bluuebunny/crossref_metadata_2025_split huggingface dataset:
TICs y promoción de corresponsabilidades masculinas en el cuidado de VIH e ITSs
Authors: García Darwin 
Published: March 2022

El presente artículo nace del Proyecto de Vinculación con la Comunidad denominado: “Prevención y sensibilización en VIH/SIDA en colectivos clave del cantón Cuenca: población universitaria” auspiciado por la Universidad de Cuenca, a través de la carrera de Género y Desarrollo, el mismo que se constituye en un trabajo de investigación que aglutina a una muestra de estudiantes de las doce facultades de esta casa de estudio, este proceso investigativo radica en hacer un despistaje de los conocimiento sobre infecciones de transmisión sexual (ITSs) y VIH/SIDA, para sugerir estrategias de intervención educativa adecuadas a ser implementadas en los y las alumnas de la Universidad de Cuenca, proceso que parte desde la concepción adecuada de términos, hasta elementos que permitan desarrollar una adecuada conciencia sobre las relaciones afectivo-sexuales basadas en el autocuidado y la no violencia desde un enfoque de género, con énfasis en la prevención del VIH. Para este escrito, se toma en cuenta una de las áreas abordadas en dicho despistaje, que se relaciona con dos aspectos específicos, el primero orientado a cómo el grupo de estudiantes accede a la información relacionada con ITS/VIH, y el segundo a cómo las percepciones sobre cuidado y autocuidado son determinantes para la comprensión de las implicaciones que conlleva un adecuado sistema de prevención que parta del criterio personal como un acto sensible y responsable.
Efektivitas Penyelesaian Perkara Secara E-Court di Pengadilan Agama Kabupaten Kediri
Authors: Khofifatus Salima Safira , Safudin Endrik 
Published: March 2022

This study discusses about how the effectiveness of the e-court that runs in the Kediri Regency Religious Court. As it is understood that the e-court regulation was born because of the need for the easier, cheaper, and efficient services based on PERMA Number 1 of 2019. The formulation of the problem in this study is: How is the effectiveness of the implementation of e-court on the process of filing cases at the Religious Court of Kediri Regency, and What factors influence the implementation of e-court in the process of filing cases and e-litigation. To answer this question, the researcher uses a combination research method, where researchers can use data in the form of interviews (triangulation), and data analysis that is both deductive and inductive as well as a conceptual approach to the theory of effectiveness that will be brought by researchers in this study. From the results of this study, it can be concluded that the e-court that occurred at the Kediri Religious Court has fulfilled the effectiveness of the court in litigation. This can be seen from the fulfillment of a judicial process which is simpler, faster, and less expensive than the usual proceedings. With the existence of e-court litigation services, both justice seekers and courts can get better benefits than ordinary litigation.
Penelitian ini membahas tentang bagaimana keefektivitasan e-court yang berjalan di Pengadilan Agama Kabupaten Kediri. Sebagaimana dipahami bahwa regulasi e-court lahir karena kebutuhan pelayanan yang lebih mudah, murah, dan efisien berdasarkan PERMA Nomor 1 Tahun 2019. Rumusan masalah dalam penelitian ini adalah: Bagaimana efektivitas pelaksanaan e-court terhadap proses pengajuan perkara di Pengadilan Agama Kabupaten Kediri, dan Faktor-faktor apa yang berpengaruh terhadap pelaksanaan e-court di dalam proses pengajuan perkara dan e-litigasi. Untuk menjawab pertanyaan tersebut peneliti menggunakan metode penelitian kombinasi, dimana peneliti bisa menggunakan data baik berupa wawancara (triangulasi), dan analisis data yang bersifat deduktif maupun induktif serta pendekatan secara konseptual mengenai teori efektivitas yang akan dibawa peneliti didalam penelitian ini. Dari hasil penelitian ini dapat disimpulkan bahwa e-court yang terjadi di Pengadilan Agama Kediri sudah memenuhi keefektivitasan pengadilan dalam berperkara. Hal ini dapat dilihat dari terpenuhinya peradilan yang lebih sederhana, cepat, dan biaya ringan jika dibandingkan dengan proses beracara secara biasa. Dengan adanya layanan berperkara secara e-court, baik pihak pencari keadilan maupun pengadilan dapat memperoleh manfaat yang lebih baik daripada berperkara secara biasa.
Different AHO phenotype in a Chinese family with a novel GNAS missense mutation: a case report
Authors: ZOU Chao-Chun , Zhou Qing , Liang Bin , Fu Qing Xian , Liu Hui 
Published: March 2022

