bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sharing space at the research table: exploring public and patient involvement in a methodology priority setting partnership
Authors: Burke Nikita N , Stewart Derek , Tierney Theresa , Worrall Andrew , Smith Maureen , Elliott Jim , Beecher Claire , Devane Declan , Biesty Linda 
Published: November 2022

Abstract
Background: Public and patient involvement aims to improve research quality, relevance, and appropriateness. Despite an increasing evidence base on the influence of public involvement in health research, the role of involvement in methodology research, i.e., how we plan, do, and share research, is less clear. Using a qualitative case study, we explored public involvement in a research priority-setting partnership in rapid review methodology (Priority III) to support public involvement in future methodology research.
Methods: Participant observation, documentary analysis, interviews and focus groups were used to explore the processes of Priority III and identify the views and experiences of the participants of a steering group (n=26) regarding public involvement in a methodology priority-setting partnership. We used a single intrinsic case study research design and conducted two focus groups with five public partners, one focus group with four researches; and seven 1:1 interviews with researchers/methodologists and public partners. Nine episodes of participant observation were conducted. All data were analysed using template analysis.
Results: The findings of this study present three main themes and six subthemes:
Theme 1: We all bring unique qualities to the table
Subtheme 1.1 - Coming from different perspectives towards shared-decision making;
Subtheme 1.2 - Public partners bring pragmatism and grounding in reality;
Theme 2: We need support and space at the table
Subtheme 2.1 – Define and develop support needed for meaningful involvement;
Subtheme 2.2 - Creating safe space to listen, challenge and learn;
Theme 3: We all benefit from working together
Subtheme 3.1 - Reciprocity in mutual learning and capacity building;
Subtheme 3.2 - Relationships as partners in research, with a feeling of togetherness.
Conclusions: Despite initial uncertainty due to working outside of their comfort zones, public partners contributed meaningfully to a methodology priority-setting partnership when supported to address the challenges around an abstract topic to which all brought different perspectives. Our findings provide insight into factors that facilitated public involvement in this research context. Communication and trust underpin the findings. We also provide examples of practical actions and considerations for future research and research teams.
Sequencing strategies with ramucirumab and docetaxel following prior treatments for advanced non-small cell lung cancer: a multicenter retrospective cohort study
Authors: Tanizaki Satoshi , Matsumoto Kinnosuke , Tamiya Akihiro , Taniguchi Yoshihiko , Matsuda Yoshinobu , Uchida Junji , Ueno Kiyonobu , Kawachi Hayato , Tamiya Motohiro , Yanase Takafumi , Suzuki Hidekazu , Okishio Kyoichi 
Published: November 2022

Abstract
Objectives
Ramucirumab (RAM) and docetaxel (DOC) are commonly used after first-line therapy for advanced non-small-cell lung cancer (NSCLC). Therefore, we aimed to elucidate sequencing strategies of RAM and DOC following prior treatments, including immune checkpoint inhibitor (ICI), cytotoxic agent (CTx) alone, bevacizumab (BEV), and tyrosine kinase inhibitor (TKI).
Methods
We recruited patients with NSCLC who received RAM and DOC and compared the groups with and without prior ICI, CTx alone, BEV, and TKI, respectively. By tumor response to such treatments, the patients were further classified into “complete response (CR) + partial response (PR),” “stable disease,” and “progressive disease” groups, respectively. We compared RAM and DOC efficacy among these groups.
Results
In total, 237 patients were registered. In the group with prior ICI, the objective response rate and disease control rate were significantly higher than those without prior ICI (p = 0.012 and 0.028, respectively), and the median progression-free survival (PFS) was also significantly longer (p = 0.027). There were no significant differences in PFS between the groups with and without CTx alone, BEV, and TKI. Multivariate analysis revealed that prior ICI was an independent factor associated with better PFS. Furthermore, the prior ICI group with CR + PR significantly prolonged PFS compared to the group without prior ICI (p = 0.013).
Conclusion
RAM and DOC may be preferably administered after ICI, rather than after CTx alone, BEV, or TKI, and furthermore, enhanced if the prior ICI has a favorable tumor response.
How environmental factors condition natural regeneration in the altitudinal gradient of a montane rainforest
Authors: Duarte Victor Braga Rodrigues , Abreu Vítor Souza , Dias Henrique Machado , Kunz Sustanis Horn , Berg Eduardo van den 
Published: November 2022

