bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bcl-xL Is a Key Mediator of Apoptosis Following KRASG12C Inhibition in KRASG12C-mutant Colorectal Cancer
Authors: Khawaja Hajrah , Briggs Rebecca , Latimer Cheryl H. , Rassel Mustasin , Griffin Daryl , Hanson Lyndsey , Bardelli Alberto , Di Nicolantonio Frederica , McDade Simon S. , Scott Christopher J. , Lambe Shauna , Maurya Manisha , Lindner Andreas U. , Prehn Jochen H.M. , Sousa Jose , Winnington Chris , LaBonte Melissa J. , Ross Sarah , Van Schaeybroeck Sandra 
Published: October 2022

Abstract
Novel covalent inhibitors of KRASG12C have shown limited response rates in patients with KRASG12C-mutant (MT) colorectal cancer. Thus, novel KRASG12C inhibitor combination strategies that can achieve deep and durable responses are needed. Small-molecule KRASG12C inhibitors AZ’1569 and AZ’8037 were used. To identify novel candidate combination strategies for AZ’1569, we performed RNA sequencing, siRNA, and high-throughput drug screening. Top hits were validated in a panel of KRASG12CMT colorectal cancer cells and in vivo. AZ’1569-resistant colorectal cancer cells were generated and characterized. We found that response to AZ’1569 was heterogeneous across the KRASG12CMT models. AZ’1569 was ineffective at inducing apoptosis when used as a single agent or combined with chemotherapy or agents targeting the EGFR/KRAS/AKT axis. Using a systems biology approach, we identified the antiapoptotic BH3-family member BCL2L1/Bcl-xL as a top hit mediating resistance to AZ’1569. Further analyses identified acute increases in the proapoptotic protein BIM following AZ’1569 treatment. ABT-263 (navitoclax), a pharmacologic Bcl-2 family inhibitor that blocks the ability of Bcl-xL to bind and inhibit BIM, led to dramatic and universal apoptosis when combined with AZ’1569. Furthermore, this combination also resulted in dramatically attenuated tumor growth in KRASG12CMT xenografts. Finally, AZ’1569-resistant cells showed amplification of KRASG12C, EphA2/c-MET activation, increased proinflammatory chemokine profile and cross-resistance to several targeted agents. Importantly, KRAS amplification and AZ’1569 resistance were reversible upon drug withdrawal, arguing strongly for the use of drug holidays in the case of KRAS amplification. Taken together, combinatorial targeting of Bcl-xL and KRASG12C is highly effective, suggesting a novel therapeutic strategy for patients with KRASG12CMT colorectal cancer.
Temporal Relationship Between Arterial Stiffness and Systolic Blood Pressure Under Intensive or Standard Control: A Post Hoc Analysis of the STEP Trial
Authors: Ling Qianhui , Song Qirui , Bai Jingjing , Wu Shouling , Zhang Weili , Chen Mulei , Cai Jun 
Published: October 2022

Background:
Whether or not the temporal relationship between arterial stiffness and systolic blood pressure (SBP) is affected by how strictly SBP is controlled (intensive, 110–<130 mm Hg; standard, 130–<150 mm Hg) has been unclear.

Methods:
The temporal relationship between brachial-ankle pulse wave velocity (baPWV) and SBP was assessed using a cross-lagged panel model in the 5369 participants in the STEP trial (Strategy of Blood Pressure Intervention in the Elderly Hypertensive Patients) for whom baseline and follow-up baPWV data were complete.

Results:

Patients with arterial stiffening (baPWV≥1800 cm/s) at baseline were significantly less likely to achieve their target SBP than those without arterial stiffening in the intensive and standard treatment groups (65.17% versus 76.91% and 97.33% versus 98.96%, respectively, both
P
<0.05). The standardized regression coefficient from baseline baPWV to follow-up SBP was 0.05 (95% CI, 0.02–0.08;
P
<0.001) and that from baseline SBP to follow-up baPWV was insignificant from zero (β=−0.007 [95% CI, −0.03 to 0.02];
P
=0.62) after adjustment for confounders.

Conclusion:
Arterial stiffening consistently preceded SBP in the intensive and standard groups, and it led to difficulty in reaching target SBP, particularly in the intensive treatment group. Besides, assignment to intensive treatment group was associated with an attenuation of the age-related increase in baPWV at 3-year follow-up.

