bluuebunny/crossref_metadata_2025_split huggingface dataset:
Adrenoleukodystrophy: An X-Linked Leukodystrophy With Predominent Neurological Manifestation : A Case Report
Authors: Majumder Shiuly , Azam Akramul , Biswas Rajat Kumar , Kayasthagir Pradip Kumar , Paul Nandita 
Published: October 2022

Leukodystrophy cases are not common in routine clinical practice. Among leukodystrophies adrenoleukodystrophy (ALD) cases are more common. It presents with neurologic and endocrine features with characteristic Megnetic Resonance Image (MRI) findings and biochemical changes. Early recognition of index case is important because dietary modification & supplementation with Lorenzo’s oil can slow progression of the disease course and can be life saving. Bone Marrow Transplantation (BMT) if performed in earlier stage of disease can be very rewarding to show stabilization and in some instances improvement of patient’s condition. More over prenatal diagnosis of affected boys can be performed by analyzing pedigree chart of an affected family members of this X-linked chromosomal disease.
JCMCTA 2016 ; 27 (1) : 68 - 71
Pleural Effusion: A Rare Complication Of Hepatitis a Infection in Children
Authors: Barua Sanat Kumar , Muhuri Basana Rani , Chowdhury Pranab Kumar , Hasan Mohammad Shameem , Sikder Abdur Razzak 
Published: October 2022

Hepatitis a Virus Is a Very Common Infection In The Pediatric Age Group, Especially in Developing Countries and Pleural Effusion Is One of It Rare Extra-Hepatic Complication. Here We Are Reporting a Case of Acute Hepatitis a Infection, Complicated With Pleural Effusion.
JCMCTA 2016 ; 27 (1) : 72 - 74
Metformin Hypersensitivity: A Case Report
Authors: Chowdhury Abhijit , Ferdoush Jannatul , Chowdhury Amalendu Bikash 
Published: October 2022

Metformin is a popular oral antidiabetic medicine of the Biguanide class. It is widely chosen as the first line therapy for treating Type 2 Diabetes Mellitus. The drug is believed to be a comparatively safer agent for controlling blood sugar. This case report aims at describing an unusual phenomenon of Metformin hypersensitivity in a female patient who presented with perioral lesions.
JCMCTA 2016 ; 27 (1) : 75 - 76
Pembuatan pupuk kompos cair dari buah limbah
Authors: - Deselina , Suharto Edi , - Wiryono 
Published: October 2022

Salah satu produk tanaman holtikultura yang tumbuh subur di negara kita adalah buah-buahan. Buah-buahan mengandung vitamin dan mineral yang sangat dibutuhkan oleh tubuh karena tubuh tidak dapat memproduksi vitamin dan mineral. Buah-buahan yang yang mudah rontok seperti jambu air dan belimbing biasanya tidak dikonsumsi karena fisiknya sudah rusak. Akhirnya buah-buah tersebut menjadi limbah dan dibuang. Limbah buah tersebut dapat dijadikan bahan baku dalam pembuatan pupuk kompos cair. Desa Arga Indah I yang merupakan lokasi kegiatan ini termasuk ke dalam wilayah Kecamatan Pagar Jati Kabupaten Bengkulu Tengah, Propinsi Bengkulu. Tujuan dari kegiatan pengabdian pada masyarakat ini adalah agar khalayak sasaran dapat memproduksi pupuk kompos cair dari limbah buah. Metode yang dipakai dalam kegiatan ini adalah dengan melakukan penyuluhan, pelatihan, dan demonstrasi pembuatan pupuk kompos cair dari limbah buah. Dari hasil penyuluhan dan pelatihan, khalayak sasaran mengerti tentang cara mengelola limbah buah untuk dijadikan pupuk kompos cair. Diharapkan dari hasil praktek, para khalayak sasaran yang terdiri dari anggota karang taruna dan anggota PKK Desa Arga Indah I dapat menghasilkan pupuk kompos cair yang bermutu dari limbah buah.
Pelatihan Strategi Pemasaran Produk Olahan Hasil Tangkap yang Berdaya Saing di Kampung Nelayan, Kota Tarakan
Authors: Hatta Djuanda , Darmawanto Agus Tri , Devi Charitin , Simangunsong Bernadeth Y. P. Br 
Published: October 2022

