bluuebunny/crossref_metadata_2025_split huggingface dataset:
Myocardial Infarction in the Postpartum Period
Authors: Shakhova O. B. , Kuzmina I. M. , Gvindzhiliya T. R. , Damirov M. M. , Muradyan N. A. , Parkhomenko M. V. 
Published: September 2022

The study objective Is to present a clinical observation, describe the diagnostics and treatment of acute transmural myocardial infarction in a patient on the 8th day after childbirthMaterial and methods A 31-year-old patient was hospitalized 3 hours after the onset of the disease on the 8th day after urgent spontaneous delivery at 38-39 weeks of gestation with a clinic of acute myocardial infarction in the intensive care unit. Based on the data of anamnesis, complaints, physical examination, results of instrumental and laboratory examination, the following clinical diagnosis was made: ischemic heart disease: acute transmural myocardial infarction of the anterior wall, septum and apex of the left ventricle; atherosclerosis of the aorta and coronary arteries. On an emergency basis, the patient underwent coronary angiography, pronounced atherosclerotic changes in the coronary arteries were revealed: acute occlusion of the anterior interventricular artery in the middle third, stenosis of the diagonal branch up to 70% in the orifice, stenosis of the circumflex branch up to 70% in the middle third, extended stenosis up to 79% in the middle third of the right coronary artery.Results The patient underwent percutaneous coronary intervention (pci) on a symptom-dependent artery: mechanical recanalization and stenting of the anterior descending artery (ada) by a drug-eluting stent.Conclusion An increase in the incidence of acute coronary syndrome in pregnant women and postpartum women requires the development of an algorithm for additional examination of late reproductive age patients at the stage of pregnancy planning, in case of identification of possible risk factors for the development of cardiovascular diseases — observation of a cardiologist during pregnancy and in the postpartum period.
Fragile X Syndrome: Medical Considerations and Stomatological Aspects for Dental Treatment
Authors: Amaral Cristhiane Olívia Ferreira Do , Silva Nilzete Santana , Guedes Alexsander , Amaral Mariana Olívia Ferreira Do , Pizi Eliane Cristina Gava , Straioto Fabiana Gouveia 
Published: September 2022

The objective of this study was to carry out a literature review in order to elucidate general and oral physical aspects, behavioral disorders, medical considerations and discuss considerations about the dental approach in individuals with Fragile X Syndrome (FXS) as well as to provide surgeons dentists with greater care clarification towards these patients. A literature review has been carried out in the following databases: Virtual Health Library (VHL) –MEDLINE– PubMed , SciELO and in the Capes database Journals. The descriptors used were: Fragile X Syndrome, Oral Health, Systemic Condition, Behavioral Disorders. The main phenotypic characteristics found in the literature were: prominent ears, elongated face, strabismus, hyperextensible joints , macrorchidism , mitral valve prolapse, seizures. Fragile X Syndrome oral characteristics are: mandibular prognathism, atresic and deep palate, enamel hypoplasia, malocclusion, presence of biofilm due to unestablished hygiene habits, caries, calculus and gingivitis. Cognitive deficit, autism spectrum disorder, anxiety disorder and hyperactivity are behaviors found in FXS which bring difficulties for these patients to undergo a dental approach. The dental surgeon must be up-to-date and aware of the medical and behavioral conditions of FXS individuals and, thus, offer an adequate and safe dental approach. Systemic, behavioral and oral abnormalities require an initial dental treatment planning.
Alpha1-antitrypsin deficiency and cardiovascular disease: questions and issues of a debated relation
Authors: Pini Laura , Giordani Jordan , Ciarfaglia Manuela , Pini Alessandro , Arici Marianna , Tantucci Claudio 
Published: September 2022

Alpha1-antitrypsin (AAT) is one of the major inhibitors involved in protease/antiprotease homeostasis, and it is mainly produced by hepatocytes and pulmonary epithelial cells. Its deficiency, called alpha1-antitrypsin deficit (AATD), leads to severe hepatic and respiratory issues. Also, AAT is released into the bloodstream providing systemic anti-inflammatory effects. Apart from acting as an acute-phase anti-inflammatory protein, it can be a biomarker for monitoring disease evolution. A reduced or defective production leads to a loss of anti-inflammatory function, protease–antiprotease imbalance and cellular engorgement due to polymers deposition, with system-wide repercussions. This review aims to evaluate AATD condition in the major vessels of the head and neck, thoracic and abdominal districts. Also, a dedicated focus on autoimmune vascular diseases will be provided.
A critical revision of the main literature findings starting from the 1980s until now has been performed. Studies conducted over the years have provided several contradictory pieces of evidence. Most authors acknowledge the protective and anti-inflammatory AAT role on the vascular endothelium. However, correlations between AATD and major arteries, cerebral and cardiovascular conditions, and autoimmune diseases remain unclear. Most studies recognize the role of AATD in vascular diseases but only as a cofactor inducing cellular and tissue structure impairments. However, this condition alone is not enough to determine new disease onset.
Due to the opposing results reported over the years, there is still a considerable lack of knowledge on the role covered by AATD in vascular diseases. A renewed interest in this research field should be encouraged to grant new solid evidence and validate the putative role of AATD screening and replacement therapy as useful diagnostic and treatment tools.
Comparison of Woody Species Diversity and Population Structure Along Disturbance Gradient in Babile Elephant Sanctuary, Ethiopia
Authors: Hussein Abdulbasit , Dejene Sintayehu Workeneh , Aschalew Abebe 
Published: September 2022

