bluuebunny/crossref_metadata_2025_split huggingface dataset:
Spouses as trained ICU doulas have significant effects on the psychological outcomes of intensive care survivors: A retrospective secondary analysis
Authors: Samim Abbas , Rahimi-Bashar Farshid , Gohari-Moghadam Keivan , Izadi Morteza , Karimi Leila , Jarineshin Hashem , Ghamari Ali Akbar , Amini Hossein , Barasteh Salman , Jafari-Iraqi Iman , Vahedian-Azimi Amir 
Published: April 2022

Abstract
The purpose of this study was to investigate the effect of psychological support provided by the patient's spouse as trained ICU doulas on mental disorders after 12 months of hospital discharge. This retrospective secondary analysis was conducted on married patients (patient- and patient's spouse as a unit) with no history of mental disorders. In this study, three groups of patients were compared with each other; ICU survivors with trained spouse as ICU-doulas (n = 359, 29%), ICU survivors without trained spouse (n = 461, 37.3%) and discharged patients from general wards without trained spouse (n = 416, 33.7%). In multivariate binary logistic regression, the odds ratio (OR) of mental disorders based on WHO-5 index (OR: 0.344, 95% CI: 0.265–0.446, P < 0.001), HADS-depression score (OR: 0.762, 95% CI: 0.593–0.979, P = 0.033), HADS-anxiety score (OR: 0.372, 95% CI: 0.287–0.481, P < 0.001) and IES-R score (OR: OR: 0.367, 95%CI: 0.184–0.875, P < 0.001), were significantly decreased in the ICU survivor with trained spouse as ICU-doulas compared with the ICU survivors without doulas. However, there was no statistically significant difference was found between ICU survivors without doulas and no ICU patients without doulas. Our data suggest that the patient's spouse as trained ICU doulas could feasibly and successfully provide psychological support in the ICU setting. Since psychologist support by patient's spouse is not associated with any adverse effects, implementing this service should be considered.
An assessment of strategies for sustainability priority challenges in Jordan using a Water-Energy-Food Nexus approach
Authors: Ramirez Camilo , Almulla Youssef , Joyce Brian , Huber-Lee Annette , Nerini Francesco Fuso 
Published: April 2022

Abstract
This study aimed at supporting robust decision-making for planning and management of water-energy-food Nexus systems in the country of Jordan. Nexus priority challenges in Jordan were identified as 1) water scarcity, 2) agricultural productivity & water quality, and 3) shift to energy independence. We created a water-energy-food Nexus model that integrates three modelling frameworks: 1) the Water Evaluation and Planning system WEAP model to estimate water demands, supplies and allocation; 2) the MABIA model to estimate crop production, and, 3) a GIS-based energy modelling tool to estimate energy requirements of the water system. Through a set of scenario runs, results show how desalination is needed to address water scarcity, but it has to be coupled with low-carbon electricity generation in order to not exacerbate climate change. Improving water productivity in agriculture improves most of the studied dimensions across the water-energy-food security nexus; however, it does little for water scarcity at the municipal level. Reducing non-revenue water can have positive effects on municipal unmet demand and reduction of energy for pumping, but it does not improve agricultural water productivity and may have negative feedback effects on the Jordan Valleys aquifer levels. Energy efficiency can support energy intensive projects as desalination by substantially reducing the load on the energy system, preventing increased emissions and achieving a more resilient water system. Finally, when all interventions are considered together all of the major drawbacks are reduced and the benefits augmented, producing a more holistic solution to the WEF Nexus challenges in Jordan.
Prognostics of systemic malignancy ICD-O topography and morphology types on brain metastases: an NCDB time-to-event cohort
Authors: Alexopoulos Georgios , Zhang Justin , Karampelas Ioannis , Patel Mayur , Mercier Philippe 
Published: April 2022

