bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessment of the Sofosbuvir + Daclatasvir (±) Ribavirin Treatment and the Prognostic Efficacy of Interferon-gamma Induced Protein 10, Macrophage Inflammatory-1-Beta, and C-reactive Protein in Hepatitis C Egyptian Patients' Therapy Outcome
Authors: Ibrahim Hany Mohammed , Abdel-Ghaffar Faten Roshdy , Zied Ahmed Bahgat , El-Ghareeb Sameha Husni 
Published: July 2022

Background:
Hepatitis C virus (HCV) is the most important virus among the infectious agents as the cause of liver disease in Egypt. The aim of this work was to assess the efficacy and tolerability of the sofosbuvir + daclatasvir (±) ribavirin (SOF + DCV [±] RBV) regimens and to evaluate the association of interferon-gamma induced protein 10 (IP-10) and macrophage inflammatory-1-beta (MIP-1β) and C-reactive protein (CRP) with treatment responses as potential biomarkers for the prognosis of HCV in patients from Kafer EL-Sheikh Province, Egypt.

Methods:
HCV Patients were treated with a combined treatment of SOF plus DCV with or without RBV for 12 weeks. The biochemical, hematological parameters, HCV RNA load, IP-10, MIP-1β, and CRP were detected pre- and post-treatment.

Results:
Both SOF-based regimens improved the liver function, anemia, leukopenia, and thrombocytopenia especially after treatment with SOF, DCV, and RBV. Sustained virological response 12 was slightly higher in the group receiving (SOF and DCV) therapy (99.42%) when compared to (SOF, DCV, and RBV) therapy (98.44%). The most common adverse events were fatigue, headache, anorexia, rash, and nausea. Interestingly, higher levels of the IP-10, MIP-1β, or CRP were observed in the serum of patients with HCV before treatment, and their levels significantly decreased after the treatment of both regimens.

Conclusions:
Our study revealed that SOF-based regimens are efficacious in controlling the HCV load and IP-10, MIP-1β, or CRP have both bioprognostic efficacy and potential role in predicting treatment responses.
A simple screening program for oral cancer in a defined geographic area in southern India
Authors: Madankumar Parangimalai D. , Iyer Kiran , Soni Suganya , Nagarajan Lavanya , Kumar Kaliyaperumal , Solomon Samuel , Seshadri Mandalam S. , Aswath Narayanan Mani Bagyalakshmi , Ranganathan Kannan 
Published: July 2022

Background:
Community-level surveys of potentially malignant and malignant oral lesions are helpful to accurately determine the prevalence and aid in planning population-based strategies for oral cancer prevention.

Objectives:
We aimed to assess the disease burden through a systematic oral cancer screening program in a defined semi-urban population in Ranipet district (Tamil Nadu, India).

Materials and Methods:
A multiphase community-based screening program was conducted by the Ragas Dental College and Hospital, Chennai, India, in partnership with Thirumalai Mission Trust Hospital in Ranipet district (Tamil Nadu, India) in a zone-wise manner from Aug 1, 2018 to Dec 31, 2019. Phase I consisted of screening of those who fulfilled the eligibility criteria; demographic data were collected by trained dentists, following which toluidine blue staining of suspected potentially malignant lesions was done. Subjects whose oral lesions stained positive were referred to a hospital where the staining procedure was repeated for confirmation, and then biopsy was done for all subjects by a trained dentist. The subjects were followed up, and appropriate referrals were initiated for all the subjects based on their diagnosis. Descriptive statistics were used to analyze the distribution of potentially malignant cases. Sensitivity, specificity, and predictive values were calculated for the clinical diagnosis using the histopathologic diagnosis as the gold standard.

