bluuebunny/crossref_metadata_2025_split huggingface dataset:
The immersive experience of virtual reality during chemotherapy in patients with early breast and ovarian cancers: The patient’s dream study
Authors: Fabi Alessandra , Fotia Luana , Giuseppini Federico , Gaeta Arianna , Falcicchio Chiara , Giuliani Gabriele , Savarese Antonella , Taraborelli Emanuela , Rossi Valentina , Malaguti Paola , Giannarelli Diana , Pugliese Patrizia , Cognetti Francesco 
Published: September 2022

BackgroundA virtual reality experience (VRE) could represent a viable non-pharmacological intervention to reduce and better manage the main factors of psychophysical distress related to the diagnosis and treatment of cancer.AimThe “Patient’s Dream” study was a two-arm randomized controlled trial conducted at the Regina Elena National Cancer Institute – IRCCS (Rome, Italy) from April 2019 to January 2020 to evaluate VRE impact in patients affected by breast or ovarian cancer. Before starting the first cycle of chemotherapy (CT), patients were randomized to receive the VRE (VRE arm) as “distraction therapy” or to entertain themselves with conventional means (control arm). The primary aims were the assessment of psychological distress, anxiety and quality of life between the two study arms. Secondary endpoints were the perceived time during the first course of CT and the acute and late toxicity.ResultsFourty-four patients were enrolled, 22 patients were randomly assigned to the VRE arm and 22 to the control arm. Collected data underline the absence of prevalent disturbs of anxiety and depression in both groups. Nevertheless, even if the state anxiety values before and after CT decreased in both groups, this reduction was statistically significant over time only in the VRE arm. The duration of therapy perceived by patients undergoing distraction therapy was significantly shorter when compared to the control group. The use of VRE during the first CT cycle appeared to reduce asthenia outcomes.ConclusionObtained data suggest that the VRE positively influenced the levels of state anxiety among cancer patients and support the continuous research on VRE as a distraction intervention, with the aim to meet the clinical need for effective nonpharmacologic adjunctive therapies.Clinical trial registrationhttps://clinicaltrials.gov/ct2/show/NCT05234996, identifier NCT05234996.
Real-world use of orphan medicinal products (OMPs) in rare disease (RD) patients: A population-based registry study
Authors: Mazzucato Monica , Minichiello Cinzia , Vianello Andrea , Visonà dalla Pozza Laura , Toto Ema , Facchin Paola 
Published: September 2022

Background: Despite calls for the use of real-world data, the rare diseases (RD) treatment landscape suffers from a scarcity of data referred to orphan medicinal products (OMP) use at the population level.Objectives: We aim to describe the characteristics and patterns of utilization of OMP in a sizable group of RD patients globally monitored by an area-based rare diseases registry located in the Veneto region, Italy, during a 3-year period (1 January 2019 to 31 December 2021).Methods: A list of OMP (n = 60) was assembled for study purposes, according to extensive criteria with regard to the status of orphan designation and of national reimbursement decisions.Results: OMP prescriptions involved 1,010 patients, corresponding to the 2.3% of all the patients monitored by the RD registry. Nearly one out of five (22.8%) was a pediatric patient at the time of the first prescription. OMP use interested a limited proportion (17.5%) of diseases approaching the rarity threshold, having a prevalence of less than five per 10,000, while individuals affected by these more common rare conditions represented 49% of all the patients receiving an OMP prescription. A clustering effect of OMP use was observed in selected groups of diseases, mainly, neurological, hematological, and hereditary metabolic ones. Medication plans including an OMP show in the 45.9% of the cases a high level of complexity, both in terms of nature and number of co-prescribed treatments. Off-label use interested 15.3% (n = 155) of all the RD patients with at least an OMP prescription during the study period.Conclusion: Data collected in a real-world setting through population-based registries globally monitoring RD patients, including related medication plans, have the potential to identify which diseases, and thus patients, have less benefit from the advent of OMP so far. Furthermore, in the rapidly evolving RD therapeutic landscape, they can help understand which therapeutic areas are most in need of investment to address existing unmet care needs.
Research and application of herbal medicine in the treatment of chronic kidney disease since the 21st century: A visualized bibliometric analysis
Authors: Xu Yunling , Chen Jia , Wang He , Lu Ying 
Published: September 2022

