bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hydrogelated Virus Nanoparticles in Tissue Engineering
Authors: Girigoswami Agnishwar , Gowtham Pemula , Pallavi Pragya , Harini Karthick , Girigoswami Koyeli 
Published: May 2022

Abstract:
Hydrogels are an integrated three-dimensional network of water-absorbing hydrophilic
polymers that can support tissue regeneration and release medication under controlled
conditions. Hydrogel-based structures physically resemble the extracellular matrix besides being
effective for biomedical applications and tissue engineering. Hydrogels must provide relevant
biological signals to control the cell behavior to become an ideal bioactive scaffold for tissue
regeneration. Incorporating virus nanoparticles (VNP) that can release essential peptides into the
hydrogels is a promising option to formulate a bioactive scaffold that can facilitate cell proliferation,
adhesion, migration, and differentiation. Over the recent period, virologists have discovered
many viruses that lead to a great understanding of the diversity of viruses in nature. Viruses
affecting the plants are called plant viruses, and they have a wide variety of shapes and sizes, yet
each species produces monodisperse nucleoprotein particles. Plant viruses are not capable of
infecting or reproducing in humans. Therefore, VNPs are engineered from plant viruses whose
genetically programmed structures can be manipulated at the gene level, bioconjugated, or encapsulated.
Plant VNPs can act as clinical diagnostic agents, immunomodulators, medicines,
nanoreactors, and biosensors by displaying protein molecules or epitopes, constructing inorganic
hybrid materials, or carrying molecular charges. The present review focuses on the plant virusmediated
nanoparticles encapsulated in bioactive hydrogels to provide an ideal platform for
tissue engineering.
Design, Optimization and Characterization of Combined Ethosomal
Transdermal Patch of Glimepiride and Duloxetine Drug Regimen for Diabetes
and Associated Neuropathic Pain Management
Authors: Aouta Eswar kumar , Patra Chinam Niranjan 
Published: May 2022

Background:
Diabetic neuropathic pain is the most prevalent type of neuropathic pain and
a major consequence of diabetes. A wide range of medications, whether administered alone or in combination,
have been found to dramatically decrease neuropathic pain.

Objective:
This study aimed to develop the glimepiride (GLM) and duloxetine (DUL) ethosomal
transdermal drug delivery patches to prolong and improve the discharge of the drug regimen to treat
diabetics as well as neuropathic pain associated with it.

Methods:
Using the solvent casting method, DUL and GLM ethosomal dispersions were formulated
by a 32 factorial design. A total of nine formulations were developed considering ethanol (X1) and
phospholipid (X2) independent factors, and the formulation was optimized based on entrapment efficiency
(Y1) and particle size (Y2). Moreover, size, surface charge, and % entrapment efficiency were
characterized. The ethosomal formulations converted into patches were characterized by thickness,
folding endurance, in vitro penetrability, and ex vivo skin permeability.

Results:
The results of thickness, % moisture content, % moisture uptake, and folding endurance were
in an acceptable range for all formulations. Based on the in vitro penetrability and ex vivo skin permeability
profile, formulation F9 was considered optimized, extending the cumulative drug release of
more than 60 % up to 24hrs and skin permeability of more than 200 μg/cm2.

Conclusion:
The investigation showed that the medication increment transdermal fix of GLM and
DUL was a promising path for the therapeutic management of diabetes and diabetic neuropathic pain.
The Impact of Affective Commitment and Leisure Satisfaction on Employees’ Quality of Life
Authors: Yuh Jongil 
Published: May 2022

Background:
Employees’ quality of life is affected by both work and private life domains. As interest in a whole-life perspective has recently grown, how employees’ attitudes toward work and leisure experiences are associated with their quality of life has gained increasing international attention.

Objective:
The purpose of this research was to examine the associations between affective commitment, leisure satisfaction, and employees’ quality of life and the moderating role of leisure satisfaction in the relationship between affective commitment and employees’ quality of life.

