bluuebunny/crossref_metadata_2025_split huggingface dataset:
Safety assessment of a new anti-tuberculosis drug in silico and with the participation of healthy volunteers
Authors: Savchenko A. Yu. , Ramenskaya G. V. , Kukes V. G. , Burenkov M. S. , Shilov B. V. 
Published: January 2022

Relevance. In connection with the increase in the number of cases of multidrug-resistant tuberculosis (MDR-TB), the search for new anti-tuberculosis drugs (ATD) is necessary. The assessment of its effect on the human body outside the aspect of the therapeutic effect is one of the main directions in the development of anti-TB drugs.Aim. Evaluation of the possible toxicity of thiosonide, a new domestic anti-TB drug, combining a consistent study of this side of the drug using a bioinformatics approach and an analysis of the results of a clinical safety study.Methods. The bioinformatic assessment was carried out using web services and models to predict the toxicity of thiosonide. The safety assessment in relation to healthy volunteers was carried out as part of a clinical study according to the protocol: «An open-label study of the pharmacokinetics, safety and tolerability of the drug thiozonide, capsule 100 mg with a single dose of increasing doses by various groups of healthy volunteers.» (2013, Permit No. 187 to conduct a clinical trial dated March 22, 2013, issued by the Ministry of Health of the Russian Federation).Results. Potential unwanted targets were identified, the predicted activity value for which was greater than 7. The results obtained indicate the likelihood of the effect of thiosonide on these protein targets and, possibly, the ability of the latter to cause side effects associated with changes in the activity of these molecules. The cytotoxic and carcinogenic effect of thiosonide is not predicted. During a clinical study, the drug thiosonide showed good tolerance and safety, since the identified adverse events did not show a definite or reliable relationship with the study drug. The resolution of all adverse events was complete, and dose escalation did not affect the number, severity of AEs and association with the study drug.Conclusion. The safety analysis of thiosonide demonstrated its good tolerability both during in silico assessment and in a study with the participation of healthy volunteers.
AUTOMATION OF CONSTRUCTION OF A SCHEME FOR SOLVING COMPUTE- INTENSIVE PROBLEMS OF MATHEMATICAL PHYSICS ON SUPERCOMPUTERS
Authors: Глинский Борис Михайлович , Сапетина Анна Федоровна , Снытников Алексей Владимирович , Загорулько Галина Борисовна , Загорулько Юрий Алексеевич , Шестаков Владимир Константинович 
Published: January 2022

В статье представлен подход к разработке информационно-аналитической системы, помогающей исследователю решать вычислительно сложные задачи математической физики на суперкомпьютерах. Система автоматически строит схему решения задачи по спецификации пользователя, введенной им в режиме диалога. Схема включает наиболее подходящие математические модели для решения задачи, численные методы, алгоритмы и параллельные архитектуры, ссылки на доступные фрагменты параллельного кода, которые пользователь может использовать при разработке собственного кода. Построение схемы осуществляется на основе онтологии проблемной области «Решение вычислительно сложных задач математической физики», онтологии заданной предметной области и экспертных правил, построенных с использованием технологии Semantic Web.
The paper presents an approach to the development of an information-analytical system that helps a researcher to solve compute-intensive problems of mathematical physics on supercomputers. The system automatically builds a scheme for solving the problem according to the user's specification entered by him in the dialogue mode. The scheme includes the most suitable mathematical models for solving the problem, numerical methods, algorithms and parallel architectures, links to available fragments of parallel code that the user can use when developing their own code. The construction of the scheme is carried out on the basis of the ontology of the problem area "Solving compute-intensive problems of mathematical physics", the ontology of a given subject area and expert rules built using the Semantic Web technology.
PARAMETERS MONITORING ORGANIZATION OF THE SOLAR PANELS EXPERIMENTAL STAND
Authors: Иванов Роман Андреевич , Максаков Никита Владимирович 
Published: January 2022

