bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Effect of Vitamin D Supplementation in Children With Asthma: A Meta-Analysis
Authors: Hao Meiqi , Xu Ruoxin , Luo Nachuan , Liu Miaowen , Xie Junping , Zhang Wenxiong 
Published: June 2022

BackgroundAn increasing number of studies have suggested that vitamin D can be used to treat childhood asthma, but its clinical effects are still unclear. We conducted this meta-analysis to examine the latest estimates of the effectiveness and safety of using vitamin D to treat childhood asthma.MethodsThe PubMed, The Cochrane Library, ScienceDirect, Embase, Scopus, Ovid MEDLINE, Web of Science, and Google Scholar databases were searched for randomized controlled trials (RCTs) describing vitamin D supplementation interventions for asthmatic children. Asthma exacerbation, vitamin D levels, the predicted percentage of forced expiratory volume in the first second (FEV1%) and adverse effects (AEs) were analyzed as the main outcome measures.ResultsAfter screening, eight RCTs with 738 children were included. Compared with placebos, vitamin D supplementation had a stronger effect on serum vitamin D levels [mean difference (MD) = 13.51 (4.24, 22.79), p = 0.004]. The pooled results indicated that no significant changes were found between the groups in asthma control, as measured by adopting the following indicators: asthma exacerbation [risk ratio (RR) = 0.92 (0.68, 1.25), p = 0.60]; Childhood Asthma Control Test (CACT) scores [MD = 0.15 (−0.43, 0.74), p = 0.61]; hospitalizations for asthma exacerbation [RR = 1.20 (0.48, 2.96), p = 0.70]; acute care visits [RR = 1.13 (0.77, 1.65), p = 0.63]; steroid use [RR = 1.03 (0.41, 2.57), p = 0.95]; and fractional exhaled nitric oxide (FeNO) [MD =-3.95 (−22.87, 14.97), p = 0.68]. However, vitamin D supplementation might reduce the FEV1% [MD = −4.77 (−9.35, −0.19), p = 0.04] and the percentage of predicted forced vital capacity (FVC%) [MD =-5.01 (−9.99, −0.02), p = 0.05] in patients. Subgroup analysis revealed no difference in AEs between the two groups.ConclusionsVitamin D supplementation significantly increased patients' serum vitamin D levels, but it had no benefit for asthma control. However, vitamin D supplementation might reduce patients' lung function. It is essential to systemically search for more large-scale, rigorous, and well-designed RCTs to fully confirm these conclusions.Systematic Review Registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42021288838, PROSPERO CRD42021288838.
Traditional Uses of Animals in the Himalayan Region of Azad Jammu and Kashmir
Authors: Faiz Maryam , Altaf Muhammad , Umair Muhammad , Almarry Khalid S. , Elbadawi Yahya B. , Abbasi Arshad Mehmood 
Published: June 2022

Background:The use of animals and animal-derived products in ethnopharmacological applications is an ancient human practice that continues in many regions today. The local people of the Himalayan region harbor rich traditional knowledge used to treat a variety of human ailments. The present study was intended with the aim of examining animal-based traditional medicine utilized by the population of the Himalayan region of Azad Jammu and Kashmir.Methods:Data were collected from 2017 to 2019 through individual and group interviews. Data on traditional uses of animal products were analyzed, utilizing following indices such as the frequency of citation, use value, relative importance, similarity index, principal component analysis, and cluster analysis to find the highly preferred species in the area.Results:Ethnomedicinal uses of 62 species of vertebrates and invertebrates were documented. Flesh, fat, bone, whole body, milk, skin, egg, head, feathers, bile, blood, and honey were all used in these applications. The uses of 25 animals are reported here for the first time from the study area (mainly insects and birds, including iconic species like the kalij pheasant,Lophura leucomelanos; Himalayan monal,L. impejanus; and western tragopon,Tragopan melanocephalus). The diversity and range of animal-based medicines utilized in these communities are indications of their strong connections with local ecosystems.Conclusion:Our results provide baseline data valuable for the conservation of vertebrate and invertebrate diversity in the region of Himalayan of Azad Jammu and Kashmir. It is possible that screening this fauna for medicinally active chemicals could contribute to the development of new animal-based drugs.
New Enclosure for in vivo Medical Imaging of Zebrafish With Vital Signs Monitoring
Authors: Magalhães A. C. M. , Correia P. M. M. , Oliveira R. G. , Encarnação P. M. C. C. , Domingues I. , Veloso J. F. C. A. , Silva A. L. M. 
Published: June 2022

