bluuebunny/crossref_metadata_2025_split huggingface dataset:
Low power hardware design and its mathematical modeling for fast‐exact geolocalization system in wireless networks
Authors: zaidi Monji , Bouazzi Imen , Al‐Rayif Mohammed Ibrahim , Shamim Mohammed Zubair Mohammed , Usman Mohammed 
Published: February 2022

SummaryA significant goal in achieving position calculation is to reduce and simplify the instructions that the Mobile Station (MS) has to accomplish in the location determination algorithm. Standard techniques widely used in many applications can be classified into Received Signal Strength Indicator (RSSI), Angle of Arrival (AoA), Time Difference of Arrival (TDoA), and Time of Arrival (ToA). However, all are almost determined by the standard trigonometric complex computation methods that are usually implemented in software where the complexity is considerable. The development of a simple and efficient technique for MS location estimation is the main objective of this paper. To design a modern hardware‐oriented algorithm, a new approach using simple Add‐and‐Shift operations in the computation is proposed and it can be implemented in a hardware target. In order to accelerate the geopositioning process, the Coordinate Rotation Digital Computer (CORDIC) algorithm has been used in this proposal. The proposed algorithm is simpler and faster than conventional ones; thus, complexity in terms of time, power consumption, and chip area has been reduced. Therefore, the algorithm is suitable for applications with limited computational and power resources. Based on comparisons with the state‐of‐the‐art algorithms, it is concluded that the proposed technique is more exact and less complex.
A study of the longitudinal changes in multiple cerebrospinal fluid and volumetric magnetic resonance imaging biomarkers on converter and non‐converter Alzheimer's disease subjects with consideration for their amyloid beta status
Authors: Morar Ulyana , Izquierdo Walter , Martin Harold , Forouzannezhad Parisa , Zarafshan Elaheh , Unger Elona , Bursac Zoran , Cabrerizo Mercedes , Barreto Armando , Vaillancourt David E. , DeKosky Steven T. , Loewenstein David , Duara Ranjan , Adjouadi Malek 
Published: February 2022

AbstractIntroductionThis study aims to determine whether newly introduced biomarkers Visinin‐like protein‐1 (VILIP‐1), chitinase‐3‐like protein 1 (YKL‐40), synaptosomal‐associated protein 25 (SNAP‐25), and neurogranin (NG) in cerebrospinal fluid are useful in evaluating the asymptomatic and early symptomatic stages of Alzheimer's disease (AD). It further aims to shed new insight into the differences between stable subjects and those who progress to AD by associating cerebrospinal fluid (CSF) biomarkers and specific magnetic resonance imaging (MRI) regions with disease progression, more deeply exploring how such biomarkers relate to AD pathology.MethodsWe examined baseline and longitudinal changes over a 7‐year span and the longitudinal interactions between CSF and MRI biomarkers for subjects from the Alzheimer's Disease Neuroimaging Initiative (ADNI). We stratified all CSF (140) and MRI (525) cohort participants into five diagnostic groups (including converters) further dichotomized by CSF amyloid beta (Aβ) status. Linear mixed models were used to compare within‐person rates of change across diagnostic groups and to evaluate the association of CSF biomarkers as predictors of magnetic resonance imaging (MRI) biomarkers. CSF biomarkers and disease‐prone MRI regions are assessed for CSF proteins levels and brain structural changes.ResultsVILIP‐1 and SNAP‐25 displayed within‐person increments in early symptomatic, amyloid‐positive groups. CSF amyloid‐positive (Aβ+) subjects showed elevated baseline levels of total tau (tTau), phospho‐tau181 (pTau), VILIP‐1, and NG. YKL‐40, SNAP‐25, and NG are positively intercorrelated. Aβ+ subjects showed negative MRI biomarker changes. YKL‐40, tTau, pTau, and VILIP‐1 are longitudinally associated with MRI biomarkers atrophy.DiscussionConverters (CNc, MCIc) highlight the evolution of biomarkers during the disease progression. Results show that underlying amyloid pathology is associated with accelerated cognitive impairment. CSF levels of Aβ42, pTau, tTau, VILIP‐1, and SNAP‐25 show utility to discriminate between mild cognitive impairment (MCI) converter and control subjects (CN). Higher levels of YKL‐40 in the Aβ+ group were longitudinally associated with declines in temporal pole and entorhinal thickness. Increased levels of tTau, pTau, and VILIP‐1 in the Aβ+ groups were longitudinally associated with declines in hippocampal volume. These CSF biomarkers should be used in assessing the characterization of the AD progression.
Vascular risk profile and white matter hyperintensity volume among Mexican Americans and non‐Hispanic Whites: The HABLE study
Authors: King Kevin S. , Vintimilla Raul M , Braskie Meredith N , Wei Ke , Hall James R , Borzage Matt , Johnson Leigh A , Yaffe Kristine , Toga Arthur W , O'Bryant Sid E ,   for the HABLE Study Team
Published: February 2022

