bluuebunny/crossref_metadata_2025_split huggingface dataset:
$${{\mathrm {Latent}}Out}$$: an unsupervised deep anomaly detection approach exploiting latent space distribution
Authors: Angiulli Fabrizio , Fassetti Fabio , Ferragina Luca 
Published: May 2022

AbstractAnomaly detection methods exploiting autoencoders (AE) have shown good performances. Unfortunately, deep non-linear architectures are able to perform high dimensionality reduction while keeping reconstruction error low, thus worsening outlier detecting performances of AEs. To alleviate the above problem, recently some authors have proposed to exploit Variational autoencoders (VAE) and bidirectional Generative Adversarial Networks (GAN), which arise as a variant of standard AEs designed for generative purposes, both enforcing the organization of the latent space guaranteeing continuity. However, these architectures share with standard AEs the problem that they generalize so well that they can also well reconstruct anomalies. In this work we argue that the approach of selecting the worst reconstructed examples as anomalies is too simplistic if a continuous latent space autoencoder-based architecture is employed. We show that outliers tend to lie in the sparsest regions of the combined latent/error space and propose the$$\mathrm{VAE}Out$$VAEOutand$${{\mathrm {Latent}}Out}$$LatentOutunsupervised anomaly detection algorithms, identifying outliers by performing density estimation in this augmented feature space. The proposed approach shows sensible improvements in terms of detection performances over the standard approach based on the reconstruction error.
Structural relationships between classroom emotional climate, teacher–student interpersonal relationships and students’ attitudes to STEM
Authors: McLure Felicity I. , Fraser Barry J. , Koul Rekha B. 
Published: May 2022

AbstractRecently, integrated STEM projects have been introduced into school curricula in an attempt to increase students’ understanding and interest in pursuing STEM subjects in senior high school and university. However, little is known about the classroom emotional climate in STEM classrooms and its effect, along with teacher–student interpersonal relationships, on students’ attitudes towards STEM. A validated questionnaire about students’ perceptions of the STEM classroom emotional climate and a simplified version of the questionnaire of teacher-student interpersonal relationships were administered to students completing STEM projects (N = 698). Students also completed a questionnaire about their attitudes towards STEM projects and continuation in the STEM pipeline. Structural equation modelling analysis suggested that the classroom emotional climate together with helping/friendly teacher-student interpersonal relationships have positive influences on student attitudes towards STEM. On the other hand, while teacher-student interpersonal relationships that are understanding or directing have a positive influence on the classroom emotional climate, they have negative influences on students’ attitudes towards STEM and continuing in the STEM pipeline. There are some significant gender differences in teacher-student relationships that influence attitudes towards STEM. This raises some interesting possibilities about how teachers should manage classrooms that integrate STEM skills to complete projects in order to encourage greater participation in STEM subjects.
Outcome of transcatheter aortic valve replacement in patients over 85 years of age versus patients aged 85 and younger
Authors: van den Brink F. S. , Wijtsma I. , Amrane H. , Vossenberg T. N. E. , Haenen J. , Porta F. , Van Boven A. J. , Hofma S. H. 
Published: May 2022

AbstractIntroductionThe Dutch general population is aging rapidly. Many of these patient are fit and eligible for TAVR. However, studies on outcome in older versus younger patients are scant.Material and methodsA single-centre retrospective study comparing patients older and younger than age 85 on outcome.Results190 patients underwent TAVR: 136 were aged 85 or younger (U85), 54 were older than 85 (O85). The U85 group had more men (U85: 71 [52.2%] vs O85: 19 [35.2%];p = 0.034), a higher incidence of diabetes (U85: 36 [26.5%] vs O85: 3 [5.6%];p = 0.001) and atrial fibrillation (U85: 35 [25.7%] vs O85: 5 [9.3%];p = 0.03) and a higher body mass index (U85: 27.5 [± 5.24] vs O85: 26 [± 3.78];p = 0.027). In the O85 group there was a lower estimated glomerular filtration rate (O85: 50.28 [± 15.32] ml/min vs U85: 65.25 [± 29.97] ml/min;p = 0.012). There was no difference in 30-day mortality (U85: 6 [4.4%] vs O85: 3 [5.6%]) and 1‑year mortality (U85 9 [6.6%] vs O85 3 [5.6%]) (p = 0.521). There was an equal amount of new onset permanent left bundle branch block (U85: 38 [27.9%] vs O85: 14 [25.9%];p = 0.896) and permanent pacemaker implantation (U85: 28 [20.6%] vs O85: 28 [20.6%];p = 0.748). There was no difference in bleeding events (p = 0.469), vascular complications (p = 0.195) or moderate/severe regurgitation (p = 0.972). The U85 group had a slightly longer admission duration (U85 6.29 [± 5.289] days vs O85 5.98 [± 3.328] days (p = 0.037)).ConclusionTAVR in patients over 85 years of age has excellent outcome, comparable to those aged 85 and younger.
Prehospital Care (EMS) in Yemen: Brief Report
Authors: Naser Waheeb Nasr , Alsabri Mohammed , Salem Waleed , Yu Rebecca , Ba Saleem Huda 
Published: May 2022

