bluuebunny/crossref_metadata_2025_split huggingface dataset:
Petrochemistry and mineralogy of pumice from the Sarychev Peak Volcano, Matua Island, Central Kuril Island
Authors: Okrugin V. M. , Skilskaia E. D. , Moskaleva S. V. 
Published: October 2022

Background. The article presents the first results of a mineralogical and petrographic study of the pumice of the Sarychev Peak volcano, Matua island, the Central Kuril islands.Aim. To reconstruct the compositions of magmatic melts of a caldera-forming eruption of the proto-Matua volcano.Materials and methods. The main research methods included an X-ray fluorescence spectral analysis to determine the content of petrogenic, rare and trace elements, as well as an electron-probe microanalysis to study variations in the chemical composition of mineral inclusions of pumice.Results and conclusion. According to the content of SiO2 and the sum of alkalis, the composition of pumice varies from andesibasaltes (SiO2 = 55.94 wt.%) to dacites (SiO2 = 67.70 wt.%). According to the content of K2O, pumice can be classified as a moderate-potassium series of rocks. The inclusion minerals represented by plagioclase, amphibole, apatite and Fe-Ti oxides were crystallized at the same time from a water-saturated magmatic melt at a pressure of about 1.5–2.2 kbar. The igneous melt was enriched with volatile components of H2O, CO2, S, F and Cl.
Laser activatable perfluorocarbon bubbles for imaging and therapy through enhanced absorption from coupled silica coated gold nanoparticles
Authors: Fernandes Donald A. , Appak-Baskoy Sila , Berndl Elizabeth , Kolios Michael 
Published: October 2022

<p>Nanoparticles have extensively been used for cancer therapy and imaging (<em>i.e.</em>, theranostics) using various imaging modalities. Due to their physical and chemical properties (<em>e.g.</em>, absorption, fluorescence, and magnetic properties) they have been used for image guided therapy for cancer treatment monitoring. There are various limitations that make many theranostic agents unable to be used for the extended periods of time required for enhancing theranostic capabilities. Some of these are due to inherent characteristics (<em>e.g.</em>, change and/or breakdown of structure) present upon continuous irradiation and others are due to environmental (<em>i.e.</em>, physiological) conditions that can lead to physical instability (<em>i.e.</em>, in terms of size) affecting the amount of particles that can accumulate at the target site and the overall contrast that can be achieved. In this study, perfluorohexane (PFH) nanoemulsions (NEs) were synthesized with silica coated gold nanoparticles (PFH-NEs-scAuNPs) in order to give both stable and enhanced signals for cancer imaging by increasing vaporization of the emulsions into bubbles through the process of optical droplet vaporization (ODV). The resulting perfluorohexane bubbles could be imaged using nonlinear ultrasound (NL US) which significantly increases the signal to noise ratio due to the nonlinear scattering properties of oscillating bubbles. The NL US signals from PFH bubbles were found to be more stable compared to conventional bubbles used for contrast imaging. In addition, the vaporization of PFH NEs into bubbles was shown to cause significant cancer cell death reflecting the theranostic capabilities of the formed PFH bubbles. Since cell death is initiated with laser excitation of PFH-NEs-scAuNPs, these nanoparticles can specifically target cancer cells once they have accumulated at the tumor region. Due to the type of theranostic agent and imaging modality used, the PFH-NEs-scAuNPs can be used to provide higher specificity compared to other agents for locating the tumor region by minimizing tissue specific signals while at the same time being used to treat cancer. </p>
La informalidad del comercio en México; retos para la 4T, respecto de la evasión fiscal
Authors: Chávez Chávez José Luis , Medina Cano Daniel 
Published: October 2022

Las fugas fiscales en nuestro país son tan antiguas como la misma tributación, y al pasar de los años los impuestos y las prácticas de evasión fiscales se han modificado; en la actualidad el comercio informal ocupa el primer sitio entre la falta de pago de impuestos para nuestro país, ya que el desempleo en ascenso y la falta de inversión en el país arrastran a los mexicanos a ésta actividad que representa un verdadero paraíso fiscal, puesto que no son reguladas sus actividades comerciales y las realizan en lugares públicos.
Actualmente podremos ver las plazas comerciales funcionando como tianguis y ferias, cuando éstas deberían de cumplir su función sustantiva para lo que fueron creadas; y que decir de los ciudadanos, podríamos comprometernos hacer frente a nuestras obligaciones fiscales de conformidad con las leyes, tributando de manera establecida ordenada y organizada, lo que propiciaría un mejor nivel de vida, gracias a que todos tomemos la responsabilidad de darle al estado lo que le corresponde.
De igual manera el estado debe buscar la manera de ayudar a los inversionistas, respecto de que los impuestos dejen de ser una carga financiera primordial, buscando que estos sean menos agresivos y como consecuencia impulsar una mejor fiscalización, que haga que todos los mexicanos contribuyamos de manera proporcional y equitativa para el gasto publico.
Linguistic Theory intafsīrbetween 100/400 and 700/1000: Implications for Qur’anic Studies
Authors: Mårtensson Ulrika 
Published: October 2022

