bluuebunny/crossref_metadata_2025_split huggingface dataset:
User behavior analysis based on edge evolutionary game model in social network
Authors: Chen Jing , Yang Hongbo , Wei Nana , Liu Mingxin 
Published: July 2022

AbstractThe application of evolutionary game method to study user behavior in social networks is a current hot issue. Most of the current evolutionary game models are proposed based on the game between nodes, which cannot accurately describe the diverse behaviors of users, and ignores the influence of network dynamics on evolutionary game. In order to solve the above problems, an edge evolution game (EEG) model is proposed in this paper. Firstly, the edge game model combines the pairwise interaction mode with the prisoner’s dilemma payoff matrix to calculate the user income. Secondly, on the basis of strategy update, the disconnect–reconnect mechanism is proposed to promote the updating of user relationship. In this mechanism, nodes perform the disconnect–reconnect based on the incomes: the betrayal neighbor with the lowest incomes is disconnected, and the neighbor of the disconnected neighbor with the highest incomes is reconnected. Finally, three kinds of networks are selected for experimental verification. The experimental results show that the cooperation clusters are formed in all three kinds of networks, which greatly promote the cooperation evolution among users.
The interaction of different abiotic conditions on the value of the component traits of the technological yield of sugar beet
Authors: Bocianowski Jan , Jakubowska Magdalena , Kowalska Jolanta 
Published: July 2022

AbstractThe aim of this study was to analyse the effects of different date of insecticidal treatment against Noctuinae caterpillars on the technological yield from sugar beet using the additive main effect and multiplicative interaction (AMMI) model. The AMMI model is one of the most widely used statistical tools in the analysis of multiple-environment trials. The results of the analysis of the dependence of the components of the sugar beet yield, carried out separately in individual years (2011–2018) of the experiment, indicate a significant and directly proportional impact of the root mass on the technological yield of sugar in all years. The average sugar content per years also varied from 16.22% (2014) to 19.68% (2015). Potassium molasses from the base of the tested protective treatments varied from 27.27 to 61.43 mmol kg−1. The average sodium molasses per years also varied from 1.196 mmol kg−1 (2015) to 6.692 mmol kg−1 (2018). α-amine-nitrogen of the tested protective treatments varied from 6.03 (for phenological criterion in 2011) to 37.95 mmol kg−1 (for intervention criterion in 2018). Technological yield of sugar beet tested protective treatments varied from 171.4 (for phenological criterion in 2015) to 360.0 t ha−1 (for soil spraying of plants—in 2012) throughout the 8 years, with an average of 280.47 t ha−1. The use of the AMMI model to estimate the interaction of conducted insecticidal treatments based on environmental conditions showed the additivity of the effects of the applied treatments on the effectiveness of the obtained quality features of the technological yield of sugar beet.
“The hysteria of a little flu”: effects of COVID-19 on HEIs in Brazil
Authors: Bento Katucha 
Published: July 2022

AbstractThis essay will look at the key challenges public Higher Education Institutions (HEIs) faced in Brazil during the COVID-19 lockdown. The pandemic led universities to close their campuses and adopt an online interface for academic activities. However, many of these institutions do not have the technological infrastructure for such, nor did the staff and students who suffered further social exclusions. The president of Brazil referred to the pandemic as a “little flu” and later on responded to measures adopting the lockdown as a “hysteric” act that “will lead to an economic crash”. Considering the lack of support from the government and the process of dismantling resources for public HE since the beginning of the new presidency elected in 2018, the COVID-19 lockdown quickly revealed the institutional racism, elitism and ableism evident in this administration’s agenda. The consequence of the agenda is the cuts on research funds and lack of infrastructure to provide online classes, as examples of the severe policies that promote the erasure of marginalised groups. Such policies follow Sylvia Wynter’s “Argument”, revealing a code of symbolic life and death of how human order organises itself through the coloniality of power/being. In order to show how such symbolic code is engraved in the Brazilian educational system, this study explores narratives of staff and students from three universities per region of Brazil to identify how the colonial legacies are correlated with postulates of power in the Brazilian HEIs setting during the pandemic. The paper discusses the challenges experienced while keeping the HE sector active during a pandemic that the government has belittled. The conclusions advocate for organised strategies at the union and social movements level to dismantle the colonial occupation put in place in the foundation of the HEIs and reinforced by the current necropolitical administration.
Theorising pedagogical dimensions of higher education leadership—a non-affirmative approach
Authors: Elo Janne , Uljens Michael 
Published: July 2022

