bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of dietary vitamin E supplementation levels on growth performance, breast muscle meat quality characteristics, and fatty acid composition of geese
Authors: Yang Zhi , Xu Chen , Sun Qingyu , Xu Xuean , Yu Jun , Yang Haiming , Wang Zhiyue 
Published: July 2022

AbstractThis study investigated the effects of dietary supplementation with vitamin E (VE) on the growth performance, breast muscle quality, fatty acid (FA) composition, and muscle fiber characteristics of geese. In the present study, a total of 240 healthy 29‐day‐old male Jiangnan white geese were randomly divided into six experimental groups, with five replicates in each group and eight geese in each replicate. Group A, the control group, was fed a basal diet; Groups B, C, D, E, and F were fed diets supplemented with 5, 10, 20, 40, and 80 mg/kg VE. After feeding for 70 days of age, one gosling from each replicate was randomly selected and slaughtered to assess the breast muscle quality characteristics, lipid oxidation, FA composition, and muscle fiber characteristics. The results showed that dietary VE supplementation did not significantly affect the growth performance, breast muscle quality characteristics, or muscle fiber characteristics of geese (p > 0.05). Dietary supplementation with 20, 40, and 80 mg/kg VE significantly decreased the malondialdehyde (MDA) content of the breast muscle compared with the control group (P < 0.05). Dietary supplementation with 40 and 80 mg/kg VE significantly increased the retention of α‐tocopherol in pectoral muscle, decreased polyunsaturated fatty acid (PUFA) oxidation, and increased the proportion of n‐3 PUFAs (p < 0.05). In conclusion, dietary supplementation with 5–80 mg/kg VE to the basal diet (VE content of the basal diet: 17.53 mg/kg) had no significant effect on the growth performance of geese. However, dietary supplementation with 40–80 mg VE increased the retention of α‐tocopherol in breast muscle tissue, reduced the oxidation of PUFAs, and increased the content of n‐3 PUFAs. Thus, under these experimental conditions, dietary supplementation with 40–80 mg/kg VE is recommended, which is beneficial to human health.Practical ApplicationAppropriate supplementation of VE could increase meat quality and the beneficial components in breast muscle of geese. It provides a theoretical basis for future production of high‐quality goose meat.
Structural Variability and Rifting Process of the Segmented Cenozoic Pearl River Mouth Basin, Northern Continental Margin of the South China Sea
Authors: MA Bingshan , QI Jiafu , WU Guanghui , REN Jianye , YANG Linlong , SUN Tong , CHEN Shi , CHEN Weichang , GE Jiawang 
Published: July 2022

AbstractThe Pearl River Mouth Basin (PRMB) is an important area for studying the evolution of continental marginal basins in the northern South China Sea (SCS), but the structural variability and spatiotemporal rifting process remains poorly understood. This study investigates the differential structural features of the eastern, middle and western PRMB, as well as the extensional deformation laws in operation during the rifting stage, according to an integrated analysis of geometric characteristics and kinematic parameters, i.e., horizontal displacement and stretching factors of basin and crust. The PRMB underwent at least three phases of intense extension, which varied in time and space. (1) During the middle Eocene, most sags in the PRMB were intensely stretched and high‐angle planar to listric boundary faults controlled the wedge‐shaped stratigraphic geometry. (2) During the late Eocene‐to‐early Oligocene, the stratigraphic geometry of the sags was slightly wedge‐shaped and continuously controlled by boundary faults, however, the extensional strength decreased relatively in the Northern depression zone, but increased in the Southern depression zone. (3) During the late Oligocene, the extension was extremely weak in the northeast PRMB, but relatively strong in the southwest PRMB, leading to tabular stratigraphic geometry in the northeast PRMB, but localized slightly wedge‐shaped stratigraphic geometry in the southwest. The southwest PRMB still underwent relatively strong extension during the early Miocene. The southwest PRMB that was induced by a small‐scale localized mantle convection system constantly rifted during the late Oligocene, controlled by the weak lithosphere, westward (southwestward) diachronous opening and southward jump of the ocean ridge. The applied quantitative parameters and spatiotemporal rifting process may be used as a reference with which to study the segmented continental margin rifts.
Accretion Processes of Oceanic Crust in Slow‐spreading Ridges: Plagiogranite Perspective of the Xigaze Ophiolite, South Tibet
Authors: LI Yuan , LI Ruibao , YANG Shengbiao , ZHANG Jian , YANG Jingsui 
Published: July 2022

