bluuebunny/crossref_metadata_2025_split huggingface dataset:
Phytofabricated Nanoparticle Formulation for Cancer Treatment: A Comprehensive
Review
Authors: Verma Mahima , Fatima Shireen , Ansari Irfan Ahmad 
Published: April 2022

Abstract:
In recent times, nanotechnology has made significant advances in the field of cancer. The majority of
chemotherapeutic drugs do not selectively target cancer cells, and they might cause side effects and damage to
healthy cells, resulting in a variety of adverse effects. Having a thorough understanding of nanoparticles may improve
drug targeting and administration. The nano-engineering of pharmacological and natural compounds can improve
the diagnosis and treatment. Polymeric micelles, liposomes, and dendrimers are examples of innovative cancer
therapeutic nano-formulations. It has been demonstrated that quantum dots, nano-suspensions, and gold nanoparticles
can improve drug delivery. Nanomedicines may be delivered more effectively, focusing on cancerous cells instead
of healthy tissues, which minimizes undesirable side effects and drug resistance to chemotherapeutic agents. However,
limited water solubility, low stability, poor absorption, and quick metabolism limit their therapeutic effectiveness.
Nanotechnology has generated unique formulations to optimise the potential use of phytochemicals in anticancer
therapy. Nanocomposites can improve phytochemical solubility and bioavailability, extend their half-life in circulation,
and even transport phytochemicals to specific locations. The progress in using phytochemical-based nanoparticles
in cancer treatment is summarized in this paper.
Interactions Between Meropenem and Renal Drug Transporters
Authors: Dong Jing , Liu Yanhui , Li Longxuan , Ding Yunhe , Qian Jun , Jiao Zheng 
Published: April 2022

Background:
Meropenem is a carbapenem antibiotic and is commonly used with other antibiotics for the
treatment of bacterial infections. It is primarily eliminated renally by glomerular filtration and renal tubular secretion.

Objective:
This study aimed to evaluate the roles of renal uptake and efflux transporters in the excretion of meropenem
and potential drug interactions mediated by renal drug transporters.

Method:
Uptake and inhibition studies were conducted in human embryonic kidney 293 cells stably transfected
with organic anion transporter (OAT) 1, OAT3, multidrug and toxin extrusion protein (MATE) 1, and MATE2K, as
well as membrane vesicles containing breast cancer resistance-related protein (BCRP), multidrug resistance protein 1
(MDR1), and multidrug resistance-associated protein 2 (MRP2). Probenecid and piperacillin were used to assess
potential drug interactions with meropenem in rats.

Results:
We observed that meropenem was a low-affinity substrate of OAT1/3 and had a weak inhibitory effect on
OAT1/3 and MATE2K. BCRP, MDR1, MRP2, MATE1, and MATE2K could not mediate renal excretion of meropenem.
Moreover, meropenem was not an inhibitor of BCRP, MDR1, MRP2, or MATE1. Among five tested antibiotics,
moderate inhibition on OAT3-mediated meropenem uptake was observed for linezolid (IC50 value was 69.2
μM), weak inhibition was observed for piperacillin, benzylpenicillin, and tazobactam (IC50 values were 282.2, 308.0
and 668.1 μM, respectively), and no inhibition was observed for sulbactam. Although piperacillin had a relatively
high drug-drug interaction index (ratio of maximal unbound plasma concentration to IC50 was 1.42) in vitro, no
meaningful impact was reported on the pharmacokinetics of meropenem in rats.

Conclusion:
Our results indicated that clinically significant interactions between meropenem and these five antibiotics
are low.
β-lapachone: A Promising Anticancer Agent with a Unique NQO1 Specific
Apoptosis in Pancreatic Cancer
Authors: Qadir Muhammad Imran , Iqbal Muhammad Shahid , Khan Rimsha 
Published: April 2022

