bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nanoanyagok humánbiztonsági kockázatot jelentő tulajdonságainak bemutatása és csoportosítása
Authors: Járdán Eszter , Dr. Zákányiné Dr. Mészáros Renáta 
Published: January 2022

A nanoanyagok egyedi tulajdonságaik révén egyre szélesebb körű felhasználásnak örvendenek, amelyeknek köszönhetően számos iparág tevékenységében fellelhetők, térhódításuk továbbra is növekvő tendenciát mutat. Az ipari felhasználásuk az utóbbi néhány évtizedben lett számottevő. Ezen robbanásszerű fejlődés következtében hiányos ismeretekkel rendelkezünk az anyagok élő szervezetekre, valamint az emberi egészségre gyakorolt pontos hatásmechanizmusát illetően mind rövid-, mind pedig hosszútávon. A nanoanyagok számos különböző megjelenési formájukból, változatos fizikai és kémiai tulajdonságaikból adódóan különböző módokon juthatnak be az élő szervezetekbe, majd tovább a véráramba, a nyirokrendszerbe elérve az egyes szerveket és ott különböző egészségkárosító hatásokat előidézve súlyos megbetegedéseket okozhatnak. Hazánkban és az Európai Unióban jogi szabályozások tekintetében az érintett tématerület lefedettsége kezdetlegesnek mondható. Az anyagoknak való kitettség kockázatának vizsgálatához szintén nem áll rendelkezésünkre, olyan összefoglaló anyag, amely részletesen kitérne az egyes kockázati tényezőkre, vizsgálandó paraméterekre. Munkánk során célunk volt egy olyan szempontrendszer kialakítása, amely figyelembe veszi a nanoanyagok használata, illetve a velük való érintkezés során felmerülő kockázatokat az anyagok egyes tulajdonságai alapján - legyen az fizikai, kémiai vagy biológiai- , amely szempontrendszer a későbbiekben megfelelő kiindulási alapot biztosíthat a munkavédelmi kockázatértékelések elkészítése alkalmával, ezáltal biztonságosabbá téve az ezen anyagokkal való munkavégzést, a munkát végzők és a munkavégzés hatókörében jelenlévők számára egyaránt.
Classes multisseriadas em escolas da roça: Lócus das práticas contextualizadas pela diferença
Authors: Mota Charles Maycon de Almeida , Silva Fabricio , Rios Jane Adriana 
Published: January 2022

O estudo busca compreender como as práticas docentes são desveladas e se constituem como modos de narrar, fazer e formar-se nas acontecências da profissão docente, evidenciando como professores e professoras lidam com a diferença em classes multisseriadas nas escolas da roça. A pesquisa desenvolveu-se a partir de narrativas de formação de três professores e duas professoras que moram em comunidades rurais do município de Várzea do Poço/BA, interior da Bahia-Brasil. São, portanto, docentes que atuam na Educação Básica, desenvolvendo a docência em classes multisseriadas de escolas da roça. Como dispositivos de recolha de informações, foram desenvolvidas Oficinas Formativas, inspiradas na proposta dos Ateliês Biográficos de Delory-Momberg (2006). As oficinas constituíram-se enquanto espaços de produção das narrativas. Este estudo está fundamentado na abordagem (auto)biográfica com base na pesquisa qualitativa, tomando as narrativas como um dispositivo de investigação e formação na/da docência em escolas da roça. Conclui-se que a experiência é um dos elementos principais da produção da docência em classes multisseriadas das escolas da roça, em que modos de narrar, fazer e formar-se, são condições para a produção da docência nestes espaços. Concluiu-se, ainda que as propostas de contextualização das aulas colaboram para dar centralidade às diferenças nas escolas da roça.
"Two Styles More Opposed"
Authors: Gustin Melissa L. 
Published: January 2022

