bluuebunny/crossref_metadata_2025_split huggingface dataset:
Lutein inhibits tumor progression through the ATR/Chk1/p53 signaling pathway in non‐small cell lung cancer
Authors: Zhang Si‐yu , Lu You‐yi , He Xin‐liang , Su Yuan , Hu Fen , Wei Xiao‐shan , Pan Min‐jie , Zhou Qiong , Yang Wei‐bing 
Published: November 2022

AbstractLung cancer is the leading cause of cancer‐related death. In particular, non‐small cell lung cancer (NSCLC) accounts for approximately 85% of all lung cancer cases. Due to tumor resistance and the toxicity of chemotherapeutic agents, it is increasingly critical to discover novel, potent antitumorigenic drugs for treating NSCLC. Lutein, a carotenoid, has been reported to exert toxic effects on cells in several tumor types. However, the detailed functions and underlying mechanisms of lutein in NSCLC remain elusive. The present study showed that lutein significantly and dose‐dependently inhibited cell proliferation, arrested the cell cycle at the G0/G1 phase, and induced apoptosis in NSCLC cells. RNA‐sequencing analysis revealed that the p53 signaling pathway was the most significantly upregulated in lutein‐treated A549 cells. Mechanistically, lutein exerted antitumorigenic effects by inducing DNA damage and subsequently activating the ATR/Chk1/p53 signaling pathway in A549 cells. In vivo, lutein impeded tumor growth in mice and prolonged their survival. In conclusion, our findings demonstrate the antitumorigenic potential of lutein and reveal its molecular mechanism of action, suggesting that lutein is a promising candidate for clinical NSCLC treatment.
Reliability analysis on systems with self‐healing and self‐repairing under different environments and shock models
Authors: Li Yan , Xing Mengxue , Cai Xia 
Published: November 2022

AbstractInspired by the process of self‐healing of biological damage, high technology materials with self‐healing and self‐repairing mechanisms have been developed for high reliability and long lifetime. Therefore, the reliability modeling on intelligent systems with healing performance has become a research hotspot. Based on the diversity of healing mechanisms, this paper proposes a two‐phase reliability model method on self‐healing and self‐repairing systems. Impacts of environments, shock loads, self‐healing, and self‐repairing mechanisms are taken into account in this novel model. Besides, system lifetime and some reliability indexes under two shock models are derived, respectively. Moreover, Monte Carlo simulations are conducted to verify the accuracy of reliability under two models. Finally, an engineering case of metallized film capacitor is provided to illustrate the effectiveness and applicability of the proposed models by comparing numerical results and simulation results.
The characterization and quantification of structures of Cajanus scarabaeoides phytochemicals and their seasonal variation analysis using ultra‐performance liquid chromatography–tandem mass spectrometry
Authors: Rawat Priyanka , Singh Yatendra , Tiwari Swati , Mishra Dipak K. , Kanojiya Sanjeev 
Published: November 2022

RationaleCajanus scarabaeoides, belonging to the Fabaceae family, is an underutilized herb and traditionally used to treat several ailments. However, it is not well explored phytochemically. Therefore, mass spectrometry (MS)–based phytochemical analysis was carried out to investigate the bioactive ingredients of the herb.MethodsA ultra‐performance liquid chromatography (UPLC) coupled to photodiode array detection (PDA) and electrospray ionization (ESI) tandem mass spectrometry (UPLC‐PDA‐ESI–MS/MS) system was used for the qualitative and quantitative analysis of phytochemicals. The chromatographic separation was achieved on the Acquity BEH C18 column (150 × 2.1 mm, 1.7 μm) using a gradient system consisting of three solvents, acetonitrile, methanol, and 0.1% formic acid, used at a flow rate of 0.300 ml/min.ResultsSixteen bioactive ingredients (gallic acid, gallocatechin, epigallocatechin, catechin, procyanidin dimer, epicatechin, procyanidin trimer, isoorientin, orientin, vitexin, isovitexin, quercetin‐mono‐O‐glycoside, isoquercitrin, luteolin‐7‐O‐glucoside, quercetin, and luteolin) were identified and structurally characterized. Consequently, 12 compounds were reported for the first time from C. scarabaeoides, and 13 were quantitatively determined in different seasons. Isoorientin (10.2–7.1% w/w) and orientin (5.78–5.17% w/w) were the most abundant constituents in the dry weight of plant material, followed by vitexin and isovitexin in the rainy season.ConclusionsThe phytochemical investigation has revealed that C. scarabaeoides could be a potential alternate source of bioactive ingredients, namely, isoorientin, orientin, vitexin, and isovitexin, contributing to further exploration of its biological activity. In addition, analytical methods can be used for the rapid identification and quantification of bioactive ingredients in C. scarabaeoides.
Prevalence of Chlamydia trachomatis, Mycoplasma genitalium, and Neisseria gonorrhoeae infections in a screening program for under‐30‐year‐old pregnant women with a high participation rate in northern Spain (2016–2020)
Authors: Piñeiro Luis , Zubikarai Maitane , Manzanal Ayla , Ginto Leire , Ansa Iñigo , Lekuona Arantxa , Cilla Gustavo 
Published: November 2022

