bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparisons on factors affecting residents fulfilling self-determination in ethno-specific and mainstream nursing homes: a qualitative study
Authors: Xiao Lily , Gregoric Carolyn , Gordon Sue , Ullah Shahid , Goodwin-Smith Ian , Muir-Cochrane Eimear , Blunt Sara 
Published: July 2022

Abstract
Background
Studies revealed that supporting residents fulfilling self-determination is positively associated with their health, wellbeing and quality of life. Cross-cultural care poses significant challenges for nursing home residents to fulfil their self-determination in control of own care and maintaining meaningful connections with others. The aim of the study was to compare factors affecting residents fulfilling self-determination in ethno-specific and mainstream nursing homes.
Methods
A qualitative descriptive approach was applied to the study. Culturally competent care and person-centred care were employed as guiding frameworks. Individual interviews or a focus group with residents and family members were conducted to collect data.
Results
In total, 29 participants participated in the study. Three main themes were identified: communicating needs and preferences; mastering own care; and maintaining meaningful relationships. Each theme includes sub-themes that detail similarities and differences of factors affecting residents fulfilling self-determination in the two type nursing homes. Findings indicate that residents from both types of nursing homes experienced challenges to communicate their care needs and preferences in daily care activities. Moreover, residents or their representatives from both types of nursing homes demonstrated motivation and competence to master residents’ care based on their individual preferences, but also perceived that their motivation was not always supported by staff or the nursing home environment. Residents’ competence in mastering their care activities in ethno-specific nursing homes was based on the condition that they were given opportunities to use a language of choice in communication and staff and the nursing home demonstrated culturally competent care for them. In addition, ethno-specific nursing homes showed more recourse to support residents to maintain meaningful relationships with peers and others.
Conclusions
Culturally competent care created by staff, nursing homes and the aged care system is a basic condition for residents from ethnic minority groups to fulfil self-determination. In addition, person-centred care approach enables residents to optimise self-determination.
Molecular characterization of a novel mitovirus from Rhizoctonia solani
AG-4 HG Ⅲ strain XMC-IF
Authors: Sun Aili , Sun Yang , Luo Li , Zhao Lianjing , Li Chengyun , Yang Genhua , Dong Wenhan 
Published: July 2022

Abstract
A double-stranded RNA (dsRNA) segment was isolated from Rhizoctonia solani AG-4 HGIII strain XMC-IF (designated as Rhizoctonia solani mitovirus IF, RsMV-IF). The complete sequence was 2794 bp in length with 57.50% A+U content and contained a large open reading frame (ORF) when the fungal mitochondrial genetic code was used. ORF potentially encoded for a 95.76 kDa protein that contained a conserved domain of an RNA-dependent RNA polymerase (RdRp). BLASTp analysis revealed that the RdRp domain of RsMV-IF had 47.52% to 73.24% sequence identity to sequences of complete genome viruses in the genus Mitovirus and was most similar (73.24% identical) to that of Alternaria alternata mitovirus 1 (AaMV1). Phylogenetic analysis showed that RsMV-IF is a novel member of the genus Mitovirus , family Mitoviridae . This is the first report of the full genome sequence of a mitovirus associated with R. solani AG-4 HGIII.
The use sealing hemostat patch ( HEMOPATCH ®) in laparotomic myomectomy: a prospective case-control study
Authors: Montera Roberto , Ficarola Fernando , Plotti Francesco , Terranova Corrado , Nardone Carlo De Cicco , Guzzo Federica , Angioli Roberto , Luvero Daniela 
Published: July 2022