AbstractStructural and petrological data suggest that the Xigaze ophiolite from the Yarlung Zangbo Suture Zone (YZSZ) in south Tibet was a typical slow‐spreading ridge. A new field, geochemical, mineral, and U‐Pb zircon dataset of plagiogranite intrusions were used to constrain the dynamic processes of oceanic accretion in this slow‐spreading ridge. Plagiogranites mainly occur as dykes or intrusions intruded into the whole sequence of the ophiolite and have a similar orientation to the dolerite dykes developed in the late stage of detachment faulting. U‐Pb zircon ages of 122–123 Ma were obtained for two types of plagiogranites and associated dolerite dykes. Detailed geochemical and mineralogical examinations suggest that the plagiogranites are the product of low‐pressure (2–3 kbar) fractional crystallization of mid‐ocean ridge basalt‐like magma and unlikely to have been derived from the partial melting of hydrous gabbroic rocks. The complex cross‐cut relationship between the plagiogranites and ophiolite sequence reflects that they are controlled by small discontinued melt lenses rather than a big magma chamber under the ridge axis and reveals multiple injections during the oceanic crust accretion. The formation of plagiogranites possibly reflects the complex characteristic of oceanic accretion at slow‐spreading ridges, time‐dependent on structural (external) and magmatic (internal) processes.
Prevalence, co‐morbidities, and in‐hospital mortality of patients hospitalized with alcohol‐associated hepatitis in the United States from 2015 to 2019
Authors: Marlowe Natalie , Lam David , Krebs William , Lin WeiQi , Liangpunsakul Suthat 
Published: July 2022

AbstractBackgroundThe goals of our study are to determine the most recent trends in hospitalization, mortality, and healthcare utilization among hospitalized patients with alcohol‐associated hepatitis (AH) in the United States.MethodsWe examined the recent prevalence, co‐morbidities, and mortality in hospitalized AH patients in the United States based on the available National Inpatient Sample (NIS) data (2015 to 2019) using appropriate International Classification of Diseases (ICD) codes. We reported our data as national estimates based on the discharge weighting variable (DISCWT). Logistic regression analyses were used to determine factors associated with mortality.ResultsWe observed an increase in the total number of hospitalized AH patients from 110,135 in 2015 to 136,620 in 2019, which represented 386 per 100,000 total hospitalizations or 42 per 100,000 US population, which in 2019 was 328 million. Patients were a mean of 48 years old and the majority were White and male. The average length of stay was around 6 days with an overall in‐hospital mortality that decreased from 4.19% in 2015 to 3.86% in 2019 (p‐value for trend = <0.0001). During the 5‐year study period, a total of 24,795 hospitalized AH patients died and 592,885 survived the hospital stay. Those who died were older, had a longer length of stay, and higher hospital charges during the stay. Mortality was significantly greater in patients who presented with complications from portal hypertension, those with acute renal failure, underlying cirrhosis, and sepsis.ConclusionsOur study documented the increasing prevalence of hospitalized AH patients and their significant associated healthcare costs and utilization. Our results underscore a continuing unmet and urgent need to identify effective therapies for hospitalized AH patients.
Qualitative and quantitative analysis of doctor–patient interactions during andrological consultations
Authors: Santi Daniele , Spaggiari Giorgia , Romeo Marilina , Ebert Riccardo , Corradini Federico , Baraldi Claudio , Granata Antonio R. M. , Rochira Vincenzo , Simoni Manuela , Gavioli Laura , Niemants Natacha S. A. 
Published: July 2022

