bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prediction of problem gambling by demographics, gaming behavior and psychological correlates among gacha gamers: A cross-sectional online survey in Chinese young adults
Authors: Tang Anson Chui Yan , Lee Paul Hong , Lam Simon Ching , Siu Summer Cho Ngan , Ye Carmen Jiawen , Lee Regina Lai-Tong 
Published: August 2022

ObjectiveThe objective of this study is to explore the association of problem gambling with demographics, psychological distress, and gaming behavior in young adult gacha gamers in Hong Kong.Materials and methodsCross-sectional data was collected in the first and fifth waves of COVID-19 pandemic in Hong Kong online. Participants who aged 18–25 years and had been playing gacha games over the past 12 months were recruited. Stepwise multiple regression was used to explore the association among risk of problem gambling, gaming behavior, participation in gaming activities and psychological distress. A two-sided p-value &lt;0.05 was considered as statistical significance.ResultsThree hundred and thirty-seven completed questionnaires were received with no missing data. 34.7% (n = 117) of the participants had non/low-risk of problem gambling. About 40% (n = 136) of them had moderate-risk and the remaining 25% (n = 84) were at high risk of problem gambling. A higher proportion of female participants (78.6%) were found in high-risk group as compared to 39.7% and 55.6% only in the non/low-risk and moderate-risk groups, respectively. The regression model (R2 = 0.513, F = 71.895, p &lt; 0.001) showed that 51.3% of the variance of the total problem gambling score could be explained by stress, anxiety, monthly expenses on gacha purchases, number of motives for gacha purchase and number of gambling activities engaged.ConclusionThe present study provides empirical evidence to support the association between problem gambling and microtransaction especially for gacha which is the most popular type of video game microtransaction in Asia. The established regression model suggests that gacha gamers with higher risk of problem gambling tend to have greater stress, higher anxiety level, spend more on gacha purchase, have more motives for gacha purchases and engage in more gambling activities. In contrast to the extant literature, higher proportion of female participants in high-risk group indicates that female gacha gamers are also at very high risk of becoming problem gamblers.
PD-1 inhibitor-associated type 1 diabetes: A case report and systematic review
Authors: Lin Cuiping , Li Xuan , Qiu Yu , Chen Zheng , Liu Jianping 
Published: August 2022

ObjectiveThis study aimed to summarize the clinical characteristics of programmed death receptor 1 (PD-1) inhibitor-associated type 1 diabetes so as to improve the ability of clinicians to correctly diagnose and treat it.MethodsWe reported a case of a 70-year-old woman with gastric cancer who developed hyperosmolar hyperglycemic coma during camrelizumab (a PD-1 inhibitor) treatment and was diagnosed with PD-1 inhibitor-associated type 1 diabetes. We conducted a systematic review of 74 case reports of type 1 diabetes associated with PD-1 inhibitor therapy published before June 2022.ResultsThe patient developed type 1 diabetes with hyperosmolar hyperglycemic coma after receiving camrelizumab chemotherapy for 6 months (9 cycles). We searched 69 English articles comprising 75 patients, all of whom had been treated with a PD-1 inhibitor (nivolumab or pembrolizumab) and progressed to diabetes after an average of 6.11 (1–28) cycles. Nivolumab combined with ipilimumab (a cytotoxic T lymphocyte-associated protein 4 inhibitor) had the shortest onset (4.47 cycles on average). A total of 76% (57/75) of patients developed diabetic ketoacidosis (DKA) at onset, and 50.67% (38/75) of patients had C-peptide &lt;0.1 ng/mL. Most of the patients were tested for insulin autoantibodies, with a positive rate of 33.33% (23/69); of these, 86.96% (20/23) were tested for glutamate decarboxylase antibody and 46.67% (35/75) were tested for human leukocyte antigen (HLA). HLA-DR4 was the most common type.ConclusionsThe progression of type 1 diabetes induced by PD-1 inhibitors is relatively rapid. Islet failure often occurs when detected, seriously endangering patients' lives. Patients treated with PD-1 inhibitors should closely monitor their plasma glucose level during treatment to detect, diagnose, and treat diabetes on time.
Self-care practices and associated factors among hypertension patients in public hospitals in Harari regional state and Dire Dawa City administration, Eastern Ethiopia: A multi-center cross-sectional study
Authors: Abdisa Lemesa , Balis Bikila , Shiferaw Kasiye , Debella Adera , Bekele Habtamu , Girma Sagni , Mechal Ayalnesh , Amare Eldana , Kechine Temesgen , Tari Kajela , Nigussie Kabtamu , Assefa Nega , Letta Shiferaw 
Published: August 2022

