bluuebunny/crossref_metadata_2025_split huggingface dataset:
Beyond 1,2,3-triazoles: Formation and Applications of Ketemines Derived
from Copper Catalyzed Azide Alkyne Cycloaddition
Authors: Escandón-Mancilla Flor M. , González-Rivas Nelly , Basavanag Unnamatla Murali V. , García-Eleno Marco A. , Corona-Becerril David , Frontana-Uribe Bernardo A. , Cuevas-Yañez Erick 
Published: September 2022

Abstract:
Ketemines represent an interesting class of organic intermediates that has undergone a regrowth
as a consequence of recent extensions of copper catalyzed azide alkyne cycloaddition (Cu-
AAC) to other synthetic fields. This review summarizes the most recent generation methods of
ketimines from CuAAC reaction, highlighting chemical properties focused on the synthesis of cyclic
compounds, among others, affording a general outlook towards the development of new biologically
active compounds.
Neutrophil Elastase in the Pathogenesis of Chronic Obstructive Pulmonary
Disease: A Review
Authors: Rosyid Alfian Nur , Saputra Pandit Bagus Tri , Purwati Dinda Dwi , Ulhaq Alyaa Ulaa Dhiya , Yolanda Sherly , Djatioetomo Yovita Citra Eka Dewi , Bakhtiar Arief 
Published: September 2022

Abstract:
Chronic obstructive pulmonary disease (COPD) is one of the leading causes of mortality
globally. It is associated with a low quality of life and socio-economic burden. Airway destruction
in COPD pathogenesis is primarily due to the three mechanisms: protease-antiprotease imbalance,
chronic airway inflammation, and oxidative stress, which is triggered by exposure to harmful particles, such as cigarette smoking. Neutrophil elastase (NE), a serine protease stored in azurophilic
granules of neutrophils, actively participates in airway remodeling and microbiocidal activity. It hydrolyzes elastin, collagen, and other vital extracellular matrix proteins (EMP) in the respiratory tissue. In addition, neutrophil elastase activates other principal proteinases such as matrix metalloprotease (MMP)-2, MMP-9, Cathepsin B, Meprin α protease, and Calpain that amplify EMP degradation. Macrophage, the primary leukocyte, responsible for lung parenchymal inflammation in COPD,
is also activated by NE. However, neutrophil elastase level is positively correlated with the degree
of airway inflammation and disease severity. Neutrophil elastase activates reactive oxygengenerating systems such as nicotinamide adenine dinucleotide phosphate (NADPH) oxidase and
myeloperoxidase and it also generates mitochondrial-derived-reactive oxygen species formation by
inducing the secretion of Interleukin (IL)-1 andTumour necrosis factor (TNF)- α. In addition, neutrophil elastase stimulates respiratory cell apoptosis by direct (e.g., activating the caspase-3 pathway) and indirect mechanisms (e.g., by secretion of Neutrophil Extracellular Traps). Surprisingly,
neutrophil elastase may have small anti-inflammatory properties. In conclusion, neutrophil elastase
is one of the main culprits responsible for COPD pathogenesis by mediating the activation of Triad
COPD pathogenesis.
Coexistence of Non-Hodgkin's Lymphoma and Acute Myeloid Leukemia at Initial Diagnosis: A Case Report
Authors: Ke Meng Meng , Wang Zhi Zhong , Wan Qin , Chen Zhi Jun 
Published: September 2022

