bluuebunny/crossref_metadata_2025_split huggingface dataset:
Modification of Diet to Reduce the Stemness and Tumorigenicity of Murine and Human Intestinal Cells
Authors: May Stephanie , Greenow Kirsty R. , Higgins Adam T. , Derrick Anna V. , Taylor Elaine , Pan Pan , Konstantinou Maria , Nixon Colin , Wooley Thomas E. , Sansom Owen J. , Wang Li‐Shu , Parry Lee 
Published: September 2022

ScopeBlack raspberries (BRBs) have colorectal cancer (CRC) chemo‐preventative effects. As CRC originates from an intestinal stem cell (ISC) this study has investigated the impact of BRBs on normal and mutant ISCs.Methods and resultsMice with an inducible Apcfl mutation in either the ISC (Lgr5CreERT2) or intestinal crypt (AhCre/VillinCreERT2) are fed a control or 10% BRB‐supplemented diet. This study uses immunohistochemistry, gene expression analysis, and organoid culture to evaluate the effect of BRBs on intestinal homeostasis. RNAscope is performed for ISC markers on CRC adjacent normal colonic tissue pre and post BRB intervention from patients. 10% BRB diet has no overt effect on murine intestinal homeostasis, despite a reduced stem cell number. Following Apc ISC deletion, BRB diet extends lifespan and reduces tumor area. In the AhCre model, BRB diet attenuates the “crypt‐progenitor” phenotype and reduces ISC marker gene expression. In ex vivo culture BRBs reduce the self‐renewal capacity of murine and human Apc deficient organoids. Finally, the study observes a reduction in ISC marker gene expression in adjacent normal crypts following introduction of BRBs to the human bowel.ConclusionBRBs play a role in CRC chemoprevention by protectively regulating the ISC compartment and further supports the use of BRBs in CRC prevention.
Results of a 2‐year lifestyle intervention for type 2 diabetes: the Reach Ahead for Lifestyle and Health‐Diabetes randomized controlled trial
Authors: Wexler Deborah J. , Chang Yuchiao , Levy Douglas E. , Porneala Bianca , McCarthy Jeanna , Rodriguez Romero Anthony , Goldman Valerie , Copeland Paul M. , Steppel‐Reznik Jeanne , Delahanty Linda M. 
Published: September 2022

AbstractObjectiveThe Reach Ahead for Lifestyle and Health (REAL HEALTH)‐Diabetes study assessed the comparative effectiveness of two Look AHEAD (Action for Health in Diabetes)‐adapted lifestyle intervention (LI) arms targeting weight loss in type 2 diabetes compared with medical nutrition therapy (MNT) referral. At 1 year, LI had greater weight loss than MNT. This study reports outcomes at 24 (end of LI) and 36 months.MethodsParticipants (N = 211) with type 2 diabetes and BMI > 25 kg/m2 were randomly assigned to in‐person LI, telephone conference call LI, or MNT. The primary outcome was percentage weight change. Secondary outcomes included 5% and 10% weight loss, glycated hemoglobin (HbA1c), and patient‐reported outcomes.ResultsParticipants were 61.7 (SD 10.2) years old; 55% were female; 77% were non‐Hispanic White; and had mean (SD) weight of 98 (18.9) kg and mean (SD) HbA1c of 7.7% (1.2%). Mean (SD) weight change at 24 and 36 months was −4.4% (5.9%) and −4.4% (5.4%) in in‐person LI, −4.0% (5.8%) and −5.3% (6.4%) in telephone LI, and −3.1% (5.2%) and −5.8% (7.1%) in MNT, with no statistically significant difference in weight or HbA1c at 24 and 36 months. Compared with MNT, LI arms had favorable changes in patient‐reported outcomes related to learned dietary skills.ConclusionsThere were no differences in weight outcomes among LI participants compared with referral to MNT at the end of intervention or 1 year after its conclusion.
Multi‐functional structural supercapacitor based on manganese oxide‐hydroxide nanowires modified carbon fiber fabric electrodes
Authors: Zhao Yue , Xu Haibing , Cai Guangbin , Yan Chun , Liu Dong , Chen Gang , Zhu Yingdan 
Published: September 2022

