bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Clinical Impact of pT3a Lesions in Patients With pT3b Prostate Cancer Undergoing Radical Prostatectomy
Authors: Numbere Numbereye , Teramoto Yuki , Gurung Pratik M. S. , Goto Takuro , Yang Zhiming , Miyamoto Hiroshi 
Published: January 2022

Context.—
Seminal vesicle invasion (SVI) by prostate cancer (pT3b disease) has been considered as a key prognostic factor.

Objective.—
To assess the clinical impact of T3a lesions (ie, extraprostatic extension other than bladder neck invasion [BNI] or SVI [EPE], microscopic bladder neck invasion [mBNI]) in pT3b disease.

Design.—
We compared radical prostatectomy findings and long-term oncologic outcomes in 248 patients with pT3b disease, with versus without EPE/mBNI.

Results.—
Extraprostatic extension/mBNI was found in 219 (88.3%)/48 (19.4%) cases, respectively. Extraprostatic extension was significantly associated with higher preoperative prostate-specific antigen (PSA) level, higher rates of positive surgical margin (pSM) and lymphovascular invasion (LVI), and larger tumor volume. Similarly, mBNI was significantly associated with higher PSA level, higher rates of Grade Group(s) 4-5 or 5, pSM, LVI, and pN1, and larger tumor volume. Significant differences in all of these clinicopathologic features (except lymph node metastasis) between EPE−/mBNI+ or EPE+/mBNI− and EPE+/mBNI+ cases were also observed. Outcome analysis revealed that patients with EPE (P &lt; .001) or mBNI (P &lt; .001) had a significantly higher risk of disease progression than respective controls. Notably, there were significant differences in progression-free survival between EPE−/mBNI+ or EPE+/mBNI− cases and EPE−/mBNI− (P = .001) or EPE+/mBNI+ (P &lt; .001) cases. In multivariate analysis, EPE (hazard ratio [HR] = 6.53, P = .009) and mBNI (HR = 2.33, P = .003), as well as EPE−/mBNI+ or EPE+/mBNI− (HR = 11.7, P = .01) and EPE+/mBNI+ (HR = 25.9, P = .002) versus EPE−/mBNI−, showed significance for progression.

Conclusions.—
From these significant findings, we propose a novel pT3b subclassification: pT3b1 (SVI alone without EPE or mBNI), pT3b2 (SVI with either EPE or mBNI), and pT3b3 (SVI with both EPE and mBNI).
Corporate Governance and Reliability of Financial Reporting in Central Government Agencies
Authors: Arcas-Pellicer Maria-Jose , Pina Vicente , Torres Lourdes 
Published: January 2022

The objective of this paper is to determine the effects of the corporate governance practices of central government agencies on the reliability of ﬁnancial reporting. There has been a considerable growth of these agencies across countries, and there are no studies about the relationship between the features of their corporate governance and the level of reliability of their financial reports. This paper provides evidence of systematic upward earnings management by agencies that apply the Private Sector Chart of Accounts to improve their financial performance and to compensate for the reduction of revenues during the worst years of the financial crisis. The results also show that abnormal accruals have a significant and inverse relationship with the percentage of independent directors and women on the boards, i.e., diversity improves the reliability of the financial information of these entities.
El objetivo de este trabajo es determinar los efectos que tienen las prácticas de gobierno corporativo de las agencias públicas estatales sobre la fiabilidad de su información financiera. Se ha producido un considerable aumento de estas agencias en muchos países; sin embargo, no hay estudios sobre la relación entre las características de su gobierno corporativo y el nivel de fiabilidad de sus estados financieros. Este artículo proporciona evidencia de que hay una estrategia de aumentar el resultado entre las agencias que aplican el Plan General de Contabilidad, para mejorar su rendimiento financiero y compensar la reducción de ingresos durante los peores años de la crisis financiera. En relación al gobierno corporativo, los resultados también muestran que los devengos discrecionales tienen una relación inversa significativa con el porcentaje de consejeros independientes y mujeres en los consejos, esto es, la diversidad del consejo mejora la fiabilidad de la información financiera de estas entidades.
Fernando Candón Ríos: "La semántica del poder. La poesía de Benjamín Prado"
Authors: Hidalgo Saavedra Joaquín 
Published: January 2022

