bluuebunny/crossref_metadata_2025_split huggingface dataset:
Highway traffic flow prediction model with multi-component spatial–temporal graph convolution networks
Authors: Ning Tao , Han Yumeng , Wang Jiayu 
Published: December 2022

AbstractIn order to effectively solve the problems of redundant medical material allocation, unbalanced material allocation, high distribution cost and lack of symmetry caused by unreasonable prediction in the case of sudden epidemic disasters, the prospect theory is introduced to establish a two-stage robust allocation model of medical materials, and the HQDRO based on the two-stage decision model is proposed. Aiming at minimizing the emergency response time and the total number of allocated materials, and taking the dynamic change of medical material demand in the epidemic sealed control area as the constraint condition, a two-stage robust planning model of medical materials based on scenario is established to realize the symmetrical allocation of medical materials under the sudden epidemic situation. Then, the perception model based on demand prediction, symmetry optimization, targeted distribution and psychological expectation of medical materials are constructed. Through the comparative analysis with the fitness of three commonly used algorithms in this field, the effectiveness of the robust configuration model and HQDRO proposed in this paper is verified.
Peristaltic transport characteristics of a second-grade dusty fluid flown with heat transfer through a tube revisited
Authors: Hafez N. M. , Alsemiry Reima D. , Alharbi Sana A. , Abd-Alla A. M. 
Published: December 2022

AbstractThis paper provides a rudimentary insight into the influence of heat transfer on the transport characteristics of a second-grade dusty fluid flown in a flexible tube with walls subjected to the peristaltic motion. Both dust particles and fluid movements were modeled using the coupled differential equations. The effects of different types of parameters such as Reynolds number, Prandtl number, Grashof number, wave number, wave amplitude ratio, second grade parameter as well as nature of the heat source and sink are studies on the dust particles velocity, fluid velocity, temperature, pressure profiles of the fluid and streamline patterns of the fluid. The derived equations were solved analytically via the standard perturbation method to determine the fluid temperature, streamline pattern and velocity of the dust particles as well as fluid. The values in the increase of pressure and frictional forces were calculated numerically using DSolve of the Mathematica 11 software (https://www.wolfram.com/mathematica/new-in-11/). In addition, the trapping mechanisms were ascertained by computing the streamlines and various physical parameters. The obtained results were validated with the state-of-the-art literature reports. It was claimed that our systematic approach may constitute a basis for accurately examining the impact of heat transfer on the peristaltic transport of a complex fluid through narrow tubes, useful for diverse medical applications such as the gastric fluid flow through the small intestine during endoscopy. Numerical results are computed and discussed numerically and presented through graphs. The impacts of pertinent parameters on the aforementioned quantities are examined by plotting graphs on the basis of computational results. The results indicate that the effect of parameters is very pronounced. A suitable comparison has been made with the prior results in the literature as a limiting case of the considered problem.
Sclerostin as a biomarker of cardiovascular risk in women with systemic lupus erythematosus
Authors: Garcia-de los Ríos Carlos , Medina-Casado Marta , Díaz-Chamorro Antonio , Sierras-Jiménez María , Lardelli-Claret Pablo , Cáliz-Cáliz Rafael , Sabio José Mario 
Published: December 2022

AbstractCardiovascular disease is one of the main causes of death in patients with systemic lupus erythematosus (SLE). On the other hand, sclerostin is a reliable and early biomarker of vascular calcification. This study aimed to estimate the association between sclerostin and two markers of cardiovascular risk, carotid atherosclerotic plaque (CP) and carotid-femoral pulse wave velocity (PWV), in women with SLE. The presence of CP (determined by carotid artery ultrasound) and PWV were measured in 68 women with SLE and preserved renal function. None of the participants had a history of cardiovascular disease. Serum levels of sclerostin were determined using the ELISA method. Other factors associated with increased cardiovascular risk were also measured. The association between sclerostin, CP and PWV was assessed using Receiver Operating Characteristic (ROC) curves and multivariate regression models. The area under the ROC curve was 0.785 (95% confidence interval [CI] 0.662–0.871) for CP and 0.834 (95% CI 0.729–0.916) for dichotomized PWV. After adjusting for other cardiovascular risk factors, it was found that a 10-units increase in sclerostin values was associated with a 44% increase in the odds of CP (95% CI 1–105), but no adjusted association was observed between sclerostin and PWV. Predictive models included age (for both outcomes), hypertension, Framingham risk score and C-reactive protein (for PWV), but not sclerostin. Sclerostin is associated with the presence of CP in women with SLE. Further research should confirm its possible role as a biomarker of cardiovascular risk in these patients.
Adaption and implementation of the engage programme within the early childhood curriculum
Authors: Healey Dione , Milne Barry , Healey Matthew 
Published: December 2022

