bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reabsorción radicular asociada a tratamientos de ortodoncia con extracciones dentales: revisión de la literatura
Authors: Veloz Gutiérrez Pricila Katerine , Lima Illescas Miriam Verónica 
Published: July 2022

La reabsorción radicular ha sido una condición asociada con un proceso fisiológico o patológico que resulta en la pérdida de dentina, cemento o hueso, producida como un efecto indeseado pero inevitable en el tratamiento ortodóncico. El objetivo de esta revisión es analizar la literatura sobre la reabsorción radicular producida en el cierre de espacios durante el tratamiento de ortodoncia con extracciones dentales. Se realizó una búsqueda electrónica en las siguientes bases de datos: PubMed, Science Direct, BVS Regional y Cochrane. Los criterios de elegibilidad incluyeron estudios relacionados al tema de la revisión, en inglés y español, con restricción en las publicaciones de los últimos 5 años, de libre acceso, texto completo, estudios descriptivos, casos y controles, cohortes, ensayos clínicos, revisiones sistemáticas y metaanálisis. Se eligieron 27 para ser analizados. La mayor parte de autores coinciden en que existen factores, que se deben tener en cuenta en el riesgo de producir reabsorción radicular en distintos grados, estos son tratamientos de ortodoncia con extracciones dentales, debido a que en la fase de cierre de espacios se produce gran movimiento de los dientes, por la distancia que estos deben recorrer, y el tiempo de duración de la terapia. La reabsorción radicular afecta principalmente a los incisivos maxilares.
Improving the Academic English Achievement through Developing Students’ Self-Efficacy of Verbal Persuasions; A Classroom Action Research
Authors: Situmorang Komilie 
Published: July 2022

Self-efficacy is a drive within students that affects their thinking, feeling, motivation, and learning activities to achieve what they need. It is said to be one of the predictors of academic success leading to its urgency put into research. The study is classroom action research aiming to improve the nursing students' scores in Academic English class by raising the students’ self-efficacy through giving verbal persuasions. This action research was designed following Kemmis and McTaggarts’ model, including Planning, Action, Observation, and Reflection. 42 participants were also active students in the class of Academic English. After completing the sessions, the students were given pre-and posttest and asked to reflect on their achievements. The findings indicate that the average scores increased by 25 points between pre-and-posttest, 83.33% of participants had increased self-confidence, and 90.47% were satisfied with their test results. Further, the study shows score improvement through review, restudy, and re-try, pointing out the emergence of self-efficacy, which is not instant. It is a result of consistency and belief through the verbal persuasion given by the teacher.
Xunzi’nın Düşünce Sisteminde Yasanın Karakteri ve Ritüeller ile İlişkisi Üzerine Bir İnceleme
Authors: BEDEL Burçin 
Published: July 2022

Xunzi, Çin’in Zhou Hanedanlığı (MÖ 1111/ 1027- 249) döneminin Savaşan Devletler (战国) olarak adlandırılan döneminde (MÖ 480/ 403- 222) yaşamıştır. Düşünür, Konfüçyanizm (Ru Ekolü) temsilcilerinden biri olarak görülmektedir. Yaşadığı dönemde, Çin’deki pek çok düşünür gibi Xunzi da toplumda ve devlette düzen kurmak amacıyla bir düşünce sistemi geliştirmiştir. Bu düşünce sistemi ritüeller (礼, Lǐ) ve yasanın (法, Fǎ) birlikte işlediği bir yönetim sistemidir. Düşünür bu şekilde daha önce ileri sürülen görüşlerden farklı olarak iki ayrı yönetim sistemini bir araya getirmiştir. Xunzi’nın ritüellerin yanı sıra yasaya da önem vermiş olması, onun farklı bir ekole dahil edilmesi gerektiği görüşünü ortaya çıkarmıştır. Bunun sebebi Xunzi’nın ritüeller düşüncesinin Ru Ekolünün doktrini, yasa düşüncesinin ise Fa Ekolünün (legalizm) doktrini olarak ele alınması ve ritüeller ile yasa arasındaki hiyerarşinin farklı araştırmacılar tarafından farklı şekillerde değerlendirilmesidir. Ancak bu yaklaşımlar Xunzi düşüncesini tam olarak yansıtmamaktadır. Bu nedenle bu çalışmada, Xunzi düşüncesinde yasanın karakteri incelenmiş, bunun ritüeller ile ilişkisi değerlendirilerek Xunzi’nın siyaset düşüncesine farklı bir bakış açısı sunulmuştur.
ANALISIS KINERJA APARATUR DALAM MENINGKATKAN PELAYANAN PEMBUATAN KARTU KELUARGA DI KECAMATAN JATIBARANG KABUPATEN INDRAMAYU
Authors: Karomah Siti , Machmud I , Yusuf A Rifai 
Published: July 2022