Актуальность разработки обусловлена необходимостью создания устройства для сбора и обработки информации с экспериментального стенда солнечных панелей. Назначением стенда является получение достоверных данных для верификации моделей оценки показателей гелиопотенциала, использующихся при обосновании эффективности применения солнечных электростанций на территории восточных регионов России. Дано описание основного и вспомогательного оборудования экспериментального стенда. Солнечные панели стенда разноориентированы для определения наиболее эффективного угля наклона и обоснования необходимости применения следящей за солнцем системы. Для снятия и записи мгновенной мощности солнечных панелей разработано устройство на основе микроконтроллера Arduino. Для мониторинга показаний силы тока используется шунтовый амперметр, подключаемый в разрыв цепи питания. Приведена схема счётчика тока и описана его работа. Приведены первичные результаты собранных данных. Намечены основные этапы дальнейшей обработки данных.
The relevance of the presented development is due to the need to create a device to read and process information from an experimental array of solar panels. The purpose of the array is to obtain reliable data for the verification of models for estimating photovoltaic power potential indicators used in justifying the feasibility of the adoption of solar power plants in the eastern regions of Russia. We present a description of the main and auxiliary equipment of the experimental array. The array's solar panels are arranged in different ways so as to determine the most efficient tilt angle and justify the need to use a sun tracking system. The proprietary device based on the Arduino microcontroller was designed to read and write the value of instantaneous power of solar panels. To monitor the readings of the amperage, a shunt ammeter is used, which is connected to the gap of the power circuit. The study provides a diagram of the current meter and describe its operation. We outlined the main stages of subsequent data processing.
REENGINEERING TECHNIQUE ADAPTATION OF LEGACY SOFTWARE SYSTEMS
Authors: Массель Алексей Геннадьевич , Мамедов Тимур Габилович 
Published: January 2022

В статье рассматривается адаптация методики реинжиниринга унаследованных систем. Приводится обзор подходов к реинжинирингу. Несмотря на то, что термин «реинжиниринг» в первую очередь относится к изменению бизнес процессов, он удачно подходит и к модернизации программного обеспечения. Обосновывается необходимость адаптации методики. В статье описывается применение адаптированной методики на примере реинжиниринга программного комплекса для прогнозных исследований ТЭК. Приведен исторический обзор версий ПК «ИНТЭК» и описаны поэтапно все шаги проведения его реинжиниринга на основе агентно-сервисного подхода
The article presents an adaptation of the legacy systems reengineering technique. An overview of approaches to reengineering is given. Although the term “reengineering” primarily refers to changing business processes, it is well suited to software development. The necessity of adapting the method has been substantiated. The article describes the application of the described methodology on the example of software complex reengineering for predictive research of the fuel and energy complex. A historical overview of the current problem is given and all stages of INTEC PC reengineering are described step by step
Un gouverneur de province et l’imprimé : César de Vendôme et les troubles de 1614 en Bretagne
Authors: Rivault Antoine 
Published: January 2022

Au printemps 1614, les grands princes de France entrent en conflit ouvert avec la régente Marie de Médicis et quittent la cour. Récemment émancipé, César de Vendôme, fils naturel et légitimé d’Henri IV, se réfugie en Bretagne, province dont il est le gouverneur depuis 1598. Pour justifier et légitimer sa conduite, il fait imprimer quatre de ses lettres missives adressées au roi son frère et à la reine régente. Ces courts textes interrogent une nouvelle manière d’exercer le pouvoir pour les gouverneurs de province. Ces derniers déploient dans leurs textes imprimés un langage politique précis et un discours de l’obéissance qui ne sont pas uniquement des témoignages d’une « duplicité rhétorique ». Pourtant, la stratégie discursive du duc de Vendôme s’avère des plus fragiles auprès de la famille royale comme des gentilshommes bretons, qui se divisent profondément sur la fidélité qu’ils lui doivent, et ce, tout juste avant la réunion des États généraux à Paris.
Factors Affecting Non-Performing Loan in Sri Lanka: A Qualitative Study
Authors: Keshani A. L. A. D. , Jayatilake L. V. K. 
Published: January 2022

