bluuebunny/crossref_metadata_2025_split huggingface dataset:
HRCT chest in patients suffering from COVID-19: Experience from a tertiary care centre in India during second wave of the pandemic
Authors: Firdose Syed Ruzina , Mattoo Priyanka , Malik Aadil Hussain , Viqar Arif 
Published: May 2022

Abstract

Aim
The objective of the present study is to describe high-resolution CT (HRCT) chest manifestations of coronavirus disease 2019 (COVID-19) patients during second wave of the pandemic in a tertiary care hospital in New Delhi, India. We also aim to compare the findings on the HRCT chest during the second wave of COVID-19 with the data form earlier outbreaks and to look for any features specific to the second wave and thus indirectly to the delta variant of SARS-CoV-2. We also assessed the severity of the pulmonary involvement based on HRCT findings.

Methods
We analysed HRCT chest findings in 237 patients with COVID-19 admitted at our institute from 1st April 2021 to 31st May 2021. Covid-19 infection was confirmed by reverse transcription polymerase chain reaction (rt-PCR) or rapid antigen test (RAT) in all these patients.

Results
The mean age in our study group was 51.3 ± 12.1 years (range 19–79 years) comprising of 136 males (57.4%) and 101 females (42.6%). The majority of the patients showed bilateral (95.3%) and peripheral (42.6%) distribution of the disease. Ground glass opacities were the most common finding, seen in 214 (90.3%) patients, followed by interlobular septal thickening in 202 (85.8%) and crazy paving in 194 (81.3%) patients. Majority (36.7%) of these patients had a CT severity score above 20 indicating severe disease.

Conclusion
A typical pattern of peripheral subpleural often bilateral distribution of ground glass opacities on HRCT chest usually points to the possibility of COVID-19 pneumonia. The higher incidence of abnormalities on HRCT chest in patients with infection mainly from the delta variant of SARS-Cov-2 was mainly because of the more severe disease in the population. More research is needed to further evaluate the role of HRCT chest in the diagnosis of COVID-19 caused by different strains of the virus.
Long-term outcome of omalizumab-assisted desensitisation to cow’s milk and eggs in patients refractory to conventional oral immunotherapy: real-life study
Authors: Ayats-Vidal Roser , Riera-Rubió Silvia , Valdesoiro-Navarrete Laura , García-González Miguel , Larramona-Carrera Helena , Asensio-De la Cruz Oscar , Bosque-García Montserrat 
Published: May 2022

Background: Oral immunotherapy (OIT) is a promising approach to cow’s milk and egg allergies, but reactions are frequent and some patients cannot be desensitized.
Objective: To evaluate long-term OIT outcomes with omalizumab (OMZ) in paediatric patients with severe egg and/or milk allergies.
Methods: This retrospective real-life study analysed findings in children with Immunoglobulin E-mediated allergy to cow’s milk and/or hen eggs refractory to conventional OIT, who underwent OIT with OMZ in our department between 1 January 2010 and 31 December 2015.
Results: In all, 41 patients were included (median age: 7 years; interquartile range [IQR]: 5.5–9.5); 26/41 (63.4%) underwent OIT for milk, 8/41 (19.5%) for egg and 7/41 (17.1%) for both. The median time between initiation of OMZ and OIT was 27 weeks (IQR: 22–33). Forty (97.56%) patients reached the maintenance phase (200 mL of cow’s milk and 30 mL of raw egg or 1 cooked egg) in a median time of 27 weeks (IQR: 18–37). The median total time with OMZ was 117 weeks (IQR: 88–144). During the OMZ period, 2.44% (1/41) of patients presented anaphylaxis. After discontinuation of OMZ, 29.3% (12/41) presented anaphylaxis, 50% of them had a poor adherence to daily ingestion. One patient (2.44%) was diagnosed with eosinophilic esophagitis after 2 years of discontinuation of OMZ. Currently, after a median time of 9 years (IQR: 7–10) since the initiation of OMZ, 75.6% (31/41) are desensitized (27/31 without OMZ).
Conclusions: Omalizumab allows desensitisation of children with severe allergies to cow’s milk and/or egg without developing severe reactions while receiving this treatment. However, discontinuation of OMZ leads to severe allergic reactions, and hence must be monitored carefully.
Therapeutic effects of acupuncture in rheumatoid arthritis are associated with centromere protein F expression
Authors: Dong Weitao , Wang Bin , Zhang Rongchao , Cao Junyi , Wu Rong 
Published: May 2022

