bluuebunny/crossref_metadata_2025_split huggingface dataset:
Preoperative computed tomography-guided soft hook-wire localization for multiple pulmonary nodules
Authors: Li Guang-Chao , Wu Zheng-Long , Shi Yi-Bing , Wang Jing-Ya , Fu Yu-Fei 
Published: February 2025

BackgroundWhile there have been prior reports on pulmonary nodule (PN) localization through computed tomography (CT)-guided soft hook-wire (SHW) placement, there remains a dearth of studies specifically focused on the CT-guided SHW localization of multiple PNs. This study was thus designed to specifically evaluate the efficacy and safety of this localization strategy in patients with multiple PNs.MethodsIn total, 43 consecutive patients with multiple PNs underwent CT-guided SHW localization followed by video-assisted thoracoscopic surgery (VATS) to resent these PNs in our hospital between January 2022 and December 2022. A control group consisting of 140 individuals who underwent the CT-guided SHW localization of a single PN during the same interval was also selected. Both groups were analyzed retrospectively for safety and efficacy outcomes.ResultsThe final study population included 43 patients (94 PNs) in the multiple PN group, and 140 patients (140 PNs) in the single PN group, with all patients having undergone CT-guided SHW localization of these PNs. A one-stage procedure was employed for the localization of multiple PNs. The respective rates of technical success for SHW localization in the multiple and single PN groups were 98.9% and 100% (P = 0.402). The duration of localization in the multiple PN group was significantly longer than that in the single PN group (P = 0.001). The respective pneumothorax rates in the multiple and single PN groups were 32.5% (14/43) and 15.7% (22/140) (P = 0.015), while the corresponding lung hemorrhage incidence rates were 48.8% (21/43) and 36.4% (51/140) (P = 0.145). All PNs successfully underwent limited VATS resection, with a one-stage VATS procedure having been used for the resection of multiple PNs in a given patient.ConclusionsCT-guided SHW localization is a safe and effective means of localizing multiple PNs in a single patient. This simultaneous localization of multiple PNs can provide effective guidance for the subsequent one-stage limited VATS resection of these nodules.
Association of ANA and SSA autoantibodies with progression-free survival in multiple myeloma: a retrospective cohort study
Authors: Zhang Jiafeng , Ren Hefei , Chen Lei , Wang Xin , Wang Huiquan , Wu Hongkun , Zhou Lin 
Published: February 2025

ObjectiveThis study aimed to investigate the relationship between autoantibodies, specifically Antinuclear Antibody (ANA) and anti-Sjögren’s-syndrome-related antigen A (SSA), and progression-free survival (PFS) in multiple myeloma (MM) patients.MethodsA retrospective cohort study was conducted on 304 MM patients diagnosed between 2010 and 2020 at Shanghai Changzheng Hospital, with follow-up until October 2023. Patients were stratified based on ANA and SSA positivity. Clinical data were analyzed using Kaplan-Meier survival curves and Cox regression models, adjusting for key prognostic factors. Sensitivity analyses were performed using propensity score matching (PSM) and inverse probability of treatment weighting (IPTW) to evaluate the robustness of the results.ResultsSSA-positive patients exhibited significantly shorter PFS compared to SSA-negative patients (17 vs. 44 months, HR = 2.93, 95% CI 1.53-5.64, p = 0.001), while ANA positivity was associated with a smaller increase in risk (HR = 1.57, 95% CI 1.04-2.4, p = 0.034). The impact of SSA remained significant after adjusting for various covariates in the Cox regression model and sensitivity analyses. Subgroup analyses revealed consistent effects of SSA positivity across different demographic and clinical factors.ConclusionSSA positivity is associated with a higher risk of disease progression in MM patients, suggesting it may serve as a valuable prognostic marker. The relationship between autoantibodies and MM prognosis warrants further investigation in larger, multicenter studies to elucidate the underlying mechanisms and inform clinical management.
Clinical outcomes of avelumab and pembrolizumab in advanced urothelial cancer: an observational multicenter retro-prospective study on patients undergoing treatment in clinical practice (AVePEm study)
Authors: Zacchi Francesca , Sordo Anna , Torresan Irene , Lorenzi Clara , Tasselli Ester , Pafumi Sarah , Palmerio Silvia , Durante Emilia , Inzerilli Nicola , Pellicciari Mattia , Pastorelli Davide , Milella Michele , Lorenzoni Giulia , Merler Sara , Zivi Andrea 
Published: February 2025

