bluuebunny/crossref_metadata_2025_split huggingface dataset:
Synthesis, Biological Evaluation and In Silico Studies of Some 2‐Substituted Benzoxazole Derivatives as Potential Anticancer Agents to Breast Cancer
Authors: Kuzu Burak , Hepokur Ceylan , Alagoz Mehmet Abdullah , Burmaoglu Serdar , Algul Oztekin 
Published: January 2022

AbstractIn an attempt to develop potent and selective anticancer agents, some 5‐ or 6‐ and N‐substituted benzoxazol‐2‐carboxamide derivatives were designed, synthesized, and evaluated for their cyclooxygenase inhibitory, antioxidant, and anti‐proliferative activity against MCF‐7 and MDA‐MB‐231 cell lines. Among them 5‐OMe, N‐piperidine substituted (compound 30), 5‐OMe, N‐4‐methylpiperidine substituted (compound 31) and 5‐Cl, N‐piperidine substituted (compound 34) benzoxazole 2‐carboxamide compounds have a moderate inhibitory effect in COX‐1 and COX‐2 enzymes. Anti‐proliferative studies show that compound 30 (IC50=5.35 μM) and compound 31 (IC50=5.82 μM) have similar activity to reference drug 5‐FU (IC50=3.95 μM) on MCF‐7 cell but they have lower toxic effect for healthy WI‐38 cell line. For the MCF‐7 cell line, compounds 30 and 31 show approximately 1.5 times higher selectivity compared to the 5‐FU control. Among the synthesized compounds 30, 31, and 34 had the best anti‐proliferative effect and were used to perform flow cytometry and cell cycle analysis on MCF‐7 cell line. To predict the binding modes and pharmacokinetic parameters of all compounds, in silico studies were carried out. These compounds may shed light on cancer treatment and cancer research.
Synthesis and Characterization of Plant Derived Copper Oxide Nanoparticles and Their Application towards Oxygen Reduction Reaction
Authors: Prakash Jai , Shekhar Himanshu , Yadav Shyam R. , Sonkar Piyush K. , Kumar Narvadeshwar 
Published: January 2022

AbstractIn this work copper oxide nanoparticles (CuONPs) are prepared from precursor CuSO4.5H2O using plant leaves extract (PEE) of Eranthemum pulchellum(E. pulchellum).The synthesized CuONPs are characterized by ultraviolet visible (UV‐vis) spectroscopy, Fourier transform infrared (FTIR) spectroscopy, X‐ray diffraction (XRD) and transmission electron microscopy (TEM). CuONPs are distorted spherical in shape, with the sizes ranging from 5 to 17 nm. PEE and CuONPs are coated on glassy carbon (GC) electrode and abbreviated as GC/PEE and GC/CuONPs, respectively. The modified electrodes GC/PEE and GC/CuONPs are characterized with cyclic voltammetry (CV) techniques. The modified electrode GC/CuONPs exhibits good electrocatalytic activity for oxygen reduction reaction (ORR). GC/CuONPs also shows excellent operational stability up to 1000 CV cycles.
Development of Ca2+, Cr3+ Co‐Doped and Pr3+, Ca2+, Cr3+ Tri‐Doped β‐Ga2O3 Persistent Luminescence Nanoparticles with Enhanced Luminescence
Authors: Sun Xue‐Feng , Abdurahman Renagul , Chu Gang‐Hui , Yang Qian‐Ting , Yang Tong‐Sheng 
Published: January 2022

