bluuebunny/crossref_metadata_2025_split huggingface dataset:
Apprehension of Spurious Information - A Hybrid Architecture to Detect COVID Fake News
Authors: Mahalakshmi G S , Srih S , Shakthiprarthana V , Sendhilkumar S 
Published: July 2022

Abstract
Propagation of false information has an enduring effect on the economy and can lead to political tensions. In order to counterattack this unexpected repercussion, a system has to be modelled to distinguish the hoax from the real. This paper proposes a deep learning based hybrid model that can determine if the news is veracious. The performance of the model is tested on four datasets including COVID fake news to ensure that it is able to generalise across different domains and achieve best results. Bidirectional Gated Recurrent Units emerges to be the ideal decoder to work along with the Convolutional Neural Network in this hybrid architecture while the words being represented using the glove.6B.50D embeddings provided to be the best representation when juxtaposed with Word2Vec, BERT Embeddings, glove.6B.100D and keras embedding layer. Experiments on the datasets show promising results with an overall accuracy of 80.17% on Disaster Tweets, 99% on ISOT dataset, 59.86% on LIAR and 90.05% on COVID Fake News dataset.
Sleep patterns correlates with the efficacy of tDCS on post-stroke patients with chronic disorders of consciousness
Authors: Yu Jie , Wu Yuehao , Wu Biwen , Xu Chuan , Cai Jiaye , Wen Xinrui , Meng Fanxia , Zhang Li , He Fangping , Hong Lirong , Gao Jian , Li Jingqi , Yu Jintai , Luo Benyan 
Published: July 2022

Abstract
Background: The subclassification of chronic disorders of consciousness (DoC) based on sleep patterns is important for the evaluation and treatment of the disease. This study evaluates the correlation between polysomnographic patterns and the efficacy of transcranial direct current stimulation (tDCS) in patients with chronic DoC due to stroke. Methods: In total, 33 patients in the vegetative state (VS) with sleep cycles or without sleep cycles were randomly assigned to either active or sham tDCS groups . Polysomnography was used to monitor sleep changes before and after intervention. Additionally, clinical scale scores and electroencephalogram (EEG) analysis were performed before and after intervention to evaluate the efficacy of tDCS on the patients subclassified according to their sleep patterns. Results: The results suggest that tDCS improved the sleep structure, significantly prolonged total sleep time (TST) (95%CI:14.387-283.527, P =0.032) and NREM sleep stage 2 (95%CI:3.157-246.165, P =0.045) of the VS patients with sleep cycles. It also significantly enhanced brain function of patients with sleep cycles, which were reflected by the increased clinical scores (95%CI: 0.340-3.440, P =0.02), the EEG powers and functional connectivity in the brain and the 6-month prognosis. Moreover, the changes in NREM sleep stage 2 had a significant positive correlation with each index of the β band. Conclusion: This study reveals the importance of sleep patterns in the prognosis and treatment of chronic DoC and provides new evidence for the efficacy of tDCS in post-stroke patients with VS patients subclassified by sleep pattern. Trial registration: URL: https://www.clinicaltrials.gov. Unique identifier: NCT03809936. Registered 18 January 2019.
“This is really something: same place, same day result, same day treatment” Women’s experiences of testing positive for HPV and receiving same-day treatment in Papua New Guinea: an interpretative phenomenological analysis
Authors: Camara Hawa , Nosi Somu , Munnull Gloria , Badman Steven G , Bolgna John , Kuk Joseph , Mola Glen DL , Guy Rebecca , Vallely Andrew J. , Kelly-Hanku Angela 
Published: July 2022

