bluuebunny/crossref_metadata_2025_split huggingface dataset:
KAJIAN PERLINDUNGAN HUKUM TERHADAP SEORANG TERSANGKA SALAH TANGKAP DALAM PERSPEKTIF HUKUM ACARA PIDANA
Authors: Hartono M Rudi , Aditama Ryan 
Published: September 2022

Praktik perlindungan HAM tersirat didalam UU No. 8 Tahun 1981 tentang Kitab Undang-undang Hukum Acara Pidana (KUHAP), yang merupakan upaya untuk melindungi hak asasi manusia pelaku kejahatan sebagai individu dengan hak asasi manusia (HAM), khususnya terhadap mereka yang terlibat dalam suatu kejahatan, suatu delik. Maksud dan fungsi hukum acara pidana yang ditetapkan dalam Kitab Undang-undang Hukum Acara Pidana (KUHAP) terutama untuk melindungi warga negara dari tindakan sewenang-wenang atau perbuatan aparat penegak hukum.Namun di sisi lain, undang-undang juga memberikan kekuasaan kepada pemerintah dan negara, melalui aparat penegak hukumnya, untuk menindak warga negara yang melanggar aturan hukum, termasuk penangkapan yang tidak semestinya terhadap orang yang diduga melakukan tindak pidana. Tujuan dari penyelidikan ini adalah untuk mengetahui dan menganalisis bagaimana perlindungan hukum diberikan kepada tersangka yang ditahan secara tidak adil didasarkan KUHAP dan tindakan peradilan yang dapat dilakukan terhadap tersangka untuk kejahatan ilegal Penahanan berdasarkan KUHAP.Metode Pendekatan Penelitian digunakan Penelitian Yuridis Normatif. Metode Penelitian ini didasarkan pada prosedur penelitian ilmiah yang bertujuan untuk menemukan kebenaran berdasarkan logika ilmu hukum dari sisi normatif dengan menghubungkan dengan ketentuan peraturan perundang-undangan yang bersangkutan. Tujuan akhir Studi yang diharapkan dalam penelitian ini adalah memberikan kontribusi pemikiran hukum tentang kewenangan polisi untuk melakukan penangkapan sehingga tindakan menangkap seseorang secara melawan hukum dapat diminimalisir di kemudian hari. diduga melakukan tindak pidana tetapi tidak memiliki bukti dan fakta hukum yang cukup.
Pertanggungjawaban Pidana Terhadappelaku Tindak Pidana Mengedarkan Obat Tanpa Izin Edar
Authors: Suzanalisa Suzanalisa , Zachman Nuraini 
Published: September 2022

Obat dalam pelayanan kesehatan merupakan komponen yang sangat penting karena diperlukan dalam sebagian besar upaya kesehatan. Dewasa ini meningkatnya kesadaran dan pengetahuan masyarakat tentang kesehatan juga mendorong masyarakat menuntut pelayanan kesehatan termasuk pelayanan obat yang semakin professional sehingga diperlukan peraturan perundang undangan dalam rangka menghindari terjadinya penyalahgunaan atau penyimpangan dalam menggunakan sediaan farmasi/alat kesehatan yang dapat membahayakan masyarakat oleh pihak yang tidak bertanggung jawab, mengedarkan obat dengan melakukan penyimpangan sudah tentu obat tersebut tidak dapat digunakan dalam proses penyembuhan. Spesifikasi Penelitian dalam penelitian ini adalah Empiris Normatif. Sehingga berguna bagi para penegak hukum harus bisa lebih melihat aspek sosiologis secara mendalam dalam memberi pertanggungjawaban terhadap pelaku tindak pidana obat tanpa izin edar, yang mana tujuan dari itu semua adalah memberi efek jera.
LIMBAH KERTAS DALAM PENCIPTAAN KARYA PATUNG POTRET DIRI : SIGNIFIKASI MATERIAL DALAM SENI RUPA
Authors: Himawan M. Hendra 
Published: September 2022