Rheumatoid arthritis is a globally common autoimmune inflammatory disease found especially in China. Acupuncture (AP), a traditional Chinese medicine (TCM) treatment method, is commonly used for treating rheumatoid arthritis. Many studies have demonstrated that acupuncture alone or in combination with other treatments is beneficial to treat clinical situation of rheumatoid arthritis, thus improving function and quality of life. In this study, we found that centromere protein F (CENPF) is a key gene in rheumatoid arthritis with acupuncture treatment by using differentially expressed genes (DEGs) and random forest model analysis of GSE57983 and GSE77298. Acupuncture helps to up-regulate the expression of CENPF in tissues in rheumatoid arthritis. Functionally, overexpression of CENPF inhibits monocyte chemoattractant protein (MCP)-1, tumor necrosis factor (TNF)-α, and Interleukin (IL)-6 expressions whereas deficiency of CENPF facilitates MCP-1, TNF-α, and IL-6 expressions in a collagen-induced arthritis (CIA) rat model. Furthermore, knocked down CENPF with acupuncture treatment antagonizes the inhibition of MCP-1, TNF-α, and IL-6 expressions in a CIA rat model. CENPF could be a crucial biomarker in regulating function of acupuncture in treating rheumatoid arthritis.
Objective: The objective of this study is to study the critical role of CENPF in regulation of rheumatoid arthritis with acupuncture treatment.
Methods: PCA was used to analyze the different expression genes between AP treatment group and control group. Volcano plot and random forest model were used to analyze the decreased and increased expression genes. RT-qPCR and IF were used to measure the expression of CENPF in CIA model rat with or without AP treatment. The expression of MCP-1, TNF-α and IL-6 was measured by western blotting. The pathology character and arthritis index were used to analyze the severity of joint injury.
Results: PCA data showed that the expression of genes was different between AP treatment group and control group from GEO datasets. Volcano plot and random forest model analysis indicated that CENPF is the most significantly increased expression gene after AP treatment. RT-qPCR and IF assay showed that CENPF is reduced expression in CIA model rat, while CENPF is upregulated expression in CIA model rat with AP treatment. Furthermore, overexpression of CENPF reduced the increasing of MCP-1, TNF-α and IL-6 in CIA model rat. On the contrary, CENPF deficiency induced the expression of MCP-1, TNF-α and IL-6 in CIA model rat. Additionally, the expression of MCP-1, TNF-α and IL-6 in CIA model rat was suppressed, whereas knockdown of CENPF antagonized the decrease of MCP-1, TNF-α and IL-6 in CIA model rat with AP treatment.
Conclusions: CENPF may be a key gene in regulation of the therapeutic effects of acupuncture in rheumatoid arthritis.
Recurrent respiratory papillomatosis with lung involvement and malignant transformation
Authors: Ryabova M. A. , Molodtsova V. P. , Portnov G. V. , Akopov A. L. 
Published: May 2022

Recurrent respiratory papillomatosis (RP) is one of the most challenging benign tumors of the upper and lower respiratory tract. Dissemination of the tumor process and damage to the lung tissue not only increase the likelihood of malignancy, but also complicate the choice of treatment tactics, largely limit the surgical options, and necessitate a multidisciplinary approach.Methods. The enrolled patients with RP have been treated (n = 190) in the Federal State Budgetary Educational Institution of Higher Education “Academician I.P.Pavlov First St. Petersburg State Medical University”, Ministry of Healthcare of Russian Federation, from 2000 to the present. Changes in the lung tissue were detected in 5 (2.6%) patients (2 men and 3 women) with aggressive course of the disease.Results. The clinical characteristics of patients and the outcomes of lung damage in RP are presented. Four patients had malignant transformation of the tumor into verrucous carcinoma of the upper third of the trachea with invasion into the soft tissues of the neck (n = 1) or malignant degeneration of the lesion in the lung parenchyma (n = 3).Conclusion. The presented rare observations suggest polymorphism of clinical and radiological symptoms of papillomatous damage to the tracheobronchial system and lungs.
Approaches to vaccination against the new coronavirus infection in solid organ recipients
Authors: Polishchuk V. B. , Kostinov M. P. , Ryzhov A. A. , Karchevskaya N. A. , Тarabrin E. A. , Kallagov T. E. 
Published: May 2022

