bluuebunny/crossref_metadata_2025_split huggingface dataset:
Rat prostate tumors induce DNA synthesis in remote organs
Authors: Halin Bergström Sofia , Lundholm Marie , Nordstrand Annika , Bergh Anders 
Published: May 2022

AbstractAdvanced cancers induce systemic responses. However, if such systemic changes occur already when aggressive tumors are small, have not been thoroughly characterized. Here, we examined how localized prostate cancers of different sizes and metastatic potential affected DNA synthesis in the rest of the prostate and in various remote organs. Non-metastatic Dunning R-3327 G (G) tumor cells, metastatic MatLyLu (MLL) tumor cells, or vehicle were injected into the prostate of immunocompetent rats. All animals received daily injections of Bromodeoxyuridine (BrdU), to label cells/daughter cells with active DNA synthesis. Equal sized G- and MLL-tumors, similarly increased BrdU-labeling in the prostate, lymph nodes and liver compared to tumor-free controls. Prior to metastasis, MLL-tumors also increased BrdU-labeling in bone marrow and lungs compared to animals with G-tumors or controls. In animals with MLL-tumors, BrdU-labeling in prostate, lungs, brown adipose tissue and skeletal muscles increased in a tumor-size-dependent way. Furthermore, MLL-tumors induced increased signs of DNA damage (γH2AX staining) and accumulation of CD68 + macrophages in the lungs. In conclusion, small localized prostate cancers increased DNA synthesis in several remote tissues in a tumor type- and size-dependent way. This may suggest the possibility for early diagnosis of aggressive prostate cancer by examining tumor-induced effects in other tissues.
The transcription factor PREP1(PKNOX1) regulates nuclear stiffness, the expression of LINC complex proteins and mechanotransduction
Authors: Purushothaman Divya , Bianchi Laura F. , Penkov Dmitry , Poli Alessandro , Li Qingsen , Vermezovic Jelena , Pramotton Francesca M. , Choudhary Ramveer , Pennacchio Fabrizio A. , Sommariva Elena , Foiani Marco , Gauthier Nils , Maiuri Paolo , Blasi Francesco 
Published: May 2022

AbstractMechanosignaling, initiated by extracellular forces and propagated through the intracellular cytoskeletal network, triggers signaling cascades employed in processes as embryogenesis, tissue maintenance and disease development. While signal transduction by transcription factors occurs downstream of cellular mechanosensing, little is known about the cell intrinsic mechanisms that can regulate mechanosignaling. Here we show that transcription factor PREP1 (PKNOX1) regulates the stiffness of the nucleus, the expression of LINC complex proteins and mechanotransduction of YAP-TAZ. PREP1 depletion upsets the nuclear membrane protein stoichiometry and renders nuclei soft. Intriguingly, these cells display fortified actomyosin network with bigger focal adhesion complexes resulting in greater traction forces at the substratum. Despite the high traction, YAP-TAZ translocation is impaired indicating disrupted mechanotransduction. Our data demonstrate mechanosignaling upstream of YAP-TAZ and suggest the existence of a transcriptional mechanism actively regulating nuclear membrane homeostasis and signal transduction through the active engagement/disengagement of the cell from the extracellular matrix.
Differenzialdiagnose der Erythrozytose – Ursachen und klinische Bedeutung
Authors: Wille Kai , Sadjadian Parvis , Griesshammer Martin 
Published: May 2022

