bluuebunny/crossref_metadata_2025_split huggingface dataset:
Folate intake and risk of colorectal cancer: a systematic review and up-to-date meta-analysis of prospective studies
Authors: Fu Hongjuan , He Jianbo , Li Cancan , Deng Zhihui , Chang Hui 
Published: May 2022

Purpose
Colorectal cancer is one of the most commonly diagnosed and deadly cancers worldwide. Epidemiological studies on the relationship between folate intake and the risk of colorectal cancer have reported inconsistent findings since folate fortification in the USA. For this situation, we conducted a large number of data analyses to study the relationship between folate intake and colorectal cancer risk.

Methods
PubMed and EMBASE databases were used to search the literature systematically. Eligible studies were reviewed and meta-analyzed to assess the relationship.

Results
A total of 24 cohort studies involving 37 280 patients and 6 165 894 individuals were included. The results showed that high folate intake was associated with a reduced risk of colorectal cancer. The combined relative risk (RR) for the highest intake compared with the lowest was 0.88 [95% confidence interval (CI), 0.83–0.92, P = 10−4). Further studies indicated that the increase of folate intake may decrease the risk of colorectal cancer in people with medium or high alcohol consumption (RR = 0.97, 95% CI: 0.96–0.99, P = 0.008; RR = 0.95, 95% CI: 0.92–0.98, P  =  0.003), but not in non-drinkers (RR = 1.00, 95% CI: 0.98–1.02, P = 0.827). Next, high folate intake may decrease the risk of colon cancer (RR = 0.86, 95% CI: 0.81–0.92, P = 10−4) but not rectal cancer (RR = 0.92, 95% CI: 0.84–1.02, P = 0.112). Additionally, the result that high folate intake may decrease the risk of colorectal cancer was observed in the USA and Europe but not in other regions.

Conclusion
High folate intake may be protective against colon cancer, particularly in people with middle or high alcohol consumption, but it still needs to be further confirmed.
Women’s attitudes towards healthy life awareness and breast cancer screening during the coronavirus disease 2019 pandemic: a cross-sectional descriptive study
Authors: Çinar Derya , Çelik Ayşegül , Öztürk Aslihan , Zorba Bahçeli Pinar , Kiliç Akça Nazan 
Published: May 2022

Background
In the COVID-19 pandemic, fear of coronavirus infection has caused individuals to hesitate to access medical services and postpone their participation in diagnostic and screening programs. With this research, it was aimed to examine the relationship between women’s wellness awareness and attitudes towards breast cancer screening during the COVID-19 pandemic.

Methods
The descriptive cross-sectional type research was conducted between 30 January 2021 and 30 July 2021. The sample of the study consisted of 396 women between the ages of 40 and 69 who were in the breast cancer screening population under national cancer screening standards and met the criteria for inclusion. The data of the study were collected using a web-based and self-reported questionnaire, Personal Information Form, Healthy Life Awareness Scale and Cancer Screening Attitude Scale.

Results
It was determined that more than half of women postponed breast cancer screening during the COVID-19 pandemic, and the reasons for the postponement were often fear of contamination. It was determined that there was a relationship between the participants’ awareness of healthy living and their attitudes towards cancer screening (P < 0.05).

Conclusion
It was found that approximately two out of every three women in the screening population during the pandemic did not have screening or postponed it due to fear of contamination. It was determined that women who had awareness of healthy living and had breast cancer screening before the pandemic had a positive attitude towards cancer screening during the COVID-19 pandemic period.
Update on Exosomes in Aesthetics
Authors: Hartman Nina , Loyal Jameson , Fabi Sabrina 
Published: May 2022

BACKGROUND
In dermatology, exosomes have been leveraged given their roles in wound healing, cell migration, extracellular matrix reconstruction, and angiogenesis.

OBJECTIVE
The purpose of this article is to review the literature investigating the use of exosomes in skin rejuvenation and hair regeneration.

MATERIALS AND METHODS
The PubMed database was searched for studies published through October 2021.