Abstract:
Cancer, one of the major health problems all over the world, requires more competent
drugs for clinical use. One recent possible chemotherapeutic drug under research is β-lapachone. β-
lapachone (1,2-naphthoquinone) has promising activity against those tumors showing raised levels of
Nicotinamide di-phosphate Quinone Oxidoreductases-1 (NQO1). NQO1 is found to be up-regulated
in pancreatic tumor cells, and thus β-lapachone could generate cytotoxicity in various cancers like
pancreatic tumors. β-lapachone harborage independent growth and clonogenic cell survival in agar.
The cell-killing effects of β-lapachone can be stopped by using dicumarol, an inhibitor of NAD(P)H
Quinone Oxidoreductases-1. In previously established pancreatic cancer xenografts in mice, β-
lapachone inhibited the tumor growth when given orally rather than when combined with cyclodextrin
to improve its bioavailability.
An Insight on the Potential of Manganese Porphyrins in Cancer Treatment
Authors: Chaurasia Pankaj Kumar , Bharati Shashi Lata , Singh Sunita , Yadava Sudha 
Published: April 2022

Abstract:
Porphyrin ligands are recognized for their exclusive tendency to form metal porphyrin complexes of pronounced value. Such metal porphyrin complexes display their inimitable roles as catalysts in various fields viz. conversion reactions, oxidation reactions, organic synthesis, pharmaceutical areas, biological and environmental fields, and many more. Out of different metal porphyrins; manganese porphyrins are one of the appreciated metal porphyrins due to their prodigious catalytic performance and potential in cancer treatment. In this perspective, the proficient participation of manganese porphyrins in the treatment of cancer along with operative discussions on molecular pathways have been briefly but effectively assessed based on the recent scientific literatures available.
Association between ABO Blood Groups and Type 2 Diabetes Mellitus:
A Meta-Analysis
Authors: Cano Earl Adriane , Esguerra Marion Agatha , Batausa Ariane Michaela , Baluyut Jessica Rose , Cadiz Ria , Docto Hewmy Franci , Encabo Jose Ramir , Gomez Reena Mae , Sadang Maria Gina 
Published: April 2022

Background:
The role of the ABO blood group goes beyond immunohematology as
there is accumulating evidence on its association with type 2 diabetes mellitus. However, findings
regarding the relation have been contradictory and there is a need to determine the validity of
claims.

Objective:
Evaluate the susceptibility of the ABO blood groups to type 2 diabetes mellitus.

Method:
The research design is a meta-analysis. An extensive search was done in PubMed, ScienceDirect,
ResearchGate, and Google Scholar. Heterogeneity was determined through Cochran’s
Q test and I2 index. Random-effects model was used to measure the risk ratio and confidence intervals.
Evaluation of publication bias was done using the funnel plot method; further supported by
Egger’s linear regression test and Begg’s test.

Results:
The relative susceptibility of ABO blood groups to type 2 diabetes mellitus differs for
blood type A (Relative risk [RR] = 1.05, 95% CI, 0.93 to 1.18), blood type B (RR = 1.03, 95% CI,
0.91 to 1.18), blood type AB (RR = 1.25, 95% CI, 0.78 to 1.99), and blood type O (RR = 1.11,
95% CI, 0.82 to 1.48). The highest risk of acquiring the disease was seen in type AB individuals,
while the lowest risk was seen in type B individuals.

Conclusion:
A significant association was found between ABO blood groups and type 2 diabetes
mellitus. ABO phenotype can therefore be considered a possible risk factor or potential genetic determinant
of the disease, which can be used to improve diagnosis and treatment.
Detection of COVID-19 Incidentally in 68Ga-PSMA PET/CT for Restaging
of Prostate Cancer
Authors: Seven Bedri , Okudan Berna , Ural Betül , Çapraz Mustafa 
Published: April 2022

Background:
A series of pneumonia cases with clinical presentations of viral pneumonia
secondary to new coronavirus and subsequent global transmission arose in Wuhan, Hubei, China, in
December 2019. Several cases of coronavirus disease 2019 (COVID-19) have been described incidentally
in positron emission tomography-computed tomography (PET/CT) with 18Ffluorodeoxyglucose
(FDG) as a result of the pandemic. Herein, we describe the findings of a patient
with unknown COVID-19 in PET/CT with the other radiopharmaceutical, 68Ga-labeled prostatespecific
membrane antigen (68Ga-PSMA).

