bluuebunny/crossref_metadata_2025_split huggingface dataset:
Wireless light energy harvesting and communication in a waterproof GaN optoelectronic system
Authors: Gao Xumin , Liu Pengzhan , Yin Qingxi , Wang Hao , Fu Jianwei , Hu Fangren , Jiang Yuan , Zhu Hongbo , Wang Yongjin 
Published: July 2022

AbstractWireless technologies can be used to track and observe freely moving animals. InGaN/GaN light-emitting diodes (LEDs) allow for underwater optical wireless communication due to the small water attenuation in the blue-green spectrum region. GaN-based quantum well diodes can also harvest and detect light. Here, we report a monolithic GaN optoelectronic system (MGOS) that integrates an energy harvester, LED and SiO2/TiO2 distributed Bragg reflector (DBR) into a single chip. The DBR serves as waterproof layer as well as optical filter. The waterproof MGOS can operate in boiling water and ice without external interconnect circuits. The units transform coded information from an external light source into electrical energy and directly activate the LEDs for illumination and relaying light information. We demonstrate that our MGOS chips, when attached to Carassius auratus fish freely swimming in a water tank, simultaneously conduct wireless energy harvesting and light communication. Our devices could be useful for tracking, observation and interacting with aquatic animals.
Room-temperature formation of alloy ZnxCd13−xSe13 magic-size clusters via cation exchange in diamine solution
Authors: Zhu Weijun , Lin Zhuohan , Zhang Xue , Wang Wei , Li Yan 
Published: July 2022

Alloy ZnxCd13−xSe13 MSCs (x = 1–12) with a unique sharp absorption peak at 352 nm are prepared by cation exchange between Cd2+ ions and pre-synthesized (ZnSe)13 MSCs in diamine solution at room temperature.
Comparison of Lingual Pressure Generation Capacity in Parkinson Disease, Amyotrophic Lateral Sclerosis, and Healthy Aging
Authors: Gandhi Pooja , Plowman Emily K. , Steele Catriona M. 
Published: July 2022

Purpose:
The tongue plays a key role in bolus propulsion during swallowing, with reduced lingual pressure generation representing a risk factor for impaired swallowing safety and efficiency. We compared lingual pressure generation capacity in people with Parkinson disease (PwPD), people with amyotrophic lateral sclerosis (PwALS), and healthy older adults. We hypothesized that both patient cohorts would demonstrate reduced maximum anterior isometric pressure (MAIP) and regular effort saliva swallow (RESS) pressures compared with healthy controls, with the greatest reductions expected in the ALS cohort.

Method:
We enrolled 20 PwPD, 18 PwALS, and 20 healthy adults over 60 years of age. The Iowa Oral Performance Instrument was used to measure MAIP, RESS, and lingual functional reserve (LFR, i.e., MAIP – RESS). Descriptive statistics were calculated; between-groups differences were explored using univariate analyses of variance and post hoc Sidak tests with alpha set at .05.

Results:
Mean MAIPs for the PD, ALS, and heathy cohorts were 54.7, 33.5, and 47.4 kPa, respectively. Significantly lower MAIP was found in PwALS compared with PwPD and healthy controls. RESS values did not differ significantly across groups. LFR was significantly higher in PwPD versus PwALS and healthy controls.

Conclusions:
Lingual pressure generation capacity and functional reserve were reduced in PwALS, but not in PwPD, beyond changes seen with healthy aging. Both patient cohorts displayed preserved lingual pressure during saliva swallows. Future studies exploring longitudinal changes in tongue pressure generation on isometric and saliva swallowing tasks will be needed to confirm whether tongue pressure measures serve as noninvasive clinical biomarkers of swallowing impairment.
Formation and heating of chromospheric fibrils in a radiation-MHD simulation
Authors: Druett M. K. , Leenaarts J. , Carlsson M. , Szydlarski M. 
Published: July 2022

