bluuebunny/crossref_metadata_2025_split huggingface dataset:
Extracellular volume fraction improves risk-stratification for ventricular arrhythmias and sudden death in non-ischaemic cardiomyopathy
Authors: Di Marco Andrea , Brown Pamela F , Bradley Joshua , Nucifora Gaetano , Anguera Ignasi , Miller Christopher A , Schmitt Matthias 
Published: July 2022

AbstractAimsTo evaluate whether cardiac magnetic resonance (CMR)-based parametric mapping and strain analysis can improve the risk-stratification for ventricular arrhythmias (VA) and sudden death (SD) in non-ischaemic cardiomyopathy (NICM).Methods and resultsSecondary analysis of a prospective single-centre-registry (NCT02326324), including 703 consecutive NICM patients, 618 with extracellular volume (ECV) available. The combined primary endpoint included appropriate implantable cardioverter defibrillator therapies, sustained ventricular tachycardia, resuscitated cardiac arrest and SD. During a median follow-up of 21 months, 14 patients (2%) experienced the primary endpoint. Native T1 was not associated with the primary endpoint. Left ventricular global longitudinal strain lost its significant association after adjustment for left ventricular ejection fraction (LVEF). Among patients with ECV available, 11 (2%) reached the primary endpoint. Mean ECV was significantly associated with the primary endpoint and the best cut-off was 30%. ECV ≥ 30% was the strongest independent predictor of the primary endpoint (hazard ratio 14.1, P = 0.01) after adjustment for late gadolinium enhancement (LGE) and LVEF. ECV ≥ 30% discriminated the arrhythmic risk among LGE+ cases and among those with LVEF ≤ 35%. A simple clinical risk-stratification model, based on LGE, LVEF ≤ 35% and ECV ≥ 30%, achieved an excellent predictive ability (Harrell’s C 0.82) and reclassified the risk of 32% of the study population as compared to LVEF ≤ 35% alone.ConclusionsComprehensive CMR evaluation in NICM showed that ECV was the only parameter with an independent and strong predictive value for VA/SD, on top of LGE and LVEF. A risk-stratification model based on LGE, LVEF ≤ 35% and ECV ≥ 30% achieved an excellent predictive ability for VA/SD.Clinical Trial RegistrationUHSM CMR study (NCT02326324) https://clinicaltrials.gov/ct2/show/NCT02326324.
Non-steroidal anti-inflammatory drugs and risk of myocardial infarction adjusting for use of proton pump-inhibitors in patients with no major risk factors: a nested case-control study in the UK Clinical Practice Research Datalink
Authors: Baak Brenda N , Jick Susan S 
Published: July 2022

Abstract

Aims
Studies have found an increased risk of myocardial infarction (MI) in association with some non-steroidal anti-inflammatory drugs (NSAIDs). We evaluated this association in patients without major cardiovascular risk factors and assessed potential reverse causality bias.

Methods and results
In this nested case-control study of patients aged 40–79 in Clinical Practice Research Datalink GOLD who received at least one NSAID prescription between 2006 and 2019, we found 8639 MI cases and 34 556 matched controls. We calculated odds ratios (ORs) and 95% confidence intervals (CIs) for MI comparing NSAID users to non-exposed according to the number and timing of NSAID prescriptions and proton-pump inhibitor (PPI) use. Current diclofenac use was associated with a two-fold increased risk of MI regardless of duration of use (adjusted OR, 2.08; 95% CI, 1.82–2.38). ORs ranged from 3 to 5 among current and recent diclofenac users newly exposed to PPIs. There was no spike in risk in new current diclofenac users not exposed to PPIs, but ORs rose with increasing prescriptions. The risk of MI in ibuprofen users was concentrated in new PPI users. There was no material increased risk in naproxen users, nor in past users of most NSAIDs in the absence of PPIs.

