bluuebunny/crossref_metadata_2025_split huggingface dataset:
Responsive Polyphenol‐Crosslinked Supramacromolecular Microgels with pH‐Triggered Disassembly in Aqueous Solution
Authors: Molano‐López Catalina , Braun Susanne , Kather Michael , Töpel Alexander , van Wissen Gil , Pich Andrij 
Published: October 2022

AbstractThis work focuses on the pH‐triggered disassembly of supramacromolecular microgels, which are composed of the temperature‐responsive poly(N‐vinylcaprolactam) (PVCL) and the natural polyphenol tannic acid (TA). A systematic investigation of the microgel formation demonstrates that a retarded addition of tannic acid during semi‐batch precipitation polymerization influences the yield, chemical composition, and properties of the microgels to a great extent. Microgel properties, such as size, deformability, and chemical stability, can be easily tuned by varying the ratio between both building blocks PVCL and TA. Finally, the pH‐triggered disassembly of supramacromolecular microgels at different pH and temperatures demonstrates that their chemical structure can precisely control the degradation profile. Temperatures lower than the volume phase transition temperature (VPTT) of PVCL (T < 32 °C) and a pH > 10 result in a complete disassembly of the microgels into PVCL chains and TA due to the destruction of the hydrogen bonds responsible for the formation of a colloidal microgel. Interestingly, at temperatures above VPTT, the microgels keep their integrity due to enhanced hydrophobic interactions between the polymer chains of the microgel and are no longer affected by pH changes.
Integration in some new concept of ergodic functions and application to some epidemiological models
Authors: Ait Dads El Hadi , Lhachimi Lahcen 
Published: October 2022

In a former work, we introduced a new class of functions, which we call measure pseudo
‐asymptotically omega periodic functions and give some properties of those functions as the topological properties of the space of such functions, the invariance by translation of this space, and the convolution product in this space. In this paper, we consider the same class of functions and give contributions as the stability by the integral operator; we present some examples and composition results. Then we apply the obtained results to investigate the existence of measure pseudo
‐asymptotically omega periodic mild solutions for some nonlinear infinite delay integral equations arising in epidemiology; exactly, we consider the nonlinear infinite delay integral equation:

Then we apply these results to a finite delay integral equation when the delay is time dependent
Efficient dose–volume histogram–based pretreatment patient‐specific quality assurance methodology with combined deep learning and machine learning models for volumetric modulated arc radiotherapy
Authors: Gong Changfei , Zhu Kecheng , Lin Chengyin , Han Ce , Lu Zhongjie , Chen Yuanhua , Yu Changhui , Hou Liqiao , Zhou Yongqiang , Yi Jinling , Ai Yao , Xiang Xiaojun , Xie Congying , Jin Xiance 
Published: October 2022

AbstractBackgroundWeak correlation between gamma passing rates and dose differences in target volumes and organs at risk (OARs) has been reported in several studies. Evaluation on the differences between planned dose–volume histogram (DVH) and reconstructed DVH from measurement was adopted and incorporated into patient‐specific quality assurance (PSQA). However, it is difficult to develop a methodology allowing the evaluation of errors on DVHs accurately and quickly.PurposeTo develop a DVH‐based pretreatment PSQA for volumetric modulated arc therapy (VMAT) with combined deep learning (DL) and machine learning models to overcome the limitation of conventional gamma index (GI) and improve the efficiency of DVH‐based PSQA.MethodsA DL model with a three‐dimensional squeeze‐and‐excitation residual blocks incorporated into a modified U‐net was developed to predict the measured PSQA DVHs of 208 head‐and‐neck (H&N) cancer patients underwent VMAT between 2018 and 2021 from two hospitals, in which 162 cases was randomly selected for training, 18 for validation, and 28 for testing. After evaluating the differences between treatment planning system (TPS) and PSQA DVHs predicted by DL model with multiple metrics, a pass or fail (PoF) classification model was developed using XGBoost algorithm. Evaluation of domain experts on dose errors between TPS and reconstructed PSQA DVHs was taken as ground truth for PoF classification model training.ResultsThe prediction model was able to achieve a good agreement between predicted, measured, and TPS doses. Quantitative evaluation demonstrated no significant difference between predicted PSQA dose and measured dose for target and OARs, except for Dmean of PTV6900 (p = 0.001), D50 of PTV6000 (p = 0.014), D2 of PTV5400 (p = 0.009), D50 of left parotid (p = 0.015), and Dmax of left inner ear (p = 0.007). The XGBoost model achieved an area under curves, accuracy, sensitivity, and specificity of 0.89 versus 0.88, 0.89 versus 0.86, 0. 71 versus 0.71, and 0.95 versus 0.91 with measured and predicted PSQA doses, respectively. The agreement between domain experts and the classification model was 86% for 28 test cases.ConclusionsThe successful prediction of PSQA doses and classification of PoF for H&N VMAT PSQA indicating that this DVH‐based PSQA method is promising to overcome the limitations of GI and to improve the efficiency and accuracy of VMAT delivery.
Peripheral neuropathies associated with DNA repair disorders
Authors: Maguina Melissa , Kang Peter B. , Tsai Ang‐Chen , Pacak Christina A. 
Published: October 2022

