bluuebunny/crossref_metadata_2025_split huggingface dataset:
Spontaneous bilateral intraorbital hematoma: A particular form of sickle cell disease complications in children
Authors: Andriamiarintsoa Haritanjona , Ramanandafy Herveat , Andriamiadanalisoa Orlando Andoniaina , Randriantianarisoa Koloina , Randrianarivelo Prosper Harinarivo , Andrianah Emmylou Prisca Gabrielle , Rajaonarison Lova Hasina Ny Ony Narindra , Raobela Léa , Rakotoson Joëlson Lovaniaina , Vololontiana Hanta Marie Danielle , Ahmad Ahmad 
Published: June 2022

AbstractSpontaneous bilateral intraorbital hematoma is a rare complication of sickle cell disease in children. Imaging examinations are of paramount importance in the diagnosis and conditioning of the management processes in order to avoid complications that can compromise the visual function prognosis.
CO2 Stripping from Monoethanolamine through a Polypropylene/CH3SiO2 Composite Hollow‐Fiber Membrane Contactor
Authors: Amirabedi Parya , Akbari Ali , Yegani Reza , Raveshiyan Saba 
Published: June 2022

AbstractTo remove CO2 through a membrane contactor system, composite polypropylene (PP) hollow‐fiber membranes were fabricated by dispersing methyl‐grafted silica nanoparticles in a PP membrane matrix. A set of characterization tests including FTIR spectroscopy, FESEM, AFM, TEM, porosity, contact angle, mechanical strength, and CO2 stripping experiments was carried out. The results showed that the porosity, hydrophobicity, roughness, and CO2 stripping flux of the composite membranes increased with increasing content of inorganic NPs. At an absorbent flow rate of 2.5 m s−1, the CO2 stripping flux of composite membranes containing 1.5 wt % NPs was higher than those of most other hydrophobic membrane contactors.
Herbage accumulation, nutritive value, and persistence of new warm‐season perennial grasses
Authors: de Paula Herico V. G. , Vendramini Joao M. B. , Sollenberger Lynn E. , Moriel Philipe , Siqueira da Silva Hiran Marcelo , Garzon Jaime Eduardo , de Oliveira Hugo M. R. , Machado Igor M. , dos Santos Antonio C. 
Published: June 2022

Abstract‘Camello’ brachiariagrass (Urochloa spp.) and Spain guineagrass [Megathyrsus maximus (Jacq.) B.K. Simon & S.W.L. Jacobs] are new warm‐season perennial forages with potential for use in subtropical livestock production systems. There are no data in the United States describing their agronomic performance. This study aimed to evaluate the herbage accumulation (HA) and nutritive value of Camello and Spain in north‐central (Citra) and south (Ona) Florida. Experiments were conducted from April to October in 2019 and 2020. Treatments were four warm‐season grasses: Spain guineagrass, Camello brachiariagrass, ‘Mombaça’ guineagrass (not included at Ona), and Jiggs bermudagrass [Cynodon dactylon (L.) Pers.] distributed in a randomized complete block design with four replicates. In Ona, Camello and Spain had similar HA but outyielded Jiggs. Jiggs had greater crude protein (CP) than Camello and Spain during summer but less in vitro digestible organic matter (IVDOM). After 2 yr, there was no difference in groundcover among genotypes at Ona. In Citra, Spain had the greatest HA, followed by Camello and Mombaça, with Jiggs having the least. Jiggs had the greatest CP concentration among the grasses but less IVDOM. Camello, Spain, and Mombaça had generally similar IVDOM, with few differences among months. After 2 yr at Citra, Jiggs had the greatest groundcover, followed by Camello. Mombaça and Spain had the least and did not persist after the 2020–2021 winter. Camello and Spain are promising warm‐season perennial grasses for lower subtropical latitudes, but in the cooler subtropics, the longevity of Spain stands is compromised by frequent winter freezing.
Release of bitumen from mature fine tailings in the presence of a polymeric dispersant
Authors: Alizadeh Hamid , MacIver Michael R. , Pawlik Marek 
Published: June 2022

