bluuebunny/crossref_metadata_2025_split huggingface dataset:
A case of psoriasiform drug eruption caused by temozolomide
Authors: Oguro Tokuko , Nakajima Kimiko , Aoki Natsuko , Yamamoto Mayuko , Sano Shigetoshi 
Published: July 2022

AbstractPsoriasiform drug eruption is defined as condition similar to psoriasis triggered by drug administration, including de novo development of psoriasis or exacerbation of pre‐existing psoriasis. Herein, we describe a 52‐year‐old Japanese woman, who developed disseminated psoriasiform lesions following administration of temozolomide, a remedy for glioblastoma, although cutaneous adverse events by this drug was very rare. In addition, we assume that altered inflammatory signals associated with psoriasis, such as activation of signal transducer and activator of transcription 3 (STAT3), might be involved in the underlying pathomechanism of drug eruption caused by temozolomide.
Targeted parallel DNA sequencing detects circulating tumor‐associated variants of the mitochondrial and nuclear genomes in patients with neuroblastoma
Authors: Riehl Lara , Mulaw Medhanie , Kneer Katharina , Beer Meinhard , Beer Ambros , Barth Thomas F. , Benes Vladimir , Schulte Johannes , Fischer Matthias , Debatin Klaus‐Michael , Beltinger Christian 
Published: July 2022

AbstractBackgroundThe utility for liquid biopsy of tumor‐associated circulating single‐nucleotide variants, as opposed to mutations, of the mitochondrial (mt) and nuclear genomes in neuroblastoma (NB) is unknown.ProcedureVariants of the mt and nuclear genomes from tumor, blood cells, and consecutive plasma samples of five patients with metastatic NB that relapsed or progressed were analyzed. Targeted parallel sequencing results of the mt genome, and of the coding region of 139 nuclear genes and 22 miRNAs implicated in NB, were correlated with clinical imaging and laboratory data.ResultsAll tumors harbored multiple somatic mt and nuclear single nucleotide variants with low allelic frequency, most of them not detected in the circulation. In one patient a tumor‐associated mt somatic variant was detected in the plasma before and during progressive disease. In a second patient a circulating nuclear tumor‐associated DNA variant heralded clinical relapse. In all patients somatic mt and nuclear variants not evident in the tumor biopsy at time of diagnosis were found circulating at varying timepoints. This suggests either tumor heterogeneity, evolution of tumor variants or a confounding contribution of normal tissues to somatic variants in patient plasma. The number and allelic frequency of the circulating variants did not reflect the clinical course of the tumors. Mutational signatures of mt and nuclear somatic variants differed. They varied between patients and were detected in the circulation without mirroring the patients' course.ConclusionsIn this limited cohort of NB patients clinically informative tumor‐associated mt and nuclear circulating variants were detected by targeted parallel sequencing in a minority of patients.
A Randomized Thorough QT Study of Apomorphine Sublingual Film in Patients With Parkinson's Disease
Authors: Stocchi Fabrizio , Peckham Elizabeth L. , De Pandis Maria Francesca , Sciarappa Ken , Kleiman Robert , Agbo Felix , Olanow C. Warren , Blum David , Navia Bradford 
Published: July 2022

