bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Comparative Research of Two English Translations of the Chapter “Comprehensive Discourse on Phenomena Corresponding to Yin and Yang” in Huangdi's Internal Classic
Authors: Zhou Zhi-Wei , Li Yan-Qing , Li Hai-Ying 
Published: July 2022

Abstract
Culture-loaded words refer to words with specific cultural connotations that can express an abstract or a specific concept, which may be related to religious beliefs or social customs, but do not exist in other languages and cultures. Therefore, culture-loaded words bring some difficulties to translation work. Huang Di Nei Jing (《黄帝内经》 Huangdi's Internal Classic) is the foundation of traditional Chinese medicine (TCM) theory, and is listed as the first of the four classics of TCM. It contains a large number of culture-loaded words, which embody the ancient Chinese traditional culture. The translation of culture-loaded words is a difficult but crucial point in the translation of Huangdi's Internal Classic and directly relates to the quality of the translation of Huangdi's Internal Classic as a whole. Taking the two English versions of Maoshing Ni and Li Zhaoguo as examples, this work identifies the culture-loaded words appearing in the chapter “Yin Yang Ying Xiang Da Lun” (阴阳应象大论 Comprehensive Discourse on Phenomena Corresponding to the Yin and Yang). This work studies the strategies and translation process of culture-loaded words in Huangdi's Internal Classic, with a view to contribute to the English translation of TCM classics.
Confucian Medicine: A Medical Handbook of 19th Century England
Authors: Feng Yu-Rong , Wu Xue-Mei 
Published: July 2022

Abstract
This article takes the “A Medical Handbook” as an example to try to reveal how Western missionaries and Chinese translators jointly translated Western medical knowledge when it was introduced into the East during the 19th century. In this process, the fusion of Chinese and Western medical knowledge led to the Chinese version of A Medical Handbook. Not only did Western missionaries unilaterally promote their medical knowledge, but Chinese local elites also played an indispensable role in the dissemination of Western medical knowledge. In the early days of Western knowledge spreading into China, Western medical knowledge was incorporated into the knowledge pedigree of traditional Chinese medicine to a certain extent, which enabled the Chinese public to accept the use of Western medicine. The collision between Chinese and Western cultures at the level of medical knowledge affected the integration of Western medical knowledge systems into the local Chinese medical knowledge system.
Progress of Research on Aṣtāṅgahṛdaya Saṃhitā
Authors: Zhang Li-Ying , Wang Xing-Yi 
Published: July 2022

Abstract

Aṣtāṅgahṛdaya Saṃhitā (Compendium of the Essence of the Eight Branches)is one of the most important works on Ayurvedic medicine from ancient India. It provides a comprehensive overview and synthesis of Ayurvedic theories from different schools of thought. With concise and clear contents, it was an essential textbook for Ayurvedic medicine in India and many other regions at the time it was written. This article summarizes the main contents of the book, reviews the current status of research, and finds that the modern research on Aṣtāṅgahṛdaya Saṃhitā focuses on religious philosophy, the theory of bodily humors, discussion of drug use, and its relationship with Chinese medicine. The book was widely disseminated in the areas surrounding India and influenced Tibetan and Arabic medicine, as well as multiethnic medicine along the Silk Road.
Systematic Review and Meta-Analysis on the Effect of Transdermal Preparations of Sinomenium Acutum on Rheumatoid Arthritis
Authors: Du Si-Si , Fu Qin-Hui , Pei Jian , Zhou Hua 
Published: July 2022

Abstract

Objective:
We evaluated the efficacy and safety of transdermal preparations of Sinomenium acutum (SA) for rheumatoid arthritis (RA).

Methods:
Randomized controlled trials (RCTs) of SA transdermal preparations for RA were extracted from relevant databases and screened in accordance with the inclusion criteria. The Cochrane System Evaluation Manual (version 5.1.0) was used to assess the quality of the included trials. We used the Cochrane Review Manager (version 5.4) to conduct the meta-analysis.

