bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact on mental health and wellbeing in Indigenous communities due to land loss resulting from industrial resource development: protocol for a systematic review
Authors: Burns Nicole , Linton Janice , Pollock Nathaniel J. , Brubacher Laura Jane , Green Nadia , Keeling Arn , Latta Alex , Martin Jessica , Rand Jenny , Morton Ninomiya Melody E. 
Published: July 2022

AbstractBackgroundIndigenous Peoples are impacted by industrial resource development that takes place on, or near, their communities. Existing literature on impacts of industrial resource development on Indigenous Peoples primarily focus on physical health outcomes and rarely focus on the mental health impacts. To understand the full range of long-term and anticipated health impacts of industrial resource development on Indigenous communities, mental health impacts must be examined. It is well-established that there is a connection between the environment and Indigenous wellbeing, across interrelated dimensions of mental, physical, emotional, and spiritual health.MethodsThis paper identifies how the Community Advisory Team and a team of Indigenous and settler scholars will conduct the review. The literature search will use the OVID interface to search Medline, Embase, PsycINFO, and Global Health databases. Non-indexed peer-reviewed journals related to Indigenous health or research will be scanned. Books and book chapters will be identified in the Scopus and PsycINFO databases. The grey literature search will also include Google and be limited to reports published by government, academic, and non-profit organizations. Reference lists of key publications will be checked for additional relevant publications, including theses, dissertations, reports, and other articles not retrieved in the online searches. Additional sources may be recommended by team members. Included documents will focus on Indigenous Peoples in North America, South America, Australia, Aotearoa New Zealand, and Circumpolar regions, research that reports on mental health, and research that is based on land loss connected to dams, mines, agriculture, or petroleum development. Literature that meets the inclusion criteria will be screened at the title/abstract and full-text stages by two team members in Covidence. The included literature will be rated with a quality appraisal tool and information will be extracted by two team members; a consensus of information will be reached and be submitted for analysis.DiscussionThe synthesized evidence from this review is relevant for land use policy, health impact assessments, economic development, mental health service planning, and communities engaging in development projects.Systematic review registrationRegistered in the International Prospective Register of Systematic Reviews (PROSPERO; Registration numberCRD42021253720)
Categorizing distributed wind energy installations in the United States to inform research and stakeholder priorities
Authors: Preziuso Danielle , Orrell Alice , Lantz Eric 
Published: July 2022

Abstract
Background
Distributed wind energy adoption in the United States can contribute to the diverse portfolio of energy technologies needed to achieve ambitious decarbonization goals. However, with limited deployment to date, the current distributed wind market must be better understood; these efforts will support the range of stakeholders who will drive successful deployment. This article first distinguishes three categories of distributed wind from existing literature: (1) behind the meter, (2) intended for explicit local load, and (3) physically distributed. A novel methodology to classify individual wind installations into each of these categories is then presented and applied to two data sets of wind installations in the United States to categorize and illuminate distinct segments in the distributed wind market.

Results
Physically distributed installations, constituted by small to moderately sized projects serving local loads on distribution systems solely because of their proximity to them, account for the highest amount of capacity but the lowest number of installations out of the three categories. The inverse is true for behind-the-meter installations, which are used to serve on-site loads. Installations intended for explicit local load, which are interconnected on the utility side of the distribution system and intentionally built to provide energy to loads on the same distribution system, rank in the middle for both installed capacity and number of installations.

Conclusions
Distributed wind energy deployment in the United States is geographically widespread, but the extent to which a single category is developed in each state varies. Policies, wind resources, and broad energy technology trends contribute to these deployment patterns. By identifying the extent to which each category of installations exists, decision-makers are empowered with data necessary to tailor research and development programs and address stakeholder priorities through policy and other means, ultimately supporting future deployment.
Structure and specialization of mycorrhizal networks in phylogenetically diverse tropical communities
Authors: Perez-Lamarque Benoît , Petrolli Rémi , Strullu-Derrien Christine , Strasberg Dominique , Morlon Hélène , Selosse Marc-André , Martos Florent 
Published: July 2022

Abstract
Background
The root mycobiome plays a fundamental role in plant nutrition and protection against biotic and abiotic stresses. In temperate forests or meadows dominated by angiosperms, the numerous fungi involved in root symbioses are often shared between neighboring plants, thus forming complex plant-fungus interaction networks of weak specialization. Whether this weak specialization also holds in rich tropical communities with more phylogenetically diverse sets of plant lineages remains unknown. We collected roots of 30 plant species in semi-natural tropical communities including angiosperms, ferns, and lycophytes, in three different habitat types on La Réunion island: a recent lava flow, a wet thicket, and an ericoid shrubland. We identified root-inhabiting fungi by sequencing both the 18S rRNA and the ITS2 variable regions. We assessed the diversity of mycorrhizal fungal taxa according to plant species and lineages, as well as the structure and specialization of the resulting plant-fungus networks.

