bluuebunny/crossref_metadata_2025_split huggingface dataset:
Modified reverse shock index predicts early outcomes of heart failure with reduced ejection fraction
Authors: Oh Gyu Chul , An Seokyung , Lee Hae‐Young , Cho Hyun‐Jai , Jeon Eun‐Seok , Lee Sang Eun , Kim Jae‐Joong , Kang Seok‐Min , Hwang Kyung‐Kuk , Cho Myeong‐Chan , Chae Shung Chull , Choi Dong‐Ju , Yoo Byung‐Su , Kim Kye Hun , Park Sue K. , Baek Sang Hong 
Published: July 2022

AbstractAimsIncreased blood pressure (BP) and decreased heart rate (HR) are signs of stabilization in patients admitted for acute HF. Changes in BP and HR during admission and their correlation with outcomes were assessed in hospitalized patients with heart failure (HF) with reduced ejection fraction (HFrEF).MethodsA novel modified reverse shock index (mRSI), defined as the ratio between changes in systolic BP and HR during admission, was devised, and its prognostic value in the early outcomes of acute HF was assessed using the Korean Acute HF registry.ResultsAmong 2697 patients with HFrEF (mean age 65.8 ± 14.9 years, 60.6% males), patients with mRSI ≥1.25 at discharge were significantly younger and were more likely to have de novo HF. An mRSI ≥1.25 was associated with a significantly lower incidence of 60‐day and 180‐day all‐cause mortality [hazard ratio (HR) 0.49, 95% confidence interval (CI) 0.31–0.77; HR 0.62, 95% CI 0.45–0.85, respectively], compared with 1 ≤ mRSI < 1.25 (all P < 0.001). Conversely, an mRSI <0.75 was associated with a significantly higher incidence of 60‐day and 180‐day all‐cause mortality (adjusted HR 2.08, 95% CI 1.19–3.62; HR 2.24, 95% CI 1.53–3.27; all P < 0.001). The benefit associated with mRSI ≥1.25 was consistent in sub‐group analyses. The correlation of mRSI and outcomes were also consistent regardless of admission SBP, presence of atrial fibrillation, or use of beta blockers at discharge.ConclusionsIn patients hospitalized for HFrEF, the mRSI was a significant predictor of early outcomes. The mRSI could be used as a tool to assess patient status and guide physicians in treating patients with HFrEF.
Modified Julia Olefination on Pyrrolidinone: Application to the Total Synthesis of Indolizidine 209D
Authors: Raison Bastien , Dussart Nicolas , Gueyrard David 
Published: July 2022

AbstractWe report the olefination of Boc‐ protected pyrrolidinone through a modified Julia olefination. Boc‐protected exo‐enamides can then be easily converted into spirobicyclic structure or can be used as useful intermediate for the preparation of natural indolizidine 209D. This application demonstrates the synthetic potential of our methodology for the synthesis of bicyclic alkaloids.
Influence of viscoelectric effect on diffusioosmotic transport in nanochannel
Authors: Mehta Sumit Kumar , Mondal Pranab Kumar 
Published: July 2022

AbstractWe have investigated the role of viscoelectric effect on diffusioosmotic flow (DOF) through a nanochannel connected with two reservoirs. The transport equations governing the flow dynamics are solved numerically using the finite element technique. We have extensively analyzed the variation of induced field due to electric double layer (EDL) phenomenon, relative viscosity as modulated by the viscoelectric effect as well as reservoir's concentration difference, and their eventual impact on the underlying flow characteristics. It is revealed that the induced electric field in the EDL enhances fluid viscosity substantially near the charged wall at a higher concentration. We have shown that neglecting viscoelectric effect in the paradigm of diffusioosmotic transport overestimates the net throughput, particularly at a higher concentration difference. Furthermore, we show that pertaining to chemiosmosis dominated regime, the average flow velocity modifies with the increase in concentration difference up to a critical value. In comparison, the rise in the strength of resistive electroosmotic actuation by the accumulation of anions in the upstream reservoir reduces the average flow velocity at a higher concentration difference. We have reported a reduction in critical concentration with the increase in viscoelectric effect. The inferences of this analysis are deemed pertinent to reveal the bearing of viscoelectric effect as a flow control mechanism pertaining to DOF at nanoscale.
Selective neural coding of object, feature, and geometry spatial cues in humans
Authors: Ramanoël Stephen , Durteste Marion , Bizeul Alice , Ozier‐Lafontaine Anthony , Bécu Marcia , Sahel José‐Alain , Habas Christophe , Arleo Angelo 
Published: July 2022

