bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparative assessment of aortic valve stenosis using two-dimensional, three-dimensional transesophageal echocardiography, computed tomography and cardiac catheterization
Authors: Aripov M. A. , Kali A. S. , Tanaliev N. N. , Musaev A. A. , Rashbaeva G. S. , Dautov T. B. 
Published: January 2022

Aim. To compare effectiveness of ultrasound, radiological and invasive methods for assessing aortic valve (AV) stenosis.Material and methods. This study included 33 patients with AV stenosis. The mean age of the patients was 71,8±6,8 years. All patients underwent standard and three-dimensional echocardiography, computed tomography, and cardiac catheterization.Results. According to two-dimensional echocardiography, the AV area averaged 0,58±0,21 mm2, according to cardiac catheterization — 0,61±0,17 mm2, according to three-dimensional transesophageal echocardiography — 1,13±0,42 mm2, and according to multislice computed tomography 0,88±0,48 mm2. The difference between the values was significant (p<0,05).Conclusion. For routine diagnosis of AV stenosis, two-dimensional echocardiography is the optimal research method. With indications for radical treatment methods, three-dimensional echocardiography or multislice computed tomography should be performed.
Universelle Referenzarchitektur für eine sichere cloudbasierte Automation
Authors: Bartsch Witali , Hübner Michael 
Published: January 2022

In the first of a series of articles, we introduce the term “Symbiotic Security” to denote an ideal architecture where all essential components (e.g. hardware, software or networks) contribute to raising the architectural security bar. The growing importance of cloud computing for secure and resilient automation and its intended independence from hardware to accommodate all platforms have led us to observe a disconnect between well-known cloud service providers and manufacturers of embedded devices or IoT: the unsolved problem of initial enrolment. After elaborating on the root cause of this gulf we present a non-invasiveextension and implementation of a cloud IoT reference architecture for an automated, mutually authenticated and encrypted roll-out of IoT nodes. To also enable automated key management without human intervention, the system refrains from using any static secrets usually employed by the hardware vendors – a longstanding point of criticism. Despite our practical choice of a target platform, the idea itself is uniform across such environments given their inherent similarities.
Brennstoffzellensysteme: die Regelung als zentraler Wegbereiter
Authors: Nguyen Thuc Anh , Neisen Verena , Keller Martin , Konrad Thomas , Abel Dirk 
Published: January 2022

Die Elektromobilität nimmt immer weiter an Fahrt auf und mit ihr rücken Brennstoffzellen als effiziente Energiewandler für Nutz- und Personenfahrzeuge in den Fokus, da diese einen emissionsfreien Betrieb mit langen Reichweiten und kurzen Tankzeitenversprechen. Damit diese Versprechen auch eingehalten werden, müssen Brennstoffzellensysteme effizient, robust undvor allem sicher betrieben werden. Dies bringt Herausforderungen an die Betriebs- und Prozessführung mit sich und somit an die Regelung dieser Systeme. Teil 1 einer zweiteiligen Beitragsfolge stellt das Brennstoffzellensystem für die automobileAnwendung aus regelungstechnischer Sicht vor und verdeutlicht die Notwendigkeit und das Potential einer Regelung.
Microenvironment-related predictive markers of the therapeutic effectiveness of eribulin in patients with locally advanced or metastatic breast cancer: pilot study
Authors: Tashireva L.  A. , Popova N. O. , Alifanov V. V. , Goldberg V. E. , Kovalenko E. I. , Artamonova E. V. , Manikhas A. G. , Ponomarenko D. M. , Levchenko N. V. , Rossokha E. I. , Krasilnikova S. Yu. , Zafirova M. A. , Perelmuter V. M. 
Published: January 2022

