bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Novel Electrochemical Sensor Based on Poly(1,5‐diaminonaphthalene) and Poly(1,2‐diaminoanthraquinone) Core‐shell Composite Electrodes for Effective Voltammetric Determination of Nitrite
Authors: Maher Reham , Khalifa Ziad , Hathoot Abla Ahmed , Azzem Magdi Abdel 
Published: August 2022

AbstractIn this article, poly(1,2‐diaminoanthraquinone) (pDAAQ) and poly(1,5‐diaminonaphthalene) (pDAN) were electrochemically deposited layer by layer on a glassy carbon electrode (GCE) to generate pDAAQ/pDAN@GCE and pDAN/pDAAQ@GCE composite electrodes, respectively. The morphology and characteristics of the modified electrodes were investigated via electrochemical impedance spectroscopy)EIS), Fourier transform infrared spectroscopy (FT‐IR), and scanning electron microscopy)SEM). The obtained results reveal the outstanding performance of the pDAN/pDAAQ@GCE electrode for electrochemical nitrite sensing where pDAAQ plays a vital role as the inner layer. Cyclic voltammetry (CV), linear sweep voltammetry (LSV), and differential pulse voltammetry (DPV) measurements revealed that the oxidation peak current of nitrite was proportional to its concentration. The best LSV results were obtained in a concentration range of 10–150 μM, with a limit of detection of 1.2 μM. Furthermore, the pDAN/pDAAQ@GCE composite electrode was used to determine nitrite ions in real water samples with good results.
CircRNA RNF10 inhibits tumorigenicity by targeting miR‐942‐5p/GOLIM4 axis in breast cancer
Authors: Kan Binghua , Yan Guiru , Shao Yuan , Zhang Ziliang , Xue Hui 
Published: August 2022

AbstractWe aimed to explore the action of a circRNA produced by ring finger protein 10 (circ_RNF10; hsa_circ_0028899) in the malignant behaviors of breast cancer (BC) and to explore its potential action‐of‐mechanism. The levels of circ_RNF10, miR‐942‐5p and Golgi integral membrane protein 4 (GOLIM4) were measured through quantitative real‐time polymerase chain reaction, western blot, or immunohistochemistry, and the competing endogenous RNA (ceRNA) relationship among them was verified by dual‐luciferase reporter assay. Cell counting kit‐8, 5‐ethynyl‐2′‐deoxyuridine, and colony formation assays, transwell assays, and flow cytometry were used to examine cell proliferation, migration and invasion, and apoptosis, respectively. Levels of proliferation and invasion‐related markers were determined by western blot. Xenograft assay was performed to assess tumor growth. Circ_RNF10 level was significantly reduced in BC tissues and cells. Elevation of circ_RNF10 blocked BC cell proliferation, migration and invasion while promoted the apoptosis in vitro, companied with decreased PCNA and Twist1 and increased E‐cadherin. Furthermore, upregulating circ_RNF10 delayed tumor growth of BC cells in nude mice. Mechanistically, circ_RNF10 acted as a ceRNA for miR‐942‐5p, and miR‐942‐5p could target GOLIM4. In addition, miR‐942‐5p overexpression reversed the influence of circ_RNF10 overexpression on BC progression. Furthermore, GOLIM4 silencing attenuated the inhibitory effect of miR‐942‐5p knockdown on BC progression. We found that circ_RNF10 suppressed BC malignant behavior by targeting miR‐942‐5p/GOLIM4 axis.
Effects of mulching with Solanum spp. straw on phosphorus, iron, and cadmium uptake by rice plants
Authors: Shi Jun , Lu Jing , Li Xiufen , Xiang Zufen , Liu Dingyou , Liao Shuang , Yu Huaqing , Zheng Tengda , Huang Tingyou 
Published: August 2022

