bluuebunny/crossref_metadata_2025_split huggingface dataset:
Conservantes farmacotécnicos utilizados em produtos dermocosméticos magistrais.
Authors: Alves Galo Amanda , Yoshie Outa Camila , Ribeiro dos Santos Lidiane , Silveira Bertoluci Raquel , Silveira Barsotti Nathália 
Published: May 2022

Com o histórico da cultura da beleza desde os primórdios, os cosméticos estão sempre presentes na vida do ser humano e, com o passar do tempo, surgiram os famosos dermocosméticos, que se diferenciam por possuírem ativos farmacológicos em sua composição, agindo assim não só na parte estética, mas promovendo saúde e bem-estar ao consumidor. Com todo esse avanço, cada vez mais as empresas desse ramo se especializam e aprimoram seus produtos, buscando oferecer ao consumidor uma formulação estável, segura e eficaz.
Para garantir uma maior segurança e estabilidade da formulação a ser preparada, é de suma importância que agentes microbianos não consigam proliferar no produto, e para isso são adicionados agentes conservantes, podendo ser de origem natural ou sintética.
O presente trabalho busca, através de revisão bibliográfica, apresentar as principais características desses agentes mais referenciados na literatura pesquisada para formulações dermocosméticas, seus benefícios e possíveis malefícios, colaborando assim, com o discernimento quanto a melhor escolha para uma determinada formulação.
Serão abordados os seguintes agentes conservantes: Ácido Benzoico, um dos primeiros aprovados pelo FDA; Ácido Sórbico, podendo ser de origem natural; Fenoxietanol, que pode ser derivado do chá verde ou sintetizado em laboratório; os famosos Parabenos, conservantes utilizados em larga escala no mercado; e Triclosan, agente muito utilizado em diversos produtos de cuidados pessoais, como desodorantes.
MASTERING METHODOLOGICAL TECHNIQUES ORGANIZATIONS OF JOINT EDUCATIONAL ACTIVITIES STUDENTS - ONE OF THE AREAS OF PROFESSIONAL PREPARATIONS FOR FUTURE MUSIC TEACHERS
Authors: Borysenko T.H. 
Published: May 2022

The traditional and other methodical techniques of effective nitftini. iifmn of educational activities of pupils at the music lesson at school, analyzed in the article. Gaining the experience of using these twchniques improves the professional Teachers Training activities of the future specialists.
Reducción del subsidio a los combustibles y su incidencia en las ventas caso: gasolinera Garages Standard
Authors: Zambrano-Zambrano Yosselyn , Toala-Mendoza Susy 
Published: May 2022

Los subsidios en el mundo son utilizados como una herramienta oportuna para el desarrollo social y económico de la sociedad. Sin embargo un subsidio sin objetivo focal puede distorsionar su efecto.
El Ecuador brinda diversos subsidios para su población y entre ellos está el de los combustibles, el cual le cambio la figura al estado de ser un exportador de petróleo a un importador de derivados para satisfacer su demanda interna.
A lo largo de la historia del país el tema del subsidio a los combustibles se convirtió en una estrategia de orden político, la misma que al querer ser eliminada por el grado de recursos que se utilizan para su ejecución, ha generado conmoción social, político y desequilibrio económico.
Es por esto que el objetivo de esta investigación fue determinar la incidencia en las ventas de la gasolinera Garages Standard por la reducción del subsidio a los combustibles, mediante la evaluación de los estados de resultados y el arqueo de ventas por producto, quienes son la fuente primordial de información financiera de la empresa. El método de investigación fue de orden cuantitativo basado en análisis bibliográfico y estudio de campo, corroborando las referencias obtenidas mediante las fuentes de información. Dentro de los resultados obtenidos se determinó que la reducción del subsidio al combustible incidió de manera desfavorable en las ventas de la gasolinera, quien se vio en la necesidad de recurrir a la venta de sus activos para enfrentar los problemas de liquidez ocasionados por la misma.
Clinical opportunities and healthcare impact of optimal treatment in the post-ACS patient
Authors: Gargiulo Giuseppe , Esposito Giovanni 
Published: May 2022

