bluuebunny/crossref_metadata_2025_split huggingface dataset:
Perfusion parameters predict pathology and mutation status in lung cancer brain metastases based on CT imaging: a pilot study
Authors: Jiang Chuncheng , Liu Xin , Qu Qianqian , Jiang Zhonghua , Wang Yunqiang 
Published: December 2022

Abstract
Objectives
To define the pathological subtype and mutational status of metastatic disease in patients with non-small cell lung cancer (NSCLC) using CT imaging-based perfusion parameters analysis of brain metastatic lesions.
Methods
We retrospectively identified NSCLC patients with brain metastases who got treatment in our hospital during 2019 to 2021 and had their underlying lung cancer pathologically and genotypically tested. CT perfusion images of the brain were utilized to segment enhancing tumors and peritumoral edema, as well as extract CT perfusion parameters. The most relevant perfusion parameters were identified to classify the pathological subtype and mutation status. Squamous cell carcinoma was found in 15 of the 45 patients in the research cohort (mean age 66.29 ± 9.98 years; M: F = 26:19), while adenocarcinoma was found in 30. In addition, 19 had an epidermal growth factor receptor (EGFR) mutation, and 11 had an EGFR wild-type. After admission, all patients were subjected to a CT perfusion imaging examination. The differences in CT perfusion parameters between different pathological subtypes and mutational status were analyzed. The receiver-operating characteristic (ROC) curve was used to predict the pathological subtype and mutational status of the metastasis.
Results
Among the quantitative parameters, CBF and MTT were significantly different between the two lung cancers, as well as the two mutational statuses (adenocarcinoma vs. squamous cell carcinoma: P < 0.001, P < 0.001.EGFR mutation vs. EGFR wild-type: P < 0.016, P < 0.046.). For classification of pathological subtype, EGFR mutation status, the model developed with both CBF and MTT resulted in area-under-the-curve (AUC) values of 0.849 and 0.790, respectively.
Conclusions
Perfusion parameters analysis of brain metastases using CT imaging in patients with primary lung cancer could be used to classify pathological subtype and mutational status. This method might be beneficial for developing treatment plans and determining prognosis.
In silico analysis of NHP2 membrane protein, a novel vaccine candidate present in the RD7 region of Mycobacterium tuberculosis
Authors: Kootery Kaviya Parambath , Sarojini Suma 
Published: December 2022

Abstract
Mycobacterium tuberculosis, the etiological agent of tuberculosis, is one of the most tricky pathogens. We have only a few protective shields, like the BCG vaccine against the pathogen, which itself has poor efficacy in preventing adult tuberculosis. Even though different vaccine trials for an alternative vaccine have been conducted, those studies have not shown much promising results. In the current study, advanced computational technology was used to study the potential of a novel hypothetical mycobacterial protein, identified by subtractive hybridization, to be a vaccine candidate. NHP2 (Novel Hypothetical Protein 2), housed in the RD7 region of the clinical strains of M. tuberculosis, was studied for its physical, chemical, immunological and structural properties using different computational tools. PFAM studies and Gene ontology studies depicted NHP2 protein to be functionally active with a possible antibiotic binding domain too. Different computational tools used to assess the toxicity, allergenicity and antigenicity of the protein indicated its antigenic nature. Immune Epitope Database (IEDB) tools were used to study the T and B cell determinants of the protein. The 3D structure of the protein was designed, refined and authenticated using bioinformatics tools. The validated tertiary structure of the protein was docked against the TLR3 immune receptor to study the binding affinity and docking scores. Molecular dynamic simulation of the protein-protein complex formed were studied. NHP2 was found to activate host immune response against tubercle bacillus and could be explored as a potential vaccine in the fight against tuberculosis.
Assessment of Farmers’ Perception on Potato Farming Systems
Authors: Momina  , Tesfaye  , Wallelign  , Tadele  
Published: December 2022