AbstractCarbon fiber is an ideal candidate for preparing electrode of structural supercapacitors, while its low specific surface area is a vital factor which restricts energy storage performance. In this study, MnOOH nanowires (MnOOH‐NWs) are in‐situ deposited onto the woven carbon fiber fabric (WCF) surface through an effective one‐step hydrothermal treatment to prepare MnOOH‐NWs modified WCF (MnOOH‐NWs@WCF) structural supercapacitor with appreciable electrochemical performance. The areal capacitance of MnOOH‐NWs@WCF structural supercapacitor reaches 77.1 mF/cm2, which is two orders of magnitude higher than that made from neat WCF electrode. The increase in areal capacitance is primarily due to the presence of conductive networks and abundant ion storage sites constructed by the MnOOH‐NWs. Meanwhile, flexural strength and modulus of the MnOOH‐NWs@WCF structural supercapacitor are 30.3 MPa and 1.8 GPa, respectively. Interestingly, the resultant structural supercapacitor also enables electromagnetic interference (EMI) shielding based on the conductive networks constructed by the WCF and MnOOH‐NWs, and the maximum EMI‐shielding effectiveness (EMI‐SE) is 59.1 dB. Consequently, a highly integrated multi‐functional structural supercapacitor is developed, which cannot only be applied as energy storage module and load bearing component but can also be adopted to protect electronic devices from the electromagnetic pollution.
Programmable photonics for optical communications
Authors: Gonzalez Ana , Theodoras Jim 
Published: September 2022

AbstractAs the bandwidth requirements in communication networks continue to increase unabated, wafer level photonic integration is becoming key to miniaturizing components and increasing the number of functionalities, thereby replacing bulky systems. However, a variety of challenges such as long development times and high costs of fabrication are impeding the widescale adoption of this technology in the optical communication field.
Enhanced edge strength for augmented reality waveguide laser singulation
Authors: Gaab Andreas , Roeder Tobias , Hayet Quentin , Becker Alejandro 
Published: September 2022

AbstractWith a new enhanced nanoperforation (EnP) approach, Corning Laser Technologies can demonstrate an increase to 128 MPa B10 in edge strength (ES) for 1.8RI glass. This will help designers and manufacturers to meet the expectations of future AR applications.
Modified explicitly correlated Fock‐space coupled‐cluster method for modeling confined molecular systems
Authors: Bedniakov Aleksandr S. , Bokhan Denis , Trubnikov Dmitrii N. , Novakovskaya Yulia V. 
Published: August 2022

AbstractA model for calculation of the ground and excited state energies, single and double electron affinities and ionization potentials of a many‐electron system confined in a cavity with a finite boundary potential is presented. Additional integrals of explicitly correlated Fock‐space coupled‐cluster method are calculated numerically with the use of conventional Gaussian basis sets on the same type of fine grids as those used for one‐electron integrals, which represents a rational and efficient tool for modeling confined systems. The method is verified by an example of H, He, and LiH systems with spherical potential and applied to describing a representative set of diverse spin and orbital states of molecule and its ions. As the size of the system and so the total number of the basis functions are increased, the accuracy of predictions also increases. In the case of , the internuclear distance is shown to be shortened with the increase in the potential wall height, while the energy differences between , , and states change only slightly. Critical cavity radii are determined, which correspond to the spontaneous ionization of and the loss of an excess electron by .
Haystack hunting hints and locker room communication
Authors: Czumaj Artur , Kontogeorgiou George , Paterson Mike 
Published: August 2022

AbstractWe want to efficiently find a specific object in a large unstructured set, which we model by a random ‐permutation, and we have to do it by revealing just a single element. Clearly, without any help this task is hopeless and the best one can do is to select the element at random, and achieve the success probability . Can we do better with some small amount of advice about the permutation, even without knowing the target object? We show that by providing advice of just one integer in , one can improve the success probability considerably, by a factor. We study this and related problems, and show asymptotically matching upper and lower bounds for their optimal probability of success. Our analysis relies on a close relationship of such problems to some intrinsic properties of random permutations related to the rencontres number.
A Kinetic Model for the Generation and Annihilation of Thermally Induced Carrier Donors in a Semiconducting Metal‐Oxide Thin Film
Authors: Wang Yuqi , Jiang Wei , Xie Xinying , Xia Zhihe , Wong Man 
Published: September 2022

