bluuebunny/crossref_metadata_2025_split huggingface dataset:
Deep Learning of ECG Waveforms for Diagnosis of Heart Failure With a Reduced Left Ventricular Ejection Fraction
Authors: Choi JungMin , Lee Sungjae , Chang Mineok , Lee Yeha , Oh Gyu Chul , Lee Hae-Young 
Published: February 2022

Abstract
The performance and clinical implications of the deep learning aided algorithm using electrocardiogram of heart failure (HF) with reduced ejection fraction (DeepECG-HFrEF) were evaluated in patients with acute HF. The DeepECG-HFrEF algorithm was trained to identify left ventricular systolic dysfunction (LVSD), defined by an ejection fraction (EF) <40%. Symptomatic HF patients admitted at Seoul National University Hospital between 2011 and 2014 were included. The performance of DeepECG-HFrEF was determined using the area under the receiver operating characteristic curve (AUC) values. The 5-year mortality according to DeepECG-HFrEF results was analyzed using the Kaplan-Meier method. A total of 690 patients with contributing 18,449 ECGs were included (mean age 67.8±14.4 years; men, 56%). HFrEF (+) identified an EF <40% and HFrEF (-) identified EF ≥40%. The AUC value was 0.844 for identifying HFrEF among patients with acute HF. Those classified as HFrEF (+) showed worse survival than HFrEF (-) (log-rank p<0.001). The DeepECG-HFrEF algorithm can discriminate HFrEF in a real-world HF cohort with excellent performance. HFrEF (+) was associated with higher mortality. The DeepECG-HFrEF algorithm may help the identification of LVSD and of patients at risk of worse survival in resource-limited settings.
Evolution Behaviour of Breathers and Lump-N-Solitons (N → ∞) for the (2+1)-Dimensional Benjamin-Bona-Mahony-Burgers Equation
Authors: li longxing 
Published: February 2022

Abstract
Several types of exact solution of the (2+1)-dimensional Benjamin-Bona-Mahony-Burgers (BBMB) equation will be reported in this research. On the basis of bilinear neural network method (BNNM), some specifific activation functions are precisely taken into the single hidden layer neural nework model, different forms of breather wave solutions, lump solutions and novel hybrid solutions are proposed. By means of symbolic computation and making use of Mathematica software, exact breather wave solutions, lump solutions and lump-N-soliton solutions are constructed completely. The obtained results enrich the knowledge of BBMB equation in the current studies. Various fifigures are plotted to exhibit the interesting evolution characteristic of theses waves vividly. The proposed methods effffectively enable us to understand and investigate the nonlinear evolution equations in plasma physics, oceanography, optical fifibers and flfluid mechanics.
First Agroinoculation System Development of Sweet Potato Symptomless Virus on Nicotiana Benthamiana
Authors: Ho Phuong T. , Byun Hee-Seong , Vo Thuy T. B. , Lal Aamir , Kil Eui-Joon , Lee Sukchan 
Published: February 2022

Abstract
Sweet potato symptomless virus 1 (SPSMV-1) is a single-stranded circular DNA virus, belonging to genus Mastrevirus, family Geminiviridae. It was first identified in the Korean peninsula in 2012 in asymptomatic sweet potato plants. Although SPSMV-1 cannot induce any significant symptoms in sweet potato plants, its co-infection with different sweet potato viruses is so prevalent that it can pose a threat to sweet potato production in Korea by the formation of a new virus through recombination events. The complete genome sequence of SPSMV-1 Korean isolate was obtained through rolling circle amplification (RCA)from sweet potato samples collected in the field (Suwon, Korea). 1.1-mer SPSMV-1 infectious clone was constructed, cloned into the plant expression vector pCAMBIA1303 and transformed into Nicotiana benthamiana with the support of the three most commonly used agrobacteria strains, GV3101, LBA4404 and EHA105. No differences were observed between the mock and inoculated groups; however, polymerase chain reaction (PCR) results showed that the virus can enter the cells and travel from the infected area to the roots, stems, and newly produced leaves. The LBA4404 Agrobacterium strain showed the highest ability to transfer the SPSMV-1 genome to N. benthamiana. Through strand-specific amplification using virion-sense- and complementary-sense- specific primer sets, we confirmed virus replication in N. benthamiana samples. This is the first study on the infectious clone construction of SPSMV-1; hence, our research contributes toward gaining a better insight into virus-plant interactions and the biological significance of this virus in infected plants.
Serverless Cloud-based Speed Advisory Application for Connected Vehicles – Case Study
Authors: Deng Hsien-Wen , Salek M Sabbir , Rahman Mizanur , Chowdhury Mashrur , Shue Mitch , Apon Amy W. 
Published: February 2022

