bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fluid Field Modulation in Mass Transfer for Efficient Photocatalysis
Authors: Dai Baoying , Zhou Yihao , Xiao Xiao , Chen Yukai , Guo Jiahao , Gao Chenchen , Xie Yannan , Chen Jun 
Published: August 2022

AbstractMass transfer is an essential factor determining photocatalytic performance, which can be modulated by fluid field via manipulating the kinetic characteristics of photocatalysts and photocatalytic intermediates. Past decades have witnessed the efforts and achievements made in manipulating mass transfer based on photocatalyst structure and composition design, and thus, a critical survey that scrutinizes the recent progress in this topic is urgently necessitated. This review examines the basic principles of how mass transfer behavior impacts photocatalytic activity accompanying with the discussion on theoretical simulation calculation including fluid flow speed and pattern. Meanwhile, newly emerged viable photocatalytic micro/nanomotors with self‐thermophoresis, self‐diffusiophoresis, and bubble‐propulsion mechanisms as well as magnet‐actuated photocatalytic artificial cilia for facilitating mass transfer will be covered. Furthermore, their applications in photocatalytic hydrogen evolution, carbon dioxide reduction, organic pollution degradation, bacteria disinfection and so forth are scrutinized. Finally, a brief summary and future outlook are presented, providing a viable guideline to those working in photocatalysis, mass transfer, and other related fields.
Long‐Life Sulfide All‐Solid‐State Battery Enabled by Substrate‐Modulated Dry‐Process Binder
Authors: Li Yongxing , Wu Yujing , Ma Tenghuan , Wang Zhixuan , Gao Qifa , Xu Jieru , Chen Liquan , Li Hong , Wu Fan 
Published: August 2022

AbstractSulfide all‐solid‐state batteries (ASSBs) have been widely acknowledged as next‐generation energy‐storage devices due to their improved safety performance and potentially high energy density. Among the various fabrication methods of sulfide ASSBs, solvent‐free dry‐film processes have unique advantages including reduced costs, suppressed film delamination, thick electrodes, and high compatibility with sulfide solid electrolytes (SEs). However, the currently dominating binder for dry‐film process polytetrafluoroethylene suffers from poor voltage stability and low viscosity, which leads to low Coulombic efficiency and poor cycling stability of sulfide ASSBs. Herein, a specially‐designed treatment is developed to obtain a new type of dry binder, styrene‐butadiene rubber (SBR), exploiting paraxylene and a NaCl substrate to dissolve and re‐precipitate SBR for controlling its stacking state, micro‐structure/morphology, density, and dispersion performance. The SE membrane prepared using this processed SBR exhibits ultra‐high ionic conductivity (2.34 mS cm‐1), contributing to excellent cycle stability of the corresponding sulfide ASSB (>84% capacity retention after 600 cycles at 0.3C).
Ponatinib after failure of second‐generation tyrosine kinase inhibitor in resistant chronic‐phase chronic myeloid leukemia
Authors: Kantarjian Hagop M. , Jabbour Elias , Deininger Michael , Abruzzese Elisabetta , Apperley Jane , Cortes Jorge , Chuah Charles , DeAngelo Daniel J. , DiPersio John , Hochhaus Andreas , Lipton Jeffrey , Nicolini Franck E. , Pinilla‐Ibarz Javier , Rea Delphine , Rosti Gianantonio , Rousselot Philippe , Shah Neil P. , Talpaz Moshe , Srivastava Shouryadeep , Ren Xiaowei , Mauro Michael 
Published: August 2022

