bluuebunny/crossref_metadata_2025_split huggingface dataset:
Multimaterial Glass Fiber Probe for Deep Neural Stimulation and Detection
Authors: Dai Yi , Du Minghui , Huang Lu , Zheng Jiajun , Wei Lei , Qiu Jianrong , Ren Chaoran , Zhou Shifeng 
Published: November 2022

AbstractThe ability for simultaneous modulation and monitoring of neural activities in deep tissues and at the single‐cell level merits significant scientific and technological potential, yet is met with limited success using conventional probes. Here, a new type of tiny multimaterial glass fiber probe is proposed and successfully constructed with the combination of robust mechanical response, strong light‐delivering ability, and excellent electrochemical properties, based on high throughput and scalable co‐drawing strategy. Guided by the multimaterial integration principle, the configuration of the probes can be rationally tuned including their material combination, physical size, the number and spatial distribution of the electrode, and even the waveguide structure. The bending stiffness, optical loss, and electrical impedance can be controlled to be larger than 4900 N m−1 and as small as 0.01306 dB cm−1 and 19.63 MΩ µm2 at 1 kHz, respectively. To prove the utility, it is demonstrated that the probes allow for simultaneous deep neural stimulation and detection for more than 2 weeks at a single cellular level. This work not only promotes the development of neuroscience and brain science through the ability to manipulate neural circuits in the deep brain but also provides new directions for expanding the scope of functional fibers.
Updates to the MANAGE database to facilitate regional analyses of nutrient runoff
Authors: Harmel R. Daren , Kleinman Peter , Hopkins Austin P. , Millhouser Paul , Ippolito Jim A. , Sahoo Debabrata 
Published: November 2022

AbstractThe first compilation of nutrient export coefficients for specific land uses in the United States was completed in 1980. Building off that effort, the “Measured Annual Nutrient loads from AGricultural Environments” (MANAGE) database was developed in 2006 to summarize annual field‐scale nitrogen (N) and phosphorus (P) runoff data from agricultural land uses. It also presents descriptive data such as land use, tillage, conservation practices, soil type, soil test P, slope, and fertilizer formulation, rate, and application method, along with runoff, precipitation, and soil erosion. Here, we update MANAGE to facilitate regional analyses, adding 27 studies and Level II ecoregion delineations for each of the 94 studies such that data are now available from 11 of the 50 North American Level II ecoregions, representing the major U.S. agricultural regions. This contemporary data repository is freely available from USDA Ag Data Commons to support scientific analyses, model evaluations, and management and policy decisions.
Species identification in fish meal from urban fisheries biomass with DNA metabarcoding analysis
Authors: Ido Atsushi , Miura Takeshi 
Published: November 2022

AbstractAs demand for ingredients for fish feed has increased, fish meal and fish oil converted from fisheries by‐products have gained importance as ingredients to replace forage fish. It has been demonstrated that high quality fish oil and fish meal made from urban fisheries biomass, which is fisheries by‐products collected downstream in the seafood supply chain, could be produced. However, a problem with this is that traceability is not ensured due to the wide variety of fish used. Here, a DNA metabarcoding method for monitoring biodiversity was applied to fish meal from the fisheries biomass produced in Japan. This method was shown to be able to detect fish species present at more than 0.001% by weight, and quantitatively detect more than 0.01% by weight; we successfully detected 81–122 species in amplicon sequence variants obtained from fish meals collected throughout a 1‐year period. Bray–Curtis similarity classified the samples into two clusters: one in spring to autumn and one in winter, indicating a considerable influence of skipjack tuna (Katsuwonus pelamis) on the fish constituting the fisheries biomass. Among the detected fish species present at more than 0.01% in fish meal, southern bluefin tuna (Thunnus maccoyii) and Japanese eel (Anguilla japonica) might be of concern for their stock and illegal, unreported, and unregulated fishery risks. However, from the food recycling perspective, fish oil and fish meal from the fisheries biomass should be utilized, as long as these fish comprised in the biomass are not caught for feed purposes.
Who buys regional fresh milk brands? An analysis of German household data
Authors: Knuck Janina , Hess Sebastian 
Published: November 2022

