bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of sleep quality on the association between problematic internet use and quality of life in people with substance use disorder
Authors: Saffari Mohsen , Chen Hsin-Pao , Chang Ching-Wen , Fan Chia-Wei , Huang Shih-Wei , Chen Jung-Sheng , Chang Kun-Chia , Lin Chung-Ying 
Published: August 2022

Background
Problematic internet use, especially in people with substance use disorder, may negatively affect their quality of life (QoL). However, it is unclear whether sleep quality is a key mediator in the association between problematic internet use and QoL among people with substance use disorder.

Aims
This study aimed to investigate the relationship between problematic internet use and QoL and how sleep quality may mediate the association between these two variables.

Method
Overall, 319 people (85% male) with substance use disorder (mean age 42.2 years, s.d. 8.9) participated in a cross-sectional study in Taiwan. The Smartphone Application-Based Addiction Scale, Bergan Social Media Addiction Scale, Internet Gaming Disorder-Short Form, Pittsburgh Sleep Quality Index and World Health Organization Quality of Life Questionnaire Brief Version were used.

Results
The prevalence of sleep problems was 56%. There were significant and direct associations between sleep quality and two types of problematic internet use, and between sleep quality and different dimensions of QoL. All types of problematic internet use were significantly and negatively correlated with QoL. Mediated effects of sleep quality in relationships between the different types of problematic internet use and all dimensions of QoL were significant, except for problematic use of social media.

Conclusions
Different types of problematic internet use in people with substance use disorder may be directly associated with reduced QoL. Sleep quality as a significant mediator in this association may be an underlying mechanism to explain pathways between problematic internet use and QoL in this population.
Improving treatment of patients with psychosis in low-and-middle-income countries in Southeast Europe: Results from a hybrid effectiveness-implementation, pragmatic, cluster-randomized clinical trial (IMPULSE)
Authors: Jovanović N. , Russo M. , Pemovska T. , Francis J. J. , Arenliu A. , Bajraktarov S. , Džubur Kulenović A. , Injac Stevović L. , Novotni A. , Andrić Petrović S. , Radojičić T. , Ribić E. , Konjufca J. , Marić N. P. 
Published: August 2022

Abstract

Background
In Southeast Europe (SEE) standard treatment of patients with psychosis is largely based on pharmacotherapy with psychosocial interventions rarely available. DIALOG+ is a digital psychosocial intervention designed to make routine care therapeutically effective. This trial simultaneously examined effectiveness of DIALOG+ versus standard care on clinical and social outcomes (Aim 1) and explored intervention fidelity (Aim 2).

Methods
A hybrid type II effectiveness–implementation, cluster-randomized trial was conducted in five SEE countries: Bosnia and Herzegovina, Kosovo*, Montenegro, North Macedonia, and Serbia. The intervention was offered to patients six times across 12 months instead of routine care. The outcomes were subjective quality of life (primary), clinical symptoms, satisfaction with services, and economic costs. Intervention fidelity was operationalized as adherence to the protocol in terms of frequency, duration, content, and coverage. Data were analyzed using multilevel regression.

Results
A total of 81 clinicians and 468 patients with psychosis were randomized to DIALOG+ or standard care. The intervention was delivered with high fidelity. The average number of delivered sessions was 5.5 (SD = 2.3) across 12 months. Patients in the intervention arm had better quality of life (MANSA) at 6 months (p = 0.03). No difference was found for other outcomes at 6 months. Due to disruptions caused by the COVID-19 pandemic, 12-month data were not interpretable.

Conclusions
DIALOG+ improved subjective quality of life of individuals with psychosis at 6 months (after four sessions), albeit with small effect size. The intervention has the potential to contribute to holistic care of patients with psychosis.
Exercise is Medicine on Campus: A Scoping Review of Evidence 2009 to 2021 and Call to Action
Authors: Peterson Neil E. , Zera Jacquelyn N. , Tompkins Connie L. , Rothermel Megan A. , Davidson Carrie , Mandla Shelby , Jeffreys-Heil Renee , Shirazi Zainab , Stuhr Robyn M. , Winters Carena S. 
Published: August 2022

