bluuebunny/crossref_metadata_2025_split huggingface dataset:
Richard Pynson’s Property in St Clement Danes, 1491–1500
Authors: Payne M T W 
Published: March 2022

Abstract
This bibliographical note explores a previously unknown lease to the printer Richard Pynson by the Knights of St John of property in St Clement Danes, to the west of the City of London, in 1495. As well as providing further evidence for the location of Pynson’s first press, it also suggests that the date of his first lease of the same property, and hence of his setting up of one of the earliest printing presses in London, was during the summer of 1491.
Kinematic footprint of the Milky Way spiral arms in Gaia EDR3
Authors: Martinez-Medina Luis , Pérez-Villegas Angeles , Peimbert Antonio 
Published: March 2022

ABSTRACT
The Milky Way spiral arms are well established from star counts as well as from the locus of molecular clouds and other young objects; however, they have only recently started to be observed from a kinematics point of view. Using the kinematics of thin disc stars in Gaia EDR3 around the extended solar neighbourhood, we create x–y projections coloured by the radial, residual rotational, and vertical Galactocentric velocities (U, ΔV, W). The maps are rich in substructures and reveal the perturbed state of the Galactic disc. We find that local differences between rotational velocity and the azimuthally averaged velocity, ΔV, display at least five large-scale kinematic spirals; two of them closely follow the locus of the Sagittarius-Carina and Perseus spiral arms, with pitch angles of 9.12° and 7.76°, and vertical thickness of ∼400 pc and ∼600 pc, respectively. Another kinematic spiral is located behind the Perseus arm and appears as a distortion in rotation velocities left by this massive arm but with no known counterpart in gas or stars overdensity. A weaker signal close to the Sun’s position is present in our three velocity maps, and appears to be associated with the Local arm. Our analysis of the stellar velocities in the Galactic disc shows kinematic differences between arms and interarms that are in favour of Milky Way spiral arms that do not corotate with the disc. Moreover, we show that the kinematic spirals are clumpy and flocculent, revealing the underlying nature of the Milky Way spiral arms.
Cold and hot gas distribution around the Milky-Way – M31 system in the HESTIA simulations
Authors: Damle Mitali , Sparre Martin , Richter Philipp , Hani Maan H , Nuza Sebastián E , Pfrommer Christoph , Grand Robert J J , Hoffman Yehuda , Libeskind Noam , Sorce Jenny G , Steinmetz Matthias , Tempel Elmo , Vogelsberger Mark , Wang Peng 
Published: March 2022

ABSTRACTRecent observations have revealed remarkable insights into the gas reservoir in the circumgalactic medium (CGM) of galaxy haloes. In this paper, we characterize the gas in the vicinity of Milky Way and Andromeda analogues in the hestia (High resolution Environmental Simulations of The Immediate Area) suite of constrained Local Group (LG) simulations. The hestia suite comprise of a set of three high-resolution arepo-based simulations of the LG, run using the Auriga galaxy formation model. For this paper, we focus only on the z = 0 simulation data sets and generate mock skymaps along with a power spectrum analysis to show that the distributions of ions tracing low-temperature gas (H i and Si iii) are more clumpy in comparison to warmer gas tracers (O vi, O vii, and O viii). We compare to the spectroscopic CGM observations of M31 and low-redshift galaxies. hestia underproduces the column densities of the M31 observations, but the simulations are consistent with the observations of low-redshift galaxies. A possible explanation for these findings is that the spectroscopic observations of M31 are contaminated by gas residing in the CGM of the Milky Way.
Major and minor flares on Cygnus X-3 revisited
Authors: Spencer Ralph E , Garrett Michael , Bray Justin D , Green David A 
Published: March 2022

ABSTRACT
Intense flares at cm wavelengths reaching levels of tens of Jy have been observed from Cygnus X-3 for many years. This active high-mass X-ray binary also has periods of quenching before major outbursts, and has minor flares at levels of a few hundred mJy. In this paper, we show that the minor flares have much shorter rise times and durations suggesting more rapid expansion of the synchrotron radiation emitting material than in the strong flares. They also appear closer to the binary, whereas the large flares form a more developed jet. Calculations of physical conditions show that the minor outbursts have lower minimum power but have larger magnetic fields and energy densities than the major flares. Minor flares can occur while a major flare is in progress, suggesting an indirect coupling between them. The spectral evolution of the minor flares can be explained by either an expanding synchrotron source or a shock model. The possibility that there is a brightening zone as in SS433 is explored.
Host galaxies and electromagnetic counterparts to binary neutron star mergers across the cosmic time: detectability of GW170817-like events
Authors: Perna Rosalba , Artale M Celeste , Wang Yi-Han , Mapelli Michela , Lazzati Davide , Sgalletta Cecilia , Santoliquido Filippo 
Published: March 2022

