bluuebunny/crossref_metadata_2025_split huggingface dataset:
Economic growth, human capital, and energy consumption in Algeria: evidence from cointegrating polynomial regression and a simultaneous equations model
Authors: Bouznit Mohammed , Pablo-Romero María P. , Sánchez-Braza Antonio 
Published: November 2022

AbstractThis article aims to empirically analyze the direct and the indirect effects of human capital on energy consumption in Algeria, as well as to test the possible presence of the energy-environmental Kuznets curve (E-EKC) hypothesis, over the period 1970–2017, using cointegrating polynomial regressions (CPR) with break points, and a simultaneous equations model. The obtained results indicate that human capital directly reduces energy demand, and indirectly increases it through income and physical capital stock channels. However, the direct effect is higher than that of the indirect effect. Additionally, CPR results confirm a monotonic increasing relationship between energy use and real GDP per capita; therefore, there is no evidence of the E-EKC hypothesis. This means that increasing economic growth leads to a rise in energy consumption and, in turn, to an intensification of CO2 emissions. The results also indicate that physical capital stock per capita, urban population ratio, and real GDP per capita are positively linked to energy use per capita. In that context, it may be appropriate to adapt the energy system to the growing demand, promoting greater use of renewable energies, if emissions growth is to be contained. Investment in education and improving the quality of human capital is a good way for Algeria to reduce energy consumption and protect the environment, without negatively impacting economic growth.
Elamipretide effects on the skeletal muscle phosphoproteome in aged female mice
Authors: Campbell Matthew D. , Martín-Pérez Miguel , Egertson Jarrett D. , Gaffrey Matthew J. , Wang Lu , Bammler Theo , Rabinovitch Peter S. , MacCoss Michael , Qian Wei-Jun , Villen Judit , Marcinek David 
Published: November 2022

AbstractThe age-related decline in skeletal muscle mass and function is known as sarcopenia. Sarcopenia progresses based on complex processes involving protein dynamics, cell signaling, oxidative stress, and repair. We have previously found that 8-week treatment with elamipretide improves skeletal muscle function, reverses redox stress, and restores protein S-glutathionylation changes in aged female mice. This study tested whether 8-week treatment with elamipretide also affects global phosphorylation in skeletal muscle consistent with functional improvements and S-glutathionylation. Using female 6–7-month-old mice and 28–29-month-old mice, we found that phosphorylation changes did not relate to S-glutathionylation modifications, but that treatment with elamipretide did partially reverse age-related changes in protein phosphorylation in mouse skeletal muscle.
Technology-Enhanced Learning and Well-being: a Contribution to the Validation of a Measure to Assess University Students’ Technostress in the Italian Context
Authors: Schettino Giovanni , Marino Leda , Capone Vincenza 
Published: November 2022

AbstractCOVID-19 has forced many universities to adopt widely technology-enhanced learning (TEL), highlighting the role of technostress as a risk factor for detrimental outcomes that may be prevented through the assessment with reliable tools. Thus, the present study aimed to test the psychometric characteristics of the Italian validation of the technostress scale by Wang, Tan, and Li. A self-report online questionnaire was completed by 915 participants (aged 18–33 years) attending an online university course during the health emergency. A subsample of 301 subjects (MAge = 20.91, SD = 1.93) filled out the same questionnaire after a 3-month time interval to evaluate the test–retest reliability. Confirmatory factor analysis verified the one-factor structure of the scale, which was confirmed across academic courses considered (first-year and senior students). Moreover, the findings showed significant associations with the Italian Technostress Creators Scale and the Italian Mental Health Continuum–Short Form, as well as a satisfactory test–retest coefficient value supporting its validity and reliability. In light of the above, the study provides a useful instrument to evaluate technostress related to TEL and indications to implement preventive interventions for this type of stress by improving students’ experience with learning technologies.
Substanzkonsum bei Menschen mit geistiger Behinderung: Stand der Forschung, Angebote und Herausforderungen für Hilfesysteme und Prävention
Authors: Rathmann Katharina , Karg Stephanie , Schierenbeck Miriam , Kogel Lisa Marie 
Published: November 2022

Zusammenfassung
Hintergrund
Studien weisen darauf hin, dass der Konsum von stoffgebundenen Substanzen (insbesondere Alkohol und Tabak) von Menschen mit geistiger Behinderung mit der Allgemeinbevölkerung vergleichbar ist. Dies kann durch Maßnahmen zur Umsetzung der UN-Behindertenrechtskonvention und den zunehmenden Bestrebungen der Inklusion, Dezentralisierung, Selbstbestimmung und des Normalisierungsprinzips begründet werden.

