bluuebunny/crossref_metadata_2025_split huggingface dataset:
MEMBANGUN KAREKTER GENERASI MUDA MELALUI OLAHRAGA KARATE DI DOJO BUANA IMPIAN II KELURAHAN TEMBESI- KECAMATAN SAGULUNG – KOTA BATAM
Authors: Wage Sunarto , Johan Mhd , Efendi Syahril 
Published: February 2022

Latihan olahraga karate di laksanakan setiap hari Sabtu dan hari Minggu setiap minggunya yang berlokasi di Fasum RT 002 RW 028 Perumahan Buana Impian 2 mulai jam 16.00 – 18.00 Wib. Peserta latihaj olahraga karate saat ini berjumlah 46 siswa yang berasal dari sekitar perumahan Buana 2 seperti; Perumahan Buana Impian 1, Perubahan Bumi Sakinah, Perumahan Citra Laguna, dan Perumahan Bukit Pertama. Peserta Latihan olahraga karate sangat antusias mengikuti latihan setiap minggunya dan orang tuanya juga sangat mendukung kegiatan olahraga karate yang diikuti oleh putra dan putrinysa. Latihan olahraga karate di Perumahan Buana Impian 2 sudah berjalan 2 tahun yang di mulai pada tanggal 13 November 2019 dalam kelompok kegiatan olahraga ‘DOJO BUANA IMPIAN 2 – ASKI – KEPRI’. Pengabdian kepada masyarakat kepada siswa-siswa karate di Perumahan Buana Imian 2 ini bertujuan untuk memberi bekal kepada siswa tentang pentingnya olahraga karate untuk membentuk karakter yang baik di samping untuk melatih olahraga karate itu. Teknik pengabdian ini dilaksanakan setiap hari Sabtu dan hari Minggu kepada siswa-siswa karate di Perumahan Buana Impian 2. Setelah mengikuti kegiatan olahraga karate diharapkan siswa-siswa memperoleh prestasi dibidang olahraga karate dan memiliki karakter yang baik.
Clinical Significance and Immune Landscape of a Pyroptosis-Derived LncRNA Signature for Glioblastoma
Authors: Xing Zhe , Liu Zaoqu , Fu Xudong , Zhou Shaolong , Liu Long , Dang Qin , Guo Chunguang , Ge Xiaoyong , Lu Taoyuan , Zheng Youyang , Dai Lirui , Han Xinwei , Wang Xinjun 
Published: February 2022

Introduction: Pyroptosis was recently implicated in the initiation and progression of tumors, including glioblastoma (GBM). This study aimed to explore the clinical significance of pyroptosis-related lncRNAs (PRLs) in GBM.Methods: Three independent cohorts were retrieved from the TCGA and CGGA databases. The consensus clustering and weighted gene coexpression network analysis (WGCNA) were applied to identify PRLs. The LASSO algorithm was employed to develop and validate a pyroptosis-related lncRNA signature (PRLS) in three independent cohorts. The molecular characteristics, clinical significances, tumor microenvironment, immune checkpoints profiles, and benefits of chemotherapy and immunotherapy regarding to PRLS were also explored.Results: In the WGCNA framework, a key module that highly correlated with pyroptosis was extracted for identifying PRLs. Univariate Cox analysis further revealed the associations between PRLs and overall survival. Based on the expression profiles of PRLs, the PRLS was initially developed in TCGA cohort (n = 143) and then validated in two CGGA cohorts (n = 374). Multivariate Cox analysis demonstrated that our PRLS model was an independent risk factor. More importantly, this signature displayed a stable and accurate performance in predicting prognosis at 1, 3, and 5 years, with all AUCs above 0.7. The decision curve analysis also indicated that our signature had promising clinical application. In addition, patients with high PRLS score suggested a more abundant immune infiltration, higher expression of immune checkpoint genes, and better response to immunotherapy but worse to chemotherapy.Conclusion: A novel pyroptosis-related lncRNA signature with a robust performance was constructed and validated in multiple cohorts. This signature provided new perspectives for clinical management and precise treatments of GBM.
A Characteristic Interval Modeling Method for Simultaneous Detection of Multiple Metal Ions
Authors: Zhou Feng-Bo , Li Chang-Geng , Zhu Hong-Qiu 
Published: February 2022