Abstract
Background: The primary site and histology of systemic malignancy are known predictors of progression to brain metastases(BM). We investigated the combinational interactions of ICD-O primary topography and morphology types on the survival of BM after adjusting for relevant clinical and demographic prognostic factors. Methods: The cohort included all adult patients with BM at diagnosis of an invasive malignancy in the National Cancer Database(2010-2018). The sample consisted of 180,150 entries out of 14,279,749 cancer patients screened. A survival analysis of the topography- and histology- specific time to death was performed. Multivariate Cox regression revealed violations of the proportional hazard assumption for multiple covariates. Parametric models using a log-logistic distribution best described the population survival pattern. Results: The primary topography “prostate” and morphology “choriocarcinoma” provided the strongest survival benefit among ICD-O types, while BM from prostate demonstrated a 14-month median overall increase in survival probability. Favorable prognostics were BM from breast, bone/joints, and testis; also, the morphologies of carcinoid tumor, mature B-cell lymphoma, and papillary adenocarcinoma. Poor prognostics were BM from gastrointestinal(liver, biliary tree, pancreas, gallbladder) and gynecologic malignancies. All morphologies of spindle cell carcinoma, hemangiosarcoma, undifferentiated carcinoma, Ewing sarcoma, pseudosarcomatous carcinoma, renal cell carcinoma/sarcomatoid, signet ring cell carcinoma, spindle cell sarcoma, and squamous cell carcinoma/spindle cell were associated with poor survival. Conclusions: This is the largest cohort providing an unbiased estimate of the adjusted ICD-O topography and morphology effect sizes. The results can be summarized as a booklet for prognostic classification of disease in patients with BM secondary to systemic malignancy.
The relationship between kinesiophobia, physical performance and balance in lower extremity lymphedema patients
Authors: PEHLİVAN Büşra , ERDOGANOLU Yıldız , OF Nur Selin , TÜZÜN Şansın 
Published: April 2022

Purpose: Lymphedema is an important situation that causes physical and psychological life-threatening problems. This study researches kinesiophobia in lower extremity patients and scrutinizes the relationship between kinesiophobia, physical performance and balance.
Methods: This cross-sectional controlled study included 40 individuals diagnosed with lower extremity lymphedema with a mean age of 42.58±10.30 years and 31 healthy individuals with a mean age of 40.65 ± 9.53 years. The evaluation of patients with unilateral lymphedema without cognitive and visual problems and those without orthopedic and neurological disorders that would prevent walking and those without heart disease and hypertension was carried out between November 2018 and March 2019. Static balance was evaluated with standing on One leg Balance Test, fear of movement was evaluated with Tampa Scale Kinesiophobia and functional levels were evaluated with Timed Up and Go test.
Results: Static balance and physical performance of lower extremity lymphedema patients were found to be statistically different than healthy individuals (p
Peran Perempuan Pesisir Terhadap Ketahanan Keluarga Pasca Bencana Alam Gempa Bumi Di Desa Maliaya, Kabupaten Majene Tahun 2021
Authors: Susanti Eni 
Published: April 2022

