bluuebunny/crossref_metadata_2025_split huggingface dataset:
Involving Others
Authors: Craske Michelle G. , Barlow David H. 
Published: May 2022

Abstract
This chapter examines the process of discussing and planning ways for clients to involve significant others in their treatment. Significant others frequently have a big impact on panic disorder and particularly agoraphobia. Indeed, these individuals can play both positive and negative roles in the development and maintenance of agoraphobia and also in its treatment. The behavior and attitudes of significant others also can have strong effects, both positive and negative, on the client’s anxiety and avoidance. For these and other reasons, involving significant others in treatment can be quite beneficial, a suggestion that has been supported by empirical research. The chapter then looks at several ways in which interpersonal relationships, particularly relationships with a spouse or partner, can be disrupted by panic and agoraphobia situations. It also considers the roles that significant others can take on in assisting with exposure practices.
Learning to Record Panic and Anxiety
Authors: Barlow David H. , Craske Michelle G. 
Published: May 2022

Abstract
This chapter discusses the importance and method of recordkeeping, looking at ways to objectively record panic, anxiety, and other moods. Learning to be an observer as opposed to a victim of one’s own anxiety is a first step toward gaining control. Through recordkeeping, one will learn to observe when, where, and under what circumstances one’s panic and anxiety occur. One will also learn to understand the way in which one experiences panic and anxiety, in terms of what one thinks, what one feels, and what one does. This understanding is important because this program is designed specifically to change anxious thinking, anxious feelings, and anxious behaviors. Finally, recording helps one to evaluate progress. The chapter then looks at the three forms of recording panic and anxiety: Your Panic Attack Record, Your Daily Mood Record, and Your Progress Record.
Learning Breathing Skills and Understanding Your Negative Thinking
Authors: Craske Michelle G. , Barlow David H. , Woodard Lauren S. 
Published: May 2022

Abstract
This chapter discusses the mistaken beliefs about panic as well as the importance of understanding one’s negative thoughts and learning breathing skills. Common myths and mistaken beliefs about the physical symptoms of fear include sensations of going insane, losing control, suffering a nervous collapse, suffering a heart attack, and fainting. Such mistaken beliefs can result in a vicious “fear of fear” cycle. The chapter then assesses where these mistaken beliefs come from. It also looks at the initial steps for challenging myths, mistaken beliefs, and negative thoughts. Finally, the chapter explains the mechanics of breathing and the symptoms of overbreathing/hyperventilation, before presenting a specific exercise to teach the skill of diaphragmatic breathing.
A list of 49 new stellar twins from the Kepler catalogue of eclipsing binary stars
Authors: Yücel Gökhan , Bakış Volkan 
Published: May 2022

ABSTRACT
49 new eclipsing twin binary candidates are identified and analysed based on the Kepler eclipsing binary light curves. Their colours and spectral types are calculated according to our classification. A comparison of the spectral type distribution of eclipsing twin binary systems showed that F-type twins dominate among others, which agrees well with recent studies. The distance of eclipsing twin binaries from the galactic plane shows that F- and G-type twins can be seen at any distance from the galactic plane and most of the known eclipsing binary twins are located within 200 pc of the galactic plane, which could be interpreted as these systems are the members of thin disc population. As a case study, a twin binary system selected from our updated list of twins, V396 Gem, has been analysed with spectroscopic and Kepler data. As a result, we have derived the physical parameters of the components of V396 Gem as M1,2(M⊙) = 1.814 ± 0.114, 1.797 ± 0.114; R1,2(R⊙) = 2.655 ± 0.078, 2.659 ± 0.090; $T_{\mathrm{eff}_{1,2}}(\mathrm{ K})=7000\pm 100$, 6978 ± 100; and [M/H] = 0.11 ± 0.03. We have calculated the evolutionary status of the components by using mesa. Accurately derived physical parameters of the components of V396 Gem have allowed us to determine the age of the system as 1.168 ± 0.149 Byr.
SVA Retrotransposons and a Low Copy Repeat in Humans and Great Apes: A Mobile Connection
Authors: Damert Annette 
Published: May 2022

