bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development of a method for processing log files using clustering
Authors: Mahmudova Shafagat 
Published: June 2022

Abstract
A log file is a document that keeps track of all events that occur on a website
or server. Many log files are very large, so they can be regularly written over
outdated content, or entire collections of log files with names, including a date,
for example, can be created. In the event of technical problems, site inaccessibility,
virus infection, hacker attacks and Distributed Denial of Service (DDoS) attacks,
the resource administrator can use the information in log to find the cause,
which makes it easier and faster to eliminate unwanted incidents. The paper
analyzes the definition, types, location, use and examples of log files.
Data is transferred to the MySQL database using the Squid.db database.
Clustering is performed using a database. The study highlights clustering,
analyzes metrics, and determines the proximity of clusters and objects in
clusters in Euclidean space. Experiments are conducted and the results are
satisfactory. For example, data is transferred to the MySQL database using
the Squid.db database. Since the Squid proxy server is a cache proxy server,
it stores resources, and the work is done quickly on the next request. Data
are clustered using a compiled table of databases transferred to MySQL
via Squid proxy. In this case, unnecessary entries are deleted from the table,
which significantly speeds up data processing. The application of clustering
method in problem solving is fast and simple. For the problem stated, the
degree of closeness of clusters and objects in clusters in Euclidean space is
determined. Experiments are conducted using obtained results.
Early changes in gene expression profiles in AML patients during induction chemotherapy
Authors: Jakobsen Ingrid , Sundkvist Max , Björn Niclas , Gréen Henrik , Lotfi Kourosh 
Published: June 2022

Abstract
Background: Elucidation of the genetic mechanisms underlying treatment response to standard induction chemotherapy in AML patients is warranted, in order to aid in risk-adapted treatment decisions as novel treatments are emerging. In this pilot study, we explored the treatment-induced expression patterns in a small cohort of AML patients by analyzing differential gene expression (DGE) over the first two days of induction chemotherapy.Methods: Blood samples were collected from ten AML patients at baseline (before treatment initiation) and during the first two days of treatment (Day 1; approximately 24 h, and Day 2; approximately 48 h after treatment initiation, respectively) and RNA was extracted for subsequent RNA sequencing. DGE between time points were assessed by pairwise analysis using the R package edgeR version 3.18.1 in all patients as well as in relation to treatment response (complete remission, CR, vs non-complete remission, nCR). Ingenuity Pathway Analysis (Qiagen) software was used for pathway analysis and visualization.Results: After initial data quality control, two patients were excluded from further analysis, resulting in a final cohort of eight patients with data from all three timepoints. DGE analysis demonstrated activation of pathways with genes directly or indirectly associated with NF-κB signaling. Significant activation of the NF-κB pathway was seen in 50% of the patients two days after treatment start, while iNOS pathway effects could be identified already after one day. nCR patients displayed activation of pathways associated with cell cycle progression, oncogenesis and anti-apoptotic behavior, including the STAT3 pathway and Salvage pathways of pyrimidine ribonucleotides. Notably, a significant induction of cytidine deaminase, an enzyme responsible for the deamination of Ara-C, could be observed between baseline and Day 2 in the nCR patients but not in patients achieving CR.Conclusions: In conclusion, we show that time-course analysis of gene expression represents a feasible approach to identify relevant pathways affected by standard induction chemotherapy in AML patients. This poses as a potential method for elucidating new drug targets and biomarkers for categorizing disease aggressiveness and evaluating treatment response. However, more studies on larger cohorts are warranted to elucidate the transcriptional basis for drug response.
A Hybrid Fuzzy Model To The Ranking Problem of Companies operating R&amp;D Activities in Technology Innovation Centers
Authors: Ates Kubra Tumay , Sahin Cenk 
Published: June 2022

