bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sediment Load and Grain Size Controls on Channel Migration Patterns in Experimental Deltas
Authors: Cazanacli Dan , Paola Chris , Singh Arvind 
Published: May 2022

AbstractUnderstanding channel migration is essential in interpreting long‐term evolution of fluvial systems and their deposits. Using data from an experimental delta, we analyzed the kinematics of the upstream channel and assessed the relative dominance of continuous lateral channel migration versus abrupt changes (i.e., avulsions). Detailed investigation of channel centerline location at minute intervals reveals a short‐term correlation between the magnitude of migration rates measured at the same location and a spatial correlation that diminishes with distance between points. The main finding is that the channel migrates across the entire deltaic domain without large and abrupt lateral shifts but through continuous lateral migration at variable rates. Long periods of back and forth small moves are separated by short bursts of rapid lateral migration. This finding contradicts the default expectation that that aggrading systems are characterized by avulsions and suggests that highly mobile rivers tend to avulse less. We contrast this with another experiment conducted under similar conditions but with finer sediment supplied at a lower rate which shows drastically less lateral migration; the kinematics is instead dominated by periodic flow reconfiguration episodes akin to avulsions, an indication that channel migration‐style depends on the sediment load. The characteristics of these two experiments parallel two regions of the Mississippi River, the meandering and highly mobile alluvial plain and the less dynamic deltaic region, suggesting that bedload sediment deposition at the transition into backwater zone plays an important role in re‐shaping the river planform and migration style.
Impacts of the January 2022 Tonga Volcanic Eruption on the Ionospheric Dynamo: ICON‐MIGHTI and Swarm Observations of Extreme Neutral Winds and Currents
Authors: Harding Brian J. , Wu Yen‐Jung Joanne , Alken Patrick , Yamazaki Yosuke , Triplett Colin C. , Immel Thomas J. , Gasque L. Claire , Mende Stephen B. , Xiong Chao 
Published: May 2022

AbstractThe eruption of the Hunga Tonga‐Hunga Ha'apai volcano on 15 January 2022 triggered atmospheric waves at all altitudes. The National Aeronautics and Space Administration Ionospheric Connection Explorer (ICON) and European Space Agency Swarm satellites were well placed to observe its impact on the ionospheric wind dynamo. After the Lamb wave entered the dayside, Swarm A observed an eastward and then westward equatorial electrojet (EEJ) on two consecutive orbits, each with magnitudes exceeding the 99.9th percentile of typically observed values. ICON simultaneously observed the neutral wind (90–300 km altitude) at approximately the same distance from Tonga. The observed neutral winds were also extreme (>99.9th percentile at some altitudes). The covariation of EEJ and winds is consistent with recent theoretical and observational results, indicating that the westward electrojet is driven by strong westward winds in the Pedersen region (∼120–150 km). These observations imply that the dynamo is a key mechanism in the ionospheric response to the Tonga disturbance.
Plant Proxy Evidence for High Rainfall and Productivity in the Eocene of Australia
Authors: Reichgelt Tammo , Greenwood David R. , Steinig Sebastian , Conran John G. , Hutchinson David K. , Lunt Daniel J. , Scriven Leonie J. , Zhu Jiang 
Published: May 2022

AbstractDuring the early to middle Eocene, a mid‐to‐high latitudinal position and enhanced hydrological cycle in Australia would have contributed to a wetter and “greener” Australian continent where today arid to semi‐arid climates dominate. Here, we revisit 12 southern Australian plant megafossil sites from the early to middle Eocene to generate temperature, precipitation, and seasonality paleoclimate estimates, net primary productivity (NPP), and vegetation type, based on paleobotanical proxies and compare them to early Eocene global climate models. Temperature reconstructions are uniformly subtropical (mean annual, summer, and winter mean temperatures 19–21°C, 25–27°C, and 14–16°C, respectively), indicating that southern Australia was ∼5°C warmer than today, despite a >20° poleward shift from its modern geographic location. Precipitation was less homogeneous than temperature, with mean annual precipitation of ∼60 cm over inland sites and >100 cm over coastal sites. Precipitation may have been seasonal with the driest month receiving 2–7× less than the mean monthly precipitation. Proxy‐model comparison is favorable with a 1,680 ppm CO2 concentration. However, individual proxy reconstructions can disagree with models as well as with each other. In particular, seasonality reconstructions have systemic offsets. NPP estimates were higher than modern, implying a more homogenously “green” southern Australia in the early to middle Eocene when this part of Australia was at 48–64°S and larger carbon fluxes to and from the Australian biosphere. The most similar modern vegetation type is modern‐day eastern Australian subtropical forest, although the distance from coast and latitude may have led to vegetation heterogeneity.
Detoxified pneumolysin derivative ΔA146Ply inhibits autophagy and induces apoptosis in acute myeloid leukemia cells by activating mTOR signaling
Authors: Zhu Tao , Zhang Hong , Li Sijie , Wu Kaifeng , Yin Yibing , Zhang Xuemei 
Published: May 2022

