bluuebunny/crossref_metadata_2025_split huggingface dataset:
Interventions for expectant and new parents who are at increased risk for perpetrating child abuse and neglect: Protocol for a systematic review and meta-analysis
Authors: Tamon Hiroki , Suto Maiko , Ogawa Kunio , Takehara Kenji , Tachibana Yoshiyuki 
Published: August 2022

Abstract
Introduction: The prevention of child abuse and neglect is an urgent matter given the serious effects of abuse and neglect persisting into adulthood, and the increased risk of the offspring of abused children being abusive themselves. Intervening as early as possible may prevent abuse that can begin in infancy. Although several systematic reviews and meta-analyses have investigated the effects of interventions on populations who are at increased risk for perpetrating child abuse and neglect, few studies have focused on women who are at increased risk for perpetrating child abuse and neglect or interventions that start during perinatal periods. This study aims to describe a systematic review to examine the effects of interventions to prevent child abuse and neglect that begin during pregnancy and immediately after childbirth (less than one year). The study will involve performing a systematic review and meta-analysis based on the latest research articles and a broader literature search.Methods and analysis: The protocol was prepared using the 2015 statement of Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols. The review will follow Preferred Reporting Items for Systematic Review and Meta-Analysis guidelines. The literature search will be performed using the MEDLINE, PsycINFO, Embase, and Cochrane Central Register of Controlled Trials databases from inception onward. Randomized controlled trials of interventions that begin during pregnancy or the first year postpartum, designed to prevent child abuse and neglect in families who are at increased risk for these issues, will be included. Data collection, quality assessment, and statistical syntheses will be conducted by following the methods in the protocol that are predefined.Ethics and dissemination:This study does not require ethical approval. The findings will be presented at conferences and will be submitted to a peer-reviewed journal.Systematic review registration: PROSPERO CRD42021266462Strengths and limitations of this study- This study will systematically review and analyze evidence on the effectiveness of interventions to prevent child abuse and neglect among pregnant and postpartum women. - This study will investigate a broader range of electronic bibliographic databases, including MEDLINE, PsycINFO, Embase, and CENTRAL, using a systematic search strategy.- The study will be based on the latest articles, and the publication period will not be limited.- As we will only include peer-reviewed articles written in English, a publication bias may occur that excludes related research published in other languages and gray literature. - We will only access limited databases, and furthermore, using different methods to assess child abuse and neglect may cause heterogeneity among studies.
Effects of different low temperature conditions on anaerobic digestion efficiency of pig manure and composition of archaea community
Authors: Gu Shiyan , Wang Ruji , Xing Huige , Yu Mingzhe , Shen Siyu , Zhao Liang , Sun Jiyang , Li Yi 
Published: August 2022

Abstract
To explore the effect of low temperature on the anaerobic digestion of pig manure, the anaerobic digestion experiment was carried out under the conditions of inoculum concentration of 30% and TS of 8%. Five low-temperature gradients of 4, 8, 12, 16 and 20 °C were set to study the activities of gas production, pH, solluted chemical oxygen demand (SCOD), volatile fatty acids (VFAs), coenzymes F420 and archaea community composition in the digestion process. The results were demonstrated: as the temperature decreased, the more unstable the gas production became, the less gas production produced, and the later the gas peak occurred. There were no significant peaks at either 4 °C or 8 °C, and the SCOD was unstable over time. From 12 °C, the SCOD increased over time, and the higher the temperature, the faster the growth trend. The pH was always greater than 7.6. 8, 12, 16, 20 °C had different degrees of VFAs accumulation at the late digestion stage. The higher the temperature, the greater the amount of volatile acid accumulation. When the VFAs of each reactor reached the maximum, the proportion of acetic acid also reached the highest. The digestion system of the five treatment groups was dominated by hydrogen-nutrient methanogenic pathway. The results could provide a further reference for the mechanism of anaerobic digestion of pig manure at low temperatures.
Levantamento da Mirmecofauna em Fragmentos de uma Área de Proteção Ambiental em Caxias, Maranhão- Brasil
Authors: De Sousa Martins Alana Ellen , Rodrigues da Silva Maria Juciele , Rodrigues Judson Chaves , De Alencar Costa Silva Maira Rebeca , Pereira Gonçalves Márcia Verônica , Araújo da Silva Formiga Luiza Daiana , Franco Cleilton Lima 
Published: August 2022