Case Report:
A 69-year-old man had previously undergone radical prostatectomy for adenocarcinoma.
68Ga-PSMA PET/CT imaging was performed due to biochemical recurrence. 68Ga-PSMA uptake in the
prostate bed suggestive of local recurrence was detected in PET/CT images. Also, bilateral groundglass
opacities with slightly increased 68Ga-PSMA uptake were seen in the lungs, suspected of
COVID-19. A reverse transcription-polymerase chain reaction test has confirmed the infection.

Conclusion:
Even in asymptomatic patients, nuclear medicine departments must be aware of the possibility
of COVID-19, take appropriate post-exposure procedures, and protect employees and other
patients.
Analysis of Shenhuang Capsule using HPLC: Method Development, Validation, and Application
Authors: Si Yuankai , Huang Yuanqiong , Chen Meijuan , Wu Zhigui , Li Gu , Li Hua , Ge Pei , Liu Huan , Zhang Wenqiang , Xu Yanli 
Published: April 2022

Objective:
Shenhuang (SH) capsule is a traditional Chinese medicine compound preparation
containing rhubarb, coptis, scutellaria, salvia and Pueraria, used for diabetic nephropathy
studied by our research group in the early stage. This study aims to develop the method of qualitative
identification and content determination of the main active ingredients of SH capsules so as
to establish the quality standard.

Methods:
HPLC method was used to determine the contents of rhein, Pueraria, and tanshinone in
SH capsules. The determination method of SH capsules was established through the determination
of specificity, regression equation, precision, repeatability, and recovery. The general quality
standard of SH capsules was established by measuring water content, disintegration time, and microorganism.
The contents of rhein, puerarin, and tanshinone IIA in SH capsules were determined
by HPLC.

Results:
The precision was 1.10–3.00% and the reproducibility and recovery rates were 95.0–
105.7%. The moisture determination, disintegration time, and microorganism examination of SH
capsule were all in line with the standard.

Conclusion:
The stable, feasible, simple, and reliable content determination method was established
through the content determination of SH capsules and the general quality standard test.
Development and Validation of an ELISA to Evaluate Neutralizing Equine Anti Shiga Toxin Antibodies in Preclinical Studies
Authors: Santiago Gonzalo , Yanina Hiriart , Muñoz Luciana , Rey Florencia , Hein Gustavo , Sanguineti Santiago , Zylverman Vanesa , Ortega Hugo H. , Marelli Belkis E. 
Published: April 2022

Background:Hemolytic uremic syndrome associated with Shiga-toxin produced by Escherichia coli is a serious worldwide foodborne disease. Nowadays, no treatment is available, only supportive care can be provided, and 50 % of the patients require a period of dialysis. Recently, a therapy based on Neutralizing Equine Anti Shiga Toxin (NEAST) antibodies has been developed. NEAST is composed of F(ab’)2 fragments from equine immunoglobulins.Objective:The purpose of this study was to develop an ELISA to measure serum concentrations of NEAST in mice and rabbits, and to validate it according to international recommendations. The validated method was further used to analyze the NEAST PK during preclinical studies.Methods:A sandwich ELISA was developed, the performance of the calibration curve was assessed, and it was validated based on the parameters as accuracy, precision, specificity, selectivity, stability of the analyte, and dilutional linearity.Results:This immunoassay was specific, sensitive, accurate and precise in a dynamic range from 7.81 to 500 ng/mL and from 15.63 to 500 ng/mL for mice and rabbits, respectively. This method was successfully applied to PK studies of NEAST after intravenous administration.conclusion:The results obtained are expected for a robust ELISA used for macromolecule analysis. Since NEAST is an equine F(ab′)2, this immunoassay would serve for the evaluation of the PK profile of any biological product based on molecules with similar characteristics. This immunoassay may be useful for current and future preclinical trials conducted for registration purposes.
Development, Testing, and Implementation of the Belgian Patient Reported Experience Measure for Pancreatic Cancer Care (PREPARE) Project: Protocol for a Multi-Method Research Project
Authors: Moens Katrien , Peeters Marc , Van den Bulcke Marc , Leys Mark , Horlait Melissa 
Published: April 2022

Background
Patients with pancreatic cancer do not feel involved in the development of their treatment and care plans. In Belgium, these plans are decided on during multidisciplinary team meetings. However, limited time is spent on the discussion of the preferences of the patient during these meetings. This research project aims to develop a patient-reported experience measure (PREM) for pancreatic cancer and assess if its use can support collaborative treatment decision-making.

