bluuebunny/crossref_metadata_2025_split huggingface dataset:
A practical manner to GTR recycling in waste-HDPE/ABS
Authors: Heller Balázs , Simon-Stőger Lilla , Makó Éva , Varga Csilla 
Published: July 2022

AbstractWaste high-density polyethylene (w-HDPE)/ acrylonitrile–butadiene–styrene (ABS)/ground tire rubber (GTR) have been melt blended by two-roll milling. Ternary blends of w-HDPE/ABS/GTR have been observed to be incompatible in the composition range studied which revealed in the deteriorated mechanical properties. Two main types of compatibilizers such as an experimental olefin-maleic anhydride copolymer based one synthesized by the authors and a commercial maleic anhydride grafted polypropylene (MA-g-PP) have been chosen for enhancing compatibility between the components ergo the mechanical properties. For characterizing tensile and impact properties of the blends mechanical tests have been carried out besides the scanning electron microscopy (SEM), X-ray diffraction and Fourier transform infrared spectroscopy. The most advantageous result in industrial practice can be that the experimental additive allows to apply higher GTR concentration ergo gives the opportunity to recycle higher level of GTR.
Men are from Mars, women are from Venus: on lenders’ stereotypical views and the implications for a firm’s debt
Authors: Bannò Mariasole , D’Allura Giorgia Maria , Coller Graziano , Varum Celeste 
Published: July 2022

AbstractBuilding on social construction theory, this paper investigates how the presence of women on the board may affect access to credit because of lenders’ gender-stereotyped views. In our view this translates into different levels of the firm's bank debt. To evaluate the impact of gender as a social construct, we designed a within-country analysis in Italy by distinguishing between egalitarian and non-egalitarian contexts. To test our hypotheses, we used a sample of 3514 Italian listed and unlisted firms. Results showed a lower level of bank debt for firms with a relevant number of women in the boardroom (i.e., critical mass) if located in a non-egalitarian context. This effect was partially mitigated in firms during a crisis situation. While extant research explains gender-based differences in a firm’s financial structure by a change in inner-board mechanism/dynamics caused by differences in men/women characteristics, we argue that the social construction of gender may also induce lenders in different contexts to view boards with women differently in relation to access to credit.
Thallium accumulation and distribution in Silene latifolia (Caryophyllaceae) grown in hydroponics
Authors: Corzo Remigio Amelia , Nkrumah Philip Nti , Pošćić Filip , Edraki Mansour , Baker Alan J. M. , van der Ent Antony 
Published: July 2022

Abstract
Purpose
Thallium (Tl) is one of the most toxic elements known and its contamination is an emerging environmental issue associated with base metal (zinc-lead) mining wastes. This study investigated the nature of Tl tolerance and accumulation in Silene latifolia, which has so far only been reported from field-collected samples.

Methods
Silene latifolia was grown in hydroponics at different Tl concentrations (0, 2.5, 5, 30 and 60 μM Tl). Elemental analysis with Inductively coupled plasma atomic emission spectroscopy (ICP-AES) and laboratory-based micro-X-ray fluorescence spectroscopy (μ-XRF) were used to determine Tl accumulation and distribution in hydrated organs and tissues.

Results
This study revealed unusually high Tl concentrations in the shoots of S. latifolia, reaching up to 35,700 μg Tl g−1 in young leaves. The species proved to have exceptionally high levels of Tl tolerance and had a positive growth response when exposed to Tl dose rates of up to 5 μM. Laboratory-based μXRF analysis revealed that Tl is localized mainly at the base of the midrib and in the veins of leaves. This distribution differs greatly from that in other known Tl hyperaccumulators.

