bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficacy of an Adjuvant Lactobacillus Rhamnosus Formula in Improving Skin Lesions as Assessed by Pasi in Patients With Plaque Psoriasis From a University-affiliated, Tertiary-referral Hospital in São Paulo (Brazil): a Parallel, Double-blind, Randomized Clinical Trial
Authors: Suriano Enrico Stefano , Souza Marília Diogo Moço , Kobata Clarice Marie , Santos Felipe Henrique Yazawa , Mimiça Marcelo Jenné 
Published: October 2022

Abstract
Background: psoriasis is an inflammatory disease of the skin, characterized by erythematous plaques. It is rather common, affecting 2–4% of the population in western countries. Psoriasis’ etiology encompasses both genetic and environmental factors. Evidence suggests that the latter reflect the importance of changes in the microbiome for developing the disease. Thus, it is hypothesized that gut microbiome manipulation may arise as a way of treating psoriasis. However, few trials assessed the use of probiotics in psoriasis, although promising results were detected in small studies.
Objectives: to assess the efficacy of adjuvant probiotics (Lactobacillus rhamnosus) in treating plaque psoriasis patients.
Design, Setting and Participants: this was a randomized, parallel, placebo-controlled, double-blind trial with two arms: experimental (n=50) and control (n=53). Inclusion of subjects and data gathering lasted from November 2020 to August 2021. Subjects were consecutive plaque psoriasis patients under regular follow-up in the Dermatology unit of a university-affiliated, tertiary-referral hospital in São Paulo (Brazil). Eligibility criteria included being over 18 years old, having plaque psoriasis and not having other skin diseases, neoplasms nor systemic inflammatory diseases.
Interventions: subjects received standard-of-care plus probiotics (Lactobacillus rhamnosus formula). Controls received standard-of-care plus placebo.
Main Outcome Measure: primary outcome was skin lesion improvement as assessed by Psoriasis Area of Severity Index (PASI) at six months. Secondary outcome was quality-of-life as assessed by Dermatology Life Quality Index (DLQI) at six months.
Results: regarding within-group analyses, changes in both PASI and DLQI were non-significant for the experimental group (mean PASI decreased by 1.58, p=0.105, and mean DLQI increased by 0.05, p=0.873) and significant for controls (mean PASI decreased by 1.90, p=0.019, and mean DLQI decreased by 3.33, p=0.031). Between-group analyses returned non-significant results (p=0.620).
Conclusions: our findings do not support the hypothesis that gut microbiome modulation via ingestion of Lactobacillus rhamnosusproduces clinical improvement in psoriasis patients. Further research is encouraged.
Trial Registration: retrospectively registered at the Brazilian Clinical Trials Registry (RBR-8js7t83) on 08/02/2022.
Effect of duodenal-jejunal bypass on diabetes in the early postoperative period
Authors: Okikawa Shohei , Kashihara Hideya , Shimada Mitsuo , Yoshikawa Kozo , Tokunaga Takuya , Nishi Masaaki , Takasu Chie , Wada Yuma , Yoshimoto Toshiaki 
Published: October 2022

Abstract
Metabolic surgery is an effective treatment for patients with type 2 diabetes mellitus (T2DM). The aim of this study was to investigate the effect of duodenal-jejunal bypass (DJB) in a rat model of T2DM during the early postoperative period. A rat model of non-obese T2DM was allocated to two groups: a sham group and a DJB group. On postoperative day 1 (1POD), oral glucose tolerance testing (OGTT) was performed and the changes of glucose transporter expressions in the small intestine was evaluated. [18F]-fluorodeoxyglucose ([18]-FDG) uptake was measured in sham- and DJB-operated rats using positron emission tomography-computed tomography (PET-CT). DJB improved the glucose tolerance of the rats on 1POD. The expression of sodium-glucose cotransporter 1 (SGLT1) and glucose transporter 1 (GLUT1) was high, and that of GLUT2 was low in the alimentary limb (AL) of rats in the DJB group. PET-CT showed that [18F]-FDG uptake was high in the proximal jejunum of DJB-operated rats. These results suggest that DJB improve glucose tolerance in very early postoperative period as the result of glucose accumulation in the AL because of changes in glucose transporter expression.
Pedestrian Flow Identification and PredictingOccupancy of Indoor Areas
Authors: Tsiamitros Nikolaos , Mahapatra Tanmaya , Passalidis Ioannis , K Kailashnath , Pipelidis Georgios 
Published: October 2022

