bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association between quetiapine use and self-harm outcomes among people with recorded personality disorder in UK primary care: A self-controlled case series analysis
Authors: Hayes Joseph F , Hardoon Sarah , Deighton Jessica , Viding Essi , Osborn David PJ 
Published: November 2022

Background: Quetiapine is frequently prescribed to people with personality disorder diagnoses, but this is not supported by evidence or treatment guidelines. Aims: To examine associations between periods of quetiapine prescribing and self-harm events in people with personality disorder. Method: Self-controlled case series using linked primary care and hospital records covering the period 2007–2017. We calculated incidence rates and incidence rate ratios (IRRs) for self-harm events during periods when people were prescribed (exposed to) quetiapine, as well as periods when they were unexposed or pre-exposed to quetiapine. Results: We analysed data from 1,082 individuals with established personality disorder diagnoses, all of whom had at least one period of quetiapine prescribing and at least one self-harm episode. Their baseline rate of self-harm (greater than 12 months before quetiapine treatment) was 0.52 episodes per year. Self-harm rates were elevated compared to the baseline rate in the month after quetiapine treatment was commenced (IRR 1.85; 95% confidence interval (CI) 1.46–2.34) and remained raised throughout the year after quetiapine treatment was started. However, self-harm rates were highest in the month prior to quetiapine initiation (IRR 3.59; 95% CI 2.83–4.55) and were elevated from 4 months before quetiapine initiation, compared to baseline. Conclusion: Self-harm rates were elevated throughout the first year of quetiapine prescribing, compared to the baseline rate. However, rates of self-harm reduced in the month after patients commenced quetiapine, compared to the month before quetiapine was initiated. Self-harm rates gradually dropped over a year of quetiapine treatment. Quetiapine may acutely reduce self-harm. Longer-term use and any potential benefits need to be balanced with the risk of adverse events.
The effect of local cold application on intradialytic cramp: A quasi-experimental study
Authors: Akay Figen , Özkaraman Ayşe 
Published: November 2022

Aims: An intradialytic cramp, which frequently occurs in hemodialysis patients, is a disturbing condition. This study was conducted to evaluate the effect of local cold applications on the severity and duration of intradialytic cramps in patients with chronic kidney disease. Materials and Methods: This quasi-experimental study sample comprised of 74 patients who were aged >18 years, conscious, and reported experiencing intradialytic cramps in a dialysis center. In this study, the application group had the local cold treatment as well as the treatment recommended by the physician whereas the control group was only given the treatment recommended by the physician. The cramp severity was assessed using a visual analog scale as soon as the cramp started (T1) and 10 min after the onset of the cramp (T2). The cramp duration was determined by a chronometer. The Independent Sample T-test, One-Way ANOVA test, Paired Samples T-test and the Two-Way ANOVA test were used to analyze the data. Results: In the study, the duration of the cramp (sd) was 9.49 (0.86) minutes in the application group and 7.51 (0.69) minutes in the control group ( t = 1791, p = 0.078). It was determined that the pain severity scores of the application and control group patients were significantly decreased at the T2 time point compared to T1 ( p = 0.001), and the effect of the group and evaluation time points on the cramp severity score was not statistically different ( p = 0.548). Conclusion: In this study, the mean duration of the intradialytic cramp was below 10 min for both groups. The local cold application had no effect on cramp severity or duration.
Where Are All the Men? A Qualitative Review of the Barriers, Facilitators, and Recommendations to Older Male Participation in Health Promotion Interventions
Authors: Howell Britteny M. , Peterson Jennifer R. , Corbett Sage 
Published: November 2022