Abstract
BackgroundAlbright’s hereditary osteodystrophy (AHO) is an inherited disorder which is caused by an inactivating mutation in the GNAS gene. AHO appears in either pseudohypoparathyroidism 1a (PHP1a) when GNAS gene is maternally inherited or pseudo-pseudohypoparathyroidism (PPHP) when it is paternally inherited. Case presentationWe describe the clinical and biochemical characteristics of two patients, a boy and his mother, and identify a novel heterozygous missense variant c.1123G>T (p. Val375Leu) in the exon 13 of GNAS gene. The boy presented with typical AHO phenotype (early-onset obesity, round face, short neck, shortened fifth metacarpal bone, developmental retardation, but without short stature), multiple hormone resistance including PTH, TSH and ACTH, and mild calcification in the right basal ganglia. The mother only presented with brachydactyly and short stature, without hormone resistance and other signs of AHO. The diagnosis of PHP-1a for the son and PPHP for the mother were confirmed.Conclusion: This study further expands the spectrum of known GNAS mutations, and also demonstrates the heterogeneous phenotype of AHO due to a novel GNAS mutation.
Microstructure and mechanical properties of laser deposition manufactured a newly developed Ti-6Al-2Mo-2Sn-2Zr-2Cr-2V titanium alloy
Authors: Wang Chao , Yi Junzhen , Wang Jiaxing , Wu Jiabao , Shao Shuai , Qin Lanyun , Yang Guang 
Published: March 2022

Abstract
With the rapid development of aviation industry, the study of new type titanium alloy with superior mechanical properties is of great significance. In this paper, a newly developed Ti-6Al-2Mo-2Sn-2Zr-2Cr-2V (Ti-622222) alloy was fabricated by laser deposition manufacturing (LDM). The as-deposited Ti-622222 alloy exhibits coarse β columnar grains containing the basket-weave structure knitted with α phases and β phases. The solution and aging treatment decreases the size and content of primary α phase, but promotes the precipitation of secondary α phase. The microhardness shows a rising trend with the solution temperature increasing due to the precipitation of fine secondary α phase. The LDMed Ti-622222 alloy exhibits superior tensile strength (1025 MPa) and inferior elongation (6.0%). With the solution temperature increasing, the strength increases but the plasticity first increases and then decreases. The LDMed Ti-622222 alloy exhibits a mixed fracture mechanism of ductile and brittle fracture. The LDMed Ti-622222 alloy exhibits obvious anisotropy of impact property, the average impact toughness of the as-deposited sample in scanning direction is 23.4 J/cm2 lower than that (40.9 J/cm2) in deposition direction. After solution and aging treatment, the impact toughness improves significantly. With the solution temperature increasing, impact toughness first increases and then decreases.
BREATHS: A Novel Endotracheal Tube Design to Decrease the Incidence of Tracheal Lesions
Authors: Crowley Madeline Monahan , Lingawi Saud , Tariq Omar , Goubran Daniel , Johal Sunny , Smith Andrew , Tam Roger 
Published: March 2022

Abstract
Background
Prolonged intubation is associated with the development of tracheal stenosis due to cuff pressures causing endothelial ischemia, potentially leading to tracheal stenosis at the cuff site. This may result in airway obstructions requiring surgical intervention. Objective to develop a modification to endotracheal tube cuffs to put less pressure against the tracheal walls to decrease the risk of developing post-ventilation tracheal stenosis.
Methods
A modified endotracheal tube cuff was designed using a double balloon cuff design, with an outer fixed cuff and an inner cuff that expands and deflates with the respiratory cycle. The design allows for the cuff pressure applied to the trachea to be maximal during inspiration and minimal during expiration, coinciding with pressures required to maintain an air seal.
Results
During inspiration, the pressure on the tracheal wall is equal to that of a standard endotracheal tube. During expiration, the pressure applied on the tracheal walls is less than that of a standard endotracheal tube. The minimal pressure throughout the cycle decreased to baseline throughout the respiratory cycle due to minimal cuff inflation by the end of expiration, as most air is removed.
Conclusions
The modified cuff demonstrates an overall decreased pressure applied to the trachea, with potential to enable microvascular perfusion, improve blood flow, and decrease risk of tracheal lesions and stenosis. Further testing with more ventilatory conditions, endotracheal tube, tracheal, and lung analog sizes, and in-vivo testing efforts are required to ascertain if this innovation’s clinical benefit.
Iron-Catalyzed Ligand-Controlled Silylation or Borylation of Ni-triles with Bpin-SiEt3 via C-CN Bond Cleavage
Authors: Cao Ying , Zhang Huan , Zeng Xiaoqin , Liu Zhengli , He yun , Feng Zhang 
Published: March 2022