The article aims to explore the possibility that tafsīr and the Qur’an might share a common linguistic theory, and the methodological relevance of such a relationship for Qur’anic studies. This is done by, firstly, engaging with debates on the definitions and dating of tafsīr and the methodological implications of these; secondly, by developing a model of a theoretical paradigm that spans the disciplines of tafsīr, linguistics, rhetoric, and law, and applying it to the interpretations of key terms in five Qur’anic verses as found in the works of a selection of exegetes. The exegetes in question are Muqātil b. Sulaymān (d. 150/767), ʿAbd al-Razzāq al-Ṣanʿānī (d. 211/827), Yaḥyā b. Sallām (d. 200/815), Ibn Abī Zamanīn (d. 399/1009), and al-Ṭabarī (d. 310/923). The case studies are Q. 1:5–7 ( mustaqīm); Q. 2:1 ( aliflāmmīm dhālika’l- kitāb); Q. 2:125 ( maqām Ibrāhīm); Q. 19:34 ( qawl al-ḥaqq); and Q. 18:19 ( azkā ṭaʿāman).The analysis finds that (1) tafsīr shares a pragmatist semantic paradigm with linguistics and law, and the selected exegetes’ legal methodologies are decisive in shaping their exegetical methods; (2) studies of developments within tafsīr need to consider its relationship with the other disciplines and the diverse exegetical genres; and (3) the pragmatist semantic paradigm connects tafsīr methodology with the Qur’an’s composition and some of its concepts, because they reflect the same theory that meaning depends on context. Consequently, if tafsīr is studied from a discipline- and theory-oriented perspective, it can provide new methodologies for Qur’anic studies.
One-stage hybrid coronary revascularization for the treatment of multivessel coronary artery disease— Periprocedural and long-term results from the “HYBRID-COR” feasibility study
Authors: Sanetra Krzysztof , Buszman Piotr Paweł , Jankowska-Sanetra Justyna , Cisowski Marek , Fil Wojciech , Gorycki Bogdan , Bochenek Andrzej , Slabon-Turska Monika , Konopko Marta , Kaźmierczak Paweł , Gerber Witold , Milewski Krzysztof , Buszman Paweł Eugeniusz 
Published: October 2022

BackgroundThe constant growth of interest in hybrid coronary artery revascularization (HCR) is apparent. Yet, few studies report outcomes of the one-stage HCR. Consequently, the status of such procedures is not adequately supported in clinical guidelines. The aim of this study was to report the safety, feasibility, and long term-outcomes of the one-stage HCR.Methods and resultsPatients were enrolled in the prospective one-stage hybrid coronary revascularization program (HYBRID-COR). They underwent a one-stage hybrid revascularization procedure while on double antiplatelet therapy (DAPT) with Ticagrelor: endoscopic atraumatic coronary artery bypass grafting (EACAB) for revascularization of the left anterior descending (LAD) artery and percutaneous intervention in non-LAD arteries with contemporary drug-eluting stents. The composite primary endpoint included MACCE (major adverse cardiac and cerebrovascular events: death, myocardial infarction, stroke, and repeated revascularization) in long-term observation. The study cohort consisted of 30 patients (68% male) with stable coronary artery disease (26.7%) and unstable angina (73.3%). Procedural success was 100%. No death, myocardial infarction (MI), or stroke were observed in the perioperative period. One patient (3.3%) required chest revision and blood transfusion due to surgical bleeding. Kidney injury was noted in two patients (6.6%). In a long-term follow-up (median; IQR: 4.25; 2.62–4.69 years), two patients (6.6%) underwent repeated revascularization and one patient (3.3%) died due to MI. The overall primary endpoint rate was 9.9%.ConclusionOne-stage hybrid revascularization, on DAPT, is a feasible, safe, and efficient way of achieving complete revascularization in selected patients. The complication rate is low and acceptable. Further randomized trials are required.
Validation of plasma D-dimer in Chinese patients with acute non-ST segment elevation myocardial infarction
Authors: Fan Xin , Min Tingting , Su Shaohui , Xiong Bin , Wan Huaibin 
Published: October 2022