Methods:
A sample of 154 female childcare teachers completed self-reported questionnaires measuring their affective organizational commitment, leisure satisfaction, and quality of life. Data were obtained from 17 childcare centers in Seoul, Korea, during the summer of 2021, using convenience sampling. Pearson correlation, hierarchical regression analyses, and bootstrapping methods were used to test the hypotheses.

Results:
The results revealed that affective commitment and leisure satisfaction were positively related to female childcare teachers’ quality of life. Moreover, after controlling for age and marital status, leisure satisfaction was shown to play a moderating role, indicating that affective commitment was more strongly associated with quality of life for individuals who had a high level of leisure satisfaction.

Conclusion:
The findings underscore the significance of affective commitment and leisure satisfaction in enhancing female employees’ quality of life. The findings also highlight the consideration of leisure satisfaction as a target for intervention in enhancing female employees’ well-being.
Pickering Emulsions: A Potential Strategy to Limiting Cancer Development
Authors: Bhattacharya Sankha , Singh Sushil Kumar , Setia Aseem , Singh Shambhavi , Baghel Yudhishthir Singh , Joshi Deshbandhu 
Published: May 2022

Abstract:
Pickering Emulsion therapy is a novel approach to treating various human diseases, in-cluding cancer. Traditional cancer treatment modalities, such as surgery, radiation, radiotherapy, and immunotherapy, have only achieved minimal success. Pickering emulsion in cancer therapeu-tics has given cancer patients a new hope. Pickering Emulsions have grown in popularity over the last 15 years, owing to their highly desirable properties, similar to those of ordinary emulsions, namely their excellent stability. This review focused on the benefits, drawbacks, characterization parameters (droplet size and strength, for example), opportunities, and different development pro-cedures of Pickering Emulsion for cancer diseases. This review also addressed recent developments in Pickering Emulsions' technological issues. It examined the advantages and disadvantages of us-ing such formulations for topical pharmaceutical and cosmetic applications instead of traditional surfactant-based methods. Pickering Emulsion's evolution as a multifunctional dosage form carrier reflects renewed optimism in the pharmaceutical and cosmetic industries.
Role of Nanotechnology in Taste Masking: Recent Updates
Authors: Nagpal Manju , Vishvakarma Vivekanand , Kaur Malkiet , Arora Sandeep 
Published: May 2022

Abstract:
One of the important parameters in the case of dosage form is taste. Most of the drugs
available in oral dosage form have an unpleasant taste which leads to patient incompliance and
affects the success ratio of products in the market. Geriatric and paediatric patients suffer more
with the bitter taste of medicines. According to the studies reported, it is found that 50% of the
population have the problem swallowing tablets, especially the pediatric and geriatric population.
Masking the taste of bitter drugs has become necessary in the pharmaceutical field and increasing
interest of researchers to develop various methods for masking the bitter taste of drugs. Five major
tastes, felt by our tongue are salt, sour, sweet, bitter, and umami. When the drug dissolves with
saliva, drug molecules interact with taste receptors present on the tongue and give taste sensations.
Although, many solid oral dosage forms like pills, and tablets have an additional advantage of
masking and encapsulation of bitter taste drugs; however, they might not be effective for children
because they may or may not swallow pills or tablets. There are various other methods that mask
the bitter taste of drugs such as the addition of sweeteners and flavouring agents, granulation, coating,
inclusion complexes, extrusion method, ion-exchange resins, etc, discussed in the first section
of the article. The second part of this article consists of various nanotechnology-based drug delivery
systems that were fabricated by researchers to mask the bitter taste of drugs. A brief of recent
literature on various nanocarriers that were fabricated or developed for taste masking has been
discussed in this part. A better understanding of these methods will help researchers and pharmaceutical
industries to develop novel drug delivery systems with improved taste masking properties.
Critical Comparison of the Quality and Content of Integrated Vascular Surgery, Thoracic Surgery, and Interventional Radiology Residency Training Program Websites: Qualitative Study
Authors: Jensen Katherine , Yan Qi , Davies Mark G 
Published: May 2022

Background
With the move to virtual interviewing, residency websites are an important recruitment resource, introducing applicants to programs across the country and allowing for comparison. Recruitment is highly competitive from a common potential pool between vascular surgery, thoracic surgery, and interventional radiology with the ratio of applicants to positions being highest in interventional radiology, followed by thoracic surgery and lastly vascular surgery, as reported by the National Resident Matching Program.

