bluuebunny/crossref_metadata_2025_split huggingface dataset:
Experimental measurement of thermal conductivity of stereolithography photopolymer resins
Authors: Oval-Trujillo A. , Rodríguez A. , Pérez-Artieda G. , Dung Y. , Alegría P. 
Published: July 2022

Abstract
The rise in the use of additive manufacturing highlights the importance of knowing the properties of the materials employed in this technology. Therefore, for the commercialization of thermal applications with this technology, heat management is essential. Here, computational modelling is often utilised to simulate heat transfer in various components, and knowing precisely the values of thermal conductivity is one of the key parameters. In this line of research, this paper includes the experimental study of three different types of resin used in additive manufacturing by stereolithography. Based on a test bench designed by researchers from the Public University of Navarre, which measures thermal contact resistances and thermal conductivities, the thermal conductivity analysis of three kinds of resin is carried out. This measuring machine employs the temperature difference between the faces and the heat flux that crosses the studied sample to determine the mentioned parameters. The thermal conductivity results are successful considering the constitution of the material studied and are consistent with the conductivity values for thermal insulating materials. The ELEGOO standard resin stands out among the others due to its low thermal conductivity of 0.366 W/m K.

Article Highlights

Calculating thermal conductivity of three resins used in additive manufacturing by stereolithography.

Contributing to a knowledge-based design of heat sink in thermal conductivity measurement bench.

Improvement of the thermal conductivity measurement bench by reducing the uncertainty for its application in low thermal conductivity materials testing.

Graphical abstract
Hospital effluents as sources of antibiotics residues, resistant bacteria and heavy metals in Benin
Authors: Deguenon Esther , Dougnon Victorien , Houssou Vincentia Marie Camille , Gbotche Elodie , Ahoyo Richard Adjovi , Fabiyi Kafayath , Agbankpe Jerrold , Mousse Wassiyath , Lougbegnon Christelle , Klotoe Jean Robert , Tchobo Fidele , Bankole Honoré , Boko Michel 
Published: July 2022

AbstractThis study aims to evaluate the bacteriological, chemical, and toxicological quality of hospital effluents in Benin. Eighteen (18) samples were collected from the south and north of Benin, and poles were set up. Bacteriological analysis was carried out according to the French National Organization for Standardization (AFNOR) standard. Identification of the bacterial species isolated was performed using the API 20E gallery and specific biochemical tests. Antibiotic residues were searched by following ELISA kit instructions. 109 bacterial isolates were obtained, with a predominance of non-enterobacteria (37.7%) and Acinetobacter spp. (24.6%), followed by Klebsiella spp. (11.48%); S. aureus and Coagulase-negative staphylococci (CoNS) were isolated at the same frequency (6.5%). Physico-chemical and toxicological parameter analyses showed that they were in conformity with the standards of discharge into the environment. The pH, temperature, electrical conductivity, total solids below, P-redox and suspended solids measured were, on average, 6.83, 27.21 °C, 693.68 µS/cm, 693.68 mg/l, 1.68 mV and 0.15 mg/l, respectively. For heavy metals, cadmium was most prevalent (0.22 mg/l), followed by nickel (0.18 mg/l) and lead (0.03 mg/l). The average antibiotic residue concentrations ranged from 0.043 to 7.65 µg/l. Ciprofloxacin, metronidazole and sulfamethoxazole had the highest residue concentrations of 7.65 ± 2.272 µg/l, 6.61 ± 0.051 µg/l and 3.88 ± 3.088 µg/l, respectively. The heavy metal concentrations obtained were below those required by Benin standards. These effluents therefore present health and environmental risks. It is then more than necessary to develop treatment methods for them before their rejection into the natural environment.
Genital Sensitivity and Perceived Orgasmic Intensity in Transgender Women with Gender Dysphoria After Gender-Affirming Surgery: A Pilot Study Comparing Pelvic Floor Evoked Somatosensory Potentials and Patient Subjective Experience
Authors: Canale Domenico , Molinaro Angelo , Marcocci Claudio , Morelli Girolamo , Matteucci Valeria , Mollaioli Daniele , Jannini Emmanuele A. , Sartucci Ferdinando 
Published: July 2022

ABSTRACT

Background
The integrity of the neural pathways that link genital sensitive areas to the brain and the correlation with subjective sensations in transgender women with gender dysphoria after gender affirming surgery (GAS) have not been explored in detail and remain controversial, so far.

