bluuebunny/crossref_metadata_2025_split huggingface dataset:
Accuracy of International Classification of Diseases, 10th Revision Codes for Identifying Sepsis: A Systematic Review and Meta-Analysis
Authors: Liu Bonnie , Hadzi-Tosev Milena , Liu Yang , Lucier Kayla J. , Garg Anchit , Li Sophie , Heddle Nancy M. , Rochwerg Bram , Ning Shuoyan 
Published: December 2022

OBJECTIVES:
Administrative databases are increasingly used in research studies to capture clinical outcomes such as sepsis. This systematic review and meta-analysis examines the accuracy of International Classification of Diseases, 10th revision (ICD-10), codes for identifying sepsis in adult and pediatric patients.

DATA SOURCES:
We searched MEDLINE, EMBASE, Web of Science, CENTRAL, Epistemonikos, and McMaster Superfilters from inception to September 7, 2021.

STUDY SELECTION:
We included studies that validated the accuracy of sepsis ICD-10 codes against any reference standard.

DATA EXTRACTION:
Three authors, working in duplicate, independently extracted data. We conducted meta-analysis using a random effects model to pool sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV). We evaluated individual study risk of bias using the Quality Assessment of Diagnostic Accuracy Studies tool and assessed certainty in pooled diagnostic effect measures using the Grading of Recommendations Assessment, Development, and Evaluation framework.

DATA SYNTHESIS:
Thirteen eligible studies were included in the qualitative synthesis and the meta-analysis. Eleven studies used manual chart review as the reference standard, and four studies used registry databases. Only one study evaluated pediatric patients exclusively. Compared with the reference standard of detailed chart review and/or registry databases, the pooled sensitivity for sepsis ICD-10 codes was 35% (95% CI, 22–48, low certainty), whereas the pooled specificity was 98% (95% CI: 98–99, low certainty). The PPV for ICD-10 codes ranged from 9.8% to 100% (median, 72.0%; interquartile range [IQR], 50.0–84.7%). NPV ranged from 54.7% to 99.1% (median, 95.9%; interquartile range, 85.5–98.3%).

CONCLUSIONS:
Sepsis is undercoded in administrative databases. Future research is needed to explore if greater consistency in ICD-10 code definitions and enhanced quality measures for ICD-10 coders can improve the coding accuracy of sepsis in large databases.
Development and Evaluation of a Cervical Cancer Screening Training Program for Midwives in Japan
Authors: Oishi Tokiko , Miyauchi Akito , Yamada Manabu , Nakane Naoko , Manome Yuko , Kajihara Yoko , Hanley Sharon J.B. , Nishioka Emiko , Mikami Yumiko 
Published: December 2022

Background:
In Japan, cervical cancer incidence has increased over the last decade and screening coverage is extremely low (35.8%). In 2016, the Japanese government allowed nursing professionals to perform cervical screening for the first time if instructed to do so by a gynecologist. Following this, a training program was developed for midwives to perform cervical screening.

Objective:
To evaluate a training program for Japanese midwives to perform cervical screening.

Methods:
Eight experienced midwives participated at 1 medical center in November 2019. After a lecture, skills-lab and 3-week practice using a manikin, midwives who passed the skills-check proceeded to the practicum for routine screening. After passing the practicum, each midwife took 20 samples under indirect supervision. Evaluations by supervising gynecologists and 160 screened women, as well as midwives’ self-reports were analyzed.

Results:
The pass rate was 86%. In 21 (13%) of 160 cases, midwives needed assistance from a gynecologist to locate the cervix, including 5 cases which were taken over by a gynecologist. None of the samples were unsatisfactory. Women’s evaluation of midwives as screeners was both positive and high.

Conclusions:
This training program enabled experienced Japanese midwives to take adequate samples while methods of evaluation should be elaborated. Women were highly satisfied with midwives performing cervical screening.

Implications for Practice:
Task shifting to midwives may be an important policy approach to improving cervical screening coverage.

Foundational:
This study was the first in Japan to give foundation to task shifting of cervical screening from physicians to midwives.
Exercise increases arterial stiffness independent of blood pressure in older Veterans
Authors: Pewowaruk Ryan J. , Hein Amy J. , Hansen Kristin M. , Barnes Jill N. , Chesler Naomi C. , Korcarz Claudia E. , Gepner Adam D. 
Published: December 2022

Background:
Exercise-induced changes in arterial function could contribute to a hypertensive response to exercise (HRE) in older individuals. We performed the present analysis to define the acute arterial stiffness response to exercise in ambulatory older adults.