Results
The 18S and ITS2 datasets are highly complementary at revealing the root mycobiota. According to 18S, Glomeromycotina colonize all plant groups in all habitats forming the least specialized interactions, resulting in nested network structures, while Mucoromycotina (Endogonales) are more abundant in the wetland and show higher specialization and modularity compared to the former. According to ITS2, mycorrhizal fungi of Ericaceae and Orchidaceae, namely Helotiales, Sebacinales, and Cantharellales, also colonize the roots of most plant lineages, confirming that they are frequent endophytes. While Helotiales and Sebacinales present intermediate levels of specialization, Cantharellales are more specialized and more sporadic in their interactions with plants, resulting in highly modular networks.

Conclusions
This study of the root mycobiome in tropical environments reinforces the idea that mycorrhizal fungal taxa are locally shared between co-occurring plants, including phylogenetically distant plants (e.g. lycophytes and angiosperms), where they may form functional mycorrhizae or establish endophytic colonization. Yet, we demonstrate that, irrespectively of the environmental variations, the level of specialization significantly varies according to the fungal lineages, probably reflecting the different evolutionary origins of these plant-fungus symbioses. Frequent fungal sharing between plants questions the roles of the different fungi in community functioning and highlights the importance of considering networks of interactions rather than isolated hosts.
Improving the health-related quality of life of adult Nigerians living with cancer and their family caregivers: intervention development
Authors: Gabriel Israel , Creedy Debra , McGuire Amanda , Coyne Elisabeth 
Published: July 2022

Abstract
Background
Evidence for the effectiveness of interventions aimed at improving the health-related quality of life of people living with cancer and/or family members is compelling. However, most interventional research has been conducted in high-income countries, and no intervention had been tested in low-income countries such as Nigeria. It is critical to design a culturally theory-based intervention in a resource-poor setting to address the needs and support coping strategies of cancer patients and their family caregivers.

Methods
Theory, evidence, and practical issues were considered. The Medical Research Council framework for developing and evaluating complex interventions and Behaviour Change Wheel provided the framework for intervention design. Findings generated by a needs assessment of adult Nigerians with cancer and their family caregivers and relevant theories (the Spirituality and the Supportive Care Framework for Cancer) informed content development.

Results
A theory-based, culturally tailored socio-spiritual intervention was developed to address the specific needs of adult Nigerians with cancer and their family caregivers. A 4-week intervention included strategies designed to improve social and spiritual support, information and health literacy, and health-related quality of life.

Conclusions
A systemic approach was used to conceptualise an evidence-based and theory-informed intervention tailored to address previously identified shortfalls in support available to adults living with cancer and their family caregivers, in Nigeria. If implemented and effective, such an intervention has the potential to improve the health-related quality of life of people living with cancer and their families in Nigeria.
Evaluation parameters for evidence-based practices for people with autism spectrum disorder: a narrative review of group and single-subject design studies
Authors: da Hora Cássia Leal , Sella Ana Carolina 
Published: July 2022

AbstractRecommendations for using evidence-based practices have become increasingly common in services for individuals diagnosed with autistic spectrum disorder (ASD). The aim of this study was to conduct a narrative literature review to identify differences and similarities in evidence-evaluation criteria for group and single-subject designs that empirically support interventions for people with ASD. Data sources used in this analysis were reports and articles elaborated by different clearinghouses (i.e., National Autism Center, National Professional Development Center, and the National Clearinghouse on Autism Evidence and Practice). The criteria for evaluating evidence, as defined by these documents, contained specific components or quality indicators for each type of study design. The different criteria for evaluating evidence and for classifying the interventions (once evidence was evaluated) were identified and described. This manuscript discusses the need for (a) expanding the analysis beyond the evidence identified by different researchers and organizations such as the clearinghouses, (b) proposing interventions that are based not only on scientific evidence but also on social validity — which is directed by client idiosyncrasies, and (c) attention to the fact that EBPs should not be seen as static information regarding interventions with empirical support: evidence-based practices are the result of constant analysis of the intervention implementation data added to professional training and client values and context. Some additional issues and the study limitations are also presented.
Advances in understanding the soil-borne viruses of wheat: from the laboratory bench to strategies for disease control in the field
Authors: Yang Jian , Liu Peng , Zhong Kaili , Ge Tida , Chen Lu , Hu Haichao , Zhang Tianye , Zhang Haoqing , Guo Jun , Sun Bingjian , Chen Jianping 
Published: July 2022

