bluuebunny/crossref_metadata_2025_split huggingface dataset:
Optimising medical retrieval processes and outcomes in remote areas in high‐income countries: A scoping review
Authors: Mathew Supriya , Russell Deborah J. , Fitts Michelle S. , Wakerman John , Honan Bridget , Johnson Richard , Zhao Yuejen , Reeve David , Niclasen Petra 
Published: July 2022

AbstractObjectiveThis scoping review explores the structure and process‐level strategies that are associated with medical retrieval outcomes. A secondary aim is to identify the range of medical retrieval outcomes used to assess the performance of remote retrieval services.DesignA scoping review of peer‐reviewed literature from PubMed, CINAHL and the Web of Science was undertaken following guidelines set by the Johanna Briggs Institute manual for scoping reviews. All articles were assessed by two reviewers. Themes were derived inductively from the data extracted.SettingMedical retrievals in sparsely populated remote locations in high‐income countries.ParticipantsStaff and clients of remote medical retrieval services.InterventionsStructures and processes (e.g. resource availability, retrieval staff structures and governance protocols) that aimed to improve medical retrieval outcomes.OutcomesPatient health outcomes and service efficiency.ResultsTwenty‐four articles were included. Three broad themes, related to the nature of the interventions, were included: optimising prehospital management of retrievals, staffing and resourcing of retrieval services and retrieval model evaluation. Mortality was the most frequently used outcome indicator in these studies, but was not measured consistently across studies.ConclusionsThis review highlights significant gaps in the literature that describes the structure and processes of retrieval models operating in remote areas and a dearth of literature evaluating specific operational strategies implemented within medical retrieval models. The available literature does not meaningfully assist with identifying key outcome indicators for developing a consistent monitoring and evaluation framework for retrieval services in geographically, culturally and demographically diverse remote contexts.
Estimating sediment transport diffusion coefficients from reconstructed rifted margin architecture: measurements in the Ogooué and Zambezi deltas
Authors: Simon Brendan , Robin Cécile , Rouby Delphine , Braun Jean , Guillocheau François 
Published: July 2022

AbstractDiffusion‐based stratigraphic models are widely used to simulate sedimentary systems and margin deltas. Diffusion‐based models assume that the topographic evolution primarily depends from its slope. Limited attention has however been given to the calibration of the transport coefficients. Here, we evaluate transport coefficient values from natural examples, the Ogooué and Zambezi rifted margin deltas over the last 5 to 12 Ma respectively. We developed a method to estimate transport coefficients based on high resolution seismic stratigraphy analysis of the stratigraphic architecture of these deltas. For each stratigraphic sequence, we calibrated the sand/shale ratios of the deposits, we restored their depositional slopes, we estimated their uncompacted accumulated volumes and we calculated the transport coefficient (Kd) from the sediment flux/slope ratio. Estimated values of Kd fall within one order of magnitude (×0.1 km2/ka), a much narrower range than previously published values (×0.0001 to ×100 km2/ka). We show that the diffusion approximation is optimal at 10–100 km scale and 0.5–1 Ma time resolution, independently of the stratigraphic context. We show that the diffusion assumption is appropriate for the formation of the clinoforms (mainly gravity driven). It is however not optimal for the shelf and distal domains where additional processes (e.g., wave, flood, hemipelagic, turbidites, oceanic current), not accounted for it the diffusion assumption, significantly impact sediment transport. We documented a significant increase of Kd values after 0.9 Ma, coeval of an increase in the amplitude of eustatic variations at this time indicating that the calibration of Kd from present day sedimentary systems might not be optimal for simulations of sedimentary systems before the last million years.
Elicitors and phenotypes of adult patients with proven IgE‐mediated food allergy and non‐immune‐mediated food hypersensitivity to food additives
Authors: Alexiou Aikaterina , Höfer Veronika , Dölle‐Bierke Sabine , Grünhagen Josefine , Zuberbier Torsten , Worm Margitta 
Published: July 2022

