bluuebunny/crossref_metadata_2025_split huggingface dataset:
Volatility criteria and physicochemical properties of the promising dimethyl carbonate-gasoline blends
Authors: Amine Manal , Mohammed Hoda A. , Barakat Y 
Published: October 2022

AbstractIncreased need for energy resources, as well as the urgent need to improve the air quality, have prompted further research to meet these challenges. Great efforts have been directed to reducing the impact of exhaust emissions. In literature, the effect of blending dimethyl carbonate (DMC) into fuel on engine performance and exhaust emissions has been investigated, and the obtained results were promising in decreasing exhaust emissions. In the present work, the effect of blending DMC into gasoline on the physicochemical properties was studied. Six fuel blends were prepared by blending base gasoline (G) with (0%, 2%, 4%, 6%, 8%, and 10%) of DMC. The volatility characteristics of the fuel blends were studied, such as the distillation curve, vapor pressure, and driveability index. The octane rating and the physicochemical properties of the fuel blends were also studied. The results of the study showed interesting findings that encourage refineries to be interested in this promising fuel additive. The results showed that the addition of DMC to gasoline has a very slight effect on the volatility of gasoline, unlike other oxygenated additives like short chain alcohols which cause a significant increase in the fuel volatility. The addition of DMC to gasoline causes an insignificant increase in the vapor pressure as the addition of 10% of DMC increases the vapor pressure by 2 kPa while it does not affect the values of T10, T50, and T90, which are the most important parameters of the distillation curve. The results also showed that its addition causes a remarkable increase in the octane rating. The RON has increased for the G-10DMC blend by about 5 points making the DMC a promising octane booster.
Effects of incubation temperature on development, morphology, and thermal physiology of the emerging Neotropical lizard model organism Tropidurus torquatus
Authors: De-Lima Anderson Kennedy Soares , de Oliveira Carlos Henke , Pic-Taylor Aline , Klaczko Julia 
Published: October 2022

AbstractIncubation temperature is among the main phenotypic trait variation drivers studied since the developmental trajectory of oviparous animals is directly affected by environmental conditions. In the last decades, global warming predictions have aroused interest in understanding its impacts on biodiversity. It is predicted that the effects of direct warming will be exacerbated by other anthropogenic factors, such as microclimatic edge effects. Although the Brazilian Cerrado biome is one of the most affected by these issues, little is known about the aforementioned effects on its biodiversity. Therefore, the aim of our study is to investigate the influence of incubation temperature on developmental parameters, morphology and thermal physiology traits of the collared lizard (Tropidurus torquatus). Furthermore, we discuss our findings regarding lizard developmental biology and the climate change paradigm. Therefore, we incubated T. torquatus eggs under five temperature regimes ranging from artificial nest temperature (28.7 °C) to 35.0 °C. We found that elevated incubation temperatures affect several investigated traits: egg mass gain is positively affected, without any influence in newborn mass; incubation period is broadly reduced with temperature increase; survival rate is negatively affected by temperature, constant 35.0 °C regime is confirmed as a lethal incubation temperature, and the sex ratio is affected at 30.0 °C, with a prevailing outbreak of females. Increased incubation temperature also affects body and head size but has no effect on limb size. Newborn thermoregulation and the critical thermal maximum (CTmax) are not affected by incubation temperature. On the other hand, basal body temperature (Tbb) and the critical thermal minimum (CTmin) were positively affected. Thermal physiology was also affected by age, with newborns differing from adults for all analyzed thermal traits. Our findings indicate that future modifications in incubation temperature regimes at nesting sites caused by warming may affect several features of the development, morphology, and thermal physiology of newborns of this species. Laboratory experiments have pointed to possible drastic effects of warming on lizard survival rates, also affecting aspects of its natural history and population distribution. Moreover, in addition to being more vulnerable than adults in aspects such as predation and feeding, T. torquatus newborns are also more vulnerable regarding thermal physiological traits.
Health state utilities of patients with hepatitis B and C and hepatitis-related conditions in Japan
Authors: Sugimori Hiroki , Hirao Maki , Igarashi Ataru , Yatsuhashi Hiroshi , Ikeda Shunya , Masaki Naohiko , Yotsuyanagi Hiroshi , Yoda Takeshi , Odajima Takeshi , Takura Tomoyuki , Hirao Tomohiro 
Published: October 2022

