bluuebunny/crossref_metadata_2025_split huggingface dataset:
Modelling and simulation of extreme wave heights around agatti island of lakshadweep, west coast of India
Authors: Dinakaran Shyamala Varthini , Alluri Kiran Raju , Joseph K Jossia , Murthy M V Ramana , Venkatesan Ramasamy 
Published: October 2022

Small islands experience variation in wave energy regime along shorter shoreline due to refraction, diffraction and variability in direction of wave travel. Nearshore wave climate around these islands is quite complex due to wave transformation associated with configuration of islands, and high steepness in the bathymetry. Understanding wave energy will help in identifying suitable locations for coastal structures, wave energy devices and sediment budgeting. Assessment of extreme wave climate around the islands play a crucial role in the design and survival of coastal infrastructure for any developmental activities in islands. This study investigates the extreme wave climate around the Agatti island of Union Territory of Lakshadweep located in west coast of India. The spatial variability of wave power distribution around the Agatti island is analyzed based on 10 years of wave hindcast data from spectral wave modelling for the period between 2011 and 2020 using spectral wave model. In this study, third-generation spectral wave model was used to simulate the wave climate over the Arabian Sea. Regional model was established using ECMWF model winds and the offshore wave parameters were validated with deep water ocean observations AD07 and AD09 deployed in the Arabian Sea. To understand the nearshore wave transformation along the Agatti island, local wave model of fine resolution was established using high resolution bathymetry and is validated using the coastal buoy (CB02) deployed near Agatti. Nearshore wave parameters such as Significant wave height, Peak wave period (Tp) and Mean wave direction (θm) were analyzed. The wave power distribution around the island was quantified and demarcated for siting of offshore structures for developmental activities. The study reveals that the south zone of the island is more energetic with annual mean wave power of 8–12 kW/m and during monsoon, wave power more than 28 kW/m is observed. The extreme value theory based on Generalized Extreme Value distribution is applied to the extreme wave height estimate based on modelled wave data around the Agatti island. The extreme wave heights for different return periods were estimated around the Agatti island for design and analysis of coastal infrastructure.
Limitation of room temperature phosphorescence efficiency in metal organic frameworks due to triplet-triplet annihilation
Authors: Zhao Tonghan , Busko Dmitry , Richards Bryce S. , Howard Ian A. 
Published: October 2022

The effect of triplet-triplet annihilation (TTA) on the room-temperature phosphorescence (RTP) in metal-organic frameworks (MOFs) is studied in benchmark RTP MOFs based on Zn metal centers and isophthalic or terephthalic acid linkers (ZnIPA and ZnTPA). The ratio of RTP to singlet fluorescence is observed to decrease with increasing excitation power density. Explicitly, in ZnIPA the ratio of the RTP to fluorescence is 0.58 at 1.04 mW cm−2, but only 0.42 at (the still modest) 52.6 mW cm−2. The decrease in ratio is due to the reduction of RTP efficiency at higher excitation due to TTA. The density of triplet states increases at higher excitation power densities, allowing triplets to diffuse far enough during their long lifetime to meet another triplet and annihilate. On the other hand, the shorter-lived singlet species can never meet an annihilate. Therefore, the singlet fluorescence scales linearly with excitation power density whereas the RTP scales sub-linearly. Equivalently, the efficiency of fluorescence is unaffected by excitation power density but the efficiency of RTP is significantly reduced at higher excitation power density due to TTA. Interestingly, in time-resolved measurements, the fraction of fast decay increases but the lifetime of long tail of the RTP remains unaffected by excitation power density. This may be due to the confinement of triplets to individual grains, leading decay to be faster until there is only one triplet per grain left. Subsequently, the remaining “lone triplets” decay with the unchanging rate expressed by the long tail. These results increase the understanding of RTP in MOFs by explicitly showing the importance of TTA in determining the (excitation power density dependent) efficiency of RTP. Also, for applications in optical sensing, these results suggest that a method based on long tail lifetime of the RTP is preferable to a ratiometric approach as the former will not be affected by variation in excitation power density whereas the latter will be.
Catalytic dye degradation by novel phytofabricated silver/zinc oxide composites
Authors: Bloch Khalida , Mohammed Shahansha M. , Karmakar Srikanta , Shukla Satyajit , Asok Adersh , Banerjee Kaushik , Patil-Sawant Reshma , Mohd Kaus Noor Haida , Thongmee Sirikanjana , Ghosh Sougata 
Published: October 2022

