bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hyper–Kähler Manifolds of Generalized Kummer Type and the Kuga–Satake Correspondence
Authors: Varesco M. , Voisin C. 
Published: October 2022

AbstractWe first describe the construction of the Kuga–Satake variety associated to a (polarized) weight-two Hodge structure of hyper-Kähler type. We describe the classical cases where the Kuga–Satake correspondence between a hyper-Kähler manifold and its Kuga–Satake variety has been proved to be algebraic. We then turn to recent work of O’Grady and Markman which we combine to prove that the Kuga–Satake correspondence is algebraic for projective hyper-Kähler manifolds of generalized Kummer deformation type.
Selective effects of a brain tumor on the metric representation of the hand: a pre- versus post-surgery comparison
Authors: Mora Laura , Committeri Giorgia , Ciavarro Marco , Cocchini Gianna 
Published: October 2022

AbstractBody representation disorders are complex, varied, striking, and very disabling in most cases. Deficits of body representation have been described after lesions to multimodal and sensorimotor cortical areas. A few studies have reported the effects of tumors on the representation of the body, but little is known about the changes after tumor resection. Moreover, the impact of brain lesions on the hand size representation has been investigated in few clinical cases. Hands are of special importance, as no other body part has the ability for movement and interaction with the environment that the hands have, and we use them for a multitude of daily activities. Studies with clinical population can add further knowledge into the way hands are represented. Here, we report a single case study of a patient (AM) who was an expert bodybuilder and underwent a surgery to remove a glioblastoma in the left posterior prefrontal and precentral cortex at the level of the hand’s motor region. Pre- (20 days) and post- (4 months) surgery assessment did not show any motor or cognitive impairments. A hand localization task was used, before and after surgery (12 months), to measure possible changes of the metric representation of his right hand. Results showed a post-surgery modulation of the typically distorted hand representation, with an overall accuracy improvement, especially on width dimension. These findings support the direct involvement of sensorimotor areas in the implicit representation of the body size and its relevance on defining specific size representation dimensions.
Challenges in the diagnosis and management of immune-mediated necrotising myopathy (IMNM) in a patient on long-term statins
Authors: Khan Faris , Brady Stefen , Kuttikat Anoop 
Published: October 2022

AbstractImmune-mediated necrotising myopathy (IMNM) is a severe and poorly understood complication of statin use. Prompt management with immunosuppressive treatment is often needed to control the condition, which differs from the management of the more commonly recognised statin-induced myopathy. We present a case report and brief review of the literature regarding the pathogenesis, diagnosis, and management of anti-3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) positive IMNM (HMGCR IMNM). There are no randomised clinical trials, but several smaller studies and cases suggest a triple therapy of corticosteroids, IVIG, and a corticosteroid-sparing immunosuppressant appears efficacious in patients with IMNM and proximal weakness. The mechanism of statin-induced IMNM is uncertain, and this is further complicated by the reports of HMGCR IMNM in statin-naïve patients, including children. We present a case of biopsy-confirmed HMGCR IMNM in a woman taking daily statins for treatment of hypercholesterolaemia for 4 years. She presented with symptoms consistent with a urinary tract infection (UTI), including muscle weakness. She was treated as an isolated case of UTI. One month later, she presented again with worsening weakness in her shoulders and hips. Creatine kinase was elevated, and MRI showed increased signal with STIR sequences in both thighs. Anti-HMGCR was positive and leg biopsy-confirmed necrotising changes. Stopping her statin prescription and a short course of prednisolone did not improve her muscle weakness. Adding methotrexate resulted in eventual resolution of her symptoms. IMNM should be considered as a differential in any patient taking statins presenting with muscle weakness, and this case suggests that immunosuppressant therapy in addition to cessation of statins is effective at treating IMNM. Clinical trials are needed to further investigate the efficacy of different combinations of immunosuppressants.
Artificial intelligence, machine learning, and deep learning in rhinology: a systematic review
Authors: Bulfamante Antonio Mario , Ferella Francesco , Miller Austin Michael , Rosso Cecilia , Pipolo Carlotta , Fuccillo Emanuela , Felisati Giovanni , Saibene Alberto Maria 
Published: October 2022

Abstract
Purpose
This PRISMA-compliant systematic review aims to analyze the existing applications of artificial intelligence (AI), machine learning, and deep learning for rhinological purposes and compare works in terms of data pool size, AI systems, input and outputs, and model reliability.

