bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of channel height on the critical particle diameter in a deterministic lateral device
Authors: Bae Jae Hyun , Zhbanov Alexander , Yang Sung 
Published: November 2022

AbstractThe separation of biological cells or microorganisms in a liquid based on their size by deterministic lateral displacement is widely used in laboratories. The analytical equation for the critical diameter is derived under the assumption that flow between two posts is better described by flow in a rectangular tube than between parallel plates. The height position of the particle is an additional parameter that affects the critical diameter. Preliminary experiments were carried out on the separation of particles in deep and shallow microchannels. This study shows that the critical diameter is not a constant value for a given design but is different on each plane parallel to the top and bottom of the channel. The theoretical model was used to analyze experimental data on the separation of particles larger than 4.2 µm from particles ranging in size from 2.5 to 7.9 µm.
Vaccine management practices among healthcare workers in Morogoro, Tanzania: a cross-sectional study
Authors: Nestory Bonaventura , Anasel Mackfallen , Nyandwi Jean Baptiste , Asingizwe Domina 
Published: November 2022

Abstract
Background
Effective vaccine management is essential to maintain the quality of vaccines, minimise wastages, and prevent missed opportunities for vaccination at service delivery points.

Objectives
This study aims to assess vaccine management practices among vaccinators at health facilities in the Morogoro region, Tanzania.

Methodology
A descriptive cross-sectional study design involved health workers from 77 health facilities offering vaccination services. The study population consisted of vaccine handlers and vaccinators working in public health facilities in the Morogoro region. The vaccine management practices were assessed using data collected from ledgers and the Vaccine Information Management System (VIMS). The temperature records were downloaded from the Fridge-tag® 2 and Coldtrace5 devices.

Results
The findings indicated that 65 (84%) health facilities had functional refrigerators and are using power from 26 (34%), 28 (36%), and 23 (30%) of grid electricity, solar, and Liquefied Petroleum Gas (LPG), respectively. Besides, 27 (35%) health facilities have an alternative energy source as a backup. In general, healthcare workers had a good knowledge of cold chain management, including the World Health Organization recommended storage temperatures for vaccines. Furthermore, vaccine stockout was found in 12 (15.6%) health facilities for at least one antigen and 4 (5.1%) health facilities for all five antigens under observation. This current study also revealed that the average calculated vaccine wastage rates for DTP, Measles–Rubella and Rotavirus vaccines were 7%, 19%, and 15%, respectively. More than half of health workers did not perform monthly temperature data reviews. In addition, poor performance led to high wastage rates, including the Rotavirus vaccines, and a change in VVM to discard points. Finally, a small number of 5 (6.5%) health facilities consecutively reported temperature exposure beyond + 8 Celsius (between 5.9 and 281 h).

Conclusions
Healthcare workers’ vaccine and cold chain management knowledge were good for temperature data reading and documentation. However, the practices were poor for some health facilities. The gaps observed in this study inform health managers and policymakers toward establishing interventions to improve health workers' knowledge and practice, including mentorships, supervision, and training to guarantee that each child in all communities reaps the benefits of immunisation services.
Neuroleptic malignant syndrome: a diagnostic dilemma in an unconscious patient—a case report
Authors: Jain Swati , Jain Shruti , Talwar Vandana 
Published: November 2022

Abstract
Background
Neuroleptic malignant syndrome is a clinical condition which has been studied and described well. But history of the patient and the medications he is on are very important to make this diagnosis.

Case presentation
We report the case of a young male who presented with the typical features but lacked the history of medication, hence delaying our diagnosis formation. In-depth history taking is very important in patients who present with unusual symptoms.

