bluuebunny/crossref_metadata_2025_split huggingface dataset:
Brain activation measurement for motion gain decision of surgical endoscope manipulation
Authors: Miura Satoshi , Kaneko Taisei , Kawamura Kazuya , Kobayashi Yo , Fujie Masakatsu G. 
Published: February 2022

AbstractBackgroundRobotic surgery improves minimally invasive interventions. However, it is challenging to determine the best gain settings for control of the endoscope. Providing the surgeon with the ability to manipulate the endoscope at an appropriate speed will likely improve the surgery by reducing the surgeon's stress. In this study, we validated the feasibility of a gain‐tuning method in which the operator's brain activity is measured and used to evaluate stress levels.MethodsWe developed an endoscope‐manipulation simulator and used functional near‐infrared spectroscopy to measure the prefrontal cortical activity, while participants controlled the simulator at different gain values.ResultsThe brain activation levels in the prefrontal cortex exhibited significant differences under different viewpoint motion gain conditions.ConclusionsThe stress‐related brain activity was significantly reduced at specific gains, indicating that the brain activity evaluation would be useful to determine the parameters related to the operator's feelings.
Systematic review of the efficacy, effectiveness and safety of recombinant haemagglutinin seasonal influenza vaccines for the prevention of laboratory‐confirmed influenza in individuals ≥18 years of age
Authors: O Murchu Eamon , Comber Laura , Jordan Karen , Hawkshaw Sarah , Marshall Liam , O’Neill Michelle , Ryan Máirín , Teljeur Conor , Carnahan Annasara , Pérez Jaime Jesús , Robertson Anna Hayman , Johansen Kari , Jonge Jorgen de , Krause Tyra , Nicolay Nathalie , Nohynek Hanna , Pavlopoulou Ioanna , Pebody Richard , Penttinen Pasi , Soler‐Soneira Marta , Wichmann Ole , Harrington Patricia 
Published: February 2022

AbstractThe most effective means of preventing seasonal influenza is through vaccination. In this systematic review, we investigated the efficacy, effectiveness and safety of recombinant haemagglutinin (HA) seasonal influenza vaccines to prevent laboratory‐confirmed influenza. A systematic literature search was conducted in electronic databases and grey literature sources up to 7 February 2020. Randomised controlled trials and non‐randomised studies of interventions were eligible for inclusion. The search returned 28,846 records, of which 10 studies on recombinant HA influenza vaccine met our inclusion criteria. One study found that the quadrivalent recombinant HA influenza vaccine had higher relative vaccine efficacy (rVE) in preventing laboratory‐confirmed influenza during the 2014–15 season compared with traditional quadrivalent vaccination in adults aged ≥50 years (rVE = 30%, 95% CI 10%–47%, moderate‐certainty evidence). In a subgroup analysis, higher rVE was reported for influenza A (rVE = 36%, 95% CI 14% to 53%), but not for B (non‐significant). Another study reported higher efficacy for the trivalent recombinant HA vaccine compared with placebo (VE = 45%, 95% CI 19–63, 1 RCT, low‐certainty evidence) in adults aged 18–55 years. With the exception of a higher rate of chills (RR = 1.33, 95% CI 1.03–1.72), the safety profile of recombinant HA vaccines was comparable to that of traditional influenza vaccines. The evidence base for the efficacy and effectiveness of recombinant HA influenza vaccines is limited at present, although one study found that the quadrivalent recombinant HA influenza vaccine had higher rVE compared with traditional quadrivalent vaccination in adults aged ≥50 years.
Leaders' sustainability competences and small and medium‐sized enterprises outcomes: The role of social entrepreneurial orientation
Authors: Álvarez‐García José , Hormiga‐Pérez Esther , Sarango‐Lalangui Paul O. , del Río‐Rama María de la Cruz 
Published: February 2022

AbstractThe market for socially conscious products and services has grown exponentially in the last years. Consequently, adding social value is among the great challenges that companies have to face nowadays. In view of this, companies need leaders with a set of specific skills that prepares them to act and compete in this new environment. This is especially true for small and medium‐sized enterprises (SMEs), which are even more dependent on their leaders' competences. The aim of this article is to analyse the influence of leaders' sustainability competences on the social entrepreneurial orientation of SMEs of the tourism sector, as well as the influence of this strategy on the firm's performance. The methodology used to validate the measurement scales is exploratory and confirmatory factor analysis and the structural equation modelling technique is applied to analyse the causal relationships proposed in the model. The results show that sustainability competences positively affect social entrepreneurial orientation; specifically, the social risk‐taking and proactivity competence has a positive influence on the economic and social performance of SMEs, and in particular, on their green innovation performance. These results highlight the key role that leaders' competences have in SMEs' social orientation and thus, the importance of training in competences for sustainable development.
Genetic Polymorphism in Methylenetetrahydrofolate Reductase Chloride Transport Protein 6 (MTHFR CLCN6) Gene is Associated with Keratinocyte Skin Cancer in a Cohort of Renal Transplant Recipients
Authors: Griffin L. , Ho L. , Akhurst R. J. , Arron S. T. , Boggs J. M. E. , Conlon P. , O’Kelly P. , Toland A. E. , Epstein E. H. , Balmain A. , Bastian B. C. , Moloney F. J. , Murphy G. M. , Laing M. E. 
Published: February 2022

