bluuebunny/crossref_metadata_2025_split huggingface dataset:
Postendovascular Aneurysmal Repair Increase in Local Energy Loss for Fusiform Abdominal Aortic Aneurysm: Assessments With 4D flow MRI
Authors: Horiguchi Ryota , Takehara Yasuo , Sugiyama Masataka , Hyodo Ryota , Komada Tomohiro , Matsushima Masaya , Naganawa Shinji , Mizuno Takashi , Sakurai Yasuo , Sugimoto Masayuki , Banno Hiroshi , Komori Kimihiro , Itatani Keiichi 
Published: July 2022

BackgroundAlthough endovascular aneurysmal repair (EVAR) is a preferred treatment for abdominal aortic aneurysm (AAA) owing to its low invasiveness, its impact on the local hemodynamics has not been fully assessed.PurposeTo elucidate how EVAR affects the local hemodynamics in terms of energy loss (EL).Study TypeProspective single‐arm study.Field Strength/SequenceA 3.0 T/4D flow MRI using a phase‐contrast three‐dimensional cine‐gradient‐echo sequence.PopulationA total of 13 consecutive patients (median [interquartile range] age: 77.0 [73.0, 78.8] years, 11 male) scheduled for EVAR as an initial treatment for fusiform AAA.Assessment4D flow MRI covering the abdominal aorta and bilateral common iliac arteries and the corresponding stent‐graft (SG) lumen was performed before and after EVAR. Plasma brain natriuretic peptide (BNP) was measured within 1 week before and 1 month after EVAR. The hemodynamic data, including mean velocity and the local EL, were compared pre‐/post‐EVAR. EL was correlated with AAA neck angle and with BNP. Patients were subdivided into deformed (N = 5) and undeformed SG subgroups (N = 8) and pre‐/post‐EVAR BNP compared in each.StatisticsParametric or nonparametric methods. Spearman's rank correlation coefficients (r). The interobserver/intraobserver variabilities with Bland–Altman plots. A P value < 0.05 is considered significant.ResultsThe mean velocity (cm/sec) at the AAA was five times greater after EVAR: 4.79 ± 0.32 vs. 0.91 ± 0.02. The total EL (mW) increased by 1.7 times after EVAR: 0.487 (0.420, 0.706) vs. 0.292 (0.192, 0.420). The total EL was proportional to the AAA neck angle pre‐EVAR (r = 0.691) and post‐EVAR (r = 0.718). BNP (pg/mL) was proportional to the total EL post‐EVAR (r = 0.773). In the deformed SG group, EL (0.349 [0.261, 0.416]) increased 2.4‐fold to 0.848 (0.597, 1.13), and the BNP 90.3 (53.6, 105) to 100 (67.2, 123) post‐EVAR.ConclusionThe local EL showed a 1.7‐fold increase after EVAR. The larger increase in the EL in the deformed SG group might be a potential concern for frail patients.Evidence Level1Technical EfficacyStage 2
Microstructural Alterations in Projection and Association Fibers in Neonatal Hypoxia–Ischemia
Authors: Cao Zuozhen , Lin Huijia , Gao Fusheng , Shen Xiaoxia , Zhang Hongxi , Zhang Jiangyang , Du Lizhong , Lai Can , Ma Xiaolu , Wu Dan 
Published: July 2022

