bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mechanism of Chlorpyrifos Induced Chronic Nephrotoxicity
Authors: Aung Sanda , Talib A. Norlelawati , Abdullah Nor Zamzila , Zainone Zamzuria Mat 
Published: October 2022

INTRODUCTION: Chlorpyrifos is one of the most commonly used organophosphates in agriculture. Report on animal models of chronically exposed chlorpyrifos showed significant histo-structural renal damage. Moreover, evidence of high incidence of diabetes mellitus were observed among agricultural workers exposed to organophosphates. Available evidence linking derangement of glucose metabolism pathway with renal damage in this chronically exposed chlorpyrifos is lacking. The aim of this study was to determine the involvement of advanced glycation end-products formation in the development of nephrotoxicity in animals with chronic subcutaneous exposure to chlorpyrifos. MATERIALS AND METHODS: Eighteen rats were divided into three groups, with six rats in each group. Group 1 served as a control group, while Groups 2 and 3 received subcutaneous 3% dimethyl sulfoxide and 97% volume per volume soy oil as a vehicle or chlorpyrifos, respectively, alternate day for 180 days. Blood samples were taken for biochemical analysis. Kidney tissues were examined for immunohistochemistry and gene expression of pathways related to oxidative stress and advanced glycation end-products. RESULTS: Serum fasting glucose, creatinine, advanced glycation end-products and malondialdehyde levels were significantly increased (p<0.05), whereas paraoxonase-1 level was decreased in chlorpyrifos-treated rats compared with the control groups (p<0.05). The proximal tubular cells and the glomeruli of chlorpyrifos-exposed kidney showed strong malondialdehyde and advanced glycation end-products expression respectively. Gene expression of catalase and glutathione reductase were downregulated in the chlorpyrifos-treated rats. CONCLUSION: Glucose derangement and oxidative stress are the possible mechanisms of organophosphate-induced kidney damage.
Detection of FMS-Like Tyrosine Kinase 3 (FLT3) and Nucleophosmin 1 (NPM1) Mutations from Marrow Tissues in Patients with Acute Myeloid Leukaemia
Authors: Hamdan Asmah Hanim , Mansoor Mohammad Naeem , Muhammad Naznin , A. Taliba Norlelawati , Ismail Rusmawati , Ibrahim Ismail , Abd Aziz Karimah Hanim 
Published: October 2022

INTRODUCTION: Acute myeloid leukaemia is a haematological malignancy with diverse cytogenetic abnormalities and molecular mutations. Amongst the important mutations are FMS-related tyrosine kinase 3 (FLT3) and nucleophosmin 1 (NPM1) gene mutations. These mutations have been shown to be of prognostic significance. A cross-sectional study to examine the frequency of these mutations and their association with the haematological and cytogenetic characteristics of the cases was carried out in Kuantan, Pahang, Malaysia. MATERIALS AND METHODS: A total of 43 cases were included in the study. Polymerase chain reaction-based assays were employed for mutation detection from the retrieved trephine biopsy tissue blocks. Mutation positivity was subsequently validated by Sanger DNA sequencing. RESULTS: Six of the 43 cases (14.0%) of the acute myeloid leukaemia were positive for FLT3-type internal tandem duplications (FLT3-ITD) and a similar proportion (6/43, 14.0%) were positive for NPM1 mutations. FLT3 mutations at codon D835 (FLT3-D835) mutation was identified in three of the cases (7.0%) while concurrent mutations of NPM1 and FLT3-ITD were seen in two of the mutation-positive cases (4.7%). The total white cell count was found to be significantly higher in patients with FLT3 mutations (p=0.001). Other haematological parameters and the cytogenetic results did not reveal any significant association with the mutational status. CONCLUSION: The frequency of FLT3-ITD, FLT3-D835, and NPM1 mutations among AML patients were 14%, 7%, and 14% respectively. Follow-up studies to include the clinical parameters and the treatment outcomes are advocated.
a Projected Motion Sebagai Media Pembelajaran IPA SD Materi Pentingnya Upaya Pelestarian SDA di Lingkungan
Authors: Iis Yanawati Alfina Bakti Pertiwi 
Published: October 2022

