bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of microscopic incomplete resection for colorectal liver metastases on surgical margin recurrence: R1‐Contact vs R1 < 1 mm margin width
Authors: Ausania Fabio , Landi Filippo , Martínez‐Pérez Aleix , Sandomenico Raffaele , Cuatrecasas Miriam , Pages Mario , Maurel Joan , Garcia Rocio , Fuster Josep , Garcia‐Valdecasas Juan Carlos 
Published: January 2022

AbstractBackgroundSeveral studies highlighted an inferior outcome of R1 resection for colorectal cancer liver metastases (CRLM); it is still unclear whether directly involved margins (R1‐contact) are associated with a poorer outcome compared to R1 < 1 mm. The aim of this study is to analyze the impact on surgical margin recurrence (SMR) of R1‐contact vs R1 < 1 mm patients.MethodsPatients who underwent surgery for CRLM between 2009‐2018 with both R1 resections on final histology were included and compared in terms of recurrence and survival. Factors associated with SMR were assessed by univariate and multivariate analysis.ResultsOut of 477, 77 (17.2%) patients showed R1 resection (53 R1‐Contact and 24 R1 < 1 mm). Overall recurrence rate was 79.2% (R1 < 1 mm = 70.8% vs R1‐contact group = 83%,P = .222). Median disease‐free survival (DFS) and disease‐specific survival (DSS) were significantly higher in R1 < 1 mm vs R1‐contact group (93 vs 55 months;P = .025 and 69 vs 46 months;P = .038, respectively). The SMR rate was higher in R1‐contact compared to R1 < 1 mm group (30.2% vs 8.3%;P = .036). At univariate analysis, age, number of metastases, open surgical approach, RAS status, and R1‐contact were associated with SMR. At multivariate analysis, R1‐contact margin was the only factor independently associated with higher SMR (OR = 5.6;P = .046).ConclusionsR1‐contact margin is independently associated with SMR after liver resection for CRLM. Patients with R1‐contact margin will also experience poorer DFS and DSS.
Dysfunctional career thoughts, profile elevation, and RIASEC skills of career counseling clients
Authors: Kronholz Julia , Osborn Debra S. 
Published: January 2022

AbstractEighty‐six individuals seeking counseling at a university career center completed the Career Thoughts Inventory and the Self‐Directed Search, 5th Edition, agreeing to participate in the present study exploring relationships among dysfunctional career thoughts (DCTs), profile elevation, and RIASEC skills. Multiple regression analyses indicated that DCTs captured 16% of variance in profile elevation and 16% of variance in RIASEC skills. Seven percent of the variance in DCTs were predicted by RIASEC skills and profile elevation. A discussion includes examination of results and limitations, as well as implications for theory, research, and practice.
Osteochondroma formation is independent of heparanase expression as revealed in a mouse model of hereditary multiple exostoses
Authors: Mundy Christina , Chung Juliet , Koyama Eiki , Bunting Stuart , Mahimkar Rajeev , Pacifici Maurizio 
Published: January 2022

AbstractHereditary multiple exostoses (HME) is a rare, pediatric disorder characterized by osteochondromas that form along growth plates and provoke significant musculoskeletal problems. HME is caused by mutations in heparan sulfate (HS)‐synthesizing enzymes EXT1 or EXT2. Seemingly paradoxically, osteochondromas were found to contain excessive extracellular heparanase (Hpse) that could further reduce HS levels and exacerbate pathogenesis. To test Hpse roles, we asked whether its ablation would protect against osteochondroma formation in a conditional HME model consisting of mice bearing floxed Ext1 alleles in Agr‐CreER background (Ext1f/f;Agr‐CreER mice). Mice were crossed with a new global Hpse‐null (Hpse−/−) mice to produce compound Hpse−/−;Ext1f/f;Agr‐CreER mice. Tamoxifen injection of standard juvenile Ext1f/f;Agr‐CreER mice elicited stochastic Ext1 ablation in growth plate and perichondrium, followed by osteochondroma formation, as revealed by microcomputed tomography and histochemistry. When we examined companion conditional Ext1‐deficient mice lacking Hpse also, we detected no major decreases in osteochondroma number, skeletal distribution, and overall structure by the analytical criteria above. The Ext1 mutants used here closely mimic human HME pathogenesis, but have not been previously tested for responsiveness to treatments. To exclude some innate therapeutic resistance in this stochastic model, tamoxifen‐injected Ext1f/f;Agr‐CreER mice were administered daily doses of the retinoid Palovarotene, previously shown to prevent ectopic cartilage and bone formation in other mouse disease models. This treatment did inhibit osteochondroma formation compared with vehicle‐treated mice. Our data indicate that heparanase is not a major factor in osteochondroma initiation and accumulation in mice. Possible roles of heparanase upregulation in disease severity in patients are discussed.
Ground truth validated 3D electrical resistivity imaging of the archaeological deposits at Arma Veirana cave (northern Italy)
Authors: Torrese P. , Zucca F. , Martini S. , Benazzi S. , Drohobytsky D. , Gravel‐Miguel C. , Hodgkins J. , Meyer D. , Miller C. , Peresani M. , Orr C. , Riel‐Salvatore J. , Strait D. S. , Negrino F. 
Published: January 2022

