bluuebunny/crossref_metadata_2025_split huggingface dataset:
Quality of life in patients with heart failure and improved ejection fraction: one‐year changes and prognosis
Authors: Zamora Elisabet , González Beatriz , Lupón Josep , Borrellas Andrea , Domingo Mar , Santiago‐Vacas Evelyn , Cediel Germán , Codina Pau , Rivas Carmen , Pulido Ana , Crespo Eva , Velayos Patricia , Diaz Violeta , Bayes‐Genis Antoni 
Published: August 2022

AbstractAimsThe criteria for patients with heart failure (HF) and improved ejection fraction (HFimpEF) are a baseline left ventricular ejection fraction (LVEF) ≤40%, a ≥10‐point increase from baseline LVEF, and a second LVEF measurement >40%. We aimed to (i) assess patients with HF and reduced LVEF (HFrEF) at baseline and compare quality of life (QoL) changes between those that fulfilled and those that did not fulfil the HFimpEF criteria 1 year later and (ii) assess the prognostic role of QoL in patients with HFimpEF.MethodsWe reviewed data from a prospective registry of real‐world outpatients with HF that were assessed for LVEF and QoL at a first visit to the HF clinic and 1 year later. QoL was evaluated with the Minnesota Living with Heart Failure Questionnaire (MLWHFQ). The primary prognostic endpoint was the composite of all‐cause death or HF hospitalization.ResultsBaseline and 1‐year LVEF and MLWFQ scores were available for 1040 patients with an initial LVEF ≤40% (mean age, 65.2 ± 11.7 years; 75.9% men). The main aetiology was ischaemic heart disease (52.9%), and patients were mostly in New York heart Association Classes II (71.1%) and III (21.6%). At baseline, the mean LVEF was 28.5% ± 7.3, and the mean MLWHFQ score was 30.2 ± 19.5. After 1 year, the mean LVEF increased to 38.0% ± 12.2, and the MLWHFQ scores improved to 17.4 ± 16.0. In 361 patients that fulfilled the HFimpEF criteria (34.7%), significant improvements were observed in both LVEF (from 28.7% ± 6.6 to 50.9% ± 7.6, P < 0.001) and QoL (from 32.9 ± 20.6 to 16.9 ± 16.0, P < 0.001). Patients that did not fulfil the HFimpEF criteria also showed significant improvements in LVEF (from 28.4% ± 7.6 to 31.1% ± 7.9, P < 0.001) and QoL (from 28.7 ± 18.8 to 17.6 ± 15.9, P < 0.001). However, the QoL improvement was significantly higher in the HFimpEF group (−16.0 ± 23.8 vs. −11.1 ± 20.3, P = 0.001), despite the worse mean baseline MLWHFQ score, compared with the non‐HFimpEF group (P = 0.001). The 1‐year QoL was similar between groups (P = 0.50). The 1‐year MLWHFQ score was independently associated with outcomes; the hazard ratio for the composite endpoint was 1.02 (95% CI: 1.01–1.03, P = 0.006). In contrast, the QoL improvement (with a cut‐off ≥5 points) was not independently associated with the composite outcome.ConclusionsPatients with HFrEF showed improved QoL after 1 year, regardless of whether they met the HFimpEF criteria. The similar 1‐year QoL perception between groups suggested that factors other than LVEF influenced QoL perception. The 1‐year QoL was superior to the QoL change from baseline for predicting prognosis in patients with HFimpEF.
Post‐earthquake system identification and response estimation of an elastic compound building using a simplified numerical model
Authors: Lin Jui‐Liang , Yu Gee‐Jin , Chuang Ming‐Chieh , Lin Guan‐Hong , Weng Yuan‐Tao , Hwang Shyh‐Jiann , Tsai Keh‐Chyuan 
Published: July 2022

