bluuebunny/crossref_metadata_2025_split huggingface dataset:
Preconception care utilization and associated factors among reproductive age women in Mizan-Aman town, Bench Sheko zone, Southwest Ethiopia, 2020. A content analysis
Authors: Setegn Alie Melsew , Alemu Tsedach , Alemayehu Dereje , Negesse Yilkal , Gebremariam Abebe 
Published: August 2022

Background
Preconception care is highly important in reducing a number of adverse pregnancy outcomes and helps to improve maternal health. Preconception care optimizes women’s health and improves pregnancy outcomes. It is a cost-effective first-line preventive strategy for birth defects. However, preconception care utilization in Ethiopia was very low. Studies on these issues are limited in Ethiopia in general and in Mizan-Aman town in particular.

Objective
To assess preconception care utilization and associated factors among reproductive age women in Mizan-Aman town, Bench-Sheko Zone, Southwest Ethiopia.

Methods
A community based cross-sectional study design was employed from April 16 to May 26, 2020 in Mizan-Aman town. The total study participants were 624 reproductive age women. Data were collected by using pre-tested interviewer administered questionnaires and entered into Epi-data version 3.1 then exported to STATA version 14 and analyzed accordingly. Univeriate and Bivariable analysis was done by analysis of variance (ANOVA) and independent t-test. Multivariable statistical analysis using generalized linear regression model (GLM) approach was used to classify factors of preconception care utilization. Since our response variable is measured in terms of count variable, we used a Poisson regression model with a log link function. Finally, Statistical significance between dependent and independent variables were assessed by odds ratios and 95% confidence intervals.

Results
Overall, 28.6% of the women receipt atleast one item of preconception care while only 1.5% were taken the whole recommended components of preconception care services. The most common item received in the study area was taking micronutrient supplementation (18.5%). Age of women, educational status, husbands educational status, husbands occupation, wealth status, distance from the health facility, waiting time to get services, planning to pregnancy, age at first pregnancy, previous ANC use, Previous PNC use, adverse pregnancy experience, women’s knowledge of preconception care, and attitude on preconception care were determinants of preconception service utilization.

Conclusions
Preconception care component utilization was lower as compare with recommended service with different disparities. Multipurpose tailored strategies which incorporate a woman with no formal education, poor knwledge on preconception care,never take maternal services previously and distant from health facility could improve preconception care service utilization. Advocative strategies on preconception care component and planning pregnancy may elicite more women to use the services of preconception care.
Prognostic value of SPARC in hepatocellular carcinoma: A systematic review and meta-analysis
Authors: Yang Xiaoyu , Xia Yunhong , Wang Shuomin , Sun Chen 
Published: August 2022

ObjectiveHepatocellular carcinoma (HCC) is characterized by a high degree of malignancy, rapid proliferation of tumor cells, and early liver metastasis. Resistance to multiple drugs independent of the high expression of secreted protein acidic and rich in cysteine (SPARC) is associated with a high risk of recurrence and mortality. However, the prognostic value of SPARC in patients with HCC remains unclear. Therefore, we performed a meta-analysis to evaluate the relationship between the expression of SPARC and the prognosis of patients with HCC.MethodsWe searched for relevant articles in the CNKI, PubMed, EMBASE, and Web of Science databases. The 95% confidence intervals (CIs) were calculated for combined overall survival (OS) and disease-free survival (DFS) to assess the prognostic value of expression of SPARC in patients with HCC.ResultsIn six of the studies, SPARC expression status was significantly associated with OS (combined hazard ratio [HR], 1.38; 95% CI, 1.0–1.82; Z = 2.27, P = 0.02) but not with DFS (combined HR, 0.79; 95% CI, 0.16–4.00, Z = 0.28, P = 0.78). Therefore, it cannot be assumed that upregulated SPARC expression has an effect on DFS in patients with HCC.ConclusionElevated SPARC expression is associated with a low survival rate but not with DFS in patients with HCC. Further studies are needed to confirm our conclusions.RegistrationINPLASY registration number: INPLASY202180115.https://inplasy.com/inplasy-2021-8-0115/.
Elevated risk of acute epiglottitis in patients with chronic obstructive pulmonary disease: A nationwide cohort study
Authors: Huang Shu-Yi , Hsu Cheng-Ming , Yang Yao-Hsu , Tsai Yuan-Hsiung , Tsai Ming-Shao , Chang Geng-He , Liu Chia-Yen , Lee Yi-Chan , Huang Ethan I. , Tsai Yao-Te 
Published: August 2022

Objective
In individuals with epiglottitis, chronic obstructive pulmonary disease (COPD) is a common comorbidity; however, the impact of COPD under such circumstances is not well documented. Therefore, we performed this population-based study to determine whether, in adults, COPD is a risk factor for epiglottitis.

