bluuebunny/crossref_metadata_2025_split huggingface dataset:
Establishing a blockchain online travel agency with a human–computer interaction perspective
Authors: Su Kuo-Wei , Chiu Po-Chih , Lin Tzu-Hsiang 
Published: April 2022

Purpose
This study aims to incorporate innovative technology (i.e. blockchain) into the design of an online travel agency (B-OTA). The authors accelerated the design of the prototype system through expert interviews to understand the convenience of the blockchain travel and accommodation platform for users. The authors further validated the prototype system design and improved reference capability through usability testing.

Design/methodology/approach
Rapid prototyping of B-OTA was carried out through the Delphi method and literature compilation. Design validation of usability testing was conducted using modified systematic evaluation methodology. Prototype system suggestions and improvements were collected through feedback from test subjects.

Findings
This study will be helpful for the development of B-OTAs and related technologies. Through usability testing, the authors verified that creating a familiar operating environment for users can reduce users’ fear of unfamiliar technology. The results of this research provide future B-OTA researchers and practitioners with design guidelines.

Originality/value
Beyond the blockchain-related technologies used, few studies have reported experiences and interface design of B-OTAs. This study states that, as many human–computer interaction-related papers have pointed out, the basic prerequisite for successful interface design is a clearer definition of users’ needs during operation. User experience and user interface design should provide a good user experience.
Subsidiary strategic influence: the role of subsidiary attention-building activities
Authors: Gorgijevski Alexander N. , Holmström Lind Christine , Lagerström Katarina 
Published: April 2022

PurposeBy the view of attention-building activities as “tools of power,” the authors investigate the impact of subsidiary involvement in attention-building activities on the strategic influence of subsidiaries within multinational corporations (MNCs).Design/methodology/approachThe study is based on survey data from 110 international subsidiaries located in Sweden. Five hypotheses were tested using structural equation modeling with linear structural relations.FindingsThe study shows that organizational commitment and external scouting activities, as two attention-building activities, do not directly affect the ability of subsidiaries to gain a strategic influence in MNCs. Rather, the results provide support for the importance of headquarters’ positive attention as a mediator between such activities and subsidiary strategic influence. This implies that subsidiaries do not receive any strategic influence through these activities unless they receive explicit positive attention from the corporate headquarters.Originality/valueThis study contributes to the micro-political view of the MNC by offering insights into the impact of attention-building activities of subsidiaries as a potential source of strategic influence for MNC subsidiaries.
Flipped classroom goes sideways: reflections on active learning methodologies
Authors: Leão Pablo , Coelho Caio , Campana Carla , Viotto Marina Henriques 
Published: April 2022

PurposeThe present study aims to investigate an unsuccessful implementation of an active learning methodology. Active learning methods have emerged in order to improve learning processes and increase students' roles in the classroom. Most studies on the subject focus on developing learning strategies based on successful implementations of such methods. Nevertheless, critical reflections on unsuccessful cases might also provide material for developing further contributions to this literature.Design/methodology/approachThe authors conducted an intrinsic case study of an unsuccessful application of the flipped classroom method to an undergraduate basic statistics course at a Brazilian business school. The data collected comprised the course's syllabus, evaluation forms and two rounds of interviews with students and the professor.FindingsThe findings indicate that, apart from that which had been mapped by past literature, three additional aspects may limit the chances of successfully implementing a flipped classroom methodology: students' educational backgrounds, the course's structural issues and methodological and relational issues.Originality/valueThe present study contributes to the literature on active learning methodologies mainly by mapping additional aspects that should be considered in the implementation of the flipped classroom methodology. Additionally, the authors investigate an unsuccessful case of such an implementation, an investigation that is still scant within this literature.
De‐migration‐based supervised learning for interpolation and regularization of 3D offset classes
Authors: Hlebnikov Volodya , Greiner Thomas Andre Larsen , Vinje Vetle , Lie Jan Erik , Poole Gordon 
Published: April 2022

