bluuebunny/crossref_metadata_2025_split huggingface dataset:
Insider Threat Detection: A Novel Approach Combining User Behaviour Trust Evaluation and Fuzzy Recommendations
Authors: Wu Zenan , Zhang Tiancai , Tian Liqin , Bai Zhangxuan , Dong Yuejun , Wang Yan 
Published: February 2025

Abstract

Insider threats can cause significant damage to a business or organisation, and insider threat detection is critical to maintaining the security of vital corporate information. By evaluating and monitoring the behaviours of visiting users, abnormal behaviours, unusual activities or potential threatening behaviours can be detected at an early stage, which will help to improve the identification of insider threats in a business/organisation and to take effective measures to deal with potential risks. Existing insider threat detection methods rely more on predefined rules, require explicit feature engineering, and generate more false positives.To overcome these limitations, the focus of the work proposed in this paper is to introduce an enhanced insider threat detection method based on credible assessment of user behaviour. It enables fewer false positives, faster threat detection, and significantly higher classifier accuracy. This enhancement is achieved due to the fact that: firstly, the model contains both a direct and an indirect assessment module, and ensures the dynamics of the assessment by balancing the factors; furthermore, the model optimises the balance of the subjective and objective weights in the direct assessment module, which effectively solves the impact of the unequal distribution of the subjective and objective weights on the assessment results; and, based on the trust recommendation of the user by the service provider of a comparable system, the user is evaluated by using a fuzzy Petri net to assess the indirect trust attributes of the user. Finally, the model was tested on the CMU-CERT v4.2 dataset using four different performance evaluation metrics, and compared and analysed with existing evaluation models. The test results show that the model has higher accuracy for untrustworthy user detection and better applicability of the model.
Awareness of HIV, HPV, and Gonorrhea, and acceptance of vaccines against them, among displaced persons and their host communities in Bangladesh
Authors: Rego Ryan T. , Barman Ashok K. , Wagner Abram , Carlson Bradley , Boulton Matthew L. , Rana Gurpreet K. , Watson Samuel I. , Raqib Rubhana , Lee Haeun , Waljee Akbar K. , Islam Md. Sirajul 
Published: February 2025

Abstract

Introduction
New vaccines are forthcoming for various diseases, including sexually transmitted infections (STIs). Acceptance by populations is critical for vaccine programs. Considering the ever-increasing number of displaced people globally, given conflict and climate change, displaced populations and their host communities are key but under-studied groups. We examined the acceptance of the current Human Papilloma Virus (HPV) vaccine and hypothetical Human Immunodeficiency Virus (HIV), and Gonorrhea vaccines, as well as awareness of these STIs among displaced populations and their host communities in Bangladesh.
Methods
The study, conducted between September 2022 and February 2023, examined four groups: forcibly displaced Myanmar nationals in Teknaf; the host community of Bangladeshi citizens living in Teknaf; climate internally displaced people in Dhaka; and the host community of permanent residents in Dhaka. We aimed to randomly recruit 400 households per group. Participants were asked for consent and screened for eligibility. Once consented, a survey was administered, which measured: 1) household composition, 2) demographics, 3) healthcare use, 4) perspectives on government policy and neighborhood dynamics, and 5) STI awareness and vaccine hesitancy. Data were analyzed using bivariate and multivariate analyses.
Results
Overall 1,617 respondents were included. Disease knowledge was low - 34[95%CI(31.7,36.3)]% had heard of HPV, 50[95%CI(47,53)]% had heard of HIV, and 5[95%CI(4,6)]% had heard of gonorrhea. Awareness varied by group - with the displaced populations generally having less awareness than their host communities; and those in Dhaka having higher awareness than those in Teknaf. Covariates associated with awareness include gender, with women more likely to be aware of STIs than men; education, with those with tertiary education more likely to be aware of HPV than those with below primary education; and watching TV - with watching TV increasing awareness of HIV and HPV. Almost all respondents reported willingness to be vaccinated against each STI.
Conclusions
Despite the low awareness of STIs, acceptance of STI was high. This presents a promising opportunity for reducing the burden of STIs, however it calls for increasing educational activities to increase deeper knowledge on various STIs.
Intravenous streptozotocin induces variants in painful diabetic peripheral neuropathy in female mice
Authors: Hagenimana Michelle , Green Audrey R. , Tierney Jessica A. , Lenert Melissa E. , Burton Michael D. 
Published: February 2025

