bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect Of The ABCA1 Agonist CS-6253 On Amyloid β And Lipoproteins Metabolism In Cynomolgus Monkeys.
Authors: Noveir Sassan D. , Kerman Bilal E. , Xian Haotian , Meuret Cristiana , Smadi Sabrina , Martinez Ashley E. , Johansson Johannes , Zetterberg Henrik , Parks Bryan A. , Kuklenyik Zsuzsanna , Johansson Jan O. , Yassine Hussein N. 
Published: February 2022

Abstract
Background: Inducing brain ATP binding cassette 1 (ABCA1) activity in Alzheimer’s disease (AD) mouse models is associated with improvement in AD pathology. The purpose of this study was to investigate the effects of the ABCA1 agonist peptide CS-6253 on amyloid-β peptides (Aβ) and lipoproteins in plasma and cerebrospinal fluid (CSF) of cynomolgus monkeys, a species with amyloid and lipoprotein metabolism similar to humans. Methods: CS-6253 peptide was injected intravenously to cynomolgus monkeys at various doses in three different studies. Plasma and CSF samples were collected at several time points before and after treatment. Levels of cholesterol, triglyceride (TG), lipoprotein particles, apolipoproteins, and Aβ were measured using ELISA, ion-mobility analysis, and asymmetric-flow field-flow fractionation (AF4). The relationship between the change in levels of these biomarkers was analyzed using multiple linear regression models and linear mixed-effects models.Results: Following CS-6253 intravenous injection, within minutes, small, plasma high-density lipoprotein (HDL) particles were increased. In two independent experiments, plasma TG, apolipoprotein E (apoE), and Aβ42/40 ratio were transiently increased following CS-6253 intravenous injection. This change was associated with a non-significant decrease in CSF Aβ42. Both plasma total cholesterol and HDL-cholesterol levels were reduced following treatment. Using AF4 fractionation, CS-6253 treatment displaced apoE from HDL to intermediate-density- and low density-lipoprotein (IDL/LDL) sized particles in plasma. In contrast to plasma, CS-6253 had no effect on the assessed CSF apolipoproteins or lipids.Conclusions: These findings support that inducing systemic ABCA1 activity by CS-6253 shifts apoE into larger triglyceride-rich lipoprotein (TRL) particles that assist in Aβ clearance from the brain.
Flexible Conductive Nanocomposites for Electrochemical Devices Based on Chlorinated Natural Rubber/ Nickel Oxide Nanoparticles
Authors: Parvathi K. , Bahuleyan B. K. , Ramesan M.T. 
Published: February 2022

Abstract
A study on structural, thermal, temperature-dependent electrical properties such as AC conductivity and dielectric properties of flexible conductive chlorinated natural rubber (Cl-NR) were carried out with various contents of nickel oxide (NiO) nanoparticles. The role of fillers on DC conductivity of the composites was correlated with different theoretical models. The FT-IR spectra showed the characteristic absorption band for nano-NiO in the rubber indicating the effective incorporation of nanoparticles in Cl-NR. Optical bandgap energy was observed minimum for 5 phr loaded composite. TGA result showed that the thermal stability increased with NiO content in the polymer matrix. The dielectric properties and AC electrical conductivity increased significantly with the temperatures and also with the addition of nanoparticles up to 5 phr loading. The activation energy of the electrical conductivity decreases with an increase in temperature for all the systems. The higher value of dielectric permittivity explained the electrode polarisations at low-frequency region. The skewed semi-circular arc in the Cole-Cole plot observed for all the samples explained the semiconducting behaviour of the nanocomposites. Space charge polarisation and relaxation dynamics of Cl-NR composites were explained based on modulus spectra. The McCullough model was found to be the most promising one to explain the DC conductivity of the system which emphasizes the importance of interfacial interaction at the boundary of filler and the rubber chain for the network formation. According to the results of this study, these samples can be used in highly durable flexible electronic devices such as conductive sensors, actuators and super-capacitors.
Knowledge, Attitude and Behaviour Towards Recommended Vaccines Among Medical Students in Multan, Pakistan.
Authors: Mustafa Abdul Mannan , Zainab Anika , Rasheed Muhammad Haroon ul , Bilal Ahmed , Barki Wajid Hussain , Mustafa Ghulam , Khar Usama 
Published: February 2022

