bluuebunny/crossref_metadata_2025_split huggingface dataset:
Autologous cord blood mononuclear cell infusion for the prevention of bronchopulmonary dysplasia in very preterm monozygotic twins: A study protocol for a randomized, placebo-controlled, double-blinded multicenter trial
Authors: Zhuxiao Ren , Ruoyu Huang , Liling Yang , Xuejun Ren , Chunhui Yang , Wanfen Ruan , Zhifeng Chen , Yiheng Dai , Qi Zhang , Wei Wei , Zhipeng Liu , Jingjun Pei , Qigai Yin , Jie Yang 
Published: December 2022

BackgroundPreterm-associated complications remain the main cause of neonatal death. Survivors face the challenges of short- and long-term complications. Among all complications, bronchopulmonary dysplasia (BPD) remains the first important cause of neonatal mortality and morbidity. Current treatment does not address this main preterm complication. Cord blood is regarded as a convenient source of stem cells. The paracrine bioactive factors of stem cells contribute to tissue repair and immune modulation. Our clinical studies and those of others have shown that cord blood cell infusion is both safe and possibly effective in the prevention and treatment of BPD. The therapeutic use of cord blood has emerged as a promising therapy. However, the genetic heterogeneity between control and intervention groups may reduce the comparability especially among small sample trials. The purpose of this study protocol is to investigate the effects of autologous cord blood mononuclear cell (ACBMNC) infusion on the prevention of BPD in very preterm monozygotic twins of less than 32 gestation weeks.MethodsIn this prospective, randomized, placebo-controlled, double-blinded multicenter clinical trial, 60 pairs of monozygotic twin preterm neonates of less than 32 weeks admitted to the Neonatal Intensive Care Unit are randomly assigned to receive intravenous ACBMNC infusion (targeted at 5 × 107 cells/kg) or placebo (normal saline) within 24 h after birth in a 1:1 ratio. The primary outcome will be survival without BPD at 36 weeks of postmenstrual age. The secondary outcomes will include the mortality rate, BPD severity, other common preterm complication rates, respiratory support duration, length and cost of hospitalization, and long-term respiratory and neurodevelopmental outcomes during a 2-year follow-up. Furthermore, we will perform single-cell RNA sequencing for cord blood cells and blood cells 3–10 days after intervention and detect whether reactive oxygen species and inflammatory cytokines are present.ConclusionThis will be the first randomized, placebo-controlled, double-blinded trial to evaluate the efficacy of ACBMNC infusion to prevent BPD in monozygotic twin premature infants and investigate the underlying protective mechanisms. The results of this trial will provide valuable clinical evidence for translational application of cord blood cell therapy in very preterm infants.Trial registration: ClinicalTrials.gov, NCT05087498, registered 10/09/2021, https://register.clinicaltrials.gov/prs/app/action/SelectProtocol?sid=S000BAD7&amp;selectaction=Edit&amp;uid=U0002PLA&amp;ts=2&amp;cx=qvyylv.
Continuous-wave terahertz quantum cascade laser based on a hybrid bound to bound quantum design
Authors: Li Weijiang , Li Yuanyuan , Ma Yu , Xu Yunfei , Liu Junqi , Zhuo Ning , Lu Quanyong , Wang Lijun , Zhang Jinchuan , Zhai Shenqiang , Liu Shuman , Liu Fengqi 
Published: December 2022

We report a low threshold power density and high power output terahertz quantum cascade laser emitting at ∼3.9 THz operating in continuous-wave mode. The high output power and wall-plug efficiency are achieved based on a hybrid bound-to-bound quantum active design. A record output power of 312 mW and a low threshold power density of 0.8 kW/mm3 (threshold current density of 109 A/cm2) in continuous-wave mode at 20 K is demonstrated for a 300-μm-wide and 2-mm-long single-ridge device. The highest wall-plug efficiency is 1.38% and the slope efficiency is 684 mW/A with an internal quantum efficiency of ∼120 photons per injected electron. The demonstration of this low-threshold and high-power THz laser will promote THz-based remote sensing and standoff detection for pharmaceutical and health industry applications.
Flight performance of pollen starved honey bees and incomplete compensation through ingestion after early life pollen deprivation
Authors: Brodschneider Robert , Omar Eslam , Crailsheim Karl 
Published: December 2022