Background. Triple negative breast cancer has no specific treatment sites for chemotherapy and is unfavorable in terms of prognosis. One of the drugs widely used in this cohort of patients is eribulin, which in addition to its antimitotic effect has an effect on the tumor microenvironment. The search for biological criteria that will allow predicting the effectiveness of the drug is assumed relevant since it will help to select patients who may receive the most benefit from certain therapy regimens.Objective: identification of immunological predictors of the therapeutic effectiveness of eribulin in patients with locally advanced or metastatic triple-negative breast cancer.Materials and methods. The study included 20 patients with locally advanced and metastatic triple negative breast cancer. 50 % had a short-term response (progression-free survival <3 months) to eribulin therapy, and 50 % had a long-term response (progression-free survival >6 months). Seven-color immunofluorescence was used to determine the subpopulation composition of tumor-infiltrating lymphocytes and their PD1 expression. Image acquisition and analysis were performed using the Vectra® 3.0 system and InForm® software (Akoya Biosciences, USA).Results. It has been shown that the ratio of the number of PD1-negative to PD1-positive CD20+ B-lymphocytes less than 5.5 associated with the long-term effectiveness of eribulin in patients with locally advanced or metastatic triple negative breast cancer.Conclusion. The results showed that the ratio of the number of PD1-negative to PD1-positive CD20+ B-lymphocytes can be considered as a possible marker to predict the effectiveness of eribulin in patients with breast cancer.
Principais Enterites Parasitárias em Cães: Revisão
Authors: Cristina Ferreira Pradoa Angélica , Santana Gonçalves Elaine , Pereira Michelli , Almeida Júnior Sávio Tadeu , Guedes Elizângela 
Published: January 2022

As enterites parasitárias são consideradas as principais causas de transtornos intestinais em cães domésticos (Canis familiaris), desempenhando um papel importante na saúde animal e saúde pública. Ancylostoma caninum, Toxocara canis. Giardia spp. Cryptosporidium spp. e Cystoisospora spp são os enteroparasitas descritos com maior frequência na rotina clínica. Considerando a importância da infecção por esses agentes em cães, o presente trabalho realizou uma revisão bibliográfica sobre os principais parasitas entéricos que acometem os cães, objetivando compreender seus aspectos biológicos, patogênicos, de diagnóstico, tratamento e sua profilaxia. O conhecimento do ciclo biológico e as formas de transmissão de cada parasito é imprescindível para compreender suas formas de disseminação, as técnicas diagnósticas apropriadas e a prevenção das enfermidades. O estreito convívio entre animais e o homem, principalmente no que se refere aos animais de companhia, vem propiciando o surgimento e ressurgimento de potenciais zoonoses. Dessa forma, o conceito de One Health deve estar, a cada dia, mais inserido na sociedade e principalmente entre os médicos veterinários.

Palavras-chave: Giardia. Caninos. Zoonose. Toxocara canis. Vermifugação.

Abstract
Parasitic enteritis is considered the main cause of intestinal disorders in domestic dogs (Canis familiaris), playing an important role in animal health and public health. Ancylostoma caninum, Toxocara canis. Giardia spp. Cryptosporidium spp. and Cystoisospora spp. are the most frequently described enteroparasites in clinical routine. Considering the importance of infection by these agents in dogs, the present work carried out a literature review on the main enteric parasites that affect dogs, aiming to understand their biological, pathogenic, diagnostic, treatment and prophylaxis aspects. Knowledge of the biological cycle and forms of transmission of each parasite is essential to understand its forms of dissemination, appropriate diagnostic techniques and disease prevention. The close relationship between animals and man, especially with regard to companion animals, has led to the emergence and resurgence of potential zoonosis. Thus, the concept of One Health must be, every day, more inserted in society and especially among veterinarians.

Keywords: Giardia. Canines. Zoonosis. Toxocara canis. Deworming.
THE FUNCTIONS OF HUMOROUS DISCOURSE IN MIND YOUR LANGUAGE
Authors: Romadlani Muhammad Masqotul Imam , Wijana I Dewa Putu 
Published: January 2022

The primary purpose of this study is to reveal the function of humorous discourse identified in the Mind Your Language situation comedy series. The researcher adopted a descriptive qualitative approach to complete this humor research. The data were obtained from the script of that sitcom. The function of humorous discourse found in that sitcom was then classified based on Hay's framework, which divides the function of humor into three main functions: the function of solidarity, the function of power, and the function of psychology. The findings demonstrate that teasing and satire humor in Mind Your Language sitcom are utilized to express solidarity. Meanwhile, humorous discourses that trigger conflict, harm, threaten others or show disagreement are created to express the function of power. Furthermore, humorous discourse to gain an advantage, protect oneself, entertain, or boast is used to express the function of psychology. The context of the conversation given is highly significant in identifying the function of humor. The same humorous discourse provided in different contexts potentially implicates different functions of humor which indicates that determining the function of humor is heavily grounded by the context.
Faculdade de educação da USP
Authors: Souza Maria Cecilia Cortez Christiano de 
Published: January 2022

