bluuebunny/crossref_metadata_2025_split huggingface dataset:
Predicting sentiment analysis for Web users with a deep learning approach
Authors: Abdelwahed Nawres , Letaifa Asma Ben , Asmi Sadok El , Ksouri Azer 
Published: April 2022

Abstract
In the last decade Sentiment analysis has been an interesting research topic in natural languageprocessing (NLP) and data mining fields. We have noticed that deep neural network (DNN)models are always applied in sentiment analysis researches to obtain good results. There aremany neural architectures which are applied for sentiment analysis. Among these architectures,Long Short-Term Memory (LSTM) models are the most used ones. In this contribution, we collectedour dataset from our developed web application. The obtained dataset contains differenttypes of features; Quality of Service (QoS) metrics, Web Quality of Experience (QoE) metrics,user engagement metrics, comments to videos that are included in the application, and the MeanOpinion Score (MOS) expressed by users. After that, we trained our dataset on our proposedmodel LSTM-CNN-RNN to predict the MOS. As a conclusion, we obtained a good accuracyand a low loss rate.
G-quadruplex Binding Protein Developed using the RGG Domain in TLS/FUS Inhibits Transcription of c-myc
Authors: Ulum Luthfi Lulul , Yagi Ryota , Kawashima Tomoe , Oyoshi Takanori 
Published: April 2022

Abstract
The G-quadruplex structure in the genome is an important drug target because it regulates gene expression and the genome structure. Several small molecules that bind the G-quadruplex have been developed, but few artificial G-quadruplex binding proteins have been reported. We previously reported a novel G-quadruplex DNA binding protein (RGGF) engineered using the Arg-Gly-Gly repeat (RGG) domain of TLS (translocated in liposarcoma). Here we show that RGGF recognizes DNA loops in the G-quadruplex and preferentially binds G-quadruplex DNA with long loops. Furthermore, RGGF binds to G-quadruplex DNA of the c-myc promoter in vitro and represses c-myc transcription in vivo. On the basis of these findings, G-quadruplex binding protein engineered from the RGG domain will be useful for investigating G-quadruplex transcriptional function in the genome.
Recent Advances in Acid-sensitive Ion Channels in Central Nervous System Diseases
Authors: Zhu Yueqin , Hu Xiaojie , Wang Lili , Zhang Jin , Pan Xuesheng , Li Yangyang , Cao Rui , Li Bowen , Lin Huimin , Wang Yanan , Zuo Longquan , Huang Yan 
Published: April 2022

Abstract:Acid-sensitive ion channels (ASICs) are cationic channels activated by extracellular protons and widely distributed in the nervous system of mammals. It belongs to the ENaC/DEG family and has four coding genes: ASIC1, ASIC2, ASIC3, and ASIC4, which encode eight subunit proteins: ASIC1a, ASIC1b, ASIC1b2, ASIC2a, ASIC2b, ASIC3, ASIC4, and ASIC5. Different subtypes of ASICs have different distributions in the central nervous system, and they play an important role in various physiological and pathological processes of the central nervous system, including synaptic plasticity, anxiety disorders, fear conditioning, depressionrelated behavior, epilepsy, Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, multiple sclerosis, malignant Glioma, pain, and others. This paper reviewed the recent studies of ASICs on the central nervous system to improve the understanding of ASICs’ physiological functions and pathological effects. This article also references studying the molecular mechanisms and therapeutic measures of nervous system-related diseases.
The Advances and Challenges in Enzymatic C-glycosylation of Flavonoids in Plants
Authors: Gao Hui-Yao , Liu Yan , Tan Fei-Fan , Zhu Li-Wen , Jia Kai-Zhi , Tang Ya-Jie 
Published: April 2022

Abstract:
Flavonoid glycosides play determinant roles in plants and have considerable potential for applications
in medicine and biotechnology. Glycosyltransferases transfer a sugar moiety from uridine diphosphateactivated
sugar molecules to an acceptor flavonoid via C-O and C-C linkages. Compared with O-glycosyl flavonoids,
C-glycosyl flavonoids are more stable, resistant to glycosidase or acid hydrolysis, exhibit better pharmacological
properties, and have received more attention. In this study, we discuss the mining of C-glycosyl
flavones and the corresponding C-glycosyltransferases and evaluate the differences in structure and catalytic
mechanisms between C-glycosyltransferase and O-glycosyltransferase. We conclude that promiscuity and specificity
are key determinants for general flavonoid C-glycosyltransferase engineering and summarize the
C-glycosyltransferase engineering strategy. A thorough understanding of the properties, catalytic mechanisms,
and engineering of C-glycosyltransferases will be critical for future biotechnological applications in areas such
as the production of desired C-glycosyl flavonoids for nutritional or medicinal use.
Flavonoids as Sirtuin Modulators
Authors: Deniz Fatma Sezer Şenol , Eren Gökçen , Orhan Ilkay Erdogan 
Published: April 2022

