bluuebunny/crossref_metadata_2025_split huggingface dataset:
Potential indicators for hyperparathyroidism progression: Calcium, phosphorus, alkaline phosphatase, 25 hydroxyvitamin D and hemoglobin
Authors: Zhang Liuyang , Chen Yong , Ao Yazhou 
Published: May 2022

Purpose: To compare the differences in perioperative biochemical indices between patients with primary hyperparathyroidism (PH) and secondary hyperparathyroidism (SH).
Methods: One hundred and ten patients with hyperparathyroidism who were treated in The Affiliated Hospital of Chengde Medical University, from June 2016 to April 2021, were enrolled and divided into two groups, viz, PH group (50 patients) and SH group (60 patients). Automatic biochemical analyzer was used to determine the levels of calcium, phosphorus, alkaline phosphatase and 25-hydroxyvitamin D, while hemoglobin was determined by liquid chromatography coupled with tandem mass spectrometry in the perioperative period.
Results: Compared to PH group, SH group had higher levels of indicators (p < 0.05). There were significant differences in body mass index (BMI), somatic cell index and blood albumin in patients from 18 to 70 years (p < 0.05). BMI and blood albumin increased significantly with age (p < 0.05). The complication rate was higher in SH than PH group (p < 0.05). The scores of pruritus and bone pain of patients after surgery were lower than those before the operation (p < 0.05). Blood calcium levels increased significantly with age, while ALP and iPTH levels decreased significantly (p < 0.05). SH group showed lower scores of physiological, emotional, social, and cognitive functions than PH group (p < 0.05).
Conclusion: Patients with PH and SH have differences in perioperative biochemical indicators. Furthermore, the levels of calcium, phosphorus, alkaline phosphatase, 25 hydroxyvitamin D, and hemoglobin may be used as indicators of disease progression, and this may facilitate the development of suitable therapeutic measures.
Identification of the components and molecular targets of Guanxin Danshen Dripping Pills for ps ycho cardiology treatment based on network pharmacology and ultra performance liquid ch r omatography tandem mass spectrometry
Authors: Zhang Guanying , Hu Yeqing , Huang Yuqing , Liu Wanqing , Qian Zixuan , Lin Shirong , Yang Tao , Huang Jihan 
Published: May 2022

Purpose: To explore the molecular targets of Guanxin Danshen Dripping Pills (GXDS) in regulating psycho-cardiology disease through identifying its components by UPLC-MS/MS and network pharmacology approach.
Methods: Ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) was adopted to determine GXDS’ main constituents. SwissTargetPrediction and the similarity ensemble approach were employed to predict possible molecular targets. Targets for psycho-cardiological disease were identified from the GeneCards database. The GXDS components overlapping these targets were identified using Venny web tool (version 2.1.0). Functional enrichment analysis was performed using Gene Ontology knowledgebase, while enrichment analysis of Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways was undertaken. In Cytoscape, target-pathway, pathway-target, and compound-target networks were constructed.
Results: Among the 37 chemical components identified through UPLC-MS/MS, 19 were combined with 63 psycho-cardiological disease targets, which were subjected to gene ontology enrichment analysis to obtain terms corresponding to the sub-ontologies of cellular components, molecular functions, and biological processes (30, 84, and 1188, respectively). Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis revealed 109 related pathways.
Conclusion: This study identified GXDS components, combined them through network pharmacology analysis, and explored the material basis and targets of the therapeutic effect of GXDS on psycho-cardiological disease. Thus, GXDS is a potential candidate for use in the clinical treatment of psycho-cardiological diseases
Social media use for medicine information seeking behaviour among undergraduate students via the prism of the innovation decision process
Authors: Ola-Olorun Omoniyi J , Oyeniran Olajire J , Jegede Ayodapo O , Ogunlade Bamidele O 
Published: May 2022

Purpose: To assess the level of adoption of social media for medical information-seeking behaviour (MISB) among students of Obafemi Awolowo University, Nigeria based on the prism of Roger’s innovation-decision process theory.
Methods: The study was a cross-sectional survey of 429 students. Primary data were collected with a set of questionnaires comprising two main sections which sought to elicit information, first, on the adoption level of social media for medicine information employing a Likert-type scale with five alternative responses and weighting scores of 1 - 5, and second, on use of social media for MISB on a dichotomous (yes/no) scale. Collected data were analysed with descriptive and inferential statistics at 5 % level of significance.
Results: The results show that adoption of social media tools for sourcing medicine information among the students was at a persuasion level (MWA 2.10) and correlates with the finding on the dichotomous scale that they were barely (28.7 %) using the tools.
Conclusion: Social media for medicine information-seeking among students of OAU have not been effectively adopted and their use is infrequent. Furthermore, studies on the use of social media may be better assessed using the innovation-decision theory process model rather than a simple dichotomous scale.
Protective effect of epalrestat on peripheral nerves in rats with diabetic peripheral neuropathy via NF κB pathway
Authors: Huang Jie , Tan Xinghua 
Published: May 2022

