bluuebunny/crossref_metadata_2025_split huggingface dataset:
SARS-CoV-2 variants and the risk of pediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 among children in Germany
Authors: Sorg A. L. , Schönfeld V. , Siedler A. , Hufnagel M. , Doenhardt M. , Diffloth N. , Berner R. , v. Kries R. , Armann J. 
Published: September 2022

Abstract
Purpose
To investigate the relationship between the risk of pediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 (PIMS-TS) in children and the predominance of different SARS-CoV-2 variants of concern (VOC) over time.

Methods
In relation to the Alpha, Delta, and Omicron VOC phases of the pandemic, the risk of developing PIMS-TS was calculated by analyzing data for rtPCR-confirmed SARS-CoV-2 infections reported to the German statutory notification system, along with data captured by a separate, national PIMS-TS registry. Both overall infection rates and age group-specific ratios of PIMS-TS during the different pandemic phases were calculated using the Alpha period as the baseline.

Results
The PIMS-TS rate changed significantly over time. When the Alpha VOC was dominant [calendar week (CW) 11 in March–CW 31 in August 2021], the PIMS-TS rate was 6.19 [95% confidence intervals (95% CI) 5.17, 7.20]. When Delta prevailed (CW 32 in August 2021–CW 4 in January 2022), the rate decreased to 1.68 (95% CI 1.49, 1.87). During the Omicron phase (CW 5 in January–CW 16 in April 2022), the rate fell further to 0.89 (95% CI 0.79, 1.00). These changes correspond to a decreased PIMS-TS rate of 73% (rate ratio 0.271, 95% CI 0.222; 0.332) and 86% (rate ratio 0.048, 95% CI 0.037; 0.062), respectively, in comparison to the Alpha period. Rate ratios were nearly identical for all age groups.

Conclusion
The data strongly suggest an association between the risk for PIMS-TS and the prevailing VOC, with highest risk related to Alpha and the lowest to Omicron. Given the uniformity of the decreased risk across age groups, vaccination against SARS-CoV-2 does not appear to have a significant impact on the risk of children developing PIMS-TS.
Construction and validation of an early warning model for predicting the acute kidney injury in elderly patients with sepsis
Authors: Xin Qi , Xie Tonghui , Chen Rui , Wang Hai , Zhang Xing , Wang Shufeng , Liu Chang , Zhang Jingyao 
Published: September 2022

Abstract
Background
Sepsis-induced acute kidney injury (S-AKI) is a significant complication and is associated with an increased risk of mortality, especially in elderly patients with sepsis. However, there are no reliable and robust predictive models to identify high-risk patients likely to develop S-AKI. We aimed to develop a nomogram to predict S-AKI in elderly sepsis patients and help physicians make personalized management within 24 h of admission.

Methods
A total of 849 elderly sepsis patients from the First Affiliated Hospital of Xi’an Jiaotong University were identified and randomly divided into a training set (75%, n = 637) and a validation set (25%, n = 212). Univariate and multivariate logistic regression analyses were performed to identify the independent predictors of S-AKI. The corresponding nomogram was constructed based on those predictors. The calibration curve, receiver operating characteristics (ROC)curve, and decision curve analysis were performed to evaluate the nomogram. The secondary outcome was 30-day mortality and major adverse kidney events within 30 days (MAKE30). MAKE30 were a composite of death, new renal replacement therapy (RRT), or persistent renal dysfunction (PRD).

Results
The independent predictors for nomogram construction were mean arterial pressure (MAP), serum procalcitonin (PCT), and platelet (PLT), prothrombin time activity (PTA), albumin globulin ratio (AGR), and creatinine (Cr). The predictive model had satisfactory discrimination with an area under the curve (AUC) of 0.852–0.858 in the training and validation cohorts, respectively. The nomogram showed good calibration and clinical application according to the calibration curve and decision curve analysis. Furthermore, the prediction model had perfect predictive power for predicting 30-day mortality (AUC = 0.813) and MAKE30 (AUC = 0.823) in elderly sepsis patients.

