bluuebunny/crossref_metadata_2025_split huggingface dataset:
CM-generator: an approach for generating customized correlation matrices
Authors: Duarte Anderson , Martins Helgem , Oliveira Fernando 
Published: December 2022

Abstract

The simulation of random correlation matrices is an important procedure in different research areas. This study presents a method called Custom Matrix generator, which generates correlation matrices that always fulfill the appropriate mathematical conditions. In addition, we present an algorithm based on this method which can generate customized correlation matrices for different applications used in several studies. The method is efficient in terms of computational time and it minimizes errors in the process of generating customized correlation matrices.
Simultaneous thyroglossal duct cyst with parathyroid cyst - a case report
Authors: Gengyu Chen 
Published: December 2022

Abstract
Thyroglossal duct cysts (TDC) are common congenital deformities of the neck in children. Most of them are cysts formed by the thyroglossal ducts that do not disappear and degenerate in the early embryonic stage, and some residual structures are formed [1]. TDC exists alone and is rarely complicated by other congenital embryonic malformations. Only a few reports of TDC with branchial cleft cysts, thyroid cancer, thyroid hematoma, and epidermoid cysts have been reported [2-5]. However, the patient coexisted with TDC and parathyroid cyst (PC), a rare disease that has never been reported in the weapons literature. Therefore, we report a patient with a simultaneous TDC and a PC to explore the correlation between the two congenital anomalies.
A Dubious Pelvic Abscess in a patient with Familial Adenomatous Polyposis
Authors: Garcia Joana Lemos , Braga Miguel , Doutel Defilm , Barroca Rita , Fonseca Ricardo , Castela Joana , Rosa Isadora , Venâncio José , Claro Isabel 
Published: December 2022

Abstract
A 54-year-old female presented to the Emergency Department due to 1 month lower right quadrant abdominal pain, with fever in the last 2 days. Three years before, she had been diagnosed with Familial Adenomatous Polyposis and had undergone prophylactic total proctocolectomy with ileal pouch, with no perioperative complications. Blood analysis showed an elevated C-reactive protein (7.8mg/dL). The abdominopelvic CT showed an irregular pelvic collection with air bubbles, lined by a thickened enhancing wall, lymphadenopathies and mesenteric fat densification. Endoscopic evaluation showed bulging of the ileal pouch wall. These findings were suggestive of a pelvic abscess and the patient was empirically treated with piperacillin/tazobactam, with clinical improvement. Two months later, the symptoms recurred. CT scan was repeated, showing persistence of the previously described pelvic collection, in communication with the intestinal lumen, associated with a soft tissue infiltrative tumour in the mesentery and at the site of the previous ileostomy. Endoscopic evaluation showed, in the closed end of the pouch, two fistulous openings leading to an ulcerated and friable lesion. Ultrasound-guided biopsy revealed fascicles with elongated, spindled cells of uniform appearance and pale cytoplasm, set in a collagenous stroma, without signs of cytologic atypia. Immunohistochemistry showed nuclear beta-catenin staining. These findings were suggestive of a desmoid tumour. After a multidisciplinary meeting, a derivation ileostomy was placed and systemic treatment with tamoxifen was began. This case illustrates the importance of considering the patient as a whole, including knowledge of past medical and family history, that may alert to alternative diagnosis.
This case illustrates the importance of considering the patient as a whole, including knowledge of past medical and family history, that may alert to alternative diagnosis.
Childhood effortful control and adherence to physical distancing during COVID-19 pandemic: a 10-Year follow-up study
Authors: Croci Marcos Signoretti , Brañas Marcelo J. A. A , Hoffman Mauricio Scopel , Salto Ana Beatriz Ravagnani , Salum Giovanni Abrahão , Rohde Luis Augusto , Miguel Euripedes Constantino , Pan Pedro Mario 
Published: December 2022

