bluuebunny/crossref_metadata_2025_split huggingface dataset:
High-performance inorganic metal halide perovskite transistors
Authors: Liu Ao , Zhu Huihui , Bai Sai , Reo Youjin , Zou Taoyu , Kim Myung-Gil , Noh Yong-Young 
Published: February 2022

AbstractThe p-type characteristic of solution-processed metal halide perovskite transistors means that they could be used in combination with their n-type counterparts, such as indium–gallium–zinc-oxide transistors, to create complementary metal–oxide–semiconductor-like circuits. However, the performance and stability of perovskite-based transistors do not yet match their n-type counterparts, which limit their broader application. Here we report high-performance p-channel perovskite thin-film transistors based on inorganic caesium tin triiodide semiconducting layers that have moderate hole concentrations and high Hall mobilities. The perovskite channels are formed by engineering the film composition and crystallization process using a tin-fluoride-modified caesium-iodide-rich precursor with lead substitution. The optimized transistors exhibit field-effect hole mobilities of over 50 cm2 V−1 s−1 and on/off current ratios exceeding 108, as well as high operational stability and reproducibility.
Ret kinase-mediated mechanical induction of colon stem cells by tumor growth pressure stimulates cancer progression in vivo
Authors: Nguyen Ho-Bouldoires Thanh Huong , Sollier Kévin , Zamfirov Laura , Broders-Bondon Florence , Mitrossilis Démosthène , Bermeo Sebastian , Guerin Coralie L. , Chipont Anna , Champenois Gabriel , Leclère Renaud , André Nicolas , Ranno Laurent , Michel Aude , Ménager Christine , Meseure Didier , Demené Charlie , Tanter Mickael , Fernández-Sánchez Maria Elena , Farge Emmanuel 
Published: February 2022

AbstractHow mechanical stress actively impacts the physiology and pathophysiology of cells and tissues is little investigated in vivo. The colon is constantly submitted to multi-frequency spontaneous pulsatile mechanical waves, which highest frequency functions, of 2 s period, remain poorly understood. Here we find in vivo that high frequency pulsatile mechanical stresses maintain the physiological level of mice colon stem cells (SC) through the mechanosensitive Ret kinase. When permanently stimulated by a magnetic mimicking-tumor growth analogue pressure, we find that SC levels pathologically increase and undergo mechanically induced hyperproliferation and tumorigenic transformation. To mimic the high frequency pulsatile mechanical waves, we used a generator of pulsed magnetic force stimulation in colonic tissues pre-magnetized with ultra-magnetic liposomes. We observed the pulsatile stresses using last generation ultra-wave dynamical high-resolution imaging. Finally, we find that the specific pharmacological inhibition of Ret mechanical activation induces the regression of spontaneous formation of SC, of CSC markers, and of spontaneous sporadic tumorigenesis in Apc mutated mice colons. Consistently, in human colon cancer tissues, Ret activation in epithelial cells increases with tumor grade, and partially decreases in leaking invasive carcinoma. High frequency pulsatile physiological mechanical stresses thus constitute a new niche that Ret-dependently fuels mice colon physiological SC level. This process is pathologically over-activated in the presence of permanent pressure due to the growth of tumors initiated by pre-existing genetic alteration, leading to mechanotransductive self-enhanced tumor progression in vivo, and repressed by pharmacological inhibition of Ret.
Glia fuel neurons with locally synthesized ketone bodies to sustain memory under starvation
Authors: Silva Bryon , Mantha Olivier L. , Schor Johann , Pascual Alberto , Plaçais Pierre-Yves , Pavlowsky Alice , Preat Thomas 
Published: February 2022

AbstractDuring starvation, mammalian brains can adapt their metabolism, switching from glucose to alternative peripheral fuel sources. In the Drosophila starved brain, memory formation is subject to adaptative plasticity, but whether this adaptive plasticity relies on metabolic adaptation remains unclear. Here we show that during starvation, neurons of the fly olfactory memory centre import and use ketone bodies (KBs) as an energy substrate to sustain aversive memory formation. We identify local providers within the brain, the cortex glia, that use their own lipid store to synthesize KBs before exporting them to neurons via monocarboxylate transporters. Finally, we show that the master energy sensor AMP-activated protein kinase regulates both lipid mobilization and KB export in cortex glia. Our data provide a general schema of the metabolic interactions within the brain to support memory when glucose is scarce.
Improved prediction of the vertical distribution of ground ice in Arctic-Antarctic permafrost sediments
Authors: Lacelle Denis , Fisher David A. , Verret Marjolaine , Pollard Wayne 
Published: February 2022