Purpose: To study the protective effect of epalrestat on peripheral nerves in rats with diabetic peripheral neuropathy (DPN).
Methods: A total of 36 Sprague-Dawley rats were randomly divided into normal, model, and epalrestat groups, each containing 12 rats. The morphology of the neurons was assessed using hematoxylin-eosin (H&E) staining. The expressions of B-cell lymphoma-2 (Bcl-2), and Bcl-2 associated X protein (Bax) were determined via immunohistochemistry. The relative protein expressions of NF-κB and Caspase3 were determined via Western blotting, and apoptosis was determined using terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) assay.
Results: The morphology of the neurons was clear and intact in the normal group, disordered and destroyed in the model group, and was improved in the epalrestat group. The other two groups had a significantly higher positive expression of Bax and a significantly lower positive expression of Bcl-2 than the normal group (p < 0.05), while the epalrestat group had a significantly lower positive expression of Bax, and a significantly higher positive expression of Bcl-2 than the model group (p < 0.05). Furthermore, the protein expressions of NF-κB and Caspase3 were increased in other groups compared with normal group (p < 0.05), while they declined in epalrestat group compared with model group (p < 0.05). The apoptosis rate was significantly lower in epalrestat group than in model group (p < 0.05).
Conclusion: Epalrestat inhibits neuronal apoptosis by suppressing the NF-κB signaling pathway, thereby exerting a neuroprotective effect in DPN rats. Further studies would be required to validate the molecular mechanism.
Perm Institute of Railway Transport: the path is 140 years long
Authors: Timolyanova N. A. 
Published: May 2022

The study of such an important issue as history occupies a dominant place in our lives. Awareness and selfdetermination are made up of those historical facts that form the basis of any social phenomenon. It is for this reason that it is important to study and present the history of the university, using museum sources and historical literature.Perm Institute of Railway Transport — a branch of the Ural State University of Railway Transport has come a long way from college to institute, from a two-story building to a student complex, consisting of two buildings and dormitories.The fate of the institute echoes the events taking place in the country: strikes in the early 20th century, revolutions, the Civil War, World War II, the post-war years, the “dashing” 90s, the golden zero.The teaching staff is changing, the technical base is expanding, specialties and forms of education are being transformed. But one thing remains unchanged — the training of highly qualifi ed employees for the needs of the railway. Throughout this time, close cooperation with the employer was carried out.The Perm Institute of Railway Transport has a rich history, this year marks the 140th anniversary of the institute. Analysis and study of the past, summing up, identifying achievements contribute to building a course for the future.
Overseas Hoisting and Handling Equipment Innovations
Authors: Tiverovsky V. I. 
Published: May 2022

Digitalization and automation determine the main trends in the development of logistics at the present stage. The same trends set the way for the improvement of handling equipment, as the basis for the development of logistics and mainly internal logistics. An important place in the implementation is occupied by fl oor vehicles, especially transport systems with fl oor carts operating without drivers. The innovative development of these systems is considered. The relevance of automating the determination of the dimensions and mass of cargo is noted, data are given on the systems in which these functions are implemented. The use of robots, including collaborative ones, in lifts, cranes and other types of equipment is described. Examples of the use of new technical means for IT-technologies are shown.Innovations in handling and storage equipment abroad are determined by the requirements of digitalization and automation. This also provides for the introduction of some IT-technologies where automation is ineff ective due to the small amount of work or for reasons of economic effi ciency.Automatic cranes, various types of lifts, automatic sorting systems, automatic systems and means for measuring the mass and size of goods, and other equipment have been widely used.All these innovations create the conditions for dynamic, digitized, intelligent warehouse logistics and modern internal transport in industrial plants and warehouses.Foreign innovative experience should be used in our country in the implementation of promising projects and programs in the fi eld of transport and logistics.
Distance educational technologies in the organization of independent work of students
Authors: Zorkova E. M. , Kalashnikova T. N. , Shesternina V. V. 
Published: May 2022