Despite the improvement of revascularization procedures, patients with acute coronary syndrome often develop recurrent ischemic events, suggesting a high residual cardiovascular risk in these patients, which requires a strict clinical monitoring as well as an optimal control of modifiable risk factors. To this aim, an optimal management of index event and appropriate preventive measures are equally important. Hospital care by cardiologists should be followed by outpatient management by general practitioners, as established by specific diagnostic and therapeutic pathways, which should warrant an optimal support to the patient. A strict collaboration between hospital and primary care is crucial to monitor and adapt drug therapy after the acute event and improve adherence of the patients to prescribed treatments and implementation of life-style modifications, with benefits also in term of cost-effectiveness. In this context, individualized rehabilitation programs should also be offered to patients with acute coronary syndromes, in order to improve survival and quality of life.
Sistem Pewarisan Hukum Adat Suku Moi Di Kota Sorong
Authors: Markus Dwi Pratiwi , Mahmudah Masrifatun , Islamiaty Nurul 
Published: May 2022

Customary law is one of the laws that is still firmly enforced in Sorong City, West Papua, the Moi Tribe is one of several tribes in Sorong City and is a tribe that is still thick in the customary law inheritance system. The position of sons and daughters in the customary law inheritance system of the Moi tribe is often a matter of debate, because looking at the customary law system that applies in Papua, it still uses the Patriarchal system but is also based on family law.Â Â Â Â Â Â Â Â Â Â Â This research is empirical research, namely legal research by using field data as primary data sources, such as the results of interviews, observations and documentation. Then it is supported by secondary data, namely articles, journals and previous research.Â Â Â Â Â Â Â Â Â Â Â The results of this study indicate that: 1). The Customary Inheritance System in the MOI Tribe gives equal status to men and women as heirs, but there are differences in the distribution of inheritance. 2). The difference in the position of female heirs and male heirs is caused by the MOI Indigenous Community adhering to the principle of patriarchy, namely, men are the first heirs and women are the second heirs.
Pengembangan Dan Analisis Black Box Hutan Sagu Alam (Hsa) Di Kabupaten Sorong Selatan (Studi Kasus Di Kampung Puragi Dan Bidare Distrik Matemani)
Authors: Maruapey Azis 
Published: May 2022

Permasalahan utama pengembangan Hutan Sagu Alam (HSA) di Kampung Puragi dan Bedare Distrik Metemani Kabupaten Sorong Selatan terutama disebabkan: pertama, pengolahan masih bersifat tradisional; kedua, pemasaran pati sagu yang masih terbatas; dan ketiga, mutu pati sagu masih rendah. Tujuan riset ini adalah mengetahui prospek pengembangan hutan sagu alam di Kampung Puragi dan Bedare; mengetahui strategi pengembangan potensi hutan sagu alamnya; dan mengetahui model analisis Black Box untuk pengembangan hutan sagu alamnya. Metode yang digunakan adalah metode survey langsung dan wawancara FGD dengan masyarakat. Hasil penelitian terlihat bahwa prospek pengembangan Sagu di Kampung Puragi dan Bedare meliputi a) sagu sebagai bahan pangan, dengan potensi hutan sagu alam yang besar, diyakini pati sagu akan menjadi Â sumber makanan pengganti beras, dan berbagai industri; dan b) sagu sebagai konservasi air dan perlindungan lingkungan iklim makro guna mengurangi emisi gas rumah kaca. Strategi pengembangan hutan sagu alam yakni:1) Pemberdayaan sumber daya manusia lokal dan kelembagaannya; 2) Penataan hutan sagu guna meningkatkan produktivitas per satuan area; 3). Menyediakan infrastruktur pengolahan sagu berbasis masyarakat; 4) Perencanaan air bersih untuk pengolahan sagu; 5) Menumbuhkembangkan pola kemitraan dan home industry;6) Penguatan kelembagaan usaha; dan 7) Dukungan kebijakan pemerintah daerah. Model black box pengembangan Hutan Sagu Alam terintegrasi melalui faktor dukungan input lingkungan dengan parameter rancang bangunnya yakni luas hutan sagu alam beserta potensinya yang besar dan kelembagaan masyarakat pemegang hak ulayat. Model pengembangan ini dipengaruhi oleh faktor input (terkontrol dan tidak terkontrol) dan output (yang diinginkan dan tidak diinginkan).
Phenology of Cinnamomum cullilawan
Authors: Siburian Rima Herlina 
Published: May 2022

Abstract Cinnamomum cullilawan is one type of forest plants that is included in the type of aromatic plants. The purpose of this study was to determine the flowering development process as a basicÂ information for the development and the breeding of this plant. The method used in this research was a descriptive method. The results of the observations indicated that the process of flowering C. cullilawan can be grouped into three major parts: the stage of initiation, budding and flowering, where each stage requires different formation times. At the initiation stage, since the emergence of generative shoots on the armpit until the formation of panicles takes two months. Furthermore, the stage of the appearance of buds at the ends of panicles and the formation of reproduction of flowers required two months period. After that the flowers will break slightly and then the petals will turn black and fall in the second week, after the flower process has blossomed.
Pengembangan Usaha Nasi Kuning di Harapan Indah Kelurahan Klawuyuk Distrik Sorong Barat
Authors: Sofia Susetyowati , Wangsi Mitta Muthia 
Published: May 2022