AbstractIntroductionAmong vascular risk factors we hypothesized that an increased prevalence of diabetes in Hispanics would be associated with greater white matter hyperintensity (WMH) volume, which may contribute to cognitive decline.MethodsA total of 1318 participants (60% female; 49% Hispanic, 51% non‐Hispanic White; age 66.2 ± 8.9 years) underwent clinical evaluation and brain magnetic resonance imaging (MRI). WMH volume associations were assessed with age, sex, and ethnicity and then with vascular risk factors in a selective regression model.ResultsWMH volume was greater with older age (P < .0001), Hispanic ethnicity (P = .02), and female sex (P = .049). WMH volume was best predicted by age, diastolic blood pressure, hypertension history, hemoglobin A1c (HbA1c), white blood cell count, and hematocrit (P < .01 for all). Elevated HbA1c was associated with greater WMH volume among Hispanics (parameter estimate 0.08 ± 0.02, P < .0001) but not non‐Hispanic Whites (parameter estimate 0.02 ± 0.04, P = .5).DiscussionWMH volume was greater in Hispanics, which may be partly explained by increased WMH volume related to elevated HbA1c among Hispanics but not non‐Hispanic Whites.
Population attributable fraction of modifiable risk factors for dementia in Chile
Authors: Vergara Rodrigo C. , Zitko Pedro , Slachevsky Andrea , San Martin Consuelo , Delgado Carolina 
Published: February 2022

AbstractIntroductionProjected dementia incidence in Latin America and the Caribbean for the next decades is overwhelming. Access to local data, stratified by sex, is imperative for planning precise dementia‐prevention strategies.MethodsWe analyzed the individual and overall weighted population attributable fraction (PAF) of nine modifiable risk factors for dementia, in dementia‐free subjects ≥45‐years‐old, using the 2016‐2017 Chilean National Health Survey.ResultsThe overall weighted PAF for modifiable risk factors was 45.8% (42.2% to 49.3%). Variables with the highest PAF were lower education, high blood pressure, hearing loss, and obesity. Women showed a greater overall weighted PAF: 50.7% (45.3% to ‐56.1%), compared to men: 40.2% (35.4% to 45.0%), driven by a higher PAF for physical inactivity and depression in women.DiscussionThe PAF for modifiable risk factors for dementia in Chile is higher than in previous world reports, due to a greater prevalence of cardiovascular risk factors. Women have a higher potential for dementia prevention.HIGHLIGHTS
The proportion of dementia associated to modifiable risk factors in Chile is 45.8%.
The main modifiable risk factors are high blood pressure, obesity, and hearing loss.
Women had a greater prevalence of physical inactivity and depression than men.
Chile had a greater prevalence of metabolic risk factors than other world regions.
Long‐term monitoring of IOX4 in horse hair and its longitudinal distribution with segmental analysis using liquid chromatography/electrospray ionization Q Exactive high‐resolution mass spectrometry for the purpose of doping control
Authors: Ishii Hideaki , Shibuya Mariko , So Yat‐Ming , Wong Jenny K. Y. , Ho Emmie N. M. , Kusano Kanichi , Sone Yu , Kamiya Takahiro , Wakuno Ai , Ito Hideki , Miyata Kenji , Yamada Masayuki , Leung Gary Ngai‐Wa 
Published: February 2022