The continued existence of conventional learning in elementary school science subjects has left 4th graders without fully understanding the concept of science and of underinterest in student study. Therefore it takes the right media to use the development of technology to give us an understanding of the concept of science. One approach is by using surgical motion media. The purpose of this learning media development is for students to learn in accordance with the cognitive development stage, so that students can understand the science concept, matter of the importance of preserving natural resources (SDA) in the environment in video form. The method of development used in this development is the 4d method, consisting of the defining, design, development, and dissemination stages. Using this learning medium can be a relevant solution for teachers to communicate the science learning material for fourth graders.
Keyword: Project Motion, Learning Material, Natural Sciences, Elemantary School
Pengaruh Model Pembelajaran Problem Based Learning Berbantuan Media Mobile Learning Terhadap Kemampuan Kolaborasi Matematika Siswa Kelas IV SD
Authors: Wati Marda 
Published: October 2022

Abstrak
Penelitian ini bertujuan untuk mengetahui perbedaan kemampuan kolaborasi matematika antara siswa yang mengikuti model pembelajaran problem-based learning berbantuan media mobile learning dengan model pembelajaran discovery learning berbantuan media visual. Jenis penelitian yang digunakan adalah penelitian quasy ekperimental design type nonequivalent control group design. Populasi dalam penelitian ini adalah seluruh siswa kelas IV SD Negeri Kelurahan Lembang-lembang yang terdiri dari 5 sekolah dengan jumlah keseluruhan siswa adalah 137 dan sampel penelitian adalah siswa kelas IV SDN 010 Palece dan SDN 008 Camba-camba, berjumlah 58 orang dengan teknik pengambilan sampel cluster random sampling. Teknik pengumpulan data menggunakan lembar observasi ditinjau dari indikator kemampuan kolanborasi yang dianalisis secara deskriptif. Berdasarkan hasil analisis Uji Paired-Sampel T-Test, diperoleh nilai Sig 0,001 < 0,05. Karena nilai signifikan lebih kecil dari pada 0,05 maka dapat disimpulkan ada perbedaan kemampuan kolaborasi matematika siswa kelas IV SD antara siswa yang diajar model pembelajaran problem-based learning berbantuan media mobile learning dengan model pembelajaran discovery learning berbantuan media visual
Minimally invasive procedures for hypothalamic hamartoma–related epilepsy: a systematic review and meta-analysis
Authors: Iranmehr Arad , Dabbagh Ohadi Mohammad Amin , Chavoshi Mohammadreza , Jahanbakhshi Amin , Slavin Konstantin V. 
Published: October 2022

OBJECTIVE
Hypothalamic hamartoma (HH) is a rare, nonmalignant, heterotopic developmental malformation that consists of a mixture of normal neurons and glial cells. Resection of HHs has been associated with high rates of mortality and morbidity. Therefore, minimally invasive ablation methods could be the best treatment option for HH. The most frequently used minimally invasive options for HH ablation are radiofrequency thermocoagulation (RFT), laser ablation (LA), and stereotactic radiosurgery.

METHODS
To investigate three minimally invasive procedures in the treatment of refractory seizures related to HH, the authors conducted a systematic search in March 2022 in the MEDLINE, Embase, Scopus, and Web of Science databases in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Seizure freedom was the primary outcome of interest. The authors defined seizure freedom as Engel class I or International League Against Epilepsy class 1 or 2 or as the reported term “seizure freedom.” The secondary outcome was long-term complications reported in studies. Both random- and fixed-effects models were used to calculate the pooled proportion of seizure freedom and complication rate with 95% confidence intervals. A modified version of the Joanna Briggs Institute (JBI) Critical Appraisal to assess the risk of bias was used.

RESULTS
The authors included 15 studies with 422 patients (RFT, n = 190; LA, n = 171; and Gamma Knife Radiosurgery [GKRS], n = 61). Generally, the mean incidences of overall seizure freedom after minimally invasive procedures were 77% (95% CI 0.74–0.81) and 68% (95% CI 0.57–0.79) using fixed- and random-effects models, respectively. The mean incidence of overall seizure freedom after RFT was 69% (95% CI 0.63–0.75), and the mean incidences of overall seizure freedom after LA and GKRS were 87% (95% CI 0.82–0.92) and 44% (95% CI 0.32–0.57), respectively. The total complication rate with minimally invasive procedures was 13% (95% CI 0.01–0.26). The complication rate in each treatment was as follows: 5% (95% CI 0.0–0.12) for RFT, 20% (95% CI 0.0–0.47) for LA, and 22% (95% CI 0–0.65) for GKRS. Meta-regression analysis showed an association between older age and higher complication rates in the LA group.