ABSTRACTWe present 3D electrical resistivity tomography (ERT) imaging of the archaeological deposits at Arma Veirana cave (northern Italy), to date only partially explored. The archaeological importance of the cave is due to the presence of a rich Mousterian layer, traces of Late Upper Palaeolithic (Epigravettian) temporary occupations and an Early Mesolithic burial of a female newborn. ERT is rarely employed in Palaeolithic cave contexts because Palaeolithic remains are typically disseminated in loose deposits and either do not possess high electrical resistivity contrasts or are too small to be detected. Furthermore, some issues can derive from the confined environment in caves. In this view, our study represents an opportunity to assess the capability of this geophysical method to retrieve subsurface information of Palaeolithic cave deposits and create a framework for the improvement of ERT applications in such a peculiar cave context. The aim of this study was to define the features of the deposits (i.e. geometry, thickness and sediment distribution) and to map the morphology of the underlying bedrock. Results reveal that the thickness of the deposits varies both along the primary axis of the cave and transverse to it. This study allowed the recognition of shallow, meter‐sized, fine‐grained sediment‐filled structures with a longitudinal orientation with respect to the primary axis of the cave, as well as a possible erosional‐like structure. The cross‐validation of geophysical results with the archaeological evidence (the Early Mesolithic newborn burial and Epigravettian artefacts) confirms that the low‐resistivity unit could be the most promising from an archaeological point of view.
Residue degradation, transfer and risk assessment of pyriproxyfen and its metabolites from tea garden to cup by ultra performance liquid chromatography tandem mass spectrometry
Authors: Li Hongxia , Zhong Qing , Wang Min , Luo Fengjian , Wang Xinru , Zhou Li , Zhang Xinzhong 
Published: January 2022

AbstractBACKGROUNDTea is one of the most popular drinks in the world. The growth of tea plant is inseparable from the control of pesticides on diseases and pests. Pyriproxyfen is used as a pesticide substitute to control insect pests in tea gardens, but little is known about its residue degradation. Here, we performed an integrative study of the degradation and metabolism of pyriproxyfen from the tea garden to the cup.RESULTSThe dissipation half‐life of pyriproxyfen during tea growth was 2.74 days, and five metabolites PYPAC, PYPA, DPH‐Pyr, 5′′‐OH‐Pyr, and 4′‐OH‐Pyr were generated. The total processing factors for pyriproxyfen in green tea and black tea were 2.41–2.83 and 2.77–3.70, respectively. The residues of pyriproxyfen and its metabolites were affected by different processing steps. The total leaching rates of pyriproxyfen from green tea and black tea into their infusions were 9.8–12.3% and 5.3–13.8%, respectively. The leaching rates of the five metabolites were higher than that of pyriproxyfen and increased the intake risk.CONCLUSIONTo ensure safe consumption, the recommended maximum residue limit value of pyriproxyfen in tea can be set to 5 mg kg−1 and the pre‐harvest interval can be set to 5 days. © 2022 Society of Chemical Industry.
Distributed real‐time rendering for ultrahigh‐resolution multiscreen 3D display
Authors: Chen Yingying , Sang Xinzhu , Li Yuanhang , Xing Shujun , Guan Yanxin , Yan Binbin , Wang Kuiru 
Published: January 2022

