bluuebunny/crossref_metadata_2025_split huggingface dataset:
Automated assessment of immunofixations with deep neural networks
Authors: Thiemann Christian , Klitzke Britta , Martinetz Philipp , Grüning Philipp , Käster Thomas , Barth Erhardt , Kramer Jan , Martinetz Thomas 
Published: August 2022

Abstract

Objectives
The reliable evaluation of immunofixation electrophoresis is part of the laboratory diagnosis of multiple myeloma. Until now, this has been done routinely by the subjective assessment of a qualified laboratory staff member. The possibility of subjective errors and relatively high costs with long staff retention are the challenges of this approach commonly used today.

Methods
Deep Convolutional Neural Networks are applied to the assessment of immunofixation images. In addition to standard monoclonal gammopathies (IgA-Kappa, IgA-Lambda, IgG-Kappa, IgG-Lambda, IgM-Kappa, and IgM-Lambda), also bi- or oligoclonal gammopathies, free chain gammopathies, non-pathological cases, and cases with no clear finding are detected. The assignment to one of these 10 classes comes with a confidence value.

Results
On a test data set with over 4,000 images, approximately 25% of the cases are sorted out as inconclusive or due to low confidence for subsequent manual evaluation. On the remaining 75%, about 3,000 cases, not even one is classified as falsely positive, and only one as falsely negative. The remaining few deviations of the automated assessment from the classifications assigned manually by experts are borderline cases or can be explained otherwise. As a software running on a standard desktop computer, the Deep Convolutional Neural Network needs less than a second for the assessment of an immunofixation image.

Conclusions
Assisting the laboratory expert in the assessment of immunofixation images can be a useful addition to laboratory diagnostics. However, the decision-making authority should always remain with the physician responsible for the findings.
Two isomers Ba5Mg4C54O48H114 and Pb5Mg4C54O48H114
Authors: Fábry Jan , Samolová Erika , Dušek Michal 
Published: August 2022

Abstract
There are reported two related structures of Ba5Mg4C54O48H114 (dodeca(aqua-6κ
3O,7κ
3O,8κ
3O,9κ
3O)-tris(μ2-propanoato-1:6κ
2O,1κO′)-tris(μ-propanoato-2:7κ
2O,2κO′-tris(μ-propanoato-3:8κ
2O,3κO′)-tris(μ-propanoato-4:9κ
2O,4κO′)-hexakis(μ3-propanoato-1:5κ
2O,2:5κ
2O′;1:5κ
2O,3:5κ
2O′;1:5κ
2O,4:5κ
2O′;2:5κ
2O,3:5κ
2O′;2:5κ
2O,4:5κ
2O′;3:5κ
2O,4:5κ
2O′)-pentabarium tetramagnesium), (I), and Pb5Mg4C54O48H114 (dodeca(aqua-1κ
3O,2κ
3O,3κ
3O,4κ
3O)-hexakis(μ3-propanoato-1:5κ
2O,2:5κ
2O′;1:5κ
2O,3:5κ
2O′;1:5 κ
2O,4:5κ
2O′;2:5κ
2O,3:5κ
2O′;2:5κ
2O,4:5κ
2O′;3:5κ
2O,4:5κ
2O′)tetramagnesium lead(II) tris(propanoato-κ
2O,O′)plumbate(II)), (II). The title structures are compositional isomers which crystallize in the same space group type. The structure of (I) comprises molecules with symmetry

4
‾

3
m

$\overline{4}3m$

. The structure (II) comprises the complex cation {Pb(C3H5O2)6[Mg(H2O)3]4}4+ with the symmetry

