bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluating the reliability, validity, and utility of overlapping networks: Implications for network theories of cognition
Authors: Cookson Savannah L. , D'Esposito Mark 
Published: November 2022

AbstractBrain network definitions typically assume nonoverlap or minimal overlap, ignoring regions' connections to multiple networks. However, new methods are emerging that emphasize network overlap. Here, we investigated the reliability and validity of one assignment method, the mixed membership algorithm, and explored its potential utility for identifying gaps in existing network models of cognition. We first assessed between‐sample reliability of overlapping assignments with a split‐half design; a bootstrapped Dice similarity analysis demonstrated good agreement between the networks from the two subgroups. Next, we assessed whether overlapping networks captured expected nonoverlapping topographies; overlapping networks captured portions of one to three nonoverlapping topographies, which aligned with canonical network definitions. Following this, a relative entropy analysis showed that a majority of regions participated in more than one network, as is seen biologically, and many regions did not show preferential connection to any one network. Finally, we explored overlapping network membership in regions of the dual‐networks model of cognitive control, showing that almost every region was a member of multiple networks. Thus, the mixed membership algorithm produces consistent and biologically plausible networks, which presumably will allow for the development of more complete network models of cognition.
A case of pseudoprogression in avelumab maintenance therapy for metastatic bladder cancer
Authors: Hayakawa Nozomi , Kikuchi Eiji 
Published: November 2022

IntroductionA unique phenomenon of immune therapy is pseudoprogression; however, a definite mechanism and predictive factors remain unclear. We herein report a case of pseudoprogression with avelumab maintenance therapy.Case presentationA 67‐year‐old male diagnosed with muscle‐invasive bladder cancer with lung metastasis was treated with four cycles of gemcitabine and cisplatin chemotherapy immediately after cystectomy and ileal conduit urinary diversion. The response to cisplatin‐based chemotherapy was a stable disease. Avelumab maintenance therapy was started after first‐line chemotherapy but was interrupted due to his general fatigue after the third administration of avelumab. At that time, computed tomography (CT) revealed an increased size of lung metastases. Two months after the interruption, avelumab maintenance therapy was restarted. At the end of the seventh dose of avelumab administration, CT showed a dramatic reduction of lung metastatic tumors.ConclusionPseudoprogression may also occur with avelumab maintenance therapy in metastatic bladder cancer.
Time‐course analysis of pulmonary inflammation induced by intratracheal instillation of nanosized crystalline silica particles in F344 rats
Authors: Kobayashi Toshio , Tsubokura Yasuhiro , Oshima Yutaka , Sasaki Takeshi , Kawaguchi Kenji , Koga Kenji , Uchida Kunio , Shinohara Naohide , Ajimi Shozo , Kayashima Takakazu , Nakai Makoto , Imatanaka Nobuya 
Published: November 2022

AbstractCrystalline silica is an important cause of serious pulmonary diseases, and its toxic potential is known to be associated with its surface electrical properties. However, in vivo data clarifying the relevance of silica's toxic potential, especially its long‐term effects, remain insufficient. To investigate the contribution of physico‐chemical property including surface potential on the hazard of nanocrystalline silica, we performed single intratracheal instillation testing using five different crystalline silicas in a rat model and assessed time‐course changes in pulmonary inflammation, lung burden, and thoracic lymph node loads. Silica‐nanoparticles were prepared from two commercial products (Min‐U‐Sil5 [MS5] and SIO07PB [SPB]) using three different pretreatments: centrifugation (C), grinding (G), and surface dissolving (D). The five types of silica particles—MS5, MS5_C, SPB_C, SPB_G, and SPB_D—were intratracheally instilled into male F344 rats at doses of 0 mg/kg (purified water), 0.22 mg/kg (SPB), and 0.67, 2, or 6 mg/kg (MS5). Bronchoalveolar lavage, a lung burden analysis, and histopathological examination were performed at 3, 28, and 91 days after instillation. Granuloma formation was present in MS5 group at 91 days after instillation, although granuloma formation was suppressed in MS5_C group, which had a smaller particle size. SPB_C induced severe and progressive inflammation and kinetic lung overload, whereas SPB_G and SPB_D induced only slight and transient acute inflammation. Our results support that in vivo toxic potential of nanosilica by intratracheal instillation may involve with surface electrical properties leading to prolonged effect and may not be dependent not only on surface properties but also on other physico‐chemical properties.
The voluntary sustainability standards and their contribution towards the achievement of the Sustainable Development Goals: A systematic review on the coffee sector
Authors: Rubio‐Jovel Karla 
Published: November 2022