Abstract
In this study, we develop a real-time connected vehicle (CV) speed advisory application, which we refer to as “Serverless CloSA”, using commercial cloud services and present case studies for a signalized corridor for different roadway traffic conditions. First, we develop a highly scalable serverless cloud computing architecture using Amazon Web Services (AWS) to support the requirements of a real-time CV application. Second, we develop an optimization-based real-time CV speed advisory algorithm that is deployable in the cloud. Third, we develop a cloud-in-the-loop simulation testbed using AWS and an open-source microscopic roadway traffic simulator called Simulation of Urban Mobility (SUMO). Then, we conduct three case studies for three different roadway traffic conditions, i.e., low, medium, and high-density traffic. Our analyses show that Serverless CloSA can reduce the average stopped delays at signalized intersections in a corridor by 77% while reducing the aggregated risk of collision by 21% compared to the baseline scenario, i.e., no speed advisory for the CVs. Our experiments show an average end-to-end delay of 452 ms, which is well under the 1000 ms delay threshold of real-time CV mobility applications. Thus, this study also demonstrates the feasibility of deploying a real-time CV mobility application using commercial cloud services.
Cost-Effectiveness Analysis Of Plant Versus Antibiotic Regimens In Treating Patients With Helicobacter Pylori (H. Pylori) Infection In The South Of Iran
Authors: Faramarzi Hossein , Khajoei Zahra , Lotfi Farhad , Rezaee Mehdi , Emadi Mehrnoosh , Keshavarz Khosro 
Published: February 2022

Abstract
Background: Helicobacter pylori infection is highly prevalent worldwide and affects more than half of the world's population. A variety of treatment regimens to eliminate H. pylori infection have been evaluated, but choosing the best treatment method that results in the most eradication at the lowest cost is one of the challenges facing physicians. Therefore, the present study aimed at analyzing the cost-effectiveness of using different methods to treat H. pylori in southern Iran. Methods: This study was a cost-effectiveness analysis conducted on 132 patients with H. pylori who referred to Shahid Motahari Clinic in Shiraz. The study was carried out in 2020 to evaluate two drug treatment strategies, including antibiotics (pantoprazole 40 mg, Bismuth subcitrate 108 mg, tetracycline 500 mg, and metronidazole 200 and 400 mg) and plants (Supermint Barij soft capsules 20 mg, Alium S garlic tablets 400 mg, and Green Teadin (green tea) tablets 500 mg). The patients were randomly divided into two groups, 64 of whom received an antibiotic regimen and 68 patients given a plant regimen. The success rate of clinical trials in each treatment method was determined as the clinical outcome. This study was conducted from a community perspective and therefore, direct and indirect costs were included. A data collection form was also used to collect the cost and effectiveness data. In addition, a one-way sensitivity analysis was performed to measure the robustness of the results. The data were analyzed using TreeAge Pro 2011 and Excel 2016 software. Results: The results showed that antibiotic treatment was cheaper and more effective than plant treatment and was the dominant strategy. The mean costs in the antibiotics and plant groups were $446.14 and $477.81, respectively, and the effectiveness was 0.625% and 0.382%. In addition, the one-way sensitivity analysis confirmed the robustness of the study results. Conclusion: The results showed that the use of antibiotics was a cost-effective and dominant strategy compared to plant treatment and could be suggested as a better alternative to a wide range of patients with Helicobacter pylori infection.
A Prospective Study of Minimally Invasive Anterolateral Approach in the Supine Position Versus Direct Anterior Approach Total Hip Arthroplasty. Early results
Authors: Liu Hongwen , Yin Li , Li Jiao , Liu Shaojiang , Tao Qifeng , Xu Jie 
Published: February 2022

