bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prognostic Identifier of Cerebrovascular Complications in Tuberculous Meningitis: Meta-Analysis
Authors: Tomidy Julianto , Satriadinatha Gede Bagus Yoga , Liwang Filbert Kurnia , Maharani Kartika , Imran Darma , Estiasari Riwanti 
Published: July 2022

Abstract

Purpose: This study aimed to find predictors of stroke in patients with tuberculous meningitis.Methods: This systematic review and meta-analysis were done using literature searches through online databases up to April 30th, 2022. Three independent authors performed literature screening, data extraction, and critical appraisal of the studies. Eight studies involving 1535 samples were included.Results: We analyzed data regarding demographic, comorbidity, clinical presentation, radiologic, and laboratory parameters. Overall, clinical presentation that showed outcome difference was found in patients with findings of vomiting (OR = 2.71, 95% CI: 1.30-5.63), cranial nerve deficit (OR = 4.10, 95% CI: 1.83-9.21), focal deficit (OR = 5.56, 95% CI: 2.24-13.79), and altered consciousness (OR = 1.90, 95% CI: 1.24-2.92). Some comorbidities showed significant differences such as diabetes mellitus (OR = 2.58, 95% CI: 1.51-4.41), hypertension (OR = 5.73, 95% CI: 3.36-9.77), ischemic heart disease (OR = 2.18, 95% CI: 1.02-4.63), and smoking (OR = 2.65, 95% CI: 1.22-5.77). Two radiological changes shown to have significantly higher proportions are hydrocephalus (OR = 2.50, 95% CI: 1.74-3.58) and meningeal enhancements (OR = 3.99, 95% CI: 1.73-9.20).Conclusion: Our analysis indicated that clinical presentations of vomiting, cranial nerve deficit, focal deficit, altered consciousness; comorbidity of diabetes mellitus, hypertension, smoking history, ischemic heart disease; and radiological findings of meningeal enhancement and hydrocephalus showed significant association with stroke incidence in tuberculous meningitis.
Multiscale Optical Imaging with Real Time Projection of Cancer Risk and Biopsy Guidance Maps for Early Oral Cancer Diagnosis and Treatment
Authors: Coole Jackson , Brenes David , Mitbander Ruchika , Vohra Imran , Hou Huayu , Kortum Alex , Tang Yubo , Maker Yajur , Schwarz Richard , Carns Jennifer , Badaoui Hawraa , Williams Michelle , Vigneswaran Nadarajah , Gillenwater Ann , Richards-Kortum Rebecca 
Published: July 2022

Abstract
When detected early, oral precancer and cancer can be treated with surgical resection with successful long-term clinical outcomes. Despite easy accessibility of the oral cavity, conventional oral examination has limited sensitivity and specificity to detect early neoplastic changes. Several optical imaging tools have shown promise to improve early detection of oral neoplasia, but they do not provide visible guidance to help clinicians determine when and where to biopsy suspicious oral lesions. Here, we demonstrate a low-cost, portable Active Biopsy Guidance System (ABGS) that uses multi-scale optical imaging with deep learning algorithms to create and directly project cancer risk maps onto clinically visible oral potentially malignant disorders (OPMDs) to guide biopsy locations in real time. Representative patient examples highlight these clinically actionable visualizations that are provided in real-time during an imaging procedure through automated processing of imaging data. Results show multiscale optical imaging with cancer-risk map projection offers a versatile, quantitative and precise tool to guide biopsy site selection and improve the early detection of oral epithelial cancers and their precursors.
Rubber-dam usage by dentists and the pandemic: a questionnaire study
Authors: TURHAN Zübeyde Gökçe , KAPLAN Gizem , TINAZ Ali Cemal 
Published: July 2022

