bluuebunny/crossref_metadata_2025_split huggingface dataset:
Drug Repurposing for Cancer Therapy in the Era of Precision Medicine
Authors: K.W. To Kenneth , Cho William C.S. 
Published: February 2022

Abstract:
Drug repurposing refers to the identification of clinically approved drugs with the known safety profiles and defined pharmacokinetic properties for new indications. Despite the advances in oncology research, cancers are still associated with the most unmet medical needs. Drug repurposing has emerged as a useful approach for the search for effective and durable cancer treatment. It may also represent a promising strategy to facilitate precision cancer treatment and overcome drug resistance. The repurposing of non-cancer drugs for precision oncology effectively extends the inventory of actionable molecular targets and thus increases the number of patients who may benefit from precision cancer treatment. In cancer types where genetic heterogeneity is so high that it is not feasible to identify strong repurposed drug candidates for standard treatment, the precision oncology approach offers individual patients access to novel treatment options. For repurposed candidates with low potency, a combination of multiple repur-posed drugs may produce a synergistic therapeutic effect. Precautions should be taken when combining repurposed drugs with anticancer agents to avoid detrimental drug-drug interactions and unwanted side effects. New multifactorial data analysis and artificial intelligence methods are needed to untangle the complex association of molecular signatures influencing specific cancer subtypes to facilitate drug repur-posing in precision oncology.
User Engagement and Assessment of Treatment Effectiveness in Patients Using a Novel Digital mHealth App During Spinal Cord Stimulation Screening Trials
Authors: Lee Jennifer M , Woon Rex , Ramsum Mandy , Halperin Daniel S , Jain Roshini 
Published: February 2022

Background
Patient outcomes and experience during a Spinal Cord Stimulation (SCS) screening trial can have a significant effect on whether to proceed with long-term, permanent implantation of an SCS device for the treatment of chronic pain. Enhancing the ability to track and assess patients during this initial trial evaluation offers the potential for improved understanding regarding the suitability of permanent device implantation as well as identification of the SCS-based neurostimulative modalities and parameters that may provide substantial analgesia in a patient-specific manner.

Objective
In this report, we aimed to describe a preliminary, real-world assessment of a new, real time tracking, smart, device-based digital app used by patients with chronic pain undergoing trial screening for SCS therapy.

Methods
This is a real-world, retrospective evaluation of 13,331 patients diagnosed with chronic pain who used the new “mySCS” mobile app during an SCS screening trial. The app design is health insurance portability and accountability act (HIPAA)-compliant and compatible with most commercially available smartphones (eg, Apple, iPhone, and Android). The app enables tracking of user-inputted health-related responses (ie, pain relief, activity level, and sleep quality) in addition to personal trial goals and a summary of overall experience during the SCS trial. A deidentified, aggregate analysis of user engagement, user-submitted responses, and overall trial success was conducted.

Results
When provided the opportunity, the percentage of users who engaged with the tracking app for ≥50% of the time during their trial was found to be 64.43% (n=8589). Among the 13,331 patients who used the app, 58.24% (n=7764) entered a trial goal. Most patients underwent SCS screening with a trial duration of at least 7 days (n=7739, 58.05%). Of those patients who undertook a 7-day SCS trial, 62.30% (n=3456) engaged the app for 4 days or more. In addition, among all who submitted descriptive responses using the app, health-related improvements were reported by 77.84% (n=10,377) of patients who reached day 3 of the screening phase assessment and by 83.04% (n=11,070) of those who reached trial completion. A trial success rate of 91% was determined for those who used the app (versus 85% success rate for nonusers).

Conclusions
Data from this initial, real-world examination of a mobile, digital-health–based tracking app (“mySCS”), as used during the SCS screening phase, demonstrate that substantial patient engagement can be achieved while also providing for the acquisition of more real time patient-outcome measures that may help facilitate improved SCS trial success.
Effect of Gender and Cause of Injury on Incidence of Cranial Nerves Injuries in Maxillofacial Trauma; A Clinical Study
Authors: Al-jubory Abdulkareem Jadaan 
Published: February 2022

