bluuebunny/crossref_metadata_2025_split huggingface dataset:
Synthesis of cinnamils and quinoxalines and their biological evaluation as anticancer agents
Authors: Wang Ruei‐Yu , Li Cai‐Wei , Cho Shu‐Tse , Chang Chun‐Hao , Chen Jih‐Jung , Shih Tzenge‐Lien 
Published: February 2022

AbstractWe synthesized multiple cinnamils and quinoxalines to evaluate their anticancer activity. Cinnamils were used as precursors for quinoxalines via condensation with 1,2‐diaminobenzene. Among the 26 synthesized compounds reported in this article, we found that cinnamil 3l exhibited its inhibitory effect with an IC50 value of 1.45 ± 0.98 μM, significantly higher than doxorubicin (8.5 ± 0.85 μM) against pancreatic cancer cells (PANC‐1). Additionally, cinnamil 3l (IC50 10.98 ± 3.63 μM) showed less cytotoxicity than doxorubicin to Hs68 cells (0.92 ± 1.11 μM). The colony formation assay demonstrated that 3l obviously decreased the PANC‐1 cell viability, and Western blot assays confirmed that 3l markedly induced apoptosis of PANC‐1 cells through Bax, Bcl‐2, and caspase 3 signaling cascades. These results demonstrate that cinnamil 3l has great potential to be further developed as a promising chemotherapeutic agent for pancreatic cancer.
Recent Advances in the Fluorescent Probes for Flavinase Activity: Design and Applications
Authors: Yang Yiting , Zhai Hongchen , Yuan Jie , Wang Kui , Zhang Hua 
Published: February 2022

AbstractFlavinases, including monoamine oxidase (MAO‐A/MAO‐B), quinone oxidoreductase (NQO1), thioredoxin reductase (TrxR), nitroreductase (NTR) and so on, are important redox enzymes in organisms. They are considered as biomarkers of cell energy metabolism and cell vitality. Importantly, their aberrant expression is related to various disease processes. Therefore, the accurate measurement of flavinase is useful for the early diagnosis of diseases, which has aroused great concern in the scientific community. Various methods are also available for the detection of flavinases, fluorescence probes are considered to be one of the best detection methods due to their easy and accurate sensing capability. This review aims to introduce the advances in the design and application of flavinase probes in the last five years. This study focuses on analyzing the design strategies and reaction mechanisms of flavinases fluorescent probes and discusses the current challenges, which will further advance the development of diagnostic and therapeutic approaches for flavinase‐related diseases.
Hydrometrocolpos and postaxial polydactyly in a girl newborn: A case report
Authors: Day Morgan L. , Avila Crystal C. , Novak Dawn L. 
Published: February 2022

AbstractThis case report is of a 35‐week female neonate with a cystic abdominal mass. Physical examination was notable for post‐axial polydactyly, distended abdomen, and abnormal urethral opening. Differential diagnosis includes Bardet–Biedl Syndrome (BBS), an autosomal recessive ciliopathy. Genetic panel revealed she was a carrier for a BBS mutation.
Retinal hemorrhage of late post‐COVID‐19 and post‐vaccine‐related pathogenic mechanisms: A new challenge for ophthalmologist in COVID era
Authors: Amin Mohammad Ashraful , Nahin Sabrina , Dola Taslima Ahmed , Afrin Sadia , Hawlader Mohammad Delwer Hossain 
Published: February 2022

AbstractCOVID‐19 infection results in extensive organ dysfunction. Thrombotic problems linked to COVID‐19 disease are common and can affect the retina. We will report a case of retina hemorrhage with possibility of linkage between COVID‐19 infection and immunization to determine whether these abnormalities are causal or coincidental.
Pool Boiling Heat Transfer on a Micro‐Structured Copper Oxide Surface with Varying Wettability
Authors: Sen Pulak , Kalita Sanjib , Sen Dipak , Das Sudev , Das Ajoy Kumar 
Published: February 2022

