bluuebunny/crossref_metadata_2025_split huggingface dataset:
GC-MS Profile of Hua-Feng-Dan and RNA-Seq Analysis of Induced Adaptive Responses in the Liver
Authors: Liu Jia-Jia , Liang Yan , Zhang Ya , Wu Rui-Xia , Song Ying-Lian , Zhang Feng , Shi Jing-Shan , Liu Jie , Xu Shang-Fu , Wang Zhang 
Published: March 2022

Background: Hua-Feng-Dan is a patent Chinese medicine for stroke recovery and various diseases. This study used GC-MS to profile its ingredients and RNA-Seq to analyze the induced adaptive response in the liver.Methods: Hua-Feng-Dan was subjected to steam distillation and solvent extraction, followed by GC-MS analysis. Mice were orally administered Hua-Feng-Dan and its “Guide drug” Yaomu for 7 days. Liver pathology was examined, and total RNA isolated for RNA-Seq, followed by bioinformatic analysis and quantitative real-time PCR (qPCR).Results: Forty-four volatile and fifty liposoluble components in Hua-Feng-Dan were profiled and analyzed by the NIST library and their concentrations quantified. The major components (&gt;1%) in volatile (5) and liposoluble (10) were highlighted. Hua-Feng-Dan and Yaomu at hepatoprotective doses did not produce liver toxicity as evidenced by histopathology and serum enzyme activities. GO Enrichment revealed that Hua-Feng-Dan affected lipid homeostasis, protein folding, and cell adhesion. KEGG showed activated cholesterol metabolism, bile secretion, and PPAR signaling pathways. Differentially expressed genes (DEGs) were identified by DESeq2 with p &lt; 0.05 compared to controls. Hua-Feng-Dan produced more DEGs than Yaomu. qPCR on selected genes largely verified RNA-Seq results. Ingenuity Pathways Analysis of the upstream regulator revealed activation of MAPK and adaptive responses by Hua-Feng-Dan, and Yaomu was less effective. Hua-Feng-Dan-induced DEGs were highly correlated with the Gene Expression Omnibus database of chemical-induced adaptive transcriptome changes in the liver.Conclusion: GC-MS primarily profiled volatile and liposoluble components in Hua-Feng-Dan. Hua-Feng-Dan at the hepatoprotective dose did not produce liver pathological changes but induced metabolic and signaling pathway activations. The effects of Hua-Feng-Dan on liver transcriptome changes point toward induced adaptive responses to program the liver to produce hepatoprotective effects.
GLP-1 Receptor Agonists and Coronary Arteries: From Mechanisms to Events
Authors: Pahud de Mortanges Aurélie , Sinaci Eldem , Salvador Dante , Bally Lia , Muka Taulant , Wilhelm Matthias , Bano Arjola 
Published: March 2022

Objective: Glucagon-like peptide 1 receptor agonists (GLP-1 RAs) lower plasma glucose through effects on insulin and glucagon secretion and by decelerating gastric emptying. GLP-1 RAs have many beneficial effects beyond glycemic control, including a protective role on the cardiovascular system. However, underlying mechanisms linking GLP-1 RAs with coronary artery disease are complex and not fully elucidated. In this mini-review, we discuss these mechanisms and subsequent clinical events.Data Sources: We searched PubMed and Google Scholar for evidence on GLP-1 RAs and coronary events. We did not apply restrictions on article type. We reviewed publications for clinical relevance.Synopsis of Content: In the first part, we review the current evidence concerning the role of GLP-1 RAs on potential mechanisms underlying the development of coronary events. Specifically, we discuss the role of GLP-1 RAs on atherosclerosis and vasospasms of epicardial coronary arteries, as well as structural/functional changes of coronary microvasculature. In the second part, we summarize the clinical evidence on the impact of GLP-1 RAs in the prevention of acute and chronic coronary syndromes and coronary revascularization. We conclude by discussing existing gaps in the literature and proposing directions for future research.
The Function of Metformin in Aging-Related Musculoskeletal Disorders
Authors: Song Yanhong , Wu Ziyi , Zhao Ping 
Published: March 2022

