bluuebunny/crossref_metadata_2025_split huggingface dataset:
Associations between low-dose aspirin and bone mineral density in older adults
Authors: Liu Hongzhan , Shi Qiaojing , Tang Xianzhe , tian Yun , Xiao Xungang 
Published: March 2022

Abstract
Background: The utilization rate of low-dose aspirin in the elderly is increasing, and osteoporosis in the elderly is getting more and more attention. Aspirin has been shown in numerous studies to affect bone metabolism. However, there is no clear link between low-dose aspirin use and bone mineral density (BMD). This study examined differences in bone mineral density between low-dose aspirin users and non-aspirin users in adults aged 50-80 years.Methods: We conducted a cross-sectional study of 4987 participants aged 50–80 years who participated in the National Health and Nutrition Examination Survey (NHANES) 2017-March 2020. We performed multivariable logistic regression models to evaluate the associations between low-dose aspirin use and femoral neck BMD.Results: A total of 1143 adults were included in this study. Higher femoral neck BMD was observed in the low-dose aspirin use group compared with the non-aspirin use group (β=0.023, 95%CI 0.007-0.039). On subgroup analyses stratified by gender, this positive association existed in both gender after adjusting for confounders (males: β=0.020, 95%CI: -0.001-0.042; females: β=0.025, 95%CI: 0.001-0.050 P for interaction = 0.739). On subgroup analyses stratified by age, this positive association existed in three different age groups after adjusting for confounders (50-60 years: β=0.034, 95%CI: 0.004-0.065; 60-70 years: β=0.016, 95%CI: -0.011-0.043; 70-80 years: β=0.026, 95%CI: -0.003-0.055 P for interaction = 0.633).Conclusion: These findings from a human study looking into the correlation between low-dose aspirin use and femoral neck BMD suggest that taking regular low-dose aspirin may be associated with a higher femoral neck BMD. The effect of low-dose aspirin on femoral neck bone mineral density was not significant across age groups and genders.
STING promotes proliferation and induces drug resistance in colorectal cancer by regulating the AMPK-mTOR pathway
Authors: Yao Huihui , Wang Suo , Zhou Xin , Zhou Guoqiang , Zhou Diyuan , Chen Guoliang , Shi Xinyu , Chen Junjie , Wu Guanting , Sun Liang , Yao Yizhou , Gu Wen , Wan Daiwei , He Songbing 
Published: March 2022

Abstract
Background: Despite a rapidly growing body of pertinent literature, what role the protein stimulator of interferon genes (STING) plays in colorectal cancer (CRC) remains unclear. We are committed to exploring whether STING can be adopted as an effective target and biomarker for CRC. Methods: STING expression was examined by immunohistochemistry to evaluate its association with clinicopathological factors. In addition, the effects of STING on various biological characteristics of CRC cells, such as proliferation, migration, invasiveness and drug resistance, were also studied. Gene set enrichment analysis was an indispensable tool to study the downstream mechanism of STING. Meanwhile, we explored the effect of STING on glucose uptake. Results: Our study suggested that the expression of STING was not only up-regulated in CRC, but also correlated with TNM stage and poor prognosis. Moreover, STING regulates cell migration, proliferation, invasiveness and drug resistance via mediating AMPK-mTOR pathway. Finally, we confirmed that STING regulates energy metabolism in CRC cells. Conclusions: STING may be a promising biomarker and a target for chemosensitization and inhibition of CRC progression.
Crime-Specific Recidivism in Criminal Justice Clients with Substance Use - a Cohort Study
Authors: Karlsson Anna , Håkansson Anders 
Published: March 2022

Abstract

Background: Criminal recidivism is a major global concern. There is a well-known relation between substance use disorders and offending. Yet, little is known about crime-specific recidivism. The aim of this study was to investigate the relation between specific substance use and crime-specific recidivism. Methods: The study is based on 4,207 Swedish prison clients with substance use assessed with Addiction Severity Index interviews between 2001 and 2006. Clients were followed for an average of 2.7 years. Risk factors for criminal recidivism were assessed with Cox regression analysis. Results: Sixty-eight percent of the clients returned to the criminal justice system. Apart from well-known risk factors such as male gender and young age, amphetamine, injection drug use, prior prosecution for violent and property crime as well as homelessness and psychiatric problems were risk factors for criminal recidivism. Sedatives and cannabis were in this setting negative risk factors for general recidivism. Age, heroin and injection drug use elevated risks of recidivism to property and drug crime. Alcohol was associated with violent recidivism. Conclusions: Looking at different categories of crime separately, risk factors differed substantially. This further highlight the need for crime-specific research. Identifying crime-specific risk factors should be an important part of improving rehabilitation into society after imprisonment and hopefully decrease recidivism.
Inhibition of the TLR4/NF-κB/TNF-α axis by TAK-242 or PDTC reduces central nervous system inflammation to alleviate lipopolysaccharide induced sickness behaviors in mice
Authors: Tuo Peng , Wang Yanjie , Chen Weiming , Xie Jiehong , Jie Yingxi , Liu Jinfa , Liu Xianbao , Zhang Wei , Wang Shouping 
Published: March 2022