AbstractCopper surface is modified to copper oxide surface for high heat flux electronics applications. Copper oxide surface is prepared by chemical etching using NaOH and (NH4)2S2O8. A pool boiling experiment is conducted to investigate the critical heat flux (CHF) and boiling heat transfer coefficient (BHTC). The results indicate that BHTC of all copper oxide surfaces are enhanced remarkably. Bubble dynamics are also analyzed by means of a high‐speed camera. Bubble visualization demonstrates that the active nucleation sites for the copper oxide surfaces are higher than the bare copper surface.
Highly Sensitive “Off/On” EPR Probes to Monitor Enzymatic Activity
Authors: Elkhanoufi Sabrina , Stefania Rachele , Alberti Diego , Baroni Simona , Aime Silvio , Geninatti Crich Simonetta 
Published: February 2022

AbstractThe assessment of unregulated level of enzyme activity is a crucial parameter for early diagnoses in a wide range of pathologies. In this study, we propose the use of electron paramagnetic resonance (EPR) as an easy method to probe carboxylesterase (CE) enzymatic activity in vitro. For this application, were synthesized two amphiphilic, nitroxide containing esters, namely Tempo‐C12 (T‐C12) and Tempo‐2‐C12 (T‐2‐C12). They exhibit low solubility in water and form stable micelles in which the radicals are EPR almost silent, but the hydrolysis of the ester bond yields narrows and intense EPR signals. The intensity of the EPR signals is proportional to the enzymatic activity. CEs1, CEs2 and esterase from porcine liver (PLE) were investigated. The obtained results show that T‐C12 and T‐2‐C12‐containing systems display a much higher selectivity toward the CEs2, with a Limit of Detection of the same order of those ones obtained with optical methods.
Immobilization of 3,5‐dimethylphenyl carbamate of cellulose and amylose on silica by photochemical and thermal radical processes
Authors: Francotte Eric , Huynh Dan 
Published: February 2022

AbstractThe immobilization of cellulose 3,5‐dimethylphenyl carbamate and amylose 3,5‐dimethylphenyl carbamate on silica gel carrier was achieved by using photochemical and thermal processes. Both approaches provide an easy access to materials which were applied as chiral stationary phases (CSPs) for the chromatographic resolution of racemic molecules.The influence of parameters such as irradiation time and solvent on immobilization effectiveness was investigated. For the thermal processes, azo‐bis‐isobutyrontrile and di‐tert‐butyl peroxide were evaluated as radical initiators. The influence of parameters such as amount of radical initiator, solvent, temperature, and further handling operations on the immobilization rate was examined. The chiral recognition ability and the overall performance of the prepared immobilized phases were evaluated by injection of a series of racemic compounds onto packed HPLC columns. As there is almost no limitation of organic solvent types that can be used as mobile phases with the immobilized CSPs, they can be applied under chromatographic conditions which are prohibited with the corresponding non‐bonded CSPs. This extended applicability considerably broadens the options for improving enantioselectivity and resolving chiral compounds which are not or only poorly soluble in the conventional mobile phases.
The ethical challenges of artificial intelligence‐driven digital pathology
Authors: McKay Francis , Williams Bethany J , Prestwich Graham , Bansal Daljeet , Hallowell Nina , Treanor Darren 
Published: February 2022

AbstractDigital pathology – the digitalisation of clinical histopathology services through the scanning and storage of pathology slides – has opened up new possibilities for health care in recent years, particularly in the opportunities it brings for artificial intelligence (AI)‐driven research. Recognising, however, that there is little scholarly debate on the ethics of digital pathology when used for AI research, this paper summarises what it sees as four key ethical issues to consider when deploying AI infrastructures in pathology, namely, privacy, choice, equity, and trust. The themes are inspired from the authors' experience grappling with the challenge of deploying an ethical digital pathology infrastructure to support AI research as part of the National Pathology Imaging Cooperative (NPIC), a collaborative of universities, hospital trusts, and industry partners largely located across the North of England. Though focusing on the UK case, internationally, few pathology departments have gone fully digital, and so the themes developed here offer a heuristic for ethical reflection for other departments currently making a similar transition or planning to do so in the future. We conclude by promoting the need for robust public governance mechanisms in AI‐driven digital pathology.
Ionothermal Synthesis of Carbon/TiO2 Nanocomposite for Supercapacitors
Authors: Tao Runming , Wang Tao , Fan Juntian , Meyer Harry M. , Borisevich Albina Y. , Do‐Thanh Chi‐Linh , Dai Sheng 
Published: February 2022

