bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hubungan antara Pendapatan dan Pola Kunjungan pada Kawasan Wisata Kuliner di Indonesia
Authors: Sukardi Arisa Aulia R. , Kusuma Hanson E. , Riska Annisa Safira 
Published: September 2022

Perkembangan pariwisata yang sangat pesat merupakan salah satu pendorong pertumbuhan ekonomi suatu negara. Keanekaragaman kuliner di Indonesia menyimpan potensi pariwisata yang besar untuk dikembangkan. Kawasan wisata kuliner merupakan sebuah kawasan wisata yang tidak hanya menyediakan ragam kuliner tetapi aktivitas lain yang dapat mendukung kegiatan berwisata seperti area berolahraga, arena bermain, area hiburan, tempat berbelanja dan lain-lain. Sehingga dalam menyusun perencanaan pengembangan kawasan wisata yang optimal maka perlu untuk mengetahui pola kunjungan wisawatan. Tujuan penelitian ini adalah untuk mengetahui pola kunjungan masyarakat di kawasan wisata kuliner berdasarkan penghasilan yang mereka dapatkan. Penelitian ini dilakukan dengan metode kualitatif – eksploratif. Data dikumpulkan dengan kuesioner daring yang berisi pertanyaan terbuka dan tertutup. Hubungan antara data kegiatan, intensitas, durasi, mitra dan tingkat pendapatan dianalisis dengan analisis korespondensi. Hasil penelitian mengungkapkan bahwa masyarakat dengan kategori pendapatan Lower Middle Income (LMI) lebih menyukai jenis Wisata Hedonis, masyarakat dengan pendapatan Upper Middle Income (UMI) lebih menyukai jenis Wisata Atraksi, berbanding terbalik dengan masyarakat High Income (HI) justru hanya melakukan wisata yang masih berkaitan dengan produktivitas.
One of the catalysts of a country's economic success is the rapid rise of tourism. Indonesia's culinary variety has much promise for tourist development. The culinary tourism area is a tourist area that provides a variety of culinary and other activities that could support travel activities such as sports areas, playgrounds, entertainment areas, shopping places, and others. So it is vital to determine the pattern of tourist visits to compile an appropriate tourism area development plan. This research aims to figure out the pattern of community visits in culinary tourist zones dependent on the amount of money they make. The approach used in this study was qualitative - exploratory. An online questionnaire with open and closed questions was used to collect data. Correspondence analysis was used to examine the link between activity data, intensity, duration, and income levels. According to the findings, persons in the Lower Middle Income (LMI) category choose hedonic tourism. In contrast, those in the Upper Middle Income (UMI) income category favor attraction type. Those in the High Income (HI) category only conduct tours still tied to productivity.
Makna Elemen Shared Space Street Bagi Pesepeda pada Jalur Pedestrian di Koridor Komersial Pecinan Kota Magelang
Authors: Hadi Dwiwangga Sang Nalendra , Saptorini Hastuti , Fauzi Hilmi Nur 
Published: September 2022

Trotoar Timur di Koridor Komersial Pecinan Kota Magelang dimanfaatkan sebagai shared space street dimana pengguna formalnya adalah pejalan kaki dan pesepeda. Sebelum pandemik, pejalan kaki menjadi pengguna dominan. Semakin tingginya minat bersepeda khususnya saat pandemik, membuat pesepeda juga mulai mengimbangi dominansi pejalan kaki sehingga menimbulkan potensi konflik. Metode pengumpulan data dilakukan dengan mengamati fisik jalur, aktivitas yang terjadi, berpartisipasi aktif sebagai pesepeda, dan wawancara mendalam dengan pesepeda. Data diperkuat dengan studi literatur yang berkaitan dengan placemaking, makna, dan shared space street. Analisis data dilakukan berdasarkan teori placemaking oleh Relph, PPS.org, dan pendekatan menemukan makna menurut Rapoport. Makna secara semiotik dieksplisitkan pada elemen signage bagi pesepeda yang lebih lengkap, jalur yang menarik secara visual, dan koridor jalur yang dilingkupi pohon peneduh membuat elemen-elemen tersebut bermakna dalam mendukung kegiatan bersepeda, seperti bersepeda santai hingga beristirahat. Peneliti merekomendasikan penambahan street furniture yang dieksplisitkan sebagai traffic calming pesepeda untuk meminimalisir konflik yang mungkin terjadi akibat penggunaan jalur secara bersama dengan pejalan kaki.
The east sidewalk in the Magelang City Chinatown Commercial Corridor is used as a shared space street where the formal users are pedestrians and cyclists. Before the pandemic, pedestrians were the dominant users. The increasing interest in cycling, especially during a pandemic, makes cyclists also begin to balance the dominance of pedestrians, causing potential conflicts. Data collection methods were carried out by observing the physical path, the activities that occurred, actively participating as cyclists, and in-depth interviews with cyclists. The data is strengthened by literature studies related to placemaking, meaning, and shared space street. Data analysis was conducted based on the placemaking theory by Relph, PPS.org, and the meaning-finding approach according to Rapoport. Semiotic meanings are expressed in signage elements for cyclists that are more complete, visually attractive trails, and pathway corridors covered by shade trees make these elements meaningful in supporting cycling activities, such as relaxing cycling to resting. The researcher recommends adding street furniture which is explicit as a traffic calming cyclist to minimize conflicts that may occur due to the use of the lane together with pedestrians.
Association Between Low- and High-Value Medication and Hospital Referrals by General Practitioners in Patients Living with Dementia
Authors: Michalowsky Bernhard , Platen Moritz , Bohlken Jens , Kostev Karel 
Published: September 2022