AbstractLeukemia is caused by the malignant clonal expansion of hematopoietic stem cells, and in adults, the most common type of leukemia is acute myeloid leukemia (AML). Autophagy inhibitors are often used in preclinical and clinical models in leukemia therapy. However, clinically available autophagy inhibitors and their efficacy are very limited. More effective and safer autophagy inhibitors are urgently needed for leukemia therapy. In a previous study, we showed that ΔA146Ply, a mutant of pneumolysin that lacks hemolytic activity, inhibited autophagy of triple-negative breast cancer cells by activating mannose receptor (MR) and toll-like receptor 4 (TLR4) and that tumor-bearing mice tolerated ΔA146Ply well. Whether this agent affects AML cells expressing TLR4 and MR and the related mechanisms remain to be determined. In this study, we found that ΔA146Ply inhibited autophagy and induced apoptosis in AML cells. A mechanistic study showed that ΔA146Ply inhibited autophagy by activating mammalian target of rapamycin signaling and induced apoptosis by inhibiting autophagy. ΔA146Ply also inhibited autophagy and induced apoptosis in a mouse model of AML. Furthermore, the combination of ΔA146Ply and chloroquine synergistically inhibited autophagy and induced apoptosis in vitro and in vivo. Overall, this study provides an alternative effective autophagy inhibitor that may be used for leukemia therapy.
Genetic evidence for a potential causal relationship between insomnia symptoms and suicidal behavior: a Mendelian randomization study
Authors: Nassan Malik , Daghlas Iyas , Winkelman John W. , Dashti Hassan S. ,   International Suicide Genetics Consortium, Saxena Richa 
Published: May 2022

AbstractInsomnia and restless leg syndrome (RLS) are associated with increased risk for suicidal behavior (SB), which is often comorbid with mood or thought disorders; however, it is unclear whether these relationships are causal. We performed a two-sample Mendelian randomization study using summary-level genetic associations with insomnia symptoms and RLS against the outcomes of risk of major depressive disorder (MDD), bipolar disorder (BP), schizophrenia (SCZ), and SB. The inverse-variance weighted method was used in the main analysis. We performed replication and sensitivity analyses to examine the robustness of the results. We identified outcome cohorts for MDD (n = 170,756 cases/329,443 controls), BP (n = 20,352/31,358), SCZ (n = 69,369/236,642), SB-Cohort-2019 (n = 6569/14,996 all with MDD, BP or SCZ; and SB within individual disease categories), and SB-Cohort-2020 (n = 29,782/519,961). Genetically proxied liability to insomnia symptoms significantly associated with increased risk of MDD (odds ratio (OR) = 1.23, 95% confidence interval (CI) = 1.2–1.26, P = 1.37 × 10–61), BP (OR = 1.15, 95% CI = 1.07–1.23, P = 5.11 × 10–5), SB-Cohort-2019 (OR = 1.17, 95% CI = 1.07–1.27, P = 2.30 × 10–4), SB-Cohort-2019 in depressed patients (OR = 1.34, 95% CI = 1.16–1.54, P = 5.97 × 10–5), and SB-Cohort-2020 (OR = 1.24, 95% CI = 1.18–1.3, P = 1.47 × 10–18). Genetically proxied liability to RLS did not significantly influence the risk of any of the outcomes (all corrected P > 0.05). Results were replicated for insomnia with MDD and SB in Mass General Brigham Biobank and were consistent in multiple lines of sensitivity analyses. In conclusion, human genetic evidence supports for the first time a potentially independent and causal effect of insomnia on SB and encourages further clinical investigation of treatment of insomnia for prevention or treatment of SB.
Treosulfan plus fludarabine versus TEAM as conditioning treatment before autologous stem cell transplantation for B-cell Non-Hodgkin lymphoma
Authors: Frietsch Jochen J. , Miethke Jenny , Linke Paul , Crodel Carl C. , Schnetzke Ulf , Scholl Sebastian , Hochhaus Andreas , Hilgendorf Inken 
Published: May 2022