AbstractObjectiveTo assess a screening program for sexually transmitted infections (STIs) in under‐30‐year‐old pregnant women, focusing on Chlamydia trachomatis, Neisseria gonorrhoeae and Mycoplasma genitalium infections, which though often asymptomatic, may significantly affect women's health and can be vertically transmitted.DesignProspective, descriptive, observational study.SettingGipuzkoa (Basque Country, Spain).PopulationUnder‐30‐year‐old pregnant women.MethodsBetween 2016 and 2020, cervical samples were taken at first prenatal appointments from 3051 women. STIs were detected by multiplex nucleic acid amplification.Main Outcome MeasuresPrevalence of infections by age and geographical origin groups, and screening coverage.ResultsThe coverage rate was 86% between 2017 and 2020. At least one STI was detected in 5.2% of the under‐30‐year‐olds screened (95% confidence interval [CI]: 4.5%, 6.1%): C. trachomatis in 4%, M. genitalium in 1.3% and N. gonorrhoeae in 0.1%. C. trachomatis and M. genitalium prevalence rates were higher among younger women (7.2% and 2.8%, respectively in under‐25‐year‐olds), while C. trachomatis prevalence in 25‐ to 30‐year‐olds was 2.5%. C. trachomatis was more common among Latin American women (9.7% [95% CI: 7.4%, 12.3%] vs. 2.5% [95% CI: 2.0%, 3.2%] in other women). Additionally, analysing samples from 708 pregnant over‐30‐year‐old women with STI risk factors, 1.6% had at least one of the STIs studied. Notably, 20% of all cases had STI‐related symptoms or complications during pregnancy.ConclusionsThe high coverage achieved, and prevalence, clinical and epidemiological results support the view that the implementation of a screening program across Spain for C. trachomatis in under‐30‐year‐old pregnant women would be both feasible and appropriate.Tweetable abstractHigh Chlamydia trachomatis infection prevalence (4%) and coverage (>80%) in local program support pregnancy screening across Spain.
Periodic switching control under quantized state feedback based on spherical polar coordinate quantizer
Authors: Wang Jian , Yu Jiafeng 
Published: November 2022

AbstractThis article studies periodic switching control under quantized state feedback for discrete‐time linear systems. First, a novel necessary and sufficient condition is presented for the existence of stabilizing periodic switching law for the systems, by which the periodic switching law with shorter period is obtained. Second, based on this condition and by spherical polar coordinate quantizer, we give quantized state feedback control with infinite data rate for periodic switching law. From a practical point of view, we are more concerned with quantized feedback control with finite data rate, so a quantization method with finite data rate is designed for stabilizing periodic switching law under quantized state feedback. Simulation results illustrate the effectiveness of the approach.
Adaptive nonlinear control for 4‐DOF ship‐mounted rotary cranes
Authors: Wu Qiangying , Ouyang Huimin , Xi Huan 
Published: November 2022

SummaryThe swing characteristics of the load of ship‐mounted rotary cranes is very complicated, due to the rotation of the boom. Especially, when the crane is operating at sea, it is subject to some disturbances caused by waves, which makes the precise control of the load more difficult. We study the control problem of a four degree of freedom ship‐mounted rotary crane with continuous yaw and roll disturbances in this paper. Specifically, we propose an adaptive controller and the adaptive laws can be updated in real‐time depending on the state of the system and the disturbance. This method does not require linearization of the crane dynamic equations, therefore, the crane can get great control performance even if it is far from the equilibrium point. Comparative experiments demonstrate that the proposed method has excellent anti‐disturbance ability.
Thermodynamic and Kinetic Features of Bi3+ Complexes with the Azamacrocycles H4BATA and H4DOTA
Authors: Matazova Ekaterina V. , Egorova Bayirta V. , Zubenko Anastasia D. , Pashanova Anna V. , Fedorova Olga A. , Kalmykov Stepan N. 
Published: November 2022

