bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of climate change on the elevational and latitudinal distributions of populations of Tipulidae (Diptera) in Wales, United Kingdom
Authors: Devlin Jack J , Thomas Robert J , Long Sarah E , Boardman Pete , Dupuis Julian R 
Published: July 2022

Abstract
As dominant features of most ecosystems, insects are responsive to changes in climate, both over short temporal scales (e.g. seasonal fluctuations in abundance) and over longer evolutionary scales (e.g. decade-scale changes in patterns of biodiversity). One such taxonomic group that is sensitive to changing climate are the craneflies (Diptera: Tipulidae). Here, we used aggregated biodiversity data to examine elevational and latitudinal distributions of adult Tipulidae between 1976 and 2019 in Wales, UK, and we related these distributions to climatic patterns. Our analyses showed that species with earlier-emerging adults were most affected by weather conditions in the year before observation. Specifically, as temperature increased, observed elevation increased in high-precipitation conditions, remained stable in average-precipitation conditions and decreased in low-precipitation conditions. For species with later-emerging adults, associations were seen between elevation and weather conditions in the year of observation. Observed latitude generally exhibited a negative association with maximum temperature in the year before observation, with observations of Tipulidae trending southwards during the 43-year study period. Our results support consideration of emergence phenology, weather and habitat data when predicting species distributional changes attributable to climate change, which is vital in understanding the selection pressures that species face in a changing environment.
Rising from the Ashes: The Biogeographic Origins of Modern Coral Reef Fishes
Authors: Cantalice Kleyton M , Alvarado-Ortega Jesús , Bellwood David R , Siqueira Alexandre C 
Published: July 2022

Abstract
During the excavation of Mayan tombs, little did the archaeologists know that the fossils they discovered in the tomb stones would fundamentally alter our understanding of the earliest origins of coral reef fishes. Located just 500 kilometers from the point where an asteroid impact reconfigured the world's biological systems 66 million years ago, we find the earliest origins of three typical reef fish groups. Their presence in Mexico just 3 million years after this impact finally reconciles the conflict between the fossil and phylogenetic evidence for the earliest origins of reef fishes. The incorporation of these fossils into a global reconstruction of fish evolutionary history reveals a new picture of the early biogeography of reef fishes, with strong Atlantic links. From locations associated with biological destruction and societal collapse, we see evidence of the origins of one of the world's most diverse and spectacular marine ecosystems: coral reefs.
Multi-method investigation of factors influencing amyloid onset and impairment in three cohorts
Authors: Betthauser Tobey J , Bilgel Murat , Koscik Rebecca L , Jedynak Bruno M , An Yang , Kellett Kristina A , Moghekar Abhay , Jonaitis Erin M , Stone Charles K , Engelman Corinne D , Asthana Sanjay , Christian Bradley T , Wong Dean F , Albert Marilyn , Resnick Susan M , Johnson Sterling C ,   Alzheimer’s Disease Neuroimaging Initiative
Published: July 2022

