bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hangover-Related Internet Searches Before and During the COVID-19 Pandemic in England: Observational Study
Authors: Robinson Eric , Jones Andrew 
Published: October 2022

Background
It is unclear whether heavy alcohol use and associated hangover symptoms changed as a result of the COVID-19 pandemic. Due to a lack of available accurate and nonretrospective self-reported data, it is difficult to directly assess hangover symptoms during the COVID-19 pandemic.

Objective
This study aimed to examine whether alcohol-induced hangover-related internet searches (eg, “how to cure a hangover?”) increased, decreased, or remained the same in England before versus during the COVID-19 pandemic (2020-2021) and during periods of national lockdown. Secondary aims were to examine if hangover-related internet searches in England differed compared to a country that did not impose similar COVID-19 lockdown restrictions.

Methods
Using historical data from Google Trends for England, we compared the relative search volume (RSV) of hangover-related searches in the years before (2016-2019) versus during the COVID-19 pandemic (2020-2021), as well as in periods of national lockdown versus the same periods in 2016-2019. We also compared the RSV of hangover-related searches during the same time frames in a European country that did not introduce national COVID-19 lockdowns at the beginning of the pandemic (Sweden). Hangover-related search terms were identified through consultation with a panel of alcohol researchers and a sample from the general public. Statistical analyses were preregistered prior to data collection.

Results
There was no overall significant difference in the RSV of hangover-related terms in England during 2016-2019 versus 2020-2021 (P=.10; robust d=0.02, 95% CI 0.00-0.03). However, during national lockdowns, searches for hangover-related terms were lower, particularly during the first national lockdown in England (P<.001; d=.19, 95% CI 0.16-0.24; a 44% relative decrease). In a comparison country that did not introduce a national lockdown in the early stages of the pandemic (Sweden), there was no significant decrease in hangover-related searches during the same time period (P=.06). However, across both England and Sweden, during later periods of COVID-19 restrictions in 2020 and 2021, the RSV of hangover-related terms was lower than that in the same periods during 2016-2019. Exploratory analyses revealed that national monthly variation in alcohol sales both before and during the COVID-19 pandemic were positively correlated with the frequency of hangover-related searches, suggesting that changes in hangover-related searches may act as a proxy for changes in alcohol consumption.

Conclusions
Hangover-related internet searches did not differ before versus during the COVID-19 pandemic in England but did reduce during periods of national lockdown. Further research is required to confirm how changes in hangover-related search volume relate to heavy episodic alcohol use.

Trial Registration
Open Science Framework 2Y86E; https://osf.io/2Y86E
Exploring Stakeholder Requirements to Enable the Research and Development of Artificial Intelligence Algorithms in a Hospital-Based Generic Infrastructure: Protocol for a Multistep Mixed Methods Study
Authors: Weinert Lina , Klass Maximilian , Schneider Gerd , Heinze Oliver 
Published: October 2022

Background
In recent years, research and developments in advancing artificial intelligence (AI) in health care and medicine have increased. High expectations surround the use of AI technologies, such as improvements for diagnosis and increases in the quality of care with reductions in health care costs. The successful development and testing of new AI algorithms require large amounts of high-quality data. Academic hospitals could provide the data needed for AI development, but granting legal, controlled, and regulated access to these data for developers and researchers is difficult. Therefore, the German Federal Ministry of Health supports the Protected Artificial Intelligence Innovation Environment for Patient-Oriented Digital Health Solutions for Developing, Testing, and Evidence-Based Evaluation of Clinical Value (pAItient) project, aiming to install the AI Innovation Environment at the Heidelberg University Hospital in Germany. The AI Innovation Environment was designed as a proof-of-concept extension of the already existing Medical Data Integration Center. It will establish a process to support every step of developing and testing AI-based technologies.

Objective
The first part of the pAItient project, as presented in this research protocol, aims to explore stakeholders’ requirements for developing AI in partnership with an academic hospital and granting AI experts access to anonymized personal health data.