Methods
MEDLINE, Embase, Web of Science, Cochrane Library, and ClinicalTrials.gov databases. Search criteria were designed to include all studies published until December 2021 presenting or employing AI for rhinological applications. We selected all original studies specifying AI models reliability. After duplicate removal, abstract and full-text selection, and quality assessment, we reviewed eligible articles for data pool size, AI tools used, input and outputs, and model reliability.

Results
Among 1378 unique citations, 39 studies were deemed eligible. Most studies (n = 29) were technical papers. Input included compiled data, verbal data, and 2D images, while outputs were in most cases dichotomous or selected among nominal classes. The most frequently employed AI tools were support vector machine for compiled data and convolutional neural network for 2D images. Model reliability was variable, but in most cases was reported to be between 80% and 100%.

Conclusions
AI has vast potential in rhinology, but an inherent lack of accessible code sources does not allow for sharing results and advancing research without reconstructing models from scratch. While data pools do not necessarily represent a problem for model construction, presently available tools appear limited in allowing employment of raw clinical data, thus demanding immense interpretive work prior to the analytic process.
Causal involvement of the left angular gyrus in higher functions as revealed by transcranial magnetic stimulation: a systematic review
Authors: Wagner Jennifer , Rusconi Elena 
Published: October 2022

AbstractTranscranial magnetic stimulation (TMS) is a non-invasive technique that can transiently interfere with local cortical functioning, thus enabling inferences of causal left AG involvement in higher functions from experimentation with healthy participants. Here, we examine 35 studies that measure behavioural outcomes soon after or during targeting TMS to the left AG, by design and as documented by individual magnetic resonance images, in healthy adult participants. The reviewed evidence suggests a specific causal involvement of the left AG in a wide range of tasks involving language, memory, number processing, visuospatial attention, body awareness and motor planning functions. These core findings are particularly valuable to inform theoretical models of the left AG role(s) in higher functions, due to the anatomical specificity afforded by the selected studies and the complementarity of TMS to different methods of investigation. In particular, the variety of the operations within and between functions in which the left AG appears to be causally involved poses a formidable challenge to any attempts to identify a single computational process subserved by the left AG (as opposed to just outlining a broad type of functional contribution) that could apply across thematic areas. We conclude by highlighting directions for improvement in future experimentation with TMS, in order to strengthen the available evidence, while taking into account the anatomical heterogeneity of this brain region.
Adaptation of the classical end-point ITS-PCR for the diagnosis of avian trichomonosis to a real-time PCR reveals Bonelli’s eagle as a new host for Trichomonas gypaetinii
Authors: Alejandro Mateo Sandra , Azami-Conesa Iris , Martín-Maldonado Bárbara , Pastor-Tiburón Natalia , Martín-Hernández Raquel , González-González Fernando , Gómez-Muñoz María Teresa 
Published: October 2022

AbstractAvian trichomonosis is a parasitic disease caused mainly byTrichomonas gallinaeand otherTrichomonasspecies. It can be asymptomatic, or it can produce a necrotic lesion in the upper digestive tract and spread to other organs, causing the death of the infected birds. In this study, we aimed to evaluate an adapted real-time PCR method for the diagnosis of different genotypes and species of avian oropharyngeal trichomonads. Fifty-six samples from the oropharynx of Bonelli’s eagles (Aquila fasciata) obtained between 2018 and 2019 were analyzed using the real-time PCR and the end-point PCR, both targeting trichomonads ITS, and the results were compared by a coefficient of agreement. All positive samples were sequenced. The analysis showed a higher percentage of detection of real-time PCR ITS compared with end-point PCR ITS (64.3 vs 55.4%), and good agreement value (Kappa = 0.816). Melting temperature value for resulting amplicons of real-time PCR for avian trichomonads was 83.45 ± 0.72 °C. Genotypes A, D, and III were found among the sequences. Moreover,Trichomonas gypaetinii, a common species in scavenger birds, is reported for the first time in Bonelli’s eagles.
Digital single-operator cholangioscopy to guide selective cannulation of complex biliary strictures
Authors: Kastelijn Janine B. , Didden Paul , Bogte Auke , Moons Leon M. G. , Vleggaar Frank P. 
Published: October 2022

