bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cognitive Processing Therapy or Relapse Prevention for comorbid Posttraumatic Stress Disorder and Alcohol Use Disorder: A randomized clinical trial
Authors: Simpson Tracy L. , Kaysen Debra L. , Fleming Charles B. , Rhew Isaac C. , Jaffe Anna E. , Desai Sruti , Hien Denise A. , Berliner Lucy , Donovan Dennis , Resick Patricia A. 
Published: November 2022

ObjectiveTo compare a Posttraumatic Stress Disorder (PTSD) treatment (Cognitive Processing Therapy; CPT), an Alcohol Use Disorder (AUD) treatment (Relapse Prevention; RP), and assessment-only (AO) for those meeting diagnostic criteria for both PTSD and AUD.MethodParticipants with current PTSD/AUD (N = 101; mean age = 42.10; 56% female) were initially randomized to CPT, RP, or AO and assessed post-treatment or 6-weeks post-randomization (AO). AO participants were then re-randomized to CPT or RP. Follow-ups were at immediate post-treatment, 3-, and 12-months. Mixed effects intent-to-treat models compared conditions on changes in PTSD symptom severity, drinking days, and heavy drinking days.ResultsAt post-treatment, participants assigned to CPT showed significantly greater improvement than those in AO on PTSD symptom severity (b= -9.72,95% CI[-16.20, -3.23],d =1.22); the RP and AO groups did not differ significantly on PTSD. Both active treatment conditions significantly decreased heavy drinking days relative to AO (CPT vs. AO:Count Ratio [CR]= 0.51,95% CI[0.30, 0.88]; RP vs. AO:CR= 0.34,95% CI[0.19, 0.59]). After re-randomization both treatment conditions showed substantial improvements in PTSD symptoms and drinking between pre-treatment and post-treatment over the 12-month follow-up period, with RP showing an advantage on heavy drinking days.ConclusionTreatments targeting oneorthe other aspects of the PTSD/AUD comorbidity may have salutary effects on both PTSD and drinking outcomes. These preliminary results suggest that people with this comorbidity may have viable treatment options whether they present for mental health or addiction care.Trial registrationThe trial is registered at clinicaltrials.gov (NCT01663337).
Wealth-based inequality in the exclusive use of hygienic materials during menstruation among young women in urban India
Authors: Singh Aditya , Chakrabarty Mahashweta , Singh Shivani , Mohan Diwakar , Chandra Rakesh , Chowdhury Sourav 
Published: November 2022

Background
The exclusive use of hygienic materials during menstruation (sanitary napkins, locally made napkins, tampons, and menstrual cups) among urban women in India has been increasing over time. However, little is known about the wealth-based disparity in the exclusive use of hygienic materials during menstruation among these women. This study, therefore, measures wealth-based inequality in the exclusive use of hygienic materials during menstruation among urban women in India. Furthermore, the measured inequality is decomposed to unravel its contributing factors.

Data and methods
Using data from the National Family Health Survey-5 (2019–21), we calculated the Erreygers normalized concentration index (CI) for India and each of its states to measure wealth-based inequality in the exclusive use of hygienic materials during menstruation among women in urban India. Further, we decomposed the Erreygers CI to estimate the relative contribution of covariates to wealth-based inequality in the exclusive use of hygienic materials during menstruation. The analysis included 54,561 urban women aged 15–24 from 28 states and eight union territories of India.

Results
The Erreygers CI value of 0.302 indicated a pro-rich inequality in the exclusive use of hygienic materials among urban women in India. While all the states and UTs showed pro-rich inequality, the CI varied considerably across the country. Among the bigger states, the inequality was highest in Madhya Pradesh (CI: 0.45), Assam (CI: 0.44), Bihar (CI: 0.41), and West Bengal (CI: 0.37) and the lowest in the south Indian states of Tamil Nadu (CI: 0.10), Andhra Pradesh (CI: 0.15), Telangana (CI: 0.15), and Kerala (CI: 0.20). Erreygers decomposition revealed that wealth-based inequality in women’s education and mass media exposure contributed almost 80% of the wealth-based inequality in the exclusive use of hygienic materials during menstruation among urban women in India.

