bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficacy and safety of ultra-low dose inhaled melphalan in the treatment of hospitalized patients with COVID-19
Authors: Sinitsyn E. A. , Zykova A. A. , Shamin R. V. , Rvacheva A. V. , Bogatyreva A. O. , Shapovalenko T. V. , Maryin G. G. , Zykov K. A. 
Published: May 2022

Background. One of the most important components of COVID-19 therapy is the suppression of the hyperergic immune response. There is an urgent need of creating the optimal tactics of efficient and safe anti-inflammatory therapy. A new method of treatment of COVID-19 with inhalation of ultra-low (non-cytotoxic) doses of the alkylating drug melphalan is proposed, based on previous experimental, preclinical, and clinical data on its use in severe bronchial asthma.The aim. To evaluate the efficacy and safety of inhalation of ultra-low doses of melphalan in hospitalized patients with COVID-19-associated lung damage.Materials and methods. A prospective, open, controlled, blind for the central expert study was conducted. Sixty adult patients were included, 30 patients were consecutively admitted to the hospital and received nebulized inhalations of 0.1 mg of melphalan for 7 days. Thirty patients of the control group were selected by an independent expert retrospectively using the computer algorithm for selecting «close» patients based on the «case-control» principle. The primary endpoints were the dynamics on the WHO Clinical Improvement Scale and the dynamics of dyspnea according to the modified Borg scale, secondary – assessment of adverse events, dynamics of indicators of clinical, biochemical blood tests, lungs computed tomography data from the beginning of inhalations in the melphalan group and from the corresponding day in the control group.Results. Inhalations of melphalan led to a significant improvement in the clinical condition of patients according to the WHO scale, decrease in the intensity of dyspnea on day 7 of treatment and by the time of discharge, a significant anti-inflammatory effect. Adverse events and dynamics of laboratory parameters did not differ from the control group.Conclusion. The method of treatment of COVID-19 by inhalation of ultra-low doses of the alkylating drug melphalan is safe and leads to a significant clinical improvement of hospitalized patients with COVID-19-associated lung damage.
Individualization and digitalization of creative development of students in chemistry lessons
Authors: Stepanov S. Yu. , Orzhekovskiy P. A. 
Published: May 2022

Background. In the context of increasing robotization and digitalization of most of the routine and algorithmic types of human activity, the problem of the creative development of each child and the individualization of education in a public school, especially in the field of natural science education, arises.The aim. To study the prerequisites and opportunities for digitalization of the creative development of students as a means of increasing the reflexivity of their mental activity in solving creative problems and individualizing the educational process in a public school based on the subject of chemistry.Methods. At the first stage of the study, a survey of chemistry teachers was used. At the second stage, diagnostic tasks in chemistry were developed to verify the identified stereotypes; at the third stage, ways were studied to overcome stereotyped ideas in chemistry by schoolchildren; and at the fifth stage, the possibility of digitizing mental actions using the CREO_DATUM computer program was studied.Results. Of the 70 different variants of erroneous ideas in the school chemistry course, 18 thinking stereotypes turned out to be the most common. The possibility of overcoming stereotypes is not associated with additional classes and explanations of teachers, but with the independent solution of creative tasks by students, since in this process the reflection of schoolchildren develops, which is a condition for overcoming stereotypes. The optimal time in the classroom for students to complete short creative tasks is 10–12 minutes. It is sufficient to measure such creative actions of students as divergence, criticality, uniqueness. To digitize the mental activity of students when solving creative problems in chemistry and to automate the construction of graphs for the creative development of each student, the CREO_DATUM program was developed and tested.Conclusion. Long-term studies of the possibility of using subject-creative tasks based on the material of a school chemistry course for the development of creativity and reflexivity of students serve as a rationale for designing digital means for individualizing the creative development of students.
Screening for tuberculosis of patients with HIV-infection. New possibilities
Authors: Borodulina E. A. , Kudlay D. A. , Kuznetsova A. N. 
Published: May 2022