Con esta reseña pretendemos dar a conocer y analizar brevemente la obra del profesor Candón Ríos, La semántica del poder, un libro en el que, desde un marco teórico sólido y con un enfoque multidisciplinar, se pretende, de manera crítica y consciente, además de minuciosa, realizar un estudio que defiende la influencia de diversos factores extraliterarios que situaron al grupo de los poetas de la experiencia (en general) y a Benjamín Prado (en particular) en el buen lugar que ocupan en la historia de la literatura española. El libro, además de los contenidos explicados, aporta, en sentido global, un ejemplo de una manera diferente de abordar los estudios literarios, una forma más amplia y plural.
Identidad, negación y emancipación: una lectura de Reivindicación del Conde don Julián de Juan Goytisolo desde la dialéctica hegeliana
Authors: Iglesias-Crespo Carlos 
Published: January 2022

Este artículo propone un análisis de la emancipación del yo narrativo de Reivindicación del Conde don Julián (1970) de Juan Goytisolo desde la dialéctica hegeliana. Para desarrollar nuestra hipótesis, ofrecemos una breve exposición de los principios de la dialéctica hegeliana como paso previo al análisis propiamente dicho, donde se propone una nueva manera de entender la novela que permite matizar las opiniones de aquellos críticos que consideran que Don Julián es un proyecto fallido. Nada más lejos de la realidad: una perspectiva hegeliana permite constatar cómo Don Julián, pese a sus tensiones estructurales, ideológicas y subjetivas, no es víctima de su aparente cierre sobre sí misma, sino que supone una pieza fundamental para comprender la evolución de la identidad del yo narrativo en la obra de Goytisolo
Volver para desenterrar a los muertos. La encrucijada identitaria de Cristina Fallarás en Honrarás a tu padre y a tu madre
Authors: De Benitio Iris 
Published: January 2022

Este ensayo se propone hacer un análisis textual y contextual de la novela Honrarás a tu padre y a tu madre [2018], de Cristina Fallarás, en la que la autora lleva a cabo una revisión identitaria impulsada por la investigación de su pasado fmiliar. Para el análisis, se relaciona en un primer momento la obra con otras de temática y contenido similar, tambien producidas en el periodo de tiempo que va desde las últimas décadas hasta la actualidad. Asimismo, se realiza una aproximación a los usos de la autoficción y la docuficción que la obra propone, del mismo modo que se presta atención a la hibridación de géneros narrativos y textuales como el discurso periodístico, la autobiografía, la novela de investigación o el género policial. Por otra parte, el estudio se centrará en ciertos aspectos en los que la dialéctica entre el contenido de la obra y su disposición formal confluyen en una misma unidad de sentido, rasgo al que tampoco escaparán algunos elementos paratextuales.
Assessment of health-related quality of life in hypertensive hemodialysis patients
Authors: Aslam Ayesha , Shah Shahid , Abbas Ghulam , Rehman Anees ur , Malhi Tauqeer Hussain , Alotaibi Nasser Hadal , Alzarea Abdulaziz Ibrahim , Rasool Muhammad Fawad , Khurram Haris , Noureen Sibgha , Saeed Bokhari Muhammad Talha 
Published: January 2022

Background and Objectives
Globally, the prevalence of hypertension (HTN) with the coexistence of chronic kidney disease (CKD) is increasing, resulting in poor quality of life. The main objective of the study was to measure the health-related quality of life (HRQoL) of hypertensive hemodialysis patients.

Methods
A multicenter follow-up study was carried out in six public and two private dialysis centers in Pakistan. A total of 517 hypertensive hemodialysis patients responded by completing the questionnaire at baseline and two subsequent phases. The quality of life of these patients was assessed using the EQ-5D-5L questionnaire (a standardized instrument for measuring generic health status). Statistical analysis was done using a multivariate linear regression model, Friedman test and Kruskal Wallis test.

Results
The majority of patients (58.2%) had normal body mass index and about 60.5% of the patients were taking less salt due to HTN. Friedman test gave the statistically significant results (p ≤ 0.001) in systolic blood pressure (BP), diastolic BP and EQ-5D visual analogue scale (VAS) score between three phases (initial visit, first follow-up and second follow-up). A significant improvement was observed in self-care and usual activities from initial visit to first follow-up (p < 0.05). The most problematic dimension among the hypertensive patients with CKD was pain/discomfort (86.5%).

