bluuebunny/crossref_metadata_2025_split huggingface dataset:
Einflussfaktoren beim Aufbau von Präventionsketten in Neubaugebieten am Beispiel des Münchner Stadtteils Freiham – eine qualitative Studie
Authors: Voss Stephan , Coenen Michaela , Hummel Julia , Jung-Sievers Caroline , Zu Rhein Valerie , Rehfuess Eva 
Published: December 2022

Zusammenfassung
Einleitung
Präventionsketten sind integrierte kommunale Strategien zur Förderung von Gesundheit und sozialer Teilhabe von Kindern, Jugendlichen und Familien sowie zur Vermeidung der Folgen von Kinderarmut. Sie sind als intersektorale Netzwerke in mehreren Kommunen in Deutschland etabliert. Der Aufbau von Präventionsketten in Neubaugebieten wurde bislang noch nicht systematisch erforscht. Im Rahmen der Prozessevaluation zur Präventionskette Freiham, die in dem sich derzeit im Bau befindlichen gleichnamigen Münchner Stadtteil implementiert wird, wurde eine qualitative Interview- und Fokusgruppenstudie durchgeführt. Das Ziel war, relevante Einflussfaktoren für den Aufbau von Präventionsketten in einem neu entstehenden Stadtteil zu identifizieren.

Methoden
Für die Studie wurden wiederholt Interviews mit dem Netzwerkwerkmanagement der Präventionskette Freiham durchgeführt sowie eine Fokusgruppe mit Vertreter*innen der beteiligten städtischen Referate. Zudem fanden Interviews mit 12 lokalen Fachkräften aus den Sektoren Bildung, Soziales und Gesundheit statt. Die Auswertung erfolgte mit der Methode der qualitativen Inhaltsanalyse in Anlehnung an Mayring.

Ergebnisse
Wichtige Einflussfaktoren für eine gelingende Implementierung stellten aus Sicht der Teilnehmer*innen die Ausstattung mit finanziellen und personellen Ressourcen sowie die Unterstützung durch die kommunale Politik und Verwaltungsspitzen dar. Für eine erfolgreiche Arbeit im Netzwerk waren die zentrale Netzwerkkoordination, eine transparente Kommunikation, die Integration der unterschiedlichen Interessen der Akteur*innen und die Vermittlung eines Mehrwerts des Engagements entscheidend. Eine spezifische Herausforderung für das Setting eines Neubaugebiets war der Aufbau von bedarfs- und zielgruppenorientierten Netzwerkstrukturen angesichts einer zunächst geringen Anzahl an Bewohner*innen und noch nicht etablierter Unterstützungsstrukturen.

Schlussfolgerung
Ausreichende Finanzierung und Rückhalt in Politik und Verwaltung sind zentrale Einflussfaktoren für die Implementierung einer Präventionskette in Kommunen. Insbesondere in Neubaugebieten ohne gewachsene Infrastruktur erfordert der Aufbauprozess eine langfristig angelegte Unterstützung.
Review: CO2 capturing methods of the last two decades
Authors: Kammerer S. , Borho I. , Jung J. , Schmidt M. S. 
Published: December 2022

AbstractDue to the annual increase in CO2 emissions, climate change continues to progress. In order to achieve the goals set in the Paris Climate Agreement, CO2 capturing measures are necessary in addition to the reduction in carbon dioxide emissions. This review article describes and discusses the CO2 capturing methods published in the last 20 years. Processes for absorption, gas–solid reaction, adsorption, cryogenic processes, membrane processes and the capture of carbon dioxide with natural inclusion were examined in more detail.
Global existence and asymptotic behavior for a Timoshenko system with internal damping and logarithmic source terms
Authors: Cordeiro Sebastião Martins Siqueira , Pereira Ducival Carvalho , da Costa Baldez Carlos Alessandro , da Cunha Carlos Alberto Raposo 
Published: December 2022

AbstractThis manuscript deals with a Timoshenko system with damping and source. The existence and stability of the solution are analyzed taking into account the competition of the internal damping versus the logarithmic source. We use the potential well theory. For initial data in the stability set created by the Nehari surface, the existence of global solutions is proved using Faedo–Galerkin’s approximation. The exponential decay is given by the Nakao theorem. A numerical approach is presented to illustrate the results obtained.
Does the Public Health Security Capacity Provide Better Preparedness for Health Emergencies? A Cross-Sectional Analysis of 180 Countries During the COVID-19 Outbreak
Authors: Durmuş Veli 
Published: December 2022

Abstract

Objectives:
This study aimed to investigate the association between the health security capacities at the national level and preparedness for health emergencies in response to the COVID-19 outbreak.