Abstract Today, multilevel analytics on educational governance, management, and leadership are common in educational leadership research, drawing on a variety of approaches and academic disciplines. This article develops a threefold critique of the state of the art. First, this article argues that research on higher education leadership often represents an unreflected position regarding the societal role of higher education—decontextualising leadership from external practices and disregarding its internal object. Second, the approaches applied in leadership as a multilevel phenomenon can be problematic. On one end of the spectrum, we find particularist approaches focusing on individual levels representing disparate and often incompatible theoretical perspectives. As these positions rarely communicate, they have difficulties producing a coherent representation of higher education leadership. Universalist approaches, in turn, study leadership on several levels but offer identical conceptual tools for any societal practice, thereby losing the sensibility of the societal, cultural, and economic tasks of higher-education institutions, and for their specific character as institutions for research and teaching. Thirdly, research on educational leadership mostly fail to provide adequate theory of pedagogical interaction and influence. This is a twofold challenge. On the one hand, research lacks a theory of the object of educational leadership, namely teaching and studying. On the other, although research often defines leadership as a process of influence aimed at supporting learning, it lacks a theory able to explain what constitutes this influence. This article elaborates the possibilities for non-affirmative theory of education to provide a theory and language to overcome these challenges.
Investigation of TLR4 Antagonists for Prevention of Intestinal Inflammation
Authors: Tam Janine S. Y. , Coller Janet K. , Prestidge Clive A. , Bowen Joanne M. 
Published: July 2022

AbstractActivation of toll-like receptor 4 (TLR4) has been shown to be a major influence on the inflammatory signalling pathways in intestinal mucositis (IM), as demonstrated by TLR4 knock-out mice. Pharmacological TLR4 inhibition has thus been postulated as a potential new therapeutic approach for the treatment of IM but specific TLR4 inhibitors have yet to be investigated. As such, we aimed to determine whether direct TLR4 antagonism prevents inflammation in pre-clinical experimental models of IM. The non-competitive and competitive TLR4 inhibitors, TAK-242 (10 µM) and IAXO-102 (10 µM), respectively, or vehicle were added to human T84, HT-29, and U937 cell lines and mouse colonic explants 1 h before the addition of lipopolysaccharide (LPS) (in vitro: 100 µg/mL; ex vivo: 10 µg/mL), SN-38 (in vitro: 1 µM or 1 nM; ex vivo: 2 µM), and/or tumour necrosis factor-alpha (TNF-α) (5 µg/mL). Supernatant was collected for human IL-8 and mouse IL-6 enzyme-linked immunosorbent assays (ELISAs), as a measure of inflammatory signalling. Cell viability was measured using XTT assays. Explant tissue was used in histopathological and RT-PCR analysis for genes of interest: TLR4, MD2, CD14, MyD88, IL-6, IL-6R, CXCL2, CXCR1, CXCR2. SN-38 increased cytostasis compared to vehicle (P < 0.0001). However, this was not prevented by either antagonist (P > 0.05) in any of the 3 cell lines. Quantitative histological assessment scores showed no differences between vehicle and treatment groups (P > 0.05). There were no differences in in vitro IL-8 (P > 0.05, in all 3 cells lines) and ex vivo IL-6 (P > 0.05) concentrations between vehicle and treatment groups. Transcript expression of all genes was similar across vehicle and treatment groups (P > 0.05). TLR4 antagonism using specific inhibitors TAK-242 and IAXO-102 was not effective at blocking IM in these pre-clinical models of mucositis. This work indicates that specific epithelial inhibition of TLR4 with these compounds is insufficient to manage mucositis-related inflammation. Rather, TLR4 signalling through immune cells may be a more important target to prevent IM.
Barriers to Seeking Psychotherapy for Mental Health Problems in Adolescents: a mixed method study
Authors: Pfeiffer Simone , In-Albon Tina 
Published: July 2022

