bluuebunny/crossref_metadata_2025_split huggingface dataset:
Characterizing incidental mass lesions in abdominal dual-energy CT compared to conventional contrast-enhanced CT
Authors: Xu Jack Junchi , Ulriksen Peter Sommer , Bjerrum Camilla Wium , Achiam Michael Patrick , Resch Timothy Andrew , Lönn Lars , Lindskov Hansen Kristoffer 
Published: August 2022

Background Incidental findings are common in abdominal computed tomography (CT) and often warrant further investigations with economic implications as well as implications for patients. Purpose To evaluate the potential of dual-energy CT (DECT) in the identification and/or characterization of abdominal incidental mass lesions compared to conventional contrast-enhanced CT Material and Methods This retrospective study from a major tertiary hospital included 96 patients, who underwent contrast-enhanced abdominal DECT. Incidental lesions in adrenals, kidneys, liver, and pancreas were evaluated by two board-certified abdominal radiologists. Observer 1 only had access to standard CT reconstructions, while observer 2 had access to standard CT as well as DECT reconstructions. Disagreements were resolved by consensus review and used as a reference for observers using McNemar's test Results Observers 1 and 2 identified a total of 40 and 34 findings, respectively. Furthermore, observer 1 registered 13 lesions requiring follow-up, of which seven (two renal and five adrenal lesions) were resolved following consensus review using DECT ( P = 0.008). The inter-observer agreement was near perfect (﻿κ = 0.82). Conclusion DECT has the potential to improve the immediate characterization of incidental findings when compared to conventional CT for abdominal imaging.
Discrete modeling and calculation of traction return-current network for 400 km/h high-speed railway
Authors: Yang Shiwu , Liu Chang 
Published: August 2022

The planned 400 km/h high-speed train capable of cross-border intermodal transportation will inevitably cause a greater return-current and bring more challenges to signaling infrastructure and integrated grounding while achieving stronger traction. Based on the existing AC autotransformer power supply mode, this paper proposes a discrete modeling and calculation method of the traction return-current network concerning impedance equivalent, realizing the simulation and quantitative analysis of the return-current distribution of multiple current-carrying conductors in the block section and station yard under the double-track condition. Then, the dynamic distribution is analyzed comprehensively considering traction power supply, signaling, and integrated grounding systems. Also, the method is verified with field test data. Finally, the simulation of the return-current proportion of multiple conductors is carried out under the dynamic operating conditions of high speed, and the distribution characteristics are compared and analyzed under different ballast resistances. In the most unfavorable case, the maximum return-current in the rails, grounding wire, and protective wire can reach 1046 A, 180 A, and 126 A, respectively. This work helps evaluate the electromagnetic compatibility between signaling and strong currents in engineering practice, further optimize the capacity configuration of equipment along the railway lines, and improve the signaling immunity design.
A Systematic Review: Study on Challenges Faced by Dental Interns in the Workforce: Suggestions for Pacific Nations
Authors: Nair Richard D. , Gohil Dilan A. , Reddy K. Venkata Raman , Mohammadnezhad Masoud 
Published: August 2022

Aim To identify challenges faced by dental interns in the workforce and to suggest Pacific Island Countries (PIC) on further research in this area. Materials and Methods A comprehensive search of Medline, Embase, Scopus and ProQuest databases was conducted using relevant keywords. All studies, published from 1st January 2000 to 31st January 2021, were taken into consideration. Removal of duplicates and screening the full-text articles using eligibility criteria were used to finalise the number of articles. The significant findings and conclusions were extracted and grouped under themes. Results A total of 16 studies met the inclusion criteria, involving dental interns, medical interns, postgraduate and undergraduate. Five themes were identified as the main challenges faced by dental interns in the workplace including workplace bullying, handling medical emergencies, community placement, lack of interdisciplinary approach and poor record keeping. Conclusion There is a need for PIC to conduct research and surveys, to identify the challenges its dental interns may be facing. This will create an ideal foundation from which strategies and initiatives can be implemented and enforced in the dental internship programme. Ensuring that oral health services are delivered efficiently and oral status of the Pacific is not compromised.
Posttraumatic Growth and its Correlates Among Parents of Children With Cleft Lip and/or Palate
Authors: He Miao , Shi Bing , Zheng Qian , Gong Caixia , Huang Hanyao 
Published: August 2022

