bluuebunny/crossref_metadata_2025_split huggingface dataset:
“A Leader, That’s A Verb”: A Discursive Analysis of Lived Experience Leadership Per its Construction by People with Lived Experience
Authors: Stewart Stephanie , Kennedy Hamilton , Warner Terri , Edan Vrinda , Makuvachuma Dominic , Griffiths Scott , Scholz Brett , Roper Cath 
Published: March 2022

Abstract
Lived experience leadership is championed as key to realising progressive change across the mental health sector. This article represents an effort to diminish the hermeneutical lacuna associated with lived experience leadership, and so redress an identified barrier to its advancement. Herein, we present an analytic account of the defining features of lived experience leadership. Interviews were conducted with 19 people identified by their peers as lived experience leaders regarding their views on lived experience leadership and related concepts such as power, authority, influence and leadership more generally. Per our discursive analysis of interview data, lived experience leadership is constituted by acts realised via the use of a specific type of power- people with lived experience’s experience-based and systems-informed knowledge of and fidelity to themselves as both individuals and as a collective- and directed towards increasing others’ access to this power. Results suggest how lived experience leadership might be distinguished from other similar practices, and may be utilised as a tool with which to promote its proliferation.
C-reactive Protein Levels and Cardiovascular Outcomes After Febuxostat Treatment in Patients with Asymptomatic Hyperuricemia: Post-hoc Analysis of a Randomized Controlled Study
Authors: Kojima Sunao , Uchiyama Kazuaki , Yokota Naoto , Tokutake Eiichi , Wakasa Yutaka , Hiramitsu Shinya , Waki Masako , Jinnouchi Hideaki , Kakuda Hirokazu , Hayashi Takahiro , Kawai Naoki , Sugawara Masahiro , Mori Hisao , Tsujita Kenichi , Matsui Kunihiko , Hisatome Ichiro , Ohya Yusuke , Kimura Kazuo , Saito Yoshihiko , Ogawa Hisao 
Published: March 2022

Abstract
Purpose: Inflammation plays an important role in the initiation and progression of atherosclerosis, leading to poor clinical outcomes. Hyperuricemia is associated with the activation of the Nod-like receptor protein 3 inflammasome. Here, we investigated whether inhibition of inflammation using febuxostat lowered the risk of cardiovascular events. Methods: This is a post-hoc analysis of the randomized trial, Febuxostat for Cerebral and CaRdiorenovascular Events PrEvEntion StuDy (FREED). In total, 1,067 patients (736 men and 331 women) were included in the analysis. We compared the serial changes in high-sensitivity C-reactive protein (hs-CRP) levels between febuxostat and non-febuxostat groups and assessed the correlation between the changes in uric acid (UA) and hs-CRP levels after febuxostat treatment. We also determined whether febuxostat could reduce a hard endpoint, defined as a composite of cardiovascular events and all-cause mortality. Results: Serum UA levels in the febuxostat group were significantly lower than those in the non-febuxostat group after randomization (p<0.05). However, hs-CRP levels were comparable between the two groups during the study. No significant correlation was observed between the changes in UA and hs-CRP levels after febuxostat treatment. The hard endpoints did not differ significantly between the two groups. In patients with baseline hs-CRP levels > 0.2 mg/dL or those administered 40 mg of febuxostat, the drug did not reduce hs-CRP levels or decrease the hard endpoint. Conclusion: Febuxostat reduced the UA levels but did not affect the CRP levels, and therefore may fail to decrease cardiovascular outcomes after treatment. Trial Registration: ClinicalTrial.gov (NCT01984749).https://clinicaltrials.gov/ct2/show/NCT01984749
Comprehensive analysis of Six2-mediated transcriptional regulatory network in ccRCC
Authors: Tian Dayu , Shi Yang , Lei Li , Qiu Xiangmin , Song Tao , Li Qianyin 
Published: March 2022

