bluuebunny/crossref_metadata_2025_split huggingface dataset:
Immunosuppressive Effect of Methanol Extract and Ethyl Acetate Fraction of Breadfruit [Artocarpus altilis (Park.) Fosberg] Leaves
Authors: Palupi Dwi Hadi Setya , Soemardji Andreanus A. , Iwo Maria Immaculata 
Published: October 2022

Background: Artocarpus sp. contained a variety of flavonoids, some of which have been shown to reduce inflammation. In vitro anti-inflammatory activity of breadfruit (Artocarpus altilis (Park.) Fosberg) has been demonstrated. Chronic inflammation can occur when immune defence mechanisms are activated by inflammatory conditions. Objectives: This study examined breadfruit leaf methanol extract and ethyl acetate fraction immunosuppressive effects. Material and Methods: The bioactive compounds in breadfruit leaves were extracted in methanol via maceration and fractionation in ethyl acetate via liquid-liquid extraction. The in vivo immunosuppressive effect was evaluated in male Swiss albino mice by humoral antibody titer, delayed-type hypersensitivity, and phagocytic index assays. Results: According to phytochemical screening, flavonoids and steroids were found in the extract and its ethyl acetate fraction. The breadfruit leaf extract and fraction showed an immunosuppressive effect through phagocytic index<1, and the thymus gland index was significantly decreased (p<0.05) compared to control. The breadfruit leaf extract and the ethyl acetate fraction were able to inhibit the production of antibodies and DTH reactions, two types of immune responses. Conclusions: The extract of breadfruit leaves and the ethyl acetate fraction showed immunosuppressive properties.
Endometrial cancer ProMisE classification predicts the risk of lymph node metastasis and prognosis
Authors: Li Qian , Zhang Xin 
Published: October 2022

Objective:To assess the correlation between ProMisE classification and
lymph node metastasis(LNM) of endometrial carcinoma(EC). Design:A
retrospective cohort study. Setting:Department of gynecologic oncology
at Liaoning Cancer Hospital in China. Population:From January 1st,2014
to December 31st, 2018,a total of 74 women with EC were included.32
cases had pelvic or para-aortic LNM and 42 cases had no LNM. Methods:The
formalin-fixed paraffin-embedded(FFPE) tissue sections of EC patients
were analyzed by the Proactive Molecular Risk Classifier
for Endometrial cancer (ProMisE) classification,and to evaluate the
correlation between ProMisE classification and LNM and prognosis of the
patients receiving different postoperative adjuvant therapies. Main
outcome measure:Correlation between ProMisE classification and
LNM,Overall Survival(OS) and progression-free survival(PFS). Results: In
the ProMisE classification,mismatch repair deficient(MMRd) was linked to
low pathological grade (p value=0.006; correlation=-0.315), p53 abnormal
subtype(p53abn) was correlated with LNM (p value=0.0004;
correlation=-0.472) and late International Federation of Gynecology and
Obstetrics (FIGO) stage (p value=0.005; correlation=-0.386).The 5-year
overall survival was 100% in Polymerase Epsilon exonuclease domain
mutated(POLE EDM), 85% in MMRd, 91.2% in p53 wild-type(p53wt) and
83.3% in p53abn.The 5-year PFS was 100% in POLE EDM, 95% in MMRd,
94.1% in p53wt and 77.8% in p53abn.We also found no statistical
difference in patients‘ benefits from Radiotherapy(RT) alone and
concurrent chemoradiotherapy(CCRT) in different molecular
subtypes,however,the patients had a trend toward benefit from CCRT in
the p53abn subtype. Conclusions:ProMisE classification can predict the
risk of LNM,histological grade,clinical staging and prognosis, which is
expected to guide the postoperative adjuvant treatment of EC patients.
Highly sensitive strain sensor based on microfiber coupler for wearable photonics healthcare
Authors: Gan Jiulin , Wang Xin , Zhou Hongyou , Chen Meihua , He Yongcheng , Zhang Zhishen , Yang Zhongmin 
Published: October 2022