Conclusions
Patients on long-term medications, who may develop some side effects due to medication, should always carry a medical card stating their medical history and medication being taken.
Multi-focus light-field microscopy for high-speed large-volume imaging
Authors: Zhang Yi , Wang Yuling , Wang Mingrui , Guo Yuduo , Li Xinyang , Chen Yifan , Lu Zhi , Wu Jiamin , Ji Xiangyang , Dai Qionghai 
Published: November 2022

AbstractHigh-speed visualization of three-dimensional (3D) processes across a large field of view with cellular resolution is essential for understanding living systems. Light-field microscopy (LFM) has emerged as a powerful tool for fast volumetric imaging. However, one inherent limitation of LFM is that the achievable lateral resolution degrades rapidly with the increase of the distance from the focal plane, which hinders the applications in observing thick samples. Here, we propose Spherical-Aberration-assisted scanning LFM (SAsLFM), a hardware-modification-free method that modulates the phase-space point-spread-functions (PSFs) to extend the effective high-resolution range along the z-axis by ~ 3 times. By transferring the foci to different depths, we take full advantage of the redundant light-field data to preserve finer details over an extended depth range and reduce artifacts near the original focal plane. Experiments on a USAF-resolution chart and zebrafish vasculatures were conducted to verify the effectiveness of the method. We further investigated the capability of SAsLFM in dynamic samples by imaging large-scale calcium transients in the mouse brain, tracking freely-moving jellyfish, and recording the development of Drosophila embryos. In addition, combined with deep-learning approaches, we accelerated the three-dimensional reconstruction of SAsLFM by three orders of magnitude. Our method is compatible with various phase-space imaging techniques without increasing system complexity and can facilitate high-speed large-scale volumetric imaging in thick samples.
How We Manage Newly Diagnosed Multiple Myeloma With Circulating Tumor Cells
Authors: van de Donk Niels W.C.J. 
Published: November 2022

The Oncology Grand Rounds series is designed to place original reports published in the Journal into clinical context. A case presentation is followed by a description of diagnostic and management challenges, a review of the relevant literature, and a summary of the authors’ suggested management approaches. The goal of this series is to help readers better understand how to apply the results of key studies, including those published in Journal of Clinical Oncology , to patients seen in their own clinical practice.Careful evaluation of peripheral blood for the presence of circulating plasma cells by morphologic assessment or by flow cytometric analysis is an essential component of the diagnostic workup in all patients with newly diagnosed multiple myeloma (MM) to timely differentiate between MM and primary plasma cell leukemia (pPCL), which is the most aggressive plasma cell dyscrasia. The improvement in survival over time is more modest in pPCL, compared with what has been achieved in MM. pPCL is currently defined by the presence of ≥ 5% circulating plasma cells. However, this cutoff is now challenged by new data, from three large cohorts of patients with newly diagnosed MM, showing that a threshold of 2% circulating tumor cells (CTCs) by flow cytometry can be used to identify a subset of patients with ultra-high-risk MM with comparable prognosis as patients with pPCL. These patients may benefit from more intensified first-line therapies, or from enrollment into specific clinical trials, designed for ultra-high-risk MM and pPCL. Apart from differentiating MM from pPCL, the quantification of CTCs is also useful for risk stratification in MM. The detection of CTCs above a threshold of 0.01%-0.07% (much lower than the threshold to define pPCL) appears to be an independent predictor of poor clinical outcomes in newly diagnosed MM. Additional studies, including transplant-ineligible patients or with incorporation of novel immunotherapies, are needed to identify a definitive prognostic CTC cutoff. The next step will be the incorporation of CTC detection into existing staging systems to improve risk stratification and treatment personalization.
The Missing Matter of Revolution: Hydroelectricity and the Terrain of Postcolonial Politics
Authors: Okoth Christine 
Published: November 2022

Abstract
Through readings of two novels that feature hydroelectric facilities—Peter Abrahams's A Wreath for Udomo and Namwali Serpell's The Old Drift—this article demonstrates how each text grapples in very different ways with the tensions between extractive infrastructures and revolutionary politics. Focusing on a hydroelectric facility yet to be constructed, A Wreath for Udomo reaches for the formal capacities of the novel to stage how the process of formal enclosure specific to and resulting from economic planning results in an analytic enclosure that slowly undoes the possibility of revolutionary anti-capitalism. The Old Drift enacts, I will suggest, an important alternative to the epistemological enclosure foreseen in Abrahams's much earlier novel. Serpell's novel leverages the critical capacity of the historical, genealogical novel to evade the analytical impediments produced by the structure of the hydroelectric dam and the form of economic thinking it both metonymizes and from which such projects result. By constructing parallel revolutionary methods on the levels of characters and readers and content and form, The Old Drift effectively recasts the problem of revolution not in terms of ideological contradiction, as Abrahams does, but as a tension between the constituent components of novelistic and revolutionary totality.
Negative E-cadherin expression on bone marrow myeloma cell membranes is associated with extramedullary disease
Authors: Hirao Maki , Yamazaki Kohei , Watanabe Kentaro , Mukai Kiyoshi , Hirose Shigemichi , Osada Makoto , Tsukada Yuiko , Kunieda Hisako , Denda Ryunosuke , Kikuchi Takahide , Sugimori Hiroki , Okamoto Shinichiro , Hattori Yutaka 
Published: November 2022

