bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prinsip Pelancongan Berteraskan Komuniti dari Perspektif Islam
Authors: Engku Ali Engku Muhammad Tajuddin Bin , Ishak Muhammad Shahrul Ifwat , Ismail Ahmad Faizol , Abd Halim Mutia Sobihah , Abd Halim Mutia Sobihah , Baba Zaharah Salwati 
Published: January 2025

Pelancongan Berteraskan Komuniti yang melibatkan komuniti setempat secara langsung dalam semua projek pembangunan di sesebuah kawasan yang terbabit merupakan salah satu daripada cabang pelancongan yang terdapat di Malaysia. Ia mampu memberikan peluang kepada komuniti setempat untuk mengurus, mengembangkan dan mencapai peningkatan taraf kehidupan mereka. Terdapat enam prinsip utama dalam Pelancongan Berteraskan Komuniti iaitu penglibatan komuniti, sensitiviti budaya, kemampanan alam sekitar, manfaat ekonomi untuk komuniti, menghormati hak asasi manusia dan pendidikan serta pembangunan kapasiti. Kesemua prinsip-prinsip penting ini digariskan untukmemperkasakan lagi industri Pelancongan Berteraskan Komuniti. Dalam waktu yang sama tiada analisis Syarak dilakukan untuk mengetahui keserasian prinsip-prinsip ini dengan ajaran Islam. Kajian ini bertujuan untuk menganalisis prinsip-prinsip ini dari perspektif Islam. Kajian ini adalah kajian kualitatif. Data dalam kajian ini dikumpul dari sumber primer dan sekunder termasuklah buku, artikel dan dokumen. Data yang diperolehi dianalilsis menggunakan teknik analisis data. Hasil kajian mendapati prinsip-prinsip Pelancongan Berteraskan Komuniti mempunyai asasnya dalam Syariat. Asas Syarak kepada penganjuran pemeliharaan terhadap prinsip-prinsip ini bolehlah disimpulkan pada tiga konsep utama iaitu tolong menolong dalam kebaikan dan ketakwaaan, menghormati manusia dan alam dan peningkatan diri ke arah yang lebih baik. Prinsip penglibatan komuniti terkandung dalam konsep tolong menolong dalam kebaikan dan ketakwaan. Prinsip sensitiviti budaya dan kemampanan alam sekitar pula terangkum dalam konsep menghormati manusia dan alam. Konsep peningkatan diri ke arah yang lebih baik pula merangkumi prinsip manfaat ekonomi kepada komuniti dan konsep pendidikan serta pembangunan kapasiti. Kesemua konsep ini pula tertakluk kepada syarat patuh Syariah.
The Da'wah Approach of Badiuzzaman Said Nursi: A Preliminary Analysis Bsed on Bottom-up Strategi
Authors: Mohamed Saniff Shereeza , Mohd Nurhazwani 
Published: January 2025

The bottom-up strategy is an initiative done at the grassroots level with its own approach. Policy development, decision-making and implementation are carried out independently by such grassroot approach. In the field of da'wah, the bottom-up strategy represents an approach that is mobilized internally based on the formation of a community that has the right to determine their affairs. The bottom-up strategy is seen as a necessity in delivering da‘wah as such an approach encourages development and collective awareness as well as upholding the concept of balanced development from both the spiritual and material points of view. Therefore, this paper attempts to discuss the da‘wah approach of a religious figure, namely Badiuzzaman Said Nursi from the bottom-up strategy’s perspective. The study was conducted in relation to the bottom-up strategy related to the concept of reform and the approaches of da‘wah by Badiuzzaman Said Nursi. This study is carried out based on a review of literature with content analysis as the tools of analysis. The findings suggest that Badiuzzaman Said Nursi's approach to da‘wah fits in well within the ambit of bottom-up strategy which, although was not well received initially from the political powers of the day, nonetheless exhibits sustaining features which has proven its relevance to surpass beyond his time as his message survives and is used as a guide by heads of state and the society until this day.
PRODUKSI PROGRAM DAKWAH DI CHANAL YOUTUBE
Authors: Bob Andrian Bob Andrian , Doni Rifansyah Doni Rifansyah , Pilga ayong Sari Pilga ayong Sari 
Published: January 2025