Objective
This paper aims to outline the protocol for a multi-method research project to improve person-centered pancreatic cancer care in Belgium. Three subobjectives are pursued: (1) to develop a PREM to assess the experiences of care-related aspects in pancreatic cancer care, (2) to validate the PREM, and (3) to develop and evaluate an educational intervention to support the use of the PREM’s results.

Methods
For the development of the PREM, an exploratory mixed methods study design will be used. The study will start with a survey followed by a telephone interview involving patients with pancreatic cancer and digestive oncology health care professionals. Study two is the testing of the content and construct validity of the PREM. Study three involves the implementation study according to the Medical Research Council framework of a complex intervention introducing the PREM in practice. The effectiveness of the intervention will be investigated using a pragmatic randomized controlled trial study design.

Results
The protocol presents the entire structure of the research project. Ethics approval to conduct the exploratory mixed methods study (objective 1) has been obtained, and recruitment has started since January 2022.

Conclusions
The poor prognosis of patients with pancreatic cancer should not be considered a hurdle to not study this patient population group. Involving patients in the research and decision-making processes early on is key. This project aims to realize a scientifically sound research process providing research outputs that can easily and timely be implemented in the care trajectory of patients with pancreatic cancer. This research project will also lead to recommendations on how to involve patients with pancreatic cancer and how the methodology of this research project can be translated to other patient groups.

International Registered Report Identifier (IRRID)
PRR1-10.2196/29004
Using Smartphone Sensor Paradata and Personalized Machine Learning Models to Infer Participants’ Well-being: Ecological Momentary Assessment
Authors: Hart Alexander , Reis Dorota , Prestele Elisabeth , Jacobson Nicholas C 
Published: April 2022

BackgroundSensors embedded in smartphones allow for the passive momentary quantification of people’s states in the context of their daily lives in real time. Such data could be useful for alleviating the burden of ecological momentary assessments and increasing utility in clinical assessments. Despite existing research on using passive sensor data to assess participants’ moment-to-moment states and activity levels, only limited research has investigated temporally linking sensor assessment and self-reported assessment to further integrate the 2 methodologies.ObjectiveWe investigated whether sparse movement-related sensor data can be used to train machine learning models that are able to infer states of individuals’ work-related rumination, fatigue, mood, arousal, life engagement, and sleep quality. Sensor data were only collected while the participants filled out the questionnaires on their smartphones.MethodsWe trained personalized machine learning models on data from employees (N=158) who participated in a 3-week ecological momentary assessment study.ResultsThe results suggested that passive smartphone sensor data paired with personalized machine learning models can be used to infer individuals’ self-reported states at later measurement occasions. The mean R2 was approximately 0.31 (SD 0.29), and more than half of the participants (119/158, 75.3%) had an R2 of ≥0.18. Accuracy was only slightly attenuated compared with earlier studies and ranged from 38.41% to 51.38%.ConclusionsPersonalized machine learning models and temporally linked passive sensing data have the capability to infer a sizable proportion of variance in individuals’ daily self-reported states. Further research is needed to investigate factors that affect the accuracy and reliability of the inference.
Training Resources Targeting Social Media Skills to Inform Rehabilitation for People Who Have an Acquired Brain Injury: Scoping Review
Authors: Brunner Melissa , Rietdijk Rachael , Togher Leanne 
Published: April 2022

Background
In 2020 and 2021, people increasingly used the internet to connect socially and professionally. However, people with an acquired brain injury (ABI) experience challenges in using social media, and rehabilitation professionals have reported feeling underprepared to support them in its use. To date, no review of social media skills training to inform ABI rehabilitation has been conducted.

Objective
This scoping review aimed to examine research on interventions addressing social media skills and safety, with a focus on people living with health conditions; free web-based resources for the general public on social media skills training; and currently available online support groups for people with ABI.

Methods
An integrative scoping review was conducted, with a systematic search strategy applied in March and November 2020 across OvidSP (MEDLINE, AMED, PsycINFO, and Embase), Scopus, Web of Science, CINAHL, Google Scholar, Google, and Facebook. The data collected were critically appraised and synthesized to describe the key content and features of social media training resources.

