bluuebunny/crossref_metadata_2025_split huggingface dataset:
Existence of matching priors on compact spaces
Authors: Duanmu Haosui , Roy Daniel M , Smith Aaron 
Published: November 2022

SummaryA matching prior at level $1-\alpha$ is a prior such that an associated $1-\alpha$ credible region is also a $1-\alpha$ confidence set. We study the existence of matching priors for general families of credible regions. Our main result gives topological conditions under which matching priors for specific families of credible regions exist. Informally, we prove that, on compact parameter spaces, a matching prior exists if the so-called rejection-probability function is jointly continuous when we adopt the Wasserstein metric on priors. In light of this general result, we observe that typical families of credible regions, such as credible balls, highest-posterior density regions, quantiles, etc., fail to meet this topological condition. We show how to design approximate posterior credible balls and highest-posterior density regions that meet these topological conditions, yielding matching priors. Finally, we evaluate a numerical scheme for computing approximately matching priors based on discretization and iteration. The proof of our main theorem uses tools from nonstandard analysis and establishes new results about the nonstandard extension of the Wasserstein metric that may be of independent interest.
Relatedness dynamics and sex-biased dispersal in a seasonal cycle of corn mice from intensively managed agroecosystems
Authors: Sommaro Lucia V , Martínez Juan J , Chiappero Marina B , Steinmann Andrea R , Gardenal Cristina N , Priotto José W 
Published: November 2022

Abstract
The sex-biased dispersal and kinship dynamics are important factors shaping the spatial distribution of individuals and are key parameters affecting a variety of ecological and evolutionary processes. Here, we studied the spatial distribution of related individuals within a population of corn mice Calomys musculinus in a seasonal cycle to infer dispersal patterns. The sampling was carried out from spring 2005 to winter 2006 in field borders of intensively managed agroecosystems. Genotyping data from 346 individuals with 9 microsatellites showed spatial genetic structure was weak for males, but not for females. The results indicate a complex spatial kinship dynamic of related females across all seasons. Which, contrary to our expectations, dispersal distances decrease with the increase of the population abundance. Meanwhile, male dispersal distances were greater when population abundance increased and thus the availability of active females. Males disperse greater distances to mate and sire offspring with distant females as a possible inbreeding avoidance mechanism. This study shows that C. musculinus is capable of much greater scattering distances than previously reported and that dispersal occurs fluidly and without barriers across the agroecosystem. The indirect benefit of dispersal on individual fitness could be related to relaxing the competition in the natal area and increasing the mating rate. Our study highlights the value of combining genetic relatedness, fieldwork observations, and behavioral data to estimate dispersal at a fine geographical scale.
Acinetobase: the comprehensive database and repository of Acinetobacter strains
Authors: Valcek Adam , Collier James , Botzki Alexander , Van der Henst Charles 
Published: November 2022

Abstract
Acinetobacter baumannii is one of the most problematic nosocomial pathogens that can efficiently thrive within hospital settings, mainly due to resistances toward antibiotics, desiccation, disinfectants, human serum and oxidative stress. Recently, increased resistance against last-resort antibiotics earns this bacterium the highest priority concern classified by the Centers for Disease Control and Prevention and the World Health Organization. An obvious hallmark of this bacterium is the high heterogeneity observed among A. baumannii isolates, with a limited core genome. This feature complexifies the study of A. baumannii bacteria as an entity, subsequently reflected in a diversity of phenotypes of not only antimicrobial and environmental resistance but also virulence. A high degree of genome plasticity, along with the use of a limited subset of established strains, can lead to strain-specific observations, decreasing the global understanding of this pathogenic agent. Phenotypic variability of A. baumannii strains is easily observable such as with the macrocolony morphologies, in vitro and in vivo virulence, natural competence level, production of different capsular polysaccharide structures and cellular densities. Some strains encode several virulence factors, while others, including the established strains, lack key ones. The lack/excess of genes or specific physiological processes might interfere with in vivo and in vitro experiments, thus providing a limited impact on the global understanding of Acinetobacter bacteria. As an answer to the high heterogeneity among A. baumannii strains, we propose a first comprehensive database that includes the bacterial strains and the associated phenotypic and genetic data. This new repository, freely accessible to the entire scientific community, allows selecting the best bacterial isolate(s) related to any biological question, using an efficient and fast exchange platform.
Database URL: https://acinetobase.vib.be/
Comparing latent inequality with ordinal data
Authors: Kaplan David M , Zhao Wei 
Published: November 2022

