bluuebunny/crossref_metadata_2025_split huggingface dataset:
Targetable IDH1 mutation identified in a rare case of pancreatic serous cystadenocarcinoma but not a series of serous cystadenomas
Authors: Zhang Yuxi , Hammonds Autumn , Tran-Harding Karen , Schaberg Kurt B , Nair Rashmi T , Wang Chi , Wu Yuanyuan , Pandalai Prakash K , Kolesar Jill , Kim Joseph , Cavnar Michael J 
Published: March 2022

AbstractSerous cystadenocarcinoma (SCAC) of the pancreas is rare, with only 35 cases reported in the literature. We present a case of SCAC, comparing the clinical presentation, management and molecular features of this case to a series of serous cystadenoma (SCA), which may be a precursor. Compared with SCAs (n = 5), SCAC was larger (11.5 vs median 3.6 cm). The case of SCAC invaded the spleen and exhibited distant metastasis, a requirement for diagnosis since pathologic features are otherwise indistinguishable from SCA. VHL mutations have been reported in about half of SCA in the literature. Accordingly, we identified either somatic or germline VHL mutations in 3 of 5 SCAs (60%), yet no pathogenic mutation was identified in the SCAC. A somatic mutation in IDH1 was found in SCAC only. This has been associated with multiple malignancies, is targetable with the drug ivosidenib and should be studied as a progression factor in SCAC.
Global burden and trends of neglected tropical diseases from 1990 to 2019
Authors: Lin Yushi , Fang Kailu , Zheng Yang , Wang Hong-liang , Wu Jie 
Published: March 2022

Abstract

Background
An updated analysis of neglected tropical diseases (NTDs) from a global perspective is missing from the literature. We aimed to assess the global burden and trends of NTDs from 1990 to 2019.

Methods
Yearly incident case, mortality and disability-adjusted life years (DALYs) data for NTDs were extracted from the Global Burden of Disease Study 2019 (GBD 2019) based on global, regional, country, social development index (SDI), age and sex categories. The age-standardized rate (ASR) and number of incident cases, mortality and DALYs were computed from 1990 to 2019. The estimated annual percentage change (EAPC) in the ASR was calculated to quantify the changing trend.

Results
Globally, the age-standardized incidence rate (ASIR) and the number of incident cases of total NTDs increased between 1990 and 2019, whereas the age-standardized mortality rate (ASMR), mortality, age-standardized DALY rate and DALYs of total NTDs decreased. Although tropical Latin America, South Asia, Southeast Asia and Oceania had the highest ASIR for total NTDs in 2019, tropical Latin America was the only region to experience a decreasing trend in ASIR from 1673.5 per 100 000 in 2010 to 1059.2 per 100 000 in 2019. The middle, high-middle and high SDI regions experienced increasing ASIR trends between 1990 and 2019, whereas the low-middle SDI region remained stable, and the low SDI region presented a decreasing trend. Children and older adults were vulnerable to dengue, rabies and leishmaniasis (cutaneous and mucocutaneous). Females had a higher ASIR but a lower ASMR and age-standardized DALY rate than males.

Conclusions
NTDs still represent a serious problem for public health, and the increasing ASIR and incident cases globally may require more targeted strategies for prevention, control and surveillance, especially among specific populations and endemic areas.
A cautionary tale of Ly C escape fraction estimates from high-redshift galaxies
Authors: Bassett R , Ryan-Weber E V , Cooke J , Meštrić U , Prichard L J , Rafelski M , Iwata I , Sawicki M , Gwyn S , Arnouts S 
Published: March 2022

ABSTRACTMeasuring the escape fraction, fesc, of ionizing, Lyman continuum (Ly C) radiation is key to our understanding of the process of cosmic reionization. In this paper, we provide a methodology for recovering the posterior probability distribution of the Ly C escape fraction, $f_{\rm esc}^{\rm PDF}$, considering both the observational uncertainties and ensembles of simulated transmission functions through the intergalactic medium (IGM). We present an example of this method applied to a VUDS galaxy at z = 3.64 and find $f_{\rm esc}^{\rm PDF}$ = 0.51$^{+0.33}_{-0.34}$ and compare this to the values computed assuming averaged IGM transmission with and without consideration of detection bias along average sightlines yielding $f_{\rm esc}^{\langle T \rangle }$ = 1.40$^{+0.80}_{-0.42}$ and $f_{\rm esc}^{\rm bias}$ = 0.82$^{+0.33}_{-0.16}$. Our results highlight the limitations of methods assuming average, smooth transmission functions. We also present MOSFIRE data for a sample of seven Ly C candidates selected based on photometric redshifts at z &gt; 3.4, but find that all seven have overestimated photometric redshifts by Δz ∼ 0.2 making them unsuitable for Ly C measurements. This results likely due to a bias induced by our selection criteria.
Multimodal imaging of hemorrhagic transformation biomarkers in an ischemic stroke model.
Authors: Pushie M J , Messmer M , Sylvain N J , Heppner J , Newton J M , Hou H , Hackett M J , Kelly M E , Peeling L 
Published: March 2022