Abstract
Assessment of farmers’ perception on potato farming systems was carried out with the main objective of investigating the perception of farmers’ on potato (Solanum tuberosum L.) in the farming systems in north western Ethiopia. Secondary and primary sources of data were collected. 9.8% farmers went through off farm activities. They had an average potato production experience, livestock number and farm size of 36.81 years, 5.17 and 1.63ha, respectively. These farmers allot on average 0.47 ha (28.83%) of their land for potato production. The dominant potato growing season was the main season (65.1%), followed by irrigation season (25.7%) and with residual moisture (9.2%). 16.6% produced potato used as seed, 48.55% for household consumption and 25.73% sold in the near bye market with very low price (2.17 Birr/kg) as income source. On average there were two commonly grown varieties per farmer. They were losing such local potato varieties which had different quality attributes to be used in different breeding/agronomy programmes and best fit to degraded lands. Farmers ploughed their land 3.34 times before planting potato and used 2.13 t/ha potato seeds at planting as seed rate. 14.4% used their own seeds, 73.5% purchased from the surrounding market, 10.2% from their neighbors and 1.9% from the agricultural offices. Most farmers (63.0%) used fertilization, crop rotation mainly with potato (35.1%) and terracing technique (1.9%) as traditional technique of soil fertility management. Generally, farmers in the surveyed area believed that potato can ameliorate the soil fertility and protect their soils from erosion. Researches should be conducted to minimize number of ploughing in potato production. NGO’s, GOs and universities should take responsibilities to multiply and disseminate improved potato seeds and in the conservation of important local varieties. Trainings should also be given to farmers on production and usage of certified potato seeds on potato production.
The regenerative role of mast cells and mesenchymal stem cells in histopathology of sciatic nerve and tibialis cranialis muscle, following denervation in rats
Authors: Bakhtiary Zahra , Shahrooz Rasoul , Hobbenaghi Rahim , Azizi Saeed , Soltanalinejad Farhad , Khoshfetrat Ali Baradar 
Published: December 2022

Abstract
Atrophy of the leg muscles following sciatic nerve transection can lead to the death of myofibers. The aim of this study was to evaluate the process of nerve and muscle regeneration using mast cells and mesenchymal stem cells.
In this study, 90 adult male Wistar rats weighing 150-200g were randomly divided into six main groups (n=15) and each group into three subgroups (2, 4 and 8 weeks, n=5). Groups: control; without surgery, transection (Tr); Fixing the two ends of the transected sciatic nerve (8 mm gap) in silicone tube, scaffold (S); Put collagen gel inside the silicone tube, mast cell (MC); Placed 3×104 mast cells mixed with scaffold, mesenchymal stem cell (MSC); Placed 3×104 mesenchymal stem cells mixed with scaffold, and mast cell-mesenchymal stem cell (MC+MSC); 3×104 of each of the mast cell and mesenchymal stem cells along with scaffold. Animals euthanized and sampled at weeks 2, 4 and 8 for muscle and nerve histological and nerve immunohistochemistical evaluations.
Histomorphometric evaluation results of tibialis cranialis muscle (TCM) included: diameter of muscle fibers, ratio of the muscle fiber’s nuclei to the fibrocyte nuclei (mn/fn), ratio of the muscle fibers nuclei number to the muscle fiber’s number (mn/mf) and ratio of the blood vessels number to the number of muscle fibers (v/mf) in all treatment groups, especially the MC + MSC group, increased compared to the Tr group but the number of mast cells, the percentage of sarcoplasmolysis and necrosis fibers dramatically decreased. Histomorphometric evaluation results of the nerve in its various parts and immunohistochemistry results also showed improve nerve conduction in all groups, especially the MC + MSC group compared to the Tr group. All results were time dependent and in most cases at 8th week were better the other times. Overall,
the results of this study showed that the simultaneous use of MCs and MSCs, especially in the eighth week, accelerated the healing of the sciatic nerve and TCM following reinnervation.
Turkish version of the new instrument for Orthorexia Nervosa -Test of Orthorexia Nervosa (TON-17): a validity and reliability study
Authors: Yassibas Emine , Ayyıldız Feride 
Published: December 2022

AbstractBackground There are several scales to evaluate orthorexia nervosa (ON), a pathological obsession, fixation or preoccupation with healthy foods. However, studies report that some of these scales have poor internal consistency and some do not have test-retest reliability, therefore new scales are needed to evaluate ON correctly. This study aims to adapt the Test of Orthorexia Nervosa-17 (TON-17) into Turkish and verify its validity and reliability. Methods The study included a total of 539 adults, 131 men (24.3%) and 408 women (75.7%), with a mean age of 30.2 ± 12.26 years. A reliability analysis was performed and a confirmatory factor analysis (CFA) to test its construct validity. Time invariance of the scale was examined by test-retest analysis, and its convergent validity was evaluated by a correlation analysis conducted to test relationships between the scale and other theoretically relevant instruments (EAT-26 and OBQ-9). Analyses were conducted using SPSS Version 23 and the AMOS program. Results The Cronbach's α internal consistency coefficient of the total scale was found to be 0.820, suggesting a strong internal consistency. The Cronbach's α values of its factors were 0.681 for the Factor 1, 0.643 for the Factor 2, and 0.726 for the Factor 3. In addition, the test-retest reliability was found as 0.868 for the total scale, suggesting an excellent reliability. The most of fit indices (CMIN/df, RMSEA, AGFI, NFI and TLI) of the scale were acceptable, and the GFI indicated a good model fit. Conclusion This study has shown that the Turkish version of TON-17, which is a new tool with three-factor structure to evaluate both healthy and unhealthy orthorexia, is valid and reliable scale. Studies of TON-17 on diverse cultures will contribute to the literature. Therefore, examining the validity and reliability of TON-17 in diverse cultures and populations may contribute to developing the gold standard scale for evaluating ON in future studies.
Universal properties of non-Hermitian viscoelastic channel flows
Authors: Li Yuke , Steinberg Victor 
Published: December 2022

