bluuebunny/crossref_metadata_2025_split huggingface dataset:
Genetic polymorphisms of purinergic P2Y2 receptor were associated with the susceptibility to essential hypertension in Chinese postmenopausal women
Authors: Li Ao , Xiong Chaopeng , Gong Chengxin , Gou Mengyang , Wang Yaqun , Yang Yuping , Xu Hong 
Published: August 2022

Abstract
Hypertension has become a prominent public health concern. Essential hypertension (EH) is a polygenic disorder caused by multiple susceptibility genes. It has been previously shown that the purinergic P2Y2 receptor (P2Y2R) regulates blood pressure; however, whether P2Y2R genetic polymorphisms correlate with EH has not been investigated in Chinese. Our study included 500 EH cases and 504 controls who are Chinese postmenopausal women. We used allele-specific polymerase chain reaction (ASPCR) to genotype five single-nucleotide polymorphism (SNPs) in P2Y2R gene, i.e., rs4944831, rs12366239, rs1783596, rs4382936 and rs10898909. We assessed the association of P2Y2R genetic polymorphisms with EH susceptibility. The results demonstrated that P2Y2R rs4382936A was correlated with a high risk of EH; particularly, the participants with the rs4382936A allele and CA/AA/(CA + AA) genotypes were at higher risks to EH compared to the subjects with the rs4382936C allele and CC genotype. Moreover, four P2Y2R haplotypes combined by rs1783596-rs4382936-rs10898909, i.e., CAA, CAG, TAA and TAG, were susceptible haplotypes for EH, whereas haplotype CCG was a protective haplotype for EH. These results may provide new evidence for applying P2Y2R genetic polymorphisms as useful markers in clinic screening or monitoring potential EH cases in a population of Chinese postmenopausal women.
Hydrochemical characteristics and a health risk assessment groundwater area of Warri and its adjoining environs, in Delta State Nigeria
Authors: Eyankware M. O. , Akakuru O. C. , Umayah S. O. , Ukor K. P. 
Published: August 2022

Abstract
In Warri, Delta State, Nigeria, 17 groundwater samples were collected and examined using the American Public Health Association (APHA) method. to evaluate the hydrochemical characteristics and health risks connected with using them as drinking water. For the assessment of the impact of heavy metal contamination in groundwater resources within the region, statistical index analysis using Principal Component Analysis (PCA) and Pearson correlation, heavy metal index such as Contamination Index (CI), Contamination Factor (Cf), Pollution Load Index (PLI), Metal Pollution Index (MPI), Quantification of Contamination (QoC), Potential Ecological Risk Index (ERI), and Pollution Index of Groundwater (PIG) were successfully applied. Additional findings from Pearson correlation and Principal Component Analysis (PCA) suggested that there is an interaction within the groundwater aquifer system and that there are weak to moderate relationships between parameters. PCA also suggests that loadings within the groundwater system may have resulted from anthropogenic activities in the area that are affecting the water chemistry. Results from hydrogeochemical facies showed that in the cation area, Na+K > Mg > Ca > Cl > SO4 > HCO3 with a tendency of 35.3 percent SO4 > 5.9 percent HCO3 > 41.2 percent Cl > 17.6 percent no dominant ionic specie. Findings from heavy metals indexes like Cf and PLI suggested that there is no connection between them and the groundwater that is readily available. Additional MPI results showed that the research area's groundwater is regarded as clean, whereas QoC and ERI findings showed that geological processes promote the transport of heavy metals, the possible ecological danger associated with groundwater. The HI for all indicators was higher in children than in adults, according to health risk data. This increasing HI in the studied area may be primarily due to anthropogenic sources. According to the findings, ongoing groundwater assessment is necessary to warn against a decline in groundwater quality in the research region.
Porous and three-dimensional carbon aerogels from nanocellulose/pristine graphene for high-performance supercapacitor electrodes
Authors: Wang Yaqi , Yang Junwei , Song Yiheng , Yang Quanling , Xiong Chuanxi , Shi Zhuqun 
Published: August 2022

