bluuebunny/crossref_metadata_2025_split huggingface dataset:
EDQWS: an enhanced divide and conquer algorithm for workflow scheduling in cloud
Authors: Khojasteh Toussi Ghazaleh , Naghibzadeh Mahmoud , Abrishami Saeid , Taheri Hoda , Abrishami Hamid 
Published: May 2022

AbstractA workflow is an effective way for modeling complex applications and serves as a means for scientists and researchers to better understand the details of applications. Cloud computing enables the running of workflow applications on many types of computational resources which become available on-demand. As one of the most important aspects of cloud computing, workflow scheduling needs to be performed efficiently to optimize resources. Due to the existence of various resource types at different prices, workflow scheduling has evolved into an even more challenging problem on cloud computing. The present paper proposes a workflow scheduling algorithm in the cloud to minimize the execution cost of the deadline-constrained workflow. The proposed method, EDQWS, extends the current authors’ previous study (DQWS) and is a two-step scheduler based on divide and conquer. In the first step, the workflow is divided into sub-workflows by defining, scheduling, and removing a critical path from the workflow, similar to DQWS. The process continues until only chain-structured sub-workflows, called linear graphs, remain. In the second step which is linear graph scheduling, a new merging algorithm is proposed that combines the resulting linear graphs so as to reduce the number of used instances and minimize the overall execution cost. In addition, the current work introduces a scoring function to select the most efficient instances for scheduling the linear graphs. Experiments show that EDQWS outperforms its competitors, both in terms of minimizing the monetary costs of executing scheduled workflows and meeting user-defined deadlines. Furthermore, in more than 50% of the examined workflow samples, EDQWS succeeds in reducing the number of resource instances compared to the previously introduced DQWS method.
Prevalence and determinants of women’s satisfaction on the quality of safe abortion service in Northwest Ethiopia
Authors: Gashaye Kiros Terefe , Taddese Asefa Adimasu , Birhan Tilahun Yemanu 
Published: May 2022

Abstract
Background
The standard of treatment in developing countries is harmed by a complex political landscape, an uncertain economic climate, rapid population growth, and clients are constantly complaining about the poor health system. Patients’ assessments of the benefits and shortcomings of the service provided to them are expressed as satisfied or dissatisfied. The objective of this study was to determine the magnitude of women’s satisfaction on quality of safe abortion and factors associated with it in Northwest Ethiopia.

Methods
Institution-based cross-sectional study design was done to collect data from 618 women in the selected health facilities in Northwest Ethiopia. Women having the gestational trophoblastic disease (partial mole) and those who cannot hear or are seriously ill during the data collection period were excluded. The study subjects were chosen using a randomization process, and each participant was questioned after receiving all necessary abortion treatment and giving verbal consent. Both bivariable and multivariable logistic regression analysis was carried out to determine covariates significantly associated with women’s satisfaction on quality of abortion.

Results
The highest proportion of women who were reasoned out to terminate the fetus in the current pregnancy was due to financial problems (29.36%) and partner coercion (23.85%). Client satisfaction with safe abortion services in the study region was 25.10% (95% CI; 21.81–28.70). Women were 53.2% satisfied with the art of treatment/interpersonal abilities, 59.2% satisfied with the professional quality of care professionals, 54.5% satisfied with the physical environment, and 49.8% satisfied with the structure of the health care system, respectively. In the multivariable logistic regression analysis, women’s living solely 0.47(0.26–0.87) & living with 2 to 4 people 0.11(0.04–0.29), college and above level of education 1.78(1.01–3.15), wanted the status of pregnancy 0.44(0.23–0.85) and post-abortion contraceptive users 1.70(1.01–2.89) were factors significantly associated with women’s satisfaction level.

