bluuebunny/crossref_metadata_2025_split huggingface dataset:
Treating Inferior Pole Fracture of Patella with Hand Plating System: First Clinical Results
Authors: Ma Xiang‐Yu , Cui Dong , Liu Bing , Wang Zheng , Yu Hai‐Long , Yuan Hong , Xiang Liang‐Bi , Zhou Da‐Peng 
Published: November 2022

ObjectiveInferior pole fractures of patella are notorious fractures where it is difficult to obtain rigid internal fixation by conventional methods. The objective of the study was to introduce the Hand Plating System (HPS), which was a novel surgical technique for inferior pole fractures of patella, and to report the radiological and clinical outcomes following the application of the surgical technique.MethodsThe study was designed as a retrospective cohort study. Between July 2017 and December 2018, 30 patients who were diagnosed with inferior pole fracture of the patella without additional orthopaedic injuries were enrolled in this case series. After X‐ray and 3D‐CT examinations, all patients underwent open reduction and internal fixation by HPS with or without supplementary cannulated screw and lag screw stabilization. The bony union time, final range of motion (ROM), Bostman score, visual analog scale (VAS), and complications were measured as the clinical outcomes under a minimum of 12 months of follow‐up.ResultsAll of the operations went well with the mean operative time of 76.2 ± 15.3 min. Bony union achieved in all the cases at an average of 9.5 ± 1.4 weeks after surgery. There was no loss of reduction, fixative failure, or surgical implant removal during follow‐up. The average range of motion 1 year postoperatively was 0°–123.3°. The mean Bostman Score at the last follow‐up was 26.8 ± 2.1 with the satisfactory rate of 100%. The pain feeling during walking as measured by VAS averaged at 0.9 ± 1.3. No complications developed except for one case of poor incision healing, which healed eventually after surgical debridement.ConclusionsHPS was demonstrated as a secure fixation and as a kind of tension band for inferior pole fractures of the patella. Satisfactory recovery of knee function and low complication rate, including no need for hardware removal, could be expected.
Phenotyping of immediate‐type food allergies based on 10 years of research: A latent class analysis
Authors: Takahashi Kyohei , Yanagida Noriyuki , Itonaga Takaaki , Nishino Makoto , Nagakura Ken‐ichi , Ogura Kiyotake , Sato Sakura , Ebisawa Motohiro 
Published: November 2022

AbstractBackgroundFood allergy is a disease with a diverse and variable natural history, and some patients may react to two or more food antigens. This study aimed to classify and characterize the long‐term prognosis of infantile‐onset, immediate‐type food allergies, focusing on three major antigens in Japan: egg, milk, and wheat.MethodsAll children who visited our hospital with food allergies, including suspected cases, were prospectively registered in our medical database. Among the children in this database, subjects registered by the age of 1 year with immediate‐type symptoms or sensitization to the above three antigens were included. The course of the subjects up to the age of 6 years was analyzed. Cox regression analysis and repeated‐measures latent class analysis (LCA) were performed to reveal risk factors and tolerance patterns for food allergies.ResultsWe included 915 patients with immediate‐type food allergy symptoms and 276 sensitized asymptomatic patients in this study. The number of patients with immediate‐type symptoms to egg, milk, and wheat was 609, 443, and 235, respectively. The number of patients with multiple food allergies was 302. The proportion of patients with tolerance to egg, milk, and wheat at 6 years of age was 74%, 69%, and 75%, respectively. LCA revealed 7 classes of prognosis for food allergies. The largest class was transient egg allergy alone (19.6%), and there were severe cases of multiple food allergies (6.5%).ConclusionsThis study demonstrated the prognosis of food allergy classes in Japan, including multiple food allergies, with 7 classes with its own characteristics.
Can non‐directed living liver donation help improve access to grafts and correct socioeconomic disparities in pediatric liver transplantation?
Authors: Yoeli Dor , Feldman Amy G. , Choudhury Rashikh A. , Moore Hunter B. , Sundaram Shikha S. , Nydam Trevor L. , Wachs Michael E. , Pomfret Elizabeth A. , Adams Megan A. , Jackson Whitney E. 
Published: November 2022