AbstractHealth state utilities are global measurements of quality of life and have been used to evaluate health outcomes for the cost-utility analysis. This study aimed to estimate the health state utilities of patients with hepatitis B (HB), hepatitis C (HC), and hepatitis-related diseases in Japan. We distributed a self-administered questionnaire, including the EuroQol 5-Dimension 5-Level (EQ-5D-5L), to 9,952 outpatients with several clinical conditions caused by HB or HC virus infection (such as asymptomatic chronic hepatitis, chronic hepatitis, compensated cirrhosis, and decompensated cirrhosis) and estimated the condition-specific utilities of patients with HB or HC. In patients with more severe conditions (patients with acute hepatitis, fulminant hepatitis, and hepatocellular carcinoma and patients undergoing post-liver transplantation), the utilities of these severe conditions were estimated by three hepatitis experts using the EQ-5D-5L. The means of the utilities for acute hepatitis, fulminant hepatitis, asymptomatic chronic hepatitis, chronic hepatitis, compensated cirrhosis, compensated cirrhosis, hepatocellular carcinoma stage I/II, hepatocellular carcinoma stage III/IV, and post-liver transplantation were 0.529, − 0.111, 0.904, 0.868, 0.845, 0.722, 0,675, 0,428, and 0.651 and 0.876, 0.821, 0.737, 0.671, 0.675, 0.428, and 0.651 in HB and HC, respectively. To the best of our knowledge, this is the first study that comprehensively assessed the health state utilities of patients with HB, HC and hepatitis-related conditions from a nationwide survey in Japan using the EQ-5D-5L.
MED1, a novel binding partner of BRCA1, regulates homologous recombination and R-loop processing
Authors: Honjoh Harunori , Tanikawa Michihiro , Wada-Hiraike Osamu , Oda Katsutoshi , Inaba Hirofumi , Kukita Asako , Kawata Yoshiko , Kusakabe Misako , Tsuchimochi Saki , Taguchi Ayumi , Miyamoto Yuichiro , Sone Kenbun , Tsuruga Tetsushi , Mori-Uchino Mayuyo , Matsumoto Yoko , Osuga Yutaka 
Published: October 2022

AbstractHomologous recombination (HR) is a major repair pathway of DNA double-strand breaks and is closely related to carcinogenesis. HR deficiency has been established as a therapeutic target. The aim of this study was to elucidate the functions of a novel HR factor, Mediator complex subunit 1 (MED1), and its association with BRCA1. Formation of the MED1/BRCA1 complex was examined by immunoprecipitation and GST-pull down assays. The transcription cofactor role of BRCA1 was evaluated using luciferase assays. The roles of MED1 on DNA damage response and HR were analyzed by immunofluorescence and HR assays. R-loop accumulation was analyzed using immunofluorescence. R-loop-induced DNA damage was analyzed by comet assays. Immunoprecipitation and GST-pull down assays demonstrated that MED1 is a novel binding partner of BRCA1 and binds to the BRCT domain. Luciferase assays showed that MED1 potentiated the transcription ability of BRCT by two-fold. In MED1-depleted cells, recruitment of HR genes, such as RPA and γH2AX, to DNA damage sites was severely impaired. HR assays showed that MED1 knockdown significantly decreased HR activity. R-loop nuclear accumulation and R-loop-induced comet tails were observed in MED1-depleted cells. We conclude that the transcription factor MED1 contributes to the regulation of the HR pathway and R-loop processing.
Dissipation of field-aligned currents in the topside ionosphere
Authors: Giannattasio Fabio , Consolini Giuseppe , Coco Igino , De Michelis Paola , Pezzopane Michael , Pignalberi Alessio , Tozzi Roberta 
Published: October 2022

