bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pharmaceutical Reactivation of Attenuated Apoptotic Pathways Leads to Elimination of Osimertinib Drug-Tolerant Cells
Authors: Martin Matthew J. , Floc'h Nicolas , Pfeifer Matthias , Criscione Steven , Delpuech Oona , Gagrica Sladjana , Yao Yi , McDermott Ultan , Smith Paul D. 
Published: September 2022

Osimertinib is an EGFR tyrosine kinase inhibitor (TKI) with proven clinical efficacy; however, acquired resistance presents an obstacle to curing EGFR-driven disease. Recent studies have shown that drug-tolerant persister cells (DTP) have a distinct transcriptional profile that may confer specific vulnerabilities. By definition these cells avoid apoptosis, yet little is known about how their survival is regulated. We found that paradoxically, the proapoptotic gene BIM was upregulated in osimertinib DTPs, and cotreatment with BH3 mimetics could trigger DTP cell death. Furthermore, cIAP proteins, antiapoptotic members of the extrinsic pathway, were significantly elevated in DTPs. cIAP antagonists could block DTP formation as an up-front combination, and could eliminate preformed DTPs. Critically, when treated at the time of maximal osimertinib response, cIAP or MCL1 inhibitor treatment could significantly attenuate the regrowth of EGFRm cell line mouse xenografts. Finally, we show that apoptosis can be maximized in cell lines with acquired osimertinib resistance by combining BH3 or SMAC mimetics with agents that target the resistance driver in these models. Taken together, these data suggest novel therapeutic strategies at the point of minimal residual disease or full osimertinib resistance for patients in this critical area of unmet need.Significance:These studies uncover strategies to use targeted agents that activate apoptosis in non–small cell lung cancer cells that survive initial EGFR TKI treatment.
Arte e cultura popular na academia: possibilidades de diálogo no acervo do Museu D. João VI
Authors: Lima Carolina Rodrigues de 
Published: September 2022

Em 2012, o Museu D. João VI, pertencente à Escola de Belas Artes da Universidade Federal do Rio de Janeiro (UFRJ), recebeu uma coleção de arte popular composta por 1.366 peças de diversas dimensões, materiais e origens. Este artigo pretende refletir sobre o lugar da arte popular em um museu universitário constituído originalmente por coleções acadêmicas compostas por obras de origem europeia ou de tradição ocidental a partir de um breve panorama da trajetória da Coleção Renato Miguez de Arte Popular e os pontos de aproximação entre a constituição desse sistema de representação e os saberes construídos dentro da universidade.
A criação do Sistema de Museus, Acervos e Patrimônio Cultural da UFRJ (Simap): desdobramentos de uma política cultural universitária
Authors: Lima Deborah Rebello , Carvalho Claudia Rodrigues , Garcia Patricia Regina Santos 
Published: September 2022

O artigo apresenta o processo de criação do Sistema de Museus, Acervos e Patrimônio Cultural da Universidade Federal do Rio de Janeiro (Simap-UFRJ), colocando em perspectiva esse modelo de gestão e a vinculação política pela qual é sustentado. A estrutura metodológica se apoia em um breve debate bibliográfico sobre a questão dos museus universitários e da área cultural nas Instituições Federais de Ensino Superior (Ifes), por meio do exemplo da UFRJ. Soma-se a isso um pequeno resgate da história recente do tema na instituição e a tentativa de entender como o Simap vem desenvolvendo suas ações desde seu surgimento. A despeito dos desafios, a atuação do Simap vem ampliando a visibilidade política de museus e espaços científico-culturais dentro da própria universidade, criando condições que permitem concretizar mais mudanças, ainda que a longo prazo, ao incentivar não somente o aporte de recursos, mas, também, novas relações entre esses equipamentos e a estrutura universitária.
Peri–CAR-T practice patterns and survival predictors for all CAR-T patients and post–CAR-T failure in aggressive B-NHL
Authors: Zurko Joanna , Nizamuddin Imran , Epperla Narendranath , David Kevin , Cohen Jonathon B. , Moyo Tamara K. , Ollila Thomas , Hess Brian , Roy Ishan , Ferdman Robert , Liu Jieqi , Chowdhury Sayan Mullick , Romancik Jason , Bhansali Rahul S. , Harris Elyse I. , Sorrell Mckenzie , Masel Rebecca , Kittai Adam S. , Denlinger Nathan , Sigmund Audrey M. , Fitzgerald Lindsey , Galvez Carlos , Ma Shuo , Winter Jane , Pro Barbara , Gordon Leo I. , Danilov Alexey , Stephens Deborah , Shah Nirav N. , Kenkre Vaishalee , Barta Stefan K. , Torka Pallawi , Shouse Geoffrey , Karmali Reem 
Published: September 2022

