bluuebunny/crossref_metadata_2025_split huggingface dataset:
Combined anti-mediator therapy for severe destructive forms of acute necrotizing pancreatitis in rats
Authors: Firsova Tatiana I. , Alekhin Sergey A. , Nazarenko Dmitry P. , Danilenko Lyudmila M. , Chub Antonina G. , Malyutina Elena S. , Lazareva Tatyana Yu. , Druzhikin Leontiy V. 
Published: July 2022

Introduction: Inflammatory mediators play a major role in pathogenesis of acute pancreatitis with TNF (tumor necro­sis factor) as the most important one. Development of effective combined therapy could help to decrease tissue damage, improve results and, finally, diminish the mortality rate in this severe pathology.
Materials and methods: All the studies were performed on 120 female white Wistar rats, weighing 250±25g. Acute pancreatitis reproduced by an intracanalicular injection of bile salts compound.
Results and discussion: The data obtained in the course of the study on the pronounced pancreatoprotective effect of infliximab are explained by its key role in the onset of the systemic inflammatory response, and, therefore, with the blockade of tumor necrosis factor alpha in the early stages, there is no pronounced secondary damage to the pancreas, which is reflected in a significant decrease in edema from 4.87±0.03 in the model up to 2.75±0.04, and as a conse­quence, an improvement in the blood supply of the acinar tissue from 182.38±15.92 PU up to 287.92±14.64 PU, which is expressed in a decrease in the zones of necrosis and in a decrease in mortality and, finally, efficiency coefficient from 13480.000 to 4283.348. A selective blocker of cysteinyl leukotrienes has a less pronounced protective reaction against damage to pancreatocytes, but to a much greater extent than octreotide. That is expressed by changes in the efficiency coefficient to the level of 8621.18 in montelukast group and 12767.30 in octreotide group, respectively. On the other hand, the effect of the use of infliximab does not surpass that of montelukast, and their combined use has a pronounced additive effect, which is proved by the efficiency coefficient at the level of 2390.33. This reaction is explained by the fact that TNF alpha-mediated pathway of activation of leukotriene biosynthesis is the main, but not the only one.
Conclusion: The combined anti-mediator therapy provides a great opportunity to improve the standard therapy of acute pancreatitis.
Le concept d’intégration, effet essentiellement secondaire de la déségrégation raciale ?
Authors: Bessone Magali 
Published: July 2022

L’article se propose dans un premier temps de comparer les arguments d’Elizabeth Anderson sur l’intégration comme impératif de justice et ceux d’Iris Marion Young qui critiquent l’idéal d’intégration et lui préfèrent un idéal d’inclusion comme « solidarité différenciée ». Il procède dans un second temps à un test des arguments promouvant ou critiquant l’intégration en les (dé)plaçant dans un contexte français, où le concept relève d’un champ sémantique et d’une sociohistoire très différents de ceux du contexte nord-américain. L’article proposera, dans ce contexte, une défense qualifiée du concept d’intégration, conçu non comme un « impératif » ni un « idéal » mais plutôt comme un « effet essentiellement secondaire » de la déségrégation raciale.
La démocratisation effective de la société
Authors: Gautier Claude 
Published: July 2022

La constitution des « publics » chez Dewey [1927] et la délibération inclusive chez Young [2000] visent la résolution d’un problème analogue, celui de la démocratisation effective de la société. Pour y parvenir, il faut, de part et d’autre, revenir au concept politique de « groupe » et le définir non pas ontologiquement – le critère d’identité par exemple – mais fonctionnellement comme une forme opératoire de structuration et de représentation d’intérêts communs. L’une des conditions de possibilité d’une telle approche des « groupes » suppose cependant la construction d’un savoir partagé. On montrera que cette condition demeure problématique dans sa réalisation et que, par conséquent, les difficultés auxquelles se heurtaient Dewey à propos des « publics » se retrouvent dans la théorie youngienne de la démocratie inclusive.
La perception du risque de mise en cause du fonctionnaire de terrain influe-t-elle sur le style d’inspection ?
Authors: Klijn Erik Hans , Eshuis Jasper , Opperhuizen Alette , de Boer Noortje 
Published: July 2022

