bluuebunny/crossref_metadata_2025_split huggingface dataset:
Heart transplantation in children and adults with Down syndrome: A single centre experience
Authors: Khoshbin Espeed , Khushnood Abbas , Reinhardt Zdenka , Parry Gareth , Schueler Stephan , Hasan Asif 
Published: August 2022

AbstractBackgroundIn recent years, rapid advances in cardiac surgery and changes in attitude towards patients with cognitive disability have led to these patients receiving cardiac transplantation.MethodThis is a retrospective report describing the experience of four patients with Down Syndrome who received heart transplantation in a single institution.ResultsAnthracycline‐induced cardiomyopathy was the most common cause of heart failure in this group (3/4). Two patients were bridged to transplantation, one by using a combination of extra‐corporeal membrane oxygenation and biventricular assist device and the other by using a durable implantable left ventricular assist device. All the four patients are alive with the longest surviving patient 17 years after transplantation. Against strong hypothetical predictions, we observed no propensity for the development of post‐transplant infections or lymphoproliferative disorders.ConclusionDown Syndrome should not be the sole contraindication to heart transplantation. The decision for transplantation should be on a case‐by‐case basis provided adequate social support is in place.
Cryotherapy in the paediatric airway: Indications, success and safety
Authors: Schramm Dirk , Freitag Nadine , Kötz Karsten , Iglesias‐Serrano Ignacio , Culebras‐Amigo Mario , Koblizek Vladimir , Pérez‐Tarazona Santiago , Cases Viedma Enrique , Srikanta JT , Durdik Peter , Darwiche Kaid , Rubak Sune , Stafler Patrick 
Published: August 2022

AbstractBackground and objectiveCryotherapy in interventional bronchoscopy is a new treatment modality, which has recently been made available for the paediatric airway. Lack of experience and safety concerns have led to hesitant adaptation. The aim of this study was to assess indications, success rates and complications of airway cryotherapy in children.MethodsBronchoscopists from medical centre performing cryotherapy in patients between 0 and 18 years were invited to participate in a prospective study based on an online questionnaire. Patient and participant data were collected between June 2020 and June 2021.ResultsA total of 69 cryotherapy procedures were performed in 57 patients a for three main indications: Biopsy (30), restoration of airway patency (23) and foreign body aspiration (16). The overall success rate was 93%, the remaining 7% were performed for foreign body removal and required a switch of technique. Restoration of airway patency was successfully applied in various pathologies, including mucus plugs, bronchial casts and post traumatic stenosis. The diagnostic yield of transbronchial biopsies was 96%. No severe complications were encountered; one pneumothorax following a cryobiopsy required a chest drain for 48 h. No child was admitted to intensive care or died from a procedural complication.ConclusionIn this largest paediatric case collection to date, cryotherapy was safe and carried a high success rate. Cryobiopsy compares favourably to the widely used forceps biopsy and could replace it in the future. Paediatric bronchoscopists are encouraged to add cryotherapy to their armamentarium of airway interventions.
A case of giant dental calculus in a patient with centronuclear myopathy
Authors: Iwama Ryosuke , Nagai Hirokazu , Suzuki Naoki , Izumi Rumiko , Kumamoto Hiroyuki , Takahashi Tetsu 
Published: August 2022

AbstractIntroductionCentronuclear myopathy is a hereditary congenital muscle disease. It is characterized by generalized muscle hypotonia from early childhood, elongated cacial appearance, mandibular undergroth, and dental malposition. In this report, we discuss the clinical course and management of a patient with centronuclearmyopathy, who developed a giant dental calculus in the floor of the mouth and underwent surgical excision.Case ReportA 37‐year‐old Japanese man was referred to our hospital, and reported a swelling in the floor of the mouth. The patient affects centronuclear myopathy and has generalized muscle weakness. CT images showed a high‐density area in the floor of the mouth measuring 35 × 28 × 20 mm. The lesion was clinically diagnosed as giant dental calculus, and surgically removed.ConclusionWe have experienced a case of giant dental calculus in a patient with centronuclear myopathy. In dental treatment, we must consider generalized muscle weakness.
ON THE SYNTAX OF VP DISLOCATION IN MANDARIN*
Authors: Jheng Wei‐Cherng Sam 
Published: August 2022

