bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of probiotics for regulation of inflammatory response in radiation-induced enteritis
Authors: Lee Sung Uk , Jang Bum-Sup , Na Yi Rang , Lee Sun Hwa , Han Sunwoo , Chang Ji Hyun , Kim Hak Jae 
Published: November 2022

Abstract
Purpose: Cancer patients who receive radiation therapy (RT) in the abdominopelvic area often experience radiation enteritis. The purpose of this study was to investigate the role of probiotics in radiation enteritis using in vivo mice.
Methods: A total of 40 mice were randomly assigned to four groups: control, probiotics, RT, and RT + probiotics. For the group of probiotics, 0.2 mL of solution that contained 1.0 × 108 colony-forming units (CFU) of Lactobacillus rhamnosus GG (LGG) was used and orally administered daily until sacrifice. For RT, a single dose of 14 Gy was administered using a 6 mega-voltage photon beam to the abdominopelvic area. Mice were sacrifice at day 4 (S1) and day 7 (S2) after RT. Their jejunum, colon, and stool were collected. A multiplex cytokine assay and 16s ribosomal RNA amplicon sequencing were then performed.
Results: Regarding cytokine concentrations in tissues, pro-inflammatory cytokines TNF, IL-6, and MCP-1 showed decreased protein levels in colon tissues of the RT + probiotics group than in the RT group. The abundance of microbes showed no significant difference between RT + probiotics and RT groups except increased alpha-diversity in the stool at S2 of the RT + probiotics group. Probiotics-related and anti-inflammation-related microbes were dominant in the jejunum, colon, and stool from early days after administration of probiotics (probiotics or RT + probiotics groups). Differentially predicted metabolic pathways associated with anti-inflammatory process were found in the RT + probiotics group compared to the RT alone group.
Conclusion: Protective effects of probiotics on radiation enteritis were potentially derived from dominant anti-inflammation-related microbes and metabolites.
Phylogenetic systematics of Butyrivibrio and Pseudobutyrivibrio pure culture and metagenomically assembled genomes suggest existence of 59 genera and 75 species, alongside possession of open pangenomes with an abundance of carbohydrate-active enzyme family isoforms
Authors: Pidcock Sara E. , Skvortsov Timofey , Courtney Stephen J. , Creevey Christopher J. , Huws Sharon A. 
Published: November 2022

Abstract
Background
Gut microbiomes are crucial for host nutrition due to their feed energy-harvesting capacity. In the rumen microbiome Butyrivibrio and Pseudobutyrivibrio dominate and play a key role in harvesting dietary energy. Within these genera, five rumen species have been classified (Butyrivibrio fibrisolvens, B. hungatei, B. proteoclasticus, Pseudobutyrivibrio ruminis and P. xylanivorans) and more recently an additional sixth Butyrivibrio sp. group was added. Nonetheless, in recent years the explosion in available metagenomically assembled genomes (MAGs) offer a new insight into their taxonomy and function. Consequently, in this study we analysed the pangenome and function of 64 MAGs and 71 culture representatives of Butyrivibrio and Pseudobutyrivibrio.
Results
Using MASH and ANI we demonstrate that the 135 Butyrivibrio and Pseudobutyrivibrio genomes from MAGs and pure culture cluster into 59 genera and 75 species. Pangenome analysis of 8 groups containing > 4 strains showed average core genome percentages of between 38.49–76.67%. In turn, the accessory genome percentages for the 8 groups were between 23.33% and 65.39%. The most abundant GH families found in the 8 groups were GH13, GH3, GH43, GH2, GH25, GH31, GH36, and GH5 in descending order. Dendograms of the GH families show extensive variation, and expression of 20.45–47.11% of the genes is observed in metatranscriptome datasets.
Conclusions
Our findings demonstrate that Butyrivibrio and Pseudobutyrivibrio genomes cluster into 59 genera and 75 species. The 8 groups containing 4 or more genomes that were carried forward possess open genomes with extensive genomic diversity. The MAGs, alongside genomes for cultured isolates, contained an expansive repertoire of glycosyl hydrolase isoforms, which likely facilitate the symbiotic breakdown of plant matter under dietary perturbations allowing a competitive advantage and driving niche specialisation. This study has enabled a substantial enhancement in our understanding of the functional capacity and taxonomy of the dominant rumen isolates, Butyrivibrio and Pseudobutyrivibrio by utilising all recently published rumen MAGs.
The press-assisted fusion scheme greatly reduces the amount of HVJ-E required in mitochondrial replacement techniques
Authors: Ma Meng , Jiang Shutian , Jin Wei , Li Wenzhi , Chen Chen , Lin Kaibo , Liao Xiaoyu , Li Danjun , Kuang Yanping , Lyu Qifeng 
Published: November 2022