Abstract
The study was conducted at Babile Elephant Sanctuary (BES), to identify and document the list of woody species, and to analyze the diversity, richness, evenness, and population structural status of woody species. The diversity of plant species and population structure of woody species were analyzed from 60 quadrats, each with 20 m x 20 m for trees and 5 m x 5 m for shrubs and climbers, using systematic sampling methods with three levels of disturbances regime, namely, low disturbed (LD), moderately disturbed (MD) and heavily disturbed (HD) sites. Vegetation parameters such as diameter at breast height (DBH), richness, evenness, and density of woody species were recorded. Shannon Weiner Diversity Index was used to analysis vegetation diversity and evenness. A total of 61 woody species were identified in the study area that falls within 29 families and 38 genera of which 50.8 % were shrubs, 39.3 % were trees and the rest 9.83 % were climbers. Fabaceae was represented by the highest number of species (14 species = 22.90). The highest plant species richness was recorded from the low disturbed sites, followed by moderately disturbed and heavily disturbed sites respectively. The population density of vegetation was significantly higher in the MD site, followed by the LD site. The total basal area of LD, MD, and HD were 27.2, 19.8, and 11.2 m2/ha, respectively. LD site had significantly (P= 0.04) highest Shannon’s diversity index value (3.21) than the others two disturbance levels. This result suggests that the consequence of human-induced disturbance on woody species diversity and population structure appeared to be negative depending on the type and intensities of the disturbances.
PREWEDDING PHOTO HYPERREALITY IN BALI
Authors: Surya Dinata Ramanda Dimas , Ardika I Wayan , Darma Putra I Nyoman , Gde Pujaastawa Ida Bagus 
Published: September 2022

The practice of Hindu marriages in Bali has been unknowingly hit by the name pop culture, or in lifestyle terms as pre-wedding photos. The wedding customs of the Hindu community in Bali as a local tradition or local culture that previously did not recognize the term pre-wedding photos began to be inserted and produced through materialistic discourses and practices. Pre-wedding photos encourage the presence of an element of hyperreality from the millennial lifestyle that is mixed by digital and virtual spaces, as a trend of 'futuristic', 'replica', and 'copy' which has actually surpassed reality itself since its presence in 1996. The research is located in Bali and uses qualitative methods. The problems studied include (1) why there is a tendency for hyperreality in pre-wedding photos; (2) what are the forms of hyperreality of pre-wedding photos in Bali; (3) what are the implications of the hyperreality of pre-wedding photos in Bali. In general, this research is to deconstruct what is behind the pre-wedding photo phenomenon and reveal facts that can provide an overview of knowledge and understanding of its relationship with the hyper-reality of pre-wedding photos in Bali. The analysis of this research uses several theories, namely hypersemiotic theory, deconstruction theory, and commodification theory. The results show that (1) the factors that cause hyperreality in pre-wedding photos are lifestyle factors, commercial industry factors, globalization factors, and the factors of negotiation between photographers and clients (brides); (2) forms of hyperreality in pre-wedding photos in Bali show visual engineering, cultural fabrication, love accentuation, hybrid identity, parody and reinterpretation of style; (3) the implications of the hyperreality of pre-wedding photos in Bali show three implications, namely the implications of aesthetic innovation, the implications of an unstable commercial industry, and the implications of shifting meaning. What is presented in the pre-wedding photo phenomenon is a celebration of desire (symbol sales) in various manipulative ways and various supporting media.
Keywords: Hyperreality, pre-wedding photos, Hindu community, Bali
UNDERSTANDING THE IDEOLOGY OF CULTURAL DUALISM IN THE CAR-SHAPE SHRINE ARCHITECTURE AT PALUANG TEMPLE, NUSA PENIDA, BALI
Authors: Gede Suyoga I Putu , Suarka I Nyoman , Ardhana I Ketut , Suwena I Wayan 
Published: September 2022

