bluuebunny/crossref_metadata_2025_split huggingface dataset:
ДИНАМІКА АКТИВНОСТІ ПРОЦЕСІВ ЛІПІДНОЇ ПЕРОКСИДАЦІЇ В ПІЗНІЙ ПЕРІОД КРАНІОСКЕЛЕТНОЇ ТРАВМИ ЗА УМОВ ХРОНІЧНОГО ГЕПАТИТУ ТА ЕФЕКТИВНІСТЬ КОРЕКЦІЇ АРМАДІНОМ
Authors: Прохоренко О. О. , Цимбалюк Г. Ю. 
Published: March 2022

Вступ. Травматизм належить до актуальних медичних і соціальних проблем сьогодення. Останнім часом значно збільшилась вірогідність отримання травм на тлі супутніх дифузних захворювань печінки, частота яких постійно зростає. Одним з об’єктів системної відповіді організму на травму є печінка, в якій унаслідок травматичної хвороби суттєво посилюються процеси ліпідної пероксидації.
Мета дослідження – з’ясувати динаміку активності процесів ліпідної пероксидації в печінці в пізній період краніоскелетної травми за умов хронічного гепатиту та оцінити ефективність корекції армадіном.
Методи дослідження. Експерименти виконано на 136 нелінійних білих щурах-самцях масою 200–220 г. У 1-й дослідній групі наносили краніоскелетну травму, в 2-й – аналогічну травму наносили після моделювання хронічного гепатиту (C. P. Siegers та ін., 1982), у 3-й – моделювали хронічний гепатит, наносили травму і з метою корекції щоденно внутрішньочеревно вводили армадін у дозі 20 мг/кг, починаючи з 15-ї доби після травматичного періоду. Тварин виводили з експерименту через 14, 21, 28 і 35 діб після нанесення травми. Контрольними стали групи інтактних тварин та щурів із хронічним гепатитом. У печінці піддослідних тварин визначали вміст реагентів до тіобарбітурової кислоти (ТБК-активних продуктів пероксидного окиснення ліпідів).
Результати й обговорення. Моделювання краніоскелетної травми супроводжувалось активацією в печінці процесів ліпідної пероксидації. Вміст у печінці ТБК-активних продуктів пероксидного окиснення ліпідів протягом усього терміну експерименту був істотно більшим, ніж у контрольних групах. За умов нанесення краніоскелетної травми на тлі супутнього хронічного гепатиту вміст ТБК-активних продуктів пероксидного окиснення ліпідів суттєво перевищував такий у групі травмованих тварин без цього захворювання. Застосування армадіну сприяло зменшенню інтенсивності ліпідної пероксидації в печінці при нанесенні краніоскелетної травми на тлі хронічного гепатиту. Порівняно з тваринами без корекції результат виявився статистично вірогідним через 21 і 35 діб.
Висновки. Моделювання краніоскелетної травми на тлі хронічного гепатиту в період пізніх проявів травматичної хвороби зумовлює тривале посилення активності процесів ліпідної пероксидації в печінці, яке до 35-ї доби експерименту не досягає рівня контролю. Застосування армадіну, порівняно з тваринами без корекції, викликає зниження вмісту в печінці ТБК-активних продуктів пероксидного окиснення ліпідів, починаючи з 21-ї доби експерименту.
ТОКСИКОЛОГІЧНІ ВЛАСТИВОСТІ КАРБОНОВИХ НАНОТРУБОК
Authors: Летняк Н. Я. 
Published: March 2022

