bluuebunny/crossref_metadata_2025_split huggingface dataset:
CHST4 might promote the malignancy of cholangiocarcinoma
Authors: Zhang Guanran , Liu Xuyue , Jian Aiwen , Zheng Kexin , Wang Haiyan , Hao Jing , Zhi Sujuan , Zhang Xiaoli 
Published: March 2022

BackgroundCholangiocarcinoma (CCA) is reported as an aggressive cancer which leads to high mortality and no effective therapeutic target has yet been discovered. Surgical resection is the main method to treat patients with CCA. However, only one-third of CCA patients have the opportunity to accept the operation, leading to poor prognosis for CCA patients. Therefore, it is necessary to search for new therapeutic targets of CCA or core genes involved in the happening and growth of CCA.AimIn this study, we utilized bioinformatics technology and accessed to several medical databases trying to find the core genes of CCA for the purpose of intervening CCA through figuring out an effective curative target.MethodsFirstly, three differentially expressed genes (DEGs) were discovered from GEPIA, and by further observing the distribution and gene expression, CHST4 was obtained as the core gene. Afterwards, correlated genes of CHST4 in CCA were identified using UALCAN to construct a gene expression profile. We obtained PPI network by Search Tool for the Retrieval of Interacting Networks Genes (STRING) and screened core genes using cytoscape software. Functional enrichment analyses were carried out and the expression of CHST in human tissues and tumors was observed. Finally, a CCA model was established for qPCR and staining validation.ResultsThree differentially expressed genes (DEGs), CHST4, MBOAT4 and RP11-525K10.3, were obtained. All were more over-expressed in CCA samples than the normal, among which the change multiple and the gene expression difference of CHST4 was the most obvious. Therefore, CHST4 was selected as the core gene. We can see in our established protein–protein interaction (PPI) network that CHST4 had the highest degree of connectivity, demonstrating its close association with CCA. We found that genes were mainly enriched in CCs in the PPI networks genes which shows functional enrichment analysis results, including golgi lumen, extracellular space and extracellular region. CHST4 was found very specifically expressed in the bile duct and was significantly different from that in normal tissues. The overexpression of CHST4 was further verified in the established animal model of TAA-induced CCA in rats. Quantitative PCR (qPCR) demonstrated that CHST4 was significantly overexpressed in tumor tissues, verifying the role of CHST4 as the core gene of CCA.ConclusionCHST4 was increasingly expressed in CCA and CHST4 is worth being studied much further in the intervention of CCA.
Changes in fetal growth restriction and retinopathy of prematurity during the coronavirus disease 2019 pandemic: A cross-sectional study
Authors: Obata Shumpei , Matsumoto Riko , Kakinoki Masashi , Tsuji Shunichiro , Murakami Takashi , Yanagi Takahide , Maruo Yoshihiro , Ohji Masahito 
Published: March 2022

Purpose
To investigate changes in the number of preterm infants, low birth weight infants, and infants with fetal growth restriction (FGR) or retinopathy of prematurity (ROP) during the coronavirus disease 2019 (COVID-19) pandemic.

Methods
In this retrospective cross-sectional study, we reviewed the medical records of infants born and admitted to the neonatal intensive care unit and growth care unit of Shiga University of Medical Science Hospital before the COVID-19 pandemic (April 1, 2019 to September 30, 2019) and during the pandemic (April 1, 2020 to September 30, 2020). Medical records of infants’ mothers were also collected. Preterm infants, low birth weight infants, infants with FGR, infant and maternal factors associated with FGR, and infants requiring treatment for ROP were compared between the two periods.

Results
There were fewer infants born at < 28 weeks of gestation, infants with birth weight < 1,500 g, and infants with FGR during the pandemic period than the pre-pandemic period (pre-pandemic: n = 4 vs. during pandemic: n = 0, P = 0.048; pre-pandemic: n = 15 vs. during pandemic: n = 6, P = 0.02; and pre-pandemic: n = 31 vs. during pandemic: n = 12, P = 0.0002, respectively). There were no significant differences in any infant or maternal factors associated with FGR. The number of infants requiring treatment for ROP decreased during the pandemic, although this difference was not statistically significant (pre-pandemic: n = 3 vs. during pandemic: n = 0, P = 0.08).

