bluuebunny/crossref_metadata_2025_split huggingface dataset:
The influence of school principal supervision, motivation, and work satisfaction on teachers’ performance
Authors: Suriagiri Suriagiri , Akrim A. , Norhapizah Norhapizah 
Published: August 2022

This paper aims to explore the relationship between school principal supervision, motivation and work satisfaction vis-a-vis teacher’s performance in Indonesian education system. The accountability and quality assurance mechanism developed by the Indonesian government in the form of principal supervision works and directly impacts teacher’s performance. It binds teacher to follow predefined patterns and if they deviate, they can face penalties. Moreover, motivation is linked with choice of profession and excellence in profession. Motivation can be drawn from monetary benefits, power associated with profession and prestige, or social status and respect. It has been observed that teachers are usually demotivated by lack of monetary and social benefits. It has been noted that teacher’s performance enhances dramatically when they’=are not under undue pressure and are given their due liberty. Performance also increases when work place environment is suitable for nurturing the professional and personal skills of teachers. Furthermore, teachers are well motivated when they receive approval from their supervisors and when their colleagues were more cooperative. This also compensates for the lower monetary benefits and prestige associated with teaching. Data is collected from teaching sector of Indonesia via questionnaires. This study will help in ensuring a bright educational future for next generation in Indonesia.

Keywords: Principal Supervision, Work Satisfaction, Motivation, Teacher Performance
Quality Assessment of Seven Brands of Albendazole Tablets Marketed in Yemen
Authors: Othman Gamil Q. 
Published: August 2022

Objective: To assess certain quality control parameters for seven brands of albendazole tablets obtained from different retail pharmacies.
Methods: The physicochemical properties and active ingredientsofseven randomly selectedbrands of albendazole tablets were assessed weight uniformity, hardness, friability, disintegration and dissolution
Results: All seven albendazole brands met the British Pharmacopeia (BP) quality control standards of weight uniformity, friability and the active ingredient content. Five brands met the BP disintegration criterion,whereas only two brands complied with the BP quality control parameters of the dissolution specifications.
Conclusions: Out of the seven brands of albendazole (400 mg) tablets, only two fulfillthe BP quality control standards and show physicochemicalquivalence. This emphasizes the need for regular assessment of marketed drugs to assure equivalenceof these drugs to their innovators.
Berberine Chloride and Hyperthermia Promote Osterix Expression and Suppress Cell Cycle Genes in Osteosarcoma Cells
Authors: Nashiry Mohammed Ali , AL-Khateeb Alyaa R Rajih , Froemming Gabriele 
Published: August 2022

Objectives: The aim of the current study was to investigate the effects of berberine chloride and various heat conditions on the gene expression of Osterix, RUNX-2, RANKL, CDK2, CDK4, IL-6 and IL-11.
Methods: Six groups of cells were treated with hyperthermia for 1 h: Two groups at mild, two at moderate and two at severe hyperthermia (39, 43 and 45°C respectively). Berberine chloride (80 µg/mL) was selected for treating one group of mild, moderate and severe hyperthermia (combination). All treated groups were recovered at 37°C for 24 h. Another exposure for hyperthermia (1 h) and recovery for 3 h at 37°C were applied.
Results: The expression of Osterix was highly upregulated in all groups except in the severe hyperthermia and mild hyperthermia with berberine groups. Only the mild hyperthermia without berberine induced a slight increase in the expression of RUNX2, whereas severe hyperthermia alone suppressed the levels on a significant manner. Berberine alone was more effective in significantly up-regulating RANKL expression. On the other hand, CDK2 mRNA was downregulated in all groups. CDK4 showed a similar regulation in the mild hyperthermia group with control, but the expression was downregulated in the other groups, especially in severe hyperthermia the expression was significantly downregulated (p<0.5). IL-6 was upregulated highly and significantly in the group of berberine and all groups of combinations, whereas mild and moderate hyperthermia stimulated significant expression of IL-11 mRNA.
Conclusion: These results suggest that hyperthermia and berberine chloride can promote osteosarcoma cells differentiation and arrest cell-cycle.
Symptom-driven inhaled corticosteroid/long-acting beta-agonist therapy for adult patients with asthma who are non-adherent to daily maintenance inhalers: a study protocol for a pragmatic randomized-controlled trial
Authors: Krings James , Wojcik Kaitlyn M. , Chen Vanessa , Sekhar Tejas C. , Harris Kelly , Zulich Abigail , Sumino Kaharu , Brownson Ross , Lenze Eric , Castro Mario 
Published: August 2022

