bluuebunny/crossref_metadata_2025_split huggingface dataset:
CT-based radiomics nomogram for the pre-operative prediction of lymphovascular invasion in colorectal cancer: a multicenter study
Authors: Li Manman , Gu Hongmei , Xue Ting , Peng Hui , Chen Qiaoling , Zhu Xinghua , Duan Shaofeng , Feng Feng 
Published: November 2022

Objective:
To develop and externally validate a CT-based radiomics nomogram for the pre-operative prediction of lymphovascular invasion (LVI) in patients with colorectal cancer (CRC).

Methods:
357 patients derived from 2 centers with pathologically confirmed CRC were included in this retrospective study. Two-dimensional (2D) and three-dimensional (3D) radiomics features were extracted from portal venous phase CT images. The least absolute shrinkage and selection operator algorithm and logistic regression were used for constructing 2D and 3D radiomics models. The radiomics nomogram was developed by integrating the radiomics score (rad-score) and the clinical risk factor.

Results:
The rad-score was significantly higher in the LVI+ group than in the LVI- group (p &lt; 0.05). The area under the curve (AUC), accuracy, sensitivity and specificity of the 3D radiomics model were higher than those of the 2D radiomics model. The AUCs of 3D and 2D radiomics models in the training set were 0.82 (95% CI: 0.75–0.89) and 0.74 (95% CI: 0.66–0.82); in the internal validation set were 0.75 (95% CI: 0.65–0.85) and 0.67 (95% CI: 0.56–0.78); in the external validation set were 0.75 (95% CI: 0.64–0.86) and 0.57 (95% CI: 0.45–0.69); respectively. The AUCs of the nomogram integrating the optimal 3D rad-score and clinical risk factors (CT-reported T stage, CT-reported lymph node status) in the internal set and external validation set were 0.82 (95% CI: 0.73–0.91) and 0.80 (95% CI: 0.68–0.91), respectively.

Conclusion:
Both 2D and 3D radiomics models can predict LVI status of CRC. The nomogram combining the optimal 3D rad-score and clinical risk factors further improved predictive performance.

Advances in knowledge:
This is the first study to compare the difference in performance of CT-based 2D and 3D radiomics models for the pre-operative prediction of LVI in CRC. The prediction of the nomogram could be improved by combining the 3D radiomics model with the imaging model, suggesting its potential for clinical application.
Tourette syndrome research highlights from 2021
Authors: Hartmann Andreas , Andrén Per , Atkinson-Clement Cyril , Czernecki Virginie , Delorme Cécile , Debes Nanette Marinette , Szejko Natalia , Ueda Keisuke , Black Kevin 
Published: November 2022

We summarize selected research reports from 2021 relevant to Tourette syndrome that the authors consider most important or interesting. The authors welcome article suggestions and thoughtful feedback from readers.
Cointegration and causality relationship of Indian stock market with selected world markets
Authors: Ali Farman , Suri Pradeep , Kaur Tarunpreet , Bisht Deepa 
Published: November 2022

Background: The purpose of this study is to explore the trends and causes of established and emerging nations' stock market integration with India. The National Stock Exchange (NSE) indices act as a counterweight to international market indices. This study investigates the sustained interest of foreign investors in the Indian stock market in the wake of capital market reforms, as well as whether it moves in tandem with other markets in Asia and the United States. Methods: Our study examined the possibility of cross-country cointegration between the largest economies and indices around the world using multiple financial econometric models, such as Augmented Dickey-Fuller, Unit Root, Correlation, and Johansen Cointegration. Results: The findings of this study significantly support the notion that Indian and international financial markets are highly integrated. Vector error correction model indicates that the Indian market (NSE) is highly cointegrated with the US market (National Association of Securities Dealers Automated Quotations) and increased volatility signifies global contagion. Conclusion: A cursory examination of the data reveals distinct investment and portfolio diversification options for global investors. This could assist regulators in formulating more effective rules regarding price discovery processes.
Assessment of medication-related burden among a sample of Iraqi patients with systemic lupus erythematosus and its relationship with disease activity: a cross-sectional study
Authors: Kadhim Abbas Hawraa , Jabbar Kadhim Dheyaa , Isho Gorial Faiq , Shareef Laith G. 
Published: November 2022

