bluuebunny/crossref_metadata_2025_split huggingface dataset:
Human Papillomavirus Infection Rate by Genotype and Vaccination Rates in Canada: Canadian Health Measures Survey 2009 to 2013
Authors: Chao Yi-Sheng 
Published: April 2022

AbstractBackgroundAn infection with certain HPV genotypes can lead to cancer or genital warts. HPV can be detected with PCR-based tests, and some genotypes can be prevented by vaccines. However, since the infection rates of various HPV genotypes have not been well reported, the present study aims to provide this information.MethodsThe Canadian Health Measures Survey (CHMS) is an ongoing biannual national survey. Between 2009 and 2011, it sampled a nationally representative sample of females aged 14 to 59 years to determine the infection rates of 46 HPV genotypes. Females aged 9 to 29 years and 9 to 59 years were asked whether they received HPV vaccines between 2009 to 2011 (cycle 2) and 2012 to 2013 (cycle 3), respectively. The reported infection rates and vaccination proportions were weighted and adjusted for the survey design.ResultsAmong the estimated 10,592,968 females aged 14 to 59 years at cycle 2, the HPV genotypes with the highest infection rates were 16, 62, 74, and 54, and the rates were 3.42% (95% CI = 1.67% to 5.17%), 2.14% (95% CI = 0.68% to 3.59%), 2.1% (95% CI = 0.51% to 3.69%), and 2.04% (95% CI = 0.38% to 3.7%), respectively. There were an estimated 6,569,100 and 11,603,752 females aged 9 to 29 and 9 to 59 years at cycles 2 and 3, respectively. The proportions receiving a HPV vaccine were 13.55% (11.18% to 15.92%) and 12.3% (9.8% to 14.79%), respectively. The estimated numbers of females that received HPV vaccines were 890,197 and 1,427,000, respectively.ConclusionCanada is one of the few countries that conduct national surveys to determine HPV infection rates by genotype, which are not limited to the surveillance of carcinogenic genotypes. Our study found discrepancies between the HPV genotypes whose infections were the most common, that could be detected by PCR tests, that were carcinogenic, and that could be prevented by vaccines. For example, 5 of the 7 genotypes (42, 54, 62, 66, and 74) with infection rates of more than 1% cannot be detected by PCR tests and are not targeted by vaccines. HPV 51 is carcinogenic, associated with genital warts, and can be detected by PCR tests, but it is not targeted by vaccines. We recommend a better alignment of the genotypes targeted by HPV tests and vaccines with those genotypes with the highest infection rates in Canada.
The HH-GLI2-CKS1B network regulates the proliferation-to-maturation transition of human cardiomyocytes
Authors: Waldron Christina J. , Kelly Lauren A. , Kawakami Yasuhiko , Abrahante Juan E. , Magli Alessandro , Ogle Brenda M. , Singh Bhairab N. 
Published: April 2022

AbstractCardiomyocyte (CM) proliferation and maturation are highly linked processes, however, the extent to which these processes are controlled by a single signaling axis is unclear. Here, we find the Hedgehog (HH)-GLI2-CKS1B cascade regulates the transition between proliferation and maturation in hiPSC-CMs. Initially, we found a significant enrichment of GLI2-signaling in CMs from patients with ischemic heart failure (HF) or dilated-cardiomyopathy (DCM), indicating initiation of fetal programs in the stressed heart. Developmentally, we showed downregulation of GLI-signaling in adult human CM, adult murine CM, and in late-stage hiPSC-CM. In early-stage, proliferative hiPSC-CM, inhibition of Hh- or GLI-proteins enhanced CM maturation. Mechanistically, we identified CKS1B, a new effector of GLI2 and showed that GLI2 binds the CKS1B promoter to regulate its expression. CKS1B overexpression in late-stage hiPSC-CMs led to increased proliferation with loss of maturation. Thus, the Hh-GLI2-CKS1B axis regulates the proliferation-maturation transition and provides targets to enhance cardiac tissue engineering and regenerative therapies.
Demographic expansions and the emergence of host specialization in genetically distinct strains of the tick-transmitted bacteriumAnaplasma phagocytophilum
Authors: Aardema Matthew L. , Bates Nina V. , Archer Qiana E. , von Loewenich Friederike D. 
Published: April 2022

