bluuebunny/crossref_metadata_2025_split huggingface dataset:
Influence of the ultra-fine fly ash dosages on the mechanical properties of the sulfoaluminate cement-based high water backfill material at different curing conditions
Authors: Sun Yaohui , Xie Shengrong , Wu Chaowen , Cui Junqi , Chen Dongdong , Guo Fangfang , Jiang Zaisheng , Ren Yuxin , Lu Weiyong 
Published: August 2022

Abstract
To reduce the filling cost of the high water backfill material (HWBM) in mining backfill and improve the recycling utilization of the industrial waste such as the coal fly ash. The ultra-fine fly ash (UFA) was added to the HWBM as a partial replacement in this work. Therefore, a series of experiments were performed to investigate the effect of UFA on the mechanic properties of the HWBM at the different curing conditions, then the hydration mechanism of the HWBM blended with UFA was analyzed by XRD and SEM method. The result indicates that the strength of the HWBM decreased with the dosages of UFA increasing, but the addition of UFA can improve the strength decreasing of the initial HWBM decreased at the ages of 28 days. Additionally, the addition of UFA have no obvious effect on the hydration products under the standard curing condition, while the later mechanical properties increased as the dosages of UFA were less than 15 % at the ages of 28 days. It indicates that the addition of UFA can improve the weathering resistance of the HWBM with the curing time increasing effectively.
Effects of supplement therapy on HBV-related HCC: a case report of a significant tumour regression
Authors: Lwin Khin Maung , Linn Ye Htut , Dee Yamin Kyaw Swar 
Published: August 2022

Abstract

Hepatocellular carcinoma (HCC) is a malignancy with a poor prognosis and is among the common causes of cancer-related deaths worldwide. The risk of HCC increases with several risk factors and co-factors. The well-known risk factors of HCC include cirrhosis, chronic hepatitis B virus infection (HBV), hepatitis C virus infection and metabolic liver disease. Many effective treatment modalities for HCC have been used in clinical treatment, such as hepatectomy, transhepatic arterial chemoembolization (TACE), radiofrequency ablation and chemotherapeutic agents. Herbal compounds could affect all phases of HCC, including initiation, promotion and progression. Therefore, herbal composite formula drugs are promising for preventing the invasion and proliferation of tumour cells. In this case report, we present a 71 years old Myanmar male patient with HCC with hepatitis B. Firstly, his hepatologists advised him to do TACE or liver resection. However, he did not agree with these treatment plans and decided to be treated with integrative medicines. He had been treated with tenofovir and herbal supplements such as milk thistle (silymarin), chamomile extract containing apigenin, luteolin, resveratrol, green tea extract containing epigallocatechin gallate, and lycopene. The patient is clinically stable with a reduction of AFP levels during follow-ups. After 6 months of treatment with integrative medicines, the AFP level reached normal, and there was no HCC on the CT scan 20 months after initiation of treatment. Moreover, the HBV DNA became undetected after 3 months of treatment. This case may provide helpful information for treating HCC with integrative medicine.
Non-destructive 3D pathology with analysis of nuclear features for prostate cancer risk assessment
Authors: Serafin Robert , Konyuncu Can , Xie Weisi , Huang Hongyi , Glaser Adam , Reder Nicholas , Janowczyk Andrew , True Lawrence , Madabhushi Anant , Liu Jonathan 
Published: August 2022

Abstract

Prostate cancer treatment decisions are heavily reliant upon the subjective visual interpretation (assigning Gleason patterns, or ISUP grade groups) of limited numbers of 2D histology sections. Under this paradigm, inter-observer variance is high, with ISUP grades not correlating well with the outcomes of individual patients, which contributes to the over- and under-treatment of patients. Recent studies have demonstrated improved prognostication of prostate cancer outcomes based on computational analyses of glands and nuclei within 2D whole slide images. Our group has also shown that the computational analysis of 3D glandular features, extracted from 3D pathology datasets of whole intact biopsies, can allow for improved recurrence prediction compared to corresponding 2D features. Here we seek to expand on these prior studies by exploring the prognostic value of 3D shape-based nuclear features in prostate cancer (e.g., nuclear size, sphericity). 3D pathology datasets were generated with open-top light-sheet (OTLS) microscopy of 102 cancer-containing biopsies extractedex vivofrom the prostatectomy specimens of n = 46 patients. A deep learning-based segmentation workflow for 3D nuclear segmentation and 3D glandular segmentation was used to segment nuclei within the glandular epithelium vs. stromal regions of the biopsies. 3D shape-based nuclear features were extracted, and a nested cross-validation scheme was used to train a supervised machine classifier based on 5-year biochemical recurrence (BCR) outcomes. Nuclear features of the glandular epithelium were found to be more prognostic than stromal cell nuclear features (AUC = 0.72 vs. 0.63). 3D shape-based nuclear features of the glandular epithelium were also more strongly associated with risk of BCR than analogous 2D features (AUC = 0.72 vs. 0.62). The results of this preliminary investigation suggest that 3D shape-based nuclear features are associated with prostate cancer aggressiveness and could be of value for the development of decision-support tools.
Efficient adsorptive removal of diclofenac sodium by acidified MIL101(Cr): optimizing the content of phosphotungstic acid (PTA), Flow loop thin film slurry flat plate reactor, Kinetic, thermodynamic and recycling studies
Authors: Sharifian Sina , Tabrizi Farshad Farshchi , Sardarian Ali Reza 
Published: August 2022