Abstract
Indoor localisation is used for locating the objects and people within the buildings where our outdoor tracking tools and technologies cannot provide precise results due to the unavailability of any visual contact with the satellites used by them. With the advancement of Internet of Things (IoT) devices, indoor localisation in indoor buildings like airports, hotels, and tourist places is possible. This paper aims to improve the analytics research, focusing on data collected through indoor localisation methods. Our smart devices constantly try to improve the user experience by recurrently broadcasting automatic connectivity requests. These packets are known as Wi-Fi probe requests and can encapsulate various spatio-temporal information of the device carrier. The objective of this paper is to perform a detailed comparison between the Prophet model developed by Facebook and our implementation of the Auto Regressive Moving Average (ARMA) model. Prophet Model is an additive model that requires no manual effort and can easily detect and handle outliers or missing data.In contrast, the ARMA model may require more effort and deep statistical analysis but allows the user to tune it and reach a more personalised result. Second, we have attempted to understand human behaviour. We have used historical data to forecast using two different models, which we conclude by comparing. Subsequently, we mapped each probe request to the section of our place of interest where it was captured while also considering its uncertainty radius. Finally, we have performed pedestrian flow analysis by identifying the most common paths followed inside our place of interest.
Effects of cocktail combinations of antisense oligonucleotides on potency
Authors: Yanagidaira Mitsugu , Yoshioka Kotaro , Nagata Tetsuya , Nakao Shoichi , Miyata Kenichi , Yokota Takanori 
Published: October 2022

Abstract
Background: The co-administration of several therapeutic oligonucleotides targeting the same transcript is a beneficial approach. It broadens the target sites for diseases associated with various mutations or splice variants. However, little is known how a combination of antisense oligonucleotides (ASOs), which is one of the major modalities of therapeutic oligonucleotides, affects the potency. In this study, we aimed to elucidate the cocktail-effects of ASOs and the relationship between the target sites and potency of different combinations.
Method and Results: We designed 113 ASOs targeting human superoxide dismutase 1 pre-mRNA and found 13 ASOs that had comparable silencing activity in vitro. An analysis of cocktail-effects on the silencing potency of 38 pairs of two ASOs on HeLa cells revealed that 30 pairs had comparable potency to that of two ASOs; on the other hand, eight pairs had reduced potency, indicating a negative impact on the activity. A reduced potency was seen in pairs targeting the same intron, exon-intron combination, or two different introns. The sequence distance of target sites was not the major determinant factor of cocktail-effects. In addition, a cocktail of three ASOs preserving the potency could be designed by avoiding two-ASO pairs, which had a reduced potency.
Conclusions: This study revealed that more than half of the combinations retain their potency by paring two ASOs; in contrast, some pairs had a reduced potency. This could not be predicted only by the distance between the target sites.
PEDF peptide stimulates chondrocyte regeneration in rats with monoiodoacetate-induced articular cartilage injury
Authors: Lu Yung-Chang , Ho Tsung-Chuan , Huang Chang-Hung , Yeh Shu-I , Chen Show-Li , Tsao Yeou-Ping 
Published: October 2022

Abstract
Background: Intra-articular injection of monoiodoacetate (MIA) has shown to induce extensive chondrocyte degeneration/death in articular cartilage (AC), resulting in destruction of the AC in animals. This has been used often as model of osteoarthritis (OA). Pigment epithelium-derived factor (PEDF) and its derived short peptide 29-mer have been shown to heal tissue injury by activating various types of stem/progenitor cells localized near the lesions. Here we investigated whether the 29-mer is able to evoke chondrogenesis in rats with MIA-injured AC.
Methods: AC destruction was induced in Sprague-Dawley rats by a single intra-articular injection of MIA (1 mg) in the right knee. After MIA injection for 7 days, the 29-mer infused with 5% hyaluronic acid (HA) was injected intra-articularly twice, at 4-day intervals. Also, BrdU was injected intraperitoneally into the rats to detect cell proliferation in the damaged AC. The histopathology of AC was determined by hematoxylin and eosin (H&E) staining and Safranin O staining. The regeneration of chondrocytes in the AC was detected by dual-immunostaining of BrdU and chondrocyte markers, including aggrecan, collagen type 2 and Sox9. Changes in hind paw weight distribution were measured to evaluate the MIA-induced joint discomfort. Bone marrow-derived mesenchymal stem cells (MSCs) were used to detect chondrogenic differentiation. The involvement of the PEDF receptor and STAT3 signaling on the 29-mer effects was evaluated using specific inhibitors.
Results: MIA injection caused chondrocyte death throughout the AC, with cartilage degeneration thereafter. The 29-mer/HA treatment induced extensive chondrocyte regeneration in the damaged AC, accompanied by the partial recovery of the cartilaginous matrix. The 29-mer/HA also exerted an antinociceptive effect in rats. In culture, the 29-mer promoted chondrogenic differentiation of MSCs with evidence of increased expression of chondrogenic marker genes and proteoglycans, as well as the phosphorylation of STAT3. Pharmacological inhibitors of PEDF-R and STAT3 signaling dramatically blocked the 29-mer effects on cultured MSCs and chondrogenesis in the injured AC.
Conclusions: The 29-mer/HA formulation has the ability to stimulate chondrocyte regeneration in the MIA damaged AC. The 29-mer may be a novel agent for the development of future OA treatments.
SARWAS Recommendation Framework Using Deep Learning
Authors: Choudhary Chaitali , Singh Inder , Biju Soly Mathew , Kumar Manoj 
Published: October 2022