Summary
We propose new ways to compare two latent distributions when only ordinal data are available, and without imposing parametric assumptions on the underlying continuous distributions. First, we contribute identification results. We show how certain ordinal conditions provide evidence of between-group inequality, quantified by particular quantiles being higher in one latent distribution than in the other. We also show how other ordinal conditions provide evidence of higher within-group inequality in one distribution than in the other, quantified by particular interquantile ranges being wider in one latent distribution than in the other. Second, we propose an ‘inner’ confidence set for the quantiles that are higher for the first latent distribution. We also describe frequentist and Bayesian inference on features of the ordinal distributions relevant to our identification results. Our contributions are illustrated by empirical examples with mental health and general health.
Individualized exercise prescription and cardiac rehabilitation following a spontaneous coronary artery dissection or aortic dissection
Authors: Van Iterson Erik H , Laffin Luke J , Svensson Lars G , Cho Leslie 
Published: November 2022

AbstractAimsPrescribed aerobic-based exercise training is a low-risk fundamental component of cardiac rehabilitation (CR). Secondary prevention therapeutic strategies following a spontaneous coronary artery dissection (SCAD) or aortic dissection (AD) should include CR. Current exercise guidance for post-dissection patients recommends fundamental training components including target heart rate zones are not warranted. Omitting fundamental elements from exercise prescriptions risks safety and makes it challenging for both clinicians and patients to understand and implement recommendations in real-world practice. We review the principles of exercise prescription for CR, focusing on translating guidelines and evidence from well-studied high-risk CR populations to support the recommendation that exercise testing and individualized exercise prescription are important for patients following a dissection.Methods and resultsWhen patients self-perceive exercise intensity there is a tendency to underestimate intensities within metabolic domains that should be strictly avoided during routine exercise training following a dissection. However, exercise testing associated with CR enrolment has gained support and has not been linked to adverse events in optimally medicated post-dissection patients. Graded heart rate and blood pressure responses recorded throughout exercise testing provide key information for developing an exercise prescription. An exercise prescription that is reflective of medical history, medications, and cardiorespiratory fitness optimizes patient safety and yields improvements in blood pressure control and cardiorespiratory fitness, among other benefits.ConclusionThis clinical practice and education article demonstrates how to develop and manage a CR exercise prescription for post-acute dissection patients that can be safe and effective for maintaining blood pressure control and improving cardiorespiratory fitness pre–post CR.
Availability of virtual-assisted lung mapping affects procedure selection for early-stage lung cancer: a web-based cross-sectional study
Authors: Yamaguchi Hirokazu , Sato Masaaki , Yamamoto Kazumichi , Shinohara Kiyomi , Yanagiya Masahiro , Hashisako Mizuho , Wannous Muhammad , Nakajima Jun 
Published: November 2022

Abstract

OBJECTIVES
The availability of new techniques may affect surgeons’ procedure selection and thereby affect clinical outcomes. This study aimed to evaluate the effect of the availability of virtual-assisted lung mapping (VAL-MAP) on the selection of lung resection methods.

