bluuebunny/crossref_metadata_2025_split huggingface dataset:
Differences in preferences, water content, and dietary fibre of jackfruit seed crackers enriched with red beetroot (Beta vulgaris)
Authors: Astuti P , Zumar H A , Fathonah S , Ansori M 
Published: February 2022

Abstract
Increasing public attractiveness to crackers can be done by diversifying non-protein cracker products. Jackfruit seeds have potential as an additive for crackers because it contains high starch and nutrients, such as dietary fibre. The purpose of this research is to determine the differences in preference for experimental crackers as well as water content and total dietary fibre. Mean analysis was used to determine level of public preference and Kruskal-Wallis test is used to determine differences in the level of preference. To determine the difference in water content and dietary fibre, used non-homogeneous sample t-test. Preference test showed steamed and boiled-steamed jackfruit seeds treatment got an average score of 5.6 and 5.7 criteria favoured by panellist, treatment for boiled jackfruit seeds with average score of 5.4 criteria less favoured by panellist. The nutritional analysis with low water content and high dietary fibre in steamed treatment with average water content of 2.40% and total dietary fibre of 9.21. Kruskal-Wallis test showed P-value of 0.000 <0.05, meaning that there was a difference treatment of jackfruit seeds on texture preference aspect. Non-homogeneous sample t-test analysis showed P-value <0.05, meaning that there was a difference in water content and dietary fibre.
Design and production of multifunctional food oven with energy-saving gas fuel
Authors: Sumbodo W , Kriswanto  , Setiyawan A , Pamiyanto J , Hadikawuryan D H , Widodo R D , Jamari J 
Published: February 2022

Abstract
Ovens sold in the market have many features that make them easier to use but are not suitable for the needs of Small and Micro Enterprises (SME), namely large capacity, multifunction, use of gas fuel, energy-saving, and ease to operate. It is necessary to design and manufacture an oven according to the needs of SME users. The purpose of this study is to design, build, assess the feasibility, and evaluate the operating energy usage of the oven. The oven design process uses the French’s model and Quality function deployment (QFD) methods. Experiments to test the oven’s feasibility. The study’s result is that oven design validated user requirements by design experts, manufacturing experts, and users (SMEs). The oven prototype has shown performance to reduce water content according to food products with a distribution permit in Indonesia. The energy consumption of oven prototype has been compared to an electric oven similar capacity that showed that there is an energy-saving of 6.8%. Based on validation of design and product feasibility and calculation of oven energy consumption, the oven meets the small and medium enterprises (SME) users’ needs.
Analysis and solutions of traffic shift on 4G networks in the campus environment during the Covid-19 pandemic
Authors: Salim N A , Sulistyawan V N , Intan F T 
Published: February 2022

Abstract
The monitoring and management of Internet data traffic is an important requirement to be used and interpreted as a resource to make informed network management decisions. At the time of the covid-19 pandemic there was significant internet traffic changed caused by most of the students who returned home because of home-based lecture policies. Earlier Internet traffic that was in offices, college areas, schools and public places was so high even tended to overload. However, at present Internet traffic shifts to residential or residential areas. However, currently internet traffic is shifting to this problem, the telecommunications operator to do optimization to reduce expenses due to decreased income in the area around the campus. Optimization is done by dynamic carrier shut down, one carrier will be turned off if its utilization is lower than a predetermined threshold.
Design and development of temporary immersion bioreactor system controlled by microcontroller
Authors: Woowong A , Piladaeng N 
Published: February 2022

