bluuebunny/crossref_metadata_2025_split huggingface dataset:
Adjunct Therapy at Time of Examination-Indicated Cervical Cerclage in Singleton Pregnancies: A Systematic Review and Meta-analysis
Authors: Bruno Ann M. , Benson Ashley E. , Metz Torri D. , Blue Nathan R. 
Published: June 2022

Objective Physical examination–indicated cerclage for cervical insufficiency prolongs gestation, but evidence on the addition of adjuncts to further prolong latency is limited. The aim of this systematic review and meta-analysis was to compare gestational latency between those who did and did not receive adjunct antibiotic or tocolytic therapy at the time of examination-indicated cerclage.
Study Design Electronic databases (1966–2020) were searched for randomized controlled trials (RCTs) and cohort studies comparing adjunct antibiotic or tocolytic use versus nonuse at time of examination-indicated cerclage, defined as placement for cervical dilation ≥1 cm, in a current singleton pregnancy. Studies including individuals with intra-amniotic infection, cerclage in place, nonviable gestation, or ruptured membranes were excluded. The primary outcome was latency from cerclage placement to delivery. Secondary outcomes included preterm birth, preterm premature rupture of membranes, birth weight, and neonatal survival. Risk of bias was assessed using standardized tools. Heterogeneity was assessed using χ
2 and I
2 tests. Results were pooled and analyzed using a random-effects model. This study is registered with The International Prospective Register of Systematic Reviews (PROSPERO) with registration no.: CRD42021216370.
Results Of 923 unique records, 163 were reviewed in full. Three met inclusion criteria: one RCT and two retrospective cohorts. The included RCT (n = 50) and one cohort (n = 142) compared outcomes with and without adjunct use of antibiotic and tocolytic, while the second cohort (n = 150) compared outcomes with and without adjunct tocolytic, with a subpopulation also receiving antibiotics. The RCT was nested within one of the cohorts, and therefore only one of these two studies was utilized for any given outcome to eliminate counting individuals twice. Risk of bias was “critical” for one cohort study, “moderate” for the other cohort study, and “some concerns” for the RCT. Gestational latency could not be pooled and meta-analyzed. Adjunct tocolytic-antibiotic therapy was not associated with a decrease in risk of preterm delivery <28 weeks (relative risk [RR] = 0.90, 95% confidence interval [CI]: 0.65–1.26; χ
2 = 0.0, I
2 = 0.0%) or neonatal survival to discharge (RR = 1.11, 95% CI: 0.91–1.35; χ
2 = 0.05, I
2 = 0.0%).
Conclusion There is not enough evidence to robustly evaluate the use of adjunct tocolytics or antibiotics at time of examination-indicated cerclage to prolong latency.
Key Points
Interventional Pulmonology and the Esophagus: Tracheostomy and Percutaneous Endoscopic Gastrostomy Placement
Authors: Magge Anil , Oberg Catherine L. 
Published: June 2022

AbstractTracheostomy is a procedure commonly performed in intensive care units (ICU) for patients who are unable to be weaned from mechanical ventilation. Both percutaneous and surgical techniques have been validated and are chosen based on the local expertise available. A primary advantage to the percutaneous technique is the ability to perform this procedure in the ICU without transporting the patient to a procedure suite or operating room; this has become particularly important with the novel coronavirus disease 2019 (COVID-19) pandemic. An additional advantage is the ability to perform both the tracheostomy and the gastrostomy tube placement, if needed, during the same anesthetic episode. This decreases the need for additional sedation, interruption of anticoagulation, repeat transfusion, and coordination of care between multiple services. In the context of COVID-19, combined tracheostomy and gastrostomy placement exposes less health care providers overall and minimizes transportation needs.
Work stress, health and wellbeing: evidence from the older adults labor market in India
Authors: Malik Manzoor Ahmad , Singh S. P. , Jyoti Jyoti , Pattanaik Falguni 
Published: June 2022

