bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exploration of the Role of Serine Proteinase Inhibitor A3 in Alcohol Dependence Using Gene Expression Omnibus Database
Authors: Zhang Bo , Wang Gang , Huang Cheng Bing , Zhu Jian Nan , Xue Yong , Hu Jian 
Published: January 2022

Background: Alcohol dependence is an overall health-related challenge; however, the specific mechanisms underlying alcohol dependence remain unclear. Serine proteinase inhibitor A3 (SERPINA3) plays crucial roles in multiple human diseases; however, its role in alcohol dependence clinical practice has not been confirmed.Methods: We screened Gene Expression Omnibus (GEO) expression profiles, and identified differentially expressed genes (DEGs). Protein-protein interaction (PPI) networks were generated using STRING and Cytoscape, and the key clustering module was identified using the MCODE plugin. SERPINA3-based target microRNA prediction was performed using online databases. Functional enrichment analysis was performed. Fifty-eight patients with alcohol dependence and 20 healthy controls were recruited. Clinical variables were collected and follow-up was conducted for 8 months for relapse.Results:SERPINA3 was identified as a DEG. ELANE and miR-137 were identified after PPI analysis. The enriched functions and pathways included acute inflammatory response, response to stress, immune response, and terpenoid backbone biosynthesis. SERPINA3 concentrations were significantly elevated in the alcohol dependence group than in healthy controls (P &lt; 0.001). According to the median value of SERPINA3 expression level in alcohol dependence group, patients were divided into high SERPINA3 (≥2677.33 pg/ml, n = 29) and low SERPINA3 groups (&lt;2677.33 pg/ml, n = 29). Binary logistic analysis indicated that IL-6 was statistically significant (P = 0.015) Kaplan-Meier survival analysis did not indicate any difference in event-free survival between patients with low and high SERPINA3 levels (P = 0.489) after 8 months of follow-up. Receiver characteristic curve analysis revealed that SERPINA3 had an area under the curve of 0.921 (P &lt; 0.0001), with a sensitivity and specificity of 93.1 and 80.0%, respectively. Cox regression analysis revealed that aspartate transaminase level was a negative predictor of relapse (β = 0.003; hazard ratio = 1.003; P = 0.03).Conclusions:SERPINA3 level was remarkably elevated in patients with alcohol dependence than healthy controls, indicating that SERPINA3 is correlated with alcohol dependence. However, SERPINA3 may not be a potential predictive marker of relapse with patients in alcohol dependence.
The Atacama Desert in Northern Chile as an Analog Model of Mars
Authors: Azua-Bustos Armando , González-Silva Carlos , Fairén Alberto G. 
Published: January 2022

The Atacama Desert is by far the driest and oldest desert on Earth, showing a unique combination of environmental extremes (extreme dryness, the highest UV radiation levels on Earth, and highly saline and oxidizing soils), explaining why the Atacama has been largely investigated as a Mars analog model for almost 20 years. Based on the source and the amount of water available for life and its analogy with Mars, two ecosystems are of interest in the Atacama: its Coastal Range and the much drier hyperarid core, which we here review in detail. Members of the three domains of life have been found across these ecosystems living at the limit of habitability, suggesting the potential dry limits for each domain and also unveiling the highly patchy distribution of microbial life in its most extreme regions. The thorough study of the Atacama has allowed us to understand how life has adapted to its extreme conditions, the specific habitats that life occupies in each case (thus suggesting the most likely places in which to search for evidence for life on Mars), and the number of biosignatures detected across this desert. Also, the characterization of west-to-east transects across this desert has shown to be of significant value to understand the potential adaptations that Martian microorganisms may have followed in an ever-drying planet. All of this explains why the Atacama is actively used as the testing ground of the technologies (detection instruments, rovers, etc.) that were sent and will be sent to Mars. We also highlight the need to better inform the exact locations of the sites studied to understand general trends, the need to identify the true native microbial species of the Atacama, and the impact of climate change on the most arid and most Martian desert of Earth.
Metal Accumulation Properties of Eight Traditionally Utilized Nutritional Plants and Their Potential as Suitable Crops for Cultivation on Acidic Soils of the Northern Province Uíge, Angola
Authors: Baumgärtel Christin , Lautenschläger Thea , Panzo Mazekana H. G. , Afonso Francisco , Neinhuis Christoph , Feger Karl-Heinz 
Published: January 2022

