bluuebunny/crossref_metadata_2025_split huggingface dataset:
Palliative radiotherapy of bone metastases in octogenarians: How do the oldest olds respond? Results from a tertiary cancer center with 288 treated patients
Authors: Rühle Alexander , Nya Yompang Verlaine Ange , Spohn Simon K. B. , Stoian Raluca , Zamboglou Constantinos , Gkika Eleni , Grosu Anca-Ligia , Nicolay Nils H. , Sprave Tanja 
Published: September 2022

Abstract
Background
Accompanied by the demographic change, the number of octogenarian cancer patients with bone metastases will increase in the future. Palliative radiotherapy constitutes an effective analgesic treatment; however, as pain perception and bone metabolism change with increasing age, the analgesic efficacy of radiotherapy may be altered in elderly patients. We therefore investigated the treatment outcomes of palliative radiotherapy for bone metastases in octogenarians.

Methods
Patients between 80 and 89 years undergoing radiotherapy for bone metastases between 2009 and 2019 at a tertiary cancer center were analyzed for patterns-of-care, pain response and overall survival (OS). Logistic regression analyses were carried out to examine parameters associated with pain response, and Cox analyses were conducted to reveal prognostic parameters for OS.

Results
A total of 288 patients with 516 irradiated lesions were included in the analysis. The majority (n = 249, 86%) completed all courses of radiotherapy. Radiotherapy led to pain reduction in 176 patients (61%) at the end of treatment. Complete pain relief at the first follow-up was achieved in 84 patients (29%). Bisphosphonate administration was significantly associated with higher rates of pain response at the first follow-up (p < 0.05). Median OS amounted to 9 months, and 1-year, 2-year and 3-year OS were 43%, 28% and 17%. In the multivariate analysis, ECOG (p < 0.001), Mizumoto score (p < 0.01) and Spinal Instability Neoplastic Score (SINS) (p < 0.001) were independent prognosticators for OS.

Conclusion
Palliative radiotherapy for bone metastases constitutes a feasible and effective analgesic treatment in octogenarian patients. ECOG, Mizumoto score and SINS are prognosic variables for survival and may aid treatment decisions regarding radiotherapy fractionation in this patient group. Single-fraction radiotherapy with 8 Gy should be applied for patients with uncomplicated bone metastases and poor prognosis. Prospective trials focusing on quality of life of these very old cancer patients with bone metastases are warranted to reveal the optimal radiotherapeutic management for this vulnerable population.
The technical features of the diagnosis or treatment of coronary artery disease through the distal radial artery approach at the anatomical snuffbox compared with the conventional radial artery approach
Authors: Xu Yingkai , Niu Hongzhen , Yu Yi , Yang Lixia , Wang Haiyang , Zhang Biyang , Zhao Qi , Yong Qiang , Zhou Yujie 
Published: September 2022

Abstract
Background
To compare the surgical effects of coronary intervention through the transradial intervention (TRI) versus distal transradial intervention (dTRI) approach.

Methods
From September 2020 to April 2021, 302 patients undergoing coronary artery angiography (CAG) or percutaneous coronary intervention in our hospital were retrospectively included. Patients were divided into the TRI group and dTRI group with 151 cases in each group. The technique features, lesion features, and cannulation process were compared between the two groups.

Results
The number of patients who underwent CAG in the dTRI group (35.1%) was significantly greater compared with the TRI group (12.6%) (P < 0.01). The rates of triple vessel lesions, calcification lesions and chronic total occlusion lesions were increased in the TRI group compared with the dTRI group (P < 0.05). The average radial artery diameter (RAD) in the TRI group (2.550 ± 0.417 mm) was greater than that in the dTRI group (2.070 ± 0.360 mm) (P < 0.05). The hemostasis time of the dTRI group (173.272 ± 41.807 min) was lower than that of the TRI group (273.417 ± 42.098 min) (P < 0.05). The radial artery occlusion (RAO) rates in the dTRI group (2.6%) were lower than those in the TRI group (8.6%) (P < 0.05). The dTRI group had a higher satisfaction score than the TRI group (P > 0.05). RAD at the puncture site was a predictor of the overall cannulation success rate with an AUC of 0.747 (95% CI 0.663–0.860; P < 0.05).