AbstractBackgroundEach year, children die awaiting LT as the demand for grafts exceeds the available supply. Candidates with public health insurance are significantly less likely to undergo both deceased donor LT and D‐LLD LT. ND‐LLD is another option to gain access to a graft. The aim of this study was to evaluate if recipient insurance type is associated with likelihood of D‐LLD versus ND‐LLD LT.MethodsThe SRTR/OPTN database was reviewed for pediatric LDLT performed between January 1, 2014 (Medicaid expansion era) and December 31, 2019 at centers that performed ≥1 ND‐LLD LDLT during the study period. A multivariable logistic regression was performed to assess relationship between type of living donor (directed vs. non‐directed) and recipient insurance.ResultsOf 299 pediatric LDLT, 46 (15%) were from ND‐LLD performed at 18 transplant centers. Fifty‐nine percent of ND‐LLD recipients had public insurance in comparison to 40% of D‐LLD recipients (p = .02). Public insurance was associated with greater odds of ND‐LLD in comparison to D‐LLD upon multivariable logistic regression (OR 2.37, 95% CI 1.23–4.58, p = .01).ConclusionsND‐LLD allows additional children to receive LTs and may help address some of the socioeconomic disparity in pediatric LDLT, but currently account for only a minority of LDLT and are only performed at a few institutions. Initiatives to improve access to both D‐LLD and ND‐LLD transplants are needed.
Fusarium isolates from Belgium causing wilt in lettuce show genetic and pathogenic diversity
Authors: Claerbout Jolien , Van Poucke Kris , Mestdagh Hanna , Delaere Ilse , Vandevelde Isabel , Venneman Sofie , Decombel An , Bleyaert Peter , Neukermans Jenny , Viaene Nicole , Heungens Kurt , Höfte Monica 
Published: November 2022

AbstractFusarium oxysporum f. sp. lactucae race 4 causes vascular necrosis and wilting of lettuce. First observed in Belgium in 2015, the lack of disease resistance in commercial cultivars allowed this pathogen to spread to nearly the entire Belgian production area within 4 years. Different levels of disease development were observed in different commercial greenhouses. To help explain this variation, we collected 78 Fusarium isolates and characterized them both physiologically and genetically. Molecular race identification indicated that 91% of the isolates belonged to race 4, while 6% of the isolates belonged to race 1, which was not previously reported in Belgium. Pathogenicity assays using differential cultivars confirmed the molecular race assignment of selected isolates. Cultivar Patriot was identified as a suitable new differential cultivar to race 4. Race 4 isolates were more aggressive than race 1 isolates at 24°C, but only when using chlamydospore inoculum instead of a root dip assay containing microconidia. Variation in pathogenicity and aggressiveness of the races may explain differences in disease development in commercial greenhouses. Based on genotyping‐by‐sequencing (GBS), race 1 and race 4 isolates were highly similar to reference isolates. Fusarium curvatum, F. oxysporum f. sp. tulipae and F. oxysporum f. sp. rhois were phylogenetically separated from F. oxysporum f. sp. lactucae races 1 and 4 based on the GBS data, but not when using multilocus sequence data. Within F. oxysporum f. sp. lactucae race 4, the GBS data differentiated two rather homogeneous groups, suggesting at least two introductions. However, the two groups did not differ in aggressiveness.
Immune checkpoint inhibitors in advanced cutaneous squamous cell carcinoma: A systemic review and meta‐analysis
Authors: Zhang Haoran , Zhong Ai , Chen Junjie 
Published: November 2022

