bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Effect of Anti‐Scl‐70 Antibody Determination Method on Its Predictive Significance for Interstitial Lung Disease Progression in Systemic Sclerosis
Authors: Jandali Bochra , Salazar Gloria A. , Hudson Marie , Fritzler Marvin J. , Lyons Marka A. , Estrada‐Y‐Martin Rosa M. , Charles Julio , Terracina Katherine A. , Mayes Maureen D. , Assassi Shervin 
Published: January 2022

ObjectiveThe objective of this study was to assess the predictive significance of anti‐Scl‐70 (anti‐topoisomerase I) antibodies, as determined by three different methods, for decline in forced vital capacity (FVC) within the first year of follow‐up in patients with systemic sclerosis (SSc)‐related interstitial lung disease (ILD).MethodsPatients in the Genetics Versus Environment in Scleroderma Outcome Study cohort who had ILD (verified by imaging) and available FVC% at enrollment, plus 12 to 18 months thereafter, were examined. All patients had a disease duration of 5 years or less at enrollment. The annualized percentage change in FVC% at 1 year follow‐up was the outcome variable. Anti‐Scl‐70 antibodies were determined by passive immunodiffusion (ID) against calf thymus extract, chemiluminescent immunoassay (CIA), and line blot immunoassay (LIA).ResultsNinety‐one patients with a mean disease duration of 2.36 years were included. Anti‐Scl‐70 antibodies by ID predicted a faster rate of FVC% decline (b = −0.06, P = 0.04). None of the other clinical or serological variables significantly predicted ILD progression. Interestingly, anti‐Scl‐70 antibodies as determined by CIA and LIA were not significant predictors of FVC decline (P = 0.26 and 0.64, respectively). The observed level of agreement between ID and LIA was moderate (κ = 0.568), whereas it was good between ID and CIA (κ = 0.66).ConclusionAnti‐Scl‐70 antibodies determined by ID predicted faster FVC decline in patients with SSc‐related ILD. Notably, both CIA and LIA for the same antibody did not predict rate of FVC decline at their current cutoffs of positivity. The discrepancy observed between anti‐Scl‐70 antibody assays can have relevant implications for clinical care and trial enrichment strategies in SSc‐ILD.
Bioinspired Perovskite Nanocrystals‐Integrated Photonic Crystal Microsphere Arrays for Information Security
Authors: Bian Feika , Sun Lingyu , Chen Hanxu , Wang Yu , Wang Li , Shang Luoran , Zhao Yuanjin 
Published: January 2022

AbstractInformation security occupies an important position in the era of big data. Attempts to improve the security performance tend to impart them with more additional encryption strategies. Herein, inspired by the wettability feature of Stenocara beetle elytra and signal model of traffic light, a novel array of perovskite nanocrystals (PNs)‐integrated PhC microsphere for information security is presented. The photoluminescent PNs are encapsulated in angle‐independent PhC microspheres to impart them with binary optical signals as coding information. Through the multimask superposition approach, PNs‐integrated PhC microspheres with different codes are placed into fluorosilane‐treated PDMS substrate to form different arrays. These arrays could converge moisture on PhC microspheres in wet environment, which avoids the ions loss of the PNs and effectively prevented mutual contamination. In addition, the fluorescence of the PNs inside PhC microspheres could reversibly quench or recover in response to the environmental moisture. Based on these features, it is demonstrated that the PNs‐integrated PhC microsphere arrays could realize various information encryption modes, which indicate their excellent values in information security fields.
Engineering a Rapid Insulin Release System Controlled By Oral Drug Administration
Authors: Mahameed Mohamed , Xue Shuai , Stefanov Bozhidar‐Adrian , Hamri Ghislaine Charpin‐El , Fussenegger Martin 
Published: January 2022