This study examined the posttraumatic growth (PTG) about parents of children with cleft lip and/or palate (CL/P) and the correlates of PTG. A cross-sectional study. Parents (N = 388) of children with isolated CL/P (ages 3 months-18 years) who had at least one cleft surgery within an oral and maxillofacial surgery department of a university-affiliated tertiary hospital in a provincial capital in southwest China. Demographic information questionnaire, The Posttraumatic Growth Inventory, Simplified Coping Style Questionnaire, and Social Support Rating Scale were used for data collection. Parents’ mean PTG score was in the moderate range (M = 65.7, SD = 13.73). PTG differed regarding the participants’ sex, ethnicity, and educational background. Pearson's correlation analysis revealed that positive coping ( r = 0.43, P < .01), negative coping ( r = 0.13, P < .01), and social support ( r = 0.26, P < .01) were positively correlated with PTG. Multiple regression model showed that 20.6% ( P < .001) of the variance in PTG was explained by higher positive coping (β = 0.35, P < .001), greater social support (β = 0.13, P = .01), and for cleft lip compared to cleft palate (β = −0.14, P ≤ .01), with no variance difference for cleft lip and palate. Parents of children with CL/P had moderate PTG. Potentially modifiable correlates of PTG suggest interventions to enhance parental positive coping and social support may increase PTG. Further studies are needed to confirm the PTG level and its affecting factors of parents of children with CL/P.
Expert recommendations for the management of diabetic macular edema with intravitreal dexamethasone implant: A Turkish Delphi study
Authors: Batıoğlu Figen , Yanık Özge , Saatçi Ali Osman , Eldem Bora , Akkın Cezmi , Afrashi Filiz , Özdemir Hakan , Menteş Jale , Güngör Kıvanç , Karabaş Levent , Karaçorlu Murat , Demircan Nihal , Koçak Nilüfer , Kır Nur , Ünlü Nurten , Avcı Remzi , Arvas Sema , Dündar Sema Oruç , Kadayıfçılar Sibel , Kaynak Süleyman , Özdek Şengül , Ovalı Tunç 
Published: August 2022

Purpose To provide consensus on the clinical use of intravitreal dexamethasone (DEX) implant for the treatment of diabetic macular edema (DME) in Turkey. Methods A panel of 22 retina experts prepared 77 statements of recommendation, and 80 retinal specialists practicing in Turkey were chosen to vote either in support or against each one. A Delphi-based method was used through which the ophthalmologists were able to view all of the results anonymously after two rounds and modify their subsequent answers. The survey was conducted via a mini website, and statements without consensus were resent to the specialists with the latest vote results a week later. Results A total of 72 ophthalmologists answered the first and second round questions. After the first stage, consensus was achieved on 55 of the statements, leaving 22 without agreement. After the second stage, consensus was reached on 11 of the remaining statements. Strong consensus was achieved on statements regarding the etiopathogenesis of DME and the first-line indications and safety of the DEX implant procedure. The panel recommended the use of DEX implant for patients with an arterial thromboembolic event in the last three months and also agreed that pro re nata DEX implant treatment not only provides better outcomes for DME patients but also reduces the treatment burden for those who could not receive an adequate number of anti-vascular endothelial growth factor (VEGF) injections. Conclusion This study provides clinical consensus and recommendations about the use of DEX implant in the clinical practice of DME management in Turkey.
Awareness regarding generic and ethical medicines, and Jan Aushadhi Kendra: A survey-based study
Authors: Sareen Ashutosh , Singh Gurvinder , Wadhwa Sheetu , Khurana Navneet , Kumar Rajesh 
Published: August 2022

