bluuebunny/crossref_metadata_2025_split huggingface dataset:
An explainable framework for load forecasting of a regional integrated energy system based on coupled features and multi-task learning
Authors: Wu Kailang , Gu Jie , Meng Lu , Wen Honglin , Ma Jinghuan 
Published: June 2022

AbstractTo extract strong correlations between different energy loads and improve the interpretability and accuracy for load forecasting of a regional integrated energy system (RIES), an explainable framework for load forecasting of an RIES is proposed. This includes the load forecasting model of RIES and its interpretation. A coupled feature extracting strategy is adopted to construct coupled features between loads as the input variables of the model. It is designed based on multi-task learning (MTL) with a long short-term memory (LSTM) model as the sharing layer. Based on SHapley Additive exPlanations (SHAP), this explainable framework combines global and local interpretations to improve the interpretability of load forecasting of the RIES. In addition, an input variable selection strategy based on the global SHAP value is proposed to select input feature variables of the model. A case study is given to verify the effectiveness of the proposed model, constructed coupled features, and input variable selection strategy. The results show that the explainable framework intuitively improves the interpretability of the prediction model.
Assessment of phytotoxicity of selected botanical insecticides on treated cowpea (Vigna unguiculata) seed
Authors: Ogbonnaya Ewa , Rizwan Ansari Ahmad , Bamidele Emakoji Ile , Ayuba Victoria 
Published: June 2022

AbstractBackgroundSynthetic insecticides employed in seed treatment are often phytotoxic, especially at slightest misapplications. Cowpea seed is mainly attacked byCallosobruchus maculatus. It is established that azadirachtin, myristicin and α-humulene based insecticides (botanical insecticides) are eco-friendly and have activity againstC. maculatusand thus are considered ideal candidates in research efforts targeted at developing plant based options for protecting cowpea seed againstC. maculatusattack. Therefore, the aim of this study was to evaluate the toxicity of selected botanical insecticides on treated cowpea (Vigna unguiculata) seed.ResultsElectrical conductivity of leachate obtained from cowpea seed treated with botanical insecticides was significantly (P < 0.05) lower than that recorded on seed treated with chlorpyrifos. Malondialdehyde levels in seed of cowpea cultivars; SAMPEA 11 and 12 was significantly (P < 0.05) higher than that recorded on seed treated with chlorpyrifos. However, malondialdehyde levels in seed of SAMPEA 14 treated with myristicin and azadirachtin based insecticides were not significantly (P > 0.05) different from that reported for cowpea seed treated with chlorpyrifos. Less than 50% of the embryo recovered from seed treated with botanical insecticides was unstained contrary to the observation made on seed of SAMPEA 14 dressed with chlorpyrifos.ConclusionThis study reveals similarity as well as variation in varietal sensitivity to phytoxicity among the various cultivars of cowpea seed studied implying that a farmer’s choice of botanical insecticides for the protection of cowpea seed againstCallosobruchus maculatuswould strictly depend on the cultivars involved.
Three-dimensional echocardiographic assessment of Chiari’s network relationship with the left ventricular false tendon
Authors: Sumerkan Mutlu Cagan , Cetin Sukru , Helvaci Fusun Behramoglu , Yaslikaya Sendag Satilmis , Karabay Umut , Hamit Turgun , Gurdal Ahmet , Agirbasli Mehmet , Alyan Omer 
Published: June 2022

Abstract
Background
Left ventricular false tendon (LVFT) is a fibromuscular band crossing the left ventricular cavity. And Chiari’s network (CN) is a highly mobile, mesh-like, echogenic structure in right atrium. In this study, we aimed to evaluate the coexistence of LVFT in patients with CN. CN patients were examined with live/real-time three-dimensional transthoracic echocardiography (TTE) for visualization of LVFT.

Results
This is a single-center prospective study of 49 patients with CN. In literature studies, the average ratios of LVFT were 22% in the normal population. In our study, an increased ratio of LVFT (n = 31, 63.3%) was found in CN patients evaluated with a three-dimensional TTE (63.3% versus 22%) (p = 0.01). The interatrial septal aneurysm was found in 31 (63.3%) patients with CN. And, the positive contrast echocardiography examination was determined in 22 (61.1%) patients with CN.