Metformin is a widely accepted first-line hypoglycemic agent in current clinical practice, and it has been applied to the clinic for more than 60 years. Recently, researchers have identified that metformin not only has an efficient capacity to lower glucose but also exerts anti-aging effects by regulating intracellular signaling molecules. With the accelerating aging process and mankind’s desire for a long and healthy life, studies on aging have witnessed an unprecedented boom. Osteoporosis, sarcopenia, degenerative osteoarthropathy, and frailty are age-related diseases of the musculoskeletal system. The decline in motor function is a problem that many elderly people have to face, and in serious cases, they may even fail to self-care, and their quality of life will be seriously reduced. Therefore, exploring potential treatments to effectively prevent or delay the progression of aging-related diseases is essential to promote healthy aging. In this review, we first briefly describe the origin of metformin and the aging of the movement system, and next review the evidence associated with its ability to extend lifespan. Furthermore, we discuss the mechanisms related to the modulation of aging in the musculoskeletal system by metformin, mainly its contribution to bone homeostasis, muscle aging, and joint degeneration. Finally, we analyze the protective benefits of metformin in aging-related diseases of the musculoskeletal system.
Implementation of a Spatially-Variant and Tissue-Dependent Positron Range Correction for PET/CT Imaging
Authors: Kertész Hunor , Beyer Thomas , Panin Vladimir , Jentzen Walter , Cal-Gonzalez Jacobo , Berger Alexander , Papp Laszlo , Kench Peter L. , Bharkhada Deepak , Cabello Jorge , Conti Maurizio , Rausch Ivo 
Published: March 2022

AimTo develop and evaluate a new approach for spatially variant and tissue-dependent positron range (PR) correction (PRC) during the iterative PET image reconstruction.Materials and MethodsThe PR distributions of three radionuclides (18F, 68Ga, and 124I) were simulated using the GATE (GEANT4) framework in different material compositions (lung, water, and bone). For every radionuclide, the uniform PR kernel was created by mapping the simulated 3D PR point cloud to a 3D matrix with its size defined by the maximum PR in lung (18F) or water (68Ga and 124I) and the PET voxel size. The spatially variant kernels were composed from the uniform PR kernels by analyzing the material composition of the surrounding medium for each voxel before implementation as tissue-dependent, point-spread functions into the iterative image reconstruction. The proposed PRC method was evaluated using the NEMA image quality phantom (18F, 68Ga, and 124I); two unique PR phantoms were scanned and evaluated following OSEM reconstruction with and without PRC using different metrics, such as contrast recovery, contrast-to-noise ratio, image noise and the resolution evaluated in terms of full width at half maximum (FWHM).ResultsThe effect of PRC on 18F-imaging was negligible. In contrast, PRC improved image contrast for the 10-mm sphere of the NEMA image quality phantom filled with 68Ga and 124I by 33 and 24%, respectively. While the effect of PRC was less noticeable for the larger spheres, contrast recovery still improved by 5%. The spatial resolution was improved by 26% for 124I (FWHM of 4.9 vs. 3.7 mm).ConclusionFor high energy positron-emitting radionuclides, the proposed PRC method helped recover image contrast with reduced noise levels and with improved spatial resolution. As such, the PRC approach proposed here can help improve the quality of PET data in clinical practice and research.
Meta-Analysis of the Factors Influencing the Restoration of Spontaneous Circulation After Cardiopulmonary Resuscitation
Authors: An Hui-Ru , Han Yi-Ran , Wang Tian-Hao , Chi Fei , Meng Yu , Zhang Chun-Yan , Liang Jian-Qin , Li Xiang-Lan 
Published: March 2022

