bluuebunny/crossref_metadata_2025_split huggingface dataset:
Role of Intermittent Fasting, Calorie Restriction and Autophagy in Healthy Aging: A Review of Literature
Authors: Rahman Md Shahidur , Islam Md Rafiqul 
Published: January 2022

Aging is a progressive process associated with decline in structure and function, hindered maintenance and repair systems, increased vulnerability to disease and death, and reduced reproductive capacity. Healthy aging can be prolonged by calorie limitation or by pharmacologic agents that mimic the effects of caloric restriction. Both fasting and the genetic inactivation of nutrient signaling converge on the induction of autophagy, a cytoplasmic recycling process that counteracts the age-associated accumulation of damaged organelles and proteins as it improves the metabolic fitness of cells. Holy Quran made it compulsory for all healthy adult Muslim to fast during Arabic month of Ramadan from early dawn to dusk. Believers of other religions also have the tradition of fasting as religious rituals in different way. The importance offasting and the autophagy process was highlighted very recently by Prof. Yoshinori Ohsumi, a Noble prize winner in medicine for his pioneering studies revealing the mechanisms of autophagy in baker’s yeast 30 years ago. Here we made literature search to review experimental findings on intermittent fasting (IF) and autophagy that influences the major nutrient and growthrelated signaling pathways as well as the up regulation of anti-aging pathways.
Bangladesh Journal of Neuroscience 2019; Vol. 35 (1): 39-45
Study of Rare Cases of Congenital Myasthenic Syndrome in Bangladesh
Authors: Banu Akter , Rahman Md Mahfuzer , Anwar Md Mahfuj Ul , Ahmed Raihan , Kalam Azad Md Abul , Kabir Jahangir , Ahmed Anis , Sarkar Devendranath , Jahan Shah Md Sarwer , Ohab MA , Alam Shafiul , Haque Md Ashraful , Shaheduzzaman AKM , Rahman Md Mokhlesur , Mondol Shariful Islam , Sarkar Md Kamruzzaman , Miah Md Helal , Mondol Rahenur , Rabbani Md Golam , Pondit Prosanto Kumar , Sarkar Narayan Chandro , Sarkar Md Ruhul Amin , Azad Abul Kalam , Adiluzzaman Md Al Fatah Al , Karmakar Priobrata , Sutradhar Probal , Mamoon Md Abdullah Al , Mondol Firoz , Shafiujjaman ASM 
Published: January 2022

Congenital myasthenic syndromes (CMS) comprise a heterogeneous group of rare inherited diseases in which the neuromuscular transmission in the motor plate is compromised by one or more genetic pathophysiological specific mechanisms are characterized by fatigable weakness of skeletal muscle (e.g., ocular, bulbar, limb muscles) with onset at or shortly after birth or in early childhood; rarely, symptoms may not manifest until later in childhood. The diagnosis of CMS is based on clinical findings, a decremental EMG response of the compound muscle action potential (CMAP) on low-frequency (2- 3 Hz) stimulation, absence of anti-acetylcholine receptor (AChR) and anti-MuSK antibodies in the serum, a positive response to acetylcholinesterase (AchE) inhibitors and lack of improvement of clinical symptoms with immunosuppressive therapy. Pathogenic variants in one of multiple genes encoding proteins expressed at the neuromuscular junction are currently known to be associated with subtypes of CMS. The most commonly associated genes include: CHAT, CHRNE, COLQ, DOK7, GFPT1 and RAPSN. We studied on a sibling presented with progressive fatigability and fluctuating ptosis with frequent exacerbations of muscle weakness during infections since infancy. On both cases CT scan of chest were negative for thymoma, antibodies against the acetylcholine receptor (AChR) and the muscle specific kinase (MuSK) were negative and decremental response on electrophysiological study of Repetitive nerve stimulation (RNS) and EMG were consistent with disease of neuromuscular junction (post synaptic) and they were only on pyridostigmine for long time with marked improvement of symptoms and signs. Considering all scenario both of our cases mostly fits with the autosomal recessive, post synaptic CMS associated with Rapsyn deficiency.
Objective : As in Bangladesh, there is inadequate data on the epidemiological profile of CMS, our aim is to describe these cases for their rarity and the difficulty encountered in diagnosis as they are easily confused with Juvenile Myasthenia Gravis (JMG) and familial myopathies. As both the cases are very rare, it should be an original article.
Bangladesh Journal of Neuroscience 2019; Vol. 35 (2): 95-103
Desafios éticos, metodológicos e práticos na pesquisa qualitativa em saúde: um olhar a partir de um estudo em torno do processo de morrer
Authors: Hilário Ana Patrícia , Augusto Fábio Rafael 
Published: January 2022

