bluuebunny/crossref_metadata_2025_split huggingface dataset:
Precariousness, Diabetes Control and Complications in French Guiana
Authors: Linière Samuel , Nacher Mathieu , Drak Alsibai Kinan , Mergeayfabre Mayka , Hafsi Nezha , Charpin Aurelie , Misslin-Tritsch Caroline , Carod Jean-François , Aurelus Jean Markens , De Toffol Bertrand , Ntoutoum André , Kakamba John Bukasa , Demar Magalie , Helene-Pelage Jeannie , Adenis Antoine , Sabbah Nadia 
Published: July 2022

AimsThe social parameters of an individual impact the incidence of cardiovascular diseases. French Guiana, an overseas French territory with a lower standard of living than France, has a prevalence of diabetes mellitus that is twice that of mainland France. In this context we aimed to study the relation between precariousness, diabetes complications and glycemic control.MethodsA multicenter prospective cohort was initiated since May 2019. 1243 patients were included and their outcomes and history were compared between the precarious and non-precarious based on their EPICES score, a score that measures social isolation and precariousness.Results73.3% of the sample was considered precarious. Retinopathy was significantly more frequent among the deprived. There were no significant differences for other macro or microvascular complications.There was a significant difference in Glycated Haemoglobin between the precarious and non-precarious groups (8.3% (67 mmol/l) vs 8.8% (73mmol/l)). After adjusting for potential confounders, precariousness was no longer associated with poor glycemic control; the independent factors significantly associated with poor glycemic control were: not being fluent in French, having creole or portugese as mother language, and not having any insurance.ConclusionsPrecariousness is a risk factor for retinal complications in patients with diabetes mellitus in French Guiana. In this chronic disease, the universal healthcare system alleviates health inequalities for many, but not all, diabetic complications.Translation and cultural mediation may further reduce health inequalities in this multicultural territory where a substantial proportion of the population is not fluent in French.
Bioinformatics analysis of potential common pathogenic mechanisms for COVID-19 infection and primary Sjogren’s syndrome
Authors: Luo Hong , Zhou Xia 
Published: July 2022

BackgroundAccumulating evidence has revealed that the prevalence of Coronavirus 2019 (COVID-19) was significantly higher in patients with primary Sjogren’s syndrome (pSS) compared to the general population. However, the mechanism remains incompletely elucidated. This study aimed to further investigate the molecular mechanisms underlying the development of this complication.MethodsThe gene expression profiles of COVID-19 (GSE157103) and pSS (GSE40611) were downloaded from the Gene Expression Omnibus (GEO) database. After identifying the common differentially expressed genes (DEGs) for pSS and COVID-19, functional annotation, protein-protein interaction (PPI) network, module construction and hub gene identification were performed. Finally, we constructed transcription factor (TF)-gene regulatory network and TF-miRNA regulatory network for hub genes.ResultsA total of 40 common DEGs were selected for subsequent analyses. Functional analyses showed that cellular components and metabolic pathways collectively participated in the development and progression of pSS and COVID-19. Finally, 12 significant hub genes were identified using the cytoHubba plugin, including CMPK2, TYMS, RRM2, HERC5, IFI44L, IFI44, IFIT2, IFIT1, IFIT3, MX1, CDCA2 and TOP2A, which had preferable values as diagnostic markers for COVID-19 and pSS.ConclusionsOur study reveals common pathogenesis of pSS and COVID-19. These common pathways and pivotal genes may provide new ideas for further mechanistic studies.
Molecular and clinical characteristics of ATP1A3-related diseases
Authors: Li Yinchao , Liu Xianyue , Wang Chengzhe , Su Zhengwei , Zhao Ke , Yang Man , Chen Shuda , Zhou Liemin 
Published: July 2022

