bluuebunny/crossref_metadata_2025_split huggingface dataset:
An observational study of Helicobacter pylori infection in patients with chronic plaque psoriasis
Authors: Anas Mohammed , Arora Tarlok C. , Gaind Rajni , Matlani Monika 
Published: May 2022

Objectives
To determine the prevalence of Helicobacter pylori infection in patients with chronic plaque psoriasis and to determine the association of H. pylori infection with the severity of chronic plaque psoriasis.

Patients and methods
The prospective case–control pilot study was conducted in the outpatient Department of Dermatology from November 2017 to April 2019. A total of 50 patients with chronic plaque psoriasis and 50 consenting healthy controls were included in the study. A cutaneous examination of the morphology, site, and extent of the lesions was done. Psoriasis area and severity index scores were calculated for all patients. H. pylori stool antigen test was performed for all cases and controls. The data were entered into MS Excel spreadsheet, and analysis was done using the Statistical Package for the Social Sciences (SPSS), version 21.0.

Results
The mean age of patients with psoriasis was 37.24±11.7 years, with 64% males and 36% females. H. pylori was positive in 24/50 patients with psoriasis. Compared with controls, patients with psoriasis had significantly higher H. pylori positivity rate (48 vs. 26%, P=0.023). Compared with the patients with H. pylori negative status (n=26), H. pylori positivity (n=24) showed significant association with site and disease progression (P=0.016) but not with disease duration (P=0.907). The median psoriasis area and severity index score in H. pylori-positive patients was significantly higher than that in patients with negative H. pylori (13.55 vs. 4.65, P=0.002).

Conclusion
The small number of patients studied showed that H. pylori infection is associated with psoriasis, with the progression and the severity of psoriasis, bearing a direct association with increased positivity for H. pylori.
Tissue and serum lipoxin A4 levels in psoriasis patients and their relation with disease severity
Authors: Naguib Rehab Mohamed , Al Nemr Hanan Abo Zaid Mohamed , Rashed Laila Ahmed , Naguib Reham William 
Published: May 2022

Background
Psoriasis disease is a chronic hyperproliferative inflammatory disease, in which genetic and environmental factors have an important role, but the exact cause is yet unknown. Lipoxin A4 plays a role in improvement of psoriasis cases, it blocks the production of the proinflammatory cytokine tumor necrosis factor with increasing the production of the anti-inflammatory cytokine, c–c chemochine receptor-5 by T lymphocytes, and it reduces the perception of pain due to inflammation.

Aim
Detection of the expression of lipoxin A4 in the tissue and serum of psoriatic patients as compared with normal-control persons to investigate the possible role of lipoxin A4 in the psoriasis pathogenesis and its correlation with disease severity.

Patients and methods
The present study included 25 psoriatic patients and 25 age, sex-matched healthy controls. Four-mm punch-skin biopsy was taken from patients (psoriatic lesion) and control persons and it was kept in lysis solution for the stability of the studied parameters and it was kept frozen at –80°C till analysis of lipoxin A4 by PCR. Peripheral blood samples for detection of serum lipoxin A4 were taken. Blood samples were centrifuged and the serum was stored at –80°C and used for enzyme-linked immunosorbent assay.

Results
Psoriatic patients had significantly lower tissue and serum lipoxin A4 levels as compared with normal-control persons.

Conclusions
Lipoxin A4 could contribute to psoriasis pathogenesis through its immunomodulatory role.
Autophagy-related gene 16L1 value in chronic plaque psoriasis
Authors: Naguib Rehab M. , El-Rifaie Abd-El Aziz , Eissa Eman A.Z. , Rashed Laila A. 
Published: May 2022

Background
Psoriasis is a chronic hyperproliferative inflammatory disease, in which genetic and environmental factors have an important role, but the exact cause is yet unknown. Autophagy is a strictly regulated lysosomal degradation pathway that is crucial for maintaining intracellular homeostasis and normal development. Dysregulation of autophagy-related genes has been recognized to increase susceptibility to diseases, such as inflammation, cancer, and autoimmune disorders.