Existe-t-il une relation entre le style d’inspection et la perception du risque de mise en cause chez les fonctionnaires de terrain ? Dans cet article, nous répondons à cette question en nous appuyant sur une enquête ( n = 507) réalisée auprès d’inspecteurs de l’autorité néerlandaise de la sécurité des aliments et des produits. Nous avons inclus leur perception de l’attention des médias sur leur travail en tant que facteur pouvant influer sur leur perception du risque de mise en cause et leur style d’inspection. Trois dimensions du style d’inspection ont été retenues à partir de recherches antérieures : légaliste, facilitante et accommodante. Selon nos observations, lorsque les inspecteurs perçoivent un risque de mise en cause plus élevé, ils adoptent un style légèrement moins légaliste et plus accommodant. Ils agissent alors d’une manière un peu moins formelle et rigide (moins légaliste) et prenant plus en compte l’avis des pairs (plus accommodante). Toutefois, la perception de l’attention des médias n’a pas eu d’influence significative sur le style d’inspection. Remarques à l’intention des praticiens Lorsque les inspecteurs perçoivent un risque de mise en cause plus élevé, ils ont tendance à accorder plus d’attention à l’avis de leurs pairs (autres inspecteurs, supérieurs hiérarchiques, etc.). Le risque de mise en cause ne conduit pas à l’adoption d’un style d’inspection plus formel. L’attention des médias ne joue pas un rôle important sur l’augmentation de la perception du risque de mise en cause chez les inspecteurs. Ce risque de médiatisation et de mise en cause est moins important que celui auquel les responsables politiques sont souvent exposés. Cela peut être lié au fait que le travail des inspecteurs, en tant que fonctionnaires de terrain, est moins visible pour le grand public (et les médias).
Une extension des exemptions : des changements systémiques dans le droit et les politiques de l’Union européenne
Authors: Bartha Ildiko , Horváth Tamás M. 
Published: July 2022

Les règles sur les services d’intérêt général autorisent des exceptions au droit du marché intérieur de l’Union européenne. Ces exceptions restent-elles vraiment dans les limites de la libre concurrence ? Aujourd’hui, cette question ne semble pas indépendante du risque de considérations politiques directes influençant le marché des services publics. Cette tendance peut se traduire par des mesures législatives ou administratives nationales susceptibles d’aller à l’encontre de l’esprit des objectifs initiaux de l’intégration de l’Union européenne. Le droit matériel et procédural de l’Union européenne ne semble pas soulever d’obstacles inévitables à ces démarches. Dans le contexte du cadre réglementaire de l’Union européenne pour les services d’intérêt général, notre recherche porte sur les résultats d’une analyse d’une base de données d’affaires judiciaires de l’Union européenne qui met en évidence les défis et les menaces des récents instruments nationaux d’organisation du secteur public pour le fonctionnement du marché intérieur de l’Union européenne et les règles de concurrence. Remarques à l’intention des praticiens Le rôle des États, que ce soit par l’évolution de leur influence réglementaire ou par des interventions économiques directes, a subi des changements au cours des 15 dernières années d’intégration européenne. Le renforcement du populisme et les virages vers l’intolérance trouvent peut-être leur origine dans la redéfinition du rôle des États membres dans l’intégration à travers l’activisme des gouvernements radicaux et/ou des pouvoirs politiques, pas seulement dans le monde politique. Cet article porte sur la manière dont les risques de cette évolution se retrouvent dans les politiques sectorielles des services publics.
Que peut faire un thérapeute familial dans les séparations conjugales conflictuelles ?
Authors: Delage Michel 
Published: July 2022

Les séparations conjugales sont souvent conflictuelles et ce sont tout particulièrement les enfants qui sont l’enjeu de ces conflits. Il s’agit ici de présenter les enjeux et les difficultés des séparations en utilisant la référence théorique de l’attachement. Du côté des adultes, l’insécurité relationnelle en rapport avec les conflits rend difficile la claire séparation des places et des rôles relevant de la conjugalité et celles relevant de la parentalité. Du côté des enfants, il peut être question de blessure d’attachement, de conflit d’attachement ou de « divorce ». Une clarification des conduites thérapeutiques est ensuite tentée, rendue toujours difficile quand les procédures judiciaires se prolongent et se complexifient.
Les ambivalences de Nietzsche
Authors: Marton Scarlett 
Published: July 2022

Les réflexions de Nietzsche sur les femmes n’ont pas une place marginale dans son œuvre ; elles ne sauraient se réduire à des préférences personnelles et moins encore à des égarements ponctuels. Bien au contraire, elles s’inscrivent dans son entreprise philosophique et sont en étroite relation avec les thèmes centraux de sa pensée.