AbstractGiven the large discrepancy between prevalence rates of mental disorders in adolescents and actual treatment rates, there is a need to understand what prevents this age group from seeking psychotherapy. We assessed the barriers to seeking psychotherapy in this age group, including their attitudes toward people with a mental disorder, using a convergent parallel mixed-methods design. Participants were 288 adolescents aged 12–21 years (M = 16.8 years, SD = 2.3; 37% identified as male, 63% as female, and 0% as nonbinary). Qualitative data were obtained with open-ended questions on barriers to initiating psychotherapy and attitudes toward people with a mental disorder. Barriers to seeking psychotherapy and information about psychotherapy were assessed with a questionnaire using a quantitative design. The qualitative assessment revealed as the main barriers fear of a negative interaction with a psychotherapist, fear of being confronted with their own emotions, self-stigma, and fear of public stigma. Further, lack of accessibility, lack of trust in the therapist, a desire for social distance from, and a negative attitude toward people with a mental disorder were associated with a decreased intention to initiate psychotherapy. Previous positive experience with a psychotherapist was a facilitator of seeking psychotherapy. We found gender differences, with higher desire for social distance and higher optimism bias scores as well as poorer mental health knowledge for participants identifying as male. Integrating results from both approaches results in further information for the improvement of prevention programs and interventions to lower barriers to seeking psychotherapy. Gender differences indicate a need for gender-role-specific interventions.
Modeling glass transition temperatures of epoxy systems: a machine learning study
Authors: Meier Sven , Albuquerque Rodrigo Q. , Demleitner Martin , Ruckdäschel Holger 
Published: July 2022

AbstractThe use of machine learning (ML) models to screen new materials is becoming increasingly common as they accelerate material discovery and increase sustainability. In this work, the chemical structures of 16 epoxy resins and 19 curing agents were used to build an ML ensemble model to predict the glass transition ($$T_g$$Tg) of 94 experimentally known thermosets. More than 1400 molecular descriptors were calculated for each molecule, of which 119 were chosen based on feature selection performed by principal component analysis. The quality of the trained model was evaluated using leave-one-out cross-validation, which yielded a mean absolute error of 16.15$$^{\circ }$$∘C and an$$R^2$$R2value of 0.86. The trained model was also used to predict$$T_g$$Tgfor 4 randomly selected resin/hardener combinations for which no experimental data were available. The same combinations were then prepared and measured in the laboratory to further validate the ML model. Excellent agreement was found between experimental and predicted$$T_g$$Tgvalues. The current ML model was created using only theoretical features, but could be further improved by adding experimental or quantum mechanical properties of the individual molecules as well as experimental processing parameters. The results presented here contribute to improving sustainability and accelerating the discovery of novel materials with desired target properties.Graphical Abstract
HEM1 Actin Immunodysregulatory Disorder: Genotypes, Phenotypes, and Future Directions
Authors: Cook Sarah , Lenardo Michael J. , Freeman Alexandra F. 
Published: July 2022

AbstractCells of the innate and adaptive immune systems depend on proper actin dynamics to control cell behavior for effective immune responses. Dysregulated actin networks are known to play a pathogenic role in an increasing number of inborn errors of immunity. The WAVE regulatory complex (WRC) mediates branched actin polymerization, a process required for key cellular functions including migration, phagocytosis, vesicular transport, and immune synapse formation. Recent reports of pathogenic variants in NCKAP1L, a hematopoietically restricted gene encoding the HEM1 protein component of the WRC, defined a novel disease involving recurrent bacterial and viral infections, autoimmunity, and excessive inflammation (OMIM 141180). This review summarizes the diverse clinical presentations and immunological phenotypes observed in HEM1-deficient patients. In addition, we integrate the pathophysiological mechanisms described in current literature and highlight the outstanding questions for diagnosis and management of the HEM1 actin immunodysregulatory disorder.
The Role of Self-Control in Predicting Intimate Partner Violence Specialization in an Australian Community Sample
Authors: Wolbers Heather , Ackerman Jeffrey , Ready Justin 
Published: July 2022

Abstract

Purpose
This study builds on knowledge of intimate partner violence (IPV) perpetration by examining theoretically important aspects of this crime within an Australian community sample. More specifically, the current study examines the relationship between IPV offenders’ levels of self-control and offense specialization and determines whether this relationship differs by gender.

