bluuebunny/crossref_metadata_2025_split huggingface dataset:
Drug resistance in cancer therapy: the Pandora's Box of cancer stem cells
Authors: Rezayatmand Hamed , Razmkhah Mahboobeh , Razeghian-Jahromi Iman 
Published: May 2022

AbstractDrug resistance is the main culprit of failure in cancer therapy that may lead to cancer relapse. This resistance mostly originates from rare, but impactful presence of cancer stem cells (CSCs). Ability to self-renewal and differentiation into heterogeneous cancer cells, and harboring morphologically and phenotypically distinct cells are prominent features of CSCs. Also, CSCs substantially contribute to metastatic dissemination. They possess several mechanisms that help them to survive even after exposure to chemotherapy drugs. Although chemotherapy is able to destroy the bulk of tumor cells, CSCs are left almost intact, and make tumor entity resistant to treatment. Eradication of a tumor mass needs complete removal of tumor cells as well as CSCs. Therefore, it is important to elucidate key features underlying drug resistance raised by CSCs in order to apply effective treatment strategies. However, the challenging point that threatens safety and specificity of chemotherapy is the common characteristics between CSCs and normal peers such as signaling pathways and markers. In the present study, we tried to present a comprehensive appraisal on CSCs, mechanisms of their drug resistance, and recent therapeutic methods targeting this type of noxious cells.
Studies on human body composition in Russia: past and present
Authors: Rudnev Sergey G. , Godina Elena Z. 
Published: May 2022

AbstractDespite the presence of body composition studies in Russia, there are no current reviews on this topic, and the results are relatively rarely published abroad. Our aim was to describe the history and current state of this research work, to list unresolved problems, and to outline possible developmental trends. For completeness, in the initial part of the review, traditional research areas indirectly related to body composition studies are considered, namely, the analysis of biological variation of anthropometric parameters and somatotyping.It can be seen that anthropometry and bioimpedance analysis (BIA) are mainly used to assess body composition in Russia. Other methods, such as double-energy X-ray absorptiometry (DXA), are utilized less often. The achievements include the common use of comprehensive anthropometry in anthropological studies, some advancements in clinical studies, approbation of potentially important methods such as the deuterium dilution method and three-dimensional laser-based photonic scanning, and ongoing mass population BIA measurements in health centers. Various bioimpedance instruments are manufactured, the local reference BIA body composition data are available, and a large updated BIA database is ready for international comparisons.Among major limitations of body composition research in Russia, one can note the lack of validation studies using reference methods, so that foreign regression formulas are used with the double indirect methods, such as anthropometry and BIA, despite the fact that their accuracy has not yet been checked in our population. Conventional reference body composition assessment methods, such as three- or four-component molecular-level models and whole-body in vivo neutron activation analysis, were not applied yet, despite the technical feasibility.In general, it can be argued that the body composition research in Russia follows the observed global trends. Along with the achievements, there are a number of unresolved methodological and organizational issues. Prospects for further research include validation studies, updating reference population body composition data, and establishing local cut-offs for malnutrition and disease risks. In our view, further development could be facilitated with the establishment of well-equipped Human Body Composition Units in major Russian research centers, such as Moscow State University, which could be
assigned a coordinating and methodical role.
A systematic review and research perspective on recommender systems
Authors: Roy Deepjyoti , Dutta Mala 
Published: May 2022

