bluuebunny/crossref_metadata_2025_split huggingface dataset:
Responses to natural gas development differ by season for two migratory ungulates
Authors: Sandoval Lambert Mallory , Sawyer Hall , Merkle Jerod A. 
Published: May 2022

AbstractWhile migrating, animals make directionally persistent movements and may only respond to human‐induced rapid environmental change (HIREC), such as climate and land‐use change, once a threshold of HIREC is surpassed. In contrast, animals on other seasonal ranges (e.g., winter range) make more localized and tortuous movements while foraging and may have the flexibility to adjust the location of their range and the intensity of use within it to minimize interactions with HIREC. Because of these seasonal differences in movement, animals on seasonal ranges should avoid areas that contain any level of HIREC, however, during migration, animals should use areas that contain low levels of HIREC, avoiding it only once a threshold of HIREC has been surpassed. We tested this hypothesis using a decade of GPS collar data collected from migratory mule deer (Odocoileus hemionus; n = 56 migration, 143 winter) and pronghorn (Antilocapra americana; n = 70 migration, 89 winter) that winter on and migrate through a natural gas field in western Wyoming. Using surface disturbance caused by well pads and roads as an index of HIREC, we evaluated behavioral responses across three spatial scales during winter and migration seasons. During migration, both species tolerated low levels of disturbance. Once a disturbance threshold was surpassed, however, they avoided HIREC. For mule deer, thresholds were consistently ~3%, whereas thresholds for pronghorn ranged from 1% to 9.25% surface disturbance. In contrast to migration, both species generally avoided all levels of HIREC while on winter range. Our study suggests that animal responses to HIREC are mediated by season‐specific movement patterns. Our results provide further evidence of ungulates avoiding human disturbance on winter range and reveal disturbance thresholds that trigger mule deer and pronghorn responses during migration: information that managers can use to maintain the ecological function of migration routes and winter ranges.
Schnurri 3 promotes Th2 cytokine production during the late phase of T‐cell antigen stimulation
Authors: Cunha Christina , Koike Toru , Seki Yoichi , Yamamoto Mutsumi , Iwashima Makio 
Published: May 2022

AbstractTh1 and Th2 polarization is determined by the coordination of numerous factors including the affinity and strength of the antigen‐receptor interaction, predominant cytokine environment, and costimulatory molecules present. Here, we show that Schnurri (SHN) proteins have distinct roles in Th1 and Th2 polarization. SHN2 was previously found to block the induction of GATA3 and Th2 differentiation. We found that, in contrast to SHN2, SHN3 is critical for IL‐4 production and Th2 polarization. Strength of stimulation controls SHN2 and SHN3 expression patterns, where higher doses of antigen receptor stimulation promoted SHN3 expression and IL‐4 production, along with repression of SHN2 expression. SHN3‐deficient T cells showed a substantial defect in IL‐4 production and expression of AP‐1 components, particularly c‐Jun and Jun B. This loss of early IL‐4 production led to reduced GATA3 expression and impaired Th2 differentiation. Together, these findings uncover SHN3 as a novel, critical regulator of Th2 development.
Exploration of structural, electronic, optical, mechanical, thermoelectric, and thermodynamic properties of XInO3 (X = As, Sb) compounds for energy harvesting applications
Authors: Manzoor Mumtaz , Iqbal Muhammad Waqas , Sharma Ramesh , Abraham Jisha Annie 
Published: May 2022

SummaryStructural, optoelectronic, elastic, transport, and thermodynamic properties of lead‐free simple face‐centered cubic perovskite compounds XInO3 (X = As, Sb) are figured in the framework of first‐principles calculation. The attained optimized lattice constants are comparable to the previous theoretical data. Electronic band structures and density of states (DOS) have advocated that the electronic bandgap of studied materials lie in the semiconductor region with an indirect band gap of 0.133 and 1.329 eV for AsInO3 and SbInO3, respectively. The participation of O‐2p orbital electrons near the Fermi level is maximum as compared to the rest of the elements in both the investigated perovskites as examined in DOS. We have computed the optical properties with real and imaginary dielectric functions and they prescribe utmost diffraction and absorption in the visible region in both compounds. Furthermore, we have determined the elastic parameters like bulk modulus, elastic constants, Pugh's ratio, and Poisson's ratio. It is perceived from the results of elastic properties that the studied materials are found to be ductile, anisotropic, and also mechanically stable. To determine the material nature and dynamics, we have also calculated the temperature and chemical potential dependence of thermal and thermodynamic properties and results recommended, due to which they could be considered as appropriate candidates for solar energy harvesting based applications Using a quasi‐harmonic model, the thermodynamic properties at high temperature and pressure are also estimated and studied for the first time.
A building information modeling‐fire dynamics simulation integrated framework for the simulation of passive fire protection in a mid‐scale cross‐laminated timber compartment: Numerical implementation and benchmarking
Authors: Sun Qi , Turkan Yelda , Fischer Erica C. 
Published: May 2022