AbstractBackgroundFood allergy is a growing health concern with a prevalence of 2%–3% in the adult population in Europe. Non‐immune‐mediated food hypersensitivities, which include reactions after ingestion of food additives, affect 1% of adults and may resemble IgE‐induced allergic reactions without identifiable immunologic sensitization. A double‐blind placebo‐controlled food challenge (DBPCFC) is the gold standard for the diagnosis of any food hypersensitivity.ObjectiveWe analysed a large group of adult patients with suspected food hypersensitivity, who had undergone DBPCFC, to better understand IgE‐mediated food allergy and non‐immune‐dependent food hypersensitivity to food additives in adults regarding elicitors, symptoms and positivity rates of oral challenges.MethodsData from 541 patients with suspected food hypersensitivity were analysed, who underwent an oral food challenge between 2010 and 2019.ResultsIgE‐dependent food allergy was confirmed in 114 of 329 adult patients (34.6%). The confirmation rate was lower in the group of patients with suspected non‐immune‐mediated reactions to food additives (65 of 286, 22.7%). Urticaria and angioedema appeared more frequently in patients with IgE‐mediated food allergies. By contrast, flush and diarrhoea were the most frequent symptoms after a challenge in the group with the non‐immune‐mediated reactions to food additives. Wheat and celery were the most frequently identified food allergens in adults, whereas colourings and preservatives were the most frequent elicitors of non‐immune‐mediated food hypersensitivity.ConclusionThe importance of oral food challenges for the diagnosis of food hypersensitivity is confirmed. IgE‐dependent food allergy is more frequently proven, reaching a positivity rate of one‐third and only about 20% for non‐immune‐mediated hypersensitivity. Future studies should elaborate on the mechanisms of non‐immune‐mediated food hypersensitivity and the clinical impact of cofactors in this setting.
Measurement of ANP, BNP and endothelin‐1 concentrations in jumping horses with heart valvular regurgitation and their correlation with the dimensions of heart structures
Authors: Sadeghian Chaleshtori Sirous , Mokhber Dezfouli Mohammad Reza , Najizadeh Mohammad Hassan , Nikbakht Borujeni Golam Reza 
Published: July 2022

SummaryBackgroundNatriuretic peptides and endothelin‐1 are used as biochemical biomarkers for the diagnosis and prognosis of heart diseases.ObjectivesThis study aimed to investigate plasma ANP, BNP and endothelin‐1 in jumping horses with various manifestations of heart valve regurgitation and their association with echocardiographic variables.Study designClinical evaluations including cardiac auscultation were performed in 198 jumping horses, and 30 horses were chosen.MethodsSixteen jumping horses with murmurs of grade 3/6 to 5/6 having various degrees of heart valve regurgitation with the severity of insignificant to moderate on colour Doppler echocardiography were considered as the valvular regurgitation group (average age 9.75 ± 3.28 years and weight 427.43 ± 82.22 kg, and consisting of 10 mares, three stallions and three castrated male horses with breeds of 12 Thoroughbred and four crossbred). Fourteen healthy horses were chosen as the healthy group (average age 8.64 ± 2.44 years and weight 462.14 ± 77.42 kg, and consisting of nine mares, three stallions and two castrated males with breeds of 12 Thoroughbreds, and two crossbred). Blood samples were collected from the jugular vein, and plasma concentration of ANP, BNP and endothelin‐1 was determined using Sandwich ELISA by a horse‐specific kit. Then, the plasma concentration of mentioned peptides and echocardiographic variables were compared between the two groups.ResultsB‐type natriuretic peptide was significantly increased in horses with valve regurgitation compared to healthy horses, but increases in ANP and endothelin‐1 were insignificant. Also, in the valvular regurgitation group, horses with a pulmonic valve disorder had a significantly higher concentration of BNP and endothelin‐1 than healthy horses. Assessment of the relation between ANP, BNP and endothelin‐1 with echocardiographic variables showed a significant correlation between ANP and right ventricle length (RVL) and left ventricle width (LVW) in systole and endothelin‐1 with right ventricle width (RVW) and left ventricle width in systole, but BNP had no significant correlation.Conclusion and clinical importanceAccording to the study results, it can be assumed that the measurement of these cardiac biomarkers can be helpful in the diagnosis of the jumping horse with cardiac valvular disorders (especially pulmonic valve regurgitation) and changes in the dimensions of the heart ventricle.
Postural orthostatic tachycardia syndrome and migraine: A narrative review
Authors: Mueller Bridget R. , Robinson‐Papp Jessica 
Published: July 2022