AbstractOlder adults are the most vulnerable group in the labor market, given their physical and functional health risks. Moreover, they are also at a greater risk of psychological factors like work stress due to risk of age, ageism and social well-being. Given these challenges and the growing proportion of older adults in the developing world, this paper studies the theoretical connotation between work stress and health related wellbeing outcomes among working elderly in India. Using BKPAI survey this study adopts multiple modeling approach (descriptive analysis, one-way analysis of variance, and a logit regression model) to test the association between work stress and wellbeing and understand this theoretical connotation in elderly labor market. Our results confirm that work stress is found to be significantly associated with socio-economic and health risks like income, gender, education, morbidity, disability, and socio-psychological barriers among working older adults. Females are likely to have more risk for work stress [OR, 1.72; (95% CI 2.89–2.91)] than males. Similarly, more affluent groups (wealthiest) are less likely to have any work stress [OR, 0.38; (95% CI-0.25–0.58)]. Older adults with multi-morbidity are at greater odds of having work stress [OR 2.26; (95% CI-1.74–2.94)]. Work stress is a common issue that enhances at higher ages due to the work, health, and socio-economic vulnerability of older adults. The study finds a significant impact of these factors on work stress and therefore argues for a comprehensive policy approach to address the psychological health risk of the working older adults in the labor market.
Hepatitis A testing and susceptibility in men who have sex with men: an unintended benefit of PrEP
Authors: Gouda Mahmoud , Fitzpatrick Colin , Williams Deborah , Richardson Daniel 
Published: June 2022

Hepatitis A is a sexually transmitted enteric infection in men who have sex with men (MSM). HIV pre-exposure prophylaxis (PrEP) has increased opportunities for sexual health interventions in MSM. 588 (372 in 2019, 216 in 2021) MSM attended for the first time in the study periods. MSM were significantly more likely to be screened for Hepatitis A susceptibility in 2021 than 2019 (93% vs 56%, P = 0.0001). Susceptibility (Hepatitis A IgG negative) to Hepatitis A did not change between in 2021 and 2019 (48% vs 47%, P = 0.921). De-medicalising PrEP is important as it will increase overall uptake. However, coupling PrEP with other sexual health interventions must not be lost.
Advances in Embodied Construction Grammar*
Authors: Feldman Jerome A. 
Published: June 2022

Abstract
This chapter describes the continuing goals and present status of the ICSI/UC Berkeley efforts on Embodied Construction Grammar (ECG). ECG is semantics-based formalism grounded in cognitive linguistics. ECG is the most explicitly inter-disciplinary of the construction grammars with deep links to computation, neuroscience, and cognitive science. Work continues on core cognitive, computational, and linguistic issues, including aspects of the mind/body problem. Much of the recent emphasis has been on applications and on tools to facilitate new applications. Extensive documentation plus downloadable systems and grammars can be found at the ECG Homepage.1
Implicit landmarks and opposite polarities in French motion predicates
Authors: Aurnague Michel 
Published: June 2022

Abstract
This chapter tackles two important aspects of the association of French motion verbs and spatial PPs. The main notions used in order to characterize strict motion predicates are first recalled. The possibility, for the verbs, of appearing in constructions that do not express the landmark entity of the motion event is studied (implicit landmark constructions), and it is argued to depend on the spatio-temporal structure of the verbs and on various other factors. Then, the association of verbs and PPs with opposite polarities is examined which turns out to be in close correlation with the existence of an “implicit use”. The conclusion emphasizes the asymmetries/dissymmetries between initial and final motion events revealed by the constructions studied.
Higher-order generalized uncertainty principle applied to gravitational baryogenesis
Authors: Feng Zhong-Wen , Zhou Xia , Zhou Shi-Qi 
Published: June 2022

Abstract
The gravitational baryogenesis plays an important role in the study of baryon asymmetry. However, the original mechanism of gravitational baryogenesis in the radiation-dominated era leads to the asymmetry factor η equal to zero, which indicates this mechanism may not generate a sufficient baryon asymmetry in the early Universe. In this paper, we investigate the gravitational baryogenesis for the generation of baryon asymmetry in the early Universe by using a new higher-order generalized uncertainty principle (GUP). It is demonstrated that the entropy and the Friedman equation of the Universe deviate from the original cases due to the effect of the higher-order GUP. Those modifications break the thermal equilibrium of the Universe, and in turn produce a non-zero asymmetry factor η. In particular, our results satisfy all of Sakharov's conditions, which indicates that the scheme of explaining baryon asymmetry in the framework of higher-order GUP is feasible. In addition,
combining our theoretical results with the observational data, we constraint the GUP parameter β
0, whose bound is between 8.4 × 1010 ∼ 1.1 × 1013.
p

