bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reversing Multidrug‐Resistant Escherichia coli by Compromising Its BAM Biogenesis and Enzymatic Catalysis through Microwave Hyperthermia Therapy
Authors: Mao Congyang , Jin Wanyu , Xiang Yiming , Zhu Yizhou , Wu Jun , Liu Xiangmei , Wu Shuilin , Zheng Yufeng , Cheung Kenneth M.C. , Yeung Kelvin Wai Kwok 
Published: April 2022

AbstractMultidrug‐resistant (MDR) bacteria are emerging and disseminating rapidly, undoubtedly posing an urgent threat to global public health. One particular concern is that MDR Gram‐negative bacteria are immunized to available antibiotics owing to a series of biogenetic effects, including the β‐barrel assembly machine (BAM complex) in the outer membrane, MDR efflux pumps, and enzymatic degradation/modification, which are known to induce antibiotic resistance (AbR). Here, this work identifies that the AbR mechanisms of MDR Escherichia coli become compromised and sensitive again to conventional antibiotics, when the temperature of infected tissues is elevated to ≈50 °C in situ. This thought is realized by the microwave‐driven poly(lactic‐co‐glycolic acid) microparticles that may effectively convert electromagnetic radiation to thermal energy. The microwave hyperthermia (MWH) therapy not only interrupts the essential surface‐exposed BamA protein of the BAM complex, but also enhances the permeability of the outer membrane and inhibits the action of MDR efflux pumps. MWH also impairs the hydrogen bond interaction between the catalytic residues of bacterial enzymes and functional groups of antibiotic molecules. Lastly, this work demonstrates these combined inhibitors can revitalize the bactericidal effects of conventional antibiotics in MDR Escherichia coli‐associated deep tissue infections.
Boosting H2 Production from a BiVO4 Photoelectrochemical Biomass Fuel Cell by the Construction of a Bridge for Charge and Energy Transfer
Authors: Wang Zhaoqi , Guo Yuhao , Liu Mu , Liu Xiaolei , Zhang Haipeng , Jiang Weiyi , Wang Peng , Zheng Zhaoke , Liu Yuanyuan , Cheng Hefeng , Dai Ying , Wang Zeyan , Huang Baibiao 
Published: April 2022

AbstractUtilizing a photoelectrochemical (PEC) fuel cell to replace difficult water oxidation with facile oxidation of organic wastes is regarded as an effective method to improve the H2 production efficiency. However, in most reported PEC fuel cells, their PEC activities are still low and the energy in organic fuels cannot be effectively utilized. Here, a unique BiVO4 PEC fuel cell is successfully developed by utilizing the low‐cost biomass, tartaric acid, as an organic fuel. Thanks to the strong complexation between BiVO4 and tartaric acid, a bridge for the charge and energy transfer is successfully constructed, which not only improves the photoelectric conversion efficiency of BiVO4, but also effectively converts the chemical energy of biomass into H2. Remarkably, under AM1.5G illumination, the optimal nanoporous BiVO4 photoanode exhibits a high current density of 13.54 mA cm−2 at 1.23 V vs reversible hydrogen electrode (RHE) for H2 production, which is higher than that of previously reported PEC water splitting systems or PEC fuel cell systems. This work opens a new path for solving the low PEC H2 production efficiency and provides a new idea for improving the performances and energy conversion efficiency in traditional PEC fuel cells.
Lithography‐Free Fabrication of Periodic Metal Network for Ultra‐Sensitive Transparent and Unidirectional Strain Sensor in Health‐Monitoring Applications
Authors: Mondal Indrajit , Kulkarni Giridhar U. 
Published: April 2022

AbstractTools with the ability of continuous health monitoring have received immense interest in biomedical engineering and the internet of things (IoT). Ultra‐sensitive wearable strain sensors are such tools having the potential to bring cost‐effectiveness in the therapeutic field. The present work describes the development of a transparent strain sensor comprising parallel Au micro‐wires semi‐embedded in polydimethylsiloxane (PDMS). A lithography‐free technique is employed for the cost‐effective fabrication, where a parallel‐crack network, formed by the gravity‐flow of a crackle precursor on an inclined silicon substrate, serves as a stencil for the parallel micro‐wire formations. The ultimate device is realized by transferring the wires into the PDMS substrate. The sensor with ≈85% transmittance shows a resistance change of ≈370% for an applied strain of 2%. The mechanism relies on the formation of nano‐break junctions in the micro‐wires due to applied strain leading to discontinuation in the electron percolation. The unidirectional sensor having such ultra‐high sensitivity and cyclic stability is exploited for the detection of resonance and dissonance oscillations of a coupled cantilever. Besides, the sensor is utilized for speech recognition, gesture detection and radial augmentation index calculation from the blood‐pulse pattern, supporting its feasibility as a potential tool in robotics and biomedical applications.
Ostwald Ripening in an Oxide‐on‐Metal System
Authors: Michalak Natalia , Ossowski Tomasz , Miłosz Zygmunt , Prieto Mauricio J. , Wang Ying , Werwiński Mirosław , Babacic Visnja , Genuzio Francesca , Vattuone Luca , Kiejna Adam , Schmidt Thomas , Lewandowski Mikołaj 
Published: May 2022

