bluuebunny/crossref_metadata_2025_split huggingface dataset:
Esthetic Assesement of Maxillary Incisor Inclination For Varying Mandibular Positions in Smiling Profile`- a Photomorphic Study
Authors: PASHA MANSOOR , ARSHAD FAISAL , KUMAR.H.C SHASHI , BHATIA SAURABH , GOWDA E MAHESH 
Published: June 2022

Abstract
Aim of studyTo assess the relationship between desired inclination of the maxillary incisors in smiling profile of a male subject with diverse positions of mandible in addition to explicate if or not the occupation of a rater and gender performed a sizeable position in its determination.MethodologySmiling Profile photograph of male subject along with ideal facial traits was photo morphed to attain three different mandibular sagittal positions with 5 mm decrements and increments ranging from – 5 mm to + 5 mm. The inclination of the maxillary incisors was adjusted from – 10 to + 10 in 5 increments at each mandibular profile. A general of eighty raters (20 General dentists, 20 orthodontists, 20 maxillofacial surgeons, and 20 laypersons) have been invited to grade every picture with the usage of a Likert-kind score scale.ResultsIn -5mm and + 5mm mandibular positions, moderately proclined (+ 5° labial incisor inclinations) and the most retroclined (-10° palatal incisor inclination) have been identified as the most as well as the least attractive pictures, accordingly with almost all categories. For orthognathic mandible, the picture with the most retroclined (-10° palatal incisor inclination) was identified as the least attractive, but most attractive profile was inconclusive. Gender of raters also played an important role in ratings of certain pictures.ConclusionMajority of raters decided towards moderate inclination (+ 5° labial) of maxillary incisors in sense of retrusion (-5mm mandibular position) and in protrusion of mandible (+ 5mm mandibular position) preference was given to most proclined inclination (+ 10° labial), while for usual mandibular position (orthognathic), the recommended incisor inclination was not conclusive. Also, the gender of the raters had influence on the ranking of the images in all groups except for oral surgeons.
Use of activated Chromolaena odorata biomass for the removal of crystal violet from aqueous solution: Kinetic, Equilibrium and Thermodynamic study
Authors: Soosai Michael Rahul , Moorthy Innasi Muthu Ganesh , Varalakshmi Perumal , Syed Asad , Elgorban Abdallah Mohamed , Rigby Sean Patrick , Natesan Sivrajasekar , Gunaseelan Sathaiah , Joshya Yonas Camy , Baskar Rajoo , Kumar Rajaram Shyam , Karthikumar Sankar 
Published: June 2022

Abstract
In the present study, biomass from the Chromolaena odorata plant's stem was activated using sulfuric acid to absorb crystal violet (CV) dye. The adsorption operation of CV dye was studied considering the effect of variables like pH, initial dye concentration, time, adsorbent dosage, and temperature. The pseudo-second-order equation best fitted the kinetic study, and thermodynamic parameters calculated were activation energy (9.56 kJ/mol), change in Gibbs energy (81.43 to 96.7 kJ/mol), enthalpy change (6.89 kJ/mol), and entropy change [-254.4 J/ (mol K)]. Response surface methodology (RSM) estimated at pH (4.902), adsorbent dosage (8.33 g/L), dye concentration (82.30 ppm), temperature (300.13 K) dye removal of 97.53% is possible. FTIR, SEM, XRD, BJH, and BET confirmed adsorption operation. The adsorbent can be reused for 5 cycles effectively. Langmuir isotherm best fitted the adsorption operation was used for designing a theoretical single-stage batch adsorber for large-scale operation.
Axenfeld-Rieger syndrome：A novel histopathologic finding associated with corneal abnormalities
Authors: Yu Ting , Dai Zhihao , Peng Rongmei , Xiao Gege , Zhang Pei , Ma Siyi , Hong Jing 
Published: June 2022