METHODS
Members of the Japanese Association for Chest Surgeons were invited to participate in a web-based survey. Participants were divided into those who had never used VAL-MAP (group 0), those who had used only VAL-MAP 1.0 (multiple dye marks on the pleural surface; group 1) and those who had used VAL-MAP 2.0 (multiple dye marks and intrabronchial microcoils for three-dimensional mapping; group 2). Participants were shown chest computed tomography images of 6 ground-glass opacity nodules and asked to choose surgical procedures to resect the nodules with sufficient resection margins greater than the lesion diameter or 2 cm.

RESULTS
There were 197 surgeons in group 0, 49 in group 1 and 26 in group 2. All groups showed a similar trend of avoiding wedge resection for deeply located nodules. However, group 1 showed a trend of disagreeing with the selection of wedge resection compared with group 0 as measured by a Likert scale (1–5) by −0.21 points (95% confidence interval, −0.41 to −0.008 points, P = 0.042). This tendency disappeared in group 2.

CONCLUSIONS
The availability of VAL-MAP 1.0 led to the selection of segmentectomy, while the availability of VAL-MAP 2.0 led to aggressive deep wedge resection.
Conduction system pacing in everyday clinical practice: EHRA physician survey
Authors: Kircanski Bratislav , Boveda Serge , Prinzen Frits , Sorgente Antonio , Anic Ante , Conte Giulio , Burri Haran 
Published: November 2022

AbstractWith the increasing interest in conduction system pacing (CSP) over the last few years and the inclusion of this treatment modality in the current guidelines, our aim was to provide a snapshot of current practice across Europe. An online questionnaire was sent to physicians participating in the European Heart Rhythm Association research network as well as to national societies and over social media. Data on previous experience with CSP, current indications, preferred tools, unmet needs, and perceptions for the future are reported and discussed.
P-wave duration and atrial fibrillation recurrence after catheter ablation: a systematic review and meta-analysis
Authors: Intzes Stergios , Zagoridis Konstantinos , Symeonidou Marianthi , Spanoudakis Emmanouil , Arya Arash , Dinov Borislav , Dagres Nikolaos , Hindricks Gerhard , Bollmann Andreas , Kanoupakis Emmanuel , Koutalas Emmanuel , Nedios Sotirios 
Published: November 2022

AbstractAimsAtrial fibrillation (AF) is a global health problem with high morbidity and mortality. Catheter ablation (CA) can reduce AF burden and symptoms, but AF recurrence (AFr) remains an issue. Simple AFr predictors like P-wave duration (PWD) could help improve AF therapy. This updated meta-analysis reviews the increasing evidence for the association of AFr with PWD and offers practical implications.Methods and resultsPublication databases were systematically searched and cohort studies reporting PWD and/or morphology at baseline and AFr after CA were included. Advanced interatrial block (aIAB) was defined as PWD ≥ 120 ms and biphasic morphology in inferior leads. Random-effects analysis was performed using the Review Manager 5.3 and R programs after study selection, quality assessment, and data extraction, to report odds ratio (OR) and confidence intervals. : Among 4175 patients in 22 studies, 1138 (27%) experienced AFr. Patients with AFr had longer PWD with a mean pooled difference of 7.8 ms (19 studies, P &lt; 0.001). Pooled OR was 2.04 (1.16–3.58) for PWD &gt; 120 ms (13 studies, P = 0.01), 2.42 (1.12–5.21) for PWD &gt; 140 ms (2 studies, P = 0.02), 3.97 (1.79–8.85) for aIAB (5 studies, P &lt; 0.001), and 10.89 (4.53–26.15) for PWD &gt; 150 ms (4 studies, P &lt; 0.001). There was significant heterogeneity but no publication bias detected.ConclusionP-wave duration is an independent predictor for AF recurrence after left atrium ablation. The AFr risk is increasing exponentially with PWD prolongation. This could facilitate risk stratification by identifying high-risk patients (aIAB, PWD &gt; 150 ms) and adjusting follow up or interventions.
Overexpression of miR390b promotes stem elongation and height growth in Populus
Authors: Shi Qiaofang , Tian Dongdong , Wang Jieyu , Chen Aoli , Miao Yuqing , Chen Yiming , Li Jun , Wu Xiaomeng , Zheng Bo , Guo Wenwu , Shi Xueping 
Published: November 2022

