bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison of different decision support software programs in perspective of potential drug–drug interactions in the oncology clinic
Authors: Bektay Muhammed Yunus , Seker Zehra , Eke Hatice Kubra , Turk Haci Mehmet , Izzettin Fikret Vehbi 
Published: June 2022

Introduction One of the most intriguing situations for healthcare providers is cancer therapy. Drug-drug interactions (DDIs) account for 20–30% of all adverse effects. Cancer patients are more likely to have potential-DDIs since they are taking other drugs with anticancer treatments to prevent the side effects of chemotherapeutic agents. The purpose of this research is to compare various decision support software (CDSS) programs in terms of potential DDIs. Methods A cross-sectional study was carried out. A clinical pharmacist assessed the treatment regimens of 231 cancer patients. pDDIs were evaluated using three sources: Lexicomp®, Medscape®, and Micromedex®. The ethical approval was given in November 2017 with decision number 21/286. Results A total of 231 participants who were receiving therapy and had a median age of 61.5 ± 9.18 years were assessed. Almost half of the patients (49%) were female, and 155 had at least one comorbidity in addition to cancer. Medscape had a substantial pDDI ratio of 7.09%, Micromedex had a ratio of 11.15%, and Lexicomp had a ratio of 19.50%. The total number of pDDIs for major/X/contraindicated were 363–2716 (1.56–11.7 pDDI/patient) for Medscape®, 60–1723 (0.26–7.4 pDDI/patient) for Micromedex, and 145–984 (0.62–2.24 pDDI/patient) for Lexicomp®. One of the most common pDDI found was diclofenac and dexamethasone. Interactions between escitalopram and granisetron were also common, and different CDSSs made different recommendations. Conclusions In this study, significant disparities in the quantity and severity of CDSS across distinct CDSS were discovered. One of the major finding of our study was suboptimal prescribing. To address this issue, regulatory organizations should establish and verify validation and reporting mechanisms.
Pharmacy practitioners’ adherence to safe-handling practices of chemotherapeutic drugs: A cross-sectional study in Saudi Arabia
Authors: Ogbaghebriel Azieb , Alshamrani Majed , Ibrahim Alnada , Al-Masaary Wed , Hakami Sarah , Alrasheed Shahad , Al-Sayed Nada 
Published: June 2022

Background Chemotherapy drug handling and occupational exposure are topics of concern for a variety of oncology health care professionals. Inappropriate handling can pose health risks to practitioners particularly, those who handle them on a daily basis. Therefore, this study aimed to assess chemotherapy handling practices among oncology pharmacists and pharmacy technicians in Saudi Arabia. Methods A cross-sectional study was conducted using an online survey with a structured pre-validated questionnaire. Data was collected from pharmacists and pharmacy technicians who handle chemotherapeutic agents in Saudi Arabia, and analyzed using descriptive and inferential statistics. Results A total of 79 oncology pharmacy practitioners responded to the survey. The majority (92.4%) had written chemotherapy guidelines at their workplaces. Almost all participants (98.7%) reported the availability of protective gloves and gowns, however, the availability of eye protection was only 57%. Most used chemotherapy-designated gloves (83.6%), and gowns (86.1%). However, 54.4% have reused disposable gowns. The extent of utilization of most protective equipment ranged from 70% (always using closed system transfer device) to 98% (always using shoe cover); while the practice of always using eye protection and face shield was only 30.4% and 38%, respectively. With regard to cleaning practice, the work area was cleaned at least once a day by 35%; monthly decontamination (77%); certification by the biomedical department every 6 months (67%) and at least yearly (95%). Accidental exposure was reported by 28%, and the most common adverse effect was skin irritation (82%). There was no workplace medical surveillance available for 50%. The majority (88.6%) received relevant training, but not periodic updates on their training (38%). The main barriers against the use of personal protective equipment were: that some personal protective equipments were not always available (38%), and personal protective equipments were too uncomfortable to use (30.4%). The demographic variables did not have a statistically significant effect ( p > 0.05) on the responses except for type of institution (workplace) on some of the cleaning practices that showed significant differences namely, the monthly decontamination and certification by the biomedical department. Conclusions Most protective equipment and chemotherapy guidelines were available, and the majority of pharmacy practitioners adhered to many aspects of chemotherapy safe-handling practices. Nevertheless, some areas such as medical surveillance programs, use of eye protection and face shields, the practice of re-using disposable gowns, some of the barriers against personal protective equipment use, and the provision of periodic training need improvement for better protection of the health care professionals.
Bacterial isolates and antimicrobial susceptibility pattern of ocular infection at a tertiary referral hospital in the South of Italy
Authors: D’Oria Francesco , Buonamassa Rosa , Rizzo Tiziana , Boscia Francesco , Alessio Giovanni , Guerriero Silvana 
Published: June 2022