Conclusions
Despite a steep learning curve, the dTRI approach had a shorter hemostasis time, reduced RAO rates, and notable preliminary safety results compared with the TRI approach. The dTRI approach can be used as a supplemental method to the TRI approach.
Fibrodysplasia ossificans progressiva in Brazil: challenges and strategies to create assistance and educational networks
Authors: Zorzi Alessandro Rozim , Delai Patricia R. , Rosa Henrique L. C. , Brito Wander E. , Montalli Victor A. M. , Napimoga Juliana C. , Napimoga Marcelo H. , Nociti Francisco H. 
Published: September 2022

AbstractFibrodysplasia ossificans progressiva (FOP) is an ultrarare condition and one of the most impactful disorders associated with progressive heterotopic ossification events. It is estimated that there are 120–150 patients in Brazil; however, currently, fewer than 100 patients have been identified, and the role of a FOP advocacy group (FOP Brazil) has been instrumental for the identification and follow-up of these individuals and families. The aim of this article is to summarize the current status of FOP in Brazil and describe strategies proposed to approach this challenge in a continental size country.
Digital psychosocial intervention for depression among older adults in socioeconomically deprived areas in Brazil (PRODIGITAL-D): protocol for an individually randomised controlled trial
Authors: Nakamura Carina Akemi , Scazufca Marcia , Moretti Felipe Azevedo , Didone Thiago Vinicius Nadaleto , de Sá Martins Mariana Mendes , Pereira Luara Aragoni , de Souza Caio Hudson Queiroz , de Oliveira Gabriel Macias , da Costa Marcelo Oliveira , Machado Marcelo , da Silva Bitencourt Evelyn , dos Santos Monica Souza , Murdoch Jamie , van de Ven Pepijn , Seward Nadine , Hollingworth William , Peters Tim J. , Araya Ricardo 
Published: September 2022

Abstract
Background
Depression in older adults is a challenge for health systems in most low- and middle-income countries (LMICs). Digital strategies for the management of this condition have been emerging worldwide, but the effectiveness of most of them is still unclear, especially among older adults. Thus, we aim to assess the effectiveness and cost-effectiveness of a digital psychosocial intervention to treat depression among older adults living in socioeconomically deprived areas in Guarulhos, Brazil.

Methods
We will conduct a two-arm individually randomised controlled trial with 1:1 allocation ratio. Five hundred older adults aged 60 years or over with depressive symptomatology (9-item Patient Health Questionnaire score, PHQ-9 ≥ 10) and registered with one of the primary care clinics will be recruited to participate in this study. A 6-week digital psychosocial programme, named Viva Vida, will be delivered via WhatsApp to participants allocated to the intervention arm. The Viva Vida will send psychoeducational and behavioural activation audio and visual messages 4 days a week for 6 weeks. The control arm will only receive a single message with general information about depression. The primary outcome will be the proportion of depression recovery (PHQ-9 < 10) assessed at 3 months. The cost-effectiveness of the intervention will be assessed at 5 months. A detailed process evaluation will be used to explore context and important implementation outcomes.

Discussion
This programme was based on the PROACTIVE intervention and designed to be delivered without face-to-face contact. If effective, it could be a simple treatment option, appropriate not only when social distancing is required, but it could also be included as a regular public health programme to initiate depression treatment, particularly in LMICs where resources allocated to mental health are scarce.

Trial registration
Registro Brasileiro de Ensaios Clínicos (ReBEC), RBR-4c94dtn. Registered on 22 October 2021 (submitted on 03 August 2021).
Male mating preference in an ixodid tick
Authors: Fracasso Gerardo , Heylen Dieter , Matthysen Erik 
Published: September 2022

Abstract
Background
Mate choice is a fundamental element of sexual selection and has the potential to shape the evolution of traits. Mate choice based on body size has been shown to be a common trait in several arthropod species. In hard ticks, a taxon of medical and veterinary importance, engorgement weight is positively correlated with reproductive output but it is unknown whether adult males show mate choice. Here, we experimentally investigated whether males (i) use chemical cues to choose their mating partner, (ii) consistently choose for the same female individual and (iii) prefer females with highest weight after feeding.