Abstract

Background
Renal transplant recipients (RTRs) are at increased risk of keratinocyte cancer (KC), especially cutaneous squamous cell carcinoma (cSCC). Previous studies identified a genetic variant of the Methylenetetrahydrofolate Reductase (MTHFR) gene, C677T, which conferred a risk for diagnosis of cSCC in Irish RTRs.

Objective
We sought to find further genetic variation in MTHFR and overlap genes that may be associated with a diagnosis of KC in RTRs.

Methods
Genotyping of a combined RTR population (n = 821) from two centres, Ireland (n = 546) and the USA (n = 275), was performed. This included 290 RTRs with KC and 444 without. Eleven single nucleotide polymorphisms (SNPs) in the MTHFR gene and seven in the overlap gene MTHFR Chloride transport protein 6 (CLCN6) were evaluated and association explored by time to event analysis (from transplant to first KC) using Cox proportional hazards model.

Results
Polymorphism at MTHFR CLCN6 (rs9651118) was significantly associated with KC in RTRs (HR 1.50, 95% CI 1.17–1.91, p &lt; 0.00061) and cSCC (HR 1.63, 95% CI 1.14–2.34, p = 0.007). A separate SNP, MTHFR C677T, was also significantly associated with KC in the Irish population (HR 1.31, 95% CI 1.05–1.63, p = 0.016), but not American RTRs.

Conclusions
We report the association of a SNP in the MTHFR overlap gene, CLCN6 and KC in a combined RTR population. While the exact function of CLCN6 is not known, it is proposed to be involved in folate availability. Future applications could include incorporation in a polygenic risk score for KC in RTRs to help identify those at increased risk beyond traditional risk factor assessment.
Design, Synthesis, Molecular Docking, Molecular Dynamics and In Vivo Antimalarial Activity of New Dipeptide‐Sulfonamides
Authors: Ezugwu James. A. , Okoro Uchechukwu. C. , Ezeokonkwo Mercy. A. , Hariprasad Kurma. S. , Rudrapal Mithun , Ugwu David. I. , Gogoi Neelutpal , Chetia Dipak , Celik Ismail , Ekoh Ogechi. C. 
Published: February 2022

AbstractA new series of novel dipeptide sulfonamide analogues were designed, synthesized, and screened for their in silico studies and in vivo antimalarial activities. The synthesized compounds (50 mg/Kg) showed significant activity against P. berghei (NK65) with % inhibition values in (5.9 to 64.7 %) range in when compared with reference drug, artemisinin (66.7 %) in a four day suppressive assay. The in silico studies predicted favorable binding affinity of compounds with target protein residues with high dock score against P. falciparum falcipain 2 (FP‐2) and falcipain 3 (FP‐3) proteins in comparison with the reference ligands. The synthesized compounds showed druggable properties, and the predicted (absorption, distribution, metabolism, excretion and toxicities (ADMET) properties were within the acceptable limits. Molecular dynamics simulation study of the most active compound, 8 e was performed in order to further validate the stability of the protein‐ligand complex and the protein‐ligand interactions.
Goldberg Coupling of Thiazole Substituted Aryl Bromide Demands Stoichiometric Copper Compared to Oxazole
Authors: Ahmad Haseen , Ahmed Waqar , Hassan Abbas 
Published: February 2022