Aims. We examine the movements of mass elements within dense fibrils using passive tracer particles (corks) in order to understand the creation and destruction processes of fibrils.
Methods. Simulated fibrils were selected at times when they were visible in a Hα image proxy. The corks were selected within fibril Hα formation regions. From this set, we selected a cork and constructed the field line passing through it. Other fibrilar corks close to this field line were also selected and pathlines were constructed, revealing the locations of the mass elements forwards and backwards in time. Finally, we analysed the forces acting on these mass elements.
Results. The main process of fibrilar loading in the simulation is different to the mass loading scenario in which waves steepen into shocks and push material upwards along the field lines from locations near their footpoints. The twisted, low-lying field lines were destabilised and then they untwisted, lifting the material trapped above their apexes via the Lorentz force. Subsequently, the majority of the mass drained down the field lines towards one or both footpoints under the influence of gravity. Material with large horizontal velocities could also be elevated in rising field lines, creating somewhat parabolic motions, but the material was not generally moving upward along a stationary magnetic field line during loading.
Conclusions. The processes observed in the simulation are additional scenarios that are plausible. The criteria for observing such events are described in this work. We note that it is desirable for our simulations to also be able to form more densely packed fibrils from material fed from the base of field footpoints. The experimental parameters required to achieve this are also discussed in this paper.
Desorption of organic molecules from interstellar ices, combining experiments and computer simulations: Acetaldehyde as a case study
Authors: Molpeceres G. , Kästner J. , Herrero V. J. , Peláez R. J. , Maté B. 
Published: July 2022

Context. Explaining the presence of complex organic molecules (COMs) in interstellar environments requires a thorough understanding of the physics and chemistry occurring in the interplay between the gas phase and interstellar surfaces. Experiments and computer simulations are pivotal in building a comprehensive catalogue of processes of relevance for the build up of organic molecules in those environments.
Aims. We combine experiments with tailored computer simulations to study the desorption dynamics of acetaldehyde CH3CHO – an important organic precursor in cold interstellar environments - on amorphous solid water for the first time. Our goals with this paper are twofold. Firstly, we want to contextualise the role of this molecule in the evolution of organic molecules in space. Secondly, we want to suggest a joint scheme to produce quantitative information on desorption magnitudes based on the combination of computations and experiments. This scheme can be adopted to refine measurements of other molecules.
Methods. We determined desorption energies and pre-exponential factors of desorption theoretically using molecular dynamics simulations that combine semi-empirical and density functional calculations. We also performed temperature-programmed desorption experiments with acetaldehyde on top of non-porous amorphous solid water. The combination of theoretical and experimental results allows us to derive reliable quantities, which are required for understanding the desorption dynamics of interstellar COMs (iCOMs) atop interstellar ices.
Results. The average theoretical and experimental desorption energies found for CH3CHO desorbing from non-porous amorphous solid water (np-ASW) surfaces are 3624 K and 3774 K, respectively. The pre-exponential factor determined theoretically is vtheo = 2.4 × 1012 s−1 while from the experiments it was possible to constrain this magnitude to 1012±1 s−1.
Conclusions. The comparison of the desorption energies of CH3CHO with other COMs, such as CH3NH2 or CH3NO, shows that CH3CHO is more volatile. Therefore, we suggest that, in consideration of the average binding energy, CH3CHO should undergo preferential desorption during the ice-sublimation phase in hot cores enriching the gas-phase in this particular component. In addition, the overall low binding energy suggests a possible early return to the gas phase of pre-stellar cores due to non-thermal effects (i.e. reactive desorption or cosmic-ray-induced desorption). This could explain the prevalence of CH3CHO in the gas phase of pre-stellar cores. Dedicated laboratory and theoretical efforts are required to confirm this last point.
Stimmungsschwankungen
Authors: Houben Martina , Welsch Katja , Feldhaus Simon , Spajic Emilia 
Published: July 2022

SummaryVier Experten stellen Behandlungsansätze bei Stimmungschwankungen mithilfe von Phytotherapie, Homöopathie, Akupunktur und Orthomolekularmedizin vor.
Altbewährt mit moderner Technologie
Authors: Steffen Julia 
Published: July 2022

SummaryUrin enthält Tausende Metabolite aus dem Stoffwechsel und kann so als Spiegel des Gesundheitszustands und chemischer Fingerabdruck dienen. Im Vergleich zu anderen diagnostischen Methoden wie der Blutuntersuchung bietet die Urindiagnostik einige Vorteile, zum Beispiel sind viele Parameter in einem Urinröhrchen messbar. Die Urindiagnostik kann beispielsweise über die Tryptophan-, Neurotransmitter- und TMAO-Stoffwechsellage, bakterielle urämische Metabolite, organische Säuren, ROS, RNS und Umweltbelastungen Aufschluss geben.
Mechanism of Olibanum and Myrrha for the Acute Soft Tissue Injury Based on Network Pharmacology
Authors: Tan Miao , Cheng Yan 
Published: July 2022