AbstractObjective:A well-organized emergency medical system with adequate prehospital care can save lives and prevent disability. In Yemen, there are no data available about its prehospital care system. This qualitative, cross-sectional study aims to assess the status of prehospital care or emergency medical services in Yemen.Methods:Data were collected from January to February 2019 through interviews and a questionnaire obtained from the Prehospital Trauma Care Systems Guideline published by the World Health Organization (WHO). Respondents were key representatives of the Ministry of Public Health and Population (MoPHP), Civil Defense/Police departments, and Yemeni Red Crescent Association (YRCA).Results:Overall, based on 153 responses, it was found that, despite the availability of some formal services, the prehospital care system in Yemen is uncoordinated, fragmented, and insufficient.Conclusions:Given the importance of regulation, legislation, and funding support in the establishment of an effective prehospital care system, these areas merit the greatest attention and efforts. Future policies and strategies should also strive to improve communication and coordination between existing prehospital care providers, to establish a lead agency, and to increase accessibility to training.
Iterative square roots of functions
Authors: BHAT B. V. RAJARAMA , GOPALAKRISHNA CHAITANYA 
Published: May 2022

AbstractAn iterative square root of a self-mapfis a self-mapgsuch that$g(g(\cdot ))=f(\cdot )$. We obtain new characterizations for detecting the non-existence of such square roots for self-maps on arbitrary sets. They are used to prove that continuous self-maps with no square roots are dense in the space of all continuous self-maps for various topological spaces. The spaces studied include those that are homeomorphic to the unit cube in${\mathbb R}^{m}$and to the whole of$\mathbb {R}^{m}$for every positive integer$m.$However, we also prove that every continuous self-map on a space homeomorphic to the unit cube in$\mathbb {R}^{m}$with a fixed point on the boundary can be approximated by iterative squares of continuous self-maps.
-invariants for planar two-center Stark–Zeeman systems
Authors: CIELIEBAK KAI , FRAUENFELDER URS , ZHAO LEI 
Published: May 2022

AbstractIn this paper, we introduce the notion of planar two-center Stark–Zeeman systems and define four
$J^{+}$
-like invariants for their periodic orbits. The construction is based on a previous construction for a planar one-center Stark–Zeeman system in [K. Cieliebak, U. Frauenfelder and O. van Koert. Periodic orbits in the restricted three-body problem and Arnold’s
$J^+$
-invariant. Regul. Chaotic Dyn.22(4) (2017), 408–434] as well as Levi-Civita and Birkhoff regularizations. We analyze the relationship among these invariants and show that they are largely independent, based on a new construction called interior connected sum.
The Influence of Equation of State on the Giant Impact Simulations
Authors: Hosono Natsuki , Karato Shun‐ichiro 
Published: May 2022

AbstractWe explore the role of various equations of state (EoS) in controlling the composition of the Moon formed by a giant impact (GI) using a density‐independent SPH code. A limitation in our previous model Hosono et al. (2019), https://doi.org/10.1038/s41561-019-0354-2 is improved by replacing the EoS of the solid from Tillotson EoS to M‐ANEOS, and we also explored two recently proposed EoSs by Stewart et al. (2020), https://doi.org/10.1063/12.0000946 and Wissing and Hobbs (2020a), https://doi.org/10.1051/0004-6361/201935814; Wissing and Hobbs (2020b), https://doi.org/10.1051/0004-6361/201936227. The goal is to investigate to what extent we can explain the observed composition of the Moon including the similarity in the isotopic composition and the dissimilarity in the FeO/(FeO + MgO) ratio as compared to that of Earth by the different types of EoS assuming the conventional collision conditions. We found that changing the EoS for solids from Tillotson to M‐ANEOS EoS resolves the issues of latent heat, but its effect on the composition of the disk is small compared to the influence of the hard‐sphere EoS of magma ocean in controlling the composition of the disk. Similarly, two recently proposed EoSs have small effects on the composition of the disk in comparison to the model where the hard‐sphere EoS is used for preexisting magma ocean. We attribute this difference to a fundamental difference in thermodynamic behavior of silicate melts captured by the hard‐sphere EoS and by newly proposed EoSs; in the hard‐sphere model of silicate melts, configurational entropy dominates in free energy, whereas in the newly proposed model, entropy is dominated by vibrational entropy similar to entropy of solids.
Distribution of Negative J·E′ in the Inflow Edge of the Inner Electron Diffusion Region During Tail Magnetic Reconnection: Simulations Vs. Observations
Authors: Xiong Q. Y. , Huang S. Y. , Zhou M. , Yuan Z. G. , Deng X. H. , Jiang K. , Wei Y. Y. , Xu S. B. , Zhang J. , Lin R. T. , Yu L. 
Published: May 2022