This research is related to the production process carried out by the Munzalan TV youtube channel on the dawn program reaching blessings. The focus of this research is to find out how the production process is carried out from pre-production to post-production carried out by Munzalan TV. The approach used in this study is to use a qualitative approach with a descriptive method. In collecting data, researchers use several techniques, namely observation, interviews and documentation. The research was carried out at the mosque of the munzalan ship indinesia Road. Sungai Raya in Gg. Imaduddin, West Kalimantan, Indonesia. The results of this study are to describe how the production process includes pre-production, production and post-production carried out by Munzalan TV On the dawn program to achieve blessings. In general, the results of this study show that the production process carried out by Munzalan TV uses three stages, the first pre-production at this stage the first is syuro, then prepare room control, prepare production equipment at this stage the image director must set the exposure segitigs, then prepare the sound, the next stage of production, at the time of production carried out is to prepare Youtube straming using sofwara vMix, then for the production image director no longer do the camera settings have stayed in one direction only, then the sound control that is carried out by the mosque takmir and connects to the soundcar which is the responsibility of the stramer and for the stylist cahata control there is no lightingman because hanaya uses mosque lighting, at the time of production also do records that are part of post-production, In the post-production stage, what is done is editing and airing.
Video Game Therapy in a Neurosciences Critical Care Unit: A Pilot Study
Authors: Ziegler Megan , Kumble Sowmya , Zink Elizabeth K. , Tahara Nozomi , Vora Isha , Stevens Robert D. , Bahouth Mona N. 
Published: January 2025

Background
Therapeutic activity after stroke is a component of early recovery strategies. Interactive video games have been shown to be safe as an adjunct rehabilitation therapy in the medical intensive care setting, but patients with neurologic disease were often excluded from those protocols.

Objectives
To evaluate the feasibility and safety of individualized interactive video game therapy in critically ill neurologic patients.

Methods
Adults admitted to the neurosciences critical care unit during the observation period were eligible for inclusion. Wii sports games with the potential to target common neurologic deficits were categorized by our interprofessional team. We collected information regarding the number of sessions attempted, time for setup, indications of use, patient/staff experience, and predefined safety events.

Results
Twelve sessions were completed in 9 patients, mean (SD) age 48.6 (18.1) years, and sessions were led by nursing and therapy teams. Prescribed video game therapy sessions targeted the following recovery domains: coordination (70%), balance (50%), endurance (30%), cognition (30%), fine motor control (30%), neglect (20%), engagement in activity (10%), and vision (30%). On average, 4.7 minutes were spent for setup and 18.8 minutes were spent playing video games. No safety issues were identified. All patients indicated that they enjoyed participating in video game therapy.

Conclusions
In this pilot study, prescriptive interactive video game therapy in early rehabilitation was feasible and safe in the neurosciences critical care setting. Video game therapy may be a valuable complement to existing rehabilitation for critically ill neurologic patients and warrants validation in a larger patient sample.
Impact of Plant Growth Regulators on Salad Cucumber (<em>Cucumis sativus</em> L.) Vine Length and Yield
Authors: Perera U. D. T. , Kumarasinghe H. K. M. S. 
Published: January 2025