High metal contents of acidic soils from sub-Saharan Africa often prevent the cultivation of crops and lead to a low livestock yield. The carbohydrate rich diet of the Angolan population is low in minerals and vitamins, resulting in various deficiency syndromes and a high child mortality rate. Eight traditionally utilized plants (Anisophyllea quangensis, Annona stenophylla subsp. cuneata, Canarium schweinfurthii, Eugenia malangensis, Landolphia lanceolata, Raphionacme madiensis, Tristemma mauritianum, Vitex madiensis subsp. madiensis) with nutritional value for the Angolan population were analyzed for their soil and growing conditions. The species are adapted to the local conditions and can serve as crops for the unfavorable soils of the province Uíge. Chemical and physical characteristics of the uppermost soil (0–5 cm) and in 30 cm depth were analyzed. The plant-available macro-and micronutrients were determined using Mehlich 3 extraction. Data are completed with leaf tissue analyses, examining the uptake of minerals. As aluminum (Al) and manganese (Mn) are plant-available in high amounts, local plants evolved mechanisms dealing with those metals. These Al accumulators with foliar contents above 1000 mg/kg are Anisophyllea quangensis (7884 mg/kg), Landolphia lanceolata (6809 mg/kg), Tristemma mauritianum (4674 mg/kg), and Eugenia malangensis (13,989 mg/kg). All four species bear edible fruits with nutritional potential. The domestication and commercialization of those plants seem to be promising, utilizing local soils without expensive amelioration techniques.
Penerapan Peta Kendali Neutrosophic Exponentially Weighted Moving Average (NEWMA) X dalam Monitoring Rata-Rata Proses Ketebalan Kaca
Authors: Wibawati Wibawati , Rahma Widya Amalia , Ahsan Muhammad , Udiatami Wilda Melia 
Published: January 2022

In the industrial sector, the measurement results of a quality characteristic often involve an uncertainty interval (interval indeterminacy). This causes the classical control chart to be less suitable for monitoring quality. Currently, a control chart with a neutrosophic approach has been developed. The neutrosophic control chart was developed based on the concept of neutrosophic numbers with control charts. One of the control charts that have been developed to monitor the mean process is the Neutrosophic Exponentially Weighted Moving Average (NEWMA) X control chart. This control chart is a combination of neutrosophic with classical EWMA control chart. The neutrosophic control chart consists of two control charts, namely lower and upper, each of which consists of upper and lower control limits. Therefore, NEWMA X is more sensitive to detect out-of-control observations. In this research, the NEWMA X control chart will be used to monitor the average process of the thickness of the panasap dark grey 5mm glass produced by a glass industry. Through the analysis in this research, it was found that by using weighting λN [0, 10; 0, 10] and constant value kN [2, 565; 2, 675], the average process of the thickness of panasap dark grey 5mm glass has not beet controlled statistically because 21 observations were identified that were outside the control limits (out of control). When compared with the classical EWMA control chart with the same weighting λ, 17 observations were detected out of control. This proves that the NEWMA X control chart is more sensitive in detecting observations that are out of control because the determination of the in-control state is based on two values, lower and upper, both at the lower and upper control limits.
Age-associated features of the development of fibrosis and inflamaging in patients with arterial hypertension and ischemic stroke
Authors: Осипова О.А. , Гостева Е.В. , Белоусова О.Н. , Жернакова Н.И. , Клюшников Н.И. , Головина Н.И. 
Published: January 2022