AbstractThe effect of the addition of a polymeric dispersant, sodium lignosulphonate (LS), on the dispersion of mature fine tailings (MFT) was studied using zeta potential and total organic carbon measurements. Three different types of LSs were investigated to determine the importance of molecular weight and level of anionicity of LSs on the treatment of MFT. The presence of two fractions of bitumen was identified in the tested MFT sample. A small portion of bitumen was found to occur in the form of weakly held aggregates between bitumen and fine solids. This fraction was easily dispersed by small dosages of LS, resulting in bitumen liberation to the tailings surface. A much larger amount of bitumen was found to be strongly attached to the solids, and only very high dosages of LS were capable of partly liberating this fraction. The zeta potential promoted an understanding of the mechanism of adsorption of LS on the particles and liberation of bitumen from MFT. Carbon measurements facilitated determination of the adsorption density of the selected types of LS on solid particles.
DPP‐4 inhibitor linagliptin ameliorates imiquimod‐induced psoriasis‐like skin alterations in type 2 diabetic mice by inhibiting the MAPK/NF‐κB inflammatory pathway
Authors: Shao Zhulin , Li Xiaohong , Xu Xiangjin , Chen Pin 
Published: June 2022

AbstractStudies have shown that the DPP‐4 inhibitor was effective in improving skin damage in patients with psoriasis, but the exact mechanism was not known. To investigate the therapeutic effects of linagliptin in mice with type 2 diabetes mellitus (T2DM) with psoriasis and its possible therapeutic mechanisms. A total of 32 db/db mice and 16 db/m mice were randomly divided into six groups: normal group, psoriasis group, diabetes group, diabetes combined with psoriasis group, linagliptin‐treated diabetes group, and linagliptin‐treated diabetes combined with psoriasis group. The levels of serum fasting blood glucose, total cholesterol (TC), triglyceride (TG), high‐density lipoprotein cholesterol, and low‐density lipoprotein cholesterol were measured; the levels of serum FINS were determined by enzyme‐linked immunoassay and the insulin resistance index was calculated. Basic parameters of diabetes, Psoriasis Area and Severity Index, histopathology of skin, the expression of interleukin (IL)‐17A, IL‐23, IL‐22, and tumor necrosis factor (TNF)‐α, and expression levels of measuring p‐ERK, p‐MAPK and p‐nuclear factor kappa B (NF‐κB) in skin tissues were measured. After treatment with linagliptin, insulin resistance, and TC and TG levels were reduced in mice with T2DM and psoriasis (p < .05). Moreover, the degree of epidermal tissue thickening, number of keratinized layers, and inflammatory cell infiltration were also reduced (p < .05), as well as the expression levels of inflammatory factors: TNF‐α, IL‐1β, IL‐17A, IL‐23, and p‐P38/P38, p‐ERK/ERK, p‐P65/P65 proteins (p < .05). Linagliptin significantly reduced the extent of skin lesions and skin inflammation. The underlying mechanism of this compound may be related to the inhibition of MAPK/NF‐κB inflammatory pathways and the consequential improvement of insulin resistance.Significance Statement: In this study, we evaluated the therapeutic effect of the DPP‐4 inhibitor linagliptin using a murine model of type 2 diabetes combined with psoriasis, and its potential mechanisms of action were further explored. The results of this study will help to uncover the pathogenesis of type 2 diabetes and psoriasis and, more importantly, provide a theoretical basis for the search for safe and effective drugs in the treatment of this specific patient population.
Design, synthesis, and biological evaluation of thienopyrimidine and thienotriazine derivatives as multitarget anti‐Alzheimer agents
Authors: Eissa Kholoud I. , Kamel Mona M. , Mohamed Lamia W. , Galal Mai A. , Kassab Asmaa E. 
Published: June 2022

AbstractA series of tetrahydrobenzothienopyrimidines and tetrahydrobenzothienotriazines incorporating a pharmacophore from donepezil molecule were designed and synthesized. The 12 newly synthesized compounds were screened for their inhibition activity against acetylcholinesterase enzyme (AChE). Compounds that exerted the most potent AChE inhibitory action were further evaluated for their BChE inhibitory activity. In addition, the inhibitory effects of all newly synthesized compounds on Aβ and reactive oxygen species were assessed. Compounds 4d, 10b, and 10c showed potent inhibitory activity on AChE comparable to donepezil. Compound 10b (IC50 = 0.124 ± 0.006 nM) showed the greatest AChE inhibitory action and the most potent BChE inhibitory action (IC50 = 0.379 ± 0.02 nM). These three compounds showed more inhibitory action on Aβ accumulation than donepezil. Moreover, they showed potent antioxidant activity. The binding pattern of compounds 4d and 10b into AChE active site rationalized their remarkable AChE inhibitory activity. Taken together, these results indicated that these derivatives could be promising multifunctional agents for Alzheimer's disease management.
Downregulation of CPT1A exerts a protective effect in dextran sulfate sodium‐induced ulcerative colitis partially by inhibiting PPARα signaling pathway
Authors: Chen Wenxiao , Zou Jinyan , Shi Xinyuan , Huang Huifeng 
Published: June 2022

