bluuebunny/crossref_metadata_2025_split huggingface dataset:
AIMP1 promotes multiple myeloma malignancy through interacting with ANP32A to mediate histone H3 acetylation
Authors: Wei Rongfang , Zhu Yan , Zhang Yuanjiao , Zhao Wene , Yu Xichao , Wang Ling , Gu Chunyan , Gu Xiaosong , Yang Ye 
Published: August 2022

AbstractBackgroundMultiple myeloma (MM) is the second most common hematological malignancy. An overwhelming majority of patients with MM progress to serious osteolytic bone disease. Aminoacyl‐tRNA synthetase‐interacting multifunctional protein 1 (AIMP1) participates in several steps during cancer development and osteoclast differentiation. This study aimed to explore its role in MM.MethodsThe gene expression profiling cohorts of MM were applied to determine the expression of AIMP1 and its association with MM patient prognosis. Enzyme‐linked immunosorbent assay, immunohistochemistry, and Western blotting were used to detect AIMP1 expression. Protein chip analysis, RNA‐sequencing, and chromatin immunoprecipitation and next‐generation sequencing were employed to screen the interacting proteins and key downstream targets of AIMP1. The impact of AIMP1 on cellular proliferation was determined using 3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5‐diphenyltetrazolium bromide (MTT) assay in vitro and a xenograft model in vivo. Bone lesions were evaluated using tartrate‐resistant acid phosphatase staining in vitro. A NOD/SCID‐TIBIA mouse model was used to evaluate the effect of siAIMP1‐loaded exosomes on bone lesion formation in vivo.ResultsAIMP1 expression was increased in MM patients and strongly associated with unfavorable outcomes. Increased AIMP1 expression promoted MM cell proliferation in vitro and in vivo via activation of the mitogen‐activated protein kinase (MAPK) signaling pathway. Protein chip assays and subsequent experiments revealed that AIMP1 interacted with acidic leucine‐rich nuclear phosphoprotein 32 family member A (ANP32A) to regulate histone H3 acetylation. In addition, AIMP1 increased histone H3 acetylation enrichment function of GRB2‐associated and regulator of MAPK protein 2 (GAREM2) to increase the phosphorylation of extracellular‐regulated kinase 1/2 (p‐ERK1/2). Furthermore, AIMP1 promoted osteoclast differentiation by activating nuclear factor of activated T cells c1 (NFATc1) in vitro. In contrast, exosome‐coated small interfering RNA of AIMP1 effectively suppressed MM progression and osteoclast differentiation in vitro and in vivo.ConclusionsOur data demonstrate that AIMP1 is a novel regulator of histone H3 acetylation interacting with ANP32A in MM, which accelerates MM malignancy via activation of the MAPK signaling pathway.
Hantzsch‐Like Synthesis, DNA Photocleavage, DNA/BSA Binding, and Molecular Docking Studies of Bis(sulfanediyl)bis(tetrahydro‐5‐deazaflavin) Analogs Linked to Naphthalene Core
Authors: Ragheb Mohamed A. , Abdelwahab Reham E. , Darweesh Ahmed F. , Soliman Marwa H. , Elwahy Ahmed H. M. , Abdelhamid Ismail A. 
Published: September 2022

AbstractThe cyclocondensation reaction of aldehydes with dimedone and bis(6‐aminopyrimidin‐4‐one) in acetic acid led to the formation of the corresponding bis(pyrimido[4,5‐b]quinoline‐4,6‐diones) which are known as bis(sulfanediyl)bis(tetrahydro‐5‐deazaflavin) analogs in a single step. Also, bis(pyrimido[4,5‐b]quinoline‐4,6‐diones) which are linked to naphthyl core via phenoxymethyl linkage is prepared. The interactions of the synthesized compounds with DNA and bovine serum albumin (BSA) were studied. Gel electrophoresis assay was used to show the capability of the compounds to photocleave the supercoiled pBR322 plasmid DNA in UV‐A (365 nm). Besides, the most photocleavable compound, bis(tetrahydropyrimido[4,5‐b]quinoline‐4,6‐dione) linked to pyridin‐3‐yl at position‐5 exhibits good binding affinities toward CT‐DNA and BSA as supported by UV/VIS spectral studies. In addition to the experimental findings, a molecular docking simulation was performed to collect detailed binding data for this compound to both biomolecules.
A Biochemical Approach for Hedysarum candidissimum from Turkey: Screening Phytochemicals, Evaluation of Biological Activites, and Molecular Docking Study
Authors: Altay Ahmet , Yeniceri Esma , Taslimi Parham , Taskin‐Tok Tugba , Yilmaz Mustafa Abdullah , Koksal Ekrem 
Published: September 2022

