bluuebunny/crossref_metadata_2025_split huggingface dataset:
Anal and oral detection ofTreponema pallidumin men who have sex with men with early syphilis infection
Authors: Towns Janet M , Chow Eric P F , Wigan Rebecca , Fairley Christopher K , Williamson Deborah , Azzato Francesca , Graves Stephen , Zhang Lei , Chen Marcus Y 
Published: October 2022

ObjectivesWe aimed to characterise patterns of anal and oral detection ofTreponema pallidumamong men who have sex with men (MSM) with early syphilis.Methods200 MSM with serologically confirmed primary, secondary and early latent syphilis were tested withT. pallidum polAPCR using an anal canal swab, oral rinse, plus swabs from any anal and oral lesions in a prospective, cross-sectional study. Anal and oralT. pallidumcycle threshold values were compared between subsets of men and according to rapid plasma reagin (RPR) titre.ResultsOf 200 men with early syphilis, 45 and 48 had anal and oralT. pallidumdetected, respectively. Cycle threshold values were lower with anal compared with oralT. pallidumwhether lesions were present or not. Among 27 and 42 men with anal and oralT. pallidumdetected, respectively, and no anal or oral primary lesion, frequency of detection increased with increasing RPR titre, with 95% (25/27) and 98% (41/42) of shedding from respective sites occurring with RPR titres ≥1:16. 6.5% (13/200) of men with syphilis had concurrent detection ofT. pallidumfrom both anal and oral sites: 9/13 with secondary syphilis, 7/9 of whom had anal lesions with a median duration of 30 days (range 7–180 days).ConclusionsThese data suggestT. pallidumload at the anus is higher than at the oral cavity and that a subset of men with secondary syphilis and prolonged anal lesions may be relatively infectious. Earlier detection and treatment of syphilis, when RPR titres are lower than 1:16, could potentially reduce infectiousness from anal and oral sites.
Clinical and radiographic predictors of the need for facial CT in pediatric blunt trauma: a multi-institutional study
Authors: Nguyen Brittany N , Edwards Mary J , Srivatsa Shachi , Wakeman Derek , Calderon Thais , Lamoshi Abdularouf , Wallenstein Kim , Fabiano Tiffany , Cantor Brittany , Bass Kathryn , Narayan Ananth , Zohn Ralph , Chess Mitchell , Thomas Richard D 
Published: October 2022

BackgroundFacial injuries are common in children with blunt trauma. Most are soft tissue lacerations and dental injuries readily apparent on clinical examination. Fractures requiring operative intervention are rare. Guidelines for utilization of maxillofacial CT in children are lacking. We hypothesized that head CT is a useful screening tool to identify children requiring dedicated facial CT.MethodsWe conducted a multicenter retrospective review of children aged 18 years and under with blunt facial injury who underwent both CT of the face and head from 2014 through 2018 at five pediatric trauma centers. Penetrating injuries and animal bites were excluded. Imaging and physical examination findings as well as interventions for facial fracture were reviewed. Clinically significant fractures were those requiring an intervention during hospital stay or within 30 days of injury.Results322 children with facial fractures were identified. Head CT was able to identify a facial fracture in 89% (287 of 322) of children with facial fractures seen on dedicated facial CT. Minimally displaced nasal fractures, mandibular fractures, and dental injuries were the most common facial fractures not identified on head CT. Only 2% of the cohort (7 of 322) had facial injuries missed on head CT and required an intervention. All seven had mandibular or alveolar plate injuries with findings on physical examination suggestive of injury.DiscussionIn pediatric blunt trauma, head CT is an excellent screening tool for facial fracture. In the absence of clinical evidence of a mandibular or dental injury, a normal head CT will usually exclude a clinically significant facial fracture.Level of evidenceIII.
SIRT6 Mitigates Heart Failure With Preserved Ejection Fraction in Diabetes
Authors: Wu Xiaoqian , Liu Huan , Brooks Alan , Xu Suowen , Luo Jinque , Steiner Rebbeca , Mickelsen Deanne M. , Moravec Christine S. , Alexis Jeffrey D. , Small Eric M. , Jin Zheng Gen 
Published: October 2022

Background:
Heart failure with preserved ejection fraction (HFpEF) is a growing health problem without effective therapies. Epidemiological studies indicate that diabetes is a strong risk factor for HFpEF, and about 45% of patients with HFpEF are suffering from diabetes, yet the underlying mechanisms remain elusive.

