bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ion imprinted sodium alginate hydrogel beads enhanced with carboxymethyl cellulose and β-cyclodextrin to improve adsorption for Cu2+
Authors: Fan Yajun , Shen Dianling , Yan Yu , Hu Xiaopeng , Guo Yaping , Zhong Yujun , Li Zhiyang , Xie Lianwu 
Published: March 2022

Abstract
Using Cu2+ as template ion, three sodium alginate hydrogel beads including SA, SAC, and SAB beads were prepared with sodium alginate blending with different precursors of carboxymethyl cellulose and β-cyclodextrin, respectively. The effect of pH, adsorption time, initial concentration of Cu2+, adsorbent dosage, and coexisting ions on the adsorption efficiency of three hydrogel beads was investigated. The results indicated that adding carboxymethyl cellulose and β-cyclodextrin into skeleton of beads increased the toughness of the beads and improved the adsorption capacity of Cu2+. The adsorption rate of Cu2+ on SA beads was conformed to the pseudo-first order kinetic equation, while the adsorption behavior of Cu2+ on SAC or SAB beads could be confirmed to the pseudo-second-order kinetic equation. Compared with the saturated adsorption capacity 510 mg/g of Cu2+ on SA, the saturated adsorption capacity of Cu2+ on SAB and SAC reached 817 mg/g and 822 mg/g, respectively, with their Cu2+ adsorption efficiency over 95% at 25°C. Thus, SAC and SAB beads could be used as adsorption material for detecting and removing Cu2+ from wastewater.
Severe Neuro-COVID is associated with peripheral immune signatures, autoimmunity and neurodegeneration: a prospective cross-sectional study
Authors: Etter Manina , Martins Tomás , Kulsvehagen Laila , Pössnecker Elisabeth , Duchemin Wandrille , Hogan Sabrina , Sanabria-Diaz Gretel , Müller Jannis , Chiappini Alessio , Rychen Jonathan , Eberhard Noëmi , Guzman Raphael , MarianI Luigi , Keller Emanuela , Melie-Garcia Lester , Jelcic Ilijas , Pargger Hans , Siegemund Martin , Kuhle Jens , Oechtering Johanna , Eich Caroline , Tzankov Alexandar , Matter Matthias , Yaldizli Özgür , Lieb Johanna , Psychogios Marios , Berkemeier Caroline , Leuzinger Karoline , Hirsch Hans , Granziera Cristina , Pröbstel Anne-Katrin , Hutter Gregor 
Published: March 2022

Abstract
Growing evidence suggests that coronavirus disease 2019 (COVID-19) is associated with acute and long-term neurological sequelae. However, the underlying pathophysiological mechanisms resulting in central nervous system (CNS) derogation remain unclear, posing both diagnostic and therapeutic challenges. Here, we performed a cross-sectional study (NCT04472013) and multidimensional characterization of cerebrospinal fluid (CSF) and plasma-targeted proteomics in different Neuro-COVID severity classes with corresponding clinical and imaging data. COVID-19 patients displayed a plasma cytokine storm but a non-inflammatory CSF profile. Severely affected patients displayed signs of blood-brain barrier (BBB) impairment, elevated microglia activation markers and a polyclonal B cell response targeting self- and non-self antigens. Also, COVID-19 patients had decreased regional brain volumes associated with specific CSF and plasma parameters. We provide a multiparametric framework of Neuro-COVID severity classifiers. Collectively, this data identified several potentially actionable targets that may be addressed to prevent COVID-19-related neurological sequelae.
Postoperative Outcomes Of Minimally Invasive Adrenalectomy - Do Body Mass Index And Tumor Size Matter? A Single Center Experience
Authors: Giron Felipe , Rey Carlos , Rodriguez Lina , Conde Danny , Vanegas Marco , Toledo Sara , Nassar Ricardo M 
Published: March 2022

