bluuebunny/crossref_metadata_2025_split huggingface dataset:
Building a launchpad for satellite cyber-security research: lessons from 60 years of spaceflight
Authors: Pavur James , Martinovic Ivan 
Published: June 2022

AbstractAs the space industry approaches a period of rapid change, securing both emerging and legacy satellite missions will become vital. However, space technology has been largely overlooked by the systems security community. This survey seeks to understand why this is the case and to offer a starting point for technical security researchers seeking impactful contributions beyond the Earth’s mesosphere. The paper begins with a cross-disciplinary synthesis of relevant threat models from a diverse array of fields, ranging from legal and policy studies to aerospace engineering. This is presented as a “threat matrix toolbox,” which security researchers may leverage to motivate technical research into given attack vectors and defenses. We derive this model from an original chronology of &gt; 100 significant satellite hacking incidents spanning the previous 60 years. Together, these are used to assess the state-of-the-art in satellite security across four sub-domains: satellite radio-link security, space hardware security, ground station security, and operational/mission security. In each area, we note significant findings and unresolved questions which the systems security community is aptly poised to tackle. By consolidating this research, we present the case that satellite systems security researchers can build on strong, but disparate, academic foundations and rise to meet an urgent need for future space missions.
Clozapine Treatment Is Associated With Higher Prescription Rate of Antipsychotic Monotherapy and Lower Prescription Rate of Other Concomitant Psychotropics: A Real-World Nationwide Study
Authors: Ochi Shinichiro , Tagata Hiromi , Hasegawa Naomi , Yasui-Furukori Norio , Iga Jun-ichi , Kashiwagi Hiroko , Kodaka Fumitoshi , Komatsu Hiroshi , Tsuboi Takashi , Tokutani Akira , Numata Shusuke , Ichihashi Kayo , Onitsuka Toshiaki , Muraoka Hiroyuki , Iida Hitoshi , Ohi Kazutaka , Atake Kiyokazu , Kishimoto Taishiro , Hori Hikaru , Takaesu Yoshikazu , Takeshima Masahiro , Usami Masahide , Makinodan Manabu , Hashimoto Naoki , Fujimoto Michiko , Furihata Ryuji , Nagasawa Tatsuya , Yamada Hisashi , Matsumoto Junya , Miura Kenichiro , Kido Mikio , Hishimoto Akitoyo , Ueno Shu-ichi , Watanabe Koichiro , Inada Ken , Hashimoto Ryota 
Published: June 2022

Abstract

Background
Although clozapine is effective for treatment-resistant schizophrenia (TRS), the rate of clozapine prescription is still low. Whereas antipsychotic monotherapy is recommended in clinical practice guidelines, the rate of antipsychotic polypharmacy is still high. There is little evidence on whether a clozapine prescription influences changes in the rate of monotherapy and polypharmacy, including antipsychotics and other psychotropics. We therefore hypothesized that the rate of antipsychotic monotherapy in patients with TRS who were prescribed clozapine would be higher than that in patients with schizophrenia who were not prescribed clozapine.

Methods
We assessed 8306 patients with schizophrenia nationwide from 178 institutions in Japan from 2016 to 2019. We analyzed the psychotropic prescription data at discharge in patients diagnosed with TRS and with no description of TRS (ND-TRS) based on the diagnosis listed in the discharge summary.

Results
The rate of antipsychotic monotherapy in the TRS with clozapine group (91.3%) was significantly higher than that in the TRS without clozapine group (45.9%; P &lt; 2.0 × 10−16) and the ND-TRS without clozapine group (54.7%; P &lt; 2.0 × 10−16). The rate of antipsychotic monotherapy without any other concomitant psychotropics in the TRS with clozapine group (26.5%) was significantly higher than that in the TRS without clozapine group (12.6%; P = 1.1 × 10−6) and the ND-TRS without clozapine group (17.0%; P = 5.9 × 10−6).