Conclusion
Substantial pro-rich inequality in the exclusive use of hygienic materials suggests that the policies and program initiatives should prioritize reaching out to poor women to increase the overall rate of exclusive use of hygienic materials during menstruation in urban India.
“If I get sick here, I will never see my children again”: The mental health of international migrants during the COVID-19 pandemic in Chile
Authors: Blukacz Alice , Cabieses Báltica , Obach Alexandra , Madrid Paula , Carreño Alejandra , Pickett Kate E. , Markkula Niina 
Published: November 2022

BackgroundThe COVID-19 pandemic has had an impact on the mental health of international migrants globally. Chile has managed its response to the pandemic in an ongoing context of social unrest and combined regional migratory and humanitarian crisis. The country’s population presents a high prevalence of common mental disorders and a high suicide rate, with limited access to mental healthcare. International migrants in Chile represent 8% of the total population, and although a socioeconomically heterogenous group, they face social vulnerability, a range of mental health stressors and additional barriers to access mental healthcare. This study describes the mental health outcomes, stressors, response, and coping strategies perceived by international migrants during the COVID-19 pandemic in Chile.Methods and findingsA qualitative case study was carried out through individual online interviews to 30 international migrants living in Chile during the pandemic and 10 experts of the social and health care sectors. An inductive content analysis was carried out, a process during which the researchers sought to identify patterns and themes derived from the data. Participants experienced mainly negative mental health outcomes, including anxiety and depression symptomatology. Stressors included the virus itself, work, living and socioeconomic conditions, discrimination, fear for their family and distance caring. Institutional responses to address the mental health of international migrants during the pandemic in Chile were limited and participants relied mainly on individual coping strategies.ConclusionsThe pandemic can represent an important opportunity to strengthen mental health systems for the general population as well as for population groups experiencing social vulnerability, if the issues identified and the lessons learned are translated into action at national, regional, and international level. Promoting the mental health of international migrants means recognising migration as a social determinant of mental health and adopting a cross-cultural as well as a Human Rights approach.
Health-related quality of life and estimation of the minimally important difference in the Functional Assessment of Cancer Therapy-Endocrine Symptom score in postmenopausal ER+/HER2- metastatic breast cancer with low sensitivity to endocrine therapy
Authors: Kikawa Yuichiro , Hagiwara Yasuhiro , Fujisawa Tomomi , Araki Kazuhiro , Iwamoto Takayuki , Sangai Takafumi , Shien Tadahiko , Takao Shintaro , Nishimura Reiki , Takahashi Masato , Toyama Tatsuya , Aihara Tomohiko , Mukai Hirofumi , Taira Naruto 
Published: November 2022

Background
The HORSE-BC study previously demonstrated that second-line endocrine therapy (ET) for patients with acquired endocrine-resistant metastatic breast cancer (MBC) still provided a clinically meaningful benefit. Herein, we investigated the health-related quality of life (HRQOL) in the HORSE-BC study.

Methods
Patients with acquired endocrine-resistant MBC who were scheduled for second-line ET were recruited. The HRQOL was assessed at baseline, and 1 and 3 months after second-line ET initiation. To investigate the minimally important difference (MID) in the Functional Assessment of Cancer Therapy-Endocrine Symptoms (FACT-ES), we evaluated the means and standard deviations for the distribution-based method, and differences in the change in HRQOL for the anchor-based method. We also investigated the association between FACT-ES total scores and clinical benefit.