Background: The loss of E-cadherin expression and the induction of N-cadherin are known as hallmarks of the epithelial-to-mesenchymal transition, an essential initial step in the process of metastasis in solid tumors. Although several studies have reported expressions of these cadherins in patients with multiple myeloma (MM), their clinical significance is unknown as MM cells are non-epithelial. Methods: In this study, we examined the expression of E- and N-cadherins by immunohistochemistry using bone marrow (BM) biopsy specimens from 31 newly diagnosed MM patients and in subsequent biopsy specimens from six of these. Results: Negative E-cadherin expression on BM myeloma cell membranes was significantly associated with the presence of soft-tissue masses arising from bone lesions and breaking through the cortical bone, referred to as extramedullary disease (EMD). Conclusions: Given the aggressive nature of EMD, our study suggests that screening for E-cadherin using BM immunohistochemistry is one measure that could predict the development of EMD in patients with MM.
Morphometric study of the lumbar vertebrae in dried anatomical collections
Authors: Ashish Sharad , Kalluraya P. , Pai Mangala , Murlimanju B.V. , Rao Y. , Prabhu Latha , Agrawal Amit 
Published: November 2022

Background: The objective of this anatomical study was to perform the morphometry of dried lumbar vertebrae in human cadavers. Methods: This study utilized 200 adult human cadaveric dried lumbar vertebrae. The digital Vernier calipers was used to perform the measurements. The height, antero-posterior length, transverse length of the body of the vertebrae, interpedicular distance at the lateral ends, lamina length, height and thickness, superior and inferior articular facet height and width, mid sagittal and transverse diameter of vertebral foramen, height, width and thickness of the pars inter-articularis were measured. Results: The vertebral body’s anteroposterior length was more at the lower border than at the superior border (p < 0.01). The length of lamina was higher over the right in comparison to the left (p < 0.001). The height of lamina, width of inferior articular facet, diameter of lateral recess and thickness of pars inter-articularis were greater for the left sided specimens (p < 0.01). The statistical significance was not observed for the comparison of the remaining parameters (p > 0.05). Conclusion: This anatomical study offered several dimensions of lumbar vertebrae, which are essential in the surgical practice. The implants at the lumbar vertebrae need to be manufactured based on the anatomical dimensions of that particular sample population.
Leveraging biochemical reactions to unravel functional impacts of cancer somatic variants affecting protein interaction interfaces
Authors: Raimondi Francesco , Burkhart Joshua G. , Betts Matthew J. , Russell Robert B. , Wu Guanming 
Published: November 2022

Background: Considering protein mutations in their biological context is essential for understanding their functional impact, interpretation of high-dimensional datasets and development of effective targeted therapies in personalized medicine. Methods: We combined the curated knowledge of biochemical reactions from Reactome with the analysis of interaction-mediating 3D interfaces from Mechismo. In addition, we provided a software tool for users to explore and browse the analysis results in a multi-scale perspective starting from pathways and reactions to protein-protein interactions and protein 3D structures. Results: We analyzed somatic mutations from TCGA, revealing several significantly impacted reactions and pathways in specific cancer types. We found examples of genes not yet listed as oncodrivers, whose rare mutations were predicted to affect cancer processes similarly to known oncodrivers. Some identified processes lack any known oncodrivers, which suggests potentially new cancer-related processes (e.g. complement cascade reactions). Furthermore, we found that mutations perturbing certain processes are significantly associated with distinct phenotypes (i.e. survival time) in specific cancer types (e.g. PIK3CA centered pathways in LGG and UCEC cancer types), suggesting the translational potential of our approach for patient stratification. Our analysis also uncovered several druggable processes (e.g. GPCR signalling pathways) containing enriched reactions, providing support for new off-label therapeutic options. Conclusions: In summary, we have established a multi-scale approach to study genetic variants based on protein-protein interaction 3D structures. Our approach is different from previously published studies in its focus on biochemical reactions and can be applied to other data types (e.g. post-translational modifications) collected for many types of disease.
Multi-layer modelling of masonry structures strengthened through textile-reinforced mortar
Authors: Boem Ingrid 
Published: November 2022

