bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of Traditional Chinese Medicine on the Cardiovascular Diseases
Authors: Jiang Yang , Zhao Qi , Li Lin , Huang Shumin , Yi Shuai , Hu Zhixi 
Published: March 2022

Background: Traditional Chinese medicine (TCM) is the health care system developed with the help of clinical trials that are based ideally on the scientific model of regulation.Objective: This systematic health care system relies on some specific unique theories and practical experiences to treat and cure diseases, thus enhancing the public’s health.Review Methodology: The current review covers the available literature from 2000 to 2021. The data was collected from journals research articles, published books, thesis, and electronic databases, search engines such as Google Scholar, Elsevier, EBSCO, PMC, PubMed, ScienceDirect, Willey Online Library, Springer Link, and CNKI) searching key terms, cardiovascular disease, traditional Chinese medicines, natural products, and bioactive compounds. Full-length articles and abstracts were screened for the collection of information included in the paper.Results: Clinical trials on the TCM and basic research carried out on its mechanism and nature have led to the application and development of the perfect design of the research techniques, for example, twofold striking in acupuncture that aid in overcoming the limitations and resistances in integrating and applicability of these experiences and trials into the pre-existing biomedical models. Furthermore, TCM has also been utilized from ancient times to treat heart diseases in Asia, particularly in China, and is now used by people in many other areas. Cardiovascular disease (CVD) is mainly developed by oxidative stress. Hence antioxidants can be beneficial in treating this particular disease. TCM has a wide variety of antioxidant components.Conclusion: The current review article summarizes the underlying therapeutic property of TCM and its mechanism. It also overviews the evidence of the mechanism of TCM action in CVD prevention by controlling oxidative stress and its signaling pathway.
Stewed Rhubarb Decoction Ameliorates Adenine-Induced Chronic Renal Failure in Mice by Regulating Gut Microbiota Dysbiosis
Authors: Wang Rui , Hu Baifei , Ye Cheng , Zhang Zhigang , Yin Mingzhu , Cao Qiushi , Ba Yuanming , Liu Hongtao 
Published: March 2022

This study aimed to investigate the protective effect of Stewed Rhubarb (SR) decoction on chronic renal failure (CRF) through the regulation of gut microbiota. Using a CRF mouse model induced by a 0.2% adenine diet, we proved that SR decoction (2.0 g crude SR/kg) significantly reduced the levels of urea and creatinine in plasma of CRF mice, accompanied by the improvement of renal fibrosis and tubular atrophy, amelioration of inflammation, and inhibition of aquaporins damage. Also, SR decoction alleviated gut barrier damage, indicative of the elevated mRNA expression of intestinal mucins and tight junctions. By 16S rDNA sequencing, SR decoction reshaped the imbalanced gut microbiota in CRF mice by statistically reversing the abundance changes of a wide range of intestinal bacteria at family and genus levels, which further led to balance in the production of intestinal metabolites, including short-chain fatty acids (acetic acid, propionic acid, and valeric acid), indole, and bile acids (TUDCA and CDCA). Inversely, SR decoction failed to repress the occurrence of CRF in mice with gut microbiota depletion, confirming the essential role of gut microbiota in SR decoction-initiated protection against CRF. In summary, SR decoction can improve adenine-induced CRF in mice by remolding the structure of destructed gut microbiota community. Our findings shed light on the clinical application of SR decoction in nephropathy treatment.
Intra-Articular Injection of Adipose-Derived Stem Cells Ameliorates Pain and Cartilage Anabolism/Catabolism in Osteoarthritis: Preclinical and Clinical Evidences
Authors: Yan Bo , Lv Shuaijie , Tong Peijian , Yan Li , Chen Zuxiang , Zhou Li , Yuan Qiang , Guo Le , Shan Letian 
Published: March 2022