ObjectiveTo analyze the predictive values of D-dimer in Chinese patients with non-ST-segment elevation myocardial infarction (NSTEMI).MethodsWe retrospectively retrieved consecutive patients hospitalized due to acute NSTEMI from January 2015 to December 2018 from the Electronic Medical Record (EMR) library. Clinical and follow-up data were collected. The primary endpoint was major adverse composite cardiovascular events (MACEs), such as all-cause death, non-fatal myocardial infarction, and non-fatal stroke. The secondary endpoints included all-cause death, non-fatal myocardial infarction, non-fatal stroke, heart failure, and severe arrhythmias. The Cox regression model was used to evaluate the association between risk factors and clinical outcomes in Chinese patients with NSTEMI.ResultsA total of 673 patients were included; the median age was 64.0 (53.0–75.0) years old and 76.2% were men. Patients with higher D-dimer levels were more often women, older, had a higher Charlson Comorbidity Index, and had a higher incidence of MACEs (59.9 vs. control 9.0%; p &lt; 0.001) and all-cause death (49.1 vs. control 2.2%; p &lt; 0.001). The multivariate Cox analysis suggested that the D-dimer level was an independent predictor of MACEs (hazard ratio [HR]: 1.069, 95% CI: 1.010–1.132, p = 0.021). The receiver operating characteristic (ROC) analysis suggested that D-dimer levels were better than the Charlson Comorbidity Index in all-cause death.ConclusionIn Chinese patients with acute NSTEMI, higher D-dimer levels on admission suggest a poor long-term prognosis.
Percutaneous coronary intervention in patients with cancer using bare metal stents compared to drug-eluting stents
Authors: Ahmed Talha , Pacha Homam Moussa , Addoumieh Antoine , Koutroumpakis Efstratios , Song Juhee , Charitakis Konstantinos , Boudoulas Konstantinos Dean , Cilingiroglu Mehmet , Marmagkiolis Konstantinos , Grines Cindy , Iliescu Cezar A. 
Published: October 2022

BackgroundManagement of coronary artery disease (CAD) is unique and challenging in cancer patients. However, little is known about the outcomes of using BMS or DES in these patients. This study aimed to compare the outcomes of percutaneous coronary intervention (PCI) in cancer patients who were treated with bare metal stents (BMS) vs. drug-eluting stents (DES).MethodsWe identified cancer patients who underwent PCI using BMS or DES between 2013 and 2020. Outcomes of interest were overall survival (OS) and the number of revascularizations. The Kaplan–Meier method was used to estimate the survival probability. Multivariate Cox regression models were utilized to compare OS between BMS and DES.ResultsWe included 346 cancer patients who underwent PCI with a median follow-up of 34.1 months (95% CI, 28.4–38.7). Among these, 42 patients were treated with BMS (12.1%) and 304 with DES (87.9%). Age and gender were similar between the BMS and DES groups (p = 0.09 and 0.93, respectively). DES use was more frequent in the white race, while black patients had more BMS (p = 0.03). The use of DES was more common in patients with NSTEMI (p = 0.03). The median survival was 46 months (95% CI, 34–66). There was no significant difference in the number of revascularizations between the BMS and DES groups (p = 0.43). There was no significant difference in OS between the BMS and DES groups in multivariate analysis (p = 0.26). In addition, independent predictors for worse survival included age &gt; 65 years, BMI ≤ 25 g/m2, hemoglobin level ≤ 12 g/dL, and initial presentation with NSTEMI.ConclusionsIn our study, several revascularizations and survival were similar between cancer patients with CAD treated with BMS and DES. This finding suggests that DES use is not associated with an increased risk for stent thrombosis, and as cancer survival improves, there may be a more significant role for DES.
Association between Rab31/rs9965664 polymorphism and immunoglobulin therapy resistance in patients with Kawasaki disease
Authors: Yu Hongyan , Lin Yueling , Xu Yufen , Chen Kaining , Wang Yishuai , Fu Lanyan , Zhou Huazhong , Pi Lei , Che Di , Qiu Xiantao , Gu Xiaoqiong 
Published: October 2022

