bluuebunny/crossref_metadata_2025_split huggingface dataset:
Creating a creative state of mind: Promoting creativity through proactive vitality management and mindfulness
Authors: Op den Kamp Emma M. , Tims Maria , Bakker Arnold B. , Demerouti Evangelia 
Published: May 2022

AbstractMost research on employee creativity has been focused on relatively distal antecedents, such as personality or job characteristics, which has resulted in top‐down organizational approaches to promote employee creativity. However, such approaches overlook the self‐regulating potential of employees and may not explain intraindividual fluctuations in creativity. In the present research, we build on proactive motivation theory to examine how employees may promote their own creativity on a daily basis through the use of proactive vitality management (PVM). To better understand the PVM‐creativity link, we zoom in on this process by examining the role of mindfulness as an underlying mechanism. In two daily diary studies, employees from the United States (N = 133 persons, n = 521 data points) and the creative industry in Germany (N = 62 persons, n = 232 data points) reported on their use of PVM and states of mindfulness for five consecutive workdays. Additionally, participants completed a daily creativity test (brainstorming task) in Study 1, whereas supervisors rated participants' daily creative work performance in Study 2. In both studies, multilevel analyses showed that daily PVM was positively related to creative performance through daily mindfulness, supporting our hypotheses. These replicated findings suggest that individuals may bring themselves in a cognitive, creative state of mind on a daily basis, emphasizing the importance of proactive behavior in the creative process.
The earliest metal in western Tibet: Evidence from the Gepa Serul cemetery
Authors: Cao Kun , Zhangsun Yingzi , Xian Yiheng , Yu Chun , Shargan Wangdue 
Published: May 2022

AbstractThe earliest copperwares excavated in western Tibet to date were found in the Gepa Serul cemetery in Zanda county, Ngari prefecture, Tibet, China, which can be dated to c.3600–3000 bp. This significant archaeological discovery provides valuable materials for the study of early metallurgy in prehistoric Tibet. This research applies scientific methods involving scanning electron microscopy with energy‐dispersive spectroscopy (SEM‐EDS), X‐ray fluorescence (XRF), optical microscopy (OM) and multicollector inductively coupled plasma mass spectrometry (MC‐ICP‐MS) to carry out analyses on the components, microstructures and Pb isotope ratios of Gepa Serul Phase I copperwares. The results show that their alloy types contain both pure copper and arsenic copper, the latter of which has not previously been recovered from archaeological contexts in Tibet. These artefacts were produced primarily by forging, supplemented by casting. Lead isotope analysis (LIA) reveals that the copper ores used most likely came from multiple sources, some of which may be local to the Tibet area. The Pb isotope values of the copperwares from Gepa Serul Phase I are very similar to those from the Sam Dzong cemetery in Nepal, implying that the metal resources used by the two sites are likely to be correlated.
Anticipatory state identity: Understanding the Finnish state's approach to the Arctic
Authors: Ferdoush Md Azmeary , Väätänen Vesa 
Published: May 2022

AbstractThis paper is an intervention on the understanding of state identity in relation to (anticipatory) changes that have occurred, are taking place, and are expected to happen in the Arctic. Focusing specifically on the Finnish state's approach to the Arctic, we offer the concept of ‘anticipatory state identity’ in order to comprehend the role of ‘anticipation’ in developing and projecting a ‘state identity.’ In so doing, we argue that what drives Finland's vision to project itself to be(come) an ‘Arctic state’ is fuelled not only by placing a firm foothold in a region of increasing geopolitical importance but also by a consensus among wide‐ranging actors in prioritising Finnish Arcticness in its foreign policy. As such, we first shed light on the concept of ‘anticipatory state identity.’ Then we discuss the global and regional shifts that eventually drove Finland to focus on its Arcticness. Third, we delve into the components and enactments through which Finland projects its Arctic identity. Finally, we conclude that anticipatory state identity bridges the gap between a state's imagination of itself in the future and how such imaginations are materialised and embedded within state policies through a repetitive deployment of narratives and discourses by numerous practitioners in the present. Accordingly, the applicability of the concept moves beyond the Arctic context as it enables reading of (re)forming state identity in line with its anticipatory vision.
Cities of neurodiversity: New directions for an urban geography of neurodiversity
Authors: Kenna Therese 
Published: May 2022

