bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Reduced Pancreatic Polypeptide Response is Associated With New-onset Pancreatogenic Diabetes Versus Type 2 Diabetes
Authors: Hart Phil A , Kudva Yogish C , Yadav Dhiraj , Andersen Dana K , Li Yisheng , Toledo Frederico G S , Wang Fuchenchu , Bellin Melena D , Bradley David , Brand Randall E , Cusi Kenneth , Fisher William , Mather Kieren , Park Walter G , Saeed Zeb , Considine Robert V , Graham Sarah C , Rinaudo Jo Ann , Serrano Jose , Goodarzi Mark O 
Published: November 2022

Abstract

Purpose
Pancreatogenic diabetes refers to diabetes mellitus (DM) that develops in the setting of a disease of the exocrine pancreas, including pancreatic ductal adenocarcinoma (PDAC) and chronic pancreatitis (CP). We sought to evaluate whether a blunted nutrient response of pancreatic polypeptide (PP) can differentiate these DM subtypes from type 2 DM (T2DM).

Methods
Subjects with new-onset DM (&lt;3 years’ duration) in the setting of PDAC (PDAC-DM, n = 28), CP (CP-DM, n = 38), or T2DM (n = 99) completed a standardized mixed meal tolerance test, then serum PP concentrations were subsequently measured at a central laboratory. Two-way comparisons of PP concentrations between groups were performed using Wilcoxon rank-sum test and analysis of covariance while adjusting for age, sex, and body mass index.

Results
The fasting PP concentration was lower in both the PDAC-DM and CP-DM groups than in the T2DM group (P = 0.03 and &lt;0.01, respectively). The fold change in PP at 15 minutes following meal stimulation was significantly lower in the PDAC-DM (median, 1.869) and CP-DM (1.813) groups compared with T2DM (3.283; P &lt; 0.01 for both comparisons). The area under the curve of PP concentration was significantly lower in both the PDAC-DM and CP-DM groups than in T2DM regardless of the interval used for calculation and remained significant after adjustments.

Conclusions
Fasting PP concentrations and the response to meal stimulation are reduced in new-onset DM associated with PDAC or CP compared with T2DM. These findings support further investigations into the use of PP concentrations to characterize pancreatogenic DM and to understand the pathophysiological role in exocrine pancreatic diseases (NCT03460769).
Cotton, Whiteness, and Other Poisons
Authors: Williams Brian , Porter Jayson Maurice 
Published: November 2022

AbstractThis article examines how racial capitalism has shaped the ecological and technological dynamics of cotton production in the United States South. Cotton’s destructive dependence on chemicals and on the extraction of lives and resources was animated and enabled by anti-Blackness, which sanctioned a systematic hostility to life that encoded environmental violence in plantation landscapes from the seed to the root. Agrotechnological notions of scientific progress and development conceived places, plants, and Black people as interchangeable parts. Tracing these trajectories during slavery and after abolition, the article focuses on two dynamics: the use of chemicals to augment soil fertility and manage cotton’s ecologies, and the deployment of chemicals to protect cotton monocultures. In both instances, the manipulations of cotton’s ecologies and biophysical properties helped maintain plantation profitability and dominance in the face of conjoined crises of political-ecological and racial control. Racialized conceptions of chemical-scientific “innovation,” relations of indebtedness, and notions of threat also siphoned capital gains from Black workers and communities. By converting waste products into fertilizers and poisons, planters and industrialists continued to render Black communities, their labor, and their land as fungible but necessary components in the industrialization of racial capitalism.
“These Lusting, Incestuous, Perverse Creatures”
Authors: Jacobs Joela 
Published: November 2022

AbstractThis article traces the emergence of and shifts in ideas about plant sexuality in European literature from the late seventeenth century to the present, with a particular focus on influential British and a few less well-known German texts. Positioned as a specifically phytopoetic history of plants and sexuality, it demonstrates with the help of literature how plants have been shaping human culture—in this context, the sociocultural norms and understandings of sex, gender, and sexuality. Moving from vegetal visions of virtuous, virginal women-plants and their corruption by pollen and “plant prostitutes” to concerns about “crimes against nature” and the persecution of male same-sex desire, this history ultimately arrives at queer reproduction and pleasure as a collective endeavor.
Theorizing the Gay Frog
Authors: Boast Hannah 
Published: November 2022

