bluuebunny/crossref_metadata_2025_split huggingface dataset:
Structural validity and psychometric properties of the Anger Rumination Scale: an analysis of invariance by gender, age and sample type in a community and a clinical sample
Authors: Rodríguez Manuel González , Ibañez Ignacio , Marrero Rosario J , Fumero Axit , Lorenzo Laureano , Rascón Pilar , Peñate W 
Published: June 2022

Abstract
We present the structural validity of the Anger Rumination Scale (ARS) in two samples: a community sample of 536 individuals and a clinical sample of 97 individuals. An exploratory factor analysis isolated three factors that explained 57.5% of the variance after rotation; a confirmatory factor analysis indicated a good fit of the data to a model composed of three factors, which we called 1) angry memories (α = .90), 2) analysis of past anger events (α = .88), and 3) thoughts of revenge (α = .76). A multigroup CFA showed that the structural validity of the ARS had metric invariance by gender, age group (i.e., younger than 25 years vs. or older than 25 years) and sample type (i.e., community vs. clinical sample). As regards incremental validity, once depressive rumination was controlled for, angry memories and analysis of past anger events predicted anxiety and depression symptoms. Results are discussed according to the studies reviewed. We suggest that anger rumination and depressive rumination are repetitive processes that should be taken into account when assessing anxiety and mood disorders.
Recruitment of circulating antigen presenting cells to the retina is necessary for induction of autoimmune retinitis
Authors: McPherson Scott W. , Heuss Neal D. , Abedin Md. , Roehrich Heidi , Pierson Mark J. , Gregerson Dale S. 
Published: June 2022

Abstract
BackgroundCharacterizing immune cells and conditions that govern their recruitment and function in autoimmune diseases of the nervous system or in neurodegenerative processes is an area of active investigation. We sought to analyze the origin of antigen presenting cells associated with the induction of retinal autoimmunity using a system that relies on spontaneous autoimmunity, thus avoiding uncertainties associated with immunization with adjuvants at remotes sites or adoptive transfer of in-vitro activated T cells. MethodsR161H mice (B10.R3 background), which spontaneously and rapidly develop severe autoimmune retinitis (AR), were crossed to CD11cDTR/GFP mice (B6/J) allowing us to track the recruitment to and/or expansion within the retina of activated, antigen presenting cells (GFPhi cells) in R161H+/- x CD11cDTR/GFP F1 mice relative to the course of AR. Parabiosis between R161H+/- x CD11cDTR/GFP F1 mice and B10.R3 x B6/J F1 (wild type recipient) mice was done to explore the origin and phenotype of antigen presenting cells crucial for the induction of autoimmunity. Analysis was done by retinal imaging, flow cytometry, and histology. ResultsOnset of AR in R161H+/- x CD11cDTR/GFP F1 mice was delayed relative to B10.R3-R161H+/- mice revealing a disease prophase prior to frank autoimmunity that was characterized by expansion of GFPhi cells within the retina prior to any clinical or histological evidence of autoimmunity. Parabiosis between mice carrying the R161H and CD11cDTR/GFP transgenes and transgene negative recipients showed that recruitment of circulating GFPhi cells to retinas was required for induction of AR. ConclusionsOur results here contrast with our previous findings showing that retinal antigen presenting cells expanding in response to either sterile inflammatory injury or neurodegeneration were derived from myeloid cells within the retina or optic nerve thus highlighting a unique facet of retinal autoimmunity.
Rotated Digit Recognition by Variational Autoencoders with Fixed Output Distributions
Authors: Yevick David 
Published: June 2022

Abstract
This paper demonstrates that a simple modification of the variational autoencoder (VAE) formalism enables the method to identify and classify rotated and distorted digits. In particular, the conventional objective (cost) function employed during the training process of a VAE both quantifies the agreement between the input and output data records and ensures that the latent space representation of the input data record is statistically generated with an appropriate mean and standard deviation. After training, simulated data realizations are generated by decoding appropriate latent space points. Since, however, standard VAE:s trained on randomly rotated MNIST digits cannot reliably distinguish between different digit classes since the rotated input data is effectively compared to a similarly rotated output data record. In contrast, an alternative implementation in which the objective function compares the output associated with each rotated digit to a corresponding fixed unreferenced reference digit is shown here to discriminate accurately among the rotated digits in latent space even when the dimension of the latent space is 2 or 3.
Association of age at first birth and risk of non-alcoholic fatty liver disease in women: evidence from the NHANES
Authors: Yang Huan-huan , Chen Guo-Chong , Zhou Meng-Ge , Xie Li-Feng , Jin Yuan-Yuan , Chen Hao-Tian , Chen Ze-Kun , Kong Yu-Hao , Li Zhi-Hui 
Published: June 2022