Indonesia merupakan penghasil produk utama hasil pertanian (dalam arti luas) yang beberapa diantaranya memiliki keunggulan komparatif di dunia. Salah satu daerah di Kota Tarakan yang semua masyarakatnya perprofesi sebagai Nelayan Tangkap adalah Kampung Nelayan di Kelurahan Mamburungan. Hasil tangkapan nelayan umumnya langsung dijual dalam bentuk produk mentah. Masyarakat mulai mengolah hasil tangkapan secara sederhana dan bersifat usaha rumahan. Oleh karena itu, kami bermitra dengan masyarakat setempat bagaimana upaya dalam pengolahan hasil tangkapan nelayan. Masih lemahnya daya saing merupakan permasalahan yang dihadapi oleh usaha mikro, kecil dan menegah. Kegiaatan bertujuan untuk meningkatkan strategi pemasaran produk olahan yang dilakukan di masyarakat kampug nelayan Kota Tarakan. Metode kegiatan dilakukan dengan treatment langsung ke ibu rumah tangga dengan mengujian pemahaman sebelum dan setelah pelatihan dengan analisis persentase penguasaan penggunaan applikasi. Kegiatan yang telah dilakukan adalah pelatihan pemanfaatan applikasi jual beli online dan applikasi transaksi elektronik. Dengan dilaksanakan pelatihan ini, para peserta yang berjumlah 10 orang yang merupakan ibu rumah tangga/istri nelayan telah mampu melakukan digital marketing dengan tingkat penguasaan 68,33% menggunakan applikasi jual beli online dan transaksi elektronik dengan menggunakan dompet digital dan mobile banking yang sebelumnya mereka hanya memanfaatkan fasilitas media sosial untuk bertransaksi.
Monocyte to HDL Ratio in Preeclamptic Patients: Can It Be a Predictive Marker?
Authors: YILDIRIM KÖPÜK Şule , NACİ Nida , ÖZCAN Canan , ULU İpek 
Published: October 2022

Objective: Preeclampsia (PE) is a severe and high – risk pregnancy complication for both the mother and fetus. Generalized inflammation is a prominent feature of PE. Based on the proinflammatory property of monocytes and the contrary anti-inflammatory mechanism of High-density lipoprotein (HDL), monocyte count to HDL ratio (MHR) could be used as a new marker of systemic inflammation. Our aim is to evaluate the relationship between PE and MHR in terms of diagnosis of PE.
Methods: A retrospective case-control study was recruited preeclamptic and healthy pregnant women in the third trimester of gestation (n=69 and n= 71, respectively).
Results: Maternal age (years), gravity, and body mass index (BMI) were similar in the two groups. The gestational week at delivery was significantly earlier in the PE group than in the control group (p < 0.001). Fetal weight in PE was significantly lower than in the control group (p = 0.001). Monocyte counts were comparable between the two groups (0.76 ± 0.28 vs. 0.76 ± 0.71; p = 0.25). The mean HDL level of PE patients was lower than the control group, but it was not statistically significant (63.87 ± 15.3 vs. 68.23 ± 13.5; p = 0.77). The monocyte/HDL ratio was higher in the PE group, but this increment did not reach statistical significance (12.5 ± 5.9 vs. 10.9 ± 4.3, p = 0.08).
Conclusion: MHR might be a new marker of inflammation and oxidative stress. The present study did not reach a result indicating a diagnostic marker of PE. Further studies with more cases are needed to evaluate the relationship between MHR and PE.
Long coverage with drug-eluting stents is superior to spot coverage for long femoropopliteal artery disease: PARADE II study
Authors: Park Jong-Il , Ko Young-Guk , Lee Yong-Joon , Lee Seung-Jun , Hong Sung-Jin , Ahn Chul-Min , Kim Jung-Sun , Kim Byeong-Keuk , Hong Myeong-Ki , Yu Cheol-Woong , Rha Seung-Woon , Park Jong-Kwan , Min Pil-Ki , Yoon Chang-Hwan , Lee Sang-Rok , Park Sang-Ho , Choi Dong-Hoon 
Published: October 2022

