bluuebunny/crossref_metadata_2025_split huggingface dataset:
Payments to key opinion leader physicians and drug sales of top pharmaceutical companies during the COVID-19 pandemic
Authors: Sandoval José Luis , Friedlaender Alex , Addeo Alfredo , Weiss Glen J. 
Published: January 2022

AbstractBackgroundThe unprecedented context of the COVID-19 pandemic poses the opportunity to study several questions in circumstances that would probably not otherwise occur. We sought to determine the dynamics of pharmaceutical company drug sales revenue, market capitalization and payments to physicians during the pandemic, focusing on payments to so-called key opinion leaders (KOLs).MethodsWe analyzed the CMS Open Payments data of 15 top pharmaceutical company general payments to US physicians. We calculated total payments per year for all physicians, KOLs and 2018 KOLs in subsequent years. Drug-related fold changes in payments, drug revenues and company market capitation were calculated using Q1-2018 as reference. Yearly differences in payments, drug sales revenue and market capitalization were tested using generalized estimation equations (GEE). A double-sided p<0.05 was considered significant.ResultsThe analyzed dataset comprised 8,563,872 payments to 382,779 physicians. In 2020, we observed a reduction in payments to physicians and KOLs compared to prior years. The total amount per KOL physician per company also decreased for each year for KOLs and the 2018 KOLs in the subsequent years. Payments per drug, but neither drug revenues nor pharmaceutical company market capitalization, followed a downward trend in 2020 compared to prior years. GEE analysis confirmed that, compared to 2018, the decrease in payments to KOLs overall and for the top drugs of each company was statistically significant. Yet, no significant differences in drug sales revenue and market capitalization was observed.ConclusionsA substantial and significant reduction in payments to KOLs during the first fiscal year of the COVID-19 pandemic was not associated with a reduction in drug sales revenue of blockbuster drug products and the market capitalization of 15 top pharmaceutical companies. Overall, these findings suggest that a substantial part of pharmaceutical payments to KOLs do not appear to impact top drug sales revenues.
Modelling COVID-19 Vaccine Breakthrough Infections in Highly Vaccinated Israel – the effects of waning immunity and third vaccination dose
Authors: Feng Anyin , Obolski Uri , Stone Lewi , He Daihai 
Published: January 2022

AbstractIn August 2021, a major wave of the SARS-CoV-2 Delta variant erupted in the highly vaccinated population of Israel. The Delta variant has a transmission advantage over the Alpha variant, and thus replaced it in approximately two months. The outbreak led to an unexpectedly large proportion of breakthrough infections (BTI)-- a phenomenon that received worldwide attention. The BTI proportion amongst cases in the age group of 60+ years reached levels as high as ∼85% in August 2021. Most of the Israeli population, especially those 60+ age, received their second dose of the vaccination, four months before the invasion of the Delta variant. Hence, either the vaccine induced immunity dropped significantly or the Delta variant possesses immunity escaping abilities. In this work, we analyzed and model age-structured cases, vaccination coverage, and vaccine BTI data obtained from the Israeli Ministry of Health, to help understand the epidemiological factors involved in the outbreak. We propose a mathematical model which captures a multitude of factors, including age structure, the time varying vaccine efficacy, time varying transmission rate, BTIs, reduced susceptibility and infectivity of vaccinated individuals, protection duration of the vaccine induced immunity, and the vaccine distribution. We fitted our model to the cases among vaccinated and unvaccinated, for <60 and 60+ age groups, to address the aforementioned factors. We found that the transmission rate was driven by multiple factors including the invasion of Delta variant and the mitigation measures. Through a model reconstruction of the reproductive number R0(t), it was found that the peak transmission rate of the Delta variant was 1.96 times larger than the previous Alpha variant. The model estimated that the vaccine efficacy dropped significantly from >90% to ∼40% over 6 months, and that the immunity protection duration has a peaked Gamma distribution (rather than exponential). We further performed model simulations quantifying the important role of the third vaccination booster dose in reducing the levels of breakthrough infections. This allowed us to explore “what if” scenarios should the booster not have been rolled out. Application of this framework upon invasion of new pathogens, or variants of concern, can help elucidate important factors in the outbreak dynamics and highlight potential routes of action to mitigate their spread.
Anti-PEG Antibodies Boosted in Humans by SARS-CoV-2 Lipid Nanoparticle mRNA Vaccine
Authors: Ju Yi , Lee Wen Shi , Pilkington Emily H. , Kelly Hannah G. , Li Shiyao , Selva Kevin J. , Wragg Kathleen M. , Subbarao Kanta , Nguyen Thi H.O. , Rowntree Louise C. , Allen Lilith F. , Bond Katherine , Williamson Deborah A. , Truong Nghia P. , Plebanski Magdalena , Kedzierska Katherine , Mahanty Siddhartha , Chung Amy W. , Caruso Frank , Wheatley Adam K. , Juno Jennifer A. , Kent Stephen J. 
Published: January 2022

