bluuebunny/crossref_metadata_2025_split huggingface dataset:
Laparoscopic mesh placement during inguinal hernia repair: a meta‐analysis of two methods of repair
Authors: Demetriou George , Ahmad Muhammad S. , Robinson Steven J. 
Published: October 2022

AbstractBackgroundThere are several modifications in the technique for the placement of mesh during laparoscopic inguinal hernia repair. One of these is a slit on the mesh to surround the cord structures which proponents of it suggest that it decreases the recurrence rate due to better anchoring of the mesh and lower risk of displacement. There is only low‐level evidence in current literature examining the two methods. The present study aimed to provide stronger evidence in establishing whether the slit mesh technique is superior to the non‐slit mesh technique.MethodsThe reporting of this systematic review was guided by the standards of the preferred reporting items for systematic review and meta‐analysis statement and registered with PROSPERO (ID: CRD42022300629). Eligible studies had to compare the two methods of mesh placement slit Vs nonslit in laparoscopic Inguinal hernia repair and also report on at least one outcome. The outcomes were expressed in odd ratios with their 95% confidence intervals. Where significant heterogeneity existed a random effects model was used otherwise a fixed effects model was used.ResultsFive studies met the criteria for inclusion in quantitative analysis. Overall, there were 10 (1.5%) recurrences in the slit group compared to 12 (2.5%) in the non‐slit group OR 0.62, 95% CI (0.27–1.41). There was no difference in the incidence of post‐operative bleeding (OR 1.21, 95%CI 0.4–3.66), seroma formation (OR1.5, 95% CI 0.81–2.76), or post‐operative neuralgia (OR 0.98, 95%CI 0.11–8.92) between the two groups.ConclusionThere was no difference between the two methods.
Effect of risankizumab on health‐related quality of life in patients with Crohn's disease: results from phase 3 MOTIVATE, ADVANCE and FORTIFY clinical trials
Authors: Peyrin‐Biroulet Laurent , Ghosh Subrata , Lee Scott D. , Lee Wan‐Ju , Griffith Jenny , Wallace Kori , Berg Sofie , Liao Xiaomei , Panes Julian , Loftus Edward V. , Louis Edouard 
Published: October 2022

SummaryBackgroundCrohn's disease has a substantial negative impact on health‐related quality of life (HRQoL).AimTo examine the effects of risankizumab on HRQoL in Crohn's diseaseMethodsWe analysed data from patients with Crohn's disease from 12‐week induction trials ADVANCE (N = 850) and MOTIVATE (N = 569) with risankizumab 600 mg or 1200 mg intravenous (IV) versus placebo IV and a 52‐week maintenance trial FORTIFY (N = 462) with risankizumab 180 or 360 mg subcutaneous (SC) versus placebo SC. Outcomes included Inflammatory Bowel Disease Questionnaire (IBDQ), Functional Assessment of Chronic Illness Therapy‐Fatigue (FACIT‐F), 36‐item Short Form Health Survey (SF‐36), EuroQol 5‐Dimension‐5‐Level (EQ‐5D‐5L) and work productivity. The mean change and percentages of patients achieving clinically meaningful improvement in all outcomes were determined at weeks 12 and 52.ResultsAt week 12, more patients in the risankizumab 600 or 1200 mg groups achieved IBDQ response than with placebo (ADVANCE: 70.2%, 75.5% vs. 47.8%, p ≤ 0.001; MOTIVATE: 61.7%, 68.5% vs. 48.2%, p ≤ 0.01) and FACIT‐F response (ADVANCE: 51.3%, 48.0% vs. 35.7%, p ≤ 0.01; MOTIVATE: 44.2%, 49.1% vs. 33.7%, p < 0.05). These improvements persisted at week 52 with risankizumab maintenance treatment. Similar trends were observed for SF‐36 physical and mental component summary scores, EQ‐5D‐5L and activity impairment within work productivity measures.ConclusionsRisankizumab induction therapy (600 or 1200 mg IV) led to clinically meaningful improvements in disease‐specific and general patient‐reported outcomes, including fatigue, in patients with moderate to severe Crohn's disease. These improvements were sustained after 52 weeks of risankizumab (180 or 360 mg SC) maintenance therapy.
External governance pressure and corporate environmental responsibility: Evidence from a quasi‐natural experiment in China
Authors: Liu Qiang , Yu Lianchao , Yan Guowan , Guo Yu 
Published: October 2022