Conclusion
The proposed nomogram can quickly and effectively predict S-AKI risk in elderly sepsis patients within 24 h after admission, providing information for clinicians to make personalized interventions.
The prevention of falls in patients with Parkinson’s disease with in-home monitoring using a wearable system: a pilot study protocol
Authors: Campani Daiana , De Luca Enrico , Bassi Erika , Busca Erica , Airoldi Chiara , Barisone Michela , Canonico Massimo , Contaldi Elena , Capello Daniela , De Marchi Fabiola , Magistrelli Luca , Mazzini Letizia , Panella Massimiliano , Scotti Lorenza , Invernizzi Marco , Dal Molin Alberto 
Published: September 2022

Abstract
Background
Parkinson's disease (PD) is a chronic, progressive neurodegenerative condition that gradually worsens motor function and leads to postural instability and, eventually, falls. Several factors may influence the frequency of future falls, such as slowness, freezing of gait, loss of balance, and mobility problems, cognitive impairments, and the number of previous falls. The TED bracelet is an advanced technological wearable device able to predict falls.

Aims
This principal aim is to investigate the feasibility of a full-scale research project that uses the TED bracelet to identify whether individuals with PD are at risk of falling.

Methods
This study will involve a pilot prospective observational study design; the subjects will include 26 patients suffering from mild PD and 26 others with no PD and no gait problems. Data will be collected from the TED bracelet and then compared to a paper-based fall diary. The enrolled participants will have a scheduled outpatient evaluation to collect both clinical and instrumental data as well as biological samples.

Discussion
This pilot study could then be implemented in a larger form to further evaluate the effectiveness of the TED device. Finally, it will help further develop gait monitoring systems for people with Parkinson's disease and other neurodegenerative diseases that can affect physical function and mobility, such as dementia and Alzheimer's.

Conclusions
Preventing falls and their complications could lead to major advancements in the quality of home care for patients with PD, which would significantly impact the quality of life of both these patients and their caregivers.
The psychosocial needs of patients who have chronic kidney disease without kidney replacement therapy: a thematic synthesis of seven qualitative studies
Authors: Seery Christina , Buchanan Sarah 
Published: September 2022

Abstract
Background
Limited quantitative data suggests that patients who have chronic kidney disease without kidney replacement therapy (CKD without KRT) may present with psychosocial needs just as patients who have acute kidney injury and are treated by dialysis (AKI stage 3D) do. This systematic review aims to synthesise qualitative research on patients’ experiences of CKD without KRT to provide further insight into patients’ experience of the healthcare they receive and simultaneously, their psychosocial needs, to inform the development of appropriate psychological interventions.

Methods
The review followed ENTREQ guidelines. PubMed/MEDLINE, PsycINFO, EMBASE and CINAHL were searched in July and August 2021. Qualitative studies in English on the experiences of CKD without KRT care were included in the review. Thematic synthesis was conducted on the findings of the included studies.

Results
The search identified 231 articles for screening. Eight studies met the inclusion criteria, and one was excluded at the quality assessment stage. The final seven articles [n = 130 patients] were analysed. Five themes on psychosocial needs were developed: addressing patients’ CKD-related educational needs, supporting the patient’s relationships, honouring the patient’s need for control, adjusting to change, and recognising fear of disease and treatment.

Discussion
This review highlights the range of psychosocial needs of patients who have CKD without KRT. There are numerous intervention options that clinicians may develop that could benefit patients and address multiple needs, such as group educational programmes.

Graphical abstract
Printable Aligned Single-Walled Carbon Nanotube Film with Outstanding Thermal Conductivity and Electromagnetic Interference Shielding Performance
Authors: Zeng Zhihui , Wang Gang , Wolan Brendan F. , Wu Na , Wang Changxian , Zhao Shanyu , Yue Shengying , Li Bin , He Weidong , Liu Jiurong , Lyding Joseph W. 
Published: September 2022