Aim
Our study aimed to detect the expression of the autophagy-related gene 16L1 (ATG 16L) in psoriasis patients compared with normal controls to investigate the role of autophagy in the pathogenesis of this disease.

Patients and methods
This case–control study included 30 psoriasis patients and 30 healthy controls. Punch skin biopsies of 4 mm were taken from psoriatic lesions and then from the controls and they were kept in a lysis solution for the stability of the studied parameters and were kept frozen at –80°C till analysis of ATG 16L using real-time PCR.

Results
The level of the ATG 16L1 in the lesional skin of psoriasis was significantly increased compared with normal controls (P<0.001).

Limitation
Limited number of patients were included in this study (30 patients).

Conclusion
Autophagy process may play an important role in the pathogenesis of psoriasis disease.
Assessment of serum fatty acid-binding protein 4 and adiponectin levels in psoriasis patients and their correlation with disease severity
Authors: Tawfik Noha Z. , Gomaa Amal H.A. , Hassan Ranya , El-alfy Basma A. , Rageh Sara A. , Ismail Nader A. 
Published: May 2022

Background
Psoriasis is a chronic multifactorial autoimmune disease that has significant impacts on the quality of life. Adiponectin exhibits important anti-inflammatory, antioxidants, and antidiabetic effects. The role of fatty acid-binding protein 4 (FABP4) in psoriasis may be linked to tumor necrosis factor-α, which is one of the main cytokines contributing to the etiopathogenesis of this disease.

Aim
To understand the role of serum levels of FABP4 and adiponectin in disease pathogenesis and their correlation to disease severity.

Patients and methods
A case–control study was conducted on two groups. The first group included 35 psoriatic patients; the second group included 35 healthy volunteers matched for age, sex, and weight. Serum FABP4 and adiponectin levels were evaluated.

Results
The mean level of adiponectin among the patients was 4.3±1.4 ng/dl. The mean level of FABP4 among controls was 2.1±1.5 ng/dl. The difference between both groups was statistically significant (P<0.05).

Conclusion
In this study, serum FABP4 level and adiponectin levels were decreased in patients with psoriasis with no relation to disease severity. So, they cannot be used as clinical biomarkers of inflammation and disease activity in psoriasis
Evaluation of the Ameliorative Roles of Vitamins A, C, and E on Alanine Aminotransferase Production in Clarias gariepinus (Burchell, 1822) Fingerlings Exposed to Lead Nitrate
Authors: Samuel Patrick Ozovehe , Arimoro F. O. , Ayanwale A. V. , Mohammad H. L. 
Published: May 2022

Background:
Pollutants from industrial and commercial usage of chemicals all over the world that usually lead to release of myriads of toxic pollutants such as lead call for concern.

Aim and Objective:
The effects of lead nitrate on the production of antioxidants such as Alanine aminotransferase (ALT) in Clarias gariepinus and how such effects can be ameliorated through administration of vitamins were investigated.

Materials and Methods:

C. gariepinus fingerlings (whose initial weight ranged from 3 to 11 g) were exposed to sublethal concentrations of Pb (00, 26 mg/L, 44 mg/L, 61 mg/L, and 79 mg/L) with replicate in each case. 26 mg/L of the vitamins was administered across all bud. Fresh concentrations of both toxicant and vitamins were administered every 72 h for a period of 12 weeks every time the water medium was changed. The various treatments group include Pb (Pb only), PbVA (Pb + vitamin A), PbVC ((Pb + vitamin C), and PbVE (Pb + vitamin E) with T1-T4 and replicates in each case. Three samples of the fish were randomly selected and sacrificed from each aquarium tank every 2 weeks of the exposure period. The gills, kidneys, and liver were excised from these specimens and homogenized in sodium phosphate buffer. These were then assayed for ALT production levels in each case. The data generated were subjected to one-way analysis of variance and considered significant at P ≤ 0.05.