AbstractThis paper calls for a research agenda that attends to neurodiversity in the city. I argue for the need to better understand the variety of lived urban experiences of those who identify as neurodiverse and for these voices to be integrated into urban planning and policy. This argument is made in response to the limited research within geography and urban studies on neurodiversity. This paper will consider the significance of recognising and researching the multiplicity of neurodiversity in the city, especially as there are emerging initiatives for autism‐friendly cities, which require research attention and critique. This paper illustrates how appreciating the significance of neurologically diverse encounters, practices, and behaviours in cities is essential for including and accommodating neurodiversity in the city. Using theoretical framings of feminist geography, I argue for the use of intersectionality as an analytical tool to progress this research agenda, together with the use of embodied, experiential, and even multi‐sensory research methods, allowing carefully considered contributions to urban planning and policy, as well as discourse on caring and restorative cities.
A Cross-Validation Statistical Framework for Asymmetric Data Integration
Authors: Tran Lam , He Kevin , Wang Di , Jiang Hui 
Published: May 2022

Abstract
The proliferation of biobanks and large public clinical data sets enables their integration with a smaller amount of locally gathered data for the purposes of parameter estimation and model prediction. However, public data sets may be subject to context-dependent confounders and the protocols behind their generation are often opaque; naively integrating all external data sets equally can bias estimates and lead to spurious conclusions. Weighted data integration is a potential solution, but current methods still require subjective specifications of weights and can become computationally intractable. Under the assumption that local data are generated from the set of unknown true parameters, we propose a novel weighted integration method based upon using the external data to minimize the local data leave-one-out cross validation (LOOCV) error. We demonstrate how the optimization of LOOCV errors for linear and Cox proportional hazards models can be rewritten as functions of external data set integration weights. Significant reductions in estimation error and prediction error are shown using simulation studies mimicking the heterogeneity of clinical data as well as a real-world example using kidney transplant patients from the Scientific Registry of Transplant Recipients.
Haematopoietic stem cell gene therapy in inborn errors of metabolism
Authors: Chiesa Robert , Bernardo Maria Ester 
Published: May 2022

SUMMARYOver the last 30 years, allogeneic haematopoietic stem cell transplantation (allo‐HSCT) has been adopted as a therapeutic strategy for many inborn errors of metabolism (IEM), due to the ability of donor‐derived cells to provide life‐long enzyme delivery to deficient tissues and organs. However, (a) the clinical benefit of allo‐HSCT is limited to a small number of IEM, (b) patients are left with a substantial residual disease burden and (c) allo‐HSCT is still associated with significant short‐ and long‐term toxicities and transplant‐related mortality. Haematopoietic stem/progenitor cell gene therapy (HSPC‐GT) was established in the 1990s for the treatment of selected monogenic primary immunodeficiencies and over the past few years, its use has been extended to a number of IEM. HSPC‐GT is particularly attractive in neurodegenerative IEM, as gene corrected haematopoietic progenitors can deliver supra‐physiological enzyme levels to difficult‐to‐reach areas, such as the brain and the skeleton, with potential increased clinical benefit. Moreover, HSPC‐GT is associated with reduced morbidity and mortality compared to allo‐HSCT, although this needs to be balanced against the potential risk of insertional mutagenesis. The number of clinical trials in the IEM field is rapidly increasing and some HSPC‐GT products recently received market approval. This review describes the development of ex vivo HSPC‐GT in a number of IEM, with a focus on recent results from GT clinical trials and risks versus benefits considerations, when compared to established therapeutic strategies, such as allo‐HSCT.
Risk of severe late toxicity after radiotherapy following radical prostatectomy – a nationwide study
Authors: Braide Karin , Kindblom Jon , Thellenberg Karlsson Camilla , Stattin Pär , Hugosson Jonas , Månsson Marianne 
Published: May 2022

