bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nonlinear dispersion relation in integrable turbulence
Authors: Tikan Alexey , Bonnefoy Félicien , Ducrozet Guillaume , Prabhudesai Gaurav , Michel Guillaume , Cazaubiel Annette , Falcon Éric , Copie Francois , Randoux Stéphane , Suret Pierre 
Published: June 2022

AbstractWe investigate numerically and experimentally the concept of nonlinear dispersion relation (NDR) in the context of partially coherent waves propagating in a one-dimensional water tank. The nonlinear random waves have a narrow-bandwidth Fourier spectrum and are described at leading order by the one-dimensional nonlinear Schrödinger equation. The problem is considered in the framework of integrable turbulence in which solitons play a key role. By using a limited number of wave gauges, we accurately measure the NDR of the slowly varying envelope of the deep-water waves. This enables the precise characterization of the frequency shift and the broadening of the NDR while also revealing the presence of solitons. Moreover, our analysis shows that the shape and the broadening of the NDR provides signatures of the deviation from integrable turbulence that is induced by high order effects in experiments. We also compare our experimental observations with numerical simulations of Dysthe and of Euler equations.
Research on the visual image-based complexity perception method of autonomous navigation scenes for unmanned surface vehicles
Authors: Shi Binghua , Guo Jia , Wang Chen , Su Yixin , Di Yi , AbouOmar Mahmoud S. 
Published: June 2022

AbstractTo solve the long-tail problem and improve the testing efficiency for autonomous navigation systems of unmanned surface vehicles (USVs), a visual image-based navigation scene complexity perception method is proposed. In this paper, we intend to accurately construct a mathematical model between navigation scene complexity and visual features from the analysis and processing of image textures. First, the typical complex elements are summarized, and the navigation scenes are divided into four levels according to whether they contain these typical elements. Second, the textural features are extracted using the gray level cogeneration matrix (GLCM) and Tamura coarseness, which are applied to construct the feature vectors of the navigation scenes. Furthermore, a novel paired bare bone particle swarm clustering (PBBPSC) method is proposed to classify the levels of complexity, and the exact value of the navigation scene complexity is calculated using the clustering result and an interval mapping method. By comparing different methods on the classical and self-collected datasets, the experimental results show that our proposed complexity perception method can not only better describe the level of complexity of navigation scenes but also obtain more accurate complexity values.
Magnified endoscopy with texture and color enhanced imaging with indigo carmine for superficial nonampullary duodenal tumor: a pilot study
Authors: Okimoto Kenichiro , Matsumura Tomoaki , Maruoka Daisuke , Kurosugi Akane , Shiratori Wataru , Nagashima Ariki , Ishikawa Tsubasa , Kaneko Tatsuya , Kanayama Kengo , Akizue Naoki , Ohta Yuki , Taida Takashi , Saito Keiko , Kato Jun , Kato Naoya 
Published: June 2022

AbstractThis pilot study aimed to investigate the utility of texture and color enhancement imaging (TXI) with magnified endoscopy (ME) for the preoperative diagnosis of superficial nonampullary duodenal epithelial tumors (SNADETs). We prospectively evaluated 12 SNADETs. The visibility for ME-TXI, ME with indigo carmine (ICME)—white-light imaging (WLI), ICME-TXI compared to ME-NBI (narrow-band imaging) was scored (+ 2 to − 2 ME-NBI was set as score 0) by 3 experts. Scores + 2 and + 1 were defined as improved visibility. The intra-observer and interobserver agreement for improved visibility of surface structure (SS) was evaluated. Sensitivity, specificity, and positive predictive value (PPV) for Vienna Classification (VCL) C4/5 associated with the preoperative diagnosis of ICME-TXI were analyzed. The SS visibility score of ICME-TXI was significantly higher than that of ME-NBI, ME-TXI, and ICME-WLI (P < 0.001 respectively). The kappa coefficients of reliability for intra-observer and interobserver agreement for the SS visibility improvement with ICME-TXI were 0.96, 1.00, 1.00 and 0.70, 0.96, 0.96 respectively. All endoscopists preferred ICME-TXI for visualizing SS mostly for all lesions. The sensitivity, specificity, and PPV (%) of ICME-TXI for VCL C4/5 were 80, 66.7, and 63.2, respectively. ICME-TXI facilitates the visibility of the SS of SNADETs and may contribute to their preoperative diagnosis.
Incremental diagnostic value of 18F-Fluetemetamol PET in differential diagnoses of Alzheimer’s Disease-related neurodegenerative diseases from an unselected memory clinic cohort
Authors: Bao Yi-Wen , Shea Yat-Fung , Chiu Patrick Ka-Chun , Kwan Joseph S. K. , Chan Felix Hon-Wai , Mak Henry Ka-Fung 
Published: June 2022