ABSTRACTHumans commonly have low level antibodies to poly(ethylene) glycol (PEG) due to environmental exposure. Lipid nanoparticle (LNP) mRNA vaccines for SARS-CoV-2 contain small amounts of PEG but it is not known whether PEG antibodies are enhanced by vaccination and what their impact is on particle–immune cell interactions in human blood. We studied plasma from 130 adults receiving either the BNT162b2 (Pfizer-BioNTech) or mRNA-1273 (Moderna) mRNA vaccines, or no SARS-CoV-2 vaccine for PEG-specific antibodies. Anti-PEG IgG was commonly detected prior to vaccination and was significantly boosted a mean of 13.1-fold (range 1.0 to 70.9) following mRNA-1273 vaccination and a mean of 1.78-fold (range 0.68 to 16.6) following BNT162b2 vaccination. Anti-PEG IgM increased 68.5-fold (range 0.9 to 377.1) and 2.64-fold (0.76 to 12.84) following mRNA-1273 and BNT162b2 vaccination, respectively. The rise in PEG-specific antibodies following mRNA-1273 vaccination was associated with a significant increase in the association of clinically relevant PEGylated LNPs with blood phagocytes ex vivo. PEG antibodies did not impact the SARS-CoV-2 specific neutralizing antibody response to vaccination. However, the elevated levels of vaccine-induced anti-PEG antibodies correlated with increased systemic reactogenicity following two doses of vaccination. We conclude that PEG-specific antibodies can be boosted by LNP mRNA-vaccination and that the rise in PEG-specific antibodies is associated with systemic reactogenicity and an increase of PEG particle–leukocyte association in human blood. The longer-term clinical impact of the increase in PEG-specific antibodies induced by lipid nanoparticle mRNA-vaccines should be monitored.
Mutual relationships between head injury and conduct problems in children aged 9 months to 14 years in the UK Millennium Cohort Study
Authors: Brandt Valerie , Hall Charlotte , Eisenbarth Hedwig , Hall James 
Published: January 2022

AbstractBackgroundResearch suggests a link between acquired head injury and signs of conduct disorder, with a majority of findings based on retrospective reports and comparison samples. The relationship between head injuries and conduct problems and how they may influence one another during development is currently unclear. This study aimed to investigate direct and indirect associations between head injury and conduct problems through to early adolescence.MethodsData from the UK Millennium Cohort Study was used to investigate the relationship between conduct problems as assessed by the Strengths and Difficulties Questionnaire and parent reported head injury over time, at ages 9 months, 3, 5, 7, 11 and 14 years, using a cross-lagged path analysis. This is data from 18,552 children, participating in a UK cohort study that is representative of the UK population. We included 7,041 (3,308 male) children, who had full information about head injuries and conduct problems at age 14.ResultsWe found a mutual association between childhood head injuries and conduct problems but with distinct timings: Head injury between 5-7 years predicted greater chance of conduct problems at age 11 and 14 years, while greater conduct problems at 5 years predicted a significantly greater chance of a head injury at age 7-11 years.ConclusionsThese findings have important implications for the timing of preventive and ameliorative interventions. Prior to school entry, interventions aiming to reduce conduct problems would appear most effective at reducing likelihood of head injuries in future years. However, equivalent interventions targeting head injuries would be better timed either as children are entering formal primary education, or soon after they have entered.
COVID-19 impact on Socio-economic and Health Interventions: A Gaps and Peaks analysis using Clustering Approach
Authors: Mahanta Hridoy Jyoti , Sastry G. Narahari 
Published: January 2022

