bluuebunny/crossref_metadata_2025_split huggingface dataset:
“A Stern Language of Beauty”: Ecological Grief and Ecofeminist Ethics in Paula Meehan’s Poetry
Authors: Du Jun 
Published: February 2022

AbstractThrough publicly mourning the loss of family members, communities, and natural habitats, Paula Meehan’s poems de-privatize and politicize grieving and lamentation, functioning in resistance to the existing social and cultural norms. From Reading the Sky (1985) to As If By Magic (2020), Meehan has been conscious of and has continuously delineated the deterioration of the ecosystem due to the exploitative expansion of human society. Drawing on ecofeminist theories and Judith Butler’s theorizations of precariousness and grievability, the essay explores how Meehan depicts ecological grief and the interrelationship between human and nonhuman beings at different stages of her poetic career; it further probes how she illuminates and complicates the ethics of mourning and ecofeminism in her ecological elegies.
Antibiotic susceptibility of Bacillus velezensis
Authors: Heo Ganghun , Kong Haram , Kim Namwon , Lee Sugyeong , Sul Sooyoung , Jeong Do-Won , Lee Jong-Hoon 
Published: February 2022

ABSTRACT
We evaluated the antibiotic minimum inhibitory concentrations (MICs) of 123 Bacillus velezensis strains predominantly isolated from fermented soybean foods from Korea. When the 2018 European Food Safety Authority breakpoint values for Bacillus spp. were applied, all the strains were sensitive to chloramphenicol, clindamycin, erythromycin, gentamicin, kanamycin, tetracycline and vancomycin, and eight strains (6.5%) were resistant to streptomycin. The population distribution in MIC tests with streptomycin was continuous and the profile was clearly different from that expected for acquired antibiotic resistance. As of 25 October 2021, there were 181 complete published genomes of B. velezensis strains; 175 (96.7%) and 136 (75.2%) of these strains, respectively, possess potential tetracycline and streptomycin resistance genes tetL and ant(6) in the chromosome. In Bacillus licheniformis, SpeG confers resistance to clindamycin and there is an ‘speG’ gene annotated in the genomes of 180 B. velezensis strains; however, the gene products exhibit ≤26.6% amino acid identity with that from B. licheniformis DSM 13T. All the potential antibiotic resistance genes in the 181 B. velezensis strains were intrinsic, and traits of lateral gene transfer were not found. In this context, B. velezensis may not present a high risk in terms of antibiotic resistance in food fermentation or human use.
Synergistic effects of plant hormones on spontaneous late-ripening mutant of ‘Jinghong’ peach detected by transcriptome analysis
Authors: Zhang Man , Du Tingting , Yin Yarui , Cao Hongyan , Song Zhihua , Ye Mao , Liu Yating , Shen Yanhong , Zhang Libin , Yang Qing , Meng Dong , Wu Junkai 
Published: February 2022

Abstract

Objectives
Peach (Prunus persica L.) is an ancient fruit tree that originated from China. It is the climacteric fruit belonging to genus Prunus in family Rosaceae. Ethylene, which is produced during ripening, accelerates fruit softening, and therefore peaches cannot be stored for a long time.

Materials and Methods
To study the mechanism of fruit late ripening, transcriptome analysis of the fruit of a late-ripening mutant of ‘Jinghong’ peach was performed to identify genes and pathways involved in fruit late ripening.

Results
A total of 1805, 1511, and 2309 genes were found to be differentially expressed in W2_vs_M1, W3_vs_M2, and W3_vs_M3, respectively. Functional enrichment analysis of the differentially expressed genes showed they were related to carotenoid biosynthesis, starch and sucrose metabolism plant hormone signal transduction, flavonoid biosynthesis, and photosynthesis. The expression trends of ripening-related genes that encode transcription factors and plant hormone signal transduction-related genes that encode enzymes were similar.

