bluuebunny/crossref_metadata_2025_split huggingface dataset:
A standardized marking procedure for ENT operations to prevent wrong-site surgery: development, establishment and subsequent evaluation among patients and medical personnel
Authors: Rohrmeier Christian , Abudan Al-Masry Narmeen , Keerl Rainer , Bohr Christopher , Mueller Steffen 
Published: June 2022

Abstract
Purpose
Wrong-site surgeries are rare but potentially serious clinical errors. Marking the surgical site is crucial to preventing errors, but is hindered in the ENT field by the presence of many internal organs. In addition, there is no standardized marking procedure.

Methods
Here, an ENT surgical-marking procedure was developed and introduced at a clinic. The procedure was evaluated through anonymized questionnaires. This study was conducted over a 6-month period by interviewing patients and, at the beginning and end of this period, doctors and other surgical staff.

Results
The internal organ-marking problem was solved by applying a fixed abbreviation for each procedure onto the shoulder in addition to marking the skin surface as close to the organ as possible. The procedure was described as practicable by 100% of the interviewees; 75% of the ENT physicians and 96.3% of the other surgical staff considered the procedure highly important for preventing site confusion, and 75% of the physicians had a consequently greater feeling of safety. Of the 248 patients surveyed, 96.0% considered the marking procedure useful, and 75.8% had a consequently greater feeling of safety. For 52.0%, the marking reduced their fear of the operation.

Conclusions
For the first time, a standardized procedure was developed to mark the site of ENT surgery directly, uniformly and safely on patients. The procedure was judged to be useful and practicable and was also deemed crucial for preventing site confusion. Patients felt safer and less fearful of the operation due to the marking.
Usefulness of Telemedicine for Disabled Children Receiving Feeding Therapy
Authors: Tamura Fumiyo , Kikutani Takeshi , Machida Reiko , Isoda Tomoko , Hobo Kimiko , Yamada Hiroyuki , Kodama Miho , Genkai Sae , Mizukami Miki , Tanaka Yuko , Sakuda Taeko , Furuya Hiroyasu , Takahashi Noriaki 
Published: June 2022

AbstractWe performed a retrospective cohort study using medical records of 374 pediatric patients who visited a university dental clinic specializing in dysphagia rehabilitation in Japan between 2019 and 2020 to clarify the usefulness of telemedicine among disabled children receiving feeding therapy. The primary outcome was the feeding developmental stage confirmed at the final evaluation. Propensity score matching was performed between individuals in two treatment groups (in-person and telemedicine) before the final analysis using patients’ age, sex, primary disease, gross motor function, and feeding developmental stage as covariates. A total of 36 patients were enrolled in each of the in-person and telemedicine groups. The initial evaluation for the propensity score matched population using the χ2 test showed no significant difference between the two groups in any parameter. The feeding developmental stage evaluated at the final evaluation using the Wilcoxon signed-rank test significantly improved compared with the stage at the initial evaluation in both groups (in-parson group, p = 0.007; telemedicine group, p = 0.013). The difference in level achieved at the final evaluation revealed that the most common level was “unchanged,” followed by “improvement by one level” in both groups, indicating that there was no significant difference in the efficacy of feeding therapy between the two groups (p = 0.314). Our results show that telemedicine can achieve the same therapeutic outcomes as in-person therapy to improve feeding function in children with disabilities when receiving feeding therapy.
A retrospective clinical study of fixed tooth- and implant-supported prostheses in titanium and cobalt-chromium-ceramic: 5–9-year follow-up
Authors: Nilsson Sheida , Stenport Victoria Franke , Nilsson Marco , Göthberg Catharina 
Published: June 2022

Abstract

Objectives
The aim of this retrospective study was to evaluate the clinical outcome of fixed tooth- and implant-supported protheses manufactured in porcelain veneered cobalt-chromium (CoCr) or titanium with a follow-up period of 5–9 years.

Materials and methods
This study included 63 patients with a total of 86 fixed dental protheses (FDPs) (53 implant-supported and 33 tooth-supported). In total, 67 were short-span FDPs (3–5 units) and 19 were long-span FDPs (6–12 units). The FDPs were evaluated using a modified version of the California Dental Association (CDA).

