bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Collaborative Edge Computing Framework for Predictive Maintenance in Nuclear Power Plants
Authors: Feng Yixiong , Wang Yong , Hu Bingtao , Hong Zhaoxi , Tan Jianrong 
Published: November 2022

Abstract
Nuclear power is an indispensable part of modern energy systems. To operate the nuclear power plants safely and reliably, it is crucial to greatly develop the predictive maintenance of nuclear infrastructure with the support of various smart sensors and big data analytics. To this end, this paper proposes a novel collaborative edge computing-enabled solution for predictive maintenance in nuclear power plants, from which a key problem of efficiently allocating some edge computing tasks is formulated. Specifically, considering huge amounts of industrial data are continuously generated during plant operations, we first present a three-layer predictive maintenance computing framework for nuclear power plants. Subsequently, to timely process these data in some distributed and heterogeneous industrial computing nodes, a complicated scheduling optimization model with some interdependent computational tasks is established. To lower the size of model, we also introduce some reduction strategies. Finally, an actual predictive maintenance scenario in nuclear power plant is chosen and some algorithms are taken for comparisons.
Disorders in Fluid Filled Pipeline Structure With Elastic Helmholtz Resonators
Authors: Zeng Qingna , Wang Donghui , Zang Fenggang , Zhang Yixiong , Wang Bihao , Yuan Zhihao 
Published: November 2022

Abstract
This paper studies the influence of hybrid disorders on acoustic transmission characteristic in pipeline with periodic elastic HRs. Band gap structures (BGs) for infinite period are investigated by transfer matrix method and finite element method respectively, and fit well with the corresponding transmission loss (TL) for finite regular periods. By introducing a certain degree of uncertainty level, Interval analysis method is used to convert uncertain parameter problems into two deterministic models. Frequency response function (FRF) for near-periodic structure with single disorder and BGs for quasi-periodic structure with multiple disorders considering cavity radius and periodic length are investigated. The existence of disorders in periodic structure would always reduce attenuation interval and intensity, some disturbance would even change the original acoustic transmission characteristic and excite completely new attenuation zones. The sensitivity of pipeline acoustic vibration transfer characteristic to disorder parameter depends on attenuation mechanism, as for periodic elastic HRs pipeline, acoustic propagation stability is more sensitive to characteristic of locally resonant unit. The work in this paper enriches the stability analysis of pipeline with elastic HRs, which would provide theoretical reference for noise and vibration reduction design in practical engineering applications.
Efficient Dynamic Monte Carlo Simulation in Multi-Physics Coupling Calculation
Authors: ShangGuan Danhua , Yan Weihua , Wei Junxia , Gao Zhiming , Chen Yibing , Ji Zhicheng 
Published: November 2022

Abstract
If particle transport is included in some multi-physics calculation, Monte Carlo method is often used to simulate it and occupies the largest amount of calculation time. So, efficient dynamic Monte Carlo simulation for time-dependent particle transport problem is important, which is inevitably relied on large-scale parallel calculation. Two methods are proposed in this paper. The one is a tally-reduce algorithm which is used in the coupling of transport simulation and burn-up calculation. By reduces the amount of data which should be reduced necessary, this method can decrease the tally-reduce time largely. It can be seen as a new coupling mode for these two processes in MPI environment and will has larger value in cases when model scale is larger relatively compared to sample size. The other method is an adaptive method for setting the sample size of Monte Carlo simulation. Relying on the generalization of the Shannon entropy concept and an on-the-fly diagnosis rule for a entropy value sequence, the adaptive method proposed in this paper can decrease the original huge sample scale to a reasonable level. By numerical test for some non-trivial examples, both algorithms can decrease the calculation time largely while make the results almost unchanged.
Dynamic Analysis and Experimental Study of the Multi-Point Support Structure Based on Similar Theory Under Thermal Environment
Authors: Deng Xi , Liu Qingsong , Zhou Jianming , Xi Chen , Hou Shuo , Liu Qiang , Lu Guangyao , Wei Xudong , Ni Liang 
Published: November 2022