Training of salad cucumber vines is a very labour and time-consuming task. Therefore, this study was conducted to investigate the impact of plant growth regulators(PGRs) on the length and yield of salad cucumber vines. The experiment al design used was a Completely Randomized Design with four replicates. T1=Cycocel (0.4375 ml/L water), T 2=Sodium Nitrophenolate (0.4 ml/L water), T3=Ethephon (0.325 ml/L water), T4=Paclobutrazol(250 mg/L wate r), and T5=Without PGRs (control) were the five treatments. Treatments were applied once a week. Growth parameter s were recorded weekly while yield parameters were recorded at harvest. Data were analyzed by ANOVA using the SAS software. Subsequently, means were separated by Dunnett’s test. Results revealed that the vine lengths were significantly low from the treatments T3 (Ethephon , 251 cm) and T4 (Paclobutrazol, 166.33 cm). The number of leaves per vine was significantly highest from T3 (Ethephon, 56 leaves) and T4 (Paclobutrazol, 42 leaves) produced the significantly lowest number of leaves per vine. Additionally , the significantly lowest length of internodes for the 14th and 21st internodes resulted from T3 (Ethephon, 3.36 cm, 3.33 cm) and T4 (Paclobutrazol, 2.96 cm, 3.33 cm). The significantly lowest leaf area in the 15th leaf resulted from T4 (P aclobutrazol, 321.86 cm2) while the significantly highest leaf area in the 30th leaf resulted from T3 (Ethephon, 303.64 cm2). Furthermore, a significantly higher number of nodes per 1 m of vine length was reported from T3 (Ethephon, 17.66 nodes) and T4 (Paclobutrazol, 20 nodes). In terms of yield parameters, the significantly lowest fruit weight (530.33 g), length (13.45 cm), and number of fruits (5.66) wer e recorded from T3 (Ethephon). Thus, T4 (Paclobutr azol) is suitable for shortening the vine length along with a greater yield of salad cucumber vines.
Genetic modulators of diversity in biological expression of sickle cell anemia in patients from democratic republic of Congo
Authors: NGOLE MAMY , NGOLE MAMY , MBAYABO GLOIRE , LUMBALA PAUL , RACE VALERIE , MVUAMA NONO , DEMAN STEPHANIE , SOUCHE ERIKA , TSHILOBO LUKUSA PROSPER , VAN GEET CHRIS , DEVRIENDT KOENRAAD , MATTHIJS GERT , LUMAKA AIME , CLEYNEN ISABELLE 
Published: January 2025

Background: So far, the fetal hemoglobin (HbF) level is the most recognized modulator of sickle cell anemia (SCA) clinical expression. Variability in the HbF levels is associated with the SCA haplotypes and quantitative trait loci identified by Genome-Wide Association Studies (GWAS).
Key words: sickle cell anemia, DR Congo, SCA haplotypes, HbF, single nucleotide polymorphisms
Trophoblast cell surface antigen 2 expression in scalp basal cell carcinomas: does it differ from the facial basal cell carcinomas location?
Authors: Elkhamisy Fatma Alzahraa A. , Eesa Ahmed N. , Abd El-Moeze Nadia A. 
Published: January 2025

Background
Scalp basal cell carcinomas (sBCC) exhibit greater aggressiveness than facial BCC (fBCC), leading to a poorer prognosis. Investigating the involvement of trophoblast cell surface antigen 2 (TROP2) in sBCC could provide valuable insights into its pathogenesis and potentially uncover novel therapeutic avenues for managing challenging sBCC cases.

Objective
This study aimed to investigate the expression of TROP2 in sBCC versus fBCC to enhance the understanding of sBCC and elucidate the role of TROP2 in BCC progression.

Methods
This comparative cross-sectional study assessed TROP2 immunohistochemical expression in sBCC versus fBCC lesions. Mean expression scores, determined through ImageJ analysis based on area percentage, were compared between the two groups. Statistical analysis was conducted to evaluate the relationship between TROP2 expression and clinicopathological criteria in both sBCC and fBCC.

Results
The study included 40 cases of BCC, with 19 (47.5%) allocated to sBCC and 21 (52.5%) to fBCC. Scalp BCC cases demonstrated significantly lower age, larger tumor size, and a higher proportion of females than fBCC cases. TROP2 expression was significantly higher in sBCC than in fBCC. TROP2 expression positively correlated with aggressive histology in both groups. Histological type emerged as an independent factor influencing TROP2 expression at both anatomical sites, while tumor size independently affected TROP2 expression, specifically in sBCC cases.

Conclusion
sBCC exhibits distinctive clinicopathological features compared with fBCC. The higher TROP2 expression in sBCC may account for its documented aggressive nature compared with fBCC. Anti-TROP2 targeted therapy might have a promising role in treating challenging sBCC cases and merits further investigation.
Assessment of serum enhancer of zeste homolog 2 in atopic dermatitis patients in Suez Canal University Hospitals and its correlation with disease severity
Authors: Tawfika Noha Z. , Gomaaa Amal H.A. , El-Hamid Marwa A. , Abd El-Fadeal Noha M. 
Published: January 2025

Background
The pathophysiology of atopic dermatitis (AD) remains poorly defined inspite of recent advances in the understanding of the genetics of AD. Two main hypotheses have been proposed as regard the development of inflammation that leads to AD. According to the previous data from different studies about the role of enhancer of zeste homolog 2 (EZH2) in allergic diseases, we suspect that it may has a role in pathogenesis of atopic dermatitis.