Methods
We planned a multistep mixed methods approach. In the first step, researchers and employees from stakeholder organizations were invited to participate in semistructured interviews. In the following step, questionnaires were developed based on the participants’ answers and distributed among the stakeholders’ organizations to quantify qualitative findings and discover important aspects that were not mentioned by the interviewees. The questionnaires will be analyzed descriptively. In addition, patients and physicians were interviewed as well. No survey questionnaires were developed for this second group of participants. The study was approved by the Ethics Committee of the Heidelberg University Hospital (approval number: S-241/2021).

Results
Data collection concluded in summer 2022. Data analysis is planned to start in fall 2022. We plan to publish the results in winter 2022 to 2023.

Conclusions
The results of our study will help in shaping the AI Innovation Environment at our academic hospital according to stakeholder requirements. With this approach, in turn, we aim to shape an AI environment that is effective and is deemed acceptable by all parties.

International Registered Report Identifier (IRRID)
DERR1-10.2196/42208
Сарт-калмаки Пржевальского уезда Семиреченской области в начале XX в.
Authors:   Al-Farabi Kazakh National University (71, Al-Farabi Ave., 050040 Almaty, Republic of Kazakhstan), Miymanbaeva Fialka N. , Abdiraiymova Ardak S. , Aitkazina Mira M. ,   Academy of Logistics and Transport (97, Shevchenko St., 050012 Almaty, Republic of Kazakhstan)
Published: October 2022

Introduction. Economic conditions to have experienced by the Issyk-Kul Sart Kalmyks of Semirechenskaya Oblast in the early 20th century remain uninvestigated in historical literature, which makes the study relevant enough. Goals. The work aims to consider the traditional Sart Kalmyk system of farming, define its type, and analyze the transition to settled life. Materials and methods. The study employs both general scientific and specific historical research methods, including that of statistical analysis. The work examines materials from Russia’s central archives, as well as statistical survey data on economic and land use practices of the Kyrgyz — including households of Sart Kalmyks — and Russian old-timers collected in Przhevalsky Uyezd (Semirechenskaya Oblast) under the guidance of P. P. Rumyantsev in 1913. Analysis of statistical materials yields a reconstruction of the Sart Kalmyk economy in the early 20th century and determines its type. Results. The Sart Kalmyks to have inhabited several localities around Karakol in Issyk-Kul (Przhevalsky) Uyezd were engaged in livestock breeding and, in part, crop farming, i.e. were following their traditional economic practices. Conclusions. However, by the beginning of the 20th century the Sart Kalmyks no longer possessed sufficient pastures and livestock to specialize in breeding only, and were forced to tackle arable farming too, though the latter played no crucial role in their economy remaining an auxiliary sector. The lack of arable land and hayfields forced the Sart Kalmyks to engage in additional occupational activities. So, the population was characterized by a semi-sedentary type of farming, i.e. the period witnessed a change in the Sart Kalmyks’ economic system proper and respective conditions at large.
Food comes in bites: mammalian dietary space in terms of food items, nutrition and energy
Authors: Lintulaakso Kari , Tatti Nikolaj , Žliobaitė Indrė 
Published: October 2022

The accepted ORIGINAL ARTICLE is published in Mammalian
Biology:

https://doi.org/10.1007/s42991-022-00323-6

Lintulaakso, K., Tatti, N. and Žliobaitė, I., 2022. Quantifying
mammalian diets. Mammalian Biology, pp.1-15.
This preprint differs from the accepted version by leaving out the
energy contents of the mammalian diets.

Below is the abstract from the accepted manuscript:

We propose a quantitative approach for categorising mammalian diets
based on the taxonomy of food items and parts consumed (the form of
food). Our analysis covers 82% of the mammalian species alive today.
The diet information comes from different data sources—textbooks,
datasets and peer-reviewed literature and includes a transformation of
narrative quantitative data into qualitative data. We link a database on
nutrient composition of diet items of the quantitative diet data and
analyse the distribution of macronutrients of diets across taxonomic
groups and map them to the dental morphology of the eaters. The results
show associations between dental complexity and the concentrations of
some nutrients. Our analysis highlights omnivory as a multi-faceted
concept—there are many kinds of omnivores within the dietary space we
report. The developed dataset and the proposed approach relating the
chemical composition of diets offers a basis for future comparative
studies of living and fossil mammals. With this study, we make the
accompanying large-scale dietary data publicly available online
(https://www.mammalbase.net).
Congenital cytomegalovirus infection: features of the clinical course and catamnesis according to own observations
Authors: Antsiferova E. V. , Taranushenko T. E. , Geninova D. G. , Karpova L. N. , Filippova L. A. , Karaganova K. I. , Karpova L. S. 
Published: October 2022