4
‾

3
m

$\overline{4}3m$

and four anions [tris(propanoato-κ
2O,O′)plumbate(II)]−, [Pb(C3H5O2)3]− , with 3m symmetry. The central cations Ba12+ and Pb12+ in (I) and in the cation {Pb(C3H5O2)6[Mg(H2O)3]4}4+ of the structure (II), respectively, have similar structural features which are comparable to the environment of the Ba2+ cation in BaCa2(C3H5O2)6 [Stadnicka, K. & Glazer, A. M. (1980). Acta Cryst. B36, 2977–2985]. The molecules in (I) and the ions in (II) are interconnected by Owater‒H⋯Opropanoate hydrogen bonds of a moderate strength. The ethyl chains are disordered which is common in propanoates. However, there are unprecedented features in the title structures: 1) The central atom Pb12+ is the first known example of a Pb2+ cation which is surrounded by six carboxylates in a bidentate bridging mode, i.e. by 12 oxygens. 2) The anion [tris(propanoato-κ
2O,O′)plumbate(II)]− has a constitution with unusually prominent stereochemical activity of the 6s
2 electron pair of the cation Pb2+ completing the coordination to the tetrahedral one. Thus, its formula can be expressed as [Pb[ψ−4t](C3H5O2)3]−. 3) In both title structures, there are propanoate molecules with disordered carboxylate oxygens.
Preparation and comparative evaluation of PVC/PbO and PVC/PbO/graphite based conductive nanocomposites
Authors: Raza Junaid , Hamid Abdul , Khan Muhammad , Hussain Fakhar , Zada Amir , Tiehu Li , Ali Amjad , Fazil Perveen , Wahab Zainul 
Published: August 2022

Abstract
Two series, A and B, of PVC based nanocomposite polymer membranes (nCPMs) were prepared using PbO only and PbO/graphite mixture as a filler by solution casting method. Seven samples with varying compositions (5–35%) of filler particles were prepared for each series and were compared by thickness measurements, porosity, water uptake, swelling degree, ionic conductivity, ion exchange capacity (IEC), membrane potential and transport number. The maximum values for these characteristics were observed as 0.402 mm, 0.77, 141.3%, 0.11, 0.0033 Scm−1, 8.6 milli-eq.g−1, 0.19 V and 0.01391 for series-A composites whereas that of 0.367 mm, 0.83, 63.4%, 0.019, 0.00981 Scm−1, 5.21 milli-eq.g−1, 0.13 V and 0.0108 for series-B nCPMs respectively. The SEM images of membranes showed greater voids produced in the series-B compared to series-A composites. The maximum Ionic conductivity, IEC, membrane potential and transport number were observed for membrane with 25% PbO/graphite, 20% PbO and 35% PbO particles respectively.
Evaluasi Settling Pond pada Area Run of Mine (ROM)
Authors: Parhusip Masjon , Ernawati Rika , Cahyadi Tedy Agung 
Published: August 2022

Kualitas air akibat terkontaminasi oleh batubara akan membentuk larutan yang bersifat asam , sehingga perlu dilakukan penanganan terlebih dahulu sebelum di alirkan ke sungai. Tujuan penelitian ini adalah mengevaluasi settling pond dengan menentukan curah hujan rencana menggunakan distribusi gumbell dan menghitung debit air limpasan dengan menggunakan metode rasional. Data curah hujan yang digunakan merupakan data 10 tahun (2010-2020). Dari hasil penelitian diketahui nilai curah hujan rencana dengan perhitungan distribusi gumbell untuk periode ulang 5 Tahun adalah 39,4 mm/jam, sehingga perhitungan dengan metode rasional diketahui Debit air limpasan adalah 13.110,98 m3/jam. Perhitungan dimensi geometri settling pond dapat menampun debit air limpasan 12.852 m3. Pada makalah ini, penulis merekomendasikan pembuatan saluran terbuka dengan membagi catchment area I dan II. Diharapkan debit air limpasan pada catchment area I yang tidak terkontaminasi oleh tumpukan batubara langsung mengalir ke sungai kecil. Dari rekomendasi tersebut memberikan nilai debit air limpasan pada catchment area II menjadi 11.001,39 m3/jam. Sehingga settling pond dapat menampung debir air larian yang terkontaminasi oleh batubara pada catchment area II.
Situation with cancer care in Russia. Kidney cancer (median survival, cumulative survival, and survival of patients depending on their disease stage). Population-based study at the federal district level. Part 2
Authors: Merabishvili V. M. , Nosov A. K. 
Published: August 2022

