bluuebunny/crossref_metadata_2025_split huggingface dataset:
A structure function analysis of VST-COSMOS AGN
Authors: De Cicco D. , Bauer F. E. , Paolillo M. , Sánchez-Sáez P. , Brandt W. N. , Vagnetti F. , Pignata G. , Radovich M. , Vaccari M. 
Published: June 2022

Context. We present our sixth work in a series dedicated to variability studies of active galactic nuclei (AGN), based on the survey of the COSMOS field by the VLT Survey Telescope (VST). Its 54 r-band visits over 3.3 yr and single-visit depth of 24.6 r-band mag make this dataset a valuable scaled-down version that can help forecast the performance of the Rubin Observatory Legacy Survey of Space and Time (LSST).
Aims. This work is centered on the analysis of the structure function (SF) of VST-COSMOS AGN, investigating possible differences in its shape and slope related to how the AGN were selected, and explores possible connections between the AGN ensemble variability and the black-hole mass, accretion rate, bolometric luminosity, redshift, and obscuration of the source. Given its features, our dataset opens up the exploration of samples ∼2 mag fainter than most literature to date.
Methods. We identified several samples of AGN – 677 in total – obtained through a variety of selection techniques partly overlapping. Our analysis compares the results for the various samples. We split each sample in two based on the median of the physical property of interest, and analyzed the differences in the SF shape and slope, and their possible causes.
Results. While the SF shape does not change with depth, it is highly affected by the type of AGN (unobscured or obscured) included in the sample. Where a linear region can be identified, we find that the variability amplitude is anticorrelated to the accretion rate and bolometric luminosity, consistent with previous literature on the topic, while no dependence on black-hole mass emerges from this study. With its longer baseline and denser and more regular sampling, the LSST will allow for an improved characterization of the SF and its dependencies on the mentioned physical properties over much larger AGN samples.
Alpha emitting nuclides in nuclear medicine theranostics
Authors: Miederer Matthias 
Published: June 2022

AbstractTheranostic applications with radio-isotopes currently are rapidly progressing and expand nuclear medicine application in clinical routine. Alpha emitting isotopes, in particular, have long been hypothesized to achieve relevant advances for the treatment of malignancies. Here, an overview of their properties and the knowledge of radiobiology is reviewed in view of clinical translation. Clinical evidence of radiopharmaceuticals based on alpha emitters is summarized with a focus on recent developments for treatment of metastasized castration resistant prostate cancer.
Evaluation of Intraoperative Frozen Section Analysis with Final Histopathology Results for Sentinel Lymph Node Biopsy: Z0011 Criteria Eligible Versus Ineligible Breast Cancer
Patients
Authors: Reinhardt Florian , Fiedler Anna , Borgmeier Felix , Reinecke Petra , Esposito Irene , Mattes-György Katalin , Dabir Mardjan , Friebe Verena , Krawczyk Natalia , Kaleta Thomas , Hoffmann Jürgen , Ruckhäberle Eugen , Fehm Tanja , Roth Katrin S. , Mohrmann Svjetlana 
Published: June 2022

Abstract
Background Intraoperative frozen section analysis (FSA) of sentinel lymph nodes (SLNs) declined in the post American College of Surgeons Oncology Group Z0011 (ACOSOG Z0011) trial
era. However, for those patients who do not meet the ACOSOG Z0011 criteria, FSA continues to be a valuable tool in intraoperative decision-making for axillary lymph node dissection (ALND).
The aim of this study was therefore to retrospectively evaluate the benefit and accuracy of FSA of Z0011 criteria eligible versus ineligible patients and identify possible predictive factors
for false negative results.
Methods Intraoperative FSA was performed on SLNs of 522 cT1–T3 breast cancer patients between 2008 and 2013. Clinicopathologic characteristics were retrospectively assessed by chart
review.
Results Overall FSA sensitivity and specificity was 67.8% and 100%. Sensitivity was generally higher for macrometastasis than for micrometastasis. The Z0011 eligible group showed a
sensitivity and specificity of 72.7% and 100% versus 62.1% and 100% in the Z0011 ineligible group. Importantly, subgroup analysis of ≤ 2 versus > 2 positive SLNs of the Z0011 eligible
group demonstrated both a 100% specificity and sensitivity. Several clinicopathologic factors were associated with a higher rate of false negative results in the Z0011 ineligible patient
group. FSA was beneficial for 22.2% of Z0011 ineligible patients and for only 0.6% of Z0011 eligible patients regarding intraoperative decision-making for ALND.
Conclusions FSA continues to be especially beneficial in the intraoperative assessment of SLNs in the Z0011 ineligible group to prevent second stage ALND. Despite an overall lower
FSA sensitivity in the Z0011 eligible patient group, FSA offers in both groups a comparable high sensitivity and diagnostic accuracy for macrometastasis.
Update Breast Cancer 2022 Part 2 – Advanced Stage Breast Cancer
Authors: Müller Volkmar , Welslau Manfred , Lüftner Diana , Schütz Florian , Stickeler Elmar , Fasching Peter A. , Janni Wolfgang , Thomssen Christoph , Witzel Isabell , Fehm Tanja N. , Belleville Erik , Bader Simon , Seitz Katharina , Untch Michael , Thill Marc , Tesch Hans , Ditsch Nina , Lux Michael P. , Aktas Bahriye , Banys-Paluchowski Maggie , Schneeweiss Andreas , Harbeck Nadia , Würstlein Rachel , Hartkopf Andreas D. , Kolberg Hans-Christian , Wöckel Achim 
Published: June 2022

