bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effectiveness of a specific physical therapy program for Charcot-Marie-Tooth on sleep quality, pain perception, and nocturnal cramps: a pilot study
Authors: Souza Cynthia Coelho , Vallim Julia Ribeiro da Silva , Neves Eduardo Luis de Aquino , Nunes Paula Santos , Costa Iandra Maria Pinheiro de França , Barreto Lidiane Carine Lima Santos , Garcez Catarina Andrade , Araujo Adriano Antunes de Souza 
Published: September 2022

Introduction Chronic pain, nocturnal cramps, and sleep alterations are prevalent symptoms and signals in Charcot-Marie-Tooth disease patients. Sleep and pain are bidirectionally related and physical therapy can improve the binomial sleep and pain/nocturnal cramps. Therefore, we hypothesized that the application of a specific physical therapy program for Charcot-Marie-Tooth disease would improve sleep quality, pain perception, and nocturnal cramps.
Material and Methods A non-randomized controlled study that included 9 Charcot-Marie-Tooth disease patients (intervention group - physical therapy program) and 8 controls (active control group - booklet on sleep hygiene). The intervention lasted 8 weeks, three sessions per week. The effects were evaluated ten days before (baseline) and ten days after the intervention (post). Our primary outcome was sleep quality (subjective and objective, assessed by Pittsburgh sleep quality index and actigraphy, respectively); and secondary outcomes were pain perception (brief pain inventory) and nocturnal cramps (self-report).
Results The program was able to improve the subjective sleep quality (p=0.005) and nocturnal cramps (p<0.001) but had no effect on actigraphy data (p>0.05) neither on pain perception (p>0.05).
Conclusion Our initial hypothesis was partially corroborated: the improvement in subjective quality of sleep and nocturnal cramps is already beneficial for the health promotion of the volunteers in this study affected by the disease. Our findings may serve as a basis for future research to develop a program focused on the treatment of analgesia, which can improve pain perception and alter the objective quality of sleep.
Insomnia in older HIV-positive patients
Authors: Salles Cristina , Cruz Miguel Meira e , Freire Igor Cardoso , Gonzaga Lucas Haine , Dias Cristiane Costa 
Published: September 2022

Introduction Insomnia is a common sleep disorder in elderly. Although the HIV-positive population have a similar life expectancy when compared to the general population, some factors may interact with immunity conditions and therefore contribute to a worse prognosis.
Objective This is a review of literature that aims to identify prevalence of insomnia in older HIV-positive patients.
Material and Methods This is a review of literature conducted by using MEDLINE-PubMed, Embase, Cochrane Library, CINAHL, Web of Science, Scopus, SciELO, LILACS, and VHL databases, in addition to conducting manual searches. The terms used for the search were related to prevalence, HIV, insomnia, and advanced age. Inclusion criteria were: cross-sectional, cohort, and longitudinal studies, patients with a previous diagnosis of HIV in old age, studies reporting the frequency of insomnia or insomnia symptoms. The criteria for exclusion were: clinical trials, animal studies, letters, abstracts, conference proceedings, studies with other sleep scales that did not include insomnia.
Results There were 2,805 publications found in the database and a further 10 articles were included manually. Of this total, four were included in this review, resulting in a total of 2,227 participants. The prevalence of insomnia in HIV-positive patients over 50 years varied from 12.5% to 76.5%.
Conclusion The frequency of insomnia was higher in the profile of the population studied than in the general population. This should be clinically relevant in order to adequately treat and impact on the prognosis of those patient.
Porphyrin‐based Donor–Acceptor Covalent Organic Polymer/ZnIn2S4 Z‐Scheme Heterostructure for Efficient Photocatalytic Hydrogen Evolution
Authors: Cui Chao , Zhao Xiaolei , Su Xiaowen , Xi Ning , Wang Xiaoning , Yu Xiaowen , Zhang Xiao Li , Liu Hong , Sang Yuanhua 
Published: September 2022

