bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mariátegui’s Thought in the Peasant Struggles of Hugo Blanco
Authors: Pensado Leglise Patricia , Camacho Olvera Nayeli 
Published: June 2022

The peasant uprisings in the valleys of La Convención and Lares in Cuzco, Peru, in the late 1950s and early 1960s placed the Peruvian indigenous peasantry at the center of the national scene and led to the 1969 agrarian reform that would transform the property-labor system in the Peruvian countryside (a system that produced the famous Mariátegui aphorism “The problem of the Indian is the problem of land”). Hugo Blanco Galdós was an iconic figure and one of the leaders of this movement. Although Trotskyism was the most visible directive of his political praxis during his militancy in La Convención, the influence of José Carlos Mariátegui’s (1894–1930) thought was what marked it. While the twenty-first-century indigenous peasant struggles have modified their objectives and discourse, Mariátegui’s thought remains current in a figure such as Blanco. Los levantamientos campesinos en los valles de La Convención y Lares en Cuzco, Perú, a finales de la década de 1950 y principios de la década de 1960 pusieron al campesinado indígena peruano al centro de la escena nacional y condujeron a la reforma agraria de 1969, la cual transformaría el sistema de propiedad-trabajo en el campo peruano (sistema que dio lugar al famoso aforismo de José Carlos Mariátegui, “El problema del indio es el problema de la tierra”). Hugo Blanco Galdós fue una figura icónica y uno de los líderes de este movimiento. Aunque el trotskismo fue la directriz más visible de su praxis política durante su militancia en La Convención, la influencia del pensamiento de Mariátegui (1894–1930) fue lo que la marcó. Si bien las luchas campesinas indígenas del siglo XXI han modificado sus objetivos y discurso, el pensamiento de Mariátegui sigue vigente en una figura como Blanco.
Academic Outcomes Among Children Who Experienced or Were Exposed to Physical Abuse
Authors: Renner Lynette M. , Piescher Kristine N. , Mickelson Nicole L. 
Published: June 2022

All forms of family violence may negatively affect a child’s development. However, research on child maltreatment is primarily focused on the child who is directly maltreated and does not often account for how other children in the family experience the abuse. The central aim of our study was to better understand how children’s direct experience of physical abuse and exposure to physical abuse influence their academic outcomes. Data were taken from the Minnesota Departments of Education and Human Services. The sample was developed from a population-level cohort of 8–10 years old children ( N = 1740) from two groups: Child Protective Service (CPS)-involved (a child who allegedly experienced physical abuse or a child who was exposed to the alleged physical abuse of another child in their household) and the matched comparison. Exposure to intimate partner violence (IPV) was also measured for CPS-involved children. School attendance and academic achievement were examined over 4 years. Descriptive statistics and Generalized Estimating Equations (GEE) were used to answer the three research questions. Over time, declines in attendance for children exposed to physical abuse were significantly greater than those of their matched peers. Exposure to IPV for CPS-involved children resulted in further declines in attendance. Math proficiency of children who experienced physical abuse declined at a significantly faster rate than their matched peers. The decline in reading proficiency of both children who experienced physical abuse and children exposed to physical abuse was more significantly pronounced than that of their matched peers. Differences in math and reading proficiency were eliminated when IPV exposure was taken into account. Child protection workers and school professionals should be aware of negative effects of experiences of and exposures to child maltreatment and work collaboratively to provide academic support, counseling, and other interventions to support children’s academic stability.
Epoxy-based composites with enhanced thermal properties through collective effect of different particle size fillers
Authors: Zeng Xiaoyang , Zhang Zhengguo , Pan Yaoqi , Zhang Yongle , Hou Linxi 
Published: June 2022