Results
The binary regression analysis indicated that neither CoCr nor titanium had a statistically significant effect on the odds of success or survival of either tooth- or implant-supported FDPs. However, the success of FDPs was negatively affected by greater FDP length and general tooth wear. The survival of FDPs was negatively affected by increased FDP longevity.

Conclusions
This study found no statistically significant effect on the odds of success and survival outcomes for any combination of tooth-supported, implant-supported, porcelain-veneered CoCr, or porcelain-veneered titanium FDPs. As the number of FDPs was limited, the results should be interpreted with caution.

Clinical relevance
This study shows that the choice between CoCr porcelain and titanium porcelain in fixed protheses did not have a statistically significant effect on the outcome.
From Intra-plant to Regional Scale: June Temperatures and Regional Climates Directly and Indirectly Control Betula nana Growth in Arctic Alaska
Authors: Buchwal Agata , Bret-Harte M. Syndonia , Bailey Hannah , Welker Jeffrey M. 
Published: June 2022

AbstractTundra shrubs reflect climate sensitivities in their growth-ring widths, yet tissue-specific shrub chronologies are poorly studied. Further, the relative importance of regional climate patterns that exert mesoscale precipitation and temperature influences on tundra shrub growth has been explored in only a few Arctic locations. Here, we investigate Betula nana growth-ring chronologies from adjacent dry heath and moist tussock tundra habitats in arctic Alaska in relation to local and regional climate. Mean shrub and five tissue-specific ring width chronologies were analyzed using serial sectioning of above- and below-ground shrub organs, resulting in 30 shrubs per site with 161 and 104 cross sections from dry and moist tundra, respectively. Betula nana growth-ring widths in both habitats were primarily related to June air temperature (1989–2014). The strongest relationships with air temperature were found for ‘Branch2’ chronologies (dry site: r = 0.78, June 16, DOY = 167; moist site: r = 0.75, June 9, DOY = 160). Additionally, below-ground chronologies (‘Root’ and ‘Root2’) from the moist site were positively correlated with daily mean air temperatures in the previous late-June (‘Root2’ chronology: r = 0.57, pDOY = 173). Most tissue-specific chronologies exhibited the strongest correlations with daily mean air temperature during the period between 8 and 20 June. Structural equation modeling indicated that shrub growth is indirectly linked to regional Arctic and Pacific Decadal Oscillation (AO and PDO) climate indices through their relation to summer sea ice extent and air temperature. Strong dependence of Betula nana growth on early growing season temperature indicates a highly coordinated allocation of resources to tissue growth, which might increase its competitive advantage over other shrub species under a rapidly changing Arctic climate.
Extended reality technologies in small and medium-sized European industrial companies: level of awareness, diffusion and enablers of adoption
Authors: Jalo Henri , Pirkkalainen Henri , Torro Osku , Pessot Elena , Zangiacomi Andrea , Tepljakov Aleksei 
Published: June 2022

AbstractAugmented reality (AR) and virtual reality (VR), collectively referred to as “extended reality” (XR), have begun to diffuse in industry. However, the current levels of awareness, perceived limitations, and use of AR and VR, as well as the potential differences on these aspects between these technologies are still not well known. Moreover, it is unknown whether small and medium-sized enterprises (SMEs) differ from large companies on these issues. This research employed a mixed methods research design to address this gap by carrying out a cross-sectional survey (n = 208) to gauge European industrial companies’ level of AR and VR awareness and adoption, and by interviewing 45 companies in nine European countries in order to identify critical enabling factors in the adoption of XR for SMEs. Results show no statistical difference between the respondents’ perceptions toward AR and VR or in their use levels. Thus, examining AR and VR under the umbrella term XR seems justified, especially in the context of their organizational use. However, larger companies were found to be using XR more than SMEs. Analysis of interviews based on the technology–organization–environment framework also yielded several enabling factors affecting XR adoption and specified whether they are particularly highlighted in the SME context. Overall, this paper contributes to XR research by providing a holistic multi-country overview that highlights key issues for managers aiming to invest in these technologies, as well as critical organizational perspectives to be considered by scholars.
Usefulness of an S-1 dosage formula: an exploratory analysis of randomized clinical trial (JCOG1001)
Authors: Kawakami Takeshi , Mizusawa Junki , Hasegawa Hiroko , Imazeki Hiroshi , Kano Kazuki , Sato Yuya , Iwasa Satoru , Takiguchi Shuji , Kurokawa Yukinori , Doki Yuichiro , Boku Narikazu , Yoshikawa Takaki , Terashima Masanori 
Published: June 2022