AbstractMagnetic reconnection is a universal phenomenon existing in the space. Energy conversion is one of the essential parts of reconnection discussed for decades. Positive energy conversion (J·E′ > 0) is usually regarded as the sign of electron diffusion region (EDR), while the negative one (J·E′ < 0) turns out to gather in the outer EDR. Here we report the negative J·E′ appearing in the inflow edge of the inner EDR, based on Magnetospheric Multiscale mission observations and particle‐in‐cell simulations. Both observations and simulations verify that this negative J·E′ is mainly contributed from the electron pressure tensor term in generalized Ohm's law. The energy loss of electrons plays the dominant effect in the electron pressure tensor, and this energy decline is caused by the electric field which is induced by the decreasing magnetic field. Our results provide significant insights to expand the understanding of the reconnection regimes.
Hazy Blue Worlds: A Holistic Aerosol Model for Uranus and Neptune, Including Dark Spots
Authors: Irwin P. G. J. , Teanby N. A. , Fletcher L. N. , Toledo D. , Orton G. S. , Wong M. H. , Roman M. T. , Pérez‐Hoyos S. , James A. , Dobinson J. 
Published: May 2022

AbstractWe present a reanalysis (using the Minnaert limb‐darkening approximation) of visible/near‐infrared (0.3–2.5 μm) observations of Uranus and Neptune made by several instruments. We find a common model of the vertical aerosol distribution i.e., consistent with the observed reflectivity spectra of both planets, consisting of: (a) a deep aerosol layer with a base pressure >5–7 bar, assumed to be composed of a mixture of H2S ice and photochemical haze; (b) a layer of photochemical haze/ice, coincident with a layer of high static stability at the methane condensation level at 1–2 bar; and (c) an extended layer of photochemical haze, likely mostly of the same composition as the 1–2‐bar layer, extending from this level up through to the stratosphere, where the photochemical haze particles are thought to be produced. For Neptune, we find that we also need to add a thin layer of micron‐sized methane ice particles at ∼0.2 bar to explain the enhanced reflection at longer methane‐absorbing wavelengths. We suggest that methane condensing onto the haze particles at the base of the 1–2‐bar aerosol layer forms ice/haze particles that grow very quickly to large size and immediately “snow out” (as predicted by Carlson et al. (1988), https://doi.org/10.1175/1520-0469(1988)045<2066:CMOTGP>2.0.CO;2), re‐evaporating at deeper levels to release their core haze particles to act as condensation nuclei for H2S ice formation. In addition, we find that the spectral characteristics of “dark spots”, such as the Voyager‐2/ISS Great Dark Spot and the HST/WFC3 NDS‐2018, are well modelled by a darkening or possibly clearing of the deep aerosol layer only.
Enzymatically amplified linear dbDNATM as a rapid and scalable solution to industrial lentiviral vector manufacturing
Authors: Barreira Maria , Kerridge Claire , Jorda Sara , Olofsson Didrik , Neumann Alexander , Horton Helen , Smith-Moore Sarah 
Published: May 2022

