bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of dietary protein sources and their adequacy on muscle function, body composition, and risk of sarcopenic obesity in South Korean populations: A cross-sectional study
Authors: Kim Jieun , Jeong Kyoungsik , Lim Sueun , Lee Siwoo , Baek Younghwa 
Published: September 2022

Abstract
Background

Dietary protein sources and protein adequacy are crucial modulators of muscle quality and body composition. We investigated the association between dietary protein sources (and their adequacy) and prevalence of sarcopenic obesity (SO) in South Korean populations according to weight status.

Methods

The participants (n = 1,967) were classified into SO, obese, sarcopenia, and normal groups. A cross-sectional survey was conducted using the KS-15 questionnaire, short-form Food Frequency Questionnaire, and anthropometric measurements.

Results

Percentage of body fat (male: 28.43 ± 0.61%; female: 39.95 ± 0.36%) was significantly high, while appendicular skeletal muscle (ASM; male: 40.30 ± 0.36%, female: 32.47 ± 0.20%) was low in the SO and OB groups. Beef and pork consumption was negatively associated with ASM (%) but positively associated with body fat (kg and %) in the normal group. Among the people with excessive protein intake, the lowest quintile (Q1: 5.7 g/day) of beans and tofu consumption showed a 2.4-fold increase in the risk of developing SO (adjusted odds ratio: 2.41, confidence interval: 1.07–7.80), when compared with the highest quintile (Q5: 60.1 g/day). Similarly, with beans and tofu consumption, there was a 2.5-fold higher risk of developing sarcopenia in participants who had < 5.7 g/day intake in the excessive protein intake individuals.

Conclusions

Daily poultry and egg intake was positively linked with muscle function in the participants with sarcopenia, while red meat showed a negative effect on imbalanced body composition with increased fat mass (kg and %) and decreased ASM (%) in participants with normal weight. Furthermore, lower intake of healthy protein foods, such as beans and tofu or poultry and eggs, was strongly associated with SO prevalence in people who consumed excessive daily dietary protein.
Tecnologias digitais como mediadoras da aprendizagem nas séries iniciais
Authors: Silva Danubia Cauana Zarur da , Santos Lielta Cardozo dos , Rauta Marineide Pereira , Nepomoceno Taiane Aparecida Ribeiro 
Published: September 2022

O objetivo deste artigo foi descrever os aspectos do uso das tecnologias digitais nas séries iniciais, do ensino fundamental I. Para tanto foi utilizada a metodologia de pesquisa qualitativa, de caráter exploratório e desenvolvida a partir da técnica de revisão de literatura narrativa de artigos científicos. Para a coleta de materiais foram consultadas duas bases de dados, a citar: Portal de Periódicos da Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) e Google Scholar. Foram incluídos apenas artigos científicos publicados em periódicos, a partir de 2015 e em língua portuguesa. Os cinco artigos analisados são coerentes as afirmar que as tecnologias digitais são recursos facilitadores da prática docente, trazendo inovação para as aulas e melhorias, especialmente, nas abordagens dos conteúdos curriculares. Assim, as tecnologias digitais, podem ser entendidas como ferramentas didáticas, intermediadoras nos processos de ensino e aprendizagem, na abordagem, aperfeiçoamento de conteúdos curriculares das séries iniciais e no desenvolvimento de um sistema educativo moderno, contudo precisam de subsídios públicos, formativos e técnicos.
Perfil Epidemiológico da Tuberculose no Estado de Pernambuco nos Últimos Dez Anos
Authors: Gomes da Silva Wenys Claudio , Chaves Amanda Maria , Júnior Irani de Farias Cunha 
Published: September 2022

RESUMO
Apesar da transição no perfil epidemiológico, a tuberculose ainda continua como um sério entrave à saúde pública em todo mundo. No Brasil, o estado de Pernambuco está entre as capitais que possuem um coeficiente de mortalidade por essa doença maior do que o coeficiente do país. O trabalho tem como objetivo estabelecer o perfil epidemiológico da doença Tuberculose no estado de Pernambuco nos últimos 10 anos. O presente estudo se caracteriza por ser Ecológico Retrospectivo, utilizado para medir a prevalência de doenças e útil para o planejamento em saúde. A coleta de dados foi realizada de forma secundária através da divisão de Tuberculose - Casos confirmados e notificados no Sistema de Informação de agravos de notificação – Pernambuco no TABWIN-PE. O número de casos através dos anos aparece alto e constante, sendo o ano de 2019 o que alcançou mais casos, com um total de 6.166, o que representa um aumento de 11,8% ao ano com menos casos que foi 2010. Foi observado que o Perfil Pernambucano nos últimos 10 anos foi análogo ao de diversos estudos e também se esclareceu a importância de medidas de prevenção focadas nas populações encontradas. O alto índice de novos diagnósticos pela tuberculose em Pernambuco, durante os anos de 2010 a 2019, mostra transparência no Sistema de Notificação, visto que a subnotificação é um fator apontado por vários autores.
PALAVRAS-CHAVE: Tuberculose, Saúde Coletiva, Epidemiologia.
Análise dos efeitos adversos do uso off-label do metilfenidato por estudantes para aperfeiçoamento cognitivo: uma revisão da integrativa
Authors: Lima da Silva Andressa , Teixeira Kuhn Fábio , De Oliveira Machado Liss Andria 
Published: September 2022