Abstract
Background
Mitochondrial replacement techniques (MRTs) afford pathogenic mitochondria carried women an opportunity to have related disease-free offspring with a genetic link. Among the fusion methods, HVJ-E-induced fusion has been considered the most promising method for MRTs clinical translation. Although HVJ-E has been confirmed to have no RNA activity, a decrease in blastocyst quality was observed in several MRTs studies with HVJ-E-induced fusion scheme. Nevertheless, HVJ-E has not been proven to be a single factor affecting embryonic development in MRTs. Safety has been the biggest obstacle for its clinical application.
Methods
Pronuclear transfer (PNT) was performed on mouse zygotes and human abnormal zygotes (3PN,1PN) with the traditional HVJ-E-induced fusion (original HVJ-E) and press-assisted HVJ-E-induced fusion (1%HVJ-E). Fusion rates and residual amount of HVJ-E (the relative HVJ-E fluorescence intensity) in reconstructed mouse and human zygotes were assessed. Cleavage rate, blastocyst formation rate, intracellular ROS levels and double-stranded DNA breaks (γH2A.X) of reconstructed mouse zygotes in traditional fusion and press-assisted fusion groups were assessed.
Results
No significant differences were observed in the fusion rates of the press-assisted fusion and traditional fusion group in mouse zygotes and human 3PN/1PN zygote. The relative HVJ-E fluorescence intensity of the press-assisted fusion group was greatly lower than traditional fusion group in mouse and human. The relative ROS fluorescence intensity and the γH2A.X loci of the press-assisted fusion group were lower than that in the traditional group. The blastocyst formation rates in the press-assisted fusion were higher than hat in the traditional fusion group.
Conclusions
In this study, we proved high concentration of HVJ-E used in traditional HVJ-E fusion scheme is an independent factor affecting embryonic development in MRTs, which might be caused by enhanced DNA damage due to increased ROS levels in reconstructed embryos. In order to minimize the amount of HVJ-E attached to the reconstructed zygotes without reducing the fusion efficiency in MRTs, we designed a new scheme for HVJ-E-induced fusion: the press-assisted fusion, which is beneficial to decrease the adverse factors affecting embryo development in MRTs.
Surgery for Locally Advanced Gastric Cancer in the Era of Neo-adjuvant Therapies: something new?
Authors: Rosa Fausto , Tondolo Vincenzo , Schena Carlo Alberto , Laterza Vito , Strippoli Antonia , Covino Marcello , Pacini Giovanni , Quero Giuseppe , Fiorillo Claudio , Tortora Giampaolo , Alfieri Sergio 
Published: November 2022

Abstract
Purpose: Locally advanced gastric cancer (LAGC) represents a therapeutic challenge. The aim of this study was to analyze prognostic factors influencing survival and surgical strategies and possible influence of neoadjuvant chemotherapy over a ten-years experience in a tertiary Western center.
Methods: Between January 2010 and December 2020, the medical records of 113 patients with LAGC who underwent curative resection were retrospectively reviewed. Patient characteristics, related complications, long-term survival, and prognostic factors were analyzed at uni- and multivariate analyses.
Results: Multivariate analysis revealed that neoadjuvant therapy, completeness of resection (R0), number of lymph nodes retrieved, N status and the adoption of HIPEC were independent prognostic factors associated with longer survival.
Five-year overall survival for NAC group and upfront surgery group was 46% and 32%, respectively (p=0.04).
Five-year disease-free survival for NAC group and upfront surgery group was 38% and 25%, respectively (p=0.02).
Conclusion: Patients with LAGC undergoing surgery plus neoadjuvant therapy had a better OS and DFS respect to patients undergoing upfront surgery. No difference was observed in terms of surgical strategy.
Thermodynamic properties and critical behavior of spin-polarized atomic hydrogen (H↓) using the quantum second virial coefficient
Authors: Joudeh Bassam R. 
Published: November 2022