Abstract
Objective
To evaluate the knowledge, attitude and behavior of medical students towards recommended vaccines.
Method
A cross sectional study was done, where 3000 students from medical colleges of Multan were included by convenience sampling. They filled a well-developed, pretested questionnaire through Google forms and the results were analyzed by the Google forms itself.
Results
Mostly (69%) think they have adequate knowledge related to vaccination and that vaccines are effective for prevention (93%) of diseases. Almost 82% were of the opinion that vaccines are safe. Mostly (83%) believe that benefits of vaccines are greater. Majority (86%) think the unvaccinated people are at risk. Only 25% said they trust the information regarding vaccines acquired from society. Most (91%) think that one should get vaccinated according to the recommended vaccination plan and even 86% said one should get vaccinated even if it is not free. Some (59%) said the route of administration matters. Majority (68%) think there should be an aggressive law enforcement action to get vaccinated. Almost all of them (93%) think that medical students should persuade others for vaccination and 83% of them agreed that they’d consider to take part in any campaign/ program for vaccination.
Conclusion
It has been found that medical students from all years have sufficient knowledge related to vaccination and show a positive attitude towards vaccination. Medical students can be used as a means for spreading awareness regarding infectious diseases and their prevention. We recommend medical institutes conduct workshops and introduce programs that can help to educate students on infectious diseases and vaccination.
An Econometric Analysis of FDNY’s Systemwide EMS Dispatch, Response and Operational Performance During the 2020 Covid Lockdown Using a Negative Binomial Model With Multiple Fixed Effects
Authors: Pitt Ivan L. 
Published: February 2022

Abstract
A negative binomial longitudinal (panel) count model with multiple fixed effects in the presence of over-dispersion is used to estimate the heterogenity effects of emergency 911 incidents or call volume, year, day of the week, dispatcher-assigned medical emergency call type, priority rank, ambulance (DUAL, ALS, BLS) response and borough on average ambulance travel time. We use FDNY Emergency Dispatch Data for the periods March 20, 2019–June 13, 2019 and the corresponding lockdown period of March 20, 2020–June13, 2020 for a year over year econometric analysis. The model addresses the limitations of two-by-two contingency table analysis when there are more than two categorical variables by utilizing the underlying statistical properties of the Poisson distribution in a multivariate parametric approach by analyzing the simultaneous effects of several explanatory variables.When clustered standard errors are corrected for fixed effects and over-dispersion, we find that there was no significant statistical difference in the relationship between average travel time and call volume in the 2019 and 2020 periods. Wednesday is only day of the week that was most likely to increase travel response time. All medical emergencies showed significant declines in average travel response time at a p-value = .05, except for call types designated as allergy that was significant at p-value less than .07. Clinical priority rank 6 that required the use of BLS equipment and EMT crews used in non-medical emergencies and other cases had no statistical effect on travel time in the comparison. When compared to Manhattan, Brooklyn and Queens had no significant statistical effect on average travel response time.
Male Differentiation in the Marine Copepod Oithona Nana Reveals the Development of a New Nervous Ganglion Linked to Lin12-Notch-Repeat Protein-Associated Proteolysis
Authors: Sugier Kevin , Laso-Jadart Romuald , Vacherie Benoit , Käfer Jos , Bertrand Laurie , Labadie Karine , Martins Nathalie , Orvain Celine , Petit Emmanuelle , Poulain Julie , Wincker Patrick , Jamet Jean-Louis , Alberti Adriana , Madoui Mohammed-Amin 
Published: February 2022