T
dispersion of inclusive jets in high-energy nuclear collisions*
Authors: Chen Shi-Yong , Yan Jun , Dai Wei , Zhang Ben-Wei , Wang En-Ke 
Published: June 2022

Abstract
In this study, we investigate the impact of jet quenching on the

dispersion (

) of inclusive jets (

) in central Pb+Pb (0%–10%) collisions at

TeV. The partonic spectrum in the initial hard scattering of elementary collisions is obtained by an event generator POWHEG+PYTHIA, which matches the next-to-leading order (NLO) matrix elements with parton showering, and the energy loss of a fast parton traversing through hot/dense QCD medium is calculated using Monte Carlo simulation within the Higher-Twist formalism of jet quenching in heavy-ion collisions. We present model calculations of the normalized

distributions of inclusive jets in p+p and central Pb+Pb collisions at

TeV, which offer good descriptions of ALICE measurements. It is shown that the

distributions of inclusive jets in central Pb+Pb collisions shift significantly to a higher

region relative to those in p+p collisions. Thus, the nuclear modification ratio of the

distributions of inclusive jets is smaller than unity in the small

region and larger than one in the large

region. This behavior is caused by a more uneven

distribution for jet constituents as well as the fraction alteration of quark/gluon initiated jets in heavy-ion collisions. The difference in

distribution between groomed and ungroomed jets in Pb+Pb collisions is also discussed.
Influence of device non-uniformities on the accuracy of Coulomb blockade thermometry
Authors: Pekola Jukka P , Praks Eemil , Yurttagül Nikolai , Karimi Bayan 
Published: June 2022

AbstractWe investigate temperature uncertainty of Coulomb blockade thermometer (CBT) arising from inevitable non-uniformities in tunnel junction arrays. The corrections are proportional to the junction resistance variance in the linear operation regime and this result holds approximately also beyond this originally studied high temperature range. We present both analytical and numerical results, and discuss briefly their implications on achievable uniformity based on state-of-the-art fabrication of sensors.
Soft X-ray radiography for measurements of a dense metal plasma created by intense relativistic electron beam on a tantalum target
Authors: Kurkuchekov V.V. , Atlukhanov M.G. , Burdakov A.V. , Danilov V.V. , Popov S.S. , Skovorodin D.I. , Trunev Yu.A. , Kholopov M.A. , Popov A.S. , Lemzyakov A.G. , Petrozhitskiy A.V. , Rousskikh A.G. , Artyomov A.P. , Fedyunin A.V. , Zhigalin A.S , Erfort A.A. , Kolesnikov P.A. , Politov V.Yu. , Nikitin O.A. , Akhmetov A.R. 
Published: June 2022

Abstract
A radiographic diagnostic has been developed to quantify the
plume of erosion products after the interaction between a target and
a relativistic electron beam. The diagnostic is based on a point
Z-pinch (PZ-pinch) with a metallic plasma jet. It creates an X-ray
source with a typical size of 10 μm, a photon energy of up to
3 keV and a flash duration of 3 ns. The X-ray visualization system
is based on a thin scintillator and a CCD camera. The spatial
resolution of the diagnostic was evaluated experimentally. The
spatial frequency limit was found to be about 1.5 line pairs per
millimeter.

The diagnostic was tested in an experiment performed using an LIA-5
linear induction accelerator. An electron beam with a current of
400 A, an energy of 3.5 MeV and a pulse duration of 80 ns was
focused on a plane tantalum target 1 mm in thickness. The FWHM of
the focal spot was ∼ 2 mm. Radiographs of the plume were taken
with different delays after different accelerator pulses. According
to our data, the plume most commonly propagates toward the
beam. After 70 μs its length was about 70 mm, i.e. the
plume expansion rate was about 1 km/s. The area density of the
semi-transparent regions of the plume was estimated as lying in the
range 3 · 10-16–2 · 1017 cm-2.
Nanometer-sensitive wideband opto-mechanical switching concept
Authors: Herle Dorian , Renaud Philippe , Parriaux Olivier 
Published: June 2022

