bluuebunny/crossref_metadata_2025_split huggingface dataset:
Predicting Intravenous Immunoglobulin Resistance Among North American Children Hospitalized With Kawasaki Disease
Authors: Singh Jasdip , Chang Arthur , Fusco Nicholas M. , Hicar Mark 
Published: September 2022

OBJECTIVE
The Kobayashi score (KS) is the most widely used tool for predicting intravenous immunoglobulin (IVIG) resistance in Kawasaki disease (KD). The KS has shown good sensitivity (86%) and specificity (68%) in Japanese children; however, its use is limited outside of Japan. No models accurately predict IVIG resistance of children with KD in the United States. We sought to develop and test a novel scoring system to predict IVIG resistance in hospitalized children with KD.

METHODS
A retrospective chart review was conducted of all children diagnosed with KD from January 2000 to December 2015. Subjects were divided into 2 groups: IVIG susceptible or resistant. Variables that differed between the groups were identified and used to create a “new score” to predict resistance to IVIG. The new score was then compared with the KS and performance characteristics were determined.

RESULTS
A total of 208 subjects were reviewed. White blood cell count, neutrophil percentage, age, and serum albumin were used in the new score with equal weighting. Overall, the new score achieved improved sensitivity (54% vs 26%) and similar specificity (69% vs 74%) compared with the KS in predicting IVIG resistance in hospitalized children diagnosed with KD.

CONCLUSIONS
Predicting IVIG resistance in children diagnosed with KD remains challenging. The KS has low sensitivity in predicting IVIG resistance in children with KD in the United States. The new score resulted in improved sensitivity, but many children with true IVIG resistance may be missed. Further research is needed to improve IVIG resistance prediction.
Language Features Used by Jeffree Star the Top English Speaker Beauty Vlogger
Authors: Mustika Xarista Eunice Alfanadha 
Published: September 2022

This study aims to find out the women’s and men’s language features used by Jeffree Star in his monologue entitled Full Face of Brands That Hate Me. The theoretical framework was based on Lakoff (2004) and Coates (2004) theories of language features. This study employed a qualitative approach. I found that Jeffree Star used color terms, adjectives, hedges, intonations, grammar, politeness, swear words, commands and directives, and questions. Jeffree Star also used two language features at the same time namely color terms and hedges, grammar and questions, swear words and hedges, and swear words and politeness. The use of language features by Jeffree Star was influenced by the topic of the talk and the gender identity. Further studies involving more subjects, objects, or other socio variables are needed to achieve a better understanding of the use of women’s and men’s language features. Keywords: language features, monologue, beauty vlogger
Increasing the Brand Awareness of Toko Makmur Raya’s Target Market Through a Promotional Video
Authors: Otto Sugiarto Surya 
Published: September 2022

Toko Makmur Raya is a paint shop located in Makassar. The store's target markets are forepersons, house owners, and developers. Those three frequently visit the store and become loyal customers of the store. As one of the biggest stores in Makassar, Toko Makmur Raya has problem. That Toko Makmur Raya does not have strong branding to attract the target market. Therefore, Toko Makmur Raya needs to increase its brand awareness. To make that happen, the author provides a solution which is a promotional video. The theory of branding, target market, Unique Selling Point (USP), promotion, and promotional video will be used to make it happen. After finding out three USPs of the store that is: complete, affordable, and excellent services, those were highlighted in the promotional video. A promotional video can benefit the store because it can reach a larger audience by uploading the video to social platforms. Keywords: promotional video, brand awareness, target market, private store
Superior Room Temperature Compressive Plasticity of Submicron Beta‐Phase Gallium Oxide Single Crystals
Authors: Wu Yueqin , Rao Qijian , Best James P. , Mu Dekui , Xu Xipeng , Huang Han 
Published: September 2022

