bluuebunny/crossref_metadata_2025_split huggingface dataset:
Synergetic effects of nano-SiO2/glycerol on the electrical and optical properties of PVA for embedded electronics and optical applications
Authors: Mousa Emad , Taha Eman O. 
Published: September 2022

AbstractThe present study aims to prepare a low-cost, eco-friendly, free-standing film with optimized physical properties. A PVA composite of hard-soft hybrid filler ratio 1:3 (nSiO2:Gl) is prepared by casting. Dynamic mechanical analyses are processed in the frequency range (0.01–9 Hz). Moreover, dielectric studies are performed in the frequency range (50 Hz–5 MHz). Herein, the modified Jonscher equation and electric modulus formalism are used to explain the results. Transmittance and reflectance of studied samples are measured in the UV–Vis range (200–700 nm). Detailed discussions of band structure, refractive index, and optoelectronic parameters are addressed. Remarkably, the results showed that mechanical and electrical properties of PVA can be tuned by careful modulation of glycerol content, whereas optical properties are more sensitive to nSiO2 content. Finally, FTIR and SEM structural analyses investigate the induced structural changes in PVA.
Cross-shelf overturning in geostrophic-stress-dominant coastal fronts
Authors: Yuan Nan , Mitsudera Humio 
Published: September 2022

AbstractCompared to the dynamics of the predominantly geostrophic along-shelf current, our understanding of the cross-shelf dynamics in the Sea of Okhotsk is inadequate despite their importance in water mixing and nutrient entrainment. We investigated the cross-shelf overturning circulation along the East Sakhalin Current, which is a source of nutrients such as iron for the western North Pacific. Here, we reveal that the cross-shelf circulation during winter is characterised by a nearshore upwelling and a shelf-break downwelling under a downwelling-favourable monsoon wind, contrary to a classical Ekman overturning (EOT). This reverse EOT is driven by the internal water stress, which is caused by intensive vertical mixing and geostrophic vertical shear in the shelf-break front produced by riverine discharges from the far-eastern Eurasian Continent. The EOT blocks the Ekman onshore transport from the open ocean, thereby producing a deep mixed layer at the shelf break. Scaling analyses indicate the applicability of this mechanism to various other shelf-break fronts.
Does the Integration of Migrants in the Host Society Raise COVID-19 Vaccine Acceptance? Evidence From a Nationwide Survey in Japan
Authors: Teng Yuanyuan , Hanibuchi Tomoya , Nakaya Tomoki 
Published: September 2022

AbstractResearch indicates that integration contributes to maintaining health among migrants, yet little is known about the association between integration and vaccination acceptance. This study aimed to explore COVID-19 vaccine intention and acceptance, and the association between integration and vaccine hesitancy among migrants in Japan. We conducted an internet survey among migrants in Japan from October 5 to October 14, 2021. Among 1,455 participants, 11.6% reported hesitancy toward COVID-19 vaccination. We found that the overall integration and social integration were associated with the vaccination intention. Some commonly identified barriers (e.g., financial difficulties, language) were not related to COVID-19 vaccination acceptance among migrants in Japan. Highly integrated migrants were less likely to report vaccine hesitancy against COVID-19. To promote COVID-19 acceptance among migrants, customized intervention policies should focus on the migrants with a lower level of integration, especially those with little social connection with the locals.
Recent studies of the molecular mechanism of lusitropy due to phosphorylation of cardiac troponin I by protein kinase A
Authors: Marston Steven 
Published: September 2022

AbstractCa2+ acts on troponin and tropomyosin to switch the thin filament on and off, however in cardiac muscle a more graded form of regulation is essential to tailor cardiac output to the body’s needs. This is achieved by the action of adrenaline on β1 receptors of heart muscle cells leading to enhanced contractility, faster heart rate and faster relaxation (lusitropy) via activation of the cyclic AMP-dependent protein kinase, PKA. PKA phosphorylates serines 22 and 23 in the N-terminal peptide of cardiac troponin I. As a consequence the rate of Ca2+release from troponin is increased. This is the key determinant of lusitropy. The molecular mechanism of this process has remained unknown long after the mechanism of the troponin Ca2+ switch itself was defined. Investigation of this subtle process at the atomic level poses a challenge, since the change in Ca2+-sensitivity is only about twofold and key parts of the troponin modulation and regulation system are disordered and cannot be fully resolved by conventional structural approaches. We will review recent studies using molecular dynamics simulations together with functional, cryo-em and NMR techniques that have started to give us a precise picture of how phosphorylation of troponin I modulates the dynamics of troponin to produce the lusitropic effect.
Circulating expression and clinical significance of LncRNA ANRIL in diabetic kidney disease
Authors: Zhu Yanting , Dai Lixia , Yu Xiangyou , Chen Xintian , Li Zhenjiang , Sun Yan , Liang Yan , Wu Bing , Wang Qiong , Wang Xiaoming 
Published: September 2022

