bluuebunny/crossref_metadata_2025_split huggingface dataset:
Article Review: The Approach to Celiac Disease in Children
Authors: Mohammed Ali Mohannad Kadhim 
Published: October 2022

A persistent, global, immunological illness called CD affects those who are genetically predisposed to it. Inside the average population, celiac disease is thought to affect 1% of people worldwide. Its incidence varies according to regional or racial differences. Due to improved medical understanding with awareness, as well as the widespread use of extremely sensitive or precise diagnostic tests for celiac disease, the incidence of celiac disease had considerably grown over the last thirty years. Even though there is more understanding or awareness regarding celiac disease, up to 95% of celiac sufferers still go untreated. The uneven nature of small intestinal mucosa alterations may result in false-negative small intestinal histopathology. Throughout Western Europe, one percent of people suffer with CD.
The research of milder clinical traits or the use of serological testing has boosted the detection accuracy. Although the age of presentation varies, individuals often present during the fourth or sixth decades. Compared to juvenile instances, adult’s instances of CD are more prevalent, with individuals as old as 65 are now being identified or given diagnoses. It usually happens after adding gluten to the diet. There is a considerable change toward fewer patients presenting with mild dementia or as symptomatic adults identified during testing, however there is a tendency towards decreasing individuals who present with severe CD marked by diarrhoea.
Determinants of Household Waste Management in Alam Barajo District, Jambi City
Authors: Fitria Eka Putri  , Muhammad Agung Perdana  , Hubaybah  , Fajrina Hidayati  , Adelina Fitri  , Puspita Sari  
Published: October 2022

Waste that cannot be recycled and processed properly will be very dangerous for human health and the environment. Based on data from the Environmental Service of Jambi City, garbage in Jambi City reached a total of 465,693,805 kg/day, and the largest waste generation data was in Alam Barajo District where the waste generated was 75,409,004 kg/day. This research is an observational study that uses a quantitative approach with a cross sectional method. The population of Alam Barajo sub-district is 30,786 families. The sampling technique is a disproportionate stratified random sampling technique. Bivariate analysis using thetest Chi-Square, the relationship between the independent variable and the dependent variable, namely knowledge (p = 0.000), attitude (p = 0.122), support from community leaders (p = 0.607), support from health workers (p = 0.227) with waste management household. There is a relationship between knowledge and household waste management in Alam Barajo sub-district and there is no relationship between attitudes, support from community leaders, support from health workers and household waste management.
ANALYSIS OF FACTORS RELATED TO THE EVENT OF PRIMARY DYMENOROREA IN ADOLESCENT WOMEN IN SITINJAU LAUT DISTRICT
Authors: Puspita Sari  , Lia Nurdini  , Fefi Tri Yuzela  , Fitria Eka Putri  , Solihin Sayuti  
Published: October 2022

Primary dysmenorrhea is menstrual pain that is found without obvious abnormalities of the genital organs. Primary dysmenorrhea often occurs in adolescent girls aged 10-14 years (early adolescence). Primary dysmenorrhea refers to pain without obvious pathological pelvic disease or menstrual pain with normal pelvic anatomy, usually beginning in adolescence after their ovulatory cycle has established. The purpose of this study was to determine the relationship between age of menarche, duration of menstruation and exercise habits in adolescent girls in Sitinjau Laut District.
This research is a quantitative research with a cross sectional design. Data collection was carried out in March-April 2021. The research population was... Young Women with a research sample of 198 young women. Sampling was done by using proportional random sampling technique. This study consisted of the independent variable "age of menarche, duration of menstruation and exercise habits" and the dependent variable "primary dysmenorrhea". Data analysis using Chi-Square test.
The incidence of primary dysmenorrhea in adolescent girls is 74.2%. Factors related to the incidence of primary dysmenorrhea in adolescent girls were age at menarche (P=0.000; 1.870; 95% CI 1.371-2.552) and length of menstruation (P=0.001; 0.720; 95% CI 0.635-0.817). And there is no relationship between exercise habits (P=0.720; 1.184 95% CI 1.012-1.835).
There is a relationship between the age of menarche with the incidence of primary dysmenorrhea and the length of menstruation in adolescent girls in the District of Sitinjau Laut.
MULTIVARIATE ANALYSIS OF PERFORMANCE OF JAMBI CITY HEALTH SERVICE EMPLOYEES
Authors: Rumita Ena Sari  , Arnild Augina Mekarische  , Shafira Ainun Hafilda  
Published: October 2022

Background: Performance is a function of encouragement and expertise for a person in carrying out an obligation and work in order to have a certain degree of ability and ability. Jambi Health Department report in 2020 it was known that of the 12 types of health services in the Jambi City Health Office, there are 8 health service performances that have decreased. This research aims to analyzed the performance of employees at the Jambi City Health Office.

