bluuebunny/crossref_metadata_2025_split huggingface dataset:
Can Daytime Transcranial Direct Current Stimulation Treatment Change the Sleep Electroencephalogram Complexity of REM Sleep in Depressed Patients? A Double-Blinded, Randomized, Placebo-Controlled Trial
Authors: Li Zhe , Zhao Xueli , Feng Lingfang , Zhao Yu , Pan Wen , Liu Ying , Yin Ming , Yue Yan , Fang Xiaojia , Liu Guorui , Gao Shigeng , Zhang Xiaobin , Huang Norden Eh , Du Xiangdong , Chen Rui 
Published: May 2022

Study ObjectivesThe purpose of this study was to determine the effects of daytime transcranial direct current stimulation (tDCS) on sleep electroencephalogram (EEG) in patients with depression.MethodsThe study was a double-blinded, randomized, controlled clinical trial. A total of 37 patients diagnosed with a major depression were recruited; 19 patients (13 females and 6 males mean age 44.79 ± 15.25 years) received tDCS active stimulation and 18 patients (9 females and 9 males; mean age 43.61 ± 11.89 years) received sham stimulation. Ten sessions of daytime tDCS were administered with the anode over F3 and the cathode over F4. Each session delivered a 2 mA current for 30 min per 10 working days. Hamilton-24 and Montgomery scales were used to assess the severity of depression, and polysomnography (PSG) was used to assess sleep structure and EEG complexity. Eight intrinsic mode functions (IMFs) were computed from each EEG signal in a channel. The sample entropy of the cumulative sum of the IMFs were computed to acquire high-dimensional multi-scale complexity information of EEG signals.ResultsThe complexity of Rapid Eye Movement (REM) EEG signals significantly decreased intrinsic multi-scale entropy (iMSE) (1.732 ± 0.057 vs. 1.605 ± 0.046, P = 0.0004 in the case of the C4 channel, IMF 1:4 and scale 7) after tDCS active stimulation. The complexity of the REM EEG signals significantly increased iMSE (1.464 ± 0.101 vs. 1.611 ± 0.085, P = 0.001 for C4 channel, IMF 1:4 and scale 7) after tDCS sham stimulation. There was no significant difference in the Hamilton-24 (P = 0.988), Montgomery scale score (P = 0.726), and sleep structure (N1% P = 0.383; N2% P = 0.716; N3% P = 0.772) between the two groups after treatment.ConclusionDaytime tDCS changed the complexity of sleep in the REM stage, and presented as decreased intrinsic multi-scale entropy, while no changes in sleep structure occurred. This finding indicated that daytime tDCS may be an effective method to improve sleep quality in depressed patients. Trial registration This trial has been registered at the ClinicalTrials.gov (protocol ID: TCHIRB-10409114, in progress).
A Mixed Methods Study Examining Citizenship Among Youth With Mental Health Challenges
Authors: Jordan Gerald , Burke Laura , Bailey Julia , Kreidstein Sof , Iftikhar Myera , Plamondon Lauren , Young Courtney , Davidson Larry , Rowe Michael , Bellamy Chyrell , Abdel-Baki Amal , Iyer Srividya N. 
Published: May 2022

IntroductionMultiple stakeholders have recently called for greater research on the barriers to citizenship and community belonging faced by people with mental health challenges. Citizenship has been defined as a person’s access to the rights, roles, responsibilities, resources and relationships that help people feel a sense of belonging. Factors that may impact citizenship include financial precarity; intersecting forms of marginalization and oppression (e.g., racism); and the mental health care people receive. Research has yet to examine experiences of citizenship among youth with mental health challenges. To address this gap, this study will examine how youth experience citizenship; predictors of citizenship; how citizenship shapes recovery; and the degree to which youth are receiving citizenship-oriented care.MethodsThe research objectives will be evaluated using a multiphase mixed methods research design. Quantitative data will be collected cross-sectionally using validated self-report questionnaires. Qualitative data will be collected using a hermeneutic phenomenological method using semi-structured interviews and focus groups.AnalysesMultiple stepwise regression analyses will be used to determine predictors of citizenship and if of citizenship predict recovery. Pearson correlations will be computed to determine the relationship between participants’ perceived desire for, and receipt of citizenship-oriented care. Phenomenological analysis will be used to analyze qualitative data. Findings will then be mixed using a weaving method in the final paper discussion section.ConclusionFindings from this study may support the development of citizenship-oriented healthcare in Canada.
Chronic Treatment With Psilocybin Decreases Changes in Body Weight in a Rodent Model of Obesity
Authors: Huang Joyce , Pham Michelle , Panenka William J. , Honer William G. , Barr Alasdair M. 
Published: May 2022