AbstractOrienting in space requires the processing of visual spatial cues. The dominant hypothesis about the brain structures mediating the coding of spatial cues stipulates the existence of a hippocampal‐dependent system for the representation of geometry and a striatal‐dependent system for the representation of landmarks. However, this dual‐system hypothesis is based on paradigms that presented spatial cues conveying either conflicting or ambiguous spatial information and that used the term landmark to refer to both discrete three‐dimensional objects and wall features. Here, we test the hypothesis of complex activation patterns in the hippocampus and the striatum during visual coding. We also postulate that object‐based and feature‐based navigation are not equivalent instances of landmark‐based navigation. We examined how the neural networks associated with geometry‐, object‐, and feature‐based spatial navigation compared with a control condition in a two‐choice behavioral paradigm using fMRI. We showed that the hippocampus was involved in all three types of cue‐based navigation, whereas the striatum was more strongly recruited in the presence of geometric cues than object or feature cues. We also found that unique, specific neural signatures were associated with each spatial cue. Object‐based navigation elicited a widespread pattern of activity in temporal and occipital regions relative to feature‐based navigation. These findings extend the current view of a dual, juxtaposed hippocampal–striatal system for visual spatial coding in humans. They also provide novel insights into the neural networks mediating object versus feature spatial coding, suggesting a need to distinguish these two types of landmarks in the context of human navigation.
Metabolic dysfunction‐associated fatty liver disease and excessive alcohol consumption are both independent risk factors for mortality
Authors: van Kleef Laurens A. , de Knegt Robert J. , Brouwer Willem Pieter 
Published: July 2022

Background and Aims:
MAFLD often cooccurs with excessive alcohol consumption, while its prognostic value in this group remains unclear. We aimed to study the mortality risk of MAFLD in relation to excessive alcohol consumption and its potential interactions.

Approach and Results:
We analyzed persons 25–74 years old enrolled in the National Health and Nutrition Examination Survey III cohort with available steatosis and alcohol data. Participants with viral hepatitis, body mass index < 18.5, and missing data on age or follow‐up were excluded, leaving 12,656 participants for analysis with a median follow‐up of 22.9 [20.9–24.8] years. MAFLD was defined as steatosis on ultrasound in the presence of metabolic dysfunction. Daily alcohol intake of ≥10 g in females and ≥20 g in males was considered excessive alcohol consumption. We quantified mortality risk with multivariate Cox regression for MAFLD and excessive alcohol consumption. Models were adjusted for age, age squared, sex, race, marital status, education, and smoking. MAFLD was present in 31% and excessive alcohol consumption in 13% and were both independently and simultaneously associated with increased mortality risk in fully adjusted models (adjusted HR [aHR], 1.21; 95% CI, 1.13–1.30 and aHR, 1.14; 95% CI, 1.04–1.26, respectively). Similarly, MAFLD was associated with increased mortality risk in participants with and without excessive alcohol consumption. Participants with both MAFLD and excessive alcohol consumption (4.0%) expressed the highest mortality risk (aHR, 1.47; 95% CI, 1.28–1.71). Results were consistent using the initial 10 years of follow‐up, a stringent definition of excessive alcohol, and propensity score weighting.

