bluuebunny/crossref_metadata_2025_split huggingface dataset:
Novel Insights into the Important Role of Leptin in Modulating the
Pathological Development of Fibrotic-related Diseases
Authors: Kang Huiyuan , Lai Min , Yao Yan’er , Wang Bin , Su Xin , Cheng Ye 
Published: November 2022

Abstracts:
Leptin, as one of the most important cytokines within the circulation, has
been confirmed to play a vital role in the hypothalamus of the central nervous system
(CNS), which could modulate energy homeostasis by suppressing food intake. Furthermore,
leptin could also influence cell metabolism by acting directly on the leptin
receptor, which is a relatively small peptide and is mainly produced and released by fat
tissue in mammals. On the other hand, the excessive extracellular matrix (ECM) could
induce damage in normal tissues or organ structures, which might further induce fibrotic
development in multiple tissues or organs, including the liver, heart, and kidneys.
Notably, the sustainable development of fibrosis promotes the structural lesion and
functional decline of different organs, which subsequently threatens human health and
poses serious risks to human life. Emerging evidence has shown that leptin plays an
important role in the fibrotic progression within multiple tissues and organs in mammals
and has an alleviating effect on fibrosis. Concerning this notion, it has been proposed
that leptin could be identified as a vital therapeutic strategy for fibrotic progression
in clinical practice. Consequently, this review summarized the potential mechanisms
of leptin in modulating fibrotic development in diverse tissues and organs to
provide a theoretical basis for treating fibrotic-related diseases. In addition, the potential
mechanisms whereby leptin affects the development of fibrosis were also summarized
in the current review.
Evaluation of Oral Dryness and the Salivary-flow Rate in Patients with Oral Lichen Planus
Authors: Assapattarapun Varisa , Talungchit Sineepat , Jirawechwongsakul Pimporn , Taebunpakul Patrayu 
Published: November 2022

Background and Objectives:
Oral lichen planus (OLP) is a common T-cell-mediated inflammatory oral mucosal disease. One of the complaints among OLP patients is xerostomia. However, the relationship between oral dryness and a decreased salivary-flow rate in these patients is not yet conclusive. So, we investigated oral dryness and the salivary-flow rate in OLP patients using various measurements.

Material and Methods:
Thirty OLP patients and 30 controls were included. The oral-dryness symptoms were collected using the Xerostomia Inventory (XI) and Bother Index (BI). The salivary-flow rate was measured using a Modified Schirmer Test (MST) and the spitting method. The clinical signs of dry mouth were determined by the clinical oral-dryness score (CODS). The Thongprasom score was used to evaluate the severity of OLP. The data were analyzed using the Mann-Whitney U test and Spearman’s rank correlation coefficient.

Results:
The XI score and BI score in the OLP group were significantly higher than in the control group. However, CODS, MST, the unstimulated salivary-flow rate, and the stimulated salivary-flow rate were not significantly different between the two groups. There was no correlation between oral dryness and the salivary-flow rate in OLP patients. The severity of OLP was also not correlated to oral dryness and the salivary-flow rate.

Conclusion:
OLP patients had more complaints about mouth dryness than the controls. However, the salivary-flow rates between the two groups were not different. Additionally, the severity of OLP was not related to dry mouth or the salivary-flow rate. The possible reasons for oral dryness among people with OLP require further investigation.
Evaluating the Cost-Effectiveness of Plastic Surgery Based on the Satisfaction with Quality of Life and Nasolabial Appearance in Thai Preteens with Cleft Lip and Palate
Authors: Surakunprapha Palakorn , Pradubwong Suteera , Jenwitheesuk Kamonwan , Pisek Poonsak , Chowchuen Bowornsilp 
Published: November 2022

Background:
Cleft Lip and Palate (CLP) negatively affect the quality of life (QoL) and nasolabial appearance, especially in preteen patients who start to be interested in their own appearance and society.

Objective:
The objective of this study is to evaluate the cost-effectiveness of plastic surgery for Thai preteen CLP patients through their satisfaction with their QoL and nasolabial appearance.

Methods:
A cross-sectional study covered purposively selected 30 samples aged between 8 and 12 years old.Their satisfaction with their QoL and appearance was reflected through an interview and a questionnaire with the cooperation of their parents as their caregivers including satisfaction with their nasolabial appearance evaluated by five experts. They compared the photos of patients’nasolabial appearance with those of normal faces of children of the same age using 5-rating scales.