AbstrakPenelitian ini dilatarbelakangi oleh buruknya citra birokrasi pemerintah dalam pelayanan masyarakat dengan proses yang lama, kurang transparan dalam memberikan informasi tarif pelayanan, dan banyaknya pungutan liar yang kerap kali menjadi masalah kritis dalam sistem pelayanan Pembuatan Kartu Keluarga. Penelitian ini diarahkan untuk mengetahui efisiensi pelayanan birokrasi dalam memberikan pelayanan umum di Kecamatan Jatibarang, apa yang menjadi faktor pendukung pelayanan, serta hambatannya.Metode penelitian yang digunakan yaitu kualitatif melalui pendekatan deskriptif dengan mengambil lokasi penelitian di Kecamatan Jatibarang Kabupaten Indramayu. Sedangkan yang menjadi (key informan) adalah Kepala Seksi Pelayanan Umum dan Camat Jatibarang, sedangkan staf Kasi Pelayanan Umum di Kecamatan Jatibarang dan masyarakat Kecamatan Jatibarang di jadikan InformanPendukung, Teknik pengumpulan data yang digunakan yaitu studi kepustakaan, observasi, dan wawancara.Hasil penelitian menjunjukan bahwa kinerja Aparatur di Kecamatan Jatibarang ada 2 konsep/aspek kajian yaitu kinerja dan pelayanan publik, dari konsep kinerja mempunyai tiga dimensi yaitu Hasil Kerja, Perilaku Kerja, dan Sifat pribadi yang ada hubungannya dengan pekerjaan dari ketiga dimensi tersebut hanya satu dimensi yang di terapkan yaitu sifat pribadiyang ada hubungannya dengan pekerjaan. Sedangkan dari konsep/aspek kajian pelayanan publik memiliki enam dimensi yaitu prosedur pelayanan, waktu penyelesaian, biaya pelayanan, produk pelayanan, sarana dan prasarana, dan kompetensi petugas pemberi pelayanan. Dari keenam dimensi pelayanan tersebut keenamnya belum tercapai seperti waktu penyelesaian sangat lambat dan terlihat menunda nunda pekerjaan dan sarana prasarana yang kurang memadai hal ini terjadi pada peralatan di ruang pelayanan kantor Kecamatan Jatibarang. Sehingga kinerja Aparatur dalam meningkatkan pelayanan pembuatan Kartu Keluarga kurang Optimal.
Simazine Enhances Dark Fermentative H2 Production by Unicellular Halotolerant Cyanobacterium Aphanothece halophytica
Authors: Pansook Sunisa , Incharoensakdi Aran , Phunpruch Saranya 
Published: July 2022