Conclusions
Our findings showed a reduction in the number of infants with FGR during the COVID-19 pandemic. The number of infants born at < 28 weeks of gestation and infants with birth weight < 1,500 g also decreased during the pandemic period. There was a trend toward fewer infants requiring treatment for ROP during the COVID-19 pandemic.
Interventions for cancer screening among Chinese Americans: A systematic review and meta-analysis
Authors: Lei Fang , Zheng Ying , Lee Eunice 
Published: March 2022

BackgroundCancer is the leading cause of death among Chinese Americans (CAs). Although death rates of cancers can be significantly reduced by screening cancers at an early stage, cancer screening (CS) rates are low among CAs. Interventions on CS may increase the uptake rates of CS and help to decrease the death rates of cancers in CAs.ObjectivesThis study aims to summarize the intervention methods on CS among CAs and compare effects of various intervention methods on the outcomes of CS, including knowledge levels of CS, intentions to complete CS, and actual completions of CS.MethodsA systematic review and meta-analysis design was used. Keyword searching was conducted on PubMed, Google Scholar, PsycINFO, and CINAHL. Inclusion and exclusion criteria were applied. The PEDro scale was used to evaluate the quality of the studies. Data was analyzed using Review Manager Version 5.4 software. Random effect model and subgroup analyses were conducted.ResultsThe search yielded 13 eligible studies. All of the reviewed interventions were culturally tailored. Systematic review results were categorized by intervention delivery objects, intervention led, intervention contact, intervention types, and intervention focus according to group consensus. Meta-analysis results showed that the interventions on CS had a positive effect on all outcomes, including a 1.58 (95% CI, 1.17–2.14; P = 0.003), 1.78 (95% CI, 1.27–2.48; P = 0.0007), and 1.72 (95% CI, 1.22–2.42; P = 0.002) effect on knowledge of CS, intentions to complete CS, and completions of CS, respectively, compared to the control group. The subgroup analysis suggested that physician-led, individual-based, face-to-face client-focused interventions with multiple components increased CS among CAs, with the OR ranging from 1.60 (95% CI, 1.08–2.39; P = 0.02) to 3.11 (95%CI, 1.02–9.49; P = 0.05).DiscussionInterventions on CS significantly increased CAs’ knowledge of CS, intentions to complete CS, and completions of CS. Physician-led, individual-based, face-to-face client-focused interventions with multiple components should be utilized for CAs.
18F-FSPG PET imaging for the evaluation of indeterminate pulmonary nodules
Authors: Paez Rafael , Shah Chirayu , Cords Angelina J. , Muterspaugh Anel , Helton John E. , Antic Sanja , Eisenberg Rosana , Chen Heidi , Grogan Eric L. , Manning Henry C. , Walker Ronald C. , Massion Pierre P. 
Published: March 2022

Background
18F-fluorodeoxyglucose (FDG) PET/CT is recommended for evaluation of intermediate-risk indeterminate pulmonary nodules (IPNs). While highly sensitive, the specificity of FDG remains suboptimal for differentiating malignant from benign nodules, particularly in areas where fungal lung diseases are prevalent. Thus, a cancer-specific imaging probe is greatly needed. In this study, we tested the hypothesis that a PET radiotracer (S)-4-(3-[18F]-fluoropropyl)-L-glutamic acid (FSPG) improves the diagnostic accuracy of IPNs compared to 18F-FDG PET/CT.

Methods
This study was conducted at a major academic medical center and an affiliated VA medical center. Twenty-six patients with newly discovered IPNs 7-30mm diameter or newly diagnosed lung cancer completed serial PET/CT scans utilizing 18F-FDG and 18F-FSPG, without intervening treatment of the lesion. The scans were independently reviewed by two dual-trained diagnostic radiology and nuclear medicine physicians. Characteristics evaluated included quantitative SUVmax values of the pulmonary nodules and metastases.