Aim
To test with electrophysiology the integrity of the nervous paths after GAS, and to explore the relationship between genital sensitivity and self-perceived orgasmic intensity in transgender women after GAS.

Methods
Six patients who underwent GAS between 2016 and 2019 were enrolled in the study, and the evaluation of genital and pelvic neural pathways was performed.

Outcomes
Genital sensory thresholds (at clitoral, vaginal, and anal sites) investigated by Somatosensory Evoked Potentials (SEP) and the intensity of orgasm (measured by a psychometric tool, the Orgasmometer) were combined to obtain an objective and subjective evaluation.

Results
SSEPs confirmed the integrity of the large diameter, dorsal column-lemniscus pathway subserving the genital area after GAS. Perceptual Threshold (PT) values were much lower at the neoclitoris compared to neovagina and anal sites. There was no correlation between Orgasmometer and SEP at anal and neovaginal level, while a trend was found at clitoral level.

Clinical Implication
These findings could lead clinicians to a better understanding of postsurgical sexual life in transgender women in order to develop surgical techniques that could focus more on functional aspects of neovagina and neoclitoris.

Strengths & Limitations
Limitations: study very preliminary/exploratory; small number of patients; no long-term follow-up. Strengths: first assessment of sensory pelvic floor innervation in transgender women after GAS; use of objective methods; first attempt at correlating objectives findings to subjective experience of the sexual orgasm.

Conclusions
Our evaluation showed that SSEPs is a good indicator of neural sensitivity, especially in neoclitoris, and that these measurements were consistent with the analysis of self-perceived orgasmic intensity.
Penfield and the Founding of the National Institute of Neurological Diseases and Blindness
Authors: Leblanc Richard 
Published: July 2022

ABSTRACT:As conceived by Wilder Penfield the Montreal Neurological Institute (MNI) integrated neurology, neurosurgery, and allied disciplines within a single institution, where research and teaching complemented patient care. The MNI’s success influenced the creation of the National Institute of Neurological Diseases and Blindness (NINDB), as Pearce Bailey, its first Director, sought to replicate the MNI’s clinical and research model. He turned to MNI trainees Maitland Baldwin and Milton Shy to head the NINDB’s Surgical and Medical Neurology Branches, respectively. They in turn recruited other MNI trainees who continued their work at the NINDB bringing clinical neuroscience to the USA.
The digitization of the Brazilian national identity system: A descriptive and qualitative analysis of its information architecture
Authors: Bioni Bruno , Garrote Marina , Meira Marina , Paschoalini Nathan 
Published: July 2022

Abstract
The present paper, which composes a broader research agenda developed by Data Privacy Brasil Research Association, aims to conduct a descriptive and qualitative study of the Brazilian National Identity System through a data protection and data justice perspective. For this purpose, a desk research and legislation analyses were conducted to answer the following question: is the Brazilian National Civil Identification System (Identificação Civil Nacional or ICN) framework adequate with the Brazilian data protection general legislation and its principles—especially regarding its information architecture? As a result, we found that the current information architecture of the ICN, as well as its current use, may reveal a set of concerns related to data protection and data justice.
Intégrer des patients experts, patients partenaires, patients formateurs ou cochercheurs en cancérologie : une démocratie en santé encore incertaine
Authors: Jacques Béatrice 
Published: July 2022

RésuméEn France, la loi Kouchner (2002) a permis de repenser les droits des patients et a introduit la notion de démocratie sanitaire. En cancérologie, les associations de patients et (ex-)malades ont commencé progressivement à jouer plusieurs rôles (soutien et informations aux malades, représentation dans les institutions de soins et les agences d’État, enseignement auprès des soignants et participation à la recherche). Certains patients choisissent même d'en faire leur métier : c'est cette professionnalisation qui nous intéresse. Nous proposons ici de discuter des premiers résultats de deux recherches en cours sur le sujet.
Constructing Spaces of Discourse and ‘Regroupment’: The Case of Women’s Self-Reliant Groups in Scotland
Authors: HILL O’CONNOR CLEMENTINE , MAZZEI MICAELA , MONTGOMERY TOM 
Published: July 2022

AbstractIn liberal welfare systems, social security policy has been increasingly shifting towards conditionality and individualisation (Knotz, 2019). It is within this context that failure to meet the set conditions becomes personal rather than systemic. This has been enabled by policy discourses that construct poverty and unemployment as the result of personal failure and poor social behaviour. While this area of study over emphasises ‘the constraints imposed by discourse’ (Bacchi, 2000: 55), alternative discourses are often developed. This paper draws on ethnographic research investigating the development of self-reliant groups (SRGs) in Scotland. SRGs are small groups of women supporting each other in creating opportunities for personal development. We find that the process of involvement and sharing of experiences between women at the forefront of welfare reform led to the development of a counter public sphere. Yet, the experience doesn’t move fully towards actions for transformative social change.
Advantages and limitations of representing groups in terms of recursive utilities
Authors: Radkani Setayesh , Thomas Ashley J. , Saxe Rebecca 
Published: July 2022

