bluuebunny/crossref_metadata_2025_split huggingface dataset:
Wide field-of-view x-ray imaging optical system using grazing-incidence mirrors
Authors: Matsuyama Satoshi , Inoue Takato , Hata Kentaro , Iriyama Haruhito , Yamauchi Kazuto 
Published: November 2022

A field-curvature-corrected imaging optical system for x-ray microscopy
using only grazing-incidence mirrors is proposed. It combines a Wolter
type I (WO1) mirror pair, which forms a real image, with field
curvature correction (FCC) optics—a convex hyperbolic mirror pair—that
form a virtual image; compensation of the field curvatures realizes a
wide field-of-view (FOV) and high magnification. Ray-tracing and
wave-optics simulations verified the efficacy of the design, for which
a FOV width was 111 µm—4.7 times larger than that for the
uncorrected WO1 design. The addition of FCC optics also produced a
2.3-fold increase in magnification.
Correlation Between Right Ventricular Echocardiography Measurements and Functional Capacity in Patients With Pulmonary Arterial Hypertension
Authors: Woo Joyce L. , DiLorenzo Michael P. , Rosenzweig Eliana , Pasumarti Nikhil , Villeda Gerson Valencia , Berman-Rosenzweig Erika , Krishnan Usha 
Published: November 2022

Background
Accelerometry is an emerging option for real-time evaluation of functional capacity in patients with pulmonary arterial hypertension (PAH). This prospective pilot study assesses the relationship between functional capacity by accelerometry and right ventricular measurements on echocardiography for this high-risk cohort.

Methods
Patients with PAH were prospectively enrolled and underwent 6-Minute Walk Test and cardiopulmonary exercise testing. They were given a Fitbit, which collected steps and sedentary time per day. Echocardiographic data included right ventricular global longitudinal, free wall, and septal strain; tricuspid regurgitant peak velocity; tricuspid annular plane systolic excursion; tricuspid annular plane systolic velocity; right ventricular myocardial performance index; and pulmonary artery acceleration time. Pairwise correlations were performed.

Results
The final analysis included 22 patients aged 13 to 59 years. Tricuspid regurgitant peak velocity had a negative correlation with 6-Minute Walk Test (r = −0.58, P = .02), peak oxygen consumption on exercise testing (r = −0.56, P = .03), and average daily steps on accelerometry (r = −0.59, P = .03), but a positive correlation with median sedentary time on accelerometry (r = 0.64, P = .02). Pulmonary artery acceleration time positively correlated with peak oxygen consumption on exercise testing (r = 0.64, P = .002). There was no correlation between right ventricular strain measurements and functional capacity testing.

Conclusion
In this pilot study, tricuspid regurgitant jet and pulmonary artery acceleration time were the echocardiographic variables that correlated most with accelerometry data. With further echocardiographic validation, accelerometry can be a useful, noninvasive, and cost-effective tool to monitor disease progression in patients with PAH.
BIROKRASI BARU UNTUK NEW NORMAL: TINJAUAN MODEL PERUBAHAN BIROKRASI DALAM PELAYANAN PUBLIK DI ERA COVID-19
Authors: Taufik Taufik , Warsono Hardi 
Published: November 2022

The pandemic Covid-19 that struck Indonesia has given a new order in bureaucracy and changes in work patterns. This kind of condition is faced with bureaucracy to make changes to new normal. This study uses qualitative descriptive methods, with the type of literature research. The results of this study found that there were two dimensions of bureaucracy change, which is the change dimensions of bureaucratic institutions and changes in work system dimensions. In the dimension of bureaucratic institution change occurs over normal disruption in this case Covid-19 requires organizations to make changes to new normal. Where the bureaucracy in organizing public services prioritizes health protocols. While in the dimension of work system there are two options, namely working at home and still working in the office but still pay attention to the health protocol. The condition of Covid-19 has resulted in many innovations in public services based on electronics, so it is necessary to strengthen quality and innovative HR ASN, as well as infrastructure development support. The implications of this research that the success of bureaucracy change are heavily influenced by leadership factors. Leaders who have personality, visionaries, and the sense of power are able to deal with changes in the organization.
PERAN KOMUNITAS KERAJINAN DAUR ULANG SAMPAH (KerDUS) SEBAGAI PROMOTOR EDUKASI ZERO WASTE DI KABUPATEN KENDAL
Authors: Hidayati Nanik , Majid Abdul , Selfia Yeni 
Published: November 2022

