bluuebunny/crossref_metadata_2025_split huggingface dataset:
KẾT QUẢ HÓA TRỊ PHÁC ĐỒ PACLITAXEL VÀ CARBOPLATIN TRÊN BỆNH NHÂN UNG THƯC THỰC QUẢN GIAI ĐOẠN IV TẠI BỆNH VIỆN K
Authors: Thu Trang Nguyễn , Anh Tú Đỗ 
Published: September 2022

Mục tiêu: Đánh giá kết quả hóa trị phác đồ paclitaxel và carboplatin trên bệnh nhân ung thư thực quản giai đoạn IV tại bệnh viện K. Đối tượng và phương pháp: Nghiên cứu mô tả hồi cứu và tiến cứu được thực hiện trên 48 người bệnh ung thư thực quản giai đoạn IV trong thời gian từ tháng 8 năm 2021 đến tháng 8 năm 2022. Kết quả: Tỷ lệ bệnh nhân đáp ứng với điều trị ở chu kỳ 3 là 43,8% (đáp ứng một phần là 37,5% và đáp ứng toàn bộ là 6,3%). Tỷ lệ người bệnh đáp ứng điều trị ở chu kỳ 6 là 52,1% (đáp ứng một phần là 43,8% và đáp ứng toàn bộ là 8,3%). Các triệu chứng phổ biến nuốt nghẹn, đau khi nuốt, sặc được cải thiện qua các thời điểm điều trị. Các tác dụng không mong muốn gồm buồn nôn, nôn, viêm miệng, tiêu chảy, rụng tóc có xu hướng giảm dần qua các chu kỳ điều trị. Tác dụng phụ trên huyết học có tỷ lệ thấp và kiểm soát được. Kết luận: Phác đồ điều trị này có thể được áp dụng phổ biến hơn trong điều trị ung thư thực quản do an toàn và dung nạp tốt
rs10737680 polymorphism in complement factor H and neovascular age-related macular degeneration in Yogyakarta, Indonesia
Authors: Sigalingging Talenta , Perdamaian Ayudha Bahana Ilham , Romdhoniyyah Dewi Fathin , Prayogo Muhammad Eko , Wardhana Firman Setya , Widayanti Tri Wahyu , Sasongko Muhammad Bayu , Agni Angela Nurini , Oka Chio , Supanji Supanji 
Published: September 2022

Background: Neovascular age-related macular degeneration (nAMD) is one of the main causes of blindness in developed countries. Complement factor H (CFH) is one of the genes involved in the pathogenesis of nAMD. This study investigated the rs10737680 polymorphism in CFH and its conferred susceptibility to nAMD in Yogyakarta, Indonesia.
Methods: This case-control hospital-based study recruited participants consisting of 96 patients with nAMD and 101 controls without nAMD from the Eye Polyclinic of Sardjito Hospital, YAP Eye Hospital, and Hardjolukito Hospital Yogyakarta. nAMD was diagnosed when fundus examination, fundus photographs, and optical coherence tomography revealed hard or soft drusen in the macular area measuring > 63 µm that appeared below the retinal pigment epithelium, with or without macular hypo- or hyperpigmentation, and was accompanied by choroidal neovascularization. Genomic DNA was extracted using a commercial DNA isolation kit. The restriction fragment length polymorphism technique was used to identify the rs10737680 polymorphism in CFH.
Results: The mean (standard deviation [SD]) age of the nAMD group was not homogeneous with that of the control group (P < 0.05); 65.41 (9.74) years versus 68.24 (7.82) years. The number of patients with hypertension in the nAMD group was significantly higher than in the control group (P < 0.05). In the nAMD group, the genotype distribution indicated homozygous risk allele in 34.38%, heterozygous risk allele in 57.29%, and homozygous non-risk allele in 8.33%. In the control group, the genotype distribution indicated homozygous risk allele in 21.78%, heterozygous risk allele in 36.63%, and homozygous non-risk allele in 41.58%. Statistical analysis between the two study groups according to homozygous risk allele genotype (odds ratio [OR], 7.87; 95% confidence interval [CI], 2.88–22.79) and heterozygous genotype (OR, 7.80; 95% CI, 3.11–21.19) showed a significant difference (both P < 0.01).
Conclusions: Homozygous risk allele was less frequent than heterogeneous risk allele in patients with nAMD; however, both increased the risk for nAMD. Although the homozygous or heterozygous risk-alleles were detected in most patients, yet other important genetic or environmental factors could be involved in the pathogenesis of nAMD. Overall, we found a significant association between rs10737680 polymorphism in CFH and the susceptibility to nAMD in Yogyakarta, Indonesia; however, future studies are needed to fully delineate the mechanism.
FAKTOR YANG BERHUBUNGAN DENGAN TERJADINYA PERNIKAHAN USIA DINI DI DESA BANDAR TARUTUNG KECAMATAN SANGKUNUR KABUPATEN TAPANULI SELATAN TAHUN 2020
Authors: Heriansyah Rizka 
Published: September 2022