AbstractFor patients with advanced breast cancer, several novel therapies have emerged in recent years, including CDK4/6 inhibitors, immune checkpoint inhibitors, PARP inhibitors, alpelisib,
tucatinib and trastuzumab-deruxtecan, and sacituzumab-govitecan, which have transformed and expanded the therapeutic landscape for patients with advanced breast cancer. Some of these
substances have now been approved for use in the early stages of the disease, or are expected to be approved in the near future, so the therapeutic landscape will change once again.
Therefore, current scientific efforts are focused on the introduction of new substances and understanding their mechanisms of progression and efficacy. This review summarizes recent
developments with reference to recent publications and conferences. Findings on the treatment of patients with HER2-positive breast cancer and brain metastases are presented, as are a number
of studies looking at biomarkers in patients with HER2-negative, hormone receptor-positive breast cancer. In particular, the introduction of oral selective estrogen receptor degraders
provides new opportunities to establish biomarker-based therapy. Molecular diagnostics is establishing itself as a diagnostic marker and parameter of progression.
Effect of Teriparatide on Subsequent Fracture and Bone Mineral Density in 47 Women with Pregnancy- and Lactation-associated Osteoporosis and Vertebral Fractures
Authors: Hadji Peyman , Mouzakiti Niki , Kyvernitakis Ioannis 
Published: June 2022

Abstract
Introduction Pregnancy- and lactation-associated osteoporosis (PLO) with predominantly vertebral fractures is a rare but severe disease which can occur in the last trimester of
pregnancy or postpartum. The aim of the present study was to assess the impact of teriparatide on subsequent fractures and bone mineral density (BMD) in patients with PLO.
Materials and Methods A total of 47 patients with PLO and postpartum spinal fractures (mean: 4 fractures) undergoing treatment with teriparatide were investigated. The data
collection period was set between 2006 and 2018. All patients received a subcutaneous injection of 20 µg teriparatide once a day for 24 months as well as individually adapted vitamin D
supplementation. After 24 months of treatment, all women received no further treatment and either had regular menstrual cycles or took oral contraceptives. Fractures were confirmed by X-ray
or MRI. Changes in BMD from baseline were examined using serial DXA measurements.
Results After 24 months of teriparatide treatment, we could demonstrate an increase in BMD at the lumbar spine, femoral neck and total hip of + 30.1%, + 11.7% and + 12.2%
respectively (p < 0.001 for all). At 12 months after cessation of treatment, BMD remained stable compared to the 24-month measurements at the lumbar spine, femoral neck and total hip
which showed non-significant changes of + 1.4%, + 2.6% and + 4.1% respectively. Out of the 47 patients with PLO with a mean of 4 existing fractures, 4 patients (7.8%) sustained a subsequent
fracture, two after 3 – 5 months of treatment and two at > 6 months of treatment.
Conclusion 24 months of treatment with teriparatide in women with PLO and multiple vertebral fractures significantly increased BMD, predominantly BMD of the spine. As patients were
premenopausal, there was no significant decrease in BMD in the following 12 months after cessation of treatment.
Gray Matter Brain Alterations in Type 1 Diabetes – Findings
Based on Detailed Phenotyping of Neuropathy Status
Authors: Croosu Suganthiya S. , Hansen Tine M. , Røikjer Johan , Mørch Carsten D. , Ejskjaer Niels , Frøkjær Jens B. 
Published: June 2022