Partindo de uma experiência de investigação em torno do processo de morrer, este artigo procura discutir alguns dos desafios que emergiram no âmbito de uma pesquisa qualitativa de natureza etnográfica no campo da saúde. A sensibilidade do tema e a vulnerabilidade dos participantes conduziu à necessidade de criar estratégias que mitigassem potenciais efeitos indesejados para os atores envolvidos. Desta forma, discutem-se questões ético-metodológicas e o impacto que a pesquisa assumiu para os participantes e investigador. As principais conclusões apontam, por um lado, para a necessidade de criar diretrizes bem definidas no que diz respeito à pesquisa com sujeitos humanos e, por outro, para a importância de adequar os instrumentos de recolha no sentido de criar proximidade e salvaguardar o bem-estar de todos os intervenientes. Este artigo procura contribuir para um debate em torno dos “bastidores” da pesquisa, dando a conhecer dilemas transversais à investigação.
Palavras-chave: Pesquisa qualitativa; Sensibilidade; Vulnerabilidade; Ética.
Construção de tecnologia educativa para o autocuidado de pessoas com doença renal crônica em hemodiálise
Authors: Benites Gabriela de Oliveira , Figueiredo Paula Pereira de , Canuso Lenice Dutra de Sousa , Francioni Fabiane Ferreira 
Published: January 2022

O estudo teve como objetivo construir uma tecnologia educativa destinada ao autocuidado de pessoas com Doença Renal Crônica em tratamento hemodialítico sob a perspectiva da produção científica na área. Para tanto, foi realizada uma pesquisa de natureza qualitativa, do tipo descritiva e exploratória por meio de uma Revisão Integrativa. Subsequentemente construiu-se a tecnologia educativa a partir de um instrumento norteador. A coleta de dados ocorreu em janeiro de 2021 e, após a aplicação dos critérios de inclusão e exclusão, obteve-se um total de vinte e um artigos. Os resultados apontaram seis categorias temáticas mais prevalentes no que diz respeito às principais dificuldades enfrentadas por essa população a respeito de seu autocuidado, contudo, o material didático produzido integrou todas as temáticas identificadas, ainda que não tenham apresentado expressividade do ponto de vista quantitativo. A tecnologia educativa, produto deste estudo, constitui-se em uma série de cinco cartilhas que se configuram em subprodutos seriados, distintos e interdependentes. Percebe-se esse trabalho como relevante devido à temática estudada apresentar-se como um problema de saúde pública no Brasil e no mundo, que impacta na qualidade de vida das populações e que requer intervenções em saúde com vistas à promoção do autocuidado. Ademais, acredita-se que a produção do material educativo contribui para a divulgação de ações em saúde pautadas em evidências científicas e, diferente de outros formatos de produções acadêmicas, conversa diretamente com o público-alvo, oportunizando à população em geral o acesso ao conhecimento advindo de pesquisas na área da saúde.
Studi Fenomenologi Work-Family Conflict dalam Kehidupan Guru Honorer Wanita
Authors: Asbari Masduki , Pramono Rudy , Kotamena Fredson , Liem Juliana , Sihite Otto Berman , Alamsyah Virza Utama , Imelda Donna , Setiawan Samuel Tanasjah , Purwanto Agus 
Published: January 2022

