bluuebunny/crossref_metadata_2025_split huggingface dataset:
Feasibility of the Transport PLUS Intervention to Improve the Transitions of Care for Patients Transported Home by Ambulance: A Non-Randomized Pilot Study
Authors: Munjal Kevin G , Yeturu Sai Kaushik , Chapin Hugh H , Tan Nadir , Gregoriou Diana , Garcia Daniela , Grudzen Corita , Hwang Ula , Morano Barbara , Neher Hayley , Gorbenko Ksenia , Youngblood Glen , Misra Anjali , Dietrich Stayley , Gonzalez Cyndi , Appel Giselle , Jacobs Erica , Siu Albert , Richardson Lynne D 
Published: April 2022

Abstract
Background: The growing population of patients over the age of 65 faces particular vulnerability following discharge after hospitalization or an emergency room visit. Specific areas of concern include a high risk for falls and poor comprehension of discharge instructions. Emergency Medical Technicians (EMTs), who frequently transport these patients home from the hospital, are uniquely positioned to aid in mitigating transition of care risks and are both trained and utilized to do so using the Transport PLUS intervention. Methods: Existing literature and focus groups of various stakeholders were utilized to develop two checklists: the Fall Safety Assessment (FSA) and the Discharge Comprehension Assessment (DCA). EMTs were trained to administer the intervention to eligible patients in the geriatric population. Using data from the checklists, follow-up phone calls, and electronic health records, we measured the presence of hazards, removal of hazards, presence of discharge comprehension issues, and correction or reinforcement of comprehension. These results were validated during home visits by community health workers (CHWs). Feasibility outcomes included patient acceptance of the Transport PLUS intervention and accuracy of the EMT assessment. Qualitative feedback via focus groups was also obtained. Clinical outcomes measured included 3-day and 30-day readmission or ED revisit. Results: 103 EMTs were trained to administer the intervention and participated in 439 patient encounters. The intervention was determined to be feasible, and patients were highly amenable to the intervention, as evidenced by a 92% and 74% acceptance rate of the DCA and FSA, respectively. The majority of patients also reported that they found the intervention helpful (90%), and self-reported removing 40% of fall hazards; 85% of such changes were validated by CHWs. Readmission/revisit rates are also reported.Conclusions: The Transport PLUS intervention is a feasible, easily implemented tool in preventative community paramedicine with high levels of patient acceptance. Further study is merited to determine the effectiveness of the intervention in reducing rates of readmission or revisit. A randomized control trial has since begun utilizing the knowledge gained within this study. Trial Registration: Not Applicable
Immunochromatography Versus Microscopy for Diagnosis of Amoebiasis in Sohag, Egypt
Authors: Ellah Asmaa Kamal Abd , El-Mawgood Amaal Ahmed Abd , Ahmed Amal Mostafa , Hashem Khoulood Zakaria 
Published: April 2022

Abstract
Background: Amoebiasis; a parasitic infection caused by E. histolytica protozoon, is still a major public health in developing countries. Delay in diagnosis and treatment may lead to fatality. So, rapid and accurate diagnosis plays a critical role in patient’s management. Therefore, this study aimed to evaluate the efficacy of immunochromatographic test (ICT) using RIDA®QUICK Entamoeba test compared with traditional microscopic examination as gold standard for the diagnosis of E. histolytica /dispar infection. Methods: A Cross-sectional study was conducted on 100 patients complaining of dysentery or diarrhea with an age range of 3-62 years, attending Sohag University Hospitals and Endemic Diseases Hospital. All stool samples were examined by direct wet smears, formalin ethyl acetate concentration techniques, staining of the smears using Wiegert’s iron hematoxylin and Modified Ziehl-Neelsen method. Copro-antigen detection in stool sample was by using RIDA®QUICK Entamoeba test. Results: Microscopic examination revealed 43 out of 100 patients (43%) were positives for E. histolytica/dispar. The infection was significantly associated with residence (P value < 0.036) and family size (P value < 0.03) but not associated with gender (P value < 0.471) and age (P value < 0.344). The sensitivity, specificity, PPV and NPV of Rida®Quick Entamoeba tests were 97.67%, 96.49%, 95.45% and 98.21% respectively with an accuracy of 97%. There was no cross-reactivity with other intestinal parasites.Conclusions: Rida® Quick Entamoeba test is a simple, rapid, convenient, sensitive and specific assay for the diagnosis amebiasis and is therefore very suitable for large-scale field applications.
Structural characteristics and biological activities of extracts and secondary metabolites from Millettia phuwuaensis Mattapha &amp; Suddee
Authors: Chaikrueang penpaka , pompimon wilart , Udomputtimekakul Phansuang , Khamto Nopawit , Meepowpan Puttinan , Natetip Pakpoom , Khudngaongam Nuntiya , Wongjaren Napakaon , Khuntee Duangsuda , Michaidi Khwanruethai , Kongbun Khanittha , Chueakhamsao Supaporn , Issariyajongkol Kanyawee , nuntasaen Narong , Suksen Kanoknetr , Chairoungdua Arthit , Limthongkul Jitra , Naparswad Chanita , Pikulthong Suttiporn 
Published: April 2022