Methoden
Auf Grundlage bisheriger Reviews, Studien und Projekte zum Substanzkonsum bei Menschen mit geistiger Behinderung wird ein Überblick über den nationalen und internationalen Forschungsstand zum Substanzkonsum bei Menschen mit geistiger Behinderung gegeben. Zudem sind die Herausforderungen des Substanzkonsums für die Klient*innen und die Hilfesysteme der Sucht- und Behindertenhilfe mit ihren Anforderungen und Aufgaben aufgezeigt. Dabei werden Screeninginstrumente und bisherige Präventionsangebote und -programme dargestellt.

Ergebnisse
Repräsentative Studienergebnisse sind bislang rar. Die angegebenen Häufigkeiten zum Alkohol‑, Tabak- und Cannabiskonsum variieren. Es gibt verhaltens- und verhältnisorientierte Präventionsprogramme für unterschiedliche Zielgruppen. Herausforderungen für die Hilfesysteme ergeben sich z. B. durch Koabhängigkeit und dem Spannungsverhältnis von Selbst- und Fremdbestimmung. An Präventionsansätze sind besondere Anforderungen zu stellen, wie z. B. Lebensweltbezug, zielgruppengerechte Materialien und Methoden sowie wiederholende Elemente und die Einbindung des sozialen Umfelds.

Schlussfolgerung
Im Rahmen der zunehmenden Inklusion sollte dem Thema Substanzkonsum bei Menschen mit geistiger Behinderung stärker Beachtung in Forschung und Praxis geschenkt werden. Für die Prävention von Substanzkonsum sind verhaltens- und verhältnisorientierte Maßnahmen mit aktivierenden Einheiten und zielgruppenspezifische Materialien und Medien, eine stärkere Vernetzung der Hilfesysteme sowie die stärkere Berücksichtigung von (kommunalen) Präventionsketten notwendig.
Frauen in der lokalen Politik und kommunale Wahlbeteiligung. Ein Fall für deskriptive Repräsentation?
Authors: Stocker Simon 
Published: November 2022

ZusammenfassungDiese Studie präsentiert neue empirische Evidenz für die Argumente feministischer Theoretiker*innen, welche die Notwendigkeit deskriptiver Repräsentation von Frauen unterstreichen. Anhand eines neuartigen Datensatzes wird die Wirkung der Präsenz von Frauen in lokalpolitischen Ämtern auf die Beteiligung bei Ratswahlen in Baden-Württemberg untersucht. Die Analyse von Längsschnittdaten zwischen 1999 und 2019 zeigt, dass die Präsenz von Bürgermeisterinnen eine positive Wirkung auf die Beteiligungsquote bei Gemeinderatswahlen hat. Darüber hinaus zeigt sich, dass auch die Offenheit der Wähler*innen für Frauen in politischen Ämtern eine Rolle spielt. Vor allem für Parteien im linken politischen Spektrum spielt emanzipatorische und solidarische Politik und somit Geschlechterausgleich eine wichtige Rolle. In den Gemeinden, in denen die Grünen und die Linkspartei bei der Bundestagswahl höhere Stimmanteile erreichen, ist der positive Effekt deskriptiver Repräsentation von Frauen auf die Wahlbeteiligung größer. Sowohl die Präsenz von Bürgermeisterinnen als auch der Frauenanteil im Gemeinderat haben im Zusammenspiel mit der approximierten Offenheit der Wähler*innen für Politikerinnen einen positiven Effekt auf die Höhe der Wahlbeteiligung. Der positive Effekt der Präsenz von Frauen in lokalpolitischen Ämtern auf die kommunale Wahlbeteiligung wird durch die Offenheit der Wähler*innen gegenüber Politikerinnen moderiert.
Silencing FOXP2 reverses vemurafenib resistance in BRAFV600E mutant papillary thyroid cancer and melanoma cells
Authors: Jiang Suyuan , Huang Yuxin , Li Yuan , Gu Qin , Jiang Cuiping , Tao Xiaoming , Sun Jiao 
Published: November 2022

Abstract
Background
Vemurafenib (VEM) is a commonly used inhibitor of papillary thyroid cancer (PTC) and melanoma with the BRAFV600E mutation; however, acquired resistance is unavoidable. The present study aimed to identify a potential target to reverse resistance.

