bluuebunny/crossref_metadata_2025_split huggingface dataset:
O Uso do Karatê como recurso no processo reabilitatório de um paciente com sequelas de Acidente Vascular Cerebral (AVC): Um relato de experiência em Terapia Ocupacional
Authors: Silva Ewerling Cristina Reis da , Carvalho Amanda Alice de Lima , Costa Fabiola da Silva , Sá Nonato Márcio Custódio Maia , Lopes Junior Jorge Rodrigues 
Published: February 2022

O presente artigo objetiva relatar a experiência de discentes de Terapia Ocupacional na intervenção do caso de um paciente do sexo masculino, acometido de hemiplegia e hemiparesia decorrentes de dois acidentes vascular encenfálico. As intervenções ocorreram durante a prática de um componente curricular do 5º semestre do curso Terapia Ocupacional da Universidade do Estado do Pará (UEPA). O paciente foi selecionado da lista de espera de pacientes com demandas de sequelas neurológicas, traumato-ortopedia e doenças reumáticas, da Unidade de Fisioterapia e Terapia Ocupacional (UEAFTO). As sessões foram realizadas duas vezes por semana, com duração de 50 minutos, nos meses de agosto a novembro de 2021. Optou-se por intervir com modelos combinados como os princípios da Plasticidade Cerebral, Terapia de Restrição e Indução de Movimento e da técnica de terapia espelho. Nas intervenções, utilizou-se como recurso o Karatê, bem como adaptações para Atividades de Vida Diária (AVD), e adaptações auxiliares para execução de atividades nas seções de terapia ocupacional. O paciente apresentou entusiasmo e maior engajamento com a inclusão do karatê nas sessões de terapia ocupacional, ademais observou-se de forma empírica que o paciente apresentou ganho de Amplitude de Movimento nos Membros Superiores e Inferiores (MMSS/MMII), amenizou-se a ataxia apresentando maior estabilidade no MSE e ganho de força muscular. A combinação de abordagens e técnicas somada ao resgate de ocupações anteriores contribuíram para resultados positivos, além de aprimorar o raciocínio clínico e a experiência acadêmica das discentes.
Desenvolvimento do Hemomonitor com sistema de alertas para o paciente em uso de hemocomponentes
Authors: Silva Aline Bezerra , Silva Juliana de Oliveira Musse , Lima Viviane Nascimento Brandão , Silva Geydson Cruz da , Teles Isabella Lima Dantas , Martins Júnior João Amaury Lima , Santos Neto Asclepíades José dos , Silva Ângela Maria da , Oliveira Adicinéia Aparecida de 
Published: February 2022

Objetivo: Desenvolver o módulo de software Hemomonitor com sistema de alertas para monitoramento dos pacientes em uso de hemocomponentes. Metodologia: Trata-se de uma pesquisa aplicada realizada em um Hospital Universitário, cuja trajetória metodológica seguiu três etapas: 1) Caracterização do processo transfusional no local do estudo; 2) Atualização acerca dos softwares disponíveis sobre o tema por meio de uma revisão de literatura; 3) Desenvolvimento de software atualizado com base na literatura especializada. Resultados: Os fluxos de atividades desempenhadas foram deflagrados a partir da extração de dados multivariados dos sistemas, AGHUx e +Exames, utilizados pela instituição, para transformá-los em informações. Além disso, visando seu funcionamento, foi necessário parametrizar as alterações dos exames laboratoriais, certificar a prescrição do HC com a assinatura do médico responsável pelo paciente, construir um sequenciamento de solicitação de HC, permitir o compartilhamento das informações e interfaceamento entre os setores, padronizar os exames comprobatórios mediante à suspeita transfusional, identificar a amostra do paciente e da bolsa do HC de forma apropriada com a legislação, parametrizar os laudos para as provas de compatibilidade, permitir a rastreabilidade, parametrizar alterações dos sinais vitais para estabelecer vínculo temporal, definir as trilhas de auditoria, capacitar as equipes quanto à celeridade dos processos, eficiência e aproveitamento substancial dos recursos. Conclusão: A implementação do módulo Hemomonitor e a aplicação em uma unidade piloto permitiu observar que a sua utilização pode melhorar a monitorização e acompanhamento em tempo real dos pacientes em uso de HC, auxiliando na antecipação de condutas eficazes para mitigação das RT.
Salmonella spp. in non-edible animal products intended for the preparation of feed (meal) for industrial poultry feed
Authors: Costa Wellington Luis Reis , Santos Emília Turlande Sêneca Ribeiro dos , Leal Neto Antenor Ferreira , Silva Rebeca Ayala Rosa da , Rodgers Moara de Santana Martins , Fernandes Lia Muniz Barretto , Nascimento Elmiro Rosendo do 
Published: February 2022

