bluuebunny/crossref_metadata_2025_split huggingface dataset:
PENGORGANISASIAN PERENCANAAN DESA: KAJIAN DI DESA KALONGSAWAH KECAMATAN JASINGA KABUPATEN BOGOR
Authors: Karyana Ayi 
Published: June 2022

Development Planning Consultation (Musrenbang) Village is an annual discussion forum of villages stakeholders to agree on Village Development Work Plan (RKP Village) in the planned budget. This study aims to describe and analyze: 1) formation of Musrenbangdes Organizing Team (TPM), 2) formation of village Musrenbang Team Guide by TPM; 3) preparation of technical implementation village Musrenbang; and 4) a participatory rural assessment and dialogue. Writing method used in this study is descriptive analysis. The study shows, in the process of team formation TPM, the preparation of TPM personnel is the right and depends on the Village Head. TPM in performing their duties do not form a team or guides Working Group (WG), whereas the normative should be formed. The Working Group role and duty are process designer, managing the process from pre-to post-musrenbangdes stage, as the manager of a meeting or discussion forum and as a source of information. In the process of technical preparation through the stages of implementation, Musrenbangdes does not begin with Deliberation Hamlet (Musdus), there is no agenda for preparing the implementation plan of village workshops, Village Representative Body (BPD) does not specifically implement Musrenbangdes agenda. Village Assessment Team was not formed, so there is no village study to compile data / information on the latest village issues. Organizing musrenbang villages in the Village District Kalongsawah Jasinga Bogor Regency, ranging from the establishment of Village TPM Team Guide/ Working Group, technical preparation and review of the implementation of village meetings in a participatory and dialogical were not implemented optimally.
PEMANFAATAN UT-ONLINE OLEH MAHASISWA UNIVERSITAS TERBUKA
Authors: Sugilar Sugilar 
Published: June 2022

UT-Online is one of the internet-based student services offered by the Open University (UT) to all students. This study aims to analyze, first, the characteristics of students UT-Online users; second, knowledge of the existence of UT student-Online for each service provided in the UT-Online; Third, the behavior of the students in the use of UT-Online; and the fourth assessment of the benefits of UT student-Online. Survey is the method used in this study that managed to capture the information of 904 students through electronic mail. From this study found important matters as the following, first, the characteristics of students UT UT-Online users related to intensity of use UT-Online is the ease of accessing the internet, age, and sex, and there is a tendency that the number of UT-Online users increases with increasing student enrollment year. Secondly, each facility UT-Online has recognition rate, the use, possession, and diverse training needs. Third, each facility UT-Online can be classified based on the number of users, frequency of use, and time of access by students. Fourth, the benefit of UT-Online scores assessed the level of positive attitude of students toward the facility in the UT-Online. Related to the findings, the researchers recommend the things that can improve the quality and usefulness of UT-Online for students.

UT-Online merupakan salah satu layanan mahasiswa berbasis internet yang ditawarkan oleh Universitas Terbuka (UT) kepada seluruh mahasiswa. Penelitian ini bertujuan untuk menganalisis, pertama, karakteristik mahasiswa pengguna UT-Online; kedua, pengetahuan mahasiswa terhadap keberadaan UT-Online untuk tiap layanan yang disediakan dalam UT-Online; ketiga, perilaku mahasiswa dalam pemanfaatan UT-Online; dan keempat penilaian mahasiswa terhadap manfaat UT-Online. Survey merupakan metode yang digunakan dalam penelitian ini yang berhasil menjaring informasi dari 904 mahasiswa melalui surat elektronik. Dari penelitian ini ditemukan hal-hal penting sebagai berikut, pertama, karakteristik mahasiswa UT pengguna UT-Online yang berkaitan intensitas pemanfaatan UT-Online ialah kemudahan mengakses internet, usia, dan jenis kelamin, serta terdapat kecenderungan bahwa jumlah pengguna UT-Online meningkat sejalan dengan meningkatnya tahun masuk mahasiswa. Kedua, setiap fasilitas UT-Online memiliki tingkat pengenalan, penggunaan, penguasaan, dan kebutuhan pelatihan yang beragam. Ketiga, setiap fasilitas UT-Online dapat digolongkan berdasarkan jumlah pengguna, frekuensi penggunaan, dan lama akses oleh mahasiswa. Keempat, kemanfaatan UT-Online dinilai dalam skor tingkat sikap positif mahasiswa terhadap fasilitas dalam UT-Online tersebut. Terkait dengan temuan, peneliti merekomendasikan hal-hal yang dapat meningkatkan kualitas dan kemanfaatan UT-Online bagi mahasiswa.
An Algorithm for Accurate Marker-Based Gait Event Detection in Healthy and Pathological Populations During Complex Motor Tasks
Authors: Bonci Tecla , Salis Francesca , Scott Kirsty , Alcock Lisa , Becker Clemens , Bertuletti Stefano , Buckley Ellen , Caruso Marco , Cereatti Andrea , Del Din Silvia , Gazit Eran , Hansen Clint , Hausdorff Jeffrey M. , Maetzler Walter , Palmerini Luca , Rochester Lynn , Schwickert Lars , Sharrack Basil , Vogiatzis Ioannis , Mazzà Claudia 
Published: June 2022