Abstract
The Exercise is Medicine On Campus (EIM-OC) program began in 2009 at Chatham University by Dr. Robert Sallis, Dr. Carena Winters, and ACSM leadership. The vision of EIM-OC is “to see all campus and community members across multiple disciplines discover, share, and adopt the principles of EIM that will help change the culture of physical activity and chronic disease prevention and management campus wide.” Although EIM-OC maintains close track of programmatic details, such as the number of registered and recognized institutions, a comprehensive review of EIM-OC publications has not been previously reported. The purpose of this scoping review was to 1) identify and examine all peer-reviewed evidence of EIM-OC, including scholarly articles and published abstracts of presentations; 2) analyze the key themes of EIM-OC implementation and outcomes; and 3) identify gaps in the literature. The scoping review covered all peer-reviewed publications, including scholarly articles and published abstracts, from 2009 to December 2021. In total, 9 scholarly articles and 46 published abstracts were included in this review. The articles and abstracts covered a wide range of topics, including gold level (physical activity assessment and exercise referral), silver level (physical activity education), and bronze level (physical activity awareness and promotion) activities, as well as evaluation of EIM-OC programming. Now that EIM-OC programming is firmly established, we now call on campuses and leaders to strengthen their reporting of EIM-OC outcomes at all levels: gold, silver, and bronze. Publishing research evidence will strengthen EIM-OC programming and initiatives. Specifically, we encourage publishing scholarly articles and using broad means for increasing dissemination.
Radiomics based on diffusion-weighted imaging for differentiation between focal-type autoimmune pancreatitis and pancreatic carcinoma
Authors: Shiraishi Megumi , Igarashi Takao , Hiroaki Fujioka , Oe Rika , Ohki Kazuyoshi , Ojiri Hiroya 
Published: August 2022

Objective: To evaluate the parameters of support vector machine (SVM) using imaging data generated from the apparent diffusion coefficient (ADC) to differentiate between focal-type autoimmune pancreatitis (f-AIP) and pancreatic ductal adenocarcinoma (PDAC) when using SVM based on diffusion-weighted imaging. Methods: The 2D-ADCmean and texture parameters (16 texture features × [non-filter+17 filters]) were retrospectively segmented by 2 readers in 28 patients with f-AIP and 77 patients with pathologically proven PDAC. The diagnostic accuracy of the SVM model was evaluated by receiver operating characteristic curve analysis and calculation of the area under the curve (AUC). Interreader reliability was assessed by intraclass correlation coefficient (ICC). Results: The 2D-ADCmean and 3D-ADCmean were significantly lower in cases of f-AIP (1.10–1.15 × 10–3 mm2/s and 1.21–1.23× 10–3 mm2/s, respectively) vs PDAC (1.29–1.33 × 10–3 mm2/s and 1.41–1.43 × 10–3 mm2/s, respectively), with excellent and good interreader reliability, respectively (ICC = 0.909 and 0.891, respectively). Among the texture parameters, energy with exponential filtering yielded the highest AUC (Reader 1: 74.7%, Reader 2: 81.5%), with fair interreader reliability (ICC = 0.707). The non-linear SVM, a combination of 2D-ADCmean, object volume and exponential-energy showed an AUC value of 96.2% in the testing cohorts. Conclusion: Our results suggest that non-linear SVM using a combination of 2D-ADCmean, object volume, and exponential-energy may assist in differentiating f-AIP from PDAC. Advances in knowledge: The radiomics based on an apparent diffusion coefficient value may assist in differentiating f-AIP from PDAC.
Physical therapists’ use of personal protective equipment during the COVID-19 pandemic: a cross-sectional study in Saudi Arabia
Authors: Elsayed Walaa , Albagmi Faisal , Alghamdi Mohammed , Farrag Ahmed 
Published: August 2022