Abstract
Background: During the pathogenic microorganisms infection, animals will exhibit sickness behaviors, yet there is a lack of sufficient research on the pathogenesis of sickness behaviors and related treatments. We aim to ascertain the molecular mechanisms of lipopolysaccharide (LPS)-induced sickness behaviors and to find potential therapeutic methods.Methods: In this study, the mice with sickness behaviors elicited by LPS were utilized as the case group and the LPS-exposed mice treated with TAK-242 and PDTC were adopted as the treatment groups (TAK-242+LPS and PDTC+LPS), with PBS-treated mice as the control group. Expression patterns of nucleic acids, cytokines, or pathways were detected by transcriptome-wide analysis of hippocampal samples, enzyme-linked immunosorbent assay (ELISA), immunofluorescence staining, and Western blot assay.Results: Our results demonstrated marked cognitive dysfunction and emotional disorders in the LPS-induced sickness model mice, accompanied by activation of microglia and astrocytes in the hippocampus. RNAseq results showed 524 up-regulated genes and 126 down-regulated genes in the hippocampal tissues. Among them, 108 DEGs were involved in signal transduction, and NF-kappa B (NF-κB), Toll-like receptor (TLR), and TNF-α pathways were the pathways enriched with the largest number of genes. LPS-exposed mice were treated with two pathway inhibitors, TAK-242 and PDTC, respectively. Both of the two could significantly ameliorate the cognitive dysfunction caused by LPS, notably block the microglial activation in the hippocampus, and reduce the levels of neuroinflammatory factors such as IL-1a, IL-6, and TNF-α.Conclusion: Our results suggest that the TLR4/NF-κB/TNF-α axis may be a potential mechanism by which LPS-triggered neuroinflammation leads to sickness behaviors and that inhibitors TAK-242 and PDTC have potential therapeutic value.
SERPINB7, TMEM158, and SERPINE1 signature as predictors of non-small-cell lung cancer prognosis after intravenous vitamin C treatment
Authors: Ou Junwen , Liao Qiulin , Du Yanping , Xi Wentao , Meng Qiong , Li Kexin , Cai Qichun , Pang Clifford L.K. 
Published: March 2022

Abstract
Background: Vitamin C (VitC) has been proposed as a potential anti-cancer agent for prolonging progression-free survival (PFS) and overall survival (OS) in non-small-cell lung cancer (NSCLC) patients. However, VitC has only been shown to be effective for some patients, and the mechanism in those who have benefitted from it remains unknown. We aimed to explore whether gene expression could predict IVC benefit for patients with NSCLC. Methods: H1299 and PC9 cells were treated with VitC and high-throughput sequencing was used for screening differential genes. Data from the Kaplan-Meier Plotter and the Human Protein Atlas databases were used for analysis of patient prognoses. In a retrospective study, 153 NSCLC patients from our Cancer Center were selected and divided into a control group (n = 81) and VitC group (n = 72) for immunohistochemical staining and prognosis analysis. Results: As a result, ZNF507, DLX4, and DDIT4 were found to be upregulated, and SERPINB7, TMEM158 and SERPINE1 downregulated in NSCLC cell lines following VitC treatment. Combined patient data from the cohort analysis and online databases revealed that the downregulated genes, but not upregulated genes, presented an unfavorable prognostic predictor of OS in NSCLC patients. Further analysis showed that the combined three genes were more efficient at predicting survival than individually (AUC=0.77, 95%CI, 0.63-0.90). Moreover, high expression of SERPINB7, TMEM158, and SERPINE1 in resected tumour- tissues before VitC treatment was found to be associated with prolonged OS in patients with NSCLC who were treated with VitC. Conclusion: Overall, these data revealed that SERPINB7, TMEM158, and SERPINE1 formed a novel NSCLC prognosis gene set and could serve as a potential therapeutic target as well as predictive factor for VitC treatment in patients with NSCLC. Trial registration: Retrospectively registered (No: 2/2021-PRE-48) on July 13, 2021.
Prediction of tool wear on workpiece surface quality based on milling topography analysis
Authors: Zhang Wei , Zhang Lei , Zheng Minli , Li Kangning 
Published: March 2022

