bluuebunny/crossref_metadata_2025_split huggingface dataset:
Systemic Inflammation Response Index Is a Promising Prognostic Marker in Elderly Patients With Heart Failure: A Retrospective Cohort Study
Authors: Wang Xue , Ni Qingwei , Wang Jie , Wu Shujie , Chen Peng , Xing Dawei 
Published: July 2022

BackgroundHeart failure (HF) is a clinical syndrome caused by ventricular dysfunction, which leads to the decline of activity tolerance and repeated hospitalization, which seriously affects the quality of life and is the main cause of death of the elderly. It has long been observed that the pathophysiological mechanism of HF is associated with systemic inflammation. This study aims to explore the association between the systemic inflammation response index (SIRI), a novel biomarker of inflammation, and outcomes in elderly patients with HF.MethodsData was extracted from the Medical Information Mart data for Intensive Care III (MIMIC-III) database and the Second Affiliated Hospital of Wenzhou Medical University. The primary outcome was 90-day all-cause mortality. The secondary outcomes included 1-year all-cause mortality, the length of hospital or intensive care unit (ICU) stay, and the need for renal replacement therapy (RRT). Cox proportional hazards regression, linear regression, and logistic regression models were used to assess the association between SIRI levels and all-cause mortality, the length of hospital or ICU stay, the need for RRT, respectively. Moreover, Pearson correlation analysis was conducted to evaluate the correlation between SIRI and C-reactive protein (CRP).ResultsThis study cohort included 3,964 patients from the MIMIC-III database and 261 patients from the Second Affiliated Hospital of Wenzhou Medical University. The result suggested that SIRI was independently associated with the 90-day, and 1-year all-cause mortality in elderly patients with HF (tertile 3 vs. tertile 1: adjusted HR, 95% CI: 1.41 (1.18, 1.68), 1.19 (1.03, 1.37); p trend = 0.0013, 0.0260; respectively). Elevated SIRI was associated with increased the length of hospital or ICU stay after adjusting for multiple confounders (tertile 3 vs. tertile 1: β, 95% CI: 0.85 (0.16, 1.54); 0.62 (0.18, 1.06); p trend = 0.0095, 0.0046; respectively). Furthermore, we found that patients with higher SIRI levels were more likely to require RRT (tertile 3 vs. tertile 1: OR, 95% CI: 1.55 (1.06, 2.28); p trend = 0.0459). Moreover, we confirmed that SIRI was statistically positively correlated with CRP (correlation coefficient r = 0.343, p &lt;0.001).ConclusionsSIRI could be a novel promising inflammatory biomarker for predicting all-cause mortality in elderly patients with HF. And the patients with higher SIRI values had the longer length of hospital or ICU stay and were more likely to require for RRT. Of note, this study also verified a statistically significant positive correlation between SIRI and the inflammatory marker CRP, highlighting the importance of systemic inflammation as a determinant of outcome in patients with HF.
Hub Genes Identification, Small Molecule Compounds Prediction for Atrial Fibrillation and Diagnostic Model Construction Based on XGBoost Algorithm
Authors: Yang Lingzhi , Chen Yunwei , Huang Wei 
Published: July 2022

