bluuebunny/crossref_metadata_2025_split huggingface dataset:
Immunoadsorption and plasmapheresis at the ICU – A description of the frequencies and indications in a single center experience and a case report
Authors: Koball Sebastian , Rogge Johannes , Frimmel Silvius , Hinz Michael , Mitzner Steffen 
Published: December 2022

AbstractImmunologically mediated diseases can lead to severe courses that have to be treated in an intensive care unit. The use of extracorporeal organ support systems (ventilation, ECMO) is common. A therapeutic principle for these diseases is the removal of disease‐causing antibodies. This can be done nonspecifically by plasmapheresis or specifically by immune adsorption. While most intensive care units have the facilities for plasmapheresis (membrane plasma filtration), immunoadsorption is much less common. Over a period of 10 years, the numbers of immunoadsorption and plasmapheresis treatments performed in a single center intensive care unit are shown according to their indication (IA: 18 Pts, 58 treatments. PA: 54 Pts, 148 treatments). A case study of a patient with granulomatosis with polyangiitis shows the successful treatment with immunoadsorption. The advantages of immunoadsorption in patients with complex coagulation disorders and a critical clinical picture in terms of SIRS and ARDS are shown.
Regulating humanity's impact on the earth: The promise of transnational environmental law
Authors: Webster Emily 
Published: December 2022

AbstractTransnational environmental law (TEL) is a relatively new field of research that is agitated by the concept of the Anthropocene. Like environmental law, TEL suffers from certain methodological challenges which are exacerbated by the sheer ammount of activity involved in the generation of transnational legal norms and regulation. This article argues that, despite some of these challenges, TEL is well placed to evolve further to better regulate human activity in the Anthropocene. It argues that to better reflect on what the Anthropocene means for TEL and how it may develop in practice, it must engage further with power, the problem of erasure of weaker actors, and the legacies of colonialism on the one hand, and the sciences – particularly Earth system science and ecology ‐ on the other. By doing so it would offer a more robust analysis of TEL and insights into its further development in practice.
Risk of accidents and unintentional injuries in men and women with attention deficit hyperactivity disorder across the adult lifespan
Authors: Libutzki Berit , Neukirch Benno , Kittel‐Schneider Sarah , Reif Andreas , Hartman Catharina A. 
Published: December 2022

AbstractIntroductionAttention deficit hyperactivity disorder (ADHD) is associated with risk‐taking behavior, leading to accidents and unintentional injuries (summarized here as incidents). Main aim of this study is to determine if men and women with and without ADHD differ in the risk of mild (treated outpatient) and severe (treated inpatient) incidents across the adult lifespan (age groups: 18–29; 30–59, and ≥60 years). Secondary aim: investigate the role of comorbid mental disorders and drugs for the treatment of these comorbidities, and ADHD‐medication.MethodsUsing anonymized German claims data (N = 4,575,027), adults with ADHD diagnosis during 2016–2019 (N = 17,041) were compared with a 1:4 age and sex‐matched group without ADHD diagnosis. Regression analyses statistically tested group differences.ResultsIncidents occur in a U‐shaped form across the adult lifespan. Individuals with ADHD show the same pattern but at a substantially increased risk of both mild and severe incidents throughout the lifespan. Women without ADHD are at lower risk in young adulthood than men but at higher risk in older adulthood. Women with ADHD show the same pattern for severe incidents, but for mild incidents they have the highest risk throughout the lifespan. Co‐occurring anxiety disorder and the use of psycholeptics and ADHD‐medication decreased the incident risk.ConclusionWe extend available knowledge which has hitherto focused on young adult males and traffic accidents. ADHD is associated with increased incidents across the adult lifespan, with distinct patterns regarding age, sex, and incident severity. An accurate diagnosis of ADHD in adulthood provides the first step towards prevention of accidents and unintentional injuries.
Benefits of protected area networks for breeding bird populations and communities
Authors: Sanderson F. J. , Wilson J. D. , Franks S. E. , Buchanan G. M. 
Published: December 2022

