bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hepatitis C Prevalence, Incidence, and Treatment in Chinese Hemodialysis Patients: Results From the Dialysis Outcomes and Practice Patterns Study-China (2019–21)
Authors: Gan Liangying , Wang Dongyu , Bieber Brian , McCullough Keith , Jadoul Michel , Pisoni Ronald L. , Hou Fanfan , Liang Xinling , Ni Zhaohui , Chen Xiaonong , Chen Yuqing , Zuo Li 
Published: June 2022

BackgroundPrior work from the Dialysis Outcomes and Practice Patterns Study (DOPPS) showed HCV prevalence in China in 2012–2015 being in the upper third and HCV incidence the 2nd highest among 15 different countries/regions investigated. The goal of the present investigation was to: (1) determine if HCV prevalence and incidence has changed, and (2) collect detailed data to understand how HCV is treated, monitored, and managed in Chinese HD facilities and non-dialysis chronic kidney disease (CKD) clinics.Data and MethodsDetailed data for 1,700 randomly selected HD patients were reported by 39 randomly selected HD facilities from Beijing, Shanghai, and Guangzhou participating in the DOPPS 7-China study from 2019 to 2021. The study site medical directors completed a survey regarding numerous aspects of HCV treatment and management in HD and ND-CKD patients.ResultsIn this 2019 to 2021 cohort, HCV prevalence was 7.4%, which was lower than the 14.8 and 11.5% HCV prevalence for the 2009–2011 and 2012–2015 cohorts, respectively. HCV incidence of 1.2 cases per 100 pt-yrs also was lower compared to the incidence of 2.1 for the 2012–2015 cohort. Although the great majority of study site medical directors indicated that all or nearly HCV+ patients should be treated for their HCV, very few HCV+ patients have been treated presumably due to substantial cost barriers for affording the new direct acting antivirals (DAAs). The randomly selected facilities in our DOPPS 7-China study appear to have excellent programs in place for frequent monitoring of patients and staff for HCV, education of staff, and referral of HCV cases to external infectious disease, gastroenterology, and liver disease specialists. Liver biopsies were not commonly performed in HCV+ HD patients. HCV genotyping also was rarely performed in participating units.ConclusionsOur study indicates a 50% decline in HCV prevalence and a &gt;40% decline in HCV incidence in Chinese HD patients over the past 10–12 yrs. Chinese HD facilities and associated specialists appear to be well-equipped and organized for successfully treating and managing their HCV+ HD and CKD patients in order to achieve the WHO goal of eliminating HCV by 2030.
Fungal Endophthalmitis in a Case of Rhino-Orbito-Cerebral Mucormycosis: Successfully Treated With Amphotericin B Colloidal Dispersion
Authors: Zhao Yinlong , Tian Wenbin , Yang Jiankai , Li Xueqing , Lu Huaihai , Yu Ning , Zhang Pei , Liu Chao , Chen Pengfei , Lei Guang , Liu Ya 
Published: June 2022

BackgroundRhino-orbito-cerebral mucormycosis (ROCM) is an acute, fulminant, opportunistic fungal infection that usually occurs in diabetes or immunocompromised patients. Amphotericin B combined with surgical debridement remains the standard treatment, although it is controversial due to its lager nephrotoxicity. Thus far, no studies have reported the treatment for ROCM-associated fungal endophthalmitis because the exact pathogenesis and transmission routes in ROCM remain unclear. Here, we reported a case of ROCM complicated with fungal endophthalmitis treated favorably with amphotericin B colloidal dispersion (ABCD) in combination with other antifungals and surgical debridement.Case PresentationA 34-year-old woman with diabetes was admitted to our hospital owing to right-sided headache for 8 days, blindness with swelling in the right eye for 5 days, and blindness in the left eye for 1 day. MRI showed that the patient had sphenoid sinus, sinuses, frontal lobe lesions, and proptosis of the right eye. Metagenomic sequencing revealed that the patient had Rhizopus oryzae infection. During hospitalization, the patient received intravenous ABCD, oral posaconazole, and topical amphotericin B and underwent surgical debridement. After 67 days of treatment, the patient’s condition was significantly improved, and limb muscle strength showed grade V. Rhizopus oryzae showed negative results, and conjunctival swelling decreased. Additionally, no nephrotoxicity occurred during treatment. After discharge, the patient’s treatment was transitioned to oral posaconazole and she was free of complaints during the 30-day follow-up without any additional treatment for ROCM.ConclusionTreatment with ABCD combined with other antifungal drugs and surgical debridement for ROCM complicated with fungal endophthalmitis showed remarkable efficacy and good safety. Hence, this regimen is a promising treatment strategy for this fatal disease.
Effect Western Medicines Combined With Nao-Xue-Shu in Patients With Hypertensive Intracerebral Hemorrhage: A Network Meta-Analysis
Authors: Mei Li , Fengqun Mu , Xiaozhuo Liu , Qing Wang , Mingming Fan , Zhengyao Zuo , Dongpo Su , Qian Han , Tong Chen 
Published: June 2022

