bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mix-Tool: An Edge-of-Field Approach to Predict Pesticide Mixtures of Concern in Surface Water From Agricultural Crops
Authors: Finizio Antonio , Di Guardo Andrea , Menaballi Luca , Barra Caracciolo Anna , Grenni Paola 
Published: May 2022

Abstract
Current regulation on the authorization of plant protection products (PPPs) in the European Union is limited to the evaluation of ecological risks for the single active substances they contain. However, plant protection treatments in agriculture often consist of PPPs already containing more than one active substance; moreover, each cropped field receives multiple applications per year, leading to complex pesticide mixtures in the environment. Different transport processes lead to a multitude of heterogeneous and potentially toxic substances that, for example, may reach water bodies and act simultaneously on natural freshwater ecosystems. In this context, the development of methodologies and tools to manage risks of pesticides mixtures is imperative to improve the current ecological risk assessment procedures and to avoid further deterioration of ecological quality of natural resources. The present study suggests new procedures for identifying pesticide mixtures of potential concern released from agricultural crops in surface water. The approach follows the European Union regulatory context for the authorization of PPPs in the market (edge-of field risk assessment) and requires the use of Forum for the Co-ordination of pesticide fate models and their Use (FOCUS) models (Step 3 and 4) for calculating the concentrations in surface water of mixture components on a daily basis. Moreover, it uses concentration addition models to calculate the toxic potency of the pesticide mixtures released by a treated crop. To implement this procedure, we developed a simple Microsoft-Excel-based tool. We also considered two case studies (maize and apple tree), representative of Italian agricultural scenarios for annual and perennial crops. Moreover, we compared results with 3 years of monitoring data of surface water bodies of the Lombardia region (northern Italy) where the two crops are largely present. Environ Toxicol Chem 2022;41:2028–2038. © 2022 The Authors. Environmental Toxicology and Chemistry published by Wiley Periodicals LLC on behalf of SETAC.
Queer Theory from Elsewhere and the Im/Proper Objects of Queer Anthropology
Authors: Weiss Margot 
Published: May 2022

AbstractWhat is queer in contemporary transnational queer studies? In this essay, I explore queer as a political‐intellectual orientation and aspirational field animated by its constitutive polarity: between a more constrained queer focused on sex, sexuality, and gender and a more expansive queer that bears an oblique relationship to these more proper objects. I trace how the desire to do justice to our objects of study produces queer’s characteristic inversions, so that when we seek to move “beyond” queer’s proper objects, we find ourselves drawn back into them and inversely, when we seek to center proper subjects of queer, we find ourselves elsewhere and otherwise. I illuminate this queer movement through a conceptual review of recent scholarship in queer anthropology (loosely 2015‐21), drawing out queer as (1) a challenge to categorical legibility, (2) a way to rethink vitalities between bio‐ and necropolitics, (3) a field of political, social, and sensual erotics and desires, and (4) a deconstruction of normative knowledge projects and epistemologies. Throughout, I reflect on anthropology's place in a larger project of a queer theory from (and seeking) an elsewhere.
Predictors of the change in burden, strain, mood, and quality of life among caregivers of Parkinson's disease patients
Authors: Santos‐García Diego , de Deus Fonticoba Teresa , Cores Bartolomé Carlos , Íñiguez Alvarado Maria Cristina , Feal Panceiras Maria J. , Suárez Castro Ester , Canfield Héctor , Martínez Miró Cristina , Jesús Silvia , Aguilar Miquel , Pastor Pau , Planellas Lluís , Cosgaya Marina , García Caldentey Juan , Caballol Nuria , Legarda Ines , Hernández Vara Jorge , Cabo Iria , López Manzanares Lydia , González Aramburu Isabel , Ávila Rivera Maria A. , Gómez Mayordomo Víctor , Nogueira Víctor , Puente Víctor , Dotor García‐Soto Julio , Borrué Carmen , Solano Vila Berta , Álvarez Sauco María , Vela Lydia , Escalante Sonia , Cubo Esther , Carrillo Padilla Francisco , Martínez Castrillo Juan C. , Sánchez Alonso Pilar , Alonso Losada Maria G. , Ariztegui Nuria López , Gastón Itziar , Kulisevsky Jaime , Blázquez Estrada Marta , Seijo Manuel , Martínez Javier Rúiz , Valero Caridad , Kurtis Mónica , de Fábregues Oriol , González Ardura Jessica , Alonso Redondo Ruben , Ordás Carlos , López DíazL Luis M. , McAfee Darrian , Martinez‐Martin Pablo , Mir Pablo ,   COPPADIS Study Group
Published: May 2022

