bluuebunny/crossref_metadata_2025_split huggingface dataset:
Early versus late body condition score loss in dairy cows: Reproductive performance
Authors: Pfeifer Luiz , de Lima Rhuan Amorim , Nakashima Sidnei , Silva Jackeline Thaís da , Schmitt Eduardo 
Published: September 2022

Abstract
This study aimed to compare milk production and reproductive performance in high yield Holstein cows that lose BCS early and late in the postpartum period. Lactating dairy cows (n = 76) were received first timed AI at 60 to 75 DIM using the farm-managed estradiol-progesterone-GnRH based timed AI protocol. The BCS of all cows was daily evaluated by automated BCS cameras. Aiming to evaluate the effect of the days in milk (DIM) in which a cow reached the nadir BCS on the reproductive parameters, cows were separated into two groups: Early BCS loss (n = 42), cows that reached the nadir BCS ≤ 34 DIM, and Late BCS loss (n = 34), cows that reached the nadir BCS > 34 DIM. The optimal cut-off point for determining the relationship between days to nadir BCS and pregnancy by 150 DIM (P150) was calculated using the receiver operating characteristic (ROC) curve. From the ROC analysis the cut-off was 34 DIM (Se, 80.9%; Sp, 66.7%; AUC, 0.74; P < 0.01). No differences (P>0.05) were detected between groups on the BCS and milk production. The average of milk production in both groups was 46.65 ± 6.15 Kg/day. Cows that reached the nadir BCS Early postpartum presented lower (P < 0.01) calving interval, and greater (P < 0.01) pregnancy at first AI and P150. In summary, cows that lost BCS early had better reproductive performance and had similar milk yield compared with cows that lost BCS late in the postpartum period.
Prognostic significance of Inflammatory and Nutritional Markers in Perioperative Period for Patients with Advanced Gastric Cancer
Authors: Zhang Ruolan , Hu Can , Zhang Jiaqing , Zhang Yanqiang , Li Yuan , Yu Pengcheng , Wang Yi , Bao Zhehan , Cao Mengxuan , Ruan Rongwei , Cheng Xiangdong , Xu Zhiyuan 
Published: September 2022

Abstract
Background:
It has been reported that inflammatory and nutritional markers are related to prognosis in numerous malignancies. The present study analyzed the significance of these markers’ alterations during neoadjuvant chemotherapy in the long-term outcomes in patients with advanced gastric cancer.
Methods:
A retrospective review was performed of 437 advanced gastric cancer patients who underwent a neoadjuvant chemotherapy (NACT) regimen followed by surgical treatment. Blood samples for inflammatory and nutritional markers were collected from the patients before the first neoadjuvant chemotherapy and after the last neoadjuvant chemotherapy. Statistical analysis, including MannWhitney U or chisquare tests, the KaplanMeier method and Cox multivariate analysis, were performed to analyze the predictive value of these markers for overall survival outcomes (OS).
Results:
Most biomarkers, including lymphocyte, leucocyte, neutrophil, monocyte, platelet, LMR, PLR, SII, CRP, CAR, hemoglobulin and albumin levels, changed during NACT (P < 0.05). After separately grouping the patients according to the normal range of hematologic indexes and the change rate (α) of systemic inflammatory and nutritional markers by the cutoff value derived from X-tile (P < 0.05), we found that differentiation, TRG, pre-NACT BMI, pre-NACT platelet counts, post-NACT lymphocyte counts, the change in lymphocyte counts, change in platelet counts and LMR(α), PLR(α), SII(α), and CAR(α) were associated with OS. Multivariate analysis revealed that PLR (α) > -19% was correlated with a 3.193-fold (95% CI: 2.194–4.649) higher risk of death (P < 0.001) than others.
Conclusion:
NACT could significantly change several inflammatory and nutritional markers in the perioperative period; the platelet counts before NACT, and the change in lymphocytes during NACT truly correlated with long-term outcomes among patients with advanced gastric cancer. The systemic inflammatory marker PLR may be a reliable marker for the prediction of prognosis.
Design and numerical analysis of large negative dispersion and ultra-high nonlinearity CS 2 -core LCPCF
Authors: Feng Yongkang , Jiang Shubo , Feng Chun 
Published: September 2022

