bluuebunny/crossref_metadata_2025_split huggingface dataset:
Palladium‐catalyzed synthesis of novel pyrido[3,4‐d]pyridazin‐1(2H)‐ones as promising α‐glucosidase, α‐amylase and EGFR inhibitors along with molecular docking
Authors: Radia Ashish J. , Lalpara Jaydeep N. , Hadiyal Sanjay D. , Kaneria Mital , Tirgar Pravin R. , Dubal Gaurang. G. 
Published: December 2022

AbstractA novel route has been established for the synthesis of novel pyrido[3,4‐d]pyridazin‐1(2H)‐one derivative. Synthesis of intermediate 4‐methyl‐7‐(piperazin‐1‐yl)pyrido[3,4‐d]pyridazin‐1(2H)‐one carried out in the presence of Pd(PPh3)2Cl2 catalyst. Ten novel derivatives were synthesized, isolated, and characterized by various spectroscopic techniques. All synthesized molecules were screened for in silico parameters and evaluated for α‐glucosidase and α‐amylase inhibitory assay. Furthermore, all synthesized molecules were screened for anticancer activity against human lung cell line (A549), human melanoma cell line (A375) and breast cancer (MCF‐7) cell lines and their cytotoxic effects were compared. Among the compounds, 8i showed higher inhibition than standard acarbose in the antidiabetic assay. In addition, 8 g exhibited more potency than positive control doxorubicin on lung, breast, and melanoma cancer cell lines. A molecular docking study was carried out on 1RPK and 4HJO as Epidermal growth factor receptor (EGFR) proteins.
The life‐cycle and restoration of the human vocal fold
Authors: Hamilton Nick J. I. 
Published: December 2022

AbstractObjectiveTo better understand the challenges of designing therapies to treat damaged vocal fold lamina propria, it is essential to understand the biophysical and pathophysiological mechanisms involved in vocal fold development, maintenance, injury, and aging. This review critically analyses these points to try and direct future efforts and new strategies toward science‐based solutions.Data Sources & Review MethodsMEDLINE, Ovid Embase, and Wed of Science databases were used to identify relevant literature. A scoping review was performed following the preferred reporting items for systematic reviews and meta‐analyses extension for scoping reviews checklist.ResultsThe layered arrangement of the vocal fold, develops during early childhood and is maintained during adulthood unless injury occurs. The stellate cells of the macular flava are likely to be important in this process. The capacity for vocal fold regeneration and growth is lost during adulthood and repair results in the deposition of fibrous tissue from resident fibroblasts. With advancing age, viscoelastic tissue declines, possibly due to cell senescence. Strategies aimed at replacing fibrous tissue within the vocal folds must either stimulate resident cells or implant new cells to secrete healthy extracellular protein. Injection of basic fibroblast growth factor is the most widely reported therapy that aims to achieve this.ConclusionsThe pathways involved in vocal fold development, maintenance and aging are incompletely understood. Improved understanding has the potential to identify new treatment targets that could potentially overcome loss of vocal fold vibratory tissue.
Phase Behavior of Double Zwitterionic Block Copolymers in Water: Morphology Transition through Concentration Dependent Selectivity of Water Partitioning
Authors: Higaki Yuji , Takahashi Masaya , Masuda Takumi 
Published: December 2022

AbstractPhase behavior of double zwitterionic diblock copolymers composed of a poly(carboxybetaine methacrylate) (PCB2) and a poly(sulfobetaine methacrylate) (PSB4) (PCB2n‐b‐PSB4m) has been mapped out in aqueous solutions. Phase diagrams are constructed with polymer concentration, ϕ, ranging from 0.08 to 0.80 and PSB4 volume fraction in the PCB2n‐b‐PSB4ms, fPSB4, ranging from 0.23 to 0.93 at 25 °C. PCB2n‐b‐PSB4m aqueous solutions show symmetric phase diagram above ϕ = 0.55, indicating that water is nearly neutral with respect to PCB2 and PSB4. The morphology transforms from columnar with PCB2 cylinders to lamellar to columnar with PSB4 cylinders with decreasing ϕ, and the phase boundaries exhibit a negative slope below ϕ = 0.45. The morphology transition is rationalized in terms of interfacial curvature modulation through the volume expansion of the PCB2 phase due to the selective water partitioning. The lyotropic mesophase of double hydrophilic block copolymers is a unique molecular compartment for hydrophilic molecules with low interfacial tension.
Correcting image distortions from a nonlinear B1+$$ {\boldsymbol{B}}_{\mathbf{1}}^{+} $$‐gradient field in frequency‐modulated Rabi‐encoded echoes
Authors: Wang Paul , Froelich Taylor , Torres Efraín , DelaBarre Lance , Jenkins Parker , Radder Jerahmie , Mullen Michael , Garwood Michael 
Published: December 2022

