bluuebunny/crossref_metadata_2025_split huggingface dataset:
Production of MHCII‐expressing classical monocytes increases during aging in mice and humans
Authors: Barman Pijus K. , Shin Juliana E. , Lewis Sloan A. , Kang Seokjo , Wu Di , Wang Yizhou , Yang Xiaoming , Nagarkatti Prakash S. , Nagarkatti Mitzi , Messaoudi Ilhem , Benayoun Bérénice A. , Goodridge Helen S. 
Published: August 2022

AbstractAging is associated with increased monocyte production and altered monocyte function. Classical monocytes are heterogenous and a shift in their subset composition may underlie some of their apparent functional changes during aging. We have previously shown that mouse granulocyte‐monocyte progenitors (GMPs) produce “neutrophil‐like” monocytes (NeuMo), whereas monocyte‐dendritic cell progenitors (MDPs) produce monocyte‐derived dendritic cell (moDC)‐producing monocytes (DCMo). Here, we demonstrate that classical monocytes from the bone marrow of old male and female mice have higher expression of DCMo signature genes (H2‐Aa, H2‐Ab1, H2‐Eb1, Cd74), and that more classical monocytes express MHCII and CD74 protein. Moreover, we show that bone marrow MDPs and classical monocytes from old mice yield more moDC. We also demonstrate higher expression of Aw112010 in old monocytes and that Aw112010 lncRNA activity regulates MHCII induction in macrophages, which suggests that elevated Aw112010 levels may underlie increased MHCII expression during monocyte aging. Finally, we show that classical monocyte expression of MHCII is also elevated during healthy aging in humans. Thus, aging‐associated changes in monocyte production may underlie altered monocyte function and have implications for aging‐associated disorders.
Multimodal archives of transborder belonging: Murals, social media, and racialized geographies in Los Angeles
Authors: Magaña Maurice Rafael 
Published: August 2022

AbstractIndigenous migrants from Latin America make up an increasing portion of the Latinx population in the United States, including in urban settings. Despite the significant ways that anti‐Indigenous racism impacts them, their narratives, experiences, and identities are often erased or collapsed into those of their non‐Indigenous compatriots in mainstream accounts of migration and of Latinx identity and belonging in the United States. This article analyzes murals by Indigenous artists from the Mexican state of Oaxaca that were painted in Los Angeles neighborhoods where members of the diaspora live as one way that these communities are making themselves visible. By framing murals and their circulation on social media as multimodal archives, I argue that young people engage in the ethnographic‐archival work of telling the stories and revealing the racialized geographies made imperceptible through city planning, mainstream media, and official archives. Ethnographic attention to the material, visual, and online archival practices of diasporic young people reveals dynamics of transnational community formation, flows of labor, place‐making, and identity‐making that are obscured when we privilege macro‐level analyses of migration, infrastructure, and markets.
Compatibility and stability of an admixture of multiple anaesthetic drugs for opioid‐free anaesthesia
Authors: Carpenter A. M. , Rodseth R. N. , Coetzee E. , Roodt F. , Bye S. 
Published: August 2022

SummaryThe ability to combine and use drugs in a single infusion device may be useful in resource‐limited settings. This study examined the chemical stability of an opioid‐sparing mixture of ketamine, lidocaine and magnesium sulphate when combined in a single syringe. High‐performance liquid chromatography and atomic absorption spectrophotometry were performed on six syringes containing the three‐drug mixture. Since most opioid‐sparing techniques typically rely on a 24‐hour infusion regime, we tested stability at the initial admixing and 24 hours later. Stability was defined as a measured drug concentration within 10% of expected, with the absence of precipitation or pH alterations. Pharmacokinetic simulations were conducted to further show that the achieved plasma drug concentrations were well within an effective analgesic range. All mixed drug concentration measurements were within the required 10% reference limit. No obvious precipitation or interaction occurred, and pH remained stable. Drug stability was maintained for 24 hours. Pharmacokinetic simulations showed that ketamine and lidocaine were within their minimum analgesic effect concentrations. Our results show that this three‐drug mixture is chemically stable for up to 24 hours after mixing, with a pharmacokinetic simulation illustrating safe, clinically useful predicted plasma concentrations when using the described admixture.
Infection calls for thrombosis: Fact or superstition?
Authors: Pektok Erman 
Published: August 2022