AbstractGroup representations based on recursive utilities can be used to derive the same predictions as Pietraszewski in conflict situations. Additionally, these representations generalize to non-conflict situations, asymmetric relationships, and represent the stakes in a conflict. However, both proposals fail to represent asymmetries of power and responsibility and to account for generalizations from specific observed individuals to collections of non-observed individuals.
Shadow banning, astroturfing, catfishing, and other online conflicts where beliefs about group membership diverge
Authors: Suchow Jordan W. 
Published: July 2022

AbstractDrawing from conflicts observed in online communities (e.g., astroturfing and shadow banning), I extend Pietraszewski's theory to accommodate phenomena dependent on the intersubjectivity of groups, where representations of group membership (or beliefs about group membership) diverge. Doing so requires enriching representations to include other agents and their beliefs in a process of recursive mentalizing.
Comparison of sperm preparation methods to improve the recovery of mature spermatozoa in sub-fertile males
Authors: Fasano Chiara , D’Andolfi Giuseppe , Di Matteo Loredana , Forte Claudia , Dale Brian , Tosti Elisabetta 
Published: July 2022

SummaryThe integrity of chromatin in the spermatozoon is essential for reproductive outcome. The aim of this study was to evaluate the most effective and cost-effective method to reduce the percentage of spermatozoa with defects in chromatin decondensation for use in assisted reproductive technologies (ART) procedures. Sperm samples from 15 sub-fertile males were examined at CFA Naples to determine the sperm decondensation index (SDI), using the aniline blue test, before and after preparation, comparing density gradients with two different swim-up approaches. All three techniques led to a reduction in decondensed spermatozoa with no statistical difference (P > 0.05) between the control and the treated sperm. In contrast, we found a highly significant decrease in SDI (P < 0.01) after the two swim-up methods in all the samples, confirming the efficacy of these methods in lowering the percentage of chromatin compaction damage. There was no statistical difference between the two swim-up methods, however swim-up from the pellet led to improved count, motility and the percentage of normal condensed spermatozoa. We suggest that swim-up from the pellet be used in ART on sub-fertile males, both to reduce cell stress by multiple centrifugation and improve the recovery rate of mature spermatozoa.
The Physical Properties and Geochemistry of Grains on Aeolian Bedforms at Gale Crater, Mars
Authors: Weitz Catherine M. , O’Connell‐Cooper Catherine , Thompson Lucy , Sullivan Robert J. , Baker Mariah , Grant John A. 
Published: July 2022

AbstractThis study reports on the physical properties and geochemistry of aeolian bedform grains along the Curiosity rover traverse in Gale crater from Vera Rubin Ridge to the Sands of Forvie (Sols 1902–2995), and includes comparisons to results made earlier in the mission. Volumetrically, <150 μm grains dominate active aeolian bedforms in the study area, similar to previous findings elsewhere at Gale crater and at other locations on Mars. Coarser grains, up to 2.9 mm long, are present on larger active bedforms. The larger 1–3 mm active grains commonly are reddish or whitish in color and irregular in shape, suggesting erosion of local bedrock as sources. One inactive megaripple had a surface of dust‐covered 2–15 mm grains, with smaller <150 μm grains between and within the bedform interior. Geochemical measurements show element concentrations vary according to position on the bedform, sand activity, and grain contributions from local bedrock. A strong positive correlation between Mg and Ni is identified on active bedform surfaces, with the highest Ni always corresponding to ripple crests where the coarsest gray and clear grains were commonly found. There is also a correlation between Ti and Cr for the majority of active sands, with the finer active sands in ripple troughs and sand patches having the greatest number of red grains and highest Cr concentrations. These results show the smaller scale physical properties and geochemistry of several types of aeolian bedforms on Mars formed under current and ancient environments.
Wildfire Impacts on Snowpack Phenology in a Changing Climate Within the Western U.S.
Authors: Giovando Jeremy , Niemann Jeffrey D. 
Published: July 2022