Abstract
The quantum-mechanical formulations for the second virial, and the acoustic virial, coefficients are derived for spin-polarized atomic hydrogen (H↓). The dependence of these coefficients on the temperature T as well as the nuclear polarization ζ is analyzed. This is done for the first time. The main inputs in these computations are the scattering phase shifts, which are obtained using the Lippmann-Schwinger equation, with the Silvera triplet-state potential.
Starting with these phase shifts, comprehensive calculations of the thermophysical properties for this system are performed for T ranging from 1µK to 100 K, and ζ varying from 0 to 1. These properties include, in addition to the quantum second virial coefficient and the acoustic virial coefficient: the pressure-polarization-temperature (P-ζ-T) behavior, the entropy (per atom), the speed of sound, the second virial correction (to the total internal energy per atom and unit density), and the specific heat capacity (per atom and unit density). The Boyle temperature and the Joule inversion temperature are determined. The T-dependence of these thermophysical properties, and related quantities, is explored. As expected, this dependence is most evident in the low-T limit, where quantum effects predominate. The corresponding ζ-dependence becomes noticeable at 80 K and below. It is observed that the virial coefficients tend to decrease with increasing ζ. Comparison of the present results to previous results are included whenever possible. The overall agreement is very good.
As T is lowered, the disruptive effects of thermal energy are weakened relative to the attractive interactions between the atoms. Consequently, the H↓ gas makes a transition to a state of higher order and lower entropy – Bose-Einstein condensation (BEC). This is explored carefully.
Valve disease in cardiac amyloidosis: an echocardiographic score
Authors: Aimo Alberto , Fabiani Iacopo , Maccarana Agnese , Vergaro Giuseppe , Chubuchny Vladyslav , Pasanisi Emilio , Petersen Christina , Poggianti Elisa , Giannoni Alberto , Spini Valentina , Taddei Claudia , Castiglione Vincenzo , Passino Claudio , Fontana Marianna , Venneri Lucia 
Published: November 2022

Abstract
Background
Cardiac amyloidosis (CA) may affect all cardiac structures, including the valves.
Methods
From 423 patients undergoing a diagnostic workup for CA we selected 2 samples of 20 patients with amyloid transthyretin (ATTR-) or light-chain (AL-) CA, and age- and sex-matched controls. We chose 31 echocardiographic items related to the mitral, aortic and tricuspid valves, giving a value of 1 to each abnormal item.
Results
Patients with ATTR-CA displayed more often a shortened/hidden and restricted posterior mitral valve leaflet (PMVL), thickened mitral chordae tendineae and aortic stenosis than those with AL-CA, and less frequent PMVL calcification than matched controls. Score values were 15.8 (13.6–17.4) in ATTR-CA, 11.0 (9.3–14.9) in AL-CA, 12.8 (11.1–14.4) in ATTR-CA controls, and 11.0 (9.1–13.0) in AL-CA controls (p = 0.004 for ATTR- vs. AL-CA, 0.009 for ATTR-CA vs. their controls, and 0.461 for AL-CA vs. controls). Area under the curve values to diagnose ATTR-CA were 0.782 in patients with ATTR-CA or matched controls, and 0.773 in patients with LV hypertrophy.
Conclusions
Patients with ATTR-CA have a prominent impairment of mitral valve structure and function, and higher score values. The valve score is quite effective in identifying patients with ATTR-CA among patients with CA or unexplained hypertrophy.
Fast Simulation for the Super Charm-Tau Factory Detector
Authors: Barnyakov Alexander , Belozyorova Maria , Bobrovnikov Victor , Kononov Sergey , Kyshtymov Dmitriy , Maksimov Dmitry , Razuvaev Georgiy , Sukharev Andrey , Todyshev Korneliy , Vorobyev Vitaliy , Zhadan Anastasiia , Zhadan Daniil 
Published: November 2022

Abstract
The Super Charm-Tau factory (high luminosity electron-positron collider with 3-7 GeV centre mass energy range) experiment project is under development by the consortium of Russian scientific and education organisations. The article describes the present status of the Super-Charm Tau detector fast simulation and algorithms it is based on, shows some usage recipes, and demonstrates first simulation results.
Bifurcation of Limit Cycles and Isochronous Centers on Center Manifolds for a Class of Cubic Kolmogorov Systems in R3
Authors: Gu Jieping , Zegeling Andr´e , Huang Wentao 
Published: November 2022