Abstract
Technology innovation centers where universities share information with industry collaborations and institutions and have a wide range of companies in its field. Developing technology and competition have forced to make innovations, the companies in technology innovation centers operating Research and Development (R&D) activities have tried to prove themselves by proposing different projects to industrial organizations and making innovations and they are still working since they may get some promotions from the government. A decision for ranking companies has a number of criteria, which range from financial incentives and infrastructure to R&D activities. Most of the criteria are based on linguistic terms that decision makers can express with fuzzy statements. For this reason, in this study, the problem for ranking the companies operating R&D activities is solved by using a hybrid model, combining the Fuzzy Analytic Hierarchy Process and Fuzzy TOPSIS methods. Four different main decision criteria, 16 sub-criteria and three random companies were considered for this study. A network was formed, and surveys were carried out with the opinions of the experts on R&D activities and including experts from some technology development zones of Turkey. The proposed hybrid model was applied successfully to a case study for the ranking the companies operating R&D activities in Çukurova University Technology Development Zone in Turkey. Using actual data, it is showed the applicability of the proposed approach and compare the best alternative obtained by the proposed method for three companies in Çukurova University Technology Development Zone in Turkey.
Threshold analysis method for aircraft avoiding convective weather
Authors: Xiao Shumin , Li Yinfeng , Shang Ranran , Yang Lu , Wei Xiujie 
Published: June 2022

Convective weather is an important weather phenomenon that affects aircraft operation, and the determination and analysis of convective weather characteristic thresholds is the basis and premise for airspace availability analysis and aircraft diversion. This paper innovatively proposes a threshold analysis method for aircraft to avoid convective weather. Firstly, the historical meteorological data and the track data are adopted in spatiotemporal and synchronous fusion. Secondly, the K-means clustering algorithm is used to determine the characteristic threshold range of the aircraft to avoid convective weather. Then, combined with the random forest classification algorithm, each threshold is again classified 0-1 through machine learning to determine the best avoidance threshold for weather features. Finally, the new construction index evaluation is used to evaluate the reliability of the algorithm. According to the threshold analysis method, the radar reflectivity factor is taken as the research object to carry out an example analysis. The example shows that when the radar reflectivity value is 34 dBZ, the accuracy rate is 96.58 %, the false alarm rate is 2.45 %, and the missing alarm rate is 0.97 %, all of which are better than the decision tree method, thus verifying the reliability and practicability of the algorithm.
Assessing the nonlinear static stiffness of rail pad using finite element method
Authors: Othman Muhammad Iqbal Haikal , Abdul Wahab Abdul Malek , Hadi Muhamad Sukri , Mohamad Noor Noraishah 
Published: June 2022

The unintended vibrations and sound emerging from train operation have an enormous impact on the surroundings, including the deterioration of the way, buildings, and structures. One proposed strategy to mitigate this issue is the installation of a rail pad inserted between the steel rail and concrete sleeper to provide flexibility to the track and cushion the shocks and vibrations generated by the train wheels’ movement. These materials have nonlinear, dissipative properties influenced by service conditions like temperature and toe load. This work aimed to investigate the static stiffness of different materials of the rail pad under the influence of temperature and toe load. The rail pads were categorized as soft, medium, or hard based on static stiffness. A 3D model of the rail pad, steel rail, and concrete sleeper was simulated and analyzed using ANSYS FEM software. The neo-Hookean model was used to model the rail pad, and the isotropic elasticity model was used for the steel rail and concrete sleeper. The static stiffness of the ethylene propylene diene monomer (EPDM) pad was 85.42 kN/mm, lower than that of thermoplastic elastomers (TPEs, 138.98 kN/mm) and ethylene vinyl acetate (EVA, 303.70 kN/mm) under reference conditions (20 °C), without including toe load effects. Increasing the temperature decreased the rail pad’s static stiffness, with the highest reduction of 53.49 %. However, increasing the toe load contributed up to a 23.53 % increase in the static stiffness of the rail pad.
Modification of slow sand filtration of secondary effluents by electric fields: electrokinetics and influence factors
Authors: Haaken Daniela , Schmalz Viktor , Dittmar Thomas , Worch Eckhard , Stolte Stefan 
Published: June 2022

Abstract
In this study, the effect of electric fields applied to a quartz sand bed on electrokinetics and the disinfection performance of an E-slow sand filter (reduction of Escherichia coli) were investigated. Results of electrokinetic experiments have shown that coliforms are electroosmotically transported to the cathode with a velocity of 0.6 cm h−1 (E = 4 V cm−1). In the absence of an electric field and at electric field strengths of &lt;4 V cm−1, a diffuse random movement to the cathode and the anode was the only translocation mechanism. Hence, the electroosmotic transport may represent an additional component of motion during E-slow sand filtration influencing its disinfection performance. Based on this, comparative experimental investigations on the disinfection performance of a slow sand filter without and combined with an electric field were carried out. In the absence of an electric field, the adsorptive filter effect of quartz sand contributes to an initial bacterial retention by 0.8 log levels. Applying an electric field strength of 4 V cm−1 caused an increase of E. coli reduction up to 4 log levels. The electrokinetically enhanced accumulation of E. coli in the filter bed is assumed to be the major effect mechanism in the E-slow sand filter.
MIR4435-2HG: A Tumor-associated Long Non-coding RNA
Authors: Zhao Fangnan , Liu Yuling , Tan Fangshun , Tang Lu , Du Zhuoying , Mou Jie , Zhou Gang , Yuan Chengfu 
Published: June 2022