AbstractIn current research, we determined the stability constants and kinetic properties of Bi3+ complexes with the benzoazacrown ligand H4BATA along with the H4DOTA ligand. Correct determination of the stability constants is possible when equilibrium with the free forms of the cation is observed. Unlike potentiometric titration, it is possible to apply the free‐ion selective radiotracer extraction (FISRE) method with highly stable complexes at low pH values, where the true equilibrium with the free cation forms in the solution is achieved. FISRE clarified the stability constants of Bi3+ complexes with H4BATA towards higher values. According to the UV spectroscopy data, the H4BATA ligand binds Bi3+ at room temperature within a few minutes at pH 1. We also defined the acid‐assisted mechanism of complex dissociation, where monoprotonated and deprotonated forms of the complex were found to be inert. In summary, the H4BATA ligand is highly suitable for use as a component of bismuth‐based radiopharmaceuticals.
Synthesis of Amorphous/Crystalline Hetero‐Phase Nanozymes With Peroxidase‐Like Activity by Coordination‐Driven Self‐Assembly for Biosensors
Authors: Yang Wenping , Zhu Longjiao , Yang Min , Xu Wentao 
Published: November 2022

AbstractNanozymes and amorphous nanomaterials attract great attention owing to their extraordinary properties. However, the requirements for special synthesis conditions become the bottleneck of their development. Herein, a new strategy involving the DNA‐based coordination‐driven self‐assembly is reported for the synthesis of a novel amorphous/crystalline hetero‐phase nanozyme (Fe‐DNA). For the synthesis of both nanozymes and amorphous materials, this strategy is simple and controllable, avoiding the traditionally employed harsh conditions. Benefitting from the amorphous structure and the superior physicochemical properties, the synthesized Fe‐DNA nanozyme is subsequently found to exhibit a smaller Michaelis constant value for hydrogen peroxide (H2O2) (0.81 mm) than that of horseradish peroxidase (HRP) (3.70 mm), demonstrating the stronger affinity of the Fe‐DNA nanozyme toward H2O2. The Fe‐DNA nanozyme also shows significant peroxidase‐like activity but only negligible oxidase‐like activity, a characteristic which releases the corresponding assay system from oxygen interference, thereby improving the performance of the nanozyme‐based sensing platform. In addition, compared with other nanozymes, the novel Fe‐DNA nanozyme is degradable via phosphate; thus, mitigating potential environmental threat. This work provides novel amorphous/crystalline hetero‐phase nanozymes and opens a new avenue for the design of amorphous nanomaterials and nanozymes.
Functional Rhythmic Chemical Systems Governed by pH‐Driven Kinetic Feedback
Authors: Dúzs Brigitta , Lagzi István , Szalai István 
Published: November 2022

AbstractHydrogen ion autocatalytic reactions, especially in combination with an appropriate negative feedback process, show a wide range of dynamical phenomena, like clock behavior, bistability, oscillations, waves, and stationary patterns. The temporal or spatial variation of pH caused by these reactions is often significant enough to control the actual state (geometry, conformation, reactivity) or drive the mechanical motion of coupled pH‐sensitive physico‐chemical systems. These autonomous operating systems provide nonlinear chemistry's most reliable applications, where the hydrogen ion autocatalytic reactions act as engines. This review briefly summarizes the nonlinear dynamics of these reactions and the different approaches developed to properly couple the pH‐sensitive units (e. g., pH‐sensitive equilibria, gels, molecular machines, colloids). We also emphasize the feedback of the coupled processes on the dynamics of the hydrogen ion autocatalytic reactions since the way of coupling is a critical operational issue.
Development of molecular inversion probes for soybean progeny genomic selection genotyping
Authors: Wang Haichuan , Campbell Benjamin , Happ Mary , McConaughy Samantha , Lorenz Aaron , Amundsen Keenan , Song Qijian , Pantalone Vincent , Hyten David 
Published: November 2022

