bluuebunny/crossref_metadata_2025_split huggingface dataset:
Measles delay in India: the role of parents’ behaviour
Authors: Roy Dipankar , Debnath Avijit , Sarma Munmi , Roy Dipanjan , Das Kinnor , Roy Joydeep , Paul Sandip Rudra , Dey Biraj , Das Pinak Pratim 
Published: May 2022

Background: Objectives were to identify the factors influencing the timeliness of measles immunisation in India, as well as to explore whether parental behaviour in health care seeking facilities varies depending on the gender of child.Methods: A cross-sectional study was undertaken in India using secondary data from the fourth phase of the district level household and facility survey (DLHS 4). To estimate the age-specific coverage rates scientifically and thoroughly Kaplan-Meier survival analysis was applied. The risk factors for delayed measles immunisation were identified by using cox proportional hazard regression model.Results: Individual factors, social factors, awareness, and facilitatory factors all have a significant impact on the timeliness of measles immunisation in India. Additionally, it can also be concluded that in the case of a male child, institutional delivery significantly improves health-seeking behaviour among the parents compared to a female child. Conclusions: Numerous elements like the place of residence, economic position, and caste limit the timeliness of measles immunisation in India. Parents' health-seeking behaviour is also significant in the list of influential factors, like mother’s antenatal visit during pregnancy, the child's place of delivery, and motivation for child immunisation. In India child's gender and birth order discovered to have an impact on measles immunisation timeliness. Furthermore, we discovered that parents' health-seeking behaviour is not gender-neutral, but rather favours male child more.
Business Strategies of Banks and Online Crowdfunding Platforms, Based on the Markets in North and South America
Authors: Dziuba Dariusz T. 
Published: May 2022

Purpose of the study: The purpose of this article is to answer a few research questions: what business strategies are banks pursuing regarding crowdfunding platforms (in particular, lending); what forms of partnership do they implement on the continents of the Americas; what is the scope of implementation (use) of crowdfunding methods in banks on the continents of North and South America; how can the size of this market segment be estimated.
Methodology: The applications (platforms) of crowdfunding in individual banks from North and South America are analyzed. Based on the resources of the Internet, the implementation of banking crowdfunding and business strategies of the examined electronic platforms were identified.
Main findings: The considerations distinguished the market segment of banking crowdfunding in the Americas, as well as the implemented business strategies of banks regarding online platforms. The dominant share of the USA on a global scale was shown (186 projects).
Application of the study: The presented research relates to various scientific fields, e.g. economics and finance (alternative finance) or business informatics.
Original/Novelty of the study: The research managed to separate and estimate the size of the market segment of banking crowdfunding on the continents of North and South America.
Canine Reproductive Disorders at Veterinary Clinical Complex, College of Veterinary Science, Guwahati, India: A Retrospective Study from 2016 to 2021
Authors: Bhuyan M. , Baruti M. , Deka R. , Deka A. , Bappu H. Phunchu , Pachani S. , Das C. 
Published: May 2022

Background: Study on the reproductive health of dogs is a matter of concern since it affects the existence of future generation. There are various reproductive ailments that may affect a dog in its lifetime. The present study was aimed to find out the incidence of different reproductive disorders in canine populations reported at the Veterinary Clinical Complex (VCC), College of Veterinary Science, Guwahati, India in respect of breed, age, sex and season. Methods: The study was conducted on canine populations reported at the VCC, College of Veterinary Science, Guwahati, India during the period from 1/03/2016 to 28/02/2021. Clinical cases were grouped based on their breed, age, sex and the season and the type of various reproductive ailments and their incidence was worked out. Result: The overall incidence of reproductive disorders in dogs was 2.45%. Labradors had the maximum incidence of reproductive ailments (24.79%) followed by local breeds (17.52%) and the least was in Dachshund (2.56%). The animals under the age group 1.1 to 4.0 years appeared to have the highest incidence (47.86%) of reproductive ailments and the lowest (12.39%) was in 10.1 to 13.0 years of age group. The highest incidence of reproductive ailments was recorded in female dogs (96.15%). In canine population, summer resulted in higher (35.86%) incidence of reproductive disorders.
An Integrated Approach for Simultaneous Selection of Stable and High Yielding Genotypes in Lentil (Lens culinaris Medikus)
Authors: Verma S.K. , Panwar R.K. , Gaur A.K. , Bisht Charu , Deep Harsh , Yadav Harikant , Chauhan Charupriya 
Published: May 2022