AbstractProtected areas are a cornerstone of international conservation. The EU Natura 2000 network is the largest coordinated network of protected areas in the world, but its impact on biodiversity at the landscape scale is largely unknown. Here, we use data from Breeding Bird Survey (BBS) survey squares across Britain to test whether species abundance and population trends and levels of bird community specialisation are correlated with protected area coverage of BBS survey squares or 5‐km buffers around BBS squares. We compared area coverage by Natura 2000 protection and by the less strict protection of Sites of Special Scientific Interest protection alone. The abundance of birds of higher conservation concern and an index of community specialisation were positively correlated with coverage by protected area within survey squares and in a 5‐km buffer around squares. Population trends of species of higher conservation concern were positively correlated with the coverage of squares by Sites of Special Scientific Interest and the coverage of Natura 2000 within a 5‐km buffer around squares. The results suggest that Natura 2000 protection, in particular has positive conservation benefits for birds of higher conservation concern and community specialisation. This highlights the importance of protected areas, especially those with strictest protection, for maintaining biodiversity. Post‐Brexit, the UK should adopt legislation that results in the maintenance and strengthening of the current protected area network, as enforcing protection at a level of that provided by the Nature Directives is essential. As currently around half of Natura 2000 sites are not in favourable condition, even greater conservation benefits might be accrued if protected area management were improved.
Editorial: safety and efficacy of infliximab and corticosteroids in checkpoint inhibitor‐induced colitis
Authors: Hanauer Stephen , Wang Yinghong , Shatila Malek 
Published: December 2022

LINKED CONTENTThis article is linked to Dahl et al papers. To view these articles, visit https://doi.org/10.1111/apt.17201 and https://doi.org/10.1111/apt.17250
Editorial: the acid test – can bile acids predict recurrence of Clostridioides difficile infection?
Authors: Lo Sheng Wei , Segal Jonathan P. 
Published: December 2022

LINKED CONTENTThis article is linked to Mullish et al papers. To view these articles, visit https://doi.org/10.1111/apt.17247 and https://doi.org/10.1111/apt.17303
Editorial: ustekinumab during pregnancy—reassuring but still not enough. Authors' reply
Authors: Shitrit Ariella Bar‐Gil , Avni‐biron Irit 
Published: December 2022

LINKED CONTENTThis article is linked to Avni‐Biron et al papers. To view these articles, visit https://doi.org/10.1111/apt.17224 and https://doi.org/10.1111/apt.17260
Eurasian Grey and White wolf ancestors—800,000 years evolution, adaptation, pathologies and European dog origins
Authors: Diedrich Cajus G. 
Published: December 2022

AbstractThe oldest known wolf appears 800,000 years ago (Marine Isotope Stage 21) in Eurasia with the unspecialized short‐legged old Mammoth steppe wolfCanis lupus bohemicanov. spec. From this species, about 600,000–420,000 years ago (MIS 15‐11), the interglacialCanis lupus mosbachensis(Soergel, 1925) short‐legged Mosbach grey wolf subspecies roamed Eurasia. In the late Middle Pleistocene, there are two lineages, the southern interglacial grey and northern glacial White wolves in Eurasia. Since 320,000 (MIS 8), the short‐legged White wolfCanis lupus spelaeus(Goldfuss, 1823) was the glacial Mammoth steppe‐adapted wolf. Parallel to the “cave wolf” (found in the German Zoolithen Cave), the warm climate grey wolfCanis lupus brevisKuzmina and Sablin, 1994 existed.C.l.spelaeusrelates to the Holocene (MIS 1) extant Holarctic GreenlandCanis lupus arctosand SiberianCanis lupus albus(Kerr, 1792). The Late Palaeolithic (MIS 2) “Gravettian Goyet dogs” fall into the DNA pool ofC.l.spelaeusand are identified herein as pathological bite trauma individuals, which braincase shortened during the healing process. European prehistoric Neolithic dogs seem to have been imported from Central Asia with the Bandkeramik people (approx. 7000 BP) first, which have the stepped frontals originating from grey wolves.
Transforming the Quality Maternal Newborn Care Framework into an index to measure the quality of maternity care
Authors: Cummins Allison , Symon Andrew 
Published: December 2022

