bluuebunny/crossref_metadata_2025_split huggingface dataset:
Heart failure and the risk of left atrial thrombus formation in patients with atrial fibrillation or atrial flutter
Authors: Wybraniec Maciej T. , Mizia‐Szubryt Magdalena , Cichoń Małgorzata , Wrona‐Kolasa Karolina , Kapłon‐Cieślicka Agnieszka , Gawałko Monika , Budnik Monika , Uziębło‐Życzkowska Beata , Krzesiński Paweł , Starzyk Katarzyna , Gorczyca‐Głowacka Iwona , Daniłowicz‐Szymanowicz Ludmiła , Kaufmann Damian , Wójcik Maciej , Błaszczyk Robert , Hiczkiewicz Jarosław , Łojewska Katarzyna , Kosmalska Katarzyna , Fijałkowski Marcin , Szymańska Anna , Wiktorska Anna , Haberka Maciej , Kucio Michał , Michalski Błażej , Kupczyńska Karolina , Tomaszuk‐Kazberuk Anna , Wilk‐Śledziewska Katarzyna , Wachnicka‐Truty Renata , Koziński Marek , Burchardt Paweł , Mizia‐Stec Katarzyna 
Published: August 2022

AbstractAimsThe aim of the study was to evaluate the prevalence of left atrial thrombus (LAT) on transoesophageal echocardiography (TOE) in patients with atrial fibrillation or atrial flutter (AF/AFl) with reference to the presence of heart failure (HF) and its subtypes.Methods and resultsThe research is a sub‐study of the multicentre, prospective, observational Left Atrial Thrombus on Transoesophageal Echocardiography (LATTEE) registry, which comprised 3109 consecutive patients with AF/AFl undergoing TOE prior to direct current cardioversion or catheter ablation. TOE parameters, including presence of LAT, were compared between patients with and without HF and across different subtypes of HF, including HF with preserved (HFpEF), mid‐range (HFmrEF), and reduced ejection fraction (HFrEF). HF was diagnosed in 1336 patients (43%). HF patients had higher prevalence of LAT than non‐HF patients (12.8% vs. 4.4%; P < 0.001). LAT presence increased with more advanced type of systolic dysfunction (HFpEF vs. HFmrEF vs. HFrEF: 7.4% vs. 10.5% vs. 20.3%; P < 0.001). Univariate analysis revealed that HFrEF (odds ratio [OR] 4.13; 95% confidence interval [95% CI]: 3.13–5.46), but not HFmrEF or HFpEF, was associated with the presence of LAT. Multivariable logistic regression indicated that lower left ventricular ejection fraction (OR per 1%: 0.94; 95% CI 0.93–0.95) was an independent predictor of LAT formation. Receiver operator characteristic analysis showed LVEF ≤48% adequately predicted increased risk of LAT presence (area under the curve [AUC] 0.74; P < 0.0001).ConclusionThe diagnosis of HFrEF, but neither HFmrEF nor HFpEF, confers a considerable risk of LAT presence despite widespread utilization of adequate anticoagulation.
Congestion in heart failure: a circulating biomarker‐based perspective. A review from the Biomarkers Working Group of the Heart Failure Association, European Society of Cardiology
Authors: Núñez Julio , de la Espriella Rafael , Rossignol Patrick , Voors Adriaan A. , Mullens Wilfried , Metra Marco , Chioncel Ovidiu , Januzzi James L. , Mueller Christian , Richards A. Mark , de Boer Rudolf A. , Thum Thomas , Arfsten Henrike , González Arantxa , Abdelhamid Magdy , Adamopoulos Stamatis , Anker Stefan D. , Gal Tuvia Ben , Biegus Jan , Cohen‐Solal Alain , Böhm Michael , Emdin Michele , Jankowska Ewa A. , Gustafsson Finn , Hill Loreena , Jaarsma Tiny , Jhund Pardeep S. , Lopatin Yuri , Lund Lars H. , Milicic Davor , Moura Brenda , Piepoli Massimo F. , Ponikowski Piotr , Rakisheva Amina , Ristic Arsen , Savarese Gianluigi , Tocchetti Carlo G. , Van Linthout Sophie , Volterrani Maurizio , Seferovic Petar , Rosano Giuseppe , Coats Andrew J.S. , Bayes‐Genis Antoni 
Published: August 2022