AbstractPoor self-regulation has been associated with an array of adverse outcomes including difficulties with school transition, educational attainment, and social functioning in childhood, and employment, mental health, physical health, relationships, and criminal activity in adulthood. Enhancing Neurobehavioural Gains with the Aid of Games and Exercises (ENGAGE) is a play-based intervention fostering the development of self-regulation in pre-schoolers and has led to improvements within the home setting. The aim for this study was to ascertain whether ENGAGE can be implemented within an Early Childhood Education (ECE) group setting and whether this leads to improved self-regulation. This trial has been registered with the Australian New Zealand Clinical Trials Registry (ANZCTR); trial number ACTRN12622000364774; trial web address: https://www.anzctr.org.au/ACTRN12622000364774.aspx. 668 children aged 3–5 years and their teachers, across 28 ECEs participated. Children’s self-regulation skills were assessed via scores on the Hyperactivity, Aggression, and Attention Problems subscales of BASC-2. Results indicted no significant changes in self-regulation skills across a 10-week waitlist period. Following 10 weeks of the ENGAGE programme, significant improvements in self-regulation were reported, and these were maintained at 2- and 6-month follow-up. These findings indicate that ENGAGE translates well into the ECE setting and has the potential to have population-based impacts which could lead to more positive societal outcomes.
In vitro assessment of probiotic attributes for strains contained in commercial formulations
Authors: Mazzantini Diletta , Calvigioni Marco , Celandroni Francesco , Lupetti Antonella , Ghelardi Emilia 
Published: December 2022

AbstractAlthough probiotics are often indiscriminately prescribed, they are not equal and their effects on the host may profoundly differ. In vitro determination of the attributes of probiotics should be a primary concern and be performed even before clinical studies are designed. In fact, knowledge on the biological properties a microbe possesses is crucial for selecting the most suitable bacteriotherapy for each individual. Herein, nine strains (Bacillus clausii NR, OC, SIN, T, Bacillus coagulans ATCC 7050, Bifidobacterium breve DSM 16604, Limosilactobacillus reuteri DSM 17938, Lacticaseibacillus rhamnosus ATCC 53103, and Saccharomyces boulardii CNCM I-745) declared to be contained in six commercial formulations were tested for their ability to tolerate simulated intestinal conditions, adhere to mucins, and produce β-galactosidase, antioxidant enzymes, riboflavin, and d-lactate. With the exception of B. breve, all microbes survived in simulated intestinal fluid. L. rhamnosus was unable to adhere to mucins and differences in mucin adhesion were evidenced for L. reuteri and S. boulardii depending on oxygen levels. All microorganisms produced antioxidant enzymes, but only B. clausii, B. coagulans, B. breve, and L. reuteri synthesize β-galactosidase. Riboflavin secretion was observed for Bacillus species and L. rhamnosus, while d-lactate production was restricted to L. reuteri and L. rhamnosus. Our findings indicate that the analyzed strains possess different in vitro biological properties, thus highlighting the usefulness of in vitro tests as prelude for clinical research.
The effects of inhibition and siRNA knockdown of collagen-binding integrins on human umbilical vein endothelial cell migration and tube formation
Authors: Hunter Emma J. , Hamaia Samir W. , Kim Peter S.-K. , Malcor Jean-Daniel M. , Farndale Richard W. 
Published: December 2022