Objective Older men have lower participation rates than females in health promotion interventions. We conducted a qualitative review of 20 years of existing research across a variety of academic search databases to outline the barriers, facilitators, and recommendations for this imbalance. Data Source A systematic search was conducted across Google Scholar, PubMed, MEDLINE, CINAHL, Academic Search Premier, Psychology and Behavioral Sciences Collection, and Web of Science from dates January 1, 2000 – December 31, 2020. Study Inclusion and Exclusion Criteria Abstracts were screened based on: original research, English language, recruitment or participation, health promotion or health program, and male gender. Data Extraction Of 1194 initial search results, 383 article abstracts were thoroughly screened for inclusion and 26 articles met inclusion criteria. Synthesis Included studies were coded and analyzed using Grounded Theory. Results Barriers included masculine gender roles as well as program scope, environment, and gender of the instructors and other participants. Facilitators included creating social groups of older males that participate in a variety of activities together, including hobbies and health promotion, over a long period of time. Conclusion Health promotion interventions should involve men in all aspects of program planning and implementation, take into account men’s existing relationships and interests to create gender-sensitive programming, and clearly delineate the benefits to participation.
A preliminary exploration of different coping strategies used by Korean immigrant parents of autistic children in high versus low family quality of life ratings
Authors: Fong Vanessa C. , Shim Jennifer , Yoon Andy , Lee Bo Sang , Iarocci Grace 
Published: November 2022

The experiences of coping in parents of autistic children have been extensively studied in the literature. While this research has identified both effective and ineffective coping strategies used by caregivers, no studies to date have examined how coping strategies used by parents might be linked to family quality of life outcomes. Furthermore, few studies exist examining both coping strategies and family quality of life in culturally and linguistically diverse populations. Thus, this study aimed to address both limitations. A total of 12 Korean immigrant parents of autistic children, 6 representing the high family quality of life group and 6 representing the low family quality of life group, shared their experiences related to coping and managing stress. Responses fell under three broad categories (problem-focused, emotion-focused, and adjustment-focused) with differences observed when comparing the high versus low family quality of life groups. A better understanding of the link between coping strategies and family quality of life outcomes may help identify effective and culturally sensitive supports for caregivers and families to improve their quality of life and well-being. Lay abstract The experiences of coping in parents of autistic children have been extensively studied in the literature. While this research has identified both effective and ineffective coping strategies used by caregivers, no studies to date have examined how coping strategies used by parents might be linked to family quality of life outcomes. Furthermore, few studies exist examining both coping strategies and family quality of life in culturally and linguistically diverse populations. Thus, this study aimed to address both limitations. A total of 12 Korean immigrant parents of autistic children, 6 representing the high family quality of life group and 6 representing the low family quality of life group, shared their experiences related to coping and managing stress. Responses fell under three broad categories (problem-focused, emotion-focused, and adjustment-focused) with differences observed when comparing the high versus low family quality of life groups. A better understanding of the link between coping strategies and family quality of life outcomes may help identify effective and culturally sensitive supports for caregivers and families to improve their quality of life and well-being.
The Tree Drawing Test in Evolution: An Explorative Longitudinal Study in Alzheimer’s Disease
Authors: Stanzani Maserati Michelangelo , Matacena Marialaura , Baccari Flavia , Zenesini Corrado , Gallassi Roberto , Capellari Sabina , Matacena Corrado 
Published: November 2022

Objective To study the evolution of the Tree Drawing Test (TDT) in a group of Alzheimer’s disease (AD) patients. Methods A total of 33 AD patients were consecutively evaluated by Mini Mental State Evaluation (MMSE) and TDT. The evolution of the TDT parameters, trunk-to-crown (TC) and space occupation (SO) index, were analyzed. Results The median age at first visit was 79 years. Globally, trees drawn by patients showed an evolution characterized by a progressive reduction of the crown compared to the trunk. TC index showed a significant linear growth change (2.52 points per year) while SO index did not significantly increase. No significant associations were found examining the relations between MMSE and TC and SO index. Conclusions TDT could represent a complementary technique to the main neuropsychological screening tests for orienting cognitive impairment diagnosis and an aid in following the evolution of cognitive impairment over time in AD patients.
Moderate-to-Vigorous Physical Activity is Related With Retinal Neuronal and Axonal Integrity in Persons With Multiple Sclerosis
Authors: Kim Jeongwoon , Bollaert Rachel E. , Cerna Jonathan , Adamson Brynn C. , Robbs Connor M. , Khan Naiman A. , Motl Robert W. 
Published: November 2022