Abstract
Most patients receiving chimeric antigen receptor T-cell therapy (CAR-T) for aggressive B-cell non-Hodgkin lymphoma (B-NHL) do not experience a durable remission. Several novel agents are approved to treat relapsed, refractory aggressive B-NHL; however, it remains unclear how to sequence these therapies pre– and post–CAR-T. We conducted a multicenter retrospective analysis to describe peri–CAR-T practice patterns and survival predictors for patients receiving CD19-directed CAR-T. Patients (n = 514) from 13 centers treated with CAR-T for B-NHL between 2015-2021 were included in the study. Survival curves were constructed using Kaplan-Meier method. Multivariate Cox regression analysis was used to determine the impact of the variables on survival outcomes. For all patients receiving CAR-T, a greater number of lines of therapy pre-CAR-T apheresis and bridging therapy were predictive of inferior progression-free survival (PFS) and overall survival (OS). The median PFS and OS from the time of CAR-T cell infusion were 7.6 and 25.6 months, respectively. From the time of progression post–CAR-T, the median OS was 5.5 months. The median PFS of treatments administered in the first-line post–CAR-T failure was 2.8 months. Patients with refractory disease on day 30 had inferior OS and were less likely to receive subsequent treatment(s) than other patients with CAR-T failure. Allogeneic hematopoietic cell transplantation for selected patients at any time following CAR-T failure led to durable responses in over half of patients at 1 year. These data provide a benchmark for future clinical trials in patients with post–CAR-T cell progression, which remains an unmet clinical need.
Gray and white matter structural examination for diagnosis of major depressive disorder and subthreshold depression in adolescents and young adults: a preliminary radiomics analysis
Authors: Ma Huan , Zhang Dafu , Sun Dewei , Wang Hongbo , Yang Jianzhong 
Published: September 2022

Abstract
Background
Radiomics is an emerging image analysis framework that provides more details than conventional methods. In present study, we aimed to identify structural radiomics features of gray matter (GM) and white matter (WM), and to develop and validate the classification model for major depressive disorder (MDD) and subthreshold depression (StD) diagnosis using radiomics analysis.

Methods
A consecutive cohort of 142 adolescents and young adults, including 43 cases with MDD, 49 cases with StD and 50 healthy controls (HC), were recruited and underwent the three-dimensional T1 weighted imaging (3D-T1WI) and diffusion tensor imaging (DTI). We extracted radiomics features representing the shape and diffusion properties of GM and WM from all participants. Then, an all-relevant feature selection process embedded in a 10-fold cross-validation framework was used to identify features with significant power for discrimination. Random forest classifiers (RFC) were established and evaluated successively using identified features.

Results
The results showed that a total of 3030 features were extracted after preprocessing, including 2262 shape-related features from each T1-weighted image representing GM morphometry and 768 features from each DTI representing the diffusion properties of WM. 25 features were selected ultimately, including ten features for MDD versus HC, eight features for StD versus HC, and seven features for MDD versus StD. The accuracies and area under curve (AUC) the RFC achieved were 86.75%, 0.93 for distinguishing MDD from HC with significant radiomics features located in the left medial orbitofrontal cortex, right superior and middle temporal regions, right anterior cingulate, left cuneus and hippocampus, 70.51%, 0.69 for discriminating StD from HC within left cuneus, medial orbitofrontal cortex, cerebellar vermis, hippocampus, anterior cingulate and amygdala, right superior and middle temporal regions, and 59.15%, 0.66 for differentiating MDD from StD within left medial orbitofrontal cortex, middle temporal and cuneus, right superior frontal, superior temporal regions and hippocampus, anterior cingulate, respectively.

