bluuebunny/crossref_metadata_2025_split huggingface dataset:
Associated factors with poor treatment response to initial glucocorticoid therapy in patients with adult-onset Still’s disease
Authors: Kondo Fumiaki , Sugihara Takahiko , Umezawa Natsuka , Hasegawa Hisanori , Hosoya Tadashi , Kimura Naoki , Mori Masaaki , Yasuda Shinsuke 
Published: April 2022

Abstract
Background
High-dose glucocorticoids (GC) are first-line treatment for adult-onset Still’s disease (AOSD); however, some of the patients remain refractory to initial GC therapy, or rapidly relapse. The aim of this study was to identify prognostic factors for poor treatment response to initial GC therapy for AOSD.

Methods
Data on newly diagnosed AOSD patients were extracted from our database (n=71, mean age 51.6 years). The primary outcome was a poor treatment outcome at 4 weeks, which was defined as failure to achieve remission or relapse after achieving remission within 4 weeks, followed by administration of two or more rounds of GC pulse therapy or of any other immunosuppressive drugs.

Results
The initial mean dose ± standard deviation of prednisolone was 0.82 ± 0.23 mg/kg/day, and 34 (47.3%) patients received GC pulse therapy at week 0. Twenty-nine of 71 patients exhibited a poor treatment outcome at 4 weeks (40.8%). The second round of GC pulse therapy or immunosuppressive drugs was added in 17 or 24 of the 29 patients, respectively. These patients had higher baseline white blood cell (WBC) counts, serum ferritin levels, systemic feature score based on clinical symptoms (modified systemic feature score, mSFS), more hemophagocytic syndrome (HPS) over the 4 weeks, and the higher severity score based on modified Pouchot score or severity index of the Japanese Ministry of Health, Labour and Welfare, than the remaining 42 patients. Multivariable logistic regression model identified baseline WBC count as a prognostic factor for poor outcome (odds ratio per 1000/μl increment: 1.12, 95% CI 1.04–1.29), while thrombocytopenia, hyperferritinemia, and mSFS at baseline did not achieve statistical significance. Receiver-operating characteristic curve analysis showed that the optimal cut-off for WBC count was 13,050/μl. The Kaplan-Meier method showed the cumulative rate of poor treatment outcome to be 60.0% in patients with WBC ≥13,050/μl and 23.5% in those with WBC <13,050/μl.

Conclusions
A higher WBC count but not thrombocytopenia, hyperferritinemia, and mSFS at baseline was a significant prognostic factor for poor treatment outcome at week 4 in this retrospective cohort of AOSD patients. Our findings provide important information for determining the initial treatment strategy of newly-diagnosed AOSD.
Predictors of adherence to prescribed exercise programs for older adults with medical or surgical indications for exercise: a systematic review
Authors: Shaw Julia F. , Pilon Sophie , Vierula Matthieu , McIsaac Daniel I. 
Published: April 2022

Abstract
Background and objectives
Prescribed exercise to treat medical conditions and to prepare for surgery is a promising intervention to prevent adverse health outcomes for older adults; however, adherence to exercise programs may be low. Our objective was to identify and grade the quality of predictors of adherence to prescribed exercise in older adults.

Methods
Prospective observational and experimental studies were identified using a peer-reviewed search strategy applied to MEDLINE, EMBASE, Cochrane, and CINAHL from inception until October 6, 2020. Following an independent and duplicate review of titles, abstracts, and full texts, we included prospective studies with an average population age >65 years, where exercise was formally prescribed for a medical or surgical condition. We excluded studies where exercise was prescribed for a chronic musculoskeletal condition. Risk of bias was assessed using the Quality in Prognostic studies tool or Cochrane risk of bias tool, as appropriate. Predictors of adherence were identified and graded for quality using an adaptation of the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) framework for predictor studies.

Results
We included 19 observational studies and 4 randomized controlled trials (n=5785) Indications for exercise included cardiac (n=6), pulmonary rehabilitation (n=7), or other (n=10; surgical, medical, and neurologic). Of the 10 studies that reported adherence as the percent of prescribed sessions completed, average adherence was 80% (range 60–98%; standard deviation (SD) 11%). Of the 10 studies that reported adherence as a categorical threshold demarking adherent vs not adherent, average adherence was 57.5% (range 21–83%; SD 21%). Moderate-quality evidence suggested that positive predictors of adherence were self-efficacy and good self-rated mental health; negative predictors were depression (high quality) and distance from the exercise facility. Moderate-quality evidence suggested that comorbidity and age were not predictive of adherence.