AbstractThe C−N functionalization of thiazole appendant aryl halides using copper mediated transformation has the potential as a strategy for late‐stage Goldberg coupling of carboxamide and heteroaryl halide. The C−N coupling of thiazole scaffold in the presence of copper is highly challenging. The current work presents the C−N coupling of various amides with thiazole derivatives that afforded variety of amide products. The 4‐(4‐bromo‐phenyl)‐2‐methylthiazole, 4‐(4‐bromophenyl)‐2‐pyridiythiazole and 4‐(3‐bromophenyl)‐2‐methylthiazole reacted with aliphatic, aromatic and cyclic amides smoothly in the presence of stoichiometric amount of copper iodide and N,N’‐DMEDA resulting in C−N bond formation in high yields. The reaction optimization attest to the requirement of stoichiometric amount of copper for the thiazolyl aryl bromide. While the corresponding oxazole can easily undergo the amide coupling employing only catalytic amount of copper.
Compositional Features of the Light Fraction from One/Two‐Step Effective Cascade Catalytic Hydroconversion of the Extraction Residue from Naomaohu Lignite
Authors: Yang Zheng , Cong Xing‐Shun , Xie Heng‐Shen , Zhang Min , Wei Xian‐Yong 
Published: February 2022

AbstractNaomaohu lignite (NL) was extracted with isometric acetone/carbon disulfide mixed solvent under ultrasonic irradiation. The extraction residue (ER) was subjected to non‐catalytic hydroconversion (NCHC) and one/two‐step cascade catalytic hydroconversion (CHC) in n‐hexane at 300 °C under 4 MPa of H2 over magnetic solid superacid (MSSA) and superbase (MSSB). The NCHC‐soluble portion from the NCHC (SPNCHC) and CHC‐soluble portion from the one/two‐step cascade CHC (SPA, SPB, SPA‐B, and SPB‐A) were analyzed with a gas chromatograph/ mass spectrometer (GC/MS). The results show that the yields of SPA and SPB are 18.65 % and 16.31 %, respectively, which are much higher than that of SPNCHC (1.26 %). According to the analysis with GC/MS, SPA and SPB are rich in phenol, dimethylnaphthalene, cresol, trimethylphenols, and xylenols, while alkanes are the predominant group component in the SPNCHC, indicating that MSSA selectively catalyzed the cleavage of Car−Calk and Calk−O bridged bonds, whereas MSSB tended to cleave Car−O and Calk−O bridged bonds connecting some aromatic rings in the ER. The yield of SPB‐A was as high as 11.07 % and SPA‐B was only 0.59 %. The results showed that more soluble species in the ER could be further released through the cascade CHC procedures. Benzyloxybenzene was used as a coal‐related model compound to probe the possible mechanisms of one/two‐step cascade CHC of the ER.
Glycerol Electrooxidation on Phosphorus‐Doped Pt‐αNi(OH)2/C Catalysts
Authors: Castagna Rodrigo M. , Alvarez Andrea E. , Sanchez Miguel D. , Sieben Juan Manuel 
Published: February 2022

AbstractThis work investigates the electrooxidation of glycerol in an alkaline environment at non‐doped and P‐doped Pt‐αNi(OH)2 nanoparticles supported on oxidized Vulcan XC‐72R carbon. Pt‐αNi(OH)2 and PtP‐αNi(OH)2 particles with sizes in the range of 3–5 nm were obtained via a one‐step chemical reduction approach. The physicochemical characteristics of the as‐prepared catalysts were studied by inductively coupled plasma‐optical emission spectrometry (ICP‐OES), energy dispersive X‐ray (EDX), X‐ray photoelectron spectroscopy (XPS), transmission electron microscopy (TEM), and x‐ray diffraction (XRD) techniques. It was determined that the incorporation of phosphorus lead to the formation of amorphous PtP‐αNi(OH)2 deposits. TEM analysis showed that the incorporation of phosphorus into the bimetallic Pt‐αNi(OH)2 catalyst origins a remarkable reduction in the average size of the nanoparticles with a narrow size distribution. A substantial improvement in the electrocatalytic properties of the Pt‐αNi(OH)2 system toward the oxidation of glycerol was observed through P doping. The P‐doped electrocatalysts developed a mass current density of 60.3 mA mgPt−1 at 765 mV vs. RHE, which is about 5 and 45 times higher than those of commercial PtRu/C (12.3 mA mgPt−1) and as‐synthesized Pt‐αNi(OH)2/C (1.5 mA mgPt−1), respectively. The temperature‐dependent experiments displayed that the apparent activation energy for the reaction is halved upon the addition of phosphorus.
Tuning the Shape of Gold‐Silver Nanocrystals by Separately Controlling the Metal‐Atom Concentration in a One‐Pot Synthesis
Authors: Yuan Zhuangdong , Zhang Gongguo , Zheng Yiqun , Ma Yanyun , Zhang Haifeng 
Published: February 2022

