bluuebunny/crossref_metadata_2025_split huggingface dataset:
Gerontoorthopädie und -traumatologie bei entzündlich-rheumatischen Erkrankungen
Authors: Gaulke Ralph 
Published: February 2022

ZUSAMMENFASSUNGDie Gerontotraumatologie und -orthopädie beinhaltet nicht nur biomechanische Gesichtspunkte, wie eine verminderte Knochenqualität, rigide Weichteile und Sarkopenie, sondern auch neurologische, wie Koordinationsstörungen, Ataxie und Lähmungen, angiologische, wie Arteriosklerose, und vor allem internistische Gesichtspunkte, wie das Herz-Kreislauf-System, Mangelernährung, Diabetes mellitus, Nieren- und Leberinsuffizienz und COPD. Auch eine Hypakusis und verminderte Sehfähigkeit erhöhen das Sturzrisiko im Alter. Neben der Prophylaxe und der konservativen Therapie hat die operative Therapie bis ins hohe Alter einen hohen Stellenwert, insbesondere bei Frakturen des proximalen Femurs, welche mit einer hohen Mortalität einhergehen. Die interdisziplinäre Therapie erzielt die besten Ergebnisse für die Lebensqualität und das Überleben dieser Patienten.
Zerebrale und liquorspezifische Besonderheiten beim primären Offenwinkelglaukom und Normaldruckglaukom
Authors: Killer Hanspeter Esriel 
Published: February 2022

ZusammenfassungNeben dem Kammerwasser und dem Blut spielt auch der Liquor cerebrospinalis eine wesentliche Rolle in der Pathophysiologie des primären Offenwinkelglaukoms (POWG) und insbesondere auch beim
Normaldruckglaukom (NDG). Neben dem Liquordruck, der eine wichtige Rolle bei der Stauungspapille spielt, ist vor allem die Zusammensetzung des Liquors sowie die Fließgeschwindigkeit von
Bedeutung. Der Liquor steht sowohl mit dem Gehirn, dem Spinalkanal als auch mit dem Sehnerv im Kontakt. Bei neurodegenerativen Erkrankungen wird neben einer veränderten Zusammensetzung des
Liquors auch ein eine verlangsamte Flussgeschwindigkeit als möglicher pathophysiologischer Faktor beschrieben. Auch im perioptischen Subarachnoidalraum des Sehnervs sind bei Patienten mit
Normaldruckglaukom Veränderungen der Liquorzusammensetzung wie auch der Flussgeschwindigkeit beschrieben. Diese Befunde legen nahe, dass es sich beim primären POWG, insbesondere aber beim
NDG um einen neurodegenerativen Prozess handeln kann.
Long-COVID und Diabetes
Authors: Bornstein Stefan 
Published: February 2022

ZUSAMMENFASSUNGDas Long-COVID- oder post-acute COVID-19 syndrome stellt eine der großen Herausforderungen der Pandemie dar, welche uns in den nächsten Jahren noch in erheblichem Umfang beschäftigen wird. Umfang, Schweregrad und Auswirkungen auf unser Gesundheitssystem lassen sich zum jetzigen Zeitpunkt noch gar nicht vollständig abschätzen. 10–40 % der Menschen, die mit COVID-19 infiziert waren, leiden nach derzeitigen Untersuchungen an klinisch relevanten Symptomen des Long-COVID-Syndroms 1–3. Im Vordergrund stehen chronische Fatigue, Dyspnoe und verschiedene kognitive Symptome. Erste Untersuchungen haben gezeigt, dass insbesondere Patienten mit Übergewicht und Diabetes ein höheres Risiko für die Entwicklung klinisch relevanter Symptome im Rahmen des Long-COVID-Syndroms haben. Diabetes kann das Auftreten von Fatigue, Muskelschwäche, Sarkopenie und mikrovaskulärer, endothelialer Schäden im Rahmen der COVID-19-Erkrankung und des sich daraus entwickelten Long-COVID-Syndroms deutlich verschlechtern. Andererseits zeigen neueste Studien, dass Long-COVID und damit verbundene wiederholte Steroidgaben zu langfristigen metabolischen Störungen beitragen können. Aus diesem Grund ist gerade bei Patienten mit Post-COVID-/Long-COVID-Syndrom ein strukturiertes Diabetesprogramm mit Rehabilitation und körperlicher Betätigung sowie einer optimalen diätetischen Führung von größter Bedeutung. Die Entfernung von Auto-Antikörpern und spezifische Verfahren der therapeutischen Apherese könnten bei einzelnen Patienten zu einer deutlichen Verbesserung der Beschwerden im Rahmen des Long-COVID-Syndroms führen.
Metabolische und mentale Folgen der Pandemie
Authors: Steenblock Charlotte , Ziegler Christian , Balanzew Wladimir , Barthel Andreas , Wang Jun , Licinio Julio , Bornstein Stefan 
Published: February 2022