Results
This review identified 47 peer-reviewed academic articles, 48 social media training websites, and 120 online support groups for people with ABI. A key recommendation was interactive training with practical components addressing cybersafety, how to use platforms, and how to connect with others. However, no social media training resources that were relevant and accessible for people with ABI were identified.

Conclusions
Training resources to support people with ABI in safely using social media are limited. The key content to be addressed and the features to be incorporated into web-based social media training were determined, including the need for interactive training that is co-designed and safe and incorporates practical components that support people with ABI. These findings can be used to inform the development of web-based evidence-based support for people with ABI who may be vulnerable when participating in social media.
A Novel Score for mHealth Apps to Predict and Prevent Mortality: Further Validation and Adaptation to the US Population Using the US National Health and Nutrition Examination Survey Data Set
Authors: Elnakib Shatha , Vecino-Ortiz Andres I , Gibson Dustin G , Agarwal Smisha , Trujillo Antonio J , Zhu Yifan , Labrique Alain B 
Published: April 2022

Background
The C-Score, which is an individual health score, is based on a predictive model validated in the UK and US populations. It was designed to serve as an individualized point-in-time health assessment tool that could be integrated into clinical counseling or consumer-facing digital health tools to encourage lifestyle modifications that reduce the risk of premature death.

Objective
Our study aimed to conduct an external validation of the C-Score in the US population and expand the original score to improve its predictive capabilities in the US population. The C-Score is intended for mobile health apps on wearable devices.

Methods
We conducted a literature review to identify relevant variables that were missing in the original C-Score. Subsequently, we used data from the 2005 to 2014 US National Health and Nutrition Examination Survey (NHANES; N=21,015) to test the capacity of the model to predict all-cause mortality. We used NHANES III data from 1988 to 1994 (N=1440) to conduct an external validation of the test. Only participants with complete data were included in this study. Discrimination and calibration tests were conducted to assess the operational characteristics of the adapted C-Score from receiver operating curves and a design-based goodness-of-fit test.

Results
Higher C-Scores were associated with reduced odds of all-cause mortality (odds ratio 0.96, P<.001). We found a good fit of the C-Score for all-cause mortality with an area under the curve (AUC) of 0.72. Among participants aged between 40 and 69 years, C-Score models had a good fit for all-cause mortality and an AUC >0.72. A sensitivity analysis using NHANES III data (1988-1994) was performed, yielding similar results. The inclusion of sociodemographic and clinical variables in the basic C-Score increased the AUCs from 0.72 (95% CI 0.71-0.73) to 0.87 (95% CI 0.85-0.88).

Conclusions
Our study shows that this digital biomarker, the C-Score, has good capabilities to predict all-cause mortality in the general US population. An expanded health score can predict 87% of the mortality in the US population. This model can be used as an instrument to assess individual mortality risk and as a counseling tool to motivate behavior changes and lifestyle modifications.
Evaluation of land suitability for the development of Hiyung cayenne pepper in Hiyung Village, Tapin Tengah District, South Kalimantan
Authors: Taher Ratna , Syarbini Muhammad , Wilda Kamiliah 
Published: April 2022

Hiyung Village is one of the centers of agricultural production, especially cayenne pepper. The advantage of Hiyung cayenne pepper is its spiciness which has capcaisin compound of 94.5 thousand ppm. It is 17 times spicier than cayenne pepper in general. The success of agricultural cultivation is greatly influenced by the land suitability. Furthermore, soil and environmental conditions affect plant growth and development. This study aims to analyze the soil properties and land characteristics to evaluate their suitability for the development of Hiyung cayenne pepper. This study is a descriptive research, carried out using a land suitability evaluation survey method to obtain data on land characteristics and current land management. Soil samples were taken from five locations, each about 1 km apart. Three sample points were taken at a depth of 0 cm to 20 cm in each location. Observation were made on effective depth, slope, surface rocks, rock outcrops, flood hazard, coarse material in soil cross section, erosion hazard, temperature, mean annual precipitation, length of the dry season, and current land management. The results showed that the actual land suitability is included in the S3 (marginally suitable) with limiting factors of temperature, water availability (rainfall), and nutrient retention (pH and base saturation). Potential land suitability is still included in S3 class (marginally suitable) because the only limiting factors that may be improved are soil pH and base saturation.