bluuebunny/crossref_metadata_2025_split huggingface dataset:
RNA‐seq profiling of tubulointerstitial tissue reveals a potential therapeutic role of dual anti‐phosphatase 1 in glomerulonephritis
Authors: Park Sehoon , Lee Hajeong , Lee Jeongha , Lee Sangmoon , Cho Semin , Huh Hyeok , Kim Joo Young , Park Minkyoung , Lee Soojin , Kim Yaerim , Choi Murim , Joo Kwon Wook , Kim Yon Su , Yang Seung Hee , Kim Dong Ki 
Published: April 2022

AbstractTranscriptome profiling of tubulointerstitial tissue in glomerulonephritis may reveal a potential tubulointerstitial injury‐related biomarker. We profiled manually microdissected tubulointerstitial tissue from biopsy cores of 65 glomerulonephritis cases, including 43 patients with IgA nephropathy, 3 with diabetes mellitus nephropathy, 3 with focal segmental glomerulosclerosis, 3 with lupus nephritis, 4 with membranous nephropathy and 9 with minimal change disease, and additional 22 nephrectomy controls by RNA sequencing. A potential biomarker was selected based on the false discovery rate, and experiments were performed in TNF‐α‐stimulated primary cultured human tubular epithelial cells (hTECs). We identified 3037 genes with low expression and 2852 genes with high expression in the disease samples compared to the controls. Dual‐specificity phosphatase 1 (DUSP1) exhibited universal low expression in various diseases (log2 fold change, −3.87), with the lowest false discovery rate (7.03E‐132). In further experimental validation study, DUSP1 overexpression ameliorated inflammatory markers related to MAP kinase pathways in hTECs, while pharmacologic inhibition of DUSP1 increased these markers. The combination of DUSP1 overexpression with low‐concentration corticosteroid treatment resulted in more potent suppression of inflammation than high‐concentration corticosteroid treatment alone. The profiled transcriptomes provide insights into the pathophysiology of tubulointerstitial injury in kidney diseases and may reveal a potential therapeutic biomarker.
Which two heads are better than one? Uncovering the positive effects of diversity in creative teams
Authors: Dutcher Glenn , Rodet Cortney S. 
Published: April 2022

AbstractWe examine how diversity affects teams' output in the creative uses task. Diversity among team members' experience or knowledge leads to greater creative output; however, diversity over observable characteristics has no measurable impact. Surprisingly, we find no correlation between experiential diversity and diversity over observable characteristics in our sample. We propose that creative organizations can benefit by also emphasizing experiential diversity when constructing diversity policy to foster effective teams.
Regional differences in vertebral shape along the axial skeleton in caecilians (Amphibia: Gymnophiona)
Authors: Lowie Aurélien , De Kegel Barbara , Wilkinson Mark , Measey John , O'Reilly James C. , Kley Nathan J. , Gaucher Philippe , Brecko Jonathan , Kleinteich Thomas , Herrel Anthony , Adriaens Dominique 
Published: April 2022

AbstractCaecilians are elongate, limbless and annulated amphibians that, as far as is known, all have an at least partly fossorial lifestyle. It has been suggested that elongate limbless vertebrates show little morphological differentiation throughout the postcranial skeleton. However, relatively few studies have explored the axial skeleton in limbless tetrapods. In this study, we used μCT data and three‐dimensional geometric morphometrics to explore regional differences in vertebral shape across a broad range of caecilian species. Our results highlight substantial differences in vertebral shape along the axial skeleton, with anterior vertebrae being short and bulky, whereas posterior vertebrae are more elongated. This study shows that despite being limbless, elongate tetrapods such as caecilians still show regional heterogeneity in the shape of individual vertebrae along the vertebral column. Further studies are needed, however, to understand the possible causes and functional consequences of the observed variation in vertebral shape in caecilians.
Outcomes of 1064‐nm picosecond laser alone and in combination with fractional 1064‐nm picosecond laser in tattoo removal
Authors: Sirithanabadeekul Punyaphat , Vongchansathapat Passaraporn , Sutthipisal Nalinee , Thanasarnaksorn Wilai , Suwanchinda Atchima 
Published: April 2022

