bluuebunny/crossref_metadata_2025_split huggingface dataset:
Long-term effect of non-surgical periodontal treatment on glycaemic control in patients with diabetes with periodontitis: a systematic review and meta-analysis of randomized controlled trials
Authors: Bakari William Ndjidda , Diallo Ahmad Moustapha , Danwang Celestin , Anagnostou Fani , Guirassy Mouhammadou Lamine , Benoist Henri Michel 
Published: August 2022

Abstract
Aim
This study aimed to determine whether non-surgical periodontal therapy (NSPT), with or without antimicrobial adjuvant therapy, in diabetic patients with periodontitis was effective in significantly reducing glycated haemoglobin (HbA1c) over six months compared to no active treatment.
Methods
MEDLINE, EMBASE and CENTRAL were searched to identify randomized controlled trials with a follow-up period of at least 6 months. The risk of bias was investigated by the Cochrane intention-to-treat risk of bias assessment tool (ROB 2) with 6-month HbA1C as the primary outcome. A random-effects meta-analysis was conducted to obtain the overall effect of non-surgical periodontal therapy on HbA1c levels. A subgroup analysis according to the type of adjuvant therapy was conducted.
Results
The literature search yielded 1848 studies, of which 10 were finally retained. An overall low risk of bias was found in four studies. The pooled mean difference of HbA1c between the intervention and control groups at 6 months and 9 months for non-surgical periodontal therapy was − 0.11% (95% CI: -0.31 to 0.09) and − 0.21 (95% CI: -0.72 to 0.29) respectively. Compared to the control group, periodontal parameters (plaque index, bleeding on probing, probing pockets depth, and clinical attachment levels) as well as levels of selected inflammation markers (C-reactive protein and tumor necrosis factor-α) were significantly (P-value < 0.05) improved in the intervention group.
Conclusion
NSPT with or without adjuvant contributed to a modest, although not statistically significant, improvement in glycaemic control at 6 and 9 months in diabetic patients with periodontitis.
Familial clustering of dysbiotic oral and fecal microbiomes in juvenile dermatomyositis
Authors: Koester Sean T. , Chow Albert , Pepper-Tunick Evan , Lee Peggy , Eckert Mary , Brenchley Laurie , Gardner Pamela , Li Naisi , Schiffenbauer Adam , Volochayev Rita , Bayat Nastaran , McLean Jeffrey S. , Rider Lisa G. , Shenoi Susan , Stevens Anne M. , Dey Neelendu 
Published: August 2022

Abstract
Background: Juvenile dermatomyositis (JDM) is a rare immune-mediated disease of childhood that is thought to result from genetic predisposition and environmental drivers, with documented links to microbial exposures. In this multi-center, prospective, observational cohort study, we evaluated whether JDM is associated with discrete oral and gut microbiome signatures.Methods: We generated 16S rRNA sequencing data from fecal, saliva, supragingival, and subgingival plaque samples from JDM probands (n=28, age range 3-18 years, mean age 10 years, 46% female). To control for genetic and environmental determinants of microbiome community structure to the greatest extent possible, we also profiled microbiomes of their unaffected family members (n=27 siblings, n=26 mothers, and n=17 fathers). We performed paired within-family comparisons as well as unpaired analyses of different cohorts. Results: Sample type (oral vs fecal) and nuclear family unit were the two most predominant variables explaining variance in microbiome diversity, more so than having a diagnosis of JDM. The oral and gut microbiomes of JDM probands were more similar to their own unaffected siblings than they were to the microbiomes of other JDM probands. Nonetheless, in a sibling-paired analysis, several potentially immunomodulatory bacterial taxa were differentially abundant in the microbiomes of JDM probands compared to their unaffected siblings, including Faecalibacterium in the gut and Streptococcus in the oral cavity. Further, compared to published microbiome datasets generated from healthy children and adults, fecal microbiomes of both JDM probands and their unaffected family members were markedly different. Conclusions: Family unit (which reflects the confluence of genetic and household effects) has a significant effect on microbiome community structure. Features of the dysbioses seen in oral and fecal microbiomes of JDM probands were shared by their unaffected family members, suggesting familial microbiome signatures. The loss or gain of specific fecal and oral bacteria may potentially play a role in disease pathogenesis and/or be secondary to immune dysfunction in susceptible individuals.
Efficacy, tolerability and safety evaluation of atypical antipsychotics in the treatment of behavioral and psychological symptoms of dementia-a Bayesian network meta-analysis
Authors: gu rui , Xu Wu , Zhao Xiaoling , Liu Yan 
Published: August 2022

