bluuebunny/crossref_metadata_2025_split huggingface dataset:
Autologous Platelet-Rich Plasma in Clitoral Reconstructive Surgery After Female Genital Mutilation/Cutting: A Pilot Case Study
Authors: Tognazzo Enrico , Berndt Sarah , Abdulcadir Jasmine 
Published: October 2022

AbstractBackgroundPostoperative healing after clitoral reconstruction (CR) for female genital mutilation/cutting can be long and painful due to prolonged clitoral re-epithelialization time (up to 3 months). Autologous platelet-rich plasma (A-PRP) might reduce postoperative clitoral epithelialization time and pain.ObjectivesThe authors assessed postoperative clitoral re-epithelialization time and pain after intraoperative clitoral administration of A-PRP.MethodsFive consecutive women underwent CR (Foldès technique) followed by the administration of A-PRP Regen Lab SA (Le Mont-sur-Lausanne, Switzerland) plasma and glue, injected inside and applied above the re-exposed clitoris, respectively. We recorded surgical complications, postoperative clitoral pain (visual analogue scale), painkiller intake, time to complete re-epithelialization, and the experienced subjective changes in sexual response and perception of their own body image referred by women.ResultsSexual distress/dysfunction as well as the desire to be physically and symbolically “repaired” were the reasons behind women's requests for surgery. None of the women suffered from chronic vulvar or non-vulvar pain. All women achieved complete clitoral epithelialization by day 80, 3 women between day 54 and 70, and only 1 woman was still taking 1 g of paracetamol twice a day at 2 months postoperative. She had stopped it before the 3-month control. There were no short- or long-term complications. All women described easier access and stimulation of their clitoris as well as improved sexual arousal, lubrication, and pleasure and claimed to be satisfied with their restored body image.ConclusionsA-PRP could expedite postoperative clitoral epithelialization and reduce postoperative pain after CR after female genital mutilation/cutting.Level of Evidence: 4
CEDA: integrating gene expression data with CRISPR-pooled screen data identifies essential genes with higher expression
Authors: Zhao Yue , Yu Lianbo , Wu Xue , Li Haoran , Coombes Kevin R , Au Kin Fai , Cheng Lijun , Li Lang 
Published: October 2022

AbstractMotivationClustered regularly interspaced short palindromic repeats (CRISPR)-based genetic perturbation screen is a powerful tool to probe gene function. However, experimental noises, especially for the lowly expressed genes, need to be accounted for to maintain proper control of false positive rate.MethodsWe develop a statistical method, named CRISPR screen with Expression Data Analysis (CEDA), to integrate gene expression profiles and CRISPR screen data for identifying essential genes. CEDA stratifies genes based on expression level and adopts a three-component mixture model for the log-fold change of single-guide RNAs (sgRNAs). Empirical Bayesian prior and expectation–maximization algorithm are used for parameter estimation and false discovery rate inference.ResultsTaking advantage of gene expression data, CEDA identifies essential genes with higher expression. Compared to existing methods, CEDA shows comparable reliability but higher sensitivity in detecting essential genes with moderate sgRNA fold change. Therefore, using the same CRISPR data, CEDA generates an additional hit gene list.Supplementary informationSupplementary data are available at Bioinformatics online.
Complementary contribution of the medial and lateral human parietal cortex to grasping: a repetitive TMS study
Authors: Breveglieri Rossella , Borgomaneri Sara , Filippini Matteo , Tessari Alessia , Galletti Claudio , Davare Marco , Fattori Patrizia 
Published: October 2022

AbstractThe dexterous control of our grasping actions relies on the cooperative activation of many brain areas. In the parietal lobe, 2 grasp-related areas collaborate to orchestrate an accurate grasping action: dorsolateral area AIP and dorsomedial area V6A. Single-cell recordings in monkeys and fMRI studies in humans have suggested that both these areas specify grip aperture and wrist orientation, but encode these grasping parameters differently, depending on the context. To elucidate the causal role of phAIP and hV6A, we stimulated these areas, while participants were performing grasping actions (unperturbed grasping). rTMS over phAIP impaired the wrist orientation process, whereas stimulation over hV6A impaired grip aperture encoding. In a small percentage of trials, an unexpected reprogramming of grip aperture or wrist orientation was required (perturbed grasping). In these cases, rTMS over hV6A or over phAIP impaired reprogramming of both grip aperture and wrist orientation. These results represent the first direct demonstration of a different encoding of grasping parameters by 2 grasp-related parietal areas.
Clinical Features of Patients Hospitalized for All Routes of Anthrax, 1880–2018: A Systematic Review
Authors: Hendricks Katherine , Person Marissa K , Bradley John S , Mongkolrattanothai Thitipong , Hupert Nathaniel , Eichacker Peter , Friedlander Arthur M , Bower William A 
Published: October 2022

Abstract

Background
Anthrax is a toxin-mediated zoonotic disease caused by Bacillus anthracis, with a worldwide distribution recognized for millennia. Bacillus anthracis is considered a potential biowarfare agent.