Abstract
Through filling CS2 into the core, a liquid-core photonic crystal fiber(LCPCF) with a fully circular air hole structure was designed The finite element method(FEM) and numerical analysis are combined to simulate the structure and optimize the parameters of the fiber. When λ = 1550 nm, the geometric optimal parameters are Ʌ = 0.75 μm, d1/Ʌ = 0.86, d2/Ʌ = 0.96, and d3/Ʌ = 0.20. Meanwhile, the LCPCF can achieve a large negative dispersion of -2697.06 ps/nm/km and a high nonlinearity of 50677.77 W-1km-1. The numerical aperture and light acceptance are 0.674 and 65.37%, respectively. By comparison, we believe that this LCPCF has obvious advantages in optical communication compensation and supercontinuum generation.
The Epidemiological Characteristics of Ventilator-associated Pneumonia in Neurosurgery: A Ten-year Surveillance Study in A Large Chinese Tertiary Hospital
Authors: Yu Zheng-Hao , Li Xin-Lou , Lv Cheng-Long , Tian Yao , Suo Ji-Jiang , Yan Zhong-Qiang , Bai Yan-Ling , Liu Bo-Wei , Fang Li-Qun , Du Ming-mei , Yao Hong-Wu , Liu Yun-Xi 
Published: September 2022

Abstract
Background: Ventilator-associated pneumonia (VAP) is a significant and common health concern, and epidemiological landscape of VAP is poorly understood in neurosurgery. The current study aimed to explore the epidemiology of VAP in neurosurgery with the goal of devising better-targeted surveillance, treatment and control efforts.
Methods: A ten-year retrospective study was performed in a large Chinese tertiary hospital, and we collected surveillance data on neurosurgical patients with VAP and used descriptive analysis to map the demographic and clinical characteristics of VAP as well as the distribution and antimicrobial resistance profile of leading pathogens. Risk factors associated with the presence of VAP were explored using boosted regression tree (BRT) models.
Results: During 2011-2020, a total of 310 VAP patients were identified. The ten-year incidence of VAP was 16.21 per 1000 ventilation days with all-cause mortality rate of 6.1%. The proportions of gram-negative bacteria, fungi and gram-positive bacteria in 357 isolates from 310 VAP patients were 86.0%, 7.6% and 6.4%, and most of them were multidrug-resistant organisms. Acinetobacter baumannii, Klebsiella pneumoniae, and Pseudomonas aeruginosa were the most common pathogens causing VAP, and high detection rates of CRAB, CRPA and CRKP with an upward trend were observed. The BRT modes revealed that there were various associations of VAP presence with the days of ventilator use (relative contribution: 47.84 ± 7.25), GCS score (relative contribution: 24.72 ± 5.67), and tracheotomy (relative contribution: 21.50 ± 2.69), respectively.
Conclusions: Our findings provide a better understanding of epidemiological characteristics and risk factors for VAP in neurosurgery.
Dynamic Allocation of 5G Network Resources using Game Theory
Authors: Bamdad Mostafa , jamali Shahram , Fotohi Reza 
Published: September 2022

Abstract
Standardization of "Network Slice", which is an important part of resource allocation among innovations emerging in 5G networks, is considered a vital and important issue in the research community. The network slice to support one or more specific services is modified and changed according to the needs of that service. These slices provide an efficient basis for dividing the infrastructure between different entities, each of which has a slice. In this research, a proposed method for allocation of cache storage resources with a network Slicing scenario in the core network of the fifth generation of communications using game theory and specifically the bankruptcy game in order to improve the quality of the end user's experience has been presented. Game theory is a field of applied mathematics that is developed in the context of economics and studies strategic behavior between rational agents. In general, the Shapley method has improved by 5% in the user satisfaction index compared to the proportional allocation method. In the fairness index, Shapley's allocation method and proportional allocation method have both improved by 27% compared to the minimum-maximum method. In the fairness index of the quality of experience, Shapley's method and proportional allocation method are equal. Shepley's method and proportional allocation compared to the minimum-maximum method have improved 4% in the fairness index of experience quality. The results clearly show the fairness of the Shapley allocation method and proportional allocation, and in some aspects, these two have been different from each other, which has been discussed in detail. End-to-end multi-resource allocation using the bankruptcy game can be mentioned for future work in the existing field.
Second language learning at school enhances Theory of Mind skills
Authors: Agostini Valeria , Apperly Ian , Krott Andrea 
Published: September 2022

