bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hét lehetséges kutatás a társadalomtudomány működéséről
Authors: Nagy Péter Tibor 
Published: January 2022

Összefoglaló. A tanulmány a szerző Négy lehetséges kutatás a
felsőoktatókról, című 2007-es írását továbbgondolva háromféle
forrásra, s az ezek közötti három különböző fajta kapcsolatokra építő kutatási
tervet vázol fel. Az egyik kutatás a pozíciók (bírálati, vezető, beosztotti
pozíciók) elemzését végezné el. A másik kutatás a multipozicionalitás hatásait
vizsgálja, megkülönböztetve a munkahelyen belüli nem tudományos, munkahelyen
kívüli nem tudományos és munkahelyen kívüli tudományos pozíciókat. A harmadik
kutatás a folyóiratok világát elemezné, ahogy a többi esetben is
megkülönböztetve a folyóiratok irányítását, a folyóiratok publikációra
használását, a manifeszt vitát, a lektori aktivitást és a tematikus számok
szerkesztését. A „reflexiók” blokkban az idézetek és a kritikák fő funkciójáról
a szerző tudományos térben történő pozícionálásáról folytatnánk kutatást. A
társszerzőségre vonatkozó kutatás indítóhipotézise szerint három fő motivációja
lehet ennek: közös munka, szövetségi viszony és mester-tanítvány viszony
kifejezése. A civil szervezeteket, tudományos társaságokat a folyóiratokhoz
hasonló módon az irányítók és egyszerű tagként használók kettősségében írjuk le,
de itt szerepet kap a írásos világ ellenőrizhetőségétől különböző szóbeliség
világa, mely egy külső körnek is utat nyit. A hatalmi erőkifejtés tudományos
termeléshez közvetlenül nem kapcsolódó fajtái a pénzosztás, díjak osztása és az
adatok birtoklása.
Summary. Continuing the author’s 2007 Educatio
paper Four Possible Researches on Academic Staff, the study
outlines a research plan based on three sources and three different types of
relationships between them. The first research would analyzed the positions
(exeminer, leader, employed positions). The second research examines the effects
of multipositionality, distinguishing the non-scientific positions within
academic workplace, non-scientific positions outside academic workplace,
scientific positions outside academic workplace The third research would analyze
the world of journals, as in the other cases, distinguishing between the
management of journals, the use of journals for publication, the manifesto
debate, the lectorship activity, and the editing of thematic issues. In the
“reflections” block, we would conduct research on the main function of
quotations and critiques on positioning the author in the scientific space.
According to the initial hypothesis of co-authorship, there may be three main
motivations for this: working together, expressing a covenant relationship, and
expressing a master-student relationship. In the chapter of „civil societies” we
describe scientific societies in the duality of managers and simple „users”, but
– contrary to the world of journals – here the non controlled oralism of
conferences plays a role, which also opens the way for an outside circle. Types
of power effort not directly related to scientific production are the
distribution of money, the sharing of medals, and the control over data.
Felsőoktatásban oktatók digitális kompetenciáinak fejlesztési lehetőségei
Authors: Dringó-Horváth Ida , T. Nagy Judit , Weber Andrea 
Published: January 2022

Összefoglaló. A tanulmány fókuszában a digitális pedagógiai
kompetencia fejlesztésének jelentősége áll. Ennek eredményeként egy olyan
komplex intézményi oktatásfejlesztési elképzelésről ad számot, melynek elemei –
előzetes igény- és kompetenciamérés, fejlesztési folyamat, illetve
visszacsatolás, azaz a fejlesztés hatékonyságának mérése – egymásba fonódva,
egymásra épülve képesek hatékonyan biztosítani a felsőoktatók szisztematikus,
reflektált oktatásinformatikai fejlesztését. A tanulmány az egyes elemek
részletes bemutatása és létjogosultságának indoklása mellett beszámol a rendszer
pilot kipróbálásának első eredményeiről és a tapasztalatokra épülő fejlesztési
tervekről is.
Summary. The article focuses on the significance of developing the
competence of digital pedagogy. Following that, we will propose a complex plan
for institutional educational development, the elements of which (preliminary
needs and competence analysis, the development process itself, and feedback,
i.e. measuring the efficacy of development) will be able to successfully
guarantee, by building on each other in an intertwined fashion, the systematic
and reflective ICT development of teachers in higher education. Apart from
thoroughly introducing and giving a rationale for each element, the study will
also highlight the results of the first pilot run and, by drawing conclusions
from the pilot’s experiences, plans for improvement.
The behavior of apricot kernel oil body and proteins during in vitro gastric and intestinal digestion
Authors: Kancabas Kilinc Aslı , Karakaya Sibel 
Published: January 2022

