bluuebunny/crossref_metadata_2025_split huggingface dataset:
Genome-wide identification of quantitative trait loci for morpho-agronomic and yield-related traits in foxtail millet (Setaria italica) across multi-environments
Authors: Liu Tianpeng , He Jihong , Dong Kongjun , Wang Xuewen , Zhang Lei , Ren Ruiyu , Huang Sha , Sun Xiaoting , Pan Wanxiang , Wang Wenwen , Yang Peng , Yang Tianyu , Zhang Zhengsheng 
Published: April 2022

AbstractFoxtail millet (Setaria italica) is an ideal model of genetic system for functional genomics of the Panicoideae crop. Identification of QTL responsible for morpho-agronomic and yield-related traits facilitates dissection of genetic control and breeding in cereal crops. Here, based on a Yugu1 × Longgu7 RIL population and genome-wide resequencing data, an updated linkage map harboring 2297 bin and 74 SSR markers was constructed, spanning 1315.1 cM with an average distance of 0.56 cM between adjacent markers. A total of 221 QTL for 17 morpho-agronomic and yield-related traits explaining 5.5 ~ 36% of phenotypic variation were identified across multi-environments. Of these, 109 QTL were detected in two to nine environments, including the most stable qLMS6.1 harboring a promising candidate geneSeita.6G250500, of which 70 were repeatedly identified in different trials in the same geographic location, suggesting that foxtail millet has more identical genetic modules under the similar ecological environment. One hundred-thirty QTL with overlapping intervals formed 22 QTL clusters. Furthermore, six superior recombinant inbred lines, RIL35, RIL48, RIL77, RIL80, RIL115 and RIL125 with transgressive inheritance and enrichment of favorable alleles in plant height, tiller, panicle morphology and yield related-traits were screened by hierarchical cluster. These identified QTL, QTL clusters and superior lines lay ground for further gene-trait association studies and breeding practice in foxtail millet.
Säntis lightning research facility: a summary of the first ten years and future outlook
Authors: Rachidi Farhad , Rubinstein Marcos 
Published: April 2022

AbstractThe Säntis Tower was instrumented in May 2010 to measure currents of lightning discharges striking the structure. Since then, the system has been recurrently updated and expanded. Presently, data associated with lightning striking the tower are collected at six different sites. The facility is equipped with a current measurement system, three electric field stations, an electrostatic field mill, two x‑ray sensors, a high-speed camera, and four slow cameras. This paper presents the latest measurement configuration at the facility. Other temporarily loaned instruments are also briefly described. Furthermore, examples of some of the data that have been gathered and analyzed are given, and an outlook as well as future plans for the facility are presented.
The effect of zinc supplementation on glucose homeostasis: a randomised double-blind placebo-controlled trial
Authors: Attia John R. , Holliday Elizabeth , Weaver Natasha , Peel Roseanne , Fleming Kerry C. , Hure Alexis , Wiggers John , McEvoy Mark , Searles Andrew , Reeves Penny , Ranasinghe Priyanga , Jayawardena Ranil , Samman Samir , Luu Judy , Rissel Chris , Acharya Shamasunder 
Published: April 2022

Abstract
Aims
The burden and health costs of Type 2 Diabetes Mellitus continue to increase globally and prevention strategies in at-risk people need to be explored. Previous work, in both animal models and humans, supports the role of zinc in improving glucose homeostasis. We, therefore, aimed to test the effectiveness of zinc supplementation on glycaemic control in pre-diabetic adults.

Methods
We conducted a randomized, double-blind, placebo-controlled trial across 10 General Practitioner (GP) practices in NSW, Australia. The trial is known as Zinc in Preventing the Progression of pre-Diabetes (ZIPPeD)Study. Pre-diabetic (haemoglobin A1c [HbA1c] 5.7–6.4%, 39–46 mmol/mol) men and women (N = 98) were all assigned to a free state government telephone health coaching service (New South Wales Get Healthy Information and Coaching Service) and then randomised to either daily 30 mg zinc gluconate or placebo. Blood tests were collected at baseline, 1, 6 and 12 months for the primary outcomes (HbA1c, fasting blood glucose (FBG)); secondary outcomes included Homeostasis Model Assessment 2 (HOMA 2) parameters, lipids, body weight, height, waist circumference, blood pressure and pulse.

