bluuebunny/crossref_metadata_2025_split huggingface dataset:
Do Genetic Polymorphisms Affect Fetal Hemoglobin (HbF) Levels in Patients With Sickle Cell Anemia Treated With Hydroxyurea? A Systematic Review and Pathway Analysis
Authors: Sales Rahyssa Rodrigues , Nogueira Bárbara Lisboa , Tosatti Jéssica Abdo Gonçalves , Gomes Karina Braga , Luizon Marcelo Rizzatti 
Published: January 2022

Hydroxyurea has long been used for the treatment of sickle cell anemia (SCA), and its clinical effectiveness is related to the induction of fetal hemoglobin (HbF), a major modifier of SCA phenotypes. However, there is substantial variability in response to hydroxyurea among patients with SCA. While some patients show an increase in HbF levels and an ameliorated clinical condition under low doses of hydroxyurea, other patients present a poor effect or even develop toxicity. However, the effects of genetic polymorphisms on increasing HbF levels in response to hydroxyurea in patients with SCA (Hb SS) have been less explored. Therefore, we performed a systematic review to assess whether single-nucleotide polymorphisms (SNPs) affect HbF levels in patients with SCA treated with hydroxyurea. Moreover, we performed pathway analysis using the set of genes with SNPs found to be associated with changes in HbF levels in response to hydroxyurea among the included studies. The systematic literature search was conducted on Medline/PubMed, EMBASE, Cochrane Central Register of Controlled Trials, Cumulative Index to Nursing and Allied Health Literature (CINAHL), Scopus, and Web of Science. Seven cohort studies were included following our inclusion and exclusion criteria. From the 728 genetic polymorphisms examined in the included studies, 50 different SNPs of 17 genes were found to be associated with HbF changes in patients with SCA treated with hydroxyurea, which are known to affect baseline HbF but are not restricted to them. Enrichment analysis of this gene set revealed reactome pathways with the lowest adjusted p-values and highest combined scores related to VEGF ligand–receptor interactions (R-HSA-194313; R-HSA-195399) and the urea cycle (R-HSA-70635). Pharmacogenetic studies of response to hydroxyurea therapy in patients with SCA are still scarce and markedly heterogeneous regarding candidate genes and SNPs examined for association with HbF changes and outcomes, suggesting that further studies are needed. The reviewed findings highlighted that similar to baseline HbF, changes in HbF levels upon hydroxyurea therapy are likely to be regulated by multiple loci. There is evidence that SNPs in intron 2 of BCL11A affect HbF changes in response to hydroxyurea therapy, a potential application that might improve the clinical management of SCA.Systematic Review Registration: (https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=208790).
Exploring Access to Mental Health and Primary Care Services for People With Severe Mental Illness During the COVID-19 Restrictions
Authors: Newbronner Elizabeth , Spanakis Panagiotis , Wadman Ruth , Crosland Suzanne , Heron Paul , Johnston Gordon , Walker Lauren , Gilbody Simon , Peckham Emily 
Published: January 2022

AimsTo explore: how satisfied people with severe mental illness (SMI) are with the support received during the pandemic; understand any difficulties encountered when accessing both mental health and primary care services; consider ways to mitigate these difficulties; and assess the perceived need for future support from mental health services.Materials and MethodsA representative sample was drawn from a large transdiagnostic clinical cohort of people with SMI, which was recruited between April 2016 and March 2020. The sample was re-surveyed a few months after the beginning of the restrictions. Descriptive frequency statistics were used to analyze the quantitative data. The free text responses were analyzed thematically.Results367 participants responded to the survey. Two thirds were receiving support from mental health services with the rest supported in primary care or self-managing. A quarter thought they would need more mental health support in the coming year. Half had needed to used community mental health services during the pandemic and the majority had been able to get support. A minority reported that their mental health had deteriorated but they had either not got the supported they wanted or had not sought help. The biggest service change was the reduction in face-to-face appointments and increasing use of phone and video call support. Nearly half of those using mental health services found this change acceptable or even preferred it. However, acceptability was influenced by several factors, and participants were more likely to report that they had received all the support they needed, when seen in person.DiscussionAlthough most participants were satisfied with the mental health support they had received, a minority were not. This, couple with findings on future need for mental health support has implications for post pandemic demand on services. Remote care has brought benefits but also risks that it could increase inequalities in access to services.
Association of Fear of COVID-19 and Health Literacy Among the General Public in Saudi Arabia: A Cross-Sectional Assessment
Authors: Moussa Mahaman L. , Moussa Fatchima Laouali , Alharbi Homood A. , Omer Tagwa , Sofiany Hussain Ahmad , Almuzaini Tarraji Mohammed , Alsaady Eissa Salem , Alrashede Sattam Musleh 
Published: January 2022