AbstractA randomized thorough QT study was conducted to assess the effects of apomorphine sublingual film (SL‐APO) on corrected QT interval (QTc) and other cardiac conduction parameters in patients with Parkinson's disease (PD) and “OFF” episodes. Patients were titrated to an SL‐APO dose that resulted in FULL “ON,” followed by up to two additional doses (maximum 60 mg), then randomized at the highest tolerated dose to a treatment sequence of SL‐APO, placebo, and moxifloxacin (400 mg, positive control) in a three‐way crossover design. Changes from baseline in time‐matched, placebo‐adjusted Fridericia‐corrected QTc interval (ΔΔQTcF) and Bazett‐corrected QTc interval (ΔΔQTcB) were analyzed from postdose electrocardiograms. Forty patients were randomized and received single doses of study treatments. Upper limits of 90% confidence intervals (CIs) for ΔΔQTcF of SL‐APO were below the 10‐millisecond regulatory threshold at all prespecified timepoints, demonstrating no clinically significant effect on QTcF. Lower limits of 90% CIs for ΔΔQTcF of moxifloxacin exceeded the 5‐millisecond regulatory threshold at all timepoints up to 3 hours, confirming assay sensitivity. SL‐APO had no clinically meaningful effects on QTcB, PR/QRS intervals, heart rate, or electrocardiogram‐derived morphology (EudraCT identifier: 2016‐001762‐29; ClinicalTrials.gov identifier: NCT03187301).
Intrusion detection system based firefly algorithm‐random forest for cloud computing
Authors: Moharamkhani Elaheh , Yahyaei Feriz Hendi Mohammad , Bandar Eisa , Izadkhasti Amir , Sirwan Raza Rzgar 
Published: July 2022

SummaryCloud computing is an active environment for accessing shared resources. Security in this environment, is one of the most important issues and concerns. An intrusion detection system is used to provide security and privacy. The intrusion detection system distinguishes between attacks and normal activities and prevents attacks on the cloud environment and notifies managers and cloud providers by creating alerts. Intrusion detection systems are usually implemented with different solutions. In this article, we present an intrusion detection system based on firefly algorithm and random forest algorithm that has the ability to detect intrusion with high accuracy in cloud computing, the results of model testing and evaluation, efficient and appropriate indicates the existence of the proposed method.
Genetic improvement of soybeans in Brazil: South and Midwest regions
Authors: Milioli Anderson Simionato , Meira Daniela , Panho Maiara Cecília , Madella Laura Alexandra , Woyann Leomar Guilherme , Todeschini Matheus Henrique , Zdziarski Andrei Daniel , Ramos Campagnolli Otávio , Menegazzi Caroline Patrícia , Colonelli Lucas Leite , Fernandes Rogê Afonso Tolentino , Melo Carlos Lásaro Pereira de , Fernandes de Oliveira Marcelo , Bertagnolli Paulo Fernando , Arias Carlos Alberto Arrabal , Giasson Nizio Fernando , Matsumoto Marcos Norio , Quiroga Marcos , Rossi Silva Raphael , Bertan Ivandro , Capelin Marcio Andrei , Matei Gilvani , Benin Giovani 
Published: July 2022

AbstractSoybean [Glycine max (L.) Merril] is one of the main crops produced worldwide, and on‐farm yields have increased considerably in the last decades in Brazil. We evaluated the genetic gain for agronomic, phenological, and end‐use quality traits in 29 cultivars in the South Region, and in 38 cultivars in the Midwest Region in Brazil, released from 1966 to 2011. Field trials were conducted in Macroregions 1, 2, and 4, in 2016–2017, 2017–2018, and 2018–2019 crop seasons. The best linear unbiased predictors (BLUP) of the cultivars were obtained for each trait using a linear model. The BLUPs were regressed with the year of release using linear and quadratic regression models. The rates of genetic gain for seed yield ranged from 11.98 to 15.31 kg ha–1 yr–1 (0.33 to 0.42% yr–1) in the South Region, and from 13.58 to 21.84 kg ha–1 yr–1 (0.47 to 0.77% yr–1) in the Midwest Region. New cultivars presented taller plants and more seed oil content, oil and protein yield, and lower seed weight, days to flowering, days to maturity, and seed protein content than old cultivars in the South Region, although with differences between the Macroregions. In the Midwest Region, new cultivars showed higher seed oil content, oil and protein yield, and lower bottom pod height and seed protein content than old cultivars. Our results showed that breeding programs have been efficient to improve soybean yield and other traits across the years, without yield plateaus in sight.
Hydrogen Borrowing: towards Aliphatic Tertiary Amines from Lignin Model Compounds Using a Supported Copper Catalyst
Authors: Ruijten Dieter , Narmon Thomas , De Weer Hanne , van der Zweep Robbe , Poleunis Claude , Debecker Damien P. , Maes Bert U. W. , Sels Bert F. 
Published: July 2022

