bluuebunny/crossref_metadata_2025_split huggingface dataset:
Robot Grasping in Random Scenarios Based on hybrid optimization algorithm (MR-GPD)
Authors: Zhnag Songsong , huang Haisong , Huang Dong , Wei Jianan 
Published: April 2022

Abstract
Robot grasping technology is favored by scientific researchers because of its importance in the field of robotics and its prospects. The main challenge of robotic grasping is to design an effective grasping detection algorithm for accurate grasping of the robot. Recently, various robotic grasping techniques have been proposed to improve the grasping performance of the robot. However, for random objects in an unstructured environment, even if accurate target classification is performed, multiple targets may overlap, which leads to a decline in the grasping performance of many robot grasping methods and cannot meet the accuracy requirements. To solve this problem, we propose an innovative grasping detection algorithm, which we call MR-GPD. MR-GPD is based on the robot grasping gesture detection algorithm (GPD), embeds the Mask-RCNN deep learning model to classify and segment the grasped target, then combine the results of target segmentation to construct a grasping candidate screening mechanism to evaluate and filter the outputted grasping candidates, and retain the best grasping candidate plan in the planned grasping task. To meet the requirements of the robot's actual grasping task, an improved Mask-RCNN neural network model is proposed, the speed and accuracy of target segmentation in the actual grasping process of the robot are improved, and the accuracy of the model reaches 97.5%. In this article, we conducted experimental evaluations through experimental tests and Baxter robots. The experimental results show that the method has a good grasp effect on randomly placed objects in unstructured environment, and the average success rate is about 91.2%, it reveals the feasibility of our proposed MR-GPD method, which is expected to provide important information for robot grasping in unstructured environment.
Centrosomal Protein 55 increases chromosomal instability in ovarian cancer cells by controlling microtubule dynamics
Authors: Muhs Stefanie , Joosse Simon , Paraschiakos Themistoklis , Schaefer Paula , Windhorst Sabine 
Published: April 2022

Abstract
Background: Centrosomal Protein 55 (CEP55) exhibits different oncogenic activities; it regulates the PI3K-Akt-pathway, cellular abscission and chromosomal instability (CIN) in different types of cancer cells. While the mechanism of CEP55-controlled PI3K-Akt signaling and cellular abscission are well-understood, its role in CIN has not been elucidated yet. Thus, the focus of this study was to address this issue.Methods: PI3K-Akt signaling was analyzed by Western blotting and cellular abscission by microtubule (MT)-life cell imaging. CIN was investigated by analyzing chromosomal alignment as well as chromosome and micronuclei number. In addition, next generation sequencing was performed. CEP55 was down- and up-regulated by lentiviral approaches and recombinantly expressed in bacteria. MT-dynamics were analyzed by turbidity and pull down assays as well as by fluorescence microscopy. Results: Depletion of CEP55 in ovarian cancer cells decreased the CIN rate, increased spindle MT-dynamics and decreased spindle MT-stability. In addition, recombinant CEP55 accelerated MT-polymerization and attenuated cold-induced MT-depolymerization. To analyze a potential relationship between CEP55 controlled CIN and its impact on MT-dynamics, the CEP55 MT-binding peptides were identified and a mutant with deficient MT-binding activity re-expressed in CEP55 depleted cells. This mutant did not restore decreased CIN in CEP55 depleted cells.Conclusion: Our data, showing that re-expression of a CEP55 mutant with deficient MT-binding activity in CEP55-depleted cells did not restore the high CIN rate of control cells, indicate that CEP55 controls CIN by binding to MTs. This knowledge now provides the possibility to selectively interfere with CEP55 controlled CIN in cancer cells.
Preoperative aminotransferase to albumin ratio correlates with tumor characteristics and predicts outcome of hepatocellular carcinoma patients after curative hepatectomy: A multicenter study
Authors: Peng Wei , Shen Junyi , Dai Junlong , Leng Shusheng , Xie Fei , Zhang Yu , Ran Shun , Sun Xin , Wen Tianfu 
Published: April 2022