There is growing interest in the quantification of gait as part of complex motor tasks. This requires gait events (GEs) to be detected under conditions different from straight walking. This study aimed to propose and validate a new marker-based GE detection method, which is also suitable for curvilinear walking and step negotiation. The method was first tested against existing algorithms using data from healthy young adults (YA, n = 20) and then assessed in data from 10 individuals from the following five cohorts: older adults, chronic obstructive pulmonary disease, multiple sclerosis, Parkinson’s disease, and proximal femur fracture. The propagation of the errors associated with GE detection on the calculation of stride length, duration, speed, and stance/swing durations was investigated. All participants performed a variety of motor tasks including curvilinear walking and step negotiation, while reference GEs were identified using a validated methodology exploiting pressure insole signals. Sensitivity, positive predictive values (PPV), F1-score, bias, precision, and accuracy were calculated. Absolute agreement [intraclass correlation coefficient (ICC2,1)] between marker-based and pressure insole stride parameters was also tested. In the YA cohort, the proposed method outperformed the existing ones, with sensitivity, PPV, and F1 scores ≥ 99% for both GEs and conditions, with a virtually null bias (&lt;10 ms). Overall, temporal inaccuracies minimally impacted stride duration, length, and speed (median absolute errors ≤1%). Similar algorithm performances were obtained for all the other five cohorts in GE detection and propagation to the stride parameters, where an excellent absolute agreement with the pressure insoles was also found (ICC2,1=0.817− 0.999). In conclusion, the proposed method accurately detects GE from marker data under different walking conditions and for a variety of gait impairments.
Gut Microbiota Signatures in Tumor, Para-Cancerous, Normal Mucosa, and Feces in Colorectal Cancer Patients
Authors: Li Yanmin , Cao Hong , Fei Bojian , Gao Qizhong , Yi Wanya , Han Weifeng , Bao Chuanqing , Xu Jianmin , Zhao Wei , Zhang Feng 
Published: June 2022

Background: Association studies have linked microbiome alterations with colorectal cancer (CRC). However, differences in tumor, para-cancerous, normal mucosal, and fecal microbiota remain to be strengthened.Methods: We performed a study on the ecologically rich and taxonomically diverse of gut microbiota using three types of colorectal mucosa (tumor mucosa, para-cancerous mucosa, normal mucosa) and feces from 98 CRC patients. Additionally, we profiled the microbiota in the fecal occult blood test (FOBT) positive and negative groups at different sampling sites.Results: We found striking variations between tumor mucosal microbiota and normal mucosal microbiota. However, there was no significant difference between tumor and para-cancerous mucosal microbiota, as well as between para-cancerous and normal mucosal microbiota, revealing that the para-cancerous mucosal microbiota was a transitional state between the tumor and normal mucosal microbiota. And the substantial shifts in the fecal microbiota compared to mucosal microbiota indicated the risk of using fecal microbiota to define mucosal microbiota. A strong correlation between FOBT positive and Fusobacterium was discovered, indicating this adherent-invasive genus was closely related to intestinal bleeding. Furthermore, we identified six key genera, including Fusobacterium, Gemella, Campylobacter, Peptostreptococcus, Alloprevotella, and Parvimonas, which appear to be consistently over-represented in tumor mucosa compared to normal mucosa and/or in mucosa compared to feces.Conclusion: Compositional alterations in the microbiota existed in three types of colorectal mucosa and feces in CRC patients. Six key genera may contribute to the topographic variances in the microbiota of tumor-bearing colorectum.
Preoperative Iron Deficiency Is Associated With Increased Blood Transfusion in Infants Undergoing Cardiac Surgery
Authors: Gao Peng , Wang Xu , Zhang Peiyao , Jin Yu , Bai Liting , Wang Wenting , Li Yixuan , Liu Jinping 
Published: June 2022