Abstract
Introduction:
Human papillomavirus (HPV) testing is transforming cervical screening globally. The World Health Organization (WHO) now recommends same-day HPV screen-and-treat for primary cervical screening in low- and middle-income countries (LMIC) but there is a lack of evidence on women’s lived experience of testing positive for oncogenic HPV and receiving same-day treatment. This study aimed to address this knowledge gap among women participating in a same-day HPV screen-and-treat (HPV S&T) program in Papua New Guinea.
Methods
As part of a larger qualitative study, this paper explores the lived experiences of 26 women who tested positive for oncogenic HPV and were treated the same day. We analysed the data using the interpretative phenomenological analysis method. All data were managed using Nvivo 12.5.
Results
The interpretative phenomenological analysis led to three superordinate themes: 1) alleviating initial worries, (2) transforming the disclosure process, and (3) connecting to their faith. Women’s experiences of the same day HPV screen-and-treat were framed by initial emotional reactions to their positive HPV test result, and having access to treatment on the same day, which helped address their worries and fears, and transformed their experience of disclosing their test result and subsequent treatment to family and friends.
Conclusion
This study shows that, while women experience similar initial emotional reactions, undergoing same day treatment quickly resolved the women’s worries, making this program highly acceptable. Overall, women’s engagement in the program confirmed its high acceptability and cultural congruence, leaving women feeling empowered and hopeful about their future, and the future of all Papua New Guinea women.
Design and manufacturing of a hip joint motion simulator with a novel modular design approach
Authors: Torabnia Shams , Mihcin Senay , Lazoglu Ismail 
Published: July 2022

Abstract
In vitro motion stimulation of the hip-joint prosthesis helps predict the critical parameters of the products more realistically than in silico investigations. For the joint prosthesis, Wear, the size of debris, fatigue life, and range of motion are some of the essential parameters to investigate. This study designs and develops a hip joint wear simulator using novel approaches. The simulator dynamics were modeled. The forces are calculated from the dynamic loading used for weight optimization, which reduces the forces acting on each joint and improves the quality of the motion transferred to the femoral head. The concept design compared with the topology-optimized shape, gravitational and dynamic forces due to the arm weights.
The prognostic value and immune correlation of IL18 expression and promoter methylation in renal cell carcinoma
Authors: Wang Xiaonan , zhu wancui , Chen Enni , Long Qian , Sun Haohui , Li Xiaodi , Xu Hailin , Li Weizhao , Dong Pei , He Liru , Chen Miao , Deng Wuguo 
Published: July 2022

Abstract
Background: Renal cell carcinoma (RCC) is not sensitive to immunotherapy and have poor prognosis. DNA methylation regulates gene expression, and its abnormal changes are related to many human diseases. Recently, DNA methylation has been found to participate in immune infiltration in various cancers. However, its pattern in RCC remains poorly understood. Results: We found that IL18 was significantly over-expressed in RCC tumor tissues compared to normal adjacent tissues. The IL18 promoter region was hypomethylated, which was strongly correlated with elevated IL18 mRNA expression, and predicted advanced clinicopathological characteristics and shorter overall survival. Furthermore, we found that IL18 promoter methylation was significantly related to the down-regulation of immune checkpoint molecules and increase of CD8+ T cell infiltration in RCC tumor tissues.Conclusions: We have identified the important role of IL18 promoter methylation and expression, which are associated with clinicopathological characteristics, overall survival, immune cell infiltration and expression of immune checkpoint molecules in RCC. We present the rationale for IL18 promoter methylation as a molecular biomarker for predicting the response of RCC to immune checkpoint inhibitors.
Practices, beliefs, and attitudes of clinicians in prescribing direct oral anticoagulants for obese adults with atrial fibrillation
Authors: Shaikh Fahad , Wynne Rochelle , Castelino Ronald L , Inglis Sally C , Davidson Patricia M , Ferguson Caleb 
Published: July 2022

Abstract
Background: Atrial fibrillation (AF) and obesity affect over 60 and 650 million people, respectively. Aim: To explore clinician practices, beliefs, and attitudes towards the use of direct oral anticoagulants (DOACs) in obese individuals with AF.Methods: An exploratory qualitative interview study of clinicians, with expertise in DOAC use in individuals with AF. Data was analysed in NVIVO using thematic analysis.Results: Fifteen clinicians including cardiologists (n=5), hospital pharmacists (n=5), general practitioners (n=2), a haematologist, a neurologist and a clinical pharmacologist participated. Interviews lasted for an average of 31 ± 9 minutes. Key themes revealed were: (1) Health system factors in decision-making: Disparities between rural and metropolitan geographic areas, with regards to access, availability of health services, and time limitations for in-patient decision making, were described. (2) Condition related factors in decision-making: Clinicians questioned the significance of obesity as part of decision-making due to the practical limitations of dose modification, and the rarity of the extreme obese cohort.(3) Decision-making in the context of uncertainty: Clinicians reported limited availability, reliability and awareness of primary evidence including limited guidance from clinical guidelines for DOAC use in obesity. Conclusion: The interplay between obesity and AF, in the context of a challenging healthcare environment, impacts DOAC prescription decision-making. This study highlights limitations in availability, reliability, and awareness of evidence. The intrinsic complexity of the obese cohort coupled with limited guidance from clinical practice guidelines, equates to an urgent need for contemporary research to improve the quality of evidence to guide informed shared decision-making.
Vessel size as a marker of survival in estrogen receptor positive breast cancer
Authors: Milosevic Vladan , Edelmann Reidunn J. , Winge Ingeborg , Strell Carina , Mezheyeuski Artur , Knutsvik Gøril , Askeland Cecilie , Wik Elisabeth , Akslen Lars A. , Östman Arne 
Published: July 2022