AbstractFarmstead dairies produce, process, and market their milk locally under their own brands. Farmstead dairy brands (FDB) are thus competing against private labels and manufacturer brands, whose milk often comes from different areas and which are sold nationwide. Even though FDB cannot benefit from industrial economies of scale, they represent a small but successful and growing segment where demand has been rising for years, even though the demand for milk in general has been rather stagnant. Based on data from a German household panel it is evident that marketing of FDB milk through retail stores meets the trend for regional products and some consumers are increasingly willing to pay for local and regionally produced food. The results of a zero‐inflated negative binomial model revealed that middle‐aged, high income, and organic buying behaviors significantly influenced the purchase frequency of FDB milk in food retail. [EconLit Citations: Q130, D120, C23].
Non‐invasive mixing time estimation in unbaffled stirred tank: An ultrasonic approach
Authors: Mukherjee Debmalya , Sen Nirvik , Singh Krishna Kumar , Saha Shilpi , Mayya Anuradha , Shenoy Kalsanka Trivikram 
Published: November 2022

AbstractEstimation of mixing time is an essential aspect in characterization of stirred tanks. In this work, we report a novel, non‐invasive technique to estimate mixing time in an unbaffled stirred tank using a contact type ultrasonic sensor. Variation in speed of sound in stirred tank is measured by ultrasound and is used to determine the mixing time of solutions. A sensing time of 16.6 ms (~60 Hz) is achieved which leads to an estimation of the mixing process dynamics under forced vortex conditions. The method is validated against colorimetric technique using a dye. The technique is thereafter used to determine mixing time under different operating (impeller speed) and geometrical (impeller design, vessel diameter, and off‐bottom clearance) conditions. Though the results presented are specific to unbaffled stirred tank, the method reported is general and can be used in any kind of stirred tank.
Sustainable and Selective Modern Methods of Noble Metal Recycling
Authors: Zupanc Anže , Install Joseph , Jereb Marjan , Repo Timo 
Published: November 2022

AbstractNoble metals exhibit broad arrange of applications in industry and several aspects of human life which are becoming more and more prevalent in modern times. Due to their limited sources and constantly and consistently expanding demand, recycling of secondary and waste materials must accompany the traditional mineral extractions. This Minireview covers the most recent solvometallurgical developments in regeneration of Pd, Pt, Rh, Ru, Ir, Os, Ag and Au with emphasis on sustainability and selectivity. Processing—by selective oxidative dissolution, reductive precipitation, solvent extraction, co‐precipitation, membrane transfer and trapping to solid media—of eligible multi‐metal substrates for recycling from waste printed circuit boards to end‐of‐life automotive catalysts are discussed. Outlook for possible future direction for noble metal recycling is proposed with emphasis on sustainable approaches.
Schlenks Vermächtnis – Methyllithium unter der Lupe
Authors: Lebon Jakob , Mortis Alexandros , Maichle‐Mössmer Cäcilia , Manßen Manfred , Sirsch Peter , Anwander Reiner 
Published: November 2022

AbstractKommerziell erhältliche Stammlösungen von Organolithiumverbindungen sind vielfach eingesetzte Reagenzien in der Organischen und Metallorganischen Chemie. Solche Lösungen sind jedoch von “Natur aus” mit Lithiumhalogenidsalzen verunreinigt, die viele Syntheseprotokolle und Aufreinigungsprozesse erheblich einschränken. In dieser Arbeit beschreiben wir die Isolierung von chloridfreiem Methyllithium mithilfe von K[N(SiMe3)2] als Halogenidfällungsreagenz. Der Einfluss von definierten LiCl‐Verunreinigungen auf die 7Li‐NMR chemische Verschiebung wurde systematisch untersucht und quantifiziert. Die strukturellen Parameter des neuen chloridfreien Methyllithiumkomplexes [(Me3TACN)LiCH3] wurden mit der halogenidverunreinigten Variante und monomerem Lithiumchlorid [(Me3TACN)LiCl] verglichen.
(BO)2‐Doped Tetrathia[7]helicene: A Configurationally Stable Blue Emitter
Authors: Menduti Luigi , Baldoli Clara , Manetto Simone , Bolte Michael , Lerner Hans‐Wolfram , Longhi Giovanna , Villani Claudio , Licandro Emanuela , Wagner Matthias 
Published: November 2022

