bluuebunny/crossref_metadata_2025_split huggingface dataset:
UPAYA MENINGKATKAN HASIL PEMBELAJARAN LOMPAT JAUH MELALUI PENDEKATAN BERMAIN LOMPAT KANGURU PADA SISWA KELAS V SD NEGERI 30 CAKRANEGARA
Authors: Syafrudin Muhammad 
Published: April 2022

Pelaksanaan pembelajaran lompat jauh pada siswa kelas V SDN 30 Cakranegara Kota Mataram kurang memuaskan bagi guru penjasorkes, hal yang didapatkan siswa pada tes evaluasi akhir pembelajaran masih banyak siswa yang nilainya belum memenuhi standar kriteria ketuntasan minimal (KKM) yang telah ditetapkan. Sedangkan tujuan diadakan penelitian ini adalah untuk mengefektifitaskan pembelajaran dengan cara pendekatan bermain lompat kanguru atau mengevaluasikan berbagai macam permainan kedalam pembelajaran. Berdasarkan permasalahan diatas maka peneliti menyimpulkan rumusan permasalahan yang dihadapi oleh penelitian yaitu “Apakah melalui oendekatan permainan lompat kanguru sebagai pembelajran dapat meningkatkan hasil belajar lompat jauh pada siswa kelas V SDN 30 Cakranegara tahun Pelajaran 2019/2020. Lompat jauh melalui pendekatan lompat kanguru “longu” merupakan salah satu alternative pembelajaran lompat jauh di Sekolah Dasar. Namun kenyataannya dalam proses pembelajaran belum terlaksana secara optimal, metode yang digunakan peneliti adalah penelitian Tindakan Kelas (PTK). Hasil peneltian yang menggunakan 2 siklus dan 4 pertemuan menunjukan di siklus I nilai rata-rata akhir kelas 71,9 dengan nilai persentase ketuntasan 76% nilainya masih kurang memuaskan. Maka dilanjutkan di siklus II nilai rata-rata akhir kelas 75,04 dengan nilai persentase 95,2% nilai yang dihasilkan sesuai dengan yang diinginkan. Pengumpulan data dilakukan dengan menggunakan data pengamatan dilapangan dan kuesioner yang diperoleh dari evaluasi. Berdasarkan penelitian dapat disimpulkan bahwa melalui pendekatan bermain lompat kanguru pada materi lompat jauh dengan menggunakan media botol aqua dan pralon sebagai sarana dan prasarana pembelajaran mengalami peningkatan dalam hasil belajar siswa kelas V SDN 30 Cakranegara tahun pelajaran 2019/2020 Kota Mataram. Saran dari peneliti meliputi beberapa hal yaitu: diharapkan bagi guru penjasorkes di Sekolah Dasar untuk menggunakan Penelitian Tindakan Kelas (PTK) dalam pembelajaran, guru dapat memvariasikan berbagai macam bentuk permainan dalam pembelajaran, dan media botol aqua pralon dan dapat digunakan untuk mengatasi kekurangan alat peraga dalam pembelajaran lompat jauh.Kata Kunci ; Lompat Jauh, Permainan Lompat Kanguru, Pembelajaran.
Perilaku Merokok pada Wanita pada Masa Pandemi Covid-19: Study Kasus di Kota Bandar Lampung
Authors: Pratama Randy Yusuf 
Published: April 2022

