bluuebunny/crossref_metadata_2025_split huggingface dataset:
Knowledge and practice of community pharmacists towards SGLT2 inhibitors
Authors: Alqudah Abdelrahim , Oqal Muna , Al-Samdi Ahmad , Qnais Esam , Wedyan Mohammed , Abu Gneam Majd , Alnajjar Roaa , Alajarmeh Manar , Yousef Elaf , Gammoh Omar 
Published: June 2022

Background: Sodium/glucose cotransporter 2 (SGLT2) inhibitors are a new class of oral anti-diabetic drugs which improve glycaemic control in type 2 diabetes mellitus (T2DM) by preventing the kidney from reabsorbing glucose back to blood. Community pharmacists have long-term relationships with most of their chronic patients, so they play a key role in care for people with diabetes. Therefore, the objective of this study was to assess pharmacists’ knowledge and practice towards SGLT2 inhibitors. Methods: A cross-sectional study was conducted to meet the study objectives. A convenience sample of 348 community pharmacists in Jordan was recruited. knowledge and practice were assessed using a self-administered questionnaire created for the purpose of this study. Results: A total of 400 community pharmacists were reached, of whom 348 answered the survey (response rate 87%). The results indicated that SGLT2 inhibitors knowledge score among community pharmacists in Jordan was 6.61 (out of 12). Factors like age, gender, location of the pharmacy, years of pharmacists’ experience had no effect on knowledge score; however, pharmacists who attended training courses on diabetes had higher knowledge scores. Additionally, pharmacists’ dispensing practice toward SGLT2 inhibitors had insufficient knowledge, such as lack of knowledge about the superiority of SGLT2 inhibitors over other anti-diabetics and inability to give the best advice to patients. Conclusions: Our findings reflect a moderate knowledge among community pharmacists about SGLT2 inhibitors which may negatively affect the patients’ outcome; thus, continuous education for the pharmacists is essential.
A computational biology approach for the identification of potential SARS-CoV-2 main protease inhibitors from natural essential oil compounds.
Authors: Hasib Rizone Al , Ali Md. Chayan , Rahman Md. Shahedur , Rahman Md. Mafizur , Ahmed Fee Faysal , Mashud Md. Abdullah Al , Islam Md. Azizul , Jamal Mohammad Abu Hena Mostofa 
Published: June 2022

Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has fomented a climate of fear worldwide due to its rapidly spreading nature, and high mortality rate. The World Health Organization declared it a global pandemic on 11 March 2020. Many endeavors have been made to find appropriate medications to restrain the SARS-CoV-2 infection from spreading but there is no specific antiviral therapy to date. However, a computer-aided drug design approach can be an alternative to identify probable drug candidates within a short time. SARS-CoV-2 main protease is a proven drug target, and it plays a pivotal role in viral replication and transcription. Methods: In this study, we identified a total of 114 essential oil compounds as a feasible anti-SARS-CoV-2 agent from several online reservoirs. These compounds were screened by incorporating absorption, distribution, metabolism, excretion, and toxicity (ADMET) profiling, molecular docking, and 50 ns of molecular dynamics simulation to identify potential drug candidates. The crystallized SARS-CoV-2 main protease structure was collected from the Research Collaboratory for Structural Bioinformatics Protein Data Bank database (Protein Data Bank ID 6LU7). Results: According to the results of the ADMET study, none of the compounds have any side effects that could reduce their druglikeness or pharmacokinetic properties. Among 114 compounds, we selected bisabololoxide B, eremanthin, and leptospermone as top drug candidates based on their higher binding affinity scores, and strong interaction with the Cys 145-His 41 catalytic dyad. Finally, the molecular dynamics simulation was implemented to evaluate the structural stability of the ligand-receptor complex. Molecular dynamics simulation disclosed that all the hits showed conformational stability compared to the positive control α-ketoamide. Conclusions: Our study showed that the top three hits might work as potential anti-SARS-CoV-2 agents, which can pave the way for discovering new drugs, but further in vivo trials will require for experimental validation.
COVID-19 Impact Sentiment Analysis on a Topic-based Level
Authors: Hankar Mustapha , Birjali Marouane , El-Ansari Anas , Beni-Hssane Abderrahim 
Published: June 2022

