bluuebunny/crossref_metadata_2025_split huggingface dataset:
Acquired Concurrent EGFR T790M and Driver Gene Resistance From EGFR-TKIs Hampered Osimertinib Efficacy in Advanced Lung Adenocarcinoma: Case Reports
Authors: Zeng Yue , Feng Yuanqing , Fu Guihua , Jiang Junlan , Liu Xiaohan , Pan Yue , Hu Chunhong , Liu Xianling , Wu Fang 
Published: April 2022

The acquired resistance of epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) is inevitable and heterogeneous. The strategies to overcome acquired resistance are significant. For patients with secondary T790M-positive after early generation EGFR-TKIs, osimertinib is the standard second-line therapy. In patients resistant to prior early generation EGFR-TKIs, the acquired T790M mutation overlaps with other driver gene resistance, such as HER2-and MET amplification, accounting for 4–8%. The efficacy of osimertinib is unclear in patients with concurrent multiple driver gene resistance. We here report a patient who acquired EGFR T790M, STRN-ALK fusion, and EGFR amplification after gefitinib progression and subsequent MET amplification acquired from osimertinib. The other patient acquired EGFR T790M and MET amplification post-dacomitinib and acquired CCDC6-RET fusion after osimertinib treatment. Besides, subsequent new bypass activations were the possible resistance mechanisms to second-line osimertinib. Both patients had progression-free survival (PFS) less than 4 months and limited benefits from osimertinib second-line therapy. The T790M accompanying driver gene resistance will be a new subtype after EGFR-TKIs progression, needing effective treatment options.
Clostridium butyricum RH2 Alleviates Chronic Foot Shock Stress-Induced Behavioral Deficits in Rats via PAI-1
Authors: Zhang Wenying , Ding Tingyu , Zhang Hong , Chen Yuping , Liu Liping , Jiang Jinjin , Song Siyuan , Cheng Hao , Wu Changhao , Sun Jihu , Wu Qin 
Published: April 2022

Recent investigations have demonstrated that the chronic stress-induced behavioral disorders can be ameliorated by probiotics including Clostridium butyricum (C. butyricum) via the gut-brain-axis. However, the molecular mechanisms underlying the beneficial effects of C. butyricum on brain remain largely unknown. Here, we investigated whether chronic foot shock stress (CFSS) paradigm used for a hypertensive animal model could induce mood disorders such as anxiety, depression and cognitive impairments. Then, we assessed the impact of C. butyricum RH2 on the behavior disorders and neurobiological alterations in the hippocampus. Male Sprague-Dawley (SD) rats received intermittent electric shocks for consecutive 14 days and were treated with C. butyricum RH2 for 17 days. Anxiety- or depression-like behaviors were evaluated by open field test (OFT), and elevated plus maze (EPM). The Morris water maze test (MWM) was used to evaluate the cognitive functions. CFSS intervention led to mild anxiety- or depression-like behavior or cognitive impairment and C. butyricum RH2 treatment reversed the CFSS-induced symptoms. The serum ACTH or CORT was increased following CFSS but was completely reversed by C. butyricum RH2 treatment. In the hippocampus of CFSS rats, the expressions of BDNF and TrkB were downregulated but proBDNF and P75NTR were upregulated. These expression changes were partially reversed by C. butyricum RH2, suggesting a mode of action on BDNF and proBDNF balance. CFSS exposure resulted in downregulation of tissue-type plasminogen activator (tPA) but upregulation of plasminogen activator inhibitor 1(PAI-1), which could contribute to the decrease in BDNF by reduced conversion from proBDNF to BDNF in the hippocampus. C. butyricum RH2 treatment reversed the upregulated PAI-1 but not the downregulated tPA, which was in parallel with the amelioration of behavioral abnormalities, suggesting a novel tPA independent mechanism for PAI-1 action. Our results demonstrate for the first time that C. butyricum RH2 attenuates stress-induced behavior disorders via inhibiting the expression of brain PAI-1.
The Relationship Between Social Mobility Belief and Learning Engagement in Adolescents: The Role of Achievement Goal Orientation and Psychological Capital
Authors: Xie Jin , Zhang Bo , Yao Zhendong , Peng Biao , Chen Hong , Gao Juan 
Published: April 2022

