bluuebunny/crossref_metadata_2025_split huggingface dataset:
Neural dynamics and coupling underlying uncertain anticipatory conflicts in anxious individuals
Authors: Han Shangfeng , Hu Jie , Gao Jie , Fan Jiayu , Xu Xinyun , Xu Pengfei , Luo Yue-jia 
Published: January 2022

Abstract
Anticipation plays an important role in cognitive control and related psychiatric disorders such as anxiety. However, anticipation processing of conflicts in anxious individuals and the underlying brain mechanisms remain unknown. Using a newly designed cue-flanker task, we observed faster responses to congruent flankers with certain cues in individuals with high trait anxiety (HTA) than those with low trait anxiety (LTA). Microstate analyses revealed less occurrence of cue-evoked microstates in HTA than LTA. Importantly, the less occurrence of specific state was correlated to the larger flanker effect in HTA, suggesting that deficient conflict control in anxiety is associated with abnormal vigilance-related dynamic processing during anticipation. Delta–beta coupling at anticipation stage mediated the association between the level of anxiety and reaction time in conflict processing with uncertain cues in HTA, suggesting the mediatory role of delta–beta coupling in anticipatory conflict processing of anxious individuals. These results suggest hyperactive anticipatory processing of goal-relevant information for the upcoming conflict in anxious individuals. Our findings provide neurocognitive evidence for altered anticipatory cognitive control in anxious individuals and have important implications for diagnosis and treatment of anxiety-related disorders.
Trend in Sensitivity of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Serology One Year After Mild and Asymptomatic Coronavirus Disease 2019 (COVID-19): Unpacking Potential Bias in Seroprevalence Studies
Authors: Bailie Christopher R , Tseng Yeu Yang , Carolan Louise , Kirk Martyn D , Nicholson Suellen , Fox Annette , Sullivan Sheena G 
Published: January 2022

Abstract
A key aim of serosurveillance during the coronavirus disease 2019 (COVID-19) pandemic has been to estimate the prevalence of prior infection, by correcting crude seroprevalence against estimated test performance for polymerase chain reaction (PCR)-confirmed COVID-19. We show that poor generalizability of sensitivity estimates to some target populations may lead to substantial underestimation of case numbers.
Timing of the pre-transplant workup for renal transplantation: is there room for improvement?
Authors: Dirix Marie , Philipse Ester , Vleut Rowena , Hartman Vera , Bracke Bart , Chapelle Thierry , Roeyen Geert , Ysebaert Dirk , Van Beeumen Gerda , Snelders Erik , Massart Annick , Leyssens Katrien , Couttenye Marie M , Abramowicz Daniel , Hellemans Rachel 
Published: January 2022

Abstract

Background
Since patient survival after kidney transplantation is significantly improved with a shorter time on dialysis, it is recommended to start the transplant workup in a timely fashion.

Methods
This retrospective study analyses the chronology of actions taken during the care for patients with chronic kidney disease (CKD) stage 5 who were waitlisted for a first kidney transplant at the Antwerp University Hospital between 2016 and 2019. We aimed to identify risk factors for a delayed start of the transplant workup (i.e. after dialysis initiation) and factors that prolong its duration.

Results
Of the 161 patients included, only 43% started the transplant workup before starting dialysis. We identified the number of hospitalization days {odds ratio [OR] 0.79 [95% confidence interval (CI) 0.69–0.89]; P &lt; 0.001}, language barriers [OR 0.20 (95% CI 0.06–0.61); P = 0.005] and a shorter nephrology follow-up before CKD stage 5 [OR 0.99 (95% CI 1.0–0.98); P = 0.034] as factors having a significant negative impact on the probability of starting the transplant screening before dialysis. The workup took a median of 8.6 months (interquartile range 5–14) to complete. The number of hospitalization days significantly prolonged its duration.