Results
A total of 17 out of 26 patients had cancer and 9 had benign lesions. 18F-FSPG was negative in 6 of 9 benign lesions compared to 7 of 9 with 18F-FDG. 18F-FSPG and 18F-FDG were positive in 14 of 17 and 12 of 17 malignant lesions, respectively. 18F-FSPG detected brain and intracardiac metastases missed by 18F-FDG PET in one case, while 18F-FDG detected a metastasis to the kidney missed by 18F-FSPG.

Conclusion
In this pilot study, there was no significant difference in overall diagnostic accuracy between 18F-FSPG and 18F-FDG for the evaluation of IPNs and staging of lung cancer. Additional studies will be needed to determine the clinical utility of this tracer in the management of IPNs and lung cancer.
Epidemiology of atrial fibrillation in the All of Us Research Program
Authors: Alonso Alvaro , Alam Aniqa B. , Kamel Hooman , Subbian Vignesh , Qian Jun , Boerwinkle Eric , Cicek Mine , Clark Cheryl R. , Cohn Elizabeth G. , Gebo Kelly A. , Loperena-Cortes Roxana , Mayo Kelsey R. , Mockrin Stephen , Ohno-Machado Lucila , Schully Sheri D. , Ramirez Andrea H. , Greenland Philip 
Published: March 2022

Background
The prevalence, incidence and risk factors of atrial fibrillation (AF) in a large, geographically and ethnically diverse cohort in the United States have not been fully described.

Methods
We analyzed data from 173,099 participants of the All of Us Research Program recruited in the period 2017–2019, with 92,318 of them having electronic health records (EHR) data available, and 35,483 having completed a medical history survey. Presence of AF at baseline was identified from self-report and EHR records. Incident AF was obtained from EHR. Demographic, anthropometric and clinical risk factors were obtained from questionnaires, baseline physical measurements and EHR.

Results
At enrollment, mean age was 52 years old (range 18–89). Females and males accounted for 61% and 39% respectively. Non-Hispanic Whites accounted for 67% of participants, with non-Hispanic Blacks, non-Hispanic Asians and Hispanics accounting for 26%, 4% and 3% of participants, respectively. Among 92,318 participants with available EHR data, 3,885 (4.2%) had AF at the time of study enrollment, while the corresponding figure among 35,483 with medical history data was 2,084 (5.9%). During a median follow-up of 16 months, 354 new cases of AF were identified among 88,433 eligible participants. Individuals who were older, male, non-Hispanic white, had higher body mass index, or a prior history of heart failure or coronary heart disease had higher prevalence and incidence of AF.

Conclusion
The epidemiology of AF in the All of Us Research Program is similar to that reported in smaller studies with careful phenotyping, highlighting the value of this new resource for the study of AF and, potentially, other cardiovascular diseases.
Pharmacodynamics and Pharmacokinetics of the Potassium-Competitive Acid Blocker Vonoprazan and the Proton Pump Inhibitor Lansoprazole in US Subjects
Authors: Laine Loren , Sharma Prateek , Mulford Darcy J. , Hunt Barbara , Leifke Eckhard , Smith Neila , Howden Colin W. 
Published: March 2022

INTRODUCTION:
We assessed pharmacodynamics and pharmacokinetics of a potassium-competitive acid blocker and proton pump inhibitor in US subjects.

METHODS:
Healthy adults were randomized to 7-day periods of vonoprazan 20 mg once daily followed by lansoprazole 30 mg once daily or the reverse order, separated by ≥ 7 days of washout.

RESULTS:
Vonoprazan (N = 40) had higher proportions of 24-hour periods with intragastric pH > 4 than lansoprazole (N = 41,38) on day 1 (62.4% vs 22.6%, P < 0.0001) and day 7 (87.8% vs 42.3%, P < 0.0001). Separation in pH started ∼2.5 hours after the first dose.

