bluuebunny/crossref_metadata_2025_split huggingface dataset:
A weekly‐diary study of students' schoolwork motivation and parental support
Authors: Wu Yao , Hilpert Peter , Tenenbaum Harriet , Ng‐Knight Terry 
Published: August 2022

AbstractBackgroundParental support plays an important role in children's schoolwork motivation and may have been even more important during the first UK COVID‐19 pandemic lockdown because all schoolwork was completed at home. When examining the effect of parental support on children's schoolwork motivation, research has typically focused on comparing families with each other (i.e., difference between families). In reality, however, the effect unfolds as a transactional, bidirectional process between parents and children over time (i.e., a within family process). This research trend can result in imprecise conclusions about the association between parental support and schoolwork motivation.ObjectivesWe examined bidirectional effects of parental schoolwork support and children's schoolwork motivation at both the between‐family and within‐family level.MethodsThis study reports findings from a weekly‐diary study conducted during the first UK COVID‐19 school lockdown. Cross‐lagged within and between multilevel modelling was used to analyse data from UK secondary school students (N = 98) in Years 7–9.ResultsBetween‐family results show no evidence of association between motivation and parental support. Within‐family results indicate that higher motivation (assessed as higher expectations of success) predicted more support from parents. However, in contrast with predictions, weekly levels of parental support did not predict children's weekly fluctuations in motivation.ConclusionsWithin‐family results were not consistent with between‐family results. This study is novel in showing that child‐driven effects appear to be important in eliciting parental support within families over time.
Merger selection, evidence provision, and the timing of merger control
Authors: Cosnita‐Langlais Andreea , Tropeano Jean‐Philippe 
Published: August 2022

AbstractMerger control impacts the type of merger projects that are submitted, as well as the information provided by the merging parties upon assessment. In this paper, we consider the outcomes in terms of selection of merger types and evidence provision of alternative timings for merger review, pre‐ or postconsummation of the merger. We show that the selection effect induced by the ex post merger review is welfare‐improving due to the deterrence of the most anticompetitive merger projects. In contrast, the welfare impact of evidence provision under ex post assessment is ambiguous. Balancing these two effects makes possible the welfare comparison between the ex ante and the ex post merger policy enforcement.
Do voluntary commitment mechanisms improve welfare? The effect of mandatory and voluntary oaths in a social dilemma
Authors: Davis Brent J. , Jaber‐Lopez Tarek 
Published: August 2022

AbstractWe investigate whether oaths can enforce property rights in a social dilemma and increase welfare. We examine the impact of mandatory and voluntary oaths in a laboratory experiment where individuals can produce wealth, protect accumulated wealth, and take wealth from others. Individuals are more productive when oaths are mandatory compared to a no‐oath environment. Subjects’ voluntary signing oaths behave similarly to those who sign a mandatory oath. When the oath is voluntary, nonoath‐taking individuals engage in nonproductive behavior, negating the positive impact from the voluntary oath. Our results show that altering commitment mechanisms can result in varying welfare levels.
Negotiating over payments for wetland ecosystem services
Authors: Nimubona Alain‐Désiré , Pereau Jean‐Christophe 
Published: August 2022

AbstractThis paper proposes and examines the economic efficiency of novel payment schemes for the provision of wetland ecosystem services. By definition, payments for ecosystem services typically involve voluntary transactions between the beneficiaries and providers of ecosystem services. We develop a theoretical model that addresses the role that a third party—such as a social planner or government agency, acting in the interest of society—can play to ensure the optimal provision of ecosystem services. We consider different regulatory frameworks combining payments for ecosystem services with a subsidy that the third party grants to the beneficiaries or providers of ecosystem services. We compare the outcomes of the different policy mixes characterized by different levels of involvement of the third party. Of particular interest is the comparison between the outcomes of payments for ecosystem services subsidy arrangements in which the third party plays decentralized and centralized roles. Our results show, among other things, that the third party is indifferent between a negotiated payment for ecosystem services combined with a subsidy scheme and the constrained first‐best payments for ecosystem services subsidy scheme, in the presence of transaction and administrative costs. However, beneficiaries and providers may have conflicting preferences over the two payments for ecosystem services schemes.
MYO10 contributes to the malignant phenotypes of colorectal cancer via RACK1 by activating integrin/Src/FAK signaling
Authors: Ou Haibin , Wang Lili , Xi Ziyao , Shen Hui , Jiang Yaofei , Zhou Fuxiang , Liu Yu , Zhou Yunfeng 
Published: August 2022

