bluuebunny/crossref_metadata_2025_split huggingface dataset:
Value of routine blood count surveillance in detecting relapse in acute lymphoblastic leukemia
Authors: AlHarbi Sarah , Taha Areej , Ashi Ahmed , Elimam Naglla , Althubaiti Sami 
Published: January 2025

BackgroundChildren with acute lymphoblastic leukemia (ALL) have excellent outcomes, with &gt;85% survival without relapse following contemporary therapies. Clinical and complete blood count (CBC) assessments are commonly used surveillance methods to detect relapses. We aimed to evaluate the efficacy of routine blood testing for detecting relapse using a systematic method of assessing normal and abnormal results.MethodsThis a retrospective, single center study included children aged 1–14 years diagnosed with ALL who completed therapy and were in complete remission. Demographic data, leukemia subtypes, risk stratification, treatment responses, and outcomes were also reviewed. CBC tests were evaluated, and abnormal results were categorized. The relapse groups were classified as asymptomatic and symptomatic relapses. The clinical outcomes of relapse and complications were analyzed. The sensitivity, specificity, positive predictive value, and negative predictive value of surveillance laboratory tests for predicting relapse after the end of treatment were evaluated.ResultsIn total, 187 patients underwent 2074 CBC tests. Ten patients underwent full surveillance, whereas the remaining patients underwent partial surveillance. The median number of surveillance blood draws per patient was 12. Relapse was observed in nine patients. Only three patients had asymptomatic relapses. Neutropenia, leukopenia, pancytopenia, thrombocytopenia, and anemia were observed in 98, 89, 10, 6, and 3 patients respectively. The sensitivity and specificity of neutropenia, leukopenia, thrombocytopenia, anemia, and pancytopenia were 11.11% and 47.9%, 0% and 50%, 33.3% and 98.31%, 0% and 99.4%, and 33.3% and 96.07%, respectively. No differences were observed between patients who had asymptomatic relapses and those whose clinical outcomes or consequences had symptomatic relapses.ConclusionRelapse after completion of therapy in ALL is rare. Regular blood count surveillance does not predict clinical outcomes or relapse. Prospective studies are required to assess appropriate risk-based surveillance and its effects on patient outcomes and quality of life.
Association of breast milk microbiota and metabolites with neonatal jaundice
Authors: Liu TianYu , Yuan Yanhan , Wei Jinying , Chen Jiayi , Zhang Feng , Chen Juanjuan , Zhang Jinping 
Published: January 2025

BackgroundBreast milk is the primary source of nutrition during early life, and existing research indicates that the development of jaundice in breastfed newborns may be linked to specific nutrients or bioactive substances present in breast milk. However, the association between the microbiota and small-molecule metabolites in breast milk and the development of neonatal jaundice remains unproven. This study aimed to investigate the development of jaundice in breastfed neonates in relation to breast milk microbiota and metabolites.MethodsBased on the conditions of exclusive breastfeeding, we selected healthy newborns without significant jaundice and their mothers on day 4 (96–120 h after birth) as the healthy control group, and jaundiced newborns and their mothers as the jaundice group. Breast milk samples were collected from mothers in both groups on postnatal day 4 and analyzed for microbiota and small-molecule metabolites using 16S rRNA gene sequencing and an liquid chromatography-tandem mass spectrometry techniques.ResultsA total of 104 mother-child pairs were included in the study, of which 51 pairs were in the healthy control group and the other 53 pairs were in the jaundice group. Our results demonstrated that there was no significant difference between the species composition and diversity of the breast milk flora in the healthy control and jaundice groups. At the genus level, the abundance of Lactobacillus, Ackermannia, and Bifidobacterium was significantly higher in the breast milk of the healthy control group than in the jaundice group. Metabolomics analysis revealed a total of 27 significantly different metabolites between the two groups. Notably, breast milk from the healthy control group had elevated levels of 24 metabolites, predominantly lipids family, including sphingolipids, phospholipids, and fatty acid derivatives.ConclusionThis study suggests that there is a link between the development of neonatal jaundice and breast milk microbiota and metabolites. Breast milk from mothers of healthy newborns contains higher levels of beneficial bacteria and lipid family compared to mothers of newborns with jaundice. This study offers new insights into the relationship between breastfeeding and neonatal jaundice.
Effects of basic type of intermittent exotropia on myopic shift in children: a 12-month observational study
Authors: Li Jing-Xin , Liu Xiang-Xiang , Hao Jie , Li Hui-Xin , Zhang Qiong-Yue , Zhao Yi-Yang , Wang Yu-Meng , Li Lei , Fu Jing 
Published: January 2025