BackgroundDiffusion MRI (dMRI) is known to be sensitive to hypoxic–ischemic encephalopathy (HIE). However, existing dMRI studies used simple diffusion tensor metrics and focused only on a few selected cerebral regions, which cannot provide a comprehensive picture of microstructural injury.PurposeTo systematically characterize the microstructural alterations in mild, moderate, and severe HIE neonates compared to healthy neonates with advanced dMRI using region of interest (ROI), tract, and fixel‐based analyses.Study TypeProspective.PopulationA total of 42 neonates (24 males and 18 females).Field Strength/Sequence3‐T, diffusion‐weighted echo‐planar imaging.AssessmentFractional anisotropy (FA), mean diffusivity (MD), radial diffusivity (RD), axial diffusivity (AD), fiber density (FD), fiber cross‐section (FC), and fiber density and cross‐section (FDC) were calculated in 40 ROIs and 6 tracts. Fixel‐based analysis was performed to assess group differences in individual fiber components within a voxel (fixel).Statistical TestsOne‐way analysis of covariance (ANCOVA) to compare dMRI metrics among severe/moderate/mild HIE and control groups and general linear model for fixel‐wise group differences (age, sex, and body weight as covariates). Adjusted P value < 0.05 was considered statistically significant.ResultsFor severe HIE, ROI‐based analysis revealed widespread regions, including the deep nuclei and white matter with reduced FA, while in moderate injury, only FC was decreased around the posterior watershed zones. Tract‐based analysis demonstrated significantly reduced FA, FD, and FC in the right inferior fronto‐occipital fasciculus (IFOF), right inferior longitudinal fasciculus (ILF), and splenium of corpus callosum (SCC) in moderate HIE, and in right IFOF and left anterior thalamic radiation (ATR) in mild HIE. Correspondingly, we found altered fixels in the right middle‐posterior IFOF and ILF, and in the central‐to‐right part of SCC in moderate HIE.Data ConclusionFor severe HIE, extensive microstructural injury was identified. For moderate–mild HIE, association fiber injury in posterior watershed area with a rightward lateralization was found.Evidence Level1Technical EfficacyStage 3
Research on apoptotic mechanism and related pathways involved in postmortem grass carp (Ctenopharyngodon idellus) muscle
Authors: Tie Huaimao , Yu Dawei , Jiang Qixing , Yang Fang , Xu Yanshun , Xia Wenshui 
Published: July 2022

AbstractBACKGROUNDApoptosis activation is an essential research to reveal the triggering mechanism of flesh quality deterioration. This study was aimed at explaining apoptotic mechanism of postmortem fish in terms of caspases activation, cytochrome c (cyt‐c) release, B‐cell lymphoma 2 (Bcl‐2) and Bcl2‐associated X (Bax) protein levels, transcriptional levels of its molecules, and apoptosis‐inducing factor (AIF) translocation at 4 °C for 5 days.RESULTSActivation of caspase‐9, caspase‐8, caspase‐3 and the release of mitochondrial cyt‐c were observed during storage. The decreased Bcl‐2 protein levels, increased Bax protein expressions and Bax/Bcl‐2 ratio were major steps for inducing apoptosis. Collectively, transcriptional regulation of Fas ligand (FasL), apoptotic protease activating factor‐1 (Apaf‐1), inhibitors of apoptosis proteins (IAPs), myeloid cell leukemia‐1 (Mcl‐1), c‐Jun N‐terminal kinase (JNK) and p38 mitogen‐activated protein kinase (MAPK) indicated that extrinsic apoptotic pathways (FasL/caspase‐8/caspase‐3) and intrinsic pathway [(JNK and p38 MAPK)/(Bcl‐2, Bax and Mcl‐1)/cyt‐c/Apaf‐1/caspase‐9/caspase‐3] were involved in apoptotic process. Mitochondrial AIF translocation to nuclear indicated that AIF mediated caspase‐independent pathway.CONCLUSIONTherefore, transcriptional and translational alterations of multiple signaling molecules acted important roles in regulating apoptosis activation in postmortem process. © 2022 Society of Chemical Industry.
Novel mutations of PMFBP1 in a man with acephalic spermatozoa defects
Authors: Nie Hua , Tang Yunge , Zhang Xiaoyu , Tan Yuqiu , Qin Weibing 
Published: July 2022