AbstractBy drawing on data of two types of VP dislocation in Mandarin, this paper argues that these two types represent a syntactic incarnation of XP‐split constructions providing an interesting argument for the conception of information structure starting in the numeration and multiple Spell‐Out of copies regulated by the checking of strong features over the course of a syntactic derivation. Building on Fanselow and Ćavar’s (2002) distributed deletion analysis, I show that Type 1 involves two autonomous nominals that form a nominal predicate structure in a VP, and the VP is copied and internally merged to a topic position, followed by multiple Spell‐Out of the copies whose information structural features are checked. In contrast, Type 2 is derived via base‐generation. I argue that the two types are derived employing the same set of operations in the computational system without extra postulations. Issues involved in dealing with Mandarin topic constructions are addressed.
The challenging estimation of trade elasticities: Tackling the inconclusive Eurozone evidence
Authors: Keil Sascha 
Published: August 2022

AbstractThis paper sheds light on serious methodological difficulties of employing the empiric export equation in order to derive long‐run trade elasticities. The unreliable estimated price coefficient (Kaldor paradox) and the potential presence of cointegration are identified as the most relevant points. It can be shown that difficulties are in part due to methodological issues. New empirical evidence, encompassing 11 Euro area countries and the timespan 1995–2021, has been obtained from different cointegration techniques. In almost all cases, a robust long‐run relationship was detected. Price competitiveness was consistently found to be a decisive determinant of European trade flows.
Inclusion of airway pressure release ventilation in the management of respiratory failure and refractory hypercapnia in a dog
Authors: Kovak Natalie , DeRosa Sage , Fischer Christiana , Murphy Kellyann , Wolf Jacob 
Published: August 2022

AbstractObjectiveTo describe the use of airway pressure release ventilation (APRV) to relieve hypercapnia in a dog undergoing mechanical ventilation.Case SummaryA 3‐month‐old male Shar‐Pei mix presented to the emergency department with suspected noncardiogenic pulmonary edema. Due to severe hypercapnia, mechanical ventilation was initiated. The hypercapnia failed to improve with conventional pressure control mechanical ventilation, bronchodilator administration, suctioning, or endotracheal tube replacement. The dog was transitioned to APRV and maintained in this mode for 36 hours. A modified APRV protocol in which inverse inspiratory to expiratory ratios ranged from 4.3:1 to 6.0:1 was utilized, resulting in a drastic improvement in the patient's hypercapnia. The patient eventually was transitioned off the ventilator, and no respiratory abnormalities have been noted at subsequent recheck examinations.New or Unique Information ProvidedThis case documents the first use of APRV to relieve refractory hypercapnia in a dog undergoing mechanical ventilation and is one of the only recorded cases of using APRV for this purpose in the medical literature at large. APRV may be considered in cases of hypercapnia when traditional therapies fail, although caution is warranted as this mode of ventilation can also worsen hypercapnia.
Child life specialist practice and utilization across health care: a scoping review protocol
Authors: Rosenblatt Audrey , Pederson Renee , Davis-Sandfoss Tyler , Irwin Lauren , Mitsos Rebecca , Manworren Renee 
Published: August 2022

Objective:
The objective of this review is to map the available evidence regarding the scope of child life specialist practice and utilization.

Introduction:
Child life specialists provide developmentally appropriate and emotion-focused supportive interventions that aim to build coping skills, enhance resilience, and mitigate traumatic experiences during health care encounters. Evidence of the care provided by a child life specialist is spread throughout health care literature. It is an emerging field that is aligned with a heightened focus on mental health and emotional safety. Evidence for the efficacy of child life specialists continues to grow.