AbstractGlobal warming and permafrost degradation are impacting landscapes, ecosystems and the climate-carbon system. Current ground ice and geohazard maps rely on the frost susceptibility of surficial sediments, and substantial areas underestimate ice abundance. Here we use a soil environmental model to show the importance of considering unfrozen water content (dependent on sediment type, soil water chemistry, and temperature) when assessing the frost susceptibility of sediments. Our ensemble modeling of the vertical structure and evolution of ground ice for fine to coarse-grained sediments matches reasonably well with field measurements at sites from the low Arctic to the cold and hyper-arid Dry Valleys of Antarctica. Our modeling indicates a need to re-evaluate how frost-susceptible sediments are identified when mapping ice-rich permafrost landscapes and provides a framework for the development of quantitative estimates of the vertical distribution of ground ice in permafrost sediments at regional scale.
Speech Changes After Transcranial Direct Current Stimulation in Individuals Diagnosed With Parkinson's Disease
Authors: Leydon Ciara , Brooks Kaitlin , Feng Guanchao , Hsu David T. , Schwartz Guy , Fabus Renee 
Published: February 2022

Purpose:
Parkinson's disease (PD) is a progressive neurological disease that results in motor and cognitive impairments, including impaired speech production. Transcranial direct current stimulation (tDCS) is a noninvasive brain stimulation technique that shows promise in improving limb motor skills and executive function in individuals with PD. The aim of this study was to examine the impact of tDCS on speech production in individuals diagnosed with PD.

Method:
Six males, aged 65–78 years, with a diagnosis of PD, participated in a double-blinded controlled crossover study to assess the immediate effects of tDCS to the premotor cortex on speech production. Auditory–perceptual (Consensus Auditory–Perceptual Evaluation—Voice) and acoustic voice outcomes (e.g., fundamental frequency, intensity, noise-to-harmonic ratio [NHR], and speech rate) were gathered pre- and post-anodal simulation and sham conditions. Measures were compared across times and conditions.

Results:
Speech rate was below normative levels for all participants prior to tDCS. Speech rate increased significantly in conversation following stimulation but not sham conditions and exceeded normative values for two participants. NHR increased following stimulation. No significant difference in other perturbation measures, perceptual ratings, fundamental frequency, or intensity were noted.

Conclusions:
All participants completed the protocol without discomfort. The observed increase in speech rate needs to be interpreted in the context of excitation resulting from neurostimulation using tDCS.
Multifunctional fluorine‐free superhydrophobic coating with flame‐retardant, anti‐icing, anti‐corrosion, and oil–water separation properties
Authors: Li Shuyi , Xie Chuankun , Zhang Wenliang , Wei Dongsong , Zheng Zaihang , Liu Yan 
Published: February 2022

AbstractA fluorine‐free and multifunctional superhydrophobic coating (r‐MSC) was prepared by the one‐step spraying method. The coating had superhydrophobic and low‐adhesion properties with the water contact angle of 161.5° ± 1° and the sliding angle of 3.2° ± 0.5°. It could be prepared by spraying while maintaining superhydrophobic surface characteristics on any substrates. The coating owed outstanding mechanical durability and chemical stability. Moreover, the coating also possessed the ability of self‐cleaning, anti‐fouling, anti‐icing, and flame retardant ability. Importantly, the presence of multifunctional coating endowed the substrate with both water‐resistant and fireproof properties. Besides, it also showed excellent oil‐water separation ability, which presented the oil‐water separation efficiency of over 90% for different types of oils after 10 separation cycles. Furthermore, the coating could improve corrosion inhibition performance and the corrosion current density was reduced by two orders of magnitude from the polarization curve. The r‐MSC had the advantages of simple preparation, fluorine‐free, environmentally friendly and appropriate for large‐area fabrication, which could be applied to various fields.
Real time power management strategy for an all‐electric ship using a predictive control model
Authors: Wang Bo , Peng Xiuyan , Zhang Lanyong , Su Peng 
Published: February 2022

AbstractThis study proposes a power management strategy (PMS) that can efficiently and accurately address the nonlinear dynamics of ship power systems for all‐electric ships (AESs). The design of a PMS can be considered naturally in a model predictive control framework. However, the control error caused by a model mismatch is a challenge of the PMS for physical system implementation. The proposed PMS is based on a complex system‐level nonlinear model that ensures a minimum mismatch. In addition, an efficient optimization algorithm is proposed to efficiently apply the PMS. The proposed method is verified using real‐time simulations with physical systems in various scenarios. The experimental results demonstrate the superior efficiency of the proposed optimization algorithm and the accuracy of the developed PMS for physical system implementation.
Construction and validation of m6A RNA methylation regulators associated prognostic model for gastrointestinal cancer
Authors: Miao Yandong , Su Bin , Tang Xiaolong , Wang Jiangtao , Quan Wuxia , Chen Yonggang , Mi Denghai 
Published: February 2022