BackgroundIron deficiency (ID) is common in patients undergoing cardiac surgery, which is associated with adverse outcomes. However, the relevance of ID in congenital heart disease is still unclear. This study aimed to investigate the characteristics of preoperative ID and its association with clinical outcomes in infants undergoing cardiac surgery with cardiopulmonary bypass.MethodsIn this retrospective study, 314 patients undergoing cardiac surgery were assigned into three groups according to their preoperative ID status. Absolute ID was defined by serum ferritin &lt;12 μg/L, and functional ID was defined by serum ferritin level at 12–30 μg/L and transferrin saturation &lt;20%. Baseline characteristics were compared between groups and multiple logistic regression was used to identify predictors for ID. The association between ID and clinical outcomes, including allogenic blood transfusion requirements, was also evaluated.ResultsAmong the 314 patients included, 32.5% were absolute ID and 28.7% were functional ID. Patients with absolute ID were more often of higher weight, cyanotic heart disease, and anemia. The presence of absolute ID was associated with an increase in postoperative blood transfusion (OR 1.837, 95% CI 1.016–3.321, p = 0.044). There was no significant difference in postoperative morbidity, mortality, and the length of hospital stay.ConclusionsAbsolute ID was associated with preoperative anemia and cyanotic heart disease, and was an independent risk factor for postoperative blood transfusion. Further research should better explore the definition of ID and its impact on outcomes in pediatric cardiac surgery.
RJX Improves Wound Healing in Diabetic Rats
Authors: Uckun Fatih M. , Orhan Cemal , Tuzcu Mehmet , Durmus Ali Said , Ozercan Ibrahim H. , Volk Michael , Sahin Kazim 
Published: June 2022

BackgroundWe recently reported the clinical safety profile of RJX, a well-defined intravenous GMP-grade pharmaceutical formulation of anti-oxidant and anti-inflammatory vitamins as active ingredients, in a Phase 1 study in healthy volunteers (ClinicalTrials.gov Identifier: NCT03680105) (Uckun et al., Front. Pharmacol. 11, 594321. 10.3389/fphar.2020.594321). The primary objective of the present study was to examine the effects of GMP-grade RJX on wound and burn injury healing in diabetic rats.MethodsIn the present study, a rat model of T2DM was used that employs HFD in combination with a single injection of STZ intraperitoneally (i.p) at a moderate dose level (45 mg/kg). Anesthetized diabetic rats underwent full-thickness skin excision on the back or were subjected to burn injury via a heated brass probe and then started on treatments with normal saline (NS = vehicle) or RJX administered via intraperitoneal injections for three weeks.FindingsNotably, diabetic rats treated with the 1.25 mL/kg or 2.5 mL/kg RJX (DM+RJX groups) rapidly healed their wounds as fast as non-diabetic control rats. Inflammatory cell infiltration in the dermis along with fibrin and cell debris on the epithelial layer persisted for up to 14 days in the DM+NS group but not in RJX-treated groups. The histopathological score of wound healing on days 7 and 14 was better in diabetic rats treated with RJX than diabetic rats treated with NS and comparable to the scores for non-diabetic healthy rats consistent with an accelerated healing process. The residual wound area of RJX-treated rats was significantly smaller than that of NS-treated diabetic rats at each evaluation time point (P&lt;0.001). The accelerating effect of RJX on diabetic wound healing was dose-dependent. We obtained similar results in the burn injury model. Our results demonstrate that RJX – at a dose level &gt;10-fold lower than its clinical maximum tolerated dose (MTD) – accelerates the healing of excision wounds as well burn injury in diabetic rats.
Integrative Analysis Identifies a TNFα-Derived Gene Signature for Predicting Prognosis, Tumor Immunity, and Treatment Sensitivity in Gastric Cancer
Authors: Wang Ke , Qi Lina , Sun Hua , Diao Min , Yang Lin 
Published: June 2022