AbstractThe introduction of co‐dopants is one of the effective ways to improve the luminescence properties of the persistent luminescence nanoparticles (PLNPs). Herein, Cr3+, Ca2+ co‐doped and Cr3+, Ca2+, Pr3+ tri‐doped β‐Ga2O3 PLNPs with enhanced persistent luminescence were developed via the hydrothermal synthesis and subsequent calcinations, which improved the persistent luminescence of the β‐Ga2O3 PLNPs. The results showed that the prepared PLNPs had a long afterglow time of more than 8 days with a signal‐to‐noise ratio (SNR) of 272 and the Quantum yield (QY) up to 74.8 %, which was renewable by LED lamps and stored information under a high‐temperature environment. The synthesized β‐Ga2O3:Cr3+, Ca2+, Pr3+ PLNPs with long afterglow time showed great potentials in optical storage.
Supramolecular Assemblies of Sulfonatomethylated Calix[4]resorcinarenes with Aquated Sodium(I), Cesium(I), and Aluminum(III) Ions
Authors: Liu Jing L. , Zhang Pei Z. , Jia Ai Q. , Shi Hua T. , Zhang Qian F. 
Published: January 2022

AbstractInteractions of C‐iso‐butyl‐calix[4]resorcinarene (1) with sodium sulfite and formaldehyde solution gave a new water‐soluble sulfonatomethylated calix[4]resorcinarene (C4RS) 2 in a quantitative yield. Treatment of 2 with NaOH in a mixture of water, acetonitrile, and methanol afforded complex [Na4(C4RS‐4H)(CH3CN)(H2O)6]2⋅CH3OH (3). Reaction of 2 with NaOH aqueous solution, followed by addition of cesium chloride, led to isolation of complex Cs4Na[(C4RS)2‐5H)](H2O)2 (4). Cation exchange of aluminum nitrate hydrate with complex 3 afforded complex {Al3(H2O)5[(C4RS)2‐9H)]}2⋅(C2H5OH)2⋅(H2O)4 (5). The three new coordination complexes 3–5 were characterized by single crystal X‐ray diffraction analysis. Complexes 3 and 4 display a two‐dimensional bilayer structure through bridging of the sulfonate groups by sodium/cesium cations. The aluminum sulfonatomethylated calix[4]resorcinarene sheets in complex 5 are associated in a one‐dimensional bilayer arrangement and further connected by hydrogen bonds to form a two‐dimensional network.
Enantioselective Organocatalytic Michael Addition Reactions Catalyzed by Proline/Prolinol/Supported Proline based Organocatalysts: An Overview
Authors: Pasuparthy Sai Deepak , Maiti Barnali 
Published: January 2022

AbstractEver since the discovery of enantioselective organocatalytic Michael addition reactions, it has emerged as a significant path for synthesizing a variety of stereochemical products under mild conditions, also a prominent C−X (X=C, O, N, S) bond formation reaction in organic chemistry. Over time, substantial progress has been accomplished in diversity‐ and target‐ oriented asymmetric Michael addition reactions. This review provides a brief overview of the results, scope, and limitations of several influential strategies involving enantio‐selective Michael addition reactions promoted by mono‐functional proline/prolinol/supported‐proline‐based chiral organocatalysts. Furthermore, we also sincerely believe that the various synthetic strategies documented in this review will pave a pathway to improve the status of Michael addition reactions for synthesizing various drug molecules involving complex intermediates.
Construction of Laterally Asymmetric Heterojunctions with Sub‐Micrometer Resolution by Hierarchical Self‐Assembly of Polythiophene Nanofibers
Authors: Zheng Hongxian , Li Wenbin , Chen Yurong , Jiang Baichuan , Che Yu , Ou Cailing , Li Jun , Han Xiao , Liu Chuanhui , Zhang Lei 
Published: January 2022

AbstractPolymeric semiconductors are crucial candidates for the construction of next‐generation flexible and printable electronic devices. By virtue of the successful preparation of monodispersed colloidal solution in orthogonal solvent, poly(3‐hexylthiophene) (P3HT) nanofibers are developed into versatile building blocks for nanoelectronics and their compatibilities are verified with photolithographic lift‐off technology. Then, the joint efforts from both the bottom‐up hierarchical self‐assembly and top‐down self‐alignment technology have led to the realization of lateral asymmetric heterojunctions with resolution better than 1 µm. As a result, planar photovoltaic devices incorporating N,Nʹ‐dioctyl‐3,4,9,10‐perylenedicarboximide and P3HT supramolecular nanowires as active components are constructed with the cathode‐to‐anode distance being tuned from ≈0.1 to 1–2 µm. Based on such a novel device configuration, an interesting phenomenon of channel‐length‐dependent photovoltaic efficiency is observed for the first time, strongly suggesting the impact of near‐field light intensity on the performance of nanophotonic devices.
Novel FeNi‐Based Nanowires Network Catalyst Involving Hydrophilic Channel for Oxygen Evolution Reaction
Authors: Qiao Xianshu , Kang Hongjun , Li Yang , Cui Kai , Jia Xin , Wu Xiaohong , Qin Wei 
Published: January 2022

