bluuebunny/crossref_metadata_2025_split huggingface dataset:
An experiment for electron-hadron scattering at the LHC
Authors: André K. D. J. , Bella L. Aperio , Armesto N. , Bogacz S. A. , Britzger D. , Brüning O. S. , D’Onofrio M. , Ferreiro E. G. , Fischer O. , Gwenlan C. , Holzer B. J. , Klein M. , Klein U. , Kocak F. , Kostka P. , Kumar M. , Mellado B. , Milhano J. G. , Newman P. R. , Piotrzkowski K. , Polini A. , Ruan X. , Russenschuk S. , Schwanenberger C. , Vilella-Figueras E. , Yamazaki Y. 
Published: January 2022

AbstractNovel considerations are presented on the physics, apparatus and accelerator designs for a future, luminous, energy frontier electron-hadron (eh) scattering experiment at the LHC in the thirties for which key physics topics and their relation to the hadron-hadron HL-LHC physics programme are discussed. Demands are derived set by these physics topics on the design of the LHeC detector, a corresponding update of which is described. Optimisations on the accelerator design, especially the interaction region (IR), are presented. Initial accelerator considerations indicate that a common IR is possible to be built which alternately could serve eh and hh collisions while other experiments would stay on hh in either condition. A forward-backward symmetrised option of the LHeC detector is sketched which would permit extending the LHeC physics programme to also include aspects of hadron-hadron physics. The vision of a joint eh and hh physics experiment is shown to open new prospects for solving fundamental problems of high energy heavy-ion physics including the partonic structure of nuclei and the emergence of hydrodynamics in quantum field theory while the genuine TeV scale DIS physics is of unprecedented rank.
Late time transition of Universe and the hybrid scale factor
Authors: Aydiner E. , Basaran-Öz I. , Dereli T. , Sarisaman M. 
Published: January 2022

AbstractIn this study, we propose an interacting model to explain the physical mechanism of the late time transition from matter-dominated era to the dark energy-dominated era of the Universe evolution and to obtain a scale factor a(t) representing two eras together. In the present model, we consider a minimal coupling of two scalar fields which correspond to the dark matter and dark energy interacting through a potential based on the FLRW framework. Analytical solution of this model leads to a new scale factor a(t) in the hybrid form $$a(t)=a_{0} (t/t_{0})^{\alpha } e^{ht/t_{0}}$$

a

(
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)

=

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0

(
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/

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)

α

e

h
t
/

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. This peculiar result reveals that the scale factor behaving as $$a (t) \propto (t/t_{0})^{\alpha }$$

a

(
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)

∝

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/

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0

)

α

in the range $$t/t_{0}\le t_{c}$$

t
/

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≤

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corresponds to the matter-dominated era while $$a(t) \propto \exp (ht/t_{0})$$

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∝
exp

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/

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)

in the range $$t/t_{0}>t_{c}$$

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>

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accounts for the dark energy-dominated era, respectively. Surprisingly, we explore that the transition from the power-law to the exponential expansion appears at the crossover time $$t_{0} \approx 9.8$$

t
0

≈
9.8

Gyear. We attain that the presented model leads to precisely correct results so that the crossover time $$t_{0}$$

t
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and $$\alpha $$
α
are completely consistent with the exact solution of the FLRW and re-scaled Hubble parameter $$H_{0}$$

H
0

lies within the observed limits given by Planck, CMB and SNIa data (or other combinations), which lead to consistent cosmological quantities such as the dimensionless Hubble parameter h, deceleration parameter q, jerk parameter j and EoS parameter w. We also discuss time dependent behavior of the dark energy and dark matter to show their roles on the time evolution of the universe. Additionally, we observe that all main results completely depend on the structure of the interaction potential when the parameter values are tuned to satisfy the zero energy condition. Finally, we conclude that interactions in the dark sector may play an important role on the time evolution and provides a mechanism to explain the late time transition of the Universe.
Software Hint-Driven Data Management for Hybrid Memory in Mobile Systems
Authors: Wen Fei , Qin Mian , Gratz Paul , Reddy Narasimha 
Published: January 2022