Penelitian ini bertujuan untuk mengetahui peran perempuan pesisir pasca bencana alam gempa bumi di Desa Maliaya, Kabupaten Majene , serta upaya mereka mengatasi masalah ekonomi dan sosial dalam keluarga. Kami juga mengamati upaya perempuan sebagai cara untuk menghilangkan trauma pada anggota keluarga mereka. Penelitian ini menggunakan pendekatan kualitatif dengan mewawancarai delapan ibu rumah tangga yang berpengalaman langsung dalam menghadapi bencana alam. Penelitian dilakukan di desa maliaya, kecamata, Malunda. Kabupaten Majene, Provinsi Sulawesi Barat. Pengumpulan data dilakukan dengan observasi dan wawancara mendalam. Teori yang digunakan dalam penelitian ini adalah tentang perempuan pesisir, peran perempuan dalam keluarga maupun masyarakat, ketahanan keluarga serta gender. Hasil dari penelitian ini adalah bahwa Perempuan pesisir di Desa Maliaya memegang peranan penting dalam menjaga ketahanan keluarga pasca terjadinya gempa bumi yang melanda Kabupaten Majene. Secara ekonomi mereka sudah memenuhi indikator ketahanan keluarga, namun secara fisik, penulis masih banyak menemukan mereka yang belum memiliki rumah pribadi dan masih tinggal bersama orang tua. Keluarga di Desa Maliaya terutama perempuan dan anak- anak juga masih merasakan trauma pasca terjadinya gempa bumi yang melanda Kabupaten Majene. Perempuan pesisir di Desa Maliaya juga sudah menerapkan kesetaraan gender kepada keluarga dan juga anak-anaknya.
Efektivitas Pola Tanam Dan Sistem Distribusi Bunga Pacar Di Subak Desa Singapadu Kaler
Authors: Setena Made , Swabawa Agung Putu 
Published: April 2022

Penelitian ini dilakukan di subak yang ada di Desa Wisata Singapadu Kaler. Tujuan penelitian ini adalah untuk mengetahui efektivitas penerapan pola tanam dan sistem distribusi bunga pacar yang dilakukan oleh para petani bunga pacar, sehingga dapat membantu menerapkan pola tanam dan sistem distribusi yang efektif yang diterapkan dalam meningkatkan pendapatan petani yang menanam bunga pacar di Desa Singapadu Kaler. Pengumpulan data yang dilakukan dengan menggunakan metode observasi, wawancara, dokumentasi, dan studi pustaka. Alat analisis yang digunakan untuk Teknik analisisis kuantitatif yaitu teknik untuk menganalisis data yang berupa angka dengan menggunakan alat analisis, yang berupa: Analisis BCR ( Benefit Cost Ratio ) dan Analisis Profit Margin, yaitu analisis untuk melihat efektivitas pola tanam yang dikaitkan dengan sistem distribusi yang digunakan. Sedangkan untuk mgalisis data kualitatif mengunakan teknik analisis deskriptif, yaitu menguraikan dan membantu analisis kuantitatif mengambil kesimpulan. Berdasarkan hasil analisis menunjukkan ada para petani yang menerapkan pola tanam dengan sistem kontinyu dan ada yang menerapkan sistem intermitten (berselang). Pola tanam dengan sistem kontinyu lebih menguntungkan dari sistem intermtten. Untuk itu, sebaiknya para petani lebih efektif menerapkan pola tanam dengan sistem kontinyu dengan perbaikan pemeliharaan tentang pemupukan dan penyemprotan obat bunga yang lebih intensif. Sistem distribusi yang diterapkan oleh para petani pacar adalah sistem tidak langsung dengan menjual bunga pacarnya kepada agen, tetapi tidak langsung kepada konsumen. Sistem ini sudah efektif, namun kurang maksimal. Setelah dilakukan analisis perbandingan dengan sistem ditribusi langsung dengan tiga sasaran pasar yang berbeda, sistem yang diterapkan kurang efektif. Dari tiga alaternatif yang dianalisis, sistem distribusi langsung dengan sasaran pasar hotel paling efektif dibandingkan sasaran pasar Mambal dan pasar luar Mambal. Untuk memenuhi kebutuhan sasaran hotel, sangat perlu menjaga kualitas bunga pacar yang selalu dalam kondisi segar dan kontinyuitas ketersediaannya yang harus dijaga.
DNA Sequencing Analysis of Cystic Fibrosis Transmembrane Regulator Gene Identifies Cystic Fibrosis-Associated Variants in the Severe Asthma Research Program.
Authors: Izquierdo Manuel E. , Marion Chad R. , Moore Wendy , Raraigh Karen , L Jennifer Taylor-Cousar , Cutting Gary , Ampleford E. , Hawkins Gregory A. , Zein Joe , Castro Mario , Denlinger Loren C. , Erzurum Serpil , Fahy John , Israel Elliot , Jarjour Nizar , Mauger David , Levy Bruce D. , Wenzel Sally , Woodruff Prescott , Bleecker Eugene , Meyers Deborah A. , Ortega Victor E. 
Published: April 2022