Abstract
Background: Axenfeld-Rieger syndrome (ARS) is a rare kind of anterior segment dysgenesis (ASD). The most common ocular features of ARS are posterior embryotoxon and iris hypoplasia, while some patients may manifest as corneal opacity and edema. However, the current understanding of how ARS affects the cornea is still incomplete. This study reports a novel histopathological finding of Axenfeld-Rieger syndrome (ARS), complicating corneal abnormalities, including congenital corneal opacity and irreversible endothelial decompensation.Methods: This retrospective study included 6 eyes of 3 ARS patients who underwent keratoplasty for irreversible endothelial decompensation from May 2016 to January 2019. No eye had a history of surgery or glaucoma. We reviewed the data of epidemiology, clinical manifestations and pathological examinations.Results: Five eyes developed irreversible endothelial decompensation, among which 4 were born with corneal opacity. One eye exhibited transparent cornea but showed a continuous loss of endothelial cells in the absence of surgery and glaucoma thereafter. Anterior segment optical coherence tomography photographs showed that anterior synechia existed in the area with corneal opacities, where we found the interlayer splitting of the Descemet membrane inserted by hypoplastic iris and a basement membrane-like structure under a light microscope. Conclusions: Anterior synechia might be associated with corneal abnormalities in ARS patients. The novel histopathologic finding revealed the internal relation between anterior segment dysgenesis and would help explore the inner mechanism of corneal abnormalities in ARS.
Integrating computational fluid dynamic, artificial intelligence techniques, and pore network modeling to predict relative permeability of gas condensate
Authors: Zeinedini Ehsan , Dabir Bahram , Dadvar Mitra 
Published: June 2022

Abstract
The formation of gas condensate near the wellbore affects the gas liquid two-phase flow between the pores. It may occur in the path between two pores depending on the thermodynamic conditions of the single-phase gas flow, two-phase gas liquid annular flow or the closed path of condensate in throat. To model the behavior of gas condensate in a network of pores, relative permeability and naturally pressure drop should be calculated. In this study, the flow characteristics (pressure drop) between the pores at different physical and geometric conditions were obtained using computational fluid dynamic (CFD). As CFD is time-consuming, its results were transferred to an artificial neural network (ANN) model and the ANN model was trained. For calculating the pressure drop, the CFD was replaced with the ANN model. In addition, instead of utilizing empirical correlations, to compute the accurate value of condensate formed in throats' corners at every time step, the flash calculation using Esmaeilzadeh-Roshanfekr equation of state was performed, and closed throats were specified. This creates an accurate estimation of gas and condensate distribution in the pore network. Furthermore, the value of condensate that transferred to the adjacent throats was computed using Poiseuille's law. The results showed that the proposed ANN based proxy model has ability to promote the speed of calculation in gas condensate simulation, considering dynamic change of relative permeability curves as function of saturation of gas condensate. Also, it was found that the relative permeability obtained by the proposed model is in good agreement with the experimental data. By entering the fractures pattern in the network model and predicting relative permeability of gas and condensate by the proposed method, the role of fractures in the production of gas condensate in such reservoirs could be predicted. Dynamic changes due to the relative permeability of gas and condensate as function of saturation can be entered into the reservoir simulation in order to optimize inertia and positive coupling phenomena to maximized condensate production in gas condensate reservoir.
Clonality analysis of Sclerosing Angiomatoid Nodular Transformation in Spleen
Authors: Han Xiujuan , Ma Li , Chen Lin , Xue Li 
Published: June 2022

Abstract
Aims: Use clonality study to detect sclerosing angiomatoid nodular transformation (SANT) of the spleen and to explore the essence and pathogenesis of SANT.Methods: All SANT cases was performed by clonality analysis and in situ hybridization for the presence of EBV encoded small RNAs (EBER). Immunohistochemisty were used to classify the character of SANT, hemangioma. ﻿Results: The results of histological and immunohistochemical detection show the obstruction of arterioles and the passive congestion of venules in red pulp might participate in the formation of SANT. The results of clonality analysis show polyclonality was demonstrated in SANT nodules and the surrounding spleen parenchyma.Conclusion: SANT is a benign proliferative lesion. Combined with the immunohistochemisty, clonality analysis can be an useful tool for differential diagnosis of these splenic lesions.
Prognostic and immunological potential of PPM1G in lung adenocarcinoma
Authors: Yin Rongjiang , Qu Li , Wang Zhanqing , Tang Jian , Yang Donglin , Gu Hua , Du Pengchao , Dong Menghua 
Published: June 2022