AbstractBlood vessels in the body are lined with endothelial cells which have vital roles in numerous physiological and pathological processes. Collagens are major constituents of the extracellular matrix, and many adherent cells express several collagen-binding adhesion receptors. Here, we study the endothelium–collagen interactions mediated by the collagen-binding integrins, α1β1, α2β1, α10β1 and α11β1 expressed in human umbilical vein endothelial cells (HUVECs). Using qPCR, we found expression of the α10 transcript of the chondrocyte integrin, α10β1, along with the more abundant α2, and low-level expression of α1. The α11 transcript was not detected. Inhibition or siRNA knockdown of the α2-subunit resulted in impaired HUVEC adhesion, spreading and migration on collagen-coated surfaces, whereas inhibition or siRNA knockdown of α1 had no effect on these processes. In tube formation assays, inhibition of either α1 or α2 subunits impaired the network complexity, whereas siRNA knockdown of these integrins had no such effect. Knockdown of α10 had no effect on cell spreading, migration or tube formation in these conditions. Overall, our results indicate that the collagen-binding integrins, α1β1 and α2β1 play a central role in endothelial cell motility and self-organisation.
Ultra-long air-stability of n-type carbon nanotube films with low thermal conductivity and all-carbon thermoelectric generators
Authors: Amma Yuki , Miura Katsuma , Nagata Sho , Nishi Tsuyoshi , Miyake Shugo , Miyazaki Koji , Takashiri Masayuki 
Published: December 2022

AbstractThis report presents n-type single-walled carbon nanotubes (SWCNT) films with ultra-long air stability using a cationic surfactant and demonstrates that the n-type Seebeck coefficient can be maintained for more than two years, which is the highest stability reported thus far to the best of our knowledge. Furthermore, the SWCNT films exhibit an extremely low thermal conductivity of 0.62 ± 0.08 W/(m·K) in the in-plane direction, which is very useful for thin-film TEGs. We fabricated all-carbon-nanotube TEGs, which use p-type SWCNT films and the n-type SWCNT films developed, and their air-stability was investigated. The TEGs did not degrade for 160 days and exhibited an output voltage of 24 mV, with a maximum power of 0.4 µW at a temperature difference of 60 K. These results open a pathway to enable the widespread use of carbon nanotube TEGs as power sources in IoT sensors.
Bias in sex ratios and polyandry rate in reproduction of Leptinotarsa decemlineata
Authors: Sedláková Vladimíra , Stará Jitka , Čílová Daniela , Melounová Martina , Vašek Jakub , Vejl Pavel , Doležal Petr , Kocourek František , Hausvater Ervín , Sedlák Petr 
Published: December 2022

AbstractThe Colorado potato beetle (CPB,Leptinotarsa decemlineataSlechtd.) is an invasive pest with economic importance worldwide. Sex ratios during egg-hatching and a frequency of polyandry in single-female families were analysed to clarify the reproduction strategy of CPB, which was still known only in fragments. 1296 just hatching 1st instar CPB larvae were collected from 19 single-female families, of which 13 were random families collected from potato fields and 6 were families produced by laboratory farming of naturally fertilised females. All larvae were analysed to detect a sex using a qPCR-based method and to detect polymorphisms in genotypes of 9 microsatellite (SSR) markers. The bias in sex ratio in favour of females was confirmed using linear mixed-effects model in both experimental groups of families: field collections (F = 36.39; P = 0.0001) and laboratory farming (F = 13.74;P = 0.0139). The analysis of diversity in microsatellites proved the polyandry in all progenies as 73% of analysed segregation patterns did not match with the patterns expected for full-sib progenies; on average per locus, 46% of allelic and 49.7% of genotype ratios showed irregular segregation. Both findings contribute toward understanding CPB success rate as an invasive species, as the preferential bearing of females with polyandry has a great potential to keep fitness of progenies, to maintain and operate population diversity, and to accelerate the reproduction of the pest.
Impact of Shiga-toxin encoding gene transduction from O80:H2 Shiga toxigenic Escherichia coli (STEC) on non-STEC strains
Authors: Habets Audrey , Antoine Céline , Wagemans Jeroen , Vermeersch Marjorie , Laforêt Fanny , Diderich Jacob , Lavigne Rob , Mainil Jacques , Thiry Damien 
Published: December 2022