Background: Previous studies revealed that low-value medication (LvM), drugs that provide little or no benefit but have the potential to cause harm, are associated with hospitalizations in dementia. Recommended medications, referred to as high-value medication (HvM), can be used alternately. However, the effect of LvM and HvM on hospitalizations is uncertain. Objective: To determine the prevalence of LvM and HvM in hospitalized and non-hospitalized patients living with dementia (PwD) and the odds for hospital referrals in PwD receiving LvM or HvM. Methods: The analysis was based on 47,446 PwD who visited a general practitioner practice between 2017 and 2019. Different guidelines were used to elicit LvM and HvM, resulting in 185 LvM and HvM related recommendations. Of these, 117 recommendations (83 for LvM, 34 for HvM) were categorized into thirteen therapy classes. The association of hospital referrals issued by general practitioners and receiving LvM or HvM was assessed using multiple logistic regression models. Results: 20.4% of PWD received LvM. Most frequently prescribed LvM were non-recommended sedatives and hypnotics, analgesics, and antidepressants. Recommended HvM were 3.4 (69.9%) more frequently prescribed than LvM. Most commonly prescribed HvM were recommended antihypertensives, antiplatelet agents, and antiarrhythmics. Both receiving LvM and receiving HvM were associated with higher odds for hospital referrals. When receiving LvM were compared to HvM, no significant differences could be found in hospital referrals. Conclusion: LvM is highly prevalent but did not cause more likely hospital referrals than HvM. Further research should focus on acute hospitalizations, not only on planned hospital referrals.
Genetic architecture of morin (pentahydroxyflavone) biosynthetic pathway in mulberry (Morus notabilis): an in silico approach
Authors: Mondal Raju , Antony Sreya , Thriveni M.C. , Thanavendan G. , Ravikumar G. , Sreenivasa B.T. 
Published: September 2022

BACKGROUND: Morin, (3,5,7,2′,4′-pentahydroxyflavone), is a polyphenolic compound belonging to bio-flavonoids and is predominantly isolated from the family Moraceae. Previous studies demonstrated the health benefits of morin using human and animal models. Despite its importance as a bioactive compound, the genetic architecture of the morin biosynthetic pathway is still unclear. OBJECTIVE: To understand the genetic architecture of the morin biosynthetic pathway, the following components were analyzed: (1) cis-responsive element (CRE)-mediated regulation, (2) microRNAs (miRNA)-mediated post-transcriptional silencing, and (3) tissue-specific in silico gene expression. METHODS: To understand the genetic architecture of morin biosynthetic pathway, in silico survey was carried out using different web servers (MorusDB, MEME suite, NCBI database, PlantCARE, and psRNATarget) and collected mRNA, protein sequences, and expressed microarray data. TBtools was employed for depicting protein and promoter motifs and the heatmap preparation of tissue-specific expression of genes involved in the morin biosynthesis. RESULTS: The current data mining study highlighted the morin biosynthetic pathway associated genes, namely, phenylalanine ammonia-lyase ( MnPAL), chalcone synthase A ( MnCSA), chalcone-flavonone isomerase ( MnCFI), and flavonoid 3′,5′-hydroxylase ( MnFH) are transcriptionally regulated by different growth, development, and stress-responsive CREs. Differential expression profiles shown MnPAL (L484_024373) and MnCFI (L484_011241) genes were upregulated across selected tissues. Moreover, miRNA-mediated post-transcriptional silencing was identified. CONCLUSIONS: This study will improve our understanding of morin biosynthesis, and it can improve production via metabolic engineering.
Do Impulse Control Disorders Impair Car Driving Performance in Patients with Parkinson’s Disease?
Authors: Fründt Odette , Fadhel Mazen , Heesen Christoph , Seddiq Zai Susan , Gerloff Christian , Vettorazzi Eik , Pöttgen Jana , Buhmann Carsten 
Published: September 2022

