bluuebunny/crossref_metadata_2025_split huggingface dataset:
Socioeconomic Status and Medication Use in Rheumatoid Arthritis: A Scoping Review
Authors: Russell Oscar , Lester Susan , Black Rachel J. , Hill Catherine L. 
Published: September 2022

ObjectiveSocioeconomic status (SES) influences disease outcomes in rheumatoid arthritis (RA) patients. Differences in medication use may partly explain this association. A scoping review was used to identify research conducted on this topic and determine what knowledge gaps remain.MethodsMedline, Embase, and PsychInfo were searched from their inception until February 2022 for studies that assessed SES and medication use as an outcome variable. Data was extracted on the use of specific SES measures, medication use, and whether differences in SES variables were associated with differences in medication use.ResultsWe identified 2,103 studies, of which 81 were selected for inclusion. Included studies originated most frequently from the US (42%); the mean ± SD age of participants was 55.9 ± 6.8 years, and most were female (75%). Studies measured a median of 4 SES variables (interquartile range 3–6), with educational, area‐level SES, and income being the most frequent measurements used. Patients' race and/or ethnicity were documented by 34 studies. Studies primarily assessed the likelihood of prescription of disease‐modifying antirheumatic drugs or dispensation, medication adherence, or treatment delays. A majority of studies documented at least 1 SES measure associated with a difference in medication use.ConclusionThere is some evidence that SES affects use of medications in patients with RA; however, multiple definitions of SES have been utilized, making comparisons between studies difficult. Prospective studies with consistently defined SES will be needed to determine whether differences in medication use accounts for the poorer outcomes experienced by patients of lower SES.
Multiphase Morphology with Enhanced Carrier Lifetime via Quaternary Strategy Enables High‐Efficiency, Thick‐Film, and Large‐Area Organic Photovoltaics
Authors: Zhan Lingling , Yin Shouchun , Li Yaokai , Li Shuixing , Chen Tianyi , Sun Rui , Min Jie , Zhou Guanqing , Zhu Haiming , Chen Yiyao , Fang Jin , Ma Chang‐Qi , Xia Xinxin , Lu Xinhui , Qiu Huayu , Fu Weifei , Chen Hongzheng 
Published: September 2022

AbstractWith the continuous breakthrough of the efficiency of organic photovoltaics (OPVs), their practical applications are on the agenda. However, the thickness tolerance and upscaling in recently reported high‐efficiency devices remains challenging. In this work, the multiphase morphology and desired carrier behaviors are realized by utilizing a quaternary strategy. Notably, the exciton separation, carrier mobility, and carrier lifetime are enhanced significantly, the carrier recombination and the energy loss (Eloss) are reduced, thus beneficial for a higher short‐circuit density (JSC), fill factor (FF), and open‐circuit voltage (VOC) of the quaternary system. Moreover, the intermixing‐phase size is optimized, which is favorable for constructing the thick‐film and large‐area devices. Finally, the device with a 110 nm‐thick active layer shows an outstanding power conversion efficiency (PCE) of 19.32% (certified 19.35%). Furthermore, the large‐area (1.05 and 72.25 cm2) devices with 110 nm thickness present PCEs of 18.25% and 12.20%, and the device with a 305 nm‐thick film (0.0473 cm2) delivers a PCE of 17.55%, which are among the highest values reported. The work demonstrates the potential of the quaternary strategy for large‐area and thick‐film OPVs and promotes the practical application of OPVs in the future.
Recent Advances in Silver Nanowire Based Flexible Capacitive Pressure Sensors: From Structure, Fabrication to Emerging Applications
Authors: Basarir Fevzihan , Madani Zahra , Vapaavuori Jaana 
Published: September 2022

AbstractSkin mountable flexible pressure sensors are crucial for the next generation technologies. Capacitive pressure sensors bring several advantages and hence, they have been preferred over piezoelectric and piezoresistive alternatives. Flexible electrode and dielectric material are the fundamental components of the capacitive flexible pressure sensors. Hence, solution processable silver nanowires (AgNWs) are highly promising as electrode material or filler material in dielectric layer, owing to their superior inherent conductivity and flexibility. This article reviews recent progress on fabrication of flexible capacitive pressure sensors with AgNWs used as electrode and dielectric material. Performance of the sensors based on AgNWs is comprehensively discussed and emerging applications, as well as future outlook, are presented in detail.
Self‐Templated Synthesis of CoFeP @ C Cage‐In‐Cage Superlattices for Enhanced Electrocatalytic Water Splitting
Authors: Deng Yuwei , Cao Yangfei , Xia Yan , Xi Xiangyun , Wang Yun , Jiang Wenfeng , Yang Dong , Dong Angang , Li Tongtao 
Published: September 2022

