bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficacy of a Novel Injection Lipolysis to Induce Targeted Adipocyte Apoptosis: A Randomized, Phase IIa Study of CBL-514 Injection on Abdominal Subcutaneous Fat Reduction
Authors: Goodman Greg J , Ho Wilson W S , Chang Kao-Jung , Ling Yu-Fang , Sheu An-Yi 
Published: June 2022

Abstract

Background
CBL-514 is a novel injectable drug that may be safe and efficacious for localized abdominal subcutaneous fat reduction.

Objectives
The aim of this study was to assess the safety and efficacy of CBL-514 in reducing abdominal subcutaneous fat volume and thickness.

Methods
This Phase IIa, open-label, random allocation study consisted of a 6-week treatment period and follow-up at 4 and 8 weeks following the last treatment. Participants were randomly allocated to receive 1.2 mg/cm2 (180 mg), 1.6 mg/cm2 (240 mg), or 2.0 mg/cm2 (300 mg) of CBL-514 with up to 4 treatments, each comprising 60 injections into the abdominal adipose layer. Changes in abdominal subcutaneous fat were assessed by ultrasound at follow-up visits. Treatment-emergent adverse events were recorded.

Results
Higher doses of CBL-514 (unit dose, 2.0 and 1.6 mg/cm2) significantly improved the absolute and percentage reduction in abdominal fat volume (P &lt; 0.00001) and thickness (P &lt; 0.0001) compared with baseline. Although the COVID-19 pandemic halted some participant recruitment and follow-ups, analysis was unaffected, even after sample size limitations.

Conclusions
CBL-514 injection at multiple doses up to 300 mg with a unit dose of 2.0 mg/cm2 is safe, well-tolerated, and reduced abdominal fat volume and thickness by inducing adipocyte apoptosis. Although other procedures exist to treat abdominal fat, they have limitations and may cause complications. At a dose of 2.0 mg/cm2, CBL-514 safely and significantly reduced abdominal fat volume by 24.96%, making it a promising new treatment for routine, nonsurgical abdominal fat reduction in dermatologic clinics.

Level of Evidence: 4
A Social Work Model of Historical Trauma
Authors: Rosenwald Mitchell , Baird Jennifer , Williams Jennifer 
Published: June 2022

Abstract
This article introduces a Social Work Model of Historical Trauma. The model draws from social work perspectives (ecosystems theory and the life model, human rights philosophy, race-based traumatic stress injury theory and attachment theory), disparities research, social work issues and policy statements, social work ethics and epigenetics. Assessment and intervention in micro, mezzo and macro domains are discussed. The article concludes with a case vignette and model application.
Plasma thioredoxin reductase: a potential diagnostic biomarker for gastric cancer
Authors: Zhu Yinxing , Hu Yixuan , Zhu Xuedan , Zhang Juan , Yuwen Daolu , Wei Xiaowei , Tang Cuiju , Zhang Wenwen 
Published: June 2022

Abstract
To improve the early detection of gastric cancer (GC), there is a growing need for novel and efficient biomarkers. We aimed to evaluate diagnostic value of thioredoxin reductase 1 (TXNRD1), which was found to be over expressed in various malignancies. We found that TXNRD1 has a higher expression level in GC tissues compared with adjacent normal tissues, and high TXNRD1 expression was significantly associated with poor outcomes of GC patients. Next, a total of 1446 cases were collected, with 896 cases in GC, 322 in benign gastric disease and 228 in healthy controls. We noticed plasma thioredoxin reductase (TrxR) level in GC [8.4 (7.1, 9.7) U/ml] was significantly higher than that in benign disease [6.1 (5.4, 7.2) U/ml] or healthy controls [3.7 (1.7, 5.6) U/ml]. Receiver operating characteristic analysis showed that the optimal cutoff value of TrxR activity for GC diagnosis was set at 5.75 U/ml with an area under the curve of 0.945. Moreover, a combined panel of TrxR and routine tumor markers could further elevate the diagnostic efficacy compared to a single biomarker. Finally, by measuring pre- and post-treatment TrxR activity and routine tumor markers, we found the change trend of them was broadly consistent, and plasma TrxR activity was significantly decreased in patients treated with platinum/fluorouracil-based therapy. Our findings recommend plasma TrxR activity combined with tumor markers as effective diagnostic tools for GC patients. As well, plasma TrxR has the potential to monitor therapeutic efficacy.
Effector-selective modulation of the effective connectivity within frontoparietal circuits during visuomotor tasks
Authors: Bencivenga Federica , Tullo Maria Giulia , Maltempo Teresa , von Gal Alessandro , Serra Chiara , Pitzalis Sabrina , Galati Gaspare 
Published: June 2022