Phytofabrication of the nanoparticles with exotic shape and size is an attractive area where nanostructures with noteworthy physicochemical and optoelectronic properties that can be significantly employed for photocatalytic dye degradation. In this study a medicinal plant, Plumbago auriculata leaf extract (PALE) was used to synthesize zinc oxide particles (ZnOPs) and silver mixed zinc oxide particles (ZnOAg1Ps, ZnOAg10Ps, ZnO10Ag1Ps) by varying the concentration of the metal precursor salts, i.e. zinc acetate and silver nitrate. The PALE showed significantly high concentrations of polyphenols, flavonoids, reducing sugar, starch, citric acid and plumbagin up to 314.3 ± 0.33, 960.0 ± 2.88, 121.3 ± 4.60, 150.3 ± 3.17, 109.4 ± 2.36, and 260.4 ± 8.90 μg/ml, respectively which might play an important role for green synthesis and capping of the phytogenic nanoparticles. The resulting particles were polydispersed which were mostly irregular, spherical, hexagonal and rod like in shape. The pristine ZnOPs exhibited a UV absorption band at 352 nm which shifted around 370 in the Ag mixed ZnOPs with concomitant appearance of peaks at 560 and 635 nm in ZnO10Ag1Ps and ZnOAg1Ps, respectively. The majority of the ZnOPs, ZnOAg1Ps, ZnOAg10Ps, and ZnO10Ag1Ps were 407, 98, 231, and 90 nm in size, respectively. Energy dispersive spectra confirmed the elemental composition of the particles while Fourier transform infrared spectra showed the involvement of the peptide and methyl functional groups in the synthesis and capping of the particles. The composites exhibited superior photocatalytic degradation of methylene blue dye, maximum being 95.7% by the ZnOAg10Ps with a rate constant of 0.0463 s−1 following a first order kinetic model. The present result clearly highlights that Ag mixed ZnOPs synthesized using Plumbago auriculata leaf extract (PALE) can play a critical role in removal of hazardous dyes from effluents of textile and dye industries. Further expanding the application of these phytofabricated composites will promote a significant complementary and alternative strategy for treating refractory pollutants from wastewater.
Technical success, clinical efficacy, and insight into the causes of restenosis after the percutaneous coronary intervention of de novo coronary artery lesions using a paclitaxel-coated balloon with citrate ester excipient
Authors: Tervo Jerry , Kärkkäinen Jussi M. , Rissanen Tuomas T. 
Published: October 2022

ObjectivesThe aim of this all-comers registry study was to investigate the technical success, clinical efficacy, and safety of a drug-coated balloon (DCB) with paclitaxel combined with citrate ester excipient (CEE) in percutaneous coronary intervention (PCI) of de novo coronary lesions in an all-comers population.Materials and methodsA total of 338 consecutive PCIs using the DCB (CEE)-only approach comprising 406 de novo lesions were included in the study. Technical success was determined by the successful delivery of the device and no need for bailout stenting.ResultsThe mean follow-up time was 25 ± 12 months. The mean age of patients was 71 ± 11 years, and 48% had the acute coronary syndrome. A total of 55% of the patients were at risk of factor bleeding. The delivery of DCB was successful in 98% of cases. The overall technical success rate was 83%. Bailout stenting was used in 9% of lesions. Rotational atherectomy was used in 11% of cases before the DCB-only approach. The mean diameter of the DCBs used was 2.7 ± 0.5 mm and 38% of DCBs were large (≥3.0 mm). The 12-month MACE rates were 5.4 ± 1.7 and 18.3 ± 3.1% in stable CAD and in ACS, respectively. The respective target lesion revascularization (TLR) rates were 3.0 ± 1.3 and 8.5 ± 2.3%. Unacceptable acute recoil (&gt;30%) was found in 74% of cases that needed repeat revascularization. No acute vessel closures occurred after DCB treatment.ConclusionThe DCB-only strategy using a paclitaxel-coated (CEE) device was technically feasible, safe, and effective in an all-comers population. Acute recoil was found as a significant cause of restenosis after the DCB-only strategy.
Impaired heart rate variability in patients with arrhythmogenic cardiomyopathy: A multicenter retrospective study in China
Authors: Zhang Baowei , Zhou Chunjiang , Liu Jinqiu , Zhang Jinlin , Jiang Chenyang , Tang Min , Xie Jiaxi , Wu Yizhang , Xie Xin , Li Xiaorong , Yu Jinbo , Wang Xuecheng , Cheng Dian , Zhou Jian , Chen Zijun , Fan Fenghua , Zhou Xiujuan , Tao Aibin , Yang Bing 
Published: October 2022

