bluuebunny/crossref_metadata_2025_split huggingface dataset:
A New Quantitative Triage System for Hospitalized Neonates to Assist with Decisions of Hospital Evacuation Priorities
Authors: Imai Kazunori , Suzuki Tomoko , Fukaya Satoko , Karasawa Yuko , Bando Yoko , Sawaki Daisuke , Araki Yuko , Saitoh Shinji , Iwata Osuke 
Published: April 2022

AbstractIntroduction:Hospitalized neonates are vulnerable to natural and man-made disasters because of their persistent requirement for medical resources and may need to be evacuated to safe locations when electricity and medical gas supply become unreliable. In Japan, a triage system for hospitalized neonates, or the Simple Triage and Rapid Treatment for Neonates, Revised (START-Neo-R), has been used to determine whether neonates are in suitable conditions for transportation. However, this scale is not useful to determine the evacuation order of neonates because a considerable number of evacuees are classified into the same categories.Study Objective:To solve this problem, a novel triage system, Neonatal Extrication Triage (NEXT) was developed. This study tested the validity and reproducibility of both triages and compared them with a standardized prognostic scoring system for hospitalized neonates, the Neonatal Therapeutic Intervention Scoring System (NTISS).Methods:In this retrospective observational study, physicians and nurses independently assessed each neonate hospitalized at a tertiary neonatal intensive care unit (NICU) twice weekly using NEXT and START-Neo-R. The NEXT system comprises six questionnaires regarding medical resources required during transition and transportation, providing composite scores on a 12-point scale. The START-Neo-R classified neonates into five levels based on the severity of disease and dependence on medical care. Inter-rater reliability of both systems was assessed using Cohen’s kappa coefficient, whereas the criterion validity with NTISS was assessed using Spearman’s correlation coefficient.Results:Overall, 162 neonates were assessed for 49 days, resulting in triage data for 1,079 accumulated patients. Both NEXT scores and START-Neo-R ranks were well-dispersed across different levels without excessive accumulation in specific categories. Inter-rater reliability of NEXT (kappa coefficient, 0.973; 95% confidence interval, 0.969-0.976) and START-Neo-R (kappa coefficient, 0.952; 95% confidence interval, 0.946-0.957) between physicians and nurses was sufficiently high. The correlation coefficient of NEXT and START-Neo-R scores with NTISS scores were 0.889 (P <.001) and 0.850 (P <.001), respectively.Conclusions:Both START-Neo-R and NEXT had good reproducibility and correlation with the severity of neonates indicated by NTISS. With its well-dispersed scores across different levels, the NEXT system might be a powerful tool to determine the priority of evacuation objectively.
Focus on rural adolescent cannabis use and abuse: ignored epidemiologic trends, unique risks, long-term concerns, and hope
Authors: Gupta Mayank , Petti Theodore 
Published: April 2022

AbstractCannabis-related issues for adolescents and young adults are emerging from the shadow of rural opioid addiction and deaths. The rural pediatric population has multiple risk factors putting them at increased risk for adverse consequences with the expansion of cannabis legalization across the United States. Research in this area is rich but scattered across professional disciplines. Differences in demographics and cultures between rural and urban youth are gaining attention. Epidemiological factors relevant to rurality as a risk for cannabis and other substance use are considered for formulating clinical care, public policymakers, and future research. Race, culture, community stability, basic demographics of age, gender, educational status, and demands for more and better, accessible services for rural, nonmetropolitan areas comprise factors for consideration and are detailed. Research findings provide direction for policymakers and clinicians for prevention and intervention efforts to improve care for rural populations, validating and expanding upon insights gained to date.
Episodic and prospective memory difficulties in 13-year-old children born very preterm
Authors: Stedall Paulina M. , Spencer-Smith Megan M. , Lah Suncica , Doyle Lex W. , Spittle Alicia J. , Burnett Alice C. , Anderson Peter J. 
Published: April 2022