AbstractShiga toxin-producing Escherichia coli (STEC) are major foodborne pathogens that cause human diseases ranging from diarrhea to life-threatening complications including hemolytic–uremic syndrome. Virulence of STEC strains and their ability to cause severe diseases are associated with the activity of prophage-encoded Shiga toxins (Stxs). The first objective of this work was to isolate and characterize the Stx2d phage from STEC O80:H2 and to study the transfer of this phage in non-STEC strains. The second objective was to assess the survival of Galleria mellonella larvae inoculated with these transduced strains. Firstly, one bacteriophage isolated from a STEC O80:H2 strain was used to infect six non-STEC strains, resulting in the conversion of three strains. Then, stability assays were performed, showing that this phage was stable in the new STEC strains after three successive subculturing steps, as confirmed by a combination of short and long read genome sequencing approaches. This phage, vB_EcoS_ULI-O80_Stx2d, is resistant to moderate temperature and pH. It belongs to a currently unclassified genus and family within the Caudoviricetes class, shares 98% identity with Stx2_112808 phage and encodes several proteins involved in the lysogenic cycle. The yecE gene was identified at the insertion site. Finally, G. mellonella experiments showed that the transduced strains caused significantly higher mortality rates than the corresponding non-STEC strains. In conclusion, this study showed that stx2d gene from O80:H2 E. coli can be transferred to non-STEC strains and contributes to their virulence.
Synthesis of coumarin derivatives and investigation of their inhibitory effects on lung cancer cell motility
Authors: Zhou Rui , Yu Young Hyun , Kim Hangun , Ha Hyung-Ho 
Published: December 2022

AbstractBased on the pharmaceutical potentials of coumarins, which have antitumor activity, we synthesized new coumarin derivatives and evaluated their biological activities. The new coumarin derivatives were chemically synthesized from 4-hydroxycoumarin, and their structures were confirmed by nuclear magnetic resonance data. Ten of the synthesized compounds were investigated for antimetastatic activity against lung carcinoma cells. Several of the tested compounds showed good to mild inhibitory effects on lung cancer cell motility. There were no cytotoxic effects related to the use of these compounds. 4-Hydroxycoumarin derivatives, 4h and 4i, elicited the significant inhibitory effect on lung cancer cell motility by suppressing expression of the epithelial–mesenchymal transition markers N-cadherin, Snail, and Twist.
Decentralized reinforce‐control of renewable dynamic virtual power plant enabling it to offer ancillary services: An attempt towards net‐zero targets
Authors: Kumar Lalit , Ahmed Shehab , Naidoo Raj , Bansal Ramesh Chand 
Published: December 2022

AbstractThis article presents internal model control (IMC) based decentralized reinforce‐control of renewable dynamic virtual power plant (DVPP) so that, it can be integrated into the power system as a substitution of fuel‐based conventional generators. Such grid integration towards net‐zero targets could not be possible without providing additional ancillary service (AS) to the power system, as the traditional AS would fall short with the retirement/substitution of conventional generators. The theory of DVPP from a technical perspective (i.e., TDVPP) is presented in a detailed and simplified manner, including the formulation of a generalized control objective (desired specification) for DVPP integration. The solution approach includes two steps: (1) disaggregation of desired specification and (2) decentralized reinforce‐control to match the disaggregated specification. The theory and solution approach for DVPP integration is presented in a generalized manner enabling the DVPP to offer multiple ASs, but the case study is limited only to frequency control AS (FCAS) in this article. The study is performed on the ‘western system coordinating council (WSCC)’ test system, in which an attempt is made towards net‐zero targets by substituting the largest thermal generator with renewable DVPP ensuring the grid's operation or dynamics safe.
Direct driving of simulated planetary jets by upscale energy transfer
Authors: Böning Vincent G. A. , Wulff Paula , Dietrich Wieland , Wicht Johannes , Christensen Ulrich R. 
Published: December 2022