Results
Overall, 56 patients were enrolled. Of these, 47 were analyzed. When defined as 1/3 standard deviation estimates based on the distribution method, the calculated MID was 5.9. The MIDs of the FACT-ES total scores based on the anchor method were 7.7 for decline and 4.1 for improvement. The MID decline proportions were 6.1% and 14.7% lower in patients who experienced clinical benefits than in those who did not at 1 and 3 months, respectively. The ratios of MID improvement in patients who experienced clinical benefits were 18.3% and 3.2% higher, respectively; the mean change in the FACT-ES total score from baseline improved in patients who experienced clinical benefits.

Conclusions
Maintaining the HRQOL as determined by FACT-ES may be associated with clinical benefits in patients with acquired endocrine-resistant MBC treated with ET.
Phenotypes of body composition in patients with systemic sclerosis
Authors: Toroptsova N. V. , Sorokina A. O. , Dobrovolskaya O. V. , Demin N. V. 
Published: November 2022

Background. Systemic sclerosis (SSc) is an autoimmune inflammatory disease of connective tissue with a polysyndromic clinical picture. One of the factors that significantly affect the quality of life of such patients is the involvement of the musculoskeletal system. A small number of studies were aimed at studying osteoporosis and body composition in patients with SSc, however, the clinical heterogeneity of the disease, a small number of patients included in the studies do not allow to draw unambiguous conclusions about the frequency of various phenotypes of body composition, their relationship and factors affecting their occurrence.Aim. To study the body composition and to establish the frequency of isolated and combined pathological phenotypes in women with SSс and to determine the factors associated with the muscle mass.Materials and methods. 85 postmenopausal women (46 with SSc, 39 without rheumatic pathology) were included. Questionnaires, anthropometric measurements, assessment of nutritional status by MNA, dual-energy X-ray absorptiometry of the whole body, lumbar spine, femoral neck and total hip were carried out. Correlation and univariate linear regression analyses were performed to identify factors related to appendicular muscle mass.Results. Normal body composition was found in 13.0% of patients with SSс and 25.6% — in the control, isolated and combined pathological phenotypes were detected in 34.8% and 52.2% women with SSс and in 61.5% and 12.8% in the group without rheumatic diseases, respectively. Combined pathological phenotypes, phenotypes with the presence of sarcopenia and/or osteoporosis were significantly more often in SSc patients (p< 0.001), but the frequency of obesity did not differ (69.6% and 64.1%, respectively). Negative correlations were revealed between the value of appendicular muscle mass and the presence of osteolysis of the nail phalanges (Rs=-0.23), the cumulative dose of glucocorticoids (GC) (Rs=-0.43) and direct — with the value of the femoral neck BMD (Rs=0.47), nutritional status by MNA (Rs=0.51), BMI (Rs=0.70), the circumference of the shoulder of the non-dominant arm (Rs=0.68), waist (Rs=0.66), hips (Rs=0.72) and lower leg of the non-dominant leg (Rs=0.81), p< 0.05. Univariate linear analysis confirmed the presence of positive associations between the appendicular muscle mass and proximal hip BMD, BMI, shoulder circumferences, waist, hips and lower leg (p< 0.001), and negative associations with the Rodnan skin score (p=0.012) and the cumulative dose of GC (p=0.001).Conclusion. 87% of patients with SSc had pathological phenotypes of body composition, among them combined phenotypes were significantly more common than in people without rheumatic diseases. BMD in the proximal hip, BMI, circumference of the shoulder, waist, hips and lower leg were positively, and the Rodnan skin score and cumulative dose of GC were negatively associated with the appendicular muscle mass.
Anti-Ki/anti-PA28γ autoantibodies contribute to the HEp-2 indirect immunofluorescence nuclear speckled pattern
Authors: Boon Lise , Belmondo Thibaut , Vulsteke Jean-Baptiste , Wuyts Greet , Derua Rita , Hüe Sophie , Bossuyt Xavier 
Published: November 2022

Abstract

Objectives
Antinuclear antibodies (ANAs) are associated with several autoimmune diseases. Indirect immunofluorescence (IIF) on human epithelial type 2 (HEp-2) cells is the golden standard for ANA detection in the clinic. In case of a positive HEp-2 IIF test result, follow-up tests are done to determine autoantibody specificity. For a fraction of the HEp-2 IIF-positive samples, the nature of the autoantigens remains uncharacterized. Our objective was to characterize autoantigens in such samples.