AbstractTo evaluate the incremental diagnostic value of 18F-Flutemetamol PET following MRI measurements on an unselected prospective cohort collected from a memory clinic. A total of 84 participants was included in this study. A stepwise study design was performed including initial analysis (based on clinical assessments), interim analysis (revision of initial analysis post-MRI) and final analysis (revision of interim analysis post-18F-Flutemetamol PET). At each time of evaluation, every participant was categorized into SCD, MCI or dementia syndromal group and further into AD-related, non-AD related or non-specific type etiological subgroup. Post 18F-Flutemetamol PET, the significant changes were seen in the syndromal MCI group (57%, p < 0.001) involving the following etiological subgroups: AD-related MCI (57%, p < 0.01) and non-specific MCI (100%, p < 0.0001); and syndromal dementia group (61%, p < 0.0001) consisting of non-specific dementia subgroup (100%, p < 0.0001). In the binary regression model, amyloid status significantly influenced the diagnostic results of interim analysis (p < 0.01). 18F-Flutemetamol PET can have incremental value following MRI measurements, particularly reflected in the change of diagnosis of individuals with unclear etiology and AD-related-suspected patients due to the role in complementing AD-related pathological information.
An adjustment framework for mitigating the impact of rail transit construction on bus operations
Authors: An Qinhe , Ma Jie , Chen Jingxu , Li Wenhao , Wang Yiran 
Published: June 2022

AbstractDuring the construction of rail transit, some road resources are occupied under construction and hence the capacity of affected road sections is reduced. Due to such temporary impact, the low operational efficiency of bus routes when passing these road sections is following suit, which is inevitably detrimental to the short-term traffic conditions and the urban environment. This paper proposes a three-step adjustment framework to actively mitigate the impact of rail transit construction on bus operations. In Step I, a criterion is developed for selecting bus routes significantly affected due to rail transit construction. In Step II, we design a stop-skipping strategy and truncation strategy, and check whether they are opportune to ameliorate the service of each affected bus route. Yet, these two strategies result in a loss of ridership since some previous stops are not served. In Step III, the feeder bus service is further designed to guarantee spatial coverage nearby the construction area. A mixed-integer linear programming model is developed to determine the optimal configuration of the feeder bus service incorporating two strategies. Finally, a case study based on the Sioux-Falls network is carried out to demonstrate that the proposed adjustment framework is conducive to mitigating negative construction effects and reducing costs.
Appraisal of growth inhibitory, biochemical and genotoxic effects of Allyl Isothiocyanate on different developmental stages of Zeugodacus cucurbitae (Coquillett) (Diptera: Tephritidae)
Authors: Singh Sumit , Diksha  , Mahajan Evani , Sohal Satwinder Kaur 
Published: June 2022