Abstract
Early learning of a second language at home has been found to be beneficial for children’s cognitive development, including their ability to ascribe mental states to others, also called Theory of Mind. We investigated whether later second language learning in an educational setting can accelerate children’s Theory of Mind development and whether the amount of exposure to second language education makes a difference. We tested three groups of monolingual four-five year old children with varying language exposure at the beginning of their first year at primary school and 24 weeks later. Children attending bilingual schools and children with weekly short second language lessons exhibited very similar accelerated Theory of Mind development compared to children without any second language provision. Theory of Mind advances were not related to other cognitive advances. Thus, limited foreign language teaching can boost young children’s social cognitive development, providing an enhanced basis for their social competence development.
Introgression of Agropyron cristatum genes to counteract the negative relationship between grain number and grain weight of wheat
Authors: Lin Yida , Zhou Shenghui , Liang Xuezhong , Han Bing , Yang Junli , Guo Baojin , Zhang Jingpeng , Han Haiming , Liu Weihua , Yang Xinming , Li Xiuquan , Li Lihui 
Published: September 2022

Abstract
Agropyron cristatum (2n = 4X = 28, PPPP), which harbour many high-yield and disease-resistance genes, is a promising donor for wheat improvement. Narrow genetic diversity and the trade-off between grain weight and grain number have become bottlenecks for increasing grain yield. In this study, WAT650l, a new translocation line was generated via radiation (60Co-γ rays)-based mutation induction of chromosome 6P addition line 4844-12. Cytological analysis and molecular marker analysis revealed that WAT650l was a 6PL (bin ~ 12–17)·5BS-5BL translocation line. Assessment of agronomic traits and analysis of the BC4F2 and BC5F2 populations suggested that the 6PL terminal chromosome segment in WAT650l resulted in increased flag leaf length, plant height (PH), spikelet number per spike (SNS), kernel number per spikelet (KNS), grain number per spike (GNS) (average increased by 14.07 grains) and thousand-grain weight (TGW) (average increased by 4.31 g) during the growing seasons of 2020–2021 and 2021–2022. Additionally, the increased GNS locus and high-TGW locus of WAT650l were mapped to 6PL (16–17) and 6PL (12–13), respectively, by genetic population analysis of three translocation lines. In summary, by using high-yield genes of A. cristatum and overcoming the negative relationship between GNS and TGW associated with wheat breeding, we provide a valuable germplasm resource for broadening the genetic base of wheat.
Dietary bamboo leaf flavonoids improve quality and microstructure of broiler meat by changing untargeted metabolome
Authors: Cao Guangtian , Wang Huixian , Yu Yang , Tao Fei , Yang Huijuan , Yang Shenglan , Qian Ye , Li Hui , Yang Caimei 
Published: September 2022

Abstract
Background
Dietary bamboo leaf flavonoids (BLFs) are rarely used in poultry production, and it is unknown whether they influence meat texture profile, perceived color, or microstructure.
Results
A total of 720 one-day-old Arbor Acres broilers were supplemented with a basal diet with 20 mg bacitracin/kg, 50 mg BLFs/kg, or 250 mg BLFs/kg or without additions. Data showed that the dietary BLFs significantly (p < 0.05) changed growth performance and the texture profile. In particular, BLFs increased birds’ average daily gain and average daily feed intake, decreased the feed:gain ratio and mortality rate, improved elasticity of breast meat, enhanced the gumminess of breast and leg meat, and decreased the hardness of breast meat. Moreover, a significant (p < 0.05) increase in redness (a*) and chroma (c*) of breast meat and c* and water-holding capacity of leg meat was found in BLF-supplemented broilers compared with control broilers. In addition, BLF supplementation significantly decreased (p < 0.05) the β-sheet ratio and serum malondialdehyde and increased the β-turn ratio of protein secondary structure, superoxide dismutase, and glutathione peroxidase of breast meat and total antioxidant capacity and catalase of serum. Based on the analysis of untargeted metabolome, BLF treatment considerably altered 14 metabolites of the breast meat, including flavonoids, amino acids, and organic acids, as well as phenolic and aromatic compounds.
Conclusions
Dietary BLF supplementation could play a beneficial role in improving meat quality and sensory color in the poultry industry by changing protein secondary structures and modulating metabolites.
Laparoscopy-assisted trans gastric wedge resection: A safe treatment for gastric pyloric liposarcoma: a case report and literature review
Authors: Paredes Oscar , Eom Sang Soo , Park Sin Hye , Kim Young-Woo 
Published: September 2022