:Non-Hodgkin's lymphoma and acute myeloid leukemia are both hematological malignancies that rarely coexist at the time of initial diagnosis. We present a case of non-Hodgkin lymphoma and acute myeloid leukemia diagnosed on the first admission.Background:Lymphoma and leukemia, both malignant hematological cancers, are primarily separate diseases, with a majority of cases originating independently. The co-occurrence of lymphoma and leukemia at the time of the first diagnosis is extremely rare, and few relevant reports exist in the medical literature. We describe a case of a patient with non-Hodgkin's lymphoma and acute myeloid leukemia, a very rare occurrence.Case Report:A 57-year-old man complained of fatigue and neck tumors. A physical examination revealed several enlarged superficial lymph nodes throughout the body. On admission, routine blood tests revealed anemia, thrombocytopenia, and normal counts of white blood cells. Cytology of two cervical lymph nodes indicated non- Hodgkin's lymphoma, 18F-PET/CT: multiple enlarged lymph nodes with hypermetabolism, diffuse hypermetabolism of the bone marrow, suggesting lymphoma infiltration in the bone marrow, and a bone marrow biopsy revealed acute myeloid leukemia. Ultimately, the patient was diagnosed with non-Hodgkin’s lymphoma and acute myeloid leukemia.Conclusion:Primary bilineage hematological malignancies are rare, and the mechanism underlying their incidence is unknown. Infiltration of the bone marrow by lymphoma or leukemia can result in diffuse hypermetabolism, which is mostly diagnosed via bone marrow biopsy.
Isatin Conjugates as Antibacterial Agents: A Brief Review
Authors: Hassan Firoj , Azad Iqbal , Asif Mohd , Shukla Deepanjali , Husain Atif , Khan Abdul Rahman , Saquib Mohammad , Nasibullah Malik 
Published: September 2022

Abstract:
Pathogenic bacteria, with their innate resistance to drugs, pose a constant threat to human
health and well-being and put a persistent strain on the health care system. Development of more
effective and safer novel antibacterial drugs is warranted to counter the menace unleashed by pathogenic
bacteria. Integration of privileged pharmacophores from various bioactive molecules into a
single template is a promising strategy to obtain new leads with unique mechanisms of action to
overcome drug resistance. In the past few years, numerous isatin-based hybrid molecules were
screened and their pharmacological properties were explored in efforts to develop novel therapeutics.
The results of screening show that isatin conjugates exhibit promising activity against a broad range
of highly pathogenic gram-positive and gram-negative bacteria and can serve as important leads in
the discovery of highly potent broad spectrum antibacterial drugs. Herein, we review the antibacterial
bioactive profile of a variety of hybrid isatin derivatives, including isatin–azole, isatin-quinoline/
quinolone, isatin-furan/coumarin, isatin-hydrazone/(thio)semicarbazone, isatin dimers, and isatin–
indole hybrids.
Mechanical Performance and Durability of Date Palm Fibers Repair Mortar
Authors: Yahiaoui Walid , Kenai Abdelraouf , Menadi Belkacem , Kenai Said 
Published: September 2022

Background:
Concrete is the most widely used material in the world after water. However, concrete could be damaged under aggressive environments and many concrete structures require repair and frequent maintenance. Readymade mortars with and without synthetic fibers such as polypropylene and acrylic are often used as repair mortars. The partial replacement of cement by supplementary cementitious materials and the use of alternative fibers such as natural and agro-waste fibers could reduce the environmental impact of readymade mortars.

Methods:
This paper presents a comparative study between the performance of laboratory made and ready-made repair mortars. The laboratory repair mortars were based on date palm fibers and local mineral additions (slag and natural pozzolan). The volume ratio of date palm fibers addition was 0.75% and mineral additions content were fixed at 15% as cement replacement. Compressive strength, flexural strength, shrinkage and the bond strength by slant shear test and tensile strength of concrete by the pull-off method were investigated. The durability of the mortar was evaluated by water capillary absorption.

Results:
The results indicated that the addition of natural fibers and the substitution of cement by 15% of mineral additions improves the flexural strength but reduces the compressive strength of the fiber-reinforced repair mortar. The lowest values of total shrinkage, water capillary absorption and sorptivity were observed for repair mortars based on acrylic fibers compared to repair mortars with natural vegetables fibers.

Conclusion:
The mechanical and durability performances of laboratory made repair mortars were comparable to those of readymade mortars.
Knowledge and Skill Needs in E-course Training of an Expanded Program for Immunization Staff in Thailand: A Mixed-method Design
Authors: Rutchanagul Pregamol , Sangnimitchaikul Wipada 
Published: September 2022

Background:
This study was conducted to examine essential content needs in E-course training to improve the knowledge and skills of immunization staff members in Thailand.

