bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical utility of skin perfusion pressure measurement in diabetic foot wounds: An observational study
Authors: Kim Hak Jun , Kim Woo Jong , Lee Hong Seop , Koh Yeong Yoon , Shin Young Bin , Yeo Eui Dong 
Published: September 2022

The degree of blood vessel stenosis significantly influences diabetic foot treatment. This study aimed to investigate the association between computed tomography angiography (CTA) stenosis and skin perfusion pressure (SPP), which are noninvasive vascular assessments used to evaluate diabetic foot wounds.
Forty patients who reported diabetic foot wounds between November 2016 and December 2017 were included in the study. SPPand CTA were performed to evaluate the blood flow, and the rate of decrease in wound size was measured for the wounds corresponding to Meggitt–Wagner grade 1 at the first evaluation and 4-week intervals.
The P value of the association between the degree of CTA stenosis and the SPP value was 0.915, and the P value of the association between CTA stenosis and decreasing rate of wound size was .235. There was no statistically significant association between SPP and the decreasing rate of wound size according to the degree of CTA stenosis. The association between SPP value and the decreasing rate of wound size was statistically significant (P < .05).
The decreasing rate in diabetic foot wound size was significantly associated with SPP but not with CTA stenosis.
Relationship between plasma fibrinogen degradation products(FDP) and D-dimer levels and disease activity in rheumatoid arthritis: A STROBE compliant article
Authors: Qiang FuYong , Xu Hui , Sheng Jun 
Published: September 2022

In this study, we aimed to investigate whether fibrinogen degradation products(FDP)and D-dimer could be used as serological indicators of rheumatoid arthritis(RA) activity, such as erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), and platelets (PLT).
A total of 112 consecutive patients with RA between July 2018 and July 2020 were divided into moderate and high disease activity groups (disease activity score 28(DAS28) > 3.2, n = 60) and low disease activity and remission groups (DAS28≤3.2, n = 52). A total of 50 healthy volunteers were included in the control group, and FDP and D-dimer levels were compared across the three groups. The correlations of FDP and D-dimer levels with ESR, CRP, PLT, and DAS28 were analyzed. Analyses of the receiver operating characteristic(ROC) curves and area under the ROC curve (AUC) of FDP, D-dimer, ESR, CRP, and PLT levels were performed.
FDP and D-dimer levels were significantly higher in the high-activity compared to the low-activity and remission (P < .001), and the control (P < .001). No significant differences in FDP and D-dimer were observed between the low-activity and remission and the control (P > .05). FDP and D-dimer levels were positively correlated with ESR, CRP, PLT, and DAS28 (all P < .001). The ROC curves showed that the FDP and D-dimer levels could be used to evaluate the RA activity (all P < .001). The AUC of FDP was significantly larger than that of PLT (P = .047). FDP and D-dimer can be used as supplementary serological indicators to assess RA activity, in addition to ESR, CRP, and PLT.
Visualized analysis of research on helicopter emergency medical service
Authors: Peng Cheng , Su Pan 
Published: September 2022

Background:
Numerous studies have confirmed that helicopter emergency medical services (HEMS) play a positive role in prehospital care. However, few studies have used rigorous bibliometric tools to analyze the knowledge structure and distribution of HEMS research.

Objectives:
The purpose of this study was to use bibliometric methods to conduct a quantitative and qualitative analysis of the HEMS-related literature and to determine the research status and hotspots of HEMS research.

Methods:
CiteSpace was used for bibliometric analysis of the HEMS-related literature retrieved from the Web of Science database from 1989 to 2021.

Results:
A total of 1378 HEMS-related literature were included. Collaboration among countries, authors, and institutions needs to be strengthened. The topics in HEMS research have mainly focused on the effectiveness of helicopter emergency medical services for trauma patients and the comparison of transport effectiveness between helicopters and ground emergency medical services on trauma patient transport. Research over the past 10 years has mainly focused on the application of HEMS in patients with trauma, myocardial infarction, cerebral apoplexy, application of tracheal intubation technology in HEMS, and advanced airway management. In recent years, HEMS research trends have mainly included out-of-hospital cardiac arrest, and transport.