In this study, an apricot kernel milk suspension was prepared, for which Hacıhaliloğlu-type raw and roasted apricot kernels were used. Protein, total lipid, and ash contents of apricot kernels and apricot kernel milk were determined. Palmitic acid, oleic acid, and linoleic acid were considered as major fatty acids according to gas chromatography. During in vitro gastrointestinal digestion, the proteins of raw and roasted apricot kernel milk were hydrolyzed and pepsin-resistant proteins were determined. No difference was recorded between the pancreatic lipase penetration in the oil–water interface of oil bodies of both milk types.
Analysis of rice microbial communities under different storage conditions using culture-dependent and -independent techniques
Authors: He Xiaoying , Liu Hairong , Lv Chong , Wang Feng , Zhao Chaoqun , Tao Rui , Li Jianpeng , Liu Zhu , Du Lihui 
Published: January 2022

Rice is a staple food for over half of the world’s population, and fungal spoilage in stored rice may occur when the moisture content and temperature are conducive. Aspergillus sp. and Penicillium sp. are the most harmful toxigenic species that produce harmful mycotoxins. Molds pose a potential threat to public health and cause a huge economic loss. Therefore, it is of great importance to find out how molds multiply in rice. This study focused on the isolation and identification of fungi presented in rice and their evolution in rice with different moisture contents stored for varying periods of time and under different temperatures. Mold community was detected every month using the culture-dependent and -independent method of polymerase chain reaction-denaturing gradient gel electrophoresis (PCR-DGGE). Significant differences were detected by the traditional culture method under different storage conditions. For potato dextrose agar (PDA) media, high temperature and moisture were suitable for the dominant strains including Penicillium aurantiogriseum and Penicillium oxalicum. In particular, P. oxalicum competitively inhibited the other fungi. For Rose Bengal medium, no difference was observed under different storage conditions, and only typical strains such as Aspergillus candidus and Alternaria were detected. PCR-DGGE identified some uncultured strains such as Trichoderma sp. and Cladosporium sp., the dominant strains and the flora diversity such as Aspergillus restrictus and Eurotium athecium. These results indicated that storage conditions greatly shape fungal growth. This study provides a foundation for the evolution of fungal flora in rice during storage in China and may help in developing biological control methods to prevent mold contamination in rice.
Integrin α5 Is Regulated by miR-218-5p in Endothelial Progenitor Cells
Authors: Liu Jialing , Li Yi , Lyu Lingna , Xiao Liang , Memon Aliza A. , Yu Xin , Halim Arvin , Patel Shivani , Osman Abdikheyre , Yin Wenqing , Jiang Jie , Naini Said , Lim Kenneth , Zhang Aifeng , Williams Jonathan D. , Koester Ruth , Qi Kevin Z. , Fucci Quynh-Anh , Ding Lai , Chang Steven , Patel Ankit , Mori Yutaro , Chaudhari Advika , Bao Aaron , Liu Jia , Lu Tzong-Shi , Siedlecki Andrew 
Published: January 2022

Significance Statement
Kidney endothelial cells are sensitive to hypoxic injury. This cell type expresses integrin α5 (ITGA5), which is essential to the Tie2 signaling cascade. The microRNA miR-218 is known to increase after hypoxia, but the microRNA’s role in regulating ITGA5 protein synthesis is unclear. In this study, the authors found that miR-218-5p specifically binds to ITGA5 mRNA in human kidney-derived endothelial progenitor cells (EPCs). In an animal model of ischemia/reperfusion injury, cells pretreated with an miR-218-5p mimic were delivered efficiently, whereas an animal model containing an miR-218-2 deletion specific to angioblasts resulted in kidney dysgenesis and impaired migration of mouse kidney-derived EPCs. Understanding the regulation of prominent signaling pathways in EPCs may inform optimization of therapeutic techniques for addressing kidney endothelial cell injury.

Background
Endothelial cell injury is a common nidus of renal injury in patients and consistent with the high prevalence of AKI reported during the coronavirus disease 2019 pandemic. This cell type expresses integrin α5 (ITGA5), which is essential to the Tie2 signaling pathway. The microRNA miR-218-5p is upregulated in endothelial progenitor cells (EPCs) after hypoxia, but microRNA regulation of Tie2 in the EPC lineage is unclear.

