bluuebunny/crossref_metadata_2025_split huggingface dataset:
Individual Brain Morphological Connectome Indicator Based on Jensen–Shannon Divergence Similarity Estimation for Autism Spectrum Disorder Identification
Authors: Yi Ting , Wei Weian , Ma Di , Wu Yali , Cai Qifang , Jin Ke , Gao Xin 
Published: June 2022

BackgroundStructural magnetic resonance imaging (sMRI) reveals abnormalities in patients with autism spectrum syndrome (ASD). Previous connectome studies of ASD have failed to identify the individual neuroanatomical details in preschool-age individuals. This paper aims to establish an individual morphological connectome method to characterize the connectivity patterns and topological alterations of the individual-level brain connectome and their diagnostic value in patients with ASD.MethodsBrain sMRI data from 24 patients with ASD and 17 normal controls (NCs) were collected; participants in both groups were aged 24–47 months. By using the Jensen–Shannon Divergence Similarity Estimation (JSSE) method, all participants’s morphological brain network were ascertained. Student’s t-tests were used to extract the most significant features in morphological connection values, global graph measurement, and node graph measurement.ResultsThe results of global metrics’ analysis showed no statistical significance in the difference between two groups. Brain regions with meaningful properties for consensus connections and nodal metric features are mostly distributed in are predominantly distributed in the basal ganglia, thalamus, and cortical regions spanning the frontal, temporal, and parietal lobes. Consensus connectivity results showed an increase in most of the consensus connections in the frontal, parietal, and thalamic regions of patients with ASD, while there was a decrease in consensus connectivity in the occipital, prefrontal lobe, temporal lobe, and pale regions. The model that combined morphological connectivity, global metrics, and node metric features had optimal performance in identifying patients with ASD, with an accuracy rate of 94.59%.ConclusionThe individual brain network indicator based on the JSSE method is an effective indicator for identifying individual-level brain network abnormalities in patients with ASD. The proposed classification method can contribute to the early clinical diagnosis of ASD.
A Prospective, Cohort Study of SITOIGANAP to Treat Glioblastoma When Given in Combination With Granulocyte-Macrophage Colony-Stimulating Factor/Cyclophosphamide/Bevacizumab/Nivolumab or Granulocyte-Macrophage Colony-Stimulating Factor/Cyclophosphamide/Bevacizumab/Pembrolizumab in Patients Who Failed Prior Treatment With Surgical Resection, Radiation, and Temozolomide
Authors: Bota Daniela A. , Taylor Thomas H. , Lomeli Naomi , Kong Xiao-Tang , Fu Beverly D. , Schönthal Axel H. , Singer Samuel , Blumenthal Deborah T. , Senecal Frank M. , Linardou Helena , Rokas Evangelos , Antoniou Dimitris G. , Schijns Virgil E. J. C. , Chen Thomas C. , Elliot Joseph , Stathopoulos Apostolos 
Published: June 2022

BackgroundGlioblastoma (GBM) is the most common primary, malignant brain tumor in adults and has a poor prognosis. The median progression-free survival (mPFS) of newly diagnosed GBM is approximately 6 months. The recurrence rate approaches 100%, and the case-fatality ratio approaches one. Half the patients die within 8 months of recurrence, and 5-year survival is less than 10%. Advances in treatment options are urgently needed. We report on the efficacy and safety of a therapeutic vaccine (SITOIGANAP: Epitopoietic Research Corporation) administered to 21 patients with recurrent GBM (rGBM) under a Right-to-Try/Expanded Access program. SITOIGANAP is composed of both autologous and allogeneic tumor cells and lysates.MethodsTwenty-one patients with rGBM received SITOIGANAP on 28-day cycles in combination with granulocyte-macrophage colony-stimulating factor (GM-CSF), cyclophosphamide, bevacizumab, and an anti-programmed cell death protein-1 (anti-PD-1) monoclonal antibody (either nivolumab or pembrolizumab).ResultsThe mPFS was 9.14 months, and the median overall survival (mOS) was 19.63 months from protocol entry. Currently, 14 patients (67%) are at least 6 months past their first SITOIGANAP cycle; 10 patients (48%) have received at least six cycles and have a mOS of 30.64 months and 1-year survival of 90%. The enrollment and end-of-study CD3+/CD4+ T-lymphocyte counts strongly correlate with OS.ConclusionsThe addition of SITOIGANAP/GM-CSF/cyclophosphamide to bevacizumab and an anti-PD-1 monoclonal antibody resulted in a significant survival benefit compared to historic control values in rGBM with minimal toxicity compared to current therapy.
Effect of Exercise Training on Serum Transaminases in Patients With Nonalcoholic Fatty Liver Disease: A Systematic Review and Meta-Analysis
Authors: Hong Feng , Liu Yubo , Lebaka Veeranjaneya Reddy , Mohammed Arifullah , Ye Weibing , Chen Biqing , Korivi Mallikarjuna 
Published: June 2022