Abstract
The first example of iron-catalyzed ligand-controlled silylation or borylation of the same nitriles via C-CN bond cleavage using a common silylborane reagent as either the silyl or boryl source has been developed. The same nitriles can undergo silylation well with a bulky oxalic diamide ligand or borylation smoothly in the presence of P(t-Bu)3HBF4, delivering the corresponding silylated or borylated products with excellent chemoselectivities. This protocol exhibits good functional group tolerance and enables the late-stage silylation or borylation of bioactive compounds, thus offering excellent opportunities for applications in drug discovery and development.
Engineering an Oilseed Crop for Hyper-Accumulation of Carotenoids in the Seeds without Using a Traditional Marker Gene
Authors: He Ming-Xia , Wang Jie-Lin , Lin Yuan-Yuan , Liu Aizhong , Huang Jun-Chao , Chen Feng 
Published: March 2022

Abstract
Camelina sativa (L.) Crantz is an important oil crop with many excellent agronomic traits. This model oil plant has been exploited to accumulate value-added bioproducts using genetic manipulation that depends on antibiotic- or herbicide-based selection marker genes (SMG), one of the major concerns for genetically modified foods. Here we reported metabolic engineering of C. sativa to synthesize red ketocarotenoids that could serve as a reporter to visualize transgenic events without using a traditional SMG. Overexpression of a non-native β-carotene ketolase gene coupled with three other carotenogenous genes (phytoene synthase, β-carotene hydroxylase, and Orange) in C. sativa resulted in production of red seeds that were visibly distinguishable from the normal yellow ones. Constitutive expression of the transgenes led to delayed plant development and seed germination. In contrast, seed-specific transformants demonstrated normal growth and seed germination despite the accumulation of up to 70-fold the level of carotenoids in the seeds compared to the controls, including significant amounts of astaxanthin and keto-lutein. As a result, the transgenic seed oils exhibited much higher antioxidant activity. No significant changes were found in the profiles of fatty acids between transgenic and control seeds. This study provided a novel tool for metabolic engineering of seed crops without using a disputed SMG.
Child Growth Monitoring and Promotion Practice and Associated Factors among Health Care Workers at Public Health Institutions in South Wollo Zone, Northeast Ethiopia: An Institution based Cross Sectional Study
Authors: Kebede Getabalew Getachew , Ahmed Kemal , Ali Yeshimebet 
Published: March 2022

Abstract
Background
Even though Growth Monitoring and Promotion (GMP) has been practicing in many countries including Ethiopia for well children less than two years of age to prevent malnutrition, there is still a chance to acquire malnutrition in Ethiopia. However, there is no study that documented the proportion of GMP practice and associated factors in the study area. Therefore, the aim of this study was to assess GMP practice and identify associated factors among health care workers.
Methods
Institution based cross- sectional study design was employed on 397 randomly selected health care workers in South Wollo Zone, northeast Ethiopia from May 25 to July 7, 2020. Pre-tested self-administered questionnaire and in-depth interview were used to collect data. Quantitative data were analyzed using SPSS version 20.0 software. Thematic analysis was applied to the qualitative part. Bivariable and multivariable logistic regressions were used to identify associated factors with GMP practice. Statistical tests at P-value < 0.05 with 95% confidence interval were taken for statistical significance.
Results
The proportion of GMP practice among health care workers was 58.4% with (95% CI: 54.0–63.0). First degree (AOR = 2.25; 95% CI: 1.005, 5.05), diploma (AOR = 3.52; 95% CI: 2.04, 6.09), work experience on GMP (AOR = 3.13; 95% CI: 1.58, 6.20), GMP training (AOR = 4.83; 95% CI: 2.89, 8.06), GMP equipment (AOR = 2.75; 95% CI: 1.64, 4.58) and attitude towards GMP (AOR = 3.70; 95% CI: 2.228, 6.174) were factors significantly associated with GMP practice.
Conclusions
The proportion of GMP practice among health care workers was 58.4%. Educational level, work experience on GMP, GMP training, GMP equipment and attitude towards GMP were positively associated with GMP practice. Therefore, Ministry of Health should strengthen availability of GMP equipment, GMP training, and bring positive attitude towards GMP to improve GMP practice with special focus on health care workers with lower experience on GMP service.
Fabricated Hybrid Composites with Insect-Repellent Property
Authors: Babayo Hajara , Musa Haruna , Garba Mustapha D. 
Published: March 2022