Inclusion criteria:
Mapping the current evidence will capture the breadth of services provided by child life specialists. This scoping review will consider all evidence that reports on services provided by child life specialists, including across all quantitative and qualitative study designs, systematic reviews, and scoping reviews. The review will also include child life specialist workforce studies, such as child life specialist utilization, geographic availability, multidisciplinary team integration, and clinician-focused research. Case studies or narrative experiences outside of a qualitative research methodology, descriptions of program implementation, educational surveys, and quality improvement projects will be excluded from the scoping review.

Methods:
JBI methodology for scoping reviews will guide the review process. Literature published from 1980 to the present will be included. Databases to be searched include PubMed, Scopus, PsycINFO, and CINAHL. The search for unpublished evidence will include Google Scholar and OpenGrey. Extracted data will be presented in tabular format with accompanying narrative summary.
Influence of Off Gas Recirculation on the Intermediate Temperature SOFC With Partial Oxidation Reformer
Authors: Li Siyuan , Zhang Zhe , Li Guoxiang , Bai Shuzhan 
Published: August 2022

Abstract
Solid oxide fuel cell (SOFC) is a clean and efficient energy utilization technology. Partial oxidation reforming (POX) can be used to simplify the SOFC system structure, but its lower hydrogen production rate deteriorates the system performance. A wise method may be combining anode off gas recirculation (AOGR) and cathode off gas recirculation (COGR) with POX. Thus, their influence on the coupled system of intermediate temperature SOFC and POX is researched in detail in this paper. Results show that the reforming process gradually changes from exothermic to endothermic as AOGR rate increases. Meanwhile, its oxygen demand declines sharply and the process can even be self-sustained without external air input at the AOGR rate of 0.5 and 0.6. The application of AOGR can improve electrical efficiency by up to 51%, but at the expense of thermal efficiency. Excessive AOGR rates will result in decreased cell voltage and insufficient energy supply to the after-burner, so it should be restricted within a reasonable range and the best recommended value is 0.5. The application of COGR has little effect on fuel line parameters, so it causes little deterioration in electrical efficiency while improving thermal efficiency. Besides, the cell voltage is also insensitive to it. The combination of AOGR and COGR can obtain better fuel economy and larger cogeneration scale simultaneously at the cost of a tiny electrical output power, while an optimal balance between three efficiencies is also achieved.
Computational Fluid–Structure Interaction Analysis of Piston Pin Multiphase Elastohydrodynamic Lubrication With Unsteady Flow Channel Variation
Authors: Narumi Yudai , Ishimoto Jun , Kanayama Daisuke , Kuribara Hiroshi , Nakano Yoshikatsu 
Published: August 2022

Abstract
This research focuses on the multiphase oil film tribology between the piston pin and the connecting rod in an internal combustion engine and establishes a new computational approach for thin-film lubrication with unsteady flow channel variation. First, the pin and the connecting rod are considered as rigid bodies, and 3D numerical analysis of the cavitating lubricating oil flow is performed when combustion load is applied to the pin. We find that dynamic pressure does not increase around the connecting rod edge and that pressure is potentially insufficient to support the load. In the second numerical analysis, the pin and the connecting rod are considered to be elastically deformable structures, and coupled 3D multiphase fluid–structure interaction simulation is performed. The boundary lubrication area is detected using a statistical Greenwood–Tripp model as unevenness of the contacted metal surface. The results show that pressure distribution spreads more widely than in the result for rigid bodies and that the film was thicker as well. Also, the pin deformed like a bow, but the deformation of the connecting rod was quite small, suggesting a potential mechanical contact at the edge of the connecting rod with the pin. By comparison with an actual operationally used piston pin, we find that the fluid–structure coupled analysis qualitatively predicted the seizure location.
Neutron Polarization Observables in $$d(\vec {\gamma },\vec {n})p$$ at Low Energies of Interest to Astrophysics
Authors: Shilpashree S. P. , Shastri Venkataramana 
Published: August 2022