Methods:
Data were extracted from the GHS report to evaluate the global health security capabilities in 180 countries. A linear regression analysis was performed with COVID-19 outcomes, as measured by the rate of incidence and vaccination doses, CFR, and PCR tests. Spearman correlation was used among potential explanatory factors.

Findings:
The GHS Index was inversely correlated with CFR and incidence rates, whereas it was positively associated with the vaccination and the PCR test rates. Countries with high health security capacities were significantly more likely to provide better preparedness for health emergencies in response to the outbreak. However, the vaccination doses’ rate and the number of PCR tests were significantly differ depending on countries’ income levels.

Conclusions:
Although health security capacity is essential to control public health emergencies effectively, it cannot predict whether or how well a country will use them in a crisis. Policymakers should identify their risk factors and capacity gaps and take into consideration the building of health security capacities in national budgets for long-term public health preparedness.
Comparison of Antarctic iceberg observations by Cook in 1772–75, Halley in 1700, Bouvet in 1739 and Riou in 1789 with modern data
Authors: Martin Seelye , Long David G. , Schodlok Michael P. 
Published: December 2022

AbstractDuring Cook's 1772–75 Antarctic circumnavigation on the HMS Resolution, he recorded the positions of hundreds of icebergs. This paper compares Cook's observations and those of Halley in 1700, Bouvet in 1739 and Riou in 1789, with the Brigham Young University/National Ice Center (BYU/NIC) and the Alfred Wegener Institute datasets. Cook's description of the iceberg plume east of the Amery Ice Shelf and the iceberg distributions in the Weddell, Ross and Amundsen Seas agree with modern data. In January 1774, Cook reached his farthest south on the shelf of the Amundsen Sea Embayment, the site of the current International Thwaites Glacier Collaboration field study. Cook's largest iceberg had a 2.5 km diameter, where power-law models show that icebergs of this size or smaller comprise 92% of their total number. In the eastern Weddell, Cook's observation of a sea-ice tongue with a much greater extent than in satellite imagery remains unexplained. Although Riou's icebergs lie 1000 km east of the BYU/NIC trajectories, application of the England and others (2020) fracture and drift model to the trajectories removes the discrepancy and means that all the ship observations are consistent with modern observations and theory.
Family Influence and Environmental Proactiveness of Family Firms in China: A Mixed Gamble Perspective
Authors: Liu Bin , Qian Gongming , Au Kevin Yuk-fai 
Published: December 2022

ABSTRACTBuilt upon the mixed gamble perspective, we used a recent survey on Chinese family firms (FFs) and found that increased family influence lowers Chinese FF environmental proactiveness, as they show a peculiar tendency to take a financial view rather than a socioemotional wealth view. Moreover, we found that increased resource endowment attenuates this tendency, whereas provincial marketization strengthens it. However, entrepreneur reputation does not have a significant moderating effect. Overall, the study enriches an understanding of environmental proactiveness for FFs, organizational heterogeneity, and institutional differences. It also introduces new elements into the mixed gamble framework.
Arterial switch operation and aortic valve replacement for transposition of great arteries in adulthood: two cases from a tertiary care centre in India
Authors: Mishra Anand Kumar , Patel Nishit , Raja Javid , Aggarwal Hiteshi , Bansal Vidur 
Published: December 2022

AbstractThe surgical treatment of transposition of the great arteries, ventricular septal defect, and significant left ventricular outflow tract obstruction continues to evolve. The survival of an unrepaired transposition of the great arteries into late adulthood is a rarity. Even when large intracardiac shunts are present, it remains a lethal cyanotic CHD if it is not surgically corrected soon after birth. We present our experience of two cases, both of whom underwent a single-stage arterial switch operation and an aortic valve replacement for this defect.
Parallel and identical test–retest reliability of the Tower of London test – Freiburg version
Authors: Schyle Valentin , Schumacher Lena V. , Rahm Benjamin , Unterrainer Josef M. 
Published: December 2022