Rokok merupakan faktor risiko penyakit yang memberikan kontribusi paling besar di banding faktor risiko lainnya (komplikasi kehamilan, gangguan kesuburan, gangguan menstruasi). Perokok aktif perempuan sebenarnya faham resiko dari perilaku merokoknya tersebut. Merokok bagi seorang perempuan yaitu merokok dapat mengurangi sekresi estrogen yang diduga bertanggung jawab atas gangguan menstruasi termasuk timbulnya rasa nyeri. Tujuan penelitian ini adalah diketahui informasi lebih dalam perilaku merokok di masa pandemi covid 19 pada wanita di Kota Bandar Lampung tahun 2020. Penelitian ini merupakan penelitian kualitatif dengan pendekatan study kasus informan dalam penelitian ini adalah wanita perokok sebanyak 5 informan. Teknik pengumpulan data melalui wawancara mendalam, teknik analisis data dilakukan dengan trianggulasi sumber. Hasil penelitian Perceived Susceptibility, perilaku merokok pada wanita dipengaruhi oleh keluarga dan lingkungan pergaulan. Perceived Severity, informan mengabaikan bahaya yang dirasakan terhadap pesan atau informasi yang telah beredar di lingkungan. Perceived Benefit, sudah menjadi kebiasaan seperti laki-laki, merasa lebih santai dan nikmat jika merokok pada saat ada masalah atau stres. Perceived Barrier, tidak pernah dihiraukan bahayanya oleh informan karena sudah menjadi kebisaan atau budaya merokok dilingkungan sekitar, Cues to Action Informan belum menemukan cara untuk berhenti merokok, dengan adanya covid 19 kebiasaan merokok makin sulit untuk berhenti dengan alasan mereka jenuh tidak bisa bepergian. Saran pada penelitian ini hendaknya wanita yang merokok sebaiknya membentuk kesadaran dalam diri dengan cara memiliki niat dan kemauan diri (komitmen) yang kuat disertai dengan turut serta dalam program berhenti merokok agar dapat secara perlahan mengurangi kebiasaan merokoknya, karena merokok berbahaya bagi kesehatan apalagi bagi kaum perempuan
Kata Kunci: Perilaku Merokok Wanita, Covid—19, Perilaku Merokok
Analysis of Antenna Types on the Effect of GSM Module Signals as Remote Vehicle Safety
Authors: Martawati Mira Esculenta , Rohman Fatkhur , Fachrudin Arif R , Bhakt Muhammad Ibnan Utama 
Published: April 2022

The National Police revealed that in 2018 there were 165,918 cases of crime in Indonesia, with 19,380 cases of theft due to the lack of additional safety in vehicles. Thus, remote vehicle safety is needed to turn off the vehicle in the event of an act of theft. However, this remote security is still difficult to work if the signal quality from the BTS is weak. Because it needs a signal amplifier in the GSM module. The purpose of this paper is to analyze the effect of the GSM module signal on the injector response time as an android-based long-distance vehicle safety. The signal booster is useful so that this long-distance vehicle safety can work properly when the signal quality from the BTS is weak. The research method used is the two-way Anova method. There are two independent variables, namely: (1) BTS signal quality; (2) the antenna material is copper and aluminum. The dependent variable uses the injector response time. The test results show that in testing the BTS signal quality, copper antennas have the fastest response time compared to aluminum antennas. -60 dBm is 4.402 second and -113 dBm is 5.472 second. The conclusion of this study is that copper antennas respond faster than aluminum antennas, because copper has a higher conductivity than aluminum.
Keywords: Vechicle Safety, GSM Module, Remote Vehicle Safety
Pengaruh Pernikahan Sedarah Terhadap Keturunan (Studi Analisis Tafsir Sains Dalam Qs. An-Nisa’: 23)
Authors: Asmuni Asmuni 
Published: April 2022