AbstractBackground and ObjectiveCaregiver burden in Parkinson's disease (PD) has been studied in many cross‐sectional studies but poorly in longitudinal ones. The aim of the present study was to analyze the change in burden, strain, mood, and quality of life (QoL) after a 2‐year follow‐up in a cohort of caregivers of patients with PD and also to identify predictors of these changes.Patients and MethodsPD patients and their caregivers who were recruited from January/2016 to November/2017 from 35 centers of Spain from the COPPADIS cohort were included in the study. They were evaluated again at 2‐year follow‐up. Caregivers completed the Zarit Caregiver Burden Inventory (ZCBI), Caregiver Strain Index (CSI), Beck Depression Inventory‐II (BDI‐II), and EUROHIS‐QOL 8‐item index (EUROHIS‐QOL8) at baseline (V0) and at 2‐year follow‐up (V2). General linear model repeated measure and lineal regression models were applied.ResultsSignificant changes, indicating an impairment, were detected on the total score of the ZCBI (p < 0.0001), CSI (p < 0.0001), BDI‐II (p = 0.024), and EUROHIS‐QOL8 (p = 0.002) in 192 PD caregivers (58.82 ± 11.71 years old; 69.3% were females). Mood impairment (BDI‐II; β = 0.652; p < 0.0001) in patients from V0 to V2 was the strongest factor associated with caregiver's mood impairment after the 2‐year follow‐up. Caregiver's mood impairment was the strongest factor associated with an increase from V0 to V2 on the total score of the ZCBI (β = 0.416; p < 0.0001), CSI (β = 0.277; p = 0.001), and EUROHIS‐QOL (β = 0.397; p = 0.002).ConclusionBurden, strain, mood, and QoL were impaired in caregivers of PD patients after a 2‐year follow‐up. Mood changes in both the patient and the caregiver are key aspects related to caregiver burden increase.
Combination of tofogliflozin and pioglitazone for NAFLD: Extension to the ToPiND randomized controlled trial
Authors: Yoneda Masato , Kobayashi Takashi , Honda Yasushi , Ogawa Yuji , Kessoku Takaomi , Imajo Kento , Nogami Asako , Taguri Masataka , Kirikoshi Hiroyuki , Saito Satoru , Nakajima Atsushi 
Published: May 2022

Abstract
The incidence of nonalcoholic fatty liver disease (NAFLD) has recently increased and is related to obesity and the associated surge in type 2 diabetes mellitus (T2DM) and metabolic syndromes. This trial follows up on our previous work and forms part of the ToPiND study. We aimed to combine tofogliflozin and pioglitazone treatment for hepatic steatosis in patients with NAFLD and T2DM. In this open‐label, prospective, single‐center, randomized clinical trial, patients with NAFLD with T2DM and a hepatic fat fraction of ≥10% were assessed based on magnetic resonance imaging proton density fat fraction. Eligible patients received either 20 mg tofogliflozin or 15–30 mg pioglitazone orally, once daily for 24 weeks, followed by combination therapy with both medicines for an additional 24 weeks. The effects on diabetes mellitus and hepatic steatosis were examined at baseline and after the completion of monotherapy and combination therapy. Thirty‐two eligible patients received the combination therapy of tofogliflozin and pioglitazone. The combination therapy showed additional improvement in glycated hemoglobin compared with each monotherapy group and showed improvement in steatosis, hepatic stiffness, and alanine aminotransferase levels compared with the tofogliflozin monotherapy group. Pioglitazone monotherapy–mediated increase in body weight decreased following concomitant use of tofogliflozin. The combination therapy resulted in lower triglyceride, higher high‐density lipoprotein cholesterol, higher adiponectin, and higher ketone body levels. Conclusion: In addition to the additive effects of tofogliflozin and pioglitazone in patients with T2DM and NAFLD, combination therapy was suggested to reduce weight gain and induce cardioprotective effect. Further studies with more patients are needed to investigate the combination therapy of various drugs.
Thermal characteristics of hydrated salt blended with Tio2 for thermal energy storage
Authors: Singh Varun Kumar , Kumar Devesh , Sanjay  
Published: May 2022