AbstractThe performance of Diclofenac sodium (DFs) adsorption by MIL101(Cr) and five different contents of PTA in PTA@MIL101(Cr) (encapsulated phosphotungstic acid (PTA) using one pot method) were investigated in a batch and a designed continuous flow loop thin film slurry flat plate reactor (TFSR). Excellent diclofenac sodium adsorption efficiency was achieved with 12 wt% PTA synthesized within the Metal Organic Framework (MOF) and using the Langmuir equation the maximum adsorption capacity of diclofenac sodium was 413.22 mg/g. The Langmuir model matched the isotherm adsorption data and the removal process was complemented with a pseudo–second–order kinetics model. According to the thermodynamic analyses, the process was found to be spontaneous and endothermic. In order to regenerate the MOF, 0.1 M HCl/EtOH (20/80 v/v) best performed as elution agent, regenerating the MOF to 88% of its originated maximum capacity after 5 times reusing. PTA (12 wt%) @MIL101 (Cr) showed to be a tremendous reusable adsorbent for removing DFs from aqueous media.
Incidence of traumatic sciatic nerve injury in patients with acetabular fractures and factors affecting recovery: a retrospective study
Authors: Liu Zhigang , Tao Fulin , Xu Weicheng , Liu Fanxiao , Dong Jinlei , Li Lianxin , Hao Zhenhai , Zhou Dongsheng , Lu Shun 
Published: August 2022

Abstract
Background
Reports on traumatic sciatic nerve injury associated with acetabular fracture are rare. In this study, we investigated the demographics of these injuries, their clinical characteristics, management, and factors potentially influencing neurological recovery.
Methods
We retrospectively reviewed all patients diagnosed to have acetabular fracture at our trauma center between January 2014 and June 2021. Data on patient demographics, characteristics of sciatic nerve injury, neurological recovery, factors potentially influencing neurological recovery were analyzed.
Results
Eighteen patients met the diagnostic criteria for acetabular fracture combined with sciatic nerve injury (bilateral in one case). All of these injuries involved the posterior wall or posterior column, and most patients had posterior dislocation of the hip joint. Four of the 19 sides with traumatic sciatic nerve injury involved the common peroneal nerve division and 15 involved both the common peroneal and tibial nerve divisions. The mean common peroneal and tibial nerve division injury scores were 1.79 ± 0.92 and 2.68 ± 1.57, respectively. Seventeen patients (18 sides) underwent intraoperative nerve exploration, which revealed abnormalities in 7 sides and no obvious abnormality in 11 sides. At the last follow-up, 10 sides (52.6%) had complete recovery and 9 (47.4%) had partial recovery; the difference was statistically significant between those with or without abnormal nerve damage during exploration (P < 0.05). Linear regression analysis showed that a nerve abnormality detected intraoperatively was a predictor of nerve recovery (P < 0.05). The degree of neurological recovery was not related to sex, age, cause of injury, type of fracture, hip dislocation, or femoral head injury in patients whether recovery was partial or complete. The mean recovery time was significantly longer for partial recovery than for complete recovery (13.78 months vs 6.70 months; P < 0.05).
Conclusions
All the injuries in this series involved the posterior wall or posterior column, and most patients had posterior dislocation of the hip joint. Damage to the common peroneal nerve division was more severe than that to the tibial nerve division preoperatively. However, the degree of recovery of the common peroneal division was not worse than that of the tibial division. There was a relationship between the degree of neurological recovery and whether there was an abnormality at the time of intraoperative nerve exploration. Patients with partial recovery took longer to recover.
In vitro and In vivo Hypoglycemic Effect of Wild Edible Termite Mushrooms
Authors: Parajuli Achut , Paudel Mukti Ram , Aryal Hari Prasad 
Published: August 2022

