bluuebunny/crossref_metadata_2025_split huggingface dataset:
No association between prenatal lead exposure and neurodevelopment during early childhood in the Japan Environment and Children’s Study
Authors: Inoue Hirosuke , Sanefuji Masafumi , Sonoda Yuri , Ogawa Masanobu , Hamada Norio , Shimono Masayuki , Suga Reiko , Nakayama Shoji F. , Taniguchi Yu , Kusuhara Koichi , Ohga Shouichi , Kamijima Michihiro ,   The Japan Environment and Children’s Study Group, Kamijima Michihiro , Yamazaki Shin , Ohya Yukihiro , Kishi Reiko , Yaegashi Nobuo , Hashimoto Koichi , Mori Chisato , Ito Shuichi , Yamagata Zentaro , Inadera Hidekuni , Nakayama Takeo , Iso Hiroyasu , Shima Masayuki , Nakamura Hiroshige , Suganuma Narufumi , Kusuhara Koichi , Katoh Takahiko 
Published: September 2022

AbstractCompared with the relatively well-investigated effects of childhood exposure to lead on neurocognitive deficits, those of prenatal exposure remain relatively inconclusive. We aimed to investigate the association between prenatal blood lead levels and neurodevelopmental delay during the first three years of life. From a prospective cohort of the Japan Environment and Children’s Study, we analyzed a total of 80,759 children. The exposure factors were prenatal lead concentrations measured from maternal whole blood in the second/third trimesters and umbilical cord blood at birth. Neurodevelopment was assessed at 6, 12, 18, 24, 30, and 36 months old using a screening tool, the Ages and Stages Questionnaires, third edition (ASQ). The outcome measures were any suspected neurodevelopmental delay (sNDD) identified via the ASQ during the first (sNDD-1Y), second (sNDD-2Y), and third (sNDD-3Y) years of life. sNDD-1Y, 2Y, and 3Y were identified in 18.0%, 16.2%, and 17.2% of children, respectively. The geometric means of blood lead concentration in this study were much lower (0.62 μg/dL in maternal blood and 0.50 μg/dL in cord blood) than previously investigated levels. Multivariable regression models revealed that there were no associations between maternal blood lead and sNDD-1Y and 2Y and between cord blood lead and sNDD-1Y, 2Y, and 3Y. Although a higher maternal blood lead was associated with a reduced risk of sNDD-3Y (adjusted relative risk: 0.84, 95% confidence interval 0.75–0.94, per 1 increase in common logarithm of lead concentration), there were no dose–response relationships in the analysis using quintiles of lead concentrations. Using a large-scale data set, the present study demonstrated no convincing evidence for an inverse association between levels of prenatal blood lead and neurodevelopment in early childhood. Longitudinal measurements of prenatal and postnatal lead levels are needed to understand the relationship between lead exposure and neurocognitive development.
Photobiomodulation regulates adult neurogenesis in the hippocampus in a status epilepticus animal model
Authors: Hong Namgue , Kang Gi Won , Park Ji On , Chung Phil-Sang , Lee Min Young , Ahn Jin-Chul 
Published: September 2022

AbstractStatus epilepticus (SE) refers to a single seizure that lasts longer than typical seizures or a series of consecutive seizures. The hippocampus, which is vulnerable to the effects of SE, has a critical role in memory storage and retrieval. The trisynaptic loop in the hippocampus connects the substructures thereof, namely the dentate gyrus (DG), CA3, and CA1. In an animal model of SE, abnormal neurogenesis in the DG and aberrant neural network formation result in sequential neural degeneration in CA3 and CA1. Photobiomodulation (PBM) therapy, previously known as low-level laser (light) therapy (LLLT), is a novel therapy for the treatment of various neurological disorders including SE. However, the effects of this novel therapeutic approach on the recovery process are poorly understood. In the present study, we found that PBM transformed SE-induced abnormal neurogenesis to normal neurogenesis. We demonstrated that PBM plays a key role in normal hippocampal neurogenesis by enhancing the migration of maturing granular cells (early neuronal cells) to the GCL, and that normal neurogenesis induced by PBM prevents SE-induced hippocampal neuronal loss in CA1. Thus, PBM is a novel approach to prevent seizure-induced neuronal degeneration, for which light devices may be developed in the future.
Musical training refines audiovisual integration but does not influence temporal recalibration
Authors: O’Donohue Matthew , Lacherez Philippe , Yamamoto Naohide 
Published: September 2022

