bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nomogram to Predict Overall and Cancer-Specific Survival in Patients with Primary Bone Diffuse Large B-Cell Lymphoma: A Population-Based Study
Authors: Yang Xing-yao , He Xin , Zhao Yun 
Published: February 2022

Abstract
Background: Primary bone diffuse large B-cell lymphoma accounts for more than 80% of primary bone lymphoma, and as a rare disease, we created two nomogram to predict overall survival (OS) and cancer-specific survival (CSS) in patients with PD-DLBCL.Methods: 891 patients diagnosed with PB-DLBCL between 2007 and 2016 were extracted from the Surveillance, Epidemiology and End Results (SEER) database. Univariate and multivariate Cox analyses were performed to explore independent prognostic factors and to create two separate nomogram for OS and CSS. The area under the curve (AUC), calibration curve, decision curve analysis (DCA), and Kaplan-Meier curve analysis were used to evaluate the nomogram.Results: 4 variables were identified as independent prognostic factors for OS and 3 variables were identified as independent prognostic factors for CSS. the ROC curves demonstrated good discriminatory power of the nomogram. Calibration curves and DCA curves showed that nomogram had satisfactory ability to predict OS and CSS. k-M curves showed that age, gender, first location, chemotherapy, and tumor stage affected patient survival.Conclusions: Age, race, primary site, and chemotherapy are variables that affect OS. And age, race, and chemotherapy are variables that affect CSS in patients with PD-DLBCL. Two nomogram were created based on the above variables to provide more accurate individual survival prediction for PD-DLBCL patients and to help physicians make appropriate clinical decisions.
Clinical Impact of Remnant Lymphatic Invasion on The Recurrence of Esophageal Squamous Cell Carcinoma After Esophagectomy with Neoadjuvant Chemotherapy: A Retrospective Study
Authors: Okuda Sho , Ohuchida Kenoki , Shindo Koji , Moriyama Taiki , Kawata Jun , Tamura Koji , Sada Masafumi , Nagayoshi Kinuko , Mizuuchi Yusuke , Ikenaga Naoki , Nakata Kohei , Oda Yoshinao , Nakamura Masafumi 
Published: February 2022

Abstract
Background: For stage II and III esophageal squamous cell carcinoma (ESCC), neoadjuvant chemotherapy (NAC) followed by esophagectomy is recommended in Japanese guidelines. However, recurrence of ESCC is common regardless of the NAC regimen and operation method, and the effect of NAC on recurrence is limited.Methods: We retrospectively analyzed the outcomes of 54 patients who underwent esophagectomy for ESCC after NAC from 2010 to 2017. We selected 53 patients with ESCC without NAC followed by esophagectomy from 2001 to 2017 for comparison.Results: Among patients who underwent NAC followed by surgery, lymphatic invasion (ly) (hazard ratio: 2.632; 95% CI: 1.04–6.68, p = 0.042) and microscopic residual tumor (R) (hazard ratio: 24.21, 95% CI: 1.92–305, p = 0.014) were independent factors significantly associated with 3-year recurrence-free survival in patients with esophagectomy after NAC in multivariate analysis. In patients without ly after NAC, the presence of lymph node metastasis in pathological diagnosis (pN) was not significantly related to recurrence (p = 0.2401). Recurrence was significantly related to ly (+) (p = 0.0024) in the group with pN after NAC. There were significantly fewer ly (+) patients in the NAC (+) group (p = 0.0332) than those in the NAC (-) group.Conclusion: The presence of ly was an independent risk factor for recurrence of ESCC after esophagectomy following NAC. pN was not a significant recurrence factor for cases with esophagectomy following NAC in multivariate analysis. Adjuvant treatment after surgery may be required in cases with remnant ly after NAC.
Phase 2 Trial of a Vaccine Made from Autologous Dendritic Cells and Lysates from Autologous Tumor-Initiating Cells (AV-GBM-1) in Newly Diagnosed Glioblastoma Patients
Authors: Bota Daniela Annenelie 
Published: February 2022