AbstractDesigning highly‐efficient, cost‐effective, and stable electrocatalysts for water splitting is of great significance for implementing renewable energy technologies. Herein, a self‐templated strategy is employed to fabricate 2D porous electrocatalysts of heterometallic phosphides featuring a cage‐in‐cage superlattice architecture. The as‐made heterometallic phosphide electrocatalysts, comprising a layer of close‐packed CoFeP nanocages intimately embedded in an interconnected carbon‐cage framework, are converted from carbon‐coated CoFeO nanocrystal superlattices by one‐step phosphidation. Benefiting from the unique hierarchical porous structure and the ability of modulating the Co/Fe molar ratio, such 2D CoFeP @ C cage‐in‐cage superlattices show remarkable activity and stability for both oxygen evolution reaction (OER) and hydrogen evolution reaction (HER) in alkaline media. Moreover, water electrolyzers constructed using CoFeP @ C superlattices as both cathode and anode require a low cell voltage of 1.55 V to achieve a current density of 10 mA cm−2, outperforming most nonprecious metal‐based electrocatalysts reported previously. The superior electrocatalytic performance of CoFeP @ C superlattices is revealed by density functional theory calculations. These findings provide new opportunities for developing efficient and stable bifunctional electrocatalysts for water splitting.
One‐year outcomes of laparoscopic sleeve gastrectomy in morbidly obese patients regarding the age, gender, and postoperative follow‐ups
Authors: Tabasi Mohsen , Farsimadan Marziye , Yazdannasab Mohammadreza , Elyasinia Fezzeh , Siadat Seyed Davar , Soroush Ahmadreza 
Published: September 2022

AbstractThe outcome of laparoscopic sleeve gastrectomy (LSG), one of the most common bariatric surgery (BS) procedure, may differ depending on the patient's age, gender, and postoperative follow‐ups. In this study, we aimed to evaluate the efficacy of LSG technique on weight loss, obesity‐associated co‐morbidities and complications in patients undergoing LSG over 3 months and 1 year, regarding their age, gender, and postoperative follow‐ups. The LSG associated complications in participants regarding their preoperative BMI (<39.9 and >39.9), age (30‐40 and 40‐50), and gender were assessed after 3 and 12 months. Besides, the remission and improvement rates of comorbid conditions in patients were examined after 12 months of LSG. Our results showed that LSG led to a significant weight loss in the resolution of obesity‐associated co‐morbidities and different complications after 1 year. No significant difference was found in the improvement and the resolution of obesity‐associated co‐morbidities according to gender. Also, the class 3 patients had significantly higher rates of hearing loss after 12 months and had higher levels of depression and brittle nails 3 months after the surgery. The younger patients also showed a significantly higher percentage of dry skin, intolerance to bread, and menstrual disorder compared to the older group. In conclusion, this study emphasized the importance and necessity of further research into the factors influencing the outcome of LSG such as age, gender, and postoperative follow‐ups.
Menopause hormone therapy significantly alters pathophysiological biomarkers of Alzheimer's disease
Authors: Depypere Herman , Vergallo Andrea , Lemercier Pablo , Lista Simone , Benedet Andrea , Ashton Nicholas , Cavedo Enrica , Zetterberg Henrik , Blennow Kaj , Vanmechelen Eugeen , Hampel Harald ,   the Neurodegeneration Precision Medicine Initiative (NPMI)
Published: September 2022

AbstractIntroductionThis increasing body of literature indicates that menopause hormonal replacement therapy (MHT) may substantially mitigate the risk of developing late‐life cognitive decline due to progressive Alzheimer's disease (AD) pathophysiology. For the first time, we investigated the question whether MHT impacts AD biomarker‐informed pathophysiological dynamics in de‐novo diagnosed menopausal women.MethodsWe analyzed baseline and longitudinal differences between MHT‐taking and ‐not women in terms of concentrations of core pathophysiological AD plasma biomarkers, validated in symptomatic and cognitively healthy individuals, including biomarkers of (1) the amyloid‐β (Aβ) pathway, (2) tau pathophysiology, (3) neuronal loss, and (4) axonal damage and neurodegeneration.ResultsWe report a prominent and significant treatment response at the Aβ pathway biomarker level. Women at genetic risk for AD (APOE e4 allele carriers) have particularly shown favorable results from treatment.DiscussionTo our knowledge, we present first prospective clinical evidence on effects of MHT on AD pathophysiology during menopause.
Scalable Electrosynthesis of Formamide through C−N Coupling at the Industrially Relevant Current Density of 120 mA cm−2
Authors: Shao Jiang , Meng Nannan , Wang Yuting , Zhang Baoshun , Yang Kaiwen , Liu Cuibo , Yu Yifu , Zhang Bin 
Published: September 2022

