bluuebunny/crossref_metadata_2025_split huggingface dataset:
Socio-economic factors influencing the adoption of low carbon technologies under rice production systems in China
Authors: Chen Zhong-Du , chen fu 
Published: August 2022

Abstract
[Background] Rice (Oryza sativa L.) is the prominent cereal crop in Hunan Province (HP), which is a major rice production area in China. Rice production, such as farmers’ livelihood and the soil quality, has been identified to be influenced by climate change. Low carbon technologies (LCTs) have been identified to tackle agricultural challenges; however, the benefits of LCTs for farmers in rice production are still debatable. The choice of potential LCTs relevant to the case study is based on a literature review of previous empirical studies. Thus, the objective of the study were to 1) investigate the public perception and preferences of LCTs in rice production of HP, and 2) analyze the influences of the factors on farmer’s decision in adopting LCTs in rice production. There were 555 farmer surveys from eight representative rice production counties in HP, both the poisson estimators and multivariate probit (MVP) approach were applied in the study. [Results] Our results show that water-saving irrigation, integrated pest management techniques and planting green manure crops in winter season were the three major LCTs adapted by farmers in rice production in HP. Both the intensity and probability of the adoptions of LCTs were affected by the main factors including farmers’ education level, climate change awareness, machinery ownership, technical support and subsidies. There is a significant correlation among the LCTs, and the adoption of the technologies is interdependent, depicting either complementarities or substitutabilities between the practices. [Conclusions] This study suggests that policies enhance the integration of LCTs would be central to farmers’ knowledge, environmental concerns, technical service and financial support in rice production systems in China.
Effects of Different Progesterone Containing Contraceptive Methods on Safety and Endogenous Progesterone Level: A Prospective Cohort Study
Authors: Osman Ahmed , Omar Mona 
Published: August 2022

Abstract
Background
Progestogen-only contraceptives are presented as injections, implants, oral formulations, hormone-releasing intrauterine methods, and emergency contraceptives. This study assessed the effect of different progesterone-containing contraceptive methods on safety and endogenous progesterone level.
Methods
This prospective cohort study included 80 healthy fertile females aged between 20 and 35 years with normal menstrual history who had at least one offspring after spontaneous pregnancy. Subjects were divided into four equal groups according to the contraceptive method: group D (Depo-Provera®) used the injectable progesterone of 150 mg every 90 days or 3 months, group I contained 68 mg of etonogestrel implant formerly known as Implanon, group N: used norgestrel (Ovrette®), (each pill contains 0.075 mg of norgestrel) once daily, and group M: used intrauterine device (IUD) (Mirena) containing 52 mg of levonorgestrel.
Results
Group M had a higher endogenous progesterone level compared to those who used other contraceptives with a normal follicle size. Incidence of amenorrhea was significantly lower in group M (20%) than in group D (75%), group I (65%), and group N (70%), with an insignificant difference among the other three groups. Continuation rate had significantly increased in group M than in the other three groups after 6 months. Efficacy was insignificantly different among the four groups.
Conclusion
Mirena had low systemic absorption of exogenous progesterone, so it had less effect on endogenous progesterone with better follicle size and low incidence of side effects (amenorrhea) compared to other contraceptives containing progesterone.
Entrepreneurs' perception: the connection of the brand with the Amazon Forest business
Authors: Diego Luiz , Sandro Francisco , Paula Ana 
Published: August 2022

Abstract
The objective of this study was to understand the perception of entrepreneurs based on their business model related to the connection of the Amazon brand. There is a need to present an entrepreneurial perspective on the brand´s changes and their long-term relationships between the Forest and the environmental sustainability on the Brazilian Amazon. The study consisted of semi-structured interviews with 1 out of 7 companies operating in the Amazon region. Brands that develop sustainable businesses in the Brazilian Amazon, with their brand equity based on the region's environmental responsibility, brought an understanding that a full performance of sustainable activities depends on the performance of three agents: entrepreneurs, native peoples and management. Entrepreneurs perceive a greater valuation of their products associated with the sustainability of the Amazon introduced in the brand experience by the customer.
Effects of CYP3A4/5 and ABC transporter polymorphisms on osimertinib plasma concentrations in Japanese patients with non-small cell lung cancer
Authors: Yokota Hayato , Sato Kazuhiro , Sakamoto Sho , Okuda Yuji , Fukuda Natsuki , Asano Mariko , Takeda Masahide , Nakayama Katsutoshi , Miura Masatomo 
Published: August 2022