Abstract
Alzheimer’s disease biomarkers are becoming increasingly important for characterizing the longitudinal course of disease, predicting the timing of clinical and cognitive symptoms, and for recruitment and treatment monitoring in clinical trials. In this work, we develop and evaluate three methods for modelling the longitudinal course of amyloid accumulation in three cohorts using amyloid PET imaging. We then use these novel approaches to investigate factors that influence the timing of amyloid onset and the timing from amyloid onset to impairment onset in the Alzheimer's disease continuum.
Data were acquired from the Alzheimer's Disease Neuroimaging Initiative (ADNI), the Baltimore Longitudinal Study of Aging (BLSA) and the Wisconsin Registry for Alzheimer's Prevention (WRAP). Amyloid PET was used to assess global amyloid burden. Three methods were evaluated for modelling amyloid accumulation using 10-fold cross-validation and holdout validation where applicable. Estimated amyloid onset age was compared across all three modelling methods and cohorts. Cox regression and accelerated failure time models were used to investigate whether sex, apolipoprotein E genotype and e4 carriage were associated with amyloid onset age in all cohorts. Cox regression was used to investigate whether apolipoprotein E (e4 carriage and e3e3, e3e4, e4e4 genotypes), sex or age of amyloid onset were associated with the time from amyloid onset to impairment onset (global clinical dementia rating ≥1) in a subset of 595 ADNI participants that were not impaired before amyloid onset.
Model prediction and estimated amyloid onset age were similar across all three amyloid modelling methods. Sex and apolipoprotein E e4 carriage were not associated with PET-measured amyloid accumulation rates. Apolipoprotein E genotype and e4 carriage, but not sex, were associated with amyloid onset age such that e4 carriers became amyloid positive at an earlier age compared to non-carriers, and greater e4 dosage was associated with an earlier amyloid onset age. In the ADNI, e4 carriage, being female and a later amyloid onset age were all associated with a shorter time from amyloid onset to impairment onset. The risk of impairment onset due to age of amyloid onset was non-linear and accelerated for amyloid onset age &gt;65. These findings demonstrate the feasibility of modelling longitudinal amyloid accumulation to enable individualized estimates of amyloid onset age from amyloid PET imaging. These estimates provide a more direct way to investigate the role of amyloid and other factors that influence the timing of clinical impairment in Alzheimer's disease.
Local neurodynamics as a signature of cortical areas: new insights from sleep
Authors: Armonaite Karolina , Nobili Lino , Paulon Luca , Balsi Marco , Conti Livio , Tecchio Franca 
Published: July 2022

AbstractSleep crucial for the animal survival is accompanied by huge changes in neuronal electrical activity over time, the neurodynamics.Here, drawing on intracranial stereo-electroencephalographic (sEEG) recordings from the Montreal Neurological Institute (MNI), we analyzed local neurodynamics in the waking state at rest and during the N2, N3, and rapid eye movement (REM) sleep phases. Higuchi fractal dimension (HFD)—a measure of signal complexity—was studied as a feature of the local neurodynamics of the primary motor (M1), somatosensory (S1), and auditory (A1) cortices. The key working hypothesis, that the relationships between local neurodynamics preserve in all sleep phases despite the neurodynamics complexity reduces in sleep compared with wakefulness, was supported by the results. In fact, while HFD awake &gt; REM &gt; N2 &gt; N3 (P &lt; 0.001 consistently), HFD in M1 &gt; S1 &gt; A1 in awake and all sleep stages (P &lt; 0.05 consistently). Also power spectral density was studied for consistency with previous investigations. Meaningfully, we found a local specificity of neurodynamics, well quantified by the fractal dimension, expressed in wakefulness and during sleep. We reinforce the idea that neurodynamic may become a new criterion for cortical parcellation, prospectively improving the understanding and ability of compensatory interventions for behavioral disorders.
A sequence labeling framework for extracting drug–protein relations from biomedical literature
Authors: Luo Ling , Lai Po-Ting , Wei Chih-Hsuan , Lu Zhiyong 
Published: July 2022

AbstractAutomatic extracting interactions between chemical compound/drug and gene/protein are significantly beneficial to drug discovery, drug repurposing, drug design and biomedical knowledge graph construction. To promote the development of the relation extraction between drug and protein, the BioCreative VII challenge organized the DrugProt track. This paper describes the approach we developed for this task. In addition to the conventional text classification framework that has been widely used in relation extraction tasks, we propose a sequence labeling framework to drug–protein relation extraction. We first comprehensively compared the cutting-edge biomedical pre-trained language models for both frameworks. Then, we explored several ensemble methods to further improve the final performance. In the evaluation of the challenge, our best submission (i.e. the ensemble of models in two frameworks via major voting) achieved the F1-score of 0.795 on the official test set. Further, we realized the sequence labeling framework is more efficient and achieves better performance than the text classification framework. Finally, our ensemble of the sequence labeling models with majority voting achieves the best F1-score of 0.800 on the test set.Database URLhttps://github.com/lingluodlut/BioCreativeVII_DrugProt
Serum Retinol Binding Protein 4 as a Potential Biomarker for Sarcopenia in Older Adults
Authors: Chang Chen-Lu , Li Yan-Ru , Wang Zhi-Yue , Li Mei-Lin , Jia Kai-Yue , Sun Hui-Xian , Wang Quan , Zhao Can , Lu Xiang , Gao Wei 
Published: July 2022

