bluuebunny/crossref_metadata_2025_split huggingface dataset:
SOCS2 regulation of growth hormone signaling requires a canonical interaction with phosphotyrosine
Authors: Li Kunlun , Meza Guzman Lizeth G. , Whitehead Lachlan , Leong Evelyn , Kueh Andrew , Alexander Warren S. , Kershaw Nadia J. , Babon Jeffrey J. , Doggett Karen , Nicholson Sandra E. 
Published: November 2022

Abstract
Suppressor of cytokine signaling (SOCS) 2 is the critical negative regulator of growth hormone (GH) and prolactin signaling. Mice lacking SOCS2 display gigantism with increased body weight and length, and an enhanced response to GH treatment. Here, we characterized mice carrying a germ-line R96C mutation within the SOCS2-SH2 domain, which disrupts the ability of SOCS2 to interact with tyrosine-phosphorylated targets. Socs2R96C/R96C mice displayed a similar increase in growth as previously observed in SOCS2 null (Socs2−/−) mice, with a proportional increase in body and organ weight, and bone length. Embryonic fibroblasts isolated from Socs2R96C/R96C and Socs2−/− mice also showed a comparable increase in phosphorylation of STAT5 following GH stimulation, indicating the critical role of phosphotyrosine binding in SOCS2 function.
i(cm)z, a semi-analytic model for the thermodynamic properties in galaxy clusters: Calibrations with mass and redshift, and implication for the hydrostatic bias
Authors: Ettori S. , Lovisari L. , Eckert D. 
Published: November 2022

Context. In the self-similar scenario for galaxy cluster formation and evolution, the thermodynamic properties of the X-ray emitting plasma can be predicted in their dependencies on the halo mass and redshift only. However, several departures from this simple self-similar scenario have been observed.
Aims. We show how our semi-analytic model i(cm)z, which modifies the self-similar predictions through two temperature-dependent quantities, the gas mass fraction fg = f0Tf1Ezfz and the temperature variation fT = t0Tt1Eztz, can be calibrated to incorporate the mass and redshift dependencies.
Methods. We used a published set of 17 scaling relations to constrain the parameters of the model. We were subsequently able to make predictions as to the slope of any observed scaling relation within a few percent of the central value and about one σ of the nominal error. Contextually, the evolution of these scaling laws was also determined, with predictions within 1.5σ and within 10 percent of the observational constraints. Relying on this calibration, we have also evaluated the consistency of the predictions on the radial profiles with some observational datasets. For a sample of high-quality data (X-COP), we were able to constrain a further parameter of the model, the hydrostatic bias b.
Results. By calibrating the model versus a large set of X-ray scaling laws, we have determined that (i) the slopes of the temperature dependence are f1 = 0.403 (±0.009) and t1 = 0.144 (±0.017); and that (ii) the dependence upon Ez are constrained to be fz = −0.004 (±0.023) and tz = 0.349 (±0.059). These values, which are inserted in the scaling laws that propagate the mass and redshift dependence to the integrated quantities, permit one to estimate directly how the normalizations of a given quantity QΔ changes as a function of the mass (or temperature) and redshift halo in the form QΔ ∼ MaMEzaz ∼ TaT EzaTz, which is in very good agreement with the current observational constraints. When applied to the best spatially resolved data, we obtained estimates of the hydrostatic bias b that are lower than, but still comparable with, the results obtained by other, more standard, means. We conclude that the calibrated semi-analytic model i(cm)z is able to make valuable predictions on the slope and redshift evolution of the X-ray scaling laws, and on the expected radial behavior of the thermodynamic quantities, including any possible hydrostatic bias.
AMBAND Bone-Conduction Headband
Authors: Margolis Robert H. , Margolis Janet C. 
Published: November 2022