The organization of independent work of students in the process of studying professional modules in the specialty 23.02.01 “Organization of transportation and transport management (by type)” with the help of electronic training courses is considered. Educational institutions determine the forms and requirements for the organization and control of independent work of students in an educational organization.These requirements are developed and approved in the form of regulations or guidelines for organizing independent work. Teachers of the Primorsky Institute of Railway Transport are actively using an automated distance education system using the LMS Moodle virtual environment. The platform provides a space for collaboration between teachers and students. In Moodle, various options are available for assessing student performance, the results of independent work, for example, learning new material, testing. Describes the use of course elements such as “Lecture”, “Assignment”, “Glossary”, “Seminar”, “Test”. The analysis of the features of independent work of students of Primorsky Institute of Railway Transport in the distance learning system, as well as methods of its control, was carried out.A lot of work has been done at Primorsky Institute of Railway Transport to create electronic teaching aids widely used in the educational process and place them in the electronic educational environment of the institute. The main value of methodical electronic educational resources is the availability for students of all forms of education subscribed to this training course.
Methodology of formation of cognitive independence of students
Authors: Novikov S. A. 
Published: May 2022

The task of Russian education today is the preparation of a highly qualifi ed specialist who is competent not only in the professional fi eld of activity, but also in related fi elds. He must also be an active, enterprising and independent person, ready for lifelong learning. This is important, since the success in the career of each person largely depends on his ability and desire for self-development and self-improvement.The problems of the formation of the cognitive independence of the student at the present stage of the development of society are investigated, the necessity and relevance of cognitive independence for the student is substantiated. The defi nitions of the concepts of “cognitive independence”, “self-education” are presented. Motives, forms of formation of independence are described, possible results of the formation of cognitive independence are indicated.The potential for self-education is considered as a leading and eff ective means of forming the cognitive readiness of a future specialist for professional activity. An attempt is made to name all the stages of the formation and development of the skill of the student’s cognitive independence.The stages of formation of readiness for professional self-education, components of educational strategies of self-education are singled out. The most important component of social and emotional learning is self-regulation. Self-regulation is the ability to control attention, thoughts and emotions. The conclusion is made about the need to form this skill in modern realities.
Evaluation of DNA methylation of MAP9 gene in breast cancer as epigenetic biomarker
Authors: Rasheed Marrib N. 
Published: May 2022

Introduction and Aim: The DNA methylation is involved in the regulation of gene activity and abnormal DNA methylation is associated with various diseases, including cancer. MAP9 (Microtubule-Associated Protein 9) gene methylation was investigated as a potential epigenetic biomarker for cancer in this work. The results were published in Cancer Research.

Materials and Methods: The present study was on 40 breast cancer samples and 20 healthy samples to identify diagnosis biomarkers for breast cancer. DNA was extracted from the whole blood of breast cancer patients and healthy samples and were converted to bisulfite by using EpiTect Fast DNA Bisulfite Kit –Part 1 from Qiagen company. Then used Qia gene methylation kit to identify methylated site an epigenetic marker (MAP9) using HRM software in RT-PCR.

Results: The findings of the present investigation revealed that the methylation of the MAP9 gene in breast cancer patients were 28 (70%) compared to healthy patients 2 (10%) at a significant difference (P<0.01).

Conclusion: The MAP9 gene is hypermethylated in breast cancer patients, and it has the potential to be exploited as a molecular biomarker for the detection of breast cancer.
A study on protective effect of Piper longum and Hybanthus enneaspermus on glucose induced diabetic cataract in cultured goat lens
Authors: Katta Ashok , M Murugan 
Published: May 2022

Introduction and Aim: The maintenance of protein redox status, thought to be largely responsible for cell survival and function, may be the outcome of oxidative events, antioxidant protection and degradation of damaged proteins. Diabetes has been one of the substantial predisposing factors of cataract. Cataractogenesis in diabetes is mainly due to generation of free radicals causing oxidation of long-lived proteins. phytonutrient isolated from medicinal herbs are now proven to have great antioxidant & other therapeutic properties. The present study was done to understand the pathophysiology of diabetic cataract to formulate and develop novel and effective anticataract agents and to explore role of Piper longum and Hybanthus enneaspermus in the prevention of oxidative damage of lens proteins in glucose induced cataract.

Material and Methods: A total of 120 goat lenses were distributed into four groups of 30 each viz. Normal control, experimental diabetic cataract, experimental diabetic cataract + extract of Piper longum (0.25%), experimental diabetic cataract extract of H. enneaspermus (0.25%). Various study parameters measured in lens homogenates comprised malondialdehyde (MDA), total soluble lens proteins, and protein carbonyl level as a measure of lens protein oxidation.

Results: Both extract of Piper longum and H. enneaspermus showed significantly declined concentrations of protein carbonyl level, preserved total soluble proteins and decreased malondialdehyde (MDA) (p<0.001). P. longum aqueous seed extract performed better over H. enneaspermus.

