bluuebunny/crossref_metadata_2025_split huggingface dataset:
Collagen matrix biofunctionalized with injectable platelet‐rich fibrin for the treatment of single gingival recession: A case report
Authors: Santamaria Mauro Pedrine , Rossato Amanda , Ferreira Ferraz Laís Fernanda , Bonafé Ana Carolina , Miguel Manuela Maria Viana , Nunes Marcelo Pereira 
Published: May 2022

AbstractIntroductionCollagen matrices have been used as connective tissue graft (CTG) substitutes. However, they do not have the same efficacy compared to CTG. Adding biological agents may increase collagen matrices' efficacy. The present case reports the use of a biofunctionalized volume‐stable collagen matrix (VCMX) with injectable platelet‐rich fibrin (iPRF) associated with the coronally advanced flap (CAF) to treat single gingival recession (GR) defect.Case PresentationA Recession Type 1 (RT1 A‐) defect at maxillary left canine in a male patient was treated using a VCMX biofunctionalized with iPRF associated with CAF. No swelling or edema was observed during the first 14 days after surgery. Complete root coverage was observed (RecRed of 4.0 mm) after 6 months. Gingival thickness (GT) increased (1.0 mm) by the end of the follow‐up.ConclusionThe present case report shows that CAF associated with VCMX+iPRF presents good clinical outcomes for single GR defect.Key pointsWhy is this case new information?

This case is the first one to our knowledge to describe the biofunctionalization of VCMX with iPRF to treat single gingival recession.
What are the keys to successful management of this case?

Proper material handling.
Proper iPRF protocol execution.
What are the primary limitations to success in this case?

Need of venipuncture.
Correct preparation of VCMX+iPRF.
Patient compliance.
N‐terminal Cationic Modification of Linear Pyrrole‐Imidazole Polyamide Improves Its Binding to DNA
Authors: Hatanaka Junnosuke , Hirose Yuki , Hashiya Kaori , Bando Toshikazu , Sugiyama Hiroshi 
Published: May 2022

AbstractPyrrole‐imidazole polyamides (PIPs) bind to double‐stranded DNA (dsDNA) with varied sequence selectivity. We synthesized linear PIPs that can bind to narrow minor grooves of polypurine/polypyrimidine sequences and target long recognition sequences but have lower molecular weights than commonly used hairpin PIPs. We modified the N‐terminus of linear PIPs using several groups, including β‐alanine extension and acetyl capping. Melting curve analysis of dsDNA demonstrated that cationic modifications improved the binding affinity of the PIPs to the targeted dsDNA. In addition, circular dichroism assays revealed the characteristic spectra depending on the binding stoichiometry of the N‐cationic linear PIP and dsDNA (1 : 1, monomeric; 2 : 1, dimeric). Surface plasmon resonance assays confirmed the high binding affinities of linear PIPs. These findings may aid in the design of effective linear PIPs.
Gas‐phase errors affect DFT‐based electrocatalysis models of oxygen reduction to hydrogen peroxide
Authors: Almeida Michell O. , Kolb Manuel J. , Lanza Marcos R. V. , Illas Francesc , Calle‐Vallejo Federico 
Published: May 2022

AbstractInvited for this month's cover picture is the group of Federico Calle‐Vallejo and Francesc Illas from the University of Barcelona (Spain). The cover picture shows that there are three ways of simulating the energy landscape of oxygen reduction to hydrogen peroxide with density functional theory: without any corrections (yellow), with O2 corrections (yellow/red), and with O2 and H2O2 corrections (red); only the latter agrees with experiments. Read the full text of the Research Article at 10.1002/celc.202200210
The Unexpected Helical Supramolecular Assembly of a Simple Achiral Acetamide Tecton Generates Selective Water Channels
Authors: Dumitrescu Dan G. , Rull‐Barull Jordi , Martin Anthony R. , Masquelez Nathalie , Polentarutti Maurizio , Heroux Annie , Demitri Nicola , Bais Giorgio , Moraru Ionut‐Tudor , Poteau Romuald , Amblard Muriel , Krajnc Andraž , Mali Gregor , Legrand Yves‐Marie , van der Lee Arie , Legrand Baptiste 
Published: May 2022

