bluuebunny/crossref_metadata_2025_split huggingface dataset:
Rolling origami of vanadium dioxide nanomembranes for enhanced multi-level solar modulation
Authors: Li Xing , Cao Cuicui , Liu Chang , He Wenhao , Wu Kaibo , Wang Yang , Xu Borui , Tian Ziao , Song Enming , Cui Jizhai , Huang Gaoshan , Zheng Changlin , Di Zengfeng , Cao Xun , Mei Yongfeng 
Published: July 2022

Abstract
Thermochromic window develops as a competitive solution for carbon emissions due to comprehensive advantages of its passivity and effective utilization of energy. How to further enhance the solar modulation (ΔTsol) of thermochromic windows while ensuring high luminous transmittance (Tlum) becomes the latest challenge to touch the limit of energy efficiency. Here, we demonstrated rolling origami of vanadium dioxide (VO2) nanomembranes (NMs), and designed a smart window (SW) combining mechanochromism with thermochromism to enhance multi-level solar modulation. The mechanochromism is applied by the temperature-controlled regulation of rolled-up SWs in a wide range of radiation, which benefits from effective strain adjustment in VO2 NMs upon the phase transition. Under geometry design and optimization, the rolled-up SW with high ΔTsol (42.41%) and Tlum (61.01%) is achieved for the modulation of indoor temperature self-adapted to seasons. Furthermore, such rolled-up SW enables high infrared reflectance after triggered phase transition and acts as a smart lens protective cover for high power radiation, which can remain high transmittance under normal operation. This work supports the feasibility and superiority of rolling origami technology in SWs and lens protection, which promises broad interest and practical applications of self-adapting devices and systems for smart building, intelligent sensors, and actuators with the perspective of energy efficiency.
Outcomes of total hip arthroplasty with a standard prosthesis for the affected hip in patients with poliomyelitis sequela: A mid-term retrospective follow-up study
Authors: Shi lihan , Che Guangwei , Huang Yong , Yi Min , Kang Pengde 
Published: July 2022

Abstract
Introduction: Total hip arthroplasty for poliomyelitis sequelae could be a technical challenge due to the higher risk for prosthetic dislocation and degenerative changes in the affected limbs. This study aimed to analyse the mid-term outcomes of primary total hip arthroplasty on the affected hip with standard prosthesis.Materials and Methods: From January 2008 to January 2018, 32 patients with poliomyelitis sequela underwent total hip arthroplasty on the affected hip with standard prosthesis. Clinical and radiographical outcomes, complications, and prosthesis survival rates were evaluated.Results: After a mean follow-up of 6.3 (2.8–11.5) years, the Harris Hip Score, University of California Los Angeles activity level rating, and 12-item Short Form Health Survey Questionnaire scale score significantly improved. The abduction and flexion motions of the hip joint improved dramatically, and the visual analogue scale pain score decreased significantly.The leg length discrepancy was effectively corrected. During the follow-up, one patient experienced prosthetic dislocation, one underwent revision surgery due to acetabular component loosening, two had osteolysis, four had heterotopic ossification, two experienced transient sciatic nerve palsy, and one had intermuscular vein thrombosis. The prosthesis survival rate was 95.7%, at 4.5 years postoperatively.No periprosthetic infection occurred.Conclusion: Total hip arthroplasty with standard prosthesis could be an effective treatment for hip arthropathy on the affected hip of patients with poliomyelitis sequela, resulting in good clinical outcomes and few complications. Constrained liner and dual mobility articulation are not recommended unless the hip muscle strength of the abductor is < III.
N-acetyl cysteine: A new look at its effect on PTZ-induced convulsions
Authors: Egilmez Cansu Bilister , Pazarlar Burcu Azak , Erdogan Mumin Alper , Erbas Oytun 
Published: July 2022