Abstract
Background: Since Gagner performed the first laparoscopic adrenalectomy in 1992, laparoscopy has become the gold-standard procedure in the treatment of adrenal surgical diseases. Literature indicates that the rate of intra- and postoperative complications are not negligible. This study aims to describe the single-center experience of adrenalectomies; and explore the associations between body mass index (BMI) and tumor volume in main postoperative outcomes. Methods: Retrospective observational study with a prospective database in which we described patients who underwent adrenalectomy between January 2015 and December 2020. Operative time, intraoperative blood loss, conversion rate, complications, length of hospital stay, and comparison of the number of antihypertensive drugs used before and after surgery were analyzed. Analysis of BMI and tumor volume with postoperative outcomes such as anti-hypertensive change (AHC) in drug usage and pre-operative conditions were performed. Results: 45 adrenalectomies were performed, all of them were carried out laparoscopically. 4 were performed as a robot-assisted laparoscopy approach. 19 were women and 26 were men. Mean age was 54.9 ± 13.8 years. The mean tumor volume was 95.698 mm3 (Range 3.75 - 1010.87). Mean operative time was shorter in right tumors (2.64 ± 0.75 hours ) than in left tumors (3.33 ± 2.73 hours). Pearson correlation was performed to assess the relationship between BMI and AHC showing a direct relationship between increased BMI and anti-hypertensive drugs usage decrease r(45)= 0.92, p > 0.05 CI 95%. Operative time, Higher tumor volume showed a longer operative time, r(45)=0.6 (p=0.000 CI 95%). Conclusions: Minimally invasive adrenalectomy appears to have an increased impact in patients with higher BMI in terms of postoperative anti-hypertensive usage. Tumor volume seems to be associated with higher operative time and blood loss leading possibly to increased rates of morbidity. Nevertheless, due to our limited number of patients, more studies are needed to replicate and validate these results.
The Effect of Tohoku Earthquake on Japan’s Bilateral Trade Distribution: Case Study of African Markets
Authors: BIYIK Onur 
Published: March 2022

Abstract
This paper examines the Japanese International Bilateral Trade Flow (JIBTF) in relation to the economic crisis, such as the Tohoku earthquake, and focuses on changes in the Distribution Networks of JIBTF (DNoJ) concerning African countries and Japanese Major Trade Partners (JMTP). The Harmonized System 6-digit level (“total” and product level) panel data from 2001 to 2019 are analyzed by employing the (structural) gravity method. The results of the study find that the Tohoku earthquake affects the DNoJ among Japanese trade partners. Specifically, Japanese trade intention with African markets decreases relatively. In other words, exporting to African countries has a negative interaction effect after 2015. On the contrary, this interaction effect on JMTP comparatively increases; thus, Japan relocates its export to other markets such as JMTP. The Tohoku earthquake shaped the JIBTF to be more integrated with the Asia-Pacific and the EU regions, instead of African markets.
A highly sensitive and versatile fluorescent biosensor for pathogen nucleic acid detection based on toehold-mediated strand displacement initiated primer exchange reaction
Authors: Zhang Ye , Li Zihua , Su Wanting , Zhong Guangzhi , Zhang Xiaohe , Wu Yuan , Situ Bo , Xiao Yunju , Yan Xiaohui H , Zheng Lei 
Published: March 2022

Abstract
Existing methods for pathogen nucleic acid detection, such as PCR, require complicated operation and expensive facility. Here, we report a simple and versatile strategy for highly sensitive detection of pathogen nucleic acid based on toehold-mediated strand displacement initiated primer exchange amplification (t-PER). In the presence of target, the blocked hairpin substrate would be released by toehold-mediated strand displacement, which triggered the primer exchange reaction amplification. Then, multiple long tandem-repeat single-strands generated by PER could open the molecular beacon to recover the fluorescence signal. Based on the target selection and conditions optimization, the developed platform could detect down to 18 fM of target in 1 hour of process time with high discrimination factor. It is also successful applied for direct detection of HPV from clinical cervical swab samples, the results were consistent with those obtained from RT-PCR. Moreover, the versatility and clinical feasibility of this method was further confirmed by measuring Epstein-Barr virus, Hepatitis B virus, and Ureaplasma Urealyticum from different clinical samples (serum samples and urine samples). This simple platform enables specific and sensitive detection of pathogen nucleic acid in a format that might hold great potential for point-of-care infection diagnosis.
Rubus idaeus extract improves symptoms in knee osteoarthritis patients: results from a double blind randomized clinical trial
Authors: Henrotin Yves , Cozannet Romain Le , Fança-Berthon Pascale , Truillet Romain , Cohen-Solhal Martine , DunnGalvin Gillian , Grouin Jean-Marie , Doolan Andrea 
Published: March 2022