Abstract
Physical distancing is a vital health measure to prevent pathogens from spreading during pandemics. Many factors, including personality characteristics, may influence the ability to adhere to these mitigation measures. However, no longitudinal research has studied temperament dimensions influencing physical distancing. Therefore, we aimed to investigate if childhood temperament dimensions as predictors of later difficulty in physical distancing during the COVID-19 pandemic. This study used data from the Brazilian High-Risk Cohort Study (BHRC). Five temperament dimensions were assessed at baseline with the self-report version of the Early Temperament Questionnaire-Revised Version (EATQ-R): effortful control (EC), fear, frustration, shyness, and surgency. In addition, the Coronavirus Health Impact Survey (CRISIS) Youth Self-Report assessed the difficulty in physical distancing during the COVID-19 pandemic, ten years after baseline. The factor structure of EATQ-R was generated by confirmatory factor analysis, and logistic regression models were used to determine temperament associations with difficulty distancing. Effortful control dimension emerged as a factor associated with lower levels of perceived difficulty in adhering to physical distancing (OR = 0.823, 95% CI: 0.691–0.979, p < 0.029). Therefore, EC trait can be a potential target for early intervention strategy for increasing adherence to safety measures during pandemics.
Prognostic value of Liver kinase B1 (LKB1) in Gastric Cancers Associates with Tumor Microenvironment Immunity
Authors: Chen Yongyi , Chen Siyu , Zhu Jing , Liu Xin , gong Wangang , Zhou Sihang , Xu Songxiao 
Published: December 2022

Abstract
Liver kinase B1 (LKB1) is a tumor suppressor gene whose inactivation occurs frequently in different tumor types. However, whether LKB1 associates with the clinical features of gastric cancer (GC) and regulates tumor immunity remains unknown. In this study, we found that LKB1 was highly expressed in the serum of healthy individuals (n = 176) compared with that of GC patients (n = 416), and was also associated with clinical outcomes and good survival rates in GC patients. Furthermore, genes associated with immune checkpoint and T cell activation, such as PD-1, PD-L1, CD8A, CD8B, CD28 and GZMM, were highly expressed in the GC subgroups with high LKB1 expression. Compared with fresh gastric cancerous tissue, LKB1 significantly high expressed in CD3 + CD8 + T cells and CD3 + CD8 + CD28 + T cells in fresh adjacent noncancerous tissues. CD3 + CD8 + T cells produced INF-γ anti-cancer immune response. Furthermore, CD3 + CD8 + T cells proportion which expressed of LKB, showed positive correction with INF-γ expression. Moreover, GC patients with low LKB1 expression showed a poor objective response rate and worse progression free survival and overall survival with pembrolizumab. In conclusion, these results suggest that LKB1 may be a potential immune checkpoint in GC patients.
An unusual case of lower limb dysplasia with ulcer after interventional closure of PDA in childhood
Authors: Li Zizhuo , Xie Ping , Li Jingsong , Xiao Qiuyu , Yang Rui , Deng Yan 
Published: December 2022

Abstract
Background: Lower limb dysplasia is a rare complication after interventional closure of patent ductus arteriosus (PDA) in childhood. The most common treatment of PDA is interventional closure via femoral artery. Compared with traditional surgery, its advantages include less trauma and faster postoperative recovery, but the complications after interventional occlusion should not be ignored.
Case presentation: A 10-year-old girl had redness and swelling of the toes of the right lower limb with skin ulceration on the medial side of the right foot for more than 4 months. She accepted interventional closure of PDA 7 years ago. Physical examination showed that the right foot was about 2 cm shorter than the left foot. We present a rare case of a young girl with lower limb dysplasia after interventional closure of PDA in childhood, Combined findings of Color Doppler ultrasound, Intravenous Ultrasound (IVUS), Computed tomography angiography (CTA) and Angiography, we found right foot developmental delay most likely was due to vascular injury after interventional closure of PDA in childhood.
Conclusion: It is critical to understand not only the acute but also the long-term complications that may occur after interventional procedure. To avoid the development of vascular injury, it is advised that patients who underwent femoral artery catheterization for interventional treatment in their early years undergo strict clinical and imaging surveillance.
Pharmacists’ knowledge, attitudes, practices, and readiness during the COVID-19 epidemic: A cross-sectional study in Baghdad
Authors: Al-Obaidi Mazen M. Jamil , Mahmood Adnan Hussein , Al-Adhamy Mohammed 
Published: December 2022