Background Increased healthcare charges remain a prime subject worldwide, especially in underdeveloped and developing countries like India, where economic conditions are on the lower side. To control this, the Government of India (GoI) launched Jan Aushadhi scheme in April 2008 for providing low-cost generic medicines, however, the scheme has not been able to reach an extent. Moreover, the patients rely on branded prescribed medicines due to a lack of awareness. India is the world’s largest maker of generic medicines since its pharmaceutical sector fulfils over 50% of the global demand, still, Indians are spending their 10–20% of total income as health expenses. Aim and Objective This cross-sectional study was designed to have insight into the awareness of generic and ethical medicines among youth studying in different institutes. The main objective was to collect the responses from the students studying in various undergraduate and post-graduate professional programs. We aimed to collect 300 responses from students enrolled in various institutes located in Doaba region of Punjab. Materials and Methods A self-made questionnaire comprising basic questions based on generic and ethical medicines and Jan Aushadhi Kendra was randomly distributed amongst respondents through Google form. Conclusion According to the study’s findings, respondents had average understanding of the Jan Aushadhi Kendra. The study’s findings revealed a modest relationship between knowledge and attitude towards the Jan Aushadhi initiative. Despite the fact that the Jan Aushadhi plan was started many years ago, it has yet to gain limelight in the country.
Timing of symptomatic intracranial hemorrhage after endovascular stroke treatment
Authors: van der Steen Wouter , van der Ende Nadinda AM , van Kranendonk Katinka R , Chalos Vicky , Brouwer Josje , van Oostenbrugge Robert J , van Zwam Wim H , van Doormaal Pieter J , van Es Adriaan CGM , Majoie Charles BLM , van der Lugt Aad , Dippel Diederik WJ , Roozenbeek Bob 
Published: August 2022

Introduction: Little is known about the timing of occurrence of symptomatic intracranial hemorrhage (sICH) after endovascular therapy (EVT) for acute ischemic stroke. A better understanding could optimize in-hospital surveillance time points and duration. The aim of this study was to delineate the probability of sICH over time and to identify factors associated with its timing. Patients and methods: We retrospectively analyzed data from the Dutch MR CLEAN trial and MR CLEAN Registry. We included adult patients who underwent EVT for an anterior circulation large vessel occlusion within 6.5 h of stroke onset. In patients with sICH (defined as ICH causing an increase of ⩾4 points on the National Institutes of Health Stroke Scale [NIHSS]), univariable and multivariable linear regression analysis was used to identify factors associated with the timing of sICH. This was defined as the time between end of EVT and the time of first CT-scan on which ICH was seen as a proxy. Results: SICH occurred in 205 (6%) of 3391 included patients. Median time from end of EVT procedure to sICH detection on NCCT was 9.0 [IQR 2.9–22.5] hours, with a rapidly decreasing incidence after 24 h. None of the analyzed factors, including baseline NIHSS, intravenous alteplase treatment, and poor reperfusion at the end of the procedure were associated with the timing of sICH. Conclusion: SICHs primarily occur in the first hours after EVT, and less frequently beyond 24 h. Guidelines that recommend to perform frequent neurological assessments for at least 24 h after intravenous alteplase treatment can be applied to ischemic stroke patients treated with EVT.
Minimal residual disease–driven treatment intensification with sequential addition of ibrutinib to venetoclax in R/R CLL
Authors: Scarfò Lydia , Heltai Silvia , Albi Elisa , Scarano Eloise , Schiattone Luana , Farina Lucia , Moia Riccardo , Deodato Marina , Ferrario Andrea , Motta Marina , Reda Gianluigi , Sancetta Rosaria , Coscia Marta , Rivela Paolo , Laurenti Luca , Varettoni Marzia , Perotta Eleonora , Capasso Antonella , Ranghetti Pamela , Colia Maria , Ghia Paolo 
Published: August 2022