Abstract
Background
Selective cannulation and stenting of complex, tight, and/or angulated biliary strictures under endoscopic retrograde cholangiopancreaticography (ERCP) can be challenging. Digital single-operator cholangioscopy (SOC) may facilitate guidewire advancement through the stricture with endoscopic visual guidance. We aimed to describe a case series on clinical outcomes of this technique for selective cannulation, when used after failed conventional ERCP attempts.

Methods
Consecutive patients who underwent therapeutic digital SOC for selective cannulation of biliary strictures after failed conventional ERCP were retrospectively included.

Results
Ten patients with a malignant (n = 6) or benign (n = 4) biliary stricture were included. Digital SOC-assisted selective guidewire insertion and stent placement across the biliary stricture were technically successful in five (50%) patients. Bilirubin levels improved in all patients with technical success. One (10%) patient developed a post-ERCP pancreatitis.

Conclusions
Technically successful cannulation of biliary strictures with digital SOC was achieved in half of patients in whom cannulation with conventional ERCP failed, sparing them more invasive interventions. Stricture opacification during the failed ERCP was seen in all technically successful SOCs.
DRE: density-based data selection with entropy for adversarial-robust deep learning models
Authors: Guo Yuejun , Hu Qiang , Cordy Maxime , Papadakis Michail , Le Traon Yves 
Published: October 2022

AbstractActive learning helps software developers reduce the labeling cost when building high-quality machine learning models. A core component of active learning is the acquisition function that determines which data should be selected to annotate.State-of-the-art (SOTA) acquisition functions focus on clean performance (e.g. accuracy) but disregard robustness (an important quality property), leading to fragile models with negligible robustness (less than 0.20%). In this paper, we first propose to integrate adversarial training into active learning (adversarial-robust active learning, ARAL) to produce robust models. Our empirical study on 11 acquisition functions and 15105 trained deep neural networks (DNNs) shows that ARAL can produce models with robustness ranging from 2.35% to 63.85%. Our study also reveals, however, that the acquisition functions that perform well on accuracy are worse than random sampling when it comes to robustness. Via examining the reasons behind this, we devise the density-based robust sampling with entropy (DRE) to target both clean performance and robustness. The core idea of DRE is to maintain a balance between selected data and the entire set based on the entropy density distribution. DRE outperforms SOTA functions in terms of robustness by up to 24.40%, while remaining competitive on accuracy. Additionally, the in-depth evaluation shows that DRE is applicable as a test selection metric for model retraining and stands out from all compared functions by up to 8.21% robustness.
Health-related quality of life in adolescents with idiopathic scoliosis: a cross-sectional study including healthy controls
Authors: Torén Suzanne , Diarbakerli Elias 
Published: October 2022

Abstract
Purpose
To describe health-related quality of life in adolescents with idiopathic scoliosis and controls.

Methods
This cross-sectional study analysed data from 307 individuals with idiopathic scoliosis and 80 controls without scoliosis (mean age 15.5 ± 2.1 and 14.0 ± 2.2 years, respectively). Health-related quality of life (HRQoL) was assessed using EuroQol 5-dimensions (EQ-5D) questionnaire, and the scoliosis specific Scoliosis Research Society-22r questionnaire (SRS-22r). HRQoL data in individuals with scoliosis were compared to controls, between treatment groups (untreated, ongoing brace, previously braced and surgically treated) and stratified according to curve size.