ObjectiveThis study aims to determine the level of fear of coronavirus disease—2019 (COVID-19) among the general public in Saudi Arabia and the association of its scores with their level of health literacy.MethodsA descriptive cross-sectional study was conducted among the general population in Saudi Arabia from April 2020 to May 2020. A three-part online self-reported survey was used to assess the participants' demographic characteristics, fear of COVID-19 of the participants, and levels of health literacy.ResultsOf the 848 participants, 56.8% were in the age group of 25–34, 45.6% were females, and 57.1% had a bachelor's degree. The total mean score of the fear of COVID-19 scale of the participants was FCoV-19: mean ± SD = 19.60 ± 7.33 and the health literacy was HL index: mean ± SD = 27.57 ± 11.05. There was a significant difference in the scores of fear of COVID-19 scale in terms of age (F = 2.442, p = 0.050), representing that those aged 45 and above had higher mean fear scores than the younger participants. The analysis revealed that an increased level of fear of COVID-19 was associated with older age (B = 1.87; p = 0.020), being unemployed (B = 0.76; p = 0.023), with no formal education (B = 0.89; p = 0.001), and low level of health literacy (B = 0.02; p = 0.021).ConclusionThe study shows an above-average level of fear of COVID-19 of the general public in Saudi Arabia and its association with a low level of functional health literacy. Timely and comprehensive health interventions should be promoted to enhance the level of health literacy and further reduce the level of fear of COVID-19 in the community.
Positive Rate of Human Papillomavirus and Its Trend in Head and Neck Cancer in South Korea
Authors: Jun Hyun Woong , Ji Yong Bae , Song Chang Myeon , Myung Jae Kyung , Park Hae Jin , Tae Kyung 
Published: January 2022

IntroductionThis study aimed to investigate the positive rate of human papillomavirus (HPV) and its trend in head and neck squamous cell carcinoma (HNSCC) in South Korea and to evaluate the clinical differences between HPV-positive and -negative tumors.MethodsWe studied 300 patients with HNSCC arising in the oropharynx (n = 77), oral cavity (n = 65), larynx (n = 106), hypopharynx (n = 40), and sinonasal cavity (n = 12), treated in a tertiary university hospital in South Korea from January 2008 to July 2020. HPV status was determined using p16 immunohistochemical staining of formalin-fixed paraffin-embedded tissues.ResultsOf the 300 patients with HNSCC, the positive rate of p16 was 30.3% (91/300). The p16 positive rate was 70.1, 13.9, 20.8, 15, and 0% in the oropharynx, oral cavity, larynx, hypopharynx, and sinonasal cavity, respectively. HPV-positive oropharyngeal squamous cell carcinoma (OPSCC) patients were significantly younger than HPV-negative OPSCC patients. The positive rate of HPV in OPSCC has increased over time from 2008 to 2020, but has not changed significantly in the other primary sites. The disease-free survival curve of HPV-positive OPSCC was significantly better than that of HPV-negative tumors.ConclusionThe positive rate of HPV in Korean patients with OPSCC is significantly high (70.1%), similar to that in North America and Europe, and has increased abruptly in the past 12 years.
Salviolone from Salvia miltiorrhiza Roots Impairs Cell Cycle Progression, Colony Formation, and Metalloproteinase-2 Activity in A375 Melanoma Cells: Involvement of P21(Cip1/Waf1) Expression and STAT3 Phosphorylation
Authors: Zanrè Valentina , Campagnari Rachele , Cerulli Antonietta , Masullo Milena , Cardile Alessia , Piacente Sonia , Menegazzi Marta 
Published: January 2022