Conclusions
It will help to elucidate the transcriptional regulatory network of fruit development in the spontaneous late-ripening mutant of ‘Jinghong’ peach and provide a theoretical basis for understanding the molecular regulatory mechanism of fruit ripening.
Genetic mapping of loci involved in oil tocopherol composition control in Russian sunflower (Helianthus annuus L.) lines
Authors: Gubaev Rim , Boldyrev Stepan , Martynova Elena , Chernova Alina , Kovalenko Tatyana , Peretyagina Tatyana , Goryunova Svetlana , Goryunov Denis , Mukhina Zhanna , Ben Cecile , Gentzbittel Laurent , Khaitovich Philipp , Demurin Yakov 
Published: February 2022

Abstract
Tocopherols are antioxidants that preserve oil lipids against oxidation and serve as a natural source of vitamin E in the human diet. Compared with other major oilseeds like rapeseed and soybean, sunflower (Helianthus annuus L.) exhibits low phenotypic diversity of tocopherol composition, both in wild and cultivated accessions from germplasm collections. Two major mutations that alter tocopherol composition were identified in genetic collections, and several studies suggested additional loci controlling tocopherol composition, with their expression possibly depending on the genetic background. In the present study, we performed QTL mapping of tocopherol composition in two independent F2 crosses between lines with contrasting tocopherol composition from the Pustovoit All-Russia Research Institute of Oil Crops (VNIIMK) collection. We used genotyping-bysequencing (GBS) to construct single nucleotide polymorphism-based genetic maps, and performed QTL mapping using quantitative and qualitative encoding for phenotypic traits. Our results support the notion that the tocopherol composition in the assessed crosses is controlled by two loci. We additionally selected and validated two single nucleotide polymorphism markers for each cross which could be used for marker-assisted selection.
Improving genomic predictions with inbreeding and nonadditive effects in two admixed maize hybrid populations in single and multienvironment contexts
Authors: Roth Morgane , Beugnot Aurélien , Mary-Huard Tristan , Moreau Laurence , Charcosset Alain , Fiévet Julie B 
Published: February 2022

AbstractGenetic admixture, resulting from the recombination between structural groups, is frequently encountered in breeding populations. In hybrid breeding, crossing admixed lines can generate substantial nonadditive genetic variance and contrasted levels of inbreeding which can impact trait variation. This study aimed at testing recent methodological developments for the modeling of inbreeding and nonadditive effects in order to increase prediction accuracy in admixed populations. Using two maize (Zea mays L.) populations of hybrids admixed between dent and flint heterotic groups, we compared a suite of five genomic prediction models incorporating (or not) parameters accounting for inbreeding and nonadditive effects with the natural and orthogonal interaction approach in single and multienvironment contexts. In both populations, variance decompositions showed the strong impact of inbreeding on plant yield, height, and flowering time which was supported by the superiority of prediction models incorporating this effect (+0.038 in predictive ability for mean yield). In most cases dominance variance was reduced when inbreeding was accounted for. The model including additivity, dominance, epistasis, and inbreeding effects appeared to be the most robust for prediction across traits and populations (+0.054 in predictive ability for mean yield). In a multienvironment context, we found that the inclusion of nonadditive and inbreeding effects was advantageous when predicting hybrids not yet observed in any environment. Overall, comparing variance decompositions was helpful to guide model selection for genomic prediction. Finally, we recommend the use of models including inbreeding and nonadditive parameters following the natural and orthogonal interaction approach to increase prediction accuracy in admixed populations.
Interpersonal Discussion and Political Knowledge: Unpacking the Black Box via a Combined Experimental and Content-Analytic Approach
Authors: Moore Ryan C , Coronel Jason C 
Published: February 2022