Abstract
The surface quality of the workpiece has a great impact on the performance of the product. It has always been a key issue of the manufacturing discipline. The different wear levels of cutting tools determine the surface quality of the workpiece. Therefore, the work of this article is to establish a model for calculate the surface quality of the workpiece after milling. First, by defining the tool wear area S and the wear position angle ψ , the cutting edge line model of the tool is determined. Based on the tool motion trajectory and roughness calculation principle, a milling topography simulation roughness model considering tool wear is obtained. Secondly, the tool wear parameters were calibrated with the help of image detection methods, and the predicted values obtained by the model were compared with the experimental values. The law of the influence of the tool wear area S and the wear position angle ψ on the roughness parameters was obtained. Finally, the least squares support vector machine LS-SVM was used to verify the error of the roughness model of the milling topography simulation, and the result showed that the average error of the model was 8.68%.
Closed-form solution of oscillating Maxwell nano-fluid with heat and mass transfer; an application in engine oil
Authors: Farooq Aamir , Alharbi Abdulaziz N. , Rehman Sadique , Kamran Muhammad , Khan Ilyas 
Published: March 2022

Abstract
The primary goal of this article is to analyze the oscillating behavior of Maxwell Nano-fluid with regard to heat and mass transfer. Due to high thermal conductivity engine oil is taken as a base fluid and graphene Nano-particles are introduced in it. Coupled partial differential equations are used to model the governing equations. To evaluate the given differential equations, certain dimensionless factors and Laplace transformations are used. The analytical solution is obtained for temperature, concentration and velocity. The temperature and concentration gradient are also finds to analyze the rate of heat and mass transfer. As a special case, the solution for Newtonian fluid is discussed. Finally, the behaviors of various physical factors are studied graphically for both sine and cosine oscillation and give physical meanings to most of the parameters.
A case of Sheehan syndrome six years postpartum with hypothyroidism and mild hyponatremia
Authors: Jindal Himanshu , Mishra Priya , Khan Efa , Palawat Sandeep Singh 
Published: March 2022

Abstract
Sheehan syndrome, also referred to as postpartum hypopituitarism is often a sequela of massive post-partum hemorrhage in resource poor healthcare settings where blood loss during delivery is often neglected. The diagnosis of this rare but fatal is disease is often delayed because the symptoms are vague and the pituitary dysfunction is insidious in nature. This condition sometimes takes more than a decade before it is diagnosed. The classic signs and symptoms include agalactia, secondary amenorrhea and dry wrinkling skin. Often an empty or a partially empty sella is seen on magnetic resonance imaging of the brain. We present the case of a 35-year-old multiparous female with anhedonia and raised serum transaminases who presented to our side with mild hyponatremia and hypothyroidism. She got diagnosed with Sheehan syndrome at our set up six years after her last obstetric event. Through this case report, we intend to provide a clinical account of the patient’s condition and management.
Developing standardized &amp; interoperable psychiatric discharge summary with role-based user access
Authors: mishra Hara prasad , mishra Smruti sikta 
Published: March 2022

Abstract
Discharge summary is one of the key components of Electronic health records. For mental health patients, the discharge summary serves the dual purpose of communication with primary care and as a future reference within healthcare. Pertaining to the critical sensitivity of the condition and social stigma associated with mental health, people with mental health-related disorders may have health concerns and multiple dilemmas about their post-discharge life. Currently, in many cases, like for insurance purposes, post-discharge care, and medications, the patient has to share the complete discharge summary despite the fact that the document owner might not need the complete discharge summary with all components. We addressed this problem by developing a standardized & interoperable psychiatric discharge summary with role-based access. The discharge summary is based on FHIR standards so as to ensure standardized data sharing and integration. The discharge summary is thus divided into multiple components based on FHIR standards and sensitivity of the medical records and information. The built in feature of role based access will ensure that patients share only that component of the discharge summary which they require.
Optimal duration of antibiotics therapy after Video-assisted thoracoscopic surgery in thoracic empyema and complicated parapneumonic effusion
Authors: Yukumi Shungo , Ishimaru Kei , Suzuki Hideaki , Abe Masahiro , Morimoto Masamitsu , Senba Mayuko , Yamamoto Tetsuya , Mori Yu , Sakao Nobuhiko , Sano Yoshifumi 
Published: March 2022