AbstractDeveloping novel, efficient, and low‐cost 3D FeNi‐based oxygen evolution reaction (OER) catalysts with the special hydrophilic channel is still a challenge for improving hydrogen production efficiency. Herein, a novel 3D ethoxy substituted FeNi oxalate (ENWs‐FeNi‐C2O4) nanowires network catalyst with hydrophilic channels is reported firstly, which shows an outstanding OER activity with a low overpotential (215 mV at 10 mA cm−2) and small Tafel slope (54.5 mV dec−1). OER catalytic mechanism indicates that the OH adsorption step and O2 bubble diffusion step of OER reaction process can be significantly improved due to the special hydrophilic channels, and the ethoxy as an interlayer ligand not only expands the interlayer distance of layered FeNi (oxy) hydroxide true active species but modulates its electronic structure, promoting the *OOH formation step, and thus exhibiting the outstanding OER performance. This work provides a novel idea for the preparation of novel and efficient OER electro‐catalysts with special 3D structures.
Metal Centers and Organic Ligands Determine Electrochemistry of Metal–Organic Frameworks
Authors: Li Caoling , Shen Jian , Wu Kangbing , Yang Nianjun 
Published: January 2022

AbstractThe properties and applications of metal‐organic frameworks (MOFs) can be tuned by their metal centers and organic ligands. To reveal experimentally and theoretically the influence of metal centers and ligands on electrochemical performance of MOFs, three MOFs with copper or zinc centers and organic ligands of 2‐methylimidazole (2MI) or 1,3,5‐benzenetricarboxylic acid (H3BTC) are synthesized and characterized in this study. 2D and porous Cu‐2MI exhibits a larger active area, faster electron transfer capability, and stronger adsorption capacity than bulk Cu‐BTC and dodecahedron Zn‐2MI. Density functional theory calculations of adsorption ability of three MOFs toward xanthine (XA), hypoxanthine (HXA), and malachite green (MG) prove that 2D Cu‐2MI has the strongest adsorption energies to three targets. Rotating disk electrode measurements reveal that 2D Cu‐2MI features the biggest intrinsic heterogeneous rate constant toward three analytes. On 2D Cu‐2MI sensitive and selective monitoring of XA, HXA, and MG is then achieved using differential pulse voltammetry. Their monitoring in real samples on 2D Cu‐2MI is accurate and comparable with that using high‐performance liquid chromatography. In summary, regulation of electrochemical sensing features of MOFs is realized through defining selected metal centers and organic ligands.
The Impact of Patient Characteristics on Diagnostic Test Performance
Authors: Kozlowski Hannah N. , Sindhwani Shrey , Chan Warren C. W. 
Published: January 2022

AbstractDiagnostic tests can detect diseases, monitor responses, and inform treatments. They are vital to the effective management of disease. There have been significant advances in the engineering of new diagnostic technologies. These technologies may forgo sample extraction, simplify readout, or automate processing. Many researchers design these diagnostics based on test performance in a limited sample subset. This approach ignores the intertwined relationship between patient characteristics and diagnostic test results. Yet, it is important to understand the clinical decision‐making workflow and how the disease manifests in order to optimally design diagnostic tests. This review article explores the three aspects of incorporating patient characteristics to maximize diagnostic performance. 1) Characterize patient populations using patient demographics, disease prevalence, and other unique features. 2) Use the characteristics of the patient population to establish design requirements. 3) Determine the best use case since each case has different performance and target requirements. In this framework the clinical, technological, and unmet needs of a patient population shape the diagnostics design requirements. Following these steps will lead to maximal diagnostic performance and poise new diagnostics for real world use.
Behavior of RC columns strengthened with UHPFRC jackets through grooving method under eccentric loading: A comparative evaluation of steel and synthetic macro fibers in UHPFRC
Authors: Eshaghi‐Milasi Saadat , Mostofinejad Davood , Saljoughian Alireza , Bahmani Hadi 
Published: January 2022