AbstractA facile in‐situ ionothermal strategy is designed to synthesize carbon/oxide composites with nanoporous structure. Ionic liquids play key roles in this ionothermal method as the solvents, porous structure directing templates and carbon sources. The interaction between ionic liquids and oxides greatly improves the carbon yield of ionic liquids from nearly 0 to 18 wt.%. With the synergistic effects of the high electrical conductivity of the nitrogen‐rich carbon species and the Ti3+ self‐doping enhanced electrical conductivity of TiO2, C/TiO2‐4 composite exhibits better electrochemical performance than C/SiO2 and C/Nb2O5 do as a supercapacitor electrode material, delivering a high specific capacitance of 152.4 F g−1 at 5 mV s−1 with good capacitance retentions of 84.7%, 72.2% and 46.0% at 30, 100 and 500 mV s−1, respectively.
Creating Ion Channel Kinetic Models Using Cloud Computing
Authors: Mangold Kathryn E. , Zhou Zhuodong , Schoening Max , Moreno Jonathan D. , Silva Jonathan R. 
Published: February 2022

AbstractComputational modeling of ion channels provides key insight into experimental electrophysiology results and can be used to connect channel dynamics to emergent phenomena observed at the tissue and organ levels. However, creation of these models requires substantial mathematical and computational background. This tutorial seeks to lower the barrier to creating these models by providing an automated pipeline for creating Markov models of an ion channel kinetics dataset. We start by detailing how to encode sample voltage‐clamp protocols and experimental data into the program and its implementation in a cloud computing environment. We guide the reader on how to build a containerized instance, push the machine image, and finally run the routine on cluster nodes. While providing open‐source code has become more standard in computational studies, this tutorial provides unprecedented detail on the use of the program and the creation of channel models, starting from inputting the raw experimental data. © 2022 Wiley Periodicals LLC.Basic Protocol: Creation of ion channel kinetic models with a cloud computing environmentAlternate Protocol: Instructions for use in a standard high‐performance compute cluster
Application of information communication network security management and control based on big data technology
Authors: Du Meiyan 
Published: February 2022

SummaryWith the continuous development of communication technology and computer network technology and the continuous progress of social economy, information technology has penetrated into all aspects of people's lives. The basic task of communication network is to ensure the reliability and security of information transmission. Based on the above background, the purpose of this study is to study the application of information communication network security management and control based on big data technology. Based on the concept and management and control structure of information communication network, combined with the data collection and preprocessing in big data technology, this study analyzes the feasibility of big data technology applied in communication network management and control and expounds the specific application of big data technology from the four aspects of troubleshooting, security protection, business management, and resource allocation. At last, the test environment of information communication network security management and control platform based on big data technology is built in the laboratory to test the network management performance and routing transmission performance of the system. The experimental results show that the communication success rate of the information communication network security management and control platform based on big data technology remains to 91.78%. It can be seen from the test results that the information communication network security management and control platform based on big data technology can not only accurately collect sensor data but also have the function of real‐time monitoring network status and reconfiguration of nodes.
Research on the method of network space security countermeasure drill
Authors: Wang Shaoqiang 
Published: February 2022

SummaryWith the increasingly severe form of cyberspace confrontation, cyberspace security has been paid more and more attention by all countries in the world and presents the development trend from feature‐based “identity recognition” to identity‐based “identity recognition.” Through the research of cyberspace security development, machine learning, and cyberspace security confrontation drill method, the feasibility of dual role multilevel confrontation method is demonstrated. In this paper, a preliminary scheme of applying machine learning to cyberspace security is proposed, and the concrete implementation of dual role multilevel confrontation method for cyberspace security and the specific application of machine learning in cyberspace security are given. It improves the security and credibility of cyberspace itself and improves the ability of cyberspace to resist attacks.
Partner Support and Goal Outcomes: A Multilevel Meta‐Analysis and a Methodological Critique
Authors: Vowels Laura M. , Carnelley Katherine B. 
Published: February 2022