Methods:
This study used a mixed-method research design. Quantitative methodology was used to study 449 staff members of government care facilities in the Expanded Program on Immunization (EPI). Surveys were conducted by using the perceived needs for immunization training questionnaire. Qualitative methodology employed in-depth interview guidelines on immunization content that were used to interview 14 staff members at EPI. The quantitative data were analyzed by using descriptive statistics and one-way analysis of variance (ANOVA). Interview data were analyzed in content analysis.

Results:
The participants were immunization staff members of three positions: registered nurses, pharmacists and public health technical officers. The participants had different E-course training content needs concerning vaccine-report registration, administering the vaccines and dealing with adverse events following immunization (AEFI) with a statistical significance of .05. This was consistent with the findings from in-depth interviews, which showed staff members had both varying and connected work responsibilities, giving members from all three groups a need for the same basic knowledge pertaining to immunization. In some aspects, staff members required different training content details depending on job descriptions. Public health technical officers were found to require details on vaccine-report registration. Nurses required knowledge dealing with AEFI and administering the vaccines. Pharmacists needed details on the cold-chain system the most.

Conclusion:
Executives at the policy level should specify essential content requiring development for each position in addition to designing training models to meet the needs of EPI staff, enabling access and promoting effective use.
Evaluation of Knowledge, Attitude, and Protective Behaviors of Teachers Against Dust Phenomenon Based on the Health Belief Model
Authors: Sarani Mohammad , Heydari Azadeh , Zare Seyedeh Mahboubeh Hosseini , Hosseini-Zare Maryam Sadat , Bazi Mohammad Abbas Zadeh , Sarani Najmeh , Isfahani Parvaneh 
Published: September 2022

Background:Awareness of protective behaviors against haze plays an important role in disease prevention and control. Students, who are in turn educated by teachers, are one of the important groups that can transfer health-related concepts to families. Therefore, this study aimed to evaluate teachers' knowledge, attitudes, and behavior regarding adopting healthy behaviors upon exposure to haze using the health belief model (HBM).Materials and Methods:This descriptive-analytical (cross-sectional) study was performed on 250 primary school teachers from Zabol County by cluster sampling. Data were gathered by multi-section questionnaires. Its validity and reliability have been evaluated. The data were analyzed in SPSS software (version 21) using proper statistical tests at a significance level of P < 0.05.Results:Teachers were in the average age range of 38.66±6.81 years. Mean scores of behavior, perceived susceptibility, perceived severity, perceived benefits, perceived barriers, and self-efficacy were obtained as 11.88±2.47, 26.42±43.10, 26.42±4.10, 22.43±4.10, 28.26±5.12, 10.73±2.06, respectively. There was a significant relationship between awareness and protective behavior (r= 0.61, P=0.0012). Health belief model constructs were able to predict about 39.8% of the variance of protective behavior, with the level of Education (B = 0.369) being the strongest predictor.Conclusion:Results show that the design and implementation of educational programs based on the HBM in schools are effective in the promotion of awareness and empowerment with the aim of increasing protective behavior in teachers in the face of the haze phenomenon.
MicroRNA-Mediated Regulation of BMP Signaling in the Developing
Neural Tube
Authors: Greene Robert M. , Mukhopadhyay Partha , Seelan Ratnam S. , Pisano M. Michele 
Published: September 2022

Background:
Neural tube (NT) morphogenesis is reliant on the proper temporospatial
expression of numerous genes and synchronized crosstalk between diverse signaling cascades and
gene regulatory networks governing key cellular processes. MicroRNAs (miRNAs), a group of
small non-coding regulatory RNAs, execute defining roles in directing key canonical pathways during
embryogenesis.

Objective:
In order to comprehend the mechanistic underpinnings of miRNA regulation of NT morphogenesis,
we have identified in the current study various miRNAs and their target mRNAs associated
with BMP signaling during critical stages of neurulation.

Methods:
We previously demonstrated the expression of several miRNAs during the critical stages
of neurulation (gestational days (GD) 8.5, 9.0, and 9.5) employing high-sensitivity, high-coverage
microarrays. In the present study, bioinformatic analyses were used to identify miRNAs differentially
expressed (DE) in the embryonic NT that target messenger RNAs (mRNAs) associated with the
bone morphogenetic protein (BMP) signaling pathway. RNAs extracted from the developing NT
were hybridized to both miRNA and mRNA arrays to evaluate miRNA-mRNA interactions.