Abstract

Background
Copepods are among the most numerous animals, and play an essential role in the marine trophic web and biogeochemical cycles. The genus Oithona is described as having the highest density of copepods, and as being the most cosmopolite copepods. The Oithona male paradox describes the activity states of males, which are obliged to alternate between immobile and mobile phases for ambush feeding and mate searching, respectively, while the female is typically less mobile and often feeding. To characterize the molecular basis of this sexual dimorphism, we combined immunofluorescence, genomics, transcriptomics, and protein-protein interaction approaches.
Results
Immunofluorescence of β3- and α-tubulin revealed two male-specific nervous ganglia in the lateral first segment of the Oithona nana male’s prosome. In parallel, transcriptomic analysis showed male-specific enrichment for nervous system development-related transcripts. Twenty-seven Lin12-Notch Repeat domain-containing protein coding genes (LDPGs) of the 75 LDPGs identified in the genome were specifically expressed only in males. Furthermore, most of the LDPGs (27%) coded for proteins having predicted proteolytic activity, and non-LDPG proteolysis-associated transcripts showed a male-specific enrichment. Using yeast double–hybrid assays, we constructed a protein-protein interaction network involving two LDPs with proteases, extracellular matrix proteins, and neurogenesis-related proteins.
Conclusions
For the first time, our study describes the lateral nervous ganglia of O. nana males, unique to copepods. We also demonstrated a role of LDPGs and their associated proteolysis in male-specific physiology, and we hypothesize a role of the LDPGs in the development of the lateral ganglia through directed lysis of the extracellular matrix for the growth of neurites and genesis of synapses.
The Impact of the COVID-19 Pandemic on a PICU in China that did not Admit COVID-19 Patients: A Retrospective Study
Authors: Zhang Geng , Zhang Xuepeng , Zhou Yue , Yao Hua , Yang Kaiying , Gong Xue , Zhou Jiangyuan , Qiu Tong , Ji Yi , Chen Siyuan 
Published: February 2022

Abstract
BackgroundThe unprecedented COVID-19 pandemic has been spreading for more than one and a half years. However, it is unclear whether the pandemic influenced admission in pediatric intensive care units (PICUs) that never received COVID-19 patients during the early major outbreak in China.MethodsA retrospective study was conducted in a PICU in a tertiary hospital in Chengdu, southwestern China. We sought to describe the trend of admission number from pre-epidemic years (2018 and 2019) to 2021. We explored the impact of the COVID-19 outbreak on PICU admission characteristics by including all patients younger than 18 years admitted to the PICU between January 23 and April 8 in 2020 and those admitted in the same time periods in pre-epidemic years and in 2021.ResultsThe percentage of patients admitted to the PICU from the Chengdu region increased from 34.2 percent in 2019 to 40.4 percent in 2020, whereas that from other provinces decreased from 11.7 percent in 2019 to 5.8 percent in 2020 (P = 0.012). The median length of stay (LOS) in the PICU was significantly longer in the 2020 cohort (4.0 days) than in the 2019 cohort (2.0 days) (P <0.001); the median hospital LOS was also significantly longer in the former (12.0 days) than in the latter (8.0 days) (P < 0.001). Both hospital outcomes (P = 0.005) and primary diagnosis distributions (P = 0.025) between the 2020 and 2019 cohorts were significant.ConclusionsIn a PICU that never received COVID-19 patients, the onset of the 2020 major outbreak was accompanied by changes in the composition of regions of patients, longer PICU and hospital stays, an increased proportion of unauthorized discharge and death, and a larger proportion of neoplasms, nervous system diseases and injury.
Enhanced Resource Allocation in Vehicular Adhoc Networks using Colonel Blotto Game Model
Authors: M Bhuvaneswari , B Paramasivan , B Shunmugapriya 
Published: February 2022

Abstract
In Vehicular Adhoc Networks (VANETs), collaboration and coordination between mobile nodes (vehicles) and static nodes (roadside infrastructure) are significant. The great challenges of the VANETs are rapid changes of topology, perceiving and transmitting of physical environment parameters. Because of the lack of central coordinator and the selfishness of the vehicles, effective routing is a challenging task in VANETs. Optimal resource allocation is quite essential to achieve an effective routing. Game theoretical models have currently used as a tool bring fairness among the resources utilization and users. This work proposes an approximation Colonel Blotto Game (CBG) model to analyse the possible strategy set for each player in allocating resources. We have calculated the payoff to nodes for motivating the players those who are involved in the routing process. A generalization of CBG has enabled to derive deterministic and implementable equilibrium strategies. The existence of Nash equilibrium (NE) for pure strategy has proven. The proposed work has also found out the optimal strategies by introducing a method of Lagrange multipliers. Experimental results show that the proposed CBG based resource allocation scheme could significantly allocate the resources fairly to forward the packet thereby it enhances the routing.
Correlation Among Writing Theory, Motivation And Writing Practice Of Trdinanti University Students
Authors: TRIDINANTI GAYA , RONI RUSMAN , SARI FARNIA , NURULANNINGSIH NURULANNINGSIH 
Published: February 2022