ObjectiveTo explore the relationship between adolescents’ social mobility belief and their learning engagement, as well as the mediating effect of achievement goal orientation and the moderating effect of psychological capital.MethodA sample of 895 adolescents from Hunan, Jiangxi, Hainan, Henan, and Guangdong provinces were assessed using the social mobility belief questionnaire, the achievement goal orientation questionnaire, the adolescents’ psychological capital questionnaire, and the adolescents’ learning engagement questionnaire.ResultsFirst, adolescents’ social mobility belief was positively related to their learning engagement (r = 0.481, p &lt; 0.01); Second, the two achievement goal orientations-mastery goal orientations and performance goal orientations-had mediating effects between social mobility belief and learning engagement (r = 0.603, p &lt; 0.01; r = 0.367, p &lt; 0.01); Third, the relationship between achievement goal orientation and learning engagement was regulated by psychological capital. Adolescents with high psychological capital had higher learning engagement (r = 0.684, p &lt; 0.01).ConclusionAdolescents’ social mobility belief can directly affect their learning engagement, and it can also indirectly affect their learning engagement through achievement goal orientation moderated by their level of psychological capital. Our findings highlighted the importance of providing adolescents with guidance in setting up positive social values and definitions of success while stimulating their psychological capital as a part of the teaching process.
Working Hours, Sleep Disturbance and Self-Assessed Health in Men and Women: A Multilevel Analysis of 30 Countries in Europe
Authors: Mensah Aziz , Toivanen Susanna , Diewald Martin 
Published: April 2022

ObjectivesThis study examined the gender and cross-country differences in the relationship between working hours and self-assessed health among working men and women in Europe, and further explored the moderating role of sleep disturbance in the relationship.MethodsWe used cross-sectional data from the 6th European Working Condition Survey on 14,603 men and 15,486 women across 30 countries in Europe. A multivariate logistic regression was applied to evaluate the relationship between working hours, sleep disturbance, and self- assessed health. In addition, we employed a two-stage multilevel logistic regression to assess the cross-country variations in the relationship between working hours and self-assessed health.ResultsThe study showed a slightly U-shaped relationship between working hours and less-than-good self-assessed health among working adults in Europe (&lt;31 h: aOR = 1.11; 95% CI: 1.00–1.25, 41–50 h: aOR = 0.98; 95% CI: 0.84–1.15, and 50+ h: aOR = 1.31; 95% CI: 1.07–1.59). However, working men had higher odds of reporting less-than-good self-assessed health as compared to women when they devote longer hours to paid work. The results further showed that there are cross-country variations in the association between working hours and less-than-good self-assessed health for both men and women, and that men had slightly lower variations as compared to women. Contrary to expectation, sleep disturbance did not moderate the relationship between working hours and less-than-good self-assessed health for both men and women in Europe.ConclusionsAlthough there are gender differences and cross-country variations in the association between working hours and less-than-good self-assessed health, sleep disturbance did not moderate the associations. These findings underscore the importance for strict work time regulation and generous work-family policies that may promote good working conditions and health.
Auditory Survey of Endangered Eurasian Bittern Using Microphone Arrays and Robot Audition
Authors: Matsubayashi Shiho , Nakadai Kazuhiro , Suzuki Reiji , Ura Tatsuya , Hasebe Makoto , Okuno Hiroshi G. 
Published: April 2022