Conclusion
In this study, one-fourth of the women were satisfied with the quality of safe abortion services. Family size, women’s educational status, maternity status, and post-abortion contraception use were predictors of women’s satisfaction with the quality of abortion. Ethiopia’s government should concentrate on addressing contraception needs in order to prevent women from having multiple abortions.
Leveraging 5G network for digital innovation in small and medium enterprises: a conceptual review
Authors: Olokundun Maxwell , Ogbari Mercy Ejovwokeoghene , Falola Hezekiah , Ibidunni Ayodotun Stephen 
Published: May 2022

AbstractSmall- and medium-sized enterprises (SMEs) play a crucial role within a country’s economy considering that they provide a source of skills and innovation for entrepreneurship and their capacity for introducing, integrating and disseminating new technologies is incomparable. However, the world may be looking at an impending devastating recession delivered by the coronavirus pandemic. As governments intensify restrictions on business to halt the spread of the pandemic, the fear of the virus also reconfigures the very concept of business and the workplace. Therefore, there is a need for a greater focus on digital transformation considering that physical distancing requirements to curb the spread of this virus may become a cultural orientation for businesses and the workplace. A real digital transition is anticipated for small businesses with the 5G network technology. 5G network will not just be a technological connection but will affect different socio-economic sectors and will stimulate innovation in small companies. The goal of this paper was to carry out a literature review on the potential ways small businesses can leverage on 5G network for digital innovation. The paper proposed that small and medium businesses can leverage the 5G Mobile Technology through enhanced interpersonal communication, expanded remote work opportunities, innovative digital tools and supply chain efficiency. Finally, while many individuals and small business owners will profit from 5G technology some will work to undermine it. As a result, companies must keep this in mind when implementing 5G, or other new technology, and adjust their security protocols accordingly to remain secure.
Human pediculosis, a global public health problem
Authors: Fu Yi-Tian , Yao Chaoqun , Deng Yuan-Ping , Elsheikha Hany M. , Shao Renfu , Zhu Xing-Quan , Liu Guo-Hua 
Published: May 2022

Abstract
Background
Human pediculosis is caused by hematophagous lice, which are transmitted between individuals via direct and/or indirect contact. Despite the public health importance of louse infestation, information concerning the global burden of pediculosis and the epidemiological landscape of louse-borne diseases is limited. The aim of this review was to summarize the biology, epidemiology, diagnosis, and control of lice infestation in humans. We also discussed the latest advances in molecular taxonomy and molecular genetics of lice.

Methods
We searched five electronic bibliographic databases (PubMed, ScienceDirect, CNKI, VIP Chinese Journal Database, and Wanfang Data) and followed a standard approach for conducting scoping reviews to identify studies on various aspects of human lice. Relevant information reported in the identified studies were collated, categorized, and summarized.

Results
A total of 282 studies were eligible for the final review. Human pediculosis remains a public health issue affecting millions of people worldwide. Emerging evidence suggests that head lice and body lice should be considered conspecific, with different genotypes and ecotypes. Phylogenetic analysis based on mitochondrial (mt) cytb gene sequences identified six distinct clades of lice worldwide. In addition to the direct effect on human health, lice can serve as vectors of disease-causing pathogens. The use of insecticides plays a crucial role in the treatment and prevention of louse infestation. Genome sequencing has advanced our knowledge of the genetic structure and evolutionary biology of human lice.

Conclusions
Human pediculosis is a public health problem affecting millions of people worldwide, particularly in developing countries. More progress can be made if emphasis is placed on the use of emerging omics technologies to elucidate the mechanisms that underpin the physiological, ecological, and evolutionary aspects of lice.

Graphic Abstract
Multi-expert multi-criteria decision analysis model to support the conservation of paramount elements in industrial facilities
Authors: Jato-Espino Daniel , Martín-Rodríguez Ángel , Martínez-Corral Aurora , Sañudo-Fontaneda Luis A. 
Published: May 2022

Abstract
The coupling of urban retrofitting with climate change adaptation and environmental conservation is impacting on current industrial activities such as electricity production based on fossil fuels. Therefore, new tools are required to support adaptive reuse towards the conservation of industrial facilities, in order to leave testament of their cultural and industrial heritage once their production activities cease to exist. Multi-Criteria Decision Analysis (MCDA) can help analyse complex interactions between industrial elements, society, culture and nature, providing key benefits when approaching heritage investigations. In this context, this research concerned the design of a Multi-Expert MCDA (ME-MCDA) methodology to support the selection of paramount heritage elements in power plants based on the collection and processing of the views of a panel of experts to result in consensus groups. This approach was tested using a case study in the As Pontes power plant (NW Spain), which will be dismantled in a near future. The results achieved pointed out to cooling towers, boilers, chimney and turbine hall as the fundamental elements to preserve due to their relevance across a set of technical, historical and sociocultural criteria. These outcomes proved the usefulness of the proposed approach in favouring the valorisation of industrial facilities as heritage areas protecting the social and cultural history of a territory.
XYtracker: a new approach to estimate fault rupture extent in real time for large earthquakes
Authors: Xiao Ying , Yamada Masumi 
Published: May 2022

