bluuebunny/crossref_metadata_2025_split huggingface dataset:
Long-Term Survival of Hintegra Revision Ankle Arthroplasty in 116 Patients
Authors: Kvarda Peter , Susdorf Roman , Horn-Lang Tamar , Peterhans Ursina , Ruiz Roxa , Hintermann Beat 
Published: November 2022

Category: Ankle; Ankle Arthritis; Hindfoot Introduction/Purpose: Total ankle replacement (TAR) became a popularly utilized surgical solution for end-stage ankle osteoarthritis (OA). Consequent to the increased number of primary implantations, failed ankles are evermore challenge for foot and ankle surgeons. Historically, if the ankle failed, salvage was preferably fusion. Nowadays however, maintenance of the ankle and hindfoot functionality is first and foremost for the expanded patient group. Despite revision arthroplasty has been described as a viable option, the available literature on long-term outcomes is scarce. The aim of this study was to investigate the long-term survival of revision ankle arthroplasty in a uniquely large cohort using the mobile-bearing HINTEGRA prosthesis. Methods: We conducted a single-center retrospective cohort study included 116 patients (117) ankles following revision ankle arthroplasty for failed primary TAR from July 2000 to March 2010. Survival analysis was performed. Clinical outcomes including pain on visual analog scale (VAS), American Foot and Ankle Ankle-Hindfoot Score (AOFAS), ankle range of motion (ROM), and patient`s satisfaction were assessed preoperatively and at the last follow-up. Results: The mean follow-up time from initial revision arthroplasty to the latest follow-up was 15.0+-3.0 years (range 11.2 - 20.5). The cumulative survival of the revised ankles at 5, 10 and 15 years was 81+-4%, 74+-4%, and 70+-4%, respectively. Clinical outcomes including pain on VAS declined from median 6 (0 - 10) to 2 (0 - 10) (p<.0001)), and the AOFAS ankle-hindfoot score improved from 43+-17 to 70+-20 (p<.0001)) from preoperatively to the last follow-up. Conclusion: Despite difficult surgical challenge, revision ankle arthroplasty yields an acceptable survival rate and results on long- term, however lower than primary TAR. Careful preoperative planning is crucial to achieve the desired results. Fusion is may not anymore the state-of-the-art solution for failed ankles. The study provides unique information for foot and ankle surgeons improving patient-care and possibly influence decision-making process.
A Radiographic Analysis of Hallux Valgus Interphalangeus and Biplanar Proximal Phalanx Closing Wedge “MoAkin” Osteotomy in Hallux Rigidus Treated with a Synthetic Cartilage Implant
Authors: Lee Jong Min , Cristofaro Caroline , Kayum Shahin , Khan Ryan , Pinsker Ellie , Halai Mansur , Daniels Timothy R. 
Published: November 2022

