bluuebunny/crossref_metadata_2025_split huggingface dataset:
Quality of life in patients with primary hyperparathyroidism after surgery
Authors: Nikitina T. P. , Gladkova I. N. , Rusakov V. F. , Chernikov R. A. , Karelina Yu. V. , Efremov S. M. , Ionova T. I. 
Published: March 2022

BACKGROUND: For a comprehensive assessment of the effect of surgery in patients with primary hyperparathyroidism (PHPT), as well as for monitoring the condition of patients after treatment, it sounds reasonable to evaluate quality of life (QoL) and symptoms in PHPT patients before and after surgery.AIM: The aim of this study was to assess changes in the QoL and symptoms in patients with PHPT after surgery.MATERIALS AND METHODS: During prospective observational study, patients filled out QoL questionnaires and evaluated the presence and severity of their symptoms prior to parathyroidectomy (PTE) and 3, 12 months after surgery. Statistical analysis included the following methods: Student’s t-test or Wilcoxon’s non-parametric test, the generalized estimating equations (GEE), correlation analysis, χ2 and McNemar tests.RESULTS: The study included 72 patients (mean age 52 years, 97.2% female) with symptomatic (68.1%) and asymptomatic (31.9%) PHPT. Before surgery patients with PHPT exhibited significantly decreased role functioning, physical and social well-being, and vitality. Half of PHPT patients experienced moderate-to-severe symptoms such as weakness, fatigue, loss of concentration, mood changes, as well as joint and bone pain; the association between symptoms experienced and the extent of QoL impairment before surgery was shown. Three months after PTE improvement in both physical and psychological components of QoL was shown. Positive QoL changes were demonstrated in patients with both symptomatic and asymptomatic PHPT and they preserved for 12 months after surgery. Also within 12 months after PTE significant decrease in PHPT-associated symptoms such as weakness, fatigue, loss of concentration and mood changes was found.CONCLUSION: The results obtained demonstrate efficacy of PTE from the patient’s perspective and confirm the value of QoL assessment in PHPT patients in management of this patients’ population both for decision making and for evaluation of benefits of surgery and the degree of recovery of patients at long term follow-up.
Features of the use of synthetic analogues of thyroid hormones: а 2020 THESIS* questionnaire survey of members of the Belarusian Public Medical Association of Endocrinology and Metabolism
Authors: Shepelkevich A. P. , Dydyshka Yu. V. , Yurenya E. V. , Lоbashova V. L. , Attanasio R. , Hegedüs L. , Nagy E , Negro R , Papini E. , Perros P. 
Published: March 2022

BACKGROUND. The standard treatment for hypothyroidism is levothyroxine (LT4), which in the Republic of Belarus is available in tablet form whereas liothyronine (LT3) is not registered, but patients can purchase them on their own abroad.AIM. This study aimed to investigate Belarusian endocrinologists’ attitude of thyroid hormones in hypothyroid and euthyroid patients.MATERIALS AND METHODS. An online survey was conducted, for which members of the Belarusian Medical Association of Endocrinology and Metabolism were invited by posting information in the group chat and by e-mail. The research period was from October 1 to December 26, 2020. 210 questionnaires were received, 146 of which were used.RESULTS. The majority of participants, 145 (99.3%), indicated that they were using LT4 as the first-choice drug for the treatment hypothyroidism. Sixty-one (41.8%) doctors answered that LT3 + LT4 combination likely can be used in patients with long-term untreated hypothyroidism and 15 (10.3%) — in patients with persistent symptoms of hypothyroidism, despite biochemical euthyroidism on therapy LT4. Over half of the respondents 84 (57.5%) answered that thyroid hormone therapy was never indicated for euthyroid patients, but 50 (34.2%) would consider it for female infertility with high level of thyroid antibodies and 36 (24.7%) for simple goiter growing over time. In various conditions that could interfere with absorption of LT4, most responding Belarusian endocrinologists do not expect a significant difference with different formulations (tablets+“I do not expect major changes in different forms” vs. “soft gel capsules”+“liquid solution”; p <0.001). Persistent symptoms of hypothyroidism on the background of LT4 replacement therapy with the achievement of the target TSH can mainly be caused by psychosocial factors, concomitant diseases, unrealistic patient expectations, chronic fatigue syndrome, and the burden of chronic disease.CONCLUSION. The method of choice of Belarusian endocrinologists in the treatment of hypothyroidism is LT4 replacement therapy, but the appointment of LT4 + LT3 combination therapy can be considered in certain clinical situations. As a rule, endocrinologists do not prescribe LT4 in patients with euthyroidism and do not expect a significant difference when using other forms of levothyroxine.
Melatonin status in obese patients with ovarian dysfunction at reproductive age
Authors: Andreeva E. N. , Grigoryan O. R. , Absatarova Yu. S. , Sheremetyeva E. V. , Mikheev R. K. 
Published: March 2022