ObjectiveWith detailed studies of ATP1A3-related diseases, the phenotypic spectrum of ATP1A3 has greatly expanded. This study aimed to potentially identify the mechanisms by which ATP1A3 caused neurological dysfunction by analyzing the clinical features and phenotypes of ATP1A3-related diseases, and exploring the distribution patterns of mutations in the subregions of the ATP1A3 protein, thus providing new and effective therapeutic approaches.MethodsDatabases of PubMed, Online Mendelian Inheritance in Man, and Human Gene Mutation Database, Wanfang Data, and Embase were searched for case reports of ATP1A3-related diseases. Following case screening, we collected clinical information and genetic testing results of patients, and analyzed the disease characteristics on the clinical phenotype spectrum associated with mutations, genetic characteristics of mutations, and effects of drug therapy.ResultsWe collected 902 clinical cases related to ATP1A3 gene. From the results of previous studies, we further clarified the clinical characteristics of ATP1A3-related diseases, such as alternating hemiplegia of childhood (AHC), rapid-onset dystonia-parkinsonism; cerebellar ataxia, areflexia, pes cavus, optic atrophy, and sensorineural hearing loss syndrome, and relapsing encephalopathy with cerebellar ataxia, frequency of mutations in different phenotypes and their distribution in gene and protein structures, and differences in mutations in different clinical phenotypes. Regarding the efficacy of drug treatment, 80 of the 124 patients with AHC were treated with flunarizine, with an effectiveness rate of ~64.5%.ConclusionsNervous system dysfunction due to mutations of ATP1A3 gene was characterized by a group of genotypic–phenotypic interrelated disease pedigrees with multiple clinical manifestations. The presented results might help guide the diagnosis and treatment of ATP1A3-related diseases and provided new ideas for further exploring the mechanisms of nervous system diseases due to ATP1A3 mutations.
Retroform Cervical Dystonia: Target Muscle Selection and Efficacy of Botulinum Toxin Injection
Authors: Hu Yaowen , Pan Lizhen , Su Junhui , Chen Shuzhen , Zhang Xiaolong , Pan Yougui , Jin Lingjing , Teng Fei 
Published: July 2022

IntroductionRetroform cervical dystonia (RCD), which includes retrocaput and retrocollis, is a rare form of cervical dystonia. Few reports have been published on RCD. The present study aimed to characterize the target muscles involved in RCD and the efficacy of botulinum toxin type A (BTX-A) injection.MethodsPatients with consecutive cervical dystonia with RCD as the most problematic feature were retrospectively analyzed over a 10-year period. Target muscles were screened and confirmed based on clinical evaluation, single-photon emission computed tomography, and electromyography. In addition, efficacy and adverse events following BTX-A injection in patients with RCD were evaluated.ResultsA total of 34 patients with RCD were included, 18 of whom presented with retrocaput and 16 with retrocollis. The most frequently injected muscles in RCD were splenius capitis (SPCa, 97.1%) and semispinalis capitis (SSCa, 97.1%), followed by levator scapulae (LS, 50.0%), rectus capitis posterior major (RCPM, 47.1%), trapezius (TPZ, 41.2%), and sternocleidomastoid muscle (SCM, 41.2%). Besides cervical muscles, the erector spinae was also injected in 17.6% of patients. Most muscles were predominantly bilaterally injected. The injection schemes of retrocaput and retrocollis were similar, possibly because in patients with retrocollis, retrocaput was often combined. BTX-A injection achieved a satisfactory therapeutic effect in RCD, with an average symptom relief rate of 69.0 ± 16.7%. Mild dysphagia (17.6%) and posterior cervical muscle weakness (17.6%) were the most common adverse events.ConclusionSPCa, SSCa, LS, RCPM, LS, and SCM were commonly and often bilaterally injected in RCD. Patients with RCD could achieve satisfactory symptom relief after BTX-A injection.
Decreased plasma levels of PDGF-BB, VEGF-A, and HIF-2α in preterm infants after ibuprofen treatment
Authors: Huang Xuemei , Han Dongshan , Wei Yanfei , Lin Bingchun , Zeng Dingyuan , Zhang Yu , Wei Ba , Huang Zhifeng , Chen Xueyu , Yang Chuanzhong 
Published: July 2022

IntroductionIbuprofen is one of the most common non-steroidal anti-inflammatory drugs used to close patent ductus arteriosus (PDA) in preterm infants. PDA is associated with bronchopulmonary dysplasia (BPD), while PDA closure by ibuprofen did not reduce the incidence of BPD or death. Previous studies have indicated an anti-angiogenesis effect of ibuprofen. This study investigated the change of angiogenic factors after ibuprofen treatment in preterm infants.MethodsPreterm infants with hemodynamically significant PDA (hsPDA) were included. After confirmed hsPDA by color doppler ultrasonography within 1 week after birth, infants received oral ibuprofen for three continuous days. Paired plasma before and after the ibuprofen treatment was collected and measured by ELISA to determine the concentrations of platelet-derived growth factor-BB (PDGF-BB) and vascular endothelial growth factor A (VEGF-A), and hypoxia-inducible factor-2α (HIF-2α).Results17 paired plasma from infants with hsPDA were collected. The concentration of PDGF-BB and VEGF-A significantly decreased after ibuprofen treatment (1,908 vs. 442 pg/mL for PDGF-BB, 379 vs. 174 pg/mL for VEGF-A). HIF-2α level showed a tendency to decrease after ibuprofen treatment, although the reduction was not statistically significant (p = 0.077).ConclusionThis study demonstrated decreased vascular growth factors after ibuprofen exposure in hsPDA infants.
The Efficacy and Safety of Ischemic Stroke Therapies: An Umbrella Review
Authors: Li Yongbiao , Cui Ruyi , Fan Fangcheng , Lu Yangyang , Ai Yangwen , Liu Hua , Liu Shaobao , Du Yang , Qin Zhiping , Sun Wenjing , Yu Qianqian , Liu Qingshan , Cheng Yong 
Published: July 2022