Solid organ recipients represent a high risk group for all adverse outcomes associated with SARS-CoV-2 infection due to the immunosuppressive treatment and the presence of comorbidities such as cardiovascular disease, diabetes mellitus, and arterial hypertension.The aim of the study was to assess the ability of solid organ recipients to form immune response after vaccination against a new coronavirus infection and safety of the vaccines in this population.Conclusion. An analysis of the literature and the results obtained in Russia show that vaccines against SARS-CoV-2 do not cause unusual clinical events in recipients of solid organs. Levels of post-vaccination antibodies in these patients, especially in the elderly patients shortly after transplantation who take antimetabolites, are lower than in the general population. This group of patients needs alternative immunization schemes against the new coronavirus infection, which may include more than two booster doses or a combination of different types of vaccines, as well as doubling the vaccine dose.
O objeto do museu como documento
Authors: Silva Andre Fabricio , Porpora Bruno Couto 
Published: May 2022

O objeto do museu é o objeto do patrimônio que, pelo seu material e pela sua forma, documenta a realidade na qual foi criado, na qual viveu e com a qual entrou no presente. As propriedades do objeto constituem as características do valor documental. As qualidades mais importantes são: o material, a história, o ambiente e a importância do objeto. O objeto é a fonte e o transmissor da informação. A ideia de objeto de museu reflete suas identidades fundamentais: as identidades conceituais, reais e atuais e aquelas que apresentam sua sequência vertical no tempo e no espaço: uma estrutural, outra funcional. Uma vez que os objetos existem em um contexto, eles também são os documentos de um contexto primário, arqueológico e museológico. O contexto primário é o mais frequente. É neste contexto que os objetos assumem suas propriedades de documento. No contexto arqueológico há uma tensão entre o tempo histórico e o tempo cronológico, portanto, residem as propriedades documentais, enquanto no contexto museológico o objeto expressa e comunica seus valores documentais e protege suas identidades adquiridas. Mudanças no contexto ocorrem regularmente em uma direção e se movem em direção ao contexto museológico. Um objeto no contexto museológico torna-se a testemunha e o testemunho do contexto primário e arqueológico, bem como a fonte de informação para documentação e pesquisa. O objeto museológico é o documento da realidade vivida (Resumo original).
Por uma Campina Grande moderna. Arquitetura e documentação.
Authors: Albuquerque e Melo Alcilia Afonso de , Pereira Ivanilson , Jales Lucas 
Published: May 2022

O artigo pretende divulgar os resultados de estudos que vêm sendo desenvolvidos pelo Grupo de pesquisa arquitetura e lugar/ GRUPAL.UFCG em prol do resgate documental da arquitetura produzida na cidade de Campina Grande, Paraíba, nordeste brasileiro- durante o recorte da modernidade, abarcando o período dos anos 50 a 80 do século XX. Justifica-se trazer à tona tais resultados, por ser uma forma de contribuir com a preservação patrimonial arquitetônica local, regional e nacional- em um cenário dominado por uma crise patrimonial brasileira, que apresenta um quadro difícil, com a falta de uma política preservacionista em todos os seus níveis, e que deveria incentivar as pesquisas, a capacitação técnica, a preservação arquitetônica em todo seu arcabouço documental e da própria obra em si. Documentar, sem dúvida, é o primeiro passo do trabalho de preservação patrimonial. Reunir as informações através de levantamentos arquitetônicos, de ferramentas como o redesenho, a reconstrução virtual, permite com que estas edificações sejam resgatadas, analisadas, documentadas, demonstrando seus atributos arquitetônicos, seus valores projetuais, construtivos, espaciais e socioculturais. Desde maio de 2015, o grupo vem atuando, levantando informações referentes à produção arquitetônica moderna campinense. Ao longo desses anos, foram mais de quinze pesquisas arquitetônicas, que resultaram em inventários, fichamentos, análises, além de artigos publicados em eventos científicos e periódicos, na realização de monografias de trabalhos de conclusão de curso, em projetos de dissertações de mestrado. Resgatar o acervo moderno campinense, sensibilizando a sociedade sobre a importância de preservá- lo é nossa meta, inserindo-o no rol dos bens imóveis de valor cultural para a cidade e seus cidadãos.
Community Risk Mitigation Research
Authors: Ciminski Ryan 
Published: May 2022

One who considers the steps needed in preparing the United States population for disasters asserts a hefty task. While the impacts of disasters and emergencies are on an incline in the United States, a significant percentage of Americans are not prepared for said events. This negatively impacts the safety of our communities and puts homeland security at risk. While children and youth are most impacted by emergencies and disasters, they can be seen as major assets for creating lasting cultural change.
The Chicago School Preparedness study utilized email-administered computer survey via Google Forms to collect data in order to answer questions, how schools are currently preparing students for disaster and how the Federal Emergency Management Agency's (FEMA) free resources for schools, such as the Student Tools for Emergency Planning, are reaching schools. The study also analyzes if affluency factors predict whether or not schools are preparing their students for disaster.
Overall, the results suggest that the educators believe that preparedness is at least somewhat important aspect of curriculum. However, they are not aware of the existence of free preparedness materials, which indicates that income levels might impact school preparedness.
Investigating Algorithmic Decision-Making with Applications to Student Diversity at Illinois Tech
Authors: Khan Alisha 
Published: May 2022

