bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mental health issues in parents of children with autism spectrum disorder: A multi‐time‐point study related to COVID‐19 pandemic
Authors: Wang Luxi , Zhang Huiying , Shang Chuang , Liang Huirong , Liu Wenlong , Han Bing , Xia Wei , Zou Mingyang , Sun Caihong 
Published: October 2022

AbstractGiven the unpredictability and challenges brought about by the 2019 novel coronavirus (COVID‐19) pandemic, this study aimed to investigate the impact trend of the prolonged pandemic on the mental health of parents of children with autism spectrum disorder (ASD). The 8112 participants included parents of children with ASD and parents of typically developing (TD) children at two sites (Heilongjiang and Fujian province, China). The parents completed a set of self‐report questionnaires covering demographic characteristics, influences related to COVID‐19, COVID‐19 concerns and perceived behaviors, as well as the Connor‐Davidson resilience scale (CD‐RISC), self‐rating anxiety scale (SAS), and self‐rating depression scale (SDS) by means of an online survey platform. Data were collected by three cross‐sectional surveys carried out in April 2020 (Time 1), October 2020 (Time 2), and October 2021 (Time 3). The results of quantitative and qualitative comparisons showed that: (i) parents of children with ASD had lower levels of resilience, and more symptoms of anxiety and depression than parents of TD children at each time point (all P < 0.05); and (ii) there were significant time‐cumulative changes in resilience, anxiety, and depression among all participants (all P < 0.05). The logistic regression analyzes after adjusting for demographic characteristics revealed that the following factors were significantly associated with poor resilience and a higher rate of anxiety and depression in parents of children with ASD: time‐point, the effect of COVID‐19 on children's emotions and parents' emotions, changes in relationships, changes in physical exercise, changes in daily diet during the COVID‐19 pandemic, and COVID‐19‐related psychological distress. In conclusions, the parents did not report improvements in resilience, anxiety, or depression symptoms from Time 1 to Time 2 or 3, indicating that cumulative mental health issues increased when, surprisingly, the COVID‐19 restrictions were eased. The psychological harm resulting from the COVID‐19 pandemic is far‐reaching, especially among parents of children with ASD.
Physiologically based pharmacokinetic model to predict drug concentrations of breast cancer resistance protein substrates in milk
Authors: Zhang Tao , Zou Peng , Fang Yingsi , Li Yanyan 
Published: October 2022

AbstractMany mothers need to take some medications during breastfeeding, which may carry a risk to breastfed infants. Thus, determining the amount of a drug transferred into breast milk is critical for risk–benefit analysis of breastfeeding. Breast cancer resistance protein (BCRP), an efflux transporter which usually protects the body from environmental and dietary toxins, was reported to be highly expressed in lactating mammary glands. In this study, we developed a mechanistic lactation physiologically based pharmacokinetic (PBPK) modeling approach incorporating BCRP mediated transport kinetics to simulate the concentration–time profiles of five BCRP drug substrates (acyclovir, bupropion, cimetidine, ciprofloxacin, and nitrofurantoin) in nursing women’s plasma and milk. Due to the lack of certain physiological parameters and scaling factors in nursing women, we combine the bottom up and top down PBPK modeling approaches together with literature reported data to optimize and determine a set of parameters that are applicable for all five drugs. The predictive performance of the PBPK models was assessed by comparing predicted pharmacokinetic profiles and the milk‐to‐plasma (M/P) ratio with clinically reported data. The predicted M/P ratios for acyclovir, bupropion, cimetidine, ciprofloxacin, and nitrofurantoin were 2.48, 3.70, 3.55, 1.21, and 5.78, which were all within 1.5‐fold of the observed values. These PBPK models are useful to predict the PK profiles of those five drugs in the milk for different dosing regimens. Furthermore, the approach proposed in this study will be applicable to predict pharmacokinetics of other transporter substrates in the milk.
Rapid screening of α‐glucosidase inhibitors in Hypericum perforatum L. using bio‐affinity chromatography coupled with UPLC/MS
Authors: Dong Qi , Hu Na , Yue Huilan , Wang Honglun , Wei Yue 
Published: October 2022