RESULTS
Early preclinical studies in aesthetics have demonstrated promising effects of exosomes on skin rejuvenation and hair growth in in vitro and murine models. Despite this, only 1 clinical study has been published to date, and there are no FDA-approved products on the market.

CONCLUSION
Variation in purification techniques and practical issues surrounding isolation, storage, scalability, and reproducibility of an exosome product represent ongoing hindrances to the movement of exosomes into the clinical sphere.
Change in Risk Score and Behaviors of Soft Contact Lens Wearers After Targeted Patient Education
Authors: Lam Dawn , Wagner Heidi , Zimmerman Aaron B. , Rosner Bernard , Kinoshita Beth , Mickles Chandra , Mitchell G. Lynn , Moreno Megan , Richdale Kathryn 
Published: May 2022

Objectives:
To determine if targeted education can influence the behaviors and scores of soft contact lens (SCL) wearers via the Contact Lens Risk Survey (CLRS).

Methods:
This was a multicenter, prospective, case–control study. Cases were symptomatic red eye SCL wearers (age, 18–39 years), and controls were age , sex, and site matched. Participants completed the CLRS and were provided targeted patient education at three time points: baseline, one, and six months. Change in scores and behaviors were analyzed using the Wilcoxon signed rank test.

Results:
Forty-one cases and 71 controls were analyzed. The mean risk score (mean±SE) from baseline to follow-up improved (reduced) for all participants (−1.96±0.73; P=0.01), mostly driven by the improvement among cases (−2.55±1.32; P=0.05). Case subjects reported a decrease in frequency of wearing lenses while showering (−0.32±0.07; P<0.0001), discarding lens solution (−0.13±0.06; P=0.03), and rinsing lenses with tap water (−0.19±0.08; P=0.02) after targeted education.

Conclusions:
Targeted patient education can influence some behaviors of SCL wearers, especially those who experienced a red eye event. Further study is needed to determine how to improve other risk behaviors and whether these changes are sustained long term.
Human Endogenous Retroviruses and Hematological Malignant Tumors
Authors: Li Tianfu , Li Hanping , Li Lin , Li Jingyun 
Published: May 2022

Abstract
Human endogenous retrovirus (HERV) gene sequences are remnants of retroviruses that infected the ancestors of humans millions of years ago and were integrated into human chromosomes, accounting for approximately 8%–9% of the human genome. Most integrated HERVs have lost their coding capacity and remain silent due to frame shifts, mutations, and sequence deletions or insertions over the millions of years, but their expression is highly regulated by epigenetic and host defense mechanisms. However, there are still some HERV genes that have intact open reading frames due to recent integration into the human genome or positive selective pressure. The abnormal activation of HERVs may contribute to diseases or their pathology, such as malignant tumors, autoimmune diseases, and nervous system diseases. The occurrence and development of hematological malignant tumors (HMTs) is a complex process involving interactions of multiple genetic and environmental factors. The abnormal activation of HERVs may contribute to the pathology of HMTs via indirect mechanisms. In this review, we address the discovery of endogenous retroviruses in vertebrates, and the classification and genomic structure of HERVs. Among HERV family members, HERV-K is the latest type of HERV integrated into the human genome and it has the strongest transcriptional activity. We explore the currently known expression of HERV-K proto-oncogenes in HMTs and further address potential research and therapeutic approaches. However, much remains to be learned about not only the impact of HERVs on the occurrence of HMTs, but also the potential value of HERVs as diagnostic and therapeutic targets for HMTs.
Association between troponin and outcome in patients with chest pain and rapid atrial fibrillation: a retrospective study of a single-center 10-year cohort
Authors: García Ana , Miota Natalia , Miró Òscar , López-Ayala Pedro , López-Barbeito Beatriz , Strebel Ivo , Xipell Carolina , Fuenzalida Carolina , Martínez-Nadal Gemma , Boeddinghaus Jasper , Nestelberger Thomas , Twerenbold Raphael , Mueller Christian , Coll-Vinent Blanca 
Published: May 2022

Background and objective
The prognosis of myocardial infarction in patients with rapid atrial fibrillation (RAF) is poorly known. We sought to ascertain if troponin concentrations are associated with a higher risk of major adverse cardiovascular events (MACE) in patients with RAF and chest discomfort suggestive of coronary origin.

