bluuebunny/crossref_metadata_2025_split huggingface dataset:
Managing supply chains during COVID-19 outbreak: a case of Hong Kong toy manufacturing company
Authors: Kumar Vimal , Verma Pratima , So Tsz-Chun , Singh Arpit , Al Owad Ali 
Published: July 2022

PurposeThis study aims to identify key supply chain challenges and opportunities of the case of Hong Kong toy manufacturing company during the COVID-19 outbreak and develop a comprehensive structural relationship to rank them.Design/methodology/approachIn this study, a toy model company in Hong Kong is considered to discuss about what challenges and opportunities have the biggest impacts on non-necessary goods companies and how to deal with different impacts on entire supply chain flow disruption during COVID-19. A semi-structured interview with five decision-makers from the company was made to give key challenges and opportunities scores. The Technique for Order of Preference by Similarity to Ideal Solution (TOPSIS) technique is used to establish the model and rank them afterward to overcome the challenges.FindingsFrom the data analysis and results, “salary of employee” and “inconvenient transportation” have emerged as top and bottom key challenges respectively. The sequence of organized challenges in the list needs to mitigate one by one in this order to improve the supply chain performance. The “client's orders’ frequency, customer management” and “supplier/partner relationship management” are identified as the top and bottom respectively to develop the opportunities.Research limitations/implicationsThese key challenges and opportunities are identified as contributing attributes and provide the way to measure to improve production, profits and sustainable growth of the toy manufacturing company during a pandemic. Moreover, it helps to improve the distribution level and good planning with appropriate decision making to manage the supply chain performance considering humanitarian aspects during a pandemic outbreak.Originality/valueThe novelty of this study is to identify the key supply chain challenges and opportunities measured by the TOPSIS method to rank them and consider the case of a Hong Kong toy manufacturing company as a case-based approach to measuring its performance during the COVID-19 outbreak.
Challenges faced by financial institutes before onboarding politically exposed persons in undocumented Eastern economies: a case study of Pakistan
Authors: Sultan Nasir , Mohamed Norazida 
Published: July 2022

Purpose
This study aims to evaluate and investigate the existing process of establishing a banking relationship with politically exposed persons.

Design/methodology/approach
This study used qualitative techniques of semi-structured interviews with senior compliance officers of financial institutes in Pakistan.

Findings
This study found that the existing mechanism of identification and verification of politically exposed persons (PEPs) is ineffective. Financial institutes face challenges like the quality of name screening data sets, cost of identification and verification, role and control of the regulator, the influence of politically exposed persons, the opaqueness of laws and international connections of the politically exposed persons. Further, financial Institutes are burdened by regulators to perform robust PEP customer due diligence but do not guide and provide the right tools.

Originality/value
This paper aims to find challenges faced by financial institutes before onboarding the PEPs. Further, very limited studies on this topic have been conducted in Pakistani context.
Can online professional development increase teachers' success in implementing project-based learning in south China?
Authors: Fang Houbin , Wang Lili , Zhou Qi 
Published: July 2022

PurposeThe purpose of this study is to evaluate the effectiveness of one online PD in PBL. Researchers want to investigate if a five-day international online PBL training will prepare teachers to implement PBL in their classrooms. Secondly, the researchers aim to determine if the training provides teachers with sufficient knowledge and support to ensure successful PBL implementation.Design/methodology/approachParticipants were given a 5-day (20 h) online PBL training created by one of the researchers with three frontline teachers. Seven trainers are divided into four groups for four groups of participants. Group A included Grade 1 and Grade 2 teachers, Group B included Grade 3 and Grade 4 teachers, Group C included Grade 5 and Grade 6 teachers, and Group D consisted of Grades 7 through 9 teachers. All the participants were given exactly the same surveys at the beginning and the end of the training.FindingsConsistent with previous studies comparing in person and virtue PD programs, this five-day interactive PD program was effective in increasing teachers' knowledge of and ability to plan and implement PBL projects. Specifically, results showed that teachers' knowledge level of PBL shifted from a shallow understanding of what the name implies to a deeper, more comprehensive, and more concrete understanding of PBL essential concepts, its pedagogical values, specific process involved in a PBL project. In addition, the PD program increased teachers' comfort level and ability of planning and implementing PBL projects across grade levels and subject areas.Originality/valueThis research study supported the previous study results that virtual PD programs can be as effective as in person programs. Further, this is the study discovered the effectiveness of PBL training between the US and China through online format, which has not been conducted literately before. The positive results will be used to promote the online collaboration internationally in the future.
Relationship between parents' health literacy and child health: systematic review
Authors: Batool Syeda Hina , Safdar Muhammad , Eman Saima 
Published: July 2022