AbstractObjectives:Children born very preterm (VP) are susceptible to a range of cognitive impairments, yet the effects of VP birth on long-term, episodic, and prospective memory remains unclear. This study examined episodic and prospective memory functioning in children born VP compared with their term-born counterparts at 13 years.Method:VP (n= 81: born <30 weeks’ gestation) and term (n= 26) groups were aged between 12 and 14 years. Children completed: (i) standardized verbal and visuospatial episodic memory tests; and (ii) an experimental time- and event-based prospective memory test that included short-term (within assessment session) and long-term (up to 1-week post-session) tasks. Parents completed a questionnaire assessing memory functions in everyday life.Results:The VP group performed worse on all measures of verbal and visuospatial episodic memory than the term group. While there were no group differences in event-based or long-term prospective memory, the VP group performed worse on time-based and short-term prospective memory tasks than term-born counterparts. Parents of children born VP reported more everyday memory difficulties than parents of children born at term, with parent-ratings indicating significantly elevated rates of everyday memory challenges in children born VP.Conclusions:Children born VP warrant long-term surveillance, as challenges associated with VP birth include memory difficulties at 13 years. This study highlights the need for greater research and clinical attention into childhood functional memory outcomes.
Uninspired by Old White Guys: The Mobilizing Factor of Younger, More Diverse Candidates for Gen Z Women
Authors: Deckman Melissa , McDonald Jared 
Published: April 2022

AbstractAmerican political activism has surged recently among young citizens, particularly among women and people of color. At the same time, record numbers of women and minority candidates have been running for office. Does seeing more diverse candidates in terms of age, gender, and race propel more interest in political engagement among Generation Z, particularly women? Using a survey experiment embedded in a nationally representative survey of Generation Z citizens, we present respondents with Democratic politicians who vary based on these three criteria. Women who identify strongly with their gender express greater political engagement when presented with any candidate who does not fit the stereotypical image of a politician (older, white, male). They are spurred not only by role models who represent them descriptively, but by all politicians belonging to historically marginalized groups. These effects, which are not specific to just Democratic women, provide insights that can inform engagement efforts targeting younger Americans.
Cheating or learning? An investigation into Year 8 students' perceptions of the Cambridge Latin Course Explorer Tool and its role in both classroom teaching and online learning
Authors: Titcombe David 
Published: April 2022

AbstractThis article investigates the different uses of the Cambridge Latin Course Explorer Tool in the classroom, and students' perceptions of this, through a case study of a Year 8 class in an all-girls' comprehensive school. Student perceptions of this tool were a particular focus of the research, exploring its enhancement of students' enjoyment of the subject, its impact on vocabulary retention, and what they considered to be a reduced difficulty of translation. However, it also brought to light students' misgivings about the tool, including a sense of guilt in some pupils, who were of the opinion that their use of the Explorer Tool could be considered as ‘cheating'. Others, meanwhile, felt that it detracted from the ‘process' of translating to the point that they believed it actively hindered their learning.
Gender and the State Politics of Policy Implementation in Education: The Interaction of Bureaucratic and Legislative Representation in India
Authors: Meier Kenneth J. , Dhillon Anita 
Published: April 2022

AbstractRepresentation frequently links state politics to policy. Current research, however, overlooks the interplay between bureaucratic and legislative representation and how local representation may be influenced by state policy environments. There is also a need to test current theories of state politics and policy, driven by the study of US federalism, in different national contexts to indicate how general such theories might be and to provide new insights into the study of US politics and policy. This article studies how gender representation and local policy implementation interacts with state environment factors to affect representation outcomes in K–12 education across 28 states in India. The research points to the generalizability of current theories of representation and state politics across national federal contexts, the conditional nature of the influence of bureaucratic representation on state policy implementation, and the need to better understand the interdependence of representation across political institutions.
Increasing Frequency of Anomalous Precipitation Events in Japan Detected by a Deep Learning Autoencoder
Authors: Murakami H. , Delworth T. L. , Cooke W. F. , Kapnick S. B. , Hsu P.‐C. 
Published: April 2022

AbstractThe frequency of large‐scale anomalous precipitation events associated with heavy precipitation has been increasing in Japan. However, it is unclear if the increase is due to anthropogenic warming or internal variability. Also, it is challenging to develop an objective methodology to identify anomalous events because of the large variety of anomalous precipitation cases. In this study, we applied a deep learning technique to objectively detect anomalous precipitation events in Japan for both observations and simulations using high‐resolution climate models. The results show that the observed increases in anomalous heavy precipitation events in Western Japan during 1977–2015 were not made only by internal variability but the increases in anthropogenic forcing played an important role. Such events will continue to increase in frequency this century. The increases are attributable to the increasing frequency of tropical cyclones and enhanced frontal rainbands near Japan. These results highlight the mitigation challenge posed by the increasing occurrence of unprecedented precipitation events in the future.
Measurement of SST and SSS Using Frequencies in the Range 0.3–2.0 GHz
Authors: Le Vine David M. , Dinnat Emmanuel P. 
Published: April 2022