Abstract
Background
The effects of polymorphisms in CYP3A4 (20230G > A), CYP3A5 (6986A > G), ABCB1 (1236C > T, 2677G > T/A, 3435C > T), ABCG2 (421C > A), and ABCC2 (-24C > T) on the area under the concentration-time curve (AUC) of osimertinib in 23 patients with non-small cell lung cancer were investigated.
Methods
Blood sampling was performed just prior to and at 1, 2, 4, 6, 8, 12, and 24 h after osimertinib administration at the steady-state on day 15 after beginning therapy.
Results
There were significant correlations of the osimertinib AUC0-24 with age (P = 0.038), serum albumin (P = 0.002), and serum creatinine (P = 0.012). Additionally, there were significant differences in the AUC0-24 of osimertinib among the groups administered vonoprazan, histamine 2-receptor antagonists or esomeprazole, and no acid suppressants (P = 0.021). By contrast, there were no significant differences in the AUC0-24 of osimertinib between genotypes of CYP3A4/5 or ABC transporters. Furthermore, there were no significant differences in the AUC0-24 of osimertinib between patients with diarrhea, skin rash, or hepatotoxicity and those without these conditions. In multivariate analysis, only serum albumin value was an independent factor predicting the AUC0-24 of osimertinib.
Conclusions
Analysis of CYP3A4/5 and ABC transporter polymorphisms before osimertinib therapy may not predict the efficacy or side effects of osimertinib. However, lower serum albumin values were associated with an increase in the AUC0 − 24 of osimertinib. After beginning osimertinib therapy, periodic measurement of serum albumin values should be performed.
Risk of urinary tract infection in patients with type 2 diabetes treated with dapagliflozin: A systematic review and meta-analysis of randomized controlled studies
Authors: Zheng Zhigui , He Dongyuan , Chen Jianguo , Xie Xiaohui , Lu Yunan , Wu Binbin , Jiang Xinxin 
Published: August 2022

Abstract
As a selective inhibitor of sodium-glucose cotransporter 2, dapagliflozin is widely used in the treatment of type 2 diabetes mellitus (T2DM). However, whether it increases the risk of urinary tract infection (UTI) remains an ongoing issue. Therefore, we performed a systematic review and meta-analysis of randomized clinical trials (RCTs) to estimate the short-term and long-term risks of UTI in patients with T2DM who received dapagliflozin at different doses.
As a selective inhibitor of sodium-glucose cotransporter 2, dapagliflozin is widely used in the treatment of type 2 diabetes mellitus (T2DM). However, whether it increases the risk of urinary tract infection (UTI) remains an ongoing issue. Therefore, we performed a systematic review and meta-analysis of randomized clinical trials (RCTs) to estimate the short-term and long-term risks of UTI in patients with T2DM who received dapagliflozin at different doses. We searched the PubMed, EMBASE, the Cochrane Library and ClinicalTrials.gov website from each database's inception to December 2021. The review protocol was previously registered in the PROSPERO database (CRD42022299899). A total of 40 RCTs involving 35573 patients were assessed for eligibility. The results showed that dapagliflozin imposed a higher risk of UTI compared to placebo and other active treatments, with a heterogeneity of 11% (OR 1.17, 95% CI 1.04-1.31, P=0.006). In the subgroup analysis, dapagliflozin 10 mg/d with a treatment period >24 weeks was associated with a significantly higher UTI risk than placebo or other active treatments (OR 1.27, 95% CI 1.13-1.43, P＜0.0001). The ORs for dapagliflozin as monotherapy and combination therapy in the control group were 1.05 (95% CI 0.88-1.25, P=0.571) and 1.27 (95% CI 1.09-1.48, P=0.008), respectively. Overall, dapagliflozin 10 mg daily with a treatment duration of more than 24 weeks may significantly increase the risk of UTI in patients with T2DM. The combination of dapagliflozin and other glucose-lowering drugs might be associated with a higher risk of UTI. Therefore, high-dose, long-term treatment and add-on therapy of dapagliflozin call for careful consideration of the risk of UTI in T2DM patients.
Effects of zinc doping on current-voltage and capacitance-voltage-frequency characteristics of n-silicon Schottky diode
Authors: Oeba D. A. , Bodunrin J. O. , Moloi S. J. 
Published: August 2022