ABSTRACT
The association of GRB170817A with a binary neutron star (BNS) merger has revealed that BNSs produce at least a fraction of short gamma-ray bursts (SGRBs). As gravitational wave (GW) detectors push their horizons, it is important to assess coupled electromagnetic (EM)/GW probabilities and maximize observational prospects. Here, we perform BNS population synthesis calculations with the code mobse, seeding the binaries in galaxies at three representative redshifts, $z$ = 0.01, 0.1, and 1 of the Illustris TNG50 simulation. The binaries are evolved and their locations numerically tracked in the host galactic potentials until merger. Adopting the microphysics parameters of GRB170817A, we numerically compute the broad-band light curves of jets from BNS mergers, with the afterglow brightness dependent on the local medium density at the merger site. We perform Monte Carlo simulations of the resulting EM population assuming either a random viewing angle with respect to the jet, or a jet aligned with the orbital angular momentum of the binary, which biases the viewing angle probability for GW-triggered events. We find a gamma-ray detection probability of $\sim\!2{{\rm per\ cent}},10{{\rm per\ cent}},\mathrm{and}\ 40{{\rm per\ cent}}$ for BNSs at $z$ = 1, 0.1, and 0.01, respectively, for the random case, rising to $\sim\!75{{\rm per\ cent}}$ for the $z$ = 0.01, GW-triggered aligned case. Afterglow detection probabilities of GW-triggered BNS mergers vary in the range of $\sim \! 0.3 \!-\! 0.5{{\rm per\ cent}}$, with higher values for aligned jets, and are comparable across the high- and low-energy bands, unlike gamma-ray-triggered events (cosmological SGRBs) which are significantly brighter at higher energies. We further quantify observational biases with respect to host galaxy masses.
Oxidative stress-CBP axis modulates MOB1 acetylation and activates the Hippo signaling pathway
Authors: Jin Jiaqi , Zhang Lei , Li Xueying , Xu Weizhi , Yang Siyuan , Song Jiagui , Zhang Wenhao , Zhan Jun , Luo Jianyuan , Zhang Hongquan 
Published: March 2022

Abstract
Reactive oxygen species (ROS) are constantly produced in cells, an excess of which causes oxidative stress. ROS has been linked to regulation of the Hippo pathway; however, the underlying detailed mechanisms remain unclear. Here, we report that MOB1, a substrate of MST1/2 and co-activator of LATS1/2 in the canonical Hippo pathway, interacts with and is acetylated at lysine 11 by acetyltransferase CBP and deacetylated by HDAC6. MOB1-K11 acetylation stabilizes itself by reducing its binding capacity with E3 ligase Praja2 and subsequent ubiquitination. MOB1-K11 acetylation increases its phosphorylation and activates LATS1. Importantly, upstream oxidative stress signals promote MOB1 acetylation by suppressing CBP degradation, independent of MST1/2 kinase activity and HDAC6 deacetylation effect, thereby linking oxidative stress to activation of the Hippo pathway. Functionally, the acetylation-deficient mutant MOB1-K11R promotes lung cancer cell proliferation, migration and invasion in vitro and accelerates tumor growth in vivo, compared to the wild-type MOB1. Clinically, acetylated MOB1 corresponds to better prediction of overall survival in patients with non-small cell lung cancer. Therefore, as demonstrated, an oxidative stress-CBP regulatory axis controls MOB1-K11 acetylation and activates LATS1, thereby activating the Hippo pathway and suppressing YAP/TAZ nuclear translocation and tumor progression.
Outcome and Failure Analysis of 132 Episodes of Hematogenous Periprosthetic Joint Infections—A Cohort Study
Authors: Renz Nora , Trampuz Andrej , Perka Carsten , Rakow Anastasia 
Published: March 2022

Abstract

Background
The outcomes of hematogenous periprosthetic joint infection (PJI) and reasons for failure are largely unknown.