Abstract
An addition of long-chain, flexible polymers strongly affects laminar and turbulent Newtonian flows. In the laminar inertia-less viscoelastic channel flow, the supercritical elastic non-normal mode instability at finite-size perturbations leads directly to chaotic flow. Then three chaotic flow regimes: transition, elastic turbulence (ET), and drag reduction (DR), accompanied by elastic waves, are observed and characterized. Here we show that independently of external perturbation strength and structure, chaotic flows above the instability onset in transition, ET, and DR flow regimes reveal similar scaling of flow properties with Wi, defined the degree of polymer stretching, stream-wise streaks self-organized into cycling self-sustained process, synchronized by elastic waves, and universal scaling of elastic wave speed with Wi. Moreover, these properties persist over the entire channel length above the instability threshold. It means that only an absolute instability exists in inertia-less viscoelastic channel flows, whereas a convective instability is absent. This unexpected discovery is in a sharp contrast with Newtonian flows, where both convective and absolute instabilities are always present in open flows. It probably transpires due to differences in nonlinear terms in an elastic stress equation, where except an advective term, two key terms describing polymer stretching along the channel length exist.
Food profiling using innovative voltammetric metallic-glassy carbon electrodes evaluated by clustering metrics
Authors: WÓJCIK Szymon , MIRCESKI Valentin , BAŚ Bogusław , JAKUBOWSKA Małgorzata 
Published: December 2022

Abstract
This work proved that the quadruple-disk electrodes - iridium-platinum, platinum-glassy carbon, and iridium-glassy carbon can successfully work as a single sensor and act as voltammetric electronic tongue in food profiling. Current samples obtained with square-wave voltammetry (SWV) were additionally interpreted by a novel technique termed double-sampled differential square-wave voltammetry (DSSWV), which allowed for increasing the resolution and extracting the full, hidden information available in the signals. Four clustering validity indices: Calinski – Harabasz index, Davies – Bouldin index, Silhouette index and gap statistics were applied to select the optimal sensor and the current samples interpretation strategy. These four coefficients indicated the best iridium-platinum electrode combined with overall cathodic potential modulation using the technique of DSSWV. Correct clustering of objects, i.e., samples of five different isotonic beverages from one producer, was confirmed using principal component analysis and polar dendrogram. At the same time, it has been shown that in some variants of measurements and signal interpretation, it is not possible to correctly group the samples.
3D shape reconstruction of the femur from planar X-ray images using statistical shape and appearance models
Authors: Nolte Daniel , Xie Shuqiao , Bull Anthony M. J. 
Published: December 2022

Abstract
Major trauma is a condition that can result in severe bone damage. Customised orthopaedic reconstruction allows for limb salvage surgery and helps to restore joint alignment. For the best possible outcome three dimensional (3D) medical imaging is necessary, but its availability and access, especially in developing countries, can be challenging. In this study, 3D bone shapes of the femur reconstructed from planar radiographs representing bone defects were evaluated for use in orthopaedic surgery. Statistical shape and appearance models generated from 40 cadaveric X-ray computed tomography (CT) images were used to reconstruct 3D bone shapes from digital reconstructed radiographs simulating bone defects between 0% and 50% in anterior posterior (AP) and anterior posterior/medial lateral (AP/ML) directions by comparing the images to projections of the shape model instance. As error metrics for the comparison, measures evaluating the distance between contour lines of the projections as well as a measure comparing similarities in image intensities were used. The results were evaluated using the root mean squared distance for surface error as well as differences in commonly used anatomical measures, including bow, femoral neck, diaphyseal-condylar and version angles between reconstructed surfaces from the shape model and the intact shape reconstructed from the CT image. The reconstructions had average surface errors between 1.59 mm and 3.59 mm with reconstructions using the contour error metric from the AP/ML directions being most accurate. Predictions of bow and femoral neck angles were well below the clinical threshold accuracy of 3°, diaphyseal-condylar angles were around the threshold of 3° and only version angle predictions of between 5.3° and 9.3° were above the clinical threshold, but within the range of accuracies obtained using computer navigation. This study shows that the accuracy of reconstructions combining the use of planar radiographs and statistical shape and appearance models is sufficient for use in orthopaedic reconstruction surgeries.
Boundedness of the Cesàro operator in Dunkl Hardy space * †
Authors: Hu zhuoran 
Published: December 2022