Background. Tuberculosis associated with HIV infection is becoming almost a new disease, where not only new approaches to treatment are being formed, but there is also a need to improve the quality and search for new means of early diagnosis of tuberculosis infection.The aim. To evaluate the diagnostic performance of the T-SPOT.TB test for the detection of latent tuberculosis infection and clinical forms of tuberculosis in patients with HIV infection.Materials and methods. 396 patients registered at the AIDS Center for more than a year were examined. Everyone underwent standard examinations for pulmonary tuberculosis using sputum bacterioscopy techniques with Ziehl – Neelsen staining; a molecular genetic method based on hybridization technology – HAIN-GenoType MTBDRplus; crops on liquid media in the automated BACTEC MGIT 960 system and on Löwenstein–Jensen dense medium. T-SPOT.TB was conducted as a screening for everyone. With positive T-SPOT.TB results, negative results of the MBT search, absence of specific changes on the X-ray a conclusion was made about latent tuberculosis infection. Statistical data processing was carried out using the software package Statistica 10 (StatSoft Inc., USA).Results. According to the results of a comprehensive examination, tuberculosis was diagnosed in 174 patients, verified using various methods of searching for Mycobacterium tuberculosis in 116 patients (66.6 %). Infiltrative (63.8 %) and disseminated (24.7 %) tuberculosis were more often diagnosed. Latent tuberculosis infection was diagnosed in 52 patients, 170 HIV-infected patients have no data for tuberculosis at this stage.Conclusions. T-SPOT.TB can be used in the diagnostic complex of monitoring patients with HIV infections – as a screening method to detect latent tuberculosis, for preventive chemotherapy.
PENERAPAN METODE ARIMAX PADA PERAMALAN PRODUKSI DAGING SAPI DI SUKOHARJO
Authors: Ardyansyah Fitrian Nur , Sulandari Winita , Sugiyanto Sugiyanto 
Published: May 2022

Daging sapi merupakan salah satu sumber protein kaya akan zat gizi yang diperlukan oleh tubuh. Kebutuhan gizi dapat mempengaruhi jumlah permintaan daging sapidi masyarakat. Produksi daging sapi umumnya dipengaruhi momen atau peristiwa tertentu seperti Hari Raya Idul Adha yang erat kaitannya dengan pelaksanaan ibadah kurban.Penentuan Hari Raya Idul Adha tidak mengikuti kalender Masehi, tetapi berdasarkan kalender Hijriyah. Perbedaan penggunaan kalender Masehi dan Hijriyah pada suatu dataruntun waktu menyebabkan adanya efek variasi kalender. Pemodelan untuk data runtunwaktu yang mengandung variasi kalender dapat dilakukan dengan menggunakan metodeAutoregressive Integrated Moving Average Exogenous (ARIMAX). Data yang digunakan,dalam penelitian ini adalah data jumlah produksi daging sapi di Sukoharjo bulan Januari2007 sampai bulan Desember 2020. Data dibagi menjadi dua, yaitu data training sejumlah157 observasi dan data testing sejumlah 12 observasi. Variabel eksogen menggunakanvariabel dummy dua belas bulan, dummy bulan saat Hari Raya Idul Adha, dan dummy bulansetelah Hari Raya Idul Adha. Hasil analisis menunjukan model ARIMAX(1,0,1) merupakan model terbaik dengan nilai RMSE sebesar22053,11. Model ini dapat digunakan untuk memproyeksikan pola data produksi daging sapidi Sukoharjo.
Uma “caça às bruxas” centro-africana: os juramentos do bulungo em Massangano (Angola) em 1717
Authors: Marcussi Alexandre Almeida 
Published: May 2022