Conclusions
Our study reveals that CN is associated with LVFT and is also associated with cardiac anomalies like an interatrial septal aneurysm, and atrial septal defect. And LVFT can be evaluated better with three-dimensional TTE than with traditional two-dimensional TTE. Patients with CN should be evaluated more carefully by three-dimensional echocardiography as they can be in synergy in terms of the cardiac pathologies they accompany.
Therapeutic potential of venom peptides: insights in the nanoparticle-mediated venom formulations
Authors: Joglekar Aditya Vivek , Dehari Deepa , Anjum Md. Meraj , Dulla Naveen , Chaudhuri Aiswarya , Singh Sanjay , Agrawal Ashish Kumar 
Published: June 2022

Abstract
Background
Venoms are the secretions produced by animals, generally for the purpose of self-defense or catching a prey. Biochemically venoms are mainly composed of proteins, lipids, carbohydrates, ions, etc., and classified into three major classes, viz. neurotoxic, hemotoxic and cytotoxic based upon their mode of action. Venoms are composed of different specific peptides/toxins which are responsible for their unique biological actions. Though venoms are generally seen as a source of death, scientifically venom is a complex biochemical substance having a specific pharmacologic action which can be used as agents to diagnose and cure a variety of diseases in humans.

Main body
Many of these venoms have been used since centuries, and their specified therapies can also be found in ancient texts such as Charka Samhita. The modern-day example of such venom therapeutic is captopril, an antihypertensive drug developed from venom of Bothrops jararaca. Nanotechnology is a modern-day science of building materials on a nanoscale with advantages like target specificity, increased therapeutic response and diminished side effects. In the present review we have introduced the venom, sources and related constituents in brief, by highlighting the therapeutic potential of venom peptides and focusing more on the nanoformulations-based approaches. This review is an effort to compile all such report to have an idea about the future direction about the nanoplatforms which should be focused to have more clinically relevant formulations for difficult to treat diseases.

Conclusion
Venom peptides which are fatal in nature if used cautiously and effectively can save life. Several research findings suggested that many of the fatal diseases can be effectively treated with venom peptides. Nanotechnology has emerged as novel strategy in diagnosis, treatment and mitigation of diseases in more effective ways. A variety of nanoformulation approaches have been explored to enhance the therapeutic efficacy and reduce the toxicity and targeted delivery of the venom peptide conjugated with it. We concluded that venom peptides along with nanoparticles can evolve as the new era for potential treatments of ongoing and untreatable diseases.

Graphical Abstract
Phase II Study of Venetoclax Added to Cladribine Plus Low-Dose Cytarabine Alternating With 5-Azacitidine in Older Patients With Newly Diagnosed Acute Myeloid Leukemia
Authors: Kadia Tapan M. , Reville Patrick K. , Wang Xuemei , Rausch Caitlin R. , Borthakur Gautam , Pemmaraju Naveen , Daver Naval G. , DiNardo Courtney D. , Sasaki Koji , Issa Ghayas C. , Ohanian Maro , Montalban-Bravo Guillermo , Short Nicholas J. , Jain Nitin , Ferrajoli Alessandra , Bhalla Kapil N. , Jabbour Elias , Takahashi Koichi , Malla Rashmi , Quagliato Kelly , Kanagal-Shamanna Rashmi , Popat Uday R. , Andreeff Michael , Garcia-Manero Guillermo , Konopleva Marina Y. , Ravandi Farhad , Kantarjian Hagop M. 
Published: June 2022

PURPOSE The combination of venetoclax and 5-azacitidine (5-AZA) for older or unfit patients with acute myeloid leukemia (AML) improves remission rates and survival compared with 5-AZA alone. We hypothesized that the addition of venetoclax to cladribine (CLAD)/low-dose araC (low-dose cytarabine [LDAC]) alternating with 5-AZA backbone may further improve outcomes for older patients with newly diagnosed AML. METHODS This is a phase II study investigating the combination of venetoclax and CLAD/LDAC alternating with venetoclax and 5-AZA in older (≥ 60 years) or unfit patients with newly diagnosed AML. The primary objective was composite complete response (CR) rate (CR plus CR with incomplete blood count recovery); secondary end points were overall survival, disease-free survival (DFS), overall response rate, and toxicity. RESULTS A total of 60 patients were treated; median age was 68 years (range, 57-84 years). By European LeukemiaNet, 23%, 33%, and 43% were favorable, intermediate, and adverse risk, respectively. Fifty-six of 60 evaluable patients responded (composite CR: 93%) and 84% were negative for measurable residual disease. There was one death (2%) within 4 weeks. With a median follow-up of 22.1 months, the median overall survival and DFS have not yet been reached. The most frequent grade 3/4 nonhematologic adverse events were febrile neutropenia (n = 33) and pneumonia (n = 14). One patient developed grade 4 tumor lysis syndrome. CONCLUSION Venetoclax and CLAD/LDAC alternating with venetoclax and 5-AZA is an effective regimen among older or unfit patients with newly diagnosed AML. The rates of overall survival and DFS are encouraging. Further study of this non–anthracycline-containing backbone in younger patients, unfit for intensive chemotherapy, as well as comparisons to standard frontline therapies is warranted.
Molecular Characterization of Mesothelioma: Impact of Histologic Type and Site of Origin on Molecular Landscape
Authors: Dagogo-Jack Ibiayi , Madison Russell W. , Lennerz Jochen K. , Chen Kuei-Ting , Hopkins Julia F. , Schrock Alexa B. , Ritterhouse Lauren L. , Lester Ashley , Wharton Jr Keith A. , Mino-Kenudson Mari , Danziger Natalie , Hung Yin P. , Mata Douglas A. , Ross Jeffrey S. 
Published: June 2022