Pernikahan usia anak atau lebih dikenal dengan istilah pernikahan di bawah umur merupakan salah satu fenomena sosial yang banyak terjadi diberbagai tempat di tanah air, baik di perkotaan maupun di perdesaan. Tujuan penelitian ini adalah untuk menganalisis faktor yang berhubungan dengan terjadinya pernikahan usia dini di Desa Bandar Tarutung Kecamatan Sangkunur Kabupaten Tapanuli Selatan. Metode penelitian adalah kuantitatif dengan desain penelitian cross sectional study. Penelitian dilakukan di Desa Bandar terhadap, 170 yaitu remaja putri (15-19 tahun) dengan sampel 63 remaja putri. Analisa data yang digunakan adalah Chi Square. Hasil penelitian menunjukkan adanya hubungan umur dimana nilai p value 0,026, pendidikan dimana nilai p value 0,017 penghasilan orangtua dimana nilai p value 0,033, keadaan sebelum menikah dengan pernikahan usia dini, dimana nilai p value 0,036, kebiasaan/ kepercayaan tentang pernikahan dengan pernikahan dini, dimana nilai p value 0,020 pengetahuan dimana nilai p value 0,030 dengan pernikahan usia dini. Hasil penelitian ini merekomendasikan pemerintah agar merevisi UU No. 1 Tahun 1974, usia pernikahan minimal pria adalah 19 tahun dan perempuan adalah 16 tahun. Menjadi usia ideal pernikahan menurut DP3APPKB adalah 25 tahun untuk pria dan 21 tahun untuk perempuan.
A scholarly and research analysis of “Al Aam” and its allocation by custom
Authors: Muhammad Qanit Dr. Fakharuddin Syed , Ali Dr. Ishfaque , Sohail Dr. Muhammad 
Published: September 2022

common knowledge is the acquistion of fiqqa from important topics because because these topics are related from quran and the its accuracy is determined from quran and the sayings of holy prophet pbuhqiyaas,masaalh,marsala,aarf and hajjaj are related to it are verified throughout (aam) is that word which is used for many people words like muslimeen and nisaa are used for it,there are two types of (aam) first type refers to that condition in which all the people are included and no one can be excluded from it and in this condition the word aam is dominant on its meaning.in this condition the saying is that it is compulsory on every one. the second condition is that aarf according to shariat is liable and it has two types first is aarfqooliaarfqooli is that which is transfered to people through practice and preaching the second type is aarffaali this type comes in that condition which is not against the majority. aarffassida is another type is that condition in which haram is concerted to halal and halal is converted to haram.
Analytical Study of the Concept of the Historiography of Molana Shibli Nomani (A Historical Analysis)
Authors: Rahman Shafiq-ul- , Rasheed Zukhraf , Akhtar Dr. Sohail 
Published: September 2022

Shibli is considered one of the important Muslims Historian, during the decline period when the Muslim has lost their glory and dignity in colonial India. They last their political identity with their powers in this situation Shibali born at Delhi. Maulana Shibli Nomani has most eminent and important position in the historiography among the entire historian of India who wrote history in indigenous language during 19th century. Shibli born in 1858 and he received is early education from different institutions. After receiving his traditional Muslim education from different renowned scholar of the time. Later on Shibli finally entered in the circle of Sir Syed Ahmed Khan. Shibli looked the position of Muslims and tried to boost up them again according to the glorious period of Past. That’s why Shibli worked on the remarkable personalities and wrote biographies i.e. Seerat-ul-Nabi, Al-Farooq and Al-Mammon etc.
Significance of Prisons in the light of Islamic Teachings
Authors: Ullah Amman , Ahmad Prof: Dr. Matloob 
Published: September 2022

