bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analisa Sumber-sumber dan Penggunaan Modal Kerja PT Gudang Garam Tbk dan Entitas Anak
Authors: Widodo Eko 
Published: August 2022

Jenis penelitian ini adalah penelitian deskriptif yang bertujuan untuk menganalisis darimana sumber-sumber modal kerja PT Gudang Garam Tbk dan Entitas Anak diperoleh dan digunakan untuk apa modal kerja yang telah diperoleh pada periode usaha tahun 2020.
Penelitian ini juga bertujuan untuk mengetahui kebijakan yang telah diambil oleh PT Gudang Garam Tbk dan Entitas Anak sudah tepat atau keliru, dalam hal penggunaan modal kerja yang telah dilakukan dari sumber-sumber modal kerja yang telah diperoleh apabila ditinjau dari prinsip pembelanjaan konservatif.
Hasil analisis sumber-sumber dan penggunaan modal kerja PT Gudang Garam Tbk dan Entitas Anak menunjukkan bahwa sumber-sumber modal kerja PT Gudang Garam Tbk dan Entitas Anak dalam periode usaha tahun 2020 berasal dari: saldo laba belum dicadangkan, liabilitas imbalan pasca kerja, depresiasi aset tetap dan yang lainnya, sedangkan penggunaan modal kerjanya untuk: pengadaan aset tetap, mengangsur pinjaman jangka panjang, menambah modal kerja dan yang lainnya.
Menurut prinsip pembelanjaan konservatif bahwa kebijakan yang telah dilakukan oleh manajemen PT Gudang Garam Tbk dan Entitas Anak dalam tahun 2020 menggunakan sumber modal kerjanya yang bersifat permanen (jangka panjang) yaitu laba yang belum dicadangkan, depresiasi aset tetap dan liabilitas imbalan pasca kerja untuk membelanjai investasi yang bersifat jangka panjang yaitu pengadaan aset tetap, menambah modal kerja dan yang lainnya adalah sudah tepat dari aspek likuiditas.
EFEK MUTILASI GIGI 36 DAN 46 TERHADAP DIMENSI HORISONTAL BAWAH PADA MALOKLUSI KLAS I ANGLE
Authors: Maulana Paulus 
Published: August 2022

Latar belakang : Gigi 36 dan 46 berperan untuk mempertahankan oklusi. Kehilangan gigi 36 dan 46 berakibat perubahan kedudukan gigi tetangga dan antagonis, perubahan spontan tumpang gigit, jarak gigit dan inklinasi insisif. Molar kedua bergerak ke mesial, premolar kedua, premolar pertama dan kaninus bergeser ke distal. Mutilasi gigi merupakan kehilangan gigi yang terjadi lebih dari 5 tahun. Kehilangan gigi 36 dan 46 selama lebih dari 5 tahun secara hipotesis akan menyebabkan perubahan dimensi vertikal, dimensi horisontal wajah dan rahang gigi. Dampak terhadap dimensi horisontal dipilih di penelitian ini. Metode penelitian: Jenis penelitian observasional analitik. Populasi penelitian ini penderita maloklusi kelas I Angle di klinik Dent Smile tahun 2011 – 2015. Sampel adalah total sampel penderita mutilasi gigi 36 dan 46 dan didapatkan 22. Variabel dimensi horisontal diwakili sudut NAP, ANB, INB, dan IGoMe. Data diuji tes Kolmogorov Sminov untuk melihat distribusi data dan didapatkan nilai p 0,05, dilanjutkan uji beda (Independent t dan Mann Whietney) untuk melihat perbedaan antar kelompok. Hasil penelitian: Hasil uji perbedaan kelompok non mutilasi dan mutilasi didapatkan nilai p pada sudut NAP, ANB, INB, IGoMe 0,05. Sudut NAP, ANB, INA, INB, IGoMe disimpulkan ada perbedaan bermakna antara kelompok non mutilasi dan mutilasi. Kesimpulan: Terjadi perubahan anteroposterior muka disebabkan ada perbedaan bermakna sudut NAP dan ANB pada kelompok mutilasi dan non mutilasi. Inklinasi insisif rahang bawah lebih retrusif dikarenakan berkurangnya sudut I-GoMe dan I-NB pada kelompok mutilasi dan non mutilasi. Perubahan ini sebagai akibat dari mutilasi gigi 36 dan 46.
Influência do Processo Extrativo, Solvente e Tamanho da Partícula do Material Vegetal no Teor de Sólidos Totais da Solução Extrativa da Schinus terebinthifolius Raddi
Authors: Moura T. F. A. L. , Vasconcelos E. A. F. , Barbosa R. M. , Medeiros M. G. F. 
Published: August 2022