Methods
We used two experimental setups which allowed chemical communication between ticks: (i) a horizontal tube preventing physical contact with the female and (ii) an arena where tactile cues were allowed. In total, we tested 62 different triads in 124 tests (66 tests in the horizontal tube and 58 in the arena) composed of one male that could choose between two engorged females. Specifically, we tested 42 triads in the tube and 46 in the arena; 24 triads were repeatedly tested in the tube while 38 triads were tested in both setups.

Results
We found no preference for individual or heavier females in either setup. However, in the horizontal tube setup, males significantly preferred females that were not visited by them in the previous test.

Conclusions
Our results suggest a lack of male mate choice despite heavier females having higher fecundity. However, future studies should take into account that males may recognize the potential mating partners they previously met.

Graphical Abstract
Efficacy of afoxolaner (NexGard®) against natural infestations with Trichodectes canis in dogs under field conditions
Authors: Mihalca Andrei Daniel , Deak Georgiana , Panait Luciana Cătălina , Rabei Ștefan , Beugnet Frederic 
Published: September 2022

Abstract
Background
Trichodectes canis is a small chewing louse found globally that primarily infests dogs. Limited information is available on the efficacy of isoxazolines against infestation with the chewing louse. In the present study, we evaluated the efficacy of afoxolaner, an isoxazoline class compound, in naturally infested domestic dogs.

Methods
The field study was carried out in Romania. Between September 2021 and December 2021, 43 dogs with confirmed T. canis infestation were included in the study. On the day of the inclusion (day 0), each animal was clinically examined and randomly treated with a control product labeled for use against lice [fipronil-(S)-methoprene combination (Frontline Combo®; Boehringer Ingelheim)] or with the investigational product [chewable tablets containing afoxolaner (NexGard®; isoxazoline)]. Each animal was evaluated for the presence of lice at 15 and 30 days post-inclusion.

Results
Of the 48 dogs initially included in the study, 43 completed the treatment period [18 in the control group (CG) and 25 in the investigational group (IG)]. At day 14, no living T. canis lice were detected on the dogs in either group. At day 14, dead lice were detected in four dogs in the IG, while eggs were present in two dogs in the IG and in one dog in the CG. At day 30, no lice were detected in either group, while eggs were still present in one dog in the CG.

Conclusion
These results suggest that afoxolaner is a feasible treatment option against chewing lice in dogs, providing 100% curative efficacy.

Graphical Abstract
Fibroadenoma in axillary accessory breast tissue: a case report
Authors: Yefter Ermias Teklehaimanot , Shibiru Yitagesu Aberra 
Published: September 2022

AbstractBackgroundAccessory breast(s) is defined as the presence of more than two breasts with or without a nipple and areola in human beings. It may occur anywhere along the primitive embryonic milk lines, which extend from the axilla to the groin. Accessory breast tissue can potentially undergo the same physiological and pathological processes as the normally located breast, including lactational change, fibroadenoma, and carcinoma. Although common in the normally located breast tissue, the incidence of fibroadenoma in accessory breast tissue is rare. Furthermore, if the swelling occurs in the axilla or groin, it may present a diagnostic challenge by clinically mimicking a lymphoma or other causes of lymphadenopathy. Owing to its rarity and its tendency to pose a clinical diagnostic challenge, we decided to report a case of fibroadenoma in axillary accessory breast.Case presentationA 28-year-old Ethiopian female patient came to University of Gondar comprehensive specialized hospital with a complaint of left axillary swelling of 3 years duration. There was no history of cough, fever, weight loss, or night sweating. On physical examination, there was an approximately 5 × 4 cm, firm, well-defined, mobile, nontender solitary mass in the left axilla that was completely separated from the left breast. Fine-needle aspiration cytology suggested a diagnosis of fibroadenoma in axillary accessory breast tissue. The mass was completely excised, and histopathologic examination confirmed the diagnosis. Her recovery was uneventful. She was informed about the diagnosis, reassured, and discharged from care.ConclusionIn the clinical evaluation of a patient with axillary swelling, accessory breast tissue disorders such as fibroadenoma must be considered as a differential diagnosis for early diagnostic workup and management. Moreover, this case underscores the fact that, similar to normal breast tissue, accessory breast tissue is also susceptible to the same pathologic disease processes including neoplasms such as fibroadenoma.
Loneliness in pregnant and postpartum people and parents of children aged 5 years or younger: a scoping review
Authors: Kent-Marvick Jacqueline , Simonsen Sara , Pentecost Ryoko , Taylor Eliza , McFarland Mary M. 
Published: September 2022