Abstract
Hemorrhagic transformation of ischemic stroke has devastating consequences, with high mortality and poor functional outcomes. Animal models of ischemic stroke also demonstrate the potential for hemorrhagic transformation, which complicates biochemical characterization, treatment studies, and hinders poststroke functional outcomes in affected subjects. The incidence of hemorrhagic transformation of ischemic stroke in animal model research is not commonly reported. The postmortem brain of such cases presents a complex milieu of biomarkers due to the presence of healthy cells, regions of varying degrees of ischemia, dead and dying cells, dysregulated metabolites, and blood components (especially reactive Fe species released from lysed erythrocytes). To improve the characterization of hemorrhage biomarkers on an ischemic stroke background, we have employed a combination of histology, X-ray fluorescence imaging (XFI), and Fourier transform infrared (FTIR) spectroscopic imaging to assess 122 photothrombotic (ischemic) stroke brains. Rapid freezing preserves brain biomarkers in situ and minimizes metabolic artifacts due to postmortem ischemia. Analysis revealed that 25% of the photothrombotic models had clear signs of hemorrhagic transformation. The XFI and FTIR metabolites provided a quantitative method to differentiate key metabolic regions in these models. Across all hemorrhage cases, it was possible to consistently differentiate otherwise healthy tissue from other metabolically distinct regions, including the ischemic infarct, the ischemic penumbra, blood vessels, sites of hemorrhage, and a region surrounding the hemorrhage core that contained elevated lipid oxidation. Chemical speciation of deposited Fe demonstrates the presence of heme-Fe and accumulation of ferritin.
Pain descriptors and determinants of pain sensitivity in knee osteoarthritis: a community-based cross-sectional study
Authors: Vriezekolk Johanna E , Peters Yvonne A S , Steegers Monique A H , Blaney Davidson Esmeralda N , van den Ende Cornelia H M 
Published: March 2022

Abstract

Objectives
The aim was to explore pain characteristics in individuals with knee OA (KOA), to compare pain sensitivity across individuals with KOA, individuals with chronic back pain (CBP) and pain-free individuals (NP) and to examine the relationship between clinical characteristics and pain sensitivity and between pain characteristics and pain sensitivity in KOA.

Methods
We carried out a cross-sectional, community-based online survey. Two data sets were combined, consisting of Dutch individuals ≥40 years of age, who were experiencing chronic knee pain (KOA, n = 445), chronic back pain (CBP, n = 504) or no pain (NP, n = 256). Demographic and clinical characteristics, global health, physical activity/exercise and pain characteristics, including intensity, spreading, duration, quality (short-form McGill pain questionnaire) and sensitivity (pain sensitivity questionnaire), were assessed. Differences between (sub)groups were examined using analyses of variance or χ2 tests. Regression analyses were performed to examine determinants of pain sensitivity in the KOA group.

Results
The quality of pain was most commonly described as aching, tender and tiring–exhausting. Overall, the KOA group had higher levels of pain sensitivity compared with the NP group, but lower levels than the CBP group. Univariately, pain intensity, its variability and spreading, global health, exercise and having co-morbidities were weakly related to pain sensitivity (standardized β: 0.12–0.27). Symptom duration was not related to pain sensitivity. Older age, higher levels of continuous pain, lower levels of global health, and exercise contributed uniquely, albeit modestly, to pain sensitivity (P &lt; 0.05).

