bluuebunny/crossref_metadata_2025_split huggingface dataset:
External validation of the NeuroImaging Radiological Interpretation System and Helsinki computed tomography score for mortality prediction in patients with traumatic brain injury treated in the intensive care unit: a Finnish intensive care consortium study
Authors: Vehviläinen Juho , Skrifvars Markus , Reinikainen Matti , Bendel Stepani , Laitio Ruut , Hoppu Sanna , Ala-Kokko Tero , Siironen Jari , Raj Rahul 
Published: September 2022

Abstract
Background
Admission computed tomography (CT) scoring systems can be used to objectively quantify the severity of traumatic brain injury (TBI) and aid in outcome prediction. We aimed to externally validate the NeuroImaging Radiological Interpretation System (NIRIS) and the Helsinki CT score. In addition, we compared the prognostic performance of the NIRIS and the Helsinki CT score to the Marshall CT classification and to a clinical model.

Methods
We conducted a retrospective multicenter observational study using the Finnish Intensive Care Consortium database. We included adult TBI patients admitted in four university hospital ICUs during 2003–2013. We analyzed the CT scans using the NIRIS and the Helsinki CT score and compared the results to 6-month mortality as the primary outcome. In addition, we created a clinical model (age, Glasgow Coma Scale score, Simplified Acute Physiology Score II, presence of severe comorbidity) and combined clinical and CT models to see the added predictive impact of radiological data to conventional clinical information. We measured model performance using area under curve (AUC), Nagelkerke’s R2 statistics, and the integrated discrimination improvement (IDI).

Results
A total of 3031 patients were included in the analysis. The 6-month mortality was 710 patients (23.4%). Of the CT models, the Helsinki CT displayed best discrimination (AUC 0.73 vs. 0.70 for NIRIS) and explanatory variation (Nagelkerke’s R2 0.20 vs. 0.15). The clinical model displayed an AUC of 0.86 (95% CI 0.84–0.87). All CT models increased the AUC of the clinical model by + 0.01 to 0.87 (95% CI 0.85–0.88) and the IDI by 0.01–0.03.

Conclusion
In patients with TBI treated in the ICU, the Helsinki CT score outperformed the NIRIS for 6-month mortality prediction. In isolation, CT models offered only moderate accuracy for outcome prediction and clinical variables outweighing the CT-based predictors in terms of predictive performance.
On 2+1-dimensional fibre-reinforced fluid motions: a magnetohydrodynamics nexus
Authors: Demskoi Dmitry K. , Rogers Colin , Schief Wolfgang K. 
Published: September 2022

AbstractAn intrinsic geometric decomposition is applied to provide via a canonical third-order nonlinear equation a connection between 2+1-dimensional fibre-reinforced motions of a fluid and a magnetohydrodynamic system. A Lagrange-type parametrisation is introduced, whereby both geometric and algebraic properties of certain non-steady magnetohydrodynamic motions may be established.
A prospective, randomized assessment of a novel, local antibiotic releasing platform for the prevention of superficial and deep surgical site infections
Authors: Zmora O. , Stark Y. , Belotserkovsky O. , Reichert M. , Kozloski G. A. , Wasserberg N. , Tulchinsky H. , Segev L. , Senagore A. J. , Emanuel N. 
Published: September 2022

Abstract
Background
Despite significant advances in infection control guidelines and practices, surgical site infections (SSIs) remain a substantial cause of morbidity, prolonged hospitalization, and mortality among patients having both elective and emergent surgeries. D-PLEX100 is a novel, antibiotic-eluting polymer–lipid matrix that supplies a high, local concentration of doxycycline for the prevention of superficial and deep SSIs. The aim of our study was to evaluate the safety and efficacy of D-PLEX in addition to standard of care (SOC) in preventing superficial and deep surgical site infections for patients undergoing elective colorectal surgery.