AbstractBackgroundDespite evidence that loneliness increases during times of transition, and that the incidence of loneliness is highest in young adults, loneliness during pregnancy and new parenthood has not been developed as a program of research. Because loneliness research has primarily focused on older adults and other high-risk populations, the concept of loneliness and its effects on this population are not well understood, leaving a gap in our understanding of the psychosocial needs and health risks of loneliness on pregnant people and new parents. A scoping review has been completed in order to map and synthesize the literature on loneliness experienced during pregnancy and the first 5 years of parenthood prior to the COVID-19 pandemic.MethodsTo address the aim of this review, a wide net was cast in order to detect experiences of perinatal or parental loneliness and/or instances where loneliness was measured in this population. Among the inclusion criteria were loneliness in people who were pregnant, who were parents in the postpartum period, or who had children aged 5 years or younger. A search for literature was conducted in December 2020 using nine databases: MEDLINE (Ovid), EMBASE (Elsevier), SCOPUS (Elsevier), Cochrane Library including CENTRAL (Wiley), CINAHL (Ebscohost), PsycINFO (Ebscohost), Dissertations & Theses Global (ProQuest) and Sociological Abstracts (ProQuest), and the Web of Science Core Collection (Clarivate).ResultsPerinatal and parental loneliness studies are limited and have rarely been targeted and developed through a program of research. Loneliness inquiry in this population was frequently studied in relation to other concepts of interest (e.g., postpartum depression). Alternatively, the importance of loneliness emerged from study participants as relevant to the research topic during qualitative inquiry. Across studies, the prevalence of loneliness ranged from 32 to 100%. Loneliness was commonly experienced alongside parenting difficulties, with parents feeling as though they were alone in their struggles.ConclusionsAs loneliness has been called a sensitive indicator of mental wellbeing, we believe screening will help healthcare professionals identify common difficulties and early signs of depression experienced during pregnancy and parenthood.Systematic review registrationThe protocol is available on Open Science Framework at DOI 10.17605/OSF.IO/BFVPZ.
A maturity model for AI-empowered cloud-native databases: from the perspective of resource management
Authors: Feng Xiaoyue , Guo Chaopeng , Jiao Tianzhe , Song Jie 
Published: September 2022

AbstractCloud-native database systems have started to gain broad support and popularity due to more and more applications and systems moving to the cloud. Various cloud-native databases have been emerging in recent years, but their developments are still in the primary stage. At this stage, database developers are generally confused about improving the performance of the database by applying AI technologies. The maturity model can help database developers formulate the measures and clarify the improvement path during development. However, the current maturity models are unsuitable for cloud-native databases since their architecture and resource management differ from traditional databases. Hence, we propose a maturity model for AI-empowered cloud-native databases from the perspective of resource management. We employ a systematic literature review and expert interviews to conduct the maturity model. Also, we develop an assessment tool based on the maturity model to help developers assess cloud-native databases. And we provide an assessment case to prove our maturity model. The assessment case results show that the database’s development direction conforms to the maturity model. It proves the effectiveness of the maturity model.
Identification of recurrent variants implicated in disease in bicuspid aortic valve patients through whole-exome sequencing
Authors: Chen Shasha , Jin Qinchun , Hou Shiqiang , Li Mingfei , Zhang Yuan , Guan Lihua , Pan Wenzhi , Ge Junbo , Zhou Daxin 
Published: September 2022