AbstractIn the meta‐analysis, we combined evidence across studies from different theoretical perspectives addressing the association between partner support (responsive, practical and negative support) and goal outcomes (self‐efficacy, commitment and progress). The sample included 195 effect sizes from 36 samples with 10,130 participants in romantic relationships. The results were analysed using a random‐effects multilevel model and the overall effect size was r = .25. This effect size is comparable to strong individual predictors of goal outcomes (e.g. high intention to achieve a goal) highlighting the importance of close relationships in goal pursuit. In line with the theory of thriving through relationships, the findings suggested that both responsiveness (r = .27) and practical (r = .22) support are helpful for goal outcomes whereas negative (r = −.14) support can hinder goal pursuit. Existing studies have strong methods but lack validated measures. Results have implications for areas including changing health behaviours and improving occupational, educational and therapy outcomes.
Enhancement of chromium contaminated soil remediation by ferrous sulfate with the addition of biogas residue
Authors: Gao Ying , Zhao Fengbin , Zhao Yuhao , Sun Yingjie , Zhang Dalei , Yuan Liqun , Fang Xin 
Published: February 2022

AbstractIn this study, a cost‐effective and eco‐friendly method was developed to remediate soil contaminated by hexavalent chromium (Cr[VI]) using ferrous sulfate and biogas residue (BR). The results show that the addition of BR at mole ratio of Fe(II)/Cr(VI) = 3:1 and mass ratio of BR (dry mass)/Cr(VI) = 70:1 significantly improved the reduction of Cr(VI) and reduced its mobility. Moreover, the reduction efficiency of Cr(VI) was higher than 85% at day 1 and reached a maximum of 96.7% at day 7. The X‐ray photoelectron spectroscopy, scanning electron microscopy, and microbial diversity analyses indicated that the microbial mechanism created by the BR addition was crucial for the long‐term and stable reduction of Cr(VI). The enriched Cr(VI)‐reducing bacteria genera in the BR directly reduced Cr(VI), whereas the reducing bacteria in the BR indirectly reduced Cr(VI) to Cr(III) through the electron transport system in the reaction system. The addition of BR can lead to a high reduction efficiency and long‐term stabilization of Cr(VI)‐contaminated soils. This study provides reference values for the combined remediation technology for Cr(VI)‐contaminated soils.
Teilströme als geothermisches Potential bei tiefliegenden Tunneln
Authors: Burger Ulrich , Geisler Thomas , Lehner Florian , Cordes Tobias , Marcher Thomas 
Published: February 2022

AbstractDeep tunnels are long tunnel systems which cross different hydrogeological environments as a drainage. Thus, their water inflows have very different characteristics. The tunnel water discharges formed from these water inflows, which drain individual sections of the tunnel system, also have different properties. These discharges from individual tunnel sections – so‐called sectional discharges – are important for determining the geothermal potential of deep tunnels. Knowledge of the origins of sectional discharges and their properties allows optimising the usage of the geothermal potential of the water by provision of adequate tunnel water management. By monitoring sectional discharges, the most effective ”mixing scenarios“ can be calculated and thus an optimization of the geothermal output can be achieved. The concept of sectional discharges for the geothermal evaluation of deep tunnels is presented based on data from the Brenner Base Tunnel (BBT).
Development of second primary malignancies after transoral surgery in human papilloma virus‐positive oropharyngeal squamous cell carcinoma
Authors: Stepan Katelyn , Craig Ethan , Skillington Scott Andrew , Deutsch Brian C. , Chen Stephanie , Wamkpah Nneoma S. , Bollig Craig A. , Kallogjeri Dorina , Thorstad Wade L. , Puram Sidharth V. , Pipkorn Patrik , Jackson Ryan S. 
Published: February 2022