Background:Here, a bibliometric and knowledge-map analysis was used to analyze the research status and application of herbal medicine for the treatment of chronic kidney disease (CKD). By looking for research hotspots and key topics, we provide new clues and research directions for future research.Methods:Articles and reviews regarding herbal medicine in the treatment of CKD were retrieved from the Web of Science Core Collection on 23 May 2022. The R-bibliometrix, VOSviewer, and CiteSpace software were used to conduct the bibliometric and knowledge-map analysis.Results:In total, 5,920 authors at 1,330 institutions from 68 countries published 1,602 papers in 355 academic journals. China is the leader and pioneer in the research and application of herbal medicine in the field of CKD treatment. Beijing University of Chinese Medicine contributed the most publications. Ping Li (China-Japan Friendship Hospital) published the most articles, while Yingyong Zhao (Northwest University) had the most cocitations. However, cooperation among countries and the research institutions is not sufficient.Journal of Ethnopharmacologypublished the most research and application of herbal medicine in the treatment of CKD and was the most commonly co-cited journal. The most influential research hotspots about herbal medicine in the treatment of CKD focused on diabetic nephropathy-related research, Balkan endemic nephropathy, and pharmacokinetic study.Conclusion:Herbal medicine has a wide range of pharmacological activities and therapeutic value. The research and application of herbal medicine for the treatment of CKD, especially diabetic nephropathy, will remain a hot topic in the future.
Comparison between 2,000 m and 3,000 m time trials to estimate the maximal aerobic speed for collegiate runners
Authors: Du Zonghao , Lu Wei , Lang Diandong 
Published: September 2022

Considered to be a lesser resource burden, 2,000 and 3,000 m time trials (TTs) have been recognized as alternatives to accurately estimate the maximal aerobic speed (MAS) derived from laboratory-graded exercise testing (GXT). Previous studies have commonly used ordinary least squares linear regression and the Bland–Altman method to compare the agreement between MAS and TT performance. The agreement analysis aimed to identify the systematic bias between the results of the two methods, rather than to identify similarities. The model II regression technique (ordinary least product regression) is increasingly favored by researchers in the field of physiology. Thus, we aimed to 1) use the ordinary least product (OLP) and bootstrap methods to determine the agreement between the average speed of 2,000 m TT (S2000) and the average speed of 3,000 m TT (S3000) and 2) determine whether S2000 or S3000 can accurately approximate the GXT-derived MAS. It is used as an alternative to estimate the MAS and prescribe training intensity. Thirty-five Beijing Sport University recreational male runners completed an MAS test in laboratory settings, followed by 2,000 and 3,000 m TTs randomly, with a 7-day interval. OLP regression was used to analyze the agreement between the GXT-derived MAS and S2000 and S3000. The bootstrap method was used to calibrate the equations. Differences between the GXT-derived MAS and S2000 and S3000 were compared using a one-way repeated measure analysis of variance (ANOVA) and a post hoc analysis (Bonferroni). The significance level was p &lt; 0.05. The results showed that before calibration, the 95% CI of the OLP regression intercept and slope between the GXT-derived MAS and S2000 and S3000 did not include 0 and 1.00, respectively. These values, after calibration, included 0 and 1.00, respectively. Post hoc analysis revealed that S3000 closely approximated the GXT-derived MAS and underestimated 0.46% (0.06 km h−1 and p &gt; 0.05), and S2000 overestimated 5.49% (0.81 km h−1 and p &lt; 0.05) by the MAS. It concluded that the 3,000 m TT performance approximated the GXT-derived MAS compared to the 2,000 m TT performance. There exist fixed bias and proportional bias between the GXT-derived MAS and TT performance. More attention should be applied to calibration when using the TT performance to estimate the MAS.
Psychoeducation, motivational interviewing, cognitive remediation training, and/or social skills training in combination for psychosocial functioning of patients with schizophrenia spectrum disorders: A systematic review and meta-analysis of randomized controlled trials
Authors: Lu Erin Yiqing , Cheng Andy S. K. , Tsang Hector W. H. , Chen Juan , Leung Samuel , Yip Annie , Lin Jessie Jingxia , Lam Zoe Violet , Zhang Wufang , Zhao Miaomiao , Ma Ning 
Published: September 2022