Background. In the first part of our study, we described the dynamics of kidney cancer (С64) incidence and mortality, as well as reliability of kidney cancer surveillance in Russia. This study analyzed the effectiveness of cancer control measures in Russia by assessing patient survival using the data form the newly developed Population-based cancer registry of the North-Western Federal District.Materials and methods. We used the data from the Population-based cancer registry of the North-Western Federal District of Russia that has more than 1,350,000 records, including 35,629 kidney cancer patients. Standard methods of the European Network of Cancer Registries (EUROCARE program) were used for data processing and analysis.Results. Our findings confirmed that kidney cancer is characterized by a low death rate. Over the last 18 years, median survival of kidney cancer patients in the North-Western Federal District of Russia increased form 4 years to 6.5 years. The 1-year survival rate increased from 68 % to 78.5 % (by 16.5 %); 5-year cumulative observed survival increased from 47.3 % to 54.1 %; 5-year cumulative relative survival increased from 56.8 % to 61.8 %. Female kidney cancer patients demonstrated higher 5-year cumulative survival rates than male patients (65.8 % vs 43.9 %).Conclusion. We observed a positive dynamic of the main analytical indicators of cancer control, including an increase in the median survival and 5-year cumulative survival of kidney cancer patients.
Protective effect of carwin capsules against cyclophosphamide induced chromosomal aberrations in mice
Authors: Thakur Niharika , Upmanyu Neeraj , Saxena Rajiv 
Published: August 2022

The concept of polyherbalism has been highlighted in , an Ayurvedic literature dating back to 1300 AD. Polyherbal formulations enhance the therapeutic action and reduce the concentrations of single herbs, thereby reducing adverse events. In the present study, the clastogenic effect of carwin capsuleshas been evaluated against cyclophosphamide (CP)-induced chromosomal aberrations in the bone marrow cells of the mice. Genotoxicity was carried out in mouse bone marrow cells. Animals were divided into four groups each containing four animals. Group I (control) was treated orally with vehicle (acacia suspension- 1ml/100gm), Group II was treated i.p. with cyclophosphamide (50 mg/kg, bw.), Group III was treated orally with carwin alone (1.5 mg/animal, bsa.), and Group IV was treated with cyclophosphamide + carwin. Animals were pretreated for 7 days with test drug (carwin). The evaluating parameter was to count total number of aberrated chromosomes and its various types. The results demonstrate that carwin was found to be significant (P&#60;0.01) as compared to cyclophosphamide treated as the no. of total aberrated chromosomes in carwin treated was decreased effectively. And also carwin was able to significantly (P&#60;0.01) protect the action caused by cyclophosphamide as well was also found to be effective antigenotoxic (P&#60;0.01) as compared to cyclophosphamide, when total no. of aberrated cells and their types were scored. Therefore, the results suggest a genotoxic potential of carwin capsules.
Bacteriological characteristics of hypervirulent Klebsiella pneumoniae rmpA gene (hvKp-rmpA)-harboring strains in the south of Iran
Authors: Shoja Saeed , Ansari Maryam , Bengar Saman , Rafiei Azam , Shamseddin Jebreil , Alizade Hesam 
Published: August 2022

Background and Objectives: To provide data on the occurrence of classical K. pneumoniae (cKp) and hypervirulent Klebsi- ella pneumoniae (hvKp) strains harboring the gene encoding regulator of mucoid phenotype A (rmpA) and evaluated charac- teristics of virulence biomarkers, carbapenemase, extended-spectrum-β-lactamase (ESBL)-producing, and capsule serotypes among K. pneumoniae clinical isolates collected in the south of Iran.
Materials and Methods: A total of 400 K. pneumoniae isolates were collected. First, the K. pneumoniae isolates were screened for rmpA gene by PCR, and then they were characterized for the presence of the virulence genes (pagO, iucA, iroB, luxR), capsular serotype genes (K1, K2, K5, K20, K54, and K57), carbapenemase (bla , bla IMP, bla , bla KPC , bla ,bla OXA-48 , and bla ) and ESBL (bla CTX-M SHV and blaTEM) genes. For all K. pneumoniae isolates phenotypic tests in- clude of string test and disk diffusion test were performed.
Results: In total, 16 (4%) hvKp-rmpA+ and 384 (96%) cKp were observed. Of hvKp-rmpA+ strains, 16 (100%) were carried pagO, iroB, and luxR genes, and 13 (81.3%) strains harbored iucA gene. The most prevalent capsular type genes were K1 (62%) and K2 (19%) in hvKp-rmpA+ strains. The incidence of bla SHV gene in hvKp and cKp was 94% (15/16) and 87.5% (336/384), respectively. The cKp isolates carried bla. NDM (30/384; 7.8%) gene.