Abstract
ObjectivesThis study aimed to compare the frequency of rubber-dam usage by dentists in different specialties before and after the coronavirus disease (COVID-19) pandemic.Materials and MethodsA questionnaire was delivered electronically to dentists in different specialties during May 2021. This questionnaire included questions about the demographics and professional backgrounds of the dentists, and their opinions about and the frequencies of use of the rubber-dam. Additionally, whether their rubber-dam usage approaches were affected by the COVID-19 pandemic was also questioned.ResultsRegardless of the specialty, it was found that the frequency of using rubber-dams decreased inversely as the years of professional experience increased (P < 0.05). When specialties were considered, endodontists used rubber-dams during endodontic and restorative procedures significantly more often than the others (P < 0.05). When the workplaces were compared, it was seen that rubber-dams were used significantly more often in university clinics (P < 0.05). Among the participants, 36.4% said that the frequency of using rubber-dams increased after the pandemic. In addition, it was seen that the frequency of rubber dam usage increased statistically significantly after pandemic among dentists from all specialties who agreed with the statement “Using a rubber dam is always beneficial in restorative and endodontic procedures” (P < 0.05).Conclusions and Clinical RelevanceDespite the quality guideline recommendations, the use of rubber dams is still not at the desired level; however, there has been an increase in the number of dentists using them after the pandemic began.
Identification of microfilariae in canine blood samples from the city of Aracaju (Sergipe, northeastern Brazil)
Authors: Lee Daniel 
Published: July 2022

Abstract
This study reported the occurrence of microfilariae from blood samples of dogs from the city of Aracaju, Sergipe, and correlate the prevalence of those infections with the age and sex of the analyzed animals. Each blood samples collected from the cephalic, radial, or jugular veins was processed under modified Knott’s technique and analyzed in triplicates. A total of 378 dogs were analyzed during the study and a total of 15 (4%) animals were positive to circulating microfilariae, being 14 (3.7%) positive for Dirofilaria immitis and 1 (0.3%) for Acanthocheilonema reconditum. The statistical analysis of the results demonstrated a significant correlation between the prevalence of D. immitis and A. reconditum and age of animals, with the rate of infections increasing with the age. A total of 7 females and 8 males were positive to circulating microfilariae, with no significant statistical correlation between those variables. Those results evidence the presence of mosquito-borne blood filarial diseases in dogs from the city of Aracaju and the need to reinforce the diagnosis, treatment and control of these potentially zoonotic diseases.
The circadian clock gene ARNTL overexpression suppresses oral cancer progression by inducing apoptosis via activating autophagy
Authors: Li Hanxue , Li Meng , Chen Kuichi , Li Yueheng , Yang Zhengyan , Zhou Zhi 
Published: July 2022

Abstract
Objective The study aimed to explore tumor suppressor mechanism of ARNTL from the perspective of autophagy in oral cancer Methods Human oral squamous carcinoma HN6 cells stably overexpressing ARNTL were established, cell viability and apoptosis were detected by CCK-8 and TUNEL assays, and intracellular autophagosomes were observed under electron microscopy. Western Blot detected expressions of Beclin1, LC3 II/I, ATG-12, P62, BAX and BCL-2. Bafilomycin A1 was used to detect autophagic flux, and Western Blot was used to detect changes of LC3II and P62 proteins. Autophinib was added to cells with ARNTL overexpression for recovery experiments, and cell proliferation and apoptosis were detected by flow cytometry. In vivo tumorigenesis experiment was used to evaluate the in vivo anti-tumor efficacy of ARNTL, and Western blot simultaneously detected ARNTL, LC3 II/I, Beclin1, P62 and ATG-12 expressions. Results ARNTL overexpression promoted apoptosis and autophagy and inhibited cell viability. In ARNTL-overexpressing cells, expressions of Beclin1, LC3 II/I, and BAX were significantly up-regulated, while P62 and BCL-2 expressions were decreased, and ATG-12 expression wasn't significantly changed. When the autophagy inhibitor Autophinib was used, expressions of elevated BAX and decreased BCL-2 were reversed effectively, as were decreased cell proliferation index and increased apoptosis index. An in vivo tumorigenesis assay also showed ARNTL overexpression inhibited tumor growth, and autophagy-related protein expressions were consistent with the in vitro data. Conclusions The research demonstrated for the first time that ARNTL induced apoptosis and inhibit cell proliferation dependent on autophagy in oral cancer, which provides theoretical basis for potential therapeutic targets.
A progressive phased attention model fusing histopathology and genomic features for lung cancer staging
Authors: Cai Meiling , Zhao Lin , Zhang Yanan , Wu Wei , Jia Liye , Zhao Juanjuan , Yang Qianqian , Qiang Yan 
Published: July 2022