O objetivo deste estudo foi padronizar as condições para obtenção da solução extrativa da Schinus terebinthifolius Raddi. A solução extrativa foi selecionada através do delineamento fatorial do tipo 23 considerando o método de extração (maceração e percolação), líquido extrator (etanol 700 GL e água) e a granulometria (Fração I: partículas totais e Fração II: 710 μm ≥ φ ≥ 210 μm) na proporção planta solvente de 1:10 (m/v), utilizando o resíduo seco como parâmetro de avaliação. Os resultados foram submetidos à análise de variância para verificar a origem dos efeitos e/ou interações. Os resultados comprovaram a importância do método de extração, do solvente e da granulometria do material vegetal no processo extrativo, sendo a granulométrica o fator mais importante na eficiência do processo independente do método.
KONSENTRASI PUPUK ORGANIK CAIR TERHADAP DUA VARIETAS TANAMAN SEMANGKA (Citrullus vulgaris Schard)
Authors: Pratama Anggi Wahyu , Ratna Nurhayati Dewi , Siswadi Siswadi 
Published: August 2022

Penelitian tentang kajian Konsentrasi pupuk organik cair terhadap dua varietas tanaman semangka (Citrullus vulgaris Schard) dilaksanakan pada bulan juni– agustus 2021. dilaksankan di Research Center Jaya Wijaya Fakultas Pertanian Universitas Slamet Riyadi Surakarta, yang berlokasi di Kelurahan joglo, Kecamatan Banjarsari, Kota Surakarta, Jawa Tengah 57136. Penelitian ini bertujuan untuk mengkaji Konsentrasi pupuk organik cair terhadap dua varietas tanaman semangka (Citrullus vulgaris Schard). Penelitian ini menggunakan metode Rancangan Acak Kelompok Lengkap (RAKL) yang di susun secara Faktorial, terdiri dari dua factor, yaitu (1) macam varietas semangka yang terdiri dari: varietas Punggawa F1(V1), Varietas Baginda F1(V2). (2) konsentrasi pupuk organik cair yang terdiri dari: tanpa pupuk organik cair (P0), Konsentrasi 20 ml/liter air (P1), Konsentrasi 40 ml/liter air (P2), Konsentrasi 60 ml/liter air (P3). Dari kedua perlakuan tersebut diperoleh 8 kombinasi dan setiap kombinasi diulang 4 kali, sehingga terdapat 32 kombinasi. Analisi data yang digunakan untuk mengetahui ada tidaknya pengaruh perlakuan tersebut, digunakan analisis ragam, dilanjutkan dengan UjiiDuncan’s Multiple Range Testi(DMRT)ipada taraf 5%. Hasil penelitian menunjukkan bahwa pemberian konsentrasi pupuk organik cair pada tanaman semangka varietas Punggawa F1 tidak berpengaruh nyata terhadap Panjang tanaman, waktu muncul bunga, berat brangkasan basah, berat brangkasan kering, dan Panjang buah, tetapi berpengaruh terhadap warna daun dan lingkar buah, hasil tertinggi yaitu pada perlakuan konsentrasi 60 ml/liter air (P3) mampu menghasikan warna daun 3,92, lingkar buah 39,75 cm, dan perlakuan konsentrasi 20 ml/liter air (P2) mampu menghasilkan berat buah 1132,58 gram, sedangkan varietas Baginda F1 tidak berpengaruh nyata terhadap Panjang tanaman, waktu muncul bunga, berat brangkasan basah, berat brangkasan kering, dan Panjang buah, tetapi berpengaruh terhadap warna daun dan berat buah, lingkar buah, hasil tertinggi yaitu pada perlakuan konsentrasi 60 ml/liter air (P3) mampu menghasikan warna daun 4,00, lingkar buah 39,75 cm, dan berat buah 1179,42 gram.
Las ciudades Patrimonio Mundial de España. Gestión, buenas Prácticas y nuevas necesidades
Authors: García Viana Diego , Jiménez López David 
Published: August 2022

