bluuebunny/crossref_metadata_2025_split huggingface dataset:
Deficiency of Endothelial
Piezo2
Impairs Pulmonary Vascular Angiogenesis and Predisposes Pulmonary Hypertension
Authors: Wei Feng , Lin Ziying , Lu Wenju , Luo Haiyun , Feng Huazhuo , Liu Shiyun , Zhang Chenting , Zheng Yulin , Jiyuan Chen , Mo Shaocong , Wang Chen , Zhang Zizhou , Feng Wei , Zhu Junqi , Yang Qifeng , Du Min , Kong Weiguo , Liu Aofeng , Lai Jiaxuan , Li Xiang , Wu Xuefen , Lai Ning , Chen Yuqin , Yang Kai , Wang Jian 
Published: January 2025

BACKGROUND:
Mechanosensitive Piezo1 channel plays a key role in pulmonary hypertension (PH). However, the role of Piezo2 in PH remains unclear.

METHODS:

Endothelial cell (EC)–specific
Piezo2
knockout (
Piezo2
flox/flox
, Tek-Cre
+
;

Piezo2
EC−/−

) rats and primarily cultured pulmonary microvascular ECs were used to determine the role of Piezo2 in PH.

RESULTS:

Data analysis of publicly accessible single-cell RNA-sequencing data sets uncovered significant downregulation of Piezo2 in lung ECs from patients with idiopathic pulmonary arterial hypertension, which was verified in the lungs/ECs from PH rat models induced by hypoxia or monocrotaline. Comparing to wild-type rats,
Piezo2

EC

−/−

rats exhibited exacerbated PH in both hypoxia-induced PH and monocrotaline-induced PH, characterized by the worsened hemodynamical and histological changes.
Piezo2

EC

−/−

rats showed dramatic loss of pulmonary microvessels, in association with the decreased intracellular free calcium concentration ([Ca
2+
]
i
) and downregulation of VEGFR2 (vascular endothelial growth factor receptor 2) and phosphorylated SRF (serum response factor) in pulmonary microvascular ECs. Knockout of
Piezo2
or treatment with a calcium chelator, EDTA, impaired the ability of tube formation and migration in pulmonary microvascular ECs, which was restored by supplementation of extra calcium. A safflower oil diet rich in linoleic acid, which can enhance the stability and function of Piezo2, effectively alleviated PH development in a hypoxia-induced PH rat model.

CONCLUSIONS:

This study demonstrates that EC-specific knockout of
Piezo2
exacerbates PH pathogenesis, at least partially, through the suppression of [Ca
2+
]
i
/phosphorylated SRF/VEGFR2 signaling axis in pulmonary vascular ECs. Targeted activation of Piezo2 could be a novel effective strategy for the treatment of PH.
Uneven Shifts: The Geography of Occupational Change in France, Italy, Spain and the United Kingdom 1992–2018
Authors: Morris Katy , Oesch Daniel 
Published: January 2025

Abstract
Amid renewed interest in geographical inequalities in life chances and an ongoing debate about occupational upgrading versus polarisation, we investigate how the occupational structure changed across NUTS-2 regions in France, Italy, Spain and the UK between 1992 and 2018. Against the expectation that national upgrading trends may mask a diversity of regional upgrading, downgrading and polarisation experiences, EU Labour Force Survey data show clear and unambiguous upgrading. In every region, employment in high quality jobs grew while employment in low quality jobs shrank. These shifts were often large in magnitude: the proportion of employment in high quality jobs increased by more than 10 percentage points in two thirds of the regions studied. However, there was considerable heterogeneity in the rate and type of occupational upgrading. Strong upgrading and employment growth in the economic capital regions of Île-de-France (Paris), Lombardy, Madrid and London contrasted with weaker upgrading and sluggish (or even negative) employment growth in regions like Lorraine, Sicily, Extremadura and the West Midlands. That these and many regions have yet to achieve the same proportion of high quality jobs that the economic capitals possessed in 1992 highlights the greater relative difficulty of ascending to the top of the occupational structure in some places than others.
‘Escape’ from Home? The Moderating Role of Sexual Orientation on the Association Between Social Origin and Educational Attainment
Authors: Kasprowski David , Boertien Diederik 
Published: January 2025