В статье рассмотрены вопросы развития фиброза и иммунного воспаления у больных артериальной гипертензией (АГ) с острым ишемическим инсультом (ИИ) в пожилом возрасте. Цель исследования - изучение возраст-ассоциированных особенностей концентрации маркеров фиброза (металлопротеиназы-9, тканевого ингибитора матриксных металлопротеиназ-1, их соотношения ММП-9/ТИМП-1), иммунного воспаления (TNF-α, IL-1β, INF-γ) у больных АГ с ИИ. В исследование были включены 86 больных АГ II степени, из которых 42 человека - среднего возраста (53±5 лет) и 44 - пожилого (66±5 лет), контрольную группу составили 22 пациента пожилого возраста с АГ без ИИ в анамнезе. Критерии включения - пациенты с АГ, поступившие в стационар в остром периоде первого церебрального инсульта. Установлено, что у пожилых больных АГ с ИИ показатели инфламэйджинга и маркеры фиброза были достоверно выше, чем у лиц среднего возраста. Уровень IL-1β был выше на 31,7 % (р<0,01), TNF-α - на 55,7 % (р<0,001), INF-γ - на 36,6 % (р<0,01), уровень ММП-9 - на 46,4 % (р<0,01), ТИМП-1 - на 21,2 % (р<0,01), ММП-9/ТИМП-1 - на 19,6 % (р<0,01) в пожилом возрасте по сравнению с больными среднего возраста с АГ и острым ИИ. Таким образом, установлено, что больные АГ с ИИ имеют нарушения процессов инфламейджинга, синтеза и деградации внеклеточного матрикса, особенно выраженные в пожилом возрасте.
The article deals with the development of fibrosis and immune inflammation in patients with arterial hypertension and acute ischemic stroke in old age. The aim of the study was to study age-associated features of the concentration of fibrosis markers (metalloproteinase-9, tissue inhibitor of matrix metalloproteinases-1, their ratio MMP-9/TIMP-1), immune inflammation (TNF-α, IL-1β, INF-γ) in patients with arterial hypertension and ischemic stroke (AI). The study included 86 patients with arterial hypertension (AH) of the 2nd degree, of which 42 were middle-aged (53±5 years) and 44 elderly (66±5 years). The control group consisted of 22 elderly patients with AH without a history of AI. The criteria for inclusion in the study are patients with hypertension who were admitted to the hospital in the acute period of the first cerebral stroke. It was found that in elderly patients with hypertension with AI, the indicators of inflamaging and fibrosis markers were significantly higher than in middle-aged people. The level of IL-1β was 31,7 % higher (p<0,01), TNF-α by 55,7 % (p<0,001), INF-γ by 36,6 % (p<0,01), the level of MMP-9 was 46,4 % higher (p<0,01), TIMP-1 by 21,2 % (p<0,01), MMP-9/TIMP-1 by 19,6 % (p<0,01) in the elderly compared to middle-aged patients with hypertension and acute AI. Thus, it was found that patients with arterial hypertension and ischemic stroke have violations of the processes of inflamaging, synthesis and degradation of the extracellular matrix, especially pronounced in old age.
PERAN DINAS SOSIAL DALAM PENANGANAN ODGJ ( ORANG DENGAN GANGGUAN JIWA ) KECAMATAN POLEWALI KABUPATEN POLEWALI MANDAR
Authors: Tenri Andi 
Published: January 2022