Results:
A total of 1389 tobacco users (1012 [72.9%] men) and 3140 non-tobacco users were evaluated. Among them, 194 (14%) demonstrated clinical abnormalities in their oral mucosa; 157 required follow-up and were referred. Of the 157 referrals, 140 (89.2%) went for follow-up, and 84 (64%) of them required biopsies. Of the 74 eligible biopsies examined (7 dropped out and 3 biopsies were rejected due to inadequate tissue), 1 had definite malignancy (1.4%), 41 (55.4%) had potentially malignant oral disorders, and 32 (43.2%) had non-specific features. The overall sensitivity, specificity, positive predictive value, and negative predictive value for the clinical diagnosis made at the screening program were 88%, 25%, 61%, and 61%, respectively.

Conclusion:
Systematic visual oral screening restricted to high-risk individuals is a worthwhile initiative for the detection and control of oral cancer. Visual screening and early detection of premalignant oral disorders has the potential for early detection of potentially malignant and malignant oral lesions, and thus could play a pivotal role in disease control and improving patient outcomes. (Partial funding provided by the University Research Committee, The TN Dr. MGR Medical University, Guindy, Chennai; and the Thirumalai Charitable Trust, Ranipet, India)
Common Hepatitis B Virus Genotypes among Blood Donors in Lagos, Nigeria
Authors: Uche Ebele I. , Chukwukaodinaka Nwakaego E. , Akinbami Akinsegun A. , Adeyemi Oluwatosin I. , Hassan Aderonke O. , Bamiro Rafah A. , Ibrahim Ismaila Nda , Suleiman Aisha M. , Augustine Benjamin , Anaduaka Doris Chinyelu 
Published: July 2022

Background:
Hepatitis B virus (HBV) infection is one of the public health diseases causing global health problems. It is a leading cause of cirrhosis and hepatocellular carcinoma. Blood transfusion is a major route of its transmission and screening of blood is suboptimal in our environment. Occult HBV infection describes the presence of HBV DNA in blood or liver tissue in patients who are hepatitis B surface antigen (HBsAg) seronegative. This study documented the common genotypes of HBV a blood-borne infection in the population of blood donors in Lagos.

Methods:
This was a cross-sectional study carried out at the blood donor clinics of ten Lagos State Government-owned hospitals in Lagos State. A total of 1400 participants were recruited consecutively from November 2020 to June 2021. All participants' samples were screened using Diaspot Rapid Test Kit (RTK) and Dialabenzyme enzyme-linked immunosorbent assay (ELISA) kit. Furthermore, some of the plasma samples were used for HBV DNA extraction and genotyping using the real time-polymerase chain reaction. Statistical analysis was carried out using the Statistical Package for the Social Sciences (SPSS) software version 26 and P value was considered significant at ≤0.05.

Results:
The sero-prevalence of HBsAg using RTK and ELISA was 19.9% and 22.4%, respectively. The prevalence of occult HBV infection was 5.2%. A total of 278 and 313 HBsAg RTK and ELISA positive samples were obtained, respectively. HBV genotype result had A (46.6%) as the most prevalent followed closely by B (44.7%), E (23.8%), D (20.9%) and C (11.2%).

Conclusion:
HBV infection has a high prevalence among blood donors. ELISA is a more sensitive screening tool and its use should be advocated nationally. HBV genotype A is the most prevalent genotype from our study.
Effect of humic acid on the growth of seedling tomato (Solanum lycopersicum) and melon Cucumis melo)
Authors: Dunoyer Arnulfo Antonio Tarón , Castillo Fredy Colpas , Camargo Jairo Mercado 
Published: July 2022

This study evaluated the effect of HS extracted from mineral coal on the growth of tomato (Solanum lycopersicum) and melon (Cucumis melo) plants to determine the role that humic substances (HS) play as promoters of plant growth. Three concentrations of HS were evaluated in 200 grams of soil. The fertilizer (urea 0.3%) and humic acid in concentrations of 0.05%, 0.1%, and 0.2% were added directly and at the same time to the amount of soil, using a control sample without the addition of humic acid. Increase measurements were made at three-day intervals up to 45 days. Plants treated with high concentrations of HS demonstrated a significant increase in roots (p>0.05). In both plants, the concentration of 0.2% in HS showed the greatest increase in growth, with the melon plant showing the greatest variation as time passed, with its highest peak in 36 days (13.1 ± 0.05cm) of the experiment, while in the tomato plant the maximum growth occurred in 30 days (9.2 ± 0.01 cm). The Dunnett test showed that there was no statistically significant difference between the control and the concentrations of 0.05% and 0.1% (p>0.05), while among the control and the soil sample with a concentration of 0.2% there was a statistically significant difference (p<0.05). The results show a notable influence of humic acid on the growth of the studied plants, especially at high concentrations.
Keywords: fertilizer, horticulture, humic acid, soils.
Limited Awareness of Melioidosis in High-risk Populations Despite an Increasing Incidence of the Disease in Far North Queensland, Australia
Authors: Smith Simon , Buikstra Elizabeth , Rubenach Sally , Preston-Thomas Annie , Hanson Josh 
Published: July 2022