Abstract

The variation of abiotic factors, and the plant species response to it, influence the regeneration capacity and, consequently, the structure of the forest community. The aim of this study is to describe the structure of the regenerating stratum and investigate its relationship with environmental and spatial variables along an altitudinal gradient. This study was carried out in the Santa Marta valley, state of Espírito Santo, Brazil. Data on height and diameter at soil height of regenerating individuals and environmental variables were collected in seven altitudinal quotas; and spatial variables (Moran’s Eigenvector Maps) were created based on geographic coordinates. Phytosociological parameters were calculated by species and the floristic similarity between the altitudinal quota were determined, as well as the species that characterize each group. Redundancy Analysis (RDA) was performed, and generalized linear models were adjusted to verify the influence of environmental and spatial factors on regenerating vegetation. The speciePalicourea sessilispresented the highest Importance Value. The formation of two floristic groups was verified, with 11 species indicative of the higher quota group (1,420 to 1,550 m) and only one of the second group (1,112 to 1,391 m). The first two axes of the RDA explained 51.02% of the variation in the floristic composition. The natural regeneration demonstrated environmental preferences, being influenced by luminosity, abundance in adult components, contents of calcium and sodium, plant litter accumulation, altitude, and spatial structure of the environment. The altitude did not seem to influence a pattern in abundance or richness of regenerating species.
Pulsatile paraarterial flow by peristalsis, pressure and directional resistance
Authors: Sharp M. Keith 
Published: November 2022

Abstract
The mechanism driving flow through the glymphatic system is unclear. The pulsatile flow measured in the space surrounding the middle cerebral artery (MCA) suggests that peristalsis created by intravascular blood pressure pulses is a candidate. However, peristalsis is ineffective in driving significant mean flow when the amplitude of channel wall motion is small, as has been observed in the MCA paraarterial space. In this paper, peristalsis in combination with two additional mechanisms, a longitudinal pressure gradient and directional flow resistance, is evaluated to match the measured MCA paraarterial flow. Two analytical models are used that simplify the paraarterial branched network to a long continuous channel with a traveling wave in order to maximize the potential effect of peristalsis on the mean flow. For these models, the measured arterial wall motion is too large to cause the measured oscillatory velocity, indicating that the glial wall must also move. At a combined motion matching the measured oscillatory velocity, peristalsis is incapable of driving enough mean flow. Directional flow resistance elements augment the mean flow, but not enough to provide a match. With a steady longitudinal pressure gradient, both oscillatory and mean flows can be matched to the measurements.
A Novel Burst Event Detection Model Based on Cross Social Media Influence
Authors: Ban Aiying , Zhang Zhiyong , Gao Dongjun , Zhou Ying , Gupta Brij B. 
Published: November 2022

Abstract
With the frequent occurrence of public emergencies around the world today, how to effectively use big data and artificial intelligence technologies to accurately and efficiently detect and identify burst events of the Internet has become a hot issue. These existing burst event detection methods lack of comprehensively considering multi-data source of social media and their influences, which leads to a lower accuracy. This paper proposes a novel burst event detection model based on cross social media influence and unsupervised clustering. In this article, we, explain the basic framework of burst event detection, along with characteristics of social media influence, and the word frequency features and growth rate features. In our proposed approach, according to the time information in the data stream, social media network data were sliced and the burst word features in each time window were calculated. Then, the three burst features were fused to compute the burst degree of words; after that the words larger than the threshold were selected to form the burst word set. Finally, the agglomerative hierarchical clustering method is introduced to cluster the burst word set and extracts the burst event from it. The results of the experiment on a real-world social media dataset show that the detection method has significantly improved in Precision and F1-score value compared with the latest four burst event detection methods and prove the effectiveness of the proposed method.
sexual function and its associated factors in Iranians with and without a recent history of COVID-19 infection
Authors: Haghparast Zeinab , Taghizadeh Ziba , Bagheri Azam 
Published: November 2022