AbstractWide bandwidth radiometer systems that make measurements at multiple frequencies in the range from 300 MHz to 2 GHz have been proposed to address parameters important for understanding issues in the cryosphere associated with climate change such as ice sheet thickness and temperature. It is also possible with such a system to retrieve sea surface salinity (SSS), which is important for understanding the impact of climate change on ocean circulation at high latitude. In contemporary sensors for retrieving SSS, such as on Soil Moisture and Ocean Salinity (SMOS) and Soil Moisture Active Passive (SMAP), sea surface temperature (SST), another parameter important for understanding ocean circulation and necessary in the retrieval of salinity, is treated as an ancillary parameter obtained from an independent source. However, both SSS and SST have peaks in sensitivity below 1 GHz; and it has been shown that measurements at multiple frequencies in this portion of the spectrum can take advantage of this peak in sensitivity to improve the accuracy of the retrieval of SSS. In this manuscript, it will be shown that there is also the potential to retrieve SST and, in cold water, the possibility for improved accuracy over existing retrievals.
Hydrological Perspectives on Integrated, Coordinated, Open, Networked (ICON) Science
Authors: Acharya Bharat Sharma , Ahmmed Bulbul , Chen Yunxiang , Davison Jason H. , Haygood Lauren , Hensley Robert T. , Kumar Rakesh , Lerback Jory , Liu Haojie , Mehan Sushant , Mehana Mohamed , Patil Sopan D. , Persaud Bhaleka D. , Sullivan Pamela L. , URycki Dawn 
Published: April 2022

AbstractHydrologic sciences depend on data monitoring, analyses, and simulations of hydrologic processes to ensure safe, sufficient, and equal water distribution. These hydrologic data come from but are not limited to primary (lab, plot, and field experiments) and secondary sources (remote sensing, UAVs, hydrologic models) that typically follow FAIR Principles (Findable, Accessible, Interoperable, and Reusable: (go-fair.org)). Easy availability of FAIR data has become possible because the hydrology‐oriented organizations have pushed the community to increase coordination of the protocols for generating data and sharing model platforms. In addition, networking at all levels has emerged with an invigorated effort to activate community science efforts that complement conventional data collection methods. However, it has become difficult to decipher various complex hydrologic processes with increasing data. Machine learning, a branch of artificial intelligence, provide more accurate and faster alternatives to better understand different hydrological processes. The Integrated, Coordinated, Open, Networked (ICON) framework provides a pathway for water users to include and respect diversity, equity, and inclusivity. In addition, ICONs support the integration of peoples with historically marginalized identities into this professional discipline of water sciences. This article comprises three independent commentaries about the state of ICON principles in hydrology and discusses the opportunities and challenges of adopting them.
Acute kidney injury in infants with congenital diaphragmatic hernia
Authors: Arattu Thodika Fahad M. S. , Dassios Theodore , Deep Akash , Greenough Anne 
Published: April 2022

Abstract
Objectives
To assess the incidence of acute kidney injury (AKI) in infants with congenital diaphragmatic hernia (CDH), including those who had fetoscopic endoluminal tracheal occlusion (FETO), and the effect of AKI on mortality and length of stay.

Study design
Ten-year retrospective review of infants admitted with CDH to a tertiary perinatal centre.

Result
Ninety-four infants with median gestational age of 38+1 weeks were included. Fifty-nine (62.8%) infants had AKI. Compared to infants without AKI, infants with AKI, had a similar incidence of mortality (p = 0.989). In survivors, AKI was not independently associated with a longer adjusted median length of stay [23 versus 15 days (p = 0.194)]. FETO was associated with an increased risk of AKI (p = 0.005), but neither the mortality nor length of stay of FETO infants who had AKI was increased.