AbstractRecommender systems are efficient tools for filtering online information, which is widespread owing to the changing habits of computer users, personalization trends, and emerging access to the internet. Even though the recent recommender systems are eminent in giving precise recommendations, they suffer from various limitations and challenges like scalability, cold-start, sparsity, etc. Due to the existence of various techniques, the selection of techniques becomes a complex work while building application-focused recommender systems. In addition, each technique comes with its own set of features, advantages and disadvantages which raises even more questions, which should be addressed. This paper aims to undergo a systematic review on various recent contributions in the domain of recommender systems, focusing on diverse applications like books, movies, products, etc. Initially, the various applications of each recommender system are analysed. Then, the algorithmic analysis on various recommender systems is performed and a taxonomy is framed that accounts for various components required for developing an effective recommender system. In addition, the datasets gathered, simulation platform, and performance metrics focused on each contribution are evaluated and noted. Finally, this review provides a much-needed overview of the current state of research in this field and points out the existing gaps and challenges to help posterity in developing an efficient recommender system.
Infra-tentorial brain tumor subtypes in children and adults—surgical outcome in an ethnic population with a single regional tertiary center
Authors: Bhat Abdul Rashid , Wani Muhammed Afzal , Kirmani Altaf Rehman 
Published: May 2022

Abstract
Background
To analyze clinically and radiologically the surgical outcome like residual disease, progression of disease, recurrence, disabilities, event-free survival (EFS), and mortality of different infra-tentorial tumor subtypes in children and adults of a strictly non-migratory and ethnic population.

Methods
The 410 histologically proved, out of 589, infra-tentorial brain tumor patients were analyzed clinically and by the imaging post-surgically in a single tertiary center for an ethnic region. In this analytico-observational study, retrospectively postoperative records of 589 infra-tentorial brain tumors from November 1998 to December 2018 (20 years) were retrieved, scrutinized, and compiled. The post-operative clinic-radiological records of 410 patients with proved histopathological examination results were included. Statistical law of variance was applied where-ever necessary.

Results
The 63.2% of the all 410 operated infra-tentorial brain tumors were males while females predominated in meningiomas and pineoblastomas. About 31.7% infra-tentorial tumors were children (below 18 years). About 54.1% cases were histologically malignant. The residual tumors comprised 40.2% and symptoms of disease-progression occurred in 10.9%. The tumor recurrence occurred in 14.3% while 6.0% patients developed severe disability. The overall mortality was 11.4% but 18.9% in malignant tumors. The event-free survival (EFS) for all the patients was 66.0%, patients with malignancies had 47.7% and benign group had 87.7%.

Conclusion
The study, surgical outcome of infra-tentorial brain tumor subtypes in children and adults (approx. 1/3rd of patients being children), conducted in a tertiary center at a remote land-locked location with non-migratory ethnic population as its catchment area, has a significant epidemiological value for the community and the region.
Internal electrical fault detection techniques in DFIG-based wind turbines: a review
Authors: Bebars Abdelwahab D. , Eladl Abdelfattah A. , Abdulsalam Gabr M. , Badran Ebrahim A. 
Published: May 2022

AbstractThe keys factor in making wind power one of the main power sources to meet the world's growing energy demands is the reliability improvement of wind turbines (WTs). However, the eventuality of fault occurrence on WT components cannot be avoided, especially for doubly-fed induction generator (DFIG) based WTs, which are operating in severe environments. The maintenance need increases due to unexpected faults, which in turn leads to higher operating cost and poor reliability. Extensive investigation into DFIG internal fault detection techniques has been carried out in the last decade. This paper presents a detailed review of these techniques. It discusses the methods that can be used to detect internal electrical faults in a DFIG stator, rotor, or both. A novel sorting technique is presented which takes into consideration different parameters such as fault location, detection technique, and DFIG modelling. The main mathematical representation used to detect these faults is presented to allow an easier and faster understanding of each method. In addition, a comparison is carried out in every section to illustrate the main differences, advantages, and disadvantages of every method and/or model. Some real monitoring systems available in the market are presented. Finally, recommendations for the challenges, future work, and main gaps in the field of internal faults in a DFIG are presented. This review is organized in a tutorial manner, to be an effective guide for future research for enhancing the reliability of DFIG-based WTs.
Factors associated with hospitalizations for Covid-19 in patients with rheumatoid arthritis: data from the Reumacov Brazil registry
Authors: Gomides Ana Paula Monteiro , de Albuquerque Cleandro Pires , da Mota Licia Maria Henrique , Devidé Guilherme , Dias Laiza Hombre , Duarte Angela Luzia Branco Pinto , Giovelli Raquel Altoé , Karnopp Thais Evelyn , de Lima Hugo Deleon , Marinho Adriana , de Oliveira Marianne Schrader , Omura Felipe , Ranzolin Aline , Resende Gustavo , Ribeiro Francinne Machado , Ribeiro Sandra Lúcia Euzébio , de Carvalho Sacilotto Nathália , dos Santos Wander Gonzaga , Shinjo Samuel Katsuyuki , de Sousa Studart Samia Araujo , Teixeira Flávia Patricia Sena , Yazbek Michel Alexandre , Ferreira Gilda Aparecida , Monticielo Odirlei A. , Paiva Eduardo , Pileggi Gecilmara Cristina Salviato , dos Reis-Neto Edgard Torres , de Medeiros Pinheiro Marcelo , Marques Claudia D. L. ,   On behalf of ReumaCoV Brasil Registry
Published: May 2022