Abstract
Purpose: Uterine myomas are the most frequent gynecologic disease. In these cases, myomectomy is performed, traditionally laparotomically. However, alternatives have been widely used, including laparoscopic surgery, endoscopic and robotic surgery. During these techniques the diffuse parenchymatous bleeding remains one of the main intra and postoperative complications and sometime requires unplanned hysterectomies. Recently, hemostatic agents and sealants have been used to prevent excessive blood loss during surgical repair.Methods: We propose a prospective case-control study on the use of sealing hemostat patch (HEMOPATCH) on uterine sutures in laparotomic myomectomy. In the period between July 2016 to April 2017, 46 patients suffering from symptomatic uterine fibromatosis underwent surgery. They were divided into 2 groups of 23 patients, with different treatment in the haemostatic phase of oozing bleeding: HEMOPATCH is applied in group A, spray electrocoagulation in group B.Results: In group A, we achieve faster hemostasis (p<0,05), than group B. We report a significantly lower PCR value ​​in the 2nd and 3rd day postoperative for group A compared to group B. Conclusion: HEMOPATCH, during laparotomic myomectomy is a valid alternative solution for obtaining rapid hemostasis and consequently intraoperative and postoperative bleeding. Also, we suggest a lower inflammatory peritoneal state probably correlated to the barrier effect of the patch on the suture.
Lnc-PLA2G4A-4 facilitates the progression of hepatocellular carcinoma by Inducing Versican Expression via sponging miR-23b-3p
Authors: Xiong Jiahui , Lai Yongping , Cheng Niangmei , Wang Fei , Zheng Xiaoyuan , Wang Yingchao , Zhuang Qiuyu , Lin Yantin , Zhao Bixing , Yang Xiao-Yu 
Published: July 2022

Abstract
Aberrant expression of long noncoding RNAs (lncRNAs) has been involved in progression of various human tumors including hepatocellular carcinoma (HCC). However, the role of lncRNAs in HCC has not fully explained. Our study aimed to investigate the biological function and potential molecular mechanism of Lnc-PAL2G4A-4 in HCC. Our study showed that Lnc-PLA2G4A-4 was significantly up-regulated in HCC tissues and higher Lnc-PLA2G4A-4 was remarkably related to tumor size, microvascular invasion and poor prognosis of HCC patients. Functionally, Lnc-PLA2G4A-4 positively regulated cell proliferation, invasion and migration in vitro, and facilitate lung metastasis of HCC in vivo. Mechanistically, Lnc-PLA2G4A-4 functioned as a competing endogenous RNA (ceRNA) to bind to miR-23b-3p and subsequently facilitated miR-23b-3p’s target gene versican (VCAN) expression in HCC cells. Over-expression of miR-23b-3p could reversed cell phenotypes caused by Lnc-PLA2G4A-4 in HCC and suppress the expression of versican by rescue analysis. Collectively, Lnc-PLA2G4A-4 promotes the progression of HCC via targeting miR-23b-3p/versican axis, which might be a potential biomarker and therapeutic target for HCC.
Fragility curves of masonry buildings in aggregate accounting for local mechanisms and site effects
Authors: Angiolilli Michele , Brunelli Andrea , Cattari Serena 
Published: July 2022

Abstract
Masonry buildings in aggregate are largely diffused within the existing Italian and European building stock, especially in historical centres. Their seismic evaluation represents a difficult and open task that has not been exhaustively investigated so far. The study proposes a procedure aimed at evaluating the potential impact of the combination of local mechanisms and site-amplification in terms of fragility curves on an existing masonry aggregate. The latter consists of five adjacent structural units mutually interacting with each other during seismic sequences. The aggregate is inspired by the unreinforced masonry (URM) built heritage of the historic centre of Visso struck by the Central Italy 2016/2017 earthquakes. It was proved to be negatively affected especially by the site-amplification phenomena. The in-plane (IP) response of URM buildings was simulated through nonlinear dynamic analyses performed on a 3D equivalent frame model of the structure, whereas out-of-plane (OOP) mechanisms were analysed by adopting the rigid-block assumption but assuming as seismic input the floor accelerations derived from the post-processing of data derived from the global 3D model. Also an innovative procedure considering the pounding effect to the global response of the building was presented. Two soil conditions were assumed with (freefield) and without (bedrock case) site amplification. In the first case, a site response analysis based on a 1D soil model aimed to reproduce the actual soil profile under the examined aggregate has been carried out. The results showed that site effects strongly affected the seismic vulnerability of the aggregate, also possibly altering the combination between IP and OOP mechanisms with respect to what expected on basis of evidence from other historical centres. More specifically, for bedrock condition, the overall seismic response of the buildings in aggregate was strongly affected by such a combination, especially for medium-high damage levels where local mechanisms were prevailing with respect to the IP response. Conversely, for freefield condition, IP mainly governed the overall behaviour for all the damage levels, consistently with the field evidence. The result appears also affected by the architectural configuration of such buildings, characterized by quite large openings at ground floor.
Metabolomics analysis reveals metabolite changes during freeze-drying and heat drying of Angelica dahuric
Authors: Wu Qinghua , Yan Qi , Jiang Lan , Chen Cuiping , Huang Xulong , Zhu Xinglong , Zhou Tao , Chen Jiang , Yan Jie , Wen Feiyan , Pei Jin 
Published: July 2022