Conclusions:
CiteSpace was used to visualize and analyze the HEMS-related literature, which visually reflected the research status and hot spots, providing references for the topic selection and development direction of HEMS research.
Randomized, direct comparison study of Saccharomyces boulardii CNCM I-745 versus multi-strained Bacillus clausii probiotics for the treatment of pediatric acute gastroenteritis
Authors: Altcheh Jaime , Carosella Mabel V. , Ceballos Ana , D’Andrea Ulises , Jofre Sandra M. , Marotta Carolina , Mugeri Domingo , Sabbaj Liliana , Soto Adriana , Josse Constant , Montestruc Francois , McFarland Lynne V. 
Published: September 2022

Background:
The choice of an appropriate probiotic for pediatric acute gastroenteritis (PAGE) can be confusing. Our aim was to compare the efficacy and safety of 2 probiotics (Saccharomyces boulardii CNCM I-745 vs a 4-strain mixture of Bacillus clausii O/C, SIN, N/R, T) for the treatment of PAGE.

Methods:
A 2-arm parallel, randomized trial recruited children (6 months to 5 years old) with mild-moderate acute diarrhea, from 8 centers in Argentina. A total of 317 children were enrolled and blindly randomized to 5 days of either S boulardii CNCM I-745 (n = 159) or a 4-strain mixture of B clausii (n = 158), then followed for 7 days post-probiotic treatment. A stool sample was collected at inclusion for pathogen identification. The primary outcome was duration of diarrhea defined as the time from enrollment to the last loose stool followed by the first 24-hour period with stool consistency improvement. Secondary outcomes included frequency of loose stools/day, severity of diarrhea, number reporting no diarrhea at Day 6, time-to-first formed stool, recurrence of diarrhea by study end (Day 12) and safety outcomes.

Results:
Three hundred twelve (98%) children completed the study. S boulardii CNCM I-745 showed a significant reduction (P = .04) in the mean duration of diarrhea (64.6 hours, 95% confidence interval [CI] 56.5–72.8) compared to those given B clausii (78.0 hours, 95% CI 69.9–86.1). Both probiotics showed improvement in secondary outcomes and were well-tolerated.

Conclusion:
In this study, S boulardii CNCM I-745 demonstrated better efficacy than B clausii mix for reducing the duration of pediatric acute diarrhea.
Anti-osteoporosis treatments changed body composition in postmenopausal women: A systematic review and meta-analysis
Authors: Shi Lingfeng , Xu Xiaoli , Xiang Guangda , Duan Shanshan 
Published: September 2022

Background:
Whether the widespread anti-osteoporosis treatments in postmenopausal women also benefit the change of body composition (lean body mass [LBM] and body fat mass [FM]) remains controversial. In order to solve this issue and find out the most effective treatment, we conducted this meta-analysis.

Methods:
We searched the literature, via PubMed, Embase, Scopus, Web of Science, and Cochrane to screen citations from inception to March 26, 2022, for inclusion in this study. Only clinical trials that used anti-osteoporosis treatments in postmenopausal women and displayed the alteration of body composition were included. Stata 14.0 was used for the meta-analysis.

Results:
Our meta-analysis results presented that: compared with placebo, hormone replacement therapy (HRT) was associated with increased LBM (standardized mean differences [SMD] = 0.32, 95% confidence interval [CI] = 0.02–0.61) and reduced FM (SMD = −0.30, 95% CI = −0.51 to −0.09) in postmenopausal women. Compared with placebo, physical exercise training showed an effect of decreasing FM (SMD = −0.66, 95% CI = −0.94 to −0.38) but not significant influence LBM (SMD = 1.31, 95% CI = −0.29 to 2.91). The network meta-analysis of our study showed that oral estrogen and progestogen plus exercise (OEPE) treatment might be the most effective anti-osteoporosis treatment (surface under the cumulative ranking curve 99.9) to reduce FM in postmenopausal women.

Conclusions:
anti-osteoporosis treatments, especially HRT, affect body composition. Furthermore, the combination of HRT and exercise training are the most effective treatment to reduce FM while maintaining LBM.
High expression of ANRIL correlated with the poor prognosis in patients with cancer: A meta-analysis
Authors: Liu Yun , Zhu Linqi , Zhao Wenjun , Zhou Yong , Shao Shihe 
Published: September 2022

Background:
ANRIL, also called CDKN2B antisense RNA 1, is an important genetic susceptibility locus for cardiovascular diseases and associated with numerous pathologies, including several human cancers.

Objective:
The relationship between ANRIL and the clinical outcome or prognosis of cancer patients was analyzed in this meta-analysis.

