bluuebunny/crossref_metadata_2025_split huggingface dataset:
Auto y heteroestereotipo étnico en estudiantes preuniversitarios de Lima Metropolitana
Authors: Zornoza Carmen 
Published: March 2022

La autora revisa algunas de las investigaciones hechas en el Perú acerca de la influencia de factores étnicos. Luego expone los resultados de una investigación acerca de auto y hetero estereotipos en grupos raciales diferentes. Queda demostrado que el auto estereotipo de los blancos es más alto que el de los mestizos y que el hetero estereotipo de estos últimos es más alto que el de los primeros.
Un estudio de resentimiento en ancianos institucionalizados
Authors: Gazzolo D. Dante , Romero Alvarez Cecilia , León Ramón , Aldana N. Carlos 
Published: March 2022

El presente estudio es una investigación realizada por los Servicios de Psicología del Instituto Nacional de Salud Mental "Honorio Delgado - Hideyo Noguchi", y del Hogar "lgnacia Rodulfa V da. de Canevaro", a través del cual se intenta un acercamiento al devenir psicológico del anciano institucionalizado. Este, al residir permanentemente al interior de un asilo, manifiesta sentimientos de frustración, fracaso y resentimiento, entre otros. Se intenta determinar el grado de: resentimiento que se hace presente en ancianos institucionalizados, tomando en cuenta variables diferenciadoras como condición de vivienda (nivel socio-económico), sexo, edad, estado civil, grado de instrucción, actividad laboral, presencia o ausencia de hijos, y tiempo de residencia en el asilo.Para tal fin, se evaluó a una muestra de 53 ancianos, 32 mujeres y 21 hombres, 18 de nivel socio-económico alto, y 35 de nivel socio-económico bajo, a través de un Inventario de Actitudes hacia la Vida, encontrando que los sujetos de nivel socio-económico bajo presentan mayores grados de resentimiento que los sujetos de nivel socio-económico alto, observándose, de otro lado, mayores niveles de resentimiento en el sexo masculino que en el femenino.
The Effects of Different Undergrowth Vegetation on the Types and Densities of Functional Ground-Dwelling Arthropods in Citrus Orchards
Authors: Inagaki Hidehiro , Yuto Saruta , Daiki Yoto 
Published: March 2022

<p>In agricultural lands, citrus orchards, pest feeding and weed seed predation by ground-dwelling arthropods are essential ecosystem services. This research aims to investigate the effects of different undergrowth vegetation, including weed area, bare land, rattail fescue and white clover fields, on the types and densities of functional ground-dwelling arthropods in citrus orchards, using pitfall traps. The captured organisms included carnivorous beetles (<em>Pheropsophus jessoensis</em>,<em> Chlaenius naeviger</em> and <em>Dolichus halensis</em>), wolf spiders (<em>Lycosidae</em> sp.), earwigs (<em>Anisolabididae</em> sp.), house centipedes (<em>Scutigeromorpha</em> sp.), herbivorous ground beetles (<em>Amara</em> sp., <em>Harpalinae</em> sp.), crickets and millipedes. Furthermore, the population of the functional ground-dwelling arthropods was significantly increased by the presence of a live mulch, where a higher number was seen in the rattail fescue or white clover compared to the weed or bare land fields. The cover crops also affected the types of arthropods identified, with the rattail fescue field including more <em>Pheropsophus jessoensis</em> while the white clover had an elevated number of wolf spiders, earwigs and <em>Amara sp. </em>(a weed seed predator). This discovery indicates that the type of undergrowth vegetation plays an important role in enhancing functional biodiversity. The kind of pests and weeds that these arthropods are effective against, as well as the extent to which their densities can be decreased, is also unknown. Therefore, further research on the feeding habit and predation of these arthropods should be conducted.</p>
Aftereffects in the Transient Electromagnetic Method: Magnetic Viscosity
Authors: Kozhevnikov N.O. , Antonov E.Yu. 
Published: March 2022