AbstractConditioning with treosulfan and fludarabine (Treo/Flu) has been proven to be feasible and efficient in several types of malignancies before allogeneic hematopoietic stem cell transplantation (allo-HSCT). Given its favorable reduced toxicity profile, we introduced Treo/Flu as conditioning before autologous HSCT (auto-HSCT) in patients with B-cell Non-Hodgkin lymphoma (NHL). The aim of this study was to evaluate the efficacy and safety of Treo/Flu in comparison to TEAM. Fifty-seven patients with NHL received auto-HSCT after conditioning with either Treo/Flu (n = 22) or TEAM (n = 35). All patients achieved sustained engraftment. PFS, EFS and OS were not significant in both groups. Of note is that patients in the Treo/Flu group were less dependent on thrombocyte transfusions (p = 0.0082), significantly older (in median 11 years, p < 0.0001) and suffered less frequently from infectious complications (p = 0.0105), mucositis and stomatitis (p < 0.0001). This study is the first to present efficacy, feasibility, and safety of conditioning with Treo/Flu preceding auto-HSCT in patients with NHL. Since it demonstrated a lack of significant difference in comparison to TEAM conditioning it might be a valuable alternative especially in elderly patients with B-cell NHL and comorbidities. Further evaluation by prospective clinical trials is warranted.
Modeling transmission of SARS-CoV-2 Omicron in China
Authors: Cai Jun , Deng Xiaowei , Yang Juan , Sun Kaiyuan , Liu Hengcong , Chen Zhiyuan , Peng Cheng , Chen Xinhua , Wu Qianhui , Zou Junyi , Sun Ruijia , Zheng Wen , Zhao Zeyao , Lu Wanying , Liang Yuxia , Zhou Xiaoyu , Ajelli Marco , Yu Hongjie 
Published: May 2022

AbstractHaving adopted a dynamic zero-COVID strategy to respond to SARS-CoV-2 variants with higher transmissibility since August 2021, China is now considering whether, and for how long, this policy can remain in place. The debate has thus shifted towards the identification of mitigation strategies for minimizing disruption to the healthcare system in the case of a nationwide epidemic. To this aim, we developed an age-structured stochastic compartmental susceptible-latent-infectious-removed-susceptible model of SARS-CoV-2 transmission calibrated on the initial growth phase for the 2022 Omicron outbreak in Shanghai, to project COVID-19 burden (that is, number of cases, patients requiring hospitalization and intensive care, and deaths) under hypothetical mitigation scenarios. The model also considers age-specific vaccine coverage data, vaccine efficacy against different clinical endpoints, waning of immunity, different antiviral therapies and nonpharmaceutical interventions. We find that the level of immunity induced by the March 2022 vaccination campaign would be insufficient to prevent an Omicron wave that would result in exceeding critical care capacity with a projected intensive care unit peak demand of 15.6 times the existing capacity and causing approximately 1.55 million deaths. However, we also estimate that protecting vulnerable individuals by ensuring accessibility to vaccines and antiviral therapies, and maintaining implementation of nonpharmaceutical interventions could be sufficient to prevent overwhelming the healthcare system, suggesting that these factors should be points of emphasis in future mitigation policies.
Estimating ranibizumab injection numbers and visual acuity at 12 months based on 2-month data on branch retinal vein occlusion treatment
Authors: Murata Toshinori , Kondo Mineo , Inoue Makoto , Nakao Shintaro , Osaka Rie , Shiragami Chieko , Sogawa Kenji , Mochizuki Akikazu , Shiraga Rumiko , Kaneko Takeumi , Chandrasekhar Chikatapu , Tsujikawa Akitaka , Kamei Motohiro 
Published: May 2022

