bluuebunny/crossref_metadata_2025_split huggingface dataset:
The German version of the Nottingham Clavicle Score is a reliable and valid patient-reported outcome measure to evaluate patients with clavicle and acromioclavicular pathologies
Authors: Scheidt Sebastian , Zapatka Jakob , Freytag Richard Julius , Pohlentz Malin Sarah , Paci Matteo , Kabir Koroush , Burger Christof , Cucchi Davide 
Published: August 2022

Abstract
Purpose
The Nottingham Clavicle Score (NCS) is a patient-reported outcome measure developed to evaluate treatment results of clavicle, acromioclavicular and sternoclavicular joint pathologies. Valid, reliable and user-friendly translations of outcome measure instruments are needed to allow comparisons of international results. The aim of this cross-sectional study was to translate and adapt the NCS into German and evaluate the psychometric properties of the German version.

Methods
The translation and cross-cultural adaptation of the NCS were completed using a ‘translation–back translation” method and the final version was administered to 105 German-speaking patients. The psychometric properties of this version (NCS-G) were evaluated in terms of feasibility, reliability, validity and sensitivity to change.

Results
No major differences occurred between the NCS translations into German and back into English, and no content- or linguistic-related difficulties were reported. The Cronbach’s alpha for the NCS-G was 0.885, showing optimal internal consistency. The Intraclass Correlation Coefficient for test–retest reliability was 0.907 (95% CI 0.844–0.945), with a standard error of measurement of 5.59 points and a minimal detectable change of 15.50 points. The NCS-G showed moderate to strong correlation with all other investigated scales (Spearman correlation coefficient: qDASH: ρ =  – 0.751; OSS: ρ = 0.728; Imatani Score: ρ = 0.646; CMS: ρ = 0.621; VAS: ρ =  – 0.709). Good sensitivity to change was confirmed by an effect size of 1.17 (95% CI 0.89–1.47) and a standardized response mean of 1.23 (95% CI 0.98–1.45).

Conclusions
This study demonstrated that NCS-G is reliable, valid, reproducible and well accepted by patients, showing analogous psychometric properties to the original English version.

Level of evidence
Level III.
Calibrating error variance and scaling global covariance function of geoid gradients for optimal determinations of gravity anomaly and gravity gradient from altimetry
Authors: Yu Daocheng , Hwang Cheinway 
Published: August 2022

AbstractWith the advancements of satellite altimeter technology and data volume, the accuracy and spatial resolution of altimeter-derived marine gravity fields have been steadily improved. Ideally, a best marine gravity field from multi-altimeter missions is one that combines all data by optimally calibrating their relative weights. To this end, we use the minimum norm quadratic unbiased estimator theory to calibrate error variances of geoid gradients (GGs) from the Cryosat-2 mission and the Jason-1/2 geodetic missions and then use a scaling factor to modify the global covariance functions into local covariance functions. The calibrated error variances and the scaling factors are used in the least-squares collocation to estimate the gridded north and east components of GGs, which are used to compute gravity anomaly and vertical gravity gradient (VGG) by the methods of inverse Vening-Meinesz (IVM) and numerical differentiations. The assessment of the altimeter-derived gravity anomalies in the northern part of the South China Sea using the shipborne gravity data shows an average gravity accuracy improvement of 9.5% by calibrated and scaled covariances of GGs compared to the initial variances. The method for VGG computations is confirmed by examining the extinct ridges in the Gulf of Mexico.
Dynamics of diffusion on monoplex and multiplex networks: a message-passing approach
Authors: Kobayashi Teruyoshi , Onaga Tomokatsu 
Published: August 2022

AbstractNew ideas and technologies adopted by a small number of individuals occasionally spread globally through a complex web of social ties. Here, we present a simple and general approximation method, namely, a message-passing approach, that allows us to describe the diffusion processes on (sparse) random networks in an almost exact manner. We consider two classes of binary-action games where the best pure strategies for individual players are characterized as variants of the threshold rule. We verify that the dynamics of diffusion observed on synthetic networks are accurately replicated by the message-passing equation, whose fixed point corresponds to a Nash equilibrium, while the conventional mean-field method tends to overestimate the size and frequency of diffusion. Generalized cascade conditions under which a global diffusion can occur are also provided. We extend the framework to analyze multiplex networks in which social interactions take place in multiple layers.
A blow-up result for a Nakao-type weakly coupled system with nonlinearities of derivative-type
Authors: Palmieri Alessandro , Takamura Hiroyuki 
Published: August 2022