The problem of waste nowadays is not merely on the various type always increasing waste, but more importantly is how to break the potential waste chain from its source. Therefore gradual and continuous education on the importance of reducing or eliminating waste is of importance. The KerDUS community, which is one of the volunteer communities of environmental conservation in Kendal Regency, provides education to the public on the importance of clean living without making waste. The purpose of this study is to determine the role of the KerDUS Community in the success of waste education in the Kendal Regency. This study use qualitative descriptive method that describes the role and activities of the KerDUS Community in providing zero-waste education in the Kendal Regency. Data from observations, interviews, documentation, and questionnaires were collected to be analyzed with the stages of data reduction, data presentation, before drawing conclusions. The results of the study show that the KerDUS community has an important role as a motivator for education towards zero waste in Kendal in the form of workshops or routine monthly training, besides education through Islamic groups in all levels of society. The KerDUS community also sends its members to attend trainer of training or the like to improve the members’ abilities and creativity. Various educational activities are also carried out such as the manufacturing of liquid organic fertilizer, eco brick, paragon pipe decorative lights, various plastic crackle flowers, and various coffee packaging creations. It is hoped that the small KerDUS community can provide a change to the zero-waste lifestyle not only to the people in Kendal Regency but also for a wider society in other regions with the support of relevant agencies and the government.
Analisis Penerapan E-Government Dalam Peningkatan Kualitas Pelayanan Administrasi Kependudukan Pada Mal Pelayanan Publik Bojonegoro
Authors: Amatulloh Dhani 
Published: November 2022

This study focuses on the application of e-government in the quality of public administration services at the Bojonegoro Public Service Mall. The establishment of this Public Service Mall is an effort to create one stop services. The aim of the Government of Bojonegoro Regency takes the initiative to create a Public Service Mall is to make the community easier to manage various types of services. The purpose of this study was to investigate the implementation of e-government on the quality of public administration services and the inhibiting and supporting factors of the implementation of e-government, and to formulate strategies to increase the success of e-government implementation carried out by the Department of Population and Civil Registration at the Bojonegoro Public Service Mall. This study employed a descriptive approach. Data collection techniques were carried out by observation, interviews, and documentation. The data analysis were carried out by data collection (data collection), data reduction (data reduction), data display (data display), verification and confirmation of conclusions (Conclusion drawing and verification). The results of the study, according to formulated by R. Eko Indrajit (in Azkiya, 2018: 4), elucidate the following: 1, Efficiency: The public administration service process through the Si N'duk application, there has been no convenience, speed, and time efficiency because the application was not working optimally. 2. Effectiveness: there were system constraints that make the program less effective. 3. Transparency: Socialization of Si N'duk application and the availability of information both about work programs and other matters regarding to public services existed. 4. Accountability: there was a clarity of employee accountability mechanism in inputting data from Si N'duk application. 5. Empowerment: there was socialization from the office to the sub-district. Supporting factors of Si N'duk application were the support from the Regency Government in encouraging online media to disseminate information related to Si N'duk application and the support from internal employees. Meanwhile, the inhibiting factors were the lack of budget, network or system disturbances, and many people have no understanding and knowledge about Si N'duk application. Keywords: E-Government, Public Service Mall, Public Administration.
Wissensnetz der Zürcher Ehedaten des 16.–18. Jahrhunderts: Eine Anwendung von Semantic-Web-Technologien im Archiv
Authors: Plüss Rebekka , Padlina Roberta 
Published: November 2022

Zusammenfassung
In einem Pilotprojekt hat das Staatsarchiv des Kantons Zürich den Bestand der Zürcher Ehedaten des 16.–18. Jahrhunderts mittels Semantic-Web-Technologien als Wissensnetz aufbereitet. Dabei wurden aus dem swissuniversities Projekt NIE-INE entwickelte Ansätze und Erkenntnisse aufgegriffen und ein modulares Verfahren entwickelt, bei dem Anwendungsfall für Anwendungsfall implementiert wird und an dessen Ende immer ein konsistentes und kontrollierbares Wissensrepräsentationssystem aus Ontologien und Graphdaten steht.
Wie geht bedarfsorientiertes Forschungsdatenmanagement?
Authors: Helling Patrick 
Published: November 2022

