bluuebunny/crossref_metadata_2025_split huggingface dataset:
Short-term prognostic value of clinical data in hospitalized patients with intermediate-risk acute pulmonary embolism
Authors: Liu Jichun , Liu Yuanyuan , Zhang Feilong , Cong F , Ling Yang , Fang Ping , Xie Xiangrong , Wang Xianghai , Yang Hao , Wei Youquan , Wang Jinfeng 
Published: March 2022

Abstract
Background: Intermediate-risk APE patients usually defined as hemodynamically stable, comprehending a great therapeutic dilemma , since some can deteriorate and eventually require reperfusion therapy .To evaluate the predictive values of short-term prognosis for intermediate-risk acute pulmonary embolism (APE) patients based on clinical data. Methods: A retrospective cohort of 74 intermediate-risk APE patients confirmed by computed tomography pulmonary angiography (CTPA) was analyzed in the present study. Adverse clinical events outcomes included PE-related in-hospital deaths, critical systolic blood pressure consistently under 90 mmHg, refractory to volume loading and vasopressor infusion requirements, mechanical ventilation, and cardiopulmonary resuscitation. APE patients were stratified into two groups based on their adverse outcomes (n = 25) and controls (n = 49). Then, the clinical data of the two groups were compared. The receiver operating characteristic (ROC) curve was employed to explore the predictive value of white blood cell (WBC) counts and the ratio of right to left ventricular short-axis (RV/LV). Results: Brain natriuretic peptide, WBC count, and the RV/LV were higher in patients with adverse outcomes compared to controls. The APE patients with adverse outcomes presented significantly higher rates of syncope, Negative T waves (TWI) in V1-V3, intermediate-high risk, thrombolytic therapy, and low arterial oxygen saturation (SaO2) compared to controls. In the multivariate logistic regression analysis, the SaO2＜90%, [odds ratio (OR) 5.343, 95% confidence interval (CI) 1.241-23.008; p = 0.024], RV/LV ratio (OR 7.429, 95% CI 1.145-48.209; p = 0.036), Syncope (OR 12.309, 95% CI 1.702-89.032; p = 0.013) ,TWI in V1-V3 (OR 5.617, 95% CI 1.228-25.683; p = 0.026), and WBC count (OR 1.212, 95% CI 1.035-1.419; p = 0.017) were independent predictors of in-hospital adverse outcomes among APE patients. The ROC curves indicated that the RV/LV ratio can be used to predict adverse outcomes (AUC = 0.748, p＜0.01). Moreover, an RV/LV > 1.165 was predictive for adverse outcomes with sensitivity and specificity of 88.00 and 59.20%, respectively. The WBC counts were also able to predict adverse outcomes (AUC = 0.752, p＜0.01). A WBC count > 9.05 was predictive for adverse outcomes with sensitivity and specificity of 68.00 and 73.50%, respectively.Conclusion: Overall, a SaO2＜90%, RV/LV ratio, Syncope, TWI in V1-V3, and WBC counts could independently predict adverse outcomes in intermediate-risk APE patients.
Analysing the Component Changes and Microbial Community Structures in Huangjiu undergoing Rancidification
Authors: 胡 健 , Liu Shuangping , Liu Caixia , Huang Yuanyuan , Mao Jian 
Published: March 2022

Abstract
In an effort to develop rapid tests to grade the quality of rancidification characteristics during the traditional pottery jar storage process of Huangjiu, the microbial community structures and associated compositional variation at different stages of the rancidification were analyzed. A comparative analysis of component variations between rancidification and normal Huangjiu samples was carried out by HPLC. Microbial pollution induced rancidification by affecting alcohol strength, acidity, amino acid nitrogen, and conductivity indexes. Moreover, microelements, such as organic acids, amino acids, and bioamine also changed significantly. According to the PacBio RS II analysis of J-10 and J-13, J-10 contained 10 bacteria genera, 3 fungi genera, and 1 unclassified binuclear subkingdom fungus, at a significantly higher relative abundance compared to that of J-13 (p-value<0.01). The relative abundance of only 1 bacterium genus and 1 fungus genus in J-10 was significantly lower compared to those in J-13 (p-value<0.01). This indicated that microbial community structures vary in Huangjiu depending on the rancidification time. Increasing rancidification time caused the relative abundance of microbial community structure to also increase. Collectively, this study can serve as a reference point for researchers and industry partners interested in discussing the influence of rancidification on the quality, health safety, and industrialized development of Huangjiu.
Parasocial Relationships and Repeated Viewing of YouTube and TV Channels: A Mediated Moderated Framework
Authors: Hasan Asif , Rahman Eisha , Khan Amna , Abbas Mariyam 
Published: March 2022

