bluuebunny/crossref_metadata_2025_split huggingface dataset:
SARS-CoV-2 infection induces a pro-inflammatory cytokine response through cGAS-STING and NF-κB
Authors: Neufeldt Christopher J. , Cerikan Berati , Cortese Mirko , Frankish Jamie , Lee Ji-Young , Plociennikowska Agnieszka , Heigwer Florian , Prasad Vibhu , Joecks Sebastian , Burkart Sandy S. , Zander David Y. , Subramanian Baskaran , Gimi Rayomand , Padmanabhan Seetharamaiyer , Iyer Radhakrishnan , Gendarme Mathieu , El Debs Bachir , Halama Niels , Merle Uta , Boutros Michael , Binder Marco , Bartenschlager Ralf 
Published: January 2022

AbstractSARS-CoV-2 is a novel virus that has rapidly spread, causing a global pandemic. In the majority of infected patients, SARS-CoV-2 leads to mild disease; however, in a significant proportion of infections, individuals develop severe symptoms that can lead to long-lasting lung damage or death. These severe cases are often associated with high levels of pro-inflammatory cytokines and low antiviral responses, which can cause systemic complications. Here, we have evaluated transcriptional and cytokine secretion profiles and detected a distinct upregulation of inflammatory cytokines in infected cell cultures and samples taken from infected patients. Building on these observations, we found a specific activation of NF-κB and a block of IRF3 nuclear translocation in SARS-CoV-2 infected cells. This NF-κB response was mediated by cGAS-STING activation and could be attenuated through several STING-targeting drugs. Our results show that SARS-CoV-2 directs a cGAS-STING mediated, NF-κB-driven inflammatory immune response in human epithelial cells that likely contributes to inflammatory responses seen in patients and could be therapeutically targeted to suppress severe disease symptoms.
Phosphoric acid-modified commercial kieselguhr supported palladium nanoparticles as efficient catalysts for low-temperature hydrodeoxygenation of lignin derivatives in water
Authors: Yangcheng Ruixue , Ran Jiansu , Liu Zhaohui , Cui Yuntong , Wang Jianjian 
Published: January 2022

Phosphoric species incorporated onto commercial Celite interacting with Pd NPs greatly enhance the efficiency of low-temperature hydrodeoxygenation of lignin derivatives in water via accelerating the conversion of the generated intermediate.
Emotional Speech Processing in 3- to 12-Month-Old Infants: Influences of Emotion Categories and Acoustic Parameters
Authors: Kao Chieh , Sera Maria D. , Zhang Yang 
Published: January 2022

Purpose:
The aim of this study was to investigate infants' listening preference for emotional prosodies in spoken words and identify their acoustic correlates.

Method:

Forty-six 3- to-12-month-old infants (
M
age
= 7.6 months) completed a central fixation (or look-to-listen) paradigm in which four emotional prosodies (happy, sad, angry, and neutral) were presented. Infants' looking time to the string of words was recorded as a proxy of their listening attention. Five acoustic variables—mean fundamental frequency (F0), word duration, intensity variation, harmonics-to-noise ratio (HNR), and spectral centroid—were also analyzed to account for infants' attentiveness to each emotion.

Results:
Infants generally preferred affective over neutral prosody, with more listening attention to the happy and sad voices. Happy sounds with breathy voice quality (low HNR) and less brightness (low spectral centroid) maintained infants' attention more. Sad speech with shorter word duration (i.e., faster speech rate), less breathiness, and more brightness gained infants' attention more than happy speech did. Infants listened less to angry than to happy and sad prosodies, and none of the acoustic variables were associated with infants' listening interests in angry voices. Neutral words with a lower F0 attracted infants' attention more than those with a higher F0. Neither age nor sex effects were observed.