Abstract
Sarcopenia is characterized by progressive loss of muscle mass and function due to aging. Retinol-binding protein 4 (RBP4) is an adipokine with pro-inflammatory effects. However, the change of RBP4 concentration and its role in sarcopenia remains unclear. The aim of this study was to evaluate the association of serum RBP4 level with sarcopenia in the older adults. A total of 816 community-dwelling older adults aged ≥60 years were enrolled. Serum RBP4 was measured by enzyme-linked immunosorbent assay. Appendicular skeletal muscle mass index (ASMI), grip strength, and gait speed were measured. We found that serum RBP4 levels were higher in patients with sarcopenia when compared with those without sarcopenias (44.3 [33.9–57.7] vs 38.0 [28.0–48.4] μg/mL). Receiver operating characteristic curve analysis indicated that the optimal cutoff value of serum RBP4 level that predicted sarcopenia was 38.79 μg/mL with a sensitivity of 67.8% and a specificity of 53.3%. Multivariate logistic regression analysis showed that the subjects with a higher level of RBP4 had a higher risk of sarcopenia (adjusted odds ratio [OR] = 2.036, 95% CI = 1.449–2.861). Serum RBP4 concentration was negatively correlated with grip strength (r = −.098), gait speed (r = −.186), and AMSI (r = −.096). Moreover, serum RBP4 levels were higher in patients with severe sarcopenia when compared with those with moderate sarcopenia (49.0 [37.3–61.2] vs 40.4 [31.3–51.2] μg/mL). Taken together, our results demonstrate that serum RBP4 level is correlated with the risk and severity of sarcopenia in the older adults, indicating that RBP4 might serve as a surrogate biomarker for the screening and evaluation of sarcopenia.
Increased Macrophage-Specific Arterial Infiltration Relates to Noncalcified Plaque and Systemic Immune Activation in People With Human Immunodeficiency Virus
Authors: Toribio Mabel , Wilks Moses Q , Hedgire Sandeep , Lu Michael T , Cetlin Madeline , Wang Melissa , Alhallak Iad , Durbin Claudia G , White Kevin S , Wallis Zoey , Schnittman Samuel R , Stanley Takara L , El-Fakhri Georges , Lee Hang , Autissier Patrick , Zanni Markella V , Williams Kenneth C , Grinspoon Steven K 
Published: July 2022

Abstract

Background
Persistent immune activation is thought to contribute to heightened atherosclerotic cardiovascular disease (ASCVD) risk among people with human immunodeficiency virus (PWH).

Methods
Participants (≥18 years) with or without human immunodeficiency virus (HIV) and without history of clinical ASCVD were enrolled. We hypothesized that increased macrophage-specific arterial infiltration would relate to plaque composition and systemic immune activation among PWH. We applied a novel targeted molecular imaging approach (technetium-99m [99mTc]–tilmanocept single photon emission computed tomography [SPECT]/CT) and comprehensive immune phenotyping.

Results
Aortic 99mTc-tilmanocept uptake was significantly higher among PWH (n = 20) than participants without HIV (n = 10) with similar 10-year ASCVD risk (P = .02). Among PWH, but not among participants without HIV, noncalcified aortic plaque volume related directly to aortic 99mTc-tilmanocept uptake at different uptake thresholds. An interaction (P = .001) was seen between HIV status and noncalcified plaque volume, but not calcified plaque (P = .83). Systemic levels of caspase-1 (P = .004), CD14–CD16+ (nonclassical/patrolling/homing) monocytes (P = .0004) and CD8+ T cells (P = .005) related positively and CD4+/CD8+ T-cell ratio (P = .02) inversely to aortic 99mTc-tilmanocept uptake volume.

Conclusions
Macrophage-specific arterial infiltration was higher among PWH and related to noncalcified aortic plaque volume only among PWH. Key systemic markers of immune activation relating to macrophage-specific arterial infiltration may contribute to heightened ASCVD risk among PWH.