Purpose: Comparison of NBFC’s Non-Performing loan Ratio was given a research problem to the researcher to argue that which factors will be affected to the NPL of high risky non-banking financial company of Sri Lanka as the case study. This study examines the factors affecting non-performing loans of ABC Financed Limited. The objectives were to identify the Institutional relating Factors, Customer relating factors and Remedial Mechanisms of Dealing with Non-Performing Loans. Methodology: The scope of the research was limited to ten (10) Employees of ABC Finance Limited and ten (10) Customers of ABC Financed Limited. The study adopted the general qualitative research methodology using Interpretivism paradigm, Case study strategy and Grounded Theory Approach and in-depth interviews were conducted in order to collect data, and all the interviews were recorded, transcribed and coded. Open coding, selective coding and Axial coding were done in order to get the final framework. Findings: The findings revealed, Customer relating factors also reflect in case of nonperforming loans and there are some new factors were also found as Institutional related factors. Some moderate mechanisms also found to implement for all the financial companies and Banks. Originality / Value: The study contributes to expanding existing literature by investigating the issues of value relevance of financial statements within the Sri Lankan context, incorporating both red flags and accrual components.
Effective Barriers: The Role of NKT Cells and Innate Lymphoid Cells in the Gut
Authors: Cairo Cristiana , Webb Tonya J 
Published: January 2022

Abstract
The critical role of commensal microbiota in regulating the host immune response has been established. In addition, it is known that host–microbial interactions are bidirectional, and this interplay is tightly regulated to prevent chronic inflammatory disease. Although many studies have focused on the role of classic T cell subsets, unconventional lymphocytes such as NKT cells and innate lymphoid cells also contribute to the regulation of homeostasis at mucosal surfaces and influence the composition of the intestinal microbiota. In this review, we discuss the mechanisms involved in the cross-regulation between NKT cells, innate lymphoid cells, and the gut microbiota. Moreover, we highlight how disruptions in homeostasis can lead to immune-mediated disorders.
Metabolic Sex Dimorphism of the Brain at the Gene, Cell, and Tissue Level
Authors: Lee Jun Won , Profant Martin , Wang Chao 
Published: January 2022

Abstract
The palpable observation in the sex bias of disease prevalence in the CNS has fascinated scientists for several generations. Brain sex dimorphism has been visualized by imaging and analytical tools at the tissue, cellular, and molecular levels. Recent work highlighted the specificity of such sex bias in the brain and its subregions, offering a unique lens through which disease pathogenesis can be investigated. The brain is the largest consumer of energy in the body and provides a unique metabolic environment for diverse lineages of cells. Immune cells are increasingly recognized as an integral part of brain physiology, and their function depends on metabolic homeostasis. This review focuses on metabolic sex dimorphism in brain tissue, resident, and infiltrating immune cells. In this context, we highlight the relevance of recent advances in metabolomics and RNA sequencing technologies at the single cell resolution and the development of novel computational approaches.
Features of B Cell Responses Relevant to Allergic Disease
Authors: Allen Christopher D C 
Published: January 2022

Abstract
This Brief Review delves into B cell responses in the context of allergy. The primary contribution of B cells to allergy is the production of IgE, the Ab isotype that triggers immediate hypersensitivity reactions through the release of mediators from mast cells and basophils. B cells may also have protective roles in allergy, such as through the production of IgG or as regulatory B cells. In this review, I focus on the basic principles of B cell differentiation and discuss features relevant to allergic immune responses. In particular, I discuss: (1) class-switch recombination; (2) plasma cell differentiation; (3) germinal centers and affinity maturation; and (4) memory B cells and recall responses, with an emphasis on IgE, IgG1, and IgG4. I also consider how B cells may contribute to allergic responses independent of Ab production—for example, by serving as APCs.
Efficacy of Core Needle Biopsy in the Diagnosis of Pediatric Extracranial Solid Malignancies
Authors: Loganathan Arun Kumar , Jacob Tarun John , Matthew Leni Grane , Moses Vinu , Keshava Shyam Kumar Nidugala , Priscilla Anne Jennifer , Kurian Jujju Jacob 
Published: January 2022

Introduction:
Core needle biopsies of solid masses in children are a minimally invasive technique. It guides to a definitive diagnosis and facilitates management.