Category: Midfoot/Forefoot Introduction/Purpose: 'MoAkin' biplanar proximal phalanx closing wedge osteotomy with dorsal cheilectomy has been described as an effective procedure for treatment of hallux rigidus with hallux valgus interphalangeus (HVI). Its role as an adjunct procedure to first metatarsophalangeal joint hemiarthroplasty using a synthetic cartilage implant has not been well described. The purpose of this radiographic analysis was to examine radiographic changes associated with the MoAkin osteotomy performed in patients who underwent first MTPJ hemiarthroplasty using the Cartiva implant. Methods: A retrospective study of all patients with hallux rigidus and HVI treated with a synthetic cartilage implant and MoAkin osteotomy between 2009 and 2020 was conducted. Radiographs were performed preoperatively and at six- and/or twelve-month postoperatively, and evaluated using standardized measurement techniques. Hallux valgus angle (HVA), interphalangeal angle (IPA), and intermetatarsal angle (IMA) were measured. Results: Fifty-four patients were included in the study (37 male; 17 female). Mean preoperative HVA, IPA, and IMA were 11.7+- 4.2 degrees, 15.8+-4.6 degrees, and 8.2+-2.4 degrees, respectively. Mean six-month postoperative HVA, IMA, IPA were 7.7+-4.2 degrees, 15.7+-5.7 degrees, and 8.2 +- 3.0 degrees. Mean twelve-month postoperative HVA, IMA, IPA were 8.0+-4.5 degrees, 15.2+-6.1 degrees, and 8.1+-2.9 degrees. No statistical differences were found between the six-month and twelve-month radiographic analysis (p>=0.59). There was a statistically significant reduction in the hallux valgus angle at six and twelve-month follow up compared to the preoperative angles (p<0.001, d=0.73-1.16). No statistically significant differences were noted in terms of IPA and IMA (p>=0.31). Conclusion: MoAkin osteotomy improves the hallux valgus angle in patients with hallux rigidus and HVI undergoing first MTPJ hemiarthroplasty with the Cartiva implant. Further studies are warranted to evaluate the impact of these radiographic findings on patient-reported outcomes and other clinical outcomes.
Distribution of Bone Mineral Density in the Ankle Joint: Correlation with Hindfoot Alignment
Authors: Lintz Francois , Welck Matthew J. , Buedts Kristian , Fernando Céline , Netto Cesar de Cesar , Bernasconi Alessio 
Published: November 2022

Category: Ankle; Basic Sciences/Biologics; Hindfoot Introduction/Purpose: Abnormal Hindfoot Alignment (HA) has been correlated with increased complication rates in ankle fusion or replacement. Altered Bone Mineral Density (BMD) due to abnormal stress distribution could be predisposing factor for those unwanted outcomes. The objective of this study was to assess spatial distribution of BMD around the ankle joint in patients with normal or abnormal HA using cone beam Weight Bearing CT. Methods: Retrospective comparative study including 81 ankles allocated into 3 groups based on the Foot Ankle Offset (FAO): 27 normal (0%5%). groups were comparable by age (p=0.967), Body Mass Idex (p=0.669), sex (p=0.820) and side (p=0.708). Semi- automatic segmentation (BoneLogic, Disior) was applied to identify bones. Tibia and talus were digitally compartmented in medial (M) and lateral (L) volumes relative to the median sagittal plane. Mean Hounsfield Unit (HU) value per compartment was used to assess BMD and to calculate the Medial over Lateral HU ratio (M/L-HU). Comparisons among the three groups were performed using one-way ANOVA, Kruskal-Wallis and Chi2 tests. Results: Mean +- standard deviation HU values in the compartments in normal cases were 495.2+-110 (medial tibia), 495.6+- 108.1 (lateral tibia), 368.9+-80.3 (medial talus), 448.2+-90.6 (lateral talus) and 686.7+-120.4 (fibula). Upon comparison of the mean BMD value for each compartment in the three groups, the difference did not achieve statistical significance. Conversely, the tibia HU-M/L ratio (0.88+-0.14 in valgus cases, 0.99 +- 0.08 in normally-aligned cases and 1.04+-0.08 in varus cases) and the talar HU- M/L ratio (0.68+-0.18 in valgus cases, 0.82+-0.08 in normally-aligned cases and 0.96+-0.20 in varus cases) were significantly different in the three groups (p<0.001). Conclusion: We found that the BMD in distal tibia, fibula and the talus varies with hindfoot alignment. The increased HU medio- lateral ratio in varus cases was consistent with a greater medial bone density in the tibia and talus, while the decreased ratio found in valgus cases suggested a more lateral concentration in both bones. This data supports the role of WBCT in analyzing BMD distribution. This method could be clinically useful in ankle OA to evaluate bone quality for such considerations as surgical indications or implant positioning.
Clinical Outcomes of Combined Phacoemulsification With Intraocular Lens Placement and Microincision Vitrectomy in Adult Vitreoretinal Disease
Authors: Muns Sofía M. , Villegas Victor M. , Murray Timothy G. , Latiff Azeema , Gold Aaron S. 
Published: November 2022