Clinical Trials Registration
NCT02542371.
Effects of Sublethal Concentrations of Insecticides on Survival and Reproduction of TwoBactroceraSpecies (Diptera: Tephritidae)
Authors: Nian Xiaoge , Luo Yaru , Ye Hui , He Xinyu , Wu Shujie , He Yurong , Wang Desen 
Published: July 2022

AbstractThe melon fruit fly, Bactrocera cucurbitae (Coquillett) and the pumpkin fruit fly, Bactrocera tau (Walker) (Diptera: Tephritidae), are important invasive pests on Cucurbitaceous hosts. The acute toxicity of five insecticides to females of these two fruit fly species was bio-assayed by membrane method, and effects of their sublethal concentration on the survival, reproduction, and ovary development of females were evaluated in the laboratory. Results showed that based on the LC50 values, both B. cucurbitae and B. tau were the most susceptible to trichlorfon. After treatment with sublethal concentration (LC30) of trichlorfon, abamectin+β-cypermethrin, spinetoram, and lambda-cyhalothrin, the female survival days of the two Bactrocera species were significantly shortened compared with the control. Moreover, the fecundity of two Bactrocera species was remarkably decreased, after exposure to abamectin+β-cypermethrin and trichlorfon LC30. However, the sublethal concentration (LC30) of insecticides had no significant influence on the egg hatchability of the fruit flies. Furthermore, after treatment with abamectin+β-cypermethrin LC30, the ovary length, width, and egg load of B. cucurbitae were significantly lower than that of the control; however, only the ovarian length and egg load of B. tau were significantly decreased on the 16th and 20th day. In conclusion, abamectin+β-cypermethrin has an excellent insecticidal activity against B. cucurbitae and B. tau.
Identifying priority areas for bat conservation in the Western Ghats mountain range, peninsular India
Authors: Raman Sreehari , Shameer Thekke Thumbath , Pooja Ushakumari , Hughes Alice C 
Published: July 2022

AbstractUnderstanding patterns of species distribution and diversity plays a vital role in biodiversity conservation. Such documentation is frequently lacking for bats, which are relatively little studied and often threatened. The Western Ghats biodiversity hotspot in peninsular India is a bat hotspot with 63 species. We conducted a comprehensive bat survey across the southern Western Ghats and used maximum entropy modeling (MaxEnt) to model the potential distribution of 37 bat species for which sufficient data were available. We generated binary maps of each species using species-specific thresholds to estimate suitable habitat areas and overlaid binary maps of species to produce bat hotspots (we use the term “bat hotspot” for regions that were suitable for more than 25 bat species). We also estimated species richness across protected area networks in the southern Western Ghats to assess the level of protection. The highest levels of species richness were found mainly along the southmost Periyar–Agastyamalai landscape. The study also identified a 1,683 km2 area of potential bat hotspot and 726 km2 (43%) of the total bat hotspots are currently within the protected area network. However, more than 50% of suitable habitats for each of the 37 species remain unprotected. Therefore, conservation decisions are needed to take into account both bat hotspots and species with restricted distributions.
Isocitrate Dehydrogenase Mutations Are Associated with Different Expression and DNA Methylation Patterns of OLIG2 in Adult Gliomas
Authors: Mo Huan , Magaki Shino , Deisch Jeremy K , Raghavan Ravi 
Published: July 2022

Abstract
Isocitrate dehydrogenase (IDH) mutant gliomas are associated with a better prognosis in comparison to adult IDH wild-type glioma and glioma-CpG island methylator phenotypes. Although OLIG2 is mainly expressed in oligodendrocytes in normal adult brain, it is expressed in both astrocytomas and oligodendrogliomas. Utilizing the clinical, DNA methylation, and RNA-sequencing data from the Cancer Genome Atlas (TCGA) for lower-grade glioma and glioblastoma cohorts, we explored the association between IDH mutation status and OLIG2 expression on transcription, DNA methylation, and gene target levels. Compared to IDH wild-type gliomas, IDH mutant gliomas showed consistently higher expression of OLIG2 transcripts. OLIG2 overexpression is a good surrogate marker for IDH mutation with an AUC of 0.90. At the DNA methylation level, IDH-mutant gliomas showed hyper- and hypomethylation foci upstream of the OLIG2 transcription start site. Underexpressed OLIG2 target genes in IDH mutant glioma were enriched in cell cycle-related pathways. Thus, the differential expression of OLIG2 between IDH mutant and wild-type gliomas reflects involvement in multiple pathways in tumorigenesis.
How China's Cognitive Warfare Works: A Frontline Perspective of Taiwan's Anti-Disinformation Wars
Authors: Hung Tzu-Chieh , Hung Tzu-Wei 
Published: July 2022