ABSTRACTRegularization and interpolation of 3D offset classes prior to imaging are an important and challenging step in the marine seismic data processing flow. Here we describe how to perform this task using a deep neural network, and we explain how to overcome the challenge of creating a suitable training data set. The training data set is generated by de‐migrating stacked pre‐stack depth migration images. For each offset class volume, we de‐migrate the pre‐stack depth migrated stacked image into two configurations: (i) the original survey configuration consisting of the recorded source/receiver positions and (ii) an ‘Ideal’ survey configuration with constant offset and azimuth for each 3D offset class. The training creates a 3D convolutional encoder–decoder model that will regularize and interpolate seismic data. The convolutional encoder–decoder is trained on 3D sliding windows in each 3D offset cube to map from (i) to (ii), i.e. to map the original survey configuration with irregular and sparse sampling into the fully sampled regular offset cubes suitable for offset‐based migration, such as Kirchhoff migration. Such migration algorithms rely on regular and sufficiently dense sampling to achieve constructive interference to image the structures and destructive interference to suppress migration noise. We test the new method on one synthetic and one field data example and show that it performs better than a standard regularization/interpolation method based on anti‐leakage Fourier transform, especially for the smallest offset classes. On the synthetic data, we also demonstrate that the convolutional encoder–decoder method preserves the amplitude versus offset as well as the standard method.
Does preventive dental care reduce nonpreventive dental visits and expenditures among Medicaid‐enrolled adults?
Authors: Taylor Heather L. , Sen Bisakha , Holmes Ann M. , Schleyer Titus , Menachemi Nir , Blackburn Justin 
Published: April 2022

AbstractObjectiveTo determine whether preventive dental visits are associated with fewer subsequent nonpreventive dental visits and lower dental expenditures.Data SourcesIndiana Medicaid enrollment and claims data (2015–2018) and the Area Health Resource File.Study DesignA repeated measures design with individual and year fixed effects examining the relationship between preventive dental visits (PDVs) and nonpreventive dental visits (NPVs) and dental expenditures.Data Collection/Extraction MethodsNot applicable.Principal FindingsOf 28,152 adults (108,349 observation‐years) meeting inclusion criteria, 36.0% had a dental visit, 27.8% a PDV, and 22.1% a NPV. Compared to no PDV in the prior year, at least one was associated with fewer NPVs (β = −0.13; 95% CI –0.12, −0.11), lower NPV expenditures (β = −$29.12.53; 95% CI –28.07, −21.05), and lower total dental expenditures (−$70.12; 95% –74.92, −65.31), as well as fewer PDVs (β = −0.24; 95% CI –0.26, −0.23).ConclusionsOur findings suggest that prior year PDVs are associated with fewer subsequent NPVs and lower dental expenditures among Medicaid‐enrolled adults. Thus, from a public insurance program standpoint, supporting preventive dental care use may translate into improved population oral health outcomes and lower dental costs among certain low‐income adult populations, but barriers to consistent utilization of PDV prohibit definitive findings.
‘It Takes Two to Tango’: South–South Cooperation Measurement Politics in a Multiplex World
Authors: Trajber Waisbich Laura 
Published: April 2022

AbstractThis paper examines whether and how the imperatives of measuring Official Development Assistance (ODA; or development aid) are being translated to the policy world of South–South cooperation (SSC). Through a historical and political ethnographic account of a decade of global policy debates on Southern‐led development cooperation between 2009 and 2019, the paper argues that growing conversations on ‘SSC effectiveness’, and how to measure it, reflect both prevalent ‘measurementalities’ in the field as well as ‘traditional/Northern donor countries’ continuous will to socialise and integrate ‘(re)‐emerging Southern providers’ into existing aid norms and practices. The paper also demonstrates Southern powerhouses'—such as Brazil, China, and India—agency in these accountability‐related debates and their will to integrate differently into the ‘aid system’ by proposing alternative tools to measure SSC flows and initiatives in their own terms. Finally, the paper argues that unfolding negotiations over quantifying, reporting, and evaluating Southern‐led development cooperation reflect the politicised consolidation of SSC in the second decade of the 21st century. Current impasses at the multilateral level, moreover, reveal unsolved North–South disputes over power, status, and responsibility in international development and international affairs, more broadly.
Ex‐gay activism and the reification of sexual identity in law
Authors: McIvor Méadhbh 
Published: April 2022