Abstract
Introduction /Aim:
Epilepsy is still widely investigated as a common neurological disease requiring pharmacologically effective agents. N-acetyl cysteine (NAC), the acetyl derivative of cysteine, has become a remarkable molecule with its role in both antioxidant and glutaminergic modulation. There are many points and processes waiting to be revealed regarding the role of NAC in epilepsy.
Materials and Methods
In this study, pentylenetetrazole (PTZ) was administrated to induce seizures. 30 minutes before the seizure-induced procedure, N-acetyl cysteine (NAC) was administered by intraperitoneally at doses of 300 and 600 mg/kg as pretreatment. There are 2 groups designed independently of each other with PTZ doses applied at different doses. These groups were formed in such a way that we evaluated the spike percentage with electroencephalography following 35 mg/kg PTZ, and behavioral observation following 70 mg/kg PTZ. As a biochemical analysis, malondialdehyde (MDA) which is an indicator of lipid peroxidation, was evaluated and superoxide dismutase (SOD) enzyme level was analyzed.
Results
There was a dose-dependent reduction in seizure stage and prolonged onset time of the first myoclonic jerk in rats with N-acetylcysteine pretreatment. EEG recordings resulted in a dose-dependent decrease in spike percentages. Both doses improved MDA and SOD levels, further the results indicate that the higher dose of NAC (600 mg/kg) was more effective.
Conclusion
In the light of all our findings, we can report that N-acetyl cysteine has been shown to be promising with its reducing effect on convulsions. In line with these results, it is obvious that it has a beneficial effect by preventing oxidative stress. Detailed and comparative studies are needed on the convulsion-reducing effect of N acetyl cysteine in epilepsy.
Association of Chronic Kidney Disease with Prior Tinnitus: A Case-Control Study
Authors: Hung Shih-Han , Xirasagar Sudha , Cheng Yen-Fu , Kuo Nai-Wen , Lin Herng-Ching 
Published: July 2022

Abstract
This study aims to explore the relationship between prior tinnitus and the occurrence of chronic kidney disease (CKD) using a nationwide, population-based case-control study. We used data from the Taiwan National Health Insurance Research Database to explore the association of CKD with tinnitus. We identified 15,314 patients aged ≥ 40 years old with a first-time diagnosis of CKD as cases. We used propensity-scored matching to select 45,942 controls (1:3 ratio). We performed multivariate logistic regression to estimate the odds ratio (OR) of a prior tinnitus diagnosis among the CKD group vs control group. Analysis showed that 770 (1.26%) out of the 61,256 sampled patients had previously diagnosed tinnitus. Chi-square test revealed a significant difference in the rate of previously diagnosed tinnitus between cases and controls (3.86% vs. 0.93%, p<0.001). Univariate logistic regression analysis showed an OR of prior tinnitus for cases of 10.249 (95% confidence interval [CI]: (8.662 ~ 12.126)) relative to controls. In adjsuted analysis, cases were more likely than controls to have a prior diagnosis of tinnitus (OR=10.970, 95% CI=9.255 ~ 13.004, p<0.001) after adjusting for age, sex, monthly income, geographic location, urbanization level, hypertension, diabetes, coronary heart disease, hyperlipidemia, obesity and autoimmune disease. Our study shows that persons with tinnitus are at higher risk of a subsequent diagnosis of CKD. Patients diagnosed with tinnitus may benefit from proactive measures to prevent CKD and detect it early through lifestyle modifications and regular renal function examinations regardless of CKD-related symptoms.
Wnt/PCP-YAP-BIRC2 axis maintains cartilage stem/progenitor cell homeostasis in osteoarthritis
Authors: Zhang Lina , Wang Xinxing , Xia Guang , Huang Junjie , Wen Zi , Liang Chi , Cao Xu , Wu Song 
Published: July 2022