Results:
General findings showed 53.3% of samples were male patients with mostly (63.3%) UCLP whose parents were mainly (73.3%) poor, so they relied on government financial supports for the treatment. Only some (15%) earned up to 5,001 to 10,000 baht per month because of their low education with just high school level. Specific findings indicated the overall satisfaction with QoL through five dimensions at average level (3.26±1.39). This was based on the satisfaction with the center services, the overall treatments, the medical additional costs, parental satisfaction with psychosocial effects including concerns about the impacts of CLP on the family ranged from high to low i.e. 4.30±0.98, 3.72±1.15, 3.70±1.14, 3.33±1.08 and 2.81±1.46 respectively. Moreover, five experts trended to be highly satisfied with patients’ nasolabial appearance by rating it from Good (53.3%) to Fair (43.43%) with only Poor (3.3%).

Conclusion:
The good cost-effectiveness of the surgery was represented through the average and high satisfaction of CLP patients with their QoL and their appearance respectively indicating the absence of disability weights for these treated CLP patients.
FASN Inhibitors Enhance Bestatin-Related Tumor Cell Apoptosis
Through Upregulating PEPT1
Authors: Chen Shu-zhen , Ni Jun , Shang Yue , Wang Wen-die , Wang Chen , Wang Ai-min , Li Gao-jie 
Published: November 2022

Background:
Fatty acid synthase (FASN) is generally over-expressed in human tumor
tissues and catalyzes de novo synthesis of fatty acids on which tumor cells depend. Bestatin, an
inhibitor of aminopeptidase/CD13, is one of the dipeptide substrates for the human oligopeptide
transporter 1 (PEPT1).

Objectives:
In the current study, we aimed to uncover the role of FASN inhibitors in bestatin-induced tumor cell apoptosis and the underlying mechanism, extending our understanding of the correlations between FASN and PEPT1 in cancer and providing a new strategy for tumor targeted treatment.

Methods:
Cerulenin, orlistat and siRNAs were applied to inhibit FASN. The cell viability and
apoptosis were assessed with MTT (thiazolyl blue tetrazolium bromide) assays and annexin VFITC/
PI staining with flow cytometry analysis. Western blot and qRT-PCR analysis were used to
detect the protein levels and mRNA levels of the indicated genes in tumor cells, respectively.
Protein degradation or stability was examined with cycloheximide chase assays. CD13 activity
was detected by gelatin zymography. The HT1080 and C26 xenografts models were conducted
to assess the efficacy in vivo.

Results:
In the current study, we found that inhibiting FASN by cerulenin and orlistat both augmented
the effects of bestatin in decreasing tumor cell viability. Cerulenin increased the apoptosis
rates and enhanced the cleavage of PARP caused by bestatin. Furthermore, cerulenin, orlistat
and siFASNs markedly elevated PEPT1 protein levels. Indeed, cerulenin induced the upregulation
of PEPT1 mRNA expression rather than affecting the protein level after the cells were
treated with CHX. And Gly-Sar, a typical competitive substrate of PEPT1, could attenuate the
augment of bestatin-induced cell killing by cerulenin. Moreover, synergistic restrain of tumor
growth accompanied by a reduction of Ki-67 and increment of TUNEL was significantly
achieved in the xenograft models. Interestingly, no clear correlation was observed between the
CD13 with FASN and/or PEPT1 in tumor cells.

Conclusion:
FASN inhibitors facilitate tumor cells susceptible to bestatin-induced apoptosis involving
the up-regulation of PEPT1 at the mRNA translation level and the transport of bestatin
by PEPT1, emerging as a promising strategy for tumor targeted therapy.
Modeling Inflammatory Bowel Disease by Intestinal Organoids
Authors: Di Giorgio Cristina , Roselli Rosalinda , Biagioli Michele , Bordoni Martina , Ricci Patrizia , Zampella Angela , Distrutti Eleonora , Donini Annibale , Fiorucci Stefano 
Published: November 2022

