bluuebunny/crossref_metadata_2025_split huggingface dataset:
Physical fitness of students based on a test used to assess the physical fitness of soldiers of the National Reserve Forces
Authors: Jalowska Pola , Prokopczyk Adam 
Published: October 2022

Background and Study Aim. The purpose of this study was to analyze the physical fitness of students based on a test used to assess the physical fitness of soldiers of the National Reserve Forces.
Material and methods. The study included 30 students majoring in Physical Education, specializing in Physical Education in the Uniformed Services. The average age of the subjects was 23.53 years, where the youngest subject was 21.92 years old and the oldest was 28.67 years old (SD = 1.513). The National Reserve Forces (NSR – abbreviation using in Polish language) physical fitness test was used to assess the level of physical fitness of professional soldiers. Students completed a proprietary research questionnaire to investigate the level and type of additional physical activity of the subjects, their future career plans related to the uniformed services, and their level of satisfaction with their performance on the fitness tests.
Results. It was shown that students who rated their level of preparation for uniformed service and satisfaction with their performance higher scored better on the NSR test. It was proven, equally, that students having a higher weekly volume of additional physical activity obtain higher scores in the fitness test. In addition, it has been demonstrated that better results in the fitness test are achieved by students who engage in physical activity at the level of active athletes.
Conclusions. The recommendation to introduce classes similar to sports training under battlefield conditions into schools and universities preparing future uniformed officers is justified. This would give a simultaneous improvement in physical fitness along with an increase in the level of self-efficacy for combat operations. Those wishing to enter the selection process for uniformed formations should practice regular physical activity, preferably at an intensity and volume close to the competitive level. This significantly affects the result achieved in the fitness test.
The effects of experimental program on the explosive strength of lower limbs in male adolescents
Authors: Radulović Nikola , Jurišić Mila V. , Pavlović Ratko , Obradović Jelena , Mihajlović Ilona 
Published: October 2022

Background and Study Aim. Various experimental programs for the development of motor skills are present in sports activities. Explosive strength can be defined as the ability to produce maximum force as soon as possible, and it represents an essential factor in activities where it is necessary to increase the acceleration of the body mass, the mass of specific body parts, or of an external object. The aim of study – to determine the effects of an experimental program on the explosive strength of lower limbs in male adolescents.
Material and Methods. One hundred and one male adolescent (aged 19 years ± 6 months; body height 181.43 ± 7.42 cm; body mass 80.08 ± 10.07 kg) were recruited and randomly divided into two groups: experimental group (E; N=48) and control group (K; N=48). The E group performed the experimental program which lasted fifteen weeks and consisted of three 60-min training sessions per week. All participants were tested on Squat Jump (SJ), Countermovement Jump (CMJ), Countermovement Jump with arms (CMJa) and Continuous Jump with Straight Legs (CJSL). The four tests were performed using a Kistler force platform to measure Quatro Jump Bosco Protocol Version 1.0.9.2 and gave us data about the jump height, number of jumps for 15s, average power jump and peak power jump. The multivariate analysis covariance (MANCOVA) and follow up analysis covariance (ANCOVA) were used to analyze the data.
Results. The results of MANCOVA showed statistically significant differences (p ≤ 0.001) between the E and K groups in all systems of variable lower limb explosive strength in male adolescents. In addition, results of ANCOVA showed statistically significant differences (p ≤ 0.001) in SJ, CMJ, CMJa and CJSL in favor of the E group compared to the K one.
Conclusions. The results of this research show that a fifteen-week experimental program can lead to significant improvements in lower limb explosive strength in male adolescents.
A case of salivary duct carcinoma possibly arising from pleomorphic adenoma
Authors: Ariwansa Dedy , Paudel Durga , Morikawa Tetsuro , Yoshida Koki , Khurelchuluun Ariuntsetseg , Takahashi Shuhei , Sato Jun , Nakayama Eiji , Nagayasu Hiroki , Akbiko Yoshihiro 
Published: October 2022