Abstract
Background
There is no evidential report about the optimal duration of antibiotics use following Video-assisted thoracoscopic surgery debridement (VATS-D) in thoracic empyema (TE) or complicated parapneumonic effusion (PPE). The purpose of this study was to determine the optimal duration of antibiotics therapy after VATS-D for TE /PPE.
Methods
Between January 2011 and December 2019, total thirty-three patients (28 men, 5 women; median age 63 years) corresponding to ACCP category 3 or 4 recieving VATS-D were included in the study. Time until the body temperature (BT) confirmed to be less than 37.5 ºC and 37.0ºC, WBC to be less than10,000/µl, segmented neutrophil (seg) to be less than 80% were retrospectively analyzed.
Results
Median time from the onset of TE/PPE to operation was 13 days. Pre and postoperative antibiotics use were 5 and 7 days in median value. There was no hospital death within 30 days from the operation. Major complication occurred in 4 cases (3 respiratory failures and one cerebral infarction). Median postoperative hospital stay was 14 days. Success rate in TE/PPE treatment was 88%. The median number of days until the conditions met were BT > 37.5 ºC for 3 days, BT > 37.0 ºC for 6 days, WBC < 10,000 for 4 and seg < 80% for 7 days.
Conclusion
Optimal antibiotics duration of antibiotics use after VATS-D for TE/PPE is about 5 days. Urgent VATS-D will shorten the total antibiotics duration.
Trace element partitioning between anhydrite, sulfate melt, and silicate melt
Authors: Hutchinson Michael C. , Brooker Richard A. , Blundy Jon D. , Dilles John H. , Lewis Charles T. 
Published: March 2022

AbstractAnhydrite has become increasingly recognized as a primary igneous phase since its discovery in pumices from the 1982 eruption of El Chichón, Mexico. Recent work has provided evidence that immiscible sulfate melts may also be present in high-temperature, sulfur-rich, arc magmas. In this study we present partition coefficients for 37 trace elements between anhydrite, sulfate melt and silicate melt based on experiments at 0.2–1 GPa, 800–1200 °C, and fO2 &gt; NNO+2.5.Sulfate melt–silicate melt partition coefficients are shown to vary consistently with ionic potential (the ratio of nominal charge to ionic radius, Z/r) and show peaks in compatibility close to the ionic potential of Ca and S. Partition coefficients for many elements, particularly REE, are more than an order of magnitude lower than previously published data, likely related to differences in silicate melt composition between the studies. Several highly charged cations, including V, W, and Mo are somewhat compatible in sulfate melt but are strongly incompatible in anhydrite. Their concentrations in quench material from natural samples may help to fingerprint the original presence of sulfate melt.Partition coefficients for 2+ and 3+ cations between anhydrite and silicate melt vary primarily as a function of the calcium partition coefficients (DCaAnh−Sil) and can be described in terms of exchange reactions involving the Ca2+ site in anhydrite. Trivalent cations are dominantly charge-balanced by Na1+. Most data are well fit using a simple lattice-strain model, although some features of the partitioning data, including DLaAnh−Sil&gt;DCeAnh−Sil, suggest the occurrence of two distinct anhydrite Ca-sites with slightly different optimum radii at the experimental conditions.The ratio DSrAnh−Sil&gt;DCaAnh−Sil is shown to be relatively insensitive to silicate melt composition and should vary from 0.63–0.53 between 1200–800 °C, based on a simple, “one-site” lattice strain model. Comparison to DSrAnh−Sil and DCaAnh−Sil calculated for natural anhydrite suggests that in most cases, including the S-rich eruptions of Pinatubo and El Chichón, the composition of anhydrite is consistent with early crystallization of anhydrite close to the liquidus of silicate melt with a composition approximately that of the bulk erupted material. This illustrates how anhydrite (and perhaps sulfate melt) provides a mechanism to transport large quantities of sulfur from significant depth to the eruptive environment.
Occurrence and toxicological assessment of selected active pharmaceutical ingredients in effluents of pharmaceutical manufacturing plants and wastewater treatment plants in Kampala, Uganda
Authors: Kayiwa R. , Kasedde H. , Lubwama M. , Kirabira J. B. , Kayondo Timothy 
Published: March 2022