AbstractBicuspid aortic valve (BAV) is the most common congenital heart defect in human beings, with an estimated prevalence in the general population of between 0.5 and 2%. Moreover, BAV is the most common cause of aortic stenosis in the pediatric population. Patients with BAV may have no symptoms for life, and some of them may progress to aortic stenosis. Genetic factors increase the susceptibility and development of BAV. However, the pathogenesis and BAV are still unclear, and more genetic variants are still needed for elucidating the molecular mechanism and stratification of patients. The present study carried out screening of variants implicated in disease in BAV patients. The whole-exome sequencing (WES) was performed in 20 BAV patients and identified 40 different heterozygous missense mutations in 36 genes (MIB2, FAAH, S100A1, RGS16, MAP3K19, NEB, TTN, TNS1, CAND2, CCK, KALRN, ATP10D, SLIT3, ROS1, FABP7, NUP205, IL11RA, NPR2, COL5A1, CUBN, JMJD1C, ANXA7, TRIM8, LGR4, TPCN2, APOA5, GPR84, LRP1, NCOR2, AKAP11, ESRRB, NGB, AKAP13, WWOX, KCNJ12, ARHGEF1). The mutations in these genes were identified as recurrent variants implicated in disease by in silico prediction tool analysis. Nine genes (MIB2, S100A1, TTN, CCK, NUP205, LGR4, NCOR2, ESRRB, and WWOX) among the 36 genes were identified as variants implicated in disease via unanimous agreement of in silico prediction tool analysis and sequenced in an independent cohort of 137 BAV patients to validate the results of WES. BAV patients carrying these variants demonstrated reduced left ventricular ejection fractions (LVEF) (63.8 ± 7.5% vs. 58.4 ± 5.2%, P < 0.001) and larger calcification volume [(1129.3 ± 154) mm3 vs. (1261.8 ± 123) mm3, P < 0.001]. The variants in TTN, NUP205 and NCOR2 genes are significantly associated with reduced LVEF, and the variants in S100A1, LGR4, ESRRB, and WWOX genes are significantly associated with larger calcification volume. We identified a panel of recurrent variants implicated in disease in genes related to the pathogenesis of BAV. Our data speculate that these variants are promising markers for risk stratification of BAV patients with increased susceptibility to aortic stenosis.
Possible modifications of parchment during ion beam analysis
Authors: Csepregi Ákos , Szikszai Zita , Targowski Piotr , Sylwestrzak Marcin , Müller Katharina , Huszánk Róbert , Angyal Anikó , Döncző Boglárka , Kertész Zsófia , Szarka Máté , Reiche Ina 
Published: September 2022

Abstract
Ion beam analysis (IBA) is an established method to determine the concentration and the distribution of elements in art and archaeological objects. However, especially for organic specimens, caution must be taken to avoid harmful effects. In this work, the possible modification of recent calf parchment samples by proton beam irradiation was investigated applying fluences (given as deposited charge per unit area) both within and beyond the usual analytical practice. Attenuated Total Reflection Fourier Transform Infra-red Spectroscopy (FTIR-ATR) and Optical Coherence Tomography (OCT) were employed to assess changes, inspected from the surface of the samples. Although both techniques are apt to detect alterations of parchment in general, in the case of particles, which deposit the majority of their energy below the surface these techniques could not detect changes at low fluences. However, a simple “bath test” (short immersion in liquid) proved that disintegration within the material had already happened. After the “bath test”, OCT and digital 3D microscopy were used to check the discontinuities in the material, especially for low fluences when the visual inspection might have missed them. Unfortunately, simply monitoring organic objects such as parchment during or after ion beam irradiation, non-destructively, is not sufficient to claim absolute harmlessness, as some studies in the past did. In line with our former findings using electron microscopy on cross sections, we found that 2.3 MeV protons with a deposited charge of 0.5 µC/cm2 caused no changes affecting the integrity of parchment but 2 µC/cm2 apparently did under the applied experimental conditions. To ensure the required analytical signal at a relatively low deposited charge, the detection system must be optimized for efficiency. Nevertheless, since the variability of the historic materials and the measurement set-ups are considerable, these values cannot be taken as absolutes, but only as guides, both for further IBA studies and for studies conducted in the past.