Methods:
Using a combination of echocardiography, hemodynamics, RNA-sequencing, molecular biology, in vitro and in vivo approaches, we investigated the roles of SIRT6 (sirtuin 6) in regulation of endothelial fatty acid (FA) transport and HFpEF in diabetes.

Results:

We first observed that endothelial SIRT6 expression was markedly diminished in cardiac tissues from heart failure patients with diabetes. We then established an experimental mouse model of HFpEF in diabetes induced by a combination of the long-term high-fat diet feeding and a low-dose streptozocin challenge. We also generated a unique humanized SIRT6 transgenic mouse model, in which a single copy of human SIRT6 transgene was engineered at mouse
Rosa26
locus and conditionally induced with the Cre-loxP technology. We found that genetically restoring endothelial SIRT6 expression in the diabetic mice ameliorated diastolic dysfunction concurrently with decreased cardiac lipid accumulation. SIRT6 gain- or loss-of-function studies showed that SIRT6 downregulated endothelial FA uptake. Mechanistically, SIRT6 suppressed endothelial expression of
PPARγ
through SIRT6-dependent deacetylation of histone H3 lysine 9 around
PPARγ
promoter region; and
PPARγ
reduction mediated SIRT6-dependent inhibition of endothelial FA uptake. Importantly, oral administration of small molecule SIRT6 activator MDL-800 to diabetic mice mitigated cardiac lipid accumulation and diastolic dysfunction.

Conclusions:
The impairment of endothelial SIRT6 expression links diabetes to HFpEF through the alteration of FA transport across the endothelial barrier. Genetic and pharmacological strategies that restored endothelial SIRT6 function in mice with diabetes alleviated experimental HFpEF by limiting FA uptake and improving cardiac metabolism, thus warranting further clinical evaluation.
Contemporary Socioeconomic and Childhood Opportunity Disparities in Congenital Heart Surgery
Authors: Sengupta Aditya , Gauvreau Kimberlee , Bucholz Emily M. , Newburger Jane W. , del Nido Pedro J. , Nathan Meena 
Published: October 2022

Background:
While singular measures of socioeconomic status have been associated with outcomes after surgery for congenital heart disease, the multifaceted pathways through which a child’s environment impacts similar outcomes remain incompletely characterized. We sought to evaluate the association between childhood opportunity level and adverse outcomes after congenital heart surgery.

Methods:
Data from patients undergoing congenital cardiac surgery from January 2011 to January 2020 at a quaternary referral center were retrospectively reviewed. Outcomes of interest included predischarge (early) mortality or transplant, postoperative hospital length-of-stay, inpatient cost of hospitalization, postdischarge (late) mortality or transplant, and late unplanned reintervention. The primary predictor was a US census tract–based, nationally-normed composite metric of contemporary child neighborhood opportunity comprising 29 indicators across 3 domains (education, health and environment, and socioeconomic), categorized as very low, low, moderate, high, and very high. Associations between childhood opportunity level and outcomes were evaluated using logistic regression (early mortality), generalized linear (length-of-stay and cost), Cox proportional hazards (late mortality), or competing risk (late reintervention) models, adjusting for baseline patient-related factors, case complexity, and residual lesion severity.