Background: Osteoarthritis (OA) is the most common joint disorder, lacking disease-modifying treatments. Adipose-derived mesenchymal stem cells (ADSCs) are adult multipotent stromal cells obtained from fat tissue, which holds great potential in treating OA. This study aimed to evaluate the anti-OA efficacy of ADSCs from preclinical and clinical facets and explore the underlying mechanism of action.Methods:In vivo, a single dose of 5 × 105 ADSCs was injected into the knee joints of monoiodoacetate-induced OA rat model. The levels of metabolic and hypertrophic molecules (MMP13, Collagen II, Collagen X) of chondrocytes were measured by immunohistochemistry. In vitro, cell viability assay was conducted to detect the proliferation ability of chondrocytes treated with ADSCs conditioned medium (ADSCs-CM). Quantitative real-time polymerase chain reaction and Western blot assays were applied to explore the mechanism of action of ADSCs. Moreover, a retrospective analysis was conducted to determine the clinical efficacy and safety of ADSCs on OA patients.Results: The animal study showed that ADSCs significantly alleviated OA cartilage lesions in rats, as was confirmed by downregulation of the MMP13 and Collagen X and upregulation of the Collagen II. In vitro data showed that ADSCs-CM promoted the proliferation of chondrocytes, and significantly restored the IL-1β-induced abnormal expressions of molecular markers IL-6, Aggrecan, MMP3, MMP13, Collagen II, Collagen X, ADAMTS5, ADAMTS9, SOX6, and SOX9 in chondrocytes. Such regulatory effects of ADSCs-CM on the proliferation and these anabolic, catabolic, and hypertrophic markers of chondrocytes suggested a paracrine-based mode of action of ADSCs. Furthermore, the clinical data showed that ADSCs reduced pain and repaired cartilage damage in OA patients, with no adverse events.Conclusion: This study demonstrated the anti-OA efficacy, safety, and a paracrine-based mechanism of ADSCs, providing a promising cell-based therapeutic option for OA treatment.
Wu-Mei-Wan Ameliorates Murine Ulcerative Colitis by Regulating Macrophage Polarization
Authors: Yan Shuguang , Wei Hailiang , Jia Rui , Zhen Meijia , Bao Shengchuan , Wang Wenba , Liu Fanrong , Li Jingtao 
Published: March 2022

An increasing body of evidence shows that macrophages play an important role in the pathogenesis of ulcerative colitis (UC). Macrophage polarization and changes in related signaling pathways are reported to have a protective effect on intestinal inflammation. The well-known Chinese medicine Wumeiwan (WMW) has been used to treat diarrhea, one of the main symptoms of colitis, for more than 2,000 years. Increasing evidence shows that WMW can inhibit intestinal inflammation and repair damaged intestinal mucosa, but its effector mechanisms are unknown. Therefore, we studied the prophylactic effects of WMW in dextran sulfate sodium (DSS)-induced UC and its effects on macrophage mechanisms and polarization. The results show that colitis was significantly alleviated in mice in the WMW group, and the secretion and expression of pro-inflammatory factors TNF-α, IL-1, and IL-6 were inhibited in the serum and colonic tissues of mice with WMW-treated colitis, whereas anti-inflammatory factors IL-10, Arg-1, and TGF-β1 were increased. Subsequent studies found that WMW could inhibit M1 polarization and promote M2 polarization in colonic macrophages in DSS-induced colitis mice. Network pharmacology was used to predict potential targets and pathways, and further studies confirmed the related targets The results showed that WMW gradually inhibits the activation of the P38MAPK and NF-κB signaling pathways and further activates the STAT6 signaling pathway. In summary, WMW interferes with the p38MAPK, NF-κB and STAT6 signaling pathways to regulate M1/M2 polarization in macrophages, thereby protecting mice against DSS-induced colitis.
Randomized Clinical Study on the Efficacy of Direct Anterior Approach Combined With Tendon Release and Repair After Total Hip Arthroplasty
Authors: Li Guanbao , Chen Qiuan , Zhou Wei , Li Pinquan , Ma Peng , Liu Tongyuan , Tang Hai 
Published: March 2022

BackgroundTo study the effect of reconstruction of the joint capsule and conjoint tendon on the functional recovery of the hip joint during direct anterior approach (DAA) total hip arthroplasty.MethodsA total of 60 patients who underwent their first total hip arthroplasty surgery were selected. According to the set criteria, the selected patients were divided into observation group A (n = 30) and control group B (n = 30). In group A, the joint capsule and conjoint tendon (superior muscle, internal obturator muscle, and inferior muscle) were repaired in situ, while in group B, only the joint capsule was repaired in situ, and the conjoint tendon was not repaired. The surgical indicators, including hip joint function and clinical efficacy of the two groups, were compared.ResultsAfter 6 months of follow-up in groups A and B, no dislocation occurred. The Harris Hip scores of group A were higher than those of group B at 1-month post-operation, i.e., p &lt; 0.05, as well as the valid muscle strength and conjoint tendon valid tension, were higher in group A than group B at 1-month postoperative follow-up, i.e., p &lt; 0.05.ConclusionDAA for total hip arthroplasty on the premise of reconstructing the joint capsule structure can rebuild the tension of the conjoint tendon, enhance its muscle strength, and significantly improve the joint stability and function of the patient early stage. It is beneficial for the patient's rapid recovery and is worth implementing.
Cardiac Xenotransplantation: Progress in Preclinical Models and Prospects for Clinical Translation
Authors: Singh Avneesh K. , Goerlich Corbin E. , Shah Aakash M. , Zhang Tianshu , Tatarov Ivan , Ayares David , Horvath Keith A. , Mohiuddin Muhammad M. 
Published: March 2022