Methods
The outcomes of consecutive patients with hematogenous PJI treated at our institution between 2010 and 2019 were evaluated. Failure was classified as persistence or relapse of infection or new infection. Failure-free survival was assessed using Kaplan-Meier analysis. Proportions between groups were compared with the Fisher exact test.

Results
One hundred thirty-two hematogenous PJI episodes involving knee (n = 76), hip (n = 54), shoulder (n = 1), or elbow (n = 1) prostheses experienced by 110 patients were included. The median follow-up (range) was 20.7 (0.2–89.9) months. Hematogenous PJIs were caused by Staphylococcus aureus (n = 49), Streptococcus spp. (n = 36), Enterococcus faecalis (n = 17), Enterobacterales (n = 16), coagulase-negative staphylococci (n = 9), and other (n = 6). Debridement and implant retention were performed in 50 (38%), prosthesis exchange or removal in 79 (60%), and no surgery in 3 episodes (2%). Treatment failed in 42 episodes (32%), including 6 infection-related deaths. Among 36 nonfatal failures, 21 were caused by a new pathogen and 8 by the same pathogen, in 7 episodes no pathogen was isolated. Of all nonfatal failures, 19 (53%) PJIs were of hematogenous origin. Identification of the primary focus, causative pathogen, and CRIME80 Score did not influence treatment outcome, but the failure rate was higher following prosthesis retention compared with multistage exchange.

Conclusions
Persistence-/relapse-free survival after treatment of hematogenous PJI was high (84%). New hematogenous PJI due to the same or a new pathogen occurred frequently, reducing treatment success to 62% after 4 years of follow-up, suggesting an individual predisposition to hematogenous PJI. The outcome was similar for different pathogens but worse in episodes treated with prosthesis retention compared with multistage exchange.
A field evaluation of a matching mechanism: University applicant behavior in Australia
Authors: Guillen Pablo , Kesten Onur , Kiefer Alexander , Melatos Mark 
Published: March 2022

Abstract
The majority of undergraduate university applications in the state of New South Wales—Australia's largest state—are processed by a clearinghouse, the Universities Admissions Centre (UAC). Applicants submit an ordered list of degrees to the UAC, which applies a matching algorithm to allocate university places to eligible applicants. Applicants receive advice on how to construct their degree preference list from multiple sources including individual universities. This advice is often confusing and misleading. To evaluate the performance of the current system, we run a large sample (832 observations) online experiment with experienced participants in a choice environment that mimics the UAC application process, and in which truth telling is optimal. We vary the advice received across treatments: no advice, the UAC advice only, an instance of misleading university advice only, and both the UAC and the misleading university advice together. Overall, 75.5% of participants fail to behave in their best interest. High rates of applicant manipulation persist even when applicants are provided with the UAC's accurate advice. Students who attend nonselective government high schools are more prone to use strictly dominated strategies than those who attend academically selective government high schools and private high schools.
The Processing of Semantic Complexity and Cospeech Gestures in Schizophrenia: A Naturalistic, Multimodal fMRI Study
Authors: Cuevas Paulina , He Yifei , Steines Miriam , Straube Benjamin 
Published: March 2022

Abstract
Schizophrenia is marked by aberrant processing of complex speech and gesture, which may contribute functionally to its impaired social communication. To date, extant neuroscientific studies of schizophrenia have largely investigated dysfunctional speech and gesture in isolation, and no prior research has examined how the two communicative channels may interact in more natural contexts. Here, we tested if patients with schizophrenia show aberrant neural processing of semantically complex story segments, and if speech-associated gestures (co-speech gestures) might modulate this effect. In a functional MRI study, we presented to 34 participants (16 patients and 18 matched-controls) an ecologically-valid retelling of a continuous story, performed via speech and spontaneous gestures. We split the entire story into ten-word segments, and measured the semantic complexity for each segment with idea density, a linguistic measure that is commonly used clinically to evaluate aberrant language dysfunction at the semantic level. Per segment, the presence of numbers of gestures varied (n = 0, 1, +2). Our results suggest that, in comparison to controls, patients showed reduced activation for more complex segments in the bilateral middle frontal and inferior parietal regions. Importantly, this neural aberrance was normalized in segments presented with gestures. Thus, for the first time with a naturalistic multimodal stimulation paradigm, we show that gestures reduced group differences when processing a natural story, probably by facilitating the processing of semantically complex segments of the story in schizophrenia.
Is renewable energy more favorable to diversity than conventional energy sources on R&D performance?
Authors: Kim Dohyoung , Hwang Junseok 
Published: March 2022