Conclusion
The risk of MI was elevated in current diclofenac users, particularly in new concomitant PPI users. ORs increased in new users of ibuprofen and PPIs but declined with extended use and were lower in non-PPI users. This suggests that some of the findings may be explained by reverse causality bias.
Impact of multisite artery disease on clinical outcomes after percutaneous coronary intervention: an analysis from the e-Ultimaster registry
Authors: Kobo Ofer , Saada Majdi , von Birgelen Clemens , Tonino Pim A L , Íñiguez-Romo Andres , Fröbert Ole , Halabi Majdi , Oemrawsingh Rohit M , Polad Jawed , IJsselmuiden Alexander J J , Roffi Marco , Aminian Adel , Mamas Mamas A , Roguin Ariel 
Published: July 2022

Abstract

Background
Multisite artery disease is considered a ‘malignant’ type of atherosclerotic disease associated with an increased cardiovascular risk, but the impact of multisite artery disease on clinical outcomes after percutaneous coronary intervention (PCI) is unknown.

Methods
Patients enrolled in the large, prospective e-Ultimaster study were grouped into (1) those without known prior vascular disease, (2) those with known single-territory vascular disease, and (3) those with known two to three territories (i.e coronary, cerebrovascular, or peripheral) vascular disease (multisite artery disease). The primary outcome was coronary target lesion failure (TLF), defined as the composite of cardiac death, target vessel-related myocardial infarction, and clinically driven target lesion revascularization at 1-year. Inverse propensity score weighted (IPSW) analysis was performed to address differences in baseline patient and lesion characteristics.

Results
Of the 37 198 patients included in the study, 62.3% had no prior known vascular disease, 32.6% had single-territory vascular disease, and 5.1% had multisite artery disease. Patients with known vascular disease were older and were more likely to be men and to have more co-morbidities. After IPSW, the TLF rate incrementally increased with the number of diseased vascular beds (3.16%, 4.44%, and 6.42% for no, single, and multisite artery disease, respectively, P &lt; 0.01 for all comparisons). This was also true for all-cause death (2.22%, 3.28%, and 5.29%, P &lt; 0.01 for all comparisons) and cardiac mortality (1.26%, 1.91%, and 3.62%, P ≤ 0.01 for all comparisons).

Conclusions
Patients with previously known vascular disease experienced an increased risk of adverse cardiovascular events and mortality post-PCI. This risk is highest among patients with multisite artery disease.

Trial Registration: URL: https://www.clinicaltrials.gov. Unique identifier: NCT02188355.
Gap distribution mapping to visualize regions associated with type 1 endoleak in a fenestrated thoracic stent graft
Authors: Shukuzawa Kota , Fujii Tomoya , Sumi Makoto , Kozaki Junya , Umezu Mitsuo , Ohki Takao , Iwasaki Kiyotaka 
Published: July 2022

Abstract

OBJECTIVES
Our goal was to analyse the relationships between aortic surface irregularity and a type 1 endoleak (T1EL) after a thoracic endovascular repair using the Najuta fenestrated stent graft.

METHODS
The patients who were treated using the Najuta stent graft for an intact aortic arch aneurysm at the Saitama Cardiovascular and Respiratory Center between June 2013 and June 2017 were analysed retrospectively. The primary end point was the occurrence of a T1EL. The gap between a virtual aorta and the patient's aortic wall at the stent graft fixation was calculated over the whole circumference at 1 mm intervals, and gap distribution mapping was performed. The rate of freedom from a T1EL was estimated using the Kaplan–Meier method and compared between the patients with or without a continuously malapposed region of &gt;1 mm from the branches to the aneurysm.

RESULTS
Twenty-one patients were analysed. During the mean follow-up period of 21.7 months, 4 patients were confirmed to have T1ELs. Three of the T1Els were detected during the perioperative period and occurred through a fenestration. The remaining patient had a T1EL 2 years postoperatively. The gap distribution mapping confirmed the presence of a continuously malapposed region of &gt;1 mm from the cervical branch to the aneurysm postoperatively in 4 patients with T1ELs. Patients who had a continuously malapposed region of &gt;1 mm showed a statistically lower T1EL rate than those without (p &lt; 0.001). Malapposed regions defined using the gap distribution mapping were consistent with flow channels through T1EL fenestrations detected using the perioperative computed tomography data.