Abstract
Segmental duplications (SDs) constitute a considerable fraction of primate genomes. They contribute to genetic variation and provide raw material for evolution. Groups of SDs are characterized by the presence of shared core duplicons. One of these core duplicons, low copy repeat (lcr)16a, has been shown to be particularly active in the propagation of interspersed SDs in primates. The underlying mechanisms are, however, only partially understood. Alu short interspersed elements (SINEs) are frequently found at breakpoints and have been implicated in the expansion of SDs.
Detailed analysis of lcr16a-containing SDs shows that the hominid-specific SVA (SINE-R-VNTR-Alu) retrotransposon is an integral component of the core duplicon in Asian and African great apes. In orang-utan, it provides breakpoints and contributes to both interchromosomal and intrachromosomal lcr16a mobility by inter-element recombination. Furthermore, the data suggest that in hominines (human, chimpanzee, gorilla) SVA recombination-mediated integration of a circular intermediate is the founding event of a lineage-specific lcr16a expansion. One of the hominine lcr16a copies displays large flanking direct repeats, a structural feature shared by other SDs in the human genome.
Taken together, the results obtained extend the range of SVAs’ contribution to genome evolution from RNA-mediated transduction to DNA-based recombination. In addition, they provide further support for a role of circular intermediates in SD mobilization.
Real-world safety and effectiveness of canakinumab in patients with tumour necrosis factor receptor-associated periodic syndrome or hyperimmunoglobulinaemia D syndrome: Interim results from post-marketing surveillance in Japan
Authors: Hosono Kumiko , Matsumoto Kazuko , Shimbo Miki , Tsumiyama Isao , Kato Chihiro 
Published: May 2022

ABSTRACTObjectivesTo assess the real-world safety and effectiveness of canakinumab in patients in Japan with tumour necrosis factor receptor-associated periodic syndrome (TRAPS) or mevalonate kinase deficiency/hyperimmunoglobulinaemia D with periodic fever syndrome (MKD/HIDS).MethodsAll patients with TRAPS or MKD/HIDS who received canakinumab following drug approval in Japan were registered in a post-marketing all-patient surveillance with a 2-year observation period. Herein, the interim results are reported.ResultsFifteen patients with TRAPS and seven with MKD/HIDS were included in the safety and effectiveness analysis set. Adverse drug reactions were reported in 26.67% (n = 4) and 42.86% (n = 3) of TRAPS and MKD/HIDS patients, respectively. Most common adverse drug reactions were upper respiratory tract inflammation (13.33%, n = 2) and pyrexia (42.86%, n = 3) in TRAPS and MKD/HIDS patients, respectively. No serious adverse drug reactions were observed in either TRAPS or MKD/HIDS patients. The proportion of responders was 46.67% and 14.29% in the TRAPS and MKD/HIDS groups, respectively; 72.73% and 66.67% achieved clinical remission, while 90.91% and 66.67% achieved serological remission by Week 4 in the TRAPS and MKD/HIDS groups, respectively.ConclusionsThese interim results provide the first evidence of the real-world effectiveness of canakinumab in patients with TRAPS or MKD/HIDS in Japan. No new safety concerns were identified.
A Randomized Pilot of a Tailored Smoking Cessation Quitline Intervention for Individuals Who Smoke and Vape
Authors: Vickerman Katrina A , Carpenter Kelly M , Miles Lyndsay N , Hsu Johnathan M , Watt Karen A , Brandon Thomas H , Hart Jonathan T , Javitz Harold S , Wagener Theodore L 
Published: May 2022

Abstract

Introduction
Although e-cigarettes are not a federally approved tobacco cessation aid in the United States, many smokers use them to quit or cut down on smoking. Tailored behavioral support could improve rates of complete smoking cessation for those individuals.

Aims and Methods
A novel behavioral treatment to help dual cigarette and e-cigarette users quit smoking was tested in a randomized pilot with a state tobacco quitline. Ninety-six dual users of cigarettes and e-cigarettes were recruited from incoming state quitline callers and randomized to receive enhanced e-cigarette coaching (EEC) or quitline treatment as usual (TAU) to examine EEC feasibility and acceptability. Outcomes at 3 months were treatment satisfaction, engagement, beliefs, and smoking cessation. This pilot was not powered to detect differences in quit rates.

Results
Sixty-nine percent responded to the 3-month survey. EEC treatment satisfaction was noninferior to TAU: 93.8% (30/32) of EEC and 73.5% (25/34) of TAU reported being “very satisfied” or “satisfied” with treatment, respectively. EEC participants completed more coaching calls than TAU (M = 3.4 vs. M = 2.7, p = .03), and the majority in both groups elected to receive nicotine replacement therapy (EEC: 100%, TAU: 94%, p = .24). With missing data imputed as smoking, intent-to-treat 7-day point prevalence smoking abstinence rates were 41.3% (19/46) for EEC and 28.0% (14/50) for TAU (p = .20).