Este artigo analisa uma denúncia enviada no ano de 1717 da vila de Massangano, em Angola, ao tribunal da Inquisição de Lisboa, na qual numerosos africanos foram acusados de feitiçaria por seus vizinhos e parentes. Vários deles haviam sido previamente submetidos a ritos divinatório-judiciários ambundos denominados “juramentos do bulungo” para apurar suas culpas. A partir da análise dos distintos significados da feitiçaria para os agentes eclesiásticos e para os africanos envolvidos (tanto os acusados quanto os acusadores), o artigo evidencia relações de complementaridade e disputa entre diferentes instituições jurídicas africanas e lusitanas. Sugere-se que essas instituições tenham sido estratégica e seletivamente invocadas para resolver disputas ligadas aos direitos de uso da terra por africanos livres em territórios de administração portuguesa.
Palavras-chave: Juramentos do bulungo. Feitiçaria. Inquisição. Angola. religiões africanas.
Autonomia e autoestima no trabalho cerâmico artesanal: reflexões sobre o cooperativismo feminino no bairro Poti Velho, em Teresina – Piauí (2006-2019)
Authors: Silva Amanda Lima da 
Published: May 2022

No presente artigo, fazemos uma análise das experiências de mulheres trabalhadoras ceramistas do Poti Velho, em Teresina – Piauí, com o cooperativismo (2006-2019). Para tanto, usaremos as entrevistas feitas com seis mulheres da Cooperativa de Artesanato do Poti Velho (COOPERART-Poty). Procuramos saber os reflexos do cooperativismo na vida destas mulheres, na formação de suas identidades enquanto trabalhadoras ceramistas e sua contribuição para a renda e autoestima feminina. Percebemos que a COOPERART-Poty possuiu um papel relevante na constituição das identidades femininas como trabalhadoras ceramistas; a produção de peças de argila elevou sua importância econômica em casa; e o trabalho cerâmico na cooperativa contribuiu para o desenvolvimento da autoestima feminina.
Palavras-chave: Trabalho Cerâmico. Cooperativismo. Mulheres.
Формування кроскультурної комунікативної компетенції студентів-філологів
Authors: Малоіван М. В. 
Published: May 2022

У статті з’ясовано проблему формування крос культурної комунікативної компетенції студентів-філологів як важливого чинника виховання майбутніх фахівців в умовах полікультурного світу: визначено роль інтеграції мови та культури, її вплив на міжкультурну комунікацію.
SYSTEMIC APPROACH TO STUDENT LEARNING TECHNICAL UNIVERSITIES
Authors: Mochaliv D.Ye 
Published: May 2022

The application of system approach to training of the technical university students is esteemed. The hierarchic frame of the purposes and subpurposes like “Tree of purposes” as main “gear” of system approach implementation is offered. The "Tree of the purposes” - "Formation of system approach skills at studies of a physics course“ is adduced.
THE PROBLEM OF STUDENT KNOWLEDGE CONTROL AND ACCOUNTING IN THE PRACTICE OF UKRAINIAN NEVER 20s PP. XX CENTURY
Authors: Polishchuk H.P. 
Published: May 2022

The article deals with the methods of control and registration of pupils’ knowledge in the twenties of the last century.
Our research has led us to the conclusion that the new system of methods of control and registration of pupils knowledge was being formed at the time in the Ukrainian school. It united both methods of individual and mass control of pupils’ knowledge.
Special emphasis was made on the methods of control of orthographic ally habits and skills because the problem of literacy of the population of Ukraine (both schoolchildren and grown-ups) was very urgent.
PSYCHOLOGICAL-PEDAGOGICAL CONDITIONS OF DEVELOPMENT SPEECH OF FIRST GRADE STUDENTS BY SMALL MEANS FOLKLORE GENRES
Authors: Kravtsova І.А. , Svincova S.P. 
Published: May 2022

The aims of the lessons in the Ukrainian language, which are enlarging and activization of lexicon, forming and developing of the skills o f oral and written spuch, supplying of the mental development of pupils, are defined on the present stouge of the new junior school's development.
The most important device of influence on a child is beauty and magnificence, power and expressiveness of native words. Children can understand the dupest colour of words through the words the beauty enters their souls.
A Closer Look on Disjunctive Coordination: The So-Called Non-Constituent Disjunctive Coordination
Authors: Lemohang Tjabaka Matlotlisang Mokapane 
Published: May 2022