Methods
In this retrospective matched-cohort study, data obtained from the Taiwan National Health Insurance Research Database were analyzed. We identified all patients newly diagnosed as having COPD in 2000–2011 and performed frequency matching and propensity-score matching for every patient with COPD individually to another patient without a COPD diagnosis. We used epiglottitis occurrence as the study endpoint, and we investigated the hazard ratio of epiglottitis by using the Cox proportional hazards model after adjustment for potential confounders.

Results
In the frequency matching, the cumulative epiglottitis incidence was significantly higher (p = 0.005) in the COPD cohort. According to the adjusted Cox proportional hazard model, COPD exhibited a significant association with elevated epiglottitis incidence (adjusted hazard ratio: 1.76; 95% confidence interval: 1.15–2.70, p = 0.009). Similar trend was observed in the propensity-score matching analysis (adjusted hazard ratio: 1.50; 95% confidence interval: 0.99–2.29, p = 0.057). Our subgroup analysis revealed COPD to be an epiglottitis risk factor in male patients and those aged 40–64 years.

Conclusions
This is the first nationwide matched-cohort research to examine the association of COPD with epiglottitis. Our results revealed that COPD may be a potential risk factor for epiglottitis; thus, clinicians should be mindful of the potential increased risk of epiglottitis following COPD.
Calibration methods for flow rates down to 5 nL/min and validation methodology
Authors: Mills Chris , Batista Elsa , Bissig Hugo , Ogheard Florestan , Boudaoud Abir Wissam , Büker Oliver , Stolt Krister , Morgan John , Kartmann Sabrina , Thiemann Kerstin , Miotto Guilherme , Niemann Anders , Klein Stephan , Ratering Gijs , Lötters Joost 
Published: August 2022

Abstract
Improving the accuracy and enabling traceable measurements of volume, flow, and pressure in existing drug delivery devices and in-line sensors operating at very low flow rates is essential in several fields of activities and specially in medical applications. This can only be achieved through the development of new calibrationmethods and by expanding the existing metrological infrastructure to perform micro-flow and nano-flow measurements. In this paper, we will investigate new traceable techniques for measuring flow rate, from 5 nL/min to 1,500 nL/min and present the results of an inter-comparison between nine laboratories for the calibration of two different flow meters and a syringe pump.
On the efficiency of using correlative randomized algorithms for solving problems of gamma radiation transfer in stochastic medium
Authors: Medvedev Ilia N. 
Published: August 2022

Abstract
To solve problems of radiation balance, optical sounding, and tomography, it may be necessary to take into account multiple scattering of radiation in a stochastically inhomogeneous medium. In real radiation models, for this purpose, the numerical-statistical ‘majorant cross-section method’ (MCM, delta-Woodcock tracking) is used based on the alignment of the optical density field by adding an artificial ‘delta scattering’ event. However, the computation cost of the corresponding unbiased estimate of the averaged problem solution infinitely increases as the correlation scale (correlation radius L) of standard mosaic models for a random medium density decreases. Previously, we constructed the MCM randomization providing asymptotically (for L → 0) unbiased estimates of the required functionals, in which the value of the physical attenuation coefficient is randomly chosen at the end of the particle free path l under condition l > L. Otherwise the value of the physical attenuation coefficient is the same as at the starting point of the particle (CR algorithm). In a more accurate functional correlative randomized algorithm (FCR algorithm), the coefficient remains the same with a probability determined by the correlation function. These correlative randomized algorithms were implemented for a mixture of homogeneous substance (water) and a Poisson ensemble of ‘empty’ balls. In the present paper, we construct correlative randomized algorithms for problems related to transfer through a ‘thick’ layer containing a water and a Poisson ensemble of ‘empty’ layers. A detailed comparative analysis of the results obtained by exact direct simulation (MCM) and approximate algorithms (CR, FCR) for the problems of gamma radiation transfer through a ‘thick’ water layer containing a Poisson ensemble of ‘empty’ layers or balls is presented.
Error identities for the reaction–convection–diffusion problem and applications to a posteriori error control
Authors: Repin Sergey I. 
Published: August 2022