AbstractBulk‐scale (01)‐oriented monoclinic beta‐phase gallium oxide (β‐Ga2O3) single crystals are brittle and fracture at low compressive strains. Here, it is reported that submicron β‐Ga2O3 pillars exhibit an exceptional room temperature plastic strain of up to ≈22% under compression. Deformation is observed in transition from brittle to superior plasticity with reduction of pillar size. The critical diameter for the brittle to ductile transition is ≈800 nm, attributed to the initiation of dislocation slip on the primary (400) slip planes. Below 500 nm, a second transition is reported to superior plastic deformation, achieved through the activation of secondary mechanisms due to both deconfinement and low crystalline symmetry of β‐Ga2O3, differentiating this finding from size‐effected plasticity of other brittle materials where plasticity is attributed to dislocation slip on primary slip planes. Molecular dynamics simulation supports the proposed mechanism of pillar deconfinement where plastic deformation in larger pillars is solely dominated by planar defects on (400) slip planes, while secondary defects are induced for sufficiently small pillars. No plasticity is observed for equally dimensioned pillars tested on a (010)‐oriented surface, highlighting the importance of presenting crystallography on submicron plasticity in this material.
Interfacial Magnetic Features of La2CoMnO6/Pt Bilayers Studied by Using Spin Hall Magnetoresistance
Authors: Martín‐Rio Sergi , Frontera Carlos , Gómez‐Pérez Juan M. , Aguilar‐Pujol Montserrat X. , Catalano Sara , Gázquez Jaume , Casanova Fèlix , Balcells Lluis , Pomar Alberto , Martinez Benjamin 
Published: September 2022

AbstractSpin Hall magnetoresistance (SMR) is used to study interfacial magnetic features in La2CoMnO6 (LCMO)/Pt bilayers. LCMO is a ferromagnetic insulator with a Curie temperature Tc = 250 K and a strong magnetic anisotropy that can be tuned by microstructural strain. However, SMR measurements do not show any dependence on the strained state of the LCMO films. In addition, contrary to what may be expected, SMR signal persists above TC exhibiting a strong magnetic field dependence well above the saturation of the magnetization while the typical hysteresis on crossing H = 0 is absent. All these results suggest that the uppermost LCMO interfacial layers are magnetically uncoupled from the rest of the LCMO film and they do not show long range magnetic ordering. This fact is confirmed by a complete scanning transmission electron microscopy study of the interface that makes evident that the last atomic layers of the LCMO film do not contain Co and have a LaMnO3+δ simple perovskite‐like structure with the last atomic layer being lanthanum oxide. The analysis of the experimental results according to recent SMR theories indicates, in fact, that the LCMO interfacial layer behaves as a 2D Heisenberg ferromagnet.
Postexposure progression of pneumoconiosis among former Appalachian coal miners
Authors: Hall Noemi B. , Blackley David J. , Markle Travis , Crum James B. , Halldin Cara N. , Laney A. Scott 
Published: September 2022

AbstractBackgroundThe prevalence of pneumoconiosis among working United States underground coal miners has been increasing for the past two decades, with the highest rates of disease observed among miners in the central Appalachian states of Kentucky, Virginia, and West Virginia. Surveillance for this disease in the United States focuses on working coal miners, who continue to be occupationally exposed to dust. This study examines the radiographic evidence for postexposure progression of pneumoconiosis in a population of former coal miners no longer occupationally exposed to coal mine dust who were seen at a community radiology clinic in eastern Kentucky.MethodsData were obtained and analyzed from clinical records of former coal miners who had a clinic encounter during January 1, 2017–August 1, 2019, a recorded final year of employment, and ≥2 postemployment digital chest radiographs. Radiographs were classified according to the International Labour Office guidelines by at least two B Readers. A final summary pneumoconiosis severity score (range, 0–13), accounting for both small and large opacities, was assigned to each chest radiograph. Progression was defined as an increase in severity score between a miner's radiographs over time.ResultsData for 130 former coal miners were analyzed. All miners were male and most (n = 114, 88%) had worked primarily in Kentucky. Information on race/ethnicity was not available. The most common job types were roof bolters (n = 51, 39%) and continuous miner operators (n = 46, 35%). Forty‐one (31.5%) miners had evidence of radiographic disease progression after leaving the workforce, with a median of 3.6 years between first and latest postretirement radiograph. A total of 80 (62%) miners had evidence of pneumoconiosis on their latest radiograph, and two‐thirds (n = 53) of these were classified as progressive massive fibrosis (PMF), the most severe form of the disease.ConclusionsPostexposure progression can occur in former coal miners, emphasizing the potential benefits of continued radiographic follow‐up postemployment. In addition to participating in disease screening throughout their careers to detect pneumoconiosis early and facilitate intervention, radiographic follow‐up of former coal miners can identify new or progressive radiographic findings even after workplace exposure to respirable coal mine dust ends. Identification of progressive pneumoconiosis in former miners has potential implications for clinical management and eligibility for disability compensation.
Cyanine Dye Coupling Mediates Self‐assembly of a pH Sensitive Peptide into Novel 3D Architectures
Authors: Fernandes Rita , Chowdhary Suvrat , Mikula Natalia , Saleh Noureldin , Kanevche Katerina , Berlepsch Hans v. , Hosogi Naoki , Heberle Joachim , Weber Marcus , Böttcher Christoph , Koksch Beate 
Published: September 2022