Purpose The present study aimed to determine the prevalence of bacterial and fungal infections of the eye and also to assess the antibiotic susceptibility pattern of bacterial isolates at a tertiary referral eye care hospital in Bari, Italy. Methods Two hundred seventy three samples collected during a 2-year observation period. Culture, Gram's stain, potassium hydroxide mount and occasionally Giemsa staining was done for the clinical specimens. Antibiotic susceptibility testing was performed for bacterial growth. Results Out of 273 samples processed, 236 (86.4%) yielded growth: of them, 183 (77,5%) were bacterial, 26 (11%) fungal, and 23 (9,7%) specimens showed the presence of Acanthamoeba. Among bacterial infections, 99 (54.5%) bacterial isolates were Gram-positives, and 82 (44.8%) were Gram-negatives. Among Gram positives, Tigecycline showed the greatest susceptibility (93.8%), followed by Linezolid (97%) and Daptomycin (95.18%). Gram negative bacteria strains were susceptible to Imipenem (95%), Meropenem (98,5%) and Amikacin (91%) Multidrug in vitro resistance (resistance >3 classes of antibiotics) was found in 45 Gram positive (63%). and 33 Gram negative (44%). Conclusion Conjunctival specimens yielded mainly bacterial growth with Staphylococcus species being the predominant isolate followed by Pseudomonas species. Findings from the current analysis evidence a substantial level of in vitro resistance to ≥3 antibiotics.
On the grammaticality of passivization in bilingual compound verbs
Authors: Balam Osmer , Stadthagen-González Hans , Rodríguez-González Eva , Parafita Couto María del Carmen 
Published: June 2022

Objectives/research questions: We examined stative and eventive passive bilingual compound verbs (BCVs) in Spanish/English code-switching. Of particular interest to us was the availability of passivization in bilingual eventive passive hacer “do” constructions, purportedly banned in bilingual speech due to a universal syntactic restriction. Methodology: A total of 119 bilinguals from Northern Belize and 36 from Southwest United States completed a two-alternative forced-choice acceptability task and a language background questionnaire. Data and analysis: The analysis was conducted using Thurstone’s Law of Comparative Judgment. Conclusion: For stative passive BCVs, results revealed that Spanish/English bilinguals from both contexts gave the highest ratings to code-switched constructions without the light verb hacer. For eventive passive BCVs, however, Belize bilinguals gave preferential ratings to passive constructions with the light verb hacer. Conversely, US bilinguals rejected them. Notably, among Belize bilinguals, eventive passive BCVs that were rated as most acceptable were constructions with no gender agreement between the light verb and the feminine antecedent noun. Originality: This is the first cross-community analysis that investigates stative and eventive passive BCVs in Spanish/English code-switching. Implications: Our findings show that the light verb hacer is compatible with both stative and eventive passive BCVs. Crucially, context-specific linguistic norms and social factors rather than a universal syntactic restriction primarily determine the availability of passivization in eventive passive BCVs. Our theorizing of code-switching grammars, thus, necessitates careful consideration of invariant and variable production patterns that are profoundly shaped by historical and sociolinguistic conditions.
Predictors of service utilization among homeless former foster youth: Implications for intervention
Authors: Yoshioka-Maxwell Amanda 
Published: June 2022