AbstractDiversity is often key to solving challenging problems. It sparks creativity through embracing various perspectives. Energy transition and climate change are challenges that require significant creativity and innovative ideas. This study is designed to analyze if diversity in the workforce has a meaningful relation to research and development (R&D) performance of public renewable energy in South Korea, and possibly, to compare the diversity of the workforce and its relation to performance between power generation industries. Using 538 public R&D projects, this study analyzed intellectual and economic performance along with workforce diversity based on gender, age, educational background, and educational level. Among several findings in this study, this study found a positive relationship between gender diversity and intellectual performance but a negative relationship between age diversity and intellectual performance. In addition, a clear distinction was found between renewable energy and nuclear and thermal power in terms of the research workforce itself and its relation to performance.
Stroke-Induced Neurological Dysfunction in Aged Mice Is Attenuated by Preconditioning with Young Sca-1+ Stem Cells
Authors: Wlodarek Lukasz , Alibhai Faisal J , Wu Jun , Li Shu-Hong , Li Ren-Ke 
Published: March 2022

Abstract

Aims
To date, stroke remains one of the leading causes of death and disability worldwide. Nearly three-quarters of all strokes occur in the elderly (&gt;65 years old), and a vast majority of these individuals develop debilitating cognitive impairments that can later progress into dementia. Currently, there are no therapies capable of reversing the cognitive complications which arise following a stroke. Instead, current treatment options focus on preventing secondary injuries, as opposed to improving functional recovery.

Methods
We reconstituted aged (20-month old) mice with Sca-1+ bone marrow (BM) hematopoietic stem cells isolated from aged or young (2-month old) EGFP+ donor mice. Three months later the chimeric aged mice underwent cerebral ischemia/reperfusion by bilateral common carotid artery occlusion (BCCAO), after which cognitive function was evaluated. Immunohistochemical analysis was performed to evaluate host and recipient cells in the brain following BCCAO.

Results
Young Sca-1+ cells migrate to the aged brain and give rise to beneficial microglial-like cells that ameliorate stroke-induced loss of cognitive function on tasks targeting the hippocampus and cerebellum. We also found that young Sca-1+ cell-derived microglial-like cells possess neuroprotective properties as they do not undergo microgliosis upon migrating to the ischemic hippocampus, whereas the cells originating from old Sca-1+ cells proliferate extensively and skew toward a pro-inflammatory phenotype following injury.

Conclusions
This study provides a proof-of-principle demonstrating that young BM Sca-1+ cells play a pivotal role in reversing stroke-induced cognitive impairments and protect the aged brain against secondary injury by attenuating the host cell response to injury.
The Effect of Work on Antisocial Behavior among Formerly Incarcerated Young Adults: A Panel Analysis
Authors: Lee Lewis H , Kim Minseop 
Published: March 2022

Abstract
Although there is ample research on the association between employment and adults’ crime, few studies have focused on formerly incarcerated juveniles transitioning to emerging adults, especially studies using panel data. Using data from the Pathways to Desistance Study (N = 1,289) with a group of high-risk emerging adults (ages 18 to 24), this panel analysis addresses the effect of employment on antisocial behavior guided by Laub and Sampson’s social bond theory. The results show average weeks worked for the sample is below 26 weeks per year at each time point, indicating low levels of labor market participation. A fixed effects model using a structural equation modeling approach confirms that those with more work are significantly likely to decrease antisocial behavior. Consistent with previous studies, individuals with more substance use and gang involvement are positively associated with antisocial behavior. The article concludes with a discussion of the role of employment and emerging adults.
Universal Accessible Biomarkers of Drug-Induced Tissue Injury and Systemic Inflammation in Rat: Performance Assessment of TIMP-1, A2M, AGP, NGAL, and Albumin
Authors: Vlasakova Katerina , Bourque Jennifer , Bailey Wendy J , Patel Shetal , Besteman Elizabeth G , Gonzalez Raymond J , Sistare Frank D , Glaab Warren E 
Published: March 2022