AbstractDespite all the efforts, pump thrombosis and thromboembolic complications still remain among the most dreadful complications after long‐term ventricular assist device implantation. There is growing evidence that infections, especially blood stream infections predispose to a prothrombotic state despite anticoagulation, and frequently leads to thrombosis and/or embolic events as a consequence. In this short comment, the article by Bouzas et al with heterodox, if not unsettling, conclusions is discussed.
Biokinetics and dosimetry of 18F‐PSMA‐1007 in patients with prostate cancer
Authors: Hvittfeldt Erland , Bjöersdorff Mimmi , Brolin Gustav , Minarik David , Svegborn Sigrid L. , Oddstig Jenny , Trägårdh Elin 
Published: August 2022

AbstractPurposePositron emission tomography‐computed tomography (PET‐CT) using prostate‐specific membrane antigen (PSMA) ligands is a method for imaging prostate cancer. A recent tracer, 18F‐PSMA‐1007, offers advantages concerning production and biokinetics compared to the standard tracer (68Ga‐PSMA‐11). Until now, radiation dosimetry data for this ligand was limited to the material of three healthy volunteers. The purpose of this study is to study the biokinetics and dosimetry of 18F‐PSMA‐1007.MethodsTwelve patients with prostate cancer were injected with 4 MBq/kg 18F‐PSMA‐1007. Eight PET‐CT scans with concomitant blood sampling were performed up to 330 min after injection. Urine was collected until the following morning. Volumes of interest for radiation‐sensitive organs and organs with high uptake of 18F‐PSMA‐1007 were drawn in the PET images. A biokinetic compartment model was developed using activity data from PET images and blood and urine samples. Time‐activity curves and time‐integrated activity coefficients for all delineated organs were calculated. The software IDAC‐dose 2.1 was used to calculate the absorbed and effective doses.ResultsHigh concentrations of activity were noted in the liver, kidneys, parts of the small intestine, spleen, salivary glands, and lacrimal glands. The elimination through urine was 8% of injected activity in 20 h. The highest absorbed doses coefficients were in the lacrimal glands, kidneys, salivary glands, liver, and spleen (98–66 µGy/MBq). The effective dose coefficient was 25 µSv/MBq.ConclusionThe effective dose of 18F‐PSMA‐1007 is 6.0–8.0 mSv for a typical patient weighing 80 kg injected with 3–4 MBq/kg.
Variation in contact chemical cues may mediate differential predator response in the colour polymorphic tortoise beetle,Chelymorpha alternans
Authors: Strickland Lynette R. , Windsor Donald , Cáceres Carla E. 
Published: August 2022

AbstractDifferential predation on species with intraspecific colour variation has been explored in various systems and is often implicated as the driving force behind colour polymorphism maintenance.Here, investigation done on whether predation contributes to the maintenance of extensive colour variation in the Neotropical tortoise beetle,Chelymorpha alternans(Chrysomelidae). Recorded predation rates on different colour pattern phenotypes by three common, generalist invertebrate predators, and identified potential chemical signals of unpalatability.Predaceious mantids (Orthoptera, Mantidae) consumed no beetles, regardless of phenotype, whereas the giant orb‐weaving spider (Trichonephila clavipes; Araneidae) consumed all three beetle phenotypes. The carton‐nest ant,Azteca chartifex(Formicidae), displayed differential predation; the rufipennis phenotype ofC. alternanswas sometimes consumed, the metallic phenotype was never consumed, and the veraguensis phenotype was consumed in the first three encounters and subsequently discarded, suggesting a learned avoidance behaviour.Using gas chromatography–mass spectrometry, it was determined that cuticular hydrocarbon profiles were similar between the metallic and militaris‐a phenotypes. The rufipennis phenotype showed pronounced differences and displayed the greatest among‐individual variation in elytral cuticular profiles.Between‐phenotype variation in chemical cues, and differences in how predators receive those cues, may mediate predator response, and play a role in maintaining colour variation in this species.
Diagnostic accuracy of nerve ultrasonography for the detection of peripheral neuropathy in type 2 diabetes
Authors: Dhanapalaratnam Roshan , Issar Tushar , Poynten Ann M. , Milner Kerry‐Lee , Kwai Natalie C. G. , Krishnan Arun V. 
Published: August 2022