AbstractIn recent years, the Audit Pilot of Natural Resources Assets (APNRA) pilot program has been implemented by the Chinese government to strengthen the protection of natural resources and the ecological environment. Based on the APNRA pilot program, we use the multi‐period differences–in–differences model to investigate the response of corporate environmental responsibility to external governance pressure. We find that firms significantly improve their environmental investment and performance after the implementation of the APNRA pilot program. Sewage charges (including green fees) and ecological protection incentives constitute the two main channels that explain the positive relationship. We further find that the impact of the program on corporate environmental investment and performance is more pronounced for firms in regions with poor environmental quality, and for firms in heavy‐polluting industries. This paper introduces the role of government governance in generating positive externality for firms and provides a valuable understanding of environmental governance in an emerging market.
A novel approach for characterization of KSHV‐associated multicentric Castleman disease from effusions
Authors: Zhou Ting , Yuan Constance M. , Lurain Kathryn , Rous Clarissa , Weaver Linda , Raffeld Mark , Stetler‐Stevenson Maryalice , Uldrick Thomas S. , Filie Armando C. , Pittaluga Stefania , Jaffe Elaine S. , Marshall Vickie , Moore Kyle , Whitby Denise , Ramaswami Ramya , Yarchoan Robert , Wang Hao‐Wei 
Published: October 2022

SummaryA biopsy of lymphoid tissue is currently required to diagnose Kaposi sarcoma‐associated herpesvirus (KSHV)‐associated multicentric Castleman disease (KSHV–MCD). Patients showing clinical manifestations of KSHV–MCD but no pathological changes of KSHV–MCD are diagnosed as KSHV inflammatory cytokine syndrome. However, a lymph node biopsy is not always feasible to make the distinction. A pathognomonic feature of lymph nodes in KSHV–MCD is the expansion of KSHV‐infected, lambda‐restricted but polyclonal plasmablasts. To investigate whether these cells also reside in extra‐nodal sites, effusion from 11 patients with KSHV–MCD and 19 with KSHV inflammatory cytokine syndrome was analysed by multiparametric flow cytometry. A distinct, lambda‐restricted plasmablastic population (LRP) with highly consistent immunophenotype was detected in effusions in 8/11 patients with KSHV–MCD. The same population was also observed in 7/19 patients with KSHV inflammatory cytokine syndrome. The detection of LRP stratified KSHV inflammatory cytokine syndrome into two clinically distinct subgroups; those with detectable LRP closely resembled KSHV–MCD, showing similar KSHV viral load, comparable severity of thrombocytopenia and hypoalbuminaemia, and similar incidences of hepatosplenomegaly. Collectively, the detection of LRP by flow cytometry can serve as a valuable tool in diagnosing KSHV–MCD. KSHV inflammatory cytokine syndrome with LRP in effusions may represent a liquid‐form of KSHV–MCD.
Early progression in follicular lymphoma in the absence of histological transformation or high‐risk Follicular Lymphoma International Prognostic Index still has a favourable outcome
Authors: Muntañola Ana , Mozas Pablo , Mercadal Santiago , Huguet Maria , Bobillo Sabela , Bastos‐Oreiro Mariana , Jiménez‐Ubieto Ana , Rovira Jordina , Rivero Andrea , Tolosa Carles , Luizaga Luis , de Villambrosia Sonia González , Novelli Silvana , Caballero Dolores , Salar Antonio , Alonso‐Álvarez Sara , Magnano Laura , Gutiérrez Norma C. , Sancho Juan‐Manuel , López‐Guillermo Armando ,   the GELTAMO group (Grupo Español de Linfomas y Trasplante de Médula Ósea)
Published: October 2022