Results:
In samples exposed to Pb only group, the ALT production levels indicated that the highest ALT produced in the liver, kidney, and gills was 87.20 ± 0.15 nM/mg, 65.76 ± 0.20 nM/mg, and 69.92 ± 0.05 nM/mg, respectively. Samples exposed to PbVA indicated that the highest ALT produced in the liver, kidney, and gills was 77.12 ± 0.20 nM/mg, 84.75 ± 0.10 nM/mg, and 70.43 ± 0.24 nM/mg, respectively.

Conclusions and Recommendation:
In samples exposed to PbVC, the highest ALT produced in the liver, kidney, and gills was 86.53 ± 0.05 nM/mg, 63.48 ± 0.15 nM/mg, and 66.53 ± 0.15 nM/mg, respectively. In samples exposed to PbVE, the highest ALT produced in the liver, kidney, and gills was 73.82 ± 0.15 nM/mg, 78.05 ± 0.15 nM/mg, and 73.31 ± 0.05 nM/mg, respectively. The samples of the fish exposed to sublethal concentrations of the toxicant in the various treatments displayed varying levels of production of the enzyme with higher production levels mostly at higher concentrations of the toxicant. In the Pb only and PbVC groups, the liver of the samples produced the highest ALT, while the kidneys did same in the PbVA and PbVE groups. The high levels of production of the enzyme, especially in higher concentrations suggest physiological imbalances due to the presence of the toxicant.
Effects of Zingiber officinale Aqueous Leaf Extract on Vincristine-Induced Kidney Damage in Adult Wistar Rats
Authors: Ehimigbai Richard O. Agbonluai , Akpobaro Afokeoghene Eseoghene 
Published: May 2022

Background:
Vincristine, although used as a chemotherapy drug, has been reported to induce nephrotoxicity, while Zingiber officinale, a medicinal plant, possesses antioxidant, antiapoptotic, and antitumorigenic properties.

Aim and Objectives:
In this study, we examined the effects of Z. officinale against vincristine-induced kidney damage by analyzing renal function, enzymatic antioxidants, and renal tissue.

Materials and Methods:
Thirty adult Wistar rats, weighing between 140 g and 185 g, were assigned into six groups of five animals each. Groups A, B, C, D, E, and F received 1 ml of distilled water, 200 mg/kg of Z. officinale aqueous extract, 1000 mg/kg of Z. officinale aqueous extract, 50 μg/kg of vincristine only, 200 mg/kg of Z. officinale aqueous extract and 50 μg/kg of vincristine, and 1000 mg/kg of Z. officinale aqueous extract and 50 μg/kg of vincristine, respectively. Administration of vincristine was by a 10-day intraperitoneal injection, while that of Z. officinale was by gavage, for a period of 28 days. Food and water were provided across all groups, ad libitum.

Results:
Vincristine significantly (P < 0.05) increased the levels of creatinine, urea, chloride, and malondialdehyde while having a reducing effect on the levels of superoxide dismutase and catalase. The histology revealed that vincristine caused a distortion of the renal architecture.

Conclusion:
The administration of Z. officinale mitigated the aforementioned debilitating effects of vincristine.
Antifibrotic Potential of Tetracarpidium conophorum (African Walnut) Leaves Extract on Diethylstilbestrol-Induced Rat Model of Uterine Fibroid
Authors: Oyinloye Esther Y. , Alabi Mutiu A. , Ajayi Kofoworola , Ajose Dolapo , Adeyemi Ayobola B. , Ajani Emmanuel O. 
Published: May 2022

Background:
The increased prevalence of uterine fibroid (UF) and its life-threatening impact among women of reproductive age led to the development of this study. The study investigated the antifibrotic potential of Tetracarpidium conophorum aqueous extract on UF-induced rats.