AbstractRapid insulin release plays an essential role in maintaining blood‐glucose homeostasis in mammalians. Patients diagnosed with type‐I diabetes mellitus experience chronic and remarkably high blood‐sugar levels, and require lifelong insulin injection therapy, so there is a need for more convenient and less invasive insulin delivery systems to increase patients’ compliance and also to enhance their quality of life. Here, an endoplasmic‐reticulum‐localized split sec‐tobacco etch virus protease (TEVp)‐based rapamycin‐actuated protein‐induction device (RAPID) is engineered, which is composed of the rapamycin‐inducible dimerization domains FK506 binding protein (FKBP) and FKBP‐rapamycin binding protein fused with modified split sec‐TEVp components. Insulin accumulation inside the endoplasmic reticulum (ER) is achieved through tagging its C‐terminus with KDEL, an ER‐retention signal, spaced by a TEVp cleavage site. In the presence of rapamycin, the split sec‐TEVp‐based RAPID components dimerize, regain their proteolytic activity, and remove the KDEL retention signal from insulin. This leads to rapid secretion of accumulated insulin from cells within few minutes. Using liver hydrodynamic transfection methodology, it is shown that RAPID quickly restores glucose homeostasis in type‐1‐diabetic (T1DM) mice treated with an oral dose of clinically licensed rapamycin. This rapid‐release technology may become the foundation for other cell‐based therapies requiring instantaneous biopharmaceutical availability.
Controlling the aggregation and assembly of boron‐containing molecular and polymeric materials
Authors: Shimoyama Daisuke , Jäkle Frieder 
Published: January 2022

AbstractBoron‐containing molecules and polymers are attractive as powerful tunable Lewis acids for small molecule activation and catalysis, as luminescent materials for organic electronic device and (bio)imaging applications, and as smart chemical sensors. While the characteristics of the boron‐containing building blocks are attractive in and of themselves, their assembly into higher order supramolecular materials offers access to unique properties and emerging functions. Herein, we highlight recent achievements in the field of aggregated organoboron materials. We discuss how supramolecular interactions can be exploited to precisely control the structure of the assemblies and impact their functions as luminescent materials, recyclable and smart catalyst systems, chemical sensors, stimuli‐responsive and self‐healing materials.
Aggregation and luminescence in carbonized polymer dots
Authors: Kang Chunyuan , Tao Songyuan , Yang Fan , Yang Bai 
Published: January 2022

AbstractThe aggregate luminescence behavior of organic luminescent materials has been studied extensively. As a new kind of luminescent nanomaterials, carbonized polymer dots (CPDs) not only inherit the stability and biocompatibility of carbon materials, but also possess the luminescence tunability, water solubility, and high photoluminescence quantum yield of organic luminescent materials, rendering them a strong candidate for the next generation of light‐emitting materials. Previously, people mainly understood its luminescence from the perspective of carbon materials, but some luminescence mechanisms are still unclear. In this review, we discuss the luminescence mechanism by referring to organic luminescent materials with emphasis on their aggregation behavior. Firstly, three representative aggregate luminescence phenomena of organic luminescent materials are briefly introduced. Chromophores present in CPDs are elaborated to further discuss the potential interactions between them, with emphasis on the role of crosslinked polymer networks. On this basis, some special luminescence phenomena of CPDs in the aggregate state are summarized, and relevant mechanisms are discussed in detail to consolidate relevant statements.
Rational Design of High‐Performance Nickel‐Sulfur Nanocomposites by the Electroless Plating Method for Electrochemical Lithium‐Sulfur Battery Cathodes
Authors: Cheng Cun‐Sheng , Chung Sheng‐Heng 
Published: January 2022

AbstractThe development of high‐performance sulfur‐based composite cathodes is a promising strategy to accelerate the reaction kinetics of sulfur and decelerate the irreversible loss of polysulfides. Herein, a strategy for fabricating high‐performance metal‐sulfur composite cathodes is proposed to achieve a facile synthesis process, adjustable high sulfur content, and excellent electrochemical performance. Electroless nickel plating is applied to achieve a nickel‐sulfur nanocomposite with metallic nickel to inhibit the high resistance of the active solid‐state materials (i. e., sulfur and lithium sulfide) and the rapid diffusion of the active liquid‐state materials (i. e., lithium polysulfides). Therefore, the electroless nickel‐plated sulfur (ENS) composite cathode attains high, tunable sulfur contents of 60 wt %–95 wt %, large sulfur loadings of 2–10 mg cm−2, and excellent charge‐storage capacity values of 822–1,362 mAh g−1, corresponding to high areal capacity and energy density values of 8.2 mAh cm−2 and 17.3 mWh cm−2, respectively.
Identification of ginsenoside metabolites in plasma related to different bioactivities of Panax notoginseng and Panax ginseng
Authors: Dong Qinghai , An Yang , Du Guangguang , Wang Jia , Liu Jiayin , Su Jun , Xie Hongliu , Liang Chongyang , Liu Jihua 
Published: January 2022