Background/Purpose: Nonalcoholic fatty liver disease (NAFLD) constitutes a spectrum of liver diseases associated with various metabolic disorders. Exercise interventions reportedly manage the clinical outcomes of NAFLD, but their efficacy depends on exercise as well as characteristics of patient. We hypothesized that exercise could alleviate the elevated transaminases level, which may be associated with the characteristics of patients (age/bodyweight/sex) or exercise variables (frequency/intensity/duration). Therefore, we examined the effect of exercise on serum transaminases, and identified the variables influencing transaminases in NAFLD patients.Methods: Article search was conducted using electronic databases (PubMed, Web of Science, EMBASE, ScienceDirect, Google Scholar) until December 2021. Studies that involved examination and comparison of the effect of an exercise intervention on alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels in NAFLD/nonalcoholic steatohepatitis patients were included. We calculated pooled effect upon a meta-analysis, determined correlations (between transaminases and characteristics of patients/exercise) by meta-regression, and assessed the influencing variable through subgroup analysis.Results: A total of 18 studies (22 trials) with 1098 NAFLD patients (exercise = 568; control = 530) were included. The pooled outcomes revealed that exercise intervention significantly decreased both ALT (p = 0.004) and AST (p = 0.001) levels in NAFLD patients. Meta-regression analysis showed decreased ALT (coef. = 1.138, p &lt; 0.01) and AST (coef. = 0.459, p = 0.041) after intervention was correlated with the age of patients. Particularly, patients aged 30–39 years (MD: −25.89 U/L, 95% CI: −36.40 to −15.37, p &lt; 0.00001) and 40–49 years (MD: −12.17 U/L, 95% CI: −20.38 to −3.96, p = 0.004) represented a substantial decrease in ALT levels. Additionally, the 50–59 years age group tended to have decreased ALT levels (MD: −3.94 U/L, 95% CI: −8.19 to 0.31, p = 0.07); however, patients above 60 years did not respond (p = 0.92) to exercise intervention. In contrast, exercise-induced AST reduction was found in only the 30–39 years age group (MD: −11.92 U/L, 95% CI: −16.78 to −7.06, p &lt; 0.00001) and not in patients under the 40–49 (p = 0.19), and 50–59 groups (p = 0.12) and above 60 years (p = 0.15).Conclusion: Our findings suggest that the age of NAFLD patients may be an important variable in improving the levels of serum transaminases, and clinically young patients may have greater benefits from exercise than older patients.
Anticipated Self and Public Stigma in Suicide Prevention Professionals
Authors: Roškar Saška , Kralj Domen , Andriessen Karl , Krysinska Karolina , Vinko Matej , Podlesek Anja 
Published: June 2022

