bluuebunny/crossref_metadata_2025_split huggingface dataset:
Virtual Reality for Surgical Planning – Evaluation Based on Two Liver Tumor Resections
Authors: Reinschluessel Anke V. , Muender Thomas , Salzmann Daniela , Döring Tanja , Malaka Rainer , Weyhe Dirk 
Published: February 2022

PurposeFor complex cases, preoperative surgical planning is a standard procedure to ensure patient safety and keep the surgery time to a minimum. Based on the available information, such as MRI or CT images, and prior anatomical knowledge the surgeons create their own mental 3D model of the organ of interest. This is challenging, requires years of training and an inherent uncertainty remains even for experienced surgeons.GoalVirtual reality (VR) is by nature excellent in showing spatial relationships through its stereoscopic displays. Therefore, it is well suited to be used to support the understanding of individual anatomy of patient-specific 3D organ models generated from MRI or CT data. Utilizing this potential, we developed a VR surgical planning tool that provides a 3D view of the medical data for better spatial understanding and natural interaction with the data in 3D space. Following a user-centered design process, in this first user study, we focus on usability, usefulness, and target audience feedback. Thereby, we also investigate the individual impact the tool and the 3D presentation of the organ have on the understanding of the 3D structures for the surgical team.MethodsWe employed the VR prototype for surgical planning using a standard VR setup to two real cases of patients with liver tumors who were scheduled for surgery at a University Hospital for Visceral Surgery. Surgeons (N = 4) used the VR prototype before the surgery to plan the procedure in addition to their regular planning process. We used semi-structured interviews before and after the surgery to explore the benefits and pitfalls of VR surgical planning.ResultsThe participants used on average 14.3 min (SD = 3.59) to plan the cases in VR. The reported usability was good. Results from the interviews and observations suggest that planning in VR can be very beneficial for surgeons. They reported an improved spatial understanding of the individual anatomical structures and better identification of anatomical variants. Additionally, as the surgeons mentioned an improved recall of the information and better identification of surgical relevant structures, the VR tool has the potential to improve the surgery and patient safety.
Finite Element Analysis of Silver Nanorods, Spheres, Ellipsoids and Core–Shell Structures for Hyperthermia Treatment of Cancer
Authors: Daud Muhammad Usama , Abbas Ghulam , Afzaal Muhammad , Naz Muhammad Yasin , Fatima Nazma Goher , Ghuffar Abdul , Irfan Muhammad , Mahnashi Mater H. , Legutko Stanislaw , Petrů Jana , Kratochvíl Jiří , Niazi Usama Muhammad 
Published: February 2022

The finite element analysis technique was used to investigate the suitability of silver nanorods, spheres, ellipsoids and core–shell structures for the hyperthermia treatment of cancer. The temperature of the silver nanostructures was raised from 42 to 46 °C, in order to kill the cancerous cells. The time taken by the nanostructures to attain this temperature, with external source heating, was also estimated. The heat transfer module in COMSOL Multiphysics was used for the finite element analysis of hyperthermia, based on silver nanostructures. The thermal response of different shapes of silver nanostructures was evaluated by placing them inside the spherical domain of the tumor tissue. The proposed geometries were heated at different time intervals. Optimization of the geometries was performed to achieve the best treatment temperature. It was observed that silver nanorods quickly attain the desired temperature, as compared to other shapes. The silver nanorods achieved the highest temperature of 44.3 °C among all the analyzed geometries. Moreover, the central volume, used to identify the thermal response, was the maximum for the silver nano-ellipsoids. Thermal equilibrium in the treatment region was attained after 0.5 μs of heating, which made these structures suitable for hyperthermia treatment.
Low-Temperature Biodegradation of Lignin-Derived Aromatic Model Monomers by the Cold-Adapted Yeast Rhodosporidiobolus colostri Isolated from Alpine Forest Soil
Authors: Margesin Rosa , Ludwikowski Thomas Marek , Kutzner Andrea , Wagner Andreas Otto 
Published: February 2022

