bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Potentially Protective Effects of Anti-Lipid, Hypoglycemic, and Anti-Hypertensive Agents for Perioperative Mortality in Geriatric Group
Authors: Tsai Feng-Fang , Lin Jou-Wei , Chang Sheng-Nan , Chu Chun-Lin , Lai Ling-Ping , Hwang Juey-Jen , Yeh Huei-Ming 
Published: January 2022

Abstract
Background
Great efforts were made to collect information and identify risk factors in predicting post-anesthetic mortality. In this study, we use national health insurance data base, including medications, underlying comorbidities and surgical factors to assess the relationship between these factors and mortality after surgery.
Methods
This is a retrospective, population based study. The study population who underwent general anesthesia (GA) were retrieved from the National Health Insurance Research Database in Taiwan between January 1, 2005 and December 31, 2013. We classified the study patients into 4 major comparison groups by surgical procedures, including major organ transplantation (heart, liver, lung, kidney, or pancreas), CV surgery, major neurosurgery, and others according to the diagnostic codes of the international classification of diseases, ninth revision, clinical modification (ICD-9-CM) codes. We proposed a logistic regression model with valuable variables which can significantly predicts the post-anesthesia mortality. We also designed different models for 4 subgroups according the results.
Results
A total of 833,685 subjects were included in this study, and the most common comorbidity was hypertension. Age was an important determinant associated with post-operation mortality among different surgical types. Perioperative prescription could reduce risks of operation. The prediction model based on the preliminary training group also performed well in the validation group (AUROC=0.8753 for in-hospital mortality; AUROC= 0.8767 for 30-days mortality). A reliable predicting model can help anesthesiologists to decide the anesthesia method or monitors, as well as helping physicians to take care of their patients after operation.
Conclusions
While GA is commonly used for the majority of the patients undergoing operations, the prediction model that we proposed from this nationwide study could identify the predictors for post-operation mortality. The potentially protective effects of anti-lipid, hypoglycemic, and anti-hypertensive agents were encouraging in geriatric preoperative group. It is expected that applying this prediction model and prescription into clinical practice could improve surgical risk stratification and further improve patient outcomes.
Trial registration
The protocol of this study was approved by the National Taiwan University Hospital Research Ethics Committee (Trial Registration 201411078RINC). Informed consent was waived by the National Taiwan University Hospital Research Ethics Committee due to the retrospective and anonymous nature of the claims data.
Bacterial Sensitivity To Chlorhexidine and Povidone-Iodine Antiseptics Over Time: A Systematic Review and Meta-Analysis of Human-Derived Data
Authors: Aftab Raiyyan , Dodhia Vikash H , Jeanes Christopher , Wade Ryckie G 
Published: January 2022

Abstract
Background
Surgical site infection (SSI) is the most common complication of surgery, increasing healthcare costs and hospital stay. Chlorhexidine (CHX) and povidone-iodine (PVI) are used for skin antisepsis, minimising SSIs. There is increasing concern of developing resistance to topical biocides, though clinical implications remain unclear.
Outcomes:
Determining whether the Minimum Bactericidal Concentration (MBC) for topical preparations of CHX or PVI have changed over time, in microbes relevant to SSI.
Methods
We included studies reporting the mean bactericidal concentration (MBC) of laboratory and clinical isolates of common microbes to CHX and PVI. Excluding non-human samples and studies using antimicrobial solvents or mixtures with other active substances. MBC was pooled in random effects meta-analyses. Change in MBC over time was explored using meta-regression.
Results
79 studies were including, analysing 6218 microbes over 45 years. Most used CHX (93%), with insufficient data for meta-analysis of PVI. There was no change in MBC of CHX to Staphylococci (β 0.12 [-1.13, 1.37]; I2 99%) or Streptococci (β 0.13 [-0.35, 0.62]; I2 97%).
Conclusions
There is no evidence of reduced susceptibility of common SSI-causing microbes to CHX over time. Providing reassurance that the worldwide guidance that CHX should remain the first-choice agent for surgical skin antisepsis.
Electronic, Magnetic and Optical Properties of Transition Metal Doped Nd2O3: A DFT Insight
Authors: Banerjee Priyanka , Mukhopadhyay Kausik 
Published: January 2022

