bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Plasmonic Sensor Based on D-Shaped Dual-Core Microchannel Photonic Crystal Fiber
Authors: Bing Pibin , Liu Qing , Wu Guifang , Yuan Sheng , Li Zhongyang , Yao Jianquan 
Published: January 2022

Abstract
In this paper, a dual-core microchannel-based fiber sensor is studied by using finite element method in the visible and near-infrared bands. Plasmonic material gold (Au) is deposited in microchannel to generate the surface plasmon resonance (SPR) effect, so that sensor can detect the change in RI of its surrounding analyte. Simulation results show that the maximum wavelength sensitivity and resolution are 33600nm/RIU and 2.97×10−6RIU for y polarization in the RI range of 1.33 to 1.44, respectively. The highest figure of merit (FOM) of the sensor is 961 for y polarization. In addition, we study the effects brought by the structural changes of the fiber sensor, and the results show that the design of “microchannel coating” dramatically improves the refractive index detection ability of the sensor. The D-shaped dual-core microchannel-based photonic crystal fiber sensor proposed in this paper has a simple structure, low manufacturing complexity, and high sensitivity. Combined with external sensing technology, this sensor has great application potential in the fields of biotechnology, medical diagnosis, and environmental protection.
Parent-Child Dyads with Greater Parenting Stress Exhibit Enhanced Inter-Brain Synchrony During Shared Play
Authors: Azhari Atiqah , Bizzego Andrea , Esposito Gianluca 
Published: January 2022

Abstract
Parent-child dyads who are mutually attuned to each other during social interactions display interpersonal synchrony that can be observed overtly, in the form of joint behaviours, and biologically, such as through the temporal coordination of brain signals called inter-brain synchrony. Joint play provides ample opportunities for parent-child dyads to engage in matching interactions which not just facilitate the formation of bonds but also alleviate parenting stress in caregivers. Despite the beneficial effects of play on parents and the parent-child relationship, no study has investigated the dyadic neural mechanism by which this occurs. The present functional Near-infrared Spectroscopy (fNIRS) study aimed to examine the association between parenting stress and inter-brain synchrony in the prefrontal cortex of 31 mother-child and 29 father-child dyads while they engaged in shared play for 10 minutes. Shared play was miro-analytically coded into joint (i.e., in-phase matching of dyadic behaviours) and non-joint (i.e., no matching of dyadic behaviours) segments. Inter-brain synchrony was computed using cross-correlations over 15 s, 20 s, 25 s, 30 s and 35 s fixed-length windows of joint and non-joint play segments. Analyses of Covariance revealed that dyads with more parenting stress exhibited greater inter-brain synchrony in the frontal left cluster of the prefrontal cortex, but only for the 35 s fixed-length window. This finding suggests that continuous and positive instances of joint play may disproportionately benefit dyads who reported greater parenting stress, entraining underlying brain activation patterns involved in social cognition. Mother-child dyads also showed greater inter-brain synchrony than father-child dyads, alluding to possible gender differences in the effect of play on dyads. Findings present evidence of a potential dyadic neural pathway by which play benefits the parent-child relationship.
Racial Disparities in Neutrophil Counts Among Patients with Metastatic Breast Cancer during Treatment with CDK4/6 Inhibitors
Authors: Weiner Ashley Brooke , Munoz-Arcos Laura , Alvarez Alvaro , Sparano Joseph A. , Anampa Jesus D. 
Published: January 2022

Abstract
Purpose: The three CDK4/6 inhibitors (CDK4/6i) approved for use in HR-positive/HER2-negative metastatic breast cancer (MBC), palbociclib, ribociclib, and abemaciclib, are generally well tolerated but their most common toxicity is neutropenia. Within the general population, neutropenia has been shown to be more common in individuals of African descent. The landmark CDK4/6i trials in MBC lacked racial diversity in their patient populations. We aimed to assess the toxicity profiles of CDK4/6i in a racially diverse population.Methods: We conducted a retrospective study at Montefiore Medical Center in patients with HR-positive/HER2-negative MBC prescribed CDK4/6i as first or subsequent lines of therapy between January 2015 and April 2020. Baseline characteristics and laboratory data at various treatment timepoints were collected. Results: A total of 182 patients were included in the final analysis. Baseline absolute neutrophil count (ANC) was lower in the Black vs. Non-Black cohort (p=0.001) but the change in ANC from baseline (Delta-ANC) was smaller in the Black vs. Non-Black cohort and the ANC at different treatment timepoints was similar between groups. There was no difference in the rate of infection or number of dose delays or reductions between Black and Non-Black cohorts. Conclusion: We analyzed toxicity profiles of 182 patients with HR-positive/HER2-negative MBC treated with CDK4/6i. Our population included 46% Black patients, who were found to have a lower baseline ANC but no increase in complications. Despite the lower baseline ANC seen in our Black cohort prior to starting CDK4/6i, treatment toxicities were similar between racial groups.
Examination of The Characteristics of Long-Term Survivors Among Patients With Gallbladder Cancer With Liver Metastasis Who Underwent Surgical Treatment: A Retrospective Multicenter Study (ACRoS1406)
Authors: Higuchi Ryota , Ono Hiroaki , Matsuyama Ryusei , Takemura Yusuke , Kobayashi Shinjiro , Otsubo Takehito , Abe Yuta , Endo Itaru , Tanabe Minoru , Yamamoto Masakazu 
Published: January 2022