AbstractTraditional bacterial fermentation techniques used to manufacture plasmid are time-consuming, expensive, and inherently unstable. The production of sufficient GMP grade material thus imposes a major bottleneck on industrial-scale manufacturing of lentiviral vectors (LVV). Touchlight’s linear doggybone DNA (dbDNATM) is an enzymatically amplified DNA vector produced with exceptional speed through an in vitro dual enzyme process, enabling industrial-scale manufacturing of GMP material in a fraction of the time required for plasmid. We have previously shown that dbDNATM can be used to produce functional LVV; however, obtaining high LVV titres remained a challenge. Here, we aimed to demonstrate that dbDNATM could be optimised for the manufacture of high titre LVV. We found that dbDNATM displayed a unique transfection and expression profile in the context of LVV production, which necessitated the optimisation of DNA input and construct ratios. Furthermore, we demonstrate that efficient 3’ end processing of viral genomic RNA (vgRNA) derived from linear dbDNATM transfer vectors required the addition of a strong 3’ termination signal and downstream spacer sequence to enable efficient vgRNA packaging. Using these improved vector architectures along with optimised transfection conditions, we were able to produce a CAR19h28z LVV with equivalent infectious titres as achieved using plasmid, demonstrating that dbDNATM technology can provide a highly effective solution to the plasmid bottleneck.
Experimental implementation of a neural network optical channel equalizer in restricted hardware using pruning and quantization
Authors: Ron Diego Argüello , Freire Pedro J. , Prilepsky Jaroslaw E. , Kamalian-Kopae Morteza , Napoli Antonio , Turitsyn Sergei K. 
Published: May 2022

AbstractThe deployment of artificial neural networks-based optical channel equalizers on edge-computing devices is critically important for the next generation of optical communication systems. However, this is still a highly challenging problem, mainly due to the computational complexity of the artificial neural networks (NNs) required for the efficient equalization of nonlinear optical channels with large dispersion-induced memory. To implement the NN-based optical channel equalizer in hardware, a substantial complexity reduction is needed, while we have to keep an acceptable performance level of the simplified NN model. In this work, we address the complexity reduction problem by applying pruning and quantization techniques to an NN-based optical channel equalizer. We use an exemplary NN architecture, the multi-layer perceptron (MLP), to mitigate the impairments for 30 GBd 1000 km transmission over a standard single-mode fiber, and demonstrate that it is feasible to reduce the equalizer’s memory by up to 87.12%, and its complexity by up to 78.34%, without noticeable performance degradation. In addition to this, we accurately define the computational complexity of a compressed NN-based equalizer in the digital signal processing (DSP) sense. Further, we examine the impact of using hardware with different CPU and GPU features on the power consumption and latency for the compressed equalizer. We also verify the developed technique experimentally, by implementing the reduced NN equalizer on two standard edge-computing hardware units: Raspberry Pi 4 and Nvidia Jetson Nano, which are used to process the data generated via simulating the signal’s propagation down the optical-fiber system.
Briquetting of subbituminous coal and torrefied biomass using bentonite as inorganic binder
Authors: Adeleke A. A. , Odusote J. K. , Ikubanni P. P. , Olabisi A. S. , Nzerem P. 
Published: May 2022

AbstractThe use of inorganic binder for briquetting of subbituminous coal and torrefied biomass for energy generation is scarce. The present study focuses on the physicomechanical durability and energy content of briquettes produced from subbituminous coal (SubC) and torrefied biomass (TM) using bentonite as binder. Briquettes were produced using 95% SubC and 5% TM. Bentonite was varied at 2–10% of the total SubC and TM weight. The briquettes were produced with a constant pressure (28 MPa) in a hydraulic press. The briquettes were primarily cured at room temperature and then at 300 $$^\circ{\rm C}$$

∘

C

in a tubular furnace under an inert condition for 60 min. The density and water resistance (WRI) of the briquettes were evaluated. Drop to fracture (DF), impact resistance index (IRI), cold crushing strength (CCS) and tumbling strength index (TSI+3 mm) of the briquette were obtained. The reactivity index (RI), proximate, ultimate and calorific values analyses were assessed based on different ASTM standards. Microstructural studies and elemental mapping were carried out using scanning electron microscope equipped with EDS and electron probe microanalyzer. The density increased with increment in bentonite content. The WRI decreased with increase in bentonite while the least (95.21%) was obtained at 10% binder content. The DF and IRI ranges from 100 to 150 and 2000–3000, respectively. The CCS were in the range of 19.71 to 40.23 MPa. The RI varies from 34 to 50%. Fixed carbon, carbon and calorific values were impaired as the bentonite content in the briquette increases. Oxygen and silica bridges with mechanical interlocking were observed on the micrographs of the briquettes. The briquettes produced with 2% bentonite content have better physicomechanical durability with equivalent energy content. It is recommended as feedstock for thermal and metallurgical applications.
7-Methoxyisoflavone ameliorates atopic dermatitis symptoms by regulating multiple signaling pathways and reducing chemokine production
Authors: Dong Hao , Feng Chenjie , Cai Xiyunyi , Hao Yuanyuan , Gu Xinyue , Cai Lei , Wu Shuting , Chen Jiamin , Liu Zhou , Xie Wen , Lu Xuanren , Qian Hongfa , Liu Yulin , Cao Yiming , Zhu Junlin , Xu Jiayi , Zhou Yanjie , Ma Shuangyu , Yang Sha , Shi Yufeng , Yu Haojiang , Shi Minjie , Wang Yurong , Gu Harvest F. , Fan Lei , Wu Liang 
Published: May 2022