Purpose: To evaluate the safety and clinical outcomes of combined phacoemulsification with intraocular lens (IOL) placement and microincision vitrectomy surgery (MIVS) in adult patients with concomitant cataract and vitreoretinal disease. Methods: A consecutive series of patients with comorbid vitreoretinal disease and cataract who had combined phacoemulsification with IOL placement and MIVS was retrospectively analyzed. The main outcome measures were visual acuity (VA) and intraoperative and postoperative complications. Results: The analysis comprised 648 eyes of 611 patients. The median follow-up was 26.9 months (range, 12-60 months). The most common vitreoretinal pathology was intraocular tumor (53%). The best-corrected Snellen VA improved from 20/192 at baseline to 20/46 at the 12-month follow-up. The most frequent intraoperative complication was capsule tear (3.9%). The most common postoperative adverse events after 3 months of follow-up (mean, 24 months) were vitreous hemorrhage (3.2%) and retinal detachment (1.8%). No patient developed endophthalmitis. Conclusions: Combined phacoemulsification with IOL placement and MIVS is a safe, effective technique to manage a broad range of vitreoretinal diseases in patients with significant cataract.
CD206+CD68+ mono-macrophages and serum soluble CD206 level are increased in antineutrophil cytoplasmic antibodies associated glomerulonephritis
Authors: An Xiao-Ning , Wei Zhao-Nan , Xie Yin-Yin , Xu Jing , Shen Yan , Ni Li-Yan , Shi Hao , Shen Ping-Yan , Zhang Wen , Chen Yong-Xi 
Published: November 2022

Abstract
Background
Antineutrophil Cytoplasmic Antibodies (ANCA) associated glomerulonephritis (AGN) is a group of autoimmune diseases and mono-macrophages are involved in its glomerular injuries. In this study, we aim to investigate the role of CD206+ mono-macrophages in AGN.

Methods
27 AGN patients (14 active AGN, 13 remissive AGN) together with healthy controls (n = 9), disease controls (n = 6) and kidney function adjusted controls (n = 9) from Department of Nephrology, Ruijin hospital were recruited. Flow cytometry was used to study proportion of CD206+ cells in peripheral blood. Immunohistochemistry for CD206 staining was performed and CD206 expression was scored in different kidney regions. Serum soluble CD206 (sCD206) was measured by enzyme-linked immunosorbent assay (ELISA). We also generated murine myeloperoxidase (MPO) (muMPO) ANCA by immunizing Mpo−/− mice. Mouse bone marrow-derived macrophages (BMDMs) from wild C57BL/6 mice and peripheral blood mononuclear cell (PBMC) derived macrophages from healthy donors were treated with MPO ANCA with or without its inhibitor AZD5904 to investigate the effects of MPO-ANCA on CD206 expression.

Results
The proportion of peripheral CD206+CD68+ cells in active AGN patients were significantly higher than that in remissive patients (p < 0.001), healthy controls (p < 0.001) and kidney function adjusted controls (p < 0.001). Serum sCD206 level in active AGN patients was higher than that in healthy controls (p < 0.05) and remissive patients (p < 0.01). Immunohistochemistry showed CD206 was highly expressed in different kidney regions including fibrinoid necrosis or crescent formation, glomeruli, periglomerular and tubulointerstitial compartment in active AGN patients in comparison with disease controls. Further studies showed MPO ANCA could induce CD206 expression in BMDMs and PBMC derived macrophages and such effects could be reversed by its inhibitor AZD5904.

Conclusion
ANCA could induce CD206 expression on mono-macrophages and CD206+ mono-macrophages are activated in AGN. CD206 might be involved in the pathogenesis of AAV and may be a potential target for the disease.
Regulatory and effector T cell subsets in tumor-draining lymph nodes of patients with squamous cell carcinoma of head and neck
Authors: Norouzian Marzieh , Mehdipour Fereshteh , Ashraf Mohammad Javad , Khademi Bijan , Ghaderi Abbas 
Published: November 2022

Abstract
Background
A crucial role for the immune system has been proposed in the establishment and progression of head and neck squamous cell carcinoma (HNSCC). In this study, we investigated the cytokine and regulatory profiles of T cells in tumor draining lymph nodes (TDLNs) of patients with HNSCC.

