bluuebunny/crossref_metadata_2025_split huggingface dataset:
Observation-based modelling of the energetic storm particle event of 14 July 2012
Authors: Wijsen N. , Aran A. , Scolini C. , Lario D. , Afanasiev A. , Vainio R. , Sanahuja B. , Pomoell J. , Poedts S. 
Published: January 2022

Aims. We model the energetic storm particle (ESP) event of 14 July 2012 using the energetic particle acceleration and transport model named ‘PArticle Radiation Asset Directed at Interplanetary Space Exploration’ (PARADISE), together with the solar wind and coronal mass ejection (CME) model named ‘EUropean Heliospheric FORcasting Information Asset’ (EUHFORIA). The simulation results illustrate both the capabilities and limitations of the utilised models. We show that the models capture some essential structural features of the ESP event; however, for some aspects the simulations and observations diverge. We describe and, to some extent, assess the sources of errors in the modelling chain of EUHFORIA and PARADISE and discuss how they may be mitigated in the future.
Methods. The PARADISE model computes energetic particle distributions in the heliosphere by solving the focused transport equation in a stochastic manner. This is done using a background solar wind configuration generated by the ideal magnetohydrodynamic module of EUHFORIA. The CME generating the ESP event is simulated by using the spheromak model of EUHFORIA, which approximates the CME’s flux rope as a linear force-free spheroidal magnetic field. In addition, a tool was developed to trace CME-driven shock waves in the EUHFORIA simulation domain. This tool is used in PARADISE to (i) inject 50 keV protons continuously at the CME-driven shock and (ii) include a foreshock and a sheath region, in which the energetic particle parallel mean free path, λ∥, decreases towards the shock wave. The value of λ∥ at the shock wave is estimated from in situ observations of the ESP event.
Results. For energies below ∼1 MeV, the simulation results agree well with both the upstream and downstream components of the ESP event observed by the Advanced Composition Explorer. This suggests that these low-energy protons are mainly the result of interplanetary particle acceleration. In the downstream region, the sharp drop in the energetic particle intensities is reproduced at the entry into the following magnetic cloud, illustrating the importance of a magnetised CME model.
Constraining hydrostatic mass bias and cosmological parameters with the gas mass fraction in galaxy clusters
Authors: Wicker Raphaël , Douspis Marian , Salvati Laura , Aghanim Nabila 
Published: January 2022

The gas mass fraction in galaxy clusters is a convenient tool to use in the context of cosmological studies. Indeed this quantity allows to constrain the universal baryon fraction Ωb/Ωm, as well as other parameters like the matter density Ωm, the Hubble parameter h or the Equation of State of Dark Energy w. This gas mass fraction is also sensitive to baryonic effects that need to be taken into account, and that translate into nuisance parameters. Two of them are the depletion factor ϒ, and the hydrostatic mass bias B = (1 - b). The first one describes how baryons are depleted in clusters with respect to the universal baryon fraction, while the other encodes the bias coming from the fact that the mass is deduced from X-ray observations under the hypothesis of hydrostatic equilibrium.
We will show preliminary results, obtained using the Planck-ESZ clusters observed by XMM-Newton, on both cosmological and cluster parameters. We will notably discuss the investigation on a possible redshift dependence of the mass bias, which is considered to be non-existent in hydrodynamic simulations based on Λ-CDM, and compare our results with other studies.
Diurnal Salivary Cortisol Profiles in Patients with Cushing’s Syndrome
Authors: Braun Leah T. , Vogel Frederick , Zopp Stephanie , Rubinstein German , Schilbach Katharina , Künzel Heike , Beuschlein Felix , Reincke Martin 
Published: January 2022