Abstract
The ability to monitor for general drug-induced tissue injury (DITI) or systemic inflammation in any tissue using blood-based accessible biomarkers would provide a valuable tool in early exploratory animal studies to understand potential drug liabilities. Here we describe the evaluation of 4 biomarkers of tissue remodeling and inflammation (α2-macroglobulin [A2M], α1-acid glycoprotein [AGP], neutrophil gelatinase-associated lipocalin [NGAL], and tissue inhibitor of metalloproteinases [TIMP-1]) as well as the traditional serum parameter albumin as potential blood-based biomarkers of DITI and systemic inflammatory response (SIR). Biomarker performance was assessed in 51 short-term rat in vivo studies with various end-organ toxicities or SIR and receiver operating characteristic curves were generated to compare relative performances. All 4 biomarkers performed well in their ability to detect DITI and SIR with an area under the curve (AUC) of 0.82–0.78, however TIMP-1 achieved the best sensitivity (at 95% specificity) of 61%; AGP, NGAL, and A2M sensitivity was 51%–52%. AUC for albumin was 0.72 with sensitivity of 39%. A2M was the best performer in studies with only SIR (AUC 0.91). In the subset of studies with drug-induced vascular injury, TIMP-1 performed best with an AUC of 0.96. Poor performance of all tested biomarkers was observed in samples with CNS toxicity. In summary, TIMP-1, A2M, AGP, and NGAL demonstrated performance as sensitive accessible biomarkers of DITI and SIR, supporting their potential application as universal accessible tissue toxicity biomarkers to quickly identify dose levels associated with drug-induced injury in early exploratory rat safety and other studies.
Virtual Compared With In-Clinic Transvaginal Ultrasonography for Ovarian Reserve Assessment
Authors: Chung Esther H. , Petishnok Laura C. , Conyers Jesse M. , Schimer David A. , Vitek Wendy S. , Harris Amy L. , Brown Michelle A. , Jolin Julie A. , Karmon Anatte , Styer Aaron K. 
Published: March 2022

OBJECTIVE:
To evaluate noninferiority of virtual transvaginal ultrasonography compared with in-clinic ultrasonography for ovarian reserve assessment.

METHODS:
We conducted a single-site, head-to-head crossover trial. Participants performed self-administered virtual transvaginal ultrasonography at home, guided by a remote-certified ultrasound technologist, then underwent transvaginal ultrasonography in-clinic with another ultrasound technologist. Participants were women in the greater Boston area interested in evaluating ovarian reserve and recruited through social media, health care referrals, and professional networks. The uterus and ovaries were captured in sagittal and transverse views. These randomized recordings were reviewed by two or three independent, blinded reproductive endocrinologists. The primary outcome was noninferiority of the rate of clinical quality imaging produced at home compared with in clinic. Sample size was selected for greater than 90% power, given the 18% noninferiority margin. Secondary outcomes included antral follicle count equivalency and net promoter score superiority.

RESULTS:
Fifty-six women were enrolled from December 2020 to May 2021. Participants varied in age (19–35 years), BMI (19.5–33.9), and occupation. Ninety-six percent of virtual and 98% of in-clinic images met “clinical quality.” The difference of −2.4% (97.5% CI lower bound −5.5%) was within the noninferiority margin (18%). Antral follicle counts were equivalent across settings, with a difference in follicles (0.23, 95% CI −0.36 to 0.82) within the equivalence margin (2.65). Virtual examinations had superior net promoter scores (58.1 points, 97.5% CI of difference 37.3–79.0, P<.01), indicating greater satisfaction with the virtual experience.

CONCLUSION:
Virtual transvaginal ultrasonography remotely guided by an ultrasonography technologist is noninferior to in-clinic transvaginal ultrasonography for producing clinical quality images and is equivalent for estimating antral follicle count. Virtual transvaginal ultrasonography had superior patient satisfaction and has potential to significantly expand patient access to fertility care.

FUNDING SOURCE:
This study was sponsored by Turtle Health.

CLINICAL TRIAL REGISTRATION:
ClinicalTrials.gov, NCT04687189.