AbstractAnti-vascular endothelial growth factor treatment for macular edema secondary to branch retinal vein occlusion generally provides good visual acuity (VA) improvement but may require repeated injections for years. To reduce the number of patients who suffer from avoidable VA loss caused by treatment drop-out, providing prospects of the correlation between expected vision improvement and required number of injections at the early stages of treatment may be helpful. In this post hoc analysis of the phase IV, randomized, open-label ZIPANGU study, we investigated the correlation between the data from Month 2 and Month 12 in terms of VA and required ranibizumab injection numbers. Fifty-nine patients were evaluated (ranibizumab monotherapy, 29; combination therapy, 30). In the monotherapy group, patients who received 1 and 3 injections by Month 2 received a mean total of 2.8 and 8.3 injections during the year, respectively. Data from the combination group were similar. The correlation coefficients for VA scores at Months 2 and 12 were 0.60 and 0.51 for the monotherapy and combination groups, respectively (both p < 0.01). Based on VA and injection numbers at Month 2 of treatment, physicians could provide rough prospects on patients’ expected final VA and required number of injections.
The field of expertise modulates the time course of neural processes associated with inhibitory control in a sport decision-making task
Authors: Simonet Marie , Ruggeri Paolo , Sallard Etienne , Barral Jérôme 
Published: May 2022

AbstractInhibitory control (IC), the ability to suppress inappropriate actions, can be improved by regularly facing complex and dynamic situations requiring flexible behaviors, such as in the context of intensive sport practice. However, researchers have not clearly determined whether and how this improvement in IC transfers to ecological and nonecological computer-based tasks. We explored the spatiotemporal dynamics of changes in the brain activity of three groups of athletes performing sport-nonspecific and sport-specific Go/NoGo tasks with video footages of table tennis situations to address this question. We compared table tennis players (n = 20), basketball players (n = 20) and endurance athletes (n = 17) to identify how years of practicing a sport in an unpredictable versus predictable environment shape the IC brain networks and increase the transfer effects to untrained tasks. Overall, the table tennis group responded faster than the two other groups in both Go/NoGo tasks. The electrical neuroimaging analyses performed in the sport-specific Go/NoGo task revealed that this faster response time was supported by an early engagement of brain structures related to decision-making processes in a time window where inhibition processes typically occur. Our collective findings have relevant applied perspectives, as they highlight the importance of designing more ecological domain-related tasks to effectively capture the complex decision-making processes acquired in real-life situations. Finally, the limited effects from sport practice to laboratory-based tasks found in this study question the utility of cognitive training intervention, whose effects would remain specific to the practice environment.
Impact of fasting on stress systems and depressive symptoms in patients with major depressive disorder: a cross-sectional study
Authors: Stapel Britta , Fraccarollo Daniela , Westhoff-Bleck Mechthild , Bauersachs Johann , Lichtinghagen Ralf , Jahn Kirsten , Burkert Alexandra , Buchholz Vanessa , Bleich Stefan , Frieling Helge , Ding Xiao-Qi , Kahl Kai G. 
Published: May 2022

AbstractMajor depressive disorder (MDD) is frequently associated with poor response to treatment. Common antidepressants target neurotransmission and neuronal plasticity, which require adequate energy supply. As imaging studies indicate disturbances in central energy metabolism, and caloric restriction improves neuroplasticity and impacts mood and cognition, correction of energy status might increase the effectiveness of antidepressant treatments and reduce the psychopathological symptoms of depression. Metabolic parameters, stress hormones, and brain-derived neurotrophic factor (BDNF) levels were assessed in serum of depressed inpatients (MDD, N = 21) and healthy volunteers (Ctrl, N = 28) before and after a 72 h fasting period during which only water was consumed. Depression severity was assessed by Beck’s Depression Inventory (BDI)-2 sum-score and cognitive-affective and somatic sub-scores. Fasting similarly impacted metabolic parameters and stress systems in both groups. Fasting elevated BDI-2 sum-scores and somatic sub-scores in Ctrl. In MDD, fasting increased somatic-, but decreased cognitive-affective symptoms. Sub-group analyses based on BDI-2 sum-scores pre-fasting showed that cognitive-affective symptoms decreased in patients with moderate/severe but not in those with mild symptoms. This was associated with differential changes in BDNF levels. In conclusion, fasting improved cognitive-affective sub-scores in MDD patients with moderate/severe symptoms that had not responded to prior therapy. Interventions that modulate energy metabolism might directly improve cognitive-affective symptoms and/or augment therapeutic efficacy in moderate-to-severely depressed patients.
Event-driven proto-object based saliency in 3D space to attract a robot’s attention
Authors: Ghosh Suman , D’Angelo Giulia , Glover Arren , Iacono Massimiliano , Niebur Ernst , Bartolozzi Chiara 
Published: May 2022

