bluuebunny/crossref_metadata_2025_split huggingface dataset:
Synthesis, Characterization and Evaluation of 5α, 6β-Dihalo Androsterone
Derivatives as 5α-Reductase Inhibitors
Authors: Dhingra Neelima , Sharma Akansha , Rana Priyanka , Arora Poonam , Kaur Tanzeer 
Published: May 2022

Background and Objective:
Testosterone under the influence of 5α-reductase enzyme gets converted to dihydrotestosterone and high levels are found to be causative for androgen dependent disease like benign prostatic hyperplasia. Thus, 5α-reductase has been recognised as an important target for discovering new drugs against Benign Prostatic Hyperplasia and Prostate Cancer.

Methods:
In the present study, a series of 5α, 6β-Dichloro-17-Oxoandrostan-3β-yl esters (7a-7f) were synthesized and characterized by analytical and spectroscopic methods. The compounds were evaluated for their 5α-reductase inhibitory activity in-vivo by their effect on serum androgen level.

Results:
The target compounds (7a-7f) showed increased anti-androgenic activity as compared to finasteride and control, which implies that the target compounds are effective in inhibiting 5α-reductase. Particularly, compound 7b showing highest inhibitory activity and noteworthy D-Score was further sorted by performing solubility and dissolution studies. Results of these studies when compared with finasteride showed increased solubility and dissolution of target compound 7b.

Conclusion:
These results demonstrated that enhancement of activity by the presence of electronegative group at position 3 of the steroidal nucleus makes 7b a lead compound for further exploration and optimal formulation.
M-CAMPTM: A Cloud-based Web Platform with a Novel Approach for
Species-level Classification of 16S rRNA Microbiome Sequences
Authors: Daniely Michal , Liu Yang , Schriefer Andrew E. , Kumar Brajendra , Zolty Avihai , Didier Adam , Nirmal M.G.  , Greeshma G.T.  , Nadiv Nofar , Perez Michael , Preetam R.  , Mahankuda Santosh Kumar , Kumar Pankaj , Tenney Aaron , Bourner Maureen , Lezer Shira , Zhong Fei 
Published: May 2022

Background:
The M-CAMPTM (Microbiome Computational Analysis for Multi-omic Profiling) Cloud Platform was designed to provide users with an easy-to-use web interface to access best in class microbiome analysis tools. This interface allows bench scientists to conduct bioinformatic analysis on their samples and then download publication-ready graphics and reports.

Objective:
In this study we aim to describe the M-CAMPTM platform and demonstrate that the taxonomic classification is more accurate than previously described methods on a wide range of microbiome samples.

Methods:
The core pipeline of the platform is the 16S-seq taxonomic classification algorithm which provides species-level classification of Illumina 16s sequencing. This algorithm uses a novel approach combining alignment and kmer based taxonomic classification methodologies to produce a highly accurate and comprehensive profile. Additionally, a comprehensive proprietary database combining reference sequences from multiple sources was curated and contains 18056 unique V3-V4 sequences covering 11527 species.

Results and Discussion:
The M-CAMPTM 16S taxonomic classification algorithm was evaluated on 52 sequencing samples from both public and in-house standard sample mixtures with known fractions. The same evaluation process was also performed on 5 well-known 16S taxonomic classification algorithms including Qiime2, Kraken2, Mapseq, Idtaxa and Spingo using the same dataset. Results have been discussed in term of evaluation metrics and classified taxonomic levels.

Conclusion:
Compared to current popular public classification algorithms, M-CAMPTM 16S taxonomic classification algorithm provides the most accurate species-level classification of 16S rRNA sequencing data.
Amivantamab: A New Hope in Targeting Non-small Cell Lung Cancer
Authors: Chawla Pooja A. , Billowria Koushal , Das Gupta Ghanshyam 
Published: May 2022

Background:
Amivantamab was approved on May 21st, 2021, by United States food and drug administration
with the brand name Rybervant, used particularly for adult patients with exon20 insertion of epithelial growth
factor receptor with locally advanced metastatic non-small cell lung cancer.