AbstractCongestion is a cardinal sign of heart failure (HF). In the past, it was seen as a homogeneous epiphenomenon that identified patients with advanced HF. However, current evidence shows that congestion in HF varies in quantity and distribution. This updated view advocates for a congestive‐driven classification of HF according to onset (acute vs. chronic), regional distribution (systemic vs. pulmonary), compartment of distribution (intravascular vs. extravascular), and clinical vs. subclinical. Thus, this review will focus on the utility of circulating biomarkers for assessing and managing the different fluid overload phenotypes. This discussion focused on the clinical utility of the natriuretic peptides, carbohydrate antigen 125 (also called mucin 16), bio‐adrenomedullin and mid‐regional pro‐adrenomedullin, ST2 (also known as interleukin‐1 receptor‐like 1), cluster of differentiation 146, troponin, C‐terminal pro‐endothelin‐1, and parameters of haemoconcentration. The utility of circulation biomarkers on top of clinical evaluation, haemodynamics, and imaging needs to be better determined by dedicated studies. Some multiparametric frameworks in which these tools contribute to management are proposed.
Approach Toward Reversal of Chemoselectivity in Catalytic Silylation of Pyranosides
Authors: Hashimoto Hisashi , Ueda Yoshihiro , Fujimura Koki , Takasu Kiyosei , Kawabata Takeo 
Published: August 2022

AbstractIt is widely recognized that primary hydroxy groups show much higher reactivity than the secondary ones, especially in trialkylsilylation. Actually, DMAP‐catalyzed silylation of unprotected pyranosides gave the 6‐O‐silylate exclusively by silylation of the primary C(6)−OH. On the other hand, catalystent‐C1overcame the general tendency of silylation, and enabled the selective silylation of the secondary C(3)−OH of two β‐glucopyranosides and a β‐galactopyranoside. Although the yields of the silylation are poor at this stage, this is the first example of selective silylation of the secondary hydroxy group in the presence of the free primary C(6)−OH of pyranosides under the catalyst‐controlled conditions.
Effect of metals on the regulation of acidogenic metabolism enhancing biohydrogen and carboxylic acids production from brewery spent grains: Microbial dynamics and biochemical analysis
Authors: Sarkar Omprakash , Rova Ulrika , Christakopoulos Paul , Matsakas Leonidas 
Published: August 2022

AbstractThe present study reports the mixed culture acidogenic production of biohydrogen and carboxylic acids (CA) from brewery spent grains (BSG) in the presence of high concentrations of cobalt, iron, nickel, and zinc. The metals enhanced biohydrogen output by 2.39 times along with CA biosynthesis by 1.73 times. Cobalt and iron promoted the acetate and butyrate pathways, leading to the accumulation of 5.14 gCOD/L of acetic and 11.36 gCOD/L of butyric acid. The production of solvents (ethanol + butanol) was higher with zinc (4.68 gCOD/L) and cobalt (4.45 gCOD/L). A combination of all four metals further enhanced CA accumulation to 42.98 gCOD/L, thus surpassing the benefits accrued from supplementation with individual metals. Additionally, 0.36 and 0.31 mol green ammonium were obtained from protein‐rich brewery spent grain upon supplementation with iron and cobalt, respectively. Metagenomic analysis revealed the high relative abundance of Firmicutes (>90%), of which 85.02% were Clostridium, in mixed metal‐containing reactors. Finally, a significant correlation of dehydrogenase activity with CA and biohydrogen evolution was observed upon metal addition.
The BEEHAVEecotox Model—Integrating a Mechanistic Effect Module into the Honeybee Colony Model
Authors: Preuss Thomas G. , Agatz Annika , Goussen Benoit , Roeben Vanessa , Rumkee Jack , Zakharova Liubov , Thorbek Pernille 
Published: August 2022