O cloridrato de metilfenidato, também conhecido como Ritalina®, é um fármaco estimulante do sistema nervoso central (SNC) que provoca a aceleração do funcionamento mental e cognitivo. Esta pesquisa tem como objetivo investigar a utilização do metilfenidato sem prescrição médica com o intuito de aumento da cognição e também as possíveis causas e efeitos no organismo de estudantes através de pesquisas, especificamente, pretende-se verificar estudos acerca dos efeitos a longo prazo do metilfenidato. O presente estudo foi baseado em pesquisas bibliográficas de artigos publicados entre os anos de 2000 e 2020, em bases de dados como SciELO, PubMed e Google Acadêmico. Foram encontrados quatorze artigos onde são abordados os efeitos adversos relacionados ao uso indiscriminado do cloridrato de metilfenidato por acadêmicos, uso off-label, adição relacionada ao abuso deste fármaco e o mecanismo de ação dos medicamentos psicoativos. Os resultados evidenciaram que nos últimos anos o consumo off-label de psicoestimulantes por estudantes com o intuito de incrementar a função cognitiva vem aumentando, esse tipo de consumo não é aprovado, pois além da eficácia ser contestada, o uso indiscriminado pode ocasionar graves efeitos adversos ao indivíduo. Com isso, ressalta-se que o uso de quaisquer medicamentos, principalmente, psicoestimulantes, devem ser utilizados apenas com acompanhamento médico. Portanto, torna-se necessária a criação de políticas públicas que visem mitigar essa problemática no Brasil.
The Resilience of Pseudomonas aeruginosa to Antibiotics and the
Designing of Antimicrobial Peptides to Overcome Microbial Resistance
Authors: Juárez-López Daniel , Morales-Ruiz Estefanía , Herrera-Zúñiga Leonardo D. , González-Carrera Zuriel , Cuevas-Reyes Elizabeth , Corzo Gerardo , Schcolnik-Cabrera Alejandro , Villegas Elba 
Published: September 2022

Abstract:
Pseudomonas aeruginosa (P. aeruginosa) is a bacterium of medical concern, known for its potential to persist in diverse environments due to its metabolic capacity. Its survival ability is linked to its relatively large genome of 5.5-7 Mbp, from which several genes are employed in overcoming conventional antibiotic treatments and promoting resistance. The worldwide prevalence of antibiotic-resistant clones of P. aeruginosa necessitates novel approaches to researching their multiple resistance mechanisms, such as the use of antimicrobial peptides (AMPs). In this review, we briefly discuss the epidemiology of the resistant strains of P. aeruginosa and then describe their resistance mechanisms. Next, we explain the biology of AMPs, enlist the present database platforms that describe AMPs, and discuss their usefulness and limitations in treating P. aeruginosa strains. Finally, we present 13 AMPs with theoretical action against P. aeruginosa, all of which we evaluated in silico in this work. Our results suggest that the AMPs we evaluated have a carpet-like mode of action with a membranolytic function in Gram-positive and Gram-negative bacteria, with clear potential of synthesis for in vitro evaluation.
Opioid-Free Anaesthesia Improves Anaesthesia Recovery when
Compared with that of Opioid-Based Anaesthesia. Systematic
Review and Meta-Analysis of Clinical Trials
Authors: Malo-Manso Alfredo , Fontaneda-Heredia Ana , Romero-Molina Salvador , Sepúlveda-Haro Enrique , Escalona-Belmonte Juan José , Guerrero-Orriach José Luis 
Published: September 2022

Introduction:
Opioid free anesthesia (OFA) is a relatively new technique that
has been questioned due to the lack of evidence regarding its benefit-risk balance.