Abstract
Aims: This study aimed to evaluate the clinical significance of the preoperative aminotransferase to albumin ratio (AAR) in patients with hepatocellular carcinoma (HCC) after hepatectomy.Methods: From five hospitals, a total of 991 patients with HCC admitted between December 2014 and December 2019 were included as the primary cohort and 883 patients with HCC admitted between December 2010 and December 2014 were included as the validation cohort. The X-tile software was conducted to identify the optimal cut-off value of AAR.Results: In the primary cohort, the optimal cut-off value of the AAR was defined as 0.7 and 1.6, respectively. Compared to patients with AAR 0.7-1.6, those with AAR >1.6 showed significantly worse overall survival (OS) and RFS, whereas those with AAR <0.7 showed significantly better OS and RFS (all p<0.001). Pathologically, patients with AAR >1.6 had more aggressive tumour characteristics, such as larger tumour size, higher incidence of microvascular invasion, and severe histologic activity, and higher AFP level than patients with AAR <0.7. Consistently, the abovementioned clinical significance of AAR was confirmed in the validation cohort. Conclusions: A high AAR was significantly correlated with advanced tumours and severe hepatic inflammation, and a worse prognosis of HCC.
Fitness consequences of chronic exposure to different light pollution wavelengths in nocturnal and diurnal rodents
Authors: Vardi-Naim Hagar , Benjamin Ava , Sagiv Tali , Kronfeld-Schor Noga 
Published: April 2022

Abstract
Use of artificial at night (ALAN) exposes the world to continuously increasing levels and distribution of light pollution. Our understanding of the adverse effects of ALAN is based on observational or laboratory studies, and its effects are probably underestimated. Demonstration of direct experimental fitness consequences of ALAN is missing. We studied the effects of chronic light pollution at different wavelengths on fitness and stress hormone levels under semi-natural conditions in two closely related species: the nocturnal common spiny mouse (Acomys cahirinus) and the diurnal golden spiny mouse (Acomys russatus). Our results clearly demonstrate the adverse effects of ALAN exposure on fitness of both nocturnal and diurnal species, manifested by changes in cortisol levels and reproductive timing, reduced reproductive output and reduced survival, which differed between species and wavelengths. In A. russatus exposure to blue ALAN had the strongest effect on fitness, followed by white and yellow ALAN exposure. In A. cahirinus results are more complex and suggest it suffered from combined effect of ALAN and competition. Our research shows that light pollution presents a real threat to both nocturnal and diurnal species, affecting the species fitness directly and through its interspecific interactions. Worryingly, these effects are probably not specific to spiny mice. The clear adverse effects we documented, as well as the differences between wave lengths, contribute to our ability present science-based recommendations to decision makers regarding the use of artificial light at night. Such information and guidelines are highly important nowadays when lighting systems are being replaced to promote energy efficiency.
Scabies Outbreak Investigation and Its Risk Factors in Gumbichu District, East Shewa Zone, Central Ethiopia: Unmatched Case-Control Study
Authors: Balcha Fufa , Bizuneh Hailemichael , Hunduma Fufa 
Published: April 2022

Abstract
Introduction: Scabies is one of the common public health problems but neglected parasitic diseases caused by Sarcoptes scabiei var hominis. Global scabies prevalence was about a 204million cases with 0.21% of total disability-adjusted life years lost. In Ethiopia, scabies is common, especially during natural or man-made disasters. This study was aimed to investigate scabies suspected outbreak and risk factors in Gumbichu District, Central Ethiopia, 2021.Methods: A community-based unmatched case-control study among 96 participants (32 cases and 64 controls) was conducted in the Gumbichu district from July 1-20/2021. Data were collected using a structured questionnaire. Line-listed data were entered into Microsoft Excel for descriptive analyses. Multivariable logistic regression analysis was computed using SPSS version 25 to identify factors associated with scabies. The odds ratio of 95% CI and a p-value less than 0.05 were used to describe the strength of the association and statistical significance.Results: A total of 1231 scabies cases line listed with overall attack rate of 16/1,000 population. The mean age was 14 years, and most affected age group was 5–14 years. Frequency of shower per month [AOR (95% CI) = 6.51(1.26-33.54)], sleeping with scabies patient [AOR (95% CI) = 10.52(3.75-29.53)], contact history [AOR (95%) = 11.44(1.72-76.22)],family size ≥5 [AOR (95% CI) = 8.63(2.42-30.84)], and sharing clothes with scabies cases [AOR (95% CI) = 14.31(3.04-67.35)] were found to be determinant factors of scabies outbreak. Conclusion: Frequency of shower per month, contact history, sleeping with scabies case, family size ≥5, and sharing clothes with scabies case were associated with a high frequency of scabies. Therefore, it is recommended to raise awareness about the transmission, prevention, and control of scabies disease.
Finite element simulation of treatment with locking platefor distal fibula fractures
Authors: Li Yafeng , Yang Wei , Zhang Xi , Yu Cheng , Ji Zhengzhao , Sun Jie , Zhang Jing 
Published: April 2022