AbstractUpcoming biorefineries, such as lignin‐first provide renewable aromatics containing unique aliphatic alcohols. In this context, a Cu‐ZrO2 catalyzed hydrogen borrowing approach was established to yield tertiary amine from the lignin model monomer 3‐(3,4‐dimethoxyphenyl)‐1‐propanol and the actual lignin‐derived monomers, (3‐(4‐hydroxyphenyl)‐1‐propanol and dihydroconiferyl alcohol), with dimethylamine. Various industrial metal catalysts were evaluated, resulting in nearly quantitative mass balances for most catalysts. Identified intermediates, side and reaction products were placed into a corresponding reaction network, supported by kinetic evolution experiments. Cu‐ZrO2 was selected as most suitable catalyst combining high alcohol conversion with respectable aliphatic tertiary amine selectivity. Low pressure H2 was key for high catalyst activity and tertiary amine selectivity, mainly by hindering undesired reactant dimethylamine disproportionation and alcohol amidation. Besides dimethylamine model, diverse secondary amine reactants were tested with moderate to high tertiary amine yields. As most active catalytic site, highly dispersed Cu species in strong contact with ZrO2 is suggested. ToF‐SIMS, N2O chemisorption, TGA and XPS of spent Cu‐ZrO2 revealed that imperfect amine product desorption and declining surface Cu lowered the catalytic activity upon catalyst reuse, while thermal reduction readily restored the initial activity and selectivity demonstrating catalyst reuse.
Overview and update on molecular testing in non‐small cell lung carcinoma utilizing endobronchial ultrasound‐guided transbronchial needle aspiration (EBUS‐TBNA) samples
Authors: Fernández Aceñero María Jesús , Díaz del Arco Cristina , Dinarés Carme , Labiano Tania , Tejerina Eva , Bernabé Mª José , Forcen Elena , Saiz‐Pardo Melchor , Pérez Pablo , Lozano Maria D. 
Published: July 2022

AbstractLung carcinoma remains one of the most frequent and aggressive human neoplasms. Fortunately, in the last decades, the increasing knowledge of the molecular mechanisms leading to cancer development has allowed the use of targeted therapies with improvement of prognosis in many patients. Clinical management has also changed after the introduction of endobronchialultrasonographic bronchoscopy that allows a conservative staging of lung tumors, avoiding the need of mediastinoscopy for lymph node staging. Lung pathologists and cytopathologists are facing the challenge of giving the more comprehensive prognostic and predictive information with ever smaller tissue or cytological samples. The aim of this review is to summarize the molecular testing for non‐small cell lung carcinoma and how pathologists can contribute to the patient's outcome with a conscious management of biological samples.
Cannabigerol (CBG) attenuates mechanical hypersensitivity elicited by chemotherapy‐induced peripheral neuropathy
Authors: Sepulveda Diana E. , Morris Daniel P. , Raup‐Konsavage Wesley M. , Sun Dongxiao , Vrana Kent E. , Graziane Nicholas M. 
Published: July 2022