Methods:
Thirty-nine Veterans (>60 years old), without known cardiovascular disease, participated in this study, including 19 Veterans who were hypertensive (70.8 ± 6.8 years, 53% women) and 20 Veterans who were normotensive (72.0 ± 9.3 years, 40% women). Arterial stiffness parameters were measured locally with carotid artery ultrasound and regionally with carotid–femoral pulse wave velocity (cfPWV) before and during the 10 min after participants performed a Balke maximal exercise treadmill stress test.

Results:
The arterial stiffness response to exercise was similar for control and hypertensive participants. At 6 min postexercise, cfPWV was significantly increased (Δ1.5 ± 1.9 m/s, P = 0.004) despite mean blood pressure (BP) having returned to its baseline value (Δ1 ± 8 mmHg, P = 0.79). Arterial mechanics modeling also showed BP-independent increases in arterial stiffness with exercise (P < 0.05). Postexercise cfPWV was correlated with postexercise SBP (r = 0.50, P = 0.004) while baseline cfPWV (r = 0.13, P = 1.00), and postexercise total peripheral resistance (r = −0.18, P = 1.00) were not.

Conclusion:
In older Veterans, exercise increases arterial stiffness independently of BP and the arterial stiffness increase with exercise is associated with increased postexercise SBP. BP-independent increases in arterial stiffness with exercise could contribute to a HRE in older adults.
Efficacy of exercise in patients with pulmonary fibrosis: A systematic review and meta-analysis
Authors: Gao Yan , Zhao Lijing , Yang Zhaoyun , He Kang , Zhang Tingyu , Yi Jiang 
Published: December 2022

Background:
Pulmonary fibrosis (PF) is easily caused by a variety of factors, resulting in dyspnea, exertion and movement intolerance. This systematic review aims to synthesize evidence on exercise training during rehabilitation for PF in order to improve patients’ exercise capacity, quality of life, and lung function.

Methods:
Retrieved from the Cochrane Library, Web of Science, PubMed, Scopus and Embase from inception until April 2022. Participants: patients with PF; Intervention measures: exercise training; Results: exercise ability, quality of life, lung function and cardiopulmonary endurance. Two reviewers independently screen the title, abstract and full text. Finally, quality evaluation and meta-analysis were conducted.

Results:
In this study, 13 randomized controlled studies from 1468 articles were selected. A total of 456 patients with PF were enrolled. Compared with usual care in the control group, the 6-minute walking distance, predicted forced vital capacity, predicted forced expiratory volume at 1 second and maximal rate of oxygen consumption were increased significantly after exercise training, while there was no significant change in quality of life and predicted diffusing capacity of the lung for carbon monoxide.

Conclusion:
Exercise training can significantly improve the exercise capacity, lung function and cardiopulmonary endurance of patients with PF, but has no effect on the quality of life. Exercise training is an effective rehabilitation strategy for PF.
Endoscopic treatment for duodenal perforation due to biliary stent dislocation: A case report and brief review of the literature
Authors: Fujii Yuki , Matsumoto Kazuyuki , Miyamoto Kazuya , Matsumi Akihiro , Morimoto Kosaku , Terasawa Hiroyuki , Yamazaki Tatsuhiro , Horiguchi Shigeru , Tsutsumi Koichiro , Kato Hironari 
Published: December 2022