Hybrid memory systems, comprised of emerging non-volatile memory (NVM) and DRAM, have been proposed to address the growing memory demand of current mobile applications. Recently emerging NVM technologies, such as phase-change memories (PCM), memristor, and 3D XPoint, have higher capacity density, minimal static power consumption and lower cost per GB. However, NVM has longer access latency and limited write endurance as opposed to DRAM. The different characteristics of distinct memory classes render a new challenge for memory system design.
Ideally, pages should be placed or migrated between the two types of memories according to the data objects’ access properties. Prior system software approaches exploit the program information from OS but at the cost of high software latency incurred by related kernel processes. Hardware approaches can avoid these latencies, however, hardware’s vision is constrained to a short time window of recent memory requests, due to the limited on-chip resources.
In this work, we propose OpenMem: a hardware-software cooperative approach that combines the execution time advantages of pure hardware approaches with the data object properties in a global scope. First, we built a hardware-based memory manager unit (HMMU) that can learn the short-term access patterns by online profiling, and execute data migration efficiently. Then, we built a heap memory manager for the heterogeneous memory systems that allows the programmer to directly customize each data object’s allocation to a favorable memory device within the presumed object life cycle. With the programmer’s hints guiding the data placement at allocation time, data objects with similar properties will be congregated to reduce unnecessary page migrations.
We implemented the whole system on the FPGA board with embedded ARM processors. In testing under a set of benchmark applications from SPEC 2017 and PARSEC, experimental results show that OpenMem reduces 44.6% energy consumption with only a 16% performance degradation compared to the all-DRAM memory system. The amount of writes to the NVM is reduced by 14% versus the HMMU-only, extending the NVM device lifetime.
Mitigation of IL-1β, IL-6, TNF-α, and markers of apoptosis by ursolic acid against cisplatin-induced oxidative stress and nephrotoxicity in rats
Authors: Tripathi Pankaj , Alshahrani Saeed 
Published: January 2022

Background: Ursolic acid (UA) is a natural pentacyclic triterpenoid that is known for its benefits under several pathological conditions. Cisplatin (CP) is among the most preferred chemotherapeutic agents; however, its nephrotoxicity limits its clinical utility. Purpose: This study was aimed to determine the role of UA in the reduction of CP-induced nephrotoxicity and mitigation of pro-inflammatory cytokines and apoptosis in a rat model. Methodology: Male Wistar rats were randomized into vehicle control, CP (7.5 mg/kg), UA 10 mg/kg, and CP with UA 5 and 10 mg/kg groups. Kidney and blood samples were collected for assessment of renal function, measurement of pro-inflammatory cytokines, apoptosis markers, antioxidant activity, and tissue histology. Results: CP significantly increased the levels of serum Cr, BUN, and uric acid; it also induced histological damage reflecting the pathophysiology observed during nephrotoxicity. CP has also shown its pro-oxidant activity in kidney tissue because CP decreased the levels of GSH, SOD, and CAT; it increased the lipid peroxidation as measured by MDA content. In addition, CP significantly upregulated the activity of pro-inflammatory cytokines and expression of apoptotic markers, that is, there were increased levels of IL-1β, IL-6, TNF-α, caspase-3, and caspase-9. Two weeks of continuous treatment of UA showed significant recovery against CP-induced nephrotoxicity; UA decreased the levels of Cr, BUN, and uric acid and ameliorated histological damage. UA also downregulated the activities of IL-1β, IL-6, and TNF-α as well as expression of caspase-3 and caspase-9. Furthermore, CP-induced oxidative stress that was antagonized by UA—the levels of GSH, SOD, and CAT were significantly increased while MDA content was decreased. Conclusions: UA has a protective effect against CP-induced nephrotoxicity, which may be due to its antioxidant activity and mitigation of IL-1β, IL-6, TNF-α, and markers of apoptosis.
Introduction to the Themed collection: Public sector employment relations in turbulent times
Authors: O’Donnell Michael , Williamson Sue , Johnson Michael 
Published: January 2022