Conclusions
Clozapine prescription could be associated with a high rate of antipsychotic monotherapy. Patients will benefit from the correct diagnosis of TRS and thus from proper clozapine prescription.
Role of interferons (IFNs) in the differentiation of T peripheral helper (Tph) cells
Authors: Tanemura Shuhei , Tsujimoto Hideto , Seki Noriyasu , Kojima Shinji , Miyoshi Fumihiko , Sugahara Kunio , Yoshimoto Keiko , Suzuki Katsuya , Kaneko Yuko , Chiba Kenji , Takeuchi Tsutomu 
Published: June 2022

Abstract
T follicular helper (Tfh) cells and T peripheral helper (Tph) cells produce interleukin (IL)-21 and are thought to contribute to follicular and extra-follicular B-cell activation, respectively, in autoimmune diseases. It is known that programmed cell death-1 (PD-1)-positive CXCR5+ Tfh-like cells are differentiated from human naive CD4+ T cells by IL-12 plus transforming growth factor (TGF)-β. However, it remains unclear what cytokines are required for Tph differentiation. In this study, we found that interferon (IFN)-α and IFN-β reduce the frequency of Tfh-like cells under the IL-12 plus TGF-β condition, whereas they promote generation of PD-1+CXCR5−CD4+ T cells and secretion of IL-21, IFN-γ and CXCL13. Intracellular cytokine staining and T-cell–B-cell co-culture studies indicated that IFN-α promotes generation of IL-21+IFN-γ +CXCR5−CD4+ T cells thereby enhancing B-cell helper function. By IFN-α treatment, the mRNA levels of IL21, IFNG, CXCL13, CD244, SLAMF7, GZMB and PRDM1 were significantly up-regulated but BCL6 mRNA expression was down-regulated, suggesting a Tph-related gene expression pattern. On the other hand, IL-2-neutralization increased mRNA levels of IL21, CXCL13 and CXCR5, retained BCL6, but showed no clear effect on IFNG or PRDM1. RNA sequencing analyses revealed that PD-1hiCXCR5−CD4+ T cells prepared from in vitro culture show a Tph-related gene expression pattern similar with that of PD-1hiCXCR5− Tph cells obtained from the blood of patients with systemic lupus erythematosus. From our findings, it is highly probable that type I IFNs play a key role in differentiation of Tph cells and trigger Tph cell expansion in autoimmune diseases.
Validation and Prioritization of Design Options for Accessible Player Experiences
Authors: Power Christopher , Cairns Paul , Barlet Mark , Haynes Gregory , Beeston Jen , DeHaven Triskal 
Published: June 2022

Abstract
The profile of accessible design of digital games has increased rapidly in both research and practice. Whereas at one time accessibility was a niche area of interest, it is now a key feature promoted in commercial gaming. Typically, games achieve accessibility by offering a range of options, both in settings and gameplay, that players can customize to meet their individual needs and preferences. However, there is a distinct lack of systematic data regarding the accessibility options that players prefer, how options can be prioritized in design or how options can impact player experience. This paper presents a study that collects data about options preferred by players and uses it to expand and validate a design vocabulary for accessible design in games. Further, the results point to a need to prioritize particular types of options, specifically those relating to the player-feedback loop of games, before implementing options that modify the challenges encountered by players.
Economic evaluation of antimicrobial stewardship in primary care: a systematic review and quality assessment
Authors: Wubishet Befikadu L , Merlo Gregory , Ghahreman-Falconer Nazanin , Hall Lisa , Comans Tracy 
Published: June 2022

Abstract

Background
Primary care accounts for 80%–90% of antimicrobial prescriptions, making this setting an important focus for antimicrobial stewardship (AMS) interventions.

Objectives
To collate the findings and critically appraise the qualities of economic evaluation studies of AMS or related interventions aimed at reducing inappropriate antimicrobial prescribing in primary care.

Methods
A systematic review of economic evaluations of interventions aimed at reducing inappropriate antimicrobial prescribing in primary care was performed. Published literature were retrieved through a search of Medline, Embase, EconLit and Web of Science databases for the period 2010 to 2020. The quality of the studies was assessed using the Consensus on Health Economic Criteria checklist and Good Practice Guidelines for Decision-Analytic Modelling in Health Technology Assessment.

Results
Of the 2722 records identified, 12 studies were included in the review (8 trial-based and 4 modelled evaluations). The most common AMS interventions were communication skills training for health professionals and C-reactive protein point-of-care testing (CRP-POCT). Types of economic evaluations included in the review were cost-effectiveness (7 studies), cost-utility (1), cost-benefit (2), cost-effectiveness and cost-utility (1) and cost analysis (1). While six of the studies found AMS interventions to be cost-effective, the other six reported them as not cost-effective or inconclusive. The quality of the studies ranged from good to low.