Abstract Aiming at the problems of low accuracy and large prediction errors caused by the serious overlap of multi-metal spectral signals in zinc smelting industrial wastewater, a characteristic interval modeling method is proposed. First, according to the absorption spectra of mixed solution, the characteristic intervals of copper and nickel are preliminarily screened by using different partition lengths. Second, take the smallest root mean squares error of cross validation and the largest correlation coefficient as the evaluation indicators, compare the full-spectral model and each local model, and select the optimal feature sub-intervals of copper and nickel. Last, the partial least squares method is used to model the combined wavelengths of the optimal sub-intervals to realize the simultaneous detection of copper and nickel. The linear determination ranges are 0.3–3.0 mg/L for copper and nickel. the correlation coefficients of copper and nickel are 0.9974 and 0.9966, respectively. The results show that the method reduces the complexity of the wavelength variable screening process, improves the accuracy of the model, and lays the foundation for the accurate analysis of polymetallic ions in zinc smelting industrial wastewater.
Hyperhomocysteinemia Increases Risk of Metabolic Syndrome and Cardiovascular Death in an Elderly Chinese Community Population of a 7-Year Follow-Up Study
Authors: Liu Chang , Liu Liping , Wang Yinglu , Chen Xiaoli , Liu Jie , Peng Sheng , Pi Jingjiang , Zhang Qi , Tomlinson Brain , Chan Paul , Zhang Lin , Fan Huimin , Zheng Liang , Liu Zhongmin , Zhang Yuzhen 
Published: February 2022

BackgroundHyperhomocysteinemia (HHcy) and abdominal obesity are risk factors for metabolic syndrome (MetS) and death from cardiovascular disease (CVD). Recent studies have shown a correlation between HHcy and abdominal obesity, suggesting that they may have a combined effect on the risk of MetS and CVD mortality. However, this suspicion remains to be confirmed, particularly in the elderly population. We explored their combined effects on the risk of MetS and CVD mortality among the community population aged 65 and above in China.Methods and ResultsThis prospective study enrolled 3,675 Chinese community residents aged 65 and above in May 2013 with 7-year follow-up of all-cause and CVD mortality. HHcy was defined as the blood homocysteine (Hcy) level &gt;15 μmol/L and abdominal obesity as waist circumference (WC) ≥90 cm for men and ≥80 cm for women (HWC). All participants were grouped into four categories by WC and the blood level of Hcy: NWC (normal WC) /HHcy(–), NWC/HHcy(+), HWC/HHcy(–), and HWC/HHcy(+). The relationship of combined HHcy and abdominal obesity with MetS and metabolic profile was evaluated by logistic regression analysis and the association of combined HHcy and abdominal obesity with CVD and all-cause mortality evaluated by Cox regression analysis. The prevalence of HHcy, abdominal obesity and MetS in elderly Chinese community residents was 40.1, 59.3, and 41.4%, respectively. Using group without HHcy and abdominal obesity [NWC/HHcy(–)] as reference, the participants of other three groups had significantly higher risk of MetS and its component abnormalities, with HWC/HHcy(+) group having the highest risk (OR = 13.52; 95% CI = 8.61–14.55). After a median of 6.94 (±1.48) years follow-up, 454 deaths occurred with 135 CVD deaths. Compared with NWC/HHcy(–) group, the risk of 7-year follow-up CVD mortality (HR = 1.75; 95% CI = 1.02–3.03) and all-cause mortality (HR = 1.23; 95% CI = 1.04–2.18) of HWC/HHcy(+) group increased considerably after adjustment for major MetS and CVD risk factors.ConclusionsThere is high prevalence of HHcy, abdominal obesity, and MetS in the elderly Chinese community population. HHcy increases risk of MetS, CVD, and all-cause mortality, especially in the populations with abdominal obesity.
Structural Properties of Syngenetic Ice-Rich Permafrost, as Revealed by Archaeological Investigation of the Yana Site Complex (Arctic East Siberia, Russia): Implications for Quaternary Science
Authors: Pitulko Vladimir V. , Pavlova Elena Y. 
Published: February 2022