AbstractBackgroundRemoval of the unwanted tattoo was initially focused treatment of picosecond laser in the setting of the unfractionated beam, whereas the fractionated 1064‐nm picosecond lasers (Fr‐Pico) has been successfully utilized in various skin conditions, including scar and benign pigmented lesions. However, no studies compared the combination of Fr‐Pico and unfractional 1064‐nm picosecond laser (UFr‐Pico) and UFr‐Pico alone in tattoo removal.ObjectiveThis study aims to compare the efficacy and safety of the combination of Fr‐Pico and UFr‐Pico and the UFr‐Pico and in tattoo removal.Materials and methodsNineteen black tattoos in 11 patients were treated with UFr‐Pico on one half and in combination with Fr‐Pico on another half over three sessions with 4‐week intervals and 4‐week follow‐up after the last session. Treatment efficacy was assessed using digital photographs, skin imaging analysis, and patient satisfaction.ResultsAfter three treatments, tattoo clearance scores revealed that greater than 50% clearance was achieved in 11 (84.6%) tattoos treated with combination side and 9 (69.2%) tattoos with UFr‐Pico alone. Significant differences were observed between the groups at 8 and 12 weeks. Skin textural changes also demonstrated significant improvements in the combination side at Week 12. Adverse events, such as blistering and textural changes, were fewer in the combination side.ConclusionThe combination of 1064 nm Fr‐Pico and UFr‐Pico may be more effective and safer in tattoo removal than UFr‐Pico alone.
Toward a Historical Sociology of COVID‐19: Path Dependence Method and Temporal Connections
Authors: Ru Sung Hee 
Published: April 2022

AbstractEncountering the unprecedented social crisis of COVID‐19, an increasing number of sociologists are calling for historical sociology to engage empirically with the dynamics of the COVID‐19 crisis. I present the “path dependence method” and the “temporal connections” to interpret social life during the COVID‐19 pandemic. By using the path dependence method, I show how the personal, social, and national problems created by the COVID‐19 crisis initiate a new path and furthermore how this newly created path is justified in a society. Through the temporal connections, I will show how non‐Western countries responded more reasonably and quickly than most Western countries to the COVID‐19 crisis. The overall aim of this research is to disclose effectiveness of historical sociology, to encourage researchers to think time variable, and to argue that linking historical‐sociological knowledge to the COVID‐19 crisis would be a positive step for an in‐depth COVID‐19 sociology.
Critical update, systematic review, and meta‐analysis of oral erythroplakia as an oral potentially malignant disorder
Authors: Lorenzo‐Pouso Alejandro I. , Lafuente‐Ibáñez de Mendoza Irene , Pérez‐Sayáns Mario , Pérez‐Jardón Alba , Chamorro‐Petronacci Cintia M , Blanco‐Carrión Andrés , Aguirre‐Urízar José Manuel 
Published: April 2022

AbstractBackgroundOral erythroplakia has been classically considered as the potentially malignant disorder with the highest rate of malignant development into squamous cell carcinoma. This critical systematic review and meta‐analysis aim to estimate the malignant development rate of oral erythroplakia and identify the associated risk factors.MethodsWe performed a bibliographic search in PubMed, Scopus, Web of Science, Embase, and LILACS, with keywords “erythroplakia,” “erythroplasia,” “malignant transformation,” “malignant development,” “malignization,” “carcinogenesis,” “oral cancer,” “oral squamous cell carcinoma,” “mouth neoplasm,” and “prognosis.” Meta‐analysis was conducted using a random‐effects model.ResultsTen observational studies with 441 patients met the inclusion criteria, whose mean malignant development rate was 12.7% and with a mean follow‐up period of patients of 6.66 years. In the initial biopsy, 42.8% of oral erythroplakia were already squamous cell carcinoma. The buccal mucosa was the most frequent location of oral erythroplakia, but the floor of the mouth was the most common site of malignant development. All patients who underwent malignant development showed epithelial dysplasia on the initial diagnostic biopsy.ConclusionOverall malignant development rate of OE in the meta‐analysis was 19.9%. We could not associate any specific clinicopathological feature with the malignant development. The presence of epithelial dysplasia in the initial biopsy remains the worst prognostic factor. Further observational studies on OE are needed, with well‐established diagnostic criteria and good clinical follow‐up, in order to identify the true risk of malignant development of oral erythroplakia and the related risk factors.
PP2C1 fine‐tunes melatonin biosynthesis and phytomelatonin receptor PMTR1 binding to melatonin in cassava
Authors: Bai Yujing , Wei Yunxie , Yin Hongyan , Hu Wei , Cheng Xiao , Guo Jingru , Dong Yabin , Zheng Liyan , Xie Haoqi , Zeng Hongqiu , Reiter Russel J. , Shi Haitao 
Published: April 2022

