bluuebunny/crossref_metadata_2025_split huggingface dataset:
Intermediate moisture date (Phoenix dactylifera L.) based dessert with natural sugars: Phytonutritional profile, characterization, sensory quality, and shelf‐life studies
Authors: Singh Veerpal , Aggarwal Poonam , Kaur Sukhpreet , Kaur Navjot 
Published: September 2022

AbstractThe present study aimed at preparing date‐based dessert in which milk solids were replaced by date paste at 50% to 70% levels to enhance the quality of formulated dessert. Developed formulations were found rich in natural sugars, bioactive constituents, and minerals which were further confirmed using inductively coupled plasma atomic emission spectroscopy. The effect of storage on quality of selected product (50% date pulp and 50% milk solids) under room (25 ± 2°C) and refrigerated (4 ± 2°C) temperatures was studied. The moisture content, water activity, total and reducing sugars and bioactive constituents decreased significantly (p < .05) while titratable acidity, free fatty acids, antioxidant activity, hardness of texture, and yeast and mold count increased with advancement of storage at both temperatures. Except moisture, the extent of quality changes was rapid during room temperature storage. Developed product was shelf stable up to 21 days under room temperature and up to 28 days under refrigeration conditions, respectively.Novelty impact statementThe developed date‐based dessert with enhanced functionality and shelf stability had improved mineral profile, bioactive constituents and antioxidant activity compared to control (traditional milk‐based dessert). Shelf life of the date‐based dessert increased manifolds (from 4 to 21 days) compared to control at room temperature. The developed nutritious date dessert can serve as a healthy sweet meal for people who cannot resist sweets after meals.
Variation in amino acid profiles of selected Sri Lankan rice varieties induced by milling
Authors: Liyanaarachchi Gigummaduwe Vimarshi Vathsala , Mahanama Kariyawasam R. R. , Somasiri Sudarshana , Punyasiri Nimal , Gunawardhana Katudeni Vidanelage Tharaka , Kottawa‐Arachchi Jeevan Dananjaya 
Published: September 2022

AbstractStudy presents the variation in free amino acids (FAAs) and total AAs in rice at different milling degrees. Two rice cultivars; Pachchaperumal and Bg 406 were subjected to three (4%, 7%, 12%) degrees of milling, and the variations in AA composition of milled rice and resulting bran were studied. Milling caused significant (p < .05) reduction (5.7%–40.0%) of AAs in rice. Milling accounted for an increase in density of FAAs with sweet and sour taste in rice while reducing FAAs with bitter taste. Parboiling unequivocally aided the retention of AAs in rice upon milling. A variety‐specific distribution of AAs was observed inside the rice grain. Despite the reduction in AAs upon milling, the nutrient density, which is the ratio between the essential to nonessential AAs was not reduced in rice. Rice bran contained nutritional gamma amino butyric acid (GABA) (19.6%–29.1%) and essential AAs (35.7%–38.8%).Novelty impact statementMilling is a post harvesting technique used in the production of rice that improves the physical properties of rice, which are desired by the consumers that include whiteness, translucency and sensory properties as well as the storage stability. The amino acid content in rice is significantly reduced with the increase in milling degree. However, milling increases the ratio between the sum of FAAs with sweet and sour taste to, sum of free amino acids with bitter taste, which could be attributed to one of the factors leading to the enhanced sensory quality observed with the well‐milled rice. Parboiling enables the retention of nutritionally and functionally important amino acids that include essential amino acids and gamma amino butyric acid (GABA) during the milling process.
Nitrogen starvation induces genome‐wide activation of transposable elements in Arabidopsis
Authors: Wang Yue , Liu Yi , Qu Shaofeng , Liang Wenjie , Sun Linhua , Ci Dong , Ren Zhitong , Fan Liu‐Min , Qian Weiqiang 
Published: September 2022