AbstractIncreasing rate of genetic gain for key agronomic traits through genomic selection requires the development of new molecular methods to run genome‐wide single‐nucleotide polymorphisms (SNPs). The main limitation of current methods is the cost is too high to screen breeding populations. Molecular inversion probes (MIPs) are a targeted genotyping‐by‐sequencing (GBS) method that could be used for soybean [Glycine max (L.) Merr.] that is both cost‐effective, high‐throughput, and provides high data quality to screen breeder's germplasm for genomic selection. A 1K MIP SNP set was developed for soybean with uniformly distributed markers across the genome. The SNPs were selected to maximize the number of informative markers in germplasm being tested in soybean breeding programs located in the northern‐central and middle‐southern regions of the United States. The 1K SNP MIP set was tested on diverse germplasm and a recombinant inbred line (RIL) population. Targeted sequencing with MIPs obtained an 85% enrichment for the targeted SNPs. The MIP genotyping accuracy was 93% overall, whereas homozygous call accuracy was 98% with <10% missing data. The accuracy of MIPs combined with its low per‐sample cost makes it a powerful tool to enable genomic selection within soybean breeding programs.
Pregnancy and perinatal outcomes of early vs late selective termination in dichorionic twin pregnancy: systematic review and meta‐analysis
Authors: Sorrenti S. , Di Mascio D. , Khalil A. , Persico N. , D'Antonio F. , Zullo F. , D'Ambrosio V. , Greenberg G. , Hasson J. , Vena F. , Muzii L. , Brunelli R. , Giancotti A. 
Published: November 2022

ABSTRACTObjectiveTo evaluate outcomes of dichorionic twin pregnancies undergoing early vs late selective termination of pregnancy (ST).MethodsMEDLINE, EMBASE, CINAHL and the Web of Science databases were searched electronically up to March 2022. The primary outcome of this study was pregnancy loss prior to 24 weeks' gestation. The secondary outcomes included preterm birth (PTB) before 37, 34, and 32 weeks, preterm prelabor rupture of membranes (PPROM), gestational age (GA) at delivery, Cesarean delivery, mean birth weight, 5‐min Apgar score < 7, overall neonatal morbidity and neonatal survival. Only prospective or retrospective studies reporting data on the outcome of early (before 18 weeks) vs late (at or after 18 weeks) ST in dichorionic twin pregnancies were considered suitable for inclusion. Quality assessment of the included studies was performed using the Newcastle–Ottawa scale for cohort studies. Random‐effects head‐to‐head meta‐analysis was used to analyze the data.ResultsSeven studies reporting on 649 dichorionic twin pregnancies were included in this systematic review. The risk of pregnancy loss prior to 24 weeks was significantly lower in dichorionic twin pregnancies undergoing early compared with late ST (1% vs 8%; odds ratio (OR), 0.25 (95% CI, 0.10–0.65); P = 0.004). The risk of PTB was significantly lower in dichorionic twin pregnancies undergoing early compared with late ST when considering PTB before 37 weeks (19% vs 45%; OR, 0.36 (95% CI, 0.23–0.57); P < 0.00001), before 34 weeks (4% vs 19%; OR, 0.24 (95% CI, 0.11–0.54); P = 0.0005) and before 32 weeks (4% vs 20%; OR, 0.21 (95% CI, 0.05–0.85); P = 0.03). The mean birth weight was significantly greater in the early‐ST group (mean difference (MD), 392.2 g (95% CI, 59.1–726.7 g); P = 0.02), as was the mean GA at delivery (MD, 2.47 weeks (95% CI, 0.04–4.91 weeks); P = 0.049). There was no significant difference between dichorionic twin pregnancies undergoing early compared with late ST in terms of PPROM (P = 0.27), Cesarean delivery (P = 0.38), 5‐min Apgar score < 7 (P = 0.35) and neonatal survival of the non‐reduced twin (P = 0.54).ConclusionsThe risk of pregnancy loss prior to 24 weeks and the rate of PTB before 37, 34 and 32 weeks were significantly higher in dichorionic twin pregnancies undergoing late vs early ST, thus highlighting the importance of early diagnosis of fetal anomalies in twin pregnancies. © 2022 International Society of Ultrasound in Obstetrics and Gynecology.
EMC Design Guidelines
Authors: Keller Reto B. 
Published: November 2022

AbstractThese EMC design guidelines are here to help you understand the basics of a good design of PCBs and cabling. Good in this context means with low electromagnetic interference (EMI). The guidelines presented in this chapter are the personal guidelines of the author and helped him to pass EMC testing of several products. However, be aware that guidelines alone cannot do magical things to your design and they cannot be universally applied. Be wary! However, getting the basics right will reduce the pain of EMC testing and increase the chances of right-first-time. And that is all that we want, right?
Regulations and Standards
Authors: Keller Reto B. 
Published: November 2022

