bluuebunny/crossref_metadata_2025_split huggingface dataset:
Deletion ofTRPC6, an autism risk gene, induces hyperexcitability in cortical neurons derived from human pluripotent stem cells
Authors: Shin Kyung Chul , Ali Gowher , Ali Moussa Houda Yasmine , Gupta Vijay , de la Fuente Alberto , Kim Hyung-Goo , Stanton Lawrence W , Park Yongsoo 
Published: November 2022

ABSTRACTAutism spectrum disorder (ASD) is a complex and heterogeneous neurodevelopmental disorder linked to numerous rare, inherited and arisingde novogenetic variants. ASD often co-occurs with attention-deficit hyperactivity disorder and epilepsy, which are associated with hyperexcitability of neurons. However, the physiological and molecular mechanisms underlying hyperexcitability in ASD remain poorly understood. Transient receptor potential canonical-6 (TRPC6) is a Ca2+-permeable cation channel that regulates store-operated calcium entry (SOCE) and is a candidate risk gene for ASD. Using human pluripotent stem cell (hPSC)-derived cortical neurons, single cell calcium imaging, and electrophysiological recording, we show that TRPC6 knockout (KO) reduces SOCE signaling and leads to hyperexcitability of neurons by increasing action potential frequency and network burst frequency. Our data provide evidence that reduction of SOCE by TRPC6 KO results in neuronal hyperexcitability, which we hypothesize is an important contributor to the cellular pathophysiology underlying hyperactivity in some ASD.
Deciphering divergent trypanosomatid nuclear complexes by analyzing interactomic datasets with AlphaFold2 and genetic approaches
Authors: Araya Elvio Rodriguez , Merli Marcelo L. , Cribb Pamela , de Souza Vinicius C. , Serra Esteban 
Published: November 2022

AbstractAcetylation signaling pathways in trypanosomatids, a group of early branching organisms, are poorly understood due to highly divergent protein sequences. To overcome this challenge, we used interactomic datasets and AlphaFold2-multimer to predict direct interactions and validated them using yeast two and three-hybrid assays. We focused on MRG domain-containing proteins and their interactions, typically found in histone acetyltransferase/deacetylase complexes. The results identified a structurally conserved complex,TcTINTIN, which is orthologous to human and yeast TINTIN complexes; and another trimeric complex involving an MRG domain, only seen in trypanosomatids. The identification of a key component ofTcTINTIN,TcMRGBP, would not have been possible through traditional homology-based methods. We also conducted molecular dynamics simulations, revealing a conformational change that potentially affects its affinity forTcBDF6. The study also revealed a novel way in which an MRG domain participates in simultaneous interactions with two MRG binding proteins binding two different surfaces, a phenomenon not previously reported. Overall, this study demonstrates the potential of using AlphaFold2-processed interactomic datasets to identify protein complexes in deeply branched eukaryotes, which can be challenging to study based on sequence similarity. The findings provide new insights into the acetylation signaling pathways in trypanosomatids, specifically highlighting the importance of MRG domain-containing proteins in forming complexes, which may have important implications for understanding the biology of these organisms and developing new therapeutics. On the other hand, our validation of AlphaFold2 models for the determination of multiprotein complexes illuminates the power of using such artificial intelligence-derived tools in the future development of biology.Abstract Figure
BIM-based analysis of construction safety tracking using behavior-based safety in Bangladeshi construction industry
Authors: Meem Tamanna Islam , Hossain Md. Mehrab , Akter Jhumana 
Published: November 2022

PurposeIn comparison to other industries, the construction industry is one of the most dangerous industries. Behavior-based safety (BBS) is a common and useful technique for risk indicator processing. Almost all studies are based on the BBS checklist, but very few of them focus on the increasing dangers faced by construction workers and the important factors that lead to accidents. This research represents a risk spatiotemporal analysis and visual tracking approach based on BBS and Building Information Modeling (BIM).Design/methodology/approachAfter the literature review, a BBS checklist was developed. Then a survey was conducted based on the BBS checklist and the temporal evolution of risks has been completed. After that, managing the risk with the automatic rule checking (ARC) system using BIM was conducted simultaneously to develop a framework by conducting a case study.FindingsBased on the grey clustering analysis, this work provides a temporal evolution analysis approach for dynamic analyzing BBS risk. According to the grey relational analysis (GRA) data, the main key factor of risk was the missing guardrail/handrail system. After that, a case study was performed and the system automatically warn in the preconstruction phase that the barrier is missing as the system benefits.Originality/valueA systematic framework has been provided for risk analysis through which high health and safety performance outcomes can be achieved on construction projects. This study will assist design engineers in addressing the potential danger to employees during the preconstruction stage and monitoring dynamic changes in risk on any construction site.
Transport infrastructure and manufacturing sector: an energy perspective from India
Authors: Shameem P. Mohammed , Chittedi Krishna Reddy , Villanthenkodath Muhammed Ashiq 
Published: November 2022

Purpose
The purpose of this study is to dissect the transport infrastructure performance, public spending in transport infrastructure development and the manufacturing sector in determining the transport sector energy consumption.