Conclusions:
MAFLD increases mortality risk independent of excessive alcohol consumption. This underscores the importance of MAFLD, even in patients with excessive alcohol consumption.
Mitohormesis and mitochondrial dynamics in the regulation of stem cell fate
Authors: Barzegari Abolfazl , Aaboulhassanzadeh Sobhan , Landon Rebecca , Gueguen Virginie , Meddahi‐Pellé Anne , Parvizpour Sepideh , Anagnostou Fani , Pavon‐Djavid Graciela 
Published: July 2022

AbstractThe ability of stem cells for self‐renewing, differentiation, and regeneration of injured tissues is believed to occur via the hormetic modulation of nuclear/mitochondrial signal transductions. The evidence now indicates that in damaged tissues, the mitochondria set off the alarm under oxidative stress conditions, hence they are the central regulators of stem cell fate decisions. This review aimed to provide an update to a broader concept of stem cell fate in stress conditions of damaged tissues, and insights for the mitochondrial hormesis (mitohormesis), including the integrated stress response (ISR), mitochondrial dynamics, mitochondria uncoupling, unfolded protein response, and mitokines, with implications for the control of stem cells programing in a successful clinical cell therapy.
Amelioration of inflammatory myopathies by glucagon‐like peptide‐1 receptor agonist via suppressing muscle fibre necroptosis
Authors: Kamiya Mari , Mizoguchi Fumitaka , Yasuda Shinsuke 
Published: July 2022

AbstractBackgroundAs glucocorticoids induce muscle atrophy during the treatment course of polymyositis (PM), novel therapeutic strategy is awaited that suppresses muscle inflammation but retains muscle strength. We recently found that injured muscle fibres in PM undergo FASLG‐mediated necroptosis, a form of regulated cell death accompanied by release of pro‐inflammatory mediators, contributes to accelerate muscle inflammation and muscle weakness. Glucagon‐like peptide‐1 receptor (GLP‐1R) agonists have pleiotropic actions including anti‐inflammatory effects, prevention of muscle atrophy, and inhibition of cell death, in addition to anti‐diabetic effect. We aimed in this study to examine the role of GLP‐1R in PM and the effect of a GLP‐1R agonist on in vivo and in vitro models of PM.MethodsMuscle specimens of PM patients and a murine model of PM, C protein‐induced myositis (CIM), were examined for the expression of GLP‐1R. The effect of PF1801, a GLP‐1R agonist, on CIM was evaluated in monotherapy or in combination with prednisolone (PSL). As an in vitro model of PM, C2C12‐derived myotubes were treated with FASLG to induce necroptosis. The effect of PF1801 on this model was analysed.ResultsGLP‐1R was expressed on the inflamed muscle fibres of PM and CIM. The treatment of CIM with PF1801 in monotherapy (PF) or in combination with PSL (PF + PSL) suppressed CIM‐induced muscle weakness (grip strength, mean ± SD (g); PF 227 ± 6.0 (P < 0.01), PF + PSL 224 ± 8.5 (P < 0.01), Vehicle 162 ± 6.0) and decrease in cross‐sectional area of muscle fibres (mean ± SD (μm2); PF 1896 ± 144 (P < 0.05), PF + PSL 2018 ± 445 (P < 0.01), Vehicle 1349 ± 199) as well as the severity of histological inflammation scores (median, interquartile range; PF 0.0, 0.0–0.5 (P < 0.05), PF + PSL 0.0, 0.0–0.0 (P < 0.01), Vehicle 1.9, 1.3–3.3). PF1801 decreased the levels of inflammatory mediators such as TNFα, IL‐6, and HMGB1 in the serum of CIM. PF1801 inhibited necroptosis of the myotubes in an AMP‐activated protein kinase (AMPK)‐dependent manner. PF1801 activated AMPK and decreased the expression of PGAM5, a mitochondrial protein, which was crucial for necroptosis of the myotubes. PF1801 promoted the degradation of PGAM5 through ubiquitin‐proteasome activity. Furthermore, PF1801 suppressed FASLG‐induced reactive oxygen species (ROS) accumulation in myotubes, also crucial for the execution of necroptosis, thorough up‐regulating the antioxidant molecules including Nfe2l2, Hmox1, Gclm, and Nqo1.ConclusionsGLP‐1R agonist could be a novel therapy for PM that recovers muscle weakness and suppresses muscle inflammation through inhi biting muscle fibre necroptosis.
Role of catalyst supports in biocatalysis
Authors: Manikandan Soumya Koippully , Giannakoudakis Dimitrios A. , Prekodravac Jovana R , Nair Vaishakh , Colmenares Juan Carlos 
Published: July 2022