As formigas apresentam diversas características que podem ser utilizadas em estudos de biodiversidade, monitoramento, fragmentação e ecologia de ecossistemas. O presente trabalho tem o objetivo contribuir para o melhor entendimento da dinâmica e biodiversidade da fauna de formigas em dois fragmentos na Área de Proteção Ambiental do Inhamum. O estudo aconteceu em duas áreas de Cerrado na APA do Inhamum. As armadilhas foram distribuídas na duas áreas, em cada área com trinta unidades amostrais. As coletas foram realizadas nos meses de: setembro à dezembro de 2017 e janeiro à março de 2018. Para a coleta do material foram utilizadas armadilhas do tipo Provid. Para as análises estatísticas os dados foram submetidos a análises faunísticas, realizados no programa ANAFAU. As estimativas de riqueza Chao1 e Chao2 foram realizadas com o auxílio do programa R. Foram contabilizados um total de 1.845 indivíduos distribuídos em 29 gêneros, sendo 22 para Área I, sendo 11 gêneros exclusivos e 18 gêneros para Área II, sendo 7 gêneros exclusivos para esta área. A curva de acumulação das duas áreas não se apresentou estável mostrando assim que seria preciso um maior esforço amostral para atingir o equilíbrio.
Information Content Assessment of the Federal Budget and the Budget Process in the Russian Federation
Authors: Morozov O. V. , Vasiliev M. A. 
Published: August 2022

This article is devoted to the results of a statistical study of the composition of federal budget expenditures (the object of the study) from the standpoint of assessing its information content (the subject of the study). In the opinion of its authors, the issues of information content of budget decisions remain out of due attention not only from the participants of the budget process, but also in the practice of public administration in general. Therefore, the purpose of this study is to form scientifically based tools for assessing the information content, determining its quantitative indicators, clarifying the nature, hidden features and balance in the distribution of federal budget expenditures.Materials and methods. The analysis of the composition parameters of federal budget expenditures was carried out on the basis of statistical data of the Federal Treasury for 2014-2020. The theoretical foundations and research methods are developed based on the authors’ preferences regarding the results of conceptual and applied developments of domestic scientists in the field of synergetic information theory, structural analysis of systems, and modular theory of society. Quantitative methods of processing the initial data, tabular and graphical methods of visualizing the results of the study were used. Standard Microsoft Office application software packages were used to solve the research tasks.Results. Indexes of information content of the multicomponent systems’ composition and algorithms for their calculations are formed. Quantitative criteria are determined and a model for optimizing the composition of federal budget expenditures is presented. The comparison of actual and model indexes of the information content is presented as a way to adjust priorities in the composition of federal budget expenditures; as a way to develop tactics and strategies for the transition from the actual parameters of the expenditures’ composition to the “best” distribution, which is described by a quantitative model of the optimal combination of the scales of its components. Retrospective optimization options based on the results of the execution of expenditures in 2020 and promising options for optimizing the distribution of federal budget expenditures in 2022-2024 have been established.Conclusion. Assessment of the information content and optimization of the components’ scale of the budget expenditures’ composition are recognized as elements of management of the distribution of public resources in the budget process, ways to ensure control over the effectiveness of budget decisions and can be useful for participants in the budget process both at the stage of formation and at the stage of execution of budget expenditures.
Nano/Microcarriers in Drug Delivery: Moving the Timeline to Contemporary
Authors: Nikezić Ana Vujačić , Novaković Jasmina Grbović 
Published: August 2022