Last December 2019, health officials in Wuhan, a province from China, identified a novel coronavirus called SARS-CoV-2 causing pneumonia. In March 2020, World Health Organization (WHO) declared COVID-19 disease being a pandemic. During quarantine periods, people all over the globe were living under severe and overwhelming circumstances and expressing feelings of loneliness, dread, and anxiety. The pandemic has had a significant impact on the labor markets. As a result, several employees have lost their jobs while others are in grave danger to lose their positions the next day. In this paper, we developed a hybrid approach integrating sentiment analysis combined with topic modeling to analyze the impact of the COVID-19 pandemic on Moroccan citizens. The data used in this study includes comments collected from a well-known news website in Morocco called Hespress. Our approach follows a two-step process. In the first step, we implement a topic modeling method to analyze and extract topics from Arabic comments, and in the second step, we perform topic-based sentiment analysis to classify people’s feedback on extracted topics. The final results revealed that the expressed sentiments regarding all the topics are highly negative.
Short Communication: Metabolites of Albizia inhibit in vitro growth of phosphate solubilizing microbial consortia isolated from tea garden soil of Darjeeling hills, India
Authors: SAHA SUMEDHA , GHOSH ARINDAM , ACHARYYA SUKANYA , BHATTACHARYA MALAY 
Published: June 2022

Abstract. Saha S, Ghosh A, Acharyya S, Bhattacharya M. 2022. Short Communication: Metabolites of Albizia inhibit in vitro growth of phosphate solubilizing microbial consortia isolated from tea garden soil of Darjeeling hills, India. Biodiversitas 23: 2865-2870. Phosphate solubilizing microorganisms (PSM) play a crucial role in maintaining the nutritional status and fertility of the soil. PSMs help in solubilizing the metallic phosphate salts of soil into available phosphate anions for easy uptake by plants. However, this beneficial group of microorganisms also face different challenges for survival from its immediate surroundings. This study was carried out to assess the effect of shade tree litters on the PSM consortia isolated from different tea garden soils of Darjeeling hills, since shade trees are an integral part of tea plantations. Albizia odoratissima, Albizia chinensis and Albizia procera, widely used in tea gardens as shade trees were selected. GC-MS analysis was carried out to detect the metabolites produced by the litters. Twenty-three compounds exhibiting antimicrobial activities were detected. Major peak was found in A. odoratissima, followed by A. chinensisand least in A. procera. Compounds like 1-heptanol, 2-propyl-, neophytadiene, phytol and squalene were common in all three extracts and are considered to provided antimicrobial activity to Albizia. A proportional relation has been observed between magnitude of inhibition zones and peak area percentage in Albizia spp. PSM isolates from shade tree gardens were observed to be more tolerant toward the leaf extracts.
Yield evaluation of curly chili lines in three lowland locations
Authors: SYUKUR MUHAMAD , SAHID ZULFIKAR DAMARALAM , SOBIR SOBIR , MAHARIJAYA AWANG , RITONGA ARYA WIDURA , YUNANDRA YUNANDRA , SULASSIH SULASSIH , ISTIQLAL MUHAMMAD RIDHA ALFARABI , HAKIM ABDUL , WAHYU YUDIWANTI , VICENTE TOBIAS MONIZ , MUKHLISIN MUKHLISIN , AGUSTINA KARLIN , YURSIDA YURSIDA , MUSLIMIN KUNCI , HAFSAH SITI , NURA NURA , SETYAWAN ANDRY 
Published: June 2022