Lately, the use of zebrafish has gained increased interest in the scientific community as an animal model in preclinical research. However, there is a lack of in vivo imaging tools that ensure animal welfare during acquisition procedures. The use of functional imaging techniques, like Positron Emission Tomography (PET), in zebrafish is limited since it requires the animal to be alive, representing a higher instrumentation complexity when compared to morphological imaging systems. In the present work, a new zebrafish enclosure was developed to acquire in vivo images while monitoring the animal’s welfare through its heartbeat. The temperature, dissolved oxygen, and pH range in a closed aquatic environment were tested to ensure that the conditions stay suitable for animal welfare during image acquisitions. The developed system, based on an enclosure with a bed and heartbeat sensors, was tested under controlled conditions in anesthetized fishes. Since the anesthetized zebrafish do not affect the water quality over time, there is no need to incorporate water circulation for the expected time of PET exams (about 30 min). The range of values obtained for the zebrafish heart rate was 88–127 bpm. The developed system has shown promising results regarding the zebrafish’s heart rate while keeping the fish still during the long imaging exams. The zebrafish enclosure ensures the animal’s well-being during the acquisition of in vivo images in different modalities (PET, Computer Tomography, Magnetic Resonance Imaging), contributing substantially to the preclinical research.
Mother-Child Social Cognition Among Multicultural Families in South Korea
Authors: Lee Joohee , Choi Kee-Hong 
Published: June 2022

ObjectiveDespite the rapidly growing number of multicultural families in South Korea, factors influencing parenting and mother-child interactions have not been well-understood. To our knowledge, the present study is the first to have examined how maternal social-cognitive capacity is associated with children's social cognition (e.g., theory of mind and emotion recognition) among multicultural families dwelling in South Korea.MethodsForty-seven multicultural mother-child dyads were recruited. The comprehensive measures on social cognition were administered to both the mothers and children, and social functioning and emotion regulation were administered to the children.ResultsA series of hierarchical regressions indicated that mothers' social cognition significantly explained children's ability to recognize static and dynamic emotional expressions, accounting for 27 and 34% of the variance, respectively. Furthermore, mothers' social cognition was significantly correlated to children's social functioning and emotion regulation. However, mothers' social cognition and children's theory of mind were non-significantly related.DiscussionThe current study examined the effects of social cognition of immigrant mothers on their children's socio-emotional development. As the findings indicated an important role of maternal factors (i.e., social cognition) for children's social cognition and their functions, psycho-social approaches (e.g., social cognition parenting education and training) should be incorporated in services for multicultural families.
Mapping Knowledge Structure and Global Research Trends in Gout: A Bibliometric Analysis From 2001 to 2021
Authors: Wen Pengfei , Luo Pan , Zhang Binfei , Zhang Yumin 
Published: June 2022

BackgroundThe incidence and prevalence of gout have been steadily increasing globally, which has resulted in gout research attracting consistently increased attention. This study aimed to visualize the knowledge structure and research trends in gout research through bibliometrics to help understand the future development of basic and clinical research.MethodsArticles and reviews on gout from 2001 to 2021 were extracted from the Web of Science Core Collection database. CiteSpace and VOSviewer software were used to visualize the knowledge network of countries, institutions, authors, references, and keywords in this field. SPSS and Microsoft Excel software were used for curve fitting and correlation analysis.ResultsA total of 3,259 articles and reviews were included. The number of publications about gout significantly increased yearly. Publications were mainly concentrated in North America, Europe, Oceania, and East Asia. The USA contributed most with 1,025 publications, followed by China and New Zealand. After adjusting for publications by population size and Gross Domestic Product (GDP), New Zealand ranked in the first place. GDP and international collaboration were significantly correlated with scientific productivity for gout research. University of Auckland and Professor Dalbeth Nicola were the most prolific institutions and influential authors, respectively. Rheumatology was the most productive journal for gout research. Gout research hotspots have shifted over time in the following order: clinical features, pathological mechanisms, complications, gouty arthritis, epidemiology, and dual-energy computed tomography to drug clinical trials, which can be observed from the keyword analysis and co-cited reference cluster analysis.ConclusionsThis study found that research on gout is flourishing. The development and experimentation of drugs for the prevention and treatment of gouty arthritis would be the focus of current research and developmental trends in future research.
Autonomous Crosslink Radionavigation for a Lunar CubeSat Mission
Authors: Turan Erdem , Speretta Stefano , Gill Eberhard 
Published: June 2022

