bluuebunny/crossref_metadata_2025_split huggingface dataset:
Risk of future cardiovascular diseases in different years postpartum after hypertensive disorders of pregnancy: A systematic review and meta-analysis
Authors: Sukmanee Jarawee , Liabsuetrakul Tippawan 
Published: August 2022

Objective:
There are limited data on the optimal timing and frequency of postpartum follow-up visits after hypertensive disorders of pregnancy (HDP) for primary prevention and early detection of cardiovascular diseases (CVDs) in high-risk women. We aimed to evaluate the risk of cardiovascular outcomes later in life in women with prior HDP in different years postpartum and in preeclamptic women with severe features, or early onset of preeclampsia.

Methods:
We searched MEDLINE, Cochrane Library, Web of Science, and Scopus without language restriction for relevant articles published from inception to March 16, 2022. We included prospective and retrospective cohort studies assessing hypertension, ischemic heart disease, heart failure, venous thromboembolism, peripheral vascular disease, stroke, dementia, composite cardiovascular and/or cerebrovascular diseases, and mortality after 6 weeks postpartum, in women with prior HDP compared with controls. Two authors independently selected and appraised the studies. Article quality was independently assessed using the Newcastle-Ottawa Scale (NOS). Random-effect models were used for meta-analysis. Stratified analyses based on years postpartum, severity, and onset of preeclampsia were performed.

Results:
We included 59 studies for qualitative review, of which 56 were included in quantitative meta-analysis, involving 1,262,726 women with prior HDP and 14,711,054 controls. Women with prior HDP had increased risks of hypertension (relative risk [RR] 3.46, 95% confidence interval [CI]: 2.67–4.49), ischemic heart disease (RR 2.06, 95% CI: 1.38–3.08), and heart failure (RR 2.53, 95% CI: 1.28–5.00) later in life, compared with those with normotensive pregnancies. The risk of hypertension was highest during 5 years postpartum (RR 5.34, 95% CI: 2.74–10.39). Compared with normotensive pregnancies, the risk of future CVDs significantly increased in preeclamptic women.

Discussion:
A history of HDP is associated with approximately 2- to 4-fold increase in the risk of CVDs. Screening for CVDs and their risk factors in women with prior HDP since delivery, especially the first 5 years after delivery is suggested for early detection and appropriate management. Evidence on the risks of CVDs in preeclampsia with severe features and early onset of preeclampsia is limited due to having few studies and high heterogeneity.

Funding:
The Royal Golden Jubilee PhD Program–RGJ (PHD/0183/2561); Thailand Science Research and Innovation (TSRI) Research Career Development Grant–RSA (RSA6180009); Targeted Research Grants Program of the Faculty of Medicine, Prince of Songkla University, Thailand.

Registration:
CRD42020191550
Effects of fascia iliaca compartment block as an adjunctive management to parecoxib for pain control after total hip arthroplasty
Authors: Li Xiao-yan , Zhang Liang , Ding Yu-mei , Wang Cai-xia , Qiu Yi 
Published: August 2022

Background:
This retrospective study investigated the effects of fascia iliaca compartment block (FICB) as an adjunctive management to parecoxib for pain control after total hip arthroplasty (THA).

Methods:
A total of 72 patient records of THA were included in this retrospective study. All patients received parecoxib and were allocated to either the treatment group (n = 36) or the control group (n = 36). In addition, patients in the treatment group underwent FICB. The primary outcome was pain intensity measured using a resting and moving visual analog scales (VASs). The secondary outcomes were inflammatory factors (interleukin 6 and C-reactive protein) and occurrence rate of adverse events.

Results:
Patients in the treatment group had better outcomes in the resting VAS (12 hours, P < .01; 24 hours, P < .01; 36 hours, P = .01; 72 hours, P = .03), moving VAS (12 hours, P < .01; 24 hours, P < .01; 36 hours, P = .02; 72 hours, P = .02), serum interleukin 6 (P < .01), and C-reactive protein (P < .01) than those in the control group at different time points. In addition, there were no significant differences in the occurrence rate of adverse events.