Melanoma is a highly malignant solid tumor characterized by an elevated growth and propagation rate. Since, often, melanoma treatment cannot prevent recurrences and the appearance of metastasis, new anti-melanoma agents need to be discovered. Salvia miltiorrhiza roots are a source of diterpenoid derivatives, natural compounds with several biological activities, including antiproliferative and anticancer effects. Seven diterpenoid derivatives were purified from S. miltiorrhiza roots and identified by NMR and MS analysis. Tanshinone IIA and cryptotanshinone were detected as the main components of S. miltiorrhiza root ethanol extract. Although their antitumor activity is already known, they have been confirmed to induce a reduction in A375 and MeWo melanoma cell growth. Likewise, salviolone has been shown to impair the viability of melanoma cells without affecting the growth of normal melanocytes. The underlying anticancer activity of salviolone has been investigated and compared to that of cryptotanshinone in A375 cells, showing an increased P21 protein expression in a P53-dependent manner. In that way, salviolone, even more than cryptotanshinone, displays a multitarget effect on cell-cycle-related proteins. Besides, it modulates the phosphorylation level of the signal transducer and activator of transcription (STAT)3. Unexpectedly, salviolone and cryptotanshinone induce sustained activation of the extracellular signal-regulated kinases (ERK)1/2 and the protein kinase B (Akt). However, the blockage of ERK1/2 or Akt activities suggests that kinase activation does not hinder their ability to inhibit A375 cell growth. Finally, salviolone and cryptotanshinone inhibit to a comparable extent some crucial malignancy features of A375 melanoma cells, such as colony formation in soft agar and metalloproteinase-2 activity. In conclusion, it has been shown for the first time that salviolone, harboring a different molecular structure than tanshinone IIA and cryptotanshinone, exhibits a pleiotropic effect against melanoma by hampering cell cycle progression, STAT3 signaling, and malignant phenotype of A375 melanoma cells.
EQUATIONS OF NONLINEAR PROBLEMS OF COMPACTION OF ELASTIC-CREEPING INHOMOGENEOUS SOILS
Authors: Дасибеков А. , Айменов Ж. Т. , Арапов Б. , Мырзалиев Д. С. 
Published: January 2022

Поведение грунта в области нелинейной ползучести весьма сложно и изучено недостаточно полно, поэтому в настоящее время крайне необходимы всесторонние и углубленные экспериментальные и теоретические исследования ползучести грунта при высоких напряжениях. Причем физически нелинейный характер ползучести грунта отчетливо проявляется как при ступенчатом повышении нагрузки, так и при загружении образцов постоянными сжимающими напряжениями различной величины. Исследование нелинейной задачи консолидации глинистых грунтов с учетом их ползучести в данной модели сводится к определению решений линейных интегро-дифференциальных уравнений.
He behavior of soil in the field of nonlinear creep is very difficult and insufficiently studied, so at present it is essential to conduct comprehensive and in-depth experimental and theoretical studies of soil creep at high stresses. Moreover, the physically nonlinear nature of the soil creep is clearly manifested both in the stepwise increase in the load and when loading samples with constant compressive stresses of various sizes. The study of the nonlinear problem of consolidation of clay soils taking into account their creep in this model is reduced to the definition of solutions of linear integro-differential equations.
Nanoionics-based neuromorphic function of a Pt/Ti0.96Co0.04O2-δ
/Pt multilayer device operating at low pulse voltage
Authors: Takada Tomoasa , Yamaguchi Yu , Taniguchi Mitsuki , Fukushima Yoshiaki , Ito Hiroki , Notake Go , Nishioka Daiki , Takayanagi Makoto , Higuchi Tohru 
Published: January 2022

Abstract
We investigated the nanoionics-based neuromorphic function of Pt/Ti0.96Co0.04O2−δ
/Pt multilayers with a cross-point structure prepared by RF magnetron sputtering. This multilayer exhibits electro-ion mixed conduction and a nonlinear current–voltage characteristic based on the Schottky barrier between Pt and Ti0.96Co0.04O2−δ
layers. When the low electrical pulse of 0.8 V was applied with a short interval time of 14 s, current modulation corresponding to the long-term memorization (LTM) was observed, though the current response at the long interval time of 80 s was the short-term memorization (STM). The O 1 s photoemission spectrum showed the OH− peak that contributes to the electron-ion mixed conduction. The current responses with both LTM and STM are considered to be due to the local proton migration at near the Schottky barrier.
Effects of X-ray accelerating voltage on electrical properties and reliability for ferroelectric random-access memory (FeRAM)
Authors: Lin Hsin-Ni , Chang Ting-Chang , Chen Wen-Chung , Tan Yung-Fang , Chang Kai-Chun , Lin Shih-Kai , Yeh Yu-Hsuan , Wu Chung-Wei , Zhang Yong-Ci , Yeh Chien-Hung , Lee Ya-Huan , Huang Jen-Wei 
Published: January 2022