CONCLUSIONS
In this meta-analysis, LA showed superiority in seizure freedom over the other two methods. The complication rate associated with RFT was less than those in the other two methods; however, this difference was not statistically significant.
Comparison of outcomes after stereoelectroencephalography and subdural grid monitoring in pediatric tuberous sclerosis complex
Authors: Larrew Thomas , Skoch Jesse , Ihnen S. Katie Z. , Arya Ravindra , Holland Katherine D. , Tenney Jeffrey R. , Horn Paul S. , Leach James L. , Krueger Darcy A. , Greiner Hansel M. , Mangano Francesco T. 
Published: October 2022

OBJECTIVE
Patients with tuberous sclerosis complex (TSC) epilepsy present with unique clinical challenges such as early seizure onset and high rates of intractability and multifocality. Although there are numerous studies about the safety and efficacy of stereoelectroencephalography (SEEG), this topic has not been studied in TSC patients who have distinct epilepsy profiles. The authors investigated subdural grid (SDG) and SEEG monitoring to determine whether these procedures lead to similar seizure and safety outcomes and to identify features unique to this pediatric population.

METHODS
TSC patients who underwent SDG or SEEG placement and a second epilepsy surgery during the period from 2007 to 2021 were included in this single-center retrospective cohort analysis. Various patient, hospitalization, and epilepsy characteristics were collected.

RESULTS
A total of 50 TSC patients were included in this study: 30 were included in the SDG cohort and 20 in the SEEG cohort. Baseline weekly seizure count did not significantly differ between the 2 groups (p = 0.412). The SEEG group had a greater mean baseline number of antiepileptic drugs (AEDs) (3.0 vs 2.0, p = 0.003), higher rate of previous surgical interventions (25% vs 0%, p = 0.007), and larger proportion of patients who underwent bilateral monitoring (50% vs 13.3%, p = 0.005). Despite this, there was no significant difference in seizure freedom between the SDG and SEEG cohorts. The mean reduction in seizure count was 84.9% and 47.8% of patients were seizure free at last follow-up (mean 79.4 months). SEEG trended toward being a safer procedure than SDG monitoring, with a shorter mean ICU stay (0.7 days vs 3.9 days, p < 0.001), lower blood transfusion rate (0% vs 13.3%, p = 0.140), and lower surgical complication rate (0% vs 10%, p = 0.265).

CONCLUSIONS
In the comparison of the SDG and SEEG cohorts, the SEEG group included patients who appeared to receive more aggressive management and have a higher rate of multifocality, more prior surgical interventions, more AEDs at baseline, and a higher rate of bilateral invasive monitoring. Despite this, the SEEG cohort had similar seizure outcomes and a trend toward increased safety. Based on these findings, SEEG appears to allow for monitoring of a wider breadth of TSC patients given its minimally invasive nature and its relative simplicity for monitoring numerous regions of the brain.
Racial and socioeconomic disparities in the advanced treatment of medically intractable pediatric epilepsy
Authors: Kandregula Sandeep , Terrell Danielle , Beyl Robbie , Freelin Anne , Guthikonda Bharat , Notarianni Christina , Toms Jamie 
Published: October 2022

OBJECTIVE
Racial and ethnic disparities in healthcare have gained significant importance since the Institute of Medicine published its report on disparities in healthcare. There is a lack of evidence on how race and ethnicity affect access to advanced treatment of pediatric medically intractable epilepsy. In this context, the authors analyzed the latest Kids’ Inpatient Database (KID) for racial/ethnic disparities in access to surgical treatment of epilepsy.

METHODS
The authors queried the KID for the years 2016 and 2019 for the diagnosis of medically intractable epilepsy.

RESULTS
A total of 29,292 patients were included in the sample. Of these patients, 8.9% (n = 2610) underwent surgical treatment/invasive monitoring. The mean ages in the surgical treatment and nonsurgical treatment groups were 11.73 years (SD 5.75 years) and 9.5 years (SD 6.16 years), respectively. The most common insurance in the surgical group was private/commercial (55.9%) and Medicaid in the nonsurgical group (47.7%) (p < 0.001). White patients accounted for the most common population in both groups, followed by Hispanic patients. African American patients made up 7.9% in the surgical treatment group compared with 12.9% in the nonsurgical group. African American (41.1%) and Hispanic (29.9%) patients had higher rates of emergency department (ED) utilization compared with the White population (24.6%). After adjusting for all covariates, the odds of surgical treatment increased with increasing age (OR 1.06, 95% CI 1.053–1.067; p < 0.001). African American race (OR 0.513, 95% CI 0.443–0.605; p < 0.001), Hispanic ethnicity (OR 0.681, 95% CI 0.612–0.758; p < 0.001), and other races (OR 0.789, 95% CI 0.689–0.903; p = 0.006) had lower surgical treatment odds compared with the White population. Medicaid/Medicare was associated with lower surgical treatment odds than private/commercial insurance (OR 0.603, 0.554–0.657; p < 0.001). Interaction analysis revealed that African American (OR 0.708, 95% CI 0.569–0.880; p = 0.001) and Hispanic (OR 0.671, 95% CI 0.556–0.809; p < 0.001) populations with private insurance had lower surgical treatment odds than White populations with private insurance. Similarly, African American patients, Hispanic patients, and patients of other races with nonprivate insurance also had lower surgical treatment odds than their White counterparts after adjusting for all other covariates.