Background: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with high morbidity and disability. The routines involved in taking medications, side effects, the nature of medicines, difficulties with the healthcare system, and disruptions to social activities all contribute to patients frequently experiencing medication-related burdens (MRB). The current study aimed to assess the perceived MRB among a sample of SLE patients from Iraq and to look for any possible relationship between MRB and disease activity. Methods: The current study was cross-sectional on diagnosed SLE patients who arrived at Baghdad Teaching Hospital/Medical City/Rheumatology department from September 2021 to January 2022. MRB was measured using the Living with Medicines Questionnaire (LMQ). Results: The study recruited 156 SLE patients. The patients were 35.8 ±11.7 years old on average. Great majority of them were women (96.8 %). The average LMQ score was 117.30± 18.37. The results showed that most patients (69.87%) experienced a moderate level of burden, followed by a low level (19.87%), high level (7.69%), and no burden at all (2.56%). No patients experienced an extremely high level of burden (0.0%). The mean burden scores for two LMQ domains—relationships with health care professionals (HCPs) and effectiveness of prescription medications—were the lowest (below average). Conclusions: Many of the SLE patients in this study reported experiencing MRB. Healthcare professionals should implement strategies to reduce this burden, particularly for low-income patients.
Рredicting epizootic risks of leptospirosis
Authors: Kozishkurt E. , Talalaev K. , Melnik O. , Sovirda O. , Gerasimenko E. , Kostolonova L. 
Published: November 2022

Leptospirosis is an infectious disease of humans and animals that is caused by pathogenic spirochetes of the genus Leptospira. It is considered the most common zoonosis in the world and is associated with settings of poor sanitation and agricultural occupations involving contact with animals or water. The authors have analyzed the present day world and particular Ukrainian situation with leptospirorsis and pointed out the urgent measures which could prevent its prevalence.
Overcoming the Impact of Online Games through Literacy for Junior High School Students in South Tangerang City
Authors: Romadlan Said , Muhammad Maududi Mukhlis 
Published: November 2022

Background: A form of communication technology widely played today is an online game, which is a type of game that utilizes computer networks. However, this type of game can cause addictive effects in the long run, such as in the case of Islamic Junior High School students Raudlatul Hikmah, thereby leading to decreased learning performance. This research aims to provide online game literacy training, such as the development, characteristics, and forms of online gaming, regulation, ethics, and the effects of online games, and tips on overcoming them.
Contribution: This research contributes to students' understanding of the development characteristics and forms of online games, as well as the regulations, ethics, and their effects, to overcome its negative impacts.
Method: Methods applied include sharing experiences in using online games, presentations and discussions on its literacy, and questionnaire and guided group discussions on online game problems.
Results: The results showed that on the average, 82% of students understand the development, characteristics, and types of online games. Meanwhile, 96% understand its effects, while 85% have adequate knowledge of the tips needed to overcome the associated adverse effects.
Conclusion: In conclusion, the objectives set by this training program can meet the target of providing online game literacy for Islamic Junior High School students Raudlatul Hikmah
Learning in the Digital Age During the COVID-19 Pandemic for School Improvement
Authors: Lee Bih Ni 
Published: November 2022

Background: Digital learning became increasingly popular when the COVID-19 disaster hit. Even though, its implementation is still less popular after no special indicators are used to create systematic learning. Comprehensive access to online education with fifth generation (5G) mobile technology coverage will enhance the quality of learning in the face of the digital age.
Contribution: The contribution of this study is to increase the awareness of online learning during the COVID-19 pandemic. It recognizes the importance of strengthening online learning when schools close. It also highlights digital technologies and practices for school improvement and enters an endemic era.
Method: Synthesis method. Researcher synthesized information naturally to help others see connections between things.
Results: The presence of the COVID-19 threat has opened a new norm in pedagogical methods in Malaysia. The use of technology has long been championed since 2013. Its importance became apparent after the emergence of the pandemic in early 2020. Not because of pandemic had to give way to technology but the times need change according to the currents of modernity and high technology. Since then, we have faced the threat of a pandemic and through a life of new norms. The convenience of computers and smartphones has changed the current learning process.
Conclusion: The COVID-19 pandemic has affected the structure of Learning and Teaching in Malaysian educational institutions. Education institutions were also instructed to close and the live or face-to-face method of Learning and Teaching was changed to fully online Learning and Teaching. The education system will undergo changes of learning in the digital age. Digital learning also continues to be the new norm of pedagogy in the future.
Reliability of the National Institutes of Health Stroke Scale
Authors: McLoughlin Alison , Olive Philippa , Lightbody Catherine Elizabeth 
Published: November 2022