Abstract
Background: Gallbladder cancer (GBC) with liver metastasis is considered unresectable. However, there have been infrequent reports of long-term survival in patients with GBC and liver metastases. Therefore, we examined the characteristics of long-term survivors of gallbladder cancer with liver metastasis.Methods: A retrospective multicenter study of 503 patients with GBC (mean age, 68.6 years; female, 52%) was performed. Although patients with pre-operatively diagnosed GBC and liver metastasis were generally excluded from resection, some cases identified during surgery were resected.Result: In patients with resected stage III/IV GBC (n = 228), the period 2007–2013 (vs. 2000–2006, hazard ratio 0.55), other type histology (vs. well/moderate histology, hazard ratio 2.34), ≥2 liver metastases (vs. one liver metastasis, hazard ratio 4.30), and positive margin resection (vs. complete resection with a negative margin, hazard ratio 1.57) were independent prognostic factors for overall survival, whereas one liver metastasis (vs. no liver metastasis) was not. The 5-year overall survival and median survival times in those with one liver metastasis with complete resection and a negative margin (40.9%, 28.3 months) were significantly better than those in patients with ≥2 liver metastases with complete resection and a negative margin (0%, 11.0 months, p = 0.025), and comparable to those in patients with liver metastasis with complete resection and a negative margin (37.0%, 33.0 months). According to the univariate analysis of resected patients with GBC and liver metastases (n=24), minor hepatectomy, less blood loss, less surgery time, papillary adenocarcinoma, T2, morbidity of Clavien–Dindo classification ≤ 2, and adjuvant chemotherapy were significantly associated with longer survival. Long-term survivors (n = 5) had a high frequency of T2 tumors (4/5), had small liver metastases near the gallbladder during or after surgery, underwent minor hepatectomy without post-operative complications, and received post-operative adjuvant chemotherapy.Conclusions: Although there is no surgical indication for GBC with liver metastasis diagnosed pre-operatively, minor hepatectomy and post-operative chemotherapy may be an option for selected patients with T2 GBC and liver metastasis identified during or after surgery who do not have other poor prognostic factors.
Anatomical Breast Imaging Derived Parameters Do Not Provide Incremental Information In Prediction of Nonvisualization of Sentinel Lymph Nodes On Lymphoscintigraphy
Authors: Chahid Youssef , Verberne Hein J. , Poel Edwin , Hendrikse N. Harry , Booij Jan 
Published: January 2022

Abstract
Background: Accurate sentinel lymph node (SLN) staging is essential for both prognosis and treatment in patients with breast cancer. However, the preoperative lymphoscintigraphy may fail to visualize the SLN. The aim of this retrospective study was to investigate whether parameters derived from anatomical breast imaging can predict SLN nonvisualization on lymphoscintigraphy. For this single-center retrospective study all data of mammography, breast magnetic resonance imaging (MRI), and lymphoscintigraphy of SLN procedures from January 2016 to April 2021 were collected and reviewed from the Amsterdam UMC electronic health records database.Results: A total of 758 breast cancer patients were included in this study. The SLN nonvisualization rate was 29.7% on lymphoscintigraphy. Multivariable analysis showed that age ≥ 70 years (P = 0.019; OR: 1.82; 95% CI: 1.10–3.01), BMI ≥ 30 kg/m2 (P = 0.031; OR: 1.59; 95% CI: 1.04–2.43), and nonpalpable tumors (P = 0.034; OR: 1.54; 95% CI: 1.03–2.04) were independent predictors of SLN nonvisualization. Differences in tumor size, Breast Imaging-Reporting and Data System (BI-RADS) classification, or breast density were not significantly associated with SLN nonvisualization.Conclusions: This study shows that, by using a multivariable analysis, risk factors for SLN nonvisualization in breast cancer patients during preoperative lymphoscintigraphy are age ≥70 years, BMI ≥30 kg/m2, and nonpalpable tumors. Parameters derived from mammography or breast MRI, however, are not useful to predict SLN nonvisualization on lymphoscintigraphy.
The Effect of Covid-19 Infection in Early Pregnancy on Hematological Parameters and Miscarriage Rate
Authors: Atak Zeliha , Ocakoglu Sakine Rahimli , Uyaniklar Ozlem Ozgun , Ustunyurt Emin 
Published: January 2022