Objective:
In this review, we explain the non-small cell lung cancer and molecular distinctions between non-small cell
lung cancer and small cell lung cancer. We also conclude numerous components of non-small cell lung cancer, which
include signs and symptoms of Amivantamab in inhibiting the cancer cell growth, various clinical trials on Amivantamab,
adverse effects, and the contraindications of Amivantamab.

Methods:
A comprehensive literature search was conducted in the relevant databases like ScienceDirect, PubMed,
ResearchGate, and Google Scholar to identify studies.

Conclusion:
Amivantamab is a new bispecific antibody that targets non-small cell lung cancer through two different
pathways, i.e., by binding to epithelial growth factor receptor and mesenchymal epithelial transition factor. Amivantamab
gets tightly bound to Fcγ3R, and thus, mediates the macrophage and NK-cell for the killing of cancer cells.
Biological treatment of Amivantamab shows effectiveness against the epithelial growth factor receptor Exon20 insertions
according to the preclinical data of the animal model.
Diagnostic Value of Potential MicroRNAs in CRC: A Meta-Analysis
Authors: Fathi Sofia , Guessous Fadila , Karkouri Mehdi 
Published: May 2022

Background:
MicroRNAs (miRNAs) are small noncoding RNA molecules involved in the post-transcriptional regulation of genes. Deregulated expression of miRNAs is involved in different pathogenic mechanisms, particularly colorectal cancer (CRC) carcinogenesis. Due to their stability and accessibility, circulating miRNAs represent a new family of biomarkers with great potential. Therefore, certain miRNAs can be used as diagnostic biomarkers in CRC.

Objective:
This systematic analysis aimed to explore the individual efficacy of the most investigated blood-based miRNAs for CRC diagnosis, namely miR-21, miR-29a and miR-92a.

Methods:
Articles were retrieved from databases such as PubMed and Google Scholar, and studies designed to evaluate the diagnostic value of microRNAs in CRC were then selected. We subsequently explored the diagnostic accuracy of each miRNA using parameters such as (SE, SPE, PLR, NLR). The meta-analysis was performed using the Review Manager (Revman) 5.4 software and the Meta Disc software.

Results:
Our results suggested that serum miR-21 levels showed great potential as a diagnostic molecular marker. The overall pooled results for sensitivity, specificity, area under the curve (AUC), PLR, and NLR were 78%, 91%, 0.9519, 8.12 and 0.17 respectively.

Conclusion:
miRNAs have become increasingly important in the diagnosis of CRC. Based on these findings, circulating miR-21 levels may have a potential value for early detection and might be used as a novel diagnostic biomarker for CRC.
Potential of Polyphenolic Nutraceuticals in the Management of Glioblastoma
Multiforme
Authors: Raysing Swati Devendra , Gorle Ashish Prakash 
Published: May 2022

Abstract:
Glioblastoma Multiforme (GBM) is a malignant central nervous system tumor. GBM is produced
by aggressive proliferation of cells and invasion of normal brain tissue. The current conventional
therapies for GBM include surgery, chemotherapy, and radiation therapies which are challenging and
produce adverse effects. Thus, polyphenolic nutraceuticals are effective natural compounds for preventing
and treating GBM due to their chemoprotective activity. Polyphenols are bioactive, non-nutrient plant
chemicals structurally sub-divided into 5 groups; among these groups, phenolics and flavonoids are
widely studied as they have lesser side effects and a more significant potential to pass the Blood-Brain
Barrier (BBB). These polyphenolic nutraceuticals have the potential to advance current GBM treatment
options. This review throws light on the anti-cancer efficacy of major polyphenol classes (Phenolic acid,
Flavonoids, Stilbenes, Lignans) and discusses their prospective mechanisms of action in GBM.
Perspectives of Patients and Therapists on Social Media and Digital Data Use in Mental Health Therapy: Thematic Analysis
Authors: Southwick Lauren , Suh Rebecca , Kranzler Elissa , Bradley Megan , Merchant Raina M 
Published: May 2022

Background
Incorporating insights from social media into the patient-provider encounter is increasingly being explored in health care settings. Less is known about the utility of these data in mental health therapy.