Congenital cytomegalovirus infection is the most common congenital infection, occurs in 0.6-5% of newborns worldwide, and is considered the leading non-genetic cause of sensorineural hearing loss in children. Most newborns with a manifest form of the disease develop psychomotor and cognitive disorders, and about half of them develop visual impairment.The purpose of publication: to present a clinical case of severe congenital cytomegalovirus infection in the manifest period with multisystem manifestations (hemorrhagic syndrome, encephalitis, myocarditis, hepatitis, splenomegaly) and follow-up data at the age of 1 year.Conclusion. this clinical example demonstrates diagnostic and therapeutic difficulties in the acute period of the disease and a significant list of diseases resulting from infection. Based on the information presented, the importance and necessity of close attention to the results of a serological study of pregnant women during the entire gestation period with an assessment of the antibody titer to cytomegalovirus infection in dynamics are updated. Specific antiviral therapy, prescribed on the basis of a life-threatening course of a severe manifest form of the disease, made it possible to achieve positive dynamics in the acute period, eradicate the virus and prevent severe outcomes, including death.
Clinic and diagnosis of encephalopathy of critical conditions in children with infectious diseases
Authors: Egorova E. S. , Klimkin A. V. , Vilnits A. A. , Skripchenko N. V. , Voitenkov V. B. , Vasilyeva Yu. P. , Bedova M. A. 
Published: October 2022

Purpose: to assess the functional state of the brain in critically ill encephalopathy in children with infectious diseases.Materials and methods: 75 patients aged from 1 month to 17 years 11 months with infectious diseases, who were in the intensive care unit of the clinic, were examined, divided into two groups: the main group and the comparison group. Exclusion criteria: patients with cerebral palsy, organic lesions of the central nervous system, neuroinfections and epilepsy. Conducted daily clinical and neurological examination; study of the level of neurospecific proteins (NSE, protein S100) in blood serum; electroencephalography; study of evoked potentials of various modalities; ultrasound examination of the optic nerves, neuroimaging.Results: All patients had general infectious manifestations, the development of sepsis syndrome, cerebral systemic disorders with impaired consciousness, as well as convulsive syndrome. In the acute period of the disease in the main group, NSE values in 87.5% of children were within the upper limit of normal, S100 protein levels were many times higher than those in the comparison group. In dynamics, all patients showed an increase in the level of NSE, which correlated with persistent neurological symptoms in the form of irritability, weakness, and cognitive decline. In the comparison group, an increase in NSE occurred in 53% of children, an increase in S100 - in 83%. By the time of discharge, 47% of patients had an increase NSE and S100 protein. Visual evoked potentials in 84% of the children of the main group in the acute period, had a decrease the amplitude of the N2-P2 cortical response was revealed without significant dynamics in the future, which was accompanied by pronounced clinical manifestations, which made it possible to substantiate the expediency of dispensary observation of children who underwent a critical condition against the background of severe infectious pathology.Conclusion: in infectious diseases in children that are not accompanied by inflammatory processes in the nervous system, but proceed with the development of a critical condition, there is a neuropsychiatric deficit in the outcomes, which necessitates follow-up follow-up of such patients in the future.
Clinical and etiological characteristics of pneumonia in children with a poor outcome of infectious diseases
Authors: Kozyrev E. A. , Babachenko I. V. , Karev V. E. , Pimenov D. A. , Sharipova E. V. , Orlova E. D. , Tian N. S. 
Published: October 2022