Results
The baseline-adjusted mean group difference at 6 months, expressed as treatment–placebo, (95% CI) was −0.02 (−0.14, 0.11, p = 0.78) for HbA1c and 0.17 (−0.07, 0.42; p = 0.17) for FBG, neither of which were statistically significant. There were also no significant differences between groups in any of the secondary outcomes. Zinc was well tolerated, and compliance was high (88%).

Conclusion
We believe our results are consistent with other Western clinical trial studies and do not support the use of supplemental zinc in populations with a Western diet. There may still be a role for supplemental zinc in the developing world where diets may be zinc deficient.

Trial registration
Australian and New Zealand Clinical Trials Registry, ACTRN12618001120268. Registered on 6 July 2018.
Isolation of Hermetia illucens larvae core gut microbiota by two different cultivation strategies
Authors: Cifuentes Yina , Vilcinskas Andreas , Kämpfer Peter , Glaeser Stefanie P. 
Published: April 2022

AbstractHermetia illucenslarvae (black soldier fly larvae, BSFL) convert efficiently organic waste to high quality biomass. To gain knowledge on the specific functions of gut microbes in this process it is a prerequisite to culture members of the core gut microbiota. Two different cultivation strategies were applied here for this purpose, a dilution-to-extinction cultivation and direct plating using six different media to culture aerobic heterotrophic bacteria. A total of 341 isolates were obtained by the dilution-to-extinction cultivation and 138 isolates by direct plating from guts of BSFL reared on chicken feed. Bacterial isolates were phylogenetically identified at the genus level by 16S rRNA gene sequencing (phylotyping) and differentiated at the strain level by genomic fingerprinting (genotyping). The main proportion of isolates was assigned toProteobacteria,Firmicutes(Bacilli), andActinobacteria.Predominant genera discussed in literature as member of a potential BSFL core gut microbiota,Providencia, Proteus, Morganella, Enterococcus, Bacillus,and members of the familyEnterobacteriaceae, were isolated. A high intra-phylotype diversity was obtained by genomic fingerprinting which was especially enhanced by the dilution-to-extinction cultivation. This study showed that the application of different cultivation strategies including a dilution-to-extinction cultivation helps to culture a higher diversity of the BSFL gut microbiota and that genomic fingerprinting gives a better picture on the genetic diversity of cultured bacteria which cannot be covered by a 16S rRNA gene sequence based identification alone.
Earthquake hazard and risk analysis for natural and induced seismicity: towards objective assessments in the face of uncertainty
Authors: Bommer Julian J. 
Published: April 2022

AbstractThe fundamental objective of earthquake engineering is to protect lives and livelihoods through the reduction of seismic risk. Directly or indirectly, this generally requires quantification of the risk, for which quantification of the seismic hazard is required as a basic input. Over the last several decades, the practice of seismic hazard analysis has evolved enormously, firstly with the introduction of a rational framework for handling the apparent randomness in earthquake processes, which also enabled risk assessments to consider both the severity and likelihood of earthquake effects. The next major evolutionary step was the identification of epistemic uncertainties related to incomplete knowledge, and the formulation of frameworks for both their quantification and their incorporation into hazard assessments. Despite these advances in the practice of seismic hazard analysis, it is not uncommon for the acceptance of seismic hazard estimates to be hindered by invalid comparisons, resistance to new information that challenges prevailing views, and attachment to previous estimates of the hazard. The challenge of achieving impartial acceptance of seismic hazard and risk estimates becomes even more acute in the case of earthquakes attributed to human activities. A more rational evaluation of seismic hazard and risk due to induced earthquakes may be facilitated by adopting, with appropriate adaptations, the advances in risk quantification and risk mitigation developed for natural seismicity. While such practices may provide an impartial starting point for decision making regarding risk mitigation measures, the most promising avenue to achieve broad societal acceptance of the risks associated with induced earthquakes is through effective regulation, which needs to be transparent, independent, and informed by risk considerations based on both sound seismological science and reliable earthquake engineering.
eCBT Versus Standard Individual CBT for Paediatric Obsessive–Compulsive Disorder
Authors: Babiano-Espinosa Lucía , Skarphedinsson Gudmundur , Weidle Bernhard , Wolters Lidewij H. , Compton Scott , Ivarsson Tord , Skokauskas Norbert 
Published: April 2022