DISCUSSION:
Vonoprazan provided more rapid and potent inhibition of intragastric acidity than lansoprazole in US subjects.
Pentingnya Literasi Budaya di Desa Seni Jurang Blimbing
Authors: Triyono Triyono 
Published: March 2022

Desa Jurang Blimbing teretak di Kelurahan Tembalang, Kota Semarang, Provinsi Jawa Tengah. Di desa ini terdapat beberapa kesenian seperti Ketoprak, Kuda Lumping, dan Kaligrafi. Seiring dengan perkembangan zaman, kesenian-kesenian tersebut harus dilestarikan agar tidak punah dan identitas bangsa tetap terjaga. Pemerintah lewat Kementerian Pendidikan dan Budaya sudah memiliki program literasi budaya yang mendukung tujuan pelestarian tersebut yaitu Gerakan Literasi Nasional. Hal tersebut akhirnya melatarbelakangi penelitian ini untuk mencari tahu sudahkah gerakan literasi budaya dilakukan di desa Jurang Blimbing. Metode yang digunakan adalah penelitian kualitatif, dengan pengambilan data melalui observasi langsung di desa Jurang Blimbing dan wawancara langsung dengan tokoh masyarakat, seniman dan masyarakat umum. Dari penelitian yang dilakukan kemudian didapatkan hasil bahwa seluruh masyarakat di desa Jurang Blimbing tidak mengetahui program pemerintah tersebut. Namun beberapa upaya pelestarian sudah dilakukan dan jika dilihat dengan seksama upaya tersebut merupakan salah satu bentuk dari literasi budaya. Masyarakat desa Jurang Blimbing sudah memiiki kesadaran untuk melestarikan tetapi upaya yang dilakukan kurang maksimal dan tidak tepat sasaran. Dari hasil tersebut, sosialisasi gerakan literasi budaya dari pemerintah sangat dibutuhkan agar masyarakat dapat mengetahui apa yang harus dilakukan untuk lebih mengenal dan melestarikan seni budaya setempat. Selain itu, dukungan dari pustakawan atau pegiat literasi dibutuhkan untuk mendukung keberjalanan program tersebut. Dengan dukungan dan arahan yang telah dilakukan tersebut, diharapkan masyarakat dapat memahami dan berperan aktif dalam pelaksanaan literasi budaya.
Menanamkan Budaya Membaca pada Anak Usia Dini
Authors: Irhandayaningsih Ana 
Published: March 2022

Artikel ini berjudul Menanamkan Budaya Membaca Pada Anak Usia Dini. Di dalam artikel ini terdapat pembahasan mengenai mempersiapkan generasi penerus yang berkualitas dan berwawasan luas dan mencintai buku. menanamkan budaya membaca pada anak usia dini dilakukan di lingkungan pendidikan formal maupun non formal. Pendidikan non formal melalui Taman Penitipan Anak, Kelompok Bermain, dan Pendidikan Anak Usia Dini. Tetapi sebelumnya anak-anak mendapatkan pendidikan di dalam keluarga. Dalam keluargalah anak belajar mengenal lingkungan terdekat, baru kemudian dianjutkan ke TK TPA dan PAUD. Masih terdapat penghambat dalam menanamkan budaya membaca pada anak usia dini, antara lain masih kurangnya kesadaran orang tua untuk selalu mendampingi anaknya dan membimbing anaknya mengenal buku, kurangnya koleksi di TPA di TK maupun di PAUD. Terdapat pembahasan mengenai program untuk mengatasi hal tersebut, yaitu pengadaan koleksi buku bacaan untuk anak usia dini di tempat pendidikan non formal maupun formal. Dalam penulisan artikel ini penulis menggunakan metode deskriptif. Mengamati secara langsung maupun tidak langsung pada anak-anak usia dini yang terdapat di sekitar lingkungan kita. Dari hasil pengamatan tersebut, diketahui bahwa pentingnya membaca untuk anak usia dini, mengingat mereka adalah embrio dari generasi penerus yang akan meneruskan keberlangsungan bangsa. Diharapkan bisa berkelanjutan tdk hanya sekarang tapi juga yang akan datang sehingga kesempatan untuk memiliki generasi penerus yang berkualitas dan berwawasan luas terbuka lebar bagi masyarakat Indonesia.
Peran Pustakawan Sebagai Kreator Konten Digital
Authors: Husna Jazimatul 
Published: March 2022

