bluuebunny/crossref_metadata_2025_split huggingface dataset:
Implementation of new segments in small- and medium-sized enterprises (SMEs)
Authors: Clarke Ann Højbjerg , Freytag Per Vagn 
Published: June 2022

Purpose
Successful segmentation and implementation are crucial for firms. This paper aims to focus on what areas small- and medium-sized enterprises (SMEs) consider when implementing new target segments in the organization. If firms do not understand the potential complexity and plan for implementation, they risk overlooking important areas that cause organizational resistance and failure in the market.

Design/methodology/approach
This paper builds on a literature study and five SME case studies based on 44 interviews and 10 intervention workshops.

Findings
The authors identify key areas of change that SMEs consider when planning to implement segments in the organization, including marketing strategy and plans, organizational aspects and implementation processes. Organization changes and sales plays are key considerations among SME managers. The authors further identify four categories characterized by different degrees of marketing and organizational changes that SMEs face when implementing new target segments, reflecting SMEs former choices.

Research limitations/implications
This research is based on interviews and workshops that bring managers into a situation where they can evaluate needed changes to implement segments. The managers can express the complexity and the effect of the implementation.

Practical implications
This paper presents considerations and insights derived from SMEs and discusses how firms can be better equipped to implement new segments.

Originality/value
This paper offers new insights and directions for segmentation literature, focusing on implementation and proposing how to advance the segmentation literature.
How entrepreneurs' dual narcissism affects new venture growth: the roles of personal initiative and learning from entrepreneurial failure
Authors: Wang Hongxin , Zheng Chundong , Wu Wenqing , Sui Fanhui 
Published: June 2022

PurposeBased on a personality-behavior-outcome framework, this study analyzes how entrepreneurs' dual narcissism (i.e. narcissistic admiration and rivalry) affects new venture growth (NVG) through learning from entrepreneurial failure (LFEF) and discusses the moderating effect of personal initiative on the relationship between dual narcissism and LFEF.Design/methodology/approachA total of 294 entrepreneurs from different cities and industries in China were selected as the research sample. The mediation effect was examined using the PROCESS macro, and the moderation effect was tested via hierarchical regression analysis.FindingsThis study found that narcissistic admiration positively affected NVG, while narcissistic rivalry had the opposite effect. LFEF mediated the relationships between narcissistic admiration/rivalry and NVG. In addition, the effects of narcissistic admiration and rivalry on LFEF were moderated by personal initiative.Practical implicationsThe findings suggest that entrepreneurs with narcissistic rivalry should deliberately regulate their cognition of failure and strengthen their learning from failure. Moreover, entrepreneurship education mentors should emphasize cultivating and guiding entrepreneurs' personal initiative in the context of frustration education. In addition, venture capitalists can consider incorporating the personality traits (i.e. dual narcissism and personal initiative) of entrepreneurs into the investment decision-making index system.Originality/valueThis study advances the relationship between narcissism and performance through the perspective of dual narcissism and provides a learning theory perspective for analyzing the narcissism–performance relationship. Moreover, by exploring the moderating role of personal initiative, this study enriches the understanding of the conditional factor that affects the ability to learn from failure.
Mechanical properties assessment of a 3D printed composite under torsional and perpendicular stress
Authors: Lovo João Fiore Parreira , Gerlin Neto Vicente , Piedade Lucas Pereira , Massa Renan Cesar , Pintão Carlos Alberto , Foschini Cesar Renato , Fortulan Carlos Alberto 
Published: June 2022

Purpose
This paper aims to evaluate the resin infiltration influence on the mechanical properties of components 3D printed by the material extrusion-based additive manufacturing (AM), also known as fused deposition modeling and commonly uses the acrylonitrile butadiene styrene (ABS) as depositing material. Improvements in their mechanical properties are desirable due failure resulting from the extrusion process. In this way, resin infiltration is considered a candidate solution to enhance 3D printed components’ strength.

Design/methodology/approach
The mechanical properties of AM samples produced with and without the resin infiltration were assessed under torsion, tensile and flexural stresses. Torsional tests are rarely found applied for this case, an alternative torsion test developed by one of the authors was used. The torsion modulus (G) is obtained without the Poisson’s ratio, which is usually unknown for recently made composites. Scanning electron microscopy was also done to verify the resin infiltration on the samples.

