bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Brief Review of Radioactive Materials for Therapeutic and Diagnostic Purposes
Authors: Alam Md. Aftab , Bharti Manisha , Rao Gudhanti Siva Nago Koteswara , Sharma Pramod Kumar 
Published: October 2022

Abstract:Radiation treatment has been advancing ever since the discovery of X-rays in 1895.The goal of radiotherapy is to shape the best isodose on the tumor volume while preserving normal tissues. There are three advantages: patient cure, organ preservation, and cost-effectiveness. Randomized trials in many various forms of cancer (including breast, prostate, and rectum) with a high degree of scientific proof confirmed radiotherapy's effectiveness and tolerance. Such accomplishments, which are critical to patients' quality of life, have been supported in the past. Radiopharmaceuticals were developed for the diagnosis and therapy of a variety of disorders, hyperthyroidism, bone discomfort, cancer of the thyroid gland, and other conditions like metastases, renal failure, and myocardial infarction and cerebral perfusion. It is also possible to sterilize thermo-labile materials with the radioactive substance. This includes surgical dressings and a wide range of other medical supplies. Nuclear medicine provides various advantages, including tumor localization, safe diagnosis, no radiation buildup, and excellent treatment effectiveness. Nowadays, the field of nuclear pharmacy is focused on developing novel radioactive pharmaceutical substances that will be useful.
Solid Lipid Nanoparticles (SLNs): Advancements in Modification
Strategies Toward Drug Delivery Vehicle
Authors: Al-Sayadi Galal Mohsen Hussein , Verma Abhishek , Choudhary Yash , Sandal Pallavi , Patel Preeti , Singh Dilpreet , Gupta Ghanshyam Das , Kurmi Balak Das 
Published: October 2022

Abstract:
Solid lipid nanoparticles are at the cornerstone of the swiftly growing area of medical
nanotechnology, having several potential functions in drug delivery, research, clinical care, and a
variety of other fields. They provide the opportunity of developing novel therapies due to their
unique properties, such as small particle size and being prepared from physiological biodegradable
lipids. The loading of bioactive molecules into nanocarriers is a novel drug delivery prototype
employed for various drug targeting levels. Hence, SLNs hold a great promise for achieving the
aim of targeted and controlled drug delivery. For this reason, they have attracted the extensive
attention of scientists and researchers. This review is based on recent studies and research, and
here we present advantages, disadvantages, and preparation methods, several advanced
modifications, targeting strategies, and recent applications of solid lipid nanocarriers in drug
delivery systems.
Patient Monitoring System using Blockchain and IoT Technology
Authors: Shukla Meenu , Sethi Deepak , Bindal Loveneesh , Mani Kushal , Upadhyay Kunal , Sharma Mitul 
Published: October 2022

Background:Recently, the construction of a smart city has accelerated due to developing technologies such as 5G and the Internet of things (IoT). The IoT is gaining access day by day in the area of the remote monitoring system. Along with smart city concepts, intelligent patient monitoring systems and intelligent health are being developed. Combining the two, here, patients have a nurse navigation system and a doctor emergency call system. IoT improves the effectiveness of medical equipment by providing real-time monitoring of patient health, in which sensors collect data from patients with less human errors. In IoT, the patient's parameters get transmitted through medical devices via a gateway to the centralized system, where it is stored and analyzed.Objective:In this paper, we have proposed an intelligent patient monitoring system for monitoring the patients' health condition automatically through sensors-based connected links. The system is more intelligent that it can be able to detect the critical condition of a patient by processing sensor data and instantly provides a notification to doctors/nurses as well as hospital in-charge personnel. The doctors and nurses get benefited from this system by observing their corresponding patients remotely without visiting to the particular seat of the patient.Methods:An idea has been proposed to use the centralized processing of IoT devices along with the rigid security and privacy of the classical blockchain to overcome the computation expense challenge with blockchain and the security and privacy threat of the IoT systems. We are developing a system in the field of medical care to enhance the functioning of Medicare systems and provide patients with more ease and hassle-free procedures of the Medicare system, i.e., hospitals, laboratories, dispensaries, chemists, druggists, etc.Results:This model helps in getting rid of this issue faced by all of us. There is a separate blockchain of different verified medical stores linked within the networks, which will be managed by the central hub based on their ratings, reviews, and stock availability.Conclusion:The exponential expansion of blockchain technology in healthcare is also astonishing and has a tremendous impact on the industry. By assessing prior activities, the idea is proposed to use a centralized database system with more privacy and security to gap between the healthcare industry and blockchain technologies has been addressed in this paper.
Energy Treasure Hunts
Authors:   Barry Consulting Services LLC, Barry John 
Published: October 2022