Methods:
One thousand seven hundred eight cancer patients were selected in 23 studies from 3 databases (Pubmed, Cochrane Library, and EMBASE).

Results:
A fixed-effects model indicated that the high expression of ANRIL is obviously linked to poor overall survival (OS) (Hazard ratio [HR] = 1.77, 95% confidence interval [CI] = 1.57–2.00, P < .00001); the random-effects model revealed poor disease-free survival (DFS) (HR = 1.86, 95% CI: 1.46–2.37, P < .00001). A high level of ANRIL expression was also associated with the tumor size (small vs large, odds ratio [OR] = 0.57, 95% CI: 0.39–0.83, P = .003), TNM stage (I + II vs III + IV; OR = 0.40, 95% CI: 0.24–0.69, P = .0008), and lymph node metastasis (LNM) (Yes vs No, OR = 3.66, 95% CI: 1.46–9.17, P = .006). ANRIL was not related significantly to histologic differentiation compared to poor with moderate + well; the OR value is 0.74, 95% CI: 0.26–2.12, P = .58. In addition, evidence suggested that a high level of ANRIL was positively associated with human cancer type, follow-up time, and sample size.

Conclusion:
This meta-analysis demonstrated that ANRIL may be a valuable biomarker for predicting poor prognosis in cancer patients.
SOX2 contributes to invasion and poor prognosis of gastric cancer: A meta-analysis
Authors: Tang Kaifeng , Liu Jingting , Liu Baoqing , Meng Chunyan , Liao Jianhua 
Published: September 2022

Background:
The sex-determining region Y-box 2 (SOX2) has been identified to be involved in tumor progression and prognosis in patients with gastric cancer (GC). However, its action is paradoxical. Thus, we conducted the first meta-analysis based on eligible studies to evaluate the clinical utility of SOX2 in GC only.

Methods:
A thorough electronic search was performed to collect eligible studies. The hazard ratios (HRs) or odds ratios (ORs) with 95% confidence intervals (CIs) were generated from included studies to assess the strength of the association between SOX2 and prognosis and clinicopathological characteristics in GC.

Results:
A total of 10 studies comprising 1321 patients with GC were identified for the meta-analysis. The pooled results revealed that high SOX2 expression was significantly associated with poor overall survival compared to low SOX2 expression (pooled HR = 1.485; 95% CI: 1.022–2.160; 𝑃 = .04). The statistical significance between SOX2 expression and overall survival was also established in univariate analysis (pooled HR = 1.606; 95% CI: 1.134–2.274; 𝑃 < .01), as well as recruitment time exceeding 2010 (pooled HR = 1.873; 95% CI: 1.041–3.371; 𝑃 = .04), follow-up time more than 5 years (pooled HR = 1.642; 95% CI: 1.066–2.527; 𝑃 = .02), and cutoff value of more than 5% of cells stained (pooled HR = 1.730; 95% CI: 1.162–2.577; 𝑃 < .01). Moreover, we verified that positive SOX2 expression was correlated with advanced tumor invasion depth (pooled OR = 0.494; 95% CI: 0.362–0.675; 𝑃 < .01) and positive vascular invasion (pooled OR = 1.515; 95% CI: 1.078–2.130; 𝑃 = .02).

Conclusion:
SOX2 could not only be an independent prognostic marker in GC but might also be a novel target for cancer therapy.
The race coefficient in glomerular filtration rate-estimating equations and its removal
Authors: Hsu Chi-yuan , Go Alan S. 
Published: September 2022

Purpose of review
To review new publications about the use of the race coefficient in glomerular filtration rate (GFR)-estimating equations since this topic was last reviewed a year ago in Current Opinion in Nephrology and Hypertension.

Recent findings
Accounting for race (or genetic ancestry) does improve the performance of GFR-estimating equations when serum creatinine (SCr) is used as the filtration marker but not when cystatin C is used. The National Kidney Foundation (NKF)–American Society of Nephrology (ASN) Task Force on Reassessing the Inclusion of Race in Diagnosing Kidney Disease recommended immediate adoption of a new refitted SCr-based equation without race and increased use of cystatin C. This report has created consensus but the endorsed new SCr equation without race underestimates GFR in Black Americans and overestimates GFR in non-Black Americans, which may result in diminished ability to detect racial disparities.