AbstractBased on a kinetic model involving oxidant diffusion and an oxidation‐reduction reaction, a 3‐parameter equation is derived relating the change in the concentration of thermally induced carrier donors in common metal‐oxide semiconductors (such as indium–gallium–zinc oxide and indium–tin–zinc oxide) to heat‐treatment time. The change in the concentration of such donors is characterized by measuring the shift in the turn‐on voltage of a thin‐film transistor subjected to heat treatments in different atmospheres for different durations. The model parameters are extracted using optimal curve‐fitting techniques, leading to the determination of relevant activation energies from the temperature dependence of the extracted parameters. The proposed model is found to be applicable to metal‐oxide semiconductors of different compositions. It is discovered that the generation of donors in a non‐oxidizing atmosphere is largely suppressed at a temperature below 250 °C, but the effective annihilation of the donors spans over a wider temperature range in an oxidizing atmosphere.
Efficacy and safety of hangekobokuto (Banxia‐houpo‐tang) in treating panic disorder: A pilot study
Authors: Nakajima‐Ohyama Kakusho Chigusa , Shizusawa Yoshie , Tanimukai Hitoshi 
Published: August 2022

AbstractAimThe prevalence of panic disorder in patients with comorbidities is higher than in the general population. Selective serotonin reuptake inhibitors (SSRIs) or benzodiazepines, the common pharmacotherapy, can cause adverse effects in the patients. To research other options, we report a retrospective pilot study on hangekobokuto in treating panic disorder.MethodsWe reviewed the data of consecutive cases with panic disorder treated with hangekobokuto from April 1, 2017 to March 31, 2021 at Kindai University Nara Hospital. The changes in the symptoms, assessed by the Panic Disorder Severity Scale (PDSS), and adverse events were investigated.ResultsThe total number of patients was 35 (8 males and 27 females). The median and the interquartile range (IQR) of age (years old) were 50 and 42.5–70. The mean and standard deviation (SD) of PDSS score were initially 14.51/28 (±4.76). They changed to 10.91/28 (±6.11) after one month, then 9.40/28 (±6.99) after three months (p < 0.05). After one month 19 patients (54.3%) and after three months 23 patients (65.7%) saw an improvement with a decrease of PDSS score equal to or more than three points from the baseline. The middle‐aged group seemed to have shown the highest response to hangekobokuto. As adverse effects, one patient reported nausea and another diarrhea.ConclusionThe efficacy and safety of hangekobokuto for panic disorder are suggested in our study, but more research will be necessary.
A review on novel and hybrid/integrated reactor configurations for the removal of recalcitrant organics from petroleum refinery wastewater
Authors: Paul Tanushree , Janakiraman Iyyappan , Pakshirajan Kannan , Pugazhenthi Gopal 
Published: August 2022

AbstractOwing to the high demand of petroleum and petrochemical products, refineries, among the many industries that are set up worldwide, are of special importance. Wastewater generated from such industrial activities, however, contains toxic compounds that are of environmental concern. Due to the presence of highly recalcitrant organics present in refinery wastewater, treatment prior to its discharge into the environment and water bodies in order to meet certain acceptable discharge limits is imperative. Petroleum refineries unavoidably discharge a large volume of wastewater mainly with high chemical oxygen demand (COD). Low‐cost biological wastewater treatment methods are reported to show excellent COD removal efficiency from wastewater but have their own drawbacks. Hence, advanced integrated approaches are of new interest in this field. This review focuses on emerging technologies, in particular bioreactor configurations for petroleum wastewater treatment. It further discusses some future perspective in hybrid/integrated systems for treating PRWW.
Analyzing dual porosity in soil hydraulic properties using soil databases for pedotransfer function development
Authors: Zhang Yonggen , Weihermüller Lutz , Toth Brigitta , Noman Muhammad , Vereecken Harry 
Published: August 2022