Abstract
This research aims to develop, design and construct a temporary immersion bioreactor (TIB) controlled by microcontroller. The designed TIB can control the time for plant feeding and the carbon dioxide (CO2) concentration via application. The TIB consists of 2 sets of the plant tissue culture containers. The TIB can define the feeding and the CO2 concentration control times up to 10 and 4 time periods per day, respectively. The system feeds the plants and controls the CO2 concentration during the defined time periods. The test results of the feeding time control illustrated that the TIB could set the feeding times conveniently and quickly. Moreover, the system could properly work following the set times. For the test results of the CO2 concentration control, it was found that the TIB could control the CO2 concentration in the containers during the set operating time. It took about 7, 28, 30, 36 and 21 minutes after the system started working to adjust the CO2 concentration in order to be at the set levels of <750, 1,500, 2,000, 2,500 and 3,000 ppm, respectively. The CO2 concentration control system could properly work with error less than 10%.
Microwave heating control system using genetic algorithm-based PID controller
Authors: Apriaskar E , Prastiyanto D , Malik M A , Ramadhan A E , Destanto R , Abdullah@Idris H , Osman M K 
Published: February 2022

Abstract
The superiorities of microwave heating technology have attracted many researchers for further development. Designing a satisfying temperature control system for the microwave system is one of them. To confirm that the controller can work with good system performance, the adjustment of controller parameters is important. Most previous research about microwave control systems did not focus on the tuning problem which is presented in this work. This paper provides the use of a genetic algorithm to adjust the best parameters for a PID controller. A microwave heating system with a single microwave power input and a single output temperature probe which is identified using the ARX model is examined. Evaluation of the proposed controller was conducted in the simulation environment using MATLAB. The result shows that the genetic algorithm can obtain the most optimized parameter for PID controller which can follow a certain heating pattern. The parameters for Kp, Ki, and Kd are 998.94, 79.42, and 79.78, respectively. It can minimize the value of integral absolute error for the given setpoint to 446.11.
Application of the adaptive re-use concept in historical building (case study of cigarette factory Gunung Kedu and cigarette factory Gunung Kelapa enterprises residence)
Authors: Perbawa I R H , Handayani K N , Musyawaroh  
Published: February 2022

Abstract
Cigarette Factory Gunung Kedu and Cigarette Factory Gunung Kelapa are kretek industries owned by the Atmowidjojo family. This family has a big role in the economic progress of the Kudus Kulon community. This role can be seen in the large number of jobs provided for the surrounding community. Physical relics that are still intact to date are; Atmowidjojo’s house, Nadirun’s house, office, and Gunung Kedu factory. Buildings that have historical value are important elements in the development of the city area, as the identity and image of the city. However, at this time the awareness of the public and the government regarding the preservation of buildings is quite lacking. The phenomenon that occurs in the Kudus Kulon area at this time is that many historical buildings belonging to the community are sold and torn down. Sales and demolition of buildings due to the high cost of maintaining historic buildings. Based on this importance, it is necessary to apply the concept of adaptive reuse as a sustainable step in preserving buildings that have historical value in Kudus. The purpose of this research is to study the steps for the sustainability of the application of conservation in buildings that have a history, with building conditions that are still suitable for use. The method in this research uses descriptive qualitative using a case study approach.
Green campus development of UNNES postgraduate program: potential identification and performance analysis
Authors: Prihanto T , Hardati P , Santoso E B , Wibowo A A 
Published: February 2022

Abstract
Universitas Negeri Semarang (UNNES) with the vision of conservation-minded university with international reputation continues to develop a conservation-based academic life, namely the value of caring for the environment. This vision is supported by one of the internal UNNES Green Campus Programs, namely H-BAT (green, clean and healthy). Based on the results of the H-BAT assessment in period of June 202, it showed that the achievement of the UNNES Postgraduate Program (it’s called PPs UNNES) performance was 62.24%. This performance achievement is a low indicator for PPs UNNES in its efforts to develop a green campus. The formulation of the problem that can be raised is how to improve the performance of PPs UNNES’s H-BAT achievement in the field of conservation. The purpose of this study is to identify potential and analyse campus performance in accordance with the H-BAT indicator assessment criteria. The method used in this research is descriptive exploratory. The results show that the achievement of 62.24% of the H-BAT assessment illustrates that the PPs UNNES green campus governance is not optimal, both in administration, programs, policies and implementation in the field. PPs UNNES has great potential to be able to better improve H-BAT achievement, but it seems that there are obstacles that may be the cause of the low H-BAT performance achievements in the past period. It needs a lot of efforts to optimize the existing potential so that it can fulfil the H-BAT assessment indicators more optimally.
Molecular emission dynamics from a femtosecond filament induced plasma plume
Authors: K M Muhammed Shameem , P Madhusudhan , Das Rituparna , Bharadwaj Pranav , Vinitha Nimma , Soumyashree Swetapuspa , Kumar Kushawaha Rajesh 
Published: February 2022