ZusammenfassungAufgrund ihres seltenen Auftretens stellt die Erythrozytose häufig eine Herausforderung für die behandelnden Ärzte dar. Die Erythropoese (= Produktion von Erythrozyten) ist im Knochenmark
angesiedelt, und das Hormon Erythropoetin (EPO) übernimmt die Kontrolle über ihre Regulation. Daher ist die Messung von EPO im Serum einer der wichtigsten diagnostischen Schritte. Bei der
Erythrozytose muss zwischen angeborenen und erworbenen Ursachen unterschieden werden. Darüber hinaus gibt es primäre und sekundäre Formen. Angeborene Ursachen von Erythrozytosen treten sehr
selten auf, werden meist in jungen Jahren diagnostiziert und sollten in spezialisierten Zentren behandelt werden. Die Polycythaemia vera (PV), eine klonale Störung und eine der wichtigsten
myeloproliferativen Neoplasien (neben der essenziellen Thrombozythämie und der primären Myelofibrose), stellt die häufigste primär erworbene Ursache für Erythrozytosen dar. Klinisch treten
eine erhöhte Thrombophilie und mikrovaskuläre Störungen auf. Die Initialtherapie bei Patienten mit PV umfasst die Verabreichung von Aspirin und Aderlass-Therapie. Sekundär erworbene Formen
der Erythrozytose treten vor allem aufgrund einer durch Nikotinabusus oder chronische Herz- und Lungenerkrankungen ausgelösten Hypoxie auf. Als weitere Differenzialdiagnosen müssen eine
tumorbedingte EPO-Produktion, Nierenerkrankungen oder eine exogene Zufuhr von EPO (= EPO-Doping) in Betracht gezogen werden.
Social Protection and Social Cohesion in Times of the COVID-19 Pandemic: Evidence from Kenya
Authors: Strupat Christoph 
Published: May 2022

AbstractThis paper examines empirically whether social protection in the form of social assistance programmes are affecting social cohesion during the COVID-19 pandemic. Using unique primary data from nationally representative, in-person surveys from Kenya allows for the exploration of the effect of social protection on attributes of social cohesion. The analysis employs a difference-in-differences approach that compares households with and without social assistance coverage before and after the first wave of the pandemic. The main findings show that social assistance does not influence attributes of social cohesion. One potential explanation of this result is that social assistance benefits were in general too small to entirely offset the negative economic consequences of the pandemic. Overall, these results point to the limitations of social assistance programmes that do not necessarily affect social cohesion in times of large covariate shocks, such as the COVID-19 pandemic.
Revenue recognition and channel stuffing in the Taiwanese semiconductor industry
Authors: Kuo Chii-Shyan , Yu Jia-Jye , Chang Feng-Chen 
Published: May 2022

AbstractThis paper examines whether a new revenue recognition standard, namely International Financial Reporting Standard 15 Revenue from Contracts with Customers (IFRS 15), incentivizes Taiwanese semiconductor companies to employ channel stuffing (CS) to meet or beat their earnings targets. By using a sample comprising 1399 firms listed on the Taiwanese Stock Exchange and over-the-counter markets between 2013 and 2019, we find that compared with Taiwanese firms in other sectors, semiconductor companies in Taiwan are more likely to employ CS to meet their earnings targets. Moreover, Taiwanese semiconductor companies have become more likely to use CS to meet their earnings targets since the implementation of IFRS 15. The obtained results pass a series of robustness checks and may help the potential driving forces for CS to be understood.
Realization of parallel experiments in a diamond anvil cell and their application to water–mineral interactions at high-pressure and high-temperature conditions
Authors: Jiang Runze , Lan Chunyuan , Du Jinxue , Tao Renbiao 
Published: May 2022

Parallel experiments are normally used to compare different chemical systems and conditions simultaneously. In the field of high-pressure experimental science, parallel experiments are hard to realize due to very limited reaction chamber size for the generation of high-pressure conditions, especially in diamond anvil cells (DACs). Multiple holes, instead of a single hole, can be drilled into a gasket (i.e., multihole gasket technique) to realize parallel experiments in a DAC. In this study, we conducted a series of systematic calibration experiments on multihole gasket techniques using statistical methods. Multiple (two or three or four) holes 100 µm in diameter were symmetrically drilled into a gasket by a laser drilling instrument with the help of a coded Python program. The pressure deviations among different holes in a gasket at average pressures below 10 GPa are constrained to less than 0.2 GPa in all calibration experiments at room temperature. We further checked the influences of the gasket material, hole number, pre-indented gasket thickness, and temperature on the pressure deviations among different holes in a gasket. Finally, we applied the multihole gasket technique in a DAC experiment and compared the solubility of calcite in different chemical environments at the same pressure and temperature conditions. The experimental results showed that the multihole gasket technique could be widely applied to study water–mineral interactions at high-P (&lt;10 GPa) and high-T (&lt;700 °C) conditions because multiple parallel experiments can be efficiently realized simultaneously.
Nitrogen fertilisation affected zinc and selenium biofortification in silage maize
Authors: Petković Klara , Manojlović Maja , Čabilovski Ranko , Lončarić Zdenko , Krstić Đorđe , Kovačević Dragan , Ilić Marko 
Published: May 2022