Abstract
A study of the phytochemicals of stems, Millettia phuwuaensis. This led to the discovery of solvent extracts and pure substances from chromatography. Compound (1), 7-methoxy-5/,6/-methylenedioxyisoflavone, isoflavonoid, and compound (2), 12-deoxo-12α-hydroxyelliptone, rotenoid were structurally proven using NMR-based spectroscopy. Both extracts and pure compounds were evaluated for their biological activity, including antibacterial activity, AIDs, and cancer. The antibacterial test results of the extracts and pure compound were found to be valuable, MIC is in the range of 12.5-200 mg/mL, in the range of 0.188-6 mg/mL, respectively. Mechanistic anti-AIDs affect RT and MC99 found that ethyl acetate extract inhibited the very high level with IC50 with 75.93 %. It was also found that all extracts were effective in inhibiting AIDs By mechanism MC99 at EC50 at 1.35 µM (TI>2.41). Further, the ethyl acetate extract showed marked cytotoxicity (ED50= 17.58 µg/ml against the SH-SY5Y cancer cell line. Additionally, compound 1 was also exhibited RT, moderately active with IC50 55.19 % inhibition. More than that, compounds 1 and 2 were also exhibited to MC99 at 50% (EC50) values of > 3.01 (TI >1.70) and 1.78 (TI >1.70), respectively.
The Effect of Physical Activity Level on Trait Anxiety in College Students: The Mediating Role of Executive Function
Authors: DONG Zhiwei , WANG Peng , XIN Xin , WANG Jing , ZHAO Jinlei , WANG Xing 
Published: April 2022

Abstract
Objectives: This study aimed to analyze the relationship between physical activity level, executive function, and trait anxiety and focused on investigating the mediating role of the subcomponents of executive functions between different levels of physical activity intensity and trait anxiety.Methods: The International Physical Activity Questionnaire, State-Trait Anxiety Inventory, Stroop task, 1-back task, and More-odd shifting task were used to analyze 248 college students by one-way ANOVA, linear regression analysis, and structural equation modeling analysis.Results: Trait anxiety were significantly correlated with shifting function (r=0.182, P=0.004) and inhibition function (r=0.163, P=0.010) and not with working memory (r=0.056, P=0.385). High-intensity physical activity level was most highly correlated with inhibition function (Beta=-0.144, P=0.024) and working memory (Beta=-0.208, P=0.001), and low-intensity physical activity level was most highly correlated with shifting function (Beta=-0.211, P=0.001). Physical activity level had a 72.31% direct effect on reducing trait anxiety (B=-0.195), with 11.79% mediated by inhibition function (B=-0.023) and 15.90% by shifting function (B=-0.031). High-intensity physical activity level had a direct effect on alleviating trait anxiety in 81.08% (B=-0.150), 9.19% mediated by inhibition function (B=-0.017), and 9.73% mediated by shifting function (B=-0.018). The effect of medium-intensity physical activity level on trait anxiety was 40.91% mediated by inhibition function (B=-0.018) and 56.82% mediated by shifting function (B=0.025). The effect of the low-intensity physical activity level on trait anxiety was mediated 34.62% by inhibition function (B=-0.018) and 65.38% by shifting function (B=-0.034).Conclusion: College students with trait anxiety suffer from impaired inhibition and shifting function. The facilitation effects of physical activity levels on executive function subcomponents were, in descending order, working memory, shifting function, and inhibition function, with high-intensity physical activity level contributing most to the facilitation of working memory and inhibition function, and low-intensity physical activity level contributing most to the promotion of shifting function. Physical activity promotes both inhibition and shifting functions, which in turn affect trait anxiety. The high-intensity physical activity level has a direct effect on trait anxiety, while the anxiolytic effect of medium and low-intensity physical activity level is mediated exclusively through executive functions, with the highest mediating effect of shifting function.
Identification of a 16-MTGs Prognostic Signature in Diffuse large B-cell lymphoma
Authors: Wang Xiaoqin , Feng Pengcheng 
Published: April 2022