Abstract
Background
Numerous studies have suggested that age at first birth (AFB) is inversely associated with metabolic diseases, but positively associated with liver cancer in women. Non-alcoholic fatty liver disease (NAFLD) is a canonical example of metabolic dysfunction and inflammation-based liver disease, while the association between AFB and risk of NAFLD remains unclear. We aimed to investigate the association between AFB and the odds of NAFLD in women.
Methods
Women older than 20 years at the time of the survey were analyzed using National Health and Nutrition Examination Survey (NHANES) data from 1999 to 2018 in the US. AFB was obtained with self-administered questionnaires. NAFLD was diagnosed as fatty liver index ≥ 60. Odds ratios (ORs) and 95% confidence intervals (CI) were estimated using logistic regression models.
Results
Of the 12,188 women included in this study, 5,670 (46.5%) had NAFLD. Compared to individuals with AFB of 30–32 years old (reference group), the fully adjusted ORs and 95% CI in women with AFB < 18 years, 18–20 years, 21–23 years, and 24–26 years were 1.59 (95% CI: 1.18, 2.13), 1.58 (95% CI: 1.20, 2.08), 1.38 (95% CI: 1.04, 1.83), and 1.33 (95% CI: 1.01–1.77), respectively. Yet there was no significant difference between AFB of 27–29 years, 33–35 years, or > 35 years compared with the reference group.
Conclusions
Women with younger AFB have higher odds of NAFLD in later life. Policymakers should consider focusing on those with earlier AFB for screening and prevention of NAFLD.
Urinary measurement of epigenetic DNA modifications and 8-oxodG as a possible noninvasive markers of colon cancer evolution
Authors: Skalska-Bugala Aleksandra , Siomek-Gorecka Agnieszka , Banaszkiewicz Zbigniew , Olinski Ryszard , Rozalski Rafal 
Published: June 2022

Abstract
The active DNA demethylation mechanism involves 5-methylcytosine (5-mCyt) enzymatic oxidation with the subsequent formation of 5-hydroxymethylcytosine (5-hmCyt), which can be further oxidized to 5-formylcytosine (5-fCyt) and 5-carboxylcytosine (5-caCyt). The products of active DNA demethylation are released into the bloodstream and eventually also appear in urine. We used online two-dimensional ultraperformance liquid chromatography with tandem mass spectrometry (2D-UPLC-MS/MS) to compare DNA methylation marks in colorectal cancer and pre-cancerous condition in urine. The study included four groups of subjects: healthy controls, patients with inflammatory bowel disease (IBD), persons with adenomatous polyps (AD), and individuals with colorectal cancer (CRC). We have found that the level of 5-fCyt in urine was lowest in all patients’ groups, but the statistical significance were observed only for CRC and polyp groups than in control group. The level of 5-hmCyt was significantly higher only in CRC group (2.1 vs 2.3 nmol/mmol creatinine). Interestingly, we have found highly statistically significant correlation of 5-hydroxymethyluracil with 5-hydroxymethylcytosine, 5-(hydroxymethyl)-2′-deoxycytidine, 5-methyl-2′-deoxycytidine and 5-(hydroxymethyl)-2′-deoxyuridine in CRC patients group.
Social media improves farmers knowledge of invasive alien species
Authors: Chen Dongming , Peng Ya , Zhang Liyun , Zhu Min , Si Xiaozheng 
Published: June 2022

Abstract
Management of biological invasions is a tremendous challenge for both ecological and socioeconomic systems. Public education positively affects stakeholder knowledge and facilitate management of invasive alien species (IAS). However, our knowledge of the role of social media in public knowledge of IAS is elusive for the majority of invaders. In this study, we used Spodoptera frugiperda (Lepidoptera; noctuidae), one of the most notorious invasive insects in China, as a case to test the hypothesis that social media could improve farmers’ knowledge of IAS. We conducted household questionnaires at the village level in the China-Myanmar-Laos border region (China) and used quantitative descriptions and binary logistic regressions in statistical analyses. Our results indicated that farmers often used 12 social media applications on smartphones (SMASs) and obtained information about S. frugiperda from six SMASs, with high preferences for WeChat and TikTok, and obtained a high level of knowledge of S. frugiperda from SMASs; further, socio-demographic factors and of SMAS-based information significantly influenced farmers’ knowledge of S. frugiperda. We suggested that well-designed and conducted educational programs based on the use of SMASs could improve the performance of IAS management, and the government plays an important role in such a circumstance. Our findings contribute to theoretical insights into the role of public education in IAS improvement, and empirical bases for the optimization of IAS management.
Endovascular Aortic Arch Repair with Chimney Technique for Pseudoaneurysm
Authors: Luo Ming-yao , Zhang Xiong , Fang Kun , Guo Yuan-yuan , Chen Dong , Lee Jason T. , Shu Chang 
Published: June 2022