Introduction and objectivesPatients (pts) with metastatic urothelial carcinoma (mUC) gain substantial benefit from immunotherapy exposure. If they do not experience disease progression after 4-6 cycles of first-line platinum-based chemotherapy (PBC), they may benefit from immunotherapy as maintenance treatment with Avelumab; otherwise, Pembrolizumab is an approved second-line therapy after disease progression on first-line chemotherapy. However, no clinical trial data currently demonstrate which treatment strategy offers superior survival outcomes.Patients and methodsThis is a multicenter, observational, retro-prospective study involving pts with mUC who did not progress after 4-6 cycles of PBC: GroupA received Avelumab and GroupB Pembrolizumab. The primary endpoints were overall survival (OS) and progression-free survival (PFS), with neutrophil-to-lymphocyte ratio (NLR) ≥3 at the baseline of PBC and at the start of immunotherapy in predicting outcome, adverse events (AEs), subsequent therapies after the immunotherapy strategy, and costs associated with these treatments as secondary endpoints.ResultsFrom August 2019 to October 2024, we identified 30 pts. Of those, 53% were in GroupA and 47% in GroupB. The mOS in GroupA was 27 mo and in GroupB 26 mo and the mPFS of immunotherapy was 7.5 mo and 5.5 mo. At the time of data analysis, 33% (n=10) of pts were alive and 27% (n=8) on treatment, with 38% (n=3) still receiving Avelumab, and 50% (n=4) and 12% (n=1) on subsequent therapies after Avelumab and Pembrolizumab, respectively. Approximately 55% of patients in both groups had a baseline neutrophil-to-lymphocyte ratio (NLR) ≥3 at the baseline of PBC. No statistically significant association was found between NLR, whether considered as a continuous or dichotomous variable, and overall survival or progression free survival. Both treatments were well tolerated, with Grade 3 AEs in 1 pt on Avelumab and 3 on Pembrolizumab, and no Grade 4 AEs reported.ConclusionsThe two immunotherapy strategies showed no significant differences in OS and PFS. Of note, more pts were on Avelumab treatment at the data cut-off. AEs were similar in the two groups. Further investigation and follow-up are warranted to gain definitive conclusions on optimal mUC management in the era of immunotherapy and immunoconjugates.
Biological treatments for co-occurring eating disorders and psychological trauma: a systematic review
Authors: van Beers Ella , de Vries Irene , Planting Caroline , Christ Carolien , de Beurs Edwin , van den Berg Elske 
Published: February 2025

IntroductionMany people with eating disorders report having experienced childhood maltreatment or a traumatic event prior to developing an eating disorder. Although many people with eating disorders eating disorders have significant traumatic exposure or symptoms of post-traumatic stress disorder, very little research has examined the effects of combined combined treatments for this group. The purpose of this systematic review was to synthesize all existing research on biological treatments for those with eating disorders and psychological trauma, evaluate their safety, and identify future areas of research research in this area to support to support patients with eating disorders and psychological trauma.MethodA multi-step literature search, according to an a priori protocol was performed on PubMed, Embase, APA PsycINFO, Web of Science, Scopus and Cochrane Central. Studies needed to include a biological intervention and report on at least one eating disorder or psychological trauma outcome. Given the limited research in this area, minimal exclusion criteria were applied. A quality assessment of all included studies was completed using the Risk of Bias in Non-Randomized Studies-or Interventions (ROBINS-I) tool.ResultsAfter removing duplicates, 2623 article titles and abstracts were screened, with 43 articles selected for a full-text review. Following the full-text review, 11 articles met the inclusion criteria. The biological treatments examined included repurposed medications (n = 3), ketamine (n = 2), repetitive transcranial magnetic stimulation (rTMS; n = 2), deep brain stimulation (n =1) electroconvulsive therapy (ECT; n = 1), 3,4-methylenedioxymethamphetamine (MDMA; n = 1), and neurofeedback (n = 1). All studies reported on some improvement in either eating disorder or trauma pathology, with the strongest effect for repetitive transcranial magnetic stimulation and MDMA. While some effects were promising, missing data and selective reporting limited the interpretability of the findings. Adverse events across interventions were common.ConclusionAlthough psychological trauma is common in those with eating disorders, very few treatments have been evaluated in this population. Future work should aim to investigate biological treatments for those with co-occurring eating disorders and psychological trauma, as these evolving treatments show potential benefits for this complex group.
Square dance, loneliness, quality of life, and attitude toward aging in middle-aged and older women in China
Authors: Li Ruitong , Yan Qin , Qu Yujia , Wang Yan 
Published: February 2025

