bluuebunny/crossref_metadata_2025_split huggingface dataset:
Using lower-redshift, non-CMB, data to constrain the Hubble constant and other cosmological parameters
Authors: Cao Shulei , Ratra Bharat 
Published: April 2022

Abstract
We use updated Hubble parameter and baryon acoustic oscillation data, as well as other lower-redshift Type Ia supernova, Mg ii reverberation-measured quasar, quasar angular size, H ii starburst galaxy, and Amati-correlated gamma-ray burst data, to jointly constrain cosmological parameters in six cosmological models. The joint analysis provides model-independent determinations of the Hubble constant, H0 = 69.7 ± 1.2 $\rm {km \ s^{-1} \ Mpc^{-1}}$, and the current non-relativistic matter density parameter, Ωm0 = 0.295 ± 0.017. These error bars are factors of 2.2 and 2.3 larger than the corresponding error bars in the flat ΛCDM model from Planck TT,TE,EE+lowE+lensing cosmic microwave background anisotropy data. Based on the deviance information criterion (DIC), the flat ΛCDM model is most favored but mild dark energy dynamics and a little spatial curvature are not ruled out.
The role of nucleoside triphosphate hydrolase metallochaperones in making metalloenzymes
Authors: Vaccaro Francesca A , Drennan Catherine L 
Published: April 2022

Abstract
Metalloenzymes catalyze a diverse set of challenging chemical reactions that are essential for life. These metalloenzymes rely on a wide range of metallocofactors, from single metal ions to complicated metallic clusters. Incorporation of metal ions and metallocofactors into apo-proteins often requires the assistance of proteins known as metallochaperones. Nucleoside triphosphate hydrolases (NTPases) are one important class of metallochaperones and are found widely distributed throughout the domains of life. These proteins use the binding and hydrolysis of nucleoside triphosphates, either adenosine triphosphate or guanosine triphosphate, to carry out highly specific and regulated roles in the process of metalloenzyme maturation. Here, we review recent literature on NTPase metallochaperones and describe the current mechanistic proposals and available structural data. By using representative examples from each type of NTPase, we also illustrate the challenges in studying these complicated systems. We highlight open questions in the field and suggest future directions. This minireview is part of a special collection of articles in memory of Professor Deborah Zamble, a leader in the field of nickel biochemistry.
Leptomeningeal disease and tumor dissemination in a murine diffuse intrinsic pontine glioma model: implications for the study of the tumor-cerebrospinal fluid-ependymal microenvironment
Authors: Pan Shelei , Ye Dezhuang , Yue Yimei , Yang Lihua , Pacia Christopher P , DeFreitas Dakota , Esakky Prabagaran , Dahiya Sonika , Limbrick David D , Rubin Joshua B , Chen Hong , Strahle Jennifer M 
Published: April 2022

Abstract

Background
Leptomeningeal disease and hydrocephalus are present in up to 30% of patients with diffuse intrinsic pontine glioma (DIPG), however there are no animal models of cerebrospinal fluid (CSF) dissemination. As the tumor–CSF–ependymal microenvironment may play an important role in tumor pathogenesis, we identified characteristics of the Nestin-tumor virus A (Nestin-Tva) genetically engineered mouse model that make it ideal to study the interaction of tumor cells with the CSF and its associated pathways with implications for the development of treatment approaches to address CSF dissemination in DIPG.

Methods
A Nestin-Tva model of DIPG utilizing the 3 most common DIPG genetic alterations (H3.3K27M, PDGF-B, and p53) was used for this study. All mice underwent MR imaging and a subset underwent histopathologic analysis with H&E and immunostaining.

Results
Tumor dissemination within the CSF pathways (ventricles, leptomeninges) from the subependyma was present in 76% (25/33) of mice, with invasion of the choroid plexus, disruption of the ciliated ependyma and regional subependymal fluid accumulation. Ventricular enlargement consistent with hydrocephalus was present in 94% (31/33). Ventricle volume correlated with region-specific transependymal CSF flow (periventricular T2 signal), localized anterior to the lateral ventricles.

