bluuebunny/crossref_metadata_2025_split huggingface dataset:
An Agile Model Of A Hybrid Approach To Enhance The Sustainability Of Production Management System In Industry 4.0
Authors: Tripathi Varun , Chattopadhyaya Somnath , Mukhopadhyay A.K. , Sharma Shubham , Singh Jujhar , Li Changhe , Bona Gianpaolo Di 
Published: March 2022

Abstract
In industry 4.0, industry individuals are emphasizing enhancing the adaptability of the production management system by a suitable approach. To accomplish it, the management individuals use various process optimization approaches includes lean manufacturing, smart manufacturing, computational intelligence, and hybrid approaches. Process optimization approaches are used to enhance production within limited constraints. The present research aims to develop an agile model using a hybrid approach for productivity enhancement in industry 4.0, this hybrid approach is the integration of lean, smart, and computational intelligence. The developed model has been validated through a case study of real production conditions in industry 4.0. The results obtained in the case study shown that the developed model can enhance production within limited constraints in industry 4.0. The authors believe that the developed model would be able to obtain productivity enhancement and providing guidelines to industry personals for improvement in the sustainability of the production management system in industry 4.0.
Superimposed Multilayer Randomly Distributed Graphene Quantum Dots and Broadband Terahertz Perfect Absorber
Authors: Deljou Seyyed Hadi , Rostami Ali , Yadipour Reza 
Published: March 2022

Abstract
For investigating broadband perfect absorption in the Terahertz region, a multilayer structure using superimposed Graphene quantum dots with Gaussian distribution radius is proposed. At first, a three-layer metamaterial structure, which is composed of graphene quantum dots at the top layer, dielectric material at the middle layer, and finally gold layer at the bottom is considered and investigated. The radius Gaussian distribution for three radii 400, 450, and 500 nm is considered. Results for the proposed structure including 3, 5, and 7 layers are extracted and compared. Simulation results for the 7-layer case show a broadband absorption range of (4.2THz to 8.1THz), and (4.3THz to 8.71THz) absorption value above 70%. The dielectric material is Si3N4 in the proposed structure.
Epidemiology and prognostic nomogram for esophageal cancer with liver metastasis based on the Surveillance, Epidemiology, and End Results database
Authors: Xiong Huacai , Hu Danfei , Li Mingyao , Chen Tian , Jiang Wei , Xiang Zhenfei 
Published: March 2022

Abstract
Background
The prognosis of esophageal cancer with liver metastasis (ECLM) is poor. This study evaluated the incidence and prognostic factors of ECLM at initial diagnosis and developed a visual nomogram to predict outcomes.
Methods
1892 eligible ECLM patients diagnosed between 2010 and 2016 were extracted from the Surveillance, Epidemiology, and End Results database (SEER). The incidence, patient overall survival (OS), and prognosis of liver metastasis were evaluated according to patient information, tumor characteristics, and therapy. Cox regression analyses were applied to evaluate prognostic factors. Based on the significant demographic and clinicopathologic factors, a novel visual nomogram was established to predict 6-month and 1-year survival for ECLM patients.
Results
The incidence of ECLM increased with age, but survival rates showed the opposite trend. From 2010 to 2016, as age increased, the incidence also increased annually, peaking at age 70 to 79 years and then decreasing. The 1-, 3-, 6-, 9- and 12-month relative cancer survival rates for ECLM patients were 84.6%, 61.3%, 44.0%, 31.4%, and 21.8%, respectively. Multivariate cox regression analysis revealed that age, gender, grade, histological type, bone metastasis, lung metastasis, brain metastasis, chemotherapy and local treatment were independent prognostic factors related to OS. Moreover, our nomogram predicted the 6-month and 1-year survival times of the population, with a C-index of 0.735 (95% CI: 0.723–0.748). The nomogram demonstrated good clinical applicability.
Conclusions
The incidence of ECLM increased with age, but survival rates showed the opposite trend. Age, gender, tumor characteristics, and therapy should be considered when predicting the prognosis of ECLM patients. The nomogram may improve clinicians’ abilities to predict individual survival and recommend treatments for ECLM patients.
Experiences and satisfaction of patients in communicating with care providers: The case of Afaan Oromoo speaker patients at Saint Paul's Hospital Millennium Medical College, Addis Ababa, Ethiopia, 2021
Authors: Gadisa Lalisa M , Belete Yibeltal Siraneh , Demshasha Sifessa D , Nuramo Biniam Gintamo 
Published: March 2022