BackgroundStigma about mental illness—both public and self—is one of the most important factors hindering help-seeking. Stigma can occur during an acute episode of mental illness or be anticipatory. One group affected by stigma, but often neglected, is mental health professionals. This study examined the anticipated form of mental-illness and help-seeking self-stigma and the anticipated form of public stigma of suicidal behavior among members of the International Association for Suicide Prevention. We hypothesized that suicidologists with a history of suicidality or mental illness would anticipate greater stigma from the public and self.MethodsThe study received ethical approval from the Commission for Medical Ethics of the Republic of Slovenia. Data from 83 participants who completed an online survey (February to May 2020) with informed consent were analyzed using path analysis. We tested a model predicting help-seeking self-stigma based on (i) personal experience of mental illness using anticipated self-stigma of mental illness as a mediating variable and (ii) history of suicidal behavior using anticipated public stigma of suicidal behavior as a mediating variable.ResultsPersonal experience of mental illness predicted anticipation of self-stigma of mental illness (β = 0.26). History of suicidality predicted anticipation of public stigma of suicidal behavior (β = 0.29). Anticipated self-stigma of mental illness proved to be a stronger predictor of help-seeking self-stigma (β = 0.40) than anticipated public stigma of suicidal behavior (β = 0.07).ConclusionsIt is important to intentionally support the mental health of suicide prevention professionals, as they are not immune to mental illness or various types of stigma. Because our sample was small and diverse, further research to better understand stigma concepts in this population is warranted.
Covariant Space-Time Line Elements in the Friedmann–Lemaitre–Robertson–Walker Geometry
Authors: Escors David , Kochan Grazyna 
Published: June 2022

Most quantum gravity theories quantize space-time on the order of Planck length (ℓp ). Some of these theories, such as loop quantum gravity (LQG), predict that this discreetness could be manifested through Lorentz invariance violations (LIV) over travelling particles at astronomical length distances. However, reports on LIV are controversial, and space discreetness could still be compatible with Lorentz invariance. Here, it is tested whether space quantization on the order of Planck length could still be compatible with Lorentz invariance through the application of a covariant geometric uncertainty principle (GeUP) as a constraint over geodesics in FRW geometries. Space-time line elements compatible with the uncertainty principle are calculated for a homogeneous, isotropic expanding Universe represented by the Friedmann–Lemaitre–Robertson–Walker solution to General Relativity (FLRW or FRW metric). A generic expression for the quadratic proper space-time line element is derived, proportional to Planck length-squared, and dependent on two contributions. The first is associated to the energy–time uncertainty, and the second depends on the Hubble function. The results are in agreement with space-time quantization on the expected length orders, according to quantum gravity theories, and within experimental constraints on putative LIV.
1950-2018 YILLARI ARASI MİLLETVEKİLİ GENEL SEÇİMLERİ SİYASAL EĞİLİM ANALİZİ: TRABZON İLİ ÖRNEĞİ
Authors: ŞAHİN Zeynep 
Published: June 2022

Çalışmada, çok partili hayatın ilk seçiminden günümüze kadar gerçekleşen on dokuz milletvekili genel seçim sonuçlarının hem Trabzon ili hem de Türkiye genelinde benzerliklerinin, farklılıklarının araştırılmasına ve ilin ülke genelindeki siyasal eğilim içindeki yerinin ortaya çıkarılmasına odaklanılmıştır. Milletvekili genel seçimlerine katılan siyasi partiler ile bloklar arasında meydana gelen oy geçişlerinin sağ-sol siyasal eksen özelinde incelenmesi suretiyle siyasal eğilimindeki düzenlilik ve değişimlerin saptanan bulgular neticesinde sunulması, böylece seçim sonuçlarının Trabzon ilinde kendine özgü ne gibi bir sonuç ortaya çıkardığının incelenmesi amaçlanmıştır. İçerik analizi yönteminin kullanıldığı bu çalışmada, genel seçim sonuçları Türkiye İstatistik Kurumu (TUİK) ve Yüksek Seçim Kurumu’nun (YSK) yayımladığı istatistiki verilerden yararlanılmak suretiyle sunulmuştur.
Çalışmanın sonucunda çok partili dönemin ilk seçiminde Trabzon ilinde, ülke genelindeki siyasal eğilimin tersi istikametinde, merkez solun (CHP) desteklendiği, sonraki süreçte siyasal eğilimin merkez sağa kaydığı; fakat Türkiye geneline kıyasla merkez solun ciddi oy kayıpları yaşamadığı görülmüştür. Bu durumun 1980 sonrasında tersine döndüğü, siyasal eğilimin yönü “merkez sağ ve sağ” partiler lehine işlediği, merkez sol ve sol partilere olan desteğin ciddi oranda gerilediği tespit edilmiştir. 2000’li yıllarda ise ilde siyasal eğilimin ibresi, merkez sağa talip, Ak Parti’yi gösterdiği; ülke geneline paralel olarak Ak Parti’nin oylarında inişli çıkışlı bir dalgalanma gerçekleşse de desteklenmeye devam edildiğine rastlanılmıştır. Ayrıca ilde MHP’nin ülke geneline kıyasla kimi seçimlerde öne çıktığı görülmüştür. Etnik Kürt partilerine olan eğilimin ülke geneline oranla yok denecek kadar düşük bir düzeyde seyrettiği tespit edilmiştir.
ZEYNEP YAŞAR’IN "HİNDİSTAN’IN DULLARI VE KADIN" ADLI KİTABI ÜZERİNE BİR İNCELEME
Authors: ARACI Erden 
Published: June 2022