Abstract
With the increasing penetration of the internet and modern entertainment-related technologies, there is a shift and surge in media usage behavior. Owing to the gravity of this issue, the researchers probed the predictors of audiences' repeated usage of certain media, i.e., TV and YouTube channels. Moreover, they explored the mediating influence of parasocial relationships on the relationship between media addiction and repeated usage. They also studied the moderation of emotional engagement on the relationship between media addiction and parasocial relationships. The nature of this study is cross-sectional and descriptive. A total of 400 participants were approached via convenience sampling and were requested to fill the questionnaires. However, the researchers received only 325 complete responses. Therefore, the data analysis via the PLS-SEM approach was performed on 325 responses. This assessment was done on the measurement model as well as the structural model. The results of the study revealed that TV channel addiction among the respondents tends to result in parasocial relationships. Moreover, the moderation of parasocial relationships and mediation of emotional engagement were also found to be significant in the case of TV channels. On the contrary, the results did not reveal a significant relationship between YouTube channel addiction and parasocial relationships. Additionally, the moderation of parasocial relationships and mediation of emotional engagement were also not found significant. A more detailed result is presented in the corresponding sections, and future directions are also provided.
Circulating redox status in sheep infected with dermatophytes: a field study
Authors: Saleh Mostafa A. , Rateb M. H. , Abd-Allah Elham A. , Mohamed Ghada A.E. 
Published: March 2022

Abstract
Dermatophytosis is a zoonotic mycotic infection of the skin caused by dermatophytes. The present study aimed to evaluate the oxidative stress (OS) and redox status in blood of sheep clinically infected with the dermatophyte, Trichophyton verrucosum. According to clinical and mycological investigations, 48 juvenile male Balady sheep were selected in their natural habitat and divided into four groups depending on lesions size: mild (MID), moderate (MOD), severe T. verrucosum infection (SEV) and healthy control groups. Compared to the controls, plasma superoxide anion increased (P < 0.05) in both MOD and SEV but total peroxides (TPx) gradually increased (P < 0.05) in MID followed by MOD and SEV. Superoxide dismutase and total antioxidant capacity (TAC) were higher (P < 0.05) in MID and lower (P < 0.05) in MOD and SEV than in controls, but SEV showed lower TAC than MOD. Malondialdehyde (MDA, a lipid peroxide marker) increased (P < 0.05) in SEV than in controls but protein carbonyl (PC, protein peroxidation marker) was augmented (P < 0.05) as lesions progressed from mild to severe. oxidative stress index (TPx/TAC ratio) progressively increased (P < 0.05) in MOD and SEV. The correlation of PC was positive with TPx and negative with TAC (P < 0.01). In conclusion, sheep infection with T. verrucosum is characterized by increased TPx and decreased TAC in plasma depending on the lesion area. The redox status is shifted towards the oxidizing state especially in MOD and SEV cases resulting in a condition of OS, which may contribute to the pathogenesis of the disease.
An Enhanced Harris Hawk Optimization Algorithm for Parameter Estimation of Single, Double and Triple Diode Photovoltaic Models
Authors: Ramadan Abdelhady , Kamel Salah , Korashy Ahmed , Almalaq Abdulaziz , Domínguez-García Jose Luis 
Published: March 2022