BackgroundAtrial fibrillation (AF) is the most common sustained cardiac arrhythmia and engenders significant global health care burden. The underlying mechanisms of AF is remained to be revealed and current treatment options for AF have limitations. Besides, a detection system can help identify those at risk of developing AF and will enable personalized management.Materials and MethodsIn this study, we utilized the robust rank aggregation method to integrate six AF microarray datasets from the Gene Expression Omnibus database, and identified a set of differentially expressed genes between patients with AF and controls. Potential compounds were identified by mining the Connectivity Map database. Functional modules and closely-interacted clusters were identified using weighted gene co-expression network analysis and protein–protein interaction network, respectively. The overlapped hub genes were further filtered. Subsequent analyses were performed to analyze the function, biological features, and regulatory networks. Moreover, a reliable Machine Learning-based diagnostic model was constructed and visualized to clarify the diagnostic features of these genes.ResultsA total of 156 upregulated and 34 downregulated genes were identified, some of which had not been previously investigated. We showed that mitogen-activated protein kinase and epidermal growth factor receptor inhibitors were likely to mitigate AF based on Connectivity Map analysis. Four genes, including CXCL12, LTBP1, LOXL1, and IGFBP3, were identified as hub genes. CXCL12 was shown to play an important role in regulation of local inflammatory response and immune cell infiltration. Regulation of CXCL12 expression in AF was analyzed by constructing a transcription factor-miRNA-mRNA network. The Machine Learning-based diagnostic model generated in this study showed good efficacy and reliability.ConclusionKey genes involving in the pathogenesis of AF and potential therapeutic compounds for AF were identified. The biological features of CXCL12 in AF were investigated using integrative bioinformatics tools. The results suggested that CXCL12 might be a biomarker that could be used for distinguishing subsets of AF, and indicated that CXCL12 might be an important intermediate in the development of AF. A reliable Machine Learning-based diagnostic model was constructed. Our work improved understanding of the mechanisms of AF predisposition and progression, and identified potential therapeutic avenues for treatment of AF.
Left atrial epicardial adipose tissue is associated with low voltage zones in the left atrium in patients with non-valvular atrial fibrillation
Authors: Shao Yameng , Chen Lei , Chen Wensu , Sang Chuanyi , Xu Changjiang , Zhang Chaoqun 
Published: July 2022

ObjectiveEpicardial adipose tissue (EAT) is related to atrial fibrillation (AF), but the specific mechanism is still unclear. Left atrial (LA) low voltage zones (LVZ) can well reflect atrial fibrosis. This study investigated the relationship between EAT and LVZ in non-valvular AF (NVAF) patients.MethodsThis observational study including patients with NVAF (n = 214) undergoing radiofrequency ablation (RFCA) for the first time in our hospital and 62 matched controls. The EAT volume and attenuation were measured by contrast-enhanced computed tomography. A three-dimensional mapping system was used to map the left atrial endocardium and evaluate LA-LVZ. Patients were divided into LVZ and non-LVZ groups according to the presence or absence of LVZ.ResultsPatients with AF showed higher LA-EAT volume and lower attenuation value than controls (29.7 ± 11.2 cm3 vs. 20.9 ± 8.6 cm3, P = 0.021; −91.2 ± 5.6 HU vs. −88.7 ± 5.9 HU, P &lt; 0.001). Compared with the group without LVZ, there were significant differences in age [65 (59–71) vs. 60 (52–69), P = 0.006], LAVI [75.1 ± 20.7 ml/m2 vs. 67.2 ± 20.9 ml/m2, P = 0.018], LA-EAT volume (34.8 ± 11.5 cm3 vs. 28.1 ± 10.6 cm3, P &lt; 0.001) and LA-EAT attenuation (−93.9 ± 5.3 HU vs. −90.4 ± 5.5 HU, P &lt; 0.001). Multivariate regression analysis showed that age (OR = 1.040; 95%CI: 1.001–1.078, P = 0.042), LAVI (OR = 1.019; 95%CI: 1.002–1.037, P = 0.032), LA-EAT volume (OR = 1.193; 95%CI: 1.015–1.402, P = 0.034) and attenuation value (OR = 0.801; 95%CI: 0.701–0.916 P = 0.001) were independent predictors of LVZ. After LA-EAT attenuation was incorporated into the clinical model, the comprehensive discrimination and net reclassification tended to improve (IDI and NRI &gt; 0, P &lt; 0.05).ConclusionLA-EAT volume and attenuation values can independently predict the presence of LVZ, and LA-EAT attenuation has a better predictive value than LA-EAT volume.
Endovascular surgery for thoracic aortic pathologies involving the aortic arch
Authors: Lu Heng , Huang Ling-chen , Chen Liang-wan 
Published: July 2022