Abstract
This work investigates the effect of X-ray accelerating voltage (V
acc) on the structural repair of HfZrOx ferroelectric random-access memory. We found that X-rays are able to break the molecular bonds due to missing electrons, thereby repairing the material structure. To further understand the influence of X-ray V
acc on structural repair, we conducted different V
acc conditions, with results showing that there is only a small improvement under high V
acc. However, the improvement is much clearer under low V
acc. To illuminate these results, we propose a physical model which is based on different X-ray energies that will have different energy penetration capacities.
Upaya Meningkatkan Kemampuan Membaca Efektif Melalui Media Pembelajaran V-Resbu Bahasa Indonesia
Authors: Nyamat Nyamat 
Published: January 2022

<p><em>L</em><em>atar belakang</em><em> </em><em> penelitian ini adalah </em><em>siswa belum aktif </em><em>serta</em><em> </em><em>rendahnya hasil belajar siswa </em><em>membaca efektif dalam memberi komentar pada buku fiksi maupun nonfiksi</em><em> dalam pembelajaran </em><em>bahasa Indonesia</em><em> </em><em>pada siswa kelas VII J SMP Negeri 3 Pati pada Tahun Pelajaran 2021/2022. Tujuan penelitian tindakan kelas ini untuk mengetahui peningkatkan aktivitas siswa dan kemampuan me</em><em>beri</em><em>kan tanggapan terhadap isi buku fiksi nonfiksi dengan membuat media pembelajaran V-Resbu pada siswa kelas VII SMP Negeri 3 Pati pada tahun pelajaran 2021/2022. Hipotesis tindakan menyatakan melalui media pembelajaran V-Resbu siswa lebih aktif serta nilai kemampuan menyajikan tanggapan terhadap isi buku fiksi nonfiksi pada siwa kelas VII J SMP Negeri 3 Pati pada tahun pelajaran 2021/2022 dapat ditingkatkan. Subjek dalam penelitian ini adalah siwa kelas VII J SMP Negeri 3 Pati yang berjumlah 22 siswa. </em><em>Waktu yang dibutuhkan mulai merencanakan sampai menyusun laporan adalah selama </em><em>dua</em><em> bulan, yaitu mulai bulan </em><em>Januari</em><em> sampai dengan bulan </em><em>Februari</em><em> tahun 2020. Pengumpulan data menggunakan teknik tes, dan non tes. Untuk data kuantitatif yaitu tentang hasil belajar dianalisis dengan menggunakan Analisis Deskriptif Komparatif yaitu membandingkan hasil belajar kondisi awal dengan siklus I, kemudian siklus I dengan siklus II, dan siklus I dengan kondisi akhir. Berdasarkan hasil penelitian dapat disimpulkan bahwa dengan me</em><em>manfaatkan media pembelajaran V-Resbu </em><em>nerapkan metode demostrasi dan latihan dapat meningkatkan hasil belajar siswa dalam mata pembelajaran </em><em>bahasa Indonesia</em><em> tentang </em><em>memberi komentar pada buku fiksi maupun nonfiksi</em><em> bagi siswa kelas </em><em>VII J SMP Negeri 3 Pati pada tahun pelajaran 2021/2022.</em></p>
Perbandingan Motivasi Belajar Bahasa Inggris Antara Siswa Kelas X-IPA dan Kelas X-IPS
Authors: Hidayah Yulianti , Zannah Fathul , Lestari Nana Citrawati 
Published: January 2022

<p>Often science (IPA) students tend to be considered smart and diligent in studying, but is the motivation of students majoring in science also higher than students majoring in social studies (IPS)? Based on the above thoughts, the researcher is interested in knowing how to compare the motivation to learn English between students in class X-IPA science and grade X-IPS social studies at SMAN 5 Banjarmasin. The purpose of this study was to determine the comparison of students' motivation to learn English between students in class X-IPA and class X social studies at SMAN 5 Banjarmasin. The comparison of motivation focuses on integrative motivation and instrumental motivation. The type of research used in this research is descriptive research. The data of this study were sourced from primary data collected through a google form questionnaire/questionnaire. The data analysis technique used is the descriptive percentage analysis method by calculating the frequency and percentage of answers to each item in the questionnaire. Based on the conclusion, it is known that the integrative learning motivation and the instrumental learning motivation of students in class X-IPA are lower than students in class X social studies.</p>
Penguatan Kelembagaan Desa Wisata melalui Promosi Digital Marketing di Desa Cisaat, Kecamatan Ciater, Kabupaten Subang
Authors: Abidin Jenal , Fedrina Rezka , Agustin Revi 
Published: January 2022

