE and cognitive status were observed on hippocampal, amygdala and entorhinal volumes. Greater effects of APOE were found on all regions in individuals with cognitive dysfunction, except on the entorhinal cortex. Significant interactions between APOE and cognitive status revealed that the left precuneus and superior frontal volumes were preserved in cognitively normal homozygote and heterozygote ε4 carriers with entorhinal atrophy, but were reduced in cognitively impaired ε4 carriers, controlling for age and sex. We found a similar interactive effect of APOE and cognitive status on episodic memory, with superior memory in cognitively normal e4ε4 carriers, and memory impairment in cognitively impaired e4ε4carriers, compared to their respective cognitive normal and impaired ε3ε3 counterparts.ConclusionCortical and subcortical atrophic signatures were identified for cognitively normal and impaired ε4 carriers. Structural integrity of the precuneus and superior frontal cortices may protect against cognitive dysfunction, even if medial temporal atrophy is present. Thus, our results indicate that the structural integrity of frontal‐parietal lobes may provide resilience against cognitive impairment in the face of ε4‐related decline in medial temporal structures.
Methods and future directions for evaluation of Tau PET signal
Authors: Pontecorvo Michael J. , Devous Michael D. , Lu Ming , Fleisher Adam S. , Collins Emily C. , Mintun Mark A. 
Published: February 2022

AbstractBackgroundAlzheimer’s disease (AD) is defined in vivo by evidence of amyloid and tau, usually accompanied by neurodegeneration, in accordance with the ATN criteria.MethodDeposition of amyloid is thought to begin early in the disease process and, by the time symptoms become evident, can usually be detected as elevated PET signal in a stereotypical pattern across regions. In contrast tau deposition begins later in disease and the pattern and timing of evolution of tau deposition may vary across individuals. Thus, it is more difficult to assign a classification of tau positive that fits all purposes.ResultStudies in autopsy confirmed patients indicate that tau PET visual interpretation methods may be effective in identifying subjects at the B3 (Braak V/VI) stage of deposition. B3 tau deposition is typically also associated with amyloid positivity, thus predicting a likely pathological diagnosis of high AD neuropathologic change at autopsy. However, a negative visual interpretation cannot rule out the presence of amyloid and tau levels sufficient to support a classification of intermediate AD neuropathological change. Quantitative methods focused on temporal lobe (particularly inferior and mesial temporal lobe) may be more sensitive to earlier stages of AD tau deposition, but confirmation of amyloid status may be required to rule out primary age‐related tauopathy.ConclusionTogether visual and quantitative interpretation methods may identify patterns of tau distribution and density with implications for the expression of symptoms, and future progression of impairment, and may be of value in stratifying/selecting patients most likely to respond in clinical trials of AD therapeutics.