AbstractConstruction fires are a big threat to worker safety and property safety. Mass timber buildings under construction are largely unprotected as they are not yet equipped with active fire protection systems. With the addition of Types IVA, B, and C, the 2021 International Building Code adopted stricter requirements for mass timber buildings that are under construction. Cross‐laminated timber (CLT) is used as the primary structural element for high‐rise mass timber buildings. However, to date, limited number of research studies investigated the impact of passive fire protection for CLT buildings that are under construction. To facilitate a better understanding of construction fires and their consequences, it is necessary to develop a numerical modeling solution for the early phases of a CLT construction project, which can be achieved by using building information models together with fire dynamics simulation (FDS). However, the numerical modeling technique must be benchmarked against experimental data first to then extrapolate the modeling technique to explore other parameters and conduct FDS analysis. Therefore, this paper develops and benchmarks a numerical modeling solution against a mid‐scale CLT compartment fire test by applying the FDS tool to simulate the fire behavior within the CLT compartment. The FDS analysis results are expected to validate the practicality of simulating the fire behavior in CLT structures using the numerical model proposed in this study. The overarching goal of this study is therefore to develop a comprehensive numerical modeling solution to simulate and assess passive fire protection sequencing in CLT buildings that are under construction.
A novel dynamic adaptive unstructured mesh algorithm for simulating multi‐object relative motion in incompressible fluid
Authors: Su Xiaohui , Zhang Kaixuan , Zhao Yong , Zhang Mingliang , Zhang Jiantao 
Published: May 2022

AbstractA novel dynamic adaptive unstructured mesh (DAUM) algorithm is proposed to solve incompressible multi‐object relative motion (MORM). The DAUM algorithm, consisting of exponential function deformation, adaptive edge swapping, and area Laplace smoothing, can greatly improve dynamic mesh robustness and perfectly overcome mesh skewness. The core of DAUM is the adaptive edge swapping inspired by Delaunay triangulation, which is distinguished from traditional edge swapping. The adaptive edge swapping can fully consider the relationship of neighbor elements only using Delaunay triangulation. Meanwhile, the implementation and reliability of adaptive edge swapping are better than the traditional edge swapping method due to eliminating the interference of the non‐convex polygon, so more code remedies can be avoided. Using the DAUM, none of the vertices is inserted or deleted so that the manipulation of the dynamic mesh is easily implemented and maintains computational efficiency in the process of mesh motion. Three representative geometries are used to assess the performance of the DAUM in MORM. To systematically analyze the advantages of DAUM, two relatively moving cylinders have been numerically investigated in incompressible flow. The inline force and lift force profiles on two cylinders are obtained and analyzed by using the flow field information. Three interaction stages are divided based on the parameter G and the interactional intensity of two inner anticlockwise vortices is considered as the division criteria. At the running process of the DAUM algorithm, the dynamic mesh quality is well controlled and remains in the high‐quality range based on the aspect ratio (AR) criterion. The results indicate that the proposed DAUM algorithm can properly solve the difficulties caused by MORM, especially for period oscillation motion.
Physiological instability is linked to mortality in primary central nervous system lymphoma: A case–control fMRI study
Authors: Poltojainen Valter , Kemppainen Janette , Keinänen Nina , Bode Michaela , Isokangas Juha‐Matti , Kuitunen Hanne , Nikkinen Juha , Sonkajärvi Eila , Korhonen Vesa , Tuovinen Timo , Järvelä Matti , Huotari Niko , Raitamaa Lauri , Kananen Janne , Korhonen Tommi , Tetri Sami , Kuittinen Outi , Kiviniemi Vesa 
Published: May 2022