PurposeParents' health literacy is an important element to ensure the sound health of children. One of the major purposes of this study was to systematically collect and review the literature that identified the relationship between two variables: parents' health literacy and their child's health.Design/methodology/approachTo meet the purpose, the authors searched four well-reputed research databases such as Web of Science, Scopus, Google Scholar and LISTA (Library, Information Science and Technology Abstracts) comprehensively to collect the relevant research on the topic. Except for books, various types of content from different years were used for this review. The investigators used Preferred Items for Systematic Reviews and Meta-analysis guidelines to select eligible studies for this review. The authors also assessed the quality of the reviewed research in the light of well-reputed quality guidelines shared by Boynton and Greenhalgh (2004).FindingsThe majority of the reviewed studies found a statistically significant relationship between parents' health literacy and the health of their children. Findings also identified that the majority of the reviewed literature scored from 9 to 12 on the quality assessment criteria. Results also highlighted that the majority of the reviewed research on parents' health literacy and child health has been conducted in the USA and utilized quantitative methods to conduct research on the topic under this study.Research limitations/implicationsThis systematic review has multiple theoretical and practical implications for parents, policymakers and researchers.Originality/valueThis is the first systematically collected and reviewed paper on the relationship between parents' health literacy and child health.
On the Parable of the Management Scholars and the Russia–Ukraine War
Authors: Aguinis Herman , Cope Amando , Martin Ursula M. 
Published: July 2022

AbstractWe invoke the parable of “the blind men [sic] and the elephant” to argue that conflicting perspectives from scholars across management subfields preclude a comprehensive understanding of the Russia–Ukraine war. To address this problem, we argue for the need to develop programmatic theories that provide better explanations and predictions and guide empirical research by adopting multilevel and multimethod approaches.
Short‐term effects of comprehensive caregiver supports on caregiver outcomes
Authors: Miller Katherine E. M. , Van Houtven Courtney H. , Kent Erin E. , Gilleskie Donna , Holmes G. Mark , Smith Valerie A. , Stearns Sally C. 
Published: July 2022

AbstractObjectiveTo estimate the association of the Veterans Health Administration (VHA) Program of Comprehensive Assistance for Family Caregivers (PCAFC) implemented in 2011 with caregiver health and health care use.Data SourcesVHA claims and electronic health records from May 2009 to May 2018.Study DesignUsing a retrospective, pre–post study design with inverse probability of treatment weights to address selection into treatment, we examine the association of PCAFC on caregivers who are veterans: (1) outpatient primary, specialty, and mental health care visits; (2) probability of uncontrolled hypertension and anxiety/depression; and (3) VHA health care costs. We compare outcomes for caregivers approved for PCAFC (treatment) to caregivers denied PCAFC (comparison).Data Collection/Extraction MethodsNot applicable.Principal FindingsIn the year pre‐application, we observe similar probabilities of having any VHA primary care (~36%), VHA specialty care (~24%), and VHA or VHA‐purchased mental health care (~22%) for treatment and comparison caregivers. In the year post‐application, treated caregivers had a 5.89 percentage point larger probability of any outpatient VHA primary care (p = 0.002) and 4.34 percentage points larger probability of any outpatient mental health care use (p = 0.014). Post‐application, probabilities of having uncontrolled hypertension or diagnosed anxiety/depression were higher for both treated and comparison groups. In the second year post‐application, treated caregivers had a 1.88 percentage point larger probability of uncontrolled hypertension (p = 0.019) and 4.68 percentage points larger probability of diagnosed anxiety/depression (predicted probabilities: treated = 0.30; comparison = 0.25; p = 0.005). We find no evidence of differences in VHA total costs by PCAFC status.ConclusionsOur findings that PCAFC enrollment is associated with increased health care diagnosis and service use may reflect improved access for previously unmet needs in the population of veteran caregivers for veterans in PCAFC. The costs and value of these increases can be weighed against other effects of the program to inform national policies supporting caregivers.
Perceptions of community members in Australia about the risk factors, symptoms and impacts of dementia: A cross‐sectional questionnaire study
Authors: Mansfield Elise , Watson Rochelle , Carey Mariko , Sanson‐Fisher Rob 
Published: July 2022