The halotolerant cyanobacterium Aphanothece halophytica is a potential H2 producer that induces H2 evolution under nitrogen deprivation. H2 is mainly produced via the catabolism of stored glycogen under dark anaerobic condition. H2 evolution is catalyzed by O2-sensitive bidirectional hydrogenase. The aim of this study was to improve H2 production by A. halophytica using various kinds of inhibitors. Among all types of inhibitors, simazine efficiently promoted the highest H2 production under dark conditions. High simazine concentration and long-term incubation resulted in a decrease in cell and chlorophyll concentrations. The optimal simazine concentration for H2 production by A. halophytica was 25 µM. Simazine inhibited photosynthetic O2 evolution but promoted dark respiration, resulting in a decrease in O2 level. Hence, the bidirectional hydrogenase activity and H2 production was increased. A. halophytica showed the highest H2 production rate at 58.88 ± 0.22 µmol H2 g−1 dry weight h−1 and H2 accumulation at 356.21 ± 6.04 μmol H2 g−1 dry weight after treatment with 25 µM simazine under dark anaerobic condition for 2 and 24 h, respectively. This study demonstrates the potential of simazine for the enhancement of dark fermentative H2 production by A. halophytica.
Performance of a Three-Dimensional Electrochemical Reactor (3DER) on Bisphenol A Degradation
Authors: Ren Xu , Song Kai , Zhang Qiaoyun , Xu Linghan , Yu Zhuyi , Tang Peixin , Pan Zhicheng 
Published: July 2022

This study constructed a three-dimensional electrochemical reactor (3DER) using meshed stainless steel sheets and titanic magnetite particles (TMP) to investigate bisphenol A (BPA) degradation through the synergistic action of electrical current and TMP. We examined some TMP characteristics, such as particle size, specific surface areas, X-ray diffraction, surface imaging, elemental constituents, and electrical resistivity. It was found that TMP was a micron-level material with excellent electrical conductivity, and it could be regarded as a magnetite-based material comprising Fe(II) and Fe(III). The single-factor experiment determined the optimal conditions for BPA removal in 3DER, specifically by introducing 200 ml of BPA-simulated wastewater (10 mg L−1) into 3DER. At the initial pH of 9.00, current and electrodes gap of 300 mA and 15 mm, respectively, and adding 1 ml of 0.5 M potassium peroxymonosulfate and 1 g TMP, &gt; 98% of BPA was removed after 55 min of electrochemical reaction. In addition, liquid chromatography–mass spectrometry identified the intermediates formed during the BPA treatment, showing two possible pathways for BPA degradation. The final degradation intermediates were chain organics with simple molecular structures. This research provided an understanding of the potential application of 3DER for BPA removal in water.
Metagenome Analysis of the Bacterial Characteristics in Invasive Klebsiella Pneumoniae Liver Abscesses
Authors: Zhang Zhijie , Wang Hairui , Guo Yawen , Liu Zhaoyu , Chang Zhihui 
Published: July 2022

BackgroundKlebsiella pneumoniae liver abscess (KPLA) combined with extrahepatic migratory infection (EMI) is defined as invasive KPLA (IKPLA) and is associated with a poor prognosis. The mechanism of IKPLA formation is yet to be elucidated. In this study, metagenomic sequencing was used to compare the bacterial characteristics between IKPLA and KPLA to explore the underlying mechanism of invasiveness.MethodsClinical details, imaging, and microbial features were retrospectively evaluated by medical record review. Metagenomic sequencing was performed on the pus samples of liver abscesses whose culture results were indicative of monomicrobial Klebsiella pneumoniae (K. pneumoniae). Bacterial diversity and composition in IKPLA and KPLA were comparatively analyzed, and the key pathways and genes that may affect invasiveness were further explored.ResultsSixteen patients were included in this study. Five patients with EMI were included in the IKPLA group, and the other eleven patients without EMI were assigned to the KPLA group. There was no statistical difference in the hypermucoviscous phenotype and serotype of K. pneumoniae between the two groups. The bacterial diversity of IKPLA was lower than that of KPLA. The abundant taxa in the IKPLA group were primarily species of unclassified Enterobacteriaceae and K. pneumoniae. The KPLA group had a high abundance of the genera Tetrasphaera and Leuconostoc. Metabolic pathway genes represented most of the enriched genes in IKPLA. Fourteen pathogenic genes with significant differences in abundance were identified between the two groups, including ybtS, fepC, phoQ, acrB, fimK, magA, entC, arnT, iucA, fepG, oqxB, entA, tonB, and entF (p &lt; 0.001).ConclusionThe diversity and bacterial composition of IKPLA were significantly different from those of KPLA. Microbiological changes in the abscess, activation of the related metabolic pathways, and the pathogenic gene expression may constitute a novel mechanism that regulates the invasiveness of KPLA.
Low α2-Plasmin Inhibitor Antigen Levels on Admission Are Associated With More Severe Stroke and Unfavorable Outcomes in Acute Ischemic Stroke Patients Treated With Intravenous Thrombolysis
Authors: Székely Edina Gabriella , Orbán-Kálmándi Rita , Szegedi István , Katona Éva , Baráth Barbara , Czuriga-Kovács Katalin Réka , Lóczi Linda , Vasas Nikolett , Fekete István , Fekete Klára , Berényi Ervin , Oláh László , Csiba László , Bagoly Zsuzsa 
Published: July 2022