Design/methodology/approach
An analysis of transport energy consumption with the transport infrastructure performance, public spending in transport infrastructure and manufacturing sector output in India using annual data for the period 1987–2019. The study used the autoregressive distributed lag (ARDL) bounds test approach along with FMOLS, DOLS and canonical cointegration regression (CCR) methods.

Findings
The results of the ARDL bounds test provide evidence for the long- and short-run relationships among study variables. It evidenced that transport infrastructure performance reduces transport energy consumption by using FMOLS, DOLS and CCR methods. Furthermore, the inference of the positive impact of value added in the manufacturing sector on transport energy consumption validates the higher energy demand of the manufacturing sector from a mobility perspective.

Practical implications
The estimated finding of this study is expected to be contributing to policy-making discussions on transport infrastructure and manufacturing sector development in an emerging economy like India with insights on energy consumption.

Originality/value
To the best of the authors’ knowledge, this is the first study that integrates the impact of manufacturing sector output on transport sector energy consumption along with transport infrastructure performance and public investment in the transport infrastructure.
Service quality scale development for fully automatic operation metro system
Authors: He Zhen , Hu Hao , Zhang Min , Qin Fang 
Published: November 2022

Purpose
Fully automatic operation (FAO) metro system is the trend of urban rail in modern cities. This study aims to develop a service quality scale for measuring passenger service perception in the context of FAO metro system.

Design/methodology/approach
Based on the interviews and the dimensions proposed in the previous service quality scales of the public transport sector, this study develops a multidimension service quality scale. Face-to-face interviews and surveys are conducted to obtain the riding experience and satisfaction of passengers in the metro stations of Beijing Subway Yanfang Line and Beijing Daxing International Airport Express that are FAO metro lines. Reliability, validity and nomological validity of our scale are demonstrated.

Findings
Six dimensions (i.e. tangibles, information, safety, efficiency, empathy and innovation) and 22 items are included in the scale through quantitative analysis. It is found that all of the six dimensions have a significant relationship with passenger satisfaction. Especially information and innovation are the more important dimensions of FAO metro system service quality.

Originality/value
This study contributes to the service quality literature in the public transport sector taking the FAO metro system as the object. The findings may provide a guide for the FAO metro operators to evaluate and improve their service quality.
Consumer satisfaction with local rice attributes and willingness to pay for improvement by internal migrants and natives in urban Ghana
Authors: Amfo Bismark , Abankwah Vincent , Tanko Mohammed 
Published: November 2022

PurposeThis study investigated consumers' satisfaction with local rice attributes and willingness to pay (WTP) for improvement by internal migrants and natives in urban Ghana.Design/methodology/approachPrimary data was sourced from 304 urban consumers and ordered probit regression was employed.FindingsUrban consumers had higher satisfaction with imported rice attributes than local rice. Consumers were unsatisfied with aroma, availability/accessibility, cleanliness, packaging, grain appearance, measurement standard, and taste of local rice. Moreover, 90% were willing to pay higher prices for local rice with improved attributes and WTP was higher among natives than migrants. Averagely, urban consumers are willing to pay 51% increase in market price of local rice if attributes were improved. Natives, males, educated, high-income, local rice consumption, shopping from supermarkets, trust in certification bodies, and dissatisfaction with local rice attributes boost WTP for improved local rice attributes.Research limitations/implicationsThere is a great market potential for local rice with improved attributes. Thus, there should be an improvement in local rice attributes and sold at moderate price and in supermarkets.Originality/valueWe compared consumers' satisfaction and WTP for improved local rice attributes among internal migrants and natives in urban Ghana.
Nonlinear vibration response of a helicopter supercritical tail rotor drive shaft equipped with a dry friction damper
Authors: Song Liyao , Chen Bai , Li Bo , Zhu Rupeng , Wang Dan 
Published: November 2022