Abstract
One of the aftereffects inherent in geological materials is magnetic viscosity. This phenomenon consists in the time lag of changes in magnetic characteristics in relation to changes in the external magnetic field. In rocks, magnetic viscosity is mainly associated with magnetization of superparamagnetic particles. In the transient electromagnetic method, magnetic viscosity is manifested as a slowly decreasing voltage induced in a receiving loop, or, in some cases, as a nonmonotone transient voltage response. Eddy currents and viscous magnetization establish and decay independently; therefore, the induction transient response measured with a fixed-geometry TEM array gives no way of finding the vertical distribution of magnetic viscosity. In order to find it, geometric soundings are needed. At later times, the voltage induced in the receiving loop due to the magnetization decay is vastly larger than that induced by the eddy currents. Because of this, magnetic viscosity contribution to the total transient response limits the sounding depth of the transient electromagnetic method.
Safety of AFM11 in the treatment of patients with B-cell malignancies: Findings from two phase 1 studies
Authors: Topp Max , Dlugosz-Danecka Monika , Skotnicki Aleksander B , Salogub Galina , Viardot Andreas , Klein Andreas K , Hess Georg , Michel Christian S , Grosicki Sebastian , Gural Alex , Schwarz Sylvia , Pietzko Kerstin , Gärtner Ulrike , Strassz András , Alland Leila , Mayer Jiri 
Published: March 2022

Abstract
BackgroundThe prognosis for patients with relapsed and/or refractory (R/R) non-Hodgkin’s lymphoma (NHL) or acute lymphoblastic leukaemia (ALL) remains poor, with existing treatments having significant side effects. Developed for the treatment of these cancers, AFM11 is a tetravalent, bispecific humanised recombinant antibody construct (TandAb®) designed to bind to human CD19 and CD3 and lead to the activation of T cells inducing apoptosis and killing of malignant B cells.MethodsTwo open-label, multicentre, dose-escalation phase 1 studies evaluated the safety, pharmacokinetics and activity of AFM11 in patients with R/R CD19-positive B cell NHL (AFM11-101) and in patients with CD19+ B-precursor Philadelphia-chromosome negative ALL (AFM11-102). Adverse events (AEs) were assessed and recorded, imaging (NHL) or bone marrow assessment (ALL) were used to evaluate response. Additional pharmacodynamic assays undertaken included cytokine release analysis, B-cell and T-cell depletion.ResultsIn AFM11-101, 16 patients with R/R NHL received AFM11 in five different dose cohorts. Of which, 14 experienced drug-related treatment-emergent AEs (TEAEs) [including five serious AEs (SAEs)], five patients experienced dose-limiting toxicity (DLT) and ten patients discontinued the study. The high number of neurological events led to a decrease in infusion frequency during the study. No objective response to treatment was observed. In AFM11-102, 17 patients with R/R ALL received AFM11 in six different dose cohorts. Thirteen patients experienced drug-related TEAEs (including four SAEs), DLTs occurred in two patients and five patients discontinued the study. An objective response was recorded in three patients. The maximum tolerated dose could not be determined in either study due to early termination.ConclusionsAFM11 treatment was associated with frequent neurological adverse reactions that were severe in some patients. In ALL some signs of activity, albeit short lived, were observed whereas no activity was observed in patients with NHL; therefore, further clinical development was terminated.Trial IdentifiersNCT02106091, NCT02848911
Profiling target engagement and cellular uptake of cRGD-decorated clinical-stage core-crosslinked polymeric micelles
Authors: De Lorenzi Federica , Rizzo Larissa Yokota , Daware Rasika , Motta Alessandro , Baues Maike , Bartneck Matthias , Vogt Michael , Zandvoort Marc van , Kaps Leonard , Hu Qizhi , Thewissen Marielle , Casettari Luca , Rijcken Cristianne J.F. , Kiessling Fabian , Sofias Alexandros Marios , Lammers Twan 
Published: March 2022

Abstract
Polymeric micelles are increasingly explored for tumor-targeted drug delivery. CriPec® technology enables the generation of core-crosslinked polymeric micelles (CCPM) based on thermosensitive (mPEG-b-pHPMAmLacn) block copolymers, with high drug loading capacity, tailorable size, and controlled drug release kinetics. In this study, we decorated clinical-stage CCPM with the αvβ3 integrin-targeted cyclic arginine-glycine-aspartic acid (cRGD) peptide, which is one of the most well-known active targeting ligands evaluated preclinically and clinically. Using a panel of cell lines with different expression levels of the αvβ3 integrin receptor and exploring both static and dynamic incubation conditions, we studied the benefit of decorating CCPM with different densities of cRGD. We show that incubation time and temperature, as well as the expression levels of αvβ3 integrin by target cells, positively influence cRGD-CCPM uptake, as demonstated by immunofluorescence staining and fluorescence microscopy. We demonstrate that even very low decoration densities (i.e., 1 mol % cRGD) result in higher engagement and uptake by target cells as compared to peptide-free control CCPM, and that high cRGD decoration densities do not result in a proportional increase in internalization. In this context, it should be kept in mind that a more extensive presence of targeting ligands on the surface of nanomedicines may affect their pharmacokinetic and biodistribution profile. Thus, we suggest a relatively low cRGD decoration density as most suitable for in vivo application.
Optimal allocation of water resources with dual water environmental carrying capacity constraints of water quantity and quality based on multi-scenario analysis
Authors: Fu Zhenghui , Zhang Yang , Wang Han , Jiang Xia , Wang Shuhang 
Published: March 2022