Dünyada en fazla dulun yaşadığı ülke olan Hindistan’da, dulluk
meselesi toplumsal cinsiyet eşitsizliğinin de dışında kalarak adeta en
çok ötekileştirilen grup haline dönüşmüştür. Cinsiyet eşitsizliğinin
toplumun tüm kültürel normlarına sızdığı Hindistan’da toplumda
kadının yeri tartışması yaşanan diğer geleneksel/ataerkil ülkelere
nazaran, kadın olmanın verdiği eşitsizlik yükü yetmezmiş gibi dulluk
olgusu ile kadınlar adeta geleneksel dışlanmışlık kastına
sıkıştırılmıştır. Tarihsel olarak toplumun kültürel normlara bakışı
zaman içinde daha katlanabilir duruma gelmiş olsa da Hindistan’da
kadın olmak ve kadınların da yüz karası olarak görülen dulluk
günümüzde 46 milyon Hintli kadını dünyada en çok incelenebilecek
kadın çalışmaları laboratuvarı öznesi haline dönüştürmüştür. Sadece
konusuyla bile Zeynep Yaşar’ın Hindistan’ın Dulları Ve Kadın eseri,
kadın çalışmaları yazınına verdiği katkı ile çok önemli bir yere
oturuyor. Yine, Türk literatüründe yabancı ülkelerde vaka analizi
çalışan kadın çalışmalarının henüz yeni olduğu bir dönemde
kilometrelerce uzakta bir ülkede dulluk olgusunu toplumu ve
arkasındaki itici güçleri ile birlikte, karşılaştırmalı inceleyen bu eser
bize bilmediğimiz coğrafya, gelenek ve normlar üzerine ilgi çekici
bilgiler sunuyor.
INFLUENCE OF DEVASTIN ON THE INVASION OF MIXED STURGEON MONOGENETIC SUCKER DACTYLOGYRUS VASTATOR
Authors: Хорошайло Т.А. , Сердюченко И.В. , Козубов А.С. 
Published: June 2022