Conclusion:
The findings of this study demonstrated that the effects of FICB as an adjunctive management to parecoxib are superior to those of parecoxib alone for pain control after THA.
CKAP2 overexpression correlates with worse overall survival in patients with lung adenocarcinoma
Authors: Zhang Sen , Li Na , Yang Yonghua , Li Yan , Lin Chenshi , Fu Guoquan , Cai Jun 
Published: August 2022

Background:
Adenocarcinoma is a non–small-cell lung cancer that is common cancer in both genders, and has poor clinical outcomes. We aimed to evaluate the role of cytoskeleton-associated protein 2 (CKAP2), its prognostic significance, and the relationship between CKAP2 expression and lung adenocarcinoma driver genes.

Methods:
The expression of CKAP2 was studied by immunohistochemical staining of specimens from 88 patients with lung adenocarcinoma. The correlation between clinicopathological features and CKAP2 expression was analyzed. Kaplan-Meier analysis and Cox proportional hazard models were used to examine the prognostic value of CKAP2 in terms of overall survival (OS). The correlation between epidermal growth factor receptor (EGFR) mutation, anaplastic lymphoma kinase (ALK) rearrangement, and CKAP2 expression was analyzed. All histological samples were detected by fluorescence in situ hybridization for EGFR mutations and ALK rearrangements.

Results:
Eighty-eight patients with positive CKAP2 expression were observed in this study. Patients with high levels of CKAP2 expression were associated with OS (P = .021). Multivariate Cox regression analysis disclosed that positive CKAP2 expression (P = .043) could independently predict unfavorable OS. In addition, CKAP2 expression was not associated with EGFR mutation (P = .219) and ALK rearrangement (P = .389) in lung adenocarcinoma patients.

Conclusion:
High expression of CKAP2 may serve as a marker of poor prognosis in lung adenocarcinoma.
Real-life use of Doravirine in treatment-experienced people living with HIV: A multicenter Italian study
Authors: Mazzitelli Maria , Antoni Melania Degli , Castelli Francesco , Ripamonti Diego , Zuglian Gianluca , Lapadula Giuseppe , Fabbiani Massimiliano , Ferraresi Alice , Putaggio Cristina , Cattelan Anna Maria , Quiros-Roldan Eugenia 
Published: August 2022

Use of doravirine (DOR), a new nonnucleoside reverse-transcriptase inhibitors recently approved for HIV treatment, is still unclear in clinical practice and real-life data are scarce.
We retrospectively investigated the rationale for switching people with HIV to DOR-containing/-based regimens in a real-life cohort. Among 132 patients (68.9% males, median age 56 years), the main reasons to start DOR were prevention of toxicities (39.4%) and dyslipidemia (18.2%). DOR was combined with integrase inhibitors in 40.9% cases, and in 25.7% of patients, DOR was prescribed without availability of a genotypic resistance test.
Twenty-four weeks after the switch to DOR-containing/-based regimens, no significant changes in CD4+ T-cell count, CD4/CD8 ratio, detectable HIV-RNA, serum creatinine levels, and body weight were detected. By contrast, a significant reduction in lipids (both cholesterol and triglycerides) was observed in 52 patients for whom a follow-up assessment was available (P = .008 and .01, respectively).
Our data confirmed that switching to DOR-containing/-based regimens may have a favorable impact on lipid profile and a neutral impact on weight gain. However, more data are needed to support its use in patients who do not have a genotypic test available or have an extensive nonnucleoside reverse-transcriptase inhibitors-associated resistance, as well as its use in a dual regimen, especially in combination with second-generation integrase inhibitors.
Intradural extramedullary capillary hemangioma with intramedullary component: A case series
Authors: Zhao Zhen , Zheng Jin , Zhou Yingchun 
Published: August 2022

Rationale:
Capillary hemangioma in the spinal cord is an exceedingly rare entity that is liable to be misdiagnosed. To summarize the clinical presentation, radiological characteristics, and pathological features of capillary hemangioma in the spinal cord and to share our experience for the diagnosis and treatment of intradural extramedullary capillary hemangioma.