Conclusion
The transplant workup was often started too late and the time needed to complete it was surprisingly long. By starting the transplant workup in a timely fashion and reducing the time spent on the screening examinations, we should be able to register patients on the waiting list before or at least at the start of dialysis. We believe that such an internal audit could be of value for every transplant centre.
Dual atrial rhythms: a case report of an unusual cause of pacemaker syndrome
Authors: Sirinvaravong Natee , Heimann Mark , Liskov Steve , Yan Gan-Xin 
Published: January 2022

Abstract

Background
Atrial dissociation (AD) is described as the existence of two simultaneous electrically isolated atrial rhythms. Theoretically, detection of dual atrial rhythms with a sufficiently high rate by pacemaker can lead to automatic mode switching and associated pacemaker syndrome. Such a clinical observation has not been reported before in the literature.

Case summary
An 87-year-old female with Ebstein’s anomaly status post-tricuspid valve annuloplasty and tricuspid valve replacement and a dual-chamber pacemaker presented with congestive heart failure 1 week after undergoing atrial lead revision. Interrogation of her dual-chamber pacemaker revealed two atrial rhythms: sinus or atrial-paced rhythm and electrically isolated atrial tachycardia (AT). Sensing of both atrial rhythms by the pacemaker led to automatic mode switching, which manifested as ventricular paced rhythm with retrograde P waves on electrocardiogram. Adjusting the atrial lead sensitivity to a level higher than the sensing amplitude of AT restored atrial paced and ventricular sensed rhythm, which resulted in resolution of heart failure symptoms.

Discussion
Regardless of the cause of AD, there must be electrical insulation between the two rhythms for their independent coexistence in the atria. Atrial dissociation can lead to pacemaker syndrome from automatic mode switching. If the sensing amplitude during sinus rhythm is significantly larger than that of AT, adjusting the atrial lead sensitivity would solve the issue, as in the present case. Otherwise, atrial lead revision, pharmacotherapy, or AT ablation should be considered.
Mechanical ventilation during cardiopulmonary bypass in neonates improves postoperative outcome
Authors: Rodríguez-Lima Marta Macarena , González-Calle Antonio , Adsuar-Gómez Alejandro , Sánchez-Martín María José , Sepúlveda Iturzaeta Álvaro , Sánchez-Valderrábanos Elia , García-Hernández Juan Antonio , Murillo-Pozo María Ángeles , Ordóñez-Fernández Antonio , Hosseinpour Amir-Reza 
Published: January 2022

Abstract

OBJECTIVES
Cardiopulmonary bypass generates a systemic inflammatory response. This inflammatory response is reduced if patients are ventilated during bypass, as evidenced by lower levels of postoperative circulating inflammatory mediators. However, this does not appear to make much clinical difference in adults, at least not consistently, but, to our knowledge, has never been assessed in paediatric cardiac surgery, which is the objective of this study.

METHODS
This is a prospective clinical study of 12 consecutive neonates operated for the correction of either transposition of the great arteries ± ventricular septal defect or aortic arch hypoplasia ± ventricular septal defect, who were ventilated during cardiopulmonary bypass. These were compared to 11 neonates with the same malformations, who had undergone the same operations but without being ventilated during bypass (historical control group).

RESULTS
One patient from the control group died on the 15th postoperative day due to sepsis and multi-organ failure. Bypass times and cross-clamp times were similar in the 2 groups. Ventilation on bypass was associated with significantly lower postoperative serum concentrations of C-reactive protein, shorter mechanical ventilation and lower vasoactive-inotropic score. Duration of stay on intensive care unit (ICU) showed a tendency to be shorter in patients who were ventilated on bypass, but this did not reach statistical significance. There were no differences between the 2 groups with respect to postoperative mixed venous oxygen saturations and serum concentrations of lactate and troponin I.

CONCLUSIONS
Mechanical ventilation during cardiopulmonary bypass in neonates improves postoperative outcome.
Fitness Effects of Mutations: An Assessment of PROVEAN Predictions Using Mutation Accumulation Data
Authors: Sandell Linnea , Sharp Nathaniel P 
Published: January 2022