Conclusions:
This study provides evidence for infants' sensitivity to the prosodic patterns for the basic emotion categories in spoken words and how the acoustic properties of emotional speech may guide their attention. The results point to the need to study the interplay between early socioaffective and language development.
Diagnostic Decisions of Language Complexity Using Informal Language Assessment Measures
Authors: Bawayan Rebecca , Brown Jennifer A. 
Published: January 2022

Purpose:
The current study aimed to understand the clinical decision-making skills of school-based speech-language pathologists (SLPs) using narrative and expository discourse information from three sources: perception of language through listening to language alone, standardized criterion-referenced narrative assessment data, and word- and morpheme-level language sample analysis data.

Method:
Twenty-eight current school-based SLPs participated in the study. During this study, participants rated language quality and made decisions regarding the provision of language services after being provided information from informal assessment measures.

Results:
SLPs' ratings of language quality and complexity varied across the story retell, wordless picture book generation, and expository samples. There was a lack of consistency in ratings within each context across areas of clarity, sample complexity, language complexity, and vocabulary across all SLPs. Self-reported factors that influenced SLPs' ratings included components of structure, syntax, and semantics. SLPs did not indicate a need for services after listening alone. When provided with criterion-referenced narrative assessment scores and word- and morpheme-level language sample data, more SLPs made a recommendation for services.

Conclusions:
The study demonstrates the need for objective language measure data during diagnostic decision making. Additionally, SLPs may not realize the information obtained from real-time perception, and analysis of language samples may be an unreliable and inconsistent picture of a child's language abilities. The results of this study highlight the need to continue to rely on multiple sources of assessment data. SLPs should continue to incorporate systematic methods to minimize variability of perceptions in the process of making diagnostic decisions.

Supplemental Material:

https://doi.org/10.23641/asha.17707451
The Case for Addressing Emotional Resilience in Graduate Student Training
Authors: Malandraki Jaime Bauer 
Published: January 2022

Purpose:The purpose of this study was to review the evidence for addressing emotional resilience in the training of graduate students in communication sciences and disorders (CSD). As helping professionals, speech-language pathologists and audiologists face unique emotional challenges that can lead to burnout, compassion fatigue, and eventually possible career changes. At the same time, we also know that graduate students across the country, in all disciplines, are in the throes of a mental health crisis. Graduate students in CSD are, therefore, in need of targeted instruction on how to foster emotional resilience both to manage the stressors of graduate school and to ensure professional wellness and career longevity.Conclusions:While there is currently limited research evidence on how to effectively target emotional resilience for graduate students in CSD, existing research and guidance from studies in CSD and other helping professions can provide a framework to follow. The recent mental health challenges facing our nation, and graduate students more specifically, should be seen as both a call to action and an opportunity to elevate the depth of training provided beyond core knowledge and skills to include education on wellness, self-care, and emotional resilience to develop career-long habits.
The Love and Science of Reading: A Promising Instructional Approach for Adolescent Multilingual Learners
Authors: Farran Lama K. , Griffin Robert A. 
Published: January 2022

Purpose:Adolescent multilingual learners are at high risk for reading difficulties as evidenced by persistent achievement gaps. This article calls for a paradigm shift and aims to elucidate what constitutes promising second-language literacy instruction for multilingual adolescents, comprising effective literacy practices grounded in research, combined with an emphasis on individual learners and their sociocultural development. Cast in ecological systems and functionalist perspectives, this article provides a model for language and literacy instruction that is grounded in basic tenets of reading science within a sociocultural context. We outline strategies that focus on language as a basis for reading development followed by examples of authentic learning experiences designed to motivate students and nurture their love of reading.Conclusions:A solution to existing achievement gaps may be a promising approach that emphasizes both the science and love of reading, which entails targeted instruction rooted in the research evidence integrated into engaging and meaningful learning experiences, central to which is the acknowledgement of multilingual learners as individuals. The authors call for an intentional focus on accelerating the development of language through frequent use of and a genuine love for both the science of reading and the science of teaching reading.
A data‐driven approach to state assessment of the converter valve based on oversampling and Shapley additive explanations
Authors: Mei Fei , Li Xuan , Zheng Jianyong , Sha Haoyuan , Li Danqi 
Published: January 2022