Abstract
BackgroundOsteoarthritis (OA) is the most frequent cause of disability in elderly people. In daily practice, the main objective of the physician is to reduce patient symptoms using treatments without adverse effects. However, the most prescribed treatment to manage OA symptoms remains nonsteroidal anti-inflammatory drugs which are associated with severe adverse effects. Therefore, we need a safe alternative to managing OA. One candidate is Rubus idaeus leaf extracts known to inhibit inflammatory responses.ObjectiveThis study aimed to investigate the effects of a 12-weeks intervention with an ethanolic extract from Rubus idaeus leaf on symptoms of knee osteoarthritis.MethodThe study was a randomized, double-blind, placebo-controlled, monocentric trial of 198 participants with femorotibial osteoarthritis. Participants were randomized equally to receive one daily during 3 months either 1 capsule of Rubus idaeus leaf extract 400 mg, 1 capsule of Rubus idaeus leaf extract 200 mg, or 1 capsule of placebo. The primary endpoint was an absolute change of the Western Ontario McMaster osteoarthritis index (WOMAC) pain subscale. The secondary endpoints were WOMAC global score, stiffness and function sub-scales, knee pain VAS score at walking, the Short Form (SF)-36, the Short Physical Performance Battery (SPPB), the 20-meter walk test, and the International Physical Activity Questionnaire (IPAQ) and Outcome Measures in Rheumatology Clinical Trials and Osteoarthritis Research Society International (OMERACT-OARSI) responders rate.ResultsIn the ITT population, WOMAC pain was not significantly modified by Rubus idaeus leaf extract compared to placebo. In contrast, Rubus idaeus leaf extract 400 mg after 12 weeks of treatment significantly reduced pain measured by the VAS. The mean pain decrease induced by Rubus ideaus leaf extract was over − 7 mm which is clinically relevant and reached clinically statistical difference compared to placebo with the highest dose.ConclusionRubus idaeus leaf extract was well tolerated and effective to relieve pain in a patient with knee osteoarthritis.Trial registration: NCT03703024 https://clinicaltrials.gov/ct2/show/NCT03703024 (11/10/2018).
Research through action: research protocol on the implementation of an integrated place-based primary intervention in a multicultural context.
Authors: Maillet Lara , Manceau Luiza Maria , Desjardins France , Gagnon Suzanne , Naraziah Lavanyah , Malham Sabina Abou 
Published: March 2022

Abstract
Our project specifically aims at improving the adaptation capacity of primary services to answer the complex needs of vulnerable people. The aim is to co-build, with our collaborators and partners, environment-based strategies enabling the coordination of primary services offered by health, social and community responders all the while ensuring the continuity of care (informational, relational, and contact) of vulnerable people, especially refugees. A particular attention is brought toward the experiential knowledge of the health system users. Therefore at least three citizen-partners are part of the research team since the beginning of the project.Goals: This research-action aims at implementing a “meshing innovation”, meaning an intervention that is integrated, lasting, and based on the needs of a community located in a Sherbrooke neighbourhood in order to improve the care of refugee people in a continuum of primary services. To reach this goal, we have 5 specific objectives. The overall goal of this project is to improve the services trajectory in the health and social services network for refugee people in Quebec. The implementation of a meshing innovation, through this pilot project, is a first step toward this overall goal. Method: This project falls within a participative research approach, based on the symmetry principle of the researchers and field stakeholders’ knowledge. To do so, we choose three distinct sources of data: (1) literature review, (2) focus group (N=9 twice), and (3) semi-structured interviews (N=10).Expected results: Concretely, an Implementation guide of establishment strategies for integrated interventions enabling the improvement of primary care for refugees will be written and will constitute the basis for an appropriation workshop for the members of the two joint research networks focused on primary practices (RRAPPL) (Université de Laval and Université de Sherbrooke) and, eventually, in other fields interested in adapting and implementing these strategies. In addition to this guide, we wish to facilitate the care of refugees by family practitioners of the territory; therefore, many of them are part of the project. Explicit ties will help raising awareness toward other family practitioners working in medical clinics of the territory while trying to facilitate a specific attribution to these practitioners through the Quebec Family Doctor Finder (GAMF). With this project, we strongly hope to promote the vulnerability factors of refugees to the Health and Social Services Department (MSSS) and to the Quebec General Practitioners Federation (FMOQ) to change the priority at the GAMF. Finally, a scientific publication will be written for an international journal.
Summary and Analysis of 13 RAS-Associated Autoimmune Leukoproliferative Disease Clinical Features
Authors: FU lingling , Ma Jie , Yao JiaFeng , Jiang Jin , Wei Yunyun , Yang Bixi , Wang Ruixin , Li Hongmin , Wu Runhui 
Published: March 2022

