bluuebunny/crossref_metadata_2025_split huggingface dataset:
Four common vitamin D receptor polymorphisms and coronary artery disease susceptibility: A trial sequential analysis
Authors: Yan Xiaofei , Wei Yuzhen , Wang Dan , Zhao Jiangtao , Zhu Kui , Liu Yuan , Tao Hailong 
Published: October 2022

BackgroundStudies on the susceptibility of vitamin D receptor (VDR) polymorphisms to coronary artery disease (CAD) reached controversial results. We performed this study for a more accurate evaluation between the VDR polymorphisms and CAD susceptibility.MethodsPubMed, Embase, CNKI, Wan Fang, and VIP databases were searched. The odds ratios (ORs) and 95% confidence intervals (95% CIs) were used to evaluate the associations. Trial sequential analysis (TSA) was introduced to estimate the positive associations. The potential functions of the VDR polymorphisms were analyzed based on the SNPinfo and ENSEMBL databases.ResultsThirteen studies were finally included. In the overall analysis, increased CAD risks were observed in the VDR rs1544410 polymorphism and verified by the TSA; for the rs2228570 and rs731236 polymorphisms, significant associations with high heterogeneity were detected; decreased risk was remarkably observed for the rs7975232 polymorphism. In the subgroup analysis, wide associations with reduced heterogeneity were observed in the rs2228570, rs1544410, and rs731236 polymorphisms. The RNAfold analysis indicated the mutant G allele of the rs1544410 polymorphism was easier to disperse from the DNA double helix structure and may have a potential crucial role in the VDR transcription process.ConclusionsOur analysis supports the role of the rs1544410 polymorphism in the VDR gene as a risk factor for CAD. The VDR rs2228570 and rs731236 polymorphisms were associated with increased CAD risks in the White population. Restrict decreased CAD risk was firstly discovered in the rs7975232 polymorphism.LimitationsFirstly, the language was restricted to English and Chinese, which will cause the limited number of studies included; secondly, other unknown polymorphisms in VDR polymorphisms could also be associated the CAD susceptibility, and more case-control studies with comprehensive clinical outcomes and GWAS studies were required; thirdly, the rs1544410, rs7975232 and rs731236 polymorphism are in strong LD, haploid factors with CAD risk need to be considered; fourthly, the mechanisms of the VDR polymorphism on the VDR gene or RNA or protein were not discussed enough, further mechanistic studies are required; at last, genetic factor was the one side for CAD susceptibility, the interaction between environmental risk factors should be considered.
Fecal Calprotectin and Quality of Life Questionnaires Are Responsive to Change in Pouch Disease Activity After Antibiotic Therapy: Results From a Prospective Clinical Trial
Authors: Ollech Jacob E. , Yanai Henit , Avni-Biron Irit , Snir Yifat , Banai Hagar , Barkan Revital , Godny Lihi , Wasserberg Nir , White Ian , Dotan Iris 
Published: October 2022

INTRODUCTION:
Whether fecal calprotectin (FC) and quality of life (QoL) questionnaires reflect change in disease activity in patients with a J-pouch is unknown.

METHODS:
Patients with acute pouchitis were prospectively treated with a 2-week course of antibiotics. The full Pouchitis Disease Activity Index, FC, and QoL questionnaires were measured at baseline and after antibiotic therapy.

RESULTS:
Twenty patients were prospectively enrolled. After 2 weeks of antibiotic treatment, the Pouchitis Disease Activity Index decreased from a median of 9 to 5 (P = 0.007). FC decreased from a median of 661 ug/g to 294 ug/g (P = 0.02), and QoL questionnaires improved significantly.

DISCUSSION:
FC and QoL questionnaires reflect real-time changes in inflammatory pouch activity.
Sobolev-Gaffney type inequalities for differential forms on sub-Riemannian contact manifolds with bounded geometry
Authors: Baldi Annalisa , Tesi Maria Carla , Tripaldi Francesca 
Published: October 2022

Abstract
In this article, we establish a Gaffney type inequality, in

W

ℓ
,
p

{W}^{\ell ,p}

-Sobolev spaces, for differential forms on sub-Riemannian contact manifolds without boundary, having bounded geometry (hence, in particular, we have in mind noncompact manifolds). Here,

p
∈

]