Abstract
Sentiment-based recommendation systems are growing very fast nowadays , as users cannot express their opinion on the Likert scale from 1 to 5. Most of the current techniques work on either one of the parameters (ratings or reviews), mainly on reviews. This paper explored a new algorithm, SARWAS, involving both ratings and reviews for the recommendation system. This paper proposed a deep learning model using a sentiment and rating weighted association score (SARWAS) framework for combining ratings and reviews. We scraped reviews from e-commerce sites and calculated polarity and subjectivity for each review. Then a neural network model is further applied to calculate the weights and determine a combined score for a product. We evaluated the proposed model in terms of correlation between rating, review, and recommendation. It is being observed from the experiment that the proposed method produced satisfactory results in terms of accuracy. The correlation of reviews and recommendations is estimated to be more than ratings and recommendations with improved accuracy and precision of 95 percent and 89 percent.
Application of KNN-based Isometric Mapping and Fuzzy C-Means Algorithm to Predict Short-term Rockburst Risk in Deep Underground Projects
Authors: Kamran Muhammad , Ullah Barkat , Ahmad Mahmood , Sabri Mohanad Muayad Sabri 
Published: October 2022

Abstract
The rockburst phenomenon is the major source of the high number of casualties and fatalities during the construction of deep underground projects. Rockburst poses a severe hazard to the safety of employees and equipment in subsurface mining operations. It is a hot topic in recent years to examine and overcome rockburst risks for the safe installation of deep urban engineering designs. Therefore, for a cost-effective and safe underground environment, it is crucial to determine and predict rockburst intensity prior to its occurrence. A novel model is presented in this study that combines unsupervised and supervised machine learning approaches in order to predict rockburst risk. The database for this study was built using authentic microseismic monitoring occurrences from the Jinping-II hydropower project in China, which consists of 93 short-term rockburst occurrences with six influential features. The prediction process was succeeded in three steps. Firstly, the original rockburst database's magnification was reduced using a state-of-the-art method called isometric mapping (ISOMAP) algorithm. Secondly, the dataset acquired from ISOMAP was categorized using the fuzzy c-means algorithm (FCM) to reduce the minor spectral heterogeneity impact in homogenous areas. Thirdly, K-Nearest neighbour (KNN) was employed to anticipate different levels of short-term rockburst datasets. The KNN's classification performance was examined using several performance metrics. The proposed model correctly classified about 96% of the rockbursts events in the testing datasets. Hence, the suggested model is a realistic and effective tool for evaluating rockburst intensity. Therefore, the proposed model can be employed to forecast the rockburst risk in the early stages of underground projects that will help to minimize casualties from rockburst.
Seropositivity for toxocariasis is associated with worse cognitive functioning in older adults: The national health and nutrition examination survey 2011 to 2014
Authors: Li Chunmei 
Published: October 2022