Method
An online survey advertised on social media yielded an analysis sample of 155 females and 170 males. Self-control was measured using the Brief Self-Control scale and specialization was measured with the Offense Specialization Coefficient (OSC) and a multilevel item response theory measurement approach.

Results
Findings indicate that IPV offenders with low levels of self-control are more versatile in their offending and that this relationship was more evident and pronounced for females.

Conclusions
Findings are mostly supportive of Gottfredson and Hirschi’s General Theory of Crime and highlight important differences within IPV offender populations that should be considered when designing targeted prevention and intervention methods.
An Economic Model of Gambling Behaviour: A Two-Stage Approach
Authors: Cameron Lachlan , Ride Jemimah , Devlin Nancy 
Published: July 2022

AbstractGambling can cause significant harms and these can result in a net negative utility from participation, although lower levels of participation have potential benefits and can yield positive net utility. It is therefore important to understand and distinguish between these two stages of gambling behaviour. Currently, economic models have had limited focus on explaining why someone would gamble despite it yielding a negative utility. Here, we present a two-stage model, motivated by empirical literature and intuitive assumptions, that improves on existing economic models by distinguishing between the likelihood of gambling participation and of gambling that yields a negative utility. The model’s predictions are empirically testable, consistent with existing literature, and add new insights. The model’s ability to distinguish between the two stages helps to inform interventions that aim to reduce the prevalence of gambling-related harm while avoiding the need for restrictive approaches that aim to eliminate gambling altogether.
Synthesis, 99mTc-labeling, in-vivo study and in-silico investigation of 6-amino-5-[(bis-(2-hydroxy-ethyl)-amino]methyl]2-methyl pyrimidin-4-ol as a potential probe for tumor targeting
Authors: Essa Basma M. , Abd-Allah Walaa H. , Sakr Tamer M. 
Published: July 2022

AbstractThis study aimed to synthesize a new pyrimidine derivative with a good synthesis yield of 87% to act as a new cancer marker after radiolabeling with Tc-99m in a high radiochemical yield of 92.3%. In-vivo study in tumor-bearing Swiss albino mice model revealed promising data with high uptake in cancer. Docking study showed good binding interactions of the radiosynthesized complex at the binding site. In conclusion, this novel complex could be a potential probe for cancer targeting.
How to combine multiple identities and gaining stakeholders legitimacy in hybrid organizations? An organizational design response
Authors: Zollo Lamberto , Pellegrini Massimiliano M. , Faldetta Gugliemo , Rialti Riccardo 
Published: July 2022

AbstractHybrid organizations’ success should effectively fulfill both beneficiaries’ and customers’ needs, requirements, and expectations, being embedded in the conflicting—and often incompatible—institutional logics of social mission and commercial activities. Despite the increasing attention to such a phenomenon in the business research literature, still little is known regarding how hybrid organizational structures may facilitate or hinder the co-existence of such conflicting institutional logics. Relying on an inductive comparative case study realized on 9 socially entrepreneurial NPOs—which represent significant examples of socially imprinted organizations involved in commercial activities (hybrid)—operating in the Italian socio-healthcare sector, two main concerns have arisen as particularly influenced by organizational decisions, namely (a) effectively combining multiple identities within the organization and (b) gaining legitimacy from stakeholders. Results show that a coherent identity for a hybrid organization seems to be facilitated by an integrated structure, i.e., social programs and commercial activities run in a unique organization. On the contrary, a compartmentalized organizational structure creates two separate legal entities of a social or commercial nature only and is more crucial in gaining external legitimacy. Finally, some hybrids seem to mimic both features of these organizational structures, tackling both necessities. Thus, this study provides comparisons and practice-oriented implications to implement such organizational changes and explores the complex universe of hybrid organizational design by simultaneously comparing different organizational structures.
Mono- and di-acylated imidazolidine-2-thione derivatives: synthesis, cytotoxicity evaluation and computational studies
Authors: Scarsi Anna , Ponassi Marco , Brullo Chiara , Rosano Camillo , Spallarossa Andrea 
Published: July 2022