Abstract
Introduction: Atypical antipsychotics (AAPs) are commonly used for patients with behavioral and psychological symptoms of dementia (BPSD). But conclusion of efficacy, tolerability and safety is uncertainty. Hence, we compared the efficacy, tolerability and safty of AAPs for BPSD.Methods: We searched randomized controlled trials (RCTs). The primary outcome were the changes of Neuropsychiatric Inventory (NPI) total score, NPI-psychosis total score and the tolerability. The secondary outcome were the changes in the Brief Psychiatric Rating Scale (BPRS) total score, Cohen-Mansfield Agitation Inventory (CMAI) total score. We also evaluated 12 safety outcome measures. Then a Bayesian network meta-analyses was conducted.Results: There was no statistically significant difference between these AAPs and placebo or between AAPs either on effective outcome measures. Olanzapine had more worse tolerability, higher risk of CVAEs and EPSs, greater change of body weight compared with placebo. Risperidone had higher risk of EPSs and peripheral edema than placebo. Aripiprazole, olanzapine, quetiapine and risperidone all had higher risk of somnolence or sedation than placebo..Conclusions: There is no absolutely effective, tolerability and safe AAPs for BPSD. Doctors should weigh the advantages and disadvantages of each AAPS, select the drugs individually and closely monitor the adverse reactions during the treatment.
Effect of an emotional intelligence educational program on perceived and occupational stress of health personnel: a pragmatic cluster randomized controlled trial
Authors: Heydarifard Maryam , Rakhshani Tayebeh , Fararoie Mohammad , Khafaie Morteza Abdullatif 
Published: August 2022

Abstract
Background
coping with occupational stress is vital for health personnel to communicate more with patients and ultimately the interactions between patients and providers impact the quality of care. The current study aimed to investigate the effect of the emotional intelligence training program (EITP) on occupational and perceived stress in health personnel.
Methods
A pragmatic cluster randomized controlled trial study was conducted in Andimeshk Health Centers, located in the northwest Khuzestan province between January and March 2019. Absolute change from baseline to final emotional intelligence (EI), occupational stress (OS), and perceived stress (PS), were measured. Standard questionnaires including Brad-berry & Graves Emotional Intelligence Questionnaire (2004), HSE (UK Health and Safety Executive) Standard Occupational Stress Questionnaire, and Brad-berry's, Cohen's perceived stress, were used. The in-person training program includes two workshops (duration = 6 hours) and a 30-day follow-up.
Results
Out of 80 health personnel, 75 fulfilled the study requirement. (n = 37 allocated into the experiment vs n = 38 control). Baseline emotional intelligence in the experiment group was improved by about 1.16 units versus a non-significant change in the control group (=-1.21). At baseline, there was no significant difference between the experiment and control groups in terms of mean score of OS and PS (p > 0.05). We have observed a non-significant improvement in the experiment group in terms of OS and PS. However, the score changes in the experiment group were significantly higher than in the control group (P < 0.05).
Conclusion
We have shown emotional intelligence improvement could have a significant impact on stress management as so recommended to include EI training in the annual training programs.
Trial registration:
RCT: IRCT20160418027449N4 Date: 25/02/2019
Effects of CEM cement and Emdogain on proliferation and differentiation of human stem cells from the apical papilla: A Comparative In Vitro Study
Authors: Khoshbin Elham , Ghasemi Leila , Najafi Rezvan , Karkehabadi Hamed 
Published: August 2022