AbstractBackgroundAcephalic spermatozoa (AS) is a serious but rare reproductive genetic disorder that causes infertility in men. To date, only a few genes associated with AS defects have been identified, including the polyamine modulated factor 1 binding protein 1 (PMFBP1) gene. Consistent with this, PMFBP1 localizes to the head–neck connection, which bridges the implantation fossa and basal body.MethodsA male patient was diagnosed as having an AS defect. Blood samples from all family members and a sample of the patient's semen were collected to determine the genetic causes of his infertility.ResultsCompound heterozygote mutation in the PMFBP1 gene, which is associated with AS defects in the present case: two loss‐of‐function mutations, with one a nonsense mutation c.361C > T p.Gln121Ter, and another a splice donor mutation c.414 + 1G > T. The current study, together with previous studies, suggests that the nonsense mutation is responsible for a truncated PMFBP1 protein during its formation; a splice donor mutation c.414 + 1G > T might lead to new open reading frames, from which the dysfunction of an abnormal PMFBP1 protein might be predicted. Additionally, the expression of outer dense fiber 1 (ODF1) and ODF2 proteins has been experimentally shown to be regulated by the truncated PMFBP1 protein.ConclusionWe herein present a case with AS defects associated with heterozygote mutations of PMFBP1, which have been shown to be rare and pathogenic; the association with an AS defect is a monogenic disorder with a recessive inherited pattern in the patient's family.
Joint segmentation of retinal layers and macular edema in optical coherence tomography scans based on RLMENet
Authors: Wu Jun , Liu Shuang , Xiao Zhitao , Zhang Fang , Geng Lei 
Published: July 2022

AbstractPurposeThe segmentation of retinal layers and fluid lesions on retinal optical coherence tomography (OCT) images is an important component of screening and diagnosing retinopathy in clinical ophthalmic treatment. We designed a novel network for accurate segmentation of the seven tissue layers of the retina and lesion areas of diabetic macular edema (DME), which can assist doctors to quantitatively analyze the disease.MethodsIn this article, we propose the Retinal Layer Macular Edema Network (RLMENet) model to achieve end‐to‐end joint segmentation of retinal layers and fluids. The network employs dense multi‐scale attention to enhance the extraction of retinal layer and fluid detail information and achieve efficient long‐range modeling, which improves the receptive field and obtains multi‐scale features. As the more complex decoder part is designed, which integrates more low‐level feature information on the decoder side, more features are extracted to gradually restore the resolution of the feature map and improve the segmentation accuracy.ResultsWe used part of the OCT2017 dataset to train and verify the model to divide the data into a training set, validation set, and test set and set it to a 7:2:1 ratio. We evaluated our method on the ISIC2017 dataset. Experimental results showed that the RLMENet model designed in this work can accurately segment seven retinal tissue layers and DME lesions on the retinal OCT dataset. Finally, the MIoU value in the test set reached 86.55%. The model can be extended to other medical image segmentation datasets to achieve better segmentation performance.ConclusionsThe proposed method was superior to the existing segmentation methods, achieved a more refined segmentation effect, and provided an auxiliary analysis tool for clinical diagnosis and treatment.
Directional and inter‐acquisition variability in diffusion‐weighted imaging and editing for restricted diffusion
Authors: Gundogdu Batuhan , Pittman Jay M. , Chatterjee Aritrick , Szasz Teodora , Lee Grace , Giurcanu Mihai , Medved Milica , Engelmann Roger , Guo Xiaodong , Yousuf Ambereen , Antic Tatjana , Devaraj Ajit , Fan Xiaobing , Oto Aytekin , Karczmar Gregory S. 
Published: July 2022