High sensitivity flexible strain sensors that can perceive and respond
to strain stimulation are an essential part of wearable smart devices.
Yet, the detection of subtle strains on the human body and external
stimulation suffers from low sensitivity and slow response of many
existing sensors. Here, an ultrasensitive flexible optical sensor based
on microfiber coupler encapsulated by Polydimethylsiloxane (PDMS) has
been proposed to realize weak strain detection and fast response.
Benefiting from dramatic change of coupling ratio (CR) of the microfiber
coupler under weak strain, this flexible strain sensor exhibits
ultrahigh strain sensitivity (gauge factor, GF=900), low detection limit
of 0.001%, ultrafast response time (< 0.167 ms), and superior
durability and stability (>10 000 cycles). Synchronously,
the simultaneous detection of CR and loss parameters not only realizes
the 0.001% low detection limit, but also expands the sensing range to
0.45%. This highly sensitive microfiber coupler sensor has been
demonstrated to capture and recognize respiration, broadband sound
signals and pulse waves at different sites of human body in real time.
Moreover, based on frequency division multiplexing technology, the wrist
pulse and human voice could be detected and demodulated simultaneously.
This flexible photonics strain sensor could be useful in the development
of convenient and wearable healthcare devices.
Corresponding author(s) Email:
msgan@scut.edu.cn；zhangzs@fosu.edu.cn;
Pelatihan Online Psikologi Positif Berbasis Nilai Islam untuk Meningkatkan Resiliensi Mahasiswa
Authors: Hapsari Dian Kusuma , Karyani Usmi , Hertinjung Wisnu 
Published: October 2022

Abstract. University students are vulnerable to psychological problems, including Muslim university students. One of the reasons is the low resilience level. Therefore, an intervention is needed to develop the resilience of Muslim students so that it is expected to face difficulties and at the same time encourage self-development to protect students from psychological problems. The intervention will be better if it is adjusted to the values held by students, one of which is religious values. However, psychological interventions based on religious values to increase student resilience have not been developed much. This study aims to examine the effect of Islamic-based positive psychology online training on the improvement of university students’ resilience. The training modules were prepared based on the positive psychology intervention techniques and integrated with Islamic values. The training consists of six sessions and was delivered via Zoom meeting. This study employed a quasi-experiment with a one-group design pretest-posttest. The target participants of this study were Muslims students of the Universitas Muhammadiyah Surakarta. Participants who took part in this study received information that was announced through several social media. The study participants were 10 Universitas Muhammadiyah Surakarta students. The Connor-Davidson Resilience Scale (CD-RISC) was used to measure the resilience in Universitas Muhammadiyah Surakarta’s students. The data were analyzed using repeated-measures ANOVA and the results showed the scores of p = 0.005 (p 0.05). This result showed that online positive psychological training with Islamic values improves the university students’ resilience. Online positive psychology training based on Islamic can be used for promotive programs to improve Muslim students' mental health in Indonesia.Keywords: Islamic values; online training; positive psychology; resilience; university students
Relaxin inhibits 177Lu-EDTMP associated cell death in osteosarcoma cells through notch-1 pathway
Authors: Xu Junhua , Wan Song , Chen Wei , Zhang Yi , Ji Zhenzhong 
Published: October 2022