Methods:
Four international databases were searched for clinical trials comparing OFA
with opioid based anesthesia. The primary outcome was pain control and the secondary
included postoperative nausea and vomiting (PONV), gastrointestinal recovery, respiratory
depression, urinary retention, length of hospital stay, surgical complications, number
of patients with cessation of the intervention and other side effects.

Results:
Pain was better controlled in the OFA group in all the measurements made
(VAS 1h: Md= -0.81, CI95%= -0.48- -1.14, VAS 24h: Md= -1.25,CI95%=-2.41- -0.1,
VAS >24h: Md= -1.36, CI95%= -1.73- -1). In the opioid group there was an increase in
the risk of nausea (RR=2.69, CI95%=2-3.61) and vomiting (RR= 3.99,
CI95%=2.06-7.74), whilst in the OFA group, there was an increased risk of bradycardia
(RR=1.62, CI95%=1.02-2.57). The rest of the variables showed no differences between
groups or could not be analyzed.

Conclusion:
There is a clear benefit of OFA in pain control and PONV, but there is also
a higher risk of bradycardia. This technique should be considered in patients with a special
risk of difficult postoperative pain control or PONV. However, the best drug combination
to perform OFA is still unknown, as well as the type of patient that benefits more
with less risk.
A Systematic Review of the Therapeutic Potential of Resveratrol During
Colorectal Cancer Chemotherapy
Authors: Wu Xiao-Yu , Zhai Jing , Huan Xiang- Kun , Xu Wen-Wen , Tian Jun , Farhood Bagher 
Published: September 2022

Background:
The chemotherapy modality is generally used for treating colorectal cancer.
However, the clinical application of chemotherapeutic drugs may be limited due to their adverse
effects on normal cells/tissues and the development of cancer resistance. Using the combined
treatment of chemotherapy drugs and natural bioactive compounds (such as resveratrol) can
alleviate adverse drug reactions and induce synergies between the drugs.

Objective:
In the current review, the potential therapeutic impacts of resveratrol during colorectal
cancer chemotherapy were studied.

Methods:
Based on the PRISMA guideline, we performed a systematic search in different electronic
databases up to May, 2021. Following the search, 321 papers were found and then screened
for eligibility. Twenty-seven papers were finally included in the present study

Results:
Compared to the control group, the growth inhibition of cancerous cells treated with
chemotherapeutic drugs was considerably higher, and resveratrol co-administration synergistically
increased chemotherapy-induced cytotoxicity. Moreover, a reduction in the tumor weight, volume
and growth of mice was observed following chemotherapy administration compared to the untreated
groups, and these reductions were predominant in animals treated with resveratrol plus chemotherapy.
Other findings showed that chemotherapy alone and in combination with resveratrol modulated
the cell cycle profile of cancerous cells. Furthermore, chemotherapy treatment induced a set of biochemical
and histopathological alterations in cancer cells/tissues, and these changes were synergized
following resveratrol co-treatment (in most of the cases), excluding inflammatory mediators.

Conclusions:
In most cases, resveratrol co-administration could sensitize cancerous cells to chemotherapy
drugs through its oxidant, apoptosis, anti-inflammatory activities, etc. Nevertheless, suggesting the
use of resveratrol during chemotherapy of colorectal cancer patients requires further clinical studies.
Anticancer Properties of Kaempferol on Cellular Signaling Pathways
Authors: Sengupta Bidisha , Biswas Pragnya , Roy Debarshi , Lovett Justin , Simington Laken , Fry Darrell R. , Travis Kaelin 
Published: September 2022

Abstract:Polyhydroxy compounds are secondary metabolites that are ubiquitous in plants of high-er genera. They possess therapeutic properties against a wide spectrum of diseases, including can-cers, neurodegenerative disorders, atherosclerosis, as well as cardiovascular disease. The phyto-chemical flavonol (a type of flavonoid) kaempferol (KMP) (3,5,7-trihydroxy-2-(4-hydroxyphenyl)-4Hchromen-4-one) is abundant in cruciferous vegetables, including broccoli, kale, spinach, and wa-tercress, as well as in herbs like dill, chives, and tarragon. KMP is predominantly hydrophobic in nature due to its diphenylpropane structure (a characteristic feature of flavonoids). Recent findings have indicated the promise of applying KMP in disease prevention due to its potential antioxidant, antimutagenic, antifungal, and antiviral activities. In the literature, there is evidence that KMP ex-erts its anticancer effects by modulating critical elements in cellular signal transduction pathways linked to apoptosis, inflammation, angiogenesis, and metastasis in cancer cells without affecting the viability of normal cells. It has been shown that KMP triggers cancer cell death by several mecha-nisms, including cell cycle arrest, caspase activation, metabolic alteration, and impacting human te-lomerase reverse-transcriptase gene expression. This review is aimed at providing critical insights into the influence of KMP on the intracellular cascades that regulate metabolism and signaling in breast, ovarian, and cervical cancer cells.
Combination Therapy for the Treatment of Alzheimer’s Disease: Recent
Progress and Future Prospects
Authors: Shirbhate Ekta , Patel Vijay K. , Tiwari Priya , Kore Rakesh , Veerasamy Ravichandran , Mishra Achal , Rajak Harish 
Published: September 2022