Results:
Bioinformatic analysis identified several DE miRNAs that targeted mRNAs encoding
members of (and proteins associated with) the BMP signaling pathway – a signaling cascade central
to normal NT development.

Conclusion:
Identification of the miRNAs and their mRNA targets associated with BMP signaling
facilitates a better understanding of the crucial epigenetic mechanisms underlying normal NT development
as well as the pathogenesis of NT defects. The current study supports the notion that miRNAs
function as key regulators of neural tube morphogenesis via modulation of the BMP signaling
cascade. Altered expression of these miRNAs during neurulation may therefore result in NT defects.
Biomedical Applications of Polysaccharide-Based Aerogels: A Review
Authors: Warrier Sreelakshmi K. , Mathew Shilpa Sarah , Pothan Laly A. , Ajish Koottumpurath Raghavan 
Published: September 2022

Abstract:Aerogels, in recent times, have become materials of extensive research due to their fascinating capabilities in different fields. High porosity, large surface area, low thermal conductivity and low density make them significant in fields such as medicine, environmental engineering, food packaging, and so on. Biodegradability, low toxicity and biocompatibility, in addition to the aforementioned properties, offered by bio-based aerogels, especially polysaccharide based aerogels, give them a huge advantage over conventional inorganic ones. Polysaccharide based aerogels synthesised from starch, cellulose, pectin, alginate, chitosan, carrageenan and agarose precursors enable sustainable developments in the biomedical, cosmetic, electronic, construction and food industries. This review focuses on the biomedical applications of polysaccharide based aerogels, with special emphasis on its implications in drug delivery, tissue engineering, medical implantable devices, wound dressing, biosensors and bio-imaging. The future perspectives of these smart materials have also been subjected to discussion.
A clinical review: schizophrenia, transsexualism or their combination?
Authors: Soldatkin V. A. 
Published: September 2022

The change in the position of transsexualism in the new ICD classification, the hot debate about the psychopathological structure of this phenomenon and its relation to other mental disorders determine the relevance of considering the following clinical case.A detailed clinical description demonstrates the possibility of combining two initially independent disorders - transsexualism and schizophrenia - which gave a bright individual color to the clinical picture and caused difficulties both in the medical and legal aspects of patient care.At the age of 25, a patient with clinical signs of transsexualism developed acute paraphrenia psychosis. Without medical assistance, according to the mechanisms of sanogenesis, the severity of the condition decreased, but the psychotic state was not recovered. Features of the onset and dynamics of psychosis typical for the continuous type of paranoid schizophrenia (acuteness of development and absence of signs of syndromotaxis) allow us to attribute it to episodic with progressive or stable deficit paranoid schizophrenia variant. It is noteworthy that after the onset of psychosis, the stereotype of the development of birth-assigned gender rejection syndrome did not undergo significant changes: the formation of crossdressing, inverse psychosexual identity and inverse gender identity were finally completed; mimicry reactions became bright, self-destructive tendencies began to appear more and more clearly, and the patient applied for permission to change gender.In the described clinical situation, the primary task is to overcome the acute schizophrenia psychosis. After solving this problem, the secondary prevention and rehabilitation program development becomes more important. Formally, the patient does not have the right to change sex, since she suffers from schizophrenia, which is a contraindication for sex transformation. In the state of psychosis, the patient essentially loses her civil procedural capacity. Informally, the question remains relevant.
Association Between Mobile Health App Engagement and Weight Loss and Glycemic Control in Adults With Type 2 Diabetes and Prediabetes (D’LITE Study): Prospective Cohort Study
Authors: Lim Su Lin , Tay Melissa Hui Juan , Ong Kai Wen , Johal Jolyn , Yap Qai Ven , Chan Yiong Huak , Yeo Genevieve Kai Ning , Khoo Chin Meng , Yaxley Alison 
Published: September 2022

Background
Mobile health apps are increasingly used as early intervention to support behavior change for diabetes prevention and control, with the overarching goal of lowering the overall disease burden.