CONCLUSIONS
Based on the KID, African American and Hispanic populations had lower surgical treatment rates than their White counterparts, with higher utilization of the ED for pediatric medically intractable epilepsy.
Responsive neurostimulation in pediatric patients with drug-resistant epilepsy
Authors: Falls Nicole , Arango Jorge I. , Adelson P. David 
Published: October 2022

OBJECTIVE
Medically refractory epilepsy remains a therapeutic challenge when resective surgery is not a practical option and indirect neurostimulation efficacy may be limited. In these instances responsive neurostimulation (RNS) has been used in adults, with good outcomes in most patients. However, the utility of RNS in children and young adults has not been systematically explored. In this study, the authors present a single institution’s experience with RNS in pediatric patients.

METHODS
A single-center retrospective chart review of patients who underwent RNS implantation at Phoenix Children’s Hospital during the 4-year period between January 2018 and December 2021 was performed.

RESULTS
Following evaluation for epilepsy surgery, 22 patients underwent RNS implantation using different anatomical targets depending on the predetermined epileptic focus/network. In the cohort, 59% of patients were male, the mean age at implantation was 16.4 years (range 6–22 years), and the mean follow-up time was 2.7 years (range 1.0–4.3 years). All patients had a preoperative noninvasive evaluation that included MRI, video-electroencephalography, and resting-state functional MRI. Additionally, 13 patients underwent invasive monitoring with stereo-electroencephalography to help determine RNS targets. All patients had variable positive responses with reduction of seizure frequency and/or intensity. Overall, seizure frequency reduction of > 50% was seen in the majority (86%) of patients. There were two complications: one patient experienced transitory weakness and one generator failed, requiring replacement. A patient died of sudden unexpected death in epilepsy 3 years after implantation despite being seizure free during the previous year.

CONCLUSIONS
RNS used in children with medically refractory epilepsy improved seizure control after implantation, with decreases in seizure frequency > 50% from preoperative baseline in the majority of patients. Preliminary findings indicate that functional MRI and stereo-electroencephalography were helpful for RNS targeting and that RNS can be used safely even in young children.
Preoperative MRI for postoperative seizure prediction: a radiomics study of dysembryoplastic neuroepithelial tumor and a systematic review
Authors: Wang Jun , Luo Xinyi , Chen Chenghan , Deng Jiahong , Long Hao , Yang Kaijun , Qi Songtao 
Published: October 2022

OBJECTIVE
In this systematic review the authors aimed to evaluate the effectiveness and superiority of radiomics in detecting tiny epilepsy lesions and to conduct original research in the use of radiomics for preliminary prediction of postoperative seizures in patients with dysembryoplastic neuroepithelial tumor (DNET).

METHODS
The PubMed and Web of Science databases were searched from the earliest record, January 1, 2018, to December 29, 2021, for reports of the detection of epilepsy using radiomics, and the resulting articles were carefully checked according to the PRISMA 2020 guidelines. The authors then conducted original research by evaluating MR images in 18 patients, who were then separated into two groups, the epilepsy recurrence group (ERG) and the epilepsy nonrecurrence group. The tumor region and the edema region were segmented manually by 3D Slicer. The radiomics data were extracted from MR images by using “Slicer Radiomics” running on Mac OS X. Tumor regions were observed with T1-weighted imaging, and edema with FLAIR imaging. Radiomics features with significant differences were selected through comparison according to epilepsy relapses performed with the Mann-Whitney U-test. The edema and tumor regions were also compared within groups to identify their distinctive features. Radiomics features were tested to verify their ability to predict recurrence epilepsy by receiver operating characteristic curve.

RESULTS
This systematic review located 9 original articles related to epilepsy and radiomics published from 2018 to 2021. The reported studies demonstrated that radiomics is useful for detecting tiny epilepsy lesions. Among the radiomics features used, the predictive ability of the area under the curve was more than 0.8. The heterogeneity of the peritumoral edema region was found to be higher in the ERG.