Abstract
Note: Please see pdf for full abstract with equations.
The Hardy space $H_{\lambda}^{p}(\RR^{2}_+)$ associated with the Dunkl transform $\SF_{\lambda}$ and the Dunkl operator $D_x$\,(\,where$D_xf(x)=f'(x)+\frac{\lambda}{x}[f(x)-f(-x)]$\,) is the set of functions $F(x, y)=u(x, y)+iv(x, y)$ on the upper half plane $\RR_+^2=\{(x, y): x\in\RR, y>0\}$ satisfying the $\lambda$-Cauchy-Riemann equations: $D_xu-\partial_y v=0, \partial_y u +D_xv=0$ and $\sup_{y>0}\int_{\RR}|F(x, y)||x|^{2\lambda}dx<0$. In this paper, we will prove that the Ces\`{a}ro operator is bounded in the Dunkl Hardy space $H_{\lambda}^{p}(\RR^{2}_+)$ for every $p\geq\frac{2\lambda}{2\lambda+1},\,\lambda>0$:
where $C$ is a constant depending on $\alpha$, $p$, and $\lambda$. The average function for the Ces\`{a}ro operator $C_{\alpha}$ is $\phi_{\alpha}(t)=\alpha(1-t)^{\alpha-1}$ with $\alpha>0$.
2000 MS Classification:
Prognosis value and positive association of Rab1A/IL4Rα aberrant expression in gastric cancer
Authors: Li Haoran , Cheng Zhengwu , Jiang Bin , Shao Xinyu , Xu Menglin 
Published: December 2022

Abstract
Gastric cancer (GC) is the most common gastrointestinal cancer with the leading causes of cancer-related death worldwide. Many GC patients are diagnosed at the advanced stage, the five-year survival rate is unsatisfactory. Rab1A expression was significantly correlated with IL4Rα expression in non-small cell lung cancer. However, the potential correlation of Rab1A and IL4Rα in both expression and prognosis remain largely unknown in gastric cancer. In this study, Rab1A/IL-4Rα was obviously elevated in GC tissues compared with the para-cancerous tissues and Rab1A/IL-4Rα overexpression led to poor prognosis in GC patients. Rab1A expression was remarkably associated with the expression of IL-4Rα in GC tissues by IHC analysis. In addition, the mRNA expression of Rab1A was closely related with the IL-4Rα mRNA expression by qPCR in GC tissue. Furthermore, the Kaplan-Meier analysis indicated that the group with both negative of Rab1A and IL-4Rα expression had longer five-year survival rates compared with the other group. Besides, the group with both positive of Rab1A and IL-4Rα expression had a worse prognosis compared with the other group. Finally, the nomograms predicting 3 and 5-year overall survival revealed that Rab1A/IL-4Rα expression played crucial roles in predicting the prognosis of GC patients. Therefore, Rab1A/IL-4Rα may played a vital role in GC, which may provide a new visual field on the targeted therapy of GC.
A novel score to estimate thrombus burden and predict intracranial hypertension in cerebral venous sinus thrombosis
Authors: Wang Zhongao , Dandu Chaitu , Guo Yibing , Gao Meini , Lan Duo , Pan Liqun , Zhou Da , Ding Yuchuan , Ji Xunming , Meng Ran 
Published: December 2022