Abstract
Background
Diffuse large B-cell lymphoma (DLBCL) is one of the largest lymphoma subcategories. Usually, 50–70% of DLBCL patients can be cured by the standard treatment. But at least one third have bad prognosis. Based on this situation, the research on DLBCL therapy strategies is still indispensable.
Method
A prognostic signature was built according to public data and bioinformatics methods, the stability and reliability was assessed and validated. GSEA was performed to explore the difference between different groups. Consensus clustering and immune infiltration were analyzed comprehensively.
Results
In this work, a signature based on multiple metabolism-associated genes (MTGs) was established, containing 16 MTGs, to aid medical workers to predict the prognosis of DLBCL patients. The accuracy and effectiveness of this signature have been verified by three external validation sets. According to the risk formula, DLBCL patients were divided into high- and low-risk groups, and the survival rate of the low-risk group was significantly higher than that of the high-risk group. Furthermore, Gene set enrichment analysis (GSEA) demonstrated that Beta-alanine metabolism and regulation of actin cytoskeleton signal pathways were enriched in the low-risk group. The actual survival and nomogram-predicted survival matched well both in the training cohort and verification cohorts.
Conclusion
In general, our prognostic signature can provide reliable information for medical workers and has some value for the prognosis of DLBCL.
Household electricity consumption inefficiency and it’s determinants in rural areas
Authors: Basumatary Sijousa , Devi Mridula 
Published: April 2022

Abstract
In this paper we have analysed the electricity consumption inefficiency of households in rural area by using stochastic frontier analysis (SFA) applying single stage one-sided approach on the primary data collected using stratified random sampling. We find the mean efficiency of the households is 77.25 percent where the stochastic demand frontier reveals government subsidy and minimum watt have a significant positive impact on household electricity consumption. Surprisingly, numbers of living room does not increase electricity consumption demand in rural areas.We found the inefficiency factors; a reduction in cut in minutes and cut frequency can reduce the inefficiency of electricity consumption by the households in rural areas. Intuitively, a reduction in cut time duration and number of times electricity is cut in a day on an average can reduce inefficiency of the households by 15 percent and 39 percent respectively. Additionally, households living in pukka floors and having inverter as secondary source of lighting could reduce their inefficiency by 11 and 7 percent respectively. Overall, we found inefficiency in electricity consumption in the rural areas lie more on the supply side constraints compared to the demand side.
Modeling of Organochlorine Pesticides in Surface Water, Sediment and Soil of a Small Pond Watershed
Authors: Uygun Burcu Şimşek , Albek Erdem Ahmet 
Published: April 2022

Abstract
Modern agricultural techniques and inputs should be used to increase the yield and quality of products. The use of pesticides for plant protection products is one of these inputs and is a significant component of modern agriculture. Agricultural runoff is the main reason of nonpoint source pollution, which adversely affects surface and ground water quality. The runoff process drives pesticide transport and fate with high spatial and temporal variability in agricultural watersheds. In this study, the presence of pesticides in the water environment of the Borabey Pond and watershed which is situated in the foothills of Bozdağ to the north of Eskişehir, Turkey is determined by measurements. For this purpose, soil samples from the watershed and sediment and water samples from the pond were taken. In these samples, pesticides were analyzed at regular intervals. Based on the results of the analysis, pesticides currently present in the watershed were modeled assuming the pond as a well-mixed system. The accumulation of pesticides in the watershed was found to be representable by the model. In this study, instead of performing pesticide modeling in a short time period, it is aimed to simulate how the past use is reflected to the present. Model and measurement results are observed to be comparable to each other.
Risk-based stratified primary care for common musculoskeletal pain presentations: qualitative findings from the STarT MSK cluster randomised controlled trial
Authors: Saunders Benjamin , Chudyk Adrian , Protheroe Joanne , Cooper Vincent , Bartlam Bernadette , Birkinshaw Hollie , Foster Nadine E , Hill Jonathan C 
Published: April 2022

