bluuebunny/crossref_metadata_2025_split huggingface dataset:
MRI-targeted biopsy cores from prostate index lesions: assessment and prediction of the number needed
Authors: Beetz Nick Lasse , Dräger Franziska , Hamm Charlie Alexander , Shnayien Seyd , Rudolph Madhuri Monique , Froböse Konrad , Elezkurtaj Sefer , Haas Matthias , Asbach Patrick , Hamm Bernd , Mahjoub Samy , Konietschke Frank , Wechsung Maximilian , Balzer Felix , Cash Hannes , Hofbauer Sebastian , Penzkofer Tobias 
Published: October 2022

Abstract
Background
Magnetic resonance imaging (MRI) is used to detect the prostate index lesion before targeted biopsy. However, the number of biopsy cores that should be obtained from the index lesion is unclear. The aim of this study is to analyze how many MRI-targeted biopsy cores are needed to establish the most relevant histopathologic diagnosis of the index lesion and to build a prediction model.

Methods
We retrospectively included 451 patients who underwent 10-core systematic prostate biopsy and MRI-targeted biopsy with sampling of at least three cores from the index lesion. A total of 1587 biopsy cores were analyzed. The core sampling sequence was recorded, and the first biopsy core detecting the most relevant histopathologic diagnosis was identified. In a subgroup of 261 patients in whom exactly three MRI-targeted biopsy cores were obtained from the index lesion, we generated a prediction model. A nonparametric Bayes classifier was trained using the PI-RADS score, prostate-specific antigen (PSA) density, lesion size, zone, and location as covariates.

Results
The most relevant histopathologic diagnosis of the index lesion was detected by the first biopsy core in 331 cases (73%), by the second in 66 cases (15%), and by the third in 39 cases (9%), by the fourth in 13 cases (3%), and by the fifth in two cases (<1%). The Bayes classifier correctly predicted which biopsy core yielded the most relevant histopathologic diagnosis in 79% of the subjects. PI-RADS score, PSA density, lesion size, zone, and location did not independently influence the prediction model.

Conclusion
The most relevant histopathologic diagnosis of the index lesion was made on the basis of three MRI-targeted biopsy cores in 97% of patients. Our classifier can help in predicting the first MRI-targeted biopsy core revealing the most relevant histopathologic diagnosis; however, at least three MRI-targeted biopsy cores should be obtained regardless of the preinterventionally assessed covariates.
Sirtuin 4 activates autophagy and inhibits tumorigenesis by upregulating the p53 signaling pathway
Authors: Li Juan , Zhan Hanxiang , Ren Yidan , Feng Maoxiao , Wang Qin , Jiao Qinlian , Wang Yuli , Liu Xiaoyan , Zhang Shujun , Du Lutao , Wang Yunshan , Wang Chuanxin 
Published: October 2022

AbstractThe role of autophagy in cancer is context-dependent. In the present study, we aimed to investigate the regulator and underlying mechanism of autophagy. We found that a sirtuin (SIRT) family member, SIRT4, was significantly associated autophagy pathway in pancreatic ductal adenocarcinoma (PDAC). Specifically, in vitro cell culture experiments and in vivo transgenic and xenografted animal models revealed that SIRT4 could inhibit tumor growth and promote autophagy in PDAC. In terms of the mechanism, we demonstrated that SIRT4 activated the phosphorylation of p53 protein by suppressing glutamine metabolism, which was crucial in SIRT4-induced autophagy. AMPKα was implicated in the regulation of autophagy and phosphorylation of p53 mediated by SIRT4, contributing to the suppression of pancreatic tumorigenesis. Notably, the clinical significance of the SIRT4/AMPKα/p53/autophagy axis was demonstrated in human PDAC specimens. Collectively, these findings suggested that SIRT4-induced autophagy further inhibited tumorigenesis and progression of PDAC, highlighting the potential of SIRT4 as a therapeutic target for cancer.
High-content, arrayed compound screens with rhinovirus, influenza A virus and herpes simplex virus infections
Authors: Olszewski Dominik , Georgi Fanny , Murer Luca , Andriasyan Vardan , Kuttler Fabien , Petkidis Anthony , Witte Robert , Yakimovich Artur , Fischer Lucy , Rozanova Alina , Yamauchi Yohei , Turcatti Gerardo , Greber Urs F. 
Published: October 2022