Tujuan penelitian ini adalah untuk mengetahui latar belakang seorang ibu rumah tangga untuk bekerja di luar sebagai guru honorer, mengetahui kondisi finansial keluarga guru honorer wanita, dan untuk mengetahui work-family conflict yang dialami wanita selama menjadi guru honorer. Penelitian ini adalah penelitian kualitatif dengan pendekatan studi fenomenologi dengan metode pengumpulan data, yaitu wawancara, observasi dan studi literatur. Narasumber yang ada dalam penelitian ini adalah ibu rumah tangga yang bekerja di luar rumah sebagai guru honorer di Tangerang. Untuk mengetahui keabsahan data digunakan uji kredibilitas data atau kepercayaan terhadap data. Metode pengujian data menggunakan triangulasi sumber dan member check. Metode analisis data menggunakan data reduction, dan drawing conclusion. Penelitian ini menemukan bahwa faktor utama ibu rumah tangga untuk bekerja di luar rumah adalah karena faktor finansial dan pendidikan. Faktor lainnya adalah faktor mengisi waktu luang dan untuk bersosialisasi dengan rekan kerja. Solusi menangani work-family conflict dibahas mendalam dalam kajian ini.
OKE MAS (Optimalisasi Kegiatan E-learning Menjadi Aktif dan Soluktif) Upaya Peningkatan Sektor Ekonomi dan Pendidikan di Masa Pandemi
Authors: Haryadi Rudi , Al'ayubi Mochamad Wildan 
Published: January 2022

Sesuai dengan Surat Edaran Mendikbud Nomor 4 Tahun 2020 tentang pelaksanaan kebijakan pendidikan dalam masa darurat penyebaran COVID 19 mengajurkan untuk melaksanakan proses belajar dari rumah melalui pembelajaran daring, kesiapan dari pihak penyedia layanan maupun siswa merupakan tuntutan dari pelaksanaan pembelajaran daring. Tentu tidak ada yang menginginkan ini semua terjadi. Namun atas kemanusian diatas segalanya, hal ini perlu di berlakukan dengan baik agar kita semua segera terbebas dari pandemi Covid-19. Sudah seharusnya peran milenial sangat intens diperlukan dalam menciptakan ide-ide dan trobosan untuk menstabilkan segala sektor saat masa pandemi seperi saat ini. Oleh karenanya penulis mencoba memberi suatu gagasan yang mungkin bisa dijadikan solusi dalam mangatasi masalah kususnya dalam sektor ekonomi maupun sektor pendidikan. Dengan program OKE MAS (Optimalisasi Kegiatan E-learning Menjadi Aktif dan Soluktif) dengan cara memanfaatkan berbagai media aplikasi yang sedang naik daun atau viral di negara ini yang tentunya dapat menghasilkan uang seperti aplikasi Youtube dan Tiktok. Kedua aplikasi tersebut sangat memungkinkan meraup keuntungan yang dapat dimanfaatkan oleh berbagai instansi di dunia pendidikan yang nantinya bisa bermanfaat untuk membantu para siswa yang terkendala ekonomi saat pembelajaran online .

Kata Kunci: Youtube, Tiktok, Pembelajaran Online
The Effect of Blood Learning on Moral Development
Authors: Baharudin Yusup Chendi Maulana , Lestari Triana 
Published: January 2022

The influence of online or online learning one year ago has had a huge impact on education in Indonesia, which of course affects the moral development of children. During the Covid 19 pandemic it had quite a variety of impacts for everyone. The occurrence of sudden changes in daily habitats always causes emotional unpreparedness for each family member, in the development of early childhood behavior. This study involved respondents from several parents, with the data obtained using quantitative. Where respondents from several parents will be presented in the form of a table of research results. Data collection techniques using google form media. The study collected data from the results of the analysis with quantitative data analysis techniques. It can be seen that there is a policy from the government that implements online or online learning that changes all learning activities at educational institutions. Where online or online learning changes moral development in students, especially in early childhood and elementary school age.
Peranan Guru Mata Pelajaran Aqidah Dalam Menanamkan Nilai Keagamaan Pada Siswa MTs. Nurul Huda Kareng Lor Kedopok Probolinggo
Authors: Karomah Ainaul , Muhammad Devy Habibi , Susandi Ari 
Published: January 2022