Registration:

URL:
https://www.clinicaltrials.gov
; Unique identifier: NCT03015311.
The Significance of the Motif of the King in 4QMMT
Authors: Klukowski Michal 
Published: October 2022

Abstract
The paper discusses four motifs of the king in 4QMMT: (1) blessings and curses in the history of the monarchy (C 18–20); (2) call to reflect on the deeds of the kings of Israel (C 23b–24); (3) call to study the writings related to King David (C 10); and (4) call to reflect on David’s deeds (C 25–26). The analysis of these motifs leads to the conclusion that they were not only intended to show the addressee the kings of Israel as role models, but by intertwining them with quotations from the Book of Deuteronomy, they were also to serve as historical evidence that would testify to the veracity of the blessings and curses foretold in the Law (Deut 28–30), and as a result, underline the seriousness of the situation in which the Law was still not properly obeyed in Israel.
Concrete Buys Time
Authors: Irvine Richard D.G. , Bevan Anne 
Published: October 2022

Abstract
Recent engagements with deep time within anthropology have urged an expansion of our time horizons in order to confront the contemporary ecological crisis. Here, we explore this theme by considering concrete’s material properties as a substance that reveals the troubled relationship between the present and deep time. We combine discussion of the life cycle of concrete in Orkney, Scotland, with reflection on sculptural interventions that seek to capture concrete’s character as both solid and fluid—the pouring of concrete has the potential to congeal a fleeting moment in time. Yet, recognising the impact of the production of concrete, understood at the geological level, we see a pernicious feedback loop: attempts to secure the land/water boundary contribute to the climatic changes which threaten those very environments. The task of tracing concrete’s place within the geological record illustrates both the challenge and the necessity of recognising humanity within deep time.
On the Ecopoetics of Temporal Discernment
Authors: Rigby Kate 
Published: October 2022

Abstract
In this short article, I explore the ways in which literary studies, and in particular, the study of ecopoetry and ecopoetics, can contribute to current engagements with the temporal horizon of ‘deep’, geological, time. Drawing on the concept of ‘temporal discernment’ advanced by environmental philosopher, James Hatley, I argue for the cultivation of an appreciation for plural temporalities (including the historical, ethical, immemorial, creaturely, contemplative and prophetic, alongside the geological and evolutionary), the lineaments of which I trace here in Diane Pacitti’s poetry collection, Dark Angelic Mills centred around the multi-layered history of the post-industrial, multi-cultural Cathedral town of Bradford in England.
Between Racism and Universalism
Authors: Koren Israel 
Published: October 2022

Abstract
This paper explores two central poles of Rudolf Steiner’s thought: racial/ethnic hierarchy (primitive/degenerate/earthly vs. advanced/sophisticated/spiritual) and universalism (of the “I” and the eventual disappearance of racial and ethnic differentiations in the future). The relationship between these two poles has been fiercely debated by scholars, anthroposophists, and lay people over the past twenty years. In contrast to previous studies on Steiner’s rac(ial)ism that have focused on how it can be contextualized within the philosophy, sciences, and Theosophy of his day and followed its manifestations in different stages of his life, this article takes an internalist approach, examining how Steiner’s racial doctrine is integral to his teachings as a whole. Demonstrating that the ostensible dichotomy between the two poles on the conceptual plane is false, the article also points to the two incongruous and irreconcilable aspects of Steiner’s personality: while taking a strong stand against racism he also disseminated extremist racial views.
Aenigmatic Names
Authors: Frantsouzoff Serge A. 
Published: October 2022

Abstract
The corruption of personal names in Arabic, especially those borrowed from foreign languages (such as Greek), goes back to the specific features of its script and often results in the multiplication of historical figures and hagiographic characters. In this article, is analysed the orthography and functional features of the name of the Jewish king of Ḥimyar Yōsēf called Y(w)sf/’s’r/Yṯ’r in the South Arabian epigraphic documentation and Yūsuf Dhū Nuwās in Arab Islamic tradition. The article deals with several sobriquets and epitheta, under which he is known in Eastern Christian historiographical and hagiographical traditions and some of them have received new interpretations. The derivation of the unusual Ethiopic form of his name Ṭamnus is attested in the Chronicle of John of Nikiu. It can be identified as “Dimnos” found in the Chronography of John of Malalas (c. 491–578). The same name in the form Dīmnōn appears in the Chronicle of Ps.-Dionysius of Tel-Maḥrē (sed. 818–45). In the article it is cautiously suggested that these three similar names came into being as a result of a corruption of the Greek “δαιμων” or “demon”. The title nəgusä aḥzab, which the Jewish monarch bears in the Chronicle of John of Nikiu, proves to be very close to the original title of Yōsēf, the mlk/kl/’š‘b-n, viz. “the king of all the communities” (Arab. malik al-shu‘ūb). The author proposes an assumption that this is rare evidence of the influence of South Arabian historical tradition upon Byzantine historiography.
Trophic niche size and overlap in temperate forest land snails are affected by their lifestyle and body size
Authors: Němec Tomáš , Líznarová Eva , Horsák Michal 
Published: October 2022