BackgroundAortic arch pathologies are serious clinical conditions associated with a very dismal prognosis. Traditional open surgery has a high mortality and is not suitable for critically ill patients. Recently years, endovascular treatment of thoracic aorta has made rapid progress and has been gradually applied to the treatment of aortic arch pathologies. However, maintaining cerebral blood flow during endovascular treatment of aortic arch lesions remains a challenge at this time. This study aims to evaluate the feasibility, efficacy, and safety of endovascular treatment of thoracic aortic pathologies involving the aortic arch, and to present initial experience with this technique.MethodsFrom October 2016 to December 2020, patients who met the inclusion criteria were enrolled. All patients underwent thoracic endovascular aortic repair with the proximal landing zone of the stent-graft in the aortic arch at Ishimaru zones 0–1, in which cerebral flow needs to be maintained during surgery, and the supra-aortic branches were reconstruction with eitherin situfenestration or the chimney technique.ResultsA total of 62 cases with lesions involving the arch were treated with endovascular surgery. Total supra-aortic branches reconstruction was successfully performed in 51 cases, the left carotid artery (LCA) and the innominate artery reconstruction were performed in eight cases, the left subclavian artery (LSA) and the LCA were reconstructed in three patients. Among them, thein situfenestration or chimney repair technique for the LSA was successful performed in 42 and 12 cases. However, in 20 patients, attempts to reconstruction the LSA using the fenestration technique were unsuccessful due to tortuous and angulated vessels. Early mortality was 6.45%. No neurological complications related to surgery occurred. Computer tomography images at post-operative follow-up (mean 3.51 months) confirmed patency of all branch stents without any signs of endoleaks, migration, conversion to retrograde dissection or receive open-heart surgery.ConclusionThe endovascular technique is an effective, feasible, safe and repeatable method to reconstruct the aortic arch, which allows for the reconstruction of the supra-aortic branches.
Benefits of Interventional Telemonitoring on Survival and Unplanned Hospitalization in Patients With Chronic Heart Failure
Authors: Galinier Michel , Itier Romain , Matta Anthony , Massot Montse , Fournier Pauline , Galtier Ghislaine , Ayot Sandrine , Nader Vanessa , Rene Max , Lecourt Laurent , Roncalli Jerome 
Published: July 2022

AimsTo assess the effect of interventional specialized telemonitoring (ITM) compared to standard telemonitoring (STM) and standard of care (SC) on preventing all causes of death, cardiovascular mortality and unplanned hospitalization in heart failure (HF) patients.MethodsWe compared outcomes in three groups of HF patients followed by different modalities: SC, STM and ITM. The telemonitoring was performed by the specialized HF-cardiology staff at Toulouse University Hospital. All patients were followed with the same manner including daily weight monitoring using on-line scales, self-monitoring and reporting symptoms via a device. The difference between groups was in the management of the received alerts. In STM-group, patients were contacted by a member of telemedical center and the main responsibility for patient's therapy was taken by their primary care physicians while in the ITM-group, a cardiologist intervenes immediately in case of alerts for diuretic dose adjustment or escalation therapy or programmed hospitalization if necessary. Outcomes were compared between the three study groups and Kaplan-Meier analysis was performed.ResultsFour hundred fourteen HF-patients derived from two French cohorts (OSICAT and ETAPES) were included in this study and subsequently enrolled in the following three groups: ITM-group (n = 220), STM-group (n = 99), and SC-group (n = 95). During the mean follow-up period of 341 days, there were significantly fewer primary endpoints like unplanned hospitalization (13.6 vs. 34.3 vs. 36.8%, p &lt; 0.05), all-causes of death (4.5 vs. 20.2 vs. 16.8%, p &lt; 0.05) and cardiovascular mortality (3.2 vs. 15.2 vs. 8.4%, p &lt; 0.05) in the ITM-group. The multivariable logistic regression revealed a significant negative association between the ITM and unplanned hospitalization [OR = 0.303 95% CI (0.165–0.555), p &lt; 0.001) and all-causes of death [OR = 0.255 95% CI (0.103–0.628), p = 0.003], respectively. Kaplan Meier and log rank test showed significant difference in median event-free survival in favor of ITM-group.ConclusionsIn the ITM follow-up HF group, delivered by a cardiology team, the rate of unplanned hospitalization and all-causes of death are lower than SC or STM.
Research of Light Use Efficiency for Paddy Rice Using Multi-Angle Hyperspectral Observations
Authors: Guo Jianmao , Zhang Zhanhao , Guo Caiyun , Jin Shuyuan 
Published: July 2022