AbstractBackgroundThe Quality Maternal and Newborn Care (QMNC) Framework describes the care that childbearing women and newborn infants need in all settings. It comprises five components and was designed for use in planning, workforce development, and resource allocation, aimed at improving the quality and cost effectiveness of maternal and newborn care globally. The purpose of this paper is to describe the first phase of a project designed to transform the Framework into a quantitative tool for service user assessment of the quality of maternity care.MethodsEach component of the original Framework content was developed into a draft service user questionnaire and distributed to an expert panel, drawn from a range of low‐, middle‐, and high‐resource countries. The panel consisted of five Framework authors, nine midwife researchers, six midwives, and five service user (consumer) advocates. Two rounds of discussion and revision were undertaken with the expert panel who commented on the importance, relevance and clarity of questions, and then on their necessity, wording, and order. A third round involved two experts in survey design.ResultsFollowing 24 responses in the first round, the questions were refined and returned to the panel. After incorporating the second‐round comments from 16 experts, the survey was then sent to two experts in questionnaire design and construction. Face validity was affirmed through this consultative process.ConclusionsDespite Covid‐19 pandemic‐related restrictions, this robust iterative consultative process with an international expert panel has resulted in the prototype QMNC Framework index (QMNCFi)—a questionnaire designed for use in diverse settings to assess the quality of maternity care. The QMNCFi's psychometric properties are now being tested in an international online survey.
Do ridesharing services cause traffic congestion?
Authors: Pang Jindong , Shen Shulin 
Published: December 2022

AbstractThis paper uses a difference‐in‐differences strategy and an event‐study analysis to evaluate the effect of Uber entries on vehicle miles travelled in 346 US Metropolitan statistical areas between 2011 and 2017. Empirical results demonstrate that Uber entries have no significant effect on the total vehicle miles travelled in a city. However, Uber is found to decrease the vehicle miles travelled on highways but increase them on collector roads. All these effects come mainly from large metropolitan statistical areas. A simulation exercise suggests that Uber entries cause longer travel times if the share of travel time spent on collector roads is high.
A rare complication of double prosthetic valve endocarditis; reconstructive surgical treatment of mitral‐aortic intervalvular fibrosa pseudoaneurysm and left atrial fistula
Authors: Kahraman Nail , Topal Dursun , Altunal Ayşe Merve , Tiryakioğlu Selma Kenar , Taner Temmuz , Demir Deniz , Levent Çetin Mustafa 
Published: December 2022

AbstractMitral aortic intervalvular fibrosa or aorto‐mitral curtain is a fibrous avascular skeletal structure located between the anterior leaflet of the mitral valve and the non‐coronary and left coronary cusps of the aortic valve. Mitral and aortic valve endocarditis are rarely accompanied by mitral aortic intervalvular fibrosa pseudoaneurysm and left atrial fistula of the aorta. Pseudoaneurysm of mitral aortic intervalvular fibrosa is a fatal complication that can occur after valvular surgery, valvular endocarditis, or blunt trauma. In this article, reconstructive surgical management with the Commando technique of a case who developed mitral‐aortic intervalvular fibrosa pseudoaneurysm to left atrial fistula after aortic and mitral prosthetic valve endocarditis is described. The important feature of this article is that it is a first in the literature as it is accompanied by persistent left superior vena cava.
Bilateral dural arteriovenous fistula diagnosed with neurovascular ultrasonography
Authors: Psychogios Klearchos , Georgios Magoufis , Safouris Apostolos , Kargiotis Odysseas , Athina Andrikopoulou , Palaiodimou Lina , Chondrogianni Maria , Bakola Eleni , Tsivgoulis Georgios 
Published: December 2022

AbstractBackgroundIntracranial dural arteriovenous fistulas (dAVFs) are pathological anastomoses between meningeal arteries and dural venous sinuses or cortical veins. Diagnosis of dAVFs can be challenging due to their broad range of clinical manifestations and the lack of specificity in their symptoms. We present a rare case of a patient with bilateral dAVFs, who was referred to our department for carotid doppler ultrasonography/transcranial color Doppler.Case ReportA 67‐year‐old man was referred by his treating physician for neurovascular ultrasonography due to vision impairment associated with papilledema of both eyes. On ultrasound examination both external carotid arteries showed a “pseudo‐internalization” pattern with high end‐diastolic velocities and reduced resistance indices. Subsequent magnetic resonance and digital subtraction angiography revealed dAVF of both transverse sinuses, with occipital and medial meningeal arteries as feeders.ConclusionsNeurovascular sonography may serve as a screening and follow‐up tool when a DAVF in the transverse sinus/sigmoid sinus is suspected.
Does skilled labor risk matter to suppliers? Evidence from trade credit
Authors: Khoo Joye , Cheung Adrian (Wai Kong) 
Published: December 2022