Methods
We retrospectively reviewed all consecutive patients attending an emergency department of a single-center (2008–2017) with chest pain suggestive of coronary origin who had RAF and at least one troponin determination. Patients were classified as having normal/increased troponin. They were followed until December 2019 to detect MACE (primary outcome), which included acute coronary syndrome (ACS), revascularization, stroke, or all-cause death. In addition to cardiovascular death and type I myocardial infarction, these were considered secondary outcomes. The adjusted risk was determined by Cox regression, and sensitivity analysis were run. Relationship between troponin as a continuous variable and outcomes was also evaluated, as well as interaction by sex.

Results
We included 574 patients (median = 76.5 years, IQR = 14, women 56.8%, increased troponin 34.1%) followed by a median of 3.8 years (IQR = 4.8). MACE occurred in 200 patients (34.8%). Increased troponin was independently associated with MACE (adjusted hazard ratio, 1.502, 95% CI, 1.130–1.998), ACS (adjusted hazard ratio, 2.488, 95% CI, 1.256–4.928), type I myocardial infarction (adjusted hazard ratio, 2.771, 95% CI, 1.212–6.333) and stroke (adjusted hazard ratio, 3.580, 95% CI, 1.888–6.787) but not with death, cardiovascular death or revascularization. Sensitivity analyses were consistent with these results. There was no interaction by sex. When assessed continuously, an increase in troponin concentrations was lineally associated with a steady increase in the risk of MACE.

Conclusions
In patients with RAF who complain of chest pain, increased troponin levels are related to adverse cardiovascular outcomes.
Outcomes of the First 54 Pediatric Patients on Long-Term Home Parenteral Nutrition from a Single Brazilian Center
Authors: Goldani Helena A.S. , Ceza Marilia R. , Godoy Liege L. , Giesta Juliana M. , Beier Simone , Oliveira Juliana G. , Nunes Daltro L. , Feldens Leticia , Lucena Iara R.S. , Taniguchi Adriano N.R. , Hallberg Silvia C. , Durant Daiane , Boettcher Simone , Schneider Marcia A. , Mello Patricia P. , Riberg Mariana G.L. , Signorini Alana V. , Miller Cristina , Santos Berenice L. , Silveira Claudete O. , Morais Maira C.M. , Laggazio Terezinha V. , Costa Carla C. , Kieling Carlos O. 
Published: May 2022

Objectives:Data on multidisciplinary programs dedicated to home parenteral nutrition (HPN) in Latin America are limited. This study describes the results of the first multidisciplinary pediatric intestinal rehabilitation program for HPN at a public tertiary hospital in Brazil.Methods:We retrospectively reviewed patients aged 0–18 years with intestinal failure (IF) who required parenteral nutrition (PN) for >60 days between January/2014 and December/2020.Results:Fifty-four patients were discharged on HPN (15 achieved enteral autonomy, 34 continued on HPN at the end of the study, 1 underwent intestinal transplantation, and 4 died). The median (IQR) age at the study endpoint of patients who achieved enteral autonomy was 14.1 (9.7–19) versus 34.7 (20.4–53.9) months in those who did not achieve enteral autonomy. Overall prevalence of catheter-related thrombosis was 66.7% and catheter-related bloodstream infection rate was 0.39/1000 catheter-days. Intestinal failure-associated liver disease (IFALD) was present in 24% of all patients; none of the patients who achieved enteral autonomy had IFALD. All patients showed significant improvement in anthropometric parameters during the HPN period. The sociodemographic characteristics of the patients’ family members were mothers less than 20 years old (7.5%), schooling time more than 10 years (55.5%), and household income between 1 and 3 times the minimum wage (64.8%). The 5-year survival rate for HPN is 90%, and 27.7% of patients achieve enteral autonomy.Conclusion:The treatment of pediatric patients with IF followed by a multidisciplinary pediatric intestinal rehabilitation program with HPN is feasible and safe in the Brazilian public health system.
Ubi-Flex-Cloud: ubiquitous flexible cloud computing: status quo and research imperatives
Authors: Thyagaturu Akhilesh S , Nguyen Giang , Rimal Bhaskar Prasad , Reisslein Martin 
Published: May 2022