Abstract
Background
The blood concentration of S-1 and adverse events are affected by renal function. Herein, an S-1 dosage formula was developed based on renal function, indicating the dose for a target blood concentration. This study aimed to explore the usefulness of the formula in adjuvant chemotherapy for gastric cancer.

Methods
In this ad hoc analysis of the JCOG1001 trial, which evaluated the role of bursectomy for resectable gastric cancer, the recommended dose of S-1 was calculated using the following formula: 1447.8 × (14.5 + 0.301 × CLcr + 8.23 × SEX [male = 1, female = 0]) × body surface area (BSA) (mg/day). Patients were divided into three groups by comparing the initial S-1 dose determined using BSA with the dose recommended by the formula: underdose (UD), equal dose (ED), and overdose (OD).

Results
Among 686 eligible patients, 58, 304, and 324 patients were classified into the UD, ED, and OD groups. The patients’ characteristics in the UD/ED/OD groups were median age (53.5/64.0/67.5 years), male sex (98.3%/75.3%/58.0%), and median BMI (24.8/22.8/22.3), respectively. The planned 1-year adjuvant S-1 therapy was completed in 74.1%/73.7%/68.5%, dose reduction was required in 8.6%/21.1%/30.6%, and treatment schedule was altered in 8.6%/17.1/19.8% in the UD/ED/OD groups, resulting in the 5-year overall survival rates of 77.3%/74.3%/77.0%, respectively. The incidences of grade > 3 anemia, thrombocytopenia, diarrhea, stomatitis, and anorexia were significantly higher in the OD group than in the ED and UD groups.

Conclusions
Dose optimization using an S-1 dosage formula can potentially reduce grade ≥ 3 adverse events for overdosed patients.
Neural Network Detection of Pacemakers for MRI Safety
Authors: Thurston Mark Daniel Vernon , Kim Daniel H , Wit Huub K 
Published: June 2022

AbstractFlagging the presence of cardiac devices such as pacemakers before an MRI scan is essential to allow appropriate safety checks. We assess the accuracy with which a machine learning model can classify the presence or absence of a pacemaker on pre-existing chest radiographs. A total of 7973 chest radiographs were collected, 3996 with pacemakers visible and 3977 without. Images were identified from information available on the radiology information system (RIS) and correlated with report text. Manual review of images by two board certified radiologists was performed to ensure correct labeling. The data set was divided into training, validation, and a hold-back test set. The data were used to retrain a pre-trained image classification neural network. Final model performance was assessed on the test set. Accuracy of 99.67% on the test set was achieved. Re-testing the final model on the full training and validation data revealed a few additional misclassified examples which are further analyzed. Neural network image classification could be used to screen for the presence of cardiac devices, in addition to current safety processes, providing notification of device presence in advance of safety questionnaires. Computational power to run the model is low. Further work on misclassified examples could improve accuracy on edge cases. The focus of many healthcare applications of computer vision techniques has been for diagnosis and guiding management. This work illustrates an application of computer vision image classification to enhance current processes and improve patient safety.
Ang Ating Mata: Disparities in Eye Health Knowledge, Attitudes and Practices among Older Adult Filipino-Americans in the San Francisco Bay Area Counties
Authors: Jiro Marycon Chin , Sigua Michael , Ivey Susan L. , Maus Marlon , Hennein Lauren , Dio Migel , Cocohoba Jennifer 
Published: June 2022