Abstract

Background
Gastric liposarcoma (GL) is extremely rare and radical surgery has been the conventional treatment, even in small tumors. Laparoscopic wedge resection has been reported worldwide forsubepithelial tumors of the stomach.
Case Presentation
The patient was an asymptomatic 63-year-old man presenting with a subepithelial gastric tumor. The esophagogastroduodenoscopy showed a 3 cm ulcerated soft tumor located in the posterior wall of the antrum just above the pylorus. Two preoperative biopsies were performed with a negative result for malignant neoplasm. Dynamic computerized tomography revealed 35x35mm well-defined pyloric mass with fat density. Despite the difficult location of the tumor, parenchyma-sparing surgery was performed. Surgery was initiated by a laparoscopic approach with four trocars. After the dissection of the greater omentum, the greater curvature and the posterior wall of the stomach were exposed. A gastrostomy was performed in the anterior wall of the antrum. Due to the difficulty in identifying the tumor location, a mini-laparotomy was conducted. After assessing the pylorus and section parameters, the tumor was extracted by gastrostomy and resected with a linear stapler. The patient was discharged after five days with no complications. The histological diagnosis was a well-differentiated liposarcoma. Resection margins were clear. The tumor cells tested negative for MDM2. No adjuvant therapy was indicated. The patient is alive without recurrence.
Conclusions
Despite its rarity, gastric liposarcoma should be respected for differential diagnosis. Minimally invasive wedge resection might be a suitable treatment even if the location is close to the pylorus.
Characterization and In-vitro Investigation of Tridax Procumbens Blended PVA Thin Membrane for Wound-Dressing Applications
Authors: Ayyanar C. Balaji , Gayathri B. , Rangappa Sanjay Mavinkere , Siengchin Suchart 
Published: September 2022

Abstract
The authors have requested that this preprint be removed from Research Square.
IGH rod-like tracer: An AlphaFold2 structural similarity extraction-based predictive biomarker for minimal residual disease monitoring in children with precursor B-cell acute lymphoblastic leukemia
Authors: Zhuo Zhongling , Wang Qingchen , Li Chang , Zhang Lili , Zhang Lanxin , You Ran , Gong Yan , Hua Ying , Miao Linzi , Bai Jiefei , Zhang Chunli , Feng Ru , Chen Meng , Su Fei , Qu Chenxue , Xiao Fei 
Published: September 2022

Abstract
Sequence variation resulting from the evolution of IGH clones and immunophenotypic drift makes it difficult to track abnormal B cells in children with precursor B-cell acute lymphoblastic leukemia (pre-B-ALL) by flow cytometry, quantitative polymerase chain reaction (qPCR), or next-generation sequencing (NGS). This study aimed to identify immunoglobulin heavy-chain genes (IGH) rod-like tracer as an effective biomarker for dynamic minimal residual disease (MRD) monitoring in children with pre-B-ALL. The V-(D)-J regions of immunoglobulin and T cell receptor of 47 pre-B-ALL samples were sequenced using the Illumina NovaSeq platform. The complementarity determining region 3 (CDR3) sequences (proportion > 5%) were identified, the IGH rod-like tracer consensus sequence was extracted based on its rod-like alpha-helices structural similarity predicted by AlphaFold2. Additional data from published 203 pre-B-ALL samples were applied for validation. NGS-IGH (+) patients with pre-B-ALL had a poor prognosis. Consistent CDR3 coded protein structures in NGS-IGH (+) samples could be extracted as a potential follow-up marker for children with pre-B-ALL during treatment. IGH rod-like tracer from quantitative immune repertoire sequencing may serve as a new class of biomarker with significant predictive values for the dynamic monitoring of MRD in children with pre-B-ALL.
Time-magnitude correlations and time variation of the Gutenberg-Richter
parameter in foreshock sequences
Authors: Apostol Bogdan Felix , Cune Liviu Cristian 
Published: September 2022