Findings
Results demonstrated that the resin infiltration on ABS can improve the mechanical properties of samples compared to non-infiltrated. The tensile and bending strength increased more than 6%. Both Young’s and torsion modulus also presented a significant increase. The samples did not present any considerable change in their weight property.

Originality/value
This paper discusses on resin infiltration on print ABS, as to produce a composite material, enhancing ABS properties without gaining weight. This paper also used the torsion modulus instead of the common approach of bringing only tensile and flexure strength.
Intention to stay and happiness: a moderated mediation model of work engagement and hope
Authors: Bellamkonda Neha , Pattusamy Murugan 
Published: June 2022

PurposeDrawing from the self-determination theory (SDT) model of work motivation (Gagné and Deci, 2005), the paper aims to examine the relationship between employee intention to stay and happiness through work engagement and analyses how hope acts as a boundary condition in this relationship.Design/methodology/approachIn this study a survey was conducted among the individuals working in the Information Technology (IT) and Information Technology Enable Services (ITeS) sector across India. The data were assessed through PROCESS v.3.3 macros in Statistical Package for Social Sciences (SPSS).FindingsThe moderated mediation results from 256 responses reveal that the intention to stay is positively related to happiness and that this relationship is mediated by work engagement. The indirect effect of intention to stay on happiness is seen to be strengthened by hope, thus substantiating the moderated mediation hypothesis.Practical implicationsThe empirical insights will be valuable for managers and organisations in the IT/ITES sectors around the globe. Happy employees are productive employees, and practitioners should focus on creating a positive environment.Originality/valueThis study aids in understanding the outcomes of intention to stay and moderating the role of hope between intention to stay and work engagement. It highlights how the positive construct of intention to stay and the negative construct of intention to quit, while essentially different, also appear to be two sides of the same coin. If an employee has decided to quit, it would be futile to bear further costs on them, whereas, if they intend to stay, they are unlikely to engage in deviant behaviours.
Donne in the Vineyards: Italian‐American Women in the California Wine Industry
Authors: Pinna Pietro 
Published: June 2022

ABSTRACTThis article analyses the participation of Italian‐American women in the California wine industry, paying attention to the interactions between gender and ethnicity. Italian‐American women contributed to the birth and the development of family‐run companies, but their role in wineries was often invisible, as it was regarded as mere support for male business owners, and their power was limited. The work of Italian‐American women did not represent a model of individual emancipation from the family, but carried out a social function of conservation which made it possible for family businesses to thrive. After the Second World War, women such as Rosa Mondavi and Sylvia Sebastiani reinvented their own roles to fit within the models of femininity imposed on the middle class, gaining control over their family businesses and contributing to Italian‐Californian wine culture.
Rheological properties of polysaccharides from Pholiota nameko with different temperature extraction: Concentration, pH, temperature, and saltion
Authors: Geng Xue‐Qing , Liu Chun‐Yu , Wang Liu‐Ya , Jiang Wei , Liu Xiao‐Cui , Zhu Zhen‐Yuan 
Published: June 2022

AbstractCold and hot water extracted polysaccharides (CW‐PNPs and HW‐PNPs) were isolated from Pholiota nameko. The rheological properties of PNPs were investigated by steady shear and oscillatory rheological measurements. The PNPs exhibited typical non‐Newtonian and shear‐thinning behavior, which are affected by PNP concentration, temperature, pH value, salt ion, and concentration. Specifically, the apparent viscosity of the two PNPs solutions at concentration of 1% (w/w) was shown as HW‐PNPs > CW‐PNPs. The apparent viscosity of PNPs decreases under acidic and alkaline conditions and when the temperature rises; K+ and Na+ cause the apparent viscosity of CW‐PNPs to decrease, while Ca2+ and Al3+ are opposite. The addition of four different salt ions all caused the apparent viscosity of the HW‐PNPs to decrease. The results of dynamic rheological experiments show that G′ and G″ showed slightly frequency dependency with G′ exceeding G″ throughout the accessible range of frequency for CW‐PNPs and HW‐PNPs.
Transforming Institutions to Connect Land and Water for Healthy Communities
Authors: Endter‐Wada Joanna , Sternlieb Faith , Welsh Lisa W. , Suedel Burton C. , Madeley Michelle , Boling Edward , Smith Michael D. , Corcelli Leslie , King Jeffrey K. 
Published: June 2022