Abstract
Background
Long noncoding RNA ANRIL has been found to be involved in the pathogenesis of diabetic kidney disease (DKD) and is expected to be a new target for prevention of DKD. However, the circulating expression and clinical significance of ANRIL in DKD patients is uncertain. This study aims to explore this issue.

Methods
The study consisted of 20 healthy controls, 22 T2DM patients (normalbuminuria) and 66 DKD patients (grouped as follows: microalbuminuria, n = 23; macroalbuminuria, n = 22 and renal dysfunction, n = 21). The expressions of ANRIL in peripheral whole blood of all participants were measured by RT-qPCR.

Results
The expression of ANRIL was significantly up-regulated in DKD patients (microalbuminuria, macroalbuminuria and renal dysfunction groups) than that in healthy control group. ANRIL was also over-expressed in macroalbuminuria and renal dysfunction groups in comparison with normalbuminuria group. ANRIL expression was positively correlated with Scr, BUN, CysC, urine β2-MG and urine α1-MG; while negatively correlated with eGFR in DKD patients. In addition, ANRIL was the risk factor for DKD with OR value of 1.681. The AUC of ANRIL in identifying DKD was 0.922, and the sensitivity and specificity of DKD diagnosis were 83.3% and 90.5%, respectively.

Conclusion
Our results indicated that highly expressed ANRIL in peripheral blood is associated with progression of DKD. Circulating ANRIL is an independent risk factor of DKD and has a highly predictive value in identifying DKD.
Universities involvement in patent litigation: an analysis of the characteristics of US litigated patents
Authors: Ascione Grazia Sveva , Ciucci Laura , Detotto Claudio , Sterzi Valerio 
Published: September 2022

AbstractSome recent patent infringement litigations initiated by universities have resulted in multi-million dollar damages and have attracted public attention and stimulated research especially among law scholars. In this paper, we build a brand new database that include patents filed by universities at the United States and Trademark Office (USPTO), their characteristics and, eventually, the information about whether they have been used in infringements lawsuits by universities in the years 1990–2019. Our study is articulated in two parts. First, we show that, although it is still a quite rare phenomenon, patent litigation involving universities has been significantly growing in the last 2 decades. Second, we study the characteristics of university patents that have been litigated vis-à-vis non-litigated university patents. In this respect, we find that public universities and non-US universities are less inclined to litigate their patents compared to private and US universities. In addition, we also find that patent quality is an important determinant in the decision of university litigation. This result holds for patents in the Electrical Engineering sector, which is traditionally prone to opportunistic litigation, and no matter what type of university involved (public vs private, or US vs non-US).
The state does not live by warfare alone: War and revenue in the long nineteenth century
Authors: Goenaga Agustín , Sabaté Oriol , Teorell Jan 
Published: September 2022

AbstractPrevious research shows that wars contributed to the expansion of state revenues in the Early Modern period and in the twentieth century. There are, however, few cross-national studies on the long nineteenth century. Using new unbalanced panel data on wars and public revenues from 1816 to 1913 for 27 American and European countries, this article provides new evidence that military conflicts very rarely triggered lasting increases in public revenues during those years. We argue that the uneven diffusion of military innovations reduced the probability that international wars would be sufficiently intense to push state actors to seek additional resources. Moreover, the distinction between international and civil wars was blurred by the opportunities for non-state actors to mobilize military forces comparable to those of the state. Therefore, only very intense international and civil wars had a lasting impact on state revenues, but such conflicts were extremely rare, both in Europe and the Americas.
Eine hohe Lebensqualität reduziert depressive Symptome von Maßregelvollzugspatientinnen und -patienten
Authors: Bortenschlager Ferdinand , Büsselmann Michael , Wolstein Jörg 
Published: September 2022

Zusammenfassung
Einleitung
Die restriktiven Unterbringungsbedingungen im Maßregelvollzug beeinflussen die Lebensqualität und Depressivität der Untergebrachten und damit die psychische Gesundheit und den Behandlungserfolg therapeutischer Maßnahmen.

