bluuebunny/crossref_metadata_2025_split huggingface dataset:
EHR-Safe: Generating High-Fidelity and Privacy-Preserving Synthetic Electronic Health Records
Authors: Yoon Jinsung , Mizrahi Michel , Ghalaty Nahid , Jarvinen Thomas , Ravi Ashwin , Brune Peter , Kong Fanyu , Anderson Dave , Lee George , Meir Arie , Bandukwala Farhana , Kanal Elli , Arik Sercan , Pfister Tomas 
Published: December 2022

Abstract
Privacy concerns often arise as the key bottleneck for the sharing of data between consumers and data holders, particularly for sensitive data such as Electronic Health Records (EHR). This impedes the application of data analytics and ML-based innovations with tremendous potential. One promising approach to avoid such privacy concerns is to instead use synthetic data. We propose a novel generative modeling framework, EHR-Safe, for generating highly realistic and privacy-preserving synthetic EHR data. EHR-Safe is based on a two-stage model that consists of sequential encoder-decoder networks and generative adversarial networks. Our innovations focus on the key challenging aspects of real-world EHR data: the data are heterogeneous, consisting of numerical and categorical features with distinct characteristics; they contain time-varying features with highly-varying sequence lengths; and the features are often highly sparse. Under numerous evaluations, we demonstrate that the fidelity of EHR-Safe is very high, i.e. it has almost-identical properties with real data while yielding almost-ideal performance in practical privacy metrics.
NUP98::NSD1 and FLT3-ITD collaborate to generate acute myeloid leukemia
Authors: Aplan Peter , Matsukawa Toshihiro , yin  , Nigam Nupur , Negi Vijay , Li Li , Small Donald , Zhu Yuelin , Walker Robert , Meltzer Paul 
Published: December 2022

Abstract
Nucleoporin 98 (NUP98) fusion genes and FMS-related tyrosine kinase 3 gene (FLT3) internal tandem duplications (ITDs) are recurrent events in patients with acute myeloid leukemia (AML). The NUP98::NSD1 fusion, which joins the amino terminal portion of NUP98 to the carboxy terminal portion of NSD1 (Nuclear receptor-binding SET Domain 1) is the most common NUP98 fusion in human AML. AML patients with NUP98::NSD1 fusion typically also have a FLT3-ITD mutation, and the combination of these two oncoproteins results in a poor prognosis. We established NUP98::NSD1 transgenic mice as an in vivo model. Although the penetrance of AML in mice that expressed a NUP98::NSD1 fusion was low, the incidence of AML increased dramatically when accompanied by a FLT3-ITD mutation. Gene expression profiling showed that murine NUP98::NSD1/FLT3-ITD AML were myelomonocytic, with an expression profile similar to human NUP98::NSD1 AML. Also similar to human AML, the wild type Flt3 allele was frequently lost in murine NUP98::NSD1/FLT3-ITD AML. Whole exome sequencing of NUP98::NSD1/FLT3-ITD AML revealed few Tier 1 somatic mutations, suggesting that the NUP98::NSD1 fusion protein and FLT3-ITD may be sufficient for leukemogenesis. This study demonstrates that the NUP98::NSD1 fusion gene is leukemogenic in vivo, and provides a model for pre-clinical studies.
Quality-of-life endpoints in women of childbearing age with hidradenitis suppurativa: a tertiary-care-centre-based study
Authors: Tsentemeidou Aikaterini , Sotiriou Elena , Bakirtzi Katerina , Papadimitriou Ilias , Chatzi-Sotiriou Themis , Panagopoulou Angeliki , Kougkas Nikolaos , Lallas Aimilios , Vakirlis Efstratios 
Published: December 2022