Abstract
Objectives: This study compared the effects of calcium-enriched mixture (CEM) cement, Emdogain, and their combination (CEM/Emdogain) on differentiation and proliferation of stem cells from the apical papilla (SCAPs). Methods: In this in vitro, experimental study, SCAPs were isolated from two sound immature impacted third molars and cultured. After ensuring their stemness by detecting cell surface markers they were exposed to CEM cement, Emdogain, and CEM cement coated with Emdogain for 24 and 72 hours. The control cells did not undergo any intervention. Cell viability [by methyl thiazolyl tetrazolium (MTT) assay], expression of odontogenic differentiation genes [by quantitative reverse-transcription polymerase chain reaction (qRT-PCR)] and alkaline phosphatase (ALP) activity (by ALP staining kit) were evaluated. Data were analyzed by one-way ANOVA, t-test, and Mann-Whitney test (α=0.05). Results: Cell viability in the CEM cement and CEM/Emdogain groups decreased compared with the control group at 72 hours (P<0.05). Expression of dentin sialophosphoprotein (DSPP), dentin matrix protein 1 (DMP1), bone sialoprotein (BSP) genes and ALP activity significantly increased in all three experimental groups compared with the control group at both 24 and 72 hours. This increase was substantially more significant in CEM/Emdogain group (P>0.05). The number of mineralized nodules significantly increased in all groups at 72 hours, with a higher rate in the CEM/Emdogain group. Conclusion: All biomaterials increased the differentiation of SCAPs, expression of odontogenic differentiation genes, and ALP activity, but CEM/Emdogain was considerably more effective for this purpose.
Molecular Characterization and Morphological Variation of Various Fusarium spp. Associated with Post Flowering Stalk Rot of Maize in India
Authors: YADAV KALPANA , SHARMA S. S. , KHOKHAR M. K. 
Published: August 2022

Abstract
Maize (Zea mays L.) is the vital cereal crop around the world and is the third wide grown cereal crop in India for food grain purposes. Field surveys were conducted from 2019–2020 recorded stalk rot incidence ranged from 23–50% in several maize growing districts of Southern Rajasthan, India. On the basis of primary symptoms, typical symptoms were observed after flowering season and it starts with the drying of the lower leaves and premature wilting, internal decay and discoloration of stalk tissue, lower internodes turned into grey-green color and stalks are hollow and weak leading to the lodging of the plant and directly reducing maize yield. We identified associated pathogens with post flowering stalk rot disease severity and incidence and Fusarium considered as major threat in all the maize growing regions. Consequently, in this research, identification was confirmed as “Fusarium spp”. by morphological and molecular sequence analysis. “Fusarium” species associated with stalk rot incidence were isolated on PDA. No. of 12 fungal isolates were isolated from Post Flowering Stalk Rot complex from different localities. All Isolates were identified as Fusarium, based on colony character, conidial and morphological characters. However, identification of 10 primarily selected isolates of Fusarium was confirmed by molecular characterization. Based on morphological characteristics, 10 isolates were classified as F. verticillioides (5 isolates) and 2 isolates as Fusarium proliferatum, 1 isolate of Fusarium luffae, 1 isolate of Fusarium pallidoroseum and 1 isolate of Fusarium oxysporum. Colony diameter of isolates ranged between 65.80 to 90 mm. All the ten isolates of Fusarium spp. showed notable variations in conidial morphology. Molecular variability of the ten isolates was carried out by choosing 10 RAPD markers of Operon series. Ten primers produced scorable bands with high percentage of the polymorphism (91.1%). Similarity coefficient among all these isolates of Fusarium spp. based on amplifying DNA using RAPD primers was estimated using Jaccard coefficient of similarity and thus similarity matrix was generated (62.5–85.4%). Dendrogram was constructed based on molecular data generated by 10 RAPD primers using NTSYS Pc (numerical taxonomic and multivariate analysis system) version 2.02.e UPGMA clusters analysis grouped Fusarium spp. isolates into two clusters with 0.32% similarity coefficient.
Targeting regulation of VEGF by BPTF in Non-Small Cell Lung Cancer and its potential clinical significance
Authors: Dai Meng , Hua Chunyu , Wang Mingqin , Gao Li , Jiang Ling , Liu Yuan 
Published: August 2022