IntroductionHypertension is a silent killer that causes serious health issues in all parts of the world. Hypertension is a risk factor for cardiovascular disease, stroke, and kidney disease. Self-care practices have been identified as an important component of hypertension management. Despite the government's commitment and the interventions of various stakeholders, the burden of hypertension and its sequel remain unabated. A recent study showed that hypertension self-care practices play a vital role in controlling and managing high blood pressure, even though there is poor self-practice among hypertensive patients in Ethiopia. Therefore, this study assessed the level of self-care practices and associated factors among hypertension patients in public hospitals in Harari regional state and Dire Dawa City Administration, Eastern Ethiopia.MethodsHospital-based cross-sectional study was conducted from June 15 to July 15/2021 among 415 adult hypertensive patients on follow-up. The participants were selected using systematic sampling. Hypertension Self-Care Activity Level Effects (H-SCALE) was used to collect data through face-to-face interviews. The SPSS version 24 was used for analysis. Logistic regression analyses were done to determine the association between the outcome and independent variables. For multivariate logistic regression models, variables having a P &lt; 0.25 during bivariate analysis were candidates. The strength of the association was estimated using AOR and 95% CI. The level of statistical significance was declared at a p &lt; 0.05.ResultsThis study revealed that 52% (95% CI, 48.2–58%) had good level of self-care practices. Formal education (AOR = 3.45, 95% CI: 2.1–4.85), good knowledge about hypertension (AOR = 1.5, 95% CI: 1.17–2.1) 1.5, abstain from chewing khat (AOR = 2.01, 95% CI: 1.44–3.94), strong social support (AOR= 1.9, 95% CI: 1.16–3.1), and absence of depression (AOR = 2.03, 95% CI: 1.43–3.92) were statistically associated with a good level of self-care practices.ConclusionsThis study pointed out that about half of the participants had a good level of self-care practices. Formal education, good knowledge about hypertension, abstaining from khat chewing, good social support, and absence of depression showed associations with a good level of self-care practices. Therefore, public health interventions on hypertension self-care practices, and strengthening non-communicable diseases control programs are vital. Moreover, the provision of targeted education to patients can improve disease knowledge and self-care practices.
Case report: An outbreak of viral conjunctivitis among the students and staff of visually impaired school, Tamil Nadu, India, 2020
Authors: Madurapandian Yazhini , Rubeshkumar Polani , Raju Mohankumar , Janane Aishwarya , Ganeshkumar Parasuraman , Selvavinayagam T. S. , Kaur Prabhdeep 
Published: August 2022

IntroductionOn February 2, 2020, the head of a visually impaired school notified similar eye symptoms among the students. We investigated the cluster to confirm the diagnosis, identify potential exposures, and propose recommendations.MethodologyWe defined a case as redness/watering/discharge from any eye among the students and staff, January–February 2020. We actively searched for the cases and calculated attack rates. We drew epicurve by date of symptoms onset. We conducted a retrospective cohort study of students and staff. We collected data on potential exposures and calculated Risk Ratio (RR), 95% Confidence Interval (95%CI), and Population Attributable Risk (PAR). We sent a conjunctival swab of the three cases for microbiological analysis.ResultsWe diagnosed the cases as acute conjunctivitis and identified 39 (76%) cases among 51 individuals. All the 39 cases reported watering and redness; 28 (72%) and 12 (31%) reported eye pain and discharge, respectively. The median age of the case was 11 years (range: 6–48 years). The attack rate didn't differ significantly between males [77% (20/26)] and females [76% (19/25), p = 0.9]. The attack rate was higher among the students [86%, (38/44)] than staffs [14%, (1/7), p = &lt;0.01]. Contact with a case [RR = 2.5, 95%CI = 1.3–4.8, PAR = 51%] and staying inside campus [RR = 6.0, 95%CI = 1.0–37.3, PAR = 81%] were associated with the acute conjunctivitis outbreak. All the three conjunctival swabs were negative for bacterial growth.ConclusionClose contact with the case and staying inside the campus led to the outbreak of acute conjunctivitis among the students and staff of the visually impaired school.
Congeners-Specific Intestinal Absorption Of Microcystins In An In Vitro 3D Human Intestinal Epithelium: The Role Of Influx/Efflux Transporters
Authors: Turco Laura , Santori Nicoletta , Buratti Franca M. , Dorne Jean-Lou C. M. , Testai Emanuela 
Published: August 2022