Abstract
Background
Angiogenesis is crucial for tumor growth and is one of the hallmarks of cancer. In this study, we analyzed microvessel density, vessel median size, and perivascular a-SMA expression as prognostic biomarkers in breast cancer.
Methods
A set of dual IHC staining was performed where alpha-SMA antibodies were used together with antibodies against the endothelial cell marker CD34. Digital images of stainings were analyzed to extract quantitative data on vessel density, vessel size and perivascular alpha-SMA status.
Results
The analyses in the discovery cohort (n = 108) revealed a statistically significant relationship between large vessel size and shorter disease specific survival (p = 0.007, log-rank-test; p = 0.01, HR 3.1; 95% CI: 1.3–7.4, Cox-regression analyses). Subset analyses indicated that the survival association of vessel size was enriched in ER + breast cancer. To consolidate these findings, additional analyses were performed on the validation cohort (n = 267) where a significant poor prognosis association of large vessel size was also detected in ER + breast cancer (p = 0.016, log-rank-test; p = 0.02; HR 2.3, 95% CI: 1.1–4.7, Cox-regression analyses).
Conclusions
Alpha-SMA/CD34 dual IHC staining revealed breast cancer heterogeneity regarding vessel size, vessel density and perivascular a-SMA status. Large vessel size was linked to shorter survival in ER + breast cancer.
CT scanner quality control using a quality assurance phantom and a PMMA phantom
Authors: Sisay Tadelech 
Published: July 2022

Abstract
Background: The American Association of Physics in Medicine recommends using a specific phantom for quality control and to evaluate the operation of the CT scanner. The current studies' objectives were to determine the multi- slice Philips CT scanner's performance through rigorous quality control testing. Image quality was estimated using a quality assurance CT phantom and radiation dose was assessed using a PMMA head and a PMMA body phantom with a 100mm pencil chamber. The image quality performance parameters that were tested were CT image noise, uniformity, CT number accuracy, and resolution. The radiation dose performance parameters that were evaluated were volume computed tomography dose index (CTDIvol), and dose length product (DLP).Result: The results of the present study were all image quality and CT dose index parameters tested within the acceptable standard limits. The CT radiation dose parameter and image quality test were accepted because they were within the tolerance values. Conclusion: All CT scanners must pass the CT quality control test in order for their performance to be improved.
YTHDF1-TRAF6 pathway regulated neuroinflammation response contributed morphine tolerance and hyperalgesia in periaqueductal gray
Authors: Zhang Jianxing , Ouyang Handong , Chi Dongmei , Zhang Kun , Huang Yongtian , Huang Wan , Bai xiaohui 
Published: July 2022

Abstract
Opioids like morphine have negative side effects such analgesia tolerance and morphine induced hyperalgesia (MIH), which is why their usage is restricted. Raising the dosage of morphine counteracts analgesic tolerance and MIH. Here, we discover that YTHDF1 and TNF receptor-associated factor 6 (TRAF6) expression, which are crucial for morphine analgesic tolerance and MIH. The m6A reader YTHDF1 positively controls the translation of TRAF6 mRNA, and chronic morphine treatments can enhance the m6A modification of TRAF6 mRNA. TRAF6 protein is drastically reduced by YTHDF1 knockdown, although TRAF6 mRNA level is unaffected. By reducing inflammatory markers such TNFα, IL-6, IL-1β and NF-κB, targeted reduction of YTHDF1 or suppression of TRAF6 activity in ventrolateral periaqueductal gray (vlPAG) slows the development of morphine analgesia tolerance and MIH. Our findings provide new insights into the mechanism by which YTHDF1 participates in morphine analgesia tolerance and MIH by regulating the inflammatory response involved in the expression of TRAF6 protein.
Experimental study on ultrasonic assisted electrolyte plasma polishing of SUS304 stainless steel
Authors: Chen Yangjian , Yi Jun , Wang Zongwei , Zhou Wei , Deng Hui 
Published: July 2022