AbstractAllyl isothiocyanate (AITC), a glucosinolates’ hydrolytic product, was studied for its anti-insect potential against an economically important, destructive tephritid pest, Zeugodacus cucurbitae (Coquillett). The first, second and third instar maggots of the pest were fed on artificial diets amended with varied concentrations of AITC viz. 5 ppm, 25 ppm, 50 ppm, 100 ppm, 150 ppm and 200 ppm with DMSO (0.5%) as control. Results revealed high larval mortality, alteration of larval period, prolongation of pupal and total developmental periods in all instars of the maggots treated with AITC as compared to controls. Percent pupation and percent adult emergence decreased in all larval instars. Growth indices viz. Larval Growth Index (LGI) and Total Growth Index (TGI) were negatively affected. Anti-nutritional/post ingestive toxicity of AITC was also revealed by the decrease in Food Assimilation (FA) and Mean Relative Growth rate (MRGR) values with respect to control. Profiles of PO (Phenol oxidase) and other detoxifying enzymes including SOD (Superoxide dismutases), CAT (Catalases), GST (Glutathione-S-transferases), EST (Esterases), AKP (Alkaline phosphatases) and ACP (Acid phosphatases) were also significantly influenced. The genotoxic effect of AITC was also evaluated by conducting comet assays at LC30 and LC50. Significant DNA damage in hemocytes was reflected by increase in Tail length (μm), Percent Tail DNA, Tail Moment (TM) and Olive Tail Moment (OTM) as compared to controls. The results indicated high potential of AITC as biopesticide for pest management.
Using random forest to identify longitudinal predictors of health in a 30-year cohort study
Authors: Loef Bette , Wong Albert , Janssen Nicole A. H. , Strak Maciek , Hoekstra Jurriaan , Picavet H. Susan J. , Boshuizen H. C. Hendriek , Verschuren W. M. Monique , Herber Gerrie-Cor M. 
Published: June 2022

AbstractDue to the wealth of exposome data from longitudinal cohort studies that is currently available, the need for methods to adequately analyze these data is growing. We propose an approach in which machine learning is used to identify longitudinal exposome-related predictors of health, and illustrate its potential through an application. Our application involves studying the relation between exposome and self-perceived health based on the 30-year running Doetinchem Cohort Study. Random Forest (RF) was used to identify the strongest predictors due to its favorable prediction performance in prior research. The relation between predictors and outcome was visualized with partial dependence and accumulated local effects plots. To facilitate interpretation, exposures were summarized by expressing them as the average exposure and average trend over time. The RF model’s ability to discriminate poor from good self-perceived health was acceptable (Area-Under-the-Curve = 0.707). Nine exposures from different exposome-related domains were largely responsible for the model’s performance, while 87 exposures seemed to contribute little to the performance. Our approach demonstrates that ML can be interpreted more than widely believed, and can be applied to identify important longitudinal predictors of health over the life course in studies with repeated measures of exposure. The approach is context-independent and broadly applicable.
Photocatalytic activity of ZrO2/TiO2/Fe3O4 ternary nanocomposite for the degradation of naproxen: characterization and optimization using response surface methodology
Authors: Zare Masoud Habibi , Mehrabani-Zeinabad Arjomand 
Published: June 2022

AbstractIn this study, ZrO2, TiO2, and Fe3O4components were synthesized by co-precipitation, sol–gel, and co-precipitation methods, respectively. In addition, solid-state dispersion method was used for synthesizing of ZrO2/TiO2/Fe3O4ternary nanocomposite. The ZrO2/TiO2/Fe3O4nanocomposite was characterized by different techniques including XRD, EDX, SEM, BET, FTIR, XPS, EELS, and Photoluminescence (PL). The FTIR analysis of ZrO2/TiO2/Fe3O4photocatalyst showed strong peaks in the range of 450 to 700 cm−1, which represent stretching vibrations of Zr–O, Ti–O, and Fe–O. The results of FTIR and XRD, XPS analyses and PL spectra confirmed that the solid-state dispersion method produced ZrO2/TiO2/Fe3O4nanocomposites. The EELS analysis confirmed the pure samples of Fe3O4, TiO2and ZrO2. The EDAX analysis showed that the Zr:Ti:Fe atomic ratio was 0.42:2.08:1.00. The specific surface area, pores volume and average pores size of the photocatalyst were obtained 280 m2/g, 0.92 cm3/g, and 42 nm respectively. Furthermore, the performance of ZrO2/TiO2/Fe3O4nanocomposite was evaluated for naproxen removal using the response surface method (RSM). The four parameters such as NPX concentration, time, pH and catalyst concentration was investigated. The point of zero charge of the photocatalyst was 6. The maximum and minimum degradation of naproxen using photocatalyst were 100% (under conditions: NPX concentration = 10 mg/L, time = 90 min, pH = 3 and catalyst concentration = 0.5 g/L) and 66.10% respectively. The stability experiment revealed that the ternary nanocatalyst demonstrates a relatively higher photocatalytic activity after 7 recycles.
The properties of 0.11 keV–344 MeV ion spectra in the inner heliosheath using regularizedκ-distributions
Authors: Scherer K. , Dialynas K. , Fichtner H. , Galli A. , Roussos E. 
Published: June 2022