Abstractα‐glucosidase inhibitors (AGIs) are widely used for the treatment of type 2 diabetes, but their side effects have made it to develop novel and alternative AGIs immediately. In this study, the extract of Hypericum perforatum L. (HPE) has been confirmed to have α‐glucosidase inhibitory activity in vitro and in vivo. Seven active compounds, rutin, hyperoside, isoquercitrin, avicularin, quercitrin, quercetin, and biapigenin, were screened based on a bio‐affinity chromatography column with α‐glucosidase enzyme‐conjugated solid phase and UPLC/MS, which exhibited excellent α‐glycosidase inhibitory effects by the determined IC50 values. The mechanism of α‐glycosidase inhibitory activity of biapigenin was studied for the first time. The results showed that biapigenin was a high‐potential, reversible, and mixed enzyme inhibitor. Analysis by molecular docking further revealed that hydrophobic interactions were generated by interactions between biapigenin and amino acid residues LYS156, PHE303, PHE314, and LEU313. In addition, hydrogen bonding occurred between biapigenin and α‐glucosidase amino acid residues ASP307, SER241, and LYS156. This research identified that biapigenin could be a novel AGI and further applied to the development of potential anti‐diabetic drugs. Furthermore, our studies established a rapid in vitro screening method for AGIs from plants.
Genomic characterization reveals distinct mutation landscapes and therapeutic implications in neuroendocrine carcinomas of the gastrointestinal tract
Authors: Wu Huanwen , Yu Zicheng , Liu Yueping , Guo Lei , Teng Lianghong , Guo Lingchuan , Liang Li , Wang Jing , Gao Jie , Li Ruiyu , Yang Ling , Nie Xiu , Su Dan , Liang Zhiyong 
Published: October 2022

AbstractBackgroundNeuroendocrine carcinomas of the gastrointestinal tract (GI‐NECs) remain a disease of grim prognosis with limited therapeutic options. Their molecular characteristics are still undefined. This study aimed to explore the underlying genetic basis and heterogeneity of GI‐NECs.MethodsComprehensive genomic analysis using whole‐exome sequencing was performed on 143 formalin‐fixed, paraffin‐embedded samples of surgically resected GI‐NEC with a thorough histological evaluation. Mutational signatures, somatic mutations, and copy number aberrations were analyzed and compared across anatomic locations and histological subtypes. Survival analysis was conducted to identify the independent factors.ResultsIn total, 143 GI‐NECs were examined: the stomach, 87 cases (60.8%); the esophagus, 29 cases (20.3%); the colorectum, 20 cases (14.0%); and the small intestine, 7 cases (4.9%). Eighty‐three (58.0%) and 60 (42.0%) cases were subclassified into small cell and large cell subtypes, respectively. GI‐NECs showed distinct genetic alterations from their lung counterparts and non‐neuroendocrine carcinomas in the same locations. Obvious heterogeneity of mutational signatures, somatic mutations, and copy number variations was revealed across anatomic locations rather than histological subtypes. Except for tumor protein p53 (TP53) and retinoblastoma 1 (RB1), the most frequently mutated genes in the stomach, esophagus, colorectum, and small intestine were low‐density lipoprotein receptor‐related protein 1B (LRP1B), notch receptor 1 (NOTCH1), adenomatosis polyposis coli (APC), catenin beta 1 (CTNNB1), respectively. Mutations in the WNT‐β‐catenin, NOTCH and erythroblastic leukemia viral oncogene B (ERBB) pathways were prevalently identified in gastric, esophageal, and colorectal NECs, respectively. Importantly, 104 (72.7%) GI‐NECs harbored putative clinically relevant alterations, and non‐gastric location andRB1bi‐allelic inactivation with copy number alterations were identified as two independent poor prognostic factors. Furthermore, we found that tumor cells in GI‐NECs first gain clonal mutations inTP53,RB1,NOTCH1andAPC, followed by subsequent whole‐genome doubling (WGD) and post‐WGD clonal mutations inLRP1B, CUB and Sushi multiple domains 3 (CSMD3), FAT tumor suppressor homolog 4 (FAT4) and erb‐b2 receptor tyrosine kinase 4 (ERBB4), and finally develop subclonal mutations.ConclusionsGI‐NECs harbor distinct genomic landscapes and demonstrate significant genetic heterogeneity across different anatomic locations. Moreover, potentially actionable alterations and prognostic factors were revealed for GI‐NECs.
“Okokuqala ngokuya ndandiqala kwakungekho easy”: Feeling empowered to take collective action through community engagement
Authors: Bobo Benita , Akhurst Jacqueline 
Published: October 2022