Abstract
For the large high-temperature structure with multiple points of support, the support keys are not only subjected to the self-weight of the structure, but also to the static and dynamic loads in the assembly environment; on the other hand, the nonuniform temperature distribution forms different degrees of thermal stresses on the structure, while the thermal expansion effect has a significant impact on the assembly state of the support keys and the supports. As an over-constrained system, if the extreme assembly relationship between the bearing key and the support occurs, such as jamming, it will further deteriorate the pre-stress condition of the support system and seriously threaten the safety of the structure. Restricted by the size of the structure and test conditions, the scaled model is considered instead of the full-sized structure for dynamics analysis and experimental study to evaluate the safety and reliability of the support system under thermal environment. In this paper, the force state of the bearing system under operation is analyzed by combining numerical simulation and scaled model tests, the possible jamming risk during the application of the bearing is predicted and the corresponding plan is formulated. The effectiveness of the plan is verified by optimizing the clearance factor of the scaled model, which provides a reference for the safe design of multi-point support structures under thermal environment.
High Temperature Oxidation Kinetics of Zr-Sn-Nb Alloy and the Effect of Its Oxide Film Growth On Corrosion Resistance
Authors: Zhao Wanqian 
Published: November 2022

Abstract
Zirconium-based alloys are widely used for fuel claddings particularly in pressurized water reactor. The high temperature oxidation kinetics of Zr-Sn-Nb alloys in steam in the temperature range of 650°C∼1250°C are studied by a modified thermo-gravimetric analyzer. The oxidation rate exponents and oxidation correlation are calculated. The rate transition of kinetic oxidation for Zr-Sn-Nb occur at 1100°C. The microstructure characteristic of the oxide film formed at 1200°C indicated that the oxide layer is constituted of nanometer exquiaxed grains on the outer surface, columnar grains along perpendicular to the O/M interface and quaisi-equxiaxed grains near the O/M interface. The thickness, crystal distribution and grains size of each layer is measured and analyzed. Furthermore, the correlation among the tetragonal phase fraction, the stress, and the microstructural change of the oxide film is schematized and then analyzed. How to obtain the intact columnar grains structures in the oxide and uniform protective oxide film formation are the key to improve the corrosion resistance of zirconium alloys.
Research Status of Spent Fuel Transport Containers
Authors: Wang Changwu , Wang Zhipeng , Sun Qian , Zhang Yuhang 
Published: November 2022

Abstract
The development of nuclear energy will play an important role in the implementation of China’s carbon peaking and carbon neutral strategy. Since China’s first nuclear power plant came into commercial operation, nuclear power generation has reached a total of more than 2.6 trillion kilowatt hours, equivalent to a reduction of carbon dioxide emissions of about 2.1 billion tons. With more nuclear power units coming into operation, the production of spent fuel has also increased exponentially, and spent fuel transportation and off-stack storage have become the most urgent aspects of the back-end of China’s nuclear fuel cycle. The need for large spent fuel transport containers is becoming increasingly urgent as the spent fuel pools in China are becoming full and spent fuel cooled to a certain age needs to be transported to the final disposal site in spent fuel transport containers. The paper investigates the current research status of spent fuel transport containers from three aspects: design and manufacture, test capability and numerical simulation analysis, and gives reasonable suggestions for the development of large spent fuel transport containers in China.
Quality Analysis and Abnormal Repair of Transient Monitoring Data of CPR1000 Unit
Authors: Qian Wangjie , Chen Zhilin , Lv Feng , Zhang Yanwei , Gu Zheng , Chen Xin , Chen Hanming , Fan Nianqing 
Published: November 2022

Abstract
Transient statistics is an important method for nuclear power plants to monitor the stress status and life of primary circuit equipment and pipelines, and to prevent the strength damage and fatigue damage of the primary circuit pressure boundary. The automatic identification technology of nuclear power plant transients developed in recent years helps to understand the state of nuclear power plants and take corresponding actions in time to ensure the safe operation of nuclear power plants. High-quality, accurate transient monitoring data is the basis for transient statistics. In order to improve the quality of transient data, the temperature and pressure data of domestic CPR1000 pressurized water reactor units over the years of transient monitoring were statistically and analyzed, and the common abnormal data forms were determined as “data missing” and “data jumping”. For abnormal transient data, the mean repair method, the interpolation repair method and the repair method based on object characteristics are proposed. The actual case analysis of the transient monitoring data of the domestic CPR1000 pressurized water reactor unit shows that the above method can effectively repair the abnormal points of the transient data, thereby significantly improving the quality of the data, and laying the foundation for the automation of the transient statistics of nuclear power plants.
Study of the Regular Pattern Between the Geometric Characteristics of Radioactive Package and Its External Radiation Dose Rate
Authors: Wang Zhipeng , Wang Changwu , Sun Qian , Zhang Yuhang , Chen Lei 
Published: November 2022