Patient concerns:
Three patients underwent surgical treatment at our hospital between January 2020 and August 2020. All patients were male[median age at presentation: 57 years (range: 56–60)]. Two patients were experiencing pain and numbness in the lower back, and 1 patient was experiencing numbness and weakness in the left lower limb. The duration of symptoms ranged from 1 to 5 months.

Diagnosis:
All patients were diagnosed with spinal cord capillary hemangioma after treatment. All lesions were in an intradural extramedullary location and involved spinal cord components. Two patients had lesions in thoracic segments (T8, Th9-10), and 1 patient had a lesion in lumbar segment (L1).

Interventions:
All patients underwent microscopic laminectomy and complete resection of the extramedullary and intramedullary components of the spinal cord capillary hemangiomas.

Outcomes:
Postoperatively, all patients experienced transient numbness and pain in the lower limbs, which gradually decreased over time. None of the patients experienced bleeding, severe numbness or pain, or recurrence of symptoms at 3-month follow-up.

Conclusion:
Intradural extramedullary capillary hemangioma has unique morphological characteristics. Gross-total resection of the extramedullary and intramedullary components of spinal cord capillary hemangioma is recommended for patients with symptoms of spinal cord compression. Careful preoperative imaging and intraoperative decision-making may help avoid residual lesions or reoperation.
Correlations of thyroid autoantibodies with allergic diseases: A case-control study of 434 Chinese patients
Authors: Zhang Congcong , Hong Chengwei , Lian Xiaolan , Wen Liping , Xu Kun , Tian Zhuang , Si Wenjie , Li Yongning 
Published: August 2022

There is growing interest in the relationship between allergies and autoimmune diseases, although previous studies have yielded inconsistent results.
The thyroglobulin (Tg)/thyroid peroxidase antibody (TPOAb) group consisted of 217 patients with positive thyroglobulin antibody (TgAb) and/or TPOAb test results. Another set of 217 age- and sex-matched individuals with both TgAb- and TPOAb-negative results were selected as control group. History of allergic rhinitis (AR), chronic spontaneous urticaria (CSU), and/or atopic dermatitis (AD) was elicited before autoantibody detection. The association of thyroid autoantibodies with allergic diseases was assessed using univariate and multivariate logistic regression analysis, and the results were reported as odds ratios (ORs).
TgAb positivity (OR, 2.333) was identified as a risk factor for AR, AD, or CSU in Chinese patients, suggesting the involvement of thyroid autoantibodies in the pathogenesis of atopic reactions. Multivariate regression analysis also confirmed that the presence of TgAb (P = .004), rather than TPOAb (P = .468), had a significant impact on the occurrence of allergic disease.
Physicians should carefully monitor atopic symptoms in individuals with elevated TgAb or TPOAb levels to reduce the risk of allergic diseases, such as AR, AD, and CSU.
Serum levels of apolipoprotein A-I and E are associated with postoperative delirium: A post hoc analysis
Authors: Mietani Kazuhito , Hasegawa-Moriyama Maiko , Inoue Reo , Ogata Toru , Shimojo Nobutake , Kurano Makoto , Yatomi Yutaka , Uchida Kanji , Sumitani Masahiko 
Published: August 2022

Postoperative delirium is a common complication for elderly patients. Detection of phosphorylated neurofilament heavy subunit in the serum reflects axonal damage with postoperative delirium. Although it has been implicated that serum apolipoprotein levels might be associated with senile cognitive disorder, its role in the development of delirium has not been fully investigated. This study examined the association of apolipoproteins with delirium after surgery.
This was a post hoc analysis of 117 patients who participated in a prospective observational study of delirium in patients undergoing cancer surgery. Patients were clinically assessed for delirium within the first 5 days of surgery. Serum levels of apolipoprotein A-I, B, and E were measured on postoperative day 3.
Forty-one patients (35%) were clinically diagnosed with postoperative delirium. Serum levels of apolipoprotein A-I and B were increased in patients with delirium whereas those of apolipoprotein E were decreased. These changes in apolipoprotein A-I and E levels were associated with the presence of phosphorylated neurofilament heavy subunit in the serum, and were significantly associated with delirium (A-I: adjusted odds ratio [aOR], 6.238; 95% confidence interval [CI], 2.766–20.68; P < .0001; E: aOR, 0.253; 95% CI, 0.066–0.810; P = .0193). A combination of apolipoprotein A-I and E offers significant discrimination between delirium and nondelirium with high accuracy (area under the curve, 0.8899).
Serum apolipoprotein A-I and E levels were associated with delirium and the presence of phosphorylated neurofilament heavy subunit in serum. Therefore, apolipoproteins might be useful biomarkers of postoperative delirium.
Leisure-time physical activity and risk of depression: A dose-response meta-analysis of prospective cohort studies
Authors: Guo ZhiGuang , Li Rui , Lu Songtao 
Published: August 2022

