bluuebunny/crossref_metadata_2025_split huggingface dataset:
Summer, Sun and SAD in Early Modern England
Authors: Meredith Tayler 
Published: July 2022

Abstract
Utilising a corpus of popular health regimens, including Robert Burton's magnum opus The Anatomy of Melancholy (1621), this article takes account of the climatic conditions that shaped contemporary understandings of emotional cycles, with specific reference to sunlight. As such, this article moves beyond previous histories of sunlight that have cast it as a purely material force, and contributes an entangled environmental, embodied and emotional history of sunlight in early modern England. England's interest in climate, I argue, was less characterised by chronic malaise than by a complex matrix of passions and affections. From the dog days of summer when choler ran high, to the dark, melancholy evenings of midwinter, the English climate bred a cycle of competing passions. Such a cycle is indicative of a much more complex relationship between seasons and emotions than is reflected in the existing historiography. Rather than producing a fluctuating cycle of different moods because of an essential biological link between seasons and feelings, the early modern climate produced a range of affects that were contingent upon how people understood weather, climate, sunlight and their influences.
MODIFIKASI KOLAM OLAK TIPE AMBANG BERGIGI DALAM RANGKA REHABILITASI KERUSAKAN BENDUNG CIKEUSIK DI JAWA BARAT
Authors: Zulfan, ST., MSc James , Rakhmawati Tsani , Rimawan Ririn , Samskerta I Putu , Lestari Slamet 
Published: July 2022

The presence of hydraulic jumps downstream of the weir structure is a natural occurrence that indicates a change in supercritical to subcritical flow characteristics. Hydraulic jump is one indicator of the dissipation of energy in the stilling basin. Therefore, the absence of a hydraulic jump can be a problem for some weirs, as happened in the Cikeusik Weir, which experienced damage to the stilling pool floor so that the energy dissipation did not function optimally. This paper will discuss the potential causes of damage to the Cikeusik weir and alternative designs for its countermeasures. A physical model test was carried out in the laboratory with a scale of 1: 40 to obtain an appropriate alternative to the stilling pond design for the Cikeusik weir. The tests were carried out with variations in the discharge Q2 years, Q25 years, and Q100 years, respectively. Three model tests were conducted, namely the existing and two modified designs. Based on the model testing results, extending stilling basin floor length with a dentated end sill and adding downstream riprap is the most optimal alternative because it has an energy reduction effectiveness of up to 80% and the lowest downstream scour potential compared to other options. The results of this test are expected not only to be used as an alternative to mitigate the damage to the Cikeusik weir but also to other locations that have similar problems. Keywords : Cikeusik Weir, stilling basin, Froude number, local scour, physical model
What Factors Determine the Production of Independent Smallholder Oil Palm?
Authors: Yanita Mirawati , Suandi  
Published: July 2022

Oil palm is the most efficient crop in producing oil than other crops, such as soybean, rapeseed, and sunflower. However, the oil palm plantation of independent smallholders faced low productivity in terms of input used. This study aims to determine the production factors that influence independent oil palm smallholders in Kumpeh Sub-district, Muaro Jambi District. This research was conducted in three villages in Kumpeh, namely Mekarsari, Betung, and Seponjen. Samples consisted of 63 smallholders and were taken using the Simple Random Sampling method. The data were analyzed descriptively and subjected to statistical tests of multiple linear regression analysis. The results show an R2 of 0.888, indicating that the model variables can explain 88.8 percent of the oil palm production variation. The F test resulted in a value of 115.299, showing that the production variables together have a real effect on production. Partially, the independent variables that have a real and significant impact on oil palm production at a realistic level (α) of 5 percent are land area, fertilizer, and pesticides. At the same time, labor does not significantly affect palm oil production.
Pemberdayaan Ibu-Ibu PKK melalui Budidaya Sayuran untuk Pemenuhan Pangan Keluarga dan Mewujudkan Program P2L pada Masa Pandemi Covid-19
Authors: Susilawati Susilawati , Ammar Muhammad , Sulaiman Firdaus , Harun Muhammad Umar , Irmawati Irmawati 
Published: July 2022