BackgroundTo investigate the effect of basic intermittent exotropia (IXT) on myopic shift in children during 12-month follow-up.Methods165 children aged 4–15 years were recruited prospectively in this study and divided into 3 groups: Group A, consisted of 64 patients with basic IXT without surgery; Group B, consisted of 51 patients 1-month after IXT-corrected surgery; and Group C, consisted of 50 patients without any form of strabismus. All patients underwent assessments of spherical equivalent (SE), axial length (AL), exodeviation, and binocular function relating to accommodation and convergence. Examinations were conducted at baseline and 12-month. SE and AL changes were compared among groups. Univariate and multivariate linear analyses were employed to investigate the association between myopic shift and IXT, as well as other clinical parameters.ResultsThree groups showed comparable ages, genders and SEs at baseline (all P &gt; .05). During 12-month follow-up, the rate of myopic shift varied among groups. Significant differences in SE progression (P = .006) and AL elongation (P = .014) between Group A and Group C were observed. Although SE progression and AL elongation in Group B were less than Group A, no significant differences were found (P = .125; P = .038). In the multivariate analysis, increases in exodeviation angle were significantly associated with both SE progression (β = 0.010, P = .041) and AL elongation (β = −0.005, P = .026). Each one prism diopter increase in the exodeviation angle was correlated with a 0.01D SE progression and a 0.005 mm AL elongation.ConclusionsChildren with basic IXT exhibited faster myopia shift compared to those without strabismus. Although surgical correction of strabismus appeared to slow this process, the effect was not statistically significant. Furthermore, greater increase in exodeviation angle was associated with higher rate of SE progression and AL elongation.
Trial registrationThe study was approved by the Ethics Committee of Beijing TongRen Hospital (approved number: TRECKY2020-142, approved date: 2020.10.30).
Drug-induced urinary retention: a real-world pharmacovigilance study using FDA and Canada vigilance databases
Authors: Dai Xianyu , Yu Kai , Chang Yu , Hou Yuchuan 
Published: January 2025

BackgroundUrinary retention (UR) is a clinical condition where patients cannot fully empty their bladder. Although numerous drugs are associated with UR, comprehensive and reliable studies identifying drugs that induce UR are scarce.MethodsThis study leveraged data from the FDA Adverse Event Reporting System (FAERS) and the Canadian Vigilance Adverse Reaction (CVAR) database to explore adverse events (AEs) related to UR from 2004 to Q1 2024. The top 50 drugs were analyzed for annual reporting trends using linear regression. Disproportionality analysis using the reporting odds ratio (ROR) method, with P-values adjusted via Bonferroni correction, identified significant signals, which were then validated against drug labels and re-evaluated using the CVAR database. Time-to-onset analysis was also performed.ResultsFrom 2004 to Q1 2024, FAERS recorded 17,785,793 AEs, with 16,183 (0.09%) identified as UR cases. The median age among these cases was 65 years, with males comprising 53.4%. There were significant annual increases in UR reports associated with antineoplastic agents (0.19% per year) and antidiabetic drugs (0.09% per year), while reports linked to bronchodilators decreased (−0.53% per year). Disproportionality analysis revealed significant signals for 34 drugs (68%), with the highest RORs observed in Fesoterodine, Mirabegron, and Solifenacin. Initial signal detection identified potential new UR signals for Abiraterone, Valacyclovir, Fluoxetine, Empagliflozin, Clopidogrel, and Amlodipine, with CVAR confirming signals for Abiraterone, Fluoxetine, and Empagliflozin. The median time to onset of UR was 29 days, with over half of the cases occurring within 30 days of initiating medication.ConclusionThe study identifies a rising trend in drug-related UR reports over the past 2 decades. The validation of new signals for Abiraterone, Fluoxetine, and Empagliflozin underscores the critical need for continuous drug safety monitoring and targeted research to better understand the mechanisms behind drug-induced UR.
A study to assess the pharmacological agent potential of gold nanoparticles and their effects on human cancer cells and hospital pathogens using in vitro methods
Authors: Baran Ayşe 
Published: January 2025

