bluuebunny/crossref_metadata_2025_split huggingface dataset:
Oral and fecal microbiota in patients with diarrheal irritable bowel syndrome
Authors: Tang Binbin , Hu Yunlian , Chen Jianhui , Su Chengxia , Zhang Qian , Huang Chaoqun 
Published: June 2022

Abstract

Background: This study aimed at investigating the characteristics and correlation between oral (tongue coating) and fecal microbiota in patients with diarrheal irritable bowel syndrome (IBS-D). Methods: Fifty-two IBS-D patients were chosen, with ten healthy volunteers serving as the normal control group. Tongue coating samples and fecal samples of subjects were sequenced for the 16S rRNA gene (V4-V5). Bioinformatics analysis was done on the test data to investigate oral and fecal microbiota composition characteristics in IBS-D patients. Results: The microbial richness of tongue coating in IBS-D group was lower than that in the normal control group (P < 0.05). The beta diversity of tongue coating microbiota and fecal microbiota was significantly different in the IBS-D group compared to the normal control group (P < 0.05). Pseudomonadales (Pseudomonadaceae and Pseudomonas), Moraxellaceae, Parvimonas, Peptostreptococcus, and Alloprevotella were considerably high in number the tongue coating samples of the IBS-D group in comparison to the normal control group. Similarly, the fecal samples from the IBS-D group were significantly enriched in Alphaproteobacteria, Pseudomonadales (Pseudomonadaceae and Pseudomonas), Acidaminococcaceae, Phascolarctobacterium, Alloprevotella, and Escherichia compared to the normal control group. Conclusions: The oral and fecal microbiotas of IBS-D patients differ considerably from those of the control group; hence studying IBS-D from the perspective of the oral-gut microbiome axis is an interesting research avenue.
Microsatellite markers for 24 loci developed for genotyping eastern woodrats, Neotoma floridana
Authors: ATHERTON TIFFANIE B. , HEIST EDWARD J. , NIELSEN CLAYTON K. 
Published: June 2022

Abstract
Population declines have been documented in many species within the genus Neotoma. Eastern woodrat, Neotoma floridana, recovery efforts in the Shawnee National Forest (SNF), Illinois USA provided an opportunity to study the long-term population-level genetic changes following an augmentation and reintroduction. We developed 24 microsatellite markers using QDD and genotyped 32 eastern woodrats from a single population. Number of alleles per locus ranged from 3-14 (mean = 7). Observed heterozygosity ranged from 0.375–0.969 per locus and expected heterozygosity from 0.485-0.854. Two loci showed significant deviation from Hardy-Weinberg equilibrium following Bonferroni sequential corrections. These markers will provide valuable information useful for studying population dynamics of eastern woodrats and closely-related species.
Global key concepts of civil-military cooperation for disaster management in the COVID-19 pandemic – a qualitative phenomenological scoping review.
Authors: Ries Markus 
Published: June 2022

Abstract
Background: In the context of a holistic and comprehensive disaster response effort to the COVID-19 pandemic, many countries across the globe mobilized their military forces in order to cope with sudden and exponential surges of critically ill patients with COVID-19 in stretched healthcare systems. Objective: The purpose of this work is to identify, map, and render world-wide key concepts of civil-military cooperation (CIMIC) in disaster management during the COVID-19 crisis visible.Material and Methods: Literature was systematically searched in three databases (PubMed, Web of Science, Cochrane Library) on 26 January 2022, and analyzed with qualitative, mixed narrative-phenomenological methods in compliance with PRISM-ScR and SRQR.Results: Forty-five publications were included in the analysis; pertinent authors were from 22 countries covering five continents. We identified three key thematic clusters in the published literature: Cluster 1) Medico-scientific contributions with the participation of military medical personnel or institutions: members of the military acted as subject matter experts, clinical and experimental (co-) investigators as well as co-founders for enabling COVID-19 relevant research. Areas covered were relevant to the COVID-19 patient’s clinical journey from prevention, exposure, diagnostics, and treatment and included pertinent fields such as digital health and telemedicine, global and public health, critical care, emergency and disaster medicine, radiology, neurology, as well as other medical specialties, i.e., respiratory care, pulmonology, burn medicine, and transfusion medicine, in addition to environmental and occupational sciences as well as materials science. Cluster 2) CIMIC field experiences or analyses included areas such as political framework, strategy, structure, nature of civil-military interaction and concrete mission reports in selected countries. Themes covered a broad spectrum of pandemic disaster management subjects such as capacity and surge capacity building, medical and pharmaceutical logistics, patient care under austere circumstances, SARS-CoV-2 testing support, intelligent and innovative information management, vaccination support, and disaster communication. Cluster 3) The military as a role model for crisis management. Conclusion: civil-military cooperation made a significant contribution to the level of resilience in crisis management on a global scale, positively impacting a broad spectrum of core abilities during the COVID-19 pandemic.
Gut Microbiota is Associated with Response to 131I Therapy in Patients with Papillary Thyroid Carcinoma
Authors: Zheng L , Zhang LJ , Tang L , Huang DD , Pan Deng , Guo W , He S , Huang Y , Chen Y , Xiao X , Tang B , Chen J 
Published: June 2022