Abstract
Background
Miscommunication between patient and care provider in health service setting puts great pressure on patient satisfaction even up to life threatening especially for official language minority group. However Oromoo people is largest ethnic group in Ethiopia, there is no study conducted pertaining experiences and satisfaction of Afaan Oromoo Speaking Patients in Saint Pauls’ Hospital Millennium Medical College (SPHMMC).
Objective
Objective of this study was to explore experiences and satisfaction of Afaan Oromo speaking patients in communicating with care providers in the SPHMMC, Addis Ababa, Ethiopia, 2021.
Methods and Materials:
A phenomenological qualitative study design was employed. To select Afaan Oromoo speaking patients from each departments of SPHMMC, purposive non-probability sampling technique was used. Data collection instrument for this study was in-depth interview, observation and Focus Group Discussion. Before data analysis and interpretation, collected data was transcribed, translated, coded and managed to simplify for analysis by computer assisted software open-code version-4. The raw data was handled carefully from loosing of valuable data using computer password. After core meaning of collected data was identified and explained using method of thematic content analysis, final report/finding was written.
Result
Experiences AOSPs in communicating with care providers showed indicated, most of health care providers were not used translator and to handle the problem they use non-verbal communication. Misunderstanding of patient condition, difficulty to record accurate patient assessment, misunderstanding of Afaan Oromoo word which caused for diagnosis of seemed diagnosis were observed from patient phenomena. Six themes which were taken from patient experience indicated dissatisfaction to health service and are: Service delay, mistrust b/n care providers and patients, loss of confidence and loss of self-esteem among patients, exposing to unnecessary expenditure, and communication gap in service provision.
Conclusion & recommendation:
Experiences of AOSPs in communicating with health care providers clearly indicated their dissatisfaction to health service. Thus, SPHMMC, FMoH and RHBO have been recommended to establish LAS, professional interpreters, and to function corporately with concerned stakeholders.
Fungal Community Compositional Diversity and Fragrant Components in Medium- and High-Temperature Taorong-Type Daqu
Authors: liu yanbo , Li Xin , Li Haideng , Zhang Huimin , Shen Xiangkun , Zhang Lixin , Han Suna , Pan Chunmei 
Published: March 2022

Abstract
The microbial communities and fragrant components of Taorong-typed were analyzed using high-throughput sequencing (HTS) and headspace-solid phase microextraction-gas chromatography-mass spectrometry (HS-SPME-GC-MS). At the phylum and genus levels with abundance ≥0.01% as the threshold, 3 phyla including Mucoromycota, Ascomycota, Basidiomycota were found in both medium-and high-temperature Daqu, but the abundances differed. At the genus level, 15 and 13 genera were recognized. Rhizopus (72.40%) and Thermomyces (53.32%) accounted for the largest proportions in medium- and high-temperature Daqu respectively. The medium-temperature Daqu and high-temperature Daqu were found with 40 and 29 fragrant components respectively, and contained the highest proportions of pyrazines (53.12%) and acids (32.68%) respectively. Correlation analyses between microbes and fragrant components showed Aspergillus , Hyphopichia , Trichosporon and Alternaria were all highly and positively correlated with pyrazines, but the dominant fungal communities were highly correlated only with a few single acid compounds, but not with acid compounds on the whole.
Development Of COVID-19 Severity Assessment Score In Adults Presenting With COVID-19 To The Emergency Department
Authors: Subhani Faysal , Chhotani Abdul Ahad , Waheed Shahan , Zahid Rana Osama , Azizi Kiran , Buksh Ahmed Raheem 
Published: March 2022