Context Biofortification of forage crops has become even more important, due to the improvement in livestock nutrition, but it has also had an indirect positive impact on the human diet. Aim This study investigated the effect of nitrogen and microelement (Zn and Se) fertilisation on yield and on the microelement composition of maize (Zea mays L.) silage. Methods Two field experiments were conducted using a two-factorial split-plot design with nitrogen fertilisation in three doses: 0, 120, 180 and 240 kg N/ha. The first experiment included foliar Zn fertilisation as the second factor (0, 1.5 kg Zn/ha and 1.5 kg Zn/ha + urea solution). The second experiment studied the effect of Se (10 g Se/ha). Key results Nitrogen fertilisation increased biomass yield, Cu and Mn concentration in silage maize. Application of Se and Zn did not affect the biomass yield, but it had a positive effect on Se and Zn concentration in plants. Zn and urea application in combination proved to be more efficient in increasing Zn concentration in plants when compared to Zn applied alone. Conclusions Nitrogen and fertilisation with Zn and Se can be a good tool in fodder plant biofortification because their application led to a yield increase (Zn), but at the same time to an improvement in the mineral composition of maize biomass, with essential elements (Zn and Se). Implications Although biofortification with 1.5 kg Zn/ha has achieved the concentration in maize biomass that can meet the nutritional needs of dairy cows, further research is needed to examine the adjuvant doses and forms of Zn to obtain high yields and Zn concentration in forage crops.
Maladaptation after a virus host switch leads to increased activation of the pro-inflammatory NF-κB pathway
Authors: Yu Huibin , Peng Chen , Zhang Chi , Stoian Ana M. M. , Tazi Loubna , Brennan Greg , Rothenburg Stefan 
Published: May 2022

Significance
Myxoma virus (MYXV) is benign in the natural brush rabbit host but causes a fatal disease in European rabbits. Here, we demonstrate that MYXV M156 inhibited brush rabbit protein kinase R (bPKR) more efficiently than European rabbit PKR (ePKR). Because ePKR was not completely inhibited by M156, there was a depletion of short–half-life proteins like the nuclear factor kappa B (NF-κB) inhibitor IκBα, concomitant NF-κB activation and NF-κB target protein expression in ePKR-expressing cells. NF-κB pathway activation was blocked by either hypoactive or hyperactive M156 mutants. This demonstrates that maladaptation of viral immune antagonists can result in substantially different immune responses in aberrant hosts. These different host responses may contribute to altered viral dissemination and may influence viral pathogenesis.
Fast slow folding of an outer membrane porin
Authors: Weatherill Eve E. , Fahie Monifa A. , Marshall David P. , Andvig Rachel A. , Cheetham Matthew R. , Chen Min , Wallace Mark I. 
Published: May 2022

Significance
Outer membrane porins play a crucial role in processes as varied as energy production, photosynthesis, and nutrient transport. They act as the gatekeepers between a gram-negative bacterium and its environment. Understanding how these proteins fold and function is important in improving our understanding and control of these processes. Here we use single-molecule methods to help resolve the apparent differences between the fast folding expected on a molecular scale and the slow kinetics observed in ensemble measurements in the laboratory.
Quantum guessing games with posterior information
Authors: Carmeli Claudio , Heinosaari Teiko , Toigo Alessandro 
Published: May 2022

Abstract
Quantum guessing games form a versatile framework for studying different tasks of information processing. A quantum guessing game with posterior information uses quantum systems to encode messages and classical communication to give partial information after a quantum measurement has been performed. We present a general framework for quantum guessing games with posterior information and derive structure and reduction theorems that enable to analyze any such game. We formalize symmetry of guessing games and characterize the optimal measurements in cases where the symmetry is related to an irreducible representation. The application of guessing games to incompatibility detection is reviewed and clarified. All the presented main concepts and results are demonstrated with examples.
Interaction between electrostatic collisionless shocks generates strong magnetic fields
Authors: Boella E , Schoeffler K , Shukla N , Innocenti M E , Lapenta G , Fonseca R , Silva L O 
Published: May 2022