Abstract
Background
Vaccine immunotherapy may improve survival in glioblastoma (GBM). A multicenter phase II trial was designed to estimate: (1) the success rate of manufacturing the AV-GBM-1 vaccine, (2) adverse events (AE) associated with repeated injections, and (3) survival.
Methods
Fresh tumor tissue was collected during surgery for newly diagnosed GBM. Eligible patients enrolled before starting concurrent radiation therapy and temozolomide (RT/TMZ) with intent-to-treat (ITT) after recovery from RT/TMZ. AV-GBM-1 was made by incubating autologous dendritic cells (DC) with a lysate of irradiated autologous tumor-initiating cells (TIC). Eligible patients were 18–70 years of age, with a Karnofsky Performance Status (KPS) 70 or greater, and which had a successful TIC culture and a sufficient number of monocytes collected. Before subcutaneous (s.c.) injections, a cryopreserved dose was thawed and admixed with 500 mg of granulocyte-macrophage colony-stimulating factor.
Results
Success rates were 97% for both TIC production and monocyte collection. AV-GBM-1 was manufactured for 63/63 patients; 60 enrolled per ITT; 57 started AV-GBM-1. The most common AE attributed to AV-GBM-1 were local injection-site reactions (16%) and flu-like symptoms (10%). Treatment-emergent AE included seizures (33%), headache (37%), and focal neurologic symptoms (28%). One patient discontinued AV-GBM-1 because of seizures. Median progression-free survival (PFS) and overall survival (OS.) from ITT enrollment were 10.3 and 16.0 months, respectively. Median PFS from the first injection was 8.1 months.
Conclusions:
AV-GBM-1 was reliably manufactured. Treatment was well-tolerated, but there were numerous treatment-emergent central nervous system AE, probably primarily due to GBM and its treatment. OS was slightly increased, but median PFS was substantially longer than historical benchmarks.
Preoperative Inverse Albumin-to-Globulin Ratio Predicts Worse Oncologic Prognosis Following R0 Resection for Hilar Cholangiocarcinoma
Authors: Liu Zhi-Peng , Cheng Zheng-Jun , Dai Hai-Su , Chen Wei-Yue , Liu Xing-Chao , Fan Hai-Ning , Pan Yu , Bai Jie , Jiang Yan , Zhang Yan-Qi , Deng Shi-Quan , Chen Zhi-Yu 
Published: February 2022

Abstract
Background & Aims: Inverse albumin-to-globulin ratio (IAGR) is defined as an AGR in serum of less than 1, which commonly indicates poor protein synthesis and severe inflammation. This study aimed to evaluate whether preoperative IAGR is associated with worse oncologic survival after R0 resection for hilar cholangiocarcinoma (HCCA).Methods: Patients who underwent R0 resection for newly diagnosed HCCA from January 2011 to December 2018 were enrolled from a multicenter database. Based on their preoperative AGR levels, all patients were divided into the IAGR and NAGR groups. We compared their clinical characteristics and long-term oncologic prognosis. Univariate and multivariate Cox regression analyses were performed to identify risk factors for overall survival (OS) and recurrence-free survival (RFS). The time-dependent area under the curve (AUC) was compared to determine the predictive ability of AGR and other liver function indicators for long-term oncologic prognosis.Results: Overall, 323 patients with R0 resection of HCCA were included; 58 (18.0%) were in the IAGR group. The 5-year OS and RFS rates in the IAGR group were 6.3% and 2.5%, which were significantly worse than those in the NAGR group (24.5% and 21.2%, P < 0.05). Multivariate Cox regression analyses identified IAGR an independent risk factor for predicting worse OS (HR: 1.619, 95% CI: 1.161-2.258, P = 0.005) and RFS (HR: 1.773, 95% CI: 1.289-2.438, P < 0.001). The time-dependent AUCs of AGR for OS and RFS were superior to those of other liver function indicators.Conclusion: Preoperative IAGR is valuable for predicting worse OS and RFS in patients who underwent R0 resection for HCCA. AGR has ideal predictive ability for long-term oncological prognosis.
Risk Factors and Predictive Models for Early Cerebrospinal Fluid Leak after Anterior Surgery for Degenerative Cervical Myelopathy
Authors: Heng Wei , Wang Mingqi , Wei Feilong , Du Mingrui , Zhu Kailong , Gao Haoran , Qian Jixian , Zhou Chengpei 
Published: February 2022