Conclusions
Our findings show that S. latifolia is among the strongest known Tl hyperaccumulators in the world. The species has ostensibly evolved mechanisms to survive excessive concentrations of Tl accumulated in its leaves, whilst maintaining lower Tl concentrations in the roots. This trait is of fundamental importance for developing future phytoextraction technologies using this species to remediate Tl-contaminated mine wastes.
Obesity, type 2 diabetes, and testosterone in ageing men
Authors: Wittert Gary , Grossmann Mathis 
Published: July 2022

AbstractIn the absence of obesity, adverse lifestyle behaviours, and use of medication such as opioids serum testosterone concentrations decrease by only a minimal amount at least until very advanced age in most men. Obesity is heterogeneous in its phenotype, and it is the accumulation of excess adipose tissue viscerally associated with insulin resistance, dyslipidaemia, inflammation, hypothalamic leptin resistance and gliosis that underpins thefunctional hypogonadismof obesity. Both central (hypothalamic) and peripheral mechanisms are involved resulting in a low serum total testosterone concentration, while LH and FSH are typically in the normal range. Peripherally a decrease in serum sex hormone binding globulin (SHBG) concentration only partially explains the decrease in testosterone and there is increasing evidence for direct effects in the testis. Men with obesity associated functional hypogonadism and serum testosterone concentrations below 16 nmol/L are at increased risk of incident type 2 diabetes (T2D); high testosterone concentrations are protective. The magnitude of weight loss is linearly associated with an increase in serum testosterone concentration and with the likelihood of preventing T2D or reverting newly diagnosed disease; treatment with testosterone for 2 years increases the probability of a positive outcome from a lifestyle intervention alone by approximately 40%. Whether the additional favourable benefits of testosterone treatment on muscle mass and strength and bone density and quality in the long-term remains to be determined.
The Use of Balanced Scorecards in Mental Health Services: an Integrative Review and Thematic Analysis
Authors: Brimelow Rachel E. , Amalathas Aneline , Beattie Elizabeth , Byrne Gerard , Dissanayaka Nadeeka N. 
Published: July 2022

Abstract
Performance management of mental health services (MHS) through quality reporting of strategic indicators and goals is essential to improve efficiency and quality of care. One such method is the balanced scorecard (BSC). This integrative review of peer-reviewed and industry implemented BSCs in MHS aims to inform future development of a more comprehensive mental health–focused benchmarking tool. A two-part systematic literature search consisted of peer-reviewed published literature on MHS specific BSCs utilising the PRISMA guidelines in addition to industry published BSCs available online. A total of 17 unique BSCs were identified. A total of 434 indicators were subject to thematic analysis identifying 11 key themes: prevalence, accessibility, services provided, clinical outcomes, client satisfaction, client involvement, staff motivation, staffing levels, governance and compliance, development, and costs and revenue. These themes represented the measures that MHS believed measured key performance criteria in alignment with their organisational objectives.
The impact of Digitalized Communication on the effectiveness of Local Administrative Authorities – Findings from Central European Countries in the COVID-19 Crisis
Authors: Hirsch Bernhard , Schäfer Fabienne-Sophie , Aristovnik Aleksander , Kovač Polonca , Ravšelj Dejan 
Published: July 2022

AbstractThis paper analyses the impact of the use of digital communication tools in administrative procedures on the effectiveness of local administrative authorities during the COVID-19 pandemic. It considers COVID-19-driven changes in the legal competence of the institutional unit and administrative authorities’ orientation to good governance as mediators of this relationship. By applying partial least squares structural equation modelling (PLS-SEM) to survey data (N = 610) from five central European countries, we show that the accelerated use of digitalized communication tools driven by the COVID-19 situation has a positive effect on the effectiveness of local administrative authorities. Our data also indicate that the new laws, instructions and good governance driven by the COVID-19 situation – based on mostly convergent administrative traditions and European trends – partially mediate the relationship between the use of digital communication tools and administrative effectiveness. These findings do not significantly differ between participating countries and bureaucratic traditions. Consequently, the COVID-19 crisis proved to be a joint facilitator of responsive public governance that remained compliant with the rule of law, regardless of whether the national administrative systems were traditionally more legalistically or managerially oriented.
Anxiety in the mathematics classroom: reciprocal relations with control and value, and relations with subsequent achievement
Authors: Putwain David W. , Wood Peter 
Published: July 2022