Abstract:
Inflammatory bowel disease (IBD) is a chronic and relapsing disease caused by a
dysregulated immune response to host intestinal microbiota that occurs in genetically predisposed
individuals. IBD encompasses two major clinical entities: ulcerative colitis (UC), limited to the
colonic mucosa, and Crohn's disease (CD), which might affect any segment of the gastrointestinal
tract. Despite the prevalence of IBD increasing worldwide, therapy remains suboptimal, largely
because of the variability of causative mechanisms, raising the need to develop individualized
therapeutic approaches targeted to each individual patient. In this context, patients-derived intestinal
organoids represent an effective tool for advancing our understanding of IBD’s pathogenesis.
Organoid 3D culture systems offer a unique model for dissecting epithelial mechanisms involved
IBDs and testing individualized therapy, although the lack of a functional immune system and a
microbiota, two driving components of the IBD pathogenesis, represent a major barrier to their
exploitation in clinical medicine. In this review, we have examined how to improve the translational
utility of intestinal organoids in IBD and how co-cultures of 3D or 2D organoids and immune
cells and/or intestinal microbiota might help to overcome these limitations.
A Review of Preclinical Tools to Validate Anti-Diarrheal Agents
Authors: Sarma Rajdeep , Shakya Anshul , Karmakar Arka , Ghosh Surajit Kumar , Bhat Hans Raj , Ghimire Neha , Rahman Obaidur 
Published: November 2022

Background:Since their inception, preclinical experimental models have played an important role in investigating and characterizing disease pathogenesis. These in vivo, ex vivo, and in vitro preclinical tests also aid in identifying targets, evaluating potential therapeutic drugs, and validating treatment protocols.Introduction:Diarrhea is a leading cause of mortality and morbidity, particularly among children in developing countries, and it represents a huge health-care challenge on a global scale. Due to its chronic manifestations, alternative anti-diarrheal medications must be tested and developed because of the undesirable side effects of currently existing anti-diarrheal drugs.Methods:Several online databases, including Science Direct, PubMed, Web of Science, Google Scholar and Scopus, were used in the literature search. The datasets were searched for entries of studies up to May, 2022.Results:The exhaustive literature study provides a large number of in vivo, in vitro and ex vivo models, which have been used for evaluating the mechanism of the anti-diarrheal effect of drugs in chemically-, pathogen-, disease-induced animal models of diarrhea. The advances and challenges of each model were also addressed in this review.Conclusion:This review encompasses diverse strategies for screening drugs with anti-diarrheal effects and covers a wide range of pathophysiological and molecular mechanisms linked to diarrhea, with a particular emphasis on the challenges of evaluating and predictively validating these experimental models in preclinical studies. This could also help researchers find a new medicine to treat diabetes more effectively and with fewer adverse effects.
Honorifik Bahasa Korea dan Bahasa Indonesia
Authors: Hanani Iva 
Published: November 2022

The aim of this study is to describe the Korean and Indonesian honorifics and compare the honorifics of the two languages. This research is a qualitative research using a contrastive analysis method. Data in the Korean language is collected from the author's private messages with Korean, and data in Indonesian is collected from examples in the referenced literature and substituted with words from the same word class. Based on the analysis that has been carried out, Korean and Indonesian honorifics are both grammatically and lexically realized. However, the grammatical elements that make up Korean honorifics are not limited to one type of sentence, while in Indonesian it is only used in imperative sentences. Vocabularies that contain honorific meanings in Korean are found in adjectives, verbs, and personal pronouns, while in Indonesian mostly are found in personal pronouns and only a few in words from other word classes. From the point of view of Korean honorifics, Indonesian honorifics can be classified into hearer honorifics. In addition, the Indonesian language has subject honorifics, either directly or indirectly, which are lexically realized.
Perancangan Sistem Deteksi Objek Bola dengan Metode Coloring HSV Berbasis VB.Net untuk Robot Sepak Bola Beroda
Authors: Setiyani Atyka , Maison Maison , Fuady Samratul 
Published: November 2022

Metode coloring HSV merupakan cara untuk memfilter warna obyek yang di deteksi dengan warna yang lain berdasarkan lingkup warna hue, saturation, dan value. Metode ini relatif sederhana dengan waktu pemrosesan yang cepat sehingga sangat cocok untuk diterapkan pada robot sepak bola untuk sistem deteksi objek, dalam hal ini adalah deteksi objek bola berwarna orange. Tujuan dari penelitian ini ialah merancang sistem pendeteksi objek bola menggunakan metode coloring HSV dan mengetahui performa sistem dalam mendeteksi objek bola dengan tingkat akurasi deteksi warna orange. Dari penelitian ini didapatkan hasil bahwa sistem yang dibangun dapat mendeteksi objek dengan intensitas cahaya diatas 316 dan jarak objek dibawah 250 cm.
Adamantinoma
Authors: Chahér José , Ebling Hardy , Kac Aron L. , Barbachan J. Jorge , Kilian Egon A. , Quadros Onofre 
Published: November 2022