Survival of pig cardiac xenografts in a non-human primate (NHP) model has improved significantly over the last 4 years with the introduction of costimulation blockade based immunosuppression (IS) and genetically engineered (GE) pig donors. The longest survival of a cardiac xenograft in the heterotopic (HHTx) position was almost 3 years and only rejected when IS was stopped. Recent reports of cardiac xenograft survival in a life-sustaining orthotopic (OHTx) position for 6 months is a significant step forward. Despite these achievements, there are still several barriers to the clinical success of xenotransplantation (XTx). This includes the possible transmission of porcine pathogens with pig donors and continued xenograft growth after XTx. Both these concerns, and issues with additional incompatibilities, have been addressed recently with the genetic modification of pigs. This review discusses the spectrum of issues related to cardiac xenotransplantation, recent progress in preclinical models, and its feasibility for clinical translation.
La jota y la taranta. Ritualidad de la música y la danza en la cultura tradicional aragonesa
Authors: Adamo Manuela 
Published: March 2022

La tarantela ha sido desde hace siglos el remedio musical empleado en Italia para curar a quienes eran picados por la tarántula, llamada de manera simbólica «taranta». En España, las fuentes también conﬁrman la presencia del mismo fenómeno y de su terapia con ese estilo musical y en Aragón con la jota. En el presente estudio se esboza una línea argumental que pone en relación la jota y la tarantela, su posible origen común y su relación con los estados de posesión. Además, se vinculan las características anímicas ligadas con la melancolía que, en contextos sociales de marginación cultural y económica, han desencadenado fenómenos culturales que se han materializado en el empleo de la música y la...
y en España.
Laminated wafer with conductive diamond layer formed by surface-activated bonding at room temperature for micro-electro mechanical system sensors
Authors: Koga Yoshihiro , Yamada Shunsuke , Tanaka Shuji , Kurita Kazunari 
Published: March 2022

Abstract
We propose the use of a laminated wafer with a conductive diamond layer for forming cavities as an alternative silicon-on-insulator wafer for micro-electro mechanical system (MEMS) sensors. Since this wafer has no insulator such as a buried oxide (BOX) layer but a conductive layer, it is not charged during plasma treatment in MEMS sensor fabrication processes. The conductive diamond layer was formed on a base wafer doped with boron of more than 2 × 1021 atoms cm−3 by microwave-plasma-enhanced chemical vapor deposition. The resistivity of this layer was 0.025 Ω cm, and this layer can be selectively etched to a base wafer made of silicon crystal, such as a BOX layer. In addition, a silicon wafer can be bonded to its layer without voids with gaps of more than 2 nm by surface-activated bonding. Therefore, we believe that the laminated wafer studied here is useful for the fabrication processes for MEMS sensors that may otherwise be damaged by plasma treatment.
An Effective Way to Clean the Supply Air along the Height of Buildings with the Help of a Ventilation System Valve
Authors: Литвинова Н. А. , Азаров В. Н. 
Published: March 2022