Objectives: To document the incidence and pattern of cranial nerves injuries that occur in association with maxillofacial trauma for early diagnosis and management.
Methods: This study done from April 2012 to April 2013 in AlË—Salaam teaching hospital in Mosul/Iraq. We studied 367 patients presented with maxillofacial trauma. The demographic, medical information and cause of injury are recorded for each patient. Clinical examination of the cranial nerves was done at time of admission. Plain x-ray film, CT scan, electromyography, Hess chart and other investigations were done when clinically indicated.
Results: 367 patients presented with maxillofacial trauma included in this study. 57(15.5%) patients presented with cranial nerves injuries. 47(82.45%) patients are males and 10(17.54%) are females. The mean age of the patients is (25 years). 45(78.94%) patients had single nerve injury.12 (21.05%) patients presented with multiple cranial nerves injuries. The facial nerve carries the highest rate of incidence.
Conclusions: Cranial nerves injuries most commonly detected in young age group male patients. High velocity missile significantly increase the chance of cranial nerves injuries. Early diagnosis of these injuries essential for better results with less morbidities and residual deformities.
Ewing sarcoma of the kidney; a rare case report
Authors: Alharganee Anmar , Alabidi Haydar , Alkubaisi Sarah 
Published: February 2022

Kidney cancer is considered as one of the commonest urological malignancies globally. Primitive neuroectodermal tumor and ewing sarcoma pathology are commonly found bone cancers within the daily clinical practice especially in adulthood.
In this article we will discuss a rare case report of ewing sarcoma family variant (ESFV) within the renal pelvis. Chemotherapeutic and radiation protocols already used in bone ewing sarcoma have been exploited to treat this variant pathological malignancy in the kidney considering the metastatic presentation of the case. Hence, the response to some of these management lines was obvious during follow up appointments. Unfortunately, side effects were so severe especially the hematological adverse events. By conclusion, the administration of the same protocols as for bone ewnig sarcoma should be discussed carefully in treatment selection.
Psikopat: Ciri, Penyebab dan Solusinya dalam Islam
Authors: NK Mahdi 
Published: February 2022

This article describes psychopaths related to the characteristics, causes, and solutions to overcome them in Islamic teachings. In completing this article, the author uses a qualitative approach, namely by studying literature or reviewing literature related to psychopaths and the teachings of Islam. This study identifies three factors that cause psychopathic behavior: genetic, environmental, and traumatic factors. The solution in Islam is to read the Qur'an, pray at night, hang out with pious people, fast, and remember. These five actions are known as Islamic psychotherapy, which can overcome psychopathic behavior.
Abstrak
Artikel ini bertujuan untuk mendeskripsikan tentang psikopat yang berkaitan dengan ciri-ciri, penyebab, dan solusi untuk mengatasinya dalam ajaran Islam. Dalam menyelesaikan artikel ini, penulis menggunakan pendekatan kualitatif yaitu dengan studi literatur atau kajian kepustakaan yang berkaitan dengan psikopat dan ajaran agama Islam. Kajian ini mengidentifikasi bahwa terdapat tiga faktor yang menyebabkan perilaku psikopat yaitu faktor genetik, lingkungan, dan traumatis. Adapun solusinya dalam Islam adalah dengan membaca al-Qur’an, Shalat malam, Bergaul dengan orang saleh, Puasa, dan Zikir. Kelima tindakan tersebut dikenal dengan istilah psikoterapi Islam yang dapat digunakan untuk mengatasi perilaku psikopat.
Rekonstruksi Desain Kegiatan Laboratorium Berbasis ANCORB Pada Materi Hereditas
Authors: Kusnandar Maulana Ari , Supriatno Bambang Supriatno , Anggraeni Sri Anggraeni 
Published: February 2022