AbstractThe construction of a Z‐scheme photocatalytic system is significant in realizing efficient water splitting for hydrogen (H2) evolution. Herein, a novel donor–acceptor covalent organic polymer (COP) is introduced to construct a COP‐ZnIn2S4 (ZIS) heterostructure via in situ condensation reaction. The COP‐ZIS heterostructure with platinum (Pt) as cocatalyst delivers a high hydrogen evolution rate of 5.04 mmol g−1 h−1, which is 16 and 3 times higher than ZIS and Pt/ZIS, respectively. The built‐in field between the highest occupied molecular orbital of COP and the valence band (VB) of ZIS forms a Z‐scheme heterostructure, realizing efficient charge separation. Based on density functional theory calculations, the porphyrin molecule in COP act as electron donor that provides compensating electrons to ZIS. The cocatalyst boosts the utilization of electrons in ZIS. The rate‐limiting steps for H2 evolution with ZIS are overcome by improving charge separation with the Z‐scheme heterostructure and speeding up the reaction with cocatalyst. Therefore, the COP‐ZIS heterostructure with Pt exhibits optimized H2 evolution. This study will inspire to construct novel organic and inorganic Z‐scheme photocatalysts for efficient green energy production.
An Activity‐Based Photosensitizer to Reverse Hypoxia and Oxidative Resistance for Tumor Photodynamic Eradication
Authors: Shi Leilei , Zhang Peng , Liu Xiaoxiao , Li Yuzhen , Wu Wenbo , Gao Xihui , Liu Bin 
Published: September 2022

AbstractPhotodynamic therapy (PDT) has been a well‐accepted clinical treatment for malignant tumors owing to its noninvasiveness and high spatiotemporal selectivity. However, the treatment outcome of current PDT applications is hindered by hypoxia and intracellular oxidative resistance of solid tumors. Recent studies have shown that inhibiting histone deacetylases (HDACs) can induce cell ferroptosis, reverse hypoxia, and elevate oxidative status. Theoretically, the design and synthesis of activity‐based photosensitizers that target HDACs can address the bottlenecks of PDT. Herein, the concept of an activity‐based photosensitizer is presented for targeting HDACs, which is designed based on a quinoxalinone scaffold through a pharmacophore migration strategy. The developed activity‐based photosensitizer can inhibit HDACs, and overcome hypoxia and intracellular oxidative resistance, realizing the full potential of photosensitizers for malignant tumor treatment. The molecular design strategy proposed in this project should provide theoretical guidance for the development of ideal photosensitizers for practical applications.
Stable Correlated 4d2 SrMoO3 Films Epitaxially Coated on Al2O3 for Electromagnetic Shielding and Transparent Conductors
Authors: Ha Youngkyoung , Lee Shinbuhm 
Published: September 2022

AbstractCorrelated perovskites have attracted significant attention worldwide for their potential application in transparent conductors. However, most studies in this area have focused on single‐crystalline films grown on expensive perovskites. In this study, the transparent conducting properties of SrMoO3 epitaxial films grown on Al2O3, the most commonly used substrate for optoelectronics, are investigated. The 45−80‐nm‐thick SrMoO3 epitaxial films on ‐oriented Al2O3 exhibit low sheet resistance (< 50 Ω □−1) at room temperature and high ultraviolet‐visible transmittances (> 60%), comparable with the values expected from single‐crystalline films. The highly conductive properties induced by two electrons in the outermost 4d orbitals guarantee a high electromagnetic shielding effectiveness of approximately 28.5 dB at 10 GHz in the X‐band. The SrMoO3 films are thermally stable below 450 °C in air and 700 °C in vacuum. Taken together, these results indicate that SrMoO3 epitaxial films grown on Al2O3 can be highly promising for optoelectronic applications in extreme environments.
Thermoresponsive Polymer Brushes for Switchable Protein Adsorption via Dopamine‐Assisted Grafting‐To Strategy
Authors: Teunissen Lucas W. , van den Beukel Jelle , Smulders Maarten M. J. , Zuilhof Han 
Published: September 2022

AbstractSurface modifications using responsive polymers give access to biomedical applications that rely on switchable properties, such as smart sensors and actuator systems. In this work, thermoresponsive polymer coatings are synthesized on silicon oxide surfaces using a facile and effective two‐step grafting‐to strategy. Briefly, the substrates are first functionalized with a poly(dopamine) (poly(DA)) primer layer. Subsequently, block copolymers of poly(glycidyl methacrylate) and poly(N‐isopropylacrylamide) (poly(GMA)20‐block‐poly(NIPAM)n (n = 263, 528 and 705)) synthesized via reversible addition‑fragmentation chain‑transfer (RAFT) polymerization, are grafted to the poly(DA)‐modified surfaces. Characterization using ellipsometry, X‐ray photoelectron spectroscopy (XPS) and contact angle measurements confirmed polymer attachment with appreciable grafting densities. Quartz crystal microbalance with dissipation monitoring (QCM‐D) is employed to investigate the thermoresponsive properties and degree of hydration of the polymers below and above their lower critical solution temperature (LCST). The longer the polymer chain, the more water is lost per repeating unit upon increasing the temperature above the LCST. The surfaces are exposed to diluted and undiluted human serum at 20 °C and 40 °C to demonstrate for all three polymer brushes switchable protein adsorption‐repellence. In a broader perspective, this study presents a straightforward, robust and efficient procedure to modify virtually any surface type with a thermoresponsive coating.
Flexible Conducting Polymer Electrodes for Selective Stimulation of Small Sensory Fibers in Humans
Authors: Velasco‐Bosom Santiago , Gurke Johannes , Han Sanggil , Lee Michael C. , Malliaras George G. 
Published: September 2022

