bluuebunny/crossref_metadata_2025_split huggingface dataset:
Global Trends of Stem Cell Precision Medicine Research (2018–2022): A Bibliometric Analysis
Authors: Liu Muge , Yang Fan , Xu Yingbin 
Published: June 2022

BackgroundStem cells are a group of cells that can self-renew and have multiple differentiation capabilities. Shinya Yamanaka first discovered a method to convert somatic cells into pluripotent stem cells in 2006. Stem cell therapy can be summarized into three aspects (regenerative treatment, therapy targeted at stem cells, and establishment of disease models). Disease models are mainly established by induced pluripotent stem cells, and the research of stem cell precision medicine has been promising in recent years. Based on the construction of 3D, patient-specific disease models from pluripotent induced stem cells, proper research on disease development and treatment prognosis can be realized. Bibliometric analysis is an efficient way to quickly understand global trends and hotspots in this field.MethodsA literature search of stem cell precision medicine research from 2018 to 2022 was carried out using the Web of Science Core Collection.VOSviewer, R-bibliometrix, and CiteSpace software programs were employed to perform the bibliometric analysis.ResultsA total of 552 publications were retrieved from 2018 to 2022. Annual publication outputs trended upward and reached a peak of 172 in 2021. The United States contributed the most publications (160, 29.0%) to the field, followed by China (63, 11.4%) and Italy (60, 10.9%). International academic collaborations were active. CANCERS was considered the most productive journal with 18 documents. NATURE was the most co-cited journal with 1860 times citations. The most cited document was entitled “Induced Pluripotent Stem Cells for Cardiovascular Disease Modeling and Precision Medicine: A Scientific Statement From the American Heart Association” with 9 times local citations. “ precision medicine” (n = 89, 12.64%), “personalized medicine” (n = 72, 10.23%), “stem cells” (n = 43, 4.40%), and “induced pluripotent stem cells” (n = 41, 5.82%), “cancer stem cells” (n = 31, 4%), “organoids” (n = 26, 3.69%) were the top 6 frequent keywords.ConclusionThe present study performs a comprehensive investigation concerning stem cell precision medicine (2018–2022) for the first time. This research field is developing, and a deeper exploration of 3D patient-specific organoid disease models is worth more research in the future.
Radiotherapy of Breast Cancer—Professional Guideline 1st Central-Eastern European Professional Consensus Statement on Breast Cancer
Authors: Polgár Csaba , Kahán Zsuzsanna , Ivanov Olivera , Chorváth Martin , Ligačová Andrea , Csejtei András , Gábor Gabriella , Landherr László , Mangel László , Mayer Árpád , Fodor János 
Published: June 2022

The international radiotherapy (RT) expert panel has revised and updated the RT guidelines that were accepted in 2020 at the 4th Hungarian Breast Cancer Consensus Conference, based on new scientific evidence. Radiotherapy after breast-conserving surgery (BCS) is indicated in ductal carcinoma in situ (stage 0), as RT decreases the risk of local recurrence (LR) by 50–60%. In early stage (stage I-II) invasive breast cancer RT remains a standard treatment following BCS. However, in elderly (≥70 years) patients with stage I, hormone receptor-positive tumour, hormonal therapy without RT can be considered. Hypofractionated whole breast irradiation (WBI) and for selected cases accelerated partial breast irradiation are validated treatment alternatives to conventional WBI administered for 5 weeks. Following mastectomy, RT significantly decreases the risk of LR and improves overall survival of patients who have 1 to 3 or ≥4 positive axillary lymph nodes. In selected cases of patients with 1 to 2 positive sentinel lymph nodes axillary dissection can be substituted with axillary RT. After neoadjuvant systemic treatment (NST) followed by BCS, WBI is mandatory, while after NST followed by mastectomy, locoregional RT should be given in cases of initial stage III–IV and ypN1 axillary status.
A New Approach to Estimate the Fatigue Limit of Steels Based on Conventional and Cyclic Indentation Testing
Authors: Görzen David , Ostermayer Pascal , Lehner Patrick , Blinn Bastian , Eifler Dietmar , Beck Tilmann 
Published: June 2022