Microcystins constitute a group of over 200 variants and are increasingly considered as emerging toxins in food and feed safety, particularly with regards to sea-food and fish consumption. Toxicity of MCs is congener-specific, being characterised by different acute potencies, likely related to the differential activity of metabolic enzymes and transporters proteins involved in their cellular uptake. However, the active transport of MCs across intestinal membranes has not been fully elucidated. Our results, obtained using a fit for purpose 3D human reconstructed intestinal epithelium, provide new information on the complex mechanisms involved in the absorption of 5 MC variants’: it is indeed characterised by the equilibrium between uptake and extrusion, since the selected congeners are substrates of both influx and efflux proteins. In the range of tested nominal concentrations (10–40 µM) fully representative of relevant exposure scenarios, none of the active tested transporters were saturated. The comparison of permeability (Papp) values of MCs variants highlighted a dose independent relationship for MC-LR, -YR and -RR (Papp x 10–7 ranged from 2.95 to 3.54 cm/s), whereas -LW and–LF showed a dose dependent increase in permeability reaching Papp values which were similar to the other congeners at 40 µM. MC-RR, -LR, -YR show absorption values around 5% of the administered dose. Due to their lipophilicity, MC-LW and -LF were also detected within the cellular compartment. The intestinal uptake was only partially attributable to OATPs, suggesting the involvement of additional transporters. Regarding the efflux proteins, MCs are not P-gp substrates whereas MRP2 and to a lesser extent Breast cancer resistance protein are active in their extrusion. Despite the presence of GST proteins, as an indication of metabolic competence, in the intestinal tissue, MC-conjugates were never detected in our experimental settings.
Social Support for Acculturative Stress, Job Stress, and Perceived Discrimination Among Migrant Workers Moderates COVID-19 Pandemic Depression
Authors: Kim Youlim , Lee Hyeonkyeong , Lee Mikyung 
Published: August 2022

Objectives: This study aimed to investigate the practical moderating effect of social support on the relationship between acculturative stress, job stress, and perceived discrimination, and depression among migrant workers during the coronavirus disease-19 pandemic as a vulnerable group susceptible to mental health problems.Methods: Data for this cross-sectional descriptive study were collected using an online survey from 214 Vietnamese and Cambodian migrant workers, who are among the largest migrant groups residing in South Korea. Participants were asked to report on acculturative stress, job stress, perceived discrimination, depression, and social support through questionnaires in their native languages.Results: The findings showed that acculturative stress affected depression, and this effect was moderated by social support. The impact of acculturative stress on depression was significant in the group with low mean scores of social support. However, the effect of the interaction of social support on the relationship of job stress and perceived discrimination to depression was not statistically significant.Conclusion: Our findings suggest the need for differentiated strategies to improve the mental health of migrant workers based on the level of social support.
Bacteriocin from Lacticaseibacillus rhamnosus sp. A5: Isolation, Purification, Characterization, and Antibacterial Evaluation for Sustainable Food Processing
Authors: Ren Shiying , Yuan Xiaoqing , Liu Fei , Fang Fang , Iqbal Hafiz M. N. , Zahran Sara A. , Bilal Muhammad 
Published: August 2022

A new Lacticaseibacillus rhamnosus strain A5 was isolated from pickle soup and characterized for its probiotic suitability. Strain A5 was Gram-positive, catalase-negative, acid-producing, and exhibited potential antibacterial activity against Escherichia coli (inhibition zone 17.3 mm), Bacillus subtilis (inhibition zone 14.5 mm), Salmonella enterica (zone of inhibition 16.1 mm) and Staphylococcus aureus (zone of inhibition 14.2 mm) by performing investigations on the disc diffusion. The cell-free supernatant of newly isolated strain A5 retained its inhibition ability of the growth of test bacteria at pH 2.0 to 5.0, temperature 121 °C for 30 min and UV irradiation for 8 h. However, the inhibitory effects of cell-free supernatant disappeared when subjected to papain, trypsin, and pepsin enzymatic treatments. By eliminating the interferences of organic acid and hydrogen peroxide, the cell-free supernatant possessed antibacterial activity against two indicator bacteria (E. coli and B. subtilis) and showed high thermal tolerance. These results indicated that the antibacterial substances produced by strain A5 were proteinaceous in nature, namely bacteriocin. The antibacterial bacteriocins in the supernatant of the strain A5 culture were further purified by ammonium sulfate fractionation and gel filtration chromatography. The purified bacteriocins also showed a pronounced inhibitory effect against E. coli and B. subtilis. The approximated molecular weight of bacteriocins was less than 14 kDa after determining by sodium dodecyl sulfate-polyacrylamide gel electrophoresis. In conclusion, the newly isolated strain A5 and its bacteriocins could be potentially applied in food preservation to prevent the risk of foodborne illness.
Anti-Correlated Plasma and THz Pulse Generation during Two-Color Laser Filamentation in Air
Authors: Yu Zhiqiang , Sun Lu , Zhang Nan , Wang Jianxin , Qi Pengfei , Guo Lanjun , Sun Quan , Liu Weiwei , Misawa Hiroaki 
Published: August 2022