Zusammenfassung
Das Management digitaler Forschungsdaten ist ein zentraler Aspekt im Wissenschaftsbetrieb. Bereits lange unterstützen Datenzentren und Servicestellen Forschende bei Fragen zum Forschungsdatenmanagement (FDM). Dabei sollten sich die Organisation und inhaltliche Ausgestaltung dieser Servicestrukturen an den täglichen FDM-Bedarfen der Forschenden orientieren. Mit diesem Beitrag soll ein entsprechender Ansatz für ein bedarfsorientiertes FDM in den Geisteswissenschaften vorgestellt und diskutiert werden. Im Fokus stehen dabei die Beratungs- und Protokollierungspraxis des Data Center for the Humanities (DCH) an der Universität zu Köln sowie konkrete Methoden zur Identifizierung und Modellierung von FDM-Bedarfskategorien und -workflows zur formalen Beschreibung von geisteswissenschaftlichem FDM.
Die „neue“ Schleswig-Holsteinische Landesbibliothek als Dritter Ort: Konzeptionelle Überlegungen und Umbauplanungen
Authors: Lätzel Martin , Grund Sonja 
Published: November 2022

Zusammenfassung
Die Schleswig-Holsteinische Landesbibliothek ist in einem historischen Speicher am Hafen in Kiel zur Miete untergebracht. Das Bemühen der Eigentümer, dieses Haus stärker gegenüber der Stadt zu öffnen, traf auf einen Moment, da die Landesbibliothek sich ebenfalls stärker dem Thema Vermittlung und Bildung widmen will. Gemeinsam wird nun eine Neugestaltung geplant. Die Eigentümer kümmern sich um den Baubestand, die Landesbibliothek wird spezifische Einbauten beauftragen, um das Konzept eines Dritten Orts und die Vermittlung der Digitalität erfüllen zu können.
Brixen – der lange Weg zur neuen Stadtbibliothek
Authors: Kaser Bruno 
Published: November 2022

Zusammenfassung
Im Oktober 2021 wurde nach langer Warte- und Planungszeit die neue Stadtbibliothek Brixen eröffnet. Das größte Wohnzimmer der Stadt, wie die Bibliothek von der Presse gerne bezeichnet wird, präsentiert sich als Zusammenspiel alter Bausubstanz und moderner Architektur direkt im historischen Zentrum, am Domplatz der Stadt. Auf über 2 000 m² bietet die Bibliothek nicht nur ein breitgefächertes Medienangebot, sondern auch Lern- und Studienräume, Veranstaltungssäle sowie einen großzügigen Lesegarten. Der Wunsch der Bibliotheksleitung, die Funktion der Bibliothek als Ort der Begegnung und des Austausches in den Vordergrund zu stellen, konnte realisiert werden.
A multimodal analysis of the online translanguaging practices of international students studying Chinese in a Chinese university
Authors: Tao Jian , Zhao Ke , Dong Wenjuan 
Published: November 2022

Abstract
Previous research has recognised the value of translanguaging in Chinese language teaching but has focused primarily on using English as the medium of instruction. However, teachers and students may not share a common language with which to communicate in a multilingual class, which is a significant challenge in Chinese learning and teaching. This study incorporates translanguaging into the pedagogical design by implementing a translanguaging-based task, perceiving Chinese learners as creative agents orchestrating numerous semiotic resources in meaning-making. The participants were a cohort of beginner-level Chinese learners with diverse ethnolinguistic backgrounds taking an online Chinese course at a Chinese university. Data sources included the participants’ video-recorded oral presentations and their reflective journals. Drawing on social semiotic theory, analysis of the video recordings shows that the learners moved creatively between modalities (written and spoken, visual and auditory, gesture and drawing) that worked together as an assemblage to make meaning beyond their linguistic capacity while ensuring audience comprehension. The reflective journals, however, reveal ambivalent attitudes: using multilingual resources eased concerns about the audience’s reception of the participants’ meaning-making, but also generated guilt among the participants. Based on these findings, this study argues for the transformative power of translanguaging-based pedagogy and highlights the communicative affordance of semiotic resources including cultural artefacts and knowledge. The pedagogical implications of designing translanguaging-based tasks in the teaching of Chinese and other Asian languages are discussed.
Diagnostic performance of machine learning models using cell population data for the detection of sepsis: a comparative study
Authors: Aguirre Urko , Urrechaga Eloísa 
Published: November 2022

Abstract

Objectives
To compare the artificial intelligence algorithms as powerful machine learning methods for evaluating patients with suspected sepsis using data from routinely available blood tests performed on arrival at the hospital. Results were compared with those obtained from the classical logistic regression method.