1
,
∞

[

p\in ]1,\infty {[}

and

ℓ
=
1
,
2

\ell =1,2

depending on the order of the differential form we are considering. The proof relies on the structure of the Rumin’s complex of differential forms in contact manifolds, on a Sobolev-Gaffney inequality proved by Baldi-Franchi in the setting of the Heisenberg groups and on some geometric properties that can be proved for sub-Riemannian contact manifolds with bounded geometry.
Novel quotes: Achilles Tatius and Heliodorus in Byzantine sacro-profane florilegia
Authors: D’Alconzo Nicolò 
Published: October 2022

Abstract
The quotes in the sacro-profane florilegia have so far been neglected as documents for the 9th-century readership of the Greek novels. This article uses the quotes as intertextual links to the originals and reconstructs the excerption: mapped back onto the novels, the quotes highlight the excerptors’ points of interest and the patterns that connect them. Excerption is thus fully understood as reading practice. The quotes were collected not only because they could provide wisdom when decontextualised, but also because they played a relevant role in the excerptors’ analysis and interpretation of the novels. The florilegia are therefore unique texts in revealing the experience of reading the novels in the 9thcentury.
Further useful Psalms
Authors: Zellmann-Rohrer Michael 
Published: October 2022

Abstract
An additional witness to the Byzantine tradition of application of Psalms for amuletic and other ritual purposes, conventionally termed “magical”, in a fifteenth-century codex on medicine and the occult sciences (Bologna, BU Ms. 3632), is edited and translated, and its place in the tradition is considered. Combined with another, indirect witness, references to analogous uses of the Psalms by Theodore Balsamon and Matthew Blastares, this evidence strengthens a recent suggestion of broad popularity for the practice in Byzantium.
Modeling spa destination choice for leveraging hydrogeothermal potentials in Serbia
Authors: Radin Marija Belij , Vujičić Miroslav D. , Todorović Nikola , Dragin Aleksandra S. , Stankov Uglješa , Mijatov Maja B. 
Published: October 2022

Abstract
Serbian spas, with their abundant geothermal springs and air qualities, are a significant natural resource for the country. Nowadays, tourism industry has become a predominant beneficiary attracting both leisure- and health-related visits. Nonetheless, the literature on current consumer behavior is devoid of a model that incorporates both motivating and constraining factors in the spa and wellness industry’s decision-making process. Serbia’s spa industry is still adjusting to the needs of the modern wellness visitor as a result of the country’s unique transitional path. The purpose of this study is to ascertain the role of incentive and restrictions in the destination selection process of spa visitors in Serbia, to gain insight into the development of wellness tourism in a particular sociocultural environment. The analytical hierarchy process was used to determine the relative relevance of the consumer behavior elements evaluated. The findings indicate that non-medical motivations are becoming more important, implying that demand is finally shifting toward the wellness idea, which was initially disrupted by the country’s delayed transformation. The findings have administrative ramifications, the most significant of which were price strategies and product diversification.
lncRNA FAM230B is highly expressed in colorectal cancer and suppresses the maturation of miR-1182 to increase cell proliferation
Authors: Li Ni , Zhou Chuane , Yang Fan 
Published: October 2022

Abstract
Long non-coding RNA FAM230B and microRNA (miR-1182) have been characterized as critical players in cancer biology, while their roles in colorectal cancer (CRC) are unclear. We predicted that they could interact with each other and therefore explored the interaction between them in CRC. CRC and paired non-tumor tissue samples were collected from 60 CRC patients, and the expression of FAM230B and miR-1182 (premature and mature) in these samples was analyzed with RT-qPCR. The direct interaction between FAM230B and premature miR-1182 was analyzed with RNA-RNA pull-down assay, and the subcellular location of FAM230B was detected with subcellular fractionation assay. The interaction between FAM230B and miR-1182 was explored with overexpression assay, and their roles in regulating CRC cell proliferation, viability, and colony formation were assessed by BrdU assay, MTT assay, and colony formation assay, respectively. We found that FAM230B and premature miR-1182 were highly upregulated in CRC, while mature miR-1182 was downregulated in CRC. FAM230B was detected in both nucleus and cytoplasm, and it directly interacted with miR-1182. FAM230B overexpression increased the expression levels of premature miR-1182 but decreased the expression levels of mature miR-1182 in CRC cells. FAM230B promoted CRC cell proliferation, increased cell viability, accelerated colony formation, and suppressed the role of miR-1182 in inhibiting CRC cell proliferation. In conclusion, FAM230B is upregulated in CRC and it suppresses the maturation of miR-1182 to promote tumor growth.
Brucellatransmission from domestic and wild animals to dromedary camel: Diagnostic methods and zoonotic threats – A review
Authors: Adel Mammeri 
Published: October 2022