Objective: TNF-α is an essential pro-inflammatory cytokine in the tumor microenvironment of gastric cancer (GC), possessing a key biological and clinical impact. Here, we conducted an integrative analysis of the role of TNFα-derived genes in GC prognosis and precision medicine.Methods: We pooled transcriptome and clinical features of GC patients from TCGA and GSE15459 projects. TNFα signaling was quantified through the ssGSEA algorithm, and TNFα-derived genes were screened with WGCNA. Thereafter, a LASSO model was established. The somatic mutation was analyzed across GC specimens. Immune cell infiltrations were inferred through ESTIMATE and ssGSEA algorithms, followed by measuring the immune checkpoint expression. AKR1B1, CPVL, and CTSL expressions were measured in gastric mucosal cells GES-1 and GC cells (HGC-27, MKN-28, and AGS) through RT-qPCR and Western blotting.Results: A TNFα-derived gene signature (containing AKR1B1, CPVL, and CTSL) was developed for GC. A high-risk score indicated more undesirable OS, DFS, DSS, and PFS outcomes. Time-independent ROC curves and multivariate cox regression models confirmed that the signature reliably and independently predicted GC prognosis. Additionally, risk scores displayed significant correlations to more severe histological grades and pathological stages. A low-risk score was characterized by increased somatic mutation, while a high-risk score was characterized by immune and stromal activation, enhanced immune cell infiltrations, and increased expression of immune checkpoint molecules. Experimental results confirmed the significant upregulation of AKR1B1, CPVL, and CTSL in GC cells.Conclusion: Collectively, stratification based on the TNFα-derived gene signature might enable GC patients to predict prognosis, benefit from immunotherapy, and assist in formulating novel therapeutic regimens.
Neoadjuvant Pembrolizumab and Chemotherapy in Resectable Esophageal Cancer: An Open-Label, Single-Arm Study (PEN-ICE)
Authors: Duan Hongtao , Shao Changjian , Pan Minghong , Liu Honggang , Dong Xiaoping , Zhang Yong , Tong Liping , Feng Yingtong , Wang Yuanyuan , Wang Lu , Newman Neil B. , Sarkaria Inderpal S. , Reynolds John V. , De Cobelli Francesco , Ma Zhiqiang , Jiang Tao , Yan Xiaolong 
Published: June 2022

BackgroundIn this single-arm study, the efficacy and safety of neoadjuvant pembrolizumab plus chemotherapy were evaluated in patients with resectable esophageal squamous cell carcinoma (ESCC).MethodsThis study included patients with ESCC of clinical stages II–IVA who underwent surgery within 4 to 6 weeks after completing treatment with pembrolizumab (200 mg) combined with a conventional chemotherapy regimen (3 cycles). The safety and efficacy of this combination treatment were evaluated as primary endpoints of the study.ResultsFrom April 2019 to August 2020, a total of 18 patients (including 14 men) were enrolled, of whom 13 patients progressed to surgery. Postoperative pathology revealed a major pathological response (MPR) in 9 cases (9/13, 69.2%) and a pathological complete response (pCR) in 6 cases (6/13, 46.2%). Five patients (5/18, 27.8%) experienced serious treatment-related adverse events (AEs) of grades 3–4. At the time of data cutoff (Mar 25, 2022), the shortest duration of follow-up was 17.8 months. Programmed death-ligand 1 (PD-L1) expression in pretreatment specimens was not significantly associated with the percentage of residual viable tumor (RVT) (r=−0.55, P=0.08). Changes in counts of CD68+ macrophage between pre- and post-treatment specimens were weakly correlated with RVT (r=0.71; P=0.07), while a positive correlation was observed between postoperative forkhead box P3-positive (Foxp3)+T cells/CD4+Tcells ratios and RVT (r=0.84, P=0.03).ConclusionsThe combination of neoadjuvant immunotherapy and chemotherapy for ESCC is associated with a high pathological response and immunologic effects in the tumor microenvironment (TME). It has acceptable toxicity and great efficacy, suggesting a strong rationale for its further evaluation in randomized clinical trials (RCTs).Trial RegistrationChiCTR2100048917.
Some Distinct Features of Transformative High Entropy Alloys for Metal Additive Manufacturing
Authors: Nene S.S. 
Published: June 2022

Sudden damage in engineering materials during service was always a challenge, and a lot of efforts have been put forward by materials scientists to resolve this issue. This motivated the design of a variety of classes of alloys such as stainless steel, deformed and partitioned steels, metastable Ti alloys, and recently developed high entropy alloys (HEA). A continuous evolving journey from single-phase to multi-phase HEAs showed exceptional work hardenability in them, which is required for improved failure resistance in metallic systems. In line with that, recently developed transformative high entropy alloys (T-HEAs) displayed interesting outcomes in terms of improved damage tolerance (σUTS ∼1.2 GPa and ductility ∼20% with 1.5% defect density) after conventional processing, severe deformation, and laser-assisted 3D printing. These outcomes were attributed to the localized WH activity within the stress concentration regions due to the activation of transformation induced plasticity (TRIP) effect near the defects. As a result, defects present in these T-HEAs act as sites for delaying the damage by showing a pronounced transformation induced crack retardation (TRICR) effect, thereby improving failure resistance during service.
Influence of Ammonia on the Corrosion Behavior of a Zr–Sn–Nb Alloy in High Temperature Water
Authors: Chen Zirui , Zhao Yongfu , Tang Min , Yin Zhaohui , Gong Bin , Wu Zongpei 
Published: June 2022