Background: Ischemic stroke is a leading cause of morbidity and mortality in neurological diseases. Numerous studies have evaluated the efficacy and safety of ischemic stroke therapies, but clinical data were largely inconsistent. Therefore, it is necessary to summarize and analyze the published clinical research data in the field.Objective: We aimed to perform an umbrella review to evaluate the efficacy and safety of ischemic stroke therapies.Methods: We conducted a search for meta-analyses and systematic reviews on PubMed, the Cochrane Library, and the Web of Science to address this issue. We examined neurological function deficit and cognitive function scores, quality of life, and activities of daily living as efficacy endpoints and the incidence of adverse events as safety profiles.Results: Forty-three eligible studies including 377 studies were included in the umbrella review. The results showed that thrombolytic therapy (tPA; alteplase, tenecteplase, and desmoteplase), mechanical thrombectomy (MTE), edaravone with tPA, stem cell-based therapies, stent retrievers, acupuncture with Western medicines, autologous bone marrow stromal cells, antiplatelet agents (aspirin, clopidogrel, and tirofiban), statins, and Western medicines with blood-activating and stasis-dispelling herbs (NaoShuanTong capsule, Ginkgo biloba, Tongqiao Huoxue Decoction, Xuesaitong injection) can improve the neurological deficits and activities of daily living, and the adverse effects were mild for the treatment of ischemic stroke. Moreover, ligustrazine, safflower yellow, statins, albumin, colchicine, MLC601, salvianolic acids, and DL-3-n-butylphthalide showed serious adverse events, intracranial hemorrhage, or mortality in ischemic stroke patients.Conclusion: Our study demonstrated that tPA, edaravone and tPA, tPA and MTE, acupuncture and Western medicines, and blood-activating and stasis-dispelling herbs with Western medicines are the optimum neurological function and activities of daily living medication for patients with ischemic stroke.Systematic Review Registration: https://inplasy.com/, identifier [INPLASY202250145].
The duration of postoperative analgesic use after total knee arthroplasty and nomogram for predicting prolonged analgesic use
Authors: Zhang Yi , Li Zihua , Su Qihang , Ge Heng’an , Cheng Biao , Tian Meimei 
Published: July 2022

BackgroundTotal knee arthroplasty is currently a reliable treatment for end-stage knee osteoarthritis. However, chronic postsurgical pain (CPSP) is substantially thought to reduce patient satisfaction. NSAID-based oral analgesics were used to manage CPSP, but research on the duration of postoperative analgesic use (DAU) and prolonged analgesic use (PAU) are presently scarce.MethodsPreoperative, perioperative, and one-year or above postoperative follow-up data were collected from 162 patients who underwent total knee arthroplasty between 1 June 2018 and 1 March 2019, and the DAU and the discontinuation time of each patient after discharge were recorded. Observational statistical analysis, diagnostic test, and predictive nomogram construction were performed on the collected data.ResultsThe 3-month DAU has good diagnostic utility for poor outcome of postoperative months twelve (POM12). The constructed nomogram shows that gender, preoperative Numeric Rating Scale (NRS) movement pain scores, duration of surgery, postoperative days three (POD3) moderate to severe movement pain, and POD3 pain rescue medication were significant prognostic predictors of PAU after discharge. The area under the curve (AUC) of the 3-month, 6-month, and 12-month nomogram receiver operating characteristic (ROC) curves were calculated to be 0.741, 0.736, and 0.781.ConclusionPAU was defined as more than three months of NSAID-based oral analgesic use after TKA. Prognostic predictors of PAU after TKA were identified, and visualized nomogram was plotted and evaluated. The evaluation indicated that the prediction model had the good predictive ability and was a valuable tool for predicting PAU after discharge.
MODUS OPERANDI TINDAK PIDANA PROSTITUSI MELALUI MEDIA SOSIAL ONLINE
Authors: Flora Henny Saida 
Published: July 2022