AbstractThe gay frog has taken on a surprisingly prominent role in contemporary environmental culture. Primarily associated with American shock jock Alex Jones and the so-called alt-right, fears of frogs being turned gay by hormones in water have nevertheless entered the mainstream, while gay frog memes are shared online by users from across the political spectrum. This article offers a genealogy of the gay frog, situating this recent moment in the longer history of “sex panics” over gay animals described by queer ecologists, and in the context of an ongoing backlash against feminism and trans liberation. It argues that the potency of the gay frog as alt-right symbol derives from the capacity of the frog to instantiate racialized and sexualized anxieties about border crossings. By examining the role of humor in gay frog clips and memes, this article shows how liberal mockery of Jones has inadvertently mainstreamed far-right beliefs and served to consolidate alt-right notions of victimhood. In spite of this, it argues that the comic potential of the gay frog holds promise for queer ecologists seeking to think differently about sex and nature.
Toxic Erotics and Bad Ecosex at Windermere Basin
Authors: Neimanis Astrida 
Published: November 2022

AbstractHow do settler colonialism, control of women’s and differently gendered bodies, sex, industry, pollution—but also pleasure, love, care, desire, bodily autonomy, and survival—cleave together and apart in the inland wetland of Windermere Basin park? Starting with this question, this article explores my own attraction to this tiny place in postindustrial and settler colonial Hamilton, Ontario. I am curious about what it can teach us about the complex entanglements of these things, and the toxic desires that are both enabled and foreclosed by the relations that gather here. In the first section, I briefly rehearse the basin’s toxic history and, guided by Audre Lorde’s definition of erotics and Catriona Sandilands formative work on queer ecologies, my own desirous attachments to the life it nonetheless sustains. The next section reveals how, in the context of settler colonialism and climate catastrophe, these erotics are queerly tangled in questions of more-than-human gender, sex, and reproduction, too, in ways that invite a capacious and multivalent understanding of reproductive justice. The final section examines the performance art of white settler ecosexuals Annie Sprinkle and Beth Stephens, but sets this alongside a performance by Vanessa Dion Fletcher at Windermere, in order to insist on a version of ecosexual erotics that, while joyous, remains imbricated in fraught histories, complicity, and an inalienable attention to what Michif scholar Max Liboiron parses as “differences and obligations.” Taking a cue from settler feminist artist and scholar Lindsay Kelley, I refer to this as “bad ecosex.” In its refusal of purity, bad ecosex holds the trouble of contemporary ecological relations together with the pleasurable power of erotics to build a politics of change grounded in feeling deeply.
Tumor Growth Rate in Spinal Giant Cell Tumors of Bone and Association With the Immune Microenvironment and Denosumab Treatment Responsiveness: A Multicenter Study
Authors: Zheng Bo-Wen , Zheng Bo-Yv , Niu Hua-Qing , Yang Yi-Fan , Zhu Guo-Qiang , Li Jing , Zhang Tao-Lan , Zou Ming-Xiang 
Published: November 2022

BACKGROUND:
Currently, little is known about the prognostic value of tumor growth rate (TGR) in spinal giant cell tumors of bone (GCTB).

OBJECTIVE:
To investigate the correlation of TGR with clinicopathological features, immune microenvironment, prognosis, and response to denosumab treatment of spinal GCTB.

METHODS:
A total of 128 patients with spinal GCTB treated at 5 centers from 2011 to 2021 were included. TGR was assessed by 2 independent neuroradiologists using at least 2 preoperative thin-section magnetic resonance imaging scans at a minimum interval of 2 months. Immunohistochemistry was used to assess tumor-infiltrating lymphocyte subtypes for CD3, CD4, CD8, CD20, PD-1, PD-L1, and Foxp3. Then, these parameters were analyzed for their associations with patient outcomes (progression-free survival and overall survival), clinicopathological features, and denosumab treatment responsiveness.

RESULTS:
High TGR predicted both poor progression-free survival and overall survival (both P < .001). In addition, TGR was associated with postoperative neurological dysfunction (P < .001), Enneking staging (P = .016), denosumab treatment responsiveness (P = .035), and the number of CD3+ (P < .001), PD-1+ (P = .009), PD-L1+ (P < .001), and FoxP3+ tumor-infiltrating lymphocyte (P = .02). Importantly, TGR outperformed the traditional Enneking, Campanacci, and American Joint Committee on Cancer staging systems in predicting the clinical outcomes of spinal GCTB.