English disjunctive coordination is a clause complex that has two co-ordinands. Many scholars and researchers dealt with this phenomenon using different standard theories. However, there is still a controversy in literature whether non-constituent coordination exists or not; therefore, this research determines whether the disjunctive coordination constituents are non-constituents. The paper also describes the relationship between the disjunctive co-ordinands, coordinated phrases, or clauses joined by conjunction /or/. The article further aims to describe the structure of the disjunctive coordination and the category label of the disjunctive coordinator. The Systemic Functional Grammar and Minimalist Program framed this study. This qualitative paper purposively and conveniently selected from Facebook and WhatsApp groups for the National University of Lesotho's students; 13 structures were chosen from the WhatsApp group, while 15 were taken from Facebook. Results reveal that the disjunctive coordination constituents are not non-constituents. What seems prevailing or irregular at the Phonetic Form (PF) results from the movement and deletion of duplicate syntactic elements. This deletion of the syntactic features is done to satisfy the economic considerations. It is also reflected that the disjunctive co-ordinands have taxis and logico-semantic type relations or relationships. The paper further divulges that the structure of the disjunctive coordination is the complementiser phrase (CP), and the category label of the disjunctive coordinator/or/ is the complementiser (C). That is, it belongs to the C category.
PHENOTHYPIC DIVERSITY IN 15 WILD POPULATIONS OF TOMATO (Solanum lycopersicum L.)
Authors: LEGARIA SOLANO JUAN PORFIRIO , Alvarado-Rodríguez Rommel I. 
Published: May 2022

RESUMEN
Objetivo: Generar información sobre la variabilidad morfo-agronómica de 15 poblaciones silvestres de tomate, originarias de diferentes zonas de México.
Diseño/metodología/aproximación: Se utilizó un diseño experimental completamente al azar con 17 tratamientos (poblaciones) y 10 repeticiones (individuos). La unidad experimental consistió de una planta (individuo), donde se evaluaron sesenta y cuatro descriptores morfológicos y agronómicos propuestos por Bioversity Internacional. Se realizó un análisis de varianza con medidas repetidas y se comparó las diferencias de medias por la prueba de rangos múltiples Tukey (P ≤ 0.05). Las variables cuantitativas y cualitativas se sometieron a un análisis de componentes principales y de correspondencias múltiple, respectivamente.
Resultados: Se encontró amplia variabilidad en características morfológicas y en atributos de calidad de fruto, como consistencia y sólidos solubles totales. Los análisis de componentes principales y de correspondencia múltiple explicaron la variación fenotípica con 67.41 y 42.06 % en los primeros tres componentes y dimensiones, respectivamente. Las características más discriminantes fueron las de frutos e inflorescencias, que separaron a las poblaciones en cuatro grupos. El primero se integró por plantas con inflorescencias multíparas, con frutos tipo ‘heirloom’ de color rojo y tamaños pequeños a intermedios; el segundo por inflorescencias uníparas y multíparas, con frutos tipo ‘cherry’ y ‘grape’ de colores amarillo, naranja y rojo, y tamaños muy pequeños; el tercero por inflorescencias uníparas y bifurcadas, con frutos tipo bola y ‘cocktail’ de colores rojo, naranja y amarillo, y tamaños pequeños a intermedios; y el cuarto por inflorescencias uníparas, con frutos tipo bola de color morado y tamaños intermedios.
Limitaciones del estudio/implicaciones: Para entender mejor la variabilidad y relaciones filogenéticas de estas poblaciones, se debe realizar una caracterización molecular.
Hallazgos/conclusiones: Todas las poblaciones silvestres mostraron una alta variabilidad fenotípica en las fases vegetativa y reproductiva, siendo las características de fruto e inflorescencia las que más contribuyeron a su discriminación. Las formas de frutos más frecuentes fueron ligeramente aplanadas y redondeadas, y los tamaños de frutos fueron muy pequeños y pequeños. Generalmente, las plantas indeterminadas mostraron grados Brix más altos que las semi determinadas. Los frutos rojos tuvieron Brix más altos que los naranjas, amarillos y morados, pero estos últimos mostraron mejor sabor. Se descubrió un tipo de hoja no reportado en los descriptores para tomate, el cual se denominó ‘con brotes’.
Palabras clave: Solanum lycopersicum L., poblaciones nativas, caracterización morfo-agronómica.
Turismo académico, análisis y perspectivas en Cuba, como parte de las nuevas ofertas de desarrollo turístico.
Authors: Núñez Pérez Wendy 
Published: May 2022