AbstractObjectives:The Tower of London – Freiburg version (TOL-F) was developed in three parallel-test versions (A, B, and C) that only differ in their physical appearance by interchanged ball colors, but not in their cognitive demands. We addressed the question whether the test–retest reliability of an identical problem set differs from the parallel test–retest reliability of a structurally identical problem set with a marginally different physical appearance.Methods:Reliabilities were assessed in two samples of young adults over a 1-week interval: In the parallel test–retest sample (n = 93; 49 female), half of the participants accomplished version A at the first session and version B at the second session, while the other half started with version B in the first session and continued with A in the second session. In the identical test–retest sample (n = 86; 48 female), half of the participants performed on version A in both the first and the second session, while the other half went through the same procedure with version B.Results:For overall planning accuracy, intraclass correlation coefficients for absolute agreement were r = .501 for the parallel test–retest and r = .605 for the identical test–retest sample, with Pearson correlations of r = .559 and r = .708 respectively. Greatest lower bound estimates of reliability were adequate to high in the two samples (ranging between .765 and .854) confirming previous studies.Conclusions:Although the TOL-F revealed only moderate intraclass correlations for absolute agreement, it showed some of the highest psychometric indices compared to repeated assessments with other TOL tests.
Energetic Charged Particle Observations During Juno's Close Flyby of Ganymede
Authors: Clark G. , Kollmann P. , Mauk B. H. , Paranicas C. , Haggerty D. , Rymer A. , Smith H. T. , Saur J. , Allegrini F. , Duling S. , Ebert R. W. , Kurth W. S. , Gladstone R. , Greathouse T. K. , Li W. , Bagenal F. , Connerney J. E. P. , Bolton S. , Szalay J. R. , Sulaiman A. H. , Hansen C. J. , Turner D. L. 
Published: December 2022

AbstractOn 7 June 2021, NASA's Juno mission obtained unique measurements of Ganymede's magnetosphere during a close flyby that brought the spacecraft within ∼1,000 km of its surface. Here Jupiter Energetic particle Detector Instrument observations are presented and analyzed. The electron pitch angle distributions reveal distinct regions of Ganymede's magnetosphere that can be characterized as inbound and outbound magnetospheric boundaries, a magnetotail/wake region, and Ganymede's open field line region. Evidence for energy dependent electron pitch angle structuring is also documented both outside and within Ganymede's magnetosphere. Electron precipitation is observed and mapped to Ganymede's surface along Juno's magnetic footpoint.
Evidence for Magnetic Reconnection at Ganymede's Upstream Magnetopause During the PJ34 Juno Flyby
Authors: Ebert R. W. , Fuselier S. A. , Allegrini F. , Bagenal F. , Bolton S. J. , Clark G. , Connerney J. E. P. , DiBraccio G. A. , Kurth W. S. , Levin S. , McComas D. J. , Montgomery J. , Romanelli N. , Sulaiman A. H. , Szalay J. R. , Valek P. , Wilson R. J. 
Published: December 2022

AbstractJuno made a close flyby of Ganymede and flew through its magnetosphere on 7 June 2021, including an outbound crossing of Ganymede's upstream magnetopause. We present plasma and magnetic field observations near the upstream magnetopause from Juno's Jovian Auroral Distributions Experiment (JADE) and magnetometer. JADE observed enhanced electron fluxes, including field‐aligned electrons accelerated up to 2–3 keV/q, some having bidirectional pitch angle distributions, as Juno crossed Ganymede's magnetopause. Energy enhancements of cold protons and heavy ions originating from Ganymede were also observed on approach to the magnetopause. We interpret the presence of accelerated, field‐aligned electrons as indicating that magnetic reconnection is occurring on magnetic field lines that connect the spacecraft to Ganymede's magnetopause at that time. Counter‐streaming electrons observed on both sides of the magnetopause suggest the presence of multiple reconnection sites, both north and south of the spacecraft.
Electric Discharge in Erupting Mud
Authors: Springsklee C. , Manga M. , Scheu B. , Cimarelli C. , Dingwell D. B. 
Published: December 2022