AbstractField-aligned currents (FACs) are electric currents parallel to the geomagnetic field and connecting the Earth’s magnetosphere to the high-latitude ionosphere. Part of the energy injected into the ionosphere by FACs is converted into kinetic energy of the surrounding plasma. Such a current dissipation is poorly investigated, mainly due to the high electrical conductivity and the small electric field strength expected in direction parallel to the geomagnetic field. However, previous results in literature have shown that parallel electric field is not null (and may be locally not negligible), and that parallel electrical conductivity is high but finite. Thus, dissipation of FACs may occur. In this work, for the first time, we show maps of power density dissipation features associated with FACs in the topside ionosphere of the Northern hemisphere. To this aim, we use a 6-year time series of data at one second cadence acquired by the European Space Agency’s “Swarm A” satellite flying at an altitude of about 460 km. In particular, we use data from the Langmuir probe together with the FAC product provided by the Swarm team. The results obtained point out that dissipation of FACs, even if small when compared to that associated with horizontal currents flowing about 350 km lower, is not null and shows evident features co-located with electron temperature at the same altitude. In particular, power density dissipation features are enhanced mainly in the ionospheric regions where intense energy injection from the magnetosphere occurs. In addition, these features depend on geomagnetic activity, which quantifies the response of the Earth’s environment to energetic forcing from magnetized plasma of solar origin.
Obesity-related measures and successful ageing among community-dwelling older adults in India: a cross-sectional study
Authors: Muhammad T. , Balachandran Arun , Kumar Pradeep , Srivastava Shobhit 
Published: October 2022

AbstractObesity is a chief lifestyle disease globally and causes a significant increase in morbidities. Overweight/ obesity prevalence has been rising faster in India compared to the world average. Therefore, the study examined the association between overweight/ obesity and successful ageing among older population in India. We also explored the gender difference in risks posed by obesity on successful ageing and the different socio-economic correlates associated with successful ageing. This study utilized data from India’s first nationally representative longitudinal ageing survey (LASI-2017-18). The effective sample size for the present study was 31,464 older adults with a mean age of 69.2 years (SD: 7.53). Overweight/ obesity was defined as having a body mass index of 25 or above. The study carried out a bivariate analysis to observe the association between dependent and independent variables. Further, multivariable analysis was conducted to examine the associations after controlling for individual socio-demographic, lifestyle and household/community-related factors. The study included 47.5% men and 52.5% women. It was found that the prevalence of obesity/overweight was higher among older women compared to older men (23.2% vs 15.5%). Similarly, high-risk waist circumference (32.7% vs 7.9%) and high-risk waist-hip ratio (69.2% vs 66.5%) were more prevalent among older women than older men. The study found significant gender differences (men-women: 8.7%) in the prevalence rate of successful ageing (p < 0.001). The chances of successful ageing were significantly higher among older adults who were not obese/overweight [AOR: 1.31; CI 1.31–1.55], had no high-risk waist circumference [AOR: 1.41; CI 1.29–1.54], and those who had no high-risk waist-hip ratio [AOR: 1.16; CI 1.09–1.24] compared to their respective counterparts. Interaction results revealed that older women who were not obese/overweight had a lower likelihood of successful ageing compared to the older men who was not obese/overweight [AOR: 0.86; CI 0.80–0.93]. Similarly, older womens who had no high-risk waist circumference [AOR: 0.86; CI 0.80–0.96] and no high risk-hip ratio [AOR: 0.81; CI 0.73–0.89] were less likely to have successful ageing compared to their counterparts, respectively. Being overweight/ obese and having high-risk waist circumference and waist-hip ratio were found to be significant factors associated with less successful ageing among older adults, especially women in this study. The current findings highlight the importance of understanding the modifiable factors, including nutritional awareness and developing targeted strategies for promoting successful ageing.
Pax3 loss of function delays tumour progression in kRAS-induced zebrafish rhabdomyosarcoma models
Authors: Kahsay A. , Rodriguez-Marquez E. , López-Pérez A. , Hörnblad A. , von Hofsten J. 
Published: October 2022

AbstractRhabdomyosarcoma is a soft tissue cancer that arises in skeletal muscle due to mutations in myogenic progenitors that lead to ineffective differentiation and malignant transformation. The transcription factors Pax3 and Pax7 and their downstream target genes are tightly linked with the fusion positive alveolar subtype, whereas the RAS pathway is usually involved in the embryonal, fusion negative variant. Here, we analyse the role of Pax3 in a fusion negative context, by linking alterations in gene expression in pax3a/pax3b double mutant zebrafish with tumour progression in kRAS-induced rhabdomyosarcoma tumours. Several genes in the RAS/MAPK signalling pathway were significantly down-regulated in pax3a/pax3b double mutant zebrafish. Progression of rhabdomyosarcoma tumours was also delayed in the pax3a/pax3b double mutant zebrafish indicating that Pax3 transcription factors have an unappreciated role in mediating malignancy in fusion negative rhabdomyosarcoma.
Emotional prosody recognition enhances and progressively complexifies from childhood to adolescence
Authors: Filippa M. , Lima D. , Grandjean A. , Labbé C. , Coll S. Y. , Gentaz E. , Grandjean D. M. 
Published: October 2022