AbstractBackgroundTo evaluate the immune checkpoint inhibitors (CPI) for the treatment of patients with advanced cutaneous squamous cell carcinoma (CSCC).Materials and methodsA meta‐analysis was conducted, and the efficacy and safety of CPI were assessed.ResultsA total of 13 studies with 980 patients were included. The pooled objective response rate (ORR) and disease control rate were 47.2% and 64.4%, separately. In addition, patients with primary tumor located in head and neck (odds ratio [OR]: 0.374, 95% confidence interval [CI]: 0.219–0.640, p < 0.001) and positive expression of programmed death ligand 1 (OR: 0.364, 95% CI: 0.158–0.842, P = 0.018) had superior ORR during CPI treatment. The incidence of progression free survival at 6 and 12 months was 59.3% and 52.8%, and 80.6% and 76.4% for overall survival. As for safety, the overall incidence of adverse events with all grades and 3–4 grade was 76.9% and 20.2%.ConclusionsOur systematic review confirmed the satisfying efficacy and acceptable toxicity of CPI for advanced CSCC.
Diagnostics to support mycetoma management—Development of two target product profiles
Authors: Fongwen Noah , Asiedu Kingsley B. , Bakhiet Sahar , Bonifaz Alexandro , Cruz Israel , Argaw Daniel , Estrada‐Chavez Guadalupe , Fahal Ahmed H. , Litvintseva Ana , Marks Michael , Salinas‐Carmona Mario C. , Sow Doudou , van de Sande Wendy W. J. 
Published: November 2022

AbstractObjectiveMycetoma is a neglected tropical disease caused by more than 70 different microorganisms and identified by the WHO as one of the high‐priority diseases for developing diagnostic tests. To ensure the production of diagnostic assays for use by clinical staff in endemic regions, target product profiles (TPPs) were designed.MethodsWe describe the development of two TPPs: one for a diagnostic test able to identify the causative agent of mycetoma and another that would determine when treatment could be stopped. The TPPs were developed by considering product use, design, performance, product configuration and costs.ResultsVersion 1.0 TPPs for two uses were posted by WHO for a 1‐month online public consultation on 25 October 2021, and the final TPP was posted online on 5 May 2022.ConclusionA major difficulty encountered in developing both TPPs was the large number of agents able to cause mycetoma and the lack of specific biomarkers for most of them.
MRI ischemic and hemorrhagic lesions in arterial and venous territories characterize central nervous system intravascular lymphoma in dogs
Authors: Mattei Chiara , Oevermann Anna , Schweizer Daniela , Guevar Julien , Maddox Thomas W. , Fleming Kathryn L. , Ricci Emanuele , Rosati Marco , Biserni Roberta , IV John F. Griffin , Rupp Angie , Gutierrez‐Quintana Rodrigo , Masseau Isabelle , Newkirk Kimberly M. , Hecht Silke , Specchi Swan 
Published: November 2022

AbstractIntravascular lymphoma (IVL) is characterized by the proliferation of large malignant lymphocytes within the lumen of blood vessels. This retrospective, multi‐center, case series study aimed to describe the MRI features of confirmed central nervous system IVL in dogs and compare them with histopathological findings. Medical record databases from seven veterinary centers were searched for cases of histologically confirmed IVL. Dogs were included if an MRI was performed. The MRI studies and histopathology samples were reviewed to compare the MRI changes with the histopathological findings. Twelve dogs met the inclusion criteria (12 brains and three spinal cords). Imaging of the brains revealed multifocal T2‐weighted/FLAIR hyperintense and T1‐weighted iso‐hypointense lesions, with variable contrast enhancement; areas of abnormal diffusion both in arterial and venous territories in diffusion‐weighted imaging; and meningeal enhancement. On gradient echo images (GRE), the changes comprised tubular susceptibility artifacts, consistent with the “susceptibility vessel sign”, and additional variably sized/shaped intraparenchymal susceptibility artifacts. Spinal cord lesions presented as fusiform T2‐weighted hyperintensities with scattered susceptibility artifacts on GRE and variable parenchymal and meningeal contrast enhancement. On histopathology, subarachnoid hemorrhages and neuroparenchymal areas of edema and necrosis, with or without hemorrhage, indicating ischemic and hemorrhagic infarctions, were found. These lesions were concurrent with severely dilated meningeal and parenchymal arteries and veins plugged by neoplastic lymphocytes and fibrin. Due to the unique angiocentric distribution of IVL, ischemic and hemorrhagic infarcts of variable chronicity affecting both the arterial and venous territories associated with thrombi formation can be detected on MRI.
Practical Procedure of Test Temperature Selection for Mini-C(T) Master Curve Evaluation
Authors: Yamamoto Masato , Sakuraya Seiji , Kitsunai Yuji , Kirk Mark 
Published: November 2022