AbstractIn this paper, we consider a weakly coupled system of a wave and damped Klein–Gordon equation with nonlinearities of derivative type. We prove a blow-up result for the Cauchy problem associated with this system for nonnegative and compactly supported data by means of an iteration argument.
A type of oscillatory integral operator and its applications
Authors: Gao Chuanwei , Li Jingyue , Wang Liang 
Published: August 2022

AbstractIn this paper, we consider $$L^p$$

L
p

- estimate for a class of oscillatory integral operators satisfying the Carleson–Sjölin conditions with further convex and straight assumptions. As applications, the multiplier problem related to a general class of hypersurfaces with nonvanishing Gaussian curvature, local smoothing estimates for the fractional Schrödinger equation and the sharp resolvent estimates outside of the uniform boundedness range are discussed.
Trabecular metal monoblock versus modular tibial trays in total knee arthroplasty: meta-analysis of randomized control trials
Authors: Abulhail Safa , Hameed Shamsi , Abousamhadaneh Maamoun , Al Haneedi Ghalib , Al Ateeq Aldosari Mohamed 
Published: August 2022

Abstract
Purpose
Total knee arthroplasty is one of the significantly evolving procedures with different knee designs available in the market. The continued development of these prosthesis resulted in improvement of the implant survivorship and patient satisfaction. This study is an RCT-based meta-analysis aimed to compare two designs of total knee replacement: the conventional modular and the monoblock trabecular metal tibial trays.

Methods
This meta-analysis was performed by a literature review according to the PRISMA guidelines. A detailed search of the English literature was done using the PubMed, Medline, CINAHL, Cochrane, Embase, and Google Scholar databases. Only randomized control trials were included in the analysis after ensuring homogeneity. RevMan V.5.0.18.33 (The Cochrane Collaboration, Copenhagen, Denmark) was used to perform the meta-analysis. Extracted outcome measures were Knee Society score, Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) score, survivorship, complication rate, and radiostereographic analysis.

Results
Seven randomized control trials with 635 patients were eligible for our analysis after they met our inclusion criteria. Three hundred twelve patients received monoblock tibias, and the other 323 patients received modular tibial trays during their total knee arthroplasty surgeries. There were statistically significant superiority of the modular knees in the functional Knee Society and WOMAC scores at five years (P = 0.003 and 0.05, respectively). The modular design was also more stable on RSA at two years (P < 0.0001).

Conclusion
Modular and monoblock tibial trays are comparable knee designs with comparable survivorship and complication rates. However, the modular knees had better mid-term functional outcome and are more stable on radiostereographic analysis.
Moisture source identification for precipitation associated with tropical cyclone development over the Indian Ocean: a Lagrangian approach
Authors: Pérez-Alarcón Albenis , Fernández-Alvarez José C. , Sorí Rogert , Nieto Raquel , Gimeno Luis 
Published: August 2022

AbstractIn this study, we investigated the moisture sources for precipitation through a Lagrangian approach during the genesis, intensification, and dissipation phases of all tropical cyclones (TCs) that occurred over the two hemispheric sub-basins of the Indian Ocean (IO) from 1980 to 2018. In the North IO (NIO), TCs formed and reached their maximum intensity on both sides of the Indian Peninsula, to the east in the Bay of Bengal (BoB), and to the west in the Arabian Sea (AS). The oceanic areas where TCs occurred were their main moisture sources for precipitation associated with TCs. Additionally, for TCs over the BoB, continental sources from the Ganges River basin and the South China Sea also played a notable role; for TCs over the AS, the Somali Low-Level jet (along the African coast in a northerly direction) also acted as an essential moisture transport. In the South IO (SIO), the western, central, and eastern basins were identified as the preferred areas for the genesis and development of TCs. During TC activity, the central IO and the Wharton and Perth basins mostly supplied atmospheric moisture. The Mascarene High circulation was the main moisture transport mechanism for the precipitation of TCs formed in the SIO basin. In both basins, during their intensification process, TCs gained more moisture (even more intensely when reaching the hurricane category) than during the genesis or dissipation stages. Additionally, the modulation during monsoonal seasons of the moisture contribution to the TCs was more noticeable over the NIO basin than for the SIO. Overall, the moisture uptake for precipitation from the sources for TCs occurred slightly faster in the NIO basin than in the SIO basin.
Acid sphingomyelinase deactivation post-ischemia promotes brain angiogenesis and remodeling by small extracellular vesicles
Authors: Mohamud Yusuf Ayan , Hagemann Nina , Zhang Xiaoni , Zafar Maria , Hussner Tanja , Bromkamp Carolin , Martiny Carlotta , Tertel Tobias , Börger Verena , Schumacher Fabian , Solari Fiorella A. , Hasenberg Mike , Kleinschnitz Christoph , Doeppner Thorsten R. , Kleuser Burkhard , Sickmann Albert , Gunzer Matthias , Giebel Bernd , Kolesnick Richard , Gulbins Erich , Hermann Dirk M. 
Published: August 2022