AbstractCommunity engagement (CE) at Rhodes University (RU) and community psychology draw on similar principles: using an asset‐based community development approach; recognising and drawing on the skills, capabilities, and knowledge of all parties, which they contribute to a partnership. Working from a strategic model of engagement, mutuality is foreground in all CE activities, where both student volunteers and community partners jointly benefit from the engagement. This paper examines CE at RU and how CE principles are translated into practise, using Siyakhana@Makana (S@M) as a case study. In S@M, a 19‐week‐long volunteer programme, community partners and student volunteers are jointly involved in planning, executing, and evaluating CE activities together. This paper illustrates how being involved in such CE activities has enabled community partners to mobilise for effective change in their communities. Community partners reflect on how they have been empowered to taken on leadership roles, addressing local challenges in collaborative ways, while drawing on the skills and knowledge that they have gained through their engagements in S@M. This resonates with the social action model of community psychology, a participatory approach that seeks to mobilise people to bring about change in the contexts in which they live.
Designing, Synthesis, and Anti‐Breast Cancer Activity of a Series of New Quinazolin‐4(1H)‐one Derivatives
Authors: Madhava Reddy Manne , Desikan Rajagopal , Naik Sanjay , Kumar Sanjit , Kumar D Thirumal , Priya Doss C George , Sivaramakrishna Akella 
Published: October 2022

AbstractThe inhibition of phosphatidylinositol‐4,5‐bisphosphate 3‐kinase catalytic subunit alpha (PIK3CA) protein could be a promising treatment for breast cancer. In this regard, docking studies were accomplished on various functionalized organic molecules. Among them, several derivatives of quinazolin‐4(1H)‐one exhibited anti‐breast cancer activity and satisfied the drug likeliness properties. Further, thein vitroinhibitory studies by a series of 2‐(2‐phenoxyquinolin‐3‐yl)‐2,3‐dihydroquinazolin‐4(1H)‐one molecules showed strong anti‐cancer activity than the currently available drug, wortmannin. The MTT cytotoxicity assay was used to predict the anti‐proliferative activity of these drugs against MCF‐7 cancer cells by inhibiting the PIK3CA protein. The dose‐dependent analysis showed a striking decrease in cancer cell viability at 24 h with inhibitory concentrations (IC50) of3b,3c,3d,3fand3mare 15±1, 17±1, 8±1, 10±1 and 60±1 (nanomoles), respectively. This is the first report in the literature on the inhibition of PIK3CA protein by quinazolinone derivatives that can be used in the treatment of cancer. Quinazolinone analogs have the potential to be safe and economically feasible scaffolds if they are produced using a chemical technique that is both straightforward and amenable to modification. From the cancer research perspective, this study can eventually offer better care for cancer patients.
Combined rotational atherectomy and cutting balloon angioplasty prior to drug‐eluting stent implantation in severely calcified coronary lesions: The PREPARE‐CALC‐COMBO study
Authors: Allali Abdelhakim , Toelg Ralph , Abdel‐Wahab Mohamed , Hemetsberger Rayyan , Kastrati Adnan , Mankerious Nader , Traboulsi Hussein , Elbasha Karim , Rheude Tobias , Landt Martin , Geist Volker , Richardt Gert 
Published: October 2022

AbstractObjectivesTo evaluate the safety and efficacy of lesion preparation using rotational atherectomy (RA) with consecutive cutting balloon angioplasty (Rota‐Cut).BackgroundWhether the Rota‐Cut combination improves stent performance in severely calcified coronary lesions is unknown.MethodsPREPARE‐CALC‐COMBO is a single‐arm prospective trial in which 110 patients were treated with a Rota‐Cut strategy before implantation of sirolimus‐eluting stents and compared with patients treated with modified balloon (MB, scoring or cutting) or RA from a historical cohort (the randomized PREPARE‐CALC trial). The study had two primary endpoints: in‐stent acute lumen gain (ALG) by quantitative angiographic analysis and stent expansion (SE) on optical coherence tomography.ResultsIn‐stent ALG was significantly higher with Rota‐Cut compared to RA or MB alone (1.92 ± 0.45 mm vs. 1.74 ± 0.45 mm with MB vs. 1.70 ± 0.42 mm with RA; p = 0.001 and p < 0.001, respectively). SE was comparable between groups (75.1 ± 13.8% vs. 73.5 ± 13.3 with MB vs. 73.1 ± 12.2 with RA; p = 0.19 and p = 0.39, respectively). The Rota‐Cut combination resulted in higher minimal stent area (MSA) (7.1 ± 2.2mm2 vs. 6.1 ± 1.7mm2 with MB vs. 6.2 ± 1.9mm2 with RA; p = 0.003 and p = 0.004, respectively). In‐hospital death occurred in one patient. Target vessel failure at 9 months was low and comparable between groups (8.2% vs. 8% with MB vs. 6% with RA; p = 1 and p = 0.79, respectively).ConclusionRota‐Cut combination resulted in higher ALG and larger MSA compared with historical control of RA or MB alone, but was not associated with higher SE. Despite extensive lesion preparation, this strategy is safe, feasible, and associated with favorable clinical outcome at 9 months.
COVID‐19‐related rhino‐orbital‐cerebral mucormycosis: Neurological manifestation and related risk factors in two cases
Authors: Ohadi Mohammad Amin Dabbagh , Banihashemi Gelareh , Dilmaghani Nader Akbari , Shamsi Mohammad Ali , Sharifi Guive 
Published: October 2022