Results:

Of 6133 patients meeting entry criteria, the median age was 2.0 years (interquartile range, 3.6 months–8.3 years). There were 124 (2.0%) early deaths or transplants, the median postoperative length-of-stay was 7 days (interquartile range, 5–13 days), and the median inpatient cost was $76 000 (interquartile range, $50 000–130 000). No significant association between childhood opportunity level and early mortality or transplant was observed (
P
=0.21). On multivariable analysis, children with very low and low opportunity had significantly longer length-of-stay and incurred higher costs compared with those with very high opportunity (all
P
<0.05). Of 6009 transplant-free survivors of hospital discharge, there were 175 (2.9%) late deaths or transplants, and 1008 (16.8%) reinterventions at up to 10.5 years of follow-up. Patients with very low opportunity had a significantly greater adjusted risk of late death or transplant (hazard ratio, 1.7 [95% CI, 1.1–2.6];
P
=0.030) and reintervention (subdistribution hazard ratio, 1.9 [95% CI, 1.5–2.3];
P
<0.001), versus those with very high opportunity.

Conclusions:
Childhood opportunity level is independently associated with adverse outcomes after congenital heart surgery. Children from resource-limited settings thus constitute an especially high-risk cohort that warrants closer surveillance and tailored interventions.
Can the presence of an author photograph and biography have an impact on article citations? The case of chemistry and chemical engineering
Authors: Dehdarirad Tahereh 
Published: October 2022

Abstract
The aim of this study was to investigate whether the presence of an author photograph and biography in scientific articles could have an impact on article citations. The impact of a photograph and biography, in combination with certain author characteristics (i.e., gender, affiliation country (measured as whether the author was affiliated with a high-income country or not), and scientific impact (measured as whether the author was a high-impact author or not)), was also examined, while controlling for several covariates. This study focused on a sample of articles published in the time span of 2016–2018 in chemistry and chemical engineering journals by Elsevier. The articles were downloaded from Scopus. The analysis was done using random effects within-between model analyses. Within authors, the results showed no significant impact of author photograph and biography on citations. Different patterns were found for visibility of articles when the presence of an author photograph and biography was combined with author characteristics. While being affiliated to a high-income country and being a high-impact author had a positive impact on citations, gender (female) had a negative impact. For gender, there was a small citation disadvantage of 5% for female authors when they provided a photograph and biography.
Deep Time and Environmental Ethics
Authors: Attfield Robin 
Published: October 2022

Abstract
This paper employs the concept of deep time to supply a philosophical argument about the kind of environmental ethics required in the present. Considerations from the evolutionary past are deployed to support the intrinsic value of health and well-being in addition to that of pleasure. The well-being of a species is held to consist in that of its individual members, past, present and future. Duties to species accordingly include promoting the well-being of future species members, since the impacts of human actions in a technological age are spread out across the future. These impacts include impacts on non-human species after humanity has become extinct; if these impacts matter, then a non-anthropocentric ethic is needed to explain why they do, since an anthropocentric ethics is incapable of explaining this.
Belly up or belly down: Effect of body position on snout vent length and total length measurements in American crocodiles (Crocodylus acutus)
Authors: Balaguera-Reina Sergio A. , Mazzotti Frank J. 
Published: October 2022

Abstract
The interpretation of morphometric data is relevant to understanding biological phenomena. Currently, little is known about the effect of body position on morphometric measurements in crocodylians as well as the extent to which these data are interchangeable. We investigated the effect of body position on snout-vent-length (SVL) and total-length (TL) measured ventrally (belly up) and dorsally (belly down) on 725 Crocodylus acutus (mean TL ventral and dorsal 68.49 cm and 69.82 cm, range = 33.1-185.4 cm and 33.8-185.4 cm) across South Florida, United States. We found evidence that body posture significantly influences SVL and TL measurements. However, regardless of body position, the variation found in SVL was less than 1 mm, and for TL was on average only 3 mm. We concluded that even though there is a difference when measuring American crocodiles belly up and belly down, there is a minimal effect on the outcome (less than half centimeter), which falls within the normal measurement instrument error (i.e., measurement tape) even more so under field conditions. If researchers concur that this is an acceptable error, then SVL and TL measurements taken belly up or belly down can be used interchangeably.
Politics of Spiritual Warfare
Authors: Hasu Päivi 
Published: October 2022

