bluuebunny/crossref_metadata_2025_split huggingface dataset:
Microperimetry to predict disease progression in eyes at high risk of age‐related macular degeneration disease: The PREVISION study
Authors: Kodjikian Laurent , Creuzot‐Garcher Catherine , Korobelnik Jean‐François , Tadayoni Ramin , Delafoy Ivan , Leal Cécilia , Bernard Lorraine , Decullier Evelyne , Huot Laure , Mathis Thibaud 
Published: September 2022

AbstractPurposeThe aim of the present study was to determine whether microperimetric parameters could predict the progression of an eye at high risk of age‐related macular degeneration (AMD) at 24 months.MethodsWe conducted a multicentric prospective non‐comparative open‐label study including patients with one eye in stage 4 of the Age‐Related Eye Disease Study Group (AREDS) classification, and the other eye in AREDS stage 3 (study eye). A microperimetry examination (MAIA™, CenterVue, Padova, Italy) was performed at baseline and every 6 months during the 2‐year follow‐up. At the end of the follow‐up, each study eye was classified as ‘progressive’ (i.e. AREDS stage 4) or ‘non‐progressive’ (i.e. AREDS stage 3).ResultsA total of 147 patients were analysed, of which 30.6% progressed from AREDS stage 3 to stage 4. The microperimetry criterion ‘mean retinal sensitivity’ was significantly different at baseline between non‐progressive and progressive eyes (p = 0.022), with lower values for the latter. With a threshold for mean retinal sensitivity set at 24.7 dB, diagnostic sensitivity was 80% [95%CI (65.4–90.4)], specificity was 30.4% [95%CI (21.7–40.3)], positive predictive value was 33.6% [95%CI (24.8–43.4)], and negative predictive value was 77.5% [95%CI (61.5–89.2)]. In the multivariate analysis including microperimetric parameters and other routine ophthalmologic examinations, mean retinal sensitivity was the only predictive parameter statistically associated with progression (p = 0.0004).ConclusionsOur findings are encouraging as regards the use of microperimetry, and mean retinal sensitivity value in particular, to predict the 2‐year risk of progression to AREDS stage 4 eye.
Discussion on “A Formal Causal Interpretation of the Case-Crossover Design” by Zach Shahn, Miguel A. Hernán, and James M. Robins
Authors: Lumley Thomas 
Published: September 2022

Abstract
It has always been clear that the case-crossover design works, for some definition of “works,” but some of the details have been surprisingly elusive, and it is good to see more of them nailed down by Shahn et al. My interest in case-crossover analyses has mostly been in the context of air pollution epidemiology mentioned at the end of the paper. The air pollution setting is distinctive for several reasons: as the exposure variable is plausibly exogenous, it is possible to use control times after the case time, the effects of interest are quite small, and the same measured exposure series is shared over many—perhaps all—of the cohort.
Integrative epigenomics in chronic lymphocytic leukaemia: Biological insights and clinical applications
Authors: Kulis Marta , Martin‐Subero Jose Ignacio 
Published: September 2022

SummaryChronic lymphocytic leukaemia (CLL) is not only characterised by driver genetic alterations but by extensive epigenetic changes. Over the last decade, epigenomic studies have described the DNA methylome, chromatin accessibility, histone modifications and the three‐dimensional (3D) genome architecture of CLL. Beyond its regulatory role, the DNA methylome contains imprints of the cellular origin and proliferative history of CLL cells. These two aspects are strong independent prognostic factors. Integrative analyses of chromatin marks have uncovered novel regulatory elements and altered transcription factor networks as non‐genetic means mediating gene deregulation in CLL. Additionally, CLL cells display a disease‐specific pattern of 3D genome interactions. From the technological perspective, we are currently witnessing a transition from bulk omics to single‐cell analyses. This review aims at summarising the major findings from the epigenomics field as well as providing a prospect of the present and future of single‐cell analyses in CLL.
Pathological complete remission of relapsed tumor by photo‐activating antibody–mimetic drug conjugate treatment
Authors: Kaneko Yudai , Yamatsugu Kenzo , Yamashita Takefumi , Takahashi Kazuki , Tanaka Toshiya , Aki Sho , Tatsumi Toshifumi , Kawamura Takeshi , Miura Mai , Ishii Masazumi , Ohkubo Kei , Osawa Tsuyoshi , Kodama Tatsuhiko , Ishikawa Shumpei , Tsukagoshi Masanobu , Chansler Michael , Sugiyama Akira , Kanai Motomu , Katoh Hiroto 
Published: September 2022