Вступ. У статті проаналізовано наявні літературні дані щодо основних властивостей вуглецевих нанотрубок як одного з найважливіших наноматеріалів. Вуглецеві нанотрубки мають унікальні механічні, електро- і теплопровідні властивості, їх широко використовують у наукових дослідженнях, промисловості та медицині. Нанотехнології на сьогодні є найбільш перспективним у розвитку світової науки напрямком. Наноматеріали стали причиною справжнього прориву в багатьох галузях і проникають у всі сфери нашого життя. Одним із пріоритетних видів наноматеріалів є вуглецеві нанотрубки. Це мультифункціо­нальні матеріали, які активно досліджують у зв’язку з їх унікальними фізико-хімічними властивостями. Вони існують у різноманітних формах та можуть бути хімічно модифіковані функціональними групами біомолекул. Нанотрубки є перспективним наноматеріалом для використання в медицині завдяки надзвичайно високому рівню біосумісності їх із кров’ю, кістками, хрящами і м’якими тканинами. Їх можна використовувати для створення штучних серцевих клапанів, діагностики і терапії ракових захворювань, а також для транспортування протеїнів, антигенів, генів, вакцин та лікарських речовин у клітину. Акцентовано увагу на тому, що вуглецеві нанотрубки відкривають нові можливості для біологічного та медичного застосування: візуалізація молекулярних, клітинних і тканинних структур; створення біосенсорів і електродів на їх основі; цільова доставка різноманітних речовин; променева і фототермічна терапія. З повсякденним зростанням темпів використання наноматеріалів усе менше уваги приділяють можливим негативним впливам наночастинок на безпеку навколишнього середовища та на здоров’я людей у цілому. Малий розмір, специфічна структура, велика площа поверхні, хімічний склад насторожують щодо можливого токсичного впливу на організм людини. Залежно від шляху введення в організм та дози вуглецеві нанотрубки є потенційно небезпечними для нього. Зважаючи на це, виникає необхідність у вивченні їх токсикологічних властивостей.
Мета дослідження – проаналізувати сучасні літературні джерела щодо особливостей токсикологічного впливу вуглецевих нанотрубок.
Висновки. Наявна на сьогодні незначна кількість досліджень у цьому напрямку вказує на те, що наноматеріали можуть бути токсичними. Тому перспективи широкого застосування зумовлюють необхідність продовження досліджень особливостей їх впливу на здоров’я людини.
Upregulation of Endothelial DKK1 (Dickkopf 1) Promotes the Development of Pulmonary Hypertension Through the Sp1 (Specificity Protein 1)/SHMT2 (Serine Hydroxymethyltransferase 2) Pathway
Authors: Wang Qianqian , Tian Jingjing , Li Xuan , Liu Xiaolin , Zheng Tengfei , Zhao Yachao , Li Xiao , Zhong Hongyu , Liu Dongdong , Zhang Wencheng , Zhang Meng , Li Mengmeng , Zhang Mei 
Published: March 2022

Background:
Pulmonary hypertension (PH) is a cancer-like proliferative disease, which has no curative treatment options. The dysfunction of pulmonary artery endothelial cells plays a key role in PH. DKK1 (Dickkopf 1) is a secretory glycoprotein that exerts proproliferative effects on tumor cells. In the present study, we aimed to identify the role and underlying mechanism of DKK1 in the development of PH, which still remain unclear.

Methods and Results:

We found endothelial DKK1 expression was upregulated in serum and lung tissues obtained from patients with PH, mice with hypoxia-induced PH, and human pulmonary artery endothelial cells cultured under hypoxic conditions. Endothelium-specific DKK1-knockout (DKK1
ECKO
) mice significantly ameliorated hypoxia+Sugen5416 and hypoxia-induced PH. More importantly, neutralizing anti-DKK1 antibody treatment significantly attenuated established hypoxia+Sugen5416 PH. Results of proteome analysis of control and DKK1-knockdown human pulmonary artery endothelial cells identified a significantly differentially expressed protein, SHMT2 (serine hydroxymethyltransferase 2), a key metabolic enzyme in one-carbon metabolism, as a novel DKK1 target. DKK1 knockdown in human pulmonary artery endothelial cells cultured under hypoxic conditions decreased the cellular NADPH/NADP+ ratio, increased reactive oxygen species levels and the extent of mitochondrial DNA damage, and inhibited mitochondrial membrane hyperpolarization. In the context of this altered redox defense and mitochondrial disorder, DKK1 induced a proproliferative and antiapoptotic phenotype in endothelial cells. Furthermore, we confirmed that DKK1 regulated SHMT2 transcription through the AKT–Sp1 (specificity protein 1) signaling axis.

Conclusions:
Our data provide robust evidence and molecular explanations for the associations between DKK1, redox defense, mitochondrial disorders, and PH and reveal a novel target for PH treatment.
Adolescent Blood Pressure and the Risk for Early Kidney Damage in Young Adulthood
Authors: Tsur Avishai M. , Akavian Inbal , Derazne Estela , Tzur Dorit , Vivante Asaf , Grossman Ehud , Rotem Ran S. , Fishman Boris , Afek Arnon , Coresh Josef , Chodick Gabriel , Twig Gilad 
Published: March 2022

Background:
Recent guidelines classified blood pressure above 130/80 mm Hg as hypertension. However, outcome data were lacking.

Objective:
To determine the association between blood pressure in adolescence and the risk for early kidney damage in young adulthood.