AbstractObjectiveIn this narrative review, we summarize experimental and clinical evidence demonstrating mechanistic connections between POTS and migraine.BackgroundMigraine is the most common comorbidity in patients with POTS, a heterogenous disorder of the autonomic nervous system characterized by orthostatic intolerance and positional tachycardia. POTS is a debilitating illness with few effective treatments. We aim for this narrative review to increase awareness of the mechanistic connections between POTS and migraine providing foundational information that optimizes clinical care and advances the development of pathophysiologic‐based treatments.MethodsWe used the PubMed and Medline databases in November 2021 to perform a literature review and searched for the following keywords: “postural orthostatic tachycardia syndrome,” “POTS,” “autonomic nervous system,” AND “migraine,” “headache.”ResultsThe high prevalence of migraine in patients with POTS may be explained by common pathologic mechanisms. There is evidence that dysregulation of the sympathetic nervous system, alterations in central and peripheral hemodynamics, and central sensitization increase vulnerability to both POTS and migraine. Non‐pharmacologic and pharmacologic treatments that target these shared mechanisms may provide significant benefit for the patient with POTS and migraine.ConclusionsIdentification of common affected pathways may provide important insight that advances our understanding and treatment of both migraine and POTS.
Diet restriction alone improves glucose tolerance and insulin sensitivity than its coadministration with krill or fish oil in a rabbit model of castration‐induced obesity
Authors: Grigorova Natalia , Ivanova Zhenya , Bjørndal Bodil , Berge Rolf Kristian , Vachkova Ekaterina , Milanova Aneliya , Penchev Georgi , Georgiev Ivan Penchev 
Published: July 2022

AbstractThis study investigated the effect of 50% diet restriction and its coadministration with krill oil (KO) or fish oil (FO) on glucose tolerance and insulin sensitivity in a rabbit model of obesity. Castrated male rabbits were 50% restricted fed and supplemented with KO or FO (600 mg omega‐3 polyunsaturated fatty acids/daily) for 2 months. Simultaneously, two control groups were used: castrated, full‐diet‐fed and castrated, 50% restricted fed rabbits without additives restricted group (RG). The energy‐restricted diet decreased final body weight in castrated male rabbits and improved most insulin sensitivity and β‐cell function indexes. Combining the same diet and KO or FO, further reduced fasting blood glucose levels. However, this feed regime significantly accelerated insulin secretion and reduced gene expression of insulin receptor substrate‐1, pyruvate kinase and 3‐hydroxy‐3‐methylglutaryl‐CoA synthase 2. This was manifested by reduced dynamic insulin sensitivity, assessment homoeostasis‐β‐cell function indices and increased glucose elimination rate to levels comparable to or above the obese animals. Aspartate and alanine aminotransferases enzyme activities were raised more than those in the obese group. Surprisingly, KO and FO administration downregulated acetyl‐coenzyme A oxidase and carnitine palmitoyltransferase 2 messenger RNA gene expression compared to the RG. In conclusion, we can assume that a better effect on insulin sensitivity and glucose tolerance was observed in the diet restriction alone than in the coadministration of KO or FO when animals are exposed to highly obesity predisposing factors. These effects could be at least in part ascribed to the modified gene expression levels of some critical enzymes and factors involved in liver glucose metabolism and β‐oxidation.
Influence of refeeding on production, blood biochemistry parameters, and reproduction in underfed Kacang goat does
Authors: Widiyono Irkham , Yanuartono Yanuartono , Purnamaningsih Hary , Sarmin Sarmin 
Published: July 2022