AbstractPrimary central nervous system lymphoma (PCNSL) is an aggressive brain disease where lymphocytes invade along perivascular spaces of arteries and veins. The invasion markedly changes (peri)vascular structures but its effect on physiological brain pulsations has not been previously studied. Using physiological magnetic resonance encephalography (MREGBOLD) scanning, this study aims to quantify the extent to which (peri)vascular PCNSL involvement alters the stability of physiological brain pulsations mediated by cerebral vasculature. Clinical implications and relevance were explored. In this study, 21 PCNSL patients (median 67y; 38% females) and 30 healthy age‐matched controls (median 63y; 73% females) were scanned for MREGBOLD signal during 2018–2021. Motion effects were removed. Voxel‐by‐voxel Coefficient of Variation (CV) maps of MREGBOLD signal was calculated to examine the stability of physiological brain pulsations. Group‐level differences in CV were examined using nonparametric covariate‐adjusted tests. Subject‐level CV alterations were examined against control population Z‐score maps wherein clusters of increased CV values were detected. Spatial distributions of clusters and findings from routine clinical neuroimaging were compared [contrast‐enhanced, diffusion‐weighted, fluid‐attenuated inversion recovery (FLAIR) data]. Whole‐brain mean CV was linked to short‐term mortality with 100% sensitivity and 100% specificity, as all deceased patients revealed higher values (n = 5, median 0.055) than surviving patients (n = 16, median 0.028) (p < .0001). After adjusting for medication, head motion, and age, patients revealed higher CV values (group median 0.035) than healthy controls (group median 0.024) around arterial territories (p ≤ .001). Abnormal clusters (median 1.10 × 105mm3) extended spatially beyond FLAIR lesions (median 0.62 × 105mm3) with differences in volumes (p = .0055).
Dissecting the impact of bromodomain inhibitors on the Interferon Regulatory Factor 4‐MYC oncogenic axis in multiple myeloma
Authors: Agnarelli Alessandro , Mitchell Simon , Caalim Gillian , Wood C. David , Milton‐Harris Leanne , Chevassut Timothy , West Michelle J. , Mancini Erika J. 
Published: May 2022

AbstractB‐cell progenitor fate determinant interferon regulatory factor 4 (IRF4) exerts key roles in the pathogenesis and progression of multiple myeloma (MM), a currently incurable plasma cell malignancy. Aberrant expression of IRF4 and the establishment of a positive auto‐regulatory loop with oncogene MYC, drives a MM specific gene‐expression program leading to the abnormal expansion of malignant immature plasma cells. Targeting the IRF4‐MYC oncogenic loop has the potential to provide a selective and effective therapy for MM. Here we evaluate the use of bromodomain inhibitors to target the IRF4‐MYC axis through combined inhibition of their known epigenetic regulators, BRD4 and CBP/EP300. Although all inhibitors induced cell death, we found no synergistic effect of targeting both of these regulators on the viability of MM cell‐lines. Importantly, for all inhibitors over a time period up to 72 h, we detected reduced IRF4 mRNA, but a limited decrease in IRF4 protein expression or mRNA levels of downstream target genes. This indicates that inhibitor‐induced loss of cell viability is not mediated through reduced IRF4 protein expression, as previously proposed. Further analysis revealed a long half‐life of IRF4 protein in MM cells. In support of our experimental observations, gene network modeling of MM suggests that bromodomain inhibition is exerted primarily through MYC and not IRF4. These findings suggest that despite the autofeedback positive regulatory loop between IRF4 and MYC, bromodomain inhibitors are not effective at targeting IRF4 in MM and that novel therapeutic strategies should focus on the direct inhibition or degradation of IRF4.
Evaluating the impact of adverse childhood experiences on medication use
Authors: DePuy Ashley M. , Patterson Michelle L. , Rodriguez Natalie P. , Patel‐Shori Nima M. , Yu Daohai , Jacob Regina 
Published: May 2022