Results
Adolescents with idiopathic scoliosis had reduced HRQoL compared with controls, observed through lower SRS-22r subscore (respective means 4.16 and 4.68, p < 0.001) and lower EQ-5D index (respective means 0.92 and 0.95, p = 0.032).
No differences in SRS-22r subscore or EQ-5D index were detected when comparing different scoliosis treatment groups. Within the SRS-22r function domain the surgically treated group scored 4.40, significantly lower compared to the untreated (4.65) and ongoing brace groups (4.68, p = 0.005). The surgically treated and untreated group were more affected by pain, compared to the ongoing brace group (p = 0.01) with the surgically treated group scoring lowest. Non-surgically treated scoliosis individuals with larger curves (> 30 degrees) had a lower SRS-22r subscore (4.08) compared to those with smaller curves (4.31, p = 0.001).

Conclusion
Adolescents with idiopathic scoliosis had a reduced HRQoL compared to healthy controls. Minor differences were detected when comparing between idiopathic scoliosis treatment groups. Non-surgically treated scoliosis patients with larger curves had a lower HRQoL shown by lower SRS-22r values.
Change in upper limb function in people with multiple sclerosis treated with nabiximols: a quantitative kinematic pilot study
Authors: Pau Massimiliano , Porta Micaela , Spinicci Gabriella , Frau Jessica , Lorefice Lorena , Coghe Giancarlo , Cocco Eleonora 
Published: October 2022

Abstract

Objectives
Nabiximols represents an increasingly employed add-on treatment option for spasticity in people with multiple sclerosis (PwMS) who either were unresponsive or reported excessive adverse reactions to other therapies. While several studies performed in the last decade demonstrated its effectiveness, safety, and tolerability, few quantitative data are available on the impact on motor dysfunctions. In this open-label, not concurrently controlled study, we aimed to assess the impact of a 4-week treatment with nabiximols on upper limb functionality.

Methods
Thirteen PwMS (9 female, 4 male) with moderate-severe spasticity underwent a combination of clinical tests (i.e., Box and Block, BBT and Nine-Hole Peg test, 9HPT) and instrumental kinematic analysis of the “hand to mouth” (HTM) movement by means of optical motion capture system.

Results
After the treatment, improvements in gross and fine dexterity were found (BBT + 3 blocks/min, 9HPT − 2.9 s, p < 0.05 for both cases). The kinematic analysis indicated that HTM movement was faster (1.69 vs. 1.83 s, p = 0.05), smoother, and more stable. A significant reduction of the severity of spasticity, as indicated by the 0–10 numerical rating scale (4.2 vs. 6.3, p < 0.001), was also observed.

Conclusion
The findings from the present pilot study suggest that a 4-week treatment with nabiximols ameliorates the spasticity symptoms and the overall motor function of upper limb in PwMS with moderate-severe spasticity. The use of quantitative techniques for human movement analysis may provide valuable information about changes originated by the treatment in realistic upper limb motor tasks involved in activities of daily living.
A survey of continuous subgraph matching for dynamic graphs
Authors: Wang Xi , Zhang Qianzhen , Guo Deke , Zhao Xiang 
Published: October 2022

AbstractWith the rapid development of information technologies, multi-source heterogeneous data has become an open problem, and the data is usually modeled as graphs since the graph structure is able to encode complex relationships among entities. However, in practical applications, such as network security analysis and public opinion analysis over social networks, the structure and the content of graph data are constantly evolving. Therefore, the ability to continuously monitor and detect interesting patterns on massive and dynamic graphs in real-time is crucial for many applications. Recently, a large group of excellent research works has also emerged. Nevertheless, these studies focus on different updates of graphs and apply different subgraph matching algorithms; thus, it is desirable to review these works comprehensively and give a thorough overview. In this paper, we systematically investigate the existing continuous subgraph matching techniques from the aspects of key techniques, representative algorithms, and performance evaluation. Furthermore, the typical applications and challenges of continuous subgraph matching over dynamic graphs, as well as the future development trends, are summarized and prospected.
Prolonged Dexamethasone Exposure Enhances Zebrafish Lateral-Line Regeneration But Disrupts Mitochondrial Homeostasis and Hair Cell Function
Authors: Saettele Allison L. , Wong Hiu-tung C. , Kindt Katie S. , Warchol Mark E. , Sheets Lavinia 
Published: October 2022