BackgroundKawasaki disease (KD) is an acute febrile systemic vasculitis affecting infants and young children. A high dose of intravenous immunoglobulin (IVIG) is the first-line strategy for patients with KD to reduce persistent inflammation and the risk of coronary artery aneurysm (CAA) formation. Unfortunately, 10–20% of the patients showed no response to the treatment and were defined as resistant to IVIG. Rab31 has been reported to regulate innate immunity in several human diseases. However, whether single nucleotide polymorphism (SNP) in Rab31 gene could predispose to IVIG therapy response in KD was uncovered.MethodsRab31/rs9965664 polymorphism was genotyped in 1,024 Chinese patients with KD through TaqMan assay. The odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to assess the strength of association between Rab31/rs9965664 polymorphism and IVIG therapeutic effects.ResultsOur results showed that Rab31/rs9965664 AA/GA genotype was significantly associated with an increased risk of IVIG resistance compared to GG genotype (GA vs. GG: p = 0.0249; AA vs. GG: p = 0.0016; AA/GA vs. GG: p = 0.0039; and AA vs. GG/GA: p = 0.0072). Moreover, the KD individuals carrying the rs9965664 A allele displayed lower Rab31 protein levels, and the expression level of Rab31 in the IVIG-resistant group was decreased significantly when compared to that observed in the response group. A mechanical study demonstrated that Rab31 modulated IVIG response through NLRP3 and p38 pathways.ConclusionThese results suggested that Rab31/rs9965664 polymorphism might be associated with an increased risk of IVIG resistance in southern Chinese patients with KD. The possible mechanism is that Rab31 regulates the NLRP3 pathway negatively to inhibit IVIG response.
Early de-cannulation from extracorporeal membrane oxygenation following ventricular tachycardia radiofrequency ablation
Authors: Sabbag Avi , Nissan Johnatan , Beinart Roy , Sternik Leonid , Kassif Igal , Kogan Alexander , Ram Eilon , Nof Eyal 
Published: October 2022

ObjectivesVentricular tachycardia ablation (VTA) with hemodynamic compromise presents a challenge. Veno-arterial extracorporeal membrane oxygenation (VA-ECMO) support allows the safe completion of the procedure. There are limited data regarding the safety of weaning off VA-ECMO at the end of the procedure. We report our experience with early VA-ECMO de-cannulation after VTA.Materials and methodsAll patients undergoing VA-ECMO-assisted VTA, between January 2013 and December 2020 at a large tertiary center were included. Clinical characteristics, history of arrhythmia, procedural details, and outcomes were collected. Patients weaned from VA-ECMO immediately at the end of the procedure were compared to those that were de-cannulated at a later time.ResultsA total of 46 patients (93.5% male, age 62 ± 10 years) were ablated with VA-ECMO support. Most had ischemic cardiomyopathy (65%) and (70%) presented with VT storm. The clinical VT was induced in the majority of patients (76%). A total of 99 VTs were induced of which 76 (77%) were targeted and successfully ablated. Non-inducibility was achieved in 74% of cases and most patients (83%) were de-cannulated at the end of the procedure on the procedure table. Survival at 1 year was higher among early de-cannulated patients (86 vs. 38% [log-rank p-value &lt; 0.001]). At 1-year follow-up, 91.3% of surviving patients were free of appropriate ICD shocks.ConclusionDe-cannulation from VA-ECMO may be done immediately at the conclusion of VTA in most cases. Failure to timely wean off VA-ECMO is a strong predictor of mortality.
Accelerated catalytic ozonation for aqueous nitrobenzene degradation over Ce-loaded silicas: Active sites and pathways
Authors: Wang Qinghong , Ji Yuanyuan , Hu Jingze , Ye Huangfan , Liu Ya , Wang Yuxian , Chen Chunmao , Li Zhuoyu 
Published: October 2022

Cerium oxides loaded silica catalysts were synthesized by an impregnation method by simply mixing Ce precursor with silica spherule (Ce/SS) and ordered MCM-41 zeolites (Ce/MCM-41), followed by a mild calcination. Compared with pure SS and MCM-41, Ce modified Ce/SS and Ce/MCM-41 demonstrate much improved catalytic ozonation activities for mineralization of recalcitrant nitrobenzene (NB). At solution pH of 6, 86 and 97% TOC mineralization rates were achieved within 60 min for Ce/MCM-41 and Ce/SS, respectively. Characterization results suggest that Ce loading significantly increases the surface Lewis acidic sites, which would synergize with Ce3+/Ce4+ redox cycle for the activity improvement. With the aid of in situ electron paramagnetic resonance (EPR) spectra and quenching tests, hydroxyl radical (·OH), superoxide radical (O2•–), and singlet oxygen (1O2) are identified as the O3 catalytic decomposition products, while ·OH mainly accounts for NB mineralization. The detailed degradation route of NB was further investigated by the multi-chromatography analysis. NB is firstly oxidized into polyhydroxy compounds, followed by small molecular organic acids, and finally being mineralized into CO2 and H2O. This study established a facile strategy to synthesize highly active and stable Ce/SiO2 catalysts for catalytic ozonation, and elucidated the in-depth mechanisms for the activity origins of the Ce loaded silica-based materials in catalytic ozonation processes (COP).
Fasting glucose mediates the influence of genetic variants of SOD2 gene on lean non-alcoholic fatty liver disease
Authors: Wu Na , Zhai Xiangyu , Yuan Fan , Li Jie , Yu Ning , Zhang Fengwei , Li Dong , Wang Jianying , Zhang Lei , Shi Yi , Ji Guang , He Guang , Liu Baocheng 
Published: October 2022