Abstract
The present paper is concerned with the mechanically extremely sensitive reflection switching concept of a free-space wave impinging on an array of dielectric or semiconductor pillars. Splitting the pillars of a 2D periodic array in its resonant reflection regime at a prescribed wavelength into two parts with a low-index gap of a few nanometers between parts cancels the reflection of a plane wave under normal incidence. The underlying principle lies in the strong and abrupt discontinuity of the electric field component parallel to the pillar axes caused by the gap. The electromagnetic field distribution is consequently deeply perturbed and no longer corresponds to that of an optical resonance of the array; this suppresses the reflection. The electromagnetic analysis of a silicon pillar array leads to the design of a gapless experimental model fabricated by microsystem technologies that exhibits a broad reflection maximum of a few tens of nm at a prescribed wavelength in the visible and near-IR range, and of a pillar structure with nanometer-thick low-index gap exhibiting no reflection peak over this wide wavelength range. A transmission ratio of 1:30 at a 1080 nm peak wavelength between a gapless and a 1.5 index, 30 nm-thick gap structures was measured.
AbLang: an antibody language model for completing antibody sequences
Authors: Olsen Tobias H , Moal Iain H , Deane Charlotte M 
Published: June 2022

AbstractMotivationGeneral protein language models have been shown to summarize the semantics of protein sequences into representations that are useful for state-of-the-art predictive methods. However, for antibody specific problems, such as restoring residues lost due to sequencing errors, a model trained solely on antibodies may be more powerful. Antibodies are one of the few protein types where the volume of sequence data needed for such language models is available, e.g. in the Observed Antibody Space (OAS) database.ResultsHere, we introduce AbLang, a language model trained on the antibody sequences in the OAS database. We demonstrate the power of AbLang by using it to restore missing residues in antibody sequence data, a key issue with B-cell receptor repertoire sequencing, e.g. over 40% of OAS sequences are missing the first 15 amino acids. AbLang restores the missing residues of antibody sequences better than using IMGT germlines or the general protein language model ESM-1b. Further, AbLang does not require knowledge of the germline of the antibody and is seven times faster than ESM-1b.Availability and implementationAbLang is a python package available at https://github.com/oxpig/AbLang.Supplementary informationSupplementary data are available at Bioinformatics Advances online.
NetRAX: accurate and fast maximum likelihood phylogenetic network inference
Authors: Lutteropp Sarah , Scornavacca Céline , Kozlov Alexey M , Morel Benoit , Stamatakis Alexandros 
Published: June 2022

AbstractMotivationPhylogenetic networks can represent non-treelike evolutionary scenarios. Current, actively developed approaches for phylogenetic network inference jointly account for non-treelike evolution and incomplete lineage sorting (ILS). Unfortunately, this induces a very high computational complexity and current tools can only analyze small datasets.ResultsWe present NetRAX, a tool for maximum likelihood (ML) inference of phylogenetic networks in the absence of ILS. Our tool leverages state-of-the-art methods for efficiently computing the phylogenetic likelihood function on trees, and extends them to phylogenetic networks via the notion of ‘displayed trees’. NetRAX can infer ML phylogenetic networks from partitioned multiple sequence alignments and returns the inferred networks in Extended Newick format. On simulated data, our results show a very low relative difference in Bayesian Information Criterion (BIC) score and a near-zero unrooted softwired cluster distance to the true, simulated networks. With NetRAX, a network inference on a partitioned alignment with 8000 sites, 30 taxa and 3 reticulations completes within a few minutes on a standard laptop.Availability and implementationOur implementation is available under the GNU General Public License v3.0 at https://github.com/lutteropp/NetRAX.Supplementary informationSupplementary data are available at Bioinformatics online.
Flow-mediated dilation reference values for evaluation of endothelial function and cardiovascular health
Authors: Heiss Christian , Rodriguez-Mateos Ana , Bapir Mariam , Skene Simon S , Sies Helmut , Kelm Malte 
Published: June 2022