AbstractLarge‐scale autostereoscopic three‐dimensional (3D) displays can give audiences a truly immersive feeling with strong visual impact. However, the traditional autostereoscopic 3D display systems are limited by the display hardware, making it difficult to directly achieve large‐scale 3D displays with high resolution. Multiscreen splicing with laser backlights can be used for large‐scale and ultrahigh‐resolution 3D display, but it normally results in subscreen image asynchronization, view zone error, or obvious edge overlapping. To solve the problems mentioned above, a distributed real‐time rendering system for ultrahigh‐resolution multiscreen 3D display is proposed. Fifteen 3D LCD display devices are driven through a host, cooperating with laser backlights, a lenticular lens array (LLA), and a directional diffuser to display high resolution, high frame rate, large size, and wide‐viewing angle 3D images. The resolution of the whole display system can reach 23,040 × 21,600. The rendering system provides a large‐scale and real‐time 3D scene image with an ultrahigh‐definition resolution at a speed of 40 frames per second and high quality.
Injectable decellularized nucleus pulposus tissue exhibits neuroinhibitory properties
Authors: Piening Logan M. , Lillyman David J. , Lee Fei San , Lozano Alvaro Moreno , Miles Jeremy R. , Wachs Rebecca A. 
Published: January 2022

AbstractBackgroundChronic low back pain (LBP) is a leading cause of disability, but treatments for LBP are limited. Degeneration of the intervertebral disc due to loss of neuroinhibitory sulfated glycosaminoglycans (sGAGs) allows nerves from dorsal root ganglia to grow into the core of the disc. Treatment with a decellularized tissue hydrogel that contains sGAGs may inhibit nerve growth and prevent disc‐associated LBP.MethodsA protocol to decellularize porcine nucleus pulposus (NP) was adapted from previous methods. DNA, sGAG, α‐gal antigen, and collagen content were analyzed before and after decellularization. The decellularized tissue was then enzymatically modified to be injectable and form a gel at 37°C. Following this, the mechanical properties, microstructure, cytotoxicity, and neuroinhibitory properties were analyzed.ResultsThe decellularization process removed 99% of DNA and maintained 74% of sGAGs and 154% of collagen compared to the controls NPs. Rheology demonstrated that regelled NP exhibited properties similar to but slightly lower than collagen‐matched controls. Culture of NP cells in the regelled NP demonstrated an increase in metabolic activity and DNA content over 7 days. The collagen content of the regelled NP stayed relatively constant over 7 days. Analysis of the neuroinhibitory properties demonstrated regelled NP significantly inhibited neuronal growth compared to collagen controls.ConclusionsThe decellularization process developed here for porcine NP tissue was able to remove the antigenic material while maintaining the sGAG and collagen. This decellularized tissue was then able to be modified into a thermally forming gel that maintained the viability of cells and demonstrated robust neuroinhibitory properties in vitro. This biomaterial holds promise as an NP supplement to prevent nerve growth into the native disc and NP in vivo.
Knowledge management andCOVID‐19: Technology, people and processes
Authors: Tomé Eduardo , Gromova Elizaveta , Hatch Andrew 
Published: January 2022

AbstractIn this paper, we analyse the impact of the Covid‐19 crisis in organizations from the point of view of knowledge management. Specifically, we address the question of technology, people and processes. We conclude, first, that KM should be put at the centre stage in 2021 because, above all, first and foremost, the Covid‐19 crisis is a crisis about knowledge, and that a massive knowledge failure has been at its core – namely, the absence of a vaccine and the cure for Covid‐19. We furthermore conclude that in organizations, there was a complete lack of “social knowledge” linked with “organizational behaviour” which led to an organizational crisis; quite crucially, we believe that the mentioned crisis was even fostered by the immense technology available, but continued because, despite all the value of people, there was not knowledge about processes; in fact, suddenly, the drastic change in setting caused previously competent people to become incompetent. All this leads to the third conclusion, namely, the solution of the crisis will be achieved using technology and making people competent again and teaching them the right processes. Finally, for the time being, Humanity is still searching for answers, and we believe that all the partial measures (such as use of masks, social distance, washing hands, home/remote working, etc.) will mean an advance and increase in organizational agility.
Effect of species diversity levels and microbial consortium on biomass production, net economic gain, and fertility of marginal land
Authors: Mishra Roli , Singh Rana Pratap 
Published: January 2022