Materials and methods
A VEM-resistant PTC cell line (B-CPAP/VR) was established by gradually increasing the drug concentration, and a VEM-resistant BRAFV600E melanoma cell line (A375/VR) was also established. RNA sequencing and bioinformatics analyses were conducted to identify dysregulated genes and construct a transcription factor (TF) network. The role of a potential TF, forkhead box P2 (FOXP2), verified by qRT-PCR, was selected for further confirmation.

Results
The two resistant cell lines were tolerant of VEM and displayed higher migration and colony formation abilities (p < 0.05). RNA sequencing identified 9177 dysregulated genes in the resistant cell lines, and a TF network consisting of 13 TFs and 44 target genes was constructed. Alterations in FOXP2 expression were determined to be consistent between the two VEM-resistant cell lines. Finally, silencing FOXP2 resulted in an increase in drug sensitivity and significant suppression of the migration and colony formation abilities of the two resistant cell lines (p < 0.05).

Conclusions
The present study successfully established two VEM-resistant cell lines and identified a potential target for VEM-resistant PTC or melanoma.
ORIHIME study: real-world treatment patterns and clinical outcomes of 338 patients with acquired hemophilia A from a Japanese administrative database
Authors: Ogawa Yoshiyuki , Amano Kagehiro , Matsuo-Tezuka Yukari , Okada Norihiro , Murakami Yoichi , Nakamura Takao , Yamaguchi-Suita Haruko , Nogami Keiji 
Published: November 2022

Abstract
Background
Acquired hemophilia A (AHA) is a rare disorder, and clinical practices for treating AHA have not been fully clarified in Japan.

Objectives
This study aims to investigate the epidemiology of AHA and real-world treatment practices in Japan.

Patients/methods
This observational study was based on a health administrative database of hospitalized patients diagnosed with AHA who were treated with immunosuppressants.

Results
The study included 214 males and 124 females (mean age 75.7 years). The most frequently used bypassing agent was recombinant activated factor VII. The predominant choice of immunosuppressant for first-line treatment was steroid monotherapy. Median days from the index date to the start of rehabilitation was 65.0 for cardiovascular, 35.5 for respiratory and 23.0 for locomotor. The proportion of patients with an activities of daily living (ADL) score < 70 points was high at both first admission and final discharge (47.4% and 38.8%). The percentage of deaths during hospitalization was 18.6%.

Conclusions
This study clarified the treatment patterns and clinical outcomes of AHA in a large population in Japan. This was the first study showing ADL score distribution and time to rehabilitation. Further investigation is needed to develop better clinical practices for treatment of AHA.
A new approach to use of wavelet transform for baseflow separation of Karst springs (case study: Gamasiyab spring)
Authors: Solgi Abazar , Zarei Heidar , Marofi Safar 
Published: November 2022

AbstractToday, groundwater is the essential resource the whole water sector demands. The spring baseflow discharge analysis can significantly help us better manage water resources. This study was focused on the separation baseflow discharge of the Gamasiyab karstic spring (western Iran) using the wavelet transform (WT). The recursive digital filter (RDF) method with different algorithms has been used to compare the approach performance. Forty-nine years (1968–2018) of the recorded springs’ daily discharge data were used for this aim. The isotopic content (IC) method was used to determine the best RDF algorithm and WT for baseflow separation. The IC of the monthly samples taken in 2017–2018 was measured. The results showed that the WT had the adjusted coefficient of determination ($$R_{{{\text{adjusted}}}}^{2}$$

R

adjusted

2

) of 0.95 and root mean square error (RMSE) of 0.552 (m3/s) compared to the IC index method. The best algorithm in the RDF method was related to the Eckhardt algorithm with $$R_{{{\text{adjusted}}}}^{2}$$

R

adjusted

2

of 0.97 and RMSE of 0.670 (m3/s), which had the best performance compared to the IC index method. Results showed that in most samples, the values of the separated baseflow by the WT are closer to the isotopic values. Also, based on the RMSE criterion, the WT has a lower RMSE than the RDF method and is known as the best method in this study. The results showed that the WT accurately separated the spring baseflow discharge and could split the baseflow of rivers.
A Depth Sensor Based on Transient Property of Liquid Crystal Lens
Authors: Xiao Haifeng , Liu Zhiqiang , Tan Baolin , Ye Mao 
Published: November 2022

AbstractThe property of maintaining the lens state of the liquid crystal (LC) lens during the switching between positive and negative lens states is made use of in the fast acquirement of multi-focus images without magnification change. A depth from focus (DFF) pipeline that can generate a low-error depth map and an all-in-focus image is proposed. The depth of the scene is then obtained via DFF pipeline from the captured images. The depth sensor proposed in this paper has the advantages of simple structure, low cost, and long service life.
Product gas biomethanation with inoculum enrichment and grinding
Authors: Hu Xiao , Jiang Bingyi , Yu Chunjiang , Söderlind Ulf , Göransson Kristina , Zhang Wennan 
Published: November 2022