This discussion will highlight the steps necessary to find energy savings opportunities within any type of processing facility. An Energy Treasure Hunt or €œKaisen€ is a three day, plant-wide activity (but can take up to 5 days for large facilities) that focuses on:< ![if !supportLists] >1 < ![endif] >Low cost and no cost actions to reduce energy consumption< ![if !supportLists] >2 < ![endif] >Learning ways to continuously improve and reduce energy consumption< ![if !supportLists] >3 < ![endif] >Brainstorming ways to reduce energy use throughout the facility 4 < ![endif] >Identifying, analyzing and evaluating energy savings opportunities by observing daily operations 5 < Quantifying those opportunities for energy reduction using a standard methodology and calculationFacility employees implement the Energy Treasure Hunt process with the aid of outside energy experts.The purpose of an Energy Treasure Hunt is to:< ![if !supportLists] >1 < ![endif] >Combine knowledge from other plants, suppliers, consultants< ![if !supportLists] >2 < ![endif] >Go and see, listen and smell< ![if !supportLists] >3 < ![endif] >Identify energy use in the facility< ![if !supportLists] >4 < ![endif] >Conceive new ideas and share exiting ones< ![if !supportLists] >5 < ![endif] >Find new ways to save< ![if !supportLists] >6 < Increase energy awarenessOnce the Energy Treasure Hunt has been completed, the facility is responsible to implement the projects that meet the necessary return on investment.
Maintaining Compliance with Combustible Dust Regulations
Authors:   ADF Engineering, Williamson Matthew 
Published: October 2022

Since the deadline for completion of Dust Hazard Analyses has passed per NFPA 652, implementation of the identified dust hazard controls must be completed and the DHA program must be maintained. Some dust hazard mitigation requirements may be challenging or too costly to implement, especially in truck loadout bays and banks of concrete silos, where common dust protection equipment may not be sufficient to mitigate the hazards. How can concrete silos with common walls and feed systems be effectively isolated? How can large dust clouds generated while loading meal into trucks be sufficiently suppressed? What happens if you do not have a Dust Hazard Analysis in place and how do you maintain it once you do? What further changes are coming to the combustible dust standards? This presentation will address effective dust control, aspiration best practices, and risk mitigation strategies, as well as DHA compliance strategies and future direction for the standards.
PENGARUH BUKU CERITA BERGAMBAR TERHADAP KEMAMPUAN MEMBACA PEMAHAMAN DAN HASIL BELAJAR SISWA
Authors: Suprapto Hidayah Mulyaningsih 
Published: October 2022