Este artigo procura contemplar a criação da Faculdade de Educação da USP em 1970, tendo como fio narrativo material memorialístico produzido pela autora. A partir daí, objetiva contextualizar a emancipação da Faculdade de Educação da matriz original, a Faculdade de Filosofia, Ciências e Letras da USP. Tendo como pano de fundo o processo político vivido pela Universidade nos anos que antecederam e se seguiram à Reforma Universitária de 1968, discute as repercussões no plano interno da do Departamento de Educação e da Faculdade de Educação, relacionadas à devolução do Colégio de Aplicação à rede pública, bem como ao esvaziamento do Centro Regional de Pesquisas Educacionais de São Paulo a partir de 1970.
PENGARUH KARAKTERISTIK TIM DAN KEADILAN KERJA TERHADAP KOMITMEN ORGANISASI PADA GURU SMA SWASTA KOTA BEKASI
Authors: Faradiba Yasmin 
Published: January 2022

This research is aimed to investigate the effect of (1) team characteristis,, and (2) work justice toward (3) organizational commitment of teacher the private senior high school in Bekasi. In the data analysis, this research uses causal survey method by using Path Analysis Technique. This study uses the sample from 73 teachers in three private senior high school in Bekasi who are selected by using Slovinâ€™fomula. The result of the study reveals that: Frist, there is a positive effect between team characteristics and teacher organizational commitment to the school. Second, there is a positive effect also between work justice and teacher organizational commitment to the school. Third, there is a positive effect between team characteristics and teacher organizationaâ€™s commitment to the school.
Pelvic Ring Disruption During Childbirth
Authors: Hoehmann Christopher L. , Doss William , DeTore Saila 
Published: January 2022

Case:
We present the management of a peripartum pelvic ring disruption. Initial conservative treatment failed; ultimately, open reduction with internal fixation was required. Four years later, the patient gave birth to another child by elective cesarean delivery.

Conclusion:
Pelvic ring fracture is a rare occurrence during childbirth. The mechanism involves hormonally mediated ligamentous laxity of the pelvis combined with the forceful movement of the fetal head. This case highlights the continuum of care from injury to treatment, and follow-up, demonstrates proper management of pregnancy-related pelvic ring injury, and explores the role of previous pelvic ring injury in a pregnant patient.
Elbow Osteochondral Allograft Transplantation and Lateral Ulnar Collateral Ligament Repair with Internal Brace
Authors: Lee Steven J. , Bedford Benjamin B. , Kim Andrew H. , Rahman Omar F. , Zbeda Robert M. 
Published: January 2022

Case:
A 23-year-old woman with an Osborne-Cotterill lesion and posterolateral rotatory instability (PLRI) of the elbow was treated with osteochondral allograft transplantation (OCA) and lateral ulnar collateral ligament (LUCL) repair with internal brace. Two years after surgery, she reported resolution of pain and returned to all recreational activities. She reported no mechanical symptoms and no episodes of postoperative instability.

Conclusion:
PLRI can present with an Osborne-Cotterill lesion in addition to LUCL injury. The purpose of this case report was to describe the use of OCA to manage bony defects in the capitellum in addition to LUCL repair for patients with PLRI.
eDNA metabarcoding as a promising conservation tool to monitor fish diversity in Beijing water systems compared with ground cages
Authors: Mei Shen , Nengwen Xiao , Ziyi Zhao , Ningning Guo , Zunlan Luo , Guang Sun , Junsheng Li 
Published: January 2022

Abstract
Fish diversity, an important indicator of the health of aquatic ecosystems, is declining sharply due to water pollution, overfishing, climate change, and species invasion. Effective surveying and monitoring are prerequisites for protecting fish diversity. In this study, eDNA (environmental DNA)metabarcoding and ground cages were used to survey the fish diversity of the Chaobai and Beiyun Rivers in Beijing. Based on the two methods, the results showed that 40 species, belonging to 35 genera, 18 families, and six orders, were identified. The richness of fish identified by eDNA metabarcoding was higher than that captured by ground cages in both rivers. All fish captured by the ground cage method were recognized by eDNA metabarcoding, except Squalidus wolterstorffi and Saurogobio dabryi, which were captured only in ground cages. The correlation of relative abundance between the two methods was affected by the properties of the rivers, such as the flow rate. The relative abundance detected by eDNA metabarcoding was positively correlated with that of the ground cages in the Beiyun River, while no correlation was observed for the Chaobai River. Our results also suggest that the Chaobai River has higher fish diversity and a different population structure than the Beiyun River. The primary fish species of the Beiyun River are mainly pollution resistant. In addition to differences in natural factors, the development of urbanization is a major contributor to different community structures in the two Rivers. Our results show that eDNA metabarcoding as a new survey tool has great application prospects. It provides certain theoretical data and methodological references for the protection and management of river fish diversity.
Attitudes and Perceptions of University Students on Climate Change: Evidences from an International Study
Authors: Filho Walter Leal , Ayal Desalegn Yayeh , Wall Tony , Shiel Chris , Pac Arminda , Pace Paul , Mifsud Mark , Salvia Amanda Lange , Skouloudis Antonis , Moggi Sara , LeVasseur Todd , Antonio Garcia Vinuesa , Azeiteiro Ulisses M , Ioannis Nikolaou , Kovaleva Marina 
Published: January 2022