AbstractThe use of cheap product gas from biomass air gasification to produce methane via anaerobic digestion is a novel and potential pathway for the large-scale production of biomass-based substitute natural gas (BioSNG). In this experimental work, the product gas biomethanation (PGB) was studied with respect to the biosludge enrichment and inoculum partial grinding as well as the mesophilic and thermophilic conditions. The results show that the biosludge enrichment can effectively stop methanogenesis inhibition from the product gas, particularly CO, thus increase the biomethanation reaction rate and shorten the reaction start-up time. The inoculum partial grinding treatment can clearly change the microorganism composition and effectively reduce the diversity of microorganisms in the mixed bacterium system for the mesophilic biomethanation, thereby improving the product gas biomethanation efficiency, which is limited for the thermophilic biomethanation.
Die MISSCARE-Austria-Studie – Teil II
Authors: Cartaxo Ana , Eberl Inge , Mayer Hanna 
Published: November 2022

Zusammenfassung
Hintergrund
Eine sichere und qualitativ angemessene Versorgung im Krankenhaus erfordert den Einsatz einer adäquaten, den Bedarfen von Patient*innen und ihrer Angehörigen entsprechenden Anzahl an qualifizierten Pflegepersonen. Für Allgemeinstationen in österreichischen Krankenhäusern gibt es hierzu keine explizite Orientierung. Die Datenlage zum Pflegepersonaleinsatz auf Allgemeinstationen und dessen Angemessenheit ist hierzulande limitiert. Diese beiden Faktoren dienen als Prädiktoren für das Weglassen pflegerischer Versorgung – Missed Nursing Care (MNC).

Ziele
Eine erste Datenlage zum Einsatz von Pflegepersonalressourcen auf Allgemeinstationen in österreichischen Krankenhäusern mittels Patient-to-Nurse Ratio (PtN) vorzustellen; die Einschätzung der Angemessenheit der Pflegepersonalbesetzung aus Sicht von Pflegepersonen zu erheben und den Einfluss beider Variablen auf MNC zu diskutieren.

Methode
Es wurde eine quantitative Querschnittstudie mit dem Revised-MISSCARE-Austria-Instrument zwischen Mai und Juli 2021 durchgeführt. Zielgruppe waren Pflegepersonen, die in diesem Zeitraum auf Allgemeinstationen in österreichischen Krankenhäusern in der direkten Patient*innenversorgung tätig waren. Die Datenanalyse erfolgte mittels deskriptiver Statistik sowie Korrelationskoeffizienten, nichtparametrischen Gruppenvergleichstests und univariater multifaktoriellen Varianzanalyse.

Ergebnisse
In der Datenanalyse wurden 846 Fälle berücksichtigt. PtN-Werte auf konservativen und/oder operativen Allgemeinstationen in österreichischen Krankenhäusern situieren sich im internationalen Vergleich in einem hohen Bereich: Durchschnittlich werden ca. 15 Patient*innen/Pflegeperson am Tag- bzw. 22 Patient*innen/Pflegeperson im Nachtdienst versorgt. Unterschiede nach Krankenhauslokalisation und -größe sowie nach Berufsgruppe in der Pflege zeigen sich statistisch signifikant. 67,8% der Befragten geben an, dass die Pflegepersonalbesetzung in den letzten 3 Monaten selten oder nie angemessen war. Beide Variablen zeigen einen statistisch signifikanten Einfluss auf MNC.

Schlussfolgerung
Entsprechend dieser Ergebnisse zeigt sich eindeutig die Notwendigkeit der Einführung eines Monitorings zur aktuellen Pflegepersonalsituation auf Allgemeinstationen in österreichischen Krankenhäusern. Hier erscheint nicht nur die PtN, sondern auch die Einschätzung der Angemessenheit der Pflegepersonalbesetzung aus Sicht von Pflegepersonen für die Beurteilung der Pflegepersonalsituation relevant.
Thiamine Deficiency in the Pathophysiology and Diagnosis of Wernicke-Korsakoff Syndrome: Case Report and Literature Review
Authors: De Lorenzo Chiara , Martocchia Antonio , Fedele Elena , Di Gioia Valeria , Gagliardo Olga , Martelletti Paolo ,   Emergency Unit of S. Andrea Hospital
Published: November 2022