Aim
The early diagnosis of AD through assessing the serum level of EZH2 and its correlation with disease severity.

Patients and methods
This case-control study was performed on two groups. The first group included 30 AD patients; the second group included 30 healthy volunteers matched for age and sex. The serum EZH2 level was evaluated.

Results
Regarding EZH2 serum level, there was a statistically significant difference between the two groups, with AD patients having a higher level. There was a statistically significant difference between serum EZH2 level and disease severity. Serum EZH2 had a significant direct strong correlation with the Scoring Atopic Dermatitis index.

Conclusion
In this study, EZH2 serum level was significantly higher in patients with AD. Thus, EZH2 may have a role in immune dysregulation encountered in AD and may act as an important predictor for AD severity.
Efficacy and safety of Oxalobacter formigenes in patients with primary hyperoxaluria: A systematic review and meta-analysis of randomized controlled trials
Authors: Khan Ubaid , Mubariz Muhammad , Rezq Hazem , Mahmoud Abdelrahman , Moiz Nasir Muhammad , Ul Ain Noor , Bazai Umar Khan , Khan Maleeka Zamurad , Abuelazm Mohamed 
Published: January 2025

ABSTRACT

Background and Objective:
Primary hyperoxaluria (PH), a rare autosomal recessive disorder, results in defective metabolism of oxalate, leading to increased oxalate levels. Oxalobacter formigenes (O. formigenes) is a nonpathological anaerobic bacterium that uses oxalate for its survival and thus decreases the plasma oxalate levels. We aimed to use randomized controlled trials (RCTs) to evaluate the efficacy of O. formigenes in treating PH.

Methods:
A literature review was conducted for synthesizing the evidence from RCTs on Scopus, Web of Science, Embase, PubMed, and CENTRAL until January 2023. The outcomes were pooled using mean difference (MD) for continuous data and odds ratios (OR) for dichotomous data along with confidence interval (CI). The systematic review is registered with Prospero ID CRD42023404421.

Results:
We included five RCTs with 208 patients. The pooled analysis did not favor O. formigenes over placebo in reducing the plasma oxalate levels (MD: −0.00 mmol/day; 95% CI: [ − 0.01–0.00]; P = 0.06). Similar results were observed for urinary oxalate levels (MD: −0.01 mmol/day; 95% CI: [ − 0.12–0.10]; P = 0.86). There were no significant adverse events (OR: 0.44; 95% CI: [0.14–1.39]; P = 0.16) or serious adverse events (OR: 0.80; 95% CI: [0.29–2.25]; P = 0.67).

Conclusion:

O. formigenes was ineffective in reducing the serum and urine oxalate levels in patients with PH but has an acceptable safety profile. As PH is a relatively rare disease and few patients consent for the trials, stringent protocols are required in the future to achieve data accuracy pertinent for making conclusive recommendations on the efficacy of O. formigenes in patients with PH.
Utilization of eye care services among adults in a rural community in Rivers State South-South, Nigeria
Authors: George Datonjo Alwell , Nathaniel Godswill Inye 
Published: January 2025

Background:
The aim of this study was to assess the awareness and utilization of eye care services among adults aged 40 years and above in Ndele, Rivers State.

Materials and Methods:
It was a community-based descriptive cross-sectional study carried out in Ndele, Rivers State. Eligible subjects were selected using the multistage random sampling method. An interviewer-based self-structured questionnaire was administered to each participant following which ocular examination was performed. Information collected included demographic characteristics, knowledge of available eye care facilities, previous use of eye care services, and barriers to the use of eye care services. Data obtained were analyzed using the statistical package SPSS version 20. Pearson Chi-square test was used to test the relationship between variables. P < 0.05 was considered a statistically significant association between variables.

Results:
Four hundred and twenty-five subjects participated in the study made up of 240 males (56.5%) and 185 females (43.5%), with an M:F ratio of 1:1.3. The age range was 40–88 years, and the mean age of the subjects studied 53.6 ± 11.2 years. Findings showed that awareness of available eye care services was good 69.2%, whereas utilization of such services was very low 23.1%. Better awareness and rate of utilization were found with a higher level of education (P < 0.001), whereas no significant statistical relationship was found for age (P = 0.245) and sex (P = 0.394) in awareness and age (P = 0.415) and sex (P = 0.089) in utilization. Cost of care was the major reason found for nonutilization of the eye care services.