Abstract
Angelica dahurica (Angelica dahurica Fisch. ex Hoffm.) is a traditional Chinese medicine with active ingredients, including coumarins and volatile oil. Drying is closely associated with the qualities of Chinese medicinal materials. An increasing body of evidence suggests that coumarin content is upregulated with increased temperature within a certain range; however, the underlying mechanism remains unclear. This study sought to determine the key differential metabolites and metabolic pathways related to this phenomenon. Liquid Chromatography with tandem mass spectrometry (LC-MS/MS) based targeted metabolomics analysis was performed on Angelica dahurica that were freeze-dried and heat dried. 995 metabolites were detected, and 193 differentially metabolites were identified as key differential metabolites, most of which were upregulated under heat drying. Furthermore, the common metabolic pathways of paired comparison groups were performed based on KEEG annotation and enrichment analysis. It is speculated that the increase of coumarin content is caused by phenylalanine pathway activation under moderate heat treatment. This study revealed the large-scale recombination events of metabolites in Angelica dahurica. First, we identified additional active secondary metabolites apart from coumarins, and volatile oil was significantly accumulated in Angelica dahurica. We further explored the specific metabolite changes and mechanism of the phenomenon of coumarin upregulation caused by temperature rise. These results provide a theoretical reference for future research on the composition and processing method of Angelica dahurica.
Externally Validated AI Model to Identify Prodromal Parkinson’s Disease from ECG
Authors: Akbilgic Oguz , KARABAYIR Ibrahim , Gunturkun Fatma , Goldman Samuel , Kamaleswaran Rishikesan , Davis Robert L , Colletta Kalea , Chinthala Lokesh , Jefferies John L , Bobay Kathleen , Ross George , Petrovitch Helen , Masaki Kamal , Tanner Caroline 
Published: July 2022

Abstract
Autonomic nervous system pathology manifests early in Parkinson’s disease (PD) course. Although heart rate variability measured by a 5-minute electrocardiogram (ECG) is reported to be reduced in PD, little is known about ECG markers during prodromal stage, and brief 10-second ECGs have been rarely studied. The aim of the study is to build externally validated ECG based fully automatic artificial intelligence (AI) model to predict PD risk during prodromal stage. We obtained data for PD and date/age/sex/race-matched control subjects from Loyola University Chicago (LUC) and University of Tennessee-Methodist Le Bonheur Healthcare (MLH). We used AI to predict PD risk from standard 10-second 12-lead ECGs performed between 6-months-5 years before diagnosis. The prediction model was built with MLH data and externally validated with LUC data. We identified 131 cases/1058 controls at MLH and 29 cases/165 controls at LUC. We initially trained models on 90% of the MLH data and internally validated them in the remaining 10%. The best performing model with an internal validation was a convolutional neural network model. External validation with LUC data yielded an AUC of 0.67. When we considered only ECGs obtained 6-months to 1-year preceding PD diagnosis, the external validation AUC was 0.74. Using only ECG, we built a predictive model that correctly classified individuals with prodromal PD with moderate accuracy. The model was effective in an independent cohort, particularly closer to disease diagnosis. Standard ECGs may help to identify individuals with prodromal PD for inclusion in disease-modifying therapeutic trials.
Introduction of STexS Ⅱ: implementing ‘Com probes’ to enhance specificity of high Tm mutant probes
Authors: Kim Jae Jong , Park Hyoung Min , Kyoung A. Young , Lim Si-Kyu , Cha Sun Ho , Lee J. Eugene , Park Byoung Chul 
Published: July 2022