Background:
It is well known that the changes in the expression level of LncRNA can affect the
progression of tumors, which has caused a great upsurge of research in recent years. Several LncRNAs have
been identified to affect a series of cancers and can promote tumor growth, migration, and invasion. In this
review, we aim to clarify the pathophysiological functions of LncRNA MIR4435-2 HG in multiple tumors.

Methods:
By searching the literature through PubMed, this paper summarizes the relationship between
MIR4435-2HG and tumor and its role in the occurrence and development of cancer and also explains the specific
molecular mechanism of the effect of MIR4435-2HG on cancer.

Results:
MIR4435-2HG can function as an oncogene in a variety of cancers. The expression level was reported
to be abnormally elevated in a series of cancers, consisting of melanoma, gastric cancer, head and neck squamous
cell carcinoma, oral squamous cell carcinoma, lung cancer, cervical cancer, prostate carcinoma, ovarian
cancer, breast cancer, hepatocellular carcinoma, clear cell renal cell carcinoma malignant, glioma, and colorectal
cancer. Moreover, MIR4435-2HG is related to the poor prognosis of a variety of cancers. MIR4435-2HG
can also affect tumor proliferation, invasion, and apoptosis. In addition, MIR4435-2HG can also enhance the
metabolic function of myeloid dendritic cells of elite HIV-1 controllers.

Conclusion:
MIR4435-2HG affects the development of a variety of cancers. It can act as a clinical marker for
early tumor diagnosis and affects tumor-targeted therapy.
Phyllanthus emblica L. Regulates BDNF/PI3K Pathway to Modulate Glutathione
for Mitoprotection and Neuroprotection in a Rodent Model of Ischemic
Stroke
Authors: Bhattacharya Pallab , Sarmah Deepaneeta , Verma Geetesh , Datta Aishika , Vadak Namrata , Chaudhary Antra , Kalia Kiran 
Published: June 2022

Introduction:
Ischemic stroke remains the leading cause of death worldwide and is the
primary cause of disability globally. Numerous studies have shown that plant-origin medicines are
promising and can influence the treatment of neurological disorders. Phyllanthus embilica L. (P.
emblica or Amla) is one of the herbal plants whose medicinal properties are widely studied. The
objective of the present study is to determine the neuroprotective effects of an aqueous extract of
the fruit of P. emblica (hereinafter referred to as just P. emblica) on cerebral ischemia-reperfusion
injury and explore if it can regulate BDNF/PI3K pathway to modulate glutathione for mitoprotection
and neuroprotection.

Methods:
In vivo studies were conducted on male Sprague Dawley rats, where rats were prophylactically
administered 100 mg/kg P. emblica for 30 days. In the treatment group, rats were given
100 mg/kg P. emblica, 1 h post middle cerebral artery occlusion (MCAo). Rats were evaluated for
neuro deficit and motor function tests. Brains were further harvested for infarct size evaluation,
biochemical analysis, protein expression studies, and mitochondrial studies.

Results:
Prophylaxis and treatment with P. emblica demonstrated significant improvement in
functional outcome with a reduction in infarct size. Normalization of glutathione, nitrite, and
malondialdehyde levels was also observed. Improvement in mitochondrial complex I and IV activities
was also reported. Expressions of BDNF, PI3K, SDF1 and VEGF increased while that of
ROCK2 decreased following P. emblica administration.

Conclusion:
P. emblica regulates BDNF/PI3K pathway to modulate glutathione in ischemic
stroke to confer mitoprotection and neuroprotection.
Hematotoxicity of Co-Administration of Bisphenol A and Acetaminophen in
Rats and its Amelioration by Melatonin
Authors: Akhter Mohammad S. , Rashid Hina , Hamali Hassan A. , Alshahrani Saeed , Dobie Gasim , Qadri Marwa , Madkhali Aymen M. , Mobarki Abdullah A. 
Published: June 2022

Background:
Hematotoxicity is an underexplored end point of toxicity in most of the chemical exposures. An adverse effect on the hematological system arising out of xenobiotic exposure causes impaired hemostasis and coagulation leading to disease. BPA and acetaminophen are widely used synthetic chemicals the world over and both are known and have numerous toxic effects. Since both can be simultaneously exposed to humans over a period of time, we hypothesized that their exposure can cause hematotoxicity, which may be ameliorated by melatonin.