AbstractObjectivesEnsuring that the Australian public has an accurate understanding of the characteristics of dementia may assist in improving timely detection of dementia. This cross‐sectional questionnaire study aimed to examine community members' perceptions of the risk factors, symptoms and impacts of dementia.MethodsParticipants were recruited from outpatient units at a major regional hospital and were aged at least 18 years, a patient or an accompanying support person, did not have a dementia diagnosis, had sufficient English knowledge and were well enough to complete a survey. Participants completed a web‐based survey on a touchscreen computer including items exploring knowledge of dementia risk factors, symptoms and perceived impacts if they or a loved one had dementia. Counts and proportions were calculated and perceived impacts of dementia were compared for self versus loved one using a χ2 test.ResultsOf 353 eligible individuals approached, 208 consented and were included in the study. Between 30% and 61% (n = 62–127) of participants believed modifiable factors such as high alcohol consumption and high blood pressure were associated with increased risk of dementia. While a majority of participants (87–96%; n = 164–181) identified memory‐related symptoms, less than one‐third recognised behavioural symptoms. Participants were more likely to identify emotional and practical impacts compared to physical or social impacts as most difficult if they or a loved one had dementia.ConclusionsThere remains a need for increased community education to address knowledge gaps regarding modifiable risk factors, behavioural symptoms and potential impacts of dementia on the individual diagnosed and their carers.
Double Reduction Estimation and Equilibrium Tests in Natural Autopolyploid Populations
Authors: Gerard David 
Published: July 2022

Abstract
Many bioinformatics pipelines include tests for equilibrium. Tests for diploids are well studied and widely available, but extending these approaches to autopolyploids is hampered by the presence of double reduction, the comigration of sister chromatid segments into the same gamete during meiosis. Though a hindrance for equilibrium tests, double reduction rates are quantities of interest in their own right, as they provide insights about the meiotic behavior of autopolyploid organisms. Here, we develop procedures to (i) test for equilibrium while accounting for double reduction, and (ii) estimate the double reduction rate given equilibrium. To do so, we take two approaches: a likelihood approach, and a novel U-statistic minimization approach that we show generalizes the classical equilibrium χ2 test in diploids. For small sample sizes and uncertain genotypes, we further develop a bootstrap procedure based on our U-statistic to test for equilibrium. We validate our methods on both simulated and real data.
Phase II proof‐of‐concept study of atorvastatin in castration‐resistant prostate cancer
Authors: Rushworth Linda K. , Loveridge Carolyn , Salji Mark , MacLeod Martin , Mui Ernest , Sumpton David , Neilson Matthew , Hedley Ann , Alexander Laura , McCartney Elaine , Patel Rachana , Wallace Jan , Delles Christian , Jones Rob , Leung Hing Y. 
Published: July 2022

ObjectivesTo test for evidence of statin‐mediated effects in patients with castration‐resistant prostate cancer (CRPC) as post‐diagnosis use of statins in patients with prostate cancer is associated with favourable survival outcome.Patients and MethodsThe SPECTRE trial was a 6‐weeks‐long proof‐of‐concept single‐arm Phase II treatment trial, combining atorvastatin and androgen deprivation therapy in patients with CRPC (regardless of metastatic status), designed to test for evidence of statin‐mediated effects in patients with CRPC. The primary study endpoint was the proportion of patients achieving a ≥50% drop from baseline in prostate‐specific antigen (PSA) levels at any time over the 6‐week period of atorvastatin medication (PSA response). Exploratory endpoints include PSA velocity and serum metabolites identified by mass spectrometry .ResultsAt the scheduled interim analysis, one of 12 patients experienced a ≥50% drop in PSA levels (primary endpoint), with ≥2 patients satisfying the primary endpoint required for further recruitment. All 12 patients experienced substantial falls in serum cholesterol levels following statin treatment. While all patients had comparable pre‐study PSA velocities, six of 12 patients showed decreased PSA velocities after statin treatment, suggestive of disease stabilization. Unbiased metabolomics analysis on serial weekly blood samples identified tryptophan to be the dominant metabolite associated with patient response to statin.ConclusionsData from the SPECTRE study provide the first evidence of statin‐mediated effects on CRPC and early sign of disease stabilization. Our data also highlight the possibility of altered tryptophan metabolism being associated with tumour response.
Clinical significance and immune landscape of KIR2DL4 and the senescence‐based signature in cutaneous melanoma
Authors: Mao Rui , Ren Zhengyun , Yang Fan , Yang Peng , Zhang Tongtong 
Published: July 2022