Abstract
Purpose
VEGF facilitates the formation of tumor angiogenesis, and bevacizumab targeting VEGF is used in anti-tumor therapy. It’s meaningful to clarify the upstream regulatory mechanism of VEGF. BPTF is important in chromosomal remodeling, and promotes the progression of tumors. However, its promotion of tumor angiogenesis by targeting VEGF has not been reported. This study aims to elucidate the regulation of VEGF by BPTF and its clinical significance in NSCLC.
Methods
1. Reduced the expression of BPTF by transfecting BPTF siRNA and shRNA plasmid in vivo and vitro. Examined the expressions of BPTF, VEGF and CD144 by immunofluorescence and Western Blot. 2. The expressions of BPTF, VEGF, CD144 and CD31 were detected in lung adenocarcinoma samples by immunofluorescence, Western Blot and immunohistochemical. 3. 26 lung adenocarcinoma patients treated by bevacizumab were divided into 2 groups according to the bevacizumab efficacy. BPTF and VEGF expressions were analyzed.
Results
1. BPTF knockdown can inhibit the expression of VEGF and CD144 in vivo and vitro. 2. Compared with para-cancer tissues, BPTF, VEGF, CD144 and CD31 were highly expressed in lung adenocarcinoma. 3. In 75 lung adenocarcinoma specimens, BPTF and VEGF overexpression was correlated with lymph node metastasis and clinical stage. The five-year survival rate in group of BPTF and VEGF low expression was higher, and BPTF was positively correlated with VEGF. 4. Among 26 patients treated with bevacizumab, the patients with BPTF overexpresstion are more in the sensitive group.
Conclusions
BPTF positively regulates VEGF expression and BPTF predicts a better efficacy of bevacizumab in NSCLC.
Health-related Quality of Life Among Adult Patients With Cancer in Uganda
Authors: Naamala Allen , Eriksson Lars E. , Orem Jackson , Nalwadda Gorrette K. , Kabir Zarina Nahar , Wettergren Lena 
Published: August 2022

Abstract
Aim: To investigate prevalence of clinical cases with regard to health-related quality of life (HRQoL) and its association with socio-demographic and clinical factors among adult patients attending specialized cancer care in Uganda. Methods: A cross-sectional study assessed HRQoL in 385 patients (response rate 95%) using the EORTC QLQ-C30. Predetermined thresholds indicating clinical importance were applied to identify patients exhibiting functional impairments and symptoms at a level meriting concern (clinical case). Multivariable logistic regression models identified factors associated with being a clinical case in selected subscales of the EORTC QLQ-C30. Results: The majority of the patients (mean age 48 years) reported functioning at levels indicating clinical caseness (68%−87%), as well as significant pain (80%), and fatigue (63%). Higher age and lack of education were associated with clinical caseness. Clinical characteristics related to caseness included having an advanced disease stage, being hospitalized, receiving palliation, not on active cancer treatment as well as diagnosed with head/neck cancers. Conclusion: The study demonstrated that more than two thirds of adult patients cared for at a specialized cancer facility in Uganda rate HRQoL at levels meriting concern. The large proportion of patients with pain calls for implementation of guidelines to improve pain management.
Nursing experience during COVID-19 pandemic in Korea: A qualitative analysis based on the Professional Practice Model
Authors: Kim Hye-Ryoung , Yang Hwa-Mi 
Published: August 2022

Abstract
Background
Nurses have an essential role and responsibility to work at the forefront of patient care during the COVID-19 pandemic. Although the press and public have praised the dedication of nurses in the COVID-19 pandemic, there are several points to consider for nursing professional development. The purpose of this study is to collect the experiences of the nursing profession in the COVID-19 pandemic through interviews, seek improvements for the development of the nursing profession, and suggest directions for the future.
Method
This qualitative study adopts semi-structured interviews analyzing the nursing experience of the COVID-19 pandemic based on the professional practice models (PPMs). Ten nurses with at least two years of working experience and thorough work changes in the COVID-19 pandemic from various settings have participated in the study
Results
We identified thirty-nine problematic codes and nineteen improvement codes which mapped to 12 key concepts and corresponded to 6 constructs of the PPM model.
Conclusions
Nurses had to take on tasks beyond their duties in urgent situations, which restrained nurses from concentrating on their work. Clarifying working boundaries is fundamental for collaborative care and independent nursing practice. Collaboration and communication among healthcare workers based on mutual understanding can create a respectful working environment. Although there were many difficulties due to the uncertain situation, we can find that the nursing profession can make achievements through systematic and organizational support for sticking to the basics of nursing, securing technical expertise, cultivating critical thinking, and developing various professional attributes. In this way, the establishment of roles based on professional values and duties and the ascertainment of clear boundaries for nursing will ultimately help to improve the quality of patient care.
Strain-level structure of gut microbiome associated with the cognitive function in major depressive disorder
Authors: Dong Zaiquan , Xie Qinglian , Shen Xiaoling , Hao Yanni , Li Jin , Xu Haizheng , Kuang Weihong 
Published: August 2022