AbstractNitrogen (N) availability is a major limiting factor for plant growth and agricultural productivity. Although the gene regulation network in response to N starvation has been extensively studied, it remains unknown whether N starvation has an impact on the activity of transposable elements (TEs). Here, we report that TEs can be transcriptionally activated in Arabidopsis under N starvation conditions. Through genetic screening of idm1‐14 suppressors, we cloned GLU1, which encodes a glutamate synthase that catalyzes the synthesis of glutamate in the primary N assimilation pathway. We found that glutamate synthase 1 (GLU1) and its functional homologs GLU2 and glutamate transport 1 (GLT1) are redundantly required for TE silencing, suggesting that N metabolism can regulate TE activity. Transcriptome and methylome analyses revealed that N starvation results in genome‐wide TE activation without inducing obvious alteration of DNA methylation. Genetic analysis indicated that N starvation‐induced TE activation is also independent of other well‐established epigenetic mechanisms, including histone methylation and heterochromatin decondensation. Our results provide new insights into the regulation of TE activity under stressful environments in planta.
Answering the ethical call of the other: A test of the Strong Relationality Model of Relationship Flourishing
Authors: Wood Nathan D. , Fife Stephen T. , Parnell Kenneth J. , Ross D. Bruce 
Published: September 2022

AbstractThe philosophical framework of strong relationality has gained greater attention in scholarship and yet empirically testing models built on this important framework are rare. The present study tests predictions made by the Strong Relationality Model of Relationship Flourishing (SRM), which centers on the role of Ethical Responsiveness for relationship health. In doing so, we introduce common fate modeling as a methodological approach for strong relationality research. We used longitudinal data from 1512 couples collected as part of the German longitudinal panel study of families. Results support the Strong Relationality Model's prediction that Ethical Responsiveness (as measured by perceived partner support) positively alters the impact of stress on Gratitude‐Recognition (elements of the Responsible Action domain of the SRM), which then increases couples' intimacy (an element of the Relational‐Connectivity domain of the SRM). Recommendations for clinical assessment and intervention are given as well as recommendations for future research on the Strong Relationality Model.
The role of Vesalius and his contemporaries in the transfiguration of human anatomical science
Authors: Xiang Jinpo , Venkatesan Santhana 
Published: September 2022

AbstractThe understanding of human anatomy has been an endeavour spanning thousands of years from the Egyptians and Greeks in antiquity to the present day. Scholars and scientists have overcome great barriers to discover the inner workings and complexities of the human body, from personal challenges and prejudices to obstacles placed by society. Our present understanding of anatomy has accumulated over centuries, and progressive generations of physicians have contributed to the ever‐growing evidence‐based knowledge. This article explores the contributions made by Vesalius and his contemporaries in the first half of the sixteenth century. These enlightened scholars advanced anatomical knowledge and, perhaps more importantly, the scientific method, directly impacting the mindset and methodologies of future anatomists. Individuals such as Berengario da Carpi and Gabriele Falloppio produced bodies of work during their lifetime that were not only important in disputing the teachings of Galen of Pergamon, which had been accepted as almost unquestionable truths for a thousand years, but also instrumental in developing a new generation of scientists. The anatomists of the late renaissance were unable to resolve many of the factual inaccuracies of Galenic teaching but provided the groundwork for scientific thinking which future generations of anatomists benefited greatly from. The principles of documenting what is observed and establishing a methodical approach to question discrepancies in experiments would go on to influence physicians such as Harvey and Malpighi to investigate and draw correct conclusions in their research and ultimately advance our understanding of human anatomy to what it is today.
Applications of bakuchiol in dermatology: Systematic review of the literature
Authors: Puyana Carolina , Chandan Neha , Tsoukas Maria 
Published: September 2022