Interest in metal nanoparticles synthesised using green methods is growing steadily. Metal nanoparticles can be synthesised inexpensively and effortlessly using extracts derived from different plants and their diverse components. Gold nanoparticles (Au NPs) were rapidly synthesised from Broccoli (Brassica oleracea L.) agricultural waste using a novel, cost-effective, and eco-friendly method in this work. Analysed data from various techniques including UV-vi, TEM, FESEM, XRD, AFM, FTIR, TGA-DT, EDX, and DLS to assess the properties of the synthesised Au NPs. The characterisation data revealed that the Au NPs had a peak absorbance at 553.10 nm, a surface charge of −19.7 mV, an average hydrodynamic size of 78.75 nm, a monodisperse spherical shape, and were found to be stable. The inhibitory effects of Au NPs with these properties on hospital pathogens and human cancer cells were evaluated by microdilution, disk diffusion and MTT techniquesAs a result of the findings, it was determined that Au NPs have antibacterial, antifungal and anticancer potential as pharmacological agents under in vitro conditions.
Curcumin nanocrystals ameliorate ferroptosis of diabetic nephropathy through glutathione peroxidase 4
Authors: Xue Mengjiao , Tian Yiwei , Zhang Hua , Dai Shijie , Wu Yangsheng , Jin Juan , Chen Jian 
Published: January 2025

ObjectiveThe aim of this study was to investigate the effect of curcumin nanocrystals (Cur-NCs) on ferroptosis in high-glucose (HG)-induced HK-2 cells and streptozotocin (STZ)-induced diabetic nephropathy model (DN) rats. The purpose is to determine whether Cur NCs can become a promising treatment option for diabetes nephropathy by reducing ferroptosis.MethodsCur-NCs were prepared using microfluidic technology and studied using dynamic light scattering and transmission electron microscopy. HK-2 cells were treated with 30 mM HG to create a renal tubule damage cell model. Then, cell viability was evaluated in HK-2 cells treated with varying concentrations of Cur-NCs (0.23, 0.47, 0.94, 1.87, 3.75, 7.5, 15, and 30 μg/mL) using Cell Counting Kit-8 (CCK-8). Furthermore, in vivo experiments were carried out to investigate the roles of Cur-NCs in STZ-induced DN rats.ResultsThe results showed that HG treatment greatly enhanced the levels of LDH, MDA, Iron, lipid ROS, apoptosis, NCOA4, TFR-1, while decreasing the expression of GSH, GPX4, SLC7A11, and FTH-1. These effects induced by HG could be attenuated by Cur-NCs. Cur-NCs also reduced the HG-induced decrease in cell viability, as well as the increase in lipid ROS and cell apoptosis, however erastin could inhibit their effects. Furthermore, the in vivo results showed that Cur-NCs reduced ferroptosis and inhibited renal damage in DN rats.ConclusionThis study demonstrates that Cur-NCs can significantly attenuate ferroptosis in a STZ-induced renal damage model by recovering GPX4, implying that Cur-NCs may be a promising therapy option for DN.
The impact of different exercise modalities on chronic kidney disease: an umbrella review of meta-analyses
Authors: Correa Hugo L. , Rosa Thiago S. , Santos Rafael L. , Mestrinho Vitoria M. , Aquino Thaís S. , Santos Weberth O. , Neves Rodrigo P. , Deus Lysleine A. , Reis Andrea L. , Barbosa Jessica M. , Araujo Thais B. , Verhoeff Ruchama , Yatim Karim , Mendes Daniel , Manfro Roberto C. , Borges Thiago J. , Riella Leonardo V. 
Published: January 2025