This paper explores how Harriet Hosmer (1930-1908) positioned two early busts, Daphne (1853/4) and Medusa (1854) in opposition to Gianlorenzo Bernini's works of thes same subject through careful deployment of Winckelmannian principles. This engages with the first English translation of Winckelmann's History of the Art of Antiquity by Giles Henry Lodge in 1850, as well as the rich body of antique material available to Hosmer in Rome. It problematises art historical approaches to Hosmer's work that emphasise biographically-led readings over object-led interpretations informed by contemporary translations, discourses of originality, and display practices. It demonstrates the conflicting position of Bernini in the middle and late nineteenth century as the "Prince of Degenerate Sculpture", and shows that Winckelmann's victimisation of Bernini led to his poor reputation. This reputation as skilled but degenerate provided the foil for Hosmer to reclaim these subjects, demonstrate her correct understanding of classical principles and citation, and prove her superiority. Ultimately, however, the two artists will be shown to have more similarities than differences in their use of classical references; only access to Winckelmann's writings separates their reception in the nineteenth century.
Efektivitas ice breaking dalam mengurangi kejenuhan peserta didik mempelajari Bahasa Arab
Authors: Desmidar Desmidar , Ritonga Mahyudin , Halim Syaflin 
Published: January 2022

Kondisi pembelajaran yang statis dipandang tidak proporsional karena menyebabkan peserta didik merasa terbebani, bosan dan jenuh. Kejenuhan belajar didefinisikan sebagai kelelahan fisik, emosional, dan mental yang dialami oleh siswa yang ditandai dengan penurunan motivasi dan minat peserta didik dalam pembelajaran, motivasi dan minat yang rendah dapat mengakibatkan penurunan prestasi belajar siswa. Kejenuhan belajar terjadi karena proses belajar siswa dilakukan secara terus menerus dan untuk waktu yang lama namun tidak mendapatkan kesuksesan. Tujuan dari penelitian ini adalah untuk menguji efektivitas ice breaking dalam mengurangi kejenuhan peserta didik pada saat pembelajaran. Penelitian ini menggunakan pendekatan kuantitatif dengan desain eksperimen semu. Sampel penelitian tersebut adalah peserta didik kelas VIII.1 MTs Negeri 2 Pasaman, yaitu 41 orang. Hasil penelitian menunjukkan bahwa ada penurunan skor rata-rata kejenuhan siswa sebesar 19,07. Pembelajaran dengan menggunakan ice breaking membuat proses pembelajaran mengalami peningkatan kualitas dan hilangnya kejenuhan peserta didik sebesar 15,31%. Rekomendasi kepada guru agar kreatif menciptakan suasana belajar yang menarik dan menyenangkan, salah satunya dengan menerapkan permainan ice breaking dalam proses pembelajaran agar proses pembelajaran menjadi lebih optimal.The demands of learning and teaching and learning activities that menoton judged disproportionate so as to make students feel burdened, bored and saturated. Learning saturation is defined as physical, emotional, and mental fatigue experienced by students characterized by decreased motivation and interest in student learning, which can result in decreased student learning achievement. The saturation of learning occurs because the learning process of students is done continuously and for a long time but does not get success. The purpose of this study is to test the effectiveness of ice breaking to reduce the saturation of students' learning. The research uses quantitative approach with quasi experimental design non equivalent pretest post test control group. The research sample was grade VIII.1 MTsN 2 Pasaman students, which is 41 people. The results showed that there was a decrease in the average score of student saturation of 19.07. A significant change in learning saturation score of 15.31%. Recommendations to teachers in order to creatively create an interesting and fun learning atmosphere, one of which is by applying ice breaking games in the learning process so that the learning process becomes more optimal.
A Smartphone App for Attentional Bias Retraining in Smokers: Mixed Methods Pilot Study
Authors: Choo Carol C , Tan Yi Zhuang , Zhang Melvyn W B 
Published: January 2022

Background
Smoking is a global health threat. Attentional bias influences smoking behaviors. Although attentional bias retraining has shown benefits and recent advances in technology suggest that attentional bias retraining can be delivered via smartphone apps, there is a paucity of research on this topic.

Objective
This study aims to address this gap by exploring the use of attentional bias retraining via a novel smartphone app using a mixed methods pilot study. In the quantitative phase, it is hypothesized that participants in the training group who undertake attentional bias retraining via the app should have decreased levels of attentional bias, subjective craving, and smoking frequency, compared with those in the control group who do not undertake attentional bias retraining. The qualitative phase explores how the participants perceive and experience the novel app.

Methods
In all, 10 adult smokers (3 females and 7 males) between the ages of 26 and 56 years (mean 34.4 years, SD 9.97 years) were recruited. The participants were randomly allocated to the training and control groups. In weeks 1 and 3, participants from both groups attempted the standard visual probe task and rated their smoking frequency and subjective craving. In week 2, the participants in the training group attempted the modified visual probe task. After week 3, participants from both groups were interviewed about their views and experiences of the novel app.