Background: Lentil is a major rabi pulse crop and is known for its protein rich grains. It is important to develop area-specific high yielding varieties of lentil. Methods: The present study was conducted with 24 lentil genotypes grown at three different locations of Uttarakhand for two consecutive years 2018-19 and 2019-20. The average of sum of ranks (ASR) of parametric and non-parametric measures along with yield stability index was used in present study to identify the high yielding and stable lentil genotypes. Result: The pooled ANOVA revealed the presence of significant differences among genotypes, environments and G × E interaction effects. The ASR method in combination with YSI was found to be effective in identifying high yielding as well as stable genotypes. The genotypes PL 8, IPL 315, DPL 15 and PL 7 were found as most stable and high yielding genotypes.
Knowledge management and intellectual capital in the business model innovation of Costa Rican manufacturing firms
Authors: Alfaro-Ramos Alfredo Elías , Ferreras-Méndez José Luis 
Published: May 2022

The purpose of this article is to analyze the impact of knowledge management and intellectual capital on the ability of companies to generate business model innovation. To evaluate the proposed hypotheses, we surveyed a final sample of 100 Costa Rican manufacturing companies and analyzed the data using Partial Least Squares Structural Equation Modeling (PLS-SEM). The results show that knowledge management positively contributes to the development of business model innovations. Similarly, intellectual capital has a direct positive influence on business model innovation. However, the direct contribution intellectual capital depends on the adoption of practices that encourage knowledge management in companies
The Analysis of Corporate Crime in Indonesia’s Intellectual Property Laws
Authors: Weriansyah Aditya , Ramadani Alvin Prima 
Published: May 2022

<p><em>White-collar crime</em> is a type of crime that involves a large number of individuals, is carried out in a structured, large-scale manner, and results in significantly greater losses than conventional crimes. Given the growing number of organizations, the potential for white-collar crime is currently reasonably high. Corporations are able to commit various crimes, particularly those motivated by profit, such as infringements on intellectual property rights. Given that many of today's intellectual property rights holders are corporations, corporations and intellectual property rights have a strong link. This is understandable given that firms have more resources and cash to invest in developing new products that can be protected by intellectual property rights. As a result of the tight relationship between intellectual property rights and corporations, the government must be aware of potential intellectual property rights violations committed by corporations. This article aims to see if the current set of intellectual property rights legislation can handle corporate crimes. The method employed in this research is a normative juridical method with a statutory approach to produce clear findings from the formulation of corporate crime under intellectual property rights regulations. The study's findings demonstrate how unprepared existing clusters of intellectual property regulations are to deal with prospective corporate criminal activities. The criteria and system of corporate responsibility, as well as alternative consequences for firms, are pretty minimum in these numerous statutes, starting with the framing of the issue of punishment. As a result, based on vicarious liability theory and the corporate culture model, this article proposes that corporations be recognized as punishable entities under all laws controlling intellectual property rights and the establishment of firm standards and corporate obligations. In addition, this study offers suggestions for the types and amounts of punishments that might be appropriate for corporations.</p>
A Comparative Analysis of the Impeachment Procedures in Nigeria and Indonesia: A Need for a Paradigm Change
Authors: Anele Kalu Kingsley 
Published: May 2022

Although impeachment as the outcome of constitutionalism is significant in good governance, narrow political affiliations, institutional corruption, and the absence of democratic tenets among politicians hamper its proper application in Nigeria and Indonesia. The impeachment in both countries reveals a weaponization of the process for parochial gains and there is a penchant for using the process to remove elected officials for personal and political reasons. This study comparatively analyzes the impeachment procedures in Nigeria and Indonesia to suggest measures to strengthen and safeguard the procedures from abuse. The methodology deployed in this study is essentially a desk review of both primary and secondary materials. Given the comparative analysis of the commonalities and variant impeachment procedures in Nigeria and Indonesia, the application of the constitutional provisions for impeachment in both countries remains fraught with neo-patrimonialism and narrow party considerations, exacerbated by corruption, selfish interests, and ulterior motives to be in power endlessly. Moreover, wieldy impeachment provisions and weak institutional regimes propagate the abuse of impeachment. Hence, public participation in the impeachment process, amendment of the impeachment provisions, appointment of judges by independent bodies, and the prosecution of corrupt politicians and judges by effectively implementing extant anti-corruption laws are some of the steps to suppress the abuse of impeachment in Nigeria and Indonesia. While these measures are vigorously implemented, the abuse of the impeachment procedures will be repressed.
KEYWORDS: Constitutionalism, Impeachment Procedures, Indonesia, Nigeria.
Effect of Massage on treatment of preterm feeding intolerance: Study protocol for a randomized controlled trial
Authors: Peng Nan , Fu Lizhen , Li Rui , Liang Xiaohua , Lu Qi 
Published: May 2022