This study focuses on algorithmic decision-making and how structural inequalities can introduce inadvertent bias in an algorithm. There are a lot of efforts by universities in the United States to diversify the student body. Most of these efforts focus on outreach, but few focus on improving any internal processes first.
This study aimed to look for room for improvement to make internal processes more equitable so the rest of the efforts to diversify a student body would be more effective. Specifically, Illinois Tech admissions data was observed and patterns found were tested for statistical significance.
Historia y presente del yeísmo (rehilado) en el Uruguay
Authors: Canale Germán , Coll Magdalena 
Published: May 2022

El yeísmo, así como su rehilamiento y ensordecimiento, son rasgos caracterizadores del español del Uruguay. Varios estudios locales han indagado sobre estos fenómenos atendiendo tanto a cuestiones diacrónicas como sincrónicas. Sin embargo, y tal como se desprende de la literatura especializada, no contamos hasta el momento con una mirada crítica y global de estos estudios ni con una evaluación panorámica de sus resultados. En el presente trabajo, ofrecemos una revisión crítica de las investigaciones sobre el yeísmo, el rehilamiento y el ensordecimiento en el Uruguay, prestando especial atención a la caracterización histórica de estos fenómenos, su estado actual en el sistema fonológico del español del Uruguay y las actitudes asociadas a ellos. Esto nos permite, por un lado, aportar a la caracterización de la historia del español del Uruguay, así como también contribuir con una mirada local a un fenómeno ciertamente complejo en la historia del español. Por otro lado, la revisión crítica de los estudios nos permite identificar sus aportes globales y sus limitaciones específicas e identificar nuevas áreas de investigación en la temática para una caracterización más contundente y acabada de estos fenómenos.
Los notarios Pedro Quispe y Pedro de la Carrera: variación lingüística en el Cuzco del siglo XVI
Authors: Navarro Gala Rosario 
Published: May 2022

En el Cuzco de la última veintena del siglo XVI ejercían su labor de escribanos públicos de cabildo Pedro Quispe y Pedro de la Carrera. El primero de ellos, de origen indígena, dejó un libro de protocolo en que trataba los asuntos particulares de los indígenas que habitaban la parroquia de Nuestra Señora de la Purificación del Cuzco. Pedro de la Carrera realizará la misma labor en el cabildo del Cuzco llevando, sobre todo, los asuntos privados de los habitantes españoles, criollos y mestizos cuzqueños. Los documentos que un día configuraron sus respectivos libros de protocolo sirven de corpus para el presente trabajo. Partiendo de dicha documentación se realiza una aproximación al panorama de variación lingüística en la ciudad de Cuzco en la última veintena del siglo XVI. Variación lingüística que hallamos en el español empleado por indígenas con diferente formación y contrastamos con el castellano de españoles, criollos y, tal vez, algún mestizo de la misma época y ciudad. El corpus documental empleado es original y autógrafo, y está constituido por documentos pertenecientes a una misma tradición discursiva, factores estos que, debidamente aprovechados, contribuyen a la fidelidad de la muestra.
Estructura sintáctica de las construcciones con verbos parasintéticos de los tipos a-…-ar y en-…-ar
Authors: Martínez Vera Gabriel 
Published: May 2022

Postulamos una estructura sintáctica unitaria para las construcciones con verbos parasintéticos de los tipos a-…-ar y en-…-ar mediante cuatro hipótesis: ambos esquemas verbales tienen una estructura sintáctica básica común en relación con Sv y SV, cuyos núcleos son CAUSE y BECOME, respectivamente; la diferencia entre ambos radica en que, dentro de la escala de afectación (Beavers 2011), en relación con a-…-ar, se especifica (composicionalmente) el estado resultante del tema, mientras que, en relación con en-…-ar, ello no tiene lugar. Proponemos que la afectación es un operador ubicado en una proyección externa a Sv, el cual cuantiza el evento determinando la especificidad del estado resultante para el objeto;y la forma morfológica del operador es a- o en- en caso de que su valor seapositivo o negativo respectivamente.
Seguimiento de referencia en náhuatl
Authors: Peregrina LLanes Manuel , Estrada Fernández Zarina 
Published: May 2022