AbstractA quantifiable model to describe the peaks and gaps during the several waves of COVID-19 is generated and applied to the progression of 120 countries. The number of waves encountered and how many more to be encountered is a question which is currently explored by all the scientific communities. In the same quest, an attempt has been made to quantitatively model the peaks and the gaps within them which have been encountered by 120 most affected countries from February 2020 – December 2021. These 120 countries were ranked based on the number of confirmed cases and deaths recorded during this period. This study further cluster these countries based on socio-economic and health interventions to find an association with three dependent features of COVID-19 i.e. number of confirmed cases, deaths and death-infectivity rate. The findings in this study suggests that, every wave had multiple peaks within them and as the number of peaks increased, predicting their growth rate or decline rate turns to be extremely difficult. However, considering the clusters which share the common features even with diverse countries, there is some possibility to predict what might be coming next. This study involves exhaustive analysis of reliable data which are available in open access and marks an important aspect to the COVID-19 research communities.
The link between company performance and supply chain orientation from the perspective of halal SMEs
Authors: Usmanova Kamila , Wang Daoping , Sumarliah Eli , Fauziyah Fauziyah 
Published: January 2022

PurposeThis study aims to examine the links between company performance (CP) and supply chain (SC) orientation considering halal small and medium-sized enterprises (SMEs) in Kazakhstan. The SC orientation framework integrates three aspects to determine CP, i.e. credibility, commitment and top management support.Design/methodology/approachHalal SMEs were reviewed; 271 valid responses were obtained and scrutinised, employing the partial least squares structural equation modelling technique.FindingsThe credibility of SC stakeholders performs the main impact on the CP of halal SMEs in Kazakhstan. Meanwhile, commitment and top management support show fewer influences, although they significantly impact CP.Originality/valueThis study confirms the relationships between SC orientation and CP from the perspective of halal SMEs. The social capital theory was applied to explain these relationships. It is the initial attempt to investigate such relationships in a post-Soviet Union country.
Cryptocurrencies and portfolio diversification in an emerging market
Authors: Letho Lehlohonolo , Chelwa Grieve , Alhassan Abdul Latif 
Published: January 2022

PurposeThis paper examines the effect of cryptocurrencies on the portfolio risk-adjusted returns of traditional and alternative investments within an emerging market economy.Design/methodology/approachThe paper employs daily arithmetic returns from August 2015 to October 2018 of traditional assets (stocks, bonds, currencies), alternative assets (commodities, real estate) and cryptocurrencies. Using the mean-variance analysis, the Sharpe ratio, the conditional value-at-risk and the mean-variance spanning tests.FindingsThe paper documents evidence to support the diversification benefits of cryptocurrencies by utilising the mean-variance tests, improving the efficient frontier and the risk-adjusted returns of the emerging market economy portfolio of investments.Practical implicationsThis paper firmly broadens the Modern Portfolio Theory by authenticating cryptocurrencies as assets with diversification benefits in an emerging market economy investment portfolio.Originality/valueAs far as the authors are concerned, this paper presents the first evidence of the effect of diversification benefits of cryptocurrencies on emerging market asset portfolios constructed using traditional and alternative assets.
A hotel stay for a respite from work? Examining recovery experience, rumination and well-being among hotel and bed-and-breakfast guests
Authors: Chen Chun-Chu , Han Jiyoon (Jennifer) , Wang Yao-Chin 
Published: January 2022

Purpose
This paper aims to examine the relationship among guests’ lodging recovery experience, work-related rumination, guest satisfaction and well-being, within the context of hotels and bed and breakfasts (B&Bs).

