bluuebunny/crossref_metadata_2025_split huggingface dataset:
The utility of cfDNA in TGCT patient management: a systematic review
Authors: Krasic Jure , Skara Lucija , Bojanac Ana Katusic , Ulamec Monika , Jezek Davor , Kulis Tomislav , Sincic Nino 
Published: May 2022

Background: Testicular germ cell tumors (TGCTs) are the most common young male malignancy with a steadily rising incidence. Standard clinical practice is radical orchidectomy of suspicious lumps followed by histopathological diagnosis and tumor subtyping. This practice can lead to complications and quality of life issues for the patients. Liquid biopsies, especially cell-free DNA (cfDNA), promised to be true surrogates for tissue biopsies, which are considered dangerous to perform in cases of testicular tumors. In this study, we have performed a systematic review on the potential of cfDNA in TGCT patient management, its potential challenges in translation to clinical application and possible approaches in further research. Materials & Methods: The review was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines on EuropePMC and PUBMED electronic databases, with the last update being on October 21, 2021. Due to the high heterogeneity in identified research articles, we have performed an overview of their efficacy. Results: Eight original articles have been identified on cfDNA in TGCT patients published from 2004 to 2021, of which six had more than one TGCT patient enrolled and were included in the final analysis. Three studies investigated cfDNA methylation, one has investigated mutations in cfDNA, two have investigated cfDNA amount, and one has investigated cfDNA integrity in TGCT. The sensitivity of cfDNA for TGCT was found to be higher than in serum tumor markers and lower than miR-371a-3p, with comparable specificity. cfDNA methylation analysis has managed to accurately detect teratoma in TGCT patients. Conclusion: Potential challenges in cfDNA application to TGCT patient management were identified. The challenges relating to the biology of TGCT with its low mutational burden and low cfDNA amounts in blood plasma make next-generation sequencing (NGS) methods especially challenging. We have also proposed possible approaches to help find clinical application, including a focus on cfDNA methylation analysis, and potentially solving the challenge of teratoma detection.
Toward a digital decision- and workflow-support system for initiation and control of long-term non-invasive ventilation in stable hypercapnic COPD patients
Authors: Cornelissen Christian Gabriel , Winter Stefan , Keuchel Daniel , Spicher Nicolai , Boeckmann Britta , Stephan Christian , Saygi Tan , Windisch Wolfram , Vollmer Thomas , Dreher Michael 
Published: May 2022

Introduction: Due to an increasing demand for the initiation and control of non-invasive ventilation (NIV), digital algorithms are suggested to support therapeutic decisions and workflows in an ambulatory setting. The DIGIVENT project established and implemented such algorithms for patients with chronic hypercapnic respiratory failure due to chronic obstructive pulmonary disease (COPD) by a predefined process. Methods: Based on long-term clinical experience and guideline recommendations as provided by the German Respiratory Society, detailed graphical descriptions of how to perform NIV in stable COPD patients were created. Subsequently, these clinical workflows were implemented in the Business Process Model and Notation (BPMN) as one tool to formalize these workflows serving as input for an executable digital implementation. Results: We succeeded in creating an executable digital implementation that reflects clinical decision-making and workflows in digital algorithms. Furthermore, we built a user-friendly graphical interface that allows easy interaction with the DIGIVENT support algorithms. Conclusion: The DIGIVENT project established digital treatment algorithms and implemented a decision- and workflow-support system for NIV whose validation in a clinical cohort is planned.
Exploring the experiences of people and family carers from under-represented groups in self-managing Parkinson's disease and their use of digital health to do this
Authors: Nimmons Danielle , Armstrong Megan , Pigott Jennifer , Walters Kate , Schrag Anette , Ogunleye Della , Dowridge Wesley , Read Joy , Davies Nathan 
Published: May 2022

