bluuebunny/crossref_metadata_2025_split huggingface dataset:
Inhaled turmerones can be incorporated in the organs via pathways different from oral administration and can affect weight-gain of mice
Authors: Takemoto Yuki , Kishi Chihiro , Ehira Hinano , Matsui Nobutaka , Yamaguchi Taichi , Yoshioka Yuri , Matsumura Shinichi , Moriyama Tatsuya , Zaima Nobuhiro 
Published: June 2022

AbstractTurmerones (α-turmerone, β-turmerone, and ar-turmerone) are the major volatile compounds in turmeric (Curcuma longa), a perennial herb of the ginger family. We previously reported that inhaled volatile turmerones could be transferred in the blood and organs. However, the difference between the two pathways, oral administration and inhalation, and the effect of inhaled turmerones on biological activities remain unknown. In this study, we compared the distribution patterns of turmerones after oral administration and inhalation. The relative levels (concentrations of turmerones in each organ/serum) in the lung, olfactory bulb, brain, heart, kidney, and epididymal fat in the inhalation group tended to be, or are significantly, higher than in the oral administration group. The relative levels of brown adipose tissue in the inhalation group were lower than in the oral administration group. Long-term (50 days) inhalation to volatile turmerones suppressed weight gain and hypertrophy of adipocytes in the epididymal fat of mice fed a high-fat diet. These results suggest that inhaled turmerones can be incorporated into the organs of mice via different pathway from as to those from oral administration and can affect the biological function of the organs under certain conditions.
Artemisinin inhibits neutrophil and macrophage chemotaxis, cytokine production and NET release
Authors: Morad Hassan O. J. , Luqman Suaib , Pinto Larissa Garcia , Cunningham Kevin P. , Vilar Bruno , Clayton Georgia , Shankar-Hari Manu , McNaughton Peter A. 
Published: June 2022

AbstractImmune cell chemotaxis to the sites of pathogen invasion is critical for fighting infection, but in life-threatening conditions such as sepsis and Covid-19, excess activation of the innate immune system is thought to cause a damaging invasion of immune cells into tissues and a consequent excessive release of cytokines, chemokines and neutrophil extracellular traps (NETs). In these circumstances, tempering excessive activation of the innate immune system may, paradoxically, promote recovery. Here we identify the antimalarial compound artemisinin as a potent and selective inhibitor of neutrophil and macrophage chemotaxis induced by a range of chemotactic agents. Artemisinin released calcium from intracellular stores in a similar way to thapsigargin, a known inhibitor of the Sarco/Endoplasmic Reticulum Calcium ATPase pump (SERCA), but unlike thapsigargin, artemisinin blocks only the SERCA3 isoform. Inhibition of SERCA3 by artemisinin was irreversible and was inhibited by iron chelation, suggesting iron-catalysed alkylation of a specific cysteine residue in SERCA3 as the mechanism by which artemisinin inhibits neutrophil motility. In murine infection models, artemisinin potently suppressed neutrophil invasion into both peritoneum and lung in vivo and inhibited the release of cytokines/chemokines and NETs. This work suggests that artemisinin may have value as a therapy in conditions such as sepsis and Covid-19 in which over-activation of the innate immune system causes tissue injury that can lead to death.
Neighborhood disadvantage and biological aging biomarkers among breast cancer patients
Authors: Shen Jie , Fuemmeler Bernard F. , Sheppard Vanessa B. , Bear Harry D. , Song Renduo , Chow Wong-Ho , Zhao Hua 
Published: June 2022

AbstractLiving in a disadvantaged neighborhood is associated with adverse clinical outcomes among breast cancer patients, but the underlying pathway is still unclear. Limited evidence has suggested that accelerated biological aging may play an important role. In this study, using a sub-sample of 906 women with newly diagnosed breast cancer at M.D. Anderson, we examined whether levels of selected markers of biological aging (e.g., allostatic load, telomere length, and global DNA methylation) were affected by neighborhood disadvantage. The Area Deprivation Index was used to determine the neighborhood disadvantage. Based on the median ADI at the national level, the study population was divided into low and high ADI groups. Overall, breast cancer patients from the high ADI group were more likely to be younger and non-Hispanic Black than those from the low ADI group (P < 0.001, respectively). They were also more likely to have higher grade and poorly differentiated breast tumors (P = 0.029 and 0.019, respectively). For the relationship with markers, compared to the low ADI group, high ADI group had higher median levels of allostatic load (P = 0.046) and lower median levels of global DNA methylation (P < 0.001). Compared to their counterparts, those from the high ADI group were 20% more likely to have increased allostatic load and 51% less likely to have increased levels of global DNA methylation. In summary, we observed that levels of allostatic load and global DNA methylation are influenced by neighborhood disadvantage among breast cancer patients.
Interannual variability of internal tides in the Andaman Sea: an effect of Indian Ocean Dipole
Authors: Yadidya B. , Rao A. D. 
Published: June 2022