Abstrak : Signifikasi material membawa implikasi yang mendalam terhadap makna simbolik, konseptual, material dan empirik sebuah karya. Sebagai konsep estetika, materialitas mendudukkan posisi penting dalam formalisme khususnya pada aspek visual murni dan minat strukturalisme perihal konteks dan komunikasi seni. Mengikuti perkembangan wacana teori kritis yang mengakui relativias kebenaran, gagasan materialitas memberikan pendekatan teori seni yang berbasis pada waktu dan situasi. Gagasan terkait materialitas karya seni telah melampaui fakta materi fisiknya. Sebentuk akumulasi informasi yang relevan terkait keberadaan fisik karya, sejarah material, pengalaman personal seniman, benturan sosial, dinamika kerja studio, kecenderungan praktik dalam arus wacana sejarah seni, yang semuanya relevan dengan pengalaman estetis. Fisik karya seni, aspek-aspek yang dapat dirasakan dan diverifikasi oleh pemirsa menjadi pertimbangan pertama seniman. Selanjutnya, fisik karya yang diwujudkan akan berdampak pada konten, lebih lanjut lagi : makna. Makalah ini menguji sejauhmana pemanfaatan limbah kertas sebagai material penciptaan karya seni bersinggungan langsung dengan praktik penciptaan artistic dan dinamika internal subjek seniman.Keywords : Limbah kertas, material, patung potret The significance of the material brings a deep meaning to the symbolic, conceptual, material and empirical meaning of a work. As an aesthetic concept, materiality occupies an important position in formalism, especially in purely visual aspects and structuralism interests date context and art communication. Following the development of critical theory discourse that recognizes the relativity of truth, the notion of materiality provides a theoretical approach based on time and situation. Plants regarding the materiality of works of art have transcended the facts of their physical material. A form of accumulation of relevant information related to the physical existence of the work, historical material, the artist's personal experience, social, studio dynamics, practice trends in art history discourse, all of which are relevant to the aesthetic experience. The physicality of the work of art, aspects that can be enjoyed and enjoyed by the viewer are the first considerations of the artist. Furthermore, the physical work that is realized will have an impact on the content, furthermore: meaning. This paper examines the extent to which the use of paper waste as an art creation material is in direct contact with the practice of creating art and the dynamics of the artist's internal subject.Keywords : paper, material, portrait sculpture
Leptospirosis una enfermedad zoonótica, breve revisión de la situación en el Ecuador
Authors: Chuva Castillo Pedro , Castillo Hidalgo Edy 
Published: September 2022

Introducción: La leptospirosis como una enfermedad de carácter zoonótico en los últimos años ha sido de gran preocupación en el mundo siendo una enfermedad de declaración ante la OMS a medida del pasar de los años en ciertas zonas preferentemente las ligadas a climas tropicales y subtropicales se ha establecido que tiene un aumento su presencia especialmente en estaciones lluviosas, esta bacteria causa enfermedad en varios pacientes sea animales o humanos, y por esa causa en importante conocer su distribución y propagación. Objetivos: El objetivo principal de la presente investigación es tener un documento actualizado sobre la leptospirosis su potencial zoonosis y el estado actual en el país Ecuador. Determinar la leptospirosis como una enfermedad zoonótica de importancia epidemiológica a nivel nacional. Conocer la distribución de la leptospirosis en cuánto a sus investigaciones a nivel nacional. Metodología: Bibliográfica para leptospirosis como enfermedad de importancia zoonótica para elaborar un documento con una actualización de esta importante, se encontraron 23 publicaciones, pero se tomaron en cuenta 13 esto con la finalidad de conocer la situación actual y real de la leptospirosis en el Ecuador. Resultados: Esta investigación se apreció que los casos positivos para leptospirosis utilizando cualquier técnica diagnostica se obtuvieron diversos resultados los cuales en promedio fue de 58.04% de prevalencia siendo la región costa la que presenta la mayoría de los casos. Conclusiones: La leptospirosis es una enfermedad que afecta a varias especies incluido al humano a nivel mundial, pero en nuestro país es sub considerada, se puede concluir que en todas las investigaciones que se reportan existe una alta prevalencia y la región más estudiada es la costa.
Análisis de la gestión de la oferta del agroturismo en la finca “Cumandá”, del cantón Milagro, Ecuador
Authors: Abarca-Aguirre Diana , Parreño-García Jorge 
Published: September 2022