AbstractObsessive–compulsive disorder (OCD) is characterized by recurring obsessions and compulsions often with severe impairment affecting 1–3% of children and adolescents. Cognitive behavioural therapy (CBT) is the therapeutic golden standard for paediatric OCD. However, face-to-face CBT is limited by accessibility, availability, and quality of delivery. Enhanced CBT (eCBT) a combination of face-to-face sessions at the clinic and treatment at home via webcam and a supportive app system aims to address some of these barriers. In this pilot study, we compared eCBT outcomes of 25 paediatric patients with OCD benchmarked against traditional face-to-face CBT (n = 269) from the Nordic Long-term OCD Treatment Study, the largest paediatric OCD CBT study to date. Pairwise comparisons showed no difference between eCBT and NordLOTS treatment outcomes. Mean estimate difference was 2.5 in favour of eCBT (95% CI − 0.3 to 5.3). eCBT compared to NordLOTS showed no significant differences between response and remission rates, suggesting similar effectiveness.
Validity of the SNAP-IV For ADHD Assessment in South African Children With Neurodevelopmental Disorders
Authors: Zieff Michal R. , Hoogenhout Michelle , Eastman Emma , Christ Björn U. , Galvin Alice , de Menil Victoria , Abubakar Amina , Newton Charles R. , Robinson Elise , Donald Kirsten A. 
Published: April 2022

AbstractThis study investigated the psychometric properties of the Swanson, Nolan, and Pelham ADHD Rating Scale (SNAP-IV) in a sample of South African children with neurodevelopmental disorders (n = 201), primarily Autism Spectrum Disorder and Intellectual Disability. We conducted a confirmatory factor analysis to inspect the two-factor structure of the SNAP-IV. We also calculated ordinal coefficient alpha to estimate internal consistency. Fit statistics for the two-factor model approached acceptable levels. The model fit improved slightly after removing an item related to spoken language. The subscales had acceptable internal consistencies. Findings partially support the use of the SNAP-IV in this group of children. However, there are limitations to its performance in this population likely related to the presence of neurodevelopmental disorders.
Intraoperative hypothermia in the neonate population: risk factors, outcomes, and typical patterns
Authors: Zhang Man-Qing , Ying Peng-Dan , Wang Yu-Jia , Zhao Jia-lian , Huang Jin-Jin , Gong Fang-Qi 
Published: April 2022

AbstractThe risk factors, outcomes, and typical patterns of intraoperative hypothermia were studied in neonates to better guide the application of insulation measures in the operating room. This retrospective study enrolled 401 neonates undergoing surgery under general anaesthesia with tracheal intubation, including abdominal surgery, thoracic surgery, brain surgery, and others. The study collected basic characteristics, such as age, sex, weight, birth weight, gestational week, primary diagnosis and American Society of Anaesthesiologists (ASA) grade. Perioperative data included preoperative body temperature, length of hospital stay, length of intensive care unit (ICU) stay, intubation time, postoperative bleeding, postoperative pneumonia, postoperative death, and total cost of hospitalization. Intraoperative data included surgical procedures, anaesthesia duration, operation duration, blood transfusion, fluid or albumin infusion, and application of vasoactive drugs. The incidence of intraoperative hypothermia (< 36 °C) was 81.05%. Compared to normothermic patients, gestational week (OR 0.717; 95% CI 0.577–0.890; P = 0.003), preoperative temperature (OR 0.228; 95% CI 0.091–0.571; P = 0.002), duration of anaesthesia (OR 1.052; 95% CI 1.027–1.077; P < 0.001), and type of surgery (OR 2.725; 95% CI 1.292–5.747; P = 0.008) were associated with the risk of intraoperative hypothermia. Patients with hypothermia had longer length of ICU stay (P = 0.001), longer length of hospital stay (P < 0.001), and higher hospital costs (P < 0.001). But there were no association between clinical outcomes and intraoperative hypothermia in the multivariable regression adjusted analysis. The lowest point of intraoperative body temperature was approximately 1 h 30 min. Then, the body temperature of patients successively entered a short plateau phase and a period of slow ascent. The greatest decrease in body temperatures occurred in preterm babies and neonates with preoperative hypothermia. The lowest core temperatures that occurred in neonates with preoperative hypothermia was lower than 35 °C. This study shows that there is a high incidence of intraoperative hypothermia in the neonate population. The intraoperative body temperature of neonates dropped to the lowest point in 1–1.5 h. The greatest decrease in core temperatures occurred in preterm babies and neonates with lower preoperative temperature.
Effects of Social Context on Deliberate Facial Expressions: Evidence from a Stroop-like Task
Authors: Katembu Stephen , Xu Qiang , Rostami Hadiseh Nowparast , Recio Guillermo , Sommer Werner 
Published: April 2022