Corrosion behaviors, microstructures of oxide films, and hydrogen absorptions of a Chinese domestic Zr alloy in 6.7 × 10−3 mol/L ammonia solution and 2.9 × 10−4 mol/L LiOH+9.3 × 10−2 mol/L H3BO3 solution at 360 °C, 18.6 MPa were studied. Weight gains, oxide film thicknesses, and hydrogen absorptions showed that the corrosion rate in the ammonia solution is a little higher than that in the boron–lithium solution. There is no significant difference in the microstructure and crystalline structure between the oxide films formed in the two types of solutions. The element distributions along the depth direction of the oxide films showed the existence of nitrogen in the oxide film formed in ammonia solution. Moreover, nitrogen was found to be segregated in local areas in a range of about 2 μm from the oxide/metal interface. The corrosion behavior of the Chinese domestic Zr alloy in 360 °C aqueous solution shows no difference with other Zr alloys.
Rare c-KIT c.1926delA and c.1936T>G Mutations in Exon 13 Define Imatinib Resistance in Gastrointestinal Stromal Tumors and Melanoma Patients: Case Reports and Cell Experiments
Authors: Yan Chi , Zhao Chengzhi , Yang Ke , Zhou Hongyan , Jing Limin , Zhao Weixing , Dou Wenguang , Xia Qingxin , Ma Jie , Wei Bing , Guo Yongjun 
Published: June 2022

Background: Target therapies play more and more important roles in gastrointestinal stromal tumors (GISTs) and melanoma with the advancement of clinical drugs that overcome the resistance caused by gene mutations. c-KIT gene mutations account for a large portion of GIST patients, which are known to be sensitive or resistant to tyrosine kinase inhibitors. However, the role rare mutations play in drug efficacy and progression-free duration remains elusive.Methods: Two rare mutations were identified using Sanger sequencing from the GIST and melanoma cases. Cell experiments were further carried out to demonstrate their role in the imatinib resistance.Results:c-KIT c.1926delA p.K642S*FS mutation in primary and recurrent GIST patients and c-KIT c.1936T&gt;G p.Y646D point mutation in melanoma patients in exon 13 were first demonstrated to be novel targets resistant to imatinib agent.Conclusion:c-KIT mutations c.1926delA and c.1936T&gt;G in exon 13 are clinically significant targets that exhibit resistance to imatinib. This study provides guidance to GIST and melanoma treatments.
Reorganization of the Brain Structural Covariance Network in Ischemic Moyamoya Disease Revealed by Graph Theoretical Analysis
Authors: Wang Peijing , Li Wenjie , Zhu Huan , Liu Xingju , Yu Tao , Zhang Dong , Zhang Yan 
Published: June 2022

ObjectiveIschemic moyamoya (MMD) disease could alter the cerebral structure, but little is known about the topological organization of the structural covariance network (SCN). This study employed structural magnetic resonance imaging and graph theory to evaluate SCN reorganization in ischemic MMD patients.MethodForty-nine stroke-free ischemic MMD patients and 49 well-matched healthy controls (HCs) were examined by T1-MPRAGE imaging. Structural images were pre-processed using the Computational Anatomy Toolbox 12 (CAT 12) based on the diffeomorphic anatomical registration through exponentiated lie (DARTEL) algorithm and both the global and regional SCN parameters were calculated and compared using the Graph Analysis Toolbox (GAT).ResultsMost of the important metrics of global network organization, including characteristic path length (Lp), clustering coefficient (Cp), assortativity, local efficiency, and transitivity, were significantly reduced in MMD patients compared with HCs. In addition, the regional betweenness centrality (BC) values of the bilateral medial orbitofrontal cortices were significantly lower in MMD patients than in HCs after false discovery rate (FDR) correction for multiple comparisons. The BC was also reduced in the left medial superior frontal gyrus and hippocampus, and increased in the bilateral middle cingulate gyri of patients, but these differences were not significant after FDR correlation. No differences in network resilience were detected by targeted attack analysis or random failure analysis.ConclusionsBoth global and regional properties of the SCN are altered in MMD, even in the absence of major stroke or hemorrhagic damage. Patients exhibit a less optimal and more randomized SCN than HCs, and the nodal BC of the bilateral medial orbitofrontal cortices is severely reduced. These changes may account for the cognitive impairments in MMD patients.