Abstract
Multiple dilemmas under the interaction of water quantity and water quality have become the primary problem of water resources allocation. The effects of climate change are also exacerbating uncertainty in the system. To overcome the uncertainty and coupling in regional water resources planning management, a comprehensive framework through integrated with interval fuzzy program, water quality model and water resources quantity model has been developed to obtain the “optimal” solution in this study. The model is a hybrid methodology of interval parameter programming (IPP), fuzzy programing (FP), a general one-dimensional water quality model and the Tennant method. The multiple scenario analysis has been conducted under different representative concentration paths (RCPs). The results suggested that the methodology was applicable for reflecting the complexities of the regional water resources planning and management systems within the planning period. The total regional water availability and water environmental capacity under the impact of climate change will be obtained. Furthermore, the decision-maker can obtain the reasonable allocation of limited water resources in different regions and different users, so as to achieve the sustainable utilization of water resources and the development of regional economy.
Evaluation of the effectiveness of topical oily lotion containing frankincense extract in the treatment of knee osteoarthritis: a randomized, double-blind, placebo controlled clinical trial
Authors: Mohsenzadeh Afsaneh , Karimifar Mansoor , Soltani Rasool , Hajhashemi Valiollah 
Published: March 2022

Abstract
Objective: Pharmacological treatments of osteoarthritis have several side effects. Boswellia serrata resin (frankincense) is rich in boswellic acids that have antioxidant and anti-inflammatory effects; though, their oral bioavailability is low. The aim of this study was evaluation of the clinical effectiveness of frankincense extract in the treatment of knee OA. In a randomized double-blind placebo-controlled clinical trial, eligible patients with knee OA were randomly divided into two groups of drug (33 patients) and control (37 patients), to use oily lotion of frankincense extract or placebo, respectively, on the involved knee three times daily for four weeks. WOMAC (Western Ontario and McMaster Universities Osteoarthritis Index), VAS (visual analogue scale; for pain severity), and PGA (patient global assessment) scores were determined before and after intervention.Results: For all evaluated outcome variables, there was a significant decrease from baseline in both groups (P < 0.001 for all). Furthermore, the end-of-intervention values for all parameters were significantly lower in drug group than placebo group (P < 0.001 for all), showing more effectiveness of drug compared to placebo. Topical oily lotion containing enriched extract of boswellic acids could decrease pain severity and improve the function in patients with knee OA.Trial RegistrationTrial registration number: IRCT20150721023282N14Trial registration date: September 20, 2020
Spontaneous correction of scoliosis after curettage of spinal osteoid osteoma: how and when?
Authors: Pan Xiyu , Qiao Jun , Liu Zhen , Shi Benlong , Mao Saihu , Li Song , Sun Xu , Zhu Zezhang 
Published: March 2022

Abstract
Background: Scoliosis behavior after curettage of spinal osteoid osteoma has been not clarified as most studies regarding scoliosis secondary to osteoid osteoma (OO) were case reports. The aims of this study were to investigate (1) clinical and radiographic features of scoliosis secondary to OO; (2) scoliosis behavior after Curettage of OO. Methods: A retrospective study was performed at patients who were diagnosed as OO clinically or pathologically from July 1998 to December 2019 in a single institution. Age, gender, location of pain, location of lesion and curve pattern of scoliosis were collected preoperatively. Intraoperative blood loss, operation time and surgical complications were documented. VAS scores and curve magnitude were collected pre- and postoperatively and at last follow-up.Results: The mean operation time was 124±32 min and the average intraoperative blood loss was 274±134 ml. The mean preoperative VAS score was 6.2±2.7 , and the mean postoperative VAS score was 2.1±1.8 . Thoracic scoliosis was improved from 22.7±10.6°to 6.2±4.3°after operation，and to 4.1±4.3° at last follow-up. Lumbar scoliosis was improved from 18.1±7.4° to 6.7±5.2°after operation，and to 5.3±3.9°at last follow-up. Trunk shift was improved from 34.7±12.4mm to 10.5±7.2mm after operation，and to 8.4±5.6mm at last follow-up. There was no significant differences as to sagittal radiographic parameters (P＞0.05).Conclusion: Patients with spinal OO had a significantly high incidence of scoliosis. Patients could get rapid relief of pain and scoliosis with low occurrence. Night pain, pain at the concave side of curve, normal sagittal alignment could help differentiate it from scoliosis associated with lumbar disc herniation.
Morality in Deceptive Environments: The puzzling effects of deceptive culture on moral behavior
Authors: Mitkidis Panagiotis , Gerlach Philipp , Nichols Aaron , Elbaek Christian , Perkovic Sonja , Ariely Dan 
Published: March 2022