Abstract

Purpose: At least half of the 34 million diabetic patients in the U.S. develop painful diabetic peripheral neuropathy (DPN). Recent evidence suggests that there are sex differences in the prevalence and mechanisms underlying pathological pain states. However, due to technical limitations in murine models, there is a dearth of the use of females in diabetic neuropathy research. There is a need to develop a reproducible model to induce painful DPN in both sexes. The predominately used model employs streptozotocin (STZ) administration via intraperitoneal injections. This strategy consistently induces diabetic pathology in males, but not females. We set out to enhance a current murine DPN model by identifying a method for inducing diabetic pathologies in male and female mice and tracking the development of painful neuropathy.
Methods: Painful DPN was induced in both male and female mice through five daily intravenous injections of STZ. Metrics of diabetic pathology and pain behaviors were assessed across the development of painful DPN. To investigate neuronal sensitivity, calcium imaging assessing dorsal root ganglia neurons was performed.
Results: We found that after intravenous administration of STZ, both male and female mice exhibited elevated blood glucose levels, impaired glucose tolerance, and increased mechanical and thermal hypersensitivity. Interestingly, we observed a subset of STZ-insensitive animals that displayed comparable elevated glucose levels to the STZ-sensitive animals. Calcium imaging was performed to investigate neuronal sensitivity and we found that both male and female mice with diabetic pathology had a lower latency to peak capsaicin-induced response compared to their control counterparts.
Conclusion: Our findings demonstrate that intravenous administration of STZ can induce comparable diabetic neuropathy in male and female mice and opens the door for future preclinical studies on diabetic neuropathy.
Sensitivity of flood-prone areas to extreme rainfall using AHP and fuzzy AHP: a case study of Boussellam and K'sob watersheds, Algeria
Authors: Benaiche Morad , Mokhtari Elhadj , Berghout Ali , Abdelkebir Brahim , Engel Bernard 
Published: February 2025

ABSTRACT

Mapping flood-prone areas’ sensitivity to extreme rainfall is crucial for disaster risk reduction. Using the analytical hierarchy process (AHP) and fuzzy AHP methods with Geographic Information Systems (GIS) data, including factors like slope, elevation, precipitation, land use, and vegetation indices, enhances disaster preparedness. This approach enables creating maps that support informed decision-making for community resilience. In this study, AHP and fuzzy AHP models were applied across different return periods (2, 5, 10, 100, and 1,000 years) and average annual rainfall, revealing that high-risk areas vary by model: the AHP model showed high susceptibility in 2.19–25.55% of the area, while the fuzzy AHP model identified 1.53–24.51% as very sensitive. These risks are concentrated in the low-slope zones of the Boussellam and K'sob watersheds, posing a threat to three out of four nearby cities for 100-year or longer events.
Opioid Use Disorders: Prevention, Diagnosis, and Treatment Strategies to Mitigate Addiction Risks
Authors: Agarwal Uma , Singhal Khushboo , Tonk Rajiv Kumar 
Published: February 2025

Abstract:
Opioid Use Disorder (OUD) is defined by the persistent use of opioids despite adverse
consequences. It is associated with increased mortality and a variety of mental and general
medical comorbidities. Risk factors include younger age, male sex, lower educational attainment,
lower income, and psychiatric disorders, such as other substance use disorders and mood
disorders. Genetics also play a role in susceptibility to opioid use disorders. Long-term selfefficacy
in opioid use for non-medical purposes suggests irreversible opioid use disorders.
To evaluate the current understanding of opioid use disorders, the limitations in existing treatment
approaches were examined, and strategies to improve outcomes through expanded treatment
access and personalized care interventions were identified.
An analysis was carried out regarding the role of existing pharmacological treatments, barriers
within the care cascade, and potential advancements in healthcare delivery and innovation was
carried out to address opioid use disorders. A comprehensive review of the literature was conducted
by searching electronic databases (e.g., PubMed, Scopus) for articles published over the
past 20-25 years. Relevant studies were selected based on predefined inclusion criteria, focusing
on OUD risk factors, pharmacological treatments, barriers in the care cascade, and strategies for
improving care. The selection process prioritized systematic reviews, clinical trials, and key
guidelines.
Although medications for opioid use disorders are effective, their impact is hindered by systemic
issues at multiple levels of care. Addressing these challenges requires comprehensive efforts, including
professional training, innovative treatments, and healthcare reforms to expand access
and personalize care.
Atractylenolide I Inhibits the Growth of Esophageal Cancer Cells by Inhibiting the Wnt/Β-Catenin Pathway
Authors: Lian Maowei , Zhang Yunxiang , Li Xu , Niu Na , Tang Dong , Cao Lihua , Li Yong , Xiang Xiaocong , Yu Chunlei 
Published: February 2025