AbstractWe introduce a themed collection of articles examining how the public sector has responded to, and been impacted by, the COVID-19 crisis. Although the pandemic has affected the roles, functions, economies, governance and structures of public sectors, this themed collection focuses on public sector employment relations. Authors examine significant areas which have been subject to accelerated change stemming from the pandemic. Building on decades of public sector reform, these changes impact public sector enterprise bargaining, terms and conditions of employment, working arrangements and practices, and the relationship between public servants and their employer. The articles in this collection provide important insights into the longer-term influences of the COVID-19 pandemic for public sector workforces. The collection also raises questions around whether the positive lessons from this crisis can be sustained to help manage serious crises in the future, or whether the public sector will slip back into a state of unpreparedness.
Cavovarus With a Twist: Midfoot Coronal and Axial Plane Rotational Deformity in Charcot-Marie-Tooth Disease
Authors: An Tonya , Haupt Edward , Michalski Max , Salo Jari , Pfeffer Glenn 
Published: January 2022

Background: The cavovarus deformity of Charcot-Marie-Tooth (CMT) disease is often characterized by a paradoxical relationship of hindfoot varus and forefoot valgus. The configuration of the midfoot, which links these deformities, is poorly understood. Accurate assessment of 3-dimensional alignment under physiologic loadbearing conditions is possible using weightbearing computed tomography (WBCT). This is the first study to examine the rotational deformity in the midfoot of CMT patients and, thus, provide key insights to successful correction of CMT cavovarus foot. Methods: A total of 27 WBCT scans from 21 CMT patients were compared to control WBCTs from 20 healthy unmatched adults. CMT patients with a history of bony surgery, severe degenerative joint disease, or open physes in the foot were excluded. Scans were analyzed using 3-dimensional software. Anatomic alignment of the tarsal bones was calculated relative to the anterior-posterior axis of the tibial plafond in the axial plane, and weightbearing surface in the coronal plane. Results: Maximal rotational deformity in CMT patients occurred at the transverse tarsal joints, averaging 61 degrees of external rotation (supination), compared to 34 degrees among controls ( P < .01). The talonavicular joint was also the site of peak adduction deformity in the midfoot, with an average talonavicular coverage angle measuring 12 degrees compared with −11 degrees in controls ( P < .01). Conclusion: This 3-dimensional WBCT analysis is the first to isolate and quantify the multiplanar rotational deformity in the midfoot of CMT patients. Compared with healthy unmatched control cases, CMT patients demonstrated increased axial plane adduction and coronal plane rotation at the talonavicular (TN) joint. These findings support performing soft tissue release at the TN joint to abduct and derotate the midfoot as a first step for targeted deformity correction. Level of Evidence: Level III, retrospective case-control study.
Risk Factors of White Blood Cell Progression Among Patients With Chronic Lymphocytic Leukemia at Felege Hiwot Referral Hospital, Bahir Dar, Ethiopia
Authors: Addisia Gedam Derbew , Tegegne Awoke Seyoum , Belay Denekew Bitew , Muluneh Mitiku Wale , Kassaw Mahider Abere 
Published: January 2022

Background: Leukemia is a type of cancers that start in the bone marrow and produce a serious number of abnormal white blood cells. Bleeding and bruising problems, fatigue, fever, and an increased risk of infection are among symptoms of the disease. The main objective of this study is to identify the determinant of the progression rate of white blood cells among patients with chronic lymphocytic leukemia at Felege Hiwot Referral Hospital (FHRH), Bahir Dar, Ethiopia. Methods: A retrospective study design was conducted on 312 patients with chronic lymphocytic leukemia at FHRH, Bahir Dar, Ethiopia under treatment from 1 January 2017 to 31 December 2019. A linear mixed-effects model was considered for the progression of the white blood cell data. Results: The estimated coefficient of the fixed effect intercept was 84.68, indicating that the average white blood cell (WBC) count of the patients was 84.68 at baseline time by excluding all covariates in the model ( P-value <.001). Male sex ( β = 2.92, 95% confidence interval [CI] 0.58, 0.5.25), age ( β = .17, 95% CI 0.08, 0.28), widowed/divorced marital status ( β = 3.30, 95% CI 0.03, 6.57), medium chronic lymphocytic leukemia (CLL) stage ( β = −4.34, 95% CI −6.57, −2.68), high CLL stage ( β = −2.76, 95% CI −4.86, −0.67), hemoglobin ( β = .15, 95% CI 0.07, 0.22), platelet ( β = .09, 95% CI 0.02, 0.17), lymphocytes ( β = .16, 95% CI 0.03, 0.29), red blood cell (RBC) ( β = .17, 95% CI 0.09, 0.25), and follow-up time ( β = .27, 95% CI 0.19, 0.36) were significantly associated with the average WBC count of chronic lymphocytic leukemia patients. Conclusions: The finding showed that age, sex, lymphocytic, stage of chronic lymphocytic leukemia, marital status, platelet, hemoglobin, RBC, and follow-up time were significantly associated with the average WBC count of chronic lymphocytic leukemia patients. Therefore, health care providers should give due attention and prioritize those identified factors and give frequent counseling about improving the health of chronic lymphocytic leukemia patients.
Endovascular thrombectomy and repair of suprarenal inferior vena cava thrombosis: A case series
Authors: Vayani Omar R , Patel Manish J , Van Ha Thuong , Leef Jeffrey A , Lorenz Jonathan M , Millis Michael , Ahmed Osman 
Published: January 2022