Abstract
Objective The objective of this study was to screen the therapeutic target of olibanum and myrrha on acute soft tissue injury (ASTI) by network pharmacology and to clarify their mechanisms.
Methods The main chemical constituents and the targets of olibanum and myrrha were obtained by using traditional Chinese medicine systems pharmacology database and analysis platform database. The disease targets of ASTI were searched by GeneCards. The intersection targets of herbs and diseases were selected for protein interaction analysis, protein–protein interaction network was constructed, and potential protein functional modules in the network were explored. A compound–target–disease network was constructed using Cytoscape3.8.2 software. The targets were analyzed by gene ontology analysis and Kyoto Encyclopedia of Genes and Genomes enrichment analysis based on the Metascape database.
Results The core active components of olibanum and myrrha were quercetin, β-sitosterol, and stigmasterol. The core targets were PGR, NCOA2, PTGS2, PRKCA, and NR3C2. Pathways in cancer, AGE-RAGE signaling pathway in diabetic complications might play a potential role in olibanum and myrrha in the treatment of ASTI.
Conclusion Olibanum and myrrha have the characteristics of multiple components, multiple targets, and overall regulation in the treatment of ASTI.
Potential Targets and Molecular Mechanism of Quercetin Against Knee Osteoarthritis
Authors: Li Lingling , Huang Hailiang 
Published: July 2022

AbstractObjective The objective of this study was to clarify the potential mechanism of quercetin against knee osteoarthritis (KOA) based on network pharmacology and molecular docking.Methods The targets of quercetin were predicted by PubChem and Swiss Target Prediction databases, and the targets of KOA were obtained by DisGeNET, OMIM, and GeneCards databases. Then, the targets of quercetin and KOA were intersected to find the potential targets of quercetin against KOA. The protein–protein interaction network was constructed through the STRING database, and the core targets were screened. Gene ontology (GO) functions enrichment analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis were performed using DAVID database. The drug–target–pathway–disease network was constructed by Cytoscape software, and the molecular docking verification was performed by Vina.Results There were 49 potential targets for quercetin against KOA, including 10 core targets. GO functions enrichment analysis showed that the biological process of quercetin against KOA mainly involved the negative regulation of apoptotic process, collagen catabolic process, and extracellular matrix disassembly. KEGG pathway enrichment analysis showed that quercetin against KOA was closely related to PI3K-Akt signaling pathway, Rap 1 signaling pathway, FoxO signaling pathway, Ras signaling pathway, TNF signaling pathway, and ErbB signaling pathway. The results of molecular docking showed that the binding energies between ligand and receptors were less than −5 kcal • mol−1.Conclusions The molecular mechanism of quercetin against KOA involves many targets and pathways, which can regulate the proliferation and apoptosis of chondrocytes, degradation of extracellular matrix, and inflammatory reaction. Quercetin can stably bind to the active pockets of core target proteins, thereby exerting the effect against KOA.
Arthroscopic Meniscal Healing following Medial Meniscus Posterior Root Repair: A Comparison between Two Suture Materials
Authors: Okazaki Yuki , Furumatsu Takayuki , Hiranaka Takaaki , Zhang Ximing , Kintaka Keisuke , Higashihara Naohiro , Tamura Masanori , Kodama Yuya , Kamatsuki Yusuke , Ozaki Toshifumi 
Published: July 2022