ABSTRAK Prostitusi online adalah pembaharuan dari tindak pidana prostitusi konvensional. Jika prostitusi konvensional hanya menggunakan sarana satu tempat, satu bangunan untuk menjalankan bisnis haramnya. Sebaliknya, prostitusi online hanya menggunakan sarana teknologi, internet yang mempermudah calon pengguna dengan pria/wanita penjaja seks komersial (PSK) ataupun antara calon pengguna dengan muncikari, perantara jasa PSK. Faktor penyebab terjadinya prostitusi online yaitu faktor internal berupa faktor dari keluarga dan pergaulan pertemanan dan Faktor eksternal berupa menghindari pelacakan petugas dan faktor ekonomi untuk memperoleh uang dalam jumlah banyak tapi cepat. Modus yang digunakan ialah menggunakan sarana pertukaran informasi elektronik, pertukaran foto, video hingga akhirnya bertemu di satu tempat untuk melakukan hubungan intim dan melakukan pembayaran atas jasa tersebut. Metode yang digunakan dalam penelitian ini adalah yuridis normatif dan menganalisis peraturan perundang-undangan yang berlaku dengan fenomena hukum, prostitusi online sesuai yang diatur dalam Undang-Undang Nomor 19 Tahun 2016 tentang Perubahan atas Undang-Undang Nomor 11 Tahun 2008 tentang Informasi dan Transaksi Elektronik.ABSTRACTOnline prostitution is a renewal of conventional prostitution. If conventional prostitution only uses one place, one building to run its illegitimate business. On the other hand, online prostitution only uses technological means, the internet which makes it easier for potential users and male/female commercial sex workers or between potential users and pimps, intermediaries for prostitution services. Factors causing online prostitution are internal factors in the form of factors from family and friendships and external factors in the form of avoiding tracking officers and economic factors to get large amounts of money quickly. The mode used is to use electronic information exchange facilities, exchange photos, and videos and finally meet in one place to have sex and make payments for these services. The method used in this research is normative juridical and analyzes the applicable laws and regulations regarding the legal phenomenon, of online prostitution as regulated in Law Number 19 of 2016 concerning Amendments to Law Number 11 of 2008 concerning Information and Electronic Transactions.
AISLAMIENTO, CARACTERIZACIÓN MOLECULAR, ANTAGONISMO Y PRODUCCIÓN ÓPTIMA DE ESPORAS DE TRICHODERMA HARZIANUM POR FERMENTACIÓN SÓLIDA APLICANDO UN SUBPRODUCTO DE ORYZA SATIVA (ARROZ) COMO SUSTRATO
Authors: Medina Carpio Oscar Christian , Vera Gutiérrez Mishell Milagros , Manrique Pino Pamela Lizeth , Del Águila Guillermo Carolina , Bardales Álvarez Roxana Margarita 
Published: July 2022

El tratamiento agrícola moderno afecta a los suelos reduciendo su flora microbiana y estimula a los patógenos a resistir el efecto de los agroquímicos, si bien en el mercado existe opciones biológicas estas no son competitivas, se realizan diferentes esfuerzos por desarrollar controladores biológicos que aumente el porcentaje de esporas viables, mejor desempeño del diseño de sustrato y antagonismo agresivo contra el patógeno, para realizar estas evaluaciones la presente investigación aplicó un diseño factorial aleatorio resultando una matriz de 20 unidades experimentales para determinar los valores de concentración para el diseño del sustrato y viabilidad óptima de esporas de Trichoderma spp. por fermentación sólida aplicando un subproducto de Oryza sativa (arroz) como sustrato.
Se identificaron molecularmente las cepas de estudio como Trichoderma Harzianum sp. y Fusarium oxisporum sp. los cuales fueron enfrentados en ensayos de antagonismo identificando un comportamiento competitivo e inhibidor del Trichoderma Harzianum sp., se identificaron valores de concentración y porcentaje de viabilidad óptimos durante la experimentación siendo de 3.7925 x 108 UFC /mL y un 86.74% respectivamente resultantes de 250 g de arrocillo, con 15 mL de melaza al 15% de concentración, 2.5 mL de inóculo y aireación con perforaciones finas a 5 cm de altura por encima del sustrato y espaciadas por 3 cm entre ellas. El óptimo teórico mostró valores de 4.13x 108 UFC/mL de concentración y 85.15% de viabilidad. Finalmente, la acción antagónica de Trichoderma spp. frente a Fusarium spp. por cultivo dual fue de 70.3190% en promedio de las tres repeticiones realizadas.
Cuidado de la persona con problemas mentales, desafío de la ética hacia la aproximación de la enfermería holística en un nosocomio de nivel III de Lambayeque
Authors: Rodríguez Olivos Gina Salome , Cervera Vallejos Mirtha Flor , Linares Olano Ingrid Asucena 
Published: July 2022