Background: Heterozygote carriers of potentially pathogenic
variants in the cystic fibrosis transmembrane conductance regulator (
CFTR) gene have increased asthma risk. However, the frequency and
impact of CFTR variation among individuals with asthma is
unknown. Objective: To determine whether potentially
pathogenic CFTR variants associate with disease severity and
whether individuals with two potentially pathogenic variants exist in a
severe asthma-enriched cohort . Methods: We analyzed sequencing
data spanning a 190.5Kb region of CFTR in participants from the
Severe Asthma Research Program (SARP1-3). Potentially pathogenic, rare
CFTR variants (frequency<0.05) were classified as
CF-causing or of varying clinical consequences (VVCC) (CFTR2.org).
Regression-based models tested for association between
CFTR genotypes (0-2 potentially pathogenic variants) and severity
outcomes. Results: Of 1401 participants, 9.5% (134) had one
potentially pathogenic variant, occurring more frequently in
non-Hispanic white (NHW, 10.1% [84 of 831]) compared to African
American individuals (AA, 5.2% [22 of 426]). We found ≥2
potentially pathogenic CFTR variants in 1.4% (19); 0.5% (4) of
NHW and 2.8% (12) of AA. Potentially pathogenic CFTR variant
genotypes (≥1 or ≥2 variants) were not cumulatively associated with lung
function or exacerbations. In NHW, we found three F508del compound
heterozygotes with F508del and a VVCC (two
5T;TG12[c.1210-11T>G] and one Arg1070Trp) and a
homozygote for the VVCC, 5T;TG12. Conclusions: We found
potentially pathogenic CFTR variants within a severe
asthma-enriched cohort , including three compound heterozygote genotypes
variably associated with CF in NHW individuals. These findings provide
the rationale for CFTR sequencing and phenotyping of CF-related
traits in individuals with severe asthma.
ARBUSCULAR MYCORRHIZAE FUNGI AND SUSTAINABILITY OF ARTISANAL GOLD MINING WASTE DISPOSAL SITE REVEGETATION
Authors: Adyari Bob , Supriatun Titin , Rossiana Nia , Kramadibrata Kartini 
Published: April 2022

Mining areas is associated with barren, highly altered soil structure, poor soil nutrients and high heavy metals concentration. Those condition, in some way may influence plant and its microbial symbion adaptation in order to establish vegetation. Arbuscular Mycorrhizae Fungi (AMF) form symbiosis to plant and provide both side beneficial. Because of its importance, AM F are addressed as important aspect in revegetation. In this paper we describe about AMF present in Artisanal Gold Mining (AGM) waste disposal site and furthermore we review about AMF adaptation in facing climate change. AMF spore and colonization were observed under microscope. Generally, 5 AMF species from genus Glomus and Acaulospora had been found. AMF Spore density varied from 8-162 spore/ 150 gram soil. Root colonizations were found in 8 plant species with percentage range from very low to high category. The highest concentration of mercury (135,4 ppm), Pb (51,4 ppm), and Cyanide (5,6 ppm) is followed by supreme AM diversity (4 species), spore density ( 162/150 gram soil), colonization percentage (high category), and plant diversity (6 species). The plant diversity was decreasing along with the low diversity and abundance of AMF. This results indicate that indigenous AMF can colonizes and promote plant diversity in tailing and potentially can be used to promote revegetation. Elevated C seems play role in enchancing AMF colonization but in soil with low available nitrogen, AMF are indicated to promote carbon loss. Furthermore, higher temperature may result in lower glomalin, protein produced by AMF which function in water-stability of soil aggregate.
Nicotine and Inflammatory Disease in Humans: A Systematic Review
Authors: Price Leonie , Thompson Keith , Martinez Javier 
Published: April 2022

Summary

Introduction
Previous studies have shown that nicotine interacts in inflammatory pathways and may have both pro- and anti-inflammatory actions. The aim of this study was to carry out a systematic review of publications investigating the inflammatory effects of nicotine in models of human disease.