AbstractFacial expressions contribute to nonverbal communication, social coordination, and interaction. Facial expressions may reflect the emotional state of the expressor, but they may be modulated by the presence of others, for example, by facial mimicry or through social display rules. We examined how deliberate facial expressions of happiness and anger (smiles and frowns), prompted by written commands, are modulated by the congruency with the facial expression of background faces and how this effect depends on the age of the background face (infants vs. adults). Our main interest was whether the quality of the required expression could be influenced by a task-irrelevant background face and its emotional display. Background faces from adults and infants displayed happy, angry, or neutral expressions. To assess the activation pattern of different action units, we used a machine classifier software; the same classifier was used to assess the chronometry of the expression responses. Results indicated slower and less correct performance when an incongruent facial expression was in the background, especially when distractor stimuli showed adult faces. Interestingly, smile responses were more intense in congruent than incongruent conditions. Depending on stimulus age, frown responses were affected in their quality by incongruent (smile) expressions in terms of the additional activation or deactivation of the outer brow raiser (AU2), resulting in a blended expression, somewhat different from the prototypical expression for anger. Together, the present results show qualitative effects on deliberate facial expressions, beyond typical chronometric effects, confirming machine classification of facial expressions as a promising tool for emotion research.
Copy-move image forgery detection based on evolving circular domains coverage
Authors: Lu Shilin , Hu Xinghong , Wang Chengyou , Chen Lu , Han Shulu , Han Yuejia 
Published: April 2022

AbstractThe aim of this paper is to improve the accuracy of copy-move forgery detection (CMFD) in image forensics by proposing a novel scheme and the main contribution is evolving circular domains coverage (ECDC) algorithm. The proposed scheme integrates both block-based and keypoint-based forgery detection methods. Firstly, the speed-up robust feature (SURF) in log-polar space and the scale invariant feature transform (SIFT) are extracted from an entire image. Secondly, generalized 2 nearest neighbor (g2NN) is employed to get massive matched pairs. Then, random sample consensus (RANSAC) algorithm is employed to filter out mismatched pairs, thus allowing rough localization of counterfeit areas. To present these forgery areas more accurately, we propose the efficient and accurate ECDC algorithm to present them. This algorithm can find satisfactory threshold areas by extracting block features from jointly evolving circular domains, which are centered on matched pairs. Finally, morphological operation is applied to refine the detected forgery areas. Experimental results indicate that the proposed CMFD scheme can achieve better detection performance under various attacks compared with other state-of-the-art CMFD schemes.
Fundamental diagram of urban rail transit considering train–passenger interaction
Authors: Seo Toru , Wada Kentaro , Fukuda Daisuke 
Published: April 2022

AbstractUrban rail transit often operates with high service frequencies to serve heavy passenger demand during rush hours. Such operations can be delayed by two types of congestion: train congestion and passenger congestion, both of which interact with each other. This delay is problematic for many transit systems, since it can be amplified due to the interaction. However, there are no tractable models describing them; and it makes difficult to analyze management strategies of congested transit systems in general and tractable ways. To fill this gap, this article proposes simple yet physical and dynamic model of urban rail transit. First, a fundamental diagram of transit system (i.e., theoretical relation among train-flow, train-density, and passenger-flow) is analytically derived considering the aforementioned physical interaction. Then, a macroscopic model of transit system for dynamic transit assignment is developed based on the fundamental diagram. Finally, accuracy of the macroscopic model is investigated by comparing to microscopic simulation. The proposed models would be useful for mathematical analysis on management strategies of urban rail transit systems, such as optimal dynamic pricing for travel demand management.
Enhancement of Organic Solar Cells Through Macroscopic and Microscopic Models
Authors: Zidan Mahmoud N. , Ismail Tawfik , Kassem Sally S. , Wahdan Hayam G. , Fahim Irene S. 
Published: April 2022