AbstractHelicenes combine two central themes in chemistry: extended π‐conjugation and chirality. Hetero‐atom doping preserves both characteristics and allows modulation of the electronic structure of a helicene. Herein, we report the (BO)2‐doped tetrathia[7]helicene1, which was prepared from 2‐methoxy‐3,3′‐bithiophene in four steps.1is formally derived by substituting two (Mes)B−O moieties in place of (H)C=C(H) fragments in two benzene rings of the parent tetrathia[7]helicene. X‐ray crystallography revealed a dihedral angle of 50.26(9)° between the two terminal thiophene rings. The (P)‐/(M)‐1enantiomers were separated by chiral HPLC and are configurationally stable at room temperature. The experimentally determined enantiomerization barrier of 27.4±0.1 kcal mol−1is lower than that of tetrathia[7]helicene (39.4±0.1 kcal mol−1). The circular dichroism spectra of (P)‐ and (M)‐1show a perfect mirror‐image relationship.1is a blue emitter (λem=411 nm) with a photoluminescence quantum efficiency ofΦPL=6 % (cf. tetrathia[7]helicene:λem≈405 nm,ΦPL=5 %).
Co‐Intercalation of Dual Charge Carriers in Metal‐Ion‐Confining Layered Vanadium Oxide Nanobelts for Aqueous Zinc‐Ion Batteries
Authors: Lv Tingting , Zhu Guoyin , Dong Shengyang , Kong Qingquan , Peng Yi , Jiang Shu , Zhang Guangxun , Yang Zilin , Yang Shengyang , Dong Xiaochen , Pang Huan , Zhang Yizhou 
Published: November 2022

AbstractVanadium‐based oxides with high theoretical specific capacities and open crystal structures are promising cathodes for aqueous zinc‐ion batteries (AZIBs). In this work, the confined synthesis can insert metal ions into the interlayer spacing of layered vanadium oxide nanobelts without changing the original morphology. Furthermore, we obtain a series of nanomaterials based on metal‐confined nanobelts, and describe the effect of interlayer spacing on the electrochemical performance. The electrochemical properties of the obtained Al2.65V6O13 ⋅ 2.07H2O as cathodes for AZIBs are remarkably improved with a high initial capacity of 571.7 mAh ⋅ g−1 at 1.0 A g−1. Even at a high current density of 5.0 A g−1, the initial capacity can still reach 205.7 mAh g−1, with a high capacity retention of 89.2 % after 2000 cycles. This study demonstrates that nanobelts confined with metal ions can significantly improve energy storage applications, revealing new avenues for enhancing the electrochemical performance of AZIBs.
Peptide Amphiphile Mediated Co‐assembly for Nanoplasmonic Sensing
Authors: Jin Zhicheng , Li Yi , Li Ke , Zhou Jiajing , Yeung Justin , Ling Chuxuan , Yim Wonjun , He Tengyu , Cheng Yong , Xu Ming , Creyer Matthew N. , Chang Yu‐Ci , Fajtová Pavla , Retout Maurice , Qi Baiyan , Li Shuzhou , O'Donoghue Anthony J. , Jokerst Jesse V. 
Published: November 2022

AbstractAromatic interactions are commonly involved in the assembly of naturally occurring building blocks, and these interactions can be replicated in an artificial setting to produce functional materials. Here we describe a colorimetric biosensor using co‐assembly experiments with plasmonic gold and surfactant‐like peptides (SLPs) spanning a wide range of aromatic residues, polar stretches, and interfacial affinities. The SLPs programmed in DDD−(ZZ)x−FFPC self‐assemble into higher‐order structures in response to a protease and subsequently modulate the colloidal dispersity of gold leading to a colorimetric readout. Results show the strong aggregation propensity of the FFPC tail without polar DDD head. The SLPs were specific to the target protease, i.e., Mpro, a biomarker for SARS‐CoV‐2. This system is a simple and visual tool that senses Mproin phosphate buffer, exhaled breath condensate, and saliva with detection limits of 15.7, 20.8, and 26.1 nM, respectively. These results may have value in designing other protease testing methods.
Palladium‐Catalyzed Ring‐Closing Aminoalkylative Amination of Unactivated Aminoenynes
Authors: Zou Suchen , Yu Bangkui , Huang Hanmin 
Published: November 2022