AbstractOstwald ripening is a well‐known physicochemical phenomenon in which smaller particles, characterized by high surface energy, dissolve and feed the bigger ones that are thermodynamically more stable. The effect is commonly observed in solid and liquid solutions, as well as in systems consisting of supported metal clusters or liquid droplets. Here, evidence is provided for the occurrence of Ostwald ripening in an oxide‐on‐metal system which, in this case, consists of ultrathin iron monoxide (FeO) islands grown on Ru(0001) single‐crystal support. The results reveal that the thermally‐driven sintering of islands allows altering their fine structural characteristics, including size, perimeter length, defect density and stoichiometry, which are crucial, for example, from the point of view of heterogeneous catalysis.
Underwater Fast Bubble Generating on Pitaya Thorn and Enhanced Biomimetic Gas Collection
Authors: Zhong Lieshuang , Chen Huan , Zhu Lingmei , Zhang Lei , Wang Shaomin , Hou Yongping , Zheng Yongmei 
Published: April 2022

AbstractUnderwater bubble is vital to various applications and many technologies are applied for realizing efficient interfacial bubble generating. Here, the unique underwater bubble generating by the thorn of pitaya is reported. Extensive bubbles are generated underwater within few seconds on the thorn surface. Microbumps and dual‐scale ribs grow on the thorn surface, constructing the unique dual‐scale groove configuration along the thorn surface. Microbumps equip groove with width gradient. The mechanism of how geometric configuration of groove and surface wettability affect the bubble generating is investigated. Bioinspired study shows that groove configuration can generate bubble within 2 ms by reassembling gas column within groove, which lowers the energy barrier of bubble generating and accelerated gas molecular diffusion toward bubble. Dual‐scale groove is beneficial for strengthening surface hydrophobicity and is favorable for reassembling. Besides, width gradient induces the discrepancy of interface curvature along the groove and further accelerates the bubble generating. Accordingly, the dual‐scale gradient groove can speed up bubble generating by ≈800%. Especially, the biomimetic combinational groove can realize enhanced underwater gas collection. This research reveals a new mechanism of fast bubble generating which is of great potential for the applications based on underwater bubbles.
Improvement of Photovoltaic Performance of Cu2ZnSn(S,Se)4 Solar Cells by Modification of Back Electrode Interface with Amorphous Boron Nitride
Authors: Wang Ting , Yao Bin , Li Yongfeng , Ding Zhanhui , Zhang Jiayong , Wang Chunkai , Liu Jia 
Published: April 2022

AbstractAn amorphous boron nitride (aBN) layer is inserted between Cu2ZnSn(S,Se)4 (CZTSSe) films and Mo back electrode of CZTSSe solar cell by magnetron sputtering to mitigate the carrier recombination at back interface by tuning energy band alignment and suppressing formation of secondary phases and Mo(S,Se)2. The effect of the aBN layer on power conversion efficiency (PCE) of CZTSSe solar cell is investigated by numerical simulation and experiment. It is found that PCE is greatly improved via the insertion of suitable thick aBN layer, which is attributed to increased open‐circuit voltage (VOC) and fill factor (FF). By quantitative analysis, it is deduced that the increased VOC originates mainly from decrease in reverse saturation current density (J0), followed by increase in shunt resistance (RSh), and the increased FF is mainly due to the decreased J0, followed by increased RSh and decreased photogenerated current density (JL). By optimizing aBN thickness through tuning sputtering time, the PCE increases from 8.68% of CZTSSe solar cell without the aBN layer to 9.51% of the CZTSSe solar cell with aBN layer. The influence mechanism of the aBN layer on the PCE is suggested by analyzing quantitatively the effect of the aBN layer on JL and electrical parameters.
Intercalation‐Driven Defect‐Engineering of MoS2for Catalytic Transfer Hydrogenation
Authors: Shi Yanghao , Zhang Wenbiao , Tan Jingwen , Yan Tianlan , Jia Yingshuai , Wang Zhiyuan , Tang Yi , Gao Qingsheng 
Published: April 2022