Abstract
Hidradenitis suppurativa (HS) principally affects women of childbearing age, who face gender-specific challenges, with lower life-quality than men. To investigate various quality-of-life endpoints in women of childbearing age with HS. A cross-sectional questionnaire-based study was performed at a university dermatology department. Eighteen yes/no and one open-ended questions explored impact of HS on social life, sexual life, family planning, working life and healthcare-backed support. Ninety-six women were included. Most women (80.8%) carry a stigma because of HS, which also affects their choice of clothes and social relationships. Sexual impairment affects 73.1% of women. One third of women wants less or no children because of HS, 67.7% worry about its impact on pregnancy, birth and the postpartum, and 84.6% worry about the impact of HS treatment on fertility and their babies’ health. Almost 43% fear losing their job because of HS, 34.4% are discriminated against at work and 33.3% state HS has hindered their career. Most women are not adequately informed about their disease or available support groups/material and 41.7% have not received good enough care through pregnancy/postpartum. Life-quality endpoints should be meticulously screened in women. Multidisciplinary-led treatment should be offered during pregnancy and the postpartum.
Applying radial basis function neural network for comprehending properties of each cluster of fuzzy c-means in coordinates analysis (case study in Iran)
Authors: Shahnavehsi Reza 
Published: December 2022

Abstract
For notifying the properties of special area with similar properties, clustering analysis is really helpful, and neural network methods have ability to create usable model. One of the best ways for clustering is fuzzy c-means, and fuzzy c-means by the basis of fuzzy method divides data set to different clusters. Radial basis function is neural network which is utilizing spread and this algorithm’s layers like input layer, hidden layer and output layer for creating effective neural network. This paper is introduced a novel method, in this method data points (longitude and latitude of main cities of Iran) by using fuzzy c-mean algorithm is divided to different clusters then for each cluster RBF neural networks is defined separately, and this method is FCM-RBF. The outcome of FCM-RBF build neural network for each cluster separately, and result of this study shows that radial basis function neural network can enhance the quality of analysis of outcomes of this kind of clustering and by applying this algorithms different clusters with same properties is calculated and create neural network separately for each cluster, and three clusters are proposed for this algorithms and data points of cluster2 and cluster3 has acceptable rate of adaptability with RBF neural network but data points of cluster1 can’t adapt themselves with neural network perfectly, and validity of outcomes of this clustering increase by using radial basis function neural network. In this algorithm data points of each clusters can separately analyze which is cause better comprehending of study area.
Do It Yourself: how can we use Almonds and Almond Shells in cosmetics? Easy body exfoliant and facial mask
Authors: Gonçalves Sara , Gaivão Isabel 
Published: December 2022

Abstract

Avoiding the potentially dangerous chemicals found in many of today's commercially made beauty products is a good reason for making our own cosmetic products. Almonds have been used for centuries in cosmetics. They enhance the glow and fairness of the skin. Almonds are easily obtained in the Trás-os-Montes area (Portugal), and suggestions on how to use them in cosmetics should be made. This study presents a method for using almonds and almond shells as a cosmetic product that can be reproduced domestically.
Biochronological ages for South African Plio-Pleistocene hominins
Authors: Thackeray Francis , Dykes Susan 
Published: December 2022

Abstract
The ages of South African Plio-Pleistocene hominin fossils (Australopithecus africanus, A. prometheus and early Homo) are in question. Cosmogenic dates for Australopithecus from Sterkfontein Member 4 published by Granger et al (2022) range between 3.4 and 3.7 Ma. By contrast, biochronological age estimates for this genus, as published by Frost et al (2022) from cercopithecid primates, range between 2 – 2.7 Ma. In this study a biochronological approach based on hominin teeth is adopted, initially using an equation whereby the ratio of mesiodistal (MD) and buccolingual (BL) diameters of East African hominin lower first molars (M1) can be related to radiometric dates for a sample of specimens attributed to A. afarensis, H. habilis, H. rudolfensis and H. erectus, ranging in age from 0.9 to 3.8 Ma. The equation is applied to MD/BL ratios for South African hominins. On the basis of that equation, the mean estimated age for 20 molars attributed to Australopithecus from Sterkfontein is 2.67 ± 0.53 Ma, ranging widely between 1.81 and 3.50 Ma. Results obtained by both Granger et al (2022) and by Frost et al (2022) fall closely within that range. The age estimate for the holotype of A. africanus from Taung is 2.57 Ma, while the dates for MLD 2 and MLD 40 (attributed to A. prometheus or A. africanus) from Makapansgat are 3.06 and 2.99 Ma respectively. Sterkfontein hominins controversially attributed to early Homo (Stw 151 and Sts 9) have ages of 1.80 and 2.01 Ma respectively.
Attosecond-Angstrom free-electron-laser towards the cold beam limit
Authors: Habib A. F. , Manahan G.G. , Scherkl P. , Heinemann T. , Sutherland A. , Altuiri R. , Alotaibi B. M. , Litos M. , Cary J. , Raubenheimer T. , Hemsing E. , Hogan M. , Rosenzweig J.B. , Williams P. H. , McNeil B. W. J. , Hidding B. 
Published: December 2022