Penelitian ini bertujuan untuk mengetahui: (1) pengaruh penggunaan media buku cerita bergambar terhadap kemampuan membaca pemahaman siswa kelas IV sekolah dasar, (2) pengaruh penggunaan media buku cerita bergambar terhadap hasil belajar siswa kelas IV sekolah dasar, dan (3) pengaruh penggunaan media buku cerita bergambar terhadap kemampuan membaca pemahaman dan hasil belajar siswa kelas IV.Penelitian ini merupakan penelitian kuasi eksperimen dengan desain Pretest-Posttest Non-Equivalent Control Group Design. Populasi dalam penelitian ini adalah siswa kelas IV SD N se-Kecamatan Prambanan Sleman, Yogyakarta yang telah menerapkan Kurikulum 2013. Sampel penelitian adalah 84 siswa SD Negeri Delegan 2, SD Negeri Delegan 3, dan SD Negeri Dadapsari. Sampel penelitian dibagi menjadi kelas eksperimen dan kelas kontrol dengan teknik cluster random sampling. Kelas eksperimen menggunakan buku cerita bergambar dan kelas kontrol menggunakan buku kurikulum 2013. Kelas eksperimen berjumlah 56 siswa dan kelas kontrol berjumlah 28 siswa. Instrumen yang digunakan untuk mengukur kemampuan membaca pemahaman dan hasil belajar siswa adalah lembar kuisoner tes tertulis. Teknik analisis menggunakan uji Paired Sample t-Test dengan taraf signifikansi 0,05Hasil penelitian menunjukkan bahwa: (1) buku cerita bergambar berpengaruh terhadap kemampuan membaca pemahaman siswa dengan hasil nilai Sig (2-tailed) pada kelas eksperimen diperoleh nilai t hitung (9,346) t tabel (2,05) dan, (2) buku cerita bergmbar berpengaruh terhadap hasil belajar, dengan uji t menunjukkan nilai t hitung (13,914) t tabel (2,05). Simpulan yang dihasilkan adalah bahwa buku cerita bergambar berpengaruh terhadap kemampuan membaca pemahaman dan hasil belajar siswa kelas IV sekolah dasar. Hasil uji efektifitas diketahui persentase peningkatan pada kelas eksperimen mempunyai peningkatkan lebih baik dibandingkan kelas kontrol. Kata Kunci : buku cerita bergambar, kemampuan membaca pemahaman, hasil belajar
Utility of the Comprehensive Health and Stringency Indexes in Evaluating Government Responses for Containing the Spread of COVID-19 in India: Ecological Time-Series Study
Authors: Kishore Kamal , Jaswal Vidushi , Pandey Anuj Kumar , Verma Madhur , Koushal Vipin 
Published: October 2022

Background
Many nations swiftly designed and executed government policies to contain the rapid rise in COVID-19 cases. Government actions can be broadly segmented as movement and mass gathering restrictions (such as travel restrictions and lockdown), public awareness (such as face covering and hand washing), emergency health care investment, and social welfare provisions (such as poor welfare schemes to distribute food and shelter). The Blavatnik School of Government, University of Oxford, tracked various policy initiatives by governments across the globe and released them as composite indices. We assessed the overall government response using the Oxford Comprehensive Health Index (CHI) and Stringency Index (SI) to combat the COVID-19 pandemic.

Objective
This study aims to demonstrate the utility of CHI and SI to gauge and evaluate the government responses for containing the spread of COVID-19. We expect a significant inverse relationship between policy indices (CHI and SI) and COVID-19 severity indices (morbidity and mortality).

Methods
In this ecological study, we analyzed data from 2 publicly available data sources released between March 2020 and October 2021: the Oxford Covid-19 Government Response Tracker and the World Health Organization. We used autoregressive integrated moving average (ARIMA) and seasonal ARIMA to model the data. The performance of different models was assessed using a combination of evaluation criteria: adjusted R2, root mean square error, and Bayesian information criteria.

Results
implementation of policies by the government to contain the COVID-19 crises resulted in higher CHI and SI in the beginning. Although the value of CHI and SI gradually fell, they were consistently higher at values of >80% points. During the initial investigation, we found that cases per million (CPM) and deaths per million (DPM) followed the same trend. However, the final CPM and DPM models were seasonal ARIMA (3,2,1)(1,0,1) and ARIMA (1,1,1), respectively. This study does not support the hypothesis that COVID-19 severity (CPM and DPM) is associated with stringent policy measures (CHI and SI).

Conclusions
Our study concludes that the policy measures (CHI and SI) do not explain the change in epidemiological indicators (CPM and DPM). The study reiterates our understanding that strict policies do not necessarily lead to better compliance but may overwhelm the overstretched physical health systems. Twenty-first–century problems thus demand 21st-century solutions. The digital ecosystem was instrumental in the timely collection, curation, cloud storage, and data communication. Thus, digital epidemiology can and should be successfully integrated into existing surveillance systems for better disease monitoring, management, and evaluation.
Leveraging Cost Accounting to Manage Earnings: Evidence from Toshiba’s Semiconductor Business
Authors: Ramasubramanian Hari , Gujarathi Mahendra R. , Feldmann Dorothy 
Published: October 2022