Conclusions
This is the first study to report CSF pathway tumor dissemination associated with subependymal tumor in an animal model of DIPG and is representative of CSF dissemination seen clinically. Understanding the CSF–tumor–ependymal microenvironment has significant implications for treatment of DIPG through targeting mechanisms of tumor spread within the CSF pathways.
DOMINANT AWN INHIBITOREncodes the ALOG Protein Originating from Gene Duplication and Inhibits AWN Elongation by Suppressing Cell Proliferation and Elongation in Sorghum
Authors: Takanashi Hideki , Kajiya-Kanegae Hiromi , Nishimura Asuka , Yamada Junko , Ishimori Motoyuki , Kobayashi Masaaki , Yano Kentaro , Iwata Hiroyoshi , Tsutsumi Nobuhiro , Sakamoto Wataru 
Published: April 2022

AbstractThe awn, a needle-like structure extending from the tip of the lemma in grass species, plays a role in environmental adaptation and fitness. In some crops, awns appear to have been eliminated during domestication. Although numerous genes involved in awn development have been identified, several dominant genes that eliminate awns are also known to exist. For example, in sorghum (Sorghum bicolor), the dominant awn-inhibiting gene has been known since 1921; however, its molecular features remain uncharacterized. In this study, we conducted quantitative trait locus analysis and a genome-wide association study of awn-related traits in sorghum and identified DOMINANT AWN INHIBITOR (DAI), which encodes the ALOG family protein on chromosome 3. DAI appeared to be present in most awnless sorghum cultivars, likely because of its effectiveness. Detailed analysis of the ALOG protein family in cereals revealed that DAI originated from a duplication of its twin paralog (DAIori) on chromosome 10. Observations of immature awns in near-isogenic lines revealed that DAI inhibits awn elongation by suppressing both cell proliferation and elongation. We also found that only DAI gained a novel function to inhibit awn elongation through an awn-specific expression pattern distinct from that of DAIori. Interestingly, heterologous expression of DAI with its own promoter in rice inhibited awn elongation in the awned cultivar Kasalath. We found that DAI originated from gene duplication, providing an interesting example of gain-of-function that occurs only in sorghum but shares its functionality with rice and sorghum.
Treatment of chikungunya-associated joint pain: a systematic review of controlled clinical trials
Authors: Rodrigo Chaturaka , Herath Tharuka , Wickramarachchi Uchila , Fernando Deepika , Rajapakse Senaka 
Published: April 2022

Abstract
Post-chikungunya joint pain (arthritis or arthralgia) is a clinical concern in endemic regions as it may cause a debilitating illness sometimes years after the acute infection. This systematic review analyses evidence from controlled clinical trials regarding the efficacy of pharmacological and non-pharmacological interventions to treat post-chikungunya joint pain. PubMed, EMBASE, Scopus, Cochrane library and Web of Science were searched for eligible studies without any language or time limits, excluding retrospective studies, and prospective observational studies without a control group. Eleven studies met the inclusion criteria. Seven assessed pharmacological interventions and four assessed non-pharmacological interventions (exercise, neuromodulation). The number of participants in each intervention arm varied from 10 to 75 and, given the heterogeneity of interventions, a meta-analysis was not possible. Available evidence does not show any added benefit of chloroquine, hydroxychloroquine, stand-alone methotrexate or ribavirin compared with anti-inflammatory drugs or placebo/no treatment. Non-steroidal anti-inflammatory drugs may reduce pain up to 24 wk of treatment but long-term residual impact after stopping treatment is unassessed. Currently, there is also no high certainty evidence to recommend non-pharmacological methods such as exercise and neuromodulation.
6Film Theory
Authors: Lash Dominic 
Published: April 2022

Abstract
This chapter discusses six notable books published in 2021 (with the exception of Shane Denson’s work, published in late 2020), chosen so as to illustrate both the depth and the breadth of the year’s work in film theory and criticism. It is divided into seven sections: 1. Shane Denson, Discorrelated Images; 2. Adriana Gordjuela, Flashbacks in Film; 3. Paul Coates, Comparative Cinema; 4. Anna Backman Rogers, Still Life; 5. Daniel Morgan, The Lure of the Image; 6. Hoi Lun Law, Ambiguity and Film Criticism; 7. Conclusion.
Osteology and phylogenetic position of the diminutive ‘microsaur’Odonterpeton triangularefrom the Pennsylvanian of Linton, Ohio, and major features of recumbirostran phylogeny
Authors: Mann Arjan , Pardo Jason D , Sues Hans-Dieter 
Published: April 2022