AbstractThis study aims to examine the behavior of reinforced concrete (RC) circular columns retrofitted with ultra‐high‐performance fiber‐reinforced concrete (UHPFRC) jackets and fiber‐reinforced polymer (FRP) wraps under concentric and eccentric loading. In the present study, for the first time, UHPFRC jackets containing synthetic macro fibers (barchip) were used. The results were then compared with those obtained by UHPFRC containing steel fibers. Moreover, to improve the effect of concrete jacketing on the column behavior under eccentric loading, the innovative interface treatment of the longitudinal grooving method (GM) was applied. For these purposes, 15 such circular columns, 120 mm in diameter and 500 mm in height, were subjected to load eccentricities of 0, 30, and 60 mm. Thus, six columns were retrofitted with UHPFRC jackets 15 mm in thickness that included both steel and synthetic macro fibers (barchip) while another six were strengthened with UHPFRC jackets and intermittent glass FRP (GFRP) warps. The experimental results revealed that load‐carrying capacity raised with the increase of the load eccentricity, as evidenced by enhancements of 283%, 303%, and 401% in the loading capacity of the specimens strengthened with UHPFRC jackets containing both GFRP warps and steel fibers for eccentricities of zero, 30, and 60 mm, respectively, relative to those of the control. In addition, enhancements of 198% and 530% were recorded respectively for ductility and energy dissipation under a loading eccentricity of zero mm in specimens retrofitted with UHPFRC jackets including steel fiber and GFRP warps when compared with the same parameters in the corresponding control specimens. Finally, a previous theoretical model was adopted to derive the axial loading‐bending moment (P–M) interaction diagrams whereby the results of the present study were satisfactorily verified.
Inhibition of ALKBH5‐mediated m6A modification of PPARG mRNA alleviates H/R‐induced oxidative stress and apoptosis in placenta trophoblast
Authors: Guo Yongping , Song Wenxia , Yang Yali 
Published: January 2022

AbstractThe alpha‐ketoglutarate‐dependent (ALKB) homolog 5 (ALKBH5), an m6A demethylase, has been reported to be involved in the pathogenesis of preeclampsia (PE), but the exact mechanism requires further investigation. RT‐qPCR or Western blotting were used to determine ALKBH5 and peroxisome proliferator‐activated receptor gamma (PPARG) expression in placentas from PE patients and normal volunteers, as well as in HTR‐8/SVneo cells treated with hypoxia/reoxygenation (H/R). Our results showed that the expression of ALKBH5 was significantly upregulated and PPARG was downregulated in preeclamptic placentas and H/R‐treated cells. ALKBH5 interference reduced m6A levels of PPARG mRNA, and increased PPARG mRNA stability and promoted PPARG translation level. In addition, ALKBH5 silencing increased the cell proliferation, migration, and vimentin protein level, and inhibited cell apoptosis, oxidative stress, and protein levels of endoglin (ENG) and E‐cadherin in H/R‐treated cells, whereas PPARG interference reversed these effects. Furthermore, PPARG repressed the H3K9me2 levels at activated leukocyte cell adhesion molecule (ALCAM) promoter region by increasing the expression and activity of lysine demethylase 3B (KDM3B). ALCAM inhibition reversed the effects of PPARG overexpression on H/R‐treated cell functions. PKF115‐584 suppressed the effects of ALKBH5 interference on the behaviors of H/R‐treated cells. Finally, inhibition of ALKBH5 alleviates PE‐like features in pregnant mice. Inhibition of ALKBH5 promotes KDM3B‐mediated ALCAM demethylation by facilitating PPARG mRNA m6A modification, and further activates the Wnt/β‐catenin pathway, and in turn alleviates PE progression.
Upregulation of FAM129B protects cardiomyocytes from hypoxia/reoxygenation‐induced injury by inhibiting apoptosis, oxidative stress, and inflammatory response via enhancing Nrf2/ARE activation
Authors: Zeng Guangwei , Lian Cheng , Li Wei , An Huixian , Han Yang , Fang Dong , Zheng Qiangsun 
Published: January 2022