Abstract

The electrical properties of diodes fabricated on undoped and zinc-dopedn-silicon were investigated in this study using current-voltage (I-V) and capacitance-voltage-frequency (C-V-f) techniques. The diode’s forward current decreased by a factor of ~ 3, while the reverse current increased by a factor of ~ 37, confirming that the charge carrier recombination/ compensation is due to the generation of minority carrier to increase the resistivity of the material upon doping with zinc (Zn). The generation of the minority carrier was confirmed by inversion of the material conductivity formn- top-type, as shown by C-Vresults. Furthermore, the findings reveal that Zn is responsible for a reduction in full depletion voltage (FDV), implying that the space charge region (SCR) width can be fully depleted with a relatively low applied voltage. For the manufacturing of sensitive radiation detectors, a low FDV is critical. A change in the electrical properties of the diode was explained in terms of defects induced in the Si bulk by Zn. The properties of Zn-dopedn-Si-based diodes are similar to those of radiation-hard Si devices. In general, the findings suggest that Zn might be employed as a possible dopant in a study to improve the characteristics of Si to fabricate radiation-hard and sensitive detectors for current and future high energy physics experiments.
Influencing factors of perioperative blood loss in intertrochanteric femoral fractures treated with intramedullary nail: a retrospective case control study
Authors: Hao Zeyu , Sun Jiantao , Wang Jiantao , Liu Mingwei , Liu Minghui 
Published: August 2022

Abstract
Background
As society ages and the incidence of periprosthetic fractures continues to rise, hemoglobin (HGB) levels are closely associated with the incidence of perioperative complications and mortality of intertrochanteric femoral fractures (ITFs), and effective assessment of changes in HGB levels may be critical to reducing the incidence of complications and mortality.
Methods
We retrospectively collected clinical data of ITFs treated with PFNA at our institution. Perioperative HGB, fracture type, operation time, whether limited open reduction was used, and other general characteristics of the patients were documented. The independent risk factors causing HGB drop were studied using multiple linear regression.
Results
Preoperative and postoperative HGB were substantially lower in the unstable group, and HGB drop was significantly larger in the unstable group than in the stable group. The unstable group's limited open reduction rate was significantly higher than the stable group's. Age, operation time, intraoperative limited open reduction, and fracture type were all independent risk factors for HGB drop, with age being negatively connected and the rest being positively correlated.
Conclusion
In ITFs patients treated with PFNA, HGB drop could indicate perioperative blood loss. It is much more important to be vigilant to changes in HGB in unstable fractures and younger patients; operation time should be minimized, and unnecessary restricted open reduction should be avoided to minimise blood loss.
Learning and Navigating Digitally-Rendered Haptic Spatial Layouts
Authors: Tivadar Ruxandra , Franceschiello Benedetta , Minier Astrid , Murray Micah 
Published: August 2022