BackgroundIntravenous administration of recombinant tissue plasminogen activator (rt-PA) fails to succeed in a subset of acute ischemic stroke (AIS) patients, while in approximately 6–8% of cases intracerebral hemorrhage (ICH) occurs as side effect.ObjectiveHere, we aimed to investigate α2-plasmin inhibitor (α2-PI) levels during thrombolysis and to find out whether they predict therapy outcomes in AIS patients.Patients/MethodsIn this prospective, observational study, blood samples of 421 AIS patients, all undergoing i.v. thrombolysis by rt-PA within 4.5 h of their symptom onset, were taken before and 24 h after thrombolysis. In a subset of patients (n = 131), blood was also obtained immediately post-lysis. α2-PI activity and antigen levels were measured by chromogenic assay and an in-house ELISA detecting all forms of α2-PI. α2-PI Arg6Trp polymorphism was identified in all patients. Stroke severity was determined by NIHSS on admission and day 7. Therapy-associated ICH was classified according to ECASSII. Long-term outcomes were defined at 3 months post-event by the modified Rankin Scale (mRS).ResultsMedian α2-PI activity and antigen levels showed a significant drop immediately post-lysis and increased to subnormal levels at 24 h post-event. Admission α2-PI levels showed a significant negative stepwise association with stroke severity. Patients with favorable long-term outcomes (mRS 0–1) had significantly higher admission α2-PI antigen levels (median:61.6 [IQR:55.9–70.5] mg/L) as compared to patients with poor outcomes (mRS 2–5: median:59.7 [IQR:54.5–69.1] and mRS 6: median:56.0 [IQR:48.5–61.0] mg/L, p &lt; 0.001). In a Kaplan–Meier survival analysis, patients with an α2-PI antigen in the highest quartile on admission showed significantly better long-term survival as compared to those with α2-PI antigen in the lowest quartile (HR: 4.54; 95%CI:1.92–10.8, p &lt; 0.001); however, in a multivariate analysis, a low admission α2-PI antigen did not prove to be an independent risk factor of poor long-term outcomes. In patients with therapy-related ICH (n = 34), admission α2-PI antigen levels were significantly, but only marginally, lower as compared to those without hemorrhage.ConclusionsLow α2-PI antigen levels on admission were associated with more severe strokes and poor long-term outcomes in this cohort. Our results suggest that in case of more severe strokes, α2-PI may be involved in the limited efficacy of rt-PA thrombolysis.
Quality of reporting in AI cardiac MRI segmentation studies – A systematic review and recommendations for future studies
Authors: Alabed Samer , Maiter Ahmed , Salehi Mahan , Mahmood Aqeeb , Daniel Sonali , Jenkins Sam , Goodlad Marcus , Sharkey Michael , Mamalakis Michail , Rakocevic Vera , Dwivedi Krit , Assadi Hosamadin , Wild Jim M. , Lu Haiping , O’Regan Declan P. , van der Geest Rob J. , Garg Pankaj , Swift Andrew J. 
Published: July 2022