Abstract
BackgroundSix2, a transcription factor, exerts an oncogenic role in clear cell renal cell carcinoma (ccRCC). Increased Six2 expression could enhance cancer metastasis. However, the regulatory action of Six2 remains unclear in cancer. The purpose of this study is to analyze the regulatory pattern and potential downstream effectors of Six2.MethodsFirstly, transcriptional data in TCGA-KIRC cohorts was used to analyze the relationship between Six2 expression and clinical information. Then, we analyzed Six2-related differentially expressed genes (DEGs) and constructed a prognostic model using the Lasso-Cox algorithm by integrating Six2 ChIP data and co-expressed genes. Next, we analyzed the clinical significance of this model and examined the DEGs between the high-and low-risk group. Finally, we intersected the GO and KEGG pathway results between Six2-related DEGs and risk-related DEGs to reveal biological functions in which Six2 is involved.ResultsSix2 was increased in RCC cells compared with normal kidney cells and upregulated Six2 was positively linked with clinical stage, M stage, and worse survival. Potential downstream effectors and biological functions regulated by Six2 were identified using in silico analysis. Meanwhile, a risk model based on 8 Six2 target genes was established to classify ccRCC patients into high-and-low groups. This risk model showed a reliable ability to forecast the overall survival of ccRCC patients. Shared enriched pathways were found between the Six2 high-and low-expression and risk groups, such as epithelial-to-mesenchymal transition, PI3K-Akt pathway, etc.ConclusionOur findings provide a promising prognostic indicator for ccRCC patients and help better understand the transcriptional role of Six2 in ccRCC.
Pressure Driven Rotational Isomerism in 2D Hybrid Perovskites
Authors: Yin TingTing , Yan Hejin , Abdelwahab Ibrahim , Lekina Yulia , Lü Xujie , Yang Wenge , Sun Handong , Leng Kai , Cai Yongqing , Shen Ze , Loh Kian Ping 
Published: March 2022

Abstract
Multilayers consisting of alternating soft and hard layers offer enhanced toughness compared to all-hard structures. However, shear instability usually exists in physically sputtered multilayers because of deformation incompatibility among hard and soft layers. Here, we demonstrate that 2D hybrid organic-inorganic perovskites (HOIP) provide an interesting platform to study the stress-strain behavior of hard and soft layers undulating with molecular scale periodicity. We investigate the phonon vibrations and photoluminescence properties of Ruddlesden-Popper perovskites (RPPs) under hydrostatic compression using a diamond anvil cell. The C4 alkyl chain in RPP as the organic spacer buffers compressive stress by tilting (for n = 1 RPP) or step-wise rotational isomerism (for n > 1 RPP) during compression. By examining the pressure threshold of the elastic recovery regime across n = 1 to n = 4 RPP perovskites, we obtained molecular insights into the relationship between structure and deformation resistance in hybrid organic-inorganic perovskites.
Qualitative comparative analysis of the implementation fidelity of a workplace sedentary reduction intervention
Authors: Leonard Krista S. , Mullane Sarah L. , Golden Caitlin A. , Rydell Sarah A. , Mitchell Nathan R. , Koskan Alexis , Estabrooks Paul A. , Pereira Mark A. , Buman Matthew P. 
Published: March 2022

Abstract
Background: Stand and Move at Work was a 12-month, multicomponent, peer-led (intervention delivery personnel) worksite intervention to reduce sedentary time. Although successful, the magnitude of reduced sitting time varied by intervention worksite. The purpose of this study was to use a qualitative comparative analysis approach to examine potential explanatory factors that could distinguish higher from lower performing worksites based on reduced sitting time. Methods: We assessed 12-month changes in employee sitting time objectively using accelerometers at 12 worksites. We ranked worksites based on the magnitude of change in sitting time and categorized sites as higher vs. lower performing. Guided by the integrated-Promoting Action on Research Implementation in Health Services framework, we created an indicator of intervention fidelity related to adherence to the protocol and competence of intervention delivery personnel (i.e., implementer). We then gathered information from employee interviews and surveys as well as delivery personnel surveys. These data were aggregated, entered into a truth table (i.e., a table containing implementation construct presence or absence), and used to examine differences between higher and lower performing worksites. Results: There were substantive differences in the magnitude of change in sitting time between higher (-75.2min/8h workday, CI95: -93.7, -56.7) and lower (-30.3min/8h workday, CI95: -38.3, -22.7) performing worksites. Conditions that were present in all higher performing sites included implementation of indoor/outdoor walking route accessibility, completion of delivery personnel surveys, and worksite culture supporting breaks (i.e., adherence to protocol). A similar pattern was found for implementer willingness to continue role and employees using face-to-face interaction/stair strategies (i.e., delivery personnel competence). However, each of these factors were also present in some of the lower performing sites suggesting we were unable to identify sufficient conditions to predict program success. Conclusions: Higher intervention adherence and implementer competence is necessary for greater program success. These findings illustrate the need for future research to identify what factors may influence intervention fidelity, and in turn, effectiveness. Trial registration: ClinicalTrials.gov Identifier: NCT02566317. Registered 2 October 2015, first participant enrolled 11 January 2016.
Prehospital Portable Ultrasound for Safe and Accurate Pre-hospital Needle Thoracostomy: A Pilot Educational Study
Authors: Dewar Zachary E. , Ko Stephanie , Rogers Cameron , Oropallo Alexis , Augustine Andrew , Pamula Ankitha , Berry Christopher 
Published: March 2022