Abstract
Background Quantification of salivary cortisol is one of the highly sensitive and specific screening parameters for Cushing’s syndrome (CS). However, only late-night salivary cortisol is part of the standard screening procedure. In this study, we aimed to analyze salivary cortisol day profiles in patients with different types of CS to test whether specific patterns might be relevant for diagnosis and subtyping.
Material and Methods Among 428 patients including those with confirmed Cushing’s syndrome (N=111, of those 75 with Cushing’s disease, 27 patients with adrenal CS and nine patients with ectopic CS), autonomous cortisol secretion (N=39) or exclusion of CS (control group, N=278) salivary cortisol was measured five times a day.
Results At each of the five time points, salivary cortisol was significantly higher in patients with CS compared to the control group (p≤0.001). Using the entire profile instead of one single salivary cortisol at 11 p.m. improved diagnostic accuracy (85 vs. 91%) slightly. Patients with ACTH-dependent CS had higher salivary cortisol levels than patients with adrenal CS. Also, morning cortisol was significantly higher in patients with ectopic CS than in patients with Cushing’s disease (p=0.04). Nevertheless, there was a strong overlap between diurnal profiles, and the diagnostic yield for subtyping was low.
Discussion The study results show that using diurnal salivary cortisol profiles for CS diagnosis results in a limited increase in diagnostic accuracy. With significant differences between Cushing subtypes, cortisol profiles are not useful in everyday clinical practice for subtyping of CS.
Public Awareness on Cancer-Associated Thrombosis among the Greek Population: First Findings from the ROADMAP-CAT Awareness Study
Authors: Souliotis Kyriakos , Golna Christina , Nikolaidi Sofia , Dreden Patrick V. , Vatheia Georgia , Gerotziafas Grigoris T. 
Published: January 2022

Abstract
Background Cancer-associated thrombosis (CAT) is the second cause of mortality after cancer itself. CAT is underestimated as a health challenge among oncologists, whereas the levels of awareness among patients and the public have not been systematically assessed and followed in the European Union countries.
Aim The Prospective Risk Assessment and Management of Patient with CAT (ROADMAP-CAT) Awareness study is an investigator-initiated, descriptive and nonexperimental study with a cross-sectional design and it explores CAT risk awareness among cancer patients and the general public in Greece to provide an impetus for health policy interventions and a benchmark against which impact of any future interventions may be assessed.
Methods A total of 1,003 participants aged above 18 years were contacted by phone after random selection from the national telephone catalogue. Participation was voluntary and completely anonymous, and a structured questionnaire was used to elicit responses. Data were analyzed using IBM SPSS version 25.
Results Among respondents, almost one-third (32.3%) reported CAT awareness, while only one in five (21.7%) were aware of the signs and symptoms of venous thromboembolism (VTE). Among patients with a personal history of cancer or of VTE, 47 and 58%, respectively, were aware of CAT risk. Of those aware of the association, 35.2% identified their treating physician as the main source of information. The level of awareness did not significantly differ by responders' demographics.
Conclusion The ROADMAP-CAT Awareness study revealed very low levels of awareness on CAT and VTE risk both among the general public and cancer patients in Greece. Awareness of the signs and symptoms of VTE was also particularly low. Treating physicians are not actively engaging in educating their patients about CAT. Public awareness of the increased risk of VTE among cancer patients is critical to prevent and diagnose the disease early. It is imperative that a structured campaign supports medical professionals to take the time to increase awareness and educate their patients on this matter if to improve morbidity and mortality of cancer patients.
On the Structure of Thailandene A: Synthetic Examination of the Cryptic Natural Product Aided by a Theoretical Approach
Authors: Aursnes Marius , Primdahl Karoline G. , Kaupang Åsmund , Park Jong-Duk , Seyedsayamdost Mohammad R. , Nolsøe Jens M. J. 
Published: January 2022

AbstractPhenotype-guided transposon mutagenesis has emerged as a valuable tool to access cryptic metabolites encoded in bacterial genomes. Recently, the method was demonstrated by inducing silent biosynthetic gene clusters in Burkholderia thailandensis. Amongst the isolated metabolic products, thailandene A exhibited promising antibiotic activity. By assignment, the linear polyenic aldehyde contained a labile motif, where an ostensible chiral secondary alcohol was interlaced in an allylic and a homoallylic constellation. Our attention was drawn to the pseudo-symmetric relationship between the heterofunctionalities, indicating the transformation of a dodecapentaenedial scaffold. Centering on an iterative cross-coupling protocol, the assigned all-E-(12R)-hydroxydodecapentaenal moiety was assembled by combining Zincke chemistry with the MIDA-attenuated Suzuki reaction developed in the Burke laboratory. Thus, according to the devised strategy, the mixed 1,2-bisborylated vinyl linchpin was consecutively functionalized with 5-bromodienal derivatives in a doubly orthogonal fashion. However, when the synthetic material was matched against the bacterial isolate, inconsistencies were observed. A re-examination of the cryptic natural product was conducted by juxtaposing analytical data from experiment and density functional theory calculations, in which hydroperoxide was evaluated as a candidate metabolite present in the bacterial isolate.
Surgery versus Medical Therapy in Luminal Ileocecal Crohn's Disease
Authors: Carvello Michele , Danese Silvio , Spinelli Antonino 
Published: January 2022