Abstract
The time dependence of the parameter of the Gutenberg-Richter (GR)
magnitude distribution is computed for foreshock sequences of earthquakes,
correlated with the main shock, by using the geometric-growth model
of earthquake focus, the magnitude distribution of correlated earthquakes
and the time-magnitude correlations, derived recently. It is shown
that this parameter decreases in time in the foreshock sequence, from
the background values down to the main shock. If correlations are
present, this time dependence and the time-magnitude correlations
provide a tool of monitoring the foreshock seismic activity. We discuss
the relevance of such an analysis for the occurrence moment and the
magnitude of a main shock. The discussion is applied to a few Vrancea
main shocks and the precursory seismic activity of the l'Aquila earthquake.
The limitations of such an analysis are discussed.
Prenatal and childhood chlordecone exposure, intellectual abilities and problem behaviors in 7-year-old children: the TIMOUN mother-child cohort in Guadeloupe
Authors: Oulhote Youssef , Rouget Florence , Michineau Léah , Monfort Christine , Desrochers-Couture Mireille , Thomé Jean-Pierre , Kadhel Philippe , Multigner Luc , Cordier Sylvaine , Muckle Gina 
Published: September 2022

Abstract
Background:Chlordecone is a highly persistent organochlorine insecticide that was intensively used in banana fields in the French West Indies, therefore resulting in a widespread contamination of soils, water sources and foodstuff. Neurotoxicity of acute exposures in adults is well recognized, and empirical data suggests that prenatal exposure affects visual recognition memory and fine motor development during infancy, and visual contrast sensitivity at school age, with greater susceptibility in boys.
Objective:To assess the associations between pre- and postnatal exposures to chlordecone and intellectual and behavioral functions in school-aged children from Guadeloupe.
Methods:We examined 576 children from the TIMOUN mother-child cohort in Guadeloupe at 7 years of age. Concentrations of chlordecone and other environmental contaminants were measured in cord- and children’s blood at age 7 years. Intellectual abilities of children were assessed with the Wechsler Intelligence Scale for Children-IV (WISC-IV), and externalizing and internalizing problem behaviors documented with the Strengths and Difficulties Questionnaire (SDQ) completed by the child’s mother. We estimated covariate-adjusted associations between cord- and 7-years chlordecone concentrations and child outcomes using structural equations modeling, and tested effect modification by sex.
Results: Blood chlordecone concentrations were 0.13 µg/L in cord blood and 0.06 µg/L in children’s blood at age 7 years (geometric means [GM]). A twofold increase in cord blood concentrations was associated with 0.05 standard deviation (SD) (95% Confidence Interval [CI]: 0.0, 0.10) higher internalizing problem scores, whereas 7-years chlordecone concentrations were associated with lower Full-Scale IQ scores (FSIQ) and greater externalized behavioral problem scores. A twofold increase in 7-year chlordecone concentrations was associated with a decrease of 0.67 point (95% CI: -1.13, -0.22) on FSIQ and an increase of 0.04 SD (95% CI: 0.0, 0.07) on externalizing problems. These associations with intellectual abilities were driven by decreases in perceptive reasoning, working memory and verbal comprehension. In sex-stratified analyses, associations between 7-year exposure and perceptive reasoning, working memory, and the FSIQ were stronger in boys, whereas cord blood and child blood associations with internalizing problems were stronger in girls.
Conclusions: These results suggests that intellectual abilities and externalizing behavior problems at school age are impaired by childhood, but not in utero, exposure to chlordecone, and that prenatal exposure is related to greater internalizing behavioral problems. The persistence of these effects at later age remains to be elucidated.
In silico process modeling of effect of MoTe2 as hole transport layer in CuSbS2 absorber based solar cells using SCAPS-1D software
Authors: Ghosh Chandrama , Ghosh Probir Kumar 
Published: September 2022

Abstract
Copper antimony sulphide (CuSbS2) is a suitable material for construction of solar cells as an absorber, since it increases absorption of solar radiation in cells, and hence energy generation. Another material, MoTe2, which acts as a hole transport layer (HTL) is also preferred for solar cells design. MoTe2 HTL provides an addition back surface field that increases the collection of holes at back contact, thus facilitating generation of photonic energy. The presented research involves an in-silico examination of their tandem effect in solar energy generation, using the simulation software SCAPS-1D. Results reveal that in the MoTe2 HTL solar cells having 2500 nm thickness of CuSbS2 absorber layer, the maximum power conversion efficiency achieved was 30.4%, at a bandgap of 1.4 eV. The effects of energy bandgap and thickness of CuSbS2 absorber layer on performance parameters of solar cells containing short-circuit current (Jsc), open-circuit voltage (Voc), and fill factor (FF) were also studied. Further, effect of operating temperature was also examined to analyse feasibility on outdoor installation of the designed solar cell.