This study focuses on the ideology of cultural dualism in the VW Beetle and Jeep Jimny as two car-shape shrines at Pura Paluang Nusa Penida, Bali. These two worship altars are to worship Ida Ratu Gede Ngurah Sakti and Hyang Mami or called Shiva-Durga in the pantheon of the gods of Hinduism. The architectural design of the two car-shape shrines are unique and different from most mainstream Balinese Hinduism. This shows the existence of a collective view that has ideological nuances. This qualitative study with descriptive analysis, obtained data through observation, interviews, library research and documentary techniques. The informants were determined using the purposive and snowball technique. All the data were analyzed in order to draw conclusions. The result of the study shows that the dualism of cultural ideology has inspired the development of worship altars in the form of the car-shape shrine. Primarily representing the two poles of culture. East-traditional culture is the most intense-sacred, with the profane on the side of modern-western culture. The mimicry strategy and the hybrid mechanism are very dominant in shaping the ultimate architectural identity. Socially, it legitimizes the dominant political power, identity, belief, orientation of the collective action of the people of Nusa Penida.
Keywords: ideology of cultural dualism, car-shape shrine, Paluang Temple Nusa Penida Bali
POTENSI SIANIDIN POLY(LACTIC-CO-GLYCOLIC ACID)-POLYETHYLEN GLYCOL YANG DIMODIFIKASI FUSED FOLLICLE UNTUK MENINGKATKAN SENSITIVITAS DAN SEKRESI INSULIN DALAM MENANGANI PENYAKIT DIABETES MELITUS TIPE 2
Authors: Gorintha Adrian Wiryanata , Debora Stevina , Chandra Natasya Eiffeline 
Published: September 2022

ABSTRACT
Introduction: Type 2 diabetes mellitus is one of the four priority non-communicable diseases according to WHO. WHO data in 2015 showed that as many as 415 million people in the world suffer from type 2 diabetes mellitus. Even in Indonesia in 2013, the prevalence of people with diabetes has increased to 6.9%. Currently, the most common treatment for type 2 diabetes mellitus is the administration of metformin. However, long-term administration will cause lactic acidosis and kidney damage. Because of this, new alternatives are needed that minimize the side effects, for example by using herbal ingredients. Cyanidin is a natural flavonoid that has the effect of increasing insulin sensitivity and secretion.

Discussion: Cyanidin has the potential to increase insulin receptor sensitivity and increase insulin secretion. To increase insulin sensitivity, cyanidin can inhibit the downregulation of Glut4 expression and decrease the level of RBP 4 expression. As an increase in insulin secretion Cyanidin increases the expression of GLUT2, Kir6.2, and Cav1.2 genes that play a role in insulin secretion. Unfortunately, Cyanidin has low bioavailability and is unstable. Therefore, Cyanidin encapsulation will increase the availability of cyanidin in the blood and is easily concentrated into pancreatic cells
Conclusion: The Fc-modified Cyanidin PLGA-PEG combination has the potential to be a new alternative in the treatment of type 2 diabetes mellitus
Keywords: Type 2 Diabetes Mellitus, Cyanidin, Fc-modified Cyanidin PLGA-PEG
Potensi Kuersetin Terenkapsulasi PLGA sebagai Terapi dalam Penatalaksanaan Kanker Payudara
Authors: Sadhu Putra Putu Risya , Prasetyo Aizar Vesa , Wahyuni Putu Sinta Elix 
Published: September 2022

Introduction: Breast cancer is the main type of cancer involved in the death of women in the world. This cancer is one of the most common cancers suffered worldwide with an incidence of about two million cases per year. Quercetin is a type of flavonoid active compound. This active compound induces cell apoptosis and affects the cell cycle so that it has potential in the treatment of breast cancer. However, the effect of quercetin has limitations due to its water-soluble nature, unstable chemical structure, and difficulty to absorb from the gastrointestinal tract so that its bioavailability is poor. Nano-formulation of quercetin by utilizing Poly (lactic-co-glycolic acid) PLGA can be an option in increasing the anti-cancer effect of quercetin.
Discussion: The results of a literature review on various literature studies showed that quercetin encapsulated by PLGA showed a significant increase in apoptotic activity (early, late) by 53.37% and 6.78% compared to control and PLGA, respectively. Compared with PLGA without quercetin, quercetin encapsulated by PLGA was able to have excellent anti-cancer activity by reducing cell viability up to 40% in the concentration range of 0-2 g. /mL.
Conclusion: Therefore, PLGA-encapsulated quercetin therapy in the management of breast cancer has promising potential, so further research is needed.
POTENSI SUPLEMENTASI SMALL-QUANTITY LIPID-BASED NUTRIENT PRENATAL DAN POSTNATAL SEBAGAI PENCEGAHAN ANEMIA DEFISIENSI BESI PADA ANAK DI BAWAH USIA DUA TAHUN
Authors: Yusuf Muhammad , Atalia Arila , Cresma Avisa Cetta 
Published: September 2022

