bluuebunny/crossref_metadata_2025_split huggingface dataset:
MINCE
Authors: Cescutti G. , Bonifacio P. , Caffau E. , Monaco L. , Franchini M. , Lombardo L. , Matas Pinto A. M. , Lucertini F. , François P. , Spitoni E. , Lallement R. , Sbordone L. , Mucciarelli A. , Spite M. , Hansen C. J. , Di Marcantonio P. , Kučinskas A. , Dobrovolskas V. , Korn A. J. , Valentini M. , Magrini L. , Cristallo S. , Matteucci F. 
Published: October 2022

Context. In recent years, Galactic archaeology has become a particularly vibrant field of astronomy, with its main focus set on the oldest stars of our Galaxy. In most cases, these stars have been identified as the most metal-poor. However, the struggle to find these ancient fossils has produced an important bias in the observations – in particular, the intermediate metal-poor stars (−2.5 < [Fe/H] < −1.5) have been frequently overlooked. The missing information has consequences for the precise study of the chemical enrichment of our Galaxy, in particular for what concerns neutron capture elements and it will be only partially covered by future multi object spectroscopic surveys such as WEAVE and 4MOST.
Aims. Measuring at Intermediate Metallicity Neutron Capture Elements (MINCE) is gathering the first high-quality spectra (high signal-to-noise ratio, S/N, and high resolution) for several hundreds of bright and metal-poor stars, mainly located in our Galactic halo.
Methods. We compiled our selection mainly on the basis of Gaia data and determined the stellar atmospheres of our sample and the chemical abundances of each star.
Results. In this paper, we present the first sample of 59 spectra of 46 stars. We measured the radial velocities and computed the Galactic orbits for all stars. We found that 8 stars belong to the thin disc, 15 to disrupted satellites, and the remaining cannot be associated to the mentioned structures, and we call them halo stars. For 33 of these stars, we provide abundances for the elements up to zinc. We also show the chemical evolution results for eleven chemical elements, based on recent models.
Conclusions. Our observational strategy of using multiple telescopes and spectrographs to acquire high S/N and high-resolution spectra for intermediate-metallicity stars has proven to be very efficient, since the present sample was acquired over only about one year of observations. Finally, our target selection strategy, after an initial adjustment, proved satisfactory for our purposes.
The miniJPAS Survey: Detection of the double-core Lyα morphology for two high-redshift QSOs
Authors: Rahna P. T. , Zheng Z.-Y. , Chies-Santos A. L. , Cai Z. , Spinoso D. , Marquez I. , Overzier R. , Abramo L. R. , Bonoli S. , Kehrig C. , Díaz-García L. A. , Pović M. , Soria R. , Diego J. M. , Broadhurst T. , González Delgado R. M. , Alcaniz J. , Benítez N. , Carneiro S. , Cenarro A. J. , Cristóbal-Hornillos D. , Dupke R. A. , Ederoclite A. , Hernán-Caballero A. , López-Sanjuan C. , Marín-Franch A. , Mendes de Oliveira C. , Moles M. , Sodré L. , Taylor K. , Varela J. , Vázquez Ramió H. ,   JPAS team
Published: October 2022

Context. The Lyα emission is an important tracer of neutral gas in a circum-galactic medium (CGM) around high-z quasi-stellar objects (QSOs). The origin of Lyα emission around QSOs is still under debate, bringing on significant implications for galaxy formation and evolution.
Aims. In this paper, we study Lyα nebulae around two high redshift QSOs, SDSS J141935.58+525710.7 at z = 3.218 (hereafter QSO1) and SDSS J141813.40+525240.4 at z = 3.287 (hereafter QSO2), from the miniJPAS survey within the All-wavelength Extended Groth Strip International Survey (AEGIS) field.
Methods. Using the contiguous narrow-band (NB) images from the miniJPAS survey and Sloan Digital Sky Survey (SDSS) spectra, we analyzed their morphology, nature, and origin.
Results. We report the serendipitous detection of double-core Lyα morphology around two QSOs, which is rarely seen among other QSOs. The separations of the two Lyα cores are 11.07 ± 2.26 kpcs (1.47 ± 0.3″) and 9.73 ± 1.55 kpcs (1.31 ± 0.21″), with Lyα line luminosities of ∼3.35  ×  1044 erg s−1 and ∼6.99  ×  1044 erg s −1 for QSO1 and QSO2, respectively. The miniJPAS NB images show evidence of extended Lyα and CIV morphology for both QSOs and extended HeII morphology for QSO1.
Conclusions. These two QSOs may be potential candidates for the new enormous Lyman alpha nebula (ELAN) found from the miniJPAS survey due to their extended morphology in the shallow depth and relatively high Lyα luminosities. We suggest that galactic outflows are the major powering mechanism for the double-core Lyα morphology. Considering the relatively shallow exposures of miniJPAS, the objects found here could merely form the cusp of a promising number of such objects that will be uncovered in the upcoming full Javalambre-Physics of the Accelerated Universe Astrophysical Survey (J-PAS) survey and deep integral field units (IFU) observations with 8–10 m telescopes will be essential for constraining the underlying physical mechanism that is responsible for the double-cored morphology.
Krise3 – Auswirkungen des Russland-Ukraine-Krieges
während der Corona-Pandemie inmitten des Klimawandels auf
Phytotherapeutika
Authors: Reiken Babette 
Published: October 2022