AbstractUlcerative colitis (UC) is a chronic inflammatory bowel disease that may progress to colorectal cancer in severe cases. Carnitine palmitoyltransferase‐1A (CPT1A) has been reported to be upregulated in colorectal cancer. This paper aims to explore the role of CPT1A in UC and its pathogenesis. An in vivo mice model of UC was constructed by administrating 3% dextran sulfate sodium (DSS). The expression level of CPT1A was examined by quantitative real‐time polymerase chain reaction and Western blot. The intestinal damage, inflammatory response and oxidative stress were assessed by hematoxylin and eosin staining, colon length, and commercial kits. Thereafter, an in vitro cell model of UC was established by stimulating HT‐29 cells with 2% DSS. The peroxisome proliferator‐activated receptor α (PPARα) signaling agonist GW7647 was used for treatment. Cell viability and apoptosis was assayed by cell counting kit‐8 assay and terminal dUTP nick‐end labeling assay, respectively. The inflammatory cytokines and oxidative stress‐related factors was evaluated using corresponding commercial detection kits. In DSS‐induced mice model of UC, CPT1A expression was upregulated. Interference of CPT1A attenuated histological damage, the disease activity index and colon length in colitis. We also found downregulation of CPT1A inhibited inflammatory response and oxidative stress, and inhibited PPARα signaling pathway in UC mice. Additionally, in DSS‐induced HT‐29 cells, downregulation of CPT1A promoted cell viability, reduced cell apoptosis, inflammatory response, and oxidative stress, which was partly abolished by additional treatment with GW7647. In summary, downregulation of CPT1A exerts a protective effect in DSS‐induced UC partially through suppressing PPARα signaling, suggesting that CPT1A might be a potential target for the treatment of UC.
Trazodone and patient outcomes in dementia—Limitations of naturalistic cohort data
Authors: Sidhom Emad , Padilla Mc Stephen , Lewis Jonathan , White Simon , O’Brien John T. , Mallucci Giovanna R. , Underwood Benjamin R. 
Published: June 2022

AbstractThe unfolded protein response has been increasingly implicated as an important pathological pathway and target for therapeutic intervention in neurodegeneration. The licensed antidepressant trazodone is one drug which has been proposed to act on this pathway and may therefore be a potential therapy. Previous examination of existing data for patients with dementia prescribed trazodone did not find a signal suggesting a disease modifying effect. Here we add to that literature by examining the electronic patient record of patients with dementia in Cambridgeshire UK. We found that trazodone is rarely prescribed and where it is used it is at a dose less than half that predicted to be disease modifying. We also found that patients prescribed trazodone had higher levels of neuropsychiatric symptoms and were relatively late in the disease course, likely beyond the optimal point for therapeutic intervention. We suggest it is therefore premature to discard potential therapies based on observational data alone, particularly when experimental medicine approaches to examine the effects of trazodone are feasible.
Robot‐assisted laparoscopy repair of uterine isthmocele: A two‐center observational study
Authors: Cardaillac Claire , Salmon Caroline , Vaucel Edouard , Gueudry Pauline , Lavoue Vincent , Nyangoh Timoh Krystel , Thubert Thibault 
Published: June 2022