La investigación tuvo como objetivo analizar la gestión de la oferta del agroturismo en la finca “Cumandá”, del cantón Milagro. El enfoque de la investigación fue cualitativo no experimental, teniendo como población involucrada de estudio a la demanda turística de dicho establecimiento. A partir de una revisión bibliográfica se determinó un histórico del desarrollo turístico del cantón Milagro, así como de sus características generales y la estructura del sistema turístico cantonal. Por otra parte, con los datos obtenidos de la revisión de la ficha técnica de la finca agroturística Cumandá, se sintetizaron las características del establecimiento y los servicios que oferta. Posteriormente, se determinaron los problemas que afectan la gestión turística del cantón Milagro aplicando una matriz de involucrados para conocer los problemas percibidos y los posibles proyectos que contribuirían a abordar la solución. Asimismo, con todos los datos recogidos anteriormente se realizó un análisis FODA que permitió establecer las estrategias con las que se propuso un plan de acción. Finalmente, la investigación demostró la potencialidad agroturística del cantón Milagro y las falencias que posee en cuanto a la gestión pública y privada, dando como resultado la estructuración de un plan de acción con base a tres estrategias que contribuyan a mejorar la gestión agroturística de la finca Cumandá.
Palabras clave: Agroturismo, desarrollo turístico, turismo rural, gestión agroturística.
Biosynthesized silver nanoparticles using Polygonatum geminiflorum efficiently control fusarium wilt disease of tomato
Authors: Ahmad Maaz , Ali Ahmad , Ullah Zahid , Sher Hassan , Dai Dong-Qin , Ali Mohammad , Iqbal Javed , Zahoor Muhammad , Ali Iftikhar 
Published: September 2022

Nanomaterials are gaining tremendous potential as emerging antimicrobials in the quest to find resistance-free alternatives of chemical pesticides. In this study, stable silver nanoparticles were synthesized using the aqueous extract of medicinal plant speciesPolygonatum geminiflorum,and their morphological features were evaluated by transmission electron microscopy, X-ray diffraction spectroscopy and energy dispersive X-ray analysis.In vitroAntifungal activity of the synthesized silver nanoparticles (AgNPs) andP. geminiflorumextract (PE) either alone or in combination (PE-AgNPs) againstFusarium oxysporumwas evaluated using disc-diffusion and well-diffusion methods.In plantaassay of the same treatments againstFusariumwilt diseases of tomato was evaluated by foliar spray method. Moreover, plant extract was evaluated for the quantitative investigation of antioxidant activity, phenolics and flavonoids by spectroscopic and HPLC techniques. Phytochemical analysis indicated the presence of total phenolic and flavonoid contents as 48.32 mg ± 1.54 mg GAE/g and 57.08 mg ± 1.36 mg QE/g, respectively. The DPPH radical scavenging of leaf extract was found to be 88.23% ± 0.87%. Besides, the HPLC phenolic profile showed the presence of 15 bioactive phenolic compounds. Characterization of nanoparticles revealed the size ranging from 8 nm to 34 nm with average crystallite size of 27 nm. The FTIR analysis revealed important functional groups that were responsible for the reduction and stabilization of AgNPs. In thein vitroassays, 100 μg/ml of AgNPs and AgNPs-PE strongly inhibitedFusarium oxysporum. The same treatments tested againstFusariumsprayed on tomato plants in controlled environment exhibited nearly 100% plant survival with no observable phytotoxicity. These finding provide a simple baseline to controlFusariumwilt using silver nano bio-control agents without affecting the crop health.
Effects of angiotensin II combined with asparaginase and dexamethasone on the femoral head in mice: A model of steroid-induced femoral head osteonecrosis
Authors: Liu Jiahe , Li Chenzhi , Yang Fan , Li Minde , Wu Baolin , Chen Haojie , Li Shaopeng , Zhang Xiuzhi , Yang Jiahui , Xia Yan , Wu Mingjian , Li Yancheng , Liu Baoyi , Zhao Dewei 
Published: September 2022