Pragmatische Lösungen dringend gesucht!Während der andauernden Corona-Pandemie, die uns die Abhängigkeiten
der weltweiten Lieferketten vor Augen führt und in der inzwischen jeder die
katastrophalen Folgen des Klimawandels spürt, stecken wir seit dem Ausbruch
des Russland-Ukraine-Krieges inmitten einer Zeitenwende, die uns sowohl
gesellschaftlich als auch ökonomisch vor große Herausforderungen
stellt.
The Evolution of Miasm Theory and Its Relevance to Homeopathic Prescribing
Authors: Vithoulkas George , Chabanov Dmitry 
Published: October 2022

AbstractFor most health professionals who have chosen the challenging path of comprehending classical homeopathy, the theory of miasms is the most intriguing part of our science and is an area where much misunderstanding, criticism and controversy prevails. There are now a large number of opposing ideas and opinions on the subject of miasms, with various classifications, many of which we believe to be erroneous and which confuse many homeopaths and result in incorrect prescriptions.Here we clarify the main postulates of Hahnemann's miasm theory and analyse how his followers transformed his ideas over the next century in the light of medical discoveries. This allows us to understand the limited relevance of miasm theory to modern day prescribing and offer a new and precise definition of the term miasm in relation to modern diseases such as cancer and autoimmune diseases. How we apply this theory to the health challenges of the 21st century, such as increasing environmental pollution and other toxins, may play an important role in the future wellbeing of the human population.
Chronic Thromboembolic Pulmonary Disease and Chronic Thromboembolic Pulmonary Hypertension
Authors: Remy-Jardin Martine , Hutt Antoine , Remy Jacques 
Published: October 2022

AbstractChronic thromboembolic pulmonary hypertension (CTEPH) and chronic thromboembolic pulmonary disease (CTEPD) are two terms characterizing symptomatic patients with chronic thromboembolic occlusions of pulmonary arteries with or without pulmonary hypertension at rest. Their diagnosis follows evolving schemas that integrate technological advances of pivotal imaging modalities among which computed tomography angiography plays a major role. This review article summarizes the current knowledge on the natural history of acute pulmonary embolism and its evolution toward chronic pulmonary embolism, as well as the imaging clues, for the identification of chronically obstructed pulmonary arteries. The requirements for imaging at the time of therapeutic decisions are also described in the light of recent updates in the literature from multidisciplinary groups of experts. Because an early diagnosis of CTEPH remains a challenge for the medical community, several practical issues are included in this article with the objective of improving the knowledge and collaboration between radiologists and clinicians in service to the patient.
Is Further Evaluation of Areas with Faint MDP Uptake Needed in Individuals with Oligo-Metastatic Prostatic Adenocarcinoma?
Authors: Sharma Anshul , Dwivedi Ankur 
Published: October 2022