Abstract
Background
Patients using immunosuppressive drugs may have unfavorable results after infections. However, there is a lack of information regarding COVID-19 in these patients, especially in patients with rheumatoid arthritis (RA). Therefore, the aim of this study was to evaluate the risk factors associated with COVID-19 hospitalizations in patients with RA.

Methods
This multicenter, prospective cohort study is within the ReumaCoV Brazil registry and included 489 patients with RA. In this context, 269 patients who tested positive for COVID-19 were compared to 220 patients who tested negative for COVID-19 (control group). All patient data were collected from the Research Electronic Data Capture database.

Results
The participants were predominantly female (90.6%) with a mean age of 53 ± 12 years. Of the patients with COVID-19, 54 (20.1%) required hospitalization. After multiple adjustments, the final regression model showed that heart disease (OR = 4.61, 95% CI 1.06–20.02. P < 0.001) and current use of glucocorticoids (OR = 20.66, 95% CI 3.09–138. P < 0.002) were the risk factors associated with hospitalization. In addition, anosmia was associated with a lower chance of hospitalization (OR = 0.26; 95% CI 0.10–0.67, P < 0.005).

Conclusion
Our results demonstrated that heart disease and the use of glucocorticoids were associated with a higher number of hospital admissions for COVID-19 in patients with RA.
Trial registration: Brazilian Registry of Clinical Trials - RBR-33YTQC.
Non-traditional roles of immune cells in regeneration: an evolutionary perspective
Authors: Arinda Beryl N. , Innabi Yacoub A. , Grasis Juris A. , Oviedo Néstor J. 
Published: May 2022

ABSTRACT
Immune cells are known to engage in pathogen defense. However, emerging research has revealed additional roles for immune cells, which are independent of their function in the immune response. Here, we underscore the ability of cells outside of the adaptive immune system to respond to recurring infections through the lens of evolution and cellular memory. With this in mind, we then discuss the bidirectional crosstalk between the immune cells and stem cells and present examples where these interactions regulate tissue repair and regeneration. We conclude by suggesting that comprehensive analyses of the immune system may enable biomedical applications in stem cell biology and regenerative medicine.
The origins and roles of osteoclasts in bone development, homeostasis and repair
Authors: Yahara Yasuhito , Nguyen Tuyet , Ishikawa Koji , Kamei Katsuhiko , Alman Benjamin A. 
Published: May 2022

ABSTRACT
The mechanisms underlying bone development, repair and regeneration are reliant on the interplay and communication between osteoclasts and other surrounding cells. Osteoclasts are multinucleated monocyte lineage cells with resorptive abilities, forming the bone marrow cavity during development. This marrow cavity, essential to hematopoiesis and osteoclast-osteoblast interactions, provides a setting to investigate the origin of osteoclasts and their multi-faceted roles. This Review examines recent developments in the embryonic understanding of osteoclast origin, as well as interactions within the immune environment to regulate normal and pathological bone development, homeostasis and repair.
Immune cell-stem cell interactions in regeneration and repair: who's calling the shots?
Authors: Samperio Ventayol Pilar , Bartfeld Sina 
Published: May 2022