Abstract
Land snails represent a large diversity of species in the forest floor. Some species prefer to stay in the leaf litter, while others like to climb up vegetation. They are considered generalist herbivores/decomposers. Although the exact trophic position of most species is often difficult to determine, a low rate of trophic niche partitioning within an assemblage is assumed. We compared isotopic niche sizes and overlaps between and within four local land snail assemblages using stable isotope Bayesian ellipses. We found significant differences in trophic niche size (expressed by corrected standard ellipse area) as a function of body size and lifestyle. We hypothesised that the larger niche size of smaller and/or arboreal snail species is due to their limited mobility and the presence of spatially structured food resources. In contrast, a broad and similar mixture of leaf litter sources results in a homogeneous diet for individuals of larger, highly mobile, epigean species, i.e., smaller niche size. We documented multiple overlaps of isotopic niches between species within an assemblage, although arboreal species exhibited slightly different niche positions, indicating specific diets. When comparing all pairwise combinations, we found that isotopic niches of species using different lifestyle did not overlap, in contrast to species using similar lifestyle. In addition, the trophic niches of opportunists with respect to lifestyle were intermediate between those of species from the outermost categories. Our results fit the general concept of variable and overlapping trophic niches in co-occurring snail species. However, we were able to demonstrate differences in species that rarely occupy the same microhabitat.
Nationalizing the Ottomans and Ottomanizing the Turks
Authors: Michael Michalis N. 
Published: October 2022

Abstract
This article analyses how the ruling party in Turkey and President Recep Tayyip Erdoğan are trying to construct a new Turkish nation on an ideological level through a different reading of Ottoman history. In this process, a special reading of Ottoman history comes to the fore after the Kemalist state tried to undermine its importance. The article studies the importance of the ideological use of history and the instrumentalization of the events of the Ottoman past by the administration in Turkey. This effort is analysed as an attempt to prove the historical continuity of the Turkish nation, which includes the long Ottoman history that the Kemalist state challenged. It is argued that Erdoğan is in essence nationalizing and religionizing the Ottoman Empire as a Turkish and Islamic empire and Ottomanizing the contemporary Turkish nation as one that should rely on the religious aspect of its identity.
Villain or Hero? Shifting Views of Abdülhamid ii and His Era in Republican Turkey
Authors: Grigoriadis Ioannis N. 
Published: October 2022

Abstract
Narratives and representations of the past in the present sometimes tell us more about the present than the past itself. Views of Ottoman history have varied in republican Turkey, according to political and ideological circumstances. The era of Sultan Abdülhamid ii has remained one of the most contested ones. While classic republican Turkish historiography has identified the Hamidian era with Oriental despotism, blamed it for the collapse of the Ottoman Empire, but exonerated it for the killings of Armenians, recent historical interest in the era has been revisionist. Some scholars offer a more balanced evaluation of the Hamidian period, while other approaches move to the opposite extreme, aggrandizing Sultan Abdülhamid ii and his era and also pointing to alleged Young Turk treason. These approaches have coincided with a re-evaluation of the ideological foundations of republican Turkey and the re-emergence of a cult of personality in mainstream Turkish politics.
An Island of (Dis)Agreement Within Modern Turkish Historiography: the Chronic Conquest(s) of Cyprus Through the Turkish Past, Present and Future
Authors: Yıldırımtürk Okcan 
Published: October 2022