Abstract

This study was designed to investigate the sexual function and its associated factors in Iranian women and men with and without a recent history of contracting COVID-19. This cross-sectional study was conducted with 384 individuals from August 1 to December 25, 2021, in Iran. The respondents were asked to fill out the International Index of Erectile Function (IIEF) questionnaire, the Female Sexual Function Index (FSFI) questionnaire, the Beck Anxiety Inventory (BAI), the Beck Depression Inventory (BDI-II), and Haj-Yahia’s questionnaire of violence against women. The results showed that mean FSFI score of female respondents was 20.39 ± 4.15. Women with a recent history of COVID-19 infection had significantly lower scores in the orgasm (P = 0.012) and satisfaction (P = 0.030) dimensions of FSFI. The mean IIEF score of male respondents was 17.79 ± 4.31. There was a significant difference between groups with and without a recent history of COVID-19 in terms of mean IIEF score and also mean scores of each dimension of IIEF (p = 0.004). Multivariate regression showed that women’s sexual function was associated with age and BDI-II score, whereas men’s sexual function was associated with the history of recent COVID-19 infection and the education level. In addition, the results suggest an increase in the prevalence of sexual dysfunction during the COVID-19 pandemic in both women and men. These results can help the country’s health policymakers to devise appropriate measures for mitigating the adverse impacts of the COVID-19 pandemic on the well-being of communities, families, and individuals.
Proving Collatz Conjecture by finding cycles and diverging seeds
Authors: Ali Morad 
Published: November 2022

Abstract
The Collatz conjecture can be formulated in this question: Do we guarantee reaching one after applying function f (Hereinafter called Collatz function) multiple times? f(x) = (3x+1, x|2) ∨ (x|2, x ∤ 2) In this paper, we discuss an approach to analyze Collatz conjecture nature for all qx + 1, q ∈ {1,3,5,7,..}. this approach builds a method to know the number of potential cycles for q x + 1, q ∈ {1,3,5,7,..}, x < Mx, Mx ∈ ℂ. Multiple non-trivial cycles (numbers that form a cycle and does not reach one) were previously found where q ∈ {5, 181}. This paper will introduce equations that find non-trivial cycles, and therefore proving or disproving Collatz conjecture for any q.
Messaging Strategies of Ukraine and Russia on Telegram during the 2022 Russian invasion of Ukraine
Authors: Ghasiya Piyush , Sasahara Kazutoshi 
Published: November 2022

Abstract

The popularity of the instant messaging app Telegram in Ukraine and Russia was strong even before the still-ongoing Russian invasion of Ukraine. However, since 24 February 2022 (when the Russian invasion began), it has seen huge increases in subscribers and even become the primary communication and news source in Ukraine. In this exploratory research, we analyzed Telegram channels from both Ukraine (@UkraineNow — the official channel of the Ukrainian government, and @V_Zelenskiy_official — the official channel of Volodymyr Zelenskyy) and Russia (@rt_russian — the official channel of the news network RT) to discern the content of posts during this invasion. Our analysis of 37,172 posts in total showed that while @UkraineNow is particularly being used to communicate invasion-related news, @rt_russian is working as merely an extension of RT, which is part of the pro-Kremlin propaganda and disinformation ecosystem. However, Zelenskyy has opted for a completely different approach: he has used his Telegram channel to encourage Ukrainians and garner support from the world. The present conflict is at a critical juncture, and our timely research seeks to determine how both countries’ governments are utilizing Telegram as a weapon in the information war and what impact this has on ground.
Hepatoprotective effect of Pinostrobin against Thioacetamide-induced liver cirrhosis in rat
Authors: shareef Suhayla Hamad , Al-Medhtiy Morteta H. , Jabbar Ahmed Aj. , Aziz Peshawa Yunis , Abdulla Mahmood A. 
Published: November 2022