Purpose: To explore the efficacy of nimodipine, nifedipine, and edaravone (EDA) combined with Nao-Xue-Shu in patients with hypertensive intracerebral hemorrhage (HICH) and to determine the best western medicine combined with Nao-Xue-Shu for treating HICH patients using a ranking method.Methods: After a comprehensive search of the China National Knowledge Infrastructure (CNKI), Wanfang Database, VIP information database, Chinese Biomedical Database (CBM), PubMed, Embase, and Cochrane Library database from the database establishment 31 December 2021, data extraction and quality assessment were conducted for the included articles. The primary outcome measure was the effectiveness after treatment. Secondary outcome measures were after-treatment the National Institutes of Health Stroke Scale (NIHSS) scores, hematoma volume, perihematoma edema volume, and inflammatory factor expression levels. Statistical analyses were performed using Stata 16.0 and RevMan 5.3.0 software.Results: We included 19 randomized controlled trials (RCTs) and six non-RCTs. The effective rate after treatment was ranked from the best to the worst as follows: routine cure measure (RCM) + nifedipine + Nao-Xue-Shu, RCM + EDA + Nao-Xue-Shu, RCM + Nao-Xue-Shu, RCM + nimodipine + Nao-Xue-Shu, RCM + EDA, and RCM. The post-treatment NHISS scores from lowest to highest were as follows: RCM + EDA + Nao-Xue-Shu, RCM + nifedipine + Nao-Xue-Shu, RCM + EDA, RCM + nimodipine + Nao-Xue-Shu, RCM + Nao-Xue-Shu, RCM + Nao-Xue-Kang, and RCM. The post-treatment hematoma volume from minimum to maximum was as follows: RCM + EDA + Nao-Xue-Shu, RCM + nimodipine + Nao-Xue-Shu, RCM + nifedipine + Nao-Xue-Shu, RCM + Nao-Xue-Shu, RCM + Nao-Xue-Kang, and RCM. The post-treatment perihematoma edema volume from minimum to maximum was as follows: RCM + EDA + Nao-Xue-Shu, RCM + nifedipine + Nao-Xue-Shu, RCM + nimodipine + Nao-Xue-Shu, RCM + Nao-Xue-Shu, and RCM. For inflammatory factor expression levels after treatment, IL-6 concentration levels after treatment from lowest to highest wasas follows: RCM + Nao-Xue-Shu, RCM + nifedipine + Nao-Xue-Shu, RCM + nimodipine + Nao-Xue-Shu, RCM + EDA + Nao-Xue-Shu, and RCM. TNF-α concentration levels after treatment from lowest to highest was as follow: RCM + nimodipine + Nao-Xue-Shu, RCM + nifedipine + Nao-Xue-Shu, RCM + Nao-Xue-Shu, and RCM.Conclusion: Nao-Xue-Shu combined with nifedipine showed better effectiveness after treatment in HICH patients compared with the other combinations. Nao-Xue-Shu combined with EDA was more effective for improving neurological function and reducing both hematoma and edema volumes around the hematoma compared with the other combinations. However, Nao-Xue-Shu alone or Nao-Xue-Shu combined with nimodipine may be more effective for reducing proinflammatory factor expression.
A Worldwide Bibliometric Analysis of Tetrandrine Research in Recent Two Decades
Authors: Yang Guang , Xie Wenqing , Ding Yilan , Wang Weiyang , Huang Cheng , Zhao Tingxiao , Li Yusheng 
Published: June 2022