For a reliable design of structural components, valid information about the fatigue strength of the material used is a prerequisite. As the determination of the fatigue properties, and especially the fatigue limit σw, requires a high experimental effort, efficient approaches to estimate the fatigue strength are of great interest. Available estimation approaches using monotonic properties, e.g., Vickers hardness (HV), and in some cases the cyclic yield strength, only allow a rough estimation of σw. The approaches solely based on monotonic properties lead to substantial deviations of the estimated σw in relation to the experimentally determined fatigue limit as they do not consider the cyclic deformation behavior. In this work, an estimation approach was developed, which is based on a correlation analysis of the fatigue limit σw, HV, and the cyclic hardening potential obtained in instrumented cyclic indentation tests (CIT). For this, eleven conditions from five different low-alloy steels were investigated. The CIT enable an efficient and quantitative determination of the cyclic hardening potential, i.e., the cyclic hardening exponentCHT eII, and thus, the consideration of the cyclic deformation behavior in an estimation approach. In this work, a strong correlation of σw with the product of HV and |eII| was observed. In relation to an existing estimation approach based solely on HV, considering the combination of HV and |eII| enables the estimation of σw with an enormously increased precision.
Critical Role of Osteopontin in Maintaining Urinary Phosphate Solubility in CKD
Authors: Stubbs Jason R. , Zhang Shiqin , Jansson Kyle P. , Fields Timothy A. , Boulanger Joseph , Liu Shiguang , Rowe Peter S. 
Published: June 2022

Key Points

Osteopontin (OPN) is highly expressed by tubular epithelial cells in CKD and functions to maintain calcium-phosphate solubility in tubular fluid.Reduced functional nephrons alone, in the absence of kidney injury, is sufficient to stimulate OPN expression by tubular epithelial cells.High levels of tubular fluid phosphate or the presence of phosphate-based crystals may stimulate tubular OPN production in CKD.

Background
Nephron loss dramatically increases tubular phosphate to concentrations that exceed supersaturation. Osteopontin (OPN) is a matricellular protein that enhances mineral solubility in solution; however, the role of OPN in maintaining urinary phosphate solubility in CKD remains undefined.

Methods
Here, we examined (1) the expression patterns and timing of kidney/urine OPN changes in CKD mice, (2) if tubular injury is necessary for kidney OPN expression in CKD, (3) how OPN deletion alters kidney mineral deposition in CKD mice, (4) how neutralization of the mineral-binding (ASARM) motif of OPN alters kidney mineral deposition in phosphaturic mice, and (5) the in vitro effect of phosphate-based nanocrystals on tubular epithelial cell OPN expression.

Results
Tubular OPN expression was dramatically increased in all studied CKD murine models. Kidney OPN gene expression and urinary OPN/Cr ratios increased before changes in traditional biochemical markers of kidney function. Moreover, a reduction of nephron numbers alone (by unilateral nephrectomy) was sufficient to induce OPN expression in residual nephrons and induction of CKD in OPN-null mice fed excess phosphate resulted in severe nephrocalcinosis. Neutralization of the ASARM motif of OPN in phosphaturic mice resulted in severe nephrocalcinosis that mimicked OPN-null CKD mice. Lastly, in vitro experiments revealed calcium-phosphate nanocrystals to induce OPN expression by tubular epithelial cells directly.

Conclusions
Kidney OPN expression increases in early CKD and serves a critical role in maintaining tubular mineral solubility when tubular phosphate concentrations are exceedingly high, as in late-stage CKD. Calcium-phosphate nanocrystals may be a proximal stimulus for tubular OPN production.
PERANCANGAN SISTEM INFORMASI EKSPEDISI RAWAT JALAN DI RUMAH SAKIT SARININGSIH
Authors: Nisa Nida Khoerun , Azzahra Nadhifa Trirani , Hidayati Meira , Abdussalaam Falaah 
Published: June 2022

TheBook Expedition is a book that contains patient data, used for proof of handoverfiles medical record offrom the medical record unit to the polyclinic, to support the needs of outpatient services. At Sariningsih Hospital the recording of expedition books still uses manual recording assisted by Microsoft Excel, thus making delays provision of medical record files and delays in returning medical record files. For this reason, an Outpatient Expedition system is made, so that the process of returning medical record files is more regular and outpatient services at the hospital are more effective. For this reason, themethod waterfall and UML (Unfield Modeling Language) are used.The result of this research is an outpatient expedition system. Of course it can provide convenience to medical record officers.