Abstract:
Sirtuins (SIRTs) are described as NAD+-dependent deacetylases, also known as class III histone deacetylases. So far, seven sirtuin genes (SIRTS 1–7) have been identified and characterized in mammals and also known to occur in bacteria and eukaryotes. SIRTs are involved in various biological processes including endocrine system, apoptosis, aging and longevity, diabetes, rheumatoid arthritis, obesity, inflammation, etc. Among them, the best characterized one is SIRT1. Actually, small molecules seem to be the most effective SIRT modulators. Flavonoids have been reported to possess many positive effects favrable for human health, while a relatively less research has been reported so far on their funcions as SIRT modulation mechanisms. In this regard, we herein aimed to focus on modulatory effects of flavonoids on SIRTs as the most common secondary metabolites in natural products. Our literature survey covering the years of 2006-2021 pointed out that flavonoids frequently interact with SIRT1 and SIRT3 followed by SIRT6. It can be also concluded that some popular flavonoid derivatives, e.g. resveratrol, quercetin, and catechin derivatives came forward in terms of SIRT modulation.
MicroRNAs as a Novel Player for Differentiation of Mesenchymal Stem
Cells into Cardiomyocytes
Authors: Azizidoost Shirin , Farzaneh Maryam 
Published: April 2022

Abstract:
Cardiovascular disease (CVD) is defined as a class of disorders affecting the heart and blood
vessels. Cardiomyocytes and endothelial cells play important roles in cardiac regeneration and heart repair.
However, the proliferating capacity of cardiomyocytes is limited. To overcome this issue, mesenchymal
stem cells (MSCs) have emerged as an alternative strategy for CVD therapy. MSCs can proliferate
and differentiate (or trans-differentiate) into cardiomyocytes. Several in vitro and in vivo differentiation
protocols have been used to obtain MSCs-derived cardiomyocytes. It was recently investigated that
microRNAs (miRNAs) by targeting several signaling pathways, including STAT3, Wnt/β-catenin, Notch,
and TBX5, play a crucial role in regulating cardiomyocytes' differentiation of MSCs. In this review, we
focused on the role of miRNAs in the differentiation of MSCs into cardiomyocytes.
The Emergence of Omicron SARS-CoV-2 Variant (B.1.1.529): The Latest
Episode in the COVID-19 Pandemic with a Global Riposte
Authors: Ray Suman Kumar , Mukherjee Sukhes 
Published: April 2022

Abstract:
Over two years after the start of the SARS-CoV-2 epidemic, which has demised over 5 million
people, the world is still on high COVID-19 alert in February 2022, and new variants are emerging.
Since January 2020, the World Health Organization (WHO) has been closely monitoring and analyzing
the evolution of SARS-CoV-2 in partnership with national authorities, public health organizations,
and scientists. To prioritize global monitoring and research and to guide the continuing global
response to the COVID-19 pandemic, distinct SARS-CoV-2 variants were labelled as Variant of Interest
(VOI) and Variant of Concern (VOC). The World Health Organization and its international sequencing
networks are constantly monitoring SARS-CoV-2 mutations and informing countries about
any adjustments that may be required to respond to the variant and, where possible, prevent its spread.
Since January 2021, multiple viral variations have evolved and grown dominant in numerous countries,
with the Alpha, Beta, Gamma, and Delta varieties being the most prevalent too far. On November 20,
2021, Omicron was born into a COVID-19-weary world, replete with rage and resentment at the pandemic's
broad detrimental effects on social, emotional, and economic well-being. Although earlier
VOCs originated in a world where natural immunity to COVID-19 infections was widespread, the fifth
VOC, Omicron, has emerged in an environment where vaccine immunity is rising.
Natural Products as Bioactive Agents in the Prevention of Dementia
Authors: Rasool Mahmood , Ullah Hamid , Hussain Abrar , Asif Muhammad , Nawaz Faheem 
Published: April 2022