AbstractAntibody–mimetic drug conjugate is a novel noncovalent conjugate consisting of an antibody‐mimetic recognizing a target molecule on the cancer cell surface and low‐molecular‐weight payloads that kill the cancer cells. In this study, the efficacy of a photo‐activating antibody–mimetic drug conjugate targeting HER2‐expressing tumors was evaluated in mice, by using the affibody that recognize HER2 (ZHER2:342) as a target molecule and an axially substituted silicon phthalocyanine (a novel potent photo‐activating compound) as a payload. The first treatment with the photo‐activating antibody–mimetic drug conjugates reduced the size of all HER2‐expressing KPL‐4 xenograft tumors macroscopically. However, during the observation period, relapsed tumors gradually appeared in approximately 50% of the animals. To evaluate the efficacy of repeated antibody–mimetic drug conjugate treatment, animals with relapsed tumors were treated again with the same regimen. After the second observation period, the mouse tissues were examined histopathologically. Unexpectedly, all relapsed tumors were eradicated, and all animals were diagnosed with pathological complete remission. After the second treatment, skin wounds healed rapidly, and no significant side effects were observed in other organs, except for occasional microscopic granulomatous tissues beneath the serosa of the liver in a few mice. Repeated treatments seemed to be well tolerated. These results indicate the promising efficacy of the repeated photo‐activating antibody–mimetic drug conjugate treatment against HER2‐expressing tumors.
Benchmark performance of anodized vs. sandblasted implant surfaces in an acute dehiscence type defect animal model
Authors: Shahdad Shakeel , Bosshardt Dieter , Patel Mital , Razaghi Nahal , Patankar Anuya , Roccuzzo Mario 
Published: September 2022

AbstractObjectivesCrestal bone formation represents a crucial aspect of the esthetic and biological success of dental implants. This controlled preclinical study analyzed the effect of implant surface and implant geometry on de novo crestal bone formation and osseointegration.Materials and methodsHistological and histomorphometrical analysis was performed to compare three implant groups, that is, (1) a novel, commercially available, gradient anodized implant, (2) a custom‐made geometric replica of implant “1,” displaying a superhydrophilic micro‐rough large‐grit sandblasted and acid‐etched surface, and (3) a commercially available implant, having the same surface as “2” but a different implant geometry. The study applied a standardized buccal acute‐type dehiscence model in minipigs with observation periods of 2 and 8 weeks of healing.ResultsThe amount of newly formed crestal bone (BATA) around control groups (2) and (3) was significantly increased when compared to the test group (1) at the 8 weeks of healing time point. Similar results were obtained for all parameters related to osseointegration and direct bone apposition, to the implant surface (dBIC, VBC, and fBIC), demonstrating superior osseointegration of the moderately rough, compared to the gradient anodized functionalization. After 2 weeks, the osseointegration (nBIC) was found to be influenced by implant geometry with group (3) outperforming groups (1) and (2) on this parameter. At 8 weeks, nBIC was significantly higher for groups (2) and (3) compared to (1).ConclusionsThe extent (BATA) of de novo crestal bone formation in the acute‐type dehiscence defects was primarily influenced by implant surface characteristics and their ability to promote osseointegration and direct bone apposition. Osseointegration (nBIC) of the apical part was found to be influenced by a combination of surface characteristics and implant geometry. For early healing, implant geometry may have a more pronounced effect on facilitating osseointegration, relative to the specific surface characteristics.
Liberalism's distinctive policy for governing Muslim populations: Human rights, religious reform, and counter‐terrorism from the colonial era until the present
Authors: Nakissa Aria 
Published: September 2022