BackgroundThe efficacy of spot stenting using drug-eluting stents (DES) for the treatment of long femoropopliteal (FP) lesion is unknown. This study aimed to compare clinical outcomes of long full coverage vs. spot coverage with DES for long FP artery disease.MethodsThis multicenter randomized trial compared long DES vs. spot DES for FP lesions longer than 150 mm. All lesions were treated with paclitaxel-eluting stents (Zilver PTX). The primary endpoint was primary patency at 12 months.ResultsThe study was terminated early after an interim analysis. A total of 103 patients (55 in the long DES group; 48 in the spot DES group) were eligible for analysis. There were no significant differences in baseline and lesion characteristics between groups. Total stent length was longer in the long DES group than in the spot DES group (225.6 ± 67.2 vs. 131.3 ± 48.7 mm, p &lt; 0.001). Technical success was achieved in all patients. There was a trend toward a higher primary patency rate at 12 months in the long DES group than in the spot DES group (87.5% vs. 67.5%, p = 0.120). The rate of survival free from target lesion revascularization was significantly higher in the long DES group than in the spot DES group (91.7% vs. 72.0%, p = 0.044). In multivariate Cox regression analysis, spot DES [hazard ratio (HR) 2.42, 95% confidence interval (CI) 1.14–5.12, p = 0.021] and postdilation (HR 0.27, 95% CI 0.09–0.79, p = 0.018) were identified as independent predictors for loss of patency at 12 months post-procedure.ConclusionsLong DES were more effective than spot DES for treating long FP lesions.Clinical trial registrationClinicaltrials.gov, identifier: NCT02701881.
Factors influencing clinicians' willingness to use an AI-based clinical decision support system
Authors: Choudhury Avishek 
Published: October 2022

BackgroundGiven the opportunities created by artificial intelligence (AI) based decision support systems in healthcare, the vital question is whether clinicians are willing to use this technology as an integral part of clinical workflow.PurposeThis study leverages validated questions to formulate an online survey and consequently explore cognitive human factors influencing clinicians' intention to use an AI-based Blood Utilization Calculator (BUC), an AI system embedded in the electronic health record that delivers data-driven personalized recommendations for the number of packed red blood cells to transfuse for a given patient.MethodA purposeful sampling strategy was used to exclusively include BUC users who are clinicians in a university hospital in Wisconsin. We recruited 119 BUC users who completed the entire survey. We leveraged structural equation modeling to capture the direct and indirect effects of “AI Perception” and “Expectancy” on clinicians' Intention to use the technology when mediated by “Perceived Risk”.ResultsThe findings indicate a significant negative relationship concerning the direct impact of AI's perception on BUC Risk (ß = −0.23, p &lt; 0.001). Similarly, Expectancy had a significant negative effect on Risk (ß = −0.49, p &lt; 0.001). We also noted a significant negative impact of Risk on the Intent to use BUC (ß = −0.34, p &lt; 0.001). Regarding the indirect effect of Expectancy on the Intent to Use BUC, the findings show a significant positive impact mediated by Risk (ß = 0.17, p = 0.004). The study noted a significant positive and indirect effect of AI Perception on the Intent to Use BUC when mediated by risk (ß = 0.08, p = 0.027). Overall, this study demonstrated the influences of expectancy, perceived risk, and perception of AI on clinicians' intent to use BUC (an AI system). AI developers need to emphasize the benefits of AI technology, ensure ease of use (effort expectancy), clarify the system's potential (performance expectancy), and minimize the risk perceptions by improving the overall design.ConclusionIdentifying the factors that determine clinicians' intent to use AI-based decision support systems can help improve technology adoption and use in the healthcare domain. Enhanced and safe adoption of AI can uplift the overall care process and help standardize clinical decisions and procedures. An improved AI adoption in healthcare will help clinicians share their everyday clinical workload and make critical decisions.
Biodegradation of 2-4-6 trichlorophenol by sequencing batch reactors (SBR) equipped with a rotating biological bed and operated in an anaerobic-aerobic condition
Authors: Ghochlavi Nahid , Aghapour Ali Ahmad , Khorsandi Hassan 
Published: October 2022

2-4-6 Trichlorophenol (TCP) is toxic, carcinogenic, and resistant to biodegradation. In this study, a rotating biological bed (RBB) was used to improve the efficiency of Sequencing batch reactors (SBR), and it was operated in sequential anaerobic and aerobic conditions. Biofilm growth on media of rotating biological bed was also confirmed using Scanning Electron Microscope (SEM). In this study, the effect of 2-4-6 trichlorophenol concentration (5–430 mg/L), hydraulic retention time (HRT) (12–30 h), the number of operating cycles per day (6–12 cycles/d), the type of combination of anaerobic and aerobic processes and the presence of a rotating biological bed and its rotation were studied. SBR equipped with a rotating biological bed (SBR-RBB) with the sequential anaerobic-aerobic operation in optimal operating conditions (TCP: 430 mg/L, cycles/d: 8, and HRT: 6 h) can remove nearly 100% of TCP and more than 95% of TP and COD. The role of the presence of an RBB in removing TCP, TP, and COD was 7, 20, and 23%, respectively. The role of rotation of RBB also was 23%, 10, 21, and 62%, respectively. So, SBR-RBB, with the sequential anaerobic-aerobic operation, was able to remove higher concentrations of TCP (430 mg/L) in a shorter HRT (6 h) with higher efficiency (nearly 100%) compared to previous studies. Therefore, for the first time in this study, the biological treatment of 430 mg/L of TCP is reported by a biological process.
The role of cuproptosis-related gene in the classification and prognosis of melanoma
Authors: Liu Jin-Ya , Liu Le-Ping , Li Ze , Luo Yan-Wei , Liang Fang 
Published: October 2022