Non-edible by-products of animal origin are slaughter waste from slaughter animals that after processing give rise to animal meal which in turn is used as ingredients in the preparation of animal feed such as farm animals. Although this practice has its advantages in reducing environmental impact and meeting the nutritional needs of animals, it can serve as a vehicle for microorganisms such as Salmonella spp. Since food can play an important role in the dissemination of pathogens in the poultry production chain through feeding, the objective of the present study was to investigate the presence of Salmonella spp. samples of non-edible flours of animal origin used in the formulation of feed and also of feed produced from these by-products in slaughterhouses received from Bahia and Pernambuco states, Brazil and that are used in the industrial poultry farms of these States. Out of 649 samples of animal origin flours and feed were analyzed, of which 110 (16.9%) presented Salmonella spp. Statistical analysis, through descriptive analysis and Pearson’s chi-squase association test (X2) showed an association between the presence of Salmonella spp. and the different types of inedible foods analyzed (p<0.05).This contamination in the analyzed samples indicates failure in the microbiological control during and/or after processing of animal origin flours, making them the sources of pathogen dissemination in the poultry chain.
O ensino de bioquímica da respiração celular facilitado por aplicativo para aparelho celular.
Authors: Santos Antonio Delmário Alves dos , Santos Pablo de Castro , Marques Regina Célia Pereira 
Published: February 2022

As Tecnologias da Informação e da Comunicação – TICs, trazem novas possibilidades para o ensino e para a aprendizagem de temas próprios da Bioquímica. O ensino híbrido e as metodologias ativas, associados as ferramentas tecnológicas educacionais, podem determinar a quebra de paradigmas no âmbito do fazer pedagógico. Para analisar as relações entre ensino híbrido e a metodologia ativa sala de aula invertida, este trabalho utilizou o aplicativo Bio Respiração, uma ferramenta de ensino para facilitar o ensino da respiração celular. A utilização de questionários específicos sobre o ensino da respiração celular a partir do uso da ferramenta mencionada e a análise dos mesmos, caracterizou os seus aspectos quantitativos e qualitativos. Alunos e professores da rede pública da região metropolitana de Fortaleza/Ce, constituíram o grupo amostral. Os resultados obtidos demonstraram que a ferramenta testada, poderá auxiliar professores e alunos no ensino e na aprendizagem da respiração celular.
A contribuição da educação física escolar na formação social do indivíduo
Authors: Silva Alexandre Rodrigues da , Almeida Alexandra Tomaz de Sousa , Gois Odvan Pereira de , Nascimento Marcos Antônio Medeiros do , Souto Filho José Morais 
Published: February 2022

Introdução: A Educação Física é um importante campo de ensino e aprendizagem, utiliza-se de conteúdo que contribui com o desenvolvimento e a formação social do aluno, oportunizando experiencias que auxiliam na formação do senso crítico reflexivo, respeito e a cooperação. Objetivo: Evidenciar a contribuição da Educação Física Escolar na formação social do indivíduo. Métodos: O estudo caracterizar-se como revisão sistemática. Para a elaboração da revisão sistemática, foi feito uma busca nos bancos de dados Scielo e Lilacs, sendo incluso artigos com bases nos critérios de inclusão. Resultados: Foram encontrados 56 artigos na primeira fase de busca. No seguimento foi realizada uma análise previa dos artigos encontrados empregando os critérios de inclusão e exclusão resultando em apenas 3 artigos incluído no estudo. Conclusão: A Educação Física possui uma relação entre o conhecimento tratado nas aulas e a compreensão em múltiplas dimensões sociais. Entretanto para o pleno desenvolvimento do estudante o professor de Educação Física deve estar comprometido com o real papel do processo educativo no âmbito escolar.
Qualification of the results of aggregated lean KPIs along fuzzy logic
Authors: Sándor Gáspár , Vajda Gábor , Martos Ede 
Published: February 2022