Abstract
Background: Aortic pseudoaneurysm is a life-threatening clinical condition, and thoracic endovascular aortic repair (TEVAR) has been reported to have a relatively satisfactory effect in aortic pathologies. We summarized our single-centre experience using chimney TEVAR for aortic arch pseudoaneurysms with inadequate landing zones.Methods: A retrospective study was conducted from October 2015 to August 2020, 32 patients (64.1±15.0 years, range 28-81; 29 men) with aortic arch pseudoaneurysms underwent chimney TEVAR to exclude an aortic lesion and reconstruct the supra-aortic branches, including 3 innominate artery, 12 left common carotid arteries and 29 left subclavian arteries. Follow-up computed tomography was suggested before discharge; at 3, 6, and 12 months; and yearly thereafter.Results: Forty-four related supra-aortic branches were well preserved and the technical success rate was 100%. The Type Ia endoleaks occurred in 3 (9%) patients. Two patients were lost to follow-up and 4 patients died during the follow-up period. The median follow-up was 46.5±14.3 (range, 4.5-60) months. One patient died due to acute myocardial infarction just 10 days after chimney TEVAR and the other 3 patients passed away at 1.5 months, 20 months and 31 months with non-aortic reasons. The 4.5-year survival estimate was 84.4%. The primary patency rate of the target supra-arch branch vessels was 97.7% (43/44), and no other aorta-related reinterventions and severe complications occurred.Conclusion: For aortic arch pseudoaneurysms with inadequate landing zones for TEVAR, the chimney technique seems to be feasible, with acceptable mid-term outcomes, and it could serve as an alternative minimally invasive approach to extend the landing zone. Slow flow type Ia endoleak could be treated conservatively after chimney TEVAR. Additional experience is needed, and the long-term durability of chimney TEVAR requires further follow-up.
Graph-based system for predictive epidemiological surveillance
Authors: Akagi Javier Tadashi , García-Torres Miguel , Pérez-Estigarribia Pastor Enmanuel , Bernal Diego Andrés Flores , Grillo Sebastian Alberto , Mello-Román Julio César , Noguera José Luis Vázquez , Muñoz Mara Griselda , Pedrozo Maria Esther , Cabrera Sandra Verónica Irala , Buzarquis Victor Guillermo Sequera 
Published: June 2022

Abstract

One of the problems associated with the pandemic caused by COVID-19 is the search of positive cases from suspected cases. Another problem is predicting potentially severe or fatal cases from positive COVID-19 cases. Data associated with transmissible disease cases such as COVID-19 can be structured in the form of contact and infection graphs. In this sense, this work proposes a computer system based on graphs for monitoring probable cases and prediction of critical cases of COVID-19. These massive records could be used by teams of epidemiologists responsible for health surveillance to identify profiles with a greater possibility of being positive or severe cases of COVID-19. Monitoring is based on contact graphs and prediction employing descriptive and predictive models from data provided by the General Directorate of Health Surveillance.
Local environment drives rapid shifts in composition and phylogenetic clustering of seagrass microbiomes
Authors: Kardish Melissa , Stachowicz John 
Published: June 2022

Abstract
Plant microbiomes depend on environmental conditions, stochasticity, species, and genotype identity. Eelgrass (Zostera marina) is a unique system for plant-microbe interactions as a physiologically-challenged, marine angiosperm growing in anoxic sediment, periodic exposure to air at low tide, and gradients in water clarity and flow. We tested the influence of host origin versus environment on microbiome composition by transplanting 768 plants among four sites within Bodega Harbor, CA. Over three months following transplantation, we sampled microbial communities monthly on leaves and roots and sequenced the V4-V5 region of the 16S rRNA gene to assess community composition. The main driver of leaf and root microbiome composition was destination site; more modest effects of origin site did not last over a month. Community phylogenetic analyses suggested that environmental filtering structures these communities, but the strength and nature of this filtering varies among sites and over time. We demonstrate that local environmental differences create rapid shifts in associated microbial community composition with potential functional implications for hosts under shifting environmental conditions.
Identification of coronary artery lesions and tactics of surgical treatment in patients with chronic lower limb ischemia
Authors: Arakelyan V. S. , Lysyy R. N. , Gagloeva A. S. 
Published: June 2022