Abstract

Pinostrobin was used in traditional medication for management of numerous syndromes. In the current study, histology, immunohistochemistry, and hepatoprotection effects of Pinostrobin were assessed against thioacetamide (TAA) hepatotoxicity in rats. Thirty rats were arbitrarily separated into five groups. Group 1 was intraperitoneally (i.p) injected with distilled water 3 times/week and fed (po) daily with 10% Tween 20 for 2 months. Group 2–5 were i.p. injected with 200 mg/kg TAA thrice weekly for 8 weeks and fed with 10% Tween 20, 50 mg/kg silymarin, 30 and 60 mg/kg of Pinostrobin daily for 8 weeks, respectively. Experimental groups fed groups showed that Pinostrobin significant reduction in liver index and hepatocyte proliferation with much lesser cell injury. These groups were significantly down-regulated the PCNA and α-SMA. The liver homogenate exhibited increased antioxidant enzymes (SOD and CAT) activities accompanied with decline in malondialdehyde (MDA) level. The serum level of bilirubin, total protein, albumin and liver enzymes (ALP, ALT, and AST) were restored to normal and were comparable to that normal control and silymarin with TAA treated groups. The hepatotoxic group showed a significant rise in serum liver biochemical markers together with a considerable decrease in protein and albumin level compared to the normal group. The hepatotoxic group displayed decreased catalase and superoxide dismutase activities while increased lipid peroxidation. Pinostrobin decreased level of TNF-a, IL-6 and increased the level of IL-10. Acute toxicity with a higher dose of 500 mg/kg Pinostrobin did not manifest any toxicological signs in rats. Macroscopy of hepatotoxic liver exhibited irregular, rough surface with micro and macro nodule. Histopathology stained by Hematoxylin and Eosin, and Masson Trichrome showed there was inflammation and infiltration of lymphocytes, focal necrosis, fibrosis, and bile duct propagation. Pinostrobin fed group had expressively reduced TAA toxicity in gross and histology as designated by fewer disturbances of hepatic tissue, slight fibrosis, and low-grade cells infiltration. Immunohistochemical staining designated that pinostrobin significantly down-regulated the expression of proliferation cellular nucleus antigen (PCNA) and alpha-smooth muscle actin (α-SMA) in the liver. Thus, the findings of this study presented that the hepatoprotective effect of this plant may be due to a reduction in toxicity, inhibition of hepatocytes proliferation, down-regulation of PCNA and α-SMA, decreased enzyme markersand increased protein and albumin increased endogenous enzymes and reduced lipid peroxidation level.
The largest fully protected marine area in North America does not harm industrial fishing
Authors: Favoretto Fabio , López-Sagastegui Catalina , Sala Enric , Aburto-Oropeza Octavio 
Published: November 2022

Abstract
Marine protected areas (MPAs) that ban fishing restore marine life within their boundaries and can also replenish nearby fisheries. However, some argue that after large MPAs are established, fishing effort is displaced to unprotected areas and economic loss is incurred by the fishing industry. We tested these assumptions by assessing the behavior and productivity of the Mexican industrial fishing fleet before and after the implementation of the largest fully protected MPA in North America (the 147,000 km2 Revillagigedo National Park). We found no significant decrease in catches and no causal link between the variation of the spatial footprint of the industrial fleet and the implementation of the MPA. Our findings add to growing evidence that well-designed MPAs benefit marine ecosystems and, in the long term, can also benefit the fisheries they support.
A Phenome-Wide Association Study (Phewas) Of Late Onset Alzheimer Disease Genetic Risk in Children of European Ancestry at Middle Childhood: Results From the ABCD Study
Authors: Gorelik Aaron , Paul Sarah , Karcher Nicole , Johnson Emma , Nagella Isha , Blaydon Lauren , Modi Hailey , Hansen Isabella , Colbert Sarah , Baranger David , Norton Sara , Spears Isaiah , Gordon Brian , Zhang Wei , Hill Patrick , Oltmanns Thomas , Bjisterbosch Janine , Agrawal Arpana , Hatoum Alexander , Bogdan Ryan 
Published: November 2022