ObjectiveThis study aimed to systematically evaluate the factors influencing the restoration of spontaneous circulation (ROSC) after cardiopulmonary arrest (CA).MethodsRelevant papers on the factors influencing the ROSC in patients with CA were retrieved from PubMed, Embase, Cochrane Library, China Biology Medicine disk, China National Knowledge Infrastructure, Wanfang, and VIP databases. After screening, data extraction, and quality evaluation of the papers, a meta-analysis was carried out.ResultsA total of 36 papers, involving a total sample size of 2,305 cases, were included. The meta-analysis revealed that the location and time of onset of CA, the type of cardiac rhythm at first monitoring, the start time of cardiopulmonary resuscitation (CPR), the use of electric defibrillation, and the cumulative dose of adrenaline all significantly impacted the ROSC (p &lt; 0.05) and may have affected its success rate. The pH value at CA onset, combined use of adrenaline and vasopressin, CPR duration, mechanical cardiac compression use, and whether CA was caused by heart disease had no significant effect on ROSC.ConclusionThe location and time of onset of CA, the cardiac rhythm at first monitoring, the start time of CPR, the use of electric defibrillation, and the cumulative dose of adrenaline significantly impacted the ROSC.
Acceptability of Peer Support for People With Schizophrenia in Chennai, India: A Cross Sectional Study Amongst People With Lived Experience, Caregivers, and Mental Health Professionals
Authors: Sims Sonia , Hepsipa Omega Juliet S. , Joseph Jainey , Gopal Subhashini , Raghavan Vijaya , Venkatraman Lakshmi , Padmavati Ramachandran 
Published: March 2022

IntroductionEstablishing structured peer support in mental health, particularly for people with schizophrenia, as a psychosocial intervention is early in low and middle-income countries like India. Before implementing and understanding the effectiveness of peer support service and which mode of peer support delivery will be suitable for our culture, our study aimed to understand if peer support would be accepted by the different participants like persons with schizophrenia, caregivers and mental health professionals in a tertiary care center in Chennai, India.MethodsThe study was conducted at the outpatient department (OPD) of a tertiary psychiatric care facility in Chennai, India. A cross-sectional study method was used. Consecutive persons diagnosed with schizophrenia and caregivers of persons with schizophrenia, who attended the outpatient department, and mental health professionals within and outside the facility who met the inclusion and exclusion criteria participated in the study. A structured questionnaire purposefully developed for the study was administered to the different study participants. Descriptive statistics were used to analyze the data. Categorical variables were expressed as frequency and percentages, while the continuous variables were expressed as mean and standard deviation.ResultsA total of 155 participants (52 persons with schizophrenia, 50 caregivers and 53 mental health professionals) completed the survey. The majority of the participants (90.4% of persons with schizophrenia, 86% caregivers and all mental health professionals) welcomed peer support interventions. The participants wanted peers to help persons with schizophrenia achieve personal goals to enhance their mental health and day to day living with an emphasis on independent living and interpersonal and social relationships and help them achieve medication and treatment-related goals toward recovery. Understanding the role of a peer support volunteer and transitioning from a “person with schizophrenia” to a “peer support volunteer” by persons with schizophrenia was thought most challenging.ConclusionThe results highlight the potential acceptability of peer support across several stakeholders in the care of schizophrenia in a low and middle-income country context. The results may guide the implementation of a peer support volunteer programme as an essential mechanism of delivering psychosocial interventions for persons with schizophrenia.
Thoracic Outlet Syndrome: Single Center Experience on Robotic Assisted First Rib Resection and Literature Review
Authors: Gkikas Andreas , Lampridis Savvas , Patrini Davide , Kestenholz Peter B. , Azenha Luis Filipe , Kocher Gregor Jan , Scarci Marco , Minervini Fabrizio 
Published: March 2022