Taking advantages of excellent adhesion and insulating properties, polymer-based thermal interface materials have been widely used in electrical and electronic industry. However, applications was limited due to the existence of high interfacial resistance and poor mechanical properties resulted from poor dispersion and weak interfacial adhesion of thermal conductive fillers in the polymer matrix. Herein, different sizes of aluminum oxide microparticle was used as thermal conductive fillers to fabricate a series of high thermal conductive epoxy composites, and the effect of fillers loading ratio on the properties of thermal conductive, mechanical, thermal stability was further analyzed. The optimum composite exhibits a high thermal conductivity (1.91 ± 0.02 W·m−1·K−1) at a loading ratio of 1: 2 (20-μm: 70-μm, mass ratio), which is equivalent to a thermal conductivity enhancement of 950% in comparison with pure epoxy resin. The outstanding properties of the as-prepared composite is mainly attributed to the effective conductive network formed by different size fillers that the smaller particles act as a bridge to connect the larger one. This work has proved by Agari model that combining different sizes Al2O3 as fillers is a workable way to obtain composite with high thermal conductivity and it is expected to provide a reliable route for the preparation of thermally conductive composites with different particle sizes.
A study on the dynamic characteristics of the new type of prefabricated slab ballastless track structure for urban rail transit applications
Authors: Ye Mengxuan , Zeng Zhiping , Zeng Hualiang , Ruan Qingwu , Huang Zhibin , Shuaibu Abdulmumin Ahmed 
Published: June 2022

In order to solve the thorny problem of maintenance and repair of cast-in-place monolithic track slab, a new type of prefabricated slab ballastless track structure is developed for ordinary sections and damping sections. This study uses dynamics software to establish a vehicle-ballastless track coupling dynamics model, to explore the dynamic properties of the new type of prefabricated ballastless track structure in ordinary and damping sections. The model is verified using field measurement to prove its reliability. Based on the results obtained in the study, the following conclusions are deduced: (1) The vertical displacement of the floating slab in the damping section is increased by 82.95 times compared with the ordinary section. However, the vertical acceleration of the tunnel wall is reduced by 90.48%, while the insertion loss of vertical vibration acceleration of the tunnel wall is 11.08 dB, which meets the requirements of the code (CJJ/T 191-2012). (2) As the stiffness of the damping cushion increases, the vertical displacements of the rail and track slab are reduced by 43.25% and 56.68%, respectively, while the insertion loss of the vertical vibration acceleration is reduced by 31.28%. (3) As the damping increases, the vertical acceleration of the tunnel wall increases by 75.96%, whereas the insertion loss of the vertical vibration decreases by 30.51%. When the damping or the stiffness of rubber cushion is greater than 0.132 MN·s/m3 or 0.0231 N/mm3, the damping does not meet requirements. (4) When the thickness of the floating slab is increased from 200 mm to 350 mm, the vertical accelerations of the floating slab and the tunnel wall are reduced by 35.79% and 41.35%, respectively, whereas the insertion loss of the vertical vibration acceleration is increased by 37.36%.
Autism as a difference or a disorder? Exploring the views of individuals who use peer-led online support groups for autistic partners
Authors: Lewis Laura Foran 
Published: June 2022

Approximately one-third of autistics report intimate relationship experience, but few studies have explored neuromixed relationships from the perspectives of non-autistic partners. Non-autistic partners increasingly use peer-led online groups to seek support. The purpose of this study was to capture a theory that reflects the basic social experience of individuals who use these support groups using classic Glaserian grounded theory methodology. Online interviews were conducted with 162 non-autistics who believed that they were in neuromixed relationships. Data were concurrently collected and analyzed using constant comparative analysis. Participants described varying views of autism, from a difference to a disorder, which defined the context of their relationships. Five relationship profiles emerged—mutual partnership: viewed partners as = companionship: viewed partners as friends but lacked a deeper connection; caregiving: viewed partners as dependents and compared relationships to parent–child dyads; detachment: viewed relationships as broken beyond repair and isolated selves from partners; and discriminatory: believed and circulated negative generalizations about autism. Many participants who were dissatisfied in their relationships shared that their partners were not formally evaluated and did not self-identify as autistic. Future research should explore ways that autism labels are (mis)applied by the general public based on negative stereotypes about autism. Lay abstract Individuals who use peer-led online support groups for partners of autistics describe diverse views of autism, with some describing autism as a difference and others describing it as a disorder. I conducted online interviews with 162 non-autistics who believed they were in relationships with autistics and who participated in online support groups on social media. I analyzed their responses by constantly comparing each interview to previous interviews to develop a theory about their social experiences. As many as one-third of autistics participate in romantic relationships, and many of their partners seek support through groups on social media. Few studies explore what it is like to be a non-autistic person who is in a relationship with an autistic person. The way that participants viewed autism influenced the way that they viewed themselves, their partners, and their relationships. Many participants who were dissatisfied in their relationships shared that they believed their partners were autistic, but their partners had never been formally evaluated and did not self-identify as autistic. Future research should explore ways that autism labels are (mis)applied by the general public based on negative stereotypes about autism.
Utility of 4D CT in endoleak characterization after advanced endovascular aortic repair
Authors: Tarulli Massimo , Tan Kong Teng , Lindsay Thomas , Mahmood Daniyal Nasir , Santiago Sam , Jaberi Arash , Mafeld Sebastian 
Published: June 2022