AbstractThe scalable and durable electrosynthesis of high‐valued organonitrogen compounds from carbon‐ and nitrogen‐containing small molecules, especially operating at a high current density, is highly desirable. Here, a one‐pot electrooxidation method to synthesize formamide (HCONH2) from methanol and ammonia over a commercial boron‐doped diamond (BDD) catalyst is reported. The formamide selectivity from methanol and formamide Faradaic efficiency (FE
) achieve 73.2 % and 41.2 % at the current density of 120 mA cm−2 with high durability. The C−N bond originates from the nucleophilic attack of ammonia on an aldehyde‐like intermediate. Impressively, an 8 L electrolyzer is employed for the pilot plant test over a 2200 cm2 BDD electrode, which exhibits 33.5 % FE
at 120 mA cm−2 (current: 264 A) with a yield rate of 36.9 g h−1, demonstrating the potential of this technique for large‐scale electrosynthesis of formamide.
Approach to microalgal biodiesel production: Insight review on recent advancements and future outlook
Authors: Yadav Meena , Sharma Yogesh Chandra 
Published: September 2022

AbstractThe environmental concerns about fossil energy and rising oil prices are regular global phenomena. In such an exigency where fossil fuel sources are dwindling, carbon‐neutral biodiesel derived from microalgae lipid seems to be an important renewable energy resource. In recent years, microalgae have become a lucrative feedstock for economically viability of commercial‐scale biofuel production owing to its high biomass growth and high oil yield compared with other crops. The screening and selection of promising microalgae strain should be based on their fatty acid profile and culture conditions. The laboratory to pilot scale culture of microalgae species requires systematic experimental designs to maximize microalgal growth using open or raceway ponds, closed photo bioreactors and hybrid systems. The pros and cons of each harvesting technique, including filtration, centrifugation, sedimentation and flocculation as well cell disruption by thermal, mechanical, chemical and biological techniques, are deliberated in details. Furthermore, the application of homogeneous, heterogeneous and enzyme catalysts in transesterification processes as well as purification technologies are emphasized to ensure high‐quality biodiesel production as per ASTM norms. Microalgae comprise a potential feedstock and biodiesel synthesis from them requires a series of complex up‐streaming and down‐stream processes which are inherently disadvantageous in technology transfer from laboratory to industrial scale. This review paper is mainly focused on microalgal cultivation, harvesting, oil extraction, biodiesel production and purification technologies, and each vital process is critically reviewed in each step. © 2022 Society of Chemical Industry and John Wiley & Sons, Ltd.
Drug library screening identifies histone deacetylase inhibition as a novel therapeutic strategy for choriocarcinoma
Authors: Watanabe Eri , Yokoi Akira , Yoshida Kosuke , Sugiyama Mai , Kitagawa Masami , Nishino Kimihiro , Yamamoto Eiko , Niimi Kaoru , Yamamoto Yusuke , Kajiyama Hiroaki 
Published: September 2022