BackgroundThoracic outlet syndrome (TOS) is a pathological condition caused by a narrowing between the clavicle and first rib leading to a compression of the neurovascular bundle to the upper extremity. The incidence of TOS is probably nowadays underestimated because the diagnosis could be very challenging without a thorough clinical examination along with appropriate clinical testing. Beside traditional supra-, infraclavicular or transaxillary approaches, the robotic assisted first rib resection has been gaining importance in the last few years.MethodsWe conducted a retrospective cohort analysis of all patients who underwent robotic assisted first rib resection due to TOS at Lucerne Cantonal Hospital and then we performed a narrative review of the English literature using PubMed, Cochrane Database of Systematic Reviews and Scopus.ResultsBetween June 2020 and November 2021, eleven robotic assisted first rib resections were performed due to TOS at Lucerne Cantonal Hospital. Median length of stay was 2 days (Standard Deviation: +/– 0.67 days). Median surgery time was 180 min (Standard Deviation: +/– 36.5). No intra-operative complications were reported.ConclusionsRobotic assisted first rib resection could represent a safe and feasible option in expert hands for the treatment of thoracic outlet syndrome.
Excel como estrategia de enseñanza-aprendizaje de los estados financieros en la especialidad de Contabilidad
Authors: Jáuregui Campos Violeta Silvia , Polar Cepeda Javier Felipe , Diaz Centeno Laura Violeta 
Published: March 2022

En la formación de los estudiantes de Contabilidad es necesario incluir la enseñanza de herramientas tecnológicas que contribuyan a mejorar sus competencias las cuales determinaran la calidad en su desempeño profesional como es el uso del Excel. El objetivo de este estudio fue determinar la efectividad del programa Excel para la presentación de estados financieros en estudiantes de contabilidad. La metodología fue evaluativa con enfoque cuantitativo, de tipo aplicada con diseño cuasi experimental, porque se aplicó un programa sobre el uso de Excel, a una muestra de cuarenta estudiantes pertenecientes a V ciclo de un instituto de educación superior. Los resultados demostraron que el 62,5 % de los estudiantes se ubicaron en el nivel de logro destacado. Se concluyó que, uso del programa Excel es efectivo para la enseñanza de estados financieros en estudiantes de contabilidad.
PERSEPSI MAHASISWA AKUNTANSI NON MUSLIM TERHADAP AKUNTANSI SYARIAH
Authors: Siti Nur Anisa  , Jurana  , Muh. Darma Halwi  , Abdul Kahar  , Muhammad Ilham Pakawaru  , Masruddin  
Published: March 2022

This study aims to determine the perception of non-Muslim accounting students regarding Islamic accounting. The transcendental phenomenology approach was chosen as the research approach. Researchers collected data by conducting in-depth interviews and observations of undergraduate students majoring in non-Muslim accounting in Palu City. The results of the study show that each informant has a different understanding of Islamic Accounting, this is due to a lack of understanding of the terms in Islamic Accounting, disinterest in Islamic Accounting courses due to differences in religion. The implications of research as input for academics in teaching are not just transfer knowledge, but the main thing is transfer values because it is a means of preaching and it is the responsibility of academics not to separate religious values from accounting science.
Abstrak
Penelitian ini bertujuan untuk mengetahui persepsi mahasiswa akuntansi non muslim mengenai akuntansi Syariah. Pendekatan fenomenologi transcendental dipilih sebagai pendekatan penelitian. Peneliti mengumpulkan data dengan melakukan wawancara mendalam dan observasi terhadap mahasiswa S1 jurusan akuntansi non muslim di Kota Palu. Hasil dari penelitian menunjukan bahwa masing-masing informan memiliki pemahaman berbeda mengenai Akuntansi Syariah, hal ini dikarenakan kurangnya pemahaman mengenai istilah dalam Akuntansi Syariah, ketidaktertarikan terhadap mata kuliah Akuntansi Syariah akibat perbedaan agama yang dianut. Implikasi penelitian sebagai masukan akademisi dalam mengajar bukan sekedar transfer knowledge, tetapi yang utama adalah transfer value karena merupakan sarana dakwah dan tanggung jawab akademisi untuk tidak memisahkan nilai agama dari keilmuan akuntansi.
Relationship between Competence, Motivation, and Leadership with Performance of Nutrition Workers at Public Health Centers
Authors: Manumpil Meiny O. , Kapantow Nova H. , Kaseke Martha M. 
Published: March 2022