Abstract
Bio-based materials with good electrical properties produced by environmentally friendly methods have been increasingly applied in battery and supercapacitor technologies. In this work, we used 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO)-oxidized cellulose nanofibers (TOCN) and pristine graphene (PG) as precursors to fabricate three-dimensional (3D) carbon aerogels with outstanding conductivity via freeze-drying followed by carbonization. The specific capacitance of the carbonized TOCN/PG (CTG) aerogels reached 134.09 F/g at a current density of 0.5 A/g. Meanwhile, a better cycling stability was achieved and the capacitance retained 98.89% after 5000 cycles. As the temperature increased to 1100°C, the electrochemical performance of the CTOCN-1100 electrode was improved significantly with a specific capacitance of 361.74 F/g at a current density of 0.5 A/g, and the capacitance still retained as high as 99.3% after 5000 cycles. Therefore, these bio-based cellulose nanofibrils are promising in the field of supercapacitors.
Flame-Retardancy Finishing of Cotton Fabric by Surface-Initiated Photochemically Induced Atom Transfer Radical Polymerization
Authors: Zain Gamal , Jordanov Igor , Bischof Sandra , Magovac Eva , Šišková Alena Opálková , Vykydalová Anna , Kleinová Angela , Mičušík Matej , Mosnáčkova Katarína , Doháňošová Jana , Mosnáček Jaroslav 
Published: August 2022

Abstract
Phosphorus-containing polymers are very promising because of the versatility of their applications. Polyphosphates and polyphosphonates are well-known for their excellent fire-retardant properties. In this work, a cotton fabric was grafted by oxygen-tolerant photochemically induced atom transfer radical polymerization (photoATRP) of dimethyl(methacryloyloxymethyl) phosphonate (MAPC1) in order to prepare flame resistant fabric. The photoATRP of MAPC1 was first optimized in solution and subsequently used for surface-initiated polymerization from of cotton fabric pre-functionalized by ATRP initiator in order to achieve PMAPC1 brushes onto the surface. The modified cotton fabrics were characterized by attenuated total reflection–Fourier transforms infrared spectroscopy and X-ray photoelectron spectroscopy to prove successful grafting. Minimal effect of grafting on mechanical properties of the cotton fabric was confirmed by tensile tests. The thermal properties and flammability of the modified fabric were tested by thermogravimetric analysis, horizontal and vertical flame tests. Limiting oxygen index and microscale cone calorimeter were performed as well. The results show that modified fabric has a high flame resistance making it a good candidate for flame-retardant application. Washing tests confirmed that the grafted layer on the fabric has good durability from the point of view of retention of high flame resistance.
Olea Europaea L. leaf extract attenuates histological alterations and oxidative stress in the rat heart induced by combined exposure to noise and toluene.
Authors: ATTIA Takoua BEN , ALI Ridha BEN , NAHDI Afef , GALAI Said , GHALI Ridha , RAMMEH Soumaya , MAY Michèle véronique EL , MHAMDI Abada 
Published: August 2022

Abstract
Toluene is a solvent widely produced and used by the industrial sector. Noise is a nuisance present in many professional sectors. We aimed to investigate in the present study the impact of exposure to toluene (300 ppm) and/or noise 85 dB(A) on rat heart and to assess the preventive effect of olive leaf extract OLE (40 mg/Kg/day) administrated for six weeks (5 days/week). Forty-eight male Wistar rats were divided into 8 groups (n = 6/group): C: control group, C+OLE: control group received OLE, N: group exposed to noise, N+OLE: group exposed to noise and received OLE, T: group exposed to toluene, T+OLE: group exposed to toluene and received OLE, NT: group co-exposed to noise and toluene, NT+OLE: group co-exposed to noise and toluene received. At the end of the experimental period, heart and blood samples were collected. Plasma cholesterol (CHOL), triglycerides (TG), lactate dehydrogenase (LDH) and creatine kinase (CK) levels were determined. Histopathological investigation was determined by HE staining. Superoxide dismutase (SOD), catalase (CAT) activities and malondialdehyde (MDA) level in heart tissue were also measured. Our results showed that Simultaneous exposure to noise and toluene altered CHOL, TG, LDH and CK levels. In parallel, an increase in lipid peroxidation levels and Superoxide dismutase activity with a decrease in catalase activity in the heart were shown. A significant alteration in the myocardium was also recorded. OLE treatment modulated theses oxidative and histological changes. In conclusion, OLE was found to correct the deleterious effects induced by combined exposure to noise and toluene.
Risk factors of mediastinal lymph node metastasis and lung metastasis in papillary thyroid carcinoma patients: Who benefits from preoperative computed tomography?
Authors: Omi Yoko , Yanagida Juro , Yoshida Yusaku , Horiuchi Kiyomi , Okamoto Takahiro 
Published: August 2022