AbstractThe present review discusses the transmission risk factors of camel (Camelus dromedarius) brucellosis in the limits of domestic and wild interfaces and zoonotic threats. The median position of the dromedary’s life between wild and the domestic areas seems to increase the risks of brucellosis transmission, compared to other receptive domestic ruminants. In arid environments, canids, lagomorphs, rodents, and wild boars are potential reservoirs ofBrucellaspp. Dromedary camels raised according to a periurban breeding system are often in direct or indirect contact with wild animals, domestic animals, and humans. Constraints of brucellosis detection and control in wild animals, especially in developing countries, hamper preventing disease in camelids and related occupational categories. A total eradication of animal and human brucellosis, in developing countries, is faced by the difficulty of applying quarantine periods for suspected animals, the lack of reliable diagnostic tools, and the impossibility of controlling animals at the common grazing lands, livestock markets, and transboundary areas. In developing countries, the informal she-camel milk collection, the periurban camel breeding, and the shortage in the technological processing and the pasteurization of she-camel milk play a key role in brucellosis zoonotic transmission.Veterinarians should have more initiative in brucellosis control in both domestic and wildlife animals.
The Eastern Mediterranean Energy Bonanza: A Piece in the Regional and Global Geopolitical Puzzle, and the Role of the European Union
Authors: Badarin Emile , Schumacher Tobias 
Published: October 2022

Abstract
This article examines current energy-related disputes in the Eastern Mediterranean. It does so by situating them in the context of the Middle East’s broader geopolitical landscape and by showing how global powers’ interests and involvement have become contingent on the international and regional political environments. The latter augmented the intensity of the contestation and helped move identifiable and tangible factors, such as Exclusive Economic Zones, into the imaginative realms of geopolitics. They also provided the concerned actors with opportunities to balance out their adversaries and, by implication, diminished their willingness to compromise. Although the global powers’ interest in Eastern Mediterranean energy resources is limited, the European Union does have interests in these reserves and related aspects. The fact that the monetisation of these resources is highly dependent on the EU market provides the EU with an immense amount of “buyer power” to stabilise the region and potentially balance the fears of both Greece and Turkey.
Big (Crisis) Data in Refugee and Migration Studies – Case Study of Ukrainian Refugees
Authors: Jurić Tado 
Published: October 2022

Abstract
This paper presents a review of Big Data sources that could be helpful in determining, estimating, and forecasting the forced emigration flows of refugees from Ukraine. The text shows how a Big Data approach can help assess refugees’ intentions. Using insights from social-media platforms such as Facebook, Instagram, and YouTube is useful, because data here are available faster than any official data in the refugee crisis triggered by the Russian attack on Ukraine on 24 February 2022.
Emx1-Cre Is Expressed in Peripheral Autonomic Ganglia That Regulate Central Cardiorespiratory Functions
Authors: Ning Yao , Noebels Jeffrey L. , Aiba Isamu 
Published: October 2022