BackgroundMelanoma, as one of the most aggressive and malignant cancers, ranks first in the lethality rate of skin cancers. Cuproptosis has been shown to paly a role in tumorigenesis, However, the role of cuproptosis in melanoma metastasis are not clear. Studying the correlation beteen the molecular subtypes of cuproptosis-related genes (CRGs) and metastasis of melanoma may provide some guidance for the prognosis of melanoma.MethodsWe collected 1085 melanoma samples in The Cancer Genome Atlas(TCGA) and Gene Expression Omnibus(GEO) databases, constructed CRGs molecular subtypes and gene subtypes according to clinical characteristics, and investigated the role of CRGs in melanoma metastasis. We randomly divide the samples into train set and validation set according to the ratio of 1:1. A prognostic model was constructed using data from the train set and then validated on the validation set. We performed tumor microenvironment analysis and drug sensitivity analyses for high and low risk groups based on the outcome of the prognostic model risk score. Finally, we established a metastatic model of melanoma.ResultsAccording to the expression levels of 12 cuproptosis-related genes, we obtained three subtypes of A1, B1, and C1. Among them, C1 subtype had the best survival outcome. Based on the differentially expressed genes shared by A1, B1, and C1 genotypes, we obtained the results of three gene subtypes of A2, B2, and C2. Among them, the B2 group had the best survival outcome. Then, we constructed a prognostic model consisting of 6 key variable genes, which could more accurately predict the 1-, 3-, and 5-year overall survival rates of melanoma patients. Besides, 98 drugs were screened out. Finally, we explored the role of cuproptosis-related genes in melanoma metastasis and established a metastasis model using seven key genes.ConclusionsIn conclusion, CRGs play a role in the metastasis and prognosis of melanoma, and also provide new insights into the underlying pathogenesis of melanoma.
Use of convolutional neural networks in skin lesion analysis using real world image and non-image data
Authors: Wong Samantha C. , Ratliff William , Xia Meng , Park Christine , Sendak Mark , Balu Suresh , Henao Ricardo , Carin Lawrence , Kheterpal Meenal K. 
Published: October 2022

BackgroundUnderstanding performance of convolutional neural networks (CNNs) for binary (benign vs. malignant) lesion classification based on real world images is important for developing a meaningful clinical decision support (CDS) tool.MethodsWe developed a CNN based on real world smartphone images with histopathological ground truth and tested the utility of structured electronic health record (EHR) data on model performance. Model accuracy was compared against three board-certified dermatologists for clinical validity.ResultsAt a classification threshold of 0.5, the sensitivity was 79 vs. 77 vs. 72%, and specificity was 64 vs. 65 vs. 57% for image-alone vs. combined image and clinical data vs. clinical data-alone models, respectively. The PPV was 68 vs. 69 vs. 62%, AUC was 0.79 vs. 0.79 vs. 0.69, and AP was 0.78 vs. 0.79 vs. 0.64 for image-alone vs. combined data vs. clinical data-alone models. Older age, male sex, and number of prior dermatology visits were important positive predictors for malignancy in the clinical data-alone model.ConclusionAdditional clinical data did not significantly improve CNN image model performance. Model accuracy for predicting malignant lesions was comparable to dermatologists (model: 71.31% vs. 3 dermatologists: 77.87, 69.88, and 71.93%), validating clinical utility. Prospective validation of the model in primary care setting will enhance understanding of the model’s clinical utility.
Photocatalytic degradation of tetracycline antibiotic over a flower-like S-doped BiOBr: Performance, mechanism insight and toxicity assessment
Authors: Huang Jianghua , Li Cunjun , Hao Huadong , Li Liang , Zhu Baikang , Chen Xianlei , Tao Hengcong 
Published: October 2022