Bioacoustics monitoring has become increasingly popular for studying the behavior and ecology of vocalizing birds. This study aims to verify the practical effectiveness of localization technology for auditory monitoring of endangered Eurasian bittern (Botaurus stellaris) which inhabits wetlands in remote areas with thick vegetation. Their crepuscular and highly secretive nature, except during the breeding season when they vocalize advertisement calls, make them difficult to monitor. Because of the increasing rates of habitat loss, surveying accurate numbers and their habitat needs are both important conservation tasks. We investigated the feasibility of localizing their booming calls, at a low frequency range between 100–200 Hz, using microphone arrays and robot audition HARK (Honda Research Institute, Audition for Robots with Kyoto University). We first simulated sound source localization of actual bittern calls for microphone arrays of radii 10 cm, 50 cm, 1 m, and 10 m, under different noise levels. Second, we monitored bitterns in an actual field environment using small microphone arrays (height = 12 cm; width = 8 cm), in the Sarobetsu Mire, Hokkaido Island, Japan. The simulation results showed that the spectral detectability was higher for larger microphone arrays, whereas the temporal detectability was higher for smaller microphone arrays. We identified that false detection in smaller microphone arrays, which was coincidentally generated in the calculation proximate to the transfer function for the opposite side. Despite technical limitations, we successfully localized booming calls of at least two males in a reverberant wetland, surrounded by thick vegetation and riparian trees. This study is the first case of localizing such rare birds using small-sized microphone arrays in the field, thereby presenting how this technology could contribute to auditory surveys of population numbers, behaviors, and microhabitat selection, all of which are difficult to investigate using other observation methods. This methodology is not only useful for the better understanding of bitterns, but it can also be extended to investigate other rare nocturnal birds with low-frequency vocalizations, without direct ringing or tagging. Our results also suggest a future necessity for a robust localization system to avoid reverberation and echoing in the field, resulting in the false detection of the target birds.
Which Role for Hyperbaric Oxygen Therapy in the Treatment of Fournier's Gangrene? A Retrospective Study
Authors: Tutino Roberta , Colli Francesco , Rizzo Giovanna , Bonventre Sebastiano , Scerrino Gregorio , Salamone Giuseppe , Melfa Giuseppina , Orlando Giuseppina , Gallo Gaetano , Santarelli Mauro , Massani Marco , Cocorullo Gianfranco 
Published: April 2022

PurposeIn Fournier's gangrene, surgical debridement plus antimicrobial therapy is the mainstay of treatment but can cause a great loss of tissue. The disease needs long hospital stays and, despite all, has a high mortality rate. The aim of our study is to investigate if factors, such as hyperbaric therapy, can offer an improvement in prognosis.MethodsWe retrospectively evaluated data on 23 consecutive patients admitted for Fournier's gangrene at the University Hospital “P. Giaccone” of Palermo from 2011 to 2018. Factors related to length of hospital stay and mortality were examined.ResultsMortality occurred in three patients (13.1%) and was correlated with the delay between admission and surgical operation [1.7 days (C.I. 0.9–3.5) in patients who survived vs. 6.8 days (C.I. 3.5–13.4) in patients who died (p = 0.001)]. Hospital stay was longer in patients treated with hyperbaric oxygen therapy [mean 11 (C.I. 0.50–21.89) vs. mean 25 (C.I. 18.02–31.97); p = 0.02] without an improvement in survival (p = 1.00).ConclusionOur study proves that a delay in the treatment of patients with Fournier's gangrene has a correlation with the mortality rate, while the use of hyperbaric oxygen therapy seems to not improve the survival rate, increasing the hospital stay instead.
Inter-arm blood pressure difference and cardiovascular risk estimation in primary care: a pilot study
Authors: McDonagh Sinead T J , Norris Ben , Fordham A Jayne , Greenwood Maria R , Richards Suzanne H , Campbell John L , Clark Christopher E 
Published: April 2022