AbstractSynthetic multichromophore systems are of great importance in artificial light harvesting devices, organic optoelectronics, tumor imaging and therapy. Here, we introduce a promising strategy for the construction of self‐assembled peptide templated dye stacks based on coupling of a de novo designed pH sensitive peptide with a cyanine dye Cy5 at its N‐terminus. Microscopic techniques, in particular cryogenic TEM (cryo‐TEM) and cryo‐electron tomography technique (cryo‐ET), reveal two types of highly ordered three‐dimensional assembly structures on the micrometer scale. Unbranched compact layered rods are observed at pH 7.4 and two‐dimensional membrane‐like assemblies at pH 3.4, both species displaying spectral features of H‐aggregates. Molecular dynamics simulations reveal that the coupling of Cy5 moieties promotes the formation of both ultrastructures, whereas the protonation states of acidic and basic amino acid side chains dictates their ultimate three‐dimensional organization.
Intraligand Charge Transfer Enables Visible‐Light‐Mediated Nickel‐Catalyzed Cross‐Coupling Reactions**
Authors: Cavedon Cristian , Gisbertz Sebastian , Reischauer Susanne , Vogl Sarah , Sperlich Eric , Burke John H. , Wallick Rachel F. , Schrottke Stefanie , Hsu Wei‐Hsin , Anghileri Lucia , Pfeifer Yannik , Richter Noah , Teutloff Christian , Müller‐Werkmeister Henrike , Cambié Dario , Seeberger Peter H. , Vura‐Weis Josh , van der Veen Renske M. , Thomas Arne , Pieber Bartholomäus 
Published: September 2022

AbstractWe demonstrate that several visible‐light‐mediated carbon−heteroatom cross‐coupling reactions can be carried out using a photoactive NiII precatalyst that forms in situ from a nickel salt and a bipyridine ligand decorated with two carbazole groups (Ni(Czbpy)Cl2). The activation of this precatalyst towards cross‐coupling reactions follows a hitherto undisclosed mechanism that is different from previously reported light‐responsive nickel complexes that undergo metal‐to‐ligand charge transfer. Theoretical and spectroscopic investigations revealed that irradiation of Ni(Czbpy)Cl2 with visible light causes an initial intraligand charge transfer event that triggers productive catalysis. Ligand polymerization affords a porous, recyclable organic polymer for heterogeneous nickel catalysis of cross‐coupling reactions. The heterogeneous catalyst shows stable performance in a packed‐bed flow reactor during a week of continuous operation.
A survey across orbital lymphoma in Poland: Multicenter retrospective study of polish lymphoma research group (PLRG)
Authors: Kalicińska Elżbieta , Giza Agnieszka , Zaucha Jan Maciej , Giebel Sebastian , Zimowska‐Curyło Dagmara , Andrasiak Iga , Spychałowicz Wojciech , Wojnar Jerzy , Balcerzak Andrzej , Romejko‐Jarosińska Joanna , Paszkiewicz‐Kozik Ewa , Knopińska‐Posłuszny Wanda , Rybka Justyna , Jabłonowska Paula , Wróbel Tomasz 
Published: September 2022