AbstractIOX4, a hypoxia‐inducible factor stabilizer, is classified as a banned substance for horses in both horse racing and equestrian sports. We recently reported the pharmacokinetic profiles of IOX4 in horse plasma and urine and also identified potential monitoring targets for the doping control purpose. In this study, a long‐term longitudinal analysis of IOX4 in horse hair after a nasoesophageal administration of IOX4 (500 mg/day for 3 days) to three thoroughbred mares is presented for the first time for controlling the abuse/misuse of IOX4. Six bunches of mane hair were collected at 0 (pre), 1, 2, 3, and 6 month(s) postadministration. Our results showed that the presence of IOX4 was identified in all postadministration horse hair samples, but no metabolite could be detected. The detection window for IOX4 could achieve up to 6‐month postadministration (last sampling point) by monitoring IOX4 in hair. In order to evaluate the longitudinal distribution of IOX4 over 6 months, a validated quantification method of IOX4 in hair was developed for the analysis of the postadministration samples. Segmental analysis of 2‐cm cut hair across the entire length of postadministration hair showed that IOX4 could be quantified up to the level of 1.84 pg/mg. In addition, it was found that the movement of the incorporated IOX4 band in the hair shaft over 6 months varied among the three horses due to individual variation and a significant diffusion of IOX4 band up to 10 cm width was also observed in the 6‐month postadministration hair samples.
Hyper‐palatable food consumption during binge‐eating episodes: A comparison of intake during binge eating and restricting
Authors: Bjorlie Kayla , Forbush Kelsie T. , Chapa Danielle A.N. , Richson Brianne N. , Johnson Sarah N. , Fazzino Tera L. 
Published: February 2022

AbstractObjectiveThe study aim was to elucidate the degree to which hyper‐palatable foods (HPF) are consumed during binge episodes compared to restricting episodes, and to test the association between HPF intake during each episode and respective episode frequency.MethodThis study was a secondary analysis of data from a larger study on eating disorders. The present sample included adults (N = 147, 83% women) diagnosed with sub‐threshold (41%) or full‐threshold (59%) bulimia nervosa (BN). Foods consumed during binge and restricting episodes were assessed using the Eating Pathology Symptoms Inventory–Clinician Rated Version. A standardized definition of HPF developed previously was applied to foods consumed during binge and restricting episodes. A Wilcoxon matched‐pairs signed‐rank test was used to test the difference between total caloric intake from HPF (KcalHPF) and percentage of caloric intake from HPF (PercHPF) during binge episodes relative to restricting episodes. Four linear regression models tested HPF intake (KcalHPF and PercHPF) during both episode types (binge and restricting) as predictors of respective episode frequency.ResultsThere was a significant difference between median KcalHPF (1846.6 vs. 279.6; Z = −13.38, p < .001) and PercHPF during binge compared to restricting episodes (95% vs. 61%; Z = −7.35, p < .001). Regression analyses demonstrated that KcalHPF during binge episodes was significantly associated with binge episode frequency (B = 0.002; p < .001), but not PercHPF (p = .287).DiscussionResults suggest that HPF may be primarily consumed during binge episodes among individuals with BN, and may be associated with greater binge‐eating frequency.Public SignificanceFindings from the current study support an underlying assumption of theoretical models of binge eating, suggesting that highly rewarding, hyper‐palatable foods (HPF), may constitute the vast majority of energy intake during binge‐eating episodes. Additionally, a substantial amount of energy intake from HPF may occur during restricting episodes among people with bulimia nervosa. Greater HPF intake during binge eating may also be associated with binge‐eating severity.
Single arterial access for Ecpella and jugular venous cannulation provides full mobility on a status 1 heart transplant recipient
Authors: Bitargil Macit , Pham Si , Haddad Osama , Sareyyupoglu Basar 
Published: February 2022

AbstractConcomitant treatment with veno‐arterial extracorporeal membrane oxygenation (VA‐ECMO) and Impella may improve outcomes in patients with cardiogenic shock compared with VA‐ECMO alone. Here, we explain a new method to introduce Impella and ECMO through the same arterial access site and jugular venous cannulation to accomplish a mobile patient concept.
Synthesis and Properties of Thieno[3,2‐f]isoquinolines and Benzothieno[3,2‐f]isoquinolines
Authors: Blanco Ponce Marian , Mangione Maria Ines , Hermosilla Espinosa Robinson , Torres Rodríguez Eugenio , Ehlers Peter , Langer Peter 
Published: February 2022

AbstractA variety of thieno[3,2‐f]isoquinolines were prepared by combination of Pd catalysed cross‐coupling reactions with Brønsted acid mediated cycloisomerisations. The reactions tolerate various functional groups and proceed with high selectivity. In addition, benzothieno[3,2‐f]isoquinolines were prepared which represent a new heterocyclic core structure. The optical properties of selected compounds were studied by experimental and theoretical methods. Emission solvatochromism, characteristic of intramolecular charge transfer was observed for one of the compounds with a push‐pull structure.
Ubiquinone electrochemistry in analysis and sensing
Authors: Ó Conghaile Peter , Arrigan Damien W. M. 
Published: February 2022