Methods
From October 10, 2018 to October 6, 2019, as part of a Phase 2 clinical trial, we randomly assigned 202 patients who had scheduled elective colorectal surgery to receive either standard of care SSI prophylaxis or D-PLEX100 in addition to standard of care. The primary objective was to assess the efficacy of D-PLEX100 in superficial and deep SSI reduction, as measured by the incidence of SSIs within 30 days, as adjudicated by both an individual assessor and a three-person endpoint adjudication committee, all of whom were blinded to study-group assignments. Safety was assessed by the stratification and incidence of treatment-emergent adverse events.

Results
One hundred and seventy-nine patients were evaluated in the per protocol population, 88 in the intervention arm [51 males, 37 females, median age (64.0 range: 19–92) years] and 91 in the control arm [57 males, 34 females, median age 64.5 (range: 21–88) years]. The SSI rate within 30 day post-index surgery revealed a 64% relative risk reduction in SSI rate in the D-PLEX100 plus standard of care (SOC) group [n = 7/88 (8%)] vs SOC alone [n = 20/91 (22%)]; p = 0.0115. There was no significant difference in treatment-emergent adverse events.

Conclusions
D-PLEX100 application leads to a statistically significant reduction in superficial and deep surgical site infections in this colorectal clinical model without any associated increase in adverse events.
Computer Simulation of the Electrical Stimulation of the Human Vestibular System: Effects of the Reactive Component of Impedance on Voltage Waveform and Nerve Selectivity
Authors: D’Alessandro Simone , Handler Michael , Saba Rami , Garnham Carolyn , Baumgarten Daniel 
Published: September 2022

AbstractThe vestibular system is responsible for our sense of balance and spatial orientation. Recent studies have shown the possibility of partially restoring the function of this system using vestibular implants. Electrical modeling is a valuable tool in assisting the development of these implants by analyzing stimulation effects. However, previous modeling approaches of the vestibular system assumed quasi-static conditions. In this work, an extended modeling approach is presented that considers the reactive component of impedance and the electrode-tissue interface and their effects are investigated in a 3D human vestibular computer model. The Fourier finite element method was employed considering the frequency-dependent electrical properties of the different tissues. The electrode-tissue interface was integrated by an instrumental electrode model. A neuron model of myelinated fibers was employed to predict the nerve responses to the electrical stimulus. Morphological changes of the predicted voltage waveforms considering the dielectric tissue properties were found compared to quasi-static simulations, particularly during monopolar electrode configuration. Introducing the polarization capacitance and the scar tissue around the electrode in combination with a power limitation leads to a considerable current reduction applied through the active electrode and, consequently, to reduced voltage amplitudes of the stimulus waveforms. The reactive component of impedance resulted in better selectivity for the excitation of target nerves compared to the quasi-static simulation at the expense of slightly increased stimulus current amplitudes. We conclude that tissue permittivity and effects of the electrode-tissue interface should be considered to improve the accuracy of the simulations.
Semilinear Li and Yau inequalities
Authors: Castorina Daniele , Catino Giovanni , Mantegazza Carlo 
Published: September 2022

AbstractWe derive an adaptation of Li and Yau estimates for positive solutions of semilinear heat equations on Riemannian manifolds with nonnegative Ricci tensor. We then apply these estimates to obtain a Harnack inequality and to discuss monotonicity, convexity, decay estimates and triviality of ancient and eternal solutions.
Seasonal Changes in Boundary-Layer Flow Over a Forested Escarpment Measured by an Uncrewed Aircraft System
Authors: zum Berge Kjell , Gaiser Annika , Knaus Hermann , Platis Andreas , Bange Jens 
Published: September 2022

AbstractThe uncrewed airborne measurement platform MASC-3 (Multi-Purpose Airborne Sensor Carrier) is used to measure the influence of a forested escarpment with differing leaf area indices (LAI) onto the wind field. Data from flight legs between 30 and 200 m above ground with uphill (westerly) wind during summer (July–September) and winter (October–March) seasons between 2018 and 2021 are analyzed. Compared with a low value of LAI, it is found that the mean wind speed acceleration is stronger for a high values of LAI, and the turbulence is enhanced in the lee of the trees in the lowest 20–60 m above ground. During summer with a high LAI, the inclination angle is more clearly defined into an upward motion above the slope and downward motion above the plateau. The results of the airborne dataset fits well into the theoretical and analytical models established in the 1970s and 1980s.
Ecosystem services provided by freshwater and marine diatoms
Authors: B-Béres Viktória , Stenger-Kovács Csilla , Buczkó Krisztina , Padisák Judit , Selmeczy Géza B. , Lengyel Edina , Tapolczai Kálmán 
Published: September 2022