Abstract
Introduction: Feeding intolerance (FI) is a common neonatal disease, which may badly influence infants’ health. According to previous study, massage could prevent preterm feeding intolerance, promote maturation of gastrointestinal function and weight gain, but rarely used as an adjuvant treatment of feeding intolerance. This trial aims to evaluate the effectiveness of massage on treatment of FI.Method: The randomized controlled trial is to be conducted in Chongqing, China. 104 preterm infants whose gestational age between 28-34 weeks and birth weight between 1000g-2000g with diagnosis of feeding intolerance will be involved in the study. Participants will be stratified by birth weight (1000-1499g or 1500-2000g), and randomized to either the intervention group, who will receive massage twice a day for 7 days on the basis of routine treatment, or the control group, who will not receive any intervention except for routine treatment. Researchers blinding to group allocation will be maintained. Primary outcomes include the time from the initiation of enteral nutrition to total enteral nutrition. Secondary outcomes include duration of vomiting and abdominal distension(day), gastric residual volume, weight gain, change of length and head circumference during hospitalization, length of hospital stay (day), change of abdomen circumference（cm）, duration of diarrhea. Data will be collected in CRFs, and analyzed after data for the entire sample has been collected.Discussion: This study has the potential to provide evidence to inform that massage will improve feeding tolerance, growth and development as well as metabolism of body. This will enable us to develop a convenient and efficient way for curing preterm feeding intolerance, and improve infants’ long-term health outcomes.Trial registration: Chinese Clinical Trial Registry, ChiCTR2100045033, Registered on 3rd April 2021
Distributions, compositions, and ecological risk assessment of typical pollutants in surface sediment of Xihe River, China
Authors: Sun Xun , Yan Zheng , Ke Xin 
Published: May 2022

Abstract
Distributions and compositions of six phthalic acid esters (PAEs), eight phenol compounds and seven heavy metals in riverbed sediments of the Xihe River in Shenyang, China. The ecological risks of these typical pollutants were investigated and evaluated based on the risk quotient (RQ) and potential ecological risk index (PERI) methods. The concentrations of total ∑6PAEs, ∑8phenols and ∑7heavy metals in sediments varied from 92.83 to 293.66 µg/g dw, 8.87 to 83.73 µg/g dw and 0.46 to 419µg/g dw. The main pollutants in Xihe River sediments are DEHP, DIBP, phenol, P-methylphenol and Cd. More than half target PAEs and phenol compounds in sediment of the Xihe River exhibited medium or high ecological risk. Cd poses a very high ecological risk to the Xihe River Basin. It is imperative to take some effective measures to reduce the pollution of those contaminants.
CD73 molecule inhibitor upregulates miR16 expression in experimental glioblastoma and inhibits angiogenesis by targeting VEGF
Authors: Arab Samaneh , Ghasemi Sahar , Bahraminasab Marjan , Ghanbari Ali , Heidari Mina , Kokhaei Parviz , Asgharzade Samira 
Published: May 2022

