bluuebunny/crossref_metadata_2025_split huggingface dataset:
Flops of any length, Gopakumar-Vafa invariants and 5d Higgs branches
Authors: Collinucci Andrés , De Marco Mario , Sangiovanni Andrea , Valandro Roberto 
Published: August 2022

Abstract
The conifold is a basic example of a noncompact Calabi-Yau threefold that admits a simple flop, and in M-theory, gives rise to a 5d hypermultiplet at low energies, realized by an M2-brane wrapped on the vanishing sphere. We develop a novel gauge-theoretic method to construct new classes of examples that generalize the simple flop to so-called length ℓ = 1, . . . , 6. The method allows us to naturally read off the Gopakumar-Vafa invariants. Although they share similar properties to the beloved conifold, these threefolds are expected to admit M2-bound states of higher degree ℓ. We demonstrate this through our computations of the GV invariants. Furthermore we characterize the associated Higgs branches by computing their dimensions and flavor groups. With our techniques we extract more refined data such as the charges of the hypers under the flavor group.
Immune checkpoint inhibition improves antimyeloma activity of bortezomib and STING agonist combination in Vk*MYC preclinical model
Authors: Sokolowska Olga , Rodziewicz-Lurzynska Anna , Pilch Zofia , Kedzierska Hanna , Chlebowska-Tuz Justyna , Sosnowska Anna , Szumera-Cieckiewicz Anna , Sokol Kamil , Barankiewicz Joanna , Salomon-Perzynski Aleksander , Ciepiela Olga , Lech-Maranda Ewa , Golab Jakub , Nowis Dominika 
Published: August 2022

AbstractMultiple myeloma (MM), a hematological malignancy of plasma cells, has remained incurable despite the development of novel therapies that improve patients’ outcome. Recent evidence indicates that the stimulator of interferon genes (STING) pathway may represent a novel target for induction of antitumor immune response in multiple myeloma. Here, we investigated antitumor effects of STING agonist with bortezomib with or without checkpoint inhibitor in the treatment of MM. Methods: STING expression in bone marrow plasma cells of 58 MM patients was examined by immunohistochemical staining. The effectiveness of the proposed therapy was evaluated in vivo in a syngeneic transplantable mouse model of MM (Vĸ*MYC) in immunocompetent mice. Flow cytometry was used to assess tumor burden and investigate activation of immune response against MM. ELISA was performed to measure serum inflammatory cytokines concentrations upon treatment. Results: Combining a STING agonist [2′3′-cGAM(PS)2] with bortezomib significantly decreased tumor burden and improved the survival of treated mice compared to either of the compounds used alone. The combination treatment led to secretion of pro-inflammatory cytokines and increased the percentage of neutrophils, activated dendritic cells and T cells in the tumor microenvironment. However, it resulted also in increased expression of PD-L1 on the surface of the immune cells. Addition of anti-PD1 antibody further potentiated the therapeutic effects. Conclusions: Our findings indicate high antimyeloma efficacy of the three-drug regimen comprising bortezomib, STING agonist, and a checkpoint inhibitor.
The Development of Individual Ambidexterity Across Institutional Environments: Symmetric and Configurational Analyses
Authors: Zhang Jing A. , Bai Tao , Tang Ryan W. , Edgar Fiona , Grover Steven , Chen Guoquan 
Published: August 2022

AbstractBuoyed by recent calls for research to explore micro-level cognitive explanations for ambidexterity, this study examines how individuals’ self-efficacy and resilience affect individual ambidexterity across different institutional environments. Building on social cognitive theory, we posit that self-efficacy enhances ambidexterity via resilience and that such relationship varies across economic institutional environments. Our symmetric (PLS-SEM) and configurational (fsQCA) analyses of 1907 knowledge workers in China, New Zealand and Australia provide supportive and complementary evidence for these theoretical arguments. Specifically, PLS-SEM reveals that the mediating effects of resilience on the relationship between self-efficacy and individual ambidexterity are stronger in an environment where economic institutions are weak. fsQCA complements PLS-SEM by showing that individual ambidexterity can be explained by multiple configurations of psychological self-efficacy, resilience, characteristics related to institutions, and personal demographic factors. Taken together, these findings contribute to the international business literature by providing a nuanced understanding of how different psychological resources integrate and interact with institutional factors to enhance individual ambidexterity.
Characterization of the Microstructure and Thermomechanical Properties of Invar 36 Coatings Deposited by HVOF and Cold Gas Processes
Authors: Tillmann W. , Khalil O. , Baumann I. 
Published: August 2022