AbstractPonatinib, the only third‐generation pan‐BCR::ABL1 inhibitor with activity against all known BCR::ABL1 mutations including T315I, has demonstrated deep and durable responses in patients with chronic‐phase chronic myeloid leukemia (CP‐CML) resistant to prior second‐generation (2G) TKI treatment. We present efficacy and safety outcomes from the Ponatinib Philadelphia chromosome–positive acute lymphoblastic leukemia (Ph+ ALL) and CML Evaluation (PACE) and Optimizing Ponatinib Treatment in CP‐CML (OPTIC) trials for this patient population. PACE (NCT01207440) evaluated ponatinib 45 mg/day in CML patients with resistance to prior TKI or T315I. In OPTIC (NCT02467270), patients with CP‐CML and resistance to ≥2 prior TKIs or T315I receiving 45 or 30 mg/day reduced their doses to 15 mg/day upon achieving ≤1% BCR::ABL1IS or received 15 mg/day continuously. Efficacy and safety outcomes from patients with CP‐CML treated with ≥1 2G TKI (PACE, n = 257) and OPTIC (n = 93), 45‐mg starting dose cohort, were analyzed for BCR::ABL1IS response rates, overall survival (OS), progression‐free survival (PFS), and safety. By 24 months, the percentages of patients with ≤1% BCR::ABL1IS response, PFS, and OS were 46%, 68%, and 85%, respectively, in PACE and 57%, 80%, and 91%, respectively, in OPTIC. Serious treatment‐emergent adverse events and serious treatment‐emergent arterial occlusive event rates were 63% and 18% in PACE and 34% and 4% in OPTIC. Ponatinib shows high response rates and robust survival outcomes in patients whose disease failed prior to 2G TKIs, including patients with T315I mutation. The response‐based dosing in OPTIC led to improved safety and similar efficacy outcomes compared with PACE.
Assessing co‐occurring mental health conditions in a multidisciplinary Down syndrome clinic and the role of family history
Authors: Raffaele Gabriella , Blout Zawatsky Carrie L. , Cottrell Clorinda , Santoro Stephanie L. 
Published: August 2022

AbstractCompared to the general population, individuals with Down syndrome (DS) are at a significantly increased risk to develop mental health conditions. This study sought to examine individuals with DS and co‐existing mental health comorbidities at one DS specialty clinic. Retrospective chart review of medical records including demographics, genetic testing history, personal and familial mental health history, referrals for mental health indications, and recommendations was performed. Summary statistics, logistic regression, and log of odds were converted to odd ratios to assess associations and significance. The charts of 327 patients, average 19.4 years of age (1–70), were reviewed. Nearly half the participants (42.2%) had at least one diagnosis of a mental health condition. Those with a family history were significantly more likely to have a personal diagnosis of a mental health condition than those without a family history (p < 0.01). Moreover, those who completed referrals often received medical management recommendations (86%). This study highlights the prevalence of mental health comorbidities among individuals with DS, and the referral process for mental health conditions, at one DS specialty clinic. Further research is needed to investigate our family history findings, and to determine if these results are generalizable across other DS clinics.
CELSR1 variants are associated with partial epilepsy of childhood
Authors: Chen Zheng , Luo Sheng , Liu Zhi‐Gang , Deng Yan‐Chun , He Su‐Li , Liu Xiao‐Rong , Yi Yong‐Hong , Wang Jie , Gao Liang‐Di , Li Bing‐Mei , Wu Zhi‐Jun , Ye Zi‐Long , Liang De‐Hai , Bian Wen‐Jun , Liao Wei‐Ping ,   For the China Epilepsy Gene 1.0 Project
Published: August 2022

AbstractCELSR1 gene, encoding cadherin EGF LAG seven‐pass G‐type receptor 1, is mainly expressed in neural stem cells during the embryonic period. It plays an important role in neurodevelopment. However, the relationship between CELSR1 and disease of the central nervous system has not been defined. In this study, we performed trios‐based whole‐exome sequencing in a cohort of 356 unrelated cases with partial epilepsy without acquired causes and identified CELSR1 variants in six unrelated cases. The variants included one de novo heterozygous nonsense variant, one de novo heterozygous missense variant, and four compound heterozygous missense variants that had one variant was located in the extracellular region and the other in the cytoplasm. The patients with biallelic variants presented severe epileptic phenotypes, whereas those with heterozygous variants were associated with a mild epileptic phenotype of benign epilepsy with centrotemporal spikes (BECTS). These variants had no or low allele frequency in the gnomAD database. The frequencies of the CELSR1 variants in this cohort were significantly higher than those in the control populations. The evidence from ClinGen Clinical‐Validity Framework suggested a strong association between CELSR1 variants and epilepsy. These findings provide evidence that CELSR1 is potentially a candidate pathogenic gene of partial epilepsy of childhood.
Design Strategies for Responsive Fluorine‐19 Magnetic Resonance Probes Using Paramagnetic Metal Complexes
Authors: Ryan Raphael T. , Scott Kathleen M. , Que Emily L. 
Published: August 2022