AbstractThe paper is devoted to a posteriori error identities for the stationary reaction–convection–diffusion problem with mixed Dirichlét–Neumann boundary conditions. They reflect the most general relations between deviations of approximations from the exact solutions and those values that can be observed in a numerical experiment. The identities contain no mesh dependent constants and are valid for any function in the admissible (energy) class. Therefore, the identities and the estimates that follow from them generate universal and fully reliable tools of a posteriori error control.
Steigerung der Belastbarkeit von Tragstrukturen durch effektives Vorspannen
Authors: Güngör Burcu , Husmann Henning , Groche Peter 
Published: August 2022

Abstract
Hybridstrukturen aus Metallen und Faser-Kunststoff-Verbunden (FKV) bieten vielseitige Vorteile, da in ihnen die Eigenschaften zweier grundlegend verschiedener Werkstoffarten vereint sind. Durch ein gezieltes Ausnutzen des unterschiedlichen Materialverhaltens während der Umformung werden Metallblechstrukturen und FKV-Schlaufen nicht nur miteinander gefügt, sondern auch in einen vorgespannten Zustand gebracht. Dieser führt zu deutlichen Festigkeits- und Steifigkeitssteigerungen bei geringem Mehrgewicht. Anhand eines anwendungsnahen Profils wird das Potenzial dieser Technologie validiert.
Die Fabrik der Zukunft
Authors: Burggräf Peter , Adlon Tobias , Schneidermann Dennis , Uelpenich Jérôme , Xu Tingni , Schupp Steffen , Dackweiler Jonas , Geukes Corinna 
Published: August 2022

Abstract
Aufgrund zahlreicher Herausforderungen für produzierende Unternehmen durch sich ständig ändernde Anforderungen und neue technologische Entwicklungen fehlt ein visionäres Bild für die Fabrik der Zukunft. Die Unkenntnis über zukünftig relevante Produktionstrends und Technologien erschwert die erfolgreiche Entwicklung eines zukunftsorientierten Produktionssystems. Um die Planung zukünftiger Produktionssysteme und Fabriken zu verbessern, haben die Autoren eine Befragung durchgeführt, an der 194 führende Unternehmen aus verschiedenen Branchen teilgenommen haben. Anhand von fünf Schlüsseldimensionen konnten relevante Zukunftstrends für die Fabrik der Zukunft identifiziert werden.
Flexibilität, Wandlungsfähigkeit und Agilität in der Fabrikplanung
Authors: Erlach Klaus , Berchtold Marc-André , Gessert Stephan , Kaucher Christian , Ungern-Sternberg Roman 
Published: August 2022

Abstract
Die Methodenentwicklung zum Umgang mit Veränderungen ist eines der wesentlichen Forschungsfelder der Fabrikplanung. Fehlende Klarheit im Begriffskanon der Veränderungsfähigkeit erschwert die Entwicklung von stringenten Gestaltungsansätzen für Fabriksysteme. Um dies zu verbessern, teilt der Beitrag Veränderungen hinsichtlich des Nachfrageverlaufs in drei Kategorien ein. Jeder Kategorie ist eine Klasse der Veränderungsfähigkeit mit der resultierenden Fabrikeigenschaft zugeordnet. Für die Fabrikplanung ergeben sich daraus je Klasse vier ‚Befähiger‘, die sich zudem in einem Lösungsprinzip zusammenfassen lassen.
Rickets in a child with prolonged acquired hypothyroidism secondary to Hashimoto’s thyroiditis
Authors: Schulmeister Caroline , Lee Jason , Perwad Farzana , Long Roger , Srinivasan Shylaja 
Published: August 2022

Summary
Skeletal abnormalities with delayed bone age and decreased linear bone growth are commonly found in children with prolonged juvenile hypothyroidism. However, rachitic bone abnormalities have not been previously reported in children with acquired hypothyroidism. Here, we present a case of newly found rickets in an 8-year-old female with untreated acquired hypothyroidism secondary to Hashimoto’s thyroiditis. Laboratory finding for abnormalities in calcium/phosphorus homeostasis and hormones that regulate skeletal health was normal. Her radiographic anomalies resolved with levothyroxine treatment alone, suggesting that hypothyroidism was the etiology of the rickets. To our knowledge, this is the first case report of rickets associated with long-standing severe acquired hypothyroidism that resolved exclusively with thyroid repletion.

Learning points

Thyroid hormone plays an important role in bone mineralization.

Prolonged hypothyroidism can result in rachitic bone abnormalities noted on radiographs.