Background: Tetrandrine has been the focus of many studies in recent years. Currently, no bibliometric study in this field has been published. This study presents a bibliometric analysis of the articles on tetrandrine research from the WOS core database during the recent two decades.Methods: Documents were retrieved for further bibliometric analysis based on the search terms: [TI = (Tetrandrine OR Sinomeninea OR Hanfangchin A) AND PY = (2000–2021)]. We used Microsoft Excel to conduct the frequency analysis, VOSviewer for data visualization, and RStudio for citation metrics and analysis. The standard bibliometric indicators such as the temporal trends and geographical distribution of publications and citations, prolific authors and co-authorship, keywords citation burst, preferred journals, top-cited articles, and important institutions were applied in this study.Results: 490 documents were retrieved from WOS core database, the retrieved document type consists of 8 categories: 425 articles, 42 meeting abstracts, 8 reviews, 7 corrections, 3 editorial material, 2 proceedings paper, 1 letter, 1 retraction. Corrections and Retractions was excluded from this investigation, the left 482 document were included for furter bibliometric analysis.Conclusion: Based on our findings, there was a continuous growth of publications on tetrandrine research for 22 years since 2000. China was the largest contributor to tetrandrine research, followed by the United States. The most influential author was Cheng Y (Natl Taiwan Univ Hosp). Acta Pharmacol Sin remained the main publication related to tetrandrine research. Chinese Academy of Sciences, is expected to be a good collaborating center in tetrandrine research. The use of tetrandrine in cancer treatment, could be the promising research subject areas to follow.
Psychometric Properties of Four Common Clinical Tests for Assessing Hamstring Flexibility in Young Adults
Authors: Liu Hao , Shen Ying , Xiong Yuan , Zhou Hongfei , Mao Yuchen , Shen Qiangqiang , Hong Wenxia , Liu Mingjian , Liu Yanqian , Qiu Li , Zhang Zhijie , Jia Yanbing 
Published: June 2022

Objective: To examine the psychometric properties of four common hamstring muscle flexibility tests involving the straight leg raise (SLR), passive knee extension (PKE), sit and reach test (SRT) and toe touch test (TTT) in young adults.Methods: Forty-three young healthy adults (mean age 27.4 years) were recruited for 3 repeated sessions of hamstring flexibility assessments using the 4 tests mentioned above and the subsequent isokinetic examinations. The first two sessions (S1 and S2) were conducted by two different raters randomly on the first day (D1), and the third session (S3) was conducted by the same rater as S1 3 days later (D4). The next day (D5), the isokinetic performances of knee extensors and flexors of the dominant leg were assessed. To evaluate the interrater (S1 vs. S2) and test-retest (S1 vs. S3) reliability of hamstring flexibility tests, intraclass correlation coefficients (ICCs), standard errors of measurement, and the minimum detectable differences were calculated. Correlation analyses were performed to study the association of each hamstring flexibility test with the isokinetic muscle function of the knee flexors (H) and extensors (Q), including the peak torque (PT), total amount of work (TW) and average power (AP).Results: Excellent interrater and test-retest reliability of hamstring flexibility tests involving the SLR, PKE, SRT and TTT were confirmed with ICCs ranging from 0.923 to 0.986. Fair correlations were found between the 4 hamstring flexibility tests and the H/Q for the PT at angular speeds of 180°/s (Pearson’s r at 0.330–0.449). In addition, the PKE was fairly correlated with the AP of the hamstring (Pearson’s r = 0.320) and the H/Q for the TW (Pearson’s r = 0.345) and AP (Pearson’s r = 0.386) at angular speeds of 180°/s.Conclusions: This study confirmed that the SLR, PKE, SRT and TTT were reliable flexibility tests for hamstring muscles in young healthy adults, and the PKE might be a more valid outcome measure to predict hamstring injury.
Effects of Hydroxyurea on Skeletal Muscle Energetics and Function in a Mildly Anemic Mouse Model
Authors: Michel Constance P. , Messonnier Laurent A. , Giannesini Benoit , Chatel Benjamin , Vilmen Christophe , Le Fur Yann , Bendahan David 
Published: June 2022