Background: Non-alcoholic fatty liver disease (NAFLD) imposes an enormous burden on public health, and a large proportion of NAFLD patients are lean with normal body weight, which is rarely mentioned. We conducted this study to determine the mediation effects of fasting glucose on the relationships between genetic variants of SOD2 and the susceptibility of lean NAFLD in the elderly Chinese Han population.Methods: Data in this manuscript were collected in a cross-sectional study among 5,387 residents (aged ≥60 years) in the Zhangjiang community center, Shanghai, China, in 2017. Ten (single nucleotide polymorphisms) SNPs previously reported to be related to NAFLD and obesity, including rs9939609, rs1421085, rs9930506, rs626283, rs641738, rs4880, rs58542926, rs738409, rs2281135, and rs2294918 were genotyped. The associations between genetic variations in SOD2 and fasting glucose in five genetic models were analyzed with the SNPassoc R package and rechecked with regression analysis. Mediation models were conducted to explore whether fasting glucose can mediate the association between SNPs and the susceptibility of lean NAFLD.Results: In this study, lean NAFLD individuals had a higher waist circumference and waist-to-hip ratio, ALT, and fasting glucose than lean non-NAFLD individuals (p &lt; 0.050). In comparison, the AA genotypic frequency of rs4880 in SOD2 gene was much lower in lean NAFLD patients (p = 0.005). And rs4800 had a significant indirect effect on lean NAFLD incidence mediated by fasting glucose (p &lt; 0.001).Conclusion: For the first time, the mediation effect of fasting glucose on the association of rs4880 in SOD2 with the susceptibility of lean NAFLD was clarified in the elderly Chinese Han population. It emphasized the connection between glucose homeostasis and oxidative stress in the mechanisms of lean NAFLD.
Feasibility of avian antibodies as prophylaxis against enterotoxigenic escherichia coli colonization
Authors: Brumfield Kyle , Seo Hyesuk , Idegwu Nnebuefe , Artman Chad , Gonyar Laura , Nataro James , Zhang Weiping , Sack David , Geyer James , Goepp Julius 
Published: October 2022

BackgroundThis research aims to evaluate the feasibility of using avian immunoglobulins (IgY) raised against adhesion factors of enterotoxigenic Escherichia coli (ETEC) as prophylaxis of diarrheal illness caused by these pathogens. ETEC requires adhesion to human intestinal epithelial cells as a primary step in establishing enteric infection. Therefore, inhibition of adhesion may prevent such infections and reduce clinical burdens of diarrheal illness.MethodsIgY samples were prepared from eggs of hens immunized with an adhesin-tip multiepitope fusion antigen (MEFA), developed against nine adhesin tip epitopes derived from clinically relevant ETEC strains. The resulting IgY was evaluated for its ability to inhibit adhesion of ETEC to cell-surface targets. Potential impacts of anti-MEFA IgY on growth of both pathogenic and commensal E. coli isolates were also evaluated.ResultsEnzyme linked immunosorbent assay (ELISA) titers were achieved for IgY targeting each of the nine individual epitopes included in the adhesin-tip MEFA. Furthermore, anti-MEFA titers exceeding 1:219 were sustained for at least 23 weeks. All ETEC strains used in design of the adhesin-tip MEFA, and five of five clinical ETEC strains were significantly (P &lt; 0.05) inhibited from adhesion to mammalian cells in culture.ConclusionsThese findings demonstrate that IgY targeting ETEC adhesin-tip MEFA have the potential to disrupt in vitro adherence of ETEC. A formulation containing adhesin-tip MEFA IgY can be considered a potential candidate for in vivo evaluation as prophylaxis of diarrheal diseases. Animal studies of this formulation are planned.