Kegiatan ini ditujukan untuk memberikan pelatihan dalam berwirausaha khususnya dalam menggunakan kesempatan mengembangkan kemampuan yang dimiliki untuk membaca peluang berbisnis. Kegiatan pelatihan bertempat di komplek harapan indah kelurahan klawuyuk distrik sorong barat. Dalam pendekatannya penelitian ini menggunakan pendekatan kualitatif. Dan hasil yang diperoleh dari kegiatan pelatihan ini menunjukan adanya pengembangan sikap berbisnis usaha nasi kuning ibu-ibu komplek harapan indah yang ditunjukan dalam hal kreatifitas menghias tampilan hidangan (platting) nasi kuning menjadi lebih menarik dan jugaÂ inovatif dalam mengembangkan produk nasi kuning yang awalnya monoton dibungkus ditambah menjadi bentuk tumpeng besar dan tumpeng mini. Selain itu juga mereka mampu menerapkan strategi pemasaran dengan cara memberikan varian lauk pauk yang lebih variatif kepada konsumennya. Diiringi sikap semangat, optimis dan konsisten dalam berwirausaha diharapkan ibu-ibu komplek harapan indah mampu mempertahan bisnis usaha nasi kuning.
Kanal Televisi Pada Media Sosial untuk Promosi di Kampoeng Wisata Titik Nol Jateng
Authors: Lephen Purwanto , Kumoro Risang Panji , Prajahita Putri Sima 
Published: May 2022

Desa Wisata â€œKampoeng Wisata Titik Nol Jatengâ€ berada di perbatasan Jateng dan DIY. Sebagaian besar warga di Desa Bligo, Nguwar, Kabupaten Magelang, Jawa Tengah memiliki smartphone dengan spesifikai yang canggih dan dapat memutar serta membuat multi media. Ada 20 anak dan remaja yang berminat menggunakan smatphone membuat konten berita dan reportase kegiatan di Kampoeng Wisata Titik Nol Jateng. Kunjungan pewisata ke destinasi tersebut kemudian dilfoto, divideo, diiput dan diunggah ke media sosial. Guna memberdayakan potensi para yutuber muda di Kampoeng Wisata Titik Nol Jateng, diselenggarakan pelatihan mengambil gambar, penyuntingan, reporter, dan membuat kanal berita Titik Nol TV. Jumlah peserta yang terampil bermedia sosial dan memuat di kanal Titik Nol TV di Blaburan semakin meningkat secara kualitas dan kuantitas. Namun, perlu ditingkatkan dengan memasang hotspot yang lebih baik dan peralatan produksi yang lebih berkualitas agar potensi yutuber di daerah tersebut semakin bermanfaat bagi pengembangan desa wisata berkelanjutan, Â mensejarahterakan Â warga setempat.
Peran Dan Partisipasi Masyarakat Dalam Pembangunan Air Bersihm(Kolaborasi Masyarakat Kampung dengan Mahasiswa PHP2D Universitas Muhammadiyah Sorong)
Authors: Basri La , Mardliyah Uswatul , Rumalean Jufri , Kalagison Miryam Diana , Abdullah Abdullah 
Published: May 2022

Air merupakan salah satu faktor terpenting masih manusi dalam menjalankan aktifitas keseharianya, sehingga perlu adanya peran dan partisipasi masyarakat dalam memenuhi Â kebutuhan hitup tersebut. Metode kualitatif yang digunakan dalam pengabdian ini, yang meliputi pekerjaan secara penuh di lapangan selama satu minggu di kampung Baingkete dengan langkah; 1) Persiapan (survey lokasi, wawancara, pemetaan lokasi dan sosialisasi; 2) Pelaksanaan ProgramÂ (program air bersih) dan; 3) Evaluasi Program (tindahlanjut program). Program ini menitiberatkan pada 25 kepala keluarga yang belum menikmai air bersih secara baik dari jumlah 43 kepala keluarga yang ada di kampung Baingkete. Peran dan partisipasi masyarakat sangat baik dan menunjukan rasa kepedulian kepada tim pengabdian dengan adanya rasa kekerabatan yang terbangan antara mahasiswa dan masyarakat setempat.
Synoviocyte-Derived Extracellular Matrix and bFGF Speed Human Chondrocyte Proliferation While Maintaining Differentiation Potential
Authors: Truong Rachel D. , Bernier Megan A. , Dennis James E. , Kean Thomas J. 
Published: May 2022