Masyarakat Desa Tanjung Utara sebagian besar tidak memanfaatkan lahan atau pekarangan karena sering terjadi banjir secara periodik setiap tahun. Saat ini, Indonesia bahkan dunia sedang mengalami covid-19 yang tidak hanya membawa masalah kesehatan masyarakat, tetapi juga berimplikasi luas, seperti kelancaran distribusi pangan. Pemerintah melalui Kementerian Pertanian telah membentuk program Pekarangan Pangan Lestari. Program ini sangat tepat untuk diwujudkan di masa covid-19. Kegiatan ini bertujuan 1) Memberdayakan masyarakat untuk memanfaatkan pekarangan dengan menanam berbagai tanaman sayuran untuk pemenuhan gizi keluarga dan memberi penyuluhan tentang manfaat tanaman sayuran, 2) Mensosialisasikan program Pekarangan Pangan Lestari (P2L). Melalui berbagai teknik budidaya yang dapat diterapkan dengan membuat demonstrasi plot (demplot) baik langsung lahan pekarangan maupun menggunakan metode-metode lain seperti small garden, hidroponik, vertikultur dan microgreens. Hasil kegiatan pengabdian telah meningkatkan pemahaman ibu-ibu mengenai budidaya sayuran di pekarangan dan program pekarangan pangan lestari.
Self-Masked Aldehyde Inhibitors of Human Cathepsin L Are Potent Anti-CoV-2 Agents
Authors: Zhu Jiyun , Li Linfeng , Drelich Aleksandra , Chenna Bala C. , Mellott Drake M. , Taylor Zane W. , Tat Vivian , Garcia Christopher Z. , Katzfuss Ardala , Tseng Chien-Te K. , Meek Thomas D. 
Published: July 2022

Cysteine proteases comprise an important class of drug targets, especially for infectious diseases such as Chagas disease (cruzain) and COVID-19 (3CL protease, cathepsin L). Peptide aldehydes have proven to be potent inhibitors for all of these proteases. However, the intrinsic, high electrophilicity of the aldehyde group is associated with safety concerns and metabolic instability, limiting the use of aldehyde inhibitors as drugs. We have developed a novel class of compounds, self-masked aldehyde inhibitors (SMAIs) which are based on the dipeptide aldehyde inhibitor (Cbz-Phe-Phe-CHO, 1), for which the P1 Phe group contains a 1′-hydroxy group, effectively, an o-tyrosinyl aldehyde (Cbz-Phe-o-Tyr-CHO, 2; (Li et al. (2021) J. Med. Chem. 64, 11,267–11,287)). Compound 2 and other SMAIs exist in aqueous mixtures as stable δ-lactols, and apparent catalysis by the cysteine protease cruzain, the major cysteine protease of Trypanosoma cruzi, results in the opening of the lactol ring to afford the aldehydes which then form reversible thiohemiacetals with the enzyme. These SMAIs are also potent, time-dependent inhibitors of human cathepsin L (Ki = 11–60 nM), an enzyme which shares 36% amino acid identity with cruzain. As inactivators of cathepsin L have recently been shown to be potent anti-SARS-CoV-2 agents in infected mammalian cells (Mellott et al. (2021) ACS Chem. Biol. 16, 642–650), we evaluated SMAIs in VeroE6 and A549/ACE2 cells infected with SARS-CoV-2. These SMAIs demonstrated potent anti-SARS-CoV-2 activity with values of EC50 = 2–8 μM. We also synthesized pro-drug forms of the SMAIs in which the hydroxyl groups of the lactols were O-acylated. Such pro-drug SMAIs resulted in significantly enhanced anti-SARS-CoV-2 activity (EC50 = 0.3–0.6 μM), demonstrating that the O-acylated-SMAIs afforded a level of stability within infected cells, and are likely converted to SMAIs by the action of cellular esterases. Lastly, we prepared and characterized an SMAI in which the sidechain adjacent to the terminal aldehyde is a 2-pyridonyl-alanine group, a mimic of both phenylalanine and glutamine. This compound (9) inhibited both cathepsin L and 3CL protease at low nanomolar concentrations, and also exerted anti-CoV-2 activity in an infected human cell line.
ADSCs Promote Tenocyte Proliferation by Reducing the Methylation Level of lncRNA Morf4l1 in Tendon Injury
Authors: Zhao Haibo , Chen Wei , Chen Jinli , Qi Chao , Wang Tianrui , Zhang Jing , Qu Di , Yu Tengbo , Zhang Yingze 
Published: July 2022