A new catalyst of S-BiOBr flower-like morphology was synthesized by simple pyrolysis and further used for photocatalytic degradation of TC. Phase structure analysis, elemental analysis and micromorphological analysis confirmed that S doping has a reinforcing effect on the polarization between the [Bi2O2S]2+ and [Br2]2- layers and is conducive to interlayer polarization and rapid charge transfer. In addition, its unique petal morphology is more favorable to the adsorption of contaminants on its surface and accelerates the reaction of catalyst surfactant with contaminants. It was also found that S-BiOBr degrades TC significantly better than single BiOBr@HCs, with up to 99.1% in 60 min illumination. In addition, the S-BiOBr catalyst has good reusability in antibiotic degradation. The results of photocatalytic mechanism analysis show that free radical O2− plays a major role in the photodegradation of organic model pollutants. Intermediates in TC degradation were identified, and their potential degradation pathways were prospected, and the toxicity development of TC in the degradation process was analyzed by toxicity assessment software. The S-BiOBr photocatalytic system developed in this paper provides a new idea for effective modification of bismuth-based semiconductors and has important guiding significance for future water purification.
Risk and prognostic factors for SARS-CoV-2 infection in Spanish population with multiple sclerosis during the first five waves
Authors: Pilo De La Fuente Belén , González Martín-Moro Julio , Martín Ávila Guillermo , Méndez Burgos Alejandro , Ramos Barrau Laura , Thuissard Israel , Torrejón Martín Marta , Aladro Benito Yolanda 
Published: October 2022

BackgroundData on coronavirus disease 2019 (COVID-19) incidence in patients with multiple sclerosis (MS) during the first wave have been published but are scarce for the remaining waves. Factors associated with COVID-19 infection of any grade are also poorly known. The aim of this study was to analyze the incidence, clinical features, and risk factors for COVID-19 infection of any grade in patients with MS (pwMS) during waves 1–5.MethodsThis study prospectively analyzes the cumulative incidence of COVID-19 from the first to the fifth waves by periodic case ascertainment in pwMS followed at the University Hospital of Getafe (UHG). Global and stratified cumulative incidence was calculated. Logistic regression models were used to estimate the weight of selected variables as risk and prognostic factors.ResultsWe included 431 pwMS, of whom 86 (20%) were infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The overall cumulative incidence of confirmed cases was similar to that of Madrid (13,689 vs. 13,307 per 100,000 habitants) but 3 times higher during the first wave and slightly lower from the second to the fifth waves. The majority (86%) of pwMS developed mild forms of COVID-19. Smoking was the only factor associated with a decreased risk of SARS-CoV2 infection of any grade [odds ratio (OR) 0.491; 95% CI 0.275–0.878; p = 0.017]. Risk factors associated with severe forms were Expanded Disability Severity Scale (EDSS) ≥3.5 (OR 7.569; 95% CI 1.234–46.440) and pulmonary disease (OR 10.763; 95% CI 1.27–91.254).ConclusionThe incidence of COVID-19 was similar in this MS cohort to the general population. Smoking halved the risk of being infected. Higher EDSS and pulmonary comorbidity were associated with an increased risk of severe forms.
Body mass index, blood glucose, and mortality in patients with ischemic stroke in the intensive care unit: A retrospective cohort study
Authors: Ma Zisheng , Li Shunxian , Lin Xinjiang 
Published: October 2022

BackgroundExcessive BMI was associated with lower mortality after stroke. However, some believed that excessive BMI can lead to a poor prognosis because of some physiological mechanism, such as glucose metabolism disorder. Therefore, this study aims to discuss the association between mortality, BMI, and blood glucose.Materials and methodsThis was a retrospective observational study and all data were extracted from the Medical Information Mart for Intensive Care III database. The exposure was BMI classified into the normal weight group and the excessive weight group. The outcome concluded 30-day, 90-day, and 1-year mortality. The association between two groups and mortality was elucidated by Cox regression models, propensity score matching (PSM) and inverse probability of treatment weighting (IPTW). The underlying effect of blood glucose on the “obesity paradox” was analyzed by causal mediation analysis.ResultsAccording to Cox regression models, a significant beneficial effect of excessive BMI in terms of mortality was observed: 30-day mortality (HR 0.57, 95% CI 0.35–0.90, P = 0.017), 90-day mortality (HR 0.53, 95% CI 0.36–0.78, P = 0.001), and 1-year mortality (HR 0.65, 95% CI 0.46–0.91, P = 0.013). After PSM and IPTW, we got a similar conclusion. The causal mediation analysis showed that the protective effect of excessive BMI on 30-day mortality reduced with the increase of blood glucose.ConclusionFor ischemic stroke patients in the Intensive Care Unit, those with excessive BMI are associated with both lower short-term mortality and lower long-term mortality, while the protective effect on 30-day mortality weakened accompanied by the increase of blood glucose.