Design/methodology/approach
The sample included 823 Taiwanese full-time workers. The proposed relationships were tested using partial least square structural equation modeling, and the moderating effects of accommodation types were tested using multi-group analysis.

Findings
The research findings indicate that staying at a hotel or B&B provides a respite from work and reduces negative, repetitive thoughts about work issues (work-related rumination). These recovery effects then contribute to customer satisfaction and hedonic and eudaimonic well-being.

Practical implications
The findings indicate that practitioners need to develop products that could reduce customers’ negative emotional attachments to work and enhance the well-being of customers in a stressful society, which could ultimately contribute to promoting the public health of full-time workers.

Originality/value
To the best of the authors’ knowledge, this study is the first to examine the stress-recovery aspect of lodging experiences and their impacts on customer satisfaction and well-being. Further insights are demonstrated with the inclusion of work-related rumination.
Learning-based dynamic capabilities in closed-loop supply chains: an expert study
Authors: Ritola Ilkka , Krikke Harold , Caniëls Marjolein C.J. 
Published: January 2022

PurposeProduct returns information gives firms an opportunity for continuous strategic adaptation by allowing them to understand the reasons for product returns, learning from them and improving their products and processes accordingly. By applying the Dynamic Capabilities (DCs) view in the context of closed-loop supply chains (CLSC), this study explores how firms can continuously learn from product returns information.Design/methodology/approachThis study adopts a qualitative Delphi study-inspired approach. Experts from industry and academia are interviewed in two interview rounds. First round of interviews are based on extant research, while the second round allows the experts to elaborate and correct the results.FindingsThis study culminates into a conceptual model for incremental learning from product returns information. The results indicate incremental learning from product returns can potentially lead to a competitive advantage. Additionally, the authors identify the sources of information, capabilities along with their microfoundations and the manifestations of product return information. Three propositions are formulated embedding the findings in DC theory.Research limitations/implicationsThis study supports extant literature in confirming the value of product returns information and opens concrete avenues for research by providing several propositions.Practical implicationsThis research elucidates the practices, processes and resources required for firms to utilize product returns information for continuous strategic adaptation. Practitioners can use these results while implementing continuous learning practices in their organizations.Originality/valueThis study presents the first systematic framework for incremental learning from product returns information. The authors apply the DC framework to a new functional domain, namely CLSC management and product returns management. Furthermore, the authors offer a concrete example of how organizational learning and DC intersect, thus advancing DC theoretical knowledge.
Entry-level job pursuit intention: assessing person-environment fit in India
Authors: Sengupta Atri , Mittal Shashank 
Published: January 2022

PurposePerson-environment (PE) fit theory suggests that value congruence (fit) leads to the job pursuits intention (Cable and Judge, 1996) which is also influenced by cultural norms (Ma and Allen, 2009). Due to stringent job market condition along with its people, as a part of collectivistic culture, having poor self-concept consistency, value congruence may unfold different phenomenon in Indian context. Therefore, the present study intends to explore the existing fit theory on different cultural norms and different job market condition with entry-level job pursuits as participants.Design/methodology/approachThe fit was measured both objectively and subjectively in a mixed method research design. Top 100 institutes ranked in NIRF (National Institutional Ranking Framework) (under Management category) were approached for data collection and 41 institutes agreed to participate. Data were collected in four phases from 2,714 entry-level job pursuits and domain experts based on web-based job advertisements. Krippendorff's alpha was calculated for measuring objective fit, and the subjective fit was measured through quadratic structural equation modeling with response surface analysis.FindingsFindings revealed lack of value congruence objectively; and no influencing role of subjective fit in job pursuits intention. This indicated that neither Indian employers nor entry-level job pursuits were concerned about value congruence. The post-hoc analysis suggested that poor self-concept consistency as a cultural norm led to such atypical findings.Originality/valueThe present study suggests that fit may lead to different phenomena of entry-level job pursuits intention with different contextual and cultural norms.
Does corporate social responsibility affect dividend policy? Empirical evidence in the French context
Authors: Ben Salah Olfa , Ben Amar Anis 
Published: January 2022