AbstractInvited for the cover of this issue is the collaborative research team coordinated by Arie van der Lee at the University of Montpellier. The image depicts chiral channels with highly mobile water molecules resulting from the robust self‐organization of a simple achiral acetamide. Fully reversible release and re‐uptake of water molecules takes place near ambient conditions, with efficient water transport and a good selectivity against NaCl suggesting it to be an efficient candidate for desalination processes. Read the full text of the article at 10.1002/chem.20200383.
Primary eosinophilic gastrointestinal disorders and allergy: Clinical and therapeutic implications
Authors: Rossi Carlo Maria , Lenti Marco Vincenzo , Merli Stefania , Licari Amelia , Votto Martina , Marseglia Gian Luigi , Di Sabatino Antonio 
Published: May 2022

AbstractPrimary eosinophilic gastrointestinal disorders (EGID) are increasingly prevalent, immune‐mediated, chronic conditions which primarily affect pediatric and young adult patients, leading to substantial disease burden, and poor quality of life. EGID may either involve single portions of the gastrointestinal tract (i.e., esophagus, stomach, small bowel, and colon) or a combination. Their strong association with allergic disorders has been recently recognized, and although their shared pathophysiological basis remains partly elusive, this feature greatly impacts the diagnostic and treatment work‐up. We herein critically discuss the current knowledge on the association of EGID and allergic disorders, including atopic dermatitis, allergic rhinitis, allergic asthma, and food or drug allergy. In particular, we reviewed the literature focusing on their epidemiology, pathophysiological basis and mechanisms, and diagnostic strategies. Finally, we discuss the currently ongoing clinical trials targeting EGID and allergic diseases, including, among others the monoclonal antibodies dupilumab, mepolizumab, benralizumab, and lirentelimab.
Deep malware hunter based unrivaled malware detection schema thru cache retrospective empiricism
Authors: Shelar Manoj D. , Srinivasa Rao S. 
Published: May 2022

AbstractMalware development has been tremendous in recent decades, posing a severe threat to modern systems and Internet security. Conventional approaches to malware detection focus solely on data stored on hard disc drives. To prevent detection, the attackers put harmful material in volatile memory and attack sensitive confidential data. Furthermore, static signature‐based malware detection approaches require a recognized malware signature database to detect the malware. These efforts, however, failed because the malware rapidly modified its signature and easily evaded detection by packaging, obfuscating, or encrypting. As a consequence, it is vital to extract appropriate memory characteristics and let the deep learning classifier that learns the features improve malware detection accuracy. Therefore, in this paper, we propose a Deep Malware Hunter Based Unrivaled Malware Detection Scheme that skillfully detects known and unknown malware without harming the device. In this way, our Unrivaled Malware Detection Scheme efficiently extracts the necessary features through sharp inspection and classifies the malware correctly and benignly at an early stage before it attacks the device. Thus the proposed framework efficiently provides an accuracy of 99% detection rate in the malware hunter method.
Single‐cell profiling guided combination therapy of c‐Fos and histone deacetylase inhibitors in diffuse large B‐cell lymphoma
Authors: Krämer Oliver H. , Schneider Günter 
Published: May 2022

AbstractIn this commentary on Wang, Wu, Xia, and colleagues, Clinical Translational Medicine, 2022, we sum up and discuss recent evidence on the regulation and relevance of the transcription factor c‐FOS in diffuse large B cell lymphoma cells that are treated with epigenetic erasers of the histone deacetylase inhibitor family.
Core‐SOL simulations of high‐power JET‐ILW pulses fuelled with gas and/or with pellets
Authors: Telesca Giuseppe , Chomiczewska Agata , Frigione Domenico , Garzotti Luca , Huber Alexander , Ivanova‐Stanik Irena , Kowalska‐Strzeciwilk Ewa , Lomas Peter , Perez von Thun Christian , Rimini Fernanda , Van Eester Dirk , Zagórski Roman ,   JET Contributors
Published: May 2022

AbstractExperimental analysis of two couples of pulses in the range of input power of 26–32 MW, shows that addition of pellet throughput to high gas dosing pulses does not modify the plasma energy, but leads to better conditions as far as the tungsten concentration and core radiation are concerned. Significantly decreasing the gas dosing with addition of high pellet throughput causes the increase of plasma energy, but the W concentration increases from 5.2 × 10−5 to 6.9 × 10−5 and the core radiation from 7.5 to 11 MW. From the numerical results of the self‐consistent core‐SOL COREDIV code two mechanisms appear to be responsible for the observed different W concentrations: the core residence time of W, which is related to the energy and particle confinement time, and the divertor impurity screening efficiency, dependent on the electron density and on the perpendicular transport coefficient in the SOL.
An evaluation of public initiatives to change behaviours that affect water quality
Authors: Grilli Gianluca , Curtis John 
Published: May 2022