Abstract
Mechanistic effect models are powerful tools for extrapolating from laboratory studies to field conditions. For bees, several good models are available that can simulate colony dynamics. Controlled and reliable experimental systems are also available to estimate the inherent toxicity of pesticides to individuals. However, there is currently no systematic and mechanistic way of linking the output of experimental ecotoxicological testing to bee models for bee risk assessment. We introduce an ecotoxicological module that mechanistically links exposure with the hazard profile of a pesticide for individual honeybees so that colony effects emerge. This mechanistic link allows the translation of results from standard laboratory studies to relevant parameters and processes for simulating bee colony dynamics. The module was integrated into the state-of-the-art honeybee model BEEHAVE. For the integration, BEEHAVE was adapted to mechanistically link the exposure and effects on different cohorts to colony dynamics. The BEEHAVEecotox model was tested against semifield (tunnel) studies, which were deemed the best study type to test whether BEEHAVEecotox predicted realistic effect sizes under controlled conditions. Two pesticides used as toxic standards were chosen for this validation to represent two different modes of action: acute mortality of foragers and chronic brood effects. The ecotoxicological module was able to predict effect sizes in the tunnel studies based on information from standard laboratory tests. In conclusion, the BEEHAVEecotox model is an excellent tool to be used for honeybee risk assessment, interpretation of field and semifield studies, and exploring the efficiency of different mitigation measures. The principles for exposure and effect modules are portable and could be used for any well-constructed honeybee model. Environ Toxicol Chem 2022;41:2870–2882. © 2022 Bayer AG & Sygenta, et al. Environmental Toxicology and Chemistry published by Wiley Periodicals LLC on behalf of SETAC.
Development of a Site-Specific Guideline Value for Copper and Aquatic Life in Tropical Freshwaters of Low Hardness
Authors: Trenfield Melanie A. , Walker Samantha L. , Tanneberger Claudia , Kleinhenz Linda S. , Harford Andrew J. 
Published: August 2022

Abstract
Copper (Cu) is a contaminant of potential concern for a uranium mine whose receiving waters are in the World Heritage–listed Kakadu National Park in northern Australia. The physicochemical characteristics of the freshwaters in this region enhance metal bioavailability and toxicity. Seven tropical species were used to assess the chronic toxicity of Cu in extremely soft freshwater from a creek upstream of the mine. Sensitivity to Cu was as follows: Moinodaphnia macleayi &gt; Chlorella sp. &gt; Velesunio sp. &gt; Hydra viridissima &gt; Amerianna cumingi &gt; Lemna aequinoctialis &gt; Mogurnda mogurnda. The 10% effect concentrations (EC10s) ranged from 1.0 µg/L Cu for the cladoceran Moinodaphnia macleayi to 9.6 µg/L for the fish M. mogurnda. The EC50s ranged from 6.6 µg/L Cu for the mussel Velesunio sp. to 22.5 µg/L Cu for M. mogurnda. Geochemical modeling predicted Cu to be strongly bound to fulvic acid (80%–99%) and of low bioavailability (0.02%–11.5%) under these conditions. Protective concentrations (PCs) were derived from a species sensitivity distribution for the local biota. The 99% PC (PC99), PC95, PC90, and PC80 values were 0.5, 0.8, 1.0, and 1.5 µg/L Cu, respectively. These threshold values suggest that the current Australian and New Zealand default national 99% protection guideline value for Cu (1.0 µg/L) would not provide adequate protection in freshwaters of low hardness, particularly for this area of high conservation value. The continuous criterion concentration predicted by the Cu biotic ligand model for conditions of low pH (6.1), low dissolved organic carbon (2.5 mg/L), low hardness (3.3 mg/L), and 27 °C was 0.48 µg/L Cu, comparable with the PC99. Consideration of the natural water quality conditions of a site is paramount for protective water quality guidelines. Environ Toxicol Chem 2022;41:2808–2821. © 2022 Commonwealth of Australia. Environmental Toxicology and Chemistry © 2022 SETAC.
Nine new species of Piper sect. Isophyllon Miq. (Piperaceae) from Brazil
Authors: de Queiroz George Azevedo , Guimarães Elsie Franklin , Sakuragui Cássia Mônica 
Published: August 2022