AbstractThiamine deficiency is associated with life-threatening pathologies, as Wernicke syndrome (WS), Korsakoff syndrome (KS), Marchiafava-Bignami (MB) disease, and wet or dry beri-beri (BB). Among the etiological factors, the thiamine deficiency may be suspected in subjects at risk for malnutrition (decreased nutrient intake, increased nutrient losses, or impaired nutrient absorption). Computed tomography (CT) but especially magnetic resonance imaging (MRI) is the best method to detect diencephalic and mesencephalic cytotoxic edematous lesions in patients with acute WS, with hyperintense on long-TR spin-echo MRI imaging and low-density signal abnormalities on CT scans. We report a case of WS in an 82-year-old woman with the history of cancer and eating disorder, who presented a neurological worsening during recovery, associated with low serum thiamine levels and the presence of symmetrical areas of hyperintense signal in the long-TR sequences of MRI. After parenteral thiamine supplementation, we observed a rapid improvement of ocular and language disorders occurred, with a low and incomplete improvement of peripheral neuropathy, supporting the WS diagnosis. Our case report presented the clinical picture of WS and KS and the diagnosis was confirmed by both the laboratory tests and the brain imaging techniques. The dosage of the vitamin was useful and accurate when performed before the beginning of the supplementation therapy. This case is important in bringing to light a clinical picture often observed in many medical recovery units.
Spatio-temporal patterns of the European wildcat in a Mediterranean coastal area
Authors: Ferretti Francesco , Lazzeri Lorenzo , Sforzi Andrea 
Published: November 2022

AbstractLike most small felids, the European wildcat Felis silvestris is a rather elusive species, poorly detectable in the wild, due to several aspects of its biology. Camera trapping can represent a suitable tool to understand temporal activity patterns and habitat preferences of such elusive species. We used intensive camera trapping over two full years to investigate spatio-temporal patterns of the wildcat in a Mediterranean coastal protected area (Maremma Regional Park, central Italy). At the seasonal scale, the wildcat showed a marked twilight activity in summer and winter (mating period), and nocturnal activity in autumn. Conversely, a peak of activity during the day, i.e., in broad daylight, was reported in spring. Reproductive females may limit their nocturnal movements in spring to increase protection from predators to their kittens at the den, although further data are required to support this conclusion. At seasonal, semestral, and yearly temporal scales, the frequency of wildcat detections increased along with availability of shrubwood. These results emphasise the importance for this small felid of areas with dense vegetation cover (Mediterranean maquis and shrubwood, in our study area). Areas densely covered with shrubby vegetation are expected to provide benefits to this elusive small cat in terms of reduced human disturbance (included tourists), availability of prey (e.g., small mammals), as well as shelter, essential to ensure protection towards potential larger predators.
Jane Austen and Other Minds
Authors: Lindstrom Eric Reid 
Published: November 2022

Jane Austen's fiction is itself philosophy, a fact to which Stanley Cavell attested when he honored his philosophical teacher, J. L. Austin, through homage to her and her work. Engaging equally in criticism and in philosophy, Jane Austen and Other Minds demonstrates the standing of Austen's fiction as a philosophical investigation, both in its own right and as a resource to ordinary language philosophy in the twentieth and twenty-first centuries. Eric Reid Lindstrom addresses a long-standing shortcoming of Austen scholarship by locating in her fiction a linguistic phenomenology available to the novelistic everyday but not afforded her in intellectual history. He simultaneously advances recognition and understanding of J. L. Austin and Stanley Cavell, and of ordinary language philosophy, within Austen scholarship and the broader field of contemporary literary studies. This book argues compellingly for Cavell's choice of Austen as a means to pursue 'passionate exchange,' reimagining her common association with restriction and confinement.
But does the nudge fit? Institutional structure and behavioural insights
Authors: Merrick Weston 
Published: November 2022

AbstractBehavioural science has found growing application in applied public policy settings, offering a vast literature to bring to bear on apparent cognitive errors. The potential, however, is not without peril. Policymakers and scholars may draw unwarranted confidence that successful behavioural interventions from elsewhere will replicate in their institutional settings. In this research, I partner with Minneapolis Public Housing and use a design-based approach to identify interventions that can reduce eviction actions. This study presents three vignettes that demonstrate and categorize the mistakes behavioural science can make when it fails to understand how formal and informal institutional features influence decision-making. But, in integrating methods and theories from the design sciences, public policy and public administration, we have the potential to create behavioural interventions that fit the social context.