Abstract:
Dementia is a complex syndrome of neurological disorders which is associated with cognitive
functions of the body. The present review focuses on the role and application of natural products
in the treatment of dementia and related diseases. The studies highlight that there exist some potent
synthetic/semisynthetic drugs that can effectively target dementia and related diseases. In contrast, despite
the existence of a large library of natural products, only a few of them (galantamine, huperzine
A, etc.) have been approved as drugs against dementia. This fact is not discouraging because a large
number of natural products, including classes of polyphenols, alkaloids, isothiocyanates, phytocannabinoids,
and terpenoids, are in the process of drug development stages against dementia and related
diseases. It is because they display some promising and diverse biological activities, including antioxidant,
acetylcholinesterase inhibitory activity, and anti-amyloidogenic properties, which are significantly
associated with the prevention of dementia syndrome. The studies reported in the literature reveal
that bioactive natural products particularly target Alzheimer’s and Parkinson’s diseases by suppressing
the risks responsible for dementia. Huperzine A has been identified as a potent natural product
against Alzheimer’s disease. Despite the efficient role of natural products in preventing dementia,
their direct application as drugs is still limited due to some controversial results obtained from their
clinical trials; however, bioassay-guided drug development studies can prove them potential drugs
against dementia and related diseases. This review provides useful information for researchers, pharmacologists,
and medical doctors.
Marine Biomaterials for Pharmaceutical Applications: A Review
Authors: Murti Yogesh , Semwal Bhupesh Chander , Singh Sonia 
Published: April 2022

Background:
Marine ecosystem is one of the main natural sources of numerous biologically active components along with rich biodiversity. Marine biomaterials obtained from fungi, algae, bacteria, and fish, are considered promising candidates for providing various biological as well as biomedical application(s).

Objective:
The main focused objective of this manuscript is to take out the recent trends utilized in several marine-based biomaterials developed for pharmaceutical applications.

Method:
The literature contains valuable and collective information on the different bioactivities of marine-based biomaterials. A total of 287 articles are cited in the present review covering a broad spectrum of marine biomaterials, and their pharmaceutical importance. Information of different marine biomaterials along with their source, chemical nature, and pharmaceutical importance are exhaustively compiled here.

Results:
Marine-based biomaterials possess a wide range of physiochemical activities and modifications in these properties can also enhance the therapeutic and regenerative capacity. Marine biomaterials have proven a good source for the development of different areas of the pharmaceutical field and still, the application of marine biomaterials is going through revitalization in the biomedical field.

Conclusion:
Due to the amazing diversity involved in marine life, there would be more significant and remarked discoveries developed in the field of marine biomaterials in respect of future implementation in the pharmaceutical arena.
Effectiveness of Web-Based Personalized Nutrition Advice for Adults Using the eNutri Web App: Evidence From the EatWellUK Randomized Controlled Trial
Authors: Zenun Franco Rodrigo , Fallaize Rosalind , Weech Michelle , Hwang Faustina , Lovegrove Julie A 
Published: April 2022

Background
Evidence suggests that eating behaviors and adherence to dietary guidelines can be improved using nutrition-related apps. Apps delivering personalized nutrition (PN) advice to users can provide individual support at scale with relatively low cost.

Objective
This study aims to investigate the effectiveness of a mobile web app (eNutri) that delivers automated PN advice for improving diet quality, relative to general population food-based dietary guidelines.

Methods
Nondiseased UK adults (aged >18 years) were randomized to PN advice or control advice (population-based healthy eating guidelines) in a 12-week controlled, parallel, single-blinded dietary intervention, which was delivered on the web. Dietary intake was assessed using the eNutri Food Frequency Questionnaire (FFQ). An 11-item US modified Alternative Healthy Eating Index (m-AHEI), which aligned with UK dietary and nutritional recommendations, was used to derive the automated PN advice. The primary outcome was a change in diet quality (m-AHEI) at 12 weeks. Participant surveys evaluated the PN report (week 12) and longer-term impact of the PN advice (mean 5.9, SD 0.65 months, after completion of the study).