Abstract

The structural, electronic, magnetic and optical properties of transition metal doped rare earth neodymium sesquioxide (Nd2XO3, where X = Co, Cr, Mn, Ni and Zn) was investigated here by first-principles simulations considering the density functional theory (DFT) framework. Comparing with the energy band structures, density of states and the overall charge density distribution, we find that the transition metal doping improves the application of the Nd2O3 (NDO) in many technological aspects. Spin-polarized calculations are quite satisfactorily described, and from this theoretical interpretation using DFT we fruitfully explain the mechanism behind the magnetic behavior of all doped samples. Electronic and optical properties of doped NDO samples are well tuned by transition metal atoms. Finally, we have seen that the values of total magnetization of transition metal substituted NDO samples are substantially enhanced compared to that of pure NDO.
Optimal Conditions of Paint Wastewater Coagulation With Gastropod Shell Conchiolin Using Response Surface Design and Artificial Neural Network-Genetic Algorithm
Authors: Ejimofor M.I , Ezemagu I.G , Menkiti M.C , Ugonabo V.I , Ejimofor B.U 
Published: January 2022

Abstract
The potential of gastropod shell conchiolin (GSC) (a waste product of the deprotenization stage of chitosan production) as one of the alternatives to chemical coagulants has been explored for treatment of paint industrial wastewater (PW). The accuracy of response surface design (RSD) and the precision of artificial intelligence (AI) in predicting and optimizing the process conditions were harnessed in raising experimental design matrix and response optimization, respectively for the bench scale jar test coagulation experiment. PW was characterized using American public health association (APHA) standard methods. Extraction of conchiolin was done via alkaline extraction method. PW contains 2098mg/l total suspended solid (TSS) above discharge limit (1905mg/l). Fourier transform infrared (FTIR) spectrum of GSC revealed a broad N–H wagging band at 750 – 650 cm−1 indicating the presence of secondary amine linked to the presence of protein. Turbidity removal from PW via one factor at a time (OFAT) was found to be a function of pH, GSC dosage, temperature and time. Artificial neural network (ANN) response prediction shows 92% correlation with the response surface design (RSD) experimental result. The optimal conditions obtained via genetic algorithm (GA) for the response optimization at the best pH of 4 indicate optimal turbidity removal of 98% at GSC dosage, time and temperature of 4 g, 20 min and 45oC, respectively.
Evaluation of Gait Characteristics in Subjects With Locomotive Syndrome Using the Wearable Gait Sensors
Authors: Saito Yuki , Ishida Tomoya , Kataoka Yoshiaki , Takeda Ryo , Tadano Shigeru , Suzuki Teppei , Nakamura Kentaro , Nakata Akimi , Osuka Satoshi , Yamada Satoshi , Samukawa Mina , Tohyama Harukazu 
Published: January 2022

Abstract
Background: Locomotive syndrome (LS) is a condition where a person requires nursing care services due to problems with locomotive abilities and musculoskeletal systems. Individuals with LS have a reduced walking speed compared to those without LS. However, differences in lower-limb kinematics and during walking between individuals with and without LS are not fully understood. The purpose of this study is to clarify the characteristics of gait kinematics using wearable sensors for individuals with LS.Methods: We assessed 125 people aged 65 years and older who utilized a public health promotion facility. The participants were grouped into Non-LS, LS-stage 1, LS-stage 2 (large number indicate worse locomotive ability) based on 25-question Geriatric Locomotive Function Scale (GLFS-25). Spatiotemporal parameters and lower-limb kinematics during 10-m walking test were analyzed by 7-inertia-sensors based motion analysis system. Peak joint angles during stance and swing phase as well as gait speed, cadence and step length were compared among all groups.Results: The number of each LS stage was 69, 33, 23 for Non-LS, LS-stage 1, LS-stage 2, respectively. LS-stage2 group showed significantly smaller peak hip extension angle, hip flexion angle and knee flexion angle than Non-LS group (hip extension: Non-LS: 9.5 ± 5.3°, LS-stage 2: 4.2 ± 8.2°, P = 0.002; hip flexion: No-LS: 34.2 ± 8.8°, LS-stage 2: 28.5 ± 9.5°, P = 0.026; knee flexion: Non-LS: 65.2 ± 18.7°, LS-stage 2: 50.6 ± 18.5°, P = 0.005). LS-stage 1 and LS-stage 2 groups showed significantly slower gait speed than Non-LS group (Non-LS 1.3 ± 0.2 m/s, LS-stage1 1.2 ± 0.2 m/s, LS-stage2 1.1 ± 0.2 m/s, P < 0.001).Conclusions: LS-stage2 group showed significantly different lower-limb kinematics compared with Non-LS group including smaller hip extension, hip flexion and knee flexion. The intervention based on these kinematic characteristics measured by wearable sensors would be useful to improve the locomotive ability for individuals classified LS-stage2.
Early and Strong Antibody Responses to SARS-CoV-2 Predict Disease Severity in COVID-19 Patients
Authors: Plūme Jānis , Galvanovskis Artis , Šmite Sindija , Romanchikova Nadezda , Zayakin Pawel , Linē Aija 
Published: January 2022