AbstractSelf‐ignition during the explosive eruption of mud volcanoes can create flames that in some cases reach heights that exceed hundreds of meters. To study the controls on electrical discharge in natural mud, we performed laboratory experiments using a shock‐tube apparatus to simulate explosive eruptions of mud. We vary the water content of the mud and proportions of fine particles. We measure electric discharge within a Faraday cage and we use a high‐speed video camera to image the eruption of mud and some of the electric discharge events. We find that (a) decreasing the proportion of fine particles and (b) increasing water content each suppress the number and magnitude of electric discharge events. Experimentally observed mud volcano lightning occurs where particles exit from the vent and within the jet of erupting particles.
Chemical Compositions, Sources, and Intra‐Regional Transportation of Submicron Particles Between North China Plain and Twain‐Hu Basin of Central China in Winter
Authors: Hu Yao , Kong Shaofei , Zheng Huang , Zheng Shurui , Yao Liquan , Cheng Yi , Niu Zhenzhen , Chen Nan , Xu Ke , Wu Jian , Liu Dantong , Zhao Tianliang , Bai Yongqing , Qi Shihua 
Published: December 2022

AbstractRegional submicron particles (PM1) compositions, sources, and interaction are still not clear as the desynchrony in observation. This study focused on PM1 at five sites synchronously in North China Plain and Central China during January 2018. The average PM1 mass concentrations decreased from north to south, with higher values in Luohe (125 ± 59.4 μg m−3), followed by borderline cities (54.1–93.3 μg m−3) and a south site of Wuhan (63.6 ± 21.5 μg m−3). Organic matter (41.8%–51.0%) and secondary inorganic aerosols (SIAs; 28.2%–33.2%) occupied the high fractions for all the five sites. Coal combustion and industrial processes mainly raised the differences in PM1 chemical compositions between regions. The changes of NO3−/SO42− between sites were different as a function of relatively humidity and temperature, reflecting the differences of secondary formation mechanism. For a short intraregional transport case from south to north, PM1 increased from 102 to 185 μg m−3 as the accumulation and aerosol‐planet boundary layer interaction under a stable meteorological condition. For a long‐range transport case from north to south with a high wind speed (5.5 m s−1) and boundary layer height (529 m), PM1 decreased by only 0.9 μg m−3 (−1.3%) as the enhanced formation of SIA by 12.6% under increased relative humidity (by 7.2%) and enhanced industrial emission (by 19.1%) at the south site. The results provide a useful data set for modeling PM1 chemical compositions and their impacts and are helpful for regional‐joint control of atmospheric particles and precursor gases.
Global Modeling of Ganymede's Surface Composition: Near‐IR Mapping From VLT/SPHERE
Authors: King Oliver , Fletcher Leigh N. 
Published: December 2022

AbstractWe present maps of Ganymede's surface composition with almost complete longitude coverage, acquired using high spatial resolution near‐infrared (0.95–1.65 μm) observations from the ground‐based VLT/SPHERE instrument. Observed reflectance spectra were modeled using a Markov Chain Monte Carlo method to estimate abundances and associated uncertainties of water ices, acids, salts and a spectrally flat darkening agent. Results confirm Ganymede's surface is dominated by water ice in young bright terrain (impact craters, sulci), and low‐albedo spectrally flat material in older dark terrain (e.g., Galileo Regio). Ice grain size has strong latitudinal and longitudinal gradients, with larger grains at the equator and on the trailing hemisphere. These trends are consistent with the effects of the latitudinal thermal gradient and global variations in radiation driven sputtering. Sulfuric acid has a low abundance and appears potentially spatially correlated with plasma bombardment, where Ganymede's poles are exposed to the external Jovian magnetic field. Best‐estimate abundances suggest a mixture of salts could be present, although their low abundances, spectral degeneracies and associated uncertainties mean individual salt species cannot be detected with confidence. If present, sodium magnesium sulfate and magnesium chlorate appear tentatively correlated with exogenic plasma bombardment, while magnesium chloride and sulfate appear tentatively correlated with younger terrain, implying a possible endogenic origin. MCMC modeling was also performed on Galileo/NIMS data, showing comparable distributions. The high spatial resolution of SPHERE allows the precise mapping of small scale (<150 km) surface features, which could be used along with higher spectral resolution observations to jointly confirm the presence and distribution of potential species.
Preservation of Organic Matter in Aqueous Deposits and Soils Across the Mars‐Analog Qaidam Basin, NW China: Implications for Biosignature Detection on Mars
Authors: Chen Yan , Shen Jianxun , Liu Li , Sun Yu , Pan Yongxin , Lin Wei 
Published: December 2022