Conclusions
The EEC quitline intervention for dual cigarette and e-cigarette users demonstrated high levels of treatment satisfaction and engagement. This pilot was not powered to detect significant differences in smoking cessation; however, cessation rates were promising and warrant evaluation in a fully powered trial.

Implications
If this scalable behavioral treatment to help dual cigarette and e-cigarette users quit smoking proves to be effective in a larger trial, quitlines could implement this harm reduction approach to improve outcomes for callers who already use e-cigarettes and are planning to use them while quitting smoking.
Domino effect of a natural cascade alpine lake system on the Third Pole
Authors: Wang Lei , Liu Hu , Zhong Xiaoyang , Zhou Jing , Zhu Liping , Yao Tandong , Xie Changwei , Ju Jianting , Chen Deliang , Yang Kun , Zhao Lin , Lu Shanlong , Khanal Sonu , Jin Jiming , Liu Wenhui , Liu Baokang , Du Yu'e , Yao Xiaojun , Lei Yanbin , Zhang Guoqing , Nepal Santosh 
Published: May 2022

Abstract
Third Pole natural cascade alpine lakes (NCALs) are exceptionally sensitive to climate change, yet the underlying cryosphere-hydrological processes and associated societal impacts are largely unknown. Here, with a state-of-the-art cryosphere-hydrology-lake-dam model, we quantified the notable high-mountain Hoh-Xil NCALs basin (including Lakes Zonag, Kusai, Hedin Noel, and Yanhu, from upstream to downstream) formed by the Lake Zonag outburst in September 2011. We demonstrate that long-term increased precipitation and accelerated ice and snow melting as well as short-term heavy precipitation and earthquake events were responsible for the Lake Zonag outburst; while the permafrost degradation only had a marginal impact on the lake inflows but was crucial to lakeshore stability. The quadrupling of the Lake Yanhu area since 2012 was due to the tripling of inflows (from 0.25 to 0.76 km3/year for 1999 to 2010 and 2012 to 2018, respectively). Prediction of the NCALs changes suggests a high risk of the downstream Qinghai–Tibet Railway, necessitating timely adaptions/mitigations.
Impaired Ability to Relax Pelvic Floor Muscles in Men With Chronic Prostatitis/Chronic Pelvic Pain Syndrome
Authors: Yani Moheb S , Eckel Sandrah P , Kirages Daniel J , Rodriguez Larissa V , Corcos Daniel M , Kutch Jason J 
Published: May 2022

Abstract

Objective
Excessive pelvic floor muscle activity has been suggested as a source of pain in chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS). Our objective was to determine whether men with CP/CPPS have changes in neural drive that impair their ability to relax pelvic floor muscles.

Methods
We recruited 90 men (42 with CP/CPPS and 48 in the control group [without a history of pelvic pain]). All completed the National Institutes of Health Chronic Prostatitis Symptom Index (NIH-CPSI). We quantified the ability to relax by comparing resting pelvic floor muscle activity under 2 conditions: a “rest-only” condition, in which participants were instructed to simply relax, and a “rest-between-contraction” condition, in which participants were instructed to rest for several seconds between voluntary pelvic floor muscle contractions. We used multivariate mixed-effects models to examine differences between the groups (men with CP/CPPS and men in the control group) as well as the effect of 6 symptoms captured by the NIH-CPSI: pain related to location (perineum, testicles, penis, suprapubic region) and activity (urination, ejaculation).

Results
Men with CP/CPPS were significantly different from men in the control group; men with CP/CPPS had higher resting activity in the rest-between-contraction condition than in the rest-only condition, whereas men in the control group had similar resting activities in both conditions. This effect was strongest in men who reported ejaculation-related pain, which was 70% of the CP/CPPS group.

Conclusion
Men without a history of pelvic pain were able to relax their pelvic floor muscles back to baseline after performing voluntary pelvic floor muscle contractions. In contrast, men with CP/CPPS, particularly those with ejaculation-related pain, had an impaired ability to relax their pelvic floor muscles.

Impact
This study may support the investigation of more personalized physical therapist approaches for CP/CPPS that enhance the ability to relax pelvic floor muscles as a mechanism for pain reduction.
Brain states in freely behaving marmosets
Authors: Bukhtiyarova Olga , Chauvette Sylvain , Seigneur Josée , Timofeev Igor 
Published: May 2022

Abstract

Study Objectives
We evaluated common marmosets as a perspective animal model to study human sleep and wake states.

Methods
Using wireless neurologger recordings, we performed longitudinal multichannel local field potential (LFP) cortical, hippocampal, neck muscle, and video recordings in three freely behaving marmosets. The brain states were formally identified using self-organizing maps.