PurposeTo evaluate and quantify inter‐directional and inter‐acquisition variation in diffusion‐weighted imaging (DWI) and emphasize signals that report restricted diffusion to enhance cancer conspicuity, while reducing the effects of local microscopic motion and magnetic field fluctuations.MethodsTen patients with biopsy‐proven prostate cancer were studied under an Institutional Review Board‐approved protocol. Individual acquisitions of DWI signal intensities were reconstructed to calculate inter‐acquisition distributions and their statistics, which were compared for healthy versus cancer tissue. A method was proposed to detect and filter the acquisitions affected by motion‐induced signal loss. First, signals that reflect restricted diffusion were separated from the acquisitions that suffer from signal loss, likely due to microscopic motion, by imposing a cutoff value. Furthermore, corrected apparent diffusion coefficient maps were calculated by employing a weighted sum of the multiple acquisitions, instead of conventional averaging. These weights were calculated by applying a soft‐max function to the set of acquisitions per‐voxel, making the analysis immune to acquisitions with significant signal loss, even if the number of such acquisitions is high.ResultsInter‐acquisition variation is much larger than the Rician noise variance, local spatial variations, and the estimates of diffusion anisotropy based on the current data, as well as the published values of anisotropy. The proposed method increases the contrast for cancers and yields a sensitivity of with a false positive rate of .ConclusionMotion‐induced signal loss makes conventional signal‐averaging suboptimal and can obscure signals from areas with restricted diffusion. Filtering or weighting individual acquisitions prior to image analysis can overcome this problem.
Comparison of the efficacy and safety of quetiapine and lithium for bipolar depression: A systematic review and meta‐analysis of randomized controlled trials
Authors: Ogasawara Masaya , Takeshima Masahiro , Esaki Yuichi , Kaneko Yoshiyuki , Utsumi Tomohiro , Aoki Yumi , Watanabe Norio , Suzuki Masahiro , Takaesu Yoshikazu 
Published: July 2022

AbstractAimPharmacological treatments recommended for bipolar depression are inconsistent across guidelines. We compared the efficacy and safety of antipsychotics and mood stabilizers for bipolar depression.MethodsA systemic review and meta‐analysis of randomized controlled trials comparing antipsychotics and mood stabilizers for bipolar depression was conducted based on a literature search of major electronic databases.ResultsThree studies comparing quetiapine with lithium were identified and analyzed; no other antipsychotic‐mood stabilizer combinations were found. The meta‐analysis revealed no significant differences between quetiapine and lithium for the following outcomes: (1) remission from depressive episodes (risk ratio [RR]: 1.80, 95% CI: 0.51‐6.40, P = 0.36), (2) changes in depressive symptom (standardized mean difference: −0.22, 95% CI: −0.52‐0.08, P = 0.15), (3) changes in social function (standardized mean difference: −0.00, 95% CI: −0.19‐0.18, P = 0.98), (4) suicide‐related events (odds ratio [OR]: 2.35, 95% CI: 0.40‐13.65, P = 0.34), (5) severe adverse events (OR: 1.63, 95% CI: 0.51‐5.20, P = 0.41), (6) dropouts due to adverse events (RR: 1.19, 95% CI: 0.76‐1.87, P = 0.45, 7) dropout for any reasons (RR: 0.95, 95% CI: 0.74‐1.22, P = 0.70).ConclusionAlthough this study found no differences in the efficacy and safety of quetiapine and lithium for bipolar depression, a comprehensive comparison of antipsychotics and mood stabilizers was not performed. Further studies are needed to clarify which of these, not just quetiapine and lithium, is more useful for bipolar depression.
The dark side of nature experience: Typology, dynamics and implications of negative sensory interactions with nature
Authors: Soga Masashi , Gaston Kevin J. 
Published: July 2022

Abstract

The human health benefits of direct sensory interactions with nature (hereafter direct human–nature interactions) are increasingly recognised. However, these interactions can also have various negative health and well‐being impacts on people, some of which may be severe. Compared to positive ones, there has been relatively little investigation of such negative direct human–nature interactions beyond the medical literature, and what has been done is widely scattered across disciplines.

Here, we provide an overview of the typology, characteristics and dynamics of negative direct sensory interactions with nature and suggest management implications and future research directions.

We highlight the breadth of forms that negative direct human–nature interactions occur, and evidence that the incidences of some have recently grown rapidly in many parts of the world.