AbstractSenescence is an effective barrier to tumor progression. Mutations that inhibit senescence and promote cell division are mandatory for the development of cancer. Therefore, it is particularly important to explore the differences between cutaneous melanoma (CM) patients with severe and mild degrees of senescence. We clustered all the patients with CM in the Cancer Genome Atlas (TCGA) database based on all the genes of the senescence pathway in the CellAge and MSigDB database. The prognosis, immunotherapy effect, tumor microenvironment score, NRAS mutation rate, expression of CD274, CTLA4, and PDCD1, and abundance of CD8+ T and natural killer (NK) cell infiltration in the younger group of patients (YG) were higher than those in the older group (OG). Compared with the American Joint Committee on Cancer (AJCC) stage, the risk scoring system stratified the risk of CM patients and guided immunotherapy more accurately. The nomogram model, which combined the AJCC stage and risk score, greatly improved the ability and accuracy of prognosis prediction. As KIR2DL4 is the core molecule in the risk scoring system (RSS), knocking down the KIR2DL4 of human NK cells in vitro can inhibit the cytotoxicity of NK cells and can also inhibit the secretion of tumor necrosis factor‐α and interferon‐γ by NK cells. In contrast, upregulation of KIR2DL4 can activate the MEK/ERK signaling pathway, which is the activation pathway of NK cells. Our RSS and nomogram model can accurately stratify the risk of CM patients and effectively predict the effect of immunotherapy and prognosis in CM patients.
‘I chose the bad’: Youth's meaning making of being involved in self‐harm content online during adolescence
Authors: Stänicke Line Indrevoll 
Published: July 2022

AbstractThis article aims to explore how young adults (18–23) who have a history of self‐harm experienced involvement in self‐harm content online during adolescence. The qualitative data analysis follows the steps of Interpretative phenomenological analysis and resulted in four meta‐themes: (1) ‘Solitude during adolescence—finally found a place to fit in’, (2) ‘Tempting but dangerous—a game that never should end’, (3) ‘Searching for self—it was like an online diary’ and (4) ‘No one in charge’. Each superordinate theme characterizes essential features of subjective reasons for becoming involved in and their way out of self‐harm content online. Digital involvement is discussed in light of developmental challenges during adolescence—such as exploration of borders, autonomy and self‐identity formation. For lonely people, online involvement with self‐harm content may enable ‘a potential space’ in between reality and fiction sufficient for relational and personal exploration. Involvement in self‐harm content online may cover a need to belong, to express and share problems, and for support. This knowledge should inform clinicians to ask patients about involvement in risk content online and motivate decision‐makers to develop ways to detect and support vulnerable adolescents online and offline.
Heart transplantation after total artificial heart bridging—Outcomes over 15 years
Authors: Chen Qiudong , Chan Joshua , Akhmerov Akbarshakh , Roach Amy , Emerson Dominic , Megna Dominick , Catarino Pedro , Moriguchi Jaime , Chang David , Kittleson Michelle , Geft Dael , Kobashigawa Jon , Chikwe Joanna , Esmailian Fardad 
Published: July 2022