AbstractAlthough the chemical components of Panax notoginseng (PN) and Panax ginseng (PG) are similar, their bioactivities are different. In this study, the differential bioactivities of PN and PG were used as the research object. First, the different metabolites in the plasma after oral administration of PN and PG were analyzed using a UPLC‐Q/TOF‐MS‐based metabolomics approach. Afterward, the metabolite‐target‐ pathway network of PN and PG was constructed, and thus the pathways related to different bioactivities were analyzed. As a result, 7 different metabolites were identified in PN group, and 10 different metabolites were identified in the PG group. In the PN group, the metabolite N1 was related to hemostasis, N1 and N3 were related to inhibiting the nerve center, antihypertensive, and abirritation. The metabolites N1, N3, N4, N5, and N6 were related to liver protection. The results showed that the metabolites G1, G2, G3, G5, and G6 in PG group were related to heart protection, and G1, G2, G6, and G9 were related to increased blood pressure. There were 13 signaling pathways related to different biological activities of PN (8 pathways) and PG (5 pathways). These pathways further clarified the mechanism of action that caused the different bioactivities between PN and PG. In summary, metabolomics combined with network pharmacology could be helpful to clarify the material basis of different bioactivities between PN and PG, promoting the research on PN and PG.
Efficient Oligomerization of Aromatic Amino Acids Induced by Gaps in Four‐Helix Bundles of DNA or RNA
Authors: Doppleb Olivia , Schwarz Rainer Joachim , Landa Maria , Richert Clemens 
Published: January 2022

AbstractThe formation of peptides from amino acids is one of the processes associated with life. Because of the dominant role of translation in extant biology, peptide‐forming processes that are RNA induced are of particular interest. We have previously reported the formation of phosphoramidate‐linked peptido RNAs as the products of spontaneous condensation reactions between ribonucleotides and free amino acids in aqueous solution. We now asked whether four‐helix bundle (4HB) DNA or RNA folding motifs with a single‐ or double‐nucleotide gap next to a 5’‐phosphate can act as reaction sites for phosphoramidate formation. For glycine, this was found to be the case, whereas phenylalanine and tryptophan showed accelerated formation of peptides without a covalent link to the nucleic acid. Free peptides with up to 11 tryptophan or phenylalanine residues were found in precipitates forming in the presence of gap‐containing DNA or RNA 4HBs. Control experiments using motifs with just a nick or primer alone did not have the same effect. Because folded structures with a gap in a double helix are likely products of hybridization of strands formed in statistically controlled oligomerization reactions, our results are interesting in the context of prebiotic scenarios. Independent of a putative role in evolution, our findings suggest that for some aromatic amino acids an RNA‐induced pathway for oligomerization exists that does not have a discernable link to translation.
Synthesis of α‐D‐Ribose 1‐Phosphate and 2‐Deoxy‐α‐D‐Ribose 1‐Phosphate Via Enzymatic Phosphorolysis of 7‐Methylguanosine and 7‐Methyldeoxyguanosine
Authors: Varizhuk Irina V. , Oslovsky Vladimir E. , Solyev Pavel N. , Drenichev Mikhail S. , Mikhailov Sergey N. 
Published: January 2022

AbstractA simple and efficient method for the preparation of α‐D‐ribose 1‐phosphate and 2‐deoxy‐α‐D‐ribose 1‐phosphate, key intermediates in nucleoside metabolism and important starting compounds for the enzymatic synthesis of various modified nucleosides, has been proposed. It consists in near‐irreversible enzymatic phosphorolysis of readily prepared hydroiodide salts of 7‐methylguanosine and 7‐methyl‐2′‐deoxyguanosine, respectively, in the presence of purine nucleoside phosphorylase. α‐D‐Ribose 1‐phosphate and 2‐deoxy‐α‐D‐ribose 1‐phosphate are obtained in near quantitative yields (by HPLC analysis) and 74%‐94% yields after their isolation and purification. © 2022 Wiley Periodicals LLC.Basic Protocol 1: Preparation of α‐D‐ribose 1‐phosphate barium salt (4a)Alternate Protocol 1: Preparation of 2‐deoxy‐α‐D‐ribose 1‐phosphate barium salt (4b)Basic Protocol 2: Preparation of α‐D‐ribose 1‐phosphate bis(cyclohexylammonium) salt (5a)Alternate Protocol 2: Preparation of 2‐deoxy‐α‐D‐ribose 1‐phosphate bis(cyclohexylammonium) salt (5b)
Evaluation of lodging resistance in rice based on an optimized parameter from lodging index
Authors: Luo Xiaoyun , Wu Zefang , Fu Lu , Dan Zhiwu , Yuan Zhengqing , Liang Ting , Zhu Renshan , Hu Zhongli , Wu Xianting 
Published: January 2022