Methods:

In this nationwide cohort study, we included 629 168 adolescents aged 16 to 20 who underwent medical examinations before mandatory military service in Israel. We excluded 30 466 adolescents with kidney pathology, hypertension, or missing blood pressure or anthropometric data at study entry. Blood pressure measurements at study entry were categorized according to the Clinical Practice Guideline for Screening and Management of High Blood Pressure in Children and Adolescents: group A (<120/<80 mm Hg; Reference group), group B (120/<80–129/<80 mm Hg), group C (130/80–139/89 mm Hg), and group D (≥140/90 mm Hg). Early kidney damage in young adulthood was defined as albuminuria of ≥30 mg/g with an estimated glomerular filtration rate of 60 mL/(min·1.73 m
2
) or over.

Results:
Of 598 702 adolescents (54% men), 2004 (0.3%) developed early kidney damage during a mean follow-up of 15.1 (7.2) years. The adjusted hazard ratios for early kidney damage in blood pressure group C were 1.17 (1.03–1.32) and 1.51 (1.22–1.86) among adolescents with lean (body mass index <85th percentile) and high body mass index (body mass index ≥85th percentile), respectively. Corresponding hazard ratios for kidney disease in group D were 1.49 (1.15–1.93) and 1.79 (1.35–2.38) among adolescents with lean and high body mass index, respectively.

Conclusions:
Blood pressure of ≥130/80 mm Hg was associated with early kidney damage in young adulthood, especially in adolescents with overweight and obesity.
Pilot Study on the Intercalibration of a Categorisation System for
FAIRer Digital Objects Related to Sensitive Data in the Life
Sciences
Authors: Ohmann Christian , David Romain , Abadia Mónica Cano , Bietrix Florence , Boiten Jan-Willem , Canham Steve , Chiusano Maria Luisa , Dastrù Walter , Laroquette Arnaud , Longo Dario , Mayrhofer Michaela Theresia , Panagiotopoulou Maria , Richard Audrey , Verde Pablo Emilio 
Published: March 2022

Abstract
Sharing sensitive data is a specific challenge for research infrastructures in the field of life sciences. For that reason a toolbox has been developed, providing resources for researchers who wish to share and use sensitive data, to support the workflows for handling these kinds of digital objects. Common and community approved annotations are required to be compliant with FAIR principles (Findability, Accessibility, Interoperability, Reusability). The toolbox makes use of a tagging (categorisation) system, allowing consistent labelling and categorisation of digital objects, in terms relevant to data sharing tasks and activities. A pilot study was performed within the Horizon 2020 project EOSC-Life, in which 2 experts from 6 life sciences research infrastructures were recruited to independently assign tags to the same set of 10 to 25 resources related to sensitive data management and data sharing (in total 110). Summary statistics of agreement and observer variation per research infrastructure are provided. The pilot study has shown that experts were able to attribute tags but in most cases with a considerable observer variation between experts. In the context of CWFR (Canonical Workflow Frameworks for Research), this indicates the necessity for careful definition, evaluation and validation of parameters and processes related to workflow descriptions. The results from this pilot study were used to tackle this issue by revising the categorisation system and providing an updated version.
Contemporary issues of languaging, participation and ways-of-being
Authors: Bagga-Gupta Sangeeta 
Published: March 2022

Abstract
This paper introduces the theme of Languaging, Diversity and Democracy. Contemporary issues of participation and ways-of-being and positions the 12 individual papers that constitute the 2022 double special issue of Bandung: Journal of the Global South. Its interest lies in contributing to knowledge that is relevant for contemporary human challenges related to issues of mobility, digitalization, and communication in and across different geopolitical regions across the planet and across virtual-physical spaces. Raising concerns regarding universalizing tendencies of special issues (and collected volumes generally), and based on the premise that what kind of knowledge matters is tied up with the issue of whose knowledge and in what named-language this knowledge matters, this paper raises critical queries that focus on the narrators positionality and gaze, the composition of scholarly narratives, the flow of narratives, what vocabularies circulate in frontline scholarship, including the organization of special issues, etc. Drawing attention to the universalizing Euro/America-centrism that shapes what counts as knowledge, the paper draws attention to the taken-for-grantedness of what counts as international languages of publishing which eclipses alternative epistemologies, ways-of-thinking and ways-of-being. It argues that by taking such issues as inspiration in the curation and editing of this double special issue, participatory processes and ways-of-being enabled a contribution to the doing of democracy and diversity in the scholarly enterprise. Such work of democratizing academic publication work calls for unlearning to learn that is closely related to the theme explored in the double special issue. Aligning with analogue-digital languaging in contemporary existence, the paper also traces the journey of how this double special issue has come into being.
Resisting Commodification: Subverting the Power of the Global Tech Companies
Authors: Bäcke Maria 
Published: March 2022