AbstractSmall‐fiber neuropathy (SFN), a pathology caused by severe loss of free‐endings of unmyelinated sensory nerves, is difficult to diagnose and monitor. The use of cutaneous electrical stimulation as a diagnostic tool is hampered by the fact that the injected current penetrates deep into the skin and stimulates many other receptors. Interdigitated electrodes are recently proposed to control the depth of current penetration and selectively address small‐fibers. Here, flexible and adhesive interdigitated electrodes made of Au coated with poly(3,4‐ethylenedioxythiophene) polystyrene sulfonate (PEDOT:PSS) are developed, that conform comfortably and reliably to human skin. It is shown that the PEDOT:PSS coating improves safety by significantly reducing the voltage required to inject current. The selectivity of the device is assessed by showing that it elicits a significantly slower reaction time than commercial cutaneous electrophysiology electrodes, as it exclusively activates unmyelinated fibers. The device is further evaluated on volunteers that undergo local capsaicin treatment to induce temporary loss of the nerve endings of small‐fibers. Pre‐ and post‐treatment electrical stimulation of the affected area with the device reveals impaired sensory detection that is not observed with commercial cutaneous electrophysiology electrodes. These results represent a significant step towards the use of electrical stimulation as a diagnostic and monitoring tool for SFN.
Enhanced Light–Tellurium Interaction through Evanescent Wave Coupling for High Speed Mid‐Infrared Photodetection
Authors: Ma Hui , Wu Jianghong , Wang Yunpeng , Zhong Chuyu , Ye Yuting , Wei Maoliang , Yu Rui , Du Yiqing , Tang Bo , Sun Cheng , Shi Yilin , Sun Chunlei , Wang Lichun , Zhu Haiming , Qiao Xvsheng , Li Lan , Lin Hongtao 
Published: September 2022

AbstractMid‐infrared (MIR) waveguide‐integrated photodetector is essential for various applications in the fields of sensing and optical communications. However, it is challenging to integrate traditional MIR photoactive materials such as HgCdTe or III−V compounds with complementary metal‐oxide‐semiconductor (CMOS)‐compatible silicon platform due to the lattice mismatch. Tellurium (Te), a novel van der Waals (vdW) material with a narrow bandgap, high carrier mobility, and great air stability, is a promising candidate for high‐performance MIR detection. Here, high‐quality Te nanosheets are synthesized using a hydrothermal method and their carrier dynamics are characterized by transient reflection spectrum. The effect of mobility anisotropy on response speed is investigated intuitively by a free space phototransistor. Combining the strong evanescent wave of a waveguide architecture with the synergy effect between the carrier collection path and the highest mobility crystal orientation in Te, an integrated Te photodetector with enhanced light–matter interaction and reduced carrier transit time is achieved. For the first time, the MIR waveguide‐integrated Te photodetector with a responsivity of 2.3 A W−1 and a bandwidth of 4 GHz at 2015 nm is realized, which is the highest speed MIR photodetector based on narrow bandgap vdW materials to date.
One‐Step Exfoliation Method for Plasmonic Activation of Large‐Area 2D Crystals
Authors: Fu Qiang , Dai Jia‐Qi , Huang Xin‐Yu , Dai Yun‐Yun , Pan Yu‐Hao , Yang Long‐Long , Sun Zhen‐Yu , Miao Tai‐Min , Zhou Meng‐Fan , Zhao Lin , Zhao Wei‐Jie , Han Xu , Lu Jun‐Peng , Gao Hong‐Jun , Zhou Xing‐Jiang , Wang Ye‐Liang , Ni Zhen‐Hua , Ji Wei , Huang Yuan 
Published: September 2022