AbstractN6‐methyladenosine (m6A) RNA methylation is correlated with carcinogenesis and dynamically possessed through the m6A RNA methylation regulators. This paper aimed to explore 13 m6A RNA methylation regulators' role in gastrointestinal cancer (GIC) and determine the risk model and prognosis value of m6A RNA methylation regulators in GIC. We used several bioinformatics methods to identify the differential expression of m6A RNA methylation regulators in GIC, constructed a prognostic model, and carried out functional enrichment analysis. Eleven of 13 m6A RNA methylation regulators were differentially expressed in different clinicopathological characteristics of GIC, and m6A RNA methylation regulators were nearly associated with GIC. We constructed a risk model based on five m6A RNA methylation regulators (METTL3, FTO, YTHDF1, ZC3H13, and WTAP); the risk score is an independent prognosis biomarker. Moreover, the five m6A RNA methylation regulators can also forecast the 1‐, 3‐ and 5‐year overall survival through a nomogram. Furthermore, four hallmarks of oxidative phosphorylation, glycolysis, fatty acid metabolism, and cholesterol homoeostasis gene sets were significantly enriched in GIC. m6A RNA methylation regulators were related to the malignant clinicopathological characteristics of GIC and may be used for prognostic stratification and development of therapeutic strategies.
Gesundheitskompetenz von Menschen mit und ohne Behinderung und
chronischer Erkrankung in Deutschland: Ergebnisse der Studie „Gesundheit
in Deutschland Aktuell“ 2014/2015-EHIS
Authors: Rathmann Katharina , Wetzel Lorena Denise , Jordan Susanne 
Published: February 2022

Zusammenfassung
Hintergrund Menschen mit Behinderung und chronischer Erkrankung sind eine
Bevölkerungsgruppe in vulnerablen Lebenslagen, die häufig
Schwierigkeiten beim Finden, Verstehen, Beurteilen und Anwenden von
Gesundheitsinformationen aufweisen. Ziel des Beitrags ist es, die
Gesundheitskompetenz von Menschen mit doppelter Exposition (d. h.
Behinderung und chronischer Erkrankung) im Vergleich zu Menschen mit einfacher
Exposition (d. h. Behinderung oder chronischer Erkrankung) und Menschen
ohne Beeinträchtigung, zu untersuchen.
Material und Methoden Datenbasis ist der Survey „Gesundheit in
Deutschland Aktuell“ 2014/2015-EHIS. Die Stichprobe umfasst
n=21 647 Personen, mit 2875 (13,3%) Menschen mit
Behinderung und chronischer Erkrankung, 7598 Personen (35,1%) mit
Behinderung oder chronischer Erkrankung sowie 11 174 (51,6%)
Personen ohne Beeinträchtigung. Die Gesundheitskompetenz wurde mit dem
HLS-EU-Q16-Fragebogen erhoben. Es wurden uni-, bi- und multivariate Analysen
durchgeführt.
Ergebnisse 43,7% der Befragten mit Behinderung und chronischer
Erkrankung berichten sehr bzw. ziemliche Schwierigkeiten beim Umgang mit
Gesundheitsinformationen im Vergleich zu 37,7% der Personen mit
Behinderung oder chronischer Erkrankung bzw. 33,0% ohne
Beeinträchtigung. Menschen mit einer doppelten Exposition weisen eine
1,22-fach (KI: 1,10–1,35; p<0,001) und Menschen mit einer
einfachen Exposition eine 1,08-fach (KI: 1,01–1,16; p=0,031)
erhöhte Chance auf, es ziemlich bzw. sehr schwierig zu finden,
gesundheitsbezogene Informationen zu finden, verstehen, beurteilen und
anzuwenden im Vergleich zu Menschen ohne Beeinträchtigung.
Schlussfolgerung Die Ergebnisse verdeutlichen einen Gradienten in der
Gesundheitskompetenz zu Ungunsten von Menschen mit Beeinträchtigung. Die
Gesundheitskompetenz von Menschen mit Behinderung und/oder chronischen
Erkrankung sollte zielgruppenspezifisch gefördert werden, um ihre
Gesundheit, Teilhabe sowie die Qualität, Effizienz und den Abbau von
Barrieren beim Zugang zur Gesundheitsversorgung zu unterstützen.
Decipher the inhibitory potential of phytocompounds from Leptadenia reticulata on dopamine D2 receptor to enhance prolactin secretion
Authors: Sharma Roshan Kumar , Jalalpure Sunil S , Chouhan Mahendra Kumar , Deshpande Sanjay , Acharya Rabinarayan , Hegde Satisha 
Published: February 2022