Abstract
The head-on collision between electrostatic shocks is studied via multi-dimensional particle-in-cell simulations. A strong magnetic field develops after the interaction, which causes the shock velocities to drop significantly. This transverse magnetic field is generated by the Weibel instability, which is driven by pressure anisotropies due to longitudinal electron heating while the shocks approach each other. The possibility to explore the physics underpinning the shock collision in the laboratory with current laser facilities is discussed.
Towards the surface flashover in DC GIL/GIS: the electric field distribution and the surface charge accumulation
Authors: Wu Shaocong , Xu Hao , Zhang Xuanning , Liang Yanyu , Shao Yuming , Wang Cong , Tu Youping , Xu Yongsheng 
Published: May 2022

Abstract
Under DC voltage, the interface charge of the spacer in gas-insulated metal-enclosed transmission lines (GIL) and gas-insulated metal-enclosed switchgear (GIS) is prone to accumulate, and the charge is an important factor to induce surface flashover. On different spacers, the distribution of the electric field can be varied and affect the flashover greatly. This paper concentrates on the surface flashover induced by solid-gas interface charge accumulation in DC GIL/GIS. The electric field distribution of the real insulator and the electrode structure commonly used in research are analyzed and summarized into two distribution forms: the tangential-component dominant type and the hybrid type. According to the electric field distribution forms, how the density distribution and electric field distortion of interface charge influence the flashover voltage of spacer is reviewed, and the influence of metal particles on charge and surface flashover is reviewed as well. Efforts to understand the mechanism of the surface flashover have alse been tracked.
Non-adiabatic evolution of dark sector in the presence of U(1)Lμ
– Lτ
gauge symmetry
Authors: Tapadar Ananya , Ganguly Sougata , Roy Sourov 
Published: May 2022

Abstract
In secluded dark sector scenario, the connection between
the visible and the dark sector can be established through
a portal coupling and its presence opens up the possibility
of non-adiabatic evolution of the dark sector.
To study the non-adiabatic evolution of the dark sector,
we have considered a U(1)
Lμ
– Lτ

⊗ U(1)
X

extension of the standard model (SM). Here
the dark sector is charged only under U(1)
X
gauge symmetry whereas
the SM fields are singlet under this symmetry. Due to the
presence of tree-level
kinetic mixing between U(1)
X
and U(1)
Lμ
– Lτ

gauge bosons, the dark sector evolves non-adiabatically
and thermal equilibrium between the visible and dark sector
is governed by the portal coupling.
Depending on the values of the portal coupling (ϵ),
dark sector gauge coupling (gX
),
mass of the dark matter (m
χ) and
mass of the dark vector boson (m
Z'), we study the temperature
evolution of the dark sector as well as the various non-equilibrium
stages of the dark sector in detail.
Furthermore we have also investigated the constraints
on the model parameters from various laboratory and astrophysical searches. We
have found that the parameter space for the non-adiabatic
evolution of dark sector is significantly constrained for
m
Z' ≲ 100 MeV from
the observations of beam dump experiments, stellar cooling etc.
The relic density satisfied region of our parameter space
is consistent with the bounds from direct detection, and
self interaction of dark matter (SIDM) for the mass ratio
r ≡ m
Z'/m
χ = 10-3 and these bounds will be more relaxed
for larger values of r. However the constraints from
measurement of diffuse γ-ray background flux
and cosmic microwave background (CMB) anisotropy
are strongest for r = 10-1 and for smaller
values of r, they are not significant.
Scrutinizing entropic uncertainty and quantum discord in an open system under quantum critical environment
Authors: Pourkarimi Mohammad Reza , Haseli Soroush , Haddadi Saeed , Hadipour Maryam 
Published: May 2022