Abstract
Psychologists, economists, and philosophers as well as lay people have long argued and intuited that in environments where deception is normative, moral behavior is harmed. After we confirmed this folk intuition, we challenge it and show that individuals making decisions within deceptive environments do not behave more dishonestly than in nondeceptive environments. We demonstrate the latter utilizing an example of experimental deception within established institutions, such as laboratories and institutional review boards. Specifically, we first find correlational evidence showing that experiencing deception at the laboratory level yields lower dishonesty. Then, across three studies, we empirically demonstrate that deceptive environments do not affect downstream honest behavior but that when participants were in a deceptive environment and aware of being observed, their dishonest behavior decreased. Our results show that the relationship between deception and dishonesty is more complicated than previous interpretations have suggested and expand the understanding of deception and moral behavior.
Disordered eating in early childhood: DRD4 and DAT1 gene polymorphisms and quality of mother-child interaction
Authors: Pascale Esterina , Cimino Silvia , Cerniglia Luca , Bevilacqua Arturo 
Published: March 2022

Abstract
Purpose. Eating disorders are complex heritable conditions that can be influenced by both genetic and environmental factors but are poorly studied in early development. The aim of this research was to investigate the association of genetic polymorphisms within dopaminergic pathways with early eating disorders.Methods. We analyzed the presence of VNTR polymorphisms of DRD4 (rs1805186) and DAT1 (rs28363170) in overeating (N=45), undereating (N=48) and control (N=44) young children. We also assessed presence of externalizing, internalizing and dysregulation symptoms by the Child Behavior Checklist and quality of mother-child interactions during feeding by the Italian adaptation of the Scale for the Assessment of Feeding Interaction, respectively.Results. Both polymorphisms were associated with children’s eating behavior, psychological symptoms and quality of interaction with their mothers, suggesting that: a) the DRD4 4-repeat allele behaves as a protective factor, the 2-repeats and 7-repeats alleles as risk factors, for undereating behavior, the general quality of mother-child interaction and internalizing, externalizing and dysregulated symptoms; and b) the DAT1 9-repeats allele behaves as a protective factor, the 10-repeats allele as a risk factor, for overeating behavior, the general quality of mother-child interaction, internalizing, externalizing and dysregulated symptoms;. Finally a gene x gene interaction is suggested between the DAT1 9-repeat or 10-repeat allele and the DRD4 4-repeat allele.Conclusions. Our results suggest a role for DRD4 and DAT1 in an early susceptibility to eating disorders.Level of evidence III: Evidence obtained from well-designed case-control analytic study.
Intraindividual Variability in Daily Experiences of Posttraumatic Growth, Affect, and HIV/AIDS Stigma among People Living with HIV: Does Resilience Matter?
Authors: Pięta Małgorzata , Rzeszutek Marcin 
Published: March 2022

Abstract
This study investigated intraindividual variability in daily posttraumatic growth (PTG) versus posttraumatic depreciation (PTD), positive and negative affect (PA and NA), and HIV/AIDS stigma among people living with HIV (PLWH). Additionally, we examined whether this variability may derive from participants’ resilience. The participants included 67 PLWH who after filling the baseline questionnaire on resilience for five consecutive days they completed short versions of questionnaire on (PTG/ PTD), daily declared affect, as well as daily HIV/AIDS stigma. We observed significant intraindividual variability in PTG, PTD, PA, NA, and perceived stigma. Resilience was related to PTG, PTD, PA, and NA but not stigma. Moreover, higher resilience was associated with higher, stabler PA and lower, stabler NA. Our results show the need for better PTG operationalization and measurement, particularly regarding daily manifestations in real life and intraindividual variability, as well as further studies on PLWH’s daily functioning in various areas.
Primary versus Staged Repair of Isolated Ventricular Septal Defect in Symptomatic Infants Less Than 3 Months of Age
Authors: ElDerie Ahmad , Abdelbaser Ibrahim , Hassan Walid , Sanad Mohammed , Awad Gehad 
Published: March 2022

