bluuebunny/crossref_metadata_2025_split huggingface dataset:
Miliary Tuberculosis with Cutaneous Affectations and SARS-CoV-2 Coinfection in Infant: Case Report in Mexico
Authors: Reyes Ivonne Juarez , Vidal Jose Alfredo Vidal , Tellez Virginia Lora , Hernandez Ma. Fabiola Del Carmen Lara , Macip Magdalena Molina , Hernandez Alejandra Silva , Guillen Patricia Daniela Gogeascoechea , Zepeda Brenda Mariel Valerdi , Peraza Angie Giovanna Velasco , González Froylan Eduardo Hernandez Lara 
Published: February 2022

Aims: To describe an infant presenting with miliary tuberculosis with cutaneous affectations and SARS-CoV-2 coinfection.
Presentation of Case: 10 month old boy, with incomplete vaccination. Low Socio-economic status. The parents indicated, that lesion began with a single small, erythematous, non-pruritic, papule-type skin lesion on the left side of the infralabial region, with no other constitutional. During the following three months, the lesions became generalized. On June 23, 2020, he was admitted to the “Hospital para el Niño Poblano” in emergency area with mild malnutrition, lethargic state, fluid and electrolyte imbalance, metabolic acidosis, oral candidiasis, and septic shock, requiring endotracheal intubation. Besides, innumerable acid fast bacilli in skin biopsy and bronchial aspirate with diagnosis cutaneous TB was, identified. Immunodeficiency based on immunoglobulin profile and T and B cell markers. RT-PCR was performed for SARS-CoV-2 in bronchial aspirate, with a positive result. On June 25, 2020 died of cardiorespiratory arrest, secondary to septic shock and cutaneous tuberculosis.
Discussion: Miliary TB in infants is difficult to diagnose in addition the cutaneous manifestation has added onto the long list of differentials, and downplay others, generating inappropriate and delayed treatment. Additionally, SARS-CoV-2 can intensify the clinical manifestations of miliary tuberculosis and directly influencing the mortality of this type of patients.
Conclusion: The case described is rare, which reveals the importance to perform a differentiated diagnosis, considering Socio-economic and epidemiological context mainly in the first level of care. It is recommended to continue with research in order to generate information on the possible clinical pictures.
A Study of Clinical Profile and Outcome of Status Epilepticus in Children Aged 1 Month to 18 Years
Authors: Maheswara Y. , Vagha Jayant 
Published: February 2022

Background: A common neurological emergency in children is Status epilepticus which, if not treated immediately, may trigger marked neuro morbidity and mortality and hence will need immediate and aggressive management. The neurological outcome worsens in a child as the time taken to control seizures increases and it becomes harder to terminate the seizures. This attempts to explain clinical profile and development of children with convulsive status epilepticus coming to rural hospital in central India and assess the effect of drugs used for treatment of status epilepticus.
Methodology: This Prospective Cross-sectional Study will be conducted in the paediatric intensive care unit Department of Paediatrics, PICU, AVBRH, Wardha. Parameters like clinical presentations, clinical signs, duration and types of status epilepticus, investigations used to diagnose status epilepticus, drugs (anti-epileptic drugs), immediate outcome, effect of drugs used to control seizures will be recorded. Data will be analysed using Chi- square test and independent t-test as applicable. Univariate analysis will be used for testing the influence of different variables in the outcome of present study.
Expected Results: Many factors like age, type and time period of status epilepticus, cause, treatment and corresponding comorbidities determine the end result in status epilepticus. From this study, we expect to get significant evidences to explain profile of cases of convulsive status epilepticus.
Conclusion: Outcomes of status epilepticus are determined by factors like age, time period, cause, treatment and associated comorbidities.
Analysing the Role of Platelet Rich Plasma As Biological Stimulator for Cartilage Regeneration: An Experimental Study
Authors: Chhatbar Kuldeep , Srivastava Sandeep 
Published: February 2022