AbstractBackgroundLittle data exists regarding the incidence of oropharyngeal and upper aerodigestive tract (UADT) second primary malignancies (SPM) among human papilloma virus (HPV)‐positive oropharyngeal squamous cell carcinoma (OPSCC). Here we evaluate SPM rates among patients with HPV‐related OPSCC.MethodsA retrospective cohort study of 412 patients with HPV‐related OPSCC who underwent transoral resection +/− adjuvant therapy at a single center between 1996 and 2018.ResultsTwenty patients (4.9%) developed SPM of the UADT, nine (2.2%) occurring in the oropharynx. Median time to diagnosis was 59.5 months (0–173 months). Risk of SPM was lower for patients receiving adjuvant radiation (aHR: 0.25, 95%CI: 0.08–0.78). There was no difference in overall or disease‐free survival between those with and without SPM.ConclusionThe rate of SPM among patients with HPV‐positive OPSCC is lower than reported rates among HPV‐negative OPSCC. To date, this is the largest study evaluating SPM in patients with surgically treated HPV‐positive OPSCC.
Single‐atom catalysts supported on ordered porous materials: Synthetic strategies and applications
Authors: Xue Kaiwen , Mo Yan , Long Baojun , Wei Wen , Shan Changsheng , Guo Shaojun , Niu Li 
Published: February 2022

AbstractSingle‐atom catalysts (SACs) are attracting extensive attention due to their incredibly catalytic activity and selectivity, high utilization of metal atoms, and obvious cost reduction. The unique ordered porous materials (OPMs) are promising carriers for stabilizing single atoms due to their large surface areas and uniformly tunable pore sizes. Meantime, the geometric and electronic structures of single‐atom metals can be tuned by the interaction between the single‐atoms (SAs) and OPMs to enhance the catalytic activity of SACs. The SACs based on OPMs, such as zeolites, metal–organic frameworks, and ordered mesoporous materials, have been developing fast recently. Herein, we review recent advancements on structural feature, synthetic strategy, characterization technique, and catalytic applications of OPMs‐based SACs. The opportunities and challenges about SAs/OPMs are also provided to develop the novel catalysts with superior catalytic performances in the future.image
Should we still be doing ICT4D research?
Authors: Masiero Silvia 
Published: February 2022

AbstractIn over 30 years of history, the field of Information and Communication Technology for Development (ICT4D) has asserted itself both within Information Systems (IS) and across disciplines. However, the core assumptions on which the field was built have been questioned over time, resulting in a situation in which such assumptions—on development, the role of ICTs towards it, and the meaningfulness of the term “developing countries”—have been problematized. As a result, this paper poses the question on whether it still makes sense to do ICT4D research: starting from older ICT4D landscape papers, it fleshes out three main assumptions made at the origins of the field. It then problematizes such assumptions through more recent works, noting that the old theoretical grounds of the field do not apply anymore today. Having said that, it states three reasons for renewed ICT4D research efforts: the reframing of “development” in terms of justice, the potential of multitheoretical research approaches, and the turn to indigenous understandings of ICTs. For all these reasons, it concludes that doing ICT4D research is especially important today, in virtue of a juncture of history that problematizes its older assumptions.
“Honestly, I Had a Very Strong Reaction to this Reading”: Social Studies Pre‐Service Teachers’ Application of Literacy Frameworks While Engaging with a Graphic Textbook
Authors: Mathews Sarah A. , McGill Craig M. 
Published: February 2022

AbstractBecause social studies educators are expected to incorporate literacy into their instruction, it is important to consider how prospective teachers interact with literacy frameworks as they engage with social studies content. This qualitative case study examines two pre‐service social studies teachers enrolled in a teacher preparation course at a Hispanic‐Serving Institution as they read and reacted to Zinn's (2008) graphic textbook,A People's History of the American Empire. The study examines how these pre‐service teachers employed three literacy frameworks—disciplinary, critical, and racial literacy—when reading social studies material. Data sources included student‐produced written responses, researcher’s field notes from whole‐class discussions, and semi‐structured interviews. Findings demonstrate how readers sometimes use parts of frameworks, entire frameworks in isolation, and multiple frameworks simultaneously. Neither participant addressed the socio‐emotional aspect of racial literacy. This study suggests how teacher educators can better prepare social studies teachers to incorporate literacy while using graphic texts.