Abstract
Due to the rapid development of photovoltaic (PV) system and spreading of its application, the accuracy of modelling of solar cells, as the main and basic element of PV systems, is gaining relevance. In this paper, an Enhanced Harris Hawk Optimization Algorithm (EHHO) is proposed and applied for estimating the required parameters of different PV models in an effective and accurate way. Harris Hawk Algorithm (HHO) is based on Hawks ways in hunting and catching their brays. The HHO utilizes two phases including exploration and exploitation. The main purpose of proposed enhancement is to improve the second phase of HHO. This enhancement is performed on the exploration phase by fluctuating towards or outwards the best optimal solution using sine and cosine functions. Both conventional and proposed algorithms are applied for single, double and triple diode PV models. In order to test the applicability and robustness of proposed algorithm, it is applied for estimating the parameters of different real PV systems and compared with other recent optimization algorithms. The results show that the proposed EHHO is more accurate than conventional HHO and other algorithms.
GluR2 may drive neuroinflammation and cognitive impairments following peripherally repeated lipopolysaccharide exposures
Authors: He Xue , Gao Yuzhu , Yin Xiaoyu , Wu Xinmiao , Ji Muhuo , Shen Jinchun 
Published: March 2022

Abstract
Neuroinflammation has been demonstrated to play a key role in the pathogenesis of many neurological and neuropsychiatric diseases. Lipopolysaccharides (LPS), an element of the cell envelope of gram-negative bacteria, could activate the innate immune system to induce neuroinflammation and eventually lead to cognitive impairments. Accumulating evidence has suggested the presence of glutamate receptors (GluRs) on glial cells can induce glial activation. Therefore, we hypothesized that repeated lipopolysaccharide exposures could increase GluR levels and mediate microglia activation, eventually contributing to synaptic plasticity and cognitive impairments. In the present study, C57/BL6 mice were subjected to repeated LPS exposures to establish the animal model of neuroinflammation. The levels of GluRs, inflammatory cytokines, ionized calcium binding adaptor molecule 1 (Iba1), postsynaptic density protein 95 (PSD-95), synaptophysin 38 (SVP38), NMDA receptor 2A (GluN2A), and GluN2B were determined in the hippocampi. The dendritic spine density was evaluated in the CA1 of the hippocampi. Our results showed that repeated LPS exposures induced cognitive impairments, increased the levels of GluR1 and GluR2 and induced microglia activation, which were accompanied by significantly decreased GluN2B expression and dendritic spine density in the hippocampi. However, AMPAR antagonist CFM-2 administration reversed these abnormalities. In addition, microglia inhibitor minocycline also reversed these abnormalities, downregulated GluR2 but not GluR1 expresssion. In conclusion, our study demonstrated that GluR2 may be an important contributor to microglia mediated-neuroinflammation, leading to synaptic plasticity and cognitive impairments induced by repeated LPS exposures.
Decline in Carbon Decomposition from Litter After Snow Removal is Driven by a Decreased Release of Carbohydrates
Authors: Zhu Jingjing , Wu Qiuxia , Wu Fuzhong , Yue Kai , Ni Xiangyin 
Published: March 2022

Abstract
Purpose
Winter snow cover is a key control over soil biogeochemical cycles in cold biomes but has decreased with climate warming, particularly in high-latitude and high-altitude areas. Previous studies have found a decline in carbon (C) release from decomposing litter without snow cover, yet partitioning of what C fractions in response to snow removal remains not fully understood.
Methods
Here we incubated fir and birch litter in microcosms over two years of decomposition in an alpine forest to assess the release of various C fractions with and without snow cover using 13C nuclear magnetic resonance (NMR).
Results
We found that 51% and 61% of total C were lost from fir and birch litter, respectively, after two years of decomposition, and 59% and 60% of these C were decomposed during winter time. More C was lost from both fir and birch litter under snow cover, and the decomposition rate of birch litter C was decreased by 50% after snow removal. However, only O-alkyl C (particularly carbohydrate C) release was reduced with snow removal, and the release of other C fractions (i.e., alkyl C, aromatic C and carbonyl C) did not change significantly after removing snow cover. Reduction in O-alkyl C release from fir and birch litter was in accordance with the declines in soil dissolved organic C, invertase activity and microbial respiration rate under removed snow plots.
Conclusion
We conclude that a reduction in winter snow cover regulates early decomposition of plant litter by controlling the rapid release of more labile C fractions in seasonally snow-covered ecosystems.
Ferroptosis Contributes to Hypoxic-Ischemic Brain Injury in Neonatal Rats: Role of the SIRT1/Nrf2/GPx4 Signaling Pathway
Authors: Li Chang , Wu Zi-Yi , Xue Hang , Gao Qiu-Shi , Zhang Ya-Han , Wang Chang-Ming , Zhao Ping 
Published: March 2022