Objective: Tendons are the special connective tissue that connects bones to muscles and governs joint movement in response to loads passed by muscles. The healing of tendon injuries is still a challenge. In recent years, adipose-derived mesenchymal stem cells (ADSCs) have been increasingly used for tissue regeneration, but the underlying mechanism of tendon injury still remains unclear.Methods: High-throughput sequencing was used to identify a novel lncRNA, whose expression was significantly decreased in injured tendon compared with normal tendon. Furthermore, pyrosequencing, nuclear-cytoplasmic separation, FISH assay and qRT-PCR analysis were used to verify the level of lncRNA methylation in the injured tenocytes. lncRNA was confirmed to promote the proliferation of tenocytes by flow cytometry, wound healing assay, qRT-PCR, and western blot, and the target gene of lncRNA was predicted and verified. To confirm that ADSCs could repair injured tendons, ADSCs and injured tenocytes were co-cultured in vitro, and ADSCs were injected into injured tendons in vitro, respectively.Results: The lncRNA Morf4l1 promoter methylation in injured tendons led to down-regulation of its expression and inhibition of tenocyte proliferation. LncRNA Morf4l1 promoted the expression of TGF-β2 by targeting 3′U of miR-145-5p. After co-cultured ADSCs and injured tenocytes, the expression of lncRNA Morf4l1 was up-regulated, and the proliferation of injured tenocytes in vitro was promoted. The ADSCs were injected into the injured tendon to repair the injured tendon in vivo.Conclusion: This study confirmed that ADSCs promoted tendon wound healing by reducing the methylation level of lncRNA Morf4l1.
Sandwich-Structured h-BN/PVDF/h-BN Film With High Dielectric Strength and Energy Storage Density
Authors: Meng Guodong , She Junyi , Wang Changling , Wang Wenke , Pan Cheng , Cheng Yonghong 
Published: July 2022

Energy storage film is one of the most important energy storage materials, while the performance of commercial energy storage films currently cannot meet the growing industrial requirements. Hence, this work presents a h-BN/PVDF/h-BN sandwich composite structure film prepared by laminating a large area of ultrathin hexagonal boron nitride (h-BN) and polyvinylidene fluoride (PVDF), the existence of which was confirmed by using an optical microscope and elemental composition analysis based on scanning electron microscopy and X-ray diffraction. This film has an ultrahigh dielectric strength of 464.7 kV/mm and a discharged energy density of up to 19.256 J/cm3, which is much larger than the commercial energy storage film biaxially oriented polypropylene (BOPP) (&lt;2.5 J/cm3). Although the thickness of the h-BN film is only 70 nm compared with that of PVDF (about 12 μm), the dielectric strength of the sandwich-structured film presents a great increase. It is because of the excellent insulation performance of the h-BN film that helps to resist the electron injection and migration under high electric field, and then suppress the formation and growth of the breakdown path, leading to an improvement of the charge–discharge efficiency.
Clustering of Unhealthy Lifestyle and the Risk of Adverse Events in Patients With Atrial Fibrillation
Authors: Lee So-Ryoung , Choi Eue-Keun , Park Sang-Hyeon , Lee Seung-Woo , Han Kyung-Do , Oh Seil , Lip Gregory Y. H. 
Published: July 2022