Objective
This study aims to prospectively investigate and characterize how social media and digital data are used in mental health therapy from both the patient and mental health therapist perspective.

Methods
Patients enrolled in mental health therapy and mental health therapists were interviewed using a semistructured interview guide. All interviews were transcribed and coded using a deductive framework analysis. Themes and subthemes were identified. Participants completed a sociodemographic survey, while mental health therapists also completed a behavioral norms and elicitation survey.

Results
Seventeen participants, that is, 8 (48%) mental health therapists and 9 (52%) patients were interviewed. Overall, participants identified 4 themes and 9 subthemes. Themes were current data collection practices, social media and digital data in therapy, advantages of social media and digital data in therapy, and disadvantages of social media and digital data in therapy. Most subthemes were related to the advantages and disadvantages of incorporating digital data in mental health therapy. Advantage subthemes included convenience, objective, builds rapport, and user-friendliness while disadvantage subthemes were nonreflective, ethically ambiguous, and nongeneralizable. The mental health therapists' behavioral norms and elicitation survey found that injunctive and descriptive normative beliefs mapped onto 2 advantage subthemes: convenience and objectivity.

Conclusions
This qualitative pilot study established the advantages and disadvantages of social media and digital data use in mental health therapy. Patients and therapists highlighted similar concerns and uses. This study indicated that overall, both patients and therapists are interested in and are comfortable to use and discuss social media and digital data in mental health therapy.
Estimating Cardiorespiratory Fitness Without Exercise Testing or Physical Activity Status in Healthy Adults: Regression Model Development and Validation
Authors: Sloan Robert , Visentini-Scarzanella Marco , Sawada Susumu , Sui Xuemei , Myers Jonathan 
Published: May 2022

Background
Low cardiorespiratory fitness (CRF) is an independent predictor of morbidity and mortality. Most health care settings use some type of electronic health record (EHR) system. However, many EHRs do not have CRF or physical activity data collected, thereby limiting the types of investigations and analyses that can be done.

Objective
This study aims to develop a nonexercise equation to estimate and classify CRF (in metabolic equivalent tasks) using variables commonly available in EHRs.

Methods
Participants were 42,676 healthy adults (female participants: n=9146, 21.4%) from the Aerobics Center Longitudinal Study examined from 1974 to 2005. The nonexercise estimated CRF was based on sex, age, measured BMI, measured resting heart rate, measured resting blood pressure, and smoking status. A maximal treadmill test measured CRF.

Results
After conducting nonlinear feature augmentation, separate linear regression models were used for male and female participants to calculate correlation and regression coefficients. Cross-classification of actual and estimated CRF was performed using low CRF categories (lowest quintile, lowest quartile, and lowest tertile). The multiple correlation coefficient (R) was 0.70 (mean deviation 1.33) for male participants and 0.65 (mean deviation 1.23) for female participants. The models explained 48.4% (SE estimate 1.70) and 41.9% (SE estimate 1.56) of the variance in CRF for male and female participants, respectively. Correct category classification for low CRF (lowest tertile) was found in 77.2% (n=25,885) of male participants and 74.9% (n=6,850) of female participants.