AbstractIn China, soil-borne viruses transmitted by the root parasite Polymyxa graminis have caused significant yield loss in winter wheat for many years. At present, it is believed that two main soil-borne RNA viruses, namely wheat yellow mosaic virus (WYMV) and Chinese wheat mosaic virus (CWMV) are responsible for such losses. The molecular characteristics and infection processes of these two viruses have been intensively investigated and described substantially in detail, following the complete sequencing of their respective genomes. In this review, we highlight our recent findings on the distribution of WYMV and CWMV in China, the associated crop damage, the biological functions of WYMV and CWMV proteins as well as the viral temperature sensitivities. We also describe the characteristics of the resistance genes and discuss the novel virus–plant arms race strategies in hope of enlarging our understanding on the theme of virus-plant interactions. Finally, we compare current disease-management options and suggest the application of biotechnology-based genetic resistance to develop more cost-effective countermeasures for controlling soil-borne virus diseases in the future.
CTNNB1 polymorphism (rs121913407) in circulating tumor DNA (ctDNA) in Egyptian hepatocellular carcinoma patients
Authors: Abdel-Wahed Marwa A. , Amer Eman Mohamed Abdel Rahman , Mahmoud Ramy Mohamed , Montasser Iman Fawzy , Massoud Yassmin M. , Hamdy Perihan , Hassan Safeya Hamdy Zakaria 
Published: July 2022

Abstract
Background
Hepatocellular carcinoma (HCC) represents the sixth most common cancer worldwide and the fourth in Egypt. Persistent inflammation and specific somatic mutations in driving genes play a major role in the development of HCC. One of these somatic mutations is CTNNB1 mutations with subsequent activation of β-catenin in HCC, associated with a risk of malignant transformation. In this study, we investigate the clinical utility of peripheral blood circulating tumor DNA (ctDNA) CTNNB1 (rs121913407) in HCC patients compared to pathological chronic hepatitis C virus (HCV) patients and healthy controls.

Methods
Our study is a case-control study at the Ain Shams Centre for Organ Transplantation, Ain Shams University Hospitals, enrolling twenty-eight adult HCC patients (twelve early HCC patients and sixteen advanced HCC patients), ten patients with chronic hepatitis C as a disease control group, and ten healthy controls. We collected plasma and stored at −80 °C. We detected mutations in the gene locus CTNNB1 rs121913407 by real-time PCR.

Results
All of our studied cases (early and advanced HCC) in addition to HCV and healthy control groups were CTNNB1 wild (TT) genotype. There was statistical significant difference between early and late cases of HCC as regards AFP and AST.

Conclusions
None of our recruited subjects showed CTNNB1 rs121913407 gene mutation. Further studies on larger number of patients are needed to clarify and confirm the clinical utility of CTNNB1 single-nucleotide polymorphism in the pathogenesis of HCC related to HCV in Egyptian population.
CRISPR-Cas systems target endogenous genes to impact bacterial physiology and alter mammalian immune responses
Authors: Wu Qun , Cui Luqing , Liu Yingying , Li Rongpeng , Dai Menghong , Xia Zhenwei , Wu Min 
Published: July 2022

AbstractCRISPR-Cas systems are an immune defense mechanism that is widespread in archaea and bacteria against invasive phages or foreign genetic elements. In the last decade, CRISPR-Cas systems have been a leading gene-editing tool for agriculture (plant engineering), biotechnology, and human health (e.g., diagnosis and treatment of cancers and genetic diseases), benefitted from unprecedented discoveries of basic bacterial research. However, the functional complexity of CRISPR systems is far beyond the original scope of immune defense. CRISPR-Cas systems are implicated in influencing the expression of physiology and virulence genes and subsequently altering the formation of bacterial biofilm, drug resistance, invasive potency as well as bacterial own physiological characteristics. Moreover, increasing evidence supports that bacterial CRISPR-Cas systems might intriguingly influence mammalian immune responses through targeting endogenous genes, especially those relating to virulence; however, unfortunately, their underlying mechanisms are largely unclear. Nevertheless, the interaction between bacterial CRISPR-Cas systems and eukaryotic cells is complex with numerous mysteries that necessitate further investigation efforts. Here, we summarize the non-canonical functions of CRISPR-Cas that potentially impact bacterial physiology, pathogenicity, antimicrobial resistance, and thereby altering the courses of mammalian immune responses.
Real-world effectiveness of aripiprazole once-monthly REACT study: Pooled analysis of two noninterventional studies
Authors: Schöttle Daniel , Clerzius Guerline , Janetzky Wolfgang , Oluboka Oloruntoba , Roy Marc-André , Therrien François , Wiedemann Klaus 
Published: July 2022