The application of lean management has become a fundamental competitive criterion in the operation of industrial enterprises in the 21st century. The use of tools and methods related to different lean management appears in a significant part of corporate functions. However, it is also important to mention that these lean tools and methods are used in addition to the mixed use of many other tools and methods that support non-lean goals. This problem is also a challenge for controlling. Because lean accounting methods do not necessarily measure the extent of lean effectively in such an environment, a number of other methods are used to monitor lean in both academic and business practice. Of these, lean evaluation models based on fuzzy logic should be highlighted. With the help of these models, it is possible to determine the lean performance of a company primarily along financial data. The disadvantage of the model, however, is that lean management also appears in a number of functional areas that cannot be assessed along financial ratios, but they clearly influence the operation of lean management.
In our research, we illustrated a complex set of lean controlling methods through an instrumental case study, which allows companies to evaluate the performance of lean management and to explore different points of intervention. Our research results make it possible to calculate the lean fuzzy index not only along financial data, and thus clarify the information content of the index. Along the methods and indicators formulated in our research, the effectiveness of lean methods and tools, as well as the processes and methods supporting lean goals, can be separated and measured. Our research goal is to create a generally applicable lean controlling conceptual model.
Platinum Nanocatalysts Supported on Defective Hollow Carbon Spheres: Oxygen Reduction Reaction Durability Studies
Authors: Mashindi Victor , Mente Pumza , Phaahlamohlaka Tumelo N. , Mpofu Nobuhle , Makgae Ofentse A. , Moreno Beatriz D. , Barrett Dean H. , Forbes Roy P. , Levecque Pieter B. , Ozoemena Kenneth I. , Coville Neil J. 
Published: February 2022

The durability and long-term applicability of catalysts are critical parameters for the commercialization and adoption of fuel cells. Even though a few studies have been conducted on hollow carbon spheres (HCSs) as supports for Pt in oxygen reduction reactions (ORR) catalysis, in-depth durability studies have not been conducted thus far. In this study, Pt/HCSs and Pt/nitrogen-doped HCSs (Pt/NHCSs) were prepared using a reflux deposition technique. Small Pt particles were formed with deposition on the outside of the shell and inside the pores of the shell. The new catalysts demonstrated high activity (&gt;380 μA cm−2 and 240 mA g−1) surpassing the commercial Pt/C by more than 10%. The catalysts demonstrated excellent durability compared to a commercial Pt/C in load cycling, experiencing less than 50% changes in the mass-specific activity (MA) and surface area-specific activity (SA). In stop-start durability cycling, the new materials demonstrated high stability with more than 50% retention of electrochemical active surface areas (ECSAs). The results can be rationalised by the high BET surface areas coupled with an array of meso and micropores that led to Pt confinement. Further, pair distribution function (PDF) analysis of the catalysts confirmed that the nitrogen and oxygen functional groups, as well as the shell curvature/roughness provided defects and nucleation sites for the deposition of the small Pt nanoparticles. The balance between graphitic and diamond-like carbon was critical for the electronic conductivity and to provide strong Pt-support anchoring.
Predictive Value of Echocardiographic Strain for Myocardial Fibrosis and Adverse Outcomes in Autoimmune Diseases
Authors: Jia Fuwei , Li Xiao , Zhang Dingding , Jiang Shu , Yin Jie , Feng Xiaojin , Zhu Yanlin , Liu Yingxian , Zhu Yuanyuan , Lai Jinzhi , Yang Huaxia , Fang Ligang , Chen Wei , Wang Yining 
Published: February 2022