AbstractViruses are genetically and structurally diverse, and outnumber cells by orders of magnitude. They can cause acute and chronic infections, suppress, or exacerbate immunity, or dysregulate survival and growth of cells. To identify chemical agents with pro- or antiviral effects we conducted arrayed high-content image-based multi-cycle infection screens of 1,280 mainly FDA-approved compounds with three human viruses, rhinovirus (RV), influenza A virus (IAV), and herpes simplex virus (HSV) differing in genome organization, composition, presence of an envelope, and tropism. Based on Z’-factors assessing screening quality and Z-scores ranking individual compounds, we identified potent inhibitors and enhancers of infection: the RNA mutagen 5-Azacytidine against RV-A16; the broad-spectrum antimycotic drug Clotrimazole inhibiting IAV-WSN; the chemotherapeutic agent Raltitrexed blocking HSV-1; and Clobetasol enhancing HSV-1. Remarkably, the topical antiseptic compound Aminacrine, which is clinically used against bacterial and fungal agents, inhibited all three viruses. Our data underscore the versatility and potency of image-based, full cycle virus propagation assays in cell-based screenings for antiviral agents.
Validation of reference genes for gene expression analysis in fruit development of Vaccinium bracteatum Thunb. using quantitative real-time PCR
Authors: He Feng , Gui Liangxian , Zhang Yan , Zhu Bo , Zhang Xiaoping , Shen Min , Wan Fengying , Yang Lu , Xiao Jiaxin 
Published: October 2022

AbstractVaccinium bracteatum Thunb. (VBT) is widely distributed in the mountainous areas in eastern and southern China. VBT leaves have great medical value and can be used to stain rice to produce “Wumifan”. Its fruits also contain rich nutrients. However, there has been limited attention to exploring the molecular content of VBT. Previously, we performed RNA-seq on three typical VBT fruits that were at various stages of ripening, although a reliable reference gene was lost in validation.In this study, we selected ten candidate reference genes based on previous studies and transcriptomics analyses. Subsequently, these genes were evaluated using a combination of methods, including geNorm, NormFinder, and Bestkeeper, with a comprehensive ranking assessment. As a result, we found that the actin2, NADH, and ADK genes have high reliability for analysing the expression levels of genes involved in fruit development. Furthermore, the transcript levels of 15 DEGs from transcriptomic analysis were assessed using NADH as a reference gene, and RT-qPCR data were highly consistent with the transcriptomic data. These results provide reliable reference genes for further studying gene expression, which will be beneficial for comprehensively exploring VBT.
Studying the influence of external moment and force on a disc’s motion
Authors: Amer T. S. , Amer W. S. , El-Kafly H. 
Published: October 2022

AbstractIn this work, the influence of a gyrostatic moment vector (GMV) and the Newtonian field (NF) on the rotatory motion of a restricted rigid body (RB) according to disc case around a fixed point is examined. The basic equation of the body motion is used to get the regulating motion’s system as well as the three available independent first integrals. The system’s six equations and these integrals were reduced to two equations of a quasi-linear two-degrees-of-freedom autonomous system and one first integral. The disc has been presumed to be quickly rotating around one of the ellipsoid of inertia's main axis. Poincaré’s method of small parameter (PMSP) is applied to acquire the periodic solutions of the controlling system of the body’s motion. Euler's angles are utilized to characterize the body’s configuration at any instant in which it is graphed, as well as the obtained solutions to explore the good action of the body’s parameters on its motion. The phase plane graphs of these solutions are presented to examine their stabilities. The relevance of this work may be traced to its wide range of applications in fields as diverse as physics, engineering, and life sciences, including assembly and machine design.
Inter-annual variability patterns of reef cryptobiota in the central Red Sea across a shelf gradient
Authors: Villalobos R. , Aylagas E. , Pearman J. K. , Curdia J. , Lozano-Cortés D. , Coker D. J. , Jones B. , Berumen M. L. , Carvalho S. 
Published: October 2022