AbstractThe synthetic glucocorticoid dexamethasone is commonly used to treat inner ear disorders. Previous work in larval zebrafish has shown that dexamethasone treatment enhances hair cell regeneration, yet dexamethasone has also been shown to inhibit regeneration of peripheral nerves after lesion. We therefore used the zebrafish model to determine the impact of dexamethasone treatment on lateral-line hair cells and primary afferents. To explore dexamethasone in the context of regeneration, we used copper sulfate (CuSO4) to induce hair cell loss and retraction of nerve terminals, and then allowed animals to recover in dexamethasone for 48 h. Consistent with previous work, we observed significantly more regenerated hair cells in dexamethasone-treated larvae. Importantly, we found that the afferent processes beneath neuromasts also regenerated in the presence of dexamethasone and formed an appropriate number of synapses, indicating that innervation of hair cells was not inhibited by dexamethasone. In addition to regeneration, we also explored the effects of prolonged dexamethasone exposure on lateral-line homeostasis and function. Following dexamethasone treatment, we observed hyperpolarized mitochondrial membrane potentials (ΔΨm) in neuromast hair cells and supporting cells. Hair cells exposed to dexamethasone were also more vulnerable to neomycin-induced cell death. In response to a fluid-jet delivered saturating stimulus, calcium influx through hair cell mechanotransduction channels was significantly reduced, yet presynaptic calcium influx was unchanged. Cumulatively, these observations indicate that dexamethasone enhances hair cell regeneration in lateral-line neuromasts, yet also disrupts mitochondrial homeostasis, making hair cells more vulnerable to ototoxic insults and possibly impacting hair cell function.
New separation protocol reveals spray painting as a neglected source of microplastics in soils
Authors: Xu Yaqi , Rillig Matthias C. , Waldman Walter R. 
Published: October 2022

AbstractMicroplastics are recently discovered contaminants, yet knowledge on their sources and analysis is limited. For instance, paint microplastics are poorly known because soil separation protocols using flotation solutions cannot separate paint microplastics due to the higher density of paint microplastic versus common microplastics. Here, we designed a new two-step density separation protocol for paint microplastics, allowing paint microplastics to be separated from the soil without digestion. Paint particles were separated from soil samples collected around the graffiti wall at the Mauerpark, Berlin, then quantified according to their shape and color characteristic. The presence of polymers as binders in the paint particles was verified by Fourier transform infrared spectroscopy. Results show concentrations from 1.1 × 105 to 2.9 × 105 microplastics per Kg of dry soil, representing the highest microplastic concentration ever reported in the literature. Particle concentrations decreased and the median size increased with soil depth. Our results provide first evidence that spray painting, a technique with a wide range of applications from industry to art, leaves a legacy of environmental microplastic in soils that has so far gone unnoticed.
Understanding the influence of indigenous values on change in the dairy industry
Authors: Knook Jorie , Wreford Anita , Gow Hamish , Hemi Murray 
Published: October 2022

AbstractCommunities, scientists, policy-makers and industries are requiring farmers to address environmental and wellbeing challenges in their on-farm management, transitioning away from a productivity dominated focus towards a multi-faceted system focus that includes environmental and social values. This paper analyses how Miraka Ltd., an Aotearoa-New Zealand indigenous owned and operated milk company, has taken on the role of institutional entrepreneur to enable and support change towards a multi-faceted system amongst its supply farmers. Observations and interviews were carried out to: (i) identify farmers’ changes in practices, beliefs and values over the last ten years; and (ii) identify how Miraka functions as an indigenous entrepreneur in the agricultural sector. Findings show that interviewees were initially guided by business and family-oriented values, beliefs and practices, but in response to the institutional entrepreneurship by Miraka, approximately half of the interviewees changed these values, beliefs and practices, by internalising people and environmental values. The main strategies employed by Miraka were mobilisation of material resources such as incentives and awards, creation of a rationale addressing environmental and social concerns in the dairy sector, and proactive connection with new actors. The research shows an indigenous owned small-medium enterprise can make changes in values, beliefs and practices amongst its supply farmers, but requires a stronger shared base of values to contribute to a wider economic change. The discussion connects these findings to wider literature on diverse economies and indigenous entrepreneurship to identify to what extent an indigenous small-medium enterprise can contribute to a system change.