bluuebunny/crossref_metadata_2025_split huggingface dataset:
Getting Permission to Break the Rules: Clergy Respond to LGBTQ Exclusion in the United Methodist Church
Authors: Gilliland Claire Chipman , Krull Laura M 
Published: April 2022

AbstractOrganizational scholars expect organizations to conform to the norms and expectations of their institutional environments. In some cases, though, organizations may reject rules if they perceive a greater advantage to defiance than to conformity. This project analyzes a sample of sermons given by United Methodist Church (UMC) clergy surrounding the 2019 UMC General Conference. We focus on a subset of sermons in which clergy explicitly mention they will not follow denominational rules, meaning they will marry and ordain LGBTQ people, to investigate how clergy legitimize their rule breaking. We find that clergy draw on several sources of religious authority to justify their decisions, including meso-level structures in the UMC tradition, the autonomy of local congregations, and religious texts and leaders. This project provides empirical evidence of how organizations resist institutional pressure and construct their decision as legitimate, with implications for other organizations and for LGBTQ inclusion.
Not Your Grandma’s Fascism: Fame, Femininity, and Race in Far-Right Postcolonial India and Brazil
Authors: Leidig Eviane , Bayarri Gabriel 
Published: April 2022

AbstractMuch scholarship on the far right focuses on Europe and North America, whereas case studies outside of these regions are often neglected or not recognized as constituting the same phenomenon. In this article, we compare two democracies in the Global South—India and Brazil—to showcase far-right movements within these countries. We situate the “postcolonial neoliberal nationalism” that has shaped the basis of far-right claims in India and Brazil. To illuminate this, we explore female social media influencers within these far-right milieus, and their role in the reproduction of gender, class, and racial hierarchies. Combined with this are insights from media studies on influencer culture as a means of analyzing the performativity of far-right women to advance exclusionary agendas. Overall, we highlight the inherent contradictions and complexity of how far-right female influencers in the Global South are promoting local expressions of gendered indigeneity while also contributing to global far-right narratives.
Novel Posterior Anchoring Method Associated With Medial Meniscus Posterior Root Repair
Authors: Okazaki Yuki , Furumatsu Takayuki , Hiranaka Takaaki , Kintaka Keisuke , Zhang Ximing , Kodama Yuya , Kamatsuki Yusuke , Yamawaki Tadashi , Ozaki Toshifumi 
Published: April 2022

Introduction:
Transtibial pullout repair is the gold standard surgical treatment for medial meniscus (MM) posterior root tear. However, posteromedial extrusion of the MM during knee flexion may remain a problem postoperatively.

Materials and Methods:
We used a novel posterior anchoring technique to help reduce posteromedial extrusion, applying two cinch sutures (TCSs) to the MM posterior horn and creating a bone tunnel at the center of the posterior root attachment to pullout the suture. Another bone tunnel was created at the posterior corner of the medial tibial plateau in the externally rotated knee flexion. The first anchor of an all-inside meniscal repair device was inserted through the inferior surface of the MM posterior horn with tensioning TCS and the second anchor into the bone tunnel. Tibial fixation of pullout sutures was performed using a bioabsorbable screw in 30 degrees knee flexion.

Conclusions:
Our posterior anchoring method, combined with conventional pullout repair with TCS, helped reduce posteromedial extrusion in patients with a MM posterior root tear.
SWEPT-SOURCE OPTICAL COHERENCE TOMOGRAPHY DETECTION OF BRUCH MEMBRANE AND CHORIOCAPILLARIS ABNORMALITIES IN SORSBY MACULAR DYSTROPHY
Authors: Iyer Prashanth G. , Zhou Hao , Zhang Qinqin , Chu Zhongdi , Shen Mengxi , Shi Yingying , Liu Jeremy , Trivizki Omer , Lam Byron L. , Wang Ruikang K. , Gregori Giovanni , Rosenfeld Philip J. 
Published: April 2022

Purpose:
Swept-source optical coherence tomography angiography (SS-OCTA) was used to analyze Bruch membrane (BM) and choriocapillaris (CC) abnormalities in undiagnosed family members with Sorsby macular dystrophy (SMD).

Methods:
In a family with SMD (TIMP3 Tyr191Cys), SS-OCTA imaging was performed using the 6 × 6 mm scan patter and previously validated algorithms to detect abnormalities in BM and the CC, as well as the presence of reticular pseudodrusen and macular neovascularization. Genetic analyses were performed for TIMP3 mutations.