Methods
The study group consisted of consecutive patients with fever and suspected infection admitted to the Emergency Department. The complete blood counts (CBC) were acquired using the Mindray BC-6800 Plus analyser (Mindray Diagnostics, Shenzhen, China). Cell Population Data (CPD) were also recorded. The ML and artificial intelligence (AI) models were developed; their performance was evaluated using several indicators, such as the area under the receiver operating curve (AUC), calibration plots and decision curve analysis (DCA).

Results
Overall, all the tested approaches obtained an AUC>0.90. The logistic regression (LR) performed well compared to the ML/AI models. The naïve Bayes and the K-nearest neighbour (KNN) methods did not show good calibration properties. The multi-layer perceptron (MLP) model was the best in terms of discrimination, calibration and clinical usefulness.

Conclusions
The best performance in the early detection of sepsis was achieved using the ML and AI models. However, external validation studies are needed to strengthen model derivation and procedure updating.
Influence of filler material on properties of fiber-reinforced polymer composites: A review
Authors: Ramesh Manickam , Rajeshkumar Lakshmi Narasimhan , Srinivasan Nagarajan , Kumar Damodaran Vasanth , Balaji Devarajan 
Published: November 2022

Abstract
The current day target for material scientists and researchers is developing a wholesome material to satisfy the parameters such as durability, manufacturability, low cost, and lightweight. Extensive research studies are ongoing on the possible application of polymer matrix composites in engineering and technology, since these materials have an edge over conventional materials in terms of performance. Hybridization of reinforcements is considered to be a better option to enhance the efficiency and performance of composite materials. Accordingly, research studies focus on the surface treatment of natural fibers and the addition of nanofillers (natural or synthetic) by industry and academia to take the properties and application of composites to the next level. This review purely focuses on the influence of fillers on the properties of composites along with the probable application of filler-based polymer composites.
Effects of intensity and training on cardiovascular responses to the Valsalva maneouvre
Authors: Drury Kathryn , Green Simon 
Published: November 2022

AbstractObjectivesTo establish the effect of intensity of effort during Valsalva’s manoeuvre (VM) on blood pressure and heart rate responses.MethodsFourteen participants consisting of eight powerlifters and six controls completed four 15-s VMs at 30 and 50% maximum expiratory pressure. Expiratory pressure (EP), systolic blood pressure (SBP), diastolic blood pressure (DBP) and heart rate (HR) were recorded continuously during manoeuvres and response amplitudes were related to well-established phases (I–IV).ResultsFor all participants, SBP and DBP responses during Phase I were significantly higher at 50% EPmaxthan 30% EPmax. Phase II responses were significantly higher at 50% EPmaxthan 30% EPmaxfor HR (39.9 ± 24.3 vs. 24.5 ± 12.5 bpm), SBP (43.6 ± 24.6 vs. 35.3 ± 18.3 mm Hg) and DBP (26.7 ± 7.1 vs. 21.1 ± 7.4 mm Hg). For Phase IV, only the HR response was affected significantly by intensity. These intensity-dependent effects were similar between powerlifters and controls. Powerlifters had significantly greater Phase II responses (HR, SBP and DBP), but in the whole group these cardiovascular responses were also significantly correlated with expiratory pressure (mm Hg) at 30% EPmax(r=0.59–0.84) and 50% EPmax(r=0.53–0.82) which was higher in powerlifters than controls.ConclusionsThis study demonstrates that heart rate and blood pressure responses during Phase II are affected by the relative intensity of VM, whereas during Phase IV only heart rate is affected. The higher Phase II responses in powerlifters can be attributed to the higher expiratory pressures they developed.
Effect of aspirin on the TNF-α-mediated cell survival and death pathways in breast cancer
Authors: Thakur Banita , Saha Lekha , Dahiya Divya , Bhatia Alka 
Published: November 2022

Abstract

Objectives
Aspirin is an anti-inflammatory drug commonly used as an analgesic and in cardiovascular disorders. However, many studies have highlighted its anti-cancer properties, especially in colorectal, lung, head and neck, and breast cancers. In this work, we tried to study the effect of aspirin on the TNF-α-mediated cell survival and death pathways in two cell lines representing two different subtypes of breast cancer. TNF-α-mediated stimulation of a cell can result in its proliferation via the NF-κB pathway or its death via either apoptosis or a programmed form of necrosis called necroptosis. The latter is believed to come into the picture only when apoptosis is inhibited.