Abstract
This article discusses how the Turkish historical narratives of Cyprus evolved in mutually antagonistic and constitutive ways from the 1920s to the 1970s. Based on a genealogical perspective and a thematic focus on the conquest(s) of the island, it ultimately questions how and why Islamist authors approached the island’s history and in what ways they reproduced and/or challenged the official historiography and ruling ideology of the Turkish Republic. In doing so, the article attempts to contextualize the development and transformation of modern Turkish historiography, standing at the juncture of possible pasts, presents and futures, along with identity formations, ideologies and political upheavals.
„Es gibt keine ‚idiographische‘ Wissenschaft“ Alois Riehl und der Methodendualismus der Süd-Westdeutschen Neukantianer (Tome 144, 7e Série, n° 1-2, (2023))
Authors: Hlade Josef 
Published: October 2022

Zusammenfassung
Dieser Aufsatz widmet sich Riehls Auseinandersetzung mit empirischen Sozial- und Humanwissenschaften. Der Neukantianer Riehl wurde in diesem Zusammenhang bisher kaum berücksichtigt. Ein großes Interesse verdient er sich aufgrund seiner Ablehnung des Ansatzes der Südwestdeutschen Schule des Neukantianismus, die sich aus seiner erkenntnistheoretischen Position ergibt. Er sprach sich gegen einen Methodendualismus zwischen Geistes- und Naturwissenschaften und für eine wertfreie Geschichtswissenschaft aus. Ähnlich wie Karl Lamprecht fordert er eine strikte Trennung zwischen Wissenschaft und Weltanschauung und die Implementierung einer kausal-genetischen Betrachtungsweise. Aus diesem Grund trat er in den späten 1880er Jahren als wichtiger Förderer und Wegbereiter der Ethnologie in Freiburg in Erscheinung, förderte in Berlin Anfang der 1900er Jahre die Wissenschaftstheorie wesentlich und erwarb sich schließlich auch als ein Förderer der experimentellen Psychologie Verdienste.
Multiple origins of Southeastern Sinitic tsh- corresponding to Middle Chinese s- or sr-
Authors: KWOK Bit-Chee 
Published: October 2022

Abstract
There are nearly 20 words with Middle Chinese onsets s- or sr- whose reflexes in modern Southeastern Sinitic (Mǐn, Southern Wú, Hakka, and Gàn) are aspirated affricates. Examples of such words include sī 撕 ‘to tear,’ sù 粟 ‘grain,’ xiān 鮮 ‘fresh,’ and xīng 星 ‘star.’ This paper reveals that there are at least four origins for these correspondence sets, three of which can be connected with Old Chinese. The remaining is a self-innovation of the ancestor of the Southeastern Sinitic group. In this sense, the reflexes of modern Southeastern Sinitic can be taken as an important additional material in the reconstruction of Old Chinese.
Perceiving Corruption in Tanzania
Authors: Kessy Ambrose T. 
Published: October 2022

Abstract
The difficulties associated with conventional corruption measurements as employed in comparative country evaluations concern the accuracy they provide in assessing and explaining corruption. These conventional measures regard corruption as a one-dimensional phenomenon (quantified by a single score) which varies in incidence but not in form between countries. Such measures frequently associate corruption with bribery. But this one-dimensional composite measurement of corruption is insufficient to capture corruption in less developed economies, particularly in Africa, where corruption is perceived as taking many forms. Transparency International’s assessment of Tanzania (recently graduated by the World Bank to middle-income country status), demonstrates the misleading consequences of such composite, ubiquitous metrics. Perceptions of corruption as well as the diverse activities classifiable as corrupt practices are complex concepts; so any single indicator applied internationally may fail to accurately quantify these concepts; nor will such measures help to identify potential anti-corruption intervention strategies.
Non-Recognition of Territorial Acquisitions by the Use of Armed Force: The Status of Jerusalem before Italian Courts
Authors: Iovane Massimo 
Published: October 2022

Abstract
This article comments upon two recent decisions of the Tribunal of Rome concerning the international legal status of Jerusalem. The issue before the court was whether rai, Italy’s public service broadcasting company, had aired false information by presenting the city as the capital of Israel. After summarizing the key aspects of the historical process which led to the current arrangement of Jerusalem, the article highlights that the international regulation of the city’s legal status mainly depends on the customary principle of non-recognition of territorial acquisitions by the use of armed force. It then analyses how the non-recognition regime affects the international legal status of Jerusalem. In this regard, it is argued that the position – taken by the Tribunal of Rome in the first of its two decisions – that Jerusalem is not recognized as the capital of Israel under international law seems excessive. The non-recognition regime only affects the status of East Jerusalem, while Israeli sovereignty over West Jerusalem appears largely uncontroversial. Therefore, defining Jerusalem as the “disputed” capital of Israel – as done by the tribunal’s second decision – is a more accurate depiction of the complexities surrounding Jerusalem’s status, which should eventually be defined through negotiations between the involved parties.
Italy’s Contribution to a More Robust International Architecture for the cbrn Legal Landscape
Authors: Casolari Federico 
Published: October 2022