BACKGROUND: Melatonin is the main hormone of the pineal gland. By regulating circadian rhythms and being an immune regulator and antioxidant, this hormone takes part in the work of the ovaries: its high concentrations block apoptosis and neutralize reactive oxygen species involved in folliculogenesis, ovulation, egg maturation and corpus luteum formation.AIM: To study melatonin status and its relationship with menstrual dysfunction and sleep disorders in obese women of reproductive age.MATERIALS AND METHODS. In a one-stage comparative study, women 18-35 years old took part: 30 patients with obesity and menstrual disorders of an inorganic nature and 30 healthy women in the comparison group with normal weight and regular menstrual cycle. All participants underwent a questionnaire to identify somnological disorders, and the level of melatonin in saliva and 6-sulfatoxymelatonin in urine was also investigated.RESULTS: In the group of patients with obesity (n=30), various sleep disorders were encountered in 47% of cases (p=0.003), including more often obstructive sleep apnea syndrome was recorded (30% of cases), and a correlation was found between the indicators of the questionnaire survey of subjective sleep characteristics and body mass index of patients (r=0.450, p=0.030) compared with a group of healthy women with normal weight (n=30). In the main group, the level of melatonin in saliva was statistically significantly lower than in the control: median 12.6 pg / ml and 25.5 pg / ml, respectively (p=0.008), the same pattern was recorded for 6-sulfatoxymelatonin: 14, 72 pg / ml and 31.12 pg / ml, respectively.CONCLUSION: Patients with obesity and menstrual dysfunction are more likely to suffer from various sleep disorders and have lower levels of melatonin in saliva and 6-sulfatoxymelatonin in urine.
Visual Literacy, Cognitive Learning Approach and Instructional Technology
Authors: GÜNEY Zafer 
Published: March 2022

The development of technology
has affected the contribution of perception management on learning in instructional
technology with its acceleration as well as leading the interaction between
people in social life. The development of technology makes it important to
integrate the perceptual design language into the culture of the society.

The concepts of "Visual Intelligence" and
"Visual Memory" have a positive relationship with the concept of "visual literacy“. Visual learning,
visual thinking and visual communication, which form visual literacy, should be
remembered in the learning process and should not be forgotten as a whole
(Dwyer, 1994; İpek, 2003). Visual learning is to provide learning through
visuals in the learning process, visual thinking is the interaction of vision,
imagination, illustration-drawing (McKim, 1980), and visual communication is the
ability to maintain a continuous connection between these sources of
information. The use of visuals in education and training is a factor that
increases the effectiveness, efficiency and attractiveness of the
learning-teaching process and positively affects motivation. The role of a
material prepared in accordance with the instructional design models in the
teaching-learning process must be effective to support the visual perception
that can lead the instructional purpose. The teacher, who will realize the
learning process and direct the perception of the student, should be able to
master the characteristics of the student population while designing the
learning process and materials. and plan with new technologies.
The role of the C domain in the thermostability of GH70 enzymes investigated by domain swapping
Authors: Molina Manon , Prévitali Thomas , Moulis Claire , Cioci Gianluca , Remaud-Siméon Magali 
Published: March 2022

Abstract
Sucrose-active enzymes belonging to the glycoside hydrolase (GH) family 70 are attractive tools for the synthesis of oligosaccharides, polysaccharides or glycoconjugates. However, their thermostability is an important issue for the development of robust and cost-effective enzyme-based processes. Indeed, GH70 enzymes are mesophilic and no thermophilic representatives have been described so far. Furthermore, structurally guided engineering is a challenge given the size of these proteins (120 to 250 kDa) and their organization in five domains. Herein, we have investigated the possible role of the domain C in the stability of GH70 enzymes. The alternansucrase (ASR) is the most stable enzyme of the GH70 family. Structural comparison of ASR to other GH70 enzymes highlighted the compactness of its domain C. We assumed that this atypical structure might be involved in the stability of this enzyme and decided to introduce this domain in another much less stable GH70 enzyme of known three-dimensional structure, the branching sucrase GBD-CD2. The chimeric GBD-CD2 exhibited a lower specific activity on sucrose substrate but its specificity was unchanged with the enzyme remaining specific for the branching of dextran via α-1,2 linkage formation. Interestingly, the chimera showed a higher melting temperature and residual activity than the wild-type enzyme after 10 min incubation at 30 °C showing that the domain C can affect GH70 enzyme stability and could be a potential target of both random or rational mutagenesis to further improve their stability.
Large solutions of a class of degenerate equations associated with infinity Laplacian
Authors: Li Cuicui , Liu Fang 
Published: March 2022