Abstract
BACKGROUNDWhile inhaled corticosteroids (ICS) are considered the essential foundation of most asthma therapy, ICS inhaler nonadherence is a notoriously common problem and a significant cause of asthma-related morbidity. Partially acknowledging the problem of nonadherence, international organizations recently made paradigm-shifting recommendations that all patients with mild-to-moderate persistent asthma be considered for symptom-driven ICScontaining inhalers rather than relying on adherence to traditional maintenance ICS inhalers and symptom-driven short-acting beta-agonists (SABA). With this new approach, asthma patients are at least exposed to the important anti-inflammatory effects of ICS-containing inhalers when their symptom reliever inhaler is deployed due to acute symptoms. METHODSThis study will ( Part 1 ) complete a pragmatic randomized-controlled trial to evaluate if an inhaler strategy that utilizes symptom-driven ICS inhalers is particularly beneficial in maintenance ICS inhaler non-adherent asthma patients, and ( Part 2 ) use a dissemination and implementation (D&I) science conceptual framework to better understand patients’ and providers’ views of inhaler nonadherence. This study, which will have an option of taking place entirely remotely, will use a Food and Drug Administration (FDA)-approved electronic sensor (Hailie® sensor) to monitor inhaler adherence and includes semi-structured interviews guided by the Consolidated Framework for Implementation Research (CFIR). DISCUSSIONThis study is assessing the problem of nonadherence using a D&I implementation science research lens while testing a new inhaler approach to potentially ameliorate the detrimental consequences of maintenance inhaler nonadherence. We hypothesize that the use of a symptom-driven ICS/LABA management strategy, as compared to traditional maintenance ICS treatment and symptom-driven SABA, will lead to improved adherence to an asthma treatment strategy, decreased asthma-related morbidity, less cumulative ICS exposure, and greater patient satisfaction with an inhaler approach. TRIAL REGISTRATIONThe study was registered via ClinicalTrials.gov on November 8, 2021. The registration number is NCT05111262.
Interference Patterns Within a Circular Boundary
Authors: Korula Aswan 
Published: August 2022

Abstract
In this paper we conduct a simple experiment wherein we create a wave within a circular container and analyse the interference patterns generated by the reflections from the boundary. In doing so we observe constructive interference in positions where our current wave theory predicts noise. This peculiar result demonstrates that in the particular situation presented here, the velocities of a wave before and after reflection from a solid boundary, are unequal.
Efficacy of computer- and/or internet-based cognitive-behavioral guided self-management for depression in adults and adolescents: a systematic review and meta-analysis of randomized controlled trials
Authors: Mamukashvili-Delau Megi , Koburger Nicole , Dietrich Sandra , Rummel-Kluge Christine 
Published: August 2022

Abstract
Background
Depression is a worldwide disease. Studies show that the rate of depression during the COVID-19 breakout seems to have considerably increased. CBT-based self-help treatment allows patients with mild to moderate depression symptoms to improve their depression or to bridge the waiting- or pandemic period until they receive further clinical treatment.
Objective
This systematic review and meta-analysis aims to explore the efficacy and acceptability of computer-delivered and/or internet-based CBT self-help interventions with minimal guidance (up to 10 minutes) for depression. In addition, comparing the effectiveness of treatment by the type of minimal guidance: (1) by e-mail, (2) by telephone calls, (3) by e-mail and telephone together, or (4) face-to-face in reducing depression symptoms at post-treatment was the second aim.
Methods
The Cochrane depression, anxiety, and neurosis review group’s specialized register electronic searches, grey literature, reference lists and correspondence were used to search for published and unpublished RCTs that reported efficacy of computer- and/or internet-based CBT self-help treatments for depression with minimal guidance up to 10 minutes per week. Methodological quality of included studies was evaluated with Cochrane Collaboration tools for assessing risk of bias. The meta-analysis was accomplished using the RevMen software.
Results
In total, 2620 study abstracts were checked for eligibility. Out of these, 17 studies (18 samples) with a total of 3134 participants were included. The results showed that concerning efficacy, the treatment group is superior to the control group with a medium to large effect size of 0.60. Also, treatment groups with combined guidance by e-mail and telephone calls together had greater effects (SMD − 0.74) than groups with other types of minimal guidance (guided by e-mail SMD − 0.63; guided face to-face SMD – 0.66; guided by telephone calls SMD − 0.33). Moreover, there were higher drop-out rates in the treatment condition (RR 1.35) than in the control groups.
Conclusions
The results of this meta-analysis support the efficacy of computer- and/or internet-based CBT self-help programs with minimal weekly guidance for improving depression symptoms at post-treatment for adults and adolescents.
Treatment Resistance to Melanoma Therapeutics on a Single Cell Level
Authors: Yao Lijun , Krasnick Bradley , Bi Ye , Sethuraman Sunantha , Weerasinghe Amila , Wetzel Chris , Gao Qingsong , Jacqueline Mudd , Wyczalkowski Matthew , Wendl Michael , Goedegebuure Simon , Ding Li , Fields Ryan 
Published: August 2022