Abstract. Syukur M, Sahid ZD, Sobir, Maharijaya A, Ritonga AW, Yunandra, Sulassih, Istiqlal MRA, Hakim A, Wahyu Y, Vicente TM, Mukhlisin, Agustina K, Yursida, Muslimin K, Hafsah S, Nura, Setyawan A. 2022. Yield evaluation of curly chili lines in three lowland locations.Biodiversitas 23: 3219-3223. Yield evaluation of curly chili lines in three lowland locations. Increased consumption of spicy food is the latest trend in the 21st century. Curly chili as a type of chili that has a spiciness that is acceptable to the community is needed to meet consumer needs. This study aims to identify the growth, fruit, and yield components of several genotypes of curly chili. The study was conducted in multi-location at four planting sites. Each location used a randomized complete block design (RCBD) with three replications. Each replication used ten sample plants. Neno IPB as a chili variety produced by breeding has a faster flowering and harvesting time than all other genotypes. In addition, the productivity of Neno IPB was high and consistent in all cultivation locations. The results of the pheatmap analysis show that Neno IPB was one group with commercial varieties (Laris and Kastilo F1). A significant positive correlation based on Pearson's analysis was shown in the combination of flowering time-harvesting time, fruit length-fruit weight, and fruit weight per plant-total fruit per plant-productivity. However, flowering time-harvesting time-fruit weight per plant showed a significant negative correlation.
Yo, absoluto y libertad: perspectivas sobre la filosofía de Fichte
Authors: Gaudio Mariano Lucas 
Published: June 2022

Se trata de una reseña amplia y que reconstruye la estructura, el desarrollo y cada uno de los momentos del libro de J. Rivera de Rosales, Fichte. La libertad es el fundamento del conocimiento y de la moral, Barcelona, RBA, 2015, 159 páginas.
CFD Comparison of multiphase models in the pool boiling state
Authors: Enjadat Suleiman MJ. 
Published: June 2022

Abstract
With the development of simulation technology and programs, it became necessary to study the models that control equations’ solutions and influence the results. The models having control over solving equations of multiple phases and materials are investigated. They include (Volume of Fluid (VOF), mixture, Eulerian) controlling the governing equations. The study was conducted depending on the boiling point of the water. The activation of these three models is carried out to find out which one is better for solving the issue of boiling compared to previous numerical and empirical research with the study of the surface tension coefficient that affects the behavior of phases in a contaminated manner. The best model explored in the case of boiling is VOF for the merging of steam bubbles, the velocity of flows 0.257 m/s for both water and steam, and the phase transition. The effectiveness of the VOF model is mirrored by higher efficiency and accuracy of the solution with velocity 0.257 m/s and volume fraction 0.9997. The activation of the surface tension factor 0.072 property simulates the real conditions surrounding the materials used in boiling, but it significantly increases the turbulence and distribution of gas bubbles.
Structural behavior of tree-like steel columns subjected to combined axial and lateral loads
Authors: Dekhn Rabab C. , Shadhan Khalid K. 
Published: June 2022

Abstract
Few studies have been conducted on the structural behavior of steel columns with branches that are called tree-like columns. These kinds of columns have been used in many structures around the world. The purpose of this study is to investigate the failure load, vertical and lateral displacement, and failure mode of tree-like columns subjected to a combination of axial and lateral loading. The ratio of lateral load to axial load has been selected as the design variable. A finite element model with one branching level and two branches within the level was first developed using ABAQUS/CAE 2017 software. The model was verified with experimental results. The axial failure load and axial and lateral displacement were determined and compared for different loading ratios. The failure mode was also studied for different loading conditions. The results showed that the axial failure load decreased significantly by 54, 42, and 28% when lateral/axial loading ratio increased by 20, 40, and 60%, respectively. There was no significant decrease when lateral/axial loading ratio was more than 60%, while axial and lateral displacements increased significantly by 24% for each 20% increase in the loading ratio. Local buckling was observed as a failure mode when only gravity load is applied, while combined load resulted in lateral buckling.
Analisis Penguasaan Sintaksis Siswa Kelas IV pada Karangan Deskriptif Realistis di SD Gugus VI Kecamatan Kepanjen
Authors: Dzikria Amilatus Nurul , Rini Titis Angga , Cholifah Puri Selfi 
Published: June 2022