BackgroundThere are currently relatively few effective pharmacological treatments for obesity, and existing ones may be associated with limiting side-effects. In the search for novel anti-obesity agents, drugs that modify central serotonergic systems have historically proven to be effective in promoting weight loss. Psilocin, which is rapidly metabolized from psilocybin, is an agonist at multiple serotonin receptors. In the present study we assessed the effects of psilocybin and a positive control (metformin) on changes in body weight in a rat model of obesity.MethodsFive groups of adult male rats were pre-conditioned with a cafeteria diet until obese (&gt;600 g) and then treated with either psilocybin (0.1, 1, or 5 mg/kg, i.p.), metformin (300 mg/kg, p.o.) or vehicle control. Treatments were for 27 consecutive weekdays, and body weights and high calorie food intake were recorded daily. Fasting glucose levels were recorded after 11 days of treatment. At the end of treatment rats completed a glucose tolerance test, and multiple fat pads were dissected out to assess adiposity.ResultsThe medium dose psilocybin group had to be terminated from the study prematurely. Both the low and high dose psilocybin groups caused a significant decrease in changes in body weight compared to controls. The metformin group produced a greater decrease in change in body weight than either psilocybin groups or controls. Both high dose psilocybin and metformin decreased consumption of the high calorie diet, and exhibited decreased central adiposity.ConclusionPsilocybin demonstrated modest but significant effects on weight gain. Further study is recommended.
Risk Factors of Bone Nonfusion After Spinal Tuberculosis Debridement Bone Graft Fusion and Internal Fixation
Authors: Wei Zihan , Zhang Ying , Yang Sizhen , Ye Jiawen , Hu Xu , Li Tian , Chu Tongwei 
Published: May 2022

ObjectiveTo retrospectively analyze bone graft nonfusion risk factors in spinal tuberculosis patients after lesion debridement, bone graft fusion and internal fixation.MethodsThe clinical data of 131 patients who underwent spinal tuberculosis debridement, bone graft fusion and internal fixation in our hospital from March 2015 to March 2018 were retrospectively analyzed. The patients were divided into two groups according to bone fusion after the operation; there were 37 patients in the nonfusion group and 94 in the fusion group. The basic information and follow-up data of the patients were collected to evaluate the risk factors for bone graft nonfusion 1 year after surgery.ResultsThe severity of osteoporosis in the nonfusion group was significantly greater than that in the fusion group (p &lt; 0.05). There were statistically significant differences between the two groups in terms of continuous multisegment status, disease duration, intraoperative surgical methods and whether patients received standardized drug treatment for 12 months after surgery (p &lt; 0.05). Multivariate logistic regression analysis showed that long disease duration, posterior approach, and degree of osteoporosis were risk factors for postoperative bone graft nonfusion (OR &gt; 1,p &lt; 0.05), while standard drug treatment for 1 year after surgery was a protective factor (OR &lt; 1,p &lt; 0.05).ConclusionSpinal tuberculosis patients who had a long disease course, who underwent simple posterior debridement, or who had severe osteoporosis had a higher risk of bone graft nonfusion after surgery. Tuberculosis treatment is beneficial for the osseous fusion of the postoperative bone graft area.
A Systematic Review and Meta-Analysis of the Risk of Stillbirth, Perinatal and Neonatal Mortality in Immigrant Women
Authors: Behboudi-Gandevani Samira , Bidhendi-Yarandi Razieh , Panahi Mohammad Hossein , Mardani Abbas , Gåre Kymre Ingjerd , Paal Piret , Vaismoradi Mojtaba 
Published: May 2022