Methods
We completed a systematic review for clinical and demographic characteristics of adults and children hospitalized with anthrax (cutaneous, inhalation, ingestion, injection [from contaminated heroin], primary meningitis) abstracted from published case reports, case series, and line lists in English from 1880 through 2018, assessing treatment impact by type and severity of disease. We analyzed geographic distribution, route of infection, exposure to anthrax, and incubation period.

Results
Data on 764 adults and 167 children were reviewed. Most cases reported for 1880 through 1915 were from Europe; those for 1916 through 1950 were from North America; and from 1951 on, cases were from Asia. Cutaneous was the most common form of anthrax for all populations. Since 1960, adult anthrax mortality has ranged from 31% for cutaneous to 90% for primary meningitis. Median incubation periods ranged from 1 day (interquartile range [IQR], 0–4) for injection to 7 days (IQR, 4–9) for inhalation anthrax. Most patients with inhalation anthrax developed pleural effusions and more than half with ingestion anthrax developed ascites. Treatment and critical care advances have improved survival for those with systemic symptoms, from approximately 30% in those untreated to approximately 70% in those receiving antimicrobials or antiserum/antitoxin.

Conclusions
This review provides an improved evidence base for both clinical care of individual anthrax patients and public health planning for wide-area aerosol releases of B. anthracis spores.
Evaluation of Amoxicillin and Amoxicillin-Clavulanate (Augmentin) for Antimicrobial Postexposure Prophylaxis Following Bacillus anthracis Inhalational Exposure in Cynomolgus Macaques
Authors: Slay Raymond M , Hatch Graham J , Hewitt Judith A 
Published: October 2022

Abstract
Amoxicillin is a broad-spectrum antibiotic used to treat a variety of gram-positive and gram-negative infections, such as infections of the ear, nose, and throat, genitourinary tract, skin, and lower respiratory tract; gonorrhea; and Helicobacter pylori. The prophylactic benefit of both amoxicillin and Augmentin (amoxicillin-clavulanate for use against β-lactamase–expressing bacteria) was evaluated for inhalation anthrax in cynomolgus macaques in 2 studies. A pilot study on amoxicillin-clavulanate that used a portion of the study animals demonstrated empirically that dosing twice a day was efficacious. In a subsequent study on both amoxicillin and amoxicillin-clavulanate that used the remaining study animals, the animals were treated orally every 12 hours on days 1–28 postchallenge and followed for an additional 60 days (total of 88 days from day of aerosol challenge to when the animals were culled). The animals from each treatment arm of the 2 studies were completely protected. All untreated animals succumbed to the infection. The degree of protection observed in this study suggests that both amoxicillin and amoxicillin-clavulanate, administered prophylactically over a period of 28 days after a lethal exposure to Bacillus anthracis spores, is sufficient for full protection.
Postexposure Prophylaxis and Treatment of Bacillus anthracis Infections: A Systematic Review and Meta-analyses of Animal Models, 1947–2019
Authors: Kennedy Jordan L , Bulitta Jürgen B , Chatham-Stephens Kevin , Person Marissa K , Cook Rachel , Mongkolrattanothai Thitipong , Shin Eunjeong , Yu Patricia , Negron Maria E , Bower William A , Hendricks Katherine 
Published: October 2022

Abstract

Background
Anthrax is endemic to many countries, including the United States. The causative agent, Bacillus anthracis, poses a global bioterrorism threat. Without effective antimicrobial postexposure prophylaxis (PEPAbx) and treatment, the mortality of systemic anthrax is high. To inform clinical guidelines for PEPAbx and treatment of B. anthracis infections in humans, we systematically evaluated animal anthrax treatment model studies.