Penelitian ini bertujuan untuk mengetahui mengapa dalam al-Qur‟an sampai mengharamkan pernikahan itu. Kemudian peneliti mengaitkan dengan ilmu sains tentang genetika (keturunan), bagaimana keturunan yang dihasilkan dari pernikahan tersebut. Sehingga penulis mengambil judul “Pengaruh Pernikahan Sedarah Terhadap Keturunan (Studi Analisis Tafsir Sains Dalam QS. An-Nisa’: 23). Adapun jenis penelitian ini adalah penelitian kualitatif dengan pendekatan tafsir „ilmiy. Yaitu memahami al-Qur‟an melalui pendekatan sainsmodern. Sumber data diperoleh dari sumber data primer dan sumber data sekunder. Data penelitian yang terkumpul kemudian dianalisis dengan pendekatan ilmu sains. Dari penelitian yang dilakukan diperoleh hasil bahwa dalam pernikahan diharapkan bisa memperluas hubungan kekeluargaan, jadi tidak ada urgensinya apabila menikahi kerabat dekat sendiri. Dalam hubungan antara suami istri pastilah terjadi perselisihan di antara keduanya. Dengan demikian menikahi mereka akan menyebabkan pemutusan kerabat, sehingga dapat menjadikan kekerasan hati diantara mereka. Maka, hal-hal yang menyebabkan keharaman juga dihukumi haram. Perkawinan yang dilakukan antar keluarga cenderung menghasilkan keturunan yang abnormal. Bahkan, hampir selalu terjadi peningkatan kematian atau penyakit pada keturunan hasil perkawinan antar keluarga. Seseorang yang mempunyai hubungan darah akan lebih mungkin memberikan gen yang sama dibandingkan dengan orang-orang yang tidak mempunyai hubungan darah. Inbreeding (perkawinan keluarga) akan mengubah frekuensi gen resesif dalam populasi, sehingga secara relatif lebih banyak dilahirkan individu-individu homozigot abnormal
Kata Kunci: Pernikahan sedarah, Keturunan, Tafsir Sains, Hukum Islam
Tremor in Writer’s Cramp Patients: A Retrospective Study
Authors: Datta Abhigyan , Batra Nitya , Pandey Sanjay 
Published: April 2022

Background: Tremor is one of the important motor phenotypes of dystonia, however, there is a lacuna in the literature regarding the occurrence of tremor in task-specific dystonia such as writer’s cramp (WC).Aims: To delineate the demographic and clinical characteristics of tremor in WC patients.Methods: This is a detailed chart review of 105 patients of WC who were classified as WC with dystonic action tremor (WCT+) (n = 39; 37.1%) and WC without tremor (WCT-) (n = 66; 53.9%).Results: The mean age of patients was 41.10 ± 14.02 years in the WCT + group and 36.40 ± 14.66 years in the WCT-group. Males were more commonly affected (94.9% in WCT+ and 84.8% in WCT-). The mean duration of disease was significantly higher in WCT + as compared to WCT- (4.16 ± 4.48 years vs. 2.57 ± 2.81 years, p = 0.024). One-third of our patients (29.52%; n = 31) were students but, and the majority of them were classified as WCT- (80.64%, n = 25, p = 0.01). However, tremor was present in all the three doctors in our cohort with WC (p = 0.03). The motor overflow to the elbow and shoulder was significantly associated with the presence of tremor (46.1% of WCT + vs. 15.2% of WCT-patients, p = 0.001). Statistically, there were no significant differences between WCT+ and WCT-patients regarding the presence of complex WC (dystonia during other activities as well) (p = 0.976), mirror dystonia (p = 0.211), and finger flexion/extension abnormalities (p = 0.111).Conclusion: The presence of tremor in WC was associated with a longer duration of disease and the presence of motor overflow.
Pharmacokinetics, Mass Balance, Excretion, and Tissue Distribution of Plasmalogen Precursor PPI-1011
Authors: Smith Tara , Knudsen Kaeli J. , Ritchie Shawn A. 
Published: April 2022