Conclusion
Continuous pain, such as aching and tenderness, in combination with decreased physical activity might be indicative for a subgroup of individuals at risk for pain sensitivity and, ultimately, poor treatment outcomes.
The Cross-Section of Cryptocurrency Returns
Authors: Borri Nicola , Shakhnov Kirill 
Published: March 2022

Abstract
At a given point in time, bitcoin prices are different on exchanges located in different countries, or against different currencies. While existing literature attributes the largest price differences to frictions, like market segmentation, trading platforms advertize how to execute trades based on this information. We provide a novel risk-based explanation of these price differences for a sample containing the most reputable exchanges and after accounting for all transaction costs and limitations to trade. Bitcoin prices for more expensive pairs are riskier because they depreciate more in bad times for cryptocurrency investors, when aggregate liquidity and investor sentiment are lower. (JEL G12, G14, G15, F31).
Market Timing and Predictability in FX Markets
Authors: Maurer Thomas A , Tô Thuy-Duong , Tran Ngoc-Khanh 
Published: March 2022

Abstract
We study the economic value of market timing in foreign exchange (FX) markets, that is, using information about the conditional Sharpe ratio to adjust the notional value of a conditionally mean–variance efficient currency portfolio. Our strategy trades more (less) aggressively when the conditional risk-return trade-off is more (less) favorable. This leads to a significant improvement in the out-of-sample unconditional Sharpe ratio, skewness, and maximum drawdown per 1% expected excess return. The strategy’s market timing predicts returns, volatility, and skewness in FX markets. Popular currency pricing factors do not explain the strategy’s high average excess returns. Our findings suggest that it is costly to impose leverage or risk (i.e., conditional volatility) limits or other inferior market timing policies when constructing currency trading strategies.
How Does Open Access Publication Impact Readership and Citation Rates of Lumbar Spine Literature?
Authors: Lynch Conor P. , Cha Elliot D.K. , Patel Madhav R. , Jacob Kevin C. , Prabhu Michael C. , Pawlowski Hanna , Vanjani Nisheka N. , Singh Kern 
Published: March 2022

Study Design:
This was a retrospective review.

Objective:
The objective of this study was to assess the impact of open access (OA) publication on citation rates and attention scores of literature related to lumbar spine surgery.

Summary of Background Data:
OA literature allows readers to view full-text manuscripts of research publications free of charge, however, OA publication is often associated with substantial fees for authors.

Methods:
The Altmetric database was searched for articles related to lumbar spine surgery. Title, journal, publication date, Dimensions Citations, Mendeley Readers, Altmetric Attention Score (AAS), number of public mentions, and OA status were collected for each included article. The influence of OA status on Dimensions Citations, Mendeley Readers, and each individual component of the AAS was assessed. To control for journal influence, impact of OA on Dimensions Citations and AAS was separately assessed for each of the top 10 journals contributing the most mentioned articles. The top 25 most cited articles and top 25 articles by AAS were also characterized.

Results:
A total of 5245 articles were included, of which 2063 were published with OA and 3182 were not. OA status was a significant, independent predictor of AAS and Mendeley Readers (both P<0.001), but not Dimensions Citations (P=0.422). OA status significantly predicted mentions in news stories (P=0.003), Twitter posts (P<0.001), Facebook posts (P<0.001), and Wikipedia citations (P=0.011). Of the top 10 contributing journals, OA status significantly predicted Dimensions Citations for European Spine Journal, Journal of Neurosurgery: Spine, and Neurosurgery (P≤0.005) and predicted AAS for Spine, European Spine Journal, The Spine Journal, Journal of Neurosurgery: Spine, and Neurosurgery (P≤0.017, all).

Discussion:
OA status appeared to significantly impact public attention scores, but not citation rates, although these effects did vary based on the journal in which articles were published. Authors may want to consider OA publication based on their target audience and the goal of their research.
The role of genetic testing in prostate cancer screening, diagnosis, and treatment
Authors: de la Calle Claire M. , Bhanji Yasin , Pavlovich Christian P. , Isaacs William B. 
Published: March 2022

Purpose of review
This review provides an overview of the current role of genetic testing in prostate cancer screening, diagnosis, and treatment.

Recent findings
Recent studies have uncovered few but highly penetrant rare pathogenic mutations (RPMs), in genes, such as BRCA2, with strong prostate cancer risk and outcomes associations. Over 260 single nucleotide polymorphisms (SNPs) have also been identified, each associated with small incremental prostate cancer risk and when combined in a polygenic risk score (PRS), they provide strong prostate cancer risk prediction but do not seem to predict outcomes. Tumor tissue sequencing can also help identify actionable somatic mutations in many patients with advanced prostate cancer and inform on their risk of harboring a germline pathogenic mutation.