Conclusions
These findings can inform the design of future exercise programs as well as the identification of individuals who may require extra support to benefit from prescribed exercise.

Systematic review registration
PROSPERO CRD42018108242
Orthostatic hypotonia as a probably late sequela of SARS-CoV-2 infection in a patient provided with palliative home care: a case report
Authors: Kluczna Agnieszka , Mularska Elżbieta , Dzierżanowski Tomasz 
Published: April 2022

Abstract
Background
The SARS-CoV-2 pandemic has become a challenge for the entire healthcare system. Treatment for COVID-19 includes casual and symptomatic management in the acute phase of the disease and focuses on the treating early complications of the disease. Long-term health consequences of the infection have not yet been fully identified. A special group of patients with comorbidities, including neoplastic disease for whom the interpretation and management of symptoms is a major challenge.

Case presentation
In this case report, we present a 73-year-old woman with recently diagnosed gastric adenocarcinoma in whom we diagnosed orthostatic hypotonia in the aftermath of SARS-CoV-2 infection. We administered thiethylperazine maleate 6.5 mg daily. Additionally, we advised the patient to slowly lift from the recumbent position, raise the headboard, take meals in small portions, and increase fluid intake. These pharmacological and nonpharmacological measures resulted in sustained relief of dizziness and nausea.

Conclusions
The occurrence of orthostatic hypotonia seems a possible late sequela of SARS-CoV-2 infection, and simple measures appeared sufficient to achieve sustained symptom control.
Re-discovering Aurelio Peccei’s contribution to Futures Studies
Authors: Facioni Carolina , Paura Roberto 
Published: April 2022

AbstractThis work aims to enhance the contribution of Aurelio Peccei to Futures Studies and its unaltered relevance in the light of the world’s current scientific issues. Peccei’s contribution in Futures Studies is often identified with his propulsive role in the birth of the Club of Rome (1968) and in the promotion of the report “The Limits to Growth” (1972). Although this would be enough to make him a central figure in the history of Futures Studies, his whole intellectual journey is worth emphasizing. This work focuses on the “epistemic impact” of Peccei in the field research on possible futures. Peccei not only argued the fundamental need to translate complexity into a forecasting model: as an ante litteram anticipator, he dedicated his life to seek a development model respecting both the human tendency towards constant evolution and biosphere. A theoretical impact that allowed many fundamental UN initiatives—from the 1987 Report of the World Commission on Environment and Development to the 2015 Report on Sustainable Development Goals (SDGs)—and also helped the development of a forward-looking social research.
Making peace with disliked others: the effects of a short loving-kindness meditation on implicit and explicit emotional evaluations
Authors: Schroter Franziska Anna , Jansen Petra 
Published: April 2022

Abstract
Background
The main goal of the study was to investigate the effects of a short loving-kindness meditation (LKM) on explicit and implicit evaluations of oneself and disliked public persons. We expected a more positive explicit and implicit evaluation of oneself and a disliked public person after the LKM and a mood improvement.

Methods
Before and after the implementation of a short LKM vs. imagery task, mood, explicit and implicit evaluations were analyzed in 69 students.

Results
Our results demonstrated only a reduction in negative and positive mood in both groups and regarding the explicit and implicit tasks, only a significant main effect of picture and a trend for the time*group interaction for mood, implicit and explicit attitudes with medium effect-sizes.