Abstract
This article examines the transformation of Pastor Josephat Gwajima of the Glory of Christ Tanzania Church in Dar es Salaam into a Pentecostal Big Man characterized by neopatrimonialism and clientelism. It argues that Pastor Gwajima’s status rests first, on religious mediation and individual as well as collective deliverance, and second, on the long-term creation of a Christian electorate. The paper focuses on Gwajima’s political activism during election campaigns that culminated in the 2020 elections when he became a member of parliament. The article concludes that Gwajima has built his religiopolitical profile on popular discourses of suspicion, witchcraft, and conspiracies, and that his Pentecostal politics expand the field of political power beyond political institutions to include demonic entities. Gwajima spiritually mediates people’s failed efforts to participate in the world of development while acknowledging the national and global inequalities, power asymmetries, and associated moral problems resulting from material and power accumulation.
[RETRACTED] Inscribing Agency in Religious Change
Authors: Shiyuka Karani 
Published: October 2022

Abstract
In the wake of the cultural turn, there has been a gradual shift in the theorization of African religions, from the static structural-functionalist oriented models, towards the insertion of agency. This new approach foregrounds the intentional actions of individuals, or collective actors, to create meaning when confronted with external cultural ideas. The African, therefore, is treated as an active agent capable of manipulating and inventing new religious possibilities, rather than being a puppet of a rigid social structure. This paper is cast in this mould. It examines the agentic role played by the Pokot as they navigated the cultural challenges presented to them by western Christianity during the British colonial rule in Kenya. However, because the agentic power to authorize meaning is never uniformly distributed in any society, this article highlights the central role played by Lukas Pkech in mediating the cultural conflict between the indigenous Pokot religion and western Christianity.
Attentional Moral Perception
Authors: Vance Jonna , Werner Preston J. 
Published: October 2022

Abstract
Moral perceptualism is the view that perceptual experience is attuned to pick up on moral features in our environment, just as it is attuned to pick up on mundane features of an environment like textures, shapes, colors, pitches, and timbres. One important family of views that incorporate moral perception are those of virtue theorists and sensibility theorists. On these views, one central ability of the virtuous agent is her sensitivity to morally relevant features of situations, where this sensitivity is often spoken of in perceptual terms. However, sensibility theorists have often not been careful to specify how to understand their claims about moral sensibilities as perceptual. In this paper, we distinguish between what we call Attentional Moral Perception and Contentful Moral Perception. We argue that sensibility theorists should endorse Attentional Moral Perception, because it has very powerful empirical evidence in its favor, and it can play all of the explanatory roles that the sensibility theorist needs in her theory of moral sensibilities.
Palestinian Dependence on External Health Services: De-development as a Tool of Dispossession
Authors: Asi Yara M. 
Published: October 2022

Abstract
Through multiple mechanisms, armed conflict degrades and destroys health systems, leaving significant gaps in care delivery that lead to worse health outcomes. Civilian populations are often left at the mercy of multiple stakeholders to attain health care. Often, they are unable to meet their needs within their own territory. This has been documented as the case throughout the occupied Palestinian territories for decades. In this paper, I argue that the destruction and de-development of the Palestinian health system is not just a side effect of conflict, but is part of a broader effort of dispossession, disconnecting Palestinians from their land and from each other. I focus on the multiple ways Palestinians are forced to depend on external actors to seek needed care due to the limitations of blockade and occupation, the drivers of these pathways, and the outcomes of this dependence. Lastly, I provide recommendations for refocusing health efforts internally.
Support for Violent Versus Non-Violent Strategies in the Palestinian Territories
Authors: El Kurd Dana 
Published: October 2022