AbstractBackgroundData are limited on outcomes after heart transplantation in patients bridged‐to‐transplantation (BTT) with a total artificial heart (TAH‐t).MethodsThe UNOS database was used to identify 392 adult patients undergoing heart transplantation after TAH‐t BTT between 2005 and 2020. They were compared with 11 014 durable left ventricular assist device (LVAD) BTT patients and 22 348 de novo heart transplants (without any durable VAD or TAH‐t BTT) during the same period.ResultsTAH‐t BTT patients had increased dialysis dependence compared to LVAD BTT and de novo transplants (24.7% vs. 2.7% vs. 3.8%) and higher levels of baseline creatinine and total bilirubin (all p < .001). After transplantation, TAH‐t BTT patients were more likely to die from multiorgan failure in the first year (25.0% vs. 16.1% vs. 16.1%, p = .04). Ten‐year survival was inferior in TAH‐t BTT patients (TAH‐t BTT 53.1%, LVAD BTT 61.8%, De Novo 62.6%, p < .001), while 10‐year survival conditional on 1‐year survival was similar (TAH‐t BTT 66.8%, LVAD BTT 68.7%, De Novo 69.0%, all p > .20). Among TAH‐t BTT patients, predictors of 1‐year mortality included higher baseline creatinine and total bilirubin, mechanical ventilation, and cumulative center volume <20 cases of heart transplantation involving TAH‐t BTT (all p < .05).ConclusionSurvival after TAH‐t BTT is acceptable, and patients who survive the early postoperative phase experience similar hazards of mortality over time compared to de novo transplant patients and durable LVAD BTT patients.
Engagement of Foxh1 in chromatin regulation revealed by protein interactome analyses
Authors: Zhou Jeff Jiajing , Pham Paula Duyen , Han Han , Wang Wenqi , Cho Ken W. Y. 
Published: July 2022

AbstractEarly embryonic cell fates are specified through coordinated integration of transcription factor activities and epigenetic states of the genome. Foxh1 is a key maternal transcription factor controlling the mesendodermal gene regulatory program. Proteomic interactome analyses using FOXH1 as a bait in mouse embryonic stem cells revealed that FOXH1 interacts with PRC2 subunits and HDAC1. Foxh1 physically interacts with Hdac1, and confers transcriptional repression of mesendodermal genes in Xenopus ectoderm. Our findings reveal a central role of Foxh1 in coordinating the chromatin states of the Xenopus embryonic genome.
Revisiting ‘intensive’ blood glucose control: A causal directed acyclic graph‐guided systematic review of randomized controlled trials
Authors: Huang Chi‐Jung , Wang Wei‐Ting , Sung Shih‐Hsien , Chen Chen‐Huan , Lip Gregory Y. H. , Cheng Hao‐Min , Chiang Chern‐En 
Published: July 2022

AbstractAimTo clarify the importance of HbA1c reduction and antidiabetic drug use in preventing major adverse cardiovascular events (MACE) for patients with type 2 diabetes (T2D).Materials and MethodsWe conducted an updated systematic review of contemporary large randomized controlled trials assessing the relative efficacy and safety of antidiabetic drugs with less hypoglycaemia risk in adult T2D patients. Mixed‐effects meta‐regression was performed to examine the associations of HbA1c reduction with subsequent risk of macrovascular and microvascular events. We evaluated the potential mediating role of HbA1c reduction in the relationship between antidiabetic drugs and MACE.ResultsEighteen placebo‐controlled trials comprising 155 610 participants were included. The effects of treatment differed among antidiabetic drug classes for most adverse outcomes with high heterogeneity (I2: 63.7%‐95.8%). Mean HbA1c reduction was lowest with dipeptidyl peptidase‐4 inhibitors (0.30%), followed by sodium‐glucose co‐transporter‐2 inhibitors (0.46%), and was highest with glucagon‐like peptide‐1 receptor agonists (0.58%) and thiazolidinediones (0.60%). Lower relative risks of MACE were significantly associated with larger reductions in achieved HbA1c (β −0.3182; 95% CI: −0.5366 to −0.0998; P = .0043), even after adjusting for drug classes. When considering HbA1c lowering as a mediator to be controlled, beneficial effects owing to specific antidiabetic treatment for MACE were not observed (χ2 = 1.4494; P = .6940). The proportion mediated by HbA1c reduction was 50.0%‐63.5% for these antidiabetic agents.ConclusionsThe main benefits of antidiabetic agents might result from the reduction in blood sugar levels and are generally independent of drugs used. Risk reduction in MACE was proportional to the magnitude of HbA1c decrease conferred by antidiabetic agents with less hypoglycaemic hazard.