Materials and Methods:
Sixty-four female Wistar rats, with an average weight of 200 g, were used for the study. The rats were randomly divided into eight groups of eight animals each. UF was induced by oral administration of diethylstilbestrol (DES) and intramuscular injection of progesterone at dosages 1.35 and 1.0 mg/kg body weight, respectively. Group 1 was administered normal saline orally for 8 weeks. Groups 2 and 3 were treated with progesterone and a combination of DES and progesterone, respectively. Groups 4 and 5 were pretreated with 200 and 400 mg/kg T. conophorum extract, respectively, for 3 weeks before the administration of DES and progesterone for 5 weeks. Groups 6 and 7 were administered DES and progesterone for 5 weeks before being treated with 200 and 400 mg/kg T. conophorum extract, respectively, for 3 weeks. Group 8 was the self-recovery group-administered DES and progesterone for 5 weeks after which they were given normal saline orally for 3 weeks.

Results:
After the treatment period, the rats were euthanized, and blood was collected, while the uteruses were harvested. Co-administration of DES and progesterone produces UF conditions. However, pre- and post-treatment with 200 mg/kg of extract mitigated the effects that were induced by DES and progesterone, but no remarkable preventive and curative effects were observed with the higher dosage (400 mg/kg). There were a reduction of the serum prolactin level in the treatment groups and an increased serum progesterone level in the posttreatment group.

Conclusion:
The study has shown that T. conophorum has both preventive and curative effects on UF at low dosage (200 mg/kg).
A complete review on floating drug delivery system
Authors: Chauhan Priyanshi , Kumar Kapil , Khairiya Dipti , Teotia Deepak 
Published: May 2022

The aim of writing this review on FDDS to focus on the system of floatation to attain gastric retention, or to attain desired concentration of drug in blood or tissues. Today’s condition focus on the formulation of the FDDS. Effervescent FDDS release carbon dioxide gas, thus decreases the density of the system and remain floatable in stomach for a longer period of time and released the drug at slowly conveniently in order to improve bioavailability of drug. The study summarizes the application of the system, factors that affect floating system, mechanism, advantages, disadvantages and preparation.
KARAKTERISTIK DAN ANALISIS KEKERABATAN RAGAM SERTA PEMANFAATAN TANAMAN KELAPA (Cocos nucifera) OLEH MASYARAKAT DI DESA SUNGAI SORIK DAN DESA RAWANG OGUNG KECAMATAN KUANTAN HILIR SEBERANG KABUPATEN KUANTAN SINGINGI
Authors: Riono Yoyon , Marlina Marlina , Yusuf Elfi Yenny , Apriyanto Mulono , Novitasari Rifni , Mardesci Hermiza 
Published: May 2022

Research on the characteristics and analysis of kinship diversity and the use of coconut (Cocos nucifera L.) in Sungai Sorik and Rawang Ogung villages has been carried out to find out there are several varieties, kinship relationships, and benefits of coconut (Cocos nucifera L.). Exploration of coconut (Cocos nucifera L.) was carried out in Sungai Sorik and Rawang Ogung Villages. Plant Development Structure, carried out February-July 2021. The research method used exploration and observation and measurements of plant parts to make a description of coconut (Cocos nucifera L.). The results of morphological and anatomical observations in the form of qualitative and quantitative data. The results showed that there were three varieties of coconut (Cocos nucifera L.) namely deep coconut (pelak/polak), early coconut (superior), and yellow coconut.

Penelitian tentang karakteristik dan analisis kekerabatan ragam serta pemanfaatan tanaman kelapa (Cocos nucifera L.) di Desa Sungai Sorik dan Rawang Ogung telah dilakukan untuk mengetahui ada beberapa ragam, hubungan kekerabatan dan manfaat tanaman kelapa (Cocos nucifera L.). Eksplorasi tanaman kelapa (Cocos nucifera L.) dilakukan di Desa Sungai Sorik dan Rawang Ogung Struktur Perkembangan Tumbuhan, dilaksanakan Februari-Juli 2021. Metode penelitian digunakan eksplorasi dan pengamatan dan pengukuran bagian tanaman untuk membuat deskripsi kelapa (Cocos nucifera L.). Hasil pengamatan morfologi dan anatomi berupa data kualitatif dan kuantitatif. Hasil penelitian didapatkan tiga ragam tanaman kelapa (Cocos nucifera L.) yaitu kelapo dalam (pelak/polak), kelapo genjah (unggul), kelapo kuning. Semua bagian tanaman kelapa memiliki manfaat ekonomi terutama buah kelapa dalam (pelak) memiliki daging buah paling tebal (1,7 cm) dan kelapo genjah (unggul) memiliki buah paling berat (2,6 kg).
PERAN COP26 SEBAGAI PENDUKUNG PENCAPAIAN TUJUAN 13 SDGS DI INDONESIA, DALAM PANDANGAN GREENPEANCE
Authors: Perbina Novika , Jeremie S Billy , FM Pasaribu Rueben 
Published: May 2022

