bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of L1CAM, SOX11, and chromogranin expression in pancreatic tumors: an immunohistochemical study
Authors: Bassyoni Omneya Y. , Abd-Rabh Rasha M. , Swilem Mohamed R. 
Published: February 2025

Introduction
Pancreatic duct adenocarcinoma (PDAC) is the 11th most common type of cancer and its incidence and death rates are steadily rising. In contrast to PDAC and pancreatic neuroendocrine tumors (PNETs), solid pseudopapillary neoplasm (SPN) is a low-grade malignant pancreatic tumor that exhibits distinct characteristics in terms of tumor aggressiveness, treatment, and prognosis.

Aim
To investigate the expression of L1CAM, SOX11, and chromogranin in PDAC, SPN, and PNETs and to show their diagnostic and prognostic significance.

Materials and methods
Retrospective Immunohistochemical staining of L1CAM, Sox11, and chromogranin was performed on selected 54 cases of pancreatic tumors.

Results
L1CAM was highly expressed in 73.3% of PDAC cases compared with 81.8% of SPN and 100% of PNET cases. SOX11 was positive in 90.9% of SPN, but negative in 100% of PDAC and 93.3% of PNETS cases. Chromogranin was positive in 76.9% of PNETS. SOX11 is a highly sensitive (100%) marker for discriminating between SPN and PDAC. Both SOX11 and chromogranin are highly specific (100%) and sensitive (90.9%) markers in differentiating SPN from PNET. L1CAM was significantly positively correlated with tumor grade (P=0.02), T stage (P=0.02), lymph node metastasis (P=0.002), LVI (P=0.000), and distant metastasis (P=0.046) of PDAC studied cases.

Conclusion
SOX11 could be considered a highly sensitive marker for differentiating SPN from PDAC and PNETs. The combined expression of L1CAM, SOX11, and chromogranin may play a valuable role in solving this diagnostic challenge. L1CAM might have prognostic significance for PDAC and, hence, target therapy.
Expression analysis and potential validity of PRMT3, IGF2BP1 in adrenocortical carcinoma and their correlation with FOXM1
Authors: Allah Marwa S.A. , Ahmed Mona , El Kariem Heba Abd , ElSayed Amira 
Published: February 2025

Background
PRMT3 and IGF2BP1 overexpression has been detected in several malignancies and has been recognized by their oncogenic role. No studies have handled the expression of PRMT3 and IGF2BP1 in adrenocortical carcinoma (ACC) and their association with outcome. This work aimed at exploring the significance of PRMT3 and IGF2BP1 expression in ACC and their correlation with FOXM1 expression.

Patients and methods
Immunohistochemistry accessed quantitative expression of PRMT3, IGF2BP1, and FOXM1 proteins in 60 cases of ACC and 20 cases of adrenocortical adenoma. IGF2BP1 mRNA and PRMT3 mRNA were also evaluated using a quantitative real-time PCR.

Results
PRMT3, IGF2BP1, and FOXM1 expression were statistically highly significant in ACC compared to adrenocortical adenoma (P<0.001). PRMT3 high expression showed a significant correlation with ENSAT stage (P<0.001), distant metastasis (P<0.001), recurrence (P<0.001), Weiss score, and Ki-67 index (P<0.05). IGF2BP1 high expression showed a significant correlation with ENSAT stage (P<0.001), Weiss score (P<0.001), recurrence (P<0.001), distant metastasis (P<0.05), and Ki-67 index (P<0.05). PRMT3 and IGF2BP1 showed a high significant correlation with FOXM1 (P<0.001).

Conclusion
PRMT3, IGF2BP1, and FOXM1 are upregulated in ACC. PRMT3, IGF2BP1, and FOXM1 contribute to aggressive phenotypes of ACC and might serve as poor potential prognostic factors.
Estimating the average normal thickening of the glomerular basement Membrane in a subset of Egyptian population: an electron microscopic study
Authors: Tawfik Sarah H. , Hassan Tamer A.T. 
Published: February 2025

Aim
The presented study is an electron microscopic morphometric work that aimed at reporting a normal range and average (arithmetic mean) of the glomerular basement membrane (GBM) thickness in the Egyptian population. This is important as a baseline for diagnosing renal disorders that are related to abnormalities in the GBM thickness such as Thin Basement Membrane Disease and Alport Syndrome.