AbstractDespite extensive research, the functional architecture of the subregions of the dorsal posterior parietal cortex (PPC) involved in sensorimotor processing is far from clear. Here, we draw a thorough picture of the large-scale functional organization of the PPC to disentangle the fronto-parietal networks mediating visuomotor functions. To this aim, we reanalyzed available human functional magnetic resonance imaging data collected during the execution of saccades, hand, and foot pointing, and we combined individual surface-based activation, resting-state functional connectivity, and effective connectivity analyses. We described a functional distinction between a more lateral region in the posterior intraparietal sulcus (lpIPS), preferring saccades over pointing and coupled with the frontal eye fields (FEF) at rest, and a more medial portion (mpIPS) intrinsically correlated to the dorsal premotor cortex (PMd). Dynamic causal modeling revealed feedforward-feedback loops linking lpIPS with FEF during saccades and mpIPS with PMd during pointing, with substantial differences between hand and foot. Despite an intrinsic specialization of the action-specific fronto-parietal networks, our study reveals that their functioning is finely regulated according to the effector to be used, being the dynamic interactions within those networks differently modulated when carrying out a similar movement (i.e. pointing) but with distinct effectors (i.e. hand and foot).
Aberrant Mesenteric Adipose Extracellular Matrix Remodelling is Involved in Adipocyte Dysfunction in Crohn’s Disease: The Role of TLR-4-mediated Macrophages
Authors: Zuo Lugen , Li Jing , Zhang Xiaofeng , Geng Zhijun , Song Xue , Wang Yueyue , Ge Sitang , Shi Ruohan , Zhou Yueqing , Ge Yuanyuan , Wu Rong , Hu Jianguo 
Published: June 2022

Abstract

Background and Aims
Hypertrophic mesenteric adipose tissue [htMAT] is involved in the disease progression of Crohn’s disease [CD] through expressing proinflammatory adipokines from dysfunctional adipocytes by unknown mechanism. Adipocyte function is affected by dynamic adipose tissue extracellular matrix [ECM] remodelling that is mainly mediated by macrophages, and our study aimed to reveal whether aberrant ECM remodelling was present in CD-htMAT and its effects on adipocyte dysfunction, as well as the mechanism.

Methods
ECM remodelling was examined in MAT samples from CD patients and controls. Mice with dinitrobenzene sulphonic acid [DNBS]-induced colitis were used in vivo study, and lipopolysaccharide [LPS]-induced remodelling behaviour in macrophages was examined in vitro. Macrophages or TLR4 inhibition were used to analyse ECM remodelling mechanisms and their effects on adipocyte function.

Results
Aberrant ECM remodelling: was observed in CD-htMAT, which was characterised by a widened and deformed ECM structure accompanied by dysregulated matrix synthesis and degradation; served as a reservoir for inflammatory factors/cells dominated by macrophages; and was involved in adipocyte dysfunction. In addition, macrophages were the main source of ECM remodelling regulatory factors with activation of Toll-like receptor 4 [TLR4] in htMAT. In vivo, macrophage depletion or TLR4 inhibition largely attenuated mesenteric ECM remodelling while improving mesenteric adipocyte dysfunction during chronic enteritis. In vitro, antagonizing TLR4 significantly inhibited LPS-induced macrophage ECM remodelling behavior.