Abstract
An insect repellent composite containing tiger nut particulate fibre, waste low density polyethene (LDPE) and castor oil alkyd resin (COAR) was fabricated. Canarium schweinfurthii gum used as insect repellent compound and maleic anhydride as compatibilizer. The tiger nut chaff was subjected to benzoylation using benzoyl chloride to increase fibre-matrix interaction. The compound and composition thereof moulded with LDPE as dual matrices for excellent physico-mechanical properties (pressed for 5 min, 130 °C and 25 bar and cured). Least water absorption of ~0.085 %, optimal chemical resistance for both acids (HCl and H2SO4) and bases (NaOH and KOH) and no effect on thickness was observed with the 10 wt.% treated composite. Density measurement showed the lowest value of ~0.0096 g/cm3 for the treated fibre composite. However, the tensile strength, flexural stress, hardness and impact load were improved up to 35.08 Mpa, 456.3 Mpa, 95 and 730 J/m respectively with treated composites. Insect repellent test against termites and cockroaches shows repellent activity with time intervals. FTIR and SEM analysis showed fibre modification achieved.
A redundant sensing device schedule method under event monitoring coverage constraints for edge computing
Authors: Chen Xiangwei , Long Jun , Zhang Jinhuan 
Published: March 2022

Abstract
Billions of sensing devices are deployed in the smart city to generate a large amount of sensing data for various applications. However, duplicated data caused by redundant deployed sensing devices makes it a great challenge to gather data with low cost and high efficiency. In this paper, a redundant sensing device schedule method is proposed through redundant sensing device identification scheme based on device redundancy and similarity (RSDI-DRS) under event monitoring coverage constraints. The key idea of the RSDI-DRS is to reduce the number of unnecessary working sensing device to decrease energy consumption and data load. Comparing to the previous researches, the innovation of RSDI-DRS is as follows: First, a novel sensing device redundancy and similarity calculation method is proposed. Second, the network connectivity is realized by the network connectivity discrimination scheme. In the proposed scheme, the redundant device set is established by calculating the sensing device redundancy score. Then, the device similarity score is calculated for the devices in the redundant device set, and the scheduling priority of the redundant device is obtained based on the similarity score and the remaining energy of the sensing device. The device with the maximum scheduling priority is scheduled to sleep. The process loops under the satisfaction of event coverage constraint. Meanwhile, the network connectivity is realized in the process. If an isolated sensing device occurs, the neighbor device with the minimum scheduling priority will not be scheduled to sleep. Simulation results show that the proposed scheme could prolong the network life by 16.30% ~ 31.18% and realized the connectivity of working sensing devices under the event monitoring coverage at the cost of the execution time growth compared with the scheme of Relocating Redundant Sensors-Redundant Node Identification (RRS-RNI).
Mitochondrial Phosphate Carbokinase Inhibits Renal Cell Carcinoma Malignant Progression, Leading to Cell Energy Metabolism Imbalance
Authors: Chen Yeda , Yang Shuxin , Huang Yapeng , Wang Zhu , Deng Qiong , Chen Yuting , Yu Qingfeng , Liang Hui 
Published: March 2022

Abstract
Mitochondrial phosphoenolpyruvate carboxykinase (PCK2) is a key gluconeogenesis enzyme. Its differential expression is related to renal cell carcinoma (RCC) malignancy, possibly by influencing energy metabolism.We found that, compared with 293t, PCK2 was downregulated in six RCC lines. Relative to surrounding tissues, PCK2 was downregulated in RCC. PCK2 overexpression inhibited RCC proliferation. PCK2 overexpression inhibited RCC migration and invasion. Mass spectrometry revealed that thiamine pyrophosphate, cyclic AMP, beta-D-Fructose 6-phosphate, lactate, flavin mononucleotide, NAD, NADP, D-Glucose 6-phosphate were upregulated. In conclusion, our results showed that PCK2 overexpression inhibited RCC proliferation, migration, and invasion and upregulated energy metabolite expression.
Comprehensive diagnostic criteria for MELAS syndrome: A case study involving an elderly patient with MT-TWm.5541C&gt;T mutation
Authors: Wu Gang , Shen Yuguang , Zhu Feng , Tao Weiwei , Zhou Yuanlin , Ke Shaofa , Jiang Huihua 
Published: March 2022