AbstractCurrent databases of soil hydraulic properties (SHPs) have typically been used to develop pedotransfer functions (PTFs) to estimate water retention [θ(h)] assuming a unimodal pore‐size distribution. However, natural soils often show the presence of bimodal to multimodal pore‐size distributions. Here, we used three widely spread databases for PTF development: UNsaturated SOil hydraulic DAtabase (UNSODA) 2.0, Vereecken, and European hydropedological data inventory (EU‐HYDI), to analyze the presence of structural effects in both θ(h) and hydraulic conductivity [K(h)]. Only undisturbed samples were included in the analysis that contained enough datapoints for both θ(h) and K(h) properties, especially in the wet range. One‐hundred ninety‐two samples were suitable for our analysis, which is only 1% of the total samples in the three databases. Results showed that 65% of the samples exhibited a bimodal pore‐size distribution, and bimodality was not limited to fine‐textured but also coarser‐textured soils. The Mualem–van Genuchten (MvG) expression for both unimodal and bimodal soils was not able to predict the observed unsaturated K. Only a joint fitting of measured θ(h) and K(h) functions provided parameter estimates that were able to describe unsaturated K for uni‐ and bimodal soils. In addition, we observed a negative relationship between α and n in the case of low sand content (<52%) for both unimodal and bimodal matrix domain properties, contradicting the classical notion. The ratio of α for the macropore and matrix domain was positively correlated with the fraction of macropores and sand content. We anticipate that the results will contribute to deriving PTF for structured soils and avoid unrealistic combinations of MvG parameters.
The Common Good and the Anthropological Insight
Authors: Goodpaster Kenneth E. 
Published: September 2022

AbstractIn this chapter, I take up the insufficiency of the stockholder-stakeholder debate characteristic of business ethics in its earlier years. I argue that this debate rarely goes deeply enough: to a more comprehensive picture of the human person, a more robust account of the good. This is not optional—if such a more robust account of the good is not made explicit in a normative view of ethics, it inevitably enters beneath the surface, without being made explicit. The sources for more comprehensive accounts of the human person lie in moral traditions that we have inherited, faith traditions, or more secular rational frameworks. This realization, that a satisfactory account of applied normative ethics calls for an anthropology—a substantive view of the good for the human person and the common good of the human community—I call the anthropological insight. Without this insight, appeals to the interests of shareholders or stakeholders have very little content. Before concluding, this chapter explores two important topics: (a) the nature of the common good, and (b) the relevance of “mediating institutions.” Under (a), I discuss the aspiration of “integral human development” emphasized in several faith-based traditions. It maintains that if we focus on the good of the whole person, body and soul, including the reaching out for relationships that whole persons need for their flourishing, the good of all (the common good) can be achieved. Under (b), I argue that the common good requires mediating institutions between the individual and society at large: the family, churches, schools, voluntary organizations, businesses, and local governments. These institutions foster and reinforce the social motivations that are essential to the pursuit of the common good. This chapter is an organic part of a larger work about the overall contribution of Kenneth Goodpaster to the field of applied ethics and is best read in the context of that larger work.
Safety and short-term efficacy of preoperative FOLFOX therapy in patients with resectable esophageal squamous cell carcinoma who are ineligible for cisplatin
Authors: Kadono Toru , Yamamoto Shun , Hirose Toshiharu , Ikeda Go , Ohara Akihiro , Itoyama Mai , Yokoyama Kazuki , Honma Yoshitaka , Hashimoto Taiki , Sekine Shigeki , Ishiyama Koshiro , Oguma Junya , Daiko Hiroyuki , Kato Ken 
Published: September 2022