Background: The National Institutes of Health Stroke Scale (NIHSS) is widely used to measure stroke deficits and is deemed to be reliable when used by a range of professionals. Aims: This study aimed to establish the inter-rater reliability of the NIHSS when completed via telemedicine. Secondary aims were to explore if professional group, length of time since training and/or re-certification, frequency of use and reason for using the NIHSS influenced the inter-rater reliability. Methods: A total of 30 video clips, the equivalent of two whole patient assessments for each of the 15 NIHSS items, were analysed by a range of NIHSS-certified clinical participants. Of these, 10 were nurses and five were consultants. Kappa statistics were used to calculate the inter-rater reliability for each item, with additional data on the range of agreement of items. Data across group characteristics were compared to test hypotheses about factors that could impact reliability. Findings: Overall, the inter-rater reliability was found to be lower than anticipated, and there was a wide variation in ratings. Consultants tended to score better than nurses, and, counter-intuitively, stroke specialist staff and those who used the NIHSS more frequently tended to have poorer reliability than their counterparts. Total agreement on score was only achieved in five out of the 30 video clips (16.6%), with agreement better at either end of the scoring range (i.e. no deficit or worst deficit). These findings indicate that reliability of the NIHSS may be lower than anticipated. Conclusion: Further research is needed to better understand the poor reliability of the NIHSS, as this has implications for care decisions and patient outcomes.
A nationwide study of blood transfusion in hip fracture patients
Authors: Farrow Luke , Brasnic Lorena , Martin Caroline , Ward Kirsty , Adam Karen , Hall Andrew J. , Clement Nick D. , MacLullich Alasdair M. J. 
Published: November 2022

Aims The aim of this study was to examine perioperative blood transfusion practice, and associations with clinical outcomes, in a national cohort of hip fracture patients. Methods A retrospective cohort study was undertaken using linked data from the Scottish Hip Fracture Audit and the Scottish National Blood Transfusion Service between May 2016 and December 2020. All patients aged ≥ 50 years admitted to a Scottish hospital with a hip fracture were included. Assessment of the factors independently associated with red blood cell transfusion (RBCT) during admission was performed, alongside determination of the association between RBCT and hip fracture outcomes. Results A total of 23,266 individual patient records from 18 hospitals were included. The overall rate of blood transfusion during admission was 28.7% (n = 6,685). There was inter-hospital variation in transfusion rate, ranging from 16.6% to 37.4%. Independent perioperative factors significantly associated with RBCT included older age (90 to 94 years, odds ratio (OR) 3.04 (95% confidence interval (CI) 2.28 to 4.04); p < 0.001), intramedullary fixation (OR 7.15 (95% CI 6.50 to 7.86); p < 0.001), and sliding hip screw constructs (OR 2.34 (95% CI 2.19 to 2.50); p < 0.001). Blood transfusion during admission was significantly associated with higher rates of 30-day mortality (OR 1.35 (95% CI 1.19 to 1.53); p < 0.001) and 60-day mortality (OR 1.54 (95% CI 1.43 to 1.67); p < 0.001), as well as delays to postoperative mobilization, higher likelihood of not returning to their home, and longer length of stay. Conclusion Blood transfusion after hip fracture was common, although practice varied nationally. RBCT is associated with adverse outcomes, which is most likely a reflection of perioperative anaemia, rather than any causal effect. Use of RBCT does not appear to reverse this effect, highlighting the importance of perioperative blood loss reduction. Cite this article: Bone Joint J 2022;104-B(11):1266–1272.
A combination of high preoperative pain and low radiological grade of arthritis is associated with a greater intensity of persistent pain 12 months after total knee arthroplasty
Authors: Klasan Antonio , Rice David A. , Kluger Michal T. , Borotkanics Robert , McNair Peter J. , Lewis Gwyn N. , Young Simon W. 
Published: November 2022