PurposeTo correct image distortions that result from nonlinear spatial variation in the transmit RF field amplitude () when performing spatial encoding with the method called frequency‐modulated Rabi encoded echoes (FREE).Theory and MethodsAn algorithm developed to correct image distortion resulting from the use of nonlinear static field (B0) gradients in standard MRI is adapted herein to correct image distortion arising from a nonlinear ‐gradient field in FREE. From a ‐map, the algorithm performs linear interpolation and intensity scaling to correct the image. The quality of the distortion correction is evaluated in 1.5T images of a grid phantom and human occipital lobe.ResultsAn expanded theoretical description of FREE revealed the symmetry between this ‐gradient field spatial‐encoding and standard B0‐gradient field spatial‐encoding. The adapted distortion‐correction algorithm substantially reduced image distortions arising in the spatial dimension that was encoded by the nonlinear gradient of a circular surface coil.ConclusionImage processing based on straightforward linear interpolation and intensity scaling, as previously applied in conventional MRI, can effectively reduce distortions in FREE images acquired with nonlinear ‐gradient fields.
Investigation and analysis of status of mechanical prevention of venous thrombosis in ICU
Authors: Xiaoxiao Guan , Li Li , Shijin Gong , Yueben Wang , Junhai Zhen 
Published: December 2022

AbstractAimsThe presented paper aims at understanding the current situation of mechanical prevention of venous thrombosis in ICU.DesignA questionnaire survey.MethodsA self‐developed Questionnaire on the Current Situation of VTE Mechanical Prevention in ICU was distributed.ResultsA total of 125 valid questionnaires were collected. The results shows that only 11.2% ICUs had the ratio of mechanical prevention equipment to the bed number ≥0.8:1; there was significant differences among ICU nurses in different levels of hospitals in mastering the indications, contraindications and use process of venous thromboembolism mechanical prevention; 42 ICUs (33.6%) used disposable leg covers for patients before the use of mechanical prevention equipment. The face‐to‐face teaching model was the main method adopted in the education and training of mechanical prevention.
Atmospheric water harvesting with scale‐up potentials using natural sunlight and passive cooling
Authors: Li Chunfeng , Pan Quanwen , Ying Wenjun , Shan He , Wang Ruzhu , Zhang Hua , Wang Jiayun 
Published: December 2022

AbstractSorption‐based atmospheric water harvesting (SAWH) is a promising technology that can potentially alleviate global shortages of water, especially in arid regions. However, current SAWH devices are difficult to scale up and exhibit significant disadvantages in terms of their cost, portability and efficiency. Herein, we report a portable and efficient atmospheric water‐harvesting device with scalable and low‐cost high‐performance lithium‐containing membrane‐encapsulated composite sorbents. We use the thermodynamic framework for moist air states to develop the device with a structure featuring hollow insulation grid that harnessed the large temperature difference between the sorbent and the condenser, and thus, the water yield of SAWH device was increased by 20.5%. In outdoor experiments, it achieved an ultra‐high water productivity of 34.8 gwater/kgdevice and 1399.28 gwater/(m2 day) and an exceptionally low water‐extraction cost of $2.65/kgwater per cycle. Thus, this scalable and efficient passive SAWH device demonstrates the possibility of achieving low‐cost and reliable water production in real scenarios and paves the way for practical applications of SAWH.Key points
Water harvesting
cost‐efficient sorbent
Heat and moisture transfer optimization
Utilization of an ITP quality improvement pathway improves adherence to management guidelines
Authors: Harris Emily M. , Hillier Kirsty , Nolan Michaela , Meleedy‐Rey Patricia , Buissereth Taylah , Grace Rachael F. 
Published: December 2022