ABSTRACTBacteria species that must obligately replicate in vertebrate host cells make up a large proportion of the prokaryotic pathogens with human and veterinary health implications. In such bacterial taxa, extrinsic processes play an important role in influencing the phylogenetic diversity of viable hosts (‘host range’). These processes include both changes in host population densities and shifts in host geographic distributions. In Europe, distinct genetic strains of the tick-vectored bacteriumAnaplasma phagocytophilumcirculate among mammals in three discrete enzootic cycles. To date, the factors that contributed to the emergence of these strains have been poorly studied. Here we show that the strain which predominately infects roe deer (Capreolus capreolus) is evolutionarily derived. Its divergence from a likely host-generalist ancestor occurred after the last glacial maximum as mammal populations, including roe deer, recolonized the European mainland from southern refugia. We also provide evidence that this host-specialist strain’s effective population size (Ne) has tracked changes in the population of its roe deer host. Specifically, both host and bacterium appear to have undergone substantial increases in Neover the past 1,500 years. In contrast, we show that while it appears to have undergone a major population expansion starting ∼3,500 years ago, in the past 500 years the contemporary host-generalist strain has experienced a substantial reduction in genetic diversity levels, possible as the result of reduced transmission opportunities between competent hosts.IMPORTANCEThe findings of this study are some of the first to examine specific events in the evolution of host specialization in a naturally occurring, obligately intracellular bacterial species. They show that host range shifts and the emergence of host specialization may occur during periods of population growth in a host-generalist ancestor. The results discussed here also show the close correlation between demographic patterns in host and pathogen for a specialist system. These findings have important relevance for our understanding of the evolution of host-range diversity. They may inform future work on host-range dynamics and provide insights for understanding the emergence of pathogens which have human and veterinary health implications.
Vaccine effectiveness of BNT162b2 against Omicron and Delta outcomes in adolescents
Authors: Buchan Sarah A. , Nguyen Lena , Wilson Sarah E. , Kitchen Sophie A. , Kwong Jeffrey C. 
Published: April 2022

AbstractIntroductionData on vaccine effectiveness (VE) against Omicron in adolescents are limited. We estimated 2-dose and 3-dose VE against Omicron and Delta in adolescents aged 12-17 years in Ontario, Canada.MethodsWe conducted a test-negative design study among SARS-CoV-2-tested adolescents aged 12-17 years between November 22, 2021 (date of first Omicron detection) and March 6, 2022; we assessed Delta outcomes prior to January 2, 2022. We used multivariable logistic regression to compare the odds of vaccination in cases to symptomatic test-negative controls and calculated VE as 1-adjusted odds ratio.ResultsVE was lower against symptomatic Omicron infection than against Delta and decreased more rapidly over time, from 51% (95%CI, 38-61%) in the 7-59 days following a second dose to 29% (95%CI, 17-38%) after 180 days, compared to 97% (95%CI, 94-99%) and 90% (95%CI, 79-95%) for the same intervals against symptomatic Delta infection. Overall, 2-dose VE against severe outcomes caused by Omicron was 85% (95%CI, 74-91%) ≥7 days following a second dose and estimates were similar over time. VE against symptomatic Omicron infection was 62% (95%CI, 49-72%) ≥7 days following a third dose.DiscussionTwo-dose VE against symptomatic Omicron infection wanes over time in adolescents. While lower than observed against Delta, protection against severe outcomes appears to be maintained over time. A third dose substantially improves protection against Omicron infection, but 3-dose VE is only moderate at approximately 60% in the early period following vaccination and the duration of this protection is unknown.
Understanding women’s help-seeking for problematic and unhealthy alcohol use through the lens of complexity theory
Authors: Cane Tam Chipawe , Newton Paul , Foster John 
Published: April 2022

Purpose
It is well established that women face multiple barriers accessing treatment for problematic and unhealthy alcohol use, but less is known about how their interconnected problems affect how they seek help from, and access, alcohol-treatment services. This study aims to explore the dynamic nature of women’s help-seeking for problematic and unhealthy alcohol use and how this can be compounded by unsuitable treatment services, especially when women present with complex needs.

Design/methodology/approach
Thirteen semi-structured interviews with women who had accessed alcohol-support services were conducted, audio-recorded, transcribed and analysed thematically using the complexity theory.

Findings
For women with complex needs, the process of seeking help may trigger unpredictable behaviours, health or social problems and intermittent serial access to treatment. Current services do not always address women’s holistic needs. Unless services focus on addressing interconnected problems – including historic trauma – they may compound the complexity of women’s problems. Complexity theory offers novel insights into this process, a concept not applied to problematic and unhealthy alcohol use treatment previously.

Research limitations/implications
Services should adopt the complexity-focused perspective featured in this study. While the authors acknowledge the increase in gender-responsive provision, the limitations of this study include a small sample size, the self-selecting nature of the sample and retrospective reporting. Participants were recruited and selected by service staff resulting in gatekeeping and possible sampling bias.