AbstractThis research aimed to investigate the effect of refeeding on production, blood biochemical parameters, and reproduction in underfed Kacang goat does. Twelve 2–3‐year‐old Kacang goats scored (body condition score [BCS]: 1–1.5) with poor body condition but appeared healthy, gave normal births 3–4 months before but no longer nursing their youngs, and anestrus were used in this study. The experiment consisted of 110 days with 14 days of adaptation period and 96 days of feeding treatment and data collection. After the adaptation period, the animals were divided into two groups (A and B), with six animals each. During the first 40 days (underfeeding period), they were fed with kangkong (Ipomoea reptans) straw at a level of 2% of body weight (BW). For the following 56 days (refeeding period), each animal in group A was fed at the level of 4% BW per day while group B was fed at the level of 5% BW per day consisting of 50% kangkong straw and 50% concentrate. Feed intake, average daily gain, body condition, and estrus were assessed in the period of underfeeding and refeeding. Blood samples were collected at the end of the underfeeding and refeeding period for blood biochemical parameter analyses. During the underfeeding period, the animals were anestrous and had poor body condition (BCS: 1.17–1.33) and high serum levels of cortisol, progesterone, and estradiol. Refeeding resulted in a significant increase in BCS (2.75–3.0), restoring estrous cycle, and reduced serum cortisol and progesterone level (p < 0.05). The Kacang goats had good compensatory growth. It could be concluded that refeeding at the level of 4–5% BW would restore undernourished goats' clinical condition, productivity, and reproductive performance after 8 weeks of refeeding.
Reflecting back to move forward: Lessons learned about COVID‐19 safety protocols from pediatric anesthesiologists
Authors: Vigouroux Marie , Amja Kristina , Bertolizio Gianluca , Ingelmo Pablo , Hovey Richard 
Published: July 2022

AbstractBackgroundThe COVID‐19 pandemic brought about the immediate need for enhanced safety protocols in health care centers. These protocols had to evolve as knowledge and understanding of the disease quickly broadened.AimsThrough this study, the researchers aimed to understand the experiences of pediatric anesthesiologists at the Montreal Children's Hospital and the Shriners' Hospital Canada as they navigated the first wave of COVID‐19 at their institutions.MethodsNine participants from the Montreal Children's Hospital and the Shriners' Hospital were interviewed. Interviews were recorded, transcribed verbatim, and then analyzed using an applied philosophical hermeneutics approach.FindingsParticipants expressed their wish for simple and easy‐to‐apply protocols while recognizing the challenge of keeping up with evolving knowledge on the disease and its transmission. They pointed to some limitations and unintended consequences of the safety protocols and the system‐wide flaws that the COVID‐19 pandemic helped bring to light. They described their frustrations with some aspects of the safety protocols, which they at times felt could be more efficient or better suited for their daily practice.ConclusionsThe findings of this study highlighted the importance of listening to and empowering anesthesiology staff working in the field during crises, the implications of shifting from patient‐centered care to community‐centered care, and the fine line between sharing as much emerging information as possible and overwhelming staff with information.
Cross‐industry interlinkages in employment growth: Evidence from Brazil
Authors: Carvalho Daniel R. , Lee Jean N. 
Published: July 2022

AbstractUsing establishment‐level data from Brazil, we estimate the extent to which firm‐ and industry‐level employment and entry decisions respond to changes in the employment decisions of geographically proximate firms and industries. We instrument for employment changes by following Bartik (1991) and Blanchard and Katz (1992). Our analysis suggests the existence of economically and statistically significant effects of municipality‐level shocks in other industries on the employment and entry decisions of firms and industries in the same municipality. Spillovers are heterogeneous across municipalities and vary based on municipality income, distance from regional economic centers, and transport costs.
Automated closed volume reduction process for apheresis stem cell grafts: From development to clinical implementation
Authors: Howell Anita , Letcher Brenda , Murphy Kelly , Elmoazzen Heidi , Petraszko Tanya , Acker Jason P. , Pineault Nicolas , Holovati Jelena L. 
Published: July 2022

