bluuebunny/crossref_metadata_2025_split huggingface dataset:
Outcome of a de-labelling algorithm compared with results of penicillin (β-lactam) allergy testing
Authors: Schrüfer Philipp , Stoevesandt Johanna , Trautmann Axel 
Published: March 2022

Abstract
Background
Penicillin allergy labels frequently impede guideline-directed treatment with a penicillin or other β-lactam antibiotics. Despite presumed allergy, targeted questioning may indicate a low probability of sensitization and permit reasonably safe administration of the antibiotic in question. In this study, we evaluated a standardized algorithm aiming to differentiate non-allergic patients from those with true allergic β-lactam hypersensitivity.

Methods
We retrospectively applied a de-labelling algorithm in 800 consecutive patients with suspected β-lactam hypersensitivity. All had undergone complete allergy work-up permitting to definitely exclude or diagnose β-lactam allergy between 2009 and 2019.

Results
In 595 (74.4%) out of 800 cases evaluated, β-lactam allergy could be excluded by negative challenge testing. IgE-mediated anaphylaxis was diagnosed in 70 (8.7%) patients, delayed-type hypersensitivity in 135 (16.9%). In 62 (88.6%) anaphylaxis cases, the algorithm correctly advised to use an alternative antibiotic. Accuracy was higher in patients with moderate to severe anaphylaxis (97.7%) compared to those with a history of mild reactions (73.1%). The algorithm correctly identified 122 (90.4%) patients with proven delayed-type hypersensitivity. It permitted de-labelling in 330 (55.5%) out of 595 patients with diagnostic exclusion of penicillin hypersensitivity, but failed to identify the remaining 265 (44.5%) as low-risk cases.

Conclusions
The algorithm detected 89.8% of cases with penicillin (β-lactam) allergy, sensitivity was optimal for moderate to severe anaphylaxis. Study data justify the implementation of a standardized de-labelling algorithm under close supervision in order to permit guideline-directed treatment and reduce the use of broad-spectrum antibiotics as part of an antibiotic stewardship program.
Allergy-related outcomes and sleep-related disorders in adults: a cross-sectional study based on NHANES 2005–2006
Authors: Xi Yang , Deng Yu-Qin , Chen Shi-Ming , Kong Yong-Gang , Xu Yu , Li Fen , Jiao Wo-Er , Lu Gan , Tao Ze-Zhang 
Published: March 2022

Abstract
Background
Epidemiological evidence between the sleep disorders and allergy-related outcomes is limited.

Objectives
The purpose of the present study was to estimate the relationship between sleep disorders and allergy-related outcomes in adults.

Methods
We built logistic regression models to examine the associations between sleep disorders and allergy-related outcomes in adult participants using the 2005–2006 NHANES database. Allergy-related outcomes included sIgE levels, asthma, hay fever, sneezing, wheezing, and eczema. Sleep disorders included sleep latency, sleep length, sleep problems, OSA symptoms, and daytime sleepiness. A t-test was used for between-group comparisons.

Results
Participants with OSA symptoms had 2.72 × higher odds of experiencing hay fever and 1.54 × higher odds of having eczema compared to Non-OSA symptoms participants. Participants with insufficient sleep (≤ 6 h/night) had 1.27 × higher odds of developing allergic sensitisation compared to participants with adequate sleep (7–8 h/night). Sneezing was positively associated with sleep problems (OR: 1.706; 95% CI 1.386, 2.099), OSA symptoms (OR: 1.297; 95% CI 1.049, 1.605), and daytime sleepiness (OR: 1.569; 95% CI 1.205, 2.04).

Conclusion
Our findings suggest a positive association between allergy-related outcomes and sleep disorders. In particular, OSA symptoms, daytime sleepiness, and sleep problems are strongly associated with allergic conditions.