Abstract
Background
Antibody response to SARS-CoV-2 is a valuable biomarker for the assessment of the spread of the virus in a population and evaluation of the vaccine candidates. Recent data suggest that antibody levels also may have a prognostic significance in COVID-19. Most of the serological studies so far rely on testing antibodies against spike (S) or nucleocapsid (N) protein, however antibodies can be directed against other structural and nonstructural proteins of the virus, whereas their frequency, biological and clinical significance is unknown.
Methods
A novel antigen array comprising 30 SARS-CoV-2 antigens or their fragments was developed and used to examine IgG, IgA, IgE and IgM responses to SARS-CoV-2 in sera from 103 patients with COVID-19 including 34 patients for whom sequential samples were available, and 20 pre-pandemic healthy controls.
Results
Antibody responses to various antigens are highly correlated and the frequencies and peak levels of antibodies are higher in patients with severe/moderate disease than in those with mild disease. This finding supports the idea that antibodies against SARS-CoV-2 may exacerbate the severity of the disease via antibody-dependent enhancement. Moreover, early IgG and IgA responses to full length S protein may be used as an additional biomarker for the identification of patients who are at risk of developing severe disease. Importantly, this is the first study reporting that SARS-CoV-2 elicits IgE responses and their serum levels positively correlate with the severity of the disease thus suggesting a link between high levels of antibodies and mast cell activation.
Conclusions
This is the first study assessing the prevalence and dynamics IgG, IgA, IgE and IgM responses to multiple SARS-CoV-2 antigens simultaneously. Results provide important insights into the pathogenesis of COVID-19 and have implications in planning and interpreting antibody-based epidemiological studies.
A Bolder Conservation Future for Indonesia: Conserving Biodiversity, Carbon And Unique Ecosystem In Sulawesi
Authors: Pusparini Wulan , Cahyana Andi , Grantham Hedley , Maxwell Sean , Soto-Navarro Carolina , Andayani Noviar , Macdonald David , Linkie Matthew 
Published: January 2022

Abstract
As more ambitious protected area (PA) targets for the post-2020 global biodiversity framework is set beyond Aichi Target 11, new spatial prioritisation thinking is required to expand protected areas to maximise different environmental values. Our study focuses on the biodiversity and forest-rich Indonesian island of Sulawesi, which has a terrestrial PA network that covers 10% of the island. We run scenarios to identified areas outside the current PA network and their representativeness of conservation features. We use Marxan to investigate trade-offs in the design of a larger PA network with varying coverage targets (17%, 30%, and 50%) that prioritises forest area, karst ecosystem, and carbon value as conservation features. Our first scenario required PAs to be selected at all times, and it required larger areas to meet these targets than our second scenario, which did not include existing PAs. The vast Mekongga, Banggai, and Popayato-Paguat landscapes were consistently identified as high priorities for protection in the various scenarios. The final section of our analysis used a spatially explicit three-phase approach to achieve this through PA expansion, the creation of new PAs, and the creation of corridors to connect existing PAs. Our findings identified 13,039 km2 of priority areas to be included in the current PA network, potentially assisting Indonesia in meeting the post-2020 GBF target if our approach is replicated elsewhere across Indonesia as a national or sub-national analysis like this study. We discuss various land management options through OECMs and the costs to deliver this strategy.
Research on the Formation Mechanism of Surface Morphology in Three-Excitation Ultrasonic Spatial Vibration-Assisted Turning
Authors: Duan Jingwei , Zou Ping , Wei Shiyu , Fang Rui , Fang Liting 
Published: January 2022