ObjectiveTo estimate the long‐term risks of severe late toxicities for radiation therapy (RT) following radical prostatectomy (RP) in an unselected nationwide cohort, as severe side‐effects are rare but may occur years later.Patients and MethodsThe study population comprised all men undergoing RP between 1997 and 2016 in the Prostate Cancer database Sweden (PCBaSe) (n = 40 962). By (1:2) matching, two cohorts were created: 2789 men exposed to postoperative RT and 5578 unexposed men with comparable age, comorbidities, and year of surgery. Cumulative incidences and rate ratios were calculated for the following outcomes: symptoms and interventions of the urinary or intestinal tract demanding inpatient care, secondary malignancies, and non‐prostate cancer mortality.ResultsThe largest differences were seen for late toxicities affecting the urinary tract. The 10‐year cumulative incidences among those exposed to postoperative RT vs the RP‐only group were: 17.8% vs 10.5% for procedures of the urinary tract (difference 7.3%, 95% confidence interval [CI] 4.4 to 10.3; relative risk [RR] 1.74, 95% CI 1.47 to 2.05); 6.0% vs 1.2% for haematuria (difference 4.8%, 95% CI 3.1 to 6.5; RR 6.50, 95% CI 4.31 to 10.10); and 2.4% vs 1.1% for bladder cancer (difference 1.4%, 95% CI 0.4 to 2.3; RR 2.71, 95% CI 1.72 to 4.33). The groups were similar regarding intestinal toxicity, other secondary malignancies, and non‐prostate cancer mortality. Adjustments for preoperative tumour risk factors did not importantly affect the rate ratios.ConclusionSevere late toxicity after postoperative RT following RP predominately affects the bladder and can appear many years after RT.
Positive feedback regulation of lncRNA TPT1‐AS1 and ITGB3 promotes cell growth and metastasis in pancreatic cancer
Authors: Cheng Chundong , Liu Danxi , Liu Zonglin , Li Mengyang , Wang Yongwei , Sun Bei , Kong Rui , Chen Hua , Wang Gang , Li Le , Hu Jisheng , Li Yilong , Chen Hongze , Zhao Zhongjie , Zhang Tao , Zhu Siqiang , Pan Shangha 
Published: May 2022

AbstractEmerging evidence has indicated that long noncoding RNAs (lncRNAs) are potential biomarkers and play crucial roles in cancer development. However, the functions and underlying mechanisms of lncRNA TPT1‐AS1 in pancreatic ductal adenocarcinoma (PDAC) remain elusive. RNAseq data of PDAC tissues and normal tissues were analyzed, and lncRNAs which were associated with PDAC prognosis were identified. The clinical relevance of TPT1‐AS1 for PDAC patients was explored, and the effects of TPT1‐AS1 in PDAC progression were investigated in vitro and in vivo. LncRNA TPT1‐AS1 was highly expressed in PDAC, and high TPT1‐AS1 levels predicted a poor prognosis. Moreover, functional experiments revealed that TPT1‐AS1 promoted pancreatic cancer cell proliferation, migration, invasion, and epithelial‐to‐mesenchymal transition (EMT) process in vitro and in vivo. Mechanistically, TPT1‐AS1 functioned as an endogenous sponge for miR‐30a‐5p, which increased integrin β3 (ITGB3) level in pancreatic cancer cells. Conversely, our data revealed that ITGB3 could activate the transcription factor signal transducer and activator of transcription 3 (STAT3), which in turn bound directly to the TPT1‐AS1 promoter and affected the expression of TPT1‐AS1, thus forming a positive feedback loop with TPT1‐AS1. Taken together, our results uncovered a reciprocal loop of TPT1‐AS1 and ITGB3 which contributed to pancreatic cancer growth and development, and indicated that TPT1‐AS1 might serve as a novel potential diagnostic biomarker and therapeutic target for PDAC patients.
Role of EMT in the DNA damage response, double‐strand break repair pathway choice and its implications in cancer treatment
Authors: Moyret‐Lalle Caroline , Prodhomme Mélanie K. , Burlet Delphine , Kashiwagi Ayaka , Petrilli Virginie , Puisieux Alain , Seimiya Hiroyuki , Tissier Agnès 
Published: May 2022

AbstractNumerous epithelial–mesenchymal transition (EMT) characteristics have now been demonstrated to participate in tumor development. Indeed, EMT is involved in invasion, acquisition of stem cell properties, and therapy‐associated resistance of cancer cells. Together, these mechanisms offer advantages in adapting to changes in the tumor microenvironment. However, recent findings have shown that EMT‐associated transcription factors (EMT‐TFs) may also be involved in DNA repair. A better understanding of the coordination between the DNA repair pathways and the role played by some EMT‐TFs in the DNA damage response (DDR) should pave the way for new treatments targeting tumor‐specific molecular vulnerabilities, which result in selective destruction of cancer cells. Here we review recent advances, providing novel insights into the role of EMT in the DDR and repair pathways, with a particular focus on the influence of EMT on cellular sensitivity to damage, as well as the implications of these relationships for improving the efficacy of cancer treatments.
Habitat suitability of neotenic net‐winged beetles (Coleoptera: Lycidae) in China using combined ecological models, with implications for biological conservation
Authors: Liu Tong , Liu Haoyu , Tong Junbo , Yang Yuxia 
Published: May 2022