ObjectivesPsychoeducation, motivational interviewing, cognitive remediation training, and social skills training have been found to be effective interventions for patients with schizophrenia spectrum disorders. However, their efficacy on psychosocial functioning when provided in combination remains unclear, compared with all types of control conditions. It would also be meaningful to explore the differences of efficacy in patients with first-episode psychosis (FEP) and those with longer term of illness.MethodologyThe present review followed the guidelines of Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). Full-text English journal articles of randomized controlled trials published in the past decade in the databases of PubMed, CINAHL Complete, Embase, and PsycINFO were searched. Included studies were all randomized controlled trials (RCTs) with participants diagnosed with schizophrenia spectrum disorders. The included studies should test combined interventions with at least two components from: psychoeducation, motivational interviewing, cognitive remediation training, and social skills training and incorporate assessment of psychosocial functioning at least at baseline and post-intervention.ResultsSeven studies were included for systematic review, and six of them were eligible for meta-analysis. Five out of the seven studies reported effects on psychosocial functioning that favored combined interventions over any type of control condition. A significant pooled effect was derived from the six studies, SMD = 1.03, 95% CI [0.06, 2.00], Z = 2.09, p = 0.04, I2 = 96%. However, the pool effect became insignificant when synthesizing five of the studies with non-FEP patients as participants and four of the studies testing relative effects of combined interventions compared with stand-alone interventions/interventions with one less component. None of the included studies adopted motivational interviewing and only one of the studies worked with FEP patients.ConclusionPsychoeducation, cognitive remediation training, and social skills training in combination can effectively enhance psychosocial functioning of patients with schizophrenia spectrum disorders. It is warranted to conduct more RCTs to test the effects of different specific combinations of the above interventions on psychosocial functioning, especially in FEP patients.
Association between maternal shift work during pregnancy child overweight and metabolic outcomes in early childhood
Authors: Liao Che-Wei , Wei Chih-Fu , Chen Mei-Huei , Hsieh Wu-Shiun , Lin Ching-Chun , Chen Pau-Chung 
Published: September 2022

BackgroundPrevious studies found that maternal shift work during pregnancy was associated with many reproductive hazards, including small for gestational age, preterm birth, stillbirth, and neurodevelopmental impairment. Some studies also showed that these children are more likely to become overweight in early childhood. However, the association with metabolic factors, such as insulin resistance and dyslipidemia, was less studied. Hence, we aimed to understand better the relationship between maternal shift work during pregnancy and the risk of childhood overweight and metabolic outcomes. Confounding factors were also discussed, including diet, exercise, and demographical factors.MethodsWe enrolled pregnant women before delivery in the Taiwan Birth Panel Study (TBPS) II conducted between 2010 and 2012, and followed the children of these participants in 2018. The objective of this study is to investigate the influence of prenatal and postnatal factors on infant and early childhood health. During the follow-up in 2018, we checked children's demographic data, obtained blood specimens, and checked their blood sugar, blood insulin, and lipid profiles. Structured questionnaires were used to evaluate demographic data. Multiple linear and logistic regressions were used to examine the associations between maternal shift work during pregnancy and child overweight, metabolic disorders, such as HOMA-IR, and lipid profiles.ResultsIn this study, we included 407 mother-children pairs with different work shifts (350 day workers and 57 shift workers), and a sub-population without underweight children was also created (290 day workers and 47 shift workers). Shift work during pregnancy was associated with a higher Homeostasis Model Assessment-Insulin Resistance index (HOMA-IR) and a higher odds ratio for overweight in children born from mothers doing shift work during pregnancy after adjustment. The findings were attenuated when we investigated the effect of shift work before pregnancy.ConclusionOur study suggested that maternal shift work during pregnancy was associated with child overweight and insulin resistance in early childhood.
Digital physiotherapy intervention in children in a low resource setting in Anantapur (India): Study protocol for a randomized controlled trial
Authors: Estebanez-Pérez María-José , Martín-Valero Rocío , Moreno-Morales Noelia , Liñán-González Antonio , Fernández-Navarro Rocío , Pastora-Bernal José-Manuel 
Published: September 2022