AbstractUbiquinone (UQ) is a lipophilic compound present in most living organisms, where UQ's interesting but complex electrochemistry serves an important role in the transfer of electrons and protons within and across the mitochondrial membrane. We briefly review the electrochemical characteristics of UQ and its reduced state, ubiquinol, in solution and immobilized on electrodes, together with its application in electrochemical sensing and detection systems, for example, measuring redox status with reference to reactive oxidative species. The importance of the local environment, solvent, electrolyte, organic membrane, and pH, on the electrochemical behavior of UQ, is also discussed. We discuss techniques used for the direct detection of UQ such as liquid chromatography‐electrochemistry. Mediated electrochemistry of UQ allows for quantitative measurements of ions, small molecules, and other analytes such as glucose via chemical sensors and biosensors.
Development of Environmental Decision Support System for Sustainable Smart Cities in India
Authors: Shruti Shruti , Singh Prabhat K. , Ohri Anurag , Singh Ravi S. 
Published: February 2022

AbstractIn the era of advanced technologies, information and communication technology (ICT) is the crucial component for developing Smart Cities. The topical studies indicate that ICT is primarily ignored to improve environmental sustainability in Smart Cities. The present research is an initial effort to develop a web‐based Environmental Decision Support System (EDSS) for Sustainable Smart Cities in India (SSCI). The application developed evaluates a city's performance on a set of 24 environmental indicators, which is broadly categorized into four domains: Solid Waste Management (SWM), Water Supply Management (WSM), Sewerage, Sanitation, and Stormwater Management (SSS), and Ambient Environment Condition (AEC). EDSS‐SSCI can serve as a valuable tool for policymakers in benchmarking a city's existing environmental scenario and grade it on a scale range of critically low, poor, fair, good, and excellent. The developed tool gives information about the city's performance in each domain along with three priority indicators which are decided on the basis of critical performance and higher weights given through the Delphi technique. This study presents the application to a real case study in Varanasi city, which identifies that its environmental sustainability smartness score exists in poor range and the focused attention for improvement is AEC domain. The study outcomes of the application developed will be beneficial for policymakers to define and drive the planning action towards developing Environmentally Sustainable Smart Cities in India.
Thermal and physical characterization of glass fiber phenolic for aircraft interiors
Authors: Najmi Hussain , Luche Jocelyn , Rogaume Thomas 
Published: February 2022

SummaryNowadays, composite materials are used very frequently in the aerospace application due to their superior mechanical properties. Materials used in commercial aircrafts are subject to the stringent flammability regulations set by Federal Aviation Administration. In this context, the peak heat release rate (PHRR) is one of the most important criteria. In the present work, fire behavior of glass phenolic composite is assessed at micro (Thermo‐Gravimetric Analysis [TGA]) and small scale (ISO 5660 cone calorimeter). TGA tests are performed under air and inert atmospheres and cone calorimeter tests are performed at three different heat fluxes (25, 35, and 50 kW m−2) using two different kinds of sample holders: a normal (i.e. ISO‐5660 standard) sample holder and an insulated one. The results show that PHRR obtained in case of an insulated sample holder is higher than the study case with the normal sample holder. Another important result confirms that if the surface temperature reaches its threshold limit, the total mass lost percentage for glass fiber phenolic composite in the cone and TGA is similar. In addition to the cone study, permeability analysis is also performed on the same materials which are exposed to different heat fluxes. The results from permeability study confirm that the permeability of the material increases as they are subjected to the thermal attack.
Modeling for extraction of oil from walnut and sesame using batch flow cold press oil extraction system
Authors: Ghiasi Pedram , Sohrabi Omid , Rahmati Edris , Najafi Gholamhassan , Mohamed Mazlan , Ghasemnezhad Azim 
Published: February 2022

AbstractIn this study, a batch flow oil extraction system was used for extraction of oil from walnut (Juglans regia L.) and Sesamum (Indicum sesame). Sample mass (g), applied pressure (MPa), and processing temperature of oil (°C) were selected as independent variables and oil extraction mass percentage and oil analysis as dependent variables. Response surface methodology was employed for conducting statistical analysis, modeling, and data optimization. The results revealed that the highest percentage of oil extraction for walnut was obtained at a pressure of 10.5 MPa, a temperature of 31.5°C, and a sample weight of 8 g, with a value of 25.36%. Also, the highest percentage of oil extraction for Sesamum was obtained at the pressure of 13.88 MPa, the temperature of 31.5°C, and a sample value of 20 g with a value of 22.4%. Optimal level of independent variables for walnut and sesame were 8.03 g, 10.41 MPa, and 27.37°C; 20 g, 13.88 MPa, and 27°C, respectively. In this optimum condition, the amount of sesame and walnut peroxide was 10 ± 0.03 and 1.9 ± 0.07 (meq O2/kg), respectively. Likewise, the amount of acid for sesame and walnut was 1.53 ± 0.05 and 0.06 ± 0.02 g/%, separately. Linoleic acid (42.7–51.15), oleic acid (38.6–24.03), palmitic acid (10.87–8.21), and stearic acid (5.5–3.39) were the most common fatty acid components in sesame and walnuts, respectively.
Wasl is crucial to maintain microglial core activities during glioblastoma initiation stages
Authors: Mazzolini Julie , Le Clerc Sigrid , Morisse Gregoire , Coulonges Cédric , Zagury Jean‐François , Sieger Dirk 
Published: February 2022