AbstractRepair of genomic DNA is a fundamental housekeeping process that quietly maintains the health of our genomes. The consequences of a genetic defect affecting a component of this delicate mechanism are quite harmful, characterized by a cascade of premature aging that injures a variety of organs, including the nervous system. One part of the nervous system that is impaired in certain DNA repair disorders is the peripheral nerve. Chronic motor, sensory, and sensorimotor polyneuropathies have all been observed in affected individuals, with specific physiologies associated with different categories of DNA repair disorders. Cockayne syndrome has classically been linked to demyelinating polyneuropathies, whereas xeroderma pigmentosum has long been associated with axonal polyneuropathies. Three additional recessive DNA repair disorders are associated with neuropathies, including trichothiodystrophy, Werner syndrome, and ataxia‐telangiectasia. Although plausible biological explanations exist for why the peripheral nerves are specifically vulnerable to impairments of DNA repair, specific mechanisms such as oxidative stress remain largely unexplored in this context, and bear further study. It is also unclear why different DNA repair disorders manifest with different types of neuropathy, and why neuropathy is not universally present in those diseases. Longitudinal physiological monitoring of these neuropathies with serial electrodiagnostic studies may provide valuable noninvasive outcome data in the context of future natural history studies, and thus the responses of these neuropathies may become sentinel outcome measures for future clinical trials of treatments currently in development such as adeno‐associated virus gene replacement therapies.
Factors associated with strong opioid use for noncancer pain in patients with chronic intestinal failure
Authors: Deutsch Liat , Cloutier Anabelle , Leahy Gavin , Teubner Antje , Abraham Arun , Taylor Michael , Paine Peter , Lal Simon 
Published: October 2022

AbstractBackgroundChronic analgesic use is described in home parenteral nutrition (HPN)–dependent patients, but there are limited data on factors associated with opioid use for noncancerous pain.MethodsPatients attending a national UK intestinal failure reference center were divided in two groups according to strong opioid (SO) usage; risk factors for SO usage were analyzed using logistic regression.ResultsA total of 168 HPN‐dependent patients were included. During the study period, 73 patients (43.5%) had documented SO usage (SO group), whereas the remainder did not (No‐SO group). The prevalence of Crohn's disease among the No‐SO group was twofold higher than among the SO group (43.2% vs 24.7%; P = 0.013), whereas those with surgical complications were twice as prevalent among the SO group (19.2% vs 8.4%, respectively; P = 0.04). The rate of working‐age unemployment was significantly higher in the SO group (90.6%) than the No‐SO group (55.6%; P = 0.001). Multivariate regression showed unemployment as an independent risk factor for SO usage (OR, 6.005; 95% CI, 1.435–25.134), whereas Crohn's disease (OR, 0.284; 95% CI, 0.09–0.898) and <4 intravenous support (IVS) nights per week (OR, 0.113; 95% CI, 0.012–1.009) were protective factors. The life‐long incidence of catheter‐related bloodstream infection (CRBSI) was comparable between groups (34.2% SO vs 27.4% No‐SO; P = 0.336).ConclusionSO use is frequent among HPN‐dependent patients and associated with high rates of unemployment and ≥4 IVS nights per week, but not with increased rate of CRBSI. The reduced usage among patients with Crohn's disease warrants further evaluation but might be due to the chronicity as compared with other IF etiologies.
An a priori error analysis of a type III thermoelastic problem with two porosities
Authors: Bazarra Noelia , Fernández José R. , Quintanilla Ramón , Suárez Sofía 
Published: October 2022