AbstractStudents’ attitudes can be influential in the emotions experienced in mathematics learning and achievement at school. Two important judgements, according to Control-Value Theory are degree of control a student has over, and the value attached to, learning activities or outcomes. Appraisals of control and value are believed to play a central role in the emotions experienced when learning, and subsequent achievement. Achievement, in turn, can strengthen or weaken control-value appraisals. In the present study we set out to examine the bidirectional relations between control-value appraisals and a key emotion experienced in the mathematics classroom, namely anxiety. In addition, we tested the proposition that control-value appraisals are indirectly linked to achievement, mediated by classroom-related anxiety. The participants were 1242 Year 5 students (49% female), with a mean of 9.3 years, from 24 English primary schools. Self-report data for anxiety, and control-value appraisals, were collected over two waves (separated by seven months) and mathematics achievement collected from a classroom test one week later. Results from a structural equation model showed bidirectional relations between higher anxiety and lower control. Although anxiety predicted lower value, value was unrelated to subsequent anxiety. Higher control at the first wave of measurement was related to higher mathematics achievement, mediated by lower anxiety, at the second wave. These results underscore the importance of reducing anxiety when learning mathematics and suggest that intervention could achieve this outcome by reducing anxiety directly or by strengthening control.
Evaluating Return-to-Work Programmes after Critical Incidents: a Review of the Evidence
Authors: Sutton Anna , Polaschek Devon L. L. 
Published: July 2022

Abstract
In most countries, employers have a responsibility to ensure the safety and well-being of their employees, including those who work in hazardous occupations. Policing can be a hazardous occupation and officers can face physical threats to life. Yet in the police service, there appears to be a dichotomy between treating officers involved in critical incidents solely in terms of serious clinical issues (e.g. PTSD) whilst simultaneously setting a strong expectation that these officers will return to work quickly and with little effect on their work performance. We review the research literature on return-to-work programmes to establish how much the effect of critical incidents on officers’ work performance is being considered and to identify future research directions. Findings indicate an emphasis on improving mental health but a lack of research into occupational outcomes. They also reveal distinct promise for peer-led reintegration programmes.
Statins inhibit proliferation and induce apoptosis in triple-negative breast cancer cells
Authors: O’Grady Shane , Crown John , Duffy Michael J. 
Published: July 2022

AbstractTP53 (p53) is mutated in 80–90% of cases of triple-negative breast cancer (TNBC). Statins, which are widely used to treat elevated cholesterol, have recently been shown to degrade mutant p53 protein and exhibit anti-cancer activity. The aim of this work was to evaluate the potential of statins in the treatment of TNBC. The anti-proliferative effects of 2 widely used statins were investigated on a panel of 15 cell lines representing the different molecular subtypes of breast cancer. Significantly lower IC50 values were found in triple-negative (TN) than in non-TN cell lines (atorvastatin, p < 0.01; simvastatin p < 0.05) indicating greater sensitivity. Furthermore, cell lines containing mutant p53 were more responsive to both statins than cell lines expressing wild-type p53, suggesting that the mutational status of p53 is a potential predictive biomarker for statin response. In addition to inhibiting proliferation, simvastatin was also found to promote cell cycle arrest and induce apoptosis. Using an apoptosis array capable of detecting 43 apoptosis-associated proteins, a novel protein shown to be upregulated by simvastatin was the IGF-signalling modulator, IGBP4, a finding we confirmed by Western blotting. Finally, we found synergistic growth inhibition between simvastatin and the IGF-1R inhibitor, OSI-906 as well as between simvastatin and doxorubicin or docetaxel. Our work suggests repurposing of statins for clinical trials in patients with TNBC. Based on our findings, we suggest that these trials investigate statins in combination with either doxorubicin or docetaxel and include p53 mutational status as a potential predictive biomarker.
#Ownvoices, Disruptive Platforms, and Reader Reception in Young Adult Publishing
Authors: Rutherford Leonie , Johanson Katya , Reddan Bronwyn 
Published: July 2022