Abstract
Purpose As bone-conduction thresholds vary with the coupling force between the vibrator and the head, it is important that the coupling force be within the range specified by audiometer standards. The development and validation of AMBAND, an elastic headband for coupling an audiometric bone vibrator to the head, in either the mastoid or forehead position, is described.
Methods The headband was constructed from woven, fold-over elastic with Velcro attachment points to produce the proper force on the head for various head sizes. Force measurements were made with a digital force gauge on five artificial heads, representing adult females, adult males, children (age 6 years), infants (age 6 months), and newborns with the bone vibrator in the mastoid and forehead positions. Additional measurements were made with the Radioear P-3333 spring band that is in common use.
Results Force measurements were highly repeatable within a given headband and across headbands. Force measurements for AMBAND were within the range specified by the ANSI S3.6-2018. The Radioear P-3333 spring band produced force levels that exceeded the specified range and had higher variability compared with AMBAND.
Conclusion AMBAND can be used to couple audiometric bone vibrators to the head in the forehead and mastoid positions during bone-conduction testing to provide accurate threshold measurements.
The Role of Presepsin as a Biomarker of Sepsis in Children: A Systemic Review and Meta-Analysis
Authors: Khera Daisy , Toteja Nisha , Singh Simranjeet , Didel Siyaram , Singh Kuldeep , Chugh Ankita , Singh Surjit 
Published: November 2022

Abstract
Objectives Biomarkers in sepsis are an arena of avid research as they can facilitate timely diagnosis and help reduce mortality. Presepsin is a promising candidate with good diagnostic performance reported in adult and neonatal studies. However, there is no clear consensus about its utility in the pediatric age group. This study aimed to synthesize scientific evidence regarding the diagnostic and prognostic performance of presepsin in pediatric sepsis.
Data Sources A systematic literature search was conducted in MEDLINE/PubMed, Cochrane Central Register of Clinical Trials, Google Scholar, and Scopus to identify relevant studies reporting the diagnostic and prognostic accuracy of presepsin.
Study Selection Using Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, we retrieved all controlled trials and observational studies on presepsin as a biomarker in children aged <19 years with sepsis.
Data Extraction Two authors independently performed study screening, data extraction, and quality assessment of the included studies.
Data Synthesis Among the 267 citations identified, a total of nine relevant studies were included in the final analysis. The pooled diagnostic sensitivity and specificity of presepsin were 0.99 (95% confidence interval [CI]; 0.97–1.00) and 0.88 (95% CI; 0.83–0.92), respectively, with a diagnostic odds ratio (DOR) of 28.15 (95% CI; 0.74–1065.67) and area under the curve (AUC) in summary receiver operating curve of 0.89. Prognostic accuracy for presepsin had a sensitivity of 0.64 (95% CI; 0.35–1.0), specificity of 0.62 (95% CI; 0.44–0.87), and DOR of 3.3 (95% CI; 0.20–53.43). For procalcitonin, the pooled sensitivity for diagnostic accuracy was 0.97 (95% CI; 0.94–1.00), specificity was 0.76 (95% CI; 0.69–0.82), DOR was 10.53 (95% CI; 5.31–20.88), and AUC was 0.81.
Conclusion Presepsin has good diagnostic accuracy with high sensitivity and specificity. Its prognostic accuracy in predicting mortality is low.
Shining a light on an additional clinical burden: work-related digital communication survey study – COVID-19 impact on NHS staff wellbeing
Authors: Bakhai Ameet , McCauley Leah , Stones Liba , Khalil Saria , Mehta Jay , Price Nicola , Krishnamurthy Vinodh , Parker Lucy H. H. , Hughes Derralynn 
Published: November 2022

AbstractWork-related communication volume within the United Kingdom’s National Health Service (NHS) has had little systematic research previously. The impact of communication volume on work-life balance of healthcare staff in the NHS is also not known and has not been an area of focus or governance. COVID-19 led to a shift to non-physical work, with greater reliance on digital communication for clinical decision making. We sought to elucidate the relationship between communication, work-life balance, and COVID-19. An online survey was conducted to assess the platforms used to communicate professionally, the volume of and time spent on work-related communications, how this has changed from before to during COVID-19, and the effect on work-life balance. A total of 3047 healthcare staff provided consent and evaluable data. Emails were reported as the most frequently used communication tool, and the majority of staff asked, reported increased work-related communications due to COVID-19. Staff estimated receiving 14 emails on an average day before COVID-19. During the pandemic, staff estimated getting approximately 17 emails on an average day and 29 emails on a busy day. Work communications reportedly took up increased amounts of family and home time during COVID-19. A large proportion (36%) of staff were unable to switch off from work-related communications already before COVID-19, worsening (57%) during the pandemic. Work-related digital communication is a vital component of working in the NHS. We provide the first detailed data on the types, volume, and impact of such communication on NHS staff during the COVID-19 pandemic, compared to pre-pandemic levels. We found that 82% of staff support the need for NHS guidance on work-related communications to help manage overload, protect emotional wellbeing, and increase resilience. Further work is urgently needed in this area to tackle the negative impact of communication technologies (technostress) on work-life balance to reduce staff stress, burnout, and turnover or early retirement of some staff.
Similar grazing mechanisms explain contrasting intake and sward-height dynamics under different grazing management
Authors: Pontes-Prates Arthur , Carvalho Paulo César de Faccio , Bolzan Anderson Michel Soares , Savian Jean Víctor , Félix da Silva Neto Gentil , Sánchez Zubieta Ángel , Laca Emilio Andrés 
Published: November 2022