Abstract
Background
The cartilage stem/progenitor cells (CSPCs) play a critical role in maintaining cartilage homeostasis. However, the regulation of CSPC function in the microenvironment of Osteoarthritis (OA) is not fully understood.
Methods
The joint fluid of 10 OA patients were collected and analyzed for WNT signaling. CSPCs derived from these patients were isolated, identified, and evaluated for cellular functions. The effect of non-canonical WNT signaling and Yes-associated protein (YAP) expression on CSPCs was investigated in vitro. The OA rat model was established by Hulth’s method. Lentivirus-mediated YAP (Lv-YAP) or lentivirus-mediated YAP RNAi (Lv-YAP-RNAi) was injected intra-articularly to modulate YAP expression in rat joint. In addition, allogeneic CSPCs overexpressing or silencing YAP were transplanted by intra-articularly injection. We also evaluated the functions of CSPC and the OA-related cartilage phenotype in the rat model. Finally, the transcriptome of OA-CSPCs overexpressing YAP was examined to explore the downstream targets of YAP in CSPC.
Results
OA-CSPCs exhibited impaired function in the microenvironment dominated by Wnt/β-catenin signaling and activated function in Wnt/PCP signaling. Wnt5A/B improved the proliferative activity and migration ability of OA-CSPCs. In OA-CSPCs, Wnt/PCP signaling upregulated YAP, which maintained the homeostasis and functions of CSPCs. Upregulation of YAP in the joint delayed OA progression and improved the cartilage regeneration capacity of CSPCs. Using transcriptomic analysis, we found that YAP regulates CSPC function by upregulating Baculoviral IAP repeat-containing 2 (BIRC2). Furthermore, knockdown of BIRC2 significantly impaired the cellular functions of CSPCs and largely blocked the regulation of YAP on CSPCs.
Conclusion
In this study, dysregulation of the Wnt/PCP-YAP-BIRC2 signaling axis contributes to OA-CSPC dysfunction, impairs cartilage's intrinsic reparative ability and accelerates OA progression. This provides a potential therapeutic target for OA.
Successful induction of artificial lactation in non-pregnant gilts
Authors: Cordeiro Ágatha Decroix , Conterato Ana Júlia , Bianchi Ivan , Dartora Débora Lis , Zanella Ricardo , Marques Mariana Groke , Gasperin Bernardo , Lucia Thomaz 
Published: July 2022

Abstract
The increase in litter resulted in increased demand for milk in farrowing rooms to improve piglet survival. This study tested a protocol for induction of artificial lactation (AL) in non-pregnant gilts as a mean to supply milk to newborn piglets. In Experiment I, five gilts received 10 mg estradiol cypionate (EC) on the last day of estrus expression (D0), 10 mg EC and 300 mg long-acting progesterone (P4) on D26, and two doses of a prostaglandin F2α analogue (PGF) I.M. on D36 (0.53 mg each, 12 h apart). Blood was collected on D12, D19, D26 and D33. Milk secretion occurred in all treated gilts 24 h after the PGF administration, lasting at least 8 d. Milk samples were collected from D37 to D45. The circulatory P4 concentration was lower on D12 than subsequently (P < 0.05), but the estradiol concentration did not differ (P > 0.05). The milk produced during the AL was generally richer in protein and poorer in fat than the milk produced during the lactation of a control sow, but both concentrations were only altered near to the 3rd d of the AL. In Experiment II, the same protocol for induction of AL was administered to two gilts. After milk secretion started, each gilt received four 5-d old piglets fostered from other litters. The piglets were nursed for 22 d and weaned weighing approximately 5 kg. Considering both experiments, AL was induced in all treated gilts and the milk produced was capable to nurture fostered piglets.
Improved outcome of adult T-cell leukemia-lymphoma with cord blood transplantation: a nationwide retrospective study
Authors: Tokunaga Masahito , Nakano Nobuaki , Fuji Shigeo , Wake Atsushi , Utsunomiya Atae , Ito Ayumu , Eto Tetsuya , Kawakita Toshiro , Mori Yasuo , Moriuchi Yukiyoshi , Suehiro Youko , Miyazaki Yasuhiko , Uchida Naoyuki , Sawayama Yasushi , Ishitsuka Kenji , Kanda Junya , Kimura Takafumi , Ichinohe Tatsuo , Atsuta Yoshiko , Fukuda Takahiro , Yoshimitsu Makoto , Kato Koji 
Published: July 2022

Abstract
We examined 1495 patients with adult T-cell leukemia-lymphoma (ATL) who underwent their first allogeneic hematopoietic cell transplantation (HCT) in 2008–2017. We evaluated cord blood (CB) transplantation (CBT) outcomes in two groups, 2008–2012 and 2013–2017, using a propensity score-matched (PSM) analysis. The median age at HCT was 61 years in patients who received CBT in 2013–2017. After PSM analysis, CBT patients in 2008–2012 had high transplantation-related mortality (TRM) (2-year TRM: 45.6%) and poor overall survival (OS) (2-year OS: 30.2%). In 2013–2017, 2-year OS (28.0% vs. 35.7%, respectively; P = 0.273), 2-year ATL-related mortality (35.7% vs. 30.7%, respectively; P = 0.377), and 2-year TRM (36.4% vs. 33.5%, respectively; P = 0.806) were comparable between patients with CBT and those with HCT from other donor sources. We found more anti-human leukocyte antigen antibody testing, infused CB total nucleated cells, and patients achieving neutrophil engraftment as well as fewer infectious disease deaths among CBT patients in 2013–2017 than in 2008–2012, which may have contributed to the decrease in TRM. In conclusion, OS and TRM following CBT improved despite the advanced age of ATL patients, and CB is now a reasonable alternative donor source for ATL.
Highly efficient glycerol acetalization to solketal over Keggin type heteropolyacid supported on ionic liquid decorated hierarchical faujasite zeolite, prepared through a novel approach
Authors: Tarighi Sara , Sadjadi Samahe , Delangiz Motahareh 
Published: July 2022