Conclusion: Our data suggest that the incidence of hvKp was low. Also, hvKp-rmpA+ strains have less antibiotic resistance than cKp isolates. Serotypes K1 and K2, and bla SHV gene were strongly associated with hvKp-rmpA+.
Experiência museal no distrito de Mazagão Velho-AP: visitação em movimento
Authors: Videira Piedade Lino , Vasconcelos José Gerardo 
Published: August 2022

Neste artigo, deu-se enfoque ao território distrital de Mazagão Velho, localizado no município de Mazagão, estado do Amapá, como espaço museal afro-amapaense, ante a sua relevância histórica e cultural, como reduto de negras e negros que protegem do apagamento e esquecimento suas heranças culturais/religiosas, as quais resistem ao tempo e conformam a geografia social da comunidade. A metodologia utilizada pautou-se em estudo teórico-bibliográfico e com base em entrevistas semiestruturadas, endereçado a oito guardiões culturais, sendo quatro mulheres e quatro homens atuantes na comunidade. Concluiu-se que a cultura, a memória e a territorialidade, numa perspectiva educativa e patrimonial, sinalizam ser uma ação comunitária e recurso didático-pedagógico estratégico para salvaguardar patrimônio cultural na/da comunidade.
Experiencias docentes, casos relevantes en la práctica docente y formación de profesores
Authors: Cortez Sic José Enrique , Rivas Oscar Hugo López , Crispin Haydee Lucrecia 
Published: August 2022

Resumen: El trabajo trae reflexión sobre prácticas pedagógicas relevantes, asumidas como “casos de enseñanza”, y que fueron identificadas, valoradas y analizadas por un gran número de docentes en servicio en la red educativa. Estos docentes han sido seguidos y, a partir de la identificación de innovaciones en sus tareas en el aula, actúan como sujetos de sistematización de estas experiencias. Esto asegura un registro histórico al servicio de las nuevas generaciones de docentes que, al consultar estos documentos, encontrarán experiencias enriquecedoras para la mejora del sistema educativo. Antes de presentar estas relevantes experiencias, se presenta a modo de introducción un breve panorama de la formación inicial y continua de los docentes en Guatemala, en particular la implementación de una estrategia consensuada entre los profesores guatemaltecos y la Universidad Nacional de Guatemala a través de la Escuela de Educación. Formación de Docentes de Educación Primaria, quienes actuaron como mediadores ante el Ministerio de Educación, alcanzando acuerdos impensables que facilitaron la implementación de medidas para mejorar la formación docente y también acciones que constituyeron reformas básicas para la educación en el país. En educación se valoran los resultados a medio y largo plazo, y estas transformaciones se vienen implementando desde hace más de una década. En este análisis, la evidencia que surge de este proceso se destaca de la experiencia de los docentes cuya formación se desarrolló en el ámbito del Programa Académico de Desarrollo Profesional Docente.
Palabras claves: Formación docente. Prácticas relevantes en el aula. Casos de enseñanza. Escuelas normales. Reformas básicas.
Outcomes of a Quality Improvement Project: Screening for Adverse Childhood Experiences in Medication-Assisted Treatment
Authors: Pykare Justin D. , Knox Louise H. 
Published: August 2022