AbstractObjectiveTo analyze outcomes and postoperative complications in patients undergoing robot‐assisted isthmocele repair.MethodThis retrospective cohort study included 33 patients who had robot‐assisted laparoscopic surgical management of an isthmocele between September 2013 and August 2020 in two French university hospitals. All charts were reviewed to identify patient characteristics, preoperative and postoperative anatomical findings, complications, and postoperative fertility and symptoms. Patients who had undergone this procedure were asked to complete a telephone questionnaire about their treatment satisfaction and symptoms.ResultsThe isthmocele was discovered most often as a result of subfertility (57.6%), but also ectopic pregnancy (18.2%), pelvic pain (15.2%), and postmenstrual bleeding (9.1%). Robot‐assisted repair of the isthmocele significantly improved myometrial thickness (from 1.55 mm before surgery to 4.26 mm after surgery [mean difference 2.71; 95% confidence interval, 1.91–3.51], P = 0.0005). Among 20 patients who still desired a child after surgery, 15 became pregnant and 14 had full‐term live births. Among the nine patients who had surgery for disabling symptoms, five had no persistent symptoms, three reported global improvement, and one had the same gynecologic discomfort. Seventeen patients agreed to complete the questionnaires (51.5%), and all stated that they would choose to have this surgery again.ConclusionRobot‐assisted repair of an isthmocele is a viable minimally invasive procedure.
Survey of critical care practices for alcohol withdrawal syndrome in the intensive care unit
Authors: Cucci Michaelia D. , Palm Nicole , Vazquez Daniel , Mullen Chanda , Heavner Mojdeh S. 
Published: June 2022

AbstractIntroductionAlcohol use disorder affects up to 60% of intensive care unit (ICU) patients. Alcohol withdrawal syndrome (AWS) is associated with increased length of stay, mechanical ventilation, and mortality. The lack of clinical practice guidelines specific to ICU patients leads to ambiguity about the standard management of AWS in this population.ObjectivesThe aim of this study was to describe current practice patterns employed for AWS management in ICU settings across the United States.MethodsThis was a cross‐sectional survey of practicing critical care pharmacists identified via a pharmacy professional organization critical care listserv. Emails were sent four times to the recipient list from May 14, 2021 to June 25, 2021. Retired pharmacists and trainees on the listserv were excluded. The survey was conducted by REDCap and descriptive statistics were performed.ResultsThere were a total of 144/1534 (9.4%) responses. Predominant characteristics included university hospital settings (n = 71/143, 49.7%) with greater than 75 ICU beds (n = 54/144, 37.5%), and medical (n = 53/144, 36.8%) or mixed (n = 52/144, 36.1%) ICU populations. The majority reported having an institutional AWS guideline (n = 96/140, 68.6%). A total of 139/143 (97.2%) preferred benzodiazepines, with lorazepam (n = 136/143, 97.8%) as the primary benzodiazepine agent. Most preferred lorazepam as needed, rather than preemptively (n = 137/138, 99.3%). Phenobarbital use was reported by 82.6% (n = 119/144) of respondents, primarily for treatment of benzodiazepine‐refractory withdrawal (n = 96/117, 82.1%). Similarly, dexmedetomidine use was reported by 86.1% (n = 124/144) of respondents, primarily for refractory withdrawal (n = 48/121, 39.7%). Propofol was primarily preferred for patients on mechanical ventilation (n = 56/98, 57.1%) or refractory withdrawal (n = 51/98, 52.0%). Clonidine was preferred by 45.8% (n = 66/144) and atypical antipsychotics by 33.6% (n = 48/143) of respondents.ConclusionsMost ICU pharmacists prefer symptom‐triggered benzodiazepines first line, followed by propofol in intubated patients and dexmedetomidine and/or phenobarbital for refractory cases. Clinical practice guidelines may help provide guidance for the management of these patients.
Ultrasound and magnetic resonance imaging features of fetal intracranial cystic lesions: A pictorial essay
Authors: Moradi Behnaz , Golezar Mohammad Hossein , Saleh Gargari Soraya , Kazemi Mohammad Ali , Golezar Samira , Taheri Morteza Sanei , Tahmasebpour Ahmad‐Reza 
Published: June 2022

AbstractThis pictorial essay focuses on ultrasound (US) and magnetic resonance imaging (MRI) features of fetal intracranial cysts. Intracranial cysts are common findings in prenatal imaging, and if great attention is paid to their size, location, and imaging features, they can be diagnosed accurately. They are usually detected by fetal ultrasound exams. However, when ultrasound data on cystic lesion characteristics is insufficient, MRI and fetal neurosonogram are the best options for detecting other associated anomalies. The prognosis is highly dependent on their location and whether they are associated with other fetal anomalies.
Inactivating BTK mutations in large B‐cell lymphoma in a real‐world cohort: Strong correlation with BCL2 translocation
Authors: Schejbel Lone , Breinholt Marie Fredslund , Gang Anne Ortved , Nielsen Torsten Holm , Pedersen Lars Møller , Høgdall Estrid , Nørgaard Peter 
Published: June 2022