Background:
Esophageal cancer is a highly lethal cancer with a rapidly increasing incidence and a
poor prognosis. Atractylenolide I is a natural sesquiterpene lactone extracted from the rhizome of the Asteraceae
plant, which has a variety of pharmacological effects, such as anti-inflammatory and immunomodulatory. Still, its
impact on esophageal cancer has not been reported. Therefore, this study investigated the in vitro and in vivo
effects of Atractylenolide I on the growth and proliferation of esophageal cancer and explored its possible mechanisms.

Methods:
To evaluate the effect of atractylenolide I on esophageal cancer cells, apoptosis assay and cell cycle
assay tests were performed. Atractylenolide I was used to treat esophageal cancer cells for 48 hours, and flow
cytometry detects apoptosis and cell cycle. The Wnt/β-catenin-related pathway proteins were then detected by
Western blotting. For in vivo studies, an esophageal cancer graft tumor model was established subcutaneously in
BALB/c nude mice, which were given Atractylenolide I treatment for 2 weeks.

Result:
The result shows that Atractylenolide I inhibited the proliferation and induced apoptosis of esophageal
squamous carcinoma and adenocarcinoma cells. Further research shows that Atractylenolide I inhibited the
Wnt/β-catenin signaling pathway, decreased the expression of CCND1, MYC, and FN1 genes, and thus increased
the apoptosis of esophageal cancer cells and blocked the cell cycle in G0/G1 phase, hence exerting the role of
inhibiting esophageal cancer cells in vivo and in vitro.

Conclusion:
This study indicates that Atractylenolide I is an efficient lead compound for the treatment of esophageal
cancer, providing a theoretical basis for further clinical development and application of Atractylenolide I.
Clinical and In vitro Data Shed New Light on the Therapeutic Advantages of Black Seeds (Nigella sativa) for the Treatment of Hepatitis C and Hepatitis B Viral Infections
Authors: Maideen Naina Mohamed Pakkir , balasubramanian Rajkapoor , Balasubramanian Kumar , Hussain Mohamed Harsath Jahir , Shahul Hameed Mohamed Fahath , Senthil Rethesh 
Published: February 2025

Background:
Hepatitis C Virus (HCV) and Hepatitis B Virus (HBV) can cause acute and chronic viral infections. Due to their higher costs, potential side effects and drug interactions, and associated risks, some patients with HCV and HBV infections may not be able to afford conventional antiviral medications.

Objective:
The goal of this review paper is to highlight the advantages of Nigella sativa, or black seeds, in the treatment of patients with HCV and HBV infections.

Methods:
Medline/Pubmed/PMC, Scopus, Web of Science, Google Scholar, Science Di-rect, Ebsco, Embase, and reference lists were searched to locate the research studies that assessed the effects of different black seed (N. sativa) preparations on the telltale signs and symptoms of HCV and HBV infections.

Results:
Numerous preclinical and clinical investigations have suggested that black seeds (N. sativa) may be effective against HCV and HBV infections. Furthermore, N. sativa, or black seeds, have demonstrated a range of pleiotropic effects, such as antiviral activity against multiple other viruses and anti-inflammatory, antioxidant, and immunomodulatory properties that can lessen the symptoms and indicators of HCV and HBV infections.

Conclusion:
Patients with HCV and HBV infections may benefit from using black seeds (N. sativa) as an adjuvant therapy in addition to conventional therapy. Additional random-ized controlled clinical trials would confirm the safety and effectiveness of Nigella sativa (black seeds) in treating HCV and HBV infections.
Comorbidity of ADHD, but not Tics, has Detrimental Impact in Adults with OCD
Authors: Tan Oguz 
Published: February 2025

Background:
Obsessive-compulsive disorder (OCD) frequently cooccurs
with tic disorders (TD) and attention deficit and hyperactivity disorder
(ADHD). Data on adults are limited because most studies focus on children.

Objective:
We aimed to investigate the clinical and sociodemographic impact on
adults of the comorbidity of OCD with ADHD or TD.