Abstract
A new method of ultrasonic assisted electrolyte plasma polishing (UEPP) is proposed to solve the problem that the oxidation layer generated on the anode workpiece surface in the process of Electrolytic Plasma and Polishing (EPP) cannot be removed completely, which affects the polishing efficiency and surface quality of the workpiece. Firstly, the polishing mechanism of UEPP is described and set up an experimental platform. Taking SUS304 stainless steel as the experimental object, comparative experiments of UEPP and EPP polishing are carried out to verify the beneficial effect of ultrasonic vibration on improving polishing efficiency and polishing quality. The results show that under the same polishing parameters, the introduction of ultrasonic vibration can improve the polishing efficiency by nearly 30%. After UEPP process, the workpiece has better surface texture, the number of surface scratches is greatly reduced, and lower surface roughness can be obtained. In addition, 40KHz is the best ultrasonic vibration parameter. The optimization experiments of UEPP polishing process parameters are further carried out. For SUS304 stainless steel, the optimal polishing process parameters are power supply voltage of 250V, polishing solution concentration of 4%wt, polishing solution temperature of 80℃ under 40KHz ultrasonic assisted conditions. The surface roughness of the experimental workpiece can be reduced from the initial Sa0.5μm to Sa0.02μm after 40 minutes of polishing under the optimized process parameters.
Pedigree reconstruction and population structure using SNP markers in Gir cattle
Authors: Guimaraes Simone , Garcia Arielly , Otto Pamela , Rocha Renata , Santos Mateus , Silva Marcos , Panetto João , Oliveira Daniele , Júnior Luiz Glatz , Machado Marco , Verneque Rui 
Published: July 2022

Abstract
Our objective was to establish a SNPs panel for pedigree reconstruction using chips of different densities and evaluate the genomic relationship coefficient of the inferred pedigree, in addition to analyzing the population structure based on genomic analyses in Gir cattle. For parentage analysis and genomic relationship, 16,205 genotyped Gir animals were used being 14,458 females and 1,747 males, and 1,810 common markers to the four SNP chips. For population structure analyses, which include linkage disequilibrium, effective population size, and runs of homozygosity (ROH), the genotypes of 21,656 animals were imputed. The likelihood ratio (LR) approach was used to reconstruct the pedigree. The LR approach deepened the pedigree and showed that it is well established in terms of recent information for this breed. The coefficients for each relationship category of the inferred pedigree were adequate. Linkage disequilibrium showed rapid decay. We detected a decrease in the effective population size over the last 50 generations, with the average generation interval estimated at 9.08 years. A higher ROH-based inbreeding coefficient in a class of short segments of ROH, with moderate to high values was also detected, suggesting the presence of bottlenecks in the Gir cattle genome. Breeding strategies to minimize inbreeding and avoid massive use of a few proven sires with high genetic value are suggested to maintain genetic variability in future generations. In addition, we recommend reducing the generation interval to maximize genetic progress and increase effective population size.
Prediction of Rotor Slot Size Variations in Induction Motor Using Polynomial Chirplet Transform and Regression Algorithms
Authors: J Anish Kumar , N.R Shanker 
Published: July 2022