Abstract
The function of CD73 (cluster of differentiation 73), an enzyme that is involved in adenosine (ADO) generation, in glioblastoma development has been demonstrated. However, the details of its molecular mechanisms have not been fully realized. Due to the significance of angiogenesis in cancer progression, invasion, and metastasis, in this study, it was intended to evaluate the impact of CD73 inhibition by adenosine 5′-(α, β-methylene) diphosphate (APCP) on the angiogenesis process of experimental orthotopic glioblastoma at mRNAs, microRNAs, and proteins levels. According to the real time-poly chine reaction (RT-PCR) findings, CD73 inhibition decreased glioblastoma angiogenesis by reducing vascular endothelial growth factor (VEGF) and hypoxia-inducible factor 1-alpha (HIF-1α) expression. Furthermore, immunohistochemical staining showed that this treatment protocol attenuated the expression of VEGF and CD31. Moreover, APCP treatment in the glioblastoma model rats significantly increased miR-16 expression, but no significant change in expression in miR-29A was observed. The results identified that the treatment did not induce systemic damage or significant body weight loss. Our findings indicate that CD73 inhibition can diminish tumor new vessel generation by inhibiting the molecules involved in this process, thereby CD73 may be a practical target and provide novel opportunities for improving the treatment of malignant brain tumors.
High mesothelin expression is correlated with non-squamous cell histology and poor survival in cervical cancer: A retrospective study
Authors: Takamizawa Shigemasa , Yazaki Shu , Kojima Yuki , Yoshida Hiroshi , Kitadai Rui , Nishikawa Tadaaki , Shimoi Tatsunori , Sudo Kazuki , Okuma Hitomi Sumiyoshi , Tanioka Maki , Noguchi Emi , Uno Masaya , Ishikawa Mitsuya , Kato Tomoyasu , Fujiwara Yasuhiro , Yonemori Kan 
Published: May 2022

Abstract
Background: Mesothelin (MSLN) is a cell-surface glycoprotein found in various solid tumors. Cancer therapies targeting MSLN have been developed in recent years; however, the available information on MSLN expression in cervical cancer is limited. This study aimed to evaluate MSLN expression in various histological types of cervical cancer and examine its relationship with prognosis.Methods: This retrospective study included patients with cervical cancer who underwent primary surgery between January 2000 and December 2020 at our institution. MSLN expression was evaluated by immunohistochemistry using clone SP74 and defined as positive if MSLN was expressed at any intensity. High MSLN expression was defined as an intensity of ≥ 2+ in ≥ 30% of tumor cells. The association between MSLN expression and clinicopathological factors was evaluated.Results: Overall, 123 patients were identified, and 140 tumor samples, including 17 paired primary and metastatic samples, were evaluated. Concerning histological type, 67 patients had squamous cell carcinoma (SCC), whereas 56 had non-SCC. MSLN expression was observed in 98.4% (121/123) of primary tumors. High MSLN expression was observed in 63.4% of samples (78/123), but it differed between the histological types (49.2% for SCC vs. 80.4% for non-SCC, p < 0.001). There was a significant correlation between MSLN expression in primary and metastatic lesions (Rs = 0.557, p = 0.015). In patients with common histological types, overall survival (OS) was shorter in the high MSLN expression group than in the low MSLN expression group (hazard ratio, 3.53; 95% confidence interval, 1.16–15.3, p = 0.03).Conclusions: MSLN was highly expressed in patients with cervical cancer, especially in those with non-SCC. High MSLN expression in the primary lesion was significantly associated with poor OS, and its expression was maintained in metastatic lesions. Our findings indicate that MSLN may be an attractive therapeutic target for cervical cancer.Trial registration: retrospectively registered
First Peoples and scientists concur that ‘fairy circles’ are termite linyji
Authors: Walsh Fiona , Kendrick Peter , Evans Theo , Moore Danae , Nelson Matilda , Oldham Carolyn , Schofield Josef , Sparrow Ashley , experts Martu elders and experts Martu elders and 
Published: May 2022