Results
Following the baseline FFQ, 210 participants completed at least 1 additional FFQ, and 23 outliers were excluded for unfeasible dietary intakes. The mean interval between FFQs was 10.8 weeks. A total of 96 participants were included in the PN group (mean age 43.5, SD 15.9 years; mean BMI 24.8, SD 4.4 kg/m2) and 91 in the control group (mean age 42.8, SD 14.0 years; mean BMI 24.2, SD 4.4 kg/m2). Compared with that in the control group, the overall m-AHEI score increased by 3.5 out of 100 (95% CI 1.19-5.78) in the PN group, which was equivalent to an increase of 6.1% (P=.003). Specifically, the m-AHEI components nuts and legumes and red and processed meat showed significant improvements in the PN group (P=.04). At follow-up, 64% (27/42) of PN participants agreed that, compared with baseline, they were still following some (any) of the advice received and 31% (13/42) were still motivated to improve their diet.

Conclusions
These findings suggest that the eNutri app is an effective web-based tool for the automated delivery of PN advice. Furthermore, eNutri was demonstrated to improve short-term diet quality and increase engagement in healthy eating behaviors in UK adults, as compared with population-based healthy eating guidelines. This work represents an important landmark in the field of automatically delivered web-based personalized dietary interventions.

Trial Registration
ClinicalTrials.gov NCT03250858; https://clinicaltrials.gov/ct2/show/NCT03250858
Korelasi Kecerdasan Emosional dan Spiritual dengan Pengetahuan Hadis pada Mahasiswa Prodi IAT UIN Ar-Raniry Banda Aceh
Authors: Masyithah Siti Hajril , Maizuddin Maizuddin , Nurkhalis Nurkhalis 
Published: April 2022

This paper aims to determine the relationship between emotional intelligence and spiritual intelligence with knowledge of hadith about Islam, faith and ihsan in students of the Qur'an and Tafsir Study Program, Faculty of Ushuluddin and Philosophy (IAT FUF) UIN Ar-Raniry Banda Aceh. This research is quantitative with the type of correlation research. Based on the results of the study, shows: first, there is a positive and significant relationship between emotional intelligence and spiritual intelligence with the results of hadith knowledge about Islam, faith and ihsan in students of IAT FUF UIN Ar-Raniry Banda Aceh Study Program. The correlation between emotional intelligence and spiritual intelligence is directly proportional to hadith knowledge. With a correlation coefficient level of 0.65 in the strong category with a coefficient of determination (D) = 42%, the higher the level of knowledge of hadith about Islam, faith and ihsan among students, the higher the level of emotional intelligence and spiritual intelligence possessed by students the. Second, practical knowledge of hadith about Islam, faith and ihsan encourages students to motivate themselves, control emotions in social interactions and interpret the learning process as worship. Tulisan ini bertujuan untuk mengetahui hubungan kecerdasan emosional dan kecerdasan spiritual dengan pengetahuan hadis tentang Islam, iman dan ihsan pada mahasiswa Prodi Ilmu Alquran dan Tafsir Fakultas Ushuluddin dan Filsafat (IAT FUF) UIN Ar-Raniry Banda Aceh. Penelitian ini bersifat kuantitatif dengan jenis penelitian korelasi. Berdasarkan hasil penelitian menunjukkan: pertama, terdapat hubungan yang positif dan signifikan antara kecerdasan emosional dan kecerdasan spiritual dengan hasil pengetahuan hadis tentang Islam, iman dan ihsan pada mahasiswa Prodi IAT FUF UIN Ar-Raniry Banda Aceh. Korelasi antara kecerdasan emosional dan kecerdasan spiritual berbanding lurus dengan pengetahuan hadis. Dengan tingkat koefisien korelasi sebesar 0,65 pada kategori kuat dengan koefisien determinasi (D) = 42%, semakin tinggi tingkat pengetahuan hadis tentang Islam, iman dan ihsan di kalangan mahasiswa, maka semakin tinggi pula tingkat kecerdasan emosional dan kecerdasan spiritual yang dimiliki oleh mahasiswa tersebut. Kedua, secara praktis pengetahuan hadis tentang Islam, iman dan ihsan mendorong mahasiswa untuk memotivasi diri, mengendalikan emosi dalam interaksi sosial dan memaknai proses pembelajarannya sebagai ibadah.
The impact of the banking sector on economic growth in Poland ? an econometric analysis
Authors: Bukowski Sławomir Ireneusz , Kraczkowski Maks 
Published: April 2022