Results
The frequencies of CD4+TNF-α+ and CD4+TNF-αhi negatively were associated with poor prognostic factors such as LN involvement (P = 0.015 and P = 0.019, respectively), stage of the disease (P = 0.032 and P = 0.010, respectively) and tumor size (P = 0.026 and P = 0.032, respectively). Frequencies of CD8+IFN-γ+ and CD8+IFN-γ+ TNF-α+ T cells showed negative relationship with tumor grade (P = 0.035 and P = 0.043, respectively). While, the frequencies of CD4+IL-4+, CD8+IL-10+, CD8+IL-4+T cells were higher in advanced stages of the disease (P = 0.042, P = 0.041 and P = 0.030, respectively) and CD4+IFN-γ+TNF-α−, CD8+IL-4+ and CD8+IFN-γ+TNF-α− T cells were higher in patients with larger tumor size (P = 0.026 and P = 0.032, respectively). Negative associations were found between the frequencies of CD4+CD25+Foxp3+ and CD4+CD25+Foxp3+CD127low/− Treg cells and cancer stage (P = 0.015 and P = 0.059).

Conclusion
This study shed more lights on the changes in immune profile of T cells in TDLNs of HNSCC. Larger tumor size and/or LN involvement were associated with lower frequencies of CD4+TNF-α+, CD8+IFN-γ+ and CD8+IFN-γ+TNF-α+ but higher frequency of CD4+IL-4+ T cells. Moreover, Foxp3+Tregs correlated with good prognostic indicators.
Individual differences among older adults with mild and moderate dementia in social and emotional loneliness and their associations with cognitive and psychological functioning
Authors: Carbone Elena , Piras Federica , Pellegrini Francesca Ferrari , Caffarra Paolo , Borella Erika 
Published: November 2022

Abstract
Background
Loneliness is a major health issue among older adults. The aim of this study was to assess the relationship between loneliness, in its social and emotional facets, and the cognitive (language), and behavioral/psychological functioning as well as quality of life (QoL) in people with mild and moderate dementia, i.e., considering dementia severity as an individual characteristic.

Methods
This cross-sectional study involved 58 people with mild dementia and 55 people with moderate dementia. Participants completed the Social and Emotional Loneliness scale, along with measures assessing their language skills, the frequency and severity of their behavioral and psychological symptoms, and their QoL.

Results
Socio-demographic characteristics and depression, but not loneliness or its social and emotional facets, contributed to explain participants’ behavioral and psychological symptoms, regardless of dementia severity. Loneliness explained, though to a small extent (8% of variance), language skills in people with moderate dementia, with social loneliness only accounting for language skills (18% of variance) in this group. Loneliness also modestly accounted for dysphoria symptoms in both the mildly and moderately impaired (6% and 5% of variance, respectively) individuals with social loneliness predicting dysphoric mood in the former group only (7% of variance). Loneliness also explained, to a larger extent, QoL in both the mildly impaired and moderately impaired individuals (27% and 20% of variance, respectively), its social facet predicting QoL in the mildly impaired (30% of variance), and its emotional facet in the moderately impaired (21% of variance) group.