Abstract:
Treatment of various diseases, especially cancer treatment, includes the potential
use of different types of nanoparticles and nanostructures as drug carriers. However,
searching for less toxic and more efficient therapy requires further progress, wherein recent
developments in medicine increasingly include the use of various advanced nanostructures.
Their more successful application might be achieved by leveling imbalances between
the potentiality of different nanostructures and the demands required for their safe
use. Biocompatibility, biodegradability, prolonged circulation time and enhanced accumulation
and uptake by cells are some of the key preconditions for their usage in efficient
drug delivery. Thanks to their greatly tunable functions, they are major building
blocks for manufacturing novel materials. Nevertheless, given that their toxicity is questionable,
their practical application is challenging. Hereof, before entering the sphere of
human consumption, it is of critical importance to perform more studies regarding their
toxicity and drug distribution. This review emphasizes recent advances in nanomedicine,
employing different kinds of conventionally used nanoparticles as well as novel nanoparticles
and nanostructures. Special emphasis is placed on micro/nanomotors (MNMs), discussing
their opportunities, limitations, challenges and possible applications in drug delivery
and outlining some perspectives in the nanomedicine area.
Bioprinting: From Technique to Application in Tissue Engineering
and Regenerative Medicine
Authors: de Souza Thaís Vieira , Pastena Giorno Luciana , Malmonge Sonia Maria , Santos Arnaldo R. 
Published: August 2022

Abstract:
Among the different approaches present in regenerative medicine and tissue
engineering, the one that has attracted the most interest in recent years is the possibility
of printing functional biological tissues. Bioprinting is a technique that has been applied
to create cellularized three-dimensional structures that mimic biological tissues and thus
allow their replacement. Hydrogels are interesting materials for this type of technique.
Hydrogels based on natural polymers are known due to their biocompatible properties,
in addition to being attractive biomaterials for cell encapsulation. They provide a threedimensional
aqueous environment with biologically relevant chemical and physical
signals, mimicking the natural environment of the extracellular matrix (ECM). Bioinks are
ink formulations that allow the printing of living cells. The controlled deposition of
biomaterials by bioinks needs to maintain cell viability and offer specific biochemical and
physical stimuli capable of guiding cell migration, proliferation, and differentiation. In this
work, we analyze the theoretical and practical issues of bioprinting, citing currently used
methods, their advantages, and limitations. We present some important molecules that
have been used to compose bioinks, as well as the cellular responses that have been
observed in different tissues. Finally, we indicate future perspectives of the method.
Comparison of R1ρ Imaging Between Rapid Acquisition with Relaxation
Enhancement (RARE) and Ultrashort TE (UTE) Sequence in the Assessment
of Rat Liver Iron Overload at 11.7T
Authors: Wang Qianfeng , Liu Ying , Xiao Hong , Yan Fuhua , Wang He 
Published: August 2022

Introduction::
Since the most prominent effect of iron is increasing R2* and R2 relaxation
rates, the iron-overload liver shows little signal with conventional T1ρ sequences like RARE. Whereas
UTE MR imaging sequences can detect the signal from short T2/T2* relaxation components in tissues.
This study aims to evaluate the difference in R1ρ profiles and compare the correlations between
RARE-based and UTE-based sequences with LIC in assessing rat liver iron overload.

Methods::
Iron dextran (Sigma, 100 mg Fe/ml) was injected into thirty-five rats (25-100 mg/kg body
weight), while the rats in the control group were injected with saline (n=5). The liver specimen was
taken after one week. A portion of the largest hepatic lobe was extracted to quantify the LIC by inductively
coupled plasma, and the remaining liver tissue was stored in 4% buffered paraformaldehyde for
24 h before MRI. Spin-lock preparation with RARE readout and 2D UTE readout pulses were developed
to quantify R1ρ on a Bruker 11.7T MR system.