AbstractFilipino-Americans are the third largest Asian-American population, with a median age of 44. However, there is limited literature focusing on the group’s ophthalmic care engagement. Timely eye examinations and outreach are necessary to reduce visual impairment in this older community. To assess eye care knowledge, attitudes, and practices, we conducted a cross-sectional study surveying Filipino-Americans within the nine San Francisco Bay Area counties. Associations between primary outcomes and sociodemographic factors were analyzed using chi-squared analysis and student’s T-test. In our convenience sample of 256 surveys, a majority of participants are receiving appropriate eye care; those that lacked health and eye insurance, immigrated and are lower income did not receive optimal eye care. Study participants also demonstrated a lack of awareness of eye diseases and risk factors. Our results suggest that culturally sensitive eye health education materials are lacking and should be made accessible for this large and rapidly growing population.
Antibodies against complement component C5 prevent antibody-mediated rejection after lung transplantation in murine orthotopic models with skin-graft-induced pre-sensitization
Authors: Shiina Yuki , Suzuki Hidemi , Hata Atsushi , Kaiho Taisuke , Matsumoto Hiroki , Toyoda Takahide , Sakairi Yuichi , Wada Hironobu , Motohashi Shinichiro , Yoshino Ichiro 
Published: June 2022

Abstract
Objective
Antibody-mediated rejection (AMR) could induce acute or chronic graft failure during organ transplantation. Several reports have shown that anti-C5 antibodies are effective against AMR after kidney transplantation. However, few reports have assessed the efficacy of anti-C5 antibodies against AMR after lung transplantation. Therefore, this study aimed to evaluate the efficacy of this novel therapy against AMR after lung transplantation.

Methods
BALB/c and C57BL/6 mice were used as donors and recipients. One group was pre-sensitized (PS) by skin transplantation 14 days before lung transplantation. The other group was non-sensitized (NS). Orthotopic left-lung transplantation was performed in both groups. Animals were killed at 2 or 7 days after lung transplantation and evaluated for histopathology, C4d immunostaining, and serum donor-specific antibodies (DSAs) (n = 5 per group). Isograft (IS) models with C57BL/6 mice were used as controls. To evaluate the efficacy of C5 inhibition, other animals, which received similar treatments to those in the PS group, were treated with anti-C5 antibodies, cyclosporine/methylprednisolone, anti-C5 antibodies/cyclosporine/methylprednisolone, or isotype-matched irrelevant control monoclonal antibodies (n = 5 per group).

Results
Two days after lung transplantation, the NS group exhibited mild, localized graft-rejection features (rejection score: 0.45 ± 0.08, p = 0.107). The PS group exhibited AMR features with a significantly higher rejection score (2.29 ± 0.42, p = 0.001), C4d vascular-endothelium deposition, and substantial presence of serum DSA. On day 7 after lung transplantation, both groups showed extensive graft alveolar wall destruction, and high acute-rejection scores. Mice receiving anti-C5 antibodies or anti-C5/antibodies/cyclosporine/methylprednisolone demonstrated significantly lower acute-rejection scores (0.63 ± 0.23, p = 0.002; 0.59 ± 0.22, p = 0.001, respectively) than those receiving isotype control antibodies.

Conclusions
Murine orthotopic allograft lung transplant models met the clinical diagnosis and pathogenesis classification criteria of AMR. In these models, anti-C5 antibodies suppressed AMR. Therefore, anti-C5 therapy may be effective against AMR after lung transplantation.
Radon concentration and exhalation rate for granitic rocks, Central Eastern Desert, Egypt
Authors: Salaheldin Ghada , Elhaddad Mervat , Sidique Essam 
Published: June 2022