AbstractObjectiveTo investigate the prevalence of histopathological subtypes, the clinical stage at presentation and treatment modalities in Polish patients with orbital lymphoma (OL) and to determine prognostic outcomes.MethodsThe retrospective study of 107 patients with OL treated in a 14‐year period in Polish hematological centers. The analysis included histopathological subtype, disease clinical advancement, treatment modalities, progression‐free survival (PFS), and overall survival (OS).ResultsThe median patient age was 60 years (range 51–71). Mucosa‐associated lymphoid tissue (MALT) lymphoma accounted for slightly more than half of all cases of orbital lymphoma (51%). The second most common subtype was diffuse large B‐cell lymphoma (DLBCL) (29%). Primary orbital lymphoma was diagnosed in 48% of all patients. According to the Ann Arbor, localized stage IE of orbital lymphoma was diagnosed only in 39% of all patients. Systemic involvement was observed in more than half of all patients (52%). The median follow‐up period was 30 months (range 0–160 months). Patients with non‐MALT lymphoma had a significantly inferior PFS compared to patients with MALT lymphoma, (p = 0.047). Patients with primary orbital lymphoma had a superior PFS compared to patients with secondary orbital lymphoma [median PFS 104.5 months vs. 33.4 months], (p = 0.069).Younger patients with MALT lymphoma were characterized by superior PFS (median PFS not reached) compared to other studied subgroups of patients (older patients with MALT lymphoma, younger and older non‐MALT lymphoma patients) with a median PFS of 30.5, 32.2, 32.6 months respectively (p = 0.039). Patients treated with chemotherapy alone had inferior PFS compared to patients treated with combined therapies (p = 0.034). The median PFS across patients who received chemotherapy alone was 23.7 months, whereas across other patients was 73.9 months.ConclusionsSecondary lymphoma accounts for more than half of the orbital lymphoma in Polish population. The advanced clinical stage of the disease (non‐IE according to Ann Arbor) concerns two‐thirds of the overall population of patients with orbital lymphomas and one‐third of MALT lymphoma patients. The high incidence of advanced stages of orbital lymphoma may indicate the need for combined treatment. Combined orbital lymphoma treatment is associated with superior PFS compared to chemotherapy alone in overall population of patients with orbital lymphoma.
Illuminating Sub‐Cellular Organelles by Small Molecule AIEgens
Authors: Ingle Jaypalsing , Sengupta Poulomi , Basu Sudipta 
Published: September 2022

AbstractSub‐cellular organelles play a critical role in a myriad biological phenomena. Consequently, organelle structures and functions are invariably highjacked in diverse diseases including metabolic disorders, aging, and cancer. Hence, illuminating organelle dynamics is crucial in understanding the diseased states as well as developing organelle‐targeted next generation therapeutics. In this review, we outline the novel small molecules which show remarkable aggregation‐induced emission (AIE) properties due to restriction in intramolecular motion (RIM). We outline the examples of small molecules developed to image organelles like mitochondria, endoplasmic reticulum (ER), Golgi, lysosomes, nucleus, cell membrane and lipid droplets. These AIEgens have tremendous potential for next‐generation phototherapy.
Enaminone Formation Drives the Coupling of Biosynthetic Pathways to Generate Cyclic Lipopeptides
Authors: Candra Hartono , Ma Guang‐Lei , En Sean Lee Qiu , Liang Zhao‐Xun 
Published: September 2022

AbstractA family of novel cyclic lipopeptides named tasikamides A−H (Tsk A−H) were discovered recently in Streptomyces tasikensis P46. Aside from the unique cyclic pentapeptide scaffold shared by the tasikamides, Tsk A−C contain a hydrazone bridge that connects the cyclic pentapeptide to the lipophilic alkyl 5‐hydroxylanthranilate (AHA) moiety. Here we report the production of tasikamides I−K (Tsk I−K) by a mutant strain of S. tasikensis P46 that overexpresses two pathway‐specific transcription regulators. Unlike Tsk A−C, Tsk I−K feature a rare enaminone‐bridge that links the cyclic peptide scaffold to the AHA moiety. Our experimental data suggest that Tsk I−K are generated by the coupling of two biosynthetic pathways via a nonenzymatic condensation reaction between an arylamine and a β‐keto aldehyde‐containing precursor. The results underscore the nucleophilic and electrophilic reactivity of the β‐keto aldehyde moiety and its ability to promote fragment coupling reactions in live microbial cells.
Holistic Analysis of the Tribological Interfaces of an Axial Piston Pump – Focusing on the Pump Efficiency
Authors: Shorbagy Ahmed , Ivantysyn Roman , Weber Jürgen 
Published: September 2022

AbstractResearch work performed on an axial piston pump is shown in a holistic manner, analyzing each lubricating interface by linking their gap height and temperature behavior to the overall pump efficiency. The temperature field and dynamic fluid film height were measured in two of the three lubricating interfaces. This is the first time that the temperature fields and gap heights were simultaneously measured in two of the main three interfaces of an axial piston machine. For a deeper analysis of the measurement data, all gaps were simulated with a numerical tool which takes solid body deformation due to temperature and pressure loads into account. This unique combination of both extensive measurement data and sophisticated simulation resulted in novel trends that clarify the complex phenomena occurring in these hydrostatic fluid films.
Binding of Glycans to the SARS CoV‐2 Spike Protein, an Open Question: NMR Data on Binding Site Localization, Affinity, and Selectivity
Authors: Maass Thorben , Ssebyatika George , Brückner Marlene , Breckwoldt Lea , Krey Thomas , Mallagaray Alvaro , Peters Thomas , Frank Martin , Creutznacher Robert 
Published: September 2022