AbstractOver 130 studies have examined the relationship between interpersonal political discussion and political knowledge, generally finding that discussion can increase people’s level of political knowledge (Amsalem & Nir, 2019). However, two important questions remain unanswered: (a) Do some types of political discussions facilitate greater levels of political knowledge than others? (b) Do people retain knowledge gained from political discussions? In this study (N = 96), we addressed these questions using a novel methodological approach that combines a lab experiment, in which we manipulated the occurrence of political discussion, with a systematic content analysis of participants’ discussions (N = 1,080 distinct instances of discussions). We found that discussions involving confirmatory feedback and cueing were associated with greater levels of political knowledge than other types of discussions. Furthermore, knowledge gains from discussion were not retained after a short delay. Our study lays the theoretical and methodological groundwork for future investigations into the “black box” of political discussion.
Here for the Right Reasons: The Selection of Women as Peace Delegates
Authors: Brannon Elizabeth , Best Rebecca 
Published: February 2022

AbstractSince the passing of the United Nations Security Council Resolution 1325 on women, peace, and security more than two decades ago, there has been a global push to bolster the inclusion of women in these processes. When women are selected into peace delegations for the wrong reasons, they—like men—can hinder or stall progress. Yet, very little work has analyzed which women are included in peace processes, how they are selected, why they are selected, and how their individual experiences influence both their behavior and the outcomes of those processes. We identify four selection criteria used to select participants in negotiations: (1) reliability as assessed through either connections to elites or ideological purity; (2) qualifications such as experience in the armed forces, rebel forces, civil society, or academia; (3) personal appeal or ability to elicit sympathy based on factors such as victimhood, attractiveness, youth, or demographics; and (4) selection by a third party whose strength and size have allowed it to negotiate representation in the process. It is likely that in many cases, multiple motives and selection criteria are at play in the selection of individual women (or men). We consider how gender impacts the implementation of these criteria, drawing on a variety of peace processes, but especially the Havana Peace Talks between the Colombian government and Fuerzas Armadas Revolucionarios Colombianos–Ejército del Pueblo. This framework sets the foundation for the development of three research agendas: the first relating to which women get a seat at the table, the second to how the individual backgrounds of the women selected into the peace process influence outcomes, and the third to issues of intersectionality and representation.
Management of elderly patients with head and neck cancer
Authors: Ishii Ryo , Ohkoshi Akira , Kiyota Naomi , Matsuura Kazuto , Yasuda Koichi , Imamura Yoshinori , Saito Yuki , Homma Akihiro ,   the Japan Clinical Oncology Group (JCOG) Head and Neck Cancer Study Group
Published: February 2022

Abstract
There are no established guidelines for managing older patients with head and neck cancer. Most clinical trials that define current standard therapy included few elderly patients. On the other hand, there is great variability in patients’ comorbidities, physical functions, cognitive function, familial and financial background and values. The key point appears to be appropriate geriatric assessment, clarifying the patients’ outcomes and a multidisciplinary team approach, including the treatment decision-making policy. Although these processes should be scientific in nature, the evidence for the treatment of elderly head and neck patients is very limited.
This review summarizes the evidence available regarding the management of geriatric assessment, each treatment modality and the multidisciplinary team approach for older patients with head and neck cancers.
The prognostic impact of preoperative mean corpuscular volume in colorectal cancer
Authors: Nakamura Kimihiko , Seishima Ryo , Matsui Shimpei , Shigeta Kohei , Okabayashi Koji , Kitagawa Yuko 
Published: February 2022

Abstract

Objective
The relationship between preoperative mean corpuscular volume and postoperative prognosis has been reported in some cancers recently, but no certain consensus has been reached, especially for colorectal cancer. We evaluated the usefulness of mean corpuscular volume as a prognostic factor in colorectal cancer patients.

Methods
This study included 1003 patients with colorectal cancer who underwent curative surgery in a single institution. The relationship between mean corpuscular volume values and postoperative recurrence was evaluated by fractional polynomial model. Based on the result, patients were divided into groups according to mean corpuscular volume values. Clinicopathological factors and long-term outcomes were compared between the groups.

