bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Vestibular Ocular Reflex In Parkinsonian Mice
Authors: Raitman Irene , Cullen Kathleen E. 
Published: July 2022

Parkinson's disease (PD) is a progressive neurological disorder characterized by poor balance, slow movement, rigidity, and uncontrollable tremors of the hands. These symptoms result from the degeneration of dopamine-producing nerve cells in the brain, specifically in the substantia nigra and the locus coeruleus. Dopamine is a neurotransmitter that is released by the brain and stimulates motor neurons. When dopamine production is depleted, the motor system is unable to control movement and coordination and PD symptoms occur.
The goal of this experiment was to gain a better understanding of the effects of PD on the vestibular system. More specifically, the effect of the destruction of the dopamine producing cells on the vestibular ocular reflex (VOR) was investigated. The VOR is a gaze-stabilization reflex which maintains eye fixation on an object during head rotation. As the head turns, the eyes compensate by slowly turning in the opposite direction. As the eyes reach the limit of their turning range, they quickly reset by returning to their starting position. Together, the VOR (slow phase) and the resetting (quick phase) make up the vestibular nystagmus. The VOR produced during horizontal and vertical rotations by untreated mice was compared with the VOR produced by those mice that were injected with MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine), a drug known to destroy the dopamine producing neurons in humans, primates, and rodents. In addition, the relationship between peak eye velocity and amplitude of the quick phases was analyzed to see if the quick phase was altered in MPTP-treated mice.
The Difficulty In Computing Ancestral DNA Sequences: Using Computational Analysis To Reconstruct DNA Sequences
Authors: Li Zhentao , Blanchette Mathieu 
Published: July 2022

Intriguing work has been carried out in order to decipher the genetic codes of today’s existing species. However, little is known about the genetic makeup of species that existed long ago. Exciting possibilities have recently been raised in the field of computational analysis (1), proposing that reconstruction of ancestral DNA sequences can be performed if the DNA sequences of the existing species are known. Being able to perform such reconstructions would simplify the study of the evolution of these species, and uncover many mysteries regarding life that once existed on this planet.
In order to perform reconstructions of unknown ancestral DNA sequences, many different types of problems must be solved, all of which can be approached computationally. Examples of such problems include building a phylogenetic tree of the evolutionary line in question, determining a multiple alignment of the existing species being analyzed, or working out the actual identity of the nucleotides within the ancestral sequence. The problem presented in this paper considers the level of modification within the ancestral sequence.
Evolution of Algorithms to find Prime Numbers
Authors: Kaczorowski Maya 
Published: July 2022

Prime numbers, and the deterministic formulas used to find them, have garnered considerable attention from mathematicians, professionals and amateurs alike. A prime number is a positive integer, excluding 1, whose only divisors are 1 and itself. For example, 23 is a prime number as it can only be divided by 1 and 23. A number that is not prime is called a composite number.
While prime numbers under 100 are fairly abundant, they become less frequent and difficult to find in a systematic manner as the digits in the number increase since they do not appear to follow a predictable distribution. So why do researchers keep studying them? For over 150 years, mathematicians have attempted to uncover a deterministic formula to identify prime numbers. If such a formula existed, all numbers could be factored relatively quickly using computers. Paradoxically, much of electronic data today is encrypted by taking advantage of the fact that it is difficult and time consuming for a computer program to factor a large composite number. A formula to find all prime numbers would be a significant breakthrough in mathematics, but severely detrimental to data security.
A pragmatikai képesség atipikus fejlődése
Authors: Svindt Veronika 
Published: July 2022