ABSTRACT : The purpose of this study to determine the correlation among writing theory, writing motivation and the writing practice of narrative text. The method used is survey with correlational techniques. The analytical method used is correlational analysis. The population is all students of English Department. The sample is 75 students with total sampling technique. The result shows that (1) there is significant correlation between Writing Theory and Writing Practice, proven by t value = 5.579 and Sig0.000 <0.05;(2) there is significant correlation between Writing Motivation and Writing Practice, proven by t value = 2.167 and Sig. 0.000 <0.05; (3) there is significant contribution of Writing Theory and Writing Motivation toward Writing Practice, proven by Fo = 64.936 and Sig. 0.000 <0.05. It can be concluded that the writing practice of narrative text is correlated by writing theory and writing motivation both partially and simultaneously.

Keywords: motivation, narrative text, practice, theory, writing
Students’ Perceptions in a Diverse Language Classroom: The Case of One Public University in Indonesia
Authors: Wahyuni Anggraini Hesti , Hayati Rita , Lingga Pitaloka Nova 
Published: February 2022

Diversity in language learning classrooms is important subject to study. Diversity affects students’ viewpoints and their success in language learning. Diversity does not exist without challenges; therefore, the emphasis here explored how diversity appeared and how the students accommodated the diversity to promote learning goals. This paper presented students ' perception of diversity in an English language classroom at one public university in Indonesia. This exploratory study aimed to better understand diversity to meet students’ needs. By conducting a survey, the questionnaire and interview aimed to collect information about (a) demographic data (age, gender, and nationalities), but not limited to students’ level, culture and socioeconomic status, (b) students’ viewpoints about diversity and (c) how to accommodate the differences. The result showed that positive viewpoints referred to cultural awareness, knowledge acquisition and relationship while negative one referred to the difficulty to tolerate differences. Some recommendations are derived from the results.
The Key Determinants of Social Media Use in Teaching during the Covid-19 Outbreak: Indonesia Case
Authors: Yuliana Lia , Prasojo Lantip Diat , Wijayanti Wiwik , Wijaya Widia Murni 
Published: February 2022

This study aims to provide empirical evidence on how higher education institutions (HEIs) teacher educators use SM in teaching during the Corona Virus Disease (Covid-19) outbreak. Evaluation of the factors that are the key to implementing the use of SM in education during the Covid-19 outbreak is essential. We used a survey aiming to answer the research questions of the study. The study participants are 297 faculty members from all over the Indonesian faculty of education and teacher training. The findings of the study reported that all hypotheses are significant. Facilitating Condition (FC) significantly predicts Perceived Ease of Use (PEU) and Perceived Usefulness (PU). Similarly, PEU is positively related to PU and Intention to Use (IU). PU also significantly determines IU. In addition, IU is significantly correlated with Actual Use (AU). The highest path coefficient is achieved by the relationship between the FC and PU. PEU and PU are the lowest relationship. Suggestions and recommendations are offered for the betterment of teaching and learning processes during the Covid-19 outbreak.
Educational Leader’s Adversity Quotient, Management Style, and Job Performance: Implications to School Leadership
Authors: Anne Tansiongco Louisa , Ibarra Florante 
Published: February 2022

The study examined the adversity quotient, school management style and job performance of public elementary school heads in Cabanatuan City, Philippines. Total population sampling was utilized among 38 public elementary school heads in the district. Anchored on Adversity Quotient Theory (Stoltz, 2000) and Situational Leadership Theory (Hersey & Blanchard, 2001), both processes measured how educational leader reacts and resolves within tough school related problems encountered. These lenses offered structure in looking at the four dimensions of adversity quotient in relation to leadership style. Survey questionnaire on Adversity Response Profile (ARP), Leadership Style, and Office/Individual Performance Commitment Response (OPCR) were utilized. With two-semester period of data consolidation, Pearson r product moment correlation assisted in the analysis of data. Results disclosed that, in adversity quotient and job performance, school heads having high degree of adversity quotient- control most likely to perform better in instructional leadership and quality standard for basic education program. Recommendations on the opportunity of assimilating adversity quotient and school management style in their current school head qualifications be considered to further improve organizational performance in the educational management system.
Rancang Bangun Sistem Monitoring Arus Bocor Isolator
Authors: Indah Amelya , Hulukati Stephan Adriansah , Yusrianto Malago  , Yusrianto Malago  
Published: February 2022