ZUSAMMENFASSUNGAls Hausärzte und Diabetologen werden wir in den nächsten Jahren mit den Langzeitfolgen der Pandemie zu tun haben. Neben der Viruserkrankung selbst haben die Maßnahmen zur Pandemiebekämpfung bisher noch nicht absehbare Kollateralschäden verursacht. Berichte und Studien aus allen Ländern, in denen es zu Lockdowns, Ausgangssperren, Homeoffice und Schul- bzw. Kitaschließungen kam, zeigen eine signifikante Zunahme an Übergewicht, Essstörungen, Depressionen und Angststörungen in allen Bevölkerungs- und Altersgruppen. Hierbei sind sowohl die Infizierten als auch die Nichtinfizierten betroffen. Die damit zusammenhängenden Langzeitfolgen werden unser Gesundheitssystem nachhaltig beanspruchen. Besonders bedenklich ist dabei die Tatsache, dass insbesondere die jetzige Pandemie auf die bereits vorbestehende „Pandemie“ von Übergewicht und Diabetes aufgebaut hat. Wir erzeugen damit eine weitere Zunahme der größten Risikogruppe für schwere Verläufe der Infektionskrankheiten in der Zukunft. Daher sind wir nun alle, ob im primären oder tertiären Teil der Krankenversorgungstätigkeit gefordert, dieser Post-Corona-Welle an metabolischen und mentalen Komplikationen zu begegnen. Als Ärzte müssen wir auf diese Folgen hinweisen und ausreichend Ressourcen zur Versorgung dieser dramatischen „Nachwehen“ der Pandemie schaffen. Daher ist es von großer Bedeutung, das Bewusstsein für die Schnittstelle zwischen mentalen Krankheiten, Diabetes und COVID-19 zu stärken. Da sich die Symptome von Post-COVID, Diabetes und Depression überschneiden können, besteht schließlich Bedarf an der Ausbildung von Fachpersonal in der Behandlung dieser Komorbiditäten.
The Role of Preemptive Infiltration Anesthesia in the Management of Postoperative Pain Following Septoplasty
Authors: Yener Haydar Murat , Akiner Umur , Sari Elif , Erdur Zülküf Burak , Tevetoğlu Firat , Gözen Emine Deniz 
Published: February 2022