AbstractWe present a methodology for estimating fault geometry and utilizing the distance to the fault for the shaking estimation to improve the accuracy of real-time shaking estimates for large earthquakes. Most of the earthquake early warning system currently estimates the seismic intensity with the ground-motion prediction equations (GMPE) as a function of the hypocenter distance. However, using the fault distance computed from a finite source model can improve the accuracy of the shaking intensity estimation for large earthquakes. This study proposes a novel methodology, XYtracker, to estimate the surface projection of the fault extent and real-time seismic intensity. For large earthquakes, high-frequency ground motions tend to saturate over the magnitude range and strongly correlate with fault distance. As a result, this work can achieve the fault extent using seismic intensity and GMPE. We considered three types of fault models: point-source, line-source, and rectangle-source model. We found the most probable model parameters for each model by minimizing the residual sum of squares between the observed and estimated seismic intensities. The Akaike Information Criterion selected the most probable model among them. The strong motion data set of the 2008 Wenchuan, 2011 Tohoku, and 2016 Kumamoto earthquakes was used to test our methodology. The new method for estimating the fault geometry can obtain the ongoing rupture length and direction using the strong motion data. The model selection scheme with the Akaike Information Criterion selected the finite-source model to explain the shaking distribution. Results revealed that this new approach performed well in estimating the fault dimension. The method can promote the accuracy of the seismic intensity estimation for future large earthquakes, including the subduction earthquakes.
Graphical Abstract
Microbial synthesis of long-chain α-alkenes from methanol by engineering Pichia pastoris
Authors: Cai Peng , Li Yunxia , Zhai Xiaoxin , Yao Lun , Ma Xiaojun , Jia Lingyun , Zhou Yongjin J. 
Published: May 2022

Abstractα-Alkenes (terminal alkenes) are important fuel and platform chemicals that are mainly produced from petroleum. Microbial synthesis might provide a sustainable approach for α-alkenes. In this work, we engineered the methylotrophic yeast Pichia pastoris to produce long-chain (C15:1, C17:1 and C17:2) α-alkenes via a decarboxylation of fatty acids. Combinatorial engineering, including enzyme selection, expression optimization and peroxisomal compartmentalization, enabled the production of 1.6 mg/L α-alkenes from sole methanol. This study represents the first case of α-alkene biosynthesis from methanol and also provides a reference for the construction of methanol microbial cell factories of other high-value chemicals.
Graphical Abstract
Assessment of biosecurity status in dairy cow farms
Authors: Harun Mohammedsham Husen , Shimelis Shihun , Andargie Bamlaku , Abdi Michael Yousuf , Bekere Hassen Yusuf 
Published: May 2022

Abstract
Background
Biosecurity plays an irreplaceable role in preventing diseases, increasing productivity of dairy herd and welfare on the farm, prevention of drug resistance and public health safety. Assessment of biosecurity measures were carried out both by observations and questionnaires from December 2019 to April 2020 in dairy cows’ farms. In addition to assessment of biosecurity, the present study also intended to identify factor associated to biosecurity and its specific component implementation.

Results
Out of 125 biosecurity practices considered to evaluate the overall biosecurity status of dairy farms, the scores ranged from 34 to 75. The overall percentage of the biosecurity score varied from 27.2 to 60%. Out of 20 dairy farms included in the present study, nine farms gained a percentage score of greater than or equal to 50% (ranging from 50.4 to 60%), thus their biosecurity status was evaluated as “Good”. The remaining 11 farms attained a percentage score lower than 50% (varying from 27.2 to 46.4%) and therefore graded as “Poor”. In this study biosecurity categorized in to four components: traffic control (21.5 ± 4.3), isolation (14.45 ± 2.2), sanitation (16.65 ± 6.83) and health management (3.25 ± 1.07) with their respective mean ± standard deviation of each component. Out of four biosecurity components: isolation and traffic control were implemented better, but sanitation and animal health management were poorly implemented. Fisher’s exact test analysis of the obtained results showed that among all factors assumed to affect biosecurity adoption, however only a significant association (P < 0.05) between biosecurity status and location of farms was appreciated.