Summary
RPM testing, PRS testing, and tumor sequencing all have current and/or potential future roles in personalized prostate cancer care.
Robotic NICE Procedure Using Handsewn Technique
Authors: Haas Eric M. , Luna-Saracho Roberto , Rodriguez-Silva Jetsen A. , Ortiz De Elguea-Lizarraga Jose I. , LeFave Jean-Paul 
Published: March 2022

INTRODUCTION:
In 2018, we described a robotic natural orifice-assisted left-sided colorectal resection with intracorporeal anastomosis and transrectal extraction of the specimen and termed it the natural orifice intracorporeal anastomosis with transrectal extraction procedure. More recently, we have explored the feasibility, safety, and utility of performing total handsewn intracorporeal anastomosis. We present a technical video and initial experience depicting the unique steps to accomplish this procedure with colorectal end-to-end handsewn anastomosis.

TECHNIQUE:
Twenty natural orifice intracorporeal anastomosis with transrectal extraction procedures with end-to-end handsewn intracorporeal anastomosis were performed. A video depicting the essential steps with 2 variations of the handsewn techniques is presented along with short-term outcomes.

RESULTS:
The most common indication was complicated diverticulitis followed by rectal cancer and deep infiltrative endometriosis of the rectum. The mean operative time was 235 minutes (99–294 min), and there were no intraoperative complications or conversions. Handsewn end-to-end intracorporeal anastomosis was successful in all patients. Natural orifice transrectal extraction was successful in 17 of 20 (85%) patients. The mean postoperative length of stay was 2.1 days (±1.05 SD). There were 3 major complications. One patient developed a deep surgical site infection, and another patient had an organ space abscess. Both patients required readmission and were treated with antibiotics alone. One patient, who had a diverting ileostomy performed at the time of the index procedure, developed subclinical dehiscence of the anastomosis, which healed without intervention but resulted in a delay in ileostomy reversal. There were no additional readmissions and no reoperations or mortalities.

CONCLUSIONS:
Robotic natural orifice intracorporeal anastomosis with transrectal extraction procedure and colorectal end-to-end handsewn anastomosis was feasible and safe in this initial series. This technique can be successfully performed in a total intracorporeal manner without the need for an abdominal wall extraction incision or any circular stapling devices.
TWO CASES OF CRB1-RELATED RETINAL DYSTROPHY ASSOCIATED WITH RETINAL MASSES
Authors: Bello Nicholas R. , Pisuchpen Phattrawan , de Guimarães Thales A. C. , Capasso Jenina E. , Levin Alex V. 
Published: March 2022

Background/Purpose:
Mutations in CRB1 are associated with variable severity in expression leading to apparent phenotypic diversity. We present two retinal findings.

Methods:
We present two unrelated children with CRB1-related retinal dystrophy with a solitary mass visualized on fundoscopy. Both underwent a complete ophthalmologic examination including visual acuity assessment, optical coherence tomography, intravenous fluorescein angiography, and fundus autofluorescence.

Results:
In one child, a gliotic mass was observed on the superior temporal vessel away from disk. On optical coherence tomography, the mass appeared to be located in the superficial retina and contained discrete internal moth-eaten optically empty spaces as previously reported in the astrocytic hamartomas of tuberous sclerosis. Fundus autofluorescence showed speckled hyperautofluorescence of the lesion. In the other child, there was a calcified mass within the nerve fiber layer just temporal to the optic nerve. On optical coherence tomography, this mass appeared irregular in shape, encapsulated, and had a heterogeneous disorganized interior with hyperreflective areas.

Conclusion:
In this report, we detail two presentations of CRB1-related retinal dystrophy: retinal astrocytic hamartoma and another form of superficial retinal hamartoma. We believe this may represent a manifestation of CRB1 mutations. Recognition of this finding may prevent unnecessary evaluation for tumor cause in patients with CRB1-related retinal dystrophy.
Stellate nonhereditary idiopathic foveomacular retinoschisis and an approach to the differential diagnosis of macular star
Authors: Light Jacob G. , Pyfer Mark S. , Salabati Mirataollah , Mahmoudzadeh Raziyeh , Wakabayashi Taku , Ho Allen C. 
Published: March 2022

Purpose of review
This review aims to introduce stellate nonhereditary idiopathic foveomacular retinoschisis (SNIFR) and its differential diagnosis. We summarize findings from case reports and series published in the last few years on the clinical and imaging findings in SNIFR.