Abstract
Our work is concerned with the number of limit cycles and isochronous center conditions for a class of three-dimensional cubic Kolmogorov systems with an equilibrium point in the positive octant where the system has biological meaning. A formal series method of computing singular point values (equivalent to focal values) is applied to investigate the Hopf bifurcation and center problem on center manifolds for the Kolmogorov system. Using this we derive two sets of conditions for the equilibrium point to be a center on a center manifold for the system, and prove that at most seven small-amplitude limit cycles can be bifurcated from an isolated positive equilibrium point. We prove that seven limit cycles can be created in this way, obtaining a new result on the number of limit cycles in three-dimensional cubic Kolmogorov systems. Moreover, two sets of necessary conditions for the existence of an isochronous center on the center manifold for such systems are obtained by the computation of period constants. The Darboux theory of linearizability is applied to show the sufficiency of the conditions.
Mathematics Subject Classification (2010). 34C05, 34C07.
Critical Care Nurses’ Perceptions of Enteral Nutrition: A Descriptive Cross-Sectional Study
Authors: Al-Sayaghi Khaled Mohammed , Alqalah Talal Ali Hussein Saad , Alkubati Sameer Abdulmalik , Alrubaiee Gamil Ghaleb , Alshoabi Sultan Abdulwadoud , Atrous Masouda Hassan , Mohamed Farida Khalil Ibrahim , Alsultan Kamal Dahan , Suliman Awadia Greeballah , Gameraddin Moawia Bushra , Fadlalmola Hammad Ali , Alwesabi Sadeq Abdo Mohammed , Alsabri Mohammed 
Published: November 2022

Background and Objective:
Nutritional support is an essential component of critical care with a significant effect on the outcomes of critically ill patients. Critical care nurses are in a central position to achieve nutritional goals and preserve the nutritional status of patients at best. This study aimed to investigate the critical care nurses’ perceptions of the responsibility, knowledge, and documentation system support regarding enteral nutrition.

Methods:
Data were collected from 292 critical care nurses in different healthcare sectors in Sana’a, the capital of Yemen, using a quantitative, descriptive, cross-sectional design. A self-administered questionnaire containing 50 items was used for data collection. The data were collected between March and June 2021. The Statistical Package for the Social Sciences (SPSS) version 16 was used for the data analysis.

Results:
The study found that most critical care units did not have guidelines, protocols, or a nutritional support team, and the physicians prescribed enteral nutrition. The critical care nurses perceived they had a low responsibility, insufficient knowledge, and moderate documentation support regarding enteral nutrition. The nurses in private hospitals had the highest responsibility, the nurses who received in-service education about enteral nutrition reported the highest level of knowledge, and the nurses in the Neuro critical care units had the best support from a documentation system. Scientific workshops and conferences were the main sources of knowledge regarding enteral nutrition. The nurses’ educational needs included the ability to evaluate the outcomes, goal setting, and nutritional assessment.

Conclusions:
The critical care nurses perceived a low responsibility, low level of knowledge, and moderate support from a documentation system regarding enteral nutrition. There is an urgent need to create or adopt enteral nutrition evidence-based guidelines and protocols and establish a multidisciplinary nutritional support team with clear roles and responsibilities. In-service education and training related to enteral nutrition are paramount.
Review on Terahertz Metamaterial Absorbers
Authors: Jia Haoduo , Tang Xin , Li Ming , Wu Dai , Li Peng , Wang Jianxin , Zhu Xinghua , Yang Dingyu 
Published: November 2022

Abstract:
Absorbers are devices that internally consume electromagnetic waves to partially or
completely attenuate them. The basic idea is to absorb electromagnetic radiation by resonating the
intended surface with the incident electromagnetic waves. This article focuses on the development
of the absorber (from single-band to multi-band, narrow to broadband, non-tunable to tunable, and
so on). The basic absorption principle of the current popular and excellent metamaterial graphene
absorber is provided, as is the theoretical explanation of impedance matching and how to attain critical performance metrics like tunability, as well as prospects for terahertz (THz) absorber applications. Finally, numerous innovative absorbers are shown as examples, providing new ideas for future researchers.
Efectos de amitraz más Parapoxvirus ovis sobre EGF, VEGF, IGF-1 e IGF-2 en la demodicosis generalizada canina
Authors: Yarim Gul Fatma , Pekmezci Didem , Yarim Murat , Bekir Yagci Bugrahan , Gokceoglu Ayris , Sozmen Mahmut , Zafer Pekmezci Gokmen , Karaca Efe , Guzel Murat 
Published: November 2022