AbstractIn 2015, the United Nations adopted the Sustainable Development Goals (SDGs). Voluntary sustainability standards (VSSs) precede the SDGs and are a major governance tool for sustainability. Consequently, it is important to understand the role of VSS towards the achievement of the SDGs. This article contributes to answer this question through a systematic review of literature. Results revealed research gaps for key SDGs, such as SDG 5 (Gender Equality) and SDG 10 (Reduced Inequalities). Another relevant finding is that more than half of the studied variables showed no significant difference between intervention or control group, or no significant change over time. This article encourages VSSs and policymakers to work collaboratively towards the use of common indicators and increased data transparency.
既往のない妊娠初期の妊婦が水中毒による意識障害を呈した1例(Impaired consciousness caused by water intoxication in a previously healthy woman in the first trimester of pregnancy: a case report)
Authors: 功祐 三宅 , 成人 石川 , 恒平 蓑田 , 彩華 眞田 , 学 成澤 , 俊一 二瓶 , 俊彦 真弓 
Published: November 2022

要旨水中毒は精神科疾患に合併することが多い。今回，精神疾患などの既往がなく，妊娠初期に水中毒を発症した稀な症例を経験したため報告する。症例は31歳の妊娠6週・初産婦。来院日の1週間前から嘔気，気分不良，食思不振を認め，近医産婦人科でつわりと診断された。その後も食事の匂いを嗅ぐだけで気分が悪くなり，来院4日前からは毎日水のみを5L程度摂取していた。来院日まで著変はなかったが，突然倒れ，呼びかけに反応しなくなり当院救急搬送された。来院時，意識レベルはGlasgow coma scale（GCS）E1V1M3，明らかな神経学的所見は認めなかった。頭部CTで異常所見を認めず，血清Na値 112mmol/L，血清浸透圧 250mOsm/kg/H2O，尿中Na値 8mmol/Lと低値であったため，水中毒による低Na血症と診断し，輸液管理・電解質補正を行った。第4病日に血清Na 130mmol/Lまで軽快し意識清明となり，第8病日に自宅退院となった。妊娠40週4日目に経膣分娩で出産し，母児ともに問題なく経過した。本症例ではとくに既往のない妊娠初期の妊婦がつわりのため，水のみを多量に摂取し，水中毒を発症し意識障害を呈したと推察される。食事摂取不良の妊娠初期の意識障害症例では早期から電解質異常を鑑別することが重要である。
Individual local human thermal climates in the Hungarian lowland: Estimations by a simple clothing resistance‐operative temperature model
Authors: Ács Ferenc , Kristóf Erzsébet , Zsákai Annamária 
Published: November 2022

AbstractHuman thermal climate in the Hungarian lowland is investigated by using a clothing resistance‐operative temperature model performing individual, local, and long‐term concurrent observations of weather and human thermal perception. Human thermal load is characterized in terms of clothing resistance rcl and operative temperature To. The model is also used as a tool to analyse the relationship between rcl and the structural parameters of the body (relative fat mass index (fatBMI) and relative muscle mass index (muscleBMI)). This analysis works with data collected on more than 1,000 occasions of weather and thermal perception observation and uses body structure data of more than 3,000 adults and children. By analysing the data, the following human thermal climate characteristics have been established. (a) To of about 80°C can be considered as the upper limit of heat stress in the Hungarian lowland, similarly, To of about −35 to −37°C can be taken as the lower limit of cold stress. (b) Interpersonal thermal load variations increase with increasing of cold stress; these variations are the smallest within the “thermoneutral” zone. (c) In cold stress situations, there is a significant sexual dimorphism in the relationship between rcl and fatBMI. (d) In night time period of the day, To can vary between 25°C and the lower limit of cold stress. In this range of To, thermal perception types “neutral,” “cool,” “cold,” and “very cold” occurred. Based on the results, it can be seen that interpersonal thermal load variations cannot be neglected in extreme cold weather conditions, and that interpersonal variations of fatBMI index are determinant in the formation of individual clothing resistance.
Divergent and Convergent Thinking across the Schoolyears: A Dynamic Perspective on Creativity Development
Authors: Eon Duval Philippe , Frick Aurélien , Denervaud Solange 
Published: November 2022