Method:
We screened 356 adults seeking treatment for OCD in a cross-sectional
observational study for past or present ADHD and TD. We used the Yale-
Brown Obsessive-Compulsive Scale (Y-BOCS), Hamilton Depression Rating
Scale-17 Item (HDRS-17) and Beck Anxiety Inventory (BAI). We also questioned
parameters mainly involving adult life, such as marital status, unemployment
rate, educational attainment, suicide attempts (SA), hospitalization, alcohol
use disorder (AUD), substance use disorder (SUD) and smoking.

Results:
Of 356 adults, 71.07% had OCD only, 15.45% OCD+ADHD, 8.15%
OCD+TD and 5.34% OCD+ADHD+TD. Y-BOCS scores did not differ among
these categories. The comorbidity of ADHD was generally characterized by
higher HDRS-17 and BAI scores, higher prevalence of AUD/SUD, fewer years
of education and a higher percentage of non-married, divorced, and unemployed
individuals. SA and rates of hospitalization were similar across the four categories.
TD had no relationship with any of these characteristics.

Conclusion:
In adults with OCD, past or present ADHD has deleterious effects
on anxiety, depressive symptoms, educational attainment, employment and marital
status, whereas TD is not associated with any worsening of clinical or sociodemographic
characteristics.

conclusion:
In adults with OCD, past or present ADHD has deleterious effects on anxiety, depressive symptoms, educational attainment, employment and marital status whereas TD is not associated with any worsening of clinical or sociodemographic characteristics.
Pengaruh Leverage, Board of Directors, Dan Operating Capacity Terhadap Financial Distress Di Masa Pandemi Covid-19
Authors: Bani Amira Yusyah , Hariadi Bambang 
Published: February 2025

The pandemic has changed the world, including Indonesia that suffers from economic contraction through the government new policies in coping to reduce the pandemic outbreak. As such, this study aims to determine the effect of leverage, board of directors and operating capacity on financial distress during the covid-19 pandemic. The samples include 30 transportation and logistics companies listed on the Indonesia Stock Exchange for the period of 2020-2022, and the data are analyzed by structural equation modeling (SEM) utilizing the partial least square (PLS). This study finds that leverage and board of directors are able to affect the potential for financial distress in a company. However, operating capacity in this study has no effect on the potential for financial distress in a company. This study supports agency theory, and applies earnings per share in measuring financial distress proxies.

Abstrak
Pandemi mampu mengubah dunia. Dengan adanya pandemi, pemerintah telah mengeluarkan berbagai kebijakan baru sebagai upaya dalam menaggulangi dan mengurangi wabah pandemi. Imbas dari kebijakan tersebut hal ini memberikan kontraksi pertumbuhan terhadap ekonomi Indonesia. Penelitian ini bertujuan untuk mengetahu pengaruh leverage, board of directors dan operating capacity terhadap financial distress di masa pandemi covid-19. Penelitian ini menggunakan structural equation modelling (SEM) dengan mengunakan jenis partial least square (PLS). Adapun sampel penelitian adalah 30 perusahaan sektor transportasi dan logistik di Bursa Efek Indonesia periode 2020-2022. Penelitian ini menemukan bahwa leverage dan board of directors mampu mempengaruhi potensi terjadinya financial distress pada suatu perusahaan. Namun, operating capacity dalam penelitian ini tidak berdampak atau tidak berpengaruh pada potensi munculnya financial distress pada suatu perusahaan. Penelitian ini mendukung teori keagenan. Penelitian ini menggunakan earning per share pada pengukuran proksi financial distress.
Reaksi Pasar Modal Indonesia Terhadap Perdagangan Perdana Bursa Karbon Indonesia
Authors: Najubah Zian , Djazuli Atim 
Published: February 2025

The objective of this research is to assess and analyze the reaction of the capital market to the initial trading of carbon exchange, which is measured using abnormal return, cumulative abnormal return, dan trading volume activity, before and after the event. This event study assesses the impact of an event on stock prices. The research period is fifteen working days, i.e. seven days before, one day during, and seven days after the initial carbon trading. Using purposive sampling, six companies consisting of forestry industry, paper, and renewable energy firms listed on the Indonesia Stock Exchange were selected as the sample. The incorporated methods are Wilcoxon signed-rank test and paired sample t-test before and after the event. This study finds that the average abnormal returns before and after the initial carbon trading are not different, that the cumulative average abnormal returns before and after the event are different, and that the average trading volumes before and after the carbon trading are not different.