Abstract

177Lu-EDTMP (Ethylenediamine tetramethylene phosphonic acid) is the most used radioactive agent for pain palliation in bone cancer patients. The present study aims to study the impact of relaxin-2 on the 177Lu-EDTMP associated cell toxicity and death in osteosarcoma cells. MG63 and Saos-2 cells were cultured with 177Lu-EDTMP (37 MBq) for 24 h with and without pretreatment of recombinant relaxin 2 (RLXH2) for 12 and 24 h. 177Lu-EDTMP associated cellular deterioration and death was determined by LDH, MTT, and trypan blue dye assays. ELISA-based kit was used to determine apoptotic DNA fragmentation. Western blotting was used to determine expression levels of apoptotic-related signalling pathway proteins like bcl2, poly(ADP-ribose) polymerase (PARP), and MAPK (mitogen-activated protein kinase). Our results found that RLXH2 counters 177Lu-EDTMP associated cellular toxicity. Similarly, RLXH2 was able to counter 177Lu-EDTMP induced cell death in a concentration and time--dependent manner. Furthermore, it was found that RLXH2 treatment prevents apoptosis in 177Lu-EDTMP challenged cells through activation of the notch-1 pathway in a concentration- and time-dependent manner. We reported that RLXH2 significantly declined cellular toxicity and apoptosis associated with 177Lu-EDTMP in MG63 and Saos-2 cells through the notch-1 pathway.
Direct oral anticoagulants (DOACs): From the laboratory point of view
Authors: Margetić Sandra , Goreta Sandra Šupraha , Ćelap Ivana , Razum Marija 
Published: October 2022

Abstract
Direct oral anticoagulants (DOACs) represent a new generation of drugs that have been increasingly used in the prevention and treatment of thromboembolic states. According to the mechanism of anticoagulant action, DOACs are divided into two groups: direct inhibitors of thrombin (dabigatran) and direct inhibitors of activated factor X (FXa) (rivaroxaban, apixaban, edoxaban, betrixaban). Compared to the vitamin K antagonists, DOACs are superior in terms of onset of action, pharmacokinetic and pharmacodynamics properties and fixed daily dose without the need for routine coagulation monitoring. Despite these advantages, there are clinical conditions in which laboratory measurement of DOACs should be performed. Although DOACs have an impact on screening haemostasis assays (prothrombin time, PT; activated partial thromboplastin time, aPTT; and thrombin time, TT), these tests are not appropriate for quantifying drug levels. Therefore, specific quantitative methods (LC-MS/MS as a gold standard method for all DOACs, coagulometric and chromogenic assays for dabigatran, and chromogenic anti-Xa assays with drug-specific calibrators for inhibitors of FXa) should only be used for determination of DOACs concentration. The aim of this review is to present all aspects of laboratory assessment of DOACs, including pre-analytical, analytical and post-analytical factors in the overall testing process with a special accent on the available specific quantitative methods for measurement of DOACs in circulation.
The impact of the COVID-19 pandemic on the personal finance - a comparative analysis of Poles and Slovaks
Authors: Waliszewski Krzysztof 
Published: October 2022

Abstract
The COVID-19 pandemic, due to its prevalence, has affected all spheres of socio-economic life, in particular household finances. The aim of the article is to present the impact of the pandemic on the financial situation of Poles and Slovaks who use robo-advisory services, including their financial behaviour and investments. The methodology of the article involves literature analysis, statistical data and the author’s own empirical survey. The empirical study aims to verify the research hypothesis: the COVID-19 pandemic influenced the personal finances of Poles and Slovaks who use robo-advice, although this impact was not the same in all areas of personal finance, nor in relation to investment plans after the pandemic. During the pandemic, most of the respondents had lower expenses, but in the future more than half of the respondents did not plan to change the amount of their expenses. Most of the surveyed people increased their savings during the pandemic. Poles more often admitted that they invested more during the pandemic, while more Slovaks than Poles invested the same amount during the pandemic. On the other hand, the Slovak respondents declared that after the pandemic they intend to invest greater sums than Poles indicated.
Morphological and Molecular Characterization of Tylenchorhynchus clarus Allen, 1955 and T. zeae Sethi & Swarup, 1968 (Rhabditida: Telotylenchidae) from Iraq
Authors: Jumaah Ahmed Malik , Azimi Sedighe 
Published: October 2022