PurposeThe supercritical design of tail rotor drive shaft has attracted more attention in helicopter design due to its high power–weight ratio and low maintenance cost. However, there exists excessive vibration when the shaft passes through the critical frequency. Dry friction damper is the equipment applied to the drive shaft to suppress the excessive vibration. In order to figure out the damping mechanism of the dry friction damper and improve the damping efficiency, the dynamic model of the shaft/damper system is established based on the Jeffcott rotor model.Design/methodology/approachThe typical frequency response of the system is studied through bifurcation diagrams, amplitude-frequency characteristic curves and waterfall frequency response spectrum. The typical transient responses under frequency sweeps are also obtained.FindingsThe results show that the response of the system changes from periodic no-rub motion to quasi-periodic rub-impact motion, and then to synchronous full annular rub-impact, and finally, back to periodic no-rub motion. The slip of the rub-impact ring improves the stability of the system. Besides, the effects of the system parameters including critical dry friction force, rub-impact friction coefficient, initial clearance on the stability and the vibration damping capacity are studied. It is observed that the stability changes significantly varying the three parameters respectively. The vibration damping capacity is mainly affected by the critical dry friction force and the initial clearance.Originality/valuePresented results provide guidance for the design of the dry friction damper.
Social innovation: relationships with social and human capitals, entrepreneurial competencies and growth of social enterprises in a developing country context
Authors: Pansuwong Wanniwat , Photchanachan Sarana , Thechatakerng Pusanisa 
Published: November 2022

Purpose
This study aims to examine capital and competency variables – human capital, social capital and personal entrepreneurial competencies – in relation to social innovation development and growth of social enterprises in a developing country with an emerging social enterprise sector: Thailand.

Design/methodology/approach
A hypothetical-deductive approach was adopted and a quantitative survey by questionnaire was applied to collect data from owners/top management of 103 social enterprises in Thailand. The data were used to test hypotheses and further analysed using partial least squares technique.

Findings
The results revealed that there were positive direct and indirect (mediating) relationships between human capital, social capital, personal entrepreneurial competencies and social innovation development and growth of Thai social enterprises. Skills and training were key determinants of human capital, whereas social interaction, trust, social identification and shared knowledge were key determinants of social capital which affected social innovation development. Goal orientation, information seeking, opportunity seeking, persuasion and self-confidence were key determinants of entrepreneurial competencies that also affected social innovation development. This study ultimately revealed the mediating effects of social innovation development on the relationships between capital and competency variables and the growth of social enterprises.

Originality/value
This study fills the research gap, from the theoretical perspective, by identifying capital and competency variables as well as their additional determinants that are divergent from previous literature, which can potentially influence the social innovation development of social enterprises, and where only limited research is evidenced. From an empirical perspective, this study attempts to investigate the associations between these variables and growth indicators in the context of social enterprises in a developing nation, where its sector is in its infancy. This study further helps to clarify the existence of the direct and indirect (mediating) effects of social innovation development in the context of the economic and social accomplishments of social enterprises.
Drivers of community assembly change during succession in wood‐decomposing beetle communities
Authors: Seibold Sebastian , Weisser Wolfgang W. , Ambarlı Didem , Gossner Martin M. , Mori Akira S. , Cadotte Marc W. , Hagge Jonas , Bässler Claus , Thorn Simon 
Published: November 2022

Abstract

The patterns of successional change of decomposer communities is unique in that resource availability predictably decreases as decomposition proceeds. Saproxylic (i.e. deadwood‐dependent) beetles are a highly diverse and functionally important decomposer group, and their community composition is affected by both deadwood characteristics and other environmental factors. Understanding how communities change with faunal succession through the decomposition process is important as this process influences terrestrial carbon dynamics.

Here, we evaluate how beta‐diversity of saproxylic beetle communities change with succession, as well as the effects of different major drivers of beta‐diversity, such as deadwood tree species, spatial distance between locations, climate and forest structure.

We studied spatial beta‐diversity (i.e. dissimilarity of species composition between deadwood logs in the same year) of saproxylic beetle communities over 8 years of wood decomposition. Our study included 379 experimental deadwood logs comprising 13 different tree species in 30 forest stands in Germany. We hypothesized that the effects of tree species dissimilarity, measured by phylogenetic distance, and climate on beta‐diversity decrease over time, while the effects of spatial distance between logs and forest structure increase.

Observed beta‐diversity of saproxylic beetle communities increased over time, whereas standardized effects sizes (SES; based on null models) of beta‐diversity decreased indicating higher beta‐diversity than expected during early years. Beta‐diversity increased with increasing phylogenetic distance between tree species and spatial distance among regions, and to a lesser extent with spatial distance within regions and differences in climate and forest structure. Whereas effects of space, climate and forest structure were constant over time, the effect of phylogenetic distance decreased.

