bluuebunny/crossref_metadata_2025_split huggingface dataset:
Randomized, Controlled Trial of a Digital Behavioral Therapeutic Application to Improve Glycemic Control in Adults With Type 2 Diabetes
Authors: Hsia Judith , Guthrie Nicole L. , Lupinacci Paul , Gubbi Ananda , Denham Douglas , Berman Mark A. , Bonaca Marc P. 
Published: October 2022

OBJECTIVE
To evaluate the efficacy and safety of a digital therapeutic application (app) delivering cognitive behavioral therapy (CBT) designed to improve glycemic control in patients with type 2 diabetes.

RESEARCH DESIGN AND METHODS
Adults with type 2 diabetes and an HbA1c of 7 to &lt;11% were randomly assigned to receive access to a digital therapeutic app delivering CBT (BT-001) or a control app, both on top of standard of care management. CBT is an established form of psychological treatment that endeavors to identify and change unhelpful thinking patterns. The primary study end point was treatment group difference in mean HbA1c change from baseline to 90 days.

RESULTS
Among 669 randomly assigned subjects who completed app onboarding, the mean age was 58 years, BMI 35 kg/m2, 54% were female, 28% Black, and 16% Latino. Baseline HbA1c was 8.2 and 8.1% in the BT-001 and control groups, respectively. After 90 days of app access, change in HbA1c was −0.28% (95% CI −0.41, −0.15) in the BT-001 group and +0.11% (95% CI −0.02, 0.23) in the control group (treatment group difference 0.39%; P &lt; 0.0001). HbA1c reduction paralleled exposure to the therapeutic intervention, assessed as the number of modules completed on the app (P for trend &lt;0.0001). No adverse events in either group were attributed to app use and no adverse device effects reported.

CONCLUSIONS
Patients randomly assigned to the BT-001 arm relative to the control arm had significantly lower HbA1c at 90 days. The digital therapeutic may provide a scalable treatment option for patients with type 2 diabetes.
”Mä kertakaikkiaan löydän jonkun konstin, että nousen täältä” - Kroonista väsymysoireyhtymää (ME/CFS) sairastavien toimijuuden modaliteetit
Authors: Keurulainen Meeri , Holma Juha , Wallenius Elina , Pänkäläinen Mikko , Hintikka Jukka , Partinen Markku 
Published: October 2022

Krooninen väsymysoireyhtymä (ME/CFS [myalgic encephalomyelitis/ chronic fatigue syndrome]; G93.3) on pitkäkestoinen, harvinainen ja vaikeasti diagnosoitava sairaus, jolle on tyypillistä voimakas pitkäaikainen väsymys, joka ei selity millään muulla fyysisellä tai psykiatrisella sairaudella. Valtakunnalliset Hyvä käytäntö konsensussuositukset sairauden hoitoon julkaistiin helmikuussa 2021. Tässä tutkimuksessa tarkastellaan viiden kroonista väsymysoireyhtymää sairastavan toimijuuden kokemuksia. Erityisenä tarkastelun kohteena ovat terveydenhuollon palvelu- ja hoitojärjestelmän vaikutukset sairastuneiden toimijuuteen. Aineisto on kerätty ennen konsensussuositusten julkaisemista. Tutkimus on laadullinen. Aineisto analysoitiin teoriaohjautuneen sisällönanalyysin avulla. Analysoinnissa hyödynnettiin Jyrkämän teoreettismetodologista viitekehystä toimijuuden modaliteeteista. Tuloksissa eri modaliteetit kietoutuivat monisyisesti toisiinsa osoittaen sairastumisen monimuotoisia ja kokonaisvaltaisia vaikutuksia ihmisen toimijuuteen. Sairastuminen horjuttaa kokemusta omasta kykeneväisyydestä, kuntoutumisen mahdollisuuksista ja osallisuudesta yhteiskuntaan. Omaan sairauteen liittyvä toimijuus lähti muodostumaan tilanteessa, jossa terveydenhuollosta puuttuivat toimivat hoitokäytännöt sekä sairauteen liittyvä ymmärrys ja osaaminen. Toimintakykyä kuntoutettiin ja sairauden herättämiä tuntemuksia purettiin läheisten ja vertaisten avulla. Terveydenhuollosta sairastuneet toivoivat saavansa tietoa sairaudesta, toimivia kuntoutuskäytäntöjä sekä ymmärrystä ja tukea sairauden herättämiin tuntemuksiin. Tulosten perusteella sairastuneiden toimijuutta voidaan vahvistaa ja tukea terveydenhuollossa monin eri tavoin. Sairauteen liittyviin ennakkoluuloihin ja asenteisiin vaikuttaminen, merkityksellisten rakenteellisten tekijöiden ja terveydenhuollon osaamisen vahvistaminen mahdollistaisivat kuntoutumista ja omaa sairauteen liittyvää toimijuuden rakentumista. Sairastunut on tärkeä kohdata myös inhimillisenä toimijana, jolle sairastumisella on kokemuksellisia, kulttuurisia ja sosiaalisia vaikutuksia.
Vuorovaikutus terveydenhuollon ammattihenkilöiden kanssa paljon terveyspalveluja tarvitsevien asiakkaiden arvioimana
Authors: Huhtakangas Moona , Tolvanen Mimmi , Kyngäs Helvi , Kanste Outi 
Published: October 2022