AbstractAimsEndothelial function is essential for cardiovascular health, and flow-mediated dilation (FMD) is an established technique to measure it. This paper aims to assess FMD values in apparently healthy individuals and provides reference values to facilitate wider clinical use.Methods and resultsIn 1,579 apparently healthy individuals (aged 18–76), fasted FMD values (data from 44 studies, 6 institutions, 22 operators) were normally distributed and inversely univariately correlated with age, body mass index, glucose, cholesterol, blood pressure, and brachial artery (BA) diameter. Significant multivariate predictors of FMD were age (−0.4%/decade), BMI (0.04%/kg/m2), smoking (−0.7%), and BA diameter (−0.44%/mm) that together explained 19% of the variability independent of operator, institution or ultrasound machine. Individuals in the high FMD tertile (&gt;6.8%) were younger, had smaller BA diameter, lower blood pressure and cholesterol. In individuals with low- and intermediate fatal cardiovascular risk (SCORE), 26% and 53% of individuals, respectively, had FMD values in the low tertile (&lt;5.4%). After adding data from 385 patients with stable coronary artery disease (CAD), ROC analysis (c = 0.841, P &lt; 0.001) showed that FMD of &gt;6.5% excluded CAD (95% sensitivity; 60% specificity) and FMD &lt;3.1% excluded 95% healthy individuals (95% specificity, 31% sensitivity). A meta-analysis and meta-regression of 82 clinical trials (11 countries, n = 3,509) using similar FMD methodology showed that despite considerable heterogeneity (I2 = 0.97) FMD in healthy individuals was on average 6.4% (95%CI: 6.2%, 6.7%) with no significant differences between countries but a significant age-dependent decline (−0.3%/decade, R2 = 0.13).ConclusionsWe provide an age-adapted frame of FMD reference intervals in apparently healthy individuals for use as a biomarker of cardiovascular health. As the degree of vascular endothelial function integrates environmental and genetic factors with classical CV risk factors, FMD may more comprehensively classify individuals with and without standard modifiable cardiovascular risk factors and serve as a target for cardiovascular prevention.
Methylation of the Hippo effector YAP by the methyltransferase SETD7 drives myocardial ischaemic injury: a translational study
Authors: Ambrosini Samuele , Montecucco Fabrizio , Kolijn Detmar , Pedicino Daniela , Akhmedov Alexander , Mohammed Shafeeq A , Herwig Melissa , Gorica Era , Szabó Petra L , Weber Lukas , Russo Giulio , Vinci Ramona , Matter Christian M , Liuzzo Giovanna , Brown Peter J , Rossi Fabio M V , Camici Giovanni G , Sciarretta Sebastiano , Beltrami Antonio P , Crea Filippo , Podesser Bruno , Lüscher Thomas F , Kiss Attila , Ruschitzka Frank , Hamdani Nazha , Costantino Sarah , Paneni Francesco 
Published: June 2022

Abstract

Aims
Methylation of non-histone proteins is emerging as a central regulatory mechanism in health and disease. The methyltransferase SETD7 has shown to methylate and alter the function of a variety of proteins in vitro; however, its function in the heart is poorly understood. The present study investigates the role of SETD7 in myocardial ischaemic injury.

Methods and results
Experiments were performed in neonatal rat ventricular myocytes (NRVMs), SETD7 knockout mice (SETD7−/−) undergoing myocardial ischaemia/reperfusion (I/R) injury, left ventricular (LV) myocardial samples from patients with ischaemic cardiomyopathy (ICM), and peripheral blood mononuclear cells (PBMCs) from patients with ST-elevation MI (STEMI). We show that SETD7 is activated upon energy deprivation in cultured NRVMs and methylates the Hippo pathway effector YAP, leading to its cytosolic retention and impaired transcription of antioxidant genes manganese superoxide dismutase (MnSOD) and catalase (CAT). Such impairment of antioxidant defence was associated with mitochondrial reactive oxygen species (mtROS), organelle swelling, and apoptosis. Selective pharmacological inhibition of SETD7 by (R)-PFI-2 restored YAP nuclear localization, thus preventing mtROS, mitochondrial damage, and apoptosis in NRVMs. In mice, genetic deletion of SETD7 attenuated myocardial I/R injury, mtROS, and LV dysfunction by restoring YAP-dependent transcription of MnSOD and CAT. Moreover, in cardiomyocytes isolated from I/R mice and ICM patients, (R)-PFI-2 prevented mtROS accumulation, while improving Ca2+-activated tension. Finally, SETD7 was up-regulated in PBMCs from STEMI patients and negatively correlated with MnSOD and CAT.

Conclusion
We show a methylation-dependent checkpoint regulating oxidative stress during myocardial ischaemia. SETD7 inhibition may represent a valid therapeutic strategy in this setting.