ABSTRACT.
The incidence of melioidosis, an opportunistic infection caused by Burkholderia pseudomallei, has recently doubled in Far North Queensland (FNQ), Australia. This contrasts with the local burden of dengue, which is nearing elimination, and the stable incidence of leptospirosis. This questionnaire-based study assessed the awareness of melioidosis among people in FNQ with risk factors for the disease, using awareness of leptospirosis and dengue as comparators. There were 427 respondents; 361 (85%) reported one or more risk factors for melioidosis. Only 69 of 361 (19%) had heard of melioidosis compared with 301 of 361 (83%) who had heard of dengue (P < 0.001) and 137 of 361 (38%) who had heard of leptospirosis (P < 0.001). In FNQ, Australia, there is an increasing local incidence of melioidosis, but there is limited awareness of the disease among high-risk individuals. Greater community awareness of melioidosis is necessary to implement strategies to prevent disease and expedite the presentation of patients with this life-threatening infection.
SOLUSI AL-QUR’AN DALAM MEMBANGUN MASYARAKAT ANTI KORUPSI
Authors: Ardli Muhammad Nabat 
Published: July 2022

Tindak kejahatan korupsi di Indonesia selalu ada kasus baru yang muncul di berita media, hal ini menunjukkan bahwa korupsi tidak akan ada habisnya selama ada manusia dimuka bumi. Penanggulangan dan pencegahan sudah dilakukan dengan berbagai metode, namun hasilnya masih sangat jauh dari kata berhasil. Masyarakat Indonesia yang mayoritas beragama Islam diharapkan dapat membendung budaya korupsi ini lewat pendekatan rohani, pendekatan rohani dinilai dapat mendorong manusia untuk menjauhi kedzaliman terhadap diri sendiri maupun orang lain termasuk kesadaran anti korupsi. Metodepenelitian makalah ini adalah pendekatan kualitatif adapun jenis penelitiannya adalah library research yaitu data yang dihimpun berasal dari buku, jurnal dan lainnya. Makalah ini membahas bagaimana ayat-ayat al-Qur’an dapat merasuk kedalam karakter umat Islam dan membangun masyarakat yang berkepribadian baik dan anti terhadap kejahatan korupsi. Hasil dari makalah ini bahwa sarana pendidikan berbasis keislaman dan peran para da’i, muballig dan kyai adalah sebagai pondasi dalam pencegahan tindak pidana korupsi yang terjadi pada masyarakat Indonesia yang mayoritas muslim, dengan peningkatan kesadaran hukum, dan penanaman ajaran agama Islam kepada peserta didik maupun masyarakat. Penanaman nilai keislama khususnya kesadarang anti korupsi perlu digalakkan sejak usia dini agar kedepannya terhindar dari perilaku maupun tindak korupsi
IMPLEMENTASI METODE AMTSILATI UNTUK MENINGKATKAN KEMAMPUAN BACA KITAB KUNING (Studi pada Santri Pondok Pesantren Nurus Salafiyah Kanigaran Kota Probolinggo)
Authors: Rifhan Halili Heri , Adawiyah Roviatul , Prasetiya Benny 
Published: July 2022