Objective: We report a rare case of salivary duct carcinoma possibly arising from the malignant component of carcinoma ex pleomorphic adenoma.
Methods: A 56-year-old Japanese male complained of swelling in the left side of jaw for 2 years which was painless until 2 days ago. On extraoral examination, the face was bilaterally asymmetrical. An ultrasonography revealed hypoechoic mass of size 1.5x2.5x2.5 cm on left parotid gland. Computed tomography (CT) revealed a slight irregular mass on left parotid gland with no infiltration to adjacent tissues. Based on these findings, a clinical diagnosis of left parotid benign tumor was made.
Results: A surgical excision was performed under general anesthesia. On histopathological examination, the connective tissue was rich in fibrous components and was accompanied by hyaline. Epithelial cells with high atypia proliferating invasively as cords into connective tissue were observed. The intraductal component had Roman-bridge-like architecture with central portion undergoing comedonecrosis. Based on these findings, a final diagnosis of salivary duct carcinoma possibly arising from pleomorphic adenoma was made. p16 hypermethylation is a known phenomenon in oral malignancy. We also checked the methylation status of p16 gene and found high level of methylation in this tumor.
Conclusion: We reported a rare case of salivary duct carcinoma possibly arising from pleomorphic adenoma and also demonstrated high methylation level of p16 gene in the tumor.
Dentin microhardness and porosity of wistar rats teeth following herbal-based devitalizing agent application
Authors: Tanumiharja Maria , Mustakim Mustakim , Trilaksana Aries C. , Muslimin Lukman 
Published: October 2022

Objective: To evaluate the microhardness and porosity of the dentin of Wistar rats after pulp-out application.
Materials and Methods: This was laboratory experimental research with posttest design with control group. Twelve teeth of wistar rats were allocated into 2 groups, the test group and the control group. In the test group, teeth were prepared on the labial surface until half thickness of the dentin, then pulpout was applied to the base of cavity, covered with GIC. On the 7th day, euthanasia and extraction were performed to test the dentin microhardness with Vickers Hardness Tester and dentin porosity with Laser Scanning Microscope (LSM).
Results: The mean value of tooth hardness after pulp-out application was 22.23 ± 3.51 HV while the mean value of the control group was 27.70 ± 1.70 HV, with p value = 0.31 at 95% significance level. There was a decrease in tooth hardness of treated sample which was not significantly different compared to the control group. CLSM photo shows white lines on the sample surface as the exposed dentinal tubules with a higher intensity compared to the control group.
Conclusion: Pulp-out decreased tooth microhardness and cause porosity of the teeth.
К выступлению на встрече выпускников ВКШ при ЦК ВЛКСМ (1971-1990 гг.) и Института молодежи, созданного на базе ВКШ в 1990 году, с руководителями, преподавателями, сотрудниками и студентами Московского гуманитарного университета 23.07.2022
Authors: Ильинский Игорь Михайлович 
Published: October 2022

<p>Текст представляет собой выступление ректора Московского гуманитарного университета профессора И. М. Ильинского на собрании выпускников Высшей комсомольской школы при ЦК ВЛКСМ (ВКШ), а также преподавателей, сотрудников и студентов Московского гуманитарного университета — правопреемника ВКШ. Как отметил в своей речи И. М. Ильинский, данное собрание, ввиду событий на Украине, носит не ностальгический, а общественно-политический характер, так как внутренняя политика страны в любой, даже мирной ситуации, является продолжением его политики внешней; cегодня миллионы людей в России сохранили запас духовно-нравственных ценностей, уважения к собственной истории, что позволит укрепить суверенитет России и выполнить ее миссию на пути великого служения делу справедливости. </p>
Упоминания древних князей и образ прошлого в тезаурусе древнерусского эпоса
Authors: Алексеев Сергей Викторович 
Published: October 2022