Abstract
Purpose Based on the fact that Coronavirus Disease 2019 (Covid-19) is assosiated with many hemocytometric changes, in this clinical trial we aimed to investigate the effect of this underlying inflammatory process on the frequency of miscarriage.Methods This is a retrospective cohort study. Patients with laboratory-confirmed Covid-19 infection before the 20th gestational week were determined as the study group. Healthy pregnant women in their early pregnancy were determined as the control group. Hematological parameters of all patients included in the analysis were evaluated.ResultsA total of 176 pregnant women with confirmed Covid-19 infections were evaluated, of which 117 were included in the analysis. 117 healthy pregnant women were determined as the control group. There was no difference between the groups according to demographic characteristics. The median white blood cell (WBC) and lymphocyte levels were lower in patients with Covid-19 infection (p<0.001, p<0.001). The value of platelet/lymphocyte ratio (PLR) was higher in the group with Covid-19 infection (160.95 vs 132.42, p<0.001). It was also determined that the median plateletcrit level was lower in the group with Covid-19 infection (p<0.001). The miscarriage rate in the Covid -19 infection group and control group was 14.2% and 9.4%, respectively. (p=0.220).ConclusionCovid-19 infection presents with low lymphocyte count and plateletcrit values ​​in pregnant women, and an increase in PLR rates in relation to the severity of the disease is observed. Although not statistically significant, Covid-19 infection was associated with increased miscarriage rates in our study.
The Lateral Tarsal Strip Procedure: Reflections by a Specialist With 20 Years of Experience in a Tertiary Medical Center (Cross-sectional Study)
Authors: Kim Jonghyun , Kim Joohyun , Baek Sehyun 
Published: January 2022

Abstract
Introduction: Lateral tarsal strip (LTS) is a simple surgical technique that can correct eyelid malposition. Clinical indications vary from involutional entropion and ectropion, lower lid laxity, and lower lid retraction to punctal and paralytic ectropion. LTS mainly treats eyelid malposition by correcting horizontal laxity. Herein, we report the clinical indications for and effects of LTS.Methods: We retrospectively reviewed medical records of patients who underwent LTS by a single oculoplastic surgeon with eight years of experience performing the procedure at Korea University Guro Hospital.Results: We included 247 patients with 325 treated eyelids in the study. Involutional entropion was the most common indication, accounting for 69 patients (27.94%) and 88 eyelids (27.08%). The second most common indication was lower lid laxity (n=44 patients (17.81%) and 68 eyelids (20.92%)). Simultaneous surgery in addition to LTS was performed in 167 patients (67.6%) and 219 eyelids (67.4%); the most common was endoscopic dacryocystorhinostomy (DCR), which was performed in 50 patients (29.94%) and 80 eyelids (36.53%). Conclusion: LTS can be performed alone or simultaneously with oculoplastic procedures for various indications. Overcorrection with fixation above the canthal angle is useful to reduce recurrence. This study aims to explain the clinical importance of the LTS procedure.
Bacterial Communities Along Environmental Gradients in Tropical Soda Lakes
Authors: Pellegrinetti Thierry A. , Cotta Simone R. , Sarmento Hugo , Costa Juliana S. , Delbaje Endrews , Montes Celia R , Camargo Plinio B , Barbiero Laurent , Rezende-Filho Ary T , Fiore Marli Fatima 
Published: January 2022