Abstract
During the last decades, the landscape of Chemical, Biological, Radiological and Nuclear (“cbrn”) threats has significantly evolved. In the light of this, it does not come as a surprise that several initiatives have recently been put in place both at universal and regional level to deal with such threats, trying to introduce a more robust legal framework for cbrn events. The present article provides a global assessment on the role played by Italy in identifying and/or strengthening international obligations related to cbrn events. In the light of the piecemeal cbrn legal landscape, the article will not discuss each and every initiative put in place by Italy; rather, the analysis will be focused on the contribution given by Italy to multilateral initiatives which are likely to produce cross-cutting or horizontal impacts on the discipline.
Violation of Public Policy as a Ground for Non-Recognition of Foreign Judgments – The Case of Judgments Preceded by a Mareva-Type Freezing Order
Authors: Franzina Pietro 
Published: October 2022

Abstract
This note examines a ruling by the Corte di Cassazione concerning procedural public policy as a ground for non-recognition of foreign judgments. The Corte di Cassazione held that a foreign judgment may not be denied recognition in Italy on the sole ground that the court of origin previously granted an in personam interim measure restraining the respondent from dealing with its assets, whereas, under Italian law, asset preservation measures necessarily operate in rem. According to the Court, the public policy defence can only succeed if the proceedings before the court of origin, considered as a whole, were tainted by a serious violation of fundamental procedural rights. Having found no evidence of such a violation in the circumstances, the Court concluded that the foreign judgment concerned was eligible for recognition. The ruling of the Corte di Cassazione confirms of the restrictive approach to public policy which the Court itself developed throughout its previous case law, and will plausibly serve as a model for future decisions regarding procedural public policy.
International Child Abduction and the 1980 Hague Convention in Practice: The Biran Case
Authors: Queirolo Ilaria 
Published: October 2022

Abstract
With its Decision of 29 November 2021 (No. 7918/21), the Supreme Court of Tel Aviv has ruled on the case of Eitan Biran, the child who survived the crash disaster of the “Mottarone” cable car in Italy. After the accident, the child was entrusted to his aunt, appointed as legal guardian. However, a few months later, the child was unexpectedly conducted to Israel by his paternal grandfather. The Israeli Family Court and District Court, appointed for the return of the child according to the 1980 Hague Convention on the Civil Aspects of International Child Abduction, have ordered the immediate repatriation in Italy.
The decision of the District Court was upheld by the Supreme Court, whose decision represents a good example of correct application of the 1980 Hague Convention. Acknowledging that the guiding principle of the Convention is “zero tolerance for child abductions”, the Court has established that the habitual residence of the child was in Italy and that the transfer to Israel was in breach of the custody rights of the legal guardian according to Articles 3 and 5 of the Convention: in fact, the institute of tutore legale in Italy attributes to a person the responsibility of a child, a circumstance that in this case derived from a judicial decision. Moreover, the Israeli Supreme Court has adhered to a strict interpretation of the exceptions stated in Articles 12(2), 13 and 20, none of which resulted applicable to the case at hand.
Legal Effects of the Ratification by Italy of the Amendments to the icc Statute on Aggression
Authors: Prosperi Luigi 
Published: October 2022

Abstract
Through the adoption of Law No. 202/2021 on the ratification of the amendments to the Statute of the International Criminal Court, among other things Italy accepted the icc’s jurisdiction over the crime of aggression. This comment argues that with respect to proprio motu investigations and States Parties’ referrals, the scope of such jurisdiction depends on the interpretation of Articles 15bis(4) and 15bis(5) of the Statute. The ratification has two additional implications. First, conducts committed by Italian nationals in the context of international military operations may be scrutinized by the icc. Second, the Italian legislator should enact domestic legislation criminalizing the crime of aggression in order not to incur the violation of an obligation to cooperate with the Court pursuant to Part 9 of the Statute.