Abstract
There is an increasing eco-toxicological risk associated with pharmaceuticals globally. The prevalence of six active pharmaceutical ingredients (APIs) was studied in effluents of three pharmaceutical manufacturing plants (PMPs) and two wastewater treatment plants (WWTPs) in Kampala, Uganda to ascertain the removal potentials for APIs. The APIs include atenolol, losartan, carbamazepine, sulfamethoxazole, clarithromycin, and diclofenac. The APIs were extracted using solid-phase extraction cartridges and concentrations were analyzed using a liquid chromatography-mass spectrometer system. The concentration ranges of the APIs were &lt;limit of detection (LOD), &lt;LOD – 4.75, &lt;LOD – 1.37, &lt;LOD – 1.17, and 0.28–19.55 mgL−1 for losartan, diclofenac, sulfamethoxazole, carbamazepine, and clarithromycin respectively in effluents of WWTPs, whereas in treated wastewater from PMPs concentrations were 0.00, 0.00–0.23, 5.30–7.4, 0.00–0.14, and 0.12–4.53 mgL−1 for losartan, diclofenac, sulfamethoxazole, carbamazepine, and clarithromycin respectively. The API removal efficiency of PMPs was higher than WWTPs with some APIs removed to concentrations of &lt;LOD. The range of hazard quotients (HQs) for APIs was 0.018–0.9775000 with most of the APIs posing remarkably high environmental risks at HQs way greater than 1. Only sulfamethoxazole from the effluents of Lubigi WWTP, Bugolobi WWTP, and PMP C posed low risks with HQs of &lt;1 at 0.018, 0.305, and 0.018 respectively. The high HQs for most APIs imply that immediate recipients are at very high toxicological risks, yet most studies have focused on the final destinations of APIs in environments where toxicological risks are often minimal due to dilution effects.
The ATP-dependent Pathways and Human Diseases
Authors: Suwara Justyna , Radzikowska-Cieciura Ewa , Chworos Arkadiusz , Pawlowska Roza 
Published: March 2022

Abstract:
Adenosine triphosphate (ATP) is one of the most important molecules of life,
present both inside the cells and extracellularly. It is an essential building block for nucleic
acids biosynthesis and crucial intracellular energy storage. However, one of the most
interesting functions of ATP is the role of a signaling molecule. Numerous studies indicate
the involvement of ATP-dependent pathways in maintaining the proper functioning
of individual tissues and organs. Herein, the latest data indicating the ATP function in the
network of intra- and extracellular signaling pathways including purinergic signaling,
MAP kinase pathway, mTOR and calcium signaling are collected. The main ATP-dependent
processes maintaining the proper functioning of the nervous, cardiovascular and immune
systems, as well as skin and bones, are summarized. The disturbances in the ATP
amount, its cellular localization, or interaction with target elements may induce pathological
changes in signaling pathways leading to the development of serious diseases. The impact
of an ATP imbalance on the development of dangerous health dysfunctions such as
neurodegeneration diseases, cardiovascular diseases (CVDs), diabetes mellitus, obesity,
cancers and immune pathogenesis are discussed here.
Comparison of Diagnostic Accuracies of USG, MG and MRI Modalities
Defined with BI-RADS Classification System
Authors: Serinsöz Serdar , Akturk Remzi 
Published: March 2022

Background:
BI-RADS classification provides facilitating information in diagnosis for radiologists. It allows radiologists to interpret mammograms accurately

Objective:
We aimed to compare the diagnostic accuracy of the modalities with the BI-RADS classification system made with imaging findings accompanied by USG, MG and MRI, which are a total of 3 modalities.

Methods:
This study included 82 patients who underwent Tru-Cut biopsy under the guidance of USG, MG, and MRI. Mammography, sonography and MRI were performed in the prone position.

Results:
Of the patients, 46.3%, 14.6%, and 39.0% were assessed in 4A, 4B, and 5 MRI BI-RADS categories, respectively. Based on the variable surgical/pathological diagnosis, 50%, 28.0%, and 22.0% of the patients were categorized as malignant findings, benign findings, and infection-inflammation-mastitis, respectively. The determination of the endpoints for the parameter of long-axis diameter (mm) was found to be statistically significant according to ROC analysis as a gold standard performed based on specificity levels of benign and malignant findings (p<0.05). A significant correlation was detected between the gold standard and the categorical variable MRI BI-RADS (χ^2=46.380, p<0.01).

Conclusion:
When specificity and sensitivity of all three modalities in surgical/pathological diagnosis were compared, it was concluded that MRI was superior to the other modalities, and a valuable method in prediction of lesion malignancy and determination of biopsy prediction and priority.