Objective
The aim of this study is to evaluate the accessibility and availability of online content for those integrated residency programs.

Methods
A list of accredited vascular surgery, thoracic surgery, and interventional radiology residencies was obtained from the Accreditation Council for Graduate Medical Education (ACGME) database. Program websites were evaluated by trained independent reviewers (n=2) for content items pertaining to program recruitment and education (scored absent or present). Statistical analysis was performed in R software.

Results
Of ACGME-accredited programs, 56 of 61 (92%) vascular surgery, 27 of 27 (100%) thoracic surgery, and 74 of 85 (87%) interventional radiology programs had functional websites (P=.12). Vascular surgery websites contained a median of 26 (IQR 20-32) content items, thoracic surgery websites contained a median of 27 (IQR 21-32) content items, and interventional radiology websites contained a median of 23 (IQR 18-27) content items. Two content items considered highly influential to applicant program decisions are procedural experience and faculty mentorship, which were reported at 32% (18/56) and 11% (6/56) for vascular surgery, 19% (5/27) and 11% (3/27) for thoracic surgery, and 50% (37/74) and 15% (11/74) for interventional radiology (P=.008 and P=.75), respectively. Key deficits were work hours, debt management, and curriculum for interventional radiology; resident profiles, sample contracts, and research interests in vascular surgery; and operative experiences and the program director’s contact and message for thoracic surgery. Interventional radiology deficits were work hours, and thoracic surgery deficits were procedural experience. Both interventional radiology and thoracic surgery websites lacked information on evaluation criteria and faculty mentorship.

Conclusions
This study has uncovered key differences in the availability of online content for residencies recruiting from the same pool of applicants. Thoracic surgery has the most information, followed by vascular surgery, with interventional radiology reporting the least content. In the era of virtual interviewing from the same potential pool of applicants, programs should review and revise their web presence with the aim to increase the availability of online content to attract valuable candidates.
Cost-Effectiveness of Lung Cancer Screening Using Low-Dose Computed Tomography Based on Start Age and Interval in China: Modeling Study
Authors: Zhao Zixuan , Du Lingbin , Li Yuanyuan , Wang Le , Wang Youqing , Yang Yi , Dong Hengjin 
Published: May 2022

Background
Lung cancer is the most commonly diagnosed cancer and the leading cause of cancer-related death in China. The effectiveness of screening for lung cancer has been reported to reduce lung cancer–specific and overall mortality, although the cost-effectiveness, optimal start age, and screening interval remain unclear.

Objective
This study aimed to assess the cost-effectiveness of lung cancer screening among heavy smokers in China by incorporating start age and screening interval.

Methods
A Markov state-transition model was used to assess the cost-effectiveness of a lung cancer screening program in China. The evaluated screening strategies were based on a screening start age of 50-74 years and a screening interval of once or annually. Transition probabilities were obtained from the literature and validated, while cost parameters were derived from databases of local medical insurance bureaus. A societal perspective was adopted. The outputs of the model included costs, quality-adjusted life years (QALYs), and lung cancer–specific mortality, with future costs and outcomes discounted by 5%. A currency exchange rate of 1 CNY=0.1557 USD is applicable. The incremental cost-effectiveness ratio (ICER) was calculated for different screening strategies relative to nonscreening.

Results
The proposed model suggested that screening led to a gain of 0.001-0.042 QALYs per person as compared with the findings in the nonscreening cohort. Meanwhile, one-time and annual screenings were associated with reductions in lung cancer–related mortality of 0.004%-1.171% and 6.189%-15.819%, respectively. The ICER ranged from 119,974.08 to 614,167.75 CNY per QALY gained relative to nonscreening. Using the World Health Organization threshold of 212,676 CNY per QALY gained, annual screening from a start age of 55 years and one-time screening from the age of 65 years can be considered as cost-effective in China. Deterministic and probabilistic sensitivity analyses were conducted.