Objectives The objective of this study is to document the combined use of catheter-based thrombectomy/thrombolysis with endovascular repair of high-risk segments of the inferior vena cava in the setting of iatrogenic and traumatic injuries. While the use of endovascular techniques to treat caval thrombosis is well documented and often preferred due to its minimally invasive nature, there is still little literature that focuses on the nuances related to injury of high mortality areas of the IVC as a result of major trauma, transplant, and other surgical interventions. Methods An IRB-approved retrospective review of all patients undergoing IVC thrombectomy was performed at a single tertiary care academic center between January 2018 and July 2021. Cases were subsequently selected based on those who underwent primary mechanical thrombectomy followed by endovascular stenting (or angioplasty). Among this cohort, four patients who underwent this procedure in the context of iatrogenic and traumatic injuries were included. Results All four patients undergoing primary mechanical thrombectomy followed by endovascular stenting (or angioplasty) due to IVC thrombus and/or stenosis were technically successful with immediate positive clinical outcomes. Conclusions Mechanical thrombectomy in conjunction with IVC recanalization via stenting may be a useful intervention with promising technical success and positive clinical outcomes for occlusive thrombosis and IVC stenosis.
Selection of risk assessment methods for osteoporosis screening in postmenopausal women with low-energy fractures: A comparison of fracture risk assessment tool, digital X-ray radiogrammetry, and dual-energy X-ray absorptiometry
Authors: Woisetschläger Mischa , Chisalita Simona , Vergara Marta , Spångeus Anna 
Published: January 2022

Objectives: Fracture liaison services are designed to identify patients needing osteoporosis treatment after a fracture. Some fracture liaison service designs involve a prescreening step, for example, fracture risk assessment tool (FRAX®). Another possible prescreening tools are bone mass density assessment in the acute setting. The aim of this study was to assess the effectiveness of prescreening tools. Methods: In the present prospective cohort study, women aged >55 years with a radius fracture were included. Patients were recruited at the emergency department after experiencing their fracture. All patients performed fracture risk assessment by fracture risk assessment tool, and bone mass density assessment by digital X-ray radiogrammetry and dual-energy X-ray absorptiometry (prescreening steps) as well as full routine evaluation at the osteoporosis unit (endpoint). The main outcome measures were sensitivity, specificity, predictive values, and area under the curve. Results: Forty-one women were recruited (mean age: 70 ± 8 years). Of these, 54% fulfilled the treatment indication criteria of osteoporosis after a full examination. Fracture risk assessment tool without bone mass density (cutoff ⩾ 15%) for prescreening patients had a high sensitivity (90%) but a low area under the curve (0.50) and specificity (16%). The highest area under the curve (0.73) was found prescreening with bone mass density assessment (dual-energy X-ray absorptiometry or digital X-ray radiogrammetry) having a sensitivity of 59%–86% and specificity of 61%–90%. Conclusion: This study, though small, raises questions regarding the effectiveness of using a prescreening step in fracture liaison services for high-risk individuals. In this cohort, FRAX® without bone mass density had a low precision, with a risk of both underestimating and overestimating patients requiring treatment. Bone mass density assessment in the acute setting could improve the precision of prescreening. Further investigations on the effectiveness and health economics of prescreening steps in fracture liaison services are needed.
Impact of motivational interviewing as a follow-up to an exercise intervention among women with or at risk for metabolic syndrome: A randomized controlled trial
Authors: Suire Kameron B , Peart Ashley , Kavookjian Jan , Wadsworth Danielle D 
Published: January 2022