Abstract
In this study, we investigated the filament-induced plasma properties and the associated molecular emission features from three different non-metallic samples. Graphite, polymethyl methacrylate, and Teflon samples have been ablated using a tightly focused filament, and their emission spectra were analyzed using a time-integrated optical emission spectroscopy technique. The temporal responses and evolution dynamics of molecular species such as CN and C2 from these samples in ambient conditions are compared. The tightly focused filament was generated by focusing the Ti:Sapphire femtosecond pulses having a pulse duration of 29 fs using a short focal length external focusing system. The time-integrated intensified charge-coupled device images of air filament show that the filament survives up to a few nanosecond time duration after the onset of air plasma. The influence of physical and chemical properties of the samples during filament ablation has also been studied by characterizing the optical emission spectra. We find that the molecular signal intensity strongly depends on the sample properties and the position of the sample in the filament. The increase in molecular emission intensity from a graphite sample as a function of incident laser intensity suggests that the tightly focused filament surpasses the intensity clamping value.
Investigating aperture-based approximations to model a focused dynamic collimation system for pencil beam scanning proton therapy
Authors: Nelson Nicholas P , Culberson Wesley S , Hyer Daniel E , Smith Blake R , Flynn Ryan T , Hill Patrick M 
Published: February 2022

Abstract

Purpose. The Dynamic Collimation System (DCS) is an energy layer-specific collimation device designed to reduce the lateral penumbra in pencil beam scanning proton therapy. The DCS consists of two pairs of nickel trimmers that rapidly and independently move and rotate to intercept the scanning proton beam and an integrated range shifter to treat targets less than 4 cm deep. This work examines the validity of a single aperture approximation to model the DCS, a commonly used approximation in commercial treatment planning systems, as well as higher-order aperture-based approximations for modeling DCS-collimated dose distributions. Methods. An experimentally validated TOPAS/Geant4-based Monte Carlo model of the DCS integrated with a beam model of the IBA pencil beam scanning dedicated nozzle was used to simulate DCS- and aperture-collimated 100 MeV beamlets and composite treatment plans. The DCS was represented by three different aperture approximations: a single aperture placed halfway between the upper and lower trimmer planes, two apertures located at the upper and lower trimmer planes, and four apertures, located at both the upstream and downstream faces of each pair of trimmers. Line profiles and three-dimensional regions of interest were used to evaluate the validity and limitations of the aperture approximations investigated. Results. For pencil beams without a range shifter, minimal differences were observed between the DCS and single aperture approximation. For range shifted beamlets, the single aperture approximation yielded wider penumbra widths (up to 18%) in the X-direction and sharper widths (up to 9.4%) in the Y-direction. For the example treatment plan, the root-mean-square errors (RMSEs) in an overall three-dimensional region of interest were 1.7%, 1.3%, and 1.7% for the single aperture, two aperture, and four aperture models, respectively. If the region of interest only encompasses the lateral edges outside of the target, the resulting RMSEs were 1.7%, 1.1%, and 0.5% single aperture, two aperture, and four aperture models, respectively. Conclusions. Monte Carlo simulations of the DCS demonstrated that a single aperture approximation is sufficient for modeling pristine fields at the Bragg depth while range shifted fields require a higher-order aperture approximation. For the treatment plan considered, the double aperture model performed the best overall, however, the four-aperture model most accurately modeled the lateral field edges at the expense of increased dose differences proximal to and within the target.
New national osteoporosis guidance—implications for geriatricians
Authors: Gregson Celia L , Compston Juliet E 
Published: February 2022