Abstract
To handle huge amount of glycerol produced in biodiesel industry, glycerol is transformed to value-added products. In this regard, glycerol acetalization to solketal is industrially attractive. As in this process various by-products can be formed, designing highly selective catalysts is of great importance. In this line, we wish to report a novel catalyst that benefits from strong acidity, high specific surface area and thermal stability, which can selectively form solketal in glycerol acetalization. To prepare the catalyst, hierarchical zeolite was prepared via a novel method, in which partially delaminated NaY was treated with Pluronic®F-127 and then reacted with NH4NO3 to furnish the H-form zeolite. Hierarchical faujasite was then achieved through calcination and template removal. Subsequently, it was functionalized with ionic liquid and used for the immobilization of heteropolyacid. The results indicated the importance of the mesoprosity of zeolite and the presense of ionic liquid functionality for achiveing high solketal yield. Moreover, among three investigated heteropolyacids, phosphomolybdic acid exhibited the highest catalytic activity. In fact, using 10 wt.% catalyst at 55°C and glycerol to acetone molar ratio of 1: 20, solketal with yield of 98% was furnished under solvent-less condition. Besides, the catalyst was recyclable with low leaching of heteropolyacid.
Oncogenic role of a long-term high-fat diet-induced DNM1 in hepatocellular carcinoma
Authors: Wu Hsing-Ju , Chou Dev-Aur , Chen Po-Ming , Chu Pei-Yi , Tang Feng-Yao , Chiang En-Pei Isabel 
Published: July 2022

Abstract
Background:Dietary patterns play important roles in the occurrence and development of numerous human cancers including hepatocellular carcinoma (HCC). In this study, we explored and investigated the potential tumor-promoting genes in mice received high-fat diet (HFD).Methods:We initiated the process by analyzing liver gene expression profile of mice received HFD downloaded from Gene Expression Omnibus (GEO No. GSE108169). Differentially overexpressed genes were assembled and analyzed for the clinical prognosis and biological functions in human cancer databases. The Cancer Genome Atlas Liver Hepatocellular Carcinoma (TCGA-LIHC) were screened by The University of ALabama at Birmingham CANcer data analysis Portal (UALCAN), Human Protein Atlas (HPA), LinkedOmics analysis, TIMER2.0, and Q-omics analysis. Survival analyses were performed to examine the significance for the newly identified biomarkers for HCC.Results: Among the top 10 overexpressing genes in HFD-fed mice liver, a neuron-specific protein, dynamin 1 (DNM1) was identified as a significant prognostic predictor for poor HCC survival examined by UALCAN. Using HPA, we discovered that normal liver tissue does not express DNM1 protein whereas it was found in 30% HCC, and abundant DNM1 protein was detected in HCC cell cytoplasm and membrane. DNM1 gene expression is positively correlated some genes enhanced epithelial-mesenchymal transition (EMT), proliferation, and neural transduction signaling, and its negatively correlated genes enhanced certain metabolism and host-defense ability. Furthermore, positive correlations between DNM1 and CD8 T cells, regulatory T cells (Treg), B cells, macrophages, and natural killer (NK) cells were observed, indicating possible associations between DNM1 and infiltrating immune cells. We then identified a common gene, TAR (HIV-1) RNA Binding Protein 1 (TARBP1) by overlapping the differentially downregulated genes of HCC cells with single-guide DNM1 (sgDNM1), short-hairpin DNM1 (shDNM1), and the TCGA DNM1 correlated genes that also correlated significantly with poor overall survival and disease-free survival of HCC. ConclusionsThis is the first study proposing a role of the HFD-induced hepatic DNM1 over-expression might affect tumor development and immune microenvironment in human HCC. The discovery of this novel marker can add insights into the link of high fat diet and HCC, and provide potential therapeutic target pathways for treating HCC. We suggest DNM1 be a potential prognostic biomarker and therapeutic target for HCV-positive human HCC.
On the dynamics of non-spherical test particle in the spatial collinear restricted four-body problem
Authors: Asique Chand , Alhowaity Sawsan , Alhowaity Awatif , Aggarwal Rajiv , SURAJ Md SANAM , Hamam Haneem 
Published: July 2022