Penelitian ini membahas perubahan peran pustakawan sebagai perantara informasi karena pengenalan bentuk-bentuk baru dari konten digital yang dibawa oleh teknologi informasi dan komunikasi modern. Fokus utama adalah pada cara di mana perubahan ini telah mempengaruhi tanggung jawab moral pustakawan. peneliti ingin memfokuskan pada Peran Pustakawan Sebagai Kreator Konten Digital, konten yang dimaksud adalah konten digital disebarluaskan di internet melalui media sosial. penelitian ini mengidentifikasi beberapa kecenderungan dalam penciptaan dan penggunaan konten digital dan mengeksplorasi implikasi etis dari tanggung jawab pustakawan dalam merealisasikan tugas tersebut. Untuk mewujudkan peran pustakawan sebagai kreator konten Digital, pustakawan sebaiknya menggunakan langkah baru, dengan melakukan pemiloihan dan pembuatatan akun di media sosial, membuat konten dan melakukan promosi. Dari beberapa apilihan media sosial, pustakawan menggunakan empat media soaial yang paling popular, yaitu istagram, twitter, facebook dan whatsApp. Pendekatan dan metode penelitian kali ini, menggunakan penelitian kualitatif deskriptif, Peneliti mengumpulkan data-data penelitian memalui membaca dan mencatat serta mengolah bahan pustaka.
Strategi Peningkatan Minat Baca Kelompok Tunanetra melalui Media Audiobook (Studi pada SLB-A Bina Insani Bandar Lampung)
Authors: Purnamayanti Arnila , Putri Alviarana Tsamarah Utami 
Published: March 2022

Penggunaan buku audio dianggap lebih efektif karena kelompok tunanetra biasanya lebih fokus dalam hal pendengaran. Media audio dapat memaksimalkan indra yang masih dimiliki oleh orang buta, indera pendengaran. Audiobook merupakan rekaman teks buku atau tulisan lisan dalam bentuk audio yang dapat didengarkan oleh audien dengan isi/substansi sama seperti ketika mereka membaca buku. Audiobook sendiri memiliki banyak manfaat dibandingkan dengan media lainya apalagi sebagai alternative media pembelajaran. Sebagai media pelajaran bagi kelompok tunanetra, dengan menggunakan Audiobook secara tidak langsung dapat menguasai teknologi informasi atau IPTEK. Dengan koleksi bacaan yang lebih variatif sehingga mampu mendorong siswa SLB-A Bina Insani untuk meningkatkan minat baca. Tujuan akhir penulis untuk SLB-A Bina Insani yaitu diharapkan dapat membantu dalam meningkatkan minat baca di SLB-A Bina Insani, dikarenakan jenjang Sekolah Dasar (SD) menjadi titik awal pengembangan kemampuan literasi di pendidikan formal. Di level ini, peserta didik dikenalkan dengan keterampilan literasi dasar yaitu keterampilan mendengarkan, berbicara, membaca dan menulis. Keterampilan ini akan berkembang dengan adanya pembiasaan dan bertujuan untuk menciptakaan SDM yang unggul dan mandiri di era revolusi industri 4.0.
Kontribusi Perpustakaan dalam Mendorong Ratifikasi Traktat Marrakesh Penyandang Disabilitas Netra di Indonesia
Authors: Husna Jazimatul 
Published: March 2022