Our review also suggests that more intense negative direct human–nature interactions can sometimes occur simultaneously or sequentially with more positive ones, and there may be trade‐offs between the two.

Such serious implications highlight the importance of focusing research and public policy on improving the understanding of negative direct human–nature interactions, taking a more balanced view of the benefits and costs of nature experiences, and developing appropriate mitigation strategies.

Read the free Plain Language Summary for this article on the Journal blog.
One‐pot sequence‐selective synthesis of polylactone‐containing block terpolymers based on renewable terpenoid‐derived monomer and a simple organocatalyst
Authors: Xie Hongyan , Feng Jiabing , Yang Xiaoxia , Zhao Yan , Song Pingan , Wang Hao , Xu Zhiguang 
Published: July 2022

AbstractIn this work, we report the synthesis and polymerization performances of terpenoid‐derived camphoric anhydride (CA). Utilizing simple organo‐base tBuP2 as the catalyst, CA can polymerize with various epoxides by efficient and controlled ring‐opening alternating copolymerization (ROAC) to afford perfectly alternating poly(CA‐alt‐epoxide). Kinetic study shows that the polymerization proceeds following zero‐order dependence on the concentration of CA. The self‐switchable terpolymerization from the mixture of CA, propylene oxide (PO) and ε‐caprolactone (CL) is conducted under the catalysis of tBuP2. First, ROAC of CA and PO is carried out exclusively with benzyl alcohol as initiator. Then, block copolymer (BCP) poly(CA‐alt‐PO)‐b‐PCL is obtained via the sequential polymerizations after the complete consumption of CA. The followed ring‐opening polymerization (ROP) of CL is initiated by the terminal hydroxyl of the ROAC‐resulted poly(CA‐alt‐PO) polyester without external stimulus. During the process, the excess PO compound remains intact. The one‐pot synthesis displays distinct living nature and perfect chemoselectivity. The as‐prepared terpenoid‐derived alternating and BCP's exhibit elevated thermal properties.
Dynamic Tuning and Swapping of Electric and Magnetic Dipolar Mie Resonances in High Index Dielectric Particles Dispersed in an Anisotropic Medium
Authors: Bhardwaj Amit , Puthoor Navas Meleth , Nair Geetha G. 
Published: July 2022

AbstractHigh refractive index (n > 2.5) dielectric particles support strong electric and magnetic Mie resonances in the visible region enabling optical properties such as directional scattering, anapole modes, and Fano resonances with applications in nanophotonics. Selenium particles, which possess a high refractive index at optical frequencies, have been synthesized using a controlled approach involving a moderate reduction of selenious acid to obtain particles of the desired size. The extinction spectra from UV–vis spectroscopy in conjunction with theoretical simulations confirm the presence of highly size‐dependent dipole and quadrupole Mie resonances in the visible region. Dynamic tuning of magnetic and electric Mie resonances and swapping of electric and magnetic dipoles are observed in a colloidal dispersion of 250 nm‐sized selenium particles in a nematic liquid crystal due to the anisotropic nature of the latter. Theoretical simulations reveal the presence of unidirectional scattering and photonic‐nanojet formation, attributed to generalized Kerker's effects in nanophotonics and meta‐optics, due to the swapping phenomena leading to the superposition of dipole and quadrupole resonances. The manipulation of Mie resonances in the liquid crystal based colloidal metamaterial has the potential for large‐scale and cost‐effective nanophotonic device applications.
Optimization of prostate cancer patient lymph node staging via the integration of neutrophil–lymphocyte ratios, platelet–lymphocyte ratios, and 68Ga‐PSMA‐PET‐derived SUVmax values
Authors: Wang Yinzhao , Tang Yongxiang , Gao Xiaomei , Gan Yu , Hu Shuo , Chen Min‐Feng , Cai Yi 
Published: July 2022