Conclusion: It is concluded that aqueous extract of Piper longum and H. enneaspermus contains potent antioxidant compounds which shown protective role against cataractogenesis in the present.
Does dental x-ray cause oral keratosis?
Authors: Yanuaryska Ryna Dwi , Gracea Rellyca Sola 
Published: May 2022

Introduction and Aim: Ionizing radiation in dental imaging technology may cause cytotoxicity by means of changing the buccal mucosa cells and gingiva maturation pattern. Alteration of maturation pattern was often accompanied by increasing anucleated cells number that indicates keratosis. This study aimed to evaluate whether superficial keratosis also occurred after exposure to dental X-ray radiation.

Methods: The study samples consisted of 40 participants and were divided into two groups: exposed (patients who came in for taking analog/digital panoramic radiography or cone beam CT) and controlled (no radiography examinations). Each group contained ten individuals. Exfoliative cytology smears have been taken from the gingival and buccal mucosa before (or on day 0 for the control group) and 10 days post-exposure. The Papanicolaou approach was used to stain the cells. The anucleated cells in each glass slide have been then counted.

Results: No significant differences (p > 0.05) were observed in anucleated cell numbers between days 0 and 10 in both the controlled and exposed groups. The anucleated cell numbers also confirmed no significant difference between the gingiva and buccal mucosa.

Conclusion: Analog/digital panoramic radiography and CBCT exposure do not cause increases in anucleated cell numbers, so keratosis may not occur in patients exposed to dental X-ray radiation.
HomogWS-se: a century-long homogenized dataset of near-surface wind speed observations since 1925 rescued in Sweden
Authors: Zhou Chunlüe , Azorin-Molina Cesar , Engström Erik , Minola Lorenzo , Wern Lennart , Hellström Sverker , Lönn Jessika , Chen Deliang 
Published: May 2022

Abstract. Creating a century-long homogenized near-surface wind speed observation
dataset is essential to improve our current knowledge about the uncertainty and causes of wind speed stilling and recovery. Here, we rescued paper-based records of wind speed measurements dating back to the 1920s at 13 stations in Sweden and established a four-step homogenization procedure to generate the first 10-member centennial homogenized wind speed dataset (HomogWS-se) for community use. Results show that about 38 % of the detected change points were confirmed by the known metadata events, and the average segment length split by the change points is ∼11.3 years. Compared with the raw wind speed series, the homogenized series is more continuous and lacks significant non-climatic jumps. The homogenized series presents an initial wind speed stilling and subsequent recovery until the 1990s, whereas the raw series fluctuates with no clear trend before the 1970s. The homogenized series shows a 25 % reduction in the wind speed stilling during 1990–2005 than the raw series, and this reduction is significant when considering the homogenization uncertainty. The homogenized wind speed series exhibits a significantly stronger correlation with the North Atlantic oscillation index than that of the raw series (0.54 vs. 0.29). These results highlight the importance of the century-long homogenized series in increasing our ability to detect and attribute multidecadal variability and changes in wind speed. The proposed homogenization procedure enables other countries or regions to rescue their early climate data and jointly build global long-term high-quality datasets. HomogWS-se is publicly available from the Zenodo repository at https://doi.org/10.5281/zenodo.5850264 (Zhou et al., 2022).
Towards effective drought monitoring in the Middle East and North Africa (MENA) region: implications from assimilating leaf area index and soil moisture into the Noah-MP land surface model for Morocco
Authors: Nie Wanshu , Kumar Sujay V. , Arsenault Kristi R. , Peters-Lidard Christa D. , Mladenova Iliana E. , Bergaoui Karim , Hazra Abheera , Zaitchik Benjamin F. , Mahanama Sarith P. , McDonnell Rachael , Mocko David M. , Navari Mahdi 
Published: May 2022

Abstract. The Middle East and North Africa (MENA) region has experienced more frequent and severe drought events in recent decades, leading to increasingly pressing concerns over already strained food and water security. An effective drought monitoring and early warning system is thus critical to support risk mitigation and management by countries in the region. Here we investigate the potential for assimilation of leaf area
index (LAI) and soil moisture observations to improve the representation of the overall hydrological and carbon cycles and drought by an advanced land surface model. The results reveal that assimilating soil moisture does not meaningfully improve model representation of the hydrological and biospheric
processes for this region, but instead it degrades the simulation of the interannual variation in evapotranspiration (ET) and carbon fluxes, mainly due to model
weaknesses in representing prognostic phenology. However, assimilating LAI leads to greater improvement, especially for transpiration and carbon fluxes, by constraining the timing of simulated vegetation growth response to evolving climate conditions. LAI assimilation also helps to correct for the erroneous interaction between the prognostic phenology and irrigation during summertime, effectively reducing a large positive bias in ET and carbon fluxes. Independently assimilating LAI or soil moisture alters the categorization of drought, with the differences being greater for more severe drought categories. We highlight the vegetation representation in response to changing land use and hydroclimate as one of the key processes to be captured for building a successful drought early warning system for the MENA region.