Abstract
The initial introduction of utilizing double helix structural oligonucleotides known as SNP typing with excellent specificity (STexS) in a standard PCR greatly improved detecting single nucleotide polymorphisms (SNP) by enhancing amplification rates of primer-matching strands and interrupting mismatched strands by constant instability of kinetics regarding alignment attaching and detaching. The model was overall beneficial in detecting SNP mutations which were consisting large amounts of wildtype strands such as EGFR mutation genotyping for early detection of non-small cell lung cancer. While the STexS PCR is advantageous in detecting SNPs and biomarkers, limitations were yet observed. Despite the ability of detecting variants 10 times more effective than a typical amplification-refractory mutation system (ARMS) PCR, it could only perform optimally in DNA concentrations around 101~105. To further enhance STexS specificity to perform detecting viral-RNA variants such as the infamous SARS-CoV-2, a novel improvement of the regular TaqMan Probe using Com-probes to inhibit high copy wild targets and amplify low copy mutant targets. By introducing the novel STexS Ⅱ, omicron variants of SARS-CoV-2 was able to be successfully detected in high concentrations of normal genes.
Amino-terminated SiO2-Al2O3 composite aerogels from fly ash for improved removal of Cu2+ and Pb2+ ions in wastewater: one-pot synthesis, excellent adsorption capacity and mechanism
Authors: Yan Furong , Liu Yanxian , Wang Haolei , Zhang Mei , Guo Min 
Published: July 2022

Abstract
In this study, by using a sol-gel grafting-atmospheric drying method, amino-terminated SiO2-Al2O3 composite aerogels, namely 3-aminopropyltriethoxysilane (APTES) or 3-(2-amino-ethoxy) propylmethyldimethoxysilane (AEAPMDS) modified SiO2-Al2O3 aerogels (AMSAAs), were synthesized from the fly ash, and verified as excellent sorbents for removing heavy metal ions (Cu2+ and Pb2+ ions) from wastewater. The effects of modification conditions and testing parameters including pH value, adsorbent dose, initial ions concentration and adsorption time on the micro-structure of AMSAAs and the removal of heavy metal ions were systematically investigated. And the adsorption mechanism was revealed. Results demonstrated that 0.2 mol/L APTES modified aerogels possessed (0.2APTES-SAAs) the best adsorption properties. Under the optimal pH value of 4.0–6.0 and the adsorbent dose of 0.4–0.6 g/L, the equilibrium adsorption capacities of Cu2+ and Pb2+ ions were as high as 195 mg/g and 500 mg/g within 20–30 min, respectively. The adsorption processes were agreed fairly well with Freundlich isotherm adsorption model and the pseudo-second-order kinetic model, which indicated that the adsorption processes were heterogeneous multilayer adsorption and controlled by the chemical reaction between AMSAAs and heavy metal ions.
Prison Health is Community Health: The Indiana Peer Education Program
Authors: Janota Andrea D. , Hibbard Patrick F. , Meadows Meghan E. , Cocco John P. , Carr Abigail L. , Nichols Deborah , Chapman Erika , Maupomé Gerardo , Duwve Joan 
Published: July 2022

Abstract
Background: Concerning health inequities have been found in incarcerated populations, which likely impact broader community health. This paper evaluates the Indiana Peer Education Program (INPEP ECHO), an initiative that aims to improve health knowledge using the Project ECHO (Extension for Community Healthcare Outcomes) model to train people incarcerated in Indiana prisons (USA) as peer health educators inside prisons. Peer educators undergo a 40-hour training and then facilitate 10-hour long health education workshops inside their facilities over several days.Methods: We assessed the changes observed in pre- and post-session survey responses to estimate the impact this program had on peer educators and those they teach via multivariate regression analysis. We also examined peer educator qualitative data for emergent themes and confirmation of survey findings.Results: Findings from the 10-hour workshops showed improved knowledge scores and post-release behavior intentions. Peer educator surveys indicated increases in knowledge, health attitudes, and self-efficacy scores. Qualitative analysis affirms the latter finding and points toward peer educators acquiring expertise in the content they teach and how to teach it and that positive results likely expand beyond participants to others in prison, their families, and the communities to which they return. Further, peer educators shared they felt new purpose and hope tied to their participation in INPEP ECHO. Although these survey results show positive change in the short term, such improvements have been shown in other research to lead to improved middle- and long-term outcomes.Conclusions: Though preliminary, results indicate this type of public health intervention, training incarcerated individuals as peer educators on health topics, appears to increase important health knowledge and behavior intentions, which will likely lead to improvements in personal and public health outcomes. Results also point toward specific improvements associated with peers providing the education, and not external sources. The skills participants attain, as well, seem to increase their sense of purpose and self-efficacy, which have been shown to precede desistance from crime. While more work is necessary, the high costs associated with treating diseases like hepatitis C point toward an urgent need for programs like INPEP.
TTLA: Two-way Trust Between Clients and Fog Servers Using Bayesian Learning Automata
Authors: Bakhtiari Niloofar Barati , Rafighi Masood , Ahsan Reza 
Published: July 2022