Desde que vio la luz la Convención de Patrimonio Mundial Cultural y Natural hace 50 años, España acumula 49 bienes incluidos en la Lista de Patrimonio Mundial, entre manifestaciones materiales y añadiendo las inmateriales, hecho que resalta la extraordinaria riqueza y diversidad del conjunto patrimonial cultural de nuestros pueblos y ciudades. Algunos de estos bienes reconocidos y declarados son centros históricos de ciudades esparcidos por toda la geografía española.
Algunos de estos centros históricos fueron declarados e incluidos en la Lista en el pasado siglo y la gestión ha ido evolucionando, y los retos que se planteaban en aquel entonces, hoy día se han visto superados, o ha habido la urgencia de adoptar unos nuevos La evolución de la gestión, de las buenas prácticas, en estas ciudades ha ido desarrollándose, a la vez que evolucionaba la Convención. Por ello, algunas de estas ciudades y sus centros históricos, han desarrollado nuevas estrategias, han cambiado su gestión, y han ido adaptándose a las directrices de la UNESCO en pos de afrontar los retos a futuro planteados.
Classical and Point-of-Care tests in severe hemorrhage management
Authors: Simioni Paolo 
Published: August 2022

Hemorrhage is defined as an acute loss of blood from the cardiovascular system. The hemostatic cascade (comprising the vasculature, coagulation factors, the fibrinolytic and the platelet systems) is the physiological mechanism meant to control this event. Coagulation assessment is fundamental in the monitoring and treatment of hemorrhage. Over the years several classical laboratory-based diagnostic tests have been developed for the management of severe hemorrhage, however their main downside is the time necessary to obtain a result, which can be significant (between 40 minutes and an hour) and therefore not be entirely representative of a fastchanging clinical picture. Based on this need of faster results, Point-of-Care tests have been developed and implemented, since they can represent a diagnostic tool that allows a reduction of the time interval before appropriate intervention. They rely on instruments able to determine blood clot formation in whole blood samples upon activation of coagulation with specific reagents, and activation of platelets upon exposure to different drugs. The present review proposes an overview of both the available Point-of-Care tests such as Thrombelastography, for the assessment of blood clot formation, Impedance Aggregometry, for the function of platelets, and those still under improvement or missing entirely.
Sepsis-induced coagulopathy and disseminated intravascular coagulation
Authors: Giarratano Antonino 
Published: August 2022

The definition of sepsis is usually associated to the innate immune system while instead, it is also connected to a response of the coagulation system, given that in septic patients thrombohemorrhagic events occur. The activation of the immune response and the recruitment of the coagulation system aim at the compartmentalization in the vascular stream of the response to the microorganism to avoid its spreading. This mechanism, as a side effect, exposes the organism to a variety of “dysregulations”. Disseminated Intravascular Coagulation (DIC) can present itself in septic patients with one of three different phenotypes: pro-coagulant, fibrinolytic and hemorrhagic. Associated to DIC, as it can be considered its predecessor, is Sepsis-Induced Coagulopathy (SIC) a prior, faster-evolving condition. International institutions have developed a scoring system to distinguish SIC from overt-DIC, which has the distinctive characteristics of a reduced platelet count in the initial stages and a higher INR value. Being a rapidly evolving condition SIC needs to be quickly diagnosed and treated; to this day no concrete recommendations exist regarding a therapeutic approach. Unfractionated heparin, antithrombin III, thrombomodulin and recombinant protein C have shown limited, or even non-existing, effects in SIC treatment, while the use of thromboelastography and thromboelastometry has represented a progress in the testing of coagulation-hemorrhagic conditions. The procedure to be followed is, besides microcirculation resuscitation, a prompt intervention with antibiotic treatment and the execution of a de-escalation protocol. Further studies are still necessary to define the most effective treatment for these conditions.
Predictores histopatológicos de respuesta a tratamiento en pacientes con cáncer de mama receptores hormonales positivos her2 negativo
Authors: Cabrera Mañay Cristina Elisa , Rivera Rivera Tannia Mariella 
Published: August 2022