AbstractA marginal sea in the north eastern Indian Ocean, the Andaman Sea, has been known for the presence of high-amplitude internal waves since the nineteenth century. In this study, we explored the interannual variations of the internal wave activity in this complex region. We found that the Dipole Mode Index, which represents the Indian Ocean Dipole (IOD), influences the circulation in the Andaman Sea, which in turn impacts its density stratification on interannual scales. Ocean Reanalysis System 5 data (1993–2018) is used to see an increasing trend in the sub-surface stratification, whereas it showed a decreasing trend in the near-surface waters. Numerical model simulations carried out from 2009 to 2018 have shown that the interannual variability in the generation of semidiurnal internal tides is governed by distinct parameters (tidal forcing and stratification) at different sites in different months. Enhanced upwelling (downwelling) is observed during positive (negative) IOD events. Sensitivity experiments conducted between extreme IOD events (2006 and 2016) revealed an increase in internal tide generation from positive IOD to negative IOD. Furthermore, a sharp decrease in local baroclinic dissipation is seen during negative IOD, increasing baroclinic flux into the Andaman Sea. An increase in the strength of positive IOD could lead to enhanced diapycnal mixing due to strong local dissipation, whereas an increase in the intensity of negative IOD could result in amplified propagation of internal waves.
Sensitivity enhancement in magnetic sensor using CoFeB/Y3Fe5O12 resonator
Authors: Sarker Md Shamim , Yamahara Hiroyasu , Yao Lihao , Tang Siyi , Liao Zhiqiang , Seki Munetoshi , Tabata Hitoshi 
Published: June 2022

AbstractMagnonics, an emerging research field that uses the quanta of spin waves as data carriers, has a potential to dominate the post-CMOS era owing to its intrinsic property of ultra-low power operation. Spin waves can be manipulated by a wide range of parameters; thus, they are suitable for sensing applications in a wide range of physical fields. In this study, we designed a highly sensitive, simple structure, and ultra-low power magnetic sensor using a simple CoFeB/Y3Fe5O12 bilayer structure. We demonstrated that the CoFeB/Y3Fe5O12 bilayer structure can create a sharp rejection band in its spin-wave transmission spectra. The lowest point of this strong rejection band allows the detection of a small frequency shift owing to the external magnetic field variation. Experimental observations revealed that such a bilayer magnetic sensor exhibits 20 MHz frequency shifts upon the application of an external magnetic field of 0.5 mT. Considering the lowest full width half maximum, which is about 2 MHz, a sensitivity of 10–2 mT order can be experimentally achieved. Furthermore, the higher sensitivity in the order of 10–6 T (µT) has been demonstrated using the sharp edge of the rejection band of the CoFeB/Y3Fe5O12 bilayer device. A Y-shaped spin waves interference device with two input arms consisting of CoFeB/Y3Fe5O12 and Y3Fe5O12 has been theoretically investigated. We proposed that such a structure can demonstrate a magnetic sensitivity in the range of $${10}^{-9}$$

10

-
9

T (nT) at room temperature. The sensitivity of the sensor can be further enhanced by tuning the width of the CoFeB metal stripe.
Retinal ganglion cell analysis in patients with sellar and suprasellar tumors with sagittal bending of the optic nerve
Authors: Shinohara Yoichiro , Todokoro Daisuke , Yamaguchi Rei , Tosaka Masahiko , Yoshimoto Yuhei , Akiyama Hideo 
Published: June 2022