AbstractEmotional prosody results from the dynamic variation of language’s acoustic non-verbal aspects that allow people to convey and recognize emotions. The goal of this paper is to understand how this recognition develops from childhood to adolescence. We also aim to investigate how the ability to perceive multiple emotions in the voice matures over time. We tested 133 children and adolescents, aged between 6 and 17 years old, exposed to 4 kinds of linguistically meaningless emotional (anger, fear, happiness, and sadness) and neutral stimuli. Participants were asked to judge the type and intensity of perceived emotion on continuous scales, without a forced choice task. As predicted, a general linear mixed model analysis revealed a significant interaction effect between age and emotion. The ability to recognize emotions significantly increased with age for both emotional and neutral vocalizations. Girls recognized anger better than boys, who instead confused fear with neutral prosody more than girls. Across all ages, only marginally significant differences were found between anger, happiness, and neutral compared to sadness, which was more difficult to recognize. Finally, as age increased, participants were significantly more likely to attribute multiple emotions to emotional prosody, showing that the representation of emotional content becomes increasingly complex. The ability to identify basic emotions in prosody from linguistically meaningless stimuli develops from childhood to adolescence. Interestingly, this maturation was not only evidenced in the accuracy of emotion detection, but also in a complexification of emotion attribution in prosody.
Epidemiology, clinical features, therapeutic interventions and outcomes of mucormycosis in Shiraz: an 8-year retrospective case study with comparison between children and adults
Authors: Motamedi Marjan , Golmohammadi Zahra , Yazdanpanah Somayeh , Saneian S. Mojtaba , Shafiekhani Mojtaba 
Published: October 2022

AbstractMucormycosis is an invasive fungal infection with high morbidity and mortality rate despite the early diagnosis and proper therapeutic interventions. Given the importance of epidemiological data in reviewing the attitude toward infectious diseases in developing countries, the current retrospective case study aimed to compare the epidemiological aspects, risk factors, clinical characteristics, therapeutic interventions, and outcomes of mucormycosis between adults and children during eight years (2013–2021) in the main infectious disease referral centers in the southwest of Iran. The median age of 164 patients included in this study was 47 years (IQR 22–59). The median length of hospitalization was 33 days.The annual incidence of mucormycosis-related hospitalizations was estimated 1.76 per 10,000 admissions during the study period. Moreover, the incidence of infection was 2.4 times higher in males than females in children. Diabetes mellitus was the most frequent predisposing factor in adults (46.0%). The main risk factor in children was hematologic malignancy (52.6%), but a considerable proportion of them (28.9%) were immunocompetent.The most frequent antifungal agent used was liposomal amphotericin B (82.3%) as monotherapy. The combination therapy was used more in adults (15.8%) than children (7.9%). In addition, surgical intervention with antifungal therapy was considered the most effective therapeutic approach. The in-hospital mortality rate was 14.6% for adults, whereas it was zero for children. Our findings provide a recent epidemiologic analysis of mucormycosis among hospitalized patients in both children and adults. Mucormycosis mainly affects individuals with diabetes mellitus or hematological malignancies and presents as rhino-orbito-cerebral form. Proven diagnosis of mucormycosis according to clinical manifestations and histopathology observations accompanied by proper antifungal treatments may improve survival rates.
Intermittent hypoxia inhibits epinephrine-induced transcriptional changes in human aortic endothelial cells
Authors: Cetin-Atalay Rengul , Meliton Angelo Y. , Sun Kaitlyn A. , Glass Mariel E. , Woods Parker S. , Peng Ying-Jie , Fang Yun , Hamanaka Robert B. , Prabhakar Nanduri R. , Mutlu Gökhan M. 
Published: October 2022