ABSTRACTCreative thinking is critical to overcome many daily life situations. As such, there has been a growing interest on how creative thinking develops during childhood. However, little is known about the underlying mechanisms driving its development. Indeed, almost all research has focused on divergent thinking, leaving aside convergent thinking, and did not thoroughly investigate how internal and/or external factors influence their development. Here, 222 children aged from 4 to 12 years old attending either a Montessori or a traditional school performed drawing‐based convergent and divergent standardized tasks. In addition, a subset of 41 children were tested using similar tasks for a second session 3 years apart. The results revealed dynamic developmental stages of convergent and divergent thinking. More specifically, a loss of divergent thinking was counterbalanced by a gain of convergent thinking, especially during the fourth‐grade slump (8–10 years old). Although Montessori‐schooled children showed overall higher creative abilities than traditionally schooled children, no differences were observed in the developmental trajectories of convergent and divergent thinking between the two pedagogies. This suggests that progress and decrease in creative thinking may be mostly due to internal factors such as brain maturation factors than external factors such as peer pressure.
Kinematic function of knee implant designs across a range of daily activities
Authors: Kour R. Y. Nigel , Guan Shanyuanye , Dowsey Michelle M. , Choong Peter F. , Pandy Marcus G. 
Published: November 2022

AbstractThe aim of this randomized controlled trial was to measure and compare six‐degree‐of‐freedom (6‐DOF) knee joint motion of three total knee arthroplasty (TKA) implant designs across a range of daily activities. Seventy‐five TKA patients were recruited to this study and randomly assigned a posterior‐stabilized (PS), cruciate‐retaining (CR), or medial‐stabilized (MS) implant. Six months after surgery, patients performed five activities of daily living: level walking, step‐up, step‐down, sit‐to‐stand, and stand‐to‐sit. Mobile biplane X‐ray imaging was used to measure 6‐DOF knee kinematics and the center of rotation of the knee in the transverse plane for each activity. Mean 6‐DOF knee kinematics were consistently similar for PS and CR, whereas MS was more externally rotated and abducted, and lateral shift was lower across all activities. Peak‐to‐peak anterior drawer for MS was also significantly lower during walking, step‐up, and step‐down (p < 0.017). The center of rotation of the knee in the transverse plane was located on the medial side for MS, whereas PS and CR rotated about the lateral compartment or close to the tibial origin. The kinematic function of MS was more similar to that of the healthy knee than PS and CR based on reduced paradoxical anterior translation at low flexion angles and a transverse center of rotation located in the medial compartment. Overall, 6‐DOF knee joint motion for PS and CR were similar across all daily activities, whereas that measured for MS was appreciably different. The kinematic patterns observed for MS reflects a highly conforming medial articulation in the MS design.
Errors in the radiographic measurement of pelvic incidence
Authors: Iwasa Makoto , Hamada Hidetoshi , Uemura Keisuke , Ando Wataru , Takao Masaki , Sugano Nobuhiko 
Published: November 2022

AbstractPelvic incidence (PI) is often quantified in patients undergoing total hip arthroplasty. Errors in radiographic PI measurements can affect clinical outcomes. The purposes of this study were (1) to evaluate the error in radiographic PI measurement in patients with hip osteoarthritis (OA) and (2) to analyze the factors related to the error. Radiographs and computer tomography (CT) images of 100 patients (24 men and 76 women; mean age 63.7 years) with unilateral OA were reviewed. The error in radiographic PI measurement was defined as the difference between the radiographic measurement of the PI (rPI) and the accurate value of PI measured using CT images (cPI). Factors related to the error in the rPI were analyzed, including the coronal and axial rotation of the pelvis on lateral radiographs. The degree of coronal and axial rotation was expressed as the angle of rotation around the anteroposterior and craniocaudal axes. The mean rPI was significantly larger than the cPI (57.8° and 54.1°, p < 0.01). The error in the rPI was 3.6° on average and 15.8° at maximum. The mean coronal and axial rotation of the pelvis was 9.6° and 4.4°, respectively. The error in the rPI positively correlated with coronal pelvic rotation and rPI, and negatively correlated with axial pelvic rotation (p < 0.01, r = 0.35, 0.43, and −0.45, respectively). The rPI was 3.6° larger on average than the cPI in patients with hip OA. Coronal and axial rotation of the pelvis and a large PI were related to the error in the rPI.
Lactitol and β‐cyclodextrin alleviate the intensity of goaty flavor
Authors: Ma Yue , Li Jinzhe , Liu Yue , Dou Nianxu , Mu Sinan , Wei Xuan , Bilawal Akhunzada , Hou Juncai , Jiang Zhanmei 
Published: November 2022