Abstract
Soda lakes environment is known to be variable and can have distinct differences according to geographical location. In this study, we investigated the effect of different environmental conditions of six adjacent soda lakes on bacterial communities and their functioning using a metagenomic approach combined with flow cytometry and chemical analyses. Ordination analysis using flow cytometry and water chemistry data from two sampling periods (wet and dry) clustered soda lakes in three different profiles: eutrophic turbid (ET), oligotrophic turbid (OT), and clear vegetated oligotrophic (CVO). Analysis of bacterial community composition and functioning corroborated this ordination; the exception was one ET lake, that was similar to one OT lake during the wet season, indicating drastic shifts between seasons. Microbial abundance and diversity increased during the dry period, along with a considerable number of limnological variables, all indicative of a strong effect of the precipitation-evaporation balance in these systems. Cyanobacteria were linked to high electric conductivity, pH, and nutrient availability, whereas Actinobacteria, Alphaproteobacteria, and Betaproteobacteria were correlated with landscape morphology variability (surface water, surface perimeter, and lake volume) and less stressed lake conditions. Stress response metabolism was overrepresented in ET and OT lakes and underrepresented in CVO lakes. Altogether, this study illustrated the sensitivity of tropical soda lakes to climate change, as slight changes in hydrological regimes might produce drastic shifts in community diversity.
Impact Forces and Energy of Flow-like Landslides Against Protection Barriers: a New MPM-validated Empirical Formulation
Authors: Perna Angela Di , Cuomo Sabatino , Martinelli Mario 
Published: January 2022

Abstract
Full understanding the interaction mechanisms between flow-like landslides and the impacted protection structures is an open issue. In fact, while researchers have used several approaches, from experimental to numerical, it is true that the adequate assessment of the hydromechanical behaviour of the landslide body requires both a multiphase and large deformation approach.This paper firstly proposes a conceptual framework for a specific type of protection structure, namely a rigid barrier fixed to the base ground. Two different approaches are proposed: i) an advanced hydro-mechanical numerical model based on Material Point Method is tested in simulating the whole complex landslide-structure-interaction mechanism(s), ii) a more simplified empirical model is casted to estimate the impact force and the time evolution of kinetic energy. The calibration and validation of the empirical formulation are pursued, respectively, based on the MPM numerical results, and referring to a large dataset of field evidence for the peak impact pressure. Finally, the performance of the newly proposed empirical method is compared to the methods available in the literature and its advantages are outlined.
An Anthranilate Derivative Inhibits Glutamate Release and Glutamate Excitotoxicity in Rats
Authors: Lu Cheng-Wei , Lin Chen-Yung , Hsieh Pei-Wen , Chiu Kuan-Ming , Lee Ming-Yi , Lin Tzu-Yu , Wang Su-Jane 
Published: January 2022

Abstract
The neurotransmitter glutamate plays an essential role in excitatory neurotransmission; however, excessive amounts of glutamate lead to excitotoxicity, which is the most common pathogenic feature of numerous brain disorders. This study aimed to investigate the role of butyl 2-[2-(2-fluorophenyl)acetamido]benzoate (HFP034), a synthesized anthranilate derivative, in the central glutamatergic system. We used rat cerebrocortical synaptosomes to examine the effect of HFP034 on glutamate release. In addition, we used a rat model of kainic acid (KA)-induced glutamate excitotoxicity to evaluate the neuroprotective potential of HFP034. We showed that HFP034 inhibits 4-aminopyridine (4-AP)-induced glutamate release from synaptosomes, and this inhibition was absent in the absence of extracellular calcium. HFP034-mediated inhibition of glutamate release was associated with decreased 4-AP-evoked Ca2+ level elevation and had no effect on synaptosomal membrane potential. The inhibitory effect of HFP034 on evoked glutamate release was suppressed by blocking P/Q-type Ca2+ channels and protein kinase C (PKC). Furthermore, HFP034 inhibited the phosphorylation of PKC and its substrate, myristoylated alanine‐rich C kinase substrate (MARCKS), in synaptosomes. We also observed that HFP034 pretreatment reduced neuronal death, glutamate concentration, glial activation, and the levels of endoplasmic reticulum stress-related proteins, calpains, glucose-regulated protein 78 (GRP 78), C/EBP homologous protein (CHOP), and caspase-12 in the hippocampus of KA-injected rats. We conclude that HFP034 is a neuroprotective agent that prevents glutamate excitotoxicity, and we suggest that this effect involves inhibition of presynaptic glutamate release through the suppression of P/Q‐type Ca2+ channels and PKC/MARCKS pathways.
DIRAS2 Contributes to Radiation Resistance of Renal Cell Carcinoma Via Autophagy Induction and MKK4-JNK1 Pathway Activation
Authors: Cai Chengfeng , He Ying , Yue Dong , Tian Jun , Guo Ning 
Published: January 2022