Ice-rich syncryogenic (termed “Ice Complex”) deposits are common in northern East Siberia and constitute the most important feature of the Quaternary geology of the region. The Ice Complex formed throughout the Late Pleistocene and not only contains an archive of paleoenvironmental proxies such as Pleistocene faunal remains, but also comprises a record of human habitation spanning ∼50,000 years, beginning with early MIS3. The development of syngenetic permafrost is an important variable in the formation of archaeological contexts in this depositional setting. Excavations of the Yana site complex in the lower Yana River area provide a unique opportunity to study archaeological finds preserved in Ice Complex deposits. Based on long-term field observations and dating results, we present important conclusions concerning the geology of the Yana sites. Taphonomic biases with potential to obscure the archaeological record are discussed. The thawing of frozen primary deposits has distorted depositional sequences, leading to the formation of secondary features and contexts, e.g., ice-wedge casts. Collapsed blocks of frozen sediment with undisturbed fragments of frozen layers containing artifacts and/or paleobiotic remains may become incorporated and refrozen into another depositional sequence and a source of misinterpretation and chronometric error. Furthermore, severe cryoturbation within the polygonal mounds warps the sediment in contact with the ice wedges; as a result, the contents of the sediment is uplifted with important consequences: 1) the hypsometric provenience of datable material is altered, creating chronometry problems; 2) in archaeology, there is an increased potential for misinterpretations with respect to dating, cultural classification, and human behavior; 3) transported material may form secondary concentrations at different hypsometric levels and thus bring further complications for its understanding; 4) in geology, the transportation of geochemical signatures may lead to erroneous interpretation of the geological potential of the area; 5) uplifted deposits contribute to increased Ice Complex thickness, which is thus not a direct function of sedimentation, but a combined result of sedimentation and redistribution of the deposits within an existing polygon deposit. Thus, the analysis of Ice Complex deposits during archaeological excavations at the Yana site complex has wider implications for Quaternary science.
Long-term Performance Evaluation and Economic Analysis for Deep Borehole Heat Exchanger Heating System in Weihe Basin
Authors: Cai Wanlong , Wang Fenghao , Jiang Jinghua , Wang Zeyuan , Liu Jun , Chen Chaofan 
Published: February 2022

To reduce carbon emission and achieve carbon neutrality, deep geothermal energy has been widely extracted for building heating purpose. In recent years, deep borehole heat exchanger (DBHE) heating system has gained more attention, especially in densely populated urban areas in Weihe Basin, northern China. The long-term performance and the economic feasibility are essential for the system application. In this work, the DBHE model implemented in OpenGeoSys software is verified against an analytical solution and a comprehensive economic analysis approach is further proposed. Then the short-term thermal performance tests are conducted to obtain the tentative heat extraction capacity for long-term simulation. The long-term simulations are further performed with the heat pump unit under the adjusted tentative heat extraction rate imposed on the DBHE. Finally, a comprehensive economic analysis is applied to the DBHE heating system over 15 heating seasons. Results show that the minimum coefficient of performance value of the heat pump is 4.74 over the operation of 15 heating seasons. With the increase of depth for the DBHE, the total electricity consumption of heat pumps and circulation pumps has a prominent promotion. With the comprehensive approach of economic analysis, the depth of 2,600 m has the lowest levelized cost of total heating amount, which is the best system design for the application in Weihe Basin. The present results are specific to the conditions in Weihe Basin, but the proposed economic analysis approach is generic.
Tectonic Deformation of the Western Qilian Shan in Response to the North–South Crustal Shortening and Sinistral Strike-Slip of the Altyn Tagh Fault Inferred From Geomorphologic Data
Authors: Chen Zhidan , Xu Wenbin , Liu Rui , Li An , Koronovsky N. V. 
Published: February 2022

The tectonic deformation of a series of NWW-trending compressional band-shaped mountains and fault zones in the Qilian Shan, northeastern Tibet, plays an important role in absorbing the north–south crustal shortening of the Tibetan Plateau and accommodating the sinistral strike-slip of the Altyn Tagh fault. However, the deformation pattern of these mountains and fault zones in response to crustal shortening and sinistral strike-slip remains to be investigated. In this study, we present the slope map and swath profiles of the western Qilian Shan extracted from high-resolution digital elevation model (DEM) data and the fluvial geomorphologic characteristics of the Baiyang river in the northwestern Qilian Shan. Our data indicate that the crustal uplift of the northern Qilian Shan is stronger than that of the central and southern ranges of the Qilian Shan because of the high-terrain relief and stronger erosion. In addition, the deformed terraces of the Baiyang river documented the activity of NWW-trending faults in the western Qilian Shan. Based on the longitudinal profiles and ages of the deformed river terraces, the vertical slip rates of the Changma, Yumen, and Bainan faults in the western Qilian Shan since ∼60 ka were constrained to be 0.31 ± 0.06, 0.33 ± 0.02, and 0.24 ± 0.02 mm/a, respectively. Based on the comparison with previous studies, we noticed that the rate of the vertical slip since the Late Quaternary of the northern Qilian fault of 1.5–2 mm/a is significantly higher than that of the Changma fault of 0.3–0.6 mm/a, which matches the terrain relief in the Qilian Shan and demonstrates that the northern Qilian Shan has been rising faster than its southern ranges. From the slip rates of the NWW-trending faults in the western Qilian Shan, we suggest that the crustal shortening is widely distributed in the NWW-trending compressional orogenic belts and fault zones across the Qilian Shan, among which the northern Qilian Shan and its frontal thrust system absorb the greatest shortening amount, whereas strike-slip faults within the Qilian Shan accommodate most of the sinistral strike-slip of the Altyn Tagh fault.
Cox-LASSO Analysis for Hospital Mortality in Patients With Sepsis Received Continuous Renal Replacement Therapy: A MIMIC-III Database Study
Authors: Wang Chunxia , Zheng Jianli , Wang Jinxia , Zou Lin , Zhang Yucai 
Published: February 2022