AbstractBackgroundCannabigerol (CBG) is a non‐psychoactive phytocannabinoid produced by the plant Cannabis sativa with affinity to various receptors involved in nociception. As a result, CBG is marketed as an over‐the‐counter treatment for many forms of pain. However, there is very little research‐based evidence for the efficacy of CBG as an anti‐nociceptive agent.MethodsTo begin to fill this knowledge gap, we assessed the anti‐nociceptive effects of CBG in C57BL/6 mice using three different models of pain; cisplatin‐induced peripheral neuropathy, the formalin test, and the tail‐flick assay.ResultsUsing the von Frey test, we found that CBG‐attenuated mechanical hypersensitivity evoked by cisplatin‐induced peripheral neuropathy in both male and female mice. Additionally, we observed that this CBG‐induced reduction in mechanical hypersensitivity was attenuated by the α2‐adrenergic receptor antagonist atipamezole (3 mg/kg, i.p.) and the CB1R antagonist, AM4113 (3 mg/kg, i.p.), and blocked by the CB2R antagonist/inverse agonist, SR144528 (10 mg/kg, i.p.). We found that the TRPV1 antagonist, SB705498 (20 mg/kg, i.p.) was unable to prevent CBG actions. Furthermore, we show that CBG:CBD oil (10 mg/kg, i.p.) was more effective than pure CBG (10 mg/kg) at reducing mechanical hypersensitivity in neuropathic mice. Lastly, we show that pure CBG and CBG:CBD oil were ineffective at reducing nociception in other models of pain, including the formalin and tail flick assays.ConclusionsOur findings support the role of CBG in alleviating mechanical hypersensitivity evoked by cisplatin‐induced peripheral neuropathy, but highlight that these effects may be limited to specific types of pain.SignificanceThere are few effective treatments for neuropathic pain and neuropathic pain is projected to increase with the aging population. We demonstrate that CBG (cannabigerol) and CBG:CBD oil attenuate neuropathy‐induced mechanical hypersensitivity mice. Second, we identify receptor targets that mediate CBG‐induced reduction in mechanical hypersensitivity in neuropathic mice. Third, we demonstrate that an acute injection of CBG is anti‐nociceptive specifically for neuropathic pain rather than other forms of pain, including persistent pain and thermal pain.
Nonparametric estimation of variable productivity Hawkes processes
Authors: Paik Schoenberg Frederic 
Published: July 2022

AbstractHawkes models are frequently used to describe point processes that are clustered spatial‐temporally, and have been used in numerous applications including the study of earthquakes, invasive species, and contagious diseases. An extension of the Hawkes model is considered where the productivity is variable. In particular, the case is explored where each point may have its own productivity and a simple analytic formula is derived for the maximum likelihood estimators of these productivities. This estimator is compared with an empirical estimator and ways are explored of stabilizing both estimators by lower truncating, smoothing, and rescaling the estimates. Properties of the estimators are explored in simulations, and the methods are applied to seismological and epidemic datasets to show and quantify substantial variation in productivity.
A new double Z‐scheme TiO2/ZnO‐g‐C3N4 nanocomposite with enhanced photodegradation efficiency for Rhodamine B under sunlight
Authors: Hongxia Jing , Yanlin Gao , Longxiang Li , Xu Wang , Wangjun Pei 
Published: July 2022

AbstractThe double Z‐scheme TiO2/ZnO‐g‐C3N4 nanophotocatalyst was prepared by sol–gel method and solvothermal method. X‐ray diffractometer, FT‐IR, transmission electron microscopy, energy dispersive X‐ray spectrum, ultraviolet–visible (UV–vis), PL, EIS, and so on were used to characterize the structure, morphology, chemical composition, and optical properties of the prepared photocatalyst. And Rhodamine B (RhB) was used as a simulated organic pollutant to study the photocatalytic performance of the photocatalyst. The experimental results show that the double Z‐scheme TiO2/ZnO‐g‐C3N4 nanophotocatalyst exhibits high photocatalytic performance under both ultraviolet light and sunlight, and the RhB in the solution can be completely removed in 120 min. This article also proposes a possible Z‐scheme photocatalytic mechanism to explain the increased photocatalytic activity.
Magnetic urchin‐like NiCo2O4 material derived from wastes as a peroxymonosulfate activator for the degradation of bisphenol A
Authors: Wang Xiaowei , Wu Fengmin , Cai Junqing , Luo Jie , Zhang Junkai , Niu Yongping 
Published: July 2022