PURPOSE Mesothelioma is an aggressive malignancy with heterogeneous outcomes that are partly driven by the differential efficacy of existing therapies across histologic types and sites of origin. Large-scale molecular analysis of mesothelioma and its subtypes has the potential to inform future therapeutic strategies. MATERIALS AND METHODS We analyzed 1,294 mesotheliomas {980 pleural (malignant pleural mesothelioma [MPM]) and 314 peritoneal (malignant peritoneal mesothelioma [MPeM])} using next-generation sequencing, determined programmed death ligand-1 (PD-L1) expression and histology in a subset of cases, and assessed MTAP /CDKN2A copy-number status by fluorescence in situ hybridization and T-cell infiltration in an independent cohort. RESULTS The molecular landscape of MPM was characterized by inactivating alterations in CDKN2A (49%), BAP1 (44%), CDKN2B (42%), MTAP (34%), and NF2 (33%). Compared with epithelioid MPM, nonepithelioid (ie, biphasic and sarcomatoid) MPM had identical tumor mutational burden (median 1.25 mut/Mb, P = .63), more commonly expressed PD-L1 (74% v 51%, P = .02), and was more likely to harbor MTAP, CDKN2A, and CDKN2B copy loss ( P < .05). Fluorescence in situ hybridization confirmed that homozygous MTAP loss was enriched in nonepithelioid MPM. Relative to MPM, MPeM had comparable tumor mutational burden and PD-L1 expression. The molecular profile of MPeM was similar to MPM, with the distinction that PBRM1 alterations occurred at higher frequency (16% v 7%, P < .01). ALK rearrangements were only observed in MPeM. CONCLUSION Regardless of histology and location, the molecular landscape of mesothelioma primarily consists of inactivating alterations in tumor suppressor genes, with enrichment of certain alterations in distinct subsets (eg, MTAP loss in nonepithelioid tumors). Given the limited efficacy of current therapies for this disease, novel approaches targeting recurring alterations should be explored.
Metabolomic Changes Upon Conjugated Linoleic Acid Supplementation and Predictions of Body Composition Responsiveness
Authors: He Yafang , Xu Kun , Li Yunfeng , Chang Huan , Liao Xia , Yu Hang , Tian Tian , Li Chao , Shen Yuan , Wu Qian , Liu Xin , Shi Lin 
Published: June 2022

Abstract

Context
Conjugated linoleic acid (CLA) may optimize body composition, yet mechanisms underlining its benefits are not clear in humans.

Objective
We aimed to reveal the CLA-induced changes in the plasma metabolome associated with body composition improvement and the predictive performance of baseline metabolome on intervention responsiveness.

Methods
Plasma metabolome from overnight fasted samples at pre- and post-intervention of 65 participants in a 12-week randomized, placebo-controlled trial (3.2 g/day CLA vs 3.2 g/day sunflower oil) were analyzed using untargeted LC-MS metabolomics. Mixed linear model and machine learning were applied to assess differential metabolites between treatments, and to identify optimal panel (based on baseline conventional variables vs metabolites) predicting responders of CLA-derived body composition improvement (increased muscle variables or decreased adiposity variables) based on dual-energy x-ray absorptiometry.