BackgroundLittle is known regarding the risk of clinical outcomes depending on the clustering of lifestyle behaviors after atrial fibrillation (AF) diagnosis. This study evaluated the association between a cluster of healthy lifestyle behaviors and the risk of adverse outcomes in patients with AF.MethodsUsing the Korean National Insurance Service database, patients who were newly diagnosed with AF between 2009 and 2016 were included. A healthy lifestyle behavior score (HLS) was calculated by assigning 1 point each for non-current smoking, for non-drinking, and for performing regular exercise from the self-reported questionnaire in health examinations. The primary outcome was defined as major adverse cardiovascular event (MACE), including ischemic stroke, myocardial infarction, and hospitalization for heart failure.ResultsA total of 208,662 patients were included; 7.1% in HLS 0, 22.7% in HLS 1, 58.6% in HLS 2, and 11.6% in HLS 3 groups. Patients with HLS 1, 2, and 3 were associated with a lower risk of MACE than those with HLS 0 (adjusted hazard ratio [95% confidence interval (CI)]: 0.788 [0.762–0.855], 0.654 [0.604–0.708], and 0.579 [0.527–0.636], respectively). After propensity score weighting, consistent results were observed. The risk reduction of healthy lifestyle combinations was consistently observed in various subgroups, regardless of the CHA2DS2-VASc score and oral anticoagulant use.ConclusionIncreased number of healthy lifestyle behaviors was significantly associated with lower MACE risk in patients with new-onset AF. These findings support the promotion of a healthy lifestyle to reduce the risk of adverse events in patients with AF.
Wearable Biosensors in the Workplace: Perceptions and Perspectives
Authors: Tindale Lauren C. , Chiu Derek , Minielly Nicole , Hrincu Viorica , Talhouk Aline , Illes Judy 
Published: July 2022

ObjectivesWearable body and brain sensors are permeating the consumer market and are increasingly being considered for workplace applications with the goal of promoting safety, productivity, health, and wellness. However, the monitoring of physiologic signals in real-time prompts concerns about benefit and risk, ownership of such digital data, data transfer privacy, and the discovery and disclosure of signals of possible health significance. Here we explore the perceptions and perspectives of employers and employees about key ethical considerations regarding the potential use of sensors in the workplace.MethodsWe distributed a survey developed and refined based on key research questions and past literature to a wide range and size of industries in British Columbia, Canada. Both employers (potential Implementers) and employees (potential Users) were invited to participate.ResultsWe received 344 survey responses. Most responses were from construction, healthcare, education, government, and utilities sectors. Across genders, industries, and workplace sizes, we found a convergence of opinions on perceived benefit and concern between potential Implementers and potential Users regarding the motivation to use biosensors in the workplace. Potential Implementers and Users also agreed on issues pertaining to safety, privacy, disclosure of findings of possible medical significance, risks, data ownership, data sharing, and transfer of data between workplaces. The greatest variability between potential Users and Implementers pertained to data ownership.ConclusionStrong agreement in the perception of biosensor use in the workplace between potential Implementers and Users reflects shared interest, motivation, and responsibility for their use. The use of sensors is rapidly increasing, and transparency about key use factors–both practical and ethical–is essential to maintain the current and desirable level of solidarity.
Investigation of Valence Mixing in Sodium-Ion Battery Cathode Material Prussian White by Mössbauer Spectroscopy
Authors: Ericsson Tore , Häggström Lennart , Ojwang Dickson O. , Brant William R. 
Published: July 2022

Prussian white (PW), Na2Fe [Fe(CN)6], is a highly attractive cathode material for sustainable sodium-ion batteries due to its high theoretical capacity of ∼170 mAhg−1 and low-cost synthesis. However, there exists significant variability in the reported electrochemical performance. This variability originates from compositional flexibility possible for all Prussian blue analogs (PBAs) and is exasperated by the difficulty of accurately quantifying the specific composition of PW. This work presents a means of accurately quantifying the vacancy content, valence distribution, and, consequently, the overall composition of PW via Mössbauer spectroscopy. PW cathode material with three different sodium contents was investigated at 295 and 90 K. The observation of only two iron environments for the fully sodiated compound indicated the absence of [Fe(CN)6]4- vacancies. Due to intervalence charge transfer between iron centers at 295 K, accurate determination of valences was not possible. However, by observing the trend of spectral intensities and center shift for the nitrogen-bound and carbon-bound iron, respectively, at 90 K, valence mixing between the iron sites could be quantified. By accounting for valence mixing, the sum of iron valences agreed with the sodium content determined from elemental analysis. Without an agreement between the total valence sum and the determined composition, there exists uncertainty around the accuracy of the elemental analysis and vacancy content determination. Thus, this study offers one more stepping stone toward a more rigorous characterization of composition in PW, which will enable further optimization of properties for battery applications. More broadly, the approach is valuable for characterizing iron-based PBAs in applications where precise composition, valence determination, and control are desired.
Simulation of the Potential Suitable Distribution of the Endangered Cremastra appendiculata in China Under Global Climate Change
Authors: Ouyang Xianheng , Chen Anliang , Brien Strachan Garry , Mao Yangjun , Zuo Luying , Lin Haiping 
Published: July 2022