AbstractThe post‐earthquake system identification and response estimation of an elastic 13‐story compound building during four seismic events were effectively conducted using a simplified numerical model: the generalized building model (GBM). The compound building examined was the recently remolded office building of Taiwan's National Center for Research on Earthquake Engineering. The 7–13th stories of the building are extended steel structures seated atop six older reinforced‐concrete stories. In addition to the vertical extension, the building was horizontally extended. The extension incorporated several types of seismic dampers. The GBM, which reflects the dynamic characteristics of the elastic compound building, was constructed using only the acceleration records of the roof and the 7th story. The effectiveness of the GBM was then verified by comparing the estimated and actual acceleration responses of the other stories. From the verified GBM, the modal parameters and drift responses of the compound building were estimated accordingly.
Leveraging big data analytics in 5G‐enabled IoT and industrial IoT for the development of sustainable smart cities
Authors: Mukherjee Suprakash , Gupta Shashank , Rawlley Oshin , Jain Siddhant 
Published: July 2022

AbstractThere has been an exponential growth in the number of low‐cost heterogeneous sensor devices that are connected to the internet in the existing infrastructure of smart cities in the past decade. These sensors and actuator devices are employed in various industries to collect invaluable data that greatly impacts business decisions. State‐of‐the‐art research is being carried out to process the high‐volume data collected in high velocity streams with high variability in order to draw meaningful insights to cater to business needs in various domains. Big data analytics finds diversified opportunities in 5G‐enabled Internet of Things (IoT) and industrial IoT environment to study the data patterns and produce new results which provides big organizations a conducive environment to take informed decisions. This article presents an exhaustive investigation of the various applications and algorithms of the big data analytics in 5G‐driven IoT and industrial IoT systems with a detailed taxonomy of the existing analytical systems and also the challenges specific to the applications in an IoT environment. A holistic understanding on the importance of security and privacy of big data during the development of smart city infrastructure in high velocity streaming process has been explained for a broad understanding of the big data streaming processes. A thorough analysis of important data mining algorithms such as classification, association rule mining, clustering, and prediction methods for big IoT data from the recent literature also has been presented to provide a clear understanding of existing issues in handling big data in 5G‐enabled IoT for the development of sustainable smart city infrastructure.
Identification of Tartrazine adulteration and evaluating exposure to synthetic dyes of sunset yellow and Quinoline yellow through consumption of food products among children
Authors: Rahnama Hannaneh , Mazloomi Seyed Mohammad , Berizi Enayat , Abbasi Azam , Gholami Zahra 
Published: July 2022

AbstractExcessive consumption of synthetic food dyes by children may raise concerns about their health. These dyes may aggravate the hyperactivity symptoms and exacerbate asthma in sensitive children. The purpose of this study was to determine the presence of sunset yellow and quinoline yellow dyes, as well as tartrazine in dairy‐free fruit ice cream, freeze pop, jelly, and candy. Additionally, we evaluated the amount of two food dyes consumed by children. To do so, a total of 150 food samples, including 20 dairy‐free fruit ice creams, 25 freeze pops, 57 jelly products, and 48 types of candy were randomly selected from stores in Shiraz, Iran. Then, using the high‐performance liquid chromatography (HPLC) method and an ultraviolet (UV) detector, we measured the amounts of sunset yellow and quinoline yellow dyes and identified the use of tartrazine. Also, the per capita consumption (grams per day) of the mentioned foods was calculated using a checklist in two groups of male and female primary schoolchildren aged 6–9 years and 10–13 years in Shiraz, Iran. According to the results, 11 (7.33%) samples contained only tartrazine and 107 (71.33%) samples contained quinoline yellow and sunset yellow synthetic dyes. In addition, of 107 samples that used quinoline yellow and sunset yellow, 102 (95.33%) contained unauthorized tartrazine. Only seven (6.54%) samples contained exceedingly high concentrations of authorized quinoline yellow and sunset yellow synthetic dyes. However, the exposure assessment showed that the intake of quinoline yellow and sunset yellow was at average levels and the 95th percentile in both age groups was less than the associated acceptable daily intake (ADI). For synthetic dyes, the target hazard quotient (THQ) and hazard index (HI) were less than one, indicating that ingestion of these two dyes via food products does not pose a risk to children's overall health.
Dramatic response to entrectinib in a patient with malignant peripheral nerve sheath tumor harboring novel SNRNP70‐NTRK3 fusion gene
Authors: Kobayashi Hiroshi , Makise Naohiro , Shinozaki‐Ushiku Aya , Zhang Liuzhe , Ishibashi Yuki , Ikegami Masachika , Tsuda Yusuke , Kohsaka Shinji , Ushiku Tetsuo , Oda Katsutoshi , Miyagawa Kiyoshi , Aburatani Hiroyuki , Mano Hiroyuki , Tanaka Sakae 
Published: July 2022