AbstractIn this work, we study, from the numerical point of view, a type III thermoelastic model with double porosity. The thermomechanical problem is written as a linear system composed of hyperbolic partial differential equations for the displacements and the two porosities, and a parabolic partial differential equation for the thermal displacement. An existence and uniqueness result is recalled. Then, we perform its a priori error numerical analysis approximating the resulting variational problem by using the finite element method and the implicit Euler scheme. The linear convergence of the algorithm is derived under suitable additional regularity conditions. Finally, some numerical simulations are shown to demonstrate the accuracy of the approximations and the dependence of the solution on a coupling coefficient.
Computability of magnetic Schrödinger and Hartree equations on unbounded domains
Authors: Becker Simon , Sewell Jonathan , Tebbutt Euan 
Published: October 2022

AbstractWe study the computability of global solutions to linear Schrödinger equations with magnetic fields and the Hartree equation on . We show that the solution can always be globally computed with error control on the entire space if there exist a priori decay estimates in generalized Sobolev norms on the initial state. Using weighted Sobolev norm estimates, we show that the solution can be computed with uniform computational runtime with respect to initial states and potentials. We finally study applications in optimal control theory and provide numerical examples.
Insurance Subsidies, the Affordable Care Act, and Financial Stability
Authors: Dodini Samuel 
Published: October 2022

AbstractThis paper measures the effects of subsidies in the Affordable Care Act on adverse financial outcomes using administrative tax data and credit data on financial outcomes. Using a difference‐in‐differences design with propensity score reweighting, I find that at $100 per capita, ACA premium tax credits and cost‐sharing reduction subsidies reduced consumer bankruptcies and severe auto delinquency by 8 percent and 7 percent, respectively, and substantially reduced right‐tail delinquent debt and third‐party collections. The value of recipients’ risk protection against medical debt payments amounts to approximately 16 to 21 percent of the cash costs of the subsidies, while the subsidies provided substantial indirect transfers to external parties.
Imaging of pediatric testicular tumors: A COG Diagnostic Imaging Committee/SPR Oncology Committee White Paper
Authors: Behr Gerald G. , Morani Ajaykumar C. , Artunduaga Maddy , Desoky Sarah M. , Epelman Monica , Friedman Jonathan , Lala Shailee V. , Seekins Jayne , Towbin Alexander J. , Back Susan J. 
Published: October 2022

AbstractPrimary intratesticular tumors are uncommon in children, but incidence and risk of malignancy both sharply increase during adolescence. Ultrasound is the mainstay for imaging the primary lesion, and cross‐sectional modalities are often required for evaluation of regional or distant disease. However, variations to this approach are dictated by additional clinical and imaging nuances. This paper offers consensus recommendations for imaging of pediatric patients with a known or suspected primary testicular malignancy at diagnosis and during follow‐up.
Late mortality reduction among survivors of germ cell tumors in childhood and adolescence in Europe: A report from the PanCareSurFup cohort
Authors: Trama Annalisa , Bernasconi Alice , Botta Laura , Byrne Julianne , Grabow Desiree , Reulen Raoul C. , Calaminus Gabriele , Terenziani Monica 
Published: October 2022

AbstractBackgroundData on late mortality from pediatric germ cell tumors (GCTs) are limited to small case series. Our population‐based study aimed to investigate excess risk of death in survivors of GCT in childhood and adolescence, whether long‐term mortality changed over time and by period of diagnosis.MethodsThe PanCare Childhood and Adolescent Cancer Survivor Care and Follow‐Up Studies (PanCareSurFup) cohort includes 2773 five‐year survivors diagnosed under 21 years of age with gonadal and extragonadal GCT (from 1940 to 2008). We calculated standardized mortality ratios (SMRs) and absolute excess risks (AERs). We fitted a Cox's model to assess the impact of treatment period. We estimated 10‐year survival and calculated average percentage changes between periods of diagnosis (1970–1979, 1980–1989, 1990–1999) to assess whether late mortality decreased.ResultsGCT survivors had an almost four‐fold excess risk of dying compared to general population. The risk of death for patients treated after 1980 was nearly halved compared to patients treated before 1980. Survivors diagnosed in 1990–1999 had a 10‐year survival rate of 99%, which was 2.4% and 1.1% higher than for patients treated in 1970–1979 and 1980–1989, respectively.ConclusionsThis is the largest population‐based study in Europe and showed a decrease in long‐term mortality for survivors of GCTs in childhood and adolescence over the last decades. After the introduction of platinum compound in 1980, which is a paradigm of success compared to the previous treatments, no major changes in drug therapies have been made to treat GCTs in the last 40 years. However, GCT survivors maintain an excessive risk of death that requires long‐term care.
Imaging of pediatric ovarian tumors: A COG Diagnostic Imaging Committee/SPR Oncology Committee White Paper
Authors: Behr Gerald G , Morani Ajaykumar C. , Artunduaga Maddy , Desoky Sarah M , Epelman Monica , Friedman Jonathan , Lala Shailee V , Seekins Jayne , Towbin Alexander J. , Back Susan J. 
Published: October 2022