Graphical Abstract
What radiologists need to know about patients’ expectations: P.A.T.I.E.N.T.S C.A.R.E.R.S A.I.M.S
Authors:   European Society of Radiology (ESR), Carrié Dominique , Cruwys Cheryl , Brady Adrian , Bauer Birgit , England Andrew , Traykova Nikoleta , Justich Caroline , Briers Erik , Birch Judy , Bargalló Alabart Núria , Rockall Andrea , Karantanas Apostolos , Catalano Carlo 
Published: March 2022

AbstractThe Patient Advisory Group (PAG) of the European Society of Radiology aims to highlight, in this short paper, patients’ expectations from the radiological community and support workers, throughout the patient’s medical imaging journey for completion of diagnostic or interventional examinations. In order to maintain constant awareness of patients’ expectations, key expectations have been summarised in an easy-to-remember mnemonic: PATIENTS CARERS AIMS.Due to disparate healthcare systems and medical imaging services in Europe, not all patient expectations can be systematically met, but healthcare providers should be mindful, when setting up new operational procedures, of the need to focus on patient-centred needs and care. At times when new or improved technology is being introduced, such as artificial intelligence applications, telemedicine, robotisation of interventional procedures and digitised records, the impact on radiologist–patient communication and interactions should be considered.
Development of a segregation method to sort fast-grown Eucalyptus nitens (H. Deane & Maiden) Maiden plantation trees and logs for higher quality structural timber products
Authors: Balasso Michelle , Hunt Mark , Jacobs Andrew , O’Reilly-Wapstra Julianne 
Published: March 2022

Abstract
Key message
A method to segregate trees and logs of planted Eucalyptus nitens (H. Deane & Maiden) Maiden has been developed, showing that accounting for wood quality during the process of segregation and sorting of timber resources allows for the recovery of structural timber of the desired quality.

Context
Appropriate sorting of raw forest resources is necessary to allocate logs to different production streams, to ensure that the desired quality of timber is achieved. Acoustic wave velocity can be used to test the wood quality of trees and logs, and its use as a sorting tool needs to be investigated prior to the development of a segregation method to recover high-quality timber.

Aims
This study aimed to develop a segregation methodology for plantation E. nitens trees and logs to obtain high-quality structural boards.

Methods
Forty-nine logs of planted E. nitens were measured, assessed with acoustic wave velocity, and processed into 268 structural boards maintaining board, log, and tree identity. Board stiffness was determined via structural testing and boards were ranked in structural grades. Linear mixed effect models were used to predict board stiffness based on tree and log variables, and machine learning decision trees were used to create a segregation method for board grades. Different segregation options were compared through scenario simulation.

Results
The prediction of individual board stiffness with tree or log variables yielded low coefficients of variation due to large intra-log variability (R2 = 0.22 for tree variables and R2 = 0.28 for log variables). However, the decision tree identified acoustic wave velocity thresholds to segregate E. nitens trees and logs. When applied in scenario simulation, segregation based on log variables produced the best results, resulting in large shares of high-quality board grades, showing that a segregation method based on wood quality traits can yield larger higher recovery of higher quality timber, in respect to other scenarios.

Conclusion
Acoustic wave velocity can be used to segregate trees and logs for structural boards from plantation E. nitens, and machine learning decision trees can support the development of a segregation method to determine operational thresholds to increase the recovery of high-quality timber.
Automatic kidney segmentation using 2.5D ResUNet and 2.5D DenseUNet for malignant potential analysis in complex renal cyst based on CT images
Authors: Kittipongdaja Parin , Siriborvornratanakul Thitirat 
Published: March 2022

AbstractBosniak renal cyst classification has been widely used in determining the complexity of a renal cyst. However, it turns out that about half of patients undergoing surgery for Bosniak category III, take surgical risks that reward them with no clinical benefit at all. This is because their pathological results reveal that the cysts are actually benign not malignant. This problem inspires us to use recently popular deep learning techniques and study alternative analytics methods for precise binary classification (benign or malignant tumor) on Computerized Tomography (CT) images. To achieve our goal, two consecutive steps are required–segmenting kidney organs or lesions from CT images then classifying the segmented kidneys. In this paper, we propose a study of kidney segmentation using 2.5D ResUNet and 2.5D DenseUNet for efficiently extracting intra-slice and inter-slice features. Our models are trained and validated on the public data set from Kidney Tumor Segmentation (KiTS19) challenge in two different training environments. As a result, all experimental models achieve high mean kidney Dice scores of at least 95% on the KiTS19 validation set consisting of 60 patients. Apart from the KiTS19 data set, we also conduct separate experiments on abdomen CT images of four Thai patients. Based on the four Thai patients, our experimental models show a drop in performance, where the best mean kidney Dice score is 87.60%.
What is the effect on antibiotic resistant genes of chlorine disinfection in drinking water supply systems? A systematic review protocol
Authors: Ghordouei Milan Esfandiar , Mahvi Amir Hossein , Nabizadeh Ramin , Alimohammadi Mahmood 
Published: March 2022