AbstractA variety of aqueous deposits and soils from gullies, fluvial channels, mountain slopes, alluvial fans, playas, polygons, and yardangs have been found on Mars. However, the occurrence of sedimentary organic matter (SOM) in these landscapes under hyperarid and strongly radiative conditions has yet to be fully assessed. With various desiccated landforms analogous to those on Mars, the Qaidam Basin in northwestern China is considered a promising hyperarid Martian analog. Here, aqueous deposits and soils from nine landforms across the extremely dry northwestern Qaidam and from four landforms across the dry southeastern Qaidam were sampled and investigated. Our results reveal that landform and moisture are important controls on organic carbon distribution across the Qaidam Basin, while sedimentary origin has a dominant effect in the extremely dry northwestern Qaidam. Combined with previous studies, low organic carbon contents of soils in the extremely dry northwestern Qaidam suggest possibly low rates of microbial carbon input and of organic carbon degradation in Mars‐like environments. High organic carbon contents of aqueous deposits together with increasing trends along rivers indicate preservation of relic SOM and possibly slow degradation rates of organic matter as compared to their exposure timescale. Moreover, soils from the distal alluvial fan are found to favor the concentration of pedogenic organic carbon as compared to those from other landforms in the dry southeastern Qaidam and from all landforms in the extremely dry northwest. This suggests that subsoils in the distal fans are promising candidate targets for biosignature detection on Mars.
Brain metastatic outgrowth and osimertinib resistance are potentiated by RhoA in EGFR-mutant lung cancer
Authors: Adua Sally J. , Arnal-Estapé Anna , Zhao Minghui , Qi Bowen , Liu Zongzhi Z. , Kravitz Carolyn , Hulme Heather , Strittmatter Nicole , López-Giráldez Francesc , Chande Sampada , Albert Alexandra E. , Melnick Mary-Ann , Hu Bomiao , Politi Katerina , Chiang Veronica , Colclough Nicola , Goodwin Richard J. A. , Cross Darren , Smith Paul , Nguyen Don X. 
Published: December 2022

AbstractThe brain is a major sanctuary site for metastatic cancer cells that evade systemic therapies. Through pre-clinical pharmacological, biological, and molecular studies, we characterize the functional link between drug resistance and central nervous system (CNS) relapse in Epidermal Growth Factor Receptor- (EGFR-) mutant non-small cell lung cancer, which can progress in the brain when treated with the CNS-penetrant EGFR inhibitor osimertinib. Despite widespread osimertinib distribution in vivo, the brain microvascular tumor microenvironment (TME) is associated with the persistence of malignant cell sub-populations, which are poised to proliferate in the brain as osimertinib-resistant lesions over time. Cellular and molecular features of this poised state are regulated through a Ras homolog family member A (RhoA) and Serum Responsive Factor (SRF) gene expression program. RhoA potentiates the outgrowth of disseminated tumor cells on osimertinib treatment, preferentially in response to extracellular laminin and in the brain. Thus, we identify pre-existing and adaptive features of metastatic and drug-resistant cancer cells, which are enhanced by RhoA/SRF signaling and the brain TME during the evolution of osimertinib-resistant disease.
PEAC-seq adopts Prime Editor to detect CRISPR off-target and DNA translocation
Authors: Yu Zhenxing , Lu Zhike , Li Jingjing , Wang Yingying , Wu Panfeng , Li Yini , Zhou Yangfan , Li Bailun , Zhang Heng , Liu Yingzheng , Ma Lijia 
Published: December 2022

AbstractCRISPR technology holds significant promise for biological studies and gene therapies because of its high flexibility and efficiency when applied in mammalian cells. But endonuclease (e.g., Cas9) potentially generates undesired edits; thus, there is an urgent need to comprehensively identify off-target sites so that the genotoxicities can be accurately assessed. To date, it is still challenging to streamline the entire process to specifically label and efficiently enrich the cleavage sites from unknown genomic locations. Here we develop PEAC-seq, in which we adopt the Prime Editor to insert a sequence-optimized tag to the editing sites and enrich the tagged regions with site-specific primers for high throughput sequencing. Moreover, we demonstrate that PEAC-seq could identify DNA translocations, which are more genotoxic but usually overlooked by other off-target detection methods. As PEAC-seq does not rely on exogenous oligodeoxynucleotides to label the editing site, we also conduct in vivo off-target identification as proof of concept. In summary, PEAC-seq provides a comprehensive and streamlined strategy to identify CRISPR off-targeting sites in vitro and in vivo, as well as DNA translocation events. This technique further diversified the toolkit to evaluate the genotoxicity of CRISPR applications in research and clinics.