Lately, the issue of climate change is being discussed. Whether it's in social media or mass media. Not without reason, the issue of climate change is discussed, this is because there is not a single human being who is not affected by climate change. Starting from temperature changes, droughts, extreme weather, sea-level rise, and so on. Various ways have been taken to deal with this issue and one of them is the United Nations Conference on climate change (COP26). In this meeting, various agreements have been agreed such as measures to reduce the use of coal-fired electricity and others. This paper will discuss the relevance of COP26 to achieving the objectives of SDGs 13 in Indonesia.

Belakangan ini, isu perubahan iklim sedang gencar diperbincangkan. Entah itu dalam media sosial maupun media massa. Bukan tanpa alasan isu perubahan iklim ini diperbincangkan, hal ini dikarenakan tidak ada satu manusia yang tidak terkena dampak dari perubahan iklim. Mulai dari perubahan suhu, kekeringan, cuaca ekstrim, kenaikan permukaan air laut dan lain sebagainya. Berbagai cara telah dilakukan untuk menangani isu ini dan salah satunya adalah Konferensi PBB yang membahas tentang perubahan iklim (COP26). Dalam pertemuan ini, berbagai kesepakatan telah disepakati seperti langkah untuk mengurangi penggunaan listrik berbahan bakar batu bara dan lainnya. Tulisan ini akan membahas relevansi COP26 untuk tercapainya tujuan SDGS 13 di Indonesia.
PENGARUH PENAMBAHAN DAUN PANDAN WANGI PADA PENGOLAHAN VCO (VIRGIN COCONUT OIL) TERHADAP KESUKAAN KONSUMEN
Authors: Prianto Jeki , Novitasari Rifni , Apriyanto Mulono 
Published: May 2022

This study aims to determine the effect of adding fragrant pandan leaves on VCO (Virgin Coconut Oil) processing on consumer preferences. This study used a completely randomized design method (CRD) with one factor, namely the concentration of addition of fragrant pandan leaf extract (P): (0%, 0.05%, 0.10%). Parameter analysis is the organoleptic test (color, taste, aroma, viscosity). The results showed that the concentration of addition of different fragrant pandan leaf extracts gave significantly different effects on the organoleptic test (color, taste, aroma, and viscosity). The results showed that the highest consumer preference assessment in the organoleptic test was found in the P2 treatment with a concentration of 0.20% addition of fragrant pandan leaf extract resulting in VCO which was liked by the community and was acceptable.

Abstrak
Penelitian ini bertujuan untuk mengetahui pengaruh penambahan daun pandan wangi pada pengolahan VCO (Virgin Coconut Oil) terhadap kesukaan konsumen. Penelitian ini menggunakan metode rancangan Acak Lengkap (RAL) dengan satu faktor yakni konsentrasi penambahan ekstrak daun pandan wangi (P) : (0%, 0,05%, 0,10%). Parameter analisa adalah uji organoleptik (warna, rasa, aroma, kenentalan). Hasil penelitian menunjukkan bahwa konsentrasi penambahan ekstrak daun pandan wangi yang berbeda memberikan pengaruh yang berbeda nyata terhadap uji organoleptik (warna, rasa, aroma, dan kekentalan). Hasil penelitian menunjukkan bahwa penilaian kesukaan konsumen tertinggi pada uji organoleptik terdapat pada perlakuan P2 dengan konsentrasi penambahan ekstrak daun pandan wangi 0,20% menghasilkan VCO yang di sukai masyarakat dan dapat diterima.
Predicting the 2022 Australian Federal Election with Actuarial Methodologies
Authors: Kundu Sumedh , Madgwick Stuart 
Published: May 2022