PPI-1011 is a synthetic plasmalogen precursor in development as a treatment for multiple plasmalogen-deficiency disorders. Previous work has demonstrated the ability of PPI-1011 to augment plasmalogens and its effects in vitro and in vivo, however, the precise uptake and distribution across tissues in vivo has not been investigated. The purpose of this study was to evaluate the pharmacokinetics, mass balance, and excretion of [14C]PPI-1011 following a single oral administration at 100 mg/kg in Sprague-Dawley rats. Further tissue distribution was examined using quantitative whole-body autoradiography after both single and repeat daily doses at 100 mg/kg/day. Non-compartmental analysis showed that following a single dose, PPI-1011 exhibited peak levels between 6 and 12 h but also a long half-life with mean t1/2 of 40 h. Mass balance showed that over 50% of the compound-associated radioactivity was absorbed by the body, while approximately 40% was excreted in the feces, 2.5% in the urine, and 10% in expired air within the first 24 h. Quantitative whole-body autoradiography following a single dose showed uptake to nearly all tissues, with the greatest initial uptake in the intestines, liver, and adipose tissue, which decreased time-dependently throughout 168 h post-dose. Following 15 consecutive daily doses, uptake was significantly higher across the entire body at 24 h compared to single dose and remained high out to 96 h where 75% of the initially-absorbed compound-associated radioactivity was still present. The adipose tissue remained particularly high, suggesting a possible reserve of either plasmalogens or alkyl diacylglycerols that the body can pull from for plasmalogen biosynthesis. Uptake to the brain was also definitively confirmed, proving PPI-1011’s ability to cross the blood-brain barrier. In conclusion, our results suggest that oral administration of PPI-1011 results in high uptake across the body, and that repeated dosing over time represents a viable therapeutic strategy for treating plasmalogen deficiencies.
A Partially Randomized Patient Preference Trial to Assess the Quality of Life and Patency Rate After Minimally Invasive Cardiac Surgery-Coronary Artery Bypass Grafting: Design and Rationale of the MICS-CABG PRPP Trial
Authors: Gong Yichen , Wang Xiaoxiao , Li Nan , Fu Yuanhao , Zheng Hui , Zheng Ye , Zhan Siyan , Ling Yunpeng 
Published: April 2022

BackgroundMinimally invasive cardiac surgery-coronary artery bypass grafting (MICS-CABG) has emerged as a safe alternative to standard cardiac surgery. However, treatment preferences can decrease the generalizability of RCT results to the clinical population (i.e., reduce external validity) and influence adherence to the treatment protocol and study outcomes (i.e., reduce internal validity). However, this has not yet been properly investigated in randomized trials with consideration of treatment preferences.Study DesignIn this study, patients with a preference will be allocated to treatment strategies accordingly, whereas only those patients without a distinct preference will be randomized. The randomized trial is a 248-patient controlled, randomized, investigator-blinded trial. It is designed to compare whether treatment with MICS-CABG is beneficial in comparison to CABG. This study is aimed to establish the superiority hypothesis for the physical component summary (PCS) accompanied by the non-inferiority hypothesis for overall graft patency. Patients with no treatment preference will be randomized in a 1:1 fashion to one of the two treatment arms. The primary efficacy endpoints are the PCS score at 30 days after surgery and the overall patency rate of the grafts within 14 days after surgery. Secondary outcome measures include the PCS score and patency rate at different time points. Safety endpoints include major adverse cardiac and cerebrovascular events, complications, bleeding, wound infection, death, etc.ConclusionsThis trial will address essential questions of the efficacy and safety of MICS-CABG. The study will also address the impact of patients' preferences on external validity and internal validity.
NEU1 Regulates Mitochondrial Energy Metabolism and Oxidative Stress Post-myocardial Infarction in Mice via the SIRT1/PGC-1 Alpha Axis
Authors: Guo Zhen , Fan Di , Liu Fang-Yuan , Ma Shu-Qing , An Peng , Yang Dan , Wang Min-Yu , Yang Zheng , Tang Qi-Zhu 
Published: April 2022