Conclusions
The regression models developed in this study provided useful estimation and classification of CRF in a large population of male and female participants. The models may provide a practical method for estimating CRF derived from EHRs for population health research.
¿Es necesaria la filosofía en las escuelas? Percepción de docentes y estudiantes de escuelas públicas
Authors: Gutiérrez Rojas Eliana , Morón Castro Camilo 
Published: May 2022

Este estudio se centra en analizar la situación de la enseñanza de la filosofía en las aulas de educación media en la ciudad de Barranquilla (Atlántico, Colombia), teniendo en cuenta la percepción de docentes y alumnos en el año 2021. La muestra constó de 8 docentes y 8 estudiantes que fueron entrevistados por medio de un guion de preguntas validado por expertos. Para el análisis de la información, se siguió una metodología de diseño fenomenológico y enfoque cualitativo. Los hallazgos muestran una serie de obstáculos en la formación derivados del desconocimiento de estrategias didácticas en filosofía, la conservación del paradigma educativo histórico-filosófico y doctrinal y el perfil de los encargados de la asignatura de filosofía, además de estar alejada de los lineamientos de las autoridades educativas gubernamentales fundamentados en la enseñanza por problemas.
Riwayat Qalun dan Warsy pada Qiraat Nafi’ dalam Surah Al-Shaff
Authors: Suarni Suarni , Saiful Bahari Ahmad Sufian Bin 
Published: May 2022

The riwayah of Qalun and Warsy is a way of reading the Qur’an that is widely circulated in Indonesian society with various differences. Unfortunately, people are not very familiar with the various ways of reading the Qur'an, even if they hear the reading of the Qur'an that is different from their habit, they will judge it as something foreign. From this phenomenon, it is necessary to explain to the public the procedures for reading the Qur'an from the riwayah of Qalun and Warsy, so that there will be no suspicion when they hear a different way of reading the Qur'an. The results show that there are many differences in the Qalun and Warsy qirãat contained in the ash-Shaff surah, there are 12 differences in terms of the manhaj qiraat. 4 differences in the (Ũshul) Qalun qiraat section and 10 differences in the Warsy qirat (Ushul) section. There are also 2 differences in the (Farsy al-huruf) section of the Qalun qiraat and there is 1 difference in the (Farsy al-huruf) section of the Warsy qiraat. The author also found 40 places in the whole of Surah al-Shaff which have different readings, for Qalun there are 24 different places and Warsy has 28 different places, so that the Qur'an cannot be read with only one version of qiraat. Riwayat Qalun dan Warsy merupakan cara baca al-Qur’an yang banyak beredar dalam masyarakat Indonesia dengan berbagai perbedaan yang ada. Sayangnya masyarakat tidak begitu familiar dengan beragam cara baca al-Qur’an, bahkan jika mereka mendengar bacaan al-Qur’an yang berbeda dari kebiasaan, akan menilai hal itu sebagai sesuatu yang asing. Dari fenomena ini perlu dijelaskan kepada masyarakat tata cara bacaan al-Qur’an riwayat Qalun dan Warsy, sehingga tidak akan muncul rasa curiga ketika mendengar car abaca al-Qur’an yang berbeda. Hasil penelitian menunjukkan bahwa banyak perbedaan qiraat Qalun dan Warsy yang terdapat dalam surah ash-Shaff, terdapat 12 perbedaan dari segi manhaj qiraat. 4 perbedaan pada bagian (Ushul) qirãat Qalun dan 10 perbedaan pada bagian (Ushul) qirãat Warsy. Terdapat juga 2 perbedaan pada bagian (Farsy al-huruf) qirãat Qalun dan ada 1 perbedaan pada bagian (Farsy al-huruf) qiraat Warsy. Penulis juga enemukan 40 tempat pada keseluruhan surah ash-Shaff yang berlaku perbedaan bacaan, bagi Qalun mempunyai 24 tempat perbedaan dan Warsy mempunyai 28 tempat perbedaan, sehingga al-Qur’an tidak dapat dibaca dengan satu versi qirãat saja.
Lafaz Sa’ala dalam Al-Qur’an
Authors: Nurullah Nurullah , Husna Siti 
Published: May 2022