Patients and methods
This study included 40 patients; 20 adults and 20 children (10 males and 10 females in each group). Patients were diagnosed with Minimal Change Disease or Acute Tubular Injury based on their routine histopathologic examination. Hematuria and/or diabetes mellitus were the exclusion criteria in our study.

Results and conclusion
The mean of the GBM thickness in adult males was 362.6093 nm (SD +/–31.13). That of adult females was 349.85 nm (SD +/–21.65). While for male children was 255.68 nm (SD +/–35.36). And female children reported 234.57 nm (SD +/–55.03). Rare segments of the GBM showed thicker or thinner measurements than the reported average were present in almost all patients in the study. Similarly, rare segments of GBM wrinkling could be encountered. However, these rare segments could be considered as a normal findings.
Construction of In vitro Dose-response Curve for Human Peripheral Blood Exposed to High-energy Clinical 6 MV X-rays
Authors: Radhakrishna Vishakh , Nalilu Suchetha Kumari , Gnanasekaran Tamizh Selvan 
Published: February 2025

ABSTRACT

Introduction:
High-energy LINAC X-rays are used instead of the traditional modality (γ-rays) in cancer radiotherapy. Health professionals may be exposed to these high-energy X-rays owing to mishandling or mechanical failure, and using a low-energy X-rays calibration curve may not yield a meaningful dose estimate. This study aimed to obtain a dose calibration curve by scoring dicentric chromosomes (DC) in peripheral blood cells exposed to a high-energy clinical 6 MV X-ray in vitro.

Materials and Methods:
The peripheral blood samples from healthy donors (n = 2) were irradiated with 6 MV energy (5.78 Gy/min) of X-ray and induced biological damage was quantified as DC formation, as it is considered the gold standard biodosimetry.

Results:
Compared to the unexposed sample, the observed DC frequency in the X-irradiated samples reveals a significant (P < 0.0001) dose-dependent increase. There is no significant (P > 0.05) difference in DC analysis for intrascorer variances. The dose-response curve was fitted with a linear-quadratic fit.

Conclusion:
The established dose-response curve generated (c = 0.0007 ± 0.001, αD = 0.035 ± 0.013, βD2 = 0.045 ± 0.005) for peripheral blood subjected to high energy clinical 6 MV X-irradiation could be used for biological dosimetry readily.
Study of Anti-mullerian Hormone as a Diagnostic Criteria for Polycystic Ovarian Syndrome
Authors: Pandit Abhimanyu , Bhardwaj Bikram , Nandy Souvik , Chakravarty Rony 
Published: February 2025

ABSTRACT

Background:
PCOS is most common endocrine disorders among women of reproductive age group. This syndrome has varied manifestations affecting the females of all age groups. Rotterdam criteria are the most used for the diagnosis of PCOS. AMH is a newer marker which is secreted much more by the polycystic ovaries compared to normal ovaries and is not affected by day of menstrual cycle and even use of OCPs. Due to persistent controversies regarding diagnosis of PCOS due to its complex presentation and to evaluate ovarian morphology, AMH can be used as a new quantitative and biologic marker for PCOS.

Methods:
This was a case–control study performed on women attending Gynaecology OPD at a tertiary care hospital. The study consisted of 100 women with PCOS, diagnosed using Rotterdam criteria and 173 women as controls. Clinical profile, clinical examination, BMI, blood investigations like FSH, LH, TSH, prolactin and AMH levels were assessed. Sonography of the pelvis to see the ovarian morphology was done for all women.

Results:
AMH levels in PCOS cases were on average 8.16 ng/ml, which was significantly higher than controls’ levels of 3.05 ng/ml (p = 0.001). AMH produced sensitivity of 83% when employed as a supplement to the current Rotterdam criteria as the fourth criterion. However, when AMH was used in place of PCOM in the Rotterdam criterion, AMH produced a sensitivity of 89%.