IntroductionIn rural India the scarcity of physiotherapists and inequalities complicate the recovery of traumatized children. This study protocol will explore a digital physiotherapy intervention in children with ankle fracture in a low-resource setting to improve functional independence and quality of life.Methods and analysisA randomized clinical trial with a mixed quantitative-qualitative design will be carried out. It is a single-blind study, where the evaluator does not know the nature of the intervention. Sixty subjects will be enrolled and randomly divided into two groups: the experimental group (EG) will receive a 4-week digital physiotherapy intervention through an app in a recycled mobile device after hospital discharge; the control group (CG) will receive the physiotherapy standard care recommended for patients discharged from the hospital. Subjects will receive a baseline (T0-pre) assessment of Functional Independence and Quality of Life. At the end of the 4-week intervention (T1-post) a new assessment of the outcome will be performed adding data on adherence, satisfaction (ad hoc questionnaire and TSQ), and barriers of use. Qualitative outcomes will also be explored. The author's hypothesized that the implementation of a digital physiotherapy intervention is feasible and effective to improve functional independence and quality of life. This study protocol is the first to explore the effect of digital physiotherapy intervention in children's patients in a low resource setting (Anantapur).DiscussionThe successful delivery of the intervention, an optimal adherence records, the absence of significant adverse effects, user satisfaction level and the qualitative analysis of limitations, will demonstrate the effectiveness of these procedure. This study will add more evidence in support the use of digital physiotherapy practice as an effective tool. User particularities, provider's capacity, technological and cultural limitations, and considerations for vulnerable populations will be taken into account.Clinical trial registrationNCT04946695 (https://clinicaltrials.gov/).
Related Risk Factors of Early Childhood Caries in Zhejiang Province, China During the COVID-19 Pandemic
Authors: Huang Chaoqiang , Zhu Kangqi , Feng Yibing , Lian Luya , Zhu Haihua , Hu Jian 
Published: September 2022

ObjectivesThis work aims to examining the latest early childhood caries situation in children aged 3 and 5 and its related risk factors in Zhejiang Province during the COVID-19 pandemic.MethodThere are 3,537 children and their main caregivers participate in this study. We used chi square test or U-test to analyze whether there were differences in the prevalence of dental caries under different variables. The risk factors on ECC were determined by multivariate logistic analysis.ResultsThe ECC rate of children in this study was 57.51%. The mean decayed missing filled teeth (dmft) scores were 3.01. The result of multivariate logistic analysis showed higher ECC prevalence was found in children as age increasing, with lower district economic level, with high frequency of confectionary consumption, having oral medical treatment behavior and bad evaluation of children's oral health by parents.ConclusionIn general, the prevalence rate of ECC in this study was lower than five years ago, but still higher than those developed countries. And it was associated with age, district economic level, frequency of confectionary consumption, oral medical treatment behavior and evaluation of children's oral health by parents.
Hasil Benih Kentang yang diberi Pembenah Tanah pada Perbedaan Waktu Panen
Authors: Dewi Dian Krisdayani , Parlinah Linlin , Budiasih R. , Amalia Lia 
Published: September 2022