AbstractDiatoms, a unique group of algae colonising a wide range of aquatic habitats and contributing to human well-being in many ways. We list and summarise these services using the classification of the Millennium Ecosystem Assessment (MEA), i.e. supporting, regulating, provisioning and cultural services. The most relevant supporting services are photosynthesis and primary production, as well as sediment formation. They also play a key role in nutrient cycling and habitat provisioning and serve as food for many organisms. Regulating services as oxygen production, climate control or sediment stabilisation are difficult to discuss without diatoms. Many provisioning services, directly used by humans, can be obtained from diatoms. These are tangible products such as medicines and immunostimulants but direct technologies such as wastewater treatment, micro- and nanotechnologies were also developed using diatoms. Studying of the past, present, and future linked to diatoms as a tool for palaeolimnology, ecological status assessment of waters and climate modelling is essential. Finally, the impressive morphology and ornaments of diatom frustules make them one of the most spectacular microorganisms, inspiring artists or providing a number of educational opportunities. Therefore, protecting aquatic habitats they inhabit is not simply a nature conservation issue but the key for human well-being in the future.
Influence of Giant Reed Fibers on Mechanical, Thermal, and Disintegration Behavior of Rotomolded PLA and PE Composites
Authors: Suárez Luis , Ortega Zaida , Romero Francisco , Paz Rubén , Marrero María D. 
Published: September 2022

AbstractThis paper assesses the modifications in the properties of rotomolded polyethylene (PE) and polylactic acid (PLA) composites obtained with 5 and 10% giant reed fibers, mainly focusing on the alterations due to a bio-disintegration process. Thermal properties (melting temperature and crystallinity degree), morphology (via optical and scanning electron microscopy), and chemical changes (by Fourier Transformed Infrared spectroscopy) were studied. Composites with untreated and NaOH-treated fibers were obtained, finding that this treatment does not improve the mechanical performance of composites due to increased porosity. The introduction of natural fibers into a PE matrix does not significantly modify the thermal and bio-disintegration properties of the rotomolded material. Regarding mechanical properties, PE-composites show increased tensile modulus and reduced impact and tensile strength than the matrix. On the other hand, PLA composites show lower impact and flexural strength than neat PLA, remaining the rest of the mechanical properties unchanged regardless of the fibers' addition. The incorporation of Arundo fibers modifies to a great extent the thermal and degradation behavior of the PLA matrix.
Laser ablation inductively coupled plasma mass spectrometry analysis of isotopically heterogeneous uranium materials
Authors: Varga Zsolt , Wallenius Maria , Nicholl Adrian , Mayer Klaus 
Published: September 2022

AbstractA reliable and accurate laser ablation multi-collector inductively coupled plasma mass spectrometry (LA-MC-ICP-MS) method was developed for analysis of inhomogeneous samples containing uranium particles or aggregates of various enrichments. For the method development, a mixed solid standard was prepared using 1% and 3% 235U enriched certified reference materials. After screening and localization of the particles of interest, the U isotopic composition was analysed for a 5-µm sample spot determining accurately and precisely the various constituents. Besides the LA-MC-ICP-MS, the standard was also measured by large-geometry secondary ion mass spectrometry (LG-SIMS) for additional verification.
A methodology for the analysis of continuous time-series of automatic inclinometers for slow-moving landslides monitoring in Piemonte region, northern Italy
Authors: Bordoni Massimiliano , Vivaldi Valerio , Bonì Roberta , Spanò Simone , Tararbra Mauro , Lanteri Luca , Parnigoni Matteo , Grossi Alessandra , Figini Silvia , Meisina Claudia 
Published: September 2022