PurposeCloud computing originated in central data centers that are connected to the backbone of the Internet. The network transport to and from a distant data center incurs long latencies that hinder modern low-latency applications. In order to flexibly support the computing demands of users, cloud computing is evolving toward a continuum of cloud computing resources that are distributed between the end users and a distant data center. The purpose of this review paper is to concisely summarize the state-of-the-art in the evolving cloud computing field and to outline research imperatives.Design/methodology/approachThe authors identify two main dimensions (or axes) of development of cloud computing: the trend toward flexibility of scaling computing resources, which the authors denote as Flex-Cloud, and the trend toward ubiquitous cloud computing, which the authors denote as Ubi-Cloud. Along these two axes of Flex-Cloud and Ubi-Cloud, the authors review the existing research and development and identify pressing open problems.FindingsThe authors find that extensive research and development efforts have addressed some Ubi-Cloud and Flex-Cloud challenges resulting in exciting advances to date. However, a wide array of research challenges remains open, thus providing a fertile field for future research and development.Originality/valueThis review paper is the first to define the concept of the Ubi-Flex-Cloud as the two-dimensional research and design space for cloud computing research and development. The Ubi-Flex-Cloud concept can serve as a foundation and reference framework for planning and positioning future cloud computing research and development efforts.
Investigations on the formability, tensile properties, TEM, 3D-surface roughness and corrosion behaviour on Ti–6Al–4V alloy sheets during single point and multi point incremental forming process
Authors: Heruthunnisa Shaik , B. Chandra Mohana Reddy 
Published: May 2022

Purpose
The purpose of this paper is to study formability, tensile properties, dislocation density and surface roughness of incrementally deformed Ti–6Al–4V alloy sheets during single-point incremental forming (SPIF) and multi-point incremental forming (MPIF) process. The development of corrosion pits in 3.5% NaCl solution has also been studied during SPIF and MPIF processes.

Design/methodology/approach
In this study, the formability, tensile properties, dislocation density, surface roughness and corrosion behaviour of deformed Ti–6Al–4V alloy sheets were studied. A potentio-dynamic polarization (PDP) study was conducted to study the corrosion behaviour of Ti–6Al–4V alloy samples during SPIF and MPIF processes and the results were also compared with base material (BM) in 3.5% NaCl solution. Scanning electron microscopy (SEM) and transmission electron microscopy (TEM) analyses were carried out to study the corrosion morphology and dislocation densities of deformed samples.

Findings
The deformed Ti–6Al–4V alloy sheets obtained higher plastic deformation, high tensile strength, good surface roughness and good corrosion resistance during MPIF process when compared with SPIF process.

Research limitations/implications
It has been concluded that the maximum strain and good corrosion resistance have been achieved with MPIF process, which in turn increases the plastic deformation as compared with BM.

Practical implications
This study discussed the formability, tensile properties, surface roughness and corrosion behaviour of deformed Ti–6Al –4V alloy sheets during incremental sheet forming (ISF) process.

Social implications
This study is useful in the field of medical, industrial and automobile applications.

