bluuebunny/crossref_metadata_2025_split huggingface dataset:
Circadian skin temperature rhythm and dysautonomia in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: the role of endothelin-1 in the vascular dysregulation
Authors: Cambras Trinitat , Zerón-Rugerio Maria Fernanda , Díez-Noguera Antoni , Zaragoza Maria Cleofe , Domingo Joan Carles , Sanmartin-Sentañes Ramon , Alegre-Martín Jose , Castro-Marrero Jesus 
Published: September 2022

Abstract
Purpose
There is accumulating evidence of autonomic dysfunction in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS); however, little is known about its association with circadian rhythms and endothelial dysfunction. This study aimed to explore the relationship between autonomic responses using an orthostatic test, skin temperature circadian variations, and circulating endothelial biomarkers in ME/CFS.
Methods
Sixty-seven adult female ME/CFS patients and 48 matched healthy controls were enrolled. Demographic and clinical characteristics suggestive of autonomic disturbances were assessed using validated self-reported outcome measures. Postural changes in blood pressure [BP], heart rate [HR], and wrist temperature (WT) were recorded during the orthostatic test. Actigraphy during one week was used to determine the 24-hour profile of peripheral temperature and motor activity. Circulating endothelial biomarkers were also measured as indicators of endothelial functioning.
Results
ME/CFS patients showed higher BP and HR values than healthy controls at rest (p < 0.05 for both), and also higher amplitude of the circadian activity rhythm (p < 0.01). Circulating levels of endothelin-1 (ET-1) and vascular cell adhesion molecule-1 (VCAM-1) were significantly higher in ME/CFS (p < 0.05). In ME/CFS, ET-1 levels were associated with the stability and amplitude of the temperature rhythm, (p < 0.01), and also with the self-reported questionnaires (p < 0.001).
Conclusions
ME/CFS patients exhibited alterations in circadian rhythms and hemodynamic measures that are associated with endothelial dysfunction, supporting previous evidence of dysautonomia in ME/CFS. Future investigation in this area is needed to assess vascular tone abnormalities and dysautonomia which may provide therapeutic targets for ME/CFS.
Oral corticosteroids abuse for the purpose of weight gain : First assessment in Algeria
Authors: Hadjilah Meriem , Fiala Sarah 
Published: September 2022

Abstract
While it is generally recognised that drug abuse only concerns illicit drugs and narcotics, other classes of medicines can also be abused such as oral corticosteroids; the use of which has been diverted for the purpose of gaining weight in many developing countries.
The aim of this study was to investigate the possibility of an abuse of oral corticosteroids for the purpose of weight gain in the Algerian population and assess its extent and sociodemographics. A questionnaire was designed to extract sociodemographic information and clinical history from participants. The patients included in the study were recruited from all subjects who had shown an interest in weight gain.
One hundred and eleven individuals out of 600 (18.5% used corticosteroids for the purpose of weight gain with an average age of 25.62 ± 5.62 years old; and an over-representation of women (N=70, 63.1%, P<0.05). The majority of participants (N=71, 63.97%) obtained the drugs directly from a pharmacy with no medical prescription.
A significant number of the Algerian population interested in gaining weight is involved in corticosteroids abuse; this issue raises the need for public awareness of the potential adverse effects of corticosteroids and their devastating consequences.
Epithelial Cell Adhesion Molecule (Epcam) CD9 Present as High Receptivity and Stem Cell-Like in Endometrium Cells
Authors: Wang Jun , Yang Minyan , Zhou Zheng , Li Peifan , Zhou Ying , Long Aizhuan , Zhao Shuyun 
Published: September 2022