AbstractSnowpack in the western U.S. is critical for water supply and is threatened by wildfires, which are becoming larger and more common. Numerous studies have examined impacts of wildfire on snow water equivalent (SWE), but many of these studies are limited in the number of observation locations, and they have sometimes produced conflicting results. The objective of this study is to distinguish the net effects of wildfires on snowpack from those of climate. We consider 45 burned sites from the Snow Telemetry network. For each burned site, unburned control sites are identified from the same level III ecoregion. Impacts of climate changes on snowpack are analyzed by comparing pre‐fire and post‐fire snow water equivalent at the unburned sites. Combined climate and wildfire effects are considered by comparing pre‐fire and post‐fire SWE at the burned sites. Wildfire impacts are then isolated by taking the difference between the burned and unburned sites. The wildfire‐induced changes in SWE are also compared to several possible controlling variables including burn severity, leaf‐area index change, dominant pre‐fire tree genus, years since the fire, and site elevation. On average, wildfires have advanced melt‐out dates 9 days and maximum SWE dates 6 days and reduced annual maximum SWE by 10% across the sites considered. On average, the combined effects of climate and wildfire have advanced melt‐out and maximum SWE dates approximately 14 and 10 days, respectively, while decreasing annual maximum SWE by approximately 10%.
Histone deacetylase 3 promotes alveolar epithelial–mesenchymal transition and fibroblast migration under hypoxic conditions
Authors: Jeong Sung Hwan , Son Eun Suk , Lee Young Eun , Kyung Sun Young , Park Jeong-Woong , Kim Se-Hee 
Published: July 2022

AbstractEpithelial–mesenchymal transition (EMT), a process by which epithelial cells undergo a phenotypic conversion that leads to myofibroblast formation, plays a crucial role in the progression of idiopathic pulmonary fibrosis (IPF). Recently, it was revealed that hypoxia promotes alveolar EMT and that histone deacetylases (HDACs) are abnormally overexpressed in the lung tissues of IPF patients. In this study, we showed that HDAC3 regulated alveolar EMT markers via the AKT pathway during hypoxia and that inhibition of HDAC3 expression by small interfering RNA (siRNA) decreased the migration ability and invasiveness of diseased human lung fibroblasts. Furthermore, we found that HDAC3 enhanced the migratory and invasive properties of fibroblasts by positively affecting the EMT process, which in turn was affected by the increased and decreased levels of microRNA (miR)-224 and Forkhead Box A1 (FOXA1), respectively. Lastly, we found this mechanism to be valid in an in vivo system; HDAC3 siRNA administration inhibited bleomycin-induced pulmonary fibrosis in mice. Thus, it is reasonable to suggest that HDAC3 may accelerate pulmonary fibrosis progression under hypoxic conditions by enhancing EMT in alveolar cells through the regulation of miR-224 and FOXA1. This entire process, we believe, offers a novel therapeutic approach for pulmonary fibrosis.
Mitoribosome insufficiency in β cells is associated with type 2 diabetes-like islet failure
Authors: Hong Hyun Jung , Joung Kyong Hye , Kim Yong Kyung , Choi Min Jeong , Kang Seul Gi , Kim Jung Tae , Kang Yea Eun , Chang Joon Young , Moon Joon Ho , Jun Sangmi , Ro Hyun-Joo , Lee Yujeong , Kim Hyeongseok , Park Jae-Hyung , Kang Baeki E. , Jo Yunju , Choi Heejung , Ryu Dongryeol , Lee Chul-Ho , Kim Hail , Park Kyu-Sang , Kim Hyun Jin , Shong Minho 
Published: July 2022

AbstractGenetic variations in mitoribosomal subunits and mitochondrial transcription factors are related to type 2 diabetes. However, the role of islet mitoribosomes in the development of type 2 diabetes has not been determined. We investigated the effects of the mitoribosomal gene on β-cell function and glucose homeostasis. Mitoribosomal gene expression was analyzed in datasets from the NCBI GEO website (GSE25724, GSE76894, and GSE76895) and the European Nucleotide Archive (ERP017126), which contain the transcriptomes of type 2 diabetic and nondiabetic organ donors. We found deregulation of most mitoribosomal genes in islets from individuals with type 2 diabetes, including partial downregulation of CRIF1. The phenotypes of haploinsufficiency in a single mitoribosomal gene were examined using β-cell-specific Crif1 (Mrpl59) heterozygous-deficient mice. Crif1beta+/− mice had normal glucose tolerance, but their islets showed a loss of first-phase glucose-stimulated insulin secretion. They also showed increased β-cell mass associated with higher expression of Reg family genes. However, Crif1beta+/− mice showed earlier islet failure in response to high-fat feeding, which was exacerbated by aging. Haploinsufficiency of a single mitoribosomal gene predisposes rodents to glucose intolerance, which resembles the early stages of type 2 diabetes in humans.
PFKFB3 regulates cancer stemness through the hippo pathway in small cell lung carcinoma
Authors: Thirusangu Prabhu , Ray Upasana , Sarkar Bhattacharya Sayantani , Oien Derek B. , Jin Ling , Staub Julie , Kannan Nagarajan , Molina Julian R. , Shridhar Viji 
Published: July 2022