Rationale:Duodenal wall perforation by a dislocated biliary stent placed for biliary structure is rare but can be life-threatening. There are few reports on the management of stent-related duodenal perforation.Patient concerns:Three cases included in this study had undergone endoscopic retrograde cholangiopancreatography with placement of a plastic stent for biliary stricture. Two cases had symptoms (fever or abdominal pain), while other case showed no symptom after biliary stent placement.Diagnoses:Dislocation of plastic stents was revealed on computed tomography or endoscopic images. Two patients were diagnosed with duodenal perforation due to distal migration of long stents with a straight shape on the distal side. One patient was diagnosed with fistula formation between the intrahepatic bile duct and duodenum due to perforation of a pigtail stent.Interventions:All cases could successfully be managed endoscopically with closure by hemoclips or stent replacement.Outcomes:All 3 cases were improved after endoscopic treatment without any subsequent intervention.Lessons:Longer stents with a straight distal side are associated with a higher risk of duodenal perforation. Endoscopic management is appropriate as a first-line approach for a clinically stable patient. At the time of stent placement, we should pay attention to the length and type of stent.
Comparison of ultrasound with computed tomography to measure skeletal muscle mass in critically ill patients: A prospective study protocol
Authors: Peres Leandro Moreira , Luis-Silva Fabio , Menegueti Mayra Gonçalves , Sato Lucas , Basile-Filho Anibal , Suen Vivian Marques Miguel , Martins-Filho Olindo Assis , Auxiliadora-Martins Maria 
Published: December 2022

Introduction:
Therapy and nutritional status directly interfere in the clinical evolution of critically ill patients, in reducing morbidity and mortality, by maintaining the functional integrity of the gastrointestinal tract, decreasing the catabolic response, besides contributing to the reduction of hospitalization time resulting in less treatment cost. Critical patients and trauma victims suffer early changes in the quantity and quality of muscle mass. Tools to identify the groups most susceptible to these complications are necessary so that interventions can minimize the deleterious effects of malnutrition in critically ill patients.

Methods and analysis:
The aim of the present study is to measure muscle mass loss by measuring the thickness of the rectus femoris muscle by bedside ultrasound in critically ill patients admitted to the Intensive Care Unit (ICU) of a university hospital. Information will be collected regarding the length of hospital and ICU stay, the reason for admission, anthropometric data at admission and during hospitalization, energy needs, nutritional therapy used, and fasting time. This is a prospective, observational study that will be carried out in a single center in an ICU of a tertiary university hospital. The study population will undergo 3 tomographic images and 3 ultrasounds of the rectus femoris of each patient at different times. We propose, unprecedentedly, performing a validation study of ultrasound with the gold standard Computed tomography to evaluate the musculature of critically ill patients victims of traumatic brain injury. The results got will texto be fundamental for the development of new fields of investigation and certainly contribute to the discovery of a new approach to treat sarcopenia in critically ill patients. The Research Ethics Committee approved the study and all patients included will sign an informed consent form. (Clinical Record: RBR-2bzspnz).
Pembrolizumab versus paclitaxel for previously treated, advanced gastro-esophageal junction cancer: A systematic review and meta-analysis of randomized clinical trials
Authors: Swed Sarya , Shaheen Nour , Hafez Wael , Elsayed Talat Nesreen , Rozan Samah S. , Diab Rehab , Nashwan Abdulqadir J. , Motawea Karam R. , Alibrahim Hidar , Albuni Mhd Kutaiba , Battikh Elias , Sawaf Bisher , Shoib Sheikh 
Published: December 2022

Background:
This paper aims to compare the effectiveness and safety of pembrolizumab and paclitaxel as a second line for patients with locally advanced gastroesophageal cancer.

Methods:
By searching PubMed, Scopus, Web of Science, and Ovid, any randomized clinical study comparing the effectiveness of paclitaxel and pembrolizumab as second-line therapy for advanced gastroesophageal cancer met the inclusion criteria. Only 3 of the 23 eligible studies that were fully reviewed were eligible for meta-analysis.

Results:
The total number of patients included in the meta-analysis was 635 in the pembrolizumab group and 596 in the paclitaxel group. In terms of objective response rate, there was no statistically significant difference between pembrolizumab and paclitaxel (relative risk = 1.10, 95% CI = 0.80–1.50, P = .57). Furthermore, Pembrolizumab and paclitaxel did not differ in terms of the rate of partial response statistically significantly from one another, according to the overall analysis (relative risk = 0.93, 95% CI = 0.57–1.52, P-value = .78).