Abstract
Aims
Hypoxic-ischemic brain injury (HIBI) often results in cognitive impairments. Herein, we investigated the roles of ferroptosis in HIBI and the underlying signaling pathways.
Methods
The ferrostatin-1(Fer-1) or resveratrol (Res) treatments were administered intracerebroventricularly 30 min before HIBI in 7-day-old rats. Glutathione peroxidase 4 (GPx4) expression, malondialdehyde (MDA) concentration, iron content, mitochondrial morphology and the expression of silent information regulator factor 2-related enzyme 1 (SIRT1) and nuclear factor erythroid-2-related factor 2 (Nrf2) were measured after HIBI modeling. Additionally, the weight ratio of left/right hemispheres and brain morphology were determined and Nissl staining was conducted to reflect brain damage. The Morris water maze test was used to assess cognitive function.
Results
At 24 h after HIBI, GPx4 expression was decreased and MDA concentration and iron content were increased in the hippocampi. HIBI led to mitochondrial atrophy, brain atrophy/damage, and resultant learning and memory impairments, which were alleviated by inhibiting ferroptosis using Fer-1. Furthermore, the upregulation of SIRT1 expression by Res treatment increased the expression of Nrf2 and GPx4, which in turn attenuated ferroptosis, reducing brain atrophy/damage and improving learning and memory abilities.
Conclusion
Our results demonstrated the occurrence of ferroptosis during HIBI via the SIRT1/Nrf2/GPx4 signaling pathway. Thus, this pathway represents a potential therapeutic target for the inhibition of ferroptosis and amelioration of HIBI-induced cognitive impairments.
Relationships between physical activity, healthy eating and cortical thickness in children and young adults
Authors: Angelo Brendan C , DeFendis Alexis , Yau Anita , Alves Jasmin M. , Thompson Paul M. , Xiang Anny H , Page Kathleen A. , Luo Shan 
Published: March 2022

Abstract
Prior neuroimaging studies have shown associations between healthy lifestyle factors and cortical thickness measurements; however, results on the direction of the association between cortical thickness, a measure of gray matter width, and healthy lifestyle factors have been inconsistent. While the majority of studies were performed in older adults within specific weight status categories, little has been reported in younger populations with a range of adiposity, including groups with healthy-weight, overweight and obesity. Here we investigated relationships between indices of physical activity (PA) and healthy eating with cortical thickness in children and young adults and examined whether these relationships differed by weight status and age groups. Study participants included 119 young adults and 159 children. We hypothesized that greater levels of PA and/or healthy eating index (HEI) composite scores would be positively associated with cortical thickness across age groups, and that this association would differ in overweight or obese groups versus normal weight groups. Overall PA (minutes/day) was assessed using 24-hour PA recalls. HEI was calculated to assess diet quality. A structural MRI was performed, and FreeSurfer 6.0 was used to assess cortical thickness in 68 regions of interest (ROI). Mixed effects modeling was performed to investigate associations of PA or HEI with cortical thickness. FDR corrections were applied for multiple ROIs. PA was positively associated with cortical thickness in the caudal middle frontal cortex (FDR adjusted p = 0.042) and cuneus cortex (FDR adjusted p = 0.017), after controlling for sex, age group and weight status. When stratified by age, in young adults, higher time spent in PA was associated with greater cortical thickness in the frontal, temporal, parietal and occipital cortex, after adjusting for sex and weight group (FDR adjusted ps < 0.05). No significant associations between PA and cortical thickness were observed in children. No significant associations between HEI and cortical thickness were observed. These results indicate that higher time spent in PA is associated with greater cortical thickness, a relationship that appears to be stronger during young adulthood and may be related to more favorable brain health outcomes.
Pan-Cancer Analysis of Kinesin Family Member 2C (KIF2C) in Human Tumors
Authors: Zhang Bixi , Li Yanchun , Gong Siming , Duan Yingjuan , Xu Meihua , Xu Canxia , Wu Hao 
Published: March 2022