AbstractThe combination of molecular tools, standard surveying techniques, and long-term monitoring programs are relevant to understanding environmental and ecological changes in coral reef communities. Here we studied temporal variability in cryptobenthic coral reef communities across the continental shelf in the central Red Sea spanning 6 years (three sampling periods: 2013–2019) and including the 2015 mass bleaching event. We used a combination of molecular tools (barcoding and metabarcoding) to assess communities on Autonomous Reef Monitoring Structures (ARMS) as a standardized sampling approach. Community composition associated with ARMS for both methodologies (barcoding and metabarcoding) was statistically different across reefs (shelf position) and time periods. The partition of beta diversity showed a higher turnover and lower nestedness between pre-bleaching and post-bleaching samples than between the two post-bleaching periods, revealing a community shift from the bleaching event. However, a slight return to the pre-bleaching community composition was observed in 2019 suggesting a recovery trajectory. Given the predictions of decreasing time between bleaching events, it is concerning that cryptobenthic communities may not fully recover and communities with new characteristics will emerge. We observed a high turnover among reefs for all time periods, implying a homogenization of the cryptobiome did not occur across the cross shelf following the 2015 bleaching event. It is possible that dispersal limitations and the distinct environmental and benthic structures present across the shelf maintained the heterogeneity in communities among reefs. This study has to the best of our knowledge presented for the first time a temporal aspect into the analysis of ARMS cryptobenthic coral reef communities and encompasses a bleaching event. We show that these structures can detect cryptic changes associated with reef degradation and provides support for these being used as long-term monitoring tools.
Individual characteristics of adolescent psychiatric patients accessing psychotherapy in China
Authors: Ma Jinping , Zhou Hai , Li Xinwei , Fu Qinqin , Lu Guohua 
Published: October 2022

AbstractMost mental health problems develop during childhood and adolescence, so identifying the mental health needs and care pathways of adolescents is crucial to improving prevention. This study aimed to understand the characteristics of adolescent patients with mental disorders receiving psychotherapy in China. Data were collected retrospectively from the psychotherapy records of 116 patients at the Weifang Mental Health Centre. Information collected included demographics, stressors, duration of psychotherapy, and clinical diagnosis. Chi-square tests and negative binomial regression models were used to explore the relationship between demographic and clinical variables. The results showed that depression was the most common diagnosis, followed by anxiety and stress-related disorders and bipolar and related disorders. Rural patients were more likely to report family stress, while urban patients were more likely to report school stress. Female patients were more likely to report family stress and to be diagnosed with depression. Family stress, social stress, school stress, patient origin and economic conditions were all significant predictors of the duration of psychological treatment. This study helps to understand the characteristics and psychotherapeutic needs of adolescents with mental disorders who receive psychotherapy in China so that the positive role of psychotherapy in the prevention, treatment and rehabilitation of mental disorders can be better utilised.
Plasmin Inhibitor in Health and Diabetes: Role of the Protein as a Therapeutic Target
Authors: Alsayejh Basmah , Kietsiriroje Noppadol , Almutairi Mansour , Simmons Katie , Pechlivani Nikoletta , Ponnambalam Sreenivasan , Ajjan Ramzi A. 
Published: October 2022

The vascular obstructive thrombus is composed of a mesh of fibrin fibers with blood cells trapped in these networks. Enhanced fibrin clot formation and/or suppression of fibrinolysis are associated with an increased risk of vascular occlusive events. Inhibitors of coagulation factors and activators of plasminogen have been clinically used to limit fibrin network formation and enhance lysis. While these agents are effective at reducing vascular occlusion, they carry a significant risk of bleeding complications. Fibrin clot lysis, essential for normal hemostasis, is controlled by several factors including the incorporation of antifibrinolytic proteins into the clot. Plasmin inhibitor (PI), a key antifibrinolytic protein, is cross-linked into fibrin networks with higher concentrations of PI documented in fibrin clots and plasma from high vascular risk individuals. This review is focused on exploring PI as a target for the prevention and treatment of vascular occlusive disease. We first discuss the relationship between the PI structure and antifibrinolytic activity, followed by describing the function of the protein in normal physiology and its role in pathological vascular thrombosis. Subsequently, we describe in detail the potential use of PI as a therapeutic target, including the array of methods employed for the modulation of protein activity. Effective and safe inhibition of PI may prove to be an alternative and specific way to reduce vascular thrombotic events while keeping bleeding risk to a minimum.
Key Points
Does Timing of Resection Influence the Presence of Inflammation within Congenital Lung Malformations?
Authors: Engall Nick , Sethuraman Chitra , Wilkinson David John , Lansdale Nick , Peters Robert Thomas 
Published: October 2022