Context Average sward height has traditionally been used as a grazing management variable. However, such approach ignores the spatio-temporal heterogeneity of swards. Because the intake rate responds non-linearly to average height at plant level, we expected that sheep exposed to contrasting grazing methods with similar average heights would behave differently. Aims We hypothesised that low-intensity, high-frequency grazing results in a higher daily intake rate than does high-intensity, low-frequency grazing, despite both methods having similar average sward heights over space and time. Also, we asked whether sheep exhibit the same foraging mechanisms for a given instantaneous sward state regardless of long-term grazing conditions imposed. Methods We exposed sheep to two contrasting grazing methods with similar average height; low-intensity, high-frequency (LIHF), and high-intensity, low-frequency (HILF). We then evaluated their foraging behaviour using continuous bite-monitoring paired with detailed sward measurements during grazing down. Key results Sward height decreased markedly during the grazing period in both treatments, but the sward height depletion was faster under HILF (7.5 cm and 20.3 cm for LIHF and HILF), which means that sward structure was severely disrupted. The animals exhibited markedly different herbage intake patterns between the grazing methods, with sheep under LIHF presenting greater total daily herbage intake (850 vs 630 g DM per individual). Also, sheep demonstrated a more stable and higher instantaneous intake rate in the LIHF. Despite the difference in total daily herbage intake, the grazing treatments did not affect the behavioural mechanisms beyond their indirect effects on the rate of change in the instantaneous sward conditions. Grazing treatments created different patterns of sward change and intake rate over time, but the local and instantaneous sward conditions determined intake rate regardless of the grazing method. Conclusions Intake responses of sheep differed between grazing methods with similar average height due to sward heterogeneity over time and space. Grazing mechanisms were not directly affected by the treatments but were influenced by the sward heterogeneity imposed by the grazing management. Implications Grazing management requires not only consideration of the average sward height, but also an understanding of how the resource is distributed in time and space.
A vertical inertial sensor with interferometric readout
Authors: Kranzhoff S L , Lehmann J , Kirchhoff R , Carlassara M , Cooper S J , Koch P , Leavey S , Lück H , Mow-Lowry C M , Wöhler J , von Wrangel J , Wu D S 
Published: November 2022

Abstract
High precision interferometers such as gravitational-wave detectors require complex seismic isolation systems in order to decouple the experiment from unwanted ground motion. Improved inertial sensors for active isolation potentially enhance the sensitivity of existing and future gravitational-wave detectors, especially below 30 Hz, and thereby increase the range of detectable astrophysical signals. This paper presents a vertical inertial sensor which senses the relative motion between an inertial test mass suspended by a blade spring and a seismically isolated platform. An interferometric readout was used which introduces low sensing noise, and preserves a large dynamic range due to fringe-counting. The expected sensitivity is comparable to other state-of-the-art interferometric inertial sensors and reaches values of

10

−
10

m

(

H
z

1

/

2

)

−
1

at 100 mHz and

10

−
12

m

(

H
z

1

/

2

)

−
1

at 1 Hz. The potential sensitivity improvement compared to commercial L-4C geophones is shown to be about two orders of magnitude at 10 mHz and 100 mHz and one order of magnitude at 1 Hz. The noise performance is expected to be limited by thermal noise of the inertial test mass suspension below 10 Hz. Further performance limitations of the sensor, such as tilt-to-vertical coupling from a non-perfect levelling of the test mass and nonlinearities in the interferometric readout, are also quantified and discussed.
An electromagnetically actuated ball and socket joint for applications in 3D metrology
Authors: Narendra M , Arya B N , Jayanth G R 
Published: November 2022