Abstract
Therapy targeting the BRAF-MEK cascade created a treatment revolution for patients with BRAF mutant advanced melanoma. Unfortunately, 80% patients treated will progress by 5 years follow-up. Thus, it is imperative we study mechanisms of melanoma progression and therapeutic resistance. We created a scRNA (single cell RNA) atlas of 128,230 cells from 18 tumors across the treatment spectrum, discovering melanoma cells clustered strongly by transcriptome profiles of patients of origins. Our cell-level investigation revealed gains of 1q and 7q as likely early clonal events in metastatic melanomas. By comparing patient tumors and their derivative cell lines, we observed that PD1 responsive tumor fraction disappears when cells are propagated in vitro. We further established three anti-BRAF-MEK treatment resistant cell lines using three BRAF mutant tumors. ALDOA and PGK1 were found to be highly expressed in treatment resistant cell populations and metformin was effective in targeting the resistant cells. Our study suggests that the investigation of patient tumors and their derivative lines is essential for understanding disease progression, treatment response and resistance.
Prefrontal engrams of long-term fear memory perpetuate pain perception
Authors: Stegemann Alina , Liu Sheng , Romero Oscar Retana , Oswald Manfred , Han Yechao , Beretta Carlo , Tan Linette , Wisden William , Gräff Johannes , Kuner Rohini 
Published: August 2022

Abstract
A painful episode can lead to life-long increase in an individual’s experience of pain; however, mechanisms for such long-lasting modulation are not well understood. Fearful anticipation of imminent pain has been suggested to play a role1, 2, but the neurobiological underpinnings are unclear, since fear can paradoxically both suppress and enhance pain2,3. Here, we show in mice that in contrast to acute or innate fear, chronic fear memory encoded and stored in neuronal engrams in the prefrontal cortex is both necessary and sufficient to define whether a painful episode profoundly shapes the experience of ongoing pain at a later point in life. Furthermore, in conditions of inflammatory and neuropathic pain, prefrontal engrams for fear memory expand to encompass neurons representing nociception and tactile sensation, leading to pronounced changes in prefrontal connectivity to key brain areas. In contrast, silencing prefrontal fear memory engrams reverses chronically established hyperalgesia and allodynia. These results reveal that a discrete subset of prefrontal cortical neurons can account for the debilitating comorbidity of long-term fear and chronic pain and show that attenuating the fear memory of pain can alleviate chronic pain itself.
Psychological measures of stress and associated biomarkers in breast cancer survivors on aromatase inhibitors
Authors: Nair Chandini , Blaes Anne H. , Everson-Rose Susan , Jewett Patricia , Wolf Jack , Zordoky Beshay 
Published: August 2022