Abstract
Introduction Opinion remains divided on whether to resect an asymptomatic congenital lung malformation (CLM) and on optimal timing of resection. This study aimed to determine if age at resection of CLM correlates with the presence of histological inflammation and/or incidence of prior antibiotic administration for lower respiratory tract infection (LRTI).
Materials and Methods A retrospective review of all CLMs resected between 2009 and 2021 was carried out. Data on antenatal detection, incidence of preoperative antibiotic use for LRTI, operative details, and histological reports were analyzed. Fisher's exact test and logistic regression were used to look for correlation between age at resection and (1) histological inflammation and/or (2) preoperative LRTI.
Results A total of 102 patients underwent resection at age 14 months (interquartile range: 6–23). Eighty percent of children were asymptomatic in the neonatal period and 22% of these went on to develop a respiratory symptom. In total, 59% of specimens had histological evidence of inflammation, with a significantly higher rate of inflammation after 10 months of age (71 vs. 35%; p = 0.0012). Logistic regression showed there was a positive correlation between age at resection and treatment for previous LRTI (p = 0.020).
Conclusion Detection rates of inflammation in specimens resected after 10 months of age are double the rates of those resected prior to 10 months. Delaying resection of CLMs showed a higher frequency of treatment of LRTI. Earlier resection may therefore be advantageous for centers pursuing a resection strategy for asymptomatic lesions.
Single-Stage Continent Reconstruction of Composite Pericommissural Defects Using a Combination of Pacman-Style Free Radial Forearm Flaps and Modified Elastic Musculomucosal Flaps
Authors: Balakrishnan T.M. , Aruna M. , Christabel Prethee Martina , Jaganmohan J. 
Published: October 2022

Abstract
Introduction Based on the cross-innervation of buccal and marginal mandibular branches of the facial nerve, oblique elastic musculomucosal flaps (OEMMFs) can be harvested and used for continent neo-commissure and modiolus reconstructions. The composite pericommissural defects can then be reconstructed with double cutaneous paddles in Pacman-style free radial forearm flap (PFRFF). This novel single-stage continent reconstruction of composite post-excisional commissure and pericommissural (CPECPC) defects is evaluated in this study.
Patients and Methods This retrospective cohort study was conducted from April 2016 to March 2019. Forty-two patients underwent this type of reconstruction using a combination of PFRFF and OEMMF for the CPECPC defects. They were followed for an average period of 11.5 months. At the end of the follow-up period, they were assessed using the objective institutional scoring system by two independent observers and final score was computed for each patient.
Results The average score obtained at the end of the follow-up period was 11.5 (p = 0.035) using the institutional assessment scoring system, which evaluated both the overall aesthesis and function of the neo-commissure and modiolus.
Conclusions The combination of OEMMF and PFRRF for the single-stage reconstruction of CPECPC defects is a useful addendum for re-establishing the aesthesis and continence at the reconstructed site.
Three-quark potential at finite temperature and chemical potential*
Authors: Jiang Jia-Jie , Xiao Ya-Zhao , Qin Jiajia , Li Xiaohua , Chen Xun 
Published: October 2022

Abstract
Using gauge/gravity duality, we study the potential energy and the melting of triply heavy baryon at finite temperature and chemical potential in this paper. First, we calculate the three-quark potential and compare the results with quark-antiquark potential. With the increase of temperature and chemical potential, the potential energy will decrease at large distances. It is found that the three-quark potential will have an endpoint at high temperature and/or large chemical potential, which means triply heavy baryons will melt at enough high temperature and/or large chemical potential. We also discuss screening distance which can be extracted from the three-quark potential. At last, we draw the melting diagram of triply heavy baryons in the

plane.
Smuon in the NMSSM confronted with the muon g–2 anomaly and SUSY searches*
Authors: Wang Kun , Zhu Jingya 
Published: October 2022