Abstract
Morphological information from histopathology slides and molecular profiles from genomic data are important for predicting the staging of lung cancer. However, most deep learning-based prediction results are based on histopathology or genomics alone, which do not fully utilize the complementary information of both and ignore staining differences in histopathology images due to different staining conditions. In this study, we propose a Multimodal Multi-scale Attention Model (MMAM) to predict patients’ lung cancer staging outcomes by end-to-end multimodal fusion of patients' multi-scale histopathology image features with genetic features by augmented attention. The proposed MMAM consists of two phases. In the first phase, a Staining Difference Elimination Network (SDEN) is proposed for stable detection of histopathology image features to eliminate differences arising from different hospital/specimen staining conditions. In the second phase, we design a Multimodal Multi-scale Fusion Network (MMFN) to efficiently fuse different modality features. We have validated our approach on the lung cancer dataset from The Cancer Genome Atlas (TCGA). The results show that the proposed MMAM improves the staging effectiveness of the fusion network of histopathological and genomic features, reduces the effect of appearance variability due to staining differences on blurred pictures, achieves an AUC of 88.51%, and outperforms other popular methods in predicting lung cancer staging.
A batch parameter elimination algorithm for improving the efficiency of multi- GNSS integrated orbit determination
Authors: Yan Xingyuan , Liu Chenchen , Yang Meng , Feng Wei , Zhong Min 
Published: July 2022

Abstract
The increased number of satellites and stations expands the dimensions of the normal equation system (NEQ), which lead to the serious time consumption of the integrated precise orbit determination (POD), especially in the current Global Navigation satellite system (GNSS) with more than 120 satellites. To improve the computational efficiency of multi-GNSS integrated POD, this paper proposes a novel parameters elimination algorithm based on intel oneAPI High-Performance Computing (HPC), where the parameters are only divided into active and inactive parts. Among them, the inactive parameters are concentrated at the beginning of the NEQ, and eliminated in a batch based on matrix block computation. Compared with the classical "one-by-one" elimination method, it can significantly improve the efficiency of Least Square Adjustment (LSQ), with ratios of 2.53, 4.21, and 5.38 for 79, 126, and 171 stations’ POD, respectively. Meanwhile, its advantage is that as the number of stations increases, the time consumption is still closer to a linear trend than the classical and parallel elimination methods. Moreover, this algorithm adopted serial programming, which also retained the advantage of the serial algorithm to the small CPU occupancy. Therefore, multi-day POD parallelism based on the proposed algorithm can further improve the efficiency of the whole post-processing task, for instance, satellite antenna phase center offset modeling.
What Goes in Must Come Out? The Metabolic Profile of Plants and Caterpillars, Frass, and Adults of Asota (Erebidae: Aganainae) Feeding on Ficus (Moraceae) in New Guinea
Authors: Segar Simon , FONTANILLA ALYSSA M. , AUBONA GIBSON , SISOL MENTAP , KUUKKANEN ILARI , SALMINEN JUHA-PEKKA , MILLER SCOTT E. , HOLLOWAY JEREMY D. , NOVOTNY VOJTECH , VOLF MARTIN 
Published: July 2022

Abstract
Insect herbivores have evolved a broad spectrum of adaptations in response to the diversity of chemical defences employed by plants. Here we focus on two species of New Guinean Asota and determine how these specialist moths deal with the leaf alkaloids of their Ficus fig hosts. As each focal Asota species is restricted to one of three chemically distinct species of Ficus, we also test whether these specialised interactions lead to similar alkaloid profiles in both Asota species. We reared Asota caterpillars on their respective Ficus hosts in natural conditions and analysed the alkaloid profiles of leaf, frass, caterpillar, and adult moth samples using UHPLC–MS/MS analyses. We identified 43 alkaloids in our samples. Leaf alkaloids showed various fates. Some were excreted in frass or found in caterpillars and adult moths. We also found two apparently novel indole alkaloids—likely synthesised de novo by the moths or their microbiota—in both caterpillar and adult tissue but not in leaves or frass. Overall, alkaloids unique or largely restricted to insect tissue were shared across moth species despite feeding on different hosts. This indicates that a limited number of plant compounds have a direct ecological function that is conserved among the studied species. Our results provide evidence for the importance of phytochemistry and metabolic strategies in the formation of plant–insect interactions and food webs in general. Furthermore, we provide a new potential example of insects acquiring chemicals for their benefit in an ecologically relevant insect genus.
Impact of modified multiple thread ligations on operative outcomes of grade III hemorrhoids: A retrospective cohort study
Authors: Zhou Xile , Sheng Guixian , Zhao Long , Jiang Weiqing , Liu Chaoxu , Wu Guosheng 
Published: July 2022