Abstract
OBJECTIVE To investigate the incidence of and risk factors for early cerebrospinal fluid (CSF) leak after anterior surgery for degenerative cervical myelopathy (DCM) and construct risk predictive models.METHODS Patients diagnosed with DCM and treated with anterior surgery from January 2007 to August 2018 were retrospectively selected. The basic data of preoperative and intraoperative records were extracted. Subsequently, we analyzed the relationship between early postoperative CSF leak and variables by performing restrictive cubic splines (RCS) for continuous variables and univariate and multivariate logistic regression for possible variables. The selected independent variables and covariates were modeled based on the Akaike information criterion (AIC). We generated receiver operating characteristic (ROC) curves and calibration curves to evaluate the nomogram. RESULTS Seventeen patients had CSF leak, with an incidence of 3.66%. There was a linear relationship between CSF leak and age (P=0.003) as well as bleeding loss (P<0.001). Variables were selected by logistic regression analysis, including age (per SD) (OR=2.04, P=0.004), revision surgery (OR=1.13, P=0.032), ossification of the posterior longitudinal ligament (OPLL) (OR=4.07, P=0.027), and blood loss (per SD) (OR=1.75, P=0.002). The predictive model included age (per SD), sex, revision surgery, OPLL, and blood loss (per SD), with c-statistic=0.821. CONCLUSIONS Older age, revision surgery, OPLL and more intraoperative blood loss were independent risk factors for early postoperative CSF leak. The predictive model can be used to guide the prevention of CSF leak in DCM patients.
Translation, Cultural Adaptation and Validation of the Urdu Version of Ronald Morris Low Back Pain and Disability Questionnaire in Pakistani Population
Authors: Sohail Maria , Ahmad Ashfaq , Arslan Syed Asadullah , Munawar Arooj , Amjad Fareeha , Asjad Ayesha 
Published: February 2022

Abstract
Background: The most common cause of disability is low back pain and it is common in every population especially in older generation. Low back pain is not a disease but a symptom instead. A most prevalent type of low back pain is non-specific low back ache. Low back pain is causing functional disabilities in both of the populations belong to developed and under developed countries. It is on sixth number in terms of overall disease burden.Methodology: According to the pre-defined guidelines the translation and cultural adaptation was performed in the study. A total of 150 participants were recruited (86 men and 64 women). There were two stages to the research: 1) Translation and cultural adaptation 2) Testing for reliability and validity The final Urdu version of the RMDQ was tested for reliability (test-retest and internal consistency at 95% confidence interval) and validity (Convergent validity).Results: The Urdu-RMDQ demonstrated very good test-retest reliability (ICC= 0.846 (0.808-0.880); CI=95 percent). Cronbach's alpha was 0.860, indicating that RMQ has very good internal consistency. The item total correlation value is 0.23, confirming that the Urdu version of the RMQ is internally consistent. Pearson's correlation coefficient was used to assess convergence validity. The study found strong correlation between RMDQ and Visual analogue scale that means RMDQ has strong convergent validity.Conclusion: RMDQ Urdu is reliable and valid instrument to measure low back pain and disability in Pakistani population with excellent psychometric properties.
Human Adipose-Derived Stem Cells Delay Muscular Atrophy After Peripheral Nerve Injury in Rats
Authors: Qu Siwei , Ma Ning , Wang Weixin , Chen Sen , Wu Qi , Li Yangqun , Yang Zhe 
Published: February 2022

Abstract
Introduction: Muscle is often accompanied by denervation atrophy after peripheral nerve injury. Human adipose-derived stem cells (hADSCs) and platelet-rich plasma injections into a muscle after peripheral nerve injury were examined.Methods: The rats were randomly divided into 5 groups. First group rats’ sciatic nerve was exposed with untreated, others groups rats’ sciatic nerve injury model was created first. PBS, hADSCs, PRP, and a mixture of hADSCs and PRP were injected into the gastrocnemius immediately postoperatively. Quantitation of gross musculature and muscle fiber area, SFI were investigated.Results: In 4 weeks post-surgery, post hoc Bonferroni tests showed significant differences in wet weight ratios when the hADSC group, the PRP group, and the combine group were compared with the PBS group. Areas of muscle fiber were larger in the hADSC group and the combine group compared with the PBS group at 4 weeks post-surgery.Discussion: hADSCs injection may delay muscular atrophy after sciatic nerve injury in rats, and PRP injection has little effect on delayed muscular atrophy.
Identification of immune-related lncRNA Pairs and construction and validation of a new prognostic signature of colon cancer
Authors: Xie Hui , Xu Minxian , Li Qing , Zhang Jianfang 
Published: February 2022