AbstractLiver metastases still remain a major cause of colorectal cancer (CRC) patient death. MYO10 is upregulated in several tumor types; however, its significance and the underlying mechanism in CRC are not entirely clear. Here, we found that MYO10 was highly expressed in CRC tumor tissues, especially in liver metastasis tissues. MYO10 knockout reduced CRC cell proliferation, invasion, and migration in vitro and CRC metastasis in vivo. We identified RACK1 by LC‐MS/MS and demonstrated that MYO10 interacts with and stabilizes RACK1. Mechanistically, MYO10 promotes CRC cell progression and metastasis via ubiquitination‐mediated RACK1 degradation and integrin/Src/FAK signaling activation. Therefore, the MYO10/RACK1/integrin/Src/FAK axis may play an important role in CRC progression and metastasis.
Coordinating movements and beliefs: Different facets of doing things together
Authors: Białek Arkadiusz , Zubek Julian , Jackiewicz‐Kawka Martyna , Adamik Klaudia , Białecka‐Pikul Marta 
Published: August 2022

AbstractThis study investigates the relations between two forms of joint action (JA)—movement coordination (MC) and goal attainment—and theory of mind (ToM), contrasting the interactionist and traditional cognitivist views. A custom task was carried out to measure the properties of the JAs between children and their parents, while classical tasks were performed to measure first‐ and second‐order ToM. Thereafter, cross‐recurrence quantification analysis was applied to quantify participants' movements. The children were from Poland and were aged 42, 66, and 78 months (N = 297, 133 girls, White, from a large city). The results suggested that the characteristics of dyad MC influence goal attainment and are related to children's first‐order ToM (R2 = .447) but not to their second‐order ToM.
Child as method and/as childism: Conceptual–political intersections and tensions
Authors: Burman Erica 
Published: August 2022

AbstractThis article considers the related projects of child as method and childism, as two critical childhood projects attempting to re‐engage childhood studies with wider geopolitical arenas. Firstly, each model's origins in their respective subject discipline are discussed, to, secondly, highlight how this shapes convergences as well as divergences in political project. Third, there is consideration of what is at stake in key conceptual tensions identified. It is suggested that the differences of address and contrasting (disciplinary and conceptual) sites of intervention work in complementary ways to strengthen the broader project of embedding childhood studies within sociopolitical theories and practices.
The effectiveness of gabapentin and gabapentin/montelukast combination compared with dextromethorphan in the improvement of COVID‐19‐ related cough: A randomized, controlled clinical trial
Authors: Soltani Rasool , Nasirharandi Sara , Khorvash Farzin , Nasirian Maryam , Dolatshahi Kian , Hakamifard Atousa 
Published: August 2022

AbstractIntroductionCough is one of the most common presenting symptoms of COVID‐19, which can persist for weeks or months.ObjectiveThe goal of this study was to evaluate the effectiveness of gabapentin (GBT) alone and in combination with montelukast (MTL) for improving cough.MethodsIn this open‐label randomized controlled clinical trial, eligible cases were patients hospitalized with moderate to severe COVID‐19 who had cough with a Breathlessness, Cough, and Sputum Scale (BCSS) score of at least 2 based on its cough subscale. The participants were randomly assigned to three groups including two experimental groups and one control group. The first and second experimental groups received GBT and GBT/MTL, respectively, whereas the control group received dextromethorphan (DXM). Treatment duration was 5 days in all groups. Before and after the interventions, the severity of cough was evaluated using BCSS scale and Visual Analog Scale (VAS).ResultsA total of 180 patients were included; GPT, GPT/MTL, and DXM consisted of 76, 51, and 53 patients, respectively. There was no significant difference between the three groups in terms of age, gender, and comorbidities (P > 0.05). Regarding BCSS and VAS scores, there was significant reduction from the baseline values in all groups (P < 0.0001), with the change rate being significantly higher in DXM group. The amount of reduction of BCSS in the GPT/MTL group was significantly more than the GPT group, whereas there was no significant difference between the two groups regarding VAS score. Although the duration of hospitalization differed between the groups with the GPT/MTL group having the shortest duration, the difference was statistically significant only between the GPT and GPT/MTL groups (P < 0.0001).ConclusionGPT, both alone and in combination with MTL, improves cough frequency and severity in hospitalized patients with COVID‐19, with the combination being more efficacious. This regimen may be useful in patients who cannot tolerate opioids.
Integrating real‐world data to accelerate and guide drug development: A clinical pharmacology perspective
Authors: Zhao Xiaochen , Iqbal Shahed , Valdes Ivelisse L. , Dresser Mark , Girish Sandhya 
Published: August 2022