CONCLUSION:
These data support the use of TGR as a reliable predictive tool for clinically relevant outcomes and response to denosumab therapy of spinal GCTB, which may be helpful in guiding prognostic risk stratification and therapeutic optimization of patients.
The ULK complex–LRRK1 axis regulates Parkin-mediated mitophagy via Rab7 Ser-72 phosphorylation
Authors: Fujita Keitaro , Kedashiro Shin , Yagi Takuya , Hisamoto Naoki , Matsumoto Kunihiro , Hanafusa Hiroshi 
Published: November 2022

ABSTRACT
Mitophagy, a type of selective autophagy, specifically targets damaged mitochondria. The ULK complex regulates Parkin-mediated mitophagy, but the mechanism through which the ULK complex initiates mitophagosome formation remains unknown. The Rab7 GTPase (herein referring to Rab7a) is a key initiator of mitophagosome formation, and Ser-72 phosphorylation of Rab7 is important for this process. We have previously identified LRRK1 as a protein kinase responsible for Rab7 Ser-72 phosphorylation. In this study, we investigated the role of LRRK1 in mitophagy. We showed that LRRK1 functions downstream of ULK1 and ULK2 in Parkin-mediated mitophagy. Furthermore, we demonstrated that ectopic targeting of active LRRK1 to mitochondria is sufficient to induce the Ser-72 phosphorylation of Rab7, circumventing the requirement for ATG13, a component of the ULK complex. Thus, the ULK complex recruits LRRK1 to mitochondria by interacting with ATG13 to initiate mitophagosome formation. This study highlights the crucial role of the ULK complex–LRRK1 axis in the regulation of Parkin-mediated mitophagy.
The time course of behavioural phase change in the Central American locust Schistocerca piceifrons
Authors: Foquet Bert , Little Drew W. , Medina-Durán Jorge Humberto , Song Hojun 
Published: November 2022

ABSTRACT
Locusts exhibit an extreme form of phenotypic plasticity and can exist as two alternative phenotypes, known as solitarious and gregarious phases. These phases, which can transform from one to another depending on local population density, show distinctly different behavioural characteristics. The proximate mechanisms of behavioural phase polyphenism have been well studied in the desert locust Schistocerca gregaria and the migratory locust Locusta migratoria, and what is known in these species is often treated as a general feature of locusts. However, this approach might be flawed, given that there are approximately 20 locust species that have independently evolved phase polyphenism. Using the Central American locust Schistocerca piceifrons as a study system, we characterised the time course of behavioural phase change using standard locust behavioural assays, using both a logistic regression-based model and analyses of separate behavioural variables. We found that for nymphs of S. piceifrons, solitarisation was a relatively fast, two-step process, but that gregarisation was a much slower process. Additionally, the density of the gregarisation treatment seemed to have no effect on the rate of phase change. These data are at odds with what we know about the time course of behavioural phase change in S. gregaria, suggesting that the mechanisms of locust phase polyphenism in these two species are different and may not be phylogenetically constrained. Our study represents the most in-depth study of behavioural gregarisation and solitarisation in locusts to date.
Kreowanie negatywnego obrazu instytucji religijnych w polskojęzycznej propagandzie radzieckiej okresu międzywojennego (na podstawie czasopisma „Bezbożnik Wojujący”)
Authors: Ławrynow Daria 
Published: November 2022

CREATING A NEGATIVE IMAGE OF RELIGIOUS INSTITUTIONS IN POLISH-LANGUAGE SOVIET PROPAGANDAIN THE INTERWAR PERIOD (BASED ON THE MAGAZINE “BEZBOŻNIK WOJUJĄCY” [“MILITANT ATHEIST”])
The main issue discussed in this article is the negative image of religious institutions present in Polishlanguage propaganda in the interwar period. The research is based on the analysis of Polish-language Soviet magazine “Bezbożnik Wojujący”. It was published in USSR between 1929 and 1935. “Bezbożnik Wojujący” had some language variants (for example Georgian, Latvian, Russian, Ukrainian) and its main goal was anti-religious atheist propaganda among national minority communities. The magazine presented religious institutions as obscurantist, hypocritical, aimed at sabotage, and anti-Soviet. The objects of pejorativization included the Orthodox, Roman and Greek Catholic Churches, but also Protestants, members of locals sects, and certain Church initiatives such as the third order and the rosary circles. In the Soviet propaganda, which was based on Leninism, all religions were alien and hostile for working classes.
Gerd Hentšelʹ: Regionalʹnye osobennosti ispolʹzovaniâ ukrainsko-russkoj smešannoj reči (suržika) i vliânie dialektov: pristavki i predlogi vid / ot
Authors: Палинська Олеся , Хентшель Герд 
Published: November 2022