Abstract
Background
Antibiotic-resistant bacteria (ARB) usually enter water sources in different ways, such as via municipal and hospital wastewaters. Because conventional technologies used to treat water inefficient in removing these contaminants (especially antibiotic-resistant genes; ARGs), these contaminants easily enter drinking water distribution networks and pose serious threats to consumers’ health. This study’s main purpose is to systematically investigate the effect of chlorine disinfection on ARGs in drinking water supply systems. This study could play an important role in elucidating the effect of chlorine disinfection on ARGs.

Methods
The systematic review outlining this protocol will be performed according to the Collaboration for Environmental Evidence (CEE) guidelines. The main question is, “what is the effect of chlorine disinfection on ARGs in drinking water supply systems?” For this purpose, the articles will be considered, in which chlorine’s effect on ARGs is investigated. The search includes electronic resources, grey literature, and related websites. Electronic resources include Scopus, PubMed, Embase, Web of Science Core Collection, and Science Direct. After the final search, the obtained articles will be collected in the reference management software (Endnote X8). Upon removing the duplicate articles, the first stage of article screening will be performed based on the title and abstract the articles. In the second stage, the articles obtained from the first screening stage will be screened based on the full text of the articles based on the eligibility criteria. Then, two members of the expert team extract the data. To assess the validity of the articles, bias sources will be determined by an expert team. Biases will be defined according to the criteria designed by Bilotta et al. Finally, a narrative synthesis will be performed for the extracted data; if appropriate data are available, quantitative analysis will also be performed.
Impact of Mixing Methods and Cement Dosage on Unconfined Compressive Strength of Cement-Stabilized Macadam
Authors: Zhao Kaiyin , Zhao Lijun , Hou Jinru , Feng Zhongxu , Jiang Wenzhi 
Published: March 2022

AbstractThe technology of vibratory mixing has been applied to improve the compressive strength of cement-stabilized macadam (CSM). The aim of this study is to investigate the effect of vibration acceleration and cement dosage on the unconfined compressive strength and density of CSM. The mixtures with four cement dosages (2%, 3%, 4%, and 5%) were prepared by conventional mixing (0 g) and vibratory mixing (1 g, 2 g, and 3.5 g). The unconfined compressive strength was tested under different mixing methods. And the microstructure of CSM was analyzed by scanning electron microscope. The results indicate that samples using vibratory mixing have higher strengths, lower coefficient of variation, and denser microstructures, compared with the conventional compulsory mixing. Compared with 15% in conventional mixing, the strength variable coefficient of CSM is less than 10% in the vibratory mixing method. As the cement dosage and the vibration acceleration increase, the unconfined compressive strength increases. However, cement dosage has a more significant influence on improving the unconfined compressive strength than the mixing method. With the increase of every 1% in cement dosage, the 7-day strength of conventional mixing and in vibratory mixing average increased by 59% and 38%, respectively. However, the maximum improvement rate of the UCS value is 20–56.7% when vibration acceleration increased from 0 to 1 g. Especially when cement dosage is high, the effect of vibratory mixing on improving strength is limited. Besides, vibratory mixing reduces the original cement dosage by over 1.6% with the qualified unconfined compressive strength at vibration acceleration of 2 g, which is recommended in construction practice.
Self-care practice among adult hypertensive patients at ambulatory clinic of tertiary teaching Hospital in Ethiopia: a cross-sectional study
Authors: Melaku Tsegaye , Bayisa Bodena , Fekeremaryam Helen , Feyissa Alemayehu , Gutasa Alemayehu 
Published: March 2022

Abstract
Background
Globally, hypertension is a major public health problem and a strong predictor of cardiovascular disease complications. To reduce and prevent complications from hypertension, it is important to adapt self-care behaviors. This study aimed to assess the self-care practices of adult hypertensive patients at a tertiary teaching hospital in Ethiopia.

