bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mapping of neuroinflammation-induced hypoxia in the spinal cord using optoacoustic imaging
Authors: Ramos-Vega Marta , Kjellman Pontus , Todorov Mihail Ivilinov , Kylkilahti Tekla Maria , Bäckström B. Thomas , Ertürk Ali , Madsen Chris Denis , Lundgaard Iben 
Published: April 2022

AbstractRecent studies suggest that metabolic changes and oxygen deficiency in the central nervous system play an important role in the pathophysiology of multiple sclerosis (MS). In our present study, we investigated the changes in oxygenation and analyzed the vascular perfusion of the spinal cord in a rodent model of MS. We performed multispectral optoacoustic tomography of the lumbar spinal cord before and after an oxygen enhancement challenge in mice with experimental autoimmune encephalomyelitis (EAE), a model for MS. In addition, mice were transcardially perfused with lectin to label the vasculature and their spinal columns were optically cleared, followed by light sheet fluorescence microscopy. To analyze the angioarchitecture of the intact spine, we used VesSAP, a novel deep learning-based framework. In EAE mice, the spinal cord had lower oxygen saturation and hemoglobin concentration compared to healthy mice, indicating compromised perfusion of the spinal cord. Oxygen administration reversed hypoxia in the spinal cord of EAE mice, although the ventral region remained hypoxic. Additionally, despite the increased vascular density, we report a reduction in length and complexity of the perfused vascular network in EAE. Taken together, these findings highlight a new aspect of neuroinflammatory pathology, revealing a significant degree of hypoxia in EAE in vivo that is accompanied by changes in spinal vascular perfusion. The study also introduces optoacoustic imaging as a tractable technique with the potential to further decipher the role of hypoxia in EAE and to monitor it in MS patients.
Effects of High-Intensity Interval Training in School on the Physical Performance and Health of Children and Adolescents: A Systematic Review with Meta-Analysis
Authors: Bauer Nikolai , Sperlich Billy , Holmberg Hans-Christer , Engel Florian A. 
Published: April 2022

Abstract
Background
Performance of high-intensity interval training (HIIT) by children and adolescents improves physical and health-related fitness, as well as cardiometabolic risk factors.

Objectives
To assess the impact of HIIT performed at school, i.e. both in connection with physical education (intra-PE) and extracurricular sports activities (extra-PE), on the physical fitness and health of children and adolescents.

Methods
PubMed and SPORTDiscus were searched systematically utilizing the following criteria for inclusion: (1) healthy children and adolescents (5–18 years old) of normal weight; (2) HIIT performed intra- and/or extra-PE for at least 5 days at an intensity ≥ 80% of maximal heart rate (HRmax) or peak oxygen uptake (VO2peak) or as Functional HIIT; (3) comparison with a control (HIIT versus alternative interventions); and (4) pre- and post-analysis of parameters related to physical fitness and health. The outcomes with HIIT and the control interventions were compared utilizing Hedges’ g effect size (ES) and associated 95% confidence intervals.

Results
Eleven studies involving 707 participants who performed intra-PE and 388 participants extra-PE HIIT were included. In comparison with the control interventions, intra-PE HIIT improved mean ES for neuromuscular and anaerobic performance (ES jump performance: 5.89 ± 5.67 (range 1.88–9.90); ES number of push-ups: 6.22 (range n.a.); ES number of sit-ups: 2.66 ± 2.02 (range 1.24–4.09)), as well as ES fasting glucose levels (− 2.68 (range n.a.)) more effectively, with large effect sizes. Extra-PE HIIT improved mean ES for neuromuscular and anaerobic performance (ES jump performance: 1.81 (range n.a.); ES number of sit-ups: 2.60 (range n.a.)) to an even greater extent, again with large effect sizes. Neither form of HIIT was more beneficial for parameters related to cardiorespiratory fitness than the control interventions.