Abstract
The design, development and application of a novel magnetically actuated ball-and-socket joint has been presented here. The joint comprises a current-carrying conductor acting as the socket and a permanent magnet ball. External solenoid coils are employed to orient the ball in any desired direction. A novel strategy, based on providing a small vibratory input, is proposed to eliminate static friction. The joint has been fabricated and experimentally demonstrated to rotate over a large range of about ±

70
∘

with a low cross-axis rotation, of about 8%, and with negligible hysteresis. The developed joint has been employed as a touch-trigger probe in a coordinate measurement machine to access all the three surfaces in a cuboidal corner of a sample.
Teaching planetary retrograde motion using a local positioning system
Authors: Lee Kaela J , DeStefano Paul R , Shaaban Lori , Dunlap Justin C , Widenhorn Ralf 
Published: November 2022

Abstract
For millennia, humans have observed planetary retrograde motion and attempted to explain the phenomena. Our modern understanding of the motions of bodies within the Solar System is built up from a rich history of past models, each of which tried to explain astronomical observations while also being influenced by the contemporary belief system. One of the pivotal observations that assisted astronomers in the development of our current planetary model is planetary retrograde motion. Complexities in heliocentric and geocentric planetary models coupled with the change of reference frame required to visualize retrograde can be challenging for students. For this reason, we developed a kinaesthetic learning activity for introductory physics and astronomy courses that requires students to physically walk planetary orbits and allows them to see apparent motions across a virtual sky in real-time. In this paper, we present multiple activities using a local positioning system that are based on changing historical models for the retrograde phenomenon. We aim for these activities to culminate in students’ holistic understanding of how astronomically observed retrograde patterns were explained by models stemming from the existing scientific knowledge and beliefs available at the time.
Jacobi partial waves for a set of 3D noncentral rational scatterers
Authors: Maulion Marvin A , Carpio-Bernido M Victoria , Bernido Christopher C 
Published: November 2022

Abstract
The common tool of choice for basis expansions for the scattering problem with 3D quantum systems remains the spherical harmonics as eigenfunctions of the Laplace–Beltrami operator on the sphere, with approximations for deviations made around the usually dominant s-wave spherically symmetric state. However, with the growing number of technologically accessible nonspherically symmetric geometries of cold atomic and molecular systems, there is a need to explore as orthonormal bases for partial wave analysis the larger class of weighted Jacobi polynomials, subsuming the spherical harmonics. In particular, the lowest angular state for this bigger class is a toroid instead of a spherical s-orbital. This allows analytic treatment of a wider array of rational angular-dependent potentials which can describe rings and systems with topological constraints such as monopoles. Here, we present exact analytic solutions for the quantum scattering problem by partial wave analysis using the weighted Jacobi polynomials as an expanded basis. We obtain the scattering amplitude, differential and total cross-sections for exactly solvable 3D potentials included in the Smorodinsky-Winternitz noncentral systems with dynamical symmetries. Moreover, this procedure also solves the quantum scattering problem from a novel series of rational trigonometric forms of anisotropic potentials including double ring-shaped configurations.
Possible origin of extremely large magnetoresistance in the topological insulator CaBi2 single crystal
Authors: Ma Yuzhe , Wang Yulong , Wang Gang 
Published: November 2022

Abstract
CaBi2 has been experimentally found to be a superconductor with a transition temperature of 2 K and identified as a topological insulator via spin- and angle-resolved photoemission spectroscopy, which makes it a possible platform to study the interplay between superconductivity and topology. But the detailed transport properties for CaBi2 single crystal remain unexplored in experiments. Here, we systematically studied the magneto-transport properties of CaBi2 single crystal grown by a flux method. CaBi2 shows a magnetic-field-induced upturn behavior with a plateau in resistivity at low temperature. An extremely large and non-saturating magnetoresistance up to ∼15000% at 3 K and 12 T was achieved. The possible reason for the magnetic field and temperature dependence of resistivity and extremely large magnetoresistance at low temperature was discussed by adopting the Kohler’s scaling law, which can be understood by the compensation effect confirmed by the Hall Effect measurement.
Complex dynamics in a novel jerk system with septic nonlinearity: analysis, control, and circuit realization
Authors: Ramadoss Janarthanan , Kengnou Telem Adelaïde Nicole , Kengne Jacques , Rajagopal Karthikeyan 
Published: November 2022