Background:
There has never been a dose-response meta-analysis of the relationship between physical activity and the risk of depression. Hence, we aimed to explore the dose-response relationship between leisure-time physical activity (LTPA) and the risk of depression through a meta-analysis to provide a basis for the prevention of depression.

Methods:
PubMed and Web of Science databases were searched using a computer to collect prospective cohort studies on the relationship between LTPA and depression between January 1997 and July 2021. A dose-response meta-analysis was performed using the Stata 14 software to calculate the combined effect size relative risk (RR and 95% confidence interval CI).

Results:
Twelve cohort studies included 310,359 subjects who met the inclusion criteria. The categorical dose-response analysis results showed that the risk of incident depression was 27%, 17%, and 8% lower for the light, moderate, and highest dose LTPA participants, respectively (RR: 0.73, 95% CI: 0.64–0.82; RR: 0.83, 95% CI: 0.78–0.87; RR: 0.92, 95% CI: 0.86–0.99), compared with the lowest LTPA category. Continuous dose-response analysis showed a nonlinear relationship between LTPA and the risk of incident depression (P = .04). The risk of incident depression was reduced by 3% (RR: 0.97, 95% CI: 0.95–0.98) for every 5 MET-h/week increase in LTPA < 25 MET-h/week; when LTPA was higher than 25 MET-h/week, a 4% increase in the risk of depression for every 5 MET-h/week increase was observed (RR: 1.04, 95% CI: 1.02–1.05).

Conclusions:
There was a nonlinear relationship between LTPA and the risk of incident depression. Moderate and low doses of LTPA were protective factors in preventing the risk of incident depression, while high doses of LTPA may increase the risk of incident depression.
Trastuzumab-induced cardiotoxicity in early breast cancer over a 10-year period in Uruguay
Authors: Castillo Cecilia , Camejo Natalia , Etcheverria Cristian , Ferradaz Jessica , Ferreira Agustin , Fontan Analia , Gabin Ana Sofia , Herrera Guadalupe , Artagaveytia Nora , Parma Gabriel , Delgado Lucía 
Published: August 2022

This srudy aimed to estimate the prevalence of trastuzumab-induced cardiotoxicity in Uruguayan women diagnosed with human epidermal growth factor receptor 2 (HER2)-positive breast cancer over a 10-year period, who were treated under the financial coverage of the National Resources Fund (Fondo Nacional de Recursos).
This was an observational, descriptive study based on the analysis of an anonymized database of Uruguayan women diagnosed with HER2-positive breast cancer who received adjuvant trastuzumab treatment from to 2006 to 2016, provided by the Fondo Nacional de Recursos. Statistical analysis was performed using SPSS Statistics version 25, and variables were assessed using measures of central tendency, dispersion, contingency tables, and proportions. The chi-square test was used to analyze the association between the different variables.
The study included 1401 patients diagnosed with stage I to III HER2-positive breast cancer. The mean age at diagnosis was 52 years. The prevalence of cardiotoxicity was 20.3%. Most patients who discontinued treatment owing to cardiotoxicity eventually resumed treatment (92.6%). Moreover, the prevalence of cardiotoxicity was similar among patients who received regimens with and without anthracyclines. No association was observed between prior cardiovascular events or trastuzumab administration (concurrent vs sequential) and the development of cardiotoxicity.
In the present study, the prevalence of cardiotoxicity was similar to that reported nationally and internationally. Most patients did not develop cardiotoxicity, while the ones who developed it remained asymptomatic and cardiotoxicity was reversible.
Clinical characteristics and survival analysis of patients with limb epithelioid sarcoma
Authors: Lu Huanxin , Xu Qiang , Chen Xiaowei , Wang Zhan , He Fangming 
Published: August 2022