BackgroundThere has been a rapid increase in the number of Artificial Intelligence (AI) studies of cardiac MRI (CMR) segmentation aiming to automate image analysis. However, advancement and clinical translation in this field depend on researchers presenting their work in a transparent and reproducible manner. This systematic review aimed to evaluate the quality of reporting in AI studies involving CMR segmentation.MethodsMEDLINE and EMBASE were searched for AI CMR segmentation studies in April 2022. Any fully automated AI method for segmentation of cardiac chambers, myocardium or scar on CMR was considered for inclusion. For each study, compliance with the Checklist for Artificial Intelligence in Medical Imaging (CLAIM) was assessed. The CLAIM criteria were grouped into study, dataset, model and performance description domains.Results209 studies published between 2012 and 2022 were included in the analysis. Studies were mainly published in technical journals (58%), with the majority (57%) published since 2019. Studies were from 37 different countries, with most from China (26%), the United States (18%) and the United Kingdom (11%). Short axis CMR images were most frequently used (70%), with the left ventricle the most commonly segmented cardiac structure (49%). Median compliance of studies with CLAIM was 67% (IQR 59–73%). Median compliance was highest for the model description domain (100%, IQR 80–100%) and lower for the study (71%, IQR 63–86%), dataset (63%, IQR 50–67%) and performance (60%, IQR 50–70%) description domains.ConclusionThis systematic review highlights important gaps in the literature of CMR studies using AI. We identified key items missing—most strikingly poor description of patients included in the training and validation of AI models and inadequate model failure analysis—that limit the transparency, reproducibility and hence validity of published AI studies. This review may support closer adherence to established frameworks for reporting standards and presents recommendations for improving the quality of reporting in this field.Systematic Review Registration[www.crd.york.ac.uk/prospero/], identifier [CRD42022279214].
Cuproptosis-Associated lncRNA Establishes New Prognostic Profile and Predicts Immunotherapy Response in Clear Cell Renal Cell Carcinoma
Authors: Xu Shengxian , Liu Dongze , Chang Taihao , Wen Xiaodong , Ma Shenfei , Sun Guangyu , Wang Longbin , Chen Shuaiqi , Xu Yong , Zhang Hongtuan 
Published: July 2022

Background: Clear cell renal cell carcinoma (ccRCC) accounts for 80% of all kidney cancers and has a poor prognosis. Recent studies have shown that copper-dependent, regulated cell death differs from previously known death mechanisms (apoptosis, ferroptosis, and necroptosis) and is dependent on mitochondrial respiration (Tsvetkov et al., Science, 2022, 375 (6586), 1254–1261). Studies also suggested that targeting cuproptosis may be a novel therapeutic strategy for cancer therapy. In ccRCC, both cuproptosis and lncRNA were critical, but the mechanisms were not fully understood. The aim of our study was to construct a prognostic profile based on cuproptosis-associated lncRNAs to predict the prognosis of ccRCC and to study the immune profile of clear cell renal cell carcinoma (ccRCC).Methods: We downloaded the transcriptional profile and clinical information of ccRCC from The Cancer Genome Atlas (TCGA). Co-expression network analysis, Cox regression method, and least absolute shrinkage and selection operator (LASSO) method were used to identify cuproptosis-associated lncRNAs and to construct a risk prognostic model. In addition, the predictive performance of the model was validated and recognized by an integrated approach. We then also constructed a nomogram to predict the prognosis of ccRCC patients. Differences in biological function were investigated by GO, KEGG, and immunoassay. Immunotherapy response was measured using tumor mutational burden (TMB) and tumor immune dysfunction and rejection (TIDE) scores.Results: We constructed a panel of 10 cuproptosis-associated lncRNAs (HHLA3, H1-10-AS1, PICSAR, LINC02027, SNHG15, SNHG8, LINC00471, EIF1B-AS1, LINC02154, and MINCR) to construct a prognostic prediction model. The Kaplan–Meier and ROC curves showed that the feature had acceptable predictive validity in the TCGA training, test, and complete groups. The cuproptosis-associated lncRNA model had higher diagnostic efficiency compared to other clinical features. The analysis of Immune cell infiltration and ssGSEA further confirmed that predictive features were significantly associated with the immune status of ccRCC patients. Notably, the superimposed effect of patients in the high-risk group and high TMB resulted in shorter survival. In addition, the higher TIDE scores in the high-risk group suggested a poorer outcome for immune checkpoint blockade response in these patients.Conclusion: The ten cuproptosis-related risk profiles for lncRNA may help assess the prognosis and molecular profile of ccRCC patients and improve treatment options, which can be further applied in the clinic.
Factors Affecting Burrow Architecture of the Polychaete Perinereis Aibuhitensis
Authors: He Wei , Fang Jinghui , Zhang Yitao , Yan Yisu , Zhang Zhixin , Huang Junhang , Fang Jianguang , Mao Yuze , Jiang Zengjie , Wang Junwei 
Published: July 2022