Objective:
In the current study, we aimed to find the effect of single and co-treatment of bisphenol A and acetaminophen on the RBC and coagulation factors in rats and amelioration of impairment by melatonin.

Methods:
Oxidative stress in red blood cells, bleeding time, blood clotting time, prothrombin time, and partial thromboplastin time, and fibrinogen levels were assessed as indicators of hematotoxicity. With treatment of bisphenol A and acetaminophen as single and co treatments and amelioration of the same by melatonin was evaluated.

Results:
An increase in RBC oxidative stress and decrease in bleeding time, blood clotting time, prothrombin time, and partial thromboplastin time along with an increase in fibrinogen levels was observed with bisphenol A and acetaminophen treatment, which was further aggravated with co-treatment of the two. Melatonin treatment, however, was seen to decrease the increase in oxidative stress and ameliorate the impairment in coagulation factors.

Conclusion:
Bisphenol A and acetaminophen cause an increase in oxidative stress in the red blood cells and cause a shift towards pro-coagulation, which is alleviated by treatment with melatonin.
O poema imortal de Christian Bök
Authors: Santos Andressa Nunes , Grando Diego 
Published: June 2022

Christian Bök é um escritor e poeta conceitual canadense, professor de Escrita Criativa na Universidade de Melbourne, na Austrália. Na esteira de outros poetas conceituais que deram início ao campo de produção da arte transgênica, Bök engendrou um projeto híbrido entre as áreas da poesia e da biologia a fim de criar um poema vivo e imortal. Através de uma formação autodidata nas áreas de biologia molecular, biogenética e engenharia genética, o poeta desenvolveu, em teoria, uma forma de escrever um pequeno poema e introduzi-lo no DNA de uma bactéria resistente ao fogo, à água, à radiação e à própria explosão do Sol, capaz de sobreviver, inclusive, no espaço sideral. Além disso, parte do seu projeto era induzir a bactéria a ler o poema original e a produzir um verso poético em resposta. Este artigo descreve como Christian Bök comprovou em laboratório a viabilidade da sua teoria ao escrever um verso no DNA de uma bactéria modelo para estudos genéticos, a Escherichia coli, e obter dela, na sequência, um verso em resposta.
Representações de um passado deslembrado. A infância no exílio político nos filmes de Flávia Castro
Authors: Natalino Laís Gonçalves 
Published: June 2022

Sabe-se que os exilados nutrem uma constante necessidade de reconstruir sua identidade (Said 2003) e, por vezes, têm a tarefa de desconstruir e reorganizar narrativas que cultivem a memória. A memória, por conseguinte, se configura como uma interpretação do passado e, portanto, como um processo de reconstrução deste passado a partir do presente e através da(s) linguagem(ens). Partindo do conceito de geração pós-memorial de Hirsch (2012), o presente artigo tem como objetivo analisar as narrativas fílmicas Diário de uma busca (2010) e Deslembro (2018), destacando a transmeabilidade entre a ficção e o real e aludindo ao binômio memória e história. Para tanto, ancoro-me na concepção de tradução como recriação, representação e reprodução de memórias e fundamento minhas discussões em abordagens teóricas que se referem a processos de adaptação cultural e tradução intersemiótica. Em suma, a pesquisa observa as semelhanças e diferenças na construção das narrativas e no modo como a realizadora Flávia Castro traduz suas memórias da ditadura brasileira e do exílio político em diferentes formatos fílmicos, a saber, em um documentário e em uma ficção.
Os Autrans outros. Os muitos autores de um autor
Authors: Guimarães Jonatas 
Published: June 2022