AbstractDuring the colonial era, liberal Western states established vast empires which came to encompass almost all of the world's Muslims. Western states worked out specific methods for governing Muslims, which were often referred to as “Muslim policy”. Recent scholarship on Muslim policy exhibits several key trends. One is expansion of geographical scope, leading scholars to produce more comprehensive global accounts of Muslim policy. Another trend is expansion of temporal scope, leading scholars to systematically link colonial Muslim policy with the governance of Muslims in the post‐colonial era. A final trend is the reevaluation of liberal governance. Accordingly, scholars argue that, contrary to conventional assumptions, liberal ideology allows for ‐ or even encourages ‐ imperialism, authoritarianism, ethnocentrism, and racism. The present article makes several new contributions. It provides a synthesis of recent studies on Muslim policy ‐ giving special attention to the key trends mentioned above. Moreover, the article proposes a novel way of conceptualizing Muslim policy. It is argued that Muslim policy centers on three overlapping projects: (1) a “human rights” project (2) a “religious reform” project and (3) a security project akin to what is now known as “counter‐terrorism”. Finally, the article argues that liberals created Muslim policy in the colonial era, and continue to champion it in the post‐colonial era. As such, it may be regarded as a distinctive long‐standing liberal policy for governing Muslim populations.
Residence after retirement: A review and bibliometric analysis
Authors: Wong Wong Ming , Long Hai , Wang Yifan , Su Wunhong 
Published: September 2022

AbstractThis study reviews the literature on the residence after retirement via Systematic Literature Network Analysis, which consists of the systematic literature review and bibliometric network analysis. There are three research questions, including (1) what the most recent studies are on the residence after retirement, (2) Who the most significant authors, documents, and sources are in residence after retirement, and (3) whether the extant research structure could guide the future agenda for the residence after retirement. Based on the systematic literature review, this study extracts 50 publications from the Scopus database by keyword, document type, source type, publication period, language, and subject area relevant to the residence after retirement. This study analyzes data employing Nvivo, VOSviewer, and SciMAX. The clusters of authors, countries, keywords, documents, and sources linked with relevant studies on the residence after retirement are according to the co‐authorship (1) author, (2) country/territory, (3) keyword, and (4) document. Skitmore, M., Xia, B., Buys, I., Hu, X., Hu, Y., and Chen, Q. who the most influential authors are in residence after retirement. The themes of aging, continuing care retirement community, retirement village, and their associated keywords contribute to future research on the residence after retirement.
Effects of acidification and sterilisation on the quality of channel catfish (Ietalurus punctatus) fillets
Authors: Yu Peipei , Zhang Zhiyun , Tang Xiaohang , Yu Dawei , Jiang Qixing , Gao Pei , Yang Fang 
Published: September 2022

SummaryThis study aims to investigate the effects of acidification and sterilisation on the quality of channel catfish, based on the texture, colour, physical and chemical properties, protein composition and water migration of channel catfish fillets. The results showed that the hardness, chewiness and colour of acidified and sterilised (AS) groups were significantly better than unacidified and sterilised (NAS) groups. The content of TCA soluble peptide in NAS was significantly higher than AS groups, indicating that high‐temperature sterilisation induced more protein degradation. Electrophoresis analysis also showed that the protein bands in the unacidified and sterilised (NAS) groups weakened or disappeared. There was no significant difference in the fat oxidation index of peroxide value and thiobarbituric acid value indicating that little effect on oxidation was induced by acidification and sterilisation. After sterilisation, the water transferred from immobilised water to free water, and the weight loss rate of acidified non‐sterilised (ANS) groups was significantly higher than AS. On the whole, acidified channel catfish could be sterilised at a lower temperature, thus having better texture, colour and lower weight loss rate. The sterilisation temperature of 91–95 °C was recommended to maintain a better quality of ready‐to‐eat acidified fish fillets.
Utilisation of watermelon, pineapple and banana fruit peels as prebiotics and their effect on growth of probiotic
Authors: Akter Beauty , Salleh Rabeta Mohd , Bakar Mohamad Hafizi Abu , Shun Tan Joo , Hoong Cheng Lai 
Published: September 2022