Our results show that the strength of the different drivers of saproxylic beetle community beta‐diversity changes along deadwood succession. Beta‐diversity of early decay communities was strongly associated with differences among tree species. Although this effect decreased over time, beta‐diversity remained high throughout succession. Possible explanations for this pattern include differences in decomposition rates and fungal communities between logs or the priority effect of early successional communities. Our results suggest that saproxylic beetle diversity can be enhanced by promoting forests with diverse tree communities and structures.
Populist parties and the two‐dimensional policy space
Authors: HUBER ROBERT A. , JANKOWSKI MICHAEL , JUEN CHRISTINA‐MARIE 
Published: November 2022

AbstractHow are parties' ideological positions and levels of populism connected? Existing research either advocates for a U‐shaped relationship between parties' left‐right position and their degree of populism or uses specific dimensions of a two‐dimensional policy space to describe right‐wing populist parties. We provide an integrated perspective to describe parties' degree of populism by arguing that populism is higher when parties put strong emphasis on a collectivist host ideology. This has implications on how these ideologies relate to the two‐dimensional policy space. Combined with salience of policy dimensions, such a perspective allows for a better understanding of the occurrence of populism among right‐ and left‐wing populist parties. Using expert survey data on parties in Europe, we find strong and robust empirical support for the expected patterns.
Notation, Performance, and the Significance of Print in the Music of Ignatius Sancho (c. 1729–1780)1
Authors: Cypess Rebecca 
Published: November 2022

AbstractThe posthumously published correspondence of the Black British writer, butler, musician, and shopkeeper Ignatius Sancho (c. 1729–1780) has received extensive critical attention in recent decades, especially because it contributed to opening a space for Black authorship in the Atlantic world. Absent from discussions of Sancho's negotiation of orality, writing, and print have been Sancho's books of musical compositions—the volumes published during his lifetime, apparently with his involvement and oversight. Consideration of his instrumental dance music within the context of the genres in which he wrote reveals that he navigated the boundary between orality and print deliberately and meaningfully. His musical notation engages with the sentimental style, and his explicit use of French horns—extremely rare or perhaps unique among eighteenth‐century publications of dance music for small ensembles—refers to the presence of Black musicians in Britain. By engaging with and subverting conventions of musical notation and print, Sancho's music points beyond itself, guiding the reader or listener from the notated scores to the ineffable, transient sounds of the eighteenth‐century Black experience.
Operationalising sustainability? Why sustainability fails as an investment criterion for safeguarding the future
Authors: Friederich Simon , Symons Jonathan 
Published: November 2022

AbstractPolicy instruments promoting sustainability, such as investment taxonomies, are playing an increasing role in guiding the allocation of financial resources internationally. But can policy instruments define sustainability in ways that are both operational (i.e. assessable via replicable procedures) and which specify practices that can reliably be expected to enhance future generations' welfare? This paper analyses candidate definitions of sustainability and identifies a dilemma: while various definitions identify a ‘capital’ variable whose value can indeed be determined empirically; we have no reason to assume that preservation of any specific capital variable will maximise expected future welfare. By contrast, sustainability can be defined ‘dynamically’ in terms of activities that will, on expectation, lead to future developmental trajectories with high welfare. But, as we show through discussion of concrete examples, ‘dynamic sustainability’ cannot readily be operationalised. We conclude that what qualifies as ‘sustainable’ will remain a subject of political dispute and that authoritative comprehensive assessments of ‘sustainability’ will remain chimeric. We suggest that selecting a narrow class of specific measures, such as of life‐cycle greenhouse gas emissions, might lead to more effective and less contentious approaches to resource allocation.
Clinical significance of interstitial lung abnormalities and immune checkpoint inhibitor‐induced interstitial lung disease in patients with non‐small cell lung cancer
Authors: Murata Daiki , Azuma Koichi , Matama Goushi , Zaizen Yoshiaki , Matsuo Norikazu , Murotani Kenta , Tokito Takaaki , Hoshino Tomoaki 
Published: November 2022

AbstractBackgroundInterstitial lung abnormalities (ILAs) are known to be a risk of drug‐induced pneumonitis. However, there are few reports on the relationship between ILAs and immune checkpoint inhibitor‐related interstitial lung disease (ICI‐ILD). We retrospectively investigated the clinical significance of ILAs in patients with non‐small cell lung cancer (NSCLC) receiving ICIs.MethodsWe defined ILAs as nondependent abnormalities affecting more than 5% of any lung zone, including ground‐glass or diffuse centrilobular nodularities, traction bronchiectasis, honeycombing, and nonemphysematous cysts. Early‐onset ICI‐ILD was defined as developing within 3 months after the initiation of ICI administration.ResultsOf 264 patients with advanced NSCLC, 57 patients (21.6%) had ILAs (43 fibrotic and 14 nonfibrotic ILAs). The difference between the incidence of ICI‐ILD in patients with or without ILAs was not significant. Of 193 patients treated by ICI monotherapy, 18 (9.3%) developed early‐onset ICI‐ILD. Among patients receiving ICI monotherapy, the incidence of early‐onset ICI‐ILD was significantly higher in patients with than in patients without nonfibrotic ILAs.ConclusionThe presence of nonfibrotic ILAs is a significant risk for early‐onset ICI‐ILD in patients with NSCLC undergoing ICI monotherapy. Clinicians should be aware of ILAs, especially nonfibrotic ILAs, before administering ICIs to lung cancer patients.