AbstractBackgroundNoninterventional naturalistic studies are an important complement to randomized controlled trials. Aripiprazole once-monthly (AOM) is an atypical antipsychotic in a long-acting injectable formulation.MethodsA pooled analysis of two noninterventional studies was undertaken to validate previous results on AOM effectiveness and safety in a larger population and improve statistical power for preplanned subgroup analyses. We analyzed data from 409 patients with schizophrenia who were treated with AOM and were enrolled in noninterventional studies in Germany (via noninterventional studies registry 15,960 N) and Canada (NCT02131415). Data collected at baseline, 3 and 6 months were analyzed. Among the endpoints were psychopathology (brief psychiatric rating scale [BPRS]) and disease severity (clinical global impression [CGI]).ResultsMean patient age was 38.9 (SD 14.8) years, and 59.9% were male. BPRS decreased from 48.1 (SD 15.6) at baseline to 36.5 (SD 13.7) at month 6 (p < 0.001). CGI decreased from 4.47 (SD 0.90) at baseline to 3.64 (SD 1.16) at month 6 (p < 0.001). A total of 54.4% were responders (at least 20% reduction) on the BPRS, and 56.5% had a CGI-S-score that was at least 1 level better than baseline. A total of 43.4% were considered responders on both the BPRS and CGI scales. A total of 45.2% were considered in remission. Adverse events were rare and corresponded to the previously known safety profile of AOM.ConclusionsTreatment with AOM for patients with schizophrenia appeared effective and safe under real-life conditions.
Effectiveness of Intensive Versus Minimalist Follow-Up Regimen on Survival in Patients With Endometrial Cancer (TOTEM Study): A Randomized, Pragmatic, Parallel Group, Multicenter Trial
Authors: Zola Paolo , Ciccone Giovannino , Piovano Elisa , Fuso Luca , Di Cuonzo Daniela , Castiglione Anna , Pagano Eva , Peirano Elena , Landoni Fabio , Sartori Enrico , Narducci Fabrice , Bertetto Oscar , Ferrero Annamaria ,   the TOTEM Collaborative Group
Published: July 2022

PURPOSE In the absence of clear evidence from randomized trials, the intensity of follow-up regimens after surgical treatment of endometrial cancer is highly variable in clinical practice. To reduce this uncertainty, we conducted a randomized trial to test whether an intensive (INT) versus a minimalist (MIN) follow-up regimen improves overall survival (OS) in patients undergoing operation for endometrial cancer. METHODS The TOTEM study was a large, pragmatic randomized trial, conducted in 42 hospitals (in Italy and France) including patients surgically treated for endometrial cancer, in complete clinical remission, International Federation of Gynecology and Obstetrics stage I-IV. After stratification by center and risk of relapse (low or high), patients were randomly assigned (1:1) to INT or MIN hospital-based follow-up regimens. The study was powered to demonstrate an absolute improvement of 5% of the 5-year OS with the INT regimen. RESULTS In total, 1,871 patients were randomly assigned between November 2008 and July 2018, and 1,847 patients (98.7%) were available for the final analysis (60% low risk). After a median follow-up of 69 months, the 5-year OS was 90.6% in the INT and 91.9% in the MIN arms (hazard ratio, 1.13, 95% CI, 0.86 to 1.50, P = .380). No differences in OS were found in subgroup analyses considering age, cancer treatment, risk of relapse, and degree of adherence of the center to the scheduled follow-up. The probability of detecting a relapse was slightly higher in the INT arm (hazard ratio, 1.17; 95% CI, 0.92 to 1.48; P = .194). CONCLUSION An INT follow-up in endometrial cancer–treated patients does not improve OS, even in high-risk patients. According to available evidence, there is no need to routinely add vaginal cytology, laboratory, or imaging investigations to the MIN regimens used in this trial.
Dissimilarity-based filtering and compression of complex weighted networks
Authors: Jiang Yuanxiang , Li Meng , Di Zengru 
Published: July 2022

Abstract
As a classical problem, network filtering or compression, obtaining a subgraph by removing certain nodes and edges in the network, has great significance in revealing the important information under the complex network. Some present filtering approaches adopting local properties usually use limited or incomplete network information, resulting in missing or underestimating a lot of information in the network. In this paper, we propose a new network filtering and compression algorithm based on network similarity. This algorithm aims at finding a subnetwork with the minimum dissimilarity from the original one. In the meantime, it will retain comprehensively structural and functional information of the original network as much as possible. In detail, we use a simulated annealing algorithm to find an optimal solution of the above minimum problem. Compared with several existing network filtering algorithms on synthetic and real-world networks, the results show that our method can retain the properties better, especially on distance-dependent attributes and network with stronger heterogeneity.