The paper analyses the impact of the banking sector on economic growth in Poland. The aim of the paper was to analyse if the banking sector has a significant effect on economic growth in the case of Poland. Hence, the following hypothesis was formulated: there is a statistically significant relation between the development of the banking sector and economic growth in Poland. On the basis of the applied econometric methods, it has been possible to demonstrate that the banking sector?s development has an economically and statistically significant impact on economic growth in Poland.
Makerspace e biblioterapia em hospitais: um estudo bibliométrico
Authors: Silva Rafaela Carolina , Souza Leonardo Pereira Pinheiro , Mello Mariana Rodrigues Gomes , Santos Fernanda Bochi , Moraes Cássia Regina Bassan 
Published: April 2022

No mundo contemporâneo, pressões de ordem informacional, social, econômica, entre outras, incidem sobre os indivíduos em sociedade, propiciando a proliferação de doenças mentais. Nesse cenário, estratégias de complemento às terapias psicológicas/psiquiátricas convencionais passaram a ser levadas em conta no trabalho com a saúde mental em hospitais. Dentre elas, duas contam com a participação do profissional de informação, ou seja, a biblioterapia, que proporciona uma auto-reflexão por meio de livros; e o espaço maker, no qual o sujeito pode criar objetos, expressando-se e exercitando a sua criatividade. Isto posto, esta pesquisa objetivou verificar o volume do corpus de artigos que tratam da interação entre ciência da informação, espaço maker e biblioterapia em hospitais que trabalham com saúde mental, destacando como as palavras-chave utilizadas ajudam a entender essa relação. Ademais, buscou-se verificar como se dá a prática da biblioterapia e do espaço maker em bibliotecas brasileiras. Como procedimentos metodológicos, usou-se a análise de co-ocorrência de palavras-chave, além do emprego de questionário online com bibliotecários de diversos estados brasileiros. Apurou-se que o corpus de trabalhos é ainda incipiente, com oito grupos de artigos, constando 105 palavras-chave. O estudo empírico demonstrou que ainda não está consolidada a prática do makerspace em bibliotecas. Contudo, essas instituições contribuem para a saúde mental dos seus usuários, por meio de seus acervos e do encaminhamento de indivíduos a profissionais especializados.
THE INTEGRATION OF CHESS AND MATHEMATICS AS A PREREQUISITE FOR ENHANCING THE QUALITY OF EDUCATION
Authors: Hovhannisyan Knarik , Misakyan Samvel , Sargsyan Vahan , Muradyan Rima 
Published: April 2022

ABSTRACT
Numerous studies have proven that chess indicates a player's mental skills and ability to think. The goal of our study is to explore the process of learning chess in elementary school in the context of the integration of mathematics and chess, as well as to develop and offer methodological suggestions that will improve the efficiency of understanding mathematics. By solving non-standard "chess" problems in math classes and extracurricular math lessons, the link between chess and the development of spatial thinking can help to foster the development of a unique capacity to operate in the mind.
Abordagem atualizada da Lesão Renal Aguda (LRA): uma revisão narrativa
Authors: Pacheco Livio Pereira , Pereira Ana Clara Verônica , Silva Ana Dávila Carneiro da , Brock Diana Pádua Prates , Abreu Fabricia Mendes dos Santos , Silva Laís Eunice de Assis , Andrade Letícia Macedo Nicácio , Tissi Lígia Soares , Carneiro Yan Vasconcelos , Miura Felipe Kazuyoshi 
Published: April 2022

Objetivo: Esclarecer informações sobre Lesão Renal Aguda (LRA) e contribuir com a literatura médica. Revisão bibliográfica: A LRA é um declínio rápido da função renal ao longo de dias a semanas, resultando no acúmulo de produtos nitrogenados no sangue (azotemia), com ou sem diminuição do débito urinário. Geralmente é causada por hipoperfusão dos rins devido a trauma grave, doença ou cirurgia, mas em alguns casos é causada por doença renal intrínseca rapidamente progressiva. Os sintomas podem incluir anorexia, náuseas e vômitos. Se não for tratada, convulsões e coma podem ocorrer. Desequilíbrios de fluidos, eletrólitos e ácido-base se desenvolvem rapidamente. O diagnóstico é baseado em exames laboratoriais de função renal, incluindo creatinina sérica. Marcadores de urina, teste de sedimento urinário, exames de imagem e outros são necessários para determinar a causa. O tratamento é específico para a causa, mas também pode ser realizado pela restauração do equilíbrio hídrico e eletrolítico e, às vezes, pela diálise. Considerações finais: A LRA tem etiofisiopatologia ligada à doença base do paciente e sempre foi um desafio para os médicos devido à variedade de suas etiologias, apresentações clínicas e complicações, devendo ser precisamente identificada para conduta precoce.