Results
The results of the quantitative analysis did not support this study’s hypothesis. The qualitative data were analyzed using thematic analysis. The results yielded 5 themes: ease, helpfulness, unhelpful aspects, barriers, and refinement.

Conclusions
Findings from the qualitative study were consistent with those from previous studies on health-related smartphone apps. The qualitative results were helpful in understanding the user perspectives and experiences of the novel app, indicating that future research in this innovative area is necessary.
The Use of Telehealth for Psychological Counselling of Vulnerable Adult Patients With Rheumatic Diseases or Diabetes: Explorative Study Inspired by Participatory Design
Authors: Rothmann Mette Juel , Mouritsen Julie Drotner , Ladefoged Nanna Skov , Jeppesen Marie Nedergaard , Lillevang Anna Sofie , Laustrup Helle , Ellingsen Torkell 
Published: January 2022

Background
Video consultation is increasingly used in different health care settings to reach patients. However, little is known about telehealth in psychological counselling for vulnerable patients with somatic and chronic conditions such as rheumatoid arthritis and diabetes.

Objective
This study aimed to develop and pilot test a telepsychology module for inclusion in the app My Hospital (Mit Sygehus) to provide remote psychological counselling to vulnerable adults with either rheumatic diseases or diabetes.

Methods
With inspiration from participatory design, the content of the telepsychology module was developed through user involvement and evaluated by individual interviews with patients and psychologists as well as questionnaires.

Results
We developed a module with our patient partners that targeted patients with rheumatic diseases and diabetes in relation to the psychological challenges of living with chronic diseases. The module included information, tools, exercises, and videoconferencing. In total, 16 patients and 3 psychologists participated in the pilot test. Psychological counselling was described by 4 themes: “The good relation despite physical distance,” “The comfort of being at home,” “The pros of saving time on transport and energy,” and “A therapeutic alliance at a distance.”

Conclusions
Psychological counselling in relation to somatic care can be provided by videoconferencing supported by web-based or mobile delivery of tailored information, tools, and exercises without compromising on the quality of care. To ensure a good alliance between the patient and psychologist, a first face-to-face meeting is important. The home location provided patients with a safe environment and increased accessibility and reduced travel time to the hospital.
Multisensory Home-Monitoring in Individuals With Stable Chronic Obstructive Pulmonary Disease and Asthma: Usability Study of the CAir-Desk
Authors: Kohlbrenner Dario , Clarenbach Christian F , Ivankay Adam , Zimmerli Lukas , Gross Christoph S , Kuhn Manuel , Brunschwiler Thomas 
Published: January 2022

Background
Research integrating multisensory home-monitoring in respiratory disease is scarce. Therefore, we created a novel multisensory home-monitoring device tailored for long-term respiratory disease management (named the CAir-Desk). We hypothesize that recent technological accomplishments can be integrated into a multisensory participant-driven platform. We also believe that this platform could improve chronic disease management and be accessible to large groups at an acceptable cost.

Objective
This study aimed to report on user adherence and acceptance as well as system functionality of the CAir-Desk in a sample of participants with stable chronic obstructive pulmonary disease (COPD) or asthma.

Methods
We conducted an observational usability study. Participants took part in 4 weeks of home-monitoring with the CAir-Desk. The CAir-Desk recorded data from all participants on symptom burden, physical activity, spirometry, and environmental air quality; data on sputum production, and nocturnal cough were only recorded for participants who experienced symptoms. After the study period, participants reported on their perceptions of the usability of the monitoring device through a purpose-designed questionnaire. We used descriptive statistics and visualizations to display results.

Results
Ten participants, 5 with COPD and 5 with asthma took part in this study. They completed symptom burden questionnaires on a median of 96% (25th percentile 14%, 75th percentile 96%), spirometry recordings on 55% (20%, 94%), wrist-worn physical activity recordings on 100% (97%, 100%), arm-worn physical activity recordings on 45% (13%, 63%), nocturnal cough recordings on 34% (9%, 54%), sputum recordings on 5% (3%, 12%), and environmental air quality recordings on 100% (99%, 100%) of the study days. The participants indicated that the measurements consumed a median of 13 (10, 15) min daily, and that they preferred the wrist-worn physical activity monitor to the arm-worn physical activity monitor.