Abstract
Aims This study investigated brain structure in patients of type 1
diabetes with diabetic peripheral neuropathy (DPN) and type 1 diabetes with
neuropathic pain and the associations to clinical, peripheral, and cognitive
measurements.
Methods Sixty individuals with type 1 diabetes and 20 healthy controls
were included in the study. Nineteen individuals with type 1 diabetes and
neuropathic pain, 19 with type 1 diabetes and DPN, 18 with type 1 diabetes
without DPN, and 20 healthy controls were included in the brain analyses. We
utilized structural brain magnetic resonance imaging to investigate total and
regional gray matter volume.
Results Significant lower gray matter volume was found in type 1 diabetes
with neuropathic pain and in type 1 diabetes without DPN compared to healthy
controls (p=0.024 and p=0.019, respectively).
Lower insula volume was observed in all three diabetes groups (all
p≤0.050). Thalamus and hippocampus volume was lower in type 1
diabetes with neuropathic pain, cerebellum volume was lower in type 1 diabetes
with DPN, and somatosensory cortex volume was lower in type 1 diabetes without
DPN (all p≤0.018). Attenuated memory was associated with lower
gray matter volume in type 1 diabetes with DPN. No associations were found
between gray matter volume and clinical/peripheral measurements.
Conclusion We demonstrated lower gray matter volume in individuals with
type 1 diabetes regardless of the presence of DPN and neuropathic pain. Hence,
central gray matter alteration was not associated with peripheral
alterations.
Relation between Selenium and Female Fertility: A Systematic Review
Authors: Lima Luiz Gustavo , Santos André Amaro Mamédio dos , Gueiber Tiago Daniel , Gomes Ricardo Zanetti , Martins Camila Marinelli , Chaikoski Andrielle Cristina 
Published: June 2022

Abstract
Objective To analyze the influence of selenium in female fertility.
Data source A search was performed in the following databases: MEDLINE, Web of Science, Scopus, SciELO, LILACS, MDPI, ScienceDirect, and Europe PMC. The descriptors selected were “selenium” AND “female” AND “fertility”. The search interval was from 1996 to 2021.
Study selection The evaluation was performed independently by two reviewers, and a third reviewer confirmed the inclusion of papers in case of divergence between the first two reviewers. Papers were selected after the title and abstract were read, and those that met the eligibility criteria had the full text read.
Data collection The following data was extracted: author, year of publication, country, type of study, objective, method, sample size, follow-up period, patients' mean age, inclusion and exclusion criteria, and concentration of serum and capillary selenium. The data was organized in chronological order of paper publication.
Data synthesis The number of papers identified totaled 3,800, out of which 7 were included in the systematic review. The studies indicated a positive correlation between serum selenium and antioxidant concentration in the follicular fluid, reduction in antithyroid antibodies, oocyte production and follicle number.
Conclusion Selenium supplementation is promising in women with this micronutrient deficiency to promote improvement of the reproductive efficiency and prevent damage to the pregnancy. Further studies on this theme are still required.
The Impact of a Multidisciplinary Opioid Use Disorder Prenatal Clinic on Breastfeeding Rates and Postpartum Care
Authors: Hensel Drew , Helou Nicole El , Zhang Fan , Stout Molly J. , Raghuraman Nandini , Friedman Hayley , Carter Ebony , Odibo Anthony O. , Kelly Jeannie C. 
Published: June 2022