Abstract
Objective
To explore the operative outcomes of patients underwent modified technique of multiple thread ligations (MTL) with the stapled hemorrhoidopexy (SH) technique for the management of grade III hemorrhoids.
Methods
This retrospective cohort study included patients who underwent MTL (MTL group) or SH (SH group) for grade III hemorrhoids in the first affiliated hospital of Zhejiang University between June 2019 and May 2021. The primary outcome was the recurrence of prolapse within six months. Secondary outcomes were operative time, postoperative pain scores, hospital stay, the incidence of complications, Wexner incontinence score on day 1 postoperative, and quality of life of patients with constipation (Patient Assessment of Constipation-Symptoms [PAC-SYM] questionnaire and Patient Assessment of Constipation-Quality of Life [PAC-QOL] questionnaire).
Results
A total of 115 patients in MTL group and 115 matched (age, sex, incontinence score, baseline PAC-SYM and baseline PAC-QOL) patients in SH group were finally included. MTL and SH resulted in comparable recurrence within six months of follow-up, with five and seven cases of recurrence respectively (P = 0.352). The two groups had comparable outcomes in terms of postoperative pain, hospital stay, Wexner incontinence scores, and constipation-related quality of life (all P > 0.05). Multivariate analysis suggested the MTL technique was not associated with a lower risk of postoperative bleeding than the SH technique (OR(95%CI): 8.332(0.923 ~ 75.200), P = 0.059).
Conclusion
The modified MTL technique might achieve comparable operative outcomes compare to the SH technique for the management of grade III hemorrhoids.
Usability of Open Educational Resources among Students of Al Kabir Polytechnic, Jamshedpur, India: A Case Study
Authors: Francis Ogunbodede Kolawole , Antique Mohammad 
Published: July 2022

Abstract
The purpose of this study is to determine the extent to which Al Kabir Polytechnic students in Jamshedpur, India, find Open Educational Resources (OER) useful. The investigation was directed by four research questions and a hypothesis. A descriptive survey was used by the researchers. A total of 1000 students from Al Kabir Polytechnic were included in the study. The sample size, which is 300 students, represents 30% of the overall population. The study's sample size was determined using the Taro Yamane sample size formula. For data gathering, a questionnaire was used. Educational technology professionals helped to validate the questionnaire. Cronbach Alpha was used to determine the instrument's reliability, and the result was 0.98. The mean and standard deviation were calculated using Statistical Product and Service Solutions (SPSS) version 23, and Pearson's product-moment correlation coefficient was used to test the hypothesis at 0.05 significant levels. The students had a high level of awareness and the use of OER. Students had a high level of usage of OER, according to the survey. It was also shown that a lack of digital literacy abilities was the most significant barrier to effective OER use. Finally, the hypothesis test reveals that there is a substantial link between student awareness and the use of OER. The positive link implied that students' awareness of OER had a favorable impact on their use in the study. The researchers proposed that the school administration and library management provide training on digital literacy skills for students to effectively use these resources based on the findings. Again, librarians and lecturers should continue to promote OER use among students to sustain its use.
Zinc Levels Assay in Children with Autism Spectrum Disorder by Quantum Magnetic Resonance Analyzer and Direct Colorimetry
Authors: Zayed Khalid Mahmoud El Sayed , Ibrahim Mostafa Azzaz 
Published: July 2022