Context. The precise mechanism that forms jets and large-scale vortices on the giant planets is unknown. An inverse cascade has been suggested by several studies. Alternatively, energy may be directly injected by small-scale convection.
Aims. Our aim is to clarify whether an inverse cascade feeds zonal jets and large-scale eddies in a system of rapidly rotating, deep, geostrophic spherical-shell convection.
Methods. We analyze the nonlinear scale-to-scale transfer of kinetic energy in such simulations as a function of the azimuthal wave number, m.
Results. We find that the main driving of the jets is associated with upscale transfer directly from the small convective scales to the jets. This transfer is very nonlocal in spectral space, bypassing large-scale structures. The jet formation is thus not driven by an inverse cascade. Instead, it is due to a direct driving by Reynolds stresses, statistical correlations of velocity components of the small-scale convective flows. Initial correlations are caused by the effect of uniform background rotation and shell geometry on the flows and provide a seed for the jets. While the jet growth suppresses convection, it increases the correlation of the convective flows, which further amplifies the jet growth until it is balanced by viscous dissipation. To a much smaller extent, energy is transferred upscale to large-scale vortices directly from the convective scales, mostly outside the tangent cylinder. There, large-scale vortices are not driven by an inverse cascade either. Inside the tangent cylinder, the transfer to large-scale vortices is even weaker, but more local in spectral space, leaving open the possibility of an inverse cascade as a driver of large-scale vortices. In addition, large-scale vortices receive kinetic energy from the jets via forward transfer. We therefore suggest a jet instability as an alternative formation mechanism of large-scale vortices. Finally, we find that the jet kinetic energy scales approximatively as ℓ−5, the same as for the so-called zonostrophic regime.
Impact of tides on non-coplanar orbits of progenitors of high-mass X-ray binaries
Authors: Simaz Bunzel A. , García F. , Combi J. A. , Fortin F. , Chaty S. 
Published: December 2022

Context. An important stage in the evolution of massive binaries is the formation of a compact object in the system. It is believed that in some cases a momentum kick is imparted to the newly born object, changing the orbital parameters of the binary, such as eccentricity and orbital period, and even acquiring an asynchronous orbit between its components. In this situation, tides play a central role in the evolution of these binaries.
Aims. In this work we aim to study how the orbital parameters of a massive binary change after the formation of a compact object when the stellar spin of the non-degenerate companion is not aligned with the orbital angular momentum.
Methods. We used MESA, which we modified to be able to evolve binaries with different values of the inclination between the orbital planes before and just after the formation of the compact object. These modifications to the equations solved by the MESA code are extended to the case of non-solid body rotation.
Results. We find that the impact of having different initial inclinations is mostly present in the evolution towards an equilibrium state that is independent of the inclination. If the binary separation is small enough such that the interaction happens when the star is burning hydrogen in its core, this state is reached before the beginning of a mass-transfer phase, while for a wider binary not all conditions characterizing the equilibrium are met. We also explore the effect of having different initial rotation rates in the stars and how the Spruit-Tayler dynamo mechanism affects the angular momentum transport for a non-coplanar binary.
Conclusions. These findings show that including the inclination in the equations of tidal evolution to a binary after a kick is imparted onto a newly born compact object changes the evolution of some parameters, such as the eccentricity and the spin period of the star, depending on how large this inclination is. Moreover, these results can be used to match the properties of observed X-ray binaries to estimate the strength of the momentum kick.
Center-to-limb variation of spectral lines and continua observed with SST/CRISP and SST/CHROMIS
Authors: Pietrow A. G. M. , Kiselman D. , Andriienko O. , Petit dit de la Roche D. J. M. , Díaz Baso C. J. , Calvo F. 
Published: December 2022

Context.Observations of center-to-limb variations (CLVs) of spectral lines and continua provide a good test for the accuracy of models with a solar and stellar atmospheric structure and spectral line formation. They are also widely used to constrain elemental abundances, and are becoming increasingly more important in atmospheric studies of exoplanets. However, only a few such data sets exist for chromospheric lines.Aims.We aim to create a set of standard profiles by means of mosaics made with the CRISP and CHROMIS instruments of the Swedish 1-m Solar Telescope (SST), as well as to explore the robustness of said profiles obtained using this method.Methods.For each spectral line, we used a mosaic that ranges from the center to the limb. Each of these mosaics were averaged down to 50 individual spectral profiles and spaced by 0.02 in theμscale. These profiles were corrected for p-mode oscillations, and their line parameters (equivalent width, line shift, full-width at half-maximum, and line depth) were then compared against literature values whenever possible.Results.We present a set of 50 average profiles that are spaced equidistantly along the cosine of the heliocentric angle (μ) by steps of 0.02 for five continuum points between 4001 and 7772 Å, as well as ten of the most commonly observed spectral lines at the SST (Ca II H & K, Ηβ, Mg I 5173 Å, C I 5380 Å, Fe I 6173 Å, Fe I 6301 Å, Ha, O I 7772 Å, and Ca II 8542 Å).Conclusions.The CLV of line profiles and continua are shared in the CDS as machine readable tables, providing a quantitative constraint on theoretical models that aim to model stellar atmospheres.