AbstractMagnetic resonance imaging (MRI) is a powerful and widely used in vivo imaging technique that enables whole body imaging without ionizing radiation. In clinical practice, 1H MRI is employed for imaging anatomical and physiological states via monitoring of protons in water and lipids. In order to monitor biochemical processes at the molecular level, several research groups are exploring responsive MRI agents that alter their signal upon interaction with an analyte or biological environment of interest. Fluorine (19F) MRI agents are promising due to the 19F nucleus having similar magnetic resonance (MR) properties to proton and the absence of endogenous 19F in living systems, resulting in no background signal. In order to make responsive 19F MR agents for molecular imaging and analysis, fluorinated platforms must be developed in which their 19F MR signal changes after interacting with a target analyte. A promising strategy is to use paramagnetic metals to modulate the 19F MR signal by altering the relaxation rates and/or chemical shift of an appended 19F imaging tag. In this concept, we provide an overview of the theoretical principles and molecular design strategies that have been exploited in the design of responsive 19F MR agents, with a specific focus on agents based on small molecule paramagnetic metal ion chelates.
Measurement of Protein Dynamics from Site Directed Cu(II) Labeling
Authors: Singewald Kevin , Hunter Hannah , Cunningham Timothy F. , Ruthstein Sharon , Saxena Sunil 
Published: August 2022

AbstractThis review describes the use of Electron Paramagnetic Resonance (EPR) to measure residue specific dynamics in proteins with a specific focus on Cu(II)‐based spin labels. First, we outline approaches used to measure protein motion by nitroxide‐based spin labels. Here, we describe conceptual details and outline challenges that limit the use of nitroxide spin labels to solvent‐exposed α‐helical sites. The bulk of this review showcases the use of newly developed Cu(II)‐based protein labels. In this approach, the strategic mutation of native residues on a protein to generate two neighboring Histidine residues (i.e., the dHis motif) is exploited to enable a rigid site‐selective binding of a Cu(II) complex. The chelation of the Cu(II) complex to dHis directly anchors the Cu(II) spin label to the protein backbone. The improvement in rigidity expands both the spin‐labeling toolkit as well as the resolution of many EPR measurements. We describe how EPR measurements of the Cu(II) label directly reflect backbone motion and fluctuations. The EPR are complemented by Molecular Dynamics simulations. Finally, the dHis motif provides access to the measurement of site‐specific dynamics at both α‐helices and β‐sheets. The review outlines the limitations of the dHis method and provides an outlook for future developments.
Composition and process approaches that underpin the mechanical properties of oleogels
Authors: Barroso Noádia Genuario , Santos Matheus Augusto Silva , Okuro Paula Kiyomi , Cunha Rosiane Lopes 
Published: August 2022

AbstractConsumers are becoming aware of the relevance of eating low levels of trans and saturated fats in processed foods. In addition, many countries are adopting regulatory measures on the use of these ingredients. For this reason, the exploration of new technologies capable of producing structures that trap liquid oil (composed mainly of unsaturated fatty acids, which are considered healthier) has been widely investigated to replace saturated and trans fats in food products. One of the most promising technologies is the so‐called oleogels, which present a great challenge to mimic sensory attributes related to the texture of processed foods based on saturated fats. In this review, we discuss the influence of the production methods (direct or indirect) and composition of the oleogels on their mechanical properties that are related to the texture. An overview of the parameters that can interfere with these properties contributes to a better understanding of the building of the oleogels and their possible applications.
Synthesis of low‐costing 4A‐zeolite and stabilization of heavy metals from municipal solid waste incineration fly ash and activated red mud
Authors: Ma Wenjun , Liang Zhiyuan , Liu Mengshun , Xu Zhiwen , Zhao Qinxin 
Published: August 2022

AbstractTo handle the increasing environmental issues caused by red mud and municipal solid waste incineration (MSWI) fly ash, an integrated technology for its comprehensive utilization was developed through the activation of red mud followed by synthesis of 4A‐zeolite. Three influencing factors on the thermal‐alkali activation effect of red mud were investigated. Afterwards, activated red mud was combined with fly ash to synthesize 4A‐zeolite and solidify heavy metal simultaneously. The results indicated that the maximum extraction ratios of Si (57.77%) and Al (76.34%) from red mud were achieved at the NaOH/red mud mass ratio of 1.8, alkali fusion temperature of 800°C, and alkali fusion time of 120 min. Furthermore, the mixture of activated red mud and MSWI fly ash could be served as low‐costing raw materials to synthesize zeolite products with a compact structure. The solidification effect of typical heavy metals could meet GB 16889–2008 and HJ/300–2007 completely. Especially, the solidification efficiency for Cu, Zn, Pb, and Cd could reach 98.23%, 99.09%, 99.72%, and 98.21%, respectively. This paper not only solved the red mud accumulation and heavy metal pollution caused by fly ash under a relatively low‐temperature environment but also synthesized zeolite products containing huge economic benefits.
High‐performance electric heating yarns based on graphene‐coated cotton fibers
Authors: Wu Bo , Liu Yu , Yu Hong 
Published: August 2022