Conclusions
The aberrant ECM remodelling in CD-htMAT contributed to mesenteric adipocyte dysfunction, which may be caused at least partly by TLR4-mediated macrophage remodelling behavior. Inhibiting ECM remodelling may be a potential therapeutic strategy for CD.
Functional stress imaging to predict abnormal coronary fractional flow reserve: the PACIFIC 2 study
Authors: Driessen Roel S , van Diemen Pepijn A , Raijmakers Pieter G , Knuuti Juhani , Maaniitty Teemu , Underwood S Richard , Nagel Eike , Robbers Lourens F H J , Demirkiran Ahmet , von Bartheld Martin B , van de Ven Peter M , Hofstra Leonard , Somsen G Aernout , Tulevski Igor I , Boellaard Ronald , van Rossum Albert C , Danad Ibrahim , Knaapen Paul 
Published: June 2022

Abstract

Aims
The diagnostic performance of non-invasive imaging in patients with prior coronary artery disease (CAD) has not been tested in prospective head-to-head comparative studies. The aim of this study was to compare the diagnostic performance of qualitative single-photon emission computed tomography (SPECT), quantitative positron emission tomography (PET), and qualitative magnetic resonance imaging (MRI) in patients with a prior myocardial infarction (MI) or percutaneous coronary intervention (PCI).

Methods and results
In this prospective clinical study, all patients with prior MI and/or PCI and new symptoms of ischaemic CAD underwent 99mTc-tetrofosmin SPECT, [15O]H2O PET, and MRI, followed by invasive coronary angiography with fractional flow reserve (FFR) in all coronary arteries. All modalities were interpreted by core laboratories. Haemodynamically significant CAD was defined by at least one coronary artery with an FFR ≤0.80. Among the 189 enrolled patients, 63% had significant CAD. Sensitivity was 67% (95% confidence interval 58–76%) for SPECT, 81% (72–87%) for PET, and 66% (56–75%) for MRI. Specificity was 61% (48–72%) for SPECT, 65% (53–76%) for PET, and 62% (49–74%) for MRI. Sensitivity of PET was higher than SPECT (P = 0.016) and MRI (P = 0.014), whereas specificity did not differ among the modalities. Diagnostic accuracy for PET (75%, 68–81%) did not statistically differ from SPECT (65%, 58–72%, P = 0.03) and MRI (64%, 57–72%, P = 0.052). Using FFR &lt; 0.75 as a reference, accuracies increased to 69% (SPECT), 79% (PET), and 71% (MRI).

Conclusion
In this prospective head-to-head comparative study, SPECT, PET, and MRI did not show a significantly different accuracy for diagnosing FFR defined significant CAD in patients with prior PCI and/or MI. Overall diagnostic performances, however, were discouraging and the additive value of non-invasive imaging in this high-risk population is questionable.
A recursive matched-filter to systematically explore volcanic long-period earthquake swarms
Authors: Wimez M , Frank W B 
Published: June 2022

SummaryThe matched-filter technique is an effective way to detect repeats, or near-repeats, of a seismic source, but prior identification of an event from that source to use as a template is required. We propose a recursive matched-filter approach to systematically explore earthquake swarms, here applied to a swarm of volcanic long-period seismicity beneath Mount Sidley in Antarctica. We start with a single visually chosen template event with a high signal-to-noise ratio. We then extend our template database by selecting new templates to use in a subsequent matched-filter search from the newly detected set of events, allowing us to recursively expand the number of templates. We demonstrate that each iteration of the matched-filter search progressively extends the spatial coverage of our set of templates away from the original template event. In such a way, our proposed method overcomes the matched-filter search’s strictest constraint: that an event must already be identified to detect other similar events. Our recursive matched-filtering approach is well suited for the systematic exploration of earthquake swarms in both volcanic and tectonic contexts.
An enigma in rock magnetism: can microstructures in magnetite cause a threefold increase in the efficiency of NRM acquisition in the Stardalur Basalts?
Authors: McEnroe Suzanne A , Church Nathan , Fabian Karl , Stange Marianne F , van Helvoort Antonius T J 
Published: June 2022