AbstractAn efficient strategy for preventing the β‐hydride elimination of alkylpalladium species by ligation of the palladium with adjacent amino‐group was developed, which enabled a novel palladium‐catalyzed ring‐closing aminoalkylative amination of unactivated aminoenynes. The reaction is amenable to aminals, as well as aliphatic aldehydes with secondary amines, which provides straightforward access to structurally diverse exocyclic allenic amines bearing 5 to 12‐memberedN‐heterocycles. With chiral phosphoramidite‐ligated palladium complex as the catalyst, an enantioselective variant was achieved with up to 93 % ee. Simultaneously, synthetic transformations of the chiral products were also conducted to afford structurally unique spirodiamines including one pharmaceutically active molecule via axial‐to‐central chirality transfer.
Effect of polydopamine deposition on wool fibers on the construction of melanin
Authors: Huang Hongbo , Zhang Wen , Han Xiaoyu , Han Zongbao , Song Dengpeng , Li Wenbin , Li Zhujun , Wang Yunli , Xu Weilin 
Published: November 2022

AbstractThe use of dopamine to synthesize melanin as a natural dye on fabrics has the disadvantages of complicated processing, long processing time, and high cost. This study simplifies the processing conditions of the oxidative polymerization of dopamine and develops wool fabric melanin coatings with different finishing effects by adjusting the reaction time. The results of computer color matching, ultraviolet (UV) protection properties, and color fastness indicated that the treated wool fibers were effectively dyed, and they achieved UV resistance properties comparable to those realized in other studies in a relatively short time. The degree of lightness (L) and UV protection factor of the treated fabric reached up to 13.3 and 80+, respectively. Samples W/PDA 60 and W/PDA 120 absorbed more than 95% of the UV light. The color fastness was greater than Grade 4. The Fourier infrared spectrum and X‐ray diffraction studies revealed that the chemical and crystalline structures of the wool fiber did not change significantly after the treatment. The breaking strength of samples W/PDA 60 and W/PDA 120 was about 50% higher than that of the original wool fabric. This efficient and simple method provides a feasible and promising solution for the color deepening and UV finishing of high value‐added wool products. It can be a potential choice for upgrading the printing and dyeing industries from the perspective of ecological protection.
Gene Expression and Autoantibody Analysis Revealing Distinct Ancestry‐Specific Profiles Associated With Response to Rituximab in Refractory Systemic Lupus Erythematosus
Authors: Carter Lucy M. , Alase Adewonuola , Wigston Zoe , Psarras Antonios , Burska Agata , Sutton Emily , Yusof Md Yuzaiful Md , Reynolds John A. ,   The MASTERPLANS Consortium, McHugh Neil , Emery Paul , Wittmann Miriam , Bruce Ian N. , Vital Edward M. 
Published: November 2022

ObjectiveGene expression profiles are associated with the clinical heterogeneity of systemic lupus erythematosus (SLE) but are not well studied as biomarkers for therapy. We studied gene expression and response to rituximab in a multiethnic UK cohort who were refractory to standard therapy.MethodsWe evaluated baseline expression levels of transcripts known to associate with clinical features of SLE using a 96‐probe TaqMan array and whole blood samples from 213 patients with active SLE who had been prospectively enrolled in the British Isles Lupus Assessment Group (BILAG) Biologics Register. We measured autoantibodies using immunoprecipitation and enzyme‐linked immunosorbent assays. We determined responses to first‐cycle rituximab at 6 months from treatment start in 110 SLE patients by assessing BILAG 2004 disease activity.ResultsInterferon gene expression scores were lower in patients of European ancestry than in all other ancestry groups. The relationship between blood interferon gene expression scores and scores annotated to plasmablasts, neutrophils, myeloid lineage, inflammation, and erythropoiesis differed between patients of European and non‐European ancestries. Hierarchical clustering revealed 3 distinct non‐European ancestry patient subsets with stratified responses to rituximab that were not explained by sociodemographic and clinical variables, with responses lowest in an interferon‐low, neutrophil‐high cluster and highest in a cluster with high expression levels across all signatures (P < 0.001). Clusters in European ancestry patients did not predict response to rituximab but segregated patients by global disease activity and renal involvement. In both ancestral groups, interferon‐high clusters were associated with U1 RNP/Sm antibodies.ConclusionAncestry appears central to the immunologic and clinical heterogeneity in SLE. These results suggest that ancestry, disease activity, and transcriptional signatures could each assist in predicting the effectiveness of B cell depletion therapies.image
Low Concentrations of C5a Complement Receptor Antibodies Are Linked to Disease Activity and Relapse in Antineutrophil Cytoplasmic Autoantibody–Associated Vasculitis
Authors: Klapa Sebastian , Müller Antje , Koch Andreas , Kerstein‐Stähle Anja , Kähler Wataru , Heidecke Harald , Schinke Susanne , Huber‐Lang Markus , Nitschke Martin , Pitann Silke , Augustin Solveig , Karsten Christian M. , Riemekasten Gabriela , Lamprecht Peter 
Published: November 2022