Abstract
In recent years, as an important part of the nuclear technology used in the fields of industry, agriculture, medicine and scientific research, the transportation of radioactive materials has increased rapidly. diversification trend. In order to ensure the safety of relevant staff and the public, countries around the world and the IAEA have made certain regulations and constraints on the external radiation rates of radioactive material transport packages. Taking China as an example, &lt;The Regulations for the Safe Transport of Radioactive Materials&gt; (GB11806-2019) is a national mandatory standard specially formulated in accordance with relevant national laws and regulations to prevent radioactive pollution, improve environmental quality, and regulate the management of radioactive materials transportation. The safety requirements for the transport of radioactive materials under normal transport conditions and transport accident conditions, in which the dose rates on the outer surface of the radioactive material package and at 1m are clearly specified. In practical work, it is often necessary to evaluate the surface of the package at different positions and the dose rate at 1m to ensure transportation safety. Based on several radioactive material transport containers with mature experience, this paper calculates the external radiation levels of various shapes of packages by using mathematical methods, and classifies them according to the geometric characteristics of the containers and the distribution of the contents. The influence of the surface of the location and the variation law of the dose rate at 1m is analyzed to provide a reference for the radiation safety management of radioactive material transportation activities.
Practice of Risk-Informed Nuclear Safety Management in CGN
Authors: Shijun Chen , Wenbo Luo , Zichun Wang , Lihui Chen 
Published: November 2022

Abstract
The development experience of nuclear power industry shows that risk-guided nuclear safety management is an effective means to deal with multi-unit nuclear safety management and improve the flexible operation of nuclear power plants. In order to comprehensively and effectively manage the nuclear safety status of group plant units, based on advanced nuclear safety management methods, CGN has gradually established and improved an independent supervision system for nuclear safety since 2017. After several years of exploration, the evaluation of group plant performance indexes and the importance of abnormal events, the determination of the operation safety state supervision and management action matrix and the corresponding action requirements have been carried out gradually, so as to realize the closed-loop management of the operation state of units. This paper summarizes the implementation of advanced nuclear safety management methods at the group level and proposes the direction for further development.
Development of China’s Nuclear Power Standard System and Brief Comparison With American and French Standards
Authors: Deng Ruiyuan , Wu Feifei , Dong Zhenbang , Liu Shangyuan , Du Jian , Zhang Hongwei , Sun Yecong , Zhang Xueyao 
Published: November 2022

Abstract
China’s nuclear power standards have generally experienced three stages: starting, moderate development and rapid development. Up to now, a PWR nuclear power standard system with clear hierarchy, complete and reasonable structure and meeting the needs of the industry has been basically formed. This paper analyzes the conception, planning principles, main scope and objects, hierarchical structure, project setting and evolution process of China’s nuclear power standard system. Finally, it briefly analyzes the characteristics and current situation of nuclear power standards in the United States and France, and expounds the differences in standardization mechanism and standard technology between the two countries and China.
Nationwide, large-scale implementation of an online system for remote entry of patient-reported outcomes in rheumatology: characteristics of users and non-users and time to first entry
Authors: Glintborg Bente , Jensen Dorte Vendelbo , Terslev Lene , Hendricks Oliver , Østergaard Mikkel , Horskjær Rasmussen Simon , Jensen Mogens Pfeiffer , Adelsten Thomas , Colic Ada , Danebod Kamilla , Kildemand Malene , Loft Anne Gitte , Munk Heidi Lausten , Pedersen Jens Kristian , Østgård René Drage , Møller Sørensen Christian , Krogh Niels Steen , Agerbo Jette , Ziegler Connie , Hetland Merete Lund 
Published: November 2022