Abstract
Background:Simulated needle thoracostomy (NT) using ultrasound would reduce potential injury, increase accuracy, and be as rapid to perform as the landmark technique following a brief educational session. Our objective was to determine if the use of an educational session demonstrating the use of handheld ultrasound to Emergency Medical Services (EMS) staff to facilitate NT is an effective way of increasing the safety and efficacy of this procedure for rural EMS providers.Methods:A pre/post educational intervention on a convenience sample of rural EMS paramedics and nurses. Measurement of location and estimated depth of placement of needle thoracostomy with traditional landmark technique was completed and then repeated using handheld ultrasound following a training session on thoracic ultrasound and correct placement of NT.Results:A total of 30 EMS practitioners participated. Seven were female (23.3%). There was a higher frequency of dangerous structures underlying the chosen location with the landmark technique 9/60 (15%) compared to the ultrasound technique 1/60 (1.7%) (p = 0.08). Mean time-to-site-selection for the landmark technique was shorter than the ultrasound technique at 10.7s (Range 3.35-45s) vs. 19.9s (range 7.8-50s), respectively (p < 0.001). There was a lower proportion of correct location selection for the landmark technique 40/60 (66.7%) when compared to the ultrasound technique 51/60 (85%) (p = 0.019). With ultrasound, there was less variance between the estimated and measured depth of the pleural space with a mean difference of 0.033 cm (Range 0-0.5 cm) when ultrasound was used as compared to a mean difference of 1.0375 cm (Range 0–6 cm) for the landmark technique (95% CI for the difference 0.73–1.27 cm; p < 0.001).Conclusions:Teaching ultrasound NT was feasible in our cohort. While time to site selection for ultrasound-guided NT took longer than the landmark technique, it increased safe and accurate simulated NT placement with fewer identified potential iatrogenic injuries.
Characterizing behavior changes in mice receiving splenectomy
Authors: Guan Jiao-Qiong , Zhang Pei-Sen , Zhang Wen-Chao , Zhang Bing-Qian , Wu Hai-Tao , Lan Yue , Yuan Ti-Fei 
Published: March 2022

Abstract
Background Spleen is critical for immunity. The spleen is the largest immune organ and immune center in the peripheral system. The relationship between behavior and immunity has been fully reflected in physiology and diseases, however, the role of the spleen in behavior is not clear. Methods To explore the potential effects of spleen on behavior, here we developed refined splenectomy procedure on C57BL/6J mice. And then systemically examined the changes in general locomotion, circadian rhythms, learning and memory, depression/anxiety-related behaviors. Results Interestingly, splenectomy has no significant effects on these baseline behavioral performances. To further understand the effect of spleen on stress susceptibility/resilience, we applied chronic unpredictable mild stress (CUMS) in our animal model. The behavioral performances of mice with splenectomy showed no differences from control animals following systemic challenge with CUMS. Conclusion These results suggested that splenectomy does not cause significant changes in baseline behavior performances in mice, which provides an important strategy in manipulating peripheral immunity for neuroscience research.
Change Rate in Serum Nitric Oxide May Affect Lenvatinib Therapy in Hepatocellular Carcinoma
Authors: Kawamura Atsushi , Uojima Haruki , Chuma Makoto , Shao Xue , Hidaka Hisashi , Nakazawa Takahide , Take Akira , Sakaguchi Yoshihiko , Numata Kazushi , Kako Makoto , Nozaki Akito , Azuma Shintaro , Horio Kazue , Kusano Chika , Atsuda Koichiro 
Published: March 2022