Background Textile-reinforced mortar (TRM) is an innovative strategy for the reduction of the seismic vulnerability of existing masonry buildings consisting in the application on the masonry surface, of a mortar coating with fiber-based grids or textiles embedded. The paper presents the calibration and application of a simplified modelling approach, based on multi-layered elements, for the simulation of existing masonry elements and structures strengthened through TRM. Methods The strengthened masonry is modelled by using 20-nodes brick elements formed by a stacking sequence of layers representing the different material components (the masonry, the mortar coating and the embedded reinforcement). The nonlinear behavior of the materials is considered and calibrated on the basis of experimental characterization tests on individual components available in the literature. The simplified assumption of perfect bond among layers is considered. Results Non-linear static analyses are performed on samples of increasing complexity: elementary panels, structural elements (piers and spandrels) and a pilot building. The results of some tests on TRM strengthened masonry, available in the literature, are considered to assess the model reliability in terms of capacity curves and collapse mode. The model is capable of detecting the typical failure mechanism of existing masonry, namely the diagonal cracking, the in-plane bending and the out-of-plane bending and is able to detect the activation also of mixed failure modes, that often occur in actual configurations. Conclusions Given the coarse mesh size and the smear plasticization assumption, the model is not suitable for the rigorous reproduction of individual cracks but represents a good compromise between the goal to grasp the structural performances at the wide scale, including failure modes, and the analysis optimization.
Las voces de Lautréamont
Authors: Mallart Myriam 
Published: November 2022

The history of the reception in Castilian of Lautréamont’s Chants du Maldoror, a forgotten book then, intertwines with it’s rediscovery by André Breton and the surrealist movement. Both translations of the book, which are very different from a linguistic point of view, above all in what concerns the critical work surrounding the text, happen to coincide with two essential moments of the surrealist’s reception: the “Roaring Twenties”, which were years of an enormous surrealist activity, and the sixties, a decade in which the movement itself became part of the “History of Literature”. In the foreword of 1925’s version, Ramón Gómez de la Serna nourishes from surrealist’s knowledge and opinions on Lautréamont’s figure, while forty years later, Peligrini’s introduction and notes show that the author of the Chants was already considered a “classic".
AGAINST SPANISH CONSCIENCE’: THE TRANSLATION OF NORTH-AMERICAN CLASSICS IN POST-WAR SPAIN (1950S & 1960S)
Authors: Teresa Requena Gemma López 
Published: November 2022

The period before the Spanish Civil War witnessed some translations into Catalan of North-American authors such as Walt Whitman, Mark Twain, Edgar Allan Poe and Nathaniel Hawthorne. It is over the 1930s, however, that other big names of North-American literature –such as William Faulkner and Ernest Hemingway- reach high levels of popularity on Spanish soil. What happens much later with the reception of these authors? Our article will explore the translations of these and other North-American authors which appeared over the end of the Spanish Civil War to the end of the 1950s, a period of cnsolidation of the United States as a global economic power. Our proposal is to research the selection of titles edited and translated over these two decades (40s and 50s) with a view of demonstrating that they conform an intricate wave of thought on the part of vocational editors who took care of every single detail in the editing process, and who had to confront serious logistic and ideological problems to boot. In order to carry out our research, we have been working with the catalogues of Janés, Caralt, Seix Barral and Destino.
CROLLA, Adriana Cristina (UNL): Traducción literaria en Argentina. Tradición, matrices culturales y tra-dicciones en perspectiva comparada
Authors: Crolla Adriana Cristina 
Published: November 2022