ObjectiveNeuraminidase 1 (NEU1) participates in the response to multiple receptor signals and regulates various cellular metabolic behaviors. Importantly, it is closely related to the occurrence and progression of cardiovascular diseases. Because ischemic heart disease is often accompanied by impaired mitochondrial energy metabolism and oxidative stress. The purpose of this study was to investigate the functions and possible mechanisms of NEU1 in myocardial remodeling and mitochondrial metabolism induced by myocardial infarction (MI).MethodsIn this study, the MI-induced mouse mode, hypoxia-treated H9C2 cells model, and hypoxia-treated neonatal rat cardiomyocytes (NRCMs) model were constructed. Echocardiography and histological analysis were adopted to evaluate the morphology and function of the heart at the whole heart level. Western blot was adopted to determine the related expression level of signaling pathway proteins and mitochondria. Mitochondrial energy metabolism and oxidative stress were detected by various testing kits.ResultsNeuraminidase 1 was markedly upregulated in MI cardiac tissue. Cardiomyocyte-specific NEU1 deficiency restored cardiac function, cardiac hypertrophy, and myocardial interstitial fibrosis. What is more, cardiomyocyte-specific NEU1 deficiency inhibited mitochondrial dysfunction and oxidative stress induced by MI. Further experiments found that the sirtuin-1/peroxisome proliferator-activated receptor γ coactivator α (SIRT1/PGC-1α) protein level in MI myocardium was down-regulated, which was closely related to the above-mentioned mitochondrial changes. Cardiomyocyte-specific NEU1 deficiency increased the expression of SIRT1, PGC-1α, and mitochondrial transcription factor A (TFAM); which improved mitochondrial metabolism and oxidative stress. Inhibition of SIRT1 activity or PGC-1α activity eliminated the beneficial effects of cardiomyocyte-specific NEU1 deficiency. PGC-1α knockout mice experiments verified that NEU1 inhibition restored cardiac function induced by MI through SIRT1/PGC-1α signaling pathway.ConclusionCardiomyocyte-specific NEU1 deficiency can alleviate MI-induced myocardial remodeling, oxidative stress, and mitochondrial energy metabolism disorder. In terms of mechanism, the specific deletion of NEU1 may play a role by enhancing the SIRT1/PGC-1α signaling pathway. Therefore, cardiomyocyte-specific NEU1 may provide an alternative treatment strategy for heart failure post-MI.
Relationships of Serum Bone Turnover Markers With Metabolic Syndrome Components and Carotid Atherosclerosis in Patients With Type 2 Diabetes Mellitus
Authors: Li Wei , Liu Xiaojun , Liu Lijun , Zhang Lei , Li Mengdi , Liu Rui , Li Tianfang , Chen En , Liu Shengyun 
Published: April 2022

ObjectiveThis study aimed to investigate the association of serum bone turnover markers (BTMs) with metabolic syndrome components and carotid atherosclerosis in patients with type 2 diabetes mellitus (T2DM).MethodsWe performed a cross-sectional based study in T2DM populations. Serum BTMs including N-terminal osteocalcin (N-MID), β-cross-linked C-telopeptide of type I collagen (β-CTX), and procollagen type I N-terminal propeptide (PINP) were measured by immunoassay method. Carotid artery intima-media thickness and carotid artery plaque (CAP) were measured by B-mode ultrasound.ResultsThe serum N-MID, PINP, and β-CTX levels significantly lower in the CAP group compared with the non-CAP group. N-MID and PINP levels were inversely associated with fasting blood glucose, HOMA-IR, CRP, eGFR, and triglycerides (all P &lt; 0.05), whereas β-CTX levels were negatively associated with triglycerides (P &lt; 0.05). After multiple adjustment, the odds ratios (ORs) were substantially higher for CAP with decreased N-MID level (OR = 0.958; 95% CI = 0.926–0.991; P = 0.013). However, serum levels of PINP and β-CTX were not associated with the presence of CAP. Multivariate logistic regression analysis further revealed that serum N-MID, PINP, and β-CTX levels were significantly associated with hypertriglyceridemia, whereas serum N-MID and β-CTX levels were associated with overweight/obesity risk.ConclusionsThese findings indicated that serum N-MID level was an independent risk factor for carotid atherosclerosis, whereas BTM levels were associated with other metabolic syndrome components in a T2DM population.
Importance of Echocardiography and Clinical “Red Flags” in Guiding Genetic Screening for Fabry Disease
Authors: Citro Rodolfo , Prota Costantina , Ferraioli Donatella , Iuliano Giuseppe , Bellino Michele , Radano Ilaria , Silverio Angelo , Migliarino Serena , Polito Maria Vincenza , Ruggiero Artemisia , Napoletano Rosa , Bellizzi Vincenzo , Ciccarelli Michele , Galasso Gennaro , Vecchione Carmine 
Published: April 2022