AbstractLodging is being increasingly recognized as a critical concern among crop breeders worldwide as it causes a significant reduction in the grain yield and quality of multiple cereal crops. The lodging index is frequently used for evaluating the lodging resistance of rice (Oryza sativa L.) crops. However, the application of lodging index for comparing lodging susceptibility between different rice cultivars is inadequate under certain special conditions. This study was aimed to identify optimized parameters that would evaluate the lodging susceptibility and could then be used along with the lodging index for further assessing the lodging resistance. A total of 32 representative rice accessions from different countries were grown at two different locations on three different sowing dates over a period of 3 yr. The analysis of the lodging index of the different rice cultivars revealed the lodging index value of 200 as the critical threshold value of the evaluated rice accessions. Subsequently, an optimized parameter from the lodging index was proposed. This parameter could be interpreted as the magnitude of the external force that the basal second internode could withstand. A comparison of the optimized parameter values of different rice accessions revealed a previously unknown lodging‐resistant variety R379. The application of the optimized parameter would enable an accurate determination and comparison of the lodging resistance among different rice cultivars, thereby contributing to the effective selection of lodging‐resistant cultivars in rice breeding programs.
Multidimensional corporate social responsibility disclosure and financial performance: A meta‐analytical review
Authors: Gupta Jyotirani , Das Niladri 
Published: January 2022

AbstractThe emergence of various Corporate Social Responsibility (CSR) disclosure laws around the globe, in the past decade, indicates the significance of CSR for a country as well as for an organization. Organization belief CSR as a strategic tool for enhancing value, still evidence on how CSR disclosure affects financial performance has been inconclusive. To resolve the ambiguity presence in the literature, this study carried out a meta‐analytic investigation based on 168 effect sizes from 73 empirical studies. This study employs a multivariate framework to explore the potential moderators that leads to conflicting results among the focal relationship of the study. The study discovers that if CSR disclosure strategy and measurement technique are adequately addressed with the help of econometric tools, then the true effect of CSR can be observed. Moreover, implications are drawn for academicians and practitioners interested in exploring the relationship between CSR disclosure and financial performance.
A velocity program using the Kanade–Lucas–Tomasi feature‐tracking algorithm with demonstration for pressure and electroosmosis conditions
Authors: Devasagayam Jasen , Bosma Rick , Collier Christopher M. 
Published: January 2022

AbstractInvestigating microfluidic flow profiles is of interest in the microfluidics field for the determination of various characteristics of a lab‐on‐a‐chip system. Microparticle tracking velocimetry uses computational methods upon recording video footage of microfluidic flow to ultimately visualize motion within a microfluidic system across all frames of a video. Current methods are computationally expensive or require extensive instrumentation. A computational method suited to microparticle tracking applications is the robust Kanade–Lucas–Tomasi (KLT) feature‐tracking algorithm. This work explores a microparticle tracking velocimetry program using the KLT feature‐tracking algorithm. The developed program is demonstrated using pressure‐driven and EOF and compared with the respective mathematical fluid flow models. An electrostatics analysis of EOF conditions is performed in the development of the mathematical using a Poisson's Equation solver. This analysis is used to quantify the zeta potential of the electroosmotic system. Overall, the KLT feature‐tracking algorithm presented in this work proved to be highly reliable and computationally efficient for investigations of pressure‐driven and EOF in a microfluidic system.
Neurite density imaging in amygdala nuclei reveals interindividual differences in neuroticism
Authors: Schlüter Caroline , Fraenz Christoph , Friedrich Patrick , Güntürkün Onur , Genç Erhan 
Published: January 2022