Abstract
What determines support for violent versus nonviolent strategies? I argue that strategy preference is motivated by an individuals’ assessment of their society’s cohesion. Perception of strong social cohesion, as existing literature argues, should increase individual support for nonviolence, as it gives people confidence that their society will be able to carry out that strategy effectively. I build on this work to show that perception of social cohesion does not always reflect individual conditions; in situations where social cohesion is weak, violence becomes attractive specifically to those who recognize this reality. The paper tests these arguments in the case of Palestine, using survey data and experimental methods, specifically polling data from the Arab Opinion Index in the West Bank and Gaza. The evidence shows that individuals who perceive society to be more cohesive prefer violence less. However, respondents may perceive social cohesion as weak, even while they personally enjoy strong social ties and greater social embeddedness. In this scenario, they are more likely to prefer armed resistance because they use their social ties to gain information and assess risk more effectively. Individuals who are networked in political power structures, members of political parties and those with higher levels of education, are those that both enjoy greater social ties and prefer violence to nonviolence. Their social situation helps them to recognize the weakness of social cohesion in society at large and, based on this perception, make certain choices. This suggests that violence in the Palestinian territories is not a spontaneous eruption, but rather a strategic choice that individuals endorse on the basis of a reasoned assessment of available options and constraints.
Comparer la logique et le droit? Quelques remarques théoriques sur l’usage du numérique en droit
Authors: Lassègue Jean 
Published: October 2022

Résumé
La numérisation actuelle du droit permet de revenir sur les liens historiques entre le droit et la logique moderne. En se fondant sur la différence établie par J. Van Heijenoort entre logique «comme calcul» et logique «comme langage», l’article établit des analogies entre différentes interprétations de la logique et différents types de systèmes ou d’instances juridiques : «Common law», systèmes «civils», «cour de cassation», cette dernière notion caractérisant le formalisme hilbertien. Ce formalisme a tenté de réduire la logique «comme langage» à la logique «comme calcul» mais la découverte des limitations internes des formalismes y a mis un terme : d’où le parallèle entre l’échec du programme hilbertien et les difficultés rencontrées dans la numérisation actuelle du droit. Le droit n’est pas réductible à un calcul formel sur des marques écrites : il reste une discipline dans laquelle la parole et le dialogue sont indispensables pour réaliser les buts qu’il s’assigne.
A Paradox About Our Epistemic Self-Conception: Are You an Über Epistemic Superior?
Authors: Walker Mark 
Published: October 2022

Abstract
I hope to show that each of 1, 2, and 3 are plausible, yet we can derive 4:

1.
It is epistemically permissible to believe that our preferred views in multi-proposition disputes are true, or at least more likely true than not.

2.
If it is epistemically permissible to believe that our preferred views in multi-proposition disputes are true, or at least more likely true than not, then it is epistemically permissible for us to believe that we are über epistemic superiors to our disagreeing colleagues in multi-proposition disputes.

3.
It is not epistemically permissible to believe that we are über epistemic superiors to our disagreeing colleagues in multi-proposition disputes.

4.
At least one of 1, 2, or 3, is false.
Building Burhanpur: The Process of Constructing a Mughal City
Authors: Hirsch Rachel 
Published: October 2022

Abstract
When Emperor Akbar (r. 1556–1605) conquered Burhanpur, the capital of the Khandesh sultanate, in 1601, he catalyzed a decades-long process of transforming the city into a regional capital of the Mughal empire. In this essay, I argue that Mughal Burhanpur was constructed in three stages of spatial and architectural developments over the course of three decades. In the first stage, Akbar symbolically appropriated Burhanpur’s preexisting monumental architecture to demonstrate his conquest over the city. In the second stage, subimperial officers expanded the city through prolific patronage of civic architecture, most notably an underground canal system that carried fresh water several kilometers into the city. Lastly, when Shah Jahan (r. 1628–58) moved to the city in 1629, he implemented a new program of architectural construction that transformed Burhanpur from a provincial capital into an imperial one in just over two years. From symbolic appropriation to urban expansion and then to the implementation of an imperial architectural program, this three-part construction process ultimately transformed a town on the edge of an empire into a legible Mughal city.