bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparative genomics reveals low levels of inter- and intraspecies diversity in the causal agents of dwarf and common bunt of wheat and hint at conspecificity of Tilletia caries and T. laevis
Authors: Sedaghatjoo Somayyeh , Mishra Bagdevi , Forster Monika K. , Becker Yvonne , Keilwagen Jens , Killermann Berta , Thines Marco , Karlovsky Petr , Maier Wolfgang 
Published: June 2022

AbstractTilletia caries and T. laevis, which are the causal agents of common bunt, as well as T. controversa, which causes dwarf bunt of wheat, threaten especially organic wheat farming. The three closely related fungal species differ in their teliospore morphology and partially in their physiology and infection biology. The gene content as well as intraspecies variation in these species and the genetic basis of their separation is unknown. We sequenced the genome of four T. caries, five T. controversa, and two T. laevis and extended this dataset with five publicly available ones. The genomes of the three species displayed microsynteny with up to 94.3% pairwise aligned regions excluding repetitive regions. The majority of functionally characterized genes involved in pathogenicity, life cycle, and infection of corn smut, Ustilago maydis, were found to be absent or poorly conserved in the draft genomes and the biosynthetic pathway for trimethylamine in Tilletia spp. could be different from bacteria. Overall, 75% of the identified protein-coding genes comprising 84% of the total predicted carbohydrate utilizing enzymes, 72.5% putatively secreted proteins, and 47.4% of effector-like proteins were conserved and shared across all 16 isolates. We predicted nine highly identical secondary metabolite biosynthesis gene clusters comprising in total 62 genes in all species and none were species-specific. Less than 0.1% of the protein-coding genes were species-specific and their function remained mostly unknown. Tilletia controversa had the highest intraspecies genetic variation, followed by T. caries and the lowest in T. laevis. Although the genomes of the three species are very similar, employing 241 single copy genes T. controversa was phylogenetically distinct from T. caries and T. laevis, however these two could not be resolved as individual monophyletic groups. This was in line with the genome-wide number of single nucleotide polymorphisms and small insertions and deletions. Despite the conspicuously different teliospore ornamentation of T. caries and T. laevis, a high degree of genomic identity and scarcity of species-specific genes indicate that the two species could be conspecific.
Mineralizing microangiopathy: radiological features of a "not uncommon" complication of chemoradiotherapy in pediatric cancer patients
Authors: Youssef Ayda , Madney Youssef , Zaghloul Mohamed , Heikal Samia 
Published: June 2022

Abstract
Background
Mineralizing microangiopathy represents one of the delayed complications of radiotherapy and chemotherapy. We reviewed clinical and radiological data of pediatric cancer patients who presented with mineralizing microangiopathy. This is a retrospective analysis of the medical records of 37 cancer children treated with chemoradiotherapy presented with imaging criteria suspected of mineralizing microangiopathy admitted to our hospital during the period 2015–2020. The CT was reviewed for distribution of calcification and MRI for signal criteria.
This study aims to raise awareness among radiologists about radiological features of mineralizing microangiopathy during the sequential routine follow-up brain scans of pediatric cancer patients who received chemo, radio, or combined chemoradiotherapy and to identify changes as a long-term delayed complication of therapy and avoid misdiagnosis.

Results
Thirty-seven pediatric cancer patients (17 female and 20 males, aged 1.5–18 years) who had mineralizing microangiopathy were thoroughly investigated. Most of them (32 patients) had brain tumors and 5 patients had leukemia. Cranial radiotherapy and systemic chemotherapy were given to 33 patients, while nine patients received intrathecal chemotherapy. The interval needed to develop mineralizing microangiopathy ranged from 1 to 10 years after the end of treatment. CT detected calcification in the basal ganglia, being the most common location (32 cases), followed by cerebral gray–white matter interface in 26 patients, cerebellum (18), brain stem (13), thalamus (5), and caudate nucleus (4), while dural calcifications were found in only one patient. MRI was considered “positive” when T1 hyperintensity was noted in the anatomical location of CT detected calcification; it was positive in 29 cases.