Abstract
Universities have an unrivalled potential to educate students on climate change issues and to actively engage them in climate affairs, both as citizens and influencers of future professions. Despite this potential and the many advantages of student engagement in climate change, less emphasis has been given to understanding students´ perceptions and attitudes towards climate change, in a way that may guide changes in the curriculum and teaching practices. Based on the need to address the existing literature gap, this paper assesses university students’ perceptions and attitudes towards climate change at the international level. This study comprises a survey of a sample of universities across the world and uses descriptive statistics to identify the most important trends across geographical locations of the universities. The study provides recommended actions that universities may enact in order to improve educational provisions in matters related to climate change and, by doing so, better prepare future professionals to cope with the challenges of a changing climate.
Translation, Cross-Cultural Adaptation, and Evaluation of Psychometric Properties of Cystic Fibrosis Stigma Scale
Authors: Oliveira Victor Hugo Brito , Mendonça Karla Morganna Pereira Pinto , Alchieri João Carlos , Pakhale Smita , Balfour Louise , Silva Whitney Houston Barbosa dos Santos , Nogueira Ivan Daniel Bezerra , Nogueira Patrícia Angélica de Miranda Silva 
Published: January 2022

Abstract
Background: Stigma is present during the lifespan of individuals with cystic fibrosis (CF); consequently, instruments to assess this psychosocial aspect are necessary. Few instruments are validated and adapted to Brazilian Portuguese. We aimed to translate, cross-culturally adapt, and evaluate psychometric properties of the CF stigma scale. Methods: We conducted an exploratory study of cross-cultural adaptation involving translation, back translation, revision by an expert committee, and a pre-test. Psychometric properties (content validity, test-retest reliability, and convergent validity) were analyzed based on the adapted version of the scale and responded by 52 Brazilian individuals with CF older than 18 years. Results: Translation and cross-cultural adaptation obtained kappa indexes higher than 0.61 on the expert committee phase and between 0.48 and 0.72 on pre-test. The Brazilian version of CF stigma scale showed excellent psychometric properties: i) internal consistency, α = 0.836; ii) mean correlation between items and test-retest: r = 0.886, p < 0.0001; and iii) convergent validity, CF stigma scale correlated positively with anxiety scale and negatively with general and specific scores of quality of life in CF. Conclusion: CF stigma scale was adequately translated and cross-culturally adapted for the Brazilian population. Psychometric properties of the Brazilian version favor its use in future studies regarding stigma conducted with Brazilian individuals with CF.
Axial Length Shortening After Orthokeratology and Its Relationship With Myopic Control
Authors: Wang Anken , Shen Li , Wang Jiaying , Zhang Zhehuan , Yang Weiming , Yang Chenhao 
Published: January 2022