The contribution of cold-adapted yeasts to the emerging field of lignin biovalorization has not yet been studied. The red-pigmented basidiomycetous yeast strain Rhodosporidiobolus colostri DBVPG 10655 was examined for its potential to degrade five selected lignin-derived aromatic monomers (syringic acid, p-coumaric acid, 4-hydroxybenzoic acid, ferulic acid, and vanillic acid). The strain utilized p-coumaric acid, 4-hydroxybenzoic acid, and ferulic acid not only as the sole carbon source; full biodegradation occurred also in mixtures of multiple monomers. Vanillic acid was not utilized as the sole carbon source, but was degraded in the presence of p-coumaric acid, 4-hydroxybenzoic acid, and ferulic acid. Syringic acid was utilized neither as the sole carbon source nor in mixtures of compounds. Biodegradation of lignin-derived aromatic monomers was detected over a broad temperature range (1–25 °C), which is of ecological significance and of biotechnological relevance.
Characterization of Actinobacterial Strains as Potential Biocontrol Agents against Macrophomina phaseolina and Rhizoctonia solani, the Main Soil-Borne Pathogens of Phaseolus vulgaris in Cuba
Authors: Díaz-Díaz Miriam , Bernal-Cabrera Alexander , Trapero Antonio , Medina-Marrero Ricardo , Sifontes-Rodríguez Sergio , Cupull-Santana René Dionisio , García-Bernal Milagro , Agustí-Brisach Carlos 
Published: February 2022

Macrophomina phaseolina and Rhizoctonia solani are considered two major soil-borne pathogens of Phaseolus vulgaris in Cuba. Their management is difficult, not only due to their intrinsic biology as soil-borne pathogens, but also because the lack of active ingredients available against these pathogens. Actinobacteria, a heterogeneous bacterial group traditionally known as actinomycetes have been reported as promising biological control agents (BCAs) in crop protection. Thus, the main objective of this study was to evaluate the effectiveness of 60 actinobacterial strains as BCAs against M. phaseolina and R. solani in vitro by dual culture assays. The most effective strains were characterized according to their cellulolytic, chitinolytic and proteolytic extracellular enzymatic activity, as well as by their morphological and biochemical characters in vitro. Forty and 25 out of the 60 actinobacteria strains inhibited the mycelial growth of M. phaseolina and R. solani, respectively, and 18 of them showed a common effect against both pathogens. Significant differences were observed on their enzymatic and biochemical activity. The morphological and biochemical characters allow us to identify all our strains as species belonging to the genus Streptomyces. Streptomyces strains CBQ-EA-2 and CBQ-B-8 showed the highest effectiveness in vitro. Finally, the effect of seed treatments by both strains was also evaluated against M. phaseolina and R. solani infections in P. vulgaris cv. Quivicán seedlings. Treatments combining the two Streptomyces strains (CBQ-EA-2 + CBQ-B-8) were able to reduce significantly the disease severity for both pathogen infections in comparison with the non-treated and inoculated control. Moreover, they showed similar effect than that observed for Trichoderma harzianum A-34 and with Celest® Top 312 FS (Syngenta®; Basilea, Switzerland) treatments, which were included for comparative purposes.
Direct electrospray patterning deposition for flexible organic devices
Authors: Kanno Ayaka , Moriwaki Takahisa , Yamauchi Hiroshi , Tadokoro Takashi 
Published: February 2022

Abstract
Organic electronic devices are attracting much attention because of their ease of thin-film processing such as inkjet printing. In general, the electrospray deposition (ESD) method is useful for forming uniform thin films. In the present study, we propose a new direct-patterning ESD method in which an electric field is applied between a syringe needle and a patterned counter electrode. Patterned organic semiconductor films were formed on flexible insulator substrates overlying the counter electrodes. In addition, we show that the width of the patterned organic film could be controlled by varying the applied electric field between the syringe needle and counter electrode.
Clinical and morphological aspects of the combination of tuberculosis and lung cancer
Authors: Stogova Natalia 
Published: February 2022