Conclusion:
To conclude AMH levels were considerably greater in PCOS. AMH values offer good diagnostic potential when used in conjunction with the current Rotterdam criteria for the diagnosis of PCOS
Comparison of Trunk Kinematics, Fear of Falling, and Physical Performance Between Fallers and Non-fallers Older Adults: A Cross-sectional Study
Authors: D’souza Jude John , Velani Kruti , Gardas Shailesh 
Published: February 2025

ABSTRACT

Background:
One of the primary causes of falls in the elderly population is poor physical performance, along with impaired balance. Since the quality of bodily movements affects overall human functioning, highlighting the importance of analyzing kinematic parameters when planning rehabilitation programs, several outcome measures, such as the Fall Efficacy Scale – International (FES-I), Timed-Up and Go (TUG), and Short Physical Performance Battery (SPPB), have been employed in clinical settings to screen for falls in the geriatric population, but there is a paucity of literature exploring the kinematic analysis of the trunk to assess fall risk.

Aim of the Study:
The present study aimed to assess the kinematics of trunk flexion-extension during a single sit-to-stand test using smartphone-based sensors, assess fear of falls using fall-related outcome measures, and compare these parameters between faller and non-faller older adults aged 60 years and above.

Methods and Materials:
In the present study, 30 older adults were grouped as non-fallers (n = 15) and fallers (n = 15), and both groups were assessed for fear of falling and the risk of falling using the FES-I, TUG, and SPPB. The kinematics of trunk flexion and extension were assessed by a smartphone-based accelerometer and gyroscope using the Sensor Kinetic Pro app during a 10-m walk test.

Settings and Design:
The present study used a cross-sectional design and was conducted in an institute-based rehabilitation center, and approval from the Institutional Ethical Committee (IEC) was obtained before the commencement of the study.

Statistical Analysis:
Data analysis was performed using Statistical Package for the Social Sciences (SPSS) version 24 for Windows (IBM Corp., Armonk, NY, USA). The data were tested for normal distribution using the Shapiro-Wilk test. The Mann-Whitney U test was employed for all variables, and an independent t-test was used for TUG. Statistical significance was set at P < 0.05.

Results:
There was a significant difference in FES-I (P = 0.002), TUG (P = 0.002), and SPPB (P = 0.019) between fallers and non-fallers.

Conclusion:
The present study concludes that the comparison of fear of falling using outcome measures such as FES-I, TUG, and SPPB between fallers and non-fallers among older adults aged 60 years and above is useful in assessing fear of falling and predicting future risk of falls among older adults.
The Effect of A Digital Financial Literacy on Financial Performance of Msmes: A Quasi-Experimental Study Supporting SDG
Authors: Nainggolan Romauli , Padmalia Metta , Sitepu Rismawati , Andrina Anak Agung Ayu Puty , Win Thinzar 
Published: February 2025

Objective: The objective of this study is to examine the impact of a digital financial literacy program on the financial performance of micro, small, and medium enterprises in West Java and North Sumatra. The aim is to evaluate the effectiveness of the program in improving digital financial literacy and financial outcomes for MSMEs owners, thereby contributing to SDG goal 8 (Decent Work and Economic Growth).

Theoretical Framework: This research is grounded in theories of financial literacy. Key frameworks include the six dimensions of digital financial literacy: financial knowledge, digital knowledge, practical know-how, awareness, decision-making, and self-protection. These dimensions provide a robust basis for assessing the intervention's impact.

Method: A quasi-experimental design was employed, involving 107 MSMEs owners who use QRIS as a digital payment tool. The sample was divided into a treatment group (n=54, Medan, North Sumatra) and a control group (n=53, Gresik, West Java). The intervention included six weekly sessions covering the six digital financial literacy dimensions. Data were collected via pre- and post-tests, analyzed using paired t-tests and independent sample t-tests, with a 5% significance threshold.

Results and Discussion: This study reveals that there were no significant differences in pre-test scores between the treatment and control groups. However, the treatment group showed a significant increase in digital financial literacy scores compared to the control group in the post-test. The experimental group demonstrated a greater improvement in financial performance among MSMEs in North Sumatra compared to those in West Java.

Research Implications: This study highlights the need for targeted digital financial literacy programs to boost MSME performance and reduce disparities. It supports SDG goal 8 by emphasizing sustainable micro-enterprises to enhance economic productivity. Policymakers should promote tailored training and collaborative technology adoption.

Originality/Value: By testing a multi-dimensional digital financial literacy program within an Indonesian MSMEs context, this study underscores the critical role of digital literacy in improving financial performance and fostering inclusive economic growth.
Sustainable Development Goals in Action: Circular Economy Strategies and ESG Environmental Practices in a Plastic Injection Molding Company
Authors: Hsu Chang-Hsien , Chen Ching-Chung , Su Yin-Chieh , Hsieh Chih-Chien 
Published: February 2025

Objective: This study investigates how a plastic injection molding company integrates circular economy strategies to reduce waste and carbon emissions while achieving cost efficiencies, aligning these efforts with the goals of Sustainable Development Goal (SDG) 12, which emphasizes responsible consumption and production.