Abstract
Background
Both of Minimally Anterolateral Approach (MIS-ALA) and Direct Anterior Approach (DAA) have been reported to be advantageous in Total Hip Arthroplasty (THA), reducing postoperative pain and permit quicker rehabilitation by preserving muscle insertions. There is little literature concern the difference of them. Therefore, we conducted a prospective study to assess the difference of early clinical outcomes, radiological, and patient-reported outcomes between the two minimally invasive approaches of MIS-ALA and DAA.
Methods
The subjects were 98 patients, with 50 in the MIS-ALA group and 48 in the DAA group. Patients with complete data were evaluated preoperatively and postoperatively at 2, 6 and 12 weeks. Clinical measurements including the ability to climb stairs and walk, a 6 minutes walk test (6MWT) distances, the Forgotten Joint Scale (FJS-12), Japanese Orthopaedic Association (JOA) Hip scores, radiological evaluation, and complications data were collected.
Results
There were no significant differences in clinical outcomes and implant alignments between MIS-ALA and DAA groups. In regards to patient-reported outcomes, the FJS-12 was significantly higher in the MIS-ALA group than in the group DAA at 2 and 6 weeks postoperatively. However, there was no significant difference in the FJS-12 between the two groups at 12 weeks after surgery. The differences also included shorter operative times, less blood loss, lower Hb drop, and fewer blood transfusions in the MIS-ALA group. The incidence of lateral femoral cutaneous nerve (LFCN) neuropraxia after surgery was 7 (14.6%) in the DAA group, zero occurred in the MIS-ALA group. One fracture was identified with each group and managed conservatively.
Conclusion
Both MIS-ALA and DAA approaches yielded excellent and similar early clinical outcomes. However, better patient-reported outcomes could be achieved by MIS-ALA THA. The MIS-ALA was a safer approach for shorter operative times, less blood loss, lower Hb drop, fewer blood transfusions and LFCN neuropraxia compared with DAA. A longer follow-up is needed to examine differences between these procedures.
Sensitivity of SnO2 nanoparticles/reduced graphene oxide hybrid to NO2 gas: A DFT study
Authors: Abdulridha Shaima K. , Abdulsattar Mudar Ahmed , Hussein Mohammed T. 
Published: February 2022

Abstract
The sensitivity of SnO2 nanoparticles/reduced graphene oxide hybrid to NO2 gas is discussed in the present work using density functional theory (DFT). The SnO2 nanoparticles shapes are taken as pyramids, as proved by experiments. The reduced graphene oxide (rGO) edges have oxygen or oxygen-containing functional groups. However, the upper and lower surfaces of rGO are clean, as expected from the oxide reduction procedure. Results show that SnO2 particles are connected at the edges of rGO, making a p-n heterojunction with a reduced agglomeration of SnO2 particles and high gas sensitivity. The DFT results are in good agreement with the experimental characterization of both SnO2 and rGO using energy gap and XPS values. Gibbs free energy, enthalpy, and entropy of the various considered reactions are calculated. Results show that the sensitivity of the rGO/SnO2 hybrid to NO2 gas is the result of the interplay of the dissociation and oxidation reactions of NO2 gas.
Updated Seismic Hazard Assessment Evaluation for the City of Aqaba, Jordan
Authors: Qadan Hani Abdel-karim , Tarazi Eid Al , Jaradat Rasheed 
Published: February 2022

Abstract
This study aims to determine seismic hazard in Aqaba city which is located in the southern part of Jordan at the Gulf of Aqaba. Nineteen active seismic area sources are considered in this study. The seismic sources within a circle of 300 km radius covering the faults to determine the Peak Ground Acceleration (PGA) and Response Spectra curves for different return periods (475, 975, and 2475 years) for nine selected sites in Aqaba city was considered. These nine sites represent different soil profiles of the city. It is resulted that 95% of the seismic hazard of the studied area is due to the sources lies within the influence circle (i.e., 300 km). The calculated PGA value for 10% of being exceeded in 50 years (i.e., return period=475 years) is 0.3g, meanwhile it is considered in the Jordan Building Code for Seismic Resisting Design (JBC) as 0.2g. Furthermore, the PGA for 5 % (return period=975 years) and 2% (return period=2475 years) are 0.45g and 0.52g, respectively. The results for soil profiles hard rock (SA), and stiff soil (SD) for periods 0, 0.2, and 1 second were 0.3g, 0.7g, 0.2g, and 0.35g, 0.79g, 0.2g (for return period of 475 years) respectively. It is noted that the maximum spectral acceleration is 0.87g at Aqaba southern coast for stiff soil profile, while its minimum value is 0.7g at the northern part of Aqaba for stiff soil profile for return period 475 years.
Effect of Iron Oxide Nanoparticles on the Thermal Characteristics of Supramolecular, Dendritic and Macromolecular Capping Agents
Authors: Philip Sherin , Kuriakose Sunny 
Published: February 2022