Abstract
Predicting fitness in natural populations is a major challenge in biology. It may be possible to leverage fast-accumulating genomic data sets to infer the fitness effects of mutant alleles, allowing evolutionary questions to be addressed in any organism. In this paper, we investigate the utility of one such tool, called PROVEAN. This program compares a query sequence with existing data to provide an alignment-based score for any protein variant, with scores categorized as neutral or deleterious based on a pre-set threshold. PROVEAN has been used widely in evolutionary studies, for example, to estimate mutation load in natural populations, but has not been formally tested as a predictor of aggregate mutational effects on fitness. Using three large published data sets on the genome sequences of laboratory mutation accumulation lines, we assessed how well PROVEAN predicted the actual fitness patterns observed, relative to other metrics. In most cases, we find that a simple count of the total number of mutant proteins is a better predictor of fitness than the number of proteins with variants scored as deleterious by PROVEAN. We also find that the sum of all mutant protein scores explains variation in fitness better than the number of mutant proteins in one of the data sets. We discuss the implications of these results for studies of populations in the wild.
Association Between Baseline Buccal Telomere Length and Progression of Kidney Function: The Health and Retirement Study
Authors: Westbrook Adrianna , Zhang Ruiyuan , Shi Mengyao , Razavi Alexander C , Huang Zhijie , Chen Jing , He Jiang , Kelly Tanika , Shen Ye , Li Changwei 
Published: January 2022

Abstract
We aimed to evaluate associations of baseline telomere length with overall and annual change in estimated glomerular filtration rate (eGFR) and trajectory of kidney function during an 8-year follow-up. A total of 3 964 participants of the Health and Retirement Study were included. We identified 3 trajectory groups of kidney function: consistently normal (n = 1 163 or 29.3%), normal to impaired (n = 2 306 or 58.2%), and consistently impaired groups (n = 495 or 12.5%). After controlling for age, sex, race, education, smoking, drinking, diabetes, heart disease, blood pressure, body mass index, total cholesterol, and hemoglobin A1c, participants with longer telomere length were 20% less likely (odds ratio = 0.80, 95% confidence interval: 0.69–0.93, p = .003) to have a normal to impaired kidney function trajectory than a consistently normal function trajectory. Telomere length was not associated with changing rate of eGFR over 8 years (p = .45). Participants with longer telomere length were more likely to have consistently normal kidney function.
A chromosome-scale genome assembly for the holly (Ilex polyneura) provides insights into genomic adaptations to elevation in Southwest China
Authors: Yao Xin , Lu Zhiqiang , Song Yu , Hu Xiaodi , Corlett Richard T 
Published: January 2022

AbstractSouthwest China is a plant diversity hotspot. The near-cosmopolitan genus Ilex (c. 664 spp., Aquifoliaceae) reaches its maximum diversity in this region, with many narrow-range and a few widespread species. Divergent selection on widespread species leads to local adaptation, with consequences for both conservation and utilization, but is counteracted by geneflow. Many Ilex species are utilized as teas, medicines, ornamentals, honey plants, and timber, but variation below the species level is largely uninvestigated. We therefore studied the widespread Ilex polyneura, which occupies most of the elevational range available and is cultivated for its decorative leafless branches with persistent red fruits. We assembled a chromosome-scale genome using approximately 100x whole genome long-read and short-read sequencing combined with Hi-C sequencing. The genome is approximately 727.1 Mb, with a contig N50 size of 5 124 369 bp and a scaffold N50 size of 36 593 620 bp, for which the BUSCO score was 97.6%, and 98.9% of the assembly was anchored to 20 pseudochromosomes. Out of 32 838 genes predicted, 96.9% were assigned functions. Two whole genome duplication events were identified. Using this genome as a reference, we conducted a population genomics study of 112 individuals from 21 populations across the elevation range using restriction site-associated DNA sequencing (RADseq). Most populations clustered into four clades separated by distance and elevation. Selective sweep analyses identified 34 candidate genes potentially under selection at different elevations, with functions related to responses to abiotic and biotic stresses. This first high-quality genome in the Aquifoliales will facilitate the further domestication of the genus.
Radical Right Populism and the Politics of Cruelty: The Case of COVID-19 in Brazil Under President Bolsonaro
Authors: Farias Deborah Barros Leal , Casarões Guilherme , Magalhães David 
Published: January 2022