AbstractThis study was designed to screen the phytochemical composition and investigate the biological activities of Hedysarum candidissimum extracts and also support the results with molecular docking studies. LC/MS/MS analysis revealed the presence of 22 phytochemical constituents (mainly phenolic acids, flavonoids, and flavonoid glycosides) in the plant structure. The methanol extract exhibited the strongest antioxidant activity among all the extracts with its strong DPPH radical scavenging and iron reducing capacity, as well as high phenolic and flavonoid contents. Additionally, it was found to be the most promising acetylcholinesterase (AChE: IC50: 93.26 μg/mL) and α‐glycosidase (AG: IC50: 28.57 μg/mL) inhibitory activities, supported by the major phenolics of the species through in silico studies. Ethyl acetate extract had the strongest cytotoxic effect on HT‐29 (IC50: 63.03 μg/mL) and MDA‐MB‐453 (IC50: 95.36 μg/mL) cancer cell lines. Both extracts exhibited considerable apoptotic and anti‐migrative effects on HT‐29 cells. The investigations provide phyto‐analytical and bio‐pharmacological results which can be extended by in vivo studies in the future.
Thermal Buckling of Railways
Authors: Piloto Paulo A. G. , Frigeri Ary V. N. , Minhoto Manuel 
Published: August 2022

AbstractThis manuscript presents the results of numerical research regarding the thermal buckling on railway tracks. High temperatures may cause thermal buckling on the railways and due to this fact speed restrictions are often issued to reduce the probability of derailments. Railways are subject to thermal and mechanical loads in which, given some circumstances, buckling may take place. Continuous welded rail (CWR) is more prone to this effect than jointed rails since the longitudinal displacement is restrained. This research is focused on the effect of the track gauge, rail profile, initial imperfection amplitude, sleeper's elasticity modulus, torsional resistance of fastenings, and ballast resistance on the thermal buckling of railways. A total of 144 simulations were developed, concluding that the imperfection level and ballast resistance are the most affecting parameters on the buckling temperature.
On the Applicability of Conventional Seismic Design Methodologies to Hybrid RC‐Steel Systems
Authors: Moreira Rodrigo Falcão , Castro José Miguel , Varum Humberto 
Published: August 2022

AbstractThis paper analyses the adequacy of the q‐factor approach when applied to hybrid RC‐steel systems. This approach is prescribed by EC8‐1 as the basic design method, and usually referred to as the most conservative. However, due to its simplicity and popularity for the design of new structures, practitioners are more likely to resort to it, than to the more complex nonlinear static and dynamic procedures, when dealing with the seismic assessment and strengthening of existing RC buildings. A case‐study application is thus presented to analyse and discuss the difficulties a practitioner will face when assessing the efficiency of a steel‐brace retrofitting system designed within the framework of EC8‐1.
Dendritic cells generated from induced pluripotent stem cells and by direct reprogramming of somatic cells
Authors: Flosdorf Niclas , Zenke Martin 
Published: September 2022

AbstractNovel and exciting avenues allow generating dendritic cells (DC) by reprogramming of somatic cells. DC are obtained from induced pluripotent stem cells (iPS cells), referred to as ipDC, and by direct reprogramming of cells toward DC, referred to as induced DC (iDC). iPS cells represent pluripotent stem cells generated by reprogramming of somatic cells and can differentiate into all cell types of the body, including DC. This makes iPS cells and ipDC derived thereof useful for studying various DC subsets, acquiring high cell numbers for research and clinical use, or applying genome editing to generate DC with wanted properties. Thereby, ipDC overcome limitations in specific DC subsets, which are only found in low abundance in blood or lymphoid organs. iDC are generated by direct reprogramming of somatic cells with a specific set of transcription factors and offer an avenue to obtain DC without a pluripotent cell intermediate. ipDC and iDC retain patient and disease‐specific mutations and this opens new perspectives for studying DC in disease. This review summarizes the current techniques used to generate ipDC and iDC, and the types and functionality of the DC generated.
Diammonium‐inducedDion‐Jacobson 2D/3Dwide‐bandgap perovskite solar cells with enhanced efficiency and stability
Authors: Yu Yue , Liu Rui , Xu Maoxia , Yu Hua 
Published: August 2022