Methods
To characterize autoantigens in an unbiased way, we combined protein immunoprecipitation with liquid chromatography (LC) tandem mass spectrometry (MS/MS) sequencing.

Results
Using such approach we detected the Ki antigen, also referred to as PA28γ, in the immunoprecipitate of serum samples of three individuals with an autoimmune disease. The HEp-2 nuclear speckled IIF fluorescent signal of all three serum samples was abolished after pre-absorption of the serum with recombinant Ki antigen, confirming that autoantibodies against Ki underlie the HEp-2 IIF signal.

Conclusions
Our data suggest that anti-Ki autoantibodies can underlie a nuclear speckled HEp-2 IIF pattern.
Piezo-, photo- and piezophotocatalytic activity of electrospun fibrous PVDF/CTAB membrane
Authors: Rabadanova Alina , Abdurakhmanov Magomed , Gulakhmedov Rashid , Shuaibov Abdulatip , Selimov Daud , Sobola Dinara , Částková Klára , Ramazanov Shikhgasan , Orudzhev Farid 
Published: November 2022

A composite material based on polyvinylidene fluoride (PVDF) nanofibers modified with cetyltrimethylammonium bromide (CTAB) was synthesized by coaxial electrospinning. The morphology and structure of the material were studied by SEM, FTIR spectroscopy, X-ray diffraction analysis, XPS, and the piezo-photo- and piezo-photocatalytic activity during the decomposition of the organic dye Methylene blue (MB) was studied. It is shown that the addition of CTAB promotes additional polarization of the PVDF structure due to ion-dipole interaction. It has been shown for the first time that the addition of CTAB promotes the photosensitivity of the wide-gap dielectric polymer PVDF (the band gap is more than 6 eV). It was demonstrated that the photocatalytic decomposition efficiency was 91% in 60 minutes. The material exhibits piezocatalytic activity – 73% in 60 minutes. Experiments on trapping active oxidizing forms have established that OH hydroxyl radicals play the main role in the photocatalytic process.
Investigating the Decreased Bone Density Prevalence in People with Common Risk Factors Referred to Al-Zahra Educational-Medical Center in Isfahan City Years of 2018 and 2019
Authors: Mousavi Maryam , Pakzad Bahram , Ebrahimian Maryam 
Published: November 2022

Introduction: Osteoporosis is a disease in skeletal system that is recognized by a lack of bone density and degeneration of bone tissue and can lead to increase the risk of bone fracture or even death. So, this study was conducted to determine the prevalence of decreased bone density in people with common risk factors referred to Al-Zahra Educational-Medical Center in Isfahan City years 2018-2019.
Methods: This was a cross-sectional study. 3780 participants were included in the study by census sampling from April 2018 to March 2019. The risk factors considered in this study included gender, age, menopausal age, body mass index, history of mild trauma or fracture after the age of 40, hip fracture, autoimmune diseases, corticosteroid use, diabetes, hypothyroidism, hyperthyroidism, liver diseases, kidney diseases, malnutrition, alcohol consumption, smoking, and weight loss. Patients underwent bone densitometry. The criterion for diagnosing osteoporosis is T score, which indicated the ratio of an individual's bone density to baseline. Data were collected by a checklist and then analyzed in SPSS software version 16 at a significance level of 0.05.
Results: The hip T-score in 1780 (47.1%) individuals and the spine T-score in 1724 (45.6%) individuals were between -1 and -2.5. There was a significant relation among gender, age, height, weight and body mass index, corticosteroid use, chronic kidney disease, premature menopause, hyperthyroidism, weight loss, autoimmune diseases, hip fracture, and the history of trauma or fracture after the age of 40. hip T score, and there was a significant relationship between age, height, weight and body mass index, hyperthyroidism, weight loss, premature menopause, corticosteroid use, (P> 0.05). Spine T score was related to factors such as age, height, weight and body mass index, hyperthyroidism, weight loss, early menopause, corticosteroid use, history of trauma or fracture after 40 years (P<0.05).
Conclusion: This study showed that the prevalence of osteoporosis increases with age, and especially women with early menopause, and also in people with a history of trauma or fracture over the age of 40, hip fracture, corticosteroid use, hyperthyroidism, and autoimmune disease, chronic kidney disease, obesity and weight loss are common. Therefore, in order to prevent osteoporosis, necessary measures should be taken to prevent and correct the risk factors.
An investigation of mission differentiation and specialization in Turkish universities in the context of strategic objectives
Authors: Karadağ Nazife , Balkar Betül 
Published: November 2022