AbstractThe cadmium (Cd) contaminated paddy soil has seriously affected the safe production of rice, and returning straw to fields changes the Cd accumulation in crops. To decrease the Cd accumulation in rice and clarify the relationships among phosphorus (P), iron, and Cd contents in rice, the effects of Solanum spp. (including non‐hyperaccumulators Solanum diphyllum and Solanum alatum, and Cd‐hyperaccumulators Solanum nigrum and Solanum photeinocarpum) straws on the P, iron, and Cd uptakes in rice in Cd‐contaminated soil were investigated. The application of four Solanum spp. straws increased the biomass of rice. Only the S. alatum straw increased the chlorophyll a, chlorophyll b, total chlorophyll, and carotenoid contents in rice. Regarding the P, iron, and Cd contents in rice, the four Solanum spp. straws either decreased the P content or had no significant effects, and tended to increase and decrease the iron and Cd contents, respectively. In addition, the Cd content was negatively correlated with the iron content and the soil available P concentration, and was positively correlated with the soil exchangeable Cd concentration. Therefore, Solanum spp. straws can decrease the Cd uptake and increase the iron uptake by rice. Furthermore, the Cd content in rice is related to the iron content in rice as well as the concentrations of soil available P and soil exchangeable Cd.
Effect of manifold injection of 1‐hexanol on a reactivity controlled compression ignition engine fuelled with neem oil methyl ester blend
Authors: Vajravel Vinodkumar , Alagu Karthikeyan 
Published: August 2022

AbstractThe novelty of this research aims to attain low‐temperature combustion with the help of reactivity controlled compression ignition (RCCI) in a single cylinder, four‐stroke diesel engine by premixing the low reactivity fuel (LRF) such as 1‐hexanol with air in the intake manifold along with high reactivity fuel (HRF) such as neem oil methyl ester in the volumetric ratio of 80:20 (B20) as a primary fuel. HRF has been utilized as a primary fuel through the main injector along with the manifold injection of LRF fuel through a secondary injector at various energy shares, such as 10%, 20%, 30%, and 40%, and the fuel combinations were designated as B20HI10, B20HI20, B20HI30, and B20HI40. The readings were noted from no load to full load and the experiment showed that the brake thermal efficiency (BTE) was increased in RCCI mode up to 30% 1‐hexanol share compared with B20 due to its better combustion, which was evident by higher heat release rate (HRR); beyond 30%, there was a drop in BTE due to the reduction in pilot fuel quantity. Oxides of nitrogen and smoke were significantly reduced for all combinations in RCCI mode, whereas hydrocarbon and carbon monoxide emissions were increased substantially. A substantial increase in peak pressure and HRR was noticed in RCCI mode compared with conventional mode due to its better homogeneity and prolonged ignition delay. From the findings, this research suggests that B20‐1‐hexanol combinations in RCCI mode can be an attractive replacement for diesel fuel.
Early administration of lenalidomide after allogeneic hematopoietic stem cell transplantation suppresses graft‐versus‐host disease by inhibiting T‐cell migration to the gastrointestinal tract
Authors: Tsubokura Yukie , Yoshimura Hideaki , Satake Atsushi , Nasa Yutaro , Tsuji Ryohei , Ito Tomoki , Nomura Shosaku 
Published: August 2022

AbstractIntroductionAllogeneic hematopoietic stem cell transplantation (aHSCT) is a curative treatment for hematopoietic malignancies. Graft‐versus‐host disease (GVHD) is a major complication of aHSCT. After transplantation, the balance of immune conditions, such as proinflammatory cytokine level and T‐cell subset count, influences GVHD magnitude. Lenalidomide (LEN) is an immunomodulatory drug used for treating several hematological malignancies such as multiple myeloma, adult T‐cell lymphoma/leukemia, and follicular lymphoma. However, the impact of LEN on immune responses after aHSCT has not been elucidated.MethodsWe analyzed the lymphocyte composition in naïve mice treated with LEN. Subsequently, we treated host mice with LEN, soon after aHSCT, and analyzed GVHD severity as well as the composition and characteristics of lymphocytes associated with GVHD.ResultsUsing a mouse model, we demonstrated the beneficial effects of LEN for treating acute GVHD. Although natural killer cells were slightly increased by LEN, it did not significantly change T‐cell proliferation and the balance of the T‐cell subset in naïve mice. LEN did not modulate the suppressive function of regulatory T cells (Tregs). Unexpectedly, LEN prevented severe GVHD in a mouse acute GVHD model. Donor‐derived lymphocytes were more numerous in host mice treated with LEN than in host mice treated with vehicle. Lymphocyte infiltration of the gastrointestinal tract in host mice treated with LEN was less severe compared to that in host mice treated with vehicle. The percentage of LPAM‐1 (α4β7‐integrin)‐expressing Foxp3−CD4+ T cells was significantly lower in host mice treated with LEN than in host mice treated with vehicle, whereas that of LPAM‐1‐expressing Tregs was comparable.ConclusionsLEN may be useful as a prophylactic agent for acute GVHD‐induced mortality through the inhibition of lymphocyte migration to the gastrointestinal tract. Our data show the effect of LEN on immune responses early after aHSCT and suggest that cereblon, a molecular target of LEN, may be a therapeutic target for preventing acute GVHD‐induced mortality.
Brain and spinal cord metastases with seminoma: A case report
Authors: Yumioka Tetsuya , Morizane Shuichi , Makishima Karen , Adachi Tadashi , Moriyasu Emika , Iwamoto Hideto , Hikita Katsuya , Honda Masashi , Umekita Yoshihisa , Takenaka Atsushi 
Published: August 2022