AbstractPollution and environmental depletion are often caused by human behaviours, where if behaviours were modified, environmental pressure could be substantially reduced. Many public programmes aim to influence people to change their unsustainable behaviours but few undertake ex post evaluations of behavioural change programmes. This paper undertakes an evaluation of a 5‐year programme to understand whether community engagement activities lead to more sustainable practices. Using a treatment and control experiment, the research investigates whether programme participants are representative of the wider population, whether participation leads to sustainable practices, whether pro‐environmental behaviours are sustained over time, and the relative effectiveness of different types of events on individual behaviours. Overall, results suggest that water engagement event participants are more likely to adopt sustainable behaviours, however attendees only represent a small cohort of the wider population, which possibly hinders a wider adoption of good practices. With respect to individual behaviours, different outcomes were detected for different behaviours, which suggests that not all behaviours were equally amenable to change. When comparing the impact of different events, events that are focused on building community ties were more successful than events with simple provision of information. Finally, new pro‐environmental behaviours tend to be abandoned after a period of time, therefore re‐engagement at regular time intervals is advised.
Sex differences in efficacy of pharmacological therapies in heart failure with reduced ejection fraction: a meta‐analysis
Authors: Danielson Cecilia , Lileikyte Gabriele , Ouwerkerk Wouter , S.P. Lam Carolyn , Erlinge David , Teng Tiew‐Hwa Katherine 
Published: May 2022

AbstractAimsRecent studies have suggested potential sex differences in treatment response to pharmacological therapies in heart failure (HF). We performed a systematic review and meta‐analysis of studies comparing treatment effects between men and women with HF and reduced ejection fraction (HFrEF) using established guideline‐directed medical therapy and other emerging pharmacological treatments.Methods and resultsSystematic search was performed on PubMed, Embase, and Cochrane Library for randomized controlled trials published in 1990–2021. Outcomes were all‐cause mortality and combined outcome of all‐cause mortality and/or hospitalization for HF. Of 618 articles identified, 25 articles and 100 213 patients (mean age 62 ± 1.7 years, women 23.1%, mean left ventricular ejection fraction 26.6 ± 1.3%) were included in the systematic review and meta‐analysis. For the outcome of all‐cause mortality, there was no evidence of treatment heterogeneity by sex for renin‐angiotensin system inhibitors (RASi) [hazard ratio (HR) 0.86 (95% confidence interval 0.75–0.99) in men; HR 0.97 (0.77–1.23) in women; Pinteraction = 0.288], or for beta‐blockers (BB) [HR 0.71 (0.59–0.86) in men; HR 0.87 (0.73–1.03) in women; Pinteraction = 0.345]. Similarly, for the composite outcome of death or HF hospitalization, there was no evidence of treatment heterogeneity by sex for RASi [HR 0.84 (0.77–0.93) in men; HR 0.94 (0.81–1.08) in women; Pinteraction = 0.210] or BB [HR 0.76 (0.64–0.90) in men; HR 0.72 (0.60–0.86) in women; Pinteraction = 0.650]. Results for mineralocorticoid receptor antagonists (MRA) and sodium‐glucose cotransporter‐2 inhibitors (SGLT2i) from previously published meta‐analyses were included in the review. For the combined outcome of cardiovascular death or HF hospitalization, no significant interaction for sex was observed for MRA (Pinteraction = 0.78) or SGLT2i (Pinteraction = 0.37). Results for emerging pharmacological treatments, such as soluble guanylate cyclase stimulators and cardiac myosin activators, were included in the review and showed consistent treatment effects between men and women.ConclusionsOur meta‐analysis showed no differences between sex in treatment effect for BB and RASi. Review on previously published trials for MRA, SGLT2i, and emerging therapies presented consistent treatment effects between men and women.
Recent development of aqueous zinc‐ion battery cathodes and future challenges: Review
Authors: Fegade Umesh , Jethave Ganesh , Khan Firoz , Al‐Ahmed Amir , Karmouch Rachid , Shariq Mohammad , Inamuddin  , Ahmer Mohammad Faraz 
Published: May 2022