BackgroundSystolic inter-arm differences (IAD) in blood pressure (BP) contribute independently to cardiovascular risk estimates. This can be used to refine predicted risk and guide personalised interventions.AimTo model the effect of accounting for IAD in cardiovascular risk estimation in a primary care population free of pre-existing cardiovascular disease.Design & settingA cross-sectional analysis of people aged 40–75 years attending NHS Health Checks in one general practice in England.MethodSimultaneous bilateral BP measurements were made during health checks. QRISK2, atherosclerotic cardiovascular disease (ASCVD), and Framingham cardiovascular risk scores were calculated before and after adjustment for IAD using previously published hazard ratios. Reclassification across guideline-recommended intervention thresholds was analysed.ResultsData for 334 participants were analysed. Mean (standard deviation) QRISK2, ASCVD, and Framingham scores were 8.0 (6.9), 6.9 (6.5), and 10.7 (8.1), respectively, rising to 8.9 (7.7), 7.1 (6.7), and 11.2 (8.5) after adjustment for IAD. Thirteen (3.9%) participants were reclassified from below to above the 10% QRISK2 threshold, three (0.9%) for the ASCVD 10% threshold, and nine (2.7%) for the Framingham 15% threshold.ConclusionKnowledge of IAD can be used to refine cardiovascular risk estimates in primary care. By accounting for IAD, recommendations of interventions for primary prevention of cardiovascular disease can be personalised and treatment offered to those at greater than average risk. When assessing elevated clinic BP readings, both arms should be measured to allow fuller estimation of cardiovascular risk.
Textes pour l’identité alsacienne. Objet-méthode-perspective
Authors: Cerf Eve 
Published: April 2022

Texte für die elsässische Identität. Gegenstand, Methode, Perspektiven

Die Texte, die die elsässische Identität bekräftigen sollen, zeichnen sich durch strukturelle und semantische Einheitlichkeit aus. Ihre formale Unterschiedlichkeit entspricht dabei der Anpassung des Shines an den jeweiligen politischen und gesellschaftlichen Kontext.
Die elsässischen Texte beinhalten eine eschatologische Sicht von der Zeit, dem Tod und den Modellen zur Lösung existentieller Probleme. Ihre Botschaft, die Gefühle der Zugehörigkeit und der Ablehnung als Antwort hervorruft, begünstigt das Entstehen einer allen Elsässem gemeinsamen Identität und erlaubt zugleich, den Gegner lächerlich zu machen. Eine Provinz, deren nationale, sprachliche und kulturelle Bindungen in regelmäßigen Zeitabständen in Frage gestellt wurden, kämpft gegen die Assimilation an, indem sie zu den Mitteln des Spottes greift, ohne dabei jedoch Haßgefühle zu erwecken.
Crise régionale et question du logement en Lorraine sidérurgique
Authors: Rocher André , Woehl Bernard 
Published: April 2022

Regional crisis and housing question.
The object of this contribution is to call attention to the existing relation between the housing question in iron and steel producing Lorraine and the crises that this industry and region are at present undergoing. The former solidarities, the new institutional geography brought about by recent government reforms, and notably decentralization and the various nationalizations are put in perspective through an examination of the housing question.
L’espace cultivé dans une vallée vosgienne (la vallée de la Plaine) : approche ethnologique du «sauvage» et du «cultivé»
Authors: Méchin Colette , Schaal Benoist 
Published: April 2022

Der bebaute raum in einem vogesental («vallée de la plaine») : ethnologische befassung des «wilden» und des «bebauten».
Im Rahmen einer breiten Untersuchung welche an die Wahmehmung der Tiere und der Pflanzen bei den Einwohnern eines Vogesentals — vallée de la Plaine — interessiert (diese Untersuchung ist vom Kulturministerium subventioniert), war es uns nötig, uns die Frage zu stellen, wie die Wilden und die domestizierten Pflanzen sich in dem Bedenbausystem ineinanderfügen. Damit mußten wir zuerst die bäuerliche Landschaft wiederherstellen, wie sie vor fünfzig Jahren aussah, um die Einrichtung des Ackerlands und den Gedanke der Bauern zu verstehen.
Méthode de recueil et d’analyse pour une nouvelle mythologie alsacienne
Authors: Groshens Marie-Claude 
Published: April 2022