Introducción: Una de cada 18 mujeres desarrolla a lo largo de su vida cáncer de mama, siendo esta la principal causa de muerte por cáncer en mujeres. El propósito del presente estudio fue establecer el valor predictivo de los factores histopatológicos presentes en tumores malignos de mama con receptores hormonales positivos Her2 negativo de un grupo de pacientes en un centro de referencia oncológico.
Metodología: Este estudio longitudinal se realizó en el Instituto Oncológico Nacional “Dr Juan Tanca Marengo”, de Guayaquil - Ecuador. El período de inclusión del 2007 al 2009 con período de observación hasta diciembre del 2020. Con una muestra no probabilística, se incluyeron mujeres con cáncer de mama, hormonal positivo Her2 Neu negativo, que hayan recibido tratamiento adyuvante durante un periodo de seguimiento. Se midieron variables demográficas, clínicas, relacionadas al tumor, clasificación TNM y sobrevida. Se realiza un análisis univariado descriptivo de la muestra, un análisis bivariado, comparando el grupo de pacientes fallecidas con el grupo de pacientes vivas; un análisis de correlación entre variables en escala; un análisis de supervivencia y finalmente se presenta una regresión COX para predecir la supervivencia en base a las variables.
Resultados: Ingresaron al estudio 105 pacientes, de 54.1 ± 11.4 años. 58.1% de casos en etapa temprana y 41.9% en etapa localmente avanzada. La sobrevida global (SG) fue de 67.6% a 14 años y la sobrevida libre de progresión (SLP) del 59.05%. La terapia de bloqueo hormonal se asoció con la SLP (R=0.544, P<0.01) y con SG (R=0.399, P<0.05). El compromiso ganglionar en estadio N0 tuvo una SLP de 11.9 ± 0.4 años, en estadio N3 fue de 6.8 ± 1.6 años (P<0.01). El modelo de regresión de Cox para predecir el tiempo de vida libre de progresión o enfermedad fue estadísticamente significativo con la terapia de bloqueo hormonal (R2=0.607, P<0.001).
Conclusión: La terapia de bloqueo hormonal mantenida por más de 5 años tiene un impacto positivo en la supervivencia de las pacientes con cáncer de mama hormonal positivo Her2 Neu negativo.
Early-onset preeclampsia is characterised by an increased vascular tone in internal jugular veins
Authors: Dierickx Inge , Kremer Cécile , Bruckers Liesbeth , Gyselaers Wilfried 
Published: August 2022

PurposeThis study aimed to investigate Doppler characteristics of maternal internal jugular veins in uncomplicated pregnancies vs. those affected by hypertensive disorders.Materials and methodsVenous pulse transit time and venous impedance index were measured at three different locations (right proximal, right distal, left proximal) of internal jugular veins according to a standardised combined Doppler-Electrocardiogram protocol in five different groups of pregnant women: uncomplicated pregnancy, early-onset preeclampsia, late-onset preeclampsia, gestational hypertension, and normotensive pregnancies with a small for gestational age foetus. Values of both parameters of the latter four groups were plotted against the reference range of uncomplicated pregnancies at corresponding gestation. Linear mixed models with random intercept were used to investigate gestational changes in venous pulse transit time and venous impedance index at the three internal jugular vein locations within and between the different groups.ResultsA total of 127 women were included: 41 had uncomplicated pregnancies, 13 had early-onset preeclampsia, 25 had late-onset preeclampsia, 22 had gestational hypertension, and 26 had normotensive pregnancies with a small for gestational age foetus. Venous pulse transit time values were lower than uncomplicated pregnancy (p ≤ 0.001) at all three locations in the third trimester of early-onset preeclampsia.ConclusionContrary to late-onset preeclampsia and gestational hypertension, early-onset preeclampsia is characterised by a lower venous pulse transit time at internal jugular veins compared to uncomplicated pregnancy, suggesting increased venous vascular tone.
Case Report: Heterozygous Germline Variant in EIF6 Additional to Biallelic SBDS Pathogenic Variants in a Patient With Ribosomopathy Shwachman–Diamond Syndrome
Authors: Taha Ibrahim , Foroni Selena , Valli Roberto , Frattini Annalisa , Roccia Pamela , Porta Giovanni , Zecca Marco , Bergami Elena , Cipolli Marco , Pasquali Francesco , Danesino Cesare , Scotti Claudia , Minelli Antonella 
Published: August 2022