AbstractBackgroundChoriocarcinoma is a rare and aggressive gynecological malignancy. The standard treatment is systemic chemotherapy as choriocarcinoma exhibits high chemosensitivity. However, refractory choriocarcinoma exhibits chemoresistance; thus, the prognosis remains very poor. This study aimed to identify novel therapeutic agents for choriocarcinoma by utilizing a drug repositioning strategy.MethodsThree choriocarcinoma cell lines (JAR, JEG‐3, and BeWo) and a human extravillous trophoblast cell line (HTR‐8/SVneo) were used for the analyses. The growth inhibitory effects of 1,271 FDA‐approved compounds were evaluated in vitro screening assays and selected drugs were tested in tumor‐bearing mice. Functional analyses of drug effects were performed based on RNA sequencing.ResultsMuti‐step screening identified vorinostat, camptothecin (S, +), topotecan, proscillaridin A, and digoxin as exhibiting an anti‐cancer effect in choriocarcinoma cells. Vorinostat, a histone deacetylase inhibitor, was selected as a promising candidate for validation and the IC50 values for choriocarcinoma cells were approximately 1 μM. RNA sequencing and subsequent pathway analysis revealed that the ferroptosis pathway was likely implicated, and key ferroptosis‐related genes (i.e., GPX4, NRF2, and SLC3A2) were downregulated following vorinostat treatment. Furthermore, vorinostat repressed tumor growth and downregulated the expression of GPX4 and NRF2 in JAR cell‐bearing mice model.ConclusionVorinostat, a clinically approved drug for the treatment of advanced primary cutaneous T‐cell lymphoma, showed a remarkable anticancer effect both in vitro and in vivo by regulating the expression of ferroptosis‐related genes. Therefore, vorinostat may be an effective therapeutic candidate for patients with choriocarcinoma.
Clinicopathologic characteristics, outcomes, and prognostic factors of angioimmunoblastic T‐cell lymphoma in China
Authors: Wei Chong , Li Wei , Qin Liping , Liu Shan , Xue Chang , Ren Kexing , Zhang Zirong , Liu Caili , Bao Fang , Zhang Huilai , Zhou Hui , Li Zhiming , Wu Huijing , Zou Liqun , Liu Lihong , Jing Hongmei , Zhang Wei 
Published: September 2022

AbstractBackgroundThis study aimed to better characterize the clinicopathologic characteristics, outcomes, and prognostic factors of AITL in China.MethodsWe retrospectively analyzed 312 patients with AITL enrolled between January 2011 and December 2020 from five institutions in China.ResultsThe median age was 65 years, with 92.6% advanced stage, 59.7% elevated LDH, 46.1% anemia, and 44.0% hypergammaglobulinemia. The majority of patients (84.9%) received anthracycline‐based regimens with or without etoposide, and only 6.1% underwent autologous stem cell transplantation following first remission. The 5‐year OS and PFS estimates were 43.4% and 25.0% with no significant improvement of survival between patients treated during 2011–2015 and 2016–2020, respectively. Both the International Prognostic Index (IPI) and the prognostic index for PTCL, not otherwise specified (PIT), were predictive for OS. In multivariate analysis, age >70 years, elevated LDH, and albumin level <35 g/L were independent prognostic factors for OS. Combining these three factors, a novel prognostic model (the Chinese AITL score) was constructed, which stratified patients into low‐, intermediate‐, and high‐risk groups, with 5‐year OS rates of 69.0%, 41.5%, and 23.7%, respectively. This new model was successfully validated in an independent cohort.ConclusionsPatients with AITL were mainly treated with anthracycline‐based regimens, and the outcomes were still unsatisfactory in China. Our novel prognostic model may improve our ability to identify patients at different risks for alternative therapies.
Neoadjuvant androgen deprivation therapy combined with abiraterone acetate in patients with locally advanced or metastatic prostate cancer: When to perform radical prostatectomy?
Authors: Xu Ziyang , Wei Fukun , Wang Jie , Ma Sai , Kan Yi , Li Bingheng , Qi Nienie , Mao Lijun 
Published: September 2022

AbstractThe surgical timing after neoadjuvant androgen‐deprivation therapy (ADT) plus abiraterone acetate (AA) for patients with locally advanced or metastatic prostate cancer (PCa) is unknown. We divided patients with locally advanced or metastatic PCa into three groups according to prostate‐specific antigen (PSA) nadir after neoadjuvant ADT plus AA: group 1 (PSA ≤ 0.2 ng/ml), group 2 (0.2 < PSA ≤ 4.0 ng/ml), and group 3 (PSA > 4.0 ng/ml).The median PSA baseline levels in groups 1, 2, 3 were 118.42 (32.03–457.78), 143.48 (17.7–8100.16), and153.35 (46.44–423.31) ng/ml, respectively. The median times of progression to CRPC in groups 1, 2,and 3 were 30, 26, and 26 months, respectively. Compared to patients with PSA nadir >0.2 ng/ml, patients with PSA nadir <0.2 ng/ml presented with longer PFS (p = 0.048).Our results suggested that, in patients with locally advanced or metastatic PCa, the time to progression to CRPC was longer after radical prostatectomy when PSA decreased below 0.2 ng/ml using neoadjuvant ADT plus AA.
Unusual case of broad ligament leiomyoma: A diagnostic and surgical challenge
Authors: Lodhia Jay , Gaffur Raziya , Sadiq Adnan , Amsi Patrick , Tsandiraki Justin , Maro Eusebious 
Published: September 2022