AbstractThe concept of #ownvoices writing has gained traction in contemporary publishing as both a genre of reader interest and a focus for debates about authors’ rights to write cross-culturally. This paper examines tensions the #ownvoices movement reveals between the commissioning, publishing, and critical reception of a book, using debate about Craig Silvey’s Honeybee, an Australian novel focalized through a young trans protagonist but written by a straight male author. Drawing on the theory of recognition, it analyzes author and publisher media interviews, social media, and literary reviews in mainstream publications, which are given context through with selected interviews with Australian publishers. Misrepresentation and appropriation are concerns for many readers, while judgements about aesthetic quality vary. Structures within the book industries limit the economic representation of diverse creators which, in turn, has implications for the diversity of experience represented in young adult fiction and its literary quality.
Heritage Value and Stakeholders’ Perception of Four Geomorphological Landscapes in Southern Iceland
Authors: Bussard Jonathan , Reynard Emmanuel 
Published: July 2022

AbstractThis paper has two main objectives: (1) to assess the heritage value of four geomorphological landscapes in Southern Iceland from a geomorphological perspective and (2) to see to what extent the heritage values assigned by different local stakeholders overlap with this assessment. The concept of “geomorphological landscape”, that we define as a landscape whose geomorphological component is of heritage interest, is a scale of analysis that can be understood by different groups of people and that reflects subjective perceptions of the landscape. The evaluation of the heritage value of four geomorphological landscapes has shown that their geoscientific, aesthetic and cultural values are particularly high. Indeed, thanks to their rarity, representativeness, integrity and paleogeographic interest, all four sites have a geoscientific value ranging from 0.81 to 0.94 (the maximum possible score is 1). They also constitute spectacular and beautiful landscapes and have acquired a relevant cultural value because of the major impacts that volcanic eruptions and glaciers advances have had on the local population. Not surprisingly, the heritage awareness of managers of protected areas is high. The interviews also show that other types of stakeholders, such as tourism services providers, tourism promoters and representatives of local authorities, are also aware, to some extent, of the high geoscientific value. The societal and institutional recognition of the heritage value of these geomorphological landscapes is closely linked to their use as territorial resources for tourism.
Prospective evaluation of cardiac effects of first-time marathon training, running, and recovery in middle-aged men: cohort study rationale and design
Authors: Laily I. , Wiggers T. G. H. , van Steijn N. , Verhagen E. , Bakermans A. J. , Jorstad H. T. 
Published: July 2022

Abstract
Background
Several phenomena may point to potentially detrimental cardiac effects of endurance exercise, such as elevated circulating cardiac troponin levels and reductions in systolic and diastolic function directly after marathon completion. Furthermore, while myocardial abnormalities have been reported in patients who recovered from COVID-19, the cardiac impact of extensive endurance exercise in individuals who recovered from COVID-19 remains unknown. We therefore aim to investigate (potentially detrimental) cardiac effects of first-time marathon training and participation, including a subset of participants who recovered from COVID-19, in apparently healthy middle-aged men.

Study design
This exploratory prospective cohort study investigates cardiac effects of first-time marathon running in 24 middle-aged (35–50 years) healthy men. Primary outcomes are cardiac morphological changes from pre-training up to 1 month after marathon completion, measured with magnetic resonance imaging (MRI) at 4 time points: 1) baseline (4 months before the marathon), 2) pre-marathon (2 weeks before the marathon), 3) post-marathon (< 24 h post-marathon), and 4) recovery (4 weeks after the marathon). Secondary parameters include other cardiac or non-cardiac changes: 1) quantitative MRI myocardial mapping, including mean diffusivity and extracellular volume fraction, 2) echocardiographic morphology and function changes, 3) VO2max, 4) electrocardiogram changes, and 5) levels of cardiac biomarkers.