Ziele
Ziel der Arbeit ist es, eine Übersicht über die Lebensqualität und die Belastung durch depressive Symptome aus Patientensicht zu erhalten. Es soll analysiert werden, welche Bereiche der Lebensqualität im Zusammenhang mit Depressivität stehen, und ob die Dauer der Maßregel Einfluss auf die Depressivität der Untergebrachten nimmt.

Methode
Die Lebensqualität wurde mittels einer an die Gegebenheiten des Maßregelvollzugs adaptierten Version des Fragebogens Measuring the Quality of Prison Life (MQPL) erhoben. Depressivität wurde anhand der Allgemeinen Depressionsskala (ADS) erfragt. Insgesamt nahmen N = 73 Personen an der Studie teil.

Ergebnisse
Die Lebensqualität wurde im Mittel als positiv bewertet. Am höchsten wurde die Beziehung zum therapeutischen Personal eingeschätzt. Es zeigten sich signifikante Unterschiede in der Lebensqualität zwischen depressiv auffälligen und nichtauffälligen Untergebrachten. Die Dauer der Unterbringung war signifikanter Prädiktor für die Depressionswerte suchterkrankter Untergebrachter.

Fazit
Lebensqualität und Depressivität stehen in signifikant negativem Zusammenhang. Zur Verbesserung der Unterbringungs- und Versorgungsqualität sollte das Klinikpersonal die Lebensqualität der Untergebrachten in den identifizierten Bereichen bestmöglich fördern und besonders zum Aufnahmezeitpunkt sowie bei längeren Behandlungsdauern depressive Symptome identifizieren und behandeln. Hierbei sollte ein Augenmerk auf das Erreichen einer stabilen therapeutischen Allianz gelegt werden.
The role of LncRNA LBX2-AS1 in cancers: functions, mechanisms and potential clinical utility
Authors: Su Yuanshuai , Li Chengzhi , Fang Yu , Gu Xinyu , Zheng Qiuxian , Lu Juan , Li Lanjuan 
Published: September 2022

AbstractIncreasingly advanced biology technique has revealed that long non-coding RNAs (lncRNA) as critical factors that exert significant regulatory effects on biological functions by modulating gene transcription, epigenetic modifications and protein translation. A newly emerging lncRNA, ladybird homeobox 2 (LBX2)-antisense RNA 1 (LBX2-AS1), was found to be highly expressed in various tumors. Moreover, it is functionally linked to the regulation of essential tumor-related biological processes, such as cell proliferation and apoptosis, through interactions with multiple signaling molecules/pathways. The important roles played by LBX2-AS1 in cancer initiation and progression suggest that this lncRNA has enormous clinical potential for use as a novel biomarker or therapeutic target. In this article, we retrospectively review the latest advances in research exploring the roles of the lncRNA LBX2-AS1 in oncology field, highlighting its involvement in a comprehensive network of molecular mechanisms underlying diverse cancers and examining its potential applications in clinical practice.
Pharmacogenomics deliberations of 2-deoxy-d-glucose in the treatment of COVID-19 disease: an in silico approach
Authors: Prabhu Navya B. , Vinay Chigateri M. , Satyamoorthy Kapaettu , Rai Padmalatha S. 
Published: September 2022