AimsDespite new technologies for total knee arthroplasty (TKA), approximately 20% of patients are dissatisfied. A major reason for dissatisfaction and revision surgery after TKA is persistent pain. The radiological grade of osteoarthritis (OA) preoperatively has been investigated as a predictor of the outcome after TKA, with conflicting results. The aim of this study was to determine if there is a difference in the intensity of pain 12 months after TKA in relation to the preoperative radiological grade of OA alone, and the combination of the intensity of preoperative pain and radiological grade of OA.MethodsThe preoperative data of 300 patients who underwent primary TKA were collected, including clinical information (age, sex, preoperative pain), psychological variables (depression, anxiety, pain catastrophizing, anticipated pain), and quantitative sensory testing (temporal summation, pressure pain thresholds, conditioned pain modulation). The preoperative radiological severity of OA was graded according to the Kellgren-Lawrence (KL) classification. Persistent pain in the knee was recorded 12 months postoperatively. Generalized linear models explored differences in postoperative pain according to the KL grade, and combined preoperative pain and KL grade. Relative risk models explored which preoperative variables were associated with the high preoperative pain/low KL grade group.ResultsPain 12 months after TKA was not associated with the preoperative KL grade alone. Significantly increased pain 12 months after TKA was found in patients with a combination of high preoperative pain and a low KL grade (p = 0.012). Patients in this group were significantly more likely to be male, younger, and have higher preoperative pain catastrophizing, higher depression, and lower anxiety (all p ≤ 0.05).ConclusionCombined high preoperative pain and low radiological grade of OA, but not the radiological grade alone, was associated with a higher intensity of pain 12 months after primary TKA. This group may have a more complex cause of pain that requires additional psychological interventions in order to optimize the outcome of TKA. Cite this article: Bone Joint J 2022;104-B(11):1202–1208.
Periprosthetic joint infection: what next?
Authors: Rajput Vishal , Meek R. M. D. , Haddad Fares S. 
Published: November 2022

Periprosthetic joint infection (PJI) remains an extremely challenging complication. We have focused on this issue more over the last decade than previously, but there are still many unanswered questions. We now have a workable definition that everyone should align to, but we need to continue to focus on identifying the organisms involved. Surgical strategies are evolving and care is becoming more patient-centred. There are some good studies under way. There are, however, still numerous problems to resolve, and the challenge of PJI remains a major one for the orthopaedic community. This annotation provides some up-to-date thoughts about where we are, and the way forward. There is still scope for plenty of research in this area. Cite this article: Bone Joint J 2022;104-B(11):1193–1195.
Finding point method and re-optimized method for the brightness temperature simulation from Fengyun 4A AGRI in infrared channels
Authors: Zhu Mingwei , Jin Shuanggen , Di Di 
Published: November 2022

The correlated

k

-distribution (CKD) is a fast
radiative transfer model and is often used in atmospheric absorption
simulation. In the paper, we apply two automatic CKD methods to
satellite brightness temperature simulations from the Fengyun 4A
Advanced Geostationary Radiation Imager (AGRI) in infrared channels,
namely, the finding point method (FPM) and the re-optimized method
(ROM). In the calculation, we used Radiative Transfer for the
Television Observation Satellite Operational Vertical Sounder (RTTOV)
as the comparison, and we use line-by-line (LBL) integration as the
reference. Compared with LBL in the brightness temperature simulation
of real profiles, the errors of FPM in 7.1 µm and
13.5 µm channels are 0.22 K,

−
0.13

K

for mean error and 0.3128 K,
0.2184 K for root mean square error (RMSE), respectively, which
are larger than that of RTTOV, with 0.16 K, 0.02 K,
0.2144 K, and 0.1226 K, respectively. In the other
channels, the results show that of ROM has the highest accuracy and
RTTOV has the lowest accuracy. In general, FPM and ROM can achieve
very good accuracy in satellite infrared remote sensing.
Influence of RVGA’s height on suppressing the aero-optical effects induced by a supersonic mixing layer
Authors: Xia Zihao , Ding Haolin , Xu Xiwang , Yi Shihe 
Published: November 2022

The supersonic mixing layer formed on the surface of hypersonic/supersonic flight vehicles’ optical windows is the main structure that induces aero-optical effects (AOEs), which may cause severe imaging degradation. Previous research has found that the ramp vortex generator array (RVGA) with a height of 1 mm can suppress the AOE of a

M
c
=

0.17

supersonic mixing layer. In this paper, three RVGAs with different heights are considered. The nano-tracer-based planar laser scattering technique and ray tracing method are applied to do the aero-optical analysis. The root mean square of the optical path difference (