AbstractThe deeper understanding of the inflammatory process which gradually evolves into irreversible fibrosis and tissue damage has provided a precise picture of the disease course of luminal ileocecal Crohn's disease. According to the model of progressive structural damage, ideal time windows for medical and surgical treatment have been identified. While complicated disease clearly profits from surgical treatment, uncomplicated disease has become, in the last years, the most debatable setting in terms of different approaches including early surgery. On one hand, the rationale of traditional escalating medical therapy (step-up approach) has been undermined by the top-down medical approach. Indeed, the step-up approach has the possible drawback of delaying, up to a later disease stage, the use of more effective agents such as anti-tumor necrosis factors. Conversely, the top-down approach might expose patients to an overtreatment along with side effects including hypersensitivity to biologic agents. More recently, it has been shown how early surgery could be a valid option in this subset of patients being more cost-effective than medical therapy. Involving the surgeon at an early stage is considered now a good clinical practice and, in this scenario full of possibilities, the surgeon should be included into the decision-making process from the very beginning of patient management.
Therapeutic Endoscopy in Postoperative Pouch Complications
Authors: Chandan Saurabh , Shen Bo , Kochhar Gursimran S. 
Published: January 2022

AbstractIleal pouch-anal anastomosis (IPAA) or “J”-pouch as it is commonly referred to, is the treatment of choice in patients with medically refractory ulcerative colitis. IPAA can have infectious, inflammatory, and mechanical complications. Currently, there are no Food and Drug Administration-approved medical therapies for these complications. Surgery that may be eventually required can have significant morbidities due to the complexity of IPAA. Endoscopy is fast emerging as a leading modality of treatment for some of these pouch complications. Endoscopy in adjunct with medical treatment can help manage the majority of pouch-related disorders and improve the outcome.
Staging Pouch Surgery in Ulcerative Colitis in the Biological Era
Authors: Risto Anton , Abdalla Maie , Myrelid Pär 
Published: January 2022

AbstractRestorative proctocolectomy, or ileal pouch anal anastomosis, is considered the standard treatment for intractable ulcerative colitis. When the pelvic pouch was first introduced in 1978, a two-stage procedure with proctocolectomy, construction of the pelvic pouch, and a diverting loop with subsequent closure were suggested. Over the decades that the pelvic pouch has been around, some principal technical issues have been addressed to improve the method. In more recent days the laparoscopic approach has been additionally introduced. During the same time-period the medical arsenal has developed far more with the increasing use of immune modulators and the introduction of biologicals. Staging of restorative proctocolectomy with a pelvic pouch refers to how many sessions, or stages, the procedure should be divided into. The main goal with restorative proctocolectomy is a safe operation with optimal short- and long-term function. In this paper we aim to review the present knowledge and views on staging of the pouch procedure in ulcerative colitis, especially with consideration to the treatment with biologicals.
Pharmacomechanical Thrombectomy for Acute Limb Threatening Lower Extremity Arterial Thrombosis Secondary to COVID-19
Authors: Mundhada Rajesh Girdhardas , Rewatkar Atul Dharmaraj , Mundhada Anju Rajesh , Rewatkar Aishwarya Atul , Chandak Nikita Navin 
Published: January 2022