Abstract
Background
Interventricular septum defects (VSD) constitute the second most common cardiac anomaly. Large defects carry significant clinical compromise in early infancy. Surgical approach is multifactorial and is not yet a matter of consensus in symptomatic patients below 3 months of age.
Methods
We reviewed cases who had primary closure or pulmonary artery banding under the age of 3 months for an isolated VSD at our institution from January 2019 to January 2021. Patients were allocated to the palliative and repair groups. Operative mortality, duration of inotropic support, mechanical ventilation and length of Intensive care (ICU) stay were compared.
Results
Included were 19 patients. Eight patients (42.1%) had pulmonary artery banding, and 11 (57.9%) had definitive repair. No operative mortality was recorded. No difference of statistical significance was noted regarding durations of inotropic support, mechanical ventilation or ICU stay (p = 0.845, p = 0.903, and p = 0.728, respectively). Body surface area was lower in the palliative group (p = 0.027).
Conclusion
Primary surgical closure of the VSD in symptomatic infants younger than three-month age can be done safely in the current era and eliminates the PAB (pulmonary banding)-related morbidity. However, PAB can be still applied in certain patients who are not candidate for open cardiac surgery.
Mn-porphyrins Anchored onto Magnetic Nanoparticles via Different Linker Length: A Comparative Study in Aerobic Oxidation of Olefins
Authors: Rayati Saeed , Shokoohi Saeedeh 
Published: March 2022

Abstract
In this research, meso-tetrakis(4-carboxyphenyl)porphyrinatomanganese(III) acetate has been immobilized onto the modified silica-coated Fe3O4 nanoparticles with linkers with different chain lengths (short, Fe3O4@SiO2-MnTCPP (C-1), medium Fe3O4@SiO2-NH2-MnTCPP (C-2), and long length, Fe3O4@SiO2-NHCO-NH2-MnTCPP (C-3)). The catalysts were characterized by various analytical and spectroscopic methods, including FT-IR, UV-Vis, XRD, FE-SEM, TEM, TGA, and VSM. A comparative study based on the difference in chain length of the linker in the oxidation of olefins with molecular oxygen was performed. The novel linker (long-chain catalyst) was designed to improve the performance of the catalytic activity (complete conversion of the α-methyl styrene, 4-methyl styrene and 4-chloro styrene was achieved after 2 h). The new heterogenized catalyst (Fe3O4@SiO2-NHCO-NH2-MnTCPP) not only shows higher catalytic activity in the oxidation of different olefins, but also shows better reusability of the catalyst.
The effect of early versus delayed tumor specific therapy on survival in patients with lung cancer: a retrospective study of 375 cases
Authors: Geiken Rike , Reyners Ann , Griesinger Frank , Otremba Burkhart , Hoheisel Michael , Bäsecke Jörg 
Published: March 2022

Abstract
Background
The timing of tumor specific palliative therapy and its influence on the survival of patients with stage IV lung cancer remains unclear.
Methods
375 patients with UICC stage IV lung cancer who experienced an early or delayed therapy (early or delayed therapy group; TG) were investigated using histology and ECOG performance score-related subgroups. Kaplan-Meier and Cox regression analyses were used for survival analyses.
Results
Patients in the early TG had a significantly shorter median overall survival than those in the delayed TG (6 vs. 11 months). Patients with an ECOG-PS of ≥ 1 were significantly more present in the early than in the delayed TG (66.8% vs. 51.9%). But an early therapy was also significantly associated to a shorter median OS in ECOG-matched subgroups (ECOG-PS of 0; 7 vs. 23 months, ECOG ≥ 1 ; 6 vs. 8 months). An early therapy was associated to a significantly worse median OS in histological subgroups (NSCLC; 5 vs. 11 months, SCLC; 7 vs. 11 months) and was an independent risk factor in uni- and multivariate analyses.
Conclusions
An early initiation of cancer specific therapy was associated with a shorter survival time in palliative lung cancer patients, independent of the ECOG-PS and histological subtype.