CONCLUSIONS
The gap distribution mapping could be useful to predict the occurrence of T1ELs in patients with the Najuta stent graft.
Impact on quinolone resistance of plasmid-mediated quinolone resistance gene and mutations in quinolone resistance-determining regions in extended spectrum beta lactamase-producing Klebsiella pneumoniae isolated from urinary tract infection patients
Authors: Onishi Reo , Shigemura Katsumi , Osawa Kayo , Yang Young-Min , Maeda Koki , Tanimoto Hiroshi , Kado Mitsuki , Fang Shiuh-Bin , Sung Shian-Ying , Miyara Takayuki , Fujisawa Masato 
Published: July 2022

ABSTRACT
Klebsiella pneumoniae is a typical pathogen in urinary tract infections (UTI), and the emergence of extended spectrum beta-lactamase (ESBL)-producing strains has been frequently reported, accompanied by higher quinolone resistance rates. There are two major mechanisms of quinolone resistance, mutations in quinolone resistance-determining regions (QRDR) and the presence of the plasmid-mediated quinolone resistance (PMQR) genes. This study aimed to investigate quinolone resistance among 105 ESBL-producing K. pneumoniae specimens isolated from UTI patients in Indonesia. These were characterized for antimicrobial resistance to nalidixic acid, ciprofloxacin, and levofloxacin, QRDR mutations in gyrA and parC and the presence of PMQR genes. We found that 84.8% of the collected isolates were resistant to at least one of the quinolones. QRDR mutation in gyrA was observed in 49.5% of these strains and parC mutations in 61.0%. PMQR genes were identified in 84.8% of strains. The QRDR mutations clearly had a greater effect on resistance than the PMQR genes. In conclusion, we found high quinolone resistance rates in Indonesian ESBL-producing K. pneumoniae, in which QRDR mutation played a major role.
A Genome for Edith’s Checkerspot Butterfly: An Insect with Complex Host-Adaptive Suites and Rapid Evolutionary Responses to Environmental Changes
Authors: Tunstrom Kalle , Wheat Christopher W , Parmesan Camille , Singer Michael C , Mikheyev Alexander S 
Published: July 2022

Abstract
Insects have been key players in the assessments of biodiversity impacts of anthropogenically driven environmental change, including the evolutionary and ecological impacts of climate change. Populations of Edith’s Checkerspot Butterfly (Euphydryas editha) adapt rapidly to diverse environmental conditions, with numerous high-impact studies documenting these dynamics over several decades. However, studies of the underlying genetic bases of these responses have been hampered by missing genomic resources, limiting the ability to connect genomic responses to environmental change. Using a combination of Oxford Nanopore long reads, haplotype merging, HiC scaffolding followed by Illumina polishing, we generated a highly contiguous and complete assembly (contigs n = 142, N50 = 21.2 Mb, total length = 607.8 Mb; BUSCOs n = 5,286, single copy complete = 97.8%, duplicated = 0.9%, fragmented = 0.3%, missing = 1.0%). A total of 98% of the assembled genome was placed into 31 chromosomes, which displayed large-scale synteny with other well-characterized lepidopteran genomes. The E. editha genome, annotation, and functional descriptions now fill a missing gap for one of the leading field-based ecological model systems in North America.
Integrated collaborative care intervention for depression and obesity in primary care: translation from research to practice
Authors: Ronneberg Corina R , Lv Nan , Ajilore Olusola A , Gerber Ben S , Venditti Elizabeth M , Snowden Mark B , Steinman Lesley E , Wittels Nancy E , Barve Amruta , Dosala Sushanth , Rosas Lisa G , Kringle Emily A , Ma Jun 
Published: July 2022

Abstract
The objective of this study was to present lessons learned about engagement, delivery modality and pandemic impact while delivering a collaborative care intervention with a socioeconomically, racially and ethnically diverse sample. Participants completed a post-intervention survey (n = 41) on experiences and preferred intervention delivery modality, coronavirus 2019 (COVID-19) Impact Survey (n = 50) and provided open-ended feedback about the intervention (n = 27). Intervention process data included attendance, modality, and withdrawals. Data were analyzed using descriptive statistics and inductive content analyses. Of 71 intervention participants, 6 (8%) withdrew before session 1. Completers adhered to intervention timeline better than withdrawals. Participants liked the in-person interaction, efficient coach support, accountability of in-person and Zoom vs. phone sessions and the flexibility and convenience of phone and Zoom vs. in-person sessions. A majority of participants reported experiencing pandemic impacts such as heightened emotional distress, decreased activity engagement, poorer eating behaviors and being unable to meet basic needs. Participants deviating from intervention timelines may be re-engaged by targeted outreach attempts. Videoconference has the potential for providing as-needed coaching. Future interventions may be optimized to account for and address areas impacted by the pandemic. Findings revealed specific strategies that can be implemented in future interventions to improve emotional and physical health among diverse populations.
Quality level and outsourcing strategies in a three-tier low-carbon supply chain
Authors: Wu Xinjian , Yu Chao , Zhang Suyong 
Published: July 2022