Conclusion
Compared to other forms of exercise (e.g. low-to-moderate-intensity running or walking), both intra- and extra-PE HIIT result in greater improvements in neuromuscular and anaerobic performance, as well as in fasting levels of glucose in school children.
Proximal Hamstring Tendon Avulsions: A Survey of Orthopaedic Surgeons’ Current Practices in the Nordic Countries
Authors: Laszlo Sofia , Nilsson Martin , Pihl Elsa , Mattila Ville M. , Schilcher Jörg , Sköldenberg Olof , Frihagen Frede , Jonsson Kenneth B. 
Published: April 2022

Abstract
Background and purpose
Evidence guiding the decision on whether to treat proximal hamstring tendon avulsions (PHA) operatively or non-operatively is very limited. The aim of this study was to identify the current practices and the rationale behind PHA treatment decisions in the Nordic countries.

Methods
A survey was sent to orthopaedic surgeons in Sweden, Norway, Finland and Denmark. The study population consisted of responding surgeons with exposure to surgical treatment of PHA (n = 125). The questions covered surgeon and unit characteristics, and surgeons’ understanding of the evidence for treatment, and they explored which patient and injury factors influence treatment allocation.

Results
Although some surgeons indicated a preference for one of the treatments, 84% stated that the treatment decision was based on patient and injury-related factors. Severe obesity, drug abuse, a sedentary lifestyle, age > 60 years and delayed diagnosis (> 6 weeks) were considered contraindications to surgical treatment. Also, there was agreement that patients expressing a preference for non-operative treatment should not be operated. Complete avulsions with tendon dislocation ≥ 2–3 cm on MRI were relative indications for surgical treatment.
The majority of surgeons did not believe that operatively treated patients did better than non-operatively treated patients and experienced that patients, generally, were satisfied with the treatment result, regardless of the type of treatment. Most surgeons had experienced significant complications to operative treatment.

Conclusion
Current practices varied among different units, and despite the lack of evidence for their prognostic value, several factors were inconsistently being used as decision modifiers when selecting patients for surgical treatment.
M2-like macrophages transplantation protects against the doxorubicin-induced heart failure via mitochondrial transfer
Authors: Liu Yihai , Wu Mingyue , Zhong Chongxia , Xu Biao , Kang Lina 
Published: April 2022

Abstract

Aims
The alternatively activated macrophages have shown a cardioprotective effect in heart failure. However, the effect of M2 adoptive transfer in non-ischemic heart failure is unknown. In this study, we evaluated the efficacy of M-CSF plus IL-4 induced M2-like macrophages transplantation in doxorubicin-induced cardiotoxicity.

Methods

Bone marrow mononuclear cells were polarized as CCR2
+
CD206
+
M2-like macrophages by a combination of M-CSF plus IL-4 treatment. C57BL/6 mice received a single intraperitoneal injection of doxorubicin (15 mg/kg). The treatment group were treated with M2-like macrophages (1 × 10^6 cells per mouse; i.v.) once a week for 2 weeks. After 3 weeks, we examined the percentage of resident cells and cardiac function. Furthermore, we evaluated cardiac fibrosis, cardiomyocyte apoptosis and circulating inflammatory factors. Finally, we investigated the mitochondria transfer in vitro in a direct and indirect co-culture conditions.

Results
Cardiac function was significantly improved in doxorubicin-induced heart failure by adoptive transfer of M2-like macrophages. Besides, M2-like macrophages treatment attenuated cardiac fibrosis and cardiomyocyte apoptosis, as well as increased the level of circulating IL-4 and Th2 response. In vitro, M2-like macrophages could transfer mitochondria to injured cardiomyocytes in a direct and indirect way.

Conclusions
In our study, adoptive transfer of M2-like macrophages could protect against the doxorubicin-induced cardiotoxicity, which may be partly attributed to mitochondria transfer. And M2-like macrophages transplantation could become a treatment for non-ischemic heart failure in the clinical practice.