Theoretical Framework: The research is grounded in ESG environmental principles and Sustainable Development Goal (SDG) 12, emphasizing responsible consumption and production. Circular economy concepts underpin the analysis, focusing on resource efficiency and waste minimization.

Method: Qualitative methods, including in-depth interviews, on-site observations, and secondary data analysis, were used to examine the company’s ABS plastic recycling practices.

Results and Discussion: The company reduced virgin material usage and carbon emissions by implementing innovative recycling techniques. Annually, approximately 320 kilograms of ABS waste are recycled, lowering production costs by 9.3% and reducing CO₂ emissions by 860.8 kg.

Research Implications: This study demonstrates the practical application of circular economy principles in manufacturing, highlighting their dual benefits of environmental sustainability and economic performance.

Originality/Value: By focusing on the alignment of circular economy practices with SDG 12, this study provides actionable insights for manufacturers aiming to integrate ESG practices. The findings offer a replicable model for achieving sustainable development and advancing global SDG targets in resource-intensive industries.
Common Method Bias in Social and Behavioral Research: Strategic Solutions for Quantitative Research in the Doctoral Research
Authors: Polas Mohammad Rashed Hasan 
Published: February 2025

This paper addresses the critical issue of common method bias (CMB) in social and behavioral research, emphasizing its impact on the validity and reliability of quantitative studies, particularly in the context of doctoral-level research. CMB arises when data collection methods in doctoral research, such as self-report surveys, artificially inflate or deflate relationships between variables, leading to distorted findings. This can result in misleading conclusions, such as overstating the link between job satisfaction and employee performance, which may have serious implications for both academic research and policymaking. The paper offers a comprehensive overview of the sources and effects of CMB, along with strategies to detect, prevent, and control it. It highlights key statistical techniques, including Harman’s single-factor test, marker variable approaches, and latent variable modeling, to minimize bias during data analysis. Additionally, it outlines best practices for study design, such as temporal separation, varying measurement methods, and ensuring data collection anonymity, to reduce CMB from the outset. By implementing these strategies, researchers can enhance the validity and generalizability of their findings, ensuring that results reflect genuine relationships rather than artifacts of the research process.

Received: 7 September 2024 | Revised: 31 October 2024 | Accepted: 23 Januray 2025

Conflicts of Interest
The author declares that he has no conflicts of interest to this work.

Data Availability Statement
Data sharing is not applicable to this article as no new data were created or analyzed in this study.

Author Contribution Statement
Mohammad Rashed Hasan Polas: Conceptualization, Methodology, Software, Validation, Formal analysis, Investigation, Resources, Data curation, Writing – original draft, Writing – review & editing, Visualization, Supervision, Project administration.
PRIMARY AMENORRHEA AND KABUKI SYNDROME
Authors: Arifiandi Maya Devi , Aditya Nugraha Bayu , Hendarto Hendy , Sa'adi Ashon , Dwiningsih Sri Ratna , Yanuar Annas Jimmy , Hardianto Gatut , Ardianta M.Y. 
Published: February 2025

Introduction: Kabuki Syndrome (KS) has been reported in all ethnicities with an estimated prevalence of 1:32,000 to 1:86,000. Diagnosing and managing Kabuki Syndrome is quite difficult. Its management depends on the presenting manifestations and therefore requires multidisciplinary collaboration. Case: A 24-year-old woman came to the hospital complaining of an enlarged abdomen and abdominal pain. In the anamnesis, information was obtained that at birth, atresia ani was found, surgery was performed when she was 2 weeks old.
CORRECT DIAGNOSIS OF DENTAL ANOMALIES
Authors: Astanovich Akhmedov Alisher , Burkhon Ravshanovich Khojimurodov , Mukhiddin Sarimsakovich Gubaev 
Published: February 2025