Pendahuluan: Anemia Defisiensi Besi (ADB) merupakan masalah kesehatan masyarakat di Indonesia. Dampak utama ADB pada anak adalah peningkatan risiko gangguan kognitif dan psikomotor permanen yang dapat menyebabkan penurunan kualitas hidup di masa dewasa. Rekomendasi suplementasi zat besi untuk ibu hamil dan anak memiliki efek samping yang tidak nyaman dan menyebabkan kepatuhan terapi yang kurang optimal. Small quantity lipid-based nutrient supplement (SQ-LNS) dikembangkan sebagai upaya fortifikasi besi baru untuk wanita hamil dan menyusui serta anak-anak. Tujuan tinjauan pustaka ini adalah menganalisis efektivitas suplementasi SQ-LNS untuk mencegah ADB pada anak di bawah usia dua tahun.
Metode: Tinjauan pustaka dibuat dengan kriteria PICOS dan studi klinis yang sesuai dengan kriteria inklusi diekstraksi dari database "PUBMED", "Cochrane", dan "Europe-PMC".
Hasil dan Pembahasan: 10 studi diinklusi dalam tinjauan pustaka. Biomarker ADB seperti Hemoglobin, serum Ferritin, dan soluble transferrin receptor (sTfR) secara signifikan lebih baik pada kelompok SQ-LNS dibandingkan dengan kontrol. Prevalensi anemia, defisiensi besi, dan anemia defisiensi besi lebih rendah pada kelompok SQ-LNS dibandingkan dengan kontrol. SQ-LNS juga meningkatkan kadar Hepcidin dan meningkatkan pertumbuhan serta perkembangan anak ditunjukkan oleh skor length-for-age z score, skor weight-for-age z scores, dan skor perkembangan lokomotor yang lebih tinggi, serta prevalensi stunting yang lebih rendah.
Kesimpulan: Suplementasi SQ-LNS pada ibu hamil, ibu menyusui, dan anak di bawah dua tahun berpotensi untuk mengoptimalkan kadar Hb, Ferritin serum, sTfR, serta mencegah ADB pada anak dan mendukung tumbuh kembang anak.
GAMBARAN PERILAKU MASYARAKAT TENTANG ISOLASI MANDIRI CORONAVIRUS DISEASE (COVID-19) DI WILAYAH KERJA PUSKESMAS PAUH TAHUN 2021
Authors: Mahendika Devin , Chandra Multazam Fahreza , Andini Astri Dwi , Tasyriqiyyah Mai Ismil Husni , Widanti Naila , Mustika Sylfia , Burhan Ida Rahmah , Julita Ema 
Published: September 2022

Pendahuluan: Coronavirus Disease-19 (COVID-19) merupakan penyakit yang disebabkan oleh SARS-CoV-2. Positivity rate COVID-19 Puskesmas Pauh hingga Agustus 2021 mencapai 34,95%. Sebagian besar masyarakat Pauh yang terkonfirmasi COVID-19 melaksanakan isolasi mandiri.
Metode: Penelitian ini menggunakan pendekatan logis dan politis yang bersifat deskriptif dengan rancangan cross-sectional. Penelitian dilakukan dari bulan Agustus-September 2021 di Kelurahan Cupak Tangah, Limau Manis Selatan, dan Koto Luar. Data penelitian diperoleh dengan cara pengisian kuesioner responden dan wawancara terpimpin.
Hasil: Masalah yang ditemukan dengan menggunakan metode Hanlon adalah tingginya positivity rate COVID-19 di Puskesmas Pauh. Hal ini disebabkan oleh beberapa faktor, seperti kurangnya pengetahuan masyarakat tentang COVID-19 dan isolasi mandiri, kurangnya kesadaran dalam menjalankan protokol kesehatan, kurangnya kepedulian dan stigma negatif terhadap masyarakat terkonfirmasi COVID-19, belum ketatnya pengawasan protokol kesehatan oleh lintas sektor, dan kendala dalam pembelian Alat Pelindung Diri (APD) standar.
Pembahasan: Promosi kesehatan dengan modul dipilih berdasarkan kondisi demografis dan geografis dari wilayah Pauh dengan tujuan memberikan pemahaman terhadap isolasi mandiri. Kegiatan lain yang dilakukan adalah sosialisasi dan evaluasi berupa pre dan post test dengan target masyarakat, tenaga kesehatan, dan pejabat ruang lingkup wilayah Pauh.
Simpulan: Solusi terhadap tingginya positivity rate COVID-19 di wilayah kerja Puskesmas Pauh adalah membentuk modul isolasi mandiri dengan menggunakan alur Plan, Do, Check, dan Action (PDCA), pembuatan modul ini dapat menjadi luaran dalam membantu memperbaiki perilaku masyarakat dan mengedukasi masyarakat untuk berperilaku yang baik sesuai kaidahnya.
Kata kunci: COVID-19, isolasi mandiri, modul, Puskesmas
KARAKTERISTIK MI TINGGI ANTIOKSIDAN DARI DAUN KELOR (Moringa oleifera L.) DAN DAUN BELUNTAS (Pluchea indica L.)
Authors: Wulantika W. , Supriyanto Supriyanto , Fakhry M. 
Published: September 2022