IntroductionAim of this study was to evaluate, in a metropolitan area not already explored, the prevalence of Anderson–Fabry disease, by genetic screening, in patients with echocardiographic evidence of left ventricular hypertrophy (LVH) of unknown origin and “clinical red flags”.MethodsFrom August 2016 to October 2017, all consecutive patients referring to our echo-lab for daily hospital practices with echocardiographic evidence of LVH of unknown origin in association with history of at least one of the classical signs and symptoms related to Fabry disease (FD) (neuropathic pain, anhidrosis/hypohidrosis, angiokeratomas, gastrointestinal problems, chronic kidney disease, or cerebrovascular complications) were considered eligible for the FD genetic screening program. Through dried blood spot testing, α-Galactosidase A (α-Gal A) activity and analysis of the GLA gene were performed.ResultsAmong 3,360 patients who underwent transthoracic echocardiography in our echo-lab during the study period, 30 patients (0.89%; 19 men, mean age 58 ± 18.2 years) were selected. FD was diagnosed in 3 (10%) unrelated patients. Three different GLA gene mutations were detected, one of them [mutation c.388A &gt; G (p.Lys130Glu) in exon 3] never described before. Moreover, probands' familiar genetic screening allowed the identification of 5 other subjects affected by FD.ConclusionIn a metropolitan area not previously investigated, among patients with LVH of unknown origin associated with other “red flags,” undergoing genetic screening, the prevalence of FD was very high (10%). Our results highlight the importance of an echocardiographic- and clinical-oriented genetic screening for FD in patients with uncommon cause of LVH.
Preoperative Nomogram and Risk Calculator for Postoperative Hypoxemia and Related Clinical Outcomes Following Stanford Type A Acute Aortic Dissection Surgery
Authors: Sheng Weiyong , Le Sheng , Song Yu , Du Yifan , Wu Jia , Tang Chuanbin , Wang Hongfei , Chen Xing , Wang Su , Luo Jingjing , Li Rui , Xia Jiahong , Huang Xiaofan , Ye Ping , Wu Long , Du Xinling , Wang Dashuai 
Published: April 2022

BackgroundHypoxemia is a common complication after Stanford type A acute aortic dissection surgery (AADS), however, few studies about hypoxemia after AADS exist. The aims of this study were to identify independent risk factors for hypoxemia after AADS and to clarify its association with clinical outcomes.MethodsPatients undergoing AADS from 2016 to 2019 in our hospital were identified and used as a training set. Preoperative variables were first screened by univariate analysis and then entered into a multivariate logistic regression analysis to identify independent risk factors. A nomogram and an online risk calculator were constructed based on the logistic model to facilitate clinical practice and was externally validated in an independent dataset.ResultsSevere hypoxemia developed in 119 of the 492 included patients (24.2%) and poorer clinical outcomes were observed in these patients. Five independent risk factors for severe hypoxemia after AADS were identified by multivariate analysis, including older age, smoking history, renal insufficiency, higher body mass index, and white blood cell count. The model showed good calibration, discrimination, and clinical utility in the training set, and was well validated in the validation set. Risk stratification was performed and three risk groups were defined as low, medium, and high risk groups. Hypertension was identified as an independent risk factor for moderate hypoxemia besides the five predictors mentioned above, and renal insufficiency was not significant for mild hypoxemia by multivariate analysis. In addition, although frozen elephant trunk was associated with increased risk of postoperative hypoxemia in the univariate analysis, frozen elephant trunk was also not identified as an independent risk factor for postoperative hypoxemia in the multivariate analysis.ConclusionHypoxemia was frequent following AADS, related to poorer clinical outcomes. Predictors were identified and a nomogram as well as an online risk calculator predicting severe hypoxemia after AADS was developed and validated, which may be helpful for risk estimation and perioperative management.