Abstract
The present work deals with radon pollution arising from granitic rocks using an Alpha Guard radon monitor. Forty-four granitic samples were collected from five sites located in the Central part of the Eastern Desert of Egypt. The minimum to maximum concentration of radon for the rocks of Gebel (mountain) El-Missikat MS, El-Gidamy GD, RieEl-Garra RG, El-Aradiya AR, and Kab-Amira KA were 49,597 ± 8773 to 236,029 ± 22,397 Bq m−3, 39,658 ± 8341 to 188,666 ± 20,545 Bq m−3, 39,854 ± 7645 to 91,393 ± 13,429 Bq m−3, 45,951 ± 9488 to 121,935 ± 14,869 Bq m−3, and 33,209 ± 6989 to 251,398 ± 25,759 Bq m−3, respectively. The surface and mass exhalation rates, the emanation coefficient, and annual effective dose (indoors) were calculated for all the studied samples. The average value of radon concentration in the collected samples was higher than the national reference level of 300 Bq m−3 recommended by ICRP corresponding to an annual effective dose of 4 mSv at work and 14 mSv at home. The measured values for the rock samples studied in the five sites surpassed the world average of soil in areas with normal levels of radioactivity. The MS granitic samples showed a potential radiological risk for human beings, therefore, it is important to carry out a detailed monitoring program for dose assessment.
Geoelectric and mineralogical studies for foundation soil characterization in new Luxor city, Upper Egypt
Authors: Elkhateeb Sayed Omer , Dosoky Wael , Mohamed Abdelnasser , Abbas Mahmoud A. 
Published: June 2022

AbstractThe new Luxor city was proposed by the Egyptian government as a new constructional and building site in order to face the increasing population density around the two banks of the river Nile. It is important prior construction of buildings to characterize the foundation soil. So, vertical electrical resistivity survey and mineralogical investigation were conducted for this purpose. The results obtained from the interpretation of the sounding data indicate that the lithological succession of the study area consists of four geoelectric layers. The top layer corresponds to the surface loose sediments of conglomerate, gravel, and sand. The second geoelectric layer is composed of sand and gravel. The third layer is composed of silty clay, sandy clay, and clayey sand. The fourth geoelectric layer is composed of dry sandstone. The X-ray diffraction (XRD) results of samples collected from the clay-rich layer revealed the presence of smectite mineral as predominate clay minerals which is characterized by its swell potentiality on wetting. Accordingly, the clay zone recorded within the third layer must be taken into consideration during designing the foundations at new Luxor city especially this layer was located at shallow depth range between 1.6 and 7.5 m and attains a relatively big thickness that reach up to 33.5 m in some parts. This study emphasizes the importance of the integration of geophysical investigation and mineralogical analysis of the foundation soil for optimal characterization of a site.
System nutrient dynamics in orchards: a research roadmap for nutrient management in apple and kiwifruit. A review
Authors: Gentile Roberta M. , Boldingh Helen L. , Campbell Rebecca E. , Gee Megan , Gould Nick , Lo Peter , McNally Sam , Park Kye Chung , Richardson Annette C. , Stringer Lloyd D. , Vereijssen Jessica , Walter Monika 
Published: June 2022

AbstractAs agricultural intensification affects global environmental change, a redesign of our food production systems towards practices that replace external inputs with inbuilt ecosystem services is needed. Specifically, human-induced changes to biogeochemical flows of nitrogen (N) cycling exceed the proposed planetary boundaries, highlighting a priority area for reducing nutrient inputs in agricultural production systems. A new understanding of nutrient interactions in the complete agroecosystem will allow us to better predict and mitigate the consequences of anthropogenic environmental changes compared with a reductionist approach. Here, we review for the first time system-level nutrient interactions, particularly N, in perennial horticulture using high-producing kiwifruit and apple crops grown in New Zealand as a basis to identify critical knowledge gaps and prioritize new research. The major points identified are (1) current nutrient guidelines are from the 1980s to the early 2000s and do not take into account substantial production changes since that time; (2) few studies construct complete nutrient budgets of all sources and losses; (3) nutrient loss estimates are generally low relative to those from other agricultural land uses; (4) there is a lack of studies which address nutrient interactions between above- and below-ground food webs in perennial horticultural crops; (5) there is contradictory literature where fertilizer has been found both to increase and to decrease plant chemical signaling and defense mechanisms. New tools are emerging to improve orchard nutrient management, including advances in fertilizer application techniques, new methods to monitor plant and soil nutrients, and utilizing genetic variability to breed cultivars with improved nutrient use efficiency. To reduce adverse nutrient effects on the environment, new research is needed, addressing the relationships between carbon and nutrients and nutrient demands in modern fruit cultivars and growing systems; the nutrient balance for perennial horticultural crops considering all inputs and outputs; and interactions of the above- and below-ground nutrient flows in orchard food webs.