AbstractFamily with sequence similarity 129, member B (FAM129B) has been identified as a novel cytoprotective protein that facilitates the survival of detrimentally stimulated cells. However, whether FAM129B is involved in regulating cardiomyocyte survival after myocardial ischemia–reperfusion injury is unknown. The goal of this work was to evaluate the potential role of FAM129B in regulating hypoxia/reoxygenation (H/R)‐induced cardiomyocyte injury in vitro. We demonstrated that exposure to H/R markedly downregulated the expression of FAM129B in cardiomyocytes. Functional experiments revealed that the upregulation of FAM129B improved H/R‐exposed cardiomyocyte viability, and ameliorated H/R‐induced cardiomyocyte apoptosis, the generation of reactive oxygen species (ROS), and pro‐inflammatory cytokine release. The upregulation of FAM129B significantly increased the nuclear expression of nuclear factor‐erythroid 2‐related factor 2 (Nrf2), and reinforced Nrf2/antioxidant response element (ARE) activation in H/R‐exposed cardiomyocytes. Moreover, FAM129B modulates Nrf2/ARE signaling in a Kelchlike ECH‐associated protein 1‐dependent manner. Notably, the inhibition of Nrf2 significantly blocked FAM129B‐overexpression‐induced cardioprotective effects in H/R‐exposed cardiomyocytes. In summary, the findings of our work demonstrate that the upregulation of FAM129B ameliorates H/R‐induced cardiomyocyte injury via enhancing Nrf2/ARE activation. Thus, our study indicates that FAM129B may play a role in myocardial ischemia–reperfusion injury and has the potential to be used as a cardioprotective target.
Salt stress responses and SNP‐based phylogenetic analysis of Thai rice cultivars
Authors: Habila Susinya , Khunpolwattana Nopphakhun , Chantarachot Thanin , Buaboocha Teerapong , Comai Luca , Chadchawan Supachitra , Pongpanich Monnat 
Published: January 2022

AbstractGenetic diversity is important for developing salt‐tolerant rice (Oryza sativa L.) cultivars. Certain Thai rice accessions display salt tolerance at the adult or reproductive stage, but their response to salinity at the seedling stage is unknown. In this study, a total of 10 rice cultivars/line, including eight Thai cultivars and standard salt‐tolerant cultivar and susceptible line, were screened using a hydroponic system to identify salt‐tolerant genotypes at the seedling stage. Different morphophysiological indicators were used to classify tolerant and susceptible genotypes. Phylogenetic analyses were performed to determine the evolutionary relationships between the cultivars. Results showed that ‘Lai Mahk’, ‘Jao Khao’, ‘Luang Pratahn’, and ‘Ma Gawk’ exhibited salt stress tolerance comparable with the standard salt‐tolerance check ‘Pokkali’. Whole‐exome single‐nucleotide polymorphism (SNP)‐based phylogenetic analysis showed that the Thai rice cultivars were monophyletic and distantly related to Pokkali and IR29. Lai Mahk and Luang Pratahn were found closely related when using the whole‐exome SNPs for the analysis. This is also the case for the analysis of SNPs from 164 salt‐tolerance genes and transcription regulatory genes. The tolerant cultivars shared the same haplotype for 16 genes. Overall, the findings of this study identified four salt‐stress‐tolerant Thai rice cultivars, which could be used in rice breeding programs for salinity tolerance.
Copper(I) Complexes with Thioether‐Functionalized Silylamido Ligands
Authors: Liebing Phil , Merzweiler Kurt 
Published: January 2022