AbstractObstructive sleep apnea (OSA) is an independent risk factor for cardiovascular disease. While intermittent hypoxia (IH) and catecholamine release play an important role in this increased risk, the mechanisms are incompletely understood. We have recently reported that IH causes endothelial cell (EC) activation, an early phenomenon in the development of cardiovascular disease, via IH-induced catecholamine release. Here, we investigated the effects of IH and epinephrine on gene expression in human aortic ECs using RNA-sequencing. We found a significant overlap between IH and epinephrine-induced differentially expressed genes (DEGs) including enrichment in leukocyte migration, cytokine-cytokine receptor interaction, cell adhesion and angiogenesis. Epinephrine caused higher number of DEGs compared to IH. Interestingly, IH when combined with epinephrine had an inhibitory effect on epinephrine-induced gene expression. Combination of IH and epinephrine induced MT1G (Metallothionein 1G), which has been shown to be highly expressed in ECs from parts of aorta (i.e., aortic arch) where atherosclerosis is more likely to occur. In conclusion, epinephrine has a greater effect than IH on EC gene expression in terms of number of genes and their expression level. IH inhibited the epinephrine-induced transcriptional response. Further investigation of the interaction between IH and epinephrine is needed to better understand how OSA causes cardiovascular disease.
Changes in the deep vasculature assessed using anterior segment OCT angiography following trabecular meshwork targeted minimally invasive glaucoma surgery
Authors: Okamoto Yoko , Akagi Tadamichi , Kameda Takanori , Suda Kenji , Miyake Masahiro , Ikeda Hanako Ohashi , Numa Shogo , Tsujikawa Akitaka 
Published: October 2022

AbstractThe effect of trabecular meshwork (TM)-targeted minimally invasive glaucoma surgery (MIGS) on the vasculature assessed using anterior segment (AS)-optical coherence tomography angiography (OCTA) has not been established. In this prospective, longitudinal study, we investigated changes in the deep vasculature following TM-targeted MIGS using AS-OCTA for open-angle glaucoma in 31 patients. AS-OCTA images of the sclera and conjunctiva at the nasal corneal limbus were acquired preoperatively and 3 months postoperatively, and the vessel densities (VDs) of the superficial (conjunctival) and deep (intrascleral) layers were calculated. The VDs before and after MIGS were compared, and the factors associated with the change in VD following MIGS were analyzed. The mean deep VD decreased from 11.98 ± 6.80% at baseline to 10.42 ± 5.02% postoperatively (P = 0.044), but superficial VD did not change (P = 0.73). The multivariate stepwise regression analysis revealed that deep VD reduction was directly associated with IOP reduction (P < 0.001) and preoperative IOP (P = 0.007) and inversely associated with preoperative deep VD (P < 0.001). The deep VD reduction following MIGS was significant in the successful group (21 eyes) (P = 0.032) but not in the unsuccessful group (10 eyes) (P = 0.49). The deep VDs assessed using AS-OCTA decreased following TM-targeted MIGS, especially in the eyes with good surgical outcomes.
Design of piecewise deformed elliptical gear with closed pitch curve and its conjugate pair
Authors: Liu Youyu , Lu Songsong , Xu Jiao , Yang Siyang , Tao Wanbao 
Published: October 2022

AbstractThe family of elliptical gears with closed pitch curves includes elliptical gears and deformed elliptical gears. Elliptical gears are not only the most widely used non-circular gears but also the research hotspot in the field of non-uniform transmission. However, adjusting the shape of its pitch curve is difficult, which seriously restricts its popularization. This article proposes a piecewise deformed elliptical gear with a closed pitch curve, which realizes the unity of all kinds of elliptical gears in the mathematical model, makes the shape of the pitch curve and gear ratio easier to adjust, and expands the connotation and application scope of the family of elliptical gears. Moreover, the design approach of transmission with piecewise deformed elliptical gear was studied, and the inspection method of transmission performance was provided. The internal relationship between piecewise deformed elliptical gears and the family of elliptical gears was then analyzed. Finally, the method of computer-aided design (CAD) system developed was also provided. Additionally, a case was provided to verify the above theories. The designed conjugate pair can realize a correct meshing and adjust the gear ratio more flexibly, laying a theoretical foundation to expand the application field of non-uniform transmission.