Abstract

Purpose: In papillary thyroid carcinoma (PTC) patients with mediastinal lesion and lung metastases, adding preoperative computed tomography (CT) to ultrasound aids in determining surgical procedures. We identified the risk factors (RFs) of mediastinal lymph node metastasis (MLNM) and lung metastasis in PTC patients who benefit from CT. Methods: The frequency of MLNM and lung metastasis was compared using data from 478 patients. Relative risk (RR) was calculated according to RFs. Results: MLNM or lung metastasis was detected in 1.2% and 3.3%. cT3-4, cN1, central LN metastasis, and lateral LN metastasis were RFs of MLNM in all patients (p<0.05, p<0.05, p<0.05, p<0.01) and those ≥55 years old (older patients) (p<0.01, p<0.05, p<0.05, p<0.05). cT3-4, cN1, gross extrathyroidal extension, central LN metastasis, and lateral LN metastasis were RFs of lung metastasis in all patients (p<0.01, p<0.05, p<0.01, p<0.01, p<0.01). cN1 and gross extrathyroidal extension, central LN metastasis, and lateral LN metastasis in older patients (p<0.01, p<0.01, p<0.05, p<0.01) and lateral LN metastasis in those <55 years old (younger patients) (p<0.05) were RFs of lung metastasis. The RRs of patients with cT3-4 and cN1 were 16.8 (95% confidence interval [CI]: 2.9-97.5) in all patients and 28.7 (95% CI: 3.1-261.4) in older patients for MLNM and 4.4 (95% CI: 1.5-13.3) in all patients, 2.55 (95% CI: 0.3-20.6) in younger patients, and 5.6 (95% CI: 1.5-21.5) in older patients for lung metastasis. Conclusion: PTC patients with cT3-4 and cN1 have a risk of MLNM and lung metastasis. RFs differed between older and younger patients.
Changes in biological soil health properties in response to increased crop diversity in a dryland wheat-based cropping system
Authors: Eberly Jed O. , Hammontree Jenni W. , Fordyce Simon I , Jones Clain A. , Carr Patrick M. 
Published: August 2022

Abstract

Diversifying wheat (Triticum aestivum L.)-based cropping systems can be an effective management tool to break weed and disease cycles. While extensive research has focused on the agronomic benefits of increased crop diversity in semi-arid environments, less is known about the impacts of increased crop diversity on microbial community structure and processes such as nitrogen (N) cycling. This work compared a continuous wheat crop sequence to a diverse sequence that included pea (Pisum sativum L.), proso millet (Panicum miliaceum L.), safflower (Carthamus tinctorius, L.), and spring wheat. Soil inorganic N (NO3-N and NH4-N), soil respiration, microbial biomass, enzyme activity, and microbial community alpha diversity, a measure of the number of taxa within a treatment, were determined. Soil respiration was higher (p < 0.005) in the diverse sequence while activity of N-acyl-β-D-glucosaminidase, an enzymatic indicator of C and N mineralization, was lower (p < 0.05) with a mean rate of 26.3 mg ρ-nitrophenol kg− 1 soil h− 1 and 16.3 mg ρ-nitrophenol kg− 1 soil h− 1 for the continuous wheat and diverse sequences, respectively. Soil respiration was weakly correlated to soil water content (R2 = 0.21) and temperature (R2 = 0.29) in the diverse rotation, while only weakly correlated to soil water content (R2 = 0.05) in the continuous wheat system (p < 0.001). The mean net N mineralized under a wheat crop during the growing season was 33.2 ± 2.5 kg ha− 1 and was not different between treatments (p > 0.05). Microbial community analysis showed no difference in bacterial alpha diversity, while fungal community diversity was 52% lower in the diverse rotation. The results of this work suggest that specific crops in a rotation may impact microbial processes related to N mineralization and that the soil fungal community may be more sensitive to changes in crop sequence than the soil bacterial community.
A prediction model for cement specific surface area based on Dual Temporal Extraction Network
Authors: Sun Chao , Guo Haoran , Liu Pengfei , Zhang Yuan , Zhao Haichao , Hao Xiaochen 
Published: August 2022