AbstractAntidepressants have been reported to enhance stroke recovery independent of the presence of depressive symptoms. They have recently been proposed to exert their mood-stabilizing actions by inhibition of acid sphingomyelinase (ASM), which catalyzes the hydrolysis of sphingomyelin to ceramide. Their restorative action post-ischemia/reperfusion (I/R) still had to be defined. Mice subjected to middle cerebral artery occlusion or cerebral microvascular endothelial cells exposed to oxygen–glucose deprivation were treated with vehicle or with the chemically and pharmacologically distinct antidepressants amitriptyline, fluoxetine or desipramine. Brain ASM activity significantly increased post-I/R, in line with elevated ceramide levels in microvessels. ASM inhibition by amitriptyline reduced ceramide levels, and increased microvascular length and branching point density in wildtype, but not sphingomyelinase phosphodiesterase-1 ([Smpd1]−/−) (i.e., ASM-deficient) mice, as assessed by 3D light sheet microscopy. In cell culture, amitriptyline, fluoxetine, and desipramine increased endothelial tube formation, migration, VEGFR2 abundance and VEGF release. This effect was abolished by Smpd1 knockdown. Mechanistically, the promotion of angiogenesis by ASM inhibitors was mediated by small extracellular vesicles (sEVs) released from endothelial cells, which exhibited enhanced uptake in target cells. Proteomic analysis of sEVs revealed that ASM deactivation differentially regulated proteins implicated in protein export, focal adhesion, and extracellular matrix interaction. In vivo, the increased angiogenesis was accompanied by a profound brain remodeling response with increased blood–brain barrier integrity, reduced leukocyte infiltrates and increased neuronal survival. Antidepressive drugs potently boost angiogenesis in an ASM-dependent way. The release of sEVs by ASM inhibitors disclosed an elegant target, via which brain remodeling post-I/R can be amplified.
Nociceptive pain in adult patients with 5q-spinal muscular atrophy type 3: a cross-sectional clinical study
Authors: Sagerer Elena , Wirner Corinna , Schoser Benedikt , Wenninger Stephan 
Published: August 2022

Abstract
Background
Spinal muscular atrophy (SMA) is an autosomal recessive neuromuscular disorder caused by mutations in the SMN gene, leading to progressive muscular weakness, atrophy and so far neglected musculoskeletal pain. This study is the first to characterize nociceptive pain in patients living with SMA type 3 by assessing whether muscle pain is associated with alterations in muscle strength, function, stiffness, frequency, decrement, relaxation, or creep.

Methods
We performed a cross-sectional pilot study on 20 SMA3 patients. We evaluated motor function and muscle strength (dynamometry, quick motor function test and 6-min-walk test), nociceptive pain (pressure algometer evaluating muscular pressure pain threshold (PPT)) and non-invasive measurement of muscle stiffness, frequency, decrement, relaxation, or creep (myotonometry with the MyotonPro®). For statistical analysis, we used t tests, Mann–Whitney U tests and linear regression.

Results
Significantly more women than men reported musculoskeletal pain (p = 0.003). A lower score in dynamometry was associated with lower scores in PPT in all extremities reflecting a higher sensitivity of these muscles to pressure. We did not find significant correlations between the PPT values and the MyotonPro values in the corresponding muscles. Assessments of PPT before and after the 6-min walk test did not show clinical meaningful changes. Besides nociceptive pain, fatigue was prevalent in 50% and pain in 55% of the patients.