Conclusions
A possible influence of a short intervention on emotional evaluations should be treated with caution. The claim that a short loving-kindness meditation enhances social connectedness might awake false hopes. This study suggests being careful with the interpretation of single meditation effects and future studies should examine the effects of a long-lasting meditation training on explicit and implicit evaluations of the self and disliked politicians as well as the sustainability of those effects.
Recent advances in the chemo-biological characterization of decalin natural products and unraveling of the workings of Diels–Alderases
Authors: Watanabe Kenji , Sato Michio , Osada Hiroyuki 
Published: April 2022

AbstractThe Diels–Alder (DA) reaction refers to a [4 + 2] cycloaddition reaction that falls under the category of pericyclic reactions. It is a reaction that allows regio- and stereo-selective construction of two carbon–carbon bonds simultaneously in a concerted manner to generate a six-membered ring structure through a six-electron cyclic transition state. The DA reaction is one of the most widely applied reactions in organic synthesis, yet its role in biological systems has been debated intensely over the last four decades. A survey of secondary metabolites produced by microorganisms suggests strongly that many of the compounds possess features that are likely formed through DA reactions, and most of them are considered to be catalyzed by enzymes that are commonly referred to as Diels–Alderases (DAases). In recent years, especially over the past 10 years or so, we have seen an accumulation of a substantial body of work that substantiates the argument that DAases indeed exist and play a critical role in the biosynthesis of complex metabolites. This review will cover the DAases involved in the biosynthesis of decalin moieties, which are found in many of the medicinally important natural products, especially those produced by fungi. In particular, we will focus on a subset of secondary metabolites referred to as pyrrolidine-2-one-bearing decalin compounds and discuss the decalin ring stereochemistry and the biological activities of those compounds. We will also look into the genes and enzymes that drive the biosynthetic construction of those complex natural products, and highlight the recent progress made on the structural and mechanistic understanding of DAases, especially regarding how those enzymes exert stereochemical control over the [4 + 2] cycloaddition reactions they catalyze.
Snakebite victim profiles and treatment-seeking behaviors in two regions of Kenya: results from a health demographic surveillance system
Authors: Larson Peter S. , Ndemwa Morris , Thomas Aleksandra F. , Tamari Noriko , Diela Paul , Changoma Mwatasa , Mohamed Abdullatif , Larson Miles C. , Ketenci Kaan Cem , Goto Kensuke , Kaneko Satoshi 
Published: April 2022

Abstract
Introduction
Snakebites are a major cause of permanent injury and death among poor, rural populations in developing countries, including those in East Africa. This research characterizes snakebite incidence, risk factors, and subsequent health-seeking behaviors in two regions of Kenya using a mixed methods approach.

Methods
As a part of regular activities of a health demographic surveillance system, household-level survey on snakebite incidence was conducted in two areas of Kenya: Kwale along the Kenyan Coast and Mbita on Lake Victoria. If someone in the home was reported to have been bitten in the 5 years previous to the visit, a survey instrument was administered. The survey gathered contextual information on the bite, treatment-seeking behavior and clinical manifestations. To obtain deeper, contextual information, respondents were also asked to narrate the bite incident, subsequent behavior and outcomes.

Results
8775 and 9206 households were surveyed in Kwale and Mbita, respectively. Out of these, 453 (5.17%) and 92 (1.00%) households reported that at least one person had been bitten by a snake in the past 5 years. Deaths from snakebites were rare (4.04%), but patterns of treatment seeking varied. Treatment at formal care facilities were sought for 50.8% and at traditional healers for 53.3%. 18.4% sought treatment from both sources. Victims who delayed receiving treatment from a formal facility were more likely to have consulted a traditional healer (OR 8.8995% CI [3.83, 20.64]). Delays in treatment seeking were associated with significantly increased odds of having a severe outcome, including death, paralysis or loss of consciousness (OR 3.47 95% CI [1.56; 7.70]).

Conclusion
Snakebite incidence and outcomes vary by region in Kenya, and treatment-seeking behaviors are complex. Work needs to be done to better characterize the spatial distribution of snakebite incidence in Kenya and efforts need to be made to ensure that victims have sufficient access to effective treatments to prevent death and serious injury.
Deterioration of Glycemic Control in Youth-Onset Type 2 Diabetes: What Are the Early and Late Predictors?
Authors: Zeitler Philip , El Ghormli Laure , Arslanian Silva , Caprio Sonia , Isganaitis Elvira , Kelsey Megan K , Weinstock Ruth S , White Neil H , Drews Kimberly 
Published: April 2022

Abstract

Objective
We examined predictors of early and late loss of glycemic control in individuals with youth-onset type 2 diabetes, as well as predictors of short-term deterioration in youth from the Treatment Options for type 2 Diabetes in Adolescents and Youth (TODAY) study.