IntroductionExercise is widely recognized for its benefits to chronic kidney disease (CKD) patients. However, the specific impact of different exercise modalities on CKD-related outcomes remains unclear. This study sought to summarize the effects of different exercise modalities on the main outcomes impacted by CKD.MethodsWe searched for systematic review with meta-analysis in PubMed, Embase, Web of Science, Scopus, and Cochrane databases. We evaluated the methodological quality of included studies by AMSTAR2 tool and by individually evaluating the heterogeneity, sample power, and statistical significances from meta-analyses.ResultsWe included 44 meta-analyses, encompassing 35,432 CKD patients in pre-dialysis and dialysis stages (peritoneal and hemodialysis). Data from meta-analyses with highly suggestive or strong evidence grading suggests that aerobic and combined training were most effective in improving cardiorespiratory fitness (main effect: 2.1, 95% CI: 0.8–3.4, and main effect: 3.4; 95% CI: 2.4–4.6, respectively). Combined training showed a consistent benefit in psychosocial domains (main effect: −7.3; 95% CI: −9.31 to −53). All exercise modalities significantly improve functional performance, except isometric training, which impacted just fistula maturation (main effect: 0.84; 95% CI: 0.5–1.2).ConclusionExercise emerges as a potential non-pharmacological therapy for CKD patients. Tailoring exercise to specific outcomes appears to be crucial, as different exercise modalities exhibit varying effectiveness.
Characterization of the ligand-binding properties of odorant-binding protein 38 from Riptortus pedestris when interacting with soybean volatiles
Authors: Guo Jianglong , Liu Panjing , Zhang Xiaofang , An Jingjie , Li Yaofa , Zhang Tao , Gao Zhanlin 
Published: January 2025

BackgroundRiptortus pedestris (Fabricius) (Hemiptera: Alydidae) is a major soybean pest throughout East Asia that relies on its advanced olfactory system for the perception of plant-derived volatile compounds and aggregation pheromones for conspecific and host plant localization. Odorant binding proteins (OBPs) facilitate the transport of odorant compounds across the sensillum lymph within the insect olfactory system, enabling their interaction with odorant receptors (ORs).MethodsReal-time quantitative PCR (qRT-PCR) analyses, fluorescence-based competitive binding assays, and molecular docking analyses were applied to assess the expression and ligand-binding properties of OBP38 from R. peddestris.ResultsThe qRT-PCR analyses revealed high levels of RpedOBP38 expression in the antennae without any apparent sex bias, and it was also highly expressed in the adult stage. Recombinant RpedOBP38 was prepared by expressing it in E. coli BL21 (DE3) followed by its purification with a Ni-chelating affinity column. RpedOBP38 was found to bind most strongly to trans-2-decenal (Ki = 7.440) and trans-2-nonenal (Ki = 10.973), followed by β-pinene, (+) -4-terpineol, carvacrol, methyl salicylate, and (-)-carvone. The 3D structure of RpedOBP38 contains six α-helices and three interlocked disulfide bridges comprising a stable hydrophobic binding pocket. In a final series of molecular docking analyses, several polar (e.g., His 94, Glu97) and nonpolar (e.g., Leu29, Ile59) residues were found to be involved in RpedOBP38-ligand binding.ConclusionThese data support a role for RpedOBP38 in the perception of volatiles derived from host plants, providing important insight into the mechanisms that govern olfactory recognition in R. pedestris, thereby informing the development of ecologically friendly approaches to managing R. pedestris infestations.
The effect of text and graphic cue-based action observation on the working memory performance of novice badminton players
Authors: Jang Dukchan , Ha Junho 
Published: January 2025

IntroductionUnderstanding strategic situations is essential in sports. There has been relatively little research examining the effectiveness of action observation based on visual cues in strategic situations. This study investigated whether action observation with visual cues can help performers understand the strategic aspects of complex sports by analyzing the effect of text cue-based action observation and graphic cue-based action observation on the accuracy and speed of cognitive information processing in working memory.MethodsForty-four male and female novice badminton players participated in the experiment. They were randomly assigned to one of four groups: text cue-based action observation (TAO), graphic cue-based action observation (GAO), action observation (AO), and a control group (CON). The experimental design consisted of a pre-test, intervention, and post-test. The experiment analyzed the accuracy and response time of cognitive information processing in working memory.ResultsThe accuracy and response time analysis showed that the AO group significantly improved their cognitive performance accuracy and response time from pre-test to post-test compared to the control group. The TAO and GAO groups with visual cues significantly outperformed the AO and CON groups for accuracy. However, only the TAO group significantly outperformed the other groups in term of response time. The GAO group improved significantly compared to the CON group but not significantly compared to the AO.ConclusionThese results suggest that visual cues can influence the modulation of cognitive load in working memory and that TAO is a relatively more efficient perceptual-cognitive training method for novices.
The effect of repetitive and Deep Transcranial Magnetic Stimulation on quantitative electroencephalography in major depressive disorder
Authors: Ilhan Reyhan , Arikan Mehmet Kemal 
Published: January 2025