AbstractBackgroundAt present, standardized parameters for quantitatively evaluating 68Ga‐PSMA‐PET/CT outcomes when diagnosing lymph node metastasis in prostate cancer patients are lacking. Inflammatory hematological biomarkers offer value as robust predictors of certain cancer‐related outcomes. The present study was thus developed to explore approaches to improving the utility of 68Ga‐PSMA‐PET/CT for diagnosing lymph node metastasis through the combined evaluation of inflammatory hematological markers in prostate cancer patients.MethodsPretreatment patient details including age, initial TPSA levels, hematological findings, biopsy pathology results (Gleason score and ISUP grouping), radical pathology results, and imaging details were collected. Optimal cutoff values for each predictor then being determined based upon Youden's index, with univariate and multivariate analyses were then used to identify independent predictors of lymph node metastasis and used to construct a nomogram.ResultIndependent predictors of lymph node metastasis in this patient cohort included SUVmax (odds ratio [OR]: 30.549, 95% confidence interval [CI]: 10.855–85.973, p < 0.001), neutrophil‐lymphocyte ratio (OR:8.221, 95%CI: 1.335–50.614, p = 0.023), platelet‐lymphocyte ratio (OR:8.221, 95% CI: 1.335–50.614, p = 0.023), initial TPSA (OR:2.761, 95% CI: 1.132–6.733, p = 0.026), and clinical T‐stage (T3 vs. T2, OR:11.332, 95% CI:3.929–32.681, p < 0.001; T4 vs. T2, OR:9.101, 95% CI:1.962–42.213, p = 0.005), with corresponding optimal cutoff values of 2.3 (area under the curve [AUC]: 0.873, sensitivity: 0.736, specificity: 0.902), 1.72 (AUC: 0.558, sensitivity: 0.529, specificity: 0.643), 83.305 (AUC: 0.651, sensitivity: 0.299, specificity: 0.979), and 21.875 (AUC: 0.672, sensitivity: 0.736, specificity: 0.601). Subsequent nomogram construction was associated with good predictive ability, with a C‐index of 0.887(95% CI: 0.793–0.981) and an AUC of 0.924 (95% CI: 0.882–0.965).ConclusionSUVmax, the neutrophil–lymphocyte ratio, the platelet–lymphocyte ratio, initial TPSA, and clinical T‐stage represent valuable independent predictors of lymph node metastasis in prostate cancer patients, offering an opportunity to further optimize lymph node staging for these patients.
Monolayer Plasmonic Nanoframes as Large‐Area, Broadband Metasurface Absorbers
Authors: Li Yuanwei , Tanriover Ibrahim , Zhou Wenjie , Hadibrata Wisnu , Dereshgi Sina Abedini , Samanta Devleena , Aydin Koray , Mirkin Chad A. 
Published: July 2022

AbstractBroadband absorbers are useful ultraviolet protection, energy harvesting, sensing, and thermal imaging. The thinner these structures are, the more device‐relevant they become. However, it is difficult to synthesize ultrathin absorbers in a scalable and straightforward manner. A general and straightforward synthetic strategy for preparing ultrathin, broadband metasurface absorbers that do not rely on cumbersome lithographic steps is reported. These materials are prepared through the surface‐assembly of plasmonic octahedral nanoframes (NFs) into large‐area ordered monolayers via drop‐casting with subsequent air‐drying at room temperature. This strategy is used to produce three types of ultrathin broadband absorbers with thicknesses of ≈200 nm and different lattice symmetries (loose hexagonal, twisted hexagonal, dense hexagonal), all of which exhibit efficient light absorption (≈90%) across wavelengths ranging from 400–800 nm. Their broadband absorption is attributed to the hollow morphologies of the NFs, the incorporation of a high‐loss material (i.e., Pt), and the strong field enhancement resulting from surface assembly. The broadband absorption is found to be polarization‐independent and maintained for a wide range of incidence angles (±45°). The ability to design and fabricate broadband metasurface absorbers using this high‐throughput surface‐based assembly strategy is a significant step toward the large‐scale, rapid manufacturing of nanophotonic structures and devices.