El turismo como actividad económica cobra cada vez más importancia a nivel mundial, en cada una de sus modalidades dándole paso a la satisfacción de cada una de las necesidades de los clientes. Entre esas modalidades se encuentra el Turismo Académico, el cual permite la difusión de conocimientos y prácticas profesionales así como el conocimiento del medio en que se desarrolla, sirviendo como vendedor silencioso del destino. Cuba ha ido potenciando poco a poco esta modalidad, contando con sedes universitarias de excelencia a lo largo de toda la isla, y aprovechando los espacios de intercambio internacional para promocionar los principales cursos. Interesa en este trabajo investigativo abordar el turismo relacionado con la academia, con la formación de las personas en una u otra materia, ya que cada vez es más el número de estudiantes que viajan en busca de conocimientos, nuevas culturas, nuevas fuentes de esparcimiento pero con carácter educativo. Interesa conocer a esta modalidad de manera integrada, sus principales gestores, y estrategias a llevar a cabo para su desarrollo.
Variation of Ozone, Carbon Monoxide, and Oxides of Nitrogen at Bengaluru, India
Authors: Dhanya G. , Pranesha T. S. , Nagaraja K. , Chate D. M. , Beig G. 
Published: May 2022

The present study analyses the continuous in-situ observations of surface ozone (O3), carbon monoxide (CO), and nitrogen oxides (NOX) conducted in an urban location, Bengaluru, India, during the year 2019 (January to December). The seasonal concentration of O3 fluctuated with the highest concentrations in the summer (39.6 ppbv) and winter (40.4 ppbv) and the lowest concentrations during the monsoon (16.8 ppbv). The seasonal mixing ratio of CO showed the highest value in post-monsoon (1.71 ppmv) and lowest during monsoon (0.79 ppmv). The seasonal trend of NOX showed highest in winter (56.8 ppbv) and lowest in monsoon (22.5 ppbv). The monthly mixing ratios of O3, CO, and NOX showed distinct variability, which may be attributed to changing anthropogenic activities, planetary boundary layer processes, and local meteorology. O3 was significantly related to temperature but inversely associated with relative humidity and wind speed. The association between CO, NOX with relative humidity, temperature, wind speed showed discrete results. The (dO3/dt) in the morning and evening duration were about 5.0 ppbv/h and -4.1 ppbv/h respectively.
Study of Different Acid Doped Polyaniline Nanostructures and Their Electrical Conductance Properties
Authors: Kamble R. S. , Patil T. S. , Patil R. P. 
Published: May 2022

The different acid doped polyaniline (PANI) materials were prepared in situ using mineral acids like HCl, H2SO4, HNO3 and HClO4 of different concentrations in presence of 0.2 M aniline solution and 0.25 M ammonium persulfate as oxidising agent by the chemical oxidation method. The synthesized materials were studied for their physico-chemical characterizations like XRD, IR and SEM. IR studies revealed the formation of emeraldine salt in all the acid doped PANI samples. XRD of samples exhibited the partly crystalline structure of which HClO4 doped showed good crystallinity over other samples. SEM images displayed the formation of nanorods like structural agglomerates. The effect of acid dopants on their electrical conductivity was investigated by using the four probe set up technique. It was found that HClO4 doped PANI exhibited good electrical conductivity over the other acid doped samples whereas the lowest electrical conductivity was recorded for HNO3 doped PANI samples. The electrical conductivity of 1 M HClO4 doped PANI was the highest i.e. 9.1 S cm-1 among all PANI samples.
KONTRIBUSI KEWIRAUSAHAAN DALAM MENGURANGI PENGANGGURAN DI DESA SUMI KECAMATAN LAMBU KABUPATEN BIMA
Authors: Nurbayan St. , Muliansyah Ade , Nurnazmi Nurnazmi 
Published: May 2022