Abstract

Learning spatial layouts and navigating through them rely not simply on sight, but rather on multisensory processes, including touch. Digital haptics are effective for creating and manipulating mental images of individual objects in sighted and visually impaired participants. Here, we tested if this extends to scenes and navigation within them. Using only digital haptics, sighted blindfolded participants first learned the basic layout of an apartment and then one of two pathways through it. While still blindfolded, participants successfully reconstructed the haptically learned 2D spaces and also navigated these spaces. Digital haptics were thus an effective means to learn and translate 2D images into 3D reconstructions of layouts and actions within real spaces. Digital haptics are thus an alternative learning tool for complex scenes as well as for successful navigation in previously unfamiliar layouts, which can likely be further applied in rehabilitation of spatial functions and mitigation of visual impairments.
Supercooling of the A phase of 3He}
Authors: Tian Yefan , Lotnyk Dmytro , Eyal Anna , Zhang Kuang , Zhelev Nikolay , Abhilash T. , Chavez Aldo , Smith Eric , Hindmarsh Mark , Saunders John , Mueller Erich , Parpia Jeevak 
Published: August 2022

Abstract
Because of the extreme purity, lack of disorder, and complex order parameter, the first-order superfluid 3He A-B transition is the leading model system for first order transitions in the early universe. Here we report on the path dependence of the supercooling of the A phase over a wide range of pressures below 29.3 bar at nearly zero magnetic field. The A phase can be cooled significantly below the thermodynamic A-B transition temperature. While the extent of supercooling is highly reproducible, it depends strongly upon the cooling trajectory: The metastability of the A phase is enhanced by transiting through regions where the A phase is more stable. We provide evidence that some of the additional supercooling is due to the elimination of B phase seeds formed upon passage through the superfluid transition.
A greater understanding of the physics is essential before the 3He can be exploited to model transitions in the early universe.
Directly Batch-Manufacturing of Flexible Sensors for Soft Manipulator Based on Graphene-Nanosheets Film
Authors: Zhang Xi , Huang Wenhao , Lv Chaoyang , Zeng Ruifeng , Zhang Yu , Zhang Jichen , Wen Bo , Diao Dongfeng 
Published: August 2022

Abstract
One of the fundamental problems in direct manufacturing of flexible devices is the low-melting temperature of flexible substrate which hinders the development of flexible electronics. Here, we proposed an ECR sputtering system which can directly batch fabricate devices on flexible substrate under a low temperature, by virtue of the unique plasma generation mode of ECR and the polariton energy-transfer mode between the plasma and the substrate surface. The preparation temperature is accurately controlled within 100 ~ 400 ℃. The films have the good uniformity of distribution in a large size (17×17 mm2). The Ra roughness is 20 ~ 30 nm. Flexible graphene nanosheets embedded carbon (F-GNEC) films are directly manufactured on materials such as PI, PET, PDMS, etc. The batch manufacturing was obtained with a linewidth of 18 µm and the wafer size of 2 inch (8×8 sensors). We investigated the effects of three manufacturing parameters: substrate bias (electron energy), microwave power (plasma flux and energy), and magnetic field (electron flux) on the nanostructure of F-GNEC films. Finally, the tensile tensor and angle sensor for machine hand of F-GNEC film was studied and the theoretical mechanism of the polariton energy-transfer mode of the quantum manufacturing was discussed.
Impact of cataract surgery on income in rural Southern China: the SUCCESS randomised controlled trial
Authors: Tan Xuhua , Han Xiaotong , Zheng Yingfeng , Jin Ling , Qiu Xiaozhang , Zhu Yi , Chen Chuan , Zhang Jiaqing , Dickey Heather , Wang Decai , Huang Shengsong , Liu Bin , liang xiaoling , Zeng Yangfa , Lin Haotian , He Mingguang , Luo LiXia , Huang Wenyong , congdon nathan , Liu Yizhi 
Published: August 2022