AbstractDespite availability of epidemiologic studies and national guidelines for the management of newly diagnosed pediatric immune thrombocytopenia (ITP), practice variation exists among and within hematology practices. We previously described the development of an ITP pathway guiding management based on bleeding symptoms. Over an 8‐year period, integration of this iterative ITP pathway into management of newly diagnosed ITP increased observation rates in children with no or mild bleeding symptoms and improved consistency of laboratory evaluation and treatment strategies without increasing adverse outcomes. This quality improvement initiative has been sustainable, acceptable to providers, and increased adherence to guidelines.
Metastatic rhabdomyosarcoma with exclusive distant lymph node involvement: A European Pediatric Soft tissue sarcoma Study Group (EpSSG) report
Authors: Mercolini Federico , Merks Johannes H. M. , Minard‐Colin Veronique , Cameron Alison , van Scheltinga Scheila E. J. Terwisscha , Sher Osnat , Fichera Giulia , Orbach Daniel , Glosli Heidi , Coppadoro Beatrice , Gallego Soledad , Chisholm Julia C. , Bisogno Gianni 
Published: December 2022

AbstractBackgroundThe prognosis of patients with metastatic rhabdomyosarcoma (RMS) is not uniformly poor. Tumors with nodal involvement beyond the first lymph node station are currently considered to have distant metastases. The aim of this study is to evaluate the characteristics and outcome of RMS patients with distal nodal involvement as the only site of metastasis.MethodsThis study included all patients with a diagnosis of RMS and distant nodal involvement as the only metastatic site, enrolled in the European Pediatric Soft tissue sarcoma Study Group (EpSSG) protocols. Treatment comprised chemotherapy, surgery, and/or radiotherapy. The main outcome measures were event‐free survival (EFS) and overall survival (OS).ResultsA total of 22 patients (median age 7.1 years, range 1.4–16.7) fit the inclusion criteria. The extremities were the most common primary tumor site (59%). Twenty‐one patients had regional and distant nodal involvement, 12 were PAX3/7‐FOXO1 positive. Twenty patients had radiotherapy including 16 to the nodal metastatic area. After a median follow‐up of 53.9 months (range 22.8–110.5), 15 patients remain in complete remission, seven had progressive disease or relapse, and six of them died. The 3‐year EFS and OS were 67.1% (95% confidence interval [CI]: 42.9–82.9) and 71.9% (95% CI: 47.7–86.3), respectively. Patients with fusion‐negative tumors had better outcomes than those with fusion‐positive tumors (3‐year EFS 100% vs. 46.6%; p = .04).ConclusionIn our experience, patients with RMS and distant lymph node involvement as the only site of metastasis present an outcome superior than other metastatic patients and comparable to patients with locoregional nodal involvement. In particular, excellent outcomes were seen in the limited number of patients with fusion‐negative tumors.
Essential Role of Destructive Interference in the Gravitationally Induced Entanglement
Authors: Rostom Aiham M. 
Published: December 2022

AbstractThe gravitationally induced entanglement is a type of quantum entanglement that can be generated between two mesoscopic particles using their Newtonian gravitational interaction. It has attracted a great deal of attention as a new platform for studying quantum aspects of gravity. The present paper analyzes the gravitationally induced entanglement as a pure interference effect and shows that the entanglement is induced solely by a sign change associated with the destructive quantum interference. It is also shown that when the entanglement is non‐maximal, the preparation for destructive interference for one of the particles can recover a maximum visibility interference pattern for the other particle. Therefore, the non‐maximally entangled state can be extremely effective for experimental testing since it can help in reducing requirements (on masses of the particles and their interaction duration, separation distances and sources) and preserve the information about entanglement at the same time. As a result, the improvement in the signal‐to‐noise ratio is demonstrated and a parameter that determines minimal requirements for experimental testing is defined.
Sustainable value in the fashion industry: A case study of value construction/destruction using digital twins
Authors: Wagner Ralf , Kabalska Agnieszka 
Published: December 2022

AbstractNew technologies—especially the emergence of digital fashion and a growing interest in creating digital twins (DTs)—are expected to alter existing value chains in the fashion industry as DT technology triggers a redesign of value creation processes. This qualitative case study demonstrates how and to what extent the development of DTs in the fashion industry addresses the sustainability needs of various stakeholders in both real‐world and virtual‐reality settings. The article examines the possibilities, benefits, and challenges of creating sustainable value in two distinct ways: traditionally, through physical processes, and through digital transformation by employing virtual processes via DTs. The main implication for further research is to examine the distribution of value facilitated by DT among heterogeneous stakeholders.
Designing Nanofluidic Diode from a Hybrid‐Bilayer Covalent Organic Framework: Molecular Simulation Investigation
Authors: Wang Mao , Jiang Jianwen 
Published: December 2022