<p>Статья посвящена реконструкции представлений создателей древнерусского «дружинного» эпоса о прошлом Руси на основе учета и семантического анализа упоминаний князей, древних по отношению ко времени написания. Для «Слова о полку Игореве» в наибольшей степени характерно внимание к дохристианскому прошлому, память о котором, однако, расходится с летописной и не связана с историческими князьями. В истории XI в. автора «Слова о полку Игореве» наиболее занимает период распада государства, который прямо ведет в его представлении к катастрофе Игорева похода. Автор «Слова о погибели Русской земли» продлевает эпоху единства во времена Владимира Мономаха и воплощает это единство в нем, поскольку Владимир Мономах является предком владимирских князей. Так и в этом памятнике, уже после монгольского нашествия, сочетается стремление к единству и подчеркивание величия своей княжеской династии. Этого сочетания совершенно чужда «Задонщина». Здесь не фигурируют предки непосредственно московских или владимирских князей, а образ прошлого сводится к древнейшим киевским князьям. Среди них центральное место занимает Владимир Святой, к которому автор непосредственно возводит своих героев — Дмитрия Донского и Владимира Храброго. Историческая память в «Задонщине» уже в большей степени книжная, чем устная, и дохристианское прошлое осмысляется исключительно через библейские образы.</p>
Практики медиапотребления российской молодежи в цифровом обществе (по результатам эмпирического исследования)
Authors: Полуэхтова Ирина Анатольевна 
Published: October 2022

<p>В статье представлены результаты социологического исследования медиапотребления, проведенного под руководством автора в октябре 2021 г. На основе эмпирических данных анализируются современные практики и динамика медиапотребления российской молодежи с фокусом на видеопотребление как доминирующее средство коммуникации в цифровом обществе; представлены актуальные количественные показатели охватов и временных затрат на потребление различных типов видео населением Российской Федерации. Показано наличие и воспроизводство цифрового разрыва в использовании медиа между возрастными группами. Установлено, что практики видеопотребления молодых более современны и разнообразны с точки зрения типов контента, используемых технологий, сервисов, способов просмотра, экранов. Выделены следующие особенности медиапрактик молодых россиян: преобладание цифровых (новых) медиа над традиционными; преобладание видео в медиапотреблении с предпочтением нелинейных (по запросу) форм просмотра; повышенный интерес к пользовательскому видео и предпочтение коротких форм видео, наиболее проявленный в самой молодой возрастной когорте (15–24 года); наличие универсального устройства (смартфон) и «любимого» интернет-ресурса (YouTube) для просмотра видео. </p>
Appendicular mass with pseudomyxoma peritonei: a case report
Authors: Kang Brahampreet S. , Arora Anshika , Harsh Meena 
Published: October 2022

Pseudomyxoma peritonei is an infrequently occurring clinical entity having an annual incidence of less than two per million. It is originated from the rupture of a tumour filled with mucinous substance. The intra-abdominal viscera are usually covered with a jelly-like substance. This syndrome originates most frequently from tumours of the appendix or ovaries. Genetic history is expected to play a role in the appendicular mucocele. The disease advances due to the presence of microbial agents expressed in carcinomas associated with gelatinous ascites. It typically has an insidious onset with a non-exclusive presentation like an increase in abdominal girth and associated abdominal pain with locoregional dissemination initially and dissemination to multiple sites later. The main sign is pelvic ascites. Diagnosis is made by combining radiological imaging with histopathology. Ultrasound aids in identifying the pelvic mass, peritoneal implants, calcifications, effusion, septa, the associated tumours (e.g., ovaries), the involvement of mesentery, and finalizing the surgical strategy. Usually, this condition is adequately treated by combining surgical excision and/or hyperthermic intra-peritoneal chemotherapy (HIPEC), which may be omitted by selecting the patient carefully.
Cost effectiveness analysis of typhoid fever vaccination in an endemic district of Kabale, Uganda
Authors: Odulusi Daniel 
Published: October 2022