AbstractPiper section Isophyllon comprised about 120 species with a Neotropical distribution, with the greatest diversity occurring in Central America and the Brazilian Atlantic Forest. Based on analysis of the largest Brazilian herbaria, we describe nine new species of Piper sect. Isophyllon: P. arianeae G.A. Queiroz, Sarnaglia & E.F. Guim.; P. forzzae G.A. Queiroz & E.F. Guim.; P. jaramilloae G.A. Queiroz & E.F. Guim.; P. marquetii G.A. Queiroz, E.F. Guim. & Sarnaglia; P. martinellii G.A. Queiroz & E.F. Guim.; P. michelineae G.A. Queiroz & E.F. Guim.; P. moreiranum G.A. Queiroz & E.F. Guim.; P. rizzinii G.A. Queiroz & E.F. Guim.; and P. sucreanum G.A. Queiroz & E.F. Guim. In addition to the taxonomical descriptions, illustrations, maps, and comments, we provide an identification key for the Brazilian species of this group.
Thermogelling hydrogel charge and lower critical solution temperature influence cellular infiltration and tissue integration in an ex vivo cartilage explant model
Authors: Pearce Hannah A. , Swain Joseph W. R. , Victor Luis Hector , Hogan Katie J. , Jiang Emily Y. , Bedell Matthew L. , Navara Adam M. , Farsheed Adam , Kim Yu Seon , Guo Jason L. , Hartgerink Jeffrey D. , Grande‐Allen K. Jane , Mikos Antonios G. 
Published: August 2022

AbstractThermogelling hydrogels based on poly(N‐isopropyl acrylamide) (p[NiPAAm]) and crosslinked with a peptide‐bearing macromer poly(glycolic acid)‐poly(ethylene glycol)‐poly(glycolic acid)‐di(but‐2‐yne‐1,4‐dithiol) (PdBT) were fabricated to assess the role of hydrogel charge and lower critical solution temperature (LCST) over time in influencing cellular infiltration and tissue integration in an ex vivo cartilage explant model over 21 days. The p(NiPAAm)‐based thermogelling polymer was synthesized to possess 0, 5, and 10 mol% dimethyl‐γ‐butyrolactone acrylate (DBA) to raise the LCST over time as the lactone rings hydrolyzed. Further, three peptides were designed to impart charge into the hydrogels via conjugation to the PdBT crosslinker. The positively, neutrally, and negatively charged peptides K4 (+), zwitterionic K2E2 (0), and E4 (−), respectively, were conjugated to the modular PdBT crosslinker and the hydrogels were evaluated for their thermogelation behavior in vitro before injection into the cartilage explant models. Samples were collected at days 0 and 21, and tissue integration and cellular infiltration were assessed via mechanical pushout testing and histology. Negatively charged hydrogels whose LCST changed over time (10 mol% DBA) were demonstrated to promote the greatest tissue integration when compared to the positive and neutral gels of the same thermogelling polymer formulation due to increased transport and diffusion across the hydrogel‐tissue interface. Indeed, the negatively charged thermogelling polymer groups containing 5 and 10 mol% DBA demonstrated cellular infiltration and cartilage‐like matrix deposition via histology. This study demonstrates the important role that material physicochemical properties play in dictating cell and tissue behavior and can inform future cartilage tissue engineering strategies.
The depth of stories: How Black young adults' disclosure of high arousal negative affect in narratives about the COVID‐19 pandemic and the BLM protests improved adjustment over the year 2020
Authors: Audet Élodie C. , Thai Helen , Holding Anne C. , Davids John , Fang Xiaoyan , Koestner Richard 
Published: August 2022