Conclusion
AKI was present in the majority of infants with CDH and most common in those who had undergone FETO.
Dissecting the clinical heterogeneity of early-onset Alzheimer’s disease
Authors: Sirkis Daniel W. , Bonham Luke W. , Johnson Taylor P. , La Joie Renaud , Yokoyama Jennifer S. 
Published: April 2022

AbstractEarly-onset Alzheimer’s disease (EOAD) is a rare but particularly devastating form of AD. Though notable for its high degree of clinical heterogeneity, EOAD is defined by the same neuropathological hallmarks underlying the more common, late-onset form of AD. In this review, we describe the various clinical syndromes associated with EOAD, including the typical amnestic phenotype as well as atypical variants affecting visuospatial, language, executive, behavioral, and motor functions. We go on to highlight advances in fluid biomarker research and describe how molecular, structural, and functional neuroimaging can be used not only to improve EOAD diagnostic acumen but also enhance our understanding of fundamental pathobiological changes occurring years (and even decades) before the onset of symptoms. In addition, we discuss genetic variation underlying EOAD, including pathogenic variants responsible for the well-known mendelian forms of EOAD as well as variants that may increase risk for the much more common forms of EOAD that are either considered to be sporadic or lack a clear autosomal-dominant inheritance pattern. Intriguingly, specific pathogenic variants inPRNPandMAPT—genes which are more commonly associated with other neurodegenerative diseases—may provide unexpectedly important insights into the formation of AD tau pathology. Genetic analysis of the atypical clinical syndromes associated with EOAD will continue to be challenging given their rarity, but integration of fluid biomarker data, multimodal imaging, and various ‘omics techniques and their application to the study of large, multicenter cohorts will enable future discoveries of fundamental mechanisms underlying the development of EOAD and its varied clinical presentations.
Tumor growth of neurofibromin-deficient cells is driven by decreased respiration and hampered by NAD+ and SIRT3
Authors: Masgras Ionica , Cannino Giuseppe , Ciscato Francesco , Sanchez-Martin Carlos , Darvishi Fereshteh Babaei , Scantamburlo Francesca , Pizzi Marco , Menga Alessio , Fregona Dolores , Castegna Alessandra , Rasola Andrea 
Published: April 2022

AbstractNeurofibromin loss drives neoplastic growth and a rewiring of mitochondrial metabolism. Here we report that neurofibromin ablation dampens expression and activity of NADH dehydrogenase, the respiratory chain complex I, in an ERK-dependent fashion, decreasing both respiration and intracellular NAD+. Expression of the alternative NADH dehydrogenase NDI1 raises NAD+/NADH ratio, enhances the activity of the NAD+-dependent deacetylase SIRT3 and interferes with tumorigenicity in neurofibromin-deficient cells. The antineoplastic effect of NDI1 is mimicked by administration of NAD+ precursors or by rising expression of the NAD+ deacetylase SIRT3 and is synergistic with ablation of the mitochondrial chaperone TRAP1, which augments succinate dehydrogenase activity further contributing to block pro-neoplastic metabolic changes. These findings shed light on bioenergetic adaptations of tumors lacking neurofibromin, linking complex I inhibition to mitochondrial NAD+/NADH unbalance and SIRT3 inhibition, as well as to down-regulation of succinate dehydrogenase. This metabolic rewiring could unveil attractive therapeutic targets for neoplasms related to neurofibromin loss.
MEK and MCL-1 sequential inhibition synergize to enhance rhabdomyosarcoma treatment
Authors: Alcon Clara , Martín Fernando , Prada Estela , Mora Jaume , Soriano Aroa , Guillén Gabriela , Gallego Soledad , Roma Josep , Samitier Josep , Villanueva Alberto , Montero Joan 
Published: April 2022