Abstract
BackgroundThe STarT MSK cluster randomised controlled trial (RCT) investigated the clinical- and cost-effectiveness of risk-based stratified primary care versus usual care for patients with back, neck, shoulder, knee or multi-site pain. Trial quantitative results showed risk-based stratified care was not superior to usual care for patients’ clinical outcomes, but the intervention led to some changes in GP clinical decision-making. This paper reports a nested qualitative study exploring how risk-based stratified care was perceived and used in the trial, from the perspectives of clinicians and patients.MethodsSemi-structured interviews were conducted with 27 patients, and focus groups and interviews with 20 clinicians (GPs and physiotherapists) in the intervention arm of the trial. Data were analysed thematically and findings explored using Normalisation Process Theory (NPT) and the COM-B model.ResultsRisk-based stratified care (subgrouping and matching treatments) was found to have ‘coherence’ (i.e. made sense) to several clinicians and patients, in that it was well-integrated in practice, and supported clinical decision-making. However, for some GPs stratified care was less ‘meaningful’, as the risk-stratification tool did not fit with usual ways of consulting and added to already time-pressured consultations. GPs reported giving more patients written information/advice due to easier access to electronic information leaflets through the trial template and were motivated to refer patients to physiotherapy as they believed the trial resulted in faster physiotherapy access (although this was not the case). Patients and clinicians reported that risk-based stratified care influenced conversations in the consultation, prompting greater attention to psychosocial factors, and facilitating negotiation of treatment options. Physiotherapists saw benefits in receiving information about patients’ risk subgroup on referral forms.ConclusionThese findings provide context for interpreting some of the trial outcomes, particularly in relation to changes in clinical decision-making when risk-based stratified care was used. Findings also indicate potential reasons for lack of GP engagement with risk-based stratified care. Positive outcomes were identified that were not captured in the quantitative data, specifically that risk-based stratified care positively influenced some GP-patient conversations and facilitated negotiation of treatment options.Trial registration: ISRCTN15366334 (26/04/2016)
Metal flow behaviour and processing maps of high heat resistant steel during hot compression
Authors: Obiko Japheth , Chown Lesley , Whitefield David , Bodunrin Michael 
Published: April 2022

Abstract
This article reports the flow stress behaviour of ASTM A335 P92 steel. Uniaxial isothermal compression experiments were conducted to examine the hot deformation behaviour of P92 steel in a Gleeble® 3500 thermal-mechanical simulator. The test conditions were: 0.01–10 s− 1 strain rate and 850–1000°C deformation temperature. Constitutive equations and processing maps developed were used to describe the hot deformation process. The results showed that the flow stress-strain curves exhibited a dynamic recovery (DRV) behaviour as the dominant softening mechanism. The flow stress decreased with an increase in the deformation temperature or a decrease in strain rate. Using the Arrhenius equation, the stress exponent and the activation energy values were: 8.0 and 487.56 kJmol− 1, respectively. The correlation between the constructed processing maps and microstructure showed that the optimal process parameters occurred at a lower strain rate in the region of 0.1 s− 1 and deformation temperatures of 900–950°C and 1000°C for the steel investigated.
Liver transplantation combined with tyrosine kinase inhibitors for the treatment of hepatic metastatic giant gastrointestinal stromal tumors: a case report and literature review
Authors: Qian Jun Lin , He Yong Zhu , Hu Ze Min , He Kun 
Published: April 2022