Abstract
Objective
Diabetes mellitus is characterized by the increase in glucose levels in the blood and serum because of a change in carbohydrates, fat and protein metabolism. Termite mushrooms are consumed for high nutrition and traditional medicine. The methanol extract of the four termite mushrooms; Termitomyces albuminosus, T. eurhizus, T. robustus and T. striatus f. ochraceus was tested for inhibition of alpha-amylase by the starch-iodine method, and effect on blood glucose level and body weight in alloxan-induced diabetic mice.
Results
The secondary metabolites in the methanol extract of termite mushrooms were screened. Alkaloid, flavonoid, polyose, steroid, glycoside, terpenoid, fatty acid and emodin were found in all the termite mushrooms. The extract of T. straitus f. ochraceus has shown a strong inhibition against porcine pancreatic alpha-amylase by 61.4% at 200 µg/ml concentration. The extracts of all termite mushrooms at 500 mg/kg showed a significant reduction in the blood glucose level after 15 days of administration. Extract of termite mushrooms in two doses (250 and 500 mg/kg) intraperitoneally administered to the alloxan-induced diabetic mice indicated a significant enhancement in their body weight as compared to diabetic mice. Hence, termite mushrooms can be used as a substitute supplement for the management of diabetes mellitus.
Real life experience following combined excimer laser trabeculostomy and phacoemulsification in eyes with ocular hypertension or mild glaucoma and cataract
Authors: Papa-Vettorazzi Renato , Pascual Laia , Moura-Coelho Nuno , Freixes Silvia , Arrondo Elena 
Published: August 2022

Abstract

PURPOSE: To assess the efficacy and safety of combined phacoemulsification and excimer laser trabeculostomy (ELT) in eyes with cataract and mild controlled glaucoma or ocular hypertension. METHODS: Single-centre analysis of eyes that underwent phacoemulsification and ELT between 2017 and 2021. Change in intraocular pressure (IOP), glaucoma medication requirements, corrected distance visual acuity (CDVA), complications and re-interventions were evaluated. Success was defined as a reduction ≥20% from preoperative IOP, an IOP ≤14 mmHg or a reduction in glaucoma medication requirements with an IOP equal or lower than the preoperative IOP.RESULTS: Mean follow-up was 658 ± 64 days. Mean preoperative IOP was 17.76 ± 4.88 mmHg, it decreased to 15.35 ± 3.10 mmHg at 1 year (n=37) (p = 0.006) and to 14.00 ± 3.78 at 3 years (n=8) (p = 0.074). Mean number of glaucoma medication requirements decreased from 2.02 ± 1.0 preoperatively to 1.02 ± 0.96 at 1 year (n=37) (p < 0.001) and to 1.63 ± 0.92 at 3 years (n=8) (p = 0.197). Complete success was achieved in 17.7% of eyes and qualified success in 54.8%. Two eyes of 2 patients had early postoperative hyphema. Two eyes of 1 patient underwent filtering surgery 2 months after the procedure, and 2 eyes of 1 patient underwent laser trabeculoplasty 3.8 years after the procedure due to uncontrolled IOP. CONCLUSIONS: Combined phacoemulsification and ELT is effective and safe in eyes with mild glaucoma or ocular hypertension and cataract. It significantly reduced IOP and glaucoma medication requirements 1 year after surgery.
Deep Counterfactual-Guided MRI Feature Representation and Quantitatively Interpretable Alzheimer’s Disease Prediction
Authors: Oh Kwanseok , Heo Da-Woon , Mulyadi Ahmad Wisnu , Jung Wonsik , Kang Eunsong , Lee Kun Ho , Suk Heung-Il 
Published: August 2022

Abstract
Deep learning for Alzheimer's disease (AD) prediction has provided timely prevention of disease progression yet still demands attentive interpretability. Recently, counterfactual reasoning has increasingly been exploited in medical research by providing refined visual explanatory maps. However, such visual explanatory maps alone are not self-sufficient unless we can intuitively demonstrate their validity via quantitative features. For this, we first synthesize the counterfactual-labeled structural MRI using our proposed framework. We further transform it as a gray matter density map to precisely measure its volumetric changes over the parcellated region of interests (ROIs). Furthermore, to boost the effectiveness of selected ROIs while promoting interpretability and achieving comparable predictive performance to deep learning methods, we devise a novel lightweight counterfactual-guided attentive feature representation constructed to a linear classifier. Thus, our framework provides an AD-relatedness index for each ROI, offering an intuitive understanding of brain status for an individual subject and across subjects regarding AD.
Relationship between climate and land use land cover change over West Africa
Authors: MORTEY Eric Mensah , ANNOR Thompson , ARNAULT Joël , INOUSSA Maman Maarouhi , MADOUGOU Saïdou , KUNSTMANN Harald , NYANTAKYI Emmanuel Kwesi 
Published: August 2022