AbstractBiocatalysis utilizes enzymes and microbial cells as catalysts for a wide range of applications in biotechnology. Immobilization of biocatalysts on various materials has several advantages, including the capacity for reuse, quick reaction termination, easy biocatalyst recovery and operational stability. The present article focuses on the use of material supports for developing immobilized biocatalysts in applications related to energy, environment and chemical synthesis. The work provides a comprehensive overview of a broad class of materials, including organic, inorganic and composites, that have been shown to be prosperous candidates to support the immobilization of enzymes and microbial cells. It also highlights the properties of nanomaterial support such as large surface area and comfort compartment for immobilization. The availability of different types of materials as catalyst support provides an opportunity to understand and develop efficient biocatalytic systems. The choice of selecting a catalyst support will mostly depend on the interaction of the material with the enzyme or microbial cell. Finally, potential challenges, future approaches in developing immobilized biocatalytic systems for various applications and novel material supports are suggested. © 2022 Society of Chemical Industry (SCI).
HIV drug resistance in a community‐randomized trial of universal testing and treatment: HPTN 071 (PopART)
Authors: Fogel Jessica M. , Wilson Ethan A. , Piwowar‐Manning Estelle , Breaud Autumn , Clarke William , Petropoulos Christos , Moore Ayana , Fraser Christophe , Kosloff Barry , Shanaube Kwame , van Zyl Gert , Scheepers Michelle , Floyd Sian , Bock Peter , Ayles Helen , Fidler Sarah , Hayes Richard , Donnell Deborah , Eshleman Susan H. ,   for the HPTN 071 (PopART) Study Team
Published: July 2022

AbstractIntroductionUniversal HIV testing and treatment (UTT) has individual and public health benefits. HPTN 071 (PopART), a community‐randomized trial in Zambia and South Africa, demonstrated that UTT decreased HIV incidence. This endpoint was assessed in a cohort of >48,000 randomly selected adults in the study communities. We evaluated the impact of UTT on HIV drug resistance in this cohort and compared other resistance‐related outcomes in participants with recent versus non‐recent HIV infection.MethodsTwo years after the start of HPTN 071 (2016–2017), 6259 participants were HIV positive and 1902 were viremic (viral load >400 copies/ml). HIV genotyping and antiretroviral (ARV) drug testing were performed for viremic participants in three groups: seroconverters (infected <1 year), non‐seroconverters (infected >1 year, random subset) and participants with unknown duration of infection (random subset). A two‐stage cluster‐based approach was used to assess the impact of the study intervention on drug resistance. Treatment failure was defined as being viremic with ARV drugs detected. Participants were classified as ARV naïve based on self‐report and ARV drug testing.ResultsGenotyping results were obtained for 758 participants (143 seroconverters; 534 non‐seroconverters; and 81 unknown duration of infection). The estimated prevalence of resistance in the study communities was 37% for all viremic persons and 11% for all HIV‐positive persons. There was no association between UTT and drug resistance. Resistance was detected in 14.0% of seroconverters and 40.8% of non‐seroconverters (non‐nucleoside reverse transcriptase inhibitor resistance: 14.0% and 39.9%; nucleoside/nucleotide reverse transcriptase inhibitor resistance: 0.7% and 15.5%; protease inhibitor resistance: 0% and 1.9%; multi‐class resistance: 0.7% and 16.1%, respectively). ARV drugs were detected in 2/139 (1.4%) of seroconverters and 94/534 (17.6%) of non‐seroconverters tested. These participants were classified as failing ART; 88 (93.6%) of the non‐seroconverters failing ART had resistance. Mutations used for surveillance of transmitted drug resistance were detected in 10.5% of seroconverters and 15.1% of non‐seroconverters who were ARV naive.ConclusionsUTT was not associated with an increase in drug resistance in this cohort. Higher rates of drug resistance and multi‐class resistance were observed in non‐seroconverters compared to seroconverters.
What Factors Influence Children's Creative Artistic Orientation? The NovelChildren's Creative Orientation Test: Artistic
Authors: Simner Julia , Smees Rebecca , Rinaldi Louisa J. , Carmichael Duncan A. , McDonald Toby J. 
Published: July 2022