BackgroundSepsis remains the leading cause of mortality in-hospital in the intensive care unit (ICU). Continuous renal replacement therapy (CRRT) is recommended as an adjuvant therapy for hemodynamics management in patients with sepsis. The aim of this study was to develop an adaptive least absolute shrinkage and selection operator (LASSO) for the Cox regression model to predict the hospital mortality in patients with Sepsis-3.0 undergoing CRRT using Medical Information Martin Intensive Care (MIMIC)-III v1.4.MethodsPatients who met the Sepsis-3.0 definition were identified using the MIMIC-III v1.4. Among them, patients who received CRRT during ICU hospitalization were included in this study. According to the survival status, patients were split into death or survival group. Adaptive LASSO for the Cox regression model was constructed by STATA software. At last, nomogram and Kaplan-Meier curves were drawn to validate the model.ResultsA total of 181 patients who met Sepsis 3.0 criteria received CRRT were included in the study, in which, there were 31 deaths and 150 survivals during hospitalization, respectively. The overall in-hospital mortality was 17.1%. According to the results of multivariate Cox-LASSO regression analysis, use of vasopressor, international normalized ratio (INR) ≥1.5, and quick sequential organ failure assessment (qSOFA) score were associated with hospital mortality in patients with sepsis who underwent CRRT, but lactate level, mechanical ventilation (MV) support, PaO2/FiO2, platelet count, and indicators of acute kidney injury (AKI), such as blood urea nitrogen (BUN) and creatinine, were not independently associated with hospital mortality after adjusted by qSOFA. The risk nomogram and Kaplan-Meier curves verified that the use of vasopressor and INR ≥1.5 possess significant predictive value.ConclusionsUsing the Cox-LASSO regression model, use of vasopressor, INR ≥1.5, and qSOFA score are found to be associated with hospital mortality in patients with Sepsis-3.0 who received CRRT. This finding may assist clinicians in tailoring precise management and therapy for these patients who underwent CRRT.
Feasibility of Dialysate Bolus-Based Absolute Blood Volume Estimation in Maintenance Hemodialysis Patients
Authors: Krenn Simon , Schmiedecker Michael , Schneditz Daniel , Hödlmoser Sebastian , Mayer Christopher C. , Wassertheurer Siegfried , Omic Haris , Schernhammer Eva , Wabel Peter , Hecking Manfred 
Published: February 2022

BackgroundAbsolute blood volume (ABV) is a critical component of fluid status, which may inform target weight prescriptions and hemodynamic vulnerability of dialysis patients. Here, we utilized the changes in relative blood volume (RBV), monitored by ultrasound (BVM) upon intradialytic 240 mL dialysate fluid bolus-infusion 1 h after hemodialysis start, to calculate the session-specific ABV. With the main goal of assessing clinical feasibility, our sub-aims were to (i) standardize the BVM-data read-out; (ii) determine optimal time-points for ABV-calculation, “before-” and “after-bolus”; (iii) assess ABV-variation.MethodsWe used high-level programming language and basic descriptive statistics in a retrospective study of routinely measured BVM-data from 274 hemodialysis sessions in 98 patients.ResultsRegarding (i) and (ii), we automatized the processing of RBV-data, and determined an algorithm to select the adequate RBV-data points for ABV-calculations. Regarding (iii), we found in 144 BVM-curves from 75 patients, that the average ABV ± standard deviation was 5.2 ± 1.5 L and that among those 51 patients who still had ≥2 valid estimates, the average intra-patient standard deviation in ABV was 0.8 L. Twenty-seven of these patients had an average intra-patient standard deviation in ABV &lt;0.5 L.ConclusionsWe demonstrate feasibility of ABV-calculation by an automated algorithm after dialysate bolus-administration, based on the BVM-curve. Based on our results from this simple “abridged” calculation approach with routine clinical measurements, we encourage the use of multi-compartment modeling and comparison with reference methods of ABV-determination. Hopes are high that clinicians will be able to use ABV to inform target weight prescription, improving hemodynamic stability.
Orthokeratology Lens Wear for 2 Years in Children Did Not Alter Tear Film Lipid Thickness by Non-Invasive Interferometry
Authors: Yu Haozhe , Yuan Yifei , Wu Wenyu , Zeng Weizhen , Tong Louis , Zhang Yu , Feng Yun 
Published: February 2022