Jail means the place in which the accused persons are kept for investigation or criminals are kept for punishment. In jail, prisoners lose their right of freedom. The aim to establish jail is to frighten the unseemliness people, betterment of unconscious and ignorant persons and to give punishment to the criminals, so that peace of society may be maintained. The regular system of jail was not present in the period of Holy Prophet (ﷺ) and caliph Hazrat Abu Bakar (R.A), but the concept of imprisonment existed. Hazrat Umer (R.A) Bought the house from Safwan bin Umayyah and used it as a jail in his reign. That was also present in the reign of Hazrat Usman (R.A). When Hazrat Ali (R.A) Became caliph, he constructed first regular jail which was given the name “Nafay”. The Second jail was “Mukhaius”. In Short, the concept of jail is taken from the Holy Quran, Hadith, remains of Sahaba and consensus of the Ummah.
Fauna ictioparasitária em tambaqui (Colossoma macropomum) na Amazônia Brasileira – uma revisão
Authors: Mirele Alves Barros David , Vieira da Silva Maxsiele , Maia Carvalho Clarice 
Published: September 2022

O tambaqui é a segunda espécie mais produzida no Brasil. A ocorrência de doenças através das infecções parasitárias pode inviabilizar o sucesso da piscicultura. Nesse contexto, o presente estudo teve como objetivo realizar uma revisão sistemática de trabalhos publicados de 2000 a 2021 sobre parasitas em tambaqui (Colossoma macropomum) em piscicultura na Amazônia Brasileira. Como estratégia metodológica foi realizada uma busca sistemática nas plataformas Google Acadêmico, Scielo, PUBMED, BVS. Foram utilizados os descritores Colossoma macropomum, tambaqui, parasite Colossoma macropomum, parasitas em tambaqui. Foram encontrados 35.980 artigos no Google Acadêmico, 302 no Scielo, 389 no PUBMED, e 763 BVS sendo selecionados 21 artigos. Os estados do Pará (36,1%) e Amazonas (26,2%) são os que possuem maior quantidade de trabalhos científicos sobre a ictiofauna do tambaqui em piscicultura. Em relação a presença de parasitos, foram relatadas 36 espécies, sendo a mais frequente A. spathulatus, encontrados nos estados do Amapá, Amazonas, Pará e Rondônia. Os órgãos mais afetados por parasitas foram as brânquias (31,4%), seguido de intestino (11,8%).
Verificação das boas práticas de fabricação em unidades produtoras de refeições de Bacabal - MA
Authors: Silva da Rocha Thaís , Mesquita Matheus de Sousa Silva 
Published: September 2022

As mudanças nos hábitos alimentares da população mundial propiciaram a expansão e popularização do mercado de refeições fora lar, nesse contexto as unidades produtoras de refeições ou UPR's devem garantir a inocuidade das refeições aos seus consumidores, uma vez que estas são muito susceptíveis à contaminação, sobretudo de ordem microbiana. A garantia de inocuidade se dá através da adoção das Boas Práticas preconizadas pelas RDC nº 275 e RDC nº 216. A pesquisa realizou-se durante o mês de outubros de 2021 em cinco estabelecimentos de pequeno porte escolhidos aleatoriamente (A, B, C e D, respectivamente) durante os horários de pico onde houve a aplicação do checklist da RDC nº 275 para verificar o cumprimento das Boas práticas de Fabricação. Após o tratamento dos dados constatou-se que todas as UPR’s avaliadas nesse estudo se enquadraram no Grupo II, portanto obtiveram classificação Regular (Tabela 1). Conclui-se que apesar das limitações do ambiente de trabalho e falta de capacitação adequada as UPR's mantiveram um certo grau de higiene porem as inadequações representam um perigo aos consumidores.
FREQUENCY OF IRON DEFICIENCY ANEMIA IN NON-DIALYSIS CHRONIC KIDNEY PATIENTS
Authors: Khan Merina , Mahmood Syed Nayyer , Fatima Novara 
Published: September 2022