Abstract
Background
Lung cancer is one of the malignant tumors with the worst incidence rate and mortality, and the prognosis is very poor. PPM1G is a serine/threonine phosphatase, which is involved in the proliferation, invasion and metastasis of tumor cells. However, there are few reports on the role of PPM1G in lung adenocarcinoma (LUAD).
Methods
In this study, We used public data from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases to evaluate the expression of PPM1G in LUAD and the relationship between PPM1G expression and prognosis of patients with LUAD.Immunohistochemical staining of PPM1G in lung cancer tissues was detected by HPA database. The correlation between PPM1G and cancer immune signatures was analyzed by single sample gene set enrichment analysis (SSGSEA) on TCGA databases. Kaplan-Meier method was used for survival analysis. Univariate and multivariate Cox regression were used to analyze the prognosis.
Results
Our results showed that PPM1G is highly expressed in cancer tissues of LUAD. The high expression of PPM1G was related with poor clinical stage, T stage, N stage and overall survival in LUAD. We screened 29 genes related to PPM1G and closely related to the cell cycle of LUAD patients. The expression of PPM1G was positively correlated with immune cells TGD, Th2 cells, NK cd56dim cells, and was negatively correlated with B cells, Mast cells, pDC, T helper cells, Macrophages, T cells,CD8 T cells, Tcm, Tem, Neutrophils and TFH. PPM1G was positively correlated with immune detection points.
Conclusions
In conclusion, PPM1G may be involved in the control of lung cancer cell cycle and is associated with prognosis and immune infiltration in patients with LUAD.
Metabolomics analysis of plasma identifies aberrant amino acids and lipids metabolism in the patients with acute anterior uveitis
Authors: zhang xiaobo , xie bintao , ma hua , dong lingqin , Wang Yuqin , Chi Zailong 
Published: June 2022

Abstract
Background
Acute anterior uveitis (AAU) is a severe ocular inflammatory disease and the metabolic characteristics are still unclear. To investigate the potential molecular biomarkers and to understand the metabolic response of AAU.
Methods
Untargeted plasma, which included 181 AAU patients and 99 non-uveitic controls, metabolomics analysis was conducted in this study based on ultra-performance liquid chromatography mass spectrometry (UPLC-MS).
Results
Eighteen and seven significant changed metabolites were found according to the variable importance in the projection value from orthogonal partial least-squares discriminant analysis (OPLS-DA), p value from univariate analysis and fold change for positive and negative mode, respectively. The AAU metabolomics signature indicated increased 10 amino acids (Glycyltyrosine, Pyroglutamic acid, L-Aspartyl-4-phosphate, Brassica oleracea Alkaloid, L-Glutamic acid, gamma-Glutamyl-S-methylcysteine sulfoxide, Tryptophyl-Glutamine, Diaminopimelic acid, 3-Aminoisobutanoic acid, Glycylproline), 7 lipids (3-Deoxyfructose, Maltitol, PC(20:2(11Z,14Z)/15:0), Cholesterol, PC(22:2(13Z,16Z)/16:1(9Z)), PC(16:1(9Z)/20:0), Cholesterol sulfate), one flavonoids (Quercetin) and two carbohydrates (Sorbitol, N-Acetylneuraminic acid), and decreased 5-Hydroxyindoleacetic acid, L-Histidine, Acetyl-N-formyl-5-methoxykynurenamine, Theophylline and 3-Hydroxybenzoic acid in AAU compare with the control group in both positive and negative modes. Pathway analysis indicated D-Glutamine and D-glutamate metabolism and Histidine metabolism were significantly altered in AAU. Several potential biomarkers for AAU diagnosis were selected by receiver operating characteristic curve (ROC) analysis.
Conclusions
Our study uncovers a significant difference of plasma metabolic profile for AAU disease. These changes of metabolites in plasma may improve our understanding of the pathophysiology of AAU disease. Further studies are still needed to validate our findings and investigate the function of altered metabolites.
Neonatal Hypoxic-Ischemic Encephalopathy: Single Tertiary Centre Experience
Authors: Alanazi Jawaher , AlMuqbil Mohammed , Alsaif Nada , Baarmah Duaa , Altwaijri Waleed , Alrumayyan Ahmad , Alrifai Muhammad Talal , Othman Fatmah , Alsaif Saif 
Published: June 2022