AbstractBackground and purposeNerve conduction studies (NCS) are the current objective measure for diagnosis of peripheral neuropathy in type 2 diabetes but do not assess nerve structure. This study investigated the utility of peripheral nerve ultrasound as a marker of the presence and severity of peripheral neuropathy in type 2 diabetes.MethodsA total of 156 patients were recruited, and nerve ultrasound was undertaken on distal tibial and distal median nerves. Neuropathy severity was graded using the modified Toronto Clinical Neuropathy Scale (mTCNS) and Total Neuropathy Score (TNS). Studies were undertaken by a single ultrasonographer blinded to nerve conduction results.ResultsA stepwise increase in tibial nerve cross‐sectional area (CSA) was noted with increasing TNS grade (p < 0.001) and each mTCNS quartile (p < 0.001). Regression analysis demonstrated a correlation between tibial nerve CSA and neuropathy severity (p < 0.001). Using receiver operator curve analysis, tibial nerve CSA of >12.88 mm yielded a sensitivity of 70.5% and specificity of 85.7% for neuropathy detection. Binary logistic regression revealed that tibial nerve CSA was a predictor of abnormal sural sensory nerve action potential amplitude (odds ratio = 1.239, 95% confidence interval [CI] = 1.142–1.345) and abnormal neuropathy score (odds ratio = 1.537, 95% confidence interval [CI] = 1.286–1.838).ConclusionsTibial nerve ultrasound has good specificity and sensitivity for neuropathy diagnosis in type 2 diabetes. The study demonstrates that tibial nerve CSA correlates with neuropathy severity. Future serial studies using both ultrasound and NCS may be useful in determining whether changes in ultrasound occur prior to development of nerve conduction abnormalities and neuropathic symptoms.
The development and utility of a multicriteria patient decision aid for people contemplating treatment for osteoarthritis
Authors: Moreton Sam G. , Salkeld Glenn , Wortley Sally , Jeon Yun‐Hee , Urban Hema , Hunter David J. 
Published: August 2022

AbstractBackgroundThere are a range of treatment options for osteoarthritis (OA) of the knee and hip, each with a unique profile of risks and benefits. Patient decision aids can help incorporate patient preferences in treatment decision‐making. The aim of this study was to develop and test the utility of a patient decision aid for OA that was developed using a multicriteria decision analytic framework.MethodsPeople contemplating treatment for OA who had accessed the website myjointpain.org.au were invited to participate in the study by using the online patient decision aid. Two forms of the patient decision aid were created: A shorter form and a longer form, which allowed greater customization that was offered to respondents after they had completed the shorter form. Respondents also completed questions asking about their experience using the patient decision aid.ResultsA total of 625 self‐selected respondents completed the short‐form and 180 completed the long‐form. Across both forms, serious side effects, pain and function were rated as the most important treatment outcomes. Most respondents (64%) who completed the longer form reported that using the tool was a positive experience, 38% reported that using the tool had changed their mind and 48% said that using the tool would improve the quality of their decision‐making.ConclusionsOverall, the findings suggest that this patient decision aid may be of use to a substantial number of people in facilitating appropriate treatment decision‐making.Patient or Public ContributionService users of myjointpain.org.au were involved through their participation in the study, and their feedback will guide the development of future iterations of the tool.
Phase transformation of FeCr2O4 to (Fe,Cr)2O3 solid solution pigment powders: Effect of post‐heating temperature
Authors: Paborji Fatemeh , Shafiee Afarani Mahdi , Arabi Amir Masoud , Ghahari Mehdi 
Published: August 2022