Abstract
The endometrium is the dynamic layer which functional layer differentiation, proliferation and regeneration follow by menstruation and estrous cycle, receptivity and decodialization is vital for endometrium fertility. Epcam and CD9 have been proved expression on embryonic stem (ES) cells, however, functions underpinning the roles of Epcam and CD9 in endometrium receptivity, regeneration and regulating expression of estrogen and progesterone remain incompletely understood. Fertility women and infertility patients endometrium cell sample were collected and detected by flow cytometry, Western blot and Q-PCR. Primary Epcam + CD9 + and Epcam-CD9- endometrium cells sorted by cell cytometry then test the expression of receptivity factors, stem-cell-like factors and decidualized factors by Western Blot and Q-pcr. Primary endometrium cells were cultured in the medium addition with of estrogen, progesterone, fulvestrant and mifepristone, respectively. Statistical analyses were performed by using Pearson's correlation analysis and unpaired samples T-test. Fertile women endometrium cell samples shown higher expression of receptivity, EPCAM and CD9 expression compared with infertility patient samples, and Epcam or CD9 positive corrected receptivity factors (P < 0.05). Epcam + CD9 + endometrium cells were highly expression in fertility women than infertility patients samples(P < 0.05). Primary sorted Epcam + CD9 + endometrium cells illustrated higher expression of receptivity factors, stem-cell-like factors and decidualized factors than Epcam-CD9- in endometrium cells(P < 0.05). Primary endometrial cell culture with estrogen, progesterone, fulvestrant and mifepristone, respectively.Our results have shown Epcam adhesion factor and CD9 associated with endometrium receptive and regeneration, and shed light on the possibility of receptivity marker (Epcam + CD9+) of endometrial epithelial cells for stem cell biology studies.
Deep learning framework for the robust prognosis of Tuberculosis from radiography images based on fused linear triangular interpolation
Authors: Sasikaladevi N , A Revathi 
Published: September 2022

Abstract
Background
Despite being treatable and preventable, Tuberculosis (TB) affected one-fourth of the world population in 2019, and it took the lives of 1.4 million people 2019. It affected 1.2 million children around the world in the same year. As it is an infectious bacterial disease, the early diagnosis of TB prevents further transmission and increases the survival rate of the affected person. One of the standard diagnosis methods is the sputum culture test. It usually takes one to eight weeks for diagnosis and rapid sputum test results in 24 hours. The bacteria spreads rapidly during this period of diagnosis, which severely impairs the status of the infected person. The use of posterior-anterior chest radiographs (CXR) facilitates a rapid and more cost-effective early diagnosis of Tuberculosis. Due to intraclass variations and interclass similarities in the images, TB prognosis from CXR is difficult.
Method
This work suggests an effective early TB diagnosis system based on deep learning. Deep Fused Linear Triangulation (FLT) is considered for CXR images to reconcile intraclass variation and interclass similarities. To improve the robustness of the prognosis approach, deep information must be obtained from the minimal radiation and uneven quality CXR imaginings. The advanced FLT method accurately visualizes the infected region in the CXR without segmentation. Deep fused images are trained by the Deep learning network (DLN) with residual connections.
Results
The largest standard database, comprised of 3500 TB CXR images and 3500 normal CXR images, is utilized for training and validating the recommended model. Specificity, sensitivity, Accuracy, and AUC are estimated to determine the performance of the proposed systems. Considering existing cutting-edge deep learning approaches for the prognosis of Tuberculosis, the designed scheme exhibits maximum testing accuracy of 99.2%, a sensitivity of 98.9%, specificity of 99.6%, a precision of 99.6%, and AUC of 99.4%, all of which are very high.
Conclusions
To lessen the radiologist's time, effort, and reliance on the level of competence of the specialist, the suggested system named tbXpert can be deployed as a computer-aided diagnosis technique for Tuberculosis.
The single-cell atlas of the heart reveals an unexpected erythrocyte-like cardiomyocyte
Authors: Li Yanfei , Shen Junwei , Ma Linlin , Hu Jing 
Published: September 2022

Abstract
Single-cell RNA sequencing (scRNA-seq) is widely used in cancer research and organ development since its powerful ability to analyze cellular heterogeneity. However, its application in cardiomyocytes is rare mainly because the cardiomyocytes are too large and fragile to withstand traditional single-cell approaches. Through designing the isolation procedure of neonatal mouse cardiac cells, we provide detailed cellular atlases of the heart at single-cell resolution across four different stages after birth. We have luckily obtained tens of thousands of cardiomyocytes, to our knowledge, the most extensive reference framework so far. Moreover, we have discovered unexpected erythrocytes-like cardiomyocyte-terminal cardiomyocytes, comprising more than a third of all the cardiomyocytes. Only a few genes are highly expressed in these cardiomyocytes. They are highly differentiated cardiomyocytes function as contraction pump. In addition, we have identified two cardiomyocyte-like conducting cells, lending support to the theory that the sinoatrial node pacemaker cells are specialized cardiomyocytes. Furthermore, we provide an initial blueprint for comprehensive interactions between cardiomyocytes and other cardiac cells. We linked specific cell types to adverse drug reactions and congenital heart diseases and analyzed the roles of cell subtypes in adverse drug reactions and cardiac diseases. These mouse cardiac cell atlas improves our understanding of the heart and provides a valuable reference in response to varying physiological conditions and diseases.
Spice mapping profile in Indonesian traditional side dishes and beverages
Authors: Fibri Dwi Larasatie Nur , Anjani Diva Mahsa , Maymunah Maymunah , Putro Andika Wicaksono , Muhammad Dimas Rahadian Aji 
Published: September 2022