Runsas palvelutarve aiheuttaa haasteita sekä asiakkaille itselleen että terveyspalvelujärjestelmälle asiakkaiden pyrkiessä saamaan tarpeitaan vastaavaa hoitoa. Vuorovaikutus on tärkeää asiakkaan ja terveydenhuollon ammattihenkilöiden kohtaamisissa. Tutkimuksen tarkoituksena oli vertailla lyhyt- ja pitkäaikaisesti paljon terveyspalveluja tarvitsevien asiakkaiden näkemyksiä vuorovaikutuksesta terveydenhuollon ammattihenkilöiden kanssa. Lisäksi tarkoituksena oli testata samalla kohderyhmällä Patient-Professional Interaction Questionnaire PPIQ-mittarin faktorirakenteen yhdenmukaisuutta.
Aineisto kerättiin erään kaupungin hyvinvointipalveluiden pitkäaikaisesti (n=234) ja lyhytaikaisesti (n=261) paljon terveyspalveluja tarvitsevilta asiakkailta tammi-heinäkuussa 2020. Mittari sisälsi 16 vuorovaikutusta arvioivaa väittämää, jotka muodostavat neljä ulottuvuutta: tehokas kommunikaatio; kiinnostus asiakkaan näkemyksiä kohtaan; empatia; asiakkaan osallistaminen hoitoon. Kukin ulottuvuus sisälsi neljä väittämää. Aineisto analysoitiin Pearsonin khiin neliö -testillä, keski- ja hajontaluvuilla sekä Mann-Whitney U -testillä. Mittarin sisäistä johdonmukaisuutta arvioitiin Cronbachin alpha -reliabiliteettikertoimella ja mittausinvarianssia useamman ryhmän konfirmatorisella faktorianalyysillä.
Pitkäaikaisesti paljon terveyspalveluja tarvitsevat asiakkaat arvioivat vuorovaikutuksen ammattihenkilöiden kanssa keskimäärin heikommaksi kuin lyhytaikaisesti paljon terveyspalveluja tarvitsevat asiakkaat. Asiakkaan hoitoon osallistaminen oli keskeinen vuorovaikutukseen liittyvä tekijä pitkäaikaisesti paljon terveyspalveluja tarvitsevien asiakkaiden arvioimana. Useamman ryhmän konfirmatorisen faktorianalyysin perusteella PPIQ-mittarin rakenne ja lataukset olivat samanlaiset lyhyt- ja pitkäaikaisesti paljon terveyspalveluja tarvitsevien asiakkaiden ryhmissä, mutta vastaukset eri väittämiin vaihtelivat ryhmien välillä.
Paljon terveyspalveluja tarvitsevan asiakkaan ja terveydenhuollon ammattihenkilöiden välinen toimiva vuorovaikutus on tärkeä osa asiakaslähtöisiä terveyspalveluja.
The Dangerous Discourse of “Us” vs. “Them:” Spain's VOX Discursive Practices
Authors: Navarro Francisco de Borja , Yeh Aiden 
Published: October 2022