Abstract
Introduction Septoplasty is one of the most common surgical procedures in rhinology practice. Two major problems encountered after septoplasty are pain and bleeding. Preoperative administration of analgesics before the surgical stimulus, which is the main concept of preemptive analgesia, decreases postoperative pain.
Objective The present study was designed to investigate whether preincisional lidocaine infiltration to the subperichondrial area during septoplasty surgery reduced or not postoperative pain and analgesic use.
Methods The present prospective, randomized, placebo controlled, double-blind trial was conducted on 64 consecutive patients with nasal septum deviation. Patients were randomly divided into 2 groups; the study group received 2% 20 mg lidocaine/cc (n = 31), and the control group received 6 cc 0.9% NaCl (n = 33). A standard questionnaire was given to each patient to mark his or her pain score between 0 and 10 at the 1st, 3rd, 6th, 12th, and 24th hours.
Results The mean and the range of visual analogue scale (VAS) scores of the patients in the study group at the 1st, 3rd, 12th, and 24th hours were 4.03 ± 3.08 (0–10); 3.42 ± 2.39 (0–8); 2.97 ± 2.22 (0–8); 2.87 ± 2.61 (0–9); and 1.94 ± 2.06 (0–9) respectively. The mean and the range of VAS scores of the patients in the control group at the 1st, 3rd, 12th, and 24th hours were 4.12 ± 2.7 (0–10); 3.45 ± 2.4 (0–10); 2.94 ± 2.7 (0–10); 2.79 ± 2.34 (0–10); and 1.5 ± 1.8 (0–6), respectively. The statistical analysis revealed no significant difference among the groups.
Conclusion The preemptive local anesthetic administration to the incision area and under the mucoperichondrial flap before septoplasty does not decrease the level of postoperative pain.
Exogenous application of spermidine mitigates the adverse effects of drought stress in faba bean (
Authors: Abid Ghassen , Ouertani Rim Nefissi , Ghouili Emna , Muhovski Yordan , Jebara Salwa Harzalli , Abdelkarim Souhir , Chaieb Oumaima , Ben Redjem Yosr , El Ayed Mohamed , Barhoumi Fathi , Souissi Fatma , Jebara Moez 
Published: February 2022

In Tunisia, drought stress is a major environmental factor limiting crop production and causing relatively low and unstable faba bean yields. In the present study, we explored the putative role of spermidine (0.5, 1, 1.5 and 2 mM) in ameliorating the effects of drought stress induced by polyethylene glycol (PEG-6000, −0.58 MPa) in faba bean seedlings. Drought stress reduced photosynthetic performance, chlorophyll and relative water content in leaves of faba bean variety Badii. Moreover, drought increased proline, electrolyte leakage and malondialdehyde content by inducing reactive oxygen species (hydrogen peroxide) generation in leaves. However, applying spermidine increased the activities of catalase, superoxide dismutase, ascorbate peroxidase and guaiacol peroxidase. The results show that the application of spermidine especially at a rate of 1.5 mM effectively reduces oxidative damage and alleviates negative effects caused by drought stress. In addition, exogenous spermidine increased the expression of polyamine biosynthetic enzymes’ genes (VfADC, VfSAMDC and VfSPDS), and reduced the expression of VfSPMS suggesting that exogenous spermidine can regulate polyamines’ metabolic status under drought challenge, and consequently may enhance drought stress tolerance in faba bean. Real-time quantitative polymerase chain reaction analysis revealed that some drought responsive genes (VfNAC, VfHSP, VfNCED, VfLEA, VfCAT, VfAPX, VfRD22, VfMYB, VfDHN, VfERF, VfSOD and VfWRKY) from various metabolic pathways were differentially expressed under drought stress. Overall, these genes were more abundantly transcribed in the spermidine-treated plants compared to untreated suggesting an important role of spermidine in modulating faba bean drought stress response and tolerance.
An in-frame deletion mutation in the degron tail of auxin coreceptorIAA2confers resistance to the herbicide 2,4-D inSisymbrium orientale
Authors: Figueiredo Marcelo R. A. de , Küpper Anita , Malone Jenna M. , Petrovic Tijana , Figueiredo Ana Beatriz T. B. de , Campagnola Grace , Peersen Olve B. , Prasad Kasavajhala V. S. K. , Patterson Eric L. , Reddy Anireddy S. N. , Kubeš Martin F. , Napier Richard , Dayan Franck E. , Preston Christopher , Gaines Todd A. 
Published: February 2022