Results::
The mean R1ρ value of the rat liver with UTE-based R1ρ sequence was significantly higher
compared to the RARE-based R1ρ sequence (p<0.001). Spearman’s correlation analysis (two-tailed)
indicated that the R1ρ values were significantly correlated with LIC for both UTE-R1ρ and RARER1ρ
sequences (r = 0.727, P < 0.001, and r = 0.712, P < 0.001, respectively).

Conclusion::
The current study adds to evidence that there is a correlation between iron concentration
and R1ρ. Moreover, the UTE-based R1ρ sequence is more sensitive to the liver iron than the RAREbased
R1ρ sequence. R1ρ might serve as a complementary imaging biomarker for liver iron overload
quantification.
QSAR Study of Novel 1, 8-Naphthimide Derivatives Targeting Nuclear DNA
Authors: Tai Yunheng , Lian Zheng , Xia Huanling , Zhai Honglin 
Published: August 2022

Background::
1, 8-naphthimide is a novel tumor inhibitor targeting nuclear DNA, which can be used to
design and develop anti-osteosarcoma drugs.

Objective::
Quantitative structure-activity relationship (QSAR) model was established to predict the physical properties
of compounds.

Method::
In this study, gene expression programming (GEP) was used to build a nonlinear quantitative structureactivity
relationship (QSAR) model with descriptors and to predict the activity of a serials novel DNA-targeted chemotherapeutic
agents. These descriptors were calculated in CODESSA software and selected from the descriptor pool
based on heuristics. Three descriptors were selected to establish a multiple linear regression model. The best nonlinear
QSAR model with a correlation coefficient of 0.89 and 0.82 and mean error of 0.02 and 0.06 for the training and test
sets were obtained.

Result::
The results showed that the model established by GEP had better stability and predictive ability. The small
molecular docking experiment of 32 compounds was carried out in SYBYL software, and it was found that compound
7A had reliable molecular docking ability.

Conclusion::
The established model reveals the factors affecting the activity of DNA inhibitors and provides direction
and guidance for the further design of highly effective DNA-targeting drugs for osteosarcoma.
Multidisciplinary Rehabilitation Approach to the Maxillo-Facial Complications of Crouson’s Disease: Case Report and Review
Authors: Zaki Hattan A. , Alassaf Muath Saad , Babkair Hamzah Ali , Abdel-Latif Ghada A. , Jaffar Abdulrahman Khaled , Alolayan Albraa B. , Elsayed Shadia Abdel-Hameed 
Published: August 2022

Background:Craniofacial anomalies present a challenge to all health care practitioners since they necessitate long-term team follow-up, which is difficult to achieve outside of a major center where craniofacial anomalies teams normally collaborate.Objectives:The current review with an illustrative case focuses on the representation and review of Crouzon syndrome and its maxillofacial implications. Review of different varieties of gene mutations that produce craniosynostosis syndromes were discussed and focused on seven clinically distinct craniosynostosis syndromes that are precipitated by the mutation in one or more of the fibroblast growth factor receptors genes which affected the maxillofacial region.Case presentation:A complete clinical and radiographic case scenario of a patient suffering from Crouzon syndrome was presented, and discussion of the various disciplines and techniques used along the way to achieve the best results, as well as how team collaboration and patient compliance led to the best results were represented. The presented case was treated with orthodontic treatment, Le Fort-I osteotomy, and Le Fort-III osteotomy with extraoral distraction osteogenesis.Conclusion:The combination of different orthognathic surgery alternatives (Le Fort-III and Le Fort-I) with distraction osteogenesis and orthodontic treatment produced excellent outcomes with few complications, and the patient was extremely satisfied and cooperative. Early and thorough team-based care for Crouzon syndrome patients should be accessible at specialized craniofacial centers.
Assessment of Hygiene Behavior and Associated Factors Among School Children in Shey Bench, Southwest, Ethiopia. An Institutional Based-Cross Sectional Study
Authors: Beya Mogos , Agegnehu Wubetu , Shinde Sanjay Sukumar 
Published: August 2022

Introduction:
In underdeveloped countries, such as Ethiopia, the impact of disease burden caused by inadequate, contaminated water and a lack of sanitation is a huge burden. Water and sanitation-related infections are still a high-risk habit among primary school-aged children. As a reason, the objective was to analyze hygiene behavior and associated factors among school children in Shey Bench, Southwest Ethiopia, during the 2018/19 school year.