Постановка задачи. Важнейшей задачей в настоящее является повышение качества очистки поступающего в помещения воздуха с помощью системы эффективной местной вентиляции с очисткой воздуха. Внедрение в проектную практику эффективных способов очистки воздуха в клапанах принудительной вентиляции по высоте здания требует наработки научно обоснованных методов их расчетов и проектирования для зданий в условиях высокого загрязнения атмосферы города. Результаты. Разработаны инженерно-технические методы снижения концентраций газообразных загрязнителей в зданиях с помощью предложенного клапана системы вентиляции. Предложенный способ очистки воздуха от газообразных загрязнителей для помещений зданий позволил получить следующие показатели эффективности: по оксиду углерода (II) в летний период - 93,75 %, в зимний - 95 %, по углеводородам алифатическим - 80,59 и 84,78 %, по фенолу - 79,84 и 80,84 %, по формальдегиду - 71,88 и 75,89 % соответственно. Выводы. Результаты исследования позволяют сделать вывод об эффективности использования разработанного способа очистки поступающего воздуха в помещение с помощью запроектированного клапана системы вентиляции до предельно допустимых концентраций газообразных загрязнителей в помещении.
Statement of the problem. The most important task at present is to improve the quality of cleaning the incoming air into the premises from sources of atmospheric air pollution using an effective local ventilation system with air purification. The introduction into design practice of effective methods of air purification in forced ventilation valves along the height of the building requires the development of scientifically sound methods of their calculations and design for buildings in conditions of high pollution of the city atmosphere. Results. An effective method of cleaning the air from gaseous pollutants for the premises of buildings made it possible to obtain in the summer the cleaning efficiency: for carbon (II) oxide - 93.75%; for aliphatic hydrocarbons - 80.59%, for phenol - 79.84%, for formaldehyde - 71.88%. In winter: for carbon (II) oxide - 95%, for aliphatic hydrocarbons - 84.78%; for phenol - 80.84%, for formaldehyde - 75.89%. Conclusions. The results of the study allow us to conclude about the effectiveness of using the developed method of cleaning the incoming air into the room using the developed valve of the ventilation system to the maximum permissible concentrations of gaseous pollutants in the room.
Higher Plant Conservation Across a Gradient of Increasing Agroecosystems Management Intensity in Western Ethiopia
Authors: Likassa Ebisa , Bekele Tamrat , Nemomissa Sileshi 
Published: March 2022

Human mismanagement of natural forests caused the great loss of ecosystem services because of conversion into modified landscapes. On the other hand, agroecosystems are playing vital role in terms of retaining and conserving certain perennial plants in addition to the small fauna. The main objective of this study is to assess the diversity of woody species and vegetation structure in three coffee systems across an increasing farmers’ management intensity in selected research areas of Western Wollega, Ethiopia. A total of 72 samples (24 per each management systems) were purposively selected from three districts based on the dominant coffee production system and the level of coffee production, which supposed to affect the diversity of tree species for collecting data on woody species. Plant specimens were collected following standard herbarium technique and identified in the field and at national herbarium. A total of 50 woody species were identified. The nonmetric multidimensional scaling (NMDS) ordination and Sorensen distance-based ordination demonstrated that plots of the same coffee system were almost maintained similar species composition and abundance. Diversity of woody species was significantly different among the coffee management systems (P <.0001). Similarly, some of the structural parameters like density, basal area, and shade significantly reduced along the increased coffee management intensity. The study found evidence that the intensification of coffee management was not always the source of biodiversity loss; rather, it is an opportunity for conservation of the locally threatened higher plants. Incorporation of coffee shrubs in the degraded lands or remnant forest patches, integrating coffee in the massive afforestation can be used as an alternative strategy for overstorey plant conservation.
Etnomatematika pada Budaya Lokal Batik Kawung
Authors: Syahdan Muhamad Syahdan Sa'id 
Published: March 2022

Budaya merupakan suatu kebiasaan yang mengandung unsur-unsur nilai penting dan fundamental yang diwariskan dari generasi ke generasi. Kebiasaan-kebiasaan yang dilakukan tidak lepas dari nilai matematika, sehingga memberikan hasil unik dan beragam. Hal ini terlihat dari bentuk dan hasil budaya yang ada khususnya di Indonesia seperti kesenian, bentuk bangunan, ukiran, perhiasan, dan sebagainya. Dalam budaya lokal, terkadang terdapat konsep matematika atau biasa disebut etnomatematika. Batik Kawung merupakan salah satu budaya lokal. Batik Kawung adalah motif batik yang bentuknya berupa bulatan mirip buah kawung (sejenis kelapa atau kadang juga dianggap sebagai aren atau kolang-kaling) yang ditata rapi secara geometris. Tujuan dari penelitian ini adalah untuk mengidentifikasi konsep matematika atau unsur etnomatematika pada Batik Kawung. Penelitian ini merupakan penelitian kualitatif dengan pendekatan etnografi. Hasil dari penelitian ini yaitu terdapat konsep matematika atau unsur etnomatematika pada Batik Kawung yaitu konsep kekongruenan dan kesebangunan serta konsep transformasi geometri, sehingga dapat digunakan sebagai alat peraga atau media dalam pembelajaran matematika.
Can We Estimate the Intensities of Great Geomagnetic Storms (ΔSYM-H ≤ −200 nT) with the Burton Equation or the O’Brien and McPherron Equation?
Authors: Zhao Ming-Xian , Le Gui-Ming , Lu Jianyong 
Published: March 2022