Introduction. Ischemic heart disease is undoubtedly the main factor that significantly aggravates the condition of patients with chronic lower limb ischemia in the perioperative period.Aim. To establish the expediency of mandatory performance of selective polypositional coronary angiography in patients with chronic ischemia of the lower extremities to determine the stages of surgical intervention and prevent cardiac complications.Materials and methods. The study included 285 patients, treated to the Department of arterial pathology surgery of the Bakulev National Medical Research Center of Cardiovascular Surgery with a diagnosis of chronic lower limb ischemia. The patients were divided into 2 groups. The main group included 139 patients admitted in 2016. The control group – 146 patients admitted in 1989. In the main group, all patients underwent coronary angiography. In the control group, coronary angiography was performed only in patients with a clinical picture of coronary artery disease or in asymptomatic patients after positive stress tests.Results and discussion. After analysis of coronary angiograms in patients of the main group, out of 139 patients included in the study, 124 (89.2%) had a lesion of at least 1 coronary artery >50%; and in 101 (72.7%) patients, at least 1 coronary artery was affected >70%. In the main group, cardiac complications were noted in 6 (4.32%) patients, while in the control group they were detected in 21 (14.4%) cases. These complications appeared due to the underestimation of the state of the coronary bed, based only on the results of stress tests.Conclusions. Selective polypositional coronary angiography is the main method for detecting asymptomatic significant coronary artery disease in patients with CLCI, which improves the immediate results of surgical treatment by reducing the incidence of cardiac complications.
El conocimiento ético profesional docente y su presencia en la inclusión de las tecnologías en el contexto educativo presente
Authors: Gómez-Trigueros Isabel María , Ortega-Sánchez Delfín 
Published: June 2022

El objetivo de este estudio es analizar el conocimiento ético profesional docente en el uso de las tecnologías del profesorado en formación. Partiendo del modelo Conocimiento Tecnológico Pedagógico Disciplinar (CTPD) para medir la correcta inclusión de las tecnologías en el aula, se ha llevado a cabo un estudio de diseño metodológico mixto de corte descriptivo. Los instrumentos utilizados han sido el cuestionario de escala Likert y la entrevista personal, ambos organizados en cuatro dimensiones sobre el conocimiento ético profesional, ético de la tecnología, ético tecnológico pedagógico y ético tecnológico disciplinar de los futuros docentes. El cuestionario se ha aplicado a una muestra de 632 profesores en formación de una universidad europea en el contexto de la COVID-19 y en la entrevista participaron 429 estudiantes.
Los hallazgos revelaron la escasa o nula formación en conocimientos éticos profesionales de los docentes en formación; la necesidad de profundizar en tales conocimientos para enfrentar el contexto actual, de pandemia y postpandemia de la educación y la importancia de incluir el componente ético en el modelo CTPD para una implementación correcta y ética de los recursos digitales en el aula.
FEATURES OF DIAGNOSIS OF NON-ALCOHOLIC FAT LIVER DISEASES IN PATIENTS WITH TYPE 2 DIABETES MELLITUS ACCORDING TO ULTRASOUND INVESTMENT DATA
Authors: Kravchun N. A. , Zemlyanitsina O. V. , Tyazhelova O. V. 
Published: June 2022

230 patients with type 2 diabetes mellitus (DM) were examined, of which 83 were diagnosed with non-alcoholic fatty liver disease (NAFLD) (36.1%). It is established that NAFLD is reliable
more common in obese and overweight patients (54.5 and 37.5%, respectively)
and only in 20.8% of patients with normal body weight. Among patients with type 2 diabetes with normal
body weight NAFLD is more common in women, and in overweight and obesity -
in men. Patients with type 2 diabetes and NAFLD, regardless of body weight, have abdominal
type of adipose tissue deposition. Changes in the size and structure of the pancreas in patients
with type 2 diabetes do not depend on changes in body weight and, most likely, develop comorbidly
with type 2 diabetes.
FEATURES OF ULTRASOUND INVESTIGATION THYROID GLAND IN PATIENTS WITH RECURRENCE NODAL NON-TOXIC GOAT
Authors: Tyazhelova O. V. , Khaziev Vadym 
Published: June 2022