Abstract
Purpose The aim of this study was to report the clinical effectiveness and safety of pharmacomechanical thrombectomy (PMT) for acute limb threatening lower extremity arterial thrombosis secondary to coronavirus disease 2019 (COVID-19).
Methods In this retrospective study, the clinical and imaging records of six patients (6 men, mean age 56 years) with COVID-19-related lower extremity arterial thrombosis and treated with PMT using the Angio-Jet device were reviewed. Patients presented with symptoms of acute pain in the affected limb, pallor, pulselessness, paresthesia, or paralysis. Thrombosis involved below knee arteries in all patients, and above knee arteries in three patients. Reteplase 18 mg was infused into the thrombus using the power pulse mode on the Angio-Jet device. This was followed by rheolytic thrombectomy and then, intra-arterial infusion of urokinase 100,000 IU/hour for 5 hours. All patients received systemic intravenous heparin. Technical success, clinical success, and complications of PMT were analyzed.
Results The mean thrombectomy duration was 190.83 ± 99.18 seconds. Adjuvant balloon angioplasty was performed in two patients. The mean hospital stay was 7.67 ± 4.50 days. PMT was technically successful in all (100%) patients. Five patients had excellent clinical outcome with at least one palpable pulse and no tissue loss. One patient required minor amputation. One patient developed self-limiting retroperitoneal hematoma.
Conclusion In our series, PMT with supplemental intra-arterial urokinase infusion was highly successful in treating acute peripheral arterial thrombosis secondary to COVID-19.
Does Age Matter? Pulmonary Endarterectomy in the Elderly Patient with CTEPH
Authors: Wiedenroth Christoph B. , Bandorski Dirk , Ariobi Kanischka , Ghofrani H.-Ardeschir , Lankeit Mareike , Liebetrau Christoph , Pruefer Diethard , Mayer Eckhard , Kriechbaum Steffen D. , Guth Stefan 
Published: January 2022

AbstractBackground The gold standard treatment of patients with chronic thromboembolic pulmonary hypertension (CTEPH) is pulmonary endarterectomy (PEA). Little is known about the influence of advanced age on surgical outcome. Therefore, the aim of this study was to investigate the impact of patient's age on postoperative morbidity, mortality, and quality of life in a German referral center.Methods Prospectively collected data from 386 consecutive patients undergoing PEA between 01/2014 and 12/2016 were analyzed. Patients were divided into three groups according to their age: group 1: ≤ 50 years, group 2: > 50 ≤ 70 years, group 3: > 70 years.Results After PEA, distinct improvements in pulmonary hemodynamics, physical capacity (World Health Organization [WHO] functional class and 6-minute walking distance) and quality of life were found in all groups. There were more complications in elderly patients with longer time of invasive ventilation, intensive care, and in-hospital stay. However, the in-hospital mortality was comparable (0% in group 1, 2.6% in group 2, and 2.1% in group 3 [p = 0.326]). Furthermore, the all-cause mortality at 1 year was 1.1% in group 1, 3.2% in group 2, and 6.3% in group 3 (p = 0.122).Conclusions PEA is an effective treatment for CTEPH patients of all ages accompanied by low perioperative and 1-year mortality. CTEPH patients in advanced age carefully selected by thorough preoperative evaluation should be offered PEA in expert centers to improve quality of life, symptoms, and pulmonary hemodynamics.
Comparison of LRINEC Scoring System with Finger Test and Histopathological Examination for Necrotizing Fasciitis
Authors: Kazi Farah Naaz , Sharma J.V. , Ghosh Shaurav , Prashanth D. , Raja V. Om Pramod Kumar 
Published: January 2022

Abstract
Background Necrotizing fasciitis (NF) is a life-threatening condition requiring urgent attention. It is clinically difficult to diagnose, linked to severe systemic toxicity, and has poor prognosis. In 2001, Andreasen and coworkers described the “Finger test” for the diagnosis of NF. Subsequent studies have suggested early recognition and management of NF. In this study, we compare the LRINEC—Laboratory Risk Indicator for Necrotizing Fasciitis—scoring system with the “Finger test” and histopathological examination for diagnosis of NF.
Results In our study, LRINEC scoring system and Finger test are statistically significant in the diagnosis of NF. Males are more frequently affected, and the most common organism causing NF is Staphylococcus. Histopathology remained the gold standard for diagnosis of NF, while LRINEC score and Finger test were good diagnostic tools for early diagnosis, with sensitivities of 83.33 and 86.11%, respectively.
Conclusion LRINEC laboratory-based scoring system is easy and reliable diagnostic tool though histopathology remains the gold standard. There is statistically significant correlation between histopathology and laboratory criteria. LRINEC test is independently better than bedside Finger test alone or combined LRINEC and bedside Finger test.
How to Detect Isolated PEX10-Related Cerebellar Ataxia?
Authors: Nava Esmeralda , Hartmann Britta , Boxheimer Larissa , Capone Mori Andrea , Nuoffer Jean-Marc , Sargsyan Yelena , Thoms Sven , Rosewich Hendrik , Boltshauser Eugen 
Published: January 2022