Graphical Abstract
The effect of co-ethnic social capital on immigrants' labor market integration: a natural experiment
Authors: Gërxhani Klarita , Kosyakova Yuliya 
Published: April 2022

AbstractEmpirically identifying the causal effect of social capital on immigrants’ economic prospects is a challenging task due to the non-random residential sorting of immigrants into locations with greater opportunities for prior or co-ethnic connections. Our study addresses this selection-bias issue by using a natural-experimental dataset of refugees and other immigrants who were exogenously allocated to their first place of residence by German authorities. This unique opportunity allows us to make an important methodological contribution to the predominantly observational knowledge about immigration and co-ethnic social capital. Although a growing body of migration studies in economics and sociology stresses the importance of social networks for migrants’ labor market integration, our results show little evidence of a causal effect of social networks themselves. Being part of a larger co-ethnic community per se does not accelerate immigrants’ labor market success except for the migrants who use the resources embedded in their social contacts when looking for a job. We conclude that further methodological advancements can be achieved by embracing recent technological developments and by combining different methods to increase both internal and external validity of findings in migration studies.
Cardiac mechanisms for low aerobic power in anthracycline treated, older, long-term breast cancer survivors
Authors: Beaudry Rhys I. , Haykowsky Mark J. , MacNamara James P. , Tucker Wesley J. , Rao Roshni , Haley Barbara , Sarma Satyam 
Published: April 2022

AbstractBreast cancer survivors have reduced peak aerobic capacity (VO2peak) which may be related to latent or lingering chemotherapy induced cardiac damage. Nine, older (67 ± 3 years), long-term survivors (9.8 years) of anthracycline based chemotherapy and age- and sex-matched healthy controls were recruited and tested to determine whether: i) VO2peak remains reduced in long-term survivorship; and ii) reductions in VO2peak are due to cardiac dysfunction. VO2peak was significantly reduced in breast cancer survivors relative to healthy controls (15.9 ± 2.0 vs 19.9 ± 3.1 ml/kg/min, p = 0.006), however the heart rate and stroke volume responses to exercise were normal (heart rate reserve; 88 ± 9 vs 85 ± 10 bpm, p = 0.62: stroke volume reserve; 13 ± 6 vs 13 ± 9 ml,p = 0.94). These findings indicate low-normal ventricular size in long-term breast cancer survivors, but normal reserve function.
Learning from success stories when using eLearning and bLearning modalities in higher education: a meta-analysis and lessons towards digital educational transformation
Authors: Galvis Álvaro H. , Carvajal Diógenes 
Published: April 2022

AbstractThis work seeks to support scholars interested in non-face-to-face modalities of higher education in making decisions about the use of digital and educational technologies (DET) to promote educational transformation (ET) in the context of their organizations. This organizational change deals with the implementation of technology-based flexible educational practices, focused on helping students develop competencies of interest for their personal and professional growth. With this in mind, in 2018 we identified and followed six leading higher education institutions on three continents that, for years, have carried out educational innovation experiences with the support of technology. Two of the analyzed experiences make use of eLearning, another of bLearning, and the others combine eLearning and bLearning as a complement to the face-to-face modality. The meta-analysis of the cases, carried out in 2019, followed suggestions from (Stake in The art of case study research, Sage Publications Inc., 1995) as well as from qualitative research that seeks to understand what is behind the cases from three dimensions: education, technology, organization. For each one, we determined what they do, how they do it, and what success factors must be considered. As the data was collected before the 2020 pandemic and this issue produced structural imbalances in society and in higher education, it was considered pertinent, at the end of 2020, to check the pulse of the ET mediated with DET in three of the six institutions studied. The purpose was to refine the findings of the meta-analysis and learn from the decisions made in the situation of forced change in environments, means, and strategies to continue providing quality higher education.
Portevin–Le Chatelier effect: modeling the deformation bands and stress-strain curves
Authors: Mäkinen Tero , Ovaska Markus , Laurson Lasse , Alava Mikko J. 
Published: April 2022

AbstractIn the Portevin–Le Chatelier (PLC) effect sample plastic deformation takes place via localized bands. We present a model to account for band dynamics and the variability the bands exhibit. The approach is tuned to account for strain hardening and the strain-rate dependence for the case of so-called type A (propagating) bands. The main experimental features of the fluctuations are a reduction with strain and increase with the strain rate which is reproduced by a model of plastic deformation with Dynamic Strain Aging, including disorder as a key parameter. Extensions are discussed as are the short-comings in reproducing detailed avalanche statistics.
Principle and performance of multi-frequency and multi-GNSS PPP-RTK
Authors: Li Xingxing , Wang Bo , Li Xin , Huang Jiaxin , Lyu Hongbo , Han Xinjuan 
Published: April 2022