Light use efficiency (LUE) is a critical variable for modeling gross primary production (GPP) of vegetation. The photochemical reflectance index (PRI) is based on reflectance at 531 and 570 nm, which has great potential in predicting the light use efficiency (LUE) and makes LUE related to plant optical characteristics. Despite the great achievement in understanding the correlation of PRI and LUE on forests, the application of PRI in estimating LUE on crops has almost been ignored. The present study reported the ability of multi-angle PRI to track eddy covariance (EC)-based LUE in a rice field in East China. We found that PRI can estimate LUE in sunny days (R2 = 0.4; p &lt; 0.05). The correlation of PRI and LUE was greater than that at OZA of 0° (R2 = 0.4; p &lt; 0.05) after distinguishing different OZAs and scatter directions and was the greatest in the backscatter direction with an OZA of 60° (R2 = 0.7; p &lt; 0.01). This correlation was also corrected by the bidirectional reflectance distribution function (BRDF), where R2 = 0.72 after correction. We noted that the relationship between PRI and LUE on cloudy days was poor, where R2 = 0.26. Photosynthetically active radiation (PAR) had an influence on the LUE and PRI, while vapor pressure deficit (VPD) and air temperature (Ta) had negative influences on the correlation of PRI and LUE. Our research suggests that PRI can efficiently track the LUE of the rice growth period when considering environmental factors and rice canopy structures.
Research on Application of the Bolt-Truss Coupling Support Technology in Roadway With Water-Rich and Soft Rock
Authors: Zhang Jianguo , Wang Yingwei , Qi Xiaohan , Zhu Tongguang 
Published: July 2022

In the process of underground energy mining, the stability of roadway support is an important guarantee. In order to study the application of the anchor cable-truss support technology in water-rich soft rock roadways, the mechanical analysis of the anchor cable-truss structure is carried out, and the surrounding rock deformation of different supporting methods is numerically simulated under the consideration of the fluid–solid coupled interaction. We observed that the anchor cable (rod)-double arch truss coupling support can control the deformation of the surrounding rock and the expansion of the plastic zone well. The maximum vault subsidence of the roadway is 0.017 m, the horizontal convergence is 0.054 m, and the deformation of floor heave is 0.02 m, which are 3.8, 16.3, and 4% of the deformation under unsupported conditions, respectively; the roadway deformation is effectively controlled. The research results have certain guiding significance for the support design of the water-rich broken soft rock roadway.
Spatiotemporal Variation of Late Quaternary River Incision Along the Heihe River in the Northeastern Tibetan Plateau, Constrained by Dating Fluvial Terraces
Authors: Cao Xilin , Hu Xiaofei , Pan Baotian , Zhao Zhijun 
Published: July 2022

Rates of river incision are widely used to track changes in rock uplift rate and climate over time and space. However, the relationship between the spatiotemporal variation of river incision and past tectonic or climatic processes is still unclear. Here, we focus on the spatial patterns of river incision in the interior and front of the Qilian Shan in the northeastern Tibetan Plateau. A sequence of late Quaternary terraces is well preserved along the Heihe River across the central Qilian Shan. We complement existing chronologic data with five new optically stimulated luminescence ages and one cosmogenic radionuclide 10Be exposure age of terrace abandonment. At the mountain front, the river incision rate was ∼1 mm/yr over the past 100 kyr, while the range was from 2 to 7 mm/yr during the Holocene. We attribute the fast incision rates during the Holocene to the progressive decrease of the river gradient induced by the warm and wet Holocene climate. In the interior of the mountains (the Qilian basin site), the river incision rates were close to 1 mm/yr since ∼53 ka, suggesting that the upstream incision rate remained stable from the late Pleistocene to the Holocene. This observation further suggests that the adjustment of the climate-induced longitudinal river profile is limited to the downstream reach, especially along the front of the mountain range. We conclude that the long-term incision rate (during the late Pleistocene) is explained by ongoing uplift driven by fault activity, which determines the background rate of fluvial incision (∼1 mm/yr). On the other hand, denudation rates on the millennial timescale estimated by previous studies in this region are &lt; 1 mm/yr, suggesting that landscape-scale erosion lags behind trunk river incision.
Source Model for the 2022 Qinghai Menyuan Ms 6.9 Earthquake Based on D-InSAR
Authors: Liao Jiangtao , Liang Chuntao , Wang Chaoliang , Cao Feihuang , Ye Chengming , Yang Yinghui 
Published: July 2022