Results:
Of eight family members, two were previously diagnosed with SMD and six were asymptomatic. SS-OCTA imaging of the 33-year-old proband revealed type 1 macular neovascularization in the left eye and bilateral reticular pseudodrusen, thickening of BM, CC thinning, and increases in CC flow deficits. A TIMP3 mutation was confirmed. His niece, despite having no clinical evidence of SMD, showed BM thickening and CC thinning on SS-OCTA. A TIMP3 mutation was confirmed. The proband's younger nephew and niece also carried the TIMP3 mutation without clinical evidence of SMD. Two additional members had normal examinations, unremarkable SS-OCTA findings, and no TIMP3 mutation.

Conclusion:
Swept-source optical coherence tomography angiography imaging can detect BM and CC abnormalities in vivo in subjects unaware of their TIMP3 status in a family with SMD.
Normalized Kinematic Walking Symmetry Data for Individuals Who Use Lower-Limb Prostheses: Considerations for Clinical Practice and Future Research
Authors: Finco MG , Moudy Sarah C. , Patterson Rita M. 
Published: April 2022

ABSTRACT

Introduction
Individuals who use unilateral transtibial or transfemoral prostheses have negative secondary health effects associated with decreased kinematic (e.g., spatiotemporal and joint angle) walking symmetry between prosthetic and intact limbs. Research studies have quantified kinematic walking symmetry, but studies can be difficult to compare owing to the inclusion of small sample sizes and differences in participant demographics, biomechanical parameters, and mathematical analysis of symmetry. This review aims to normalize kinematic walking symmetry research data across studies by level of limb loss and prosthetic factors to inform considerations in clinical practice and future research.

Methods
A search was performed on March 18, 2020, in PubMed, Scopus, and Google Scholar to encompass kinematic walking symmetry literature from the year 2000. First, the most common participant demographics, kinematic parameters, and mathematical analysis of symmetry were identified across studies. Then, the most common mathematical analysis of symmetry was used to recalculate symmetry data across studies for the five most common kinematic parameters.

Results
Forty-four studies were included in this review. The most common participant demographics were younger adults with traumatic etiology who used componentry intended for higher activity levels. The most common kinematic parameters were step length, stance time, and sagittal plane ankle, knee, and hip range of motion. The most common mathematical analysis was a particular symmetry index equation.

Conclusions
Normalization of data showed that symmetry tended to decrease as level of limb loss became more proximal and to increase with prosthetic componentry intended for higher activity levels. However, most studies included 10 or fewer individuals who were active younger adults with traumatic etiologies.

Clinical Relevance
Data summarized in this review could be used as reference values for rehabilitation and payer justification. Specifically, these data can help guide expectations for magnitudes of walking symmetry throughout rehabilitation or to justify advanced prosthetic componentry for active younger adults under 65 years of age with traumatic etiologies to payers.
Prognostic role of SPRY4-IT1 in female breast carcinoma and malignant tumors of the reproductive system
Authors: Qin Xiaoru , Yin Qifan , Gao Jin , Shi Xiaoming , Tang Jiachen , Hao Lingling , Li Pengfei , Zhu Jia , Wang Yuexin 
Published: April 2022

Abstract

Background:
The prognostic value of SPRY4-Intronic transcript 1 (SPRY4-IT1) in women suffering from breast carcinoma and malignant tumors of the reproductive system remains to be ascertained. Therefore, this paper attempted to assess the relationship between SPRY4-IT1 with the clinicopathological indicators and survival analysis in women suffering from breast carcinoma and malignant tumors of their reproductive organs through meta-analysis.

Method:
Related literature retrieved from Cochrane Library, Ovid, Embase, PubMed, the CNKI, and the Web of Science databases were reviewed. The latest article search was updated to September 1, 2021. The outcome indicators included as effective measures in the study were hazard ratio (HR), odds ratio (OR), and 95% confidence interval (CI). The Stata 12.0 software was used to analyze the data.