Objective
This prospective cohort study conducted in Singapore aimed to investigate app engagement features and their association with weight loss and improved glycemic control among adults with diabetes and prediabetes from the intervention arm of the Diabetes Lifestyle Intervention using Technology Empowerment randomized controlled trial.

Methods
Diabetes and prediabetes participants (N=171) with a median age of 52 years, BMI of 29.3 kg/m2, and glycated hemoglobin (HbA1c) level of 6.5% and who were being assigned the Nutritionist Buddy Diabetes app were included. Body weight and HbA1c were measured at baseline, 3 months, and 6 months. A total of 476,300 data points on daily app engagement were tracked via the backend dashboard and developer’s report. The app engagement data were analyzed by quartiles and weekly means expressed in days per week. Linear mixed model analysis was used to determine the associations between the app engagements with percentage weight and HbA1c change.

Results
The median overall app engagement rate was maintained above 90% at 6 months. Participants who were actively engaged in ≥5 app features were associated with the greatest overall weight reduction of 10.6% from baseline (mean difference −6, 95% CI −8.9 to −3.2; P<.001) at 6 months. Adhering to the carbohydrate limit of >5.9 days per week and choosing healthier food options for >4.3 days per week had the most impact, eliciting weight loss of 9.1% (mean difference −5.2, 95% CI −8.2 to −2.2; P=.001) and 8.8% (mean difference −4.2, 95% CI −7.1 to −1.3; P=.005), respectively. Among the participants with diabetes, those who had a complete meal log for >5.1 days per week or kept within their carbohydrate limit for >5.9 days per week each achieved greater HbA1c reductions of 1.2% (SD 1.3%; SD 1.5%), as compared with 0.2% (SD 1%; SD 0.6%). in the reference groups who used the features <1.1 or ≤2.5 days per week, respectively.

Conclusions
Higher app engagement led to greater weight loss and HbA1c reduction among adults with overweight or obesity with type 2 diabetes or prediabetes.

Trial Registration
Australian New Zealand Clinical Trials Registry (ANZCTR) ACTRN12617001112358; https://anzctr.org.au/Trial/Registration/TrialReview.aspx?ACTRN=12617001112358
Effectiveness of an App-Based Short Intervention to Improve Sleep: Randomized Controlled Trial
Authors: Vollert Bianka , Müller Luise , Jacobi Corinna , Trockel Mickey , Beintner Ina 
Published: September 2022

Background
A growing body of evidence for digital interventions to improve sleep shows promising effects. The interventions investigated so far have been primarily web-based; however, app-based interventions may reach a wider audience and be more suitable for daily use.

Objective
This study aims to evaluate the intervention effects, adherence, and acceptance of an unguided app-based intervention for individuals who wish to improve their sleep.

Methods
In a randomized controlled trial, we evaluated the effects of an app-based short intervention (Refresh) to improve sleep compared with a waitlist condition. Refresh is an 8-week unguided intervention covering the principles of cognitive behavioral therapy for insomnia (CBT-I) and including a sleep diary. The primary outcome was sleep quality (insomnia symptoms) as self-assessed by the Regensburg Insomnia Scale (RIS). The secondary outcomes were depression (9-item Patient Health Questionnaire [PHQ-9] score) and perceived insomnia-related impairment.

Results
We included 371 participants, of which 245 reported poor sleep at baseline. About 1 in 3 participants who were allocated to the intervention group never accessed the intervention. Active participants completed on average 4 out of 8 chapters. Retention rates were 67.4% (n=250) at postassessment and 57.7% (n=214) at the 6-month follow-up. At postintervention, insomnia symptoms in the intervention group had improved more than those in the waitlist group, with a small effect (d=0.26) in the whole sample and a medium effect (d=0.45) in the subgroup with poor sleep. Effects in the intervention group were maintained at follow-up. Perceived insomnia-related impairment also improved from pre- to postassessment. No significant intervention effect on depression was detected. Working alliance and acceptance were moderate to good.

Conclusions
An app-based, unguided intervention is a feasible and effective option to scale-up CBT-I-based treatment, but intervention uptake and adherence need to be carefully addressed.

Trial Registration
ISRCTN Registry ISRCTN53553517; https://www.isrctn.com/ISRCTN53553517