Introduction Digital health is thought to enable people to better manage chronic conditions, such as Parkinson's. However, little is known about how people from under-represented groups with chronic conditions use digital health to self-manage. Objective The objective of our study was to explore the experiences of people and family carers from under-represented groups in self-managing Parkinson's, including their use of digital health to do this. Methods Semi-structured interviews (n = 18, including four dyadic) were conducted remotely, with 16 people with Parkinson's and six family carers in 2020–2021. Participants were purposively sampled from under-represented groups: belong to an ethnic minority, or having significant physical or sensory impairment. Interviews were audio-recorded, transcribed and analysed using thematic analysis. Results Three main themes of importance were developed: ‘self-management support’, ‘digital health use to support self-management’ and ‘identity, attitudes and characteristics’. Participants received medical, psychological, social and practical self-management support. Some participants used digital health resources, e.g., Parkinson's UK website. Digital literacy was the biggest barrier to using digital health, regardless of background, often dependant on previous occupation and confidence. Few ethnic minority participants thought race or culture alters self-management ability and most believed there was no need for digital health interventions to be tailored to an individual's race or culture. Some felt inclusivity was important in terms of diverse images of people. A range of considerations were identified to optimise digital health, such as assistive equipment for people with sensory impairment. Conclusions Barriers to using digital health for self-management were primarily dependent on personal factors including digital literacy and attitudes but rarely race or culture. We recommend the optimisation of digital health interventions by providing assistive technology at low cost, and visual inclusiveness should be promoted by including images of people from diverse backgrounds.
Towards a multi-user experience approach to exploring key requirements to design smart habilitation devices for children with cerebral palsy
Authors: Bonello Matthew , Farrugia Philip , Buhagiar Nathalie , Mercieca Joseph 
Published: May 2022

Introduction This paper takes a multi-stakeholder approach to generate key requirements to design smart habilitation devices for children with Cerebral Palsy. Four groups of different relevant stakeholders of smart-habilitation devices were approached to participate in this study, including children with Cerebral Palsy, their parents, occupational therapists, as well as technical specialists. Methods Profiles of children with Cerebral Palsy were generated to have a concrete idea of their needs and desires. Meanwhile, for the three stakeholders, focus groups were used to gather their insights and requirements on a prospective smart habilitation device for children. Successively, a thematic analysis was conducted to analyse the qualitative data obtained during the focus groups. Results Eight design requirements were developed to generate designs which stimulate high quality user experiences in children and other users of smart habilitation devices. In addition, an initial framework of the process that design engineers would follow to design such devices for children was proposed. Conclusion Adopting this framework, and the respective requirements, will help design engineers to implement a multi-user approach and amend the design according to stakeholders' goals and desires. The resulted design should ensure a high quality user experience for both the active and potential passive users of smart habilitation devices.
Examining the Impact of Corporate Social Responsibility on the Financial Performance of Indian Companies
Authors: Deb Dipanita , Gillet Philippe , Bernard Philippe , De Anupam 
Published: May 2022

Corporates play a vital role in the economy and are subject to growing expectations from stakeholders. Therefore, it is essential to understand the financial impact of corporate social responsibility (CSR) on corporates’ activities. This article examines the impact of CSR on 30 Bombay Stock Exchange (BSE)-listed corporate efficiencies by using multi-criteria decision-making models. The article emphasized the technical efficiency of 30 BSE-listed corporates and explored high-efficiency drivers. This study applies multiple methods, that is, data envelopment analysis and free disposal hull, to observe the efficiency rankings of the 30 BSE Index-listed companies for 6 years, that is, 2014–2020. In the second stage, we perform truncated regression analysis to validate our results on the association between CSR and the financial performance of the corporate. The findings suggest that 6 out of 30 corporates are technically efficient (TE = 1) in all frontier approaches. Furthermore, the outcomes portray those three pillars of CSR (i.e., environment, social and governance) are positively correlated with efficiency. Furthermore, it has also been observed that environment and social scores are positively related to return on assets. The findings can be helpful for the stakeholders, policymakers and management of the corporate as a guideline to implement CSR practices.
Assessment of Characteristics and Methodological Quality of the Top 50 Most Cited Articles on Platelet-Rich Plasma in Musculoskeletal Medicine
Authors: Bugarin Amador , Schroeder Grant , Shi Brendan Y. , Jones Kristofer J. , Kremen Thomas J. 
Published: May 2022