ABSTRACTInterconnected global environmental and societal risks threaten the health of human and ecological communities. Institutions are avenues through which people can mobilize to respond, but institutional landscapes are fragmented. We focus on the need for institutional change in environmental management and water services to better connect land and water in the United States. Using a historical institutionalist approach and insights from sustainability transitions research, we analyze four diverse examples of connecting land and water occurring across public and private institutions where people are putting innovative perspectives and principles into practice: National Environmental Policy Act, Engineering with Nature®; Water Utilities as Anchor Institutions, and Growing Water Smart. Comparative analysis of these examples focuses on the particular risks these institutions are responding to, how each connects land and water to promote healthy communities, the institutional transformations that are occurring, how problems are being reframed, how leadership and mobilization are driving change, what tools help bridge multiple boundaries, and what new ways of knowing and action strategies are emerging. Our examples focus on transformations within and between institutions in recognition of their importance for driving larger system change. Findings reinforce previous research on the critical role of human agency and boundary spanning in facilitating and steering sustainability transitions.
Lower hand grip in rheumatoid arthritis patients is associated with low finite element analysis using high resolution peripheral quantitative computed tomography scan of the 2nd metacarpophalangeal joint
Authors: Figueiredo Camille Pinto , Perez Mariana Ortega , Sales Lucas Peixoto , Domiciano Diogo Souza , Sampaio‐Barros Marília M. , Caparbo Valeria de Falco , Pereira Rosa Maria Rodrigues 
Published: June 2022

AbstractAimTo evaluate hand function by hand grip test in rheumatoid arthritis (RA) patients, and its association with bone erosions and the estimated bone strength (finite element – FE analysis) through the analysis of the 2nd metacarpal head of the dominant hand using high resolution peripheral quantitative computed tomography (HR‐pQCT).MethodEighty‐two female RA patients between 18‐50 years old were selected. Demographic data, Health Questionnaire Assessment Disability Index (HAQ), Disease Activity Score of 28 joints (DAS)‐28, simplified disease activity index (SDAI) and the hand grip test were set. The HR‐pQCT scans of 2nd metacarpophalangeal joints of the dominant hand of all patients were performed according to SPECTRA group protocols. The images were used to assess bone erosions and FE analysis. The hand grip test was categorized in 2 groups and separately compared (< 18 vs ≥18 kgf). A logistic regression was performed using hand grip test <18 kgf as a dependent variable.ResultsA significant difference was found between the 2 groups regarding HAQ, inflammatory markers (erythrocyte sedimentation rate, C‐reactive protein), DAS‐28, SDAI, total volume of erosion and bone strength parameter (FE analysis – Failure Load [F.Load]). The logistic regression analysis showed that the risk factors associated with hand grip test <18 kgf were higher SDAI (odds ratio [OR] 0.912; 95% CI 0.837‐0.993) and lower values of bone strength parameter (F.Load) (OR 1.007; 95% CI 1.002‐1.012).ConclusionLower values of hand grip test were associated with higher disease activity score‐SDAI and lower bone strength of 2nd metacarpal bone head of the dominant hand evaluated here through a FE analysis using HR‐pQCT scan.
Periosteal block versus intravenous regional anesthesia for reduction of distal radius fractures: A randomized controlled trial
Authors: Beck Sierra , Brunner‐Parker Alana , Stamm Rosemary , Douglas Micheal , Conboy Aileen 
Published: June 2022