Keywords: Information System, Medical Record Expedition, Xampp, Sublime, Diagram UML.
KAILAN (Brassica oleraceae var acephala) GROWTH AND YIELD AT CONCENTRATIONS OF PLANT GROWTH PROMOTING RHIZOBACTERIA (PGPR) AND OTHER PLANTING MEDIA ONE OF THE TEHNIC EMPOWERMENT FARMERS
Authors: Hadi Pramono hadi , Rahayu Tri , Al Fatonah Fatma 
Published: June 2022

ABSTRACK
The study was titled Kailan (Brassica oleraceae var acephala) Growth And Yield at Concentration of Plant Growth Promotion Rhizobacteria (PGPR) And Other Planting Media One of The Tehnic Empowerment Farmers. It has been held in November 2019 until January 2020 in Kondo Hamlet, Balong Village, Jenawi District, Karanganyar Regency. This study uses a Complete Randomized Design (RAL) method consisting of 2 treatment factors first is a kind of planted media (M) consists of 3 kinds, namely: soil media, straw compost and goat manure (M1), soil media straw compost and cow manure (M2), soil media, straw compost and chicken manure (M3) . The second factor is the concentration of PGPR (K) consisting of 3 treatment concentrations of PGPR 0 ml / l water (K0), PGPR concentration of 15 ml / l of water (K1), concentration of PGPR 30m l / l of water (K2).
The results showed that the variety of planting media has a very different effect on the number of leaves, the weight of wet clusters, and has a real effect on the weight of consumption and volume of leaves and has no real effect on the height of plants. PGPR concentration treatment is very influential on leaf volume, has a real effect on leaf count, consumption weight, high plant, but has no noticeable effect on wet trapping weight. Interaction of various planting media and PGPR concentration shows no noticeable effect on the number of leaves per plant, consumption weight, wet weight, height of plants and leaf volume.
The variety of planted media and PGPR concentration to the growth and yield of kailan plants is shown in the parameters of heavy wet weight consumption weight (46.97 g) obtained in the combination of treatment M2K1 (mixed media soil, straw compost and manure cattle, with a concentration of PGPR 15 ml / l water). The weight of the slimmest consumption (21.15 g), obtained in the combination of M1K0 treatment (mixed media of soil, straw compost and goat manure, with a PGPR concentration of 0 ml / litre of water).

Keywords: Kailan, planting media, PGPR.
A Survey of Security Mechanisms for Edge Computing based Connected Autonomous Vehicles
Authors: Gupta Sandeep , Maple Carsten 
Published: June 2022

<p>Edge Computing-based Connected Autonomous Vehicles (EC-CAVs) can fulfill the emerging demand for smart transportation on a global scale. Such innovations to transportation ecosystems can bring manyfold benefits from fully autonomous driving services to proactive vehicle monitoring and traffic management. Given the complexity involved in the deployment of EC-CAVs, zero-tolerance safety and security measures must be incorporated to avert vehicle immobilization, road accidents, disclosure of sensitive data, or any potential threats. This paper presents a reference architecture of EC-CAVs to investigate existing and emerging cyber-threats for deriving a common attack taxonomy for the EC-CAVs ecosystem. Subsequently, a comprehensive survey of security mechanisms is presented that can ensure safe and secure transportation of passengers from one destination to another using an EC-CAVs ecosystem.</p>
Determinants of Adolescent Sexual Behavior in Cirebon Regency
Authors: Ashari Ayu , Ria Yulianti Triwahyuningsih  , Fika Nurul Hidayah  
Published: June 2022

Introduction: This study aims to determine what factors are associated with adolescent sexual behavior in the district.
Methods: This study uses analytical methods. The type of research used is quantitative research with a cross-sectional approach, statistical tests, and data processing using Partial Least Square (SmartPLS 3.0).
Results: The results of the study show that (1) Information media has a significant influence on knowledge; (2) Information media and the role of parents have a significant influence on the dating status of adolescents; (3) Information media, peer influence, knowledge, and demographic status have a significant influence on adolescent attitudes; (4) The influence of peers, demographic status, and courtship status have a significant influence on adolescent sexual behavior; (5) 10.88% of sexual behavior is influenced by factors in this study, while 89.12% of sexual behavior is influenced by other factors outside this study.
Conclusion: Information media has a significant influence on knowledge. The influence of peers, demographic status, and dating status has a significant influence on adolescent sexual behavior.
PERAN IBU SEBAGAI PENDAMPING ANAK DALAM PEMBELAJARAN ONLINE SAAT PANDEMI COVID-19 DI KABUPATEN SIDOARJO
Authors: Rodiyah Isnaini , Puspitasari Monicha 
Published: June 2022