Abstract
The present study aimed at the enhancement of the thermal characteristics of different capping agents belonging to different macromolecular families, with the incorporation of iron oxide nanoparticles. Iron oxide nanocomposites were prepared following a simple reduction protocol using sodium borohydride (NaBH4) succeeded by air oxidation. Three iron oxide composites were prepared using different biocompatible capping agents. The capping agents used in the present study were supramolecular β-cyclodextrin, dendritic hyperbranched polyglycerol and macromolecular starch. The chemical nature of the composites was successfully confirmed by spectroscopy. The well characterized composite systems were studied for their thermal characteristics using TG/DTG and DSC measurements. The primary focus of the study was to analyse any change in the thermal behaviour of the pure encapsulating systems on incorporation with the iron oxide species. The analysis was conducted by comparing the TG/DTG and DSC measurements of the pure capping agents- cyclodextrin, hyperbranched polyglycerol and starch with their respective nanoparticle incorporated composites.
Prevalence Of Depression And Associated Factors Among Patients Attending Orthopeadic Outpatient Clinics At Hospitals Of Wolaita, Southern Ethiopia.
Authors: Minda Adanech , Workie Shimelash Bitew , Leka Cherinet , Worku Dawit 
Published: February 2022

Abstract
Background: Psychiatric disorders and behavioral disturbances are reported to be three to five times more common among people with injuries. Depressive disorders are the common reported psychiatric problem among trauma survivors. The aim was to assess the magnitude of depression and associated factors among orthopedic trauma patients attending Wolaita Sodo town hospitals.Methods: A facility-based cross-sectional study was conducted with 359 systematic randomly sampled orthopedic patients. A structured questionnaire was used for data collection. The data were analyzed using SPSS version 20. The bivariate analysis was done and all explanatory variables which have an association with the outcome variable at p-value <0.25 were selected for multivariable analysis. Variables that were statistically significant at P-value <0.05 were declared using an adjusted odds ratio with a 95% confidence interval. Result: A total of 352 orthopedic patients were responded which makes a 98% response rate. More than half, 193(54.8%) of respondents were male. Overall depression among respondents was 36.4% with 95% CI [31.4, 41.4]. Pain (AOR 4.42; 95%CI [1.49, 13.1]), complication (AOR 5.6 [95% CI 3.02, 10.38]), amputation (AOR 3.2 (95% CI [1.64, 6.1]) and multiple site injury (AOR 2.6 [95% CI 1.005, 6.64]) had statistically significant association with depression.Conclusion and Recommendation: - Depressive disorders are a common phenomenon among orthopedic patients. Having pain, having complications, being amputated, and having multiple site injuries were predictors of depression. Clinicians working at orthopedic clinics emphasize patients' psychological state during the evaluation, especially for amputated patients, and those having multiple site injuries, develop a complication, patients who undergo amputation, and those patients with severe pain.
Anti-inflammatory actions of β-funaltrexamine in a mouse model of lipopolysaccharide-induced inflammation.
Authors: Myers Stephanie , McCracken Kelly , Buck Daniel , Curtis J. Thomas , Davis Randall 
Published: February 2022

Abstract
Neuroinflammation is involved in a wide range of brain disorders, thus there is great interest in identifying novel anti-inflammatory agents to include in therapeutic strategies. We previously determined that lipopolysaccharide (LPS)-induced sickness behavior and neuroinflammation in mice are prevented by pretreatment with beta-funaltrexamine (β-FNA), a selective mu-opioid receptor (MOR) antagonist. Herein we investigated the temporal importance of β-FNA treatment in this pre-clinical model of LPS-induced neuroinflammation. Adult, male C57BL/6J mice were administered LPS followed by treatment with β-FNA immediately or 4 h post-LPS. Sickness behavior was assessed using an open-field test, followed by assessment of inflammatory signaling in the brain, spleen, and plasma. Levels of inflammatory chemokines/cytokines (interferon γ-induced protein, CXCL10; monocyte chemotactic protein 1, CCL2; and interleukin-6, IL-6) in tissues were measured using an enzyme-linked immunosorbent assay and nuclear factor-kappa B (NFκB), p38 mitogen activated kinase (p38 MAPK), and glial fibrillary acidic protein (GFAP) expression were measured by western blot. LPS-induced sickness behavior and chemokine expression were inhibited more effectively when β-FNA treatment occurred immediately after LPS administration, as opposed to 4 h post-LPS; and β-FNA-mediated effects were time-dependent as evidenced by inhibition at 24 h, but not at 8 h. The inhibitory effects of β-FNA on chemokine expression were more evident in the brain versus the spleen or plasma. LPS-induced NFκB-p65 and p38 MAPK expression in the brain and spleen were inhibited at 8 and 24 h post-LPS. These findings extend our understanding of the anti-inflammatory effects of β-FNA and warrant further investigation into its therapeutic potential.
Non-Contact Thickness Measurement With EDS
Authors: Ingr Tomas , Prucek Robert 
Published: February 2022