SummaryAlthough follicular lymphoma (FL) patients relapsing within 24 months after first‐line treatment (POD24) have a poor prognosis, some cases show notable survival after first relapse (SF1R). We aimed to characterize the POD24 FL population and to identify the main prognostic factors at progression. We selected 162 POD24 patients (80F; median age at first relapse 59 years) from a cohort of 1067 grades 1‐3a FL‐treated patients. The remaining 905 patients treated with first‐line immunochemotherapy and diagnosed during the same period were used to compare outcomes in terms of survival. After a median follow‐up of 11.0 years, 96 patients died (10y‐SF1R of 40%). Age over 60 years (p < 0.001), high lactate dehydrogenase (LDH) (p < 0.001), haemoglobin (Hb) less than 120 g/L (p < 0.001), advanced stage (p < 0.001), high‐risk Follicular Lymphoma International Prognostic Index (FLIPI) (p < 0.001), histological transformation (HT) (p < 0.001) and reaching less than complete response (CR) after salvage therapy (p < 0.001), predicted poor SF1R at relapse. In multivariate analysis only high‐risk FLIPI and HT maintained prognostic significance for SF1R. POD24 patients not transformed and with low/intermediate FLIPI at relapse behaved better than the remaining cases. POD24 patients showed an excess mortality of 38% compared to the general population. Although outcome of POD24 FL patients is poor, a considerable group of them (low/intermediate FLIPI and not transformed at first relapse) behave better.
Utility of screening for silent myocardial ischaemia in diabetes with an annual electrocardiogram
Authors: O'Murchadha Liam , Egan Aoife M , Cahill Kathleen , Flynn Carly , O'Flynn Dearbhail , O'Neill James , Sreenan Seamus , McDermott John H 
Published: October 2022

AbstractBackground and MethodsAsymptomatic coronary artery disease (CAD) is common in people with diabetes mellitus, but there is a lack of consensus regarding appropriate screening for the condition. We performed a 12‐lead electrocardiogram (ECG) on 312 consecutive participants with diabetes mellitus attending for routine annual outpatient review in order to determine the effectiveness of a yearly ECG in screening people with diabetes for asymptomatic CAD.ResultsThree of 312 participants (0.96%, 95% CI 0.2%–2.78%) had a newly identified ECG abnormality. One person had newly discovered atrial fibrillation. Two people had abnormalities which prompted further investigation for asymptomatic CAD. One of these participants underwent percutaneous coronary intervention. Seventeen further participants had abnormalities on ECG which had been previously documented, the majority having been present since their diagnosis of diabetes.ConclusionA low positive yield of routine annual ECG in our study does not support its use as a screening tool for asymptomatic CAD in diabetes. Our findings support advice to perform an ECG at diagnosis of diabetes and to repeat only if a person develops relevant symptoms.
Continuous glucose monitoring‐based time‐in‐range using insulin glargine 300 units/ml versus insulin degludec 100 units/ml in type 1 diabetes: The head‐to‐head randomized controlled InRange trial
Authors: Battelino Tadej , Danne Thomas , Edelman Steve V. , Choudhary Pratik , Renard Eric , Westerbacka Jukka , Mukherjee Bhaswati , Pilorget Valerie , Coudert Mathieu , Bergenstal Richard M. 
Published: October 2022

AbstractAimTo use continuous glucose monitoring (CGM)‐based time‐in‐range (TIR) as a primary efficacy endpoint to compare the second‐generation basal insulin (BI) analogues insulin glargine 300 U/ml (Gla‐300) and insulin degludec 100 U/ml (IDeg‐100) in adults with type 1 diabetes (T1D).Materials and MethodsInRange was a 12‐week, multicentre, randomized, active‐controlled, parallel‐group, open‐label study comparing glucose TIR and variability between Gla‐300 and IDeg‐100 using blinded 20‐day CGM profiles. The inclusion criteria consisted of adults with T1D treated with multiple daily injections, using BI once daily and rapid‐acting insulin analogues for at least 1 year, with an HbA1c of 7% or higher and of 10% or less at screening.ResultsOverall, 343 participants were randomized: 172 received Gla‐300 and 171 IDeg‐100. Non‐inferiority (10% relative margin) of Gla‐300 versus IDeg‐100 was shown for the primary endpoint (percentage TIR ≥ 70 to ≤ 180 mg/dl): least squares (LS) mean (95% confidence interval) 52.74% (51.06%, 54.42%) for Gla‐300 and 55.09% (53.34%, 56.84%) for IDeg‐100; LS mean difference (non‐inferiority): 3.16% (0.88%, 5.44%) (non‐inferiority P = .0067). Non‐inferiority was shown on glucose total coefficient of variation (main secondary endpoint): LS mean 39.91% (39.20%, 40.61%) and 41.22% (40.49%, 41.95%), respectively; LS mean difference (non‐inferiority) −5.44% (−6.50%, −4.38%) (non‐inferiority P < .0001). Superiority of Gla‐300 over IDeg‐100 was not shown on TIR. Occurrences of self‐measured and CGM‐derived hypoglycaemia were comparable between treatment groups. Safety profiles were consistent with known profiles, with no unexpected findings.ConclusionsUsing clinically relevant CGM metrics, InRange shows that Gla‐300 is non‐inferior to IDeg‐100 in people with T1D, with comparable hypoglycaemia and safety profiles.
Tooth in the line of a mandibular fracture: Retain it or remove it? Clinical case report
Authors: Arcila Verónica Gómez , Correa Cristhian Ruiz , Castellar‐Mendoza Camilo 
Published: October 2022