Abstract
Background
Although the association between gut microbiota and the pathogenesis of major depressive disorder (MDD) has been well studied, it is unclear whether the gut microbiota affects cognitive function in patients with MDD. Based on a strain-level analysis, we explored the impact of gut microbiota on cognitive function in MDD and possible mechanisms.
Methods
We enrolled 57 patients with MDD and 30 healthy controls (HCs) in this study and used 16S rRNA gene sequencing analysis to determine gut microbial composition. Untargeted metabolite analyses were used to assess differences in metabolites between the two groups. A bespoke neuropsychological test suite was used to test the cognitive function of patients with MDD.
Results
We found that the richness and diversity of gut microbiota in patients with MDD was the same as that in HCs, but there were differences in the abundance of Bifidobacterium and Blautia. Compared with HCs, three strains (bin_31, bin_32, and bin_55) were significantly increased in patients with MDD base on the strain-level meta-analysis. We found time to complete the Stroop-C had a significant negative correlation with bin_31 and bin_32 (both P < 0.05). Bin_55 had a significant negative correlation with time to complete the Stroop-C, time to complete the Stroop-CW, and repeated animal words in 60 seconds, but a significant positive correlation with correct answers in 120s on the Stroop-CW (all P < 0.05). Co-occurrence network analysis showed that bin_31 had a significant negative correlation with Cer(d14:2(4E,6E)/22:0(2OH)) (P < 0.01). In addition, bin_55 had a significant positive correlation with Capsanthin 5,6-epoxide and a negative correlation with 5-Hepteneoylglycine, and bin_32 had a significant positive correlation with 6-Gingerol and Montecristin and negative correlation with 5-Hepteneoylglycine and 12-HETE-GABA (all P < 0.05)
Conclusions
In the present study, we found a significant correlation between several strains of gut microbes (bin_31, bin_32, and bin_55) and cognitive function in patients with MDD. This provides a new basis for the treatment of MDD by intervening with the gut microbiome.
The relationship between exogenous progesterone administration in the first- trimester pregnancy and fetal nuchal translucency thickness
Authors: Mahmoodian Bahareh , Zare Shamsi , Seydoshohadaei Fariba , Rahmani Khaled , Zandvakili Farnaz 
Published: August 2022

Abstract
Introduction: Increased fetal nuchal translucency (NT) thickness is defined as a transient subcutaneous accumulation of fluid behind the fetal neck that can be seen with the help of ultrasound. The thickness of fetal NT is a diagnostic criterion in genetic syndromes. The aim of this study was to investigate the relationship between exogenous progesterone administration in the first trimester of pregnancy and fetal NT thickness.Materials and Methods: This retrospective cohort study was conducted on 200 pregnant women aged 18 to 45 years including 100 pregnant women receiving exogenous progesterone due to vaginal bleeding in the first trimester and 100 pregnant women who did not receive exogenous progesterone from February 2021 to November 2021. The NT thickness of their fetal was measured at 11 to 12 weeks-6 days of gestation. Data were analyzed using Stata software version 14 using independent t-test, Chi-square, Fisher, and Pearson correlation coefficient. The statistical significance level was determined as less than 0.05 (P <0.05).Results: Mean of age, body mass index (BMI), gestational age (GA), crown-rump length (CRL), pregnancy-associated plasma protein-A (PAPP-A), free beta-human chorionic gonadotropin (FβHCG) and βHCG median and multiple of median (MOM) levels were not statistically significant in the two groups (p<0.05).The mean of NT thickness in the group receiving exogenous progesterone was higher than the group non-receiving exogenous progesterone and there was a significant difference between the two groups (p<0.05). Frequency distribution of Gravida, parity, previous live births, previous abortion, and history of abnormalities were not significant in the two groups (p<0.05). Conclusion: Although the findings of the present study showed that external progesterone consumption increased the thickness of the fetal nuchal translucency thickness, no anomaly was observed in delivered babies.