Jelen tanulmány az atipikus pragmatikai fejlődés és az ebből fakadó pragmatikai zavarok okait és jellemző megjelenési formáit tekinti át. A pragmatikai képesség teszi lehetővé, hogy a mindenkori nyelvi tevékenységnek teret adó dinamikusan változó közegben, vagyis egy szociokulturális, környezeti és kognitív feltételrendszer által meghatározott mátrixban hatékonyan vegyünk részt a kommunikációban. Az anyanyelv-elsajátítás folyamatában a strukturális nyelvi képességek mellett a pragmatikai nyelvhasználat fejlődése is zajlik. Ez a fejlődés azonban mind ütemében, mint időtartamában jelentősen eltér a strukturális nyelvi képességek fejlődésétől: a pragmatikai képességek fejlődése a nyelvtani fejlődés előtt megindul, mégis jóval tovább tart.
A pragmatikai fejlődés minőségét jelentős mértékben befolyásolja a gyermek közvetlen környezete és szocioökonómiai státusza. Az ebben mért, tipikustól való elmaradás önmagában is vezethet a pragmatikai fejlődés késéséhez vagy korlátozottságához.
Az elmúlt évtizedek kutatásai bizonyos fejlődési zavarok genetikai és neuroanatómiai hátterének feltárása során meghatároztak olyan, a tipikus neurokognitív fejlődéstől eltérő mintázatokat, amelyek a szociális kommunikáció és a pragmatikai képesség területén tapasztalható elmaradáshoz vezethetnek. A genetikai és neuroanatómiai háttértől nem elválasztható a pragmatikai képesség működéséhez szükséges kognitív feltételek megismerése. Bár a rendelkezésre álló kutatások nem minden esetben jutottak azonos eredményre, bizonyos markáns evidenciák így is megállapíthatók. Eszerint a pragmatikai képesség erős korrelációt mutat a strukturális nyelvi képességek, a végrehajtó funkciók, valamint a tudatelméleti képesség működésével.
Az autizmus spektrum zavar (ASD), a figyelemhiányos/hiperaktivitás zavar (ADHD), a nyelvfejlődési zavar (NYZ) vagy az intellektuális képességzavarok esetében nagy valószínűséggel vagy éppen szükségszerűen számolni kell a pragmatikai képességek zavarával is. Emellett számon tartunk egy olyan fejlődési zavart is, amelynek vezető tünete és diagnosztikai kritériuma a szociális és társas kommunikáció területén mért jelentős nehézség: a felsorolt fejlődési zavarok mellett jelen tanulmányban szót ejtünk a társas pragmatikai kommunikációs zavarról (PKZ) is.
A tanulmány tehát áttekintést igyekszik nyújtani azokról a szocioökonómiai, genetikai és neuroanatómiai, valamint kognitív tényezőkről, amelyeknek a tipikus állapottól való eltérése pragmatikai zavarhoz vezet. Emellett meghatározza az atipikus pragmatikai működés jellegzetességeit azokban a fejlődési zavarokban, amelyekben leggyakrabban kell számolnunk a pragmatikai fejlődés zavarával is.
Intervensi Nonfaramakologik untuk Mengurangi Cemas dalam Meningkatkan Kualitas Hidup ODHA
Authors: A Sitti Shoimatul , Waluyo Agung , Yona Sri 
Published: July 2022

This study aims to explore non-pharmacological interventions that can reduce anxiety in improving the quality of life of ODHA. The research method used is a search in the online databases of PubMed, Scopus, ScienceDirect, Wiley Online, and Embase. The results of the research data were analyzed and summarized based on the effect of the intervention given on anxiety. There are three themes of non-pharmacological interventions such as yoga, reiki and massage that can have an anxiety-reducing effect. In conclusion, non-pharmacological interventions can reduce anxiety, ODHA who have a high anxiety score will have an impact on their quality of life. Non-pharmacologic interventions such as yoga, massage and reiki can be applied to people living with HIV in reducing anxiety to improve their quality of life.

Keywords: Anxiety, Quality of life, ODHA
Konseling Menyusui Berbasis Android terhadap Keberhasilan Asi Eksklusif di Masa Pandemi Covid-19
Authors: Rosa Eni Folendra 
Published: July 2022

This study examines the effect of Android-based breastfeeding counseling during the COVID-19 pandemic and the success of exclusive breastfeeding. The research design used in this study was experimental with a controlled trial design. The results showed that exclusive breastfeeding was 2.06 times more in the intervention group (android-based breastfeeding counseling) than in the control group (RR=2.06; 95% CI). In conclusion, the proportion of exclusive breastfeeding to mothers who received Android-based breastfeeding counseling was more significant than that of mothers who did not receive Android-based counseling.

Keywords: Android, exclusive breastfeeding, Breastfeeding Counseling
Latihan Aktivitas Fisik Seperti Berjalan Setiap Hari pada Pasien Hipertensi
Authors: Koharuddin Koharuddin , Maria Riri 
Published: July 2022

This study aims to determine the effect of walking physical activity on blood pressure in hypertension patients. This type of research is a systematic review, by reviewing several journals from the University of Indonesia library through CINAHL, Pubmed, Ebscohost, Springers, Wiley, and Scopus. The results of research from 11 literature searches that walking activity exercises can effectively reduce blood pressure levels, ranging from 6 minutes to 120 minutes per day, and 1200 minutes every week, can produce a better effect in hypertensive patients - the average decrease in SBP is significant between 2.6 mmHg and 22.6 mmHg. In conclusion, walking activity exercises are very useful and effective in reducing blood pressure levels, especially in hypertensive patients.