Abstract
Cognitive warfare—controlling others’ mental states and behaviors by manipulating environmental stimuli—is a significant and ever-evolving issue in global conflict and security, especially during the COVID-19 crisis. In this article, we aim to contribute to the field by proposing a two-dimensional framework to evaluate China's cognitive warfare and explore promising ways of counteracting it. We first define the problem by clarifying relevant concepts and then present a case study of China's attack on Taiwan. Next, based on predictive coding theory from the cognitive sciences, we offer a framework to explain how China's cognitive warfare works and to what extent it succeeds. We argue that this framework helps identify vulnerable targets and better explains some of the conflicting data in the literature. Finally, based on the framework, we predict China's strategy and discuss Taiwan's options in terms of cognitive and structural interventions.
Suffering to Save Lives: Torture, Cruelty, and Moral Disengagement in Australia’s Offshore Detention Centres
Authors: Barnes Jamal 
Published: July 2022

Abstract
Since Australia re-established offshore processing on Manus Island and Nauru in 2012, there have been ongoing reports that asylum seekers and refugees are being subjected to torture and cruel, inhuman or degrading treatment or punishment (CIDT). People in detention have endured indefinite detention, inadequate provision of health care, and sexual, physical, and mental harm as the government attempts to ‘stop the boats’ and prevent deaths at sea. How can Australia continue to violate the UN Convention against Torture and Other Cruel, Inhuman or Degrading Treatment or Punishment, while at the same time, promote its offshore detention policies worldwide? This article explores how Australia has engaged in moral disengagement from the pain and suffering of people in detention. Examining self-deception strategies such as denial of torture, denial of responsibility, and denial of wrongdoing, it shows not only how Australia privileged migration deterrence goals over human rights considerations, but utilized legal and humanitarian arguments to evade accountability and deny the existence of, and responsibility and wrongdoing for, torture and CIDT. This article explores the under-examined issue of moral disengagement to show how it is exacerbating the vulnerability of asylum seekers and refugees to torture and CIDT along their migration journeys.
Development of the

B

last

O

rdnance and

O

ccupational Exposure

M

easure for Self-Reported Lifetime Blast Exposures
Authors: Sours Rhodes Chandler , Sandlain Rebecca , Ollinger John , Bryden Daniel , Dittmer Travis , DeGraba Thomas J , Teslovich Theresa 
Published: July 2022

ABSTRACT

Introduction
To address the military gap in the standardized collection of lifetime blast exposures across clinical and research endeavors, researchers at the National Intrepid Center of Excellence (NICoE) completed a quality improvement project that utilized systematic, iterative focus groups that leveraged the input from various stakeholders including subject matter experts, clinical providers, and service members (SMs) to develop a comprehensive, self-report blast exposure inventory that could be completed within 5-10 minutes. This manuscript outlines the process of the development of this inventory.

Materials and Methods
This project included three phases of focus groups that occurred at the NICoE between August 2020 and March 2021 to collect feedback and input from relevant military stakeholders. The study team utilized related assessments available in the literature, together with clinical experience with the NICoE patient population, to inform the development of an initial draft inventory. Phase 1 consisted of blast injury research subject matter experts who had extensive experience researching and providing clinical care to SMs exposed to blast. Phase 2 consisted of NICoE clinicians across numerous clinical specialties. Phase 3 included current active duty patients in the NICoE intensive outpatient program.

Results
Following completion of the focus groups, a lifetime blast exposure inventory was developed in the form of a single page table including incoming, outgoing, training, and operational exposures and broken down by levels of weapon systems as well as breaching and explosive ordnance disposal exposures. In addition, select questions related to the first and most recent blast exposures and experience as an instructor for explosive ordnance disposal- and breaching-related training were included.

Conclusions
Researchers at the NICoE developed a self-report blast exposure inventory through a quality improvement project that included active, ongoing participation and feedback of clinical experts and military SMs. The end result is a brief, single page inventory that can be administered within 5-10 minutes. Although additional research is needed to refine and validate the inventory, the project team believes that the tool begins to address a long-standing gap in the DoD in the standardized collection of lifetime blast exposures.