Summary A high percentage of homeless youth have a history of foster care placement; this population faces high rates of behavioral health problems. No research has focused on the predictors of service use among homeless former foster youth. This analysis seeks to determine what foster care and homeless experiences are associated with service use among this population. Data were collected via convenience sample from 184 homeless former foster youth at a drop-in center in Hollywood, California. A series of logistic regressions were conducted for network engagement behaviors that may be impacted by foster care experiences. Knowledge from prior empirical results form the basis for this analysis. Findings Number of foster care placements and age at first foster care placement, overall time spent homeless, age at first homelessness, and being kicked out of housing as a cause of homelessness were associated with decreased service use. Time spent in foster care and homeless experiences during foster care were associated with increased service use. Application Results can be used to aid in understanding which foster care and homeless experiences aid or hinder service use. From a policy level, findings from this study can aid child welfare agencies in further understanding which foster care experiences present as risk factors after transition from care.
A Content Analysis of 100 Qualitative Health Research Articles to Examine Researcher-Participant Relationships and Implications for Data Sharing
Authors: Mozersky Jessica , Friedrich Annie B. , DuBois James M. 
Published: June 2022

We conducted a qualitative content analysis of health science literature ( N = 100) involving qualitative interviews or focus groups. Given recent data sharing mandates, our goal was to characterize the nature of relationships between the researchers and participants to inform ethical deliberations regarding qualitative data sharing and secondary analyses. Specifically, some researchers worry that data sharing might harm relationships, while others claim that data cannot be analyzed absent meaningful relationships with participants. We found little evidence of relationship building with participants. The majority of studies involve single encounters (95%), lasting less than 60 min (59%), with less than half of authors involved in primary data collection. Our findings suggest that relationships with participants might not pose a barrier to sharing some qualitative data collected in the health sciences and speak to the feasibility in principle of secondary analyses of these data.
Bedside ultrasonography prior to abdominal paracentesis is associated with low complication and high success rate: Experience in a National Health Service District General Hospital in the United Kingdom from 2013 to 2019
Authors: Droste Jan C , Riggott Christy , Maxfield Tracey , Zoltowski Anna 
Published: June 2022

Aims/Background: To analyse data from a bedside ultrasound-assisted ascites procedure service in a National Health Service District General Hospital and compare them to results of studies in the medical literature. Methods: A retrospective review of audit data collected (January 2013 to December 2019) of the practice of paracentesis in a National Health Service District General hospital. All adult patients referred to the ascites assessment service were included. Bedside ultrasound detected location and volume of ascites, if present. Abdominal wall diameters were determined in order to select the appropriate needle length for procedures. Results and scan images were recorded on a pro-forma. Patients who underwent a procedure were followed up for 7 days, with complications documented. Results: Seven hundred and two scans were performed on 282 patients – 127 (45%) male and 155 (55%) female. In 127 (18%) patients, an intervention was avoided. Five hundred forty-five (78%) patients underwent a procedure: 82 (15%) were diagnostic aspirations and 463 (85%) were therapeutic (large volume) paracentesis. Most scans were performed between 08:00–17:00. Average time from patient assessment to diagnostic aspiration was 4 hours 21 minutes. Complications included three failed procedures (0.6%) and one iatrogenic peritonitis (0.2%), but no bowel perforation, no major haemorrhage or death. Conclusion: It is possible to introduce a bedside ultrasound-assisted ascites procedure service to a National Health Service District General Hospital with a high success and low complication rate.
Long-term outcomes after extension block pinning for fracture-dislocations of the proximal interphalangeal joint
Authors: Nordback Panu H. , Westman Marjut , Waris Eero 
Published: June 2022