Abstract
Background
During the COVID-19 pandemic, community pharmacies have been expected to make extraordinary efforts to prevent client cross-infection and to sell masks and disinfectants. Additionally, in most countries, the government might be considered to be responsible for taking the lead in informing the public about the outbreak and associated public health measures. This study aimed to assess Iraqi pharmacists’ knowledge, attitudes, practices, and readiness in relation to COVID-19.
Methods
Seventy pharmacies in Baghdad were randomly visited (from March 20 to May 15, 2020) outside of lockdown hours (9:00 a.m to 12:00 p.m) and had to complete a survey using Google forms following each visit. Descriptive statistical analyses were performed. Numbers and percentages were used to summarize the results.
Results
The Iraqi pharmacists in Baghdad trusted the World Health Organization (WHO), the media, and websites, including Ministry of Health (MOH) websites for COVID-19 information. In terms of COVID-19 treatment, the pharmacists prescribed acetaminophen and corticosteroids. Zinc, vitamin C, and vitamin D were recommended to improve immunity, and these medicines were given orally. Most pharmacists suggested that the call center of the MOH was not answered.
Conclusion
The Iraqi MOH did not include pharmacists in its health emergency preparations, which resulted in a delay in pharmacies’ readiness. National governments and organizations may benefit from using pharmacists’ knowledge and skills to reduce or stop future COVID-19 waves and manage risk if these waves occur.
Scavenger Receptor Class B Type 1 Gene Polymorphism as a Possible Genetic Risk Factor for Insulin resistance
Authors: Himanshu D. , Wamique Mohd , Tamrakar Akhilesh , Ali Wahid , Pandey Sandeep 
Published: December 2022

Abstract
The association between SCARB1 rs74830677 (c.1127 C > T, [P.pro 367 leu] P367L) gene polymorphisms and insulin resistance (IR) has been not been analysed and studied. The clinical relevance of these findings remained uncertain and brings into question the importance of SCARB1 in human physiology. So, we investigated the hypothesis the SCARB1 SNPs in association with the risk of developing insulin resistance. A total of 600 individuals, including 300 T2DM and 300 healthy individuals, were enrolled in the study. Blood samples were collected from each T2DM and healthy individual. CT method for the relative quantitation were used for gene expression level in T2DM and healthy controls. Also, restriction fragment length polymorphism analysis was achieved to detect the incidence of genetic polymorphisms. HOMA resistance index and QUICKI were calculated from fasting plasma glucose and insulin values. In the present study, there was strong association observed between T2DM and SCARB1 rs74830677 gene polymorphism (OR = 1.7, 95% CI 1.18–2.71, P = 0.07). Further, T allele were associated with increase serum insulin and HOMA-IR. Our genotyping data showed that SCARB1 rs7480677 variant is significantly higher in subjects with increased HOMA-IR. Thus, we conclude that SCARB1 polymorphisms may play a crucial role in pathogenesis and susceptibility of insulin resistance thus leads to the development of type 2 diabetes mellitus.
Video foreground and background separation via Gaussian scale mixture and generalized nuclear norm based robust principal component analysis
Authors: Yang Yongpeng , Yang Zhenzhen , Li Jianlin 
Published: December 2022

Abstract
With the rapid development of information technology, the video foreground and background separation has attracted much interests in the computer version. Recently, robust principal component analysis (RPCA) has been widely used in the task of video foreground and background separation. However, the current RPCA methods have more challenge since they are difficult to find the optimal surrogate functions which can describe the sparse and low-rank components of videos very well. This paper proposes a novel RPCA method based on Gaussian scale mixture and general nuclear norm (GSMGNN) to facilitate video foreground and background separation efficiently. In this novel method, we use the Gaussian mixture scale and the nonconvex generalized nuclear norm to describe the sparse foreground and the low-rank background, respectively. Moreover, considering that noise is always existed in the practical scene, we extend the proposed GSMGNN method to the robust Gaussian scale mixture and general nuclear norm (RGSMGNN) method by inducing the noise item. And then, we adopt the efficient alternating direction method of multipliers (ADMM) method to solve these two new proposed methods. At last, we apply these two proposed methods to the video foreground and background separation experiments, and observe their significant encouraging results compared to the existing RPCA-based video foreground and background separation methods.
Quantum ant colony-based mobile-aware service deployment in SDN-based multi- access edge computing environments
Authors: Li Chunlin , Zhang Yong , Luo Youlong 
Published: December 2022