Hydroxyurea (HU) is a ribonucleotide reductase inhibitor most commonly used as a therapeutic agent in sickle cell disease (SCD) with the aim of reducing the risk of vaso-occlusion and improving oxygen transport to tissues. Previous studies suggest that HU may be even beneficial in mild anemia. However, the corresponding effects on skeletal muscle energetics and function have never been reported in such a mild anemia model. Seventeen mildly anemic HbAA Townes mice were subjected to a standardized rest-stimulation (transcutaneous stimulation)-protocol while muscle energetics using 31Phosphorus magnetic resonance spectroscopy and muscle force production were assessed and recorded. Eight mice were supplemented with hydroxyurea (HU) for 6 weeks while 9 were not (CON). HU mice displayed a higher specific total force production compared to the CON, with 501.35 ± 54.12 N/mm3 and 437.43 ± 57.10 N/mm3 respectively (+14.6%, p &lt; 0.05). Neither the total rate of energy consumption nor the oxidative metabolic rate were significantly different between groups. The present results illustrated a positive effect of a HU chronic supplementation on skeletal muscle function in mice with mild anemia.
A Study on Pregenomic RNA and Factors Related to Hepatitis B Virus Infection Based on Real World
Authors: Yan Hao-Zhen , Huang Zhi-Hao , Guo Xu-Guang , Peng Ting-Ting , Yang Li-Li , Liu Chong-Wen , Ou-Yang Shi 
Published: June 2022

ObjectiveThis article aims to study the influencing factors of pgRNA and its change magnitude based on the real world.MethodsA total of 421 patients who were tested for pgRNA were selected. According to the baseline data, the subjects were divided into negative and positive groups. The Chi-square test and logistic regression were used to analyze the influencing factors of pgRNA status. Based on the follow-up data, the rank-sum test and linear regression were used to analyze the influencing factors of pgRNA change magnitude.ResultsA total of 153 (36.3%) of the 421 subjects were pgRNA-negative and 268 (63.7%) were pgRNA-positive. Logistic regression analysis showed that positive HBV DNA (OR: 40.51), positive HBeAg (OR: 66.24), tenofovir treatment (OR: 23.47), and entecavir treatment (OR: 14.90) were the independent risk factors for positive pgRNA. Univariate linear regression showed that the pgRNA change magnitude of patients treated with entecavir was higher than that of patients treated with tenofovir. Multivariate linear regression showed that age was an independent factor influencing pgRNA change magnitude.ConclusionsThe pgRNA of patients who were young, female, HBV DNA-positive, high-HBsAg, HBeAg-positive is higher than the detection line. HBV DNA and HBeAg are the independent risk factors of positive pgRNA. Different antiviral regimens and disease stages have significantly different effects on pgRNA status. There was a significant correlation between pgRNA and FIB-4, suggesting that pgRNA is related to liver fibrosis. The decrease in pgRNA was greater in young patients than in non-young patients. The decrease in pgRNA was greater in patients treated with tenofovir than in patients treated with entecavir.
Comparison of Postoperative Outcomes Between Percutaneous Endoscopic Lumbar Interbody Fusion and Minimally Invasive Transforaminal Lumbar Interbody Fusion for Lumbar Spinal Stenosis
Authors: Lin Lu , Liu Xiao-Qin , Shi Lei , Cheng Si , Wang Zhi-Qiang , Ge Qi-Jun , Gao Ding-Zhi , Ismail Amadou Cheffou , Ke Zhen-Yong , Chu Lei 
Published: June 2022