Abstract
Fragility fractures are painful, debilitating, often life-changing and accounted for an estimated 2.4% of pre-pandemic health care spending in the UK. Those who are older, frail and multimorbid have the highest fracture risk and therefore the most to gain from anti-osteoporosis treatments to reduce this risk. Currently, an unacceptable treatment gap exists between those eligible for and those who receive treatment. This commentary discusses the major changes to the new, National Institute for Health and Care Excellence accredited, UK National Osteoporosis Guideline Group (NOGG) guidance (published March 2022) most relevant to the management of older people’s bone health. Changes include intervention thresholds; using fracture probabilities from FRAX; for patients too frail to undergo DXA; greater emphasis on vertebral fracture detection and the use of intravenous zoledronate as a first-line anti-osteoporosis therapy; the new concept of ‘very high fracture risk’ which should prompt consideration of use of parenteral anti-osteoporosis therapy; new guidance regarding anabolic treatment options; concerns regarding denosumab cessation; and the urgent need to get patients with a fragility fracture onto treatment to reduce re-fracture risk with follow-up to check tolerance and ensure adherence.
Rat Model of Late Gestational Alcohol Exposure Produces Similar Life-Long Changes in Thalamic Nucleus Reuniens Following Moderate- Versus High-Dose Insult
Authors: Gursky Zachary H , Klintsova Anna Y 
Published: February 2022

Abstract

Aims
Recent studies have recognized that thalamic nucleus reuniens (Re) undergoes substantial neuron loss following alcohol exposure (AE) during the brain growth spurt (BGS). As all previous studies have utilized high-dose AE paradigms, we tested whether moderate-dose AE is capable of damaging Re to a similar degree as high-dose AE.

Methods
We used a rat model of third-trimester binge AE (relative to human pregnancy) to administer ethanol to rat pups at either a high (5.25 g/kg/day) or moderate (3.00 g/kg/day) dose during the BGS (postnatal days [PD] 4–9) via intragastric intubation. In adulthood (i.e. PD72), we quantified the volume of Re as well as the total number of neurons and non-neuronal cells in the nucleus (which were further divided into microglia versus ‘other’ non-neurons), using unbiased stereological estimation of cells identified with immunofluorescent markers (i.e. nuclear label Hoechst, neuron-specific protein NeuN, and microglia-specific protein Iba1). Data were analyzed both between-treatment and correlated with peak blood alcohol concentration (BAC).

Results and conclusions
We observed significant neuronal and non-neuronal cell loss in both the high-dose and moderate-dose AE groups (relative to both procedural control and typically-developing control groups), which mediated reductions in Re volume. Outcomes did not correlate with peak BAC, further supporting that Re is vulnerable to AE-induced neurodegeneration at lower doses than previously suspected. Given the role that Re has in coordinating prefrontal cortex and hippocampus, the current study highlights the role that thalamic damage may play in the range of behavioral alterations observed in Fetal Alcohol Spectrum Disorders.
‘Or both’: A note on the alleged exclusivity of disjunction in English
Authors: Lajevardi Kaave 
Published: February 2022

Abstract
I make a point concerning the construction ‘A or B or both’ in English, to the effect that if the connective ‘or’ is understood exclusively across the board then this familiar construction cannot convey the intended inclusive sense of disjunction. If we take ‘or’ inclusively, ‘A or B or both’ has the function of emphasizing that the disjunction is inclusive; taking ‘or’ exclusively, it does nothing.
Interventions Targeting Health and Wellbeing among Nail Salon Workers: A Scoping Review
Authors: Ward Lauren , Le Aurora , Shannon Carol , Rosemberg Marie-Anne 
Published: February 2022

Abstract

Objectives
To identify existing interventions targeting the health and wellbeing of nail salon workers.

Methods
Arksey and O’Malley’s framework on reviews guided this project. The databases MEDLINE, EMBASE, Scopus, CINAHL, and Web of Science were searched. A Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) chart was used to capture the inclusion protocol.