AbstractNanofluidic diodes are potentially useful in many important applications such as sensing, electronics, and energy conversion. However, the manufacturing of controllable nanopores for nanofluidic diodes is technically challenging. Herein, a nanofluidic diode is designed from a highly programmatic covalent organic framework (COF). Through molecular simulation, remarkable diode behavior is observed in a hybrid‐bilayer COF but not in its constituent single‐layer COFs. The rectification effect of ion current in the hybrid‐bilayer COF is attributed to an asymmetric electrostatic potential across the COF nanopore. Furthermore, a synergistic effect of counterion is unraveled in the hybrid‐bilayer COF, and the presence of counterion is found to reduce the entry barrier and facilitate ion transport. The performance of the hybrid‐bilayer COF as a nanofluidic diode is comprehensively investigated by varying salt concentration, layer number, interlayer spacing, and slipping. This proof‐of‐concept simulation study demonstrates the feasibility of the hybrid‐bilayer COF as a nanofluidic diode and the finding may stimulate the development of new nanofluidic platforms.
Effects of the tensile strength and elastic modulus of low‐strength brick aggregate concrete on the ultimate shear strength of short reinforced concrete columns
Authors: Matsukawa Kazuto , Amin A. F. M. S. , Nakano Yoshiaki 
Published: December 2022

AbstractUltimate shear strength of reinforced concrete columns made with low‐strength brick aggregate concrete (BAC) is estimated using Mohr's circle and relevant failure criterion. Compressive tests and splitting tensile tests on concrete cylinders show that the material properties of BAC are distinctly different from those of stone aggregate concrete (SAC). In contrast to the well‐known dependence between the splitting tensile strength and the square root of the compressive strength of concrete, a linear relationship between the splitting tensile strength and the compressive strength is proposed for BAC. The splitting tensile strength of BAC was lower than that of SAC of the same grade when the concrete compressive strength was below 25 MPa. Independent of the concrete strength, the elastic modulus of BAC was 70% of that calculated with the ACI code equation and 50% of that of SAC of the same grade. Twenty‐six column specimens under constant vertical and cyclic horizontal loads are cited from a preliminary report of this research group (see Kabir et al. (2020)) for comparison with the estimated shear strength. A column specimen made with 13.0 MPa BAC exhibited a lower shear strength than that made with a similar grade of SAC. In the 22–23 MPa compressive strength range no distinct difference was observed. The difference in the tested shear strength originates from the distinct differences in the elastic modulus and splitting tensile strength.
BCFT in a black hole background: an analytical holographic model
Authors: Geng Hao , Randall Lisa , Swanson Erik 
Published: December 2022

Abstract
We study the entanglement phase structure of a holographic boundary conformal field theory (BCFT) in a two-dimensional black hole background. The bulk dual is the AdS3 black string geometry with a Karch-Randall brane. We compute the subregion entanglement entropy of various two-sided bipartitions to elucidate the phase space where a Page curve exists in this setup. We do fully analytical computations on both the gravity side and the field theory side and demonstrate that the results precisely match. We discuss the entanglement phase structure describing where a Page curve exists in this geometry in the context of these analytical results. This is a useful model to study entanglement entropy for quantum field theory on a curved background.
Developing a harmonic sustainable public procurement framework
Authors: Lozano Rodrigo , Santos Felippe , Barreiro-Gen Maria 
Published: December 2022