Abstract: Achieving good performance needs to be supported by qualified human resources. Factors that affect performance include competence, motivation, and leadership. This study aimed to determine the relationship between competence, motivation, and leadership with the performance of health workers at public health center. This was a quantitative study. The population consisted of all nutrition workers at public health centers in Manado totaling 48 people; all of them were samples of this study. Data were analyzed by using the Pearson product moment test and the multiple linear regression test. The results showed that the mean of competence variable was 19.69; of motivation variable was 103.2; of leadership variable was 44.19; and of performance variable was 103.02. The Pearson product moment test resulted in p=0.020 for the correlation between competence and performance; p=0.012, for the correlation between motivation and performance; and p=0.200, for the correlation between leadership and performance. The multiple linear regression test showed that motivation had the strongest relationship with performance (p=0,018). In conclusion, there are significant relationships between competence and motivation with performance. Motivation has the strongest relationshipwith performance.Keywords: competence; motivation; leadership; performanceAbstrak: Pencapaian kinerja yang baik perlu didukung oleh sumber daya manusia yang berkualitas. Faktor yang memengaruhi kinerja di antaranya faktor kepemimpinan, faktor pribadi meliputi motivasi, disiplin, keterampilan, faktor sistem, dan faktor situasional atau lingkungan kerja. Penelitian ini bertujuan untuk mengetahui hubungan antara kompetensi, motivasi, dan kepemimpinan dengan kinerja petugas gizi di puskesmas. Jenis penelitian ialah kuantitatif.Populasi ialah seluruh petugas gizi di puskesmas Kota Manado.berjumlah 48 orang dengan populasi total sebagai sampel. Analisis statistik yang digunakan ialah uji Pearson product moment dan uji regresi linier berganda. Hasil penelitian mendapatkan rerata kompetensi 19,69, rerata motivasi 103,2, rerata kepemimpinan 44,19, dan rerata kinerja 103,02. Hasil uji Pearson productmoment menunjukkan nilai p=0,020 untuk korelasi antara kompetensi dengan kinerja; p=0,012 untuk korelasi antara motivasi dengan kinerja; dan p=0,200 untuk korelasi antara kepemimpinan dengan kinerja. Hasil uji regresi linier berganda menunjukkan bahwa variabel motivasi yang paling erat hubungannya dengan kinerja. Simpulan penelitian ini ialah terdapat hubungan bermakna antara kompetensi dan motivasi dengan kinerja petugas gizi di puskesmas. Mottivasi memiliki hubungan yang paling erat dengan kinerja.Kata kunci: kompetensi; motivasi; kepemimpinan; kinerja
Urgensi Nilai-Nilai Bisnis Syariah Pada Program Dana Bergulir APBD D.I Yogyakarta
Authors: Fauzi Yayan 
Published: March 2022