Abstract
The use of aromatase inhibitors (AIs) is associated with higher rates of cardiovascular events and lower endothelial function in breast cancer survivors. Psychosocial stress is associated with higher levels of inflammatory and aging markers, and lower endothelial function in otherwise healthy subjects. Given these associations among breast cancers survivors on AIs are not well defined, a cross-sectional study of 31 breast cancer survivors on AIs was performed to assess the associations between scores of psychosocial stress (PHQ-9, PSS, and GAD-7 questionnaires) and markers of inflammation, aging, and endothelial function. Endothelial function was assessed using the EndoPAT2000 system. Breast cancer patients on AIs demonstrate a positive correlation between psychosocial stress scores and inflammatory markers C reactive protein, IL-6, and ICAM-1. There was no significant association between psychosocial stress cores and either endothelial function or gene expression of the aging biomarker p16INK4a. Psychosocial stress is associated with higher inflammatory markers in breast cancer survivors on AIs. The lack of association between psychosocial stress and either endothelial function or aging biomarkers may be due to the already low endothelial function and accelerated aging in our cohort of breast cancer survivors on AIs. Further work is needed to understand this association.
Degree of apoptosis in bronchoalveolar lavage fluid correspond to the severity of brain injury
Authors: Siwicka-Gieroba Dorota , Terpilowska Sylwia , Robba Chiara , Kotfis Katarzyna , Wojcik-Zaluska Alicja , Bielacz Magdalena , Dabrowski Wojciech 
Published: August 2022

Abstract
Objectives: The mechanism of acute brain injury initiates a cascade of consequences which can directly cause lung damage, and this can contribute to poor neurological outcomes. The aim of this study was to evaluate activation of different apoptotic pathways in the bronchoalveolar lavage fluid (BALF) in patients after severe brain injury and to correlate them with selected clinical variables and mortality.Methods: Patients with brain injury undergoing BALF were included in the study. BALF samples were collected within the first 6-8 hours after traumatic brain injury (A) and at days 3 (B) and 7 (C) after admission to the ICU. Changes in the BALF nuclear-encoded protein (Bax), apoptotic regulatory protein (Bcl-2), pro-apoptotic protein (p53) and its upregulated modulator (PUMA), apoptotic protease factor 1 (APAF-1), Bcl-2 associated agonist of cell death (BAD) and caspase-activated DNase (CAD) were analysed to assess the degree of apoptosis. These values were correlated with the Rotterdam computed tomography (CT) score, the Glasgow Coma Score and 28-day mortality. Results: We found a significant increase in the concentration of selected apoptotic factors at admission (A), at days 3 (B) and 7 (C) after brain injury compared to baseline level A (p<0.001 respectively). That activation of selected apoptotic factors was significantly correlated with the severity of the injury and mortality.Conclusions: Activation of different apoptotic pathways seems to be an important process occurring in the lungs of patients in the early phases after severe brain trauma. Activation of apoptosis in the lungs correlates with the severity of brain injury.
Novel Hypocrealean Fungi from Rhizophoraceae, Neocosmospora mangrovei sp. nov. and Neocosmospora ceriopis sp. nov., and their Antifungal Activity against Anthracnose Pathogen Colletotrichum spp.
Authors: Brooks Siraprapa , Klomchit Anthikan , Calabon Mark Seasat , Chomnunti Putarak , Worabandit Sompradtana 
Published: August 2022

Abstract
Neocosmospora is a fungus genus that contains saprobes, endophytes, and pathogens in the family Nectriaceae. Prior to this study, 113 morphological species belonging to this genus have been described and published. In this study, we reported two new species of fungus, Neocosmospora mangrovei (MFLUCC 17–0253; MFLUCC 17–0257) and N. ceriopis (MFLUCC 17–0259) that were isolated from the mangrove habitats in the Southern part of Thailand. Phylogenetic analyses of the combined ITS, EF-1α, RPB2, and LSU regions showed that the new species clustered within the Neocosmospora clade with strong statistical support. Detailed descriptions and illustrations, pairwise homoplasy index (PHI) test, and a phylogenetic tree showing the position of both new species are provided. In addition, both new species showed the potential to be used as biocontrol agents against Colletotrichum spp. The N. mangrovei, MFLUCC 17–0253 exhibited strong antifungal activity against C. truncatum, MFLUCC CG-0064 e.g., 100% of mycelium growth inhibition, 90.83% inhibition of spore germination, and 100% reduction hyphae expansion. The N. ceriopis MFLUCC 17–0259 exhibited antifungal activity against C. acutatum, MFLUCC CC-0036 e.g., 69.39% of mycelium growth inhibition, 79.39% inhibition of spore germination, and 96.42% reduction hyphae expansion. Overall, these findings suggested novel species of Neocosmospora that had the capacity to produce various classes of biometabolites including 2,3-hydro-5-hydroxy-8-methoxy-2,4-dimethylnapthol-[1,2-b]-furan-6,9-dione, 2-methoxy-6-methyl-7-acetonyl-8-hydroxy-1,4-maphthalenedione, 5,8-dihydroxy-7-acetonyl-1,4-naphthalenedione, anhydrojavanicin, and fusarnaphthoquinones that can provide an antimicrobial activity that could have the potential in playing a big role in treating anthracnose disease.
Concentration, distribution and biomagnification of novel brominated flame retardant in grassland food chain and sheep from Inner Mongolia, China
Authors: chen Wenming , Bu Te , Li Tianwei , Bao Junsong , Wang Ying , Hu Jicheng , Jin Jun 
Published: August 2022