The THz generation efficiency and the plasma density generated by a filament in air have been found anti-correlated when pumped by

800

nm
+
1600

nm

two-color laser field. The plasma density near zero delay of two laser pulses has a minimum value, which is opposite to the trend of THz generation efficiency and contradicts common sense. The lower plasma density cannot be explained by the static tunneling model according to the conventional photocurrent model, but it might be attributed to the electron trapping by the excited states of nitrogen molecule. The present work also clarifies the dominant role of the drifting velocity accelerated by the two-color laser field during the THz pulse generation process. The results promote our understanding on the optimization of the THz generation efficiency by the two-color laser filamentation.
Partially coherent spiral phase contrast imaging with a 3D-like effect
Authors: Cheng Siyang , Liu Yifan , Yu Panpan , Wu Yijing , Wang Ziqiang , Li Yinmei , Gong Lei 
Published: August 2022

Abstract
Spiral phase contrast (SPC) imaging provides an effective way to isotropic edge detection for biomedical applications. Here, we present a computational SPC imaging method which combines the partially coherent illumination with the symmetry-breaking spiral phase filtering. Such an operation enables the SPC imaging to generate sharp, high-contrast and pseudo three-dimensional edge images that are almost free of speckle. The superior performance is demonstrated by imaging both amplitude and phase objects, and the speckle suppression is validated by comparing the coherent and partially coherent imaging results. This computational SPC method is expected to bring potential advantages to phase contrast imaging modality.
Evaluation of electroluminescence of AlGaN/GaN HEMT on free-standing GaN substrate
Authors: Ma Qiang , Ando Yuji , Tanaka Atsushi , Wakejima Akio 
Published: August 2022

Abstract
This paper investigated electroluminescence (EL) in AlGaN/GaN high electric mobility transistors fabricated on a free-standing GaN substrate (GaN-on-GaN) with ones on a SiC substrate (GaN-on-SiC) as a reference. When a drain voltage (V
ds) of the GaN-on-GaN was increased, the EL peak was kept beside the gate, indicating that the highest electric field region stayed in the vicinity of the gate. On the other hand, EL of the GaN-on-SiC shifted from the gate to the drain electrode under an increased V
ds. Our results indicate that the high-electric-field tolerance of GaN-on-GaN is higher than that of GaN-on-SiC, indicating that GaN-on-GaN is more suitable for high-voltage operation.
Cryogenically cooled 2.8 μm Er:YAP laser with watt-level output power
Authors: Li Enhao , Yao Weichao , Uehara Hiyori , Yasuhara Ryo 
Published: August 2022

Abstract
We report the first watt-level, cryogenically cooled Er:YAP laser operating in the 3 μm spectral region. The spectroscopic properties of a 5 at% Er:YAP crystal were studied at cooling temperatures ranging from 77–290 K. The fluorescence lifetime of the 4I11/2 level associated with the 3 μm laser transition decreased with an increase in temperature; whereas, the lifetime of the 4I13/2 level increased with an increase in temperature. Moreover, over 1 W of output power at 2798 nm was achieved from the liquid-nitrogen-cooled Er:YAP laser with a slope efficiency of 20%, and the limitations to higher output power were discussed.
Hubungan Timbal Balik dan Faktor PendidikanYayasan Pendidikan Islam Institut Agama Islam Nusantara Batang Hari
Authors: Sukatin Sukatin , Hildinniyah Hildinniyah , Misnawati Misnawati , Salsabila Salsabila , Rindiyani Rindiyani 
Published: August 2022