Conclusion
These findings suggest that loneliness and its facets have a clear impact on perceived QoL, and influence the language skills and dysphoria symptoms of people with dementia, to a degree that depends on dementia severity. The assessment of loneliness and its facets in people with dementia considering dementia severity, and the promotion of social inclusion to reduce it should be considered by professionals.
Dominantly inherited myosin IIa myopathy caused by aberrant splicing of MYH2
Authors: Hedberg-Oldfors Carola , Elíasdóttir Ólöf , Geijer Mats , Lindberg Christopher , Oldfors Anders 
Published: November 2022

Abstract
Background
Myosin heavy chain (MyHC) isoforms define the three major muscle fiber types in human extremity muscles. Slow beta/cardiac MyHC (MYH7) is expressed in type 1 muscle fibers. MyHC IIa (MYH2) and MyHC IIx (MYH1) are expressed in type 2A and 2B fibers, respectively. Whereas recessive MyHC IIa myopathy has been described in many cases, myopathy caused by dominant MYH2 variants is rare and has been described with clinical manifestations and muscle pathology in only one family and two sporadic cases.

Methods
We investigated three patients from one family with a dominantly inherited myopathy by clinical investigation, whole-genome sequencing, muscle biopsy, and magnetic resonance imaging (MRI).

Results
Three siblings, one woman and two men now 54, 56 and 66 years old, had experienced muscle weakness initially affecting the lower limbs from young adulthood. They have now generalized proximal muscle weakness affecting ambulation, but no ophthalmoplegia. Whole-genome sequencing identified a heterozygous MYH2 variant, segregating with the disease in the three affected individuals: c.5673 + 1G > C. Analysis of cDNA confirmed the predicted splicing defect with skipping of exon 39 and loss of residues 1860–1891 in the distal tail of the MyHC IIa, largely overlapping with the filament assembly region (aa1877–1905). Muscle biopsy in two of the affected individuals showed prominent type 1 muscle fiber predominance with only a few very small, scattered type 2A fibers and no type 2B fibers. The small type 2A fibers were frequently hybrid fibers with either slow MyHC or embryonic MyHC expression. The type 1 fibers showed variation in fiber size, internal nuclei and some structural alterations. There was fatty infiltration, which was also demonstrated by MRI.

Conclusion
Dominantly inherited MyHC IIa myopathy due to a splice defect causing loss of amino acids 1860–1891 in the distal tail of the MyHC IIa protein including part of the assembly competence domain. The myopathy is manifesting with slowly progressive muscle weakness without overt ophthalmoplegia and markedly reduced number and size of type 2 fibers.
Reversible Pisa syndrome caused by chronic subdural hematoma in a patient with Parkinson’s disease: a case report
Authors: Igami Eriko , Fujimaki Motoki , Shimizu Mai , Ishiguro Yuta , Kodama Takuma , Okuma Yasuyuki , Hattori Nobutaka , Noda Kazuyuki 
Published: November 2022

Abstract
Background
Pisa syndrome (PS), characterized by lateral trunk flexion, is quite common in patients with Parkinson’s disease (PD). Patients with PS are older and have a significantly longer disease duration, more severe motor phenotype, ongoing combined treatment with levodopa and dopamine agonists, and higher levodopa equivalent daily dose. We describe here, to the best of our knowledge, the first case of a woman with PD who developed acute-onset PS caused by chronic subdural hematoma (CSDH).

Case presentation
A 70-year-old woman developed acute-onset lateral flexion of her trunk to the left side while standing, and she was admitted to our hospital. One month before, she had a mild head trauma with loss of consciousness. At 65 years of age, she noticed difficulty with walking and clumsiness with her hands. She was diagnosed as having PD (Hoehn and Yahr stage 2) and levodopa was initiated. Her symptoms were markedly improved. At 67 years of age, she developed orthostatic hypotension and was treated sequentially with fluids, compression stockings, and midodrine. Urgently performed brain computed tomography (CT) showed a CSDH in the right hemisphere resulting in a marked compression of the hemisphere. After surgical evacuation, her PS disappeared. She has fully recovered to her preoperative level of function.