Background Moderate-to-vigorous physical activity (MVPA) may confer benefits for axonal and/or neuronal integrity in adults with multiple sclerosis (MS). Purpose Examine the association between device-measured MVPA with optical coherence tomography (OCT) metrics of retinal nerve fiber layer (RNFL) thickness and total macular volume (TMV) in persons with and without MS. Methods Adults with MS (N = 41), along with sex-matched healthy control (HC) participants (N = 79), underwent measurements of retinal morphology via OCT and wore an accelerometer for a period of 7 days as a measure of MVPA. Results Persons with MS had significantly lower MVPA, RNFL thickness, and TMV compared with HCs. MVPA was correlated with RNFL ( r = .38, P < .01) thickness and TMV ( r = .49, P < .01). Hierarchical linear regression analyses indicated that addition of MVPA attenuated the Group effect on RNFL and TMV. MVPA accounted for 8% and 3% of the variance in TMV (β = .343, P < .01) and RNFL thickness (β = .217, P = .03), respectively. Conclusion MVPA was positively associated with axonal and neuronal integrity assessed by OCT and partially explained group differences in those metrics. These results present possible future targets for MS management by increasing MVPA.
Outcome and Cost Comparisons Between Surgical and Transcatheter Aortic Valve Replacements
Authors: Falasa Matheus , Holmes Henry R. , Neal Daniel , Choi Calvin Y. , Park Ki , Bavry Anthony A. , Freeman Kirsten A. , Manning Eddie W. , Stinson Wade W. , Jeng Eric I. 
Published: November 2022

Objective: Surgical aortic valve replacement (SAVR) has been the standard of care for severe aortic stenosis. In 2019, annual transcatheter aortic valve replacement (TAVR) implantations surpassed SAVR. We compared in-hospital costs and outcomes between these two procedures. Methods: A single-center retrospective review was performed of patients who underwent isolated SAVR or TAVR from October 2013 to December 2019. Baseline patient characteristics, operating room (OR) time, intensive care unit (ICU) length of stay (LOS), total LOS, cumulative cost, and complication rates were collected. Propensity matching was performed to identify differences in costs and outcomes between comparable groups. Results: There were 515 patients who met inclusion criteria. TAVR was performed in 402 patients, while SAVR was performed in 113. Propensity matching resulted in 82 matched pairs. The SAVR cohort more frequently spent >1 day in the ICU, had longer total hospital LOS, longer OR time, and higher hospitalization cost. However, TAVR was associated with higher mean OR cost and higher valve cost. The cumulative index admission costs were not significantly different between groups. TAVR patients had less postoperative atrial fibrillation but more frequent pacemaker placement. One-year mortality was similar between SAVR (2.4%) and TAVR (3.8%), but 3-year (5.8% vs 19.2%) and 5-year (5.8% vs 37.2%) mortality favored SAVR. Conclusions: In propensity-matched groups, TAVR was associated with shorter ICU and hospital LOS and OR times but increased permanent pacemaker rates. In addition, while 1-year survival was similar between groups, SAVR had significantly improved 3-year and 5-year survival.
Power Lines, an Understudied Cause of Avian Mortality in Mexico
Authors: Escobar-Ibáñez Juan Fernando , Aguilar-López José Luis , Muñoz-Jiménez Oscar , Villegas-Patraca Rafael 
Published: November 2022