Abstract
In this article, we explore cruelty under populism, focusing on radical right populism. We develop our argument by introducing a two-dimensional model of cruel behavior in politics, in which cruelty is conceptualized as a dependent variable defined in terms of empathy (how the leader addresses those who suffer) and action (how the leader acts to alleviate suffering). This framework provides a nuanced understanding of how cruelty and populism connect, providing an original and cutting-edge contribution to both bodies of work. We use our two-dimensional model of cruel behavior to shed light on the different ways radical right populists (RRP) embrace cruelty as part of their political strategies. We have come to three “ideal” types of RRP cruel behavior: downplaying, blaming, and conspiring. In order to advance our ideas, we rely on the qualitative analysis of Brazil's far-right populist President Jair Bolsonaro and his (in)actions regarding COVID-19, who once asked about the soaring number of dead from COVID-19 simply answered: “So what? What do you want me to do?.” Using this case study, we empirically illustrate different ways in which how cruelty can manifest itself in practice and what real-life consequences it can have.
The Costs of Legitimacy for Political Institutions
Authors: Agné Hans , Söderbaum Fredrik 
Published: January 2022

AbstractCan political institutions be too legitimate for their own good? The standard view of legitimacy treats it purely as a resource—political institutions that enjoy legitimacy can draw on voluntary cooperation among their subjects to reach their aims, which is believed to make them more effective than institutions that lack legitimacy and must instead use coercion or bribery to reach aims. We challenge this conventional wisdom by advancing a more general theory that is sensitive also to the costs of legitimacy. High levels of legitimacy, we suggest, can make political actors complacent about the status quo and cause them to pay insufficient attention to problems related to implementation. In contrast, low levels of legitimacy—or legitimacy crises—can serve as a wake-up call and motivate actors to work harder to reach their original or wider goals. We illustrate this theory through a case study of the African Union, assessing when and how legitimacy serves as a cost or as a resource for political institutions, with implications for decision-making, implementation, and effectiveness.
Novel non-cytotoxic antimicrobial peptides WSKK11 and WSRR11 with potent activity against Cutibacterium acnes
Authors: Theansungnoen Tinnakorn , Phosri Santi , Bumrungthai Sureewan , Daduang Jureerut , Klaynongsruang Sompong , Daduang Sakda 
Published: January 2022

Abstract

Objectives
Cutibacterium acnes is one of the common multifactorial causes that play an important role in the pathophysiology of acne vulgaris. We aimed to develop novel antimicrobial peptides for reduction of the hypercolonization.

Methods
Six cationic peptides were derived by de novo designation. The antimicrobial and cytotoxic activities of peptides were investigated. The peptide conformation was determined by circular dichroism spectrometry. The antimicrobial effects of peptides were evaluated using scanning electron microscopy (SEM), transmission electron microscopy (TEM) and DNA-binding ability assay.

Results
Among designed peptides, WSKK11 and WSRR11 were effective antimicrobials against C. acnes at MICs of 128 and 64 mg/L, respectively. The MICs of WSKK11 against Staphylococcus epidermidis, Staphylococcus aureus and Candida albicans were 8, 8 and 32 mg/L, while those of WSRR11 were 64, 32 and 32 mg/L, respectively. WSKK11 and WSRR11 were less toxic to human erythrocytes (&lt;2%) and not toxic to macrophages, keratinocytes and fibroblasts up to 512 mg/L. WSKK11 and WSRR11 mostly revealed the conformation of the undefined or random coil structures under mimicked environmental conditions. The peptides affected cell surfaces and cell membranes of C. acnes as well as possibly translocating through the cell membrane, observed by a combination of SEM and TEM, respectively. WSKK11 and WSRR11 had the ability to bind bacterial DNA.