AbstractThe effect of impact velocity and temperature of invar particles deposited by high-velocity oxygen fuel (HVOF) and cold spray processes on the microstructure and oxidation content of invar coatings is not fully understood. Additionally, the effect of coating thickness on the coefficient of thermal expansion (CTE) of the coated material and the influence of cold working on the coating hardness are also insufficiently investigated. In the present study, invar coatings were deposited at temperatures close to and below the melting point of invar particles to maintain low CTE. It was found that particle impact temperature and velocity strongly affect pore formation and cohesiveness but slightly affect the hardness of invar coatings. Higher particle impact velocities with impact temperatures close to the invar’s melting point enhance highly the cohesiveness of HVOF-invar coatings. Furthermore, invar coatings stabilize the CTE of the coated material up to a temperature of 227 °C. An increment in the coating’s thickness of 150 µm leads to reducing the CTE of the coated material (Al) in the in-plane direction by 7.65%. Applying cold working using 200 kN compression increases the hardness of the treated coatings by 6% while machine hammer peening (MHP) has a slight effect.
Thyroid Nodules with Indeterminate FNAC According to the Italian Classification System: Prevalence, Rate of Operation, and Impact on Risk of Malignancy. An Updated Systematic Review and Meta-analysis
Authors: Trimboli Pierpaolo , Ferrarazzo Giulia , Cappelli Carlo , Piccardo Arnoldo , Castellana Marco , Barizzi Jessica 
Published: August 2022

AbstractA thyroid nodule classified as indeterminate on fine-needle aspiration cytology (FNAC), hereafter referred to as an indeterminate thyroid nodule (ITN), represents a clinical dilemma. The Italian Consensus for the Classification and Reporting of Thyroid Cytology (ICCRTC) divides ITNs into low- and high-risk categories (i.e., TIR3A and TIR3B, respectively) to better manage patients. This study aimed to achieve high-evidence estimates of the prevalence, rate of operation, and risk of malignancy of ITNs, including TIR3A and TIR3B ITNs. This systematic review was conducted according to MOOSE to retrieve all original studies citing ICCRTC. The last search was performed in February 2022. The risk of bias of the included studies was assessed. Separate proportion meta-analyses were performed with a random-effect model using OpenMeta[Analyst]. The online search processed 271 studies, and 33 were finally considered. First, the cancer prevalence among ITNs was 32.4%. Second, the cancer prevalence among TIR3As was 12.4%, with heterogeneity (I2 90%) explained by a linear correlation between sample size and cancer rate (p = 0.009). Third, the cancer prevalence among TIR3Bs was 44.4%, with heterogeneity (I2 75%) explained by the inverse correlation between sample size and cancer rate (p = 0.031). Fourth, the prevalence of ITNs, TIR3A, and TIR3B among FNACs was 29.6%, 12.6%, and 12.9%, respectively, with sample size and TIR3B prevalence being inversely correlated (p = 0.04). Fifth, the operation rates of ITNs, TIR3A, and TIR3B were 54.3%, 48.3%, and 75.2%, respectively, and the sample size and TIR3A operation rate were inversely correlated (p = 0.010). These data strongly support the division of ITNs into low- and high-risk subcategories. Importantly for clinical practice, the cancer rate among ITNs is significantly influenced by the study sample size.
The EU Succession Certificate
Authors: van Erp Sjef , Zimmermann Katja 
Published: August 2022