El advenimiento de la aldea global y los procesos acaecidos durante la segunda mitad del S.XX han provocado un auge notable de estudios y una redefinición de función que cumple la traducción como práctica social e indicador de tradiciones de lecturas y como el paradigma de toda práctica de intermediación lingüística, semiótica y cultural. Re-visión sobre todo de: 1) el papel del traductor en las operaciones de escritura y re-escritura en el entramado cultural; 2) la compleja relación que se establece entre textos y versiones, 3) la incidencia de la traducción en la conformación o redefinición de una tradición o sistema literario y 4) el papel que juegan los marcos culturales de partida y de llegada en la determinación de su validación. Desde los parámetros de los estudios comparados es interesante analizar estas operaciones por el modo en que, aún la traducción intralingüística, permite hacer visibles fenómenos de interferencia y de intraducibilidad que pueden sólo ser explicados en función del contexto y de las matrices culturales que dan marco de referencia. Proponemos entonces, desde el juego homofónico de "traducción, tradición y tra-dicción", analizar algunos casos paradigmáticos que ponen de relieve la incidencia de las matrices culturales europeas en la conformación idiosincrática argentina y los efectos diversos de lectura que este fenómeno inter-fiere.
La traducción y su papel hibridizante dentro de la semiosfera: Fenollosa – Hearn – Pound – Noguchi
Authors: Penas-Ibáñez Beatriz 
Published: November 2022

En este artículo tomaremos, como punto de partida, el factor diversidad quecaracteriza la semiosfera (Lotman [1984] 2005) y define el complejo entramado derelaciones de naturaleza intracultural que prefiguran y posibilitan la relaciónintercultural, especialmente por medio de la traducción. La semiosfera es el sistemaen el cual los textos estándar de la cultura ocupan lugar preeminente en la jerarquíaque define el segmento educado (High) de esa cultura frente a otros segmentos osubculturas (Low). Dentro de una semiosfera el estándar es la norma de referenciapara la interpretación del valor simbólico de la diferencia subcultural (High vs. Low)existente en la intracultura y que condiciona la forma de su transferencia a otracultura. Por una parte incidiremos en la necesidad radical de reconceptualizar latraducción per se como proceso posibilitador de la comprensión de lo diverso desdeel interior del discurso y a través de lo diverso del discurso y, por tanto, comoproceso de gestión discursiva tendente a la convergencia interpretativa (intertextual,intersubjetiva, intercultural) de enunciados en principio divergentes en la forma enque sus diferentes códigos verbales y culturales articulan el sentido. Por otra parteseñalaremos la importancia del traductor individual dentro de estos procesos.Plantearemos el rol primordial que juegan los traductores en la modernizaciónde sus correspondientes semiosferas, y lo haremos a través de un ejemplo muysignificativo que relaciona el nacimiento del Imaginismo y Modernismo Anglonorteamericanoal cierre de la época Meiji en Japón o de la etapa Victoriana en GranBretaña. No fue accidental que, tras varias décadas de nueva producción detraducciones (del japonés al Inglés y del Inglés al Japonés) por parte de traductorescomo Noguchi, Hearn, Fenollosa, o Ezra Pound, tuviese lugar la eclosión de unasliteraturas, la Japonesa y la Anglo-norteamericana, plenamente modernizadas yrenovadoras. Mientras traducían, estos traductores fueron aprendiendo de latextualidad Fuente a escribir textos Meta cuyas formas híbridas les enseñaban, a ellos y a sus compañeros de profesión literaria, a renovar los estándares de sussemiosferas nativas.
Simulation on a dispersion-managed 4H-SiC on insulator waveguide for infrared supercontinuum generation
Authors: Zhou Jian , Kang Ruyan , Cheng Pengpeng , Liu Zehan , Zhao Jia , Zuo Zhiyuan 
Published: November 2022

We demonstrate infrared supercontinuum generation in 4H-SiC on
insulator slab waveguides. The effect of waveguide geometry parameters
on dispersion is investigated to switch the zero-dispersion wavelength
close to the pump wavelength. The 1 cm long 4H-SiC waveguide is
pumped by 100 fs pulses at 1550 nm with 2000 W
peak power, and the generated supercontinuum extends from

∼

1000

to

∼

3560

n
m

(at 20 dB level). This work
shows that 4H-SiC has significant potential as on-chip photonic
sources for spectroscopic applications in infrared wavelengths.