Conclusions
There were significant variations in cost-effectiveness of AMS interventions across studies and depending on the inclusion of cost components such as the cost of antimicrobial resistance. However, communication skills training and CRP-POCT were frequently cost-effective or cost-beneficial for reducing inappropriate antimicrobial prescribing.
Automated Library Construction and Analysis for High-Throughput Nanopore Sequencing of SARS-CoV-2
Authors: Coope Robin J N , Matic Nancy , Pandoh Pawan K , Corbett Richard D , Smailus Duane E , Pleasance Stephen , Lowe Christopher F , Ritchie Gordon , Chorlton Samuel D , Young Matthew , Ally Adrian A , Asano Jennifer K , Carlsen Rebecca E , Chahal Sundeep S , Zhao Yongjun , Holmes Daniel T , Romney Marc G , Jones Steven J M , Marra Marco A 
Published: June 2022

AbstractBackgroundTo support the implementation of high-throughput pipelines suitable for SARS-CoV-2 sequencing and analysis in a clinical laboratory, we developed an automated sample preparation and analysis workflow.MethodsWe used the established ARTIC protocol with approximately 400 bp amplicons sequenced on Oxford Nanopore’s MinION. Sequences were analyzed using Nextclade, assigning both a clade and quality score to each sample.ResultsA total of 2179 samples on twenty-five 96-well plates were sequenced. Plates of purified RNA were processed within 12 h, sequencing required up to 24 h, and analysis of each pooled plate required 1 h. The use of samples with known threshold cycle (Ct) values enabled normalization, acted as a quality control check, and revealed a strong correlation between sample Ct values and successful analysis, with 85% of samples with Ct &lt; 30 achieving a “good” Nextclade score. Less abundant samples responded to enrichment with the fraction of Ct &gt; 30 samples achieving a “good” classification rising by 60% after addition of a post-ARTIC PCR normalization. Serial dilutions of 3 variant of concern samples, diluted from approximately Ct = 16 to approximately Ct = 50, demonstrated successful sequencing to Ct = 37. The sample set contained a median of 24 mutations per sample and a total of 1281 unique mutations with reduced sequence read coverage noted in some regions of some samples. A total of 10 separate strains were observed in the sample set, including 3 variants of concern prevalent in British Columbia in the spring of 2021.ConclusionsWe demonstrated a robust automated sequencing pipeline that takes advantage of input Ct values to improve reliability.
Extending lactation length: consequences for cow, calf, and farmer
Authors: van Knegsel Ariette T M , Burgers Eline E A , Ma Junnan , Goselink Roselinde M A , Kok Akke 
Published: June 2022

Abstract
Traditionally, a 1-yr calving interval is advised to farmers from an economical point of view, to realize a yearly peak in milk yield. A 1-yr calving interval, however, implies a yearly event of drying-off, calving and start of lactation, which are all associated with an increased risk for diseases and disorders. Deliberately extending the lactation length by extending the voluntary waiting period (VWP) for first insemination reduces the frequency of these challenging events. This reduction in frequency of calvings can be beneficial for cow health and fertility, but also can be of interest to reduce the number of surplus calves and labor associated with drying off, calving, and disease treatments. Current concerns with respect to an extended lactation are that milk yield is too low in late lactation, which might be associated with an increased risk of fattening of cows in late lactation, and compromised economic returns at herd level. In addition, limited knowledge is available with respect to consequences for cow performance in the subsequent lactation and for calves born to cows with an extended lactation. Moreover, response of dairy cows to an extended VWP depends on individual cow characteristics like parity, milk yield level or body condition. A customized strategy based on individual cow characteristics can be a future approach to select high-producing cows with persistent lactation curves for an extended lactation to limit the risk for fattening and milk yield reduction at the end of the lactation while benefitting from a reduction in challenging events around calving.
Revision Surgery Following Severe Frostbite Injury Compared to Similar Hand and Foot Burns
Authors: Coward Alexandra , Endorf Frederick W , Nygaard Rachel M 
Published: June 2022