AbstractA 42-year-old male patient with high-risk prostate adenocarcinoma underwent baseline 99mTc-methylene diphosphonate skeletal scintigraphy, which revealed two skeletal metastases and an area of faint radiotracer uptake in the left femoral shaft. In view of oligo-metastatic nature of the disease in the bone scan and the young age of the patient, he was a candidate for metastases-directed treatment. Single photon emission computed tomography (SPECT)/CT was performed to further characterize this lesion. It was revealed to be a small soft tissue density lesion within the fatty bone marrow density, suggesting bone marrow involvement. A more sensitive evaluation of such areas with faint radiotracer uptake may be needed in high-risk prostate cancer patients where access to advanced modalities is limited. Their significance will also need reassessment as their detection will improve with technological advancements.
Assessment of Hearing Loss in Minor Head Injury: A Prospective Study
Authors: Bansal Sumit , Preetam Chappity , Patnaik Ashis , Sahu Rabi Narayan 
Published: October 2022

Abstract
Introduction Hearing loss following a head injury is common and well known. The numbers of road traffic accidents have increased recently, with minor head injuries being very common, and usually go unreported. Hearing loss after a minor head injury is often unnoticed. Available literature is limited in this regard.
Objective This study was done to assess hearing loss in patients with minor head injuries and to define its natural history and progression/regression by a serial assessment of hearing.
Methods This prospective study was done in the Department of Neurosurgery, AIIMS, Bhubaneshwar, Odisha, India, for a period of 24 months to look at the profile of hearing levels of patients presenting with history suggestive of minor head injury.
Results This study has shown that some form of hearing loss is common after a minor head injury and should be evaluated in all patients to detect subclinical hearing loss. A significant number of patients having minimal or a mild degree of hearing loss, if managed properly, improve to preinjury status. Distortion product oto-acoustic emission testing should be used as the screening and follow-up tool.
Conclusion This study highlights the importance of hearing assessment in minor-head-injury patients and the prognosis of recovery as per the severity of hearing loss and head injury.
Primary Leptomeningeal Medulloblastoma in Adults: A Diagnostic Challenge—Case Report and Systematic Review
Authors: Fabbro Sara , Pegolo Enrico , Piccolo Daniele , Cramaro Antonio , Mascarin Maurizio , Coassin Elisa , Skrap Miran , Tuniz Francesco 
Published: October 2022

AbstractPrimary leptomeningeal medulloblastoma (PL-MB) in adults is a rare disease with a severe prognosis. A 35-year-old woman presented with headaches, diplopia, and gait ataxia, with triventricular hydrocephalus and descent of the cerebellar tonsils beyond the foramen magnum. Endoscopic third ventriculostomy was performed. Six months later, headaches recurred. Dilatation of the supratentorial ventricular system and massive cerebellar swelling without contrast-enhancing nodularities were reported. Occipitocervical decompression with duraplasty was performed. A bioptic diagnosis of PL-MB was made. Craniospinal irradiation and chemotherapy were administered. After 18 months, no recurrence was observed.Few cases of PL-MB have been reported: patients die before treatment or within a few days after surgery. Our long-term survival could be ascribable to a slow clinical presentation and an early diagnosis that allowed surgical treatment and the administration of a combined chemoradiotherapy protocol. Cerebellar swelling, even without associated enhancing lesions, with or without hydrocephalus, should be a neuroradiological alarm sign, and PL-MB should be considered.
Obesity-related glomerulopathy in children: connecting pathophysiology to clinical care
Authors: Mangat Guneive , Nair Nikhil , Barat Oren , Abboud Brian , Pais Priya , Bagga Sumedha , Raina Rupesh 
Published: October 2022

ABSTRACTObesity has continued to emerge as a worldwide pandemic and has been associated with a significant increase in associated comorbidities. These include well-known conditions such as hypertension and diabetes, as well as lesser-known conditions such as obesity-related glomerulopathy (ORG). The main etiology of ORG is podocyte damage, but contributing theories include dysfunctional renin–angiotensin–aldosterone system activation, hyperinsulinemia and lipid deposition. Recent advances have made strides in understanding the complex pathophysiology of ORG. The key to treating ORG is weight loss and proteinuria reduction. Lifestyle modification, pharmacological interventions and surgery are mainstays of management. A special focus on obese children is required, as childhood obesity tracks into adulthood and primary prevention is key. In this review we discuss the pathogenesis, clinical features and established and newer treatment modalities of ORG.
Prescription of benzodiazepines and Z-drugs among older patients in primary care: a French, national, cohort study
Authors: Yana Jonathan , Moscova Laura , Le Breton Julien , Boutin Emmanuelle , Siess Tiphaine , Clerc Pascal , Bastuji-Garin Sylvie , Ferrat Emilie 
Published: October 2022

Abstract

Background
In France, general practitioners (GPs) prescribe benzodiazepines and Z-drugs (BZD/ZDs) widely, and especially to older adults. Several characteristics of patients and/or GPs linked to BZD/ZD overprescription have been described in the general population but not among older patients in primary care.