PurposeThe purpose of this paper is to focus on the impact of corporate social responsibility (CSR) on dividend policy in the French context. In addition, the authors seek to determine if the individual components of CSR influence dividend policy.Design/methodology/approachThis study uses panel data methodology for a sample of French non-financial firms between 2008 and 2018. Generalized least squares method is used to estimate the models.FindingsUsing panel data methodology for a sample of 825 observations for the period 2008–2018, this study finds a positive impact of CSR practices on dividend policy. The authors also find that individual components of CSR positively influence dividend policy. To check the robustness of the results, this study further runs a sensitivity tests, including an alternative measure of dividend policy, all of which confirm the findings.Practical implicationsThis study has examined the impact of CSR on dividend policy in France and may have implications for regulatory, investors, analysts and academics. First, the involvement in CSR best practices encourages companies to pay more dividends to investors. Therefore, investors are more motivated to invest in socially responsible firms than socially irresponsible firms. Second, given the association of CSR with the quality of accounting information and financial markets, regulators should step up recommendations relating to the different societal dimensions of CSR.Originality/valueWhile little previous work has focused on the causal link between CSR and dividend policy, this research is the first, to the authors’ knowledge, to have looked at the impact of CSR on dividend policy in France.
Presenting a framework for the successful entry of women entrepreneurs into green entrepreneurship
Authors: Fallah Mohammad Reza , Soori Maryam 
Published: January 2022

Purpose
The concentration of women entrepreneurs on influential events such as the development of green entrepreneurship, which lead to the coordination and dynamic balance between economic and environmental goals, can create a bright future for businesses with sustainable and environmentally friendly architecture. The main purpose of this study is to provide a framework for the successful entry of women entrepreneurs into green entrepreneurship.

Design/methodology/approach
The present qualitative applied descriptive-analytical study was conducted on a population of women entrepreneurs working in green businesses. This population was obtained by the non-probability chain sampling method and an exploratory interview with the saturation of 12 individuals. Thematic analysis was used to analyze the findings.

Findings
The results revealed that creating shared value, inclusive social acceptance, multifaceted interactions and green dynamic bedding are effective in the entry of women entrepreneurs into green entrepreneurship in the form of “competitive empowerment” and “multiplied green synergy”. Thus, managers and planners should consider some factors, including shared value, social acceptance, inclusive acceptance, building green culture, knowledge flows, multiple participation, networking dimension, green marketing, competitiveness, creating platforms, green technologies and risk management.

Originality/value
This research tries to present a framework for the entry of women entrepreneurs into green entrepreneurship area.
Ethical leadership, perceived leader–member ethical communication and organizational citizenship behavior: development and validation of a multilevel model
Authors: Abu Bakar Hassan , Connaughton Stacey L. 
Published: January 2022

PurposeThis study provides a systematic testing of ethical leadership and organizational citizenship behavior (OCB) by examining the underlying mechanisms of leader motivation language on ethics through which ethical leadership influences followers’ OCB at the team level.Design/methodology/approachA multilevel model was validated via with structural equation modeling (SEM) from hierarchical linear modeling (HLM) based on data collected in a Malaysian organization.FindingsThe perceived leader–member ethical communication at the team-level makes a unique contribution beyond the ethical leadership in explaining OCBs.Originality/valuePerceived leader–member ethical communication mediates the relationship between ethical leadership and OCB.