Sammlungs und analysemethode für eine neue elsässische mythology.
Das Studium der Mythology und der volkstümlichen Literatur des Elsasses bringt spezifische Probleme mit sich, welche mit der Verstädterung und der frühen Alphabetisierung des Elsasses zusammenhängen. Neben einer volkstümlichen Literatur, welche die Errungenschaften der stadtischen Freiheiten preist den frühen Aufstieg der Stadte und der bürgerlichen Lebensweise überhaupt, bestehen sehr zahlreiche Erzahlungen, die meist entfernten Tälern entstammen. Das Sammeln und Analysieren dieser Texte ist heitel, denn trotz grosser Entfernung von den Stadten ist deren literarischer Einfluss dentlich darin Spürbar.
Les coiffes dans le Pays de Wissembourg
Authors: Delrœux Marie-Clotilde 
Published: April 2022

Die hauben im weißenburgerland.
In der Tracht beteiligt sich die Haube, zuerst an die Erkennung der Persôn-lichkeit durch die Gesellschaft und das Weißengurgerland macht nicht Außnahme an der Ordnung. Die Suzammenstellung Haube-Frisur bringt genügende Außkünfte damit jeden Mietglieder von den verschiedenen Gemeindschaften, die das «Gesetz» kennen, die Person erkennt. Wenn die biologische, familie, religiose Hinweisungen symbolisiert auf der Haube merken sich das ganzen Jahr entlang und nach die Handlungen der Woche oder dem Sonntag, sind die Frauenhauben die spitzfindigsten Trägerinnen.
Essai d’anthropologie de l’alimentation dans le Nord-Est français. Première partie : usages vosgiens
Authors: Méchin Colette 
Published: April 2022

Essay einer Enährungsanthropologie in nord-ost frankreich
Erstes teil : Vogesenbrauchtum

In der Absicht eine Serie Bilder der Nahrungs-verhalten bei den Einwohnern N-0 Frankreich zusammenzustellen, will dieser erster Artikel das Brauchtum der Vogesenleuten analysieren. Die Küchegrundlagen sind allso registriert, so wie der Platz der jede Speise in der Ernahrung halt : Kohlgemüse und Schweinefleisch, Kartoffeln und Milchkost. Daraus bemerkt man schnell die Vorliebe für Topfkochen, Und weiter skizziert sich eine Gaschmack - und Farbentypologie : sauer und salzig fügen sich mit verschiedenen Speisenfarben ineinander ; und, ursprunglich Oder erzeugt, werden dieser Farben nach die Speisen eben mehr oder weniger geschätzt.
Mémoires du textile dans une vallée vosgienne en crise
Authors: Herberich-Marx Geneviève , Jonas Emmy , Raphaël Freddy 
Published: April 2022

Wachrufung von Erinnerun-gen der Textilproduktion in einem Vogesental im Krisen-zustand.