The purpose of the study. To establish the features of clinical and radiological manifestations of the disease and the effectiveness of methods of examination of patients with a combination of lung cancer and tuberculosis.
Material and methods. The analysis of the case histories of 38 lung cancer patients aged 42 to 82 years, 31 men and 7 women who were in the Voronezh regional tuberculosis dispensary in 1995–2019 was carried out. In 20 patients, cancer was combined with active pulmonary tuberculosis (group 1) and in 18 patients with inactive residual changes in the lungs after earlier tuberculosis (group 2). Research methods: clinical, laboratory, instrumental, morphological, statistical using the SPSS Statistics 10 program.
Results. In group 1, focal pulmonary tuberculosis in the infiltration phase was detected in 2 (10.0%), infiltrative tuberculosis — in 18 (90.0%) patients. Central lung cancer was found in 12 (60.0%), peripheral — in 8 (40.0%) patients. Lung cancer was detected in stage I in 5 (25.0%), in stage II in 6 (30.0%), in stage III in 4 (20.0%) and in stage IV in 5 (25.0%) patients. In group 2, central lung cancer was detected in 7 (38.9%), peripheral lung cancer in 11 (61.1%) patients. Lung cancer was detected in stage I in 3 (16.7%), in stage II in 2 (11.1%), in stage III in 3 (16.7%) and in stage IV in 10 (55.5%) patients.
Conclusion. The combination of lung cancer and tuberculosis is more often observed in men, more often in the elderly and senile age. Cancer occurs in the lung on the side of the tuberculous lesion with active tuberculosis in 75.0%, with inactive — in 83.3% of cases. Microbiological and morphological methods of investigation are the most effective for verifying the diagnosis of a combination of tuberculosis and lung cancer.
New Determinations of the Rotational Periods of 78 Vir (A2p SrCrEu) and 52 Her (A1p SiSrCr)
Authors: Monier Richard , Mary David 
Published: February 2022

Abstract
The TESS lightcurves of the two cool Ap stars, 78 Vir and 52 Her, are used to derive new rotational periods for both stars. A frequency analysis of the light curve of 52 Her with the Generalized Lomb–Scargle periodogram reveals a periodic structure with three harmonics. The inverse of the fundamental frequency yields a rotational period of 3.840 ± 0.037 days for 52 Her. The same analysis for 78 Vir yields two harmonics with a rotation period of 3.718 ± 0.037 days, only slightly shorter than previous determinations.
Methane-saturated Layers Limit the Observability of Impact Craters on Titan
Authors: Wakita 脇田 Shigeru 茂 , Johnson Brandon C. , Soderblom Jason M. , Shah Jahnavi , Neish Catherine D. 
Published: February 2022

Abstract
As the only icy satellite with a thick atmosphere and liquids on its surface, Titan represents a unique end-member to study the impact cratering process. Unlike craters on other Saturnian satellites, Titan’s craters are preferentially located in high-elevation regions near the equator. This led to the hypothesis that the presence of liquid methane in Titan’s lowlands affects crater morphology, making it difficult to identify. This is because surfaces covered by weak fluid-saturated sediment limit the topographic expression of impact craters, as sediment moves into the crater cavity shortly after formation. Here we simulate crater-forming impacts on Titan’s surface, exploring how a methane-saturated layer overlying a methane-clathrate layer affects crater formation. Our numerical results show that impacts form smaller craters in a methane-clathrate basement than a water-ice basement due to the differences in strength. We find that the addition of a methane-saturated layer atop this basement reduces crater depths and influences crater morphology. The morphology of impact craters formed in a thin methane-saturated layer is similar to that in a “dry” target, but a thick saturated layer produces an impact structure with little to no topography. A thick methane-saturated layer (thicker than 40% of the impactor diameter) could explain the dearth of craters in the low-elevation regions on Titan.
Critical Care Problem in a Case of Intracerebral Hemorrhage Due to Eclampsia and Its Ethics and Medicolegal Consideration
Authors: Kulsum Kulsum , Suryadi Taufik 
Published: February 2022