AbstractWe have used NMR experiments to explore the binding of selected glycans and glycomimetics to the SARS CoV‐2 spike glycoprotein (S‐protein) and to its receptor binding domain (RBD). STD NMR experiments confirm the binding of sialoglycans to the S‐protein of the prototypic Wuhan strain virus and yield dissociation constants in the millimolar range. The absence of STD effects for sialoglycans in the presence of the Omicron/BA.1 S‐protein reflects a loss of binding as a result of S‐protein evolution. Likewise, no STD effects are observed for the deletion mutant Δ143–145 of the Wuhan S‐protein, thus supporting localization of the binding site in the N‐terminal domain (NTD). The glycomimetics Oseltamivir and Zanamivir bind weakly to the S‐protein of both virus strains. Binding of blood group antigens to the Wuhan S‐protein cannot be confirmed by STD NMR. Using 1H,15N TROSY HSQC‐based chemical shift perturbation (CSP) experiments, we excluded binding of any of the ligands studied to the RBD of the Wuhan S‐protein. Our results put reported data on glycan binding into perspective and shed new light on the potential role of glycan‐binding to the S‐protein.
Emergence of Spinmerism for Molecular Spin‐Qubits Generation**
Authors: Roseiro Pablo , Petit Louis , Robert Vincent , Yalouz Saad 
Published: September 2022

AbstractMolecular platforms are regarded as promising candidates in the generation of units of information for quantum computing. Herein, a strategy combining spin‐crossover metal ions and radical ligands is proposed from a model Hamiltonian first restricted to exchange interactions. Unusual spin states structures emerge from the linkage of a singlet/triplet commutable metal centre with two doublet‐radical ligands. The ground state nature is modulated by charge transfers and can exhibit a mixture of triplet and singlet local metal spin states. Besides, the superposition reaches a maximum for, suggesting a necessary competition between the intramolecularand inter‐metal‐ligandanddirect exchange interactions. The results promotespinmerism, an original manifestation of quantum entanglement between the spin states of a metal centre and radical ligands. The study provides insights into spin‐coupled compounds and inspiration for the development of molecular spin‐qubits.
Mechanism of the Early Catalytic Events in the Collagenolysis by Matrix Metalloproteinase‐1
Authors: Waheed Sodiq O. , Varghese Ann , DiCastri Isabella , Kaski Brenden , LaRouche Ciara , Fields Gregg B. , Karabencheva‐Christova Tatyana G. 
Published: September 2022

AbstractMetalloproteinase‐1 (MMP‐1) catalyzed collagen degradation is essential for a wide variety of normal physiological processes, while at the same time contributing to several diseases in humans. Therefore, a comprehensive understanding of this process is of great importance. Although crystallographic and spectroscopic studies provided fundamental information about the structure and function of MMP‐1, the precise mechanism of collagen degradation especially considering the complex and flexible structure of the substrate, remains poorly understood. In addition, how the protein environment dynamically reorganizes at the atomic scale into a catalytically active state capable of collagen hydrolysis remains unknown. In this study, we applied experimentally‐guided multiscale molecular modeling methods including classical molecular dynamics (MD), well‐tempered (WT) classical metadynamics (MetD), combined quantum mechanics/molecular mechanics (QM/MM) MD and QM/MM MetD simulations to explore and characterize the early catalytic events of MMP‐1 collagenolysis. Importantly the study provided a complete atomic and dynamic description of the transition from the open to the closed form of the MMP‐1•THP complex. Notably, the formation of catalytically active Michaelis complex competent for collagen cleavage was characterized. The study identified the changes in the coordination state of the catalytic zinc(II) associated with the conformational transformation and the formation of catalytically productive ES complex. Our results confirm the essential role of the MMP‐1 catalytic domain's α‐helices (hA, hB and hC) and the linker region in the transition to the catalytically competent ES complex. Overall, the results provide unique mechanistic insight into the conformational transformations and associated changes in the coordination state of the catalytic zinc(II) that would be important for the design of effective MMP‐1 inhibitors.