Abstract
Electron beam quality is paramount for X-ray pulse production in free-electron-lasers (FELs). State-of-the-art linear accelerators (linacs) can deliver multi-GeV electron beams with sufficient quality for hard X-ray-FELs, albeit requiring km-scale setups, whereas plasma-based accelerators can produce multi-GeV electron beams on metre-scale distances, and begin to reach beam qualities sufficient for EUV FELs.
We show, that electron beams from plasma photocathodes many orders of magnitude brighter than state-of-the-art can be generated in plasma wakefieldaccelerators (PWFA), and then extracted, captured, transported and injected into undulators without quality loss. These ultrabright, sub-femtosecond electron beams can drive hard X-FELs near the cold beam limit to generate coherent X-ray pulses of attosecond-Angstrom class, reaching saturation after only 10 metres of undulator.
This plasma-X-FEL opens pathways for novel photon science capabilities, such as unperturbed observation of electronic motion inside atoms at their natural time and length scale, and towards higher photon energies.
Nanostructural domains in martian apatites that record primary subsolidus exsolution of halogens: Insights into nakhlite petrogenesis
Authors: Martínez Marina , Shearer Charles K. , Brearley Adrian J. 
Published: December 2022

Abstract
The microstructures of selected F-, Cl-, and OH-bearing martian apatite grains, two in Northwest Africa (NWA) 998 (cumulus apatites, embedded in pyroxene) and a set of four in Nakhla (intercumulus apatites), were studied by focused ion beam–transmission electron microscopy (FIB-TEM) techniques. Our results show that the nanostructure of martian apatite is characterized by a domain structure at the 5–10 nm scale defined by undulous lattice fringes and slight differences in contrast, indicative of localized elastic strain within the lattices and misorientations in the crystal. The domain structure records a primary post-magmatic signature formed during initial subsolidus cooling (T &lt;800 °C), in which halogens clustered by phase separation (exsolution), but overall preserved continuity in the crystalline structure. Northwest Africa 998 apatites, with average Cl/F ratios of 1.26 and 2.11, show higher undulosity of the lattice fringes and more differences in contrast than Nakhla apatites (average Cl/F = 4.23), suggesting that when Cl/F is close to 1, there is more strain in the structure. Vacancies likely played a key role stabilizing these ternary apatites that otherwise would be immiscible. Apatites in Nakhla show larger variations in halogen and rare-earth element (REE) contents within and between grains that are only a few micrometers apart, consistent with growth under disequilibrium conditions and crystallization in open systems. Nakhla apatite preserves chemical zonation, where F, REEs, Si, and Fe are higher in the core and Cl increases toward the outer layers of the crystal. There is no evidence of subsolidus ionic diffusion or post-magmatic fluid interactions that affected bulk apatite compositions in NWA 998 or Nakhla. The observed zonation is consistent with crystallization from a late-stage melt that became Cl-enriched, and assimilation of volatile-rich crustal sediments is the most plausible mechanism for the observed zonation. This work has broader implications for interpreting the chemistry of apatite in other planetary systems.
Industrial Tourism Potential of an Old Industrial Region
Authors: Aparina Natal'ya , Kavkaeva Natal'ya 
Published: December 2022

The current crisis in the domestic economy and the tightened international sanctions exacerbate the issue of finding industries that can boost regional development. Tourism is an alternative to traditional industries in an old industrial region. It can rebrand the territory and make an industrial region generate tourist flows. Each old industrial region of the Russian Federation has its own strategies for the development of the tourism industry. Usually, they aim at a total rebranding of their territory, thus rejecting their traditional industrial image. As a result, strategic documents often ignore the touristic potential of old industrial regions. However, industrial tourism can encourage the development of the tourism industry in such regions. The present article introduces some possibilities for the development of industrial tourism in the Kemerovo Region based on consumer preferences. The research methodology relied on an integrated approach to the local touristic resources and involved 160 students of the Kemerovo State University who were asked to assess the attractiveness of the local industrial tourism. The authors used the cluster approach to describe some potential directions for industrial tourism in the Kemerovo Region.
Financial Management of Risks: Multi-Agency Investment Projects
Authors: Vyzhitovich Aleksandr 
Published: December 2022