Di Indonesia banyak penyandang disabilitas yang kesulitan dalam mengakses pendidikan dan pemenuhan atas kebutuhan informasi yang di butuhkan oleh mereka, Salah satunya adalah perpustakaan. Tidak banyak perpustakaan yang ramah dan accessable untuk penyandang disabilitas. Dalam Traktat Marrakesh perpustakaan dapat memberikan kontribusi dan memfasilitasi hak memperoleh informasi dan pendidikan mereka, memfasilitasi kebebasan berekspresi mereka, termasuk kebebasan untuk mencari, menerima dan menyampaikan informasi dan ide-ide dari semua jenis atas dasar kesetaraan dengan orang lain , termasuk melalui semua bentuk komunikasi pilihan mereka.Hal ini dapat dilihat dari minimnya sumber bacaan yang berhuruf Braille, atau dengan format lain seperti audiobook. pada penelitian ini peneliti ingin memfokuskan pada pembahasan Kontribusi Perpustakaan Dalam Mendorong Ratifikasi Traktat Marrakesh Penyandang Disabilitas Netra Di Indonesia, peneliti tertarik mengangkat tema tersebut karena pada poin penting dalam Traktat Marrakesh memberikan izin bagi organisasi dan perpustakaan untuk berbagi koleksi dan judul yang dapat mereka akses dengan komunitas berbahasa lain di seluruh dunia
Card Acceptance by Small Merchants: An Application of the Tourist Test to Peru
Authors: Aurazo Jose , Vega Milton 
Published: March 2022

AbstractThis paper presents a first estimation of the tourist test threshold for interchange fees that makes Peruvian small merchants indifferent between accepting cash and debit cards at the point of sale. We use the tourist test model (initially proposed by Rochet and Tirole), including tax evasion (Aurazo and Vasquez’s model) as an extra factor in the merchants’ decision between cash and card payments. Also, we revisit the existing empirical approaches and propose a new empirical approach, coined as the cash-flow approach, which assumes that small merchants estimate the overall cost in terms of the average ticket related to cash and card payments. Using a Survey on private costs of payment instruments conducted by the Central Reserve Bank of Peru in 2019, our estimates suggest that the tourist test threshold for debit cards is lower than the current interchange fee until 2019, even if tax evasion is not considered. Also, this study helps policymakers to better understand the factors around the merchants’ decision that may be considered to foster digital payments.
Choice of Resistance Used in an Exercise: Simple to Complex Interactions
Authors: Kraemer William J. , Nitka Mike 
Published: March 2022

ABSTRACT
The choice of the resistance used in a workout and its sequence in a training program is a crucial decision for program design. Although the choice in many ways looks simplistic, its interactions with other factors make it a bit more complex when designing a training program. Basic scientific principles help to give context for many aspects of such decisions. Interactions with other acute program variables will also be crucial in how that resistance load in an exercise is manifested in a workout stimulus. Understanding training program sequences using periodization models also affect how one applies the choice of resistances over time. Finally, age and training experience will influence resistance load progressions. Having a handle on these fundamental factors will help give the strength and conditioning professional better insights into the choices made in the resistance used in an exercise.
Resistance Training in Individuals With Hip and Knee Osteoarthritis: A Clinical Commentary With Practical Applications
Authors: Masaracchio Michael , Kirker Kaitlin 
Published: March 2022

ABSTRACT
Osteoarthritis (OA) has been identified as 1 of the 4 most prevalent chronic musculoskeletal conditions, with both prevalence and health care spending rising as the population continues to age. The current US health care system incorporates a model that is driven by individualized one-on-one treatment, which has been successful in the management of certain medical diseases; however, chronic musculoskeletal diseases, such as OA, may be better managed from a population health perspective for more cost-efficient and effective utilization of resources. Although the benefits of resistance training are indisputable, a wide variety of factors (social determinants of health, access to quality care, contextual factors, and comorbidities) may hinder the successful implementation of resistance training programs in older individuals with OA. Considering the complexity and flaws of the health care system, health care professionals involved in movement and exercise should consider innovative models of care that incorporate population health, psychosocial factors, and social determinants of health, in conjunction with individualized treatment of disease, injuries, and pathologies to enhance independence and quality of life in individuals with OA. Therefore, this commentary will discuss innovative strategies to overcome the inherent challenges associated with the implementation of resistance training programs for individuals with hip and knee OA.