Abstract
The accuracy of the predicted value of specific surface area plays a significant guiding function in the production and scheduling of cement, as it is a major index impacting the quality of cement. However, due to data characteristics in the cement grinding process, such as time delay, strong coupling and nonlinearity, and the traditional prediction model being a static small sample feature acquisition method based on time correlation, problems such as poor data feature representation and low accuracy exist. In order to achieve an accurate prediction of cement specific surface area, we propose a deep learning prediction model based on Dual Temporal Extraction Network (DTENet). This network is divided into two parts: encoder and decoder. The network uses a dual temporal feature extraction mechanism in the encoder part. Different from the LSTM network which only focuses on the correlation information of a single time step, we realize the mechanism of temporal feature extraction in the short term and long term respectively by constructing a two-stage sliding window to send the data into different temporal feature extraction networks. This network can greatly improve the prediction accuracy for cement specific surface area data with large time lag, redundancy and variable working conditions. In the decoder part, we use the channel attention approach to enhance the spatial information extraction capability of the model. The result of the experiments shows that our model has superior accuracy in cement specific surface area prediction when compared to LSTM, XGBoost and ARIMA models.
Abdominal obesity, rather than overall obesity, is a causal risk factor for pancreatic cancer
Authors: Prokopenko Inga , Maina Jared , Pascat Vincent , Zudina Liudmila , Ulrich Anna , Pupko Igor , Balkhiyarova Zhanna , Kaakinen Marika , Froguel Philippe 
Published: August 2022

Abstract
Obesity and type 2 diabetes (T2D) are associated with increased risk of pancreatic cancer. Here we assessed the relationship between pancreatic cancer and two distinct measures of obesity, namely total adiposity, using BMI, versus abdominal, using BMI adjusted waist-to-hip ratio (WHRadjBMI) using polygenic scores (PGS) and Mendelian randomization (MR). We constructed z-score weighted PGS for BMI and WHRadjBMI using publicly available data and tested for their association with pancreatic cancer defined in UK biobank (UKBB). Using publicly available summary statistics we then performed bi-directional MR analyses between the two obesity traits and pancreatic cancer. PGSBMI was significantly (multiple testing-corrected) associated with pancreatic cancer (OR[95%CI] = 1.077[1.023–1.13], P = 0.0052). The significance of association declined after T2D adjustment (OR[95%CI] = 1.069[1.015–1.079], P = 0.012). MR analyses showed a nominally significant causal effect of WHRadjBMI on pancreatic cancer (OR[95%CI] = 1.00095[1.00011–1.0018], P = 0.027). Overall, we show that abdominal adiposity measured using WHRadjBMI, is a more important causal risk factor for pancreatic cancer compared to total adiposity, with T2D being a potential driver of this relationship.
Dexmedetomidine attenuates the enhancement effect of propofol on conditioned fear memory in rats
Authors: Yu Youjia , Xu Qingrong , Zha Jun , Wang Xinyi , Heng Lei , Yao Rui 
Published: August 2022

Abstract
Objective
Posttraumatic stress disorder (PTSD) is a frequent and disabling consequence of traumatic events. A previous study found that dexmedetomidine can alleviate anxiety like behavior and cognitive impairment in PTSD model rats. The aim of this study was to investigate the the effects of dexmedetomidine on the dosage and time window of conditioned fear memory enhanced by propofol in rats.
Methods
After conditioned fear training and propofol injection, the proportion of freezing time in rats with different doses and timing by dexmedetomidine were evaluated. We also examined The activation of excitatory and inhibitory neurons in the basolateral amygdala (BLA) by dual-labeling immunofluorescence.
Results
Propofol heightened the freezing time in the context fear conditioning test. After propofol injection, the fluorescence intensity of c-Fos in dual-localization with CaMKⅡ increased and the fluorescence intensity of c-Fos in dual-localization with GAD67 declined in the basolateral amygdala (BLA). The use of medium or high concentration of dexmedetomidine reduced the freezing time of rats injected with propofol, so did the immediate and early use. However, high concentration of dexmedetomidine significantly increased respiratory depression. After giving dexmedetomidine to rats rejected with propofol, the fluorescence intensity of c-Fos in dual-localization with CaMKⅡ declined and the fluorescence intensity of c-Fos in dual-localization with GAD67 increased in the BLA.
Conclusion
Dexmedetomidine can attenuate the enhancement effect of propofol on conditioned fear memory in rats, and the best effect is achieved by early administration of moderate dose (20µg/kg) (within 30 min after propofol administration).
The numbers of nontrivial solutions to p-Laplacian impulsive equations with nonhomogeneous Neumann boundary conditions
Authors: Yang Guoping , Liu Jian 
Published: August 2022

Abstract
The sufficient condition of the existence of solutions to some superlinear p-Laplacian impulsive differential equations with nonhomogeneous Neumann boundary conditions is obtained. We get two theorems via variational methods and corresponding critical-points theorems. To reveal the value of obtained theorems, two examples are presented combining with the Newton-iterative method.MSC: 34B15;58E30
Influence of large-scale climate signals on theprecipitation variability over Iran
Authors: Javanshiri Zohreh , Babaeian Iman , Pakdaman Morteza 
Published: August 2022