AbstractUltrathin, lightweight, and flexible aligned single-walled carbon nanotube (SWCNT) films are fabricated by a facile, environmentally friendly, and scalable printing methodology. The aligned pattern and outstanding intrinsic properties render “metal-like” thermal conductivity of the SWCNT films, as well as excellent mechanical strength, flexibility, and hydrophobicity. Further, the aligned cellular microstructure promotes the electromagnetic interference (EMI) shielding ability of the SWCNTs, leading to excellent shielding effectiveness (SE) of ~ 39 to 90 dB despite a density of only ~ 0.6 g cm−3 at thicknesses of merely 1.5–24 µm, respectively. An ultrahigh thickness-specific SE of 25 693 dB mm−1 and an unprecedented normalized specific SE of 428 222 dB cm2 g−1 are accomplished by the freestanding SWCNT films, significantly surpassing previously reported shielding materials. In addition to an EMI SE greater than 54 dB in an ultra-broadband frequency range of around 400 GHz, the films demonstrate excellent EMI shielding stability and reliability when subjected to mechanical deformation, chemical (acid/alkali/organic solvent) corrosion, and high-/low-temperature environments. The novel printed SWCNT films offer significant potential for practical applications in the aerospace, defense, precision components, and smart wearable electronics industries.
Metal–Organic Framework Materials for Electrochemical Supercapacitors
Authors: Cao Ziwei , Momen Roya , Tao Shusheng , Xiong Dengyi , Song Zirui , Xiao Xuhuan , Deng Wentao , Hou Hongshuai , Yasar Sedat , Altin Sedar , Bulut Faith , Zou Guoqiang , Ji Xiaobo 
Published: September 2022

AbstractExploring new materials with high stability and capacity is full of challenges in sustainable energy conversion and storage systems. Metal–organic frameworks (MOFs), as a new type of porous material, show the advantages of large specific surface area, high porosity, low density, and adjustable pore size, exhibiting a broad application prospect in the field of electrocatalytic reactions, batteries, particularly in the field of supercapacitors. This comprehensive review outlines the recent progress in synthetic methods and electrochemical performances of MOF materials, as well as their applications in supercapacitors. Additionally, the superiorities of MOFs-related materials are highlighted, while major challenges or opportunities for future research on them for electrochemical supercapacitors have been discussed and displayed, along with extensive experimental experiences.
BIM-Based Safety Leading Indicators Measurement Tool for Construction Sites
Authors: Dadashi Haji Mostafa , Behnam Behrouz , Sebt Mohammad Hassan , Ardeshir Abdollah , Katooziani Ali 
Published: September 2022

AbstractRecognition of safety leading indicators is considered as an important part of safety management in construction projects to prevent hazardous accidents occurrence. In the available literature, the lack of a comprehensive proactive approach for assessing safety, based on active safety leading indicators is tangible. In this study, BIM and knowledge base are integrated to develop a safety management framework, then, this framework is implemented in a case study to assess its performance. Safety leading indicators are extracted from experts’ expertise, documents, and best practice, and then the relationships among safety leading indicators, activities, and their attributes are established; these pieces of knowledge are stored in a safety leading indicator knowledge base. To measure the impacts of these indicators on the project, a framework is developed to integrate the knowledge base and building information modeling (BIM). The developed add-on generates a heat-map to visualize the impacts of the safety leading indicators on a daily basis, and it also produces a textual result sheet. To verify the effectiveness and efficiency of the developed tool a survey from professionals is conducted. This tool provides a way to automatically assess the impacts of the safety leading indicators. Using its results, safety managers and project participants can make important decisions to reduce hazards. The results also indicate that accidents occurring in the construction site dropped by 38% after employing the presented framework.
Potentials of oxymethylene-dimethyl-ether in diesel engine combustion
Authors: Saupe Christopher , Atzler Frank 
Published: September 2022