AbstractPPP-RTK which takes full advantages of both Real-Time Kinematic (RTK) and Precise Point Positioning (PPP), is able to provide centimeter-level positioning accuracy with rapid integer Ambiguity Resolution (AR). In recent years, with the development of BeiDou Navigation Satellite System (BDS) and Galileo navigation satellite system (Galileo) as well as the modernization of Global Positioning System (GPS) and GLObal NAvigation Satellite System (GLONASS), more than 140 Global Navigation Satellite System (GNSS) satellites are available. Particularly, the new-generation GNSS satellites are capable of transmitting signals on three or more frequencies. Multi-GNSS and multi-frequency observations become available and can be used to enhance the performance of PPP-RTK. In this contribution, we develop a multi-GNSS and multi-frequency PPP-RTK model, which uses all the available GNSS observations, and comprehensively evaluate its performance in urban environments from the perspectives of positioning accuracy, convergence and fixing percentage. In this method, the precise atmospheric corrections are derived from the multi-frequency and multi-GNSS observations of a regional network, and then disseminated to users to achieve PPP rapid AR. Furthermore, a cascade ambiguity fixing strategy using Extra‐Wide‐Lane (EWL), Wide-Lane (WL) and L1 ambiguities is employed to improve the performance of ambiguity fixing in the urban environments. Vehicle experiments in different scenarios such as suburbs, overpasses, and tunnels are conducted to validate the proposed method. In suburbs, an accuracy of within 2 cm in the horizontal direction and 4 cm in the vertical direction, with the fixing percentage of 93.7% can be achieved. Compared to the GPS-only solution, the positioning accuracy is improved by 87.6%. In urban environments where signals are interrupted frequently, a fast ambiguity re-fixing can be achieved within 5 s. Moreover, multi-frequency GNSS signals can further improve the positioning performance of PPP-RTK, particularly in the case of small amount of observations. These results demonstrate that the multi-frequency and multi-GNSS PPP-RTK is a promising tool for supporting precise vehicle navigation.
Risk stratification of sudden cardiac death in Brugada syndrome: an updated review of literature
Authors: Darar Charmake , Mohammed El-Azrak , Mohammed Boutaybi , Noha El Ouafi , Zakaria Bazid 
Published: April 2022

AbstractBrugada syndrome is a rare but serious inherited heart disease that causes sudden cardiac death by polymorphic ventricular tachycardia or ventricular fibrillation. It is an autosomal dominant genetic disease that usually occurs in patients in their forties with a structurally normal heart. Electrically, it manifests by ST elevation segment ≥ 2 mm of at least one right precordial lead (V1 and/or V2). Stratification of sudden cardiac death in Brugada syndrome is not always easy and constitutes a real challenge for the practitioner. In this review, we will present the current state of knowledge for arrhythmic risk stratification and the prevention of sudden cardiac death that can result from this syndrome.
An initial evaluation of narrative exposure therapy as a treatment of posttraumatic stress disorder among Sudanese refugees in Cairo, delivered by lay counselors
Authors: Ellis Kate , Jones F. 
Published: April 2022

Abstract
Background
The growing worldwide refugee crisis highlights the needs for increased access to mental health services, including in the large urban cities in the Middle East to which refugees are frequently displaced and in which access to such services is limited. The current study offers an initial evaluation of narrative exposure therapy as a treatment for posttraumatic stress disorder among Sudanese refugees in Cairo, delivered by lay counselors. Sudanese refugees with no prior background in counseling were given 27 h of training in narrative exposure therapy. They then delivered this to seven members of the same refugee community with a diagnosis of posttraumatic stress disorder at a local community center, and this was evaluated using a pre-post design and a focus-group with the intervention recipients.

Results
Despite the small sample size, over the course of the intervention there was significant decrease in trauma and anxiety symptoms, and a close to significant decrease in depression. Moreover, the focus group participants generally spoke positively about their experiences.