Methods
We isolated human kidney-derived EPCs (hkEPCs) and surveyed microRNA target transcripts. A preclinical model of ischemic kidney injury was used to evaluate the effect of hkEPCs on capillary repair. We used a genetic knockout model to evaluate the effect of deleting endogenous expression of miR-218 specifically in angioblasts.

Results
After ischemic in vitro preconditioning, miR-218-5p was elevated in hkEPCs. We found miR-218-5p bound to ITGA5 mRNA transcript and decreased ITGA5 protein expression. Phosphorylation of 42/44 MAPK decreased by 73.6% in hkEPCs treated with miR-218-5p. Cells supplemented with miR-218-5p downregulated ITGA5 synthesis and decreased 42/44 MAPK phosphorylation. In a CD309-Cre/miR-218-2-LoxP mammalian model (a conditional knockout mouse model designed to delete pre-miR-218-2 exclusively in CD309+ cells), homozygotes at e18.5 contained avascular glomeruli, whereas heterozygote adults showed susceptibility to kidney injury. Isolated EPCs from the mouse kidney contained high amounts of ITGA5 and showed decreased migratory capacity in three-dimensional cell culture.

Conclusions
These results demonstrate the critical regulatory role of miR-218-5p in kidney EPC migration, a finding that may inform efforts to treat microvascular kidney injury via therapeutic cell delivery.
The effect of Kathak Dance Movement on Balance and Gait in Parkinson’s Disease- An Experimental Study
Authors: Metange Deepika , Waghule Loveleen , Deo Medha 
Published: January 2022

INTRODUCTION: Difficulties with gait and balance are common among individuals with Parkinson's disease (PD). Several different exercise programs have been suggested to address balance and gait problems to improve the quality of life and patient compliance with PD exercises. Dance may be an effective tool for addressing these problems because it includes key elements of dynamic balance, can improve functional mobility, and is, at the same time, enjoyable and engaging. OBJECTIVES: The purpose of this study was to assess the effect of Kathak dance movement in addition to conventional physiotherapy on balance and gait in Parkinson's disease patients. METHODS AND MATERIALS: A total of 44 patients diagnosed with Parkinson's disease were included in the study with a mean age of 63.20 + 8.5 years. Patients were randomly divided into two groups, the control group received conventional physiotherapy, and the experimental group received the same along with Kathak dance movements which were Tatkar and Gatnikas. The intervention was given three days a week for four weeks. Pre-and post-assessment for balance and gait was assessed by scales including TUG test, Tinetti, FOG-Q, and UPDRS-III. The within-group comparison was made using Wilcoxon Signed rank test and between the group using the Mann Whitney U test to see the effect of treatment intervention. Results: The mean age of participants for both groups were 64.18±8.53 and 62.23±6.21, respectively. The comparison showed a significant difference in TUG, Tinetti, and FOG-Q within the group with p<0.01. The between-group comparison showed no significant difference between the two treatments interventions with p=0.361 for TUG, p=0.479 for Tinetti, and p= 0.73 for FOG-Q. CONCLUSION: Both groups showed similar improvements in balance and gait in PD patients. Thus, we conclude that the Kathak Dance movement can be used to complement conventional physical therapy exercises.
Understanding and attenuating pandemic-related disruptions: a plan to reduce inequalities in child development
Authors: Côté Sylvana M. , Geoffroy Marie-Claude , Haeck Catherine , Ouellet-Morin Isabelle , Larose Simon , Chadi Nicholas , Zinszer Kate , Gauvin Lise , Mâsse Benoit 
Published: January 2022