AbstractFailure to attract and retain skilled labor exposes firms to skilled labor risk. This paper examines whether and how skilled labor risk affects trade credit offered by suppliers. The empirical analyses show that firms with greater exposure to skilled labor risk are associated with a reduction in trade credit granted by suppliers. It is consistent with the view that the risk arising from the departures of skilled employees is detrimental to firms. A change in employees who are well‐connected with the suppliers undermines firms’ bargaining power with their suppliers. Organization capital, managerial ability, and financial constraint are important moderators.
Atypical lipomatous tumour/well‐differentiated liposarcoma found in the buccal mucosa: A rare case report
Authors: Lee You‐Jung , Choi So‐Young 
Published: December 2022

AbstractOral liposarcomas are uncommon diseases, the most predominant histopathological subtype being atypical lipomatous tumour/well‐differentiated liposarcoma. In regard to its clinical aspects in the oral cavity, it is challenging to confirm a diagnosis and develop a treatment plan. In this case report, we present a rare case of atypical lipomatous tumour/well‐differentiated liposarcoma in the right cheek of a 77‐year‐old male patient. Conservative surgery was performed considering the histopathological subtype of the neoplasm. Knowledge of the clinical and histopathological characteristics of this rare disease is essential to maintaining function and aesthetics through conservative treatment in older patients.
Laying the foundations for gene therapy in Italy for patients with haemophilia A: A Delphi consensus study
Authors: Castaman Giancarlo , Carulli Christian , De Cristofaro Raimondo , Follino Marco , Lupi Angelo , Mancuso Maria Elisa , Mansueto Maria Francesca , Molinari Angelo Claudio , Pasquetti Pietro , Santoro Cristina , Santoro Rita Carlotta , Siragusa Sergio , Solimeno Luigi Piero , Tripodi Armando , Zanon Ezio , Minno Giovanni Di 
Published: December 2022

AbstractIntroductionCurrent treatment for haemophilia A involves factor VIII replacement or non‐replacement (emicizumab) therapies, neither of which permanently normalise factor VIII levels. Gene therapy using adeno‐associated viral (AAV) vectors is an emerging long‐term treatment strategy for people with severe haemophilia A (PwSHA) that is likely to be available for clinical use in the near future.AimThis article proposes practical guidelines for the assessment, treatment, and follow‐up of potential PwSHA candidates for AAV‐based gene therapy.MethodUsing the Delphi method, a working group of Italian stakeholders with expertise in and knowledge of the care of adults with haemophilia A analysed literature for AAV‐based gene therapy and drafted a list of statements that were circulated to a panel of Italian peers. During two rounds of voting, panel members voted on their agreement with each statement to reach a consensus.ResultsThe Delphi process yielded 40 statements regarding haemophilia A gene therapy, across five topics: (1) organisational model; (2) multidisciplinary team; (3) patient engagement; (4) laboratory surveillance; and (5) patient follow‐up and gene therapy outcomes. The consensus was reached for all 40 statements, with the second round of voting needed for five statements.ConclusionUse of the hub‐and‐spoke organisational model and multidisciplinary teams are expected to optimise patient selection for gene therapy, as well as the management of dosing and patient follow‐up, patient engagement, laboratory surveillance, and patient expectations regarding outcomes. This approach should allow the benefits of AAV‐based gene therapy for haemophilia A to be maximised.
Survey of recurrent diagnostic challenges in breast phyllodes tumours
Authors: Tan Benjamin Yongcheng , Fox Stephen B , Lakhani Sunil R , Tan Puay Hoon 
Published: December 2022