AbstractBackgroundBakuchiol (BAK), a meroterpene phenol abundant in the plant Psoralea corylifolia, is an emerging cosmeceutical agent with promising anti‐aging, anti‐inflammatory, and antibacterial properties. The trend for “clean” skincare products and search for anti‐aging retinoid alternatives have poised BAK as a “must‐have” ingredient in skincare.AimsOur aim was to review the data for the applications of BAK in dermatology.MethodsThis is a systematic review of PubMed.ResultsThirty articles matched our search terms [“Bakuchiol” and “Dermatology”] or [“Bakuchiol” and “Skin”] of which one did not meet inclusion criteria, 16 were pre‐clinical studies, seven clinical studies, three commentaries, two narrative reviews, and one report on adverse events. BAK has been mostly studied for its effects on photoaging, acne, and post‐inflammatory hyperpigmentation (PIH), showing beneficial results comparable to those achieved by topical retinoids. While having no structural resemblance to retinoids, BAK can function as a retinol analog, through retinol‐like regulation of gene expression. In in vivo studies, BAK was used alone or in combination with other products resulting in a significant reduction in photodamage, hyperpigmentation, wrinkle scores, and acne severity. Additionally, in vitro studies hinted at its anti‐cancer properties by inhibiting epidermal growth factor induced neoplastic cell transformation. Also, demonstrated potential applications in psoriasis by normalizing keratinocyte activity and in pigmentary disorders through inhibition of melanogenesis. There was one adverse event case reported of contact dermatitis in the literature.ConclusionsBakuchiol is a retinol alternative with anti‐aging, antibacterial, and anti‐inflammatory properties. Additional studies are warranted to better understand its applications in dermatology.
The experience of mood disorder and substance use: An integrative review
Authors: Crowe Marie , Inder Maree , Thwaites Bridgette 
Published: September 2022

Accessible SummaryWhat is known on the subject?

People with mood disorders often use substances.

There are several clinician‐driven hypotheses explaining the relationship.

What the paper adds to existing knowledge?

The paper draws together the existing research on the perceptions of those with lived experience of mood disorders on the reasons for using substances.

The participants in the studies identified using substances to manage their mood when treatment to manage their mood was not effective or acceptable, and as an escape from trauma and hardship.

What are the implications for practice?

Mental health nurses need an understanding of why people with mood disorders may use substances and the impact of this on their treatment.

Mental health nurses need to provide trauma‐informed care that emphasizes harm reduction for those who have mood disorders and substance use.

AbstractIntroductionSubstance use is highly prevalent among people with mood disorders. Effective treatment for these people requires a better understanding of the relationship between both mood and substance use from the perspectives of those with lived experience.QuestionWhat are the reasons those with lived experience of mood disorders give for substance use?MethodAn integrative review was conducted. The Joanna Briggs Institute suite of critical appraisal tools was used to evaluate the quality of individual studies. Data relevant to the review question were extracted, and the results were synthesized into themes.ResultsEighteen papers met the eligibility criteria. Three themes were identified across the included studies: Managing my mood, More Effective than prescribed medication, and Escape from trauma and hardship.DiscussionThis integrative review identified that people with a mood disorder who use substances described choosing to take substances to manage their mood, as an alternative to prescribed medications, and to cope with trauma and social hardships.Implications for PracticeMental health nurses need to provide care that recognizes why people use substances. They need to understand these reasons to provide a harm reduction and trauma‐informed model of care. Evidence‐based non‐pharmacological interventions for mood disorders need to be available as an alternative to medications or as a supplement.
Oxidative stress and cognition in ecology
Authors: Cram D. L. 
Published: September 2022