BackgroundAdverse childhood experiences (ACEs) are traumatic childhood events that alter biopsychological markers of the human body, causing significant damaging lifelong effects and increasing health risk behavior, including substance use disorder (SUD).ObjectiveThis project evaluated an ACE screening tool in medication-assisted treatment (MAT) patients at a federally qualified healthcare center (FQHC) via a handheld patient tablet.MethodsAll MAT patients received the 10-question Kaiser Permanente ACE screening tool; 192 patients (N) (98 men and 94 women) completed the ACE screening. Age and gender demographics were collected. Pre- and post-ACE screening behavioral health (BH) referral rates were measured utilizing electronic health record (EHR) reports. After 3 months, post-ACE screening BH referral rates were compared to pre-ACE screening rates from the same 3 months of the previous year.ResultsPost-ACE screening increased BH referrals by 29.76%, a statistically significant finding (z < .00001).ConclusionScreening for ACEs in MAT clinics is an effective trauma-informed intervention to increase BH referrals.Implications for NursingUsing technology to incorporate ACE screening in MAT is feasible and provides a deeper understanding of a patient’s mental health and trauma history.
Analisis Kontrastif Struktur Kalimat Arab Dan Indonesia Serta Implementasinya Dalam Pembelajaran
Authors: Umam Mustolikh Khabibul , Kuswahyuningrum Diah Ayu 
Published: August 2022

This study aims to compare the pattern of the Jumlah Ismiyyah and Fi'liyyah in Arabic with subject+predicate in Indonesian in terms of meaning and provisions and its implementation in several appropriate methods. This study uses a qualitative method with a library research approach. Data collection uses the documentation method. The data analysis technique uses contrastive analysis that compares the pattern of the number of Ismiyyah and Fi'liyyah in Arabic with subject+predicate in Indonesian in terms of meaning and provisions. The results show: Among the similarities and differences in the number of Ismiyyah and Fi'liyyah and 'subject+predicate' are: a) the pattern of the number of ismiyyah such as the sentence "Zaidun Ja'a" has the meaning always and remains in the sentence, while in Indonesian it only has meaning "Zaid is coming" only. b) The number of Ismiyyah has provisions between mubtada 'and khabar must be compatible in terms of mufrod, tasniyyah, and jama'. While the arrangement of the predicate subject in Indonesian does not require harmony in this regard and c) The number of fi'liyyah "Ja'a Zaidun" has a new meaning in the sentence, while in Indonesian it only means "Zaid comes". 2) the implementation of this contrastive analysis can be applied in learning the lecture and demonstration methods.

Abstrak
Penelitian ini bertujuan untuk membandingkan pola jumlah Ismiyyah dan Fi’liyyah dalam bahasa Arab dengan subjek+predikat dalam bahasa Indonesia dari segi makna dan ketentuan serta implementasinya pada beberapa metode yang sesuai. Penelitian ini menggunakan metode kualitatif dengan pendekatan library research. Pengumpulan data menggunakan metode dokumentasi. Teknik analisis data menggunakan analisis kontrastif yang membandingkan antara pola jumlah Ismiyyah dan Fi’liyyah dalam bahasa Arab dengan subjek+predikat dalam bahasa Indonesia dari segi makna dan ketentuan. Hasil penelitian menunjukkan: Di Antara persamaan dan perbedaan jumlah Ismiyyah dan Fi’liyyah dan ‘subjek+predikat” adalah: a) pola jumlah ismiyyah seperti kalimat “Zaidun Ja’a” memiliki makna selalu dan tetap dalam kalimatnya, sedangkan dalam BI hanya memiliki arti “Zaid datang” saja. b) Jumlah Ismiyyah memiliki ketentuan antara mubtada’ dan khabar harus serasi dalam segi mufrod, tasniyyah, dan jama’. Sedangkan susunan subjek predikat dalam BI tidak mengharuskan keserasian dalam hal tersebut dan c) Jumlah fi’liyyah “Ja’a Zaidun” memiliki makna baru dalam kalimatnya, sedangkan dalam BI hanya sekadar memiliki arti “Zaid datang” saja. 2) implementasi analisis kontrastif ini dapat diterapkan di pembelajaran pada metode ceramah dan demonstrasi
Risk factors and mortality of carbapenem-resistant Klebsiella pneumoniae bloodstream infection in a tertiary-care hospital in China: an eight-year retrospective study.
Authors: Yang Hang , Ma Hua , Huang Xiaoming , Cui Yanhui , Peng Wenzhong , Zhu Fei , Ma Shiyang , Rao Mingjun , Zhang Peipei , Su Longxiang , Pan Pinhua , Chen Jie 
Published: August 2022