Abstract
In this article, we investigate the boundary blow-up problem

Δ

∞

h

u
=
f

(

x
,
u

)

,

in

Ω
,

u
=
∞
,

on

∂
Ω
,

\left\{\begin{array}{ll}{\Delta }_{\infty }^{h}u=f\left(x,u),& {\rm{in}}\hspace{0.33em}\Omega ,\\ u=\infty ,& {\rm{on}}\hspace{0.33em}\partial \Omega ,\end{array}\right.

where

Δ

∞

h

u
=
∣
D
u

∣

h
−
3

⟨

D

2

u
D
u
,
D
u

⟩

{\Delta }_{\infty }^{h}u=| Du\hspace{-0.25em}{| }^{h-3}\langle {D}^{2}uDu,Du\rangle

is the highly degenerate operator related to infinity Laplacian which comes from the absolutely minimizing Lipschitz extension and has a close relationship with the random game named tug-of-war. When the function

f

f

satisfies the Keller-Osserman-type condition, we establish the existence of the boundary blow-up viscosity solution. Moreover, for the separable case

f

(

x
,
u

)

=
b

(

x

)

g

(

u

)

f\left(x,u)=b\left(x)g\left(u)

, we establish the asymptotic estimate of the blow-up solution near the boundary under some regular conditions of the domain. Based on the asymptotic estimate and comparison principle, we obtain the uniqueness of the large viscosity solution. During this procedure, we also study the non-existence of the large solution. For the separable case, we show that the Keller-Osserman-type condition is sufficient and necessary for the existence of the boundary blow-up viscosity solution.
Identification of contagious SARS-CoV-2 infected individuals by Roche’s Rapid Antigen Test
Authors: Kessler Harald H. , Prüller Florian , Hardt Melina , Stelzl Evelyn , Föderl-Höbenreich Esther , Pailer Sabine , Lueger Andreas , Kreuzer Philipp , Zatloukal Kurt , Herrmann Markus 
Published: March 2022

Abstract

Objectives
Rapid antigen tests (RAT) can provide valuable information on the presence or absence SARS-CoV-2 within 15 min without the need of a laboratory. The analytical and diagnostic characteristics of available RATs has led to the question whether they can safely distinguish between infectious and non-infectious patients in an acute care setting.

Methods
Three nasopharyngeal swabs for the analysis by RAT, reverse transcriptase real time polymerase chain reaction (RT-qPCR), and a cell culture based infection assay were collected from 67 patients that presented to the emergency department of the University Hospital of Graz (Austria). The first swab was used for on-site RAT testing in the emergency department using the Roche SARS-CoV-2 RAT. The second swab was sent to the central laboratory of the hospital for RT-qPCR with two independent methods (Cepheid Xpert® Xpress SARS-CoV-2 assay and Roche Cobas SARS-CoV-2 Test) and repeat RAT testing using the same commercial test. With the third swab a cell culture-based infection assay was performed.

Results
The RATs performed from independent samples showed substantial agreement (Cohen’s-kappa: 0.73, p<0.001). All patients with a positive RAT had positive RT-qPCR with cycle threshold (ct) values <25. Fifteen out of 55 RAT-negative samples were RT-qPCR positive with ct values between 25 and 40. The inoculation of cell cultures with RT-qPCR negative swabs and RT-qPCR positive swabs with ct values >25 did not induce cytopathic effects that were related to SARS-CoV-2. The infection assays from four RAT-negative patients showed cytopathic effects that were induced by other pathogens.

Conclusions
The SARS-CoV-2 RAT from Roche Diagnostics is a valuable tool for managing symptomatic patients. RAT-negative patients may be regarded as non-contagious.
Hardness of surface-densified wood. Part 1: material or product property?
Authors: Scharf Alexander , Neyses Benedikt , Sandberg Dick 
Published: March 2022

Abstract
The established methods for testing the hardness of wood are of questionable value for assessing the performance of surface-densified wood, since the density profile beneath the densified surface is an important property that needs to be considered. The purpose of this study was to evaluate the influence of the density profile of surface-densified wood and the hardness test parameters, such as indenter geometry and applied load on the measured hardness. The influence of the density profile varied considerably depending on the hardness test parameters. This can make a comparison of hardness values of surface-densified wood prone to misinterpretation. The selection of hardness test parameters should either be product-specific, or the density profile itself should be used to evaluate the hardness of surface-densified wood. A strong influence of the density profile on the indentation depth development during the hardness tests indicates the possibility of predicting the density profile based on the hardness test methods.
Microstructural, functional groups and textural analysis of expanded polyethylene reinforced polystyrene composites with recycled aluminium as ternary component
Authors: Abdulkareem Sulyman A. , Abdulkareem Maryam T. , Ighalo Joshua O. , Adeniyi Adewale G. , Amosa Mutiu K. 
Published: March 2022