AbstractThe European Certificate of Succession is an obligatory form that may be used in cross-border succession cases. The form standardizes the information to be provided to interested parties. Could this standardization be further developed through digitalization, as standardization and digitalization are as closely connected as standardization and the use of forms? Could an e-copy of the certificate, issued by a smart contract running on a blockchain, be stored in the e-wallet which every European citizen might have in the near future, allowing the digital presentation of the copy to, for example, a bank or a land registry, securing Self-Sovereign Identity?
Neuropilin-2 Signaling Modulates Mossy Fiber Sprouting by Regulating Axon Collateral Formation Through CRMP2 in a Rat Model of Epilepsy
Authors: Li Yuxiang , Tong Fangchao , Zhang Yiying , Cai Yiying , Ding Jing , Wang Qiang , Wang Xin 
Published: August 2022

Abstract
Programmed neural circuit formation constitutes the foundation for normal brain functions. Axon guidance cues play crucial roles in neural circuit establishment during development. Whether or how they contribute to maintaining the stability of networks in mature brains is seldom studied. Upon injury, neural rewiring could happen in adulthood, of which mossy fiber sprouting (MFS) is a canonical example. Here, we uncovered a novel role of axon guidance molecule family Sema3F/Npn-2 signaling in MFS and epileptogenesis in a rat model of epilepsy. Dentate gyrus-specific Npn-2 knockdown increased seizure activity in epileptic animals along with increased MFS. Hippocampal culture results suggested that Npn-2 signaling modulates MFS via regulating axon outgrowth and collateral formation. In addition, we discovered that Sema3F/Npn-2 signal through CRMP2 by regulating its phosphorylation in the process of MFS. Our work illustrated that Npn-2 signaling in adult epilepsy animals could potentially modulate seizure activity by controlling MFS. MFS constitutes the structural basis for abnormal electric discharge of neurons and recurrent seizures. Therapies targeting Npn-2 signaling could potentially have disease-modifying anti-epileptogenesis effects in epilepsy treatment.
Clinical translation of gold nanoparticles
Authors: Zhang Rui , Kiessling Fabian , Lammers Twan , Pallares Roger M. 
Published: August 2022

AbstractGold nanoparticles display unique physicochemical features, which can be useful for therapeutic purposes. After two decades of preclinical progress, gold nanoconstructs are slowly but steadily transitioning into clinical trials. Although initially thought to be “magic golden bullets” that could be used to treat a wide range of diseases, current consensus has moved toward a more realistic approach, where gold nanoformulations are being investigated to treat specific disorders. These therapeutic applications are dictated by the pharmacokinetics and biodistribution profiles of gold nanoparticles. Here, we analyze the current clinical landscape of therapeutic gold nanoconstructs, discuss the shared characteristics that allowed for their transition from bench to bedside, and examine existing hurdles that need to be overcome before they can be approved for clinical use.

Graphical Abstract
Long-term ceramic matrix composite for aeroengine
Authors: Song Chaokun , Ye Fang , Cheng Laifei , Liu Yongsheng , Zhang Qing 
Published: August 2022

AbstractThree strategies were proposed to prolong the service life of continuous fiber-reinforced silicon carbide ceramic matrix composite (CMC-SiC), which served as thermal-structure components of aeroengine at thermo-mechanical-oxygenic coupling environment. As for some thermal-structure components with low working stress, improving the degree of densification was crucial to prolong the service life, and the related process approaches were recited. If the thermal-structure components worked under moderate stress, the matrix cracking stress (σmc) should be improved as far as possible. The fiber preform architecture, interface shear strength, residual thermal stress, and matrix strengthening were associated withσmcin this review. Introducing self-healing components was quite significant with the appearance of matrix microcracks when CMC-SiC worked at more severe environment for hundreds of hours. The damage can be sealed by glass phase originating from the reaction between self-healing components and oxygen. The effective self-healing temperature range of different self-healing components was first summarized and distinguished. The structure, composition, and preparation process of CMC-SiC should be systematically designed and optimized to achieve long duration target.
Adaptive Solutions to the Problem of Vulnerability During Sleep
Authors: Wichlinski Lawrence J. 
Published: August 2022