AbstractThe group of Permo-Carboniferous tetrapods known as Recumbirostra have recently been hypothesized to represent the earliest radiation of fossorial reptiles. Therefore, understanding the anatomy and diversity of this clade is essential to understanding the origin and early evolution of amniotes. Here, we redescribe the diminutive ‘microsaur’ Odonterpeton triangulare from the Moscovian-age deposit of Linton, Ohio, revealing new details on the structure of the cranium and palate, including the presence of a conspicuous transverse flange of the pterygoid, which is a feature traditionally associated with early amniotes. Phylogenetic analysis supports the placement of Odonterpeton triangulare within Recumbirostra as sister taxon to the recently described Joermungandr bolti from the slightly older Mazon Creek, Illinois, Lagerstätte. Together, these two diminutive recumbirostrans are placed in an Odonterpetidae clade. Furthermore, we provide a discussion of newly recognized anatomical features in recumbirostrans and discuss major features of recumbirostran phylogeny. We designate a new recumbirostran clade, Chthonosauria (Brachystelechidae + Molgophidae), which is supported by a number of shared derived cranial features.
Biocontrol and Growth Promotion Potential of Combined Application of Trichoderma simmonsii and Aspergillus westerdijkiae Against Apple Tree Dieback Disease
Authors: Ben M'henni Yosra , Salem Ibtissem Ben , Souli Mounira , Tounsi Slim , Debieu Danièle , Fillinger Sabine , Boughalleb-M'hamdi Naima 
Published: April 2022

Our study aimed at selecting new biological control agent (BCA) strains for their inhibitory activities against Pythiaceae species causing apple dieback as new sources to control this important disease of Tunisian apple orchards. We focused on antibiosis as a mode of action of selected isolates obtained from our screening. The fungal isolates Trichoderma simmonsii A2, T. asperellum A3, and Aspergillus westerdijkiae A7 showed the strongest inhibition profiles against the tested Pythiaceae isolates with respect to inhibition rates and activity spectra in in vitro inhibition assays using the isolates or their culture filtrates. In particular, A. westerdijkiae A7 culture filtrate inhibited growth of Pythiaceae isolates by up to 100%. T. simmonsii A2, A. westerdijkiae A7, and one bacterial isolate ( Bacillus sp. strain B2) were tested for their protective effect in planta against dieback disease on apple rootstocks alone or in combination as preventive and curative applications. The results revealed that T. simmonsii A2 exhibited the strongest preventive activity against Pythium undulatum BME and Phytophthora inundata BGA1 in solo application. The combination of different BCAs had contrasting effects on disease control, indicating additive or synergistic effects between two BCAs but negative interactions in the triple combination. Our study also revealed that the three tested BCAs had plant growth-promoting activities on root and shoot parameters, alone or in combination. Altogether, our study provides promising leads for new BCAs. The BCA combination is of particular interest for further studies aiming at the isolation of new molecules with anti-oomycete and/or plant growth-promoting activity. [Formula: see text] Copyright © 2022 The Author(s). This is an open access article distributed under the CC BY-NC-ND 4.0 International license .
Metastatic Melanoma to a Neurofibroma
Authors: Ireland Amanda , Williams Bernadette , Rijhumal Anmol , Mesbah Ardakani Nima 
Published: April 2022