Abstract
We analyze the quality risk and outsourcing strategies in a three-tier low-carbon supply chain comprising an original equipment manufacturer (OEM), a contract manufacturer (CM) and a supplier under two competitive scenarios. The following two outsourcing strategies that are currently implemented by OEM are considered: consignment and turnkey. Under the consignment strategy, the OEM procures the components from the supplier and then outsources the product manufacturing to the CM. Under the turnkey strategy, the OEM outsources the component procurement and product manufacturing to the CM and CM procures the components from the supplier. We compare the quality level and two outsourcing strategies under non-competitive scenario in which the CM does not have its own brand products and competitive scenario in which the CM sells its own brand production. It is shown that, in the non-competitive scenario, OEM prefers the turnkey strategy than the consignment strategy in the low-carbon supply chain. In the competitive scenario, the OEM’s outsourcing strategy depends on the CM’s quality investment cost coefficient.
Targeted SARS-CoV-2 treatment is associated with decreased mortality in immunocompromised patients with COVID-19
Authors: Lafont Emmanuel , Pere Hélène , Lebeaux David , Cheminet Geoffrey , Thervet Eric , Guillemain Romain , Flahault Adrien 
Published: July 2022

Abstract

Background
Little is known about targeted (antiviral or monoclonal antibody) anti-SARS-CoV-2 treatment in immunocompromised patients with COVID-19.

Objectives
To assess the real-life efficacy and tolerance of targeted treatment of COVID-19 in immunocompromised patients.

Patients and methods
Single-centre retrospective case series of immunocompromised patients with COVID-19 between December 2021 and March 2022. We recorded all cases of COVID-19 among immunocompromised patients treatment between 20 December 2021 and 15 March 2022. Choice of treatment was left to the physician’s decision, according to internal treatment protocol, treatment availability and circulating variants. Main outcome was death from COVID-19 after no treatment or targeted treatment.

Results
Sixty-seven immunocompromised patients [38 male; median (IQR) age, 53 (43–63) years], with a median (IQR) follow-up of 60 (47–80) days. Ten patients did not receive any targeted treatment. Targeted treatment consisted of IV curative remdesivir (n = 22), sotrovimab (n = 16), tixagevimab/cilgavimab (n = 13) and casirivimab/imdevimab (n = 1). Ten patients (15%) presented severe COVID-19 and 2 (3%) died from Omicron COVID-19. Comparing patients who received targeted anti-SARS-CoV-2 treatment and no prophylaxis, (n = 42; 81%) with those who did not (n = 10; 19%), death rate was significantly lower in treated patients [n = 0 (0%) versus n = 2 (20%); P = 0.034]. No severe adverse events were reported among treated patients. Among 15 patients who received tixagevimab/cilgavimab as pre-exposure prophylaxis, 6 received an additional curative treatment and none died from COVID-19.

Conclusions
Our results suggest that targeted COVID-19 treatment, including direct antivirals or monoclonal antibodies, is safe and efficient and could be proposed in high-risk immunocompromised patients.
Juvenile drift of an invasive crayfishFaxonius virilis(Hagen, 1870) (Decapoda: Astacidea: Cambaridae) in the middle Pecos River, New Mexico, USA
Authors: Ricklefs Sara A , Filbrun Jesse E 
Published: July 2022