Background: Iron deficiency anemia (IDA) is the most common type of anemia. In chronic kidney disease (CKD) patients, it’s a significant burden and becomes more prevalent with decreasing GFR. Though, erythropoietin deficiency remains the major cause of anemia in CKD patients due to decreased renal erythropoietin production, yet the frequency of IDA in pre-dialysis CKD patients has not been well established in Pakistan.
Objective: To determine the frequency of IDA in pre-dialysis CKD patients.
Materials and Methods: 188 pre-dialysis CKD patients of age 18-75 and both genders were included. Patients having obvious causes of anemia were excluded. The percentage of patients with IDA in pre-dialysis CKD was then determined during OPD follow up.
Results: Mean age was 46.03±12.24 years. Out of 188 patients, 102 (54.26%) were males with male-female ratio of 1.2:1. The frequency of IDA in pre-dialysis CKD patients was found in 73 (38.83%) patients.
Conclusion: Study concluded that frequency of IDA in pre-dialysis CKD patients is high and close attention to the causes and its replacement may improve the patient outcome.
Keywords: CKD, Pre-dialysis , IDA, anemia
Hubungan Gaya Hidup dengan Kejadian Hipertensi di wilayah Kerja Puskesmas Martapura 2
Authors: Raziansyah Raziansyah , Ridha Amalia Nor 
Published: September 2022

Pendahuluan : Gaya hidup tidak sehat dapat menyebabkan terjadinya berbagai penyakit, salah satunya yaitu hipertensi. Tujuan penelitian ini yaitu mengetahui hubungan gaya hidup dengan kejadian hipertensi di wilayah kerja puskesmas Martapura 2.
Metode : Penelitian ini menggunakan pendekatan deskriptif korelasi dengan populasi adalah seluruh penderita hipertensi berjumlah 613 orang. Teknik pengambilan sampel yang digunakan Probability Sampling dengan jumlah sampel 86 orang, dan menggunakan analisis Sperman-Rank.
Hasil : Penelitian menunjukkan bahwa gaya hidup penderita hipertensi mayoritas adalah berkategori baik sebanyak 60 orang (69,8%), sedangkan yang paling sedikit yaitu berkategori buruk sebanyak 26 orang (30,2%). Kejadian hipertensi mayoritas adalah berkategori ringan sebanyak 47 orang (54,7%), sedangkan yang paling sedikit yaitu berkategori berat sebanyak 17 orang (19,8%). Hasil menunjukkan Adanya hubungan gaya hidup dengan kejadian hipertensi dengan nilai p-value=0,000 (α < 0,005).
Kesimpulan : Disarankan penderita hipertensi dapat meningkat gaya hidup kearah yang lebih baik seperti aktifitas fisik dengan berolah raga, membatasi makanan yang berlemak dan makanan asin serta menghindari kebiasaan merokok sehingga tekanan darah dapat terkontrol.
Patient Comorbidities Associated With Acute Infection After Open Tibial Fractures
Authors: Saiz Augustine M. , Stwalley Dustin , Wolinsky Philip , Miller Anna N. 
Published: September 2022

Introduction:
Open tibial shaft fractures are high-risk injuries for developing acute infection. Prior research has focused on injury characteristics and treatment options associated with acute inpatient infection in these injuries without primary analysis of host factors. The purpose of this study was to determine the patient comorbidities associated with increased risk of acute infection after open tibial shaft fractures during initial hospitalization.

Methods:
A total of 147,535 open tibial shaft fractures in the National Trauma Data Bank from 2007 to 2015 were identified that underwent débridement and stabilization. Infection was defined as a superficial surgical site infection or deep infection that required subsequent treatment. The International Classification of Diseases, ninth revision codes were used to determine patient comorbidities. Comparative statistical analyses including odds ratios (ORs) for patient groups who did develop infection and those who did not were conducted for each comorbidity.