Проблема и цель. Целью исследований явилось теоретическое обоснование и практическая реализация способа обработки взрослых особей осетровых противопаразитарным препаратом Девастином, предназначенным для обработки поверхности тела и жабр рыб. Методология. Объект исследования: помеси 6-ти и 7-летнего возраста, полученные от ленского и русского осетра, выращенные в одном из рыбоводных хозяйств Краснодарского края. Обработку рыб проводили в осенний период с использованием раствора Девастина в дозе 2 г/л воды в лотке объемом 500 л с экспозицией 30 мин на 36 головах при температуре воды 20-22о С. Эффективность обработки оценивали по ихтиологическим показателям до и после обработки, а также общему состоянию, поведению рыб и поедаемости ими кормов, определяемыми на третий и седьмой день на всем обработанном поголовье. Результаты. Выявлено, что обработка рыб антипаразитарным препаратом дала положительный эффект. Экстенсивность инвазии сократилась на 76,6 %. Интенсивность инвазии составила от 3 до 8 паразитов на одной рыбе. Индекс обилия сократился с 43 до 4 экземпляров на одной особи (в 10,8 раз). Заключение. Предложенный способ обработки рыб имеет наибольшие перспективы использования для профилактической обработки прудовых рыб, что в итоге повышает рыбопродуктивность осетровых.
Problem and purpose. The aim of the research was the theoretical substantiation and practical implementation of the method of treating adult sturgeons with the antiparasitic drug Devastin, intended for treating the surface of the body and gills of fish. Methods. Object of study: crossbreeds of 6 and 7 years old, obtained from Lena and Russian sturgeon, grown in one of the fish farms of the Krasnodar Territory. Fish treatment was carried out in the autumn period using a Devastin solution at a dose of 2 g/l of water in a 500-l tray with an exposure of 30 minutes on 36 heads at a water temperature of 20–22°C. The effectiveness of the treatment was evaluated by ichthyologic indicators before and after treatment, as well as the general condition, behavior of the fish and their feed intake, determined on the third and seventh days for the entire treated population. Results. It was found that the treatment of fish with an antiparasitic drug had a positive effect. Extensiveness of invasion decreased by 76.6%. The intensity of invasion was from 3 to 8 parasites per fish. The abundance index decreased from 43 to 4 specimens per individual (by 10.8 times). Conclusion. The proposed method of processing fish has the greatest prospects for use for the preventive treatment of pond fish, which ultimately increases the fish productivity of sturgeons.
LABORATORY STUDIES OF THE OPTIMAL PARAMETERS OF THE LEVELING DEVICE OF THE UNIT FOR THE UTILIZATION OF THE NON-GRAIN PART OF THE CROP
Authors: Есенин М.А. , Богданчиков И.Ю. , Борычев С.Н. , Безносюк Р.В. , Бачурин А.Н. 
Published: June 2022

Проблема и цель. Целью проводимого исследования является получение зависимости ширины валка незерновой части урожая после разравнивания от параметров разравнивающего устройства. Методология. Для достижения поставленной цели в лабораторных условиях моделировали валок соломы озимой пшеницы. Смоделированный валок подвергался разравниванию разравнивающим устройством с различными параметрами угла при вершине, высоты установки и рабочей скорости агрегата. После разравнивания проводили измерение ширины и высоты поперечного профиля разравненного валка. Анализ полученных данных осуществляли при помощи программного обеспечения Microsoft Office Excel. Результаты. В ходе проведенных исследований были получены результаты ширины валка незерновой части урожая после взаимодействия с разравнивающим устройством с углом при вершине 90, 110, 130, 150 градусов, а также с высотой установки 0,2; 0,25; 0,3; 0,35; 0,4; 0,45 метра и рабочей скоростью движения 6, 8 и 10 км/ч. Выводы. Наибольшая ширина валка незерновой части урожая после разравнивания достигается при разравнивающем устройстве с углом при вершине 130 градусов. Высота установки разравнивающего устройства должна находиться в пределах 0,27-0,32 м, что соответствует перекрытию 40 % высоты исходного валка незерновой части урожая. При этом наиболее результативно разравнивающее устройство работало с рабочей скоростью 8 км/ч.
Problem and purpose. The purpose of the study is to obtain the dependence of the swath width of the nongrain part of the crop after leveling on the parameters of the leveling device. Methodology. To achieve this goal, a swath of winter wheat straw was modeled under laboratory conditions. The simulated swath was leveled by a leveling device with different parameters of the angle at the top, installation height and the operating speed of the unit. After leveling, the width and height of the cross profile of the leveled swath were measured. The data obtained were analyzed using the Microsoft Office Excel software. Results. In the course of the studies, the results of the roll width of the non-grain part of the crop were obtained after interaction with a leveling device with an angle at the top of 90, 110, 130, 150 degrees, as well as with an installation height of 0.2, 0.25, 0.3, 0.35 , 0.4, 0.45 meters and a working speed of 6, 8 and 10 km/h. Conclusions. The largest swath width of the non-grain part of the crop after leveling is achieved with a leveling device with an angle at the top of 130 degrees. The installation height of the leveling device should be in the range of 0.27 - 0.32 m, which corresponds to the overlap of 40% of the height of the original swath of the nongrain part of the crop. At the same time, the leveling device worked most efficiently at a working speed of 8 km/h.
Unjuk Kerja Kincir Air Sudu Lengkung Yang Bekerja Pada Saluran Horizontal
Authors: Boli Rahmad Hidayat , Makhsud Abdul , Mahmudin Mahmuddin 
Published: June 2022