Results:
The elevated SPRY4-IT1 levels were indicative of poor overall survival (OS) [HR = 2.44, 95% CI = 1.35–4.43, P < .05], and were not related to Disease-Free Survival (DFS) [HR = 1.61, 95% CI = 0.50–5.18, P = .43] in female patients suffering from malignant tumors. In terms of lymph node metastasis (LNM) for the association between long noncoding RNA SPRY4-IT1(LncRNA SPRY4-IT1) and OS, elevated LncRNA SPRY4-IT1 implied poor OS with LNM [HR = 2.79, 95% CI: 1.81–4.28, P < .001]. Based on the aspect of the LNM for the association between LncRNA SPRY4-IT1 and DFS, SPRY4-IT1 was not correlated with DFS [HR = 0.97, 95% CI: 0.73–1.28, P = .81]. SPRY4-IT1 in the TNM stage was not related to OS [HR = 1.43, 95% CI: 0.55–3.70, P = .46]. In the TNM stage, SPRY4-IT1 was not related to DFS [HR = 1.68, 95% CI: 0.92–3.06, P = .09]. SPRY4-IT1 was found to be associated with lymph node metastasis (OR = 4.15, 95% CI: 2.75–6.25, P = .000) and TNM stage (OR = 2.89, 95% CI: 1.51–7.27 P = .02). No significant correlation was noted between SPRY4-IT1 and the age of the patients (OR = 0.89, 95% CI: 0.61–1.29 P = .54).

Conclusions:
Thus, this study provides evidence-based medical evidence for the target treatment of female breast carcinoma and malignant tumors of the reproductive system. The elevated level of SPRY4-IT1 was associated with poor prognosis of female breast cancer patients and of those having malignant tumors in their reproductive organs. In addition, the SPRY4-IT1 expression was also associated with the disease progression and metastasis.
Radiotherapy-induced isolated left main coronary artery disease presenting with cardiogenic shock
Authors: Li Bo , Liu Yuan , Lou Zhiyang , Zhang Weihua , Zhang Mingyou , Liu Quan 
Published: April 2022

Abstract

Rationale:
Mediastinal radiotherapy is a common practice for treating breast cancer and Hodgkin's lymphoma. Radiotherapy causes cardiovascular damage and has attracted increasing attention, particularly among Hodgkin's lymphoma patients, as they receive a higher dose of radiation.

Patient concerns:
A 36-year-old woman with a past medical history of Hodgkin's lymphoma presented with persistent chest pain for 3 hours. She experienced exertional chest pain 1 month before when she was climbing stairs, which disappeared after a few minutes with rest, but recurred with a similar level of exertion. Three hours before admission to the emergency room, the chest pain persisted and was accompanied by diaphoresis and dyspnea.

Diagnosis:
Cardiogenic shock caused by radiotherapy-induced left main coronary artery disease.

Interventions:
Urgent angiography revealed left main coronary artery stenosis. Intravascular ultrasonography showed diffuse fibrous proliferation in the left main coronary artery. Hemodynamic instability was resolved after drug-eluting stent implantation.

Outcomes:
The patient was discharged uneventfully 5 days after the procedure, with a prescription for dual antiplatelet and statin therapy. She was asymptomatic with good exercise tolerance at the 3-month follow-up.

Conclusion:
Radiotherapy-induced isolated left main coronary artery disease is a rare complication of cancer radiotherapy and can occur years or decades after treatment. Fibrous proliferation is a characteristic pathologic change in the exposed coronary arteries.
The effectiveness of Salvianolate injection for in-stent restenosis after percutaneous coronary intervention
Authors: Zhang Miao , Yuan Yue , Gao Ying , Lu Ruozhu , Deng Yue 
Published: April 2022

Abstract

Background:
In-stent restenosis (ISR) caused by vascular remodeling after percutaneous coronary intervention limits the long-term efficacy of this method. Salvianolate injection is now widely used in the clinical treatment of ISR. However, there is no systematic review or meta-analysis to evaluate the effects of Salvianolate injection on ISR.

Methods:
We will search articles in 8 electronic databases, including the Cochrane Central Register of Controlled Trials, PubMed, Embase, the Web of Science, China National Knowledge Infrastructure, the Chinese Biomedical Literature Database, Wanfang Database, and the Chinese Scientific Journal Database for randomized controlled trials of ISR treated by Salvianolate injection from their inception to February 27, 2022. The primary outcome measure will be the restenosis rate. The data meeting the inclusion criteria were analyzed by RevMan V.5.4 software. Two authors evaluated the study using the Cochrane collaborative risk bias tool. We will use a scoring method to assess the overall evidence supporting the main results.

Results:
This study will analyze the clinical effectiveness of Salvianolate injection in the treatment of ISR.

Conclusion:
The findings of this systematic review will provide evidence to evaluate the effectiveness of Salvianolate injection for the treatment of ISR.