Background: In articular cartilage defects and degenerative cartilage lesions, platelet-rich plasma(PRP) is increasingly used. PRP is an autologous concentration of platelets containing a high number of factors which are responsible for growth. In the healing, recovery and acceleration of biochemical processes, these growth factors play a role in reducing the pain associated with joint injuries. The latest world research shows excellent results in reducing pain by using PRP and it has tremendous scope in reducing the knee pain as well as in regeneration of the articular cartilage. This study aims to analyse the effectiveness of Autologous PRP as biologic stimulator for Cartilage Regeneration in Rabbit Model.
Method: This will be a prospective experimental study carried out on 10 rabbits at Animal House in JNMC, Wardha. Osteoarthritis will be induced in the rabbits by destruction of articular cartilage. Then platelet rich plasma therapy. Will be given to induce the regeneration of the cartilage.
Expected Results: Evidence of regeneration of articular cartilage in rabbits with osteoarthritis through Platelet Rich Plasma Therapy.
Study Protocol for Process Evaluation of Health and Wellness Center Programme in Bhandara District of Maharashtra
Authors: Ambekar Shrikant Madhukar , Quazi S. Z. , Gaidhane Abhay , Uikey Prashant 
Published: February 2022

Background: Ayushman Bharat programme, which was started by Government of India in 2018-19, has two components. First component is up gradation of existing primary health centres and sub centres in to Health and Wellness centers (HWCs), which will deliver comprehensive primary health care services at government facility level in rural area within no more than 30 minutes. Non-Communicable disease services is the integral part of comprehensive primary care. This study aims to assess availability and readiness of Health and Wellness centres at sub centres for provision of Non communicable disease Services in rural area of Bhandara district and to assess utilization of Non communicable disease Services in rural area of Bhandara district.
Methodology: This implementation research will be conducted in Health and Wellness Sub centers from rural areas of Bhandara district. It will include the facility assessment of Sub centers. Household survey will be conducted by a stratified multi-stage sampling design using Digital questionnaire Standardized and validated Facility survey Tool, Service delivery Tool and Household survey Tools. Data will be analyzed using STATA-14 software.
Expected Results: Increase in coverage and utilization of Non communicable disease Services in Health and Wellness Centre Subcenters in rural area and reduction in out of pocket expenditure of villagers is expected.
Conclusion: The proposed component of NCD services matches well with health and wellness programme targets in district and is helpful in delivery of non-communicable disease services in rural areas.
Analysis of the Bed-occupancy, Utilization and Turnover Rate of Acharya Vinoba Bhave Rural Hospital, India
Authors: Shahu Shivani , Shinde Vitthal , Gudhe Vandana 
Published: February 2022

Background: Hospital expenses in healthcare system are the key component of health care. For this reason, investment is the main objective of increased expenditure in healthcare sector, expertise. As a developing country, India has had in order to face many economic and political difficulties. For administrative department as well as policy makers of hospital there is a big question of improper exploitation of hospital assets. This improper utilization is mainly affected by three factors which are patients related, administration related and physician related problems. Social and financial position of patients is responsible for inappropriate utilization of beds and it is considered as patient related factor. This study aims to assess the Bed-Occupancy, Utilization and Turnover Rate, assess problems in utilization and recommend the measures to improve.
Methodology: This will be a Record based cross sectional retrospective study conducted at Acharya Vinoba Bhave Rural Hospital, Wardha. Data will be gathered from the AVBRH medical record section.
Results: Indices for Bed occupancy rate, average length of stay, Bed turnover rats will be obtained. Data will be analysed with appropriate statistical tests.
Conclusion: Causes for underutilization, low bed occupancy and turnover rate will be revealed and necessary improvement measures will be recommended.
Estimation of Correlation between Quetelet’s Index and Nottingham Prognostic Index in Patients of Carcinoma Breast: A Study Protocol
Authors: Wajpeyi Ketki , Vagha Sunita , Shukla Samarth 
Published: February 2022