Abstract
Purpose
This study aimed to determine the factors associated with Neonatal hypoxic-ischemic encephalopathy (HIE) and its neurodevelopmental outcomes.
Methods
A case-control study of infants delivered at King Abdulaziz Medical City, Riyadh, Saudi Arabia, was carried out from 2015 to 2019. Newborns with an admission diagnosis of HIE were identified, and controls were matched for the case. The electronic medical records were used to extract the clinical data for each case. The HIE cases were followed for 24 months to determine their neurodevelopmental outcomes.
Results
The sample included 60 infants diagnosed with HIE and 234 infants as controls, primarily males (56%) with mean gestational age of 38 weeks (SD 1.6). According to Sarnat staging, 36% of the HIE cases (22 patients) had stage 2 encephalopathy, while 35% of infants were at stage 3. Children with HIE were twice as likely to be born to mothers with maternal comorbidities, and more likely to have prepartum and intrapartum complications than the control group. The follow-up of neurodevelopmental outcomes at 24 months for the HIE infants indicated no delays in development of gross motor skills (76%), fine motor skills (78%), language skills (67%), and social skills (78%).
Conclusion
Maternal comorbidities and prepartum or intrapartum complications were more prevalent in the HIE group. HIE severity grade can be used as a prognostic, predictive tool for neurodevelopmental outcomes. Neurodevelopment follow up for at least 24 months is necessary to enhance care and rehabilitation of the patients.
Sleep characteristics of middle-aged adults with non-alcoholic fatty liver disease: findings from the Shahrekord PERSIAN Cohort Study
Authors: Zarean Elaheh , Looha Mehdi Azizmohammad , Amini Payam , Ahmadi Ali , Dugué Pierre-Antoine 
Published: June 2022

Abstract
Background: Several studies have reported short sleep duration in people with non-alcoholic fatty liver disease (NAFLD) but other sleep characteristics have been less studied. We aimed to assess the association of NAFLD with sleep duration and quality in an Iranian population sample. Methods: We used data from 9,151 participants in the Shahrekord Prospective Epidemiological Research Studies in Iran (PERSIAN) Cohort Study, including 1,320 diagnosed with NAFLD. Log-binomial regression models sequentially adjusted for sociodemographic, lifestyle, clinical and biological variables were used to estimate relative risks (RR) and 95% confidence intervals (95% CI) for the association between NAFLD and sleep characteristics. Results: Participants with NAFLD had shorter sleep duration, later wake-up time and bedtime, worse sleep efficiency, and more frequent daytime napping and use of sleeping pills, in age- and sex-adjusted models. After controlling for sociodemographic, lifestyle, clinical, and biological variables the associations remained strong for sleep efficiency (per 10%, RR=0.92, 95%CI: 0.88-0.96) and use of sleeping pills (RR=1.48, 95%CI: 1.17-1.88). The association between NAFLD and sleep efficiency was stronger in participants aged >60 years (RR=0.81, 0.70-0.93) and 40-60 years (RR=0.87, 0.82-0.94), compared with those aged <40 years (P-heterogeneity<0.001). Daytime napping in participants with NAFLD was observed in males but not females (P-heterogeneity=0.007), and in those with body mass index (BMI)<30 but not in obese participants (P-heterogeneity<0.001). Conclusions: Diagnosis of NAFLD is associated with several poor sleep characteristics in middle-aged Iranians. Although longitudinal studies would help to clarify the direction of causality, our study shows that poor sleep is an important aspect of NAFLD.
Simultaneous improvement of lodging resistance and grain yield by stacking dep1 with elite genes in rice
Authors: Li Meiru , Pan Xiaoping , Xu Gan , Li Hongqing 
Published: June 2022

Abstract
Lodging-tolerance is one of the most important goals in rice breeding. Due to its semi-dwarfism phenotype, dep1 can potentially improve lodging-tolerance. In this study, dep1 together with other three alleles, gs3, gn1a and ipa1, were integrated into high yield breeding strategy by conventional crossing and four combinations including dep1-gn1a, dep1-gs3, dep1-ipa1, and dep1-gs3-ipa1 were obtained. Though all the combinations showed plant phenotype similar to dep1, such as semi-dwarfism, short dense panicle, and short and erect flag leaf, their 1000-grain weight were observed to increase. Both dep1-ipa1 and dep1-gs3-ipa1 were characterized with improved lodging resistance and high yielding potential, while grain yield in both dep1-gn1a and dep1-gs3 dramatically decreased due to their low seed setting rate. Furthermore, specifically altered expression pattern of auxin and cytokinin related genes and abnormal stigma structure were found in two double mutant lines. Overall, current study demonstrated the potential of pyramiding dep1 conferring lodging-resistant trait with other high-yield related genes in cultivating elite rice varieties and additionally, providing a series of novel core germplasm for new insights into the interplay of dep1, gn1a, gs3, and ipa1 in regulating rice morphogenesis.
Modified marine predators algorithm hybridized with teaching-learning mechanism for solving optimization problems
Authors: Ma Yunpeng , Chang Chang , Lin Zehua , Zhang Xinxin , Song Jiancai , Chen Lei 
Published: June 2022