BackgroundMyocardial fibrosis is an important pathophysiologic mechanism of cardiac involvement that leads to increased mortality in patients with autoimmune diseases (AIDs). The aim of this study was to evaluate the association between myocardial strain from speckle-tracking echocardiography (STE) and fibrosis on cardiovascular magnetic resonance (CMR) and to further explore their prognostic implications in patients with AIDs.MethodsWe prospectively included 102 AIDs patients with clinically suspected cardiac involvement and 102 age- and sex-matched healthy individuals. Patients underwent CMR for evaluation of myocardial fibrosis by late gadolinium enhancement (LGE) and T1 mapping. A semiquantitative evaluation based on the extent of LGE was used to calculate the total (tLGEs) and segmental (sLGEs) LGE score. Global longitudinal strain (GLS) was evaluated by STE in all subjects. All patients were regularly followed up every 6 months. The primary endpoint was the composite incidence of all-cause death and cardiovascular hospitalization.ResultsCompared to healthy controls, AIDs patients had impaired GLS (−17.9 ± 5.1% vs. −21.2 ± 2.5%, p &lt; 0.001). LGE was detected in 70% of patients. Patients with LGE presented worse GLS (−17.1 ± 5.3% vs. −19.6 ± 4.1%, p = 0.018) than those without LGE. On multivariate logistic analysis, GLS ≥ −15% was an independent predictor of LGE presence (OR = 4.98, 95%CI 1.35–18.33, p = 0.016). Moreover, a marked and stepwise impairment of segmental longitudinal strain (−19.3 ± 6.6 vs. −14.9 ± 6.5 vs. −8.9 ± 6.3, p &lt; 0.001) was observed as sLGEs increased. During a median follow-up time of 25 months, 6 patients died, and 14 patients were hospitalized for cardiovascular reasons. Both GLS ≥ −15% (HR 3.56, 95%CI 1.28–9.86, p = 0.015) and tLGEs ≥ 6 (HR 4.13, 95%CI 1.43–11.92, p = 0.009) were independently associated with the primary endpoint.ConclusionsIn AIDs patients, impaired myocardial strain on STE could reflect the presence and extent of myocardial fibrosis and provide incremental prognostic value in addition to LGE in the prediction of adverse outcomes.
Predictors of Near-Infrared Spectroscopy-Detected Lipid-Rich Plaques by Optical Coherence Tomography-Defined Morphological Features in Patients With Acute Coronary Syndrome
Authors: Usui Eisuke , Yonetsu Taishi , Ohmori Mari , Kanno Yoshinori , Nakao Masahiko , Niida Takayuki , Matsuda Yuji , Matsuda Junji , Umemoto Tomoyuki , Misawa Toru , Hada Masahiro , Hoshino Masahiro , Kanaji Yoshihisa , Sugiyama Tomoyo , Kakuta Tsunekazu , Sasano Tetsuo 
Published: February 2022

BackgroundNear-infrared spectroscopy (NIRS) provides the localization of lipid-rich components in coronary plaques. However, morphological features in NIRS-detected lipid-rich plaques (LRP) are unclear.MethodsA total of 140 de novo culprit lesions in 140 patients with the acute coronary syndrome (ACS) who underwent NIRS and optical coherence tomography (OCT) examinations for the culprit lesions at the time of percutaneous coronary interventions were investigated. We defined a NIRS-LRP as a lesion with a maximum lipid core burden index of 4 mm [LCBI4mm] &gt; 500 in the culprit plaque. Clinical demographics, angiographic, and OCT findings were compared between the patients with NIRS-LRP (n = 54) vs. those without NIRS-LRP (n = 86). Uni- and multivariable logistic regression analyses were performed to examine the independent OCT morphological predictors for NIRS-LRP.ResultsClinical demographics showed no significant differences between the two groups. The angiographic minimum lumen diameter was smaller in the NIRS-LRP group than in the non- NIRS-LRP group. In OCT analysis, the minimum flow area was smaller; lipid angle, lipid length, the prevalence of thin-cap fibroatheroma, and cholesterol crystals were greater in the NIRS-LRP group than in the non-NIRS-LRP group. Plaque rupture and thrombi were more frequent in the NIRS-LRP group, albeit not significant. In a multivariable logistic regression analysis, presence of thin-cap fibroatheroma [odds ratio (OR): 2.56; 95% CI: 1.12 to 5.84; p = 0.03] and cholesterol crystals (OR: 2.90; 95% CI: 1.20 to 6.99; p = 0.02) were independently predictive of NIRS-LRP.ConclusionsIn ACS culprit lesions, OCT-detected thin-cap fibroatheroma and cholesterol crystals rather than plaque rupture and thrombi were closely associated with a great lipid-core burden.
Thyroid Status During Pregnancy in Women With Polycystic Ovary Syndrome and the Effect of Metformin
Authors: Trouva Anastasia , Alvarsson Michael , Calissendorff Jan , Åsvold Bjørn Olav , Vanky Eszter , Hirschberg Angelica Lindén 
Published: February 2022