AbstractAimChina has dozens of well‐recognized biodiversity hotspots, but many more potential areas have not been estimated thoroughly, which is unfavourable for biodiversity conservation. Neotenic net‐winged beetles with limited dispersal ability generally occur in restricted ranges but rarely occur in China, which makes them ideal models for biogeographical studies to define biodiversity hotspots. This study will explore the potential distribution patterns of neotenic Lycidae in China to provide basic data for the implementation of biological conservation.LocationChina.MethodsWe conducted maximum entropy (MaxEnt) and random forest (RF) modelling to simulate the habitat suitability for neotenic Lycidae occurring in China under different climate scenarios by using all available distribution information in Southeast Asia (a total of 305 occurrence records) and several environmental variables. The dynamic changes in the potentially suitable habitats and centroids of neotenic Lycidae were simulated under all climate scenarios.ResultsThe results indicated that potentially suitable habitats for neotenic Lycidae were mostly located in the montane areas and mountainous islands in southern China, including the eastern Himalayas, Gaoligong Mountains, Ailao Mountains, Hengduan Mountains, Wumeng Mountains, Miaoling Mountains, Daba Mountains, Wu Mountains, Yunkai Mountains, Wuzhi Mountains and Central Mountains. In addition, the dynamic analyses showed that their changes also occurred in montane areas, whose affinity and significance were confirmed in the biological conservation.Main conclusionsTaking the unique neotenic Lycidae as the subject, we verify that several montane areas are biodiversity hotspots that have already been well‐recognized, while it is determined that some additional mountains could be potential hotspots. Therefore, more attention and biological conservation efforts should be used in these areas. In addition, using the ensemble modelling approach to identify potential distributions is a helpful tool to develop strategies for biological conservation, even if it has several limitations.
Glycerol fermentation by skin bacteria generates lactic acid and upregulates the expression levels of genes associated with the skin barrier function
Authors: Salgaonkar Neha , Kadamkode Vinitha , Kumaran Srikala , Mallemala Prathyusha , Christy Ernest , Appavoo Shanthi , Majumdar Amitabha , Mitra Rupak , Dasgupta Anindya 
Published: May 2022

AbstractCommensal bacteria play a major role in multiple skin functions by providing the first layer of defense against pathogens and maintaining the skin barrier. Staphylococcus epidermidis is one of the most common skin commensals. In this study, we showed that S. epidermidis ferments glycerol and uses it as a nutrient, while producing short‐chain and organic fatty acids, with the most notable being lactic acid. Lactic acid is an alpha‐hydroxy acid that inhibits the growth of pathogenic bacteria, without any negative effect on the commensal bacteria itself. Using in vivo experiments, we validated our in vitro results, showing that the skin microbiome is also capable of doing this. Finally, using 2D and 3D skin culture models, we showed that the fermentation of glycerol, mainly lactic acid, as determined by analytical methods, upregulates the expression levels of several key genes that are associated with the barrier properties of the skin. While the hydration effect of glycerol on the skin is well known, our study shows the overall benefits of glycerol on the skin microbiome, while revealing an alternate mode of action of glycerol for multiple skin benefits.
Examining the impact of haemophilia treatment on health‐related quality of life
Authors: Shaikh Anum , Pedra Gabriel , Cawson Matthew , Wiseman Catherine 
Published: May 2022