Ibu merupakan madrasah pertama bagi anak dalam keluarga, sehingga ibu memiliki peran yang sangat penting bagi keberhasilan pendidikan anak. Selain mendidik anak, di jaman yang sudah modern saat ini ibu dapat menjalankan peran ganda. Seorang ibu juga dapat mengambil peran sebagai pekerja untuk menunjang perekonomian keluarga ataupun sebagai sarana aktualisasi diri. Kondisi pandemi covid-19 membuat ibu harus berpikir lebih keras, satu sisi dihadapkan dengan tantangan ekonomi akibat pandemi covid, di sisi lain ibu juga dituntut mampu membimbing anak dalam pembelajaran daring. Penelitian ini bertujuan untuk menganalisis dan mendeskripsikan peran ibu sebagai pendamping anak dalam pembelajaran daring selama pandemi covid-19 di Kabupaten Sidoarjo. Penelitian ini merupakan penelitian deskriptif kualitatif dengan menggunakan teknik purposive sampling dalam menentukan informan. Teknik pengumpulan data dilakukan dengan wawancara, observasi, dan dokumentasi. Teknik analisis data menggunakan model analisis interaktif yang dikemukakan oleh Miles dan Huberman, terdiri dari empat komponen yaitu pengumpulan data, reduksi data, penyajian data, dan penarikan kesimpulan. Hasil penelitian menunjukkan bahwa peran ibu sebagai pendamping anak dalam pembelajaran daring selama pandemi covid-19 di Kabupaten Sidoarjo yaitu mendidik dengan cara mengingatkan jadwal pembelajaran daring dan meluangkan waktu untuk belajar agar mampu menjelaskan materi yang tidak dipahami anak. Membimbing dengan cara memberikan arahan dan bantuan ketika anak mengalami kesulitan belajar. Sebagai fasilitator dengan memberikan fasilitas smartphone dan koneksi internet untuk mendukung pembelajaran daring. Selain itu juga menjadi motivator dalam meningkatkan semangat belajar anak ketika merasa bosan. Namun beberapa ibu tidak menjalankan peran secara maksimal dalam mendampingi belajar anak karena tidak dapat membagi waktu di tengah kesibukan pekerjaan.
Kata Kunci : peran ibu, kebijakan pendidikan masa pandemi, pembelajaran daring
PERAN PEREMPUAN DALAM MENINGKATKAN EKONOMI KELUARGA DI MASA PANDEMI COVID-19
Authors: Made Anom Yuliati I Gusti Ayu , Sri Widnyani Ida Ayu Putu 
Published: June 2022

Currently our country is being hit by the Covid-19 pandemic which has spread very quickly, making women return to their highest level of awareness to always fight to save their family and nation. This study aims to describe and analyze the important role that women can play in the economic resilience of the family to deal with situations and conditions affected by Covid 19. The research carried out is using a qualitative approach. Because this research uses literature study or literature study. The results show that the important role that women can play in family economic resilience in the face of the COVID-19 pandemic is as an additional breadwinner in the family economy, managing finances in the household, the new role of mothers in the new normal era such as teaching healthy living behavior, being a personal teacher for their children, doing farming activities in the yard of the house. And also the results of the study show that family support is very influential on working mothers during the COVID-19 pandemic.
Key words: empowerment, woman, economic resilience, family
Bilateral Triquetrum Fracture with Specific Radiographic Signs
Authors: ADEMOĞLU Enis , ÖZDEMİR Serdar , EROĞLU Serkan Emre 
Published: June 2022

A 44-year-old male patient presented to the emergency department with pain in both wrists because of falling. It was learned that both wrists of the patient were in dorsiflexion while falling, and there was no additional injury. The Glasgow coma scale score was 15; vital values were within normal limits. The patient had bilateral wrist tenderness, pain with ulnar deviation, and edema on the dorsal side. In addition, he had pain with palpation of the left snuff box. Examinations of the ulnar and radial nerves and arteries were normal. X-rays showed a triquetrum fracture in the right hand, and a triquetrum and scaphoid fracture in the left hand. While triquetrum fractures were not apparent on anterior-posterior radiographs, they were clearly visible on both lateral radiographs (Figure 1). With a short-arm splint for the right hand and a scaphoid cast for the left hand, the patient recovered without sequelae after 6 weeks of wrist immobilization.
Triquetrum fractures are generally classified as dorsal cortex fractures and body fractures. Dorsal cortex fractures are more common and are usually seen as avulsion fractures. They occur with trauma, especially in the form of falling with wrist dorsiflexion. Our patient also fell with the same mechanism. To diagnose triquetrum fractures, lateral and oblique radiographs should be performed in addition to anterior-posterior radiographs. In particular, dorsal cortex fractures may not be visible on the anteroposterior radiograph, while the avulsion fragment is better seen on the lateral radiograph. The appearance of triquetral fractures on the lateral radiograph is called the "pooping duck sign" because of the typical shape it forms with the scaphoid and lunate bone (Figure 2). In our case, although both triquetrum fractures could not be clearly seen on the anterior-posterior radiograph, they were seen more clearly with typical findings on the lateral radiograph. Triquetrum fractures are typical of carpal bone fractures, which can be seen more prominently on lateral radiographs, and knowing the specific finding on the lateral radiograph may help with the diagnosis.
Searching for Anomalies in the ZTF Catalog of Periodic Variable Stars
Authors: Chan Ho-Sang , Villar V. Ashley , Cheung Siu-Hei , Ho Shirley , O’Grady Anna J. G. , Drout Maria R. , Renzo Mathieu 
Published: June 2022