Objectives: This study aimed to investigate the risk of stillbirth, perinatal and neonatal mortality in immigrant women compared to native-origin women in host countries.Methods: A systematic literature review and meta-analysis was conducted. Relevant studies were identified using a thorough literature search and their quality was appraised. The analysis of heterogeneous data was carried out using the random effects model and publication bias was assessed using the Harbord-test. Also, the pooled odds ratio of events was calculated through the DerSimonian and Laird, and inverse variance methods.Results: In the search process 45 studies were retrieved consisting of 8,419,435 immigrant women and 40,113,869 native-origin women. The risk of stillbirth (Pooled OR = 1.35, 95% CI = 1.22–1.50), perinatal mortality (Pooled OR = 1.50, 95% CI = 1.35–1.68), and neonatal mortality (Pooled OR = 1.09, 95% CI = 1.00–1.19) in the immigrant women were significantly higher than the native-origin women in host countries. According to the sensitivity analyses, all results were highly consistent with the main data analysis results.Conclusion: The immigrant women compared to the native-origin women had the higher risks of stillbirth, perinatal and neonatal mortality. Healthcare providers and policy makers should improve the provision of maternal and neonatal healthcare for the immigrant population.
Preliminary Checklist of Malaxidinae and Liparidinae Representatives (Orchidaceae, Malaxideae) from Bali and Lombok Islands (Indonesia) with New Records
Authors: Margońska Hanna B. , Champion Jeffrey , Lipińska Monika M. 
Published: May 2022

Bali and Lombok are well known as popular touristic destinations. Both islands are accessible for potential floristic research, but surprisingly, information on their orchid flora is rather scarce and random. During our visits, among other orchid groups, we had an opportunity to observe several representatives of the tribe Malaxideae, which is considered to be one of the biggest and most interesting orchid groups with over 1700 taxa (including synonyms). In this paper, we present the first attempt at organizing the knowledge about these unique, often underestimated, orchids in Bali and Lombok, and we report several new records for both islands. For Bali, there are six from the genus Crepidium and four from Liparis sensu lato, and for Lombok, one from Crepidium and three from Liparis sensu lato.
Age Modifies Intracranial and Gastrointestinal Bleeding Risk from P2Y12 Inhibitors in Patients Receiving Dialysis
Authors: Jain Nishank , Martin Bradley C. , Dai Junqiang , Phadnis Milind A. , Al-Hindi Layth , Shireman Theresa I. , Hedayati S. Susan , Rasu Rafia S. , Mehta Jawahar L. 
Published: May 2022

Background
Individuals aged ≥75 years are the fastest-growing population starting dialysis for end-stage kidney disease (ESKD) due to living longer with coronary artery disease. ESKD alone can increase bleeding risk, but P2Y12 inhibitor (P2Y12-I) antiplatelet medications prescribed for cardiovascular treatment can exacerbate this risk in patients with ESKD. The age-specific rates of bleeding complications in dialysis patients with ESKD on P2Y12-I remain unclear, as does how age modifies the bleeding risk from P2Y12-I use in these patients.

Methods
In a retrospective cohort study, we collected data on 40,972 patients receiving maintenance hemo- or peritoneal dialysis who were newly prescribed P2Y12-I therapy between 2011 and 2015 from the USRDS registry. We analyzed the effect of age on the time to first bleed and the interactions between age and P2Y12-I type on modifying the effects of a bleed.

Results
Twenty percent of the cohort were aged ≥75 years. There were 3096 (8%) gastrointestinal (GI) and 1298 (3%) intracranial (IC) bleeding events during a median follow-up of 1 year. Annual incidence rates for IC bleeds were 2% in those aged <55 years and 3% in those aged ≥75 years. Rates for GI bleeds were 4% in those aged <55 years and 9% in those aged ≥75 years. On clopidogrel, prasugrel, and ticagrelor, for every decade increase in age of the cohort members, the risk of IC bleed increased by 9%, 55%, and 59%, and the risk of GI bleed increased by 21%, 28%, and 39%, respectively. At age ≥75 years, prasugrel was associated with a greater risk of IC bleed than clopidogrel. At age ≥60 years, ticagrelor was associated with a greater risk of GI bleed than clopidogrel.