AbstractImidazolidine-2-thione substructure represents a pharmaceutically attractive scaffold, being included in different antimicrobial, anticancer and pesticide agents. To further evaluate the pharmaceutical potential of this chemical moiety, imidazolidine-2-thione was reacted with atypical Vilsmeier adducts, obtained by the condensation between dimethylacetamide and various acyl chlorides endowed with different electronic and steric properties. The formation of mono-acylated or di-acylated thiourea derivatives emerged to be affected by the nature of the considered acyl chloride reagent. Computational semi-empirical simulations were carried out to rationalize the relevant factor influencing the outcome of the reaction. As acylthioureas are pharmacologically relevant compounds, the chemical versatility of mono-acylated derivatives were evaluated by reacting benzoyl imidazolidin-2-thione with acyl chlorides. A small library of asymmetric di-acylthioureas was prepared and the obtained derivatives did not show any cytotoxicity on SKOV-3 and MCF-7 cancer cell lines. Additionally, in silico studies predicted good pharmacokinetics properties and promising drug-like characteristics for mono- and di-acylated thioureas. These considerations further support the value of the prepared compounds as interesting non-cytotoxic chemical scaffold useful in the medicinal chemistry field.
Graphical abstract
Cardiovascular health and mortality in Cushing’s disease
Authors: Coulden Amy , Hamblin Ross , Wass John , Karavitaki Niki 
Published: July 2022

AbstractExposure to cortisol excess in Cushing’s disease (CD) results in increased cardiovascular morbidity and reduces survival, with cardiovascular disease being a leading cause of death. At diagnosis, a significant number of patients have adverse cardiovascular profiles (e.g., obesity, diabetes or impaired glucose tolerance, dyslipidemia, hypertension, cardiac abnormalities and vascular disease). Remission of hypercortisolemia reduces but does not completely eliminate the cardiovascular complications; hazard ratios for myocardial infarction and stroke are high during long-term monitoring, highlighting the long-lasting effects of hypercortisolism and the importance of the timely diagnosis and successful management of this condition. Data on mortality of patients in remission are not consistent but in a multicenter study, an increased all-cause and circulatory mortality in patients with CD in remission for at least 10 years has been demonstrated. Cardiovascular morbidity requires particular focus and effective management during the care of patients with CD, from their presentation until long-term follow up.
The Variables that Predict Science Undergraduates’ Timely Degree Completion: a Conceptual Model
Authors: Rayner Gerry , Papakonstantinou Theo 
Published: July 2022

Abstract
Science undergraduates’ timely degree completion (TDC) has become increasingly important for students themselves, universities, and society, due to issues such as cost, efficiency, and productivity, respectively. This study investigated the potential effect of several variables on TDC of Bachelor of Science (BSc) students at an Australian research-intensive university. Results showed that two time-dependent variables (TDVs)—gender and Australian Tertiary Admission Rank (ATAR)—predicted TDC. Two time-independent variables (TIVs)—the number of discipline majors and specific year level academic achievement—also predicted TDC. Students who completed on time had a significantly higher mean weighted average mark (WAM) than non-TDC students, for each year of study, and more females than males completed their BSc in a timely manner. The primary determinants of TDC were gender, number of discipline majors, and WAM at each of years 2 and 3. Our conceptual model of TDC indicates the predictive interrelationships among these TIVs and TDVs. A more informed understanding of the study’s outcomes among university stakeholders has considerable potential to enhance the engagement, scaffolding, achievement, and TDC of science undergraduates.