Abstract
Purpose
Radioactive Iodine (131I) (RAI) therapy is a conventional post-surgery treatment widely used for papillary thyroid carcinoma (PTC). Since 131I is orally administered, we hypothesize that it may affect gut microbiome. This study aims to investigate alterations of intestinal microbiome after 131I therapy in PTC patients and explore its association with response to 131I therapy.
Methods
Fecal samples of 60 PTC patients pre- and post-131I therapy were collected to characterize the RAI-induced gut microbiota alterations using 16S rRNA gene sequencing. Sequence data of 40 out of the 60 patients, divided into excellent response (ER) group and non-excellent response (NER) group, were screened out to investigate the possible connection between gut microbiota and response to 131I. A random forest classifier for 131I response prediction was constructed.
Results
Microbial richness, diversity and composition were tremendously altered after 131I therapy. A significant decline of Firmicutes to Bacteroides (F/B) ratio was observed post-131I therapy. Some different metabolic pathways were found. Furthermore, discrepant β-diversity was found between the ER and NER groups pre- and post-131I therapy. A predictive classifier for response to 131I therapy with an AUC of 75.0% was constructed using four microbial variables-Bifidobacterium, Dorea, Erysipelotrichaceae, as biomarkers of ER and Parabacteroides, as biomarker of NER.
Conclusion
The present study illustrates the gut microbial dysbiosis after 131I therapy in PTC patients for the first time and reveals a previously undefined role of gut microbiome as potential biomarkers for predicting RAI responses.
Establishment of narrow root fracture models using modified temperature cycling method and diagnosis using different cone-beam CT units
Authors: Liang Jiahao , Wang Tiemei , Cao Dantong , Cao Ya , Gao Antian , Xie Xin , Wang Zhiyong , Lin Zitong 
Published: June 2022

Abstract
AimUsing modified thermal cycling method to establish narrow root fracture models and evaluate the diagnosis efficiency of them using four different cone-beam CT (CBCT) units.MethodologyFifty-six intact teeth were selected and the crowns of the teeth were embedded using general purpose acrylic resin. 50 VRF models were established by soaking these teeth in liquid nitrogen and hot water cyclically; 6 teeth were used as negative control. All the 56 teeth were scanned with the smallest voxel size of four different CBCT units (NewTom VGi, Planmeca Promax 3D Max, Kavo 3D eXam and Soredex Scanora3D). The CBCT images were evaluated for the presence or absence of fracture lines. Sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) and area under the receiver operating characteristic curve (AUC) were calculated for the diagnosis of FLs using the four CBCT units. After that, 10 VRF teeth were randomly selected and the roots were sliced using slow-speed saw to obtain horizontal root sections with thickness of 2mm from enamel-cemental junction to the root apex and 25 root sections were finally obtained. Scanning electron microscope (SEM) was used to measure the width of the fracture lines (FLs) for each root section at one side.ResultsFifty narrow root fracture models were successfully established. There were totally 50 positive VRF models with 83 FLs and 6 negative VRF models. The diagnosis sensitivity was 0.24, 0.38, 0.29 and 0.19, the diagnosis specificity was 0.45, 0.16, 0.55, and 0.75, and the AUC was 0.60, 0.52, 0.59 and 0.61 for NewTom VGi, Planmeca Promax 3D Max, Soredex Scanora-3D and Kavo 3D eXam respectively. Randomly selected 10 models were sliced and 25 root sections with 45 FLs were acquired. The width of FLs was from 3.43μm to 143μm; 32.06% were less than 25μm, only 9.6% were from 75 to 150μm with SEM.ConclusionsThe modified temperature cycling method is a simple and effective method to establish narrow root fracture models, the diagnosis efficiency for these narrow fracture lines were quite poor using all the four different CBCT units.
Generation Z's Perception of Fast Food's Product Safety, Nutrition, and Health
Authors: Tahir Nor Suziwana , Ahmad Yarina , Mohammad Reevany Bustami  , Siti Nur Fathanah Abd Hamid  , Muhammad Zamri Nor Ezatie Mukminah , Ratna Mulyany  
Published: June 2022