AbstractNeuroticism is known to have significant health implications. While previous research revealed that interindividual differences in the amygdala function are associated with interindividual differences in neuroticism, the impact of the amygdala’s structure and especially microstructure on variations in neuroticism remains unclear. Here, we present the first study using NODDI to examine the association between the in vivo microstructural architecture of the amygdala and neuroticism at the level of neurites. We, therefore, acquired brain images from 221 healthy participants using advanced multi‐shell diffusion‐weighted imaging. Because the amygdala comprises several nuclei, we, moreover, used a high‐resolution T1 image to automatically segment the amygdala into eight different nuclei. Neuroticism and its facets have been assessed using the NEO‐PI‐R. Finally, we associated neuroticism and its facets with the volume and microstructure of the amygdala nuclei. Statistical analysis revealed that lower neurite density in the lateral amygdala nucleus (La) was significantly associated with higher scores in depression, one of the six neuroticism facets. The La is the sensory relay of the amygdala, filtering incoming information based on previous experiences. Reduced neurite density and related changes in the dendritic structure of the La could impair its filtering function. This again might cause harmless sensory information to be misevaluated as threatening and lead to the altered amygdala responsivity as reported in previous studies investigating the functional correlates of neuroticism and neuroticism‐related disorders like depression.
Evaluation of the peripheral blood T and B cell subsets and IRF‐7 variants in adult patients with severe influenza virus infection
Authors: Çalık Başaran Nursel , Tan Çağman , Özışık Lale , Özbek Begüm , İnkaya Ahmet Çağkan , Alp Şehnaz , Ersoy Ebru Ortaç , Ayvaz Deniz Çağdaş , Tezcan İlhan 
Published: January 2022

AbstractBackground and AimsInfluenza virus is one of the leading infections causing death among human being. Despite known risks, primary immune deficiency due to Interferon Regulatory Factor‐7 (IRF7) gene defect was reported as a possible cause of the risk factors for complicated influenza. We aimed to investigate the changes in peripheral T and B cell subsets in adult patients with severe seasonal influenza virus infection and the investigation of variants of IRF7 gene.MethodsIn this study, 32 patients, hospitalized due to influenza infection‐related acute respiratory failure were included.ResultsThe median age of the patients was 76 years (26‐96), and 13/32 (40.6%) were in the intensive care unit. Central memory Th, effector memory Th, TEMRA Th, cytotoxic T lymphocytes (CTL), central memory CTL of the patients were found to be increased, naive CTL were decreased. There was a significant increase in the percentage of effector memory Th, and a decrease in the percentage of naive CTL in patients ≥65 years‐old compared to patients <65 years old (P = .039, and P = .017, respectively). IRF7 gene analysis revealed two different nucleotide changes in three patients; c.535 A > G; p.Lys179Glu (K179E) and c584A > T; p.His195Leu (H195L), located in the fourth exon of the IRF7 gene.DiscussionThe increases in central and effector memory Th, central memory CTL and decrease of naive CTLs may be secondary to the virus infection. K179E (rs1061502) and H195L (rs139709725) variants were not reported to be related with susceptibility to an infection yet. It is conceivable to investigate for novel variants in other genes related to antiviral immunity.
Immune‐mediated inflammatory diseases of the gastrointestinal tract: Beyond Crohn's disease and ulcerative colitis
Authors: Vuyyuru Sudheer K , Kedia Saurabh , Sahu Pabitra , Ahuja Vineet 
Published: January 2022

AbstractImmune‐mediated inflammatory diseases (IMIDs) are a diverse group of complex inflammatory diseases that result from dysregulated immune pathways and can involve any system of the human body. Inflammatory bowel disease (IBD) is one such disease involving the gastrointestinal (GI) system. With high prevalence in the West and increasing incidence in newly industrialized countries, IBD poses a significant burden on health care. IMIDs of the GI system other than IBD can have similar clinical features, causing diagnostic and therapeutic challenges. Although these disorders share a common pathophysiology, the defects can occur anywhere in the complex network of cytokines, inflammatory mediators, and innate and adaptive systems, leading to unregulated inflammation. Precise knowledge about them will help determine the possible targeted therapy. Thus, it is essential to distinguish these disorders from IBD. This review describes various IMIDs of the GI tract that mimic IBD.