Objetivo: Describir y analizar el cuidado de la persona con problemas mentales como desafío de la ética con aproximación a la enfermería holística en un Nosocomio de Nivel III, del departamento de Lambayeque. Método: Investigación con bosquejo cualitativo, descriptivo exploratorio. Intervinieron 8 enfermeras del nosocomio descrito con consentimiento informado; el muestreo fue no probabilístico y la muestra fue lograda por saturación y redundancia. En la recolección de la información se utilizó la entrevista semiestructurada, validada por juicio de tres expertos y estudio piloto. Los datos obtenidos se procesaron por análisis de contenido temático con aval de principios éticos y rigor científico. Resultados principales: Afloraron tres categorías: Seguridad y protección de la vida del paciente con problema mental como un todo. Prácticas éticas y armonización del cuidado de la persona con problemas mentales. Perfilándose con capacitación para nutrir la integridad humana de la persona con problema mental. Conclusión general: Las enfermeras que laboran en el servicio de psiquiatría disciernen sobre sus prácticas éticas y razonan sobre la forma como armonizan el cuidado para llegar no solo a cuidar el cuerpo del paciente sino también su mente y espíritu, logrado con años de experiencia, con atención en sus necesidades integrales desde su higiene hasta su sueño, sabiéndoles orientar en la verdadera espiritualidad, sin dejar de lado a la familia que a veces se muestra confundida y llena de problemas.
Estimación de fibra dietética en estudiantes universitarios
Authors: Tapia Diaz Angela , Risco de Bocanegra Dolores Domitila 
Published: July 2022

Objetivo: Determinar la estimación de fibra dietética de los estudiantes de enfermería de una universidad particular, Chiclayo 2020. Método: Este estudio fue de tipo cuantitativo, el diseño fue no experimental, descriptivo, transversal. La población estuvo constituida por 294 estudiantes de la escuela de enfermería, la muestra fue estratificada de 164 estudiantes, seleccionados por muestreo aleatorio simple. Como técnica se utilizó la encuesta y el instrumento fue el “Cuestionario de frecuencia de consumo de alimentos” y un “Recordatorio de 24 horas (R24H)”. En la investigación se tuvieron en cuenta los criterios de rigor científico y principios éticos de Belmont, y para el procesamiento de los datos se utilizó el programa SPSS v 25. Resultados principales: La media de consumo de fibra dietética de los estudiantes de enfermería fue de 15,37 gr/día; en cuanto a frecuencia de consumo de alimentos según fuente alimentaria, se halló un consumo dentro de lo recomendado, en los grupos de granos (55,5%), leguminosas (48,8%), carnes (58,5%), grasas y azúcares agregadas (55,5%) , pero bajos en frutas (36,6%), vegetales (37,8), lácteos (33,5%) y agua (44,5%) Conclusión principal: La estimación de consumo de fibra dietética gr/día es inferior a lo recomendado por la Organización Mundial de la Salud- Organización de las Naciones unidas para la Alimentación y Agricultura.
Espiritualidad en adultos mayores y sus beneficios en salud: una revisión narrativa
Authors: Aponte-Franco Sandra Milena , Guerrero-Castañeda Raúl Fernando 
Published: July 2022

Objetivo: identificar los beneficios de la espiritualidad en la salud del adulto mayor. Método: revisión bibliográfica narrativa, se efectuó una búsqueda bibliográfica de artículos originales publicados durante 2017-2021, en las bases de datos PubMed, Tripdata Base, Cochrane, BVS, ScienceDirect y Lilacs utilizando los descriptores: espiritualidad, ancianos, adultos mayores y salud en idiomas: español, portugués e inglés, se realizó búsqueda avanzada y luego se verificaron cumplimiento de los criterios de exclusión e inclusión, finalmente se validó mediante la aplicación de guías metodológicas obteniéndose una muestra de 25 documentos. Resultados principales: los artículos seleccionados fueron de tipo cualitativos, cuantitativos y mixtos; siguiendo el análisis del contenido se agruparon en categorías centrales: espiritualidad y actitud positiva hacia la vida y el bienestar; espiritualidad y fortalecimiento de la salud mental; espiritualidad y bienestar biofísico; cuidado espiritual e importancia de su abordaje desde la enfermería y los profesionales de salud. Conclusiones principales: el mayor interés de abordar la espiritualidad en los adultos mayores se relaciona con los procesos patológicos y la forma de abordarlos de una manera más efectiva, además mejorando su conducta relacionada con la salud. Para futuros estudios se requieren investigaciones que profundicen en acciones específicas desde ciencias de la salud, enfermería y otras áreas del conocimiento.