We investigated the effect of adult honey bee pollen nutrition on the flight performance of honey bees. Therefore, caged bees were allowed to perform 30 min of defecation/training flights every second day before flight performance of pollen-fed bees and pollen-deprived bees older than 16 days were compared in a flight mill. We first fed 10 µL of 1 M glucose solution to bees, and after they metabolized this during flight, they were fed 10 µL of 2 M glucose solution for a second flight test. Pollen-deprived bees flew longer and further than pollen-fed bees in both flights. Pollen-fed bees flew faster in the early period at the beginning of flights, whereas pollen-deprived bees were faster in the final phases. Pollen-fed bees were able to raise their maximum flight speed in 2 M glucose solution flights, whereas pollen-constraint bees were not. The two groups did not differ in abdomen fresh weight, but the fresh weight of the head and thorax and dry weight of the head, thorax and abdomen were higher in pollen-fed bees. In a second experiment, we constrained pollen consumption of caged bees during the first 7 days and compared daily consumption of bees from day 8–16 to consumption of bees unrestricted in pollen. We found that pollen-deprived bees perceive the pollen shortage and try to compensate for their needs by consuming significantly more pollen at the later phase of their life than pollen-fed bees of the same age. Still, bees constrained from pollen in the first 7 days did only reach 51.1% of the lifetime consumption of unconstrained bees. This shows that bees can sense the need for essential nutrients from pollen, but their physiological apparatus does not allow them to fully compensate for their early life constraint. Pollen deprivation only in the first 7 days of worker life likewise significantly reduced fresh and dry weights of the body sections (head, thorax, and abdomen) and survival. This underlines the importance of protein consumption in a short critical period early in adult bees’ lives for their development and their performance later in life.
The effect of emotion regulation on happiness and resilience of university students: The chain mediating role of learning motivation and target positioning
Authors: Chen Xiaoxue , Huang Zejuan , Lin Wei 
Published: December 2022

ObjectiveTo investigate the effect andmechanism among emotion regulation, relationship,happiness, learning motivation, target positioning, and resilience of university students.MethodA total of 904 university students in China were included in this cross-sectional survey from April to May this year. The self-administered questionnaires, including the adapted Mental Health Scale with a Healthy Personality Orientation for College Students, were used to construct structural equations to test the chain mediating effects of learning motivation and target positioning based on a multi-stage whole group sample of university students.ResultEmotion regulation indirectly affected happiness through the mediating effect of interpersonal relationship (Med = −0.387, p = 0.001). Learning motivation and target positioning play the chain mediating role in the effect of emotion regulation on happiness (Med = −0.307, p = 0.001) and resilience (Med = −0.275, p = 0.001).ConclusionEmotion regulation indirectly affected happiness and resilience through the chain mediating effect of learning motivation and target positioning.
Effect of acute exercise intensity on cognitive inhibition and well-being: Role of lactate and BDNF polymorphism in the dose-response relationship
Authors: Ballester-Ferrer Juan Arturo , Bonete-López Beatriz , Roldan Alba , Cervelló Eduardo , Pastor Diego 
Published: December 2022