Abstract
Indonesia is well-known for its diversity of culture, ethnicity, agricultural products and cuisine, including staple food, side dishes, snacks and beverages. This study aims to determine the profile of Indonesian traditional side dishes through the pattern of use between culinary areas, the variety of spices, cooking ingredients and cooking methods. In addition, the pattern of spices in Indonesian beverages, their categories, and the relationship among the uses of the spices are part of interest. The research was conducted by extracting secondary data from the Indonesian Culinary Database in the form of a matrix diagram. The obtained data were tested with Principal Component Analysis (PCA) method with the help of XLSTAT software in order to reduce the magnitude of the observed data dimensions without losing significant information illustrating the actual data. This research concluded that every culinary area had a significant correlation with the specific spice and ingredients and a positive correlation between one spice and another. This information can be a solid basis for product development and an essential strategy for introducing new products to be more readily accepted.
Research Notes: Harnessing the nutritional benefits of pineapple pulp fiber to enhance antioxidant potential of wheat flour
Authors: Okoboi Joash , Kakongi Nathan , Male Keneth , Aja Patrick M , Tusubira Deusdedit , Kagoro-Rugunda Grace 
Published: September 2022

Abstract
Pineapple pulp fiber is highly palatable but is usually wasted during the processing of pineapple juice resulting in a loss in the pineapple value chain. It is known to contain both soluble and insoluble dietary fiber, antioxidants, vitamins, bromelain, and many important minerals. Changing lifestyles associated with most western diets characterized by excess intake of calories has led to increased incidence of type 2 diabetes mellitus in Africa. Moreover, hyperglycemia in diabetes mellitus is linked to increased generation of reactive oxygen species (ROS) leading to oxidative stress. ROS are known to damage cellular macromolecules including oxidation of lipids and nucleic acids. The need to formulate dietary formulas to achieve both reductions of calories with enhanced antioxidant potential inspired us to design a wheat flour-based formula enriched with pineapple pulp fiber of up to 10% of its weight. Pineapple pulp fiber-enriched wheat flour positively impacts the pineapple value chain. This study aimed at determining the antioxidant potential of the pineple pulp fibre enriched wheat flour. Pineapple pulp fiber-enriched wheat flour was prepared by mixing 10 g of dry and milled pineapple pulp with 90g of all-purpose wheat flour. The total polyphenolic content, total flavonoid content, and ferric reducing antioxidant power of the enriched and non-enriched wheat flour were determined using spectrophotometric method. The results were statistically analysedusing t-tests at a p < 0.05 level of significance. Enrichment of wheat flour with pineapple pulp fiber significantly increased the total polyphenolic content (p = 0.001), total flavonoids content (p = 0.002), and Ferric Reducing Antioxidant Power (FRAP) (p = 0.001) of the flour. These results indicate that pineapple pulp fiber has a potential to enhancing the nutritional quality of wheat flour through added antioxidant properties.
Rip Current Mortality in the Coastal Zone of the United States and Its Territories: 2000-2020
Authors: Dixon Richard Waynw 
Published: September 2022

Abstract
Rip currents are the primary cause of surf zone mortality in the US. This study examines mortality reports for 2000-2020 as compiled by the National Weather Service. Analysis includes demographic, spatial, and temporal distributions. Results of the analysis may be used to identify specific locations, timeframes, and populations adversely affected by this hazard. Such information may be used to tailor warnings and safety information to those populations most at risk.
Developing a dynamic geofencing algorithm for HVTT cargo security in road transport
Authors: Kuna Jakub , Czerwiński Dariusz , Janicki Wojciech , Filipek Piotr 
Published: September 2022