Peran Dinas Sosial Dalam Penanganan Orang Dengan Gangguan Jiwa (ODGJ) Kecamatan Polewali Kabupaten Polewali Mandar”. Di bimbing oleh Ibu Nur Fitrah selaku Pembimbing I dan Bapak Abdul Khalik selaku pembimbing II.Penelitian ini bertujuan untuk mengetahui 1.Bagaimana peran dinas sosial dalam penanganan ODGJ di Kecamatan Polewali Kabupaten Polewali Mandar, 2. Faktor penghambat dalam penanganan ODGJ di Kecamatan polewali Kabupaten Polewali Mandar.Jenis penelitian ini bersifat kualitatif yang jenis penelitiannya tidak menggunakan prosedur perhitungan atau angka-angka dan tidak menggunakan alat ukur, Metode kualitatif ini hanya memaparkan suatu peristiwa atau kejadian.Sumber data yang digunakan adalah sumber primer yaitu informasi yang bersumber dari pengamatan langsung lokasi penelitian dengan cara observasi dan wawancara.Hasil penelitian menunjukkan bahwa Peran Dinas Sosial dalam penanganan penderita ODGJ belum maksimal, Selain itu Dinas Sosial telah menjalankan perannya dalam penanganan Penyandang ODGJ di Kecamatan Polewali yaitu dengan memfasilitasi para Penyandang ODGJ seperti memberikan bantuan berupa sembako dan obat-obatan. Sehingga peran-peran yang dilakukan Dinas Sosial dalam penanganan Penyandang ODGJ dari segi jumlah penerima bantuan sosial dapat dikatakan meningkat walaupun tidak dengan jumlah yang signifikan. Faktor penghambat dalam penanganan ODGJ yaitu belum adanya wadah atau tempat rehabilitasi di Kabupaten Polewali Mandar untuk menampung ODGJ guna membina pribadi mereka agar menjadi lebih baik dan belum adanya Perda yang mengatur ODGJ.
The Highwaymen from the Great Sultan Road: the Fight of the Grand Vizier against the Cilicia’s Derebeys during the Campaign against Napoleon Bonaparte of 1799
Authors: Кобищанов Т.Ю. 
Published: January 2022

Османское противостояние вторжению Франции в Египет и Сирию 1798–1801 гг. является одним из наименее изученных сюжетов Наполеоновских войн. Проведенные великим визирем Йусуфом Зия-пашой кампании 1799–1800 и 1801 гг. продемонстрировали как слабость османской армии, так и кризис административно-политического управления империей. Европейские, в том числе и российские наблюдатели могли воочию убедиться, как султанские войска оказались бессильны не только освободить захваченный противником Египет, но и совладать с деребеями – главарями господствовавших в Анатолии разбойничьих шаек. Представленная статья посвящена феномену появления анатолийских деребеев и драматичной борьбе с ними Йусуфа Зия-паши в 1799 г.
The Ottoman resisting the invasion of France to Egypt and Syria in 1798–1801 is one of the least studied plots of the Napoleonic wars. The campaigns of 1799–1800 and 1801, conducted by the Grand Vizier Yusuf Zia-pasha demonstrated both the weakness of the Ottoman army and the crisis of administrative and political management of the Empire. European observers, including Russian ones, could convince with their own eyes how the Sultan’s troops were powerless not only to liberate Egypt captured by the enemy, but also to defeat the Derebeys, the leaders of bands of robbers that dominated in Anatolia. The presented article is devoted to the phenomenon of Anatolian Derebeys and to Yusuf Zia-pasha’s fighting against them in 1799.
The New World From an American Viewpoint
Authors: Лефко Т. 
Published: January 2022