Conclusions
The CAir-Desk showed favorable technical performance and was well-accepted by our sample of participants with stable COPD and asthma. The obtained insights were used in a redesign of the CAir-Desk, which is currently applied in a randomized controlled trial including an interventional program.
REVIEW ON FORMULATION AND EVALUATION OF SOLID LIPID NANOPARTICLES FOR VAGINAL APPLICATION
Authors: PRIYANKA PALLERLA , SRI REKHA M. , DEVI A. SEETHA 
Published: January 2022

Vaginal drug administration can improve prophylaxis and treatment of many conditions affecting the female reproductive tract, which includes fungal and bacterial infections, sexually transmitted diseases and cancer also. This is the best route for the administration of proteins, peptides, and also other therapeutic drugs like macro-molecules. For the administration of drugs like contraceptives, steroids, metronidazole, anti-retroviral, vaginal drug delivery is the most preferable route. However, achieving sufficient drug concentration in the vagina can be challenging because of its low permeability. The benefits of the vaginal drug delivery system are it increases the bioavailability, least systemic side effects; easiness of use and self-medication is possible. However vaginal drug delivery system is considered as a less effective route because of the unfortunate absorption of drugs across the vaginal epithelium. The traditional commercial preparations, such as creams, foams, gels, irrigations and tablets, are known to reside in the vaginal cavity for a relatively short period of time owing to the self-cleaning action of the vaginal tract and often require multiple daily doses to ensure the desired therapeutic effect. With the rapidly developing field of nanotechnology, the use of specifically designed carrier systems such as Nanoparticle-based drug delivery has been proven an excellent choice for vaginal application to overcome the challenges associated with the low permeability.
TRENDS IN PRESCRIPTION PATTERN IN MEDICAL INDIAN ICU AND IT’S IMPACT ON PATIENT OUTCOME
Authors: RAMAN KOLA VENKAT , HEMASREE MEDA , KISHORE SHARON ROSE 
Published: January 2022

Objective: The objective of this study is to evaluate the trends in prescribing pattern in medical ICU concerning patient age, gender, past, and current illness along with comorbidities for the evasion of polypharmacy and to improve patient outcomes.
Methods: A prospective analysis of the case records of patients admitted to the ICU of Yashoda hospital in India was carried out.
Results: 120 patients were evaluated, consisting of 77% male patients. The mean±SD of age is 53.81±14.63. The majority of the study subjects belonged to the age group of 50-67 y (32%) Most common causes for admission to the ICU were Respiratory diseases and Stroke. Diabetes mellitus and Hypertension are the most common co-morbidities identified. The total number of drugs used were 1502 during this study period. The average number of drugs per prescription is 12. The range is between 2-30. The average number of antibiotics per prescription is 3. Commonly prescribed drug classes were the GI agents in 100% of patients, followed by antimicrobial agents (AMAs) in 95.8% of patients. About 42.5% of patients received 3 antibiotics per day. 55 potential drug-drug interactions were interpreted in 46 patients. 30(55%) were moderate interactions 25(45%) were major interactions, which were addressed. De-escalation of antibiotics was seen in 29% of patients while escalation in 13%. The death rate is only 5% in our ICU setting.
Conclusion: This prescription pattern study can provide a framework for continuous prescription audit in the ICU
ANALISIS PRAKTIK PENGUNGKAPAN INTELLECTUAL CAPITAL STUDI PADA PERUSAHAAN SUB SEKTOR INDUSTRI OTOMOTIF
Authors: Kholmi Masiyah , Wahyuni Endang Dwi , Heni Febri 
Published: January 2022

The aim of this study is to analyze the intellectual capital disclosure practices by Indonesian automotive industry. Content analysis was used to analyze the annual report for one the year 2016. This research used Guthrie at., el. scheme of intellectual capital components. In this scheme, IC was categorized into 3 groups; relational competence (human capital: 8th items).internal structures (organizational capital: 15th items); and external structures (customer/relational capital: 13th items); The result shows that percentage of IC disclosure by Indonesian automotive industry was high relatively In 2016, there were some attributes that not disclosed yet by a company, it was ’copyright’. There was no company that discloses all of the 36th components of IC in their annual report. The maximum number of the attribute that disclosed by a company was 31.
Drug Therapy for Non-Alcoholic Steatohepatitis-Induced Liver Fibrosis
Authors: Garbuzenko D. V. 
Published: January 2022