AbstractIron chromite powders were synthesized via solution combustion route using iron(III) nitrate nonahydrate and chromium(III) nitrate nonahydrate as starting materials, as well as glycine–urea, glycine–citric acid, and glycine–ethylene glycol mixtures as fuels. The effect of postheating at different temperatures on the structure, molecular, microstructure, and chromatic properties of powders and tiles colored by in‐glaze powders was studied. The X‐ray diffraction patterns showed that as‐synthesized powders were obtained in crystalline FeCr2O4 phases moreover, postheating of the powders led to d‐space shift and oxidation and formation of (Fe,Cr)2O3 solid solution phase regardless of fuel type. Phase transformation of FeCr2O4 to (Fe,Cr)2O3 solid solution was observed at 500/750°C depending on the dominant phase of as‐synthesized particles. Fourier transform infrared analysis illustrated that the band positions of octahedral M–O and tetrahedral M–O bonds were shifted due to Fe cations movement from their position and lattice shrinkage by increasing of post‐heating temperature. Moreover, scanning electron micrographs showed that Fe0.7Cr1.3O3 semispherical fine particles were formed from porous spongy FeCr2O4 particles due to oxidation and phase transformation during the postheating. Furthermore, chromatic properties of the samples were represented. The color properties of the pigments showed that the formation of brown pigments is provided with the phase transformation from FeCr2O4 to (Fe,Cr)2O3 at a temperature of up to 750°C. Moreover, increasing the color purity to this temperature is related to the removal of residual carbonaceous matters. The chromatic properties of the glazed tiles colored using the pigments showed that postheating between 250 and 500°C led to more brown appearance.
Phase stability, mechanical, and thermal properties of high‐entropy transition and rare‐earth metal diborides from first‐principles calculations
Authors: Zhang Ze , Zhua Shizhen , Liu Yanbo , Liu Ling , Ma Zhuang 
Published: August 2022

AbstractThe narrow composition design space of high‐entropy transition metal diborides (HE TMB2) limits their further development. In this study we designed six quaternary and quinary high‐entropy transition metal and rare‐earth diborides (HE TMREB2) and investigated their phase stability using the energy distribution of the local mixing enthalpy of all possible configurations. The results show that both quaternary and quinary HE TMREB2 have higher enthalpic driving forces, which facilitates the formation of single‐phase AlB2‐type structures between TMB2 and REB2. Calculations of elastic constants show that the TMB2 component has the greatest effect on the c44 elastic constant and shear modulus G, while REB2 significantly influences the bulk modulus B. Furthermore, LuB2 and TmB2 substantially affect the elastic modulus anisotropy of HE TMB2. Rare‐earth atoms in HE TMREB2 can enhance the nonharmonic interactions between phonons, which results in a significant hindrance in the thermal transport of low‐frequency phonons as well as an increase in the volume thermal expansion coefficients. Thus, the incorporation of REB2 into HE TMB2 has a significant impact on the phase stability and properties.
Fractional microneedle radiofrequency treatment for enlarged facial pores: A real‐world retrospective observational study on 75 patients
Authors: Ren Kehui , Liu Houfang , Li Bingyan , Zhou Bingrong 
Published: August 2022

AbstractObjectiveThis study aimed to analyze the clinical results and influencing factors of the fractional microneedle radiofrequency (FMR) treatment for enlarged facial pores on different facial sites.MethodsThe clinical data of patients with enlarged facial pores who underwent FMR treatment from January 2019 to December 2020 were collected. The efficacy and complications of FMR for enlarged pores in different facial areas were retrospectively analyzed. Univariate and multivariate logistic regression analyses were used to explore the clinical factors related to the efficacy of FMR after the first treatment session.ResultsTotally, 75 patients with enlarged facial pores were included (full‐face FMR for 45, nasal FMR for 58, frontal FMR for 45, and cheek FMR for 72 patients). All patients received more than one treatment session, two patients received five treatment sessions, and the mean number of FMR session was 1.7. The moderate to excellent improvement rates in patients with nasal, frontal and cheek enlarged pores after the first session were 13.8%, 8.9%, and 11.1%, respectively. The improvement rate rose with the increasing number of treatment sessions. Multivariate logistic regression analysis revealed that long pulse‐width (300 ms) was positively associated with clinical efficacy after the first session (OR = 22.4, 95% CI [2.0–250.4], p = 0.012), compared with the short pulse‐width group (100–200 ms). The main adverse effects after FMR were transient pain, erythema, and edema. A minority of patients developed acneiform eruption.ConclusionThis study confirms that FMR is safe and effective in improving enlarged facial pores. The pulse width is associated with the improvement of nasal enlarged pores.
Longitudinal and situational associations between math anxiety and performance among early adolescents
Authors: Sorvo Riikka , Kiuru Noona , Koponen Tuire , Aro Tuija , Viholainen Helena , Ahonen Timo , Aro Mikko 
Published: August 2022