Abstract
Severe frostbite is associated with loss of digits or limbs and high levels of morbidity. The current practice is to salvage as much of the limb/digit as possible with the use of thrombolytic and adjuvant therapies. Sequelae from amputation can include severe nerve pain and poor wound healing requiring revision surgery. The aim of this study was to examine the rate of revision surgery after primary amputation and compare this to revision surgery in isolated hand/foot burns. Frostbite and burn patients from 2014 to 2019 were identified in the prospectively maintained database at a single urban burn and trauma center. Patients with primary amputations related to isolated hand/foot burns or frostbite were included in the study. Descriptive statistics included Student’s t-test and Fisher’s exact test. A total of 63 patients, 54 frostbite injuries and 9 isolated hand or foot burns, met inclusion criteria for the study. The rate of revision surgery was similar following frostbite and burn injury (24% vs 33%, P = .681). There were no significant differences in age, sex, or length of stay on the primary hospitalization between those that required revision surgery and those that did not. Neither the impacted limb nor the presence of infection or cellulitis on primary amputation was associated with future need for revision surgery. Of the 16 patients requiring revision surgery, 5 (31%) required additional debridement alone, 6 (38%) required reamputation alone, and 5 required both. A total of 6 patients (38%) had cellulitis or infection at the time of revision surgery. Time from primary surgery to revision ranged from 4 days to 3 years. Planned, delayed primary amputation is a mainstay of frostbite management. To our knowledge, this is the first assessment of revision surgery in the setting of severe frostbite injury. Our observed rate of revision surgery following frostbite injury did not differ significantly from revision surgery in the setting of isolated hand or foot burns. This study brings up important questions of timing and surgical planning in these complex patients that will require a multicenter collaborative study.
Chemotherapy Regimens Received by Women With BRCA1/2 Pathogenic Variants for Early Stage Breast Cancer Treatment
Authors: Kurian Allison W , Abrahamse Paul , Hamilton Ann S , Caswell-Jin Jennifer L , Gomez Scarlett L , Hofer Timothy J , Ward Kevin C , Katz Steven J 
Published: June 2022

Abstract

Background
Genetic testing is widespread among breast cancer patients; however, no guideline recommends using germline genetic testing results to select a chemotherapy regimen. It is unknown whether breast cancer patients who carry pathogenic variants (PVs) in BRCA1 and/or 2 (BRCA1/2) or other cancer-associated genes receive different chemotherapy regimens than noncarriers.

Methods
We linked Surveillance, Epidemiology, and End Results registry records from Georgia and California to germline genetic testing results from 4 clinical laboratories. Patients who 1) had stages I-III breast cancer, either hormone receptor (HR) positive and HER2 negative or triple negative (TNBC), diagnosed in 2013-2017; 2) received chemotherapy; and 3) were linked to genetic results were included. Chemotherapy details were extracted from Surveillance, Epidemiology, and End Results text fields completed by registrars. We examined whether PV carriers received more intensive regimens (HR-positive,HER2-negative: ≥3 drugs including an anthracycline; TNBC: ≥4 drugs including an anthracycline and platinum) and/or less standard breast cancer agents (a platinum). All statistical tests were 2-sided.

Results
Among 2293 patients, 1451 had HR-positive, HER2-negative disease, and 842 had TNBC. On multivariable analysis of women with HR-positive, HER2-negative disease, receipt of a more intensive chemotherapy regimen varied statistically significantly by genetic results (P = .02), with platinum receipt more common among BRCA1/2 PV carriers (odds ratio = 2.44, 95% confidence interval = 1.36 to 4.38; P &lt; .001). Among women with TNBC, chemotherapy agents did not vary significantly by genetic results.

Conclusion
BRCA1/2 PV carriers with HR-positive, HER2-negative breast cancer had twofold higher odds than noncarriers of receiving a platinum, as part of a more intensive chemotherapy regimen. This likely represents overtreatment and emphasizes the need to monitor how genetic testing results are managed in oncology practice.
Botany, traditional uses, phytochemistry, pharmacological and toxicological effects of Croton tiglium Linn.: a comprehensive review
Authors: Zhang Ting , Liu Zibo , Sun Xue , Liu Ziqi , Zhang Lilin , Zhang Qing , Peng Wei , Wu Chunjie 
Published: June 2022

Abstract

Objectives
Croton tiglium Linn. (Euphorbiaceae) is an ancient medicinal plant that has been used for a long time, which is widely distributed in tropical and subtropical regions. And it is widely used for defecation, induced labour, treatment of gastrointestinal diseases, headache, as well as rheumatoid arthritis.