AimsIn May 2020, a nationwide, web-based system for remote entry of patient-reported outcomes (PROs) in inflammatory rheumatic diseases was launched and implemented in routine care (DANBIO-from-home). After 1.5 years of use, we explored clinical characteristics of patients who did versus did not use the system, and the time to first entry of PROs.MethodsAll patients followed in DANBIO were informed about DANBIO-from-home by electronic invitations or when attending their clinic. Characteristics of patients who did/did not use DANBIO-from-home in the period after implementation were explored by multivariable logistic regression analyses including demographic and clinical variables (gender, age group, diagnosis, disease duration, use of biological disease-modifying agent (bDMARD), Health Assessment Questionnaire (HAQ), Patient Acceptable Symptom Scale (PASS)). Time from launch to first entry was presented as cumulative incidence curves by age group (<40/40–60/61–80/>80 years).ResultsOf 33 776 patients, 68% entered PROs using DANBIO-from-home at least once. Median (IQR) time to first entry was 27 (11–152) days. Factors associated with data entry in multivariate analyses (OR (95% CI)) were: female gender (1.19 (1.12 to 1.27)), bDMARD treatment (1.41 (1.33 to 1.50)), age 40–60 years (1.79 (1.63 to 1.97)), 61–80 years (1.87 (1.70 to 2.07), or age >80 years (0.57 (0.50 to 0.65)) (reference: age <40 years), lower HAQ (0.68 (0.65 to 0.71)) and PASS ‘no’ (1.09 (1.02 to 1.17). Diagnosis was not associated. Time to first entry of PROs was longest in patients <40 years of age (119 (24–184) days) and shortest in the 61–80 years age group (25 (8–139) days).ConclusionA nationwide online platform for PRO in rheumatology achieved widespread use. Higher age, male gender, conventional treatment and disability were associated with no use.
Infliximab biosimilar-to-biosimilar switching in patients with inflammatory rheumatic disease: clinical outcomes in real-world patients from the DANBIO registry
Authors: Nabi Hafsah , Hendricks Oliver , Jensen Dorte Vendelbo , Loft Anne Gitte , Pedersen Jens Kristian , Just Søren Andreas , Danebod Kamilla , Munk Heidi Lausten , Kristensen Salome , Manilo Natalia , Colic Ada , Linauskas Asta , Thygesen Pia Høger , Christensen Louise Brot , Kalisz Maren Høgberget , Lomborg Niels , Chrysidis Stavros , Raun Johnny Lillelund , Andersen Marlene , Mehnert Frank , Krogh Niels Steen , Hetland Merete Lund , Glintborg Bente 
Published: November 2022

ObjectiveSuccessful uptake of biosimilars in rheumatology is limited by lack of real-world evidence regarding effectiveness of biosimilar-to-biosimilar switching. We investigated infliximab biosimilars CT-P13-to-GP1111 switching among patients with rheumatoid arthritis (RA), psoriatic arthritis (PsA) and axial spondyloarthritis (AxSpA).MethodsObservational cohort study from the DANBIO registry. Patients were classified as originator-naïve or originator-experienced. Retention rates of 1-year GP1111 treatment were explored (Kaplan-Meier). We identified baseline factors (at the time of switch) associated with withdrawal of GP1111 (multivariable Cox-regression analyses with HRs including originator treatment history). Changes in subjective and objective measures of disease activity 4 months before and after the switch were assessed in individual patients.ResultsOf 1605 patients (685 RA, 314 PsA and 606 AxSpA, median disease duration was 9 years, 37% in Clinical Disease Activity Index/Ankylosing Spondylitis Disease Activity Score remission), 1171 were originator-naïve. Retention rates at 1-year were 83% (95% CI: 81% to 85%) and 92% (95% CI: 90% to 95%) for the originator-naïve and originator-experienced, respectively. GP1111 retention rates were higher in originator-experienced compared to originator-naïve with RA (HR=0.4 (95% CI: 0.2 to 0.7)) and PsA (HR=0.2 (95% CI: 0.1 to 0.8)), but not significantly for AxSpA: HR=0.6 (95% CI: 0.3 to 1.2). Lower disease activity was associated with higher retention. Changes in disease activity preswitch and postswitch were close to zero.ConclusionThis real-world observational study of more than 1600 patients with inflammatory arthritis showed high 1-year retention following a nationwide infliximab biosimilar-to-biosimilar switch. Retention was higher in originator-experienced and in patients with low disease activity, suggesting outcomes to be affected by patient-related rather than drug-related factors.
Infection profile of immune-modulatory drugs used in autoimmune diseases: analysis of summary of product characteristic data
Authors: Dey Mrinalini , Bechman Katie , Zhao Sizheng , Fragoulis George E , Smith Catherine , Cope Andrew , Nikiphorou Elena , Hyrich Kimme L , Galloway James 
Published: November 2022