AbstractBACKGROUNDGoat milk has balanced nutritional composition, is conducive to digestion and absorption, and does not easily lead to allergic reactions. However, the special goaty flavor in milk has seriously affected consumer acceptance. It is imperative to alleviate the goaty flavor in a safe and efficient way.RESULTSThis study indicated that the supplementation of 6 g kg−1 β‐cyclodextrin or 8 g kg−1 lactitol in goat milk significantly alleviated goaty flavor and improved sensory characteristics. Furthermore, the supplementation of β‐cyclodextrin and lactitol had a synergistic effect in reducing the content of free fatty acids that cause goaty flavor. The content of caproic acid (C6H12O2), octanoic acid (C8H6O2), and decanoic acid (C10H20O2) decreased by 42.46%, 39.45%, and 46.41%, respectively, after a combined group was supplemented with 6 g kg−1 β‐cyclodextrin and 7 g kg−1 lactitol, which was significantly lower than in groups given β‐cyclodextrin or lactitol individually.CONCLUSIONThis study provides a novel and effective approach to alleviate goaty flavor and promote the competitiveness of goat milk products. © 2022 Society of Chemical Industry.
ALBI grade predicts suitability for further systemic therapy following sorafenib in patients with advanced hepatocellular carcinoma
Authors: Fakih Omar , Haddad Suraiya S. , Walker Sophie , Edeline Julien , Estrade Florien , Wang Xin , Lamarca Angela , McNamara Mairéad G. , Valle Juan W. , Hubner Richard A. 
Published: November 2022

AbstractBackground & AimsPreserved performance status (PS) and liver function are required for systemic therapy in patients with advanced hepatocellular carcinoma (aHCC). We investigated the frequency of suitability for further systemic therapies following sorafenib in aHCC.MethodsDemographic, tumour and therapy‐related data were collected retrospectively for patients with aHCC who received sorafenib at a UK tertiary referral centre (training cohort), and an independent French centre (validation cohort). The primary endpoint was percentage of patients with Child‐Pugh class A (CP‐A) liver disease and PS 0–1 after sorafenib discontinuation.ResultsSorafenib was received by 182 patients. After sorafenib discontinuation, 93 patients (51%) were CP‐A and 60 patients (33%) were PS 0–1; 43 patients (24%) were both CP‐A and PS 0–1. On multivariable analysis, patients with Albumin‐Bilirubin (ALBI) score of 1 at time of sorafenib commencement were more likely to be suitable for post‐sorafenib therapy, (44% grade 1 vs 15% grade 2) (OR 3.76, 95%CI 1.72–8.25, P = .0009). In the validation cohort of 216 patients baseline ALBI grade was also significantly associated with suitability for further systemic therapy (P = .008).ConclusionsMost patients with aHCC are not suitable for further systemic therapy after sorafenib, but those with ALBI grade 1 have a greater likelihood of suitability.
Patient injuries from tonsil and adenoid surgery in Finland
Authors: Sjöblom Henrik M. , Timgren Jaakko M. , Piitulainen Jaakko M. , Jero Jussi 
Published: November 2022

AbstractObjectivesThe aims of this national register‐based study were to examine patient injury claims related to tonsil and adenoid surgery injuries and to compare the frequency of claims between tonsillectomies and tonsillotomies in Finland.MethodsWe analyzed the complaints related to tonsil and adenoid surgery received by the Finnish Patient Insurance Center (PIC) between the years 2000 and 2019. One hundred seventy‐two cases were included in the analysis. The annual surgery rates between the years 2000 and 2018 were acquired from the Finnish Institute for Health and Welfare.ResultsDuring the years 2000 to 2018, a total of 292,679 patients had tonsil and/or adenoid surgery nationwide. For tonsil or adenoid surgeries, the national average was 5.3 cases and 1.8 cases per 10,000, respectively, resulting in patient injury claims and compensations. A total of 33.1% of the claims regarding tonsil or adenoid surgery processed by the PIC were compensated. Most of the claims were made after a tonsillectomy (87.8%), and few were made after a tonsillotomy (1.7%). Seven deaths were recorded.ConclusionPatient injuries from tonsil and adenoid surgeries were mostly related to traditional extracapsular tonsillectomies. Most surgeries, along with most complications, involved specialists, who performed routine operations in high‐volume centers. Surgeries for acute or recurrent infections resulted in more claims. Severe complications arising from tonsil and adenoid surgeries were rare.Level of Evidence4.
Exponential decay for semilinear wave equation with localized damping in the hyperbolic space
Authors: Carrião Paulo Cesar , Miyagaki Olímpio Hiroshi , Vicente André 
Published: November 2022