AbstractIntroductionSocioeconomic adversities in early life predicts adulthood diseases. However, literature evaluating childhood adversity and number of medications prescribed is limited.ObjectivesOur aim is to assess the number of disease states, chronic medications prescribed, and discrepancies that may be encountered on a patient and system level.MethodsThis single‐center, prospective cohort study included adults ≥18 years old who provided informed consent. Participants were asked to bring all medications to their visit where a medication history was conducted. Medication discrepancies from the interview and patient chart were stratified by patient or system error. Participants were asked to answer a questionnaire regarding their beliefs about medications and their adherence patterns.ResultsThirty‐eight patients were enrolled over 27 months. The median number of disease states and chronic medications per patient was 6 (4–9) and 9.5 (5–14), respectively. The median adverse childhood event (ACE) score was 5 (3–7). Patients with ACE scores <5 had a median of 4.5 (3–7) disease states compared with a median of 6.5 (4–10) for patients with scores ≥5 (P = 0.0638). Patients with ACE scores <5 were taking a median of 3.5 (3‐8.5) chronic medications compared with 12.5 (6–16) for patients with scores ≥5 (P = 0.0025). There were a total of 105 patient discrepancies and 167 system discrepancies in relation to chronic medication use. Patients with ACE scores <5 had a median of 1.5 (1‐2.5) patient discrepancies and 3 (1–5) system discrepancies. Patients with ACE scores ≥5 had a median of 3 (1–4) patient discrepancies and 4 (1–6) system discrepancies.ConclusionPatients with higher ACE scores had more comorbid disease states and chronic medications. Patient and system medication discrepancies were abundant among all patients, regardless of ACE score.
The role of precautionary and speculative demand in the global market for crude oil
Authors: Cross Jamie L. , Nguyen Bao H. , Tran Trung Duc 
Published: May 2022

SummaryContemporary structural models of the global market for crude oil jointly specify precautionary and speculative demand shocks as a composite shock, named a storage demand shock. We resolve this identification problem and examine the effects of these distinct shocks, along with conventional demand and supply shocks, on the global price of crude oil. We find that uncertainty driven precautionary demand for crude oil is, on average, the primary driver of real price of oil fluctuations that have previously been associated with storage demand shocks. Historically, these shocks have had distinct effects on the real oil price dynamics since the 1970s.
Vibration‐induced symmetry breaking in hybrid light‐matter dimer states
Authors: Shen Chih‐En , Hsu Sheng‐Chieh , Tsai Hung‐Sheng , Hsu Liang‐Yan 
Published: May 2022

AbstractWe investigate the influence of vibronic coupling on a molecular dimer strongly coupled to a single cavity mode. In the framework of the Holstein‐Tavis‐Cummings model, the energy structure of the molecular dimer is analyzed by numerical exact diagonalization and perturbation theory. Under numerical exact diagonalization, we find that the degeneracy of lower polaritons vanishes in the presence of vibronic coupling. Under the second‐order degenerate perturbation theory, the degeneracy breaking of lower polaritons can be associated with asymmetric indirect interactions mediated by the upper polaritons and the dark states. The consistency of the two approaches confirms the robustness of our simulations, indicating that the vibration‐induced symmetry breaking should be experimentally observed.
How Creative Self‐Concept Leads to Happiness: A Multilevel Chain Mediating Model
Authors: Li Pin , Zhang Zhitian Skylor , Zhang Yanna 
Published: May 2022

ABSTRACTRecent research has shown that creative self‐concept might be not only a path to people's creativity but also a path to their positive affect. This study proposed and examined the underlying mechanisms of how creative self‐concept is associated with positive affect through the mediating role of people's daily creative behavior and creative self‐assessment. We recruited 101 Chinese undergraduate students to report their creative behavior, creative self‐assessment, and experiences of positive emotion states each day for 14 days. A multilevel structural equation model was conducted. Results confirmed the mediating role of creative self‐assessment and the chain‐mediating role of creative behavior and creative self‐assessment between creative self‐concept and positive affect. The direct effect of creative behavior on positive affect was not verified. These findings highlight the role that creative self‐concept plays in everyday activities and everyday well‐being and show the importance of creative self‐assessment in creativity education and mental health care.
A membrane‐protected micro‐solid‐phase extraction method based on molecular imprinting and its application to the determination of local anesthetics in cosmetics
Authors: Jian Pengli , Muhammad Turghun , Wei Aixia , Wu Beibei , Zhou Tiantian 
Published: May 2022