AbstractRecently, transtibial pullout repair of the medial meniscus (MM) posterior root tear (PRT) has become widely accepted and provides satisfactory clinical outcomes. Widening after cyclic loading or ultimate failure load using different suture materials and configurations has been studied. However, no study has compared the clinical outcomes using different suture materials. This study aimed to evaluate the clinical outcomes after performing MMPRT pullout repair using different suture materials. We hypothesized that better clinical outcomes would be achieved using ultra-high molecular weight polyethylene (UHMWPE) tape compared with a normal polyester suture. Thirty-seven patients who underwent MM posterior root repair between November 2019 and May 2020 were retrospectively investigated. Pullout repair was performed using a hollow no. 0 polyester suture (n = 14) and UHMWPE tape (n = 23). Clinical outcomes were assessed preoperatively and at 1 year postoperatively, using the Lysholm knee score, Knee Injury and Osteoarthritis Outcome Score, and visual analogue scale (VAS) pain score. The meniscal healing status was assessed using an arthroscopic scoring system (range: 0–10). All clinical scores were improved significantly in both groups. However, significantly higher meniscal healing scores and decreased VAS pain scores were observed in the UHMWPE group (7.3 ± 0.9 and 7.7 ± 11.3, respectively) than in the polyester group (5.6 ± 2.1 and 18.4 ± 18.6, respectively; p < 0.01). Suture cut-out and loss of the root continuity were observed in some cases (three cases [21.4%] in the polyester suture group and one case [4.3%] in the UHMWPE tape group). Both suture materials led to satisfactory clinical outcomes at 1 year postoperatively, whereas the UHMWPE tape was useful for obtaining good meniscal healing and decreasing the VAS pain score.
Reduction of the Number of Live Animals Used for Microsurgical Skill Acquisition: An Experimental Randomized Noninferiority Trial
Authors: Eșanu Victor , Stoia Alexandra I. , Dindelegan George C. , Colosi Horaţiu A. , Dindelegan Maximilian G. , Volovici Victor 
Published: July 2022

Abstract
Background Live animals have been used for decades as one of the many training models for developing surgical skills. Microsurgery in particular relies on training for skill acquisition and maintenance, using live animal models, especially rats (murine models). Efforts are underway to reduce the number of rats sacrificed to achieve this objective.
Methods A group of students with minimal microsurgical experience, after having gone through a basic microsurgical course, were randomly split into three equal groups, all three groups following a 24-week standard training program based on low- and medium-fidelity training models with standardized murine training days. In addition to the standard training regimen, each participant performed supplementary training on live rats every 4, 6, or 8 weeks. According to the training program, the procedures have been performed on chicken legs, flower petals, and rats, each procedure being blindly assessed and evaluated using validated models and scales. The primary evaluated outcome was the Stanford Microsurgery and Resident Training (SMaRT) scale result of the final rat anastomosis performed by each group, for which the tested hypothesis was one of noninferiority. The secondary outcomes were represented by the final rat anastomosis time, final chicken leg anastomosis result and time, and the final petal score.
Results After the 24th week, no differences were observed between the three groups regarding their microsurgical skills, as measured by the aforementioned surgical outcomes. All participants improved significantly during the study (mean [standard deviation] 19 ± 4 points on the SMaRT scale), with no significant differences between the groups, p < 0.001 for noninferiority.
Conclusion A training regimen based on low- and moderate-fidelity models, with the addition of training on a live rat every 8 weeks was noninferior to a training regimen that used a live rat every 6 weeks and also noninferior to a training regimen that used a live rat every 4 weeks.
Management Considerations for Unicompartmental Osteoarthritis in Athletic Populations: A Review of the Literature
Authors: Wake Jeffrey L. , Chung Brandon , Bottoni Craig R. , Zhou Liang 
Published: July 2022

AbstractUnicompartmental osteoarthritis in the young athlete poses a challenge for both patients and providers. Coronal plane malalignment is frequently a concomitant finding that adds to the complexity of management. Military surgeons are presented unique challenges, in that they must consider optimal joint-preservation methods while returning patients to a high-demand occupational function. Management options range from lifestyle changes to surgical interventions. We present a concise review of the available literature on this subject, with a specific focus on indications and outcomes within the military and young athletic population.
Increment of Maternal Mortality Among Admissions for Childbirth in Low-risk Pregnant Women in Brazil: Effect of COVID-19 Pandemic?
Authors: Michels Bruna Depieri , Marin Daniela Ferreira D'Agostini , Iser Betine Pinto Moehlecke 
Published: July 2022