AbstractSustainability is aimed at addressing the environmental and socio-economic issues of this generation and future ones. In this context, sustainable public procurement (SPP) has been proposed to link the consumption side (government) to the production side (companies), whilst addressing the four dimensions of sustainability (economic, environmental, social, and time). This paper undertakes an analysis, through hermeneutics, of four sets of system elements of SPP: (1) demand-offering, which includes products, services, and their combination; (2) procurement specifications (technical, non-technical, and socio-cultural); (3) stakeholder interactions; and, (4) research disciplinary approaches. The analysis shows that despite most SPP efforts focussing on demand-offerings or specifications, there have been some framework proposals aimed at explaining the complexities and interactions between the system elements. Additionally, most research on SPP has been carried out through single disciplinary approaches. The paper proposes the Harmonic SPP framework, which integrates the demand-offering, specifications, stakeholder interactions, disciplinary approaches, and the four sustainability dimensions, where the harmonisation of their interrelations is sine qua non. The Harmonic SPP framework is aimed at providing a more holistic perspective to SPP and thus fostering more effective and efficient SPP research and implementation.
“Attending lectures in your pyjamas”: student agency in constrained circumstances
Authors: Ajjawi Rola , Fischer Juan , Tai Joanna , Bearman Margaret , Jorre de St Jorre Trina 
Published: December 2022

Abstract
COVID-19 forced the digitalisation of teaching and learning in a response often described as emergency remote teaching (ERT). This rapid response changed the social, spatial, and temporal arrangements of higher education and required important adaptations from educators and students alike. However, while the literature has examined the constraints students faced (e.g. availability of the internet) and the consequences of the pandemic (e.g. student mental health), students’ active management of these constraints for learning remains underexplored. This paper aims to “think with” COVID-19 to explore student agency in home learning under constrained circumstances. This qualitative study used semi-structured interviews to understand the day-to-day actions of nineteen undergraduate students managing their learning during the COVID-19 lockdowns in Victoria, Australia. Emirbayer and Mische’s multiple dimensions of agency — iterative, projective, and practical-evaluative — are used to explore student experience. The findings illustrate students’ adaptability and agency in navigating life-integrated learning, with most of their actions oriented to their present circumstances. This practical evaluative form of agency was expressed through (1) organising self, space, time, and relationships; (2) self-care; and (3) seeking help. Although this study took place in the context of ERT, it has implications beyond the pandemic because higher education always operates under constraints, and in other circumstances, many students still experience emotionally and materially difficult times.
Renewing the Sydney undergraduate curriculum
Authors: Pattison Philippa , Bridgeman Adam , Bulmer Ainslie , McCallum Peter , Miles Richard 
Published: December 2022

AbstractA number of commentators have recently called for a re-examination of the purpose and value of undergraduate education, arguing that change is required if universities are to deliver the value in educational outcomes that students and communities now require for a changing and challenging world (for example, Aoun, 2017; Bok, 2020; Davidson, 2017; Fischman & Gardner, 2022). Indeed, some have argued that such change is necessary to stem an emerging crisis in universities’ ‘social license to operate’ (Bok, 2020). In this paper, we review the case for undergraduate curriculum change and present a case study of one Australian university’s engagement with this challenge, describing the reasons for change, the desired outcomes, and some early impacts on students’ study patterns. The change took place at the University of Sydney over the period from 2014 to 2021 with a new undergraduate curriculum introduced for commencing students from 2018. Intended to prepare students for a changing world, the new curriculum sought a balance between graduates’ expertise in a primary field of study and a set of broader capabilities that would support their capacity for future learning and for creative and effective engagement in life and career, including an understanding of broader intellectual landscapes; the skills for collaboration, invention, and influence; and the integration of knowledge with professional and personal ethics and values. The aspiration to develop such capabilities is shared with many universities around the world, and we describe here how the available evidence base was used to guide whole-of-University curriculum redesign in this case. We also identify areas where further research would be of value.
Consent Codes: Maintaining Consent in an Ever-expanding Open Science Ecosystem
Authors: Dyke Stephanie O. M. , Connor Kathleen , Nembaware Victoria , Munung Nchangwi S. , Reinold Kathy , Kerry Giselle , Mbiyavanga Mamana , Zass Lyndon , Moldes Mauricio , Das Samir , Davis John M. , De Argila Jordi Rambla , Spalding J. Dylan , Evans Alan C. , Mulder Nicola , Karamchandani Jason 
Published: December 2022

AbstractWe previously proposed a structure for recording consent-based data use ‘categories’ and ‘requirements’ – Consent Codes – with a view to supporting maximum use and integration of genomic research datasets, and reducing uncertainty about permissible re-use of shared data. Here we discuss clarifications and subsequent updates to the Consent Codes (v4) based on new areas of application (e.g., the neurosciences, biobanking, H3Africa), policy developments (e.g., return of research results), and further practical considerations, including developments in automated approaches to consent management.