IntroductionBrain and spinal cord metastases from testicular cancer occur rarely, and metastases with seminoma are extremely rare.Case presentationA 42‐year‐old man who was diagnosed with seminoma and multiple metastases underwent first‐line and salvage chemotherapy. Brain metastases were noted; consequently, surgery, third‐line chemotherapy, and whole‐brain irradiation were performed. Subsequently, paralysis developed, and spinal cord metastases were detected. He received fourth‐line chemotherapy but died. Pathological autopsy revealed metastases only in the spinal cord. The cause of death was considered respiratory failure due to cervical spinal cord involvement from spinal metastases.ConclusionBrain and spinal cord metastases from seminoma are rare. Thus, similar future cases should be treated appropriately.
Distinctive nail pattern following androgen replacement therapy
Authors: Miyata Ippei , Nagai Atsushi 
Published: August 2022

IntroductionA distinctive nail pattern in a patient undergoing androgen replacement therapy is presented hereby.Case presentationA 47‐year‐old male patient noticed a peculiar “washboard‐like” pattern on his fingernails. He had been undergoing androgen replacement therapy for late onset hypogonadism syndrome. The patient realized his nails were growing faster after his therapy was altered from a tri‐weekly basis to a bi‐weekly basis.ConclusionThis phenomenon is likely to be attributed to the androgen replacement therapy, as the spacing between the ridges were widening in concordance with the strengthening of the therapy.
“My literacies expand over two languages”: Language and literacy autobiographies as justice‐oriented teacher education
Authors: Neville Mary , Johnson Susana Ibarra 
Published: August 2022

AbstractIn this study, the researchers explore how teacher candidates (TCs) across one content area literacies course and one bilingual education course engaged with their past linguistic experiences through two literacy autobiography assignments across the two separate classes. Borrowing from culturally sustaining, multiliteracies, and translanguaging pedagogies, the researchers examined students' associations with their past language and literacy experiences. Findings demonstrate that the assignment allowed participants to examine past linguistic experiences which informed their considerations of themselves and their future students as enactors of language and literacy. The researchers examine how a culturally sustaining, translingual, and multiliteracies approach may help TCs view their own and their future students' literacy repertories as texts.
In vitro assessment of varying peptide surface density on the suppression of angiogenesis by micelles displaying αvβ3 blocking peptides
Authors: Bhushan Neha Phani , Stack Trevor , Scott Evan A. , Shull Kenneth R. , Mathew Benjamin , Bijukumar Divya 
Published: August 2022

AbstractLigand targeted therapy (LTT) is a precision medicine strategy that can selectively target diseased cells while minimizing off‐target effects on healthy cells. Integrin‐targeted LTT has been developed recently for angiogenesis‐related diseases. However, the clinical success is based on the optimal design of the nanoparticles for inducing receptor clustering within the cell membrane. The current study focused on determining the surface density of Ser‐Asp‐Val containing anti‐integrin heptapeptide on poly (ethylene glycol)‐b‐poly(propylene sulfide) micelles (MC) required for anti‐angiogenic effects on HUVECs. Varying peptide density on PEG‐b‐PPS/Pep‐PA MCs (Pep‐PA‐Peptide‐palmitoleic acid) was used in comparison to a random peptide (SGV) and cRGD (cyclic‐Arginine‐Glycine‐Aspartic acid) construct at 5%‐density on MCs. Immunocytochemistry using CD51/CD31 antibody was performed to study the integrin blocking by MCs. In addition, the expression of VWF and PECAM‐1, cell migration and tube formation was evaluated in the presence of PEG‐b‐PPS/Pep‐PA MCs. The results show PEG‐b‐PPS/SDV‐PA MCs with 5%‐peptide density to achieve significantly higher αvβ3 blocking compared to random peptide as well as cRGD. In addition, αvβ3 blocking via MCs further reduced the expression of vWF and PECAM‐1 angiogenesis protein expression in HUVECs. Although a significant level of integrin blocking was observed for 1%‐peptide density on MCs, the cell migration and tube formation were not significantly affected. In conclusion, the results of this study demonstrate that the peptide surface density on PEG‐b‐PPS/Pep‐PA MCs has a significant impact in integrin blocking as well as inhibiting angiogenesis during LTT. The outcomes of this study provides insight into the design of ligand targeted nanocarriers for various disease conditions.
How to make the most of routine outcome monitoring (ROM): A multitude of clinical decisions and nuances to consider
Authors: Aafjes‐van Doorn Katie , de Jong Kim 
Published: August 2022