BACKGROUND: Eclampsia accompanied by hemolysis elevated liver enzymes low platelet (HELLP) syndrome is an emergency condition during late trimester pregnancy characterized by hypertension, seizures, and coma. Obstetric history is known that the patient does not conducted antenatal care regularly to the doctor so that the patient does not know she has eclampsia. One of which complications due to eclampsia is intracerebral hemorrhage which is a major cause of death and morbidity in pregnant woman. This case report discusses how ethical and medicolegal decision-making for procedures to withholding or withdrawing life support for the critical care problem. The ethical dilemma faced by neuroanesthesia and critical care (NACC) consultants is whether to continue to treat patients in the intensive care unit (ICU) even though the results will be in vain or to restrict critical care because they concluded that the condition of the patient has a terminal stage.

CASE REPORT: A reported case of a 23-year-old woman, pregnant, and had a caesarian section for the indication of eclampsia accompanied by HELLP syndrome in rural hospital. Because the patient’s condition worsened, she was referred to Zainoel Abidin hospital due to decrease in consciousness and a computed tomography scan of the head showed extensive bleeding. The results of the neuroanesthesia and neurosurgery team’s assessment stated that there was no indication of surgery on the patient because extensive bleeding had occurred accompanied by brain edema. The patient then undergoes treatment in the ICU to improve the patient’s critical condition. In an effort to overcome this problem, the NACC consultant consults with an ethics and medicolegal consultant as a representation of the medical committee and ethical committee to determine the withholding or withdrawing of life support therapy to the patient.

CONCLUSION: Life support therapies that can be withhold or withdraw are simply an extraordinary treatment that provides no benefit. The basic principles of ethics in making decisions to do withholding and withdrawing life support in these patients are beneficence and non-maleficence, while the medicolegal principle in these patients lies in the patient’s condition being medically incurable (terminal state) and medical treatment is useless (futile treatment).
Clinical Forensic Evidence in Gunshot Wounds through Anesthesia and Surgical Procedures: A Case Report
Authors: Suryadi Taufik , Kulsum Kulsum , Simatupang Ari Putra , Rahmatillah Irhamni , Mentari Putri , Fathima Raisha 
Published: February 2022

BACKGROUND: Clinical forensic evidence of live victims with gunshot wounds can be supported by anesthesia and surgical procedures. Gunshot wounds are a complex and traumatic type of wound that are commonly found in forensic practice, most of which can cause death. Injuries to gunshot wounds are caused by the penetration of a projectile into the body that is ejected from the barrel of a gun due to the burning of gunpowder from the bullet. Using anesthetic procedures and thoracic surgery can help prove the victim's gunshot wound. Medical evidence in the form of bullet projectiles found on the victim's body can be used as legal evidence. So it can be said that anesthesia and thoracic surgery procedures can be one of the modalities of clinical forensic examination in proving the existence of a criminal event. CASE REPORT: The method of this study was a case report. A 58-year-old male victim was shot in the left back. Forensic examination of the victim showed a gunshot wound to the left side of the back about the 11th thoracic vertebra, round or oval in shape, accompanied by seams of abrasions around the wound, no seams of tattoos, soot or fire were found and not accompanied by a gunshot wound. Based on the results of the radiographic examination of the posteroanterior and lateral chest radiographs, two cylindrical radio-opaque images were found in the left hemithorax. During anesthesia and thoracic surgery, a foreign body was found in the left thoracic wall region, as well as lacerations in the left inferior lobe of the lung. Clinical forensic evidence in gunshot wounds has been successfully carried out using anesthesia and surgical procedures. The evidence was also reviewed from the radiological examination which proved the existence of bullet projectiles by virtual imaging. CONCLUSION: Clinical forensic evidence of course continues to evolve in accordance with advances in medical technology. The better the proof method, the easier it is to find the desired evidence. Anesthesia and surgical procedures can be used as an alternative to forensic evidence in clinical cases.
Mineurs incarcérés
Authors: Varnoux Aurélien , Monod Guillaume 
Published: February 2022