Keberadaan kewirausahaan di Desa Sumi memberikan warna tersendiri bagi pengangguran, karena semenjak keberadaan kewirausahaan dapat mengurangi pengangguran di Desa Sumi Kecamatan Lambu Kabupaten Bima. Jenis penelitian yang digunakan adalah penelitian kualitatif deskriptif dengan menggunakan pendekatan kualitatif. Jenis data dalam penelitian menggunakan data primer dan data sekunder, informan kunci sebanyak 8 orang dan 6 informan pendukung. Dalam penentuan informan digunakan tehnik purposive sampling. Tehnik pengumpulan data yakni observasi, wawancara dan dokumentasi. Data yang didapatkan di lapangan di analisis dengan cara reduksi data, display data, dan verifikasi data. Pengujian keabsahan data menggunakan triangulasi tehnik pengumpulan data, triangulasi sumber data, dan triangulasi waktu. Hasil temuan dalam penelitian ini, mengambarkan bahwa dengan keberadaan kewirausahaan dapat mengurangi 43 pengangguran yang ditempatkan pada pelayanan, promosi atau pemasaran dan rata-rata para pekerja merasa nyaman dengan pola kerja yang ditentukan oleh pemilik CV kewirausahaan dan upanya sangat sesuai dengan standar UMR Kota dan Kabupaten Bima. Selain itu, terdorongnya pertumbuhan ekonomi Desa, meningkatnya pendapatan masyarakat serta berkurangnya pengangguran.
KEMITRAAN PENDAMPING DESA DAN PEMERINTAH DESA UNTUK DESA TERPENCIL DI DESA KARAMPI KECAMATAN LANGGUDU KABUPATEN BIMA
Authors: Tahir M. , Darwis Darwis , Arifuddin Arifuddin , Nurbayan St. 
Published: May 2022

Pendamping Desa dan pemerintah Desa merupakan dua pranata yang memiliki tujuan yang sama untuk membangun desa kearah yang lebih baik, maka pendamping desa Mendampingi desa dalam perencanaan pembangunan dan keuangan desa, tujuannya agar perencanaan dan penganggaran desa berjalan sesuai aturan dan ketentuan yang berlaku berdasarkan indikator output yang ada. :sebuah wadah yang hasil penelitian partisipasi pendamping desa dan pendamping. Kemudian salah satu agendanya mengawal implementasi UU No. 6 Tahun 2014 tentang Desa, secara sistematis, konsisten dan berkelanjutan dengan fasilitasi, supervisi, dan pendampingan. Namun kurangnya peranserta dan kemitraan pendamping desa dan pemerintah desa serta masyarakat desa karena dalam kegiatan perencanaan, pelaksanaan, dan pengendalian pembangunan desa serta pelestarian hasil-hasil pembangunan, 1. kurangnya kesadaran penuh dari pendamping desa dan pemerintah desa untuk musyawarah dan keterbukaan dalam merancang dan melaksanakan pembangunan Desa, 2. Masyarakat desa semata-mata diposisikan sebagai objek atau sasaran pembangunan, 3. Kemitraan pemerintah desa dan pendamping desa masih sebatas pada output atau pemanfaatan hasil, 4. Secara umum banyak potensi alam yang masih dikelola dengan baik, 5. kecenderungan sifat penduduk desa yang menerima kondisi apa adanya. 6. SDM masyarakat masih pendidikan tingkat menengah ke bawah.