Abstract
MicroRNA390 (miR390) is involved in plant growth and development by down-regulating the expression of the downstream genes trans-acting short interfering RNA3 (TAS3) and AUXIN RESPONSE FACTORs (ARFs). There is a scarcity of research on the involvement of the miR390-TAS3-ARFs pathway in the stem development of Populus. Here, differentially expressed miRNAs during poplar stem development were screened by small RNA sequencing analysis, and a novel function of miR390b in stem development was revealed. Overexpression of miR390b (OE-miR390b) resulted in a large increase in the number of xylem fiber cells and a slight decrease in the cell length at the longitudinal axis. Overall increases in stem elongation and plant height were observed in the OE-miR390b plants. According to transcriptome sequencing results and transient co-expression analysis, TAS3.1 and TAS3.2 were identified as the target genes of miR390 in poplar and were negatively regulated by miR390 in the apex. The transcription levels of ARF3.2 and ARF4 were significantly repressed in OE-miR390b plants and strongly negatively correlated with the number of xylem fiber cells along the longitudinal axis. These findings indicate that the conserved miR390-TAS3-ARFs pathway in poplar is involved in stem elongation and plant height growth.
At odds: How intraprofessional conflict and stratification has stalled the Ontario paramedic professionalization project
Authors: Brydges Madison , Dunn James R , Agarwal Gina , Tavares Walter 
Published: November 2022

AbstractHistorically, self-regulation has provided some professions with power and market control. Currently, however, governments have scrutinized this approach, and priorities have shifted toward other mandates. This study examines the case of paramedics in Ontario, Canada, where self-regulation is still the dominant regulatory model for the healthcare professions but not for paramedics. Instead, paramedics in Ontario are co-regulated by government and physician-directed groups, with paramedics subordinate to both. This paper, which draws on interviews with paramedic industry leaders analyzed through the lens of institutional work, examines perspectives on the relevance of self-regulation to the paramedic professionalization project. Participants had varying views on the importance of self-regulation in obtaining professional status, with some rejecting its role in professionalization and others embracing regulatory reform. Because paramedics disagree on what being a profession means, the collective professionalization project has stalled. This research has implications for understanding the impact of intraprofessional relationships and conflict on professionalization projects.
The Right to a Favor: International Scholarships, Clientelism, and the Class Politics of Merit in Post-Revolutionary Mexico
Authors: Newman Rachel Grace 
Published: November 2022

Abstract
This article considers the ways that middle-class and elite citizens in post-revolutionary Mexico pursued access to exclusive favors from the state in the 1920s and 1930s and emphasizes the overlooked role of merit as political logic in this era. Examining political discourse within clientelist exchanges through the close reading of petitions, I explore ideas about class and nation as articulated by young strivers and their families who sought scholarships for foreign study. The article argues that working within clientelism, upwardly mobile Mexicans strategically wielded merit to preserve and legitimate their status amid social tectonic shifts. Petitioners’ ideas of merit encompassed individual loyalty and patriotism, unique talents, and inherited status. I identify heritable and disciplinary merit as distinct yet compatible understandings of worthiness used by privileged citizens. These citizens claimed that exceptional Mexicans trained abroad would make an outsized contribution to the national well-being and thus deserved special rewards, an argument which anticipated rationales that the Mexican state would later embrace for its modernization policy. After 1940, the state expanded international scholarship programs and invoked the same terms that citizens had used in the early post-revolutionary period to justify socially regressive benefits providing foreign education for the already fortunate.
Genetic enhancement: an avenue to combat aging-related diseases
Authors: Cai Yusheng , Ji Zhejun , Wang Si , Zhang Weiqi , Qu Jing , Belmonte Juan Carlos Izpisúa- , Liu Guang-Hui 
Published: November 2022