Abstract: Students' mastery of syntax is very diverse. This causes the teacher not to know clearly about the ownership of these assets in terms of phrase syntax and sentence syntax. This study aims to describe the syntactic description of the syntax of phrases and syntax of sentences. The approach used in this research is descriptive quantitative. The population in this study were all elementary school students in cluster 6 in Kepanjen District as many as 339 students, while the research sample was 54 students. Data collection techniques used are tests and documentation. The results showed that the students' syntax in terms of sentences and sentences was good. Suggestions given by researchers are school and teacher learning to carry out optimally, especially regarding syntax.
Abstrak: Penguasaan siswa mengenai sintaksis sangat beragam. Hal ini menyebabkan guru tidak mengetahui secara jelas mengenai penguasaan sintaksis siswa dalam segi sintaksis frasa maupun sintaksis kalimat. Penelitian ini bertujuan untuk mendeskripsikan penguasaan sintaksis siswa dari segi sintaksis frasa dan sintaksis kalimat. Pendekatan yang digunakan dalam penelitian ini yaitu kuantitatif deskriptif. Populasi dalam penelitian ini yaitu seluruh siswa SD gugus 6 di Kecamatan Kepanjen sebanyak 339 siswa, sedangkan sampel penelitian sebanyak 54 siswa. Teknik pengumpulan data yang digunakan yaitu tes dan dokumentasi. Hasil penelitian menunjukkan bahwa penguasaan sintaksis siswa dari segi frasa dan kalimat sudah baik. Saran yang diberikan oleh peneliti yaitu hendaknya sekolah dan guru bekerjasama untuk melaksanakan pembelajaran secara optimal khususnya mengenai sintaksis.
Workforce Diversity and Organizational Effectiveness in 21st Century Business Arena
Authors: Yahaya Ibrahim , Mato Umar 
Published: June 2022

The paper critically examines workforce diversity and its effect on the organizational efficiency which has become the concern of the business environment in the present globalized business Arena in the 21st century, the objectives examined the recognition of workforce diversity by organizations, the anatomy of workforce diversity, and extent of organizational workforce diversity, the researched was based on secondary data and the findings are organizations in 21st century realized and committed to workforce diversity and it concluded for business competitive advantage, strategic workforce diversity is required in the globalized organization, and its recommended the high degree of leadership and managerial commitment in action for workforce diversity.

Keyword: , , ,
Gênero e agência feminina makuxi
Authors: Cavalcante Olendina de Carvalho 
Published: June 2022

A partir de uma observação feita pelo naturalista alemão Robert Schomburgk sobre as mulheres indígenas, esse artigo discute alguns aspectos relativos ao gênero e a agência feminina, considerando experiências recentes entre as mulheres Makuxi de Roraima; pretende-se mostrar que as mulheres são agentes ativos, particularmente no âmbito da comunidade e nos movimentos sociopolíticos, além de sugerir que a situação histórica a qual se instalou no Brasil nas últimas décadas não apenas ampliou os espaços para a ação feminina, como também inovou aqueles já ocupados por elas.

Palavras-chave
Gênero; agência;Makuxi.
TECENDO A HISTÓRIA: INDÍCIOS DO SURGIMENTO DA LUTA DOS MOVIMENTOS SOCIAIS DO CAMPO EM RORAIMA
Authors: Dos Santos Maria José 
Published: June 2022