Abstract
In this study, an improved finite element model is applied to compare the biomechanical stability of plates with three different options in the treatment of distal fibula fractures. A CT scan of the knee to ankle segment of a volunteer was performed. A three-dimensional finite element model of the fibula was reconstructed based on the CT data. Three different loads (uni-pedal standing, torsion, and twisting) were applied, the same as in the experiments in the literature. The stresses and strains of the three options were compared under the same loads, using a 4-hole locking plate (Option A), a 5-hole locking plate (Option B), and a 6-hole locking plate (Option C) in a standard plate for lateral internal fixation. The simulation results show that all three options showed a stress masking effect. Option C had the best overall biomechanical performance and could effectively distribute the transferred weight. This is because option C has greater torsional stiffness and better biomechanical stability than options A and B, and therefore, option C is the recommended internal fixation method for distal fibula fractures. The finite element analysis method developed in this work is applicable to the stress analysis of fracture treatment options in other body parts.
A Review of Health Related Quality of Life in Pediatric Inflammatory Bowel Disease Patients
Authors: Ahmed Saad , Alam Sadia , Alsabri Mohammed 
Published: April 2022

Abstract
Background:Inflammatory bowel disease (IBD) is a chronic autoimmune condition that can have a wide range of symptoms and a taxing clinical course for pediatric patients. Although clinical symptoms like hematochezia, diarrhea, and abdominal pain are commonly addressed, health related quality of life (HRQOL) is often overlooked in patients with IBD and pediatric patients with chronic disease in general.Methods:We searched through peer-reviewed primary literature related to IBD and health related quality of life, and selected 11 articles from the PubMed database to be reviewed.Results: We found patients with IBD reported worse overall HRQOL than their healthy counterparts, but greater or comparable HRQOL relative to other sick pediatric patients, including those with gastroesophageal reflux disease and chronic constipation. Some factors associated with a reduced HRQOL include disease activity, age, fatigue, gender, psychological variables, and associated symptoms.Conclusion: Examining HRQOL can improve symptoms for these patients and chart better outcomes. Thus, HRQOL should be considered by practitioners when caring for pediatric IBD patients in a clinical setting. Further, more studies, particularly prospective cohort studies and those with large and diverse samples, should be conducted to examine HRQOL in pediatric patients with chronic disease. Findings from these studies can help elucidate clinical management and early psychosocial interventions in children to reduce disease burden.
Multi-layer silicon nanoparticle solar cells: Conceptual design and performance analysis
Authors: Mirnaziry Sayyed Reza , Shameli Mohammad Ali , Yousefi Leila 
Published: April 2022

Abstract
We investigate the concept of nanoparticle-based solar cells composed of a silicon nanoparticle stack acting as efficient light trapping absorbers to achieve novel inorganic configurations for ultrathin photovoltaics. We study the potential of using these inherently nanotextured structures in enhancing the light absorption. For this, a detailed optical analysis is performed to demonstrate the dependency of the typical structure to physical parameters including the number of particle layers, lattice structure and angle of incidence; these behavior are then compared with conventional silicon solar cells. We propose various configurations to apply these sub-micron particles as a p-n junction solar cell. We also compute the electrical performance of selected configurations. In doing so, key issues including the effect of contact points between nanoparticles and impact of loss are addressed. In the end, we show how SiO2 nanoparticles on top of the cell structure can enhance the photocurrent. The appropriate range of SiO2 particle size is also obtained for the typical cell structures.
Estimation of Runoff Using NRCS-CN Method: A Study from South India
Authors: Mohanan Sreelakshmy , Mohanan Dhanusree , Gogoi Dipjyoti , V Thangamani 
Published: April 2022