Abstract
For constant monitoring of rotor slot in Induction Motor (IM), Average Rotor Slot Variation (ARSV) prediction is proposed. The rotor slots expand due to thermal stress and high intensity magnetic flux. The magnetic flux with high intensity is created in rotor lamination sheet because of Stretching and Curving (SC) magnetic flux. The surface of rotor slot exhibits thermal stress due to over current, which in turn generates heat in rotor transferred to rotor lamination surface. The magnetic stress based rotor slot size variation is never monitored or measured. In the proposed ARSV method, multimodal sensor signals such as Giant magnetoresistance (GMR), Temperature, Current, Vibration and Voltage acquires magnetic stress & temperature stress of rotor. Acquired signals are analyzed through Polynomial Chirplet Transform (PCT) to obtain energy band values of signal.The energy band values and microscopic camera image based rotor slot variation values are used for ARSV prediction.The prediction of ARSV is computed using Polynomial Regression (PR) method.From experimental results, ARSV greater than 5% leads to extreme damage to the motor through vibration, sparking and harmonics. The accuracy of prediction for ARSV is about 94.6% when compared to manual measurement of slots in rotor. Moreover the prediction of ARSV avoids the major faults namely eccentricity, overload, under voltage, unbalance voltage, induced rotor slot and rotor crack rotor burn.
Usefulness of the skeletal muscle index in postoperative ileus of colorectal cancer patients : a case control study
Authors: Sasaki Maho , Fukuoka Tatsunari , Shibutani Masatsune , Sugimoto Atsushi , Maeda Kiyoshi , Ohira Masaichi 
Published: July 2022

Abstract
Background:Postoperative complications of colorectal cancer mainly include infections (surgical site infection, remote infection, etc.), post-operative ileus (POI), and anastomosis leakage. POI reportedly prolongs the hospital stay and increases medical costs. Therefore, predicting POI is very important. There have been some reports on the relationships between sarcopenia and postoperative complications in colorectal cancer patients, but none have been limited to POI. We therefore conducted a retrospective clinical study with a logistic regression analysis to confirm the risk factors for ileus after colorectal cancer surgery.Methods:We retrospectively analyzed 213 patients who underwent radical surgery for colorectal cancer from November 2017 to July 2021. The skeletal muscle mass (SMM, kg) was estimated using a whole-body bioelectrical impedance analysis (BIA), and the skeletal muscle index (SMI) was calculated as the SMM / height2. We divided all patients into 2 groups based on a low SMI (male <8.958 kg/m2, female <8.443 kg/m2) or normal SMI. Preoperative and intraoperative factors as well as, postoperative outcomes were then compared between the two groups.Results:The median (range) age of the 213 included patients was 72.0 (33-91) years old. Complications were noted in 100 patients (46.9 %), including 21 (9.9 %) with POI. There were 68 (31.9 %) low SMI patients. POI occurred significantly more frequently in low SMI patients (19.1 %) than in normal SMI patients (5.5 %) (p = 0.005). In the multivariate analysis, bleeding (p=0.005) and a low SMI (p = 0.044) were significantly associated with POI. In addition, a propensity score matching analysis was performed to further reduce the selection bias. As a result, a low SMI was the only independent POI predictor among the 74 matched cases.Conclusion:A preoperative low SMI in colorectal cancer patients was considered a risk factor for POI.
Silica grafted DBU Supported NiCl2 : A Sustainable heterogeneous catalyst for A3 coupling
Authors: Pharande P. S. , Rashinkar G. S. , Pore D. M. 
Published: July 2022

Abstract
Silica grafted DBU supported NiCl2 complex, SiO2@DBU-NiCl2 has been designed and synthesized by multistep approach and characterized by FT-IR, XRD, EDS, FE-SEM and TGA. Catalytic activity of SiO2@DBU-NiCl2 has been explored for A3 coupling of terminal alkynes, aldehydes and secondary amines. Special features of present protocol are high TONs and TOFs, low catalyst loading (0.08 mol %), solvent-free conditions and reusability of the catalyst.
Experimental investigations into effect of milling parameters on milling force and burr micro morphology for Zr-based bulk metallic glass by using groove milling
Authors: Liu Yin , Gong Yadong , Cui Xiaoqing , Liang Zhengyi , Liu Weijun , Yuan Zewei , Yang Heran , Dong Zhixu , Sun Xingwei 
Published: July 2022

Abstract
Zr-based bulk metallic glass is an amorphous alloy. In order to study the burr problem in the groove milling process of Zr-based bulk metallic glass, the milling force in the process is studied experimentally. Then the effect of milling parameters on the burr of Zr-based bulk metallic glass was studied, and the relationship between milling force and burr was analyzed. In order to further study the milling burr of amorphous alloy, under the same test parameters, the single crystal alloy material (nickel base single crystal superalloy DD5) and the traditional polycrystalline metal material (304 stainless steel) were selected for comparative test and analysis. The results show that Zr-based bulk metallic glass has good groove milling machinability. The test results provide some experimental basis for groove milling of Zr-based bulk metallic glass.