Background and Research Aims Power lines are one of the main anthropogenic causes of bird mortality on a global scale, but research is scarce in some countries with a high diversity of birds, such as Mexico. In this study, we assessed the impact of bird collisions and electrocutions with power lines on avian communities at three wind farms located in three different states in Mexico. Methods Carcass searches were carried out at sites in Tamaulipas (4 months in 2021), Guanajuato (2 months in 2020, 4 months in 2021), and Oaxaca (55 months from 2014 to 2021). Results A total of 579 bird carcasses from 65 different species were recorded. The White-winged Dove ( Zenaida asiatica) was the most frequently found species (282 records) across the three sites. When considering the number of species identified per family, Icteridae had the highest number of species at the Oaxaca site, Columbidae and Passerelidae at the Tamaulipas site, and Anatidae at the Guanajuato site. At the order level, Passeriformes had the highest number of species at the Tamaulipas and Oaxaca sites, and Anseriformes in Guanajuato. Of the total species recorded, 12 are within some category of risk according to Mexican legislation and the IUCN Red List, and 18 are migratory species. Conclusions Our results, together with evidence from previous studies, indicate that power lines represent one of the main causes of anthropogenic mortality in Mexico in terms of the number of affected bird species. Further research is urgently needed to explore the effect of power lines on bird populations in the country, particularly those at risk of extinction, and migratory species. Implications for Conservation The high diversity of species found to be affected in this study highlights the wide-ranging impact of these structures and the need to implement mitigation strategies at the three sites studied, particularly for the most affected species, the White-winged Dove ( Zenaida asiatica).
Reconstruction options in recurrent dermatofibrosarcoma protuberans:A scoping review
Authors: Mago Vishal , Pasricha Arush 
Published: November 2022

Background This review will outline the evaluation, diagnosis, and management of dermatofibrosarcoma protuberans and emphasizes multidisciplinary role of nurses, plastic surgeons and radiation oncologist in this recurrent metastatic lesion. It pinpoints affected population at risk, clinical features, and reconstruction options. No analytical research has been done in this area. Material and Methods A scoping review of patients of DFSP who underwent reconstruction after excision of tumors was performed in the Department of Burn and Plastic Surgery, AIIMS Rishikesh. It used a five framework approach. A review of 85 similar cases reported in the literature have been scrutinized in relation to the reconstruction options, sites of the tumor, margins of excision and recurrence. Results 85 full length English studies were included out of the 445 cases found in Pubmed and related search engines to reveal various reconstructive options in reconstruction of DFSP defects. Present scoping review identifies free anterolateral thigh flap to be useful in 7 review articles followed by propeller flaps in 3 isolated case reports. 2 cases of free latissimus dorsi flap were used for reconstruction of abdominal defects. Conclusion All patients should undergo a strict screening protocol where the health personnel can play a crucial role by educating parents on the follow up and report new lesions as early as possible. All operated tumor patients can be given safety tips and education on care and risks after reconstruction with skin flaps or skin grafting. A multidisciplinary approach between the surgeon, nurse and radiation oncologist is needed for effective management of these lesions.
Primary tracheal obstruction caused by adenoid cystic carcinoma during pregnancy: A case report
Authors: Xie Yongguo , Qin Ke , Du Xueke , Ming Shaopeng , Li Lianmei , Huang Chuangsheng 
Published: November 2022

The incidence of malignant tumors diagnosed during pregnancy is increasing, often ascribed to the recently recognized trend that many women are postponing childbirth. Although early diagnosis is optimal for both mothers and fetuses, the diagnosis of malignant tumors during pregnancy is often delayed until an advanced stage, because generalized symptoms of pregnancy and malignancy may overlap, such as shortness of breath, chest or abdominal discomfort. The study patient was 21 years old, and 31 weeks-pregnant when she was diagnosed with primary tracheal adenoid cystic carcinoma (ACC). The patient initially presented with dyspnea and decreased blood oxygen saturation and underwent a cesarean section on the first night of hospitalization, resulting from fetal distress. This case report intended to investigate potential barriers to the timely diagnosis of tracheal ACC and consider optimal management strategies when it is diagnosed during pregnancy.
Regional left atrial conduction velocity in the anterior wall is associated with clinical recurrence of atrial fibrillation after catheter ablation: efficacy in combination with the ipsilateral low voltage area
Authors: Ohguchi Shiou , Inden Yasuya , Yanagisawa Satoshi , Fujita Rin , Yasuda Kenichiro , Katagiri Ken , Oguri Mitsutoshi , Murohara Toyoaki 
Published: November 2022

Abstract
Background
Left atrial (LA) conduction velocity (CV) is an electrical remodeling parameter of atrial fibrillation (AF) substrate. However, the pathophysiological substrate of LA-CV and its impact on outcomes after catheter ablation for AF have not been well evaluated.