Results:
Six trials comprising 436 patients (220 patients in the treatment group and 216 patients in the control group) were analyzed. The meta-analysis indicated that SA transdermal preparations in combination with disease-modifying antirheumatic drugs (DMARDs) enhanced the overall effect (odds ratio [OR] 3.97, 95% confidence interval [CI] [2.25, 7.00], P<0.00001), decreased visual analogue scale (VAS) results (mean difference [MD] –0.64, 95% CI [–1.20, –0.09], P=0.02), decreased laboratory indexes including the erythrocyte sedimentation rate (ESR) (MD –4.36, 95% CI [–5.63, –3.08], P<0.00001) and C-reactive protein (CRP) (MD –3.6, 95% CI [–3.99, –3.21, P<0.00001]), and decreased the Disease Activity Score-28 (DAS28) (MD –0.41, 95% CI [–0.78, –0.03], P=0.03). The results suggest that combination therapy did not shorten the duration of morning stiffness (DMS; standardized MD [SMD] –6.13, 95% CI [–17.33, 5.06], P=0.28) or reduce rheumatoid factor (RF) laboratory indexes (SMD –0.85; 95% CI [–2.19, 0.49], P=0.21). Only one study reported adverse reactions, and thus, it was difficult to determine whether adverse drug reactions in the combination therapy group were significantly different from those in the control group.

Conclusion:
We found that SA transdermal preparations combined with DMARDs may have greater clinical efficacy than DMARDs for RA. More well-designed and high-quality RCTs are required to verify the findings and determine whether transdermal preparations cause fewer adverse events.
Discussion of Medicine and Religion: Study of Missionary Hospitals in Modern Shanghai, China
Authors: Chen Lyu-Hua , Chen Li-Yun 
Published: July 2022

Abstract
In modern times, 15 missionary hospitals were established in Shanghai, including 6 Protestant hospitals and 9 Catholic hospitals. These hospitals were the products of Western missionaries in China. The establishment of missionary hospitals objectively introduced Western medicine into China and changed its original medical system. Based on documents and periodicals, Shanghai archives, Xujiahui library materials, hospital historical records, and domestic and foreign library historical materials, this paper systematically reviews the development of missionary hospitals in Shanghai, and discusses their balance between medicine and religion, to provide ideas and references for future research.
Case report: novel mutations of NDUFS6 and NHLRC2 genes potentially cause the quick postnatal death of a Chinese Hani minority neonate with mitochondrial complex I deficiency and FINCA syndrome
Authors: Li Yangfang , Zhang Yu , Jiang Gengpan , Wang Yan , He Canlin , Zhao Xiaofen , Liu Ling , Li Li 
Published: July 2022

Introduction:
Mitochondrial complex I deficiency (MCID) and abbFINCA syndrome are lethal congenital diseases and cases in the neonatal period are rarely reported. Here, we identified a Chinese Hani minority neonate with rare MCID and FINCA syndrome. This study was to analyze the clinical manifestations and pathogenic gene variations, and to investigate causes of quick postnatal death of patient and possible molecular pathogenic mechanisms.

Patient concerns:
A 17-day-old patient had reduced muscle tension, diminished primitive reflexes, significantly abnormal blood gas analysis, and progressively increased blood lactate and blood glucose. Imaging studies revealed pneumonia, pulmonary hypertension, and brain abnormalities.

Diagnosis:
Whole-exome sequencing revealed that the NDUFS6 gene of the patient carried c. 344G > T (p.C115F) novel homozygous variation, and the NHLRC2 gene carried c. 1749C > G (p.F583L) and c. 2129C > T (p.T710M) novel compound heterozygous variation.

Interventions and outcomes:
The patient was given endotracheal intubation, respiratory support, high-frequency ventilation, antishock therapy, as well as iNO and Alprostadil to reduce pulmonary hypertension and maintain homeostatic equilibrium. However, the patient was critically ill and died in 27 days.

Conclusion:
The patient has MCID due to a novel mutation in NDUFS6 and FINCA syndrome due to novel mutations in NHLRC2, which is the main reason for the rapid onset and quick death of the patient.
Effectiveness of a new triple-row circular stapler in reducing the risk of colorectal anastomotic leakage: A historical control and propensity score–matched study
Authors: Mazaki Junichi , Katsumata Kenji , Ishizaki Tetsuo , Fukushima Noritoshi , Udo Ryutaro , Tago Tomoya , Kasahara Kenta , Kuwabara Hiroshi , Enomoto Masanobu , Nagakawa Yuichi , Tsuchida Akihiko 
Published: July 2022