Experiment method is suitable learning method for biology’s learning. Experiment method requires a guide in the form of student worksheets, so the experiment method can be implemented and in accordance with the objectives of learning. This research seeks to (1) obtain an overview concerning the suitability of practicum objectives stated in DKL with the basic competences stated in the curriculum, (2) obtain an overview concerning the suitability of practicum objectives with steps in DKL, (3) obtain an overview concerning the practicum objectives, concepts/principles, in DKL, (4) find out whether the steps in DKL guide students to perform knowledge construction. This research implemented descriptive qualitative method with ANCORB stages, consisting of (1) Analysis, (2) Trial, and (3) Reconstruction. The analysis was carried out by paying attention to conceptual, practical, and knowledge construction aspects. The research object consisted of 8 LKPDs on genetics buttons practicum sourced from various books made by teachers, selected through purposive sampling. The research results revealed that those LKPDs are not feasible to use, do not meet the ideal score, and do not meet the criteria stated on diagram fee.
Abstrak. Metode praktikum merupakan metode belajar yang sangat tepat untuk pembelajaran biologi. Dalam praktikum biologi diperlukan panduan berupa lembar kerja peserta didik agar praktikum dapat dilaksanakan dan sesuai dengan tujuan pembelajaran Tujuan dari penelitian ini adalah (1) memperoleh gambaran mengenai kesesuaian tujuan praktikum yang terdapat pada DKL dengan kompetensi dasar pada kurikulum, (2) mengetahui gambaran kesesuaian antara tujuan praktikum dengan langkah-langkah pada DKL, (3) mengetahui gambaran mengenai tujuan praktikum prinsip/konsep pada DKL, (4) untuk mengetahui apakah langkah-langkah pada DKL sudah dapat mengarahkan siswa terhadap kontruksi pengetahuan. Metode yang digunakan dalam penelitian ini adalah deskriptif kualitatif dengan tahapan ANCORB, yaitu (1) Analisis, (2) Uji Coba, (3) Rekontruksi. Analisis dilakukan dengan memperhatikan 3 aspek, yaitu aspek konseptual, aspek praktikal dan aspek kontruksi pengetahuan. Objek penelitian menggunakan 8 LKPD mengenai praktikum kancing genetika yang berasal dari berbagai buku dan yang dibuat oleh guru disekolah yang dipilih secara purposive sampling. Berdasarkan hasil analisis yang telah dilakukan terhadap 8 LKPD belum layak digunakan dan tidak memenuhi skor ideal dan belum memenuhi kriteria pada diagram fee.
Upaya Meningkatkan Hasil Belajar Atletik Menggunakan Pendekatan Metode Student Centered Learning (SCL) Model Case Method pada Mahasiswa Porkes FKIP UNJA
Authors: Sukendro Sukendro , Yuliawan Ely 
Published: February 2022

Tujuan penelitian ini adalah untuk mengetahui peningkatan hasil belajar Atletik melalui pendekatan Metode Student Centered Learning (SCL) Model Case Method. Jenis penelitian ini adalah penelitian tindakan kelas (PTK), dengan dua siklus. Instrumen yang digunakan penelitian ini adalah pada matakuliah Atletik pada nomor Lompat Jauh. Subjek dalam penelitian ini adalah mahasiswa semester I PORKES yang berjumlah 36 mahasiswa. Teknik analisis data yang digunakan adalah statistik deskriptif dengan persentase. Berdasarkan hasil penelitian pada diperoleh hasil tes Lompat Jauh pada matakuliah atletik melalui pendekatan Metode Student Centered Learning(SCL) Model Case Method diperoleh ketercapaian pada siklus 1 sebesar 51,3% dengan nilai rata-rata 66,64. Pada siklus 2 terlihat peningkatan hasil belajara sebesar 92,31% dengan rata-rata nilai 76,64. Sehingga dapat disimpukan ada peningkatkan sebesar 41,02 terhadap hasil belajar melalui pendekatan .
Kata Kunci : Atletik, Student Centered Learning
Analisis Kemampuan Pukulan Backhand Tenis Meja Pada Atlet Junior Putra PTM Rajawali Club
Authors: Mardianto Heru 
Published: February 2022

Tujuan penelitian ini untuk mengetahui tingkat kemampuan backhand tenis meja pada atlet junior putra PTM Rajawali Club.Peneletian ini merupakan penelitian deskriptif. Teknik pengumpulan data yang digunakan adalah metode survei dengan instrument tes dan pengukuran. Instrumen yang digunakan yaitu tes kemampuan backhand backboard test dan tes kemampuan backhand tenis meja. Teknik analisis data yang digunakan dalam penelitian ini adalah menggunakan statistik deskriptif.Hasil penelitian menunjukkan bahwa tingkat kemampuan backhand backboard test tenis meja pada atlet junior putra PTM Rajawali Club yang kategori sangat baik sebanyak 9 orang dengan persentase sebesar 90%, kategori baik sebanyak 1 orang dengan persentase 10%. Berdasarkan hasil penelitian dan pembahasan yang telah dilakukan, maka dapat disimpulkan bahwa hasil kemampuan pukulan backhand pada permainan tenis meja atlet junior putra PTM Rajawali Club terdapat tingkatan yang baik
Pengaruh Latihan Passing Bawah ke Dinding dan Berpasangan Terhadap Keterampilan Bola Voli pada Siswa Ekstrakurikuler di SMP Negeri 13 Tanjung Jabung Timur
Authors: Setia Budi Ahmad 
Published: February 2022