AbstractOvarian tumors in children are uncommon. Like those arising in the adult population, they may be broadly divided into germ cell, sex cord, and surface epithelium subtypes; however, germ cell tumors comprise the majority of lesions in children, whereas tumors of surface epithelial origin predominate in adults. Diagnostic workup, including the use of imaging, requires an approach that often differs from that required in an adult. This paper offers consensus recommendations for imaging of pediatric patients with a known or suspected primary ovarian malignancy at diagnosis and during follow‐up.
Long‐term result of 125I seed brachytherapy for pediatric desmoid tumor in the head and neck
Authors: Zhong Yi‐Wei , Lyu Xiao‐Ming , Shi Yan , Guo Chuan‐Bin , Zhang Jian‐Guo , Zheng Lei 
Published: October 2022

AbstractBackgroundDesmoid tumor (DT) is rare and challenging, often affects the head and neck (HN) region in children, and its appropriate treatments are under‐discussed. This study aimed to retrospectively evaluate the long‐term effectiveness and safety of 125I seed brachytherapy for pediatric DT in HN.ProcedureSeven pediatric patients with a median age of three years who suffered from DT in HN treated with 125I brachytherapy from January 2008 to June 2018 were included. Among these, five underwent sole brachytherapy and the others combined with surgery under prescription doses ranging from 10,000 to 12,000 cGy. The rate of local control (LC), complete response (CR), and partial response (PR) was calculated after evaluation by radiological and pathological means. Radiation‐associated toxicities were also evaluated.ResultsThe LC rate was 7/7 during the follow‐up time ranging from 43 to 135 months and with a mean of 57 months. No recurrent lesion was found in the patients receiving surgery combined with brachytherapy. In patients treated with sole brachytherapy, the radiological PR rate and CR rate were 4/5 and 1/5, respectively. In those reaching radiological PR, 3/4 were pathological CR. Slight acute radiation‐associated toxicities were observed in all patients, and no late or severe acute toxicity was observed.Conclusion125I brachytherapy is effective and safe in the management of pediatric DT in HN as the sole modality or combined with surgery in the long term.
Emotion‐regulation goals in people with high trait anxiety
Authors: Jiang Wen , Zhou Xiaolu , Lui Simon S. Y. , Chan Raymond C. K. 
Published: October 2022

AbstractThis study examined the goals of emotion‐regulation in people with high levels of trait anxiety using the Stimulus Selection Task and self‐report scales. People with high trait anxiety were more likely to choose to increase their levels of anxiety than those with low trait anxiety, across demanding and undemanding situations.
Predictors of the intentions to leave among nurses in an academic medical center
Authors: Sato Aoi , Sato Yoshiteru , Sugawara Norio , Shinozaki Masataka , Okayasu Hiroaki , Kawamata Yasushi , Tokumitsu Keita , Uchibori Yumiko , Komatsu Tomie , Yasui‐Furukori Norio , Shimoda Kazutaka 
Published: October 2022