Abstract
In the present manuscript, the dynamics of the non-spherical test particle in the spatial collinear restricted four-body problem is presented. Using the numerical methods, the parametric variation of the position of libration points (LPs) is illustrated when the oblateness/prolateness parameters vary in the pre-assumed intervals. Moreover, it is also unveiled that how these parameters affect the stability of the LPs and the regions of motion. For all the LPs, we have shown their nature by classifying
them not only in two category i.e., as linearly stable and unstable but also as maxima, index-1, and index-2 saddles.The performed numerical investigations strongly suggest that the oblateness/prolateness parameters are indeed very influential factors in this dynamical model.
The roles of land-ocean geometry and ocean heat transport on continental wetness and its response to climate change
Authors: Scheff Jacob , Frierson Dargan M. W. 
Published: July 2022

Abstract
Terrestrial hydroclimate change projections in full-complexity climate models are characterized by a patchwork of regional drying and wetting responses for most variables, even as temperatures warm and evaporative demand increases. Yet, certain geologic proxies suggest that during warm climates of the deep past, the continents were very wet. Recent studies also find that climate models do not reproduce the observed enhancement of tropical precipitation by the presence of land.

Motivated by this gap in understanding, we explore continental hydroclimates and their responses to global warming in an atmospheric model over several different idealized land-ocean configurations, with ocean heat transport turned on and off. We find that the presence and width of Mediterranean-like subtropical seaways play key roles in wetting the continents, and that the cooling of the tropical ocean by heat transport further wets the tropical continent(s) in a thermally direct response. Critically, configurations with drier (wetter) tropical continents tend to further dry (wet) them with global warming, and these responses are strongly concave-down nonlinear. We also briefly test the roles of land parameters, astronomical choices, and topography.
Association of Dyslipidemia, Renal dysfunction, and Uricemia with HPV mediated Cervical Cancer
Authors: Kushwah Atar Singh , Mishra Rajnikant , Srivast Kirti , Mishra Shambhavi , Banerjee Monisha 
Published: July 2022

Abstract
Recently obesity, dyslipidemia and uricemia has been implemented in cancer progression and development. Therefore, in the present study lipid profile, renal function and uric acid levels have been evaluated and their association has been assessed in HPV-mediated cervical cancer (CaCx) patients. Women diagnosed with CaCx were tested for HPV infection using conventional PCR. Anthro-demographic and clinicopathological characteristics were recorded and samples from patients (n = 103) and healthy women (n = 108) were analyzed for dyslipidemia (total cholesterol, TC; triglycerides, TG; high-density lipoprotein, HDL; low-density lipoprotein, LDL levels), serum urea, creatinine and uric acid using commercially kits. All statistical analysis was done using SPSS (ver.21.0) and GraphPad. Out of 103 CaCx patients, 86 were HPV + ve and 17 were HPV-ve. BMI was associated with HPV + ve with a higher risk (1.55 folds) while cholesterol was relatively significant in HPV-ve cases with a 1.01 folds crude OR. TG, HDL and LDL were found significantly associated with an increased adjusted OR in HPV + ve cases. Urea levels were found significantly higher in HPV + ve as compared to HPV-ve (1.63 vs 1.12 folds Crude OR). while the adjusted OR became deceased in HPV + ve CaCx patients (1.10) compared to HPV-ve CaCx patients (1.31). Both creatinine and uric acid showed significantly higher adjusted OR (11.07, 1.53) in HPV + ve cases as compared to HPV-ve (10.37, 1.46). Dyslipidemia, renal dysfunction, and uricemia were found clinically significant in CaCx patients. Therefore, TG, HDL, LDL, serum urea, creatinine, and uric acid can be used as prognostic biomarkers for HPV-mediated cervical cancer.