Abstract
Previous research has documented that sexual orientation relates to educational attainment, and that it might do so differently for men and women. In this paper, we investigate to what extent sexual orientation moderates the relationship between social origin and educational attainment and whether the educational premium among LGB people might be concentrated among individuals from lower socioeconomic backgrounds. We propose, elaborate, and provide a theoretical underpinning for the ‘Queer Habitus’ hypothesis which states that having an LGB identity can lead to weaker family-of-origin ties and disrupt people's class habitus. These factors can lead LGB people from lower socioeconomic backgrounds to pursue higher levels of education as compared to their heterosexual counterparts. Empirically, the paper takes advantage of the oversampling of LGB individuals in the 2019 wave of the nationally representative probability-based German Socio-Economic Panel study (SOEP; N = 15,746; LGB = 589). The findings challenge the idea that educational premiums are limited to gay men by showing that both LGB men and LGB women have higher educational attainment than their straight counterparts in Germany. Further, this educational ‘advantage’ is moderated by social origin. The higher education of LGB people is concentrated among those with disadvantaged social origin compared to straight individuals from similar social backgrounds. Overall, this lends support to the ‘Queer Habitus’ hypothesis which argues that the disruption of the heterosexual habitus by an LGB identity causes a weaker association of the social origin on educational attainment.
A Preliminary Survey of Rock Art and Early Powers in the Lower Nile Valley during the Late 4th Millennium bc
Authors: Vanhulle Dorian 
Published: January 2025

Abstract
This paper is investigating the use of rock art by local/regional powers in the Lower Nile Valley in the late 4th millennium bc. It situates the rock art record in its historical and archaeological settings and proposes methodological options (which are, in some cases, still theoretical) to elucidate it further in its social context. Two research questions are addressed: the first one discusses the existence of rock art commissioned by authorities and the criteria that could help identify them. The second deals with the ways in which rock art may express political power. The iconographic and technical aspects of rock art are discussed. This preliminary survey suggests that rock art specialists appeared at the end of the Predynastic period and that rock art may have been a strategic element in the competition between the polities that were rising in the Lower Nile Valley at that time.
Impacts of continuous cropping on soil fertility, microbial communities, and crop growth under different tobacco varieties in a field study
Authors: Xia Hao , Jiang Chaoqiang , Riaz Muhammad , Yu Fei , Dong Qing , Yan Yifeng , Zu Chaolong , Zhou Chuyue , Wang Jitao , Shen Jia 
Published: January 2025

AbstractContinuous cropping obstacles are significant factors that limit the yield and quality of tobacco. Thus, the selection and breeding of varieties is a crucial strategy for mitigating these challenges. However, the effects and mechanisms by which different tobacco varieties influence the structural composition of soil microbial remain unclear. To address this, we conducted a field experiment involving five tobacco varieties (K326, K394, XL, Y87, and Y97) and two types of soil (continuous cropping obstacle soil and normal soil). We examined microbial responses to different tobacco varieties in each soil type. Our results revealed that soil available nutrients and organic matter were decreased in obstacle soil compared to normal soil. The fresh biomass decreased by 18.05–27.92% in obstacle soil (except K394 and Y97). The microbial community composition in the rhizosphere soil remained consistent in various tobacco varieties in obstacle soil. The connections between soil fertility nutrients and microbial communities were reduced in obstacle soil compared to normal soil. The alteration of bacterial community composition was a stochastic process, whereas the modification of fungal community composition was a deterministic process in obstacle soil. Furthermore, the abundance of differential fungi (Zoopagomycota) was notably higher in obstacle soil. Overall, our results revealed that the disturbance of microbial communities and soil degradation in the obstacle soil are primary factors contributing to reduced crop yields. Therefore, it is an economical strategy for overcoming continuous cropping obstacles by utilizing rhizosphere microecology through multi-variety planting.
Navigating complex arterial reconstruction in living donor liver transplantation: the role of the splenic artery as a viable conduit
Authors: Hamed Hosam , Elshobary Mohamed , Salah Tarek , Sultan Ahmad M. , Abou El-Magd El-sayed , Elsabbagh Ahmed M. , Shehta Ahmed , Abdulrazek Mohamed , Elsarraf Waleed , Elmorshedi Mohamed A. , Abdelkhalek Mostafa , Shiha Usama , El Razek Hassan Magdy Abd , Wahab Mohamed Abdel 
Published: January 2025

Abstract
Background
In living donor liver transplantation (LDLT), maintaining hepatic arterial flow is critical for graft survival. Alternative methods are required when the recipient’s hepatic artery is unsuitable due to extensive dissection or inadequate flow. This study evaluates the efficacy and safety of splenic artery transposition (SAT) for hepatic arterial reconstruction in LDLT.