Examiner les images de femmes que Nietzsche construit et les rôles qu’il leur accorde, étudier la façon dont il se sert de la typologie dans ses analyses de figures féminines, soulever la question de savoir pourquoi il crée des personnifications féminines d’entités abstraites, s’interroger sur ses positions vis-à-vis des femmes émancipées, comprendre les raisons qui le conduisent à combattre frontalement les femmes de lettres : voilà le fil conducteur de cette enquête. À partir d’une lecture immanente des textes de Nietzsche, Scarlett Marton met en relief les ambivalences multiples et variées qui caractérisent ses prises de position à l’égard des femmes : elles concernent le comportement des femmes mariées face aux esprits libres, l’attitude des femmes aimantes vis-à-vis de leurs amants, les traits des femmes bien-aimées de Zarathoustra, comparés à ceux des femmes seulement humaines. En définitive, quand il traite des femmes émancipées, Nietzsche ne témoigne plus d’aucune ambivalence. Il retrouve le geste d’exclusion caractéristique de la philosophie des temps modernes.
Este país é para velhos ? Migrações e envelhecimento em Portugal
Authors: Azevedo Liliana 
Published: July 2022

O artigo relaciona o envelhecimento demográfico com dinâmicas migratórias que ganharam amplitude na última década e que para ele concorrem : o regresso de migrantes portugueses/as reformados/as, por um lado, e, por outro, a imigração de reformados/as estrangeiros/as, na sua maioria provenientes da Europa. Tendo por base dados de diversas fontes (literatura, estatísticas e uma pesquisa de terreno sobre a transição para a reforma de migrantes portugueses/as na Suíça), compara-se os motivos e condições de fixação em Portugal de dois grupos de migrantes reformados/as. São abordados aspetos como a fiscalidade, a distribuição geográfica, a saúde e o impacto económico e salientadas semelhanças e diferenças entre migrantes reformados/as portugueses/as e estrangeiros/as. O artigo conclui ser necessária mais investigação no domínio das múltiplas e complexas intersecções entre envelhecimento e migrações, dada a escassez de estudos sobre esta matéria em Portugal e a manifesta ausência de conhecimento científico para sustentar políticas públicas.
Use of Music for Newborns After Cardiac Surgery: A Pilot Study
Authors: Sorensen Angela , Engstrand Shannon , Connor Jean A. 
Published: July 2022

Background
Music can benefit the neurodevelopmental and clinical care of newborns in the neonatal intensive care unit. Newborns in the cardiac intensive care unit experience similar stressors to those in the neonatal intensive care unit, but music therapy has not been widely studied in the cardiac intensive care unit population.

Objective
To explore the feasibility of implementing nurse-led music therapy in a cohort of newborns recovering from cardiac surgery in the cardiac intensive care unit.

Methods
Lullabies were prerecorded and played for 20 minutes, 2 times per day. Bedside nurses recorded several metrics at designated times during the 1 hour surrounding the music therapy and were asked about the ease of initiating the therapy and their perception of any benefit to the newborns. Parents were invited to complete a 9-question Likert survey exploring their perception of and satisfaction with the music therapy.

Results
Nurse-led music therapy was initiated in 44 of 50 eligible shifts (88%) for the 8 newborns who successfully completed the study. The newborns’ physiological status remained stable throughout the music therapy sessions. None of the newborns experienced adverse events related to music therapy. All nurses (100%) reported that the music therapy was easy to administer. Parents “agreed” or “strongly agreed” that they were satisfied with the music therapy provided to their newborns.

Conclusion
Nurse-led music therapy was highly feasible for hemodynamically stable newborns recovering from cardiac surgery. Parents and nursing staff responded positively to the music therapy.
Quantitative evaluation of apically extruded debris during root canal preparation with reciprocating single file system, continuous rotary multiple file system and manual technique
Authors: Mohana Pratima , Abraham Dax , Gurawa Alka , Gupta Alpa , Chauhan Parul , Singh Arundeep , Jala Sucheta 
Published: July 2022

Aim:
The aim of the study is to evaluate and compare the quantity of apical debris extrusion from the root canals during biomechanical preparation by various rotary (reciprocating, Protaper Next [PTN] continuous) and manual hand filing system and by means of Crown-Down and Step Back techniques.