The rapid growth of the fast food industry is associated with an extravagant trend of fast food consumption, especially among the young generation. This study investigates how Generation Z perceives the key factors to determine fast food's product safety, nutrition, and health. The theory of Stakeholder is employed to explain the responsibility of businesses to their stakeholders and four key factors, including economic, legal, ethical, and philanthropic are adapted from Carroll's CSR pyramid. 330 respondents responded to the survey. The result reveals that the four key factors elicited a significantly positive response to fast food's product safety, nutrition, and health.
Keywords: Generation Z; Fast food; Nutrition; Health
eISSN: 2398-4287 © 2022. The Authors. Published for AMER ABRA cE-Bs by e-International Publishing House, Ltd., UK. This is an open access article under the CC BYNC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). Peer–review under responsibility of AMER (Association of Malaysian Environment-Behaviour Researchers), ABRA (Association of Behavioural Researchers on Asians/Africans/Arabians) and cE-Bs (Centre for Environment-Behaviour Studies), Faculty of Architecture, Planning & Surveying, Universiti Teknologi MARA, Malaysia.
DOI: https://doi.org/10.21834/ebpj.v7i20.3441
Sociotechnical Intervention for Improved Delivery of Preventive Cardiovascular Care to Rural Communities: Participatory Design Approach
Authors: Partogi Michelle , Gaviria-Valencia Simon , Alzate Aguirre Mateo , Pick Nancy J , Bhopalwala Huzefa M , Barry Barbara A , Kaggal Vinod C , Scott Christopher G , Kessler Maya E , Moore Matthew M , Mitchell Jay D , Chaudhry Rajeev , Bonacci Robert P , Arruda-Olson Adelaide M 
Published: June 2022

Background
Clinical practice guidelines recommend antiplatelet and statin therapies as well as blood pressure control and tobacco cessation for secondary prevention in patients with established atherosclerotic cardiovascular diseases (ASCVDs). However, these strategies for risk modification are underused, especially in rural communities. Moreover, resources to support the delivery of preventive care to rural patients are fewer than those for their urban counterparts. Transformative interventions for the delivery of tailored preventive cardiovascular care to rural patients are needed.

Objective
A multidisciplinary team developed a rural-specific, team-based model of care intervention assisted by clinical decision support (CDS) technology using participatory design in a sociotechnical conceptual framework. The model of care intervention included redesigned workflows and a novel CDS technology for the coordination and delivery of guideline recommendations by primary care teams in a rural clinic.

Methods
The design of the model of care intervention comprised 3 phases: problem identification, experimentation, and testing. Input from team members (n=35) required 150 hours, including observations of clinical encounters, provider workshops, and interviews with patients and health care professionals. The intervention was prototyped, iteratively refined, and tested with user feedback. In a 3-month pilot trial, 369 patients with ASCVDs were randomized into the control or intervention arm.

Results
New workflows and a novel CDS tool were created to identify patients with ASCVDs who had gaps in preventive care and assign the right care team member for delivery of tailored recommendations. During the pilot, the intervention prototype was iteratively refined and tested. The pilot demonstrated feasibility for successful implementation of the sociotechnical intervention as the proportion of patients who had encounters with advanced practice providers (nurse practitioners and physician assistants), pharmacists, or tobacco cessation coaches for the delivery of guideline recommendations in the intervention arm was greater than that in the control arm.