Conclusion
These findings provide preliminary evidence that radiomics features of brain structure are valid for discriminating MDD and StD subjects from healthy controls. The MRI-based radiomics approach, with further improvement and validation, might be a potential facilitating method to clinical diagnosis of MDD or StD.
Association between cognition and color discrimination among Lebanese patients with schizophrenia
Authors: Dahdouh Oussama , Solh Tala , Lahoud Corinne , Haddad Chadia , Hallit Souheil 
Published: September 2022

Abstract
Background
Patients with schizophrenia (SCZ) exhibit poorer color discrimination than normal individuals. Although retinal abnormalities, as well as cortical and subcortical alterations, found in patients with SCZ have been suggested to cause this poor color discrimination, the impact of cognitive impairment remains to be determined. Dopamine (DA) and glutamate (Glu), known to be disrupted in SCZ, are also suggested to play a role in color discrimination. Our objective was to investigate the contribution of cognitive impairment to color discrimination deficits in SCZ and to examine if these deficits are correlated to SCZ symptoms.

Methods
This study includes 127 patients with SCZ between July and September 2021. The participants completed several questionnaires, specifically the Positive and Negative Syndrome Scale (PANSS), the Montreal Cognitive Assessment (MoCA) test, and the Farnsworth D-15 test, to assess the extent of SCZ symptoms, cognition, and color discrimination respectively.

Results
Higher cognition (Beta = − 0.279) was significantly associated with a lower total error score (TES). Moreover, a higher positive PANSS score (Beta = 0.217) was significantly associated with a higher TES. A multinomial regression analysis taking the type of color blindness as the dependent variable showed that female sex (ORa = 5.46) was significantly associated with a certain type of color blindness.

Conclusion
Color discrimination deficits in patients with SCZ may be due to the effect of cognitive impairment and/or SCZ itself.
The role of Savings and Internal Lending Communities (SILCs) in improving community-level household wealth, financial preparedness for birth, and utilization of reproductive health services in rural Zambia: a secondary analysis
Authors: Lee Ha Eun , Veliz Philip T. , Maffioli Elisa M. , Munro-Kramer Michelle L. , Sakala Isaac , Chiboola Nchimunya M. , Ngoma Thandiwe , Kaiser Jeanette L. , Rockers Peter C. , Scott Nancy A. , Lori Jody R. 
Published: September 2022

Abstract
Background
Savings and Internal Lending Communities (SILCs) are a type of informal microfinance mechanism widely adapted in Zambia. The benefits of SILCs paired with other interventions have been studied in many countries. However, limited studies have examined SILCs in the context of maternal health. This study examined the association between having access to SILCs and: 1) household wealth, 2) financial preparedness for birth, and 3) utilization of various reproductive health services (RHSs).

Methods
Secondary analysis was conducted on baseline and endline household survey data collected as part of a Maternity Waiting Home (MWH) intervention trial in 20 rural communities across seven districts of Zambia. Data from 4711 women who gave birth in the previous year (baseline: 2381 endline: 2330) were analyzed. The data were stratified into three community groups (CGs): CG1) communities with neither MWH nor SILC, CG2) communities with only MWH, and CG3) communities with both MWH and SILC. To capture the community level changes with the exposure to SILCs, different women were randomly selected from each of the communities for baseline and endline data, rather than same women being surveyed two times. Interaction effect of CG and timepoint on the outcome variables – household wealth, saving for birth, antenatal care visits, postnatal care visits, MWH utilization, health facility based delivery, and skilled provider assisted delivery – were examined.

Results
Interaction effect of CGs and timepoint were significantly associated only with MWH utilization, health facility delivery, and skilled provider delivery. Compared to women from CG3, women from CG1 had lower odds of utilizing MWHs and delivering at health facility at endline. Additionally, women from CG1 and women from CG2 had lower odds of delivering with a skilled provider compared to women from CG3.