Abstract
With the popularity of emerging mobile services such as virtual reality and online gaming, users are increasingly expecting a higher quality of immersive experience. To address the problems of communication reliability and latency performance between controllers and switches due to single link failures in the network, this paper proposes a reliable placement method for controllers based on deployment cost and link failure probability. A model of reliability and worst-case propagation delay based on link failure probability is constructed, and a controller placement strategy with minimum network cost is solved by a controller placement algorithm based on density-peak clustering. This paper proposes a mobile-aware service adaptive deployment approach to address the problem of long user-perceived latency and high migration costs due to the limitations of edge server resources and coverage areas as well as the dynamic nature of user movement. A mobility model based on the probability density function of sojourn time and a service deployment overhead model based on user mobility are constructed, and the service adaptive deployment scheme is solved by a quantum ant colony algorithm. Experimental results show that the proposed placement algorithm weighs the deployment cost, worst-case propagation delay and reliability of the controllers, and gives a reasonable number of controllers as well as their locations. The proposed deployment algorithm can optimize the quality of user experience.
Bioinformatics Insights on the Physicochemical Properties of SCN5A
Mutant Proteins Associated with the Brugada Syndrome
Authors: Polanco Carlos , Márquez Manlio F. , Uversky Vladimir N. , Lemus Enrique H. , Huberman Alberto , Buhse Thomas , Castro Martha R. 
Published: December 2022

Background:
The Brugada syndrome (BrS) is a heart rhythm condition that is
commonly associated with a strong predisposition for sudden cardiac death. Malignant
ventricular arrhythmias could occur secondary to the dysfunction of the cardiac sodium
voltage-gated Na(v)1.5 channel (SCN5A).

Objective:
This study aimed to perform a multiparametric computational analysis of the
physicochemical properties of SCN5A mutants associated with BrS using a set of bioinformatics
tools.

Methods:
In-house algorithms were calibrated to calculate, in a double-blind test, the Polarity
Index Method (PIM) profile and protein intrinsic disorder predisposition (PIDP)
profile of each sequence, and computer programs specialized in the genomic analysis
were used.

Results:
Specific regularities in the charge/polarity and PIDP profile of the SCN5A mutant
proteins enabled the re-creation of the taxonomy, allowing us to propose a bioinformatics
method that takes advantage of the PIM profile to identify this group of proteins
from their sequence.

Conclusion:
Bioinformatics programs could reproduce characteristic PIM and PIDP profiles
of the BrS-related SCN5A mutant proteins. This information can contribute to a better
understanding of these altered proteins.
Effect of Non-Surgical Periodontal Therapy on Clinical Parameters of
Periodontitis, Oral Candida spp. Count and Lactoferrin and Histatin
Expression in Saliva and Gingival Crevicular Fluid of HIV-Infected Patients
Authors: Nobre Atila V. V. , Polvora Tabata L. S. , Ramos Peña Diana E. , Villafuerte Kelly V. , Silva Gilberto A. , Ranieri Ana Laura P. , de Macedo Leandro D. , Morejon Karen M. L. , da Fonseca Benedito A. L. , Tirapelli Camila , Saraiva Maria C. P. , Pozzetto Bruno , Lourenço Alan G. , Motta Ana Carolina F. 
Published: December 2022

Background:
Periodontitis (PDT) has gained attention in the literature with the increase in life expectancy of people living with HIV on combined antiretroviral therapy (cART). Thus, the search for inflammatory biomarkers could be useful to understand the pathophysiology of chronic oral diseases in the cART era.

Objective:
The aim of this study was to evaluate the impact of non-surgical periodontal therapy (NSPT) on clinical parameters of PDT, Candida spp. count and expression of LF and HST in saliva and CGF of HIV-infected patients.

Methods:
Bleeding index (BI), probing depth (PD), clinical attachment level (CAL), colony-forming units (CFUs) of Candida spp, and lactoferrin (LF) and histatin (HST) levels were measured in saliva and GCF of both groups at three different times: baseline (before treatment), and 30 and 90 days after the NSPT. Clinical, mycological and immunoenzymatic analyses were also performed.

Results:
Twenty-two HIV-infected patients and 25 non-HIV-infected patients with PDT participated in the study. NSPT was effective in improving periodontal clinical parameters, including ≤ 4 sites with PD ≤ 5mm and BI ≤ 10%. No significant change in oral Candida spp. count occurred neither between the two groups nor during the time after the periodontal treatment. And the salivary and GCF levels of LF and HST seems not to be influenced by the NSPT. By contrast, except for salivary LF, HST and LF were shown to exhibit significantly higher levels in HIV-infected than in non-HIV-infected patients.