AbstractEcologists have long recognized that dispersal capabilities influence range expansion by nonnative species. Some of the most disruptive crayfish invaders are highly mobile as adults within and across watershed networks. In this study, we contribute a new facet to our understanding of crayfish early life history and invasions by documenting strong evidence of synchronized, behavioral downstream drift by early juveniles. During 2019, we observed a relatively dense springtime pulse of juvenile crayfish in drift nets set at two sites in the middle Pecos River near Fort Sumner, New Mexico. To determine whether this was an anomalous episode or an annual event, we sampled in 2020 and 2021 to: 1) determine the timing and extent of drifting behavior relative to environmental variation, and 2) identify the drifters to species level using DNA barcoding. Across three years, we collected juvenile crayfish (2.4–13.1 mm carapace length) after sunset during April through June in relatively clear water conditions (5–64 NTU) that coincided with minimum flows (41–152 cfs) and seasonally typical temperatures for this region (15–26 °C). To identify specimens to species level, we sequenced the barcoding region of the cytochrome c oxidase I (COI) DNA barcode for 35 juveniles and 6 adult male vouchers that represented all years. Based on morphological identifications of adult males and COI sequence comparisons to published reference specimens, nearly all drifting juveniles were identified as Virile Crayfish Faxonius virilis (Hagen, 1870). Drifters matched the sizes of second-molt juveniles newly released in the laboratory from two brooding females that we captured in the field. Faxonius virilis has been collected throughout the Rio Grande watershed, but not yet been reported in the Pecos River. As drifting early life stages are common across crustaceans, we suspect juvenile crayfish drift is probably not unique to F. virilis nor to our study system. We encourage others to perform targeted surveys of juvenile drift across a broad range of study systems, and to identify causal factors and ecological consequences of juvenile drift using controlled experiments.
“Music Therapy Was Never on the Table”: Perspectives of Parents of Young Autistic Children
Authors: Hernandez-Ruiz Eugenia , Lehrer Gabriel 
Published: July 2022

Abstract
Parent coaching of music interventions is emerging as a viable model for families with young autistic children, yet recruitment difficulties have been apparent in previous studies. Understanding parent perspectives of early intervention services is critical to ensure that interventions are acceptable, feasible, and effective for all family members. In order to understand possible parental resistance to this type of parent education, we explored perspectives regarding music therapy, research, and parent coaching in parents of young autistic children. Fourteen parents attended virtual focus groups to discuss their experiences. We used a descriptive phenomenological approach to uncover the essence of their experience. Our findings indicate that, contrary to our preconceptions, participants did not show negative dispositions towards music therapy, research, or parent coaching. Instead, most participants had very little or no knowledge of music therapy services. They had limited experience with research in general, and only two participants had experienced music therapy directly. Several participants had varying amounts of experience with parent participation or parent coaching outside of music therapy and shared positive experiences with it. Parents seemed willing and eager to learn music strategies to support their children and saw value in the use of music for their child’s development. First-contact providers (i.e., early interventionists and diagnosticians) and social media seem influential in parents’ decision-making as they navigate early intervention services soon after diagnosis. Music therapy organizations are encouraged to design targeted efforts to make information on music therapy available through these sources.
Working toward Socially Responsive Recruitment Practices of Psychology Interns in an Academic Medical Center
Authors: Glover Jenna , Lynn Courtney , Holzman Jacob B W , Germone Monique , Talmi Ayelet 
Published: July 2022

Abstract

Objective
This study describes a quality improvement (QI) process to reduce bias and increase inclusion and equity in the recruitment of health service psychology interns in an American Psychological Association-accredited psychology internship program at a national children’s hospital.

Methods
This QI project utilized two Plan-Do-Study-Act (PDSA) cycles targeting the application review and the interview processes primarily using supervisor engagement and feedback to inform these processes. The goal of the PDSA cycles was to increase diversity in psychology doctoral interns offered interviews and ultimately recruited to the internship program.

Results
The application rating form was revised to place a greater emphasis on factors related to diversity, such as increasing the number of points applicants could earn for being bilingual. Regarding the interview process, structured interview questions were created, and a new, unified rubric was used to score interviewees. The changes in demographics of applicants selected for interviews and feedback from applicants who interviewed are reported.

Conclusions
The QI process resulted in tangible changes to improve equitable and inclusive internship recruitment. Lessons learned throughout this process included the need for continual auditing of practices through an equity lens, engaging supervisors at all stages of the process, and implementing incremental actions.