The Qur'an uses a lot of vocabularies that appear to be synonymous at birth, but when examined carefully it turns out that each vocabulary has its own connotation that does not exist in other pronunciations that are considered synonymous with it. As stated by Abi Isba' quoted by Nasiruddin Baidan that the beauty of the language of the Koran is classified into two major groups, namely the beauty of speech and the beauty of meaning. One of them is lafaz sa'ala, the lafaz is one of the lafaz that is repeated a lot in the Qur'an, 129 times, both in the same form and in different forms. This study is based on library research, besides that, the author examines these verses using the maudhu'i interpretation framework. Lafaz sa'ala is found in the Qur'an 129 times in 118 verses in 47 surah with 55 different forms of lafaz sa'ala. The whole lafaz sa'ala which means a question is repeated 73 times, whether there are two pronunciations in one verse or not. As for the meaning of asking to be called 49 times, while the meaning of asking is called 5 times and the meaning of rebuttal, speaking is only mentioned once. Alquran banyak memakai kosa kata yang pada lahirnya tampak bersinonim, namun bila diteliti secara cermat ternyata masing-masing kosa kata itu mempunyai konotasi sendiri-sendiri yang tidak ada pada lafal lain yang dianggap bersinonim dengannya. Sebagaimana pernyataan Abi Isba’ yang dikutip oleh Nasiruddin Baidan bahwa keindahan bahasa Alquran itu diklasifkasikan menjadi dua kelompok besar yaitu keindahan lafaz dan keindahan makna. Salah satunya adalah lafaz sa’ala, lafaz tersebut merupakan salah satu lafaz yang banyak diulang dalam Alquran, sebanyak 129 kali, baik dalam bentuk yang sama maupun dalam bentuk yang berbeda. Kajian ini berbasis kajian kepustakaan (library research), selain itu penulis mengkaji ayat-ayat tersebut dengan menggunakan kerangka kerja tafsir maudhu’i. Lafaz sa’ala ditemukan di dalam Alquran sebanyak 129 kali dalam 118 ayat di dalam 47 surah dengan 55 bentuk lafaz sa’ala yang berbeda-beda. Keseluruhan lafaz sa’ala yang bermakna tanya di ulang sebanyak 73 kali baik yang terdapat dua lafaz dalam satu ayat maupun tidak. Adapun yang makna nya minta di sebut sebanyak 49 kali, sedangkan yang bermakna memohon disebut sebanyak 5 kali dan yang bermakna bantahan, bercakap hanya disebut sekali saja.
STUDI KEKUATAN KOLOM PROFIL C DENGAN COR BETON PENGISI DAN PERKUATAN TRANSVERSAL
Authors: Budi Laksono Damar , Yoso Wigroho Haryanto 
Published: May 2022

Baja adalah salah satu bahan yang penting dalam dunia konstruksi. Profil yang digunakan sebagai struktur utama (kolom dan balok) dalam suatu bangunan pada umumnya memakai profil hasil bentukan panas. Profil hasil bentukan dingin biasanya hanya digunakan sebagai gording dan rangka atap. Pada penelitian ini dicoba kolom profil C (hasil bentukan dingin) yang diberi perkuatan tulangan transversal dan dicor beton pengisi yang dibebani sentris pada pusat sumbu kolom. Penelitian ini menggunakan profil kanal C yang akan digunakan sebagai kolom dengan diberi cor beton pengisi dan diberi perkuatan transversal. Panjang kolom profil kanal C 750 mm sebagai kolom pendek dan 1500 mm sebagai kolom panjang. Dimensi profil yang digunakan adalah tinggi (h) = 92,8 mm; lebar (b) = 34,0333 mm; lebar sayap (a) = 8,2667 mm dan tebal (t) = 1,8 mm. Benda uji sejumlah 16 buah dimana terbagi menjadi 2 kelompok yaitu benda uji yang diberi cor beton pengisi dan yang tidak diberi diberi cor beton pengisi. Setiap kelompok tersebut terdiri dari 4 buah benda uji kolom pendek dan 4 buah benda uji kolom panjang. Variasi perkuatan transversal pada masing-masing benda uji tersebut berbeda-beda yaitu 50 mm, 75 mm dan 100 mm. Data yang diperoleh berupa data lendutan kolom kesamping dan beban sentris yang dicapai oleh kolom.	Penambahan cor beton meningkatkan kekuatan pada kolom pendek rata-rata sebesar 185,7%. Sedangkan pada kolom panjang rata-rata sebesar 148%. Defleksi maksimum terbesar kolom pendek tanpa cor beton pengisi sebesar 7,4 mm pada perkuatan 75 mm. Sedangkan pada kolom panjang tanpa cor beton pengisi sebesar 19,05 mm pada perkuatan 75 mm. Pada kolom pendek dengan cor beton pengisi defleksi maksimum tersebar terjadi pada perkuatan 50 mm sebesar 11,36 mm. Pada kolom panjang terjadi pada perkuatan 75 mm sebesar 27,1 mm. Pemberian cor beton pengisi terbukti dapat mencegah tekuk lokal yang terjadi karena dengan pemberian cor beton pengisi meningkatkan beban yang diterimanya hingga dapat melalui beban teoritisnya.
ANALISA KEKUATAN TARIK BESI BETON STRUKTUR BETON JEMBATAN WAIHATTU (PERHITUNGAN MANUAL-MINITAB.13)
Authors: Nanse H Pattiasina Steanly R.R Pattiselanno 
Published: May 2022