Strengthening Tourism Village Institutions through Digital Marketing Promotion in Cisaat Village, Ciater District, Subang Regency
An increase in the number of tourist visits to a destination is an indicator of the success of an effective marketing promotion strategy. The selection of an effective marketing promotion strategy that is in accordance with market trends is an absolute must. One of the effective media in the promotion of destination marketing is to use digital marketing media. Cisaat Tourism Village, Subang is one of the villages that makes tourism one of the sectors that drive the economy of its people. Cisaat Tourism Village has considerable potential including cultural tourism, nature tourism and educational tourism. Cisaat Tourism Village has a weakness in terms of marketing promotion so that the increase in the number of visits is not significant. Community service programs are expected to be the solution. The activities carried out were workshops on making tourist village websites, digital marketing workshops to increase knowledge and skills regarding interesting content for website marketing and social media marketing. The output of this activity is the availability of a marketing promotion website for tourism village packages, the skills of tourism village managers in creating social media marketing promotional content.
Integrasi Video Conference dalam Aplikasi Pembelajaran Siswa Sekolah Dasar untuk Kemudahan Interaksi dan Evaluasi Proses Belajar Mengajar Secara Daring
Authors: Hermanto Agus , Sidqon Mochamad 
Published: January 2022

Abstract - The rapid development of information technology is one of the most valuable potentials in efforts to improve the quality of education. With information technology, there is a lot of unlimited information that can be extracted for the benefit of the development of the world of education. SDN Karangsentul, which is the object of community service in this study, also does not escape and must be able to adapt to technological developments during teaching and learning activities. One form of implementing the use of technology in the world of education is an online teaching and learning system. In online learning, it is necessary to pay attention to the ease of interaction and evaluation in these learning activities. One of the efforts to improve the ease of interaction and evaluation of learning is by integrating online learning with the video conference feature. Based on these considerations to facilitate the interaction and evaluation of the online learning process, this community service activity will carry out the Integration of Video Conferences in Primary School Student Learning Applications for Ease of Interaction and Evaluation of the Online Teaching and Learning Process, so that online learning support can have a maximum impact on education development. In its construction, the SDLC method is used. And used white-box testing methods and BlackBox testing. The test results show that the system built works well and is able to answer existing problems.Keywords - Online, Education, Community Service, Information Technology, Video Conference. Abstrak - Teknologi informasi yang berkembang semakin pesat merupakan salah satu potensi berharga dalam upaya peningkatan kualitas pendidikan. Dengan teknologi informasi banyak sekali informasi yang tak terbatas yang dapat digali demi kepentingan perkembangan dunia Pendidikan. Salah satu bentuk implementasi pemanfaatan teknologi dalam dunia Pendidikan adalah sistem belajar mengajar daring. Dalam pembelajaran daring, perlu diperhatikan kemudahan interaksi dan evaluasi dalam kegiatan pembelajaran tersebut. Salah satu upaya untuk meningkatkan kemudahan interaksi dan evaluasi pembelajaran adalah dengan mengintegrasikan pembelajaran daring dengan fitur video conference. Berdasarkan pertimbangan tersebut dalam rangka mempermudah interaksi dan evaluasi proses pembelajaran daring, pada kegiatan pengabdian masyarakat ini akan dilaksanakan Integrasi Video Conferece Dalam Aplikasi Pembelajaran Siswa Sekolah Dasar Untuk Kemudahan Interaksi dan Evaluasi Proses Belajar Mengajar Secara Daring, sehingga dukungan pembelajaran daring dapat berdampak maksimal pada perkembangan Pendidikan. Pada pembangunannya digunakan metode SDLC. Serta digunakan metode pengujian whitebox dan blackbox testing. Hasil pengujian menunjukkan sistem yang dibangun berhasil dengan baik dan mampu menjawab permasalahan yang ada. Kata Kunci - Daring, Pendidikan, Pengabdian Masyarakat, Teknologi Informasi, Video Conference.