Purpose: to study the clinical and etiological features of pneumonia in children with a poor outcome of infectious diseases.Materials and methods. The retrospective analysis of clinical, anamnestic, laboratory, instrumental data of 46 children who died from infectious diseases during the period from December 2009 to November 2019 was carried out, of which 26 patients had pneumonia at autopsy. The etiology of pneumonia was determined in vivo and postmortem using cultural, molecular genetic, serological methods and immunohistocytochemical examination of lung tissue. Pneumonia was classified into primary and secondary.Results. In patients with pneumonia in the structure of generalized infections (n=26) secondary forms prevailed (septic – 14 cases, ventilator-associated (VAP) – 5, aspiration – 2); primary pneumonia was detected in 5 children. Clinical polymorphism and frequent absence of typical symptoms of pneumonia (cough, shortness of breath, auscultatory and percussion changes) were shown, that led to intravital underdiagnosis of pneumonia in 31% of patients. The probable etiology of pneumonia was detected in vivo and postmortem in 58% and 98% of cases respectively. S. pneumoniae (40%) and H. influenzae type b (40%) were main pathogens in primary pneumonia, N. meningitidis (36%) and S. pneumoniae (29%) – in septic pneumonia, commensals of naso- and oropharynx (S. salivarius) – in aspiration pneumonia, nosocomial bacteria (S. aureus and coagulase-negative staphylococci) – in VAP. In children with HIV infection, pneumonia was associated with opportunistic pathogens (P. jirovecii, C. neoformans). In 87% of cases polymicrobial associations were found in lower airways, that makes it difficult to identify the main causative agent of pneumonia.Conclusions. Most of symptoms of pediatric pneumonia in the structure of generalized infections are nonspecific. Post-mortem study improves the etiological verification of pneumonia and allow to suggest the most pathogenetically and thanatogenetically significant pathogen.
Aspects of cytomegalovirus reactivation in critically ill patients
Authors: Gorbachev V. V. , Dmitrachenko T. I. , Semenov V. M. , Egorov S. K. 
Published: October 2022

Cytomegalovirus plays an essential role in human pathology. Primary infection usually occurs in childhood and subsequently, a lifelong latency is formed which the virus replicates by evading the immune response. In recent years, more and more researchers have concluded that cytomegalovirus reactivation may occur in critically ill patients. Despite the available evidence, data on reactivation in this group of patients are limited by the relatively small sample size, the variety of patient groups studied, the differences in study methodology, and the variability in reported results, which excludes the possibility of summarizing the results.This study aimed to determine the frequency of reactivation of cytomegalovirus infection in critically ill patients and to identify its main clinical features.Materials and methods. The study included 118 critically ill patients with severe bacterial and viral-bacterial infections accompanied by multiple organ dysfunction. Cytomegalovirus reactivation was determined by the detection of DNA in combination with the presence of IgG.Results. Reactivation was detected in 36.4% of cases. Frequency and terms of reactivation in blood and sputum as well as trends of viral load changes in dynamics were shown. The main clinical features of reactivation in different pathologies (sepsis of bacterial etiology, COVID-19, non-septic critical patients) were noted. HCMV DNA was more frequently detected in the blood of septic patients (44.8%) compared with COVID-19 (13.0%, p<0.05) and non-septic critically ill patients (19.2%, p<0.05). COVID-19 was characterized not only by lower detection of HCMV DNA in the blood but also by the lowest viral loads (p<0.05). HCMV DNA in sputum was detected comparably frequently in sepsis (38.1%) and COVID-19 (33.3%), but the highest viral loads were characteristic of patients with sepsis (p<0.05).
The role of gene polymorphism of some immune response molecules in the development of acute virus-induced bronchiolitis
Authors: Bochkareva L. S. , Miromanova N. A. , Miromanov A. M. 
Published: October 2022