Abstract
The water resource on earth surface is circulated and attains different forms; of which runoff is a major component. The runoff in any area depends on the amount of precipitation, terrain, soil type and characteristic, slope, land use activity in that region and many other location specific factors. There are several methodologies adopted world wide to estimate the runoff; one important and widely used techniques is the NRCS-CN method. This method uses precipitation, soil group and land use as the major input factors. The present study is carried out in a watershed, named the Vannathangarai watershed, a part of Noyyal river basin, which is a tributary of River Cauvery, a major river draining through southern India. The study reveals that runoff is positively correlated with precipitation and is very high in areas with slope
Canonical General Relativity and Emergent Geometry
Authors: Tee Philip 
Published: April 2022

Abstract
Ising models of emergent geometry are well known to possess ground states with many of the desired features of a low dimensional, Ricci flat vacuum. Further, excitations of these ground states can be shown to replicate the quantum dynamics of a free particle in the continuum limit. It would be a significant next step in the development of emergent Ising models to link them to an underlying physical theory that has General Relativity as its continuum limit. In this work we investigate how the canonical formulation of General Relativity can be used to construct such a discrete Hamiltonian using recent results in discrete differential geometry. We are able to demonstrate that the Ising models of emergent geometry are closely related to the model we propose, which we term the Canonical Ising Model, and may be interpreted as an approximation of discretized canonical general relativity.
Automatic Landmark Detection of Human Back Surface from Depth Images via Deep Learning
Authors: Delgarmi Masumeh , Heravi Hamed , Jounghani Ali Rahimpour , Darabi Mobin , Ebrahimi Afshin , Shamsi Mousa 
Published: April 2022

Abstract
Studying human postural structure is one of the challenging issues among scholars and physicians. The spine is known as the central axis of the body, and due to various genetic and environmental reasons, it could suffer from deformities leading to physical dysfunction and correspondingly affecting people's quality of life. Radiography is the most common method for detecting these deformities; however, it frequently exposes the patient to X-rays and ionization and consequently increases cancer risk in patients particularly children and pregnant women.The purpose of this research is to provide an entirely safe and non-invasive method to examine the spiral structure and its deformities. Hence, it is attempted to find the exact location of anatomical landmarks on the human back surface, which provides useful and functional information about the status of the human postural structure to the physician. In this study, using Microsoft Kinect sensor, the depth images from the human back surface of 105 people were recorded and, our proposed approach – a deep convolution neural network- was used as a model to estimate the locations of anatomical landmarks. In network architecture, two learning processes, including landmark position and affinity between the two associated landmarks, are successively performed in two separate branches. This is a bottom-up approach; thus, the runtime complexity is considerably reduced, and then the resulting anatomical points are evaluated concerning manual landmarks marked by the operator as the benchmark. Our results showed 86.9% of PDJ and 80% of PCK that demonstrate more effectiveness compared to other methods.
Voluntary exercise attenuates mice anxiety after traumatic brain injury via inhibiting NLRP3 inflammasome activation
Authors: Hu Xiaoxuan , Ou Yuhang , Li Jiashuo , Sun Meiqi , Ge Qian , Pan Yongqi , Cai Zhenlu , Tan Ruolan , Wang Wenyu , An Jing , Lu Haixia , Wu Gang 
Published: April 2022

Abstract
Background: Psychological disorders, particularly the anxiety after traumatic brain injury (TBI) have received great attention both in clinical practice and experimental investigation. New therapeutic strategies are urgently required nowadays to improve mental condition of TBI patients. Neuroinflammation is the typical adaptive response that played important roles in psychiatric illness after brain tissue damage. Therefore, the immune-targeted therapies has aroused attention. Voluntary exercise has been considered as the most essential rehabilitative intervention following TBI. However, there were some experiments showed opposite effects, which varies with different time windows. Whether and when the voluntary exercise should be taken after TBI remain to be defined. The aim of the current study was to elucidate whether in-time voluntary exercise could improve the neurological recovery and reduce the anxiety of TBI mice by inhibiting the neuroinflammation via attenuating the activation of NLRP3 inflammasome.Methods: Kunming mice (8 weeks) were subjected to TBI and randomly divided into 4 groups One week voluntary wheel running (VWR) was applied to TBI mice soon after trauma - at 2nd day after injury. The neurofunction of TBI mice was detected by neurological severity score (NSS) and beam walking assay. Anxiety behavior was evaluated by open-field (OF) test and elevated plus maze (EPM) test. The cellular inflammatory signal, including IL-12, IFN-γ, CCL2, IL-10 and TGF-β, as well as the activation of microglia and NLRP3 inflammasome in the perilesional cortex were investigated.Results: After one week VWR, neurological function recovery was enhanced while the anxiety behavior of TBI mice was significantly eased. Accompanied with this, anti-inflammatory signaling, IL-10 in particular, greatly elevated. NLRP3 expression, caspase-1 activation and pro-inflammatory cytokines IL-1β/ IL-18 secretion were significantly inhibited. All these alterations were consistent with reduced microglia activation in the perilesional site and positively correlated with the weaken of anxiety behavior.Conclusion: In-time VWR could be a high potential therapeutic strategy for neuropsychiatric disorders following TBI by targeting neuroinflammation.
Two-part intertrochanteric femur fractures with bisection of the lesser trochanter: an irreducible fracture pattern
Authors: Hu Sun-jun , Chang Shi-Min , Du Shou-chao , Zhang Li-zhi , Xiong Wen-feng 
Published: April 2022