ABSTRACT
In November 2021, the Institute for Regenerative Medicine (IRM) and the Institute for Immunology (IFI) at the University of Pennsylvania, USA, joined forces and organized a symposium featuring external speakers as well as locally based scientists to discuss how the immune system influences tissue stem cell biology. As we review here, the presentations highlighted emerging concepts in the field, revealing how tissue-specific immune cell activation can guide stem cells in regeneration and repair.
Biology of resident tissue macrophages
Authors: Lee Christopher Zhe Wei , Ginhoux Florent 
Published: May 2022

ABSTRACT
Although best known for their phagocytic and immunological functions, macrophages have increasingly been recognised as key players in the development, homeostasis and regeneration of their host tissues. Early during development, macrophages infiltrate and colonise all tissues within the body, developing symbiotically with their host tissues and acquiring unique functional adaptations based on the tissue microenvironment. These embryonic resident tissue macrophages (RTMs) are ontogenically distinct from the later adult bone marrow-derived monocytes, and in some tissues are self-maintained independently of general circulation at a steady state. In this article, we briefly discuss the ontogeny, maintenance and unique tissue adaptions of RTMs focusing on microglia, Kupffer cells, Langerhans cells, intestinal macrophages, cardiac macrophages and tumour-associated macrophages, and highlight their role in development, homeostasis and dysfunction.
Phytochrome-interacting factors orchestrate hypocotyl adventitious root initiation inArabidopsis
Authors: Li Qian-Qian , Zhang Zhan , Zhang Chao-Xing , Wang Ya-Ling , Liu Chu-Bin , Wu Jia-Chen , Han Mei-Ling , Wang Qiu-Xia , Chao Dai-Yin 
Published: May 2022

ABSTRACTAdventitious roots (ARs) are an important type of plant root and display high phenotypic plasticity in response to different environmental stimuli. It is known that photoreceptors inhibit darkness-induced hypocotyl adventitious root (HAR) formation by directly stabilizing Aux/IAA proteins. In this study, we further report that phytochrome-interacting factors (PIFs) plays a central role in HAR initiation by simultaneously inducing the expression of genes involved in auxin biosynthesis, auxin transport and the transcriptional control of root primordium initiation. We found that, on the basis of their activity downstream of phytochrome, PIFs are required for darkness-induced HAR formation. Specifically, PIFs directly bind to the promoters of some genes involved in root formation, including auxin biosynthesis genes YUCCA2 (YUC2) and YUC6, the auxin influx carrier genes AUX1 and LAX3, and the transcription factors WOX5/7 and LBD16/29, to activate their expression. These findings reveal a previously uncharacterized transcriptional regulatory network underlying HAR formation.
Sexual and reproductive health and rights knowledge, perceptions, and experiences of adolescent learners from three South African townships: qualitative findings from the Girls Achieve Power (GAP Year) Trial
Authors: Pleaner Melanie , Milford Cecilia , Kutywayo Alison , Naidoo Nicolette , Mullick Saiqa 
Published: May 2022