AbstractExtra‐uterine leiomyoma (EUL) is extremely rare and due to its unusual location, results into diagnostic dilemma and due to its unusual location may lead to surgical complication as in this case. We present a case of large broad ligament leiomyoma in a 40‐year‐old premenauposal that was excised with challenges.
Experimental investigation on dynamic behaviour of bubbles emerging from micro‐capillary orifice in a flow channel
Authors: Guo Chenglong , Chai Wang , Lyu Qian , Min Ming , Wang Wei , Liang Lin 
Published: September 2022

AbstractThe flow phenomenon of liquid with bubbles is widespread in various industrial fields, which determines the mass transfer characteristics of the equipment. In this work, the dynamic behaviour of bubbles emerging from micro‐capillary orifice in a flow channel was studied by a visualization experiment, while the effects of gas flow rate and liquid flow rate on these processes of bubble growth, departure, and inrush were explored. The experimental results showed that one bubble formation cycle can be divided into three stages: Waiting, departure, and inrush, as well as the dynamic behaviour of bubble emerging from micro‐capillary orifice in a flow channel, were significantly affected by gas flow rate and liquid flow rate. At a higher gas flow rate, the growth time and the departure time were shorter, as well as the departure volume of the leading bubble and the inrush volume of the trailing bubble were smaller, while the transverse longitudinal ratio fluctuated more violently, and the swing amplitude of the bubble centroid was greater. With an increasing liquid flow rate, the growth time, the departure time, and the inrush time shortened, while the departure volume of the leading bubble decreased and the fluctuation of the bubble centroid weakened. These findings are conducive to improving the performance of the equipment by optimizing the design of the aerator to regulate the dynamic behaviour of bubbles.
Comparative evaluation of the postbleaching application of sodium ascorbate, alpha‐tocopherol, and quercetin on shear bond strength of composite resin to enamel
Authors: Moradian Marzieh , Saadat Maryam , S. Shiri Mohammad Hossein , Sohrabniya Fatemeh 
Published: September 2022

AbstractObjectiveThis study aimed to evaluate and compare the impacts of the postbleaching application of sodium ascorbate, alpha‐tocopherol, and quercetin on the shear bond strength (SBS) of composite resin.Material and Methods60 extracted intact maxillary first premolars were collected and were randomly divided into five experimental groups as follows (n=12): Group A (negative control): no bleaching, Group B (positive control): bleaching with 40% hydrogen peroxide (HP), Group C: HP±10% sodium ascorbate for 10min, Group D: HP±10% alpha‐tocopherol for 10min, and Group E: HP±1% quercetin for 10min. Composite bonding was done immediately after bleaching for Groups B‐E and without any treatment for Group A. After being stored in distilled water at room temperature for 24h, all specimens were tested for SBS in the universal testing machine. One‐way analysis of variance and Tukey's post‐hoc test were used to analyze the SBS values of all groups.ResultsThe results showed that the bonding of composite to the unbleached group exhibited the highest mean value of SBS (22.68±2.91MPa). Among the antioxidant‐treated groups, the highest SBS value was detected in quercetin‐treated specimens (15.45±1.58MPa), which was significantly different from the positive control group (p<.05).ConclusionIt could be concluded that 10% quercetin applied for 10min increased the bond strength to bleached enamel, but it was not able to reverse it completely.
Are gender‐diverse boards eco‐innovative? The mediating role of corporate social responsibility strategy
Authors: Issa Ayman , Bensalem Nasrine 
Published: September 2022

AbstractDespite the recognized importance of board gender diversity and eco‐innovation, it is far from clear how board gender diversity can improve eco‐innovation. Grounded in upper echelon theory and the gender socialization theory, we suggest that this relationship operates through corporate social responsibility (CSR) strategy. In a sample of FTSE 350 firms, we find that CSR strategy mediates the influence of the board's gender diversity on eco‐innovation. These findings are robust to several regression specifications and alternative samples. This work offers empirical evidence that gender diversity on boards can play a significant role in promoting firm's CSR strategy, which in turn improves eco‐innovation. Our findings could provide useful insights for regulators and stakeholders concerned with enhancing corporate governance structure and promoting eco‐innovation.