AbstractThe increasing CO2 concentration in the atmosphere and the resulting climate change require an immediate and efficient reduction of anthropogenic carbon-dioxide emission. This target can be achieved by the usage of CO2-neutral fuels even with current technologies (Schemme et al. in Int J Hydrogen Energy 45:5395–5414, 2020). Diesel engines in particular are amongst the most efficient prime movers. Using oxymethylene-dimethyl-ether (OME) it is possible to solve the hitherto existing Soot-NOx-Trade-off. OME has bounded oxygen in the molecular chain. This reduces the formation of soot, but equally the calorific value. But in considerance of the physical and chemical properties of OME, it could be useful to optimize the standard diesel engine into an OME engine. As a result, single-cylinder tests were performed to obtain a detailed analysis of the differences between OME3-5 and commercially available DIN EN 590 Diesel. Based on the fact that OME has gravimetrically less than half the calorific value of diesel, twice the fuel mass must be injected for the same energy release in the combustion chamber. Therefore, at the beginning of the investigations, a variation of the injector flow rate was carried out by means of different nozzle hole diameters. The evaluation of the results included the fundamental differences in the combustion characteristics of both fuels and the determination of efficiency-increasing potentials in the conversion of OME3-5. Due to the lower ignition delay and the shorter combustion time of OME, potentials in the optimisation of the injection setting became apparent. Higher energy flows over the combustion chamber wall were noticeable in operation with OME. To get to the bottom of this, the single-cylinder investigations were supported by tests on the optically accessible high-pressure chamber and the single-cylinder transparent engine. The optical images showed a narrower cone angle and greater penetration depth of the OME injection jet compared to the diesel injection jet. This confirmed the results from the single-cylinder tests. This provides further potential in the design of the injector nozzle to compensate for these deficits. Overall, this work shows that operation with OME in a classic diesel engine is possible without any significant loss in efficiency and with little effort in the hardware. However, it is also possible to achieve more efficient use of the synthetic fuel with minor adjustments.
Does engagement help to reduce insomnia when workers are emotionally exhausted?
Authors: Fernández-Salinero Samuel , Topa Gabriela , Fernández Muñoz Juan José 
Published: September 2022

AbstractInsomnia is one of the most common problems, affecting more than 35% of the world’s population. To achieve a better understanding of this problem the focus of this research is to understand how emotional exhaustion at work may lead to insomnia. To help to combat it, we tested a mediation model including engagement factors. The sample was composed of 823 participants. 38.3% (315 subjects) were male and 61.7% (508 subjects) were female. Mean age was 42.65 years old (9.05 = SD). Main results showed that emotional exhaustion is directly and statistically significant related to insomnia. However, different engagement factors showed different weights in buffering this relationship. Emotional exhaustion showed a statistically significant impact on insomnia. Vigor and absorption helped to buffer the impact of emotional exhaustion over insomnia. Our study has some limitations. First, the sample was acquired by not aleatory processes. Another limitation is that our sample was composed of individuals with decision-making capacity. Lastly, our research is a transversal study. Future research should take these limitations into account and conduct longitudinal research with aleatory sampling procedures.
Usability of clinical decision support systems
Authors: Mucha Henrik , Robert Sebastian , Breitschwerdt Rüdiger , Fellmann Michael 
Published: September 2022

AbstractUsability is considered a major success factor for current and future decision support systems. Such systems are increasingly used to assist human decision-makers in high-stakes tasks in complex domains such as health care, jurisdiction or finance. Yet, many if not most expert systems—especially in health care—fail to deliver the degree of quality in terms of usability that its expert users are used to from their personal digital consumer products. In this article, we focus on clinical decision support systems (CDSS) as an example for how important a human-centered design approach is when designing complex software in complex contexts. We provide an overview of CDSS classes, discuss the importance of systematically exploring mental models of users, and formulate challenges and opportunities of future design work on CDSS. We further provide a case study from a current research project to illustrate how we used codesign as a practical approach to produce usable software in a real-world context.Practical Relevance: We make a point for usability to be considered a major success factor and non-negotiable characteristic of expert software. With software evolving into virtual coworkers in terms of supporting human decision-making in complex, high-risk domains, the necessity of and demand for systems that are unambiguously understandable and interpretable for their expert users have never been higher. We show that this is a real-world problem with high practical relevance by describing our work in the domain of clinical decision support systems (CDSS) as an example. We introduce the topic and a classification of CDSS. Thus, we highlight a conceptual framework of how to approach complex domains from a technology designer’s point of view. We continue by explaining why usability must be regarded as a major goal in software development. We derive challenges and opportunities that may well be transferred to other domains. Finally, be including a real-world example from our own professional work we propose a practical approach towards taking the challenges and exploiting the associated opportunities.
Effects of the Fractionation of the Nitrogen Fertilization on Root Nitrate Uptake and Vine Agronomic Performance in Pinot Gris Grapevines in a Temperate Climate
Authors: Zanin Laura , Nerva Luca , Alessandrini Massimiliano , Tomasi Diego , Pinton Roberto , Lucchetta Marco , Chitarra Walter , Gaiotti Federica 
Published: September 2022