Abstract
Ras-associated autoimmune leukoproliferative disease (RALD) is a clinical syndrome, also known as autoimmune lymphoproliferative syndrome (ALPS) type IV, which is a primary immunodeficiency disease. However, there is still controversy about whether RALD is a chronic benign lymphoproliferative disease or a precancerous lesion. The clinical characteristics, laboratory examination results, treatment and prognosis of children with RALD treated in Beijing Children's Hospital were analyzed retrospectively. We reported 13 patients with RALD in our single center. The male-to-female ratio was 1.6:1, and the median age of onset was 6 months (range 2 months- 29 months). Eight patients (61.5%) had KRAS somatic mutations, and five patients (38.5%) had NRAS somatic mutations. The most common features were splenomegaly (12/13 cases), autoimmune cytopenia (9/13 cases), mononucleosis (10/13 cases), recurrent infection (7/13 cases), skin involvement (4/13 cases) and intestinal lesions (4/13 cases). Thirteen children were treated with immunotherapy, including glucocorticoids, intravenous immunoglobulin, cyclosporine, and sirolimus. The median follow-up time was 50 months (range 3 months-62 months). Four children died (2 cases of respiratory failure, 1 case of intestinal perforation and bleeding, and 1 case of sepsis with sudden respiratory and cardiac arrest). Nine children survived, seven children were treated with sirolimus, and no children developed malignant tumors of the hematopoietic system. In conclusion, RALD requires long-term follow-up to monitor malignant tumors, and sirolimus is effective for treatment.
Characterizing Disparities in Risky Alcohol Use, Tobacco Smoking, E-Cigarette Use and Physical Inactivity Among Cancer Survivors in the United States
Authors: Kim Jiyeong , Keegan Theresa H 
Published: March 2022

Abstract
Purpose.
Unhealthy lifestyle behaviors are associated with inferior health outcomes among cancer survivors, including increased mortality. It is crucial to identify vulnerable subgroups, yet investigations have been limited. Thus, this study aimed to examine sociodemographic and clinical characteristics associated with risky health behaviors among cancer survivors.
Methods.
We used national survey data (Health Information National Trends Survey, HINTS 2017–2020) for 2,579 cancer survivors. We calculated the prevalence of risky alcohol use, current tobacco smoking, e-cigarette use, and not meeting physical activity guidelines. We performed weighted logistic regression to obtain multivariable-adjusted odds ratios (OR) for the association between each unhealthy behavior with sociodemographic and clinical characteristics.
Results.
Overall, 25% showed risky alcohol use, 12% were current tobacco smokers, 3% were current e-cigarette users, and 68% did not meet physical activity guidelines. Cancer survivors who were males, non-Hispanic Whites or African Americans, without a college education, not married, with comorbidities or psychological distress were more likely to have unhealthy behaviors. Those with lung disease or depression were 2 times more likely to smoke tobacco or e-cigarettes and those with psychological distress were more 1.6 times more likely to be physically inactive. Moreover, risky drinkers (OR = 1.75, 95% CI = 1.22–2.52) and e-cigarette smokers (OR = 16.40, 95% CI 3.29–81.89) were more likely to be current tobacco smokers.
Conclusions
. We identified vulnerable subpopulations of cancer survivors with multiple unhealthy lifestyle behaviors.
Implications for Cancer Survivors
. Our findings inform clinicians and program and policy makers of the subgroups of cancer survivors to target for multiple health behavior interventions.
Discovery of Potential Compounds Against Nipah Virus: A Molecular Docking and Dynamics Simulation Approaches
Authors: Bhuiyan Maruf Ahmed , Keya Nawshin Atia , Mou Farha Susan , Imon Raihan Rahman , Alam Rahat , Samad Abdus , Ahammad Foysal 
Published: March 2022