Originality/value
The Ti–6Al–4V alloy is deformed using MPIF process, achieving better formability, tensile strength, good surface roughness and corrosion rate, and the same is evidenced in forming limit diagrams (FLDs) and PDP curves.
Understanding customers’ stickiness of live streaming commerce platforms: an empirical study based on modified e-commerce system success model
Authors: Bao Zheshi , Zhu Yan 
Published: May 2022

PurposeLive streaming commerce enhances shopping experience and reduces uncertainty. However, with increasingly fierce competitions, it has become a challenging task for live streaming commerce platforms to retain existing customers. The purpose of this study to explore factors affecting customers’ stickiness intention toward live streaming commerce platforms.Design/methodology/approachA research model was developed by modifying e-commerce system success model (ES success model) based on the context of live streaming commerce and meanwhile integrating serendipity and flow into the model. Using the data collected from 380 customers who have live streaming shopping experience, the established model was empirically assessed by partial least squares based structural equation model.FindingsThe results show that vividness, real-time interaction and diagnosticity are antecedents of perceived value and customer satisfaction toward a live streaming commerce platform which in turn influence customers’ stickiness intention. Besides, as new factors introducing into the ES success model, serendipity and flow are two important motivators of satisfaction and stickiness.Originality/valueThis study establishes a well-organized framework to understand the mechanism regarding why customers stick with a live streaming commerce platform. It provides a socio-technical approach to analyze how the stickiness intention can be influenced.
Internal organizational networks and green innovation performance in Chinese new ventures: the roles of corporate proactive environmental strategy and the regulatory quality
Authors: Sebaka Lapologang , Zhao Shuliang 
Published: May 2022

PurposeSynthesizing from the institutional theory and social network theory, this study investigates factors influencing green innovation performance in new ventures.Design/methodology/approachThe findings show that the dimensions of internal social network; heterogeneous network and tie strength have significant positive effects on proactive environmental strategy based on a sample of 300 new ventures in China.FindingsThe results further support the mediating role of proactive environmental strategy on internal organizational networks and green innovation performance of new ventures. The study further investigated the moderating role of the regulatory quality as a dimension of institutional environment in China. The results show that the regulatory quality positively moderates the relationship between proactive environmental strategy and green innovation performance. Policy and managerial implications are further discussed.Originality/valueOver the past 20 years, green innovation has increasingly attracted the attention of policymakers and scholars. However, most studies have focused on mature ventures, and little attention has been given to how newly established ventures attain green innovation performance.
Local government’s role in promoting city hospitality: a meta-ethnography with a public management perspective
Authors: Del Gesso Carla , Lodhi Rab Nawaz , Cobanoglu Cihan 
Published: May 2022

Purpose
Adopting a public-management perspective, this study aims to conduct a meta-ethnography to discern local government’s role in city hospitality in terms of promoting the welcome the city gives its guests, filling a gap in research into the subject.

Design/methodology/approach
The authors used the seven-step iterative approach of Noblit and Hare’s meta-ethnography. By conducting a systematic search in the major bibliographic databases, ten qualitative studies on city hospitality were identified that met the criteria to be included. Concepts alluding to a local government’s role in city hospitality were coded in NVivo 11 software, translated and interpreted through the lens of public management. A total of 14 semi-structured interviews with experts were also conducted to further validate the meta-ethnography findings.

Findings
Six interrelated, third-order constructs were developed and conceptualized into an articulated model describing local government’s role in city hospitality from a public-management perspective: advocating, co-creating, strategizing, planning and implementing city hospitality, and promoting it into a sustainable tourism development. The model, also substantiated by expert feedback, describes local government actions to promote city hospitality and achieve sustainable tourism. It highlights a responsive, proactive and collaborative role for local government as a key actor responsible for the strategic management and co-creation of city hospitality.

Research limitations/implications
The study introduces public governance cues into a city hospitality context, with theoretical and practical implications for hospitality and tourism researchers, businesses, politicians, public managers, city officials and destination marketing/management practitioners.

Originality/value
The study proposes an original conceptual model that serves as an overarching framework and operative tool for understanding and practicing city hospitality in a contemporary public-management perspective. This lays the foundations for the development of a broadened notion of hospitality management, extended from the traditional context of the hospitality industry to that of the city or place. The study also showcases how meta-ethnography can be an effective methodology in business, management and accounting research, within which it is still a novelty.