AbstractPFKFB3 (6-phosphofructo-2-kinase) is the rate-limiting enzyme of glycolysis and is overexpressed in several human cancers that are associated with poor prognosis. High PFKFB3 expression in cancer stem cells promotes glycolysis and survival in the tumor microenvironment. Inhibition of PFKFB3 by the glycolytic inhibitor PFK158 and by shRNA stable knockdown in small cell lung carcinoma (SCLC) cell lines inhibited glycolysis, proliferation, spheroid formation, and the expression of cancer stem cell markers CD133, Aldh1, CD44, Sox2, and ABCG2. These factors are also associated with chemotherapy resistance. We found that PFK158 treatment and PFKFB3 knockdown enhanced the ABCG2-interacting drugs doxorubicin, etoposide, and 5-fluorouracil in reducing cell viability under conditions of enriched cancer stem cells (CSC). Additionally, PFKFB3 inhibition attenuated the invasion/migration of SCLC cells by downregulating YAP/TAZ signaling while increasing pLATS1 via activation of pMST1 and NF2 and by reducing the mesenchymal protein expression. PFKFB3 knockdown and PFK158 treatment in a H1048 SCLC cancer stem cell-enriched mouse xenograft model showed significant reduction in tumor growth and weight with reduced expression of cancer stem cell markers, ABCG2, and YAP/TAZ. Our findings identify that PFKFB3 is a novel target to regulate cancer stem cells and its associated therapeutic resistance markers YAP/TAZ and ABCG2 in SCLC models.
Health-related quality of life, psychological distress, and fatigue in metastatic castration-resistant prostate cancer patients treated with radium-223 therapy
Authors: van der Doelen Maarten J. , Oving Irma M. , Wyndaele Dirk N. J. , van Basten Jean-Paul , Terheggen Frederiek , van de Luijtgaarden Addy C. M. , Oyen Wim. J. G. , van Schelven W. Dick , van den Berkmortel Franchette , Mehra Niven , Janssen Marcel J. R. , Prins Judith B. , Gerritsen Winald R. , Custers José A. E. , van Oort Inge M. 
Published: July 2022

Abstract
Background
Radium-223 is a registered treatment option for symptomatic bone metastatic castration-resistant prostate cancer (mCRPC). Aim of this multicenter, prospective observational cohort study was to evaluate health-related quality of life (HR-QoL), psychological distress and fatigue in mCRPC patients treated with radium-223.

Methods
Primary endpoint was cancer-specific and bone metastases-related HR-QoL, as measured by the EORTC QLQ-C30 and BM-22 questionnaires. Secondary endpoints were psychological distress and fatigue, evaluated by the HADS and CIS-Fatigue questionnaires. Outcomes were analyzed for the total cohort and between subgroups (1-3 versus 4-5 versus 6 radium-223 injections). A trajectory analysis was performed to explore HR-QoL patterns over time.

Results
In total, 122 patients were included for analysis. Baseline HR-QoL, pain intensity, psychological distress and fatigue were worse in patients who did not complete radium-223 therapy. In patients who completed therapy, stabilization of HR-QoL was perceived and psychological distress and fatigue remained stable, whereas clinically meaningful and statistically significant deterioration of HR-QoL, psychological distress and fatigue over time was observed in patients who discontinued radium-223 therapy. Trajectory analysis revealed that HR-QoL deterioration over time was more likely in patients with baseline opioid use, low hemoglobin and high alkaline phosphatase levels.

Conclusions
Patients who discontinued radium-223 therapy showed worse HR-QoL, psychological distress and fatigue at baseline and more frequent deterioration of HR-QoL, psychological distress and fatigue over time when compared to patients who completed therapy. Specific attention with regard to HR-QoL during follow-up is indicated in patients with opioid use, low hemoglobin and high alkaline phosphatase levels before radium-223 therapy initiation.

Clinical trial registration number
NCT04995614.