AbstractOxidative stress occurs when the body's antioxidant system is unable to prevent reactive oxygen species from causing cellular damage, and over the last two decades, oxidative stress has received extensive attention from behavioural ecologists investigating its links with life‐history traits including reproduction, growth, and immunity. Despite the breadth of studies examining oxidative stress in relation to animal behaviour, life‐history, and health, the role of oxidative stress in shaping variation in the cognitive abilities of wild animals has been almost entirely neglected. Here, I discuss how oxidative damage in the brain may affect cognitive performance in the wild, both directly and by mediating links to other life‐history traits. First, I outline evidence that the brain is particularly susceptible to oxidative stress and highlight medical studies demonstrating that oxidative damage impairs cognitive ability in humans and other animals. I then explore how oxidative stress may similarly affect cognition and behaviour in an ecological context, and the far‐reaching consequences this could have on wild animals' lives, including their fitness. Finally, I suggest methodological tools that could clarify the role of oxidative stress in cognitive ecology and approaches that combine existing ecological assays of behaviour and cognitive performance with bio‐medical experimental designs. While challenging to investigate, oxidative stress in the brains of wild animals may have profound consequences for their cognition and health, which currently remain almost entirely unexplored.
Identifying thresholds of nitrogen enrichment for substantial shifts in arbuscular mycorrhizal fungal community metrics in a temperate grassland of northern China
Authors: Wu Hui , Yang Junjie , Fu Wei , Rillig Matthias C. , Cao Zhenjiao , Zhao Aihua , Hao Zhipeng , Zhang Xin , Chen Baodong , Han Xingguo 
Published: September 2022

Summary

Nitrogen (N) enrichment poses threats to biodiversity and ecosystem stability, while arbuscular mycorrhizal (AM) fungi play important roles in ecosystem stability and functioning. However, the ecological impacts, especially thresholds of N enrichment potentially causing AM fungal community shifts have not been adequately characterized.

Based on a long‐term field experiment with nine N addition levels ranging from 0 to 50 g N m−2 yr−1 in a temperate grassland, we characterized the community response patterns of AM fungi to N enrichment.

Arbuscular mycorrhizal fungal biomass continuously decreased with increasing N addition levels. However, AM fungal diversity did not significantly change below 20 g N m−2 yr−1, but dramatically decreased at higher N levels, which drove the AM fungal community to a potentially unstable state. Structural equation modeling showed that the decline in AM fungal biomass could be well explained by soil acidification, whereas key driving factors for AM fungal diversity shifted from soil nitrogen : phosphorus (N : P) ratio to soil pH with increasing N levels.

Different aspects of AM fungal communities (biomass, diversity and community composition) respond differently to increasing N addition levels. Thresholds for substantial community shifts in response to N enrichment in this grassland ecosystem are identified.
Time for different stories: Reflections on IPONS panel addressing current debates in nursing theory, education and practice
Authors: Hopkins‐Walsh Jane 
Published: September 2022

AbstractOn 4 February 2021 a group of nurse scholar‐educators, nurses and other interested folks came together for the second of two virtual events to think together about the role of philosophy in the nursing world. The live streamed open access event provided an opportunity in the COVID‐19 pandemic for over 400 people to listen to five nursing scholars' presentations and to interact virtually through comments in chat and on the @IPONSociety Twitter social media platform. By reading the comments and questions that were generated, and by looking at the social media comments related to the event, it is apparent that philosophy is an important thinking practice for nurses but many audience members critically expressed they felt excluded. Critical issues were raised by participants in chat and on Twitter—pointedly around the need for more representative voices—including the imperative to open nursing philosophy to diverse and disparate worldviews. This dialogue provides a summary of critical points raised during the live question and answer session for the panel entitled Addressing Current Debates in Nursing Theory, Education, Practice as well as examing comments selected from the @IPONSociety Twitter space in response to the panel. One commenter said it was great to see the discussion being lifted up from the influential roots of white supremacy, while other nurses expressed that they wished the panellists themselves were more diverse. In discussion of key takeaway, links are made to historical and ongoing structural oppressions in nursing where thinking practices like nursing philosophy and theory are still dominated by world views emanating from positionalities of able‐bodied cis‐gendered heterosexual western eurocentric whiteness.
Surgical Tool Handle Vibration‐Based Drilling State Recognition During Hip Fracture Fixation
Authors: Xia Guangming , Liu Wei , Bai He , Xue Yuan , Dai Yu , Lei Ping , Zhang Jianxun 
Published: September 2022