Background: Typhoid fever is a preventable disease that affects the livelihood security of households and communities, accounting for a significant portion of the disease burden in Kabale district. Various preventive programs to control this burden such as curative services and vaccination are being implemented without empirical evidence of the effectiveness of either program in terms of costs and outcomes.Methodology: The study design is a mixed methods design in which for specific research objectives a cross-sectional survey was carried out in addition to a retrospective costing analysis. The outcome being a cost effectiveness evaluation of vaccination against typhoid with the comparator being no vaccination, expressed as the incremental cost effectiveness ratio. Results: Incidence rate of 39.8 per 1000, a case fatality rate of 0.061, and cost of illness of $75.62 for inpatient care and $33.85 for an outpatient case, with an average cost of illness of typhoid fever in Kabale district to be $54.74. In addition, typhoid fever costs Kabale district $217,158.8, of which $119,814.92 could be saved if a typhoid fever vaccination program is carried out, that will avert 2,189 cases of typhoid every year for three years. Vaccination results in 28,428.32 DALYs avoided. The resulting ICER of -6.348 reveals that the vaccination program against typhoid fever is both extremely cheaper and very effective in averting both typhoid cases and costs.Conclusions: a one-time fixed-post typhoid vaccination campaign in Kabale District, Uganda, was estimated to be a very highly cost-effective intervention from the public sector health care delivery perspective.
Perception and awareness of first year MBBS students about the subject community medicine
Authors: Gupta Sunanda , Kishore Jugal 
Published: October 2022

Background: In India, departments of the medical discipline community medicine or preventive and social medicine began to be established in the year 1955. It plays important role in medical curriculum for imparting training as comprehensive healthcare giver at various levels of health system. This study aimed at assessing perception and awareness of first year MBBS students about the subject community medicine, before formal introduction of the discipline as a part of their medical curriculum.Methods: The cross-sectional study was conducted in a class of seventy-four students of first year MBBS, at Vardhman Mahavir Medical College and Safdarjung Hospital, Delhi, in May 2022.Results: One-third of students had either parent/sibling/close relative as doctor. One-third of students knew at least one person who had pursued the discipline ‘community medicine’. Most of the students (85%) expected to learn healthcare management at primary healthcare level from the medical discipline. Only one-third of the students were aware of the subject before joining MBBS. Students whose parent/sibling/close relative is doctor, differed significantly about having the knowledge about the discipline before admission to MBBS (p value <0.001). Also, students who knew any person who had pursued community medicine as specialization, had significantly more chance of knowing about the subject before admission to MBBS.Conclusions: The medical discipline of community medicine is yet to gain familiarity among students. Community medicine specialists should come forward to address the issue and popularize the discipline as a component of medical curriculum and highlight their role in front of general population as well.
Analysis of Differentially Expressed MicroRNAs in OVA-induced Airway Remodeling Mice Model
Authors: Xu Chang , Song Yilan , Wang Chongyang , Jiang Jingzhi , Wang Zhiguang , Li Liangchang , Yan Guanghai 
Published: October 2022

MicroRNAs (miRNAs) can participate in airway remodeling by regulating immune molecule expression. Here, we aimed to identify the differential miRNAs involved in airway remodeling.
Airway remodeling was induced by ovalbumin in female BALB/C mice. The differentially expressed miRNAs were screened with microarray. GO (Gene Ontology) and KEGG enrichment analysis was performed. The miRNA target gene network and miRNA target pathway network were constructed. Verification with real-time PCR and Western blot was performed.
We identified 63 differentially expressed miRNAs (50 up-regulated and 13 down-regulated) in the lungs of ovalbumin-induced airway remodeling mice. Real-time PCR confirmed that 3 miRNAs (mmu-miR-1931, mmu-miR-712-5p, and mmu-miR-770-5p) were significantly up-regulated, and 4 miRNAs (mmu-miR-128-3p, mmu-miR-182-5p, mmu-miR-130b-3p, and mmu-miR-20b-5p) were significantly down-regulated. The miRNA target gene network analysis identified key mRNAs in the airway remodeling, such as Tnrc6b (trinucleotide repeat containing adaptor 6B), Sesn3 (sestrin 3), Baz2a(bromodomain adjacent to zinc finger domain 2a), and Cux1 (cut like homeobox 1). The miRNA target pathway network showed that the signal pathways such as MAPK (mitogen-activated protein kinase), PI3K/Akt (phosphoinositide 3-Kinase/protein kinase B), p53 (protein 53), and mTOR (mammalian target of rapamycin) were closely related to airway remodeling in asthma.
Collectively, differential miRNAs involved in airway remodeling (such as mmu-miR-1931, mmu-miR-712-5p, mmu-miR-770-5p, mmu-miR-128-3p mmu-miR-182-5p, and mmu-miR-130b-3p) as well as their target genes (such as Tnrc6b, Sesn3, Baz2a, and Cux1) and pathways (such as MAPK, PI3K/Akt, p53, mTOR pathways) have been identified. Our findings may help to further understand the pathogenesis of airway remodeling.
Molecular Characteristics of Bladder Tumor: Increased Gene Expression of MAGE-A6 and MAGE-A11 with Decreased MicroRNA-34a and MicroRNA-125b
Authors: Aghamajidi Azin , Ousati Ashtiani Zahra , Mohsenzadegan Monireh , Tajik Nader , Ghafoori Yazdi Mahmood , Sharifi Laleh , Nowroozi Mohammad Reza 
Published: October 2022