AbstractIntroductionAlthough a trustworthy connection between doctor and patient is crucial in clinical practice, it could be hindered by different cultural and linguistic backgrounds. Moreover, an effective doctor–patient interaction could be even more challenging in andrological fields, in which psychological and social components are predominant.AimTo analyse the doctor–patient relationship in the andrological field, applying both qualitative and quantitative analyses.Methodsmonocentric, cross‐sectional, observational study was performed between May and December 2018. During the study, all patients aged >18 years attending the Modena Andrology Unit for couple infertility or erectile dysfunction were enrolled and the doctor–patients interaction recorded. Patients were divided into two groups depending on their medical seeking and were further divided between native and non‐native speakers of Italian. All patients underwent a routine andrological examination. Every first medical consultation was audio‐recorded and transcribed using “ELAN” software for socio‐linguistic analysis. Transcriptions underwent qualitative analysis through conversation analysis. Then, quantitative analyses were performed, and interaction parameters underwent correlation analyses.ResultsTwenty‐five patients were enrolled. The analysis of the andrological interview allowed to recognise five consecutive phases, following a semi‐standardized pattern. Patients without linguistic barriers and with infertility problems showed more autonomous contribution during the consultation. No difference arose in the sexual dysfunctions group. Doctor's explanations were frequent, but when linguistic barrier was present or Italian patients seemed less talkative, explanations were shorter, and doctors tried to use other conversational mechanisms to promote understanding. Patient's variables were significantly lower compared to the doctor, considering the number of turns (p = 0.025) and their minimum (p = 0.032), maximum (p < 0.001), and average durations (p < 0.001). Only patient's latency was significantly higher than the doctor's (p = 0.001).ConclusionThis is the first attempt to analyse the doctor–patient relationship in andrology using authentic audio‐recorded consultations. The results confirmed that a patient‐centred communication must be applied also in andrological consultations. However, the topics discussed may require more “medical formulation” to be acceptable to the participants in this context.
Implementation of a clinical pathway for osteoporosis management within an Orthopaedic Fracture Clinic
Authors: Narula Siddarth , Kelly David , Welthy Lisa , Prosser Gareth , Mattin Andrew , Yates Piers Jason , Seymour Hannah 
Published: July 2022

AbstractBackgroundA fracture liaison service (FLS) is a multidisciplinary system approach to reducing subsequent fracture risk in patients with a recent fragility fracture. This study investigated the utility of an alternate model delivered by orthopaedic surgeons in increasing the investigation and treatment of osteoporosis within an orthopaedic fracture clinic in a tertiary hospital.MethodWe established a pathway of treatment (FLS) for women ≥50 years old with a minimal trauma fracture (MTF) in the orthopaedic fracture clinic using existing clinic resources to identify patients. All female patients ≥50 years old with upper limb MTFs during the study period were included and compared with historical controls prior to the intervention. The intervention and control groups were compared to assess the capacity of the new model of care to identify suitable patients and deliver best practice care.ResultsAfter the intervention the cumulative rate of osteoporosis screening increased from 52/173 to 201/318 (P < 0.001). Among the patients who were screened for osteoporosis the treatment rate increased from 25/52 to 126/201 (P < 0.001). The intervention resulted in a significant reduction in patients who were not screened after MTF from 87/173 to 40/318 (P < 0.001).ConclusionWe have developed a low‐cost pathway developed by the orthogeriatric team integrated into an orthopaedic fracture clinic that leads to increased screening and treatment of osteoporosis. This model was implemented in a tertiary hospital with an integrated inpatient orthogeriatric service and highly engaged orthopaedic surgeons and may not be applicable in other settings.
Indications for intensive care unit treatment among neonates born to mothers with thyroid disease: A population‐based cohort study
Authors: Turunen Suvi , Vääräsmäki Marja , Marttila Riitta , Leinonen Maarit K. , Gissler Mika , Männistö Tuija , Suvanto Eila 
Published: July 2022