Abstract
During a survey on the biodiversity of plant-parasitic nematodes in Misan province (southeast Iraq), Tylenchorhynchus clarus and T. zeae were discovered around the rhizosphere of sugarcane and pumpkin, respectively. The morphological and morphometric data were provided for the recovered species. The morphological characters of both populations are in agreement with the type populations and other populations of them. To the best of our knowledge, this is the first report of these two species from Iraq, and a first report of the association of T. zeae with pumpkin. Molecular phylogenetic analyses of the Iraqi populations of T. clarus and T. zeae using the D2–D3 expansion segments of 28S rDNA and internal transcribed spacer (ITS) rDNA sequences using Bayesian inference (BI), showed they form maximally supported clades with other sequences of both species.
The Influence of Financial Knowledge on Financial Behavior and Financial Satisfaction on Pelita Indonesia Students
Authors: Panjaitan Harry Patuan , Renaldo Nicholas , Suyono Suyono 
Published: October 2022

The 2020 pandemic situation caused more than 60 percent of dissatisfaction with the survey results to the current financial situation. From the same small survey, it was found 34 percent of respondents showed poor financial habits. This study aims to determine the effect of Financial Knowledge on Financial Behavior and Financial Satisfaction. The sample in this study was 246 people using purposive and convenience sampling techniques. Data processing using path analysis with a Bayesian approach. The results showed that there was a significant influence of Financial Knowledge on Financial Behavior, Financial Knowledge on Financial Satisfaction, and Financial Behavior on Financial Satisfaction. Improved Financial Knowledge, both directly and indirectly, will greatly impact on Financial Satisfaction and really needs to be improved. Central Bank can provide financial knowledge supplies to lecturers of certain subjects so that it can be passed on to students.
Keywords—Bayesian Approach; Behavior; Knowledge; Satisfaction
الحذف على التدرج في القرآن الكريم دراسة نقدية دلالية
Authors: Taha Hasan Ali 
Published: October 2022

الحذف هو ظاهرة من الظواهر اللغوية التي تشترك فيها اللغات الانسانية، وتظهر هذه الظاهرة في بعض اللغات أكثر من غيرها كما نراها في لغتنا العربية التي دائما تميل إلى الإيجاز والاختصار الذي يكسب العبارة قوة وثراءً في المعنى ويبعدها عن الثقل، بل عدَّ ابن جني هذه الظاهرة من شجاعة العربية التي يكون الحذف فيها بالحركة والكلمة والجملة والكلام وكل ذلك بدليل يدل على المحذوف، وللحذف في العربية أنواع منها حذف الاقتطاع، والاكتفاء، والاحتباك والاختزال، ومن أنواع الحذف التي ذكرها النحاة حذف التدرج وهو موضوع بحثنا ، وقد ذكر هذا النوع جملة من النحاة ونسبه ابن جني إلى أبي الحسن الأخفش وتابعه على ذلك العلماء من بعده وعدَّه ابن جني من ملاطفة الصنعة بَيْدَ أن النحاة قد اوجزوا الكلام فيه تنظيرا وتطبيقا، وكان عنوان البحث: (الحذف على التدرج في القرآن الكريم دراسة نقدية دلالية) وقد قسمت البحث على مقدمة وتمهيد وأربعة مباحث وخاتمة، ذكرت في التمهيد مفهوم الحذف في اللغة والاصطلاح، ومفهوم الحذف على التدرج وموقف النحويين منه.
والمبحث الأول كان بعنوان: المفعول به الذي اقيم المضاف إليه مقامه، والثاني: ضمير الصفة وهو من التوابع، والثالث: ما حذف فيه مضافان، والرابع: ما حذف فيه أكثر من مضافين، ثم خاتمة ذكرت فيها أهم النتائج التي توصلت إليها.
التعليم الإلكتروني في ظلّ انتشار جائحة كورونا – المنجزات والتحديات
Authors: Talib Khawlah.M. 
Published: October 2022

الهدف من هذه الدراسة كشف التغيرات المفاجئة على التعلم الإلكتروني كما أننا نعلم أنّ ملف التعلم الالكتروني لم يكن ولوقت قريب ضمن الاهتمامات الأولوية لإصلاح وتطوير المؤسسات التعليمية، لذا نهدف في الدرجة الأولى إلى إظهار سمات التعليم الإلكتروني لإدارة الأزمة بفاعلية تمكن المتعلمين من تلقي المعلومات والتفاعل مع العملية بنجاح أكبر، وتحديد المشاكل التي تقف حاجزاً دون الوصول إلى الأهداف المطلوبة، وما ايجابيات هذا النوع من التعليم.
Features of urban and rural settlement systems at the present stage
Authors: Быстрова Татьяна Юрьевна , Мазаев Григорий Васильевич 
Published: October 2022