Estudam-se dez casos de adamantinoma, considerando-se os seguintes fatores: idade, sexo, cor, localização, aspecto radiográfico, duração do tumor, tipo de cirurgia e recidiva. Destaca-se a importância do tipo de cirurgia no problema recidiva dos adamantinomas.
Análisis de la inversión pública en infraestructura en México: caso Refinería Olmeca de Dos Bocas
Authors: Herrera García Adolfo Federico 
Published: November 2022

Problemática: para la economía mexicana, el sector energético es un sector estratégico, el cual en los últimos 20 años ha presentado problemas de ineficiencia en la productividad, lo que ha generado un aumento de la importación de combustibles. Aunado a esto, la crisis sanitaria de la COVID-19 y el conflicto armado de Rusia y Ucrania ha presionado el alza de los valores de los hidrocarburos y sus derivados en el mercado internacional. Objetivo: analizar el caso específico de la inversión pública en infraestructura en el sector energético con la construcción de la nueva refinería de Dos Bocas. Materiales y métodos: para calcular el efecto de la inversión en infraestructura de la Refinería Olmeca de Dos Bocas, se utiliza el modelo de regresión lineal múltiple (MRLM); además, se genera el modelo doble logaritmo para medir la elasticidad de la inversión pública en el aumento económico. Resultados: existe una correspondencia directa entre la inversión en infraestructura física gubernamental en el sector energético y el valor de las gasolinas en México. La liberalización de los valores de la gasolina y el diésel en nuestro país ha generado una dependencia de los valores de los combustibles con el mercado internacional. Discusión: la inversión pública muestra una correspondencia positiva con el aumento económico, pero esto no siempre se cumple, dado que en economías emergentes debe tenerse mucho cuidado con el monto de la inversión pública ejecutado por el gobierno, ya que la probabilidad de que los beneficios de esta se contrarresten es elevado, debido a que el aumento de los impuestos o pagos de endeudamiento interno y externo generan efectos negativos en la economía. Conclusiones: la política de construcción de la refinería conseguirá mejores condiciones en la producción de la gasolina en el mercado nacional, disminuyendo así la importación de combustibles y estimulando la producción de hidrocarburos por parte de la empresa paraestatal PEMEX. Contribución / originalidad: efecto de la inversión en infraestructura de la Refinería Olmeca de Dos Bocas en México.
Racial Disparities in Access and Use of Diabetes Technology Among Adult Patients with Type 1 Diabetes in a U.S. Academic Medical Center
Authors: Kanbour Sarah , Jones Marissa , Abusamaan Mohammed S. , Nass Caitlin , Everett Estelle , Wolf Risa M. , Sidhaye Aniket , Mathioudakis Nestoras 
Published: November 2022

<p> </p>
<p><strong>Objective:</strong> Recent studies highlight racial disparities in insulin pump (PUMP) and continuous glucose monitor (CGM) use in children and adolescents with type 1 diabetes (T1D). This study explored racial disparities in diabetes technology among adult patients with T1D.</p>
<p><strong>Research Design and Methods:</strong> Retrospective clinic-based cohort study of adult patients with T1D seen consecutively from April 2013 to January 2020. Race was categorized into non-Black (reference group) and Black. The primary outcomes were baseline and prevalent technology use, rates of diabetes technology discussions (CGMdiscn, PUMPdiscn), and prescribing (CGMrx, PUMPrx). Multivariable logistic regression analysis evaluated the association of technology discussions and prescribing with race, adjusting for social determinants of health and diabetes outcomes. </p>
<p><strong>Results:</strong> Among 1,528 adults with T1D, baseline technology use was significantly lower for Black compared to non-Black patients (7.9% vs. 30.3% for CGM; 18.7% vs. 49.6% for pump), as was prevalent use (43.6% vs. 72.1% for CGM; 30.7% vs. 64.2% for pump). Black patients had adjusted odds ratios (aORs) of 0.51 (95% CI, 0.29, 0.90) and 0.61 (95% CI, 0.41, 0.93) for CGMdiscn and CGMrx, respectively. Black patients had aORs of 0.74 (95% CI, 0.44, 1.25) and 0.40 (95% CI, 0.22, 0.70), for PUMPdiscn and PUMPrx, respectively. Neighborhood context, insurance, marital and employment status, and number of clinic visits were also associated with the outcomes.</p>
<p><strong>Conclusions and Relevance:</strong> Significant racial disparities were observed in discussions, prescribing, and use of diabetes technology. Further research is needed to identify the causes behind these disparities and develop and evaluate strategies to reduce them.</p>
Mathematical Model of Effect of Yellow Virus on Tomato Plants Through Bemisia tabaci Insects Using Verticillium lecanii Fungus
Authors: Atifah Nada , Murni Dewi , Winanda Rara Sandhy 
Published: November 2022