ObjectiveThis study aimed to compare postoperative outcomes in surgical and patient-reported outcomes (PROs) between percutaneous endoscopic lumbar interbody fusion (PE-LIF) and minimally invasive transforaminal lumbar interbody fusion (MIS-TLIF) for the treatment of lumbar spinal stenosis (LSS).MethodsWe reviewed a total of 89 patients undergoing single-level surgery for lumbar spinal stenosis from January 2018 to July 2021. The cases were categorized as PE-LIF (Group PE-LIF, 41 cases) or MIS-TLIF (Group MIS-TLIF, 48 cases) approach. Parameters obtained at baseline through at least six months of follow-up were collected. The surgical outcomes involving the operative time, estimated blood loss, postoperative bed staying time, and length of hospital stays were analyzed. PROs included the Visual Analogue Scale (VAS), Oswestry Disability Index (ODI), modified MacNab standard evaluation, intervertebral fusion rate, and postoperative complications.ResultsA total of 89 patients were included in this analysis involving 41 patients who underwent PE-LIF and 48 patients who underwent MIS-TLIF. The 2 groups were similar in gender, age, body mass index, follow-up time and surgery levels (P &gt; 0.05), and were not significantly different in the length of hospital stays (P &gt; 0.05). PE-LIF had a significantly longer operative time, greater fluoroscopy time, lower estimated blood loss and shorter bed rest time than MIS-TLIF. Both groups improved significantly from baseline for the VAS and ODI scores. PE-LIF was associated with a lower VAS score for back pain at three-day after surgery. There were no significant differences between PE-LIF and MIS-TLIF in the excellent or good rates and intervertebral fusion rates at the last follow-up (P &gt; 0.05). As for related complications, there were no significant complications occurred, and no significant differences were seen in the complications between both groups (P &gt; 0.05).ConclusionsTo summarize, PE-LIF and MIS-TLIF are both safe and effective for LSS. PE-LIF has a definite short-term curative effect with less trauma.
TOMATO FRUIT QUALITY BETWEEN CLUSTERS IS DIFFERENTIALLY AFFECTED BY NITROGEN AND POTASSIUM SUPPLY
Authors: San-Martín-Hernández Cesar , Gómez-Merino Fernando C. , Rivera-Vargas Giovanna , Saucedo-Veloz Crescenciano , Vaquera-Huerta Humberto , Trejo-Téllez Libia I. 
Published: June 2022

Fruit quality is significantly affected by the nutrient status of plants; nonetheless, it has not yet been deeply explored how nitrogen (N) and potassium (K) supply affects tomato fruit quality between clusters during the vegetative and reproductive stages of the crop. The aim of this study was to evaluate the effects of N and K on fruit quality parameters of three clusters of hydroponically grown tomato (Solanum lycopersicum L.). Nitrogen (10, 12, 14 and 16 molc N m-3) was evaluated at the vegetative stage, and potassium (5, 7, 9, 11 and 13 molc K m-3) at the reproductive stage. The evaluated N and K concentrations showed significant main effects on the quality attributes total soluble solids, citric acid percentage, reducing sugars, color and lycopene concentration; yield was affected only by K, while the effects of N × K interaction were not significant. Increasing N concentrations from 10 to 16 molc m-3 enhanced hue angle, brightness, reducing sugars and citric acid percentage, but decreased total soluble solids and lycopene. As K increased from 5 to 13 molc m-3 in the nutrient solution, total soluble solids, citric acid, reducing sugars, lycopene, yield and fruit brightness increased, but hue decreased. Total soluble solids, reducing sugars and lycopene gradually increased from the first to the fifth cluster, while yield, color attributes of hue and brightness tended to decrease as the crop cycle progressed. Titratable acidity percentage showed no clear trends between clusters. It is concluded that N and K differentially affect tomato quality between clusters.
EFFECT OF Planococcus ficus (SIGNORET) ON THE GROWTH OF THREE WINE GRAPE CULTIVARS
Authors: Castillo Guillermo , Bello-Bedoy Rafael 
Published: June 2022