В статье рассматриваются особенности городской и сельской систем расселения, показана разница их типов сложности, уровней стратифицированности и возможностей пространственного развития. Будучи неучтенными в полной мере, эти особенности не позволяют специалистам создать адекватные модели сельской системы расселения и препятствуют принятию эффективных решений по усилению устойчивости села. В статье выявлены типичные недочеты и перспективные направления исследований сельской системы расселения, показаны ее качественные отличия от городской системы расселения. Все это способно в дальнейшем помочь в практических действиях по усилению устойчивости сельского расселения в России.
The article discusses the features of urban and rural settlement systems, shows the difference in their types of complexity, levels of stratification and opportunities for spatial development. Being not fully taken into account, these features do not allow specialists to create adequate models of the rural settlement system and hinder decisions to strengthen the sustainability of the country side. The article reveals typical shortcomings and perspective research areas of the rural settlement system, shows its qualitative differences from the urban settlement system. All this points can further help in practical actions to strengthen the sustainability of rural settlement in Russia.
The metaphorical form of lotus in the design of public buildings
Authors: Нунех Антван , Макарова Татьяна Львовна 
Published: October 2022

В статье проводится иконографический анализ архитектурных работ, принимающих природный элемент лотос как символ азиатской культуры. В результате исследования выявлены факторы, которые играют значимую роль в семантической дифференциации представленных архитектурных объектов и в повышении уникальности дизайна каждого здания.
This article provides an iconographic analysis of architectural works that take the natural element lotus as a symbol of Asian culture. As a result of the study, factors were identified that play a significant role in the semantic differentiation of the presented architectural objects and in increasing the uniqueness of the design of each building.
ТЕХНОЛОГИЧЕСКИЕ АСПЕКТЫ ПРОИЗВОДСТВА ПРОТЕРТЫХ МАСС БЕЗ САХАРА НА ОСНОВЕ ПЛОДОВОГО И ЯГОДНОГО СЫРЬЯ АЛТАЙСКОГО СОРТИМЕНТА
Authors: Скороспелова Елена Владимировна , Михайлова Оксана Юрьевна , Шелковская Наталья Кирилловна 
Published: October 2022

Особенности технологии производства протертых масс без сахара из плодов алтайской селекции, выращенных в лесостепной зоне Алтайского края, не достаточно изучены. Многие вопросы технологии, а также разработка нормативно-технической документации на новый вид продуктов актуальны и имеют научную новизну. Протертая масса из плодов может быть использована как самостоятельный продукт или функциональный наполнитель для продуктов питания.Для приготовления протертых масс без сахара плоды подвергали инспекции, мойке, далее бланшировали, дробили и протирали через сито с диаметром ячеек 0,7-1,5 мм. Полученную массу уваривали, фасовали, пастеризовали при температуре 95°С, герметично укупоривали.Новые виды продуктов консервирования, полученные из жимолости и смородины черной, отличаются высокой кислотностью: 4,15-4,70 % в жимолостных и 3,00-3,40 % в черносмородиновых. Минимальное значение титруемой кислотности отмечено в продуктах из яблок – 1,02-1,14 %. Содержание сахаров в протертых массах колеблется от 6,6 до 11,8 г/100 г. Максимальное значение отмечено в протертых массах из яблок, минимальное – в образце из облепихи сорта Августина. Минимальное содержание полифенолов отмечено в яблочных протертых массах (171-174 мг/100 г), максимальное – в образцах из жимолости (604-830 мг/100 г). В облепиховых протертых массах содержание полифенолов 133-290 мг/100 г, в черносмородиновых 159-567 мг/100 г. Протертые массы без сахара по физико-химическому составу имеют существенные отличия по сортам.Разработаны ТИ и ТУ по производству протертых масс без сахара из плодово-ягодного сырья алтайской селекции.
ВЫДЕЛЕНИЕ, ХАРАКТЕРИСТИКА И ПЕРСПЕКТИВЫ ИСПОЛЬЗОВАНИЯ ПЕПТИДОВ МОЛОЗИВА КОРОВ
Authors: Тихонов Сергей Леонидович , Тихонова Наталья Валерьевна , Данилова Ирина Георгиевна , Ожгихина Анна Сергеевна , Тихонова Мария Сергеевна , Поповских Анжелика Денисовна 
Published: October 2022