Abstract
Since the entry of the far-right party VOX into the Spanish government administrations in 2018, Spain's political scene has gone through a deep transformation. The disparity in opinions among the different parties concerning migration seems to tear the country's democratic foundation apart. This paper is a study of the language and discursive strategies used by VOX's leader, Santiago Abascal, articulating the party's populist propaganda for a united country to “make Spain great again.” The analysis was grounded on the theoretical underpinnings of Wodak's (2001) discursive strategies and Van Dijk's (1993) “Us” vs. “Them” framework. The data were based on Abascal's closing political campaign speech during the Madridlenian elections, which was televised in May 2021. The 30-minute video recording was transcribed, annotated, coded, and analyzed. The findings suggest a pattern of discursive practices aimed at diminishing other political parties and their representatives, vilify immigrants, and impugn government measures that were against VOX's authoritarian conservatism and nationalism. There was a predominant use of predication strategies to positively present VOX while denigrating its political rivals. Referential/nomination strategies were also used to divide the society between in-groups and out-groups. Strongly embedded in these strategies were perlocutionary acts used to incite hate toward the out-groups and evoke fear and anxiety toward the in-group, strategically employed as tools to gain votes in the elections.
Roles of Community Pharmacists in Cancer Management
Authors: Egbewande Oluwaseyi Muyiwa , Abdulwasiu Muhsinah Adesewa , Yusuf Rashidat Onyinoyi , Durojaye Aishat Bisoye , Ashimiyu-Abdusalam Zainab Ikeoluwa 
Published: October 2022

Community pharmacists are among the most easily accessible healthcare practitioners and are usually the first point of contact with the public or community. This is often due to their accessibility, credibility, and widespread within the public sector making them essential members of the healthcare team with significant contributions to the delivery of public health care. Community pharmacists, in addition to their known educational and awareness-raising roles, may play an essential role in risk assessment and screening of patients, detection of symptoms of probable malignancy, and cancer treatments. The pharmacy profession has been evolving from dispensing roles into more patient-oriented outcomes and pharmacists are now participating in more clinical interventions. This places community pharmacists in the best position to provide the necessary knowledge and healthcare to benefit populations at risk of cancer. Active involvement of community pharmacists in the care and management of cancer will significantly contribute to screening and risk assessment, early detection, treatment and eradication of breast, cervical, lung, ovarian and other forms of cancer. As a result, the community pharmacy setting must the developed to maximize its full potential in cancer care.
Deus ex Poiesis: A Manifesto for the End of the World and the Future of Art and Technology
Authors: Shanken Edward A. 
Published: October 2022

In 2020, the Doomsday Clock advanced to just one hundred seconds before nuclear midnight, the hour at which atomic armageddon would end the world as we know it. Using the Greek theatrical device of deus ex machina and Heidegger's reliance on poiesis as a liberating force from technological enframing, I propose the concept of deus ex poiesis as a potential model for addressing the seemingly insurmountable challenges of the anthropocene, an era in which industrial technologies have instigated global climatic changes on the scale of Earth's five mass extinctions. Drawing on additional theoretical insights from Gregory Bateson, Jack Burnham, Donna Haraway, Alva Noë, Rita Raley and others, my essay discusses two aesthetic approaches: 1) digital artworks that explicitly engage in forms of (h)activism through tactical media; 2 artworks that develop and apply ways of knowing that lie outside of rational scientific models and that explore hybrid forms of perception and expanded states of consciousness. Artists considered include Electronic Disturbance Theater, rTMark, Julian Oliver and Danja Vasiliev, Roy Ascott, Pauline Oliveros, and Kim Jeong-Han.
Making Nutritious Diets More Affordable: Findings from a Cost of Diet Assessment in West Singhbhum, Jharkhand, India
Authors: Dash Antaryami , Chanda Pranab Kumar , Das Sharmistha , Ali Atefh , Bhaumik Debashmita , Rana Md Masud , Santwani Neha 
Published: October 2022