ABSTRACT
This case pertains to the interplay of cost accounting, performance measurement, and financial reporting issues in Toshiba’s semiconductor business. It addresses how Toshiba manipulated its reported profits by inappropriately allocating its budgeted fixed overheads and not recognizing inventory losses in a timely manner in the financial statements. These manipulations overstated profits of the semiconductor business by ¥36.0 billion, almost a quarter of the total of Toshiba Corporation’s ¥151.8 billion profit overstatement. The investigation report indicated that the profit manipulations were a likely outcome of top management’s unrealistic expectations. For the semiconductor business of Toshiba, the timely recognition of inventory losses would have offset the profit misstatements resulting from the inappropriate allocation of budgeted fixed overheads. Alternatively, proper allocation of budgeted fixed overheads would have reduced or even avoided the need to recognize inventory losses. The case provides an integrative view of cost and financial accounting.
Trancendental Values In Pancasila As The Personality Of The Indonesian Nation (Perspective From A Muslim)
Authors: Basri Basri , Kurniaty Yulia , Krisnan Johny 
Published: October 2022

It turns out that when studied more deeply there is a match between the teachings of Islam and the values of Pancasila. On this basis, the researcher expresses the opinion that there is no reason to contradict the teachings of Islam and Pancasila. In fact, according to the researcher, the values of Pancasila are complemented by Islamic teachings and it is possible that the values of Pancasila come from Islamic teachings. Therefore, there is no need for Muslims to question Pancasila as the basic philosophy of the Indonesian nation and state. For others, when there is a reaction from Muslims, for example there is an issue to replace Pancasila with another ideology, there is no need to react excessively, because it cannot happen and be conducted by Muslims. Such an attitude is just a reaction to what happened, in which some Muslims are seen as contradicting the values of Pancasila as the personality of the Indonesian nation. This is the real problem that needs to be found at the root of the problem. Keywords: Pancasila-Personality-Nation-Indonesia
Takotsubo Syndrome and Its Genetic Relationship: Case Report and Narrative Literature Review
Authors: Ferrari Natalia , Santos Mariana Gomes de Oliveira , Alvarenga Marcela Rodrigues da Cunha , Moraes Leticia Peres , Miguel Dafane Lima , Moser Melchior , Quessada Flavio 
Published: October 2022

Introduction: Takotsubo Syndrome (TTS) is presented as a temporary loss of systolic function, it is usually associated with emotional or physical stress. However, its pathophysiology is not well defined. Thus, this article seeks the relationship between the genetic factor and the development of Takotsubo Syndrome.

Methodology: The study is about a narrative review and two case reports on TTS.

Results: TTS is related to the excess of catecholamines, and its genetic linkage is strongly considered due to recent studies where occasionally it has been noticed its hereditary connections, such as: increased cardiac sensitivity to catecholamines and cardiac vulnerability to adrenergic stressors, impaired regulation of norepinephrine release, syndrome fragile X, and CD36 deficiency.

Discussion: There is still no conclusion of the leading factors to TTS. However, being female, being in the postmenopausal period, and exposed to stressful conditions are some of the risk factors that can develop the disease, and which are better accepted by the scientific community.

Conclusions: Although TTS is a disease of low prevalence, it is increasingly present in the routine of the cardiologist. The great difficulty lies in its diagnosis as it does not present a pathognomonic symptom and it is similar to other diseases, such as ACS. This causes it to pass absent-mindedly during the emergency primary investigation. Thus, there is a need to expand studies related to this disease and to investigate its genetic association.
Utilizing Point of Care Ultrasound to Evaluate for Small Bowel Obstruction in Emergency Department Patients
Authors: Biggs Danielle , Kolster Laura , Patwa Amy , Graziano Andrew , Pandey Devansh , Heiney Joe , Walsh Brian 
Published: October 2022