Abstract
Fog computing (FC) is a promising paradigm to use as an efficientarchitecture for the Internet of Things applications. Proximity, low latency,flexible resource power, and distributed structure of this architecture are somebenefits of it. A huge number of generated data and their requisites to real-timeprocess causes fog nodes offload number of tasks to the others that make trustissues. Here, each clients prefers to offload task to a trusted server, also eachserver tends to service the trusted clients. This may takes a long especiallywhen we want to consume less energy. In order to encounter this problem,in this paper, we propose a two-way trust management strategy based onBayesian learning automata. The proposed approach outperforms the otherstate-of-the-art approaches in terms of the energy consumption, network usage,latency, response time, and trust value.
The relationship between nutritional status and prognosis in advanced cancer patients in palliative care: a retrospective study
Authors: Mao Ting , Zhao Weiwei , Chen Menglei , Zhang Xiaoju 
Published: July 2022

Abstract
Purpose The study aimed to determine the severe nutritional status, related factors, and its effect on the prognosis of patients with advanced cancer.Methods The study consisted of 208 patients. The nutritional status of the patients was evaluated by the biochemical factors (serum albumin, transferrin and hemoglobin levels), anthropometric parameters (body weight change and BMI), questionnaires (PG-SGA) and physical activity (KPS). Severe nutritional status was diagnosed with the PG-SGA score of ≥9. The factors related to nutritional status were determined using a logistic regression analysis. Kaplan-Meier survival analysis and the log-rank test were used to calculate OS. The effect of poor nutritional status on survival was performed by Cox regression analysis.Results The median age was 64 years (28–89). Severe nutritional status was found in 56.4% of patients according to PG-SGA. The factors associated with severe nutritional status according to PG-SGA were age, BMI＜18.5 kg/m2, KPS < 80, anemia, nutrition impact symptoms (loss of appetite, sleep disturbance, constipation and weight loss), pre-albumin＜200mg/L, albumin＜35g/L, and CRP≥10mg/L. The median overall survival significantly decreased with severe nutritional status according to PG-SGA (p < 0.011), fatigue (p = 0.039), weight loss (p = 0.009) and cancer type (p = 0.026).Conclusion Severe nutritional status is a common factor associated with poor prognosis in advanced cancer patients. Patients should be assessed for nutritional status and supported.
Changes in Smile Parameters Following Surgical-orthodontic Treatment for Skeletal Class III Malocclusion
Authors: Cheng Hsing-Chung , Hsu Ching-Cheng , Moreira Ricardo Aristides Cruz , Chen Li-Sheng 
Published: July 2022

Abstract
PurposeTo analyze differences in smile parameters following surgical-orthodontics in skeletal Class III patients with mandibular prognathism and to identify factors affecting smile parameters after orthognathic surgery.Materials and Methods:These retrospective study comprised of thirty-four patients, diagnosed as having skeletal Class III malocclusion with pure mandible prognathism, were treated with surgical-orthodontics in Taipei Medical University Hospital. Hard and soft tissue variables were measured through lateral cephalometry, and smile esthetics were measured using extraoral photographs. Postoperative changes in smile parameters and differences between sexes were analyzed using the t test. The relationship among smile parameters were analyzed using the Pearson correlation. Random forest methods and decision tree deep learning models were used to identify the variables associated with asymmetry after surgery.Results:Postoperatively, the buccal corridor (p = 0.024), upper lip height (C1) (p = 0.003), and smile index (p = 0.031) were significantly different. The upper midline and right chelion were significantly different between sexes. A very strong positive correlation was observed between the upper lip height and upper lip ratio and between the lower lip height and lower lip ratio; a strong positive correlation was observed between lower teeth exposure and the interlabial gap and between the right chelion and left chelion. By contrast, a strong negative correlation was observed between lower teeth exposure and the smile index and between the smile index and interlabial gap. The following smile parameters associated with asymmetry exhibited the most changes after surgery: lower lip area, interlabial gap, smile index, buccal corridor, and arc ratio.Conclusions:Following orthognathic surgery, marked changes were noted in skeletal, dental, and soft tissue parameters, but smile esthetics changed less from the frontal view. The most changes regarding asymmetry after surgery were noted in the lower lip area, interlabial gap, smile index, buccal corridor, and arc ratio in this order.