Abstract7-Met, a derivative of soybean isoflavone, is a natural flavonoid compound that has been reported to have multiple signaling pathways regulation effects. This study investigated the therapeutic effects of 7-Met on mice with atopic dermatitis induced by fluorescein isothiocyanate (FITC), or oxazolone (OXZ). 7-Met ameliorated FITC or OXZ-induced atopic dermatitis symptoms by decreasing ear thickness, spleen index, mast cell activation, neutrophil infiltration and serum IgE levels in female BALB/c mice. In FITC-induced atopic dermatitis mice, 7-Met reduced Th1 cytokines production and regulated Th1/Th2 balance by downregulating the secretion of thymic stromal lymphopoietin (TSLP) via inactivation of the NF-κB pathway. In OXZ-induced atopic dermatitis, 7-Met functioned through the reduction of Th17 cytokine production. Our study showed that 7-Methoxyisoflavone alleviated atopic dermatitis by regulating multiple signaling pathways and downregulating chemokine production.
Effective hole conductivity in nitrogen-doped CVD-graphene by singlet oxygen treatment under photoactivation conditions
Authors: Bianco Giuseppe Valerio , Sacchetti Alberto , Grande Marco , D’Orazio Antonella , Milella Antonella , Bruno Giovanni 
Published: May 2022

AbstractNitrogen substitutional doping in the π-basal plane of graphene has been used to modulate the material properties and in particular the transition from hole to electron conduction, thus enlarging the field of potential applications. Depending on the doping procedure, nitrogen moieties mainly include graphitic-N, combined with pyrrolic-N and pyridinic-N. However, pyridine and pyrrole configurations of nitrogen are predominantly introduced in monolayer graphene:N lattice as prepared by CVD. In this study, we investigate the possibility of employing pyridinic-nitrogen as a reactive site as well as activate a reactive center at the adjacent carbon atoms in the functionalized C–N bonds, for additional post reaction like oxidation. Furthermore, the photocatalytic activity of the graphene:N surface in the production of singlet oxygen (1O2) is fully exploited for the oxidation of the graphene basal plane with the formation of pyridine N-oxide and pyridone structures, both having zwitterion forms with a strong p-doping effect. A sheet resistance value as low as 100 Ω/□ is reported for a 3-layer stacked graphene:N film.
Activation of Gαq sequesters specific transcripts into Ago2 particles
Authors: Jackson Lela , Rennie Madison , Poussaint Alison , Scarlata Suzanne 
Published: May 2022

AbstractThe Gαq/phospholipase Cβ1 (PLCβ1) signaling system mediates calcium responses from hormones and neurotransmitters. While PLCβ1 functions on the plasma membrane, there is an atypical cytosolic population that binds Argonaute 2 (Ago2) and other proteins associated with stress granules preventing their aggregation. Activation of Gαq relocalizes cytosolic PLCβ1 to the membrane, releasing bound proteins, promoting the formation of stress granules. Here, we have characterized Ago2 stress granules associated with Gαq activation in differentiated PC12 cells, which have a robust Gαq/PLCβ1 signaling system. Characterization of Ago2-associated stress granules shows shifts in protein composition when cells are stimulated with a Gαq agonist, or subjected to heat shock or osmotic stress, consistent with the idea that different stresses result in unique stress granules. Purified Ago2 stress granules from control cells do not contain RNA, while those from heat shock contain many different mRNAs and miRs. Surprisingly, Ago2 particles from cells where Gαq was stimulated show only two transcripts, chromogranin B, which is involved in secretory function, and ATP synthase 5f1b, which is required for ATP synthesis. RT-PCR, western blotting and other studies support the idea that Gαq-activation protects these transcripts. Taken together, these studies show a novel pathway where Gαq/PLCβ regulates the translation of specific proteins.
On the role of citrate in 12-molybdophosphoric-acid methods for quantification of phosphate in the presence of ATP
Authors: Recoulat Angelini Alvaro A. , Martínez Gache Santiago A. , Sabeckis M. Lurdes , Melian Noelia A. , González Flecha F. Luis 
Published: May 2022

Citrate is a useful additive for measuring ATPase activities avoiding the interference of phosphate release after catalysis. In this work we explore this effect, and optimize the malachite green procedure for determination of phosphate.