Abstract
Radiation resistance has been regarded as a main obstacle to improve the definitive treatment of renal cell carcinoma (RCC), of which clear cell RCC (ccRCC) is the most common histological type. However, the molecular mechanism underlying the radiation resistance remains largely unclear. In this study, we investigated the effect of DIRAS2 on the response to ionizing radiation (IR) in human ccRCC cells. Here, we found the expression level of DIRAS2 was significantly upregulated in human ccRCC tissues using the Oncomine platform and the Cancer Genome Atlas (TCGA) database, which was further validated by immunohistochemistry. Overexpression of DIRAS2 promoted radiation resistance of ccRCC cells based on clonogenic survival assay and enhanced the levels of radiation induced-autophagy. Moreover, inhibition of autophagy by chloroquine (CQ) pre-treatment largely eliminated the effect of DIRAS2 overexpression on radiation-resistance. Finally, molecular mechanism investigation showed that overexpression of DIRAS2 upregulated the activity of mitogen-activated protein kinase (MAPK) kinase 4 (MKK4)- c-Jun NH2-terminal kinase 1 (JNK1)-Bcl-2 pathway in response to IR. Taken together, these results indicate that DIRAS2 may confer radiation resistance on human RCC via autophagy induction through MKK4-JNK1-Bcl-2 signaling pathway.
Physical-chemical and Biological Properties of Novel Resin-based Composites for Dental Applications
Authors: Buchwald Zuzanna , Sandomierski Mariusz , Smułek Wojciech , Ratajczak Maria , Patalas Adam , Kaczorek Ewa , Voelkel Adam 
Published: January 2022

Abstract
Insufficient mechanical properties of hydroxyapatite -based composites prompted the search for new and effective solutions for dental applications. To improve the mechanical properties without losing the remineralization potential, the use of hybrid fillers was proposed. The first of them was based on the formation of hydroxyapatite (HA) layer on the surface of SYLOID®244 silica. The second of the investigated fillers was created by simultaneous synthesis of nanoparticles from precursors of HA and silica. The obtained fillers were extensively characterized by spectral methods including X-ray Diffractometry (XRD), Fourier-Transform Infrared Spectroscopy (FT-IR), and X-ray fluorescence (XRF), as well as by Scanning Electron Microscopy (SEM)/Energy Dispersive Spectroscopy (EDS). Tests using probiotic microorganisms were an important part of the analysis, indicating that there was no potential interaction of the materials with microflora. The tests of degree of conversion, depth of cure, opacity, sorption, solubility, flexural and compressive strength, and the remineralizing potential also showed that the composites with nano-sized silica/HA showed better mechanical properties than the composites with HA alone or commercial silica and at the same time the remineralization remained at the desired level. Thus, the proposed composite has a high application potential in the creation of implants and dental materials.
Anticancer, Antioxidant Activities and Molecular Docking Study of Thiazolidine -4-one and Thiadiazol Derivatives
Authors: Alsalim Tahseen Abdul qader , Nasir Noor M. , El-Arabey Amr Ahmed , Abdalla Mohnad 
Published: January 2022

Abstract
Liver cancer accounts for a major portion of the global cancer burden. In many nations, the prevalence of this condition has risen in recent decades. New series of thaiazolidinones and thaiadiazolidine have been designed, synthesized, and evaluated for potential antioxidant and antihepatocarcinogenic activity. The antioxidant activity of synthesized compounds was evaluated using a DPPH assay. Furthermore, we examined the compounds against HepG2 cells using MTT assay, flow cytometry analysis through the cell cycle, reactive oxygen species, and apoptosis. The result showed that compound 6b has the highest antioxidant activity with IC50 =60.614±0.739 µM. The anticancer activity showed that compounds 5 and 6b have significant toxicity against liver cancer cells HepG2, IC50 values (9.082 and 4.712) µM, respectively. Flow cytometry experiments revealed that compound 5 arrested HepG2 cells in the S process, while compound 6b arrested HepG2 cells in the G1. Compound 6b had a greater reduction in reactive oxygen species and late apoptosis than compound 5. Substantially, compound 5 had affinity energies of -7.6 and -8.5 for Akt and CDK4 proteins, respectively, but compound 6b had affinity energies of -7.8 and -10.1 for Akt1 and CDK4 proteins, respectively. Consequently, compound 6b had lower binding energies than compound 5. In this work, we used multiple bioinformatics methods to shed light on the prospective therapeutic use of these series as novel candidates to target immune cells in the tumor microenvironment of hepatocellular carcinomas such as CD8+ T cells, endothelial cells, and hematopoietic stem cells. The results of antioxidant, anticancer, molecular docking studies, and bioinformatic analysis showed that compound 6b has a potential impact and could be developed for drug discovery with further research.