AbstractWe report a niche synthetic strategy to manipulate the shape of gold‐silver (AuAg) nanocrystals based on kinetics control. The success of current work relies on the use of two syringe pumps to add Au and Ag precursor solutions independently at distinct injection rates, which allows the separate control over the feeding rate of Au and Ag atoms, respectively. Such strategy is validated effective in both one‐pot reduction and seeded growth involving spherical and rod‐likes Au seeds. By conducting orthogonal experiments setting two injection rates at three levels, a set of morphologies are obtained. Interestingly, AuAg alloy nanocrystals in the form of multipod, hollow protruded particles, and branched hollow nanoplate, that are rare to obtain via conventional routes, are successfully screened out, exhibiting the unique advantage of this strategy. The current work provides a feasible approach to applying kinetics control over AuAg bimetallic nanocrystals, which could be extended to other noble metals or material combinations.
Copper‐Catalyzed Thiolation of Terminal Alkynes with N‐Thiosuccinimides to Access Alkynyl Sulfides
Authors: Hu Guo‐Qin , Wang Cai , Zhao Fan , Liu Yao‐Wei , Liu Jing‐Hui , Zhao Bin 
Published: February 2022

AbstractAn efficient copper‐catalyzed thiolation of terminal alkynes with N‐thiosuccinimides was developed. The reaction demonstrated an expanded substrate scope and produced various alkynyl sulfides in moderate to good yields. Gram‐scale synthesis and further transformations confirmed the synthetic utility of this methodology. Preliminary mechanistic studies revealed that a Cu(I)/Cu(III) catalytic cycle was probably involved in the process of alkynylthiolation.
Structural Insights into Pyrazoles as Agents against Anti‐inflammatory and Related Disorders
Authors: Priya Deivasigamani , Gopinath Papichettypalle , Dhivya Loganathan Sumathi , Vijaybabu Anandan , Haritha Manoharan , Palaniappan Senthilkumar , Kathiravan Muthu K. 
Published: February 2022

AbstractPyrazole moiety is considered as the most important therapeutic agent for the treatment of inflammation and inflammation associated cancers. Celecoxib, Ramifenazone, Rimonabant and Lonazolac are some of the commercially available pyrazole moieties which are potent COX‐2 inhibitors and also acts in inhibiting various cancers. Recently there are numerous reviews on the biological significance of pyrazole derivatives. However, this review discusses pyrazole derivatives possessing anti‐inflammatory and anticancer activity (COX inhibition) and also illustrates the recent updates on pyrazole research emphasizing on the medicinal chemistry aspects such as the key structural fragments required for the biological activity. There are series of pyrazoles like di‐substituted, tri‐substituted, tetra‐substituted pyrazoles, pyrazole hydrazones, pyrazoles bearing various other heterocycles, bicyclic fused pyrazoles, tricyclic fused pyrazoles, and miscellaneous class of pyrazoles. All these pyrazoles are being researched as COX inhibitors, anti‐inflammatory and against related disorders like cancer.
The predictors of secondary traumatic stress and psychological resilience in healthcare workers during the COVID‐19 pandemic: A cross‐sectional study in Turkey
Authors: Yörük Selda , Acikgoz Ayla , Güler Döndü 
Published: February 2022

AbstractThis study aims to investigate the relationship between predictive factors of secondary traumatic stress (STS), that is, sociodemographic and work characteristics, and the psychological resilience of healthcare professionals working in different regions of Turkey. This cross‐sectional study included 1416 healthcare workers (HCWs). An independent sample t‐test and hierarchical regression analysis were performed to analyse the data. The predictor variables for STS included perception of health, fear of contagion, anxiety about infecting family members, psychological resilience, type of work, having a COVID‐19 diagnosis in the family, and experiencing a loss due to COVID‐19 (p < 0.05). The variables that predicted psychological resilience included socioeconomic status, health status, age, marital status, work experience, and type of work (p < 0.05). A low number of resilient HCWs experienced secondary traumatic stress.
Nano‐Sized Niobium Tungsten Oxide Anode for Advanced Fast‐Charge Lithium‐Ion Batteries
Authors: Guo Changyuan , Liu Ziang , Han Kang , Zhang Liuyang , Ding Xiaoling , Wang Xuanpeng , Mai Liqiang 
Published: February 2022