Riset ini menyediakan perihal penerapan prosedur Amtsilati guna menaikkan keahlian baca kitab kuning di Pondok Pesantren Nurus Salafiyah Kanigaran Kota Probolinggo. Tujuan dari riset ini guna mendefinisikan bagaimana penerapan prosedur Metode Amtsilati untuk meningkatkan keahlian baca kitab kuning di Pondok Pesantren Nurus Salafiyah. Riset ini merupakan riset deskriptif dengan memakai pendekatan kualitatif. Subyek dalam riset kali ini yaitu mencakup daya pengajar, pengelola amtsilati dan peserta didik. Metode pengumpulan informasi yang digunakan adalah wawancara dan dokumentasi. Informasi yang digabungkan dianalisis melalui beberapa tahapan: display informasi, reduksi informasi dan pengumpulan kesimpulan. Hasil dari riset ini membuktikan bahwa aplikasi tatacara metode amtsilati di pondok pesantren Nurus Salafiyah sanggup meningkatkan keahlian membaca kitab kuning. Aplikasi tatacara metode Amtsilati sudah sesuai dengan penerpannya, cuma saja ada sedikit perbandingan dengan penerapan Amtsilati di pusat Pondok Pesantren Darul Falah, Bangsri, Jepara. Proses pembelajaran dengan metode Amsilati di Pondok Pesantren Nurus Salafiyah terdapat keunikan tersendiri yaitu sebelum masuk santri diwajibkan berbaris dengan membaca qoidah (mengulang mahfuz).
ANALISIS KARAKTER RELIGIUS ANAK DALAM KELUARGA SINGLE PARENT DI KELURAHAN KANIGARAN KOTA PROBOLINGGO
Authors: Khosiah Nur , Cahyaningtias Agustin Tri , Soliha Imro Atus , Firmansyah Firmansyah , Rizqiyah Zahrotur 
Published: July 2022

Keluarga merupakan pondasi dasar yang menopang bagaimana kehidupan anak akan berlangsung. Di dalam keluarga, anak akan mendapatkan suatu pendidikan dari orang tuanya. Akan tetapi tidak dapat dipungkiri adanya sebuah tatanan keluarga yang tidak utuh, yang biasanya kita dengar dengan istilah single parent. Menjadi sosok single parent tentulah tidak menjadi alasan untuk tidak menanamkan ataupun mengajarkan pendidikan karakter pada anak, terlebih karakter religius anak. penulisan ini bertujuan untuk mengetahui bagaimana karakter religius anak dalam keluarga single parent serta untuk mengatahui bagaimana penerapan pendidikan karakter religius yang ada dalam keluarga single parent.penelitian lapangan ini sifatnya kualitatif. Teknik pengumpulan datanya dilaksanakan dengan observasi, wawancara dan dokumentasi. Hasil yang diperoleh dari penelitian yaitu tidak peduli keluarga tersebut keluarga yang utuh ataupun keluarga single parent, keluarga tetaplah menjadi faktor terpenting dari keberhasilan penanaman karakter religius anak. Dengan adanya penerapan penanaman karakter sejak dini, dan adanya pembiasaan ini menjadi pendukung pembentuk karakter anak dalam kehidupan sehari-hari, serta pengarahan pada anak, maka karakter tersebut akan lebih mudah terbentuk dan tertanam dalam diri anak. Khususnya karakter religius anak yang benar-benar membutuhkan proses panjang untuk mendapatkannya.
Modelando os jogos da transição democrática brasileira em busca de seus efeitos nas instituições políticas em vigor
Authors: Corrêa Roberto Ribeiro , Oliveira Dhonny Almeida de 
Published: July 2022