Recent findings
SNIFR presents as either a unilateral or bilateral macular star on fundus examination without clinical or imaging evidence of exudation or frank vitreomacular traction. optical coherence tomography (OCT) imaging shows schisis cavities in the Henle fibre and outer plexiform layers that correspond to the stellate en face findings. Visual acuity is usually minimally affected, and the presence of significant vision loss should prompt high clinical suspicion for alternate diagnoses.

Summary
SNIFR is a recently characterized clinical entity that serves as an important addition to the differential diagnosis of a macular star. It is a diagnosis of exclusion and should be distinguished from other causes of macular star such as neuroretinitis, vitreomacular traction, ocular manifestations of malignant hypertension, congenital juvenile X-linked macular schisis, myopic maculopathy, optic pit maculopathy, nicotinic acid maculopathy or taxane maculopathy among others.
The association between age at menarche and chronic pain outcomes in women: the Tromsø Study, 2007 to 2016
Authors: Lund Charlotte I. , Engdahl Bo , Rosseland Leiv A. , Stubhaug Audun , Grimnes Guri , Furberg Anne-Sofie , Steingrímsdóttir Ólöf A. , Nielsen Christopher S. 
Published: March 2022

Abstract
Sex differences in chronic pain are well established with documented predominance in women. This study assessed relationships between age at menarche and chronic pain, site-specific chronic pain, pain characteristics, and chronic widespread pain (CWP). We used data from the Tromsø Study conducted in 2007 to 2008 and 2015 to 2016 (Tromsø 6 and Tromsø 7 waves) including participants aged 30 to 99 years. The associations between age at menarche and chronic pain were examined in Tromsø 6 (n = 6449), Tromsø 7 (n = 5681), and the combination of Tromsø 6 and Tromsø 7 (n = 12,130). Tromsø 7 data were used further to examine the associations between age at menarche and site-specific chronic pain, 4 pain characteristics (pain duration, pain intensity, episode duration, and episode frequency), and CWP. All analyses were adjusted for body mass index, age, and economic status of the household in childhood. Lower age at menarche was associated with an increased risk of chronic pain in all 3 samples (risk ratio for each year delay in menarche 0.98, 95% CI [0.97 to 0.99] across samples). Risk differences were −0.014, CI 95% (−0.02 to −0.005) in Tromsø 6, −0.011, CI 95% (−0.02 to −0.02) in Tromsø 7, and −0.012, CI 95% (−0.02 to −0.01) in the combined sample. Age at menarche was significantly associated with chronic pain in the neck, abdomen, and both arms, and CWP. Of the 4 pain characteristics, pain duration was statistically significant. We conclude that early menarche is an independent risk factor for pain across a broad spectrum of pain outcomes.
Multisystem derangements in frailty and sarcopenia: a source for biomarker discovery
Authors: Picca Anna , Calvani Riccardo , Marzetti Emanuele 
Published: March 2022

Purpose of review
Multisystem derangements, encompassing metabolic, musculoskeletal and stress-response systems, occur during aging and are associated with the development of physical frailty and sarcopenia. These modular changes are relevant sources for the identification of biomarkers for the two conditions. Here, we provide an up-to-date overview on existing biomarkers of physical frailty and sarcopenia and discuss emerging approaches for biomarker discovery.

Recent findings
Inflammatory, metabolic and hematologic markers are shared between physical frailty and sarcopenia. Gut microbial derivatives and damage-associated molecular patterns transferred via extracellular vesicles have been indicated as possible gut-muscle axis regulators and candidate markers of physical frailty and sarcopenia.

Summary
Mediators of metabolic, musculoskeletal and stress-response system dysregulation are shared by physical frailty and sarcopenia and indicate the existence of common pathophysiological pathways. Multiplatform biomarker analyses have been proposed as an innovating approach for tracking the multifaceted and dynamic nature of physical frailty and sarcopenia. Upon validation, the identified biomarkers may support diagnostic makeup and tracking of the two conditions in both research and clinical settings.