Resumo
Este artigo buscou refletir sobre o surgimento
da organização dos trabalhadores
e trabalhadoras rurais para a BR-210,
conhecida como Perimetral Norte, no
período de 1975 a 1990. Neste processo
a migração foi analisada enquanto uma
importante estratégia de resistência frente
a um longo processo de expropriação
da terra em seus estados de origem esta
interpretação foi proporcionada pela
utilização da História Social que viabiliza
o estudo das múltiplas formas de organização,
resistências e luta, valorizando
a identidade e a experiência como parte
da reflexão investigativa da construção
social. A utilização da história de vida foi
importante para identificar as estratégias
de sobrevivência, estas foram analisadas
enquanto resultado de conflitos, contradições
e construídas no tempo, no espaço
e no cotidiano. Após o acesso à terra, as
vicinais e lote tornaram-se o espaço de
convivência e surgimento da (re) organização
de suas vidas e posteriormente de sua
organização política.
Palavras-chave
Migração; Sindicalismo Rural; Resistência.
AS TRANSFORMAÇÕES DO PARTIDO DOS TRABALHADORES E O GOVERNO LULA COMO ELEMENTOS DE MANUTENÇÃO DA HEGEMONIA BURGUESA**
Authors: Vieira Rafaela 
Published: June 2022

Resumo
O presente artigo discute as transformações
ocorridas no projeto político do Partido
dos Trabalhadores (PT), analisando
seus determinantes e condicionantes históricos.
Aborda também os vínculos entre o
partido e os movimentos sociais, buscando
identificar os motivos que levaram os
grupos organizados da classe trabalhadora
a aprovarem o governo Lula.
Palavras-chave
Partido dos Trabalhadores; movimentos
sociais; governo Lula.
CONVERSÃO: UMA DISCUSSÃO SOBRE TROCA CULTURAL E ASSIMILAÇÃO DA RELIGIÃO CRISTÃ
Authors: De Souza Alfredo Ferreira 
Published: June 2022

O presente artigo tem por finalidade
estabelecer a discussão sobre encontro
cultural, mais precisamente por meio da
conversão ao cristianismo por parte de
povos tribais. Os embates existentes entre
a religião tradicional (representado pelo
xamanismo) e a religião mundial (representada
pelo cristianismo trazido pelas
missões) são complexos, principalmente
quando está em jogo a religião letrada.
Baseado nisto, o texto traz algumas discussões
que circundam este complexo tema
como, por exemplo: o perspectivismo
indígena, o solipsismo ocidental, os vários
tipos de conversão etc. Como base desta
reflexão encontra-se o diálogo com alguns
teóricos que se debruçaram sobre este
tema tais como Robbins, Hefner, Vilaça,
Sahlins dentre outros.
Palavras-chave
conversão; religião; missões cristãs; povos
tribais.
APRESENTAÇÃO, REPRESENTAÇÃO E METAFORIZAÇÃO DAS FRONTEIRAS: REFLEXÕES INTERDISCIPLINARES
Authors: Dittrich Ivo José 
Published: June 2022

O presente texto trata das dimensões antropológicas,
históricas, econômicas, políticas e jurídicas
das fronteiras, bem como as razões que as tornam
cenários tão complexos, quer por sua configuração
multifacetada, quer pelos modos como é representada
e metaforizada. As metáforas da e sobre a
fronteira constituem expressão das representações
incorporadas a partir de apresentações mediatas e
mediadas, portanto, mostram-se metodologicamente
relevantes como pontos de partida para compreender
a complexidade das fronteiras. Desta forma,
torna-se importante a abordagem de alguns aspectos
ontológicos das fronteiras, como as características
que se situam na materialidade comum às diferentes
fronteiras. Outro aspecto desta abordagem, diz respeito
às diferentes concepções ou representações que
os sujeitos sociais constroem sobre elas com base nas
suas expectativas, experiências ou interações sociais.
Por fim, as metáforas como expressão das duas instâncias
ou dimensões (apresentação-representação)
do processo de construção do conhecimento e, por
conseguinte, das bases para a comunicação social. É
evidente que essas três dimensões não estão separadas,
a não ser por razões de ordem didática, visto que
se sobrepõem, integram e, mesmo, retroalimentam:
as próprias metáforas alimentam as apresentações.
Palavras-Chave
Fronteiras; representações; metáforas.
Światłość niestworzona w refleksji teologicznej Metropolity Surożskiego Antoniego (Blooma)
Authors: Saszko Irena 
Published: June 2022