Aim. An overview of current pharmacotherapy for non-alcoholic steatohepatitis (NASH)-associated liver fibrosis.Key points. In current clinical recommendations, therapeutic measures in non-alcoholic fatty liver disease should include lifestyle change, body weight normalisation, NASH-associated liver fibrosis-specific drug therapy and treatment for metabolic syndrome-related diseases. Given a lack of approved antifibrotic therapies in NASH, several drugs have nevertheless demonstrated an adequate efficacy and safety in phase 3 clinical trials, also in compensated cirrhosis, which allows their practical validation in phase 4.Conclusion. The understanding of liver fibrosis as an adverse natural consequence of non-alcoholic fatty liver disease clearly attests for an early introduction and wide use of antifibrotic therapy to improve NASH outcomes and avoid associated complications.
Diagnostic Algorithm for Joint Pain in Patients with Inflammatory Bowel Disorders
Authors: Dolgushina A. I. , Khusainova G. M. , Nesmeyanova O. B. , Kirsh N. V. , Solovieva O. V. , Bogdanova E. A. 
Published: January 2022

Aim. An algorithm development for joint pain differential diagnosis in patients with inflammatory bowel disorders (IBD) and its validation in clinical practice.Materials and methods. A total of 349 IBD patients hospitalised for gastroenterological complaints at the Chelyabinsk Regional Clinical Hospital during 2017–2020 have been examined.Results. Upon survey, 97 (27.8%) IBD patients complained of joint pain. Ulcerative colitis (UC) predominated (79 patients; 81.4%), Crohn’s disease (CD) had a 18.6% incidence. In survey, 27% UC and 32.1% CD patients reported joint pain (p = 0.26). Among IBD patients, 52.6% had mechanical, and 47.4% — inflammatory pain. The inflammatory back pain (IBP) rate in survey cohort was 23.7%. Use of a diagnostic algorithm allowed concomitant rheumatic disease detection in 7 (7.2%) patients from the IBD–joint pain cohort: 2 patients were diagnosed with psoriatic spondyloarthritis, 2 — rheumatoid arthritis, 1 — gout and 2 — with ankylosing spondylitis. IBD-associated arthritis was diagnosed in 41 (42.3%) cases, osteoarthritis — in 38 (39.2%) IBD patients with joint pain, arthralgia with no objective inflammation, impaired joint function or lesions in X-ray and/or ultrasound — in 13 (13.4%) patients.Conclusion. Joint pain complaints are common in IBD patients and require a multispecialty rheumatologists-involving approach to proceed with differential diagnosis and opting for treatment tactics. A clinically verified algorithm coupled with laboratory tests and instrumental imaging facilitates diagnosis and optimal therapy selection in IBD patients with complaints of joint pain.
Colorectal Cancer in Patient with Functional Gastrointestinal Symptoms
Authors: Mamieva Z. A. , Poluektova E. A. , Kovaleva A. L. , Shifrin O. S. , Sobolev V. P. , Svistushkin V. M. , Ulyanin A. I. , Tertychnyy A. S. , Ivashkin V. T. 
Published: January 2022

Aim. A clinical observation to highlight the importance of detailed examination in patients with functional gastrointestinal symptoms.Key points. A 28-yo female patient was admitted with complains of left ileal pain, abdominal distention and up to 4-day stool delay. The complaints had long been interpreted as clinical manifestations of irritable bowel syndrome. No significant abnormalities were revealed in outpatient check-up (general and biochemical blood panels, stool test, abdominal ultrasound, oesophagogastroduodenoscopy). Colonoscopy was performed on admission, with diagnosis of rectal adenocarcinoma. The patient had a prompt surgical intervention, repeated courses of polychemotherapy and is currently followed by an oncologist and coloproctologist. No relapse signs have been reported.Conclusion. Patients with the complaints satisfying the Rome Criteria Revision IV for functional gastrointestinal diseases should have a thorough examination as per recommendations of the Russian Gastroenterological Association and Russian Association of Coloproctologists.