Conclusions
This economic evaluation revealed that a population-based lung cancer screening program in China for heavy smokers using low-dose computed tomography was cost-effective for annual screening of smokers aged 55-74 years and one-time screening of those aged 65-74 years. Moreover, annual lung cancer screening should be promoted in China to realize the benefits of a guideline-recommended screening program.
A Mobile Phone App Intervention to Promote Healthy Salt Intake Among Adults: Protocol for a Randomized Controlled Study
Authors: Perin Milena Sia , São-João Thais , Gallani Maria Cecília Bueno Jayme , Agbadje Titilayo Tatiana , Rodrigues Roberta Cunha Matheus , Cornélio Marilia Estevam 
Published: May 2022

Background
There is sound evidence associating high salt intake and a greater risk of cardiovascular and noncardiovascular diseases. High salt intake has been observed in several populations worldwide. Therefore, promoting healthier salt consumption has been encouraged as a low-cost strategy to reduce this risk factor. However, these strategies need to be sound, built on theoretical and methodological bases, and consider the target population’s context.

Objective
This protocol aims to describe a mobile phone app intervention to promote healthy salt intake among adults.

Methods
This is an experimental and longitudinal study protocol conducted in three modules. Module 1 refers to the planning of the intervention based on the Behaviour Change Wheel framework. Module 2 is the development of the mobile phone app intervention based on the date of module 1. In module 3, the intervention will be evaluated using a randomized controlled study, with three steps of data collection in a 2-month follow-up in a sample of 86 adults (43 participants for each group: the control group and intervention group) recruited from the primary health care centers of a Brazilian town. The discretionary salt intake questionnaire will assess salt consumption, the app usability will be assessed using the System Usability Scale, and psychosocial variables (habit, intention, and self-efficacy) will also be measured.

Results
Recruitment began in October 2021, and the follow-up will end in August 2022. The results of this study are expected to be published in 2023.

Conclusions
Results from this study will help people to control salt intake when cooking at home, will stimulate self-care, will work as an alternative or supportive method in the relationship between health care professionals and patients, and will contribute to implementing the app intervention to promote healthy salt intake on a large scale.

Trial Registration
The Brazilian Clinical Trials Registry RBR-4s8qyyq; https://ensaiosclinicos.gov.br/rg/RBR-4s8qyyq

International Registered Report Identifier (IRRID)
DERR1-10.2196/37853
Passive Mobile Self-tracking of Mental Health by Veterans With Serious Mental Illness: Protocol for a User-Centered Design and Prospective Cohort Study
Authors: Young Alexander S , Choi Abigail , Cannedy Shay , Hoffmann Lauren , Levine Lionel , Liang Li-Jung , Medich Melissa , Oberman Rebecca , Olmos-Ochoa Tanya T 
Published: May 2022

Background
Serious mental illnesses (SMI) are common, disabling, and challenging to treat, requiring years of monitoring and treatment adjustments. Stress or reduced medication adherence can lead to rapid worsening of symptoms and behaviors. Illness exacerbations and relapses generally occur with little or no clinician awareness in real time, leaving limited opportunity to modify treatments. Previous research suggests that passive mobile sensing may be beneficial for individuals with SMI by helping them monitor mental health status and behaviors, and quickly detect worsening mental health for prompt assessment and intervention. However, there is too little research on its feasibility and acceptability and the extent to which passive data can predict changes in behaviors or symptoms.

Objective
The aim of this research is to study the feasibility, acceptability, and safety of passive mobile sensing for tracking behaviors and symptoms of patients in treatment for SMI, as well as developing analytics that use passive data to predict changes in behaviors and symptoms.

Methods
A mobile app monitors and transmits passive mobile sensor and phone utilization data, which is used to track activity, sociability, and sleep in patients with SMI. The study consists of a user-centered design phase and a mobile sensing phase. In the design phase, focus groups, interviews, and usability testing inform further app development. In the mobile sensing phase, passive mobile sensing occurs with participants engaging in weekly assessments for 9 months. Three- and nine-month interviews study the perceptions of passive mobile sensing and ease of app use. Clinician interviews before and after the mobile sensing phase study the usefulness and feasibility of app utilization in clinical care. Predictive analytic models are built, trained, and selected, and make use of machine learning methods. Models use sensor and phone utilization data to predict behavioral changes and symptoms.