AbstractNeurotropic tropomyosin receptor kinase (NTRK) gene rearrangements have been reported in limited cases of sarcomas; however, to date, there has been only one report of such rearrangements in malignant peripheral nerve sheath tumors (MPNSTs). Herein, we describe a 51‐year‐old male patient with a buttock tumor arising from the sciatic nerve, which was diagnosed as MPNST with positive S‐100 staining, negative SOX10 staining, and loss of trimethylation at lysine 27 of histone H3 (H3K27me3) confirmed by immunohistochemistry. Soon after the resection of the primary tumor, the patient was found to have pulmonary and lymph node metastases. Chemotherapy with eribulin and trabectedin showed limited effects. However, the patient responded rapidly to pazopanib, but severe side effects caused discontinuation of the treatment. RNA panel testing revealed a novel fusion gene between Small Nuclear Ribonucleoprotein U1 Subunit 70 (SNRNP70) gene and NTRK3 gene. Furthermore, loss of NF1, SUZ12, and CDKN2A genes was confirmed by DNA panel testing, which is compatible with a histological diagnosis of MPNST. SNRNP70 possesses a coiled‐coiled domain and seems to induce constitutive activation of NTRK3 through dimerization. In fact, immunohistochemistry revealed diffuse staining of pan‐TRK within tumor cells. Treatment with entrectinib, which is an NTRK inhibitor, showed a quick and durable response for 10 months. Although NTRK rearrangements are very rare in MPNST, this case highlights the importance of genetic testing in MPNST, especially using an RNA panel for the detection of rare fusion genes.
Impact of a prognostic model for overall survival on the decision‐making process in a head and neck cancer multidisciplinary consultation meeting
Authors: Dorr Maarten C. , Hoesseini Arta , Sewnaik Aniel , Hardillo José A. , Baatenburg de Jong Robert J. , Offerman Marinella P. J. 
Published: July 2022

AbstractBackgroundMultidisciplinary decision‐making in head and neck cancer care is complex and requires a tradeoff between prolonging survival and optimizing quality of life. To support prognostication and decision‐making in head and neck cancer care, an individualized prognostic model for overall survival (OncologIQ) is available.MethodsBy quantitative and qualitative research we have studied user value of OncologIQ and its impact on the decision‐making process in a multidisciplinary consultation meeting.ResultsHealthcare professionals experienced added value upon using prognostic estimates of survival from OncologIQ in half (47.5%) of the measurements. Significant impact on the decision making process was seen when OncologIQ was used for older patients, patients having a WHO performance score ≥ 2, or high tumor stage.ConclusionsThe prognostic model OncologIQ enables patient‐centered decision‐making in a multidisciplinary consultation meeting and was mostly valued in complex patients.
Macroeconomic effects of global policy and financial risks
Authors: Ogawa Eiji , Luo Pengfei 
Published: July 2022

AbstractGlobalization has brought larger spillovers of global risks across borders since the 2000s. Specifically, global policy risk has sharply increased due to policy uncertainty in major countries in the recent decade as are shown in the Brexit, the US‐China trade friction and the COVID‐19 pandemic. This paper empirically investigates effects of both global policy risk and global financial risk on macroeconomy and financial markets in eight major countries from January 1997 to June 2020. We employed a structural vector autoregressive framework to obtain interesting empirical results. First, global risks have recessionary effects on the macroeconomy, reducing production, deteriorating employment, lowering long‐term interest rates, depressing prices and reducing global trade. Second, global risks also have recessionary effects on financial markets, plunging stock prices, appreciating the safe‐haven currencies and depreciating the other currencies. Third, the macroeconomies and the financial markets respond to the global financial risk more significantly than the global policy risk. Fourth, the recessionary effects of global risks vary depending on countries.
Dramatic response to pembrolizumab after pseudoprogression in a patient with advanced metastatic castration‐resistant prostate cancer
Authors: Kageyama Takumi , Soga Norihito , Sekito Sho , Kato Seiichi , Ogura Yuji , Kojima Takahiro , Kanai Masahiro , Inoue Takahiro 
Published: August 2022