Conclusions
In conclusion, the overall adoption of biosecurity measures in the dairy farms was evaluated to be poor. Thus, raising awareness of herd owners, facilitating dairy husbandry training by the concerned body, pushing herd owners to develop a biosecurity plan and practicing it. And, especially improvement of sanitation and animal health management systems should be prioritized by policy makers or the concerned organizations.
The development and quality of jackfruit-based ethnic food, gudeg, from Indonesia
Authors: Yudhistira Bara 
Published: May 2022

AbstractGudeg is one of the Indonesian foods that are identic with the city of Yogyakarta. It has a long history and development, which is closely related to the history of Yogyakarta and Surakarta. However, it is currently known as a Yogyakarta specialty. Based on raw materials and packaging, it is divided into many kinds during the development process. The type of raw material used in producing gudeg is divided into two, jackfruit and manggar, while based on the processing method, it consists of wet and dry. Presently, it is marketed in various packages, including kendil, besek, boxed and canned gudeg. Research on the nutritional content and functional properties of gudeg has been carried out, although it is still limited to the macronutrient content, while for the functional properties only the fiber content. This research has mostly been done on gudeg jackfruit than on manggar gudeg. Therefore, this study focuses on the history, processing, packaging, nutritional value and sensory properties of gudeg. This shows that product information is an important factor related to consumers’ perception of gudeg due to the fact they normally consider the sensory aspects, tradition, convenience and ease of cooking in selecting traditional foods.
Longitudinal Molecular Profiling of Circulating Tumor Cells in Metastatic Renal Cell Carcinoma
Authors: Bootsma Matthew , McKay Rana R. , Emamekhoo Hamid , Bade Rory M. , Schehr Jennifer L. , Mannino Matthew C. , Singh Anupama , Wolfe Serena K. , Schultz Zachery D. , Sperger Jamie , Xie Wanling , Signoretti Sabina , Kyriakopoulos Christos E. , Kosoff David , Abel Edwin J. , Helzer Kyle T. , Rydzewski Nicholas , Bakhtiar Hamza , Shi Yue , Blitzer Grace , Bassetti Michael , Floberg John , Yu Menggang , Sethakorn Nan , Sharifi Marina , Harari Paul M. , Choueiri Toni K. , Lang Joshua M. , Zhao Shuang G. 
Published: May 2022

PURPOSE Liquid biopsies in metastatic renal cell carcinoma (mRCC) provide a unique approach to understand the molecular basis of treatment response and resistance. This is particularly important in the context of immunotherapies, which target key immune-tumor interactions. Unlike metastatic tissue biopsies, serial real-time profiling of mRCC is feasible with our noninvasive circulating tumor cell (CTC) approach. METHODS We collected 457 longitudinal liquid biopsies from 104 patients with mRCC enrolled in one of two studies, either a prospective cohort or a phase II multicenter adaptive immunotherapy trial. Using a novel CTC capture and automated microscopy platform, we profiled CTC enumeration and expression of HLA I and programmed cell death-ligand 1 (PD-L1). Given their diametric immunological roles, we focused on the HLA I to PD-L1 ratio (HP ratio). RESULTS Patients with radiographic responses showed significantly lower CTC abundances throughout treatment. Furthermore, patients whose CTC enumeration trajectory was in the highest quartile (> 0.12 CTCs/mL annually) had shorter overall survival (median 17.0 months v 21.1 months, P < .001). Throughout treatment, the HP ratio decreased in patients receiving immunotherapy but not in patients receiving tyrosine kinase inhibitors. Patients with an HP ratio trajectory in the highest quartile (≥ 0.0012 annually) displayed significantly shorter overall survival (median 18.4 months v 21.2 months, P = .003). CONCLUSION In the first large longitudinal CTC study in mRCC to date to our knowledge, we identified the prognostic importance of CTC enumeration and the change over time of both CTC enumeration and the HP ratio. These insights into changes in both tumor burden and the molecular profile of tumor cells in response to different treatments provide potential biomarkers to predict and monitor response to immunotherapy in mRCC.
Somatic RET Indels in Sporadic Medullary Thyroid Cancer: Prevalence and Response to Selpercatinib
Authors: Elisei Rossella , Ciampi Raffaele , Matrone Antonio , Prete Alessandro , Gambale Carla , Ramone Teresa , Simeakis George , Materazzi Gabriele , Torregrossa Liborio , Ugolini Clara , Romei Cristina 
Published: May 2022