SummaryDue to the increasing energy demand and to help integrate renewable energy into the energy mix, large‐scale energy storage has become essential. Among the different large‐scale secondary battery technologies, zinc‐ion batteries (ZIBs) have attracted huge attention due to their lower cost, better safety, and environmental positivity. The aqueous electrolyte in ZIBs allows the batteries to be constructed under normal atmospheric conditions and substantially reduces the assembling complexity. However, due to its low working voltage, cathode materials are often restricted, and rectifying voltage is a crucial function. Increasing the cathode voltage necessitates an increase in the electrolyte's thermodynamic stability. Additionally, the process of zinc‐ion storage should be studied in greater depth and new variants of characterization can be used to precisely understand the storage mechanism. In this regard, this article has reviewed with recent research findings addressing these issues and possible advancements made in the ZIB technology, highlighting future possibilities.
Metal‐organic frameworks and their derivatives as anode material in lithium‐ion batteries: Recent advances towards novel configurations
Authors: Kaur Rajnish , Chhabra Varun A. , Chaudhary Vikas , Vikrant Kumar , Tripathi Surya Kant , Su Yanjie , Kumar Parveen , Kim Ki‐Hyun , Deep Akash 
Published: May 2022

SummaryLithium‐ion batteries (LIBs) have drawn extensive research interests due to their noticeably enhanced gravimetric energy density relative to other chemical batteries. The potential utility of metal‐organic frameworks (MOFs) and their derivatives has recently been recognized as highly effective anode components for LIBs because they can be tuned to select specific metal sites and/or to adjust pore sizes. In this work, their electrochemical performance as anodic materials is carefully evaluated with respect to lithium‐ions storage capacity, energy/power, stability, and flexibility. Furthermore, through the coordination of the organic linker and metal center, MOFs can benefit from enhanced catalytic activities in the design of advanced LIBs. For future research for next‐generation LIBs, scientific focus should be placed on the development of diverse features of MOF‐based composites such as core‐shell MOFs, mono/bi‐metal doped MOFs, dual organic linker‐based MOFs, MOFs@MOFs core shell structure, and dual organic ligands‐based MOF. As such, MOF‐based LIB electrode materials are expected to expand their utility with the improvement in topology and functionality in association with the dimensionality, pore size, and surface area.
Development of Pt/Au‐Co composite electrode as a highly durable and efficient electrocatalyst for methanol electro‐oxidation in alkaline media
Authors: Begum Humayra , Rahman Mohammed M. , Hasnat Mohammad A. 
Published: May 2022

SummaryPt metal is well known for exhibiting superior catalytic activity towards methanol electro‐oxidation process but, it is highly poisoned by the intermediate carbonaceous species (CO) which degrade the catalytic activity over time. In this regard, a noble trimetallic electrode was prepared by modifying an unsupported polycrystalline Pt electrode with a mixture of Au and Co through a simple, one‐step electrochemical deposition technique for investigating the methanol electro‐oxidation (MEO) process in alkaline media. Cyclic voltammetric experiment has revealed that the as‐prepared electrode exhibited more than 50% greater stability than those of polycrystalline Pt ((poly) Pt) and Pt/Au electrodes. Moreover, the ratio of forward MEO oxidation peak current and corresponding backward peak current (If/Ib) was found to be greater for Pt/Au‐Co than (poly) Pt electrode suggesting substantial resistance of the catalyst for CO adsorption. The XPS analysis has demonstrated that Co existed on the electrode surface as Co(II) oxide which is assumed to enhance the stability of Pt/Au‐Co by removing CO species. A relatively smaller Tafel slope (130 mV/dec) was also obtained with Pt/Au‐Co than that of commercially available carbon‐supported Pt catalyst and, the oxidation process was observed to follow half order kinetics concerning methanol.
A dynamic covalent polymeric antimicrobial for conquering drug‐resistant bacterial infection
Authors: Huang Fan , Cai Xiaoyao , Hou Xiaoxue , Zhang Yumin , Liu Jinjian , Yang Lijun , Liu Yong , Liu Jianfeng 
Published: May 2022