Methods
We searched for survival outcome data in 9 scientific search engines for articles describing antimicrobial PEPAbx or treatment of anthrax in animals in any language through February 2019. We performed meta-analyses of efficacy of antimicrobial PEPAbx and treatment for each drug or drug combination using random-effects models. Pharmacokinetic/pharmacodynamic relationships were developed for 5 antimicrobials with available pharmacokinetic data. Monte Carlo simulations were used to predict unbound drug exposures in humans.

Results
We synthesized data from 34 peer-reviewed studies with 3262 animals. For PEPAbx and treatment of infection by susceptible B. anthracis, effective monotherapy can be accomplished with fluoroquinolones, tetracyclines, β-lactams (including penicillin, amoxicillin-clavulanate, and imipenem-cilastatin), and lipopeptides or glycopeptides. For naturally occurring strains, unbound drug exposures in humans were predicted to adequately cover the minimal inhibitory concentrations (MICs; those required to inhibit the growth of 50% or 90% of organisms [MIC50 or MIC90]) for ciprofloxacin, levofloxacin, and doxycycline for both the PEPAbx and treatment targets. Dalbavancin covered its MIC50 for PEPAbx.

Conclusions
These animal studies show many reviewed antimicrobials are good choices for PEPAbx or treatment of susceptible B. anthracis strains, and some are also promising options for combating resistant strains. Monte Carlo simulations suggest that oral ciprofloxacin, levofloxacin, and doxycycline are particularly robust choices for PEPAbx or treatment.
Aiming too high or scoring too low? Heterogeneous immigrant–native gaps in upper secondary enrollment and outcomes beyond the transition in France
Authors: Ferrara Alessandro 
Published: October 2022

Abstract
The children of immigrants usually make more ambitious enrolment choices than native students with comparable socioeconomic status and academic achievement. Less is known about how ethnic choice effects vary by socioeconomic status and previous achievement simultaneously, and whether they only hold true for some immigrant–native comparisons. Moreover, few studies investigate outcomes after the educational transition, so the consequences of ambitious choices remain unclear. I investigate immigrant–native gaps in the decision to enroll in academic upper secondary education and in outcomes after the transition for two cohorts of French students. I find that ethnic choice effects are positive only for students with an intermediate or working class background, and are largest for those with lower to middle achievement from the working class. Migrant disadvantages in outcomes after the transition were reduced between cohorts. In the latest cohort, immigrant-origin and native students enrolled in academic upper secondary were equally likely to complete the track and enroll in tertiary education. However, immigrant-origin students were still disadvantaged in terms of graduation track, grades, and timing. Using counterfactual reweighting strategies, I show that similar and substantial portions of these disadvantages were explained by the ambitious academic choices and lower prior performance of immigrant-origin students. However, while their ambitious choices also increase enrolment rates and hence overall attainment for immigrant-origin students, their lower prior performance reduces both. I suggest that policies should reduce immigrant disadvantages in early achievement to allow high-aspiring, yet often disadvantaged, immigrant-origin students to succeed in ambitious educational paths.
The seismic dispersion and attenuation characteristics of organic shales
Authors: Li Hui , Huang Qi , Zhao Luanxiao , Wang Yirong , Cai Zhenjia , Qin Xuan , Gao Jinghuai , Han Dehua 
Published: October 2022

SUMMARY
To improve our understanding of wave dispersion and adsorption signature of organic shales, we select a set of vertical shale samples cored from different formations and conduct the forced-oscillation measurements in seismic frequencies of 2–800 Hz at the oven-dried conditions. The results demonstrated that both Young's modulus and Poisson's ratio of immature Barnett and Eagle Ford shales and mature Mancos shale remain roughly constant and the extensional attenuations are also insignificant at the entire frequency band. However, the mature Jungar shale exhibits strong dispersions with the magnitude of 23.4 per cent for Young's modulus at the confining pressure of 3.4 MPa. The dispersion and magnitude of Jungar shale overall exhibit a decreasing trend with increasing pressure, but still maintain strong attenuation at the confining pressure of 20.8 MPa. It is found that the single parameter of TOC, thermal maturity and clay content are not the controlling factors of wave dispersion and adsorption signatures. Instead, the geochemical index ${\rm{TOC}} \times {S_1}/({S_1}{\rm{ + }}{S_2})$ is positively correlated with dispersion and attenuation magnitude, suggesting that organic richness and maturity level jointly control the wave adsorption characteristics. Geochemical analysis and phenomenological modelling imply that such kinds of energy dissipation in organic shales are possibly caused by the viscous friction at interfaces between inorganic grains and the surface of liquefied or bitumen-filled organic matter. Besides, a modified standard linear solid model containing multiple sets of a characteristic frequency is proposed and well captures the continuous dispersion signatures considering that the Jungar shale contains various maturity-induced viscous organic matter.
Use of Straighteners and Other Hair Products and Incident Uterine Cancer
Authors: Chang Che-Jung , O’Brien Katie M , Keil Alexander P , Gaston Symielle A , Jackson Chandra L , Sandler Dale P , White Alexandra J 
Published: October 2022