Results:
The rate of acute inpatient infection was 0.27% with 396 patients developing infection during hospital management of an open tibial shaft fracture. Alcohol use (OR, 2.26, 95% confidence interval [CI], 1.73-2.96, P < 0.0001), bleeding disorders (OR, 4.50, 95% CI, 3.13-6.48, P < 0.0001), congestive heart failure (OR, 3.25, 95% CI, 1.97-5.38, P < 0.0001), diabetes (OR, 1.73, 95% CI, 1.29-2.32, P = 0.0002), psychiatric illness (OR, 2.17, 95% CI, 1.30-3.63, P < 0.0001), hypertension (OR, 1.56, 95% CI, 1.23-1.95, P < 0.0001), obesity (OR, 3.05, 95% CI, 2.33-3.99, P < 0.0001), and chronic obstructive pulmonary disease (OR, 2.09, 95% CI, 1.51-2.91, P < 0.0001) were all associated with increased infection rates. Smoking (OR, 0.957, 95% CI, 0.728-1.26, P = 0.722) and drug use (OR, 1.11, 95% CI, 0.579-2.11, P = 0.7607) were not associated with any difference in infection rates.

Discussion:
Patients with open tibial shaft fractures who have congestive heart failure, bleeding disorders, or obesity are three to 4.5 times more likely to develop an acute inpatient infection than patients without those comorbidities during their initial hospitalization. Patients with diabetes, psychiatric illness, hypertension, or chronic obstructive pulmonary disease are 1.5 to 2 times more likely to develop subsequent infection compared with patients without those comorbidities. Patients with these comorbidities should be counseled about the increased risks. Furthermore, risk models for the infectious complications after open tibial shaft fractures can be developed to account for this more at-risk patient population to serve as modifiers when evaluating surgeon/hospital performance.

Conclusion:
Patient comorbidities are associated with increased risk of acute inpatient infection of open tibial shaft fractures during hospitalization.
TĂNG CƯỜNG HOẠT ĐỘNG TRẢI NGHIỆM KHI DẠY HỌC BIỂU ĐỒ TRANH CHO HỌC SINH LỚP 2
Authors: Thuận Trần Đức , Trân Văn Quế , Yến Nguyễn Hoàng Kim , Đan Nguyễn Ngọc 
Published: September 2022

Trong Chương trình Giáo dục phổ thông môn Toán năm 2018, biểu đồ tranh nói riêng và một số yếu tố thống kê, xác suất nói chung là những nội dung phù hợp để tổ chức các hoạt động trải nghiệm và thực hành. Dựa trên chu trình học tập trải nghiệm đề xuất bởi Kolb và kết quả nghiên cứu về các yếu tố thống kê, xác suất trong giáo dục Toán học cấp tiểu học, một kịch bản dạy học biểu đồ tranh đã được xây dựng. Trong kịch bản dạy học này, học sinh lớp 2 được khuyến khích tham gia những hoạt động trải nghiệm như điều tra, thu thập, phân loại, ghi chép, sắp xếp, biểu diễn, phân tích các số liệu thống kê. Kết quả thực nghiệm cho thấy, việc khai thác kinh nghiệm cá nhân và các hoạt động trải nghiệm có thể giúp tăng hiệu quả dạy học biểu đồ tranh nói riêng và các yếu tố thống kê, xác suất nói chung.
EFEKTIFITAS TRICHODERMA INDIGENUS SULAWESI TENGGARA SEBAGAI BIOFUNGISIDA TERHADAP Colletotrichum sp. SECARA IN- VITRO
Authors: GUSNAWATY HS , TAUFIK MUHAMMAD , HERMAN HERMAN 
Published: September 2022