Tujuan penelitian adalah; 1) untuk mengetahui aqidah dalam menanamkan nilai keagamaan pada siswa MTs Nurul Huda. 2) Untuk mengetahui upaya guru dalam menanamkan nilai keagamaan pada siswa MTs Nurul Huda. 3) Untuk mengetahui faktor penunjang dan penghambat dalam menanamkan nilai keagamaan pada siswa MTs Nurul Huda. Penelitian ini dirancang dengan pendekatan deskriptif kualitatif dengan teknik pengumpulan data berupa wawancara obeservasi dan dokumentasi. Kesimpulan dalam penelitian ini adalah; 1) Peran guru mata pelajaran aqidah akhlak di MTs. Nurul Huda dalam menanamkam nilai-nilai keagamaan telah dilakukan dengan optimal. Dengan beberapa faktor pendukung yang mumpuni. Diharapkan mampu menjadikan siswa di MTs. Nurul huda menjadi Siswa yang tidak hanya cerdas secara intelaktual maupun secara spiritual. Mengingat dengan perkembangan zaman yang sedemkiian rupa, siswa diharapkan bisa tidak mudah ikut arus zaman yang merusak masa melainkan mampu menggapai cmasa depan yang cerah. 2) Diantara faktor penunjang yang sangat mempengaruhi dalam menanamkan nilai-nilai keagamman di MTs. Nurul Huda yaitu Tenaga pendidik dan Lingkungannya. Dimana latar belakang pendidik yang didominasii oleh alumni pondok pesantren serta lingkungan yang religius mampu mewujudkan siswa menjadi insanul kamil .
Kata kunci: Guru Mata Pelajaran Aqidah, Nilai Keagamaan
Perancangan Aplikasi Sistem Akademik Berbasis Website Menggunakan Framework Codeigniter di Madrasah Diniyah Nurul Amin Jabung Probolinggo
Authors: Bahar Hasbul , Rosiqi Zainur , Arifin Syamsul 
Published: January 2022

Sistem Akademik merupakan suatu sistem yang dapat digunakan untuk mengelola data- data kegiatan sivitas akademik suatu Kelembagaan sekolah dari tingkat dasar sampai ke Perguruan Tinggi sekalipun. Sistem Aplikasi Akademik Berbasis Website Di Madrasah Diniah Nurul Amin Jabung bertujuan untuk mendukung penyelengaraan pendidikan, sehingga dari pengelolahan data tersebut akan menghasilkan data-data informasi yang lebih efisien, efektif, praktis dan berguna untuk murid, guru maupun lembaga itu sendiri untuk memajukan Akreditasi Pendidikan Di Madrasah Diniah Nurul Amin. Madrasah Diniah Nurul Amin Jabung masih menggunakan aplikasi office yang berbasis offline. Sehingga pengolahan data-data kelembagaan sekolah tersebut kurang akurat dan efesien, maka peranan sistem informasi akademik sangat dibutuhkan oleh Madrasah Diniah Nurul Amin Jabung. Dengan adanya sistem informasi akademik diharapkan bagian akademik Madrasah Diniah Nurul Amin Jabung dapat meningkatkan pelayanan terhadap para murid, guru maupun orang tua murid.
Predictive Role of Tumor-Stroma Ratio for Survival of Patients With Non-Small Cell Lung Cancer: A Meta-Analysis
Authors: Zhang Xuefeng , Ma Hongfu , Zhang Liang , Li Fenghuan 
Published: January 2022