Background: Physical therapy (PT) services can be essential for recovery from coronavirus disease 2019 (COVID-19) infection. Maintaining an efficient healthcare service is achieved by ensuring the safety of a well-informed healthcare practitioner. This study aimed to assess the sources of knowledge, attitude, experience, and accessibility to the personal protective equipment (PPE) of the physical therapists working in Saudi Arabia. Methods: A cross-sectional study was conducted to survey on-duty PT practitioners using a web-based questionnaire. Licensed PT practitioners were invited to participate, and a sample of 424 therapists responded. The questionnaire comprised of 22 questions covering the demographic data and the following domains: sources of knowledge regarding the pandemic, experience, and attitude of the therapists during the pandemic, and accessibility to the PPE. Results: Around 83% of the participants (352) completed all the survey questions. Governmental websites were the most used source of knowledge (39%). Hand sanitization was implemented by the majority of participants (81%). Participants, mainly males and experienced therapist, were willing to treat COVID-19 patients. The COVID-19 complications of prolonged ventilation and immobilization were successfully treated by 91.2% of participants who treated positive cases. About a third of the participants were part of COVID-19 management planning teams or received training to deal with the pandemic. Most of the necessary PPE was adequately accessible during the pandemic. Conclusions: Therapists implemented the recommended hygienic practices and had no problems accessing the necessary PPE. More efforts should target therapists’ education about the social media misleading information and involving the therapists in the pandemic management planning teams.
Lessons from Indonesia, a country with highest COVID-19 mortality rate in the world: dissecting multiple aspects
Authors: Miftahussurur Muhammad , Savitri Camilia Metadea Aji , Waskito Langgeng Agung , Rezkitha Yudith Annisa Ayu , Dhamanti Inge , Indriani Diah , Suyanto Bagong , Rianda Raissa Virgy , Yamaoka Yoshio 
Published: August 2022

COVID-19 has been infecting every continent and Indonesia had suffered greatly as it ranked first for confirmed cases in Southeast Asia region with almost 100,000 deaths. We summarized Indonesian population demographic, socio-behavior, multiple government policy and public health interventions contributed to the high mortality. Although the virulence of COVID-19 strain was found to be similar as other countries, it might be inaccurate due to the low amount of sequenced genome and publicly accessible data of the virus’ strain. As Indonesia recorded higher testing number than WHO’s target, there were imbalances of testing capacity between capital cities and remote areas, hence the actual case number would be larger. The availability of healthcare facilities and skilled healthcare workers were also dispersed unequally, causing Indonesian health systems near collapsing. Moreover, individual sense of urgency and hazard of the pandemic were low, as shown by the low compliance of wearing masks and social distancing. Even though Indonesia was unprepared early in the pandemic, currently these systems are being improved. Indonesia has experienced an extensive problem in conquering the pandemic, hence, the country needed a comprehensive approach from the government, citizens, even private sectors to cease the pandemic.
Case Report: Extensive digital gangrene as a primary manifestation of late-onset systemic lupus erythematosus
Authors: Boussaid Soumaya , Ben Majdouba Marouene , Rekik Sonia , Jemmali Samia , Zouaoui Khaoula , Rahmouni Safa , Sahli Hela , Elleuch Mohamed 
Published: August 2022

Background: Digital gangrene is a rare but serious complication of systemic lupus erythematosus (SLE). It occurs usually in middle-aged patients with longer disease duration. Case: Herein we report the case of a 56-year-old man (with no history suggestive of Raynaud’s phenomenon, diabetes mellitus, smoking, trauma, infection, or chemical exposure), who presented with SLE and digital gangrene was among the first signs. He presented with a one-month history of joint pain, hair loss, photosensitivity, mouth ulcers, malar rash, dyspnea, and digital pain. Physical examination revealed painful and diffuse erythematous skin lesions in the extremities and back, as well as cyanosis in the fingers. We noted lymphocytopenia (600 cells/mm3), and an elevated C-reactive protein (15.1 mg/l) on laboratory tests. Immunological tests were positive for antinuclear antibodies (ANA) with Title 1:400. Pulmonary computed tomography revealed pulmonary fibrosis, and pulmonary function tests revealed the restrictive pulmonary disease. Diagnosis of SLE with lung involvement was retained. The immunological assessment in search of elements in favor of a vascular origin of the patient's skin lesions was negative. Treatment was initiated with 200 mg/day hydroxychloroquine. For dermal and pulmonary involvement, intravenous (IV) pulse therapy was used with methylprednisolone (1,000 mg/d for three consecutive days monthly) and cyclophosphamide (1 g/month). Calcium blocking agents were also prescribed. However, the lesions did not improve. The patient was given two infusions of rituximab (1 g) at a 14-day interval with a marked improvement of the majority of vasculitis lesions, and a partial improvement of dyspnea. Conclusions: Digital gangrene is a rare complication of late-onset SLE, especially as a primary manifestation.
Serum levels of α1-antitrypsin, interleukin-1β and interleukin-6 in Iraqi COVID-19 patients: A cross-sectional study
Authors: Abd Hayder A. , Kasim Ali A. , Shareef Laith G. 
Published: August 2022