Abstract
Undetectable measurable residual disease (uMRD) is achievable in patients with chronic lymphocytic leukemia (CLL) with the BCL2-inhibitor venetoclax alone or combined with the Bruton’s tyrosine kinase inhibitor ibrutinib. This phase 2, multicenter, MRD-driven study was designed to discontinue treatment upon reaching uMRD4 (&lt;10−4) in patients with relapsed/refractory CLL receiving venetoclax monotherapy or after the addition of ibrutinib. Primary end point of the study was proportion of uMRD4 with venetoclax ± ibrutinib. Secondary end points were overall response rate, partial response, complete response, progression-free survival, duration of response, overall survival, and safety of venetoclax ± ibrutinib. Patients with uMRD4 at Cycle 12 Day 1 discontinued venetoclax. MRD+ patients added ibrutinib and continued both drugs up to Cycle 24 Day 28/uMRD4/progression/toxicity. After Cycle 24 Day 28, MRD+ patients continued ibrutinib. Thirty-eight patients (29% with TP53 aberrations; 79% with unmutated IGHV) started venetoclax. Overall response rate with venetoclax was 36 (95%) of 38 patients (20 complete; 16 partial response). Seventeen patients (45%) with uMRD4 at Cycle 12 Day 1 discontinued venetoclax. Nineteen (55%) MRD+ subjects added ibrutinib. After a median of 7 months (range, 3-10 months) of combined treatment, 16 (84%) of 19 achieved uMRD4, thus stopping both drugs. Two MRD+ patients at Cycle 24 Day 28 continued ibrutinib until progression/toxicity. After a median follow-up of 36.5 months, median progression-free survival was not reached; 10 patients progressed (4 restarted venetoclax, 3 without treatment need, 2 developed Richter transformation, and 1 dropped out). Seven (22%) of 32 patients remain uMRD4 after 3 years of follow-up. Neutropenia was the most frequent grade 3 to 4 adverse event; no grade 5 events occurred on study. This sequential MRD-guided approach led to uMRD4 in 33 (87%) of 38 patients, with venetoclax monotherapy or combined with ibrutinib, delivering treatment combination only in a fraction, and ultimately identifying the few patients benefiting from continuous therapy. This trial was registered at www.clinicaltrials.gov as # NCT04754035.
MALAT1-miRNAs network regulate thymidylate synthase and affect 5FU-based chemotherapy
Authors: Matuszyk Janusz 
Published: August 2022

Abstract
Background
The active metabolite of 5-Fluorouracil (5FU), used in the treatment of several types of cancer, acts by inhibiting the thymidylate synthase encoded by the TYMS gene, which catalyzes the rate-limiting step in DNA replication. The major failure of 5FU-based cancer therapy is the development of drug resistance. High levels of TYMS-encoded protein in cancerous tissues are predictive of poor response to 5FU treatment. Expression of TYMS is regulated by various mechanisms, including involving non-coding RNAs, both miRNAs and long non-coding RNAs (lncRNAs).

Aim
To delineate the miRNAs and lncRNAs network regulating the level of TYMS-encoded protein.

Main body
Several miRNAs targeting TYMS mRNA have been identified in colon cancers, the levels of which can be regulated to varying degrees by lncRNAs. Due to their regulation by the MALAT1 lncRNA, these miRNAs can be divided into three groups: (1) miR-197-3p, miR-203a-3p, miR-375-3p which are downregulated by MALAT1 as confirmed experimentally and the levels of these miRNAs are actually reduced in colon and gastric cancers; (2) miR-140-3p, miR-330-3p that could potentially interact with MALAT1, but not yet supported by experimental results; (3) miR-192-5p, miR-215-5p whose seed sequences do not recognize complementary response elements within MALAT1. Considering the putative MALAT1-miRNAs interaction network, attention is drawn to the potential positive feedback loop causing increased expression of MALAT1 in colon cancer and hepatocellular carcinoma, where YAP1 acts as a transcriptional co-factor which, by binding to the TCF4 transcription factor/ β-catenin complex, may increase the activation of the MALAT1 gene whereas the MALAT1 lncRNA can inhibit miR-375-3p which in turn targets YAP1 mRNA.

Conclusion
The network of non-coding RNAs may reduce the sensitivity of cancer cells to 5FU treatment by upregulating the level of thymidylate synthase.
Discovery of cold-resistance genes in Vitis amurensis using bud-based quantitative trait locus mapping and RNA-seq
Authors: Ma Xiaolele , Zhao Fangyuan , Su Kai , Lin Hong , Guo Yinshan 
Published: August 2022