AbstractStudies have found math anxiety and achievement to be related from the beginning of formal schooling, but the knowledge regarding the direction of the relationship is vague. The purpose of the present study was to study this relationship. We investigated math anxiety from two points of view: trait and state anxiety. In the first substudy, we investigated the longitudinal relationship between math anxiety and performance from sixth to seventh grade (n = 848) with cross‐lagged modeling. In the second substudy, we investigated the situational relationship of anxiety and performance by giving the participants (n = 149) challenging and nonchallenging math tasks adapted to their skill level, and then examining the association between anxiety and the performance. The results suggest that math anxiety has a small longitudinal effect on performance: High anxiety in sixth grade predicted low performance in seventh grade. Anxiety also had a situational association with performance: when anxiety was aroused, the participants performed more poorly compared to their skill level. The results adduce the two‐fold effect of anxiety on achievement: math anxiety seems to have both a real‐time association with performance and a long‐term effect on the development of basic arithmetic skills.
Nonuniform laminated beam of Lord–Shulman type
Authors: Feng Baowei , Cabanillas Victor R. , Coayla‐Teran Edson A. , Raposo Carlos A. 
Published: August 2022

AbstractThe nonuniform thermoelastic laminated beam of the Lord–Shulman type is considered. The model is a two‐layered beam with structural damping due to the interfacial slip. The well‐posedness is proved by the semigroup theory of linear operators approach together with the Lumer–Phillips theorem. The stability results presented in this paper depend on the nature of a stability function , which we define in (12). We first prove the lack of exponential stability of the system if , . And then, we establish the exponential stability for and polynomial decay with rate provided , . The result is new, and it is the first time that the nonuniform laminated beam is considered.
Long gun suicides in the state of Maryland following the firearm safety act of 2013
Authors: Pan Isabella , Zinko James , Weedn Victor , Nestadt Paul S. 
Published: August 2022

AbstractObjectivesIn 2013, the state of Maryland passed the Firearms Safety Act limiting the private sales of handguns, which did not apply to long guns often used for hunting (e.g., rifles and shotguns). This decreased the accessibility of handguns relative to long guns. We assessed the frequency of long gun suicides in the years before and after the policy change during winter season, which encompasses hunting season in Maryland.MethodsWe performed a retrospective analysis on all 4107 well‐characterized adult suicides caused by firearms in Maryland from 2003 through 2019. Logistic regression was performed, stratifying by decedent sex, race, and age.ResultsWhile handgun suicides decreased in the period after 2013's Firearm Safety Act (p < 0.008), wintertime long gun suicides increased after 2013 (p < 0.004). Caucasian race (p < 0.006), male sex (p < 0.005), and middle age (p < 0.001) were significantly associated with wintertime long gun suicides after 2013.ConclusionOur findings suggest that while the 2013 Firearms Safety Act decreased handgun suicides significantly, it did not reduce long gun suicides and there may even have been replacement with long guns during hunting season, when rifles are out and accessible. This association was most prominent among the demographics most likely to hunt (Caucasian, middle‐aged, and male).
Exposure to FDI and attitudes towards multinational enterprises: Do M&A matter?
Authors: Franco Chiara , Marin Giovanni , Pietrovito Filomena 
Published: August 2022

AbstractThis study aims to investigate the role of multinational enterprises' (MNE) penetration at the occupation‐country level to form individuals' preferences towards MNE. We combine individuals' attitudes and perceptions towards MNE, obtained from the International Social Survey Programme (ISSP, 2003 and 2013), with an indicator for the occupation‐country's exposure to MNE based on mergers and acquisitions data collected from the Securities Data Company Platinum database. Using an ordered probit model, we find that the MNE penetration at the occupation‐country level positively affects the individual's attitude towards MNE, even after controlling for individual socioeconomic characteristics. Additionally, we find that this effect is particularly relevant for individuals who are more favourable to immigrants' presence in their country and for residents in countries with high levels of employment protection legislation.