Background: More than half of the individuals diagnosed with coronavirus disease 2019 (COVID-19) have been found to have high levels of interleukin (IL)-6. A recent report showed that more elevated serum IL-6 level predicts COVID-19 disease severity and patients’ clinical outcomes. Therefore, this study aimed to compare the serum levels of α1-antitrypsin (AAT), IL-1β, and IL-6 between COVID-19 patients and healthy individuals. Methods: During the data collection phase, 90 individuals were enrolled, 45 healthy controls, and 45 patients confirmed with COVID-19 using reverse transcription-quantitative PCR (RT-qPCR) at a specialized isolation hospital in Baghdad between November 2021 and March 2022. In this cross-sectional research, venous blood samples were taken, and serum was isolated and stored for quantitative ELISA measurements of AAT, IL-1β, and IL-6 (ELISA). IBM SPSS version 24 was used to analyze the data. Results: This study revealed a significant increase in the serum levels of AAT, IL-1β, and IL-6 in the COVID-19 patients' group compared to the healthy control group with p-values < 0.001 for each of these markers. Conclusions: AAT concentrations were higher during COVID-19; this elevation is essential during infection. IL-1β and IL-6 levels were also elevated during the infection period; however, dysregulated high levels may lead to cytokine release syndrome. Therefore, these three biomarkers can be regarded as diagnostically crucial parameters.
Effects of Triple-Pass Drum Dryer on Enzyme Activity and Quality of Forage Oats
Authors: Guo Ziwen , Li Chong , Wang Liuqing , Wang Guanghui , Wang Zhiqin , Wang Decheng 
Published: August 2022

HighlightsOats retain better quality under outlet conditions of 100°C to 110°C and 0.169 to 0.172 kg water/kg dry air.Inactivation of POD maintaining the pectin content increases the oats’ hardness.The color-changing is alleviated when higher RH and high-temperature drying.DARE-EM method can evaluate the forage oats’ overall quality.Abstract. Mechanical drying processing influences the quality changing of the materials. To investigate the differences, the qualities of mechanical dried and naturally dried forage oats were evaluated. The changes in dried oats' enzyme activity, color, texture, and nutritional value were analyzed. A combined analysis of the decision alternative ratia evaluation system (DARE) and entropy weight method (EM) were adopted to evaluate the overall qualities of oats. The results showed that the drum drying process performed better than the natural drying process. Compared with natural drying, oat grass can inactivate enzymes such as CAT and POD quickly during drum drying, shorten the time of browning reaction, and further reduce the loss of color and nutrients. Research showed that the dryer's outlet air temperature and relative humidity severely affected the quality of dried oats. The most suitable conditions were the outlet air temperature of 100°C to 110°C and humidity ratio of 0.169 to 0.172 kg water/kg dry air. Under these conditions, the dried oats’ color change was alleviated, and antioxidant enzymes were inactivated. The retention of the plant cell wall and pigment ensured the quality of oat hay. These results can provide the reference for producing high-quality forages. Keywords: Color, DARE-EM, Enzyme activity, Forage oats, Nutrient content, Triple-pass drum drying.
Comparison of a high-power 3.75  µm BaGa4Se7 OPO based on a plane-parallel resonator and an unstable resonator with a Gaussian reflectivity mirror
Authors: Liu Gaoyou , Zhang Zenan , Li Chunxiao , Meng Jun , Li Tao , Zhao Zhigang , Cong Zhenhua , Yao Jiyong , Liu Zhaojun 
Published: August 2022

Using a homemade Nd:YAG laser with a pulse repetition frequency of 300 Hz as a pump source, we demonstrated a tunable