Background: To study the pathogenesis of steroid-induced femoral head osteonecrosis, an ideal animal model is very important. As experimental animals, mice are beneficial for studying the pathogenesis of disease. However, there are currently few mouse models of steroid-induced femoral head osteonecrosis, and there are many questions that require further exploration and research.Purposes: The purpose of this study was to establish a new model of osteonecrosis in mice using angiotensin II (Ang II) combined with asparaginase (ASP) and dexamethasone (DEX) and to study the effects of this drug combination on femoral head osteonecrosis in mice.Methods: Male BALB/c mice (n = 60) were randomly divided into three groups. Group A (normal control, NC) was treated with physiological saline and given a normal diet. Group B (DEX + ASP, DA) was given free access to food and water (containing 2 mg/L DEX) and subjected to intraperitoneal injection of ASP (1200 IU/kg twice/week for 8 weeks). Group C (DEX + ASP + Ang II, DAA) was treated the same as group B, it was also given free access to food and water (containing 2 mg/L DEX) and subjected to intraperitoneal injection of ASP (1200 IU/kg twice/week for 8 weeks), but in the 4th and 8th weeks, subcutaneous implantation of a capsule osmotic pump (0.28 mg/kg/day Ang II) was performed. The mice were sacrificed in the 4th and 8th weeks, and the model success rate, mouse mortality rate, body weight, blood lipids, coagulation factors, histopathology, and number of local vessels in the femoral head were evaluated.Results: DAA increased the model success rate [4th week, 30% (DA) vs. 40% (DAA) vs. 0% (NC); 8th week, 40% (DA) vs. 70% (DAA) vs. 0% (NC)]. There was no significant difference in mortality rate between the groups [4th week, 0% (DA) vs. 0% (DAA) vs. 0% (NC); 8th week, 5% (DA) vs. 10% (DAA) vs. 0% (NC)]. DAA affected mouse body weight and significantly affected blood lipids and blood coagulation factors. DAA reduces the number of blood vessels in the femoral head and destroys the local blood supply.Conclusion: Angiotensin II combined with asparaginase and dexamethasone can obviously promote the necrosis of femoral head and provide a new idea for the model and treatment of osteonecrosis.
Metabolomic profiling of exhaled breath condensate for the diagnosis of pulmonary aspergillosis
Authors: Wei Shuo , Chen Yi-sheng , Shi Yi 
Published: September 2022

ObjectiveThis study aims to ascertain the unique metabolic profile of exhaled breath condensate (EBC) samples in pulmonary aspergillosis (PA) patients, and explore their usefulness for the diagnosis of PA.MethodsA total of 133 patients were included in the study, including 66 PA patients (invasive pulmonary aspergillosis, n=3; chronic pulmonary aspergillosis, n=60; allergic bronchopulmonary aspergillosis, n=3) and controls (n=67). Ultra high-performance liquid chromatography coupled with high-resolution mass spectrometry(UHPLC-HRMS) was used to analyze EBC samples. Metabolic profiling of EBC samples that were collected from 22 CPA patients at various times during treatment (before treatment, &lt;1 month, 1–2 months, 2–3 months, 3–6 months, and ≥6 months after treatment initiation) were performed using UHPLC-HRMS. Potential biomarkers were evaluated using cluster analysis, Venn diagram and receiver operating characteristic analysis (ROC).ResultsA total of 47 metabolites of potential interest were detected in the EBC samples. Further investigation showed that Asperpyrone C, Kotanin, Terphenyllin, Terrelumamide B, and Cyclotryprostatin D could be used as a diagnostic biomarker for PA. The classification between metabolic profiling of EBC samples from PA patients and controls was good with a sensitivity of 100%, specificity 89.6% for patients with PA, respectively. Venn diagram analysis of these biomarker candidates displayed three main types of compounds, which could be used for the further discrimination of aspergilloma and chronic cavitary PA. In addition, antifungal treatment had a limited influence on the value of the EBC results.ConclusionsThis metabolomic approach using UHPLC-HRMS could be used as a noninvasive method for the diagnosis of PA.
Triglyceride-glucose index is associated with quantitative flow ratio in patients with acute ST-elevation myocardial infarction after percutaneous coronary intervention
Authors: Yu Bingyan , Mo Yuhao , Hu Xiangming , Wang Weimian , Liu Jieliang , Jin Junguo , Lun Ziheng , Luo Bu Ci Ren , Dong Haojian , Zhou Yingling 
Published: September 2022