AbstractSurface passivation by two‐dimensional (2D) organic spacers provides promising avenue to substantially enhance the photovoltaic performance and structural stability of perovskite solar cells (PSCs). Herein, a diammonium organic salt of 2,2′‐(Ethylenedioxy) diethyl ammonium diiodide (EDBEI2) is used to passivate surface defects with spontaneously established Dion‐Jacobson (DJ)‐type two‐dimensional/three‐dimensional (2D/3D) perovskite structure. The 2D DJ perovskite (EDBEPbI4) is formed on the surface of 3D WBG film, which passivates surface defects and reduces non‐radiation recombination with better‐matched energy‐level alignment. Consequently, the modified device shows an excellent power conversion efficiency of 18.85% with large open‐circuit voltage of 1.28 V. Besides, such 2D/3D perovskite exhibits better stability, which maintains 89% of its original efficiency after 1000 h under a relative humidity of 30% for the unencapsulated EDBEI2‐treated device. These results give a suggestive strategy to enhance the efficiency and stability of WBG PSCs, potentially, providing a feasible way for achieving the commercialization of perovskites.image
Identification of volatile compounds contributing to pennycress aroma
Authors: Luo Peishan , Reineccius Gary 
Published: September 2022

AbstractThe volatile compounds inherent to wild‐type pennycress seeds were determined using solvent‐assisted flavour extraction (SAFE), combined with gas chromatography‐olfactometry (GC‐O) and aroma extraction dilution analysis (AEDA). In this research, twenty‐nine aroma‐active compounds were detected via GC‐O. With the aid of gas chromatography–mass spectrometry (GC‐MS), retention indices, aroma descriptors and standard chemical verification, ten volatile compounds were positively identified: 2,5−/2,6‐dimethyl‐3‐methoxypyrazine (grassy), allyl isothiocyanate (mustard, horseradish, onion), hexanal (green), (E)‐2‐octenal (earthy), acetic acid (sour), (E)‐2‐nonenal (woody), 1‐octanol (grassy), 1‐nonanol (green), 2‐methylbutanoic acid/3‐methylbutanoic acid (cheesy) and phenethyl alcohol (rose‐like). By matching odour descriptions, mass spectra and retention indices, seven additional volatile compounds were tentatively identified: 1‐pentanol, octanal, (E)‐2‐penten‐1‐ol, (E)‐2‐heptenal, (Z)‐3‐hexen‐1‐ol, (E, E)‐3,5‐octadien‐2‐one and pentanoic acid. These results provide an aroma analysis of pennycress, which can be useful in providing direction for pennycress breeding programs or tailored processing steps to eliminate the undesirable aroma components limiting the use as a food ingredient.
Tuberculosis in a weak health system, conflict and fragile zone: The monetary value of human lives lost associated with deaths of persons older than 14 years in Somalia
Authors: Da'ar Omar B. , Gele Abdi A. 
Published: August 2022

AbstractBackgroundLow tuberculosis (TB) detection and conflict and fragility have overburdened Somalia. This study estimated economic loss associated with TB deaths among persons aged >14 years.MethodUsing epidemiologic and economic data, we calculated the cost based on the framework of the World Health Organization guide of identifying the economic consequences of disease and injury. Baseline loss is the product of years of life lost, non‐health expenditure, and number of deaths. Adjusting for conflict and fragility conditions and growth of non‐health expenditure, we discounted the loss at 3% rate. We conducted a sensitivity analysis of epidemiologic and economic factors.ResultsIn 2017 values, the 9180 reported deaths result in a loss of US$ 44.77 million, a US$ 4877 per death over the discounted years. Conflict conditions would increase the loss by 5.3%, while simultaneous adjustment for conflict and attunement to growth of non‐health expenditure would increase the burden by 54% to US$ 67.28 million. Male fatalities account for 59% of the burden. The baseline result is robust to input variations, although sensitivity analysis suggests conflict and fragility conditions account for greater uncertainty of the loss.ConclusionStakeholders in the healthcare system should minimise the sizeable economic loss by taking measures to enhance surveillance of TB and security.
A novel peroral digital cholangioscope with a large accessory channel: An experimental study
Authors: Tonozuka Ryosuke , Itoi Takao , Nagai Kazumasa , Sofuni Atsushi , Tsuchiya Takayoshi , Ishii Kentaro , Tanaka Reina , Mukai Shuntaro , Minami Hirohito , Yamamoto Kenjiro 
Published: August 2022