Abstract
Background: More and more evidences show that immune-related long non-coding ribonucleic acid (irlncRNAs) is a potential prognostic factor for colon cancer. The relevant gene pair pattern can improve the sensitivity of the prognostic model. Therefor, our present study aimed to identify irlncRNA Pairs and construct and validate a new prognostic signature in colon cancer.Methods:We downloaded the expression matrix of mRNA and lncRNA of patients with colon cancer and their clinical information from the public TCGA database. We obtained immune genes from the ImmPort database. Co-expression analysis was performed to identify irlncRNAs. We built an irlncRNA pair matrix by comparing the expression levels of each lncRNA pair in a cycle. Univariate Cox regression analysis, LASSO penalized regression analysis and multivariate Cox regression analysis were performed to determine the final variables to construct the prognostic risk score model (a new signature). We darw the receiver operating characteristic (ROC) curves of the signature and clinical characteristics, and determined the optimal cutoff value by the optimal Akaike Information Criterion (AIC) value. Based on the optimal cutoff value of the ROC curve of the signature, colon cancer patients were divided into the high- and low-risk groups. Then, the signature was evaluated by clinicopathological features, tumor infiltrating immune cells, checkpoint-related biomarkers, targeted therapy, and chemotherapy.Results:We identified 8 lncRNA pairs including AC103740.1|LEF1−AS1, LINC02391|AC053503.5, WWC2−AS2|AL355916.2, AC104090.1|NEURL1−AS1, AC099524.1|AL161908.1, AC074011.1|AL078601.2, AL355916.2|LINC01723 and AP003392.4|LINC00598 from 71 differently expressed irlncRNAs. We constructed a prognostic risk score model (a new signature) using these optimal 8 irlncRNA pairs. ROC curve analysis revealed that the highest AUC value of the signature was 0.776 at 1 year, with the the optimal cutoff value of 1.283. Our present study also showed that the constructed signature could accurately identify adverse survival outcomes, prognostic clinicopathological features, and specify tumor invasion status. The expression of immune checkpoint-related genes and chemical drug sensitivity were related to different risk groups.Conclusion: In our present study, we constructed a new irlncRNA signature of colon cancer based on the irlncRNA pairs instead of the special expression level of lncRNA. We found this signature not only had good prognostic value, but also had certain clinical value, which might provide a new sight for the treatment and prognosis of colon cancer.
Association of Perceived Life Satisfaction with Attitudes toward Life-Sustaining Treatment Among the Elderly in South Korea
Authors: Yun Il , Kim Hyunkyu , Park Eun-Cheol , Jang Suk-Yong 
Published: February 2022

Abstract
Background
Amidst rapid population aging, South Korea enacted the Well-dying Act, late among advanced countries, but public opinion on the act is not still clear. Against this background, this study aims to: 1) investigate factors affecting elderly individuals’ attitude toward life-sustaining treatment, and 2) examine whether attitude toward life-sustaining treatment is related to their perceived life satisfaction.
Methods
Data from the 2020 Survey of Living Conditions and Welfare Needs of Korean Older Persons were used. There were 9,916 participants (3,971 males; 5,945 females). We used multivariable-adjusted Poisson regression models with robust variance to examine the association between perceived life satisfaction and attitude toward life-sustaining treatment and calculate prevalence ratios (PR) and 95% confidence intervals (CI).
Results
After adjusting potential confounders, the probabilities that the elderly who were dissatisfied with their current life would favor life-sustaining treatment were 1.52 times (95% CI: 1.15–1.64) and 1.28 times (95% CI: 1.09–1.51) higher for men and women, respectively, than the elderly who were satisfied. In addition, attitudes in favor of life-sustaining treatment were observed prominently among the elderly with long schooling years or high household income, when they were dissatisfied with their life.
Conclusions
Our results suggested that for the elderly, life satisfaction is an important factor influencing how they exercise their autonomy and rights regarding dying well and receiving life-sustaining treatment. It is necessary to introduce interventions that would enhance the life satisfaction of the elderly and terminally ill patients and enable them to make their own decisions according to the values of life.
Instantaneous synthesis of organic-inorganic laccase-cobalt phosphate hybrid nanoflowers: Structural and biocatalytic characterization
Authors: Vojdanitalab Khashayar , Jafari-Nodoushan Hossein , Mojtabavi Somayeh , Shokri Mahtab , Jahandar Hoda , Faramarzi Mohammad Ali 
Published: February 2022