AbstractAdvanced exfoliation techniques are crucial for exploring the intrinsic properties and applications of 2D materials. Though the recently discovered Au‐enhanced exfoliation technique provides an effective strategy for the preparation of large‐scale 2D crystals, the high cost of gold hinders this method from being widely adopted in industrial applications. In addition, direct Au contact could significantly quench photoluminescence (PL) emission in 2D semiconductors. It is therefore crucial to find alternative metals that can replace gold to achieve efficient exfoliation of 2D materials. Here, the authors present a one‐step Ag‐assisted method that can efficiently exfoliate many large‐area 2D monolayers, where the yield ratio is comparable to Au‐enhanced exfoliation method. Differing from Au film, however, the surface roughness of as‐prepared Ag films on SiO2/Si substrate is much higher, which facilitates the generation of surface plasmons resulting from the nanostructures formed on the rough Ag surface. More interestingly, the strong coupling between 2D semiconductor crystals (e.g., MoS2, MoSe2) and Ag film leads to a unique PL enhancement that has not been observed in other mechanical exfoliation techniques, which can be mainly attributed to enhanced light‐matter interaction as a result of extended propagation of surface plasmonic polariton (SPP). This work provides a lower‐cost and universal Ag‐assisted exfoliation method, while at the same time offering enhanced SPP‐matter interactions.
Anionic Coordination Manipulation of Multilayer Solvation Structure Electrolyte for High‐Rate and Low‐Temperature Lithium Metal Battery
Authors: Sun Nannan , Li Ruhong , Zhao Yue , Zhang Haikuo , Chen Jiahe , Xu Jinting , Li Zhendong , Fan Xiulin , Yao Xiayin , Peng Zhe 
Published: September 2022

AbstractChallenges from high‐energy‐density storage applications have boosted the pursuit of designing high‐rate and low‐temperature lithium (Li) metal batteries (LMBs). Formulating high‐concentration electrolytes (HCEs) with a high transference number (t+) is an alternative solution to satisfy these demands. However, the implementation of HCEs is impeded by their lower ionic conductivity, higher viscosity, poorer wettability, and higher melting point, which are harmful to the practical applications. Herein, an anionic coordination manipulation strategy is proposed to break the constraints presented by HCEs. By manipulating the anionic species with different coordinating abilities, a high t+ up to 0.9 can be achieved even in the low‐concentration electrolytes of 1 mol L−1. By further forming a multilayer solvation structure in the anion manipulated electrolyte using non‐polar diluents, high Li Coulombic efficiency superior to 99% can be maintained under a high current density of 3 mA cm−2, and much‐improved performance is also demonstrated in high‐loading Li metal pouch cells. Furthermore, when applying multilayer solvated structure in electrolyte engineering, Li metal anodes at subzero temperature and LMBs at 0 °C also exhibit impressive cycling stability. This work provides a new guideline for designing advanced electrolytes for high‐rate LMBs under practical conditions.
Amyloid fibrils act as a reservoir of soluble oligomers, the main culprits in protein deposition diseases
Authors: Bigi Alessandra , Cascella Roberta , Chiti Fabrizio , Cecchi Cristina 
Published: September 2022

AbstractAmyloid fibril formation plays a central role in the pathogenesis of a number of neurodegenerative diseases, including Alzheimer and Parkinson diseases. Transient prefibrillar oligomers forming during the aggregation process, exhibiting a small size and a large hydrophobic surface, can aberrantly interact with a number of molecular targets on neurons, including the lipid bilayer of plasma membranes, resulting in a fatal outcome for the cells. By contrast, the mature fibrils, despite presenting generally a high hydrophobic surface, are endowed with a low diffusion rate and poorly penetrate the interior of the lipid bilayer. However, increasing evidence shows that both intracellular α‐synuclein fibrils, as well and as extracellular amyloid‐β and β2‐microglobulin fibrils, can release oligomers over time that quickly diffuse to reach the membrane of the neighboring cells. The persistent leakage of harmful oligomers from fibrils triggers an ongoing cascade of events resulting in a sustained injury to neurons and glia and also provides aggregates with the ability to cross biological membranes and diffuse between cells or cellular compartments.
The relationship between the subclavian vessels and brachial plexus and the overlying clavicle: Anatomical study with application to plate osteosynthesis
Authors: Schmiedl Andreas , Buchhorn Andreas , Schönberger Michael 
Published: September 2022