Abstract
This work proposes a new chaotic jerk system with septic nonlinearity. The new system presents odd symmetry and undergoes typical behaviors including period doubling, merging crisis, spontaneous symmetry breaking, coexisting attractors and coexisting bubbles of bifurcations as well. The most gratifying feature discovered in this article, is the occurrence of up to eight coexisting attractors for appropriate sets of parameters. This latter feature is uncommon for a chaotic system as simple as the model proposed in this work (e.g. not reported in cubic, quintic or hyperbolic sine models). Multistability control is achieved by following the linear augmentation approach. We numerically prove that the multistable septic chaotic system can be adjusted to develop a monostable behavior when smoothly monitoring the coupling strength. More interestingly, it is found that the coupling breaks the symmetry of the chaotic jerk system and thus induces new patterns including asymmetric Hopf bifurcations; coexisting non-symmetric bubbles, critical phenomena, coexisting multiple asymmetric attractors, just to name a few. On this line, the linear augmentation scheme can be regarded as a simple means for inducing new features in odd symmetric chaotic systems. PSPICE simulation results captured from an electronic analog of the proposed septic jerk system are consistent with the theoretical investigations.
The Canfranc Axion Detection Experiment (CADEx): search for axions at 90 GHz with Kinetic Inductance Detectors
Authors: Aja Beatriz , Arguedas Cuendis Sergio , Arregui Ivan , Artal Eduardo , Barreiro R. Belén , Casas Francisco J. , de Ory Marina C. , Díaz-Morcillo Alejandro , de la Fuente Luisa , Gallego Juan Daniel , García-Barceló Jose María , Gimeno Benito , Gomez Alicia , Granados Daniel , Kavanagh Bradley J. , Laso Miguel A.G. , Lopetegi Txema , Lozano-Guerrero Antonio José , Magaz Maria T. , Martín-Pintado Jesús , Martínez-González Enrique , Miralda-Escudé Jordi , Monzó-Cabrera Juan , Najarro de la Parra Francisco , Navarro-Madrid Jose R. , Nuñez Chico Ana B. , Pascual Juan Pablo , Pelegrin Jorge , Peña Garay Carlos , Rodriguez David , Socuéllamos Juan M. , Teberio Fernando , Teniente Jorge , Vielva Patricio , Vila Iván , Vilar Rocío , Villa Enrique 
Published: November 2022

AbstractWe propose a novel experiment, the Canfranc Axion Detection Experiment (CADEx), to probe dark matter axions with masses in the range 330–460μeV, within the W-band (80–110 GHz), an unexplored parameter space in the well-motivated dark matter window of Quantum ChromoDynamics (QCD) axions. The experimental design consists of a microwave resonant cavity haloscope in a high static magnetic field coupled to a highly sensitive detecting system based on Kinetic Inductance Detectors via optimized quasi-optics (horns and mirrors). The experiment is in preparation and will be installed in the dilution refrigerator of the Canfranc Underground Laboratory. Sensitivity forecasts for axion detection with CADEx, together with the potential of the experiment to search for dark photons, are presented.
Primordial black holes induced stochastic axion-photon oscillations in primordial magnetic field
Authors: Li Hai-Jun 
Published: November 2022

Abstract
Primordial black holes (PBHs) can be produced in the very early Universe due to the large
density fluctuations. The cosmic background of axion-like particles (ALPs) could be non-thermally
generated by PBHs. In this paper, we investigate the ALPs emitted by ultra-light PBHs with the
mass range 10g ≲ M
PBH ≲ 109 g, in which PBHs would have
completely evaporated before the start of Big Bang Nucleosynthesis (BBN) and can therefore not be
directly constrained. In this case, the minimal scenario that ALPs could interact only with
photons is supposed. We study the stochastic oscillations between the ALPs and photons in the
cosmic magnetic field in detail. The primordial magnetic field (PMF) can be modelled as the
stochastic background field model with the completely non-homogeneous component of the cosmic
plasma. Using the latest stringent limits on PMF, we show the numerical results of ALP-photon
oscillation probability distributions with the homogeneous and stochastic magnetic field
scenarios. The PBH-induced stochastic ALP-photon oscillations in the PMF may have the effects on
some further phenomena, such as the cosmic microwave background (CMB), the cosmic X-ray background
(CXB), and the extragalactic gamma-ray background (EGB).