Pendidikan adalah salah satu upaya manusia untuk bisa

menggapai cita-citanya, sebagaimana definisi pendidikan itu
sendiri adalah aktivitas atau usaha manusia untuk menumbuh
kembangkan potensi-potensi bawaan baik jasmani maupun
rohani sesuai dengan nilai-nilai yang ada di dalam masyarakat
dan kebudayaan untuk memperoleh hasil dan potensi. Tujuan
penelitian ini yaitu untuk mengetahui pengertian faktor
pendidikan, untuk mengetahui macam-macam faktor pendidikan
dan untuk mengetahui bagaimana hubungan timbal balik antar
faktor pendidikan. Jenis penelitian yang digunakan adalah model
penelitian kualitatif dengan kajian literatur. Hasil penelitian yang
didapat perlu diingat bahwa pendidikan bermaksud melayani
kebutuhan masyarakat dalam arti menambah kemampuan
masyarakat untuk dapat bertahan dan mengembangkan diri
dalam semua aspek kehidupan. Selain itu tanpa adanya hubungan
dengan masyarakat, sekolah tidak dapat berkembang karena
masyarakat juga membantu sekolah dalam mengatasi
permasalahan-permasalahan dalam pendidikan.
Pendidikan adalah salah satu upaya manusia untuk bisa
menggapai cita-citanya, sebagaimana definisi pendidikan itu
sendiri adalah aktivitas atau usaha manusia untuk menumbuh
kembangkan potensi-potensi bawaan baik jasmani maupun
rohani sesuai dengan nilai-nilai yang ada di dalam masyarakat
dan kebudayaan untuk memperoleh hasil dan potensi. Tujuan
penelitian ini yaitu untuk mengetahui pengertian faktor
pendidikan, untuk mengetahui macam-macam faktor pendidikan
dan untuk mengetahui bagaimana hubungan timbal balik antar
faktor pendidikan. Jenis penelitian yang digunakan adalah model
penelitian kualitatif dengan kajian literatur. Hasil penelitian yang
didapat perlu diingat bahwa pendidikan bermaksud melayani
kebutuhan masyarakat dalam arti menambah kemampuan
masyarakat untuk dapat bertahan dan mengembangkan diri
dalam semua aspek kehidupan. Selain itu tanpa adanya hubungan
dengan masyarakat, sekolah tidak dapat berkembang karena
masyarakat juga membantu sekolah dalam mengatasi
permasalahan-permasalahan dalam pendidikan
Reassessing the Concept of Peace in the Concert of Europe: A European Model of Security Based upon Cooperation of States against People
Authors: Gülboy Burak Samih 
Published: August 2022

Concert of Europe was a system that was built for the purpose of maintaining the status quo between the European states and the means by which the system rested were constructed during the course of the Congress of Vienna. The Holy Alliance and the Quadruple Alliance (later Quintet) not only enabled Europe's Great Powers to cooperate in building and maintaining order, but also succeeded in creating common values that would keep cooperation alive.
While the liberal and nationalist ideas brought by the French Revolution and spread by Napoleon's campaigns were alive both in European societies and on the political map drawn by Napoleon in 1815, the victorious major powers were aware that the peace was to be established both by the suppression of these ideas and by reformation of the map. For this reason, the absolutist values and structure before the French Revolution formed the reference points that would form the basis of the new peace.
This article aims to analyze the peace on which the so-called European Harmony is based, within the framework of international relations literature.
TRANSFORMATION OF THE FINANCIAL MECHANISM OF INNOVATION IN ENSURING THE ECONOMIC SECURITY OF THE RUSSIAN FEDERATION
Authors: Дзыгман Александр Сергеевич , Кочкин Альберт Камович , Фонин Кирилл Александрович , Хутинаева Кристина Ибрагимовна , Кругляк Людмила Ивановна 
Published: August 2022

В статье систематизированы теоретические подходы к определению сущности финансового механизма инноваций в контексте необходимости его трансформирования в современных условиях для обеспечения национальной безопасности РФ.
The article systematizes theoretical approaches to determining the essence of the financial mechanism of innovation in the context of the need for its transformation in modern conditions to ensure the national security of the Russian Federation.
«FAKE» NEWS AS A TOOL FOR MANIPULATING THE SECURITIES MARKET
Authors: Малышенко Константин Анатольевич , Малышенко Вадим Анатольевич , Анашкина Марина Викторовна , Анашкин Дмитрий Викторович 
Published: August 2022

В статье рассматривается механизм и результаты влияния ложной информации (фейков) на рынок ценных бумаг. Изучены основные проблемы борьбы с информационным манипулированием, основанным на распространении фейков. Выделены основные задачи, требующие реализации с целью решения выявленных проблем.
The article discusses the mechanism and results of the influence of false information (fakes) on the securities market. The main problems of combating information manipulation based on the spread of fakes are studied. The main tasks that need to be implemented in order to solve the identified problems are highlighted.