Aims and Objectives:
To determine the accuracy, sensitivity, and specificity of core needle biopsies in diagnosing pediatric solid masses.

Materials and Methods:
A retrospective analysis of 430 children, who underwent core needle biopsy for solid masses between January 2007 and December 2016 at CMC Vellore, was done.

Results:
Retroperitoneal and intra-abdominal masses constituted 66% of cases. Real-time image guidance was used in 44% of cases. An accurate diagnosis was obtained in 93.6% of cases, while results did not correlate with the final diagnosis in 3.4%. Three percent had inadequate or necrotic tissue. None of the children had postprocedure complications.

Conclusion:
Core needle biopsies serve as good diagnostic modality, with minimal risks, in making a conclusive diagnosis and deciding on the line of management.
Laparoscopic Cystogastrostomy in Children with Pancreatic Pseudocysts
Authors: Gaikwad Vivek Samuel , Kisku Sundeep M. C. , Kurian Jujju Jacob , Jacob Tarun John K , Mathai John 
Published: January 2022

Introduction:
Pancreatic pseudocysts (PPCs) and walled-off necrosis (WON) in children following acute pancreatitis are uncommon. The various modalities of therapy possible are conservative treatment, external drainage, endoscopic stenting, and internal surgical drainage procedures. There are no existing guidelines for the management of PPC in children. We evaluate the outcomes of laparoscopic cystogastrostomy (LCG) performed at our center.

Materials and Methods:
Eight children (median age: 10 years) underwent LCG for large PPC (median size: 12.5 cm). There were seven patients with PPC and one with WON. Seven underwent LCG by a transgastric approach and one underwent LCG by a retrogastric approach.

Results:
Seven out of the eight patients had complete resolution of symptoms and the PPC. The median follow-up period was 32 months (interquartile range: 9.5–55.5 months). There were no conversions. There was one patient with a WON who developed a recurrence.

Conclusion:
LCG is a safe and effective treatment option for large PPC/WON in children. A posterior retrogastric approach, when indicated, is a safe approach with a comparable outcome.
Clinical profile of patients with endophthalmitis
Authors: Almarzouki N , Alessa S , Raffa L 
Published: January 2022

ABSTRACT

Aim:
This study aimed to profile the clinical features and demographics of patients with endophthalmitis in a tertiary care center, Western region, Saudi Arabia. We used a retrospective cross-sectional case series at King Abdulaziz University Hospital.

Materials and Methods:
Endophthalmitis was diagnosed in a total of 14 eyes of 14 patients treated in our hospital between 2002 and 2018. The patients' medical records were reviewed to gather demographic and clinical data.

Results:
The mean age of patients was 52.8 ± 19.2 years, and 50% of patients were male. The majority of endophthalmitis cases were post-ophthalmic surgery (50%), 35.7% were of endogenous origin, 7.2% were associated with corneal ulcer with perforation, and 7.2% were post open globe injury. Patients' admission to the hospital ranged from 2 to 10 days from symptoms occurrence with a median of 5 days. Half of the patients presented with no light perception vision, counting fingers in 14.2%, hand motion in 14.2%, light perception in 7.2%, and 20/300 in 7.2%. The final visual outcome improved in four cases (28.5%) with best corrected visual acuity of 20/40 reached in one patient.