Tujuan penelitian adalah menganalisa lanjut hasil uji kekuatan tarik besi beton untuk tulangan beton jembatan melalui perbandingan hasil perhitungan manual dengan program minitab versi 13 untuk tingkat kepercayaan 95% dan 99%. Perbandingan hasil yang dilakukan melalui pendekatan tahapan perhitungan manual adalah menghitung mean sampel, deviasi standar sampel dan estimasi interval mean populasi, serta tahapan Minitab Versi 13 adalah uji normalitas dan perhitungan cepat tingkat kepercayaan 95% dan 99%. Penelitian dilakukan menggunakan prosedur jumlah sampel kecil (n<30), untuk sampel berdiameter (Ø) 10 mm, 16 mm, 19 mm dan 22 mm. Berdasarkan teknik analisa dan hasilnya, terdapat perbedaan besaran kekuatan tarik maksimum dari benda uji melalui penggunaan metode estimasi titik dan metode estimasi interval, sebagai berikut besaran perbedaan untuk interval kepercayaan ci = 95%, berkisar antara 0,001% s/d 0,239%, besaran perbedaan untuk interval kepercayaan ci = 99% berkisar antara 0,002% s/d 0,550% dan perbedaan besaran tegangan tarik antara daerah interval kepercayaan ci = 99% dan ci= 95% berkisar antara 0,001% s/d 0,315%.
PERMODELAN KOEFISIEN GELOMBANG TRANSMISI PADA PEMECAH GELOMBANG KANTONG PASIR TIPE TENGGELAM
Authors: Fatnanta Ferry 
Published: May 2022

Terdapat beberapa kondisi dan permasalahan pada teknik pantai yang tidak dapat diselesaikan dengan analisa matematika. Salah satu cara mengatasi permasalahan tersebut dengan penggunaan perumusan empiris. Model fisik merupakan metoda untuk memahami karakter hidrodinamis. Hubungan antara gelombang transmisi dan variabel pengujian dapat dimodelkan secara empiris. Untuk mewujudkan model tersebut diperlukan suatu alat (tool). Sesuai dengan karakter hubungan gelombang transmisi terhadap struktur pemecah gelombang kantong pasir, pada penelitian ini digunakan analisa regresi sebagai tool. Pada pemecah gelombang kantong pasir, nilai Dn50 relatif konstan, sehingga variabel tersebut tidak dapat dijadikan variabel pengujian. maka bentuk dan susunan kantong, lebar puncak, kemiringan susunan dan freeboard merupakan parameter yang dapat dijadikan sebagai variabel pengujian. Hasil uji statistik menunjukkan bahwa ç - 1÷ model tak linear lnæ 1 öè Kt ømerupakan model yang cocok untuk menggambarkan karaktergelombang transmisi pada pemecah gelombang kantong pasir tipe tenggelam.