Objectives To assess the performance of dynamic or 4D CT in characterizing endoleaks in advanced endovascular aortic repair (branched and fenestrated) when other modalities fail to fully characterize the leak, most often conventional CTA. Methods Retrospective review of 13 patients from 2008 to 2021 who underwent 16 4D CTs to characterize endoleaks in branched and fenestrated endovascular aortic repair (FB-EVAR). The 4D CTs were performed covering up to 16 cm of the z-axis, with anywhere between 10 and 40 iterations performed every 2 s. These settings were adjusted depending on graft characteristics and type of endoleak suspected. The scans were assessed for their ability to detect the endoleak (sensitivity), and further to characterize the endoleak by type and subtype (specificity). Results Overall sensitivity in 16 scans for endoleak detection was 100%. There was a specificity of 87.5% for determining the type of endoleak (14/16). These results included two studies that were inconclusive and repeated due to technical difficulties. In patients where a specific subtype was not established, the leak was localized to the appropriate target vessel. Average dose for the 4D CT was 4724 mGy*cm (1108–11069), with the outlining higher dose scans secondary to higher iterations in those scans. Conclusions 4D CT is a useful adjunctive tool in FB-EVAR surveillance with excellent sensitivity and specificity in characterizing endoleaks. This allows for accurate localization of leaks, which is critical for management planning.
Pentosan polysulfate in patients with bladder pain syndrome/interstitial cystitis with Hunner’s lesions or glomerulations: systematic review and meta-analysis
Authors: Grigoryan Bagrat , Kasyan George , Pivazyan Laura , Pushkar Dmitry 
Published: June 2022

Background: Bladder pain syndrome/interstitial cystitis (BPS/IC) is a persistent pain perceived in the urinary bladder region, accompanied by at least one symptom, such as pain worsening with bladder filling and daytime or nighttime urinary frequency without any proven infection or obvious pathology. The aim of this study is to evaluate the efficacy and safety of pentosan polysulfate (PPS) in patients with BPS/IC. Methods: Systematic search was performed by PRISMA checklist. Electronic databases, including PubMed and Cochrane library, were checked until 2021 using keywords: ‘pentosan polysulfate’, ‘pain syndrome’, ‘interstitial cystitis’, and bibliography of relevant papers was checked. Inclusion criteria: Patients with confirmed diagnosis of BPS/IC and cystoscopy criteria – Hunner’s lesions. Exclusion criteria included hypersensitivity, pregnancy, lactation, and oral therapy for BPS/IC in the period of 1 month before the study and abstracts or unpublished papers. Results: In total, 13 clinical trials were included in systematic review and 7 were included in meta-analysis. Studies evaluated the effectiveness and safety of oral PPS versus placebo or other treatment options. In the first meta-analysis, three studies compared oral PPS with placebo: [relative risk (RR) = 2.07, 95% confidence interval (CI): 1.37–3.13, p = 0.0006]. The second meta-analysis of two studies compared oral PPS with another treatment options (intravesical liposome and CyA): (RR = 0.44, 95% CI: 0.10–1.93, p = 0.28). The third meta-analysis of two studies included intravesical regimen of PPS compared with intravesical placebo: (RR = 1.09, 95% CI: 0.54–2.22, p = 0.80). The majority of studies do not report any particular serious side effects. Conclusion: PPS treatment has a statistically significant effect over placebo on the subjective improvement of patients with BPS/IC. There was no difference between PPS and other treatment options. Intravesical regimen of PPS had no significant impact on response rates. None of included studies reported severe side effects after intervention.
Serum vitamin B12 levels and glycemic fluctuation in patients with type 2 diabetes mellitus
Authors: Li Wei , Zhao Jing , Zhu Ling-Ling , Peng You-Fan 
Published: June 2022