Abstract
Genetic risk for Late Onset Alzheimer disease (AD) has been associated with lower cognition and smaller hippocampal volume in healthy young adults. However, it remains unclear whether these and other associations are present during childhood. Using data from 5,556 genomically-confirmed European ancestry youth who completed the baseline session of the ongoing the Adolescent Brain Cognitive Development StudySM (ABCD Study®), our phenome-wide association study estimating associations between indices of genetic risk for late-onset AD (n = 4; AD polygenic risk scores (PRS), APOE rs429358 genotype, AD PRS with the APOE region removed (ADPRS−APOE), and an interaction between ADPRS−APOE and APOE genotype) and 1,687 psychosocial, behavioral, and neural phenotypes revealed no significant associations after correction for multiple testing (all ps > 0.0002; all pfdr>0.07). These data suggest that AD genetic risk may not phenotypically manifest during middle-childhood or that effects are smaller than this sample is powered to detect.
Effect of vacuum level on udder aspect and milking in the Sicilo-Sarde ewes
Authors: Mohamed Chniter , Taboubi Iheb , Dhaoui Amel , Darej Cyrine , Naceur M’Hamdi , Moujahed Nizar 
Published: November 2022

Abstract
The aim of this study was thus to investigate the effect vacuum level on udder traits, milking time, milk yield and components in Tunisian Sicilo-Srade ewes. Trial was carried out at the UCPA farm of Gnadil-Béja (Tunisia) among 3 periods of late lactation where 3 vacuum levels (40, 50 and 60 kPa) were applied for each one. Udder traits were measured before each milking, and milking time and milk amount were recorded. Milk total solids (TS), fat, solids not fat (SNF), protein, lactose, milk urea nitrogen (MUN) and somatic cell counts (SCC) were determined. Significant effects of lactation day were observed on udder traits with the exception of teats length. Machine milking time and milk yield were the highest at the beginning of the experiment. Excepting somatic cell counts and milk urea nitrogen, the highest values of milk components were observed at the intermediate period of experiment. Significant effects of vacuum level on machine milking time and milk yield were observed, where values are the highest with the low (40 kPa) and the intermediate (50 kPa) vacuum levels, respectively. Similarly, milk solids not fat content was higher in the groups of 40 and 50 kPa than that of 60 kPa. Contrarily to protein content, milk fat obtained with 50 kPa was higher than those of 40 and 60 kPa. In conclusion, the use of a medium vacuum level of 50 kPa seems to be the suitable choice at late lactation in the dairy Sicilo-Sarde ewe with more efficient of milking performances and any detrimental effects on udder health.
Relationships Between Processes and Profit: A Work-Based Assessment of Processes Within South East Queensland-Based Financial Planning Firms
Authors: Neilson Ben 
Published: November 2022

AbstractThis research explores the relationships between process and profit. It leverages data collected from 134 financial planning firms in South East Queensland as a sample size. It introduces a complete process framework designed using Kotter’s change framework and measures the effects on relationships. The results suggest that firms’ process is positively associated with profit, and that both process and profit are further correlated to decreasing effects of firms’ agency theory. Process development often mediates the relationships between process and profit when introduced with a specific framework design as a result.
An online serious game improves aspects of clinical reasoning skills in dietetic students
Authors: Wright Hattie H. , Tweedie Judith , Ashford Theresa 
Published: November 2022

Abstract

Virtual learning environments, including computer-assisted instruction and game-based learning, have become increasingly popular as educational tools. The present study sought to evaluate the potential of an online serious game to improve the clinical reasoning ability of pre-placement dietetic students during nutrition care planning (NCP). A pre-post-test study design investigated lower- and higher-level clinical reasoning skills in 43 pre-placement dietetics students, as well as perceptions on learning experiences, self-confidence, and views of NCP. Students’ ability to discriminate information, prioritise, and develop an appropriate nutrition intervention plan improved. Serious online games have potential to improve clinical reasoning skills in NCP.