AbstractThe study investigated clinical features of sellar and suprasellar tumors with optic nerve bending. Twenty-five patients (13 men/12 women; age, 59.0 ± 12.9 years) with optic nerve bending in one eye who underwent tumor resection for sellar and suprasellar tumors were included. The other eye, without optic nerve bending, was the control. The pre- and postoperative best-corrected visual acuity (BCVA) and ganglion cell layer (GCL) + inner plexiform layer (IPL) thickness were studied retrospectively using optical coherence tomography. Preoperative BCVA in the eye with optic nerve bending was significantly poor and improved significantly after tumor resection. Eyes with optic nerve bending had significantly less GCL + IPL thickness on the temporal side than eyes without optic nerve bending. Preoperative GCL + IPL thickness of the entire macula was reduced in eyes with optic nerve bending and poor postoperative BCVA compared to those with good postoperative BCVA. There was no significant difference in GCL + IPL thickness of eyes with optic nerve bending before and after tumor resection. Optic nerve bending caused by sellar and suprasellar tumors resulted in visual impairment and decreased retinal ganglion cells. Eyes with optic nerve bending and severely reduced GCL + IPL thickness may have less BCVA improvement after tumor resection.
Characterization of nanofluids using multifractal analysis of a liquid droplet trace
Authors: Augustyniak J. , Zgłobicka I. , Kurzydłowski K. , Misiak P. , Wilczewska A. Z. , Gluch Jürgen , Liao Zhongquan , Perkowski D. M. 
Published: June 2022

AbstractThe article presents an innovative approach to the analysis of nanofluids using a nonlinear multifractal algorithm. The conducted research concerned nanofluids prepared from SiO2 nanoparticles (~ 0.01 g) suspended in 100 ml of demineralized water and in 100 ml of 99.5% isopropanol. Subsequently, the nanofluids were subjected to conventional characterization methods such as: determination of the contact angle, determination of zeta potential, pH, and particle size analysis. The obtained results show that the prepared nanofluid is stable in terms of agglomeration over time (nanofluid suspension) and properly prepared in terms of dissolving and dispersing powder particles. The authors, analyzing the results of the presented methods for characterizing nanofluids, proposed a multifractal analysis, which allows detailed local descriptions of complex scaling behaviour, using a spectrum of singularity exponents. Nonlinear analyzes show that the use of multifractal algorithm for nanofluids can improve the process of fluid quality analysis and its preparation based on the multifractal spectrum.
Comparative analysis of OCT-defined parapapillary beta and gamma zones between primary open angle glaucoma and primary angle closure glaucoma
Authors: Shang Kunte , Zhuang Dongli , Dai Yi 
Published: June 2022

AbstractThe ophthalmoscopic beta zone of parapapillary atrophy has recently been proposed to divide into a gamma zone and a (new) beta zone based on OCT imaging. The present study was undertaken to compare the microstructural characteristics of parapapillary gamma and beta zones and their influencing factors between primary open angle glaucoma (POAG) and primary angle closure glaucoma (PACG). Seventy-three PACG patients that had no evidence of an acute attack and 78 POAG patients were enrolled. Patients were matched by propensity scores for age and visual field mean defect (MD) value. The area and angular extent of both zones were measured. In multivariate analysis, a larger beta zone was correlated with older age, severe MD value and longer axial length. A larger gamma zone was correlated with longer axial length. Older age and severe MD value were correlated with the concentric shape of beta zone. Comparing the PACG and POAG groups that adjusted for age and MD value, gamma zone was larger and more prevalent in the POAG group, while beta zone showed no significant difference. Taken separately, MD value was associated with the area and shape of beta zone in the PACG group. Axial length was associated with the temporal shape of beta zone in the POAG group. These data indicated that OCT-defined parapapillary beta and gamma zones exhibited different characteristics in two types of glaucoma. Clinically, the size of parapapillary beta zone may serve as a better indicator of glaucoma severity in eyes with PACG than that in POAG.
eDNA metabarcoding as a promising conservation tool to monitor fish diversity in Beijing water systems compared with ground cages
Authors: Shen Mei , Xiao Nengwen , Zhao Ziyi , Guo Ningning , Luo Zunlan , Sun Guang , Li Junsheng 
Published: June 2022