Results
Compared with placebo, CLA altered 57 metabolites (P &lt; 0.10) enriched in lipids/lipid-like molecules including glycerophospholipids (n = 7), fatty acyls (n = 6), and sphingolipids (n = 3). CLA-upregulated cholic acid (or downregulated aminopyrrolnitrin) was inversely correlated with changes in muscle and adiposity variables. Inter-individual variability in response to CLA-derived body composition change. The areas under the curves of optimal metabolite panels were higher than those of optimal conventional panels in predicting favorable response of waist circumference (0.93 [0.82-1.00] vs 0.64 [0.43-0.85]), visceral adiposity index (0.95 [0.88-1.00] vs 0.58 [0.35-0.80]), total fat mass (0.94 [0.86-1.00] vs 0.69 [0.51-0.88]) and appendicular fat mass (0.97 [0.92-1.00] vs 0.73 [0.55-0.91]) upon CLA supplementation (all FDR P &lt; 0.05).

Conclusion
Post-intervention metabolite alterations were identified, involving in lipid/energy metabolism, associated with body composition changes. Baseline metabolite profiling enhanced the prediction accuracy for responsiveness of CLA-induced body composition benefits.
George Lamming: Reflections on Writing, Politics, and Caribbean Society
Authors: Farah Nuruddin , Bogues Anthony 
Published: June 2022

Abstract
This interview was conducted in September 2014 by the noted African novelist and writer Nuruddin Farah and the Caribbean intellectual historian and scholar Anthony Bogues. George Lamming, a seminal Caribbean novelist, writer, and thinker, is the author of six novels and a remarkable volume of essays, along with several other works. He belongs to a generation of Caribbean writers and intellectuals who carved out a space for Caribbean literature and thought in the twentieth century. In 2014 he was awarded the Anisfield-Wolf Book Award.
The Experience of Peril in Secular Criticism
Authors: Zartaloudis Thanos 
Published: June 2022

AbstractThis essay offers a reading of Stathis Gourgouris's The Perils of the One (2019). The peril of the One is primarily, Zartaloudis suggests, its poverty of experience. The impoverishment of experience is the purpose of transcendental foundations of the One, which, in Western traditions, is presupposed through a binary schema of power whereby potency is exhausted in actuality. This binary of power corresponds historically to the Christian Trinitarian oikonomia that predates the transcendental foundationalism of sovereign power/law and secular government. Hence, the age-old discourses that have been produced over many centuries over heteronomy and/or autonomy, across the theological, philosophical, juridical, and political spectrum, revolve around the same false paradox of how to form order in the world from a transcendental vantage point, without being able, by definition, to unfold it in the world. Determined to separate the false paradox (the “world” according to the One) from the true paradox (the cosmological abyss) within which it unfolds, humanity is thought to be destined to an inevitable state of war as if by nature. Secular criticism (in the manner of Edward Said and Gourgouris) as a tradition of thought offers an alternative to the polemic between traditions that are structured according to a false paradox (a world as the world) attempting to erase the unmappable cosmos. Such criticism, it is proposed, could become ever more creative and inviting if it reached out across traditions to compose an impassioned poietic thread that is premised on the negation neither of traditions nor of the irreparable cosmological abyss that marks our species.
Dorsal Root Entry Zone Lesioning for the Treatment of Pain After Brachial Plexus Avulsion Injury: 2-Dimensional Operative Video and Technical Report
Authors: Khalifeh Jawad M. , Lubelski Daniel , Ochuba Arinze , Belzberg Allan J. 
Published: June 2022

BACKGROUND:
Neuropathic pain after nerve root or plexus avulsion injury is disabling and often refractory to medical therapy. Dorsal root entry zone (DREZ) lesioning is a neurosurgical procedure that disrupts the pathological generation and transmission of nociceptive signaling through the selective lesioning of culprit neurons within the dorsal horn of the spinal cord.

OBJECTIVE:
To present a case report and describe the operative technique for cervical spinal cord DREZ lesioning using radiofrequency thermocoagulation.

METHODS:
We present the case of a 29-year-old man who experienced a traumatic right-sided brachial plexus avulsion injury. The patient experienced severe neuropathic pain in his distal right upper extremity. He underwent cervical spinal DREZ lesioning. Postoperatively, he reported immediate and total pain relief that was sustained on follow-up at 3 months. We describe the operative technique for DREZ lesioning, including preoperative considerations, patient position, incision, approach, exposure, microsurgical dissection, DREZ lesioning, fixation, and closure.

RESULTS:
The goal of DREZ lesioning is the selective destruction of nociceptive fibers within the lateral bundle of the dorsal rootlet and superficial layers of the dorsal horn gray matter, while preserving the medial inhibitory fibers. DREZ lesioning targets the putative pain generator and ascending pain pathways that mediate the characteristic neuropathic pain after avulsion injury. Neurological complications include worsening pain or motor and sensory deficits of the ipsilateral lower extremity.