AbstractCrystal defects are pivotal to boosting catalytic performance and an in‐depth understanding of the working mechanism of transition‐metal chalcogenides (TMDs), but their facile and controllable engineering are yet challenging. Herein, a new route is introduced to engineer defects on MoS2via in situ intercalation during its hydrothermal preparation, accomplishing the efficient catalytic transfer hydrogenation (CTH) of nitroarenes. The combination of multiple structural characterizations demonstrates that the density of S defects can be tuned by the intercalation of ammonium and dimethylamine cations due to lattice strain/distortion and ligand substitution. As a proof of concept, the defect‐dependent catalytic performance is evidenced in the CTH of nitrobenzene with isopropanol, highlighting the significance of coordinatively unsaturated Mo sites in generating reactive chemisorbed H for subsequent hydrogenation. The good efficiency of defective MoS2within a broad substrate scope further verifies the promise of the intercalation‐driven defect‐engineering strategy for designing TMDs‐based catalysts.
Ti3C2Tx MXene as Electrocatalyst for Designing Robust Glucose Biosensors
Authors: Kumar Rajesh , Singh Lakhveer 
Published: April 2022

Abstract2D transition metal carbides, nitrides, and carbo‐nitrides, known as MXenes, have emerged as a versatile class of nanomaterials. MXenes are hailed as remedies to a plethora of global problems. Some of the remarkable ideal properties of MXenes that can transcend the boundaries of current technology, particularly in the field of sensors, include metal‐like high electrical conductivity, quantum confinement effects, electro‐optic properties, large surface area, ease of functionalization, and surface modifications. This review highlights current breakthroughs in fundamental knowledge, synthesis, and attributes of MXene‐based materials for glucose biosensing applications. The effects of various secondary inorganic and organic compounds, such as polymers, carbonaceous materials, transition metal oxides, and metallic nanoparticles on the biosensing performance of the MXenes, analyzed through electrochemical, optical, and noninvasive techniques, toward glucose have been investigated and reviewed. The primary purpose of this review article is thus to give an up‐to‐date critical analysis of MXene composite‐based glucose biosensors, as well as recent achievements and challenges in the synthesis, fabrication of related devices, and novel biosensing approaches. Lastly, the current research challenges and future research potential for MXenes in electrochemical glucose sensing are also addressed.
Bio‐Inspired Macromolecular Ordering of Elastomers for Enhanced Contact Electrification and Triboelectric Energy Harvesting
Authors: Šutka Andris , Lapčinskis Linards , Verners Osvalds , Ģērmane Līva , Smits Krisjanis , Pludons Arturs , Gaidukovs Sergejs , Jerāne Ilze , Zubkins Martins , Pudzs Kaspars , Sherrell Peter Cameron , Blums Juris 
Published: April 2022

AbstractTriboelectrification of polymers enables mechanical energy harvesting in triboelectric generators, droplet generators, and ferroelectrets. Herein, triboelectric polymers, inspired by the ordering in spider‐silk, with strongly enhanced contact electrification are presented. The ordering in polyether block amide (PEBA) is induced by the addition of inorganic goethite (α‐FeOOH) nanowires that form H‐bonds with the elastomeric matrix. The addition of as little as 0.1 vol% of α‐FeOOH into PEBA increases the surface charge by more than order of magnitude (from 0.069 to 0.93 nC cm–2). The H‐bonds between α‐FeOOH and PEBA promote the formation of inclusions with higher degree of macromolecular ordering, analogous to the structure of spider silk. The formation of these inclusions is proven via nanoindentation hardness measurements and correlated with H‐bond‐induced chemical changes by Fourier transform infrared spectroscopy and direct scanning calorimetry. Theoretical studies reveal that the irregularity in hardness provides stress accumulation on the polymer surface during contact‐separation. Subsequent molecular dynamic studies demonstrate that stress accumulation promotes the mass‐transfer mechanism of contact electrification. The proposed macromolecular structure design provides a new paradigm for developing materials for applications in mechanical energy harvesting.
Synergistic Structural Engineering of Tunnel‐Type Polyantimonic Acid Enables Dual‐Boosted Volumetric and Areal Lithium Energy Storage
Authors: Yong Kai , Fang Haoyu , Wang Boya , Qiu Xiaoling , Wu Kaipeng , Wang Qian , Zhang Yun , Wu Hao 
Published: April 2022