AbstractBackground/PurposeA peroral cholangioscope (POCS) can allow direct visualization of the biliary mucosa and its use is becoming more widespread due to improvements in functionality, image quality, and operability, as well as the development of related devices. Recently, a novel mother‐baby peroral cholangioscope (nMB‐POCS) with a large (2‐mm) accessory channel has been developed. In this study, we evaluated the feasibility of this novel POCS in a dry simulation and animal model.MethodsWe evaluated the ease of insertion and maneuverability of the nMB‐POCS, the image quality, and the passage of the devices into the accessory channel and into the common bile duct in a dry and live porcine model.ResultsIn both models, the nMB‐POCS could be easily inserted into the duodenoscope and into the distal bile duct and hilum. The image quality was good, and it was possible to observe the surface structure and the vascular network of the bile duct mucosa in detail.ConclusionsThe nMB‐POCS with its larger accessory channel is expected to improve the efficiency of diagnosis and treatment, and reduce the procedure time. Clinical studies in patients are warranted.
アセチレンと酸素の混合ガスの小爆発により単独気管損傷を生じた稀な1例(A rare case of single tracheal injury caused by a small explosion of a mixed gas of acetylene and oxygen)
Authors: 真道 諸岡 , 雄太 諸江 , 宗博 林 , 彰吾 鷺坂 , 証 乃美 , 卓也 深田 , 智幸 山下 
Published: September 2022

要旨症例は30歳代の男性。溶接作業中にガス漏れを感じ，臭いを嗅いで漏洩部位を探し始めた際に小爆発を起こし受傷した。呼吸困難の後に血痰が出現したため，徒歩で当院救急外来を受診した。来院時，前頸部に皮下気腫を触知し，胸部CTと気管支鏡検査で気管膜様部に約3cmの裂創を認めた。同日開胸手術を行い，気管膜様部を縫合し肋間筋皮弁で被覆した。術後経過は良好で第14病日に徒歩退院した。混合ガスの爆発による胸部気管単独損傷は稀で，本症例も気道熱傷や肺損傷はなく，小爆発による一次爆傷と考えられた。
Diffusion‐Weighted Magnetic Resonance Imaging and Morphological Characteristics Evaluation for Outcome Prediction of Primary Debulking Surgery for Advanced High‐Grade Serous Ovarian Carcinoma
Authors: Li Haiming , Lu Jing , Deng Lin , Guo Qinhao , Lin Zijing , Zhao Shuhui , Ge Huijuan , Qiang Jinwei , Gu Yajia , Liu Zaiyi 
Published: August 2022

BackgroundPreoperative assessment of whether a successful primary debulking surgery (PDS) can be performed in patients with advanced high‐grade serous ovarian carcinoma (HGSOC) remains a challenge. A reliable model to precisely predict resectability is highly demanded.PurposeTo investigate the value of diffusion‐weighted MRI (DW‐MRI) combined with morphological characteristics to predict the PDS outcome in advanced HGSOC patients.Study TypeProspective.SubjectsA total of 95 consecutive patients with histopathologically confirmed advanced HGSOC (ranged from 39 to 77 years).Fields Strength/SequenceA 3.0 T, readout‐segmented echo‐planar DWI.AssessmentThe MRI morphological characteristics of the primary ovarian tumor, a peritoneal carcinomatosis index (PCI) derived from DWI (DWI‐PCI) and histogram analysis of the primary ovarian tumor and the largest peritoneal carcinomatosis were assessed by three radiologists. Three different models were developed to predict the resectability, including a clinicoradiologic model combing MRI morphological characteristic with ascites and CA125 level; DWI‐PCI alone; and a fusion model combining the clinical‐morphological information and DWI‐PCI.Statistical TestsMultivariate logistic regression analyses, receiver operating characteristic (ROC) curve, net reclassification index (NRI) and integrated discrimination improvement (IDI) were used. A P < 0.05 was considered to be statistically significant.ResultsSixty‐seven cases appeared as a definite mass, whereas 28 cases as an infiltrative mass. The morphological characteristics and DWI‐PCI were independent factors for predicting the resectability, with an AUC of 0.724 and 0.824, respectively. The multivariable predictive model consisted of morphological characteristics, CA‐125, and the amount of ascites, with an incremental AUC of 0.818. Combining the application of a clinicoradiologic model and DWI‐PCI showed significantly higher AUC of 0.863 than the ones of each of them implemented alone, with a positive NRI and IDI.Data ConclusionsThe combination of two clinical factors, MRI morphological characteristics and DWI‐PCI provide a reliable and valuable paradigm for the noninvasive prediction of the outcome of PDS.Evidence Level2Technical EfficacyStage 2
Channel transparency and omnichannel retailing: The impact of sharing retail store product availability information
Authors: Ren Xinyi , Windle Robert J. , Evers Philip T. 
Published: September 2022