AbstractIn-place automatic inclinometers are typical devices used to monitor displacements of extremely slow to slow-moving landslides. The significance of these measurements requires methodologies able to distinguish real measures from anomalous ones, to quantify significant moments of acceleration in deformation trends and to determine the main factors that influence the kinematic behavior measured by an automatic inclinometer. This work aimed at developing a novel method, which allows to cover all the steps of analysis of data acquired by automatic inclinometers. The methodology is composed by five steps: (I) evaluation of the reliability of the instruments; (II) identification and elimination of anomalous measures from displacement time-series; (III) recognition of significant moments of acceleration in the rate of displacement, through thresholds based on the mean rate of displacement and on the cumulated amount of the deformation; (IV) clustering of the events of significant acceleration, to characterize different typologies of events according to different landslides kinematic behaviors; (V) identification of the main meteorological and groundwater parameters influencing the deformation pattern measured by an automatic inclinometer. The methodology was developed and tested using displacement time-series of 89 automatic inclinometers, belonging to the regional monitoring network of Piemonte region (northern Italy), managed by Arpa Piemonte. Two representative inclinometric time-series were selected to validate all the steps of the methodology for different types of monitored slow-moving landslides. The developed method is reliable in the estimation of anomalous measures and in the identification of significant accelerations, helping in the comprehension of the response of displacement trends during activity phases. Moreover, it is able to identify the factors which influence more the deformation pattern measured in correspondence of an automatic inclinometer.
Epoxidation of methyl oleate over various amorphous Ti–SiO2 catalysts
Authors: Kim Kyunghoon , Venschott Moritz , Hoelderich Wolfgang F. 
Published: September 2022

Abstract
The epoxidation reaction of the vegetable oil derivative methyl oleate with tert-butyl hydroperoxide in the presence of amorphous Ti–SiO2 catalysts prepared by different methods using various silica sources was carried out. The reaction conditions were optimized. The relation between the properties of the catalysts such as specific surface area as well as titanium dispersion and the catalytic performance was in focus of the investigation. Based on the catalytic results in small batch reactors, the reaction was scaled up in a larger 4 L batch-reactor. Thereby similar conversions and selectivities were obtained in comparison with the small scale experiments.
Exploring temporal patterns in fish feeding ecology: Are ontogenetic dietary shifts stable over time?
Authors: Sánchez-Hernández Javier , Prati Sebastian , Henriksen Eirik Haugstvedt , Smalås Aslak , Knudsen Rune , Klemetsen Anders , Amundsen Per-Arne 
Published: September 2022

AbstractDisentangling the causes and consequences of ontogenetic niche shifts has been a pivotal challenge in ecology, aiming to enhance the understanding of biological processes that function at the individual, population, and community levels. Studies on ontogenetic dietary shifts have traditionally focused on short time scales, mostly including sampling covering just one or a few consecutive years, thus neglecting possible aspects of temporal variation and ecosystem stability that can only be revealed on long-term scales. We address ontogenetic dietary shifts of two fish predators in an intraguild system (Arctic charr and brown trout) using a long-term dataset spanning 20 consecutive years. Our study revealed distinct ontogenetic niche shifts of the two intraguild predators and demonstrated that these patterns were stable over time, suggesting large stability in prey acquisition and resource partitioning despite changes in their abundances and relative species composition. Some interannual variation was observed, but this was primarily due to sampling bias from low observation numbers for some ontogenetic stages, reflecting a common methodical challenge for ontogenetic niche shift studies. The persistent patterns in the trophic ontogeny of intraguild predators likely facilitate population and community stability by reducing inter- and/or intraspecific competition, thereby having important consequences for ecosystem functioning and resilience. Our study provides a strong rationale for performing ontogenetic niche shift studies over several consecutive years, enabling important insights into temporal variation, enhancement of observation numbers by merging data from multiple years, and the facilitation of a less intrusive sampling scheme for more vulnerable populations.
Impact of Physical Heterogeneity and Transport Conditions on Effective Reaction Rates in Dissolution
Authors: Oliveira Rodolfo , Blunt Martin J. , Bijeljic Branko 
Published: September 2022

AbstractA continuous-time random walk (CTRW) reactive transport model is used to study the impact of physical heterogeneity on the effective reaction rates in porous media in a sample of length 15 cm over timescales up to 10$$^8$$