Мир меняется, время доминирования Америки проходит. Россия, Китай и Штаты вступают в новые взаимоотношения. Природа технологий и инвестиций определяет никогда ранее в истории не встречавшиеся критерии социального, политического и военного превосходства. Технические возможности растут вне зависимости от роста моральной ответственности.Притязания Америки на лидерскую позицию подвергаются сомнению, в тот же момент, когда сомнению подвергается и власть внутри страны. Статус России, как одной из крупнейших военных держав, оспаривается. Стремление Китая к господству наталкивается на внутренние преграды — зависимость от импорта ресурсов, реакцию инициативы «Один пояс и один путь», экономическое давление. Основополагающий принцип доминирования демократического устройства общества под вопросом из-за повсеместного распространения авторитарных форм правления.Планирование стабильного развития перешло в разряд категорий теории сложности.Новые задачи -- контроль климата, пандемия, кибер-угрозы, негосударственные террористические группировки, внутренние экономические раздоры -- вместе не позволяют выработать действующий сценарий стабильного развития.Традиционные политические, экономические и религиозные учения не дают ответы на заданные обществом вопросы.В статье обсуждаются эти факторы и описываются сложности, с которыми сталкиваются Россия, Китай и Соединенные Штаты.
As the world shifts from an American-dominated presence, the roles of Russia, China and the US enter a new relationship. The nature of technology and investment will determine social, political, and military power, in a form not previously viewed in history.Technological capability develops at an unrelated pace to moral considerations.American assumptions of continuing world leadership are being challenged at the very moment when internal American governance is being challenged.Russian desires to remain an international force are questioned in many quarters.Chinese desires for world leadership face internal issues of resource dependency, reaction to the Belt and Road Initiatives, and economic pressures. The basic issue of democratic governance is under threat from growing worldwide authoritarianism.Planning for stability has entered a realm of complexity theory, with challenges such as climate control, pandemics, cyber threats, terrorism by non-state actors,and growing internal economic divisions do not allow a clear theory for guaranteed growth and abundance.Traditional political, religious and economic theories have not provided answers to a world which seeks solutions.The article discusses these factors and describes the difficulties facing Russia, China, and the United States.
Effect of reactive gas condition on nonpolar AlN film growth on MnS/Si (100) by reactive DC sputtering
Authors: Morita Masaya , Ishibashi Keiji , Takahashi Kenichiro , Ueda Shigenori , Chen Jun , Tatejima Kota , Chikyow Toyohiro , Ogura Atsushi , Nagata Takahiro 
Published: January 2022

Abstract
The effects of reactive gas flow conditions on nonpolar AlN film growth on MnS/Si (100) substrates using reactive DC magnetron sputtering were investigated. During AlN deposition at a substrate temperature of 750 °C, the MnS surface can be unintentionally nitrided, resulting in a decrease in the crystallinity of the AlN. Low-temperature growth of the AlN layer at 300 °C prevents this nitridation and results in the crystallization of nonpolar AlN. A N2 flow equal to 30% of the Ar sputtering gas flow was found to improve the crystallinity of the nonpolar AlN and to reduce nitrogen defects, which play an important role in interfacial reactions. Nitrogen defects promote the formation of alloys such as AlMn and MnSi that degrade the interface and can significantly decompose the MnS. A higher proportion of N2 improves the nonpolar AlN crystallinity, reduces the concentration of defects and suppresses reactions at the AlN/MnS interface.
Characterization of epitaxial CVD graphene on Ir(111)/α-Al2O3(0001) by photoelectron momentum microscopy
Authors: Hashimoto Eri , Tamura Keigo , Yamaguchi Hayato , Watanabe Takeshi , Matsui Fumihiko , Koh Shinji 
Published: January 2022

Abstract
We characterized CVD-grown graphene with high single-crystallinity on Ir(111)/α-Al2O3(0001) by photoelectron momentum microscopy. A multi-functional photoelectron momentum microscope (PMM), which is installed with element-specific valence band photoelectron spectroscopy and X-ray absorption spectroscopy, is a complementary characterization tool to conventional methods, such as Raman spectroscopy and atomic force microscopy, for comprehensive and quantitative characterization of graphene/Ir(111). Using PMM, we characterized the properties of CVD-grown graphene including the single-crystallinity, number of layers, crystal orientation, and degree of interaction between graphene and Ir(111) and clarified the relationship between these properties and the CVD growth conditions.
On the rigidity of four hundred Pickering-stabilised microbubbles
Authors: Anderton Nicole , Carlson Craig S. , Matsumoto Ryunosuke , Shimizu Ri-ichiro , Poortinga Albert T. , Kudo Nobuki , Postema Michiel 
Published: January 2022