Abstract
We input the solar wind parameters responsible for the main phases of 15 great geomagnetic storms (GGSs; ΔSYM-H ≤ −200 nT) into the empirical formulae created by Burton et al. (hereafter the Burton equation) and by OBrien & McPherron (hereafter the OM equation) to evaluate whether these two equations can correctly estimate the intensities of GGSs. The results show that the intensities of most GGSs estimated by the OM equation are much smaller than the observed intensities. The rms error between the intensities estimated by the OM equation and the observed intensities is 203 nT, implying that the estimated storm intensity deviates significantly from the observed one. The rms error between the intensities estimated by the Burton equation and the observed intensities is 130.8 nT. The relative error caused by the Burton equation for storms with intensities ΔSYM-H<−400 nT is larger than 27%, implying that the absolute error will be large for storms with ΔSYM-H < −400 nT. The results indicate that the two equations cannot predict the intensities of GGSs correctly. On the contrary, the intensity of a GGS estimated by the empirical formula created by Wang et al. can approximate observations better if we select the right weight for the solar wind dynamic pressure, proving that solar wind dynamic pressure is an important factor of GGS intensity. This pressure is overlooked by the ring current injection terms of the Burton and OM equations. This is the reason why the two equations do not effectively estimate GGSs.
The Contribution of M-dwarf Flares to the Thermal Escape of Potentially Habitable Planet Atmospheres
Authors: do Amaral Laura N. R. , Barnes Rory , Segura Antígona , Luger Rodrigo 
Published: March 2022

Abstract
The habitability of planets around M dwarfs (≲0.5 M
⊙) can be affected by the X-rays + extreme UV (XUV) emission of these stars, with flares occasionally increasing the XUV flux by more than 2 orders of magnitude above quiescent levels. This wavelength range can warm and ionize terrestrial planets’ upper atmospheres, which expands the planetary radius and promotes atmospheric loss. In this work, we study the contribution of the XUV flux due to flares on the atmospheric escape of Earth-like planets orbiting M dwarfs through numerical simulations. We considered the first Gyr of planets with initial surface water abundances between 1 and 10 terrestrial oceans (TO), a small primordial hydrogen envelope (≤10−3
M
⊕), and with host-star masses between 0.2 and 0.6 M
⊙. In this parameter range, we find that flares can remove up to two TO more than nonflaring stars, which, in some cases, translates to a doubling of the total water loss. We also find that flaring can increase atmospheric oxygen partial pressures by hundreds of bars in some cases. These results were obtained by adding a new module for flares to the VPLanet software package and upgrading its atmospheric escape module to account for Roche lobe overflow and radiation/recombination-limited escape.
Virgo Filaments. II. Catalog and First Results on the Effect of Filaments on Galaxy Properties
Authors: Castignani Gianluca , Vulcani Benedetta , Finn Rose A. , Combes Francoise , Jablonka Pascale , Rudnick Gregory , Zaritsky Dennis , Whalen Kelly , Conger Kim , De Lucia Gabriella , Desai Vandana , Koopmann Rebecca A. , Moustakas John , Norman Dara J. , Townsend Mindy 
Published: March 2022

Abstract
Virgo is the nearest galaxy cluster; it is thus ideal for studies of galaxy evolution in dense environments in the local universe. It is embedded in a complex filamentary network of galaxies and groups, which represents the skeleton of the large-scale Laniakea supercluster. Here we assemble a comprehensive catalog of galaxies extending up to ∼12 virial radii in projection from Virgo to revisit the cosmic-web structure around it. This work is the foundation of a series of papers that will investigate the multiwavelength properties of galaxies in the cosmic web around Virgo. We match spectroscopically confirmed sources from several databases and surveys including HyperLeda, NASA Sloan Atlas, NASA/IPAC Extragalactic Database, and ALFALFA. The sample consists of ∼7000 galaxies. By exploiting a tomographic approach, we identify 13 filaments, spanning several megaparsecs in length. Long >17 h
–1 Mpc filaments, tend to be thin (<1 h
–1 Mpc in radius) and with a low-density contrast (<5), while shorter filaments show a larger scatter in their structural properties. Overall, we find that filaments are a transitioning environment between the field and cluster in terms of local densities, galaxy morphologies, and fraction of barred galaxies. Denser filaments have a higher fraction of early-type galaxies, suggesting that the morphology–density relation is already in place in the filaments, before galaxies fall into the cluster itself. We release the full catalog of galaxies around Virgo and their associated properties.