Conclusions
The two novel antimicrobial peptides WSKK11 and WSRR11 are members of a new class of antimicrobial agents that could deal with acne problems. Therefore, the antimicrobial peptides may be promising novel active agents for dermatological, beauty and cosmeceutical applications.
The Use of Fact-Finding within the Human Rights Council: Shaping Perceptions
Authors: de Vries Barry 
Published: January 2022

AbstractFact-finding has become increasingly important in the field of human rights. This has led to a proliferation of fact-finding mechanisms created by the Human Rights Council. Through the creation of a mandate there is significant political influence in the subject matter that a fact-finding commission can actually investigate. This article assesses to what extent the choices made in the creation of the mandates of fact-finding commissions are discussed and how these choices influence the outcomes of commissions and help shape the narrative. It puts the mandates of fact-finding commissions in the context of the political perception of the situation at the time of the creation of the mandate, the resulting report. This will show how the mandates of fact-finding missions are influenced by political considerations and how these considerations influence the reception of their outcomes.
Percutaneous CT-guided resection of acetabular osteoid osteoma: a case report
Authors: Arriaza Carlos R , Salguero Edgar Javier , Cobar Bustamante Andres 
Published: January 2022

Abstract
Osteoid osteoma located on the hip joint presents with atypical symptoms that can be misdiagnosed or missed. Multiple image studies can be made for diagnosis but OO should be suspected to properly choose the right one. Percutaneous resection with CT guidance is a reproducible and accurate technique with the appropriate tools and a specialist team to obtain optimal results.
Internal borders as a source of linguistic divergence: A multi-method dialectometric approach
Authors: Valls Esteve 
Published: January 2022

AbstractFollowing the realization that the north-western dialect continuum of Catalan is splitting along the political border between Catalonia and Aragon, in Spain, this article upholds the view that internal borders should be incorporated into border studies, since they often trigger processes of linguistic convergence and divergence which alter the most common patterns of linguistic diffusion. The language change is analysed in apparent time using a combination of dialectometric techniques that constitute an innovation within the field of border effects, and which, in the specific case of Catalan in Aragon, illustrates the usefulness of dialectometry in detecting processes of structural hybridization in areas where the vitality of the language is most seriously undermined. Lastly, this article evinces the need to further develop a form of social dialectometry that not only answers sociolinguistic questions, but also makes it possible to objectively evaluate the social motivations fuelling the ongoing changes.
Independent Evaluation of Two Prototype Immunochromatographic Tests for Dengue Fever Developed by InBios
Authors: Chen Hua-Wei , Maldonado Tania D , Lee Cheng-Rei , Williams Maya , Defang Gabriel N , Ellison Damon W , Van De Wyngaerde Marshall , Rooney Calli M , Wu Shuenn-Jue L 
Published: January 2022

ABSTRACT

Introduction
Dengue fever, caused by any of the four dengue viruses (DENV1–4), is endemic in more than 100 countries around the world. Each year, up to 400 million people get infected with dengue virus. It is one of the most important arthropod-borne viral diseases. Dengue’s global presence poses a medical threat to deploying military personnel and their dependents. An accurate diagnosis followed by attentive supportive care can improve outcomes in patients with severe dengue disease. Dengue diagnostic tests based on PCR and ELISA platforms have been developed and cleared by the U.S. FDA. However, these diagnostic assays are laborious and usually require highly trained personnel and specialized equipment, which presents a significant challenge when conducting operations in austere and resource-constrained areas. InBios International, Inc. (Seattle, WA) has developed two rapid and instrument-free immunochromatographic test prototype devices (multiplex and traditional formats) for dengue diagnosis.

Materials and Methods
To determine the performance of the InBios immunochromatographic tests, 183 clinical samples were tested on both prototype devices. Both assays were performed without any instruments and the results were read in 20 minutes.

Results
The traditional format had better overall performance (sensitivity: 97.4%; specificity: 90%) than the multiplex format (sensitivity: 86.9%; specificity: 63.3%). The traditional format was superior in serotype-specific detection with 100% overall sensitivity for DENV1, DENV3, and DENV4 and 93.3% sensitivity for DENV2 compared to the multiplex format (91.7%, 78.3%, 83.3%, and 96.3% for DENV1, 2, 3, and 4, respectively). The traditional format was easier to read than the multiplex format. The multiplex format was simpler and faster to set up than the traditional format.

Conclusions
The InBios traditional format had a better overall performance and readability profile than the multiplex format, while the multiplex format was easier to set up. Both formats were highly sensitive and specific, were easy to perform, and did not require sophisticated equipment. They are ideal for use in resource-limited settings where dengue is endemic. Based on our overall assessment, the traditional format should be considered for further development and used in the upcoming multicenter clinical trial toward FDA clearance.