AbstractThe further demand for electric vehicles and smart grids prompts that the comprehensive function of lithium‐ion batteries (LIBs) has been improved greatly. However, due to sluggish Li+ diffusion rate, thermal runway and volume expansion, the commercial graphite as an important part of LIBs is not suitable for fast‐charging. Herein, nano‐sized Nb14W3O44 blocks are effectively synthesized as a fast‐charge anode material. The nano‐sized structure provides shorter Li+ diffusion pathway in the solid phase than micro‐sized materials by several orders of magnitude, corresponding to accelerating the Li+ diffusion rate, which is beneficial for fast‐charge characteristics. Consequently, Nb14W3O44 displays excellent long‐term cycling life (135 mAh g‐1 over 1000 cycles at 10 C) and rate capability at ultra‐high current density (≈103.9 mAh g‐1, 100 C) in half‐cells. In situ X‐ray diffraction and Raman combined with scanning electron microscopy clearly confirms the stability of crystal and microstructure. Furthermore, the fabricated Nb14W3O44||LiFePO4 full cells exhibit a remarkable power density and demonstrate a reversible specific capacity. The pouch cell delivers long cycling life (the capacity retention is as high as 96.6% at 10 C after 5000 cycles) and high‐safety performance. Therefore, nano‐sized Nb14W3O44 could be recognized as a promising fast‐charge anode toward next‐generation practical LIBs.
Dual‐metal single‐atomic catalyst: The challenge in synthesis, characterization, and mechanistic investigation for electrocatalysis
Authors: Chen Changli , Sun Mengru , Wang Kaixuan , Li Yujing 
Published: February 2022

AbstractDual‐metal single‐atom catalysts (DACs), featuring high atomic utilization efficiency, excellent selectivity, and stability originating from the atomically dispersed nature, have emerged as a new frontier in heterogeneous electrocatalysis due to the synergistic effect between diversified metal active sites in promoting their catalytic activity. In this review, the recent progress and development on the syntheses, characterizations, theoretical uniqueness, and applications for various catalytic reactions and devices (oxygen reduction reaction, oxygen evolution reaction, hydrogen evolution reaction, CO2 reduction reaction, N2 reduction reaction, proton exchange membrane fuel cells) are summarized and reviewed. Specifically, the synergistic effect between the two metal centers and electronic structures of catalysts is systematically discussed. Moreover, the future challenges and prospects in developing practical DACs are proposed as a possible direction for further investigation.
Enhanced efficiency and stability of triple‐cation perovskite solar cells with CsPbIxBr3 − x QDs “surface patches”
Authors: Yang Guang , Zhang Hengkai , Li Siqi , Ren Zhiwei , Fang Guojia , Lei Dangyuan , Li Gang 
Published: February 2022

AbstractPerovskite solar cells (PSCs) with a light‐harvesting three‐dimensional perovskite bulk layer as backbone component have achieved great progress in performance. Nonradiative recombination is one major place to improve efficiency and stability as they cause significant energy loss in PSCs. Additionally, an imperfection in grain boundaries will initiate device degradation. One of the most successful strategies to decrease nonradiative recombination in PSCs is the introduction of reduced dimensional perovskite (e.g., perovskite quantum wells), benefiting the device's efficiency and stability tremendously. Here, instead of quantum wells, mixed‐cation perovskites with ligand‐contained CsPbBrxI3 − x quantum dots (QDs) are prepared, which is shown to function as perovskite healing “surface patches.” Benefiting from the “surface patches” effect, the QDs‐film shows reduced defects and enhancing film quality which lead to the excellent performance of solar cells (enhancing the power conversion efficiency from 19.21% of the control device to 21.71% [22.1% in reverse scan]).
Vanadium‐based metal‐organic frameworks and their derivatives for electrochemical energy conversion and storage
Authors: Zhu Jing , Chen Xiaoyu , Thang Ai Qin , Li Fei‐Long , Chen Dong , Geng Hongbo , Rui Xianhong , Yan Qingyu 
Published: February 2022

AbstractWith the excessive consumption of nonrenewable resources, the exploration of effective and durable materials is highly sought after in the field of sustainable energy conversion and storage system. In this aspect, metal‐organic frameworks (MOFs) are a new class of crystalline porous organic‐inorganic hybrid materials. MOFs have recently been gaining traction in energy‐related fields. Owing to the coordination flexibility and multiple accessible oxidation states of vanadium ions or clusters, vanadium‐MOFs (V‐MOFs) possess unique structural characteristics and satisfactory electrochemical properties. Furthermore, V‐MOFs‐derived materials also exhibit superior electrical conductivity and stability when used as electrocatalysts and electrode materials. This review summarizes the research progress of V‐MOFs (inclusive of pristine V‐MOFs, V/M‐MOFs, and POV‐based MOFs) and their derivatives (vanadium oxides, carbon‐coated vanadium oxide, vanadium phosphate, vanadate, and other vanadium doped nanomaterials) in electrochemical energy conversion (water splitting, oxygen reduction reaction) and energy storage (supercapacitor, rechargeable battery). Future possibilities and challenges for V‐MOFs and their derivatives in terms of design and synthesis are discussed. Lastly, their applications in energy‐related fields are also highlighted.