AbstractBackgroundThe standard preoperative treatment for resectable locally advanced esophageal squamous cell carcinoma (LAESCC) in Japan is docetaxel, cisplatin (CDDP), and 5-fluorouracil. However, patients with renal or cardiac dysfunction and elderly patients are ineligible for a CDDP-containing regimen because of toxicities. Oxaliplatin, leucovorin, and 5-fluorouracil (FOLFOX) therapy has less renal toxicity than CDDP-containing regimens and does not require hydration. However, there are limited data on preoperative FOLFOX therapy in these patients.MethodsThis retrospective study analyzed patients with resectable LAESCC who were aged ≥ 75 years or had renal or cardiac dysfunction and received preoperative FOLFOX between 2019 and 2021. FOLFOX was administered every 2 weeks for 3 or 4 cycles and was followed by surgery. Adverse events associated with chemotherapy, the complete resection (R0) rate, relative dose intensity (RDI), and histopathological response were evaluated.ResultsThirty-five patients were eligible. Median age was 77 (range 65–89) years; 68.6% were aged ≥ 75 years, 74.3% had renal dysfunction, and 17.1% had cardiac dysfunction. The RDI was 70.2% and 87.1% for bolus and continuous intravenous 5-fluorouracil, respectively and 85.2% for oxaliplatin. The most common grade ≥ 3 adverse events were neutropenia (60.0%) and leucopenia (28.6%). Two patients (5.7%) had febrile neutropenia and grade 3 pneumonia. Thirty-one patients underwent surgery. The R0 resection rate was 87.1%, and there was no histopathological evidence of residual tumor in 16.1%. There were no treatment-related deaths.ConclusionsPreoperative FOLFOX had a manageable safety profile and showed favorable short-term efficacy in patients with resectable LAESCC who were ineligible for CDDP-containing treatment.
Structural and mechanical anisotropy in rheotactically aligned bacterial cellulose
Authors: Gmach Yvonne , Opdenbosch Daniel Van 
Published: August 2022

AbstractIn this work, we demonstrate the preparation of oriented bacterial cellulose from Komagataeibacter sucrofermentans by rheotactic growth in a simple and adaptable setup. The resulting materials were assessed by their yields, geometric densities, and by X-ray diffraction, scanning electron and optical microscopy, and mechanical testing. They exhibited large differences in toughness, resulting from differences in fracture strain or highly anisotropic strengths. Their growth characteristics, structural and mechanical anisotropies and crystalline phase characteristics are discussed and compared to statically grown references and to instances from the literature. Here, we consider the length scales of structural anisotropy in native bacterial cellulose pellicles, and the origin of mechanical anisotropy. Further, we identify a tentative limit on achievable structural alignment in bacterial cellulose, as well as a correlation between crystallinity and disorder in the crystalline phase of bacterial cellulose.
The Associations between Child Irritability, Parental Distress, Parental Irritability and Family Functioning in Children Accessing Mental Health Services
Authors: Zendarski Nardia , Galligan Roslyn , Coghill David , Payne Jonathan M. , De Luca Cinzia R. , Mulraney Melissa 
Published: August 2022

AbstractIrritability, characterised by anger, frustration, and emotional dysregulation, is a common transdiagnostic symptom associated with child and adolescent referrals to mental health services and is associated with significant negative outcomes. Despite this, little is known about the link between irritability and the broader family environment. The present study described parental and family dysfunction in families of 51 children and adolescents (aged 6 to 15 years) with severe irritability referred to Victorian public mental health services. Further, we aimed to explore the associations between children’s irritability, parent functioning (parental distress and parental irritability), and family dysfunction. Child irritability was measured on the Affective Reactivity Index (ARI) and was obtained from participating children and their primary parent/caregiver (90% mothers). Participants psychiatric diagnoses were obtained using the Development and Well-Being Assessment through an interview with parents who also provided ratings of their own distress (Kessler 6), irritability (ARI), and family dysfunction (McMaster Family Assessment Device). We found high rates of family dysfunction (80%) and 39% of parents reported moderate to high psychological distress. Higher self-reported irritability was moderately associated with lower family dysfunction. All other relationships examined were non-significant. Findings suggest a complex relationship between severe childhood irritability and parental and family functioning with implications for treatment discussed.
Entrepreneurial ecosystems and industry knowledge: does the winning region take all?
Authors: Li Yating , Kenney Martin , Patton Donald , Song Abraham 
Published: September 2022

Abstract
Entrepreneurial ecosystems (EE) are composed not only of startups but also the organizations that support them. Theory has been ambivalent about whether an EE is spatially bounded or includes distant organizations. This exploratory study uses a time series of all Internet industry initial public offerings (IPO) to explore the locational changes not only of startups but also four key EE service providers: lawyers, investment bankers, venture capitalists, and board directors. We find that while the startups became only slightly more concentrated, the EE service providers concentrated more rapidly, as an industry center in Silicon Valley emerged. Our results suggest that over the industry life cycle, industry knowledge exhibits a tendency to spatially concentrate, and this results in a concentration of industry-specific EE service providers that is even greater than the more gradual concentration of startups. As a result, startups, wherever they are located, increasingly source EE services from the industrial knowledge concentration.