ObjectiveTo examine concentrations of circulating antibodies targeting C3a and C5a complement receptors in antineutrophil cytoplasmic autoantibody (ANCA)–associated vasculitis (AAV) and analyze their association with disease activity.MethodsConcentrations of antibodies against C3a and C5a complement receptors (anti‐C3aR and anti‐C5aR) and plasma complement fragments C3a and C5a were determined in patients with AAV (n = 110; granulomatosis with polyangiitis [GPA; n = 82] or microscopic polyangiitis [MPA; n = 28]), systemic lupus erythematosus (SLE) patients as disease controls (n = 36), and healthy donors (n = 220). C3aR and C5aR expression by circulating neutrophils, monocytes, and T cells was analyzed using flow cytometry. Clinical data were assessed at time of serum sampling and during follow‐up for 60 months.ResultsIn AAV, anti‐C3aR and anti‐C5aR antibodies were decreased (P = 0.0026 and P ≤ 0.0001, respectively). In remission, anti‐C3aR antibody concentrations rose to values comparable to healthy donors, whereas anti‐C5aR antibody concentrations did not. In GPA, anti‐C5a and anti‐C5aR antibody concentrations inversely correlated with each other (r = −0.6831, P = 0.0127). In newly diagnosed GPA, decreased concentrations of anti‐C5aR antibodies but not anti‐C3aR antibodies were associated with disease activity (P = 0.0009). Moreover, low anti‐C5aR antibodies were associated with relapse in GPA (hazard ratio 3.54, P = 0.0009) and MPA (hazard ratio 4.41, P = 0.0041). The frequency of C5aR‐expressing cells within T cell populations was increased in GPA (P = 0.0021 for CD4+ T cells; P = 0.0118 for CD8+ T cells), but not in MPA.ConclusionLow concentrations of anti‐C5aR antibodies reflect disease activity and are associated with an increased risk for relapse in AAV.image
Thermodynamic Differentiation of the Two Sides of Azabuckybowl through Complexation with Square Planar Platinum(II)
Authors: Nishimoto Mikey , Uetake Yuta , Yakiyama Yumi , Sakurai Hidehiro 
Published: November 2022

AbstractThe precise control of the two faces, concave/convex faces, is an attractive challenge to realizing novel dynamic molecular systems. Herein, we report the synthesis, X‐ray crystal structure, and bowl‐to‐bowl inversion behavior of a platinum complex with azabuckybowl as a monodentate ligand. X‐ray crystallography revealed that the azabuckybowl is orthogonally coordinated to the plane containing the Pt center and other ligands. One and two‐dimensional NMR studies have also confirmed that this complex was observed as mixtures of two isomers, although the isomeric ratio was highly biased. Theoretical calculations indicate that the difference in thermodynamic stability of these isomers is due to the direction of the concave/convex face of an azabuckybowl ligand.
Poly‐pathways metabolomics for high‐yielding cordycepin of Cordyceps militaris
Authors: Yu Jinyan , Sun Min , Wang Xiaoyu , Qi Dongmei , Han Chunchao 
Published: November 2022

AbstractCordycepin is an important quality control marker in Cordyceps militaris. This study aimed to explain the metabolic mechanisms for high‐yielding cordycepin of C. militaris. In this study, high‐yielding strains of cordycepin were obtained by ultraviolet mutagenesis, and the polysaccharide and protein contents were also changed. In high‐yielding strains, the protein content significantly increased, whereas the polysaccharide content decreased. Simultaneously, metabolic differences for high‐ and low‐yielding cordycepin strains were detected by metabolomics. Metabolomics results showed that the relative content of most metabolites decreased in high‐yielding cordycepin strains. Various metabolic pathways have been altered in high‐yielding cordycepin strains, such as the citric acid cycle, purine metabolism, and pyrimidine metabolism, leading to an increase in cordycepin content. In addition, changes in metabolic poly‐pathways related to polysaccharide and protein synthesis, such as galactose metabolism and amino acid metabolism, promoted an increase in cordycepin content. This study analyzes the high yield of cordycepin in C. militaris at the metabolic level and provides a theoretical basis for further increasing cordycepin content.