Keywords: Physical Activity, Walking, Hypertension, Brisk Walking, Jogging
Gambaran Kesehatan Lingkungan Rumah pada Pasien Tuberkulosis Paru
Authors: Yani Desy Indra , Pebrianti Riani , Purnama Dadang 
Published: July 2022

This study aims to determine the environmental health picture of TB patients in Kadungora District, Garut Regency. The method used is descriptive quantitative. The results of this study indicate a occupancy density of 56.3% which meets the requirements, unhealthy room ventilation is 18.8%, the humidity of an unhealthy patient's room is 43.8%, the temperature value in the respondent's house has a normal value of 18- 300C with a percentage of 100% and the lighting that is owned has a normal value when the lamp is turned on with a percentage of 95%. In conclusion, the density of occupancy in the homes of TB patients in the Kadungora area has densely populated houses. The room ventilation area that meets the requirements for TB patients is 26 rooms. Humidity in the house of a patient with TB in the Kadungora area that meets the requirements when the window door is opened in a room that meets the requirements of 21 rooms

Keywords: Environmental Health, Home, Pulmonary Tuberculosis
Pengembangan Kompetensi Kepemimpinan Perawat Manajer Melalui Panduan Kompetensi
Authors: Nurhani Ana , Handiyani Hanny , Rayatin Lilis 
Published: July 2022

This study aims to develop the leadership competence of nurse managers through guidelines. The method used is a case study, using an action research approach. The results showed that the head of the room needed leadership competency development on average 42% strongly agreed, 58% agreed. Analysis of the problem of optimizing the manager's leadership competence with the development of a draft guide to the manager's leadership competence as a desire to implement leadership. Conclusions, support from required fields, and things that are needed to achieve the development of a nurse manager leadership competency guide draft.

Keywords: Leadership Competence, Guide Development, Nurse Manager
Bimbingan Teknis Menyusui terhadap Pengetahuan, Keterampilan dan Efikasi Diri Ibu Menyusui
Authors: Suryanti Yuli , Galuh W Ajeng , Kusmaryati Pauline 
Published: July 2022

This study aims to determine the effect of breastfeeding technical guidance on the knowledge, skills, and self-efficacy of breastfeeding mothers. This research is pre-experimental research with the approach used as One Group Pretest-posttest. The results showed that breastfeeding technique guidance was very influential in increasing breastfeeding knowledge, skills, and self-efficacy with a value of = 0.000 (p <0.05). In conclusion, providing education about breastfeeding techniques is effective in increasing knowledge, skills, and self-efficacy in breastfeeding.

Keywords: Breastfeeding, Guidance, Self-Efficacy, Counseling
Rehabilitasi Fisik Pasca COVID-19 dalam Meningkatkan Kapasitas Fungsi Paru
Authors: Hisbulloh Latif , Irawati Dewi 
Published: July 2022

This study aims to see the effectiveness of physical activity rehabilitation in post-covid-19 patients in increasing lung function capacity. The method used is a literature review using a database, namely Google Schooler, Embase, Pubmed, and Clinical Key. The results showed that physical rehabilitation therapy was divided into two. The first is a light physical exercise carried out by doing a Short Physical Performance Battery (SPPB) as a measure of performance (time required to walk 4 meters), balance (standing for 10 seconds with legs), and lower extremity strength (time needed to stand and sit). Five times from the chair). This physical exercise is carried out as long as there are no signs and symptoms of worsening. The second therapy is yoga practice therapy which, in its implementation, can increase concentration and eliminate anxiety. In conclusion, early rehabilitation should be given to post-COVID-19 patients. Individuals with limitations due to restriction or lockdown should receive an exercise program to reduce weakness, sarcopenia, cognitive decline, and depression.

Keywords: COVID 19, Lung Function, Physical Rehabilitation
MoCA 7.1: Multicenter Validation of the First Italian Version of Montreal Cognitive Assessment
Authors: Pirani Alessandro , Nasreddine Ziad , Neviani Francesca , Fabbo Andrea , Rocchi Marco Bruno , Bertolotti Marco , Tulipani Cristina , Galassi Matteo , Belvederi Murri Martino , Neri Mirco 
Published: July 2022