Abstract
To improve the machining performance of different processing materials, a three-excitation ultrasonic spatial vibration-assisted turning system is proposed, which realizes the non-unity of the plane where the cutting trajectory of the tool is located. The influence and formation law of three-excitation ultrasonic spatial vibration-assisted turning on the surface roughness of the workpiece under different vibration parameters (amplitude) and machining parameters (cutting speed, cutting depth, and feed) were analyzed by response surface methodology. The results show that in terms of vibration parameters, the influence of ultrasonic vibration applied in the horizontal direction on surface roughness is significantly greater than that of ultrasonic vibration applied in the vertical direction, while the feed has the greatest influence on surface roughness, followed by cutting speed. The surface roughness of common turning, one-dimensional ultrasonic vibration-assisted turning, ultrasonic elliptical vibration-assisted turning, and three-excitation ultrasonic spatial vibration-assisted turning were theoretically analyzed and experimentally compared. The results show that compared with the other three turning methods, the three-excitation ultrasonic spatial vibration-assisted turning can obtain a lower surface roughness and have good machinability.
Derivations of Equality Algebras
Authors: Rezaei Gholam Reza , Kologani Mona Aaly , Borzooei Rajab Ali , Takallo Mohammad Mohseni 
Published: January 2022

Abstract
In this paper, we introduced the concept of derivation on equality algebra E by using the notions of inner and outer derivations. Then we investigated some properties of (inner, outer) derivation and we introduced some suitable conditions that they help us to define a derivation on E. We introduced kernel and fixed point sets of derivation on E and prove that under which condition they are filters of E. Finally we prove that the equivalence relations on (E,⇝, 1) coincide with the equivalence relations on E with derivation d.(2010) MSC: 03G25, 06B10, 06B99.
Public Understanding on Rip Currents and Beach Safety at Teluk Cempedak Recreational Beach of Pahang, Malaysia
Authors: Ramli Muhammad Zahir , Aliziyad Yusairah Amani Mohd , Mohamed Juliana , Othman Siti Fairuz Che , Yusof Muhammad Zubir , Pa'suya Muhammad Faiz , Ghafar Abdul Nasir Abdul , Jabbar Waheb A. 
Published: January 2022

Abstract
A cross-sectional study was conducted to examine the public understanding of rips currents at Teluk Cempedak Recreational Beach of Pahang, Malaysia, from November 2020 to March 2021 via a questionnaire survey. Convenient sampling was used to collect data from 300 respondents. The questionnaire consisted of 24 questions, encompassing five sections, i.e., the demographic background, frequency of visiting the beach, swimming ability, their knowledge of rip currents, and understanding of beach safety. Associations between the study variables and the knowledge of both rip currents and beach safety were evaluated using the independent sample t-test, Chi-square test, and multiple logistic regressions at the confidence level of 0.05. In general, only 86% of the respondent knew about the rip currents. For beach safety knowledge, 83% of the respondents on the lifeguard facilities, 44% for the yellow red-flag and 93.7% for the red flag. Variables such as gender (knowledge of rip currents: Adjusted Odds Ratio (AOR) = 0.647, 95% confidence interval (CI) = 0.487 - 0.60, p = 0.003; beach safety: AOR = 0.665, 95% CI = 1.14 - 5.02, p = 0.021), locality (knowledge of rip currents: AOR = 2.482, 95% CI = 1.407 - 4.380, p = 0.002, beach safety: AOR = 1.821, 95% CI = 1.022 - 3.245, p = 0.042), and respondents’ experience of having problems in water activities (knowledge of rip currents: AOR = 0.170, 95% CI = 0.635 - 6.379, p = 0.000) were significantly associated with the knowledge of both rip currents and beach safety. Further studies are essential to enhance public understanding of rip currents and hence the beach safety in Malaysia.
Recurrent Nephrotic Plasma Activates Pro-fibrotic Signalling Pathways Downstream of Protease-activated Receptor 1
Authors: Chesor Musleeha , Tuffin Jack , May Carl , Ghobrial Irene , Little Melissa , Welsh Gavin , Saleem Moin 
Published: January 2022

Abstract

Recurrence of steroid-resistant nephrotic syndrome (SRNS) is thought to be due to an unknown “circulating factor”, the identity of which has so far remained elusive. Our previous work suggests a signaling role for protease-activated receptor-1 (PAR-1), leading to impaired podocyte function. Here, we show that relapse nephrotic plasma (NP), but not paired remission plasma, induced a pro-fibrotic response. This change was inhibited by PAR-1 inhibitors, but not by TGF-β1 inhibition. Four PAR-1 inhibitors demonstrated distinct antagonistic properties. The phosphorylation of VASP and JNK in a 3D spheroid model (GlomSpheres) and kidney organoids corroborated the finding from a 2D ciPods model. Functionally, relapse NP induced podocyte motility, and podocyte loss from spheroids both of which were also selectively rescued by PAR-1 inhibitors. Also, it induced the loss of podocyte-specific markers in kidney organoids. We propose that the circulating factor acts as a pro-fibrotic effector by activating PAR-1, leading to increased podocyte injury.
IL-1β Promotes A7r5 and HASMC Migration and Invasion via the p38-MAPK/Ang2 Pathway
Authors: Xu anyu , Pei jingchun , Yang Yunhong , Hua Baotong , Wang Jing 
Published: January 2022