Abstract
We explore the dynamics of quantum discord (QD) and entropic uncertainty lower bound for a two-qubit system independently coupled to an Ising spin chain. For this model, we obtain the analytic results of QD and uncertainty bound and find that there is a trade-off between them. We also examine the effect of the number of spins and the coupling strength to a transverse field on these two quantum criteria.
The Relative Orientation between Local Magnetic Field and Galactic Plane in Low Latitude Dark Clouds
Authors: Choudhury Gulafsha B. , Das Himadri S. , Medhi B. J. , Pandey J. C. , Wolf S. , Dhar T. K. , Mazarbhuiya A. M. 
Published: May 2022

Abstract
In this work, we study the magnetic field morphology of selected star-forming clouds spread over the galactic latitude (b) range −10° to 10°. The polarimetric observations of clouds CB24, CB27 and CB188 are conducted to study the magnetic field geometry of those clouds using the 104 cm Sampurnanand Telescope (ST) located at ARIES, Manora Peak, Nainital, India. These observations are combined with those of 14 further low latitude clouds available in the literature. Most of these clouds are located within a distance range 140–500 pc except for CB3 (∼2500 pc), CB34 (∼1500 pc), CB39 (∼1500 pc) and CB60 (∼1500 pc). Analyzing the polarimetric data of 17 clouds, we find that the alignment between the envelope magnetic field (

θ

B

env

) and galactic plane (GP) (θ
GP) of the low-latitude clouds varies with their galactic longitudes (l). We observe a strong correlation between the longitude (l) and the offset (

θ

off

=
∣

θ

B

env

−

θ

GP

∣

) which shows that

θ

B

env

is parallel to the GP when the clouds are situated in the region 115° < l < 250°. However,

θ

B

env

has its own local deflection irrespective of the orientation of θ
GP when the clouds are at l < 100° and l > 250°. To check the consistency of our results, the stellar polarization data available in the Heiles catalog are overlaid on the DSS image of the clouds having mean polarization vector of field stars. The results are almost consistent with the Heiles data. A systematic discussion is presented in the paper. The effect of turbulence in the cloud is also studied which may play an important role in causing the misalignment phenomenon observed between

θ

B

env

and θ
GP. We have used Herschel (Herschel is an ESA space observatory with science instruments provided by European-led Principal Investigator consortia and with important participation from NASA.) SPIRE 500 μm and SCUBA 850 μm dust continuum emission maps in our work to understand the density structure of the clouds.
Kano-FBS model: a data-driven innovative design approach for smart product-service system development
Authors: Ying Yuhan , Xiang Zhongxia , Cong Jingchen , Zhu Liming 
Published: May 2022

Abstract
Smart product-service system (Smart PSS), as an emerging digital paradigm, should meet user expectations and optimize their experience with a higher degree of sustainability. As a complex solution bundle with digital technology, its innovative design method differs from the existing method for traditional products. For a reason that massive user-generated data can be collected in the usage stage, which can be utilized to obtain new user requirements and calculate the user satisfaction degree. According to the real-time user preference information, some modules can be upgraded or adjusted in order to extend the lifecycle of the sustainable Smart PSS. Nevertheless, few studies focus on conducting innovative design by concerning massive information collected in the usage stage in a sustainable Smart PSS environment, let alone a novel approach to support the information re-use in product development of other fields. Aiming to fill this gap, a new innovative design methodology is proposed by combining Function-Behavior-Structure (FBS) and Kano model to guide Smart PSS development. User requirements and behaviors are predicted and analysed by forecasting and collecting information from the perspective of information. As an illustrative case study, a self-service medicine vending system is described to explain the proposed approach. This research provides guidance for Smart PSS in the medical field.
Human-Simulation Logical Control Research on Lifting Electromagnet System
Authors: Yongbiao Chen , Yan Ding , Wei Lin 
Published: May 2022

Abstract
The variability and randomness of the load bring certain difficulties to the control accuracy of the electromagnet. A novel human-simulation logical control research on liftingelectromagnet is studied in this paper. Based on the pan-Boolean theory, the logical control model for electromagnetic force control system is based on control practice and is consisted by a series of control rules. The dynamic control model of electromagnetic force control system is established in Matlab/Simu1ink, the simulation experimental results show that if adding the human-simulation logical controller, the overshoot of the system is smaller, the response speed is faster, and the steady-state accuracy is higher. The controller can better meet the working requirements of the lifting electromagnet.