Summary
The approach recommended by the NKF–ASN Task Force represents a compromise attempting to balance a number of competing values, including racial justice, benefit of classifying more Black Americans as having (more severe) chronic kidney disease, accuracy compared with measured GFR, and financial cost. The full implications of adopting the race-free refitted CKD-EPI SCr equation are yet to be known.
Prenatal genetic testing 2: diagnostic tests
Authors: Jenkins Morgan , Seasely Angela R. , Subramaniam Akila 
Published: September 2022

Purpose of review
Prenatal genetic testing can be divided into two categories: screening and diagnosis. Prenatal genetic screening tests are used to assess carrier status or as a fetal risk assessment for a particular genetic disorder [1]. Prenatal genetic diagnostic testing is used to diagnose particular genetic conditions with as much certainty as possible [1,2]. This review will focus on the diagnostic side of prenatal genetic testing.

Recent findings
Next generation sequencing (NGS) has revolutionized prenatal genetic diagnostic testing. NGS methods are becoming more advanced and accurate as more genetic information is being linked to genetic conditions.

Summary
Prenatal genetic diagnostic testing involves clinicians invasively obtaining tissue via amniocentesis or chorionic villus sampling to identify if a fetus has a genetic condition. This testing has traditionally been done through fluorescence in-situ hybridization, karyotype, or chromosomal microarray analysis. However, genetic testing is in a time of rapid technologic expansion and new methods like NGS, which includes targeted gene panels, whole exome sequencing, and whole genome sequencing are being used too. In this time of growth, it is important that providers educate themselves on the research support and indication behind each type of genetic diagnostic test.
Reaffirming Adverse Events Related to Lung Cancer Survivors’ Target Therapies and Their Apparent Effects on Fear of Cancer Progression, Anxiety, and Depression
Authors: Yu Chu-Chun , Chu Chia-Yu , Lai Yeur-Hur , Hung Chia-Tai , Chan Jui-Chun , Chen Yen-Ju , Hsu Hui-Te , Lee Yun-Hsiang 
Published: September 2022

Background
Most advanced non–small-cell lung cancer (NSCLC) patients received targeted therapies of epidermal growth factor receptor tyrosine kinase inhibitors. However, few studies reported the relationships between adverse events (AEs) and psychological distress.

Objectives
The aims of this study were to (1) examine the differences in the incidence of AEs, fear of progression (FoP), anxiety, and depression among 3 generations of epidermal growth factor receptor tyrosine kinase inhibitors (first, gefitinib and erlotinib; second, afatinib; third, osimertinib) and (2) examine the difference in levels of FoP, anxiety, and depression between the presence and absence of AEs in NSCLC patients.

Methods
This study used a cross-sectional study design. Patients with NSCLC (N = 120) were recruited from a medical center in northern Taiwan. Adverse events, FoP, anxiety, and depression were assessed by questionnaires.

Results
The incidence rates of photosensitivity, mouth and throat sores, and diarrhea were significantly high in the gefitinib, erlotinib, and afatinib groups, respectively. A lesser proportion of patients experienced AEs in the osimertinib group, compared with those in the gefitinib and erlotinib, and afatinib groups. The incidence rates of FoP, anxiety, and depression were 13.8% to 26.0%, 24.1% to 40.4%, and 17.6% to 40.0%, respectively. Patients with photosensitivity, paronychia, and alopecia had significantly higher levels of FoP, anxiety, and depression.

Conclusion
This study confirmed the priorities of care among 3 generations of epidermal growth factor receptor tyrosine kinase inhibitors in NSCLC patients, using both the Common Terminology Criteria for Adverse Events (CTCAE 4.03) and PRO-CTCAE 1.0. Photosensitivity, paronychia, and alopecia were associated with higher levels of FoP, anxiety, and depression. Therefore, these AEs require further management.

Implications for Practice
Our study suggests a follow-up to address AEs and psychological distress.
Factors Affecting Family Management Among Chinese Parents of Children With Leukemia
Authors: Lin Nan , Jin Chendi , Zhu Jihua , Xu Hongzhen , Zhou Hongqin 
Published: September 2022