El seguimiento referencial es abordado desde un enfoque funcional-cognitivo y desde una perspectiva tipológica dando cuenta de los mecanismos que esta lengua usa para codificar la referencia y mantener la cohesión a lo largo del texto. Este es un estudio sobre el discurso náhuatl. El análisis está basado en la Estructura de la Información (EI) y la Coherencia Discursiva que se ha documentado por medio del fenómeno lingüístico conocido como seguimiento de la referencia.
El Diccionario de la lengua española (2014): análisis del nuevo discurso lexicográfico de la RAE
Authors: Rodríguez Barcia Susana 
Published: May 2022

Este artículo tiene como principal objetivo dar a conocer algunas actualizaciones en el discurso lexicográfico académico que se evidencian en la vigesimotercera edición del Diccionario de la lengua española en su versión impresa. A través de un análisis contrastivo de las modalidades discursivas presentes en la edición impresa de 2001, las enmiendas en línea para la edición impresa de 2014 (en caso de artículos para los que se propusieran enmiendas como paso previo a la nueva redacción) y las definiciones definitivas ecogidas en la última edición del DRAE establecemos algunas líneas generales de actuación de la Academia en cuanto a la presencia de la voz de las personas responsables de la redacción de los artículos lexicográficos que se vehicula a través de la modalización discursiva.
Literatura, historia y mito de una ciudad: el Cuzco como prólogo (Paisajes peruanos, I)
Authors: Wiesse Rebagliati Jorge 
Published: May 2022

El artículo destaca la relevancia de considerar al primer capítulo de Paisajes peruanos, texto seminal del polígrafo peruano José de la Riva-Agüero y Osma, como el prólogo de todo el libro, pues en la disposición de este —y no solo en su contenido— pueden encontrarse sus grandes temas: la reunión de la naturaleza y la historia del Perú, de lo indígena y lo español. Riva-Agüero contrasta dos perspectivas del Cuzco y descubre en la contemplación del paisaje la esencia de la nación peruana. Al hacerlo, no solo se convierte en el historiador que él mismo añoraba en La Historia en el Perú, sino que genera —mediante procedimientos literarios, imaginativos, connotativos— un mito patrio.
Implementasi Keterampilan Massage Kepada Masyarakat di Kota Banjarbaru
Authors: Rachman Aryadi , Athar Athar 
Published: May 2022

Massage merupakan suatu ilmu alami masyarakat yang berkembang dengan pesat, massage sebagai salah satu kelompok pengobatan tradisional. Massage menjadi salah satu alternatif pengobatan yang diandalkan dalam pengobatan beberapa gangguan kesehatan manusia. Mitra dalam pengabdian ini adalah Aqilla’s Massage Therapy, beberapa terapisnya memiliki kekurangan kualitas pemahaman dan kemampuan massage yang ilmiah, hal ini menjadi masalah tersendiri di Aqilla’s Massage Therapy. Kegiatan pengabdian masyarakat ini bertujuan meningkatkan kualitas terapis dengan memberikan metode dan teknik keterampilan massage, baik teori dan praktik, sehingga terapis Aqilla’s Massage Therapy dapat mengimplementasikannya di lapangan. Metode yang digunakan dalam pelaksanaan pengabdian ini yaitu metode ceramah, diskusi dan praktik. Kegiatan ini melibatkan mitra penyedia jasa terapi pijat kebugaran yaitu Aqilla’s Massage Therapy yang berjumlah 9 orang terapis. Hasil pengabdian masyarakat ini adalah menghasilkan terapis berkualitas yang dapat memberikan layanan kepada masyarakat di Kota Banjarbaru, pada tahun 2021 terdapat peningkatan permintaan layanan jasa di Aqilla’s Massage Therapy sebanyak 69%. Massage is a natural science of society that is growing rapidly, massage as a group of traditional medicine. Massage is one of the reliable alternative treatments in the treatment of several human health disorders. The partner in this service is Aqilla's Massage Therapy, some of the therapists have a lack of quality understanding and scientific massage skills, this is a problem in itself at Aqilla's Massage Therapy. This community service activity aims to improve the quality of therapists by providing methods and techniques of massage skills, both theory and practice, so that Aqilla's Massage Therapy therapists can implement them in the field. The method used in the implementation of this service is the lecture, discussion and practice method. This activity involves partners who provide fitness massage therapy services, namely Aqilla's Massage Therapy, which consists of 9 therapists. The result of this community service is to produce quality therapists who can provide services to the community in Banjarbaru, in 2021 there will be an increase in demand for services at Aqilla's Massage Therapy as much as 69%.