Conclusion
Access to SILCs was associated with increased MWH use and health facility delivery when MWHs were available. Furthermore, access to SILCs was associated with increased skilled provider delivery regardless of the availability of MWH. Future studies should explore the roles of SILCs in improving the continuity of reproductive health services.

Trial registration
NCT02620436.
Comparison of obesity-related indicators for identifying metabolic syndrome among normal-weight adults in rural Xinjiang, China
Authors: Jian Le-yao , Guo Shu-xia , Ma Ru-lin , He Jia , Rui Dong-sheng , Ding Yu-song , Li Yu , Sun Xue-ying , Mao Yi-dan , He Xin , Liao Sheng-yu , Guo Heng 
Published: September 2022

Abstract
Background
This study aimed to compare the ability of certain obesity-related indicators to identify metabolic syndrome (MetS) among normal-weight adults in rural Xinjiang.

Methods
A total of 4315 subjects were recruited in rural Xinjiang. The questionnaire, biochemical and anthropometric data were collected from them. Binary logistic regression was used to analyze the association between the z-score of each index and MetS. The area under the receiver-operating characteristic (ROC) curves were used to compare the diagnostic ability of each index. According to the cut-off value of each index, nomogram models were established and their diagnostic ability were evaluated.

Results
After adjusting for confounding factors, each indicator in different genders was correlated with MetS. Triglyceride-glucose index (TyG index) showed the strongest association with MetS in both males (OR = 3.749, 95%CI: 3.173–4.429) and females (OR = 3.521,95%CI: 2.990–4.148). Lipid accumulation product (LAP) showed the strongest diagnostic ability in both males (AUC = 0.831, 95%CI: 0.806–0.856) and females (AUC = 0.842, 95%CI: 0.820–0.864), and its optimal cut-off values were 39.700 and 35.065, respectively. The identification ability of the TyG index in different genders (males AUC: 0.817, females AUC: 0.817) was slightly weaker than LAP. Waist-to-height ratio (WHtR) had the similar AUC (males: 0.717, females: 0.747) to conicity index (CI) (males: 0.734, females: 0.749), whereas the identification ability of a body shape index (ABSI) (males AUC: 0.700, females AUC: 0.717) was relatively weak. Compared with the diagnostic ability of a single indicator, the AUC of the male nomogram model was 0.876 (95%CI: 0.856–0.895) and the AUC of the female model was 0.877 (95%CI: 0.856–0.896). The identification ability had been significantly improved.

Conclusion
LAP and TyG index are effective indicators for identifying MetS among normal-weight adults in rural Xinjiang. Nomogram models including age, CI, LAP, and TyG index can significantly improve diagnostic ability.
Evaluating the influence of financial investment in compulsory education on the health of Chinese adolescents: a novel approach
Authors: Yang Kewen , Fahad Shah , Yuan Feimin 
Published: September 2022

Abstract
Background
With China's aging and declining fertility rate, the importance of population quality is increasing. As the main force of the labor market in the future, the Chinese government tries to promote the development of adolescents by increasing the financial investment in compulsory education, so as to improve the future population quality of China and enhance the national competitiveness. Therefore, the aim of this study was to investigate the relationship between financial investment in compulsory education and the health of Chinese adolescents.

Methods
This study specifically uses data obtained from China Education Panel Survey (CEPS). The data were nationally representative, which covered families, schools, and communities. For the CEPS data obtained, the 2013–2014 school year was the baseline, and two cohorts of 7th and 9th graders were the starting point of the survey. In the 2014–2015 school year, 8th-grade students who participated in the baseline survey (7th-grade students in the 2013–2014 school year) were followed up. Since the second period only began to investigate the data on financial investment in compulsory education, this article uses the data from the 2014–2015 academic year for research. OLS and Ordered Probit models were used to investigate the impact of financial investment in compulsory education on adolescent health.

Results
With the doubling of financial investment in compulsory education, self-rated health increased by 0.021, frequency of illness decreased by 0.03, the number of sick leave days decreased by 0.207, and depression decreased by 0.191. The heterogeneity analysis shows that compared to only-child, high-income and nonagricultural groups, the financial investment in compulsory education has a greater impact on the health of adolescents with the characteristics of agriculture hukou, non-only-child and low-income families. Further analysis of the impact mechanism shows that financial investment in compulsory education exerts a significant influence on the health of adolescents by easing family budget constraints, improving school sports facilities, and increasing the expected return of health investment and social capital.