Context.The shape of the ion energy spectra plays a critical role in determining the ion energetics, the acceleration mechanisms, and the possible sources of different plasma and suprathermal ion populations. The determination of the exact shape of the total particle spectrum provides the necessary means to address the inner heliosheath dynamics. Apart from various modelling efforts, a direct fit to the measured ion spectra for an extended energy range of ∼0.11–344 MeV has not been performed to date.Aims.We use an extended set of combined 0.11–55 keV remotely sensed energetic neutral atoms (ENA) measurements from the Interstellar Boundary Explorer (IBEX-Lo and IBEX-Hi) and the Cassini/Ion and Neutral Camera (INCA), converted to protons, together with ∼28 keV–344 MeV in situ ion measurements from the low-energy charged particle (LECP) and cosmic ray subsystem (CRS) experiments on Voyager 2, over the declining phase of solar cycle 23 (SC23) and the ascending phase of solar cycle 24 (SC24) to study the characteristics of the particle energy spectrum.Methods.We fitted the 0.11 keV–344 MeV composite ion spectra with a set of regularized isotropicκ-distribution functions (RKDs), which allowed us to determine the macroscopic physical properties.Results.We demonstrate that the 2009–2012 composite spectrum that corresponds to the declining phase of SC23 is well fitted by three different RKDs, while the 2013–2016 spectrum, associated with the rise of SC24, can only be approximated with six differentκ-distribution functions.Conclusions.Our results are generally consistent with shock accelerated particles that undergo additional acceleration inside the inner heliosheath. We identify a low-energy transmitted population of particles, a suprathermal reflected population and a very-high-energy component that is modulated by galactic cosmic rays. The 2013–2016 time period is most likely associated with a mixture of particles from SC23 and SC24, which is reflected by the need to employ six RDKs.
Ernährungsförderliche Politikmaßnahmen
– eine Übersicht der Herausforderungen und Möglichkeiten
für Deutschland im internationalen Vergleich
Authors: Geffert Karin , Klinger Carmen , Hebestreit Antje , Rehfuess Eva , von Philipsborn Peter 
Published: June 2022

Zusammenfassung
Ziel der Studie Der Food Environment Policy Index (Food-EPI) gilt als
methodischer Goldstandard für die systematische Erfassung und Bewertung
der politischen Rahmenbedingungen einer gesundheitsförderlichen
Ernährung; er wurde 2020–2021 erstmals in Deutschland
umgesetzt.
Methodik Die Umsetzung des Food-EPI in Deutschland umfasste sieben
Schritte von der systematischen Analyse der Ausgangssituation, über den
Vergleich mit internationalen Best Practice Beispielen bis hin zur
Identifizierung und Priorisierung von Handlungsoptionen. Im vorliegenden Beitrag
werden die Ergebnisse zusammengefasst und im Kontext aktueller politischer
Entwicklungen diskutiert.
Ergebnisse Die Ergebnisse zeigen deutliche Lücken bei der
Umsetzung von Politikmaßnahmen für eine gesunde
Ernährung in Deutschland. Die folgenden prioritären
Reformmaßnahmen wurden identifiziert: eine flächendeckende,
qualitativ hochwertige und gebührenfreie Schul- und Kitaverpflegung;
eine gesundheitsförderliche Mehrwertsteuerreform; eine Herstellerabgabe
auf Süßgetränke; sowie eine effektive, verbindliche
Regulierung von Kinder-Lebensmittelmarketing.
Schlussfolgerung Deutschland bleibt bei der Förderung einer
gesunden Ernährung durch geeignete Politikmaßnahmen deutlich
hinter internationalen Best Practices zurück. Der im November
2021 beschlossene Koalitionsvertrag eröffnet Möglichkeitsfenster
für evidenzinformierte Reformen.
Zeitliche Veränderung der Prävalenz von
Parkinson-Diagnosen in Deutschen Hausarzt- und Neurologischen Praxen von 2010
bis 2019
Authors: Bohlken Jens , Riedel-Heller Steffi , Kramer Antje , Kostev Karel , Schrag Anette 
Published: June 2022