Abstract
Background: Autism is a long-term disability and a developmental disorder in which many studies suggested an association with serum low levels of zinc. In addition, the zinc to copper (Zn/Cu) ratio can be a biomarker of ASD as it is abnormally low in individuals with autism.Aim: The present study aimed to determine the levels of Zn in the bodies of children with autism spectrum disorder (ASD). The assay is done using new technology, the quantum magnetic resonance analysis (QMRA) method, and comparing its results with a reference testing laboratory method to determine the validity, sensitivity, and specificity of the new measurement method.Method: The study was performed in a group of children (M=19; F=11; age range=3-15 years) with ASD (n=30) and a control group of typically developing children (n=30) matched in terms of sex and age. The main variables in this study were the body values of Zn measured with a QMRA-998 8th Generation device and in patients’ sera by the reference direct colorimetric method.Statistical Analysis: Results were compared across groups using descriptive statistics, Pearson and Spearman’s correlation coefficients, Chi-Square significance, analysis of variance (ANOVA), and linear regression. In addition, a sensitivity and specificity cross-tabulation test was performed to evaluate the QMRA method in measuring Zn levels.Results: Both methods showed lower means for Zn levels in the ASD group than in the control group with a significant correlation between the two methods when measuring Zn levels. With the QMRA method, the sensitivity was 84% and specificity was 87%.Conclusion: It is suggested to test blood levels of Zn in all autistic children and give them a Zn supplement if needed. Non-invasive health measurement devices such as QMRA can be used as a screening or adjunct tool for the measurement of Zn levels in humans.
Characteristics of DH type IIs, CMEs and flares of geoeffective and non-geoeffective storm events in Solar Cycle 24
Authors: Pant Charita , Pande Bimal , Pande Seema 
Published: July 2022

Abstract
In this paper, a statistical study on geoeffectiveness of CMEs integrated with DH-type II radio bursts, association of Dst with plasma and interplanetary field parameters (T,V,P,β,Bz,Bt,E) and their product function BzV for solar cycle 24 is presented. We have selected 119 DH-CME events from March 2008 to December 2015. Based on minimum Dst index ≤−50 nT of geo­magnetic storm, the events are assorted into two groups, specifically (i) Geoeffective events (ii) Non-geoeffective events. The geoeffective events are found to have high start frequency, low end frequency, broad bandwidth, long duration, slower drift rate than non-geoeffective events. CME speed and flare flux for geoeffective events are moderately correlated(r=0.50) which shows that flares may be related to geomagnetic storms through CMEs. Higher speed of CMEs associated with geoeffective events suggests that CME speed is an important pa­rameter for geoeffectiveness. A large fraction of CME associated with DH-type-II radio bursts are linked with geomagnetic storm which again indicates that CMEs accompanied by DH-type-II radio bursts are effectively responsible for producing geomagnetic storms. A good correlation of Dst with BzV(r>0.5) reflects that interplanetary field and plasma parameters also play an important role in the occurence of geomagnetic storms.
Valorization of pineapple peels: Production of vinegar enriched with red-Jambo (Syzygium malaccense) leaf extract
Authors: Bertan Fernanda Aparecida Brocco , Ronning Eduardo da Silva Pereira , Marchioro Marcelo Luis Kuhn , Oldoni Tatiane Luiza Cadorin , Dekker Robert F. H. , Cunha Mário Antônio Alves da 
Published: July 2022

Abstract
Pineapple peel vinegar was produced by the traditional system and enriched with the leaf extract of Syzygium malaccense (L.) Merr. & L.M. Perry. Appreciable phenolic contents and antioxidant potential were found in pulp and peel vinegar added of the extract. Catechin, epicatechin and caffeic, p-coumaric, ferulic, and gallic acids were the main phenolic compounds found in peel vinegar. The enrichment of the vinegar with the extract promoted an increase in the content of polyphenols (443.6-337.3 mg GAE/L) and antioxidant activity. Peel wines presented higher luminosity (L*) and higher saturation index (C*), and their color tended more towards yellow than pulp wines. Acetification reduced the saturation index (C*) and led to the intensification of the hue angle in the peels vinegar. All types of vinegar showed biocidal activity against different bacteria and yeast, and the addition of the extract potentiated the antimicrobial activity of peel vinegar, especially against S. aureus.