AbstractIntroductionHaemophilia has substantial SD effects on health‐related quality of life (HRQoL), particularly for people with severe haemophilia. How certain aspects of haemophilia influence HRQoL is not well understood.AimTo develop predictive models of variables influencing HRQoL in people with severe haemophilia A or B.MethodsWe used data from 514 participants with haemophilia A or B who provided EQ‐5D‐3L responses in the 2015 CHESS study. Treatment was categorized as always been on‐demand (POD), previously on prophylaxis and moved to on‐demand regimen (SOD), on prophylaxis from diagnosis (PX), and prophylaxis, previously on‐demand (PXOD). Target joints were defined as ‘locations of chronic synovitis’ as reported by the treating physician. Regression models were evaluated to assess the impact of demographic and clinical covariates on HRQoL scores.ResultsSignificant covariates were generally consistent across models, with number of target joints, number of hospital admissions, and any haemophilia treatment regimen other than PX all independently negatively impacting estimated EQ‐5D score. Higher level of treatment adherence (high vs. low/medium) and use of a prophylaxis treatment regimen had positive effects on estimated EQ‐5D scores. Target joints were associated with a 0.04 decrement in EQ‐5D score, and high versus low/medium adherence was associated with a 0.06 increment. PXOD, POD, and SOD treatment regimens were associated with decrements in predicted scores of 0.07, 0.09, and 0.08, respectively, versus PX.ConclusionThis study provides a model to estimate the impact of haemophilia interventions on HRQoL, to help assess the relative impact on patient‐centric outcomes for this lifelong condition.
Effectiveness of diagnosing pulpitis: A systematic review
Authors: Donnermeyer David , Dammaschke Till , Lipski Mariusz , Schäfer Edgar 
Published: May 2022

AbstractBackgroundThe diagnosis of the status of the inflamed pulp is essential in clinical diagnosis and treatment provision. There are a limited number of well‐designed and well‐executed clinical trials on the diagnosis of the true status of the pulp.ObjectivesThree PICO questions were formulated and agreed a priori by the European Society of Endodontology to evaluate the clinical tests for sensibility testing, determination of biomarkers and pulp bleeding with regard to their suitability to correctly diagnose the condition of the pulp tissue for the development of S3‐Level guidelines.MethodsA literature search was conducted using PubMed, Clarivate Analytics' Web of Science, Scopus, Google Scholar and Cochrane Central Register of Controlled Trials from inception to 21 January 2022. Additionally, a hand search was performed, and the contents of the major subject journals were also examined. Eligibility criteria followed the proposed PICO questions. Two independent reviewers were involved in study selection, data extraction and appraising the included studies; disagreements were resolved by a third reviewer. The risk of bias was assessed by the QUADAS‐2 tool for diagnostic accuracy studies, the Newcastle–Ottawa scale for noncomparative, nonrandomized studies and the Newcastle–Ottawa Quality Assessment scale adapted for cross‐sectional studies.ResultsIn total, 28 studies out of 29 publications were considered eligible and were included in the review. Twelve studies were identified to investigate the diagnostic accuracy of the pulp vitality. Ten studies fulfilled the criteria to evaluate the diagnostic accuracy of the pulpal conditions, while 6 studies investigating the expression of biomarkers were eligible. Three studies addressing the prognostic factors and therapeutic interventions relating to pulpal status were included.DiscussionThe core problem in pulp diagnostics is that a reliable reference standard is lacking under clinical conditions. Based on limited evidence, the most promising current approach seems to define a combination of different clinical tests and symptoms, probably in future including molecular diagnosis (“diagnostic package”) will be required to ascertain the best possible strategy to clinically diagnose true pulpal conditions.ConclusionsThe effectiveness of diagnosing pulpitis is low due to limited scientific evidence regarding the accuracy and reproducibility of diagnostic tests. There is a lack of evidence to determine the true status of the pulp or to identify prognostic indicators allowing for a reliable pre‐operative estimation of the outcome of vital pulp treatment.RegistrationPROSPERO database (CRD42021265366).
Financial crises, banking regulations, and corporate financing patterns around the world
Authors: Gungoraydinoglu Ali , Öztekin Özde 
Published: May 2022

AbstractThis study examines financing behavior during financial crises in an international sample of corporate firms including 85 countries from 1987 to 2017. Measuring “financial cyclicality” as the difference between financing levels during normal times and financial crisis times, we document counter‐cyclicality in leverage and pro‐cyclicality in security issuances and debt maturity. Financial crises discourage both debt and equity issuances, with a greater decline in equity, leverage increases, and debt maturity decreases. Public debt markets partially act as spare tire during crises when bank loan supply contracts significantly. Leverage financial counter‐cyclicality is more pronounced in countries with weaker banking regulations.