Effective risk management needs new approaches to risk analysis, especially in multi-agent investment projects. The article focuses on cluster projects currently active in the Novosibirsk Region, as well as on specific financial risks that occur between interacting organizations of various ownership forms. The author studied the assessment methodology for risks that develop as a result of unreliable or incomplete information, violation of state subsidies, their repayment, etc. The analysis of Novosibirsk clusters involved the Kontur. Focus software. The proposed methods included defining key parameters of the control model, procedures for input reliability check, a diagnostic methodology for project members, and integrating the effectiveness of the cluster control system. These approaches and methods can be included in a new integrated approach to the mesolevel risk management of multi-agent cluster projects as part of state and corporate control.
The Effectiveness of Impact of Physical Activity on the Thinking Indicators of School Children
Authors: Polevoy Georgiy Georgievich 
Published: December 2022

Purpose:
The purpose of this study is to determine the influence of physical activity in physical education classes on the thinking indicators of schoolchildren.

Methods:
This was a cross-sectional study conducted in a secondary school number 60 in Kirov (Russia), attended by ninth graders aged 15-16 years (141 schoolchildren). The main method of research was the test “Cross out an extra word”, which determined the level of development of students' thinking. The test was used before and after the physical education lesson 1 time per month for 5 months. Statistical analysis used: The student's T-criterion was used in the study.

Results:
The children who did not exercise, but completed the test, were able to only slightly improve their performance. This trend is observed every month. The indicators improved on average from 2.1% to 4.3% (p>0.05).
The situation is different for children who were engaged in physical education lessons. In each of the five months, the test indicators improved significantly, on average, from 14.2% to 18.8% (p<0.05).

Conclusion:
Physical education likely has a beneficial effect on the thinking of schoolchildren. This study will serve as an additional motivation for children to engage in physical activities, since physical exercises contribute not only to the development of physical qualities, but also to the development of schoolchildren's thinking.
Rebu: Tradisi pantangan suku Karo (Studi etnografi pada suku Karo di kota Medan)
Authors: Ginting Susanto , Harahap Rosmawaty , Wuriyani Elly Prihastuti 
Published: December 2022

Tujuan penelitian ini adalah untuk mendeskripsikan dan menganalisis faktor penyebab pergeseran tradisi rebu pada suku Karo di Kota Medan. Lokasi penelitian adalah Kota Medan. Metode yang digunakan dalam penelitian ini adalah metode pendekatan etnografi. Teori yang digunakan sebagai alat analisis dan dasar pembahasan masalah dalam penelitian ini adalah teori dekonstruksi. Teknik pengumpulan data yang digunakan peneliti adalah observasi, wawancara mendalam, dan dokumentasi. Teknik analisa data adalah dengan menggunakan analisa deskriptif kualitatif dengan pendekatan etnografi. Hasil penelitian menunjukkan bahwa faktor penyebab pergeseran tradisi rebu disebabkan dua faktor. Pertama faktor dari dalam masyarakat sendiri yakni: kurangnya pemahaman terhadap tradisi rebu, kurangnya sosialisasi dalam masyarakat, hilangnya nilai-nilai budaya. Kedua, faktor dari luar masyarakat yakni adanya arus modernisasi dan globalisasi yang mengubah pola pikir, faktor lingkungan yang harus beradaptasi dengan lingkungan tempat tinggal, perkawinan antarsuku atau perkawinan campur, faktor ekonomi untuk memenuhi kebutuhan hidup, dan faktor politik untuk mencapai sesuatu kepentingan politik.Rebu: Tradition of avoiding the Karo tribe (Ethnographic Study of the Karo Tribe in Medan City) The purpose of this study was to describe and analyze the factors causing the shift in the rebu tradition in the Karo Tribe, Medan. This research was conducted in Medan. The method used in this study is an ethnographic approach. The theory used as an analytical tool and the basis for discussing the problem in this study is the theory of deconstruction. Data collection techniques are observation, in-depth interviews, and documentation. The data were then analyzed using a qualitative descriptive analysis with an ethnographic approach. The results showed that the factors causing the shift in the rebu tradition were caused by two factors. First, factors from within the community itself, namely: lack of understanding of the rebu tradition, lack of socialization in society, and loss of cultural values. Second, factors from outside the community, namely the currents of modernization and globalization that change mindsets, environmental factors that must adapt to the environment in which they live, inter-ethnic marriages or mixed marriages, economic factors to meet the needs of life, and political factors to achieve political interests.
Augmented reality-based textbook innovation as learning media for learning from home
Authors: Sartono Kus Eddy , Laisaroh Anggri 
Published: December 2022