Objectives
To estimate the proportion of GP consultations by patients aged 65 and over that resulted in a BZD/ZD prescription, and determine whether any GP-related factors predicted BZD/ZD overprescription in this setting.

Methods
We analyzed sociodemographic and practice-related GP characteristics, and aggregated data on consultations recorded prospectively by 117 GPs in a database between 2000 and 2010. Next, we used logistic regression models to look for factors potentially associated with BZD/ZD overprescription (defined as an above-median prescription rate).

Results
The GPs’ mean age at inclusion was 47.4 (7.1), and 87.9% were male. During the study period, the median (95% confidence interval) proportion of consultations with patients aged 65 and over resulting in a BZD/ZD prescription was 21.8% (18.1–26.1) (range per GP: 5–34.1%). In a multivariable analysis, a greater number of chronic disease (OR [95% CI] = 2.10 [1.22–3.64]), a greater number of drugs prescribed per consultation (5.29 [2.72–10.28]), and shorter study participation were independently associated with BZD/ZD overprescription.

Conclusions
BZD/ZD overprescription was associated with a greater chronic disease burden and the number of drugs prescribed per consultation but not with any sociodemographic or practice-related GP characteristics. Targeted actions are needed to help GPs limit their prescription of BZD/ZDs to older patients with multiple comorbidities and polypharmacy.
TFIIH mutations can impact on translational fidelity of the ribosome
Authors: Khalid Fatima , Phan Tamara , Qiang Mingyue , Maity Pallab , Lasser Theresa , Wiese Sebastian , Penzo Marianna , Alupei Marius , Orioli Donata , Scharffetter-Kochanek Karin , Iben Sebastian 
Published: October 2022

AbstractTFIIH is a complex essential for transcription of protein-coding genes by RNA polymerase II, DNA repair of UV-lesions and transcription of rRNA by RNA polymerase I. Mutations in TFIIH cause the cancer prone DNA-repair disorder xeroderma pigmentosum (XP) and the developmental and premature aging disorders trichothiodystrophy (TTD) and Cockayne syndrome. A total of 50% of the TTD cases are caused by TFIIH mutations. Using TFIIH mutant patient cells from TTD and XP subjects we can show that the stress-sensitivity of the proteome is reduced in TTD, but not in XP. Using three different methods to investigate the accuracy of protein synthesis by the ribosome, we demonstrate that translational fidelity of the ribosomes of TTD, but not XP cells, is decreased. The process of ribosomal synthesis and maturation is affected in TTD cells and can lead to instable ribosomes. Isolated ribosomes from TTD patients show an elevated error rate when challenged with oxidized mRNA, explaining the oxidative hypersensitivity of TTD cells. Treatment of TTD cells with N-acetyl cysteine normalized the increased translational error-rate and restored translational fidelity. Here we describe a pathomechanism that might be relevant for our understanding of impaired development and aging-associated neurodegeneration.
Clinical perspectives on the menstrual pictogram for the assessment of heavy menstrual bleeding
Authors: Singh Sukhbir S , Calaf Alsina Joaquin , Vannuccini Silvia , Koga Kaori , Lopes Silva-Filho Agnaldo , Yang Xin , Estrade Jean-Philippe , Catherino William 
Published: October 2022