Abstract
Background: Critically-ill Covid-19 patients require extensive resources which can overburden a healthcare system already under strain due to a pandemic. A good disease severity prediction score can help allocate resources to where they are needed most. Objectives: We developed a Covid-19 Severity Assessment Score (CoSAS) to predict those patients likely to suffer from mortalities within 28 days of hospital admission. We also compared this score to Quick Sequential Organ Failure Assessment (qSOFA) in adults.Methods: CoSAS includes the following 10 components: Age, gender, Clinical Frailty Score, number of comorbidities, Ferritin level, D-dimer level, neutrophil/lymphocyte ratio, C-reactive Protein levels, systolic blood pressure and oxygen saturation. Our study was a single center study with data collected via chart review and phone calls. 309 patients were included in the study.Results: CoSAS proved to be a good score to predict Covid-19 mortality with an Area under the Curve (AUC) of 0.78. It also proved better than qSOFA (AUC of 0.70). More studies are needed to externally validate CoSAS.Conclusion: CoSAS is an accurate score to predict Covid-19 mortality in the Pakistani population.
Morphometric parameterization of flash flood risk assessment
Authors: Zelenakova Martina , Harbulakova Vlasta Ondrejka , Junakova Natalia , Hlinkova Maria , Fijko Rastislav , Abd-Elhamid Hany F. 
Published: March 2022

Abstract
Individual morphometric characteristics of river basins have a significant impact on its activity; affect the flow rate of water, water accumulation in the river basin, water runoff time and other attributes that affect their intensity during flash floods as well as hydrological droughts. The aim of the paper is to express the risk and impact of flash floods in the Topla River basin (Slovakia) and its sub-basins with regard to the morphometric characteristics of the area. The studied locality, especially spring of the Topla river, belongs to the area with an existing, potentially significant flood risk threatening not only important localities but also the population. The objective is to support the territories with flood mitigation measures by assessing the basin morphometric factors and to classify such areas into high, medium and low risk categories of flash floods. The model situation is developed in the ArcGIS program where the selected important morphological characteristics are assigned to all sub-basins for the Topla river together with its assessment and for each characteristic, the level of risk affecting the flash flood is determined. An important part of this study is developing a river basin susceptibility scales to flood activity in the terms of morphometric characteristics obtained from available literature, empirical relationships and human experiences The result of the sensitivity risk map of the upper part of the Topla river basin is to show, where adverse impacts on people and the surrounding environment are expected after flash floods hitting (or in the event of hydrological droughts).
Association of Periprocedural Phentolamine Infusion with Favorable Outcome in Patients with Chronic Kidney Disease and Chronic Coronary Syndrome undergoing coronary catheterization: A Prospective Randomized Controlled Study
Authors: Hamila Mohamed Abo , Ghawaby Helmy El , Zaki Mohamed , Soliman Mohamed , Gabr Khaled 
Published: March 2022

Abstract
BackgroundChronic kidney disease (CKD) is a major risk factor for contrast induced nephropathy acute kidney injury (CIN-AKI) in chronic coronary syndrome (CCS) patients undergoing coronary catheterization. We aimed to evaluate the efficacy of phentolamine in prevention of CIN-AKI in CKD and CCS patients undergoing percutaneous coronary catheterization for diagnostic angiography ± stenting.MethodsParticipants with CKD and CCS planned for percutaneous coronary catheterization were included, while participants with normal kidney functions were excluded. A consecutive sample of 107 participants (mean age 58.62 ± 8.96 years, 64.5% males) was selected, underwent diagnostic coronary angiography or percutaneous coronary intervention, and received either conventional CIN-AKI prevention strategy (group 1) or periprocedural phentolamine and conventional CIN-AKI prevention strategy (group 2).ResultsThe percentages of study participants who had CIN-AKI were 82.9% for group 1 and 17.1% for group 2, respectively. There were a statistically significant association between periprocedural phentolamine and prevention of CIN-AKI (OR = 0.041, 95% CI 0.0149–0.1128, P < 0.0001) and statistically significant differences between group 1 versus group 2 regarding the urine output (ml/kg) and the urine output (ml/hour) within 72 hours post procedure, the peak change in serum creatinine within 72 hours post procedure, the percentage of change relative to the baseline serum creatinine at 72 hours post procedure, and the incidence rate of major adverse cardiac and cerebrovascular events within 90 days post procedure (t(105)= -0.69, p < 0.001, t(105)= -52.46, p < 0.001, t(102) = 0.2, p 0.018, t(102) = 23.54, p < 0.001, and t(102) = 1.168, P < 0.001, respectively).ConclusionsThe incidence of CIN-AKI and the peak change in serum creatinine within 72 hours post procedure was lower in CKD patients who underwent coronary catherization and received phentolamine infusion versus intravenous saline. The significant association of phentolamine infusion with prevention of CIN-AKI highlights the potential role of phentolamine for protection of the kidney in CKD patients planned for coronary catherization.Trial Registration Number:I-111015 Date of Trial Registration: 01/06/2016
Morphology of subsurface cracks induced by Vickers indentation observed by synchrotron X-ray multiscale tomography: a case study of CaO−Al 2 O 3 −SiO 2 glass- ceramic
Authors: Okuma Gaku , Maeda Kei , Yoshida Satoshi , Takeuchi Akihisa , Wakai Fumihiro 
Published: March 2022