SignificanceSynthetic auxin herbicides intersect basic plant developmental biology and applied weed management. We investigated resistance to 2,4-D in the Australian weedSisymbrium orientale(Indian hedge mustard). We identified a mechanism involving an in-frame 27-bp deletion in the degron tail of auxin coreceptor IAA2, one member of the gene family of Aux/IAA auxin co-receptors. We show that this deletion in IAA2 is a gain-of-function mutation that confers synthetic auxin resistance. This field-evolved mechanism of resistance to synthetic auxin herbicides confirms previous biochemical studies showing the role of the Aux/IAA degron tail in regulating Aux/IAA protein degradation upon auxin perception. The deletion mutation could be generated in crops using gene-editing approaches for cross-resistance to multiple synthetic auxin herbicides.
Scaling laws in enzyme function reveal a new kind of biochemical universality
Authors: Gagler Dylan C. , Karas Bradley , Kempes Christopher P. , Malloy John , Mierzejewski Veronica , Goldman Aaron D. , Kim Hyunju , Walker Sara I. 
Published: February 2022

Significance
Known examples of life all share the same core biochemistry going back to the last universal common ancestor (LUCA), but whether this feature is universal to other examples, including at the origin of life or alien life, is unknown. We show how a physics-inspired statistical approach identifies universal scaling laws across biochemical reactions that are not defined by common chemical components but instead, as macroscale patterns in the reaction functions used by life. The identified scaling relations can be used to predict statistical features of LUCA, and network analyses reveal some of the functional principles that underlie them. They are, therefore, prime candidates for developing new theory on the “laws of life” that might apply to all possible biochemistries.
Landscape of surfaceome and endocytome in human glioma is divergent and depends on cellular spatial organization
Authors: Governa Valeria , Talbot Hugo , Gonçalves de Oliveira Kelin , Cerezo-Magaña Myriam , Bång-Rudenstam Anna , Johansson Maria C. , Månsson Ann-Sofie , Forsberg-Nilsson Karin , Marko-Varga György , Enríquez Pérez Julio , Darabi Anna , Malmström Johan , Bengzon Johan , Welinder Charlotte , Belting Mattias 
Published: February 2022

Significance
Cancer immunotherapies, including checkpoint inhibitor blocking antibodies and antibody drug conjugates, currently revolutionize cancer treatment. However, a remaining challenge is the identification of tumor surfaceome (TS) targets for the design of more rational, individualized treatments. We have developed a procedure for unbiased mapping of TS targets in glioblastoma (GBM), i.e., the most common primary malignant brain tumor that remains among the most aggressive forms of cancer, and for which attempts to find effective treatments have failed so far. The present study provides additional layers of understanding fundamental to the future development of immunotherapy strategies, as well as procedures for proteomics-based target identification aimed at a better understanding of how to harness the TS for personalized immunotherapy.
Heritable changes in division speed accompany the diversification of single T cell fate
Authors: Plambeck Marten , Kazeroonian Atefeh , Loeffler Dirk , Kretschmer Lorenz , Salinno Ciro , Schroeder Timm , Busch Dirk H. , Flossdorf Michael , Buchholz Veit R. 
Published: February 2022

Significance

Rapid clonal expansion of antigen-specific T cells is a fundamental feature of adaptive immune responses. Here, we utilize continuous live-cell imaging in vitro to track the division speed and genealogical connections of all descendants derived from a single naive CD8
+
T cell throughout up to ten divisions of activation-induced proliferation. Bayesian inference of tree-structured data reveals that clonal expansion is divided into a homogenously fast burst phase encompassing two to three divisions and a subsequent diversification phase during which T cells segregate into quickly dividing effector T cells and more slowly cycling memory precursors. Our work highlights cell cycle speed as a major heritable property that is regulated in parallel to key lineage decisions of activated T cells.
Automorphic Bloch theorems for hyperbolic lattices
Authors: Maciejko Joseph , Rayan Steven 
Published: February 2022