A model-independent theoretical analysis of neutron polarization observables in $$d(\vec {\gamma },\vec {n})p$$ using circularly polarized photons at the range of energies of interest to Big Bang Nucleosynthesis is presented. An investigation of various spin dependent observables is carried out including the isoscalar multipole amplitudes $$M{{1}_{s}}$$ and $$E{{2}_{s}}.$$ It is suggested that the measurement of neutron polarization in the final state at near threshold energies will be very useful to assess the contribution of isoscalar amplitudes at range of energies of interest to Big Bang Nucleosynthesis.
Expression of CASC8 RNA in Human Pancreatic Cancer Cell Lines
Authors: Burenina O. Y. , Lazarevich N. L. , Kustova I. F. , Zatsepin T. S. , Rubtsova M. P. , Dontsova O. A. 
Published: August 2022

Abstract
A lot of long non-coding RNAs (lncRNAs) are expressed in human cells in a number of transcripts of different lengths and composition of exons. In case of cancer-associated lncRNAs, an actual task is to determine their specific isoforms, since each transcript can perform its own function in carcinogenesis and might have a unique expression profile in various types of tumors. For the first time, we analyzed the expression of CASC8 lncRNA in human pancreatic ductal adenocarcinoma cell lines and found an abundant isoform that was previously considered as the minor one in this type of cancer. We also revealed extremely high expression levels of all CASC8 transcripts in MIA PaCa-2 cells and, conversely, the lack of this lncRNA in PANC-1. This allows to use them as convenient models for further in vitro studies.
Biologically effective doses of 60–70Gy versus >70Gy of stereotactic body radiotherapy (SBRT) combined with chemotherapy in locally advanced pancreatic cancer: protocol of a single-centre, phase II clinical trial
Authors: Ye Yusheng , Zhu Xiaofei , Zhao Xianzhi , Jiang Lingong , Cao Yangsen , Zhang Huojun 
Published: August 2022

IntroductionThere is a paucity of studies about whether dose escalation of stereotactic body radiation therapy (SBRT) prolongs survival compared with de-escalation for patients with locally advanced pancreatic cancer (LAPC). Therefore, the aim of the study is to compare the survival benefits of biologically effective dose (BED10, α/β=10) of 60–70 Gy with those of BED10>70 Gy.Methods and analysisThis study is a single-centre, phase II trial. Patients with LAPC are randomly allocated to receive SBRT with BED10of 60–70 Gy or >70 Gy in 5–6 fractions combined with gemcitabine plus albumin-bound paclitaxel. The primary outcome is progression-free survival. The secondary outcomes are adverse events, local control and overall survival.Ethics and disseminationThe trial protocol has been approved by the Ethics committee of Shanghai Changhai Hospital. The ethics number is CHEC2020-100. Study results will be disseminated through peer-reviewed journals and released in related medical conferences.Trial registration numbersNCT04603586.
Factors Associated with the Magnitude Of acUpuncture treatment effectS (FAMOUS): a meta-epidemiological study of acupuncture randomised controlled trials
Authors: Gang Wei-Juan , Xiu Wen-Cui , Shi Lan-Jun , Zhou Qi , Jiao Rui-Min , Yang Ji-Wei , Shi Xiao-Shuang , Sun Xiao-Yue , Zeng Zhao , Witt Claudia M , Thabane Lehana , Song Ping , Yang Long-Hui , Guyatt Gordon , Zhang Zhi-Yun , Li Heng-Cong , Shi Jing-Tao , Chen An-Li , Qu Zheng-Yang , Zou Ling , Mou Dong-Xiao , Wang Xiao-Yu , Yu Qing-Quan , Chen Li-Zhen , Huang Yu-Ting , Pereira Tiago V , Chambers Jason , Ho Cameron , Bakaa Layla , Loniewski Kevin , Tong Kyle , Tong Jaryd , Dookie Jared E , Zhu Jie-wei , Hu Malini , Suk Yujin , Wu Kay , Lopes Luciane Cruz , White Julia , Buchan Tayler A , Mazzei Lauren Giustti , Alves Maíra Ramos , Moura Mariana Del Grossi , Bergamaschi Cristiane De Cássia , Meng Jing , Chan Cynthia , Sorrilha Flávia Blaseck , Jing Xiang-Hong , Zhang Yu-Qing 
Published: August 2022