AbstractFish diversity, an important indicator of the health of aquatic ecosystems, is declining sharply due to water pollution, overfishing, climate change, and species invasion. For protecting fish diversity, effective surveying and monitoring are prerequisites. In this study, eDNA (environmental DNA) metabarcoding and ground cages were used to survey the fish diversity of the Chaobai and Beiyun Rivers in Beijing. Based on the two methods, we identified 40 species, belonging to 35 genera, 18 families, and six orders. The richness of fish identified by eDNA metabarcoding was significantly higher than that captured by ground cages in both rivers. The fish captured by the ground cage method were all recognized by eDNA metabarcoding, except Squalidus wolterstorffi and Saurogobio dabryi, which were captured only in ground cages. The correlation of relative abundance between the two methods was affected by the properties of the rivers, such as the flow rate. Fish caught by ground cage in the Beiyun River were identified by eDNA, but not in the Chaobai River. Our results also suggest that the Chaobai River has higher fish diversity than the Beiyun River and different community assemblage. In addition to differences in the natural properties of the focal rivers, the development of urbanization is also an important contributor to different community structures overserved. eDNA metabarcoding as a new survey tool has great application prospects, it provides certain theoretical data and methodological references for the protection and management of river fish diversity.
Disentangling drivers of air pollutant and health risk changes during the COVID-19 lockdown in China
Authors: Shen Fuzhen , Hegglin Michaela I. , Luo Yuanfei , Yuan Yue , Wang Bing , Flemming Johannes , Wang Junfeng , Zhang Yunjiang , Chen Mindong , Yang Qiang , Ge Xinlei 
Published: June 2022

AbstractThe COVID-19 restrictions in 2020 have led to distinct variations in NO2and O3concentrations in China. Here, the different drivers of anthropogenic emission changes, including the effects of the Chinese New Year (CNY), China’s 2018–2020 Clean Air Plan (CAP), and the COVID-19 lockdown and their impact on NO2and O3are isolated by using a combined model-measurement approach. In addition, the contribution of prevailing meteorological conditions to the concentration changes was evaluated by applying a machine-learning method. The resulting impact on the multi-pollutant Health-based Air Quality Index (HAQI) is quantified. The results show that the CNY reduces NO2concentrations on average by 26.7% each year, while the COVID-lockdown measures have led to an additional 11.6% reduction in 2020, and the CAP over 2018–2020 to a reduction in NO2by 15.7%. On the other hand, meteorological conditions from 23 January to March 7, 2020 led to increase in NO2of 7.8%. Neglecting the CAP and meteorological drivers thus leads to an overestimate and underestimate of the effect of the COVID-lockdown on NO2reductions, respectively. For O3the opposite behavior is found, with changes of +23.3%, +21.0%, +4.9%, and −0.9% for CNY, COVID-lockdown, CAP, and meteorology effects, respectively. The total effects of these drivers show a drastic reduction in multi-air pollutant-related health risk across China, with meteorology affecting particularly the Northeast of China adversely. Importantly, the CAP’s contribution highlights the effectiveness of the Chinese government’s air-quality regulations on NO2reduction.
Deciphering associations between three RNA splicing-related genetic variants and lung cancer risk
Authors: Yang Wenjun , Liu Hongliang , Zhang Ruoxin , Freedman Jennifer A. , Han Younghun , Hung Rayjean J. , Brhane Yonathan , McLaughlin John , Brennan Paul , Bickeboeller Heike , Rosenberger Albert , Houlston Richard S. , Caporaso Neil E. , Landi Maria Teresa , Brueske Irene , Risch Angela , Christiani David C. , Amos Christopher I. , Chen Xiaoxin , Patierno Steven R. , Wei Qingyi 
Published: June 2022