AbstractIn this study, the magnetic urchin‐like NiCo2O4 materials (NiCo2O4‐w) were successfully prepared from the waste during the preparation of NiCo2O4/carbon cloth composite, and further evaluated as a peroxymonosulfate activator for removing bisphenol A (BPA). The effect of various factors such as initial solution pH, peroxymonosulfate (PMS) concentration, catalyst concentration, and coexisting ions on the BPA removal were evaluated. The optimal factors were 0.20 g L−1 catalyst, 0.10 g L−1 PMS, 7.14 pH (unadjusted). Moreover, the NiCo2O4‐w exhibited good catalytic effects over wide ranges of pH (3.73 to 12). SO42− and H2PO4− remarkably inhibited the BPA removal, NO3− obviously inhibited the BPA removal, while Cl− and HCO3− had a little effect on the BPA removal. Singlet oxygen (1O2), superoxide radical (O2•−), hydroxyl radical (•OH) and sulfate radical (SO4•−) participated in the BPA degradation, of which O2•− and 1O2 played the leading role, especially O2•−. Oxygen vacancies, redox cycling pairs of Co(III)/Co(II) and Ni(III)/Ni(II) were responsible for PMS activation. Moreover, the degradation routes of BPA were rationally put forward. This present work not only presents that NiCo2O4‐w has a low‐cost, magnetically recoverable catalyst for high efficient degradation of wastewater containing BPA, but also opens up a new avenues to reduce environmental problems associated with waste treatment during the preparation of heterogeneous catalyst.
Effect of port water injection on suppressing knock in gasoline direct injection engines
Authors: Dai Xuejiao , Zheng Zhaolei , Song Yukun 
Published: July 2022

AbstractThe effect of different port water injection (PWI) ratios on the knock in gasoline direct injection engines is explored. First, a simulation study is carried out under knock conditions to explore the time and location of the knock and the chemical mechanism that causes it. Second, water injection amount to 10%, 20%, 30%, and 40% are set to explore the effects of different water injection ratios on knocking. The influence of the different water injection ratios on the chemical mechanism of knocking is evaluated and that of the chemical mechanism on the in‐cylinder temperature and the impact of heat release rate (HRR) is explored. The results show that PWI can effectively reduce the occurrence of spontaneous combustion in the cylinder by reducing the flame propagation speed. On one hand, the changes in the low‐temperature reaction substances CH2O and HRR tend to be consistent and the peaks of CH2O and HRR move back with the increase in water injection. So, different ratios of PWI can affect the flame propagation speed by affecting the generation and consumption of CH2O, OH radicals, and HCO radicals. Also, PWI can significantly reduce the generation of in‐cylinder OH radicals, ultimately suppressing the generation of the high‐temperature stage. In addition, PWI can effectively reduce the mean temperature and mean pressure. Compared to other water injection ratios, a 30% water injection ratio is the most effective at inhibiting knocking. At this time, the knocking intensity is the lowest, and the cycle power reaches its maximum of 1120 J.
Pilot Study of Pollution Characteristics and Ecological Risk of Disinfection Byproducts in Natural Waters in Hong Kong
Authors: Liu Jing , Hu Li-Xin , Deng Wen-Jing , Ying Guang-Guo , Hong Huachang , Tsang Eric P. K. , Barceló Damià 
Published: July 2022