Conclusions
To the best of the authors’ knowledge, this is the first study to examine the viability of lay counselors delivering narrative exposure therapy to refugees with posttraumatic stress disorder in a complex urban setting. The findings suggest that this approach has promise and support the case for a randomized control trial of narrative exposure therapy delivered in this manner in such a setting.
Using economic evaluations in implementation science to increase transparency in costs and outcomes for organizational decision-makers
Authors: Saldana Lisa , Ritzwoller Debra P. , Campbell Mark , Block Eryn Piper 
Published: April 2022

Abstract
Background
Economic evaluations frequently are utilized to compare the value of different interventions in medicine and health in concrete terms. Implementation science also would benefit from the incorporation of economic evaluations, but such studies are rare in the literature. The National Cancer Institute has supported a special collection of articles focusing on economic evaluations in implementation science. Even when interventions are supported by substantial evidence, they are implemented infrequently in the field. Implementation costs are important determinants for whether organizational decision-makers choose to adopt an intervention and whether the implementation process is successful. Economic evaluations, such as cost-effectiveness analyses, can help organizational decision-makers choose between implementation approaches for evidence-based interventions by accounting for costs and succinctly presenting cost/benefit tradeoffs.

Main text
This manuscript presents a discussion of important considerations for incorporating economic evaluations into implementation science. First, the distinction between intervention and implementation costs is presented, along with an explanation of why the comprehensive representation of implementation costs is elusive. Then, the manuscript describes how economic evaluations in implementation science may differ from those in medicine and health intervention studies, especially in terms of determining the perspectives and outcomes of interest. Finally, referencing a scale-up trial of an evidence-based behavioral health intervention, concrete case examples of how cost data can be collected and used in economic evaluations targeting implementation, rather than clinical outcomes, are described.

Conclusions
By gaining a greater understanding of the costs and economic impact associated with different implementation approaches, organizational decision-makers will have better transparency for future replication and scale-up. The use of economic evaluations can help to advance this understanding and provide researchers, purveyors or third-party intermediaries, and organizational decision-makers with essential information to facilitate implementation.
Computational and pharmacokinetics studies of 1,3-dimethylbenzimidazolinone analogues of new proposed agent against Alzheimer's disease
Authors: Ajala Abduljelil , Uzairu Adamu , Shallangwa Gideon Adamu. , Abechi Stephen Eyije. 
Published: April 2022

Abstract
Background
Alzheimer's disease (AD) is a multifactorial disorder that gradually destroys wisdom and memory skills. Currently, this disease can only be treated palliatively. However, the molecular mechanisms underlying this condition remain elusive. Therefore, these treatments are inadequate. Current medications can only increase patient warning signs. Chemical structures were drawn using Chemsketch software. Spartan’14 software was used to optimize the structures using density functional theory (DFT). The PaDEL software was used to generate the descriptors. The genetic function algorithm (GFA) and multi-linear regression (MLR) approaches were used to generate the QSAR model.

Results
In the present study, we performed a computational investigation, molecular docking, and pharmacokinetics analysis of 1,3-dimethylbenzimidazolinone derivatives. The descriptors generated in the model are AATS7i, MATS5p, SpMin7_Bhe, and GATS6c. Compounds 13 and 21 have the best binding scores, 11.2 kcal/mol and 10.8 kcal/mol, respectively, and optimal protein–ligand interactions with AChE. These compounds have brilliant pharmacokinetic and physicochemical properties.

Conclusions
The model was validated and found to have good internal and external assessment parameters: R2 = 0.937, $$R_{{{\text{adj}}}}^{2}$$

R

adj

2

= 0.863, $$Q_{{{\text{cv}}}}^{2}$$

Q

cv

2

= 0.788, $$R_{{{\text{test}}}}^{2}$$

R

test

2

= 0.756, LOF = 0.0268, $$cR_{{\text{p}}}^{2}$$

c

R

p

2

= 0.677. In summary, these data suggested that compounds 13 and 21 are promising multifunctional agents against AD.