Abstract
The use of 4 mm thickness Mini-C(T) specimens for Master Curve evaluation is drawing attention as a possible alternative / supplemental surveillance test method to current Charpy-based approaches in on-going efforts to update JEAC4201[1]. Obtaining a “valid” To per ASTM E1921 [2] and JEAC4216 [3] is a challenge for the Mini-C(T) because its tests must be performed at a low temperature relative to To to stay below the plasticity limit (KJclimit) of the testing standards while remaining above another limit on minimum test temperature (To – 50 °C) imposed by the testing standards. Minimizing the number of censored data caused by the violation of the KJclimit requirement is important in practical surveillance testing applications, since only a limited number (e.g., 12) of specimens may be available. Therefore, finding the appropriate test temperature within the first few specimens tested is essential. In this paper, the authors develop a KJc test temperature selection algorithm to maximize the chance of obtaining an E1921 and JEAC4216-valid To value with 12 or fewer tests. By the combined consideration of rejecting fewer specimens for being conducted below the low-temperature limit and having fewer specimens censored due to excess plasticity, we assumed that the test temperature of the next specimen in a series could be identified as the intersection of the KJclimit curve and the 98% tolerance bound of the KJc distribution, which is determined from an estimate of To made using already tested specimens. The appropriateness of this assumption is confirmed by a series of Monte-Carlo calculations, which demonstrates that this approach produces a valid To by testing 12 Mini-C(T)s &gt; 98 % of the time. The study validated this testing reliability for a realistic range of yield stress and To values for reactor pressure vessel steels.
Combined Effect of Pressure, Temperature and Soil Stiffness on Pipeline Strain Demand in Geohazard Zones
Authors: Allouche Ismael , Zheng Qian , Yoosef-Ghodsi Nader , Fowler Matthew , Adeeb Samer 
Published: November 2022

Abstract
Pipelines subject to ground deformations produced by geohazard loads carry high importance on pipeline analysis, design, and assessment due to risk of structural failure. An appropriate approach for evaluation is the finite element method (FEM), providing efficient and sophisticated results. Methods proposed by Zheng et al. (2021) using finite element analysis (FEA) software Abaqus/Standard provide highly accurate results by simulating a displacement-controlled analysis of buried steel pipes subject to ground displacement of varying magnitudes and direction. This paper aims to further develop this pipe strain demand assessment by including variable effects of internal pressure and temperature of steel pipes buried in soils of different stiffness. The developed strain demand criterion considers inelastic material behaviour for different grades of steel pipe, as well as bi-linear soil force-displacement interaction, accounting for soil plasticity (ALA, 2001). Assuming the effects of thermal expansion are negligible prior to ground motion initiation, the pipe loads can be assessed by modelling a pipeline with initial temperature and pressure loads, followed by a ground motion in a series of steps. Several case studies were performed by modelling an X65 grade pipeline subject to ground displacements varying from 100 to 1000 mm, across a length at the midsection of the pipe. Simulations are assessed with a specified temperature increase, and internal pressure required to induce an operating hoop stress of up to 80% of the specified minimum yield strength (SMYS). By assessing the pipeline in soils of different stiffness (low, intermediate, high) at different increments of ground displacement, an accurate representation of the material stress/strain response can be acquired for each respective case. This research may provide guidance for further studies of pipelines involving internal pressure & temperature.
Obtaining Low-Cost Estimates of the Master Curve Index Temperature T0 From Existing Information
Authors: Kirk Mark , Miura Naoki , Skinko Tomoki , Yamamoto Masato 
Published: November 2022