CONCLUSIONS
Satellite lesions in the peritumoral edema region of DNET patients may cause epilepsy recurrence, and radiomics is an emerging method to detect and evaluate these epilepsy-associated lesions.
Subdural electrodes versus stereoelectroencephalography for pediatric epileptogenic zone localization: a retrospective cohort study
Authors: Remick Madison , Akwayena Emefa , Harford Emily , Chilukuri Akanksha , White Gretchen E. , Abel Taylor J. 
Published: October 2022

OBJECTIVE
The objective of this study was to compare the relative safety and effectiveness of invasive monitoring with subdural electrodes (SDEs) and stereoelectroencephalography (sEEG) in pediatric patients with drug-resistant epilepsy.

METHODS
A retrospective cohort study was performed in 176 patients who underwent invasive monitoring evaluations at UPMC Children’s Hospital of Pittsburgh between January 2000 and September 2021. To examine differences between SDE and sEEG groups, independent-samples t-tests for continuous variables and Pearson chi-square tests for categorical variables were performed. A p value < 0.1 was considered statistically significant.

RESULTS
There were 134 patients (76%) in the SDE group and 42 (24%) in the sEEG group. There was a difference in the proportion with complications (17.9% in the SDE group vs 7.1% in the sEEG group, p = 0.09) and resection (75.4% SDE vs 21.4% sEEG, p < 0.01) between SDE and sEEG patients. However, there was no observable difference in the rates of postresection seizure freedom at 1-year clinical follow-up (60.2% SDE vs 75.0% sEEG, p = 0.55).

CONCLUSIONS
These findings reveal a difference in rates of surgical complications and resection between SDEs and sEEG. Larger prospective, multi-institutional pediatric comparative effectiveness studies may further explore these associations.
Implementasi Sistem Struktur Soko Guru pada Masjid Berkubah Beton
Authors: Kusyanto Mohhamad , Sofyan Afriyanto , Koesmartadi Cristophorus 
Published: October 2022

Pengembangan masjid sebagai tempat ibadah untuk menampung jamaah yang lebih banyak dan mengikuti perkembangan teknologi mendasari masyarakat membangun masjid berkubah yang megah dengan konstruksi beton. Struktur soko guru dipertahankan untuk menopang beban kubah beton masjid. Keterbatasan pendanaan dan pengetahuan memunculkan permasalahan dalam implementasi sistem struktur soko guru yang digunakan dalam bangunan masjid. Artikel ini bertujuan untuk memberikan gambaran pengetahuan implementasi sistem struktur soko guru dalam kaitannya dengan sistem struktur lain pada masjid berkubah beton. Metode penelitian dengan kualitatif dengan pendekatan studi kasus pada salah satu masjid berkubah beton. Metode pengumpulan data dengan survei dan wawancara kepada panitia pembangunan. Analisis sistem struktur meliputi kolom, balok (balok induk dan balok anak), joint kolom-balok, dan balok kubah pada masjid. Analisis perbandingan dimensi balok dan kolom dengan menggunakan panduan rumus kaidah praktis serta dikuatkan dengan analisis momen dan cek desain struktur dengan menggunakan software ETABS versi 9.6. Hasil penelitian menunjukkan adanya implementasi sistem struktur soko guru penopang kubah yang dapat menimbulkan beban tekuk (buckling) tanpa perkuatan balok terhadap kolom. Balok kantilever yang menopang balok kubah tanpa pengaku/bracing rentan terhadap retak dan patah pada sistem struktur tersebut. Kombinasi sistem struktur balok kantilever dan soko guru secara keseluruhan lebih aman sistem strukturnya.
Identifying the Language Requirements of English for Tourism at Toraja Christian University of Indonesia
Authors: Sallata Yizrel Nani , Arrang Judith Ratu Tandi , Siumarlata Viktor , Tandikombong Matius 
Published: October 2022

The purpose of this study is to identify the language requirements associated with English for Tourism. The respondent of the current research were Students in the sixth semester of the English Department at UKI Toraja who have recently completed the English for Tourism course. The researcher employed accidental sampling. Data were collected through interviews. The results of this research show that the language requirements needed in learning English for Tourism pertain to: Tourism knowledge, Accommodation, Culinary Tour [ pa’piong (meat cooked in bamboo), Torajan Culture [tradition, music, and art] tradition: rambutuka’ (wedding party) and rambu solo’ (funeral ceremony)., art: Ma’badong ( Traditional dance), pompang ( Traditional music). This suggests that the topic for the English for Tourism course should be developed through Torajan culture.