BackgroundWith the ongoing advancement of society and the economy, population aging has emerged as an unavoidable global trend, leading to various social issues and exerting a profound impact on the physical and mental well-being of middle-aged and older adults. While women often face greater challenges than men during the aging process, particularly in terms of physical health vulnerabilities, mental health disparities and socioeconomic disadvantages. These factors underscore the importance of studying middle-aged and older women to better address their unique needs and promote healthy aging. Much attention has been paid to how middle-aged and older women can improve healthy aging, positive emotions and subjective well-being through regular physical activity.MethodsUsing 4,819 middle-aged and older women who participated in square dance exercise, structural equation modeling was used to explore the relationship between square dance exercise and attitude toward aging, as well as the chain-mediated effects of loneliness and quality of life.Results(a) Square dance exercise is a positive predictor of attitude toward aging in middle-aged and older women. (b) Loneliness and quality of life moderated the relationship between square dance exercise and attitude toward aging, and their mediating effects included three pathways. (c) The single mediating effect of quality of life was the largest compared to the chain mediating effects of loneliness and loneliness-quality of life.ConclusionThis study aimed to reveal the reduction of loneliness and improvement of quality of life as potential mechanisms in the relationship between square dance exercise and attitude toward aging, and to emphasize that square dance exercise can be effective in promoting positive attitude toward aging and enhancing subjective well-being in middle-aged and older women.
Dynamical and Atmospheric Characterization of the Substellar Companion HD 33632 Ab from Direct Imaging, Astrometry, and Radial-velocity Data*
Authors: El Morsy Mona , Currie Thayne , Bovie Danielle , Kuzuhara Masayuki , Lacy Brianna , Li Yiting , Tobin Taylor , Brandt Timothy D. , Chilcote Jeffrey , Guyon Olivier , Groff Tyler D. , Lozi Julien , Vievard Sebastien , Deo Vincent , Skaf Nour , Bouchy Francois , Boisse Isabelle , Dykes Erica , Kasdin N. Jeremy , Tamura Motohide 
Published: February 2025

Abstract
We present follow-up SCExAO/CHARIS H- and K-band (R ∼ 70) high-contrast integral field spectroscopy and Keck/NIRC2 photometry of directly imaged brown dwarf companion HD 33632 Ab and new radial-velocity data for the system from the SOPHIE spectrograph, complemented by Hipparcos and Gaia astrometry. These data enable more robust spectral characterization compared to lower-resolution spectra from the discovery paper and more than double the available astrometric and radial-velocity baseline. HD 33632 Ab’s spectrum is well reproduced by a field L8.5–L9.5 dwarf. Using the Exo-REM atmosphere models, we derive a best-fit temperature, surface gravity, and radius of T
eff = 1250 K, log(g) = 5, and R = 0.97 R
J, respectively, as well as a solar C/O ratio. Adding the SOPHIE radial-velocity data enables far tighter constraints on the companion’s orbital properties (e.g., i =

47.5

−
4.7

+
2.5

o
) and dynamical mass (

52.8

−
2.4

+
2.6

M
J) than derived from imaging data and Gaia eDR3 astrometry data alone. HD 33632 Ab should be a prime target for multiband imaging and spectroscopy with the James Webb Space Telescope and the Roman Space Telescope’s Coronagraphic Instrument, shedding detailed light on HD 33632 Ab’s clouds and chemistry and providing a key reference point for understanding young exoplanet atmospheres.
Modulation of X-Ray Flux by Obscuration of Neutron Star Boundary Layer
Authors: Török G. , Klimovičová K. , Lančová D. , Matuszková M. , Šrámková E. , Urbanec M. , Čemeljić M. , Šprňa R. , Karas V. 
Published: February 2025