AbstractBackgroundHair products may contain hazardous chemicals with endocrine-disrupting and carcinogenic properties. Previous studies have found hair product use to be associated with a higher risk of hormone-sensitive cancers including breast and ovarian cancer; however, to our knowledge, no previous study has investigated the relationship with uterine cancer.MethodsWe examined associations between hair product use and incident uterine cancer among 33 947 Sister Study participants aged 35-74 years who had a uterus at enrollment (2003-2009). In baseline questionnaires, participants in this large, racially and ethnically diverse prospective cohort self-reported their use of hair products in the prior 12 months, including hair dyes; straighteners, relaxers, or pressing products; and permanents or body waves. We estimated adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) to quantify associations between hair product use and uterine cancer using Cox proportional hazard models. All statistical tests were 2-sided.ResultsOver an average of 10.9 years of follow-up, 378 uterine cancer cases were identified. Ever vs never use of straightening products in the previous 12 months was associated with higher incident uterine cancer rates (HR = 1.80, 95% CI = 1.12 to 2.88). The association was stronger when comparing frequent use (&gt;4 times in the past 12 months) vs never use (HR = 2.55, 95% CI = 1.46 to 4.45; Ptrend = .002). Use of other hair products, including dyes and permanents or body waves, was not associated with incident uterine cancer.ConclusionThese findings are the first epidemiologic evidence of association between use of straightening products and uterine cancer. More research is warranted to replicate our findings in other settings and to identify specific chemicals driving this observed association.
The Enhancing Oncology Model: Leveraging improvement science to increase health equity in value-based care
Authors: Patel Tej A , Jain Bhav , Parikh Ravi B 
Published: October 2022

Abstract
The Oncology Care Model (OCM), launched in 2016 by the Centers for Medicare and Medicaid Services, was the first demonstration of value-based payment in oncology. Although the OCM delivered mixed results in terms of quality of care and total episode costs, the model had no statistically significant impact on remediating racial, ethnic, and socioeconomic disparities among beneficiaries. These deficits have been prominent in other aspects of US healthcare, and as a result, the Institute for Healthcare Improvement has advocated for stakeholders to leverage improvement science, an applied science that focuses on implementing rapid cycles for change, to identify and overcome barriers to health equity. With the announcement of the new Enhancing Oncology Model, a continuation of the OCM’s efforts in introducing value to cancer care for episodes surrounding chemotherapy administration, both policymakers and providers must apply tenets of improvement science and make eliminating disparities in alternative payment models a forefront objective. In this commentary, we discuss previous inequities in alternative payment models, the role that improvement science plays in addressing health-care disparities, and steps that stakeholders can take to maximize equitable outcomes in the Enhancing Oncology Model.
On the evolution of pebble-accreting planets in evolving protoplanetary discs
Authors: Pierens Arnaud 
Published: October 2022