AbstractThe utilization of data‐driven artificial intelligence technology for ultra‐high voltage converter valve state assessment can improve efficiency and accuracy, but there are still problems such as imbalance of raw data and poor model interpretability. This paper aims to propose a new type of ultra‐high voltage converter valve state assessment method to solve these problems. An oversampling method that considers characteristic boundary information is proposed, which can retain and enhance the boundary information of minority samples. The balanced data are imported into categorical boosting to realize offline training and online evaluation of converter valve state assessment. An interpretability analysis framework of the converter valve state assessment model based on the Shapley additive explanations is proposed, which can explain the operation logic of the model and find the key factors that affect the assessment results. The calculation example shows that the evaluation accuracy of this method can reach up to 98.5%, and the running speed is faster than the conventional method. The results can provide guidance for the maintenance and repair of UHV converter valves.
Synthesis and intensification of a biorefinery to produce renewable aviation fuel, biofuels, bioenergy and chemical products from Jatropha Curcas fruit
Authors: Romero‐Izquierdo Araceli Guadalupe , Gutiérrez‐Antonio Claudia , Gómez‐Castro Fernando Israel , Hernández Salvador 
Published: January 2022

AbstractThe production of renewable aviation fuel has been explored in recent years considering different types of biomasses and several conversion pathways. The technical feasibility of the production of renewable aviation fuel has already been proved; however, the main challenge is to achieve economic and environmental sustainability regarding to its fossil counterparts. In this context, the integrated biorefineries are a potential strategy to address these challenges. Therefore, in this work it is presented the conversion of Jatropha curcas fruit through a biorefinery to produce renewable aviation fuel, biofuels, bioenergy and chemical products. The synthesis, modelling and simulation of each processing stage in the biorefinery is presented, along with its economic and environmental assessment. Moreover, the intensification of the purification zone is addressed. According to the results, biojet fuel, biodiesel, glycerol, fertilizer, green diesel, naphtha and electricity are produced through the biorefinery. In addition, less than 1% of energy savings were obtained due to intensified sequence to separate biojet fuel. Also, 90% of the total electricity consumption is covered by its generation in situ, improving the environmental sustainability of the production of renewable aviation fuel.
Mobilisation auf Intensivstationen: Intensivpflegezimmer und Medizintechnik können helfen
Authors: Grunow Julius J. , Nydahl Peter , Schaller Stefan J. 
Published: January 2022

Zusammenfassung(Früh-)Mobilisation ist ein wichtiges Element auf der Intensivstation – es dient der Prävention und Therapie der durch eine kritische Erkrankung verursachten Einschränkungen der körperlichen Funktion. Aufgrund diverser Barrieren werden die aktuellen Leitlinien-Ziele aber nicht immer erreicht. In diesem Beitrag geht es um die Integration des Intensivpflegezimmers und moderner Medizintechnik in die Frühmobilisation zur Überwindung dieser Barrieren.
Letaler Hitzeschock mit disseminierter intravasaler Koagulopathie
Authors: Herpertz Gerrit U. , Nykamp Lukas , Radke Oliver C. 
Published: January 2022

ZusammenfassungDas Thema hitzebedingter Erkrankungen ist in den letzten Jahren mit überaus heißen Sommern und häufigen Hitzewellen immer relevanter geworden. Epidemiologisch lassen sich solche Erkrankungen nur schwer fassen, da sie saisonal vorkommen und überwiegend besonders exponierte Patienten betreffen. Fatale Verläufe wie der im Beitrag beschriebene sind äußerst selten 1.
Bettina lebt – Kälberdurchfall in der
homöopathischen Praxis
Authors: Gerke Stephan 
Published: January 2022

ZusammenfassungAnhand eines Falles von Kälberdurchfall wird die Arzneimittelfindung
mithilfe eines Repertorisationsprogramms und des Symptomenlexikons dargestellt.
Hierbei wird Secale cornutum als am besten indiziertes Arzneimittel gefunden.
Die Anwendung von Secale cornutum bei Kälberdurchfall wird
diskutiert.
Endoscopic retrograde appendicitis therapy versus laparoscopic appendectomy for uncomplicated acute appendicitis
Authors: Yang Baohong , Kong Lingjian , Ullah Saif , Zhao Lixia , Liu Dan , Li Deliang , Shi Xuezhong , Jia Xiaocan , Dalal Paras , Liu Bingrong 
Published: January 2022