AbstractA subclavian artery aneurysm after clavicle fracture and plate osteosynthesis in a suspected case of a screw that was too long led us to investigate body donor cadavers. The aim was to verify clavicle variability, and the course of the neurovascular bundle in relation to the clavicle and to the osteosynthesis plate, in order to clarify safe zones for plate and screw fixation. We used one fresh frozen and 25 embalmed donors for in situ measurements: (1) length and craniocaudal thickness of the clavicle, (2) distances between the sternal end of the clavicle and the center of parts of the neurovascular bundle. The clavicle was 15.15 cm long. The mean distances from the sternal end of the clavicle were 5.62 cm to the subclavian vein, 6.75 cm to the subclavian artery and 8.42 cm to the cords of the brachial plexus. The subclavius muscle was 1 cm thick. Because of sex differences in length and distances, we recorded the distances between the sternal end and parts of the neurovascular bundle as ratios of clavicle length (at‐risk area) to provide sex‐independent parameters: 0.379 for the vein, 0.449 for the artery and 0.554 for the nerve. The neurovascular bundle runs below the clavicle between the medial fourth and three fifths of clavicle length. To avoid iatrogenic neurovascular injuries, special caution is necessary during drilling and screwing the osteosynthesis. We also recommend using screws shorter than 1.4 cm.
UHPLC‐ESI‐QTOF‐MS/MS Based Identification, Quantification, and Assessment ofin SilicoMolecular Interactions of Major Phytochemicals from Bioactive Fractions ofClerodendrum glandulosumLindl. Leaves
Authors: Kumar Deb Prashanta , Shilkar Deepak , Sarkar Biswatrish 
Published: September 2022

AbstractClerodendrum glandulosumLindl., is an ethnopharmacologically important species of the North‐eastern region of India. Leaves of this plant are consumed as food and traditionally used as medicine to cure hypertension, diabetes, and other metabolic syndromes. This study was designed to explore the antioxidant potential in theClerodendrumleaves guided byin‐vitroactivity, which is responsible for the therapeutic benefits. Leaves were extracted with 95 % methanol and further fractionated with solvents of varying polarities (e. g., petroleum ether, ethyl acetate, and butanol). Total phenolic and total flavonoid content of the crude extract/ fractions were measured by Folin‐Ciocalteu and AlCl3methods, respectively. Crude extract/ fractions were screen forin‐vitroantioxidant and cytoprotective activities to determine the most bioactive fraction. Simultaneously, the chemical constituents of these fractions were identified and characterized using UHPLC‐ESI‐QTOF‐MS/MS. Subsequently, major phenolic compounds identified were subjected toin‐silicomolecular docking with pro‐oxidant enzymes to elucidate possible biological functions. Both ethyl acetate and butanol fractions showed the presence of a high concentration of phenolic and flavonoid content along with the best antioxidant and cytoprotective properties compared to all other fractions. Chemical profiling of these active fractions revealed the presence of different phenolic compounds, among which verbascoside was the principal compound. These major phytoconstituents also exhibited strong binding interactions with the crucial amino acid residues of the target proteins, which complemented thein‐vitrobioactivities. In conclusion, this study offers structured information on antioxidant phytochemicals present inC. glandulosumleaves, which would be worthwhile for future investigations on the therapeutic properties at the molecular level.
Comprehensive study on gluten composition and baking quality of winter wheat
Authors: Schuster Clemens , Huen Julien , Scherf Katharina Anne 
Published: September 2022

AbstractBackground and ObjectivesProtein and gluten content and composition are important for the baking quality of wheat flours. Our aim was to provide a comprehensive characterization of 82 wheat flours to analyze the influence of protein composition on rheological and baking quality parameters.FindingsProtein composition, starch gelatinization behavior, as well as rheological (microfarinograph, gluten aggregation, extensibility), and baking parameters were determined. The correlation matrix showed no significant correlations between gluten composition and loaf volume. Parameters of the gluten aggregation test allowed a prediction of gluten, gliadin, and glutenin content with an absolute root mean square error of cross validation of 7.5, 6.0, and 3.2 mg/g, respectively, using partial least squares regression. Starch gelatinization temperature had an effect on gluten aggregation.ConclusionsThe gluten aggregation test was suitable to predict gluten, gliadin, and glutenin content. The lack of correlations between protein composition and loaf volume indicates that baking quality is the result of a complex combination of different parameters.Significance and NoveltyOur study is the first to comprehensively analyze 82 wheat flours, especially in terms of gluten composition. We show that flour blends can reach excellent baking quality even if quality indicators like crude protein or extensibility are comparatively low.