IntroductionThere is evidence in the literature that acute exercise can modify cognitive function after the effort. However, there is still some controversy concerning the most effective exercise modality to improve cognitive function in acute interventions. Regarding these different exercise modalities, the dose–response relationship between exercise intensity and cognitive response is one of the most challenging questions in exercise and cognition research.MethodsIn this study, we tested the impact of moderate-intensity (MICT), high-intensity (HIIT) exercise sessions, or control situation (CTRL) on cognitive inhibition (measured with the Stroop Test). Thirty-six young college students participated in this study, where a within-subject repeated measure design was used.ResultsANOVA 2×3 demonstrated that HIIT improved the acute cognitive response to a higher degree when compared to MICT or CTRL (p &lt; 0.05). The cognitive improvements correlated with lactate release, providing a plausible molecular explanation for the cognitive enhancement (r &lt; −0.2 and p &lt; 0.05 for all the Stroop conditions). Moreover, a positive trend in wellbeing was observed after both exercise protocols (HIIT and MICT) but not in the CTRL situation. Genetic BDNF single nucleotide polymorphism did not influence any interactions (p &lt; 0.05).DiscussionIn this sense, our results suggest that exercise intensity could be a key factor in improved cognitive function following exercise in young college students, with no additional impact of BDNF polymorphism. Moreover, our results also provide evidence that exercise could be a useful tool in improving psychological wellbeing.
Does the practice of mindfulness reduce somatic symptoms and COVID-19-related anxiety? A community-based survey
Authors: Micheli Noemi , Porcelli Piero , Barrault-Couchouron Marion , Dantzer Cécile 
Published: December 2022

ObjectiveSince the beginning of COVID-19 pandemic, several studies have shown an increase of psychological distress in the general population. Previous research demonstrated that high levels of anxiety are associated with reporting more somatic symptoms. The ability to adaptively regulate emotions is essential to deal with stressful situations, and it is one of the main components of mindfulness practice. The aim of the present study was to document the effect of mindfulness practice on somatic symptoms and psychological distress in the context of COVID-19 pandemic.MethodsThe study has a descriptive cross-sectional design. During the second wave of COVID-19 pandemic, between November 2020 and January 2021 participants living in France responded to an online survey on the impact of COVID-19 on psychological distress and physical health. The questionnaire included the assessment of COVID-19-related anxiety, mindfulness practice and experience, dispositional mindfulness, somatization, depression, generalized anxiety, and emotion regulation.ResultsA total of 569 people (mean age = 39.8 years, 90% women) were included in the study. COVID-19 related anxiety was associated with higher levels of somatic symptoms, generalized anxiety, and depression. About half of the sample (n = 318, 56%) reported moderate to severe somatic symptoms that were associated with higher levels of depression and anxiety, lower levels of dispositional mindfulness and to the use of maladaptive emotion regulation strategies. Overall, 164 subjects (28.8%) reported practicing meditation. No differences were found in dispositional mindfulness (MAAS score) between beginners and advanced practitioners, regardless of the type, years, frequency, and length of practice. Participants with less experience in mindfulness practice reported a significant higher number of somatic symptoms than non-practitioners and a higher use of rumination. Moreover, mindfulness experience was associated with the use of more adaptive emotion regulation strategies.ConclusionMindfulness meditation has been promoted as a practice enhancing well-being and helping to cope with the psychological impact of stressful events. However, in a distressing situation as COVID-19 pandemic, a limited experience in mindfulness practices might result in the development or endurance of somatic symptoms. Adequate training and a focus on mindful acceptance, may contribute to enhance the effectiveness of mindfulness practice.
The association between adverse pregnancy outcomes with genital Chlamydia Trachomatis infection among pre-pregnancy couples in Shenzhen, China: A cross-sectional study
Authors: Sun Si , Zhang Li , Wu Qiuhong , Tian Lishan , Ding Yi , Liu Lanlan , Ye Hailing , Li Bo , Luo Zhenzhou 
Published: December 2022