SUMMARYQuaternary lavas of the Stardalur Caldera, 20 km northeast of Reykjavik, Iceland, create a 27 300 nT magnetic anomaly visible in both ground and aeromagnetic surveys. Here, we provide a comprehensive mineralogical and rock magnetic data set to analyse NRM intensities and Koenigsberger ratios of 57 drill-core samples from the critical zone (CZ) of the anomaly high at depths between 41 and 131 m. This extends previous studies and verifies that the anomaly is due to an unusually high intensity of remanent magnetization carried by magnetite. The NRM of the CZ samples was acquired during the Olduvai subchron in a field of at most today’s strength. NRM intensities range from 20 to 128 A m–1 with a median of 55 A m–1, and an average of 61 A m–1, respectively, approximately 13–15 times higher than in typical Icelandic basalts (AIB) with an NRM intensity of 4 A m–1. Our new data set shows that the magnetite concentration throughout the CZ basalts is at most twofold higher than in AIB lavas. New data on domain state and TRM efficiency prove that these properties account for an additional factor of at most 2.3. Because magnetite is the most abundant remanence carrier in rocks on Earth, and its remanence acquisition is considered to be extremely well understood, we assert that the remaining discrepancy is a critical enigma in rock magnetism. Results from scanning electron microscopy show that a significant fraction of all CZ magnetite particles have dendritic shapes with grain sizes &lt;1 μm, indicating rapid crystallization. Most large magnetite grains are heavily subdivided by very fine oxidation-exsolution lamellae of ilmenite, and subordinate amount of exsolved spinel as needles, blebs and blades. These common microstructures found throughout the CZ subdivide the initially homogeneous mineral into separate cubicles, here denoted as compartments. The magnetite compartments then have sizes below 1 μm. Hysteresis data, Preisach maps and FORC data consistently confirm that the coercivity distribution is dominated by values above 10 mT, such that multidomain behaviour is of little relevance in the CZ. Between 5 and 20 per cent of the IRM is carried by coercivities above 100 mT, which for magnetite indicates unusually high anisotropy effects in the individual particles. Based on the quantitative analysis of all magnetic contributions to the NRM, we can demonstrate that the average efficiency of NRM acquisition in the CZ Stardalur basalts must be at least a factor 3 higher than in typical basalts. We speculate that this is related to the observed focused compartment size distribution &lt;1 μm, and indicates thermochemical remanence acquisition below the Curie temperature of magnetite. Yet, a detailed physical mechanism for the extreme overefficiency of NRM acquisition remains enigmatic.
An efficient method to propagate model uncertainty when inverting seismic data for time domain seismic moment tensors
Authors: Poppeliers Christian , Preston Leiph 
Published: June 2022

SUMMARY
We present a computationally efficient method to approximately propagate uncertainty when linearly inverting seismic data for point source, time variable moment tensor components. The method is based on the assumption that the data residual, given by the difference between the observed seismic data and the data predicated by a linear inversion, contains the effects of both data and model uncertainty. Our method uses a distribution of data residuals, added directly to the data, in a pseudo-Monte Carlo scheme. Using the assumption that the data residual is a stochastic process, we use the well-known Karhunen–Loève (KL) theorem to construct a distribution of data residuals, where the required basis functions are constructed using Fourier series. The Fourier series are scaled by a product of a random variable and the real-valued spectral amplitudes of the original data residual’s spectrum. Thus, the Fourier series and spectral amplitudes are eigenfunction-eigenvalue pairs used in the KL-based construction of data residual distribution. Using tests with synthetic data, we show that our method compares closely with a Finite Difference Monte Carlo (FDMC) method that we presented previously. More importantly, the method presented here is computationally several orders of magnitude faster than our previous FDMC method, and requires no a priori assumptions of model and/or data uncertainty.
Cerebellar contribution to threat probability in a SCA6 mouse model
Authors: Bohne Pauline , Rybarski Max , Mourabit Damian Boden-El , Krause Felix , Mark Melanie D 
Published: June 2022

Abstract
Fear and anxiety have proven to be essential during the evolutionary process. However, the mechanisms involved in recognizing and categorizing threat probability (i.e. low to high) to elicit the appropriate defensive behavior are yet to be determined. In this study, we investigated the cerebellar contribution in evoking appropriate defensive escape behavior using a purely cerebellar, neurodegenerative mouse model for spinocerebellar ataxia type 6 which is caused by an expanded CAG repeat in exon 47 of the P/Q type calcium channel α1A subunit. These mice overexpress the carboxy terminus (CT) of the P/Q type calcium channel containing an expanded 27 CAG repeat specifically in cerebellar Purkinje cells (CT-longQ27PC). We found that our CT-longQ27PC mice exhibit anxiolytic behavior in the open field, elevated plus maze and light/dark place preference tests, which could be recovered with more threatening conditions such as brighter lighting, meowing sounds and an ultrasound repellent. Their innate fear to find safety in the Barnes maze and visual cliff tests was also diminished with subsequent trials, which could be partially recovered with an ultrasound repellent in the Barnes maze. However, under higher threat conditions such as in the light/dark place preference with ultrasound repellent and in the looming tests, CT-longQ27PC mice responded with higher defensive escape behaviors as controls. Moreover, CT-longQ27PC mice displayed increased levels of CT-labeled aggregates compared with controls. Together these data suggest that cerebellar degeneration by overexpression of CT-longQ27PC is sufficient to impair defensive escape responses in those mice.
A natural mutation of the NST1 gene arrests secondary cell wall biosynthesis in the seed coat of a hull-less pumpkin accession
Authors: Lyu Xiaolong , Shi Lu , Zhao Meng , Li Zhangping , Liao Nanqiao , Meng Yiqing , Ma Yuyuan , Zhou Yulan , Xue Qin , Hu Zhongyuan , Yang Jinghua , Zhang Mingfang 
Published: June 2022