AbstractWhen the brain is exposed to a temporal asynchrony between the senses, it will shift its perception of simultaneity towards the previously experienced asynchrony (temporal recalibration). It is unknown whether recalibration depends on how accurately an individual integrates multisensory cues or on experiences they have had over their lifespan. Hence, we assessed whether musical training modulated audiovisual temporal recalibration. Musicians (n = 20) and non-musicians (n = 18) made simultaneity judgements to flash-tone stimuli before and after adaptation to asynchronous (± 200 ms) flash-tone stimuli. We analysed these judgements via an observer model that described the left and right boundaries of the temporal integration window (decisional criteria) and the amount of sensory noise that affected these judgements. Musicians’ boundaries were narrower (closer to true simultaneity) than non-musicians’, indicating stricter criteria for temporal integration, and they also exhibited enhanced sensory precision. However, while both musicians and non-musicians experienced cumulative and rapid recalibration, these recalibration effects did not differ between the groups. Unexpectedly, cumulative recalibration was caused by auditory-leading but not visual-leading adaptation. Overall, these findings suggest that the precision with which observers perceptually integrate audiovisual temporal cues does not predict their susceptibility to recalibration.
Survival comparison between endoscopic and surgical resection for non-ampullary duodenal neuroendocrine tumor (1–2 cm)
Authors: Xie Jiebin , Zhang Yuan , He Ming , Liu Xu , Xie Pin , Pang Yueshan 
Published: September 2022

AbstractThe treatment plan for non-ampullary duodenal neuroendocrine tumors (d-NETs) with diameters 1–2 cm remains controversial. We therefore aimed to compare the prognostic effects of endoscopic treatment and surgical resection on non-ampullary d-NETs with 1–2 cm diameters. A total of 373 eligible patients were identified from the Surveillance, Epidemiology, and End Results (SEER) database. Propensity score matching (PSM) was performed to match patients 1:1 according to clinicopathological characteristics. Disease-specific survival (DSS) and overall survival (OS) were calculated. Before PSM, there was no significant difference in DSS or OS (all P > 0.05), but the T stage, N stage, and TNM stage were significantly different between the two surgical methods (all P < 0.05). After 1:1 PSM, the differences in clinicopathological characteristics were significantly reduced (all P > 0.05). Survival analysis showed that tumor grade was correlated with DSS and that age was correlated with OS (all P < 0.05); however, the surgical method and other clinicopathological characteristics were not correlated with prognosis (all P > 0.05). Subgroup survival analysis of patients with T2N0M0 disease and tumors invading the lamina propria or submucosa showed that the 5-year DSS and OS rates were not significantly different according to the surgical approach (all P > 0.05). The surgical approach has no significant effect on the prognosis of patients with non-ampullary d-NETs with 1–2 cm diameters, especially those with T2N0M0 disease. This suggests that endoscopic treatment may be a preferred option for these patients.
Cocaine’s cerebrovascular vasoconstriction is associated with astrocytic Ca2+ increase in mice
Authors: Liu Yanzuo , Hua Yueming , Park Kicheon , Volkow Nora D. , Pan Yingtian , Du Congwu 
Published: September 2022

AbstractHuman and animal studies have reported widespread reductions in cerebral blood flow associated with chronic cocaine exposures. However, the molecular and cellular mechanisms underlying cerebral blood flow reductions are not well understood. Here, by combining a multimodal imaging platform with a genetically encoded calcium indicator, we simultaneously measured the effects of acute cocaine on neuronal and astrocytic activity, tissue oxygenation, hemodynamics and vascular diameter changes in the mouse cerebral cortex. Our results showed that cocaine constricted blood vessels (measured by vessel diameter Φ changes), decreasing cerebral total blood volume (HbT) and temporally reducing tissue oxygenation. Cellular imaging showed that the mean astrocytic Ca2+ dependent fluorescence $$(\Delta {F/F}_{{{{\rm{Ca}}}^{2+}}{\mbox{-}{{{\rm{G(A)}}}}}})$$

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increase in response to cocaine was weaker but longer lasting than the mean neuronal Ca2+ dependent fluorescence $$(\Delta {F/F}_{{{{\rm{Ca}}}^{2+}}{\mbox{-}{{{\rm{G(N)}}}}}})$$