Purpose: The aim of the study was to explore the correlation between serum vitamin B12 levels and glycemic fluctuation in patients with type 2 diabetes mellitus (T2DM). Methods: This study included 202 T2DM patients in whom blood glucose levels were recorded using a continuous glucose monitoring system retrospectively. Glycemic fluctuation was determined using the average daily risk range (ADRR), a diabetes-specific measure of the risk for hyper- and hypoglycemia. Results: Serum vitamin B12 levels were higher in T2DM patients with wider glycemic fluctuations than in those with minor glycemic fluctuations ( p < 0.001). We observed a positive correlation between serum vitamin B12 levels and ADRR in both T2DM patients who received and did not receive metformin therapy ( r = 0.388, p < 0.001 and r = 0.280, p = 0.004, respectively). Multiple linear regression analysis showed that serum vitamin B12 levels were independently correlated with ADRR in T2DM patients who received and did not receive metformin therapy (beta = 0.367, p < 0.001 and beta = 0.410, p < 0.001, respectively). Conclusions: Serum vitamin B12 levels are correlated with glycemic fluctuation in patients with T2DM and may serve as an underlying useful biomarker of glycemic fluctuation in T2DM patients, treated with or without metformin therapy.
Protocol for a Multistage Mixed-Methods Evaluation of Multidisciplinary Chronic Kidney Disease Care Quality Following Integration of Virtual and In-Person Care During the COVID-19 Pandemic
Authors: Bevilacqua Micheli , Chiu Helen , Melnyk Yuriy , Williams Janet , Chohan Robin , Wei Julie , Stoll Dominik , Fryer Michele , McGuire Marlee , Logie Anne , Watson Paul , Levin Adeera 
Published: June 2022

Background: Multidisciplinary care of patients with chronic kidney disease (CKD) as it previously existed was predicated on an evidence and experience base of improved patient outcomes within an established and well-described service delivery model. The onset of the COVID-19 pandemic brought with it a departure from this established care delivery model toward integration of virtual care and in-person care. Objective: To develop an evaluation framework to determine whether this shift in service delivery models has affected quality of multidisciplinary kidney care and/or patient-clinician interactions and relationships. Design: A sequential multiphase, mixed-methods evaluation. Setting: All 15 British Columbia (BC) multidisciplinary kidney care clinics (KCCs). Participants: All patients and all clinicians in all KCCs across BC will be invited to participate in the planned evaluation. Measurements: Qualitative and quantitative feedback from patients and families living with CKD and KCC clinicians. Methods: The planned multiphase evaluation of virtual care integration in KCCs will be conducted across all 15 KCCs in the province of BC, Canada. The following phases are proposed: (1) review of current virtual care integration and practices, (2) assessment of patient and clinician experiences and perspectives via semi-structured interviews, (3) validation of those patient and clinician perspectives via survey of a larger sample, (4) compilation and analysis of all phases to provide informed recommendations for patient and visit format selection in a mixed in-person and virtual multidisciplinary clinic setting. Limitations: This work will not capture any information about the relationship between differences in virtual usage parameters and clinical outcomes or financial implications. Conclusions: There is no existing framework for either evaluation of multidisciplinary CKD care quality in a virtual setting or evaluation of care quality following a substantial change in service delivery models. The proposed evaluation protocol will enable better understanding of the nuances in kidney care delivery in this new format and inform how best to optimize the integration of virtual and pre-existing formats into kidney clinic care delivery beyond the pandemic. Beyond the current evaluation, this protocol may be of use for other jurisdictions to evaluate their own local instances of virtual care implementation and integration. The model may be adapted to evaluate quality of multidisciplinary kidney care delivery following other changes to clinic service delivery models.
Endovascular treatment in patients with acute ischemic stroke and cancer: Systematic review and meta-analysis
Authors: Caimano Danilo , Letteri Federica , Capasso Francesco , Limbucci Nicola , Nencini Patrizia , Sarti Cristina , Alemseged Fana , Bigliardi Guido , Morotti Andrea , Toni Danilo , Zini Andrea , Arba Francesco 
Published: June 2022