Abstract
This study explores the rigidity of Pickering-stabilised microbubbles subjected to low-amplitude ultrasound. Such microbubbles might be suitable ultrasound contrast agents. Using an adapted Rayleigh–Plesset equation, we modelled the dynamics of microbubbles with a 7.6-N m−1 shell stiffness under 1-MHz, 0.2-MPa sonication. Such dynamics were observed experimentally, too, using high-speed photography. The maximum expansions were agreeing with those predicted for Pickering-stabilised microbubbles. Subjecting microbubbles to multiple time-delayed pulses yielded the same result. We conclude that Pickering-stabilised microbubbles remain very stable at low acoustic amplitudes.
Pengaruh Model Discovery Learning terhadap Motivasi dan Hasil Belajar Siswa di Sekolah Dasar
Authors: Primantiko Retno , Asrul Asrul , Tiro Abdul Rachman 
Published: January 2022

Penelitian ini bertujuan untuk mengetahui Pengaruh Model Pembelajaran Discovery Learning Terhadap Motivasi dan Hasil Belajar IPA Siswa Kelas IV SD Inpres 12 Kabupaten Sorong. Penelitian ini adalah penelitian eksperimen, dengan desain nonequivalent control group design. Hasil data yang didapat pada penelitian ini selajutnya diuji normalitas dan homogenitasnya sebagai uji prasyarat untuk melakukan uji hipotesis. uji hipotesis yang digunakan independent sampel t-test dan n-gain. Berdasarkan hasil analisis data diketahui bahwa (1) terdapat pengaruh model pembelajaran discovery learning terhadap motivasi belajar IPA siswa kelas IV SD Inpres 12 Kabupaten Sorong dengan nilai thitung (4.308) > ttabel (1.685) pada taraf signifikansi 5%. (2) terdapat pengaruh model pembelajaran discovery learning terhadap hasil belajar IPA siswa kelas IV SD Inpres 12 Kabupaten Sorong dengan nilai nilai thitung (3.574) > ttabel (1.685) pada taraf signifikansi 5%. Sehingga dapat disimpulkan model pembelajaran Discovery Learning memberikan pengaruh terhadap peningkatan motivasi dan hasil belajar siswa pada mata pelajaran IPA SD Inpres 12 Kabupaten Sorong.
Pendekatan Konstruktivisme dalam Pembelajaran Tematik Terpadu di SD Negeri Sumogawe 01 Kab. Semarang
Authors: Nuryati Nuryati , Fauziati Endang 
Published: January 2022

Penelitian ini bertujuan untuk menganalisis Pendekatan Kontruksivisme dalam Pelaksanaan Pembelajaran Tematik Terpadu di SD Negeri Sumogawe 01, Kab.Semarang. Metode yang digunakan dalam penelitian ini adalah deskriptif kualitatif. Penelitian ini dilakukan pada guru dan peserta didik. Teknik pengambilan data yang digunakan adalah observasi, wawancara dan dokumentasi. Instrument Analisis data dilakukan dengan (1) Reduksi data; peneliti melakukan proses pemilihan atau seleksi, pemusatan perhatian atau pemfokusan, penyederhanaan, dan pengabstraksian dari semua jenis informasi yang mendukung data penelitian, (2) Sajian data; sekumpulan informasi yang memberi kemungkinan kepada peneliti untuk menarik simpulan dan pengambilan tindakan, (3) Penarikan Simpulan/Verifikasi; Peneliti harus berusaha menemukan makna berdasarkan data yang telah digali secara teliti, lengkap, dan mendalam. Teknik penilaian untuk memeriksa keabsahan data menggunakan triangulasi. Triangulasi yang digunakan triangulasi sumber dan triangulasi metode. Hasil penelitian ini menunjukkan bahwa (1) Pendekatan kontruksivisme untuk memadukan muatan pelajaran menjadi satu tema, (2) Guru dapat menanamkan pemahaman peserta didik tentang pembelajaran tematik, (3) Pembelajaran tidak hanya berpusat pada guru, tetapi mengaktifkan peserta didik untuk belajar. Kesimpulan Aliran konstruktivisme berpandangan bahwa belajar merupakan hasil konstruksi peserta didik terhadap pengalaman belajarnya.