SummaryThis study aims to evaluate the prebiotic potential of selected fruit peels (watermelon, pineapple and banana) by studying their effects on growth of probiotic organisms as indicated by viable counts. The effect on probiotic growth was examined using different strains, namely Lactobacillus rhamnosus, L. plantarum and Bifidobacterium bifidum. The growth for L. plantarum and L. rhamnosus in pineapple peel extract (PPE) showed the maximum value of 8.27 and 7.53 log CFU/mL respectively, after 24 h incubation. The study also revealed that PPE contained the highest amounts of indigestible polysaccharides 351.13 mg/g as compared to other peels. The major reducing sugar consisted of glucose and fructose with a total amount of 442.75, 326.05 and 354.14 mg/g in dried peel extract from pineapple, watermelon and banana respectively. Pineapple and banana peel extract exhibited maximum hydrolysis of 9.21% and 8.74% and 32.95% and 30.63% when treated with gastric juice and α‐amylase. This investigation demonstrated that watermelon, pineapple and banana peel extract could be effectively used as prebiotics to improve the growth of beneficial microbes.
Evaluation of mixtures of maltodextrin and gum Arabic for the encapsulation of Andean blueberry (Vaccinium meridionale) juice by freeze–drying
Authors: Estupiñan‐Amaya Mauren , Fuenmayor Carlos Alberto , López‐Córdoba Alex 
Published: September 2022

SummaryAndean blueberry fruit is considered a source of bioactive compounds. However, its industrial applications as an ingredient are limited due to its low stability. In this work, Andean blueberry juice powders were obtained via freeze–drying. The effects of maltodextrin (MD) and gum Arabic (GA) as encapsulating agents were evaluated on the morphological, physicochemical, and rheological quality of the products, as well as in terms of the recovery of phenolic compounds. All the freeze–dried powders featured typical macroscopic and microscopic morphology, low moisture content (<5%) and water activity (aw < 0.3), high water solubility (>91%) and good flowability. The encapsulation with MD overall favoured higher water activity, solubility and flowability, and a significant increase of total phenolics recovery in the juice powders, compared with GA or GA:MD mixtures. The results showed that encapsulation by freeze–drying enables the production of Andean blueberry juice powders with suitable technological characteristics and potential as bioactive ingredients.
Concept analysis of recovery from substance use
Authors: Brophy Hailie , Dyson Michele , Katherine Rittenbach (Kay) 
Published: September 2022

AbstractIn this paper, we provide an analysis of the concept of recovery from substance use. We performed a literature search in CINAHL Plus, PsycINFO, MEDLINE, and Embase using key terms that focused on the concept of recovery from substance use. We also conducted a grey literature search and included select resources. Inclusive years for the search ranged from January 1, 2000 to March 10, 2022. Records were screened for eligibility by two independent reviewers; data were extracted by one reviewer and confirmed by a second. A total of 22 literature sources were included. Identified core attributes of recovery include: (i) recovery as a process, (ii) recovery as more than managing substance use, (iii) recovery as life improvements, and (iv) recovery as a person‐centred, individual concept. Antecedents, consequences, and empirical referents are identified, and model and contrary cases are presented. We propose the following definition for recovery: Recovery from substance use is defined by the affected individual, who sets goals and objectives for life improvements that include managing their substance use, but this is not the sole focus. Recovery is a person‐centred, individualized process that can be measured by referents that suit the individual's own goals and objectives. What may constitute “recovery” and “recovered” requires definition by each individual.
Simultaneous inference for linear mixed model parameters with an application to small area estimation
Authors: Reluga Katarzyna , Lombardía María‐José , Sperlich Stefan 
Published: September 2022

SummaryOver the past decades, linear mixed models have attracted considerable attention in various fields of applied statistics. They are popular whenever clustered, hierarchical or longitudinal data are investigated. Nonetheless, statistical tools for valid simultaneous inference for mixed parameters are rare. This is surprising because one often faces inferential problems beyond the pointwise examination of fixed or mixed parameters. For example, there is an interest in a comparative analysis of cluster‐level parameters or subject‐specific estimates in studies with repeated measurements. We discuss methods for simultaneous inference assuming a linear mixed model. Specifically, we develop simultaneous prediction intervals as well as multiple testing procedures for mixed parameters. They are useful for joint considerations or comparisons of cluster‐level parameters. We employ a consistent bootstrap approximation of the distribution of max‐type statistic to construct our tools. The numerical performance of the developed methodology is studied in simulation experiments and illustrated in a data example on household incomes in small areas.
Microstructure characterization of high‐pressure induced texture in fully densified zirconium diboride ceramics
Authors: Li Yulin , Zou Ji , Zhu Qiqi , Guo Weiming , Wang Weimin , Ji Wei , Fu Zhengyi 
Published: September 2022