Background Endoscopic retrograde appendicitis therapy (ERAT) is a new and minimally invasive technique for the treatment of acute appendicitis. This study aimed to assess the efficacy and clinical outcomes of ERAT versus laparoscopic appendectomy for patients with uncomplicated acute appendicitis.
Methods We adopted propensity score matching (1:1) to compare ERAT and laparoscopic appendectomy in patients with uncomplicated acute appendicitis between April 2017 and March 2020. We reviewed 2880 patients with suspected acute appendicitis, of whom 422 patients with uncomplicated acute appendicitis met the matching criteria (ERAT 79; laparoscopic appendectomy 343), yielding 78 pairs of patients.
Results The rate of curative treatment within 1 year after ERAT was 92.1 % (95 % confidence interval [CI] 83.8 % to 96.3 %). The percentage of patients recording visual analog scale values of  ≤ 3 for pain at 6 hours after treatment was 94.7 % (95 %CI 87.2 % to 97.9 %) in the ERAT group, which was significantly higher than that in the laparoscopic appendectomy group (83.3 %; 95 %CI 73.5 % to 90.0 %). Median procedure time and median hospital length of stay were significantly lower in the ERAT group compared with the laparoscopic appendectomy group. At 1 year, the median recurrence time was 50 days (interquartile range 25–127) in the ERAT group. The overall adverse event rate was 24.4 % (95 %CI 14.8 % to 33.9 %) in the laparoscopic appendectomy group and 18.4 % (95 %CI 9.7 % to 27.1 %) in the ERAT group, with no significant difference between the two groups.
Conclusion ERAT was a technically feasible method of treating uncomplicated acute appendicitis compared with laparoscopic appendectomy.
Effectiveness of Clinical Decision Support Systems on the Appropriate Use of Imaging for Central Nervous System Injuries: A Systematic Review
Authors: Zare Sahar , Mobarak Zohre , Meidani Zahra , Nabovati Ehsan , Nazemi Zahra 
Published: January 2022

Abstract
Background One of the best practices for timely and efficient diagnoses of central nervous system (CNS) trauma and complex diseases is imaging. However, rates of imaging for CNS are high and impose a lot of costs to health care facilities in addition to exposing patients with negative impact of ionizing radiation.
Objectives This study aimed to systematically review the effects and features of clinical decision support systems (CDSSs) for the appropriate use of imaging for CNS injuries.
Method We searched MEDLINE, SCOPUS, Web of Science, and Cochrane without time period restriction. We included experimental and quasiexperimental studies that assessed the effectiveness of CDSSs designed for the appropriate use of imaging for CNS injuries in any clinical setting, including primary, emergency, and specialist care. The outcomes were categorized based on imaging-related, physician-related, and patient-related groups.
Result A total of 3,223 records were identified through the online literature search. Of the 55 potential papers for the full-text review, 11 eligible studies were included. Reduction of CNS imaging proportion varied from 2.6 to 40% among the included studies. Physician-related outcomes, including guideline adherence, diagnostic yield, and knowledge, were reported in five studies, and all demonstrated positive impact of CDSSs. Four studies had addressed patient-related outcomes, including missed or delayed diagnosis, as well as length of stay. These studies reported a very low rate of missed diagnosis due to the cancellation of computed tomography (CT) examine according to the CDSS recommendations.
Conclusion This systematic review reports that CDSSs decrease the utilization of CNS CT scan, while increasing physicians' adherence to the rules. However, the possible harm of CDSSs to patients was not well addressed by the included studies and needs additional investigation. The actual effect of CDSSs on appropriate imaging would be realized when the saved cost of examinations is compared with the cost of missed diagnosis.
Gastrointestinal Bleeding in Congenital Bleeding Disorders
Authors: Samii Amir , Norouzi Mahshaad , Ahmadi Abbas , Dorgalaleh Akbar 
Published: January 2022