CONCLUSION:
DREZ lesioning provides an effective and durable treatment for neuropathic pain after nerve root or plexus avulsion injury.
Rac1, the actin cytoskeleton and microtubules are key players in clathrin-independent endophilin-A3-mediated endocytosis
Authors: Tyckaert François , Zanin Natacha , Morsomme Pierre , Renard Henri-François 
Published: June 2022

ABSTRACT
Endocytic mechanisms actively regulate plasma membrane composition and sustain fundamental cellular functions. Recently, we identified a clathrin-independent endocytic (CIE) modality mediated by the BAR domain protein endophilin-A3 (endoA3, encoded by SH3GL3), which controls the cell surface homeostasis of the tumor marker CD166 (also known as ALCAM). Deciphering the molecular machinery of endoA3-dependent CIE should therefore contribute to a better understanding of its pathophysiological role, which remains so far unknown. Here, we investigate the role of actin, Rho GTPases and microtubules, which are major players in CIE processes, in this mechanism. We show that the actin cytoskeleton is dynamically associated with endoA3- and CD166-positive endocytic carriers, and that its perturbation strongly inhibits the process of CD166 uptake. We also reveal that the Rho GTPase Rac1, but not Cdc42, is a master regulator of this endocytic route. Finally, we provide evidence that microtubules and kinesin molecular motors are required to potentiate endoA3-dependent endocytosis. Of note, our study also highlights potential compensation phenomena between endoA3-dependent CIE and macropinocytosis. Altogether, our data deepen our understanding of this CIE modality and further differentiate it from other unconventional endocytic mechanisms.
This article has an associated First Person interview with the first author of the paper.
Physiological responses and adjustments of corals to strong seasonal temperature variations (20–28°C)
Authors: Sawall Yvonne , Nicosia Anna M. , McLaughlin Kathryn , Ito Maysa 
Published: June 2022

ABSTRACTTemperature is a key driver of metabolic rates. So far, we know little about potential physiological adjustments of subtropical corals to seasonal temperature changes (&gt;8°C) that substantially exceed temperature fluctuation experienced by their counterparts in the tropics. This study investigated the effect of temperature reductions on Montastraea cavernosa and Porites astreoides in Bermuda (32°N; sea surface temperature ∼19–29°C) over 5 weeks, applying the following treatments: (i) constant control temperature at 28°C, and (ii) temperature reduction (0.5°C day−1) followed by constant temperature (20 days; acclimatization period) at 24°C and (iii) at 20°C. Both species decreased photosynthesis and respiration during temperature reduction as expected, which continued to decrease during the acclimatization period, indicating adjustment to a low energy turnover rather than thermal compensation. Trajectories of physiological adjustments and level of thermal compensation, however, differed between species. Montastraea cavernosa zooxanthellae metrics showed a strong initial response to temperature reduction, followed by a return to close to control values during the acclimatization period, reflecting a high physiological flexibility and low thermal compensation. Porites astreoides zooxanthellae, in contrast, showed no initial response, but an increase in pigment concentration per zooxanthellae and similar photosynthesis rates at 24°C and 20°C at the end of the experiment, indicating low acute thermal sensitivity and the ability for thermal compensation at the lowest temperature. Respiration decreased more strongly than photosynthesis, leading to significant build-up of biomass in both species (energy reserves). Results are important in the light of potential poleward migration of corals and of potential latitudinal and species-specific differences in coral thermal tolerance.
Acupuncture and Dry Needling for Sports Performance and Recovery
Authors: Tang Chi-Tsai , Song Bo 
Published: June 2022

Abstract
Acupuncture and dry needling share many similarities in their proposed mechanisms of action and their sports medicine-related applications. Pain is the most common indication for these needling treatments, but there also are some limited studies on their use for ergogenic purposes. Needling can likely improve muscular strength and power, including increasing jump height, and it also can increase flexibility. In terms of sports recovery, acupuncture can not only be used for pain relief after injury, but also can help with routine recovery, such as in delayed onset muscle soreness. There are numerous case reports of acupuncture and dry needling being used to treat athletes for various diagnoses and conditions, however more high quality studies are needed in order to make more specific evidence-based recommendations. Given the high degree of safety and limited adverse events associated with needling treatments, it can likely be promoted in athletes.