AbstractFully dense oriented monolithic zirconium diboride (ZrB2) ceramics with <0001> fiber texture were fabricated using high‐pressure spark plasma sintering. The <0001> fiber texture is proposed to be triggered by grain rotation, as (0001) <> basal slip of ZrB2 was activated during sintering. The high temperature, uniaxial high pressure, and uniform starting particles play a vital role in the texture formation of ZrB2 ceramics. The result provides visible evidence for the occurrence of plastic deformation during high‐pressure‐assisted sintering.
Postpartum depression, social support and maternal self‐efficacy between adolescent and adult mothers during the COVID‐19 pandemic: A comparative cross‐sectional study
Authors: Sangsawang Nucharee , Sangsawang Bussara 
Published: September 2022

AbstractAimsTo determine the rate and level of postpartum depression (PPD), as well as to examine and compare PPD, social support and maternal self‐efficacy between adolescent and adult mothers at 8 weeks postpartum during the COVID‐19 pandemic.BackgroundPolicy measures to reduce the rapid spread of COVID‐19 have disrupted many aspects of life and decreased social connections, which negatively impacts psychological well‐being of the general population. However, studies focused on the impact of COVID‐19 on mental health and maternal self‐efficacy in postpartum mothers, particularly adolescent mothers, are limited.DesignA comparative cross‐sectional study was carried out following the STROBE guidelines.MethodsAn online questionnaire was administered from February to March 2021. Data were collected by the Edinburgh Postnatal Depression Scale (EPDS), the Postpartum Support Questionnaire (PSQ) and the Parenting Sense of Competence (PSOC) at 8 weeks postpartum. One‐way MANOVA was used to analyse the data.ResultsData from 63 adolescent mothers and 63 adult mothers were analysed. There were significant correlations between PPD, social support and maternal self‐efficacy of the COVID‐19 pandemic. Both adolescent and adult mothers had significantly negative impacts from the pandemic on mental health, social support and maternal self‐efficacy. However, the adolescent mothers had higher rates of depressive symptoms (36.5% and 23.8%, respectively) as well as lower PSQ score (121.25 and 130.52, respectively) and PSOC scores (62.54 and 70.94, respectively) compared with adult mothers in the first 8 weeks postpartum during the pandemic.ConclusionAdolescent mothers had a significantly higher rate of depressive symptoms and significantly lower social support and maternal self‐efficacy scores compared to adult mothers at 8 weeks postpartum during the COVID‐19 pandemic.ImpactMidwives or nurses should emphasize the negative mental health impacts during the COVID‐19 situation and routinely screen for depressive symptoms, especially in adolescent mothers, which could help identify the at‐risk mothers for developing PPD.Patient or public contributionNeither patients nor the public were directly involved in the study.
Adolescents with anorexia nervosa or atypical anorexia nervosa with premorbid overweight/obesity: What should we do about their weight loss?
Authors: Jhe Grace B. , Lin Jessica , Freizinger Melissa , Richmond Tracy 
Published: September 2022

AbstractTraditionally, anorexia nervosa (AN) was understood to exist exclusively among underweight individuals and weight was used to assess level of severity and course of treatment. Recent trends have found a growing number of individuals presenting with AN or atypical AN (AAN) (i.e., those who remain with weight in a “normal” or “healthy” range despite significant weight loss) have a premorbid history of overweight/obesity. Individuals with AN/AAN and premorbid overweight/obesity represent an especially metabolically vulnerable population as with either AN or AAN, there is marked weight loss. Patients with AAN present a specific challenge as healthcare professionals must identify a clinically significant eating disorder in adolescents of potentially “normal” weights and then must balance their knowledge and training of traditional treatment of AN with obesity treatment and prevention. Currently, there are no evidence‐based treatments to guide medical and mental health professionals regarding weight restoration, medical stabilization, and psychological treatment in patients with AN/AAN with a history of overweight/obesity while also addressing risk prevention for obesity.