AbstractTargeted agents have emerged as promising molecules for cancer treatment, but most of them fail to achieve complete tumor regression or attain durable remissions due to tumor adaptations. We used dynamic BH3 profiling to identify targeted agents effectiveness and anti-apoptotic adaptations upon targeted treatment in rhabdomyosarcoma. We focused on studying the use of BH3 mimetics to specifically inhibit pro-survival BCL-2 family proteins, overwhelm resistance to therapy and prevent relapse. We observed that the MEK1/2 inhibitor trametinib rapidly depleted the pro-apoptotic protein NOXA, thus increasing MCL-1 availability. Indeed, we found that the MCL-1 inhibitor S63845 synergistically enhanced trametinib cytotoxicity in rhabdomyosarcoma cells in vitro and in vivo. In conclusion, our findings indicate that the combination of a BH3 mimetic targeting MCL-1 with trametinib improves efficiency on rhabdomyosarcoma by blocking tumor adaptation to treatment.
MOXD1 knockdown suppresses the proliferation and tumor growth of glioblastoma cells via ER stress-inducing apoptosis
Authors: Shi Pengfei , Xu Jie , Xia Fanwei , Wang Yinggang , Ren Jie , Liang Ping , Cui Hongjuan 
Published: April 2022

AbstractOxygenase-catalyzed reduction and activation of oxygen molecules and the incorporation of oxygen atoms into organic molecules are undoubtedly necessary in the process of tumor development, and it is also one of the research hotspots in recent years. MOXD1 belongs to the copper-dependent monooxygenase family. The expression of MOXD1 is one of the characteristics of early tumor development. However, it is not understandable that the biological function and molecular mechanism of MOXD1 in Glioblastoma (GBM). In this study, high MOXD1 expression is strongly associated with poor survival of the patient with GBM. Moreover. MOXD1 knockdown can inhibit cell viability, proliferation, migration, invasion, and tumorigenesis of GBM cells. This is also proven for the first time that MOXD1 can bind to β3GnT2 and affect the glycosylation modification of some proteins. In addition, knockdown of MOXD1 induces endoplasmic reticulum (ER) stress and triggers the ER–mitochondrial apoptosis pathway. Taken together, these results reveal that MOXD1 is involved in the occurrence and development of GBM, and also provide a new strategy for targeted therapy.
Long-term outcome of renal nerve denervation (RDN) for resistant hypertension
Authors: Panchavinnin Pariya , Wanthong Sirisawat , Roubsanthisuk Weranuj , Tresukosol Damras , Buranakitjaroen Peera , Chotruangnapa Chavalit , Watanapa Wattana , Pongakasira Rungtiwa , Wongpraparut Nattawut 
Published: April 2022

AbstractWe aimed to determine the long-term outcome of renal denervation (RDN). All patients with resistant hypertension who underwent RDN between 2012 and 2018 at Siriraj Hospital were included in the study. Patients were followed up at 3, 6, and 12 months and then annually up to 9 years. Effectiveness of the RDN outcome was defined by either (1) a reduction in office systolic BP ≥ 10 mmHg, (2) a reduction in the number of antihypertensive drugs taken, or (3) both outcomes being achieved. In total, 18 RDN procedures were performed during the study period. The mean and longest follow-up periods were 52 months and 104 months, respectively. Heterogeneous BP responses after RDN for resistant hypertension were observed. Effectiveness of the RDN outcome was achieved in 88% of the patients at 1 year and in >80% of the patients during the entire follow-up at each time point up to 9 years.
Histological and chemical diagnosis of a combat lesion in Triceratops
Authors: D’Anastasio Ruggero , Cilli Jacopo , Bacchia Flavio , Fanti Federico , Gobbo Giacomo , Capasso Luigi 
Published: April 2022

AbstractIn the collective imagination derived from scientific and popular literature, Triceratops often faced each other in combat. Thus, from the second half of the twentieth century, these ceratopsids were described as pugnacious animals. This arises primarily from the interpretation of extracranial fenestrae in ceratopsids being the result of combat trauma. However, the diagnosis of the traumatic nature of these anatomical variants of their neck frill requires evidence of bone healing and remodelling by microscopy analysis. Here, we present the case of the Triceratops horridus known as Big John, which is one of the largest specimens discovered in the Hell Creek Formation (Upper Cretaceous; South Dakota, USA). Its right squamosal bone shows an extrafenestra with irregular margins and signs of inflammation. Microscopy analysis revealed newly formed and healing bone, with histological signs typical of the bone remodelling phase. Chemical analysis revealed sulphur that was derived from glycosaminoglycan’s and sulphated glycoproteins of the preosseous osteoid substance present in the healing phases of a bone trauma. Histological and microanalytical analyses confirm that the squamosal fenestra of Big John is the result of a traumatic event, which might indeed have occurred during combat with another Triceratops.