AbstractIn this paper, we study the exponential decay of the energy associated to an initial value problem involving the wave equation on the hyperbolic space . The space is the unit disc of endowed with the Riemannian metric g given by , where and , if and , if . Making an appropriate change, the problem can be seen as a singular problem on the boundary of the open ball endowed with the euclidean metric. The proof is based on the multiplier techniques combined with the use of Hardy's inequality, in a version due to the Brezis–Marcus, which allows us to overcome the difficulty involving the singularities.
Patient pathway in a tertiary referral pelvic floor unit: Telephone triage assessment clinic
Authors: Ferrari Linda , Cuinas Karina , Igbedioh Carlene , Hainsworth Alison , Solanki Deepa , Williams Andrew , Sahai Arun , Kelleher Cornelius , Schizas Alexis 
Published: November 2022

AbstractBackgroundTo meet the increasing demands for colorectal pelvic floor services, a dedicated telephone triage assessment clinic (TTAC) was set up to establish a more efficient pathway, and reduce waiting times and patient's visits to the hospital. The primary aim of this study was to review TTAC in patients suffering from pelvic floor dysfunction and assess its feasibility. Secondary aims include measurement of waiting times for TTAC, main presenting complaints, and main treatment outcomes, including the need for review by a consultant surgeon.MethodsReview of data collected retrospectively in a single tertiary referral center collected from an institutional database.Key resultsBetween January 2016 and October 2017, 1192 patients referred to our pelvic floor unit were suitable for TTAC. Of these, 694 patients had complete records. There were 66 without follow‐up after the initial TTAC, leaving 628 patients for analysis. In all, 86% were females and 14% were males, with a mean age of 52 years (range: 18–89). The median waiting time for TTAC was 31 days (range: 0–184). The main presenting complaint during the TTAC was obstructive defecation in 69.4%, fecal incontinence in 28.5%, and rectal prolapse in 2.1%. In our study, 611 patients had conservative management (97.3%), with a median of three sessions per patient (range: 1–16), while 82 patients (13.1%) needed a surgical intervention. Only 223 patients (35.5%) were reviewed by a consultant at some stage during the study period.Conclusions and InferencesTo optimize resources, an adequate triage system allowed us to streamline the pathway for each individual patient with pelvic floor dysfunction according to their symptoms and/or test results with the aim of reducing waiting times and expediting treatment.
Residential parenting services: An integrative literature review of characteristics, service usage and parent and staff perspectives
Authors: Dahlen Hannah Grace , Ormsby Simone Maree , Brownhill Suzanne , Fowler Cathrine , Schmied Virginia 
Published: November 2022

AbstractAimsThe primary aim of the review was to provide an overall assessment of residential parenting services in Australia, by describing the characteristics of infants and parents using residential parenting services, their prior service use and reasons for admission, referral pathways for access and parenting and infant outcomes. The secondary aims were to explore parent and staff perception of the programmes.DesignAn integrative literature review.MethodsA systematic and comprehensive search of health and social sciences databases was conducted for studies related to residential parenting services (published between 1st January 1990–31st December 2019). Six hundred and eleven peer‐reviewed papers were identified, after which 301 duplicates were removed and an additional 256 papers excluded after titles/abstracts were read. Of the remaining 54 abstracts/papers, a further 14 were omitted as not relevant. Forty papers were independently reviewed by four authors. ENTREQ and MOOSE checklists were applied.ResultsThirty studies were quantitative, nine were qualitative, and one was mixed methods. All studies originated from in Australia. Women and babies admitted to residential parenting services were found more likely to be: older, Australian born, from higher socio‐economic groups, and first‐time mothers, and having labour and birth interventions and a history of mental health disorders. The babies were more likely to be twins, male and admitted with sleep disorders and dysregulated behaviour. Studies reporting postintervention outcomes demonstrated improvements to maternal mental health, breastfeeding, parenting confidence and sleep quality, and infant sleeping and behaviour.