AbstractThe increasing visibility of sexualities beyond heterosexual, gay/lesbian, and bisexual is often associated with progressive politics and the questioning of heteronormativity. Yet non‐majoritarian sexualities can also include self‐identifications premised upon an opposition to LGBTQ+ equality and inclusion, including those who identify as “ex‐gay.” Drawing on fieldwork with evangelical Christian activists in London, UK, this paper uses a court case in which the “legality” of ex‐gay sexuality was contested to discuss the law's simultaneous desire and inability to render contested identities legally legible. In seeking recognition as a sexual minority, self‐described ex‐gay evangelicals reveal the inadequacy of modern law's efforts to regulate difference as either “innate” or “chosen,” thus upsetting the terms of the hetero‐secular legal gaze even as they embrace heterosexual supremacy. As such, this activism, which is typically analyzed in terms of evangelicalism's commitment to heteronormativity, works to denaturalize the concept of sexual orientation(s)—including, I argue, the heterosexuality ex‐gay Christians pursue.
Acetyl‐L‐carnitine improves erectile function in bilateral cavernous nerve injury rats via promoting cavernous nerve regeneration
Authors: Wang Jiaxin , Song Jingyu , Song Guoda , Feng Yuhong , Pan Jiancheng , Yang Xiaoqing , Xin Zhongcheng , Hu Peng , Sun Taotao , Liu Kang , Xu Wenchao , Wang Tao , Wang Shaogang , Liu Jihong , Ruan Yajun 
Published: April 2022

AbstractBackgroundNeurogenic erectile dysfunction (NED) caused by cavernous nerve (CN) injury is a typical complication after pelvic surgery, which lacks efficient treatments. Acetyl‐L‐carnitine (ALCAR) has been proven to promote nerve repair.ObjectivesTo investigate the effect and potential mechanism of ALCAR in the treatment of NED.Materials and methodsThirty‐two rats were randomly divided into bilateral CN injury (BCNI) group, BCNI + lower‐dose ALCAR (50 mg/kg/day) group, BCNI + higher‐dose (100 mg/kg/day) group, and sham‐operated group. Erectile function was assessed 14 days after daily intraperitoneal injection of ALCAR or placebo. The penile tissues were gathered for subsequent histological and molecular biological analysis. Rat Schwann cell (SC) line S16 was used to verify the mechanism of ALCAR in vitro.ResultsWe found that the erectile function of the rats in the BCNI group was severely impaired, which was improved considerably in both BCNI+ALCAR‐LD and BCNI+ALCAR‐HD groups. Also, we observed decreased smooth muscle and increased collagen content in the corpus cavernosum in the BCNI group. The expressions of fibrosis markers transforming growth factor‐beta (TGF‐β), connective tissue growth factor (CTGF), and Smad 2/3 were significantly up‐regulated in the BCNI group. The above changes were alleviated after the administration of lower and higher‐dose ALCAR. Meanwhile, the nitric oxide (NO)/cyclic guanosine monophosphate pathway (cGMP) was promoted and the Ras homolog gene family member A (RhoA)/Rho‐associated protein kinase (ROCK) pathway was inhibited in the corpus cavernosum of BCNI rats after ALCAR treatment, accompanied by increased neuronal nitric oxide synthase (nNOS) and down‐regulated tyrosine hydroxylase (TH). In vitro, ALCAR promoted the migration and proliferation of SC and increased the expression of 22‐kD peripheral myelin protein and nerve growth factor (NGF). Further, rats treated with ALCAR had high expression of ATF3 and S100 in the distal nerve tissues of the CN extrusion site.Discussion and conclusionALCAR could promote nerve repair and regeneration, inhibit penile fibrosis, and improve penile erection by promoting the proliferation and migration of SC and the secretion of NGF. Our study confirms that ALCAR may be a potential treatment strategy for NED.
Impact of pre‐emptive rapid testing for glucose‐6‐phosphate dehydrogenase deficiency prior to rasburicase administration at a tertiary care centre: A retrospective study
Authors: Ganapathi Mythily , Campbell Peter , Ofori Kenneth , Aggarwal Vimla , Francis Richard O. , Kratz Alexander 
Published: April 2022