Bioturbation of infauna plays an important role in the biogeochemical processing of sediments. Infaunal animals build burrows and enlarge the sediment-water interface by their activities and so bioturbation is closely related with burrow structure and animal behavior in the sediment. The purpose of this study is to explore the characteristics of Perinereis aibuhitensis burrow structures with the factors of months and animal sizes (0-1g, 1-2g, 2-3g, 3-4g, and &gt;4g), which would also provide useful knowledge of infauna behavioral ecology. The dimension and complexity of the burrows of P. aibuhitensis were measured by dissecting sediments. The results showed that there were three burrow shapes of P. aibuhitensis, i.e., I, Y and U shapes. Overall, the order of abundance of each of the three burrow shapes were I &gt; Y &gt; U. Larger P. aibuhitensis are inclined to build Y- and U-shaped burrows in June and August. There were significant differences in the tunnel diameter, burrow depth and burrow length separately between different polychaete size classes (P&lt; 0.001). In February and August, the burrow depths and burrow lengths of P. aibuhitensis individuals with body weights of 1-2 g and 2-3 g were significantly greater than in other months (P&lt; 0.001). P. aibuhitensis individuals of 1-2 g and 3-4 g body weight had significantly more burrow openings and branches in August than in February (P&lt; 0.001). Within the same month, the burrow HEindex increased with increasing polychaete size, and when the sizes were 1-2 g, 2-3 g and 3-4 g, the complexity in August was higher than that in other months. This study suggests that I-shaped burrow dominants the burrow architecture of P. aibuhitensis. The polychaete with large size has a higher HEindex (burrow complexity) indicating a strong bioturbation ability. Y-shaped burrows are more conducive to the survival of P. aibuhitensis in hot weather. In order to adapt to environmental stresses outside, P. aibuhitensis usually builds deeper burrows.
Diversity of Deep-Sea Echinoderms From Costa Rica
Authors: Alvarado Juan José , Chacón-Monge José Leonardo , Azofeifa-Solano Juan Carlos , Cortés Jorge 
Published: July 2022

Echinoderms are a highly diverse group and one of the most conspicuous in the deep sea, playing ecological key roles. We present a review about the history of expeditions and studies on deep-sea echinoderms in Costa Rica, including an updated list of species. We used literature and information gathered from the databases of the California Academy of Sciences, the Benthic Invertebrate Collection of the Scripps Institution of Oceanography, the National Museum of Natural History, the Museum of Comparative Zoology and the Museo de Zoología from the Universidad de Costa Rica. A total of 124 taxa (75 confirmed species) have been collected from the Costa Rican deep sea, 112 found in the Pacific Ocean, 13 in the Caribbean Sea, and one species shared between the two basins. We report 22 new records for the Eastern Tropical Pacific, 46 for Central American waters, and 58 for Costa Rica. The most specious group was Ophiuroidea with 37 taxa, followed by Holothuroidea (34 taxa), Asteroidea (23 taxa), Echinoidea (17 taxa), and Crinoidea (11 taxa). The highest number of species (64) was found between 800 m and 1200 m depth. Only two species were found deeper than 3200 m. Further efforts on identification will be required for a better comprehension of the diversity of deep-sea echinoderms. Limited research has been done regarding the biology and ecology of deep-sea echinoderms in Costa Rica, so additional approaches will be necessary to understand their ecological functions.