BackgroundThe triglyceride-glucose (TyG) index is a novel marker representing the degree of insulin resistance (IR) and is closely related to cardiovascular diseases. However, the association between the TyG index and vascular function in patients with acute ST-elevation myocardial infarction (STEMI) after percutaneous coronary intervention (PCI) remains unknown.Materials and methodsThis study was a post hoc analysis of a multicenter, prospective cohort study. In this study, patients with STEMI who underwent PCI were included, and coronary angiography data were analyzed by Quantitative coronary angiography (QCA) and quantitative flow ratio (QFR). In addition, the TyG index was calculated as follows: Ln [fasting triglyceride (mg/dl) × fasting blood glucose (mg/dl) × 1/2]. According to the post-PCI QFR, patients were divided into two groups: post-PCI QFR ≤ 0.92 group and post-PCI QFR &gt; 0.92 group. Construction of logistic regression model to explore the relationship between the TyG index and post-PCI QFR.ResultsA total of 241 STEMI patients were included in this study. Compared with patients in the post-PCI QFR &gt; 0.92 group, the TyG index was higher in the post-PCI QFR ≤ 0.92 group. Logistic regression model showed that after adjusting for other confounding factors, the TyG index was positively correlated with the risk of post-PCI QFR ≤ 0.92 (OR = 1.697, 95% CI 1.171–2.460, P = 0.005). Restricted cubic splines showed the cutoff value of TyG index associated with post-PCI QFR ≤ 0.92 risk was 9.75.ConclusionThe TyG index was associated with the risk of post-PCI QFR ≤ 0.92 in STEMI patients. The risk of post-PCI QFR ≤ 0.92 increased when the TyG index exceeded 9.75.
Immune checkpoint inhibitor therapy increases systemic SDF-1, cardiac DAMPs Fibronectin-EDA, S100/Calgranulin, galectine-3, and NLRP3-MyD88-chemokine pathways
Authors: Quagliariello Vincenzo , Passariello Margherita , Di Mauro Annabella , Cipullo Ciro , Paccone Andrea , Barbieri Antonio , Palma Giuseppe , Luciano Antonio , Buccolo Simona , Bisceglia Irma , Canale Maria Laura , Gallucci Giuseppina , Inno Alessandro , De Lorenzo Claudia , Maurea Nicola 
Published: September 2022