Conclusion:
Post- ophthalmic surgery and endogenous endophthalmitis were the most common causes of endophthalmitis among our patients, with late presentation to the hospital and poor vision at presentation also being common findings. These findings highlight the necessity of proper patient education, after care and adherence to sterile techniques in ensuring that patients recover successfully from ophthalmic surgery.
SOSIALISASI DAN PELATIHAN PENGGUNAAN MESIN CETAK DIGITAL PRINTING SEBAGAI PENUNJANG KETERAMPILAN HARD SKILL BAGI SISWA SMK PERGURUAN LAKSAMANA MARTADINATA MEDAN
Authors: Juwairiah Juwairiah 
Published: January 2022

Pelatihan dalam rangka kegiatan Pengabdian Pada Masyarakat ini bertujuan untuk memberikan bekal ilmu pengetahuan dan teknologi tentang bagaimana menggunakan mesin cetak digital printing. Mesin cetak yang digunakan adalah mesin cetak digital printing Fuji Xerox produksi Jepang. Peserta pelatihan merupakan siswa SMK Perguruan Laksamana Martadinata Medan. Pelaksanaan diawali dengan memberi materi sampai ke proses cetak . Materi diakhiri dengan memberikan tugas bagi masing-masing peserta untuk mencetak brosur secara mandiri. Dikarenakan PPKM darurat 4 di Kota Medan maka pihak sekolah hanya mengizinkan 5 orang siswa untuk mengikuti pelatihan tersebut. Dari peserta dengan jumlah 5 orang siswa, semuanya dapat mengikuti pelatihan dari awal sampai akhir yaitu dapat menyelesaikan tugas mandiri dengan baik, mampu mencetak brosur yang berkualitas. Metode yang digunakan dalam pelatihan ini antara lain metode demonstrasi yaitu peserta secara langsung praktek sesuai dengan keadaan yang sebenarnya mencetak brosur menggunakan mesin digital printing, program yang digunakan yaitu program Fiery 1,. Metode evaluasi dengan melihat perbedaan kualitas cetakan sebelum dan sesudah pelatihan. Hasilnya berupa keterampilan hardskill mencetak brosur dengan mesin digital printing yang sesuai dengan standar cetak brosur yaitu hasil cetak yang presisi.
PELATIHAN SURVEI KEPUASAN PELANGGAN UNTUK WIRAUSAHA MUDA
Authors: Ridwan Muhamad 
Published: January 2022

Tingginya angka pengangguran muda yang mencapai 43,4 persen menjadi titik tolak Rumah Siap Kerja sebagai pusat pelayanan terpadu untuk kegiatan pelatihan keterampilan kerja dan kewirausahaan. Dalam hal membekali para pencari kerja dengan kemampuan untuk berwirausaha dan dapat mengelola usahanya dengan baik. Pengabdi berinisiatif memberikan pelatihan survei kepuasan pelanggan. Dalam kegiatan pelatihan ini, para wirausaha muda ataupun calon wirausaha diberi materi kemampuan membuat survei kepuasan pelanggan secara mandiri. Dengan diadakannya pelatihan ini diharapkan seorang wirausaha dapat dengan tepat mengidentifikasikan apa yang dibutuhkan dan diinginkan oleh pelanggannya dan berupaya memperkecil perbedaan (gap) apa yang diinginkan dan produk yang dihasilkan dengan apa yang sebenarnya pelanggan terima.
Energy balance formation of sub-eutectoide fayalita at high pressures in particle separators
Authors: Echegaray Alberto 
Published: January 2022

This article presents an approach to the problem of ceramic types adhesion, applying energy and matter balance to the established control volume (cyclone) with the use of mathematical formulas that are interrelated to develop mathematical calculations and establish a new mathematical model The first results are obtained by operating the energy balance considering the collision of particles, using the principle of conservation of energy, the first law of thermodynamics, in order to obtain information that allows describing the phenomena of thermoplasticity and creep, in the formation of adhesions, from a physicochemical and kinetic point of view, which will serve as the basis for understanding their effect. As a result, an energy value of 660 kJ / mol was obtained, sufficient energy to start the transformation of the solid particles to a state of thermo-flow that allows the adhesion phenomenon to be started.
Keywords: Adhesion, energy balance, cyclones, elutriation, eutectoid, fayalite, thermoplasticity.
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