Key findings
Approximately 150 compounds have been isolated and identified from the seeds, stems, leaves and branches of C. tiglium, including fatty acids, terpenoids, alkaloids, the plants proteins and other types of components. Based on a wide range of biological properties, C. tiglium has a wide range of pharmacological effects, such as antitumor, anti-HIV, analgesic, anti-inflammatory and antibacterial effects.

Summary
The review aims to provide a critical and comprehensive evaluation of the botany, phytochemistry, pharmacology and toxicity of C. tiglium, with a vision for promoting further pharmaceutical research to explore its complete potential for better clinical application. The tigliane diterpenoids have been the most studied compounds isolated from C. tiglium, which showing a variety of biological activities, but there is insufficient evidence to explain the mechanism of action. In addition, C. tiglium may have potential toxic effects, and it is necessary to reduce the toxic effects to ensure the safety of clinical medication, which may promote the discovery and development of new drugs.
Empirically motivated early feedback: momentum input by stellar feedback in galaxy simulations inferred through observations
Authors: Keller Benjamin W , Kruijssen J M Diederik , Chevance Mélanie 
Published: June 2022

ABSTRACT
We present a novel method for including the effects of early (pre-supernova) feedback in simulations of galaxy evolution. Rather than building a model which attempts to match idealized, small-scale simulations or analytic approximations, we rely on direct observational measurements of the time-scales over which star-forming molecular clouds are disrupted by early feedback. We combine observations of the spatial de-correlation between molecular gas and star formation tracers on ∼100 pc scales with an analytic framework for the expansion of feedback fronts driven by arbitrary sources or mechanisms, and use these to constrain the time-scale and momentum injection rate by early feedback. This allows us to directly inform our model for feedback from these observations, sidestepping the complexity of multiple feedback mechanisms and their interaction below the resolution scale. We demonstrate that this new model has significant effects on the spatial clustering of star formation, the structure of the ISM, and the driving of outflows from the galactic plane, while preserving the overall regulation of the galaxy-integrated star formation rate. We find that this new feedback model results in galaxies that regulate star formation through the rapid disruption of star-forming clouds, rather than by highly efficient, global galactic outflows. We also demonstrate that these results are robust to stochasticity, degraded numerical resolution, changes in the star formation model parameters, and variations in the single free model parameter that is unconstrained by observations.
The Sloan Digital Sky Survey peculiar velocity catalogue
Authors: Howlett Cullan , Said Khaled , Lucey John R , Colless Matthew , Qin Fei , Lai Yan , Tully R Brent , Davis Tamara M 
Published: June 2022

ABSTRACT
We present a new catalogue of distances and peculiar velocities (PVs) of 34 059 early-type galaxies derived from fundamental plane (FP) measurements using data from the Sloan Digital Sky Survey (SDSS). This $7016\, \mathrm{deg}^{2}$ homogeneous sample comprises the largest set of PVs produced to date and extends the reach of PV surveys up to a redshift limit of z = 0.1. Our SDSS-based FP distance measurements have a mean uncertainty of 23 per cent. Alongside the data, we produce an ensemble of 2048 mock galaxy catalogues that reproduce the data selection function, and are used to validate our fitting pipelines and check for systematic errors. We uncover a significant trend between group richness and mean surface brightness within the sample, which may hint at an environmental dependence within the FP or the presence of unresolved systematics, and can result in biased PVs. This is removed by using multiple FP fits as function of group richness, a procedure made tractable through a new analytic derivation for the integral of a three-dimensional (3D) Gaussian over non-trivial limits. Our catalogue is calibrated to the zero-point of the CosmicFlows-III sample with an uncertainty of 0.004 dex (not including cosmic variance or the error within CosmicFlows-III itself), which is validated using independent cross-checks with the predicted zero-point from the 2M++ reconstruction of our local velocity field. Finally, as an example of what is possible with our new catalogue, we obtain preliminary bulk flow measurements up to a depth of $135\,{\rm h}^{-1}\mathrm{Mpc}$. We find a slightly larger-than-expected bulk flow at high redshift, although this could be caused by the presence of the Shapley supercluster, which lies outside the SDSS PV footprint.