Methods: This type of research was a quantitative research with a cross sectional research design. Total population in this research were 140 respondents with a total sample of 82 respondents. Data collected was carried out in January 2022 to March 2022. Data collected used questionnaires that had been tested for validity and reliability. Data analyzed with SPSS with multiple linear regression test.

Results: Based on the results research, the final model found that employee performance = 1.709 - 0.062 age + 0,098 vision and mission + 0.355 measure of success + 0.121 satisfaction with insentive + 0.262 satisfaction with superiors + 0.109 satisfaction with colleagues. The most influential factor on employee performance was the measure of success where if you increase it 100% (1 point) then the performance will increase by 31.7%.

Conclusion: The most influential factor on employee performance was measure of success where if increased by 100% (1 point) then the performance will increase by 31.7%. It is hope that employees who are expected to use time effectively, know the results that each program wants, have supporting factors in achieving success, pay attention to employee incentives, superiors must be firm in giving warnings to employees who violate, and employees increase interaction with co-workers achieved.
Relationship of Age with the Event of Chronic Energy Lack For Pregnant Mothers
Authors: Ike Trinadewi Wahyuni  , Mariyani Mariyani  
Published: October 2022

Background : According to WHO, every day in 2019 around 810 women died, by the end of the year 295,000 people from 94% of them were in developing countries. The direct cause of maternal death by 90% are complications that occur during delivery and after delivery. Chronic Energy Deficiency is a condition caused by an imbalance in nutritional intake between energy and protein, so that the nutrients needed by the body are not fulfilled. Based on the results of the Nutrition Status Monitoring in 2017, it was found that the percentage of pregnant women with chronic energy deficiency in Indonesia was 14.8%. The prevalence of CED in pregnant women in Indonesia based on Riskesdas data in 2018 is 17.3% and based on the Indonesian Health profile that the incidence of CED in pregnant women in 2019 is 17.9%
Objective : Knowing the relationship between age and the incidence of chronic energy deficiency (KEK) in pregnant women
Methods : Analytical with cross sectional approach. The sample in this study were all maternity mothers registered in the register from March 2021 to May 2022 as many as 224 people (total sampling).
Results : The distribution of the frequency of CED incidence in pregnant women is 366.6%. Age of pregnant women mostly aged 20-35 years 69.2%, LBW 3.6% and 3.1% bleeding. There is a significant relationship between age and the incidence of CED in pregnant women with a p value of 0.000.
Conclusions and Suggestions: There is a significant relationship between age and the incidence of CED in pregnant women. It is expected that health workers, especially midwives, provide counseling to pregnant women about nutritional needs during pregnancy.
Gestión de ventas y su impacto en la rentabilidad del concesionario Metrocar.
Authors: Arteaga Roldan Jhon Joseph , Molina de Lozano Mara 
Published: October 2022

Las organizaciones requieren potenciar sus ventas para mantenerse en el mercado y contar con porcentajes de rentabilidad que le permitan ser competitivos; por tal razón, es importante analizar cómo se gestionan las ventas y la rentabilidad en una empresa con la finalidad de que agreguen valor a las metas empresariales. En este contexto, el objetivo es analizar la gestión de venta y su impacto en la rentabilidad del concesionario Metrocar. La investigación fue de tipo descriptivo con diseño no experimental transversal. Se utilizó un cuestionario diseñado en Google Forms aplicado a los ejecutivos de ventas de la empresa. Además, se utilizaron los estados financieros correspondientes a los años 2020 y 2021 obtenidos directamente del concesionario. Como principales resultados se obtuvo que, la empresa planifica las ventas realizando comparativos de cumplimiento, se establecen objetivos de ventas alcanzables cumpliendo con las proyecciones estimadas, así como también el nivel de competitividad de la empresa es considerado como satisfactorio. Por otro lado, la rentabilidad económica de la empresa y financiera muestran que los activos están produciendo rendimiento sobre la inversión, así como se han generado utilidad a favor del propietario, por otra parte, se determinó que la capacidad de convertir las ventas en utilidad no ha sido eficiente en Metrocar. Finalmente, se concluyó que la empresa mostró ventas crecientes cumpliendo con los objetivos establecidos, sin embargo, los gastos operativos fueron muy altos afectando a la rentabilidad neta, resultado de esto se declaró 0%.
A REVIEW ON POTENTIAL OF MEDICINAL PLANT: LIMONIA ACIDISSIMA L.
Authors: Bhavsar Smit , Sapra Palak , Maitreya Bharat , Mankad Archana 
Published: October 2022