Keterampilan dasar bermain bolavoli adalah sebuah drajat kemampuan untuk melakukan sesuatu teknik dasar permainan bolavoli secara efektif dan efesien yang ditentukan oleh adanya kecepatan, ketepatan, bentuk, dan kemampua dalam menyesuaikan diri. Passing bawah ke dinding adalah dilakukan dengan cara memantulkan bola kedinding dan badan harus dalam keadaan siap untuk melakukan passing, Sikap permulaan pemain memegang bola dengan kedua tangan menghadap dinding, pelaksanaannya bola dilemparkan atau dipantulkan kedinding dan pantulannya berusaha untuk di passing ketembok sasaran lagi demikian seterusnya. Passing bawah berpasangan bola dilempar salah satu kemudian di passing bawah diarahkan kepada lawannya, setelah melakukan passing bawah posisi tetap menunggu datang bola dari lawan kemudian diarahkan lagi begitu seterusnya.Metode yang digunakan dalam penelitian ini yaitu kuantitatif eksperimen, yakni suatu penelitian dimana peneliti memberikan perlakuan setelah diambil tes awal dan akan kembali diambil tes akhir setelah diberi perlakuan kemudian akan terlihat apakah variabel bebas berperan terhadap timbulnya suatu gejala, Sampel dalam penilitian ini berjumlah 12 orang. Latihan yang diberikan dilakukukan selama 16 kali pertemuan.Kesimpulan dari skripsi ini adalah uji statistik t hitung lebih besar dari pada t tabel atau (12.5) > (1.79588), jadi terdapat pengaruh latihan passing bawah kedinding dan berpasangan terhadap keterampilan passing bawah bola voli pada siswa ekstrakurikuler di SMP Negeri 13 Tanjung Jabung Timur
Do Conceptions of Learning Predict Language Learning Strategies? Evidence from Indonesian EFL Learners
Authors: Kamil Dairabi 
Published: February 2022

Research has shown that information on students’ conceptions of learning (COL) and their language learning strategies (LLS) are beneficial for understanding certain recurring phenomena of foreign language learning and outcomes. However, these two constructs have been separately studied from each other. This study sought to fill this void by investigating the relationship between the constructs and the extent to which COL predicts LLS. Data were collected by administering the Conceptions of Learning Inventory (COLI) and Strategy Inventory for Language Learning (SILL) to 210 pre-service EFL teachers at an English department of a state higher education institution in Indonesia. Data were analyzed using the nonparametric Spearma’s-Rho test and Regression Tree (RT) analysis technique. The results show statistically significant positive correlations between the two constructs. Further analyses show that COL, to some extent, predicted LLS.
Liquid Metal Sloshing for High-load Active Self-healing System: An Application to Tendon-driven Legged Robot
Authors: Nakashima Shinsuke , Kawaharazuka Kento , Nagamatsu Yuya , Shinjo Koki , Miki Akihiro , Suzuki Temma , Asano Yuki , Kakiuchi Yohei , Okada Kei , Inaba Masayuki , Pepe Alberto 
Published: February 2022

This Supporting information includes supporting fugures and videos for
our paper. The information’s Fig. 16 is the high-quality version of the
article’s Supplementary Movie 1.
Corresponding author(s) Email:
nakashima@robot.t.u-tokyo.ac.jp
Thoracoscopic management of iatrogenic cardiac perforations
Authors: Langenaeken T. , Berg M. Van den , Kaya A. , Yilmaz A. 
Published: February 2022

Aims: Iatrogenic cardiac perforation is an uncommon but
potentially fatal complication of invasive cardiac procedures. When
non-surgical management fails, urgent cardiac surgery is required.
Standard surgical approach is usually through full sternotomy. However,
we propose a less invasive and equally effective technique with
video-assisted thoracoscopic surgery (VATS). Methods: This
single-center retrospective study in a tertiary hospital identified all
patients requiring surgical intervention due to iatrogenic cardiac
perforation over a period of 5 years. Patients were grouped by surgical
approach, being either sternotomy or VATS. Primary endpoints were length
of ICU stay, hospital stay, 30-day mortality and all round mortality.
Results: 25 patients were identified: 11 in the
sternotomy-group and 14 in the VATS-group. Preoperative baseline
characteristics were equal. Significant difference was found for 30-day
mortality (p < 0.05). There was no difference for the other
endpoints. Conclusions: Video-assisted thoracoscopic surgery is
a promising alternative to standard sternotomy for iatrogenic cardiac
perforations after invasive cardiac procedures.
Torque control of maxillary anterior teeth with the double J retractor and palatal miniscrews during en masse retraction:
Authors: Liaw Johnny , Huang Greg , Tsai Fang-Fang , Wang Shin-Huei , Liao Wendy 
Published: February 2022