Conclusion:
There is no difference between pembrolizumab and paclitaxel in objective response rate. The objective response rate shows that doctors may consider either treatment for patients with advanced gastroesophageal cancer, given the time to response is comparable across therapies.
Association of low-density lipoprotein cholesterol levels with the risk of mortality and cardiovascular events: A meta-analysis of cohort studies with 1,232,694 participants
Authors: Peng Ke , Li Xingyue , Wang Zhen , Li Meiling , Yang Yongjian 
Published: December 2022

Background:
Lowering elevated low-density lipoprotein cholesterol (LDL-C) is an important strategy to prevent cardiovascular disease (CVD), while some studies report low LDL-C increases all-cause mortality. Our study aimed to explore the appropriate low LDL-C level with the lower CVD risk but with no excess risk for all-cause mortality.

Methods:
PubMed, Embase, Cochrane Library, and Web of Science were searched until April 7, 2021. Twenty cohort studies with 1232,694 adults were obtained. Effect size index was evaluated using pooled relative risk (RR) with 95% confidence interval (CI). Heterogeneity was assessed using the Cochran’s Q test and I
2 statistic, and heterogeneity sources was investigated using meta-regression. Publication bias was assessed and sensitivity analysis was performed.

Results:
The risks of all-cause mortality (RR: 1.34, 95%CI: 1.00–1.80), CVD death (RR: 1.79, 95%CI: 1.26–2.54), CHD death (RR: 2.03, 95%CI: 1.36–3.03) were higher in LDL-C ≥ 160 mg/dL than LDL-C of 70–129 mg/dL. Both LDL-C of 130–159 mg/dL and ≥ 160 mg/dL were associated with higher CVD risk than LDL-C of 70–129 mg/dL, with RR of 1.26 (95%CI: 1.08–1.47) and 1.70 (95%CI: 1.35–2.14), respectively. Compared to LDL-C of 70–129 mg/dL, no association was found between LDL < 70 mg/dL and all-cause mortality and CVD events.

Conclusion:
Our results found LDL-C ≥ 130 mg/dL was associated with the higher risk of all-cause mortality and CVD risk, indicating that adults with high LDL-C should take interventions to regulate the LDL-C level lower than 130 mg/dL.
Effectiveness and safety of Baduanjin for schizophrenia: A protocol for systematic review and meta-analysis
Authors: Wu Haiyuan , Xue Kaiyuan , Peng Aineng , Chai Jianbo , Zhao Yonghou 
Published: December 2022

Background:
The cause of schizophrenia is still unknown, the course of the disease is long and its onset is thought to be related to neurodevelopmental, genetic, and oxidative stress factors and so on. There is no means of cure. Typical drug therapy is effective in treating the acute stage of schizophrenia, while the impaired social and life functions of patients are often neglected. Baduanjin is a traditional Chinese physical and breathing exercise that not only strengthens the muscles, and moves the joints, but also exercises the will. Many studies have been reported in the study on the application of Baduanjin to schizophrenic patients to promote recovery, but no research systematically evaluates the therapeutic effects and safety of Baduanjin for schizophrenic patients. This study aims to systematically investigate the efficacy and safety of Baduanjin in the treatment of schizophrenic patients.

Methods:
Reports of randomized controlled trials (RCTs) on Baduanjin for schizophrenia will be searched in the following data sources, including 3 English databases（PubMed, EMBASE, Cochrane Library）and 4 Chinese databases（China National Knowledge Infrastructure, Chinese Biomedical Literature, Wanfang, and China Clinical Trials Registry Database）, and their publication time is restricted from the establishment of the database to October 1, 2022. Two reviewers will independently perform study selection, data extraction, and quality assessment. RevMan V.5.4 software will be used for meta-analysis. The protocol will be performed according to preferred reporting items for systematic reviews and meta-analysis protocols (PRISMA-P) guidelines.

Results:
The results will provide a systematic overview of the current evidence on the use of Baduanjin to treat schizophrenia.

Conclusion:
The conclusions of this study will help clarify whether Baduanjin is effective and safe for treating schizophrenia.
An effect comparison of alendronate and teriparatide in patients with glucocorticoid-induced osteoporosis: A protocol for systematic review and meta-analysis
Authors: Liang Na , Zhang Shuang , Wang Shuang , Ma Juan 
Published: December 2022

Background:
Glucocorticoid-induced osteoporosis is the most common secondary cause of osteoporosis and the resulting fractures cause significant morbidity. Oral bisphosphonates are currently regarded as first line options on the grounds of their low cost. However, teriparatide has been shown to be superior in its effects on bone mineral density and vertebral fracture risk in glucocorticoid-treated individuals with osteoporosis. We conducted a protocol for systematic review and meta-analysis to assess the effectiveness of alendronate and teriparatide in patients with glucocorticoid-induced osteoporosis.