Background: Shwachman–Diamond syndrome (SDS) is a rare autosomal recessive ribosomopathy mainly characterized by exocrine pancreatic insufficiency, skeletal alterations, neutropenia, and a relevant risk of hematological transformation. At least 90% of SDS patients have pathogenic variants in SBDS, the first gene associated with the disease with very low allelic heterogeneity; three variants, derived from events of genetic conversion between SBDS and its pseudogene, SBDSP1, provided the alleles observed in about 62% of SDS patients.Methods: We performed a reanalysis of the available WES files of a group of SDS patients with biallelic SBDS pathogenic variants, studying the results by next bioinformatic and protein structural analysis. Parallelly, careful clinical attention was given to the patient focused in this study.Results: We found and confirmed in one SDS patient a germline heterozygous missense variant (c.100T&gt;C; p.Phe34Leu) in the EIF6 gene. This variant, inherited from his mother, has a very low frequency, and it is predicted as pathogenic, according to several in silico prediction tools. The protein structural analysis also envisages the variant could reduce the binding to the nascent 60S ribosomal.Conclusion: This study focused on the hypothesis that the EIF6 germline variant mimics the effect of somatic deletions of chromosome 20, always including the locus of this gene, and similarly may rescue the ribosomal stress and ribosomal dysfunction due to SBDS mutations. It is likely that this rescue may contribute to the stable and not severe hematological status of the proband, but a definite answer on the role of this EIF6 variant can be obtained only by adding a functional layer of evidence. In the future, these results are likely to be useful for selected cases in personalized medicine and therapy.
Role of teledermatology in the management of dermatological diseases among marine workers: A cross-sectional study comparing general practitioners and dermatological diagnoses
Authors: Di Canio Marzio , Burzi Lorenza , Ribero Simone , Amenta Francesco , Quaglino Pietro 
Published: August 2022

BackgroundDiagnosis and treatment of skin disease in sea workers is an unmet need. The purpose of this study is to highlight how remote management of dermatological conditions appears inadequate in this scenario.ObjectiveThis study aimed to identify the best epidemiology for seafarers' diseases and analyze the adequacy of medical assistance in the diagnosis of dermatological maritime diseases.Material and methodsA total of 420 cases of requests for dermatological diseases received by the Telemedical Maritime Assistance Service of the International Medical Radio Center (C.I.R.M.). in a referral year were included in this cross-sectional study. All pictures of cutaneous lesions had been submitted to both C.I.R.M. doctors and an expert dermatologist who provided their diagnosis.ResultsThe most frequent diagnosis in both groups was infectious or inflammatory skin diseases. The main differences are represented by the amount of “unclassified dermatitis” or descriptive diagnosis, such as “cutaneous eruption” which were the most frequent diagnosis of C.I.R.M. doctors (p &lt; 0.05 and p &gt; 0.0001). In these cases, Cohen's K was &lt;0.5 consistent with low concordance between dermatologic diagnosis and C.I.R.M. diagnosis.Conclusion and relevanceOur study emphasizes the magnitude of dermatological diseases in the maritime sector, although often underestimated, and highlights the difficulty in their diagnosis for doctors on call that need more training on specific dermatological issues.
CalliSpheres® microsphere transarterial chemoembolization combined with 125I brachytherapy for patients with non–small‐cell lung cancer liver metastases
Authors: Zhao Guangsheng , Liu Song , Liu Ying , Li Xiang , Yu Guangji , Zhang Yuewei , Bian Jie , Wu Jianlin , Zhou Jun , Gao Fei 
Published: August 2022