8

s (3 years). The model has previously been validated using nuclear magnetic resonance (NMR) measurements during dissolution of a limestone. The model assumes first-order reaction. We construct three domains with increasing physical heterogeneity and study dissolution at four Péclet numbers, Pe = 0.0542, 0.542, 5.42 and 54.2. We characterize signatures of physical heterogeneity in the three porous media using velocity distributions and show how these imprint on the signatures of particle displacement, namely particle propagator distributions. In addition, we demonstrate the ability of our CTRW model to capture the impact of physical heterogeneity on the longitudinal dispersion coefficient over several orders of magnitude in space and time. Reactive transport simulations show that the effective reaction rates depend on (i) initial physical heterogeneity and (ii) transport conditions. For all heterogeneities and Pe, the late-time reaction rate exhibits a time dependence $$t^{-a}$$

t

-
a

with $$a \ne 0.5$$

a
≠
0.5

that indicates the persistence of incomplete mixing. We show that the higher the initial heterogeneity, the lower the late-time reaction rate. A decrease in Pe promotes mixing by diffusion over advection, resulting in higher reaction rates. The post-dissolution propagators indicate an increase in the degree of non-Fickian transport. Overall, we establish a framework to demonstrate and quantify the impact of physical heterogeneity on transport and effective reaction rates in porous media.
Rebalancing with transaction costs: theory, simulations, and actual data
Authors: El Bernoussi Rim , Rockinger Michael 
Published: September 2022

AbstractIn the absence of transaction costs and the presence of independent returns, a buy-and-hold strategy theoretically generates higher expected returns than a fixed-weight strategy, where the portfolio weights are regularly readjusted/rebalanced to some initial level. This higher expected return comes with higher volatility. The resulting trade-off leads to different rankings of the Sharpe ratio depending on the statistical moments of the assets. We also focus on Maximum Drawdown. We theoretically discuss causes affecting the ranking of the Sharpe ratio, and we introduce an easy-to-implement methodology to deal with proportional transaction costs. Under transaction costs, the buy-and-hold strategy as the cheaper approach should be the winner. In various simulation experiments, we investigate the relevance of transaction costs on rebalancing strategies. Eventually, we consider several realistic portfolios with a risk-free asset, bonds, stock indices, commodities and real estate that allow us to demonstrate that in practice rebalancing has value.
On Processing Potato 2. Survey of Products, Processes and Operations in Manufacturing
Authors: Haverkort A. J. , Linnemann A. R. , Struik P. C. , Wiskerke J. S. C. 
Published: September 2022

AbstractIn supermarkets in the Netherlands, well over 150 potato products are displayed. They can be distinguished by heating characteristics (boiled or fried), appearance (e.g., intact tuber pieces or formed hash browns), dehydrated (e.g., snacks and flour) and storage temperature (e.g., ambient and frozen). Fancier products (frozen formed versus chilled blanched) require more processes and operations in factories and are more expensive; consumers appreciate them because they offer more convenience. Heatmapping and hierarchical clustering were carried out twice within the domain of classes of products and their attributes. In a theoretical triangulation, consumers give high scores to low prices and a wide range of products, tastes and sizes where processors give these attributes a low score. Processes in factories include dehydration, heating, cooling and transformation. Examples of the latter are modification of starch to increase the range of applications in the food industry, forming of mash and shreds to produce croquettes and hash browns and expansion to make snacks. Processes require operations such as washing, cutting, blanching and packing. In total, between the arrival of the tubers at the gate and leaving as packed products to outlets, 66 operations are distinguished. French fries undergo some 30 operations and to produce flakes, 8 suffice. Heatmapping and hierarchical clustering differentiate a group of physical operations (with attributes associated with heating and cooling that require much energy) and mechanical ones (related to separation, grading, sorting for instance and size reduction of which shredding is an example that require little energy). The wide range of operations in large factories, reducing the moisture content and longtime storage at low temperatures, distinguishes potato from wheat that has fewer operations while increasing the moisture content in relatively small bakeries and the product, bread, stored for about one day in ambient conditions.