Abstract
The Master Curve and its index temperature To have, over the last three decades, gained more and more acceptance in Codes, Standards, and the regulatory frameworks of different countries. For example, the Japanese Electric Association Code (JEAC) 4206 permits use of To-based index temperatures. In the United States RTTo is directly part of Section XI of the ASME Code while use of To along with extended Master Curve techniques is permitted via Code Case N-830-1. Similarly, To is permitted within both the German and the Swiss regulatory frameworks. One barrier to wider use of Master Curve/ To-based methods is the need to perform fracture toughness (KJc) tests using often limited supplies of irradiated or archive materials to determine To. While recent advances in testing technology permit the use of “mini” compact tension specimens, four of which can be machined from one-half of a broken Charpy specimen, the testing and associated engineering and regulatory analysis still represents an additional cost. Fortunately, a variety of methods exist to estimate To from prior information before any additional KJc testing is conducted. This paper will review these methods, which rely on existing information about the material type, limited but not yet valid KJc data sets, and/or Charpy data that is known through reactor pressure vessel surveillance programs. While not a replacement for direct To testing of plant materials these methods can estimate the likely range of To, which can help determine the materials for which additional testing is likely to produce the most benefit.
Development of a Technical Basis for Code Case N-914, “Accounting for the Effect of Embrittlement on Fracture Toughness Properties Used in Evaluations of Pressure Boundary Materials in Class 1 Ferritic Steel Components, Section XI, Division 1”
Authors: Kirk Mark , Erickson Marjorie , Long Elliot J. 
Published: November 2022

Abstract
Section XI of the ASME Boiler and Pressure Vessel Code includes methods to analyze the continued operating safety of nuclear power plant components. For the reactor pressure vessel (RPV) a means to account for the effects of neutron irradiation embrittlement on the mechanical properties of vessel steels constitutes a key part of this analysis. Nevertheless, Code guidance on this topic remains imprecise. Over time regulations in various countries have filled this gap. While functional, this practice means that the structural integrity practices for nuclear RPV safety management depend on an amalgam of Code and regulatory documents. This diminishes the clarity with which safety margins are addressed and inhibits adoption of new technologies for fracture toughness and embrittlement characterization. During the February 2019 ASME Code week, the Section XI Working Group on Operating Plant Criteria (WGOPC) initiated an effort to develop a Code Case to address this deficiency. This paper summarizes an Electric Power Research Institute Report (MRP-462) recently provided to the WGOPC as a single source technical basis for the proposed Code Case on this topic. The report reviews relevant previous national and international work, both within the Code as well as licensing applications made using Master Curve techniques. The report proposes a single, unified, method to estimate an irradiated reference temperature (RTIRRAD) that can be used to position a Code-approved bounding curve (either a RTNDT or RTTo indexed KIc curve, or a T0 indexed 5th percentile Master Curve) using whatever input information (Charpy-based or Master Curve-based) is available.
Finite Element Analysis of Ring Compression Testing for Used Nuclear Fuel Cladding
Authors: Han Zenghu , Billone Michael C. , Liu Yung Y. 
Published: November 2022

Abstract
The performance of used nuclear fuel (UNF) (i.e., cladding integrity, fuel retrievability, transportability, and cladding embrittlement) is considered important to the safety of both extended long-term dry storage and subsequent transportation for final disposition. Analytical analysis for UNF structural performance under storage and transportation conditions requires mechanical property data for the cladding materials (e.g., stress-strain relationships and failure limits). However, currently available mechanical properties and correlations are not sufficient because they are primarily based on uniaxial tension tests and pressurized-tube tests of cladding materials with only circumferential hydrides and are not suitable for cladding materials with radial hydrides. Ring compression testing (RCT) has become a very useful method for measuring the relative ductility of cladding and determining the ductility transition temperature of cladding materials. The results of RCT can be used to assess the mechanical behavior of cladding materials and determine the effects of burnup, hydride orientation, and temperature to support the development of the technical basis for extended storage and transportation of high-burnup fuel. Finite element analysis (FEA) has been used to characterize the stress state associated with RCT and to facilitate a better understanding of the deformation and the failure mechanisms of the cladding ring during RCT. Three-dimensional finite element (3D FE) models have been constructed using the commercial FE computer code ABAQUS™; the FE models include RCT machine stiffness, elastic and anisotropic plastic stress-strain properties, and large strain capability, and these models are used to simulate cladding rings subjected to RCT hoop-bending loading. Useful information regarding the material properties and behavior can be extracted by FE simulation of cladding RCT. In this paper, applications of FEA to RCT are described, and the limitations are also discussed.