Improving the ability of human chondrocytes to proliferate, while maintaining their differentiation potential, has presented a great challenge in cartilage tissue engineering. In this study, human chondrocytes were cultured under four unique growth conditions at physiologic oxygen tension: tissue culture plastic (TCP) only, synoviocyte matrix (SCM)–coated flasks only, SCM-coated flasks with bFGF media supplement, and TCP with bFGF media supplement. The results indicated that, compared to standard TCP, all test conditions showed significantly increased cell expansion rates and an increase in both glycosaminoglycan (GAG) and collagen content during redifferentiation culture. Specifically, the combined SCM + bFGF growth condition showed an additive effect, with an increase of approximately 36% more cells per passage (5–7 days) when compared to the SCM alone. In conclusion, the results of this study demonstrate that bFGF and SCM can be used as supplements to enhance the growth of human chondrocytes both as individual enhancers and as a combined additive.
Transcriptional Effects of Candidate COVID-19 Treatments on Cardiac Myocytes
Authors: Jakobi Tobias , Groß Julia , Cyganek Lukas , Doroudgar Shirin 
Published: May 2022

IntroductionSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) disease (COVID-19) has emerged as a major cause of morbidity and mortality worldwide, placing unprecedented pressure on healthcare. Cardiomyopathy is described in patients with severe COVID-19 and increasing evidence suggests that cardiovascular involvement portends a high mortality. To facilitate fast development of antiviral interventions, drugs initially developed to treat other diseases are currently being repurposed as COVID-19 treatments. While it has been shown that SARS-CoV-2 invades cells through the angiotensin-converting enzyme 2 receptor (ACE2), the effect of drugs currently repurposed to treat COVID-19 on the heart requires further investigation.MethodsHuman induced pluripotent stem cell-derived cardiac myocytes (hiPSC-CMs) were treated with five repurposed drugs (remdesivir, lopinavir/ritonavir, lopinavir/ritonavir/interferon beta (INF-β), hydroxychloroquine, and chloroquine) and compared with DMSO controls. Transcriptional profiling was performed to identify global changes in gene expression programs.ResultsRNA sequencing of hiPSC-CMs revealed significant changes in gene programs related to calcium handling and the endoplasmic reticulum stress response, most prominently for lopinavir/ritonavir and lopinavir/ritonavir/interferon-beta. The results of the differential gene expression analysis are available for interactive access at https://covid19drugs.jakobilab.org.ConclusionTranscriptional profiling in hiPSC-CMs treated with COVID-19 drugs identified unfavorable changes with lopinavir/ritonavir and lopinavir/ritonavir/INF-β in key cardiac gene programs that may negatively affect heart function.
The Ratio of Red Blood Cell Distribution Width to Albumin Is Correlated With All-Cause Mortality of Patients After Percutaneous Coronary Intervention – A Retrospective Cohort Study
Authors: Weng Yingbei , Peng Yangpei , Xu Yuxuan , Wang Lei , Wu Bosen , Xiang Huaqiang , Ji Kangting , Guan Xueqiang 
Published: May 2022

ObjectivesThe purpose of this study was to investigate the independent effect of the ratio of red blood cell distribution width (RDW) to albumin (RA) on all-cause mortality in patients after percutaneous coronary intervention (PCI).MethodsClinical data were obtained from the Multiparameter Intelligent Monitoring in Intensive Care-III (MIMIC-III) database version 1.4 and the database of Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University. We used the MIMIC-III database for model training, and data collected from the Second Affiliated Hospital of Wenzhou Medical University for validation. The primary outcome of our study was 90-day mortality. Cox proportional hazards regression model was used to estimate hazard ratio (HR) for the association between RA and all-cause mortality in patients after PCI. Pearson correlation analysis was conducted to assess the relationship between RA and Gensini score or cardiac troponin I (cTnI).ResultsA total of 707 patients were eligible in MIMIC-III database, including 432 males, with a mean age of 70.29 years. For 90-day all-cause mortality, in the adjusted multivariable model, the adjusted HRs [95% confidence intervals (CIs)] for the second (RA: 3.7–4.5 ml/g) and third (RA &gt;4.5 ml/g) tertiles were 2.27 (1.11, 4.64) and 3.67 (1.82, 7.40), respectively, compared to the reference group (RA &lt;3.7 ml/g) (p &lt; 0.05). A similar relationship was also observed for 30-day all-cause mortality and 1-year all-cause mortality. No significant interaction was observed in subgroup analysis. Receiver operating characteristic (ROC) curve analysis proved that the ability of RA to predict the 90-day mortality was better than that of RDW or albumin alone. The correlation coefficient between Gensini score and RA was 0.254, and that between cTnI and RA was 0.323.ConclusionRA is an independent risk factor for all-cause mortality in patients after PCI. The higher the RA, the higher the mortality. RA has a good predictive ability for all-cause mortality in patients after PCI, which is better than RDW or albumin alone. RA may be positively correlated with the severity of coronary artery disease (CAD) in patients with CAD.
Validating GAN-BioBERT: A Methodology for Assessing Reporting Trends in Clinical Trials
Authors: Myszewski Joshua J. , Klossowski Emily , Meyer Patrick , Bevil Kristin , Klesius Lisa , Schroeder Kristopher M. 
Published: May 2022