Anastomotic leakage (AL) after colorectal surgery is a serious complication. This study aimed to evaluate the effectiveness of the EEA™ circular stapler, a new triple-row circular stapler (TCS), relative to a conventional, double-row circular stapler (DCS).
A total of 285 patients who underwent anastomosis with the double stapling technique at the Tokyo Medical University Hospital between 2017 and 2021 were included in this nonrandomized clinical trial with historical controls using a propensity score (PS) analysis. The primary endpoint was the risk of AL.
We performed a 1:2 PS matching analysis. Before case matching, AL occurred in 15 (7.4%) and 2 (2.4%) patients in the DCS and TCS groups, respectively, with no significant difference (P = .17). After case matching, AL occurred in 13 patients (11.6%) and 1 patient (1.8%) in the DCS and TCS groups, respectively, revealing a significant difference (P = .04). Cox models were created by applying PS to adjust for group differences via regression adjustment. Odds ratios for AL in the DCS group versus the TCS group were 0.31 (95% confidence interval [CI]: 0.07–1.38) in the entire cohort, 0.15 (95% CI: 0.02–0.64) in the regression adjustment cohort, and 0.14 (95% CI: 0.02–1.09) in the 1:2 PS-matched cohort.
PS analysis of clinical data suggested that the use of TCS contributes to a reduced risk of AL after colorectal anastomosis CTwith the double stapling technique.
Use of high-flow nasal oxygen in spontaneously breathing pediatric patients undergoing tubeless airway surgery: A prospective observational study
Authors: Kim Eun-Hee , Ji Sang-Hwan , Lee Ji-Hyun , Kim Jin-Tae , Jang Young-Eun , Kwon Seong-Keun , Kim Hee-Soo 
Published: July 2022

The use of high-flow nasal oxygen is gaining popularity in apneic and spontaneously breathing adult patients during anesthesia. This prospective observational study evaluated the effect of high-flow nasal oxygen in maintaining adequate oxygenation and ventilation in spontaneously breathing pediatric patients with dynamic airway obstruction, undergoing tubeless airway surgery.
Oxygenation was provided via an age-appropriate, high-flow nasal cannula at a flow rate of 2 L kg−1 min−1. Propofol and remifentanil were used to maintain anesthesia while preserving spontaneous respiration. We sought to determine the incidence and risk factors of rescue ventilation. Rescue ventilation with a face mask was performed when the pulse oximetry oxygen saturation was <90% or transcutaneous carbon dioxide was >80 mm Hg.
In total, 27 patients were included in the final analysis. Median (interquartile range) of pulse oximetry and transcutaneous carbon dioxide were 100% (99%–100%) and 58.4 mm Hg (51.4–70.3 mm Hg), respectively. Altogether, 9 (33.3%) patients needed rescue ventilation during anesthesia. Of these, 7 patients (25.9%) developed oxygen desaturation (<90%) and 2 patients (7.4%) developed hypercarbia. Patients who required rescue ventilation were significantly younger (8.2 vs 28.8 months, P = .02) and required a longer anesthesia time (55.7 vs 41.0 minutes, P = .04) than those who did not.
In conclusion, High-flow nasal oxygen is an alternative technique to maintain oxygenation in children undergoing airway surgeries. However, younger age and longer anesthesia time are significant risk factors leading to the requirement of rescue ventilation in these patients. Further studies with large sample size are required for clinical application of these techniques.
A WeChat-based caregiver education program improves satisfaction of stroke patients and caregivers, also alleviates poststroke cognitive impairment and depression: A randomized, controlled study
Authors: Kang Kaining , Li Shurui 
Published: July 2022

Caregiver education program has been applied to stroke patients, while its effect on mental health in stroke patients is still obscure. This study aimed to assess the impact of the WeChat-based caregiver education (WBCE) program on cognition, anxiety, and depression in stroke patients.
Totally, 170 patients with ischemic stroke were included. They were randomized at a 1:1 ratio to the WBCE group (N = 86) and control care (CC) group (N = 84), and their caregivers received WBCE or CC for 12 months, respectively.
Mini-mental state examination (MMSE) score was increased in the WBCE group compared with that in the CC group at the 9th month (M9) (27.2 ± 1.9 vs 26.6 ± 1.6, P = 0.017) and M12 (27.1 ± 1.8 vs 26.5 ± 1.5, P = 0.015), while cognitive impairment rate was decreased in WBCE group compared with that in CC group at 12th month (M12) (30.2% vs 45.2%, P=0.043). In the meantime, the Hospital Anxiety and Depression Scale (HADS) for Anxiety score (6.5 ± 3.1 vs 7.5 ± 2.8, P = 0.020), HADS for depression score (6.7 ± 3.1 vs 7.7 ± 3.3, P = 0.040) and depression rate (33.7% vs 48.8%, P = 0.046) in WBCE group were reduced compared with those in CC group at M12. Besides, an elevation in the satisfaction score of patients at M12 (8.0 ± 1.2 vs 7.4 ± 1.2, P = 0.002) and that of caregivers at 6th months (M6) (6.6 ± 1.1 vs 6.2 ± 1.3, P = 0.038) and M12 (7.2 ± 1.1 vs 6.8 ± 1.4, P=0.042) were found in WBCE group compared with CC group.
WBCE program not only improves the satisfaction of stroke patients and caregivers but also attenuates cognitive impairment and depression in stroke patients.
A bibliometric analysis of global publications on graft-versus-host disease research
Authors: Huang Xuemiao , Wang Taiwei , Zu Wanting , Xu Tianxin , Du Lin , Wang Yiming , Nie Wenbo , Wang Lisheng 
Published: July 2022