PurposePrevious studies suggest that overnight orthokeratology (OOK) may be detrimental to tear function. We aimed to investigate the effect of OOK on lipid layer thickness (LLT), blink pattern, and meibomian gland and elucidate the relationship of these variables.MethodsThirty-seven participants who wore OOK lenses every night for at least 2 years and twenty-four healthy non-contact lens wearers (controls) were enrolled in this retrospective study. LipiView interferometry, blink pattern analysis, the ocular surface status, and morphology and function of the meibomian gland were determined.ResultsThe OOK group and healthy controls had similar LLT, blink patterns, ocular surface status, and the function of the meibomian gland. OOK participants demonstrated higher meiboscore in the lower eyelids (p &lt; 0.05) but not in the upper eyelids. Within the OOK group, LLT was significantly impacted by the partial blink rate (p &lt; 0.05) and the total score of the upper meibomian gland (p = 0.10).ConclusionsWearing OOK for 2 or more years increased lower eyelid meibomian gland dropout but did not have a reduction of LLT.
Structural and Functional Analysis of Nonheme Iron Enzymes BCMO-1 and BCMO-2 from Caenorhabditis elegans
Authors: Pan Weimin , Zhou Yong-Ling , Wang Jian , Dai Huai-En , Wang Xiao , Liu Lin 
Published: February 2022

Carotenoid metabolism is critical for diverse physiological processes. The nematode Caenorhabditis elegans has two genes that are annotated as β-carotene 15,15′-monooxygenase (BCMO) and are 17 centimorgan apart on chromosome II, but the function of BCMO-1 and BCMO-2 remains uncharacterized. Sequence homology indicates that the two enzymes belong to the carotenoid cleavage dioxygenase family that share a seven-bladed β-propeller fold with a nonheme iron center. Here we determined crystal structures of BCMO-1 and BCMO-2 at resolutions of 1.8 and 1.9 Å, respectively. Structural analysis reveals that BCMO-1 and BCMO-2 are strikingly similar to each other. We also characterized their β-carotene cleavage activity, but the results suggest that they may not act as β-carotene 15,15′-oxygenases.
The Frontal and Cerebellar Metabolism Related to Cognitive Dysfunction in Multiple System Atrophy
Authors: Shen Cong , Chen Qi-Si , Zuo Chuan-Tao , Liu Feng-Tao , Wang Jian 
Published: February 2022

BackgroundCognitive dysfunctions have been reported in multiple system atrophy (MSA). However the underlying mechanisms remain to be elucidated. This study aimed to explore the possible cerebral metabolism associated with domain-specific cognitive performances in MSA.MethodsA total of 84 patients were diagnosed as probable or possible MSA, comprised of 27 patients as MSA with predominant parkinsonism (MSA-P) and 57 patients as MSA with predominant cerebellar ataxia (MSA-C). The comprehensive neuropsychological tests and 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography (PET) imaging were performed. Z-score was calculated to non-dimensionalize and unify indicators of different tests in the domains of executive function, attention, language, memory, and visuospatial function. Correlations between specific Z-score and cerebral 18F-FDG uptake were analyzed using statistical parametric mapping. The cognition-related metabolic differences between patients with MSA-P and MSA-C were analyzed using the post-hoc test.ResultsZ-scores of the domains including attention, executive function, and language correlated positively with the metabolism in the superior/inferior frontal gyrus and cerebellum, but negatively with that in the insula and fusiform gyrus (p &lt; 0.001). No significant differences in neuropsychological performances and frontal metabolism were found between patients with MSA-P and MSA-C. Only lower metabolism in the cerebellum was observed in MSA-C.ConclusionMetabolic changes in the frontal lobe and cerebellum may participate in the cognitive impairments of patients with MSA. Nevertheless, cognitive and corresponding metabolic differences between the two subtypes of MSA still need more exploration.