ObjectiveSerious infection remains a concern when prescribing immune-modulatory drugs for immune-mediated inflammatory diseases. The ‘summary of product characteristics’ (SmPCs) provide information on adverse events for example, infections, from clinical trials and postmarketing pharmacovigilance.This review aimed to compare infection frequency, site and type across immune-modulatory drugs, reported in SmPCs.MethodsThe Electronic Medicines Compendium was searched for commonly prescribed immune-modulatory drugs used for: rheumatoid arthritis, spondyloarthritis, connective tissue disease, autoimmune vasculitis, autoinflammatory syndromes, inflammatory bowel disease, psoriasis, multiple sclerosis and/or other rarer conditions.Information was extracted on infection frequency, site and organisms. Frequency was recorded as per the SmPCs: very common (≥1/10); common (≥1/100 to<1/10); uncommon (≥1/1,000 to<1/100); rare (≥1/10,000 to<1/1,000); very rare (<1/10 000).Results39 drugs were included, across 20 indications: 9 conventional synthetic disease-modifying anti-rheumatic drugs (csDMARDs), 6 targeted synthetic DMARDs, 24 biologic (b)DMARDs.Twelve infection sites were recorded. Minimal/no site information was available for most csDMARDs, certolizumab pegol and rituximab. Upper respiratory tract was the most common site, especially with bDMARDs. Lower respiratory, ear/nose/throat and urinary tract infections were moderately common, with clustering within drug groups.Data for 27 pathogens were recorded, majority viruses, with herpes simplex and zoster and influenza most frequent. Variable/absent reporting was noted for opportunistic and certain high-prevalence infections for example, Epstein-Barr.ConclusionOur findings show differences between drugs and can aid treatment decisions alongside real-world safety data. However, data are likely skewed by trial selection criteria and varying number of trials per drug and highlight the need for robust postmarketing pharmacovigilance.
KRAS mutation-induced EndMT of brain arteriovenous malformation is mediated through the TGF-β/BMP-SMAD4 pathway
Authors: Xu Hongyuan , Huo Ran , Li Hao , Jiao Yuming , Weng Jiancong , Wang Jie , Yan Zihan , Zhang Junze , Zhao Shaozhi , He Qiheng , Sun Yingfan , Wang Shuo , Cao Yong 
Published: November 2022

ObjectiveSomatic KRAS mutations have been identified in the majority of brain arteriovenous malformations (bAVMs), and subsequent in vivo experiments have confirmed that KRAS mutation in endothelial cells (ECs) causes AVMs in mouse and zebrafish models. Our previous study demonstrated that the KRASG12Dmutant independently induced the endothelial-mesenchymal transition (EndMT), which was reversed by treatment with the lipid-lowering drug lovastatin. However, the underlying mechanisms of action were unclear.MethodsWe used human umbilical vein ECs (HUVECs) overexpressing the KRASG12Dmutant for Western blotting, quantitative real-time PCR, and immunofluorescence and wound healing assays to evaluate the EndMT and determine the activation of downstream pathways. Knockdown of SMAD4 by RNA interference was performed to explore the role of SMAD4 in regulating the EndMT. BAVM ECs expressing the KRASG12Dmutant were obtained to verify the SMAD4 function. Finally, we performed a coimmunoprecipitation assay to probe the mechanism by which lovastatin affects SMAD4.ResultsHUVECs infected with KRASG12Dadenovirus underwent the EndMT. Transforming growth factor beta (TGF-β) and bone morphogenetic protein (BMP) signalling pathways were activated in the KRASG12D-mutant HUVECs and ECs in bAVM tissue. Knocking down SMAD4 expression in both KRASG12D-mutant HUVECs and ECs in bAVM tissues inhibited the EndMT. Lovastatin attenuated the EndMT by downregulating p-SMAD2/3, p-SMAD1/5 and acetylated SMAD4 expression in KRASG12D-mutant HUVECs.ConclusionsOur findings suggest that the KRASG12Dmutant induces the EndMT by activating the ERK-TGF-β/BMP-SMAD4 signalling pathway and that lovastatin inhibits the EndMT by suppressing TGF-β/BMP pathway activation and SMAD4 acetylation.