Abstract

The relationship between climate and land use land cover change over West Africa has often been assessed with climate simulations, although the model-based approach suffers from the limitations of climate models specifically for West Africa. In this paper, an alternative approach based on physical analysis of historical land cover data and standardized climatic indices is used to investigate climate-land interactions to establish the climatic thresholds and their corresponding land use impacts. Annualized land change intensities and the climatic indices are first estimated separately and then linked at various spatiotemporal scales. The result shows that climate-induced land cover change results from abrupt changes in climatic conditions. A regional change of (-1.0–1.0)\(℃\), (0–1.5)\(℃\),(-0.5–0.5)\(℃\), and up to \(\pm\)50 mm changes in precipitation and climatic water balance leads to (45039–52133) km2, (20935–22127) km2 and approximately 32000 km2 changes respectively, while a \(\pm\)0.5\(℃\) and \(\pm\)20 mm change represents normal climate conditions with changes below 20000 km2. Conversely, the plausible pathways through which West African land surface impacts the climate is the conversion of cropland, forest, grassland, and shrubland. The average climatic risk ranges from − 0.025 to 0.025 yr−1 while the probability of occurrence ranged variably from 0 to 0.833. The results offer the basis to re-evaluate land and climatic information necessary for improving the reliability of climate models over West Africa. For sustainable development, this work reveals the need for policy-driven interventions for efficient resource management and the prevention of degradation and deforestation in the region.
Beneficial effects of curcumin in the diabetic rat ovary: A stereological and biochemical study
Authors: Tüfekci Kıymet Kübra , Kaplan Suleyman 
Published: August 2022

Abstract

Study investigated the effects of curcumin treatment on diabetic ovaries at different periods of the disease. Fifty-six female Wistar albino rats (250–300 g) aged 12 weeks were divided into seven groups. No treatment was applied to the control group. The sham group was given 5 mL/kg of corn oil, and the curcumin group 30 mg/kg curcumin. In the DM groups, diabetes was induced by a single intraperitoneal dose of 50 mg/kg streptozotocin (STZ). The DM-treated groups received 30 mg/kg curcumin after either seven days (DC1 group), or 21 days (DC2 group), or simultaneously with STZ injection (DC3 group). Numbers of follicles in the ovaries were estimated using stereological method. FSH, LH, and SOD levels and CAT activity were measured in serum specimens. Follicle numbers and volumes of corpus luteum, blood vessel and cortex volumes, gonadosomatic index, and FSH and SOD levels all decreased significantly in diabetic ovaries, while relative weight loss, connective tissue volume, and CAT activity increased (p < 0.01). Curcumin treatment had a protective effect on the number of primordial follicles in the DC2 group and on antral follicle numbers in the DC3 group. Curcumin also exhibited positive effects on CAT activity and SOD levels, blood glucose levels, and corpus luteum, connective tissue and blood vessel volumes in the DC2 and DC3 groups. Curcumin also ameliorated FSH levels in the DC1 and DC3 groups (p < 0.01). Curcumin exhibits protective effects on ovarian structures and folliculogenesis, especially when used concurrently with the development of diabetes or in later stages of the disease.
Calcium induces death is associated with Pyroptosis and the anti-tumor immunity in breast cancer
Authors: Wei Zhao , Chunxiang Lin , Kexuan Wei , Liuli Chen , Qiulu Song , Huaying Zhang 
Published: August 2022