Introduction: Although stroke occurs frequently in patients with cancer, there is scarce evidence regarding the safety and efficacy of endovascular treatment (EVT) in patients with acute ischemic stroke and concurrent cancer. We performed a systematic review and meta-analysis to summarize the existing literature. Methods: We searched for English written observational studies reporting data on safety and efficacy of EVT in patients with acute ischemic stroke and concurrent cancer. Outcomes of interest were: functional independence (modified Rankin Scale (mRS) ⩽ 2); mortality at 3 months; rate of successful recanalization (modified Treatment In Cerebral Ischemia (mTICI) 2b or 3); occurrence of any hemorrhagic transformation (both symptomatic and asymptomatic). We pooled data with Maentel-Haenszel model to calculate cumulative odds ratios (ORs). Results: We included seven studies with a total of 4465 patients, of whom 262 (6%) with cancer. We observed various definitions of cancer across included studies. Patients with cancer had less likely mRS⩽2 at 3 months (24% vs 42%, OR = 0.44; 95% CI = 0.32–0.60) and increased probability of death (43% vs 19%, OR = 5.02; 95% CI = 2.90–8.69). There was no difference in successful recanalization (70% vs 75%, OR = 0.84; 95% CI = 0.49–1.44); patients with cancer had increased risk of any intracerebral hemorrhage after treatment (49% vs 34%, OR = 1.95; 95% CI = 1.28–2.96), though not for symptomatic ICH (OR 1.04; 95% CI = 0.59–1.85). Conclusion: Patients with acute ischemic stroke and cancer have similar EVT recanalization but higher probability of functional dependence, death, and any hemorrhagic transformation, though not necessarily symptomatic, compared with patients without cancer. Our results may help communication with patients and carers.
Anticoagulation in hospitalized patients with COVID-19
Authors: Baumann Kreuziger Lisa , Sholzberg Michelle , Cushman Mary 
Published: June 2022

Abstract
Coronavirus disease-19 (COVID-19) includes a thromboinflammatory syndrome that may manifest with microvascular and macrovascular thrombosis. Patients with COVID-19 have a higher incidence of venous thromboembolism than other hospitalized patients. Three randomized control trials suggesting benefit of therapeutic heparin in hospitalized noncritically ill patients with COVID-19 have led to conditional guideline recommendations for this treatment. By contrast, prophylactic-dose heparin is recommended for critically ill patients. Unprecedented collaboration and rapidly funded research have improved care of hospitalized patients with COVID-19.
Recurrent noncoding somatic and germline WT1 variants converge to disrupt MYB binding in acute promyelocytic leukemia
Authors: Song Huan , Liu Yabin , Tan Yun , Zhang Yi , Jin Wen , Chen Li , Wu Shishuang , Yan Jinsong , Li Junmin , Chen Zhu , Chen Saijuan , Wang Kankan 
Published: June 2022

Abstract
Genetic alternations can occur at noncoding regions, but how they contribute to cancer pathogenesis is poorly understood. Here, we established a mutational landscape of cis-regulatory regions (CREs) in acute promyelocytic leukemia (APL) based on whole-genome sequencing analysis of paired tumor and germline samples from 24 patients and epigenetic profiling of 16 patients. Mutations occurring in CREs occur preferentially in active enhancers bound by the complex of master transcription factors in APL. Among significantly enriched mutated CREs, we found a recurrently mutated region located within the third intron of WT1, an essential regulator of normal and malignant hematopoiesis. Focusing on noncoding mutations within this WT1 intron, an analysis on 169 APL patients revealed that somatic mutations were clustered into a focal hotspot region, including one site identified as a germline polymorphism contributing to APL risk. Significantly decreased WT1 expression was observed in APL patients bearing somatic and/or germline noncoding WT1 variants. Furthermore, biallelic WT1 inactivation was recurrently found in APL patients with noncoding WT1 variants, which resulted in the complete loss of WT1. The high incidence of biallelic inactivation suggested the tumor suppressor activity of WT1 in APL. Mechanistically, noncoding WT1 variants disrupted MYB binding on chromatin and suppressed the enhancer activity and WT1 expression through destroying the chromatin looping formation. Our study highlights the important role of noncoding variants in the leukemogenesis of APL.