AbstractPharmaceutical products in the current accelerated drug development landscape can benefit from tools beyond data generated from randomized control trials. We have seen an abundance of real‐world data (RWD) and real‐world evidence, driven by the digitalization of healthcare systems and an increased awareness that has inspired a heightened interest in their potential use. Literature review suggest leveraging RWD as a promising tool to answer key questions in the areas of clinical pharmacology and translational science. RWD may increase our understanding regarding the impact of intrinsic (e.g., liver, renal impairment, or genetic polymorphisms) and extrinsic (e.g., food consumption or concomitant medications) factors on the clearance of administered drugs. Changes in clearance may lead to clinically relevant changes in drug exposure that may require clinical management strategies, such as change in dose or dosing regimen. RWD can be leveraged to potentially bridge the gaps among research, development, and clinical care. This paper highlights promising areas of how RWD have been used to complement clinical pharmacology throughout various phases of drug development; case examples will include dose/regimen extrapolation, dose adjustments for special populations (organ impairment, pediatrics, etc.), and pharmacokinetic/pharmacodynamic models to assess impact of prognostic factors on outcomes. In addition, this paper will also juxtapose limitations and promises of utilizing RWD to answer key scientific questions in drug development and articulate challenges posed by quality issues, data availability, and integration from various sources as well as the increased need for multidimensional‐omics data that can better guide the development of personalized and predictive medicine.
Navigating the grey: Experiences of incremental cannabis reform in Australia
Authors: Barrett Liz , Mellor Richard , Ritter Alison , McLauchlan Laura , Kearnes Matthew 
Published: August 2022

AbstractIntroduction and AimsThere have been many changes to cannabis laws across the globe, some dramatic but more often incremental. This study explored the experiences after an incremental cannabis law reform in the Australian Capital Territory, Australia.MethodSemi‐structured interviews (n = 30) were conducted in March and April 2021, 14 months after the introduction of cannabis law reform, with people aged 18 and over who had grown and/or consumed cannabis in the previous 12 months. Participants were asked about recent and past cannabis use, growing cannabis and changes to their practices after the introduction of the legislation.ResultsIncremental cannabis law change resulted in regulatory grey areas. How people interpreted and navigated such grey areas were connected to their relative privileges, circumstances and histories. Those who were highly policed were more likely to experience the grey areas negatively. Those who were not highly policed found the grey areas confusing or ‘half‐arse’ (insufficiently executed), but mostly experienced the new laws positively through new cannabis cultivation or perceived reduction in stigma and fear of arrest. Those with self‐identified privilege were unconcerned with grey areas of the legislation.Discussion and ConclusionIncremental policy change can result in grey areas that require some navigation. Vulnerable populations appear less likely to experience the full benefits of such incremental drug law reform. It is vital to attend to the inequities that can arise from incremental law reform so that positive experiences are shared across the population regardless of relative privilege.
Lichen planus in Germany – epidemiology, treatment, and comorbidity. A retrospective claims data analysis
Authors: Schruf Eva , Biermann Mona HC , Jacob Josephine , Häckl Dennis , Reinhardt Maximilian , Hertl Michael , Wohlrab Johannes 
Published: August 2022

SummaryBackground and objectivesLichen planus (LP) is a chronic inflammatory skin disease and is a major burden for affected patients. However, data on this condition are scarce. This study aims to expand the knowledge on the epidemiology and treatment patterns of LP using German health claims data.Patients and MethodsThis retrospective observational study was based on the InGef research database. Prevalent and incident LP patients were identified in the years 2015 and 2018. Descriptive statistics were calculated for demographic characteristics, treatment patterns, and comorbidity.ResultsThe prevalence of LP was 95.9 and the incidence was 20.1 per 100,000 individuals in 2018, corresponding to 79,605 prevalent LP cases in Germany. The first LP diagnosis was generally documented by a dermatologist or a primary care physician. Three‐quarters of the incident and half of the prevalent patients received topical therapy, mostly without further systemic therapy. Comorbidity in LP patients was consistent with previously known associations.ConclusionsAvailable treatment options remain limited, underscoring the unmet need for safe and efficacious systemic treatment modalities. Lichen planus is frequently accompanied by clinically relevant systemic comorbidity. Taken together, these observations may improve our understanding of the burden of this disease and increase diagnostic awareness among clinicians.
Prevalence, characteristics, and impact of adverse events in 34 Madrid hospitals. The ESHMAD study
Authors: Valencia‐Martín José L. , Vicente‐Guijarro Jorge , San Jose‐Saras Diego , Moreno‐Nunez Paloma , Pardo‐Hernández Alberto , Aranaz‐Andrés Jesús María ,   ESHMAD Director Group and external advisers
Published: August 2022