AbstractThe outbreak of COVID-19 caused by the coronavirus (SARS-CoV-2) prompted number of computational and laboratory efforts to discover molecules against the virus entry or replication. Simultaneously, due to the availability of clinical information, drug-repurposing efforts led to the discovery of 2-deoxy-d-glucose (2-DG) for treating COVID-19 infection. 2-DG critically accumulates in the infected cells to prevent energy production and viral replication. As there is no clarity on the impact of genetic variations on the efficacy and adverse effects of 2-DG in treating COVID-19 using in silico approaches, we attempted to extract the genes associated with the 2-DG pathway using the Comparative Toxicogenomics Database. The interaction between selected genes was assessed using ClueGO, to identify the susceptible gene loci for SARS-CoV infections. Further, SNPs that were residing in the distinct genomic regions were retrieved from the Ensembl genome browser and characterized. A total of 80 SNPs were retrieved using diverse bioinformatics resources after assessing their (a) detrimental influence on the protein stability using Swiss-model, (b) miRNA regulation employing miRNASNP3, PolymiRTS, MirSNP databases, (c) binding of transcription factors by SNP2TFBS, SNPInspector, and (d) enhancers regulation using EnhancerDB and HaploReg reported A2M rs201769751, PARP1 rs193238922 destabilizes protein, six polymorphisms of XIAP effecting microRNA binding sites, EGFR rs712829 generates 15 TFBS, BECN1 rs60221525, CASP9 rs4645980, SLC2A2 rs5393 impairs 14 TFBS, STK11 rs3795063 altered 19 regulatory motifs. These data may provide the relationship between genetic variations and drug effects of 2-DG which may further assist in assigning the right individuals to benefit from the treatment.
Cowpea mild mottle virus, a sometimes problem for French bean crops
Authors: Gambley C. , Nimmo P. , Persley D. , Steele V. , Sharman M. , Campbell P. 
Published: September 2022

AbstractA carlavirus, closely related to cowpea mild mottle virus (CPMMV) and spread by silverleaf whitefly (SLW) was reported affecting fresh market beans in a major Australian growing district in 2016. Further investigations of this virus were completed through regular surveys of crops, weeds and SLW in this district from 2016–2019. Sequencing of the 3'end of the virus genome from a range of samples detected four variants, referred to as CPMMV:A:FB5288 and CPMMV:A:S1 to S3. The distribution of these four variants in survey samples showed the dominant variant in French bean crops as CPMMV:A:FB5288. The surveys also showed disease impacts were limited to autumn and varied over time. This variation is attributed to the influence of rainfall on adult insect vector levels. The experimental host range of CPMMV:A:FB5288 was shown to be limited to the Phaseoleae plant tribe and included the Australian native species, Glycine canescens. French bean varieties showed a range of susceptibilities to this dominant sequence variant from highly tolerant to very susceptible. The tolerant varieties provide the local industry with some options for disease management where previously there were none. Genetic diversity studies further highlight the need for taxonomic reform of the species referred to as CPMMV.
Porosity estimation by neural networks for CO2 storage in Otway site
Authors: Cheong Snons , Yelisetti Subbarao , Park Chan-Hee 
Published: September 2022

AbstractDynamic simulation of CO2 migration requires a variety of modeling parameters fed by geomechanical models. The confidence of these parameters of material groups such as porosity and permeability is crucial in achieving successful simulations. Based on the geomechanical and geophysical parameters, we estimated porosity distributions on the Paaratte Formation in the Otway site, one of the CO2 storage project in Australia. Considering the nonlinear relations between porosity logs and seismic data, we applied the neural network scheme that addresses the porosity value across a whole domain. With only one monitoring well and two injection wells at the site, seismic data are used to restore the spatial absence in porosity. The technique of the neural network was conducted based on the integration of the well logs to the seismic volume and the inversion of acoustic impedance. The results indicated that a correlation value of the well and the seismic tie is 75% and the value between the recorded and the estimated porosity is 87% on average. Further, the time slice maps of porosity at a depth of the injection interval demonstrated a CO2 plume developed in the Paaratte formation of the Otway site.
Classification of COVID19 Patients Using Robust Logistic Regression
Authors: Ghosh Abhik , Jaenada María , Pardo Leandro 
Published: September 2022

AbstractCoronavirus disease 2019 (COVID19) has triggered a global pandemic affecting millions of people. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causing the COVID-19 disease is hypothesized to gain entry into humans via the airway epithelium, where it initiates a host response. The expression levels of genes at the upper airway that interact with the SARS-CoV-2 could be a telltale sign of virus infection. However, gene expression data have been flagged as suspicious of containing different contamination errors via techniques for extracting such information, and clinical diagnosis may contain labelling errors due to the specificity and sensitivity of diagnostic tests. We propose to fit the regularized logistic regression model as a classifier for COVID-19 diagnosis, which simultaneously identifies genes related to the disease and predicts the COVID-19 cases based on the expression values of the selected genes. We apply a robust estimating methods based on the density power divergence to obtain stable results ignoring the effects of contamination or labelling errors in the data and compare its performance with respect to the classical maximum likelihood estimator with different penalties, including the LASSO and the general adaptive LASSO penalties.
Neue Literatur zu Verschwörungstheorien
Authors: Bührer Werner 
Published: September 2022