Background: Role of tumor-stroma ratio (TSR) as a predictor of survival in patients with non-small cell lung cancer (NSCLC) remains not clear. A systematic review and meta-analysis was conducted to summarize current evidence for the role of TSR in NSCLC.Methods: Relevant cohort studies were retrieved via search of Medline, Embase, and Web of Science databases. The data was combined with a random-effect model by incorporating the between-study heterogeneity. Specifically, subgroup and meta-regression analyses were performed to explore the association between TSR and survival in patients with squamous cell carcinoma (SCC) or adenocarcinoma (AC).Results: Nine cohort studies with 2031 patients with NSCLC were eligible for the meta-analysis. Pooled results showed that compared to those stroma-poor tumor, patients with stroma rich NSCLC were associated with worse recurrence-free survival (RFS, hazard ratio [HR] = 1.52, 95% confidence interval [CI]: 1.07 to 2.16, p = 0.02) and overall survival (OS, HR = 1.48, 95% CI: 1.20 to 1.82, p &lt; 0.001). Subgroup analyses showed that stroma-rich tumor may be associated with a worse survival of SCC (HR = 1.89 and 1.47 for PFS and OS), but a possibly favorable survival of AC (HR = 0.28 and 0.69 for PFS and OS). Results of meta-regression analysis also showed that higher proportion of patients with SCC was correlated with higher HRs for RFS (Coefficient = 0.012, p = 0.03) and OS (Coefficient = 0.014, p = 0.02) in the included patients, while higher proportion of patients with AC was correlated with lower HRs for RFS (Coefficient = −0.012, p = 0.03) and OS (Coefficient = −0.013, p = 0.04), respectively.Conclusion: Tumor TSR could be used as a predictor of survival in patients with NSCLC. The relative proportion of patients with SCC/AC in the included NSCLC patients may be an important determinant for the association between TSR and survival in NSCLC. Stroma richness may be a predictor of poor survival in patients with lung SCC, but a predictor of better survival in patients with lung AC.
Kemampuan Koping Dengan Tingkat Kecemasan Klien Hipertensi
Authors: Jubaedah Jubaedah , Pratiwi Ayu 
Published: January 2022

Hypertension is often called the silent killer because it is often asymptomatic and causes complications in other organs, this often causes anxiety in people with hypertension. Coping is an attempt to overcome psychological stress, including anxiety. The purpose of this study was to determine the relationship between coping abilities and anxiety levels in patients with hypertension. The design of this study was a correlational study with a cross-sectional study approach with a sample of 100 respondents taken using a total sampling technique. The results showed that the description of hypertension sufferers in the Grogol Health Center Work Area, Cilegon City, the majority aged 45 years (63%), the majority were male (67%), the majority suffered from hypertension 5 years (60%), the majority had coping skills. maladaptive (65%) and the majority experienced moderate anxiety (43%). There is a significant relationship between coping abilities and anxiety in patients with hypertension in the Grogol Health Center Work Area, Cilegon City in 2021 (p value: 0.000).
Keywords: hypertension, anxiety, coping
Hubungan Tingkat Pengetahuan Dengan Kecemasan Ibu Hamil di Masa Pandemi Covid-19 Di Praktek Mandiri Bidan Wilayah Kerja Denpasar Selatan
Authors: Nurtini Ni Made , Purnama Dewi Komang Ayu , NorianI Ni Ketut 
Published: January 2022

ABSTRAKLatar Belakang : Pandemi COVID-19 dialami oleh seluruh negara di dunia, pelayanan kesehatan maternal dan neonatal terkena dampak baik secara akses maupun kualitas. Tujuan dari penelitian ini adalah menganalisa hubungan tingkat pengetahuan dengan kecemasan ibu hamil di masa pandemi Covid-19. Metodelogi dalam penelitian ini adalah analitik cross sectional. Populasi semua ibu hamil yang melakukan pemeriksaan kehamilan di Praktek Mandiri Bidan (PMB) Wilayah Kerja Denpasar Selatan, pada bulan Januari sampai Februari 2021. Pengambilan sample dilakukan secara incidental sampling. Jumlah sample yang digunakan 100 orang ibu hamil. Intrumen pengumpulan data dalam penelitian ini adalah kuesioner dengan google form (online). Analisa bivarite yang digunakan Spearmen Rho. Hasil penelitian ini responden paling banyak memiliki pengetahuan baik sejumlah 92 responden (92%), responden paling banyak dikategorikan normal untuk kecemasan sejumlah 96 responden (96%) dan 4 responden yang mengalami kecemasan ringan. Ada hubungan antara tingkat pengetahuan dengan kecemasan ibu hamil di masa pandemi Covid-19 dengan nilai koefisien korelasi (r)= 0,504, hal ini menunjukkan ada korelasi positif antara tingkat pengetahuan dengan kecemasan ibu hamil di masa pandemi Covid-19. Kesimpulan hasil ini penelitian ini bahwa semakin baik pengetahuan, kecemasan ibu semakin baik (normal).Kata kunci : pengetahuan, ibu hamil, kecemasan, covid-19
SELF EFFICACY MENSTRUAL HYGIENE MANAGEMENT PADA REMAJA PUTRI
Authors: Adnyanita Anak Agung Istri Citra , Suyasa I Gede Putu Darma , Mastryagung, Gusti Ayu Dwina 
Published: January 2022