AbstractDopamine is secreted by the hypothalamus, which inhibits the proliferation and effectiveness of lactotroph cells that release prolactin via dopamine D2 receptor (D2R). D2R activation inhibits lactotroph cell prolactin synthesis and regulates prolactin gene expression. Although, commercial medications are available for hypogalactia and agalactia, various plant sources significantly alleviate these problems. Leptadenia reticulata (Jivanti) is one of the important medicinal plants often consumed by nursing mothers to improve breast milk production. However, mechanism and chemical constituents involved in the inhibition of D2R by Jivanti is unclear. Therefore, in this study the phytocompounds reported from Jivanti were used for in-silico analysis to predict D2R inhibitory potential. The binding affinity value of campesterol and β-sitosterol (− 10.1 and −10.0 kcal/mol) with D2R has high revealed by molecular docking and stable interaction reveled by molecular dynamics simulation. Thus, these lead compounds could exert more D2R inhibitory activity resulting into prolactin release, which may lead to an increase in breast milk production. Although all selected compounds had fine permeation, non-toxic, and non-carcinogenic characteristics predicted by ADMET, campesterol had good solubility, absorption characteristics compared to other. Therefore, Jivanti, which is traditionally known medicinal plant, could be explored as a medication candidate to boost breast milk production.
Carcass characteristics, colour and eating quality of beef from late maturing suckler bulls finished at pasture with or without concentrate supplementation or indoors on a high concentrate ration
Authors: Moloney A. P. , O’Riordan E. G. , McGee M. , O’Sullivan M. G. , Kerry J. P. , Wilson S. S. , Monahan F. J. , Kelly A. K. , McMenamin K. , Moran L. 
Published: February 2022

Context Their growth and feed efficiency advantages make bull beef production systems attractive alternatives for producers of beef from steers. Finishing bulls from pasture is less costly and would allow bull beef to be marketed as ‘grass-fed’. However, such carcasses may not meet the minimum fatness classification of 6.0 (on a 15-point scale) required for some beef markets. This is based in part on a perception that meat from bulls with a lower fatness classification per se is inferior in some quality characteristics. Aim To determine the comparative carcass and beef quality characteristics of grass-fed and concentrate-fed bulls. Methods Spring-born, late-maturing breed suckler bull weanlings sourced from commercial beef suckler herds were assigned after their first winter to one of four experimental treatments until they were slaughtered 199 days later at an average age of 19.3 months. Treatments were: (1) grazed grass for 98 days (G), then housed and offered concentrates + grass silage ad libitum indoors for 101 days (G-HC), (2) grazed grass supplemented with concentrates (target 500 g/kg total daily dietary dry matter intake) for 199 days (GC-GC), (3) grazed grass for 98 days, then supplemented with concentrates (target 500 g/kg total daily dietary dry matter intake) at pasture for 101 days (G-GC), or (4) grazed grass only for 199 days (G-G). After slaughter, carcasses were weighed and graded for conformation and fatness. After 72 h, longissimus thoracis (LT) colour was measured. After 14 days ageing, LT was assessed for eating quality characteristics. Results Carcass weight averaged 399, 381, 374 and 361 kg for G-HC, GC-GC, G-GC and G-G bulls, respectively. Corresponding carcass fat scores were 7.5, 5.1, 5.5 and 4.8, only G-HC exceeded the minimum fat score specification. Meat from bulls finished at pasture was less red but the differences were small. After ageing for 14 days at 2°C, there was no difference in tenderness, flavour or acceptability between striploin steaks from any of the treatment groups. Conclusions Although none of the grazing groups achieved the current market specification for carcass fat score, this was not reflected in inferior eating quality. Implications Carcass fat score is a poor indicator of the eating quality of grass-fed bull beef. There is therefore an opportunity for suckler bull producers to access the growing market for ‘grass-fed’ beef.
The association of end‐spurt behaviour with seasonal best time in long‐distance freestyle pool swimming
Authors: Neuloh Joshua E. , Venhorst Andreas , Forster Sabrina , Mauger Alexis R. , Meyer Tim 
Published: February 2022