BackgroundCardiac sympathetic nerve system (SNS) might play an important role in arrhythmogenesis of arrhythmogenic cardiomyopathy (ACM). This study aims to assess the activity of cardiac SNS in ACM patients by heart rate variability (HRV), and to investigate its predictive value for sustained ventricular tachycardia (sVT).MethodsA total of 88 ACM patients and 65 sex- and age- matched healthy participants were enrolled. The time domain measures were used to evaluate the activity of cardiac SNS. An independent cohort with 48 ACM patients was as the validation cohort.ResultsACM patients had lower levels of standard deviation of all NN intervals (SDNN) [118.0 (90.3, 136.8) vs. 152.0 (132.5, 174.5) ms,p&lt; 0.001] compared with healthy participants. Further analysis showed ACM patients with sVT had lower levels of SDNN than those without sVT (105.0 ± 28.1 vs. 131.8 ± 33.1 ms,p&lt; 0.001). Multivariate logistic regression analysis showed SDNN was independently associated with sVT in ACM patients [odds ratio (OR) 0.59, 95% confidence interval (CI) (0.45–0.78),p&lt; 0.001]. Receiver operating characteristics curve demonstrated SDNN had clinical values in predicting sVT in ACM patients [area under the curve (AUC) = 0.73, 95% CI (0.63–0.84),p&lt; 0.001], which was verified in the validation cohort.ConclusionThe present study suggests that HRV is impaired in patients with ACM, and the SDNN level has a moderate value in risk stratification for sVT in ACM patients. In addition, the finding might provide new target for the further management of ACM with integrated traditional Chinese and western medicine.
Bone and mineral metabolism in patients with primary aldosteronism: A systematic review and meta-analysis
Authors: Wang Anning , Wang Yuhan , Liu Hongzhou , Hu Xiaodong , Li Jiefei , Xu Huaijin , Nie Zhimei , Zhang Lingjing , Lyu Zhaohui 
Published: October 2022

PurposePatients with primary aldosteronism (PA) tend to exhibit a high prevalence of osteoporosis (OP) that may vary by whether PA is unilateral or bilateral, and responsive to PA treatment. To explore relationships between bone metabolism, PA subtypes, and treatment outcomes, we performed a systematic review and meta-analysis.MethodsThe PubMed, Embase, and Cochrane databases were searched for clinical studies related to PA and bone metabolism markers. Articles that met the criteria were screened and included in the systematic review; the data were extracted after evaluating their quality. R software (ver. 2022-02-16, Intel Mac OS X 11.6.4) was used for the meta-analysis.ResultsA total of 28 articles were subjected to systematic review, of which 18 were included in the meta-analysis. We found that PA patients evidenced a lower serum calcium level (mean difference [MD] = –0.06 mmol/L, 95% confidence interval [CI]: −0.10 ~ −0.01), a higher urine calcium level (MD = 1.29 mmol/24 h, 95% CI: 0.81 ~ 1.78), and a higher serum parathyroid hormone (PTH) level (MD = 2.16 pmol/L, 95% CI: 1.57 ~ 2.75) than did essential hypertension (EH) subjects. After medical treatment or adrenal surgery, PA patients exhibited a markedly increased serum calcium level (MD = –0.08 mmol/L, 95% CI: –0.11 ~ –0.05), a decreased urine calcium level (MD = 1.72 mmol/24 h, 95% CI: 1.00 ~ 2.44), a decreased serum PTH level (MD = 2.67 pmol/L, 95% CI: 1.73 ~ 3.62), and an increased serum 25-hydroxyvitamin D (25-OHD) level (MD = –6.32 nmol/L, 95% CI: –11.94 ~ –0.70). The meta-analysis showed that the ser um PTH level of unilateral PA patients was significantly higher than that of bilateral PA patients (MD = 0.93 pmol/L, 95% CI: 0.36 ~ 1.49) and the serum 25-OHD lower than that of bilateral PA patients (MD = –4.68 nmol/L, 95% CI: –7.58 ~ 1.77). There were, however, no significant differences between PA and EH patients of 25-OHD, or BMD of femoral neck and lumbar spine. BMDs of the femoral neck or lumbar spine did not change significantly after treatment. The meta-analytical results were confirmed via sensitivity and subgroup analyses.ConclusionExcess aldosterone was associated with decreased serum calcium, elevated urinary calcium, and elevated PTH levels; these effects may be enhanced by low serum 25-OHD levels. The risks of OP and fracture might be elevated in PA patients, especially unilateral PA patients, but could be reduced after medical treatment or adrenal surgery. In view, however, of the lack of BMD changes, such hypothesis needs to be tested in further studies.
Durability of glucose-lowering effect of dulaglutide in patients with type 2 diabetes mellitus: A real-world data study
Authors: Kim Hwi Seung , Cho Yun Kyung , Kim Myung Jin , Jung Chang Hee , Park Joong-Yeol , Lee Woo Je 
Published: October 2022