Background:
The management of Alzheimer’s disease is challenging due to its complexity. However, the currently approved and marketed treatments for this neurodegenerative disorder revolves around cholinesterase inhibitors and glutamate regulators or the combination of these agents. Despite the prompt assurance of many new drugs, several agents were unsuccessful, especially in phase II or III trials, not meeting efficacy endpoints.

Objective:
The execution of effective treatment approaches through further trials investigating a rational combination of agents is necessitude for Alzheimer’s disease.

Method:
For this review, more than 248 relevant scientific papers were considered from a variety of databases (Scopus, Web of Science, Google Scholar, Sciencedirect, and Pubmed) using the keywords Alzheimer’s disease, amyloid-β, combination therapies, cholinesterase inhibitors, dementia, glutamate regulators, AD hypothesis.

Result and Discussion:
The researcher's intent for either developing a disease-modifying therapeutic means for aiming in the early phases of dementia and/or optimizing the available symptomatic treatments principally committed to the more advanced stages of Alzheimer’s. Since Alzheimer possesses multifactorial pathogenesis, designing a multimodal therapeutic intervention for targeting different pathological processes of dementia may appear to be the most practical method to alter the course of disease progression.

Conclusion:
The combination approach may even allow for providing individual agents in lower doses, with reducible cost and side effects. Numerous studies on combination therapy predicted better clinical efficacy than monotherapy. The below literature review highlights the major clinical studies (both symptomatic and disease-modifying) conducted in the past decade on combination therapy to combat the cognitive disorder.
A Review on Computational Analysis of Big Data in Breast Cancer for Predicting Potential Biomarkers
Authors: Shaikh Nilofer , Bapat Sanket , Karthikeyan Muthukumarasamy , Vyas Renu 
Published: September 2022

Abstract:
Breast cancer is the most predominantly occurring cancer in the world. Several genes and
proteins have been recently studied to predict biomarkers that enable early disease identification and
monitor its recurrence. In the era of high-throughput technology, studies show several applications
of big data for identifying potential biomarkers. The review aims to provide a comprehensive overview
of big data analysis in breast cancer towards the prediction of biomarkers with emphasis on
computational methods like text mining, network analysis, next-generation sequencing technology
(NGS), machine learning (ML), deep learning (DL), and precision medicine. Integrating data from
various computational approaches enables the stratification of cancer patients and the identification
of molecular signatures in cancer and their subtypes. The computational methods and statistical
analysis help expedite cancer prognosis and develop precision cancer medicine (PCM). As a part of
case study in the present work, we constructed a large gene-drug interaction network to predict new
biomarkers genes. The gene-drug network helped us to identify eight genes that could serve as novel
potential biomarkers.
Validation of a Method to Measure the T2 Value from the Color Mapping
by Hue Value
Authors: Hananouchi Takehito , Nakayama Makishi 
Published: September 2022

Background:
Color mapping using quantitative MRI (Magnetic Resonance Imaging) is now being reported in various medical fields to be useful in showing tissue conditions and morphological perspectives. Specifically, T2 mapping as one of the color mapping has been used to describe cartilage conditions in orthopedics. However, for orthopedic physicians in out-patient clinics, the color mapping shows only the colors on the mapping to patients without explaining their numerical values.

Methods:
To address this issue, our study proposed an approach to measure T2 values based on the hue value converted from Red, Green, Blue information on the processed color map. We evaluated the validity of our method with 25 subjects.

Results:
Our proposed method showed a good and high correlation coefficient (r = 0.9924, p < 0.0001), and the difference of the T2 values between using a dedicated software on console of MRI scanner and our method was small (its absolute value was approximately 1.5, p = 0.008).