Abstract
Background: The current methods to evaluate the severity of cerebral venous sinus thrombosis (CVST) lack patient-specific indexes. Herein, a novel scoring method was investigated to estimate the thrombus burden and the intracranial pressure (ICP) of CVST.
Methods: We consecutively included eligible patients, with a first-time diagnosis of CVST by contrast-enhanced magnetic resonance venography (CE-MRV) or computed tomography venography (CTV), in this retrospective study from January 2019 through December 2021. A comprehensive CVST-Score was established according to magnetic resonance black blood thrombus imaging (MRBTI) to estimate the thrombus burden semi-quantitatively. The relationship between CVST-Score and ICP was explored to assess its potential to monitor ICP noninvasively.
Results: A total of 87 patients were included into the final analysis. The CVST-Scores in different ICP subgroups were as follows: 4.29±2.87 in ICP＜250mmH2O subgroup, 11.36±3.86 in ICP =250-330mmH2O subgroup and 14.99±3.15 in ICP＞330mmH2O subgroup, respectively (p<0.001). For patients with ICP ≤330mmH2O, CVST-Scores were linearly and positively correlated with ICP (R2=0.53). The receiver operating characteristic (ROC) curves showed the optimal CVST-Score cut-off values to predict ICP ≥250mmH2O and ＞330mmH2O were 7.15 and 11.62, respectively (P<0.001). Multivariate analysis indicated CVST-Score as an independent predictor of ICP ≥250mmH2O (odds ratio, 2.15; 95% confidence interval, 1.49-3.10; p<0.001).
Conclusions: A simple and noninvasive CVST-Score could be employed to rapidly estimate the thrombus burden and predict the severity of intracranial hypertension in patients with CVST. It can be used to evaluate therapeutic responses and avoid unnecessary invasive procedures at long-term follow-up.
Fractional CO2 laser in the treatment of nail psoriasis, how can it help?
Authors: Afify Ahmed Abdelfattah , Shaheen Maha Adel , El-Banna Mahmoud Gamal 
Published: December 2022

Abstract
Background: Treating nail psoriasis is often a time-consuming challenge with an unsecure outcome. Response to the treatment is variable and relapses are common. Systemic treatments have multiple systemic side effects and lack of the patient compliance makes intra-lesional therapies not the best choice for treatment of nail psoriasis. We aimed to evaluate and compare the efficacy and side effects of methotrexate versus calcipotriol plus betamethasone two compound formula when applied topically to psoriatic nails after fractional CO2 laser.
Methods: This comparative pilot study included 20 patients with nail psoriasis. One side was treated with fractional CO2 laser followed by the application of topical methotrexate (Group A) and the other side with fractional CO2 laser followed by topical (Calcipotriol 0.05 mg/gm + Betamethasone 0.5 mg/gm) (Group B). 4 sessions were done, once every 2 weeks. Results: There was a high statistical significant decrease in total NAPSI score in group A at 1(P = 0.000) and 2 months (P = 0.000). There was a high statistical significant decrease in total NAPSI score in group B at 1(P = 0.001) and 2 months (P = 0.001). There was no statistical significant difference regarding total NAPSI score between both group A and B at 0 (P = 0.271), 1(P = 0.513) and 2 months (P = 0.647).
Conclusion: Combined fractional CO2 laser with either topical MTX or topical betamethasone plus calcipotriol two compound formula is effective treatment for nail psoriasis.
To compare the efficacy and safety of radiotherapy before and after anti-CD19-CAR T-cell therapy in patients withrelapsed/refractory DLBCL
Authors: Li Jingyi , Mu Juan , Li Xin , Li Qing , Jiang Yili , Wang Jia , Mou Nan , Deng Qi 
Published: December 2022

Abstract
Background: What is the difference in efficacy and side effects of radiotherapy bridging CAR-T therapy versus CAR-T therapy followed by radiotherapy?
Patients and methods: Fourteen R/R DLBCL patients received radiotherapy before CAR-T therapy (R-C group). R-C group was divided into: 1-3 months radiotherapy before CAR-T therapy (1-3 mons) group and more than 3 months before CAR-T therapy (more than 3 mons) group. Seventeen patients received radiotherapy 2-3 months after CAR-T therapy (C-R) group.
Results: In R-C group, ORR was 81.82% and CR was 54.55%. In C-R group, ORR was 64.71% and CR was only 35.29% after CAR-T therapy, but CR became 64.71% after the following radiotherapy. CAR-T cell peaks were higher in R-C group than in C-R group, and higher in R-C (1-3 mons) group than that in R-C (more than 3 mons) group. Three patients in R-C group died of CRS, no patient in C-R group died of CRS. There was no difference in CRS and ICANS in R-C and C-R group. CRS and ICANS grades were higher in R-C (1-3 mons) group than that in R-C (more than 3 mons) group.
Conclusions: Radiotherapy bridging CAR-T therapy had higher ORR. While, CAR-T therapy followed by radiotherapy might improve CR without higher CRS and ICANS.
Trial registration number ChiCTR1800019622.