The long-term outcomes of extension block pinning used to treat unstable dorsal fracture-dislocations of the proximal interphalangeal joint have been investigated in a single centre. Thirty-one patients (33 fingers) had a clinical and radiological assessment at a mean follow-up of 16 years. Excluding one joint salvaged with an arthrodesis, the mean active range of motion of the joints was 80° with a mean 5° extension deficit. The mean active range of motion of the distal interphalangeal joint was 64°. The mean Patient-Rated Wrist and Hand Evaluation score was 6, indicating, minimal disability. The mean numeric rating scale for overall subjective pain on a scale of 0–10 was 1 and was not associated with the active range of movement. The Kallman osteoarthritis score and the range of movement of the proximal interphalangeal joint had a negative association. The long-term outcomes were satisfactory and similar to the mid-term follow-up results of the same patient cohort reported 11 years earlier. Level of evidence IV
Critical Care Nurses’ Experiences Caring for Patients When Relatives Were not Allowed in the ICUs due to COVID-19 Pandemic
Authors: Stenman Lina , Högberg Lisa , Engström Åsa 
Published: June 2022

Introduction Health care workers faced new challenges during the COVID-19 pandemic when physical contact with relatives more or less disappeared. Objectives The aim of this study is to describe the experiences of critical care nurses (CCNs) working in intensive care units (ICUs) under the visiting restrictions imposed as a result of COVID-19. Method This study followed a qualitative design. The purposive sample included CCNs with at least 1 year of experience working in an ICU with a visiting policy affected by the pandemic. Data collection was carried out via semi-structured interviews and analyzed through a qualitative content analysis with an inductive approach. Results The study results are presented in three categories with 10 subcategories. CCNs value the presence of patients’ relatives at the bedside and described many challenges when relatives could not be present with the patient during the pandemic. Conclusion Close relatives are able to share essential information about the patients and provide much-needed emotional support to them, the relatives’ role is of central importance and CCNs value their presence in ICUs more than any positive consequences of them not being there.
Multimorbidity and mortality: A data science perspective
Authors: Siah Kien Wei , Wong Chi Heem , Gupta Jerry , Lo Andrew W 
Published: June 2022

Background With multimorbidity becoming the norm rather than the exception, the management of multiple chronic diseases is a major challenge facing healthcare systems worldwide. Methods Using a large, nationally representative database of electronic medical records from the United Kingdom spanning the years 2005–2016 and consisting over 4.5 million patients, we apply statistical methods and network analysis to identify comorbid pairs and triads of diseases and identify clusters of chronic conditions across different demographic groups. Unlike many previous studies, which generally adopt cross-sectional designs based on single snapshots of closed cohorts, we adopt a longitudinal approach to examine temporal changes in the patterns of multimorbidity. In addition, we perform survival analysis to examine the impact of multimorbidity on mortality. Results The proportion of the population with multimorbidity has increased by approximately 2.5 percentage points over the last decade, with more than 17% having at least two chronic morbidities. We find that the prevalence and the severity of multimorbidity, as quantified by the number of co-occurring chronic conditions, increase progressively with age. Stratifying by socioeconomic status, we find that people living in more deprived areas are more likely to be multimorbid compared to those living in more affluent areas at all ages. The same trend holds consistently for all years in our data. In general, hypertension, diabetes, and respiratory-related diseases demonstrate high in-degree centrality and eigencentrality, while cardiac disorders show high out-degree centrality. Conclusions We use data-driven methods to characterize multimorbidity patterns in different demographic groups and their evolution over the past decade. In addition to a number of strongly associated comorbid pairs (e.g., cardiac-vascular and cardiac-metabolic disorders), we identify three principal clusters: a respiratory cluster, a cardiovascular cluster, and a mixed cardiovascular-renal-metabolic cluster. These are supported by established pathophysiological mechanisms and shared risk factors, and largely confirm and expand on the results of existing studies in the medical literature. Our findings contribute to a more quantitative understanding of the epidemiology of multimorbidity, an important pre-requisite for developing more effective medical care and policy for multimorbid patients.
Leveraging transcriptome and epigenome landscapes to infer regulatory networks during the onset of sexual maturation
Authors: Mohamed Amin R. , Naval-Sanchez Marina , Menzies Moira , Evans Bradley , King Harry , Reverter Antonio , Kijas James W. 
Published: June 2022