Este artigo analisa a transição democrática brasileira (1974 a 1985), com o objetivo de demonstrar que esse processo se deu de forma contingente, menos na dependência da vontade dos atores do que da interação destes com outros com interesses próprios, em jogos mediados por instituições cambiantes — ou seja, os “jogos de transição contingente”. Com a teoria da escolha racional e os instrumentos da teoria dos jogos, investigo ser a denominação “contingente” adequada para sustentar a hipótese de que evolução incremental das instituições do anunciado processo transicional deu-se condicionada à aleatoriedade de resultados não intencionais procedentes de escolhas intencionais. Os resultados esperados desta investigação, os efeitos sobre o comportamento dos atores no curto, médio e longo prazo, seguem sintetizados nos temas-títulos dos quatro capítulos: esquemas dos jogos da transição democrática brasileira; a convergência e os limites da cooperação mútua; as metáforas da transição democrática ou jogos de um lance aos jogos repetitivos e; ao final, as conclusões onde evidenciamos a precariedade de algumas dimensões do compósito político institucional brasileiro em vigor.
Cultivar Checklist of White Oak Species (EXCLQuercus roburL.)
Authors: McArdle Alice Jacot , Santamour Frank S. 
Published: July 2022

AbstractCultivars of species in the genusQuercus, subgenusQuercus(white oaks, exclud. Q.roburL.) are listed and described. Valid cultivar names are found in only the following species: Q.alba, Q. dentata, Q. frainetto, Q. ilex, Q. macrocarpa, Q. petraea, Q. pubescensandQ. pyrenaica. Invalid names are listed in many of the above-mentioned species as well as inQ. bicolor. A listing of cultivars of white oak hybrids is included.
A contrastive perspective on Moroccan learners’ (in) directness in their interlanguage requests
Authors: Talay Mustapha 
Published: July 2022

This study investigated interlanguage request performance by Moroccan learners of English (MLs) from a contrastive perspective. More specifically, it explored how MLs’ interlanguage requests converged or diverged from English Natives’ (ENs) requests in the use of strategy types and (in) directness. First, a contrastive pragmatic analysis of requests by Moroccan natives (MNs) and ENs is deemed necessary to provide native baseline data and establish MNs’ and ENs’ pragmatic norms of request performance. Second, an interlanguage request analysis is conducted to reveal the pragmatic features of MLs’ requests. The three sets of data for this study were collected via an open questionnaire as it serves the purpose of this investigation. The results revealed that MLs deviated from the ENs’ pragmatic norms of (in) directness, mostly by falling back on their native pragmatic norms, which bears testimony to pragmatic transfer. Requests do not seem to be conceived of in the same way by MNs and ENs, and MLs transferred their native request conception when performing in English. MLs used more direct strategies. The study predicts instances of cross-cultural misunderstanding and pragmatic failure in intercultural encounters between MLs and ENs, which is likely to cause undesirable cross-cultural clichés and stereotypes. The paper suggests some pedagogical implications to alleviate this problem among MLs.
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The Biopic and Beyond
Authors: Piper Melanie 
Published: July 2022

Biopics and other movies and television shows based on real events are increasingly appearing at the multiplex and on streaming platforms alongside blockbuster franchises and adaptations. The appeal of movies and television shows based on true stories is that they claim to tell us what really happened, with the public and private versions of events packaged into one coherent narrative. But how do they do it, and what makes this version of events so appealing?
The Biopic and Beyond investigates the process that turns the distant public figures that populate news and entertainment into screen characters that we can engage with and try to understand a little better. Even though they aren’t the real thing, our engagement with fictionalized versions of public figures can, for better or worse, color the way we understand the real person behind them. Screen engagement with the fake person behind the real person doesn’t only happen in biopics and docudramas, with media as varied as sketch comedy, fan fiction and the celebrity cameo contributing to the ways we understand public figures. Using case studies such as Mark Zuckerberg and The Social Network, Sarah Palin and Saturday Night Live, and Louis C.K. and Louie, The Biopic and Beyond will make you think about the way you see the world through a fictionalized version of it.
PENINGKATAN HASIL BELAJAR SISWA PADA MATERI OPERASI HITUNG BILANGAN BULAT DENGAN MENGGUNAKAN MEDIA PAPAN PERJALANAN
Authors: Yusnita Yusnita 
Published: July 2022

