bluuebunny/crossref_metadata_2025_split huggingface dataset:
True triaxial experimental study on the influence of axial pressure on coal permeability
Authors: Liu Jianbao , Song Zhimin , Yang Chengtao , Li Bing , Ren Jiangang , Xiao Ming 
Published: September 2022

The permeability of coal is a key parameter affecting coal and gas outbursts and coal seam gas drainage. The permeability is clearly affected by geo-stress. In this study, the influence of the axial pressure on the permeability of the coal seam was studied using a self-developed true triaxial stress permeability experimental device to set fixed gas and confining pressures, and to change the magnitude of the axial pressure. The experimental results show a polynomial relationship between the axial pressure and the permeability of the coal seam. With an increase in axial pressure, the permeability initially decreased slightly and then increased gradually. When the axial pressure exceeded 30 MPa, the permeability of the coal seam sharply increased. This may be due to plastic deformation of the coal seam under a large axial pressure, resulting in new fractures and significantly improving the permeability of the coal seam. Using the COMSOL numerical simulation software, the effect of in situ stress on the coal seam gas drainage efficiency was calculated by comprehensively considering the adsorption/desorption, diffusion, and seepage of gas. The calculation results show that with an increase in the axial pressure, the gas drainage efficiency of the coal seam increases continuously. As the axial pressure increased from 5 to 30 MPa, the gas drainage efficiency increased to 2–3 times that of the original value.
Atlas of metabolism reveals palmitic acid results in mitochondrial dysfunction and cell apoptosis by inhibiting fatty acid β-oxidation in Sertoli cells
Authors: Xu Xiaoqin , Luo Dandan , Xuan Qiuhui , Lu Peng , Yu Chunxiao , Guan Qingbo 
Published: September 2022

In recent years, the impact of lipotoxicity on male fertility has received extensive attention, especially on Sertoli cells (SCs). In SCs, energy metabolism is important as disorders of energy metabolism result in infertility eventually. However, the underlying mechanism of lipotoxicity on energy metabolism in SCs remains unknown. Advances in high-throughput metabolomics and lipidomics measurement platforms provide powerful tools to gain insights into complex biological systems. Here, we aimed to explore the potential molecular mechanisms of palmitic acid (PA) regulating energy metabolism in SCs based on metabolomics and lipidomics. The results showed that glucose metabolism-related metabolites were not significantly changed, which suggested that PA treatment had little effect on glucose metabolism and may not influence the normal energy supply from SCs to germ cells. However, fatty acid β-oxidation was inhibited according to accumulation of medium- and long-chain acylcarnitines in cells. In addition, the pool of amino acids and the levels of most individual amino acids involved in the tricarboxylic acid (TCA) cycle were not changed after PA treatment in SCs. Moreover, PA treatment of SCs significantly altered the lipidome, including significant decreases in cardiolipin and glycolipids as well as remarkable increases in ceramide and lysophospholipids, which indicated that mitochondrial function was affected and apoptosis was triggered. The increased apoptosis rate of SCs was verified by elevated protein expression levels of Cleaved Caspase-3 and Bax as well as decreased Bcl-2 protein expression level. Together, these findings indicated that PA may result in mitochondrial dysfunction and increased apoptosis by inhibiting fatty acid β-oxidation of SCs.
Prevalence of nocturnal hypoglycemia in free-living conditions in adults with type 1 diabetes: What is the impact of daily physical activity?
Authors: Molveau Joséphine , Rabasa-Lhoret Rémi , Myette-Côté Étienne , Messier Virginie , Suppère Corinne , J. Potter Kathryn , Heyman Elsa , Tagougui Sémah 
Published: September 2022