ABSTRACTTo analyse the association of seasonal best time, distance and different performance levels with end‐spurt behaviour in one swimming season. Race results in 800 and 1500 m pool freestyle swimming in the season 2018/2019 including 14,930 races and 2650 swimmers were obtained. The end‐spurt for each race was determined by means of an End‐Spurt Indicator (ESI). Subsequently, ESI was used as a dependent variable and influences were analysed using a linear mixed model with fixed effects for seasonal best time, distance, and performance level amongst others. In the 800 and 1500 m races swimmers showed a mean ESI of 2.08 (95% CI: 2.02–2.13) and 3.68 (95% CI: 3.59–3.76), respectively. There was a significant association between seasonal best time and ESI, with a better seasonal best time showing a greater ESI (F = 70.5, P < .001, f2 = 0.04). A significant effect on greater ESI was also observed for longer distance (F = 1067.5, P < .001, f2 = 0.06) and higher performance level (F = 91.1, P < .001, f2 = 0.02). Elite swimmers had a mean ESI of 5.47 (95% CI: 4.91–6.03), sub‐elite swimmers of 3.74 (95% CI: 3.53–3.95) and competitive swimmers of 2.41 (95% CI: 2.37–2.46). A more pronounced end‐spurt is associated with seasonal best time in long‐distance pool swimming, higher performance level of the swimmer and longer race distance.
Land cover change and multiple remotely sensed datasets consistency in China
Authors: Wang Hui , Cai Liping , Wen Xiaojin , Fan Donglin , Wang Yuejun 
Published: February 2022

Abstract

Introduction
Although numerous land cover datasets can act as references for understanding land cover change in China, the inconsistencies between the datasets can also provide understanding. Previous studies on the consistency between land cover datasets have mostly focused on land cover type consistencies and have ignored data consistencies in land cover change.

Outcomes
Therefore, we aim to analyse the consistencies in land cover changes through likelihood assessment methods. We compared the spatiotemporal changes in forest, grassland, cropland, and bare land in the Climate Change Initiative land cover dataset (CCI-LC), Moderate-resolution Resolution Imaging Spectroradiometer land cover dataset (MCD12Q1), China’s National Land Use and Cover Change (CNLUCC), Globeland30 and Global Land Cover Fine Surface Covering 30 (GLC-FCS30) datasets in 2010. The results showed that the percentages and changes in each land cover type in MCD12Q1 were different from those in the other datasets.

Discussion
For example, the proportion of grassland in MCD12Q1 was the highest, reaching 48.04%. The places with high consistency were the places where the land cover types were concentrated, and the bare land had the highest consistency. However, the consistency of China’s land cover change was quite low, and the percentage of low consistency was more than 87% from 2000-2018. Comparison of the data with the global artificial impervious area (GAIA) and Hansen-Global Forest Change (Hansen-GFC) datasets showed that the percentage of high construction gain consistency (38.83%) was higher than the forest change consistency, and the percentage forest loss high consistency (8.85%) was lower than the forest gain high consistency (12.76%).

Conclusion
The results not only provide a basis for the use of land cover datasets but also give a clearer understanding of the pattern of land cover changes.
Spin–orbit gravitational locking—an effective potential approach
Authors: Clouse Christopher , Ferroglia Andrea , Fiolhais Miguel C N 
Published: February 2022

Abstract
The objective of this paper is to study the tidally locked 3:2 spin–orbit resonance of Mercury around the Sun. In order to achieve this goal, the effective potential energy that determines the spinning motion of an ellipsoidal planet around its axis is considered. By studying the rotational potential energy of an ellipsoidal planet orbiting a spherical star on an elliptic orbit with fixed eccentricity and semi-major axis, it is shown that the system presents an infinite number of metastable equilibrium configurations. These states correspond to local minima of the rotational potential energy averaged over an orbit, where the ratio between the rotational period of the planet around its axis and the revolution period around the star is fixed. The configurations in which this ratio is an integer or an half integer are of particular interest. Among these configurations, the deepest minimum in the average potential energy corresponds to a situation where the rotational and orbital motion of the planet are synchronous, and the system is tidally locked. The next-to-the deepest minimum corresponds to the case in which the planet rotates three times around its axis in the time that it needs to complete two orbits around the Sun. The latter is indeed the case that describes Mercury’s motion. The method discussed in this work allows one to identify the integer and half-integer ratios that correspond to spin–orbit resonances and to describe the motion of the planet in the resonant orbit.