AbstractRoutine outcome monitoring (ROM) involves the use of patient‐reported standardized outcome measures to monitor progress throughout the course of treatment, followed by feedback of the patient's scores to the therapist. The potential benefits of ROM have been established, however, from our own experiences, we know that the implementation in clinical practice can be challenging. We therefore wanted to explore in more detail exactly how we might be able to apply ROM in difficult clinical contexts. The inspiring case illustrations in this issue of Journal of Clinical Psychology: In Session highlight the heterogeneity in ROM systems, and the way in which ROM can be used in treatment. Just as there are many ways of interpreting a survey data‐point, there are also many ways in which ROM may be used to complement the treatment and supervision. Whether or not ROM is implemented may partly be determined by clinic policies and routines, but there remain a multitude of clinical decisions that require careful consideration by the individual therapist. To complement the evidence supporting the benefits of using ROM, further empirical support and clinical guidance is needed on how exactly therapists are to use ROM in their work and how ROM may be used in evidence‐based practice. We make suggestions for additional uses of ROM for deliberate practice, and teletherapy practice, and look toward novel ways of assessing progress in the near future.
Point‐of‐care ultrasound to confirm the position of bronchial blockers in children
Authors: Wang Junxia , Huang Xin , Hu Weidong , Cheng Xianling , Zhang Bin 
Published: August 2022

AbstractPurposeWe described the accuracy of ultrasound in determining the position of bronchial blockers (BBs) in children underwent thoracoscopic surgery.MethodsWe enrolled 52 children with ASA grade I‐III who received thoracoscopic surgery with placement of BBs. Point‐of‐care ultrasound was performed according to the BLUE protocol. The ultrasound‐guided lung sliding sign and curtain sign were used to assess the position of BBs. The accuracy of ultrasound in evaluating the position of BBs, as well as the accuracy and operating time of sliding sign and curtain sign at each examination point were recorded and compared.ResultsThe accuracy of ultrasound in evaluating the position of BBs was 88% (46/52, 95% CI 0.69–0.97). When using the curtain sign to assess the position of BBs, the accuracy was 90% (94/104, 95% CI 0.78–0.96), which was significantly higher than when using the sliding sign (65% (136/208), 95% CI 0.55–0.74) (p = 0.002). The accuracy of curtain sign at the left mid‐axillary line‐diaphragm and the right mid‐axillary line‐diaphragm was respectively 96% (50/52, 95% CI 0.80–0.99) and 84% (44/52, 95% CI 0.65–0.95), which were higher than that of sliding sign at upper blue points and lower blue points. There was no significant difference in the operating time between two ultrasound signs (the curtain sign, 13.4 ± 8.2 s vs. the lung sliding sign, 16.2 ± 10.0 s, p = 0.065).ConclusionPoint‐of‐care ultrasound can effectively assess the position of BBs. The accuracy of using the curtain sign at the mid‐axillary line‐diaphragm is higher than that of using the lung sliding sign at the anterior chest wall.
A review of the mineralogical and chemical composition of nanoparticles associated with coal fires
Authors: Silva Luis F. O. , Schindler Michael , Alavijeh Mozhgan Akbari , Finkelman Robert B. , Oliveira Marcos L. S. 
Published: August 2022