AbstractIncreasing bacterial drug resistance to antibiotics has posed a major threat to contemporary public health, which resulted in a large number of people suffering from serious infections and ending up dying without any effective therapies every year. Here, a dynamic covalent polymeric antimicrobial, based on phenylboronic acid (PBA)‐installed micellar nanocarriers incorporating clinical vancomycin and curcumin, is developed to overcome drug‐resistant bacterial infections. The formation of this antimicrobial is facilitated by reversible dynamic covalent interactions between PBA moieties in polymeric micelles and diols in vancomycin, which impart favorable stability in blood circulation and excellent acid‐responsiveness in the infection microenvironment. Moreover, the structurally similar aromatic vancomycin and curcumin molecules can afford π–π stacking interaction to realize simultaneous delivery and release of payloads. In comparison with monotherapy, this dynamic covalent polymeric antimicrobial demonstrated more significant eradication of drug‐resistant bacteria in vitro and in vivo due to the synergism of the two drugs. Furthermore, the achieved combination therapy shows satisfied biocompatibility without unwanted toxicity. Considering various antibiotics contain diol and aromatic structures, this simple and robust strategy can become a universal platform to combat the ever‐threatening drug‐resistant infectious diseases.
Functional nucleic acid engineered double‐barreled nanopores for measuring sodium to potassium ratio at single‐cell level
Authors: Shi Xiao‐Mei , Liu Fang‐Qing , Wang Bing , Yu Si‐Yuan , Xu Yi‐Tong , Zhao Wei‐Wei , Jiang Dechen , Chen Hong‐Yuan , Xu Jing‐Juan 
Published: May 2022

AbstractThe use of double‐barreled nanopipette (θ‐nanopipette) to electrically sample, manipulate, or detect biomaterials has recently seen strong growth in single‐cell studies, driven by the potential of the nanodevices and applications that they may enable. Considering the pivotal roles of Na/K ratio (RNa/K) at cellular level, herein we describe an engineered θ‐nanopipette for measuring single‐cell RNa/K. The two independently addressable nanopores, located within one nanotip, allow respective customization of functional nucleic acids but simultaneous deciphering of Na and K levels inside a single cell of a non‐Faradic manner. Two ionic current rectification signals, corresponding to the Na‐ and K‐specific smart DNA responses, could be easily used to derive the RNa/K. The applicability of this nanotool is validated by practical probing intracellular RNa/K during the drug‐induced primary stage of apoptotic volume decrease. Especially, the RNa/K has been shown by our nanotool to be different in cell lines with different metastatic potential. This work is expected to contribute to futuristic study of single‐cell RNa/K in various physiological and pathological processes.
The impact of wood dust on pulmonary function and blood immunoglobulin E, erythrocyte sedimentation rate, and C‐ reactive protein: A cross‐sectional study among sawmill workers in Tangail, Bangladesh
Authors: Mogal Md. Roman , Islam Md. Didarul , Hasan Md. Ikbal , Junayed Asadullah , Sompa Sagarika Adhikary , Mahmod Md. Rashel , Akter Aklima , Abedin Md. Zainul , Sikder Md. Asaduzzaman 
Published: May 2022

AbstractBackground and AimsOccupational exposure to wood dust leads to lung function abnormalities that are prominent causes of morbidity and disability of sawmill workers. The adverse respiratory effects of wood dust in sawmills have not been studied thoroughly in Bangladesh. This study aimed to investigate the effect of wood dust on the respiratory health of sawmill workers compared to controls as well as to determine the association of wood dust‐exposing effects with inflammatory blood biomarkers, such as immunoglobulin E (IgE), erythrocyte sedimentation rate (ESR), and C‐reactive protein (CRP).MethodsThis cross‐sectional study included 100 sawmill workers from 25 distinct sawmills in various areas of Tangail, Bangladesh as well as 100 healthy volunteers who were adopted as a control group. Questionaries' survey and pulmonary function tests were performed face to face. Furthermore, after performing lung function tests, blood was drawn for further IgE, ESR, and CRP analyses.ResultsRespiratory symptoms including breathlessness (32%), coughing (39%), sneezing (43%), chest tightness (30%), and itching (40%) were significantly higher in sawmill workers compared with control. Besides, sawmill workers' exposure to wood dust revealed a significantly lower level of spirometry parameters (forced vital capacity ​​​​​[FVC], FVC (%), forced expiratory volume in 1 s [FEV1], FEV1 (%), peak expiratory flow [PEF], PEF (%), FEV1/FVC (%), FEF25, FEF75, and FEF2575) compared with control and these spirometry parameters decreased with the increasing length of service. Moreover, a significantly higher level of IgE was observed in sawmill workers (290.90 ± 39.49) than in the control (120.95 ± 23.00). The high level of IgE suggests that the lower pulmonary function may be linked to allergic responses to wood dust among sawmill workers.ConclusionThis study suggested that exposure to wood dust can cause impairment of respiratory function along with high IgE levels.