Objective To evaluate the hypothesis that patients with opioid use disorder (OUD), who receive prenatal care in a multidisciplinary, prenatal OUD clinic, have comparable postpartum breastfeeding rates, prenatal and postpartum visit compliance, and postpartum contraceptive use when compared with matched controls without a diagnosis of OUD.
Study Design This was a retrospective, matched, cohort study that included all patients who received prenatal care in a multidisciplinary, prenatal OUD clinic—Clinic for Acceptance Recovery and Empowerment (CARE)—between September 2018 and August 2020. These patients were maintained on opioid agonist therapy (OAT) throughout their pregnancy. CARE patients were matched to controls without OUD in a 1:4 ratio for mode of delivery, race, gestational age ± 1 week, and delivery date ± 6 months. The primary outcome was rate of exclusive breastfeeding at maternal discharge. Secondary outcomes included adherence with prenatal care (≥4 prenatal visits), adherence with postpartum care (≥1 postpartum visit), postpartum contraception plan prior to delivery, and type of postpartum contraceptive use. Conditional multivariate logistic regression was used to account for possible confounders in adjusted calculations.
Results A total of 210 patients were included (42 CARE and 168 matched controls). Despite having lower rates of adequate prenatal care, 40 CARE patients (95%) were exclusively breastfeeding at discharge resulting in CARE patients being significantly more likely to be breastfeeding at discharge (adjusted relative risk (aRR): 1.28, 95% confidence interval [CI]: 1.05–1.55). CARE patients and controls demonstrated no difference in postpartum visit compliance (86 vs. 81%, aRR: 1.03, 95% CI: 0.76–1.40) or effective, long-term contraception use (48 vs. 48%; aRR: 0.81, 95% CI: 0.36–1.84).
Conclusion In the setting of multidisciplinary OUD prenatal care during pregnancy, patients with OUD were more likely to be breastfeeding at the time of discharge than matched controls, with no difference in postpartum visit compliance or effective, long-term contraception.
Key Points
Operation und Therapie bei Omarthrose
Authors: Beeler Silvan , Wieser Karl 
Published: June 2022

ZusammenfassungDer Begriff Arthrose bezeichnet eine degenerative Gelenkerkrankung, von der jedes Gelenk betroffen sein kann. Unter Omarthrose wird der Gelenkverschleiß des Glenohumeralgelenks verstanden. Der Beitrag bietet Ihnen ein Update zu Operationen und Physiotherapie nach Omarthrose-OP.
Decoupling VaR and regulatory capital: an examination of practitioners’ experience of market risk regulation
Authors: McCullagh Orla , Cummins Mark , Killian Sheila 
Published: June 2022

AbstractThe central role of Value-at-Risk (VaR) within bank market risk regulation received significant criticism from financial media and government investigations into the events of the 2007–2009 financial crisis. Impending reform of bank market risk regulation under the Fundamental Review of the Trading Book (FRTB) demotes VaR, replacing it with a layered framework centred on expected shortfall (ES). However, many of these criticisms assume full integration of internal and regulatory market risk models and further, a linear relationship between risk models and regulatory capital. We examine bank practitioners’ perspectives and experienced realities to better understand the operational relationship between internal and regulatory market risk models, and between risk models and capital. This has important policy implications for the efficacy of the reforms to banking regulation, financial stability and navigating the dichotomy of private and public interests.
Extinction coefficient measurement of supercritical water-based multi-walled carbon nanotube nanofluids
Authors: Choi Tae Jong , Kang Seo Yeon , Jang Seok Pil 
Published: June 2022

This study measured the extinction coefficients of supercritical water (SCW)-based multi-walled carbon nanotube (MWCNT) nanofluids by using an in-house developed chamber. A He–Ne laser with a wavelength of 632.8 nm was employed as the light source. Rod-shaped quartz with a diameter of 3 mm and a length of 305 mm was installed at the top and bottom of the chamber so that the laser could pass through the chamber. To maintain the SCW-based MWCNT nanofluids in the chamber, the chamber was designed to reach up to 400 °C and 30 MPa. Based on the experimental data, it is shown that the extinction coefficient of the SCW-based MWCNT nanofluids linearly increases within the range of the volume fraction from 0 to 0.02 vol. % and belongs to the independent scattering regime. Moreover, the enhancement of the extinction coefficient of the SCW-based MWCNT nanofluids shows promise as a working fluid for ultra-high temperature solar thermal systems, such as concentrated solar power plants.
Effect of barrier thickness on photoelectric properties of InGaN/GaN asymmetric multiple-quantum-well structure light-emitting diode
Authors: Cai Li-E. , Zhang Bao-Ping , Lin Hao-Xiang , Cheng Zai-Jun , Ren Peng-Peng , Chen Zhi-Chao , Huang Jin-Man , Cai Lin-Lin 
Published: June 2022