Abstract
Background: Lenvatinib is appropriate for reducing the production of nitric oxide (NO) and facilitating as block angiogenesis. However, to our knowledge, there are no data that support the correlation between NO and clinical response in patients who received lenvatinib therapy for HCC. Therefore, we investigated whether or not NO influence a therapeutic response and adverse events (AEs) after lenvatinib therapy for unresectable hepatocellular carcinoma (HCC).Methods: This study was conducted using previously collected data from another study. We enrolled 70 patients who received lenvatinib for advanced or unresectable HCC. NO was measured by converting nitrate (NO3–) to nitrite (NO2–) with nitrate reductase, followed by quantitation of NO2– based on Griess reagent. To determine whether lenvatinib influences NO in unresectable HCC, we evaluated the influence of maximal therapeutic response and SAE on the change rate of NO from baseline after administration of lenvatinib.Results: After lenvatinib administration, a change rate in the NO from 0.27 to 4.16 was observed. There was no difference between the clinical response to lenvatinib and the change rate of NO (P = 0.193). However, the change rate of NO was significantly higher in patients with AEs than in those without AEs (P = 0.013). When a reduction in NO rate of < 0.8 was defined as a clinically significant reduction of NO (CSRN), the CSRN group had significantly worse progression-free survival (PFS) and overall survival (OS) than the non-CSRN group (P = 0.040 and P = 0.005, respectively)ConclusionDecreased NO levels were associated with the occurrence of AEs and worse prognosis after lenvatinib administration. Change rate in serum NO can be used as predictive markers in patients receiving lenvatinib therapy for HCC.
Learning and Evaluating the Overlapping Role of Physics and Physiology in Perceiving Contrast and Resolution in Microscopy
Authors: Rajdeep Prashant , Patel Lajja , Trivedi Vismay , Panchal Preeti , Chaudhari Rinkesh , Parmar kinjal 
Published: March 2022

Abstract
Introduction:
Contrast and resolution have been fascinating to the students, as both interweave physics and physiology. Both these entities can be studied beyond the limits of the textbook on hands-on basis.
Objective
Determining contrast and resolution through human perception and technological tools for their quantification and estimation of the degree of overlap between the two disciplines.
Materials & Methods
An opaque repository for compound microscope with a mobile holder was devised to capture the images of Leishman stained smear. Another receptacle was fabricated to hold different coloured filters against a light bulb, which projected on the microscope mirror through a connecting pipe. The images with a different sequence of filters were subjected to analysis by human eye and also by digital image processing techniques.
Results
Perception of contrast and resolution through human eye and digital processing shows overlapping of 82.57% for contrast and 76.40% for resolution. Furthermore, white colour light was preferred for both contrast and resolution independently as well as combined, with propensity for contrast above resolution.
Conclusion
By comparing the effect of different filters on contrast and resolution, the integrated role of physics and physiology can be studied. Simultaneously, the subjective selection of resolution or contrast by using low-cost filters can be an affordable approach to upgrade the microscope.
The association between Healthy Beverage Index and quality of life among overweight and obese women: A cross-sectional study
Authors: Rasaei Niloufar , Ghaffarian-Ensaf Rasool , Shiraseb Farideh , Fallah Melika , Gholami Fatemeh , Mirzaei Khadijeh 
Published: March 2022

Abstract
Background: Despite the several studies evaluated the association between patterns of beverage consumption with different components of quality of life separately, the findings are controversial. In addition, none of them examined all components of quality of life together in relation to patterns of beverage consumption. Therefore, this study was conducted to identify the association between healthy beverage index (HBI) and quality of life among overweight and obese women. Methods: For this cross-sectional study, 210 obese and overweight women were chosen from health centers in Tehran, Iran. Using reliable and verified standard protocols, data on beverage intake, socio-demographic, physical activity, and anthropometric variables were assessed. Based on past studies, the predetermined HBI was estimated. Serum samples were used to determine biochemical characteristics. Quality of life was assessed using SF-36 questionnaires.Results: There was a significant association between total QoL score with T2 tertile of HBI in model 2 adjustment (β: 13.11, 95% CI: 1.52, 24.69, P-value= 0.027). general health had a significant negative association with T2 (β: -5.83; 95% CI: -11.48, -0.18; P-value= 0.043) and T3 (β: -6.20; 95% CI: -12.37, -0.03; P-value= 0.049). Women with more adherence of HBI, have the high physical functioning score and there was a significant upward trend with the movement from the second to the third tertile (7.74 vs 0.62) (P-trend=0.036). There was a significant positive association between mental health with T3 of HBI (β: 4.26; 95% CI: 1.51, 5.98; P-value= 0.015) and a significant increasing trend was observed with increasing tertiles (P-trend= 0.045).Conclusion: In conclusion, there is a significant association between total QoL score and its components with HBI among overweight and obese women. However, additional well-designed studies are needed to confirm these findings.
Carbonic Anhydrase IX Stratifies Patient Prognosis and Identifies Nodal Status in Nasopharyngeal Carcinoma Using a Targeted Imaging Strategy
Authors: Huang Wenhui , Wang Kun , Huang Weiyuan , He Zicong , Zhang Jingming , Zhang Bin , Xiong Zhiyuan , Gillen Kelly McCabe , Li Wenzhe , Chen Feng , Yang Xing , Zhang Shuixing , Tian Jie 
Published: March 2022