Background: Adolescence is a time of psycho-social and physiological changes, with increased associated health risks including vulnerability to pregnancy, HIV, sexually transmitted infections, and gender-based violence. Adolescent learners, from three townships in South Africa, participated in a 44 session, after-school asset-building intervention (GAP Year), over 2 years providing sexual and reproductive health (SRH) education. This paper explores adolescent learners’ SRH, sexual risk and rights knowledge; perceptions about transactional sex; and contraceptive method preferences and decision-making practices. Methods: The intervention was conducted in 13 secondary schools across Khayelitsha, Thembisa, and Soweto, South Africa. A baseline survey collected socio-demographic data prior to the intervention. Overall, 26 focus group discussions (FGDs): 13 male and 13 female learner groups, purposively selected from schools, after the intervention (2 years after baseline data collection). Descriptive analyses were conducted on baseline data. Qualitative data were thematically coded, and NVivo was used for data analysis. Results: In total, 194 learners participated in the FGDs. Mean age at baseline was 13.7 years (standard deviation 0.91). Participants acquired SRH and rights knowledge during the GAP Year intervention. Although transactional sex was viewed as risky, some relationships were deemed beneficial and necessary for material gain. Negative healthcare provider attitudes were the main barrier to healthcare service utilisation. There was awareness about the benefits of contraceptives, but some myths about method use. The injectable was the preferred contraceptive method, followed by the implant, with equal preference for condoms and oral pill. Conclusions: An afterschool intervention at school is a viable model for the provision of SRH and rights education to learners. Recommendations include the need for risk reduction strategies in the curriculum, dealing with misconceptions, and the promotion of informed decision making. Endeavours to ensure health services are youth friendly is a priority to limit barriers to accessing these services.
Leveraging innovative technologies for designing a healthy and personalized breakfast: consumer perception of three smart cooking devices in the EU
Authors: Talens Clara , Rios Yolanda , Santa Cruz Elena 
Published: May 2022

Background: Rapid demographic growth and global population ageing will have profound impacts on food and nutrition. In the long run, the smart appliance industry will reflect the social, technological, and demographic forces around food consumption. This study aims to provide valuable consumer insights about smart home cooking devices for a healthy and personalised breakfast. Methods: Three smart cooking technologies (3D food printing, digital sous-vide cooking and instant dough baking), one ingredient supplier, and a food research centre shared resources to carry out common tasks such as market research and consumer validation tests. Consumers were segmented into four types of households (single, young or consolidated families and senior). An online community (40 participants), nine focus groups, two interviews (8 experts), and one quantitative study (2055 participants) were carried out in Spain, UK, and Germany. Results: Consumer perception of three smart cooking devices in the EU has been explored in-depth. Insights have shown the potential of innovative technologies for designing a healthy and personalised breakfast. A customized, fresh, tasty, nutritious, and healthy 3D printed breakfast bar was developed for senior consumers by using the smart cooking devices. A tasting session with 80 senior Spanish consumers, aged 45 to 75 years, showed that around 56% of consumers increased their acceptance of the new breakfast bar after being informed about its technological, nutritional, and convenient benefits. Conclusions: The findings provided both theoretical and practical insights into the perception of the three smart cooking devices, per type of household and per country. A combination of technologies was used to develop the new breakfast concept for the target group and country with the most positive perception. This study shows how to share resources for gathering information on product attributes, consumer experience, and for validating the new concept with the target group identified via consumer market research.
Reconfigurable photoinduced terahertz wave modulation using hybrid metal–silicon metasurface
Authors: Ullah Ahasan , Wang Yi-Chieh , Yeasmin Sanjida , Deng Yijing , Ren Jun , Shi Yu , Liu Lei , Cheng Li-Jing 
Published: May 2022

We present a photoinduced reconfigurable metasurface to enable high spatial resolution terahertz (THz) wave modulation. Conventional photoinduced THz wave modulation uses optically induced conductive patterns on a semiconductor substrate to create programmable passive THz devices. The technique, albeit versatile and straightforward, suffers from limited performance resulting from the severe lateral diffusion of the photogenerated carriers that undermines the spatial resolution and conductivity contrast of the photoinduced conductive patterns. The proposed metasurface overcomes the limitation using a metal-jointed silicon mesa array with subwavelength-scaled dimensions on an insulator substrate. The structure physically restrains the lateral diffusion of the photogenerated carriers while ensuring the electrical conductivity between the silicon mesas , which is essential for THz wave modulation. The metasurface creates high-definition photoconductive patterns with dimensions smaller than the diffusion length of photogenerated carriers. The metasurface provides a modulation depth of −20 to −10 dB for the THz waves between 0.2 to 1.2 THz and supports a THz bandpass filter with a tunable central frequency. The new, to the best of our knowledge, design concept will benefit the implementation of reconfigurable THz devices.