The Yellow virus is a virus that causes tomato plants to die. The insect vector Bemisia tabaci spreads this virus. The goal of this study is to identify the shape of a mathematical model of the influence of yellow virus on tomato plants via the insect Bemisia tabaci and the fungus Verticilliun lecanii, as well as to interpret the results of the mathematical model analysis. This is referred to as basic research. This study employs a descriptive method in which theories are analysed in relation to the topics to be discussed, and these theories are based on a literature review. Stability analysis is carried out using Routh-Hurwitz criteria. It indicates that the disease-free equilibrium point is asymptotically stable when Λt=μtN and the endemic equilibrium point is asymptotically stable for d1>e1, d2>e2 and a1>(a1)2+(a3)2a0)/(a3a2 ). The model simulation shows that if the efficacy of Verticillium lecanii is high, the population of infected tomato plants, as well as the population of Bemisia tabaci, will go extinct.
Workshop Foto Produk untuk Pengembangan UKM di Kota Padangpanjang
Authors: Muliati Roza 
Published: November 2022

Padangpanjang merupakan kota kecil tempat berkembangnya berbagai Usaha Kecil dan Menengah (UKM) yang menjadi salah satu sektor industri unggulan. Permasalahan yang dihadapi oleh UKM di kota Padangpanjang adalah kurangnya strategi dalam membranding produk ke dalam kemasan visual yang menarik sehingga produk UKM menjadi kurang menarik dan belum dapat menarik dan menjangkau pasar yang lebih luas melalui platform online seperti pemanfaatan media sosial. Tulisan ini menjelaskan workshop foto produk untuk UKM di kota Padangpanjang sebagai solusi dalam mengembangkan pemasaran produk melalui media sosial. Kesadaran akan foto produk yang bagus merupakan upaya untuk mengembangkan daya tarik produk-produk UKM agar bernilai komersil. Dalam pelaksanaannya, kegiatan ini bekerjasama dengan Dinas Koperindag Kota Padangpanjang dan komunitas seni Ruang Tumbuh Padangpanjang. Workshop dilakukan dengan melibatkan delapan UKM dengan luaran berupa keterampilan pelaku UKM dalam membuat foto produk sendiri, mengedit foto produk menggunakan aplikasi, serta mempublikasikannya di media sosial.
Indikator Keuangan dalam Laporan Keuangan dan Kebijakan Dividen
Authors: Tang Sukiantono , Elvin Elvin 
Published: November 2022

This study aims to analyze the relationship between the financial indicators contained in the financial statements and dividend policy. Companies that are listed on the Indonesia Stock Exchange and meet the criteria set out in the study are used as research samples. This study uses 631 observational data from 2017 - 2021 obtained from the company's official website and the Indonesia Stock Exchange. Panel data regression is used to examine the effect of each variable on dividend policy. The best regression model in this study is the Fixed Effect Model. This study shows that free cash flow; firm risk; and return on equity have a significant positive effect on dividend policy. In addition; market to book value ratio and net asset growth have a significant negative effect. Other variables used in this study do not affect dividend policy.
Keywords: Dividend Policy; Profitability; Liquidity; Financial Ratios.
Fraud Hexagon untuk Mendeteksi Indikasi Financial Statement Fraud
Authors: Cipta Adriaan Togudo , Nurbaiti Annisa 
Published: November 2022

This study aims to analyze indications of fraud using the fraud hexagon in property and real estate sector companies listed on the Indonesia Stock Exchange (IDX) in 2016-2020. The research population is 30 companies. The sample selection technique used purposive sampling technique, so that the total sample was 150 observations for the 5-year study period. The study used logistic regression analysis techniques with the help of SPSS version 26 for data processing. The results of the study prove that auditor turnover and political connections have an effect on financial statement fraud, while leverage, effective monitoring (BDOUT), change of directors, and the frequency of appearance of Chief Executive Officer (CEO) photos have no effect on financial statement fraud.
Keywords: Pressure; Opportunity; Rationalization; Ability; Arrogance; Collusion; Fraudulent Financial Statements.