Abstract
Heavy menstrual bleeding (HMB) has an estimated prevalence of 18–32% but is known to be under-reported due to poor recognition and estimation of menstrual blood loss (MBL). HMB can negatively impact quality of life, affecting social interactions, work productivity and sexual life. Abnormal menstrual bleeding may have an underlying structural or systemic cause, such as endometrial and myometrial disorders; however, for some, there is no identified pathological cause. Several methods are available for assessing MBL, including the alkaline hematin (AH) method and the menstrual pictogram (MP). The AH method is considered to be the most accurate way to monitor MBL; however, it is associated with inconvenience and expense, therefore limiting its value outside of research. The MP requires the user to select an icon from a chart that reflects the appearance of a used sanitary product; the icon is associated with a blood volume that can be used to determine MBL. Validation studies have demonstrated that the results of the MP and AH method are well correlated, showing that the MP can measure MBL with sufficient accuracy. Additionally, the MP is more convenient for users, less expensive than the AH method, may be used in regions where the AH method is unavailable and may also be used as part of a digital application. Overall, the MP offers a convenient approach to monitor MBL both in research and clinical practice settings.
Congenital aortocaval fistula combined with patent ductus arteriosus in an infant: a case report
Authors: Jiao Xianting , Zhao Liqing , Wu Yurong , Chen Sun 
Published: October 2022

Abstract
Congenital aortocaval fistula (ACF) is a rare cardiac malformation. While it can occur in combination with patent ductus arteriosus (PDA), this has not been reported. In this case, a 1-year-old infant had a heart murmur found in a routine physical examination, and PDA was revealed by transthoracic echocardiography and abdominal ACF was detected by three-dimensional coronary artery computed tomography. Percutaneous interventional therapy, used for ACF and PDA, was performed to occlude the malformation. The patient presented good health without any discomfort at a 1-year follow-up. The percutaneous closure of ACF and PDA with an Amplatzer vascular device can be considered an appropriate option.
In vitro activity of fosfomycin alone and in combination against Staphylococcus aureus with reduced susceptibility or resistance to methicillin, vancomycin, daptomycin or linezolid
Authors: Saravolatz Louis D , Pawlak Joan 
Published: October 2022

Abstract

Objectives
To evaluate the activity of fosfomycin against a group of MRSA strains, including isolates with reduced susceptibility or resistance to vancomycin, daptomycin, linezolid and ceftaroline and to determine the effect of combining various combinations of antimicrobial agents used in the therapy of serious Gram-positive infections.

Methods
Broth microdilution testing was used to determine the MICs of fosfomycin, vancomycin, daptomycin, linezolid, ceftaroline and cefazolin. Isolates were selected for further evaluations to determine in vitro synergy between fosfomycin and select antimicrobial agents using chequerboard broth microdilution testing. Fosfomycin was tested in combination with vancomycin, linezolid, daptomycin, ceftaroline and cefazolin.

Results
Fosfomycin maintained activity against 100% of strains of vancomycin-resistant Staphylococcus aureus (VRSA) and linezolid-resistant S. aureus (LRSA), 86% of VISA and 95% of daptomycin-resistant S. aureus (DRSA) strains. The combination of fosfomycin with ceftaroline consistently demonstrated synergy among all 18 isolates against the strains tested. The next most potent combination regimen was linezolid with fosfomycin, which demonstrated synergy in 16 of the 18 strains. Daptomycin demonstrated synergy in only 7 of the 18 strains tested when combined with fosfomycin. Cefazolin demonstrated synergy in 6 of 6 strains and vancomycin demonstrated no interaction in 6 of 6 strains tested.

Conclusions
Fosfomycin demonstrated excellent activity against MRSA as well as isolates with resistance or reduced activity to other anti-MRSA drugs including vancomycin, daptomycin and linezolid. When combined with linezolid or daptomycin, fosfomycin demonstrated synergy for all or most strains tested. Thus, these combinations may have potential clinical utility when treating patients with serious infections caused by MRSA.
How iconic news images travel: republishing and reframing historic photographs in Israeli newspapers
Authors: Boudana Sandrine , Cohen Akiba A , Frosh Paul 
Published: October 2022

AbstractIconic photographs are symbolically dense images characterized by broad circulation over time and recognition by large publics. Following this definition, we track the republication and reframing, over nearly 70 years, of 15 news photographs previously identified as most recognized by the Israeli public. Distinguishing between “discrete icons” (singular photographs of particular scenes) and “aggregate icons” (where several variants of the same event are continually reproduced), our quantitative and qualitative analyses show that iconic images are both resistant to the passing of time and kept in motion through renewed media use. We identify four “iconic modalities,” corresponding to different ways in which iconic status and meanings are achieved, transformed, or denied through republishing and reframing. This concept improves our understanding of iconicity as a fluctuating material and symbolic process, whereby the circulation of images not only produces shifts in meaning, but constructs powerful aggregative frameworks of collective visual memory.