Background: Based on data regarding the prevalence of Parkinson’s disease (PD), the prevalence of impulsive control disorders (ICD) in PD, and the percentage of PD patients driving a car, it has to be assumed that at least 50,000 PD patients with ICD in Germany actively drive a car. However, these patients might be at risk for unsafe driving due to ICD-related dysfunctions such as failure to resist an impulse or temptation, to control an act or other altered neurobehavioral processes. Objective: This study determines the influence of ICD on driving ability in PD. Methods: We prospectively compared driving simulator performance of 23 PD patients with and 23 matched patients without ICD. ICD had to be socially compensated and presence was defined clinically for primary and questionnaire-based (QUIP-RS) for post-hoc analyses. Furthermore, between-group comparisons of driving-relevant neuropsychological tests were executed. Results: Except from a lower blinking frequency when changing lanes, overall driving safety of patients with ICD did not differ significantly from those without—regardless of the clinical or QUIP-RS-based ICD definition. ICD severity did not correlate with driving performance, but the latter correlated significantly with mean reaction times and certain neuropsychiatric tests (MoCA, TMT-A, TAP-M “flexibility” and DBQ “error”). Conclusion: Clinically compensated ICD does not seem to impair driving safety in PD patients. Rather, cognitive and attentional deficits appear to be clinical markers for driving uncertainty.
Persepsi Masyarakat Pragaan Tentang Eksistensi Radio Rasda Fm.
Authors: Ali Syaif Uddin 
Published: September 2022

Bagi stasiun radio, pendengar adalah target utama dalam menjaga eksistensi, radio sebagai media massa adalah sarana untuk menyampaikan pesan yang ditujukan pada massa atau khalayak luas. Semakin banyaknya pendengar, maka eksistensi atas radio semakin diakui oleh masyarakat. Radio harus berusaha menyajikan yang sesuai dengan minat masyarakat sehingga masyarakat tertarik mendengarkan siarannya. Radio Rasda FM menyajikan Dakwah sebagai program unggulan, sehingga bukan hanya menyampaikan informasi, hiburan, juga terdapat kajian keilmuan keagamaan yang diprogramkan oleh Rasda FM.
Permasalahan yang diangkat dalam penelitian ini adalah Persepsi Masyarakat Pragaan tentang Eksistensi radio Rasda FM. Yang dijabarkan dalam satu fokus penelitian yaitu, bagaimana persepsi masyarakat Pragaan tentang eksistensi radio Rasda FM.
Untuk mengetahui lebih dalam tentang eksistensinya yang ditanggapi masyarakat Pragaan, maka peneliti menggunakan pendekatan penelitian kualitatif lapangan. Adapun metode yang digunakan adalah metode wawancara, observasi, dan dokumentasi. Dari metode ini, kemudian peneliti olah dan analisis untuk memperoleh data atau informasi. Subjek penelitian ini didiambil dari Masyarakat Pragaan, karyawan Pondok Pesantren Al-Amien Prenduan dan kariawan radio Rasda FM. Untuk keabsahan data peneliti menggunakan triangulasi dengan membandingkan data hasil pengamatan dengan hasil wawancara dengan triangulasi antar metode yaitu membandingkan keadaan dan perspektif seseorang dengan berbagai pendapat dari para pendengar.
Adapun hasil dari penelitian ini sebagian masyarakat Pragaan masih mendengarkan radio Rasda FM sehingga radio Rasda FM masih eksis di kalangan masyarakat Pragaan. Eksistensi radio Rasda FM ditanggapi dengan positif oleh mereka, karena Rasda FM mencanangkan program dakwah sebagai siaran unggulan sehinga masyarakat bisa menyerap ilmu keagamaan meski di tengah ksibukan aktivitasnya. Akan tetapi terdapat beberapa kekurangan dari radio Rasda FM diantaranya: Pertama. Program acara tenhenti akibat pemadaman listrik. Kedua. Ketidakprofesionalnya penyiar. Ketiga kurang konsisten dalam menyelenggrakan program acara.
Digging Up the Past
Authors: Rajesh Puja 
Published: September 2022