AbstractDevelopment leads to an increment in the demand for energy. Conventional sources of energy are fulfilling our energy demands but they are crossing environmental barriers resulting in adverse climatic change. Renewable source of energy is becoming popular as a solution to the energy crisis. To reduce the gap between energy demand and supply, energy storage methods should be developed more. In this paper, performance improvement of phase change material for energy storage purposes has been investigated. NaNO3/KNO3, which is a salt hydrate, is used as a phase change material. The weight proportion of NaNO3 and KNO3 is 55% and 45%, respectively. TiO2 is used as an additive for performance improvement of phase change material in nanoparticle form with different particle sizes of 10, 20, and 30 nm. All the abovementioned nanoparticles were blended with phase change material (PCM) to make three different samples for testing. The weight percentage of TiO2 is constant in every sample, which is 5%. Specific heat, thermal conductivity, charging, and discharging of PCM have been measured for different particle sizes along with the effects of temperature variation on the abovementioned properties. Specific heat has shown an increment by 16%, 20.5%, and 23.6%, and thermal conductivity has shown a decrement by 13%, 16.5%, and 21.5% for 10, 20, and 30 nm particle sizes, respectively. Blending with TiO2 has increased the rate of heating and decreased the rate of cooling of phase change material.
Performance of HPV E6/E7 mRNA assay as primary screening test: Results from the NTCC2 trial
Authors: Giorgi Rossi Paolo , Ronco Guglielmo , Mancuso Pamela , Carozzi Francesca , Allia Elena , Bisanzi Simonetta , Gillio‐Tos Anna , De Marco Laura , Rizzolo Raffaella , Gustinucci Daniela , Del Mistro Annarosa , Frayle Helena , Confortini Massimo , Iossa Anna , Cesarini Elena , Bulletti Simonetta , Passamonti Basilio , Gori Silvia , Toniolo Laura , Barca Alessandra , Bonvicini Laura , Venturelli Francesco , Benevolo Maria ,   NTCC2 Working Group
Published: May 2022

AbstractAs the primary screening test, E6/E7 mRNA has shown similar sensitivity for CIN3+ and lower positivity rate than the HPV DNA test. Nevertheless, the overall mRNA positivity is too high for immediate colposcopy, making a triage test necessary. The aim was to estimate the mRNA performance as a primary test with different triage strategies. All HPV DNA‐positives were tested for mRNA, cytology and p16/ki67. A sample of HPV DNA‐negatives was also tested for mRNA to estimate test specificity. We included all CIN3+ histologically diagnosed within 24 months since recruitment. Of the 41 127 participants, 7.7% were HPV DNA‐positive, of which 66.4% were mRNA‐positive. Among the HPV DNA‐negatives, 10/1108 (0.9%) were mRNA‐positive. Overall, 97 CIN3+ were found. If mRNA was used as the primary test, it would miss about 3% of all CIN3+ with a 22% reduction of positivity compared with HPV DNA. The weighted specificity estimate for <CIN2 was 94.5% (95% CI = 93.9%‐94.9%) and sensitivity for CIN3+ was 96.9% (95% CI = 91.3%‐99.1%). If all the weighted estimated 6.0% mRNA‐positive women had been referred to colposcopy, PPV for CIN3+ would have been 4.2%. Cytology or p16/ki67 triage would decrease immediate referral to 1.7% and 2.0%, increasing PPV to 11.2% and 11.7%, respectively; total colposcopy referral would be 4.0% and 3.9%, respectively. As the primary screening test, the mRNA assay showed a positivity rate lower than that of HPV DNA, with a small number of CIN3+ missed. Triage with cytology or p16/ki67 would only marginally decrease overall colposcopy referral.
At the feet of storytellers: Implications for practicing early relational health conversations
Authors: Charlot‐Swilley Dominique , Condon Marie‐Celeste , Rahman Tininka 
Published: May 2022

AbstractA family‐ and culturally‐centered approach to conversations about early relational health (ERH) can open up opportunities for universal family engagement. The appraisal of family‐baby relational health is more trustworthy and useful when there is attunement to family voice and facilitator bias. Early Relational Health Conversations (ERH‐C) is a model for ERH promotion and intervention. This model has eight components: preparing and entering the ERH‐C space, accessing strength and knowledge in a healing‐centered space, pausing and co‐creating, storytelling, witnessing, mutual reflection, affirming, and claiming their relationship narrative, and mutual insight. It is a paradigm shift in working with African American families and possibly other historically marginalized families who are also impacted by structural racism. The eight components are explained, and examples are given from the perspective of an Africentric worldview. The importance of cultural humility, attuning to and honoring family culture is emphasized. Insights for implementation in primary care and other settings are provided. Healing‐centered engagement practices embedded in ERH‐C have the potential to move ERH work into the social justice arena. The ERH‐C is a family reflection model. Ideas for future directions for ERH‐C are discussed.
Early relational health – A promising approach for equitable systems change in pediatrics: A commentary
Authors: Thomas Kandace 
Published: May 2022