Abstract
The characterization of subsurface cracks induced by indentation is a challenge for understanding contact damage, impact, wear, erosion, and abrasion of brittle materials, because the crack pattern observable on the surface is only a part of the total crack system. Here we applied synchrotron X-ray multiscale tomography to observe the morphology of subsurface cracks produced by Vickers indentation in a novel CaO-Al2O3-SiO2 glass-ceramic with plate-like crystals forming a house-of-cards microstructure. It revealed a diverse type of crack systems around the semispherical microcrack zone beneath the indent, including a new mode II inclined lateral crack driven by the maximum shear stress. Tomography images provided knowledge on how the heterogeneous microstructure affected the toughening processes such as crack deflection, crack bridging, and microcracking.
A novel microbial-plant coupled reactor for remediating acid mine drainage and optimization of carbon sources
Authors: Lin Hai , Tang Yalu , Dong Yingbo 
Published: March 2022

Abstract
Acid mine drainage (AMD) is recognized as one of the most serious contamination sources in the nonferrous metal mining industry. In this study, aerobic strains VCZ02 and VCZ09, which were identified as Leclercia adecarboxylata and Klebsiella aerogenes, were screened from 11 strains of copper-zinc-resistant bacteria in the soil of the Dexing copper mine with Cu2+/Zn2+ removal rates of 46.32% / 41.03% and 57.96% / 67.05%, respectively. The composition of extracellular polymers plays an important role in the removal of heavy metals by these two strains. A mixed community consisting of VCZ02 and VCZ09 was coupled with Sagittaria sagittifolia L. to construct a microbial-plant coupled reactor to remediate AMD. Under the optimal condition of sodium acetate as carbon source, the pH of AMD increased from less than 5 to above 6.5, showing Cu2+/Zn2+ removal rates of 70-80% and above 30%, respectively. SEM–EDS results showed that VZC02 and VZC09 in the coupled reactor also helped with resisting the toxicity of heavy metals to plants by forming biofilms on the root surface and increasing the content of heavy metals on the surface of roots, thus improving the treatment effect of plants. This study provides a theoretical basis for the bioremediation of AMD and its application.
dsSynthetic: Synthetic data generation for the DataSHIELD federated analysis system
Authors: banerjee soumya , Bishop Tom RP 
Published: March 2022

Abstract
Objective Platforms such as DataSHIELD allow users to analyse sensitive data remotely, without having full access to the detailed data items (federated analysis). While this feature helps to overcome difficulties with data sharing, it can make it challenging to write code without full visibility of the data. One solution is to generate realistic, non-disclosive synthetic data that can be transferred to the analyst so they can perfect their code without the access limitation. When this process is complete, they can run the code on the real data. Results We have created a package in DataSHIELD ( dsSynthetic ) which allows generation of realistic synthetic data, building on existing packages. In our paper and accompanying tutorial we demonstrate how the use of synthetic data generated with our package can help DataSHIELD users with tasks such as writing analysis scripts and harmonising data to common scales and measures.
Evaluation Of Porcine Somatic And Testicular Germ Cells During Differentiation And Proliferation
Authors: Tabar Amirreza Niazi , Azizi Hossein , Roshan Mehdi Mehdinezhad , Alipour Hiva 
Published: March 2022