Objective. The purpose of the study is to investigate the effect of treatment with amitraz plus-Parapoxvirus ovis (IPPVO) on serum concentrations and skin expressions of insulin-like growth factor (IGF)-1 and -2, epidermal growth factor (EGF), vascular endothelial growth factor (VEGF), in dogs suffering from generalised demodicosis (GD). Materials and Methods. Generalised demodicosis affected dogs were injected 1 ml IPPVO on days 0, 2 and 9 subcutaneously in addition to amitraz (0.025 %) treatment twice weekly for 80 days. IGF-1, IGF-2, EGF and VEGF concentrations in blood serum were measured by canine-specific enzyme-linked immunosorbent assay kit. EGF, VEGF, IGF-1, and IGF-2 expressions in skin biopsy specimens were examined immunohistochemically. Results. After the treatment of the dogs with amitraz plus-IPPVO in GD, we demonstrated a significant reduction in both circulating concentrations and skin expressions of EGF, VEGF, IGF-1, and IGF-2, which have a role in preserving skin integrity and wound healing. Conclusions. Results of this study suggest that IGF-1, IGF-2 EGF, and VEGF have a crucial role in the progression of GD in dogs. It is believed that the findings from this study will contribute to the development of new strategies for the treatment of GD, which is an important health problem for dogs.
Exclusión, excepción y violencia hacia los migrantes centroamericanos
Authors: Morales Vargas María José , Pastén Palma Claudio Aquiles 
Published: November 2022

Violence, exclusion, and exception faced by migrants when crossing the Mexican border are analyzed from critical theory and a regional perspective. Following Michael Foucault’s pathway and his core concept biopolitics, contemporary theoreticians are chosen from the critical current to analyze extreme daily violence undocumented subjects suffer during their journey. This journey starts in their home countries, continuing through Mexico, the country of transit. It is argued that a migrant’s body appears as the “nuda vida” (naked life) of a mere body or man who can be killed in exception zones, with nobody being punished for it.
Node Localization in Wireless Sensor Networks using Dynamic Genetic Algorithm
Authors: Rout Saroja Kumar , Mohapatra Pradyumna Kumar , Rath Amiya Kumar , Sahu Bibhuprasad 
Published: November 2022

A wireless sensor network is a collection of nodes organized in a cooperative environment. Node localization plays a vital role in many applications. Conventional location detection techniques such as global positioning system (GPS) and infrared are expensive to find the location node. This paper proposes the use of a genetic algorithm (GA) to learn the environment impairments within a wireless sensor network with the purpose of localization for data management. Hence, in this paper, we have presented an efficient and dynamic Genetic algorithm with help of receiving signal strength indicator (RSSI) which gives the optimal node location value with minimal localization error. Our simulation modeled in MATLAB 7.0 shows that the dynamic GA can achieve acceptable node location detection with the aid of three anchors. The simulation results represent th
Pengaruh audit tenure, reputasi auditor, komite audit dan fee audit terhadap kualitas audit (studi empiris pada perusahaan yang terdaftar di indeks Kompas100 pada BEI Tahun 2012-2016)
Authors: Rizaldi Sendy , Rahayu Sri , Tiswiyanti Wiwik 
Published: November 2022

This study examines the influence of audit tenure, auditors' reputation, audit committees, and audit fees on audit quality. Audit quality uses current proxy accruals; while the term is measured by counting the year in which the same auditors have made an engagement with the auditee, the reputation of the auditor is measured by a dummy variable using the big four and non-big four groups of auditors, the audit committee is measured by the percentage amount of the audit committee comparing to the number of commissioners and audit fee measured by professional fees account on the financial statement. The population in this study consists of listed go public firm KOMPAS100 index on Indonesia Stock Exchange in the year 2012-2016. The sampling method used is purposive sampling. The sample's total is 135 from 27 firms over five years of research in this research—multiple regression analysis used to be the analysis technique. The empirical result of this study shows that audit tenure and reputation of the auditor had not significantly influenced audit quality. Meanwhile, the audit committee and audit fee variable positively affect the audit quality.
Analyzing Eight Emerging Topics and Their Importance to Career Success
Authors: Harrast Steven A. , Olsen Lori , Sun Yan 
Published: November 2022

ABSTRACT
The inclusion of eight emerging topics on future Certified Public Accounting (CPA) exams challenges educators to prioritize these topics in the accounting curriculum. We analyze the emerging topics and discuss their importance and appropriate teaching locus in light of survey evidence collected from professionals. The results support the preeminence of data analytics above other emerging accounting topics and show the relative importance of other topics based on their statistically significant differences. The results are helpful as educators make decisions about where to teach particular topics as well as their relative emphasis. To augment the analysis, we also examine factors that influence professionals’ judgement of the importance of data analytics to career success and find a positive relationship between years of experience and data analytics importance.