AbstractBackgroundIn cold regions, low temperature is the main limiting factor affecting grape production. As an important breeding resource,V. amurensisRupr. has played a crucial role in the discovery of genes which confer cold resistance in grapes. Thus far, many cold-resistance genes have been reported based on the study ofV. amurensis. In order to identify more candidate genes related to cold resistance inV. amurensis, QTL mapping and RNA-seq was conducted based on the hybrid population and different cold-resistance cultivars in this study.ResultsIn this study, highly cold-resistant grape cultivar ‘Shuangyou’ (SY) which belongs toV. amurensis,and cold-sensitive cultivar ‘Red Globe’ (RG) which belongs toVitis viniferaL.were used to identify cold resistance genes. Cold-resistance quantitative trait locus (QTL) mapping was performed based on genetic population construction through interspecific crossing of ‘Shuangyou’ and ‘Red Globe’. Additionally, transcriptome analysis was conducted for the dormant buds of these two cultivars at different periods. Based on transcriptome analysis and QTL mapping, many new structural genes and transcription factors which relate toV. amurensiscold resistance were discovered, including CORs (VaCOR413IM), GSTs (VaGST-APIC,VaGST-PARB,VaGSTF9andVaGSTF13), ARFs (VaIAA27andVaSAUR71), ERFs (VaAIL1), MYBs (VaMYBR2,VaMYBLLandVaMYB3R-1) and bHLHs (VaICE1andVabHLH30).ConclusionsThis discovery of candidate cold-resistance genes will provide an important theoretical reference for grape cold-resistance mechanisms, research, and cold-resistant grape cultivar breeding in the future.
A novel, non-GMO surface display in Limosilactobacillus fermentum mediated by cell surface hydrolase without anchor motif
Authors: Vasquez Robie , Bagon Bernadette B. , Song Ji Hoon , Han Nam Soo , Kang Dae-Kyung 
Published: August 2022

AbstractRecent studies have demonstrated the potential of surface display technology in therapeutic development and enzyme immobilization. Utilization of lactic acid bacteria in non-GMO surface display applications is advantageous due to its GRAS status. This study aimed to develop a novel, non-GMO cell wall anchoring system for lactic acid bacteria using a cell-surface hydrolase (CshA) from Lactiplantibacillus plantarum SK156 for potential industrial and biomedical applications. Analysis of the CshA revealed that it does not contain any known classical anchor domains. Although CshA lacks a classical anchor domain, it successfully displayed the reporter protein superfolder GFP on the surface of several lactic acid bacteria in host dependent manner. CshA-sfGFP fusion protein was displayed greatest on Limosilactobacillus fermentum SK152. Pretreatment with trichloroacetic acid further enhanced the binding of CshA to Lm. fermentum. The binding conditions of CshA on pretreated Lm. fermentum (NaCl, pH, time, and temperature) were also optimized, resulting in a maximum binding of up to 106 CshA molecules per pretreated Lm. fermentum cell. Finally, this study demonstrated that CshA-decorated pretreated Lm. fermentum cells tolerates gastrointestinal stress, such as low pH and presence of bile acid. To our knowledge, this study is the first to characterize and demonstrate the cell-surface display ability of CshA. The potential application of CshA in non-GMO antigen delivery system and enzyme immobilization remains to be tested.
Heparin-induced thrombocytopenia post-cardiovascular interventional therapy: a case report
Authors: Shen Lishui , Liu Xiaohua , Chen Lian , Gao Xiaofei , Xu Yizhou 
Published: August 2022

Abstract
Background
Heparin-induced thrombocytopenia (HIT) is an antibody-mediated adverse drug reaction characterized by thrombocytopenia and thromboembolism. Herein, we present a case of HIT with subcutaneous hemorrhage after cardiovascular interventional therapy.

Case presentation
A 74-year-old man was admitted to the hospital for elective atrial fibrillation (AF) catheter ablation and left atrial appendage closure because of intermittent dizziness and palpitations. At presentation, the routine laboratory test results showed no abnormalities. He received subcutaneous enoxaparin for stroke prevention and unfractionated heparin for intraprocedural anticoagulation during coronary angiography and the AF procedure. On the second day after the AF procedure, the patient developed profound thrombocytopenia, moderate anemia, and mild subcutaneous hematoma. Blood tests and imaging examinations excluded acute hemolysis and other active bleeding. A 4Ts score of 5 and markedly positive platelet factor 4 IgG antibody established the diagnosis of HIT. Due to progressive subcutaneous hemorrhage in the thighs that could not be suppressed by pressure dressing, the patient received platelet transfusion and rivaroxaban for anticoagulation. The following days, the patient remained clinically stable from the hemorrhage, and his platelet count recovered. No thrombotic events occurred during hospitalization or follow-up.

Conclusion
This case emphasizes the significance of suspecting HIT in patients with unexplained rapid thrombocytopenia after frequent heparin exposure. Decision-making regarding alternative anticoagulation and platelet transfusion in HIT with hemorrhage must be based on unique patient characteristics.