AbstractIntroductionThyroid diseases in pregnancy are relatively common and are associated with adverse pregnancy and perinatal outcomes, increasing a neonate’s risk of admission to the neonatal intensive care unit (NICU). The aim of this study was to evaluate the indications for increased risk of NICU admission among the neonates of hypothyroid and hyperthyroid mothers.Material and methodsThe study data consisted of all singleton deliveries (n = 734 773) between 2004 and 2016 in Finland collected from the Finnish Medical Birth Register. The odds of NICU admission (with 95% confidence intervals) were compared between the neonates of hypothyroid or hyperthyroid mothers and of mothers without any thyroid diseases by specified neonatal characteristics and morbidities using logistic regression analysis. The studied neonatal characteristics were preterm birth (<37+0 gestational weeks), low birthweight (<2500 g), the rate of small‐ and large‐for‐gestational age infants, and eight disease‐specific neonatal outcomes: asphyxia, respiratory distress syndrome, meconium aspiration syndrome, pneumothorax, cardiovascular problems, infections, jaundice and hypoglycemia.ResultsThe most common indications for NICU care were principally the same in the neonates of the mothers with and without thyroid disease: respiratory distress syndrome, infections, preterm birth, low birthweight and neonatal hypoglycemia. The preterm neonates, neonates with low birthweight, and large‐for‐gestational‐age infants had increased odds of NICU admission if their mother had hypothyroidism. Also neonates with cardiovascular problems, jaundice or hypoglycemia associated with maternal diabetes had increased odds of NICU admissions if their mother had hypothyroidism. Further, the preterm neonates, large‐for‐gestational‐age infants, and term infants with jaundice had increased odds of NICU admission if their mother had hyperthyroidism.ConclusionsThe most common indications for NICU care were similar for the neonates of the mothers with and without thyroid disease. However, the neonates of the mothers with thyroid diseases were more likely to need NICU care. The neonates of the mothers with thyroid diseases had higher odds of NICU treatment in cases of preterm birth, large for gestational age, and hypoglycemia.
Association of platelet deficiency with severe retinopathy of prematurity: a review
Authors: Seliniotaki Aikaterini K. , Haidich Anna‐Bettina , Moutzouri Stella , Lithoxopoulou Maria , Ziakas Nikolaos , Lundgren Pia , Hellström Ann , Mataftsi Asimina 
Published: July 2022

AbstractAimThe aim of this review was to compile existing evidence on the role of platelets in the development of severe retinopathy of prematurity (ROP), highlight the strengths and weaknesses of the available studies and critically discuss the reported data.MethodsA comprehensive literature search was conducted on PubMed from January 2000 to January 2022, and the reference lists of the included studies were screened manually.ResultsThere were 19 primary studies that fulfilled the eligibility criteria. Experimental research indicated lower platelet count in mice oxygen‐induced retinopathy model compared with normoxia controls, while platelet transfusions suppressed neovascularisation. The latter finding was not consistently confirmed in clinical research, where a low platelet count, an increased number of thrombopenic episodes and of platelet transfusions have all been implicated in the development of ROP requiring treatment, either type I or aggressive posterior or both. However, existing studies exhibit significant clinical heterogeneity and present methodological limitations that imperil their reliability and validity.ConclusionPlatelet deficiency has been associated with severe ROP. However, critical thresholds of platelet parameters are still unrecognised. Future research is required to determine whether platelet parameters can be predictive biomarkers for ROP requiring treatment and at what thresholds.
Greater negative affect reduction expectancies moderate the interactive relationship between emotion regulation difficulties and distress tolerance in predicting loss‐of‐control eating
Authors: Burr Emily K. , Dvorak Robert D. , Peterson Roselyn , De Leon Ardhys N. 
Published: July 2022

AbstractObjectivesLoss‐of‐control eating (LOCE) is often conceptualized as a negative reinforcement mechanism. However, LOCE does not consistently reduce negative affect (NA). One explanation for continued LOCE, despite a lack of NA reduction, may be expectations of NA reduction. Emotion regulation difficulties and low distress tolerance often predict LOCE, but have not been examined in the context of NA reduction expectancies.DesignThis study examined the main and interactive relationships between emotion regulation difficulties, distress tolerance and NA reduction expectancies on LOCE in US adults (n = 3331).MethodThis study consisted of a battery of surveys administered to a national sample of US adults.ResultsResults indicate NA reduction expectancies are robust, eclipsing the predictive effects of other emotion regulation variables. Distress tolerance was only able to attenuate the relationship between emotion regulation difficulties and LOCE when NA reduction expectancies were low.ConclusionsThese findings identify NA reduction expectancies as having a strong relationship with LOCE, such that the protective factor of distress tolerance is only relevant when such expectancies are low. Clinical implications suggest that targeting NA reduction expectancies in eating interventions that bolster emotion regulation difficulties and distress tolerance may improve the effectiveness of said interventions. Additionally, stand‐alone expectancy interventions should be assessed for the purpose of LOCE reduction. Directions for future research are discussed.
Subtyping primary aldosteronism by inconclusive adrenal vein sampling: A derivation and validation study in a tertiary centre
Authors: Zibar Tomsic Karin , Dusek Tina , Alduk Anamarija , Knezevic Nikola , Molnar Vilim , Kraljevic Ivana , Skoric Polovina Tanja , Balasko Annemarie , Solak Mirsala , Matas Nino , Popovac Hrvoje , Kralik‐Oguic Sasa , Kastelan Darko 
Published: July 2022