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changes. Interestingly, while cocaine-induced $$\Delta {F/F}_{{{{\rm{Ca}}}^{2+}}{\mbox{-}{{{\rm{G(N)}}}}}}$$
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increase was temporally correlated with tissue oxygenation change, the $$\Delta {F/F}_{{{{\rm{Ca}}}^{2+}}{\mbox{-}{{{\rm{G(A)}}}}}}$$
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elevation after cocaine was in temporal correspondence with the long-lasting decrease in arterial blood volumes. To determine whether the temporal association between astrocytic activation and cocaine induced vasoconstriction reflected a causal association we inhibited astrocytic Ca2+ using GFAP-DREADD(Gi). Inhibition of astrocytes attenuated the vasoconstriction resulting from cocaine, providing evidence that astrocytes play a critical role in cocaine’s vasoconstrictive effects in the brain. These results indicate that neurons and astrocytes play different roles in mediating neurovascular coupling in response to cocaine. Our findings implicate neuronal activation as the main driver of the short-lasting reduction in tissue oxygenation and astrocyte long-lasting activation as the driver of the persistent vasoconstriction with cocaine. Understanding the cellular and vascular interaction induced by cocaine will be helpful for future putative treatments to reduce cerebrovascular pathology from cocaine use.
In situ grown oxygen-vacancy-rich copper oxide nanosheets on a copper foam electrode afford the selective oxidation of alcohols to value-added chemicals
Authors: Khan Mustafa , Hameed Asima , Samad Abdus , Mushiana Talifhani , Abdullah Muhammad Imran , Akhtar Asma , Ashraf Raja Shahid , Zhang Ning , Pollet Bruno G. , Schwingenschlögl Udo , Ma Mingming 
Published: September 2022

AbstractSelective oxidation of low-molecular-weight aliphatic alcohols like methanol and ethanol into carboxylates in acid/base hybrid electrolytic cells offers reduced process operating costs for the generation of fuels and value-added chemicals, which is environmentally and economically more desirable than their full oxidation to CO2. Herein, we report the in-situ fabrication of oxygen-vacancies-rich CuO nanosheets on a copper foam (CF) via a simple ultrasonication-assisted acid-etching method. The CuO/CF monolith electrode enables efficient and selective electrooxidation of ethanol and methanol into value-added acetate and formate with ~100% selectivity. First principles calculations reveal that oxygen vacancies in CuO nanosheets efficiently regulate the surface chemistry and electronic structure, provide abundant active sites, and enhance charge transfer that facilitates the adsorption of reactant molecules on the catalyst surface. The as-prepared CuO/CF monolith electrode shows excellent stability for alcohol oxidation at current densities >200 mA·cm2 for 24 h. Moreover, the abundant oxygen vacancies significantly enhance the intrinsic indicators of the catalyst in terms of specific activity and outstanding turnover frequencies of 5.8k s−1 and 6k s−1 for acetate and formate normalized by their respective faradaic efficiencies at an applied potential of 1.82 V vs. RHE.
Sporopollenin-inspired design and synthesis of robust polymeric materials
Authors: Glinkerman Christopher M. , Lin Shaoting , Ni Jiahua , Li Fu-Shuang , Zhao Xuanhe , Weng Jing-Ke 
Published: September 2022

AbstractSporopollenin is a mechanically robust and chemically inert biopolymer that constitutes the outer protective exine layer of plant spores and pollen grains. Recent investigation of the molecular structure of pine sporopollenin revealed unique monomeric units and inter-unit linkages distinct from other previously known biopolymers, which could be harnessed for new material design. Herein, we report the bioinspired synthesis of a series of sporopollenin analogues. This exercise confirms large portions of our previously proposed pine sporopollenin structural model, while the measured chemical, thermal, and mechanical properties of the synthetic sporopollenins constitute favorable attributes of a new kind of robust material. This study explores a new design framework of robust materials inspired by natural sporopollenins, and provides insights and reagents for future elucidation and engineering of sporopollenin biosynthesis in plants.
Subsurface Archaea associated with rapid geobiological change in a model Yellowstone hot spring
Authors: Colman Daniel R. , Amenabar Maximiliano J. , Fernandes-Martins Maria C. , Boyd Eric S. 
Published: September 2022