AbstractSleep is a behavioral state whose quantity and quality represent a trade-off between the costs and benefits this state provides versus the costs and benefits of wakefulness. Like many species, we humans are particularly vulnerable during sleep because of our reduced ability to monitor the external environment for nighttime predators and other environmental dangers. A number of variations in sleep characteristics may have evolved over the course of human history to reduce this vulnerability, at both the individual and group level. The goals of this interdisciplinary review paper are (1) to explore a number of biological/instinctual features of sleep that may have adaptive utility in terms of enhancing the detection of external threats, and (2) to consider relatively recent cultural developments that improve vigilance and reduce vulnerability during sleep and the nighttime. This paper will also discuss possible benefits of the proposed adaptations beyond vigilance, as well as the potential costs associated with each of these proposed adaptations. Finally, testable hypotheses will be presented to evaluate the validity of these proposed adaptations.
Big data and machine learning: A roadmap towards smart plants
Authors: Dorneanu Bogdan , Zhang Sushen , Ruan Hang , Heshmat Mohamed , Chen Ruijuan , Vassiliadis Vassilios S. , Arellano-Garcia Harvey 
Published: August 2022

AbstractIndustry 4.0 aims to transform chemical and biochemical processes into intelligent systems via the integration of digital components with the actual physical units involved. This process can be thought of as addition of a central nervous system with a sensing and control monitoring of components and regulating the performance of the individual physical assets (processes, units, etc.) involved. Established technologies central to the digital integrating components are smart sensing, mobile communication, Internet of Things, modelling and simulation, advanced data processing, storage and analysis, advanced process control, artificial intelligence and machine learning, cloud computing, and virtual and augmented reality. An essential element to this transformation is the exploitation of large amounts of historical process data and large volumes of data generated in real-time by smart sensors widely used in industry. Exploitation of the information contained in these data requires the use of advanced machine learning and artificial intelligence technologies integrated with more traditional modelling techniques. The purpose of this paper is twofold: a) to present the state-of-the-art of the aforementioned technologies, and b) to present a strategic plan for their integration toward the goal of an autonomous smart plant capable of self-adaption and self-regulation for short- and long-term production management.
Systematic review on ensuring the global food security and covid-19 pandemic resilient food systems: towards accomplishing sustainable development goals targets
Authors: Kumareswaran Keerththana , Jayasinghe Guttila Yugantha 
Published: August 2022

AbstractCovid-19, one of the most critical and widespread global pandemics, has resulted in extraordinary risk corollaries engulfing millions of people's lives and has caused an unprecedented economic downturn while amplifying food insecurity. A systematic review of 132 scientific communications was performed over a 15-year period, using articles from the ScienceDirect and Web of Science databases (2006–2021). In addition, 24 policy briefs, country papers, and publications from the UN, WHO, FAO, and OECD were cited. The aim of this paper is to provide a comprehensive review of existing literature on the adverse effects of the Covid-19 pandemic on agricultural food systems, as well as potential strategies for building robust, resilient, and sustainable food systems to ensure global food security, safety, and endeavors regarding future global emergencies, as well as new research policies while achieving SDG targets. This would fill a research gap while also having long-term implications for health, agricultural, and food resilience policy development in a rapidly changing world. Covid-19 demonstrates how human, animal, and environmental health are all interconnected, emphasizing the need for one health legislation and a paradigm shift in planetary health. Furthermore, it identifies potential mechanisms for rebuilding better systems by shifting priorities toward policy coherence, innovative food system governance, re-engineering market access, and nexus thinking in the food system approach. According to our findings, the COVID-19 posed unavoidable impediments to achieving SDG targets for food security and household poverty.
Graphical abstract
Effect of natural sources rich in calcium on treated rats induced osteoporosis
Authors: Sawy Hayam A. El , Hassan Doaa F. , Rizk Ayat I. 
Published: August 2022