Background: Carcinoma breast is the most prevalent neoplasm in women with the highest death rate associated with cancer worldwide. In Indian women, breast cancer ranks first, followed by cervical cancer, with its incidence increasing day by day. Obesity is an important modifiable causative factor of carcinoma breast, associated with a greater chance of contracting breast cancer, and with worse prognosis in women of all age groups. It exhibits a state of chronic-inflammation, adipokine-imbalance, insulin-resistance and increased oestrogen-signalling. This pro-tumorigenic environment stimulates cancer deveoplment through abnormal proliferation and survival of breast tissue. Quetelet’s Index is the most commonly used index to classify obesity, whereas the Nottingham Prognostic Index is the most widely used index for longevity assessment and prognosis of breast cancer patients. This study estimates the correlation between Quetelet’s index with Nottingham Prognostic Index.
Methods: This prospective observational study will be to be conducted in the Department of Pathology, JNMC, Wardha and AVBRH, Sawangi (Meghe), Wardha in coordination with the Department of General Surgery. Total 35 cases of Carcinoma Breast undergoing Modified Radical Mastectomy will be included in the study. Clinicopathological and anthropometric data of patients will be collected. The Quetelet’s Index and the Nottingham Prognostic Index will be determined for each patient and data will be analyzed with appropriate statistical tests to estimate the correlation between them.
Results: Statistically significant correlation is expected between Quetelet’s Index and the Nottingham Prognostic Index.
Conclusion: Conclusion will be drawn on positive/negative correlation of Quetelet’s Index with different parameters of Nottingham’s Prognostic Index.
Comparison of Hand Grip Strength among Health Care Workers and Students
Authors: Kumaran N. Adhishwar , Sugumar N. , Subramani Niraimathy Nyorai Velu , Jagadeesh B. 
Published: February 2022

Background: The information is gathered from a wide spectrum of health-care professionals, including medical students, nurses, and doctors. The study takes place at SMCH in Chennai. For students and health workers, the offered data is also utilized to compare handgrip strength between right and left handgrip. MATLAB software is used to analyze hand grip strength among health care personnel and students, and the results are far more efficient than traditional methods.
Objective: The objective of this study is to compare hand grip strength in South Indian health care workers and students under normal and sex impact situations.
Methodology: A grip strength test will almost certainly be performed if you consult an occupational or physical therapist for any problem involving weakness. A hand-held dynamometer is commonly used to assess grip strength. The patient squeezes the dynamometer three times with each hand, using all of their strength. The comparison of different types of data will be analyzed in the proposed method by using MATLAB software.
Results: This is the first study to develop models for evaluating the strength of different types of hand grips. Gender is the most important demographic variable to include when analyzing models. The comparison analysis resulting in images shows the value of each comparison. When compared to the non-dominant and left hands, the dominant and right hands demonstrated superior grip strength. Regular assessments of hand grip strength, hand anthropometric characteristics, and hand disability level are recommended as part of routine examinations in order to detect the amount of physical disability.
Conclusion: Gender is the most important demographic variable in comparison of models. Although power grip strength is common in many sports, it may not be a strong predictor of thumb push and ball of thumb strength. The students and the health care workers are classified and their hand grip strength is calculated successfully. For convenience and time savings, there are two types of hand strength.
Comparative Evaluation of Garlic (Allium sativum) Extract in Chair Side Disinfection of Gutta Percha Cones: An In vitro Study
Authors: Rangarajan Shenbagam , Srinivasan Manali Ramakrishnan , Poorni Saravanan , Duraivel D. , Nishanthine C. , Rakshagan V. 
Published: February 2022