AbstractThe present study investigates whether the way Black young adults constructed their narratives regarding the stressful events of the COVID‐19 pandemic and the black lives matter (BLM) protests related to adjustment over time. A two‐wave mixed prospective and retrospective longitudinal study was conducted in July and December 2020 and included a total of 90 Black young adults. Narrative reports were collected at baseline to determine the psychological interpretations of the two events and were coded based on affect disclosure. Both time points examined adjustment to the COVID‐19 pandemic and the BLM protests as well as the extent to which the basic psychological needs for autonomy, relatedness, and competence were affected. Our results showed that disclosure of high arousal negative affect in narratives at baseline was associated with better adjustment over time. Additionally, results of process analyses showed that satisfaction of the basic psychological need for autonomy (e.g., feelings of personal agency, choice, and volition) mediated the association between narratives and adjustment. These results suggest that engaging in disclosure of high arousal negative affect may be associated with heightening adjustment because it enhances individuals' autonomy, perhaps resulting in a beneficial integration of the events into their broader life narratives. These findings highlight the potential of well‐constructed narratives to impact adjustment over time and have implications for clinical practice to support Racialized communities during unprecedented events.
Locating longitudinal study participants 10 years after last contact: Contemporary approaches to sample retention
Authors: Dimakos Christina , Loomis Colleen , Gilmer Alexis , Wright Carrie , Christens Brian D. , Pelletier Janette , Peters Ray DeV. 
Published: August 2022

AbstractAimsDespite their advantages, longitudinal studies often face high rates of attrition. This study documents the extensive efforts associated with retaining a longitudinal cohort last contacted 10 years earlier.MethodWe examine the processes and outcomes of attempts to reach 1736 individuals who have been part of a multiwave study about growing up in Ontario, Canada. Contact methods include email, phone, text, social media, postal mail, announcements in newspapers, subway stations, and music streaming services.ResultsChallenges included a lack of consistent annual communication with participants, children moving out of the parental home, and changes in email addresses and phone numbers. The most effective contact method was phone; text messages and friend referrals were the least effective. Overall, 41.5% of the original sample was reached. Locating former research participants years later necessitated multiple and repeated contact attempts, and intensive human resources.ConclusionTen lessons for effective sample retention are discussed. In summary, reducing attrition depends on a comprehensive study design and an organized and flexible protocol that adapts to a study's ever‐changing needs.
Effectiveness and Safety of Histamine H2 Receptor Antagonists: An Umbrella Review of Meta‐Analyses
Authors: Meng Rui , Chen Li‐Rong , Zhang Man‐Li , Cai Wen‐Ke , Yin Sun‐Jun , Fan Yu‐Xin , Zhou Tao , Huang Yan‐Hua , He Gong‐Hao 
Published: August 2022

AbstractHistamine H2 receptor antagonists (H2RAs) were widely used to inhibit gastric acid secretion, but its association with adverse events remains controversial and unclear. We conducted an umbrella review of meta‐analyses to systematically assess the quality and credibility of the correlations between H2RA use with the risk of adverse outcomes through searching 4 major databases from inception to April 30, 2022. Forty‐six individual meta‐analyses were identified, including 29 meta‐analyses of observation studies with 32 unique outcomes and 19 meta‐analyses of randomized controlled trials with 3 unique outcomes for comparing the H2RA versus non‐H2RA group. A Measurement Tool to Assess Systematic Reviews 2 rating for the included meta‐analyses showed that 4 of 46 meta‐analyses were assigned as high scores, 3 were assigned as “moderate,” and 25 were assigned as low scores. Grading of Recommendations Assessment, Development and Evaluation assessment for combined results demonstrated that 6 outcomes were rated as “moderate,” 9 outcomes were rated as “low,” and 17 outcomes were rated as “very low.” We confirmed significant associations of H2RA use with pneumonia, peritonitis, necrotizing enterocolitis, Clostridium difficile infection, liver cancer, gastric cancer, and hip fracture diseases. No associations for colorectal cancer, melanoma, kidney cancer, lung cancer, or common reproductive system cancer or renal, neurological, and cardiovascular system diseases were observed. We found a variety of evidence for the associations between H2RAs and adverse outcomes, which would give clinicians more positive guidance on prescription of H2RAs in clinical practice.
Extravasation injury management for neonates and children: A systematic review and aggregated case series
Authors: Dufficy Mitchell , Takashima Mari , Cunninghame Jacqueline , Griffin Bronwyn R. , McBride Craig A. , August Deanne , Ullman Amanda J. 
Published: August 2022