Abstract
Background: Calcium (Ca2+) binds to the intracellular receptor calmodulin (CALM) as an intracellular messenger， Activates multiple downstream signalling pathways. In addition, previous studies report that the Ca2+/CAMK（calcium/calmodulin-dependent protein kinase） family plays an essential part in metabolic homeostasis. However, few studies have systematically analyzed the parts of the CALM and CAMK families in cancer. Therefore, CALMs/CAMKs were examined to determine their molecular characteristics and potential clinical significance in pan-cancer and to validate the connection between CAMK4 and pyroptosis of breast cancer cells.Methods: We downloaded the data from public databases, including cBioPortal for Cancer Genomics, GSCALite tool, UALCAN databases and Human Protein Atlas (HPA). Based on the Kaplan-Meier plotter platform, bc-GenExMiner and R 4.2.0, DRUGSURV database, prognosis in BRCA was analyzed. Individual CAMK4 and Pyroptosis related genes were respectively enriched on different pathways and biological processes via the GeneMANIA. Additionally, based on the TIMER, UCSC Xena, and TISIDB databases, we evaluated the relationship between CAMK4 and the immune microenvironment. GSCALite tool and CMap database were applied to predict small molecule compounds. Results: The different expression patterns of CALMs and CALMKs may be related to the different frequencies of genetic mutations, and these genes were involved in tumorigenesis pathways, which were closely connected to the prognosis of breast cancer. Furthermore， upregulation of CAMK4 expression correlated with progression of the tumor for patients with BRCA. CAMK4 and PRGs were connected with the tumor immune infiltration status of BRCA, which co-enriched genes can predict small molecule compounds for breast cancer treatment, such as ELAVL1, fasudil, ADC, PTPN1, etc.Conclusions: In breast cancer, the prolonged prognosis caused by upregulation of CAMK4 expression was assessed to be due to high immune infiltration. CAMK4 and PRGs co-regulate the tumor immune infiltration status of BRCA, which can be used as an intervention target for breast cancer anti-tumor immunotherapy.
Photonic System for Real Time Detection, Discrimination, and Quantification of Microbes in Air
Authors: Tatavarti Rao , Nadimpalli Sridevi , Mangina Gowtham Venkata Kumar , Machiraju Naga Kiran , Pachiyappan Arulmozhivarman , Hiremath Shridhar , Jagannathan Venkataseshan , Viswanathan Pragasam 
Published: August 2022

Abstract
This article reports the successful results from the recently developed non-invasive photonic system AUM - for real time, discrimination and quantification of different pathogenic bacterial strains, and mixtures of bacterial species in air. The uniqueness and novelty of the AUM photonic system, lies in its ability to innovatively apply the concepts of elastic light scattering, statistical mechanics, artificial intelligence, and machine learning to identify, classify and quantify various microbes present in the scattering volume in real time; and therefore, can become a potential tool in the control and management of diseases caused by pathogenic microbes.
Biological proof of a hit-and-run tumour formation in oropharyngeal cancers
Authors: Ferreira Danyelle , Idris Adi , McMillan Nigel 
Published: August 2022

Abstract
It has long been wondered if viruses cause cancer via a “hit-and-run” mechanism. We examined this in HPV-driven oropharyngeal cancer (OPC) using CRISPR to delete the viral oncogene, E7. Tumours regressed yet regrew over 3 months, despite the lack of E7, and had formed new mutations commonly found in HPV- OPC patient tumours. This is the first biological proof that HPV- OPCs can be formed via a hit-and-run HPV infection.
Mapping of Digital Health Interventions to address latent Tuberculosis Infection: A Scoping Review protocol
Authors: Kumar Rohitashwa , Kumar Devendra , Joshi Ashish , Verma Ashwani , Bharath CNV Sai , Islam KM Monirul 
Published: August 2022

Abstract
Introduction:
Globally, TB is one of the top 10 causes of mortality due to a single infectious agent “Mycobacterium Tuberculosis”, responsible for more than 10 million global infections each year and it is estimated that around 170 million people’s LTBI will develop active TB in future. Digital health interventions are gradually being integrated into TB care and are tested and evaluated in trials focused specifically on TB and very few on LTBI care. This review outlines the globally published literature on digital health interventions implemented to address LTBI and to describe various components of digital health interventions.
Methods
Arksey and O’Malley’s scoping review methodological framework will be followed to conduct this review. Searches will be conducted in five databases and hand search of references studies included. Two independent reviewers will be conducting title and abstract screening followed by full-text screening, data extraction, and quality appraisal. Results will be summarized to generate findings of the digital health interventions to address LTBI and reported in a tabular format and narrative synthesis conducted.
Conclusion
This review will be beneficial for synthesizing evidence of the role of digital health interventions, opportunities and challenges to address LTBI care and facilitate decision-making across diverse stakeholders such as clients, health care providers, health systems or resource managers, and data services. This scoping review will inform researchers, policy makers, and decision makers to design, develop and expand the use of an innovative and evidence based digital health technology intervention for improved LTBI care.