IntroductionProstate cancer with a microsatellite instability‐high or mismatch repair‐deficient status is not common. Few reports of the response to pembrolizumab in metastatic castration‐resistant prostate cancer in a real‐world setting have been reported. This case report describes a dramatic response to pembrolizumab after initial pseudoprogression in a patient with microsatellite instability‐high metastatic castration‐resistant prostate cancer.Case presentationA 70‐year‐old man was administered pembrolizumab for metastatic castration‐resistant prostate cancer after the genetic evaluation of lymphadenectomy revealed a microsatellite instability‐high status. His general condition dramatically improved after pseudoprogression. His favorable condition has been maintained for 1 year since the final dose.ConclusionWe experienced a case of dramatic response to pembrolizumab after pseudoprogression in a patient with advanced metastatic castration‐resistant prostate cancer. In patients with metastatic castration‐resistant prostate cancer and the microsatellite instability‐high/mismatch repair‐deficient phenotype, a few months follow‐up is necessary to evaluate the efficacy of pembrolizumab.
Nanoscale surface dynamics of spatial patterns of polymeric bilayered particles loaded with essential oil
Authors: Matos Robert Saraiva , da Costa Ítalo Carvalho , Yasumura Heloisa David , de Azevedo Sidney Gomes , Sanches Edgar Aparecido , da Fonseca Filho Henrique Duarte 
Published: August 2022

AbstractGelatin/PCL bilayered particles loaded with Piper nigrum essential oil was synthesized aiming to access their morphological and surface dynamic patterns. Atomic force microscopy (AFM) was applied to investigate the 3D morphology and multifractal aspects of the particles surface. The AFM maps revealed spherical surfaces and well dispersed particles, besides a rougher surface on the loaded system. Minkowski functionals showed that shape of the rough peaks was similar in the unloaded and loaded systems; however, the presence of deep valleys on the loaded particles revealed their rougher pattern. Multifractal analysis revealed that unloaded and loaded particles presented multifractal behavior with different surface dynamics. The loaded surface presented a greater width of the multifractal spectrum and smaller difference of fractal dimensions, confirming their more vertically growing. These results can be useful in the development of novel polymeric‐based particles loaded with essential oil. Their unique surface dynamics can provide enhanced physical properties and performance in emerging biotechnological applications.
Ethical implications of early genetic diagnosis in an infant with Lesch–Nyhan syndrome
Authors: Zhang Tian , Briere Julie M. , Leeman Kristen T. , Wojcik Monica H. , Agrawal Pankaj B. 
Published: August 2022

AbstractPathogenic variants in HPRT1 lead to deficiency in hypoxanthine‐guanine phosphoribosyltransferase and are responsible for a spectrum of disorders. The severe phenotype is termed Lesch–Nyhan syndrome (LNS) and is inherited in an X‐linked recessive manner. Most individuals with LNS have profound intellectual and physical disabilities throughout life including self‐mutilating behaviors. Here, we present the case of a male infant who was diagnosed with LNS at 3 weeks of age via rapid exome sequencing (ES), which revealed a hemizygous maternally inherited deletion of at least 1.3 Mb of Xq26.3, including exons 2 to 9 of HPRT1. We discuss the critical time points leading to this diagnosis while highlighting his parents' values that guided the decision‐making. Genetic testing provided an early diagnosis for this infant that led to important considerations regarding goals of care in addition to raising new ethical concerns. This highlights the important role that early and rapid diagnostic genetic testing can play in helping families make difficult decisions. Additionally, this case highlights the complexity of discussing rare genetic diagnoses with families and facilitating critical discussions to empower the family toward making an informed decision.
Epstein–Barr virus seroprevalence and viral load at disease onset in children with inflammatory bowel disease
Authors: Kornitzer Gaël , Rosenstein Michelle , Turcotte Marie‐Catherine , Godin David , Groleau Véronique , Renaud Christian , Touzot Fabien , Jantchou Prevost , Ovetchkine Philippe , Deslandres Colette 
Published: July 2022