Methods
This retrospective cohort study included 10 LDLT patients with hepatic arterial reconstruction by SAT to assess operative parameters, postoperative complications, mortality, and patency rate.

Results
The splenic artery was used because of arterial dissection (70%) or inadequate arterial blood flow. Operative time ranged from 640 to 1020 min, and no splenic infarction was observed. Post-operative complications were as follows; biliary leakage (10%), pancreatitis (10%), intraabdominal hemorrhage (10%), and arterial thrombosis (10%). Mortality in this cohort was 30%, one of them was due to thrombosis of the conduit and the other two died from sepsis-related complications. With a median follow-up of 43 months, this technique was associated with a 70% survival rate.

Conclusion
The splenic artery is a viable conduit for hepatic arterial reconstruction in LDLT, demonstrating an acceptable safety profile and complication rates. This approach is recommended in cases where the recipient’s hepatic artery is significantly compromised.
Trueness of tooth modified scan bodies as a novel technique for edentulous full arch implant supported dental prosthesis: an in vivo prospective comparative study
Authors: Eldabe Abdelrahman K. , Adel-Khattab Doaa , Botros Kirollos H. 
Published: January 2025

Abstract
Objective
This study aimed to evaluate the clinical performance (degree of trueness) of a novel scan body “tooth-modified Scan body” (TMSB)& conventional scan body (CSB) in implant-supported full arch screw retained cases.

Methods
Seven edentulous arches (two maxillae, five mandibles) in 6 patients were rehabilitated with monolithic zirconia screw-retained implant prostheses supported by 4 (n = 1) and 5 implants (n = 6) for a total amount of 34 implants. Implant locations were scanned by intra-oral scanner (IOS) using two types of scan bodies, conventional scan bodies (CSB) in group (1) and tooth-modified scan bodies (TMSB) in group (2). 68 implant positions (representing the total sample size) were captured and compared to the relative reference scans regarding angular and Euclidian deviation (ΔEUC).

Results
The ΔEUC deviation Of TMSB group had lower values (M = 61.46, SD = 42.12) than that Of CSB group (M = 97.97, SD = 56.69). This difference was statistically significant (p = .005), 95% Confidence interval. The angular deviation of TMSC group had lower values (M = 0.85, SD = 0.69) than that Of CSB group (M = 1.3, SD = 1.06) which was statistically significant (p = .033), 95% Confidence interval. There was a correlation between the type of Jaw and both angular and ΔEUC deviation of both groups, which was statistically significant.

Conclusion
A tooth-modified scan body (TMSB) may improve the ease and trueness of full-arch implant scanning, even in challenging mandibular arches.

Clinical trial registry date
Retrospectively registered in 20/ 12/ 2023.

Clinical trial registry number
NCT06177782.
Implementation processes and capacity-building needs in Ontario maternal-newborn care hospital settings: a cross-sectional survey
Authors: Reszel Jessica , Daub Olivia , Dunn Sandra I. , Cassidy Christine E. , Hafizi Kaamel , Lightfoot Marnie , Pervez Dahlia , Quosdorf Ashley , Wood Allison , Graham Ian D. 
Published: January 2025

Abstract
Background
Maternal-newborn care does not always align with the best available evidence. Applying implementation science to change initiatives can help move evidence-informed practices into clinical settings. However, it remains unknown to what extent current implementation practices in maternal-newborn care align with recommendations from implementation science, and how confident nurses, other health professionals, and leaders are completing steps in the implementation process. We aimed to understand Ontario maternal-newborn teams’ (1) approaches to implementing practice changes and the extent to which their implementation processes aligned with an implementation science planned-action framework; and (2) perceptions of importance and confidence completing implementation activities.