Abstract
Increased disinfection efforts in various parts of China, including Hong Kong, to prevent the spread of the novel coronavirus may lead to elevated concentrations of disinfectants in domestic sewage and surface runoff in Hong Kong, generating large quantities of toxic disinfection byproducts. Our study investigated the presence and distribution of four trihalomethanes (THMs), six haloacetic acids (HAAs), and eight nitrosamines (NAMs) in rivers and seawater in Hong Kong. The concentrations of THMs (mean concentration: 1.6 µg/L [seawater], 3.0 µg/L [river water]), HAAs (mean concentration: 1.4 µg/L [seawater], 1.9 µg/L [river water]), and NAMs (mean concentration: 4.4 ng/L [seawater], 5.6 ng/L [river water]) did not significantly differ between river water and seawater. The total disinfection byproduct content in river water in Hong Kong was similar to that in Wuhan and Beijing (People's Republic of China), and the total THM concentration in seawater was significantly higher than that before the COVID-19 pandemic. Among the regulated disinfection byproducts, none of the surface water samples exceeded the maximum index values for THM4 (80 μg/L), HAA5 (60 μg/L), and nitrosodimethylamine (100 ng/L) in drinking water. Among the disinfection byproducts detected, bromoform in rivers and seawater poses the highest risk to aquatic organisms, which warrants attention and mitigation efforts. Environ Toxicol Chem 2022;41:2613–2621. © 2022 SETAC
A hybrid immersed‐boundary/body‐fitted‐grid method and its application to simulating heart valve flows
Authors: Wang Jingyang , Zhou Chunhua , Ai Junqiang 
Published: July 2022

AbstractIn this article, a hybrid immersed‐boundary (IB)/body‐fitted‐grid (BFG) method is presented for simulating flows with immersed moving boundaries. In this method, the stationary solid boundaries are treated by the BFG method while the moving boundaries are treated by an immersed boundary method named the local domain‐free discretization method. The hybrid IB/BFG method has both the advantage of an IB method in handling the moving boundaries and that of a BFG method in handling the stationary boundaries and the boundary layers over them. The present method is beneficial to heart valve flows where the leaflets are implanted in a blood vessel. For the simulation of pulsatile heart valve flows, a technique of driving force is proposed to maintain the conservation of the mass flux and improve the convergence of the pseudo‐time iteration in dual‐time‐stepping. The wall‐modeled large eddy simulation is employed for simulating turbulence. Numerical experiment is first performed for the pulsatile flow through a curved, pipe bend. To demonstrate the ability of the proposed method to simulate flows with complex, immersed boundaries, pulsatile physiological flows through a bileaflet mechanical heart valve mounted in a model straight aorta are calculated. The predicted results show good agreements with the published experimental data and numerical results.
Determining the heat of desorption for cassava products based on data measured by an automated gravimetric moisture sorption system
Authors: Sarnavi Hamed J , Precoppe Marcelo , García‐Triñanes Pablo , Chapuis Arnaud , Tran Thierry , Bradley Michael SA , Müller Joachim 
Published: July 2022

AbstractBACKGROUNDThe isosteric heat of desorption is vital in evaluating the energy performance of food dryers. The isosteric heat of desorption was investigated for different cassava (Manihot esculenta Crantz) products prepared as flour or starch, with and without fermentation. An automated moisture sorption gravimetric analyser was used to measure the desorption isotherms over 10–90% relative humidity of the drying air at temperatures ranging from 25 to 65 °C.RESULTSAnalysis of variance showed an imperceptible contribution of the preparation method in the measured desorption data. This finding also agreed with microscopical images, which revealed the lack of compelling structural differences among different products. A set of empirical sorption equations suggested by the ASAE standard was examined over the measured desorption isotherms. The standard error of estimation was found to be in the acceptable range of 2.36–3.71%. Furthermore, the fulfilment of the enthalpy‐entropy compensation theory was considered as an additional criterion in the thermodynamic results of different sorption equations, besides their fitting adequacy. The modified Chung–Pfost equation has proved to be the most suitable equation for cassava products, as it is capable of reflecting the temperature dependency of the isosteric heat of desorption. The net isosteric heat of desorption obtained was in the range of 540–1110 kJ kg−1 for 0.10 kg kg−1 dry‐basis moisture content and 52–108 kJ kg−1 for 0.25 kg kg−1 dry‐basis moisture content.CONCLUSIONThese findings are technologically relevant for optimising common drying technologies such as flash and flatbed dryers. © 2022 The Authors. Journal of The Science of Food and Agriculture published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.