AbstractDespite over a century of study, it is unknown if continental hydrothermal fields support high-temperature subsurface biospheres. Cinder Pool is among the deepest hot springs in Yellowstone and is widely studied due to unique sulfur geochemistry that is attributed to hydrolysis of molten elemental sulfur at ∼18 m depth that promotes several chemical reactions that maintain low sulfide, low oxygen, and a moderate pH of ∼4.0. Following ∼100 years of stability, Cinder Pool underwent extreme visual and chemical change (acidification) in 2018. Here, we show that depth-resolved geochemical and metagenomic-based microbial community analyses pre- (2016) and post-acidification (2020) indicate the changes are likely attributable to feedbacks between geological/geochemical processes, sulfur oxidation by subsurface Sulfolobales Archaea, and the disappearance of molten sulfur at depth. These findings underscore the dynamic and rapid feedback between the geosphere and biosphere in continental hydrothermal fields and suggest subsurface biospheres to be more prevalent in these systems than previously recognized.
Anthropogenic aerosol and cryosphere changes drive Earth’s strong but transient clear-sky hemispheric albedo asymmetry
Authors: Diamond Michael S. , Gristey Jake J. , Kay Jennifer E. , Feingold Graham 
Published: September 2022

AbstractA striking feature of the Earth system is that the Northern and Southern Hemispheres reflect identical amounts of sunlight. This hemispheric albedo symmetry comprises two asymmetries: The Northern Hemisphere is more reflective in clear skies, whereas the Southern Hemisphere is cloudier. Here we show that the hemispheric reflection contrast from differences in continental coverage is offset by greater reflection from the Antarctic than the Arctic, allowing the net clear-sky asymmetry to be dominated by aerosol. Climate model simulations suggest that historical anthropogenic aerosol emissions drove a large increase in the clear-sky asymmetry that would reverse in future low-emission scenarios. High-emission scenarios also show decreasing asymmetry, instead driven by declines in Northern Hemisphere ice and snow cover. Strong clear-sky hemispheric albedo asymmetry is therefore a transient feature of Earth’s climate. If all-sky symmetry is maintained, compensating cloud changes would have uncertain but important implications for Earth’s energy balance and hydrological cycle.
Next-generation sequencing of Tunisian Leigh syndrome patients reveals novel variations: impact for diagnosis and treatment
Authors: Hechmi Meriem , Charif Majida , Kraoua Ichraf , Fassatoui Meriem , Dallali Hamza , Desquiret-Dumas Valerie , Bris Céline , Goudenège David , Drissi Cyrine , Galaï Saïd , Ouerhani Slah , Procaccio Vincent , Amati-Bonneau Patrizia , Abdelhak Sonia , Ben Youssef-Turki Ilhem , Lenaers Guy , Kefi Rym 
Published: September 2022

Abstract
Mitochondrial cytopathies, among which the Leigh syndrome (LS), are caused by variants either in the mitochondrial or the nuclear genome, affecting the oxidative phosphorylation process. The aim of the present study consisted in defining the molecular diagnosis of a group of Tunisian patients with LS.
Six children, belonging to five Tunisian families, with clinical and imaging presentations suggestive of LS were recruited. Whole mitochondrial DNA and targeted next-generation sequencing of a panel of 281 nuclear genes involved in mitochondrial physiology were performed. Bioinformatic analyses were achieved in order to identify deleterious variations.
A single m.10197G&gt;A (p.Ala47Thr) variant was found in the mitochondrial MT-ND3 gene in one patient, while the others were related to autosomal homozygous variants: two c.1412delA (p.Gln471ArgfsTer42) and c.1264A&gt;G (p.Thr422Ala) in SLC19A3, one c.454C&gt;G (p.Pro152Ala) in SLC25A19 and one c.122G&gt;A (p.Gly41Asp) in ETHE1.
Our findings demonstrate the usefulness of genomic investigations to improve LS diagnosis in consanguineous populations and further allow for treating the patients harboring variants in SLC19A3 and SLC25A19 that contribute to thiamine transport, by thiamine and biotin supplementation. Considering the Tunisian genetic background, the newly identified variants could be screened in patients with similar clinical presentation in related populations.
Comprehensive analysis of DTYMK in pan-cancer and verification in lung adenocarcinoma
Authors: Zhang Yue , Wang Hao , Liu Ying , Yang Jing , Zuo Xiaoxiao , Dong Meilian , Zhang Zhigang , Shi Yonggang , Deng Xubin , Lv Yaoyong 
Published: September 2022