AbstractGraphene and graphene‐based materials can emit far‐infrared light with a wavelength of 6–14 μm that are beneficial to the human body when subjected low voltage, which have attracted much attention. However, the most previously reported heating devices based on graphene materials are thin films; therefore, there are a series of problems such as poor air permeability, difficulty in integration with clothing, and uncomfortable wearing. In this work, a simple ultrasonic dip‐coating method is used to prepare the electric heating yarns based on graphene‐coated cotton fibers, where the high‐performance hybrid yarns can be driven at a safe voltage. The number of ultrasonic dip‐coating and the linear density of the yarns have shown the great influence on electric heating performance. After three ultrasonic dip‐coatings, the temperature of the hybrid yarn with 3.5 mm diameter and 10 cm length can reach ~70°C at a voltage of 20 V, while the heating power is only ~2.5 W. Our studies have demonstrated the potential of hybrid yarns which can be used in the field of heating clothing or medical care.
Identifying the landscape of developmental toxicity new approach methodologies
Authors: Becker Richard A. , Bianchi Enrica , LaRocca Jessica , Marty Mary Sue , Mehta Vatsal 
Published: August 2022

AbstractBackgroundThe dynamics and complexities of in utero fetal development create significant challenges in transitioning from lab animal‐centric developmental toxicity testing methods to assessment strategies based on new approach methodologies (NAMs). Nevertheless, considerable progress is being made, stimulated by increased research investments and scientific advances, such as induced pluripotent stem cell‐derived models. To help identify developmental toxicity NAMs for toxicity screening and potential funding through the American Chemistry Council's Long‐Range Research Initiative, a systematic literature review was conducted to better understand the current landscape of developmental toxicity NAMs.MethodsScoping review tools were used to systematically survey the literature (2010–2021; ~18,000 references identified), results and metadata were then extracted, and a user‐friendly interactive dashboard was created.ResultsThe data visualization dashboard, developed using Tableau® software, is provided as a free, open‐access web tool. This dashboard enables straightforward interactive queries and visualizations to identify trends and to distinguish and understand areas or NAMs where research has been most, or least focused.ConclusionsHerein, we describe the approach and methods used, summarize the benefits and challenges of applying the systematic‐review techniques, and highlight the types of questions and answers for which the dashboard can be used to explore the many different facets of developmental toxicity NAMs.
Green manufacturing for sustainable development: The positive effects of green activities, green investments, and non‐green products on economic performance
Authors: D'Angelo Viviana , Cappa Francesco , Peruffo Enzo 
Published: August 2022

AbstractThis article explores the impact of green manufacturing practices, disentangled in green activities, green investments, and the type of product made, on the economic performance of firms. Using survey data collected by European Commission from European small‐ and medium‐sized enterprises (SMEs), we adopt the self‐determination theory to investigate the extent to which the number of green activities, green investments, and type of product made affects a firm's economic performance. We argue that consumers are affected by firms' green manufacturing practices in response to the pressing environmental issues affecting our era. Our results reveal that while the number of green activities has a positive effect on economic performance, the amount of green manufacturing investments has an inverted U‐shaped relationship to economic performance and that this effect is positively moderated if a company also sells non‐green products. Our study contributes to the literature on green manufacturing by dissecting the effect of green manufacturing practices on a company's economic performance. Our findings also provide managers with advice on the right balance of green practices that most benefit their companies.
Porous Heteroatom‐Doped Carbons: Efficient Catalysts for Selective Oxidation of Alcohols by Activated Persulfate
Authors: Oliveira Rafael L. , Nicinski Krzysztof , Pisarek Marcin , Kaminska Agnieszka , Thomas Arne , Pasternak Grzegorz , Colmenares Juan C. 
Published: August 2022