AbstractDefining the prognosis and treatment plan for teeth in the line of a mandibular fracture is a challenge for the maxillofacial surgeon. The periodontal ligament may provide a communication with the oral cavity and become a pathway for infection. There is currently no consensus on the management of teeth in mandibular fracture lines. This report outlines a case where a tooth was successfully retained in the line of fracture as well as providing a review of the literature on the best‐accepted treatments for this scenario.
From Rome to Ripoll, Rioja, and beyond: the Iberian transmission of the Latin Tiburtine Sibyl and Oliba of Ripoll and Vic’s Europe‐wide network of knowledge transfer and learning
Authors: Tischler Matthias M. 
Published: October 2022

In memory of Ernst Sackur (1862–1901)The Catalan abbot‐bishop Oliba of Ripoll and Vic (1008–46) was a remarkably learned man, with religious and cultural connections to many European regions beyond Catalonia. When he died, a letter commemorating his life and death circulated from Ripoll through many religious institutions of Catalonia, Septimania, and Western Francia, showing the wide‐ranging network he had developed during his lifetime. However, Oliba also had another important religious and cultural orientation – towards Italy in general and Rome in particular. In the light of widely unknown or disregarded Catalan and northern Iberian copies of the so‐called Tiburtine Sibyl from the early eleventh century onwards, this article highlights the historical and social circumstances of the early transfer of this new product of Greco‐Latin translation activity. This one example stands for many further text transmission activities in Oliba’s life, spread through the networks he had established between Rome, Italy, his home region Catalonia, and the northern Iberian world.
Prioritization process for European Academy of Neurology clinical practice guidelines
Authors: Aleksovska Katina , Bassetti Claudio L. A. , Berger Thomas , Carvalho Vanessa , Costa Joao , Deuschl Günther , Frederiksen Kristian S. , Jaarsma Joke , Kobulashvili Teia , Leone Maurizio , Pavlakova Lucia , Romoli Michele , Vignatelli Luca 
Published: October 2022

AbstractBackground and purposeThe development of high‐quality clinical practice guidelines (CPGs) takes substantial time, effort, and resources. During the past years, the European Academy of Neurology (EAN) guideline production was significantly increased, so the need to develop clear, transparent, and methodologically solid criteria for prioritizing guideline topics became apparent. With this paper, we aim to define a set of criteria to be applied for prioritizing topics for future EAN guidelines, as well as the procedure for their implementation.MethodsAfter review of the literature, we identified a recent systematic review that reported on the main prioritization criteria used by health organizations. Based on these, we developed a list of 20 preliminary criteria, which were voted on through a Delphi consensus procedure, including 160 stakeholders. Finally, we established a working procedure on how to submit and select new guideline topic proposals within the EAN. This procedure was reviewed by the EAN Scientific Committee and the Board.ResultsThe first round, 61.3% of the participants voted, and 86% of them participated in the second round. Seven criteria were approved with this procedure. After the selection of the criteria, a prioritization procedure was launched, and the first 30 topics are reported in this paper. This bottom‐up process that involved the whole EAN community was followed by a top‐down process, using additional criteria for further selection by the EAN board members.ConclusionsWe describe the development of prioritization criteria to be applied in the process of topic selection for future EAN CPGs. We will perform regular reviews and adjustments of the process.
Management of epilepsy in older adults: A critical review by the ILAE Task Force on Epilepsy in the elderly
Authors: Piccenna Loretta , O'Dwyer Rebecca , Leppik Ilo , Beghi Ettore , Giussani Giorgia , Costa Cinzia , DiFrancesco Jacopo C. , Dhakar Monica B. , Akamatsu Naoki , Cretin Benjamin , Krämer Günter , Faught Edward , Kwan Patrick 
Published: October 2022