Conclusion
Mineralizing microangiopathy is one of the delayed complications of chemoradiotherapy among pediatric cancer patients. The awareness of its radiological criteria is essential to avoid misdiagnosis. Early detection can alert pediatric oncologists to monitor neurotoxicity and help prevent long-term neurological sequels.
Breast Medical Oncologists' Perspectives of Telemedicine for Breast Cancer Care: A Survey Study
Authors: Stavrou Eleni , Qiu Jeanna , Zafar Affan , Tramontano Angela C. , Isakoff Steven , Winer Eric , Schrag Deborah , Manz Christopher 
Published: June 2022

PURPOSE: The COVID-19 pandemic forced rapid adoption of telemedicine (TM) for breast oncology visits in the United States, but the appropriate role of postpandemic TM is uncertain. We sought to understand physician and advance practice practitioner perspectives on the use of TM for outpatient breast cancer care through an electronically administered survey. METHODS: Breast medical oncology clinicians at two academic cancer centers and five satellite locations affiliated with the Dana Farber Cancer Institute and the Massachusetts General Cancer Center were invited to respond to a 21-question survey administered in September 2021 about clinicians' perceptions and attitudes toward TM during the previous 12 months. RESULTS: Of the 71 survey invitations, 51 clinicians (36 physicians and 15 advance practice practitioners) provided survey responses (response rate = 72%). Ninety-two percent of respondents (n = 47) agreed that TM visits enhance patient care. Ninety-two percent of respondents (n = 46) also agreed that TM is valuable for early-stage breast cancer follow-up visits. Most respondents felt that there was no difference between TM and face-to-face (F2F) visits when it came to patient adherence, ease of ordering tests, ease of accessing patient records, and workflow outside of the visit (82%, 82%, 78%, and 53%, respectively). Fifty-one percent of respondents (n = 26) said that TM was better for timely access to follow-up appointments. Most respondents said that F2F visits were better for seeing physical problems, personal connection with patients, overall quality of visits, and patient-physician communication (100%, 75%, 65%, and 63%, respectively). CONCLUSION: Breast clinicians believe that TM is a valuable tool to enhance outpatient breast cancer care. TM was felt to be appropriate for routine follow-up visits and second opinion consultations and is as good as or better than F2F visits for several routine aspects of breast cancer care.
Climate Insurgency between Academia and Activism
Authors: Armiero Marco , De Rosa Salvatore Paolo 
Published: June 2022

Abstract
This interview focuses on a spectrum of urgent challenges facing marginalized human and other-than-human communities, including the intersecting crises of global anthropogenic climate disruption and state and institutional racist violence. We discuss and consider the opportunities, limits, and contradictions of pursuing transformative, intersectional political change and scholarship through efforts to bridge community activism and academic labor. We also critically engage questions concerning the role of the state in the context of racial capitalism and the production of environmental and climate injustice, and how grassroots movements have responded to these concerns. Specific movement formations included in this discussion include the Central Coast Climate Justice Network of California, the Movement for Black Lives/Black Lives Matter, Extinction Rebellion, and multispecies abolition democracy. The importance of radical, multi-issue politics and cross-movement solidarities is also given serious attention.
Beta-Delta or Delta-Tau? A Reformulation of Quasi-Hyperbolic Discounting
Authors: Bleichrodt Han , Potter van Loon Rogier J. D. , Prelec Drazen 
Published: June 2022

This paper introduces the index [Formula: see text] as a measure of time inconsistency and vulnerability to self-control problems in the quasi-hyperbolic, beta-delta ([Formula: see text] discounting model. We provide a preference foundation for [Formula: see text] and, consequently, a revealed preference definition of failed self-control. The [Formula: see text] index is independent of utility and has an intuitive interpretation as the maximum number of future selves who can disagree with the current self with respect to uniform deviations from an intertemporal plan. The index is also computable for continuous discount functions after an appropriate mapping of functions onto the ([Formula: see text] family. The [Formula: see text] index thus provides a common yardstick for comparing temporal inconsistency across different functional forms. This paper was accepted by Manel Baucells, behavioral economics and decision analysis.
Nutritional and health status of a cohort of school-age children born to mothers treated for severe acute malnutrition in their childhood in The Democratic Republic of Congo
Authors: Murhima’Alika Christine Chimanuka , Balolebwami Zigabe Serge , Bahati Lufungulo Yvette , Mwene-Batu Lyabayungu Pacifique , Garhalangwa Mayeri Daniel , Gaylord Amani Ngaboyeka , Dramaix Michèle , Donnen Philippe , Bisimwa Balaluka Ghislain 
Published: June 2022

Background
Malnutrition is a public health problem, but outside the theoretical framework, little is known about the concrete intergenerational effects of malnutrition.