AbstractTunnel‐structured polyantimonic acid (PAA) is an intriguing high‐capacity anode candidate for alkali‐metal‐ion storage; however, the awful electroconductivity of PAA (≈10–10 S cm–1) normally requires coupling with large‐surface‐area conductive substrate (e.g., graphene), conversely leading to poor scalability, ultralow density, and execrable volumetric energy. Synergistic structural engineering of PAA via bulk‐phase ion substitution and incorporation with low‐cost flake graphite (FG) is presented here to construct composite electrodes for lithium‐storage. The full‐occupation of Mn2+ into the tunnel‐centers of PAA synchronously improves its bulk conductivity (≈10–5 S cm–1) and true density (4.58 g cm–3), whilst less than 20% volume expansion of PAA is consequently achieved by FG confinement with enhanced multielectron‐reaction kinetics, unveiled by ex/in situ techniques. Besides delivering considerable volumetric capacity (>1200 mAh cm–3 at 0.1 A g–1), thus‐fabricated high‐tap‐density composite favors the construction of conducting additive‐free, high‐loading thick electrodes (>6.0 mg cm–2), exhibiting dual‐boosted areal/volumetric capacities (4.2 mAh cm–2/743 mAh cm–3), and fast‐charging capability (75% capacity charged within ≈13 min). Moreover, 3D‐printed composite electrodes with tunable shape and mass‐loading are also implemented to showcase impressive areal/volumetric Li+‐storage performance. Paring with high‐loading and high‐compact‐density LiCoO2 cathodes (e.g., 18.0 mg cm–2/3.53 g cc–1), full‐cells achieve remarkable electrode‐level areal‐/volumetric‐energy‐densities beyond 7.0 mWh cm–2/850 Wh L–1cathode+anode.
3D bioprinted organ‐on‐chips
Authors: Rahmani Dabbagh Sajjad , Rezapour Sarabi Misagh , Birtek Mehmet Tugrul , Mustafaoglu Nur , Zhang Yu Shrike , Tasoglu Savas 
Published: May 2022

AbstractOrgan‐on‐a‐chip (OOC) platforms recapitulate human in vivo‐like conditions more realistically compared to many animal models and conventional two‐dimensional cell cultures. OOC setups benefit from continuous perfusion of cell cultures through microfluidic channels, which promotes cell viability and activities. Moreover, microfluidic chips allow the integration of biosensors for real‐time monitoring and analysis of cell interactions and responses to administered drugs. Three‐dimensional (3D) bioprinting enables the fabrication of multicell OOC platforms with sophisticated 3D structures that more closely mimic human tissues. 3D‐bioprinted OOC platforms are promising tools for understanding the functions of organs, disruptive influences of diseases on organ functionality, and screening the efficacy as well as toxicity of drugs on organs. Here, common 3D bioprinting techniques, advantages, and limitations of each method are reviewed. Additionally, recent advances, applications, and potentials of 3D‐bioprinted OOC platforms for emulating various human organs are presented. Last, current challenges and future perspectives of OOC platforms are discussed.
The Achieved Capabilities Questionnaire for Community Mental Health (ACQ‐CMH): A consumer‐based measure for the evaluation of community mental health interventions
Authors: Sacchetto Beatrice , Ornelas José , Calheiros Maria M. 
Published: May 2022

AbstractThe capabilities approach offers a multidimensional, ecological, and agent‐centered framework that may inspire models of intervention and evaluation. A growing number of measures grounded on the capabilities approach for outcome measurement are appearing. Regarding community mental health, new consumer‐valued measures—constructed in collaboration with consumers—are here considered crucial for a transformative shift. Meanwhile, new measurements need to provide psychometric evidence to enable proper choice and application. The Achieved Capabilities Questionnaire for Community Mental Health (ACQ‐CMH) was developed in collaboration with consumers of community mental health services. It aims to assess consumers' capabilities achieved through program support. The present paper shows advancements in the measure validation through a confirmatory factor analysis within a sample of community mental health consumers (N = 225). Reliability and construct‐related validity were also observed. A structural solution composed of five factors and 43 items revealed a better model fit than that obtained in a previous exploratory study. Findings support the reliability, sensibility, and both convergent and discriminant validity of using the ACQ‐CMH in the evaluation of community mental health interventions. The ACQ‐CMH offers a consumer‐valued framework with specific dimensions and indicators of capabilities for use in a routine service evaluation setting.
CAR‐T cell therapy targeting B cell maturation antigen is effective for relapsed/refractory multiple myeloma, including cases with poor performance status
Authors: Du Juan , Wei Runhong , Jiang Songfu , Jiang Hua , Li Lu , Qiang Wanting , He Haiyan , Shi Lin , Ma Qiuling , Yu Kang , Zhang Xiaoyuan , Ding Hanyi , Sun Xuedong , Xiang Fang , Zhu Lin , Cheng Zhi , Fu Weijun 
Published: April 2022