AbstractOlder adults represent a highly heterogeneous population, with multiple diverse subgroups. Therefore, an individualized approach to treatment is essential to meet the needs of each unique subgroup. Most comparative studies focusing on treatment of epilepsy in older adults have found that levetiracetam has the best chance of long‐term seizure freedom. However, there is a lack of studies investigating other newer generation antiseizure medications (ASMs). Although a number of randomized clinical trials have been performed on older adults with epilepsy, the number of participants studied was generally small, and they only investigated short‐term efficacy and tolerability. Quality of life as an outcome is often missing but is necessary to understand the effectiveness and possible side effects of treatment. Prognosis needs to move beyond the focus on seizure control to long‐term patient‐centered outcomes. Dosing studies with newer generation ASMs are needed to understand which treatments are the best in the older adults with different comorbidities. In particular, more high‐level evidence is required for older adults with Alzheimer's disease with epilepsy and status epilepticus. Future treatment studies should use greater homogeneity in the inclusion criteria to allow for clearer findings that can be comparable with other studies to build the existing treatment evidence base.
Reflectance confocal microscopy in paediatric patients: Applications and limits
Authors: Scharf Camila , Di Brizzi Eugenia Veronica , Licata Gaetano , Piccolo Vincenzo , Argenziano Giuseppe , Moscarella Elvira 
Published: October 2022

AbstractReflectance confocal microscopy (RCM) is a non‐invasive diagnostic tool extensively studied for adult patients. In this retrospective case series conducted at the Dermatology Unit of the University of Campania, Naples, Italy, all patients under 19 years old who were submitted to RCM from January 2011 to December 2021 where evaluated. The aim of the study was to review the most usual indications and possible benefits that it might add for children. Data collection included 215 patients (86 males and 129 females, mean age: 12). Most of the exams (n = 85; 39.5%) were performed for lesions clinically compatible with Spitz nevi, congenital nevi (n = 50 23,2%) and atypical melanocytic lesions (n = 46; 21%) among which two melanomas were detected. RCM can be an useful instrument when evaluating paediatric patients and may help avoid unnecessary biopsy in most cases, representing an additional instrument to improve diagnostic accuracy.
Development and implementation of a relationship‐focused outpatient multifamily program for adolescent anorexia nervosa
Authors: Cook‐Darzens Solange , Duclos Jeanne 
Published: October 2022

AbstractMultifamily therapy (MFT) for adolescent eating disorders (ED) is anchored in systemic theory and family therapy, but two conceptual and practical paths have emerged from this common framework. The first one, called ED‐focused MFT, is centered on behavioral change and weight gain in the early stages of treatment, while the second, known as relationship‐focused MFT, is less directly focused on symptom improvement and more on family changes. Compared to ED‐focused MFT, validation of more relationship‐focused MFT models has been lagging behind although they are frequently implemented and practiced in Europe. The purpose of this article is to give more visibility to existing relationship‐focused MFT models by presenting an integrative, yet predominantly family‐oriented MFT program developed for adolescent anorexia nervosa (AN) (12 to 18 years) on the ED unit of a large pediatric hospital in France. After presenting the history and development of this relationship‐focused MFT program, including the challenges it encountered and its evaluation, we describe its rationale and objectives, then outline its course and content, giving illustrations of techniques and activities for each of the five phases of the program. Finally, we review the current status of this model, its advantages and limitations, and provide a critical appraisal of existing evidence and recommended future research directions.
Overcoming interruptions in educational trajectories: Youth in Ghana with international migrant parents
Authors: Osei Onallia Esther , Haagsman Karlijn , Mazzucato Valentina 
Published: October 2022

AbstractLiterature on the effects of parental migration on the education of children who stay at origin, what we call ‘stayer’ youth, mainly focuses on educational outcomes without looking at the process leading to such outcomes. This article addresses this gap by showing how the educational trajectories of stayer youth unfold. Stayer youth may encounter a range of obstacles and interruptions to their education when their parents move overseas, and we explore the agency these youth exert and the support networks they activate to try to overcome them. We employ a youth‐centric methodology, based on 15 months of ethnographic fieldwork in three cities in Ghana, with young people whose parents migrated internationally. We find that frequent changes in residence, limited financial means, and lack of academic support cause interruptions in educational trajectories. In response, the young people mobilize support from local social networks to compensate for what they lack from their transnational connections.