Background: The early detection of neurocognitive disorders, especially when mild, is a key issue of health care systems including the Italian Dementia National Plan. The Mini-Mental State Examination (MMSE), i.e., the reference screening tool for dementia in Italian Memory Clinics, has low sensitivity in detecting mild cognitive impairment (MCI) or mild dementia. Objective: Availability of a 10-minute screening test sensitive to MCI and mild dementia, such as the Montreal Cognitive Assessment (MoCA), is relevant in the field. This study presents initial validity and reliability data for the Italian version of MoCA 7.1 that is being collected as part of a large ongoing longitudinal study to evaluate the rate of incident MCI and dementia in older adults. Methods: MoCA 7.1 and MMSE were administered to cognitive impaired patients ( n = 469; 214 with MCI, 255 with dementia; mean age: 75.5; 52% females,) and healthy older adults ( n = 123, mean age: 69.7, 64 % females). Results: Test-retest (0.945, p < 0.001) and inter-rater (0.999, p < 0.001) reliability of MoCA 7.1, assessed on randomly selected participants with normal cognition, MCI, dementia, were significant. MoCA 7.1 showed adequate sensitivity (95.3%) and specificity (84.5%) in detecting MCI compared to MMSE (sensitivity: 53.8%; specificity: 87.5%). The Area Under the Curve of MoCA 7.1 was significantly greater than that of MMSE (0.963 versus 0.742). MoCA 7.1 showed similar results in detecting both MCI and dementia. Conclusion: MoCA 7.1 is a reliable and useful tool that can aid in the diagnosis of MCI and dementia in the Italian population.
Psychiatric and Psychosocial Characteristics of a Cohort of Spanish Individuals Attending Genetic Counseling Due to Risk for Genetically Conditioned Dementia
Authors: Sobregrau Pau , Peri Josep M. , Sánchez del Valle Raquel , Molinuevo Jose L. , Barra Bernardo , Pintor Luís 
Published: July 2022

Background: Predictive genetic tests are presently effective over several medical conditions, increasing the demand among patients and healthy individuals. Considering the psychological burden suspected familial dementia may carry on individuals, assessing personality, coping strategies, and mental health could aid clinicians in findings the appropriate time for delivering genetic test results and predict compliance regarding genetic counseling and expectations towards the genetic condition depending on the outcome. Objective: To describe the psychiatric, psychological, and coping characteristics of a sample of Spanish individuals at risk of familial dementia before genetic test results were given. Methods: We included 54 first degree relatives of patients diagnosed with Alzheimer’s disease, lobar frontotemporal degeneration, or prion diseases. The NEO-FFI-R, COPE, and HADS tests evaluated personality, coping strategies, and psychological distress, respectively. Results: Anxiety and depression were below the cut-off point for mild severity. Conscientiousness and Agreeableness were the most preponderant personality factors, while Neuroticism was the least. Positive reinterpretation and Acceptance were the most frequent coping strategies, and Denial and Alcohol and drug use were the least used. Ongoing medical pathologies increased depression, while psychiatric disorders worsened psychological distress. Conclusion: Contrary to our expectations, PICOGEN candidates showed psychological distress and personality traits within normative ranges, and the use of problem-focused coping strategies prevailed over avoidance coping strategies. Nevertheless, clinicians should pay particular attention to individuals attending genetic counseling who are women, aged, and present an ongoing psychiatric disorder and psychiatric history at inclusion to ensure their mental health and adherence throughout the process.
Detecting Primary Progressive Aphasia Atrophy Patterns: A Comparison of Visual Assessment and Quantitative Neuroimaging Techniques
Authors: Franczak Stephanie , Pommy Jessica , Minor Greta , Zolliecoffer Chandler , Bhalla Manav , Agarwal Mohit , Nencka Andrew , Wang Yang , Klein Andrew , O’Neill Darren , Henry Jude , Umfleet Glass 
Published: July 2022

Background: There are now clinically available automated MRI analysis software programs that compare brain volumes of patients to a normative sample and provide z-score data for various brain regions. These programs have yet to be validated in primary progressive aphasia (PPA). Objective: To address this gap in the literature, we examined Neuroreader™ z-scores in PPA, relative to visual MRI assessment. We predicted that Neuroreader™ 1) would be more sensitive for detecting left > right atrophy in the cortical lobar regions in logopenic variant PPA clinical phenotype (lvPPA), and 2) would distinguish lvPPA ( n = 11) from amnestic mild cognitive impairment (aMCI; n = 12). Methods: lvPPA or aMCI patients who underwent MRI with Neuroreader™ were included in this study. Two neuroradiologists rated 10 regions. Neuroreader™ lobar z-scores for those 10 regions, as well as a hippocampal asymmetry metric, were included in analyses. Results: Cohen’s Kappa coefficients were significant in 10 of the 28 computations ( k = 0.351 to 0.593, p≤0.029). Neuroradiologists agreed 0% of the time that left asymmetry was present across regions. No significant differences emerged between aMCI and lvPPA in Neuroreader™ z-scores across left or right frontal, temporal, or parietal regions ( ps > 0.10). There were significantly lower z-scores in the left compared to right for the hippocampus, as well as parietal, occipital, and temporal cortices in lvPPA. Conclusion: Overall, our results indicated moderate to low interrater reliability, and raters never agreed that left asymmetry was present. While lower z-scores in the left hemisphere regions emerged in lvPPA, Neuroreader™ failed to differentiate lvPPA from aMCI.
TRPC and TRPM channels: New possible targets for cancer
Authors: Verma Priyanka , Rani Rachana , Rao Priya , Singh Anuj Kumar 
Published: July 2022