ObjectivesTraditional manual drilling during hip fracture fixation can easily lead to unstable fixation and vascular damage. This study aimed to investigate a safe and easy‐to‐use robot‐assisted method to automatically drill bone and distinguish critical bone drilling states with high accuracy in real‐time for the bone hole‐making process during hip fracture fixation.MethodsA bone‐drilling robotic system was designed to automatically create holes in the femoral neck. Four fresh pig femurs were drilled at the posterosuperior femoral neck using three modes: “all‐in” (AI), “in‐out‐in” (IOI), and “percutaneous fixation” (PF). A high‐frequency accelerometer captured the generated vibrations of the drill handle, which were then transferred to a personal computer using a data acquisition card. Five bone drilling states are defined, including: “drill idling,” “initial drilling,” “in the cancellous bone,” “out the femoral neck,” and “in the cortical bone.” The harmonic distribution of the vibration signal was extracted by fast Fourier transform (FFT) and used as a critical feature to identify different drilling states. To prove the difference in the harmonic distribution at different drilling states, an independent sample t‐test was used to compare the percentage of the first harmonic amplitude in the first 10 harmonics at each drilling state. A neural network classifier was trained with the frequency spectrum as the input and the drilled state as the output to distinguish the critical bone drilling states with high accuracy in real‐time. The classifier was trained and tested on four specimens to ensure that the surgical robot could accurately identify the five drilling states.ResultsIn each specimen, the harmonic distributions of the drilling vibration at different drilling modes were significantly different (p < 0.05). The average recognition accuracies of the drilling state for the four specimens were all higher than 84%. The three defined modes were distinguished with extremely high accuracies. The recognition accuracies of “in the cancellous bone” for specimens 1 to 4 were 83.2%, 84.8%, 92.9%, and 84.7%. The recognition accuracies of “in out the femoral neck” from specimens 1 to 4 are 98.2%, 88.4%, 95.8%, and 88.8%. The recognition accuracies of “in the cortical bone” for specimens 1 to 4 were 94.6%, 80.8%, 95.5%, and 85.8%.ConclusionsThe proposed robot‐assisted method can automatically distinguish five critical bone‐drilling states with high accuracy in real‐time to avoid weak fixation and damage to the lateral epiphyseal artery.
Consumer research priorities for pediatric anesthesia and perioperative medicine
Authors: Sommerfield Aine , Sommerfield David , Bell Emily , Humphreys Susan , Taverner Fiona , Lee Kenneth , Frank Belinda , von Ungern‐Sternberg Britta Sylvia 
Published: September 2022

AbstractBackgroundConsumer‐driven research is increasingly being prioritized.AimOur aim was to partner with consumers to identify the top 10 research priorities for pediatric anesthesia and perioperative medicine. The ACORN (Anesthesia Consumer Research Network) was formed to collaborate with children and families across Australia.MethodsA prospective online survey was developed to generate research ideas from consumers. The survey was developed in Qualtrics, a survey research platform. Consumers were invited to participate through poster advertising, social media posts, via consumer networks at participating hospitals and in addition 35 national consumer/patient representative organizations were approached. We also conducted a similar idea generating survey for clinicians through email invitation and via Twitter. A second round of surveys was conducted to prioritize the long list of research questions and a shortlist of priorities developed. A single consensus meeting was held, and a final consensus list of top 10 priorities emerged.ResultsA total of 281 research ideas were submitted between 356 consumers in the idea generating survey and from four consumer/patient representative groups. Seventy‐five clinicians responded to the clinician idea generation survey. This was consolidated into 20 research ideas/themes for the second survey for each group. 566 responses were received to the consumer prioritization top 10 survey and 525 responses to the clinician survey. The consensus meeting produced the final 10 consumer research priorities.ConclusionThis study has given Australian consumers the opportunity to shape the anesthesia and perioperative medicine research agenda for pediatric patients both nationally and internationally.