Conclusions
HTN with coexisting CKD in hemodialysis patients severely affected HRQoL. Pain/discomfort was the most problematic dimension among the participants.
Identification of the occurrence and potential mechanisms of heterotopic ossification associated with 17-beta-estradiol targeting MKX by bioinformatics analysis and cellular experiments
Authors: Zhang Yunpeng , Zhang Jingwei , Sun Chenyu , Wu Fan 
Published: January 2022

Background
Tendon heterotopic ossification (HO) is a common condition occurring secondary to tendon injury or surgical trauma that significantly affects the patient’s quality of life. The treatment of tendon HO remains challenging due to a lack of clarity regarding the pathological mechanism. Mohawk (MKX) is a key factor in preventing tendon HO; however, its upstream regulatory mechanism remains to be understood. This study aimed to identify potential compounds that target and regulate MKX and explore their functional mechanisms.

Methods
Bioinformatics analysis of MKX-related compounds and proteins was performed based on data from the STITCH and OncoBinder databases. Subsequently, the SymMap database was used to study MKX-related traditional Chinese medicine drugs and symptoms. Next, the OncoBinder genomic and proteomic discovery model was applied to identify potential regulators of MKX. The analytical tool Expert Protein Analysis System for proteomics was used to predict the three-dimensional structure of MKX, and the AutoDockTools software was used to identify pockets of activity at potential sites for molecular docking. Furthermore, we evaluated the effect of different doses of 17-beta-estradiol on bone marrow-derived mesenchymal stem cells (BM-MSCs).

Results
By predicting the three-dimensional structure of MKX and simulating molecular docking, Pro-Tyr and 17-beta-Estradiol were found to target and bind to MKX. Analysis of the STITCH and OncoBinder databases showed that MKX had a significant regulatory correlation with suppressor interacting 3 A/histone deacetylase 1 (SIN3A/HDAC1). The GO and KEGG pathway enrichment analysis revealed that the functions of MKX and its associated proteins were mainly enriched in osteogenic-related pathways. Assessment of the proliferation of BM-MSCs revealed that 17-beta-estradiol possibly upregulated the mRNA expression of the HDAC1-SIN3A/BMP pathway-related RUNX2, thereby promoting the proliferation of BM-MSCs.

Conclusions
The compounds Pro-Tyr and 17-beta-Estradiol may bind to MKX and thus affect the interaction of MKX with SIN3A/HDAC1.
Practice Of Ophthalmic Self-Medication Among Patients In Central India: Questionnaire Based Study
Authors: Chakrabarty Lipi 
Published: January 2022

Purpose:
To identify and analyze the practice of ocular self-medication in adult patients attending an ophthalmology clinic in central India.

Methods:
A cross sectional, descriptive, questionnaire-based observational study was carried out at Durg, Chhattisgarh, India over a period of eight months from July 2017 to February 2018. The study included 1490 consecutive and consenting adult patients reporting for the first time in a private ophthalmology clinic. Self-medication was defined as the use of ophthalmic medicines used in the past one year without consultation of health care professionals. Responses to a semi-structured questionnaire covering socio-demographic details and various aspects of eye medication usage like duration, source, reason etc. were obtained with a face-to-face interview. The relationship between self-medication and demographic factors was analyzed using chi-square test of association, univariate analysis and multivariable logistic regression.

Results:
432 subjects (29%) reported using ophthalmic medications without consulting an ophthalmologist. Patients used medications commonly for itching of eyes (41%), burning sensation (39%) and watering (38%). The most common used eye drops were ayurvedic and herbal (21%), antibiotics (17%) and antibiotic-steroid combination (10%). Of the patients who self-medicated, majority used medications recommended by pharmacist or relatives and friends. Males (OR: 1.51, p= 0.0007), married subjects (OR: 2.05, p= 0.0001) and rural patients (OR: 1.29, p= 0.046) were more likely to self-medicate. No significant difference was found in self-medication practices according to age (p=0.291) and level of education (p=0.983).