Practical implications
Services should adopt non-linear approaches to treatment. Implementing complexity approaches to treating women’s problematic and unhealthy alcohol use should capture the dynamics, complexity and non-linear nature of women’s help-seeking journeys as well as their internal and external responses that may result in relapse. The authors recommend complexity-focused, multiple-component and integrated collaborative strategies to address not only addiction but also all components of women’s needs, including past trauma.

Originality/value
Applying complexity-thinking to help-seeking experiences for alcohol treatment and recovery services is novel and proved useful in understanding the variety of women’s experiences and how these interact with their help-seeking behaviours, including treatment environments.
Effect of social media addiction on eating behavior, body weight and life satisfaction during pandemic period
Authors: Ayyıldız Feride , Şahin Gülşah 
Published: April 2022

PurposeThe aim of this study was to evaluate the relationship between social media addiction and eating behavior, eating disorder risk, body weight and life satisfaction in university students during pandemic period.Design/methodology/approachThe sample consists of 1,411 university students. Data were collected using online questionnaire and Scale of Social Media Usage Motives, Social Media Addiction Scale-Student Form, Dutch Eating Behavior Questionnaire (DEBQ), SCOFF Eating Disorders Scale and Life Assessment Scale were used in the study.FindingsOf the participants, 79.7% had different levels of social media addiction. Body weight and body mass index (BMI) values of those with high social media addiction were significantly higher than those in the non- and low-addicted group (p < 0.05). There was a positive relationship between social media addiction and duration of social media use, social media addiction and emotional and external eating behaviors and a negative relationship between social media addiction and life satisfaction (p < 0.01). There was no significant difference in eating disorder risk according to social media addiction groups (p = 0.823). Individuals in the nonaddicted social media group had the highest Life Assessment Scale score (p < 0.01).Originality/valueSocial media addiction was prevalent among university students, and it was related to BMI, eating behavior and life satisfaction. It is necessary to be more careful in the use of social media, which has increased in the pandemic period. Trainings to reduce the use of social media can positively affect eating behavior and contribute to the prevention of obesity and increasing life satisfaction.
Young adults’ default intention: influence of behavioral factors in determining housing and real estate loan repayment in India
Authors: Thomas Sherin Susan , George Jossy P. , Godwin Benny J. , Siby Amala 
Published: April 2022

Purpose
The primary purpose of this paper is to determine the role of behavioral characteristics of young adults on housing and real estate loan default intentions. The behavioral factors considered in this study are financial literacy, materialism, emotions, indebtedness and risk perception.

Design/methodology/approach
The sample frame comprises of young clients who have taken house loans and work in India’s metropolitan cities. These cities provide a higher quality of life, more employment possibilities and cheaper living costs. A systematic questionnaire was used, which was divided into six components. A total of 352 valid responses were collected and analyzed through a structural equation model.

Findings
The findings suggest that financial literacy, materialism and risk perception have a considerable impact on loan default intention among young adults. The results also ascertained that emotion and indebtedness do not have a considerable impact on loan default intention among young adults.

Research limitations/implications
The scope of this study is limited to India’s metropolitan cities. Future studies can examine comparative examinations of young adults working in the public and private sectors and those working in different cities across India.

Practical implications
This paper contributes to a better understanding of behavioral variables which may lead to the creation of preventive measures for young defaulters. The findings of this study will help financial institutions to improve their credit-offering models.

Originality/value
To the best of the authors’ knowledge, this study is the first to determine the role of behavioral attributes of young adults on housing and real estate loan default intentions in India. This work will be executable to all the stakeholders of the housing and real estate industry altogether.
Technology-based business incubators: the impacts on resources of startups in Brazil
Authors: Dourado Freire Clarissa , Sacomano Neto Mário , Moralles Herick Fernando , Rodrigues Antunes Luiz Guilherme 
Published: April 2022