Results
Marmosets were generally awake during the day with occasional 1–2 naps, and they slept during the night. Major electrographic patterns fall in five clearly distinguished categories: wakefulness, drowsiness, light and deep NREM sleep, and REM. Marmosets typically had 14–16 sleep cycles per night, with either gradually increasing or relatively low, but stable delta power within the cycle. Overall, the delta power decreased throughout the night sleep. Marmosets demonstrated prominent high amplitude somatosensory mu-rhythm (10–15 Hz), accompanied with neocortical ripples, and alternated with occipital alpha rhythm (10–15 Hz). NREM sleep was characterized with the presence of high amplitude slow waves, sleep spindles and ripples in neocortex, and sharp-wave-ripple complexes in CA1. Light and deep stages differed in levels of delta and sigma power and muscle tone. REM sleep was defined with low muscle tone and activated LFP with predominant beta-activity and rare spindle-like or mu-like events.

Conclusions
Multiple features of sleep–wake state distribution and electrographic patterns associated with behavioral states in marmosets closely match human states, although marmoset have shorter sleep cycles. This demonstrates that marmosets represent an excellent model to study origin of human electrographical rhythms and brain states.
Influence of Minimum Alveolar Concentration and Inhalation Duration of Sevoflurane on Facial Nerve Electromyography in Hemifacial Spasm: A Randomized Controlled Trial
Authors: Yang Li-Na , Chen Chan , Zhao Dong-Dong , Hu Miao , Li Jia-Cen , Yang Meng-Chang 
Published: May 2022

Background:
The lateral spread response (LSR) is an electromyography feature of hemifacial spasm; intraoperative reduction in the LSR is associated with positive surgical outcomes. This study examined the effects of different minimum alveolar concentrations (MACs) and durations of sevoflurane inhalation on the LSR.

Methods:
Eighty patients undergoing microvascular decompression surgery for hemifacial spasm were randomly allocated to receive propofol-remifentanil total intravenous anesthesia alone or in combination with sevoflurane at 0.5, 0.75, or 1 MAC. The LSR and orbicularis oculi muscle wave were recorded before and at 15 and 30 minutes after the start of sevoflurane administration.

Results:
Sevoflurane reduced the LSR amplitude in a dose-dependent and duration-dependent manner. The curve representing the LSR amplitude preservation ratio change according to sevoflurane concentration is best fitted by regression analysis using a cubic model, as the cubic equations had the largest coefficient of determination; at 15 minutes (R
2=0.76, F=78.36, P<0.05) and at 30 minutes (R
2=0.882, F=189.94, P<0.05). The inhibitory effect of sevoflurane on the LSR amplitude was greater in the first 15 minutes than in the second 15 minutes of sevoflurane administration. Sevoflurane at 1 MAC for 30 minutes mildly decreased the amplitude of the orbicularis oculi muscle wave. The latencies of the LSR and the orbicularis oculi muscle wave were not affected by sevoflurane at all MACs studied.

Conclusions:
The combination of intravenous propofol-remifentanil anesthesia with 0.5 MAC sevoflurane allows reliable intraoperative LSR monitoring in hemifacial spasm patients. Our findings support the central rather than peripheral hypothesis of the LSR.
Clinician Knowledge and Practices Related to a Patient History of Hypertensive Disorders of Pregnancy
Authors: Ford Nicole D. , Robbins Cheryl L. , Nandi Nina , Hayes Donald K. , Loustalot Fleetwood , Kuklina Elena , Ko Jean Y. 
Published: May 2022