Results
The study started in October 2020. It has received institutional review board approval. The user-centered design phase, consisting of focus groups, usability testing, and preintervention clinician interviews, was completed in June 2021. Recruitment and enrollment for the mobile sensing phase began in October 2021.

Conclusions
Findings may inform the development of passive sensing apps and self-tracking in patients with SMI, and integration into care to improve assessment, treatment, and patient outcomes.

Trial Registration
ClinicalTrials.gov NCT05023252; https://clinicaltrials.gov/ct2/show/NCT05023252

International Registered Report Identifier (IRRID)
DERR1-10.2196/39010
Sintomatología ansiosa en estudiantes de universidades dominicanas durante COVID-19
Authors: Frías-Veras Melanie , Guzmán Lazala Teresa Del Carmen , Sánchez-Vincitore Laura Virginia 
Published: May 2022

Este estudio tiene la finalidad de analizar la sintomatología ansiosa de 239 estudiantes en universidades de República Dominicana durante el cierre de las instituciones educativas por la pandemia de COVID-19 en el mes de octubre de 2020. Se utilizó un cuestionario sociodemográfico y la adaptación española del Inventario de Ansiedad de Beck. Esta investigación es de tipo cuantitativo, transversal y con un alcance descriptivo-correlacional. Se reclutó a los participantes a través de un muestreo por bola de nieve. Se analizaron los datos con el fin de estudiar diferencias por sexo, carrera y edad. Se encontraron niveles de ansiedad de moderados a altos en la muestra estudiada. Los hallazgos fueron significativos para los síntomas de ansiedad, diferenciados por sexo, y no se encontraron correlaciones estadísticamente significativas entre sintomatología ansiosa y edad. Con base en estos descubrimientos, se enuncian algunas medidas que pueden ser implementadas por las autoridades institucionales orientadas a estudiantes universitarios.
La Aplicación de las Técnicas de Programación Neurolingüística para Aumentar la Motivación Estudiantil en la Educación de Adultos
Authors: Ruiz Santiago Silvia 
Published: May 2022

La pérdida motivacional estudiantil es un hecho que enfrentan hoy día los sistemas educativos a nivel mundial. Conocer cómo los líderes educacionales pueden ayudar a los educandos a activar su interés mediante la instrucción será esencial. El objetivo residirá en conocer cómo funciona el sistema neurológico, lingüístico y cómo se programan los pensamientos, para realizar una reestructuración cognitiva en el estudiante, logrando mejorar su motivación y, por ende, alcanzar tanto los objetivos estudiantiles, de los docentes como los institucionales. Por lo tanto, la programación neurolingüística en el aprendizaje de una segunda lengua en la población de adultos va a permitir a través de sus técnicas ayudar al alumno en el proceso instructivo lingüístico, consiguiendo consecuentemente su motivación. Se concluye con la importancia de la puesta en práctica de la programación neurolingüística, así como de sus técnicas con el fin de conseguir el éxito estudiantil.
Formación docente en Ciencia y Tecnología desde un escenario alternativo de educación
Authors: Ariza-Porras Angie Paola , Franco-Avellaneda Manuel , Quiroga-Monroy Jesus David 
Published: May 2022

El potencial de la ciudad como entorno y agente educativo es reconocido cada vez con más fuerza en las agendas de las políticas públicas. Este artículo explora la manera en la que las ciencias pueden ofrecer herramientas para apropiar la ciudad de forma más equitativa y participativa e imaginar en ella nuevas posibilidades, reconociendo el rol protagónico que tienen en esta tarea los y las docentes. Para esto se exponen los aprendizajes de la Ruta de Formación en Ciencia y Tecnología, un programa de formación docente realizado por el museo interactivo Maloka y la Secretaría de Educación de Bogotá, durante el año 2019.