Background: Microbial contamination of gutta percha (GP) cones can be harmful for the success of endodontic therapy. A rapid chair side disinfection is preferred to avoid secondary infection.
Aim: The purpose of this study was to compare the efficacy of 20% and 100% garlic extract with 5.25% Sodium hypochlorite (NaOCl) and 2% Glutaraldehyde in rapid disinfection of GP.
Materials and Methods: GP were immersed in prepared suspensions of Enterococcus faecalis and Staphylococcus aureus. The cones were disinfected in 5.25%NaoCl, 2% glutaraldehyde, 20% garlic extract and 100% garlic extract for 1 and 5 minutes. The cones were then transferred to sterile test tubes containing 1ml sterile saline and vortexed vigorously for 5minutes. 100µl of the saline suspension plated onto Brain heart infusion agar by spread plate method. The plates were incubated for 24-48 hours at 37˚C and the total colony forming units/ml were calculated.
Results: Statistical analysis was done using one-way ANOVA followed post hoc Tukey test. There was no statistically significant difference among 5.25% NaOCl, 100% garlic extract and 2% glutaraldehyde.
Conclusion: Within the limitations of the study, 100% garlic extract possesses superior antibacterial activity when compared with 2% glutaraldehyde and 20% garlic extract and similar effect as 5.25% NaOCl.
Pharmaceutical Standardization of Palasha Kshara (Alkali Extract of Butea monosperma Lam.) Prepared from Two Combinations
Authors: Jaiswal Meenakshi , Wanjari Anita , Rathi Bharat , Rajput Dhirajsingh S. , Khan Mujahid , Sonare Makarand , Kohale Anup , Bhake Arvind 
Published: February 2022

Introduction: Standardization in herbal pharmaceuticals is needed in order to ensure their quality and acceptability of final medicament prepared from them. There are many plants have been suggested in the compendia for Kshara (alkali extract) preparation. Acharya Bhavamishra coined the name of plant Palasha (Butea monosperma Lam.) as Kshara Shresta means the one which is best of all Kshara. Generally all parts of plant together (Panchanga) have been suggested to be used for Kshara preparation in the texts. But considering the unavailability of all parts of the Palasha throughout the year this study has been designed to standardize the Palasha Kshara prepared from two combinations.
Aim and Objectives: Pharmaceutical and analytical standardization of Palasha Kshara PK-1 and PK-2 prepared from two combinations.
PK-1 is the Palasha Kshara prepared from combination of ashes of roots, stems, leaves, flowers and fruits.
PK-2 is the Palasha Kshara prepared from combination of ashes of roots, stems and leaves.
Observation and Results: The total yield percentage of PK-1 and PK-2 were 20.757% and 4.067% respectively. Both PK-1 and PK-2 were found alkaline in nature having ph value of 10.44 and 10.47 respectively. The ICPAES study of both PK-1 and PK-2 reveals maximum amount of potassium in them (41.65% and 47.51% respectively.) Heavy metals such as arsenic, lead, mercury, and cadmium were not detected or were found to be within acceptable ranges. The XRD study reveals presence of more functional groups in PK-2 than PK-1. The observed crystallanity of PK-1 was more (87.5%) than PK-2 (84.6%).
Discussion and Conclusion: Two varieties of Palasha Kshara were made in this study using two different combinations of ashes. This was an attempt to identify the need of Kshara prepared from all five parts of Panchanga) over the Kshara prepared from three parts (roots, stems and leaves) and standardize them pharmaceutically and analytically.
Comparative Evaluation of the Stress Distribution and Transverse Displacement of the Circummaxillary Sutural System by Four Different Designs of Rapid Maxillary Expansion Appliances Using 3D Finite Element model: A Study Protocol
Authors: Lakhe Pratiksha , Jhaveri Smit , Nasre Ashish 
Published: February 2022