AbstractThe Secretary General of the United Nations described the impact of COVID-19-related school closures as a “generational catastrophe.” What will be the legacy of the 2020–2021 pandemic-related disruptions in 5, 10, 20 years from now, as regards education and well-being of children and youth? Addressing the disproportionate impact on those growing up in socio-economically disadvantaged areas or on those with pre-existing learning challenges is key to sustainable recovery. This commentary builds on the four literature reviews presented in thisSpecial Section on a Pandemic Recovery Plan for Childrenand proposes strategies to understand and attenuate the impact of pandemic-related lockdown measures. Importantly, we need a monitoring strategy to assess indicators of child development in three areas of functioning: education and learning, health, and well-being (or mental health). Surveillance needs to begin in the critical prenatal period (with prenatal care to expectant parents), and extend to the end of formal high school/college education. Based on child development indicators, a stepped strategy for intervention, ranging from all-encompassing population-based health and education promotion initiatives to targeted prevention programs and targeted remedial/therapeutic interventions, can be offered. As proposed in the UN plan for recovery, ensuring healthy present and future generations involves a concerted and intensive intersectoral effort from the education, health, psychosocial services, and scientific communities.
Pigmented skin neoplasm in a child: сomplex case report and review of the literature
Authors: Belysheva T.  S. , Nasedkina T.  V. , Orlova K. V. , Vishnevskaya Y. V. , Kletskaya I. S. , Khestanov D. B. , Doroshenko M. B. , Mikhaylova S. N. , Senderovich A.  I. , Emelyanova M. A. , Abramov I. S. , Demidov L. V. , Aliev M. D. 
Published: January 2022

Introduction. Skin melanoma in children is a very rare disease that differs in many aspects from skin melanoma in adults. The conventional criteria for clinical diagnostics of melanoma observed in adults are often absent in children and adolescents, making it difficult to make a diagnosis on time.Objective. The aim of the study is to assess the clinical significance of various diagnostic criteria in the analysis of a rare case of congenital pigment skin neoplasm in a child.Materials and methods. The clinical case of a congenital melanocytic lesion in a wrist joint area in a girl 5 months old.During the primary diagnosis, an ultrasound examination was carried out. The tumor excision was performed with replacement of defect using moved skin flap. Histological, genetic and cytogenetic (fluorescent hybridization in situ, FISH) examination of a tumor sample was carried out.Results. The histological examination revealed areas of cellular atypia with high mitotic activity and the presence of pathological mitoses. According to FISH results, an increase in the copy of the RREB1 gene was observed in the sample, which may indicate amplification of this chromosome region. Genetic testing revealed a Q61K mutation in the NRAS gene.Conclusion. Despite the presence of histological features of neoplasm malignancy and ambiguous FISH results, the described case should be considered as congenital nevus with atypical proliferative nodes based on combination of clinical data (early age at the time of surgery, expansive growth pattern, multiplicity of nodes, lack of necrosis, long relapse-free period).
Prognostic factors in surgical treatment of the lungs metastases of soft tissue sarcoma
Authors: Akhmedov B. B. , Kononets P. V. , Artamonova E. V. , Musaev E. R. , Gerasimov S. S. , Bokhyan B.  . , Valiev A. K. , Sofronov D.  I. , Stilidi I.  S. 
Published: January 2022

Objective. The aim of this study is to improve the results of surgical treatment of lung metastases of soft tissue sarcomas, to analyze the factors that may affect the effectiveness of surgical treatment.Materials and methods.The study included 80 patients with metastases of bone sarcomas in the lungs, who received treatment in the period from 2000 to 2013. Among the patients there were 42 (48,5 %) men and 38 (51,5 %) women.The median age at diagnosis was 33 years (range 17 to 75). The majority of soft tissue sarcomas were represented by malignant fibrous histiocytoma (27,5 %) and synovial sarcoma (28,5 %). Almost all patients (96 %) underwent chemotherapy before surgery for lung metastases. The indication for surgery in most cases (52,5 %) was metastases in the lungs as the only manifestation of the disease. Most often, operations were performed with unilateral lung lesions (67,5 %).Results. Atypical lung resections 58 (72 %) were the most frequently performed volume of surgical intervention, pneumonectomy, bilobectomy and lobectomy were used in 17 (22 %) cases. Combined resections were performed in six patients. Postoperative complications were observed in 6 (7,5 %) patients. The radicality of the operations performed in the study group was 93 % in the R0 volume, in the R1 volume, 4 % of the operations were performed, in the R2 volume, 1 patient was operated on. The most frequent postoperative complication was pneumonia, one patient died in the early postoperative period from complications of surgery. The median follow-up in the study group was 49,2 months (from 3,5 to 239 months). The overall 5-year survival rate in the study group was 41,5 %. Five-year overall survival was more than 30 % higher in the group of patients who had less than 3 metastatic lesions at baseline. Only the following factors have a direct impact on OS indicators: the number and size of metastatic foci, radical removal of metastatic foci, the effect of previous chemotherapy, and the timing of the development of metastatic lesions. In our study, there were also no differences in OS and PFS depending on the surgical approach used.Conclusion.Surgical treatment is currently fully justified and the only really effective treatment method that can lead to longer-term survival in patients with metastases of sarcomas in the lungs, despite the fact that some metastases have a clear resistance to all types of conservative therapy, while The best treatment results are achieved in the presence of a long disease-free interval (DFI), a small number of metastases and their removal in the R0 volume.
The cooperation agreements within the belt and road initiative: The european common commercial policy at crossroads
Authors: Martínez San Millán Carmen 
Published: January 2022