AbstractPediatric primary care plays a critical role in supporting the healthy development of young children. Wisdom and research suggest that every developmental domain is shaped by the quality of close relationships, particularly the caregiver‐child relationship. Therefore, pediatric primary care has a unique opportunity to support and nurture early relationships using the Early Relational Health (ERH) framework and its applications Early Relational Health Screen, and Early Relational Health Conversations. ERH and its applications recognize years of innovation focused on the promotion of the wellbeing of caregiver‐child relationships, and children's long‐term development. Central to enhancing and elevating pediatric practice is intentional effort in using diversity‐informed, anti‐racist, equitable systems of care frameworks. This Commentary offers a call to action for pediatric primary care to create more equitable and inclusive practice via ERH. The call to action includes deepening self and institutional awareness; allocating resources for systems change, including infusing greater equity into departmental structures; and, building authentic relationships with patients, families, and communities. This will result in intentional systems change centered on equitable practice.
Depressive symptoms among people living with HIV in permanent supportive housing: Findings from a community‐based participatory study in Vancouver, Canada
Authors: Vorobyova Anna , Braley McKenzie S. , Burgess Heather , Grieve Sean , Lyndon Sharyle , Wesseling Tim , Parashar Surita 
Published: May 2022

AbstractPermanent supportive housing (PSH) is an intervention addressing housing needs among marginally housed individuals. Little is known about whether and how PSH influences depressive symptoms among people living with HIV (PLHIV). This article shares results from a community‐based study that, in 2016–2017, interviewed 24 residents of a PSH facility designated for PLHIV in Vancouver, Canada. The themes of taking control; social connectedness; conviviality; and relationships and supports described how the PSH environment affected depressive symptoms among the residents.
Modulation of IKs channel–PIP2 interaction by PRMT1 plays a critical role in the control of cardiac repolarization
Authors: An Xue , Lee Jiwon , Kim Ga Hye , Kim Hyun‐Ji , Pyo Hyun‐Jeong , Kwon Ilmin , Cho Hana 
Published: May 2022

AbstractRecent studies have shown that protein arginine methyltransferase 1 (PRMT1) is highly expressed in the human heart, and loss of PRMT1 contributes to cardiac remodeling in the heart failure. However, the functional importance of PRMT1 in cardiac ion channels remains uncertain. The slow activating delayed rectifier K+ (IKs) channel is a cardiac K+ channel composed of KCNQ1 and KCNE1 subunits and is a new therapeutic target for treating lethal arrhythmias in many cardiac pathologies, especially heart failure. Here, we demonstrate that PRMT1 is a critical regulator of the IKs channel and cardiac rhythm. In the guinea pig ventricular myocytes, treatment with furamidine, a PRMT1‐specific inhibitor, prolonged the action potential duration (APD). We further show that this APD prolongation was attributable to IKs reduction. In HEK293T cells expressing human KCNQ1 and KCNE1, inhibiting PRMT1 via furamidine reduced IKs and concurrently decreased the arginine methylation of KCNQ1, a pore‐forming α‐subunit. Evidence presented here indicates that furamidine decreased IKs mainly by lowering the affinity of IKs channels for the membrane phospholipid, phosphatidylinositol 4,5‐bisphosphate (PIP2), which is crucial for pore opening. Finally, applying exogenous PIP2 to cardiomyocytes prevented the furamidine‐induced IKs reduction and APD prolongation. Taken together, these results indicate that PRMT1 positively regulated IKs activity through channel–PIP2 interaction, thereby restricting excessive cardiac action potential.
TGFBR2 is a novel substrate and indirect transcription target of deubiquitylase USP9X in granulosa cells
Authors: Yang Liu , Wang Siqi , Pan Zengxiang , Du Xing , Li Qifa 
Published: May 2022