Bladder cancer is recognized as one of the top ten most common cancers worldwide. Activation of oncogenes, inactivation of tumor suppressor genes, and dysregulation of androgen signaling pathways are three major pathophysiological causes in the development of bladder tumors. Discovering potential biomarkers is required for the management and immunotherapy of bladder cancer. Melanoma-associated antigen (MAGE)-A6 and MAGE-A11 are two cancer-testis antigens that are potential coregulators of androgen receptors. MicroRNAs, especially miR-34a and miR-125b are two important tumor suppressors that play a critical role in regulating different signaling pathways and inhibiting tumor development.
Twenty-nine surgical tissue biopsies were collected from patients with no preoperative chemotherapy or radiotherapy (26 males and, 3 females, mean age±SD: 62.4±13.3 years). Seventeen adjacent uninvolved tissues with no abnormalities upon histological examination were considered normal controls (14 males and, 3 females, mean age±SD: 64.2±7.4 years) . Quantitative PCR was performed to evaluate the gene expression level of MAGE-A6, MAGE-A11, miR-34a, and miR-125b in bladder cancer biopsies.
MAGE-A6 and MAGE-A11 expressions were significantly increased in bladder tumors compared with normal tissues. However, the expression levels of miR-34a and miR-125b were significantly downregulated in bladder tumor tissues. Interestingly, the expression level of all these genes was significantly associated with tumor grade, pathological stage (pT), and muscular invasion.
MAGE-A6 and MAGE-A11 can be considered potential markers for the diagnosis and immunotherapy of bladder tumors. Furthermore, the modulation of miR-34a and miR-125b gene expression in association with increased MAGE-A6 and MAGE-A11 genes could open a new horizon in the improvement of bladder cancer.
The T Cell Receptor Repertoire Diversity Following Hematopoietic Stem Cell Transplantation
Authors: Zamani Fahimeh , Mirfakhraie Reza , Safaee Nodehi Sayyed Reza , Mollaei-Kandelous Yaghoub , Jafari Hossein , Farahmand Mohammad , Rezaei Farhad , Teymoori-Rad Majid , Movafagh Abolfazl 
Published: October 2022

Immune reconstitution after hematopoietic stem cell transplantation (HSCT) with a conditioning regimen has appeared to be a promising treatment for autoimmune diseases and hematologic malignancies. This study aimed to assess the T cell receptor (TCR) repertoire diversity in CD4+ cells of patients with hematological malignancies who received allogeneic or autologous HSCT.
The diversity of the TCR repertoire was evaluated in 13 patients with hematologic malignancies before and four months after HSCT. Amino acid changes in the 25 Vβ families were evaluated using Spectratyping and data were presented as Hamming distance (HD). HD more than 20% was considered a change in TCR repertoire after HSCT.
The mean HD was significantly changed after transplantation in all Vβ gene families, with most amino acid changes in p4 and p22 families. There was a strong negative correlation between the HD as the index of TCR repertoire and age (r=−0.62,). The results revealed no association between HD mean and parameters such as sex, disease, conditioning regimen, and type of transplantation.
Our data revealed that commonly used conditioning regimens in Iran could successfully cause TCR repertoire diversity in patients with hematologic malignancies in the short term. The amount of change in TCR repertoire was inversely correlated with the increasing age of patients.