Conclusions
Participatory design and a sociotechnical conceptual framework enabled the development of a rural-specific, team-based model of care intervention assisted by CDS technology for the transformation of preventive health care delivery for ASCVDs.
Readiness for Telemedical Services in Patients With Cardiovascular Diseases: Cross-sectional Study
Authors: Kalańska-Łukasik Barbara , Gładyś Aleksandra , Jadczyk Tomasz , Gruz-Kwapisz Monika , Wojakowski Wojciech , Kowalska Malgorzata 
Published: June 2022

Background
Telemedicine solutions, especially in the face of epidemiological emergencies such as the COVID-19 pandemic, played an important role in the remote communication between patients and medical providers. However, the implementation of modern technologies should rely on patients’ readiness toward new services to enable effective cooperation with the physician. Thus, successful application of patient-centric telehealth services requires an in-depth analysis of users’ expectations.

Objective
This study aimed to evaluate factors determining readiness for using telehealth solutions among patients with cardiovascular diseases.

Methods
We conducted a cross-sectional study based on an investigator-designed, validated questionnaire that included 19 items (demographics, health status, medical history, previous health care experience, expected telehealth functionalities, and preferred remote communication methods). Multivariate logistic regression was applied to assess the relationship between readiness and their determinants.

Results
Of the 249 respondents, 83.9% (n=209) consented to the use of telemedicine to contact a cardiologist. The nonacceptance of using telemedicine was 2 times more frequent in rural dwellers (odds ratio [OR] 2.411, 95% CI 1.003-5.796) and patients without access to the internet (OR 2.432, 95% CI 1.022-5.786). In comparison to participants living in rural areas, city dwellers demonstrated a higher willingness to use telemedicine, including following solutions: issuing e-prescriptions (19/31, 61.3% vs 141/177, 79.7%; P=.02); alarming at the deterioration of health (18/31, 58.1% vs 135/177, 76.3%; P=.03); and arranging or canceling medical visits (16/31, 51.6% vs 126/176, 71.6%; P=.03). Contact by mobile phone was preferred by younger patients (OR 2.256, 95% CI 1.058-4.814), whereas older patients and individuals who had no previous difficulties in accessing physicians preferred landline phone communication.

Conclusions
During a nonpandemic state, 83.9% of patients with cardiovascular diseases declared readiness to use telemedicine solutions.
Clinical Outcomes After a Digital Musculoskeletal Program for Acute and Subacute Pain: Observational, Longitudinal Study With Comparison Group
Authors: Wang Grace , Yang Manshu , Hong Mindy , Krauss Jeffrey , Bailey Jeannie F 
Published: June 2022

Background
Telerehabilitation for musculoskeletal (MSK) conditions may produce similar or better outcomes than usual care, but most telerehabilitation studies address only chronic or postsurgical pain.

Objective
We aimed to examine pain and function at 3, 6, and 12 weeks for individuals with acute and subacute MSK pain who took part in a digital MSK program versus a nonparticipant comparison group.

Methods
We conducted an observational, longitudinal study with a nonparticipant comparison group. The intervention group had video visits with physical therapists who recommended exercise therapies and educational articles delivered via an app. Nonparticipants were those who were registered but unable to participate because their benefit coverage had not yet begun. We collected pain and function outcomes through surveys delivered at 3-, 6-, and 12-week follow-ups. We conducted descriptive analyses, unadjusted regression, and mixed effects regression adjusting for baseline characteristics, time as fixed effects, and a time*group interaction term.

Results
The analysis included data from 675 nonparticipants and 262 intervention group participants. Compared to baseline, the intervention group showed significantly more pain improvement at 3, 6, and 12 weeks versus nonparticipants after adjusting for baseline factors. Specifically, the intervention group’s pain scores decreased by 55.8% at 3 weeks versus baseline, 69.1% at 6 weeks, and 73% at 12 weeks. The intervention group’s adjusted pain scores decreased from 43.7 (95% CI 41.1-46.2) at baseline to 19.3 (95% CI 16.8-21.8) at 3 weeks to 13.5 (95% CI 10.8-16.2) at 6 weeks to 11.8 (95% CI 9-14.6) at 12 weeks. In contrast, nonparticipants’ pain scores decreased by 30.8% at 3 weeks versus baseline, 45.8% at 6 weeks, and 46.7% at 12 weeks. Nonparticipants’ adjusted pain scores decreased from 43.8 (95% CI 42-45.5) at baseline to 30.3 (95% CI 27.1-33.5) at 3 weeks to 23.7 (95% CI 20-27.5) at 6 weeks to 23.3 (95% CI 19.6-27) at 12 weeks. After adjustments, the percentage of participants reporting that pain was better or much better at follow-up was significantly higher by 40.6% at 3 weeks, 31.4% at 6 weeks, and 31.2% at 12 weeks for intervention group participants versus nonparticipants. After adjustments, the percentage of participants with meaningful functional improvement at follow-up was significantly higher by 15.2% at 3 weeks and 24.6% at 12 weeks for intervention group participants versus nonparticipants.