Abstract
Background: The migration, proliferation, and inflammatory factor secretion of vascular smooth muscle cells (VSMCs) are involved in the important pathological processes of several vascular occlusive diseases, including coronary atherosclerosis (CAS). IL-1β, as a bioactive mediator of VSMC synthesis and secretion, can promote the pathological progress of CAS. In this study, we further explored the underlying molecular mechanisms by which IL-1β regulates VSMC migration, invasion.Methods: We pretreated A7r5 and HASMC with IL-1β for 24 hours, and measured the expression of IL-1β, PCNA, cyclin D1, MMP2 and MMP9 in the cells by Western blotting. Cell migration and invasion ability were measured by Transwell and wound healing assays. Cell viability was measured by an MTT assay. Results: We found that IL-1β up-regulated the expression of proliferation-related proteins (PCNA and Cyclin D1) in A7r5 and HASMC, and induces the secretion of MMP2 and MMP9, promotes cell invasion and migration. In addition, in A7r5 and HASMCs treated with IL-1β, the expression of Ang2 increased in a time-dependent manner, transfection with si-Ang2 suppressed cell migration and invasion, with down-regulated MMP2 and MMP9 expression. In parallely, we further found that the p38-MAPK pathway is activated in cells induced by IL-1β, p38-MAPK inhibitors can down-regulate the expression of Ang2. Conclusions: These data demonstrated that IL-1β promotes A7r5 and HASMC migration and invasion via the p38-MAPK/Ang2 pathway.
AlG3 Induces AURKA to Promote Laryngeal Squamous Cell Carcinoma Metastasis
Authors: huang shuixian , YANG Li-Yun , Qiao Peipei , Hu An 
Published: January 2022

Abstract
Objectives To investigate the relationship between ALG3 and AURKA, the expression and potential prognostic value of ALG3 in LSCC, and to then explore the impact of ALG3 in tumorigenic effects.Methods Co-immunoprecipitation assay was detected the relationship between ALG3 and AURKA, Rt-PCR and Western blot was detected the expression of related mRNA and proteins. CCK8 assay, plate colony formation assay Cells, wound healing, migration and invasion assays were used to examine the ability of proliferation, movement, migration and invasion of LSCC cells.Results ALG3 immediately induced AURKA to promote LSCC metastasis. Moreover, ALG3 highly expressed in LSCC tissues and cells and the expression of ALG3 was positively related to tumor size, lymphatic metastasis and poor clinical prognosis. Furthermore, knockdown ALG3 in LSCC cells remarkably restrain cellular proliferation, migration and invasion in vitro and vivo.Conclusion AlG3 induced AURKA to promote LSCC metastasis and ALG3 maybe potential prognostic value for LSCC.Brief AbstractAlG3 induces AURKA to promote laryngeal squamous cell carcinoma metastasis
Large crop production losses induced by global ozone stress based on interval evaluation
Authors: Cai Andong , Wang Bin , Ren Tianjing , Zhang Wenju , Wang Xiaoke , Dong Hongmin , Li Yue 
Published: January 2022

Abstract
Global crop yield loss due to ground-level ozone (O3) concentrations is a major challenge to food security, but a dose-response association is not easy to quantify. Here, we propose using a new metric, O3 sensitivity of crop yield (Yo), to estimate yield loss under different O3 time intervals using four observational databases. The Yo metric shows a non-linear parabola with elevated atmospheric O3 for wheat, maize, rice, soybean, and assorted vegetables. Spatial heterogeneity of yield loss varies as a function of crop type and O3 intervals. Estimates of yield loss from ozone suggest recent losses (2017-2019) may reach as high as 537 million tonnes, with a significant proportion coming with lower (30-40 ppb) exposure (325 million tonnes). Our results suggest that previous research, which only included higher (>40 ppb ozone), may have had grossly underestimated the negative effect of atmospheric O3 on crop production. Suppose these results are endemic to global crop production. In that case, additional research will be necessary to reassess ozone sensitivity and dose-responses, both spatially and temporally, to determine future air pollution impacts.