Conclusions
Financial investment in compulsory education can enhance the health of adolescents, and vulnerable groups benefit more, which is conducive to promoting health equity.
Zero knowledge and high interest in the use of long-acting injectable pre-exposure prophylaxis (PrEP) among adolescent men who have sex with men and transgender women in two capital cities in Brazil
Authors: Pedrana Leo , Magno Laio , Zucchi Eliana Miura , da Silva Luís Augusto Vasconcelos , Ferraz Dulce , Grangeiro Alexandre , Castellanos Marcelo , Brasil Sandra Assis , Dourado Inês 
Published: September 2022

AbstractBackgroundAdolescent men who have sex with men (aMSM) and transgender women (aTGW) are affected disproportionately by human immunodeficiency virus (HIV) infection. Although new methods of pre-exposure prophylaxis (PrEP), such as long-acting injectable (LAI-PrEP), have been approved by the Food and Drug Administration, their acceptability among aMSM/aTGW is not well known.MethodsForty-eight semi-structured interviews were conducted to assess the knowledge and interest in LAI-PrEP among aMSM/aTGW enrolled in a daily oral PrEP cohort from two capital cities of Brazil since 2019.ResultsPrevious knowledge of LAI-PrEP remains scarce, but the high interest regarding its use has been reported. Interest in the use of LAI-PrEP is associated with eliminating the burden of daily responsibility or the risk of missing the necessary medications, lowering the costs of this method, increasing confidentiality, and decreasing the frequency of visiting PrEP clinics. The reported barriers to uptake included fear of injection, doubts on its effectiveness, side effects, and greater dependence on a health provider.ConclusionsThere is an urgent need to strengthen the preventive strategies against HIV infection among the youth, enhance their knowledge and those of healthcare providers, and offer safe and new options.
Treatment of inferior pole fracture of the patella with tension-free external immobilization
Authors: Pu Shaoquan , Chen Yanling , Liang Jinlong , Xu Yongqing , Zhao Yonghui 
Published: September 2022

Abstract
Background
Inferior pole fracture of the patella (IPFP) has small and comminuted fracture blocks that are hard to immobilize, and early mobilization may lead to loss of fracture reduction and immobilization failure. Therefore, a difficulty of treatment is to achieve rigid immobilization with early functional exercise. Here, a new treatment method of tension-free external immobilization is put forward.

Methods
The clinical data of 11 IPFP patients treated with tension-free external immobilization from May 2016 to June 2019 were retrospectively analyzed. There were six males and five females aged 39.0 ± 12.8 years (range 18–53 years). IPFP was caused by traffic accidents in five cases and falls in six cases. All cases had unilateral closed injuries, including four in the left knee and seven in the right knee. The preoperative range of motion of the knee was 22.0 ± 7.5° (10–30°). The time from injury to operation was 4.5 ± 1.3 d (3–7 d). The operation-related indices were recorded, and the function of the affected knee was assessed by the Böstman score.

Results
All operations were successful. The operation time was 56.4 ± 8.4 mi (45–70 min), the intraoperative blood loss was 54.1 ± 14.6 mL (40–80 mL), and the length of hospital stay was 7.5 ± 1.9 d (5–11 d). The mean follow-up time was 20.4 ± 7.6 months (12–36 months), the duration of fracture healing was 8.9 ± 1.5 weeks (7–12 weeks), and the removal time of the external immobilization device was 10.4 ± 0.9 weeks (9–12 weeks). At the last follow-up, the range of motion had no significant difference between the affected knee (129.7 ± 3.3°, range 125–135°) and the unaffected knee (130.8 ± 3.8°, range 126–137°) (t = 0.718, p < 0.05). The Böstman score of the knee was 29.2 ± 1.0 points (27–30 points), including 10 excellent cases (90.9%) and one good case (9.1%).

Conclusion
Tension-free external immobilization is a feasible treatment for IPFP. It can help with early functional exercise and achieve a satisfactory clinical effect.