BackgroundF-8-coil repetitive transcranial magnetic stimulation (rTMS) and H-1-coil deep repetitive transcranial magnetic stimulation (dTMS) have been indicated for the treatment of major depressive disorder (MDD) in adult patients by applying different treatment protocols. Nevertheless, the evidence for long-term electrophysiological alterations in the cortex following prolonged TMS interventions, as assessed by quantitative electroencephalography (qEEG), remains insufficiently explored. This study aims to demonstrate the qEEG-based distinctions between rTMS and dTMS in the management of depression and to evaluate the potential correlation between the electrophysiological changes induced by these two distinct TMS interventions and the clinical improvement in depressive and anxiety symptoms.MethodsA total of 60 patients diagnosed with treatment resistant depression received rTMS (n = 30) or dTMS (n = 30) along with their usual treatments in Kemal Arıkan Psychiatry Clinic. All the participants underwent resting-state qEEG recording before and at the end of 30 sessions of TMS treatment. The significant qEEG changes were then tested for their correlation with the improvement in depression and anxiety.ResultsAfter the course of rTMS and dTMS a considerable reduction is seen in the severity of depression and anxiety. Although improvements in depression and anxiety were observed in both TMS groups, specific neural activity patterns were associated with better outcomes in depression. Patients who exhibited lower alpha activity in the left fronto-central region and higher gamma activity in the right prefrontal region following rTMS showed more significant improvements in depression symptoms. Similarly, those whose beta activity increased in the left prefrontal region but decreased in the right prefrontal region after rTMS tended to have greater reductions in depression and anxiety severity. For patients in the dTMS group, those who demonstrated a decrease in left temporal theta activity after treatment were more likely to experience a substantial improvement in depression severity.ConclusionFollowing 30 sessions of rTMS with a F8 coil and dTMS with an H1 coil, notable alterations in qEEG activity with clinical significance were discerned. The persistence of these changes should be investigated in the subsequent follow-up period.
A meta-analysis of the relationship between anxiety and non-suicidal self-injury based on knowledge graphs
Authors: Shi Jieyao , Gao Pan , Zhou Bingqian , Huang Zhisheng 
Published: January 2025

ObjectiveThe existing research on the relationship between anxiety and non-suicidal self-injury (NSSI) is inconsistent, and there is no systematic review on this area. This study aims to explore the relationship between anxiety and NSSI, in order to provide evidence-based medicine evidence for the early identification of preventable occurrence factors of NSSI.MethodsThe semantic query (i.e. SPARQL) method was used to retrieve the anxiety- related literature on the Knowledge graph of NSSI, which consist of the metadata and semantic annotation data of English literature related to non-suicidal self-injury in PubMed by June 2023. Two researchers strictly followed the inclusion and exclusion criteria for independent literature screening. After evaluating the quality of the included studies, the selected data was subjected to meta-analysis using RevMan5.3 software.ResultsA total of 14 studies met the inclusion criteria of the meta-analysis, including 44064 subjects. The results showed that the proportion of anxiety in the NSSI group was significantly higher than that in the non-NSSI group, and the difference between the groups was statistically significant (OR=3.60, 95% Cl=2.08-6.22, p&lt;0.01).ConclusionThere is a significant correlation between anxiety and NSSI, which is a possible risk factor for NSSI. However, due to limitations of the design type, quantity, and quality of the included study, further research is needed on the causal relationship between anxiety and NSSI. Furthermore, we show that using knowledge graphs is an effective approach to retrieve literature for meta-analysis.