The aim of research: To investigate the genetic polymorphism of immune response molecules (TNFα-308G> A (rs1800629), IL4-589C>T (rs2243250), IL10-592C> A (rs1800872), IL10-819C> T (rs1800871), IL10-1082G>A (rs1800896), IL-17A-197G> A (rs2275913), IL- 17F-161His> Arg (rs763780), TLR-2-753Arg>Gln (rs5743708), TLR-6-249Ser>Pro (rs5743810) and assess their prognostic value in the development of acute virus-induced bronchiolitis.Materials and methods. The study included children of the first year of life, whose average age was 4.2 ± 3.7 months. The main group consisted of 106 patients with moderate and severe acute viral bronchiolitis, more often associated with respiratory syncytial virus (56.6%). The control group consisted of 100 healthy children of the same age who had no signs of acute respiratory infection at the time of examination and did not receive passive immunoprophylaxis of respiratory syncytial infection. Genotyping was performed using the polymerase chain reaction method. The analysis of the results included the compliance with the Hardy-Weinberg law, the χ 2 test, the relative chance, and its 95% confidence interval. To assess the distribution of the claimed gene polymorphisms and their alleles, we used the general (χ2 test, df =2) and multiplicative (χ2 test, df =1) inheritance models.Results. It was revealed that the risk of developing acute viral bronchiolitis is increased compared to the healthy population in carriers of the following genotypes: CC, ST gene IL10-819C> T (rs1800871), GG, AA gene IL-17A-197G> A (rs2275913), HisHis gene IL-17F-161His> Arg (rs763780), SerSer, SerPro gene TLR-6-249Ser> Pro (rs5743810), GG gene TNF-α-308G>A (rs1800629). The TT genotype of the IL10-819C>T (rs1800871) gene is associated with a high risk of developing bacterial complications (pneumonia) in viral bronchiolitis. Carriers of genotypes AA, CC of the IL10-592C> A (rs1800872) gene have an increased likelihood of a severe course of viral bronchiolitis.Conclusion. Genetic analysis of gene polymorphism IL10-592C> A (rs1800872), IL10-819C> T (rs1800871), IL-17A-197G> A (rs2275913), IL-17F-161His> Arg (rs763780), TLR-6-249Ser> Pro (rs5743810), TNF-α-308 G>A (rs1800629) can be used as a personalized developmental criterion acute virus-induced bronchiolitis in children, determining the severity of its course and the likelihood of complications.
Pengembangan Landmark dan Agrowisata Cokelat (Studi Kasus Desa Banjarharjo, Kecamatan Kalibawang)
Authors: Krismiyanto, MT. Ir. Yoseph Dwikora 
Published: October 2022

Kuliah Kerja Nyata (KKN) is an action used by the student to do community services. Community services have a goal to increase the potency that is owned by a region. Through the action of KKN 79, Group 23 has a program to develop the potency of Desa Banjarharjo, Kecamatan Kalibawang, Kabupaten Kulon Progo. Desa Banjarharjo is a village that has a high potency of chocolate, but that potential is not fully utilized. Because of that, Group 23 research to develop the village potential. The research is done with secondary data collected from the internet. This is due to the limited conditions caused by the pandemic so that direct data collection is not possible. Based on the data that have been collected, the result is a program to make a landmark of the village for the village’s identity and the development of chocolate agrotourism. The program is supported by the marketing guide, legality guide, taxation guide, development of the chocolate product, and village’s branding that can be found in KKN Buku Saku.
An Ecological-Oriented Policy Development Framework as An Alternative to Contesting Land-Oriented and Maritime-Oriented Paradigms
Authors: Rahmawati Deti 
Published: October 2022

Two diverging geography-oriented Policy development paradigms have been prevailing within the discourse of Indonesian context, namely land and maritime-oriented paradigms. The two paradigms often emerge in ideological discourses that predispose national identity. Throughout the Indonesia’s history, discourses on development paradigms seems to alternate between two paradigms. However, since 2014, maritime paradigm has taken a dominant role in the Indonesian discourses.This paper propose empirical data associated with the environmental, economic and social conditions of Segara Anakan, Central of Java, we show how the land paradigm has resulted in undesirable consequences. Segara Anakan is a coastal region in which various communities have for decades developed economic activities. Major environmental damages in the region have been reported and social conflicts have occurred unresolved. Instead of choosing between land and maritime paradigms, in this paper we propose a more ecological-oriented development framework that is based on actor-network theory. we emphasis key measures: registering relevant heterogeneous entities, including human actors, social groups, small islands, straits, ocean inhabitants, etc; consultations that involve various spoke-persons. We argue in the paper that both land and maritime paradigms are too macro in their scope to tackle heterogeneities and complexities at the regional scopes.