AbstractA 4-year-old boy presented with subacute onset of cerebellar ataxia. Neuroimaging revealed cerebellar atrophy. Metabolic screening tests aiming to detect potentially treatable ataxias showed an increased value (fourfold upper limit of normal) for phytanic acid and elevated very-long-chain fatty acid (VLCFA) ratios (C24:0/C22:0 and C26:0/C22:0), while absolute concentrations of VLCFA were normal. Genetic analysis identified biallelic variants in PEX10. Immunohistochemistry confirmed pathogenicity in the patients' cultured fibroblasts demonstrating peroxisomal mosaicism with a general catalase import deficiency as well as conspicuous peroxisome morphology as an expression of impaired peroxisomal function. We describe for the first time an elongated peroxisome morphology in a patient with PEX10-related cerebellar ataxia.A literature search yielded 14 similar patients from nine families with PEX10-related cerebellar ataxia, most of them presenting their first symptoms between 3 and 8 years of age. In 11/14 patients, the first and main symptom was cerebellar ataxia; in three patients, it was sensorineural hearing impairment. Finally, all 14 patients developed ataxia. Polyneuropathy (9/14) and cognitive impairment (9/14) were common associated findings. In 12/13 patients brain MRI showed cerebellar atrophy. Phytanic acid was elevated in 8/12 patients, while absolute concentrations of VLCFA levels were in normal limits in several patients. VLCFA ratios (C24:0/C22:0 and/or C26:0/C22:0), though, were elevated in 11/11 cases. We suggest including measurement of phytanic acid and VLCFA ratios in metabolic screening tests in unexplained autosomal recessive ataxias with cerebellar atrophy, especially when there is an early onset and symptoms are mild.
Outcome Analysis of Severe Hyperbilirubinemia in Neonates Undergoing Exchange Transfusion
Authors: Zhang Ruili , Kang Wenqing , Zhang Xiaoli , Shi Lina , Li Rui , Zhao Yanmei , Zhang Jing , Yuan Xiao , Liu Shasha , Li Wenhua , Xu Falin , Cheng Xiuyong , Zhu Changlian 
Published: January 2022

Abstract
Objective Severe neonatal hyperbilirubinemia can cause neurological disability or mortality if not effectively managed. Exchange transfusion (ET) is an efficient treatment to prevent bilirubin neurotoxicity. The purpose of this study was to evaluate outcomes in severe neonatal hyperbilirubinemia with ET and to identify the potential risk factors for poor outcomes.
Methods Newborns of ≥28 weeks of gestational age with severe hyperbilirubinemia who underwent ET from January 2015 to August 2019 were included. Demographic data were recorded and analyzed according to follow-up outcomes at 12 months of corrected age. Poor outcomes were defined as death due to bilirubin encephalopathy or survival with at least one of the following complications: cerebral palsy, psychomotor retardation (psychomotor developmental index < 70), mental retardation (mental developmental index < 70), or hearing impairment.
Results A total of 524 infants were eligible for recruitment to the study, and 62 infants were lost to follow-up. The outcome data from 462 infants were used for grouping analysis, of which 398 cases (86.1%) had normal outcomes and 64 cases (13.9%) suffered poor outcomes. Bivariate logistic regression analysis showed that peak total serum bilirubin (TSB) (odds ratio [OR] = 1.011, 95% confidence interval [CI] = 1.008–1.015, p = 0.000) and sepsis (OR = 4.352, 95% CI = 2.013–9.409, p < 0.001) were associated with poor outcomes of hyperbilirubinemia. Receiver operator characteristic curve analysis showed that peak TSB ≥452.9 µmol/L could predict poor outcomes of severe hyperbilirubinemia.
Conclusion Peak TSB and sepsis were associated with poor outcomes in infants with severe hyperbilirubinemia, and peak TSB ≥452.9 µmol/L could predict poor outcomes.