Significance
Recent experiments in circuit quantum electrodynamics and electric circuit networks have demonstrated the coherent propagation of wave-like excitations on hyperbolic lattices. The negative curvature of space that underlies such lattices invalidates the familiar Bloch theorem of ordinary solid-state physics. In this work, we prove rigorous Bloch theorems for hyperbolic lattices through the identification of appropriate periodic boundary conditions. Unlike the ordinary Bloch theorem for crystalline lattices, our hyperbolic Bloch theorem is generally nonabelian in nature and involves infinitely many Brillouin zones for a single lattice. Our work initiates a chapter in band theory and establishes deep connections between condensed matter physics and algebraic geometry.
Kurarinone alleviated Parkinson's disease via stabilization of epoxyeicosatrienoic acids in animal model
Authors: Sun Cheng-Peng , Zhou Jun-Jun , Yu Zhen-Long , Huo Xiao-Kui , Zhang Juan , Morisseau Christophe , Hammock Bruce D. , Ma Xiao-Chi 
Published: February 2022

Significance
To date, no cure or preventative treatment for Parkinson’s disease (PD) has yet been developed. Here, we show that kurarinone, a natural flavonoid, alleviated parkinsonism-like symptoms induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in mice. Using a proteomics approach, we identified the soluble epoxide hydrolase (sEH) as a possible target of kurarinone’s reduction of neuroinflammation. This was supported using complementary biochemical approaches, which demonstrated that kurarinone is a high nanomolar uncompetitive inhibitor of sEH. Our findings suggest that natural products could attenuate the development of PD through inhibition of sEH.
Lack of association between pandemic chilblains and SARS-CoV-2 infection
Authors: Gehlhausen Jeff R. , Little Alicia J. , Ko Christine J. , Emmenegger Marc , Lucas Carolina , Wong Patrick , Klein Jon , Lu Peiwen , Mao Tianyang , Jaycox Jillian , Wang Eric ,   Yale IMPACT Team, Ugwu Nelson , Muenker Cate , Mekael Dilgash , Klein Rhonda Q. , Patrignelli Robert , Antaya Richard , McNiff Jennifer , Damsky William , Kamath Kathy , Shon John , Ring Aaron M. , Yildirim Inci , Omer Saad , Ko Albert I. , Aguzzi Adriano , Iwasaki Akiko , Obaid Abeer , Lu-Culligan Alice , Nelson Allison , Brito Anderson , Nunez Angela , Martin Anjelica , Watkins Annie , Geng Bertie , Kalinich Chaney , Harden Christina , Todeasa Codruta , Jensen Cole , Kim Daniel , McDonald David , Shepard Denise , Courchaine Edward , White Elizabeth B. , Song Eric , Silva Erin , Kudo Eriko , DeIuliis Giuseppe , Rahming Harold , Park Hong-Jai , Matos Irene , Nouws Jessica , Valdez Jordan , Fauver Joseph , Lim Joseph , Rose Kadi-Ann , Anastasio Kelly , Brower Kristina , Glick Laura , Sharma Lokesh , Sewanan Lorenzo , Knaggs Lynda , Minasyan Maksym , Batsu Maria , Petrone Mary , Kuang Maxine , Nakahata Maura , Campbell Melissa , Linehan Melissa , Askenase Michael H. , Simonov Michael , Smolgovsky Mikhail , Sonnert Nicole , Naushad Nida , Vijayakumar Pavithra , Martinello Rick , Datta Rupak , Handoko Ryan , Bermejo Santos , Prophet Sarah , Bickerton Sean , Velazquez Sofia , Alpert Tara , Rice Tyler , Khoury-Hanold William , Peng Xiaohua , Yang Yexin , Cao Yiyun , Strong Yvette 
Published: February 2022