ObjectivesTo investigate the prevalence of adverse pregnancy outcomes (APOs) in women and the impact of pre-pregnancy couples' genital Chlamydia Trachomatis (GCT) infection and other infections on APOs.Study designData on genital infections were collected from the Free Pre-pregnancy Health Check (FPHC) in Shenzhen, China. Data on APOs were collected from a 1-year telephone follow-up of pregnancy status and subsequent pregnancy outcomes.MethodsAPO data were used to count adverse outcomes, and logistic regression was conducted to determine the association between APOs and GCT infection.ResultsFrom December 2018 to December 2019, among 4,429 couples who underwent FPHC; 1,925 were pregnant, and 1,816 couples were tracked for pregnancy outcomes, including 1,471 normal pregnancies and 345 (19.00%) APOs. The rest of 109 pregnant couples did not answer the phone or refused to answer the pregnancy outcome during the follow-up. Among APOs, the number of spontaneous abortions was 122 (35.36%), the number of macrosomia was 85 (24.64%), the number of low birth weight (LBW) &amp; preterm births (PTB) was 39 (11.30%), the number of LBW was 34 (9.86%), and the number of PTB was 31 (8.99%). The prevalence of GCT infection in females and males was 4.24% [95% Confidence Interval, (CI): 3.41–5.27%] and 3.58% (95% CI: 2.79–4.57%), respectively. More than half (52.69%, 49/93) of the couples were GCT-concordant. The prevalence of APOs in couples without GCT infection was 18.74% (332/1,772). The prevalence of APOs in female GCT-discordant was 32.14% (9/28), and the prevalence of APOs in male GCT-discordant was 25% (4/16). The prevalence of APOs in GCT-concordant was 12.24% (6/49). Multivariable analysis indicated that females 30–35 years old [adjusted Odds Ratio (aOR) = 1.08, 95% CI: 1.01–1.17] and over 35 years old (aOR = 1.16, 95% CI: 1.03–1.32) were more likely to experiencing APOs.ConclusionAlthough only women's age was found to be associated with APOs, the prevalence of APOs with GCT-discordant in couples, especially female GCT-discordant, was higher than in those without infection or who were GCT-concordant, suggesting that these groups, especially in older women, should be paid more attention to in follow-ups to improve reproductive health.
Institutional delivery and associated factors among women who gave birth in Benishangul Gumuz region, South West Ethiopia
Authors: Arega Temesgen , Mulatu Teshale , Alemayehu Afework , Mussa Ibsa , Dheresa Merga 
Published: December 2022

BackgroundMaternal mortality from pregnancy and childbirth remains a major public health problem. Increasing access to institutional delivery is one of the key strategies to reduce childbirth-related maternal mortality. Despite all the efforts, institutional deliveries in Ethiopia remain low. Understanding factors associated with institutional delivery is important to devise strategies to improve facility based child birth. Hence, this study assessed the prevalence of institutional delivery and associated factors to bridge the gap.MethodsA community-based cross-sectional study was employed from March-April 2020. Multi-stage sampling was employed to select 500 mothers who gave birth within the last 12 months in Mandura district, Benishangul Gumuz Region, Ethiopia. Data were collected using pre tested structured questionnaire through face-to-face interview. Logistic regression models were fitted to assess the predictors of institutional delivery. Adjusted Odds ratios with 95% CI was used to show associations and statistical significance was set at a p &lt; 0.05.ResultsThis study indicated that the prevalence of institutional delivery was 28.8% CI (25–33.3%). Having a positive attitude (AOR = 9.6,95%CI:2.5–35.9), attending antenatal care (ANC) at least once (AOR = 16.1,95%CI:9.6–22), attending ANC more than three times (AOR = 17.2, 95% CI:13.5–43.8), having good knowledge (AOR = 11.1, 95%CI: 2.7–45.4), and facing complications during pregnancy (AOR = 4.04, 95%CI: 1.0–16.0) were significantly associated with institutional delivery.ConclusionThe prevalence of institutional delivery in this study was low. Positive attitude toward institutional delivery, attending ANC, having good knowledge about institutional delivery, and facing complications during pregnancy were identified predictors of institutional delivery. Strategies with a focus on increasing ANC uptake, improving mothers' knowledge, and promoting institutional delivery at the community level are critical.
Perancangan Sistem Informasi Rekam Medis Menggunakan Teknologi RFID Pada Puskesmas Muara Bulian
Authors: Lesmana Andi , Sunoto Akwan , Hendrawan Hendrawan 
Published: December 2022