Background: The wide range of clinical applications and controversial scientific evidence associated with platelet-rich plasma (PRP) therapy in musculoskeletal medicine requires an examination of the most commonly cited studies within this field. Purpose: To identify the 50 most cited articles on PRP, assess their study design, and determine any correlations between the number of citations and level of evidence (LoE) or methodological quality. Study Design: Cross-sectional study. Methods: The Web of Science database was queried to identify the top 50 most cited articles on PRP in orthopaedic surgery. Bibliometric characteristics, number of citations, and LoE were recorded. Methodological quality was evaluated using the Modified Coleman Methodology Score (MCMS), Methodological Index for Non-randomized Studies (MINORS), and Minimum Information for Studies Evaluating Biologics in Orthopaedics (MIBO). The Pearson correlation coefficient and Spearman correlation coefficient ( r S) were used to determine the degree of correlation between the number of citations or citation density and LoE, MCMS, MINORS score, and MIBO score. Student t tests were performed for 2-group comparisons. Results: The top 50 articles were published between 2005 and 2016 in 21 journals. The mean number of citations and citation density were 241 ± 94 (range, 151-625) and 23 ± 8, respectively, and the mean LoE was 2.44 ± 1.67, with 15 studies classified as LoE 1. The mean MCMS, MINORS score, and MIBO score were 66.9 ± 12.6, 16 ± 4.7, and 12.4 ± 3.7, respectively. No correlation was observed between the number of citations or citation density and LoE, MCMS, MINORS score, and MIBO score. A significant difference ( P = .02) was noted in LoE in articles from the United States (3.56 ± 1.7) versus outside the United States (2 ± 1.5). Seven of the 8 in vivo studies were published between 2005 and 2010, whereas 19 of the 25 clinical outcome investigations were published between 2011 and 2016. Studies that were published more recently were found to significantly correlate with number of citations ( r S = –0.38; P = .01), citation density ( r S = 0.36; P = .01), and higher LoE ( r S = 0.47; P = .01). Conclusion: The top 50 most cited articles on PRP consisted of high LoE and fair methodological quality. There was a temporal shift in research from in vivo animal studies toward investigations focused on clinical outcomes.
Time, the other dimension of urban form: Measuring the relationship between urban density and accessibility to grocery shops in the 10-minute city
Authors: Kesarovski Todor , Hernández-Palacio Fabio 
Published: May 2022

Compact settlements take advantage of economies of scale by sustaining a system of high-quality socio-economic services at close proximities. Urban density with a balanced mix of uses also benefits walking and cycling as mobility modes that provide sufficient access to urban amenities, especially when combined with effective public transport. Indeed, walking and cycling can decrease the use of cars for short-distance trips. From this perspective, urban density can help to reduce pollution, optimise energy consumption and decrease infrastructural expenditures while contributing to more attractive urban environments. These ideas have induced a new wave of time geography planning concepts, such as the ‘10-minute city’, to enhance urban sustainability. For these concepts to move beyond visionary narratives, they must be expressed in specific empirical frameworks. Thus, the current research focuses on accessibility to grocery shops, as an essential urban service, in the Stavanger metropolitan area (Norway) using 10 minutes isochrones for walking and cycling. The study integrates open data, GIS network analyses, statistical regressions and bivariate representations of the results. The research estimates the level of serviceability by quantifying the number of shops that are accessible for each location and interrelates this estimation with spatial and population densities. The paper also presents a method to detect spatial inequalities by visualising over/under-serviced areas. This visualisation can become a tool to support strategies to rebalance such imbalances. Moreover, this study offers a practical approach towards the ‘10-minute city’ concept, as it can be adjusted to different isochrones at different spatial scales. In general, this approach can serve both to analyse existing contexts and to model strategies to support sustainability policies, such as urban densification and the promotion of environmental-friendly transport.
Allergen immunotherapy effectively reduces the risk of exacerbations and lower respiratory tract infections in both seasonal and perennial allergic asthma: a nationwide epidemiological study
Authors: Woehlk Christian , Von Bülow Anna , Ghanizada Muzhda , Søndergaard Marianne Baastrup , Hansen Susanne , Porsbjerg Celeste 
Published: May 2022