Predicting the spatial distribution of species in relation to suitable areas under global climate change could provide some references for conservation and long-term management strategies for the species. In this study, the MaxEnt was optimized by adjusting the feature combination and regulation magnification parameters with the ENMeval data package. Based on 127 Cremastra appendiculata spatial distribution locations and 14 environmental factors, the potential distribution areas of C. appendiculata under the present and future climate conditions (2050s, 2070s) were simulated, and the dominant environmental factors influencing the spatial distribution of C. appendiculata were analyzed. The feature combination (FC) and the regularization multiplier (RM) were selected as per the Akaike information criterion (AIC). The model showed complexity and degree of over-fitting (delta AICc = 0, omission rate = 0.106, the difference in the curve values between the training and testing areas was 0.021) after establishing the optimal model (FC = LQH and RM = 2.5), and the results indicated that the optimal model performed well in simulating the potential spatial distribution of C. appendiculata (the area under the receiver operating characteristic curve = 0.933). The results showed that the suitable habitat of C. appendiculata currently in China is 187.60 × 104 km2, while the highly suitable habitat is 118.47 × 104 km2, the moderately suitable habitat is 53.25 × 10 4 km2, and the poorly suitable habitat is 15.88 × 104 km2. There is an increasing trend in the suitable habitat of C. appendiculata under six climate scenarios, including SSP1-2.6, SSP2-4.5, and SSP5-8.5 in the 2050s and the 2070s, and that habitat will extend to the northwest as a whole. The highly suitable habitat of C. appendiculata in nature reserves is 0.47 × 104 km2; consequently, there is a large gap in the protection of C. appendiculata. The distribution of C. appendiculata was influenced by the temperature, precipitation, and normalized vegetation index.
Barriers and Facilitators for Population Genetic Screening in Healthy Populations: A Systematic Review
Authors: Shen Emily C. , Srinivasan Swetha , Passero Lauren E. , Allen Caitlin G. , Dixon Madison , Foss Kimberly , Halliburton Brianna , Milko Laura V. , Smit Amelia K. , Carlson Rebecca , Roberts Megan C. 
Published: July 2022

Studies suggest that 1–3% of the general population in the United States unknowingly carry a genetic risk factor for a common hereditary disease. Population genetic screening is the process of offering otherwise healthy patients in the general population testing for genomic variants that predispose them to diseases that are clinically actionable, meaning that they can be prevented or mitigated if they are detected early. Population genetic screening may significantly reduce morbidity and mortality from these diseases by informing risk-specific prevention or treatment strategies and facilitating appropriate participation in early detection. To better understand current barriers, facilitators, perceptions, and outcomes related to the implementation of population genetic screening, we conducted a systematic review and searched PubMed, Embase, and Scopus for articles published from date of database inception to May 2020. We included articles that 1) detailed the perspectives of participants in population genetic screening programs and 2) described the barriers, facilitators, perceptions, and outcomes related to population genetic screening programs among patients, healthcare providers, and the public. We excluded articles that 1) focused on direct-to-consumer or risk-based genetic testing and 2) were published before January 2000. Thirty articles met these criteria. Barriers and facilitators to population genetic screening were organized by the Social Ecological Model and further categorized by themes. We found that research in population genetic screening has focused on stakeholder attitudes with all included studies designed to elucidate individuals’ perceptions. Additionally, inadequate knowledge and perceived limited clinical utility presented a barrier for healthcare provider uptake. There were very few studies that conducted long-term follow-up and evaluation of population genetic screening. Our findings suggest that these and other factors, such as prescreen counseling and education, may play a role in the adoption and implementation of population genetic screening. Future studies to investigate macro-level determinants, strategies to increase provider buy-in and knowledge, delivery models for prescreen counseling, and long-term outcomes of population genetic screening are needed for the effective design and implementation of such programs.Systematic Review Registration: https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42020198198