Abstract
Background
Mitochondrial encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) syndrome is a matrilineal hereditary multi-system disease due to mutations of mitochondrial DNA. Though the initial diagnostic criteria prevail till nowadays, which take a range of clinical phenotypes into consideration including clinical onset after the age of 40, a confirmative diagnostic standard for MELAS is still needed.
Case presentation:
A 71-year-old female patient presented with recurrent stroke to our hospital. Magnetic resonance imaging showed a cerebral gyrus-like area with hyperintensity in the parietal-occipital lobe on DWI and this area expanded with disease progression. The Lac/Lip peaks were significantly inverted in the MRS imaging. Nucleic acid sequencing showed a MT-TWm.5541C>T mutation, and the mutation rate of the blood sample was 12.86%. The patient had a 6-year history of type 2 diabetes. The patient experienced recurrent stroke and was given coenzyme Q10 capsules and idebenone tablets to improve metabolism, vitamin B to nourish nerves, edaravone to scavenge oxygen free radicals, and oxcarbazepine to manage seizures. At 1-month follow-up, her condition was stable.
Conclusion
Patients with MELAS syndrome have complex clinical manifestations. Our data demonstrated that, for patients with atypical cerebral infarction and suspected MELAS syndrome, gene sequencing and muscle biopsy should be completed in time, which may serve as a reference for the diagnostic criteria of MELAS syndrome.
Metformin has no Significant Anticancer Effect on Patients with Advanced or
Unresectable Cancer: A Systematic Review and Meta-analysis
Authors: Gan Xinyan , Cao Chang , He Yan , Hu Xiaolin , Peng Xingchen , Su Yonglin 
Published: March 2022

Background:
At present, the antitumor effect of metformin is controversial. Previous meta-analyses
included observational studies, of which the results can be influenced by many confounders, affecting the result of
meta-analyses and weakening the strength of evidence. Therefore, we conducted a meta-analysis to confirm the effect
of metformin use on patients with advanced or unresectable cancers, including randomized clinical trials (RCTs).

Methods:
We searched for RCTs in accordance with the inclusion and exclusion criteria. A meta-analysis was
conducted to combine hazard ratios (HRs) or risk ratios (RRs) and their 95% confidence intervals (CIs) using a
random-effects model.

Results:
Finally, 7 eligible RCTs were included in the meta-analysis. Overall, the combined results revealed that
treatment with metformin did not improve the overall survival (OS) of patients (HR, 1.12; 95% CI, 0.91-1.37,
p>0.05), and there was no clear evidence that metformin use was related to improved progression-free survival (PFS)
(HR, 1.17; 95% CI, 0.97-1.40; p>0.05). The pooled RR for grade III or IV adverse events was 0.92 (95% CI, 0.52-
1.60; p>0.05), indicating that the use of metformin was not significantly related to increased toxicity.

Conclusion:
Metformin does not significantly improve the survival of patients with advanced or unresectable
cancer, regardless of cancer type and region.
Open Science Framework: DOI 10.17605/OSF.IO/SPKE8.
Treatment of Adult Spinal Muscular Atrophy: Overview and Recent Developments
Authors: Brakemeier Svenja , Stolte Benjamin , Kleinschnitz Christoph , Hagenacker Tim 
Published: March 2022

Abstract:
Spinal muscular atrophy (SMA) is a rare genetic neuromuscular disease leading to progressive and,
in many cases, severe muscle weakness and atrophy in the natural disease course. An increasing number of
gene-based treatment options have become available in recent years. Growing knowledge regarding the underlying
genetic mechanisms makes the disease well amenable to them. Over the past few years, data on new
treatments, their mechanisms of action and therapeutic outcomes have been published, reflecting the current
dynamics in this field. With the approval of the antisense oligonucleotide nusinersen, the vector-based therapy
with onasemnogene abeparvovec and the small molecule splicing modifier risdiplam, three gene therapeutic
drugs are available for the treatment of SMA showing improvement in motor function. But in the pivotal studies,
several relevant parameters have not been addressed. There is a data gap for the treatment outcome of adult
individuals with SMA as well as for several other relevant outcome parameters, like bulbary or ventilatory
function. With increasing treatment options, additional individual therapies have become necessary. Studies on
combination therapies or switch of therapy, e.g., the sequential administration of onasemnogen abeparvovec
and nusinersen, are necessary. An overview of current developments in the field of therapeutic options for adult
SMA is presented. Important characteristics of each therapeutic options are discussed so that the reader can
comprehend underlying pathophysiological mechanisms as well as advantages and disadvantages of each therapy.
The focus is on gene-based treatment options, but options beyond this are also addressed.