Abstract:
We present an extraordinary case of metastatic cutaneous melanoma to a pre-existing neurofibroma in a 75-year-old man with a history of primary invasive melanoma in an anatomically close vicinity. Histological examination of the metastatic melanoma showed a well-circumscribed intradermal nodule of frankly malignant epithelioid melanocytes without an intraepidermal component, surrounded and sharply demarcated from a diffuse spindle cell proliferation with morphological features of a neurofibroma. The spindle cell component showed bland cytologic features, with no mitotic activity or lymphocytic inflammation and no features of malignancy. By immunohistochemistry, both components expressed S100, while HMB45 positivity and complete loss of p16 were only observed in the epithelioid cells. The morphologically distinct areas were analyzed by fluorescent in situ hybridization, which demonstrated an abnormal profile (gain of RREB1 and homozygous loss of CDKN2A) in the epithelioid nodule; however, no abnormalities were detected in the spindle cell component. Next-generation sequencing showed somatic NRAS and PTEN mutations in the melanoma cells only. The overall molecular findings supported the immunomorphological diagnosis of metastatic melanoma within a neurofibroma over the potential differential diagnosis of melanoma with a neurofibroma-like spindle/desmoplastic component.
Vital Sign Changes During Intravenous Ketamine Infusions for Depression
Authors: Keith Katherine M. , Geller Jamarie , Froehlich Alexis , Arfken Cynthia , Oxley Megan , Mischel Nicholas 
Published: April 2022

Abstract

Purpose/Background
Subanesthetic dosing of intravenous ketamine has shown to be an effective treatment for patients with major depressive disorder. It is unknown whether sympathetic response is related to treatment outcomes. The purpose of this study is to evaluate sympathetic response to ketamine infusions as it relates to treatment outcomes.

Methods/Procedures
This retrospective study examines an outpatient population diagnosed with major depressive disorder or bipolar depression treated with ketamine infusions. Patient characteristics, depressive symptoms measured with the Patient Health Questionnaire (PHQ-9), and vital signs were retrieved by chart review. Patients (n = 145) were categorized as responders (50% reduction in PHQ-9 or less than 10 on final PHQ-9) or nonresponders. Changes in vital signs were recorded during each infusion for the initiation series.

Findings/Results
Ketamine responders (51.7%) showed a significant greater increase in systolic blood pressure response during the first infusion when compared with nonresponders. There was no difference seen in diastolic pressure, heart rate, or rate pressure product. Changes in vital signs for subsequent infusions also did not approach significance.

Implications/Conclusions
Physiologic sensitivity to the effects of ketamine may predict treatment responsiveness. Blood pressure and heart rate did not always increase. Further work should examine possible influences on physiologic responses.
Efficacy and safety of electroacupuncture at auricular concha region in promoting of rehabilitation of ischemic stroke patients with upper limb motor dysfunction
Authors: Liu Yilin , Zhang Liping , Wang Sanrong , Long Lu , Zang Qianwen , Jia Gongwei 
Published: April 2022

Abstract

Introduction:
Ischemic stroke (IS) is the one of the most severe neurological disease, survivors may live with upper limb motor dysfunction (ULMD) resulting in heavy social and economic burden. Nowadays, there are few approaches to promote the rehabilitation of ULMD. Auricular acupuncture (electroacupuncture [EA]) has long been used in the treatment of neurological disorders in China. This treatment has become an attractive treatment option due to its low cost, portability, minimal side effects, and ease of use in clinical and operational environments. However, its efficacy and safety in consciousness recovery remain to be proved.

Methods:
A total of 80 IS patients with single upper limb motor function impairment will be recruited in the trial and randomized into EA or control groups. Patients in the control group will receive routine conventional treatment alone while patients in the EA group will receive EA treatment for 3 consecutive weeks based on routine conventional treatment. Baseline evaluation was carried out on day of enrollment, post-treatment evaluation was carried out 14 and 21 days after enrollment, and the 2 groups were follow-ups in 3 and 6 months after the end of the trial. The efficacy will be assessed with the changes in the upper limb Fugl–Meyer assessment, Wolf motor function test, action research arm test, active range of motion, and Barthel index. The safety of EA will be estimated by monitoring the incidence of adverse events and changes in vital signs during the study period. Analysis of feasibility will be descriptive and the change in outcome measures between groups will be analyzed using an independent sample t test.

Discussion:
This study tried to narrow the evidence gap on the efficacy of EA at the auricular on the recovery of ULMD in patients with IS. The results of this trial will provide strong evidence for the efficacy and safety of EA of auricular concha region stimulation for IS patients.

Trial registration: This trial has been registered at the Chinese Clinical Trial Registry, numbered ChiCTR2100049678.
The right apical tracheal bronchus with bronchial leiomyoma
Authors: Zhang Yu , Ma Haitao 
Published: April 2022

Abstract

Rationale:
Tracheal bronchus is an aberrant bronchus that arises directly from the carina of the trachea. It was rare, with only 0.1% to 2% on the right and 0.3% to 1% on the left side of the lateral wall. Tracheal bronchus is usually asymptomatic and can be accidentally detected during bronchoscopy or computed tomography (CT).