Abstract
Objective To assess the possible impact of the COVID-19 pandemic on maternal mortality among admissions for childbirth in 2020 in relation of the last 10 years.
Methods An ecological study with pregnant women who underwent hospital births at the Brazilian unified public health service (SUS, in the Portuguese acronym) in Brazil from 2010 to 2020. The mortality among admissions for childbirth was obtained based on the number of admissions for childbirth with reported death as outcome divided by the total number of admissions. The underlying gestational risk and route of delivery were considered based on the national surveillance system. The average mortality for the period between 2010 and 2019 (baseline) was compared with the rate of deaths in 2020 (1st pandemic year); the rate ratio was interpreted as the risk of death in 2020 in relation to the average of the previous period (RR), with 95% confidence intervals (CIs).
Results In 2020, the 1st year of the COVID-19 pandemic, 1,821,775 pregnant women were hospitalized for childbirth and 651 deaths were reported, which represents 8.7% of the total hospitalizations and 11.3% of maternal deaths between 2010 and 2020. There was an increase in maternal mortality after births in 2020 compared with the average for the period between 2010 and 2019, specially in low-risk pregnancies, both in vaginal (RR = 1.60; 95%CI:1.39–1.85) and cesarean births (RR = 1.18; 95%CI:1.04–1.34).
Conclusion Maternal mortality among admissions for childbirth according to SUS data increased in 2020 compared with the average between 2010 and 2019, with an increment of 40% in low-risk pregnancies. The increase was of 18% after cesarean section and of 60% after vaginal delivery.
The ZCCHC14/TENT4 complex is required for hepatitis A virus RNA synthesis
Authors: Li You , Misumi Ichiro , Shiota Tomoyuki , Sun Lu , Lenarcic Erik M. , Kim Hyejeong , Shirasaki Takayoshi , Hertel-Wulff Adriana , Tibbs Taylor , Mitchell Joseph E. , McKnight Kevin L. , Cameron Craig E. , Moorman Nathaniel J. , McGivern David R. , Cullen John M. , Whitmire Jason K. , Lemon Stanley M. 
Published: July 2022

Despite excellent vaccines, resurgent outbreaks of hepatitis A have caused thousands of hospitalizations and hundreds of deaths within the United States in recent years. There is no effective antiviral therapy for hepatitis A, and many aspects of the hepatitis A virus (HAV) replication cycle remain to be elucidated. Replication requires the zinc finger protein ZCCHC14 and noncanonical TENT4 poly(A) polymerases with which it associates, but the underlying mechanism is unknown. Here, we show that ZCCHC14 and TENT4A/B are required for viral RNA synthesis following translation of the viral genome in infected cells. Cross-linking immunoprecipitation sequencing (CLIP-seq) experiments revealed that ZCCHC14 binds a small stem-loop in the HAV 5′ untranslated RNA possessing a Smaug recognition-like pentaloop to which it recruits TENT4. TENT4 polymerases lengthen and stabilize the 3′ poly(A) tails of some cellular and viral mRNAs, but the chemical inhibition of TENT4A/B with the dihydroquinolizinone RG7834 had no impact on the length of the HAV 3′ poly(A) tail, stability of HAV RNA, or cap-independent translation of the viral genome. By contrast, RG7834 inhibited the incorporation of 5-ethynyl uridine into nascent HAV RNA, indicating that TENT4A/B function in viral RNA synthesis. Consistent with potent in vitro antiviral activity against HAV (IC
50
6.11 nM), orally administered RG7834 completely blocked HAV infection in

Ifnar1
−/−

mice, and sharply reduced serum alanine aminotransferase activities, hepatocyte apoptosis, and intrahepatic inflammatory cell infiltrates in mice with acute hepatitis A. These results reveal requirements for ZCCHC14-TENT4A/B in hepatovirus RNA synthesis, and suggest that TENT4A/B inhibitors may be useful for preventing or treating hepatitis A in humans.
The effects of using two varieties of one language on cognition
Authors: Alrwaita Najla , Houston-Price Carmel , Pliatsikas Christos 
Published: July 2022

Abstract
Although the question of whether and how bilingualism affects executive functions has been extensively debated,
less attention has been paid to the cognitive abilities of speakers of different varieties of the same language, in linguistic
situations such as bidialectalism and diglossia. Similarly to the bilingual situation, in bidialectalism and diglossia speakers
have two language varieties that are active at the same time. However, these situations have been argued to potentially provide
varied, and possibly fewer, opportunities for mixing or switching between the varieties, which may in turn lead to different
cognitive outcomes than those reported in bilingualism. Here we review the available evidence on the effects of bidialectalism and
diglossia on cognition, and evaluate it in relation to theories of the effects of bilingualism on cognition. We conclude that
investigations of bilingualism, bidialectalism and diglossia must take into account the conversational context and, in particular,
the opportunities for language switching that this affords.