Methods
We conducted a cross-sectional survey between September–November 2023. Using purposive sampling, we invited Ontario maternal-newborn nurses, other healthcare professionals, and leaders who had experience participating in or leading implementation projects to complete an online questionnaire. The questionnaire was informed by an implementation science framework, which includes three core phases (identify issue; build solutions; implement, evaluate, sustain). The questions probed respondents’ perceptions of frequency of completion, importance, and confidence for each of the 28 implementation activities. We used descriptive statistics for the closed-ended questions and grouped the written responses into categories.

Results
We received 73 responses from 57 Ontario maternal-newborn hospitals, the majority being nurses in point-of-care and leadership roles. Nearly all respondents agreed that each of the 28 implementation activities were important. Respondents reported always completing a median of 8 out of 28 activities, with the number of activities completed declining from phase 1 through to 3. Most respondents indicated they were somewhat confident completing the implementation activities and agreed their teams would benefit from increasing their knowledge and skills to use an evidence-informed approach to implementing practice changes.

Conclusions
Despite viewing implementation activities as important, many teams are not consistently doing them and lack confidence, particularly in later phases of the implementation process. These findings inform where further capacity-building and supports may be needed to enable maternal-newborn nurses, other healthcare professionals, and leaders to apply implementation science to their change initiatives.
The development of a decision support tool in the prehospital setting for acute chest pain – a study protocol for an observational study (BRIAN2)
Authors: Lökholm Elin , Magnusson Carl , Herlitz Johan , Ravn-Fischer Annica , Hammarsten Ola , Johansson Magnus , Hallin Kristoffer , Wibring Kristoffer 
Published: January 2025

Abstract
Introduction
Chest pain is one of the most common reasons for contacting the emergency medical services (EMS). It is difficult for EMS personnel to distinguish between patients suffering from a high-risk condition in need of prompt hospital care and patients suitable for non-conveyance. A vast majority of patients with chest pain are therefore transported to the emergency department (ED) for further investigation even if hospital care is not necessary. Improved prehospital assessment and risk stratification, thus accurately and safely identifying patients suitable for non-conveyance, could prevent unnecessary transport to the ED. This would reduce ED crowding and overburdening sparse EMS resources. It would thus also probably reduce healthcare costs. Little is known about the prehospital use of the 5th generation, i.e. high-sensitivity troponin analyses. The aim of this project is to develop an EMS decision support tool using high-sensitivity troponin I for risk assessment of chest pain patients.

Methods and analysis
This is a prospective, multicentre, cohort study including adult unselected EMS patients with chest pain. Data is being collected from 20 May 2023 to 31 December 2025, aiming to include at least 2,000 patients. High-sensitivity troponin I is being analysed bedside using Siemens Healthineers Atellica VTLi. In addition to prehospital troponin I, data is being collected on patient medical history, onset, vital signs, symptoms, ECG and diagnosis at hospital discharge. Several statistical analyses (random forest, logistic regression, gradient boosting) will be conducted to identify the best model for identifying patients with low-risk conditions suitable for non-conveyance.

Ethics and dissemination
The study has been approved by the Swedish Ethical Review Authority (Dnr 2022-01066-01 and 2022-06846-02). Patients are being informed about the study both orally and in writing. The results of the study will be published in a peer-reviewed journal and will be presented at national and/or international conferences.

Registration details
The study is registered at ClinicalTrials.gov (NCT05767619).
Land cover classification for Siberia leveraging diverse global land cover datasets
Authors: Beak Munseon , Ichii Kazuhito , Yamamoto Yuhei , Wang Ruci , Zhang Beichen , Sharma Ram C. , Hiyama Tetsuya 
Published: January 2025