Niniejszy artykuł dotyczy refleksji teologicznej Metropolity Surożskiego Antoniego (Blooma) na temat Światłości niestworzonej. Z chwilą upadku prarodziców człowiek utracił zdolność bezpośredniego i pełnego uczestnictwa w niestworzonych Energiach Boskiej Światłości i z tego powodu może poznawać Jego misterium jedynie „w zmierzchu”, czyli w sposób apofatyczny. Z faktu stworzenia osoby ludzkiej na obraz i podobieństwo Boże wynika, że w każdym człowieku jest zarodek Boskiej Światłości. Dzięki relacji miłości z naszymi bliźnimi możemy odkrywać tę Światłość na ich obliczach. Cały Kościół jaśnieje Światłością niestworzoną, gdyż jest miejscem bezpośredniej obecności Boga pośród Swego Ludu. W nabożeństwach liturgicznych Kościoła prawosławnego, a szczególnie w Jutrzni i w Wieczerni, wierni antycypują pełne uczestnictwo w Światłości niestworzonej, która będzie ich udziałem na końcu czasów.
So What? Some Experiences of Secularism in the Netherlands and My Own Way to Handle It as a Local Pastor
Authors: Gosker Margriet 
Published: June 2022

No i co? Doświadczenia sekularyzmu w Holandii i moja droga w zmierzaniu się z nim jako lokalnej pastorki
Artykuł składa się z trzech części. We wprowadzeniu Autorka stwierdza, że istnieje wiele teorii i idei sekularyzmu, podaje również krótkie objaśnienia tego fenomenu zarówno pozytywne, jak i negatywne. Sekularyzm w Polsce jest odmienny od sekularyzmu w Holandii, która jest jednym z najbardziej zsekularyzowanych krajów Zachodniej Europy. W drugiej części Autorka ukazuje jak — jako lokalny pastor — doświadczała sekularyzmu w ostatnich pięciu dekadach: indyferentyzm, spadek zaangażowania i wiedzy biblijnej, spadek liczby ordynowanych, utrata poczucia życia sakramentalnego w Kościele, zamykanie Kościołów, zamykanie fakultetów teologicznych itd. Z drugiej strony pozytywna strona sekularyzmu objawiła się nie tylko w większej autentyczności i elastyczności w Kościele, ale również w zniesieniu niewolnictwa, większej wolności dla kobiet i dzieci oraz dla mniejszości. W trzeciej części Autorka pokazuje, jak staramy się odpowiedzieć na nowe wyzwania. W zakończeniu stawia kilka otwartych pytań, na które odpowiedzi są bardzo ważne dla całego ruchu ekumenicznego.
Sprawiedliwość ekologiczna. Programy Światowej Rady Kościołów na rzecz zachowania środowiska naturalnego
Authors: Kantyka Przemysław 
Published: June 2022

Artykuł opisuje społeczno-ekologiczne programy Światowej Rady Kościołów (ŚRK) ujęte w klamrę tzw. sprawiedliwości ekologicznej. Pierwszą z trzech wielkich grup programowych jest Ekumeniczna Sieć Na Rzecz Zaopatrzenia w Wodę. W tych programach ŚRK analizuje zależność jakości życia ludzi od dostępu do wody i urządzeń sanitarnych. Grupa programów określona jako Troska o Stworzenie i Sprawiedliwość Klimatyczna skupia się na współodpowiedzialności człowieka za Boży dar stworzenia, która powinna prowadzić do przeciwdziałania niekorzystnym zmianom klimatycznym. Dokumenty ŚRK odnoszą się tu także do tzw. długu ekologicznego oraz do pojęcia „zrównoważonego rozwoju”. Trzecią grupą programów z obszaru „eko-sprawiedliwości” są te dotyczące współzależności ubóstwa, bogactwa i ekologii (Ubóstwo, Bogactwo i Ekologia). Wskazuje się w nich na oddziaływanie na środowisko naturalne skutków rabunkowej gospodarki zasobami naturalnymi, służącej zaspokojeniu nadmiernej konsumpcji.