Zusammenfassung
Hintergrund Bis 2040 wird mit einer erheblichen Prävalenzzunahme
der Parkinson-Erkrankung und damit einhergehend mit einer erheblichen Belastung
der Versorgungssysteme gerechnet. Ziel der Studie war es deshalb, eine
Veränderung der Anzahl an Parkinson-Patienten bereits im Zeitraum 2010
bis 2019 in deutschen Haus- und neurologischen Facharztpraxen zu
untersuchen.
Methode Die vorliegende Querschnittstudie basiert auf den Daten von 411
Hausarzt- (HA) und 56 neurologischen Facharzt-Praxen (FA) aus der IQVIA Disease
Analyzer Datenbank. Die Anzahl der etablierten und neu diagnostizierten
Patienten mit Parkinson-Erkrankung wurde in den Jahren 2010 und 2019 mit Alters-
und Geschlechtsstruktur und der Anteil therapierten Patienten
untersucht.Ergebnisse Die Zahl der Parkinson-Patienten
veränderte sich geringfügig zwischen 2010 bis 2019 von 3352
(0,36% aller Patienten) auf 3541 (0,33%) in den HA-Praxen und
von 4976 (3,48%) auf 4826 (3,34%) in den FA-Praxen. Die Anzahl
der neu diagnostizierten Fälle fiel bei den HA-Praxen leicht von 862
(0,09% aller Patienten) auf 836 (0,08%) und bei den FA-Praxen
von 1818 (1,27%) auf 1372 (0,95% aller Patienten). Der Anteil an
Frauen unter allen Parkinson-Erkrankten sank sowohl in HA- und FA- Praxen von
52,0% bzw. 50,2% auf 47,3% bzw. 46,0%. Das
Durchschnittsalter stieg bei den HA-Praxen von 77,1 (SD 10,4) im Jahr 2010 auf
77,7 (SD 9,3) Jahre im Jahr 2019 und in FA-Praxen von 74,6 (SD 9,9) auf 75,8 (SD
9,9) Jahre.
Diskussion Die prognostizierte Zunahme von Parkinson-Patienten in der
ambulanten Versorgung lässt sich für den Zeitraum 2010 bis 2019
nicht bestätigen. Es gab jedoch eine Verschiebung der Altersstruktur zu
höheren Altersgruppen und eine Verringerung des Anteils an Frauen mit
einer Parkinson-Erkrankung. Neben ätiologischen Erklärungen
sollten Besonderheiten des Versorgungssystems und methodische Limitationen
berücksichtigt werden.
Auswirkungen der COVID-19-Pandemie auf das Informationsmanagement und die Therapieadhärenz von substituierten Patienten mit Alpha-1-Antitrypsin-Mangel (AATM)
Authors: Köhnlein Thomas , Wilkens Marion , Eydt Katharina 
Published: June 2022