Kincir air bentuk sudu Lengkung dengan diameter kincir 1,000 m, panjang sudu 0,25 m, dan lebar sudu 0,3 m. penelitian ini bertujuan untuk mengetahui daya dan efisiensi kincir air. Untuk menguji kincir air tersebut, maka dibuatkan model saluran terbuka dengan panjang saluran 12,25 m, lebar saluran 0,334 m, tinggi saluran 6,0 m, dan sudut kemiringan 450. Daya dan efisiensi kincir air dapat diketahui dengan memvariasikan debit aliran 0,050 m3/s sampai 0,032 m3/s pada beban 2 kg sampai 22 kg. Pengukuran debit aliran dengan metode mengisi ember dengan voleme ember 50 L. Untuk mengetahui debit aliran yang melalui saluran maka volume ember dibagi dengan waktu yang dibutuhkan untuk mengisi ember tersebut.
Modifikasi Mesin Motor Honda C70 100cc Menjadi 187cc Menggunakan Blok Kop Yamaha Jupiter
Authors: Kurniawan Mochamad Oky Tri , Rijanto Achmad , Hakim Luthfi 
Published: June 2022

Tujuan penelitian ini adalah untuk meningkatkan performa pada mesin pada daya motor dan torsi. Metode yang kami gunakan pada penelitian ini adalah metode eksperimental dan pada metode penelitian ini dilakukan dengan metode alat dynotest dan perhitungan menggunakan rumus dengan dua kondisi mesin motor yaitu kondisi mesin motor c70 standart dan mesin motor yang sudah dimodifikasi. Hasil pengujian ini menunjukkan bahwa daya dan torsi pada motor yang dimodifikasi lebih besar dari pada daya, torsi mesin motor standart. Daya rata-rata motor modifikasi naik menjadi 11,07 sedangkan daya pada motor mesin standart adalah 10,96 , dan untuk torsi motor standart 8,78 N.m sedangkan hasil torsi motor yang sudah dimodifikasi adalah 9,99 N.m.
Analisis Head Losses Pada Mesin Pompa Air Sawah
Authors: Rijanto Achmad , Rahayuningsih Suesthi 
Published: June 2022

Ketika fluida melalui pipa atau saluran terdapat pengurangan dari energi yang dialirkan searah dengan aliran fluida. Pengurangan energi ini mengakibatkan terjadinya kerugian tinggi (head losses). Penelitian ini bertujuan untuk mengetahui head losses pada mesin pompa air yang biasa digunakan di persawahan. Metode penelitian ini menggunakan penghitungan head losses pompa berdasarkan spesifikasi sebagai berikut; head dorong maksimal 32 m, head hisap maksimal 8 m, kapasitas aliran maksimal 1000 liter/menit, diameter pipa hisap 3 inci, diameter pipa dorong 3 inci, tegangan listrik 220 V, daya keluaran maksimal motor (bersih) 4,8 HP/3600 rpm dan daya keluaran maksimal motor (kotor) 5,5 HP/3600 rpm . Dari hasil penelitian diperoleh, bahwa head losses pompa air sawah 9,54 m, terdiri dari head losses pipa hisap sebesar 1,908 m dan head losses pipa dorong sebesar 7,632 m.