AbstractMelatonin is an important molecule in both animals and plants, regulating circadian rhythms and stress responses. Therefore, the improvement of melatonin accumulation not only strengthens the function of melatonin but also improves stress resistance in crops. Although melatonin biosynthetic enzymes have been identified through reverse genetics previously, an investigation of melatonin level‐related genes through forward genetics in plants has yet to be performed. In this study, a genome‐wide association study using cassava natural population of 298 genetic resources identified melatonin accumulation 1 (MA1), which regulates the natural variation of melatonin levels in cassava. We found that MA1 encodes type 2C protein phosphatase 1 (PP2C1), which serves as a negative regulator of melatonin levels in cassava. MePP2C1 physically interacts with MeRAV1/2 and MeWRKY20 and dephosphorylates them at serine (S) 35 residue, S34 residue, and S176 residue, respectively, thereby hindering their transcriptional activation on downstream melatonin biosynthetic genes. Notably, MePP2C1 interacts with phytomelatonin receptor MePMTR1 and dephosphorylates it at S11 residue, repressing its binding to melatonin. In summary, this study demonstrates that MePP2C1 as MA1 plays dual roles in negatively regulating both melatonin accumulation and signaling, extending the understanding of the molecular mechanism underlying melatonin accumulation and signaling through forward genetics in plants.
Association of sleep with moral severity to accidental harm transgressions: A cross‐sectional study
Authors: Trémolière Bastien , Schwartz Flora , Gosling Corentin J. 
Published: April 2022

SummaryBased on the assumptions that moral judgement activities require cognitive control, a capacity impaired by low sleep quality or a lack of sleep, several studies have explored the association between sleep and moral judgements. However, even if some studies support the association between sleep and both moral awareness and unethical behaviours, others failed to find a robust association between sleep and moral utilitarianism. In the present well‐powered preregistered cross‐sectional study, we explored the role of sleep in another class of moral judgement, namely third‐party punishment (in which people have to assess the morality of an agent who transgressed a moral rule). Specifically, we targeted the association of sleep with judgements of accidental harm transgressions, which are assumed to be especially cognitively costly. Our main analysis showed no association of overall sleep quality during the past month with moral severity in these transgressions. This result was confirmed for other sleep indexes (sleep quantity in the past month, and sleep quantity and quality in the past night). Lastly, we exhaustively explored the associations of all sleep indexes with all classes of moral judgement (accidental, intentional, attempted transgressions and control scenarios). These additional results revealed associations between sleep and moral severity, but none survived correction for multiple testing. Equivalence tests confirmed that the effect sizes of all these associations were relatively low (|r < 0.25|). We ensured that the lack of robust association between natural sleep and third‐party punishment could not be explained by a low quality of the data collected.
Social psychology as a stable interpretative framework irrefutably committed to the scientific study of persons and society
Authors: Barnes Collin D. 
Published: April 2022

AbstractDespite repeated opportunities to reconsider their natural science ambitions, social psychologists have not done so, and there are no obvious signs of this changing. Why? This paper pursues an answer to this question by defining the field after the fashion of Michael Polanyi's thought. According to Polanyi, interpretative frameworks develop from our primitive bodily encounters with the world and then are shaped by language into the vast conceptual systems of our culture. Concerning frameworks erected on our most fundamental beliefs (e.g., science), he says that we “live in [them] as in the garment of our own skin.” Frameworks such as this are not objects of critical evaluation but of commitment, and social psychology, as an outgrowth of positive philosophy, is an interpretative framework in this sense. Professionals' recent responses to the field's political makeup and replication failures demonstrate this. They aim primarily at preserving a natural science understanding of social psychology and point to the influence of belief‐stabilizing mechanisms Polanyi finds operative in folk religious practices. These mechanisms appear at work also in psychology as a whole. They are implied, for instance, in the field's resistance to Sigmund Koch's authoritative judgement against its scientific self‐conception in the latter half of the 20th century. Noting this reveals the broader implications of this paper's definition of social psychology, but it also urges questions about truth and relativity that cannot be ignored. These questions are addressed briefly in the end where it is suggested that what psychology needs most of all is a change of heart, and that this will happen, if at all, not primarily through argument and evidence, but through persons who authentically believe in the veracity of a different framework.
The seasonal relationships between household dietary diversity and child growth in a rural Timor‐Leste community
Authors: Guizzo Dri Gabriela , Spencer Phoebe R. , da Costa Raimundo , Sanders Katherine A. , Judge Debra S. 
Published: April 2022