AbstractThe present study aimed to treat female rats’ osteoporosis using natural sources rich in calcium (permeate with kiwi or fig). Thirty-two female rats weighting 150 ± 10 g were used in this experiment. After adaptation period (7 days), rats were divided to 8 groups (four in each group); first group worked as a control negative and other groups were injected with 1 mg Dex. /kg/bw glucocorticoid (dexamethasone) for 7 days to induce osteoporosis. Second group was considered as a positive group and other groups were treated with beverage (kiwi with permeate or fig with permeate) at different concentrations, i.e., 20, 30 and 40%. The DPPH test was recorded 69.19, 87.01, 68.95, and 44.88% for fresh kiwi, refrigerator kiwi beverage, fresh fig, and refrigerator fig beverage respectively. Meanwhile, using ABTS recorded of 32.6, 39.07, 36.66 and 41.99 Trolox/100 g for above mentioned treatments. In general, total phenol and total flavonoid values of fig treatments were high compared with kiwi treatments. The antimicrobial examination showed an increase in lactic acid bacteria due to refrigeration in both beverages and less total count. Mold, yeast, and coliform not detected. The biological assay resulted in decrease weight gain and feed intake while feed efficiency ratio slightly affected due to beverages. Ca and P content of osteoporotic femur have shown an increase more than the potassium content. Also, serum Ca, P, PTH, Vit. D and protein increased significantly as the result of beverage treatments. The X- ray showed an improved of bone in all treatments compared with (+) control. It could be concluded that permeate mixed with kiwi or fig can be used as a therapeutic diet for subjects, who suffered from osteoporosis.
Global incidence and risk factors of post-operative sore throat among patients who underwent surgery: A systematic review and meta-analysis
Authors: Obsa Mohammed Suleiman , Adem Abdi Oumer , Bancha Bereket , Gelgelu Temesgen Bati , Gemechu Ashebir Debalke , Tilla Mebratu , Nugusse Mitiku Ayele , Wosene Naol Gorde , Gobena Negeso , Hamu Ahmed , Abdulkadir Shemseddin 
Published: August 2022

Abstract

Background
Postoperative sore throat is a common, uncomfortable, stressful sequel of tracheal intubation that contributes to postoperative mortality and morbidity following general anesthesia. Therefore, reducing risks of post-operative sore throat is important to improve patient outcome.

Objectives
The objective of this systematic review and meta-analysis was to evaluate the incidence and risk factors of postoperative sore throat among patients who underwent surgery.

Methods
Studies were retrieved from PubMed, Cochrane Database, Cinahl, Scopus, Mednar, Hinari and Google Scholar by employing a combination of search terms with Boolean operators. Heterogeneity across studies was assessed using the Cochrane Q test. Funnel plot was used for visual assessment of publication bias. Subgroup analyses by country and meta-regression was performed to explore the possible causes of heterogeneity. Egger’s weighted regression test at a p-value < 0.05 was used to assess the presence of publication bias. Sensitivity analysis was performed to judge whether the pooled effect size was influenced by individual study. Stata v14.0 (Statacorp, College Station, Texas, USA) software was used for all statistical analyses. STATA software version 14 was used for all statistical analyses.

Result
A total of 11 studies with 5885 total sample size were included. The total number of patients who developed Post-operative sore throat was 2252. The pooled prevalence of Post-operative sore throat was 40.48% (95% CI: 35.16, 45.79). The visual inspection of the funnel plot showed the symmetrical distribution. Patients who had number of a single attempts were about 42.5% less likely to develop POST than patients who had multiple intubation attempts (OR: 0.58(0.38–0.88), P = 010, I2: 86.6%. Additionally, duration of tube in place less than 1 h was about 18.7% more likely to develop POST than who were not (OR: 1.19(0.29–4.79), P = 0.028, I2: 0.0%). The other independent predictors of POST were OR: 3.01(0.57–15.84), P = 0.19, I2: 92.3%) and OR: 1.56(0.97–2.58), P = 0.080, I2: 0.0%) respectively.

Conclusions
Patients’ age and sex, size of ETT and LMA, duration of ETT in trachea, experience of anesthetists’, number of attempts, induction agent, and smoking were revealed more common causes of sore throat. The number of attempts and the length of tube in place were both linked to the occurrence of postoperative sore throat.

Research Registry
Our unique identifying number is reviewregistry1416.

Highlights