REGIONAL PROPERTIES IN UKRAINIAN-RUSSIAN MIXED SPEECH (SURZHYK) AND THE INFLUENCE OF DIALECTS: PREFIXES AND PREPOSITIONS VID / OT
Ukrainian surzhyk is a form of mixed Ukrainian-Russian code influenced not only by standard dialects of Ukrainian and Russian, but also by Ukrainian dialects. In the analyses of the kind and intensity of the influence of Ukrainian or Russian on surzhyk, particularly problematic are the cases in which a given structural phenomenon occurs in some Ukrainian dialects and in the standard language, while in other dialects it is identical or very similar to the phenomenon occurring in Russian. Examples of such language units include the prefixes and vid / ot prepositions discussed in this article. Based on the corpus material, in this study the authors used quantitative methods to present the possibility to differentiate the basic tendencies that determine the way and scope of dialectal influences and both standard languages (Ukrainian and Russian). The main conclusion from the analyses of this linguistic phenomenon is the observation according to which a variant originating from the standard Ukrainian language is only preserved in those areas of using surzhyk in which only such variant occurs. In the regions in which both variants occur dialectally, or only the variant identical to Russian occurs, the latter is preserved. In general, it means that in Ukrainian-language areas variants of synonymical forms are reduced in the process of dialect-levelling in surzhyk as a mezolect.
Abortion incidence and service availability in the United States, 2020
Authors: Jones Rachel K. , Kirstein Marielle , Philbin Jesse 
Published: November 2022

AbstractBackgroundThis study provides a baseline assessment of abortion incidence and service delivery prior to Roe v. Wade being overturned.MethodsWe collected information from all facilities known to have provided abortion services in the United States in 2019 and 2020. We examined abortion incidence by state, region and nationally and combined data on number of abortions with population data to estimate abortion rates. We also examined the number of abortion clinics, trends in medication abortion and service disruptions and changes in abortion protocols that occurred during the COVID‐19 pandemic. We compare these findings to those of our prior Abortion Provider Census, which collected information for 2017.ResultsWe documented 930,160 abortions in 2020, an 8% increase from 2017. Between 2017 and 2020, abortion incidence increased in all four regions of the country and in a majority of states. The total number of clinics providing abortion care remained stable nationally but increased in the Midwest and the West and declined in the Northeast and South. There were 492,210 medication abortions in 2020, a 45% increase from 2017. A substantial minority of clinics adjusted protocols in response to COVID, most commonly adopting remote pre‐ and post‐abortion counseling.DiscussionThis study did not address factors behind the increase in abortion. However, this report demonstrates that the need for abortion care was growing just prior to the overturning Roe v. Wade, and the impact of this decision will be even more far‐reaching than previously expected.
Spatial multiplexing and optical PAM4 quadruple the date rate in optical fiber systems
Authors: Su Ce , Chowdhury Bilas , Harish Swaroopini , Tu Mingxuan , Murshid Syed 
Published: November 2022

This endeavor demonstrates a two-channel spatial division multiplexed
(SDM) system and combines it with an all-optical
four-level pulse amplitude modulation (PAM4) scheme to quadruple the
data rate and presents the experimental setup, system model, as well
as key results. The system initially introduces spatial reuse of
optical frequencies in a single-core multimode optical fiber by
transmitting two SDM channels, where both operate at 1310 nm.
It then complements the two SDM channels with an all-optical PAM4
scheme to enable 2 bits/symbol and 40 Gbps optical
transport while using only 10 Gbps sources. Since all sources
operate at the same wavelength, it effectively achieves PAM16
efficiencies at the given wavelength. The system accomplishes these
results without the use of dedicated PAM4 chipsets.
Molecular detection and characterisation of the first Japanese encephalitis virus belonging to genotype IV acquired in Australia
Authors: Sikazwe Chisha , Neave Matthew J. , Michie Alice , Mileto Patrick , Wang Jianning , Cooper Natalie , Levy Avram , Imrie Allison , Baird Robert W. , Currie Bart J. , Speers David , Mackenzie John S. , Smith David W. , Williams David T. 
Published: November 2022

Background
A fatal case of Japanese encephalitis (JE) occurred in a resident of the Tiwi Islands, in the Northern Territory of Australia in February 2021, preceding the large JE outbreak in south-eastern Australia in 2022. This study reports the detection, whole genome sequencing and analysis of the virus responsible (designated JEV/Australia/NT_Tiwi Islands/2021).