Tanaman kelor (Moringa Oleifera) dan beluntas (Pluchea Indica) mengandung antioksidan yang tinggi sehingga bisa dimanfaatkan sebagai makanan fungsional. Tujuan dari penelitian ini adalah untuk mengetahui karakteristik mi yang dibuat dari eksrak daun kelor dan beluntas. Penelitian ini menggunakan rancangan acak lengkap non faktorial dengan 5 variasi formula pembuatan mi. Paramater yang diamati meliputi analisis warna, antioksidan dan uji sensoris. Data hasil penelitian dianalisis menggunakan uji F pada taraf signifikasi 5% apabila ada beda nyata dilanjutkan dengan uji DMRT?5% dengan bantuan sofware SPSS versi 21. Hasil penelitian menunjukkan bahwa penggunaan daun kelor dalam bentuk bubur dapat meningkatkan kandungan antioksidannya dengan nilai 11,63.%.
Pengaruh Konten Mobile Legends di TikTok terhadap Popularitas Games Mobile Legends
Authors: Eleanor Sherren , Junaidi Ahmad 
Published: September 2022

Currently, the Tiktok application is one of the most widely used social media platforms for digital marketing activities. Tiktok is a social media platform that provides a place for its users to be able to express and be creative through video content. This Tiktok account with the name @kbggwp is an example of a Tiktok account being used as a promotional medium and creating Mobile Legends content as a medium for popularizing the online game Mobile Legends: Bang Bang. The account contains various information and various interesting video content about Mobile Legends. This study aims to determine how much influence Mobile Legends content on Tiktok has on the popularity of the Mobile Legends game with variable X namely Mobile Legends content on Tiktok and variable Y namely the popularity of Mobile Legends game. In this study, researchers used research theories and concepts, namely marketing communication theory, branding, popularity, Tiktok social media and online games. The research method used is quantitative and a survey of 100 respondents as a sample with a questionnaire research instrument. Based on the results of the study, it was found that there was a positive and significant effect of the Mobile Legends content variable on Tiktok and the Y variable, namely the popularity of the Mobile Legends game by 56.8%.
Aplikasi Tiktok merupakan salah satu media sosial yang saat ini banyak digunakan dalam berbagai kegiatan pemasaran. Aplikasi Tiktok dapat digunakan oleh para penggunanya dengan menciptakan konten-konten video yang bervariasi. Akun Tiktok dengan nama @kbggwp ini menajdi salah satu contoh akun Tiktok yang digunakan sebagai media promosi dan membuat konten Mobile Legends sebagai media mempopulerkan game online Mobile Legends: Bang Bang. Akun tersebut berisi mengenai berbagai informasi serta berbagai konten video menarik seputar Mobile Legends. Penelitian ini bertujuan untuk mengetahui seberapa besar pengaruh konten Mobile Legends di Tiktok terhadap popularitas game Mobile Legends dengan variabel X yakni konten Mobile Legends di Tiktok dan variabel Y yakni popularitas game Mobile Legends. Pada penelitian ini, peneliti menggunakan teori dan konsep penelitian, yakni teori komunikasi pemasaran, branding, popularitas, media sosial Tiktok dan game online. Metode penelitian yang digunakan berupa kuantitatif serta survei terhadap 100 responden sebagai sampel dengan instrument penelitian kuesioner. Berdasarkan hasil penelitian, ditemukan bahwa terdapat pengaruh positif dan signifikan dari variabel konten Mobile Legends di Tiktok dan variabel Y yakni popularitas game Mobile Legends sebesar 56,8%.