INPLASY registration number:
INPLASY202220117.
Initiation of the pharmacist-delivered antidiabetic medication therapy management services in a tertiary care hospital in Nepal
Authors: Sapkota Binaya , Bokati Priyanka , Dangal Salina , Aryal Pooja , Shrestha Sunil 
Published: April 2022

Abstract
The medication therapy management (MTM) pharmacists follow the philosophy of pharmaceutical care to address individualistic medication therapy requirements in their practice settings.
The present study aimed to introduce the pharmacist-delivered MTM services among type 2 diabetes mellitus patients at a tertiary care hospital in Nepal.
Cross-sectional study was conducted at Patan Hospital, Lalitpur, Nepal, among 200 patients with type 2 diabetes mellitus from July to December 2019. The intervention included maintenance of medication profile for individual patients, and then MTM service was proposed based on 5 core elements of MTM services proposed by the American Pharmacists Association. Both antidiabetic and non-antidiabetic medicines were coded as per the anatomic, therapeutic, and chemical classification and defined daily dose assignment 2020 for documentation. The Charlson Comorbidity Index was used to index comorbidities. The drug interaction profile was checked with the Medscape Drug Interaction Checker.
Both fasting and postprandial blood sugar levels were significantly associated with age (P-values <.000 for both), baseline symptom (P-values .012 and .003 respectively), and diet plan proposed (P-values .049 and .011 respectively). Maximum cases of drug interactions requiring close monitoring were between metformin and insulin regular (i.e., 11, 5.5%).
This was a novel initiative of the MTM services in a resource constraint country like Nepal and can show a clue for the pharmacists targeting such services in other similar settings.
A Pediatric-Specific View on Improved Nurse-Sensitive Indicators Related to Increased BSN or Higher Rates Over Time
Authors: Hupp Diane S. , Mastrangelo Beth , Nelson Kimberly A. , Weyant Donna M. , Schreiber James B. 
Published: April 2022

Background:
Nurses obtaining higher levels of education has been recommended nationally for more than a decade to support improved patient outcomes.

Local Problem:
Organizational strategies were implemented to achieve a highly educated workforce at the project site over 14 years. However, there was no evaluation of relationship with increasing education levels and pediatric patient outcomes.

Methods:
A quality improvement project explored the relationship of Bachelor of Science in Nursing (BSN) or higher prepared nurses with 9 different nurse-sensitive indicators (NSIs). Educational preparation and NSI data were retrieved retrospectively from hospital databases from up to 14 years.

Results:
Moderate to moderately strong correlations were noted between the proportion of BSN or higher prepared nurses and 2 NSIs (central line–associated bloodstream infections, r = −0.55 and surgical site infections, r = −0.71). Four of the 9 indicators were approaching moderate correlation.

Conclusions:
Increasing the proportion of highly educated nurses at the project site correlated with improvements in select NSI outcomes.
Effect of the Coronary Arterial Diameter Derived From Coronary Computed Tomography Angiography on Fractional Flow Reserve
Authors: Liu Jincheng , Huang Suqin , Wang Xue , Li Bao , Ma Junling , Sun Hao , Xi Xiaolu , Sun Yutong , Zhang Liyuan , Liu Jian , Liu Zhuo , Liu Youjun 
Published: April 2022

Background
Fractional flow reserve (FFR) is considered to be the criterion standard for the clinical diagnosis of functional myocardial ischemia. In this study, we explored the effect of the coronary arterial diameter derived from coronary computed tomography angiography on FFR.

Method
We retrospectively reviewed the clinical information of 131 patients with moderate coronary artery stenosis. To compare the mean diameter of stenotic vessels, patients were divided into ischemic and nonischemic groups. According to the clinical statistics of the diameter of the ischemic group and the nonischemic group, we established 8 ideal models of coronary artery diameter of 4 mm (40%, 50%, 60%, and 70% stenosis) and diameter of 3 mm (40%, 50%, 60%, and 70% stenosis). Two sets of numerical simulation experiments were carried out: experiment 1 evaluated the variation rate of CT-based computation of non-invasive fractional flow reserve (FFRCT) with vessel diameters of 4 mm and 3 mm under different stenosis rates, and experiment 2 explored the variation of FFRCT with vessel diameters of 4 mm and 3 mm under different cardiac outputs. We simulated changes in the flow of narrow blood vessels by changes in cardiac output.