BackgroundBreast phyllodes tumours (PTs) are graded as benign, borderline, or malignant by analysis of multiple histological features. PT grading is often inconsistent, likely due to variation in the weighting of grading criteria by pathologists.DesignThe hierarchy of use of diagnostic criteria was identified using a 20‐question survey.ResultsIn all, 213 pathologists from 29 countries responded. 54% reported 10–50 PT cases per year. Criteria considered key to PT diagnosis were: increased stromal cellularity (84.3%), stromal overgrowth (76.6%), increased stromal mitoses (67.8%), stromal atypia (61.5%), stromal fronding (59.0%), periductal stromal condensation (58.0%), irregular tumour borders (46.3%), and/or lesional heterogeneity (33.7%). The importance of grading parameters were: mitotic activity (55.5%), stromal overgrowth (54.0%), stromal atypia (51.9%), increased stromal cellularity (41.7%), and nature of the tumour border (38.9%). 49% would diagnose malignant PT without a full array of adverse features. 89% used the term “cellular fibroepithelial lesion (FEL)” for difficult cases; 45% would diagnose an FEL with stromal fronding (but lacking other PT features) as fibroadenoma (FA), 35% FEL, and 17% PT. 59% deemed clinico‐radiological findings diagnostically significant; 68% considered age (≥40 years) important in determining if an FEL was a FA or PT. In FELs from young patients, increased stromal cellularity (83%), fronding (52%), and mitoses (41%) were more common. 34% regarded differentiating cellular FA from PT as a specific challenge; 54% had issues assigning a borderline PT grade.ConclusionCriteria for grading PT lie on a spectrum, leading to interpretive variability. The survey highlights the criteria most used by pathologists, which do not completely align with WHO recommendations.
Refining the Lorenz‐ranking of rules for claims problems on restricted domains
Authors: Mirás Calvo Miguel Ángel , Núñez Lugilde Iago , Quinteiro Sandomingo Carmen , Sánchez Rodríguez Estela 
Published: December 2022

AbstractThe comparison of the central rules for claims problems, according to the Lorenz order, has been studied not only on the entire set of problems but also on some restricted domains. We provide new characterizations of the adjusted proportional rule as being Lorenz‐maximal or Lorenz‐minimal within a class of rules on the half‐domains. Using this result, we rank the adjusted proportional, the minimal overlap, and the average‐of‐awards rules by analyzing whether or not these rules satisfy progressivity and regressivity on the half‐domains. We also find that the adjusted proportional rule violates two well‐known claim monotonicity properties.
Anti‐hypercholesteraemic and antioxidative activities of camel skin gelatin hydrolysate: effect of enzyme type, enzyme: substrate ratio and time of hydrolysis
Authors: Fawale Olumide Samson , Mudgil Priti , Abdelrahman Raghad , Baba Waqas N. , Nirmal Nilesh Prakash , Maqsood Sajid 
Published: December 2022

SummaryCamel skin gelatin hydrolysate (CSGH) was prepared using different proteolytic enzymes [alcalase (A), protease (P) and their combination (AP (1:1))], hydrolysis time (2, 4 and 6 h) and enzyme: substrate (E/S) ratio (1%, 3% and 5%). In general, the degree of hydrolysis (DH) increased with increasing hydrolysis time for all enzyme treatments. CSGHs generated with alcalase showed significantly higher lipase (LP) inhibitory activity compared with protease‐derived CSGH at all hydrolysis conditions (P < 0.05). Whereas higher cholesterol esterase (CE) inhibitory activity was observed with CSGH produced by protease (P < 0.05). However, when CSGHs were produced using AP, the highest LP and CE inhibitory activity were recorded at 3 and 1% E/S ratio during 2 and 4 h of hydrolysis, respectively (P < 0.05). Antioxidant assays revealed that CSGHs showed improved radical scavenging activities compared with native CSG (P < 0.05). Overall results indicated that CSGHs with higher in vitro anti‐hypercholesteraemic and antioxidant activities could be obtained by enzymatic hydrolysis.
Segmenter ou égaliser: le poids de deux modèles dans la pratique normative de l'OIT
Authors: HAHS Jenny , MÜCKENBERGER Ulrich 
Published: December 2022

RésuméDans son action normative, l'OIT a d'abord promu un modèle occidental, organisé autour de la relation de travail typique. Quand la voix du Sud et celle des femmes ont commencé à se faire entendre au sein de l'Organisation, un autre discours, axé sur l'égalité, a émergé, se superposant au précédent. Les auteurs font appel aux théories de l'institutionnalisme historique et de la structuration pour décrire cette évolution et le conflit normatif qui en a résulté, tout en observant la composition des effectifs de l'OIT et des délégations assistant aux sessions de la Conférence internationale du Travail. Plusieurs conclusions juridiques et recommandations d'action en découlent.