IntroductionType 2 diabetes mellitus (T2DM) is a chronic, progressive disease requiring lifelong treatment, and durable medication is essential for maintaining stable glycemic control. This study aimed to evaluate the long-term efficacy of dulaglutide in participants who have continued the drug for more than one year.MethodsWe conducted a retrospective study on 605 participants, who used dulaglutide for over one year between 2016 and 2020. Changes in glycosylated hemoglobin (HbA1c), fasting plasma glucose, and bodyweight from baseline to last prescription day were assessed. Adherence was evaluated by the proportion of days covered (PDC), and a PDC value ≥ 0.80 was considered adherent.ResultsThe mean age was 54.0 ± 11.1 years, and 46.1% were female. The mean baseline HbA1c, bodyweight, and duration of diabetes were 8.8% (72.7 mmol/mol), 75.6 kg, and 12.2 years, respectively. During the mean follow-up of 33.1 months, HbA1c and bodyweight decreased by 1.28% (14 mmol/mol, P &lt; 0.001) and by 3.19 kg (P &lt; 0.001), respectively. The participants were highly adherent with PDC ≥ 0.80 in 92.4% of the participants.ConclusionIn T2DM patients, long-term dulaglutide treatment was effective in maintaining HbA1c and weight reduction. Dulaglutide could be a favorable option of long-term treatment in real-world clinical practice.
The global human settlement layer sets a new standard for global urban data reporting with the urban centre database
Authors: Melchiorri Michele 
Published: October 2022

Monitoring of sustainable development goals (SDGs) requires a wealth of updated, reliable, and comparable data on planet Earth with respect to societal activities and society–environment interactions. Despite the massive big-data archives available today, salient data are missing for key thematic domains and geographical areas. Even for cities, which are the most prominent manifestations of human agglomeration, the data are scarce, sectoral, and scattered. Earth observation may help reconcile the disparities between data-rich and data-poor territories. The Global Human Settlement Layer (GHSL) project of the European Commission has generated an open-source global dataset on cities—the GHSL Urban Centre Database (GHS-UCDB). This database describes more than 10,000 Urban Centres in 2015, with their locations, extent, and sets of geographical, socio-economic, and environmental attributes, as well as multi-temporal data records (covering a time span of up to 40 years) (Figure 6). The database combines information extracted from satellite imagery with physical and socio-economic information from several voluminous and heterogeneous sources provided by researchers and institutions as open geospatial data. The paradigm introduced with the GHS-UCDB relies on massive geospatial data integration and harmonisation conducted in the GIS environment (mainly via spatial joins and zonal statistics). The range and depth of geospatial and statistical variables in this dataset represent a new standard foundation for information on cities—more than doubling the number of cities usually reported by international organisations and offering the capacity to understand dynamics, e.g., on population, greenness, economic productivity, night-time light, and pollutant emissions. Moreover, the database offers the basis to estimate SDG indicators and other essential variables for the Post 2015 Development Agenda.
Breeding phenology and landscape use in all amphibian species from the Republic of Korea based on open-source data
Authors: Groffen Jordy , Andersen Desiree , Borzée Amaël 
Published: October 2022