AbstractThe Emx1-IRES-Cre transgenic mouse is commonly used to direct genetic recombination in forebrain excitatory neurons. However, the original study reported that Emx1-Cre is also expressed embryonically in peripheral autonomic ganglia, which could potentially affect the interpretation of targeted circuitry contributing to systemic phenotypes. Here, we report that Emx1-Cre is expressed in the afferent vagus nerve system involved in autonomic cardiorespiratory regulatory pathways. Our imaging studies revealed expression of Emx1-Cre driven tdtomato fluorescence in the afferent vagus nerve innervating the dorsal medulla of brainstem, cell bodies in the nodose ganglion, and their potential target structures at the carotid bifurcation such as the carotid sinus and the superior cervical ganglion (SCG). Photostimulation of the afferent terminals in the nucleus tractus solitarius (NTS)in vitrousing Emx1-Cre driven ChR2 reliably evoked EPSCs in the postsynaptic neurons with electrophysiological characteristics consistent with the vagus afferent nerves. In addition, optogenetic stimulation targeting the Emx1-Cre expressing structures identified in this study, such as vagus nerve, carotid bifurcation, and the dorsal medulla surface transiently depressed cardiorespiratory rate in urethane anesthetized micein vivo. Together, our study demonstrates that Emx1-IRES-Cre is expressed in the key peripheral autonomic nerve system and can modulate cardiorespiratory function independently of forebrain expression. These results raise caution when interpreting systemic phenotypes of Emx1-IRES-Cre conditional recombinant mice, and also suggest the utility of this line to investigate modulators of the afferent vagal system.
Location‐atypical lesions in non‐ketotic hyperglycemic epilepsy: expanding the clinico‐radiographic phenotype
Authors: Amar Jordan Y. , Bhattacharya Anup K. , Uzo‐Okereke Adaku M. , Chou Chris A. , Vo Katie D. , Goyal Manu S. , Bucelli Robert C. 
Published: October 2022

AbstractNon‐ketotic hyperglycemia (NKH) is associated with a spectrum of symptoms and radiographic findings due to poorly‐controlled diabetes mellitus. These lesions, which predominantly affect the parieto‐occipital cortex, are commonly missed by neurologists and neuroradiologists due to their subtle hypointense appearance on T2‐based imaging. We report four atypical cases of this syndrome to highlight its subtle, protean presentation in order to aid timely diagnosis. Based on our institutional case series, we describe four cases of NKH with atypical presentation and lesion burden affecting the anterior cortex. We review the clinical presentations, laboratory abnormalities, neuroimaging, and corresponding electroencephalography. Four patients with atypical NKH were characterized in our series. Presenting symptoms ranged from rhythmic handtapping to generalized tonic‐clonic status epilepticus. Laboratory values were notable for marked hyperglycemia (range: 447 – 627 mg/dL), mild pseudohyponatremia (range: 127 – 136 mmol/L), and elevated hemoglobin A1C levels (range: 10.9 16.1%). All patients were found to have the classically described pattern of T2‐based hypointensity; three with atypical distributions involving the “anterior” cortex. These lesions corresponded to the electrographic nidus of seizure burden. During follow‐up, both seizures and T2‐based hypointensity resolved within weeks of serum glucose normalization. Our series of four NKH patients with atypical findings of T2‐based signal abnormalities expands the clinico‐radiographic phenotype revealing a more protean distribution than previously described. Knowledge of these atypical imaging features will aid both the neurologist and radiologist in timely diagnosis and care of these patients.
Klasik Elit Teorisyenlerinde Makyavelist İzler
Authors: YALÇIN Muhammed Akif 
Published: October 2022

Bu çalışmanın amacı Siyaset sosyolojisi disiplini içerisinde ele alınan elit teorileri ve seçkinci yaklaşımların klasik temsilcileri olan Pareto, Mosca ve Michels’in yaklaşımlarına İtalyan düşünür Machiavelli’nin etkisini incelemektir. Siyasal açıdan yönetim biçimlerini şekillendiren, çoğunluk-azınlık ilişkileri, güçlü ve etkili olanın yönetimde sahip olduğu pay, iktidarın toplumsal kabulünü sağlayan nedenler ve bu nedenlerin meşrulaştırılması elit teorilerinin kapsamına girmektedir. Elit teorisyenlerinin üzerinde durduğu bazı kavramlar Machiavelli’nin öğretilerinde ileri sürdüğü temel kavramlarla ilişkilidir. Bu kavramlar ve kullanıldığı bağlamlar güçlü olmaya, kurnaz olmaya ve sahip olunan statünün korunmasına vb. ilişkindir. Makyavelist tutum ve yöntemlerin elit teorilerinin oluşumundaki etkilerinin incelenmesinin, klasik elit yaklaşımlarının farklı bir perspektiften irdelenmesine imkân vereceği düşünülmektedir.
Sosyolojik bir kavram olarak irdelenen “eşitsizlik” ve buna bağlı olarak temellenen “tabakalaşma” kavramının siyasal alandaki izdüşümünün elit teorilerinin yardımıyla incelenmesi hem sosyoloji hem de siyasal bilimler açısından önemlidir. Zira seçkin-elit yaklaşımların arka planındaki Makyavelist felsefe siyasal tabakalaşmanın sistematiğini ana hatlarını aydınlatmaktadır.
Bu çalışmada birincil ve ikincil kaynakların incelendiği ve düşünürlerin görüşlerinin karşılaştırmalı olarak sunulduğu bir yöntem benimsenmiştir. Dolayısıyla öncelikle Machiavelli’nin eserlerinde ileri sürdüğü görüşlerinden hareket edilerek teorik arka plana dair bilgi verilmiştir. Ardından yukarıda isimleri geçen düşünürlerin elit teorilerine yaptıkları katkıları karşılaştırmalı olarak ele alınmıştır.
Numerical Simulation and Assessment of Meta Heuristic Optimization Based Multi Objective Dynamic Job Shop Scheduling System
Authors: Rajput Bhumika Singh , Gangele Anshul , Alaria Satish Kumar 
Published: October 2022