Im markircher Tal, aus dem sich das Leben zurück zu ziehen scheint, iiber-reizt sich, im Gegensatz, die Gedächtnisarbeit bei den Alten, als drängte es, Angesichts der eingestürzten Dâcher, den leeren Werkstätten, den oft schläfrigen Strassen, Zeugnis abzulegen über die frühere Aktivität und Geselligkeit. Wie eine befehlende Notwendigkeit, drängt die Textilkrise die Altarbeiter zur Nennung und Behauptung der Identitat einer Ortschaft die über allem eine Arbeits - und Lebensgemeinschaft darstellte.
Die Hauptkraftlinien für die sich das Gesichtsfeld des «Textilgedächtnisses» in einer neuen Dynamik bildet, erschien allmählich während der Alalyse der verschiedenen eingezogenen Erkundigungen. Entsprechend und aufeinan-derfolgend zu bearbeiten sind also :
-Wachrufung der Erinnerung an die «markircher Produkte» als Empfehlungssinnbild in dem Mythos und Wirklichkeit ineinanderfliessen,
-Hinweise zum Wissen und Können das eine der Quellen der Arbeiterwürde darstellt, und, manchmal gegensàtzlich, das gegenwärtige Minderwertigkeitsgefühl wegen der heutigen Disqualifizierung,
-Verherrlichung der früheren Geselligkeit auf dem Arbeitsplatz wie auch im gesellschaftlichen Zusammenleben, und somit die darausfolgende Versch-leierung von Zwiespalt und Handel,
-Zuletzt, Erwähnung herausstechen-der Ereignisse seit der Volksfront (Front Populaire), des zweiten Weltk-riegs, bis zur Nachwirkung der Krise und der Betriebsstillegungen.
Damit zeichnen sich die Richtlinien um die sich ein gemeinsames, manigfaltiges Gedàchtnis prägt, dessen Ursprung sich im Zusammenbruch einer Seinsweise findet, der wie ein Ausschliessungspro-zess erlebt wird.
«D’r Hans im Schnokeloch». Un mythe transitionnel entre la France et l’Allemagne
Authors: Cerf Eve 
Published: April 2022

«Hans im Schnokeloch».
The new Alsatian myth of «Hans im Schnokeloch» John in his Mosquito Hole, developed contrapuntally to the old myth of the radiant young girl. The study of «Hans im Schnokeloch» reveals that throughout specific periods in histoiy, this myth has constituted a form of answer to underlying social contradictions.
The old myth of the radiant young girl and the new myth of «Hans im Schnokeloch» disappeared in the aftermath of the last Worl War, following the changes undergone by society and the end of the on-going Franco-German warring context.
Les Personnes Handicapées. De la recherche d’une identité à l’attribution d’un statut, l’intégration et ses ambiguïtés
Authors: Lehmann René , Brablin Pierre 
Published: April 2022

The integration and its ambiguity.
The law N° 75-734 of 30 june 1975 relating to social aid for handicapped people recognises specific rights for a given population. A policy has been laid down. The aim is to increase financial aid «in favour of» handicapped people ant do spread equitably these «socialtransfers ».
The needs of the physically handicapped are firstly financial but also care, limbfitting, technical aids, transport, housing, education and indépendance. Several Ministeries concerned with the handicapped and their problems take part in this «national obligation» of aid.
The aim of all parties is to transform the environment, to reduce the handicap by all means possible. The hope and expectation of handicapped people lies in «access to an open social space». What is at stake is : the recovery of human dignity, an identity of «persona grata», their place in the family, astatus of active members of society.
Les enfants de l’oubli
Authors: Cerf Eve 
Published: April 2022

The forgotten Children.
Studying the case of Jewish children isolated in the aftermath of World War II leads us to redefine the notion of «survivors» and to analyse the symbolism of death and the impact of mass murder on the survivors and their descendants.
The example of Jewish children adopted after the War enables us to demonstrate the implications of name changing and the late adoption of children who have suffered massive psychical traumas.
La chimie des frontières. Rejets et débris voyageurs (18 -20e siècles)
Authors: Dubinsky-Titz Monique 
Published: April 2022

Chemistry of Border-Zones : refuse and waste, from the 18th to the 20th century.
In the 18th centuiy, the odours of refuse-dumps, foul-smelling rivers, and graveyards are unpleasant and alarming. People start suspecting that this state of things could be related to the outbreak of epidemics.
Thus, all the objects which seem threatening in the immediate vicinity are removed further away. Great spaces are cleared, where the by-products of life and human activity can be dumped. But at the end of the 20th century, there is no longer any possibility to dump refuse «elsewhere». Chemical stenches caused by production, the piling-up and incineration of waste, give birth to protest and opposition : it is once again hard to make out what is due to sensation from what is really toxic. On the border-zones, fears are more insistent, because these areas reveal a new form of intolerance.