Penelitian ini bertujuan untuk melihat peningkatan hasil belajar siswa kelas IV SD Negeri 16 Bireuen Kabupaten Bireuen pada materi operasi hitung bilangan bulat. Desaian penelitian yang digunakan dalam penelitian ini adalah kualitatif dengan jenis penelitian tindakan kelas (classroom action research). Data yang dikumpulkan dalam penelitian ini adalah hasil tes yang meliputi tes awal dan tes akhir, hasil observasi yang meliputi observasi kegiatan guru dan siswa, serta hasil catatan lapangan. Sumber data dalam penelitian ini adalah siswa kelas IV yang berjumlah 25 orang SD Negeri 16 Bireuen Tahun Ajaran 2020/2021. Data hasil penelitian di analisis dengan menggunakan teknik analisis data kualitatif yang terdiri dan mereduksi data, menyajikan data dan menyimpulkan data. Dari hasil pembelajaran dengan menggunakan media papan perjalanan juga mendapat respon yang baik dari siswa kelas IV SD Negeri 16 Bireuen. Jika ditinjau dari angka ketuntasan yaitu 64 % dan tingkat ketuntasan siswa dalam menguasai materi mencapai 57 % dari nilai rata-rata tingkat ketunrasan 85. Oleh karena itu, hasil yang diperoleh dari pelaksanaan tindakan pada siklus I belum berhasil dan perlu dilakukan siklus berikutnya.dan jika di tinjau dari pelaksanaan siklus II yang tingkat ketuntasan siswa sudah mencapai 92 % . Berdasarkan hasil pelaksanaan penelitian yang telah dilakukan menunjukkan bahwa hasil belajar siswa kelas pada materi operasi penjumlahan bilangan bulat dapat ditingkatkan melalui pelaksanaan kegiatan pembelajaran dengan menggunakan media papan perjalanan di IV SD Negeri 16 Bireuen Kabupaten Bireuen tahun pelajaran 2020/2021.
ANALISIS PELAKSANAAN PEMBELAJARAN MICROTEACHING MAHASISWA PROGRAM STUDI PENDIDIKAN MATEMATIKA UNIVERSITAS ALMUSLIM
Authors: Novianti Novianti , Khaulah Siti 
Published: July 2022

Pelaksanaan pembelajaran microteaching pada mahasiswa bertujuan untuk mengenal bagaimana membuka pelajaran dengan baik,metode pembelajaran yang digunakan, penguasaan kelas, media pembelajaran, keterampilan berkomunikasi dengan para siswa dan keterampilan menutup pembelajaran. Penelitian ini menggunakan penelitian deskriptif kualitatif, Teknik pengumpulan data yang digunakan rubrik penilaian dan lembar observasi keaktifan para mahasiswa saat tampil mengajar didalam kelas. Perhitungan pada rubrik penilaian microteaching dan lembar observasi diperoleh dengan cara menghitung persentase total perolehan skor dari 7 kriteria yang akan dinilai. Berdasarkan 7 kriteria yang akan dinilai pada saat pelaksanaan microteaching adalah kegiatan membuka pelajaran hasil yang diperoleh adalah sebesar 78,89 % dengan predikat baik, strategi/metode dalam mengajar diperoleh nilai sebesar 87,90 dengan predikat sangat baik, Pemahaman konsep dan isi pelajaran sebesar 86,00 dengan predikat sangat baik, indicator media pembelajaran diperoleh nilai sebesar 76,50 % dengan predikat baik, manajemen kelas atau pengelolaan kelas diperoleh nilai sebesar 75,60 % denga predikat baik, indicator keterampilan berbicara diperoleh nilai sebesar 65, 95% dengan predikat cukup dan indicator yang terakhir adalah kegiatan penutup diperoleh nilai sebesar 68,50 % dengan predikat cukup. Dengan demikian kegiatan pembelajaran microteaching yang dilaksanakan oleh mahasiswa Program Studi Pendidikan Matematika Fakultas Keguruan dan Ilmu Pendidikan Universitas Almuslim sudah sangat baik, akan tetapi terdapat dua kriteria yang masih adanya Latihan yang sering dan harus lebih focus, diantarnya adalah pada kriteria keterampilan berbicara dan kegiatan penutup.