ObjectiveStudies investigating strategies to limit the risk of nocturnal hypoglycemia associated with physical activity (PA) are scarce and have been conducted in standardized, controlled conditions in people with type 1 diabetes (T1D). This study sought to investigate the effect of daily PA level on nocturnal glucose management in free-living conditions while taking into consideration reported mitigation strategies to limit the risk of nocturnal hyoglycemia in people with T1D.MethodsData from 25 adults (10 males, 15 females, HbA1c: 7.6 ± 0.8%), 20-60 years old, living with T1D, were collected. One week of continuous glucose monitoring and PA (assessed using an accelerometer) were collected in free-living conditions. Nocturnal glucose values (midnight–6:00 am) following an active day “ACT” and a less active day “L-ACT” were analyzed to assess the time spent within the different glycemic target zones (&lt;3.9 mmol/L; 3.9 – 10.0 mmol/L and &gt;10.0 mmol/L) between conditions. Self-reported data about mitigation strategies applied to reduce the risk of nocturnal hypoglycemia was also analyzed.ResultsOnly 44% of participants reported applying a carbohydrate- or insulin-based strategy to limit the risk of nocturnal hypoglycemia on ACT day. Nocturnal hypoglycemia occurrences were comparable on ACT night versus on L-ACT night. Additional post-meal carbohydrate intake was higher on evenings following ACT (27.7 ± 15.6 g, ACT vs. 19.5 ± 11.0 g, L-ACT; P=0.045), but was frequently associated with an insulin bolus (70% of participants). Nocturnal hypoglycemia the night following ACT occurred mostly in people who administrated an additional insulin bolus before midnight (3 out of 5 participants with nocturnal hypoglycemia).ConclusionsAlthough people with T1D seem to be aware of the increased risk of nocturnal hypoglycemia associated with PA, the risk associated with additional insulin boluses may not be as clear. Most participants did not report using compensation strategies to reduce the risk of PA related late-onset hypoglycemia which may be because they did not consider habitual PA as something requiring treatment adjustments.
Design of a soft-contact triboelectric nanogenerator for vibrational energy collection and its output performance
Authors: Yan Jin , Mei Naerduo , Zhang Dapeng , Zhong Yinghao 
Published: September 2022

Finding renewable energy sources to lower carbon emissions has emerged as a challenge the world faces in the wake of global warming and energy crises. Vibration is a type of mechanical motion common in daily life, and one popular research topic in this regard is how to gather vibrational energy and transform it into electricity. Vibration energy can be collected using triboelectric nanogenerators whose working mechanism is based on contact electrification and electrostatic induction. The COMSOL software is used to simulate the relationship between the voltage across electrodes, transferred charge, and the electrode moving distance (V-Q-X) of triboelectric nanogenerator. Theoretical analysis of the simulation result is offered, along with a brief description of the simulation procedure. When wool is glued to the inner core aluminum foil, TENG’s output performance is significantly improved, with a maximum open-circuit voltage of 160 V. In addition, TENG’s output performance improves linearly as the vibration frequency and amplitude increase. Specifically, when the vibration frequency rises from 1 to 2.5 Hz, the open-circuit voltage rises from 43 to 100 V, the short-circuit current increases from 0.45 to 1.5 µA, and the peak transfer charge grows from 23 to 46 nC; when the vibration amplitude increases from 30 to 60 mm, the maximum open-circuit voltage increases from 50 to 110 V, the maximum short-circuit current increases from 0.3 to 1.5 µA, and the maximum charge transfer increases from 21 to 54 nC. Durability tests of TENG shows that the soft-contact TENG with wool adhesives is exceptionally durable, with decreased mechanical wear on the contact surface and extended service life. The present work is expected to provide some insight into the working mechanism of low-loss and high-performance TENGs and facilitate their wider adoption.
An eco-technoeconomic analysis of hydrogen production using solid oxide electrolysis cells that accounts for long-term degradation
Authors: Naeini Mina , Cotton James S. , Adams Thomas A. 
Published: September 2022

This paper presents an eco-technoeconomic analysis (eTEA) of hydrogen production via solid oxide electrolysis cells (SOECs) aimed at identifying the economically optimal size and operating trajectories for these cells. Notably, degradation effects were accounted by employing a data-driven degradation-based model previously developed by our group for the analysis of SOECs. This model enabled the identification of the optimal trajectories under which SOECs can be economically operated over extended periods of time, with reduced degradation rate. The findings indicated that the levelized cost of hydrogen (LCOH) produced by SOECs (ranging from 2.78 to 11.67 $/kg H2) is higher compared to gray hydrogen generated via steam methane reforming (SMR) (varying from 1.03 to 2.16 $ per kg H2), which is currently the dominant commercial process for large-scale hydrogen production. Additionally, SOECs generally had lower life cycle CO2 emissions per kilogram of produced hydrogen (from 1.62 to 3.6 kg CO2 per kg H2) compared to SMR (10.72–15.86 kg CO2 per kg H2). However, SOEC life cycle CO2 emissions are highly dependent on the CO2 emissions produced by its power source, as SOECs powered by high-CO2-emission sources can produce as much as 32.22 kg CO2 per kg H2. Finally, the findings of a sensitivity analysis indicated that the price of electricity has a greater influence on the LCOH than the capital cost.
Fine intervals are required when using point intercept transects to assess coral reef status
Authors: Kuo Chao-Yang , Tsai Cheng-Han , Huang Ya-Yi , Heng Wei Khang , Hsiao An-Tzi , Hsieh Hernyi Justin , Chen Chaolun Allen 
Published: September 2022