AbstractMucormycosis is an opportunistic infection that has become a serious concern as a result of the immunosuppressive drugs used during COVID‐19. In this report, we describe two cases of rhino‐orbital‐cerebral mucormycosis with neurological presentation and ophthalmologic problems accompanied by a history of COVID‐19 and diabetes.
Efficacy of intraoperative fluorescence imaging using indocyanine green‐containing gauze in identifying the appropriate dissection layer in laparoscopic intersphincteric resection: A case report
Authors: Kumata Hiroyuki , Onishi Keisuke , Takayama Tetsuro , Asami Kengo , Obara Noriyuki , Sugawara Hirofumi , Haga Izumi 
Published: October 2022

AbstractIn laparoscopic intersphincteric resection, identifying the dissection layer near the anus is often difficult. We safely proceeded with it, using indocyanine green‐containing gauze on the anal side to remove the internal anal sphincter with indocyanine green fluorography.
Temperature Distribution in Fluidized Beds of Porous Particles with Liquid Injection
Authors: Milacic Evan , Rantong Dylan R. , Kuipers J. A. M. , Baltussen Maike. W. 
Published: October 2022

AbstractLiquid injection in fluidized beds is used to add reactants or to improve the heat management in the reactor. This injection will increase the complexity of reactor due to the formation of agglomerates. In this work the effect of the injection on the particle temperature distribution in a fluidized bed of porous particles is determined experimentally using particle image velocimetry and infra‐red thermography. The main property of the porous particles influencing the distribution is the specific surface area. In addition, the porosity has a large effect on the defluidization of the fluidized bed.
The Utilization and Modeling of Photo‐Fenton Process as a Single Unit in Textile Wastewater Treatment
Authors: Sarı Bülent , Türkeş Selman , Güney Hakan , Keskinkan Olcayto 
Published: October 2022

AbstractStudies on the direct application of the photo‐Fenton process (PFOP) to disinfect and decontaminate textile wastewater are rare. The output of the artificial neural network (ANN) models applied to the wastewater of a textile factory producing woven fabrics, which is used to assess the efficiency of the PFOP process, are investigated and compared with each other in this study. The highest PFOP efficiency is obtained at a pH of 3. Chemical oxygen demand (COD), suspended solids (SS) and color removal rates are 94%, 90%, and 96%, respectively. The data are modeled with ANNs and nonlinear external input autoregressive ANNs (NARX‐ANN) using the MATLAB R2020a software program. Both Levenberg–Marquardt (trainlm) and scaled conjugate gradient (trainscg) algorithms are employed in the ANN and NARX‐ANN models, whereas hyperbolic tangent sigmoid (Tansig) and logistic sigmoid (Logsig) functions are superimposed on the hidden layer in the ANN model, and Tansig functions are superimposed on the NARX‐ANN model. It is determined that the developed ANN models are more effective in estimating the PFOP efficiency. The mean squared error is 0.000 953, and the coefficient of determination (R2) is 0.96 661.
Fine‐Tuning the Photophysics of Donor‐Acceptor (D‐A3) Thermally Activated Delayed Fluorescence Emitters Using Isomerisation
Authors: L. dos Santos Paloma , de Sa Pereira Daniel , Eng Julien , Ward Jonathan S. , Bryce Martin R. , Penfold Thomas J. , Monkman Andrew P. 
Published: October 2022