AbstractGastrointestinal bleeding (GIB) is serious, intractable, and potentially life-threatening condition. There is considerable heterogeneity in GIB phenotypes among congenital bleeding disorders (CBDs), making GIB difficult to manage. Although GIB is rarely encountered in CBDs, its severity in some patients makes the need for a comprehensive and precise assessment of underlying factors and management approaches imperative. Initial evaluation of GIB begins with assessment of hematological status; GIB should be ruled out in patients with chronic anemia, and in presentations that include hematemesis, hematochezia, or melena. High-risk patients with recurrent GIB require urgent interventions such as replacement therapy for treatment of coagulation factor deficiency (CFD). However, the best management strategy for CFD-related bleeding remains controversial. While several investigations have identified CBDs as potential risk factors for GIB, research has focused on assessing the risks for individual factor deficiencies and other CBDs. This review highlights recent findings on the prevalence, management strategies, and alternative therapies of GIB related to CFDs, and platelet disorders.
Interaction between Antiphospholipid Antibodies and Protein C Anticoagulant Pathway: A Narrative Review
Authors: Pengo Vittorio 
Published: January 2022

AbstractThrombotic antiphospholipid syndrome (APS) is a condition in which thrombosis in venous, arterial, and/or small vessels is ascribed to the presence of antiphospholipid antibodies (aPL). Among the various proposed pathogenic theories to explain thrombotic APS, those involving the interaction between aPL and the protein C system have gained much consensus. Indeed, robust data show an acquired activated protein C resistance (APC-R) in these patients. The role of aPL in this impairment is clear, but the mechanism of action is uncertain, as the type of aPL and to what extent aPL are involved remains a gray area. Lupus anticoagulant (LA) is often associated with APC-R, but antibodies generating LA comprise those directed to β2-glycoprotein I and antiphosphatidylserine/prothrombin. Moreover, the induction of APC-R by aPL requires the presence of phospholipids and is suppressed by the presence of an excess of phospholipids. How phospholipids exposed on the cell membranes work in the system in vivo is unknown. Interestingly, acquired APC-R due to aPL might explain the clinical phenotypes of thrombotic APS. Indeed, the literature reports cases of both venous and arterial thromboembolism as well as skin necrosis, the latter observed in the severe form of protein C deficiency and in catastrophic APS.
Transcranial Color Coded Duplex Sonography Findings in Stroke Patients Undergoing Rehabilitation: An Observational Study
Authors: Venkatakrishnan Srikant , Khanna Meeka , Gupta Anupam 
Published: January 2022

Abstract

Background Transcranial color-coded duplex sonography (TCCD) provides information on intracranial blood flow status in stroke patients and can predict rehabilitation outcomes.

Objective This study aimed to assess middle cerebral artery (MCA) parameters using TCCD in MCA territory stroke patients admitted for rehabilitation and correlate with clinical outcome measures.

Materials and Methods Patients aged 18 to 65 years with a first MCA territory stroke, within 6 months of onset were recruited. The clinical outcome scales and TCCD parameters were assessed at both admission and discharge. The scales used were the Scandinavian stroke scale (SSS), Barthel Index (BI), modified Rankin Scale (mRS), Fugl–Meyer upper extremity scale (FMA-UE), modified motor assessment scale (mMAS) scores. TCCD parameters measured were MCA peak systolic, end diastolic, mean flow velocities (MFV), and index of symmetry (SI) and were correlated with clinical scores.

Results Fourteen patients were recruited with median age of 56.5 years, median duration of stroke was 42.5 days. Mean flow velocities of affected and unaffected MCA were 46.2 and 50.7 cm/s, respectively. Flow velocities and SI did not change between the two assessments. There was significant improvement in clinical outcome scores at discharge. Significant correlation was observed for patient group with SI > 0.9 at admission with FMA-UE, SSS, and BI scores at discharge (p < 0.05).

Conclusion Flow velocity parameters did not change during in-patient rehabilitation. Patients with symmetric flow at admission had improved clinical outcomes measure scores at discharge. Thus SI can predict rehabilitation outcomes in stroke survivors.