The Point Intercept Transect (PIT) method has commonly been used in recent decades for estimating the status of coral reef benthic communities. It is a simple method that is efficiently performed underwater, as benthic components are recorded only as presence or absence at specific interval points along transects. Therefore, PIT is also popular in citizen science activities such as Reef Check programs. Longer intervals are commonly associated with longer transects, yet sampling interval length can significantly influence benthic coverage calculations. Despite this, the relative accuracy of longer or shorter intervals related to transect length has not been tested for PIT. In this study, we tested the optimum intervals of PIT for several commonly used transect lengths using the bootstrap method on empirical data collected on tropical coral reefs and non-reefal coral communities. Our results recommend fine intervals of 10 cm or shorter, depending on the length of the transect, to increase the accuracy of estimating benthic community status on coral reefs. Permanent transects should also be considered in long-term monitoring programs to improve data quality.
The effect of “Fishery-PV Integration” on Penaeus monodon culture and research on the micro-ecological environment
Authors: Liao Minze , Long Xinxin , He Zihao , Zhao Jichen , Chen Xieyan , Zhu Dongwenjun , Sun Chengbo 
Published: September 2022

“Fishery-photovoltaic (PV) Integration” is a novel aquaculture model that provides enormous potential for aquaculture development. However, research on the aquaculture environment and organisms under the “Fishery-PV Integration” mode is presently sparse. This study investigated Penaeus monodon as a model, studying the growth rates of shrimp, water quality conditions, and the micro-ecological environment. After 105 days of rearing, P. monodon (initial weight of 0.006 ± 0.001 g) reached an average body weight of 11.69 ± 0.92 g. The water quality was stable (C(NH4+) ≤ 1.57 mg/L) during the experimental period. The 16S rRNA gene sequencing results showed that bacterial community structures were significantly distinct among water, effluent and intestinal environments, with a closer relationship between the microbiotas in effluent and water. The dominant phyla present in shrimp intestines, water, and effluent were Proteobacteria, Actinobacteriota, and Bacteroidota. Likewise, Ralstonia, Candidatus Aquiluna, and Vibrio were the dominant genus in the three groups. The relative abundance of Vibrio as a common opportunistic pathogen for shrimp was relatively low, which is beneficial to promote the healthy growth of shrimp. The function of the “Fishery-PV Integration” microbiota was investigated using metagenomic technology. Results showed that microorganisms played an essential role in regulating intestinal amino acids, carbohydrate, and energy metabolisms. Antibiotic resistance genes (ARGs) data indicate that tetH, QnrVC6 and tetX were dominated ARGs in the intestine. At the same time, the ARGs with the highest relative abundance in the water and effluent groups were MexL and adeF. Notably, only 123 ARGs were identified within the “Fishery-PV Integration” pond. This outcome is significantly lower than other studies, indicating that shrimp cultured in the “Fishery-PV Integration” pond had a higher level of food safety. The current study describes the characteristics of the microflora and ARGs distribution in the “Fishery-PV Integration” pond for the first time, providing fundamental information for formulating management strategies for the whole microflora to maintain the health of shrimp.
A new nomogram including total cerebral small vessel disease burden for individualized prediction of early-onset depression in patients with acute ischemic stroke
Authors: Zhou Lihua , Chen Licong , Ma Linqing , Diao Shanshan , Qin Yiren , Fang Qi , Li Tan 
Published: September 2022