Methods
Demographic, physical, and biochemical measures at baseline and 48 months, and change over time, were examined in 584 participants separated into those with loss of glycemic control (sustained HbA1c ≥ 8%) before 48 months or at 48 months or later, and those who remained in control until the end of the study (median 6.8 years). Univariate and multivariate models, and receiver operating characteristic curve analyses were performed.

Results
Approximately 45% of youth remained in control at 48 months; of these, 30% subsequently lost glycemic control prior to the end of follow-up. Predictors of early loss of glycemic control included baseline HbA1c, C-peptide index, oral disposition index, proinsulin, and proinsulin to insulin ratio. Predictors of late loss included baseline measures of insulin secretion and change in HbA1c and insulin processing at 48 months. A baseline HbA1c cutoff of ≥ 6.2% was optimally predictive of loss of glycemic control at any time, while an absolute rise in HbA1c &gt; 0.5% related to loss of glycemic control within 3 to 6 months.

Conclusion
This analysis demonstrates that youth with type 2 diabetes at risk for loss of glycemic control, including impending rapid deterioration, can be identified using available clinical measures, allowing for closer monitoring of at-risk youth, and facilitating the design of research on better therapeutic options.
The New System of Mexican Migration: The Role of Entry Mode–Specific Human and Social Capital
Authors: Wassink Joshua , Massey Douglas S. 
Published: April 2022

Abstract
Between 2000 and 2020, undocumented migration declined, temporary labor migration rose, and legal permanent residents arrived at a steady pace—together creating a new system of Mexico–U.S. migration based on the circulation of legal temporary workers and permanent residents. Drawing on data from the U.S. Department of Homeland Security and the Mexican Migration Project, we specify multinomial event-history models to predict the likelihood of departure on first and later trips via four entry categories: no documents, noncompliant tourist visas, temporary work visas, and legal residence visas. The models reveal how the accumulation of entry mode–specific social and human capital powered a system of undocumented migration that emerged between 1965 and 1985, and how that system deteriorated from 1985 to 2000. After 2000, employers took advantage of new visa categories to recruit legal temporary workers, leading to the accumulation of migration-related human and social capital specific to that mode of entry and the emergence of a new system of Mexico–U.S. migration.
Queering Tupac Amaru II
Authors: Roper Danielle M. 
Published: April 2022

AbstractThis study examines the queering of Tupac Amaru in Javier Vargas Sotomayor's La Falsificación de las Túpac (The Falsification of Tupac) to discern how travestismo (transvestism) functions as a methodology and epistemology for working on and against the symbols that underwrite national identity. This essay treats falsification as a central precept of a travesti methodology by paying close attention to the role of fiction, falsity, and fabrication in the production of the hero and the nation. Roper argues that travestismo not only exposes the constructedness of its original but also functions as a tool of dissent and as a space for staging an encounter with the possible.
Preoperative Sonographic Prediction of Limited Axillary Disease in Patients with Primary Breast Cancer Meeting the Z0011 Criteria: an Alternative to Sentinel Node Biopsy?
Authors: Radosa Julia Caroline , Solomayer Erich-Franz , Deeken Martin , Minko Peter , Zimmermann Julia Sarah Maria , Kaya Askin Canguel , Radosa Marc Philipp , Stotz Lisa , Huwer Sarah , Müller Carolin , Karsten Maria Margarete , Wagenpfeil Gudrun , Radosa Christoph Georg 
Published: April 2022

Abstract
Purpose
To assess the accuracy of preoperative sonographic staging for prediction of limited axillary disease (LAD, one or two metastatic lymph nodes) and to identify factors associated with high prediction–pathology concordance in patients with early-stage breast cancer meeting the Z0011 criteria.

Materials and Methods
Patients treated between January 2015 and January 2020 were included in this retrospective, multicentric analysis of prospectively acquired service databases. The accuracy of LAD prediction was assessed separately for patients with one and two suspicious lymph nodes on preoperative sonography. Test validity outcomes for LAD prediction were calculated for both groups, and a multivariate model was used to identify factors associated with high accuracy of LAD prediction.