Methods
A health facility-based prospective cross-sectional study was conducted at Jimma Medical Center in Ethiopia between February 2021 and July 2021. Binary and logistic regression was performed to assess the strength of associations between independent and dependent variables. Data entry and analysis were done using Statistical Package for social science (SPSS) software version 22.0. A p-value < 0.05 was considered to declare statistical significance.

Results
From a total of 422 respondents included to the study, male accounted 55.7% and the mean ± SD age of the respondents was 58.7 ± 9.75 years. About 53.1% of patients had poor self-care practices toward hypertension. Not attending formal education [AOR = 2.15; 95% CI (1.74, 6.39); p ≤ 0.001], uncontrolled blood pressure [AOR = 2.14 95% CI (1.27, 3.61); p = 0.003], chronic disease co-morbidity [AOR = 1.48; 95% CI (0.25, 7.73); p ≤ 0.001], unfavorable attitude toward hypertension[AOR = 3.13; 95% CI (1.95, 7.52); p ≤ 0.001], and poor social support [AOR = 2.75; 95% CI (1.45, 6.43); p ≤ 0.001] were independent predictors of poor self-care practice.

Conclusion
The level of self-care practices for hypertension in the study area was low. In particular, the level of adherence to the DASH diet, exercise, and weight control was very low. Patient-specific targeted interventions are required to improve self-care practices for hypertension.
Spinal anesthesia for cesarean section in a woman with an intrathecal baclofen pump
Authors: Allen Heath , Komatsu Ryu , El-Omrani Hani 
Published: March 2022

Abstract
Background
Intrathecal baclofen pumps are commonly used for the management of lower extremity spasticity in the setting of spinal cord injury. There have been no reports of the performance of spinal anesthesia in patients with a pre-existing intrathecal baclofen pump.

Case presentation
A 29-year-old parturient presented for cesarean section. She had a history of spinal cord injury due to fractures of the thoracic vertebrae with lower extremity spasticity, which had been treated with an intrathecal baclofen pump inserted through lumbar (L) 3-L4 intervertebral space. Preoperative lumbosacral ultrasound was performed to identify the L4-5 interspace, and spinal anesthesia was performed through that space with a 25-gauge 3.5-inch-long Whitacre spinal needle. Thoracic (T) 4 dermatomal level anesthesia was achieved, and the patient underwent the cesarean section without requiring additional intravenous analgesic adjuncts.

Conclusions
Spinal anesthesia can be successfully performed in patients with intrathecal baclofen pumps. Existing intrathecal catheters can be located with preoperative imaging, and ultrasound can be used to determine the vertebral levels below the intrathecal catheter through which spinal anesthesia can be performed safely.
Gene expression trend changes in breast cancer populations over two decades: insights from The Cancer Genome Atlas database
Authors: Wu Jinbo , Liu Hongjun , Hu Taobo , Wang Shu 
Published: March 2022

Abstract
Background
Breast cancer has remained the most common malignancy in women over the past two decades. As lifestyle and living environments have changed, alterations to the disease spectrum have inevitably occurred in this time. As molecular profiling has become a routine diagnostic and objective indicator of breast cancer etiology, we analyzed changes in gene expression in breast cancer populations over two decades using The Cancer Genome Atlas database.

Methods
We performed Heatmap and Venn diagram analyses to identify constantly up- and down-regulated genes in breast cancer patients of this cohort. We used Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses to visualize associated functional pathways.

Results
We determined that three oncogenes, PD-L2, ETV5, and MTOR and 113 long intergenic non-coding RNAs (lincRNAs) were constantly up-regulated, whereas two oncogenes, BCR and GTF2I, one tumor suppression gene MEN1, and 30 lincRNAs were constantly down-regulated. Up-regulated genes were enriched in “focal adhesion” and “PI3K-Akt signaling” pathways, etc., and down-regulated genes were significantly enriched in “metabolic pathways” and “viral myocarditis”. Eight up-regulated genes exhibited doubled or higher expression and the expression of three down-regulated genes was halved or lowered and correlated with long-term survival.