BackgroundThe aim of this study was to validate a three-class sentiment classification model for clinical trial abstracts combining adversarial learning and the BioBERT language processing model as a tool to assess trends in biomedical literature in a clearly reproducible manner. We then assessed the model's performance for this application and compared it to previous models used for this task.MethodsUsing 108 expert-annotated clinical trial abstracts and 2,000 unlabeled abstracts this study develops a three-class sentiment classification algorithm for clinical trial abstracts. The model uses a semi-supervised model based on the Bidirectional Encoder Representation from Transformers (BERT) model, a much more advanced and accurate method compared to previously used models based upon traditional machine learning methods. The prediction performance was compared to those previous studies.ResultsThe algorithm was found to have a classification accuracy of 91.3%, with a macro F1-Score of 0.92, significantly outperforming previous studies used to classify sentiment in clinical trial literature, while also making the sentiment classification finer grained with greater reproducibility.ConclusionWe demonstrate an easily applied sentiment classification model for clinical trial abstracts that significantly outperforms previous models with greater reproducibility and applicability to large-scale study of reporting trends.
Contrasting Along-Slope vs. Downslope Sedimentation Style on the High-Latitude Eastern Canadian Continental Margin During the Last 40 ka
Authors: Rashid Harunur , He Jianing , Patro Ranjan , Brown A. Owen 
Published: May 2022

Late Pleistocene Labrador Sea depositional systems developed in front of ice streams and glacier outlets from the Laurentide Ice Sheet (LIS) are documented by Huntec and 3.5 kHz seismic profiles and piston cores. Due to efficient grinding by the LIS, massive amounts of fine-grained sediments and meltwater in addition to the icebergs linked to the Heinrich events (H events) of the last glaciation were delivered to the neighboring Labrador Sea. The position of the Hudson Strait ice stream during the periodic expansion and contraction on the Labrador margin allowed fine-grained sediments and meltwater direct delivery on the lower shelf and upper slope. These discharges were then transported southward by the Labrador Current and western boundary current. In contrast to the lower shelf and upper slope, sediments delivered on the mid to the lower Labrador Slope were transported by the Northwest Atlantic Mid-Ocean Channel to distal sites. The nepheloid flow layer at or near the sea bottom or at mid-water depths developed from meltwater loaded with an excessive charge of fine-grained sediments. Contrastingly, the non-discriminatory ice rafting process delivered detritus of all sizes, but its total contribution to the sediment column was only minor, notwithstanding its paleoclimatic significance during H events. Heinrich H1, H2, and H4 layers were identified by their characteristic nepheloid flow layer deposits, that is, alternating coarse silt and clay-sized laminae with thin ice-rafted debris interspersed by coarse- to fine-grained dropstone. Furthermore, the progressive thinning and eventual disappearance of the fine-laminae (i.e., coarse and fine silt/clay) in H layers at the distal sites suggest the exhaustion and raining out of fines due to long-distance transport. However, the H3 layer was identified by a combination of nepheloid flow layer deposits (upper slope) and finely laminated mud turbidites (lower slope and deep basin) at proximal sites. In the lower Labrador Slope and Basin, the H3 stratigraphic equivalent layer was identified by exorbitantly thick finely laminated carbonate-rich mud turbidites. The divergent sedimentation style (i.e., reflected by the sediment facies) and the thickness of the H3 layer compared to other H events suggest that the Hudson Strait ice stream position was different from other H events. Therefore, our data imply that the divergence in the H3 layer between the eastern and western North Atlantic might lie with the position of the Hudson Strait ice stream on the Labrador continental margin.