AbstractUnderstanding the land cover is crucial to comprehending the functioning of the Earth’s system. The land cover of Siberia is characterized by uncertainty because it is wide-ranging and comprises various classification types. However, comparisons among land cover products reveal substantial discrepancies and uncertainties. Therefore, a reliable land cover product for Siberia is necessary. In this study, we generated new land cover data for Siberia using random forest (RF) classifiers with global land cover datasets. To assess their accuracy and characteristics, we individually validated global land cover products in Siberia using multi-source sample datasets. We trained the RF classifiers with multiple land cover products to produce a more precise land cover product for Siberia. The validations showed that: (a) the generated new land cover data achieved the highest overall accuracy (85.04%) and kappa coefficient (82.62%); (b) the classifications of mixed forest (user accuracy: 97.85%) and grasses (user accuracy: 94.85%) demonstrated improvements, showing higher performance compared to most other types; and (c) by comparing the distribution of land cover across climate zones, we discovered that temperature is a critical factor throughout Siberia. However, in warm summer climates, precipitation plays a critical role in vegetation distribution. The more accurate and detailed land cover created in this study enhances the reliability of analyses in Siberia and fosters a deeper understanding of the impact of the carbon cycle.
Reconstruction of bottom water ventilation changes in the West Philippine Sea during the last glacial-interglacial period
Authors: Hsiung Wei-Cheng , Chang Yuan-Pin , Mii Horng-Sheng , Ikehara Ken , Kanamatsu Toshiya , Lin Hui-Ling 
Published: January 2025

AbstractGlobal deep-water circulation plays a crucial role in regulating long-term carbon storage in both the ocean and atmosphere. During the last glacial period, it is reported that this circulation slowed down, causing glacial intermediate water to descend to depths of 2,000 m in the Pacific. This process is thought to be a key mechanism in restricting global deep-water circulation and reducing atmospheric carbon dioxide concentrations during glacial periods. Conversely, the emergence of a potential deep-water formation zone in the northwestern Pacific during deglaciation adds complexity to these circulation patterns. Addressing the scarcity of sedimentary records in the subtropical western Pacific for paleoceanographic reconstruction, sediment core YK15-01 PC13 (23.5°N, 124.24°E; southeast of Ishigaki Island at a depth of 2,520 m) used in this study, collected in 2015. By analyzing coexisting planktonic and benthic foraminifera, we have reconstructed radiocarbon ventilation ages in this region since the last glacial maximum. Our findings, including ventilation age records compiled from the Atlantic and Pacific Oceans, reveal opposing deep-water circulation patterns from the last glacial to the interglacial period, including during the Heinrich Event 1 (HE1) and Younger Dryas (YD). This supports the theory of a seesaw-like oscillation in ocean circulation. Furthermore, the improved ventilation observed during HE1 and YD suggests a contribution from deep water formed in the high-latitude Pacific, influenced by cooler climate conditions. This glacial North Pacific deep water, likely confined to the northwestern Pacific, has left its mark in the subtropical western Pacific records. This research enhances our understanding of deep-water circulation interactions between the Atlantic and Pacific and contributes new insights into the role of northern Pacific deep water in influencing atmospheric carbon dioxide variations during the last deglaciation.
Analysing the financial innovation-based characteristics of stock market efficiency using fuzzy decision-making technique
Authors: Rahadian Dadan , Firli Anisah , Dinçer Hasan , Yüksel Serhat , Mikhaylov Alexey 
Published: January 2025

AbstractNecessary actions should be taken to ensure stock market efficiency; thus, financial innovation-based criteria that affect stock market efficiency should be improved. However, simultaneously improving all criteria is difficult; therefore, performing priority analysis is important for carrying out this process effectively and efficiently. Accordingly, this study aims to evaluate the financial innovation-based characteristics of stock market efficiency. This study’s main research question within this framework is identifying which factors should be prioritized to improve the stock market. In this scope, we created a novel fuzzy decision-making model consisting of two stages. First, selected criteria for the financial innovation-based characteristics of stock market efficiency are weighted. In this process, quantum spherical fuzzy sets based on DEMATEL are considered. In the second stage, selected economies are ranked using the technique for order of preference by similarity to ideal solution (TOPSIS) approach. This study’s main contribution is that the DEMATEL technique in calculating criterion weights in the decision-making analysis process provides some advantages. With the help of this situation, the causal directions between these items can be considered; thus, it is possible to determine the most accurate strategies. The findings demonstrate that providing tax advantages is the most important factor in ensuring stock market efficiency. Moreover, the excellence of the financial system is critical in ensuring stock market efficiency. In this context, it is possible to provide tax advantages, especially for long-term investments. Thus, long-term investments can be increased, significantly increasing the market’s stability.