AbstractMicroglia actively promotes the growth of high‐grade gliomas. Within the glioma microenvironment an amoeboid microglial morphology has been observed, however the underlying causes and the related impact on microglia functions and their tumor promoting activities is unclear. Using the advantages of the larval zebrafish model, we identified the underlying mechanism and show that microglial morphology and functions are already impaired during glioma initiation stages. The presence of pre‐neoplastic HRasV12 expressing cells induces an amoeboid morphology of microglia, increases microglial numbers and decreases their motility and phagocytic activity. RNA sequencing analysis revealed lower expression levels of the actin nucleation promoting factor wasla in microglia. Importantly, a microglia specific rescue of wasla expression restores microglial morphology and functions. This results in increased phagocytosis of pre‐neoplastic cells and slows down tumor progression. In conclusion, we identified a mechanism that de‐activates core microglial functions within the emerging glioma microenvironment. Restoration of this mechanism might provide a way to impair glioma growth.
Value of six comorbidity scales for predicting survival of patients with primary surgery for oral squamous cell carcinoma
Authors: Peeters Frederik , Van Dessel Jeroen , Croonenborghs Tomas‐Marijn , Smeets Maximiliaan , Sun Yi , Willaert Robin , Politis Constantinus , Bila Michel 
Published: February 2022

AbstractBackgroundComorbidities influence treatment outcome of oral squamous cell carcinoma (OSCC). This study compared the predictive performance of six comorbidity scales for overall survival after surgery for OSCC.MethodsWe retrospectively analyzed OSCC patients, surgically treated at an academic center in Belgium between January 01, 2000 and January 01, 2020. Validity of the scales was evaluated using the area under the curve (AUC) of receiver operating characteristic curves.ResultsThree hundred and twenty three patients were included. Elixhauser Comorbidity Index (AUC = 0.74, 95% CI: 0.55–0.92; AUC = 0.73, 95% CI: 0.55–0.80), modified Elixhauser Comorbidity Index (AUC = 0.72, 95% CI: 0.54–0.91; AUC = 0.69, 95% CI: 0.51–0.77), and Combined Comorbidity Index (AUC = 0.76, 95% CI: 0.58–0.84; AUC = 0.76, 95% CI: 0.59–0.84) were meaningful predictors for 2 and 5‐year survival, respectively.ConclusionSelected comorbidity scales were capable of predicting overall survival for OSCC patients 2 and 5 years after primary surgery.
Biomechanical investigation of load differences on the upper extremities in dynamic hand strikes and isometric hand pushes during assembly tasks
Authors: Hausmanninger Lukas , Komnik Igor , Fleiter Mario , Potthast Wolfgang 
Published: February 2022

AbstractThis study determines the effects of increasing forces on different musculoskeletal load parameters, such as muscle activity and joint movement, during assembly task‐related dynamic hand strikes and isometric push forces. Fifteen subjects (12 men and 3 women) were instructed to strike and push on a force plate in two selected conditions. In the first condition, the palmar surface of the dominant hand is oriented horizontal to the measuring surface; in the second condition, the body position is maintained, but the hand is turned 90° to allow the use of the ulnar side of the hand (fist strike position). The subjects accomplished four force levels in ascending order (i.e., 150, 250, 350, and 400 N) within the corresponding striking and pushing conditions. The extracted kinematic variables of interest were strike velocity, recoil velocity, force plate contact time, peak vertical reaction force component (force plate), force impulse, muscle activity, and maximum joint ranges of motion during the push or strike process. Differences in the results between pushes and strikes and, under certain circumstances, between fist and palm strikes were identified. Increasing push forces correlate with the muscle activity in the pectoralis and lower arm extensor muscles. The fact that, at push forces > 250 N, the subjects modify and adapt their upper body and arm posture to achieve the required force could reveal an obvious feasibility limit and explain why assembly workers tend to use their hands as a hammer.