ABSTRAKLatar Belakang. Remaja putri yang mengalami pubertas akan ditandai dengan adanya menstruasi. Self efficacy yang memadai akan menghasilkan perilaku yang sesuai pada manajemen kebersihan saat menstruasi.Tujuan Penelitian. Untuk mengetahui tingkat self efficacy remaja putri dalam usaha manajemen kebersihan menstruasi yang dilakukan oleh remaja putri.Metode. Penelitian ini menggunakan desain deskriptif dengan pendekatan cross sectional. Jumlah sampel yang digunakan adalah seluruh siswi kelas VII yang telah menstruasi yakni 155 responden.Hasil. Penelitian ini menunjukkan dari 155 responden terdapat 88 responden (56,8%) memiliki tingkat efikasi diri dalam manajemen kebersihan saat menstruasi yang tinggi, sementara 66 responden (42,6%) memiliki tingkat efikasi yang sedang dan 1 responden (0,6%) memiliki tingkat efikasi diri yang rendah.Kesimpulan. Mayoritas responden dalam penelitian ini memiliki tingkat efikasi diri yang tinggi dalam manajemen kebersihan saat menstruasinya. Diharapkan agar petugas kesehatan terus meningkatkan upaya untuk meningkatkan self efficacy remaja dalam pengaturan kebersihan diri selama menstruasi. ABSTRACTBackground. Teenage girls who experience puberty will be indicated by the presence of menstruation. Adequate self-efficacy resulted in adequate behavior in menstrual hygiene management. Purpose. This research aimed to determine the level of self-efficacy on menstrual hygiene management among teenage girls.Methods. This study used a descriptive design with a cross sectional approach. Respondents were 150 grade VII students who already had menstruation.Results. The results of this study showed that out of 155 respondents, 88 respondents (56.8%) had high self-efficacy in menstrual hygiene management; 66 respondents (42.6%) had moderate self-efficacy and 1 respondent (0.6%) had low self-efficacy. Conclusion. The results of this study reveal that the respondents have high self-efficacy in menstrual hygiene management. It is imperative that health care professionals continue to increase self-efficacy in menstrual hygiene management.
PENGEMBANGAN BAKAT MINAT DAN PENDIDIKAN KARAKTER DI UPTD “KAMPUNG ANAK NEGERI” SURABAYA
Authors: Josephine Roosandriantini  , Selvia Devy Tiorma  
Published: January 2022

Abundant natural resources cannot determine the success of a nation in achieving its national goals, but human resources can determine its success. In the times of globalization, Indonesian people really need to develop Human Resources (HR). Thus, character education is needed early on to be able to produce quality human resources to properly support the implementation of development programs. Indonesia often experiences crimes, injustice, corruption, and violence against children, which indirectly shows that our nation is experiencing a character crisis in the society. Therefore, our community service was held in Surabaya's Kampung Anak Negeri (Kanri) because it was necessary to train and develop the character, talent, and interests of the young people from an early age. Our research method is observing and interviewing the people of Kanri so that the community service team could design programs that could beapplied to the children in Kanri. The results of the community service are aimed to optimally develop the potentials, talents, interests, personalities, cooperation, and independence of learners.
Keywords: Character, Kanri, Interest, Surabaya