Abstract
The quasiperiodic oscillations (QPOs) observed in the X-ray variability of both black hole (BH) and neutron star (NS) systems provide a tool for probing strong gravity and dense matter equations of state. Nevertheless, the mechanism of QPO modulation in NS systems, where the amplitudes of QPOs with frequencies approaching the kHz range are very high in comparison to BH high-frequency QPOs, remains an unsolved puzzle. Relativistic ray tracing of photons emitted from the immediate vicinity of compact objects has, to date, been used to investigate various mechanisms that explain the observed weak BH QPOs. However, it has not been applied to model the NS QPO signal, which requires incorporating the NS surface and a bright boundary layer (BL) on it. Here, we explore the QPO modulation mechanisms based on the BL obscuration. Using simplified models of axisymmetric oscillations of thick accretion disks (tori), we demonstrate that the disk oscillations drive the high NS QPO amplitudes through BL obscuration, which is relevant, especially for vertical oscillations. We also demonstrate that obscuration effects enable the observability of the Keplerian frequency in the case of disks that decay due to instabilities.
Radial Dependence of Ion Fluences in the 2023 July 17 Solar Energetic Particle Event from Parker Solar Probe to STEREO and ACE
Authors: Muro G. D. , Cohen C. M. S. , Xu Z. , Leske R. A. , Christian E. R. , Cummings A. C. , De Nolfo G. , Desai M. I. , Fraschetti F. , Giacalone J. , Labrador A. , McComas D. J. , Mitchell J. G. , Mitchell D. G. , Rankin J. , Schwadron N. A. , Shen M. , Wiedenbeck M. E. , Bale S. D. , Romeo O. , Vourlidas A. 
Published: February 2025

Abstract
In the latter moments of 2023 July 17, the solar active region (AR) 13363, near the southwestern face of the Sun, was undergoing considerable evolution, which resulted in a significant solar energetic particle (SEP) event measured by Parker Solar Probe’s Integrated Science Investigation of the Sun (IS⊙IS) and near-Earth spacecraft. Remote observations from GOES and CHASE captured two M5.0+ solar flares that peaked at 23:34 and 00:06 UT from the source region. In tandem, STEREO COR2 first recorded a small, narrow coronal mass ejection (CME) emerging at 22:54 UT and then saw a major halo CME emerge at 23:43 UT with a bright, rapidly expanding core and CME-driven magnetic shock with an estimated speed of ∼1400 km s−1. Parker Solar Probe was positioned at 0.65 au, near-perfectly on the nominal Parker spiral magnetic field line, which connected Earth and the AR for a 537 km s−1 ambient solar wind speed at L1. This fortuitous alignment provided the opportunity to examine how the SEP velocity dispersion, energy spectra, elemental composition, and fluence varied from 0.65 to 1 au along a shared magnetic connection to the Sun. We find a strong radial gradient, which is best characterized for H and He as r
−4.0, and most surprisingly, is stronger for O and Fe, which is better described by r
−5.7.
The carbon footprint of citrus exports via the Port of Durban: A container barge system analysis
Authors: Burgstahler Micah , Goedhals-Gerber Leila L. , Human Ben 
Published: February 2025

Background: The Port of Durban in South Africa has faced significant road congestion for many years. To address this, the fresh-produce industry proposed a cross-harbour container-handling barge system. The citrus industry requested this study to evaluate the potential carbon footprint impact of such a system on citrus exports transported in reefer containers around the port.Objectives: This study aimed to assess whether a barge system could reduce the carbon footprint of citrus exports and alleviate road congestion to improve the export supply chain’s efficiency.Method: Using an exploratory case study with primary and secondary data, the research applied a deductive approach to theory development. Carbon emissions were calculated for three scenarios: the current system, the proposed barge system and a combined system.Results: The carbon emissions for the three scenarios are as follows: current system: 25.20 kg CO2e per reefer; proposed system: 17.43 kg CO2e per reefer; and combined system: 20.61 kg CO2e per reefer. However, the proposed system does not have sufficient capacity to handle all the reefer containers in a given citrus season.Conclusion: The combined system is the logical choice. The combined system shows a CO2e emissions saving of approximately 18% per reefer compared to the current system.Contribution: This study explores the carbon reduction and congestion alleviation benefits of a cross-harbour barge system at the Port of Durban. Unlike existing literature on inland waterway barge systems, it provides a port-specific analysis and is among the first to quantify CO2e emissions for citrus exports using a barge system.
Magnetic Resonance Imaging Versus Anthropometric Parameters in Predicting Hamstring Graft Length for Anterior Cruciate Ligament Surgery
Authors: Gupta Govindkumar , Chakraborty Ratnajeet , Shukla Gauravkumar 
Published: February 2025