AbstractBoth child growth and dietary diversity are poor in rural Timor‐Leste. The rainy season is associated with food scarcity, yet the association between seasonal scarcity, food diversity, and child growth is underdocumented. This study assesses the relationship between household dietary diversity and children's standardized growth across the 2018 food‐scarce (April–May; post‐rainy period) and post‐harvest (October) seasons in the agricultural community of Natarbora, on the south‐coastal plains of Timor‐Leste. We conducted household interviews and collected anthropometric data across 98 and 93 households in the post‐rainy and post‐harvest periods, respectively. Consumed household foods were obtained via 24‐h diet recalls and were subsequently categorized into a nine‐food‐group dietary diversity score (DDS; number of different food groups consumed). The DDS was related to children's standardized short‐term growth (z‐weight, z‐body mass index [BMI] and percent change in weight over the harvest season) via linear mixed models. Across seasons, DDS increased from 3.9 (standard deviation [SD] = 1.0) to 4.3 (SD = 1.4; p < 0.05). In the post‐rainy season, children in high DDS households had higher z‐weight than those in low DDS households and higher z‐BMI than children in medium and low DDS households. In the post‐harvest period, household DDS did not predict children's z‐weight but predicted z‐BMI. Consumption of protein‐rich foods, particularly animal‐source foods and legumes, in low‐ and medium‐DDS households may be associated with improved child growth. While consuming more animal‐source foods in the post‐rainy season would be ideal, promoting the consumption of locally grown legumes, such as beans and pulses, may facilitate better nutritional outcomes for more children in rural Timor‐Leste.
Predictors of prediabetes/diabetes and hypertension in Ethiopia: Reanalysis of the 2015 NCD STEPS survey using causal path diagrams
Authors: Norris Tom , Girma Meron , Genye Tirsit , Hussen Alemayehu , Pradeilles Rebecca , Bekele Zerihun , van Zyl Cornelia , Samuel Aregash 
Published: April 2022

AbstractThe objective of our study was to reanalyse the Ethiopia STEPwise approach to Surveillance Noncommunicable Disease Risk Factors survey (NCD STEPS), using causal path diagrams constructed using expert subject matter knowledge in conjunction with graphical model theory to map the underlying causal network of modifiable factors associated with prediabetes/diabetes and hypertension. We used data from the 2015 Ethiopia NCD STEPS representative cross‐sectional survey (males; n = 3977 and females; n = 5823 aged 15–69 years) and performed directed acyclic graph‐informed logistic regression analyses. In both sexes, a 1‐unit higher in body mass index (BMI) and waist circumference (WC) were positively associated with prediabetes/diabetes (BMI: males: adjusted odds ratio [aOR]: 1.07 [95% confidence interval: 1.0, 1.1], females aOR: 1.03 [1.0, 1.1]; WC: males: aOR: 1.1 [0.9, 1.2], females: aOR: 1.2 [1.1, 1.3]) and hypertension (BMI: males: aOR: 1.2 [1.1, 1.2], females aOR: 1.1 [1.0, 1.1]; WC: males: aOR: 1.6 [1.4, 1.8], females: aOR: 1.3 [1.2, 1.5]). Although residing in urban settings was associated with higher odds of hypertension in both males (aOR: 1.79 [1.49, 2.16]) and females (aOR: 1.70 [1.49, 1.95]), it was only associated with prediabetes/diabetes in males (aOR: 1.56 [1.25, 1.96]). Males and females in pastoralist areas had lower odds of prediabetes/diabetes compared with their agrarian counterparts (males: aOR: 0.27 [0.14, 0.52], females: aOR: 0.31 [0.16, 0.58]). Physical activity was associated with lower odds of prediabetes/diabetes among females (aOR: 0.75 [0.58, 0.97]). Other diet‐related modifiable factors such as consumption of fruit and vegetable, alcohol or salt were not associated with either prediabetes/diabetes or hypertension. Our findings highlight the need to implement interventions that prevent overweight/obesity and nutrition‐related NCDs, particularly in urban areas.
Satellite DNA evolution in Corvoidea inferred from short and long reads
Authors: Peona Valentina , Kutschera Verena E. , Blom Mozes P. K. , Irestedt Martin , Suh Alexander 
Published: April 2022