Plant is an important source of medicine and plays a key role in achieving objectives of WHO for wellbeing of all mankind. People are getting aware about natural products, to fulfil the requirement of medicinal values, Limonia acidissima
L. of family Rutaceae, emerged out to be one of the most valuable plant owing multiple medicinal properties. The main objective of the present study is to recognize and identify different chemical constituents of the plant, which are important in the field of medicine. Hence in this article, the attempt has been made to study literature of different medicinal values, Pharmacological activities and the Ethnobotanical uses of Limonia acidissima L. The complied information of the plant can be used in various medicinal field.
FT-IR ANALYSIS OF THE CRUDE SAMPLE OF ACHYRANTHES ASPERA L. LEAVES
Authors: Qureshi Shirin , Solanki Hitesh 
Published: October 2022

Achyranthes aspera L. belonging to the family Amaranthaceae commonly known as ‘Aghedo’ is an important medicinal herb found as a weed throughout India. The whole plant is of immense importance because of a wide range of pharmacological actions. Hence, the present study was undertaken to identify the functional groups present within the leaves. The FT-IR results showed the presence of 11 peaks, which confirmed the presence of essential phytochemicals present in the crude sample of powdered A.aspera leaves.
IN SILICO SCREENING OF MAJOR CANCER DRUG TARGETS (GROWTH FACTOR RECEPTORS) FOR NATURE DERIVED PHYTOCHEMICALS
Authors: Trivedi Tithi , Kumar Siva , Mankad Archana , Patel Saumya , Rawal Rakesh , Pandya Himanshu 
Published: October 2022

Cancer i s a group of abn ormal cells. The unregulated gro wth factor recepto r t yrosin e kinase ( GFR- TK) proteins are implicated in the proliferation o f mo re than 60 % o f all can cer t ypes. Screenin g o f ph ytoch emicals for their anti - angiogenic potential has b een a gro wing area o f research in the mod ern d ecad e. There i s a well - kno wn principle that natural co mpounds are active against several diseases, includin g variou s t yp es of can cer. Th e present research work fo cuses on kno wn gro wth factor receptors ( GFRs) as an important target fo r co mputation al s tudies. In this stud y, 96 curated anti - can cer co mpounds were virtu ally screened against the EGFR, FGFR, IGFR, and HGFR usin g molecular dockin g so ftware. For each GFR, we h ave considered ten top most results as potential hits. Among them, co mmon f i ve results are: Spiro solan e, Ginkgetin, Fangchinoline, Theaflavin and Ursolic acid. These co mpounds have b een reported to show antican cer activities in the l i t erature. With the help of different interaction analysis tools, the protein - l i gand inter action patterns between th e functional groups o f these co mpounds were analyzed. Hydro gen bonding and h ydrophobic forces are th e main co mponents o f th e interactions o f th ese hits, similar to those exp erimental fo r th e kno wn inhibitors. Fro m the maximu m nu mb ers o f hits, i t could be indicated that co mpounds Spirosolan e, Ginkgetin, Fan gchinoline, Th eaflavin and Ursolic acid are pro miscuous l ead s in the drug disco very process.
Shahjahanpur Jile Ke gramin Vikas Mein Swrojgaar Yojnao Ka Pravhaw- Ek Arthik Vishleshan
Authors: डॉ पुष्पेन्द्र  
Published: October 2022