AbstractInactivating mutations in Bruton's tyrosine kinase (BTK) in patients with follicular lymphoma (FL) have recently been reported. These mutations were found in BTK inhibitor‐treatment naïve patients. Here, we report the BTK mutation status in a real‐world cohort of patients with non‐Hodgkin lymphoma. We found primary BTK mutations in 7.7% of patients with large B‐cell lymphoma (LBCL) and in 14.1% of patients with FL. All patients with BTK‐mutated LBCL were BCL2 translocation positive, and the correlation between BCL2 translocation and BTK mutation persisted even when patients with known transformation from FL were excluded.
A meta‐analysis of the association between shame and dissociation
Authors: Rudy Justine A. , McKernan Scott , Kouri Nicole , D'Andrea Wendy 
Published: June 2022

AbstractShame and dissociation have been implicated theoretically and empirically in trauma exposure and its sequelae, with shame understood as an intense negative emotion and dissociation as a reaction to intense negative emotions. Understanding the connection between shame and dissociation is important for theory and practice; however, the strength of this association remains unclear. For example, in therapy, both shame and dissociation serve as a barrier to engaging with emotion. Theoretically, these two states should be distinct, as one (dissociation) confers low affective intensity and the other (shame) high intensity. The present meta‐analysis focused on the magnitude of the association between these two phenomena and investigated the extent to which gender, trauma exposure, psychiatric comorbidities, and demographic characteristics influence this association given their independent links to shame and dissociation. An initial search of six databases identified 151,844 articles. Duplicates were removed, and additional articles were excluded based on abstract and title screening. After contacting authors for missing data, a full‐text screen yielded 25 articles for the present analysis. The results indicate that shame and dissociation were moderately correlated (k = 33, n = 4,705), r = .42, 95% CI [.35, .48], p < .001, but no clear clinical moderators emerged. Despite this association, very few studies utilized experimental designs to examine the association between these constructs. Future research should focus on experimental study designs to investigate the extent to which shame induces dissociation or vice versa.
Revealing the scale‐ and location‐specific variation and control factors of soil salinity using bi‐dimensional empirical modal decomposition
Authors: Zhu Chuanmei , Ding Jianli , Zhang Zipeng 
Published: June 2022

AbstractThe key to saline land management and soil salinity control is to clarify the dynamics of soil salinity and the characteristics of environmental factors. However, due to the high heterogeneity of soil salinity, the influence of environmental factors on soil salinity variation at specific scales and locations is still unclear. The purpose of this study is to reveal the variability characteristics and controlling factors of soil salinity in the Wei‐Ku Oasis during different seasons. One hundred and eighty‐two topsoil samples (0–20 cm) were acquired during the irrigation and non‐irrigation seasons (IRRS and NIRRS) in the study area. This study predicted soil surface salinity at 90 m spatial resolution from randomForest (RF) models and measured data. Based on the mapping, a bi‐dimensional empirical modal decomposition (BEMD) algorithm was applied to extract the variation of the soil salinity at different scales and locations in the IRRS and NIRRS. Subsequently, correlation analysis, semi‐variance functions, and redundancy analysis were applied to dissect the correlation and main control factors between soil salinity and the environment at three different scales. The results indicated that soil salinity was greater in the NIRRS at the Weiku Oasis. Soil salinity was decomposed into five intrinsic modal functions with spatial variability scales of 6.20–50.61 km and 7.93–50.18 km during the IRRS and NIRRS, respectively. The relationships between environmental factors and soil salinity were scale‐ and location‐specific, suggesting a complex interrelationship between topography, temperature, vegetation cover, and soil salinity. The normalized difference vegetation index was found to be the main factor affecting small‐scale seasonal variation in soil salinity, whereas the large‐scale spatial distribution of soil salinity was most affected by evapotranspiration and temperature. These findings highlight the effectiveness of BEMD in revealing the scale and location control of soil salinity.