AbstractThis review summarizes our current knowledge on the health and environmental impact as well as the mineralogical and geochemical composition of nanoparticles (NPs) associated with coal fires. It will furthermore recommend new sampling and characterization protocols to gain a better understanding of the various types of NPs that are formed either through high‐temperature nucleation and alteration processes or via low‐temperature dissolution‐reprecipitation and weathering processes. Coal fires affect the immediate environment of coal‐producing areas and produce positive and negative feedback to climate change through the emission of carbon‐ and sulfate‐bearing gases and aerosols, respectively. Nanoparticles form during and after coal fires. They are composed of mainly soot and tar particles as well as amorphous phases, minerals, and complex mixtures of amorphous phases and minerals. It is recommended that NPs for mineralogical studies should be collected using impactors (a new generation of collectors for particulate matter, such as the TPS100 NP sampler) or that borosilicate filters at the openings of pipes and chambers be used to collect and measure gases emitted by coal fires. Furthermore, assemblages of NPs occurring at the mouths of coal fire vents should be examined using a combination of focused ion beam (FIB) technology and transmission electron microscopy (TEM), and those containing ion‐ or electron‐beam sensitive phases should be examined with the corresponding cryo‐techniques, such as cryo‐FIB, cryo‐ion mill, and cryo‐TEM. The mineralogical and chemical composition of NP‐bearing bulk samples should be examined with spectroscopy techniques such as X‐ray photoelectron spectroscopy, 13C nuclear magnetic resonance spectroscopy, or time‐of‐flight secondary ion mass spectroscopy.
Transfusion burden in early childhood plays an important role in iron overload in Diamond‐Blackfan anaemia
Authors: de Wilde Jonathan R. A. , van Dooijeweert Birgit , van Vuren Annelies J. , Huisman Elise J. , Smiers Frans J. , van der Veer Arian , van Wijk Richard , van Solinge Wouter W. , Nieuwenhuis Edward E. S. , van Beers Eduard J. , Bartels Marije 
Published: August 2022

AbstractIn Diamond‐Blackfan anaemia (DBA), iron overload (IO) is common in transfusion‐dependent patients, yet has also been reported in non‐transfusion‐dependent patients. We explored the incidence of IO in transfusion‐dependent and non‐transfusion‐dependent DBA patients. We observed hepatic IO in 65% of patients analysed with MRI, including three patients that were only treated with transfusions in the past. Whereas overall ferritin levels and liver iron content correlated, ferritin levels did not reflect total body iron adequately. Our data suggest that transfusion burden in the past plays an important role in IO in DBA, and should be taken into account during follow up.
Integrated Drought Index based on Vine Copula Modelling
Authors: Kanthavel P. , Saxena C. K. , Singh R. K. 
Published: August 2022

AbstractAs a natural hazard, drought is a complex multivariate phenomenon that does not depend on only one hydrometeorological variable, as well as, considering a particular kind of drought may not be effective for drought management. Considering this, many multivariate drought indices have been developed based on linearity assumptions or conventional copulas assuming symmetric relationships among univariate drought indices. In this study, D‐vine copula was applied to construct a four‐dimensional index, named as Integrated Drought Index (IDI), by combining four univariate drought indices (Standardized Precipitation Index [SPI], Reconnaissance Drought Index [RDI], Standardized Soil moisture Index [SSI] and Standardized stream flow Drought Index [SDI]) to better reflect many hydrometeorological variables (precipitation, evapotranspiration, soil moisture and stream flow) and different kinds of drought (meteorological, agricultural and hydrological) simultaneously. Vine copula was used to solve nonlinear and asymmetric relationships among drought indices due to its flexibility over the free selection of copula(s) in each step of hierarchical structure in high dimensional modelling. The IDI was constructed for 1‐ and 4‐month timescales for the upper Tapti basin of the central region in India. The performance of IDI was tested with dependence measures (Pearson's correlation coefficient, Mutual Information) and evaluated against the Terrestrial Water Storage Anomaly data derived from the Gravity Recovery and Climate Experiment (GRACE) mission. Spatial analysis of drought was carried out by fuzzy c‐means (FCM) clustering algorithm with IDI. IDI based on vine copula solved the nonlinear and asymmetric relationships among different variables associated with the occurrence of droughts effectively with a reduction of uncertainty as compared to the single drought indices for different kinds of droughts. Analysis revealed spatially different drought risks in the upper and lower river basins. In general, the vine copula addresses nonlinear and asymmetric relationships that exist between the variables associated with natural hazards like drought.