Abstract
Organic solar cells performance enhancement is driven by improvements in device parameters. Compared to conventional silicon-based devices, the photo-generation process in organic devices is more complicated. This work investigates the possibility of improving the device performance theoretically by inserting microscopic parameters such as mobility, recombination factor, generation rate, and carriers density into the macroscopic single diode model. A proper selection of parameters leads to enhancement in $$(V_{oc}, I_{sc})$$

(

V

oc

,

I

sc

)

and (FF) while others should be avoided. A compromise between accuracy and speed can be achieved. Balanced mobility enhances short circuit current and the open-circuit voltage while higher values of ideality factor inhibit device performance.

Graphical Abstract
Defect-Correlated Vickers Microhardness of Al-Si-Mg Alloy Manufactured by Laser Powder Bed Fusion with Post-process Heat Treatments
Authors: Cerri Emanuela , Ghio Emanuele , Bolelli Giovanni 
Published: April 2022

AbstractLaser powder bed fusion is an additive manufacturing process characterized by different advantages like the manufacture of samples with complex geometry without the use of tools and/or molds. Generally, the manufactured samples are characterized by high tensile strengths which, however, can be affected by the presence of defects due to the unoptimized process parameters. In a large applications field, a low density of the as-built AlSi10Mg samples is a very important parameter to considered, e.g., due to both the loss of the tensile strengths correlated with a premature failure of the samples and the increase in time and costs associated with the manufacturing process. In addition, different post-process heat treatments can increase these effects leading to an ineffective manufacturing process. In this scenario, the present work shows the analysis of spherical and lack-of-fusion pores induced by the laser powder bed fusion process on the AlSi10Mg samples and their variations after different heat treatments (direct aging and T6). At the same time, the influence of pores on the Vickers microhardness and the tensile properties has been studied in the same AlSi10Mg samples (bars and billets) that were printed with single- and double-laser machine setup. Different process parameters were also analyzed and compared. The study was supported by the microstructural and pore analysis performed by optical microscopy along the XZ plane (build direction) and the XY plane. Finally, the greatest effects of pores were observed on the Vickers microhardness values; in fact, two different relationships between microhardness and density variation are discussed. The T6 heat treatment leads to a rounding of the pores already formed in the as-built samples and to a formation of new small pores.

Graphical Abstract
The interaction between phenylboronic acid derivatives and active ingredients with diphenol structure of traditional Chinese medicine
Authors: Wu Yi , Fu Yifu , Fu Yao , Li Bing , Liu Chang , Pan Peng , Lan Tianyu , Shen Xiangchun , Guo Qianqian 
Published: April 2022

AbstractMany active ingredients of traditional Chinese medicine with important pharmacological effects always have glycol or diphenol structure, which lays a foundation for the combination with phenylboronic acid (PBA) derivatives to form cyclic boronic esters compounds. Herein, four important pharmacological active ingredients, namely baicalein, baicalin, gallic acid and protocatechuic acid, were chosen to study the interaction with PBA derivatives. Five PBA derivatives of 3-aminophenylboronic acid monohydrate (APBA), 3-acrylaminophenylboronic acid (AAPBA), poly(3-acrylaminophenylboronic acid) (PAAPBA), poly([poly(ethylene glycol) methacrylate-block-3-acrylaminophenylboronic acid]) (PEbPB), and poly[poly(ethylene glycol) methacrylate-random-3-acrylaminophenylboronic acid] (PErPB) were used. The interactions between five PBA derivatives and four active ingredients were explored by fluorescent spectrophotometer using the alizarin red (ARS) method. The fluorescent intensity of PBA derivative-ARS-active ingredient mixture was decreasing with the increasing concentrations of active ingredients. In comparison, the fluorescent intensity of PAAPBA, PEbPB, and PErPB showed an obviously decrease after active ingredients were added, while the fluorescent intensity of APBA and AAPBA showed a gradually decrease after active ingredients were added. These results indicated a stronger interaction between PBA polymers and active ingredients than that of APBA and AAPBA. Simultaneously, PEbPB and PErPB could enhance cellular uptake of baicalin in A549 cells. This research provided new strategies for improving the bioavailability and water solubility, extending the circulation time, and wider application of the active ingredients of traditional Chinese medicine in the prevention and therapy of diseases.