This article aims to determine the effect of the dose of soil dressing enriched with Phosphate solubilizing bacteria on the difference in harvest time on the yield of potato seeds. The environmental design used was a Randomized Group Design (RGD), there were nine treatments and each treatment was repeated 3 times. The combination of treatments tested as follows: A= control harvested at the age of 90 DAP, B= control harvested at the age of 100 DAP, C= control harvested at the age of 110 DAP, D= soil reformer 10 tons ha-1 in harvest 90 DAP, E= soil reformer 10 tons ha-1 harvested 100 DAP, F= soil reformer 10 tons ha-1 harvested 110 DAP, G= soil reformer 20 ha-1 harvested 90 DAP, H= soil reformer 20 tons ha-1 harvested 100 DAP and I= soil reformer 20 ha-1 harvested 110 DAP. The results showed that the administration of various doses of soil reformers that had been enriched with PSB was able to increase plant height, number of leaves, number of planting tubers and weight of planting tubers when compared to controls. The best response was shown from a dose of soil dressing treatment of 10 tons of ha-1 at harvest time of 100 DAP.
Faktor-Faktor Yang Mempengaruhi Efektivitas Pelayanan Sistem Resi Gudang (Srg) Dan Manfaatnya Kepada Petani Padi ( Kasus di Kecamatan Warungkondang, Kabupaten Cianjur, Jawa barat )
Authors: Yusuf Ilham Maulana , Dasipah Euis , KS Karyana 
Published: September 2022

This research aims to find out the factors that affect the service function of warehouse receipt system (SRG) and its benefits to farmers. Theanalysis is the farmer utilizing SRG services. The technique of determining respondents is done from the withdrawal of examples with a simple random technique, The sample size using the Slovin formula was obtained by 60 people. Hypothesis testing analysis techniques used multiple linear regression analysis and chisquare. The results of the research obtained by Fator-factors that affect the service function of The Warehouse Receipt System (SRG) to farmers in Warungkondang District, Cianjur Regency are: land area, harvest area, land productivity, dependence on marketing agencies, capital, and the effectiveness of HPP (Government Purchase Price) policy. The achievement rate is 78.75%. SRG Service functions to farmers include: storage, grain quality test; delivery of goods, supervision, and cooperation. The achievement rate was 77.33%. The benefits of SRG in order to provide services to farmers include: better price / higher, product quality, quantity of products, and financingguarantees. The achievement rate is 69.06%. Factors that have a real effect on the function of SRG services are: land area, harvest area, land productivity, and capital, while the effect is not real, namely: dependence on capital release, and HPP policy. The function of SRG services has a positive effect on the benefits obtained by farmers. With the understanding of the better the running of the SRG function, the better it will provide the benefits obtained by farmers.
Penerapan Nadhom Dalam Melantunan Alqur’an Pada Usia Anak-Anak
Authors: Syaripudin Cecep Rif’at , Imam Tabroni  
Published: September 2022

Salah satu mu’zizat yang diturunkan kepada Nabi Muhammad SAW adalah al-Qur’an. Al-Qur’an itu agung sudah sepantasnya diperlakukan juga secara agung pula,diantara nya dengan cara melantunkan al-Qur’an dengan memakai naghom (lagu atau irama membaca al-Qur’an). Meskipun tajwidlah yang terpenting didalam melantunkan ayat-ayat didalam al-Qur’an tapi melantunkan al-Quran dengan naghom juga hal yang penting yang harus dilakukan oleh seorang qori atau pelantun al-Qur’an didalam melantunkan al-Qur’an, bahkan orang yang melantunkan al-Qur’an tidak dengan nada, kata Rosul bukan termasuk umat kami. Naghom dalam seni baca al-Quran menurut para ahli itu ada delapan macam naghom pokok atau lagu pokok namun yang dipakai di Indonesia adalah tujuh naghom pokok atau lagu pokok,kemudian dari lagu pokok ini lahir nagho/lagu cabang,ada delapan belas lagu cabang yang lahir dari lagu-lagu pokok. Bagi orang yang melantunkan al-Qur’an memiliki lima keutamaan sebagaimana yang telah dibahas oleh ‘ulama dalam kitab riyadhussoolihiin. Al-Quran itu agung menjadi keharusan bagi kita selaku umat islam mengagungkan al-Qur’an,ada tata krama yang harus dilakukan ketika kita sedang membaca al-Qur’an,diantaranya yaitu kita diwajibkan memiliki wudhu terlebih dahulu apabila mau memegangnya, membaca ta’awudz dan basmalah ketika akan membaca-nya dan menundukkan kepala ketika sedang membaca-nya. Al-Quran adalah obat bagi penyakit dzohir maupun penyakit bathin,ketika kita sedang dalam keadaan resah dan gelisah bacalah al-Qur’an dengan penuh keikhlasan.