Background: India bears a disproportionate burden of undernutrition. Access to an affordable, nutritious diet is one of the critical challenges. There is a need to assess the cost of a nutritious diet and find ways to understand and minimise the affordability gap through a comprehensive approach.
Objective: The present study was conducted in the West Singhbhum district of Jharkhand, India. Its objective was to find out the cost of various diets, and their affordability, based on households’ accounting for their total food expenditure, and assessing the coverage of essential governments’ nutrition-specific interventions to use a model for suggesting ways to minimise the affordability gap. We also estimate the potential impact of nutrition-sensitive programmes on household food affordability.
Methodology: The study employed the Cost of the Diet (CotD) methodology, a mixed-method, cross-sectional assessment, where the research team conducted surveys in 16 markets, 12 focus group discussions (FGDs) and 96 individual interviews (IDIs). Additionally, 434 household-level surveys were conducted to understand income, expenditure patterns in the localities and uptake of key nutrition-sensitive interventions. Secondary information from the 68th round of the National Sample Survey 2012 were used to assess rural Jharkhand’s non-food expenditure (NFE). Data were analysed primarily using the Save the Children’s Cost of the Diet software version 2.5.2.
Results: The cost of the diet increased with an increase in the diet quality – from a basic energy-only diet costing INR 33,892 ($505.85)[1] per year for a standard household with 6 members to a food-habit nutritious diet (FHAB) costing INR 70,627 ($1054.13) per year. More than half of the sampled households could not afford a nutritious diet. The poorest quartile was spending 56.8% of income on food, compared to 33.7% for the richest quintile.
Conclusion: The cost of a FHAB diet should be used as a benchmark to track the progress of beneficiary groups in upcoming socio-economic assessments. Changes in the affordability gap should be observed to assess whether new initiatives have worked. Optimal coverage of existing nutrition-specific and nutrition-sensitive programmes has the potential to reduce the cost of a FHAB nutritious diet by up to 30%.
[1] $1=INR 67 (The exchange rate at the time of data collection, December 2019)
Exploring Force Production Reliability across Different Levels of Clinical Experience during a Simulated One-handed Instrument-Assisted Soft Tissue Mobilization Treatment: A Pilot Study
Authors: Syeda Moni , Bartholomew Jason , Santiago Shayane Valenzuela , Reeves Ashley J , Martonick Nickolai JP , Cheatham Scott W , Baker Russell T 
Published: October 2022

Background Instrument-assisted soft tissue mobilization (IASTM) is a commonly utilized intervention for musculoskeletal pain and dysfunction. However, little is known regarding the reliability of forces applied by clinicians of different experience levels during an IASTM intervention. Purpose The purpose of this pilot study was to assess intra-clinician reliability of IASTM force (i.e., mean normal force) during a simulated, one-handed stroke IASTM intervention across different levels of IASTM clinical experience. Design Descriptive laboratory study. Methods The researchers conducted a repeated measures trial in a laboratory setting with a convenience sample of ten participants who had previously completed professional IASTM training. Participants performed 15 one-handed sweeping strokes with an IASTM instrument on a skin simulant attached to a force plate for a standardized hypothetical treatment scenario. The participants performed the treatment on two separate days, 24-48 hours apart. The researchers examined the intra-rater reliability for average (mean) normal forces using Bland-Altman (BA) plots and Coefficient of Variation (CV) values. Results The BA plot results indicated all participants (professional athletic training students = 4, athletic trainers = 6; males = 5, females = 5; age = 32.60 ± 8.71 y; IASTM experience = 3.78 ± 4.10 y), except participant D (1.9N, 190g), were consistently reliable within 1N (100g) or less of force for mean differences and within the maximum limits of agreement around 3.7N (370g). Most participants’ CV scores ranged between 8 to 20% supporting reliable force application within each treatment session. Conclusion The data indicated that IASTM trained clinicians could produce consistent forces within and across treatment sessions irrespective of clinical experience. Level of Evidence 3
Modelo exploratório de resolução de problemas na formação inicial de professores de Matemática
Authors: Marcatto Flávia Sueli Fabiani 
Published: October 2022

Este artigo trata da implementação de estudos em Educação Matemática, mais especificamente, do Modelo Exploratório de Resolução de Problemas (MERP), na formação inicial de professores de matemática, na abrangência das horas de prática como componente curricular. A metodologia de pesquisa baseada em design apoiou este processo de implementação. As tarefas de resolução de problemas, baseadas na perspectiva do MERP, constituíram uma proposta relevante na formação inicial de professores, pois os estudantes tiveram a oportunidade de conjecturar, explicar e produzir argumentos matemáticos e justificá-los; construir ideias, partindo das ideias uns dos outros, contribuindo para o desenvolvimento de sua capacidade e da vontade de se engajar com a matemática, resultando em uma identidade positiva como produtor de matemática e dando sentido aos processos de ensino por meio dos discursos dos colegas universitários.
QSAR Study on Diacylgycerol Acyltransferase-1 (DGAT-1) Inhibitor as Anti-diabetic using PSO-SVM Methods
Authors: Pramana I Kadek Andrean Pramana Putra , Reza Rendian Septiawan  , Isman Kurniawan  
Published: October 2022