Abstract
In our digitised world, information and communication technologies (ict s) are used everywhere. In schools all over the world the well-known, easy-to-use, and highly affordable Google Education is used, but is this a safe and sustainable solution? A number of services online are free in terms of users not having to pay any money for their usage, but many companies, of which Google is one, instead make their money from the exploitation of what is labelled non-personal user data, Big Data, which is harvested from the users of their free services. This type of data mining or data harvesting can be used for other purposes as well, such as for intelligence reasons, where a foreign power may capitalise on user data from another country, but it may also be to control a country’s own population. Asymmetrical power distribution is inevitable and, drawing on Deleuze and Guattari’s theories of power and subversion, my aim is to increase the awareness of the non-monetary costs involved in the choice of ict s and highlight ways to shift the inherent hierarchic power. A text analysis, based on policy documents and articles focusing on online privacy, data harvesting and user commodification, studies how legislators, journalists, as well as governmental and other organisations negotiate and sometimes subvert the hierarchic power of the global tech companies in order to protect privacy, integrity and democracy as well as the profit margin of companies. The paper highlights the need for legislation and education, an enhanced ict literacy, in the field.
Leader and follower: Towards the Organization for Economic Co-operation and Development’s two interactional categories to describe learning situations?
Authors: Lefebvre Augustin 
Published: March 2022

Abstract
This paper offers a critique of learning viewed solely through the categories of formal Vs. informal education as used by the Organization for Economic Co-operation and Development (oecd). This critique is based on the perspectives of ethnomethodology, conversation analysis and sociocultural theory. It considers that any learning consists of the construction of a common object between participants. I examine two possible organizations of interaction as participants construct their learning objects in situations that are glossed as second language learning. In the first case, the activity is led by the teacher, in the second case, by the learner. The article shows that this difference in the organization of social interaction has consequences on the organization of a proximal zone of development and therefore has consequences for learning opportunities. In conclusion, the article proposes to add to the typologies of learning, the interactional categories of leader and follower in order to specify the roles of the teacher and learner in a large number of learning situations.
Development and Validation of Instrument for Operative Competency Assessment in Selective Neck Dissection
Authors: Dowling Eric , Larson David , Carlson Matthew L. , Price Daniel L. 
Published: March 2022

Background: Instruments to assess surgical skills have been validated for several key indicator procedures in otolaryngology. Selective neck dissection is a core procedure for which trainees must integrate knowledge of complex head and neck anatomy with technical surgical skills. An instrument for assessment of surgical performance in selective neck dissection has not been previously developed. The objective of the current study is to develop and validate an instrument for assessing surgical competency for level II-IV selective neck dissection. Design: A Delphi working group comprised of 23 fellowship trained head and neck surgeons from 17 institutions was assembled. The modified Delphi method encompassed a 3-step process, including 2 anonymous voting rounds to successively refine individual items and establish levels of consensus. Thresholds for achieving strong consensus, at >80% agreement, were determined a priori. The resulting instrument was subsequently validated in a prospective cohort of 17 resident surgeons, spanning postgraduate year 1 to 5 training experience. Participants were asked to perform a level II-IV selective neck dissection on fresh-frozen cadaveric specimens. Performance was scored by 2 independent, blinded observers using the devised instrument and construct validity was assessed. Results: Through the modified Delphi process a final list of 30 items, considered to be the most essential items for achieving the goals of a level II-IV selective neck dissection, was developed. Construct validity was supported by a positive association between instrument scores compared to both resident postgraduate year level and number of head and neck rotations completed. Conclusion: The development and validation of a novel instrument for assessment of surgical competency in level II-IV selective neck dissection, a key indicator case in otolaryngology, is described. This new instrument may be used to provide objective feedback on overall and task-specific competency to identify surgical deficiencies and offer granular feedback to enhance surgical training.
Vaccination rates against COVID-19 in patients with severe mental illness attending community mental health services in rural Greece
Authors: Peritogiannis Vaios , Drakatos Ioannis , Gioti Panagiota , Garbi Aikaterini 
Published: March 2022