Abstract
Cargo security is one of the most critical issues in modern logistics. For high-value theft-targeted (HVTT) cargo the driving phase of transportation takes up a major part of thefts. Dozen fleet management solutions based on GNSS positioning were introduced in recent years. Existing tracking solutions barely meet the requirements of TAPA 2020. Map-matching algorithms present valuable ideas on handling GNSS inaccuracy, however, universal map-matching methods are overcomplicated and not suitable for real-time implementation. The dynamic geofencing algorithm presented in this article was developed for the specific purpose of HVTT security. The algorithm is adaptive geometric-based matching (alternately curve-to-curve, point-to-curve, point-to-point). The idea behind the algorithm is to detect and eliminate the atypical matching circumstances - namely if the raw position is registered at one of the exceptions described in the paper. The problem of adaptive cartographic projection is also addressed. The practical value of the proposed algorithm is that the distance between the raw GNSS position and map-matched position can be used as a quantitative security factor. Further development works focus on reducing false alarms caused by GNSS inaccuracy and drift.
Simultaneous Determination of Neonicotinoid Insecticides and Metabolites Residues in Milk and Infant Formula Milk Powder by EMR-Liquid Chromatography-Tandem Mass Spectrometry
Authors: Hou Jianbo , Xie Wen , Qian Yan , Zhang Wenhua , Shi Yingzhu , Song Wei , Lou Chengjie 
Published: September 2022

Abstract

An analytical method based on Enhanced Matrix Removal Lipid - Liquid Chromatography - Tandem Mass Spectrometry (EMR-LC-MS/MS) was developed for determination of neonicotinoid insecticides and metabolites residues (Imidacloprid (IMI) and its metabolites Imidacloprid-urea (IMI-U), Imidacloprid-olefin (IMI-O), Acetamiprid (ACE) and its metabolite N-desmethyl acetamiprid (IM 2 − 1), Dinotefuran (DIN) and its metabolite [1-methy1-3(tetrahydro-3-furylmethy1) urea (DIN-UF), Thiacloprid (THIA), Thiamethoxam (TMX), Clothianidin (CLO, metabolite of thiamethoxam), and Flupyradifurone (FLU)) in milk and infant formula milk powder. In this method, samples were added with extraction kits (containing sodium chloride, anhydrous magnesium sulfate, sodium citrate and sodium hydrogencitrate sesquinydrat), and acetonitrile was used for the protein precipitation and extraction, and then cleaned up by EMR, detected by LC-MS/MS with multiple reaction monitoring (MRM) mode under positive electrospray ionization (ESI+), the isotope dilution internal standard or external standard method were used for quantification. The limits of quantification (LOQs, S/N = 10) were 2 µg/kg (IMI, IMI-U, ACE, IM 2 − 1, DIN-UF, THIA and TMX) and 5 µg/kg (IMI-O, DIN, CLO and FLU) for milk; 2 µg/kg (ACE), 15 µg/kg (THIA, IM 2 − 1, DIN-UF, THIA and TMX) and 40 µg/kg (IMI-U, IMI-O, DIN, CLO and FLU) for infant formula milk powder. The five levels calibration curves were used for quantification (0 µg/kg, 5 µg/kg, 10 µg/kg, 50 µg/kg, 100 µg/kg for milk and 0 µg/kg, 40 µg/kg, 80 µg/kg, 400 µg/kg, 800 µg/kg for infant formula milk powder), the correlation coefficients of linear calibration curve were higher than 0.995. At three spiked levels of 5, 10, 50 µg/kg (milk), or 40, 80, 400 µg/kg (infant formula milk powder), the recoveries were in the range of 71.7–108.7% and 71.9%-107.1%, the relative standard deviations were below 12.6% and 13.9%, respectively. This method was simple, rapid, and accurate to determinate the neonicotinoids and their metabolites residues in milk and infant formula milk powder.
Surgical efficacy evaluation of a modified Melbourne method in treatment of sagittal synostosis
Authors: Yan Qing , Zheng Lei , Qiu Dezhi , Zhang Xianli , Huang Songming , Gao Zhe , Wang Gang 
Published: September 2022