Abstract
Background
Toxocariasis is an important broad-spectrum zoonotic parasite linked with poorer cognitive functioning in animals. However, this relationship is rarely studied in humans.
Method
A total of 3,188 older adults aged 60 and above from the National Health and Nutrition Examination Survey 2011 to 2014 were included. IgG antibody against Toxocara sapp. was tested by a Luminex assay using recombinant rTc-CTL-1 antigen. A value > 23.1 mean fluorescence intensity (MFI) indicated positive for toxocariasis, ≤ 23.1 MFI as negative. The Consortium to Establish a Registry for Alzheimer’s Disease Word Learning subtest (CERAD-WL) immediate and delayed memory, the Animal Fluency test (AFT), and the Digit Symbol Substitution Test (DSST) were used to assess cognitive functioning. Cognitive test-specific and global cognitive z scores were computed using means and standard deviations. Multivariate linear regression models were constructed to examine the association between toxocariasis and each cognitive test-specific and global cognitive standardized z score. All models were controlled for age, race/ethnicity, education, depressive symptoms, smoking status, body mass index (BMI), prevalent coronary heart disease, stroke, and systolic blood pressure.
Results
Most of the 3188 participants (mean age 70.0) were female (51.3%), non-Hispanic White (47.1%), and completed some college or above (48.1%). A total of 288 participants were seropositive for toxocariasis (9.0%). Adjusted linear regression showed that compared with participants with negative toxocariasis, those with positive toxocariasis had a lower CERAD W-L immediate recall (beta [β] -0.19, 95% Confidence interval [CI] -0.32, -0.06), AFT (β -0.16, 95% CI -0.29, -0.03), DSST (β -0.22, 95% CI -0.36, -0.09) as well as global cognition (β -0.20, 95% CI -0.33, -0.06) standardized z scores after controlling for covariates.
Discussions
In our study, seropositive toxocariasis was significantly associated with test-specific and global cognition in older adults. Public health measures to prevent human toxocariasis might help protect older adults’ cognitive function.
A rare sekaninaite occurrence in the Nenana Coal Basin, Alaska Range, Alaska
Authors: Reidel Stephen P. , Ross Martin E. 
Published: October 2022

AbstractCoal-seam fires are not uncommon and occur in coal deposits of all ages. Coal-seam fires have been noted in Alaska, but this paper is the first to describe the mineralogy and petrology of a coal-seam fire in the Mystic Creek coal basin in the remote eastern part of the Nenana Coal Basin, Alaska Range. The coal is Miocene and part of the Healy Creek Formation of the Usibelli Group. The coal-fire products were studied optically and analyzed using XRF, XRD, and electron microprobe. The host rock is a silty sandstone consisting mainly of quartz, feldspar, and minor hematite and clay. The coal-seam fire fused and melted the country rock producing a metasediment-clinker and paralava. Sekaninaite (Fecordierite), plagioclase, and fayalite are the main minerals that formed along with titanomagnetite, mullite, augite, and an unidentified Al-Fe-Ti oxide mineral. Petrographic analysis shows there are at least three distinct lithologies in the paralava at thin section scale: a vesicular, holocrystalline sekaninaiteplagioclase ± olivine bearing area; holocrystalline areas dominated by plagioclase and quartz ± minor sekaninaite; glassy bodies; and a bulbous, lenticular body of coarse-grained sekaninaite and lesser olivine. The paralava is an andesite with rhyolitic residual glass. Oxidation and fusion of the sediment was the first phase of pyrometamorphism, where the sediment becomes brown-red and sekaninaite begins to form. The metasediment melts forming vesicles in a black glass; sekaninaite formation is well underway. The melt separates from the host and coalesces to form the paralava. As the paralava cools, fayalite and sekaninaite precipitate, accompanied by plagioclase, quartz, titanomagnetite, and an Al-Fe-Ti oxide. Proximity to the surface allowed quenching of the remaining liquid to rhyolitic glass. Numerical modeling was employed to calculate the liquidus temperature (1140 to 1200 °C) and understand the crystallization pathway to the rhyolitic glass. In all models, sekaninaite precipitation is the most important mineral leading to the rhyolitic glass.
Development and Validation of a 3-Dimensional Flexible Laryngoscopy Training Simulator
Authors: Gillespie Amanda I. , Shelly Sandeep , Tucker Sarah Jo , Hollister Scott J. , Tkaczuk Andrew , Klein Adam 
Published: October 2022