AbstractAging is a major risk factor for multiple diseases, including cardiovascular diseases, neurodegenerative disorders, osteoarthritis, and cancer. It is accompanied by the dysregulation of stem cells and other differentiated cells, and the impairment of their microenvironment. Cell therapies to replenish the abovementioned cells provide a promising approach to restore tissue homeostasis and alleviate aging and aging-related chronic diseases. Importantly, by leveraging gene editing technologies, genetic enhancement, an enhanced strategy for cell therapy, can be developed to improve the safety and efficacy of transplanted therapeutic cells. In this review, we provide an overview and discussion of the current progress in the genetic enhancement field, including genetic modifications of mesenchymal stem cells, neural stem cells, hematopoietic stem cells, vascular cells, and T cells to target aging and aging-associated diseases. We also outline questions regarding safety and current limitations that need to be addressed for the continued development of genetic enhancement strategies for cell therapy to enable its further applications in clinical trials to combat aging-related diseases.
A study of the hydrostatic mass bias dependence and evolution within The Three Hundred clusters
Authors: Gianfagna Giulia , Rasia Elena , Cui Weiguang , De Petris Marco , Yepes Gustavo , Contreras-Santos Ana , Knebe Alexander 
Published: November 2022

ABSTRACT
We use a set of about 300 simulated clusters from the three hundred Project to calculate their hydrostatic masses and evaluate the associated bias by comparing them with the true cluster mass. Over a redshift range from 0.07 to 1.3, we study the dependence of the hydrostatic bias on redshift, concentration, mass growth, dynamical state, mass, and halo shapes. We find almost no correlation between the bias and any of these parameters. However, there is a clear evidence that the scatter of the mass-bias distribution is larger for low-concentrated objects, high mass growth, and more generically for disturbed systems. Moreover, we carefully study the evolution of the bias of 12 clusters throughout a major-merger event. We find that the hydrostatic-mass bias follows a particular evolution track along the merger process: to an initial significant increase of the bias recorded at the begin of merger, a constant plateaus follows until the end of merge, when there is a dramatic decrease in the bias before the cluster finally become relaxed again. This large variation of the bias is in agreement with the large scatter of the hydrostatic bias for dynamical disturbed clusters. These objects should be avoided in cosmological studies because their exact relaxation phase is difficult to predict, hence their mass bias cannot be trivially accounted for.
Self-interacting superfluid dark matter droplets
Authors: Delgado Vicente , Muñoz Mateo Antonio 
Published: November 2022

ABSTRACT
We assume dark matter to be a cosmological self-gravitating Bose–Einstein condensate of non-relativistic ultralight scalar particles with competing gravitational and repulsive contact interactions and investigate the observational implications of such model. The system is unstable to the formation of stationary self-bound structures that minimize the energy functional. These cosmological superfluid droplets, which are the smallest possible gravitationally bound dark matter structures, exhibit a universal mass profile and a corresponding universal rotation curve. Assuming a hierarchical structure formation scenario where granular dark matter haloes grow around these primordial stationary droplets, the model predicts cored haloes with rotation curves that obey a single universal equation in the inner region ($r\, \lesssim \, 1$ kpc). A simultaneous fit to a selection of galaxies from the SPARC data base chosen with the sole criterion of being strongly dark matter dominated even within the innermost region, indicates that the observational data are consistent with the presence of a Bose–Einstein condensate of ultralight scalar particles of mass m ≃ 2.2 × 10−22 eV c−2 and repulsive self-interactions characterized by a scattering length as ≃ 7.8 × 10−77 m. Such small self-interactions have profound consequences on cosmological scales. They induce a natural minimum scale length for the size of dark matter structures that makes all cores similar in length (∼1 kpc) and contributes to lower their central densities.