Abstract
This study investigates relationships between the twenty large-scale climatesignals and the precipitation variability during 1960–2018 in Iran.The twenty large-scale climate indicators include atmosphere-ocean teleconnectionsas well as El Ni˜no and Southern Oscillation (ENSO) signals,Pacific and Atlantic ocean Sea Surface Temperature (SST). WaveletCoherence Analysis (WCA) was applied to detect the impact of climatesignals on Iran’s monthly precipitation. The results revealed that (a) thesignificant wavelet coherence and the phase difference between monthlyprecipitation and climate signals were highly variable in time and periodicity,(b) at inter-annual scale, Iran’s precipitation had been linked moreto Extreme Eastern Tropical Pacific SST(0◦-10◦S, 90◦-80◦W) (Ni˜no1.2), Oceanic Ni˜no Index (ONI), and Western Hemisphere Warm Pool(WHWP), respectively, (c) decadal and inter-decadal precipitation variabilityare mainly associated with variability in Atlantic Meridional Mode(AMM), Western Pacific Index (WP) and Arctic Oscillation (AO), and(d) in the most recent decade, the coherence between precipitation andlarge-scale climate signals has been declined in decade and inter-decadescales, and an unstable coherence has been emerged in annual scale.
Combined Run-Length and Huffman Encoding for Image Compression
Authors: Krainyk Yaroslav 
Published: August 2022

Abstract
The paper introduces combined Run-Length encoding (RLE) and Huffman encoding approach for image compression. The approach can be applied to the peculiar type of images that satisfies specific characteristics in terms of color components data. The devised approach is supposed to implement lossless compression for the preprocessed image data. First, the RLE is applied to the prepared data, then, Huffman coding process is performed. The results received during the test session of the implemented software showcase that the proposed technique is feasible and provides a decent level of compression. It can be implemented also in the hardware since the complexity of the operations used is relatively low.
Evidence for possible overestimation of systematic reliability of Type Ia Supernovae for measuring extragalactic distances
Authors: Singh Ritesh 
Published: August 2022

Abstract

We investigate systematic reliability of Type Ia Supernovae (SNe Ia) as an extragalactic distance measurement method. First we review the evidence for potential sources of underestimated uncertainty and bias in SNe Ia distance measurements. Then we invite attention to the fact that most estimates of systematic uncertainty in SNe Ia distances do not take into account the uncertainties in the other distance measurement methods on which the SNe Ia distance scale is calibrated. With this backdrop, we analyse 17,371 reported SNe Ia distances for 3,743 galaxies compiled in the NED Redshift Independent Distances database. We find that any two reported SNe Ia distance measurements for a galaxy differ by 2.84 times the reported uncertainty on average. Among all the ordered pairs of multiple reported SNe Ia distances for the same galaxy, over all the galaxies, we find that 37.65\% of the ordered pairs differ by more than twice the reported uncertainty. This points towards possible underestimation of the reported uncertainties in SNe Ia distances. We also find that this percentage of ordered pairs of SNe Ia distances differing by more than twice the reported uncertainty shows a monotonically increasing trend from 1999 to 2018, pointing towards increasing underestimation of uncertainties with the period of publication. Using data from the Sloan Digital Sky Survey II, we find that the uncertainty introduced by the choice of MLCS2k2 versus SALT2 light curve models is 2.41 times the uncertainty reported in an individual measurement on average.
Identifying the difficulties faced by parents of children with colostomy due to hirschsprung's disease: a phenomenological study
Authors: Sahin Sennur Kula , Karakas Gulsah 
Published: August 2022

Abstract
Purpose: This study was carried out to determine the difficulties faced by the parents of children with colostomy due to Hirschsprung's Disease. Methods: This phenomenological study was conducted. The study included the parents of nine different children with colostomys from October 2017 to January 2018 and used the purposeful sampling technique. Data was collected by voice recorder and camera utilizing the in-depth interview method and a “Semi-Structured Interview Form.” Malterud's systematic text condensation method was used to evaluate the data. Results: The study identified three main themes of “first encounter”, “difficulties” and “coping”; and twelve subthemes regarding the difficulties experienced by parents of children with colostomy. However, it was determined that parents accepted this process by using coping methods that include positive attitudes and spiritual beliefs. Conclusions: Starting with the decision to open a colostomy on children, it is recommend for parents to have education by professional counselling on colostomy care, psychological counseling and social groups, family centered care that help expressing their feelings.