ObjectiveTo identify factors and assess to what extent they impact the magnitude of the treatment effect of acupuncture therapies across therapeutic areas.Data sourceMedline, Embase, Cochrane Central Register of Controlled Trials, China National Knowledge Infrastructure, Wanfang Database, VIP Database, and China Biology Medicine disc, between 2015 and 2019.Study selectionThe inclusion criteria were trials with a total number of randomised patients larger than 100, at least one patient-important outcome and one of two sets of comparisons.Data analysisThe potential independent variables were identified by reviewing relevant literature and consulting with experts. We conducted meta-regression analyses with standardised mean difference (SMD) as effect estimate for the dependent variable. The analyses included univariable meta-regression and multivariable meta-regression using a three-level robust mixed model.Results1304 effect estimates from 584 acupuncture randomised controlled trials (RCTs) were analysed. The multivariable analyses contained 15 independent variables . In the multivariable analysis, the following produced larger treatment effects of large magnitude (>0.4): quality of life (difference of adjusted SMDs 0.51, 95% CI 0.24 to 0.77), or pain (0.48, 95% CI 0.27 to 0.69), or function (0.41, 95% CI 0.21 to 0.61) vs major events. The following produced larger treatment effects of moderate magnitude (0.2–0.4): single-centred vs multicentred RCTs (0.38, 95% CI 0.10 to 0.66); penetration acupuncture vs non-penetration types of acupuncture (0.34, 95% CI 0.15 to 0.53); non-pain symptoms vs major events (0.32, 95% CI 0.12 to 0.52). The following produced larger treatment effects of small magnitude (<0.2): high vs low frequency treatment sessions (0.19, 95% CI 0.03 to 0.35); pain vs non-pain symptoms (0.16, 95% CI 0.04 to 0.27); unreported vs reported funding (0.12, 95% CI 0 to 0.25).ConclusionPatients, clinicians and policy-makers should consider penetrating over non-penetrating acupuncture and more frequent treatment sessions when feasible and acceptable. When designing future acupuncture RCTs, trialists should consider factors that impact acupuncture treatment effects.
How has the emergence of the Omicron SARS-CoV-2 variant of concern influenced worry, perceived risk and behaviour in the UK? A series of cross-sectional surveys
Authors: Smith Louise E , Potts Henry WW , Amlôt Richard , Fear Nicola T , Michie Susan , Rubin G James 
Published: August 2022

ObjectivesTo investigate changes in beliefs and behaviours following news of the Omicron variant and changes to guidance understanding of Omicron-related guidance, and factors associated with engaging with protective behaviours.DesignSeries of cross-sectional surveys (1 November to 16 December 2021, five waves of data collection).SettingOnline.ParticipantsPeople living in England, aged 16 years or over (n=1622–1902 per wave).Primary and secondary outcome measuresLevels of worry and perceived risk, and engagement with key behaviours (out-of-home activities, risky social mixing, wearing a face covering and testing uptake).ResultsDegree of worry and perceived risk of COVID-19 (to oneself and people in the UK) fluctuated over time, increasing slightly around the time of the announcement about Omicron (p<0.001). Understanding of rules in England was varied, ranging between 10.3% and 91.9%, with people overestimating the stringency of the new rules. Rates of wearing a face covering and testing increased over time (p<0.001). Meeting up with people from another household decreased around the time of the announcement of Omicron (29 November to 1 December), but then returned to previous levels (p=0.002). Associations with protective behaviours were investigated using regression analyses. There was no evidence for significant associations between out-of-home activity and worry or perceived risk (COVID-19 generally or Omicron-specific, p≥0.004; Bonferroni adjustment p<0.002 applied). Engaging in highest risk social mixing and always wearing a face covering were associated with worry and perceived risk about COVID-19 (p≤0.001). Always wearing a face covering in shops was associated with having heard more about Omicron (p<0.001).ConclusionsAlmost 2 years into the COVID-19 outbreak, the emergence of a novel variant of concern only slightly influenced worry and perceived risk. The main protective behaviour (wearing a face covering) promoted by new guidance showed significant re-uptake, but other protective behaviours showed little or no change.