Significance
Chilblain diagnoses have increased during the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic and have been attributed to viral infection and a subsequent robust antiviral immune response. As a result, providers have managed these cases differently than idiopathic chilblains, which are associated with cold exposure. The relationship between pandemic chilblains and SARS-CoV-2 infection, however, remains unclear as most patients do not test positive for SARS-CoV-2–specific PCR or antibodies. To better understand this disconnect, we enrolled cases of pandemic chilblains in a study and performed detailed immune profiling of antibody and T cell responses. Additionally, we compared immunohistochemical staining of pandemic chilblains with prepandemic tissues. Our results do not support SARS-CoV-2 as the cause of the increased chilblain incidence.
The monolingual bias
Authors: Genesee Fred 
Published: February 2022

Abstract
The developmental trajectory of monolinguals has often been used as the benchmark against which the progress of
all language learners is assessed and understood, and the abilities of monolinguals are used to define the native-like competence
that is widely cited as the ultimate goal for all language learners. Moreover, language learning standards and curricula to guide
language teaching and learning in school, as well as frameworks and strategies for assessing language learner outcomes in school,
have all been shaped in significant ways by a monolingual bias. In this article, I critically examine assumptions underlying the
monolingual bias and review findings from research on preschool and early-school-age learners who acquire language under diverse
circumstances. Explanations that go beyond the monolingual bias are proposed for findings of differences between children who
learn language under diverse circumstances and monolingual children. I argue that current research supports the view that there
are alternative pathways to becoming language competent.
Environmental safety of the Privolzhsky Federal District: problems and prospects for implementation
Authors: Gavrilov O E , Eremeeva S S , Karaganova N G , Kazakov A V , Dimitriev A V 
Published: February 2022

Abstract
At the present stage, an important part of the social development of both the country as a whole and its individual territorial entities is its sustainable development. There is no one who doubts that a high level of socio-economic development also puts forward society increased demands in the field of ecology, protection and quality of the environment. Sustainable development of any territorial entity presupposes the integration of economic, environmental and social issues and should solve the following main tasks: maintaining economic growth, social development, effective solution of environmental protection problems, rational use and reproduction of natural resources. First of all, this is due to the growing environmental hazard for the territory, nature and society and, as a result, ensuring their environmental safety at all administrative levels - from state to municipal. With a wide variety of landscape-climatic, natural-resource, demographic, economic, ecological conditions, even within one subject, ensuring the environmental safety of federal districts is a very difficult task. The sustainable and safe development of the district as a whole should be considered, first of all, from the standpoint of life favorable environment, maintaining the ecological and economic balance for business development, maintaining the quality of life and population health.
Effect of tillage on the content of nitrate nitrogen in the arable layer and the yield of spring wheat
Authors: Romanov V N , Kozulina N S , Vasilenko A V 
Published: February 2022

Abstract
Experimental data on the study of the content of nitrate nitrogen in the soil at the dump minimum and zero farming systems are presented. Evaluation of various systems of soil cultivation allows us to note the tangible energy efficiency of resource-saving technologies and assess the possibilities of introducing them into production. In our opinion, the use of new tools and mechanisms for soil cultivation will help to reduce the cost of soil cultivation.
Ensuring the environmental safety of food when using biological products in the protection of cabbage agrocenosis
Authors: Apazhev A K , Shekikhachev Y A , Hazhmetov L M , Didanova E N , Kurzhiev Kh G 
Published: February 2022

Abstract
The use of chemical means of protecting plants from diseases and pests to increase yields and improve the presentation of the product leads to negative consequences. The main one is the accumulation of chemical residues in products and the release of resistant forms of pathogens. The use of microbial antagonists that suppress the development of phytopathogenic fungi is considered as an alternative method of plant protection. Biological preparations for suppressing plant diseases are based on antagonist microorganisms, hyperparasites, and biota metabolites. An increase in the share of biological protection and a decrease in the share of the use of agrochemicals in the plant protection system contributes to the improvement of the socio-ecological situation. The search for technological methods for reducing the frequency of treatments is especially important for the cabbage culture. In this regard, this article evaluates the effectiveness of biological products in protecting cabbage agrocenosis and increasing productivity.