GaN/GaInN asymmetric multiple quantum well light-emitting diodes with varying potential barrier thicknesses (5 and 15 nm) are grown by using metal organic chemical vapor deposition. The narrow barrier structure improves the performance of the device, including the super-linear increase of electroluminescence integral intensity, the mitigation of efficiency droop at high current density, the reduction of wavelength drift, the reduction of forward voltage, and the improvement of wall-plug efficiency. This is due to the narrowing of the thickness of the quantum barrier, which results in the smaller electric field among the quantum well, the weakening of the quantum confinement Stark effect, the more uniform distribution of carriers across the active region of the device, and the suppression of electron leakage.
A feedforward inhibitory premotor circuit for auditory–vocal interactions in zebra finches
Authors: Norton Philipp , Benichov Jonathan I. , Pexirra Margarida , Schreiber Susanne , Vallentin Daniela 
Published: June 2022

SignificanceDuring conversations, we frequently alternate between listening and speaking. This involves withholding responses while the other person is vocalizing and rapidly initiating a reply once they stop. Similar exchanges also occur in other animals, such as songbirds, yet little is known about how brain areas responsible for vocal production are influenced by areas dedicated to listening. Here, we combined neural recordings and mathematical modeling of a sensorimotor circuit to show that input-dependent inhibition can both suppress vocal responses and regulate the onset latencies of vocalizations. Our resulting model provides a simple generalizable circuit mechanism by which inhibition precisely times vocal output and integrates auditory input within a premotor nucleus.
The neural signature of the decision value of future pain
Authors: Coll Michel-Pierre , Slimani Hocine , Woo Choong-Wan , Wager Tor D. , Rainville Pierre , Vachon-Presseau Étienne , Roy Mathieu 
Published: June 2022

Significance
We often willingly experience pain to reach a goal. However, potential pain can also prevent reckless action. How do we consider future pain when deciding on the best course of action? To date, the precise neural mechanisms underlying the valuation of future pain remain unknown. Using functional MRI, we derive a whole-brain signature of the value of future pain capable of predicting participants’ choices to accept pain in exchange for a reward. We show that this signature is characterized by a distributed pattern of activity with clear contributions from structures encoding reward and salience, notably the ventral and dorsal striatum. These findings highlight how the brain assigns value to future pain when choosing the best course of action.
When hands stop moving, interaction keeps going
Authors: Lepeut Alysson 
Published: June 2022

Abstract
This study explores moments in signed and spoken conversation when manual production is on hold and its resulting interactive ramifications. Typically, the temporal structure of gesture and sign can be decomposed into a stream of distinct manual phases. There are moments, however, when this activity is stopped. This may happen for various reasons, e.g., when seeking attention, holding the floor or during overlaps. Holds have mostly been examined in sign languages regarding prosody, syntax, and corresponding to vowel lengthening in spoken languages. In gesture studies, they have been overlooked for not deemed relevant in the gesture-speech interface. By combining contrastive and multimodal analyses, this paper examines the relevance of holds as potential meaning-making practices deployed by LSFB signers and its comparison to Belgian French speakers. In 3 hours of video-recorded material drawn from 3 multimodal corpora, the following question is addressed: what are the roles of holds in the management of interaction within and across languages/modalities? While most of linguistic work considers manual movements to express referential content, the observations here push to reconsider the common boundary set between what constitutes gestural/linguistic phenomena in one language and what does not.
Terminology and ontologies
Authors: Montiel-Ponsoda Elena 
Published: June 2022

Abstract
This chapter revisits the relation between terminologies and ontologies, focusing on those aspects that lie at the intersection of the two worlds. Terminological resources, methods and tools that follow the conceptual paradigm are analyzed to explain how close they are to ontologies. Then, current methodologies in Ontology Engineering are reviewed from a terminological perspective to highlight those aspects of terminological practice that are becoming increasingly relevant in an ontology development process. Finally, current trends and models in Ontology Engineering whose aim is to enrich ontologies with linguistic (terminological) descriptions are examined in the light of their use in Artificial Intelligence and Natural Language Processing tools, pointing to a renewed convergence of these two worlds.
Units of understanding in Sociocognitive Terminology studies
Authors: Temmerman Rita 
Published: June 2022

Abstract
In Sociocognitive Terminology theory the point of departure is the ‘unit of understanding’(UoU). A UoU exists because of three key elements. First, the understander relies on the senses to get a grip on aspects of reality. Second, the understander has a functioning mind. Third, the understander has proficiency in at least one human language allowing him to put into words his personal understanding of a unit as well as to understand discourse that represents earlier references to the UoU under consideration. Four more aspects need to be added to make this theory complete: prototypicality in understanding, embeddedness in society, a diachronic perspective, and the impact of metaphorical framing. Three case studies that were executed within the framework of Sociocognitive Terminology studies are presented.