Conclusions
Muscle pain in SMA3 is associated with muscular weakness in the arms and legs, but not with changes in muscular stiffness, frequency, decrement, relaxation, or creep. This shows that muscle pain in SMA3 is mainly caused by changes in the dysbalanced musculoskeletal system due to muscle weakness.
Multiscale fluorescence imaging of living samples
Authors: Wu Yicong , Shroff Hari 
Published: August 2022

AbstractFluorescence microscopy is a highly effective tool for interrogating biological structure and function, particularly when imaging across multiple spatiotemporal scales. Here we survey recent innovations and applications in the relatively understudied area of multiscale fluorescence imaging of living samples. We discuss fundamental challenges in live multiscale imaging and describe successful examples that highlight the power of this approach. We attempt to synthesize general strategies from these test cases, aiming to help accelerate progress in this exciting area.
Viruses, parkinsonism and Parkinson’s disease: the past, present and future
Authors: Leta Valentina , Urso Daniele , Batzu Lucia , Lau Yue Hui , Mathew Donna , Boura Iro , Raeder Vanessa , Falup-Pecurariu Cristian , van Wamelen Daniel , Ray Chaudhuri K. 
Published: August 2022

AbstractParkinsonism secondary to viral infections is not an uncommon occurrence and has been brought under the spotlight with the spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. A variety of viruses have been described with a potential of inducing or contributing to the occurrence of parkinsonism and Parkinson’s disease (PD), although the relationship between the two remains a matter of debate originating with the description of encephalitis lethargica in the aftermath of the Spanish flu in 1918. While some viral infections have been linked to an increased risk for the development of PD, others seem to have a causal link with the occurrence of parkinsonism. Here, we review the currently available evidence on viral-induced parkinsonism with a focus on potential pathophysiological mechanisms and clinical features. We also review the evidence on viral infections as a risk factor for developing PD and the link between SARS-CoV-2 and parkinsonism, which might have important implications for future research and treatments.
Herausforderung Transitionspsychiatrie im Rahmen der Erwachsenenpsychiatrie
Authors: Höflich Anna , Schrank Beate , Aigner Martin 
Published: August 2022

ZusammenfassungDie Transitionspsychiatrie ist ein relativ neues Feld innerhalb der Psychiatrie, das sich auf Menschen zwischen dem 14. und 25. Lebensjahr fokussiert. Sie versteht sich als Schnittstelle zwischen der Kinder- und Jugendpsychiatrie und der Erwachsenenpsychiatrie, als „Missing Link“ im Übergang zum Erwachsenenleben. In der aktuellen Versorgungslandschaft wird die Gruppe der 14- bis 18-Jährigen von der Kinder- und Jugendpsychiatrie behandelt, ab dem 18. Lebensjahr erfolgt die Behandlung in Abteilungen für Psychiatrie. Dieser abrupte Übergang wird der psychischen Entwicklung der Patient*innen nicht immer gerecht. Es ist also zunehmend wichtig, den Entwicklungsgedanken in dieser Transitionszeit in den Bereich der Erwachsenenpsychiatrie auszudehnen und neue Versorgungsstrukturen für diese Gruppe von Patient*innen zu ermöglichen. Am Universitätsklinikum Tulln wurde dazu ein interdisziplinäres Forschungszentrum für Transitionspsychiatrie eingerichtet, um adäquate Strukturen zur Versorgung dieser Altersgruppe zu entwickeln. In einer ersten Qualitätssicherung wurden die Problembereiche von 30 Patient*innen (19 Frauen) der Zielgruppe analysiert, welche routinemäßig an einer psychiatrischen Abteilung behandelt wurden. Wichtig ist es, für diese Gruppe eine gute Synchronisation von Therapie und laufender Entwicklung zu erreichen. Entsprechende Strukturen nach internationalem Vorbild sollen zukünftig eine umfassende und an die zahlreichen Entwicklungsaufgaben angepasste Versorgung dieser Gruppe ermöglichen.
Impact of the COVID-19 pandemic on accredited conformity assessment bodies: insights from a multinational study
Authors: Koch Claudia , Asna Ashari Parsa , Mirtsch Mona , Blind Knut , Castka Pavel 
Published: August 2022