Abstract
Objective To introduce the clinical features of and surgical techniques for a rare type of irreducible pertrochanteric femur fracture pattern with bisection of the lesser trochanter. Methods From Jan 2017 to Dec 2019, 357 patients with per/intertrochanteric femur fractures underwent surgery by closed reduction and internal fixation, of whom 12 patients were indentified with rare preoperative imaging features, the lesser trochanter was almost equally bisected. The main fracture pathoanatomy of these cases included: The anterior fracture line passed along the intertrochanteric line to the medial lesser trochanter and bisected it into two equal parts from mid-level of the lesser trochanteric protrusion. The proximal part of the lesser trochanter connected to the head-neck fragment and attached by the psoas major tendon, while the distal part of the lesser trochanter connected to the femoral shaft and attached by the tendon of the iliac muscle.These fractures were irreducible by a closed maneuver and were reduced with limited assistance by some devices, and short intramedullary nails were used for fixation of these fractures. The characteristics of these fracture pathoanatomy, causes of irreducibility, intraoperative techniques and clinical outcomes were summarized. Function was evaluated clinically and radiographically after a minimum of 12 months of follow-up. Results All patients were followed up for an average of 14.2 ± 2.1 months. Clinical fracture union occurred at an average of 10.8 ± 1.5 weeks, while radiographic union occurred at an average of 12.7±1.2 weeks. No cut out of the helical blade was visible on radiographs. The average Parker-Palmer score was 6.9±1.3 (range, 5–9) at the last follow up, including 8 cases rated as excellent, 2 as good and 2 as fair. Conclusion Two-part pertrochanteric femur fractures with bisection of the lesser trochanter have an irreducible fracture pattern with cortical locking and soft tissue incarceration. Soft tissue release and short cephalomedullary nail fixation for this fracture pattern provide stable fixation and allow early exercise. This treatment appears to have excellent outcomes in the short and medium terms.
Bergenin exerts antitumor effects by promoting survivin degradation
Authors: Li Xiaoying , Gan Yu , Han Shuangze , Liao Jinzhuang , Zhou Li , Li Wei 
Published: April 2022

Abstract
Survivin is overexpressed in multiple human malignancies and correlated with poor prognosis. In this study, we found that survivin is highly expressed in non-small cell lung cancer (NSCLC) tissues, and depletion of survivin inhibits tumorigenesis of NSCLC cells. Moreover, our results showed that bergenin, a natural product, exhibits antitumor activity against NSCLC cells. Bergenin suppresses cell viability and colony formation in A549, H1299 and H460 cells, and reduces the protein level of survivin dose-dependently. The mechanism study revealed that bergenin inhibits the phosphorylation of survivin by regulating Akt/Wee1/CDK1 signaling pathway, thereby enhancing the interaction between survivin and E3 ligase Fbxl7. In addition, bergenin enhances the expression of cleaved-PARP and -caspase 3, which promotes apoptosis of NSCLC cells. The in vivo study showed that the tumor volume, weight, and the expression of Ki67 and survivin were decreased obviously in bergenin treated group. Overall, our data indicate that bergenin has a significant antitumor activity and is a promising agent with therapeutic potential for NSCLC.