Abstract
Background
The prevalence of carbapenem-resistant Klebsiella pneumonia bloodstream infection (CRKP-BSI) is increasing worldwide. CRKP-BSI is associated with high rates of morbidity and mortality due to limited antibiotic choices. Here, we aim to identify the prevalence and risk factors for infection and mortality of CRKP BSI.
Methods
This was a retrospective study of the past data from January 1st, 2012 to December 31st, 2019 of adult patients with KP-BSI in Xiangya Hospital, China.
Results
Among the 706 incidences included in this study, 27.4% of them (212 / 753) being CR-KP strains. The occurrence of CRKP-BSI was increased from 20.69 to 37.40% from 2012 to 2019. Hematologic malignancies and ICU acquired infection were identified to be substantial risk factors of carbapenem resistance. The overall 28-day mortality rates of CRKP-BSI patients was significantly higher than that of CSKP-BSI (P < 0.001). Logistic regression analysis identified severe sepsis or septic shock incidents, inadequate empirical antimicrobial therapy and corticosteroids use preceding infection onset as the independent predictors of 28-day mortality of CRKP-BSI patients. However, high dose carbapenem combination therapy was identified as anticipated factors of low 28-day mortality.
Conclusion
The occurrence of CRKP-BSI was significantly increased during the study period. Hematologic malignancies and ICU acquired infection were associated with the development of CRKP BSI. Severe sepsis or septic shock incidents, inadequate empirical antimicrobial therapy and corticosteroids use preceding infection onset caused significant increase of mortality rates in CRKP-BSI patients. High dose carbapenem combination therapy was associated with better outcome.
Tissue Characteristics of Residual Lesion in Patients With Acute Coronary Syndrome Caused by Plaque Rupture Versus Plaque Erosion: A Single-center, Retrospective, Observational Study
Authors: Suzuki Wataru , Ohashi Hirofumi , Ando Hirohiko , Nakano Yusuke , Takashima Hiroaki , Fujimoto Masanobu , Sawada Hiroaki , Goto Reiji , Suzuki Akihiro , Sakurai Shinichiro , Amano Tetsuya 
Published: August 2022

Abstract
PurposePatients with acute coronary syndrome (ACS), frequently caused by plaque rupture (PR), often have vulnerable plaques in residual and culprit lesions. However, whether this occurs in patients with plaque erosion (PE) as well is unknown. Therefore, we compared the tissue characteristics of residual lesions in patients with PE and those with PR.MethodsThe data of 88 patients with ACS who underwent both optimal coherence tomography (OCT) and intravascular ultrasound (IVUS) were retrospectively analyzed. Based on plaque morphology of the culprit lesions identified using OCT, patients were classified into PE and PR groups. The tissue characteristics of residual lesions evaluated using integrated backscatter IVUS were compared between the two groups after percutaneous coronary intervention. ResultsPatients were classified into the PE group (n=23) and PR group (n=35). The PE group had a significantly lower percent lipid volume and a higher percent fibrous volume than those of the PR group (35.0±17.8% vs. 49.2±13.4%, p<0.001; 63.2±17.1% vs. 50.3±13.1%, p=0.002, respectively). Receiver operating characteristic curve analysis revealed that the percent lipid volume in the residual lesions was a significant discriminant factor in estimating the plaque morphology of the culprit lesion (optimal cut-off value, <43.5%; sensitivity and specificity values were 73.9% and 68.6%, respectively).ConclusionsPatients with PE had a significantly lower percent lipid volume and a significantly higher percent fibrous volume in the residual lesions than in those with PR, suggesting that the nature of coronary plaques in patients with PE is different from that in patients with PR.