Materials and Methods:
Eighty mature, human mandibular premolars with single canals were randomly divided into four groups of twenty teeth each. Each group was instrumented using one of the four instrumentation systems: Group A: WaveOne, Group B: PTN, Group C: Hand file with Crown Down, Group D: Hand file with Step Back. Extruded debris was collected in preweighed Eppendorf tubes and the extruded irrigant was evaporated. The weight of the dry extruded debris was established by comparing the pre and post-instrumentation weight of Eppendorf tubes for each group.

Results:
Mean comparison of groups in different instrumentation by ANOVA presented that hand file with Step-Back technique is showed maximum amount of apical extrusion debris and continuous rotary file system showed the minimum amount of extrusion debris (P < 0.001).

Conclusions:
The current ex vivo study demonstrated reciprocating single file WaveOne and continuous rotary multiple file system lead to significantly less debris extrusion than manual hand file techniques. Reciprocating single file WaveOne extruded more debris than continuous rotary PTN multiple file system. More amount of debris was extruded in the group with Step-Back hand filing than Crown-Down technique.
Evaluation of shear bond strength of e-mineral trioxide aggregate and biodentine with glass ionomer cement
Authors: Hiremath Hemalatha , Solanki Aishwarya Singh , Trivedi Shivangi , Verma Devansh 
Published: July 2022

Aim:
The aim of this study was to evaluate the shear bond strength of glass ionomer cement (GIC) with e-mineral trioxide aggregate (MTA) and Biodentine when placed immediately and after initial set.

Materials and Methodology:
Forty acrylic blocks with 2-mm height and 5-mm diameter central holes were prepared and randomly divided into two equal groups (n = 20). Group A (n = 20) and Group B (n = 20) were filled with E-MTA and Biodentine, respectively. These groups (n = 20) were further divided into two subgroups each; subgroup A1 (n = 10) and A2 (n = 10) were the placement of GIC immediately over freshly mixed e-MTA and after initial set e-MTA, respectively, subgroup B1 (n = 10) and B2 (n = 10) were the placement of GIC immediately over freshly mixed Biodentine and after initial set Biodentine, respectively. All the samples were later subjected to UTM for shear bond strength test.

Results:
The highest shear bond strength was recorded with subgroup B1 were the placement of GIC immediately over freshly mixed Biodentine, i. e., (18.72 MPa) and lowest with subgroup A2 placement of GIC after initial set MTA (5.96MPa). The shear bond strength of GIC condensed over freshly mixed e-MTA (subgroup A1) shows higher mean value then after initial set MTA (subgroup A2); however, SBS was highest in the placement of GIC immediately over freshly mixed Biodentine (subgroup B1).

Conclusion:
Within the limitation of this in vitro study, it can be concluded that freshly mixed Biodentine can be restored immediately with GIC.
Morphological and Anthropometrical Features of Human Ear Ossicles
Authors: Mudhol R. S. , Narahari Sindhu , Havaldar RajeshRadhakrishna 
Published: July 2022

Introduction:
The ossicular chain formed by malleus, incus, and stapes, is considered an essential content of the middle ear and is responsible for the transmission of sound vibrations from the tympanic membrane to the oval window. This study aims to evaluate the morphology and anthropometry of ossicles from human cadavers.

Material and Methods:
This is a cross-sectional study conducted in the Department of Otorhinolaryngology and Head-and-Neck Surgery of KAHER's JN Medical College, Belagavi, for 1 year. Twenty fresh cadavers (40 sets of ossicles) were dissected using zero-degree endoscope. With gentle manipulation, ossicles were removed to study anthropometry and morphology of each middle ear bone using osseous sizer.

Results:
Among the three bones, based on mean measurements, the heaviest bone was incus (19.08 mg), followed by malleus (16.65 mg) and the lightest bone was stapes (2.28 mg). The longest bone among the three bones was malleus (7.18 mm), followed by incus (5.71 mm) and stapes (2.70 mm). Malleus showed variations in the distal ends, incus showed variation in the lenticular process and the obturator foramen of stapes had different shapes.

Discussion and Conclusion:
With a rapid rise in the demand for ossiculoplasty in India, knowledge of morphology and possible anthropometric variation existing in Indian subjects is needed to add up to a better understanding of middle ear dynamics.
Estimation of the inflammatory burden and its impact after treatment in periodontally affected pre- and postmenopausal women
Authors: Prasanna Jammula Surya , Chinta Sumadhura 
Published: July 2022

Context:
Menopause, when menstruation ceases, is seen with an overall increase in body response to inflammation. Gingiva is no such exception. Gingival inflammation which leads to periodontitis is a condition, which is severe inflammatory in nature, affecting the tissues surrounding the teeth. If not treated in time apparently tooth loss might take place. Pre- and postmenopausal conditions, more or less are critical for inflammatory changes.