Abstrak
Penelitian ini memiliki tujuan untuk menguji dan menganalisis reaksi pasar modal terhadap perdagangan perdana bursa karbon yang diukur melalui variabel indikator abnormal return, cumulative abnormal return, dan trading volume activity pada sebelum dan sesudah peristiwa. Jenis penelitian yang digunakan adalah studi peristiwa untuk menilai dampak dari suatu peristiwa terhadap harga saham. Periode penelitian yang digunakan adalah 15 hari kerja Bursa Efek Indonesia yang terdiri dari 7 hari sebelum, 1 hari event date, dan 7 hari sesudah perdagangan perdana bursa karbon. Penelitian ini menggunakan teknik purposive sampling sehingga didapatkan 6 sampel perusahaan industri perhutanan, kertas, dan energi terbarukan yang terdaftar di Bursa Efek Indonesia. Metode penelitian yang digunakan adalah uji beda wilcoxon signed rank test dan paired sample t-test pada sebelum dan sesudah peristiwa. Hasil dari penelitian ini adalah variabel average abnormal return pada sebelum dan sesudah perdagangan perdana bursa karbon tidak memiliki perbedaan. Sedangkan, variabel cumulative average abnormal return pada sebelum dan sesudah perdagangan perdana bursa karbon memiliki perbedaan. Kemudian, variabel average trading volume activity tidak memiliki perbedaan pada sebelum dan sesudah perdagangan perdana bursa karbon.
Perilaku Herding Pada Harga Saham Sektor Energi
Authors: Rasiv Achmad Wildan , Juwita Himmiyatul Amanah Jiwa 
Published: February 2025

The need of human to make investments has encouraged them to invest in capital markets through, one of which, stocks. One of the stock sectors in the Indonesia Stock Exchange that has a good performance is energy. The classical financial theory assumes that investors should behave rationally in making decisions. However, this does not necessarily the case since there are chances for the occurrence of market anomaly due to herding behavior, which explains the inefficiency of markets. The objective of this research is to detect herding behavior in the prices of stocks in energy sector during the 2019-2022 period in all market conditions, in favorable market condition, and in unfavorable market condition. The herding behavior in this quantitative study was detected using the Cross-Sectional Absolute Deviation (CSAD) method, in which the non-linear relationship between return and CSAD was observed. The samples are 34 energy sector companies, selected via purposive sampling. The study incorporates secondary data of monthly closing prices of both the stocks and the Indonesia’s Composite Index. The results of the data analysis and hypothesis testing in EViews 12 indicate that herding behaviors were detected in the prices of stocks in the energy sector in the Indonesia Stock Exchange during the 2019-2022 period in all market conditions and in unfavorable market condition. This study also finds that there is no herding behavior in the unfavorable market condition during the 2019-2022 period.

Abstrak
Kebutuhan manusia untuk berinvestasi mendorong adanya investasi pada pasar modal, salah satunya adalah saham. Di Bursa Efek Indonesia, salah satu sektor saham yang memiliki performa baik adalah sektor energi. Teori keuangan klasik menyatakan bahwa investor seharusnya bertindak rasional dalam melakukan pengambilan keputusan investasi. Namun, hal ini tidak selalu terjadi dan terdapat peluang adanya anomali pasar yang disebabkan oleh perilaku herding yang menjelaskan bahwa pasar tidak senantiasa efisien. Penelitian ini bertujuan untuk mendeteksi perilaku herding pada harga saham sektor industri selama periode 2019-2022 pada keseluruhan kondisi pasar, kondisi pasar naik, dan kondisi pasar turun. Penelitian ini menggunakan pendekatan kuantitatif. Metode yang digunakan dalam mendeteksi herding adalah Cross Sectional Absolute Deviation (CSAD) dengan melihat hubungan non-linear return pasar dan CSAD. Sampel yang digunakan adalah 34 perusahaan sektor energi dengan teknik purposive sampling. Data yang digunakan adalah data sekunder harga penutupan bulanan saham tersebut dan IHSG pada periode 2019-2022. Analisis data dilakukan dengan pengujian hipotesis dengan perangkat lunak Eviews 12. Hasil penelitian ini menunjukkan bahwa terdapat perilaku herding pada harga saham sektor energi di Bursa Efek Indonesia periode 2019-2022 pada keseluruhan kondisi pasar dan kondisi pasar turun. Namun, tidak ditemukan perilaku herding pada kondisi pasar naik selama periode 2019-2022.