Conclusion
The present case provides a valuable insight, that is, the mesial frontal lobe and its connections from the posterior parietal cortex play crucial roles in maintaining the body schema and in the pathophysiology of PS. This case suggests that CSDH should be considered when clinicians examine acute-onset PS, even in patients with neurodegenerative disorders such as PD. Appropriate patient triage and timely neurosurgical intervention should be considered.
Clinicopathological features of patients with wide local excision of eyelid malignant neoplasms: a more than five years retrospective study from China
Authors: Han Yuanyuan , Kong Miao , Luo Yan , Sun Bin , Wang Zhiqiang , Zhang Hong 
Published: November 2022

AbstractBackgroundTo investigate the correlation between the clinical and pathological characteristics and outcomes in patients with eyelid malignant tumors underwent wide local excision.MethodsThis retrospective study included 141 cases of eyelid malignant neoplasms from January 2010 to December 2015 in Shanxi eye hospital. Demographic and clinical information were collected. The Kaplan–Meier method was used to calculate survival curves, and the log-rank test method was used to compare survival between groups. Cox proportional regression models were used to calculate the hazard ratios (HR) of total recurrence rate and metastasis rate.ResultsOverall, there were 141 eyelid malignant neoplasms cases aged 65.34 ± 9.69 (range, 41—88) years old. The duration time range was from 1 to 828 (61.09 ± 122.21) months. Basal cell carcinoma (BCC) is the most common of all eyelid malignancies, accounting for 84 (59.5%), followed by Sebaceous gland carcinoma (SGC, 41, 29%), Squamous Cell Carcinoma (SCC, 11, 7.8%), Malignant Melanoma (MM, 3, 2.1%)。On cox-regression analysis, pathological classification (HR 1.959; 95% CI 1.012–3.790;p = 0.046) and eyelid tumor surgery history (HR 17.168; 95% CI 1.889–156.011;p = 0.012) were independently associated with recurrence in patients with eyelid malignant neoplasm. Pathological classification (HR 2.177; 95% CI 1.423 -3.331;p < 0.001) was independently associated with metastasis in patients with eyelid malignant neoplasm. Recurrence and metastasis were most likely to occur in 3 years after surgery.ConclusionWide local excision is an effective and economical treatment for eyelid malignant neoplasms. The prognosis is mainly related to pathological types, eyelid tumor surgical history and TNM stages.
ADHD in adults with major depressive or bipolar disorder: does it affect clinical features, comorbidity, quality of life, and global functioning?
Authors: Sadeghian Nadooshan Mohammad Reza , Shahrivar Zahra , Mahmoudi Gharaie Javad , Salehi Leyla 
Published: November 2022

Abstract
Background
This study compared clinical characteristics, concurrent disorders, level of function, and quality of life in adults with bipolar (BD) or major depressive disorder (MDD) in those with/without adult attention defici1t hyperactivity disorder (AADHD).

Methods
The participants were recruited among adult inpatients and outpatients with MDD or BD in their current partial remission in a psychiatric hospital. They were evaluated using the interview for adults with ADHD (DIVA-5), Conners’ Adult ADHD Rating Scales–Self-Report-Screening Version (CAARS-SR-SV), Structured Clinical Interview for DSM-V (SCID-5), Beck Depression Inventory-II and Young Mania Rating Scale, Global Assessment of Functioning (GAF) and World Health Organization Quality of Life Scale-Brief (WHOQoL-BREF).

Results
In those with MDD (n = 105) and BD (n = 103), AADHD was detected as 13.3% and 16.5%, respectively. The inattentive presentation was the most prevalent type among patients with AADHD. Compared to the patients without AADHD, the results regarding the prevalence of comorbidities, suicidal attempts, severity of affective episodes, the early emergence of the affective disorders, and level of quality of life and global functioning were poorer in the group with AADHD (p < 0.05).

Limitations
The participants were individuals with major depressive or bipolar type I disorder with a mostly manic episode, chosen among the referrals to a tertiary psychiatric hospital with high comorbidity and more severe psychopathology. This may limit the generalizability of the findings.

Conclusion
ADHD was common in adults with MDD and BD, along with high psychiatric comorbidity and negative consequences. Clinicians are suggested to screen adults with mood disorders for the symptoms of ADHD for a more precise and comprehensive diagnosis and to provide a more appropriate therapeutic intervention.