Abstract
Purpose: Accurate identification of nodal status enables adequate neck irradiation for nasopharyngeal carcinoma (NPC). However, most conventional techniques are unable to pick up occult metastases, leading to underestimation of tumor extensions. Here we investigate the clinical significance of carbonic anhydrase IX (CAIX) in human NPC samples, and develop a CAIX-targeted imaging strategy to identify occult lymph node metastases (LNMs) and entranodal extension (ENE) in animal studies. Methods: 211 NPC samples are stained for CAIX and clinical outcomes are analyzed. The metastatic murine models are generated by foot pad injection of NPC cells, and a CAIX-targeted imaging agent (CAIX-800) is intravenously administered. We adopt fluorescence molecular tomography and ultrasonography (US)-guided spectroscopic photoacoustic (sPA) imaging to perform in vivo studies. Histological and immunohistochemical characterization are carried out via node-by-node analysis. Results: For clinical samples, 90.1% (91/101) primary tumors, 73.3% (66/90) metastases and 100% (20/20) local recurrences are CAIX positive. In metastases group, 84.7% (61/72) nodal metastases and 22.2% (4/18) organ metastases are CAIX positive. CAIX expression in primary tumors is significantly associated with NPC stage and prognosis. For animal studies, CAIX-800 based fluorescence imaging achieves 81.3% sensitivity and 93.8% specificity in detecting occult LNMs in vivo, with a minimum detectable diameter of 1.7 mm. Coupled with CAIX-800, US-guided sPA imaging could not only detect subcapsular deposits of metastatic cancer cells two weeks earlier than conventional techniques, but also successfully track pathological ENE. Conclusion: CAIX remarkably expresses in human NPCs and stratifies patient prognosis. In preclinical studies, the CAIX-800 based imaging strategy successfully identifies occult LNMs and tracks early stage of pathological ENE. This attractive method shows great translational potential, allowing medical workers to longitudinally monitor nodal status and helping to reduce unnecessary nodal biopsy for NPC patients.
Deepfakes and Scientific Knowledge Dissemination
Authors: Doss Christopher , Monschein Jared , Shu Dule , Wolfson Tal , Kopecky Denise , Fitton-Kane Valerie A. , Bush Lance , Tucker Conrad 
Published: March 2022

Abstract
Science misinformation on topics ranging from climate change to vaccines have significant public policy repercussions. Artificial intelligence-based methods of altering videos and photos (deepfakes) lower the barriers to the mass creation and dissemination of realistic, manipulated digital content. The risk of exposure to deepfakes among education stakeholders has increased as learners and educators rely on videos to obtain and share information. We detail the results of the first study to understand the vulnerabilities of education stakeholders to science deepfakes and the characteristics that moderate vulnerability. We ground our study in climate change and survey individuals from five populations spanning students, educators, and the adult public. Our sample is nationally representative of three populations. We found that 33% to 50% of individuals cannot distinguish between authentic videos and deepfakes. All populations exhibit vulnerability to deepfakes, but vulnerability varies with age, political orientation, and trust in information sources. Adults and educators exhibit greater vulnerability compared to students, indicating that those providing education are especially susceptible. Vulnerability increases with more exposure to potential deepfakes, suggesting that deepfakes become more pernicious without interventions. Our results suggest that focusing on the social context in which deepfakes reside is one promising strategy for combatting deepfakes.