Abstract
Organic-inorganic hybrid nanoflowers (HNFs) have been synthesized by soft biomineralization procedures and are mainly used in biocatalysis and biosensing. Previously-reported methods for the synthesis of HNFs have so far required a 3-day incubation, bath sonication, or shear stress tension, which possibly introduces damage to the organic component. In this study, a novel method for instant fabrication of laccase@Co3(PO4)2•HNFs was developed without using harsh conditions. The prepared HNFs were assembled instantly by the “concentrated method,” which resulted in the fast growth of the flower-shaped nanostructures by a higher collision rate of the primary nucleation sites. The obtained results indicated that catalytic efficiency and enzymatic activity of laccase@Co3(PO4)2•HNFs were 113% and 110%, respectively, compared to the free enzyme. Also, the stability of the immobilized enzyme was enhanced by 400% in basic pH values. The activity of laccase@Co3(PO4)2•HNFs declined to 50% of the initial value after 10 reusability cycles, indicating successful immobilization of the enzyme. Structural studies revealed a 32% increase in the α-helix content after hybridization with cobalt phosphate, which improved the activity and stability of the immobilized laccase. Furthermore, the fabricated HNFs exhibited a considerable ability to remove moxifloxacin as an emerging pollutant. The antibiotic (10 mg/L) was removed by 24% and 75% after 24 h through adsorption and biodegradation mechanisms, respectively. This study introduces a new method for synthesizing HNFs, which could be used for the instant fabrication of efficient biocatalysts, biosensors, and adsorbents to be potentially employed in industrial, biomedical, and environmental applications.
Compare HBV relapse rates in patients who discontinue tenofovir disoproxil fumarate or tenofovir alafenamide fumarate
Authors: Chen CH , Jeng Wen-Juei , Hu Tsung-Hui , Liu Yen-Chun , Wang Jing-Houng , Hung Chao-Hung , Lu Sheng-Nan , Chien Rong-Nan 
Published: February 2022

Abstract
Background/purpose: Clinical relapse occurred majorly within the first six months after stopping tenofovir disoproxil fumarate (TDF) in hepatitis B e antigen (HBeAg)-negative chronic hepatitis B (CHB) patients. However, the incidence and relapse pattern in patients stopping Tenofovir alafenamide fumarate (TAF), a prodrug of tenofovir which more concentrated in hepatocyte, is unknown. Methods: HBeAg-negative CHB patients stopping TDF (off-TDF) or switch to TAF more than 3 months (off-TAF) before discontinuation from two medical centers were recruited. The propensity score-matching method (PSM) was used by creating a ratio of 1:3 between the off-TAF group versus the off-TDF group to adjust age, sex, HBV genotype, cirrhosis, HBV DNA at entry, treatment and consolidation duration and end-of-treatment (EOT) HBsAg.Results: After PSM, 60 off-TAF and 180 off-TDF patients were analyzed. In off-TDF group, the cumulative rates of virological and clinical relapse at 52 weeks were 75.4% and 57.4%, respectively, and were 90.8% and 63.6% in off-TAF group, respectively. Patients in off-TAF group had significantly higher virological relapse rates than those in off-TAF group (p = 0.031), but not clinical relapse (p = 0.418). Multivariate cox regression analysis showed that off-TAF group was an independent factor of virological relapse, but not clinical relapse. Retreatment rate and severity of clinical relapse and hepatic decompensation rate were comparable between off-TDF and off-TAF groupsConclusions: Off-TDF group had a higher virological relapse rate than off-TAF group in HBeAg-negative CHB patients. However, the difference of clinical relapse pattern and severity was not clinically important between two groups.
Socioeconomic Factors and Use of Psychotherapy in Common Mental Disorders Predisposing to Disability Pension
Authors: Leppänen Helena , Kampman Olli , Autio Reija , Karolaakso Tino , Näppilä Turkka , Rissanen Päivi , Pirkola Sami 
Published: February 2022

Abstract
Background
Research in high-income countries has identified low socioeconomic status as a risk factor for disability pension (DP) due to common mental disorders (CMDs). Psychotherapy is an evidence-based treatment for the majority of CMDs along with medication and it is often targeted to prevent work disability. This study examines socioeconomic differences in the use of rehabilitative psychotherapy in Finland, where citizens have universal health coverage, but psychotherapy is partly dependent on personal finance.
Methods
The study subjects (N = 22,501) were all the Finnish citizens granted a DP due to CMD between 2010 and 2015 and a comparison group (N = 57,732) matched based on age, gender, and hospital district. Socioeconomic differences in psychotherapy use were studied using logistic regression models. Socioeconomic status was defined by education, income, and occupation. Age, gender, and family status were also examined.
Results
A lower level of education, lower occupational status (blue-collar worker), male gender, and older age, were associated with less frequent psychotherapy use, in both groups. Education was the strongest component of socioeconomic status associated with psychotherapy use, but the role of income was not straightforward. Unemployment when approaching DP, but not otherwise, was a risk factor for not receiving rehabilitative psychotherapy. Socioeconomic disparities were not any smaller among CMD patients approaching DP than in the comparison group.
Conclusion
This study demonstrates the disparity in the provision of psychotherapy for CMD patients, even on the verge of DP with an acute need for services. This disparity is partly related to a complex interplay of socioeconomic factors and the service system characteristics. Factors predisposing to unequal access to mental health services are presumably diverse and should be studied further.