Background:
Graft-versus-host disease (GVHD) is a fatal complication of hematopoietic stem cell transplantation and is an enormous burden on the patient economy and related health systems. Nevertheless, only a few bibliometric studies have examined the direction of research and the major findings within the field.

Methods:
Statistical and visualization bibliometric analysis was performed in April 2021. Our research data were retrieved from the Web of Science using an advanced search strategy. We then used bibliometric analysis to determine the current general research direction and trend of publications and established the most prolific and distinguished authors, institutions, countries, funding agencies, and keywords in GVHD research. We employed VOSviewer (Leiden University, Leiden, Netherlands), Microsoft Excel (Microsoft, Redmond, State of Washington), and GunnMap (https://lert.co.nz/map/) to retrieve, integrate, and visualize the results.

Results:
Overall, 15,378 publications from 500 journals were extracted from the Institute for Scientific Information (ISI) Web of Science Core Collection database based on our analysis, of which the United States and the Fred Hutchinson Cancer Research Center were the most prolific countries and institutions, respectively. Moreover, we identified future research trends and the current status of GVHD research based on the top 10 most cited articles. Finally, influential authors’ analysis demonstrated that Blazar, BR were both the most productive and most cited among all authors.

Conclusion:
Our study provides an exhaustive and objective overview of the current status of GVHD research. This information would be highly beneficial to anyone seeking information on GVHD and would serve as a reference guide for researchers aiming to conduct further GVHD research.
Acquisition of new medical devices among the persistently critically ill: A retrospective cohort study in the Veterans Affairs
Authors: Viglianti Elizabeth M. , Carlton Erin F. , McPeake Joanne , Wang Xiao Qing , Seelye Sarah , Iwashyna Theodore J. 
Published: July 2022

Patients who develop persistent critical illness remain in the ICU predominately because they develop new late-onset organ failure(s), which may render them at risk of acquiring a new medical device. The epidemiology and short-term outcomes of patients with persistent critical illness who acquire a new medical device are unknown.
We retrospectively studied a cohort admitted to the Veterans Affairs (VA) ICUs from 2014 to 2019. Persistent critical illness was defined as an ICU length of stay of at least 14 days. Receipt of new devices was defined as acquisition of a new tracheostomy, feeding tube (including gastrostomy and jejunostomy tubes), implantable cardiac device, or ostomy. Logistic regression models were fit to identify patient factors associated with the acquisition of each new medical device. Among hospitalized survivors, 90-day posthospitalization discharge location and mortality were identified.
From 2014 to 2019, there were 13,184 ICU hospitalizations in the VA which developed persistent critical illness. In total, 30.4% of patients (N = 3998/13,184) acquired at least 1 medical device during their persistent critical illness period. Patients with an initial higher severity of illness and prolonged hospital stay preICU admission had higher odds of acquiring each medical device. Among patients who survived their hospitalization, discharge location and mortality did not significantly differ among those who acquired a new medical device as compared to those who did not.
Less than one-third of patients with persistent critical illness acquire a new medical device and no significant difference in short-term outcomes was identified. Future work is needed to understand if the acquisition of new medical devices is contributing to the development of persistent critical illness.
Diagnostic value of 18F-FDG PET/CT in discriminating between benign and malignant lesions of the ribs
Authors: Choi Sunju , Kim Yong-il , Lee Geun Dong , Choi Sehoon , Kim Hyeong Ryul , Kim Yong-Hee , Kim Dong Kwan , Park Seung-Il , Ryu Jin-Sook 
Published: July 2022

Purpose:
Imaging biomarkers for rib mass are needed to optimize treatment plan. We investigated the diagnostic value of metabolic and volumetric parameters from 18F-fluorodeoxyglucose (FDG) positron-emission tomography/computed tomography (PET/CT) in discriminating between benign and malignant lesions of the ribs.