Aims:
In this study, among both conditions which one was oppressive and which reciprocated more to scaling was examined.

Settings and Design:
This study was a cross-sectional interventional study.

Materials and Methods:
Sixty female subjects aged between 40 and 50 years with periodontitis were recruited. These were meticulously examined by a gynecologist and equated into two groups of 30 patients each, Group I – premenopausal and Group II – postmenopausal women. Plaque index, periodontal index (PDI), and sulcular bleeding index were compared at baseline and 3 months after scaling.

Statistical Analysis Used:
IBM Statistical Package for the Social Sciences (SPSS) version 21 software was used. An independent sample t-test was applied for percentage decrement and intergroup comparison and paired t-test for intergroup comparisons.

Results:
Reduction was significant in all the above parameters in both the groups noted on intragroup comparison from baseline to 3 months (P < 0.001). However, the intergroup showed no significance except PDI at baseline.

Conclusions:
There was a remarkable effect of scaling on inflammatory conditions such as menopause and periodontitis. In the premenopausal stage only, if women undergo periodontal therapy, it can prevent future aggressive inflammatory changes in the postmenopausal stage.
Role of scan body material and shape on the accuracy of complete arch implant digitalization
Authors: Karthhik Raadhikka , Raj Bharath , Karthikeyan B. V. 
Published: July 2022

Purpose:
The aim of the study was to evaluate how the intraoral scan body (SB) material and shape affects the scanning accuracy and scan time in completely edentulous situations since it is not well understood.

Methodology:
Two SB systems were evaluated: SB-1 group (Polyetheretherketone (PEEK)/Flag shaped, Biohorizon, USA), and SB-2 group (Titanium/cylindrical shape, Bioline, GmbH). On completely edentulous mandibular model with 4 dental implants (TMR 4.6, Biohorizon, USA) with scan bodies were positioned in the first molar and canine. The model was scanned using a calibrated laboratory scanner (D2000; 3Shape) to generate a master reference model (MRM). Ten consecutive digital impressions Standard Tessellation Language file were made of the model using an intraoral scanner (Trios, 3Shape A/S) for both the test groups. The test scans were superimposed over the MRM using a best-fit algorithm, and then, the distance deviation and angular deviation of the scan bodies were calculated. Scan time was also recorded. Mann–Whitney U-test was used to statistical analysis. P > 0.05 considered statistically significant.

Results:
Statistically significant differences were found between the SB material and shape on the linear measurement, angular deviation, and scan time (P < 0.05). The SB-1 group achieved higher accuracy overall and also exhibited noticeably lower scan time.

Conclusion:
The quality of digital intraoral impressions seems to be influenced by both the geometry and material of the SB. For clinical practice, the PEEK material seems clinically beneficial for decision-making.
Effect of Formaldehyde Exposure on Some Cardiovascular Indices among Morticians in Benin City Nigeria
Authors: Ebojele Frederick Oseyomon , Iyawe Vincent Imagbovomwan 
Published: July 2022

Introduction:
The effect of formaldehyde exposure on some indices of cardiovascular function among morticians in Benin City was studied.

Materials and Methods:
Fifty subjects were recruited for the study which included 10 nonmorticians and 40 morticians. Subjects were divided into five groups A, B, C, D, and E according to their duration (in years) of exposure to formaldehyde with ten subjects in each group. Group A served as the control (nonmorticians), whereas Groups B, C, D, and E served as the test groups with 0–5 years, 6–10 years, 11–20 years, and >20 years exposures, respectively. Anthropometric parameters were measured as well as some cardiovascular indices which include pulse rate, systolic blood pressure (SBP), diastolic blood pressure (DBP), pulse pressure, and mean arterial pressure (MAP). Statistical analysis was done using GraphPad Prism version 5.0. Results were presented as mean ± standard error of the mean analysis of variance was used to compare the means of test and control values, whereas post hoc test was done using Student[FIGURE DASH]Newman[FIGURE DASH]Keuls test and a P < 0.05 was considered as statistically significant.

Results:
Results showed significant increases in SBP, DBP, and MAP among Group E morticians.

Conclusion:
It was therefore concluded that prolonged exposure to formaldehyde could affect the cardiovascular health of morticians.