Abstract
In this work we deal with a method of non-destructive layers thickness measurement using a scanning electron microscope (SEM) equipped with an energy dispersive spectrometer (EDS). This method was chosen for ease of use in all laboratories equipped with the SEM with the EDS detector. Unlike other techniques (e.g., atomic force microscopy, transmission electron microscopy, ellipsometry), this measurement method does not require special sample treatment and does not place such emphasis on the properties of the substrate in the measured layers. This method is able measure 2D structures, thin multi-layers created on any substrate. It is possible to measure fibers and particles (1D and 0D structures) composed of several layers (core and shell), which can be attached to the surface of non-biological material. This method uses procedures with a calibration layer or calibration spectrum. Errors in the preparation of calibration samples are mentioned, which increase the measurement inaccuracy.
Early Human Trophoblast Development: From Morphology To Function
Authors: Gauster Martin , Moser Gerit , Wernitznig Stefan , Kupper Nadja , Huppertz Berthold 
Published: February 2022

Abstract
Human pregnancy depends on the proper development of the embryo prior to implantation and the implantation of the embryo into the uterine wall. During the preimplantation phase, formation of the morula is followed by internalization of blastomeres that differentiate into the pluripotent inner cell mass lineage, while the cells on the surface undergo polarization and differentiate into the trophectoderm of the blastocyst. The trophectoderm mediates apposition and adhesion of the blastocyst to the uterine epithelium. These processes lead to a stable contact between embryonic and maternal tissues, resulting in the formation of a new organ, the placenta. During implantation, the trophectoderm cells start to differentiate and form the basis for multiple specialized trophoblast subpopulations, all of which fulfilling specific key functions in placentation. They either differentiate into polar cells serving typical epithelial functions, or into apolar invasive cells that adapt the uterine wall to progressing pregnancy. The composition of these trophoblast subpopulations is crucial for human placenta development and alterations are suggested to result in placenta-associated pregnancy pathologies. This review article focuses on what is known about very early processes in human reproduction and emphasizes on morphological and functional aspects of early trophoblast differentiation and subpopulations.
Synthesis and characterization of solid solution of Sr(Mo1-xWx)O4 crystals obtained by the sonochemical method and their sonophotocatalytic properties
Authors: de Sousa Priscila Brandão , Nogueira Içamira Costa , Gusmão Gustavo Oliveira de Meira , Gusmão Suziete Batista Soares , Lopes Francisco Henrique Pereira , Sousa Bianca Silva , Sczancoski Júlio César , Gouveia Amanda Fernandes , Cavalcante Laécio Santos 
Published: February 2022

Abstract
In this paper, the solid solution of strontium molybdate-tungstate [Sr(Mo1-xWx)O4] crystals with (x = 0; 0.25; 0.50; 0.75; and 1) were synthesized by the sonochemical method. Their structure, morphology, optical, and sonophotocatalytic (SPC) properties were evaluated as a function of the replacement of Mo6+ by W6+ cations into the lattice. Structural characterizations performed by X-ray diffraction, Rietveld refinement, micro-Raman, and Fourier transform infrared spectroscopies proved that all samples are monophasic and crystalline, with a scheelite-type tetragonal structure. Field-emission scanning electron microscopy images revealed the octahedral and dumbbell-like morphologies for SrMoO4 and SrWO4 crystals. Moreover, it was noted to pass through spindle-like morphology for the microcrystals containing both Mo6+ and W6+ cations (x = 0.25; 0.50; and 0.75). The absorption spectra obtained through ultraviolet-visible diffuse reflectance spectroscopy showed a directly proportional increase in the optical band gap (Egap) values from 4.27 to 5.01 eV. These data indicate an increase in the intermediary electronic levels between valance and conduction band with the raise of the concentration of W6+ cations in the lattice. Finally, we have found that the Sr(Mo0.25W0.75)O4 crystals displayed the best SPC activity, around 98% of the Rhodamine B dye was degraded in 240 min.