ObjectivesThe present study was designed to evaluate the effects of total cerebral small vessel disease (CSVD) on early-onset depression after acute ischemic stroke (AIS), and to develop a new nomogram including total CSVD burden to predict early-onset post-stroke depression (PSD).MethodsWe continuously enrolled patients with AIS who were hospitalized at the First Affiliated Hospital of Soochow University between October 2017 and June 2019. All patients were assessed for depressive symptoms using the 17-item Hamilton Depression Scale (HAMD-17) at 14 ± 2 days after the onset of AIS. The diagnosis for depression was made according to the American Diagnostic and Statistical Manual of Mental Disorders Version 5 (DSM-5). The demographic and clinical data were collected including total CSVD burden. On the basis of a multivariate logistic model, the independent factors of early-onset PSD were identified and the predictive nomogram was generated. The performance of the nomogram was evaluated by Harrell's concordance index (C-index) and calibration plot.ResultsA total of 346 patients were enrolled. When contrasted to a 0 score of total CSVD burden, the score ≥2 (moderate to severe total CSVD burden) was an independent risk factor for early-onset PSD. Besides, gender, cognitive impairments, baseline Barthel Index (BI), and plasma fibrinogen were independently associated with early-onset PSD. The nomogram based on all these five independent risk factors was developed and validated with an Area Under Curve (AUC) of 0.780. In addition, the calibration plot revealed an adequate fit of the nomogram in predicting the risk of early-onset depression in patients with AIS.ConclusionsOur study found the total CSVD burden score of 2–4 points was an independent risk factor of early-onset PSD. The proposed nomogram based on total CSVD burden, gender, cognitive impairments, baseline BI, and plasma fibrinogen concentration gave rise to a more accurate and more comprehensive prediction for early-onset PSD.
The role of robotic surgery for the treatment of hilar cholangiocarcinoma: A systematic review
Authors: Brolese Alberto , Rigoni Marta , Pasquale Alessio , Viel Giovanni , Brolese Marco , Ciarleglio Francesco Antonio 
Published: September 2022

BackgroundThe role of robotic surgery (RS) for hilar cholangiocarcinoma (HC) is under investigation. Surgical resection is the only curative modality of treatment but extremely complex and high risk of morbidity and mortality may occur. The aim of this study is to perform a systematic review of perioperative and oncological outcomes of RS for HC, across a comprehensive range of outcomes reported in recent literature.Materials and MethodsPRISMA checklist was used as a basis for writing the systematic review and studies’ selection. Literature documenting RS for HC was analyzed by searching PubMed and Cochrane Library from 2009 to May 2022. The search terms, either independently or in combination, were used according to PICOT framework. The target population are patients treated with robotic surgical approach for HC.Results12 studies with 109 patients were included after screening process. The Bismuth classification in all series except one was: 21 type I, 7 type II, 12 type IIIa, 26 type IIIb and 4 type IV. Mean operative time for a total of 21 patients was 644 minutes. Other two case series reported a median operative time of 375 with a console time of 276 minutes. Mean blood loss for case reports and two case series was 662 milliliters. Blood transfusion rate for all operation was 33.3%. Overall Conversion rate was 2.8%. Pooled post operative morbidity and mortality was 39.8% and 1.8% respectively. Mean LOS for case reports and one case series for a total of 17 patients was 16 days. R0 resection rate for the 11 papers was 74.3%. Seven out of 12 studies reported on the oncological follow up: median observation time ranged from 5 to 60 months, recurrence rate was 52.6% (range 0-90%) reported only in 19 patients (10/19).ConclusionsRS for HC was feasible and safe. However, although this systematic review could not be conclusive in most of the analyzed items, RS for the treatment of HC could represent the best tool for a future meticulous and precision surgery. The review’s results certainly indicate that further research in urgently is required on this field.
Metanephrine and normetanephrine associated with subclinical myocardial injuries in pheochromocytoma and paraganglioma
Authors: Yu Yang , Chen Chuyun , Han Wencong , Zhang Yan , Zhang Zheng , Yang Ying 
Published: September 2022

ObjectiveTo analyze the correlation between metanephrine and normetanephrines (MNs) and subclinical myocardial injuries (SMI) diagnosed by low left ventricular global longitudinal strain (LV GLS) in patients with pheochromocytoma and paraganglioma (PPGL).MethodsSeventy-six patients who underwent surgery for pheochromocytoma or paraganglioma from September 2017 to April 2022 were examined. All the patients enrolled had normal left ventricular ejection fraction (LVEF) and myocardial injury biomarkers including cardiac troponin I and B-natriuretic peptide. Univariate analysis and multivariate analysis were performed to evaluate the association of MNs and subclinical myocardial injury (SMI)(defined as LV GLS&lt;18).ResultsLV GLS of 13(17.11%) PPGL patients was less than 18. The percentage of patients with elevation of single hormone (metanephrine, normetanephrine, 3-methoxytyramine) or any one of MNs was not significantly correlated with SMI (P=0.987, 0.666, 0.128 and 0.918, respectively). All MNs elevation was associated with SMI (OR: 11.27; 95% CI, 0.94—135.24; P= 0.056). After adjusting for age, All MNs elevation was significantly correlated with SMI (OR: 16.54; 95% CI, 1.22—223.62; P= 0.035).ConclusionMNs might be an important factor influencing myocardial function. All MNs elevation might indicate SMI. If all MNs elevated, LV GLS measurement was recommended for PPGL patients to detect SMI in the absence of decrease LVEF or other heart disease in clinical practice.
Hematopoietic stem cell transplantation from HLA-matched sibling donors in children with acute lymphoblastic leukemia: A report from the Children’s Cancer Hospital Egypt
Authors: Hammad Mahmoud , Hafez Hanafy , Sidhom Iman , Yassin Dina , Salem Sherine , Alsheshtawi Khaled , Hamdy Nayera , Elsharkawy Nahla , Elhaddad Alaa 
Published: September 2022