AbstractThis chapter presents the principles of EMC regulations and standards and their implications on the launch of an EMC compliant product. In addition, a way is presented on how to test EMC for global market access. The landscape of regulations, directives, and standards is constantly changing. Therefore, please check if the references made in this chapter are still valid before applying the information presented here.
Chinese Lecturers’ Pedagogical Position and Instructional Practice in EMI Teaching
Authors: Han Jinghe 
Published: November 2022

AbstractThis Chapter reports the pedagogical alignment and instructional practices contributing to the Chinese lecturers’ EMI implementation as evidenced in this research data. It counters a predominance in the current literature highlighting EMI research on language with less concern on pedagogy. Evidence of the EMI lecturers’ actual classroom instructions and their pedagogical positions were collected and analyzed. Their instruction was identified as being on the continuum between expository and constructivist teaching, with more leaning towards an expository approach in their teaching. The data disclose that the reasons for this prevalence of expository teaching are based on the lecturers’ rational choice rather than any overall attribution to their educational culture. Perceiving undergraduate education as the foundational stage of tertiary education and their self-assessment of their role as the main knowledge resource contributed to their distinctive pedagogical view and instructional practices in EMI teaching.
Chinese EMI Lecturers’ Engagement Strategies
Authors: Han Jinghe 
Published: November 2022

AbstractIn Chap. 3, the pedagogical positions and instructional practices of the EMI lecturers were analyzed. This Chapter continues the examination of actual teaching practice in EMI classes by focusing on the Chinese EMI lecturers’ specific engagement strategies. Examining engagement allows this research to respond to two concerns raised in current literature: (i) that expository pedagogy and its aligned instruction will generate less classroom engagement compared to constructivist teaching; and (ii) there is less engagement and interaction in a class when teaching is conducted in EMI. The aim of this Chapter is not to measure the effectiveness of learning in relation to engagement, but rather to capture the characteristics of the engagement strategies implemented by the participants. Data reveal a general pattern in the EMI lecturers’ implementation of engagement strategies: cognitive engagement was the dominant, most frequently used engagement strategy, and conversely, emotional, managerial and behavioral engagement was observed with very limited frequency. The arguments being proposed are that the characteristics of these Chinese EMI lecturers’ engagement strategies are shaped by their pedagogical, educational and cultural ideologies; and that English as the medium plays a secondary role in patterns of engagement observed in this research.
Application of methylene blue combined with ropivacaine intercostal nerve block in postoperative analgesia of autologous costal cartilage augmentation rhinoplasty
Authors: Guoyu Jiang , Tao Wang , Xi You 
Published: November 2022

Abstract
Objective
To observe the effect of methylene blue combined with ropivacaine intercostal nerve block on postoperative analgesia after autologous costal cartilage augmentation rhinoplasty.

Methods
In this study 100 female patients who underwent autologous costal cartilage comprehensive augmentation rhinoplasty in Chongqing Huamei Plastic Surgery Hospital from April to November 2021 were randomly divided into an experimental group and a control group, with 50 cases in each group. In the experimental group methylene blue was combined with ropivacaine intercostal nerve block as patient controlled intravenous analgesia (PCIA), and the control group was ropivacaine intercostal nerve block combined with PCIA. The visual analogue scale (VAS) scores of resting and coughing at 6 h (T1), 24 h (T2), 48 h (T3), 72 h (T4) after surgery were recorded and evaluated. At the same time, the number and times of oral analgesics were recorded as well as nausea, vomiting, burning pain and paresthesia.

Results
The VAS scores of the experimental group were lower than those of the control group at all time points. At 6 h, 24 h and 48 h after surgery, the VAS score of the experimental group was lower than that in the control group, but the difference was not statistically significant (P > 0.05). The VAS score of calm 72 h after surgery in the experimental group was significantly lower than that in the control group (P < 0.05). The analgesic effect of the two groups was better when they coughed after surgery. At 6 h after surgery, the VAS score of coughing in the experimental group was lower than that in the control group, but the difference was not statistically significant (P > 0.05); At 24 h, 48 h and 72 h after surgery, the VAS score of the coughing state in the experimental group was significantly lower than that in the control group (P < 0.05).

Conclusion
Intercostal nerve block with methylene blue combined with ropivacaine can achieve good postoperative analgesic effects in augmentation rhinoplasty with autologous costal cartilage