AbstractObjectiveWe compare periosteal block and intravenous regional anesthesia (IVRA) as anesthetic techniques for reduction of distal radius fractures when performed by emergency department (ED) clinicians following brief training.MethodsThis was a single‐center, nonblinded randomized controlled trial of a convenience sample of patients presenting with distal radius fractures requiring closed reduction. Primary outcome measure was patient reported fracture reduction pain score, rated on a 100‐mm visual analog scale. Secondary outcomes included adjunct pain medication use, ED length of stay, remanipulation rates, participant satisfaction, clinician assessed efficacy, and clinician‐assessed ease of the procedure.ResultsEighty‐one patients were randomized to receive IVRA (n = 41) or periosteal block (N = 40). Reduction pain scores were not normally distributed. Median (25th–75th percentile) pain scores in participants assigned to IVRA and periosteal block were 5 (1–27.5) and 26 (8.5–63) mm, respectively, (p = 0.007). Use of adjunct medications during reduction was higher for the periosteal block group compared with IVRA (57.5% vs. 22.5%, p = 0.003). Remanipulation rates were 17.5% for periosteal block versus 7.5% for IVRA (p = 0.31). There was no difference in length of stay, patient satisfaction, or clinician's assessed ease of the anesthetic technique. There was a difference in clinician's assessment of efficacy between groups, with IVRA described as “extremely effective” by 65% and periosteal block described as “extremely effective” by 25% (p = 0.003).ConclusionsWhen performed by a diverse group of ED clinicians periosteal block provided inferior analgesia to IVRA but may provide an alternative when IVRA cannot be performed.
Initial public offering, corporate innovation and total factor productivity: Evidence from China
Authors: Wang Yizhong , Lv Linying , Xia Shanqiao 
Published: June 2022

AbstractWe study how listing status affects corporate innovation and total factor productivity (TFP) in the Chinese capital market. Using a new data set of R&D investment and patent information on both industrial unlisted and listed firms, the following empirical findings are obtained: (i) firms experience an increase in innovation input and a decrease in innovation output following the initial public offering (IPO); and (ii) the decrease in innovation output significantly impedes TFP. We identify two possible mechanisms through which IPOs affect innovation activities: agency problems and easier access to funding. The results are robust to the propensity score‐matching approach that addresses selection bias. The analysis reveals that firms face a trade‐off between financing advantages and a potential decrease in innovation and productivity during the transition to public equity markets.
The impacts of tropical storms on food prices: Evidence from China
Authors: Bao Xiaojia , Sun Puyang , Li Jianan 
Published: June 2022

AbstractClimate change is a major source of external shocks to the economy. In this article, we estimate the short‐term impacts of tropical storms on food prices. After matching the track records of tropical storms with retail prices of food products during 1998 and 2012 in China, we find that tropical storms lead to food prices increasing by 2.3%, and the effect lasts more than one month. The positive impacts on prices mainly concentrate on fresh vegetable products. One main channel of price increases caused by tropical storms is the supply‐side shock to the transportation and distribution system. We find limited evidence of price increases driven by demand‐side shocks such as food displacement and food composition changes. The impacts of tropical storms on food price increases lead to a total loss amounting to $92 million each year on average. This study contributes to literature evaluating the price impacts caused by tropical storms and provides policy implications on enhancing food supply resilience.
Icariin inhibits the formation of mitochondria‐associated membranes (MAMs) and improves erectile function in rats treated with prostate radiation
Authors: Deng Chang‐Jian , Li Xiong , Zeng Yang , Jiang Jun , Jiang Rui 
Published: June 2022