Abstract
Marine Predators Algorithm (MPA) is a newly nature-inspired meta-heuristic algorithm, which is proposed based on the Lévy flight and Brownian motion of ocean predators. Since the MPA proposed, it has been successfully applied in many fields. However, it exists several shortcomings, such as falling into local optimum easily and precocious convergence. To balance the exploitation and exploration ability of MPA, a modified marine predators algorithm hybridized with teaching-learning mechanism is proposed in this paper, namely MTLMPA. Compared to MPA, the proposed MTLMPA has two highlights. Firstly, a kind of teaching mechanism is introduced in the first phase of MPA to improve the global searching ability. Secondly, a novel learning mechanism is introduced in the third phase of MPA to enhance the chance encounter rate between predator and prey and avoid premature convergence. MTLMPA is verified with 23 benchmark numerical testing functions and CEC-2017 functions. Experiment results reveal that the MTLMPA is competitive compared to the state-of-art heuristic optimization algorithms.
Evaluating of the hydrothermal groundwater flow of El Hamma shallow geothermal aquifer (South-eastern of Tunisia)
Authors: HADDAJI Boulbaba , AGOUBI Belgacem , KARROUBI Adel 
Published: June 2022

Abstract
The area of El Hamma, southeast of Tunisia, is characterized by warm groundwater. The aquifer in the city of El Hamma is considered the main source of water to meet the needs of agricultural, industrial, domestic, and traditional baths. Nowadays, groundwater flow in the aquifer system and the thermal origin have been not well explained. The objective of this study is to develop a conceptual model of the geothermal groundwater flow path based on the temperature distribution in the aquifer in the study area.The groundwater temperature data was collected from 130 wells and implemented into a database. The sampled wells depth range between 25 and 80 m below ground level at temperatures between 18 and 65 degrees Celsius. The temperature remains constant throughout the year, regardless of the external climatic conditions. The variographic analysis and ordinary kriging techniques were used to map the spatial distribution of temperature in the study area. The conceptual model, hydrodynamic, geological, and thermal data confirm a vertical communication between the deep continental intercalary aquifer and the shallow Senonian aquifer through a system of vertical faults, the most important of which are the F1 fault in the west of the region, the F2 near Wadi El Hamma and the F7 towards the east.
Crystal structure thermal evolution and novel orthorhombic phase of methylammonium lead bromide, CH3NH3PbBr3
Authors: Abia Carmen , López Carlos , Cañadillas-Delgado Laura , Fernández-Díaz Maria Teresa , Alonso José Antonio 
Published: June 2022

Abstract
Methylammonium (MA) lead trihalide perovskites, CH3NH3PbX3 (X = I, Br, Cl), have emerged as a new class of light-absorbing materials for photovoltaic applications, reaching efficiencies of 23% when implemented in solar cell heterojunctions. In particular, MAPbBr3 is a promising member with a large bandgap that gives rise to a high open circuit voltage. Here we present a structural study from neutron diffraction (ND) data of an undeuterated MAPbBr3 specimen, carried out to follow its crystallographic behaviour in the 2–298 K temperature range. Besides the known crystallographic phases, i.e. the high-temperature Pm\(\stackrel{-}{3}\)m cubic structure, the intermediate I4/mcm tetragonal symmetry and the low-temperature Pnma orthorhombic phase, we additionally identified, from a detailed sequential ND analysis, a novel intermediate phase within the 148.5–154.0 K temperature range as an orthorhombic Imma structure, early associated with a coexistence of phases. Moreover, our ND data allowed us to unveil the configuration of the organic MA units and their complete localization within the mentioned temperature range, thus improving the crystallographic description of this compound. The evolution with temperature of the H-bonds between the organic molecule and the inorganic cage is also followed. A deep knowledge of the crystal structure and, in particular, the MA conformation inside the perovskite cage seems essential to establish structure-property correlations that may drive further improvements.