O
P
D

r
m
s

), Strehl ratio (SR), imaging displacement (ID), and angle deviation (AD) are taken as evaluation parameters. It is found that a smaller aperture size (

A

D

) corresponds to a better SR in the aperture size range of

5

m
m

∼

100

m
m

. Then a beam with an incident angle

α
=

15

∘

and a 15 mm

A

D

is used to study the influence of RVGA’s height on suppressing the AOE. When the RVGA is applied, the

I
D

¯

and

A
D

¯

(overline means time-averaged results) in different sections of the supersonic mixing layer are significantly normalized, which can simplify the AOE’s correction procedure. The higher the RVGA is, the more the

O
P

D

r
m
s

¯

is reduced and the weaker the AOE is. RVGA1 (

h
=

1.2

m
m

) has the best performance in suppression of the AOE because it introduces much more disturbance than RVGA2 (

h
=

1.0

m
m

) and RVGA3 (

h
=

0.5

m
m

) and achieves better inhibition of the formation and development of the K-H vortices and more reduction of the whole thickness of the supersonic mixing layer.
Mesoscopic oblique plane microscopy with a diffractive light-sheet for large-scale 4D cellular resolution imaging
Authors: Shao Wenjun , Chang Minzi , Emmerich Kevin , Kanold Patrick O. , Mumm Jeff S. , Yi Ji 
Published: November 2022

Fundamental understanding of large-scale dynamic connectivity within a living organism requires volumetric imaging over a large field of view (FOV) at biologically relevant speed and resolution. However, most microscopy methods make trade-offs between FOV and axial resolution, making it challenging to observe highly dynamic processes at cellular resolution in 3D across mesoscopic scales (e.g., whole zebrafish larva). To overcome this limitation, we have developed mesoscopic oblique plane microscopy (Meso-OPM) with a diffractive light sheet. By augmenting the illumination angle of the light sheet with a transmission grating, we improved the axial resolution approximately sixfold over existing methods and approximately twofold beyond the diffraction limitation of the primary objective lens. We demonstrated a FOV up to

5.4

m
m

×

3.3

m
m

with resolution of

2.5

µ

m

×

3

µ

m

×

6

µ

m

, allowing volumetric imaging of 3D cellular structures with a single scan. Applying Meso-OPM for in vivo imaging of zebrafish larvae, we report here in toto whole-body volumetric recordings of neuronal activity at 2 Hz volume rate and whole-body volumetric recordings of blood flow dynamics at 5 Hz with 3D cellular resolution.
Immune checkpoint inhibitor monotherapy is associated with less cardiac toxicity than combination therapy
Authors: Cone Eugene B. , Haeuser Lorine , Reese Stephen W. , Marchese Maya , Nguyen David-Dan , Nabi Junaid , Chou Wesley H. , Noldus Joachim , McKay Rana R. , Kilbridge Kerry Laing , Trinh Quoc-Dien 
Published: November 2022

Background
Treatment options for many cancers include immune checkpoint inhibitor (ICI) monotherapy and combination therapy with impressive clinical benefit across cancers. We sought to define the comparative cardiac risks of ICI combination and monotherapy.

Methods
We used VigiBase, the World Health Organization pharmacovigilance database, to identify cardiac ADRs (cADRs), such as carditis, heart failure, arrhythmia, myocardial infarction, and valvular dysfunction, related to ICI therapy. To explore possible relationships, we used the reporting odds ratio (ROR) as a proxy of relative risk. A lower bound of a 95% confidence interval of ROR > 1 reflects a disproportionality signal that more ADRs are observed than expected due to chance.

Results
We found 2278 cADR for ICI monotherapy and 353 for ICI combination therapy. Combination therapy was associated with significantly higher odds of carditis (ROR 6.9, 95% CI: 5.6–8.3) versus ICI monotherapy (ROR 5.0, 95% CI: 4.6–5.4). Carditis in ICI combination therapy was fatal in 23.4% of reported ADRs, compared to 15.8% for ICI monotherapy (P = 0.058).

Conclusions
Using validated pharmacovigilance methodology, we found increased odds of carditis for all ICI therapies, with the highest odds for combination therapy. Given the substantial risk of severe ADR and death, clinicians should consider these findings when prescribing checkpoint inhibitors.