This study presents an autonomous orbit determination system based on crosslink radiometric measurements applied to a future lunar CubeSat mission to clearly highlight its advantages with respect to existing ground-based navigation strategies. This work is based on the Linked Autonomous Interplanetary Satellite Orbit Navigation (LiAISON) method which provides an autonomous navigation solution solely using satellite-to-satellite measurements, such as range and/or range-rate, to estimate absolute spacecraft states when at least one of the involved spacecraft has an orbit with a unique size, shape, and orientation. The lunar vicinity is a perfect candidate for this type of application due to the asymmetrical gravity field: the selected lunar mission, an Earth-Moon L2(EML2) Halo orbiter, has an inter-satellite link between a lunar elliptical frozen orbiter. Simulation results show that, even in case of high-measurement errors (in the order of 100 m, 1σ), the navigation filter estimates the true states of spacecraft at EML2 with an error in the order of 500 m for position, and 2 mm/s for velocity, respectively and the elliptical lunar frozen orbiter states can be estimated in the order of 100 m for position and 1 cm/s for velocity, respectively. This study shows that range-only measurements provide better state estimation than range-rate-only measurements for this specific situation. Different bias handling strategies are also investigated. It has been found that even a less accurate ranging method, such as data-aided ranging, provides a sufficient orbit determination solution. This would simplify the communication system design for the selected CubeSat mission. The most observable states are found to be position states of the lunar orbiter via the observability analysis. In addition, the best tracking windows are also investigated for the selected mission scenario.
Prognostic Nutritional Index in Hepatocellular Carcinoma Patients With Hepatitis B Following US-Guided Percutaneous Microwave Ablation: A Retrospective Study With 1,047 Patients
Authors: Wang Yaxi , Li Xin , Yu Jie , Cheng ZhiGang , Hou Qidi , Liang Ping 
Published: June 2022

ObjectiveSeveral studies have revealed that the prognostic nutritional index (PNI) was associated with survival in several cancers. However, the prognostic value of PNI in hepatocellular carcinoma (HCC) patients following ultrasound-guided percutaneous microwave ablation (US-PMWA) remains unknown, especially in patients with hepatitis B virus (HBV) infection. Therefore, the present study aimed to evaluate the potential prognostic value of PNI in these patients.MaterialsThe medical records of 1,047 HCC patients with HBV infection following US-PMWA were retrospectively reviewed. The association between preoperative PNI and overall survival (OS), as well as other clinical characteristics of HCC, were analyzed using the Kaplan–Meier plot, log-rank test, multi-parameter Cox proportional hazards model, restricted cubic spline (RCS), and time-dependent receiver operating characteristic (ROC) curve analyses.ResultsPatients with a preoperative PNI more than 45 were verified to have better OS than patients with a PNI less than 45. In the multi-parameter Cox proportional hazards models, the log-transformed PNI was verified as an independent prognostic factor for OS. The result of the RCS analysis revealed that there was a nearly linear relationship between PNI and OS. The area under the time-dependent ROC curve for PNI in predicting OS was 0.56, which is relatively stable.ConclusionPreoperative PNI represents a convenient, noninvasive, and independent prognostic indicator in HCC patients with HBV infection following US-PMWA.
Entomopathogenic Fungi Infecting Lepidopteran Larvae: A Case from Central Argentina
Authors: Gielen Robin , Robledo Gerardo , Zapata Adriana Inés , Tammaru Toomas , Põldmaa Kadri 
Published: June 2022

Immature stages of insects are vulnerable to various antagonists, including pathogens. While the abiotic factors affecting pathogen prevalence in insect populations are reasonably well documented, much less is known about relevant ecological interactions. We studied the probability of the larvae of three lepidopteran species to die from fungal infection as a function of insect species and food plants in central Argentina. Local free-growing food plants were used to feed the lepidopteran larvae. The prevalence of entomopathogenic fungi remained low (about 5%), which is a value well consistent with observations on similar systems in other regions. Eight fungal species recorded, primarily belonging to Fusarium and Aspergillus, add evidence to the reconsideration of the nutritional modes in these genera in distinguishing the role of some species (complexes) to cause insect infections. Food plant species were found to have a substantial effect on the prevalence of entomopathogenic fungi. This was especially clear for the most abundant fungal species, a representative of the Fusarium fujikuroi complex. Feeding on a particular plant taxon can thus have a specific fitness cost. Compared to the data collected from Northern Europe, the Argentinian assemblages from the families Aspergillaceae and Nectriaceae overlapped at the genus level but did not share species. It remains to be confirmed if this level of divergence in the composition of assemblages of entomopathogenic fungi among distant regions represents a global pattern.
Measuring continuity of care in general practice: a comparison of two methods using routinely collected data
Authors: Hull Sally A , Williams Crystal , Schofield Peter , Boomla Kambiz , Ashworth Mark 
Published: June 2022