Methods
Reverse transcription quantitative PCR (RT-qPCR) testing was performed on post-mortem brain specimens using a range of JE virus (JEV)-specific assays. Virus isolation from brain specimens was attempted by inoculation of mosquito and mammalian cells or embryonated chicken eggs. Whole genome sequencing was undertaken using a combination of Illumina next generation sequencing methodologies, including a tiling amplicon approach. Phylogenetic and selection analyses were performed using alignments of the Tiwi Islands JEV genome and envelope (E) protein gene sequences and publicly available JEV sequences.

Results
Virus isolation was unsuccessful and JEV RNA was detected only by RT-qPCR assays capable of detecting all JEV genotypes. Phylogenetic analysis revealed that the Tiwi Islands strain is a divergent member of genotype IV (GIV) and is closely related to the 2022 Australian outbreak virus (99.8% nucleotide identity). The Australian strains share highest levels of nucleotide identity with Indonesian viruses from 2017 and 2019 (96.7–96.8%). The most recent common ancestor of this Australian-Indonesian clade was estimated to have emerged in 2007 (95% HPD range: 1998–2014). Positive selection was detected using two methods (MEME and FEL) at several sites in the E and non-structural protein genes, including a single site in the E protein (S194N) unique to the Australian GIV strains.

Conclusion
This case represents the first detection of GIV JEV acquired in Australia, and only the second confirmed fatal human infection with a GIV JEV strain. The close phylogenetic relationship between the Tiwi Islands strain and recent Indonesian viruses is indicative of the origin of this novel GIV lineage, which we estimate has circulated in the region for several years prior to the Tiwi Islands case.
Effect of exercise and/or educational interventions on physical activity and pain in patients with hip/knee osteoarthritis: A systematic review with meta-analysis
Authors: Sasaki Ryo , Honda Yuichiro , Oga Satoshi , Fukushima Takuya , Tanaka Natsumi , Kajiwara Yasuhiro , Nakagawa Koichi , Takahashi Ayumi , Sakamoto Yukinori , Morita Hinako , Kondo Yutaro , Okita Seima , Kondo Yasutaka , Goto Kyo , Kataoka Hideki , Sakamoto Junya , Okita Minoru 
Published: November 2022

Objective
To investigate the effectiveness of exercise and/or educational intervention on physical activity and pain in patients with hip/knee osteoarthritis (OA) using systematic review and meta-analysis.

Methods
We searched randomized controlled trials that investigated physical activity and pain and compared exercise and/or educational intervention with usual care in patients with hip/knee OA in MEDLINE (PubMed), ProQuest, Scopus, and the Physiotherapy Evidence Database (PEDro), including all those published by April 30, 2022 and written in English. Studies that newly applied analgesics after onset of the intervention were excluded. The revised Cochrane risk-of-bias tool for randomized trials was used to assess the methodological qualities. The random-effects model was used for meta-analysis with standard mean differences using RevMan version 5.4. The body of evidence for each study was synthesized using the Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) approach.

Results
Twenty studies including 2,350 patients were included (7 exercise studies, 8 educational intervention studies and 5 combination studies). The meta-analysis demonstrated that there is very low evidence that combination therapy of exercise and educational intervention improve the physical activity level at the endpoint (4 articles; SMD 0.33, 95% CI 0.04 to 0.51, P = 0.03). Low evidence was observed for combination therapy reducing pain (4 articles; SMD -0.15, 95% CI -0.29 to -0.02, P = 0.03).

Discussion
The current evidence indicated that combination therapy of exercise and educational intervention leads to improved physical activity and pain reduction in hip/knee OA patients, but the risk of bias in each study, especially in allocation concealment, downgraded the evidence level. These findings support the use of a combination therapy of exercise and educational intervention to promote physical activity levels in patients with hip/knee OA.

Trail registration
There was no financial support for this research. The protocol was registered at the International Prospective Register of Systematic Reviews (registration code: CRD42020205804).