Abstract

Purpose Visual impairment from cataract is closely associated with low income, but trial evidence regarding impact of surgery on income is lacking. We investigated whether cataract surgery could increase personal income. Methods This is a two-arm, parallel-group, open-label, randomised controlled trial (ClinicalTrials.gov, NCT03020056). Persons aged ≥50 years in rural Guangdong, China, with best-corrected visual acuity < 6/19 in both eyes due to cataract were randomly assigned (1:1) to receive surgery within four weeks (intervention group), or one year later (control). All participants were interviewed at baseline and end-line regarding demographic characteristics, income and quality of life. Results Among the 292 eligible persons (5.40%, mean age 74.0 years, 61.0% women) randomly assigned to intervention (n=146) or control (n=146),12 intervention group participants (8.22%) and one control (0.68%) did not receive the allocated intervention. By study closeout, 18 participants (6.16%) were lost to follow-up. Mean one-year intervention group income increase (USD2469 to 3588; change: USD1119) was significantly larger than for controls (USD2258 to 2052; change: USD-206), a between-group difference of USD1325 (relative increase 54.0%, 95% Confidence Interval [CI]: USD739 to 1911, p<0.001). In multivariable modeling, intervention group membership was associated with greater income increase (β=1143.2, 95%CI: 582.0 to 1704.3; p<0.001). Greater improvement in best-corrected visual acuity was associated with income increase in univariable modeling (β=1626.9, 95%CI: 1083.6 to 2170.1; p<0.001).Conclusions Cataract surgery substantially increases personal income in rural China, offering a strategy for poverty alleviation. The strong association between increased income and change in visual acuity enhances biological plausibility of the result.
Antenatal care and health behavior of pregnant women - An evaluation of the Survey of Neonates in Pomerania
Authors: Mahlo-Nguyen Janine , Heckmann Matthias , Pierdant Guillermo , Allenberg Heike , Ittermann Till , Lange Anja Erika 
Published: August 2022

Abstract
Background. The German maternity guidelines require regular medical checkup (MC) during pregnancy as a measure of prevention. Socioeconomic factors such as education, profession, income and origin, but also age and parity may influence the preventive and health behavior of pregnant women. The aim was to investigate the influence of these factors on the participation rate in MC of pregnant women.Method. The current analysis is based on the prospective population-based birth cohort study Survey of Neonates in Pomerania, which was conducted in Western Pomerania, Germany. The data of 4092 pregnant women from 2004 to 2008 were analyzed regarding the antenatal care and health behavior. Up to 12 MC were regularly offered; participation in 10 MC is defined as standard screening according to maternity guidelines.Results. Women participated in the first preventive MC on average in the 10th (± 3.8 SD) week of pregnancy. 1343 (34.2 %) women participated in standard screening and 2039 (51.9 %) took a screening above standard. 547 (13.92 %) women participated in less than the 10 standard MCs. In addition, about one-third of the pregnancies investigated in this study were unplanned. Bivariate analyses showed an association between better antenatal care behavior and higher maternal age, stabile partnerships and mother born in Germany, p < .05. On the contrary antenatal care below standard were more often found by women with unplanned pregnancies, less educational women and women with lower equivalent income, p < .001. Health behaviors also influenced antenatal care. Whereas, the risk of antenatal care below standard increased by smoking during pregnancy (RRR 1.64; 95% CI 1.25, 2.14) and alcohol consumption (RRR 1.31; 95% CI 1.01, 1.69), supplementation intake was associated with decreased risk (iodine - RRR 0.66; 95% CI 0.53, 0.81; folic acid - RRR 0.56; 95% CI 0.44, 0.72). The health behavior of pregnant women also differs according to their social status. Higher maternal income was negatively correlated with smoking during pregnancy (OR 0.2; 95% CI 0.15, 0.24), but positively associated with alcohol consumption during pregnancy (OR 1.3; 95% CI 1.15, 1.48) and lower pre-pregnancy BMI (Coef. = .083, p < .001). Lower maternal education was positively correlated with smoking during pregnancy (OR 59.0; 95% CI 28.68, 121.23).Conclusions. Prenatal care according to maternity guidelines is well established with a high participation rate in MC during pregnancy of more than 85%. However, targeted preventive measures may address younger age, socioeconomic status and health-damaging behaviors (smoking, drinking) of the pregnant women because these factors were associated with antenatal care below standard.