AbstractThe ubiquitin‐specific peptidase 9 X‐linked (USP9X) is one of the highly conserved members belonging to the ubiquitin‐specific proteases (USPs) family, which has been reported to control substrates‐mediated biological functions through deubiquitinating and stabilizing substrates. Here, we have found that TGFBR2, the type II receptor of the transforming growth factor beta (TGF‐β) signaling pathway, is a novel substrate and indirect transcription target of deubiquitylase USP9X in granulosa cells (GCs). Mechanically, USP9X positively influences the expression of TGFBR2 at different levels through two independent ways: (i) directly targets and deubiquitinates TGFBR2, which maintains the protein stability of TGFBR2 through avoiding degradation mediated by ubiquitin‐proteasome system; (ii) indirectly maintains TGFBR2 messenger RNA (mRNA) expression via SMAD4/miR‐143 axis. Specifically, SMAD4, another substrate of USP9X, acts as a transcription factor and suppresses miR‐143 which inhibits the mRNA level of TGFBR2 by directly binding to its 3′‐untranslated region. Functionally, the maintenance of TGFBR2 by USP9X activates the TGF‐β signaling pathway, which further represses GC apoptosis. Our study highlights a functional micro‐regulatory network composed of deubiquitinase (USP9X), small noncoding RNA (miR‐143) and the TGF‐β signaling pathway, which plays a crucial role in the regulation of GC apoptosis and female fertility.
Severe electrolyte derangements from lysozymuria in acute myeloid leukemia
Authors: Pérez‐Pinzón Juliana , Olin Rebecca L. , Banerjee Rahul 
Published: May 2022

AbstractRenal dysfunction in patients with acute myeloid leukemia (AML) can be multifactorial. We present the case of a 72‐year‐old male with relapsed myelomonocytic AML who presented with transient acute kidney injury (AKI) and severe persistent electrolyte derangements. In the setting of nephrotic‐range proteinuria and electrolyte wasting without significant albuminuria or glucosuria, a diagnosis of lysozymuria was made. Lysozymuria is a rare paraneoplastic complication of AML and chronic myelomonocytic leukemia characterized by lysozyme. This represents the first case of lysozymuria presenting primarily with refractory electrolyte derangements rather than severe AKI. Lysozymuria portends a poor clinical prognosis even with aggressive management.
A subdomain model for armature reaction field and open‐circuit field prediction in consequent pole permanent magnet machines
Authors: Abbas Ahmed , Iqbal Atif 
Published: May 2022

AbstractIn this paper, the machine quantity, such as electromagnetic torque, self and mutual inductances, and electromotive force, is analytically calculated for non‐overlapping winding consequent pole slotted machine for open‐circuit field and armature reaction. The sub‐domain approach of (2‐D) analytical model is developed using Maxwell's equations and divide the problem into slots, slot‐openings, airgap and magnets region, the magnet flux‐density is calculated and analyzed for both permanent magnet (PM) and armature current reaction (AR) with radial magnetization pattern. The magnetization surface currents (MSCs) are considered at the borders of iron‐pole magnets and the value of MSCs is accurately computed. The result obtained using proposed model compared with that of FEM, (2‐D) analytical model required less computation time and achieve higher accuracy of AR and PM.
Projections of precipitation extremes based on bias‐corrected Coupled Model Intercomparison Project phase 6 models ensemble over southern Africa
Authors: Lim Kam Sian Kenny Thiam Choy , Hagan Daniel Fiifi Tawia , Ayugi Brian Odhiambo , Nooni Isaac Kwesi , Ullah Waheed , Babaousmail Hassen , Ongoma Victor 
Published: May 2022

AbstractThe increasing awareness of climate change requires accurate, reliable and timely information on possible precipitation (PRE) changes to build climate resilience. This study uses the Coupled Model Intercomparison Project phase 6 (CMIP6) data to examine the effectiveness of bias correction on simulated historical mean and extreme PRE, and investigates the projected changes in extreme PRE events over southern Africa (SAF). Quantile mapping on a gamma distribution bias correction method is applied to the historical and projected CMIP6 data, with the Global Precipitation Climatology Centre (GPCC) PRE dataset as reference data. The projection analyses are conducted for the wet (December–March) and dry (May–October) seasons for two shared socioeconomic pathway (SSP) scenarios: SSP2‐4.5 and SSP5‐8.5. The results affirm that the bias correction significantly reduces (by more than 90%) the biases in the modelled mean and extreme PRE. The projected extreme PRE shows a general drying pattern over SAF. In the wet season, wet days (R1mm) are projected to decrease by 1 and 2 days by the end of the 21st century for SSP2‐4.5 and SSP5‐8.5, respectively, while very heavy PRE days (R20mm) show a slight upward pattern over SAF, reaching 0.1 and 0.4 days for the two scenarios. In contrast, the dry season exhibits a more pronounced drying tendency, with a consistent decrease in R1mm of 2 and 0.1 days by 2100 for SSP2‐4.5 and SSP5‐8.5, respectively. R20mm is projected to decrease by 4 and 0.2 days for SSP2‐4.5 and SSP5‐8.5, respectively. This implies that SAF is expected to get drier during the dry season while the PRE intensity during the wet season is projected to increase.