Artist’s Statement: My piece, "Digging Up the Past," was designed to bring a sense of nostalgia and joy on two levels: the cinematic and the global. Referencing the original 1999 film The Mummy, the top sculpture of a mummy represents the common pre-Covid pastimes that we all would have experienced at one point or another, such as going to a movie. The bottom pillar/column represents the culture and diverse experiences that we have missed due to the pandemic, bringing to light our inability to travel and explore localities that differ from our own. Both of these issues are accentuated by the aging processes the column and mummy have undergone, showing the toll time has taken on all of us, especially in relation to these issues. I made this piece for ART 242. A small recording device can be switched on to let the Mummy roar using the voice from the film (as it is recorded from the 1999 movie).
Nurses’ recruitment and selection: Lessons learned from the COVID-19 pandemic in Indonesia
Authors: Nazliansyah Nazliansyah , Gunawan Joko 
Published: September 2022

The purpose of this paper is to describe the current state of the recruitment and selection of nurses in Indonesia as a reflection on the pandemic. This article may be useful for evaluating the effectiveness of the human resource management system in Indonesia. However, nurses are heroes to be appreciated.
BENCANA KEKERINGAN MEMBUAT GANGGUAN MENTAL TOKOH KITA DALAM NOVEL KERING KARYA IWAN SIMATUPANG
Authors: Haryadi Haryadi , Gunawan Gunawan , Supriatini Supriatini , Listini Listini , Parwanti Sri 
Published: September 2022

Tujuan penelitian ini adalah untuk mendeskripsikan akibat bencana kekeringan yang terjadi di daerah transmigrasi. Hal ini membuat Tokoh Kita mengalami gangguan mental. Hal-hal yang dideskripsikan adalah bentuk, penyebab, akibat, dan solusi. Metode penelitian ini adalah kualitatif dengan menggunakan metode analisis isi. Desain penelitian berupa pengajuan pertanyaan, pengumpulan data, dan penginterpretasian data. Hasil penelitian adalah sebagai berikut. (1) Bentuk gangguan mental yang dialami Tokoh Kita, yaitu depresi, halunisasi, dan skizofrenia. (2) Penyebab gangguan mental Tokoh Kita yaitu jengkel, putus asa, tinggal sendirian di perkampungan transmigrasi, dan menggali sumur sendirian. (3) Akibat gangguan mental Tokoh Kita, yaitu menyapa dengan siapa saja yang ditemui di jalan, halunisasi, dan dua kali masuk rumah sakit jiwa. (4) Solusi yang dilakukan Tokoh Kita untuk mengatasi gangguan mental, yaitu merasa menyesal dengan perbuatan yang menyimpang selama ini, meminta maaf kepada orang-orang yang pernah disakiti, bertobat, dan membangun kota.
Hubungan Pengetahuan dengan Upaya Penerapan Keselamatan dan Kesehatan Kerja (K3) pada Karyawan PT Sambas Wijaya
Authors: Prasetya Catur Bayu , Ramdani Meida Laely 
Published: September 2022

Penerapan keselamatan dan kesehatan kerja (K3) sangat penting bagi keselamatan karyawan sehingga upaya penerapan K3 terhadap karyawan dibutuhkan. Pengetahuan tentang K3 diperlukan dalam setiap perusahaan untuk meminimalisir terjadinya kecelakaan kerja akibat kelalaian karyawan. Penelitian ini bertujuan untuk mengetahui hubungan pengetahuan dengan upaya penerapan keselamatan dan kesehatan kerja (K3) pada karyawan PT Sambas Wijaya. Jenis penelitian ini adalah kuantitatif dengan teknik pendekatan cross sectional. Sampel sebanyak 65 responden karyawan PT Sambas Wijaya Purbalingga dimana pengambilan sampel menggunakan teknik purposive sampling. Sebagian besar responden berusia 33-37 tahun. Tingkat pendidikan responden sebagian besar tamatan SMA mencapai 70,8% dan sebagian besar masa kerja responden lebih dari 5 tahun mencapai 75% yang terdiri dari empat bidang pekerjaan yaitu Crusher, Asphalt Mixing Plant, Maintanance, dan Logistic. Tingkat pengetahuan tentang K3 pada responden sebagian besar sudah tinggi yaitu mencapai 44 orang (67,7%). Penerapan K3 yang dilakukan responden sebagian besar sudah baik sebesar 39 orang (60%). Analisis bivariat mengunakan uji chi-square menunjukkan bahwa ada hubungan yang signifikan antara tingkat pengetahuan K3 dengan upaya penerapan K3 pada karyawan PT Sambas Wijaya dengan nilai r hitung 12,766 > r tabel 5,9915 dan nilai p value 0,002 < α 0,05.
Modified nanofat grafting: Stromal vascular fraction simple and efficient mechanical isolation technique and perspectives in clinical recellularization applications
Authors: Girard Paul , Dulong Joelle , Duisit Jerome , Mocquard Camille , Le Gallou Simon , Chaput Benoit , Lupon Elise , Watier Eric , Varin Audrey , Tarte Karin , Bertheuil Nicolas 
Published: September 2022