AbstractAs more firms look to implement omnichannel strategies to mitigate the inherent information barriers between online and offline channels, understanding the outcomes of these initiatives is critical. This study empirically examines the impact of the decision to share brick‐and‐mortar (B&M) store product availability information with customers, specifically focusing on the scenario where a discrepancy exists in the product assortment of online and offline channels. We investigate the impact of this information sharing strategy on customer research shopping trajectories using a proprietary dataset collected from a leading North American retailer. Using a difference‐in‐differences approach, we find that this strategy helps boost the overall sales from customers who reside within the trade area of a retail store. At the channel level, the policy induces customers to migrate from the B&M channel to the online channel after learning that the product selection offered at their local retail store may not meet their needs, resulting in a significant increase in online sales, but a slight decrease in B&M sales. From an operational perspective, our empirical evidence suggests that sharing retail store product availability information leads to more customers using the expedited shipping service when shopping online. Furthermore, we also discover a slight increase in the overall return rate. We conclude by providing managerial implications on the functionality of the online and B&M channels and how retailers can coordinate services offered by both channels to improve the utility customers receive from the brand.
Impacts of residential fertilizer ordinances on Florida lacustrine water quality
Authors: Smidt Samuel J. , Aviles Diego , Belshe E. Fay , Reisinger Alexander J. 
Published: August 2022

AbstractDespite the assumption that residential fertilizer ordinances improve regional water quality, their impacts across space and time largely remain unknown. Here, we analyze changes in water quality of lakes throughout the State of Florida from 1987 to 2018, comparing trends in water quality parameters before and after implementation of county‐wide fertilizer ordinances. We used a large dataset of publicly collected water quality data and linear mixed models to analyze ordinance impacts on total nitrogen, total phosphorus, chlorophyll a, and Secchi depth across 160 lakes throughout Florida. We further analyze water quality impacts relative to the type of ordinance (winter fertilizer ban, summer ban, nonseasonal ban, no ban). We found fertilizer ordinances favorably impacted lacustrine water quality, and winter (dry season) fertilizer bans had the greatest effect across all water quality metrics. Results of this study can be used to support the effectiveness of fertilizer ordinances across humid tropical and subtropical climate regions.
Impact of zinc ion addition on corrosion of EH40 steel in natural seawater
Authors: Gao Yaohua , Xu Ming , Wu Jiajia , Zhang Dun , Zhu Liyang , Sun Zhihua , Li Ce 
Published: September 2022

AbstractZinc ion is a common heavy metal in marine pollution, but its impact on corrosion of steels without passive films in natural seawater is far from being investigated. In this study, the impact of zinc ion addition (1.5 and 15 mmol/L) on corrosion of EH40 steel commonly utilized for building ships and offshore platforms was studied by numerous methods and technologies. It was found that EH40 steel corrosion was inhibited with the addition of zinc ion, and corrosion inhibition efficiency increased with the concentration added. The deposited ZnO and Zn(OH)2 on the steel surface was believed to hamper electron transfer, thus inhibiting corrosion. Meanwhile, the bactericidal zinc ion and ZnO mitigated the activity of microorganisms in biofilms to reduce the damage caused by microbiologically influenced corrosion. But pitting corrosion was enhanced with a high concentration of zinc ion added due to the inhomogeneity of ZnO layers.
Longitudinal Monitoring of Progressive Supranuclear Palsy using Body‐Worn Movement Sensors
Authors: Sotirakis Charalampos , Conway Niall , Su Zi , Villarroel Mauricio , Tarassenko Lionel , FitzGerald James J. , Antoniades Chrystalina A. 
Published: August 2022

AbstractBackgroundWe have previously shown that wearable technology and machine learning techniques can accurately discriminate between progressive supranuclear palsy (PSP), Parkinson's disease, and healthy controls. To date these techniques have not been applied in longitudinal studies of disease progression in PSP.ObjectivesWe aimed to establish whether data collected by a body‐worn inertial measurement unit (IMU) network could predict clinical rating scale scores in PSP and whether it could be used to track disease progression.MethodsWe studied gait and postural stability in 17 participants with PSP over five visits at 3‐month intervals. Participants performed a 2‐minute walk and an assessment of postural stability by standing for 30 seconds with their eyes closed, while wearing an array of six IMUs.ResultsThirty‐two gait and posture features were identified, which progressed significantly with time. A simple linear regression model incorporating the three features with the clearest progression pattern was able to detect statistically significant progression 3 months in advance of the clinical scores. A more complex linear regression and a random forest approach did not improve on this.ConclusionsThe reduced variability of the models, in comparison to clinical rating scales, allows a significant change in disease status from baseline to be observed at an earlier stage. The current study sheds light on the individual features that are important in tracking disease progression. © 2022 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society