शाहजहाँपुर जिले में बेरोजगारी को दूर करने हेतु एवं इसके समाधान हेतु कई स्वरोजगार योजनाएँ शासन द्वारा चलाई जा रहीं हैं, शिक्षित बेरोजगारी को दूर करने हेतु सभी वर्गों के युवाओं के लिए शासन द्वारा प्रधानमंत्री रोजगार योजना चलाई जा रही है। यह योजना जिले में, जिला व्यापार एवं उद्योग केन्द्र द्वारा संचालित की जा रही है। कई वर्षों से यह योजना जिले की बैंकिंग व्यवस्था पर विपरीत प्रभाव डाल रही है। इसका कारण योजना के तहत् ऋण प्राप्त करने के पश्चात् हितग्राहियों द्वारा ऋणों का पुनर्भुगतान नहीं किया जाना है। योजनान्तर्गत प्रशिक्षण कार्यक्रम में विषय-विशेषज्ञ के रूप में स्थानीय प्रसिद्व व्यापारियों एवं उद्योगपतियों को आमंत्रित किया जाए तथा बाजार प्रबंधन के संदर्भ में विस्तृत जानकारी पशिणार्थियों को विशेष रूप से दिलाई जाए। शासन को औपचारिक शिक्षा संस्थाओं के स्थान पर रोजगार-मूलक प्रशिक्षण केन्द्र स्थापित करने पर बल देना चाहिए। योजनाओं के प्रभावी क्रियान्वयन हेतु प्रशासनिक संगठनों में कर्मचारियों की संख्या बढ़ाई जानी चाहिए। उन्हें प्रेरणा प्रदान करने के लिए विभिन्न प्रेरक उपाय किए जाने चाहिए। योजनांतर्गत प्रशिक्षण हेतु एक सुसंगत माॅडल तैयार किया जाना चाहिए। योजना क्रियान्वयन के प्रत्येक स्तर पर हितग्राहियों एवं कार्यक्रम अधिकारियों दोनों को प्रशिक्षित किया जाना चाहिए।
Impact of the National Amyotrophic Lateral Sclerosis Registry: Analysis of Registry‐funded Research
Authors: Rechtman Lindsay , Brenner Stephan , Wright Marcienne , Ritsick Maggie , Rahman Farhana , Han Moon , Raymond Jaime , Larson Theodore , Horton D. Kevin , Mehta Paul 
Published: October 2022

AbstractObjectiveThis research aims to examine the impact of the National Amyotrophic Lateral Sclerosis (ALS) Registry‐funded research activities.MethodsRegistry‐funded research and related publications were identified through the National ALS Registry website, the National Institutes of Health (NIH) Reporter website, and verified by Principal Investigators. Key study characteristics (e.g., study population, sample size) and key impact features (e.g., risk factors) were abstracted and recorded on study abstraction forms. Descriptive statistics were used to analyze the volume, productivity, and findings of the Registry‐funded research.ResultsSince 2012, the National ALS Registry funded 21 research projects. Of these, 14 were through extramural research grants and included in the analysis. These studies are often related to environmental, medical conditions, and genetic risk factors. On average, the funded grants produced 1 to 2 publications which were cited 114 times by other researchers. The relative citation ratio averaged 1.81 with a weighted relative citation ratio of 16.28. These studies supported the identification and confirmation of candidate risk factors. Environmental and occupational risk factors typically related to heavy metal exposure (e.g., lead, mercury) and agricultural chemicals (e.g., pesticides, herbicides), and the occupations associated with exposure to these substances were most frequently explored.InterpretationThe National ALS Registry is a multifaceted research platform, one component of which is funded research. This Registry‐funded research fills an essential gap in the overall ALS scientific community as it is difficult to prevent and treat a disease without a deeper understanding of its causes.
Less is More: Preorganization Leads to Better Tumor Retention and Therapeutic Efficacy
Authors: Xie Limin , Ding Yinghao , Wang Yuhan , Li Xinxin , Yang Zhimou , Hu Zhi‐Wen 
Published: October 2022

AbstractProtein preorganization is ubiquitous in nature and enables subtle structural rearrangements and precise function executions, making it an attractive approach for generating functional peptide materials. Here, a phosphorylation‐dependent pre‐organization approach to optimize the therapeutic outcomes of a self‐assembling peptide targeting programmed cell death ligand 1 (PD‐L1) is reported. Upon incorporating the imaging probe cyanine 5.5 (Cy5.5) and therapeutic drug 10‐hydroxycamptothecin (HCPT), three phosphorylated precursors (1P, 2P, and 3P) containing identical peptide sequences with different tyrosine phosphorylation sites are constructed. The presence of a phosphate group can stabilize the self‐assembling peptide in a well‐defined, preorganized state. Moreover, variations in the phosphorylation sites lead to different preorganized secondary structures, dephosphorylation rates, and PD‐L1 binding affinities. Responding to alkaline phosphatase dephosphorylation, subtle structural transformation to more ordered states, an increase in binding affinity against PD‐L1, and rapid cellular internalization are observed. Compared with the unphosphorylated control (0P), the preorganization of 1P, 2P, and 3P can optimize tumor retention and resultant therapeutic performance, of which 3P maximizes the final therapeutic outcomes, leading to a 70.3% tumor inhibition rate. This study highlights the great potential to control the subtle structural transformation and therapeutic effects of self‐assembling peptides by preparing their preorganized entities.
Gradient Perovskite Ionic–Electronic Heterointerphases for Deep Cycling Mg Metal Anodes
Authors: Wang Aoxuan , Xue Linlin , Guo Longyuan , Peng Chengxin , Luo Jiayan 
Published: October 2022