Objectives: Women have a higher prevalence of metabolic syndrome than their male counterparts, and interventions should target women with or at risk for metabolic syndrome. The objective of this study was to compare two intervention strategies on long-term outcomes following the completion of an exercise intervention. Methods: Twenty-six women ( M age = 43.35 ± 9.03) with at least one risk factor for metabolic syndrome were randomized into either a motivational interviewing group ( n = 10) or self-regulation-based mobile messaging control group ( n = 16) as a 12-week follow-up to a 10-week, 30-session exercise intervention. Outcomes of interest were body fat percentage, bone mineral density, waist circumference, systolic blood pressure, diastolic blood pressure, triglycerides, high-density cholesterol, and fasting blood glucose. Results: Mixed ANOVAs revealed a significant effect for group × time for body fat percentage F(1, 24) = 8.30, p = 0.01, [Formula: see text] = 0.26, bone mineral density F(1, 24) = 6.68, p = 0.02, [Formula: see text] = 0.22, waist circumference F(1, 24) = 10.35, p = 0.01, [Formula: see text] = 0.30, triglycerides F(1, 24) = 5.06, p = 0.03, [Formula: see text] = 0.17, and systolic blood pressure F(1, 24) = 5.39, p = 0.03, [Formula: see text] = 0.18 all in favor of the motivational interviewing group after 12 weeks when compared to the self-regulation-based mobile messaging group. No significant effect for group × time was noted for diastolic blood pressure p = 0.36, [Formula: see text] = 0.04, high-density cholesterol p = 0.08, [Formula: see text] = 0.12, or fasting blood glucose p = 0.85, [Formula: see text] = 0.01 when comparing the motivational interviewing and self-regulation-based mobile messaging groups. Conclusions: Motivational interviewing may be a more impactful solution to extend the effects of exercise intervention studies compared to a self-regulation-based mobile messaging control group. Future interventions should focus on increasing sample size, utilizing more objective measures of body composition, utilizing booster sessions, and increasing the length of follow-up periods.
Treatment results of nondamaging retinal laser therapy in diabetic macular edema
Authors: Gültekin Burcu P. 
Published: January 2022

Background: Subthreshold nondamaging retinal laser therapy (NRT) provides a greater safety profile than conventional laser methods, but more data is needed on the efficacy and safety of subthreshold NRT in diabetic macular edema. Purpose: To evaluate the efficacy and safety of NRT for the treatment of clinically significant macular edema (CSME) that is partially responsive or resistant to intravitreal anti-vascular endothelial growth factor (anti-VEGF) treatment. Methods: This was a retrospective case series study. Fifty eyes of 38 diabetic patients with CSME previously treated with at least 6-monthly intravitreal bevacizumab injections with/without intravitreal Ozurdex therapy were evaluated. The patients received 577-nm yellow wavelength laser therapy with PASCAL laser system (Topcon Medical Laser Systems, Santa Clara, CA, USA). Best-corrected visual acuity (BCVA) and central subfield thickness (CST) were evaluated before and 1, 3, 6, 12 and 24 months after laser treatment. Results: Baseline mean CST was 368.06 ± 86.9 µm. The mean CST values at the 1-, 3-, 6-, 12-, and 24-month visits were 336.93 ± 79.8, 352.40 ± 113.5, 336.36 ± 109.3, 325.10 ± 104 µm, and 310.08 ± 84.7 µm, respectively. The mean CST decreased significantly at the first ( p = 0.002) and second year visits ( p < 0.001) when compared with pretreatment values. Although visual acuity was improved at the first year compared with baseline, this difference was not statistically significant ( p = 0.03). There was no significant difference in visual acuities between pretreatment and posttreatment visits. During 24-month follow-up, while 37 eyes were treated with [mean: 5.7 ± 3.4 (1–14)] intravitreal anti-VEGF injections, 3 eyes were administered single-dose intravitreal steroids. Additional intravitreal injections were not required in 10 (20%) eyes. Conclusion: NRT is effective by itself or in combination with anti-VEGF agents in diabetic macular edema that is partially responsive or resistant to previous intravitreal injections. T role in treating this disorder should be assessed in more detail with prospective controlled studies.