To carry out Chinese investments in third countries under the Belt and Road Initiative, the China is currently concluding numerous cooperation agreements called Memorandums of Understanding with its objective States, including European Union Member States. These Memorandums of Understanding are international agreements, but not international treaties as such, which implies that these documents may not lead to rights and obligations under International Law. However, every Memorandum of Understanding signed between China and a European Member States should be interpreted in accordance with European Law. The problem is that Member States are presumably violating different instruments of this legal framework as well as the European Union Common Commercial Policy, which is an exclusive competence of this international organization, if we interpret that these cooperation agreements are masking free trade agreements. This paper aims to analyse this possible interpretation and its consequences for the European Union, as these agreements entail a weakening of the European trade and investment power and put the European Common Commercial Policy at crossroads.
Received: 10 May 2021Accepted: 05 November 2021
ОБРАЗОВАНИЕ ТРЕЩИН ГИДРАВЛИЧЕСКОГО РАЗРЫВА ПЛАСТА В КАРБОНАТНЫХ СЛОЖНОПОСТРОЕННЫХ КОЛЛЕКТОРАХ С ЕСТЕСТВЕННОЙ ТРЕЩИНОВАТОСТЬЮ
Authors: Мартюшев Дмитрий Александрович , Пономарева Инна Николаевна , Филиппов Евгений Владимирович , Ли Ювэй 
Published: January 2022

Ссылка для цитирования: Образование трещин гидравлического разрыва пласта в карбонатных сложнопостроенных коллекторах с естественной трещиноватостью / Д.А. Мартюшев, И.Н. Пономарева, Е.В. Филиппов, Ли Ювэй // Известия Томского политехнического университета. Инжиниринг георесурсов. – 2022. – Т. 333. – № 1. – С. 85-94
Актуальность исследования обусловлена тем, что наличие естественной трещиноватости в карбонатных сложнопостроенных коллекторах является основным фактором, который влияет на форму и распространение сети трещин гидравлического разрыва пласта. В таких случаях, когда трещина гидравлического разрыва пласта сталкивается с естественной трещиноватостью, может иметь место различный характер их взаимодействия, например смещение, пересечение и т. п. Следовательно, проведение гидравлического разрыва пласта в сложнопостроенных карбонатных коллекторах, характеризующихся наличием естественной трещиноватости, может привести к образованию не симметричной трещины в ее классическом понимании, а их сложной сети. На основании полевых наблюдений (микросейсмический мониторинг и исследование пустотного пространства горных пород) установлена разная степень сложности трещин гидравлического разрыва пласта: от простой относительно плоской единичной трещины до достаточно сложной сети трещин. Цель: оценка образования сложных сетей трещин гидравлического разрыва пласта в карбонатных коллекторах с естественной трещиноватостью. Объект: сложнопостроенная карбонатная залежь с системой естественных трещин. Методы: анализ промысловых, технологических, гидродинамических данных и результатов микросейсмического мониторинга в процессе проведения гидравлического разрыва пласта. Результаты. Установлено, что проведение гидравлического разрыва в сложнопостроенных карбонатных коллекторах зачастую не приводит к образованию трещины в классическом ее понимании – два крыла, распространяющиеся симметрично от ствола скважины, что подтверждено результатами анализа графиков кривых восстановления давления в диагностических билогарифмических координатах. Трещины гидравлического разрыва пласта могут распространяться в пласт непосредственно от скважин – объектов воздействия (классическое представление), либо через существующую сеть естественных трещин, расположенных в зоне дренирования. Для вовлечения в процесс фильтрации значительного количества естественных трещин и других видов пустотности в процессе проведения гидравлического разрыва пласта жидкость разрыва целесообразно закачивать при низких скоростях. Контроль за развитием трещин гидроразрыва должен основываться на достоверной информации о естественной трещиноватости коллектора до проведения мероприятия, а регулирование – посредством мониторинга динамики давления и скорости закачки, что подтверждает результаты исследований.