Abstract
Previous documents have reported that the deoxythymidylate kinase (DTYMK) genes were involved in the progression of cancers. However, its significance in the analysis of pan-cancer and specific molecular mechanism were still poorly understood. In the present study, we conducted a comprehensive study of the DTYMK gene associated with its clinical relevance across a broad-spectrum of human tumors. In addition, association among DTYMK gene and tumor immunogenic features was also explored. Considering the results of pan-cancer analysis, the specific tumor lung adenocarcinoma (LUAD) was chosen to further study the DTYMK-induced signaling pathways and intercellular communications in tumor progression. Our findings demonstrated that DTYMK may be a new biomarker for the prognosis and immunotherapy in various cancers. Importantly, DTYMK was expected to be a guiding marker gene for clinical prognosis and tumor personalized therapy in LUAD.
Bitcoin transactions as a graph
Authors: Di Zhensheng , Wang Guan , Jia Lili , Chen Zhuoyi 
Published: September 2022

AbstractNowadays, blockchain is an upcoming area for researchers from different research fields. Bitcoin, as the first successful cryptocurrency, has accumulated numerous data after its existence. Here, the Bitcoin transaction graph from a graph theory perspective is investigated with more available data given now. This paper mainly focuses on the transaction graph and provides researchers with both practical and theoretical sides of the data. Several existent measurements and some newer ones are first computed and analysed. These measurements help to interpret the transaction graph more extensively. A new modified Buckley–Osthus random graph model is proposed, and a simulation of the Chung–Lu model is attempted to represent the Bitcoin transaction network. Some suggestions are given to improve the modified Buckley–Osthus model and point out the pros and cons of these random graph models. Moreover, the experiments show that scale‐free networks are fundamentally not a good model for Bitcoin transaction networks considering all the data, but the mechanics of preferential attachment is crucial. How to proceed with Bitcoin transaction graph theory from both theoretical and experimental perspectives for future studies is also discussed and analysed.
Precise motion compensation method in terahertz ISAR imaging based on sharpness maximization
Authors: Wang Hetong , Yang Qi , Wang Hongqiang , Deng Bin 
Published: September 2022

AbstractAccording to the characteristics of the manoeuvring targets and the superiorities of Terahertz Inverse Synthetic Aperture Radar (THz‐ISAR), a precise motion compensation method based on image sharpness maximization for manoeuvring targets in the terahertz radar was proposed in this letter. Computational efficiency and compensation accuracy are improved by modified Newton's method. Then a 330‐GHz imaging radar and an experiment on a corner reflector were introduced. The validity of the method was verified, by the experimental results, to be promising in THz‐ISAR imaging of manoeuvring targets.
Joint radar communication system design based on filter bank multicarrier modulation scheme
Authors: Liu Gaogao , Yang Wenbo , Bao Yuqian , Wang Youming , Li Peng , He Zi'ang 
Published: September 2022

AbstractSince orthogonal frequency division multiplexing (OFDM) signals are sensitive to Doppler shift, OFDM signals with cyclic prefix (CP) not only reduce the communication rate but also result in symmetric pseudo peaks in the ambiguity function of the radar, which eventually lead to the degradation of the performance of the joint radar communication system (JRCS). In this study, a novel JRCS is proposed based on the filter bank multicarrier (FBMC) waveform for the inverse synthetic aperture radar (ISAR) imaging and communication system. On the one hand, FBMC waveforms are capable of low orthogonality between subcarriers, which can counter Doppler and multipath effects. On the other hand, FBMC waveforms do not require CP, so the false targets can be avoided and spectral efficiency can be improved. The influence of multipath effect and Doppler shift on FBMC waveform in an integrated system is analysed in detail, and a Doppler compensation algorithm suitable for FBMC‐integrated waveform is proposed. The phase error caused by target motion can be iteratively compensated to obtain a well‐focussed ISAR image. Finally, considering the ISAR image entropy after motion compensation as the evaluation metric, extensive simulation experiments verify the noise robustness and effectiveness of the proposed algorithm. Compared with the conventional OFDM and CP‐OFDM schemes, the simulation verifies that the proposed waveform design and processing method has better performance in the ISAR imaging and communication integrated system.