Abstract
Motivated by recent supersymmetry (SUSY) search results, which prefer most SUSY particles to be heavy, and the muon g–2 anomaly, which prefers colorless SUSY particles to be light, we explore the status of a light smuon (the SUSY partner of a left-handed muon lepton) in the next-to-minimal supersymmetric standard model (NMSSM). Assuming colored SUSY particles to be heavy, and considering numerous experimental constraints, including muon g-2, SUSY searches, and dark matter, we scan the parameter space in the NMSSM with

-symmetry and check the status of colorless SUSY particles and their possible mass order, paying special attention to the smuon. After calculations and discussions, we find that the surviving samples can be divided into several scenarios, where the mass region and decay information of the smuon are given. Overall, the smuon mass can be approximately 0.1~1.8 TeV. These results may be useful for smuon searches at the LHC and future colliders.
Search for Majoron at the COMET experiment*
Authors: Xing Tianyu , Wu Chen , Miao Han , Li Haibo , Li Weiguo , Yuan Ye , Zhang Yao 
Published: October 2022

Abstract
A new Goldstone particle named Majoron is introduced in order to explain the origin of neutrino mass via some new physics models assuming that neutrinos are Majorana particles. By expanding the signal region and using likelihood analysis, it becomes possible to search for Majoron using experiments originally designed to search for

conversion. For the COMET experiment, the sensitivity of process

is able to reach

in Phase-I and

in Phase-II. Meanwhile, the sensitivities to search for Majoron in future experiments are also discussed in this article.
Dynamic performance of linear electromagnetic actuators in a stray magnetic field: theoretical analysis and experimental verification
Authors: WANG Rumeng , YANG Yong , WANG Shaoyu , ZHANG Ming 
Published: October 2022

Abstract
Linear electromagnetic actuators (LEAs) are widely used in tokamaks, but they are extremely sensitive to and are prone to fail in a high-strength stray magnetic field (SMF), which is usually a concomitant with tokamaks. In this paper, a multi-physics coupling analysis model of LEA, including magnetic field, electric circuit and mechanical motion, is proposed, and the dynamic characteristics of LEAs in SMFs are studied in detail based on the proposed model. The failure mechanism of LEAs in SMFs is revealed, and the influence of SMFs on the dynamic performance of LEAs is studied and quantified. It is shown that the failure threshold of the LEA selected in this work under the rated condition is 27 mT and 14 mT in the positive and negative direction, respectively. Under a typical SMF of 10 mT in the negative direction, the closing time of the LEA will be extended by 40%, while its opening time will be shortened by about 10%. Experimental tests are also conducted, which verify the validity of the proposed model and the analysis results. This paper provides a basis for the diamagnetic optimization design of LEA, and it is of great significance to ensure the reliable operation of the tokamak.
Efficient continual learning at the edge with progressive segmented training
Authors: Du Xiaocong , Venkataramanaiah Shreyas Kolala , Li Zheng , Suh Han-Sok , Yin Shihui , Krishnan Gokul , Liu Frank , Seo Jae-sun , Cao Yu 
Published: October 2022

Abstract
There is an increasing need for continual learning in dynamic systems at the edge, such as self-driving vehicles, surveillance drones, and robotic systems. Such a system requires learning from the data stream, training the model to preserve previous information and adapt to a new task, and generating a single-headed vector for future inference, within a limited power budget. Different from previous continual learning algorithms with dynamic structures, this work focuses on a single network and model segmentation to mitigate catastrophic forgetting problem. Leveraging the redundant capacity of a single network, model parameters for each task are separated into two groups: one important group which is frozen to preserve current knowledge, and a secondary group to be saved (not pruned) for future learning. A fixed-size memory containing a small amount of previously seen data is further adopted to assist the training. Without additional regularization, the simple yet effective approach of progressive segmented training (PST) successfully incorporates multiple tasks and achieves state-of-the-art accuracy in the single-head evaluation on the CIFAR-10 and CIFAR-100 datasets. Moreover, the segmented training significantly improves computation efficiency in continual learning and thus, enabling efficient continual learning at the edge. On Intel Stratix-10 MX FPGA, we further demonstrate the efficiency of PST with representative CNNs trained on CIFAR-10.