AbstractSatellite DNA (satDNA) is a fast‐evolving portion of eukaryotic genomes. The homogeneous and repetitive nature of such satDNA causes problems during the assembly of genomes, and therefore it is still difficult to study it in detail in nonmodel organisms as well as across broad evolutionary timescales. Here, we combined the use of short‐ and long‐read data to explore the diversity and evolution of satDNA between individuals of the same species and between genera of birds spanning ~40 millions of years of bird evolution using birds‐of‐paradise (Paradisaeidae) and crow (Corvus) species. These avian species highlighted the presence of a GC‐rich Corvoidea satellitome composed of 61 satellite families and provided a set of candidate satDNA monomers for being centromeric on the basis of length, abundance, homogeneity and transcription. Surprisingly, we found that the satDNA of crow species rapidly diverged between closely related species while the satDNA appeared more similar between birds‐of‐paradise species belonging to different genera.
Stroke incidence and chronic kidney disease: A hospital‐based prospective cohort study
Authors: Wakasugi Minako , Yokoseki Akio , Wada Masakazu , Sanpei Kazuhiro , Momotsu Takeshi , Sato Kenji , Kawashima Hiroyuki , Nakamura Kazutoshi , Onodera Osamu , Narita Ichiei 
Published: April 2022

AbstractAimThis prospective cohort study aimed to (i) examine stroke incidence and stroke subtypes by chronic kidney disease (CKD) stage, (ii) examine whether CKD patients with or without proteinuria have a high risk of stroke independent of traditional cardiovascular risk factors, and (iii) determine precise estimates of stroke risk by CKD stage while accounting for competing mortality risk.MethodsParticipants were 2023 patients enrolled in the Project in Sado for Total Health between June 2008 and December 2016 (55% men; mean age, 69 years), of whom 52% had CKD (stage 1–2, 10%; G3a, 48%; G3b, 17%; G4–5, 11% and G5D, 14%).ResultsDuring a median follow‐up of 5.7 years, 157 participants developed stroke and 448 died without developing stroke. Most stroke cases were ischaemic among non‐dialysis‐dependent CKD participants, but the relative frequency of ischaemic stroke was near that of intracerebral haemorrhage among dialysis‐dependent CKD participants. After adjustment, stage 1–2 (hazard ratio [HR], 2.97; 95% confidence interval [CI], 1.60–5.51) and stage G3–5 participants with proteinuria (HR, 2.50; 95% CI, 1.56–4.02), but not stage G3–5 participants without proteinuria (HR, 0.64; 95% CI, 0.38–1.08), had a higher stroke risk compared to non‐CKD participants. In competing risk analyses, the association was attenuated but remained significant.ConclusionAlthough the distribution of stroke subtypes differed, CKD participants with proteinuria and those with CKD stage 5D had a 2‐ and 4‐times higher risk of stroke, respectively, than that of non‐CKD participants, after accounting for competing mortality risk and traditional risk factors.
Melatonin affects red deer spermatozoa motility and physiology in capacitating and non‐capacitating conditions
Authors: Fernández‐Alegre Estela , Lacalle Estíbaliz , Soriano‐Úbeda Cristina , Carlos Domínguez Juan , Casao Adriana , Martínez‐Pastor Felipe 
Published: April 2022

AbstractMelatonin affects sperm physiology, possibly through membrane receptors. Effects were tested at low concentrations (1 pM, 100 pM, 10 nM and 1 µM) in red deer epididymal spermatozoa as a model for high‐seasonality species. Samples were incubated with melatonin as uncapacitated or capacitating conditions (heparin) and evaluated for motility and physiology (flow cytometry). Most effects occurred at low concentrations (nM‐pM), mainly protecting from apoptosis and maintaining acrosomal integrity, suggesting a role for membrane receptors rather than a direct antioxidant effect. Intracellular calcium was not affected, differing from other studies and perhaps because of the epididymal origin. This study supports the relevance of melatonin on sperm physiology and could contribute to the application of reproductive technologies in wild ruminants.