AbstractThe COVID-19 pandemic posed new and manifold challenges to organizations and their operations worldwide. Conformity assessment bodies (CABs), such as testing or medical laboratories, certification, and inspection bodies, were also affected by the associated disruptions. Their role in this crisis is highly relevant, as CABs are essential pillars of the quality infrastructure: their activities ensure that products and services meet requirements as defined in standards and regulations, thereby contributing to their safety and reliability. The question arises of how CABs and their operations were affected by the pandemic and how they responded. To this end, we present the results of an international survey of 986 CABs of all types in Germany, the UK, Italy, and New Zealand. Overall, CABs reported, on average, a reduction in demand for their services during the pandemic, facing restrictions in all countries. In addition, the pandemic had an overall negative impact on the CABs’ investment and innovation activities. However, investments in digital infrastructure were increased as a countermeasure, with CABs reporting a higher need for digitalization. The paper highlights and discusses results from in-depth analyses relevant to policymakers and industry alike.
Identifying, reducing, and communicating uncertainty in community science: a focus on alien species
Authors: Probert Anna F. , Wegmann Daniel , Volery Lara , Adriaens Tim , Bakiu Rigers , Bertolino Sandro , Essl Franz , Gervasini Eugenio , Groom Quentin , Latombe Guillaume , Marisavljevic Dragana , Mumford John , Pergl Jan , Preda Cristina , Roy Helen E. , Scalera Riccardo , Teixeira Heliana , Tricarico Elena , Vanderhoeven Sonia , Bacher Sven 
Published: August 2022

AbstractCommunity science (also often referred to as citizen science) provides a unique opportunity to address questions beyond the scope of other research methods whilst simultaneously engaging communities in the scientific process. This leads to broad educational benefits, empowers people, and can increase public awareness of societally relevant issues such as the biodiversity crisis. As such, community science has become a favourable framework for researching alien species where data on the presence, absence, abundance, phenology, and impact of species is important in informing management decisions. However, uncertainties arising at different stages can limit the interpretation of data and lead to projects failing to achieve their intended outcomes. Focusing on alien species centered community science projects, we identified key research questions and the relevant uncertainties that arise during the process of developing the study design, for example, when collecting the data and during the statistical analyses. Additionally, we assessed uncertainties from a linguistic perspective, and how the communication stages among project coordinators, participants and other stakeholders can alter the way in which information may be interpreted. We discuss existing methods for reducing uncertainty and suggest further solutions to improve data reliability. Further, we make suggestions to reduce the uncertainties that emerge at each project step and provide guidance and recommendations that can be readily applied in practice. Reducing uncertainties is essential and necessary to strengthen the scientific and community outcomes of community science, which is of particular importance to ensure the success of projects aimed at detecting novel alien species and monitoring their dynamics across space and time.
Use of Predictive Analytics within Learning Analytics Dashboards: A Review of Case Studies
Authors: Ramaswami Gomathy , Susnjak Teo , Mathrani Anuradha , Umer Rahila 
Published: August 2022

AbstractLearning analytics dashboards (LADs) provide educators and students with a comprehensive snapshot of the learning domain. Visualizations showcasing student learning behavioral patterns can help students gain greater self-awareness of their learning progression, and at the same time assist educators in identifying those students who may be facing learning difficulties. While LADs have gained popularity, existing LADs are still far behind when it comes to employing predictive analytics into their designs. Our systematic literature review has revealed limitations in the utilization of predictive analytics tools among existing LADs. We find that studies leveraging predictive analytics only go as far as identifying the at-risk students and do not employ model interpretation or explainability capabilities. This limits the ability of LADs to offer data-driven prescriptive advice to students that can offer them guidance on appropriate learning adjustments. Further, published studies have mostly described LADs that are still at prototype stages; hence, robust evaluations of how LADs affect student outcomes have not yet been conducted. The evaluations until now are limited to LAD functionalities and usability rather than their effectiveness as a pedagogical treatment. We conclude by making recommendations for the design of advanced dashboards that more fully take advantage of machine learning technologies, while using suitable visualizations to project only relevant information. Finally, we stress the importance of developing dashboards that are ultimately evaluated for their effectiveness.