Conclusions
More potent P2Y12-Is (prasugrel and ticagrelor) were associated with a disproportionately higher risk of IC bleed with increasing age compared with that of clopidogrel—prasugrel was much worse than clopidogrel at age ≥75 years. All three drugs were associated with only modest increase in the risk of GI bleed with every decade increase in age—ticagrelor was much worse than clopidogrel at ≥60 years of age. These results highlight the need for head-to-head clinical trials for the use of P2Y12-Is in patients with ESKD to determine age cutoffs where the risk of bleeding outweighs the benefits of thrombosis prevention.
Para que existem padrões?
Authors: Cajango Eunice , Sales Elielson Ribeiro de 
Published: May 2022

Este estudo visa apresentar uma intervenção pedagógica fundamentada em pressupostos freireanos como uma possibilidade didática para o ensino de matemática em uma classe hospitalar. Para tanto, descrevemos uma atividade desenvolvida a partir do tema gerador Para que existem padrões?, com o objetivo de dialogar sobre questões referentes à identidade ética e estética de um grupo de educandas em tratamento de saúde, relacionando-a à compreensão de unidades de medida. A investigação qualitativa foi realizada em uma classe hospitalar vinculada à Secretaria de Educação do Pará, situada em Belém, com base em princípios da comunicação matemática a partir da escuta ativa. Concebemos que, a partir da abordagem não-hierarquizada de saberes vinculados ao tema gerador, foi possível propiciar às educandas um ambiente de aprendizagem no qual suas vivências e reflexões foram valorizadas, contribuindo para a construção de conhecimento matemático amparado em uma visão crítica e ética de padrões historicamente constituídos.
Palavras-chave: Classe Hospitalar. Educação Matemática. Princípios Freireanos. Escuta Ativa. Temas geradores.
Looks in search of the meaning of the human suffering
Authors: Salazar Garcia Abel Antonio 
Published: May 2022

This text presents the terms pain and suffering that we often use interchangeably in our daily lives and how both involve, trap, disturb the individual; the suffering of the innocent is occurring in a very special way. So, to understand the effects of pain and suffering, we will mention the realms that encompass the human being, and how they perceive it. Suffering is perceived in an existential reality that affects the individual when it occurs and continues in many cases leaving consequences in its wake, and what options are presented to us to face it or let ourselves be dragged by it.
RENEWABLE ENERGY PLANNING ANALYSIS SOLAR ROOF SYSTEM
Authors: April Karseno , Siregar Masbah R.T 
Published: May 2022

Planning for renewable energy for solar roof systems on house types 36,50 and 70 with the on-grid rooftop solar system design. Solar roofs are more aesthetically appealing and sleeker, the appearance of the roof is amazing which has a choice between textured tiles that blend into the building and can provide many advantages. Using the theory of calculating the area of the roof in the form of a prism, it can be seen the optimization of the area of the solar roof. The calculation results obtained, the larger the type of house and the length of the potential solar roof and the width of the potential solar roof, the more extensive the optimization of the solar roof area, the larger the type of house and the number of solar roof tiles required, the heavier the dimensions of the weight of the solar roof, the electric power. generated by the solar roof has the potential to save electricity to PLN, the economic investment of the solar roof that needs to be prepared with the calculation results for type 36 houses valued at Rp.194,504,000, type 50 Rp. 268,321,000 and type 70 Rp. 335,296,000.
PERANCANGAN INTERNET OF THINGS (IOT) SMART HOME
Authors: Zein Afrizal , Eriana Emi Sita 
Published: May 2022

The main purpose of this research is to design a smart home using IoT where the technology is to automate various activities at home such as turning off and turning on the lights, television, air conditioner, fan sound system and opening the gate. All devices are connected to the internet via a router, to allow remote monitoring and control of various household appliances. In this paper, I implemented a smart home using the newly released cisco tracer package simulation software, because different IoT devices used for home automation are included in this new version of the simulator. The previous software only had network devices, but in the newly released IoT simulator devices are included sensors, boards, IoT devices. To smartly design the house I use different devices that are used for home security, safety and well-being of the home environment.

Keywords: IoT, Smart home, packer tracer, sensor.
OPTIMASI STRUKTUR JACKET LEPAS PANTAI DENGAN ANALISIS PERMODELAN KOMPUTASI 3D NONLINIER PUSHOVER
Authors: Sundoro Amin , Taufik Syahril 
Published: May 2022