Conclusions
A digital MSK program may help to improve pain and function in the short term among those with acute and subacute MSK pain.
Opicapone as an add-on to levodopa for reducing end-of-dose motor fluctuations in Parkinson’s disease: a systematic review and meta-analysis
Authors: Żegleń Magdalena , Śladowska Katarzyna , Kawalec Paweł , Brzostek Tomasz 
Published: June 2022

Aim:
To assess the clinical efficacy and safety profile of opicapone (25 and 50 mg once daily) versus placebo.
Patients:
Levodopa-treated adults with Parkinson’s disease.
Material & methods:
A systematic review and meta-analysis were conducted.
Results:
Opicapone provided a greater reduction in the absolute OFF-time, increased the chances of ≥1-h reduction in the OFF-time and ≥1-h increase in the ON-time compared with placebo. Receiving opicapone more often facilitated levodopa dose reduction versus placebo. There were no differences in the occurrence of adverse events (severe and leading to drug discontinuation), but receiving opicapone increased the frequency of dyskinesia.
Conclusion:
Opicapone demonstrated superior clinical efficacy to placebo, with a comparable general safety profile.
PENERAPAN KONSELING KELOMPOK DENGAN TEKNIK SELF MANAGEMENT DALAM RANGKA PENGELOLAAN STRES AKADEMIK PESERTA DIDIK KELAS VIII SMP
Authors: Vania Nella Rizqi , Supriatna Ecep , Fatimah Siti 
Published: June 2022

Tujuan dari penelitian ini yaitu untuk mengetahui apakah penerapan teknik self management dapat mengelola stres akademik peserta didik. Metode yang digunakan untuk penelitian ini yaitu Pendekatan kuantitatif, dengan Metode penelitian ini merupakan jenis quasi eksperimen dengan menggunakan model one control grup design, yaitu eksperimen atau pemberian treatment yang dilakukan pada kelompok kontrol dan kelompok eksperimen. Penelitan ini menyimpulkan bahwa hasil penelitian “penerapan konseling kelompok dengan teknik self management efektif dalam rangka mengelola stres akademik peserta didik kelas VIII D di SMPN 2 Batujajar, Kab.Bandung Barat ”, dapat disimpulkan bahwa stres akademik dapat direduksi melalui layanan konseling kelompok dengan self management. Berdasarkan hasil output diatas diketahui nilai sig.(2-tailed) adalah sebesar 0,000 < 0,05, maka HO ditolak dan Ha diterima. Dengan hasil perhitungan rata-rata skor stres akademik sebelum diberikan perlakuan adalah 131 dan setelah diberikan perlakuan teknik self management untuk mereduksi stres akademik pada peserta didik cenderung menurun dengan presentase 55%. Sehingga dapat disimpulkan bahwa ada perbedaan rata-rata antara hasil pretest dengan posttest yang artinya ada pengaruh dalam penerapan teknik self management dapat mereduksi stres akademik pada peserta didik kelas VIII D di SMPN 2 Batujajar di Kab. Bandung Barat.Kata Kunci : Stres akademik, Self management, konseling kelompok
LAYANAN BIMBINGAN KELOMPOK PADA SISWA MI MUSLIMIN YANG MEMILIKI KEPERCAYAAN DIRI RENDAH
Authors: Puri Pipih Ratna , Samsudin Asep , Siddik Riesa Rismawati 
Published: June 2022

The purpose of this study is to determine group guidance services in increasing student self-confidence. This research method uses literature review method from previous research. The subjects of this study are some of the results of previous research which are in accordance with the variables discussed in this research. From the results of research group guidance services can be used as an effort to increase student self-confidence, this is evidenced by a change in the subject after the implementation of group guidance (previous literature review). Based on the results of the study that had been done, it was found that through the group guidance technique the students' self-confidence began to build. This can be seen from the increased students' understanding of the rules in life and increased confidence in themselves regarding the ways that can be done in solving each problem. The conclusion of this study is that group guidance services can be used to increase students' self-confid Keywords: group guidance, self-confidence