Abstract
Nipah virus (NiV) is a zoonotic pathogen that causes Nipah encephalitis. it was thought to have transmitted from bats to pigs and ultimately to humans. Infected humans may experience an asymptomatic infection or mild to deadly symptoms. The coordinated actions of envelope attachment glycoprotein led to viral entry. NiV has been classified as a pandemic potential virus due to the lack of specialized vaccinations or treatments, as well as its high pathogenicity. In Computer-Aided Drugs Design study, active site prediction, ADMET properties, molecular docking assist to select five suitable small molecular compounds including control compound against NiV attachment glycoprotein(G) chain A to suppress its function. Binding affinity scores of selected compounds were distributed between -6.2 to -6.5 kcal/mol. All the selected compounds had desirable non-toxic and good pharmacokinetics properties. In Molecular Dynamic (MD) simulation, the ligands Amb33921182, Amb35795905, Amb22736116, and Amb28974637 are all potential drug candidates, but Amb33921182 is the most acceptable. This in-silico method has the potential to help with drug discovery and development in a short period of time against Nipah virus.
Infodemiology of autoimmune encephalitis: An analysis of online search behavior using Google Trends
Authors: Roberto Katrina Torres , Jamora Roland Dominic G. , Moalong Kevin Michael C. , Espiritu Adrian I. 
Published: March 2022

Abstract
BackgroundPatients and their caregivers, including clinicians and educators, use web-based search engines to access healthcare-related information from the internet. Online search behavior analysis has been used to obtain insights on health information demand.ObjectivesWe aimed to describe the online search behavior for autoimmune encephalitis worldwide over time through the analysis of search volumes made on Google.MethodsIn this infodemiological study, we retrieved search volume indices for the keyword “autoimmune encephalitis (disease)” based on worldwide search data from January 01, 2004 to October 31, 2021, using Google Trends. We performed a descriptive analysis of search volume patterns, including related topics and queries.ResultsThere was a progressive increase in search volume numbers over time for the keyword “autoimmune encephalitis (disease)” with no annual seasonal variation. Peak search volume was recorded in July 2018. The greatest search volume was recorded in Singapore, followed by Australia, the United States of America, the Philippines, and New Zealand. The most searched topics were related to autoimmune encephalitis definition, causes, symptoms, diagnosis, and treatment. All related topics and queries increased in volume by more than 5000-fold over time.ConclusionsThis study showed an uptrend in the online search interest on autoimmune encephalitis over time, which may reflect the increased awareness on the condition by the public and the medical community. Information on online health information-seeking behavior may be obtained from Google Trends data despite its limitations.
An investigation into mental distress among students at Universities in the Eastern Cape, South Africa
Authors: Mutinta Given 
Published: March 2022

Abstract
IntroductionMental distress is a global health concern. Studies show that the prevalence of mental distress is higher in students’ population than in the general population. Therefore, there is need to understand the extent and predictors of mental distress among students to help policymakers and practitioners in South Africa. Aim of the studyTh­e study was designed to investigate into the prevalence and predictors of mental distress among students at universities in the Eastern Cape Province, South Africa. MethodsA cross-sectional research design and quantitative research method guided this study. The data were collected from 844 students from four universities in the Eastern Cape Province using an online self-reporting questionnaire-20 to assess mental distress of students. Multivariable logistic regression modelling determined the association between socio-demographic and psychosocial factors with students’ mental distress.Findings The prevalence of mental distress among students was 53.3% (95% CI: 47.0%, 58.1%). Female students were more prone to mental distress than male students ([AOR]: 4.67; 95% CI: 2.82, 7.72). Poor sleep quality (AOR: 2.24; 95% CI: 1.13, 3.67) and using cannabis (AOR: 3.10; 95% CI: 1.755, 5.51) were significantly correlated with students’ mental distress.Conclusion and recommendations The study found the level of mental distress to be higher among students than what is reported in most of the previous studies in South Africa. Being a female student, a user of cannabis, and having poor sleep quality were predictors of mental distress. Findings point to the need to devise evidence-driven interventions and strategies to prevent and reduce the problem of mental distress among students.