Hypothyroidism should be considered in the evaluation of a child with rickets.
Biología floral de accesiones de Arracacia xanthorrhiza Bancr. del banco de germoplasma de Colombia
Authors: Orozco-Orozco Luz Fanny , López-Hoyos Jaime Horacio , Espitia-Negrete Laura Beatriz , Velásquez-Arroyo Carlos Enrique , Rodríguez-Rodríguez Oscar Jair , Garnica-Montaña Johanna Paola 
Published: August 2022

Introducción. La arracacha es una raíz tuberosa originaria de los Andes con mayores producciones en Brasil y Colombia. Entre los limitantes del cultivo se destaca la poca información sobre su biología reproductiva (floración y producción se semilla sexual), que dificulta la obtención de nuevas variedades. El Sistema de Bancos de Germoplasma de la Nación para la Alimentación y la Agricultura (SBGNAA) de Colombia, en custodia de la Corporación Colombiana de Investigación Agropecuaria (AGROSAVIA) conserva 71 accesiones de Arracacia xanthorrhiza Bancr., donde la floración es frecuente, hasta en el 10 % de estas. Objetivo. Caracterizar la estructura floral y describir el ciclo reproductivo de nueve accesiones de arracacha florecidas entre los años 2019 y 2020. Materiales y métodos. El estudio se realizó en el Centro de Investigación La Selva, Rionegro, Antioquia, Colombia, donde se conserva el banco de germoplasma. Se realizó la caracterización morfológica de las accesiones mediante el registro de dieciséis variables a nivel de estructura floral, además, del seguimiento al ciclo reproductivo. Resultados. Se obtuvieron cuatro agrupamientos donde las variables color de polen, color de anteras, color de pétalos, altura de planta, número de flores estaminadas y número de semillas, tuvieron el mayor aporte a la variabilidad encontrada. El ciclo reproductivo floral duró 73 días en promedio, en el cual se encontraron cuatro fenofases: 1. aparición de la umbela, 2. separación del estilo, 3. liberación de polen y 4. llenado de frutos, con una duración promedio de 11, 3, 4 y 55 días, respectivamente. Entre los factores que indujeron la floración en arracacha se encontraron: edad, genética de la planta y clima. Conclusión. Se caracterizaron las estructuras florales y el ciclo reproductivo de las nueve accesiones de arracacha florecidas entre los años 2019 y 2020.
Viscoelastic properties of bioinspired asymmetric helicoidal CFRP composites
Authors: Nwambu Chidume Nnamdi , Robert Colin , Alam Parvez 
Published: August 2022

AbstractA dynamic mechanical thermal analyser (DMTA) was used to develop insight into the dynamic mechanical properties of bioinspired asymmetric helicoidal carbon fibre reinforced plastic (CFRP) composites as a function of fibre architecture using inter-ply stacking angles of 0° (UD), 0/90° (cross-ply), 5°, 15°, 10°, 20°, 25° and 30°. Here, we show that the dynamic mechanical properties of asymmetric helicoidal CFRP composites are linearly correlated to their oriented ply fractions between 0° and 45° off the loading axis. We furthermore provide evidence from the tan-δcurves that asymmetric helicoidal CFRP composites are heterogeneous materials with separate viscoelastic phases and glass transition temperatures, resulting from the stacking architectures of these composites. Inter-ply stacking angles are finally noted as critical factors affecting the extent of macromolecular mobility within helicoidally stacked continuous fibre CFRP composites.Graphical abstract
A sessão de psicanálise como gênero do discurso: enquadre, terapia e encontro de vozes em visada bakhtiniana
Authors: Moll Eduardo da Silva , Di Fanti Maria da Glória Corrêa , Rosa Kelli Machado da 
Published: August 2022

Embora pouco debatido na área dos estudos bakhtinianos, um marco da produção teórica do Círculo de Bakhtin foi a crítica de Volóchinov ao freudismo. Refletindo criticamente sobre o posicionamento do autor acerca da psicanálise, este artigo objetiva investigar o pequeno acontecimento social psicanalítico como um gênero do discurso em sua especificidade terapêutica, considerando o entrecruzamento de vozes constitutivo desse evento. Com uma pesquisa bibliográfica, recuperamos os pressupostos de Bakhtin e o Círculo que embasam o construto de gênero do discurso e investigamos o papel do enquadre na terapia psicanalítica freudiana. Conceitos como o de arquitetônica e de heterodiscurso para o Círculo, assim como o de resistência e de transferência para Freud ajudaram a explorar o lugar do setting na terapia. Defendemos que a relação discursiva psicanalítica especifica-se pela possibilidade de fazer da interação discursiva um espaço-tempo aberto ao diálogo inconclusível próprio do encontro terapêutico e da palavra em elaboração.
Inflammation in Children with CKD Linked to Gut Dysbiosis and Metabolite Imbalance
Authors: Holle Johannes , Bartolomaeus Hendrik , Löber Ulrike , Behrens Felix , Bartolomaeus Theda U.P. , Anandakumar Harithaa , Wimmer Moritz I. , Vu Dai Long , Kuhring Mathias , Brüning Ulrike , Maifeld Andras , Geisberger Sabrina , Kempa Stefan , Schumacher Fabian , Kleuser Burkhard , Bufler Philip , Querfeld Uwe , Kitschke Stefanie , Engler Denise , Kuhrt Leonard D. , Drechsel Oliver , Eckardt Kai-Uwe , Forslund Sofia K. , Thürmer Andrea , McParland Victoria , Kirwan Jennifer A. , Wilck Nicola , Müller Dominik 
Published: August 2022