AbstractLimited efforts have been made in assessing the effect of genome-wide profiling of RNA splicing-related variation on lung cancer risk. In the present study, we first identified RNA splicing-related genetic variants linked to lung cancer in a genome-wide profiling analysis and then conducted a two-stage (discovery and replication) association study in populations of European ancestry. Discovery and validation were conducted sequentially with a total of 29,266 cases and 56,450 controls from both the Transdisciplinary Research in Cancer of the Lung and the International Lung Cancer Consortium as well as the OncoArray database. For those variants identified as significant in the two datasets, we further performed stratified analyses by smoking status and histological type and investigated their effects on gene expression and potential regulatory mechanisms. We identified three genetic variants significantly associated with lung cancer risk: rs329118 inJADE2(P = 8.80E−09), rs2285521 inGGA2(P = 4.43E−08), and rs198459 inMYRF(P = 1.60E−06). The combined effects of all three SNPs were more evident in lung squamous cell carcinomas (P = 1.81E−08,P = 6.21E−08, andP = 7.93E−04, respectively) than in lung adenocarcinomas and in ever smokers (P = 9.80E−05,P = 2.70E−04, andP = 2.90E−05, respectively) than in never smokers. Gene expression quantitative trait analysis suggested a role for the SNPs in regulating transcriptional expression of the corresponding target genes. In conclusion, we report that three RNA splicing-related genetic variants contribute to lung cancer susceptibility in European populations. However, additional validation is needed, and specific splicing mechanisms of the target genes underlying the observed associations also warrants further exploration.
Effectiveness of the SCERTS Model–Based Interventions for Autistic Children: A Systematic Review
Authors: Yi Juhee , Kim Whasoo , Lee Jiwoo 
Published: June 2022

Purpose:
This systematic review aimed to examine the effectiveness of the Social Communication, Emotional Regulation, and Transactional Support (SCERTS) Model–based interventions in supporting developmental skills of children who were diagnosed with or at increased likelihood of autism.

Method:
We searched six electronic databases, in addition to Google Scholar and the reference lists, using terms related to SCERTS, the Early Social Interaction project, and autism spectrum disorder. Of the 70 articles, six published between 2014 and 2021 (a total of 455 children) were eligible for inclusion and were analyzed in terms of study design, type of publication, participant characteristics, intervention procedures, and major findings.

Results:
Most reviewed studies that were relatively less vulnerable to the given risk of bias suggested that SCERTS may be an effective approach for promoting children's social communication skills, and implementers were able to achieve an adequate level of intervention fidelity through training. Further implications could not be drawn concerning children's language, reduction in restricted repetitive behaviors, emotional regulation, adaptive behavior, play, cognitive skills, academic competence, and motor skills due to contradicting findings within limited evidence.

Conclusions:
Although SCERTS is a promising intervention with emerging evidence, more methodologically rigorous studies are needed to progress the research base of SCERTS and draw firm conclusions about its effectiveness in improving a wide range of skills for children and implementers. Several areas for future research are discussed.

Supplemental Material:

https://doi.org/10.23641/asha.20151842
Constraints to neutron-star kicks in high-mass X-ray binaries withGaiaEDR3
Authors: Fortin Francis , García Federico , Chaty Sylvain , Chassande-Mottin Eric , Simaz Bunzel Adolfo 
Published: June 2022

Context.All neutron star progenitors in neutron-star high-mass X-ray binaries (NS HMXBs) undergo a supernova event that may lead to a significant natal kick impacting the motion of the whole binary system. The space observatoryGaiaperforms a deep optical survey with exquisite astrometric accuracy, for both position and proper motions, that can be used to study natal kicks in NS HMXBs.Aims.Our aim is to survey the observed Galactic NS HMXB population and to quantify the magnitude of the kick imparted onto their NSs, and to highlight any possible differences arising between the various HMXB types.Methods.We performed a census of Galactic NS HMXBs and cross-matched existing detections in X-rays, optical, and infrared with theGaiaEarly Data Release 3 database. We retrieved their parallaxes, proper motions, and radial velocities (when available), and performed a selection based on the quality of the parallax measurement. We then computed their peculiar velocities with respect to the rotating reference frame of the Milky Way, and including their respective masses and periods, we estimated their kick velocities through Markov chain Monte Carlo simulations of the orbit undergoing a supernova event.Results.We infer the posterior kick distributions of 35 NS HMXBs. After an inconclusive attempt at characterising the kick distributions with Maxwellian statistics, we find that the observed NS kicks are best reproduced by a gamma distribution of mean 116−15+18km s−1. We note that supergiant systems tend to have higher kick velocities than Be HMXBs. The peculiar velocity versus non-degenerate companion mass plane hints at a similar trend, supergiant systems having a higher peculiar velocity independently of their companion mass.