PurposeThis paper aims to analyze the influence of technology-based business incubators (TBIs) on the resources of technology startups in Brazil. The authors identify which resources are offered and explore the importance of resources for TBIs and startups. The theoretical background is based on the resource-based view, the resource dependency theory and total factor productivity.Design/methodology/approachThe study is characterized by a descriptive approach. The method includes a multiple case study and a survey. For data collection, we conducted interviews with three managers from TBIs and distributed questionnaires to 30 startup founders. The content analysis supports the identification of the resources, while the quantitative approach explores the relationship between total factor productivity and resources.FindingsResources are the linkage between startups and TBIs, promoting the development and continuity of these organizations. Among the resources offered by TBIs, the most representative is physical resources, due to the early stage of startups. TBIs do not offer financial resources directly but facilitate access through networks with other actors.Research limitations/implicationsThe research implications depict the importance of resources as a link between TBIs and startups. The results highlight how TBIs play an important role in promoting entrepreneurship and innovation in the context of emerging economies such as Brazil.Originality/valueThis article performs a multi-theoretical analysis, addressing the perspectives concerning resources. No previous study has used this combination of perspectives to analyze the relationship between TBIs and startups in Brazil, filling the gap about this subject in emerging economies.
Quality, resilience, sustainability and excellence: understanding LEGO’s journey towards organisational excellence
Authors: Dahlgaard Jens Jörn , Anninos Loukas N. 
Published: April 2022

Purpose
This study aims to reflect on quality, sustainability and resilience as emerging organisational priorities within total quality management (TQM) and organisational excellence.

Design/methodology/approach
The paper uses a conceptual approach based on reflection and theoretical studies on the philosophical foundations of quality, excellence, resilience and sustainability as cornerstones for organisational excellence. Bearing in mind that sustainable excellence rests upon a combination of systemic and soft issues that define organisational ability for resilience and sustainability, there is a need to analyse and reflect on short business cases from world-leading companies and further reflect on the fundamental principles, which have helped such companies to survive, grow and sustain. This study includes such a business case – the LEGO case. In addition, a Japanese case has been included. Japanese training material on human motivation developed in the 1980s exemplifies how company managers were trained, at that time, to understand and practice human motivation, excellence principles and tools.

Findings
Organisational excellence constitutes an evolving concept as the world becomes more chaotic and interconnected with multiple disruptive shocks. Organisational excellence challenges the inflexibilities of Newtonian mindsets, recognising the paramount importance of interactions and further underlining the significance of invisible elements such as human potentiality, motivation and values that formulate the principles of organisational excellence.

Originality/value
The paper investigates the notions of quality, resilience and sustainability and their relation to motivation and organisational excellence within the framework of business management and TQM. A world-leading company – LEGO – will be used to exemplify the theoretical findings together with the Japanese Motivation Training Programme case.
Role of social sustainability for financial inclusion and stability among Asian countries
Authors: Malik Arsalan Haneef , Jais Mohamad Bin , Md Isa Abu Hassan , Rehman Awais Ur 
Published: April 2022

PurposeAsia is the largest and most densely inhabited region in the world. Despite exhibiting an extremely expeditious economic growth, the majority of the world population categorized as poor resides in Asia, with more than a billion people financially excluded. This study aims to assess how social sustainability (SS) may increase financial inclusion (FI) and maintain financial stability (FS) in Asia.Design/methodology/approachEstablished on the stakeholder theory, the study analyzed the association among SS, FI and FS in Asia, employing a generalized method of moment’s estimation. The mediation of FI was also investigated in the relationship between SS and FS. Moreover, this study has analyzed the alternative proxies for the variables of interest to ensure dynamic results.FindingsThe findings point toward a positive association among SS, FI and FS. Furthermore, FI is observed to be undertaking a partial mediating role between SS and FS.Practical implicationsThis study emphasizes that both SS and FI have individual parts in the amelioration of FS in Asia, whereas previous studies implied that FI is a mere tool for stimulating SS. Hence, Asian policymakers must keep these outcomes in mind due to their simultaneous contribution to FS.Originality/valueThe relationship between SS, FI and FS has received little attention in the literature. No previous study has deduced that increasing SS may instigate an increase in FI and FS. Additionally, quite contrary to previous studies that relied on narrow indicators, this study develops a broad measurement of SS by considering a wide range of crucial indicators for a sustainable society.
Redefining the role of young farmers: participatory action youth-led urban agriculture
Authors: DeMarsh Nicholas 
Published: April 2022

PurposeThe research illustrates the impact of young people shaping a community-based program.Design/methodology/approachFrom the perspective of a youth educator, this research uses participatory action research (PAR) in youth urban agriculture education.FindingsFindings illustrate how youth-led programming creates new processes, revealing new educational opportunities. Outcomes of education programs are strengthened by engaging with students in ways that interest them.Practical implicationsFindings illustrate opportunities for social network bonding through community-based farm stands and challenges in social network bridging through Community Supported Agriculture (CSAs).Originality/valuePrevious articles have noted the need for practitioner perspective in youth education. Scholars have also noted the lack of research that assesses the role of youth urban agriculture programming to advance community engagement. This article contributes to both.