Abstract
Novel brominated flame retardants (NBFRs) are of great concern in the past few years due to their ubiquitousness in the environment and potential bioconcentration characteristics. This study takes Xilingol grassland in Inner Mongolia as the research area to analyze the pollution characteristics of NBFRs (pTBX, HBB, PBT, PBBz and PBEB) in grassland food chain. pTBX was more likely to be biomagnified in the food chain of amphibians, reptiles and birds, while PBT and HBB were more likely to be biomagnified in the food chain of mammals. This may be because these animals have the different diet and metabolic patterns. According to the concentration distribution of NBFRs in sheep organs and tissues, PBT, HBB and PBBz were easy to be bioaccumulated in sheep. The biomagnification effect of sheep adipose tissue and internal organs on NBFRs was inconsistent, so the biomagnification of chemicals in organisms cannot be determined only by the biomagnification of adipose tissue.
Risk and prognostic nomograms for colorectal adenocarcinoma with liver metastasis: a population-based study
Authors: WU ICHING , Huang Sai hong , Ouyang Peng , CHEN BING YI , Yiu Wingkeung , Bao Zhen , Gong Jin , Li Dengsheng 
Published: August 2022

Abstract
Purpose: The purpose of this research was to investigate the prevalence, risk, and prognostic factors associated with liver metastasis (LM) in colorectal adenocarcinoma and to develop a nomogram for predicting LM incidence and prognosis.Methods: The Surveillance, Epidemiology, and End Results (SEER) database was used to collect data from patients diagnosed with colorectal adenocarcinoma with liver metastases between 2010 and 2015. We used univariate and LASSO-multivariate logistic regression analyses to identify independent risk factors for LM in colorectal adenocarcinoma patients, and we used univariate and LASSO-multivariate Cox proportional hazards regression analyses to identify independent prognostic factors for colorectal adenocarcinoma with LM. We then made two new nomograms, and the results were checked out by receiver operating characteristic (ROC) curves, calibration curves, and decision curves (DCA).Result: There were 38,941 patients with colorectal adenocarcinoma included in the study, and 4,866 individuals were diagnosed with LM. The age, T, N, tumor size, chemotherapy, radiation, perineural invasion, surgery, and CEA level are all independent risk factors for LM in patients with colorectal adenocarcinoma. The age, grade, tumor size, chemotherapy, T stage, CEA level, marital status, and surgery are all independent prognostic variables for colorectal adenocarcinoma patients with LM. ROC curves, calibration, DCA, and Kaplan–Meier (K-M) survival curves in the training, validation, and expanded testing sets indicated that two nomograms may accurately predict the incidence and prognosis of LM in patients with colorectal adenocarcinoma.Conclusion: LM is quite common in people with colorectal adenocarcinoma. A nomogram based on risk and prognostic indicators for LM was shown to be effective at estimating the probability of LM incidence and prognosis.
Optimization of the Photocatalytic Oxidation Process in Toluene Removal from Air
Authors: Khoshpasand Fatemeh , Nikpay Ahmad , keshavarz Mehrdad 
Published: August 2022

Abstract
The present study examines using photocatalytic reaction system along with TiO 2 particles coated on stainless steel webnet to study direct conversion of toluene using a new design. The study was carried out using UV radiation in a dynamic concentrator system. SEM and XRD analyses were performed to characterize prepared catalysts. Here, the aim was to employ photocatalytic oxidation (PCO) to optimize removal efficiency and elimination capacity using response surface methodology (RSM). To this end, initial concentration and flow rate were selected as independent variables. High removal efficiency and elimination capacity were realized using optimal settings. The findings indicated that PCO process with a new design other than RSM was an option to treat air pollution containing volatile organic compounds.