This research aimed to determine the effectivity of Trichoderm isolates indigenous of Southeast Sulawesi as biofungicide to Colletotrichum sp in- vitro. This research was carried out in the Laboratory of Agrotechnology, Plant Pathology unit, Faculty of Agriculture, Halu Oleo University. Inhibition effectivity of 11 Trichoderma spp. isolates was done in double PDA media. This research used the complete randomized design (CRD). The observed variables were the inhibitory of Trichoderma spp. indigenous on the growth of Colletotrichum sp. Research result showed that the 11 isolates were effective as biofungicide against Colletotrichum sp. The data analysis showed that isolates DPA was the best isolate, inhibiting Colletotrichum sp. by 77.69%, otherwise LKP was isolate with the lowest inhibitory ability against Colletotrichum sp, by 65.07%. Inhibition mechanism of isolates DPA and DKT against Colletotrichum sp was by area competition and parasitism.Key words: Antagonist, Colletotrichum sp., Trichoderma Indigenous.
Investment, power and protein in sub-Saharan Africa
Authors: Brice Jeremy 
Published: September 2022

The place of protein in sub-Saharan Africa’s food system is changing rapidly, raising complex international development, global health and environmental sustainability issues. Despite substantial growth in the region’s livestock agriculture sector, protein consumption per capita remains low, and high levels of undernourishment persist. Meanwhile sub-Saharan Africa’s population is growing and urbanising rapidly, creating expectations that demand for protein will increase rapidly over the coming decades and triggering calls for further investment in the expansion and intensification of the region’s meat and dairy sector. However, growing disquiet over the environmental impacts of further expansion in livestock numbers, and growing sales of alternative protein products in the Global North, has raised questions about the future place of plant-based, insect and lab-grown proteins in African diets and food systems. This report examines financial investment in protein production in sub-Saharan Africa. It begins from the position that investors play an important role in shaping the development of diets and food systems because they are able to mobilise the financial resources required to develop new protein products, infrastructures and value chains, or to prevent their development by withholding investment. It therefore investigates which actors are financing the production in sub-Saharan Africa of: a) animal proteins such as meat, fish, eggs and dairy products; b) ‘protein crops’ such as beans, pulses and legumes; and c) processed ‘alternative proteins’ derived from plants, insects, microbes or animal cells grown in a tissue culture. Through analysing investment by state, philanthropic and private sector organisations – as well as multilateral financial institutions such as development banks – it aims to establish which protein sources and stages of the value chain are financed by different groups of investors and to explore the values and goals which shape their investment decisions. To this end, the report examines four questions: 1.	Who is currently investing in protein production in sub-Saharan Africa? 2.	What goals do these investors aim to achieve (or what sort of future do they seek to bring about) through making these investments? 3.	Which protein sources and protein production systems do they finance? 4.	What theory of change links their investment strategy to these goals? In addressing these questions, this report explores what sorts of protein production and provisioning systems different investor groups might be helping to bring into being in sub-Saharan Africa. It also considers what alternative possibilities might be marginalised due to a lack of investment. It thus seeks to understand whose priorities, preferences and visions for the future of food might be informing the changing place of protein in the region’s diets, economies and food systems.
Peningkatan Penggunaan Komunikasi Pemasaran yang efektif bagi Usaha Kecil (Triple 3 Music Bandung)
Authors: Handayani Trustorini 
Published: September 2022

Triple 3 Music adalah bisnis mikro yang dimiliki oleh generasi milenial yang kegiatannya melakukan penjualan Alat-alat musik dan pad cast serta peralatan-peralatan yang mendukung kegiatan masyarakat yang dilakukan secara Daring. Dengan kondisi pandemic, untuk memenuhi kebutuhan masyarakat akan barang-barang yang berkaitan dengan kegiatan Daring, diperlukan penjualan secara online. Untuk memenuhi peluang yang ada tentu diperlukan komunikasi pemasaran yang efektif secara online dalam memperkenalkan produk yang di jual ke pada masyarakat pengguna atau konsumen. Tujuan Pengabdian, untuk mengkaji Komunikasi pemasaran secara online yang sudah dilakukan oleh Mitra saat ini dan bagaimana dapat menggunakan e-commerce secara efektif.Metode pelaksanaan pengabdian dengan studi Pustaka, menentukan lokasi, waktu, sosialisasi, diskusi, pelatihan dan Partisipasi Mitra, penyusunan laporan dan publikasi. Hasil pengabdian ini diharapkan Mitra dapat melakukan Teknik penjualan, menerima keluhan konsumen secara online, sehingga dapat meningkatkan penjualan dan laba.