IntroductionAllogeneic hematopoietic stem cell transplantation (HSCT) is widely used for high-risk acute lymphoblastic leukemia (ALL) patients in their first complete remission (CR1), and for relapsed patients in second complete remission (CR2).Patients and methodsWe retrospectively analyzed data for 67 children with ALL, from a cancer center in a low/middle income country, who had undergone HSCT from human leukocyte antigen (HLA)-matched sibling donors (MSDs) using myeloablative conditioning (MAC) regimens, between 2007 and 2020, describing the survival outcome and relapse probability after achieving CR1 and CR2 and determining outcome differences in relation to indications for HSCT in patients transplanted in CR1. All patients had achieved a negative minimal residual disease prior to transplant (&lt;0.01%).ResultsForty-six patients (68.7%) were in CR1; 25 had adverse cytogenetics, including 18 patients with Philadelphia chromosome-positive ALL (Ph-positive ALL), and 21 had poor induction response. The 5-year overall survival (OS), event-free survival (EFS) and cumulative incidence of relapse (CIR) for the whole cohort were 56.1% (95% CI, 42.8%-69.4%), 49% (95% CI, 35.7%-62.3%) and 33.5% (95% CI, 21.7%-45.8%), respectively with better EFS and CIR for CR1 transplants compared to CR2 transplants (P=0.02 and P=0.03, respectively). Patients with Ph-positive ALL had better 5-year OS, EFS and non-relapse mortality (NRM) compared with other CR1 transplants (P=0.015, P=0.009 and P=0.028, respectively).ConclusionHematopoietic stem cell transplantation from MSD for ALL in CR1 group had superior outcomes compared to CR2 group and was apparently a curable option for Ph-positive ALL without an increased risk of non-relapse mortality. Poorer survival rates and higher relapse probabilities were associated with HSCT conducted to patients who had a poor response to induction therapy or suffered a relapse.
Effect of long-term cannabidiol on learning and anxiety in a female Alzheimer’s disease mouse model
Authors: Chesworth Rose , Cheng David , Staub Chloe , Karl Tim 
Published: September 2022

Cannabidiol is a promising potential therapeutic for neurodegenerative diseases, including Alzheimer’s disease (AD). Our laboratory has shown that oral CBD treatment prevents cognitive impairment in a male genetic mouse model of AD, the amyloid precursor protein 1 x presenilin 1 hemizygous (APPxPS1) mouse. However, as sex differences are evident in clinical populations and in AD mouse models, we tested the preventive potential of CBD therapy in female APPxPS1 mice. In this study, 2.5-month-old female wildtype-like (WT) and APPxPS1 mice were fed 20 mg/kg CBD or a vehicle via gel pellets daily for 8 months and tested at 10.5 months in behavioural paradigms relevant to cognition (fear conditioning, FC; cheeseboard, CB; and novel object recognition test, NORT) and anxiety-like behaviours (elevated plus maze, EPM). In the CB, CBD reduced latencies to find a food reward in APPxPS1 mice, compared to vehicle-treated APPxPS1 controls, and this treatment effect was not evident in WT mice. In addition, CBD also increased speed early in the acquisition of the CB task in APPxPS1 mice. In the EPM, CBD increased locomotion in APPxPS1 mice but not in WT mice, with no effects of CBD on anxiety-like behaviour. CBD had limited effects on the expression of fear memory. These results indicate preventive CBD treatment can have a moderate spatial learning-enhancing effect in a female amyloid-β-based AD mouse model. This suggests CBD may have some preventive therapeutic potential in female familial AD patients.