BackgroundEffective family management can improve the ability of children’s families to cope with the disease. However, the family management styles of children with leukemia are unknown.ObjectiveThis study used a family management style framework and structural equation model to determine the direct and indirect predictors of family management of children with leukemia.MethodsA total of 496 parents of children with leukemia completed the Family Management Measure, the Feetham Family Functioning Survey, the Social Support Rating Scale, and a demographic family information form. We used structural equation modeling to explore the direct and indirect effects of the study variables on family management styles.ResultsFamily functioning, family income, parental education level, and geographic location affect family management directly, among which family functioning has the most significant coefficient in the model (0.53). Siblings and social support can affect family management through the mediating effect of family functioning. Employment change can directly affect family management (−0.27) and indirectly affect family functioning (−0.08).ConclusionsOur results support the family management style framework. Individual and family factors such as family income, parental education level, geographic location, employment change, siblings, and social support contribute to the ease or difficulty of family management. In addition, family functioning can also mediate between contextual influences and family management styles.Implications for PracticeFamily functioning plays a vital role in relationships between contextual influences and family management. We can construct family management interventions according to family management influencing factors.
Posttraumatic Stress Disorder, Anxiety, and Depression Symptoms After Potentially Traumatic Events
Authors: Marqueses José M. S. , Sanz Jesús , García-Vera María Paz , Morán Noelia , Eisma Maarten C. 
Published: September 2022

Abstract
People exposed to potentially traumatic events (PTEs) may develop distinct symptom patterns, which may require different therapeutic approaches. We aimed to identify classes of people exposed to PTEs based on the presence of posttraumatic stress disorder (PTSD) clusters, anxiety, and depression and to explore which cognitive factors (rumination, worry, and negative cognitions) are associated with class membership. Latent class analyses were conducted to identify subgroups of 258 PTE-exposed Spanish adults. A three-class solution emerged: a resilient class with low odds of all symptoms (n = 188); a partial PTSD class, characterized by partial PTSD clusters, moderate anxiety, and low depression (n = 36); and a high symptom class, characterized by high PTSD, moderate anxiety, and low depression (n = 34). These classes related meaningfully to rumination, worry, and negative cognitions. Distinct symptom patterns of PTSD clusters, anxiety, and depression can be distinguished in people exposed to PTEs and relate to cognitive risk factors of psychopathology.
Fluid Accumulation in Mechanically Ventilated, Critically Ill Children: Retrospective Cohort Study of Prevalence and Outcome
Authors: Gelbart Ben , Serpa Neto Ary , Stephens David , Thompson Jenny , Bellomo Rinaldo , Butt Warwick , Duke Trevor 
Published: September 2022

OBJECTIVES:
To describe the prevalence, patterns, explanatory variables, and outcomes associated with fluid accumulation (FA) in mechanically ventilated children.

DESIGN:
Retrospective cohort study.

SETTING:
Tertiary PICU.

PATIENTS:
Children mechanically ventilated for greater than or equal to 24 hours.

INTERVENTIONS:
None.

MEASUREMENTS AND MAIN RESULTS:
Between July 2016 and July 2021, 1,636 children met eligibility criteria. Median age was 5.5 months (interquartile range [IQR], 0.7–46.5 mo), and congenital heart disease was the most common diagnosis. Overall, by day 7 of admission, the median maximum cumulative FA, as a percentage of estimated admission weight, was 7.5% (IQR, 3.3–15.1) occurring at a median of 4 days after admission. Overall, higher FA was associated with greater duration of mechanical ventilation (MV) (mean difference, 1.17 [95% CI, 1.13–1.22]; p < 0.001]), longer intensive care length of stay (LOS) (mean difference, 1.16 [95% CI, 1.12–1.21]; p < 0.001]), longer hospital LOS (mean difference, 1.19 [95% CI, 1.13–1.26]; p < 0.001]), and increased mortality (odds ratio, 1.31 [95% CI, 1.08–1.59]; p = 0.005). However, these associations depended on the effects of children with extreme values, and there was no increase in risk up to 20% FA, overall, in children following cardiopulmonary bypass and in children in the general ICU. When excluding children with maximum FA of >10%, there was no association with duration of MV (mean difference, 0.99 [95% CI, 0.94–1.04]; p = 0.64) and intensive care or hospital LOS (mean difference, 1.01 [95% CI, 0.96–1.06]; p = 0.70 and 1.01 [95% CI, 0.95–1.08]; 0.79, respectively) but an association with reduced mortality 0.71 (95% CI, 0.53–0.97; p = 0.03).

CONCLUSIONS:
In mechanically ventilated critically ill children, greater maximum FA was associated with longer duration of MV, intensive care LOS, hospital LOS, and mortality. However, these findings were driven by extreme values of FA of greater than 20%, and up to 10%, there was reduced mortality and no signal of harm.