Penelitian ini bertujuan menghasilkan buku ajar berbantuan Augmented Reality (AR) yang efektif, valid, dan praktis untuk dimanfaatkan selama BDR di jenjang sekolah dasar. Metode penelitian ini menggunakan Research and Development (RD). Prosedurnya dimulai dari studi literatur, kemudian dilanjutkan dengan perencanaan, penilaian ahli, uji coba lapangan awal, revisi, dan uji coba lapangan utama. Efektivitas buku ajar ditentukan melalui pengujian lapangan, sedangkan validitasnya ditentukan melalui penilaian ahli (ahli materi, ahli bahasa, dan ahli media). Adapun praktikalitasnya ditentukan melalui respon siswa dan respon guru. Pengukuran atas tiga indikator tersebut dilaksanakan di kelas IV SDN Jetisjogopaten, dan SDN Pandowoharjo. Berdasarkan hasil pengukuran, buku ajar berbantuan AR termasuk dalam kategori “layak”. Artinya, buku ajar yang dikembangkan melalui penelitian ini bisa digunakan karena telah memenuhi standar kelayakan menurut ahli, direspon baik oleh guru dan siswa, dan efektif untuk meningkatkan aktivitas dan prestasi belajar siswa kelas IV SD. Atas dasar temuan dan pembuktian di atas, penelitian ini merekomendasikan kepada guru dan orangtua untuk memfasilitasi anak dengan buku ajar berbasis AR sebagai media pembelajaran di rumah.Augmented reality-based textbook innovation as learning media for learning from homeThis research and development aimed to generate effective, valid, and practical Augmented Reality (AR)-assisted textbooks during Learning From Home for the elementary school level. The development procedure started with a literature study, then continued with planning, expert assessment, preliminary field testing, revisions, and primary field testing. The effectiveness of the textbook was determined through field testing, while the validity was determined through expert judgment (experts of material, language, and media). The practicality was determined through the responses of the students and the teachers. This study was carried out in grade IV SDN Jetisjogopaten and SDN Pandowoharjo. AR-assisted textbooks are included in the “feasible” category based on the measurement results. It means that textbooks developed through this study can be used since they meet the eligibility standards according to the expert, are responded to by both teachers and students, and effectively increase fourth-grade elementary school students' activity and learning achievement. Based on the findings and evidence above, this study recommends that teachers and parents facilitate children with AR-based textbooks as learning media.
Investigating students’ on-line exam anxiety and culture on self- efficacy: The moderating role of coping strategy
Authors: Susilowati Nurdian , Latifah Lyna , Mahmud Amir , Aeni Ida Nur , Sari Puji Novita 
Published: December 2022

This study is aimed at examining the moderating role of coping strategy in online exam anxiety and culture on students' self-efficacy. Function-problem-focused coping is the ability of individuals to focus on solving the stress problems they experience during the exam. Meanwhile, emotion-focused coping is the ability of individuals to focus on managing their emotions during online exams. The research population consisted of students of the Faculty of Economics who had taken two years of online learning and online exams. By using the proportionate random sampling technique, a sample of 228 students filled out the google questionnaire form. Data collected were analyzed using Moderated Regression Analysis (MRA). Results show that coping strategy weakens the relationship between anxiety and student self-efficacy during online exams. On the other hand, coping strategy can strengthen the relationship between culture and self-efficacy. In managing coping strategy, students pay attention to function-problem-focused coping and emotion-focused coping. Self-efficacy studies in online exams (in the context of learning outcomes assessment) need to be studied in more detail. Especially now that learning is done virtually, the assessment of learning outcomes plays an important role.