B
a
G
a

4

S
e

7

(BGSe) optical parametric oscillator (OPO). Wavelength-tuning ranges of 1.42–1.59 µm and 3.21–4.22 µm were realized, and a maximum average output power of 1.03 W at 3746 nm was achieved in a plane-parallel resonator. To date, this is the highest output power at around 4 µm obtained from a BGSe OPO pumped by a 1 µm laser, to our knowledge. Moreover, the BGSe OPO employing a plano–convex Gaussian reflectivity mirror (GRM) as an output coupler (OC) was demonstrated for the first time, to our knowledge. At the same pump power, the corresponding output power and

M
2

value of the idler at 3746 nm were 0.86 W and 10.2 (

x

direction) and 11.6 (

y

direction), respectively. The results indicate that the beam quality factor

M
2

of the idler has an over 30% improvement in comparison with the BGSe OPO based on a conventional flat OC of a plane-parallel resonator. Limited by the beam quality of the pump source, there is little room for improvement in the beam quality of the BGSe OPO with a GRM OC, which could be improved in the future by optimizing the pump beam.
Transparent organic photodiodes for high-detectivity CMOS image sensors
Authors: Park Sungjun , Lim Younhee , Heo Chul-Joon , Yun Sungyoung , Leem Dong-Seok , Kim Sunghan , Choi Byoungki , Park Kyung-Bae 
Published: August 2022

The demand for high-definition complementary metal-oxide–semiconductor
(CMOS) image sensors has increased considerably over the past few
years in industry as well as in academia. Here we propose transparent
green-sensitive organic photodetectors (TG-OPDs) with both
dark-current-based high detectivity (over

10

14

c
m

H
z

1

/

2

W

−
1

at a wavelength of 550 nm under 3 V)
and high responsivity (

0.34

A

W

−
1

under 3 V) for organic–silicon hybrid
CMOS image sensors. A

b
a
t
h
o
c
u
p
r
o
i
n
e

:

C

60

electron-transporting layer provided
the fabricated TG-OPDs with a minimal junction resistivity, smooth
morphology, and desirable energy level modulation, resulting in
exceptional light sensitivity, a low dark current (below

10

−
11

A

c
m

−
2

), and a high rectification ratio
spanning 10 orders of magnitude. The TG-OPDs had high-temperature
endurance (up to 150°C for 2 h) and operational stability under
intense heat (above 85°C) for 50 d. We expect this performance to
enable the industrialization of these TG-OPDs for optoelectronic
sensor applications, such as photoplethysmography, fingerprint
recognition, proximity sensing, and imaging.
Clinical criteria for Mucosal Leishmaniasis diagnosis in rural South America: A systematic literature review
Authors: Bezemer Jacob M. , Meesters Kevin , Naveda Cristhian L. , Machado Paulo R. L. , Calvopiña Manuel , Leeflang Mariska M. G. , Schallig Henk D. F. H. , de Vries Henry J. C. 
Published: August 2022

Background
Mucosal Leishmaniasis (ML), a neglected tropical disease caused by Leishmania parasites, impairs the quality of life of under-resourced populations in South America. If not treated promptly, this disease progresses to facial deformities and death. The low sensitivity of microscopy results and the unavailability of other accurate tests hamper the diagnosis. As clinical criteria are readily available in any setting, these may be combined in a syndromic algorithm, which in turn can be used as a diagnostic tool. We explore potential clinical criteria for a syndromic diagnostic algorithm for ML in rural healthcare settings in South America.

Methodology/Principal findings
The protocol for this systematic review was pre-registered in PROSPERO with the number: CRD42017074148. In patients with ML, described in case series identified through a systematic retrieval process, we explored the cumulative ML detection rates of clinical criteria. Participants: all patients with active mucosal disease from an endemic area in South America. Any original, non-treatment study was eligible, and case reports were excluded. PUBMED, EMBASE, Web of Science, SCIELO, and LILACS databases were searched without restrictions. The risk of bias was assessed with the JBI checklist for case series. We included 10 full texts describing 192 ML patients. Male gender had the highest detection rate (88%), followed by ulcer of the nasal mucosa (77%), age >15 (69%), and symptom duration >4 months (63%).

Significance
Within this selection of patients, we found that the male gender, ulcer of the nasal mucosa, age >15, and symptom duration >4 months lead to the highest detection rates. However, higher detection comes -naturally- with a higher rate of false positives as well. As we only included ML patients, this could not be verified. Therefore, the criteria that we found to be most promising should be validated in a well-designed prospective study.