Discussion
This study will contribute to our understanding of cardiac adaptations and maladaptations to first-time marathon running in middle-aged men, and the interaction between extreme endurance exercise and potential detrimental cardiac effects, also in the context of COVID-19. Results will inform on future research directions while providing new clinical insights for health professionals involved in athlete care.
Personality profile of amateur team handball referees
Authors: Dodt Marcus , Fasold Frowin , Memmert Daniel 
Published: July 2022

AbstractReferees play a central role in competitive sport. Particularly in amateur sport, referees contribute significantly to making participation in sport possible for the masses. However, considering that every referee’s career starts at the grassroots level, it is very surprising that there has been no research on the personality traits of amateur referees so far. The current state of research indicates that personality is an essential component of the requirement profile of referees. Personality has been associated with job performance, particularly with regard to resilience and coping with pressure. Personality also affects effective game management in terms of influencing actions in the game in a preventative and proactive manner. This study, therefore, examines the personality profile of amateur handball referees (n = 582) for the first time using the German version of the Big Five Inventory 2 (BFI-2). Current data from German handball referees at the expert level and the German general population were used to compare and discuss the results. Except for lower scores in the domain of extraversion and the facets of sociability and energy level as well as a higher score in the facet of aesthetic sensitivity, amateur referees did not differ significantly from expert referees. In relation to the general population, the results indicate that handball referees, regardless of performance level, have higher scores in assertiveness, emotional stability, and responsibility. Our findings create awareness of personality traits in handball refereeing and illustrate the applied relevance of personality research, e.g., for coaching or recruitment activities.
Integrated in silico analysis of LRP2 mutations to immunotherapy efficacy in pan-cancer cohort
Authors: Li Chunbo , Ding Yan , Zhang Xuyin , Hua Keqin 
Published: July 2022

Abstract
Purpose
Immunotherapy has emerged as a novel therapy, while many patients are refractory. Although, several biomarkers have been identified as predictive biomarkers for immunotherapy, such as tumor specific genes, PD-1/PD-L1, tumor mutation burn (TMB), and microsatellite instability (MSI), results remain unsatisfactory. The aim of this study is to evaluate the value of LRP2 mutations in predicating cancer immunotherapy.

Methods
We investigated the characteristics of low-density lipoprotein receptor-related protein 2 (LRP2) mutation in the cancer genome atlas (TCGA) and explored the potential association of LRP2 mutations with immunotherapy. Characteristics of LRP2 mutations in 33 cancer types were analyzed using large-scale public data. The association of LRP2 mutations with immune cell infiltration and immunotherapy efficacy was evaluated. Finally, a LPR2 mutation signature (LMS) was developed and validated by TCGA-UCEC and pan-cancer cohorts. Furthermore, we demonstrated the predictive power of LMS score in independent immunotherapy cohorts by performing a meta-analysis.

Results
Our results revealed that patients with LRP2 mutant had higher TMB and MSI compared with patients without LRP2 mutations. LRP2 mutations were associated with high levels of immune cells infiltration, immune-related genes expression and enrichment of immune related signaling pathways. Importantly, LRP2-mutated patients had a long overall survival (OS) after immunotherapy. In the endometrial cancer (EC) cohort, we found that patients with LRP2 mutations belonged to the POLE and MSI-H type and had a better prognosis. Finally, we developed a LRP2 mutations signature (LMS), that was significantly associated with prognosis in patients receiving immunotherapy.

Conclusion
These results indicated that LRP2 mutations can serve as a biomarker for personalized tumor immunotherapy. Importantly, LMS is a potential predictor of patients’ prognosis after immunotherapy.
Application
Authors: Degen Bernd 
Published: July 2022

AbstractData on genetic diversity and differentiation, as well as kinship between individuals, are important for the conservation of animal and plant genetic resources. Often genetic assignment is part of law enforcement of protected endangered species. The software GDA-NT 2021 is a new, freely available user-friendly Windows program that can be used to compute various measures of genetic diversity and population genetic differentiation. It further allows genetic assignment of individuals to populations and enables the calculation of kinship-coefficients and genetic distances among pairs of individuals within populations. GDA-NT 2021 specifically computes the alternative measures for population differentiation Dj and the standardized FST of Hedrick. It has more options to compute exclusion-probabilities in assignment tests, enables self-assignment tests for variable groups of individuals, and allows for information on geographic positions to be accounted for while using permutation tests to assess statistical significance.