AbstractBackground and AimPatients with inflammatory bowel disease (IBD) are at increased risk for life‐threatening complications of Epstein–Barr virus (EBV), including lymphoproliferative diseases. These complications are likely related to inherent immune dysfunction and immunomodulating therapies often used. We aimed to determine the seroprevalence of EBV at diagnosis in our population, its impact on disease at onset, and the risk of active EBV infection.MethodsWe included patients newly diagnosed with IBD for whom an EBV serology was performed over a 2‐year period. Demographic information and data on disease characteristics were collected retrospectively. Stored serum from the time of diagnosis was retrieved when available for the patients with positive EBV serology, and quantitative polymerase chain reaction testing was performed to assess the pre‐treatment viral load of EBV.ResultsOne hundred twenty patients were included in the study. Fifty‐three patients (44.2%) had positive EBV serology at diagnosis. Stratified by age group, the prevalence of seropositive patients was for 0 to <10 years 35%, 10 to <17 years 46%, and ≥17 years 50%. Overall, therapies started within 6 months of diagnosis were similar in both the seropositive and seronegative groups. Within the seropositive group, 66% received systemic corticosteroids, 32.1% infliximab, 5.7% adalimumab, and 5.7% azathioprine.ConclusionEBV seroprevalence is high in pediatric patients with IBD. EBV seropositivity did not seem to influence the severity of disease at onset or initial choice of therapy.
Clinical features of capsule endoscopy in young adults: A single‐center retrospective study
Authors: Xu Hui‐Wen , Chen Yi‐Ru , Wang Mei‐Qian , Zhu Sen‐Lin 
Published: August 2022

AbstractBackground and AimCapsule endoscopy (CE) has been used in clinical examination among people of various ages, while few studies exclusively focused on the young. We aimed to explore its clinical features in young adults and those with obscure gastrointestinal bleeding (OGIB).MethodsA total of 479 young adults aged 18–44 years were analyzed, with median age of 33 years. Primary positive findings of patients were classified into four kinds of lesions, and potential risk of bleeding among patients with OGIB was assessed based on Saurin classification (P0‐2 lesions).ResultsThe overall completion rate and diagnostic yield of CE among young adults were 89.77 and 77.04%, respectively. Significant differences were found among overall completion rate/diagnostic yield and inpatient status/CE brand. Positive diagnostic yield among 157 patients with OGIB was 51.59% (P1‐2 lesions), and the significant risk of bleeding was 37.04% (P2 lesions). Among patients with OGIB in which 134 patients with a total of 216 lesions, ulceration was the commonest P2 lesions, followed by angioectasia and telangiectasia. Inpatient rate, completion rate, and diagnostic yield were higher among patients with overt OGIB, and disease categories of overt OGIB were different compared with occult OGIB.ConclusionCE is an optimal tool for discovering lesions in young adults and could play a role in evaluating the bleeding risk of young adults with OGIB.
The mod k $k$ chromatic index of graphs is O(k) $O(k)$
Authors: Botler Fábio , Colucci Lucas , Kohayakawa Yoshiharu 
Published: July 2022

AbstractLet denote the minimum number of colors needed to color the edges of a graph in a way that the subgraph spanned by the edges of each color has all degrees congruent to . Scott proved that , and thus settled a question of Pyber, who had asked whether can be bounded solely as a function of . We prove that , answering affirmatively a question of Scott.
Capability‐sensitive principles for assistive technology to support young graduates with disabilities in Bangladesh and Kenya into employment
Authors: Morris Lisa‐Dionne , Abu Alghaib Ola , Northridge James 
Published: July 2022

AbstractOwing to increased inclusion of young people with disabilities into the private sector in Bangladesh and Kenya, there is an urgent need to find alternative ways to support young graduates with a disability in the workplace with assistive technology solutions. The aim of the paper is to identify barriers for private workplace sectors to use assistive technology to support young graduates seeking, maintaining and retaining employment. This qualitative study adopted the research onion design of Saunders et al. Data were collected using interviews and focus group discussions and analysed using thematic analysis. The findings reveal that barriers are linked to seven key person‐centred capability themes: the dream, external factors, internal factors, assistive technology vision, strategic design priorities and gaps and assistive actions.