Results
Of 2059 enrolled patients, 1513 underwent sentinel node biopsy, 436 primary and 110 secondary axillary dissection. For LAD prediction in patients with one suspicious lymph node on preoperative ultrasound, sensitivity was 92% (95% CI 87–95%), negative predictive value (NPV) was 92% (95% CI 87–95%), and the false-negative rate (FNR) was 8% (95% CI 5–13%). For patients with two preoperatively suspicious nodes, the sensitivity, NPV, and FNR were 89% (95% CI 84–93%), 73% (62–83%), and 11% (95% CI 7–16%), respectively. On multivariate analysis, the number of suspicious lymph nodes was associated inversely with correct LAD prediction ([OR 0.01 (95% CI 0.01–0.93), p ≤ 0.01].

Conclusions
Sonographic axillary staging in patients with one metastatic lymph node predicted by preoperative ultrasound showed high accuracy and a false-negative rate comparable to sentinel node biopsy for prediction of limited axillary disease.
Analysis of diagnosing neonatal respiratory distress syndrome with lung ultrasound score
Authors: Huang Lie , Ye Dan , Wang Jianhui 
Published: April 2022

Objectives: To investigate the diagnostic effect of lung ultrasound on neonatal respiratory distress syndrome (NRDS) and to analyze the clinical application value of pulmonary ultrasound score.
Methods: Sixty-five NRDS babies who were diagnosed in our hospital from August 2019 to October 2020 were selected as the observation group, and 65 healthy babies were selected as the control group. Children in the two groups underwent lung ultrasound examination. The characteristic signs of lung ultrasound in the two groups were analyzed, and the detection rate of various signs and lung ultrasound score were compared between the two groups.
Results: The main manifestations of lung ultrasound in NRDS children were pulmonary parenchyma, abnormal pleural line, blurred or disappeared A line, pleural effusion, white lung, and weak or disappeared pulmonary pulsation; the lung ultrasound scores of different positions in the observation group were higher than those in the control group, and the differences were statistically significant (P<0.05). The detection rates of signs such as lung parenchyma, abnormal pleural line, disappeared A line, diffuse pulmonary edema, and air bronchogram in the observation group were significantly higher than that in the control group (P<0.05), and there was no significant difference in the detection rate of the sign of B line existence between the two groups (P>0.05).
Conclusion: Lung ultrasound has a high diagnostic value in diagnosing NRDS, and lung ultrasound score can evaluate the severity of NRDS in babies to further optimize the diagnosis results, which has important clinical significance.
doi: https://doi.org/10.12669/pjms.38.5.5202
How to cite this:Huang L, Ye D, Wang J. Analysis of diagnosing neonatal respiratory distress syndrome with lung ultrasound score. Pak J Med Sci. 2022;38(5):---------. doi: https://doi.org/10.12669/pjms.38.5.5202
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Monitoring of awake bruxism by intelligent app
Authors: Velásquez Ron Byron , Mosquera Cisneros Verónica , Pazmiño Troncoso Pamela , Rodríguez Tates María , Alvares Lalvay Eddy , Chauca Bajaña Luis , Ordoñez Balladares Andrea 
Published: April 2022

Background. Bruxism is a topic of much controversy and is continually debated in the field of dentistry due to the multifaceted clinical relationship that results in painful conditions and consequences to patients. The aim of this review was to determine the effectiveness of a smartphones app in monitoring awake bruxism. Methods. PROSPERO (registration number: CRD42021271190). The eligibility criteria were as followed: observational studies, case–control studies, studies that reported odds ratios, and studies on awake bruxism. The following keywords were searched: [smartphones apps] AND [apps] AND [awake bruxism], OR [sleep bruxism], OR [sleep hygiene], OR [parasomnias], AND [habits]. Results. All the authors agree that the use of the smartphone app allows controlled awake bruxism monitoring. The results also show that the two bruxism are interactive, having negative synergism and substantially increasing the risks of temporomandibular joint pain and temporomandibular disorders. Discussion. In the AB it was possible to identify 70% symptoms through the different frequencies of behavior provided by the App, within the present technological tools have become daily in young and adult population. The app is effective and easy to use by patients, effectively limiting biases the time of evaluation.