Methods
In this work, we studied the effect of aspirin on the TNF-α-mediated cell survival pathway and observed a decrease in expression of the NF-κB pathway regulators, its nuclear translocation, and phosphorylation in a dose-dependent manner. The effect of aspirin on the TNF-α-mediated cell death showed significant cytotoxicity at the higher doses (5–20 mM) of aspirin in both the breast cancer cell lines. The effect of aspirin on necroptosis was investigated after stimulating the cells with TNF-α and inhibiting apoptosis using Z-VAD-FMK.

Results
Though no significant effect was noted in breast cancer cell lines, the above protocol successfully induced necroptosis in L929, i.e., a positive control cell line for necroptosis having an intact necroptosis machinery. Even when combined with the chemotherapeutic drugs, the above regime failed to induce any significant necroptosis in breast cancer cells but was found effective in L929.

Conclusions
Overall, the findings show that while aspirin has the potential to inhibit the TNF-α-mediated cell survival pathway, it does not help sensitize breast cancer cells to necroptotic cell death induction.
Palpatory tests in manual therapies: an international survey on osteopathic clinical practice
Authors: Novelli Emanuele , Molinari Livio , Consolo Stefano , Mingrone Luca 
Published: November 2022

Abstract

Objectives
The primary aim of the study is to explore the knowledge and use of palpatory tests in detecting somatic dysfunction, the second is to assess the knowledge about the inhibitory tests among osteopathic practitioners in Italy, England, and France.

Methods
A quantitative survey was conducted, between March and May 2021, through the administration of a semi-structured questionnaire. The participants had to answer 8 questions.

Results
A total of 2,223 e-mails were sent: 423 manual therapy professionals participated in the survey. Subsequently, only the responses of the 385 osteopaths (280 Italian, 23 French and 82 British) were included in the data processing; the 38 excluded were physiotherapists and chiropractors. The most significative outcomes for the total sample were found to: years of working experience and knowledge of a palpatory test that allows to discriminate two dysfunctional anatomical structures was significant with a χ2=12.509 (p-value <0.006); 68.5% answered in the affirmative to this last question. It was found that less work experience is associated with knowledge of a palpatory test to discriminate two dysfunctional structures. The correlation between years of work experience and knowledge of the inhibitory test was explored with the result being statistically significant (p-value <0.001). 64.4% know and use the inhibitory test. 39.1% base the inhibitory test on tissue change.

Conclusions
The clinical practice of Italian and French professionals, makes possible to establish the hierarchy between two somatic dysfunctions with respect to English sample. The osteopaths reported a wider use of the tissue change parameters rather than pain reported by the patient. Furthermore, more than half of the sample-based their discriminatory test on the musculoskeletal and fascial systems. There is a vast knowledge of the inhibition test among osteopaths.
Hyperthyroidism in McCune–Albright Syndrome – a case report
Authors: Rosinha Patrícia , Ramalho Diogo , Rodrigues Orlando , Sousa Sérgio , Alves Cristina , Lopes Joana , Caetano Joana Serra , Mirante Alice 
Published: November 2022

Abstract

Objectives
We intend to describe a case of McCune-Albright Syndrome (MAS), a rare disease characterized by fibrous dysplasia (FD), cutaneous hyperpigmentation and hyperfunctioning endocrinopathies (HFE).

Case presentation
We report the case of a 13-year-old male child who presented with a café-au-lait macule in the lumbosacral region and disabling polyostotic FD, requiring several surgical interventions and bisphosphonates from the age of 3 years (Y) + 9 months (M) due to persistent and severe pain. Hyperthyroidism (HT) became apparent at 5 Y + 1 M with a T3/T4 ratio greater than 20. Treatment with anti-thyroid drugs (ATD) was carried out for 7 Y and there was a progressive improvement in pain complaints 8 M after starting ATD, allowing treatment with pamidronate to be discontinued. Total thyroidectomy was performed at 12 Y + 5 M.

Conclusions
This is a case of MAS-associated HT that reflects the deleterious effect of thyroid hormone excess on FD, reinforcing the need of having a low threshold for suspicion of HFE that may arise.