ABSTRACTWe examine the migration of luminous low-mass cores in laminar protoplanetary discs where accretion occurs mainly because of disc winds and where the planet luminosity is generated by pebble accretion. Using 2D hydrodynamical simulations, we determine the eccentricities induced by thermal forces as a function of gas and pebble accretion rates, and also evaluate the importance of the torque exerted by the solid component relative to the gas torque. For a gas accretion rate $\dot{M}= 2\times 10^{-8}\, \mathrm{ M}_\odot$ yr−1 and pebble flux $\dot{M}_{\mathrm{ peb}}=170\, \mathrm{ M}_\oplus$ Myr−1, we find that embryo eccentricities attain values comparable to the disc aspect ratio. The planet radial excursion in the disc, however, causes the torque exerted by inflowing pebbles to cancel on average and migration to transition from outward to inward. This is found to arise because the magnitude of thermal torques decreases exponentially with increasing eccentricity, and we provide a fitting formula for the thermal torque attenuation as a function of eccentricity. As the disc evolves, the accretion luminosity becomes at some point too small to make the core eccentricity grow such that the solid component can exert a non-zero torque on the planet. This torque is positive and for gas accretion rates $\dot{M} \lesssim 5\times 10^{-9}$M⊙ yr−1 and pebble fluxes $\dot{M}_{\rm {peb}} \lesssim 120\, \mathrm{ M}_\oplus $ Myr−1, it is found to overcome the gas torque exerted on cores with mass $m_\mathrm{ p}\lesssim \, 1\,\mathrm{ {M}}_\oplus$, resulting in outward migration.
The miniJPAS survey quasar selection – I. Mock catalogues for classification
Authors: Queiroz Carolina , Abramo L Raul , Rodrigues Natália V N , Pérez-Ràfols Ignasi , Martínez-Solaeche Ginés , Hernán-Caballero Antonio , Hernández-Monteagudo Carlos , Lumbreras-Calle Alejandro , Pieri Matthew M , Morrison Sean S , Bonoli Silvia , Chaves-Montero Jonás , Chies-Santos Ana L , Díaz-García L A , Fernandez-Soto Alberto , González Delgado Rosa M , Alcaniz Jailson , Benítez Narciso , Javier Cenarro A , Civera Tamara , Dupke Renato A , Ederoclite Alessandro , López-Sanjuan Carlos , Marín-Franch Antonio , Mendes de Oliveira Claudia , Moles Mariano , Muniesa David , Sodré Laerte , Taylor Keith , Varela Jesús , Vázquez Ramió Héctor 
Published: October 2022

ABSTRACT
In this series of papers, we employ several machine learning (ML) methods to classify the point-like sources from the miniJPAS catalogue, and identify quasar candidates. Since no representative sample of spectroscopically confirmed sources exists at present to train these ML algorithms, we rely on mock catalogues. In this first paper, we develop a pipeline to compute synthetic photometry of quasars, galaxies, and stars using spectra of objects targeted as quasars in the Sloan Digital Sky Survey. To match the same depths and signal-to-noise ratio distributions in all bands expected for miniJPAS point sources in the range 17.5 ≤ r &lt; 24, we augment our sample of available spectra by shifting the original r-band magnitude distributions towards the faint end, ensure that the relative incidence rates of the different objects are distributed according to their respective luminosity functions, and perform a thorough modelling of the noise distribution in each filter, by sampling the flux variance either from Gaussian realizations with given widths, or from combinations of Gaussian functions. Finally, we also add in the mocks the patterns of non-detections which are present in all real observations. Although the mock catalogues presented in this work are a first step towards simulated data sets that match the properties of the miniJPAS observations, these mocks can be adapted to serve the purposes of other photometric surveys.
Conservation of transcriptional regulation by BRCA1 and BARD1 inCaenorhabditis elegans
Authors: Thapa Ishor , Vahrenkamp Russell , Witus Samuel R , Lightle Caitlin , Falkenberg Owen , Sellin Jeffries Marlo K , Klevit Rachel E , Stewart Mikaela D 
Published: October 2022

AbstractThe tumor-suppressor proteins BRCA1 and BARD1 function as an E3 ubiquitin ligase to facilitate transcriptional repression and DNA damage repair. This is mediated in-part through its ability to mono-ubiquitylate histone H2A in nucleosomes. Studies in Caenorhabditis elegans have been used to elucidate numerous functions of BRCA1 and BARD1; however, it has not been established that the C. elegans orthologs, BRC-1 and BRD-1, retain all the functions of their human counterparts. Here we explore the conservation of enzymatic activity toward nucleosomes which leads to repression of estrogen-metabolizing cytochrome P450 (cyp) genes in humans. Biochemical assays establish that BRC-1 and BRD-1 contribute to ubiquitylation of histone H2A in the nucleosome. Mutational analysis shows that while BRC-1 likely binds the nucleosome using a conserved interface, BRD-1 and BARD1 have evolved different modes of binding, resulting in a difference in the placement of ubiquitin on H2A. Gene expression analysis reveals that in spite of this difference, BRC-1 and BRD-1 also contribute to cyp gene repression in C. elegans. Establishing conservation of these functions in C. elegans allows for use of this powerful model organism to address remaining questions regarding regulation of gene expression by BRCA1 and BARD1.