Abstract
Purpose To evaluate the efficacy of a modified Melbourne surgery technique in the treatment of pediatric sagittal synostosis in Chinese population.
Methods Thirty-seven sagittal synostosis patients who received surgery in the Children’s Hospital of Nanjing Medical University, Department of Neurosurgery, from January 2015 to January 2020 were analyzed in this study. Here we reconstruct patients’ CT scan images from pre- and post-operation and control groups. Then the data of ICV, CI, anterior skull height, posterior skull height, and biparietal diameter were analyzed using the paired t-test or Wilcoxon matched-pairs signed-ranks test.
Result The age of these patients was 28.33±11.54 months. After surgery, in the modified group, the average ICV was enlarged from 1280.95±136.06 to 1431.79±138.17 cm3 (P<0.001), the average CI was increased from 0.70±0.05 to 0.79±0.03 (P<0.001). The average anterior skull height, posterior skull height, and biparietal diameter were change from 99.39±4.52 mm, 83.96±5.97 mm, and 111.67±9.48 mm to 87.89±3.81 mm, 107.47±8.61 mm, and 134.15±7.18 mm after surgery (P<0.001, P=0.03, P<0.001, respectively). The average anterior tilt angle and posterior tilt angle were change from 33.75±3.94° and 25.73±5.25° to 16.56±3.59° and 14.14±3.45° after surgery (P<0.001, P<0.001, respectively).
Conclusion The modified Melbourne method is a safe and effective surgical method to treat older children or children with severe sagittal synostosis.
Acute impact of the early application of alirocumab on lipoprotein (a) and interleukin-6 in patients with unstable angina pectoris: a retrospective before-after study
Authors: Xu Zhen Yu , Zhang Lu Lu , Wang Sheng Huang , Wang Yong 
Published: September 2022

Abstract

BackgroundLipoprotein (a) is a determined causal risk factor for residual risks of recurrent ischemic cardiovascular events. Alirocumab has been found to reduce lipoprotein (a) levels. However, its effects on lipoprotein (a) and inflammation marker in a Chinese population with unstable angina remain to be characterized.AimWe aimed to assess the effect of alirocumab on lipoprotein (a) and inflammatory marker in Chinese subjects with unstable angina.MethodIn aretrospective before-after study, lipoprotein (a), interleukin-6 and other lipid profiles were measured before and after 4 weeks of alirocumab treatment in 53 patients with unstable angina (UA) who had already received oral lipid-lowering therapies.ResultsThe alirocumab signiﬁcantly lowered the levels of lipoprotein (a) (−11.28 mg/dL;p< 0.001) and interleukin-6 (-1.65 pg/mL;p< 0.001) after treatment. Moreover, there was a positive linear correlation between lipoprotein (a) and interleukin-6 at baseline (R=0.86;p< 0.001). Furthermore, in 11 patients with lipoprotein (a) levels ≥ 50 mg/dL at baseline, lipoprotein (a) (-27.37 mg/dL;p< 0.001) and interleukin-6 (-2.97 pg/mL;p< 0.001) decreased after treatment. In 42 patients with lipoprotein (a) levels < 50 mg/dL at baseline, lipoprotein (a) (-7.07 mg/dL;p= 0.001) and interleukin-6 (-1.31pg/mL,p< 0.001) also decreased after treatment.ConclusionsEarly application of alirocumab may be effective in reducing the levels of lipoprotein (a) and interleukin-6 in Chinese patients with unstable angina in the short term, especially in patients with lipoprotein (a) ≥ 50 mg/dL.
Tell me What you Like: Introducing Natural Language Preference Elicitation Strategies in a Virtual Assistant for the Movie Domain
Authors: Musto Cataldo , Martina Alessandro Francesco Maria , Iovine Andrea , Narducci Fedelucio , de Gemmis Marco , Semeraro Giovanni 
Published: September 2022

Abstract

Preference elicitation is a crucial step for every recommendation algorithm. Traditional interaction strategies for eliciting users’ interests and needs range from button-based interfaces, where users have to select what they like among a set of fixed alternatives, to more recent conversational interfaces, where users have to reply to some questions formulated by the algorithm about their preferences. However, none of these strategies either mimics the dynamics of real-world open-ended interactions, or allows users to express their needs with an adequate level of expressiveness and control. In this paper, we present a strategy that allow users to express their preferences and needs through natural language statements. In particular, our natural language preference elicitation pipeline allows users to express preferences on objective movie features (e.g., actors, directors, etc.) that are extracted from a structured knowledge base, as well as on subjective features that are collected by mining user-written movie reviews.
To validate our claims, we carried out a user study in the movie domain (N = 249). The main finding of our experiment is that users tend to express their preferences by using objective features, whose usage largely overcomes that of subjective features, that are more complicated to be expressed. However, the combination of objective and subjective features often leads to better recommendations, at the cost of a slightly longer conversation. We have also identified the main challenges that arise when users talk to the virtual assistant by using subjective features, and this paves the way for future developments of our methodology.