Abstract

Context
Although the majority of RET alterations are single nucleotide variants (SNV), small deletions and/or insertions have been reported at variable prevalence. No information about the efficacy of RET-specific inhibitors in patients harboring RET indels has been provided.

Objective
We present an update on the prevalence of RET indels in medullary thyroid cancer (MTC) and describe the efficacy of selpercatinib in patients with advanced MTC with RET indels.

Methods
The MTC tissues of 287 patients were analyzed using an Ion S5 targeted sequencing. The functional role of the reported indels have been evaluated by MutationTaster. Clinical and pathological data of MTC patients harboring a RET indel were collected and analyzed. Two patients with a RET indel were treated with selpercatinib.

Results
Among 178 RET-positive cases, 147 (82.6%) harbored a SNV and 31 (17.4%) a RET in-frame indel. Nine indels were not previously reported and were found to be disease causing by MutationTaster. Patients harboring an indel were found to have an aggressive disease and 2 of them were treated with selpercatinib, experiencing a good response to the treatment.

Conclusion
These data show that RET indels are not infrequent and correlate with an aggressive disease. Two RET indel–positive patients showed a partial response to the treatment with a highly selective RET inhibitor; thus, these RET indels can be considered actionable mutations. In order to not miss these alterations, the analysis of the full gene is recommended.
Lifespan and ROS levels in different Drosophila melanogaster strains after 24 h hypoxia exposure
Authors: Malacrida Sandro , De Lazzari Federica , Mrakic-Sposta Simona , Vezzoli Alessandra , Zordan Mauro A. , Bisaglia Marco , Menti Giulio Maria , Meda Nicola , Frighetto Giovanni , Bosco Gerardo , Dal Cappello Tomas , Strapazzon Giacomo , Reggiani Carlo , Gussoni Maristella , Megighian Aram 
Published: May 2022

ABSTRACT
During recent decades, model organisms such as Drosophila melanogaster have made it possible to study the effects of different environmental oxygen conditions on lifespan and oxidative stress. However, many studies have often yielded controversial results usually assigned to variations in Drosophila genetic background and differences in study design. In this study, we compared longevity and ROS levels in young, unmated males of three laboratory wild-type lines (Canton-S, Oregon-R and Berlin-K) and one mutant line (Sod1n1) as a positive control of redox imbalance, under both normoxic and hypoxic (2% oxygen for 24 h) conditions. Lifespan was used to detect the effects of hypoxic treatment and differences were analysed by means of Kaplan–Meier survival curves and log-rank tests. Electron paramagnetic resonance spectroscopy was used to measure ROS levels and analysis of variance was used to estimate the effects of hypoxic treatment and to assess ROS differences between strains. We observed that the genetic background is a relevant factor involved in D. melanogaster longevity and ROS levels. Indeed, as expected, in normoxia Sod1n1 are the shortest-lived, while the wild-type strains, despite a longer lifespan, show some differences, with the Canton-S line displaying the lowest mortality rate. After hypoxic stress these variances are amplified, with Berlin-K flies showing the highest mortality rate and most evident reduction of lifespan. Moreover, our analysis highlighted differential effects of hypoxia on redox balance/unbalance. Canton-S flies had the lowest increase of ROS level compared to all the other strains, confirming it to be the less sensitive to hypoxic stress. Sod1n1 flies displayed the highest ROS levels in normoxia and after hypoxia. These results should be used to further standardize future Drosophila research models designed to investigate genes and pathways that may be involved in lifespan and/or ROS, as well as comparative studies on specific mutant strains.