Abstract
Periodic variables illuminate the physical processes of stars throughout their lifetime. Wide-field surveys continue to increase our discovery rates of periodic variable stars. Automated approaches are essential to identify interesting periodic variable stars for multiwavelength and spectroscopic follow-up. Here we present a novel unsupervised machine-learning approach to hunt for anomalous periodic variables using phase-folded light curves presented in the Zwicky Transient Facility Catalogue of Periodic Variable Stars by Chen et al. We use a convolutional variational autoencoder to learn a low-dimensional latent representation, and we search for anomalies within this latent dimension via an isolation forest. We identify anomalies with irregular variability. Most of the top anomalies are likely highly variable red giants or asymptotic giant branch stars concentrated in the Milky Way galactic disk; a fraction of the identified anomalies are more consistent with young stellar objects. Detailed spectroscopic follow-up observations are encouraged to reveal the nature of these anomalies.
A Comparison of Chemical Models of Exoplanet Atmospheres Enabled by TauREx 3.1
Authors: Al-Refaie A. F. , Changeat Q. , Venot O. , Waldmann I. P. , Tinetti G. 
Published: June 2022

Abstract
Thermochemical equilibrium is one of the most commonly used assumptions in current exoplanet retrievals. As science operations with the James Webb Space Telescope (JWST) draw near and with the planned launch of Ariel, it is crucial to assess the underlying biases and assumptions made when applying self-consistent chemistry to spectral retrievals. Here we use the flexibility of TauREx 3.1 to cross-compare three state-of-the-art chemical equilibrium codes: ACE, FastChem, and GGchem. We simulate JWST spectra for ACE, FastChem, GGchem, and GGchem+condensation containing only the elements C, H, O, and N and spectra for FastChem, GGchem, and GGchem+condensation with a more extensive range of elements, giving seven simulated JWST spectra in total, and then cross-retrieve, giving a total of 56 retrievals. Our analysis demonstrates that, like-for-like, all chemical codes retrieve the correct parameters to within 1% of the truth. However, in retrievals, where the contained elements do not match the truth, parameters such as metallicity deviate by 20% while maintaining extremely low uncertainties <1%, giving false confidence. This point is of major importance for future analyses on JWST and Ariel, highlighting that self-consistent chemical schemes that do not employ the proper assumptions (missing species, fixed elemental ratios, condensation) are at risk of confidently biasing interpretations. Free chemistry retrievals employing parametric descriptions of the chemical profiles can provide alternative unbiased explorations.
Cloudlet Capture Model for Asymmetric Molecular Emission Lines Observed in TMC-1A with ALMA
Authors: Hanawa Tomoyuki , Sakai Nami , Yamamoto Satoshi 
Published: June 2022

Abstract
TMC-1A is a protostellar source harboring a young protostar, IRAS 04365+2353, and shows highly asymmetric features of a few 100 au scale in its molecular emission lines. Blueshifted emission is much stronger in the CS (J = 5–4) line than redshifted emission. This asymmetry can be explained if the gas accretion is episodic and takes the form of cloudlet capture, given that the cloudlet is approaching toward us. The gravity of the protostar transforms the cloudlet into a stream and changes its velocity along the flow. The emission from the cloudlet should be blueshifted before the periastron, while it should be redshifted after the periastron. If a major part of cloudlet has not reached the periastron, the former should be dominant. We perform hydrodynamical simulations to examine the validity of the scenario. Our numerical simulations can reproduce the observed asymmetry if the orbit of the cloudlet is inclined to the disk plane. The inclination can explain the slow infall velocity observed in the C18O (J = 2–1) line emission. Such episodic accretion may occur in various protostellar cores since actual clouds could have inhomogeneous density distributions. We also discuss the implication of the cloudlet capture on observations of related objects.