Dana Bergulir APBD D.I Yogyakarta adalah yang pemerintah Yogyakarta yang di salurkan kepada Koperasi atau BMT untuk menstimulus pengembangan dan perkuatan permodalan BMT (Baitul Maal Wattamwil) di daerah Yogyakarta melalui dinas koperasi dan UMKM. Hal ini sesuai dengan Peraturan Menteri Keuangan no 218/ PMK.05/2009 bahwa Dana Bergulir adalah dana yang dialokasikan oleh kementerian Negara/lembaga/ satuan kerja badan layanan umum untuk kegiatan perkuatan modal usaha bagi koperasi, usaha mikro, kecil, menengah, dan usaha lainnya yang berada dibawah binaan kementerian Negara/ lembaga.
BMT (Baitul Maal Wattamwil) atau dikenal juga dengan nama Koperasi Simpan Pinjam dan Pembiayaan Syariah (KSPPS) merupakan salah satu bisnis lembaga keuangan syariah yang dimana prinip operasionalnya berdasarkan syariah yaitu Al-Quran dan Al-Hadis. Dalam bisnis syariah penting untuk menjalankan nilai-nilai syariah yang memuat 5 (lima) nilai yaitu Nilai Kepemilikan, Nilai Keadilan, Nilai Keseimbangan, Nilai Kebebasan dan Nilai Keberagaman, sehingga lembaga keuangan syariah tidak menyimpang dari nilai-nilai syariah itu sendiri.
Dikala semakin berkembangnya bisnis syariah, yang dari tahun ketahun semakin meningkat, maka semakin banyak juga BMT atau KSPPS yang mendapatkan program pembiayaan dari pemerintah, salah satunya adalah program dana bergulir APBD D.I Yogyakarta. Di mulai dari tahun 2008 yang mendapatkan program dana bergulir hanya 1 BMT dari total 18 koperasi tetapi di program dana bergulir tahun 2016 dan 2017 ada 22 BMT dari total 31 dan 39 koperasi yang mendapatkan dana bergulir APBD D.I Yogyakarta, hal ini menunjukan kinerja dan pertumbuhan BMT yang baik.
Dengan kinerja dan pertumbuhan yang baik oleh BMT ada sebagian BMT/ KSPPS yang masih meragukan kesyariahan dari program dana bergulir APBD D.I Yogyakarta ini, sehingga perlu kiranya melihat nilai-nilai yang ada dalam dana bergulir ini secara syariah.
Dengan melihat uraian diatas, dalam jurnal ini akan di bahas bagaimana Urgensi Nilai-Nilai Bisnis Syariah Pada Program Dana Bergulir APBD D.I Yogyakarta.
Larangan Perkawinan Bulan Tuwun Ditinjau Menurut Maqashid Syariah
Authors: Mustafid Mustafid 
Published: March 2022

Di desa Sibiruang memiliki adat istiadat yang masih ditaati sampai saat sekarang, larangan perkawinan ketika bulan tuwun adalah salah satu adat istiadat yang masih di pertahankan oleh masyarakat hingga saat ini. Penelitian ini bertujuan untuk memahami larangan perkawinan ketika bulam tuwun dengan melihat dari sudut pandang Maqashid Syariah. Adat istiadat sangat menarik untuk diteliti karena akan selalu mengalami perkembangan atau perubahan dengan berubahnya waktu, begitu juga dengan hukum Islam akan bisa berubah dengan seiring berubahnya masa. Tulisan ini berupaya untuk mencari bagaimana pandangan Maqashid Syariah terhadap larangan perkawinan ketika bulan tuwun, dengan menggunakan pendekatan deskriptif kualitatif dengan mengemukakan tradisi larangan perkawinan ketika bulan tuwun. Hasil yang ditemukan bahwa agama Islam betujuan untuk menjaga keturunan (Hifdz Nasab) dan cara menjaganya adalah dengan perkawinan. Adanya larangan perkawinan ketika bulan tuwun membuat waktu diperbolehkan untuk menikah menjadi sempit, sehingga kemashalatan umat tidak didapatkan, pada dasarnya tidaklah dilarang untuk menikah pada waktu itu, kemudian ditakutkan juga ketika ada larangan seperti itu akan membuat pasangan yang akan menikah melakukan sesuatu yang senonoh karena tidak diperbolehkan menikah, atas dasar inilah larangan perkawinan ketika bulan tuwun tidaklah sesuai dengan Maqashid Syariah yang menginginkan kemashalatan umat.