Salah satu peralatan penting dalam sistem ketenagalistrikan adalah isolator yang berfungsi sebagai penyekat bagian bertegangan dan tidak bertegangan agar tidak terjadi aliran listrik yang berdampak pada pemadaman listrik, kebakaran dan korban jiwa. Penelitian ini bertujuan untuk merancangg sistem monitoring arus bocor isolator menggunakan sensor arus CST013 dan nodeMCU ESP8266 dan Thingspeak sebagai media monitor arus bocor yang terukur. Metode penelitian dimulai dari perancangan sistem, pembuatan prototipe, pengujian isolator dengan tegangan tinggi AC mulai dari 5 kV sampai terjadi flashover pada isolator uji. Pembacaan arus bocor oleh sensor dibandingkan dengan hasil pembacaan arus oleh multimeter. Sensor arus mulai mendeteksi arus bocor pada menit 17:41:24 sebesar 0,001 pada tegangan uji 35kV dan nilainya semakin meningkat sebanding besarnya tegangan uji dan lamanya pengujian isolator. Arus bocor tertinggi yang terukur oleh sensor terjadi pada saat isolator mengalami flashover yakni sebesar 1,932 Ampere pada tegangan uji 70kV. Selisih pembacaan arus oleh sensor dan multimeter pada masing-masing tegangan uji 30 kV, 50 kV, 70 kV adalah 0,032 A, 0,108 A, 0,310 A.
Glossophobia among Engineering Learners: A Case Study at a Technical University
Authors: Balakrishnan Subatira , Abdullah Norlisa Loke , Khoo Mei Sui Linda 
Published: February 2022

Abstract: Glossophobia or fear of public speaking is commonly experienced by tertiary learners during classroom presentations. This study intends to examine the speech anxiety level experienced by engineering learners and the relationship between the learners’ English language proficiency and their speech anxiety. The study will also identify the causes of public speaking anxiety among these engineering learners. The samples were 65 Engineering Diploma students who responded to McCroskey’s Personal Report of Public Speaking Anxiety (PRPSA) questionnaire. The students’ English language grades at SPM level were used as the measurement of their English language proficiency. The findings showed the students’ speech anxiety is at moderate level (M= 105.9) and there was a weak negative relationship between total PRPSA scores and SPM English language grades (r = -.149, n = 65, p > 0.05). Mere thoughts of presenting a speech with undue worries of being asked questions were the causes of their speech anxiety. Therefore, it is proposed engineering learners be given ample public speaking trainings through planned programmes and engineering curriculum planners include elements of public speaking in engineering subjects. Public speaking skills will be an added value and increase engineering graduate employability in future.
Keywords: Communication apprehension, Glossophobia, Public speaking, Speech anxiety, PRPSA
Application of Fuzzy Mathematics Calculation in Quantitative Evaluation of Students’ Performance of Basketball Jump Shot
Authors: Qu Lianzhu , Katib Iyad , Aouad Marwan 
Published: February 2022

Abstract

Objective
To explore the application of fuzzy mathematics calculation in quantitative evaluation of students’ basketball jump shot performance.

Methods
Using the basic theory of fuzzy mathematics and the calculation method of fuzzy correlation, the correlation degree between the training means and the free throw hit rate was obtained, and further, the best training means to improve the free throw hit rate of basketball players were selected. As a result, when the ball reaches the highest point or falls after reaching the highest point, it is pushed out towards the 45° Angle, making the basketball fly to the basket in an arc. The jump shot is designed to avoid being blocked by a defender and is very effective against players of similar size or when no one is guarding.

Conclusion
The method proposed in this paper is suitable for the evaluation of college basketball teaching and ball skill training, and provides theoretical basis and quantitative data for training.