Small bowel obstruction (SBO) is a common diagnosis made in the Emergency Department (ED) representing about 15% of hospital admissions for acute abdominal complaints. We sought to investigate if bedside ultrasound as performed by ED physicians is a reliable test to diagnose and rule out SBO. This was a prospective cohort study of nonconsecutive patients who presented to an academic, suburban ED with a census of approximately 100,000 patients per year between November 2018 and May 2019. Patients with a history of prior abdominal surgeries who presented to the ED with nausea and/or vomiting and had a CT Abdomen and Pelvis with PO contrast ordered by their provider were consented for a bedside ultrasound. Interpretation was performed by the physician performing the study at bedside. The physician performing the study identified the largest loops of bowel in each of the four quadrants and measured the identified loops from bowel wall to bowel wall. A diameter of greater than 2.5 cm was considered positive for dilated bowel and probable obstruction. At the completion of the study the physician entered their interpretation of the result which was later reviewed by an ultrasound fellowship-trained physician. There were 101 patients included in the study. Study personnel were accurate in 92% of cases. Overall the sensitivity of point of care ultrasound (POCUS) for SBO was 90% (72.7 to 97.8) and specificity was 92% (82.7 to 96.9). The positive and negative likelihood ratios were 10.76 (4.95 to 23.38) and 0.11 (0.04 to 0.33). Given that our study demonstrated a low negative likelihood ratio, those with low probability of an SBO on history could have an ultrasound examination performed at the bedside which could be sufficient to rule out this disease without requiring patients to undergo further imaging.
Class III malocclusion with traumatic unilateral maxillary central incisor loss treated using orthodontic miniscrews: a case report
Authors: Yoshida Michiko , Seiryu Masahiro , Mayama Atsushi , Takano-Yamamoto Teruko , Mizoguchi Itaru 
Published: October 2022

Abstract
The present article reports the successful non-extraction orthodontic treatment using miniscrew anchorage in a patient who presented with maxillary left central incisor loss and unstable jaw movements. The chief complaints of the 23-year-old female patient were her protruding teeth and crowding of the mandibular anterior segment. The patient lost her maxillary left central incisor as a result of a traumatic injury during childhood. However, the crown was saved and attached to the adjacent teeth. The patient was diagnosed with a skeletal Class III and Angle Class III dental malocclusion. The jaw movements determined by a 6 degrees of freedom jaw movement recording system were unstable and irregular. Miniscrew anchorage was applied for distalisation of the maxillary right dentition and the mandibular dentition during non-extraction treatment. The maxillary left dentition was mesialised using miniscrew anchorage to close the space as a result of the lost maxillary left central incisor. After an active treatment duration of 36 months, the patient achieved a Class II molar relationship on the left side, a Class I on the right side, an optimal overjet and overbite, and a pleasing facial profile. Despite the asymmetric molar relationships, functionally stable and smooth jaw movements were established. The skeletal, occlusal and functional stability remained satisfactory after a 2-year retention period. In conclusion, miniscrew anchorage was valuable in supporting asymmetric tooth movement during non-extraction appliance treatment in a patient who presented with traumatic unilateral tooth loss.
Comparison of tree-based methods used in survival data
Authors: Yabaci Aysegul , Sigirli Deniz 
Published: October 2022

Abstract
Survival trees and forests are popular non-parametric alternatives to parametric and semi-parametric survival models. Conditional inference trees (Ctree) form a non-parametric class of regression trees embedding tree-structured regression models into a well-defined theory of conditional inference procedures. The Ctree is applicable in a varietyof regression-related issues, involving nominal, ordinal, numeric, censored, as well as multivariate response variables and arbitrary measurement scales of covariates. Conditional inference forests (Cforest) consitute a survival forest method which combines a large number of Ctrees. The Cforest provides a unified and flexible framework for ensemble learning in the presence of censoring. The random survival forests (RSF) methodology extends the random forests method enabling the approximation of rich classes of functions while maintaining generalisation errors low. In the present study, the Ctree, Cforest and RSF methods are discussed in detail and the performances of the survival forest methods, namely the Cforest and RSF have been compared with a simulation study. The results of the simulation demonstrate that the RSF method with a log-rank score distinction criteria outperforms the Cforest and the RSF with log-rank distinction criteria.
Estimating the population mean using a complex sampling design dependent on an auxiliary variable
Authors: Chaudhuri Arijit , Samaddar Sonakhya 
Published: October 2022

Abstract
In surveying finite populations, the simplest strategy to estimate a population total without bias is to employ Simple Random Sampling (SRS) with replacement (SRSWR) and the expansion estimator based on it. Anything other than that including SRS Without Replacement (SRSWOR) and usage of the expansion estimator is a complex strategy. We examine here (1) if from a complex sample at hand a gain in efficiency may be unbiasedly estimated comparing the “rival population total-estimators” for the competing strategies and (2) how suitable model-expected variances of rival estimators compete in magnitude as examined numerically through simulations.