On 8 January 2022, an Ms 6.9 earthquake occurred in Menyuan County, Qinghai Province, China. This earthquake ruptured a patch of the Qilian-Haiyuan fault in the northeast margin of the Qinghai-Tibet Plateau. In order to understand the seismogenic structure of this earthquake and analyze the fault activity, we use differential synthetic aperture radar interferometry (D-InSAR) technology to obtain a complete co-seismic displacement field on the surface, and use pixel tracking algorithm to extract the trace of the ruptured fault. The slip distribution of the seismogenic fault was inverted using the steepest descent method, and the Coulomb stress change caused by the earthquake was also calculated. Surface deformation results show that the Menyuan earthquake produced obvious surface displacements in an area of 50 × 40 km2. The displacements are mainly distributed in the western segment of the Lenglongling fault and the eastern segment of the Tolaishan fault. The maximum displacements in the ascending and descending orbits in the LOS direction are 59.7 and 94.7 cm, respectively. The co-seismic slip results show that the strike, dip and average slip angles of the seismogenic fault are 108°, 79° dipping to SW, and 4°, respectively. On the whole, the fault is mainly of left-lateral, with a small amount of thrust component and only one co-seismic rupture center in our inversion result. The rupture center is located at a depth of ∼5 km below the surface, and the maximum slip is 3.1 m. The total seismic moment released by this earthquake is 1.28 × 1019 N·m, and the corresponding moment magnitude is 6.67. Finally, the static Coulomb stress change results show that parts of the Lenglongling fault, the Tolaishan fault, the Sunan-Qilian fault and the Minyue-Damaging fault are loaded, emphasizing the importance for earthquake risk assessment of these fault.
Chinese Visceral Adiposity Index Is Associated With Incident Renal Damage in Patients With Hypertension and Abnormal Glucose Metabolism: A Longitudinal Study
Authors: Lin Mengyue , Li Nanfang , Heizhati Mulalibieke , Gan Lin , Zhu Qing , Yao Ling , Li Mei , Yang Wenbo 
Published: July 2022

ObjectiveTo evaluate the association between Chinese visceral adiposity index (CVAI) and incident renal damage and compared its predictive power with that of other visceral obesity indices in patients with hypertension and abnormal glucose metabolism (AGM).MethodsThis retrospective cohort consecutively included patients with hypertension and AGM who did not have renal damage at baseline. Renal damage was defined using the estimated glomerular filtration rate (eGFR) and urine protein. Multivariable Cox regression analysis was used to evaluate the association between CVAI and incident renal damage. Restricted cubic splines were used to determine the shape of the association. The predictive power of the CVAI was examined and directly compared with other indices, including the VAI, body mass index (BMI), waist circumference (WC), and waist-to-height ratio (WHtR), using the area under the receiver operating characteristic curve (AUC) and C-index.ResultsIn total, 2,033 patients with hypertension and AGM were included. During a median follow-up of 2.6 years, the incidence of renal damage was 31.5, 48.9, 56.8, and 67.5/1,000 person-years across the quartiles of CVAI. Compared with the first quartile, the risk of renal damage was higher in the second (hazard ratio (HR) = 1.36 [95% CI: 0.93−1.97]), third (HR = 1.57 [95% CI: 1.09−2.27]), and fourth (HR = 1.65 [95% CI: 1.11−2.44]) quartiles (p for trend = 0.011). A linear dose–response association was observed. Sensitivity and subgroup analyses confirmed the robustness and consistency of the results. In terms of predictive power, the CVAI had the highest AUC and C-index values.ConclusionsCVAI is positively associated with renal damage risk in a linear dose–response pattern and has the best performance in predicting incident renal damage in patients with hypertension and AGM. The CVAI may serve as a reliable indicator for identifying patients at a high risk of renal damage.