Background: Patients with severe mental illness (SMI) may be at increased risk for COVID-19-related severe morbidity and mortality. There is limited research on the vaccination rates against COVID-19 in patients with SMI. Aims: The objective of the present study is to explore vaccination rates and co-relations in patients with SMI, attending community mental health services, namely the Mobile Mental Health Units (MMHUs) in rural Greece. Method: All treatment engaged patients with SMI (schizophrenia-spectrum or bipolar disorder) with two MMHUs (MMHU of Kefalonia, Zakynthos and Ithaca, [MMHU KZI] and MMHU of the prefectures of Ioannina and Thesprotia [MMHU I-T]) in rural Greece were enrolled prospectively over a six-month period. The MMHU I-T had adopted a more proactive approach to patients’ vaccination, by informing patients and caregivers for its benefits. Results: Data were analyzed for 197 patients with SMI. The overall vaccination rate was 68.5% and did not differ from the respective rates in the general population. There were no differences in vaccination rates among patients attending the two MMHUs, nor among patients with different diagnoses (schizophrenia spectrum disorders or bipolar disorder). Vaccination was not associated with gender, educational level, history of alcohol and substance abuse, illness duration, or number of previous hospitalizations, whereas the effect size of age was moderate. In more than half non-vaccinated patients the refusal to get vaccinated was associated with fears and concerns as well as false beliefs that are encountered in the general population. Conclusion: In the present sample of treatment-engaged rural patients vaccination rates against COVID-19 appear to be satisfactory. There were no differences in vaccination rates with regard to the interventions that were applied to enhance vaccination. It seems that other forms of intervention should be applied to reluctant patients to modify their attitudes toward vaccination.
Windows of repression: Using COVID-19 policies against political dissidents?
Authors: Barceló Joan , Kubinec Robert , Cheng Cindy , Rahn Tiril Høye , Messerschmidt Luca 
Published: March 2022

What explains the great variation in the adoption, timing, and duration of government policies made in response to the COVID-19 pandemic? In this article, we explore whether government incentives to repress domestic dissidents influence their responses to the COVID-19 pandemic. We argue that COVID-19 containment policies are observationally equivalent to those that abusive governments use to limit domestic dissent – that is, policies that restrict citizens’ freedom of movement. This creates an opportunity for abusive governments to engage in repressive behavior without countervailing pressure from citizens and the international community. Following this logic, we expect abusive governments to be more likely to adopt restrictive policies, adopt them earlier in the course of the pandemic, and take longer to relax restrictions. Empirically, we find that governments that have recently engaged in state violence against civilians or abused citizens’ human rights were about 10% more likely to enact lockdown and curfew policies. Compared to less repressive countries, these policies were implemented approximately 48 days earlier in the pandemic and kept in place for approximately 23 days longer. Overall, our results advance our understanding of how the repressiveness of state institutions can shape policy responses to a global health crisis.
Micro foaming performance of scCO2-aid glutaraldehyde/hexametaphosphate/thermoplastic starch foams modified by alkali treatment and montmorillonite nano-platelets
Authors: Wang Ke , Huang Ya-qiong , Cheng Xiao-han , Yeh Jen-taut 
Published: March 2022

The micro foaming performance, moisture resistance and dynamic viscosity of scCO2-aid glutaraldehyde/hexametaphosphate/thermoplastic tapioca starch (GA/SHMP/TOS) foams were considerably improved by proper NaOH treatment. The expansion ratio, resilience rate, dynamic viscosity values of these NaOH modified foams improved to a maximum, as the time for NaOH treatment approached a proper value. The dynamic viscosity, expansion ratio and resilience rate of the scCO2-aid GA/SHMP/TOS foams modified using 110 atm scCO2-pressure, the proper alkali treatment time, SHMP loading and varying montmorillonite (MMT) loadings improved further, as their MMT loadings approached a proper value of 2.5 part per hundred parts of tapioca starch (PHTOS). Relatively large dynamic viscosity (7.1x104 Pa·s), extremely large expansion ratio (∼75), cell density (1.1x109 cells/cm3) and/or resilience rate (∼80%) were acquired for the scCO2-aid GA/SHMP/TOS/MMT foam modified using the proper alkali treatment time and MMT loading. Thermal analyses results showed that crystallization onset temperatures and crystallization rates of scCO2-aid GA/SHMP/TOS/MMT foams modified using the proper alkali treatment time and varying MMT loadings improved to a highest value by adding 2.5 PHTOS of MMT nano-platelets. Possible reasons accounting for the considerably improved micro foaming performance of scCO2-aid GA/SHMP/TOS/MMT foams modified using the proper alkali treatment time and MMT loading are proposed in this study.