AbstractIntroductionAdverse Events (AE) are one of the main problems in healthcare. Therefore, many policies have been developed worldwide to mitigate their impact. The Patient Safety Incident Study in Hospitals in the Community of Madrid (ESHMAD) measures the results of them in the region.MethodsCross‐sectional study, conducted in May 2019, in hospitalised patients in 34 public hospitals using the Harvard Medical Practice Study methodology. A logistic regression model was carried out to study the association of the variables with the presence of AE, calibrated and adjusted by patient.ResultsA total of 9975 patients were included, estimating a prevalence of AE of 11.9%. A higher risk of AE was observed in patients with surgical procedures (OR[CI95%]: 2.15[1.79 to 2.57], vs. absence), in Intensive Care Units (OR[CI95%]: 1.60[1.17 to 2.17], vs. Medical) and in hospitals of medium complexity (OR[CI95%]: 1.45[1.12 to 1.87], vs. low complexity). A 62.6% of AE increased the length of the stay or it was the cause of admission, and 46.9% of AE were considered preventable. In 11.5% of patients with AE, they had contributed to their death.ConclusionsThe prevalence of AE remains similar to the previously estimated one in studies developed with the same methodology. AE keep leading to longer hospital stays, contributing to patient's death, showing that it is necessary to put focus on patient safety again. A detailed analysis of these events has enabled the detection of specific areas for improvement according to the type of care, centre and patient.
A detailed redescription of the mesoderm/neural crest cell boundary in the murine orbitotemporal region integrates the mammalian cranium into a pan‐amniote cranial configuration
Authors: Kuroda Shunya , Adachi Noritaka , Kuratani Shigeru 
Published: August 2022

AbstractThe morphology of the mammalian chondrocranium appears to differ significantly from those of other amniotes, since the former possesses uniquely developed brain and cranial sensory organs. In particular, a question has long remained unanswered as to the developmental and evolutionary origins of a cartilaginous nodule called the ala hypochiasmatica. In this study, we investigated the embryonic origin of skeletal elements in the murine orbitotemporal region by combining genetic cell lineage analysis with detailed morphological observation. Our results showed that the mesodermal embryonic environment including the ala hypochiasmatica, which appeared as an isolated mesodermal distribution in the neural crest‐derived prechordal region, is formed as a part of the mesoderm that continued from the chordal region during early chondrocranial development. The mesoderm/neural crest cell boundary in the head mesenchyme is modified through development, resulting in the secondary mesodermal expansion to invade into the prechordal region. We thus revealed that the ala hypochiasmatica develops as the frontier of the mesodermal sheet stretched along the cephalic flexure. These results suggest that the mammalian ala hypochiasmatica has evolved from a part of the mesodermal primary cranial wall in ancestral amniotes. In addition, the endoskeletal elements in the orbitotemporal region, such as the orbital cartilage, suprapterygoid articulation of the palatoquadrate, and trabecula, some of which were once believed to represent primitive traits of amniotes and to be lost in the mammalian lineage, have been confirmed to exist in the mammalian cranium. Consequently, the mammalian chondrocranium can now be explained in relation to the pan‐amniote cranial configuration.
Average Rank and Adjusted Rank Are Better Measures of College Student Success than GPA
Authors: Wittman Donald 
Published: August 2022

AbstractI show that there are better measures of student college performance than grade point average (GPA) by undertaking a fine‐grained empirical investigation of grading within a large public university. The value of using GPA as a measure of comparative performance is undermined by academically weaker students taking courses where the grading is more generous. In fact, college courses composed of weaker performing students (whether measured by their relative performance in other classes, SAT scores, or high school GPA) have higher average grades. To partially correct for idiosyncratic grading across classes, alternative measures, student class rank and the student's average class rank, are introduced. In comparison to a student's lower‐division grade, the student's lower‐division rank is a better predictor of the student's grade in the upper‐division course. Course rank and course grade are adjusted to account for different levels of academic competitiveness across courses (more precisely, student fixed‐effects are derived). SAT scores and high school GPA are then used to predict college performance. Higher explained variation (R2) is obtained when the dependent variable is average class rank rather than GPA. Still higher explained variation occurs when the dependent variable is adjusted rank.
Current status and first detection of Xylosandrus germanus (Coleoptera: Curculionidae: Scolytinae) in live trees in the Iberian Peninsula
Authors: Riba‐Flinch Josep M. , Garreta Anna , Aymamí Anna , Lumbierres Belén , Mas Hugo , Gallego Diego 
Published: August 2022

AbstractThe black stem borer Xylosandrus germanus (Blandford, 1894) (Coleoptera: Curculionidae: Scolytinae) is a species native to Eastern Asia that has invaded 24 countries worldwide, including 21 European countries, the USA, Canada and New Zealand. On the Iberian Peninsula it was recorded for the first time in traps placed in the Basque Country (Northern Spain) in 2003, but its host plants were unknown. In the present work, three populations of X. germanus are recorded in the east of Spain in Girona, Tarragona and Valencia provinces (Automomous Community of Catalonia, and Valencia, respectively). Specimens were collected in traps and on host plants, showing a wider distribution range now including the east and north‐east of the Iberian Peninsula. Infested carob trees (Ceratonia siliqua) were found in agricultural and urban green areas in Tarragona. Ceratonia siliqua is therefore reported here as a new host of X. germanus.