Biodiversity is declining worldwide with habitat loss and climate change being among the main threats. While it is easy to quantify habitat loss, the impacts of climate change are less obvious. It is therefore important to understand species habitat use and breeding phenology before a significant shift results in the loss of knowledge. Here, we determined the habitat use and breeding phenology for all Korean amphibian species based on citizen science (8,763 observations), collected between 1997–2020. We found the breeding seasons as we defined them to be generally shorter than described in the literature despite large variations between species. Species were further dichotomised into early and late breeders with breeding periods peaking in mid-March and mid-June respectively. We found early breeding species to have a shortened hibernating period with only six days being consistently devoid of observations over the 23 years of the period studied for the species with the shortest inactive season. Habitat use was significantly different between all species, with pair-wise comparisons highlighting greater differences among rather than within genera, highlighting the threats to species across all genera. In addition, our results set a baseline for future analyses about climate change and habitat use.
Case Report: Prenatal diagnosis of fetal tetrasomy 9p initially identified by non-invasive prenatal testing
Authors: Yu Jialing , Chen Na , Chen Min , Shen Min , Qian Yeqing , Dong Minyue 
Published: October 2022

Tetrasomy 9p is a rare syndrome characterized by fetal growth restriction, Dandy-Walker malformation, cardiac anomalies, and facial abnormalities and is discovered by ultrasound during the prenatal examination. Herein, we report a fetus of tetrasomy 9p without obvious phenotypic manifestations during the first trimester that was identified by non-invasive prenatal testing (NIPT). NIPT revealed that the gain of 9p24.3–9p11 that was approximately 46.36 Mb in size. Karyotyping of amniocytes indicated an additional marker in all metaphase. Chromosome microarray and fluorescence in situ hybridization on uncultured amniocytes revealed tetrasomic of 9p24.3q13, and that the supernumerary chromosome is a dicentric isochromosome consisted of two copies of the 9p arm. Taken together, it was indicated that the fetal karyotype was 47,XY,+idic (9) (q13), and that multiple techniques are crucial to the prenatal diagnosis.
Prognostic value of nutritional and inflammatory indicators in females with esophageal squamous cell cancer: A propensity score matching study
Authors: Li Yuping , Luo Huaichao , Ye Bo , Zhang Kaijiong , Liu Chang , Zu Ruiling , Ni Sujiao , He Qiao , Rao Lubei , Wang Qifeng , Wang Dongsheng 
Published: October 2022

Background: Esophageal squamous cell cancer (ESCC) is a disease with a male predominance. Accordingly, the applicability of prognostic indicators values previously set for the general population with ESCC has not been reported for determining the physical state in females.Methods: Patients with ESCC were pooled from 2009 to 2017 at Sichuan Cancer Hospital. We determined the differences in the nutritional and inflammatory indicators between gender by sex-stratified survival analysis in all cohorts (n = 2,660) and matching cohorts (n = 483 pairs) separately. Propensity score matching (PSM) was employed to eliminate selection bias between genders. We further performed the prognostic value of total cholesterol (TC) by subgroup analysis in the female cohort. The area ROC curve was used to assess the predictive performance of TC in females.Results: There were a total of 2,660 patients with ESCC, of whom 2,173 (81.7%) were male and 487 (18.3%) were female. Before PSM, the prognostic nutritional index was an independent factor for OS in males but not in females. For cohort with or without matching, TC was an independent prognostic factor in females not for males. Furthermore, female patients with high TC level had significant poor OS in stages III and IV. The AUCs of TC were 0.63 and 0.70 for predicting 3- and 5-year OS, respectively.Conclusion: Based on a much larger cohort, we confirmed that gender was a significant prognostic factor for ESCC patients. Interestingly, we found a significant difference in TC related to ESCC prognosis between genders. Collectively, TC might be an independent prognostic factor in females with ESCC.