Damage caused by herbivores reduces plant survival and growth through its effects on mechanisms involved in tolerance to herbivory. Infestation by sap-sucking insects negatively affects the expression of metabolites related to photosynthesis and growth traits, which in an agricultural context can be useful for designing pest management and crop breeding programs. The effect of infestation by the vine mealybug Planococcus ficus (Signoret) (Hemiptera: Pseudococcidae) on chlorophyll content and plant growth in three varieties of Vitis vinifera L. (Garnacha, Tempranillo and Nebbiolo) was evaluated. A common garden experiment was conducted with 60 plants of each variety and two P. ficus infestation treatments (infested and non-infested). Plant height, number of leaves, leaf area and chlorophyll content index were measured before and after P. ficus infestation for each plant and, additionally, the relative change rate (RCR) for each trait was estimated. The infestation reduced theRCR of the number of leaves (22.57 %) and leaf area (41.65 %). The effect of infestation on plant growth changed between varieties. Nebbiolo plants with infestation showed a reduction of RCR in plant height compared to non- infested plants (57.32 %), while Garnacha and Tempranillo varieties showed similar values in both treatments. A negative effect of P. ficus infestation on plant height, number of leaves and leaf area was found. Results suggest that the Nebbiolo variety is less tolerant to P. ficus attack. Farmers should adopt more rigorous monitoring and control measures when growing this variety.
Hubungan antara Pendidikan dan Pendapatan Dengan Kesiapan Persalinan Ibu Hamil Di Masa Pandemi Covid-19
Authors: Ana Sapitri  , Maria Septiana  
Published: June 2022

Di Indonesia, Angka Kematian Ibu dan Neonatal masih menjadi tantangan besar dan perlu mendapatkan perhatian dalam situasi bencana COVID-19, Pada masa epidemi banyak terjadi peningkatan jumlah ibu dan bayi baru lahir yang menderita komplikasi atau meninggal dalam hamil, persalinan, dan periode pasca kelahiran hal ini disebabkan oleh penurunan akses serta pemanfaatan layanan esensial kesehatan ibu dan bayi baru lahir.Pada kehamilan memasuki trimester ketiga, poin penting terletak pada persiapan ibu dalam menghadapi persalinan. Persiapan persalinan pada ibu meliputi persiapan fisik dan fisikologis. Ketidaksiapan ibu menghadapi persalinan menjadi salah satu faktor penyebab tingginya angka kematian ibu (AKI) dan angka kematian bayi (AKB). Tujuan Penelitian ini adalah untuk mengetahui Hubungan antara Pendidikan dan Pendapatan dengan kesiapan persalinan ibu di masa pandemi Covid 19. Desain penelitian ini adalah Cross Sectional. Teknik pengambilan sampel menggunakan Total Sampel yaitu semua ibu hamil Trimester III yang datang untuk melakukan pemelriksaan ANC di Puskesmas Cambai pada saat penelitian dengan jumlah sampel 36 orang. Instrumen penelitian berupa kuesioner kesiapan persalinan ibu hamil di masa pandemi Covid 19. Analisa data dilakukan secara univariat dan bivariate. Dari hasil penelitian didapatkan responden dengan menopause sebanyak 7 responden (19,4%) dengan tidak siap dan 29 responden (80,6) Siap. Pendapatan UMK didapatkan 8 responden (22,2%) dan Di Atas UMK 28 responden (77,8%). Pendidikan Tinggi didapatkan 31 responden (86,1%) Pendidikan Rendah 5 responden (13,9%). Dari hasil uji Chi-Square menyatakan bahwa ada hubungan yang bermakna antara Pendidikan dan Pendapatan dengan kesiapan Persalinan Ibu hamil pada masa pandemic COVID-19. Disarankan bagi tenaga kesehatan untuk lebih meningkatkan pelayanan kesehatan dan penyuluhan tentang Pesalinan Pada Masa COVID-19.