Results
The risk of postoperative recurrence according to mean corpuscular volume value showed a J-shaped curve, suggesting that both low and high mean corpuscular volume have high risk. Low mean corpuscular volume (≤84 fl) group was oncologically advanced in terms of pathological tumor stage, histological grade and lymphatic invasion with higher inflammation markers. High mean corpuscular volume (&gt;95 fl) group had higher frequency of drinking habit with higher values of aspartate aminotransferase, alanine aminotransferase and γ-glutamyl transpeptidase. Abnormal mean corpuscular volume group including these two groups showed significantly worse disease-free survival than the other (P &lt; 0.001). Multivariate analysis suggested that abnormal mean corpuscular volume was an independent risk factor for postoperative recurrence (hazard ratio, 1.344; 95% confidence interval, 1.005–1.796; P = 0.046). Furthermore, its prognostic impact was more significant in pStage III than in other stages.

Conclusion
Preoperative low and high mean corpuscular volume is a poor prognostic factor in colorectal cancer patients. It could be a predictive marker to estimate worse survival outcome after surgery.
Association of Personal Characteristics and Effectiveness of Immunotherapy in Late-Stage Non-Small Cell Lung Cancer: A Systematic Review
Authors: Patel Krishna , Alpert Naomi , Tuminello Stephanie , Taioli Emanuela 
Published: February 2022

Abstract

Background
Although immunotherapy can increase survival in non-small cell lung cancer (NSCLC), response rates are low. It is unclear which characteristics contribute to variability in immunotherapy efficacy and survival. Research is needed to identify reasons for heterogeneity in response rates to better tailor treatments.

Methods
Web of Science, Ovid EMBASE, and MEDLINE were queried from 2013 to January 2021, and all studies reporting overall or progression-free survival for patients treated with immunotherapy for NSCLC of at least stage IIIB were screened.

Results
Included were 18 randomized controlled trials (RCTs; 6534 immunotherapy RCTs; 11 192 nonimmunotherapy RCTs) and 16 observational studies (n = 9073 immunotherapy patients). Among RCTs, there was improved survival with the addition of immunotherapy in patients aged younger than 65 years in 10 of 17 studies; smokers in 8 of 15 studies; and males in 10 of 17 studies and 6 of 17 females. Only 5 studies reported outcomes by race. Among observational studies, younger patients (aged younger than 60, younger than 65, or younger than 70 years in most studies) had better survival than older patients (aged 60 years and older, 65 years and older, or 70 years and older) in 4 of 13 studies, ever-smokers in 7 of 13, and females in 2 of 14. Three studies reported race with mixed results.

Conclusion
Although evidence is mixed, younger patients, smokers, and males may derive more benefit from immunotherapy. Evidence on racial differences is limited. Physicians should be mindful of personal characteristics when formulating treatment plans. Further research is needed to understand underlying mechanisms and to identify the best immunotherapy candidates and alternative treatments for those unlikely to benefit.
Patterns of Objectively Measured Sedentary Time and Emotional Disorder Symptoms Among Youth
Authors: Zink Jennifer , Yang Chih-Hsiang , McAlister Kelsey L , Huh Jimi , Pentz Mary Ann , Page Kathleen A , Belcher Britni R , Dunton Genevieve F 
Published: February 2022

Abstract

Objective
We examined the within-person longitudinal and bidirectional associations between patterns of sedentary time accumulation [alpha (sedentary bout duration/length), sedentary breaks (number of breaks in sedentary bouts)], and symptoms of major depressive disorder and generalized anxiety disorder.

Methods
Children [N = 167, 10.1(0.9) years old, 54.5% female, 59.3% Hispanic, 35.9% overweight/obese at baseline] participated in a 3-year longitudinal study that consisted of assessments of sedentary time, and depressive and anxiety symptoms. At each assessment, participants wore accelerometers and completed the Revised Child Anxiety and Depression Scale. Separate random intercept cross-lagged panel models estimated the within-person longitudinal and bidirectional associations between alpha, sedentary breaks, and symptoms of major depressive disorder and generalized anxiety disorder across chronological age intervals.

Results
Having greater than one’s own usual depressive symptoms at age 11 was associated with fewer sedentary breaks 1 year later. Having greater than one’s own usual generalized anxiety symptoms at age 11 was associated with longer sedentary bouts and fewer sedentary breaks 1 year later. In contrast, having greater than one’s own usual sedentary breaks at age 10 was associated with fewer generalized anxiety symptoms 1 year later. All other associations, including at younger ages, were null.