Abstract
Kinesin family member 2C (KIF2C) is the best-characterized member of the kinesin-13 family and is involved in accurately fine-tuned dynamics of mitotic spindles. As KIF2C is involved in both spindle formation and regulation of DNA double-strand breaks, precise regulation of KIF2C is essential to prevent malignant transformation associated with gains and losses of DNA content. In the present study, we initially reviewed The Cancer Genome Atlas database and observed that KIF2C is abundantly expressed in most tumor types. We then analyzed the gene alteration profile, protein expression, prognosis, and immune reactivities of KIF2C in more than 10,000 samples from several well-established databases. In addition, we conducted a gene enrichment set analysis to investigate the potential mechanisms underlying the role of KIF2C in tumorigenesis. Pan-cancer analysis of KIF2C demonstrated significant statistical correlations between KIF2C expression and clinical prognosis, oncogenic signature gene sets, myeloid-derived suppressor cell infiltration, ImmunoScore, immune checkpoints, microsatellite instability, and tumor mutational burden across multiple tumors. The findings of this study provide important insight for understanding the role and mechanisms of KIF2C in tumorigenesis and immunotherapy and its clinical progression in a variety of cancers.
On Mann Implicit Composite Subgradient Extragradient Methods for General Systems of Variational Inequalities with Hierarchical Variational Inequality Constraints
Authors: Shehu Yekini , Ceng Lu-Chuan , Yao Jen-Chih 
Published: March 2022

Abstract
In a real Hilbert space, let the VIP, GSVI, HVI and CFPP denote a variational inequality problem, a general system of variational inequalities, a hierarchical variational inequality and a common fixed-point problem of a countable family of uniformly Lipschitzian pseudocontractive mappings and an asymptotically nonexpansive mapping, respectively. We design two Mann implicit composite subgradient extragradient algorithms with line-search process for finding a common solution of the CFPP, GSVI and VIP. The suggested algorithms are based on the Mann implicit iteration method, subgradient extragradient method with line-search process, and viscosity approximation method. Under mild assumptions, we prove the strong convergence of the suggested algorithms to a common solution of the CFPP, GSVI and VIP, which solves a certain HVI defined on their common solutions set.
Ross operation in pediatric population: impact of surgical timing and the native pulmonary diameter on the outcome.
Authors: Varrica Alessandro , Giamberti Alessandro , Rito Mauro Lo , Reali Matteo , Hafdhullah Mahmood , Satriano Angela , Saracino Antonio , Micheletti Angelo , Frigiola Alessandro 
Published: March 2022

Abstract
Background: Aortic valve replacement early in life maybe inevitable at times. Ross operation until present-day remains the favorite surgical option in pediatrics with irreparable aortic valve disease. Nonetheless the necessity for re-operation was always its principal limitation due to aortic valve failure or homograft degeneration. We hereby present our 25 years of experience in pediatric population.Methods: From August 1994 until June 2018, a total of 157 children below 18 years underwent a Ross operation. This retrospective review aims at assessing long-term outcome likewise risk factors for re-operation after Ross procedure.Results: Median age was 10.9 years, of which 7 were infants, 79 children and 71 adolescents. Median follow-up was 14 years. Hospital mortality was 0.6%. Freedom from autograft re-operation for children was 96.7% and 94.1% at 10 and 20 years respectively, whereas for adolescents it was 92.6% and 74.9% at 10 and 20 years. For children freedom from homograft re-operation was 92.5%, 83.5% and 56.2% at 10, 15, and 20 years respectively. While for adolescents, it was 96.8%, 91.8%, and 86.7% at 10, 15, and 20 years. Homograft size (p=0.008) and childhood (p=0.05) were risk factors for homograft re-operation. Pulmonary valve diameter >24 mm (p=0.044) and adolescence (p=0.032) were risk factors for autograft re-operation.Conclusions: Our experience demonstrated excellent early and late survival. Whilst children have preferential outcomes concerning autograft re-operation, those who received a smaller homograft had higher incidences of right-sided re-intervention compared to adolescents. Pulmonary diameter >24mm at surgery was an indicator for future autograft failure.