Methods
The Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) checklists were followed during the design and implementation of this study. Searches were carried out across PubMed, Science Direct, and the Cochrane Library. Articles were included if they were published in English, in peer-reviewed journals, reported an effect of nicotine in the treatment of a clinical condition, experimental studies or clinical trials which investigated an effect of nicotine administration in patients with a clinical condition or epidemiological studies which investigated an effect of nicotine administration in patients with a clinical condition.

Results
Thirty-eight studies were identified and categorized into disease areas before systematic review. Nineteen studies were related to digestive diseases (primarily Crohn’s disease and ulcerative colitis), six to atherosclerosis, five to skin and healing, four to pain and infection, three to pulmonary sarcoidosis, and three to multiple sclerosis (one study reported data on three disease areas). Risk of bias assessment was not carried out, but the general quality of the studies was low, mostly offering preliminary data in small numbers of participants. No consistent effects of nicotine treatment (primarily through use of transdermal nicotine patches or nicotine chewing gums) were reported across any of the disease models.

Conclusion
No reliable evidence of a pro- or anti-inflammatory effect of nicotine was observed in patients with any of the diseases included in this study.
Toxicity of Tioxazafen to Meloidogyne incognita and Rotylenchulus reniformis
Authors: Faske Travis R. , Brown Katherine , Kelly Jesse 
Published: April 2022

Abstract
Tioxazafen is a seed-applied nematicide used in row crops. Currently, there are no data on nematode toxicity, nematode recovery, or effects of low concentrations of tioxazafen on nematode infection of a host root for Meloidogyne incognita or Rotylenchulus reniformis. Nematode toxicity and recovery experiments were conducted in water solutions of tioxazafen, while root infection assays were conducted on tomato. Nematode paralysis was observed after 24 hr of exposure at 27.0 µg/ml tioxazafen for both the nematode species. Based on an assay of nematode motility, 24-hr EC50 values of 57.69 µg/ml and 59.64 µg/ml tioxazafen were calculated for M. incognita and R. reniformis, respectively. Tioxazafen rates of 2.7 µg/ml and 27.0 µg/ml reduced the nematode hatch after 3 d of exposure for both the nematode species. There was no recovery in nematode motility after the 24-hr exposure of M. incognita and R. reniformis to their corresponding 48-hr EC50 values of 47.15 µg/ml and 47.25 µg/ml tioxazafen, respectively. Mortality of M. incognita continued to increase after 24 hr exposure, whereas R. reniformis mortality remain unchanged after nematodes were rinsed and removed for 48 hr from the tioxazafen solution. A 24-hr exposure to low concentrations of 0.38 to 47.15 µg/ml for M. incognita and 47.25 µg/ml for R. reniformis reduced the infectivity of each nematode species on tomato roots. The toxicity of tioxazafen was similar between nematode species; however, a greater rate of tioxazafen was needed to suppress R. reniformis infection of tomato than for M. incognita.
Maturidade fisiológica de sementes de Angico Vermelho em função do padrão de desenvolvimento de frutos
Authors: Martins Gleica Maria Correia , Neves Jhonatan David Santos das , Santos Gilcilene Martins , Souza Neto Pregentino Severino de , Albuquerque Kênia Almeida Diniz , Silva Ricardo Barros 
Published: April 2022