Abstract
Background: Spermatogenesis is the complex process of sperm production to transmit paternal genetic information to the subsequent generation. This process is determined by the collaboration of several germ and somatic cells, most importantly spermatogonia stem cells and Sertoli cells. To characterize germ and somatic cells in the tubule seminiferous contort in porcine and consequently has an impact on the analysis of porcine fertility.Materials and methods: Germ cells were extracted from porcine testis by enzymatic digestion before being expanded on Sandos inbred mice (SIM) embryo-derived thioguanine and ouabain-resistant fibroblasts (STO) feeder layer supplemented with FGF, EGF, and GDNF. Immunohistochemistry (IHC) and immunocytochemistry (ICC) analysis for Sox9, Vimentin, and PLZF markers were performed to examine the generated colonies of porcine testicular cells. Electron microscopy was also utilized to analyze the morphological features of the extracted porcine germ cells.Results: IHC analysis revealed that Sox9 and Vimentin were expressed in the basal compartment of the seminiferous tubules. Moreover, ICC results showed that the cells have low expression of PLZF while expressing vimentin. Heterogeneity of the in vitro cultured cells was detected via morphological analysis by the electron microscope. Conclusion: In this experimental study, we tried to reveal the exclusive information which obviously could be helpful for future success in achievement to proper therapies against infertility and sterility as an important global issue.
Genetic and Immunological Characterization of Commercial Infectious Bronchitis Virus (IBV) Vaccines Used in Korea
Authors: Park Jeongho , Jung Ji Seung , Lee Rangyeon , Yoon Sung-il , Lee Geun-Shik , Sung Hann Woo , Kwon Hyuk Moo 
Published: March 2022

Abstract
Infectious bronchitis virus (IBV) is the avian coronavirus that was first isolated eight decades ago and it has remained as a major contagious pathogen in the poultry industry. Although vaccination is considered the most effective preventive strategy, continuously emerging variants prohibit vaccine efficacy and cross protection. In the last two decades, because nephropathogenic strains have been prevalent, the basic structure of numerous live attenuated vaccines was based on them. For a better understanding of their antigenic and immunogenic properties, this study obtained three commercial IBV vaccines commercially available in Korea and analyzed their genetic and immunogenic features. S1 gene sequence comparison with other field strains clustered those vaccine strains into the GI-19 or GI-15 lineage. The genetic variance of vaccine strains from their parental viruses was mostly detected in HVRI. Although each vaccine strain targets both respiratory and nephrotropic IBVs, their amino acid residues were not comparable at multiple locations. Conversely, antigenic stimulation with commercial vaccines and regional IBV variants was not sufficient to modify major immune cell phenotypes. Our study suggests that vaccine selection should be carefully considered according to their structural background because genetic variance can still exist even during the manufacturing process. Further investigation of the precise immune response by each vaccine strain can improve quarantine strategies.
Rapid and Cost-Efficient Screening of Bacterial Antibiotic Susceptibility in Enterobacteriaceae – An Assay Measured by Absorbance
Authors: Axelsson Carolina , Nilson Bo , Rehnstam-Holm Ann-Sofi 
Published: March 2022

Abstract
Objectives: Due to the rise in antimicrobial resistance worldwide, it is becoming increasingly important to rapidly receive information on the antimicrobial susceptibility of isolated bacteria. Traditional phenotypic methods are slow but remain useful and have advantages such as low cost, as well as being easy to perform and having established analysis criteria. The objective of this study was to develop and evaluate a rapid assay that can detect antibiotic resistant bacteria phenotypically in less than 2 hours.Methods: The microplate assay is based on absorbance measurements of bacterial strains grown in liquid media with and without antibiotics (cefotaxime, meropenem and ciprofloxacin). The absorbance was measured at the beginning of the assay, and after 90 minutes of incubation. If a bacterial isolate in absence of antibiotic had more than a 50% growth increase after 90 minutes, then the susceptibility/resistance was calculated by comparing the absorbance value of the culture in the presence of antibiotic at 90 minutes with the initial absorbance value.Results: Here we show that it is possible to phenotypically screen antibiotic susceptibility of both clinical and environmental Enterobacteriaceae isolates in 90 minutes for three different antibiotics. The test showed an accuracy of 98,5%, a sensitivity of 97,4%, and a specificity of 99,3%. False susceptibility rates were 0,4% and false resistance rates were 1,2%. Conclusion: This rapid and simple absorbance test has proven suitable for screening of antibiotic susceptibility for a large number of Enterobacteriaceae strains with high accuracy and sensitivity. The method can be performed without specialized and costly materials and/or equipment, which makes it highly suitable for laboratories with limited resources and might be especially important in laboratories situated in low income countries.