Background: In adolescent patient’s Rapid maxillary skeletal expansion (RME) is used with predictable clinical results for correcting transverse maxillary skeletal contraction. During RME, heavy force is directed towards the maxillary skeletal base. These forces also have effect on the palatal bone, adjacent skeletal structures and dentition. Tooth supported RME apply significant pressure on the teeth leading to varying amount of buccal inclination of premolars and molars and dental expansion. Implant assisted expanders take skeletal anchorage thus minimizing or negating the effect of heavy pressure on the teeth and supporting structures. Finite Element Analysis is a form of computer simulation. It is a non-invasive, precise method for obtaining quantitative and comprehensive knowledge about the physiological responses that occur in tissues. It outperforms other experimental methods because it creates a three-dimensional model that allows for simulation and analysis of orthodontic force systems in all three dimensions.
Objective: The present study intends to make an assessment of four different RME designs (Banded HYRAX, Banded MARPE, MSE expander, Orthoeasy PAL expander) in terms of distribution of stress in the circummaxillary Sutural system and resulting displacement of the bones in the craniofacial complex upon activation of the respective appliance.
Methodology: CBCT scan data of an adolescent patient will be taken from archives of a reputed scan centre. 3D skull model will be generated using CBCT data and .stl/ DICOM format will be converted into Finite Element model. The different types of RME appliances will be designed over the FE model. The expanders will be activated and the stresses generated at the sites of interest would be studied.
Results: The study is expected to permit a clinician to select the design of RME appliances, which will produce suitable stress and displacement that will help to increase transverse width of maxilla to correct the underlying skeletal discrepancy.
Conclusion: This study will help to arrive at a conclusion about which designs of RME will best suit clinical application of mechanics for orthopaedic expansion in a particular case.
Mother’s Knowledge on Neonatal Danger Signs and Health Seeking Behaviour in a Tertiary Care Hospital, Thandalam, India
Authors: Prageetha K. , Kumutha . 
Published: February 2022

Objective: The aim of this study is to find out mother’s knowledge on neonatal danger signs and health seeking behaviour in a tertiary care hospital.
Methods: A cross sectional descriptive study was conducted among mother’s of infant(below 1 year) attending Department of Paediatrics and Department of Obstetrics and Gynaecology, Saveetha Medical College, Thandalam between January 2021 to April 2021. A semi structured questionnaire was used in this study. The data were entered in Microsoft Excel. The chi square values were determined, P<0.05 was considered significant.
Results: Among the 273 respondents,102(37.36%)of mothers were found to have good knowledge on neonatal dangersigns.161 mothers had sick neonate who need medical attention. Of the 161, 146 (90.68%) mothers sought health facility for help and had their baby treated. Factors that were significantly associated with mother’s knowledge on neonatal danger signs were mother’s educational status and occupation, income, husband’s involvement in antenatal and reproductive service, information on neonatal danger signs given after delivery. Significant associated factors for safe health seeking behaviour were mother’s educational status, AN check up, PNC follow up, husband’s involvement, good knowledge on neonatal danger signs.
Conclusion: The study shows that 37.36% of mothers had good knowledge on neonatal danger signs and 90.68% had safe health seeking behaviour. Despite the low knowledge on neonatal danger signs, mother’s health seeking behaviour was better (90.68%) which might be due to their good antenatal check up, postnatal follow up.
Short-term Effect of Mirror Therapy and Mobilization in Adhesive Capsulitis: A Randomized Controlled Trial
Authors: Jagadeesh Rajkrishnan , Srivastava Saumya 
Published: February 2022

Background: Frozen Shoulder, also known as Adhesive Capsulitis is the developing of dense adhesions, joint capsule thickening and capsular restrictions in the joint along with diminished glenoid cavity. Primary adhesive capsulitis most commonly affects individuals between 40 to 60 years of age. A number of treatment techniques exists for the improvement of adhesive capsulitis whereas Mirror Therapy is a recent technique designed to improve adhesive capsulitis.
Objective: To compare the short-term effect of Mirror Therapy and Maitland Mobilization in stage 1 & 2 adhesive capsulitis.
Methodology: The study is a randomized controlled trial which included 34 subjects of the age group 40-60, and were randomly assigned into two groups: Group A (n=17) and Group B (n=17). The Group A was given Mirror Therapy with conventional physical therapy while group B was given Maitland Mobilization with conventional physical therapy. Outcome measure were taken at baseline, and then taken on last day of seventh session by using VAS, ROM, DASH. The treatment was given for 7 sessions over a period of two weeks.
Results: The results show that on comparison of pre and post intervention values within each group, both the groups produced statistically significant difference (p<0.05). On comparison between the groups, ROM shows statistically significant difference(p<0.05) compared to VAS and DASH.
Conclusion: The current study results shows that Mirror Therapy is better than Maitland Mobilization in terms of relieving pain, improving functional activity and increasing range of motion.
Clinical Trials Registration No. CTRI/2020/09/027576.