Conclusion:
Arbitrary practice of ophthalmic self-medication is prevailing. This warrants educational efforts, public awareness and regulatory legislations to lessen the consequences.
The Usefulness of Glycated Hemoglobin (HbA1c) in the Detection of Diabetes Mellitus
Authors: Alam Md Fakhrul , Ahmed Jamal Uddin , Jahan Israt , Roy Suvash Chandra 
Published: January 2022

Background: Health conditions like Diabetes mellitus sometimes affects serious to health due to unavailability of accurate check. But with advancements of diagnostics test like glycated hemoglobin (HbA1c) can save many lives to detect Diabetes Mellitus.
Objective: In this study our main goal is to evaluate the accuracy of glycated hemoglobin (HbA1c.) in the diagnosis of Diabetes Mellitus.
Methods: The Tertiary Medical College, Bangladesh, outpatient department (OPD) conducted this cross-sectional study. Where information was gathered between January 2019 and January 2020.
During the research, a total of 100 individuals were enrolled with contemporaneous FPG, OGTT and A1c findings and diabetes mellitus suspicion. Purposive sampling was used to acquire the samples according to the inclusion criteria.
Results: Most of the patients in the research were aged 47 to 57. 30.8% of the population and the majority (60%) were male. 71% of diabetes patients were identified alone by A1c, followed by 66% by 2h OGTT, and 43% of diabetic patients were diagnosed solely by fasting plasma glucose (FPG). IFG was found in 58% of the patients, whereas OGTT found IGT in 20% of the patients, and A1c found IGT in 24% of the patients. The difference between A1c and OGTT in diagnosing glucose intolerance was statistically significant (P 0.0001).
Conclusion: This study's findings support the use of HbA1c as a screening tool for type 2 diabetes. Increasing access to diabetes care in Bangladesh may be made easier by using the HbA1c test, which is less onerous for patients than either FPG or oral glucose tolerance testing.
Determination of Heavy Metal Concentration in Two Bony Fish (Catfish and Tilapia) from Orashi River in Rivers State, Nigeria
Authors: Okwodu N. E. , Okorie P. U. , Nwoke B. E. B. 
Published: January 2022

The research was intended to study the influence of human and industrial activities on the Orashi River and two bony fish (Clarias gariepinus and Tilapia nilotica). Three groups are observed to have impacted the environment – Oil/gas industries, tyre burning from abattoir, untreated human and animal waste from settlers and the abattoir. The study was carried out from September 2019 to August 2020. The mean concentrations of the parameters studied in some samples were close to or exceeded World Health Organization (WHO) and Federal Ministry of Environment (FMEnv) recommended limits for drinking water and seafood. The results from this study have provided information on the heavy metals profile on the fish of the river. The level of heavy metals in the muscle of Catfish and Tilapia showed a range of Cadmium in Catfish (1-3.9mg/kg and Tilapia (0.1-4.2mg/kg) with the highest level occurring in station 2 (3.47mg/kg for Catfish and 3.39mg/kg for Tilapia) which is high with regard to FAO 19835, FAO/WHO 10896, EEC 20054 permissible limit of 0.01mg/l and USEPA SQG (1mg/kg) level in seafood. The levels of essential heavy metals in fish muscle were Copper (Catfish-10.9-33mg/kg, Tilapia -17.3-40.6mg/kg), Iron (Catfish-1.0-2.5mg/kg, Tilapia -0.1-5.6mg/kg) were within the FAO 1983 permissible limit while Zinc (Catfish-22-213.2mg/kg) and Tilapia (30.1-196mg/kg) exceeds the limit in some stations. Catfish muscles recorded higher mean value (127.12mg/kg) for all heavy metals than tilapia (44.03mg/kg) and the sequence is Copper > Zinc > Iron > Cadmium. The concentration of heavy metals in Orashi River is in the sequence: Sediment > Catfish > Tilapia >Water. The Total Heavy metal concentration in muscle of Catfish (0.5-1.8mg/kg) and Tilapia (0.1-3.8mg/kg) were within permissible limit.
Microbial Quality and Aflatoxin Levels of Bread and Flour Products Vended in Akure Metropolis, Ondo State, Nigeria
Authors: Onifade Anthony Kayode , Akande Margaret Olaide 
Published: January 2022