AbstractBackgroundCollection of HPC by apheresis (HPC‐A) can sometimes result in higher collection volumes, increasing the dimethyl sulfoxide (DMSO) volume infused into patients and the space requirements in liquid nitrogen freezers. Volume reduction prior to the addition of cryoprotectant is an efficient means to reduce the DMSO load infused into patients and to optimize freezer storage space.Study Design and MethodsTo implement a closed semi‐automated volume reduction process, a method was developed to produce leukocyte‐rich mock apheresis products using buffy coats derived from whole blood collections. The mock HPC products were then used to measure the efficiency and reliability of the semi‐automated process over a range of volumes and cell concentrations. The resulting data was used to support the implementation of the process with concurrent monitoring.ResultsA closed, semi‐automated volume reduction process resulted in recoveries of over 93% and 91% of white blood cells and CD34+ cells with no significant loss of product viability or potency. Mean doses of CD34+ and CFU infused per kilogram recipient body weight were 4.0 ± 1.1 × 106/kg and 4.2 ± 1.7 × 105/kg, resulting in no delays in median time to neutrophil and platelet engraftment, significant increase in adverse reaction or nonconformances.DiscussionThe effectiveness outcomes of the first Canadian experience in the implementation of a closed semi‐automated volume reduction system in the processing of HPC‐A products for autologous transplant have met the predetermined acceptance criteria, supporting its use in a stem cell manufacturing laboratory compliant with good manufacturing practice regulations.
Minimum Quantity Cutting Fluid Application for Grinding Weld Flash: Surface Integrity Evaluation
Authors: Rangasamy Nithin , Rakurty Chandra Sekhar , Maurer Zach 
Published: July 2022

Abstract
The effect of the grinding process for weld flash removal on the surface integrity of the welded joint has not been researched. The surface integrity of the welded joint is essential for the bandsaw blade life and to prevent any premature failure at the weld joint due to fatigue loading (a band saw blade undergoes mainly cyclic bending fatigue during its service). In this study, the effects of using different cutting fluid combinations on the grinding of weld flash in medium carbon alloy steel were carried out. The use of compressed air (CA) as a sustainable solution for grinding weld flash was explored. An experimental investigation of four different cutting fluid applications (dry/no cutting fluid, compressed air, minimum quantity lubricant using vegetable oil, and minimum quantity coolant using water-soluble oil) was carried out. The surface roughness, sub-surface residual stresses, and microhardness of the ground region were measured. This is a first-of-the-kind study on the effect of the flash removal process on the surface integrity of the welded joint. The results show that the surface integrity of the welded joint is significantly influenced by the cutting fluid application used during the grinding process of the flash. Dry grinding, the current industry standard for grinding weld flash in band saw blades, produced surface tensile residual stresses (24.82 MPa), lowest sub-surface microhardness (43.28 HRc), and the highest surface roughness (3.40 µm). In comparison, the air application had the highest surface compressive residual stresses (−289.57 MPa), highest sub-surface microhardness (48.67 HRc), and relatively low surface roughness (1.61 µm). This study provides the road map for selecting the cutting fluid application for grinding weld flash produced by the resistance welding process in the band sawing industry.
Incidence, progression and regression of diabetic retinopathy in a northeastern Chinese population
Authors: Lin Zhong , Wen Liang , Wang Yu , Li Dong , Zhai Gang , Moonasar Nived , Wang Fenghua , Liang Yuanbo 
Published: July 2022

AimTo determine the incidence, progression and regression of diabetic retinopathy (DR), with corresponding risk factors, in a northeastern Chinese population of patients with type 2 diabetes.MethodsAmong 2006 patients who completed baseline examinations in 2012–2013 and underwent re-examination after a mean interval of 21.2 months, 1392 patients with gradable fundus photographs for both baseline and follow-up examinations were included. Incidence was defined as new development of any DR among patients without DR at baseline. An increase of ≥2 scales (concatenating Early Treatment Diabetic Retinopathy Study levels of both eyes) in eyes with DR at baseline was defined as progression, while a reduction of ≥2 scales was defined as regression.ResultsThe age- and sex-standardised incidence, progression and regression were 5.8% (95% CI 4.7% to 6.9%), 26.8% (95% CI 24.8% to 28.8%) and 10.0% (95% CI 8.6% to 11.3%), respectively. In addition to poor blood glucose control, wider central retinal venular equivalent was associated with both incidence (relative risk (RR) 2.17, 95% CI 1.09 to 4.32, for ≥250 µm vs <210 µm) and progression (RR 2.00, 95% CI 1.02 to 3.96, for ≥250 µm vs <210 µm). Patients without insulin therapy (RR 0.64, 95% CI 0.43 to 0.97) and patients with wider central retinal arteriolar equivalent (RR 1.14, 95% CI 1.02 to 1.26, per 10 µm increase) were likely to exhibit DR regression.ConclusionWe determined the incidence, progression and regression of DR among northeastern Chinese patients with type 2 diabetes. Retinal vessel diameters, in addition to blood glucose level, influence the natural evolution of DR.