As local anesthetics that are illegally added to cosmetics are harmful to consumer health, it is necessary to establish an efficient method for detecting these substances. Herein, a molecularly imprinted polymer (bupivacaine) was prepared by bulk polymerization and packed into a hollow fiber for use as an extraction phase to fabricate a membrane‐protected micro‐solid‐phase extraction device. The optimal values of the influencing parameters for the microextraction process were as follows: a sample solution pH of 9.0, a loading and washing time of 2 h, and an elution time of 32 min. A gas chromatography‐mass spectrometry method was established for the determination of local anesthetics and coupled with the microextraction method to successfully detect local anesthetics in cosmetic samples. The calibration curve for the proposed method was linear in the range of 0.4–50 mg/L and showed a good correlation coefficient (r2). The limits of detection for local anesthetics were in the range of 0.01–0.71 mg/L. The molecularly imprinted polymer exhibited good imprinting and selectivity, the micro‐solid‐phase extraction device was simple and inexpensive and fabrication was reproducible. The combination of molecular imprinting technology, membrane separation, and micro‐solid‐phase extraction methods used in this study can potentially be applied to pretreat local anesthetics in cosmetic samples.
The American Broncho‐Esophagological Association Position Statement on Swallowing Fluoroscopy
Authors: Dhar Shumon Ian , Nativ‐Zeltzer Nogah , Starmer Heather , Morimoto Linda Nayeli , Evangelista Lisa , O'Rourke Ashli , Fritz Mark , Rameau Anaïs , Randall Derrick R. , Cates Daniel , Allen Jacqueline , Postma Gregory , Kuhn Maggie , Belafsky Peter 
Published: May 2022

ObjectivesTo develop an expert consensus statement on the clinical use of swallowing fluoroscopy in adults that reduces practice variation and identifies opportunities for quality improvement in the care of patients suffering from swallowing impairment.MethodologyA search strategist reviewed data sources (PubMed, Embase, Cochrane, Web of Science, Scopus) to use as evidence for an expert development group to compose statements focusing on areas of controversy regarding swallowing fluoroscopy. Candidate statements underwent two iterations of a modified Delphi protocol to reach consensus.ResultsA total of 2184 publications were identified for title and abstract review with 211 publications meeting the criteria for full text review. Of these, 148 articles were included for review. An additional 116 publications were also included after reviewing the references of the full text publications from the initial search. These 264 references guided the authors to develop 41 candidate statements in various categories. Forty statements encompassing patient selection, fluoroscopic study choice, radiation safety, clinical team dynamics, training requirements, videofluoroscopic swallow study and esophagram techniques, and interpretation of swallowing fluoroscopy met criteria for consensus. One statement on esophagram technique reached near‐consensus.ConclusionsThese 40 statements pertaining to the comprehensive use of swallowing fluoroscopy in adults can guide the development of best practices, improve quality and safety of care, and influence policy in both the outpatient and inpatient settings. The lack of consensus on some aspects of esophagram technique likely reflects gaps in knowledge and clinical practice variation and should be a target for future research. Laryngoscope, 133:255–268, 2023
Wide‐Angle Scattering Halo Analysis and the Evolution of Oriented Amorphous Structure after Elongation Jumps in Some Elastomers
Authors: Stribeck Almut , Schneider Konrad , Pöselt Elmar , Eling Berend , Roth Stephan V. 
Published: May 2022

AbstractAmorphous and low‐crystallinity thermoplastic polyurethane elastomers are shot back and forth between two elongation levels ( and ) and observed between the excitations for 10 s using wide‐angle X‐ray scattering (WAXS) (50 Hz). For orientation analysis, the fiber patterns are projected, expanded in multipoles, and discussed as a function of relaxation time. Normalized WAXS suggests that the oriented halo observed during extension is predominantly due to selective extinction of unfavorably oriented probes (chain bundles). During retraction, neighborhoods and thus clusters are restored. Discussed are the relaxation curves depending on material and the number of load cycles. The separation of the halo into narrow rings introduces “bundle airiness” as a second coordinate. The now bivariate cluster density is the product of two univariate functions. Its factor “airiness distribution” seems to be a material property which is not changed by annealing. In contrast, the bivariate preferred orientation is not product‐separable. Especially with harder materials it shows two bundle ensembles of different airiness. Interactions between the ensembles explain complex trajectories of the orientation–relaxation curves. The formation of the additional airier oriented component is inhibited by annealing in most of the materials studied. In contrast, multiple load changes promote its formation.