AbstractIncreasing the income of crop growers per unit area and restoring the fertility of marginal soils are major challenges of agricultural sustainability in the Indian agrarian economy. This study investigates the benefits of plant communities consisting of Indian licorice (Abrus precatorius L.), stevia (Stevia rebaudiana B.), chilli (Capsicum annum L.), and a microbial consortium of four plant growth‐promoting bacteria and fungi (Bacillus pseudomycoides, Bacillus firmus, Aspergillus luchuensis, and Aspergillus tamarii) on production of plant biomass, income of growers, and its ability to improve soil fertility over a 2 year period. The three crop species were planted in all possible groupings at one, two, and three species diversity levels with three replication and two treatments, that is, with plant growth‐promoting microbes (PGPM) and without PGPM. The maximum increases in biomass (6.8 mega gram ha−1) and aboveground carbon sequestration (3.2 mega gram ha−1) were found for the three species diversity level of LSC (Indian licorice–stevia–chilli) plus PGPM. The highest belowground carbon sequestration (35 mega gram ha−1) and maximum soil fertility benefits [for example, pH (1.16‐times), electrical conductivity (7.53‐times), bulk density (1.84‐times), soil total organic carbon (3.99‐times), available nitrogen (5.95‐times), dehydrogenase (6.16‐times), microbial biomass carbon (4.06‐times), and colony‐forming units (4.44‐times)] were recorded at the two species diversity level of LC (Indian licorice‐chilli) with and without PGPM, compared with the soil properties before cultivation of these plants/additives. The highest net income (9.9 Lac ha−1 yr−2) was estimated for the two species diversity level (LS) plus addition of PGPM.
Role of soil biotic and abiotic properties in plant community composition in response to nitrogen addition
Authors: Qu Qing , Wang Minggang , Xu Hongwei , Yan Ziran , Liu Guobin , Xue Sha 
Published: January 2022

AbstractNutrient addition can alter plant–soil‐microbe interactions. However, knowledge remains limited about how the soil biotic and abiotic properties drive changes in plant community composition and diversity after nitrogen (N) addition. In this study, four N addition rates (N0, N3, N6, and N9: 0, 3, 6, and 9 g N m−2yr−1) were applied to a grassland community on the Loess Plateau (China) to evaluate the response of plant community biomass, evenness, and composition to N addition. Overall, N addition significantly increased plant shoot and root biomass by 27.75%–31.37% and 39.60%–65.42% compared with N0, but no significant difference was observed among N3, N6, and N9. N addition significantly decreased shoot/root biomass ratio by 7.17%–21.84%, and plant community evenness by 3.80%–8.80% compared with N0, particularly under N3 and N6 treatments. Furthermore, N addition enhanced the abundance of bacteria and fungi, but their composition was not altered. Responses of plant biomass and evenness to N addition were correlated to changes in NO3−‐N, soil total phosphorus, and the abundance of bacteria and fungi; additionally, the composition was primarily affected by the microbial abundance. Our research indicates that N addition can significantly alter plant community composition, particularly at low addition rates, and such alteration may be more affected by the soil microbial abundance. The findings of this study have important implications for the sustainable management of grassland ecosystems.
Regulation simulation of land‐use ecological security, based on a CA model and GIS: A case‐study in Xingguo County, China
Authors: Xie Hualin , Zhu Zhenhong , He Yafen 
Published: January 2022