Abstract

Context:
With the increasing number of anterior cruciate ligament reconstruction (ACLR) surgeries following sports injuries, situations may arise where hamstring graft is found to be inadequate. The authors hypothesized that the harvested hamstring graft length may be predicted preoperatively from both magnetic resonance imaging (MRI) and anthropometric parameters in ACLR surgery.

Aims:
The study aimed at assessing the relationship between anthropometric and MRI parameters and hamstring graft length.

Settings and Design:
The study is a prospective, observational, and comparative study.

Subject and Methods:
A total of 52 patients recruited for ACLR were prospectively evaluated. Anthropometric parameters and Tegner activity score before the injury were recorded. Eight linear MRI measurements were obtained by two observers at an interval of 0 and 30 days. Semitendinosus (ST) and gracilis (G) tendons were harvested and a semitendinosus gracilis (STG) was prepared by a standard technique, and the lengths calculated.

Statistical Analysis Used:
The intra- and inter-rater reliability of the MRI measurements was measured. Pearson’s (r) and Spearman’s (rho) correlation coefficients were calculated, and linear regression analysis was performed to establish a relationship between the preoperative parameters and hamstring graft length.

Results:
The mean graft length for ST was 29.44 ± 1.89 cm and G was 24.44 ± 3.34 cm. The final STG graft length was 8.98 ± 0.19 cm. Transepicondylar distance (TD) had the highest intra- and inter-observer reliability among the MRI measurements. Univariate linear regression analysis revealed that height, weight, thigh length (TL), leg length, and TD were predictive of ST (R
2 range: 0.240–0.380) and G graft (R
2 range: 0.104–0.299) lengths. TL, body mass index, TD, and lateral femoral condyle anteroposterior dimension (LFAP) were predictive of STG graft length (R
2 range: 0.076–0.215). On multiple regression analysis, height and TD were significant predictors of ST (R
2: 0.449) and G lengths (R
2: 0.288).

Conclusions:
Our study concludes that anthropometric parameters may be supplemented with MRI measurements for accurate hamstring graft size predictions.
CD47 plays dual role in colorectal carcinoma, independently on CD 68: an immunohistochemical study
Authors: El Dein Mohamed Asmaa S. , El Hosary Enas M. , Gadallah Marwa S. A. 
Published: February 2025

Background
Colorectal cancer (CRC) is the third most common cancer. Tumor-associated macrophages can affect tumor cell proliferation, stromal formation and dissolution, vascularization, and both pro- and anti-neoplastic inflammation. Cluster of differentiation 68 (CD68) plays a critical role in promoting phagocytosis; however, its function in tumor immunity remains unknown. CD47, a cell-surface receptor expressed by macrophages, provides a potent ‘don’t eat me‘ signal that allows tumor cells to evade immune destruction.

Purpose
Investigate immunohistochemical expression of CD68 and CD47 in CRCs and its correlation with clinicopathological features.

Results
CD68 and epithelial expression of CD47 were significantly in favor of CRC (P value = 0.001, <0.001, respectively) compared with adenoma specimens. Also, high epithelial CD47 was associated with the absence of gross perforation and a higher number of investigated lymph. However, low stromal CD47 was significantly correlated with less tumor metastasis and less tumor recurrence. Moreover, epithelial, and stromal CD47 expression were significantly correlated in CRC. (P=0.033) in CRC.

Conclusion
Both CD68 and CD47 play a role in colorectal carcinogenesis being expressed more in CRC compared with adenoma cases. However, CD47 carries good prognostic impact when expressed by tumor cells in contrary to its stromal expression suggesting dual opposing role of CD47 in CRC according to its localization. So, future target therapy against CD68 or CD47 should be cautiously administered.