Methods
We retrospectively evaluated 119 patients with AF who underwent catheter ablation and electroanatomical mapping during sinus rhythm. To measure regional LA-CV, we took triplet sites (A, B, and C) on the activation map and calculated the magnitude of the matched orthogonal projection vector between vector-AB and vector-AC, indicating two-dimensional CV. The median of the LA-CVs from four triad sites in both the anterior and posterior walls was set as the ‘model LA-CV’. We evaluated the impact of the model LA-CV on recurrence after ablation and relationship between the model LA-CV and LA-low voltage area (LVA) of < 0.5 mV.

Results
During the 12-month follow-up, 29 patients experienced recurrence. The LA-CV model was significantly correlated with ipsilateral LVA. The lower anterior model LA-CV was significantly associated with recurrence, with the cut-off value of 0.80 m/s having a sensitivity of 72% and specificity of 67%. Multivariable analysis revealed that the anterior model LA-CV (hazard ratio, 0.09; 95% confidence interval, 0.01–0.94; p = 0.043) and anterior LA-LVA (hazard ratio, 1.06; 95% confidence interval, 1.00–1.11; p = 0.033) were independently associated with AF recurrence. The anterior LA-LVA was mildly correlated with the anterior model LA-CV (r = -0.358; p < 0.001), and patients with both lower LA-CV and greater anterior LA-LVA based on each cut-off value had the worst prognosis. However, decreased LA-CV was more likely to be affected by the distribution pattern of the LVA rather than the total size of the LVA.

Conclusion
Decreased anterior LA-CV was a significant predictor of AF recurrence and was a useful electrical parameter in addition to LA-LVA for estimating AF arrhythmogenicity.
Effect of low dose aspirin application during pregnancy on fetal congenital anomalies
Authors: Sun Si , Qian HongYang , Li Congcong , Wang Qiaohong , Zhao Aimin 
Published: November 2022

Abstract
Background
With the extensive use of aspirin in obstetrics and reproductive medicine, concerns of potentially related congenital anomalies have been raised in previous studies. However, there is a lack of evidence concerning the safety of application of aspirin during pregnancy in Chinese population, especially during the first trimester.

Patients and methods
We retrospectively included a total of 2,763 patients with 2,856 fetuses (2670 singleton births and 93 pairs of twins), among whom 1,684 took low dose aspirin (LDA) during pregnancy (the LDA group) and the other 1,079 were not exposed to LDA (the control group). The primary outcome was the rate of fetal congenital anomalies, and was compared between the LDA group and the control group. We also conducted logistic regression to examine the potential risk factors of congenital abnormalities.

Results
The average daily dose of LDA taken was 67.6 mg. The rate of congenital anomalies was comparable between the two groups, suggesting low teratogenicity of LDA application during pregnancy (3.3% vs. 2.8%; P = 0.421). The duration of LDA exposure and the time of LDA exposure showed no association with congenital anomalies. A previous history of fetal congenital anomalies was associated with an increased risk of the recurrence of congenital anomalies in the siblings (adjusted OR = 3.00, 95% CI: 1.00–8.60; P = 0.041).

Conclusion
Exposure to LDA during pregnancy did not increase the risk of congenital anomalies in the fetus, suggesting that it was safe to apply LDA during pregnancy. A history of previous fetal abnormalities was found to be an independent risk factor of congenital anomalies. Our study suggests that LDA can be safely applied during pregnancy without increasing risks of congenital anomalies.