Abstract
Background
Surgical resection combined with oral tyrosine kinase inhibitors(TKI) is the most effective treatment for gastrointestinal stromal tumor(GIST) liver metastases. For patients with TKI-resistant and unresectable liver metastatic GIST, there has been a lack of effective treatment measures. Liver transplantation is the last resort for end-stage liver malignancies, and it is worth exploring as a treatment option for GIST liver metastases.
Case presentation:
We report a 38-year-old woman who underwent jejunal stromal tumor resection and TKI(imatinib) therapy 15 years ago for jejunal stromal tumor liver metastases. During the period from 2015 to 2018, the liver metastases continued to grow after the patient stopped taking imatinib voluntarily, and the patient subsequently underwent multiple interventional surgeries and drug treatments, which were still poorly curative. The tumor was deemed unresectable because it filled the entire liver, and the patient subsequently underwent liver transplantation and was treated with imatinib post-operatively, which resulted in no recurrence of the tumor within 13 months of follow-up.
Conclusions
Liver transplantation can be used as a treatment option for patients with unresectable liver metastatic GIST, and combined TKI-targeted therapy can prolong survival to a certain extent.
The pattern of thyroid cancers in Nigeria: a systematic review and meta-analysis
Authors: Azeez Taoreed Adegoke , Iyapo Oluwadamilare , Folorunso Sharif Adeniyi , Onwudijor Chikodi John 
Published: April 2022

Abstract
BackgroundThyroid cancer is the commonest endocrine cancer. There are various histopathological types requiring different therapeutic approaches and having variable prognosis. The objective of this study was to determine the pattern of thyroid cancers in Nigeria.MethodsThe systematically searched databases were African Journal Online, Google Scholar, PubMed and SCOPUS. The pre-print databases Research Square, SciELO and medRxiv were also systematically searched. Moreover, the available grey literature was keenly searched. The meta-analysis was done using Meta XL version 5. The quality of the selected studies was assessed using the Newcastle-Ottawa scale. The DerSimonian Laird random effect model was used for the meta-analysis. Heterogeneity of the selected studies was determined using I2 statistic and the Cochran’s Q test. Publication bias was assessed with the LFK index and Doi plot.ResultsTwenty-six studies met the eligibility criteria. The total sample size was 1224. In Nigeria, thyroid cancer was most common in the 4th and 5th decades of life. It was 3.5 (95%CI: 3.0- 4.6, p<0.0001) times commoner in females than males. The pooled proportions of thyroid cancers included papillary thyroid cancer- 46% (95% CI: 40 -53), follicular thyroid cancer- 39% (95% CI: 32-45), medullary thyroid cancer – 7% (95% CI: 6 -9), and anaplastic thyroid cancer- 5% (95% CI: 3 -7). The trend showed a change from follicular cancer predominance to papillary cancer over the past two decades.ConclusionPapillary thyroid cancer is the commonest type in Nigeria. Thyroid cancer is seen more in females and it occurs most commonly in middle age.
Development and Validation of a Novel Mitophagy-Related Gene Prognostic Signature for Glioblastoma multiforme
Authors: Luo Yujun , wang Jinghua , Qiu Xinqi , Huang Jiayu , Zhuo Zewei , Chen Hao , Zeng Ruijie , Wu Huihuan , Guo Kehang , Yang Qi , Ye Huiling , Huang Wei 
Published: April 2022

Abstract
Background: Glioblastoma multiforme (GBM) is one of the most malignant tumors in brain with high morbidity and mortality. Mitophagy plays a significant role in carcinogenesis, metastasis, and invasion. In our study, we aim to construct a mitophagy-related risk model to predict prognosis in GBM. Methods: RNA-seq data combined with clinical information were downloaded from TCGA. The 4-gene risk model and nomograph was then constructed and validated in external cohort. Evaluation of immune infiltration, functional enrichment and tumor microenvironment (TME) were then performed. Result: A mitophagy-related risk model was established and patients in TCGA and CGGA were classified into low-risk and high-risk groups. In both cohorts, patients in low-risk group had improved survival, while high-risk group have poor prognosis. Also, the risk model was identified as an independent factor for predicting overall survival via Cox regression. Furthermore, a prognostic nomogram including mitophagy signatures was established with excellent predictive performance. In addition, the risk model was closely associated with regulation of immune infiltration as well as TME. Conclusion: In conclusion, our study constructed a mitophagy-related risk model, which can be utilized for the clinical prognostic prediction in GBM.