Conclusion:
In the studied population, although the awareness of eye care services in the community was good, the utilization of the services was very low, and the cost of care was the major factor reducing utilization. Therefore, there was a need to subsidize the cost of services by the government to improve uptake which will further reduce the magnitude of avoidable blindness in Ndele, Rivers State.
Assessing the role of blood glucose levels on intraocular pressure during pre- and postprandial phase in diabetic patients
Authors: Acharya Pavana , Kavitha C. V. , Nayana P. K. , Sandeep K. , Narayan Rathod Vishakha , Anusha K. S. 
Published: January 2025

Purpose:
The purpose of this study was to evaluate the changes in intraocular pressure (IOP) during pre- and postprandial phase of blood glucose estimation and to compare the changes in IOP between well-controlled and uncontrolled diabetics.

Subjects and Methods:
Three hundred patients with diabetes were assessed for IOP changes in the preprandial phase and postprandial phase. Patients were divided into uncontrolled and controlled diabetes groups based on hemoglobin A1c levels, and IOP changes in pre- and postprandial phase were compared between these two groups.

Results:
Among 300 patients in our study, the mean age was 63.29 ± 9.88 years. About 41.3% of our study population were males (124 patients), and 58.7% were females (176 patients). Out of 300 patients, 65 (21.7%) patients fall under the uncontrolled diabetes group. The average IOP in preprandial phase was 14.34 ± 2.25, and the average IOP in postprandial phase was 14.88 ± 2.26 (P = 0.001). The average IOP in preprandial phase of well-controlled diabetes group is 14.05, and the average IOP in postprandial phase is 14.48 (P = 0.001). The average IOP in the uncontrolled group in preprandial phase was 15.81, and the average IOP in postprandial phase was 16.37 (P = 0.001).

Conclusion:
Diabetic patients with uncontrolled diabetes showed significantly raised IOP compared to well-controlled diabetics. There is a statistically significant rise in IOP in postprandial phase of all subjects compared to their preprandial phase. Our study’s inclusion of central corneal thickness-corrected IOP has demonstrated that, in addition to influencing corneal thickness, hyperglycemia also affects aqueous humor dynamics.
Regional variation of risk factors among diabetic retinopathy patients in India: Findings from the INDO EYE study
Authors: Pillai Gopal S , Sinha Bibhuti Prassan , Sheeba C. S. , Barman Manabjyoti , Sen Alok , Sundaram Natarajan , Dickson Merin , Salim Ashid , Paul Geethu , KrishnanNair Deepthi Geetha , Choudhury Manjisa , Kumar Aniket , Jangidm Poonam , Abhilash Anjana 
Published: January 2025

Context:
Diabetic retinopathy (DR) is a major cause of vision impairment among diabetics, with significant regional variations in its prevalence and associated risk factors across India.

Aims:
This study aims to assess the variation in risk factors for DR, including demographic and behavioral characteristics, and to identify regional differences in the severity of DR across four geographic zones in India.

Settings and Design:
Data were sourced from the INDO EYE registry, encompassing six tertiary eye care hospitals across India. The study was designed to analyze and compare DR-related variables among different geographic zones: south, central, west, and east.

Subjects and Methods:
The study analyzed data from 7112 eyes of 3699 patients diagnosed with DR. Demographic, clinical, and behavioral data were collected, including age, gender, substance abuse history, comorbidities, and DR severity

. Statistical Analysis Used:
Descriptive statistics summarized demographic and clinical characteristics. Chi-square tests assessed associations between categorical variables, and one-way ANOVA evaluated continuous variables across zones. Statistical significance was set at P < 0.05, with analysis performed using the IBM SPSS Statistics 28.

Results:
The study revealed significant regional differences in DR severity and risk factors. The central zone had the highest proportion of proliferative DR and diabetic macular edema, while the south and west zones showed better visual outcomes and higher proportions of certain comorbidities. The east zone exhibited higher substance abuse rates and a broader range of visual acuity outcomes.

Conclusions:
Regional disparities in DR prevalence and severity highlight the need for targeted public health strategies to address local risk factors and improve diabetes management across India. Enhanced healthcare access and tailored interventions are crucial for reducing DR-related vision loss.