Results
According to clinical statistics, the mean ± SD diameter of stenotic vessels in the ischemic and nonischemic groups was 3.67 ± 0.77 mm and 3.31 ± 0.64 mm (P < 0.05 for difference), respectively. In experiment 1, the FFRCT of coronary with a diameter of 4 mm was 0.86, 0.80, 0.66, and 0.35, and that with a diameter of 3 mm was 0.90, 0.84, 0.71, and 0.50, respectively. In experiment 2, the FFRCT of the coronary vessel diameter of 4 mm was 0.84, 0.80, 0.76, and 0.72, respectively. The FFRCT coronary vessels with a diameter of 3 mm were 0.87, 0.84, 0.80, and 0.76, respectively.

Conclusions
As the stenosis increases, compared with narrow blood vessel of small diameter, the narrow blood vessel with larger diameter is accompanied by faster flow rate changes and is more prone to ischemia.
High Body Mass Index and Change in Cervical Carotid Artery Position on Serial Scans: A Retrospective Study of an Unexplained Phenomenon
Authors: Nayate Ameya P. , Durieux Jared 
Published: April 2022

Objective
The purpose of this study was to investigate the relationship between increased body mass index (BMI) and abdominal circumference and prevalence of the change of position of common and internal carotid arteries on serial imaging, termed wandering carotid artery.

Methods
We retrospectively reviewed computed tomography/magnetic resonance imaging neck scans and determined whether the common and internal carotid arteries moved in position on serial scans. We correlated patients' demographic and medical information along with abdominal circumference, BMI, location of the aortic arch, and area of soft tissue surrounding the carotid arteries with the prevalence of a wandering carotid artery.

Results
Computed tomography/magnetic resonance imaging neck performed on 56 randomly selected patients between 2017 and 2020 were reviewed. A total of 42.9% of the patients had a wandering common or internal carotid artery. The abdominal circumference and BMI were significantly higher in the patients with wandering carotid arteries compared with the patients without (abdominal circumference = 102.9 ± 14.13 vs 91.61 ± 13.9 cm [P = 0.01] and BMI = 34.27 ± 8.58 [obese] vs 26.21 ± 4.89 [overweight, P = 0.0001]). After adjusting for age, sex, hypertension, diabetes, atherosclerosis grade, and aortic arch location, the odds of wandering carotid artery was 1.23 (95% confidence interval, 1.1–1.44) times higher for every one-unit increase in BMI.

Conclusions
There is a higher prevalence of wandering common and internal carotid arteries in obese patients with large abdominal circumference irrespective of age, sex, diabetes, hypertension, or carotid atherosclerosis.
Three-Dimensional Isotropic Versus Conventional Multisequence 2-Dimensional Magnetic Resonance Imaging of Sacroiliac Joints in Suspected Axial Spondyloarthritis
Authors: Gupta Anurag , Ratakonda Raghu , Boraiah Girish , Xi Yin , Chhabra Avneesh 
Published: April 2022

Objectives
The aims of the study were to systematically evaluate the sacroiliac joints of a consecutive series of patients with clinically suspected axial spondyloarthritis and to compare the diagnostic efficacy of 3-dimensional (3D) imaging versus conventional multisequence 2D techniques for sacroiliitis.

Methods
In this cross-sectional multireader validation study, imaging studies of 104 consecutive patients with clinically suspected axial spondyloarthritis obtained with a rheumatology lumbosacral magnetic resonance imaging protocol were evaluated. Three-dimensional coronal oblique reconstructions parallel to the long axis of the sacrum were created. Two blinded readers evaluated 2D and 3D images separately for each study, and findings were compared with the reference standard for the final diagnosis and disease activity. Cohen κ and diagnostic performance measures on 2D and 3D imaging were evaluated and compared.

Results
With 2D versus 3D imaging, respectively, the sensitivity for detecting inflammatory cases was 57% versus 62% (P = 0.1007), the sensitivity for detecting mechanical cases was 89% versus 76% (P = 0.0312), the sensitivity for detecting active sacroiliitis was 49% versus 64% (P = 0.0014), and the specificity for detecting active sacroiliitis was 87% versus 76% (P = 0.0016). Interreader agreement of 2D imaging showed an overall range of κ = 0.27–0.85, and it was best for evaluation of bony ankylosis (κ = 0.85). Interreader agreement of 3D imaging was in an overall range of κ = 0.15–0.64.

Conclusions
Single 3D isotropic magnetic resonance imaging provided adequate assessment of sacroiliac joints in this study and demonstrated significantly higher sensitivity and lower specificity for detecting active sacroiliitis. The initial results indicate that 3D imaging could be used for future works for screening sacroiliitis and abdominopelvic enthesopathy.