BackgroundDespite well-documented clinical benefits of longitudinal doctor–patient continuity in primary care, continuity rates have declined. Assessment by practices or health commissioners is rarely undertaken.AimUsing the Usual Provider of Care (UPC) score this study set out to measure continuity across 126 practices in the mobile, multi-ethnic population of East London, comparing these scores with the General Practice Patient Survey (GPPS) responses to questions on GP continuity.Design and settingA retrospective, cross-sectional study in all 126 practices in three East London boroughs.MethodThe study population included patients who consulted three or more times between January 2017 and December 2018. Anonymised demographic and consultation data from the electronic health record were linked to results from Question 10 (‘seeing the doctor you prefer’) of the 2019 GPPS.ResultsThe mean UPC score for all 126 practices was 0.52 (range 0.32 to 0.93). There was a strong correlation between practice UPC scores measured in the 2 years to December 2018 and responses to the 2019 GPPS Question 10, Pearson’s r correlation coefficient, 0.62. Smaller practices had higher scores. Multilevel analysis showed higher continuity for patients ≥65 years compared with children and younger adults (β coefficient 0.082, 95% confidence interval = 0.080 to 0.084) and for females compared with males.ConclusionIt is possible to measure continuity across all practices in a local health economy. Regular review of practice continuity rates can be used to support efforts to increase continuity within practice teams. In turn this is likely to have a positive effect on clinical outcomes and on satisfaction for both patients and doctors.
Politeness Strategy in Commissive Speech Acts
Authors: Mudiharjo Devi Mulatsih , Nur Tajudin , Indrayani Lia Maulia , Darmayanti Nani 
Published: June 2022

Understanding comissive speech acts is important in oral or written communication because humans are often facing problems in communicating using language. So, someone can take action under the meaning, intention, and purpose of their utterance. In every speech act, not only the context, but also the utterance cannot be separated from the use of verbal utterance. This study specifically aims to describe and explain about politeness in commissive speech acts in a variety of speech situations. The research method used is the descriptive analysis method. The data in this study are the form of utterances contain in the conversation of film. The results of this study are founds 4 (four) types of commissive speech acts, they are: promise, swear, pledge (berniat), and vow (bernadar). While the politeness strategies in commissive speech acts include: (i) Cost-Benefit Scale found in promise, (ii) Optionally Scale in swear and pledge, (iii) Indirectness Scale found in promise, swear, and vow, (iv) Authority Scale found in swear that, (v) Social Distance Scale found in pledge.
Comparative Literature Analysis of The Folklore Between Goa Mampu and Bowerman’s Nose
Authors: Irwansyah Jumaldin , Taufik Muh. , Halim Nur Mutmainna , B Dahniar 
Published: June 2022

This research aims to: 1) identify the similarities and differences between the legend of Goa Mampu and Bowerman's Nose. 2) find out moral values behind the stories of Goa Mampu and Bowerman's Nose. The research method used in this research is the descriptive qualitative method. The researcher used a literature review to collect the data. The data obtained were folklore stories from the legend of Goa Mampu and the legend of Bowerman’s Nose. The data then analyzed by using the comparative literature method. The results of this research show that these two legends have similarities and differences. Similaritiy from two legends is only found in the minor theme both the legend of Goa mampu and Bowerman's Nose, told about curse and equivalence. On the other hand, differences from those two legends are found in the minor theme, major theme and in the background defiction of two legends. Goa Mampu’s minor theme was well-being, while Bowerman’s Nose’s minor theme was destiny of life. Meanwhile, Goa Mampu’s major theme was broken promises that lead to disaster, while Bowerman’s Nose’s major theme was errors culmination in punishments. Not only that, but the results of this research also found the moral value of the two legends. Namely, in the legend of Goa Mampu are 1) we shall be able to be independent and not to expect others. 2) think about everything before act, includ the spoken promises. 3) when we promise something, the promise must be fulfilled. And in the legend of Bowerman’s Nose are 1) in doing something we are required to have an introspective nature or be careful in our actions. 2) pay more attention to the surroundings while on the move. 3) what goes around, comes around.
Keywords: Bowerman’s Nose, Comparative Literature, Folklore, Goa Mampu.
A Hate and Provocative Speech Act in Social Media: A Forensic Linguistics Study
Authors: Sarifuddin Sarifuddin , Tadjuddin Maknun , Iswary Ery 
Published: June 2022

This study aims to: (1) explain the types of provocative speech acts of Natalius Pigai on YouTube social media, (2) explain the forms of provocative speech acts on YouTube social media. The data in this study are languages ​​that are supposed to contain provocative criminal acts on YouTube social media. The data source in this study is the social media YouTube. The method used in this research is descriptive qualitative method, data collection techniques in the form of viewing and documentation. The data were analyzed using the steps of (1) identifying, (2) classifying, and (3) analyzing. The results of this study indicate that: Natalis Pigai's utterances on social media contain literal indirect speech acts, while locutionary speech acts use declarative locutions, expressive illocutions, and get hearer to think about perlocutions (make the interlocutor think about). These statements violate the Criminal Code, Article 160 and Article 161 regarding sedition. Keywords: provocative speech acts, social media, forensic linguistics.
Keywords: provocative speech, social media, forensic linguistics.