OBJECTIVE:To describe clinician screening practices for prior hypertensive disorders of pregnancy, knowledge of future risks associated with hypertensive disorders of pregnancy, barriers and facilitators to referrals for cardiovascular disease risk evaluation in women with prior hypertensive disorders of pregnancy, and variation by clinician- and practice-level characteristics.METHODS:We used data from Fall DocStyles 2020, a cross-sectional, web-based panel survey of currently practicing U.S. clinicians. Of 2,231 primary care physicians, obstetrician–gynecologists (ob-gyns), nurse practitioners, and physician assistants invited to participate, 67.3% (n=1,502) completed the survey. We calculated the prevalence of screening, knowledge of future risks, and barriers and facilitators to referrals, and assessed differences by clinician type using χ2tests. We evaluated associations between clinician- and practice-level characteristics and not screening using a multivariable log-binomial model.RESULTS:Overall, 73.6% of clinicians screened patients for a history of hypertensive disorders of pregnancy; ob-gyns reported the highest rate of screening (94.8%). Overall, 24.8% of clinicians correctly identified all cardiovascular risks associated with hypertensive disorders of pregnancy listed in the survey. Lack of patient follow-through (51.5%) and patient refusal (33.6%) were the most frequently cited barriers to referral. More referral options (42.9%), patient education materials (36.2%), and professional guidelines (34.1%) were the most frequently cited resources needed to facilitate referrals. In the multivariable model, primary care physicians and nurse practitioners, as well as physician assistants, were more likely than ob-gyns to report not screening (adjusted prevalence ratio 5.54, 95% CI 3.24–9.50, and adjusted prevalence ratio 7.42, 95% CI 4.27–12.88, respectively). Clinicians seeing fewer than 80 patients per week (adjusted prevalence ratio 1.81, 95% CI 1.43–2.28) were more likely to not screen relative to those seeing 110 or more patients per week.CONCLUSION:Three quarters of clinicians reported screening for a history of hypertensive disorders of pregnancy; however, only one out of four clinicians correctly identified all of the cardiovascular risks associated with hypertensive disorders of pregnancy listed in the survey.
Utilization and Outcomes of Sentinel Lymph Node Biopsy for Early Endometrial Cancer
Authors: Matsuo Koji , Klar Maximilian , Nusbaum David J. , Hasanov Mir Fuad , Vallejo Andrew , Ciesielski Katharine M. , Muderspach Laila I. , Roman Lynda D. , Wright Jason D. 
Published: May 2022

OBJECTIVE:
To examine trends, characteristics, and oncologic outcomes of sentinel lymph node biopsy for early endometrial cancer.

METHODS:
This observational study queried the National Cancer Institute's Surveillance, Epidemiology, and End Results Program by examining 83,139 women with endometrial cancer who underwent primary hysterectomy with nodal evaluation for T1 disease from 2003 to 2018. Primary outcome measures were the temporal trends in utilization of sentinel lymph node biopsy and patient characteristics associated with sentinel lymph node biopsy use, assessed by multivariable binary logistic regression models. Secondary outcome measure was endometrial cancer–specific mortality associated with sentinel lymph node biopsy, assessed by propensity score inverse probability of treatment weighting.

RESULTS:
The utilization of sentinel lymph node biopsy increased from 0.2 to 29.7% from 2005 to 2018 (P<.001). The uptake was higher for women with endometrioid (0.3–31.6% between 2005 and 2018) compared with nonendometrioid (0.6–21.0% between 2006 and 2018) histologic subtypes (both P<.001). In a multivariable analysis, more recent year surgery, endometrioid histology, well-differentiated tumors, T1a disease, and smaller tumor size were independently associated with sentinel lymph node biopsy use (P<.05). Performance of sentinel lymph node biopsy was not associated with increased endometrial cancer–specific mortality compared with lymphadenectomy for endometrioid tumors (subdistribution hazard ratio [HR] 0.96, 95% CI 0.82–1.13) or nonendometrioid tumors (subdistribution HR 0.85, 95% CI 0.69–1.04). For low-risk endometrial cancer, the increase in sentinel lymph node biopsy resulted in a 15.3 percentage-point (1.4-fold) increase in surgical nodal evaluation by 2018 (expected vs observed rates, 37.8 vs 53.1%).

CONCLUSION:
The landscape of surgical nodal evaluation is shifting from lymphadenectomy to sentinel lymph node biopsy for early endometrial cancer in the United States, with no indication of a negative effect on cancer-specific survival.
Complicated multiple organ infection of Purpureocillium lilacinum and varicella-zoster virus infection in a patient with Evans’ syndrome
Authors: Hu Xiangrong , Zhang Li , Lin Qingsong , Zhang Fengkui , Zhao Xin 
Published: May 2022

Abstract

Purpureocillium lilacinum (P lilacinum) is a rare pathogenic fungus, which mainly involves immunocompromised individuals. Here, we report a case of complicated multiple-organ infections involving skin, lungs, and spleen in a 63-year-old female with Evans’ syndrome after 9 months of glucocorticoid treatment. Microbial examinations of skin biopsy and blood samples revealed P lilacinum infections. Posaconazole was effective in this patient. During anti-fungi treatment, she developed varicella-zoster virus infection and was diagnosed through next-generation sequencing examination. In conclusion, P lilacinum may affect different organ systems and is susceptible to posaconazole treatment. The molecular-based methods like microbial cell-free DNA sequencing could provide accurate and timely identification of a wide range of infections.