AimsGlucose‐6‐phosphate dehydrogenase (G6PD) deficiency, the most common enzymopathy in humans, can cause acute haemolysis resulting from exposure to certain medications, chemicals, infections and fava beans. Rasburicase, used to manage elevated uric acid levels in the oncologic emergency of tumour lysis syndrome, is one such drug. The US Food and Drug Administration (FDA) recommends testing of G6PD status prior to rasburicase administration for patients at higher risk for G6PD deficiency.MethodsWe performed a retrospective chart review of all oncology patients for whom a semi‐quantitative biochemical test for detecting G6PD deficiency was performed prior to rasburicase administration over a 2.5‐year period, in a large academic metropolitan hospital.ResultsWe identified 16 out of 260 tested individuals as G6PD‐deficient (6.1%), including six females. On average, test results were electronically available to health care providers within 4 hours of sample collection, with most results available within 2–3 hours. Four G6PD‐deficient patients developed elevated uric acid levels. Two of the G6PD‐deficient patients were treated with rasburicase, and subsequently developed haemolysis, which was appropriately managed.ConclusionIn summary, by providing information about G6PD status with a rapid turnaround time, we have taken a significant step towards personalized medicine in our institution. In spite of the test implementation, two out of four G6PD‐deficient patients, who were no longer candidates for rasburicase use, still received the drug, highlighting the need for improved provider education.
Identification of clinical factors related to antibody‐mediated immune response to the subfornical organ
Authors: Nakamura‐Utsunomiya Akari , Goda Satoshi , Hayakawa Seiichi , Sonoko Sakata , Hoorn Ewout J. , Blanchard Anne , Saito‐Hakoda Akiko , Kakimoto Haruna , Hachiya Rumi , Kamimura Miki , Kawakita Rie , Higuchi Shinji , Fujimaru Rika , Shirai Yoko , Miyaoka Daichi , Nagata Yuki , Kishi Yutaro , Wada Aya , Mitsuboshi Akari , Ozaki Kayo , Komatsu Nagisa , Niizuma Hidetaka , Kanno Junko , Fujiwara Ikuma , Hasegawa Yukihiro , Yorifuji Tohru , Brickman Wendy , Vantyghem Marie‐Christine , Yamaguchi Kei , Goshima Naoki , Hiyama Takeshi Y. 
Published: April 2022

AbstractObjectiveWe recently reported cases of adipsic hypernatremia caused by autoantibodies against the subfornical organ in patients with hypothalamic‐pituitary lesions. This study aimed to clarify the clinical features of newly identified patients with adipsic hypernatremia whose sera displayed immunoreactivity to the mouse subfornical organ.DesignObservational cohort study of patients diagnosed with adipsic hypernatremia in Japan, United States, and Europe.MethodsThe study included 22 patients with adipsic hypernatremia but without overt structural changes in the hypothalamic‐pituitary region and congenital disease. Antibody response to the mouse subfornical organ was determined using immunohistochemistry. The clinical characteristics were compared between the patients with positive and negative antibody responses.ResultsAntibody response to the mouse subfornical organ was detected in the sera of 16 patients (72.7%, female/male ratio, 1:1, 12 pediatric and 4 adult patients). The prolactin levels at the time of diagnosis were significantly higher in patients with positive subfornical organ (SFO) immunoreactivity than in those with negative SFO immunoreactivity (58.9 ± 33.5 vs. 22.9 ± 13.9 ng/ml, p < .05). Hypothalamic disorders were found in 37.5% of the patients with positive SFO immunoreactivity. Moreover, six patients were diagnosed with rapid‐onset obesity with hypothalamic dysfunction, hypoventilation, and autonomic dysregulation/neural tumor syndrome after the diagnosis of adipsic hypernatremia. Plasma renin activity levels were significantly higher in patients with serum immunoreactivity to the Nax channel.ConclusionsThe patients with serum immunoreactivity to the SFO had higher prolactin levels and hypothalamic disorders compared to those without the immunoreactivity. The clinical characteristics of patients with serum immunoreactivity to the subfornical organ included higher prolactin levels and hypothalamic disorders, which were frequently associated with central hypothyroidism and the presence of retroperitoneal tumors.
Different FT3/TSH correlation in acquired and congenital hypothyroid patients reveals a different hypothalamic set‐point
Authors: Russo Marco , Gullo Damiano , Tumino Dario , Leonardi Daniela , Malandrino Pasqualino , Frasca Francesco 
Published: April 2022