Conclusion:
Therefore, we consider the proposed method is an alternative approach to show the T2 value when the color mapping are available.
Tailoring Physicochemical Properties of Iloperidone by Cocrystallization:
Design and Characterization of Novel Cocrystals of Iloperidone and 4-
amino Benzoic Acid
Authors: Rani Earle Radha , Radha Gadela Venkata 
Published: September 2022

Background:
The current study explores the enhancement of solubility and dissolution rate of a poorly water-soluble drug Iloperidone (IPD) by synthesizing co-crystals (CC) using 4- amino benzoic acid (ABA) as a coformer.

Methods:
Pharmaceutical CCs of IPD with ABA were designed and synthesized using crystal engi-neering. CCs were prepared by solvent evaporation (SE) technique and studied for their enhance-ment in solubility and dissolution rate. CC formation was confirmed by Fourier Transform Infra-Red Spectroscopy (FTIR), powder X-ray diffraction (PXRD), Differential Scanning Calorimetry (DSC), and Proton Nuclear Magnetic Resonance (1H- NMR).

Results:
Structural characterization studies exhibited new characteristic peaks, which confirmed that CCs could be generated from IPD and ABA using SE technique. The apparent aqueous solu-bility studies of the CCs exhibited 7.1 folds increase in solubility compared to the pure drug. Im-provement in the rate of dissolution of CCs was evident from the in vitro dissolution studies, where CCs displayed 94.15 ± 0.27% drug release in 60min while pure drug showed only 39.90 ± 1.86% release in the same time period.

Conclusion:
CCs of IPD and ABA provide a novel approach to overcoming the solubility issues.
Carbapenem Antibiotics: Recent Update on Synthesis and Pharmacological
Activities
Authors: Tiwari Abhishek , Tiwari Varsha , Sahoo Biswa Mohan , Banik Bimal Krishna , Kumar Manish , Verma Navneet 
Published: September 2022

Abstract:
Right from the breakthrough of carbapenems since 1976, many schemes on synthesis, structure-activity relationship (SAR), and biological activities have been carried out, and several carbapenems have been developed, including parentally active carbapenems like imipenem, doripenem, biapenem, meropenem, ertapenem,	panipenem, razupenem, tomopenem, cilastatin, whereas orally active carbapenems like GV-118819, GV-104326, CS-834, L-084, DZ-2640, CL 191, 121, L-646, 591, S-4661, ER-35768, MK-826. Prodrugs of carbapenem with increased bioavailability include temopenem, tebipenem, sanfetrinem, LK-157, and CP 5484. Merck, Glaxo Welcome Research Group, Johnson & Johnson, Sankyo Group and Dai-ichi Group, and Wyeth-Ayerst Group were among the businesses that produced carbapenems. The Witting reaction, Mitsunobu reaction, Dieckmann reaction, palladium-catalyzed hydrogenolysis, E. coli-based cloned synthesis, and biosynthetic enzymes such as carbapenem synthetase (carA), carboxymethylproline synthase (carB), carbapenem synthase (carC). Carbapenems are biologically in infections like urinary tract infections, bloodstream infections, tuberculosis, intra-abdominal infections, and pathogens like anaerobes, gram-positive and gram-negative bacteria.
Study on anticorrosion properties of reduced graphene oxide reinforced waterborne epoxy coating
Authors: Guan Jiyuan , Ye Yin , Li Duosheng , Ye Zhiguo , Jiang Wugui , Qin Qing H. 
Published: September 2022

Background:
The traditional epoxy zinc-rich coating releases some harmful substances such as VOC during the service process, which pollutes the environment and causes great harm to people. Waterborne epoxy coating is an environmentally friendly, non-polluting potential coating.

Objective:
In this paper, a new reduced graphene oxide (RGO) reinforced waterborne epoxy coating is developed.

Methods:
Reduced graphene oxide (RGO) is obtained by modifying graphene oxide (GO). The addition of RGO to waterborne epoxy coatings is designed to improve the corrosion resistance of the coatings. The anticorrosion properties of the coating are investigated by electrochemical methods.

Results:
After the coating was immersed in 3.5wt% NaCl solution for 15 days, the corrosion current of the coating without RGO is greater than that of the coating containing RGO. Coatings with RGO have higher impedance modulus than coatings without RGO. Coating with 0.3% RGO has better corrosion resistance. After the coating was immersed in the salt solution for 55 days, the impedance modulus of the coating with 0.3% RGO increased by 349.11% compared to the coating without RGO. The coating with 0.3% RGO has the minimum corrosion current density, and the maximum polarization resistance and corrosion voltage.

Conclusion:
The waterborne epoxy coating with 0.3% RGO has the best anticorrosion.