According to the ultrasound examination of patients with postoperative recurrent goiter, it was found that the signs for recurrence of single-node goiter are: oval shape of the tumor with clear contours, reduced echogenicity, absence of calcifications and fluid component, clear capsule. To optimize the tactics of surgical treatment of patients with nodules
pathology of the thyroid gland, it is necessary to use intraoperative ultrasound examination of the neck, especially in multinodular goiter, when performing organ-preserving operations, as well as in malignant pathology of the thyroid gland, to detect pathological changes.
nodes of the neck.
FEATURES OF HORMONAL HOMEOSTASIS EARLY CHILDREN WITH CARDITAS RUNNING IN THE BACKGROUND CYTOMEGALOVIRUS INFECTION
Authors: Lezhenko G. O. , Borisenko T. V. 
Published: June 2022

The hormonal status of children with carditis has been studied. The interdependence of the formation of myocardial dysfunction and changes in the indicators of neurohumoral regulation is shown. In early children
age with carditis there is a new metabolic status, which is formed in the conditions of adaptation at
myocardial hypoxia and elevated left ventricular filling pressure, which is an adaptive-compensatory reaction.
MICROCIRCULAR CHANGES IN CHILDREN WITH OBESITY
Authors: Chumak S. O. 
Published: June 2022

The study analyzed the nature of microcirculatory disorders (MP) in 304 children and
adolescents and the influence on the microcirculation of various factors inherent in obesity. In 74% of children and
Adolescents with obesity have microcirculation disorders of varying degrees, in half of patients (51%) due to preclinical changes and functional MP, including 22.5% of patients
disorders of moderate severity of sympathetic-atonic form are revealed. It is shown that it is important
Insulin resistance (IR), hyperinsulinemia, have a place in the formation of MP in obesity.
hypertriglyceridemia and abdominal obesity, in the presence of which more severe functional disorders of microcirculation predominate in 70% of patients.
THE IMPACT OF 17β-ESTRADIOL ON THE HEME OXYGENASE ACTIVITY AND TBA-ACTIVE PRODUCTS LEVEL IN VESSELS OF OVARIECTOMIZED RATS WITH INSULIN RESISTANCE
Authors: Kiprych Tetiana , Nikitchenko I. V. , Gorbenko Nataliia 
Published: June 2022

The effect of 17β-estradiol on the heme oxygenase activity and TBA-active products level in vessels of variectomized rats with insulin resistance was investigated. Insulin resistance induced by high fructose diet in ovariectomized rats led to increase in heme oxygenase activity and TBA-active products level in vessels. Administration of 17β-estradiol prevented increase in heme oxygenase activity and TBA-active products level, that could be explained by amelioration of insulin resistance and normalization of prooxidant-antioxidant state and could be considered the one of possible mechanisms of vasoprotective estradiol effect.
Effects of the exercise mobile app and distance supervision on the functional performance of the older adults. Protocol of a clinical, randomized, controlled trial.
Authors: Kunitake André Issao , Dias Keoma Santos , Vegh Henrique Pereira , Ramos Leticia Garcia , Bossert Victor Gonçalves , Bezzera Hitanna dos Santos , Solai Maria Jucilane Soares , Corrêa Fernanda Ishida 
Published: June 2022

Objective: To check the effects of the exercise mobile app with face-to-face and distance supervision on the functional performance, postural balance, and lower limb strength of older adults. Methods: This is a protocol of a controlled, randomized, and blind clinical trial in which we will recruit older adults of both genders, who will be randomized into two types of training: a control group (exercises using a mobile app with face-to-face monitoring by the therapist) and an experimental group (exercises with a mobile app without face-to-face monitoring by the therapist). The training will be carried out with the free app "Exercício para idosos", which should be installed on the participants' smartphones. The participants should do the proposed exercises three times a week for eight consecutive weeks. The evaluations will be conducted in person pre-training and after the 12th and 24th sessions. Functional performance, postural balance, and lower limb strength will be assessed. The data in each evaluation will be compared as well as the difference between the groups. It is believed that physical exercise apps for older people will benefit both groups by improving functional capacity, postural balance, and lower limbs of older adults.