Diabetes mellitus is a chronic disease that can occurred to anyone. Up until now, there are no specific drugs that have been found which can completely cure diabetes. One of the possible steps to treat diabetes mellitus is by inhibiting the growth of Diacylglycerol Acyltransferase-1 (DGAT-1) enzyme. This study aims to build a QSAR model on DGAT-1 inhibitors as anti-diabetic using Particle Swarm Optimization (PSO) and Support Vector Machine (SVM). Acyl-CoA: DGAT1 is a mikrosomal enzyme in lipogenesis which is increased in metabolically active cells to meet nutrient requirements. Microsomal-enzymes-that have an-important in the triglyceride-synthesis process-of 1,2-diacylglycerol by-catalyzing-acyl-coa-dependent-acylations as anti-diabetics. The dataset used in this study consists of 228 samples containing molecular structures and their inhibitor activities. We reduce the number of features by removing features with a standard deviation less than the threshold value, followed by the PSO algorithm. The best-predicted result is obtained through the implementation of SVM with RBF kernel, with the score of and are 0.75 and 0.67, respectively.
Perancangan Dan Pembuatan Sistem Informasi Pengarsipan Surat Pada SDN 26 Mataram
Authors: Putu Ayu Desi Anggara Santi  , Agitha Nadiyasari 
Published: October 2022

Hingga saat ini pengelolaan surat masih sering dilakukan secara manual atau konvensional, yang mana sering menyebabkan terjadinya kesalahan dalam penyimpanan dan pencarian data surat. Kesulitan tersebut dapat diatasi dengan membuat suatu sistem informasi, yaitu dengan menggunakan bahasa pemrograman PHP dan data base MySQL untuk mengelola arsip surat. Sistem informasi ini bertujuan untuk mengubah cara pengelolaan dan pengarsipan surat yang semula secara hard copy menjadi soft copy, sehingga dapat mempermudah pengguna dalam melakukan arsip surat. Metode yang digunakan adalah waterfall dengan beberapa tahapan yang runtut dari analisis kebutuhan, desain sistem, coding dan testing, penerapan program, serta pemeliharaan. Pengujian menggunakan user acceptance testing yang di dalamnya terdapat pengujian black box dan kuesioner. Berdasarkan pengujian yang telah dilakukan, maka didapatkan hasil bahwa responden yang merupakan pegawai di SDN 26 Mataram setuju dengan sistem informasi pengarsipan surat yang telah dibuat.
Analisis Rantai Nilai Dan Efisiensi Pemasaran Beras di Kabupaten Lombok Barat
Authors: Wuryantoro Wuryantoro , Candra Ayu 
Published: October 2022

The measurement of added value in the rice distribution flow is a strategic approach that can be used to increase competitive advantage, where customer value can be increased by better understanding the relationship between producers, suppliers (suppliers) and customers. One of the regencies in NTB with abundant rice/rice production is West Lombok Regency. Rice milling is one of the central points in the rice agroindustry and an institution that connects every actor in the post-harvest rice supply chain, starting from unhulled rice to producing rice as the main product. The purpose of this research is to identify and examine the rice value chain mechanism related to product flow, financial flow and information flow on rice commodity, as well as to analyze the efficiency of rice distribution channel. The results show that in the rice supply chain there has been a product flow, financial flow and information flow that flows between marketing actors or institutions, and is able to provide adequate profits for each actor involved in the rice supply chain. The results also show that in West Lombok Regency there are 3 patterns of marketing channels and overall the three rice marketing channels are efficient. This is indicated by the results of the calculation of the value of the marketing efficiency measurement, both the results of the analysis of the margin, efficiency index and price share, have met the efficient criteria.
Aktivitas antioksidan ekstrak air daun kelor (Moringa oleifera) dengan metode DPPH serta analisis kualitatif kandungan metabolit sekunder
Authors: Muna Laili 
Published: October 2022

Sunlight contains UV radiation which will have an impact on the skin if exposed continuously and cause premature aging of the skin. The use of cosmetic products that contain antioxidant compounds is needed to avoid premature aging due to exposure to UV rays. Antioxidants used in cosmetics generally come from synthetic compounds, namely BHT (Butyl hydroxytoluene) whose use will have a negative impact on the skin if used in the long term, so in this study, Moringa oleifera leaf was used as a natural antioxidant. The purpose of this study is to determine the antioxidant activity of Moringa leaf water extract by calculating IC50 and using a comparison standard of vitamin C. The method used in this study is the stratified maceration method with measurement of antioxidant activity using the DPPH method. The results showed that the aqueous extract of Moringa leaves contains secondary metabolites of flavonoids, tannins, saponins, and alkaloids that play a role in antioxidant activity. The test results of Moringa leaf water extract showed moderate antioxidant activity with an IC50 value of 87.54 ppm, while the comparison control vitamin C obtained an IC50 of 483.53 ppm. This is because vitamin C has been oxidized so that the ability to donate protons to DPPH free radicals is also reduced.