BackgroundAllergic asthma is associated with increased risk of respiratory tract infections and exacerbations. It remains unclear whether this susceptibility is conditioned by seasonal or by perennial allergy.AimTo investigate perennial allergy compared with seasonal allergy as a risk factor for lower respiratory tract infections and exacerbations in asthma and whether this risk can be reduced by allergen immunotherapy (AIT).MethodologyThis is a prospective register-based nationwide study of 18–44-year-olds treated with AIT during 1995–2014. Based on the type of AIT and use of anti-asthmatic drugs, patients were subdivided into two groups: perennial allergic asthma (PAA)versusseasonal allergic asthma (SAA). Data on antibiotics against lower respiratory tract infections (LRTI) and oral corticosteroids for exacerbations were analysed before starting AIT (baseline) and 3 years after completing AIT (follow-up).ResultsWe identified 2688 patients with asthma treated with AIT, of whom 1249 had PAA and 1439 had SAA. At baseline, patients with SAA had more exacerbations (23.8%versus16.5%, p≤0.001), but there were no differences in LRTI. During the 3-year follow-up, we observed a highly significant reduction of exacerbations with an average decrease of 57% in PAA and 74% in SAA. In addition, we observed a significant reduction of LRTI in both PAA and SAA: 17% and 20% decrease, respectively.ConclusionAIT effectively reduced the risk of exacerbations and lower respiratory tract infections in both seasonal and perennial allergic asthma. Perennial allergy is seemingly not a stronger risk factor for respiratory infections and exacerbations than seasonal allergy.
Relationship between biomarkers and findings on low-dose computed tomography in hospitalised patients with acute exacerbation of COPD
Authors: Prins Hendrik J. , Duijkers Ruud , Kramer Gerdien , Boerhout Els , Rietema Floris J. , de Jong Pim A. , Schoorl Marianne I. , van der Werf Tjip S. , Boersma Wim G. 
Published: May 2022

BackgroundAcute exacerbations of COPD (AECOPD) and community acquired pneumonia (CAP) often coexist. Although chest radiographs may differentiate between these diagnoses, chest radiography is known to underestimate the incidence of CAP in AECOPD. In this exploratory study, we prospectively investigated the incidence of infiltrative changes using low-dose computed tomography (LDCT). Additionally, we investigated whether clinical biomarkers of CAP differed between patients with and without infiltrative changes.MethodsPatients with AECOPD in which pneumonia was excluded using chest radiography underwent additional LDCT-thorax. The images were read independently by two radiologists; a third radiologist was consulted as adjudicator. C-reactive protein (CRP), procalcitonin (PCT), and serum amyloid A (SAA) at admission were assessed.ResultsOut of the 100 patients included, 24 had one or more radiographic abnormalities suggestive of pneumonia. The interobserver agreement between two readers (Cohen's κ) was 0.562 (95% CI 0.371–0.752; p<0.001). Biomarkers were elevated in the group with radiological abnormalities compared to the group without abnormalities. Median (interquartile range (IQR)) CRP was 76 (21.5–148.0) mg·L−1compared to 20.5 (8.8–81.5) mg·L−1(p=0.018); median (IQR) PCT was 0.09 (0.06–0.15) µg·L−1compared to 0.06 (0.04–0.08) μg·L−1(p=0.007); median (IQR) SAA was 95 (7–160) µg·mL−1compared to 16 (3–89) µg·mL−1(p=0.019). Sensitivity and specificity for all three biomarkers were moderate for detecting radiographic abnormalities by LDCT in this population. The area under the receiver operating characteristic curve was 0.66 (95% CI 0.52–0.80) for CRP, 0.66 (95% CI 0.53–0.80) for PCT and 0.69 (95% CI 0.57–0.81) for SAA.ConclusionLDCT can detect additional radiological abnormalities that may indicate acute-phase lung involvement in patients with AECOPD without infiltrate(s) on the chest radiograph. Despite CRP, PCT and SAA being significantly higher in the group with radiological abnormalities on LDCT, they proved unable to reliably detect or exclude CAP. Further research is warranted.
Characterization of erenumab and rimegepant on calcitonin gene-related peptide induced responses in Xenopus Laevis oocytes expressing the calcitonin gene-related peptide receptor and the amylin-1 receptor
Authors: Hage La Cour Sanne , Juhler Kiki , Kogelman Lisette J. A. , Olesen Jes , Klærke Dan Arne , Kristensen David Møbjerg , Jansen-Olesen Inger 
Published: May 2022