AbstractAimNurses are an essential human resource for the healthcare system. However, high turnover of nurses is a current issue. Reducing the high turnover of nurses is crucial for facilitating the sustainable provision of care in hospitals. The purpose of this study was to explore the factors affecting nurses' intentions to leave among nurses in an advanced medical center.MethodsUsing a cross‐sectional design, we conducted a questionnaire survey of nurses working at an academic medical center in August 2020. Of the 1063 distributed questionnaires, there were 821 (77.2%) valid responses. The questionnaire included items on the Kessler 6 (K6), New Brief Job Stress Questionnaire (New BJSQ), Organizational Justice Questionnaire (OJQ), and intention to leave a hospital job.ResultsOverall, the mean age of the nurses was 34.3 ± 10.1 years and 87.8% (721/821) of them were female. Among respondents, 19.5% (160/821) had a strong intention to leave. After adjusting for all the variables, a logistic regression analysis revealed that longer working hours, job rank (staff nurse), work–self‐balance positive (imbalance), workplace harassment (no bullying), and interactional justice (unfair supervisor) were determinants associated with strong intentions to leave.ConclusionsApproximately one‐fifth of nurses working at advanced medical center had a strong intention to leave. However, our findings can help managers predict the turnover of nurses by understanding occupational characteristics. Managing work–self‐balance and treating staff fairly could improve work environments. Further research focusing on the outcome of actual turnover rather than intention to leave is needed.
Prenatal diagnosis of generalized arterial calcification of infancy in the second trimester
Authors: Pu Lihong , Dai Xiaohui , Liu Hanmin , Li Lei , Zhao Fumin , Chen Jiao 
Published: October 2022

AbstractObjectivesGeneralized arterial calcification of infancy (GACI) is a rare autosomal recessive disorder characterized by subintimal fibrous proliferation and deposition of calcium salts in the internal elastic lamina, leading to extensive arterial calcification and stenosis of large and medium‐sized arteries. Prenatal diagnosis is usually made in the third trimester by detection of aortic and pulmonary calcification with associated nonimmune hydrops; earlier prenatal diagnosis is rare. This study was performed to examine the prenatal ultrasound and genetic features of fetuses with GACI.MethodsWe retrospectively reviewed the ultrasound findings, their progression in utero, and the clinical features in three fetuses with GACI ascertained using ultrasound in the second trimester. GACI was subsequently confirmed through pathological examination and/or molecular genetic testing.ResultsAll three fetuses had hyperechogenic valves or annuli as the first detectable manifestation in the second trimester, followed by relatively rapid progression to arterial wall calcification. Three novel mutations of the ENPP1 gene associated with GACI were found in two of the cases (c.26dupG, c.1454A > G, and c.263C > G).ConclusionsGACI should be suspected when hyperechogenic cardiac valves, annuli, or arterial walls are noted after ruling out other causes of arterial calcification. Genetic testing is important for prenatal and future preimplantation genetic diagnosis.
Solomon versus selective fetoscopic laser photocoagulation for twin‐twin transfusion syndrome: A systematic review and meta‐analysis
Authors: Shamshirsaz Alireza A. , Chmait Ramen H. , Stirnemann Julien , Habli Mounira A. , Johnson Anthony , Hessami Kamran , Mostafaei Shayan , Nassr Ahmed A. , Donepudi Roopali V. , Sanz Cortes Magdalena , Espinoza Jimmy , Krispin Eyal , Belfort Michael A. 
Published: October 2022

AbstractThis meta‐analysis aims to compare the perinatal outcome of twin‐twin transfusion syndrome (TTTS) pregnancies undergoing selective versus vascular equator (Solomon) fetoscopic laser photocoagulation (FLP). We performed a systematic search in PubMed and Web of Science from inception up to 25 July 2021. Studies comparing the Solomon and selective techniques of FLP for treatment of TTTS pregnancies were eligible. Random‐effects or fixed‐effect models were used to pool standardized mean differences (SMD) and log odds ratio. Seven studies with a total of 1664 TTTS pregnancies (n = 671 undergoing Solomon and n = 993 selective techniques) were included. As compared to the selective FLP, Solomon was associated with a lower risk of recurrent TTTS compared to the selective technique (Log odds ratio [OR]: −1.167; 95% credible interval [CrI]: −2.01, −0.33; p = 0.021; I2: 67%). In addition, Solomon was significantly associated with a higher risk of placental abruption than the selective technique (Log [OR]: 1.44; 95% CrI: 0.45, 2.47; p = 0.012; I2: 0.0%). Furthermore, a trend for the higher risk of preterm premature rupture of membranes was observed among those undergoing Solomon (Log [OR]: 0.581; 95% CrI: −0.43, 1.49; p = 0.131; I2: 17%). As compared to selective FLP, the Solomon technique for TTTS pregnancies is associated with a significantly lower recurrence of TTTS; however, it significantly increases the risk of placental abruption.