O século XX assistiu a um sistemático apagamento do sujeito no campo da teoria e da filosofia, que levaram a uma visão da literatura como linguagem dessubjetivada. Nesse contexto, nomes como Roland Barthes e Michel Foucault propuseram reflexões que viriam a abalar a noção de autor enquanto sujeito individual determinado social e historicamente e que seria dotado de capacidade criativa e de poder fundador. Contudo, observar os processos por meio dos quais os escritores automodelam sua própria imagem oferece a possibilidade de revisão desse desmanche do sujeito e do autor na literatura, permitindo visualizar a figura autoral como conjunto diverso de máscaras carregadas de significação social. É enquanto conjunto de máscaras em aliança e em tensão que Autran Dourado empreende a automodelagem de suas diversas personas. Dessa forma, analisarei a construção da figura autoral no livro O meu mestre imaginário, assinado por Erasmo Rangel, alter ego do autor, além de discutir as várias máscaras por que se apresenta em artigos publicados em jornais e revistas, bem como nos livros de ensaios teóricos do escritor.
Nova Roma e Nova Lusitânia: o Império Português nas obras de Camões e Gândavo
Authors: Batista Bianca Dorothéa 
Published: June 2022

O objetivo deste artigo é analisar os conceitos de expansão marítima e império nas obras Os Lusíadas (1572), de Luís de Camões, e História da Província de Santa Cruz a que vulgarmente chamamos Brasil (1576), de Pero Magalhães de Gândavo. Camões defende que as viagens portuguesas às Índias projetaram Portugal como um novo império, uma Nova Roma, um império baseado no modelo romano, mas superior em conquistas e na língua. Gândavo, por sua vez, defende que a descoberta do Brasil projetou Portugal como um novo império na era moderna e, com isso, um novo modelo imperial a ser imitado e implementado, Nova Lusitânia.
Máxima visibilidade. O 'tradutor celebridade' no Brasil
Authors: Hanes Vanessa Lopes Lourenço 
Published: June 2022

Apesar de o que Venuti (1995) chama de invisibilidade do tradutor revelar muito sobre o polissistema literário global, o oposto também acontece, mas esta perspectiva contrária é muito negligenciada. Este artigo apresenta três casos brasileiros que revelam diferentes facetas desta curiosa dinâmica mercadológica: (1) um romance de Agatha Christie no qual a tradutora, Clarice Lispector, tem tanta proeminência paratextual quanto a própria autora; (2) uma versão brasileira de muito destaque da tradução de Beowulf feita por Tolkien, ou seja, uma revivificação da tradução indireta motivada pelo mercado; e (3) Tradutores, uma série da editora Hedra que traz traduções feitas por renomados escritores lusófonos. Esta pesquisa demonstra a complexa rede de fatores envolvidos na visibilização de um tradutor no Brasil, fatores os quais podem também ocorrer em outros sistemas nacionais e internacionais.
Caracterización morfológica y dasométrica de Mimosa trianae y Cassia moschata de la colección de AGROSAVIA
Authors: Castañeda Garzón Sandra L. , Moreno Barragán Jessica , Argüelles Cárdenas Jorge H. , Camargo Tamayo Hebert , Zuluaga Peláez Jhon J. 
Published: June 2022

El cañafístulo (Cassia moschata Kunth) y el yopo (Mimosa trianae Benth.) son especies nativas de importancia económica en la Orinoquia Colombiana, sin embargo, se desconoce su variabilidad genética y su comportamiento en un sistema de monocultivo. En una plantación de siete años ubicada en el Centro de Investigación La Libertad (Villavicencio, Meta), se evaluó la variabilidad fenotípica de 108 árboles de M. trianae y 52 árboles de C. moschata empleando 37 descriptores cuantitativos y cualitativos de planta (copa, fuste, hoja). Se empleó un análisis de componentes principales y correspondencias múltiples, para las variables cuantitativas y cualitativas respectivamente, con el fin de reducir la dimensionalidad del conjunto de datos, complementados con un análisis de conglomerados, mediante el algoritmo de WARD. C. moschata presentó menor porte y una copa menos vigorosa, en comparación a M. trianae que se destacó por mayor número ramas, diámetro de copa, volumen de madera e incremento medio anual de la altura total y del diámetro del fuste. El análisis de conglomerados permitió clasificar los individuos de C. moschata y M. trianae en seis y cinco grupos respectivamente, reteniendo el 99.92% y el 99.58% de la variabilidad original. Para la selección de árboles maderables y su uso en sistemas agroforestales, las variables volumen de tronco, diámetro de copa, número de ramas y altura total, son las más importantes. En M. trianae el número de foliolos por hoja y el tamaño de las hojas son variables igualmente relevantes para selección de árboles de sombrío.