AbstractIn this open‐label, single‐arm, phase I/II clinical trial, we evaluated the efficacy of anti‐B cell maturation antigen (BCMA) chimeric antigen receptor (CAR)‐T cell (HDS269B) therapy in 49 relapsed/refractory multiple myeloma (RRMM) patients, including 20 with Eastern Cooperative Oncology Group (ECOG) grade 3–4. After HDS269B infusion (9 × 106 CAR+ cells/kg), 17 patients (34.69%, 11 ECOG 0–2, 6 ECOG 3–4) developed cytokine release syndrome [grade 1–2: 14 patients (28.57%); grade 3: 3 patients (6.12%)]. The objective response rate (ORR) was 77%, with a complete response (CR) achieved in 47%. Ongoing response >12 months occurred in 15 patients, and was extended beyond 38 months in one patient. The median progression‐free survival (PFS) and overall survival (OS) were 10 months (95% CI 5.3–14.7) and 29 months (95% CI 10.0–48.0), respectively. The PFS (12 months) and OS (18 months) rates were 41.64% and 62.76%, respectively. In patients with ECOG 0–2 and 3–4, ORR was 79.31% (23/29) and 75.0% (15/20) and PFS were 15 months (95% CI 5.4–24.6) and 4 months (95% CI 0–11.7), respectively. OS was not reached in ECOG 0–2 patients, but was 10.5 months (95% CI 0–22) in ECOG 3–4 patients. Single‐cell sequencing indicated that treatment efficacy might be related to mTORC1 signaling. Thus, HDS269B therapy is safe and effective for RRMM patients, even those with ECOG 3–4.
Unusual complications in the management of chronic lymphocytic leukemia
Authors: Gordon Max J. , Ferrajoli Alessandra 
Published: May 2022

AbstractChronic lymphocytic leukemia (CLL) is a common, indolent disease that typically presents with a proliferation of mature, immunologically dysfunctional CD5+ B‐cells which preferentially occupy the bone marrow, peripheral blood and lymphoid organs. Immune dysfunction leads to an increase in autoimmune diseases which occur in approximately 10% of patients with CLL. Autoimmune cytopenias are the most common, but other organs may be affected as well. The treatment of these conditions typically depends on the extent of CLL and severity of symptoms, but generally consists of CLL‐directed therapies, immunosuppression or both. CLL may also infiltrate extranodal sites in the body. Symptomatic extranodal CLL or extranodal disease which threatens normal organ function is an indication for initiation of CLL‐directed therapy. The following review summarizes autoimmune and extranodal complications that can occur in patients with CLL and our suggested approach to their treatment.
The role of body height as a co‐factor of excess weight in Switzerland
Authors: Rickenbacher Marc , Gültekin Nejla , Stanga Zeno , Bender Nicole , Staub Kaspar , Wells Jonathan C. , Matthes Katarina L. , Reber Emile 
Published: April 2022

AbstractObjectExcess weight (Body Mass Index [BMI] ≥25.0 kg/m2) is a major health issue worldwide, including in Switzerland. For high‐income countries, little attention has been paid to body height in context of excess weight. The aim of this study is to assess the importance of body height as a co‐factor for excess weight in multiple large nationwide data sets.Data and methodsIn this comparative study, we included the largest nationwide and population‐based studies in the fields of public health, nutrition and economics for Switzerland, as well as data of the medical examination during conscription for the Swiss Armed Forces, which contained information on BMI and, if possible, waist‐to‐height‐ratio (WHtR) and waist‐to‐hip‐ratio (WHR).ResultsThe multinomial logistic regressions show that the probability of belonging to the excess weight category (BMI ≥25.0 kg/m2) decreased with increasing height in both sexes inall contemporary data sets. This negative association was shown to be constant, only among conscripts measured in the 1870s the association was positive, when increasing height was associated with a higher BMI. The negative association not only emerge in BMI, but also in WHtR and WHR.ConclusionOur results emphasize the importance of body height as a co‐factor of excess weight, suggesting a clear negative association between height and BMI, WHtR and WHR. Evidence indicates that both early‐life environmental exposures and alleles associated with height may contribute to these associations. This knowledge could serve as further starting points for prevention programs in the field of public health.