Significance Statement
Controlling chronic inflammatory processes, which are a major risk factor for cardiovascular disease, is of outstanding importance in CKD to reduce the rate of CKD-associated morbidity. This investigation connects microbial dysbiosis and bacterial metabolite imbalance to a proinflammatory immune cell signature. The fact that these dysbiosis-driven immunologic changes are already detectable in children with CKD, in whom comorbidities usually found in adults are absent, highlights the importance and specificity of CKD-related microbiota-immune interaction for chronic inflammation. Personalized dietary interventions and microbiota-targeted therapies may be a promising area of research to improve the prognosis of young and old patients with CKD.

Background
CKD is characterized by a sustained proinflammatory response of the immune system, promoting hypertension and cardiovascular disease. The underlying mechanisms are incompletely understood but may be linked to gut dysbiosis. Dysbiosis has been described in adults with CKD; however, comorbidities limit CKD-specific conclusions.

Methods
We analyzed the fecal microbiome, metabolites, and immune phenotypes in 48 children (with normal kidney function, CKD stage G3–G4, G5 treated by hemodialysis [HD], or kidney transplantation) with a mean±SD age of 10.6±3.8 years.

Results
Serum TNF-α and sCD14 were stage-dependently elevated, indicating inflammation, gut barrier dysfunction, and endotoxemia. We observed compositional and functional alterations of the microbiome, including diminished production of short-chain fatty acids. Plasma metabolite analysis revealed a stage-dependent increase of tryptophan metabolites of bacterial origin. Serum from patients on HD activated the aryl hydrocarbon receptor and stimulated TNF-α production in monocytes, corresponding to a proinflammatory shift from classic to nonclassic and intermediate monocytes. Unsupervised analysis of T cells revealed a loss of mucosa-associated invariant T (MAIT) cells and regulatory T cell subtypes in patients on HD.

Conclusions
Gut barrier dysfunction and microbial metabolite imbalance apparently mediate the proinflammatory immune phenotype, thereby driving the susceptibility to cardiovascular disease. The data highlight the importance of the microbiota-immune axis in CKD, irrespective of confounding comorbidities.
70 ANIVERSARIO DE LA ACADEMIA MEXICANA DE PEDIATRÍA A.C. “RESURGIMIENTO DE LA INSTITUCIÓN”
Authors: Loredo Abdalá Arturo 
Published: August 2022

La Academia Mexicana de Pediatría A.C. “Órgano Consultor del Gobierno Federal” cumplió 70 años de vida. Fue el 6 de junio de 1951 y gracias a la iniciativa del Dr. Roberto L. Sánchez, presidente de la Asociación Nacional de Pediatría de México, que se declara legalmente constituida la Academia Mexicana de Pediatría y nombra en la primera mesa directiva como presidente al Dr. Mario A. Torroella. La AMP tiene como objetivo ser el órgano colegiado más alto de México en esta disciplina, convirtiéndose en el cuerpo consultivo y consejero de los organismos oficiales y privados en todo lo relacionado con la salud de los niños.
Developing the Love of Learning Scale for Adult Students
Authors: Aljaji Raja Mohamed Deeb , Al-Hidabi Dawood A. , Al-Hammadi Abdullah Othman 
Published: August 2022

The study aimed at developing the love of learning scale for adults. The scale consisted of 15 situations to measure three dimensions namely intimacy, passion, and commitment towards learning. The scale was standardized on a sample of 111 university male and female students from the 4th level of the Faculty of Education, Sana’a University, Yemen. The validity and reliability of the scale was (0.81) based on Cronbach’ Alpha. The results of the study showed that the level of the love of learning was of average level.
Keywords: love of learning, scale development, adult students