Esse estudo objetivou analisar a maturidade fisiológica de sementes de Angico Vermelho (Anadenanthera colubrina Vell.) em função do desenvolvimento de frutos, a fim de determinar o momento ideal a ser realizada a coleta dos frutos. Os frutos utilizados no estudo foram coletados em árvores nos municípios de Jacaré dos Homes e Monteirópolis, no Sertão de Alagoas. Adotou-se o delineamento estatístico inteiramente casualizado, com quatro repetições contendo 50 sementes cada. Os frutos foram classificados em cinco estádios (tratamentos) de acordo com a coloração da vagem: estádio 1 (esverdeado), estádio 2 (verde/amarelo), estádio 3 (verde/vermelho), o estádio 4 (vermelho/vinho) e o estádio 5 (marrom escuro). Foram avaliadas as variáveis: largura (cm), espessura (mm), comprimento (cm) e matéria seca (g) de 100 sementes em cada estádio de maturação, e teor de umidade de sementes (%). Através de teste de germinação se verificou o índice de velocidade de germinação, porcentagem de germinação, percentual de sementes mortas e o tempo médio de germinação. Os dados foram submetidos à análise de variância e as variáveis significativas pelo teste F tiveram suas médias comparadas pelo teste de Tukey (p<0,05). De maneira geral, frutos de angico devem ser coletados quando no estádio 5 de maturidade, pois nesse estádio as sementes atingem a maturidade fisiológica e estão aptas a germinarem.
Incidencia del agua de criaderos de tilapia en el riego del cultivo de maíz (Zea mayz, L.) en El Triunfo, Guayas
Authors: Correa Castro Gabriel Iván , Fajardo Espinoza Paola Gabriela , Flores Cadena Cristian Andrés , Navarrete Cornejo Alexandra Aracely 
Published: April 2022

El maíz en el Ecuador es una de las especies que se cultivan a nivel nacional (costa, sierra, oriente y galápagos), por lo que es considerado uno de los productos agrícola más importantes, de ahí que la investigación se planteó determinar la influencia de cuatro niveles con agua residual de criadero de tilapia en el crecimiento y desarrollo del maíz (Zea mayz, L.) en el Cantón El Triunfo, Guayas, además de establecer la influencia de los tratamientos de agua residual de criadero de tilapia en el desarrollo y productividad del maíz y por ultimo obtener los costos de producción por hectárea en base a la relación beneficio – costo, la investigación fue de tipo Experimental, porque se evaluó diferentes fechas de recambio del agua de criaderos de tilapia aplicadas en cultivo de maíz, la metodología utilizada fue de análisis y síntesis así como inductiva y deductiva el diseño utilizado de bloques completamente al azar con 4 tratamientos y 5 repeticiones las comparaciones de medias de los tratamientos en estudio se los realizaron mediante la prueba de rangos múltiples de Tukey al 5% de probabilidad, entre las variables analizadas altura de planta, Diámetro y Longitud de la mazorca, número de granos por mazorca, peso de 100 granos, peso de la tusa y análisis de agua y del suelo donde se cultivó el maíz la variable número de granos observándose que el tratamiento dos con agua de criadero de tilapia a los 40 días con 478,88 granos en mazorca, en relación al testigo con 451,58 granos.
Canadian Constitution Needs to Be Amended for Canada to Fully Embrace Multiculturalism
Authors: Kim Tina 
Published: April 2022

Reform is needed in the Canadian Charter of Rights and Freedoms to remove Section 16 that recognizes French and English as the two official languages. This clause is problematic as bilingualism is not consistent with the goals of multiculturalism. I argue first that bilingualism violates Section 15, which guarantees formal and substantive equality, as it creates a cultural and linguistic hierarchy. Secondly, I argue how bilingualism violates Section 2, specifically the freedom to choose the language to express themselves. I counter-argue my position and state that even if Canada removes Section 16, it is not substantial to protect the fundamental rights of marginalized citizens living in Quebec as Quebec can utilize Section 33 to override the Court. I respond to this perspective and conclude that removing Section 16 remains necessary to equalize the judicial powers of provinces and for Canada to advance forward with Indigenous reconciliation.