AbstractAldehydes are essential chemicals for industrial feedstock. However, the traditional processes to produce these chemicals face many limitations, such as waste generation, low selectivity, or high cost. Herein, we report the synthesis and characterization of a group of porous heteroatom (P, B or N)‐doped carbons and their use as catalysts for the oxidation of primary alcohols by activating peroxydisulfate. Among the heteroatom‐doped carbons, porous N‐doped carbons pyrolyzed at 700 or 800 °C show the highest activity. Experimental studies were performed suggesting a considerable contribution of a non‐radical oxidation process. Furthermore, N‐doped carbons can act as a catalyst in the oxidation of a large substrate scope of substituted alcohols.
Simulation of Droplet Formation in T‐Inlet Microchannels with Different Junction Angle
Authors: Yang Qingjun , Cao Wang , Mao Qi 
Published: August 2022

AbstractThe level set method was used to numerically simulate the droplet formation process in T‐junction microchannels with different junction angle. The effects of flow rate ratio, capillary number, and contact angle on droplet formation under different junction angles were discussed. The numerical simulation results show that the dimensionless length and generation frequency of microdroplets increase with the flow rate ratio. It was observed that the droplet transforms from the squeezing regime to the dripping regime when the capillary number Ca is ≥ 0.02. For Ca ≤ 0.04, the smallest droplet was generated in the microchannel with 120° junction angle. Finally, the results also indicate that the effect of the contact angle is discrepant at different junction angles.
Previous SARS‐CoV‐2 infection or a third dose of vaccine elicited cross‐variant neutralising antibodies in vaccinated solid‐organ transplant recipients
Authors: Chang Chih‐Chao , Vlad George , Vasilescu Elena Rodica , Li Ping , Husain Syed A , Silvia Elaine A , Cohen David J , Ratner Lloyd E , Sun Wei‐Zen , Mohan Sumit , Suciu‐Foca Nicole 
Published: August 2022

AbstractObjectivesThe SARS‐CoV‐2 pandemic poses a great threat to global health, particularly in solid organ transplant recipients (SOTRs). A 3‐dose mRNA vaccination protocol has been implemented for the majority of SOTRs, yet their immune responses are less effective compared to healthy controls (HCs).MethodsWe analyzed the humoral immune responses against the vaccine strain and variants of concern (VOC), including the highly mutated‐omicron variant in 113 SOTRs, of whom 44 had recovered from COVID‐19 (recovered‐SOTRs) and 69 had not contracted the virus (COVID‐naïve). In addition, 30 HCs, 8 of whom had recovered from COVID‐19, were also studied.ResultsHere, we report that three doses of the mRNA vaccine had only a modest effect in eliciting anti‐viral antibodies against all viral strains in the fully vaccinated COVID‐naive SOTRs (n = 47). Only 34.0% of this group of patients demonstrated both detectable anti‐RBD IgG with neutralization activities against alpha, beta, and delta variants, and only 8.5% of them showed additional omicron neutralizing capacities. In contrast, 79.5% of the recovered‐SOTRs who received two doses of vaccine demonstrated both higher anti‐RBD IgG levels and neutralizing activities against all VOC, including omicron.ConclusionThese findings illustrate a significant impact of previous infection on the development of anti‐SARS‐CoV‐2 immune responses in vaccinated SOTRs and highlight the need for alternative strategies to protect a subset of a lesser‐vaccine responsive population.
Disorder or a new order: How climate change affects phenological variability
Authors: Stemkovski Michael , Bell James R. , Ellwood Elizabeth R. , Inouye Brian D. , Kobori Hiromi , Lee Sang Don , Lloyd‐Evans Trevor , Primack Richard B. , Templ Barbara , Pearse William D. 
Published: August 2022

AbstractAdvancing spring phenology is a well documented consequence of anthropogenic climate change, but it is not well understood how climate change will affect the variability of phenology year to year. Species' phenological timings reflect the adaptation to a broad suite of abiotic needs (e.g., thermal energy) and biotic interactions (e.g., predation and pollination), and changes in patterns of variability may disrupt those adaptations and interactions. Here, we present a geographically and taxonomically broad analysis of phenological shifts, temperature sensitivity, and changes in interannual variability encompassing nearly 10,000 long‐term phenology time series representing more than 1000 species across much of the Northern Hemisphere. We show that the timings of leaf‐out, flowering, insect first‐occurrence, and bird arrival were the most sensitive to temperature variation and have advanced at the fastest pace for early‐season species in colder and less seasonal regions. We did not find evidence for changing variability in warmer years in any phenophase groups, although leaf‐out and flower phenology have become moderately but significantly less variable over time. Our findings suggest that climate change has not to this point fundamentally altered the patterns of interannual phenological variability.