AbstractDirect use of metals with low redox potential and high capacity as anodes can enable high energy density batteries. Mg metal has been considered as an ideal anode for its high critical current density and earth‐abundance, but its development has been impeded by the lacking of Mg‐compatible yet cost‐effective electrolyte. Artificial layers that prevent direct Mg‐electrolyte contact while permit Mg2+ to transport through, mitigate the anode–electrolyte incompatibility and allow industrial Li battery electrolyte analog to implement. However, charge transport through these artificial layers remains elusive, let alone to quantitatively design the layer thickness, components, and their distribution. Here it is shown that by using a gradient mixed ion‐electron conducting layer, which is prepared by a transferable perovskite film, the ion/electron transport path can be individually and continually tuned. It is found that a high Coulombic efficiency of 99.2% can be obtained for Mg anode in 0.5 M Mg(TFSI)2/DME electrolyte. It is also shown that long cycling full cells with a low N/P ratio (N/P ≈ 3.42 for Mg|Mo6S8, N/P ≈ 2.06 for Mg|Cu2‐xS) can be achieved. It is suggested that rational interfacial engineering will open new way to design practical Mg metal batteries.
Deoxyribonucleic Acid‐Based Electron Selective Contact for Crystalline Silicon Solar Cells
Authors: Tom Thomas , Ros Eloi , Rovira David , López‐Vidrier Julian , Asensi José Miguel , Ortega Pablo , Puigdollers Joaquim , Voz Cristobal , Bertomeu Joan 
Published: October 2022

AbstractDevelopment of carrier selective contacts for crystalline silicon solar cells has been recently of great interest toward the further expansion of silicon photovoltaics. The use of new electron and hole selective layers has opened an array of possibilities due to the low‐cost processing and non‐doping contacts. Here, a non‐doped heterojunction silicon solar cell without the use of any intrinsic amorphous silicon is fabricated using Deoxyribonucleic acid (DNA) as the electron transport layer (ETL) and transition metal oxide V2O5 as the hole transport layer (HTL). The deposition and characterization of the DNA films on crystalline silicon have been studied, the films have shown a n‐type behavior with a work function of 3.42 eV and a contact resistance of 28 mΩ cm2. This non‐doped architecture has demonstrated a power conversion efficiency of 15.6%, which supposes an increase of more than 9% with respect to the cell not containing the biomolecule, thus paving the way for a future role of nucleic acids as ETLs.
Clustered Regularly Interspaced short palindromic repeats‐Based Microfluidic System in Infectious Diseases Diagnosis: Current Status, Challenges, and Perspectives
Authors: Xie Yi , Li Huimin , Chen Fumin , Udayakumar Srisruthi , Arora Khyati , Chen Hui , Lan Yang , Hu Qinqin , Zhou Xiaonong , Guo Xiaokui , Xiu Leshan , Yin Kun 
Published: October 2022

AbstractMitigating the spread of global infectious diseases requires rapid and accurate diagnostic tools. Conventional diagnostic techniques for infectious diseases typically require sophisticated equipment and are time consuming. Emerging clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR‐associated proteins (Cas) detection systems have shown remarkable potential as next‐generation diagnostic tools to achieve rapid, sensitive, specific, and field‐deployable diagnoses of infectious diseases, based on state‐of‐the‐art microfluidic platforms. Therefore, a review of recent advances in CRISPR‐based microfluidic systems for infectious diseases diagnosis is urgently required. This review highlights the mechanisms of CRISPR/Cas biosensing and cutting‐edge microfluidic devices including paper, digital, and integrated wearable platforms. Strategies to simplify sample pretreatment, improve diagnostic performance, and achieve integrated detection are discussed. Current challenges and future perspectives contributing to the development of more effective CRISPR‐based microfluidic diagnostic systems are also proposed.
Transition‐Metal‐Free Methods for the Remote C−H Bond Functionalization of Cyclic Amines
Authors: Chen Weijie , Cao Xi , Yang Xiaoyu 
Published: October 2022

AbstractC−H bond functionalization is one of the most efficient strategies for the rapid synthesis of cyclic amines containing substituents in the ring, which are core structures of many bioactive molecules. However, it is much more challenging to perform this strategy on remote C−H bonds than on α‐C−H bonds of cyclic amines. This review provides a comprehensive overview on the transition metal‐free methods for the remote C−H bond functionalization of cyclic amines, complementary to methods relying on transition metal catalysis. Selected substrate scope and discussion of reaction mechanism are given when necessary.