Results
Four interventions were identified, of which one was a randomized controlled trial. Across the four interventions, there were about 424 participants that were recruited through cosmetology schools and 34 from nail salons. Interventions varied from pamphlet distribution and inspections to full-day training sessions. Intervention effectiveness was determined via pre- and post-tests and infractions frequency. Maximum follow-up time was 8 months. Outcomes included increased knowledge on exposures, fewer infractions, increased adherence to infection control practices and use of personal protective equipment, and behavior and attitude changes.

Conclusions
There is a need for further research on interventions targeting vulnerable workers in nail salons who face numerous hazards on the job. Two of the four interventions targeted nail technician trainees and their instructors, indicating the potential of early interventions before the workers officially enter the workforce.
Bioinformatics/network topology analysis of acupuncture in the treatment of COVID-19: response to methodological issues
Authors: Zhao Meidan , Wang Pengqian , Zhang Kai 
Published: February 2022

Abstract
Coronavirus disease 2019 (COVID-19) is a global pandemic and there is an urgent need to discover the therapy for COVID-19. In our original article, we first obtained the target proteins of acupuncture and related target genes of COVID-19 by searching English and Chinese databases, then Gene Ontology biological processes and enrichment analysis were performed on the overlapping targets of acupuncture with COVID-19. Moreover, the compound-target and compound-disease-target network was constructed. This is an innovative attempt to predict the potential benefits of acupuncture treatment for COVID-19. In this letter, we answered reader Zheng's comments.
Multimodal reasoning based on knowledge graph embedding for specific diseases
Authors: Zhu Chaoyu , Yang Zhihao , Xia Xiaoqiong , Li Nan , Zhong Fan , Liu Lei 
Published: February 2022

Abstract

Motivation
Knowledge Graph (KG) is becoming increasingly important in the biomedical field. Deriving new and reliable knowledge from existing knowledge by KG embedding technology is a cutting-edge method. Some add a variety of additional information to aid reasoning, namely multimodal reasoning. However, few works based on the existing biomedical KGs are focused on specific diseases.

Results
This work develops a construction and multimodal reasoning process of Specific Disease Knowledge Graphs (SDKGs). We construct SDKG-11, a SDKG set including five cancers, six non-cancer diseases, a combined Cancer5 and a combined Diseases11, aiming to discover new reliable knowledge and provide universal pre-trained knowledge for that specific disease field. SDKG-11 is obtained through original triplet extraction, standard entity set construction, entity linking and relation linking. We implement multimodal reasoning by reverse-hyperplane projection for SDKGs based on structure, category and description embeddings. Multimodal reasoning improves pre-existing models on all SDKGs using entity prediction task as the evaluation protocol. We verify the model’s reliability in discovering new knowledge by manually proofreading predicted drug–gene, gene–disease and disease–drug pairs. Using embedding results as initialization parameters for the biomolecular interaction classification, we demonstrate the universality of embedding models.

Availability and implementation
The constructed SDKG-11 and the implementation by TensorFlow are available from https://github.com/ZhuChaoY/SDKG-11.

Supplementary information
Supplementary data are available at Bioinformatics online.
Basic mechanisms in cardiogenic shock: part 1—definition and pathophysiology
Authors: Krychtiuk Konstantin A , Vrints Christiaan , Wojta Johann , Huber Kurt , Speidl Walter S 
Published: February 2022

AbstractCardiogenic shock mortality rates remain high despite significant advances in cardiovascular medicine and the widespread uptake of mechanical circulatory support systems. Except for early invasive angiography and percutaneous coronary intervention of the infarct-related artery, the most widely used therapeutic measures are based on low-quality evidence. The grim prognosis and lack of high-quality data warrant further action. Part 1 of this two-part educational review defines cardiogenic shock and discusses current treatment strategies. In addition, we summarize current knowledge on basic mechanisms in the pathophysiology of cardiogenic shock, focusing on inflammation and microvascular disturbances, which may ultimately be translated into diagnostic or therapeutic approaches to improve the outcome of our patients.