Abstract
The aim of this study is to utilise recycled aluminium, expanded polyethylene (EPE) and expanded polystyrene (EPS) to develop a ternary composite. The study was a preliminary investigation into the microstructural, functional groups and textural properties of the novel material. The material was characterised by Fourier Transform Infra-Red Spectroscopy (FTIR), Scanning Electron Microscopy with Energy Dispersive X-ray analysis (SEM-EDX) and Branueur-Emmet-Teller analysis (BET). The shifts in the FTIR peaks for each of the polymer feedstock in comparison with the binary composite indicated chemical interactions between them. For the ternary composites, there were shifting of peaks as the proportion of the aluminium increased in the composites, suggesting the influence of aluminium on the curing process. Beyond 20% Al filler, there were no significant functional group changes in the composite. SEM revealed that an increase in aluminium filler percentage led to better interfacial adhesion and dispersion. BET revealed that the blend of polystyrene and powdered EPE reduces the surface area, while the introduction of the aluminium particles within the range observed increases the surface area of the hybrid composites formed. As the dispersion of aluminium increased, pore volume increased while pore size decreased.
Ground state solutions of nonlinear Schrödinger equations involving the fractional p-Laplacian and potential wells
Authors: Chen Yongpeng , Niu Miaomiao 
Published: March 2022

Abstract
The purpose of this paper is to investigate the ground state solutions for the following nonlinear Schrödinger equations involving the fractional p-Laplacian

(

−
Δ

)

p

s

u

(

x

)

+
λ
V

(

x

)

u

(

x

)

p
−
1

=
u

(

x

)

q
−
1

,

u

(

x

)

≥
0
,

x
∈

R

N

,

{\left(-\Delta )}_{p}^{s}u\left(x)+\lambda V\left(x)u{\left(x)}^{p-1}=u{\left(x)}^{q-1},\hspace{1em}u\left(x)\ge 0,\hspace{0.33em}x\in {{\mathbb{R}}}^{N},

where

λ
>
0

\lambda \gt 0

is a parameter,

1
<
p
<
q
<

N
p

N
−
s
p

1\lt p\lt q\lt \frac{Np}{N-sp}

,

N
≥
2

N\ge 2

, and

V

(

x

)

V\left(x)

is a real continuous function on

R

N

{{\mathbb{R}}}^{N}

. For

λ

\lambda

large enough, the existence of ground state solutions are obtained, and they localize near the potential well int

(

V

−
1

(

0

)

)

\left({V}^{-1}\left(0))

.
Crystal structure of 3-(difluoromethyl)-1-methyl-N-(4,11,11-trimethyl-1,2,3,4-tetrahydro-1,4-methanoacridin-9-yl)-1H-pyrazole-4-carboxamide monohydrate, C23H26F2N4O3
Authors: Zhong Liang , Wang Jiu-Long , Zhu Shuang-Shi , Chen Shang-Xing , Peng Da-Yong 
Published: March 2022

Abstract
C23H26F2N4O3, orthorhombic, P212121 (no. 19), a = 11.6524(10) Å, b = 11.9777(10) Å, c = 15.9058(13) Å, V = 2220.0(3) Å3, Z = 4, R

gt
(F) = 0.0305, wR

ref
(F
2) = 0.0751, T = 296(2) K.
Antibacterial nanomaterials: Upcoming hope to overcome antibiotic resistance crisis
Authors: Hochvaldová Lucie , Večeřová Renata , Kolář Milan , Prucek Robert , Kvítek Libor , Lapčík Lubomír , Panáček Aleš 
Published: March 2022