Les soins pédopsychiatriques se déploient en détention avec des moyens insuffisants. La politique pénale des mineurs soutient les réponses éducatives avant tout, mais on dénombre environ huit cents mineurs incarcérés en France. Il ne sera pas dit que le travail éducatif n’est pas possible en détention ni que le travail psychothérapique sous contrainte soit une incohérence ! La pédopsychiatrie en milieu carcéral ne donne pas à voir une clinique singulière, mais permet de recevoir des mineurs difficiles à rencontrer en consultation ambulatoire. Des approches originales doivent être consolidées pour répondre à l’expression comportementale et corporelle de la souffrance psychique de ces mineurs. Enfin, la coordination des interventions est un point de vigilance majeur.
Du « cas de Gaël » à Pauline : vers un défi pédagogique et didactique pour une éducation plus inclusive ?
Authors: Priolet Maryvonne 
Published: February 2022

Cette étude vise à mettre en parallèle, à quelque trente années d’écart, la prise en charge dans une classe ordinaire d’école élémentaire d’une élève relevant d’un dispositif Ulis école et celle du « cas de Gaël » décrite par Brousseau. L’analyse de l’observation in situ d’une séance de résolution de problèmes suivie d’un entretien avec l’enseignante révèle les choix effectués pour inclure cette élève, mais aussi les difficultés rencontrées par l’enseignante de la classe pour passer du concept d’intégration à celui d’inclusion. Cette analyse conduit à envisager les apports dont pourrait bénéficier l’ensemble du groupe-classe dans le contexte de l’inclusion scolaire.
EFFICACY AND SAFETY OF SINOPHARM VACCINE FOR SARS-COV-2 AND BREAKTHROUGH INFECTIONS IN IRANIAN PATIENTS WITH HEMOGLOBINOPATHIES: A PRELIMINARY REPORT
Authors: Karimi Mehran , Zarei Tahereh , Haghpanah Sezaneh , Azarkeiva Azita , Naderi Maryam , Matin Sara , Bazrafshan Asghar , Zahedi Zohreh , Shirkavand Afshan , Pishdad Parisa , De Sanctis Vincenzo 
Published: February 2022

Background: The ongoing COVID-19 pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has led to high morbidity and mortality worldwide. Vaccination against SARS-CoV-2 is a leading strategy to change the course of the COVID-19 pandemic.
Aims of study: Our aim was to investigate the efficacy and side effects of Sinopharm vaccine in patients with hemoglobinopathies in Iran, and the frequency of breakthrough infection after a full course of vaccination.
Methods: A multicenter cross-sectional study of 434 patients with hemoglobinopathies (303 β-thalassemia major, 118 β-thalassemia intermedia, and 13 sickle-thalassemia) were conducted from March to July 2021 in IRAN. All patients have received the first dose of China Sinopharm vaccine and received the second dose of the vaccine 28 days apart.
Antibody testing: Detection of immunity after vaccination was evaluated by commercial enzyme-
linked immunosorbent assay (Pishtazteb ELISA commercial kit), including a surrogate virus
neutralization test (sVNT), for detection of SARS-CoV-2 immunoglobulins (IgA, IgM, IgG), total neutralizing antibody (NAb).
Results: The mean age of patients was 35.0± 8.5 (from 18 to 70) years and 55.6% were positive for antibody. Overall, 48.2% of the studied population had at least one side effect after vaccination. The most frequent side effects were fever and chills, dizziness, and body pain. A total of 90 (20.7%) vaccinated patients developed breakthrough infections after full Sinopharm vaccination. Disease severity was recorded, and it was classified as mild in 77.8%, moderate in 13.6%, and severe in 7.4% of patients. One 28-year-old woman with β- thalassemia major died eight days after the diagnosis of breakthrough SARS-CoV-2 infection.
Discussion: No safety concerns were identified in patients who received two doses of Sinopharm vaccine. Its efficacy was not optimal which might be due to lack of its effect on new variations of virus. However, our data show that it can prevent from severity of COVID-19 infection in patients with hemoglobinopathies. The frequency of breakthrough infections after full Sinopharm vaccination support the evolving dynamic of SARS-CoV-2 variants requiring special challenge, since such infection may represent a risk for vulnerable patients.