AbstractHere two D–A3 regioisomers, comprising three dibenzothiophene‐S,S‐dioxide acceptor units attached to a central triazatruxene core, are studied. Both molecules show thermally activated delayed fluorescence (TADF), however, the efficiency of the TADF mechanism is strongly affected by the D–A substitution position. The meta‐ substituted emitter (1 b) shows a slightly higher‐lying singlet charge transfer state and a lower‐lying triplet state than that observed in the para‐ substituted emitter (1 a), resulting in a larger singlet–triplet splitting (ΔEST) of 0.28 eV compared to only 0.01 eV found in 1 a. As expected, this ΔEST difference strongly impacts the reverse intersystem crossing (rISC) rates and the para‐ isomer 1 a exhibits a much faster delayed fluorescence emission. Calculations show that the triplet energy difference between the two isomers is due to steric hindrance variances along the donor–acceptor rotation axis in these molecules: as 1 b is less restricted, rotation of its acceptor unit leads to a lower T1 energy, further away from the region of high density of states (the region where larger vibronic coupling is found, favouring rISC). Therefore, our results show how the substitution pattern has a marked effect on triplet state energies and character, verifying the key structural designs for highly efficient TADF materials.
Corporate governance and environmental sustainability: Addressing the dual theme from a bibliometric approach
Authors: Enciso‐Alfaro Saudi‐Yulieth , García‐Sánchez Isabel‐María 
Published: October 2022

AbstractEnvironmental sustainability represents a business challenge that draws the attention of multidisciplinary and multicultural researchers. This study presents a comprehensive picture of the most relevant research on corporate governance and environmental sustainability since 1991. Through a bibliometric analysis of 233 articles retrieved from the Scopus database, we find that 71.67% of the research that addresses the dual theme in the last 7 years appears in journals of recognized impact (e.g., Business Strategy and the Environment). Researchers in the field focus on the United States, the United Kingdom, and China; determined by total link strength, D. M. Patten, D. Cormier, and P. Berrone are the most influential authors. We also identify 11 thematic groups or subdomains notable for their size and/or validity, including green innovation, institutional factors, climate change, environmental impact, and the board. Remaining to be addressed in future research are the agrifood sector, investment and energy efficiency, and patents and invention. In addition, theoretical approaches should be incorporated with cultural nuances that enrich our understanding of corporate governance as a driving mechanism of climate change.
A comprehensive review on the history, uses, and safety of onabotulinum toxin type A (Botox)
Authors: Patel Kevin R. , Rastogi Supriya , Prather Heidi B. 
Published: October 2022

AbstractOnabotulinumtoxinA (ONA), trademarked under the brand name Botox, is a widely studied botulinum neurotoxin currently used for diverse cosmetic and noncosmetic therapeutic treatments. ONA was the first in a growing market of injectable neuromodulators to be studied for medical use. First introduced to the cosmetic marketplace in 2002 by the U.S. Food and Drug Administration for clinical indication of wrinkle correction for glabellar frown lines, ONA has proven to be an invaluable tool in the armamentarium of aesthetic medicine. The most commonly approved dermatologic uses of ONA include facial rhytidosis and hyperhidrosis with ongoing phase 2B studies for masseter hypertrophy. Nondermatologic applications include temporomandibular disorders, strabismus, cervical dystonia, blepharospasm, spasticity, migraines, overactive bladder, and incontinence. Off‐label uses of ONA are well studied in skin disorders, such as rosacea, and other indications, such as Frey's syndrome, and depression. Further, multiple studies have illustrated an improvement in quality of life and self‐esteem with ONA treatment. The favorable side effect profile with minimal adverse effects reinforces that ONA is a safe and effective treatment option with a diverse portfolio of clinically accepted applications.
Fracture distribution in overburden strata induced by underground mining
Authors: Yao Wenli , Wang Enzhi , Liu Xiaoli , Zhou Ran 
Published: October 2022

AbstractCoal‐mining activities give rise to a series of ecological environmental problems, such as ground settlement and groundwater pollution. In fact, they are mainly caused by mining‐induced fractures. Hence, it is necessary to study the mining‐induced fracture distribution to identify the behavior of rock mass movement. However, the fractures in overburden strata cannot be directly measured owing to the special condition. Therefore, the majority of previous studies are based on experiments or experience. For this reason, this study first used a discrete element method to simulate the shape of mining‐induced fractures in overburden strata. Then, a geophysical tool of transient electromagnetic method (TEM) was used to investigate the mining‐induced fracture distribution. Based on the low‐resistivity anomaly area, the water‐rich area in overburden strata was analyzed to be mainly caused by fracture seepage. Through the mutual authentication between numerical simulation and TEM results, the mining‐induced fractures in overburden strata were explored. This study can enhance the understanding of mining‐induced fracture distribution on the one hand and guarantee the coal mining safety on the other, thus guiding the coordinated development between coal mining and environmental protection.