Limb epithelioid sarcoma (LES) is a rare and aggressive soft tissue sarcoma, which is scarcely reported. Therefore, the current study was performed to analyze the clinicopathologic features and risk factors of survival among patients with LES.
By using the Surveillance, Epidemiology, and End Results database, data were obtained regarding patients who were diagnosed with LES for the period between 2010 and 2016. We first analyzed overall survival (OS) and cancer-specific survival (CSS) by applying univariate Cox regression analysis. Then we performed multivariate analysis to confirm independent predictors of survival.
In total, we identified 475 patients with LES for survival analysis, of which 291 were males (61.3%) and 184 females (38.7%). The mean and median age at diagnosis were 38 and 36 years, respectively. The 5-year OS and CSS rates among Patients with LES were 65.4% and 69.5%, respectively. Gender, age, tumor stage, tumor size, and treatment type were significant predictors of OS on both univariate and multivariate analyses (P < .05). As for CSS, multivariable analysis revealed that age <60 years, localized stage, and tumor size <5 cm were significantly associated with increased survival (P < .05).
Predictors of improved survival for LES patients include gender, age, tumor stage, tumor size, and treatment type. Surgery only was recommended for treating LES patients. Future studies are warranted to determine effective treatment types for LES patients.
Suicide Via Multiple Shotgun Wounds
Authors: Giffen Mark A. , Blankenship Heath , Harrison William 
Published: August 2022

Abstract
Suicide via multiple gunshot wounds is an uncommonly encountered phenomenon, which is important to recognize in the forensic community. Suicide by multiple shotgun wounds is a fleeting rare entity with few previously reported cases in the literature. In a review of autopsies performed at our institution during a 20-year period from 2000 to 2020, only 4 prior cases of suicide by multiple gunshot wounds were identified with no previously recorded cases of suicide by multiple shotgun wounds. Here we describe the case of a 20-year-old man with a history of depression who was discovered deceased in his secured residence with shotgun wounds of the head, neck, and chest. Because of the presence of 3 shotgun wounds, coupled with concerning initial investigative findings, an autopsy was performed. We illustrate how careful examination of the wounds and thorough investigation can allow for reconstruction of a plausible self-inflicted wound scenario.
A Rare Cause of Shock in a Child Diagnosed by Point-of-Care Ultrasound
Authors: Statler James R. , Cohen Stephanie G. 
Published: August 2022

Abstract
A 3-year-old boy presented to the emergency department with vomiting and abdominal pain. Point-of-care ultrasound identified a sinus of Valsalva aneurysm. We describe a case where point-of-care ultrasound was used to evaluate a child who presented with nonspecific abdominal pain leading to the diagnosis of this rare cardiac condition and life-saving surgical treatment.
Chronic primary musculoskeletal pain: a new concept of nonstructural regional pain
Authors: Fitzcharles Mary-Ann , Cohen Steven P. , Clauw Daniel J. , Littlejohn Geoffrey , Usui Chie , Häuser Winfried 
Published: August 2022

Abstract
The concept that a regional musculoskeletal pain may occur in the absence of identifiable tissue abnormality may be puzzling. Previously these regional complaints were generally categorized as myofascial pain syndromes, or prior to the formalization of the nociplastic pain concept, as musculoskeletal pain with a neuropathic component, and treatments were anatomically focussed. Chronic primary musculoskeletal pain is now identified under the chronic primary pain stem category with the mechanistic descriptor of nociplastic pain. It is possible that many patients previously diagnosed with myofascial pain do in fact suffer from chronic primary musculoskeletal pain, requiring a paradigm shift in management towards more centrally directed treatment strategies. Many questions remain, including validation of the proposed examination techniques, prevalence, ideal treatment, and uptake and acceptance by the healthcare community. This new classification should be welcomed as an explanation for regional pain conditions that previously responded poorly to physically focussed treatments.