Abstract
Scientists aspire to ‘discover’ new environmental phenomena; they rarely consider the existing knowledge of First Peoples. The scientific debate1 over ‘fairy circles’ (regular bare patches within arid grasslands) is a case in point. Ecologists visiting Australia used brief field observations and numerical modelling to explain ‘fairy circles’ as plants responding to dispersion of water and nutrients2,3. By contrast, Australian Aboriginal people have long understood the bare patches to be created by termites. They have used linyji (Manyjilyjarra language) in their food economies and for other domestic or sacred purposes. They transfer intergenerational knowledge of termite ecology through talk and demonstration, art and song. Aboriginal art and narratives, and scientific field measurements confirm Aboriginal knowledge that ‘fairy circles’ are pavement-nests occupied by harvester termites. Aboriginal people’s observations and uses of termites and pavements are sophisticated; linyji are real, ‘fairy circles’ are not. Some scientists are not familiar with First Peoples or their knowledge systems. However, embracing First Peoples and their knowledge can provide a deeper understanding of ecological systems than is possible from short visits to landscapes. Co-research between First Peoples and scientists leads to better understanding and management of ecological systems and supports intergenerational learning across diverse cultures.
Obliquity-paced Antarctic ice-volume fluctuations during the late Oligocene
Authors: Brzelinski Swaantje , Bornemann André , Liebrand Diederik , Peer Tim van , Wilson Paul , Friedrich Oliver 
Published: May 2022

Abstract
The late Oligocene (~27.8–23 My ago) offers an opportunity to study past climate variability under high CO2 warmer-than-present conditions with Antarctic-only ice sheets (AIS) involved. Here, we present new high-resolution geochemical records from exquisitely well-preserved benthic foraminifera recovered from the northwestern Atlantic Ocean for the late Oligocene, when AIS size and stability are debated. We report deep-sea temperature and Antarctic ice-volume changes showing four glacial-interglacial ~40-thousand-year cycles paced by obliquity. Our records indicate changes in ice volume of up to ~19 ± 9.5 ×106 km3 of ice, equivalent to 70 % of the modern AIS. Ice-volume estimates for late Oligocene interglacials are small enough to be comfortably accommodated by a wholly land-based AIS but, for three of the four glacials studied, ice sheets likely advanced beyond the Antarctic coastline onto the continental shelves, introducing ocean-warming as a driving mechanism of rapid ice-sheet melting. The amplitude of ice-volume change during these late Oligocene glacial-interglacial cycles are comparable to those of the late Pliocene and early Pleistocene when glacial-interglacial cycles were strongly influenced by the advance and retreat of northern hemisphere ice sheets. Our findings demonstrate that, under late Oligocene warmer-than-present climate conditions, the AIS was vulnerable to melting driven by both bottom-up (ocean) and top-down (atmospheric) warming.
Tumour mutations in long noncoding RNAs enhance cell fitness
Authors: Esposito Roberta , Lanzós Andrés , Polidori Taisia , Guillen-Ramirez Hugo , Merlin Bernard Mefi , Mela Lia , Zoni Eugenio , Büchi Isabel , Hovhannisyan Lusine , McCluggage Finn , Medo Matus , Basile Giulia , Meise Dominik , Ramnarayanan Sunandini , Zwyssig Sandra , Wenger Corina , Schwarz Kyriakos , Vancura Adrienne , Bosch-Guiteras Núria , Julio Marianna Kruithof-de , Zimmer Yitzhak , Medová Michaela , Stroka Deborah , Fox Archa , Johnson Rory 
Published: May 2022

Abstract
Long noncoding RNAs (lncRNAs) can act as tumour suppressor or oncogenes to contrast/promote tumour cell proliferation via RNA-dependent mechanisms. Recently, genome sequencing has identified elevated densities of tumour somatic single nucleotide variants (SNVs) in lncRNA genes. However, this has been attributed to phenotypically-neutral “passenger” processes, and the existence of positively-selected fitness-altering “driver” SNVs acting via lncRNAs has not been addressed. We developed and used ExInAtor2, an improved driver-discovery pipeline, to map pancancer and cancer-specific mutated lncRNAs across an extensive cohort of 2583 primary and 3527 metastatic tumours. The 54 resulting lncRNAs are mostly linked to cancer for the first time. Their significance is supported by a range of clinical and genomic evidence, and display oncogenic potential when experimentally expressed in matched tumour models. Our results revealed a striking SNV hotspot in the iconic NEAT1 oncogene, which was ascribed by previous studies to passenger processes. To directly evaluate the functional significance of NEAT1 SNVs, we used in cellulo mutagenesis to introduce tumour-like mutations in the gene and observed a consequent increase in cell proliferation in both transformed and normal backgrounds. Mechanistic analyses revealed that SNVs alter NEAT1 ribonucleoprotein assembly and boost subnuclear paraspeckles. This is the first experimental evidence that mutated lncRNAs can contribute to the pathological fitness of tumour cells.