Abstract
Purpose: To determine the pattern of axial variation in subjects with initial shortened axial length during the entire period of orthokeratology and to discuss the possibility of shortened AL after one month of orthokeratology becoming a predictor of myopia control.Method: This study retrospectively included 106 children with myopia aged 8 to 14 wearing OK lenses. eyes with shortened axial length (AL) at the first-month visit were enrolled in the axial length shortening (ALS) group, and 52 eyes without shortened AL were enrolled in the no axial length shortening (NALS) group. Axial length and refractive error at baseline and within the entire period of orthokeratology (20 months), including fitting, washout period and re-wear, were measured.Results: In the ALS group, AL became longer after shortening and slowly exceeded baseline; afterward, AL experienced a rebound during the washout period and shortened again if OK lenses were re-worn. After washout period, significant difference in AL (ALS:0.28±0.19 mm, NALS: 0.52±0.17 mm) and spherical equivalent(ALS:-0.43±0.44D, NALS:-0.91±0.40D) between the two groups were found(P＜0.05). The changes in AL and SE were both significantly correlated with the changes in AL at the first-month visit (P＜0.05).Conclusion: After AL is shortened in the initial stage of orthokeratology, it will experience a rapid rebound during the washout period, and the shortening can reappear when re-wearing OK lenses. Hence, only including the washout period can we make an objective evaluation of orthokeratology. In addition, the existence and degree of axial shortening can be used as a predictor of long-term myopia development.
ZO-1 regulates stress granule formation in endothelial cells by interacting with YB-1
Authors: Bakkouri Yassine El , Chidiac Rony , Corriveau Jeanne , Gaonac’h-Lovejoy Vanda , Chin Ashley , Lécuyer Éric , Angers Stephane , Topisirovic Ivan , Hulea Laura , Delisle Chantal , Gratton Jean-Philippe 
Published: January 2022

Abstract

Zonal occludens-1 (ZO-1) is involved in the regulation of cell-cell junctions between endothelial cells (ECs). Here, we define the ZO-1 protein interactome and reveal novel ZO-1 interactions with RNA binding proteins (RBP) that are part of stress granules (SGs). Exposure of ECs to stresses decreased ZO-1 protein levels which was accompanied by increased SG formation and protection of ECs from cellular insults. We uncovered a previously undocumented association between ZO-1 and Y-box Binding Protein 1 (YB-1). Arsenite treatment of ECs decreased the interaction between ZO-1 and YB-1. In turn, downregulation of ZO-1 increased the association of YB-1 and G3BP1, thus driving SG assembly. Importantly, YB-1 is essential for the protective effects induced by downregulation of ZO-1 and SG formation. Finally, in the developing retinal vascular plexus of newborn mice, ECs at the extremities of growing vessels express less ZO-1 and display more YB-1 positive SGs than ECs located in the median portion of the retinal vasculature. Together, our findings demonstrate an unsuspected role for ZO-1 in SG formation, through its interaction with YB-1, and in the response of ECs to stresses during angiogenesis.
Aerobic Vaginitis in the Third Trimester and Its Impact on Pregnancy Outcomes
Authors: Nguyen Anh Thi Chau , Nguyen Na Thi Le , Hoang Thu Thi Anh , Nguyen Tuyen Thi , Tran Trang Thi Quynh , Tran Dan Nu Tam , Tran Linh Manh , Nguyen Duc Huu Chau , Nguyen Anh Thi Kim , Le Tam Minh , Ho Binh Duy , Rööp Tiiu , Kõljalg Siiri , Štšepetova Jelena , Le An Van , Salumets Andres , Mändar Reet 
Published: January 2022

Abstract
Background

Aerobic vaginitis (AV) is a vaginal inflammation characterized by disruption of the lactobacillus microbiota and increased counts of different aerobic bacteria. AV may result in severe complications, especially during pregnancy, including preterm delivery, neonatal and maternal infections. This study aimed to determine the prevalence of AV in the third trimester of pregnancy, and the relationship between AV and pregnancy outcomes.
Methods

A cross-sectional descriptive study included 323 pregnant women attending for routine antenatal care in the Hue University Hospital. Vaginal samples collected at the third trimester of pregnancy were evaluated for AV according to the scoring system of Donders and cultured for identification of predominant bacteria. Pregnancy was followed to its end, and pregnancy outcomes were recorded for both mothers and infants.
Results

The proportion of pregnant women diagnosed with AV in the third trimester was found to be 15.5%, with the vast majority of the cases (84%) displaying the light AV and 16% the moderate AV. The vaginal cultures in the women with AV revealed most frequently Streptococcus agalactiae (6%), followed by Enterococcus spp (4%), Staphylococcus aureus (4%), and Acinetobacter baumannii (2%). In addition, AV during the last trimester of pregnancy was associated with an increased risk of puerperal sepsis (OR 8.65, 95% CI: 1.41 - 53.16, p = 0.020) and there was a slightly increased risk for neonatal infections, which was statistically insignificant.
Conclusions

The proportion of AV is relatively high in Vietnamese pregnant women. Since it is associated with an increased risk of puerperal sepsis, it needs to be diagnosed and treated before delivery.