The objective of this study was to validate the use of a 3-Dimensional Flexible Laryngoscopy Training Simulator. This is a simulation device development and validation study. Anonymized CT scan data from a head/neck CT of a patient with normal anatomy was imported and a head/neck digital model was created. A 3D simulation model was printed using a stiff (Stratasys Vero) and flexible (Stratasys Agilus) material combination with a ShoreA hardness value of 60. Novices and experts were instructed and provided 5 trials to pass the laryngoscope. The videos of the first and the last trial were recorded and evaluated by three different evaluators. Performances were measured by the amount of time spent and precision of the task. Repeated measures of ANOVA and generalized linear model with binomial proportion was used were utilized to analyze the data. The post training scores were statistically significantly higher than pre training scores (Mean: 15.57 vs. 13.01, p <0.0001) controlling for trainee experience. The time taken to complete a successful pass post training was statistically significantly lesser than pre training (Mean: 62.55 secs vs. 36.36 secs, p-value = 0.0007) controlling for individual’s experience. The odds of becoming skilled at the task was 4 times higher post training in comparison to pre training, controlling for individual’s experience (OR: 4.05, p-value: 0.0026). The 3-Dimensional Flexible Laryngoscopy Training Simulator is a valid trainer for both novice and experienced individuals. The simulator can improve technical skill performance and is critical for medical training.
The Sequestration of Bile Acids, A Non-Absorbed Method for Cholesterol Reduction. A Review
Authors: Mandeville W. Harry , Goldberg Dennis I. 
Published: October 2022

Abstract:
Cholesterol lowcri11g therapies arc availahlc which act via several different mechanisms. The therapeutic classes currently available which afford these mechanisms arc diet, statins, fibrates, niacin, probucol and sequestrants. This review will focus on the various hilc acid scqucslranls, a class or lhcrapculics which has been under utilized due to patient compliance issues attributed lo the quantity or material required for effective treatment.
Regulation of Bile Acid Biosynthesis
Authors: Princen Hans M.G. , Post Sabine M. , Twisk Jaap 
Published: October 2022

Abstract:
An elevated concentration of low density lipoprotein (LDL) cholesterol is an independent risk factor for cardiovascular disease. The only quantitatively significant way by which cholesterol is removed from the body is via the bile, either directly or after conversion to bile acids. Therapeutic modalities which increase bile acid biosynthesis,
e.g. bile acid-binding resins, have been shown to reduce plasma LDL levels and the risk of coronary heart disease. Their effects, however, are limited and patients' acceptibility is poor. This warrants the search for more potent drugs and new ways to enhance bile acid synthesis. In this review the various pathways along which bile acids are formed will be discussed with emphasis on the regulation of cholesterol 7o:-hydroxylase, the major rate­ limiting step in bile acid formation, as a target to increase bile acid synthesis. In the past
5 years our understanding of the transcriptional mechanism that regulates the expression of this gene has rapidly expanded. In view of the increasing evidence for the substantial contribution of the alternative or 27- hydroxylase route to bile acid synthesis, the current knowledge on sterol 27-hydroxylase, the first enzyme in this pathway and a potentially new target, is reviewed. Several companies are involved in developing new bile acid sequestrants and other inhibitors of intestinal bile acid absorption to remove cholesterol from the body. This review article presents recent developments in this field as appeared in the patent literature during past the years.
Inhibitors of Influenza Virus Neuraminidase and Endonuclease
Authors: Sham Hing L. , Chen Xiaoqi 
Published: October 2022

Abstract:
Influenza virus infection is considered to be one of the most common, yet serious respiratory infections in terms of morbidity and mortality. Currently available medications are limited. Amantadine and Rimantidine are only partially successful in treating. influenza A infection, and have no effect against influenza B viruses. Vaccination shows some success but meets with the difficulties of predicting the highly variable mutated strains in the forthcoming epidemic season. Recently, there has been extensive research efforts focuse on the areas of inhibitors of influenza virus
•neuraminidase and endonuclease. With detail understanding of the structural biology of influenza virus neuraminidase, Glaxo-Welcome's GG167 became the first potent neurami­
nidase inhibito which showed chemotherapeutic and chemoprophylactic effects in early human clinical trials. GGS4071, from Gilead Pharmaceutical, also demonstrated equivalent in vitro and invivo activities asGG I 67. GS4104, the ester pro-drug of GS4071 has good oral bioavailabilities in the animal assays. Along with the rapid developments in the area of neuraminidase inhibitors, cap-dependent endonuclease inhibitors which target the transcription of influenza virus mRNA are of great interest. The cap-dependent endonuclease seems to be unique to influenza virus with no cellular counterpart. The recent progress in the development of inhibitors of influenza neuraminidase and endonuclease are discussed in this review.