This study examines and compares the strategic objectives of the universities included in the “mission differentiation and specialization on the basis of regional development” project carried out in the Turkish higher education system and well-established universities in Turkiye. Therefore, the aim of this study is to determine how the goal of “mission differentiation and specialization on the basis of regional development” is tried to be realized in the higher education system and whether this goal really brings a difference to the activities of universities. The study was conducted through document review. The universities included in the study were determined by criterion sampling and two different study groups were formed for comparison. The first study group consisted of the universities involved in the mission differentiation project. The second study group consisted of the well-established universities located in various geographical regions of Turkiye. Data were analyzed through the content analysis. The strategic objectives of the universities were examined under the themes of increasing quality in education, increasing the quantity and quality of scientific research, improvement of communication and interaction with stakeholders, strengthening of corporate identity/structure/ensuring institutionalization and internationalization. The strategic objectives of the universities with mission differentiation are also analyzed in terms of leading local and regional development. The results of the research show that universities subject to mission differentiation and well-established universities have different qualifications only in terms of “leading local and regional development” and “strengthening community service studies.” However, there are also points where goals and performance indicators depending on these strategic objectives are resembled. The similarities in the strategic objectives of the universities show that the missions of the universities with mission differentiation and specialization should first be clarified based on a general framework provided by the Council of Higher Education. In line with the guiding framework, universities should establish their unique strategic objectives in the strategic planning process in order to contribute to regional development.
Received: 20 October2021Accepted: 7 October 2022
Beyond performance-based budgeting policy in Iran’s public universities: Causes, outcomes, and strategies
Authors: Faramarzi Nia Zargham , Farhadi Rad Hamid , Mehralizadeh Yadollah , Gholipour Soteh Rahmatullah 
Published: November 2022

The main aim of the present study was to analyze the causes, outcomes, and strategies of performance-based budgeting in the Iranian higher education system. To this end, a qualitative approach based on the grounded theory was used. In order to collect reliable data, in-depth semi-structured interviews were conducted with two groups of experts who were selected by purposive sampling method based on the selection of desirable cases. After qualitative content analysis of the collected information via encoding, the detailed report preparation method and comparison with expert opinions were taken into account to validate the findings. At a significance level of 0.0001, the kappa measure of agreement was 0.786. The results showed that finding a suitable mechanism to ensure accountability and transparency in universities was the main focus of performance-based budgeting approach, and its implementation was affected by various factors at the macro level (government) and micro level (university). Positive outcomes of this budgeting model include improved accountability and transparency, project- oriented nature of the model, and improved efficiency and effectiveness. Besides, threat to the nature and independence of the university was possibly a negative consequence of this plan. To use the benefits simultaneously and avoid the negative consequences, various strategies were proposed, including the expansion of the authority, independence, and freedom of the university and the involvement of the university’s senior managers.
Received: 10 March 2022Accepted: 15 August 2022