Abstract
Hull-less pumpkins (Cucurbita pepo L.) are naturally occurring novel variants known as oilseed or naked-seeded pumpkins, and are characterized by the absence of a normal lignified seed coat. Due to a specialized seed coat structure, these variants serve as a good model for studying seed coat formation and simplify the processing of pumpkin seeds. However, causal genes for this hull-less trait still remain unknown. Here, by bulked segregant analysis and fine mapping, we found that mutation of a single gene, NAC SECONDARY WALL THICKENING PROMOTING FACTOR 1 (NST1), accounts for the hull-less trait. A 14-bp sequence insertion in the CpNST1 gene causes premature termination of CpNST1 translation, leading to lack of secondary cell wall (SCW) biosynthesis in hull-less seed coats. In situ hybridization analysis provided further evidence for the role of CpNST1 in pumpkin seed coat SCW biosynthesis. Interestingly, through secondary cell wall compositional analysis, we found that the main SCW components differed among cell layers in the seed coat. RNA-seq analysis indicated an upstream role of CpNST1 in the SCW biosynthesis network. Collectively, our findings provide mechanistic insight into seed coat SCW biosynthesis, and a target gene for breeders to introduce this hull-less trait for commercial exploitation.
Social Work Leadership Competencies for Practice amid Crisis: A Scoping Review
Authors: Hussain Amina , Ashcroft Rachelle 
Published: June 2022

Abstract
Leadership skills are a critical component of effective social work practice in interdisciplinary healthcare and mental healthcare settings. Over the last two decades there has been increased attention to the importance of social work leadership skills for clinical practice. Moreover, social workers display essential leadership skills when supporting individuals and communities amid large-scale crises such as pandemics, natural disasters, wars, and other sociopolitical crises. Currently, there is an absence of literature on social work leadership skills for effective practice in healthcare and mental healthcare settings during times of crisis. To bridge this knowledge gap, this scoping review aimed to synthesize and map the current literature on social work leadership competencies in healthcare and mental healthcare amid crises. Arksey and O’Malley’s five-stage framework for scoping reviews guided this project. Six academic databases were searched, and a total of nine articles met inclusion criteria. A thematic analysis was conducted to identify recurrent themes among these articles. Results highlight that leadership was defined as both a role and a skill set, and identified collaboration, connection, and shared learning as key leadership competencies for social workers. Implications for social work practice, education, and research are discussed.
Security cooperation in the Pacific Islands: architecture, complex, community, or something else?
Authors: Wallis Joanne , McNeill Henrietta , Batley James , Powles Anna 
Published: June 2022

Abstract
In the 2018 Boe Declaration, Pacific Islands Forum leaders recognized that the region is facing ‘an increasingly complex regional security environment’ and committed to ‘strengthening the existing regional security architecture’. Given uncertainty about the existence and nature of this architecture, we address the question: is there a security architecture in the region, or does security cooperation take a different shape? We find that security cooperation in the Pacific Islands does not constitute a security architecture, as there is no ‘overarching, coherent and comprehensive security structure for a geographically-defined area’. We also find that the region is neither a security complex nor a community, due to the extensive involvement of metropolitan powers and external partners. Instead, we argue that security cooperation in the Pacific Islands is best described as a patchwork of bilateral, minilateral, and multilateral, formal and informal agencies, agreements, and arrangements, across local, national, regional, and international levels