Conclusions:
NSPT was effective in improving periodontal disease parameters in HIV-infected patients, but do not affect lactoferrin and histatin-5 expression in saliva and ginvival crevicular fluid of HIV-infected patients.
Comprehensive Analysis of VM Migration Trends in Cloud Data Centers
Authors: Singh Shalu , Singh Dinesh 
Published: December 2022

Background:
Virtualization adequately maintains increasing requirements for storage,
networking, servers, and computing in exhaustive cloud data centers (CDC)s. Virtualization assists
in gaining different objectives like dedicated server sustenance, fault tolerance, comprehensive service
availability, and load balancing, by virtual machine (VM) migration. The VM migration process
continuously requires CPU cycles, communication bandwidth, memory, and processing power.
Therefore, it detrimentally prevails over the performance of dynamic applications and cannot be
completely neglected in the synchronous large-scale CDC, explicitly when service level agreement
(SLA) and analytical trade goals are to be defined.

Introduction:
Live VM migration is intermittently adopted as it grants the operational service even
when the migration is executed. Currently, power competence has been identified as the primary
design requirement for the current CDC model. It grows from a single server to numerous data centres
and clouds, which consume an extensive amount of electricity. Consequently, appropriate energy
management techniques are especially important for CDCs.

Method:
This review paper delineates the need for energy efficiency in the CDC, the systematic
mapping of VM migration methods, and research pertinent to it. After that, an analysis of VM migration
techniques, the category of VM migration, duplication, and context-based VM migration is
presented along with its relative analysis.

Results:
The various VM migration techniques were compared on the basis of various performance
measures. The techniques based on duplication and context-based VM migration methods provide
an average reduction in migration time of up to 38.47%, data transfer rate of up to 51.4%, migration
downtime of up to 36.33%, network traffic rate of up to 44% and reduced application efficiency
overhead up to 14.27%.

Conclusion:
The study aids in analyzing threats and research challenges related to VM migration
techniques which ultimately help in exploring future research directions that would help aspiring
cloud professionals.
Simulation Analysis of Stir Tool Wear Considering the Effect of Temperature
Rise caused by Material Deformation on Flow Stress
Authors: Wan Qiang , Xiong Zheng 
Published: December 2022

Background:
Wearing is a prominent problem in friction stir welding. The material flow
stress equation is a key factor that decides the accuracy of the simulation of the wearing process.

Objective:
We aim to propose a material flow stress equation based on material true stress and true
strain curve, which takes proper factors into account and leads to good accuracy in numerical
simulation of stir tool wear.

Methods:
The value of the material temperature rise caused by the material deformation heat and
the value of the effect caused by the temperature rise on flow stress was calculated, and the effect
value was used to modify the material flow stress and the related curve, and then the modified flow
stress equation was obtained. On this basis, the equation was used to simulate the stir tool wear,
and the simulation results were compared with those results without considering the effect of temperature
rise.

Results & Discussion:
the wear amount of the stir needle when considering the effect of temperature
rise is significantly less than that when the effect of temperature rise is not considered.

Conclusion:
In the simulation of the wear of the stir tool, it is necessary to adopt the modified flow
stress equation considering the effect of temperature rise.
Pengaruh pendidikan kewirausahaan di lembaga kursus terhadap sikap berwirasusaha
Authors: Santi Fitta Ummaya , Raharjo Heru 
Published: December 2022

Penelitian ini bertujuan untuk mengetahui pengaruh pendidikan kewirausahaan, efikasi diri dan mindset berwirausaha terhadap sikap berwirausaha peserta didik di lembaga kursus dan pelatihan baik secara sendiri-sendiri maupun secara bersama-sama. Penelitian ini menggunakan metode penelitian kuantitatif. Responden adalah peserta didik Program Pelatihan Kewirausahaan (PKK) tahun 2020 di lembaga kursus dan pelatihan berjumlah 307 orang. Angket disebarkan secara online menggunakan googleform. Analisis data menggunakan analisis regresi dengan bantuan program SPSS 25. Hasil penelitian menujukkan persamaan regresi Y = 6.049 + 0.146 X1 + 0,770 X2 – 0,154 X3 yang artinya pendidikan kewirausahaan di LKP dan efikasi diri berwirausaha berpengaruh secara signifikan terhadap sikap berwirausaha. Sedangkan mindset berwirausaha tidak berpengaruh terhadap sikap berwirausaha. Secara simultan ketiga variabel berpengaruh secara signifikan terhadap sikap berwirausaha.