Methods:
An institutional-based descriptive cross-sectional study was done in 2019 to collect data from 770 primary school students in grades 5th through 8th from January 1 to 30, 2019. Data were entered into Epi data 4.2 and then analyzed in SPSS V. 21.0. Multivariate logistic regression analysis was used to identify independent factors of hygienic behavior.

Results:
In this study area, 34.1 percent of school students have good hygiene behavior. Being female students (AOR=2.68), Urban residency (AOR=1.86), having poor hand-washing knowledge (AOR=0.148), lack of availability of hand-washing facility (AOR=0.541), separate toilet for male and female (AOR=2.11), no read and write father's educational status (AOR=0.314) and presence of clubs in the school (AOR=1.75) were all significantly associated with hygienic behavior

Conclusion:
In general, there is a poor hygiene. Urban residency, no read and write father's educational status, existence of sanitation club in schools, having separate toilets for boys and girls, having hand washing available in the facility, and having poor knowledge of hand washing were all substantially associated to hygienic behavior.
Wearables for Measuring the Physical Activity and Sedentary Behavior of Patients With Axial Spondyloarthritis: Systematic Review
Authors: Soulard Julie , Carlin Thomas , Knitza Johannes , Vuillerme Nicolas 
Published: August 2022

BackgroundAxial spondyloarthritis (axSpA) is an inflammatory rheumatic disease associated with chronic back pain and restricted mobility and physical function. Increasing physical activity is a viable strategy for improving the health and quality of life of patients with axSpA. Thus, quantifying physical activity and sedentary behavior in this population is relevant to clinical outcomes and disease management. However, to the best of our knowledge, no systematic review to date has identified and synthesized the available evidence on the use of wearable devices to objectively measure the physical activity or sedentary behavior of patients with axSpA.ObjectiveThis study aimed to review the literature on the use of wearable activity trackers as outcome measures for physical activity and sedentary behavior in patients with axSpA.MethodsPubMed, PEDro, and Cochrane electronic databases were searched in July 2021 for relevant original articles, with no limits on publication dates. Studies were included if they were original articles, targeted adults with a diagnosis of axSpA, and reported wearable device–measured physical activity or sedentary behavior among patients with axSpA. Data regarding the study’s characteristics, the sample description, the methods used for measuring physical activity and sedentary behavior (eg, wearable devices, assessment methods, and outcomes), and the main results of the physical activity and sedentary behavior assessments were extracted.ResultsA total of 31 studies were initially identified; 13 (13/31, 42%) met the inclusion criteria, including 819 patients with axSpA. All the studies used accelerometer-based wearable devices to assess physical activity. Of the 13 studies, 4 (4/31, 31%) studies also reported outcomes related to sedentary behavior. Wearable devices were secured on the wrists (3/13 studies, 23%), lower back (3/13, 23%), right hip (3/13, 23%), waist (2/13, 15%), anterior thigh (1/13, 8%), or right arm (1/13, 8%). The methods for reporting physical activity and sedentary behavior were heterogeneous. Approximately 77% (10/13) of studies had a monitoring period of 1 week, including weekend days.ConclusionsTo date, few studies have used wearable devices to quantify the physical activity and sedentary behavior of patients with axSpA. The methodologies and results were heterogeneous, and none of these studies assessed the psychometric properties of these wearables in this specific population. Further investigation in this direction is needed before using wearable device–measured physical activity and sedentary behavior as outcome measures in intervention studies in patients with axSpA.Trial RegistrationPROSPERO CRD42020182398; https://tinyurl.com/ec22jzktInternational Registered Report Identifier (IRRID)RR2-10.2196/23359