Несмотря на большие успехи, достигнутые в создании пищевой продукции для профилактики алиментарнозависимых заболеваний, некоторые проблемы сохранения здоровья человека остаются без ответа. Развитие онкологических заболеваний, бактериальных и вирусных инфекций со множественной лекарственной устойчивостью по-прежнему представляет собой угрозу мирового значения. Альтернативой известным лекарственным препаратам и микронутриентам представляются природные биологически активные пептиды, обладающие широким спектром антимикробной, противоопухолевой, и иммуностимулирующей активностями. Цель исследований – выделение, характеристика и оценка перспектив использования пептидов трипсинового и пепсинового гидролизата молозива коров в производстве пищевой продукции специализированного назначения и лекарственных препаратов. Белковые фракции ферментативного гидролизата молозива коров исследовали на масс-спектрометре МАЛДИ-ТОФ, расшифровку проводили с помощью базы данных Mascot, опция Peptide Fingerprint («Matrix Science», США) с использованием базы данных Protein NCBI. В трипсиновом гидролизате молозива коров выделено 7 пептидов, в пепсиновом гидролизате – 9 пептидов. Выделенные пептиды характеризуются различной аминокислотной последовательностью, молекулярной массой и скором, различаются по физиологическим функциям в организме человека. Пептид «Dualspecificityproteinphosphatase» способен акти­визировать иммунныуй ответ, «NCI_CGAP_Brn23 Клонк ДНК Homo sapiens» обеспечивает нормальное развитие центральной нервной системы, пептид «BAMA» способен встраиваться во внешнюю мембрану бактерий, что позволяет его использовать как переносчик грузов в клетки организма для поддержания жизнедеятельности или борьбы с вирусными инфекциями, для подавления опухолевых клеток. Пептид «Nuclearreceptor 2C2-associatedprotein» препятствует возникновению рака. Функции других выделенных пептидов не изучены, что предполагает проведение исследований по оценке их биологической активности. Полученные данные позволяют предположить, что пептиды с доказанной фармакологической активностью после проведения дополнительных доклинических и клинических исследований можно использовать при разработке продуктов питания функциональной направленности и терапевтических средств широкого спектра действия
SUBJECTIVE NOTES ON LEGAL TERMS
Authors: Тарусина Надежда Николаевна 
Published: October 2022

Предлагаются размышления об этической некорректности, психологической дискомфортности либо небрежности, допускаемых российским законодателем при конструировании нормативно-правовых предписаний (при использовании терминов, терминологических конструкций, попытках дефинирования понятий). Образцы подобного рода обнаружены, в силу строго определенных научных интересов автора, в законодательстве социальной сферы - в широком ее значении (семейном, трудовом, страховом, медицинском). Среди прочего обращается внимание на своеобразные проявления при терминологическом обеспечении текстов гендерных стереотипов и неточностей.
The article offers reflections on ethical incorrectness, psychological discomfort or negligence allowed by the Russian legislator in the construction of legal regulations (when using terms, terminological constructions, attempts to define concepts). Samples of this kind were found, due to the strictly defined scientific interests of the author, in the legislation of the social sphere -in its broad meaning (family, labor, insurance, medical). Among other things, attention is drawn to the peculiar manifestations of gender stereotypes and inaccuracies in the terminological provision of texts.