Conclusions
In this study, we found that gene expression and molecular pathway enrichments are constantly changing with time, importantly, some altered genes were associated with prognostics and are potential therapeutic targets, suggesting that the current molecular subtyping system must be updated to keep pace with this dynamic change.
Learning analytics to develop future competences in higher education: a case study
Authors: Kleimola Riina , Leppisaari Irja 
Published: March 2022

AbstractHigher education institutions are challenged to develop innovative educational solutions to meet the competence development requirements set by the emerging future. This qualitative case study aims to identify the future competences considered important for higher education students to acquire during their studies and how the development of these competences can be supported with learning analytics. Reflection on these issues is based on three dimensions (subject development, object, and social environment) of future competences. A special emphasis is placed on the views of 19 teaching professionals gathered from group interviews and analyzed through a qualitative content analysis. The findings indicate that subject development-related future competences, such as reflective competence, self-awareness and self-management, learning literacy, and personal agency and self-efficacy were strongly identified as necessary future competences. The potential of learning analytics to support their development was also widely recognized as it provides means to reflect on learning and competence development and increase one’s self-awareness of strengths and weaknesses. In addition, learning analytics was considered to promote goal-orientation, metacognition and learning to learn, active engagement as well as learning confidence. To deal with complex topics and tasks, students should also acquire object-related competences, such as changeability and digital competence. In addition, they need cooperation and communication competence as well as a developmental mindset to operate successfully in social environments. The use of learning analytics to support most of these object and social environment-related competences was considered promising as it enables the wide exploitation of digital tools and systems, the analysis and visualization of social interactions, and the formation of purposeful learning groups and communal development practices. However, concrete ways of applying learning analytics were largely unacknowledged. This study provides useful insights on the relationship of important future competences and learning analytics while expanding on previous research and conceptual modelling. The findings support professionals working at higher education institutions in facilitating successful conditions for the development of future competences and in advancing purposeful use of learning analytics.
Australian Cancer Physicians and the Pharmaceutical Industry: A Survey of Attitudes and Interactions
Authors: Pokorny Adrian M.J. , Moynihan Ray , Fox Peter , Karikios Deme J. , Bero Lisa A. , Mintzes Barbara J. 
Published: March 2022

PURPOSE: Interactions between cancer physicians and the pharmaceutical industry may create conflicts of interest that can adversely affect patient care. We aimed to survey cancer physicians regarding their attitudes toward and interactions with industry. METHODS: We surveyed Australian cancer physicians between December 2020 and February 2021, questioning how often they interacted with industry and their attitudes toward this. We also assessed factors associated with accepting payments from industry and the amount received, and opinions on policies and industry influence. We used logistic and linear regression to examine links between attitudes and behaviors. RESULTS: There were 116 responses (94 complete). Almost half (n = 53 of 115, 46.1%) felt that there was a positive relationship between cancer physicians and industry. Most (n = 79 of 104, 76.0%) interacted with industry at least once a month, and 67.7% (n = 63 of 93) had received nonresearch payments from industry previously, with a median value of 2,000 Australian dollars over 1 year. Most respondents believed that interactions could influence prescribing while simultaneously denying influence on their own prescribing (n = 66 of 94, 70.2%). Those who judged general sales representative interactions (odds ratio [OR] 9.37 [95% CI, 1.05 to 83.41], P = .045) or clinician sponsorship (OR 3.22 [95% CI, 1.01 to 10.30], P = .049) to be more acceptable also met with sales representatives more frequently. Physicians were more likely to accept industry payments when they deemed sponsorship of clinicians for conferences (OR 10.55 [95% CI, 2.33 to 47.89], P = .002) or honoraria for advisory board membership more acceptable (OR 3.91 [95% CI, 1.04 to 14.74], P = .04) or when they had higher belief in industry influence over own prescribing (OR 25.51 [95% CI, 2.70 to 241.45], P = .005). CONCLUSION: Australian cancer physicians interact with industry frequently, and those who feel positive about these interactions are likely to do so more often. More research is needed to understand the motivations behind these interactions.