BackgroundImmune checkpoint inhibitors (ICIs) have significantly changed the oncology clinic in recent years, improving survival expectations in cancer patients. ICI therapy have a broad spectrum of side effects from endocrinopathies to cardiovascular diseases. In this study, pro-inflammatory and pro-fibrotic effects of short-term ICIs therapy in preclinical models were analyzed.MethodsFirstly, in a human in vitro model, human cardiomyocytes co-cultured with hPBMC were exposed to ICIs (with CTLA-4 or PD-1 blocking agents, at 200 nM) for 72 h. After treatment, production of DAMPs and 12 cytokines were analyzed in the supernatant through colorimetric and enzymatic assays. C57/Bl6 mice were treated with CTLA-4 or PD-1 blocking agents (15 mg/kg) for 10 days. Before (T0), after three days (T3) and after treatments (T10), ejection fraction, fractional shortening, radial and longitudinal strain were calculated by using bidimensional echocardiography (Vevo 2100, Fujfilm). Fibrosis, necrosis, hypertrophy and vascular NF-kB expression were analyzed through Immunohistochemistry. Myocardial expression of DAMPs (S100- Calgranulin, Fibronectin and Galectine-3), MyD88, NLRP3 and twelve cytokines have been analyzed. Systemic levels of SDF-1, IL-1β, and IL-6 were analyzed before, during and after ICIs therapy.ResultsRadial and longitudinal strain were decreased after 10 days of ICIs therapy. Histological analysis of NF-kB expression shows that short-term anti-CTLA-4 or anti-PD-1 treatment increased vascular and myocardial inflammation. No myocardial hypertrophy was seen with the exception of the pembrolizumab group. Myocardial fibrosis and expression of galectin-3, pro-collagen 1-α and MMP-9 were increased after treatment with all ICIs. Both anti-CTLA-4 or anti-PD-1 treatments increased the expression of DAMPs, NLRP3 inflammasome and MyD88 and induced both in vitro and in vivo the secretion of IL-1β, TNF-α and IL-6. Systemic levels of SDF-1, IL-1β and IL-6 were increased during and after treatment with ICIs.ConclusionsShort therapy with PD-1 and CTLA-4 blocking agents increases vascular expression of NF-kB, systemic SDF-1, IL-1β, IL-6 levels and myocardial NLRP3, MyD88 and DAMPs expression in preclinical models. A pro-inflammatory cytokine storm was induced in myocardial tissues and in cultured cardiac cells after ICIs therapy. The overall picture of the study suggests new putative biomarkers of ICIs-mediated systemic and myocardial damages potentially useful in clinical cardioncology.
Association of endothelial glycocalyx shedding and coronary microcirculation assessed by an angiography-derived index of microcirculatory resistance in patients with suspected coronary artery disease
Authors: Liu Yang , Chen Si , Liu Shaoyan , Sun Guoqiang , Sun Zhijun , Liu Hongbin 
Published: September 2022

BackgroundThe endothelial glycocalyx (EG) is essential for maintaining microvascular homeostasis. However, the relationship between the EG and coronary microcirculation remains to be elucidated. One of the main components of EG is syndecan-1, and its shedding has been claimed to represent the state of the EG. In this study, we aimed to analyze the association between syndecan-1 and the coronary microcirculation.MethodsWe enrolled suspected coronary artery disease (CAD) patients who consecutively underwent coronary angiography (CAG) and angiography-based analysis of physiological indices in the left anterior descending artery (LAD). Serum syndecan-1 was measured by enzyme-linked immunosorbent assay (ELISA). The coronary microcirculation was evaluated by the presence of coronary microvascular dysfunction (CMD) and an impaired microvascular vasodilatory capacity (IMVC), which were quantified by an angiography-derived index of microcirculatory resistance (IMRangio) in the maximum hyperemic state (H-IMRangio) induced by adenosine triphosphate and the ratio (RRRangio) of IMRangio in the non-hyperemic phase to H-IMRangio, respectively.ResultsA total of 528 patients were enrolled in this study. There was no difference in epicardial coronary complexity between patients with high syndecan-1 (HSG) and low syndecan-1 (LSG) levels grouped by the median concentration of syndecan-1 (SYNTAX: 7[3, 10] vs. 9[4, 12], P = 0.15). However, H-IMRangio and RRRangio were different between the LSG and HSG groups (H-IMRangio: 23.64 ± 6.28 vs. 27.67 ± 5.59, P &lt; 0.01; RRRangio: 1.74[1.46, 2.08] vs. 1.55[1.34, 1.72], P &lt; 0.01). Patients with CMD (H-IMRangio &gt; 25) and patients with IMVC (RRRangio below the median value) both had higher syndecan-1 levels (CMD: 86.44 ± 54.15 vs. 55.2 ± 43.72, P &lt; 0.01; IMVC: 83.86 ± 55.41 vs. 59.68 ± 45.06, P &lt; 0.01). After adjustment for confounding factors, HSG remained associated with the presence of CMD and IMVC (CMD: odds ratio [OR]: 2.769, P &lt; 0.01; IMVC: OR: 1.908, P &lt; 0.01).ConclusionHigh levels of syndecan-1 are independently associated with the presence of CMD and IMVC among patients with suspected CAD.