ZusammenfassungDer Aufsatz gibt einen Überblick über neuere Arbeiten zu Verschwörungstheorien. Ausgehend von der in der einschlägigen Forschung geteilten Erkenntnis, dass politische, sozioökonomische und kulturelle Krisen einen günstigen Nährboden für solche Theorien bilden, wird zunächst dargestellt, wie sich die weltweit grassierende COVID-19-Pandemie auf das Verschwörungsdenken auswirkte – und zwar anhand einiger Neuerscheinungen, die dem Genre der „Verschwörungsliteratur“ zuzurechnen sind. Im Anschluss werden Handbücher vorgestellt, welche den State of the Art der Forschung repräsentieren, sowie Arbeiten, die sich mit Verschwörungserzählungen in der Alltags- und Populärkultur beschäftigen. Danach wird die Rolle von Verschwörungstheorien in verschiedenen politisch extremen Milieus beleuchtet: „Reichsbürger“, Rechtsextremisten und -populisten sowie „Querdenker“. Es folgen eine geschichtswissenschaftliche Studie und ethnografisch-kulturwissenschaftliche Arbeiten, die dafür plädieren, sich einer eigene Überzeugungen infrage stellenden Wirklichkeit zu öffnen. Den Abschluss bilden einige Ratschläge zum Umgang mit entsprechenden Erzählungen und eine kurze Erörterung der Frage, ob man angesichts der Relativierung des Wahrheitsbegriffs durch Produzenten und Multiplikatoren von Verschwörungstheorien besser auf diesen Begriff verzichten sollte. Alles in allem lässt sich konstatieren, dass bislang nur wenige Arbeiten zum Thema auf eigenen empirischen Erhebungen etwa zum Selbstverständnis, zur Motivation oder zum soziodemografischen Hintergrund der Anhänger_innen von Verschwörungstheorien basieren.
Social integration of translocated wildlife: a case study of rehabilitated and released elephant calves in northern Kenya
Authors: Goldenberg Shifra Z. , Chege Stephen M. , Mwangi Nelson , Craig Ian , Daballen David , Douglas-Hamilton Iain , Lamberski Nadine , Lenaipa Moses , Lendira Reuben , Lesowapir Colman , Lokooria Lekilia P. , Mutinda Mathew , Omengo Fred , Rowe Katie , Stacy-Dawes Jenna , Wittemyer George , Owen Megan A. 
Published: September 2022

AbstractConservation translocations have the potential to strengthen populations of threatened and endangered species, but facilitating integration of translocated individuals with resident populations remains a substantial challenge. Developing functional social relationships like cooperative partnerships or establishing clear dominance hierarchies may be critical to integration of released individuals. Developing such relationships has not received much attention in translocation research, especially for long-lived, socially complex animals for which establishment and navigation of social environments is often a lengthy process that requires sustained monitoring to understand. Here, we present a case study of the social associations of African savannah elephant (Loxodonta africana) calves that have been rehabilitated and released into a fenced wildlife sanctuary in northern Kenya with a resident population of elephants. We use focal follows of interactions pre-release and GPS tracking post-release to quantify social associations of calves with each other and with resident elephants at the release site. We demonstrate how this approach supports translocation monitoring by capturing temporal trends in social patterns within and between release cohorts and among released elephants and wild elephants already resident at the site during a transitional soft release period. Our results show that initial post-release social behavior of rehabilitated calves is related to histories of interaction with familiar individuals and cohort membership and that released calves increased their associations with residents over time. This information provides new behavioral insights for guiding elephant release projects, like the strength of relationships within and among release cohorts, the time to integration with the resident population, and the occurrence and increased incidence of societal fission–fusion. Further, this study provides an example of the utility of animal behavior research to achieve and assess progress towards conservation objectives, and to develop monitoring tools for conservation managers.