AbstractThe study aims to investigate at a physiological and molecular level the root absorption of nitrogen (N) during the annual cycle of grapevine. The study was performed on potted Pinot Gris plants grafted on Kober 5BB and grown for two consecutive years in a semi-controlled environment (Northeast, Italy). The study compared the response of plants N-fertilized in spring (T1), or in spring and in post-harvest (T2) or no-N fertilized (C). Results showed that under our climate conditions nitrate was taken up by the grapevines when applied both in spring or in spring and post-harvest. The nitrate acquisition in T1 roots is mediated at molecular and physiological level by a higher activation of high-affinity nitrate-transport system to take up nitrate in comparison to no-fertilized plants. Comparing the two N fertilization managements, the dynamic of nitrate uptake rates showed different patterns with an overall late response of High-Affinity Transport System when the application of part of N-fertilization was delayed to post-harvest (T2) in comparison to T1. Nevertheless, during the 2 years of the trial the fractionation of N fertilization applied in spring and post-harvest did not negatively affect the yield and quality parameters of vines. An increase of N concentration in T2 roots after two consecutive growing seasons may suggest that the fractionation can lead to beneficial effects on long period. Results of this work contribute to improve the comprehension of N acquisition in grapevine in order to optimize the use of N inputs in vineyard.
Interaction between moxifloxacin and Mcl-1 and MITF proteins: the effect on growth inhibition and apoptosis in MDA-MB-231 human triple-negative breast cancer cells
Authors: Beberok Artur , Rok Jakub , Rzepka Zuzanna , Marciniec Krzysztof , Boryczka Stanisław , Wrześniok Dorota 
Published: September 2022

Abstract
Background
Microphthalmia-associated transcription factor (MITF) activates the expression of genes involved in cellular proliferation, DNA replication, and repair, whereas Mcl-1 is a member of the Bcl-2 family of proteins that promotes cell survival by preventing apoptosis. The objective of the present study was to verify whether the interaction between moxifloxacin (MFLX), one of the fluoroquinolones, and MITF/Mcl-1 protein, could affect the viability, proliferation, and apoptosis in human breast cancer using both in silico and in vitro models.

Methods
Molecular docking analysis (in silico), fluorescence image cytometry, and Western blot (in vitro) techniques were applied to assess the contribution of MITF and Mcl-1 proteins in the MFLX-induced anti-proliferative and pro-apoptotic effects on the MDA-MB-231 breast cancer cells.

Results
We indicated the ability of MFLX to form complexes with MITF and Mcl-1 as well as the drug’s capacity to affect the expression of the tested proteins. We also showed that MFLX decreased the viability and proliferation of MDA-MB-231 cells and induced apoptosis via the intrinsic death pathway. Moreover, the analysis of the cell cycle progression revealed that MFLX caused a block in the S and G2/M phases.

Conclusions
We demonstrated for the first time that the observed effects of MFLX on MDA-MB-231 breast cancer cells (growth inhibition and apoptosis induction) could be related to the drug’s ability to interact with MITF and Mcl-1 proteins. Furthermore, the presented results suggest that MITF and Mcl-1 proteins could be considered as the target in the therapy of breast cancer.

Graphical abstract
On q-scale functions of spectrally negative Lévy processes
Authors: Behme Anita , Oechsler David , Schilling René 
Published: September 2022

AbstractWe obtain series expansions of the q-scale functions of arbitrary spectrally negative Lévy processes, including processes with infinite jump activity, and use these to derive various new examples of explicit q-scale functions. Moreover, we study smoothness properties of the q-scale functions of spectrally negative Lévy processes with infinite jump activity. This complements previous results of Chan et al. (Prob. Theory Relat. Fields150, 2011) for spectrally negative Lévy processes with Gaussian component or bounded variation.