Aim: This study evaluated the microbial quality characteristics of bread and flour-made products vended for human consummation in Akure metropolis.
Methods: The sample products including bread, buns, puff puff, meat pie and cake collected from different locations were analysed using standard microbiological methods to enumerate the bacterial and fungal consortia. Macro and micro-morphological identification of the implicated fungi in the food samples were done via standard techniques. The presence and quantity of some aflatoxin types were also investigated using standard techniques.
Results: The fungal organisms enumerated include species of Fusarium, Aspergillus, Cladosporium, Mucor, Sacharomyces cerevisiae, Rhizopus and Penicillium. Bacteria consortium implicated in sample products include; Staphylococcus aureus, Bacillus sp., Escherichia coli, Clostridium sp., Pseudomonas aeruginosa and the likes. The levels of aflatoxin B1 and B2 produced were predominantly associated with Aspergillus flavus enumerated from bread products which serve as a rider to the aflatoxin contamination in vended flour products.
Conclusion: The toxicity and potency of aflatoxins make them a primary health hazard and as well accountable for losses associated with contamination of processed foods and ready-to-eat foods. It is recommended that bakers should implement the use of heat-treated flour in the production process of ready-to-eat products for human safety.
Assessment of Nutritional Properties from Six Varieties of Onion (Allium cepa L., Alliaceae) Produced in Northern Côte d’Ivoire
Authors: Ysidor Konan N’guessan , Nafan Diarrassouba , Zadjéhi Koffi Eric-Blanchard , Martial Yao Saraka Didier , Koulotioloma Soro , Mohamed Cisse , Marius Biego Godi Henri 
Published: January 2022

Aims: Onion is a common vegetable engaging significant nutritional interests and widely consumed over the world. In Côte d'Ivoire, 95% of the onion consumption is filled by imports despite the availability of suitable areas for its local production. The current study aimed to investigate nutritional features of onion varieties for fitting the agronomical trends in order to strengthen the onion cultivation in northern Côte d’Ivoire.
Study Design: Six onion varieties produced for bulbs, namely ARES, BATI, CARA, DAMANI, KARIBOU, and SAFARI. Onion bulbs sampled, oven-dried, and then processed to powders for analysis. The main study consisted in analyzing the biochemical properties of the resulted onions powders.
Place and Duration of Study: Experimental farming from the plants experimenting location, and onion samples analyzed from Laboratory of Peleforo Gon Coulibaly University, Korhogo, Côte d’Ivoire, between March 2020 and April 2021.
Methodology: Batches of 2 kg fresh bulbs collected per onion variety after harvest. Once at Lab, onion bulbs peeled, washed, cut into small dice-shaped pieces and dried into an oven at 80 °C for 24 h using stainless trays. Dried samples ground and kept for analyses regarding physicochemical traits (moisture, acidity, ash) and nutritive parameters (glucides, lipids, proteins, antioxidants).
Results: The works showed higher contents in moisture (16.91%), ash (4.46%), and lipids (1.99%) from CARA variety with more significant acidity; while greatest amounts of total soluble carbohydrates (14.5%), tannins (1.02%), and proteins (13.6%) were recorded from BATI and more vitamin C in DAMANI (0.133%). However, SAFARI variety samples were more provided in reducing carbohydrates (1.04%) and total polyphenols (1.46%) as secondary metabolites; and the ARES variety revealed highest flavonoids contents (0.057%). In addition, ARES, CARA, and KARIBOU varieties displayed great dietary fibers amounts compared to BATI, KARIBOU, and SAFARI.
Conclusion: The particular nutritional traits of the studied onion varieties could be confronted with their agronomical yield and consumption trends for supporting sustainable production of onion in Côte d’Ivoire.
Polarized Hydroxyapatite: New Insights and Future Perspectives Through Systematic Electrical Characterization at the Interface
Authors: Sans Jordi , Arnau Marc , Sanz Vanesa , Turon Pau , Alemán Carlos 
Published: January 2022

AbstractDesign of hydroxyapatite (HAp) with customized electrical properties is of special interest for developing technological and biomedical applications with new improved functionalities. Polarized HAp, which is obtained by applying an external electric voltage at high temperature, has been successfully shown to be an alternative to doped‐HAp that is limited by the biocompatibility of the dopants used. However, many aspects about such new material remain scarcely studied, as for example the relationship between the polarization conditions and the resultant electrical enhancement, hinder a solid progress in its application. In this work, polarized HAp has been extensively characterized using electrochemical impedance spectroscopy by means of proposing a unified electrical equivalent circuit model with physical sense. This allows to explain the properties of such material by separating the bulk and the interface contributions. Moreover, the limits of the polarization mechanism have been explored, enabling a precise control on the electrical resistivity of polarized HAp above or below the intrinsic resistivity of nonpolarized HAp. Overall, necessary insights on the polarization treatment have been reported, opening an appealing avenue for generating new biomedical and technological applications based on dopant‐free polarized HAp.