AbstractBackgroundErectile function is usually impaired after radiation therapy in prostate cancer patients. eNOS is a key enzyme in the process of erection. Mitochondria‐associated membranes (MAMs) are closely contacted with the production and bioactivity of eNOS.ObjectiveTo study the mechanism of icariin improves the erectile function of rats treated with prostate radiation by controling the expression of MAMs in penile corpus cavernosum.MethodsTwenty 8‐week‐old healthy male SD rats were randomized to four groups: control group, radiation therapy (RT) group, icariin (10 mg/kg/d gavage) group, and RT + icariin (10 mg/kg/d gavage) group (n = 5). In RT group and RT + icariin group, rats were irradiated with X‐rays to the prostate region (total dose 37.5 gray; 7.5 gray/day for 5 days). The maximum intracavernous pressure/mean arterial pressure (ICPmax/MAP), NO concentration and the level of IP3R1, PACS2, FACL4, nNOS, p‐eNOS, and eNOS in rats’ penile cavernous tissue was determined 9 weeks after radiation therapy.ResultsCompared with the control group and the RT + icariin group, the ICPmax/MAP of the RT group was remarkably reduced (p < 0.05). The levels of p‐eNOS/eNOS, nNOS and the concentration of NO in the penile cavernous tissue of the penis in the RT group were remarkably decreased compared to the control group and the RT + icariin group (p < 0.05). The levels of IP3R1, PACS2, and FACL4 in penile cavernous tissue of the RT group were significantly higher than those in the control group and the RT + icariin group (p < 0.05).ConclusionsAfter prostate X‐ray radiotherapy in rats, the formation of MAMs may be increased by increased expression of IP3R1, PACS2, and FACL4 in penile cavernous tissue, resulting in impaired erectile function. Icariin might increase p‐eNOS/eNOS and improve erectile function in rats after prostate radiotherapy by inhibiting the expression of IP3R1, PACS2, and FACL4.
Peripheral blood CD3+ T‐cell gene expression biomarkers correlate with clinical frailty in patients with haematological malignancies
Authors: Fell Geoffrey , Rosko Ashley E. , Abel Gregory A. , Dumontier Clark , Higby Kelly J. , Murillo Anays , Neuberg Donna S. , Burd Christin E. , Lane Andrew A. 
Published: June 2022

SummaryOlder patients with cancer often receive treatment regimens based on their age without considering other objective factors that may influence outcomes. Assessment of frailty can identify older patients who are robust and therefore more likely to benefit from intensive treatment, or conversely, frail and might instead be offered alternative approaches. However, such assessment requires specialised training and dedicated clinical resources. Alternative quantitative biomarkers associated with frailty are lacking. Here, we asked if expression signatures of 74 immune cell, ageing, and senescence‐related messenger RNAs in purified peripheral blood T cells could identify associations with clinical frailty in patients with haematological malignancies. We studied 69 patients between the ages of 36 and 92 years (median 76 years) with leukaemia, lymphoma, or multiple myeloma, across two institutions. Expression of four genes (aryl hydrocarbon receptor [AHR], CD27, CD28, and interleukin‐2 receptor subunit alpha [IL2RA; CD25]) in T cells was associated with frailty, independent of age. An expression‐based regression model had 76% sensitivity and 90% specificity to assign a patient as robust. These data identify measurable peripheral blood correlates of clinical frailty and suggest biomarkers for future prospective assessment.
The molecular rationale for the combination of polatuzumab vedotin plus rituximab in diffuse large B‐cell lymphoma
Authors: Kawasaki Natsumi , Nishito Yukari , Yoshimura Yasushi , Yoshiura Shigeki 
Published: June 2022

SummaryPolatuzumab vedotin (Pola) is an antibody–drug conjugate that targets the B‐cell antigen CD79b and delivers monomethyl auristatin E (MMAE). It is approved in combination with bendamustine and rituximab (Rit) for relapsed/refractory diffuse large B‐cell lymphoma (r/r DLBCL). Understanding the molecular basis of Pola combination therapy with Rit, the key component for the treatment of DLBCL, is important to establish the effective treatment strategies against r/r DLBCL. Here, we examined the rationale for the combination of Pola with Rit using Pola‐refractory cells. We found that treatment with Pola increased CD20 expression and sensitivity to Rit‐induced complement‐dependent cytotoxicity (CDC) in several Pola‐refractory cells. Pola treatment increased phosphorylation of AKT and ERK and both AKT‐ and MEK‐specific inhibitors attenuated the Pola‐induced increase of CD20 and CDC sensitivity, suggesting that these phosphorylation events were required for this combination efficacy. It was revealed that anti‐CD79b antibody increased the phosphorylation of AKT but inhibited the phosphorylation of ERK. In contrast, MMAE potentiated phosphorylation of ERK but slightly attenuated the phosphorylation of AKT. Pola also increased CD20 expression on Pola‐refractory xenografted tumours and significantly enhanced antitumour activity in combination with Rit. In conclusion, these results could provide a novel rationale for the combination of Pola plus Rit.