Abstract
When combined with nanomaterials, antibiotics show antibacterial activity against susceptible and resistant bacterial strains at significantly lower concentrations. Unfortunately, to date, no research study has examined the effect of the antibiotic mode of action and mechanism of bacterial resistance on the effectiveness of combined antibacterial treatment with nanomaterials. Therefore, in this review, we performed a thorough analysis and critical evaluation of previously published data related to the combined antibacterial effect of antibiotics with nanostructured materials with a targeted focus on relationships between antibiotic’s modes of action and bacterial resistance mechanisms for relevant nanomaterials and their impact on the resulting synergistic effects. Following thorough data analysis and critical discussion, we have discovered and are the first who present that antibiotic’s mode of action and bacterial resistance mechanism determine the final effectiveness of combined antibacterial treatment with nanomaterials. We therefore conclude that only certain combinations of nanomaterials with antibiotics can lead to the enhancement and restoration of the antibacterial effectiveness of antibiotics against certain resistant bacteria. Moreover, the recently occurring development of bacterial resistance towards nanomaterials is also discussed together with a possibility of how to prevent it. All discovered findings provide a new view and perspective on this issue helping to navigate further approaches to combat the antibiotic crisis.
Präparation einer TEM-Probe aus einem metallographischen Schliff
Authors: Mühle Uwe , Jansen Sören , Leinert Susann , Breuer Dirk 
Published: March 2022

Kurzfassung
Die Möglichkeiten transmissionselektronenmikroskopischer Analysen an komplexen Werkstoffsystemen sind in hohem Maße von den verfügbaren Präparationsmethoden abhängig. Die Focused-Ion-Beam-Technik mit der Möglichkeit hochqualitativer Zielpräparationen mit Genauigkeiten im Bereich 10 -8 m erweitert das Anwendungsspektrum beträchtlich. Die vorgestellte Methode nutzt einen metallographischen Schliff, an dem mit lichtoptischen oder rasterelektronenmikroskopischen Mitteln eine Charakterisierung und Auswahl der speziell interessierenden Details stattfinden kann. Untersuchungsobjekt ist das Grenzflächensystem einer Lötverbindung, wie sie bei der Montage von Chips entsteht. Der metallographische Schliff wird für die Arbeit im Focused-Ion-Beam-Gerät vorbereitet, mit einem Liftout-System wird eine Lamelle entnommen und an einem TEM-Probenträger befestigt. Die finalen Polierschritte erzeugen eine TEM-Probe, die für eine Reihe von zusätzlichen Untersuchungen (analytische TEM, Beugungsuntersuchungen) besonders geeignet ist.
Ermittlung von Zerspankraftkoeffizienten für FKV
Authors: Merx Marcel , Löser Michael , Müller Jens , Großmann Knut 
Published: March 2022

Abstract
Die spanende Bearbeitung von Bauteilen aus Faserkunststoffverbundwerkstoffen (FKV) ist mit Werkzeugmaschinen häufig unwirtschaftlich, da meist großer Bewegungsraum bei moderaten Genauigkeitsanforderungen und Prozesskräften erforderlich ist. Einen Lösungsansatz bietet die robotergestützte Bearbeitung. Zur simulationsgestützten Auslegung eines Roboter-Bearbeitungssystems wird ein Prozesskraftmodell benötigt. Eine Methodik zur Modellierung der Zerspankräfte und die Bestimmung der erforderlichen Zerspankraftkoeffizienten auf Basis experimenteller Untersuchungen werden in diesem Beitrag vorgestellt.
Green Controlling – Ressourcenorientierte Steuerung von Unternehmen
Authors: Rackow Tobias , Schuderer Peter , Franke Jörg 
Published: March 2022

Abstract
Der erste Schritt zur Hebung von Energieeinsparpotenzialen ist das Aufdecken unnötiger Verbräuche. Folglich ist es notwendig, den Unternehmen ein Werkzeug an die Hand zu geben, mittels dessen die Energieströme im Produktionsprozess transparent gemacht und visualisiert werden können. Hierzu bietet die Green Controlling-Methodik einen ganzheitlichen Lösungsansatz, indem sie Energie als vierte Hauptzielgröße – neben Zeit, Kosten und Qualität – in die Unternehmensführung aufnimmt und so dem gewichtigen Stellenwert dieser Größe gerecht wird.
Material- und Energieeffizienz in der Produktion
Authors: Wulf Serjosha , Ansari Sarah Majid , Nyhuis Peter 
Published: March 2022

Abstract
Ressourceneffizienz ist als Begriff eng mit dem Thema der Nachhaltigkeit verbunden. Ziel nachhaltiger Unternehmen ist es, Gewinne ökologisch und sozial verantwortungsvoll zu erwirtschaften, um so langfristig am Markt bestehen zu können. Voraussetzung hierzu ist ein grundlegendes Umdenken auf Managementebene. Die Unternehmensleitung muss sich zu einem schonenden Umgang mit den eingesetzten Produktionsressourcen bekennen und einen effizienten Umgang fördern. Dieser Beitrag zeigt einen Ansatz zur konkreten Einführung der Thematik in einen laufenden Produktionsbetrieb auf und schildert erste Erfahrungen aus der Praxis.*