Conclusion
Deviations from one’s usual levels of depressive or anxiety symptoms may be important for how sedentary time is subsequently accumulated. Intraindividual processes appear to be at play, therefore more within-person research is needed. Intervention strategies for promoting a healthier accumulation of sedentary time may consider targeting occasions when depressive and anxiety symptoms are greater than usual.
Phytochemical profile and protective effects on myocardial ischaemia-reperfusion injury of sweated and non-sweated Salvia miltiorrhiza. Bge alcoholic extracts
Authors: Shan Xiaoxiao , Xiao Yaoyao , Hong Bangzhen , Li Ling , Chen Yueting , Wang Guokai , Yu Nianjun , Peng Daiyin , Zhang Caiyun , Wang Lei , Chen Weidong 
Published: February 2022

Abstract

Objectives
This study aims to compare the fingerprint and the content of the three components of sweated and non-sweated Salvia miltiorrhiza alcoholic extracts (SSAE and NSAE). It also aims to investigate the difference in protective effects of SSAE and NSAE on myocardial ischaemia-reperfusion injury (MIRI).

Methods
The fingerprints of SSAE and NSAE were established by HPLC with a UV detector to identify the common peaks and detect the content of the three major components (cryptotanshinone, tanshinone I and tanshinone IIA). The protective effects of SSAE and NSAE were compared with MIRI rat model after orally administered SSAE and NSAE (2 g/kg of raw drug) for 7 days. The ST segment, PR and QT interval changes and the infarct size were assessed in the rat hearts. Moreover, the activity of aspartate transaminase (AST), lactate dehydrogenase (LDH), superoxide dismutase (SOD) and the level of cardiac troponin I (cTn I) in serum as well as the cardiac H&E staining were evaluated.

Key findings
The results showed that the fingerprints of SSAE and NSAE were similar, and cluster analysis showed that the sweating methods had effects on the alcoholic extracts. The content determination showed that sweating could increase the total content of cryptotanshinone, tanshinone I and tanshinone IIA of S. miltiorrhiza. The results of electrocardiograms (ECG) showed that SSAE could make the ST segment drop more obviously, PR and QT intervals become shorter, and the size of the infarct much smaller. Compared with NSAE, SSAE had more significant effects on the enzymatic activity of AST, LDH and the level of cTn I in serum. The H&E staining showed that both SSAE and NSAE could reduce the degree of heart damage.

Conclusions
The present investigation results demonstrated that sweating increased the content of tanshinone components in S. miltiorrhiza alcoholic extracts, and SSAE had a better protective effect on MIRI.
Swinburne’s Boyishness
Authors: Selleri Andrea 
Published: February 2022

Abstract
This article reconsiders the early critical reception of Algernon Charles Swinburne’s 1866 collection Poems and Ballads with a view to articulating the extent to which the critical hostility that famously greeted the book upon publication was mediated by the category of ‘boyishness’. I show that the complaint that the 29-year-old Swinburne wrote, and by implication thought and felt, too much like a boy and not enough like an adult man lay at the core of the critical onslaught and contributed to underpin critics’ various complaints of obscenity, blasphemy, bad taste and so on. After considering the nature of the connection between the boyish quality often associated with Swinburne as a person throughout his life and the poetical ‘boyishness’ critics perceived in his work, I propose a taxonomy of three main meanings of boyishness that emerge from the early critics’ attacks: boyishness as lack of virility, boyishness as lack of self-restraint, and boyishness as lack of intellectual maturity. By analysing these critical readings in the context of various medical, pedagogical and more broadly cultural discourses of the time, I make the case that Swinburne found himself cast as someone who presented precisely the characteristics of boyhood of which a functioning adult man was supposed to rid himself. The broader argument is that by giving close attention to age-based slurs, we can gain a more fine-grained account of mid-Victorian attitudes to childhood and maturity, and society’s self-image more generally.