AbstractBackgroundDespite sexual development being ubiquitous to vertebrates, the molecular mechanisms underpinning this fundamental transition remain largely undocumented in many organisms. We designed a time course experiment that successfully sampled the period when Atlantic salmon commence their trajectory towards sexual maturation.ResultsThrough deep RNA sequencing, we discovered key genes and pathways associated with maturation in the pituitary-ovarian axis. Analyzing DNA methylomes revealed a bias towards hypermethylation in ovary that implicated maturation-related genes. Co-analysis of DNA methylome and gene expression changes revealed chromatin remodeling genes and key transcription factors were both significantly hypermethylated and upregulated in the ovary during the onset of maturation. We also observed changes in chromatin state landscapes that were strongly correlated with fundamental remodeling of gene expression in liver. Finally, a multiomic integrated analysis revealed regulatory networks and identified hub genes includingTRIM25gene (encoding the estrogen-responsive finger protein) as a putative key regulator in the pituitary that underwent a 60-fold change in connectivity during the transition to maturation.ConclusionThe study successfully documented transcriptome and epigenome changes that involved key genes and pathways acting in the pituitary – ovarian axis. Using a Systems Biology approach, we identified hub genes and their associated networks deemed crucial for onset of maturation. The results provide a comprehensive view of the spatiotemporal changes involved in a complex trait and opens the door to future efforts aiming to manipulate puberty in an economically important aquaculture species.
Evolution and functional diversification of catalase genes in the green lineage
Authors: Pan Luzhao , Luo Yin , Wang Jin , Li Xiumin , Tang Bingqian , Yang Huiping , Hou Xilin , Liu Feng , Zou Xuexiao 
Published: June 2022

AbstractBackgroundCatalases (CATs) break down hydrogen peroxide into water and oxygen to prevent cellular oxidative damage, and play key roles in the development, biotic and abiotic stresses of plants. However, the evolutionary relationships of the plant CAT gene family have not been systematically reported.ResultsHere, we conducted genome-wide comparative, phylogenetic, and structural analyses ofCATorthologs from 29 out of 31 representative green lineage species to characterize the evolution and functional diversity of CATs. We found thatCATgenes in land plants were derived from core chlorophytes and detected a lineage-specific loss ofCATgenes in Fabaceae, suggesting that theCATgenes in this group possess divergent functions. AllCATgenes were split into three major groups (group α, β1, and β2) based on the phylogeny.CATgenes were transferred from bacteria to core chlorophytes and charophytes by lateral gene transfer, and this led to the independent evolution of two types ofCATgenes: α and β types. Ten common motifs were detected in both α and β groups, and βCATgenes had five unique motifs, respectively. The findings of our study are inconsistent with two previous hypotheses proposing that (i) newCATgenes are acquired through intron loss and that (ii) the Cys-343 residue is highly conserved in plants. We found that newCATgenes in most higher plants were produced through intron acquisition and that the Cys-343 residue was only present in monocots, Brassicaceae andPp_CatX7inP. patens, which indicates the functional specificity of theCATsin these three lineages. Finally, our finding thatCATgenes show high overall sequence identity but that individualCATgenes showed developmental stage and organ-specific expression patterns suggests thatCATgenes have functionally diverged independently.ConclusionsOverall, our analyses of theCATgene family provide new insights into their evolution and functional diversification in green lineage species.