AbstractEcological land is constantly modified by agriculture and construction, which leads to soil erosion, land degradation, soil pollution flood disasters, and many other land ecological security problems, threatening sustainable development. Few studies have been made to construct a land‐use ecological security pattern (LUESP) aimed at achieving urban expansion, food security, and ecological security from the perspective of land‐use needs. This study seeks to provide decision makers with the choice of multi‐scenario LUESPs by simulating the LUESP under different scenarios, offering a reasonable land‐use ecological security regulation strategy. In this paper, the ecological security evaluation method was used to identify key ecological space of a study area and the scenario analysis method was used to set up three security scenarios: ideal security (IS) scenario, satisfactory security (SS) scenario, and bottom‐line security (BS) scenario, thereby constructing the constrained cellular automata (CA) model of the LUESP and simulating the LUESPs under three security scenarios for Xingguo County, China. The results showed that the LUESP construction land index and arable land index did not exceed the total amount of the General Plan of Land Use in Xingguo County under the three security scenarios. Moreover, both key ecological space loss and landscape fragmentation degree were greatly reduced, the ecological patches tend to cluster, and the anti‐jamming ability of the landscape pattern was enhanced. The ranking of LUESPs under three security scenarios was as follows: BS scenario > SS scenario > IS scenario. These results implied that the LUESPs met the demand for land in Xingguo County for ecological security, food security, and economic development, while space occupied is different under three security scenarios. The decision makers can adopt appropriate land‐use ecological security regulation strategies according to the future development plans of the region.
Existence of solution of some p,q${p,q}$‐Laplacian system under local superlinear conditions
Authors: Cerda Patricio , Souto Marco , Ubilla Pedro 
Published: January 2022

AbstractWe study existence of positive radial solutions for the following class of quasi‐linear elliptic systems
where the nonlinearities satisfy some local superlinear property at . Here B is the unity ball in and . Some difficulties here are that this system, in general, is non‐variational and that might occur. Thus, our strategy to obtain a positive solution is through a priori bound methods. One of the important results in this article is that we obtain these estimates, assuming superlinearity hypotheses on the variables u and v at infinity just in some subset of the ball, allowing us assuming, for example, supercritical growths on outside of that subset. We also note that we can consider nonlinearities which are not necessary asymptotic to a power at and so it is not possible to use the classic Liouville type nonexistence results.
Multiple criteria decision‐making in healthcare and pharmaceutical supply chain management: A state‐of‐the‐art review and implications for future research
Authors: Laganà Iside Rita , Colapinto Cinzia 
Published: January 2022

AbstractDecisions in supply chain management (SCM) are subject to numerous conflicting criteria and multiple objectives. For such decisions, multiple criteria decision making (MCDM) methods are definitely appropriate. The implementation of the healthcare supply chain (HSC) is more complex to manage than any other supply chains, as it involves human life, causing conflicts of interest and hindering the final decision. Previous researchers suggested different SC models for healthcare products such as drugs, vaccines, and other medical equipment. This article provides an overview of published articles in the application of MCDM methods in HSCM at the strategic, tactical, and operational levels. We studied and categorized 139 articles published in 2006–2021, providing academic researchers, practitioners, and governments with insights into the application of different MCDM methods. The review allows us to establish guidelines for the selection of appropriate methods for HSC management and provide support to the management of issues in the healthcare and pharmaceutical sector.
Cardiovascular therapeutics: A new potential for anxiety treatment?
Authors: Repova Kristina , Aziriova Silvia , Krajcirovicova Kristina , Simko Fedor 
Published: January 2022

AbstractBesides the well‐recognized risk factors, novel conditions increasing cardiovascular morbidity and mortality are emerging. Undesirable emotions and behavior such as anxiety and depression, appear to participate in worsening cardiovascular pathologies. On the other hand, deteriorating conditions of the heart and vasculature result in disturbed mental and emotional health. The pathophysiological background of this bidirectional interplay could reside in an inappropriate activation of vegetative neurohormonal and other humoral systems in both cardiovascular and psychological disturbances. This results in circulus vitiosus potentiating mental and circulatory disorders. Thus, it appears to be of utmost importance to examine the alteration of emotions, cognition, and behavior in cardiovascular patients. In terms of this consideration, recognizing the potential of principal cardiovascular drugs to interact with the mental state in patients with heart or vasculature disturbances is unavoidable, to optimize their therapeutic benefit. In general, beta‐blockers, central sympatholytics, ACE inhibitors, ARBs, aldosterone receptor blockers, sacubitril/valsartan, and fibrates are considered to exert anxiolytic effect in animal experiments and clinical settings. Statins and some beta‐blockers appear to have an equivocal impact on mood and anxiety and ivabradine expressed neutral psychological impact. It seems reasonable to suppose that the knowledge of a patient's mood, cognition, and behavior, along with applying careful consideration of the choice of the particular cardiovascular drug and respecting its potential psychological benefit or harm might improve the individualized approach to the treatment of cardiovascular disorders.