AbstractThe thioether‐functionalized aminosilanes Me2Si(NH‐C6H4‐2‐SR)2 (R=Ph, Me) were lithiated with n‐BuLi and subsequently allowed to react with CuCl in the presence of PMe3. In the case of Me2Si(NH‐C6H4‐2‐SPh)2, the dinuclear complex [Cu2{Me2Si(NC6H4‐2‐SPh)2}(PMe3)2] was isolated. In [Cu2{Me2Si(NC6H4‐2‐SPh)2}(PMe3)2] the copper atoms adopt a distorted trigonal‐planar coordination (Cu−N: 191.2(2) pm, Cu−P: 216.3(1) pm, Cu−S: 244.4(1) pm). The reaction of Li2Me2Si(N‐C6H4‐2‐SMe)2 with CuCl in the presence of PMe3 led to rearrangement processes from which the ionic cluster compound [Cu(PMe3)4][Cu5{Me2Si(N‐C6H4‐2‐S)(N‐C6H4‐2‐S−Me)}2(PMe3)2] was isolated in low yield.
Evaporated Responsibility: The Collapse of the West Gate Bridge in Melbourne on 15 October 1970
Authors: Seibel Wolfgang 
Published: January 2022

AbstractOn 15 October 1970, at 11:50AM, part of the West Gate Bridge in Melbourne, span 10-11 of 367 feet length, disintegrated and triggered the collapse of the bridge. Thirty-five men were killed in the disaster. The bridge was still under construction, all those killed were workers or engineers employed on the construction site. The investigation of a Royal Commission revealed a mismatch between an ambitious structural design of the bridge plus an unconventional method of erection and a fragmented, conflict-ridden construction management whose detrimental effects remained unchecked by public authorities. Regulatory powers and enforcement competence had been delegated to a QUANGO—a quasi-non-governmental organization—which diluted responsibility structures and decisively weakened the coordination and control capacity of the agency.
Conclusion: Strategic Learning and Situational High Reliability
Authors: Seibel Wolfgang 
Published: January 2022

AbstractPublic authorities are not high reliability organizations per se but they need to act as one as soon as safety issues are at stake. When it comes to construction and public infrastructure, however, responsibility for human safety may compete with the perceived necessity to respond to quests for accelerated licensing, fostering the local economy and general urban development, cooperative relations with contractors and consultants, compromises in local politics and similar types of legitimate expectations of clientele and the general public. Strategic learning for the sake of sustainable prevention requires to realize the responsiveness versus responsibility trade-off in the first place and to acknowledge the consequences for personal conduct in office under specific situational conditions. In the essence, it is about the strength and strengthening of professional and institutional integrity for the sake of human safety as an integral part of good governance and mindful public management.
The Virginia Company and the Foundations of Religious Governance in English Commercial Expansion
Authors: Smith Haig Z. 
Published: January 2022

AbstractThis chapter traces the use of religious governance in England’s early attempts to colonise Virginia between 1606 and 1624. It assesses how, in the initial steps to establish English authority abroad, religious governance was influenced by the political and governmental characters of successive company leaders such as Thomas Dale, Thomas Gates and John Smith. This explains why the Virginia Company embraced multiple forms of religious governance that would later be used as separate and distinct models of governance by successive companies. The Virginia Company experimented with religious governance to secure their control over English personnel abroad. Moreover, it became an instrumental tool in the companies’ attempts to expand their jurisdictional authority over Native American leaders, such as Powhatan, Pocahontas and her uncle Uttamatomakkin. By doing this company leaders hoped to establish governmental control over Native American peoples, and traditions, such as those Smith writes about in Generall Histoirie of Virginia, traditionally considered beyond the bounds of English governance. Finally, it examines how the experiences and memories of religious governance in the Virginia Company provided the groundwork for future forms of corporate religious governance to evolve.