Background: Nanofat grafting (NG) is a simple and cost-effective method of lipoaspirates with inter-syringe passages, to produce stromal vascular fraction (SVF) and isolate adipose-derived stem cells (ASCs). This represents a tremendous interest in the future clinical needs of tissue engineering. In this study, we optimized the NG technique to increase the yield of ASC extractions.Methods: We analyzed three groups of SVF obtained by 20, 30, and 40 inter-syringe passages. The control group was an SVF obtained by enzymatic digestion with Celase. We studied their cell composition by flow cytometry, observed their architecture by confocal microscopy, and observed immunomodulatory properties of the ASCs from each of the SVFs by measuring inflammatory markers of macrophages obtained by an ASC monocyte co-culture.Results: We have established the first cell mapping of the stromal vascular fraction of adipose tissue. The results showed that SVF obtained by 20 inter-syringe passages contains more statistically significant total cells, more cells expressing the ASC phenotype, more endothelial cells, and produces more CFU-F than the SVF obtained by 30 and 40 passages and by enzymatic digestion. Confocal microscopy showed the presence of residual adipocytes in SVF obtained by inter-syringe passages but not by enzymatic digestion. The functional study indicates an orientation toward a more anti-inflammatory profile and homogenization of their immunomodulatory properties.Conclusion: This study places mechanically dissociated SVF in the center of approaches to easily extract ASCs and a wide variety and number of other progenitor cells, immediately available in a clinical setting to provide both the amount and quality of cells required for decellularized tissues.
Engineering constructed of high selectivity dexamethasone aptamer based on truncation and mutation technology
Authors: Qin Yadi , Qin Yanan , Bubiajiaer Hayilati , Chen Fengxia , Yao Jun , Zhang Minwei 
Published: September 2022

Various biosensors based on aptamers are currently the most popular rapid detection approaches, but the performance of these sensors is closely related to the affinity of aptamers. In this work, a strategy for constructed high-affinity aptamer was proposed. By truncating the bases flanking the 59 nt dexamethasones (DEX) original aptamer sequence to improve the sensitivity of the aptamer to DEX, and then base mutation was introduced to further improve the sensitivity and selectivity of aptamers. Finally, the 33 nt aptamer Apt-M13 with G-quadruplex structures was obtained. The dissociation constant (Kd) was determined to be 200 nM by Graphene oxide (GO)-based fluorometry. As-prepared Apt-M13 was used for a label-free colorimetric aptamer sensor based on gold nanoparticles, the LOD was 3.2-fold lower than the original aptamer described in previous works. The anti-interference ability of DEX analogs is also further improved. It indicates that truncation technology effectively improves the specificity of the aptamer to DEX in this work, and the introduction of mutation further improves the affinity and selectivity of the aptamer to DEX. Therefore, the proposed aptamer optimization method is also expected to become a general strategy for various aptamer sequences.
Neddylation pattern indicates tumor microenvironment characterization and predicts prognosis in lung adenocarcinoma
Authors: Cui Yuan , Chen Zhike , Pan Bin , Chen Tong , Ding Hao , Li Qifan , Wan Li , Luo Gaomeng , Sun Lang , Ding Cheng , Yang Jian , Tong Xin , Zhao Jun 
Published: September 2022

Background: Lung adenocarcinoma (LUAD) is the most common type of lung cancer with a complex tumor microenvironment. Neddylation, as a type of post-translational modification, plays a vital role in the development of LUAD. To date, no study has explored the potential of neddylation-associated genes for LUAD classification, prognosis prediction, and treatment response evaluation.Methods: Seventy-six neddylation-associated prognostic genes were identified by Univariate Cox analysis. Patients with LUAD were classified into two patterns based on unsupervised consensus clustering analysis. In addition, a 10-gene prognostic signature was constructed using LASSO-Cox and a multivariate stepwise regression approach.Results: Substantial differences were observed between the two patterns of LUAD in terms of prognosis. Compared with neddylation cluster2, neddylation cluster1 exhibited low levels of immune infiltration that promote tumor progression. Additionally, the neddylation-related risk score correlated with clinical parameters and it can be a good predictor of patient outcomes, gene mutation levels, and chemotherapeutic responses.Conclusion: Neddylation patterns can distinguish tumor microenvironment and prognosis in patients with LUAD. Prognostic signatures based on neddylation-associated genes can predict patient outcomes and guide personalized treatment.