Zusammenfassung
Einleitung COVID-19 hat sich zu einer weltweiten Bedrohung für die öffentliche Gesundheit entwickelt und wurde im März 2020 von der WHO zur Pandemie erklärt. Das erhöhte Morbiditäts- und Mortalitätsrisiko bei Menschen mit chronischen Erkrankungen, einschließlich Lungenerkrankungen, ist gut dokumentiert. In dieser Studie wurden Patienten mit Alpha1-Antitrypsin-Mangel (AATM) befragt, wie sich die COVID-19-Pandemie auf ihren Alltag, ihr Krankheitserleben und ihre Therapieadhärenz ausgewirkt hat.Im März 2021 wurde ein 19-Fragen umfassender Fragebogen an 420 AATM-Patienten verschickt, die mit einer AAT-Substitutionstherapie behandelt (Prolastin, Alpha-1-Proteinase-Inhibitor [human], Grifols, Barcelona, Spanien) und im deutschen AlphaCare-Patientenprogramm eingeschrieben waren.
Ergebnisse Von 276 ausgewerteten Fragebögen wurde ein AATM bei einer Mehrheit der Befragten (55,9%, 138) bereits 10 Jahre vor der Befragung diagnostiziert, und ein Großteil (93,5%; 231) fühlte sich durch ihren Arzt, AlphaCare und Alpha1 Deutschland ausreichend über die Krankheit informiert. Der überwiegende Teil der Befragten war eher besorgt/sehr besorgt, sich mit COVID-19 zu infizieren. Nur 1,2% der Befragten gaben an, mit SARS-CoV-2 infiziert worden zu sein, das ist weniger als die Infektionsrate in der Allgemeinbevölkerung zum damaligen Zeitpunkt (3,4%). Fast alle Befragten (94,4%) stimmten voll und ganz zu, dass sie ihre sozialen Kontakte aufgrund der Pandemie eingeschränkt hatten. Ein erheblicher Prozentsatz der antwortenden Patienten gab an, dass sie besorgt waren, während eines Besuchs in ihrer Arztpraxis oder Klinik mit COVID-19 infiziert zu werden. In Bezug auf die Therapieadhärenz gaben nur 18 der Befragten an, die Substitutionstherapie mit AAT während der Pandemie abgebrochen zu haben. Die meisten dieser Abbrüche waren aber kurzfristig – einer war dauerhaft.
Schlussfolgerungen Diese Umfrageergebnisse deuten darauf hin, dass AATM-Patienten über die Risiken von COVID-19 und ihre Erkrankung gut informiert sind und Selbstschutzmaßnahmen praktizieren. Dies könnte zu einer COVID-19-Infektionsrate geführt haben, die niedriger ist als in der Allgemeinbevölkerung. Obwohl die Befragten besorgt über eine Exposition gegenüber COVID-19 in ihrer Arztpraxis oder Klinik waren, unterbrachen nur sehr wenige vorübergehend die Therapie.
Renin-Angiotensin-Aldosterone System in Women Using Combined Oral Contraceptive: A Systematic Review
Authors: dos Santos Priscilla Araújo , de Oliveira Alice Miranda , Alves Caroline Queiroz , Souza Filho Clóvis Figueiredo , Ladeia Ana Marice Teixeira , Petto Jefferson 
Published: June 2022

Abstract
Objective To describe the effects of combined oral contraceptives (COC) on the renin-angiotensin-aldosterone system (RAAS).
Data sources This is a systematic review according to the criteria of Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA), registered in PROSPERO under the ID: CRD42020200019. Searches were performed between August 2020 and December 2021, in the following databases: Medline via Pubmed, Cochrane Central Library, Scientific Electronic Library Online, and Latin American and Caribbean Literature in Health Sciences via Virtual Health Library. The effects of the combined oral contraceptive on plasma renin activity values, plasma renin values, angiotensinogen values— also known as plasma renin substrate— angiotensin, and/or aldosterone values.
Study selection A total of 877 studies were selected and, of these, 10 articles met the eligibility criteria and were included in this review.
Data collection Data were combined through qualitative synthesis and included in a spreadsheet previously prepared by the authors.
Data synthesis The collected samples ranged from 18 to 137 participants, totaling 501 women aged between 18 and 49 years throughout all studies. The studies showed increased activity of plasma renin, plasma renin substrate, angiotensin II, and aldosterone in this population.
Conclusion The findings of this study suggest that the COC promotes greater activation of the RAAS. Supporting the idea that its use is related to an increased risk of cardiovascular events, including systemic arterial hypertension.