ABSTRACT
A double J retractor (DJR) and palatal miniscrews were used to retract maxillary anterior teeth after failure of buccal posterior miniscrews. The line of action passing through the center of resistance of the maxillary anterior teeth and the moment generated by the palatal miniscrews via torquing springs successfully controlled the overbite and incisor torque during space closure. The DJR and palatal miniscrews work well with labial fixed appliances to address bimaxillary protrusion.
Influence of personality traits on a patient's decision to accept orthognathic surgery for correction of dentofacial deformity
Authors: Vidakovic Renata , Zigante Martina , Perkovic Vjera , Spalj Stjepan 
Published: February 2022

ABSTRACT

Objectives
To investigate the influence of personality traits in addition to quality of life (QoL) on the decision to accept orthognathic surgery.

Materials and Methods
A total of 108 patients (68% female) aged 14–53 years (median, 18 years; interquartile range, 17–25.75 years), with skeletal malocclusions of Index of Orthognathic Functional Treatment Need grades 3–5 (moderate to very great need for surgery) were included in this cross-sectional study. Personality traits of extraversion, neuroticism, agreeableness, openness, consciousness, perfectionism, and self-esteem and dimensions of Orthognathic Quality of Life Questionnaire were compared between patients who accepted orthodontic preparation for orthognathic surgery and those who refused (n = 55 vs 53).

Results
Patients who accepted the suggested surgical procedure had higher age, perfectionism, facial esthetic (FE) concern, social aspect, and impairment of oral function (OF) as well as lower self-esteem with small to medium effect sizes (P ≤ .040; r = 0.198–0.399). Other personality traits and awareness of dentofacial deformity did not differ between the groups. In multiple logistic regression analysis, while controlling for sex, perfectionism, and self-esteem, the following predictors of acceptance of orthognathic surgery were higher: FE concern (odds ratio [OR], 3.4; 95% confidence interval [CI], 1.3–9.1), OF (OR, 3.0; 95% CI, 1.0–8.6), and age ≥18 years (OR, 2.7; 95% CI, 1.0–7.1; P &lt; .001).

Conclusions
Extraversion, neuroticism, agreeableness, conscientiousness, and openness do not significantly affect a patient's decision to accept orthognathic surgery. The influence of self-esteem and perfectionism is primarily on perception of alteration of QoL induced by dentofacial deformity.
Dashboard Monitoring Atmospheric Corrosion Sensor in Material Metal Using Laravel Framework
Authors: Rohmalia Nima , Nama Gigih Forda , Purwasih Nining 
Published: February 2022

Corrosion is a chemical reaction that occurs in materials made of iron such as steel. Steel that is experiencing corrosion will appear dark brown spots, the longer it is getting more and more and can cover the entire surface. Corroded steel will result in a major deterioration and structural failure because the thickness of the steel will decrease over a period of time, so the safety of the building is clearly not guaranteed[1]. Research on the tools used to detect the corrosion value of steel has been carried out. However, not using the internet of things technology. Therefore, a web-based corrosion monitoring or monitoring system was designed. The web will display data on voltage and temperature values ??in the form of numbers and charts. In addition, the website can also send SMS and Whatsapp message notifications if the value obtained exceeds the threshold. In developing this website using the prototype method, Laravel Framework, PHP and Java programming languages, MySQL database, Guzzle, and Whatspie as automatic message sending bots. System can provide information of monitoring regarding dummy, active and delta voltage along with their time and temperature.
Frequency Stability Control In Low -Inertia Power System Using Virtual Synchronous Generator
Authors: Putri Novia Utami Putri , Khairudin Khairudin , Purwasih Nining 
Published: February 2022

The stability of the electric power system is divided into transient stability, steady state stability and dynamic stability. Things that affect the performance of the generator include the addition of generators, changes in the load that vary in the system which have an impact on system stability and the distance between the generator and the load. The addition of a Virtual Synchronous Generator (VSG) is needed to improve the power system that is integrated with Renewable Energy Systems Source in maintaining system stability. When the integration between conventional generators and Renewable Energy Systems Source without Virtual Synchronous Generator (VSG) has a frequency response of 58.2 Hz when the generating capacity is -40% of the initial state, while integration between conventional generators and Renewable Energy Systems Source with Virtual Synchronous Generator (VSG) has a steady state response of 60 Hz even though the generating condition is 40% of the initial capacity of the generator. This means that the Virtual Synchronous Generator (VSG) can stabilize the return frequency in its nominal value on the system.
Keywords : Inertia, Conventional Generating, Renewable Energy Systems Source, Virtual Synchronous Generator (VSG).