In today's world of manufacturing, cost reduction becomes one of the most important issues. A successful business needs to reduce its cost to be competitive. The programming of the machine is playing an important role in production planning and control as a tool to help manufacturers reduce their costs maximizing the use of their resources. The programming problem is not only limited to the programming of the machine, but also covers many other areas such such as computer and information technology and communication. From the definition, programming is an art that involves allocating, planning the allocation and utilization of resources to achieve a goal. The aim of the program is complete tasks in a reasonable amount of time. This reasonableness is a performance measure of how well the resources are allocated to tasks. Time or time-dependent functions are always it used as performance measures. The objectives of this research are to develop Intelligent Search Heuristic algorithms (ISHA) for equal and variable size sub lot for m machine flow shop problems, to Implement Particle Swarm Optimization algorithm (PSO) in matlab, to develop PSO based Optimization program for efficient job shop scheduling problem. The work also address solution to observe and verify results of PSO based Job Shop Scheduling with help of graft chart.
Economic Theories and Models: a Contribution in Understanding Their Foundations
Authors: Emmanuel NDINGA GO’O 
Published: October 2022

The interest of discovering and unveiling the thoughts of great scholars, condensed in theories comes at the right time in order to understand the knowledge revealed during studies of social sciences, in particular economics. The main intention of this article is to make understand the ideas that led these authors to state them, taking into account the temporal spatial conditions of the corresponding eras. This led to the emergence of these ideologies. Which over time have been considered as framework laws of a constitution, or even more gospel words to follow and not to break.
The answer to the question posed in the background, namely can we easily affirm that the theories and models designed by these authors are founded on the basis of facts and phenomena observed in their time? In other words: do these theories have a link with their times? Bring us to adopt a comparative analysis which allowed us to note that most of the results or constructions of models married the living ideology at that time. That the classics, for example, could only build models with reference to the functioning of their time, or that the Keynesians could only develop theories that matched the image of the facts observed at that time.
Understanding this constructive process of theories and economic models will allow us, my liver, at the end of this look, to understand the reasons which animated the founders of these theories to state them. Better still, we will be able to envisage future visions and ideological thoughts of future generations, in view of the evolution of human behavior observed today.
Efficacy of Platelet-Rich Plasma in Soft Tissue Foot and Ankle Pathology
Authors: Johnson Lindsey G. , Buck Erin H. , Anastasio Albert T. , Abar Bijan , Fletcher Amanda N. , Adams Samuel B. 
Published: October 2022

» The preparation methodology for platelet-rich plasma (PRP) may have important clinical implications with varying effectiveness with leukocyte, platelet, and growth factor concentrations.» There is high-quality evidence to support the superiority of PRP over corticosteroids in the case of chronic plantar fasciitis.» There is moderate-quality to high-quality evidence for PRP's ability to increase tendon thickness with no capacity to decrease pain, increase function, or augment percutaneous tenotomy in Achilles tendinopathy.» There is insufficient evidence to support PRP injections in the definitive treatment of Achilles tendon rupture. However, PRP may contribute to postoperative recovery after tendon rupture repair, but this requires further research.» The biochemical theory supporting the clinical use of PRP must be reinforced with high-level evidence research. Based on the current literature, PRP may serve as a viable treatment method in chronic plantar fasciitis. Further high-quality, comparative studies with longer clinical follow-up are required to support recommendations for use of PRP in the treatment of Achilles tendon pathology.