Cancer is the second most common reason for death in the world. The cancer research over four decades has been reached to the prospective on dysregulation of ions like (Ca2+, Mg2+, Na +, K+, or Cl - ) recently. These ions are orchestrated through numerous proteins, ion channels, selectively or non-selectively. However, the dysregulation of these ions and their channel expression are being reported for various diseases but here we have reviewed precisely TRP channels (TRPC and TRPM) for their role in cancer. The transient receptor potential (TRP) channels were first discovered in Drosophila melanogaster in 1989 and since then the superfamily becomes a group of 30 members under six subsections. Interestingly, we found that the TRPC (Canonical) channels, with 6 members, were explored in nine different types of cancers in last two decades. Additionally, we included the TRPM (Melastatin) subfamily and reviewed their role in cancer. Conclusively, these studies support that TRP channel-based therapies must be taken forward for clinical studies. Some channels, such as TRPC6, TRPM7 and TRPM8 were explored extensively in many cancer types which may be a potential target for cancer treatment. However, TRPM8 in lung cancer was reported for reverse association with cell proliferation, which needs to be reverified in lung cancer and other cancers. Besides, some TRPC channels are associated with store-operated calcium entry (SOCE) such as TRPC1, TRPC4 and TRPC6. Interestingly, the TRPC6 role was reported in breast cancer for modulation of Ca2+ through translocation of Orai1 and Orai3.
Effect of FLAVAnols on bone turnover markers in type 2 diabetes mellitus–post hoc analysis from a 3-month randomized placebo-controlled trial
Authors: Waqas Komal , Rashid Mardin , van der Eerden Bram C.J. , van den Berg Sjoerd A.A. , Sijbrands Eric J.G. , Berk Kirsten A. , Zillikens M. Carola 
Published: July 2022

BACKGROUND: Individuals with type 2 diabetes mellitus (T2DM) have increased fracture risk with high bone mineral density, possibly related to advanced glycation end products (AGEs) accumulation in bone. Flavanol supplementation in postmenopausal women reduced AGEs formation and decreased bone resorption markers. However, to date, these effects have not been investigated in T2DM. OBJECTIVE: We used a post hoc secondary analysis to determine the effect of monomeric and oligomeric flavanols supplementation on bone turnover markers (BTMs) in individuals with T2DM. METHODS: Eighty-three individuals with T2DM, aged 40–85 years, with microalbuminuria were enrolled from 4 trial centers in Rotterdam, the Netherlands, into a randomized, double-blind, placebo-controlled trial with renal vascular health as the primary outcome. Participants were randomized (1:1) to receive either a placebo or 200 mg of monomeric and oligomeric flavanols as intervention for three months. Serum alkaline phosphatase (ALP), type I collagen crosslinked beta C-telopeptide (β-CTx), and type I procollagen-N-propeptide (P1NP) were measured at baseline and three months. ANCOVA was performed on rank transformed BTMs at three months as the outcome, adjusting for baseline BTMs, group, age, sex, and BMI. RESULTS: Baseline characteristics did not differ between the two arms. The adjusted mean change in BTMs at three months was not different between the placebo vs. intervention arm: ALP –0.059 (–0.262–0.145) vs. 0.060 (–0.135–0.356), p = 0.41; β-CTx 0.013 (–0.205–0.231) vs. 0.100 (–0.109–0.310), p = 0.53 and P1NP 0.091 (–0.080–0.262) vs. 0.030 (–0.134–0.195), p = 0.61. There was no significant within-group change in BTMs after three months in both study arms. CONCLUSION: Supplementation with daily 200 mg of flavanols during three months, on top of usual care in individuals with T2DM, did not result in changes in BTMs compared to placebo. Future studies are needed to show whether long-term supplementation in higher dosages may positively affect BTMs in individuals with T2DM.