Dental anomalies, encompassing a wide range of structural, developmental, and functional deviations, can significantly affect the oral health of individuals. Early diagnosis is crucial in ensuring proper management and preventing the progression of these anomalies. This study aims to review the diagnostic approaches to various dental anomalies, focusing on advanced imaging techniques, clinical evaluation, and genetic factors. We discuss the significance of a multidisciplinary approach to diagnosis and treatment, emphasizing the role of dental professionals in detecting abnormalities early in their development. Furthermore, we explore the role of genetics and environmental factors in the manifestation of these anomalies. The study highlights the need for improved diagnostic protocols and innovative treatment modalities that will enhance patient care.
Dom Frei Eduardo José Herberhold, O.F.M.:
Authors: Costa Ribeiro Oslan 
Published: February 2025

O presente propõe lançar novos olhares sobre as ações pastorais de D. Frei Eduardo José Herberhold, da Ordem dos Frades Menores, segundo Bispo da Diocese de Ilhéus, contextualizando sua trajetória eclesiástica desde sua eleição e ordenação episcopal, sua passagem por Santarém, no Pará, depois sua nomeação, posse e analisar início de seu governo pastoral na Diocese de Ilhéus, na região sul da Bahia, entre 1931-1932, recorte temporal objeto deste trabalho. Utilizando de fontes impressas, cartas oficiais e registros fotográficos do seu acervo pessoal, procuramos entender quem foi esse importante personagem da história de Ilhéus no século XX, dialogando sobre as possibilidades de interpretação histórica através da biografia, fotografia e literatura. Buscamos também a coerência sobre o assunto, quando por meio de notas explicativas, contextualizamos através de citações dos documentos da Igreja, como: o Código de Direito Canônico (1983) e do Catecismo da Igreja Católica (1992), dando maior entendimento sobre o assunto no que tange a Igreja Católica em sua organização interna e doutrina, por vezes não compreendidos no cotidiano da vida secular.
Design of Automotive Software Upgrade Simulation Test Bench
Authors: Zhu Yongjian , Jing Ying , Wang Manna , Wang Yuzhe , Liu Kaiquan 
Published: February 2025

With the rapid development of automotive electronics technology, automotive software upgrades have become an indispensable part of the modern automotive industry. To ensure the safety and reliability of software upgrades, the design of simulation test benches has become particularly important. This article aims to explore a design scheme for an automotive software upgrade simulation test bench. Through a detailed analysis of the hardware and software architecture of the bench, an integrated testing platform is proposed. This platform can simulate real car operating environments and conduct comprehensive testing of software upgrade processes, including functional verification, performance testing, compatibility testing, etc. The effectiveness and practicality of the test bench have been verified through practical application cases. This study provides a new solution for automotive software upgrade testing, which helps to improve the quality and efficiency of automotive software upgrades.
Ischemic colitis with small-vessel occlusion, simultaneous total colectomy and liver transplantation: A case report
Authors: Kasputis Zanini Leonardo Yuri , Lima Fabiana Roberto , Fernandes Michel Ribeiro , Alvarez Paola Sofia Espinoza , Silva Marcello de Souza , Martins Filho Antônio Paulo Ramos , Franzini Tomazo Antonio Prince , Nacif Lucas Souto 
Published: February 2025

BACKGROUND
The colon is the hollow viscera that proportionally has the lowest vascular supply and is more predisposed to ischemic colitis. In the context of end-stage liver disease, various components may explain this group's greater predisposition to colonic ischemic events. Furthermore, portal hypertension generates a process of coagulopathy, impairing local vascularization. This case report describes a case of ischemic colitis with small-vessel occlusion found during liver transplantation in a patient with decompensated end-stage liver disease.
CASE SUMMARY
A 64-year-old man with liver cirrhosis due to non-alcoholic steatohepatitis and hepatocellular carcinoma. The patient underwent liver transplantation due to hepatic decompensation. The donor was a 53-year-old man who had died of a hemorrhagic stroke. Cavitary examination revealed diffuse ischemic colitis with significant distention and necrosis. Due to the condition of the colon, a subtotal colectomy was performed. Liver transplantation with warm ischemia time of 35 minutes, cold ischemia of 6 hours 30 minutes and total ischemia time of 7 hours 5 minutes. The patient improved clinically with oral tract function and physiotherapy, but unfortunately, he developed a bloodstream infection, a new septic shock and died six months after surgery.
CONCLUSION
Simultaneous total colectomy and orthotopic liver transplantation represent a rare situation. Ischemic events have a high mortality rate in the general population and are particularly important in cirrhotic patients.