Methods:
The study protocol has been registered on international prospective register of systematic review (PROSPERO registration number: CRD42022371561). The procedure of this protocol will be conducted according to the Preferred Reporting Item for Systematic Review and Meta-analysis Protocols guidance. PubMed, EMBASE, MEDLINE, the Cochrane Library, Chinese National Knowledge Infrastructure, Chinese Biomedical Literature Database, Wanfang Database, ClinicalTrials.gov trials registry, and Chinese Clinical Trial Registry will be searched from January 1980 to November 2022. Two authors will assess methodological quality of included studies separately by the Cochrane collaboration’s risk of bias tool. We will apply RevMan 5.4 software for statistical analysis.

Results:
This study will provide a high-quality comprehensive evaluation of the efficacy and safety of alendronate and teriparatide for treating patients with glucocorticoid-induced osteoporosis.

Conclusion:
The conclusion of our systematic review will provide evidence to judge whether teriparatide is an effective intervention for patients with glucocorticoid-induced osteoporosis.
Effects of educational music training on music performance anxiety and stress response among first-year undergraduate music education students
Authors: Nwokenna Edith N. , Sewagegn Abatihun Alehegn , Falade Temitope Ayodeji 
Published: December 2022

Background:
The effectiveness of educational music training in lowering stress and performance anxiety among first-year undergraduate music education students is an understudied area. The goal of this study was to determine if educational music training affects first-year undergraduate music education students’ stress and anxiety associated with musical performance.

Methods:
A randomized controlled trial design was used in this study. A waiting list group of 35 students and an educational music training intervention group of 35 first-year undergraduate music education students were randomized for the study to commence. The Kenny music performance anxiety (MPA) scale and perceived stress scale (PSS) were used as outcome measures.

Results:
The findings show that, among first-year undergraduate music education students, educational music training decreased their stress level associated with music performance [F(1, 68) = 390.751; P = .001, ηp
2 = 0.270]. It was also found that after the educational music training, the students reported decreased anxiety level associated with music performance [F(1, 68) = 1375.495; P = .001, ηp
2 = 0.344]. Significant interaction effects of educational music training and time on students’ stress [F(2, 68) = 127.301; P = .001] and anxiety levels [F(2, 68) = 260.535; P = .001] were also found.

Conclusion:
Educational music intervention can be successful as a means of reducing anxiety and stress in undergraduate music education students during the first year of study.
Evaluation of the effect of the COVID-19 pandemic on mucormycosis studies with bibliometric analysis
Authors: Arslan Gulen Tugba , Turunc Tuba , Sahin Ahmet Riza , Oruc Ebru , Kurutkan Mehmet Nurullah 
Published: December 2022

Background:
Coronavirus disease 2019 (COVID-19)-associated mucormycosis (CAM) is a relatively new concept in the literature that emerged during the pandemic. Bibliometric analysis is a type of analysis that uses mathematical and statistical methods to study the formal properties of knowledge areas. This study aimed to reveal the main themes, conceptual structures, and trends of bibliometric studies on mucormycosis in 2 different periods, pre-and during the pandemic.

Methods:
This study consisted of 2 periods: pre-COVID-19 and COVID-19. Articles were collected from the Web of Science (WOS) Core Collection database. We provided AND and OR connectors for the keyword query and selected studies based on relevant keywords. Collected data were classified based on their publication date and examined using the R programming language (Version 4.0.3) package Bibliometrix and SciMAT Software.

Results:
A total of 1261 articles were investigated, and performance and information structure analyses were conducted. Based on Bradford’s law, the Journal of Fungi was the top-ranked journal in both periods. Cureus and mycoses were placed 2nd and 3rd in the second period. India is the largest contributor. In performance analysis, conceptual structures such as Rhizopus oryzae, epidemiology, diagnosis, management, treatment, and outcomes were at the forefront of mucormycosis publications during the COVID-19 period.

Conclusions:
Research trends have shifted to the clinical treatment and management of COVID-19. Therefore, pathogenesis, diagnosis, follow-up, and treatment strategies for CAM should be developed in the future.