AbstractTo interact with its environment, a robot working in 3D space needs to organise its visual input in terms of objects or their perceptual precursors, proto-objects. Among other visual cues, depth is a submodality used to direct attention to visual features and objects. Current depth-based proto-object attention models have been implemented for standard RGB-D cameras that produce synchronous frames. In contrast, event cameras are neuromorphic sensors that loosely mimic the function of the human retina by asynchronously encoding per-pixel brightness changes at very high temporal resolution, thereby providing advantages like high dynamic range, efficiency (thanks to their high degree of signal compression), and low latency. We propose a bio-inspired bottom-up attention model that exploits event-driven sensing to generate depth-based saliency maps that allow a robot to interact with complex visual input. We use event-cameras mounted in the eyes of the iCub humanoid robot to directly extract edge, disparity and motion information. Real-world experiments demonstrate that our system robustly selects salient objects near the robot in the presence of clutter and dynamic scene changes, for the benefit of downstream applications like object segmentation, tracking and robot interaction with external objects.
Epidemiology of accelerometer-based sleep parameters in US school-aged children and adults: NHANES 2011–2014
Authors: Su Shaoyong , Li Xinyue , Xu Yanyan , McCall William V. , Wang Xiaoling 
Published: May 2022

AbstractWe aimed to provide objectively measured sleep parameters across lifespan by sex and race in a national representative sample of US population. The study included 11,279 participants 6 years and older from the National Health and Nutrition Examination Survey (NHANES) 2011–2014, who had at least 3 days of valid sleep parameters calculated from 7-day 24-h accelerometer recording. Sleep duration showed a U-shaped association with age and reached the minimum at age 40 and started to increase again around age 50. The clock time for sleep onset (CTSO) delayed with age and reached the maximum at about age 20. CTSO then advanced until age 50, leveled off until age 70, then advanced again after age 70. Sleep efficiency showed an overall decreasing trend across the lifespan but stabilized from age 30 to about age 60. US young adults in age 20 s are the ones who slept at the latest around midnight, while the middle aged US residents between 40 and 50 years old slept the least. Females generally present longer sleep duration than males, while more likely to have later sleep onset, particularly at older ages. Non-Hispanic Blacks showed worse sleep characteristics, i.e. sleep later, sleep shorter, and sleep less efficiently, compared to other racial groups. In conclusion, this study provides valuable insights on the characteristics of sleep habits of residents of the United States by using objectively measurements of sleep parameters and will help guide personalized advice on sleep hygiene.
Pervasive male-biased expression throughout the germline-specific regions of the sea lamprey genome supports key roles in sex differentiation and spermatogenesis
Authors: Yasmin Tamanna , Grayson Phil , Docker Margaret F. , Good Sara V. 
Published: May 2022

AbstractSea lamprey undergo programmed genome rearrangement (PGR) in which ∼20% of the genome is jettisoned from somatic cells during embryogenesis. Although the role of PGR in embryonic development has been studied, the role of the germline-specific region (GSR) in gonad development is unknown. We analysed RNA-sequence data from 28 sea lamprey gonads sampled across life-history stages, generated a genome-guided de novo superTranscriptome with annotations, and identified germline-specific genes (GSGs). Overall, we identified 638 GSGs that are enriched for reproductive processes and exhibit 36x greater odds of being expressed in testes than ovaries. Next, while 55% of the GSGs have putative somatic paralogs, the somatic paralogs are not differentially expressed between sexes. Further, putative orthologs of some the male-biased GSGs have known functions in sex determination or differentiation in other vertebrates. We conclude that the GSR of sea lamprey plays an important role in testicular differentiation and potentially sex determination.