Election forecasting has, for a long time, been considered a major tool used by voters and politicians alike to understand the electoral mood. In Australia, tools such as opinion polling even drive many policy decisions made by governments. Yet, these same tools have been misleading and/or wrong in recent elections. The consequences of this have meant large fiscal loss for bookmakers, rash policy decisions, inappropriate leadership changes, and, recently, erosion of trust in the democratic process. Hence, we must look at new ways to analyse elections, and use a more appropriate system to mimic the actual voting system in the country where the election is being held. For example, in representative democracies with strong minor party representation like Australia, any forecasting method used must not use two-party preferred on a national basis, and, instead, analyse preference flows, and first preferences, for each seat. This study uses actuarial techniques to analyse probabilities of parties winning each of the 151 seats in the 2022 Election, and then calculates final party totals based on these probabilities.

This study aims to accurately predict the 2022 Election using a methodology which will enable a final forecast which is not misleading and is, in fact, appropriate for a representative democracy. Data used includes first preferences and Preference Flow data from the 2019 Election, Demographic data from the 2016 Census, Economic Data across 2019-22, and Opinion Polls from The Australian and Roy Morgan. Further, political insight will be used to discuss these results and the potential variances.
INFRARED SPECTRA OF THE FREE BASE OF PHTHALOCYANINE AND ITS DEUTERATED DERIVATIVES AND THEIR INTERPRETATION
Authors: Gladkov L. L. , Sokolov N. A. , Solovyov K. N. 
Published: May 2022

The IR spectra of the free base of phthalocyanine and three of its deuterium derivatives have been studied experimentally and theoretically. Calculations of normal vibrations by the density functional theory method made it possible to carry out a detailed interpretation of the spectra and their changes upon isotope
substitution. Vibrations, frequencies of which are sensitive to the isotopic substitution of various positions of the molecule, have been established. A high delocalization of plane bending vibrations of NH bonds has been noted with the greatest change in vibration frequencies not exceeding 85 cm–1.
STRUCTURAL AND OPTICAL PROPERTIES OF SiC/Si HETEROSTRUCTURES OBTAINED USING RAPID VACCUM-THERMAL CARBIDIZATION OF SILICON
Authors: Lobanok M. V. , Mukhammad A. I. , Gaiduk P. I. 
Published: May 2022

TEM investigation revealed that the rapid vacuum-thermal carbidization of silicon at 1100C leads to the formation of cubic silicon carbide (SiC) layers. The band of the IR transmission spectrum at 798 cm–1 corresponding to the stretching vibration of Si-C and the maximum of Raman spectrum at 793 cm–1 relating to transverse optical phonon mode of SiC confirm the formation of a layer of the cubic SiC politype. The absorption
band of Si-O-Si (1100 cm–1) was found using the IR-spectroscopy. The dependence of the transmission coefficient on the wavenumber was determined.
DETECTION AND CLASSIFICATION OF VEHICLES IN ULTRA-HIGH RESOLUTIONS IMAGES USING NEURAL NETWORKS
Authors: Chen Ch. , Мinald А. А. , Bohush R. P. , Ma G. , Weichen Y. , Аblameyko S. V. 
Published: May 2022

The paper proposes a deep neural network architecture based on the integration of the convolutional neural network Faster R-CNN with the Feature Pyramid Network module. Based on this approach, an algorithm for detecting and classifying vehicles in images and a corresponding model have been developed.
A cross-platform environment ML.NET was used to train the proposed model. The results of comparing the effectiveness of the proposed approach and convolutional neural networks YOLO v4 and Faster R-CNN are presented. The improvement of the accuracy of detection and localization of different types of vehicles in ultra-high resolutions images is shown. Examples of processing ultra-high resolutions remote sensing images and appropriate recommendations are given.