ObjectivePolycystic ovary syndrome (PCOS) and hypothyroidism are related conditions, and both are associated with adverse pregnancy outcomes. Knowledge is lacking about the complex interaction between thyroid status and PCOS during pregnancy. We investigated the thyroid status and its association with pregnancy complications in PCOS, and in relation to metformin treatment.DesignPost-hoc analyses of two randomized, double-blind, placebo-controlled trials.Methods288 pregnant women with PCOS were randomized to treatment with metformin or placebo from first trimester to delivery. We measured serum levels of thyroid stimulating hormone (TSH) and free thyroxine (fT4) at gestational week (gw) 5-12, 19, 32 and 36 and related to metformin treatment and pregnancy complications. Thyroid peroxidase antibodies (TPO-ab) were analyzed at inclusion and at gw 36.ResultsThe overall prevalence of subclinical and overt hypothyroidism was 1.5% and 0%, respectively. The TSH level was not affected by metformin, whereas fT4 was significantly higher in the metformin group with less decrease throughout pregnancy compared to placebo, p&lt;0.001. A lower decrease in fT4 during pregnancy correlated to less weight gain (r= -0.17, p=0.020) and tended to be associated with reduced odds ratio for gestational diabetes (OR 0.85 per 1 pmol/L, 95% CI 0.71;1.02).ConclusionsIn women with PCOS, metformin treatment during pregnancy was associated with less decrease in fT4 compared to placebo, while it did not affect TSH. A smaller decrease in fT4 correlated to less weight gain and tended to be associated with a lower risk of gestational diabetes.Clinical Trial RegistrationClinicalTrials.gov, identifier NCT00159536 (The PregMet study); identifier NCT03259919 (The pilot study).
Totoro: Identifying Active Reactions During the Transient State for Metabolic Perturbations
Authors: Galvão Ferrarini Mariana , Ziska Irene , Andrade Ricardo , Julien-Laferrière Alice , Duchemin Louis , César Roberto Marcondes , Mary Arnaud , Vinga Susana , Sagot Marie-France 
Published: February 2022

Motivation: The increasing availability of metabolomic data and their analysis are improving the understanding of cellular mechanisms and how biological systems respond to different perturbations. Currently, there is a need for novel computational methods that facilitate the analysis and integration of increasing volume of available data.Results: In this paper, we present Totoro a new constraint-based approach that integrates quantitative non-targeted metabolomic data of two different metabolic states into genome-wide metabolic models and predicts reactions that were most likely active during the transient state. We applied Totoro to real data of three different growth experiments (pulses of glucose, pyruvate, succinate) from Escherichia coli and we were able to predict known active pathways and gather new insights on the different metabolisms related to each substrate. We used both the E. coli core and the iJO1366 models to demonstrate that our approach is applicable to both smaller and larger networks.Availability:Totoro is an open source method (available at https://gitlab.inria.fr/erable/totoro) suitable for any organism with an available metabolic model. It is implemented in C++ and depends on IBM CPLEX which is freely available for academic purposes.
Strength Analysis and Optimization of Alkali Activated Slag Backfills Through Response Surface Methodology
Authors: Dai Xinghang , Ren Lei , Gu Xiaozhong , Yilmaz Erol , Fang Kun , Jiang Haiqiang 
Published: February 2022

The significant difference in water-to-binder ratio, activator type and concentration between alkali-activated slag (AAS) paste/mortar/concrete and AAS-based cemented paste backfill (AAS-CPB) means that previous results related to the properties and mix optimization of AAS materials cannot be directly translated to AAS-CPB. This study statistically identifies the effect of key influential variables such as silicate modulus, slag fineness and activator concentration on 3- and 28 day unconfined compressive strength (UCS) of AAS-CPB by central composite design (CCD) established in response surface methodology (RSM). In this study, the prominence of independent variables and their relations are investigated by using ANOVA (analysis of variance) having a significant level of 0.05. ANOVA results certify that there is a strong link between the level of variable contribution on UCS performance of AAS-CPB and curing age. Obviously, silicate modulus and activator concentration are the most major variables influencing UCS at 3 and 28 days, respectively. Increased fineness of slag and higher pH of pore solution enhance 3 day UCS, but restrain the further hydration of unreacted slag and subsequent the gain in strength at advanced curing ages. The combination of independent variables of silicate modulus (0.295), slag fineness (12630.2), activator concentration (0.45) gives the optimum responses.