Patients and methods:
Fifty-seven patients with pathologically proven diagnosis of rib lesions were retrospectively enrolled. The size of rib lesions, the maximum, mean, and peak standardized uptake value (SUVmax, SUVmean, SUVpeak), tumor-to-background ratio (TBR), metabolic tumor volume (MTV), and total lesions glycolysis (TLG) were measured. The FDG uptake patterns (segmental and discrete) and CT findings (soft tissue involvement and fracture) were also reviewed.

Results:
Among the multiple parameters extracted from PET/CT, the MTV of malignant lesions was significantly higher than that of benign lesions (median; 4.7 vs 0.2, respectively, P = .041). In receiver operating characteristics curve analysis, MTV had the largest area under curve of 0.672 for differentiating malignant from benign lesions. For identifying malignant lesions, an MTV threshold of 0.5 had a sensitivity of 85.0%, specificity of 47.1%, positive predictive value of 79.1%, negative predictive value of 57.1%, and accuracy of 73.7%. The presence of adjacent soft tissue involvement around rib lesions showed a significant association with malignancy (odds ratio = 6.750; 95% CI, 1.837–24.802, P = .003).

Conclusions:
The MTV is a useful PET/CT parameter for assisting in the differential diagnosis of suspected malignant lesions of the ribs. CT finding of adjacent soft tissue involvement around rib was significantly associated with malignant lesions of the ribs.
Matched-pair analysis of survival in patients with poorly differentiated versus well and moderately differentiated hypopharyngeal squamous cell carcinoma
Authors: Xia Xin , Liang Ya , Zhu Yingying , Zhu Xiaoli , Diao Wenwen , Chen Xingming 
Published: July 2022

Hypopharyngeal squamous cell carcinoma (HPSCC) is among the most common malignances of the head and neck and is associated with a poor prognosis. Although both differentiation and tumor-node-metastasis stage affect tumor aggressiveness, the effect of differentiation on the prognosis of HPSCC at different stages is unclear. The aim of this study was to compare survival outcomes between patients with poorly differentiated versus well-differentiated and moderately differentiated HPSCC.
Patients with well/moderately differentiated and poorly differentiated HPSCC were matched based on age, sex, smoking status, alcohol use, comorbidity score, tumor stage, and therapeutic strategies. The Kaplan-Meier curve and Cox proportional hazards model were used to analyze survival. A total of 204 patients with newly diagnosed HPSCC were included after matching 102 well/moderately differentiated cases and 102 poorly differentiated cases from Peking Union Medical College Hospital.
Patients with well/moderately differentiated HPSCC had significantly better disease-specific survival (P = .003) and overall survival (P = .006) than patients with poorly differentiated HPSCC. Additionally, multivariable analysis indicated that increased differentiation was associated with a significantly reduced risk of overall death (adjusted hazard ratio, 0.51; 95% confidence interval, 0.34–0.78, P = .002), and death due to disease (adjusted hazard ratio, 0.44; 95% confidence interval, 0.28–0.69, P < .001).
Survival outcomes differed significantly between the well/moderately differentiated and poorly differentiated HPSCC patients. Treatment strategies based on the level of pathological differentiation might be necessary to improve survival outcomes in patients with HPSCC.
Is the incidence of sandwich vertebral fracture higher than that of ordinary adjacent vertebral fracture after PKP?
Authors: Yang Bo , Zhao Yu , Zhao Yangxue 
Published: July 2022

Objective:
To compare the incidence of fracture between sandwich vertebra and ordinary adjacent vertebra after percutaneous kyphoplasty (PKP).

Method:
We analyzed 225 consecutive patients with osteoporotic vertebral compression fractures who underwent PKP between January 2016 and December 2020 at our medical institution. The sandwich vertebrae was located between 2 cement-augmented vertebra and was followed for at least 12 months. The clinical data of patients with sandwich vertebra and ordinary adjacent vertebra were recorded, and the incidence of postoperative fracture between sandwich vertebra and ordinary adjacent vertebra was compared.

Results:
The mean continuous follow-up time was 31.30 ± 18.04 months in patients with sandwich vertebra and 25.85 ± 7.96 months in patients with ordinary adjacent vertebra. It should be noted that the incidence of sandwich vertebral fractures was 10.00%, which was not statistically higher than 3.26% for ordinary adjacent vertebral fractures. However, a significant difference was observed in the cement volume of single vertebral body, procedure time, and bleeding.

Conclusion:
Although the volume of cement in a single vertebral body is less and the procedure time and bleeding are more, the incidence of sandwich vertebral fracture is not higher than that of ordinary adjacent vertebral body.