AbstractObjectiveIndices based on aldosterone/cortisol (A/C) concentration in the successfully cannulated adrenal vein (AV) and in the inferior vena cava (IVC) (AV/IVC) appear to be possible markers to verify the subtype of primary aldosteronism (PA) in the case of inconclusive results of adrenal vein sampling (AVS). The variability of results in previous studies encouraged us to calculate AV/IVC and adrenal A/C cutoff values that could predict the aetiology of PA.MethodsThis retrospective study included 96 patients who underwent AVS due to PA between 2015 and 2020. The derivation cohort ultimately consisted of 60 patients with bilaterally successful AVS and a clear diagnosis of unilateral or bilateral disease. Receiver operating characteristic analysis was used to find the optimal A/C and AV/IVC cutoff values predicting the subtype of PA. The validation cohort consisted of 11 patients with either unsuccessful cannulation or a borderline lateralization index (LI), those patients underwent adrenalectomy because their indices were suggestive of unilateral disease based on the derivation cohort data.ResultsThe cutoff values of A/C ≤ 0.63 or AV/IVC ≤ 0.37 identified unaffected glands with a sensitivity of 91.2% and 97.1%, respectively, and a specificity of 90.7% and 88.4%, respectively. Unilateral ipsilateral gland involvement was characterized by A/C ≥ 3.5 or AV/IVC ≥ 3.4 with a corresponding specificity of 100%. All patients in the validation cohort achieved biochemical remission postoperatively.ConclusionsA/C and AV/IVC cutoff values could be a useful tool to determine the subtype of PA in patients with unilateral successful AVS as well as in patients with a borderline LI.
New insights into the phylogeny of the complex thalloid liverworts (Marchantiopsida) based on chloroplast genomes
Authors: Xiang You‐Liang , Jin Xin‐Jie , Shen Chao , Cheng Xia‐Fang , Shu Lei , Zhu Rui‐Liang 
Published: July 2022

AbstractMarchantiopsida (complex thalloid liverworts) are one of the earliest lineages of embryophytes (land plants), and well‐known for their air pores and chambers, pegged rhizoids, and absence of organellular RNA editing sites. Despite their importance to an understanding of early embryophyte evolution, many key nodes within this class remain poorly resolved, owing to the paucity of genetic loci previously available for phylogenetic analyses. Here, we sequenced 54 plastomes, representing 28 genera, nearly all families, and all orders of Marchantiopsida. Based on these plastomes, we present a hypothesis of deep relationships within the class, and make the first investigations of gene contents and synteny. Overall, the Marchantiopsida plastomes were well‐conserved, with the exception of the genus Cyathodium that has plastomes with higher GC content, fewer single sequence repeats (SSRs), and more structural variations, implying that this genus might possess RNA editing sites. Abundant repetitive elements and six highly divergent regions were identified as suitable for future infrafamilial taxonomic studies. The phylogenetic topology of Sphaerocarpales, Neohodgsoniales and Blasiales within Marchantiopsida was essentially congruent with previous studies but generally we obtained higher support values. Based on molecular evidence and previous morphological studies, we include Lunulariales in Marchantiales and suggest the retention of narrowed delimitation of monotypic families. The phylogenetic relationships within Marchantiales were better resolved, and 13 monophyletic families were recovered. Our analyses confirmed that the loss of intron 2 of ycf3 is a synapomorphy of Marchantiidae. Finally, we propose a new genus, Asterellopsis (Aytoniaceae), and present an updated classification of Marchantiopsida. The highly supported phylogenetic backbone provided here establishes a framework for future comparative and evolutionary studies of the complex thalloid liverworts.