Abstract
Background
The clinical use of calcitonin gene-related peptide receptor (CGRP-R) antagonists and monoclonal antibodies against CGRP and CGRP-R has offered new treatment possibilities for migraine patients. CGRP activates both the CGRP-R and structurally related amylin 1 receptor (AMY1-R). The relative effect of erenumab and the small-molecule CGRP-R antagonist, rimegepant, towards the CGRP-R and AMY-R needs to be further characterized.

Methods
The effect of CGRP and two CGRP-R antagonists were examined in Xenopus laevis oocytes expressing human CGRP-R, human AMY1-R and their subunits.

Results
CGRP administered to receptor expressing oocytes induced a concentration-dependent increase in current with the order of potency CGRP-R> > AMY1-R > calcitonin receptor (CTR). There was no effect on single components of the CGRP-R; calcitonin receptor-like receptor and receptor activity-modifying protein 1. Amylin was only effective on AMY1-R and CTR. Inhibition potencies (pIC50 values) for erenumab on CGRP induced currents were 10.86 and 9.35 for CGRP-R and AMY1-R, respectively. Rimegepant inhibited CGRP induced currents with pIC50 values of 11.30 and 9.91 for CGRP-R and AMY1-R, respectively.

Conclusion
Our results demonstrate that erenumab and rimegepant are potent antagonists of CGRP-R and AMY1-R with 32- and 25-times preference for the CGRP-R over the AMY1-R, respectively. It is discussed if this difference in affinity between the two receptors is the likely reason why constipation is a common and serious adverse effect during CGRP-R antagonism but less so with CGRP binding antibodies.
Effect of berberine on global modulation of lncRNAs and mRNAs expression profiles in patients with stable coronary heart disease
Authors: Han Ye-Chen , Xie Hong-Zhi , Lu Bo , Xiang Ruo-Lan , Li Jing-Yi , Qian Hao , Zhang Shu-Yang 
Published: May 2022

AbstractBackgroundBerberine (BBR) is an isoquinoline alkaloid found in the Berberis species. It was found to have protected effects in cardiovascular diseases. Here, we investigated the effect the regulatory function of long noncoding RNAs (lncRNAs) during the treatment of stable coronary heart disease (CHD) using BBR. We performed microarray analyses to identify differentially expressed (DE) lncRNAs and mRNAs between whole blood samples from 5 patients with stable CHD taking BBR and 5 no BBR volunteers. DE lncRNAs and mRNAs were validated by quantitative real-time PCR.ResultsA total of 1703 DE lncRNAs and 912 DE mRNAs were identified. Kyoto Encyclopedia of Genes and Genomes pathway analysis indicated DE mRNAs might be associated with mammalian target of rapamycin and mitogen-activated protein kinase pathway. These pathways may be involved in the healing process after CHD. To study the relationship between mRNAs encoding transcription factors (DNA damage inducible transcript 3, sal-like protein 4 and estrogen receptor alpha gene) and CHD related de mRNAs, we performed protein and protein interaction analysis on their corresponding proteins. AKT and apoptosis pathway were significant enriched in protein and protein interaction network. BBR may affect downstream apoptosis pathways through DNA damage inducible transcript 3, sal-like protein 4 and estrogen receptor alpha gene. Growth arrest-specific transcript 5 might regulate CHD-related mRNAs through competing endogenous RNA mechanism and may be the downstream target gene regulated by BBR. Verified by the quantitative real-time PCR, we identified 8 DE lncRNAs that may relate to CHD. We performed coding and non-coding co-expression and competing endogenous RNA mechanism analysis of these 8 DE lncRNAs and CHD-related DE mRNA, and predicted their subcellular localization and N6-methyladenosine modification sites.ConclusionOur research found that BBR may affect mammalian target of rapamycin, mitogen-activated protein kinase, apoptosis pathway and growth arrest-specific transcript 5 in the process of CHD. These pathways may be involved in the healing process after CHD. Our research might provide novel insights for functional research of BBR.