Patient concerns:
A 62-year-old woman presented with recurrent cough and sputum for more than 1 month.

Diagnosis:
Bronchoscopy and three-dimensional-CT confirmed that the bronchial leiomyoma blocked the opening of the right apical segmental tracheal bronchus.

Interventions:
After 2 bronchoscopy treatments, the patient still complained of. cough and sputum. Finally, the patient underwent thoracotomy for a right apical segmentectomy and tracheoplasty.

Outcomes:
The patient was safely discharged and no longer experienced cough. or sputum.

Lessons:
Surgery can reliably remove bronchial leiomyomas. When crossing. the tracheal bronchus, it is important to be cautious about the pulmonary. In such situations, bronchoscopy and three-dimensional-CT are beneficial for surgery.
Extended-release tofacitinib for refractory Behçet disease
Authors: Wang Chrong-Reen , Wong Tak-Wah , Hsu Sheng-Min 
Published: April 2022

Abstract

Rationale:
Although single-cytokine inhibitors can be considered in treating severe or refractory Behçet disease (BD), these biologic agents are associated with potential therapeutic failure due to the multi-cytokine pathogenesis involving Th1- and Th17-type cytokines with activated Janus kinase/signal transducer and activator of transcription signaling pathways. Notably, there is an increasing trend toward the use of small-molecule targeted drug tofacitinib (TOF), a pan-Janus kinase inhibitor, with immediate-release formulations for treating patients with severe or refractory systemic vasculitis involving different vessel sizes. Despite no reported efficacy of extended-release formulations in refractory BD yet, such a dosage form has pharmacokinetic parameters that are comparable to those of conventional immediate-release formulations.

Patient concerns and diagnosis:
We report the case of a 27-year-old local woman with recurrent manifestations of arthritis, orogential ulcerations, papulopustular lesions, and anterior uveitis. She was diagnosed with BD for more than 3 years, and received long-term corticosteroids plus immunosuppressants therapy with the complication of opportunistic candidiasis infection.

Interventions and outcomes:
Under extended-release TOF 11 mg once-daily therapy, the patient achieved disease remission while sparing the use of corticosteroids during follow-up.

Lessons:
Our clinical observations implicate the oral convenience and therapeutic efficacy of extended-release TOF formulations in controlling the disease activity of BD.
The incidence and characteristics of chronic pain and fatigue after 12 months later admitting with COVID-19; The Post- COVID 19 syndrome
Authors: Janbazi Lobaneh , Kazemian Alireza , Mansouri Kourosh , Madani Seyed Pezhman , Yousefi Naseh , Vahedifard Farzan , Raissi Gholamreza 
Published: April 2022

Abstract

Introduction
This study aimed to evaluate chronic pain and fatigue in patients 12 months after hospitalization for Covid-19.

Methods
We studied the COVID-19 patients discharged from Hospital, March 10 and April 20, 2020.

Results
A total of 157 patients were included in this study. Forty-three patients (27.4%) complained of chronic fatigue and muscle weakness in the last six months. The visual analog fatigue scale (VAFS) score of 3.84 ± 1.48 was obtained. Forty patients (25.5%) were suspected of Chronic Fatigue Syndrome (CFS).
Twenty-four patients (15.3%) had severe chronic pain or exacerbation of previous chronic pain, most of which were reported in the lower back (70.8%) and lower extremities (66.7%). Pain intensity had a mean score of 2.33 ± 0.87 and was mainly described as "muscle cramps," "persistent dull pain," and "boring and numbing." In women, chronic pain and fatigue, extended hospital stays, ICU admission, and depressed mood were common than in men.
For these pain and fatigue, 37% used nonsteroidal anti-inflammatory drugs, and 16.3% used antidepressants. Only one person had applied for physiotherapy, and none of the patients had received psychotherapy.

Conclusion
Fatigue and chronic pain in patients recovering from COVID-19 are common complications, even after 12 months of illness.