AbstractBackgroundPediatric extravasation injuries are significant healthcare‐associated injuries, with sometimes significant sequelae. Evidence‐based guidance on management is necessary to prevent permanent injury.PurposeA systematic review of the literature, including aggregated case series, investigating extravasation injury management of hospitalized pediatric patients.Data SourcesPubMed, Cummulative Index to Nursing and Allied Health Literature (CINAHL), and Excerpta Medica database (EMBASE) were searched on December 13, 2021.Study SelectionPrimary research investigating extravasation injury management of hospitalized pediatric patients (to 18 years), published from 2010 onwards and in English, independently screened by two authors, with arbitration from a third author.Data ExtractionData regarding the study, patient (age, primary diagnosis), extravasation (site, presentation, outcome), and treatment (first aid, wound management) were extracted by two authors, with arbitration from a third author.Data SynthesisFrom an initial 1769 articles, 27 studies were included with extractable case data reported in 18 studies, resulting in 33 cases. No clinical trials were identified, instead, studies were primarily case studies (52%) of neonates (67%), with varied extravasation symptoms. Studies had good selection and ascertainment, but few met the causality and reporting requirements for quality assessments. Signs and symptoms varied, with scarring (45%) and necrosis (30%) commonly described. Diverse treatments were categorized into first aid, medical, surgical, and dressings.ConclusionsDespite infiltration and extravasation injuries being common within pediatric healthcare, management interventions are under‐researched, with low‐quality studies and no consensus on treatments or outcomes.
A morphological analysis of carnivoran ossicles from Rancho La Brea
Authors: Dickinson Edwin , Elminowski Erin E. , Flores Deanna , Eldridge Emma I. , Granatosky Michael C. , Hartstone‐Rose Adam 
Published: August 2022

AbstractThe morphology of the mammalian middle ear—including the size, shape, and stiffness of individual ossicles—controls their vibrational response to sound and, is closely related to an animal's auditory capabilities. While the relationship between middle ear morphology and hearing frequency has been explored in living carnivorans, the size and shape of ossicles in fossil carnivorans have been sparsely documented. In this study, we present the first morphological data on four iconic carnivoran taxa from the Rancho La Brea Tar Pits: Smilodon fatalis, Panthera atrox, Canis dirus, and Arctodus simus. These data are contextualized with samples of extant felids, canids, and ursids to determine the extent to which the ossicles of these iconic fossil taxa resemble their living relatives. Six, five, and seven linear measurements were taken from the malleus, incus, and stapes, respectively. Comparisons of geometric means reveal that the ossicles of fossil canids and felids are similar in size to living analogs, but those of A. simus are significantly larger than those of any living ursid. Further, principal components analyses demonstrate close morphological affinities between fossil and extant taxa within canids and felids, and again, a greater disparity between fossil and extant ursids. Canids and ursids occupy distinct regions of the morphospace, yet both overlap the morphological range spanned by felids. While some elements—for example, the stapes—require further specimens to facilitate more nuanced interpretations of variation, our findings underscore the need for concerted efforts towards identifying and preserving these bones within fossil assemblages.