ABSTRACTCreative orientation is the extent to which different individuals are drawn toward creative activities (e.g., art, music). We know relatively little about child‐level creative orientation given certain testing limitations. Adult tools often measure time spent engaged in creative pursuits, but this method is unsuitable for children because their free time is often dictated by parents. To overcome this, we devised an entirely novel measure of creative orientation, theChildren's Creative Orientation Test: Artistic (C‐COT: Artistic). This short task, suitable for children as young as 6, elicits children's creative urges toward artistic pursuits independently of parental influence and provides quantitative scoring. We applied our measure to over 3000 children aged 6–10 years, where it showed robust reliability, suggesting that creative orientation is a stable trait over time. We show that creative orientation is also influenced by classroom cohort, age, and gender but is unaffected by socio‐economic status or seasonal changes (autumn vs. spring testing). We showed too that creative orientation converges with creative thinking (divergent thinking), creative personality (openness to experiences, especially the aesthetics subtrait), and creative engagements in the home. We present our test here in full, as a simple, fast, and robust measure of creative artistic orientation in children.
Associations among civilian mild traumatic brain injury with loss of consciousness, posttraumatic stress disorder symptom trajectories, and structural brain volumetric data
Authors: Kosaraju Siddhartha , Galatzer‐Levy Isaac , Schultebraucks Katharina , Winters Sterling , Hinrichs Rebecca , Reddi Preethi J. , Maples‐Keller Jessica L. , Hudak Lauren , Michopoulos Vasiliki , Jovanovic Tanja , Ressler Kerry J. , Allen Jason W. , Stevens Jennifer S. 
Published: July 2022

AbstractPosttraumatic stress disorder (PTSD) is prevalent and associated with significant morbidity. Mild traumatic brain injury (mTBI) concurrent with psychiatric trauma may be associated with PTSD. Prior studies of PTSD‐related structural brain alterations have focused on military populations. The current study examined correlations between PTSD, acute mTBI, and structural brain alterations longitudinally in civilian patients (N = 504) who experienced a recent Criterion A traumatic event. Participants who reported loss of consciousness (LOC) were characterized as having mTBI; all others were included in the control group. PTSD symptoms were assessed at enrollment and over the following year; a subset of participants (n = 89) underwent volumetric brain MRI (M = 53 days posttrauma). Classes of PTSD symptom trajectories were modeled using latent growth mixture modeling. Associations between PTSD symptom trajectories and cortical thicknesses or subcortical volumes were assessed using a moderator‐based regression. mTBI with LOC during trauma was positively correlated with the likelihood of developing a chronic PTSD symptom trajectory. mTBI showed significant interactions with cortical thickness in the rostral anterior cingulate cortex (rACC) in predicting PTSD symptoms, r = .461–.463. Bilateral rACC thickness positively predicted PTSD symptoms but only among participants who endorsed LOC, p < .001. The results demonstrate positive correlations between mTBI with LOC and PTSD symptom trajectories, and findings related to mTBI with LOC and rACC thickness interactions in predicting subsequent chronic PTSD symptoms suggest the importance of further understanding the role of mTBI in the context of PTSD to inform intervention and risk stratification.
Incoherent Optoelectronic Differentiation Based on Optimized Multilayer Films
Authors: Zhang Xiaomeng , Bai Benfeng , Sun Hong‐Bo , Jin Guofan , Valentine Jason 
Published: July 2022

AbstractFourier‐based optical computing operations, such as spatial differentiation, have recently been realized in compact form factors using flat optics. Experimental demonstrations, however, have been limited to coherent light requiring laser illumination and leading to speckle noise and unwanted interference fringes. Here, the use of an optimized multilayer film, combined with dual color image subtraction, is demonstrated to realize differentiation with unpolarized incoherent light. Global optimization is achieved by employing neural networks combined with the reconciled level set method to optimize the optical transfer function of a multilayer film at wavelengths of 532 and 633 nm. Spatial differentiation is then achieved by subtracting the normalized incoherent images at these two wavelengths. The optimized multilayer film is experimentally demonstrated to achieve incoherent differentiation with a resolution of 6.2 m. The use of a multilayer film allows for scalable lithography‐free fabrication and results in a system that could open the door to high‐speed processing for a wide variety of incoherent, and coherent, imaging systems.