Puskesmas Muara Bulian merupakan salah satu puskemas yang ada di kabupaten Batang Hari yang sistem pengolahan data rekam medisnya masih dilakukan secara manual. Dengan sistem seperti ini pengolahan data Rekam Medis berjalan lambat, baik dalam pendataan identitas pasien, pendataan data kunjungan, pendataan antrian, pendataan diagnosa serta pendataan tindakan yang dilakukan terhadap pasien. Proses penyajian laporan rekam medis juga berjalan lambat karena catatan rekam medis mesti dicari satu persatu. Selain itu Ketika berobat pasien juga sering tidak membawa kartu berobat dikarena kartu berobat yang dalam bentuk media kertas rusak atau sobek, hal ini tentu membuat pihak puskesmas membutuhkan waktu membuat kartu baru serta mencari catatan rekam medis dari pasien. Karena itu dalam rangka memberikan layanan yang optimal kepada masyarakat maka perlu dibangun sistem informasi rekam medis pada Puskesmas Muara Bulian ini. Sistem informasi dibangun dengan menggunakan bahasa pemrograman PHP dan DBMS MySql dengan menggunakan Teknologi RFId serta pemodelan menggunakan diagram UML. Dengan adanya sistem informasi rekam medis ini pengolahan data bisa berjalan lebih baik dan pelayanan puskesmas kepada masyarakat bisa lebih optimal.
Sistem Pelayanan Akademik Terhadap Keluhan Mahasiswa Pada Perguruan Tinggi Untuk Mencegah Mahasiswa Berhenti Kuliah Dengan Metode Web Responsive Design
Authors: Hendri  , Johni Paul Karolus  
Published: December 2022

The current education industry in Indonesia continues to grow and competition is getting tougher so that more and more universities are competing to be able to provide better academic services to get students or prospective students. To be able to win the competition, universities must be able to provide maximum service quality. Good service will certainly make students feel comfortable and at home in the learning process at college so that it can reduce the number of students who stop studying, leave and drop out. Academic services as the core of business in universities must certainly be improved in order to increase the number of students who will enter the University. If the university does not know what the student's problems / obstacles are in the lecture process, it will certainly be difficult to find reasons why students drop out or why students leave. The purpose of this study is to create an academic service system for student complaints. It is hoped that the upper management of higher education can find out what problems / obstacles students are facing from the start so that they can prevent students from dropping out of college by providing correct solutions according to student needs.
Utilization of The Mobile Application of National Health Insurance (JKN) To Increase The Effectiveness of Services BPJS Insurance In Sibolga
Authors: Situmorang Benri 
Published: December 2022

Currently, the government has developed several mobile applications for the National Health Insurance (JKN) to facilitate services for patients. The development of some of these applications aims to help consumers and support patient-centered decisions in choosing which benefits to choose (Bundorf et al., 2019). The digital transformation of the Badan Penyelenggara Jaminan Sosial (BPJS) is to provide convenience for BPJS users or the public, such as paying BPJS contributions, changing membership data, knowing family participant data, etc (Kipo-Sunyehzi, 2021). The aims of this study is to determine the use of the national health insurance application (JKN) to increase the effectiveness of BPJS health services in the city of Sibolga. The type of research taken is descriptive research with a qualitative approach. This study took as many as four resource persons. While the data collection technique is using the technique of observation, interviews and documentation. The results showed that through the national health insurance (JKN) mobile application, all administrative services at the Sibolga City BPJS office for patients became more effective and efficient. This shows that the benefits of the JKN mobile application have proven to be very helpful in accessing BPJS health services.