AbstractObjectiveTo understand differences in thyroid hormone replacement therapy with levo‐thyroxine (l‐T4) between acquired and congenital hypothyroid (CH) patients.DesignWe compared biochemical thyroid parameters between euthyroid subjects (EU) and both CH adult patients and thyroidectomized patients (TP) under replacement therapy.Patients and MeasurementsA retrospective analysis was performed on a series of 98 consecutive adult CH patients (27 males and 71 females) with a median age of 24 years (range 18−58). Serum TSH, FT3, FT4, l‐T4 dose and body weight were assessed. For comparison purposes, large series of 461 TP for thyroid cancer and 1852 EU followed at our Thyroid Clinic were used as control groups.ResultsThe daily weight‐based l‐T4 dose was significantly higher in CH than TP group (1.9 vs. 1.7 mcg/kg, p = .03). FT3/FT4 ratio was significantly higher in the EU group, intermediate in CH and lower in TP groups (0.32, 0.28 and 0.24, respectively). Linear regression analysis displayed an inverse correlation between FT4 and TSH in all the groups. An inverse correlation between FT3 and TSH was observed in the TP group, but not in the EU and CH group suggesting that CH patients, under replacement therapy, display biochemical thyroid parameters similar to EU subjects.ConclusionsAdult CH patients require a higher daily l‐T4 dose than adult TP. However, the different correlation of TSH and FT3 values between CH and TP patients suggests an adaptive and different hypothalamic−pituitary−thyroid axis regulation that may depend on the early timing of the onset of hypothyroidism in CH.
Suboptimal accuracy of ultrasound and ultrasound‐based risk stratification systems in detecting medullary thyroid carcinoma should not be overlooked. Findings from a systematic review with meta‐analysis
Authors: Ferrarazzo Giulia , Camponovo Chiara , Deandrea Maurilio , Piccardo Arnoldo , Scappaticcio Lorenzo , Trimboli Pierpaolo 
Published: April 2022

AbstractObjectiveUltrasound (US) is the pivotal procedure during the diagnostic work‐up of thyroid nodule and several US‐based risk stratification systems (RSSs) have been recently developed. Since the performance of RSSs in detecting medullary thyroid carcinoma (MTC) has been rarely investigated, the present systematic review aimed to achieve high evidence about (1) how MTC is classified according to RSSs; (2) if RSSs correctly classify MTC at high risk/suspicion, and (3) if MTC is classified as suspicious at US when RSSs are not used.DesignThe review was performed according to MOOSE. The online search was performed by specific algorithm on January 2022. A random‐effects model was used for statistical analysis.ResultsTwenty‐five papers were initially included and their risk of bias was generally low. According to ATA system, 65% of MTCs was assessed at high suspicion and 25% at intermediate suspicion. Considering all RSSs, a 54.8% of MTCs was put in a high‐risk/suspicion category. Pooling data from studies without data of RSS the prevalence of ultrasonographically suspicious MTCs was 60%.ConclusionsAs conclusion, MTC presentation according to RSSs is partially known and it is classified in a high‐risk/suspicion category of RSSs in just over a half of cases. This advises for further studies, ideally supported by international societies, to better define the US presentation of MTC.
Development and regulation of stem cell‐based therapies in China
Authors: Gao Jianchao , Gao Chenyan 
Published: April 2022

AbstractBackgroundClinical researches of stem cell‐based therapies are highly active in China, while it was arduous to determine the most effective way of clinical translation of those advanced therapies.MethodsThis article briefly introduced the regulatory framework development, the progress in stem cell clinical researches and clinical trials of commercially developed stem cell‐based products, as well as the clinical review concerns of stem cell‐based products in China.Main findingsThe current regulatory framework of stem cell clinical researches in China was launched in 2015, when regulatory authorities issued “Administrative Measures on Stem Cell Clinical Research” (AMSCCR) detailing the rules of stem cell clinical research. Thereafter, the rapidly growing stem cell clinical researches were rigorously managed and clinical use of stem cell therapy was halted. Meanwhile, commercially developed stem cell‐based products are supervised by Drug Administration Law (DAL).ConclusionThe regulatory framework of stem cell‐based therapy in China has progressed in the last few decades, which is currently regulated according to AMSCCR and DAL. Well‐designed and patient‐focused clinical trial is required for commercially developed stem cell‐based products, and definite clinical benefit evidence is crucial to obtain marketing authorization.
MORAL HAZARD IN REMOTE TEAMS
Authors: Bisetti Emilio , Tengelsen Benjamin , Zetlin‐Jones Ariel 
Published: April 2022

AbstractWe reexamine the ability of teams to credibly self‐impose group punishments and prevent free riding when individual inputs are unobservable. We formulate self‐imposed group punishments as performance underreporting by the team. Although underreporting is not credible in a static game, we show that simple strategies can sustain underreporting in a repeated game, and that the threat of underreporting improves welfare only if team members' preferences between shirking and team output consumption are nonseparable. Our results suggest that self‐assessments can replace increased managerial monitoring in remote work environments.