ABSTRACT
This study emphasizes the collapse of the offshore jacket platform structure model due to lateral loads, namely environmental loads with the help of USFOS computing software. The optimized platform structure model is the A model with 4 legs with a combination of X, V, Chevron, and K diagonal bracings. Then, step by step the bracing is progressively reduced until the first yield load level of the component is below 1 or the structure does not meet the design level criteria. The analysis used is nonlinear pushover from extreme storms. The platform model A was analyzed from 8 metocean directions and the next model was analyzed using the storm direction with the smallest RSR value from model A, namely the direction of 225°. The results of the analysis show changes in the global collapse mechanism, components that experience the first yield and changes in ductility. From the results of the scoring between the weight ratio of model A to the weight of the models with the redundancy value, the largest value obtained is the Platform E hybrid model with 4X bracing, 2 Chevrons, and 4 vertical diagonal models K with steel grade S315. The weight that can be optimized by the E Hybrid model from the A model is 101,801 kN, optimum 2,88% and redudancy factor reached 198.20%.
Keywords: Extreme storm, Collapse mechanism, Nonlinear Pushover, Redundancy, Ductility
From Pericenter and Back: Full Debris Stream Evolution in Tidal Disruption Events
Authors: Bonnerot Clément , Pessah Martin E. , Lu Wenbin 
Published: May 2022

Abstract
When a star passes too close to a supermassive black hole, it gets disrupted by strong tidal forces. The stellar debris then evolves into an elongated stream of gas that partly falls back toward the black hole. We present an analytical model describing for the first time the full stream evolution during such a tidal disruption event (TDE). Our framework consists of dividing the stream into different sections of elliptical geometry, whose properties are independently evolved in their comoving frame under the tidal, pressure, and self-gravity forces. Through an explicit treatment of the tidal force and the inclusion of the gas angular momentum, we can accurately follow the stream evolution near pericenter. Our model evolves the longitudinal stream stretching and both transverse widths simultaneously. For the latter, we identify two regimes depending on whether the dynamics is entirely dominated by the tidal force (ballistic regime) or additionally influenced by pressure and self-gravity (hydrostatic regime). We find that the stream undergoes transverse collapses both shortly after the stellar disruption and upon its return near the black hole, at specific locations determined by the regime of evolution considered. The stream evolution predicted by our model can be used to determine the subsequent interactions experienced by this gas that are at the origin of most of the electromagnetic emission from TDEs. Our results suggest that the accretion disk may be fed at a rate that differs from the standard fallback rate, which would provide novel observational signatures dependent on black hole spin.
A New Method for Measuring Infrared Band Strengths in H2O Ices: First Results for OCS, H2S, and SO2
Authors: Yarnall Yukiko Y. , Hudson Reggie L. 
Published: May 2022

Abstract
Infrared (IR) band strengths are needed to extract accurate molecular abundances from astronomical observations of interstellar and solar system ices. However, laboratory measurements of such intensities often have required multiple assumptions about ice composition and thickness. Here we describe a method that circumvents most of the common assumptions and uncertainties in IR band-strength determinations. We have applied the method to measure IR band strengths of OCS, H2S, and SO2 in the absence and presence of H2O ice at 10 K, the first measurements of their type. Our results show for the first time that the presence of H2O makes little difference in IR intensities for these three sulfur-containing molecules’ strongest IR features. The immediate application will be to laboratory studies of low-temperature chemistry of interstellar and cometary ices.
Detecting the Memory Effect from a Massive Black Hole Merger at the Galactic Center through Lunar Ranging
Authors: Loeb Abraham 
Published: May 2022

Abstract
A gravitational wave pulse from a major merger of massive black holes at the Galactic center induces a permanent increase in the Earth–Moon separation. For black holes of mass ∼106
M
⊙, the shift in the local gravitational potential is comparable to the Earth–Moon potential, leading to the Moon being perturbed relative to the Earth during the passage of the pulse. The permanent increase in the Earth–Moon separation is a fraction of a millimeter, measurable by lunar ranging for future merger events.
A newly discovered southern HgMn star: HD 4065A
Authors: Monier Richard , Niemczura Ewa 
Published: May 2022

Abstract
Evidence is presented that HD 4065A is a newly discovered HgMn star. The Hg ii line at 3983.93 Å is present in two spectra acquired with the High Resolution Spectrograph mounted behind the South African Large Telescope and separated by about 2 months and 25 days. The lines on the second spectrum are redshifted reflecting the orbital motion of HD 4065A around the center of mass of a binary system. The far-ultraviolet spectrum, SWP 20399 collected with IUE, shows a strong resonance line of Ga ii usually conspicuous in the far-ultraviolet spectra of HgMn star. A first spectrum synthesis of the spectral range from 3900 up to 4000 Å yields estimates of the abundances of calcium (0.10 solar), zirconium (25 solar) and mercury (50,000 solar).