ObjectivePoor prognosis and limited treatments of liver metastases from non–small‐cell lung cancer (NSCLC) after radical surgery are critical issues. The current study aimed to evaluate the efficacy and safety of CalliSpheres® microsphere transarterial chemoembolization (CSM-TACE) plus 125I brachytherapy in these patients.MethodsA total of 23 patients with liver metastases from NSCLC after radical surgery were included. All patients received CSM-TACE 1–3 times, then 125I brachytherapy was carried out following the last CSM-TACE. Complete response (CR), objective response rate (ORR), disease control rate (DCR), survival, and adverse events were evaluated.ResultsCR, ORR and DCR were 43.5%, 87.0%, and 100%, respectively, at three months; furthermore, they were 78.3%, 100%, and 100% accordingly at six months. Moreover, most European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-Core 30 (QLQ-C30) subscales of functions (including physical and emotional function) and symptoms (including pain, nausea, and vomiting) were generally improved at three months (all P &lt; 0.05). Furthermore, median progression-free survival (PFS) was 14.0 [95% confidence interval (CI): 10.4–17.6] months, with a 1-year PFS rate of 62.9%, but the 2-year PFS rate was not reached. Moreover, the median overall survival (OS) was 22.0 (95% CI: 16.8–27.2) months, with a 1-year OS rate of 91.3% and a 2-year OS rate of 43.5%. Additionally, the main adverse events included fever (100%), pain (65.2%), liver function impairment (65.2%), fatigue (56.5%), and nausea and vomiting (52.2%), which were all categorized as grade 1–2.ConclusionCSM-TACE plus 125I brachytherapy is effective and safe in patients with liver metastases from NSCLC after radical surgery, providing a potentially optimal option in these patients.
Subcutaneous soft tissue metastases from esophageal squamous cell carcinoma with neuroendocrine differentiation: Case report and literature review
Authors: Geng Xiaotao , Liu Jie , Sun Huimin , Song Zhenguo , Qin Shaoyong , Li Yang , Zhang Yanan , Hao Furong , Cai Yuanyuan 
Published: August 2022

BackgroundEsophageal squamous cell carcinoma is the predominant subtype of esophageal cancer in China and so differs from presentations in Western countries. Common metastatic locations of esophageal cancer include the liver, lung, bone, and brain. In contrast, metastases in subcutaneous soft tissue are exceedingly rare.Case presentationWe present the experience of a 57-year-old man with a complaint of hand and leg dysfunction on the right side. He had a past medical history of esophageal squamous cell carcinoma. Further imaging workup revealed a solitary brain metastasis, thickening of the esophageal wall, swollen lymph nodes in the mediastinum, and right adrenal gland metastasis. Gamma knife radiosurgery of the brain metastasis and intensity-modulated radiotherapy of the esophagus and lymph nodes were administered. After 1.5 months, he was admitted to our hospital again, and nodules were identified in the anterior abdominal wall and left posterior chest wall. Ultrasound, CT, and radical excision of the abdominal wall mass were undertaken and revealed metastatic squamous cell carcinoma with neuroendocrine differentiation. We administered immunotherapy followed by targeted therapy. A PET/CT scan was performed to identify other organ metastases; the scan revealed multiple areas of fluorodeoxyglucose uptake and foci in the esophagus, lung, liver, bone, and right adrenal gland; and in various lymph nodes. In addition, an intensely hypermetabolic lesion was localized in the left posterior thorax.ConclusionThis case highlights the diagnosis and treatment of uncommon metastases of esophageal squamous cell carcinoma. We hope that our clinical experience provides insights into these uncommon metastases.