Objective
The objective of this study is to compare the nutritional status and health indicators of school children born to mothers who were treated for severe acute malnutrition (SAM).

Methodology
The study took place in Miti-Murhesa health zone in the Democratic Republic of Congo. This is a cohort study assessing the nutritional and health status of school children born to mothers who had been treated for SAM, based on WHZ or edema, in Lwiro hospital between 1988–2002 compared to children born to mothers who were not exposed to SAM. Stunting and thinness were evaluated by Height for Age Z-score (HAZ) and Body Mass Index by Age criteria (BMIAZ) respectively. On admission, blood samples were taken to assess anemia, HIV serology, hemogram and others biological indicators. Stool’s examinations were conducted by using Olympus optical microscope. Parametric and non-parametric tests were applied to compare the different variables in two groups.

Results
We identified 106 children aged 5–16 years (103 exposed and 58 unexposed) and we received 83.5% and 91.4% children respectively for anthropometric parameters. The mean of age was 7.9 ± 2.4 year in exposed group and 7.4 ± 2.1 year in unexposed group (p = 0.26). The prevalence of stunting was 68.3% in the exposed group and 67.3% in the unexposed group (p = 0.90). The prevalence of thinness was 12.8% in the exposed group and 9.6% in the unexposed group (p = 0.57). The biological profile (glycemia, urea, creatinine and hemogram) and the prevalence of intestinal parasites were similar in the two groups.

Conclusion
In this sample, in a malnutrition-endemic area, there was no statistically significant difference in nutrition and health indicators between school children born to mothers exposed to SAM and their community controls.
Terapia focada na compaixão online para a perturbação de ansiedade social na adolescência (CFT@TeenSAD)
Authors: Vieira Figueiredo Diana , Ganho-Ávila Ana , Ramos Miguel Rita , Paulo Marlene , Nobre-Lima Luiza , Salvador Maria do Céu , Rijo Daniel , Vagos Paula Emanuel Rocha 
Published: June 2022

Este trabalho investigou a eficácia da Terapia Focada na Compaixão (TFC) nos sintomas da perturbação de ansiedade social (PAS) na adolescência, com base em dados recolhidos ao longo da intervenção. A TFC contribuiu para o bem-estar psicológico em várias populações, mas é escassa a evidência sobre a sua eficácia no tratamento da PAS em adolescentes. Vinte e um adolescentes (57.1% raparigas; 15-18 anos) com PAS receberam tratamento online. A intervenção CFT@TeenSAD foi organizada em quatro módulos sequenciais: A mente de acordo com a TFC, Promoção do eu-compassivo e de competências para uma mente compassiva, Prática de comportamento compassivo, Últimas notas e continuar numa viagem compassiva. Antes de cada sessão, os adolescentes reportaram mudança percebida na gravidade dos sintomas e os clínicos fizeram essa avaliação no final de cada sessão. Tanto os adolescentes (F (1.540) = 32.271, p<0.0005, ηp2 = 0.63) como os clínicos (F (1.528) = 24.783, p< 0.0005, ηp2= 0.57) relataram melhoria continuada ao longo do tratamento, com mudança significativa ao longo dos quatro módulos. As trajetórias de mudança foram semelhantes para rapazes e raparigas. A TFC surge como uma abordagem promissora na PAS em adolescentes, contribuindo para a diminuição contínua da gravidade dos sintomas.
Functional and Stylistic Aspects of Foreign Toponyms Used in the Literary Texts of Michael Matusovsky
Authors: Dyakova Tatyana 
Published: June 2022

Various aspects of the study of toponymic vocabulary in modern linguistics are analyzed, the principles of distinguishing foreign language toponymic units in the literary texts of M. Matusovsky are described. Various groups of toponyms from the writer's works are studied. The statistics of the toponymic units use is presented. The stylistic features of the use of foreign toponyms in the writer's poetic and prose works are studied. The main functions of toponym usage are: depiction of local, historical aspects as well as landscape peculiarities and a real image of the environment. Among the figures of speech with toponyms, the most common are antithesis, epiphora, parallelism. Toponyms are also used in the formation of rhetoric speeches, they perform a rhythmic and intonation function.
The Concept of “Easy Language” and its Perspectives in Linguistics
Authors: Osokina Svetlana 
Published: June 2022

The article is of theoretical content and aimed at description of the current foundations for the concept of “easy language” as well as its further research perspectives in linguistics. The author examines the terminological status of the expression “easy language” taking into account available scientific views on the problem and comparative semantic analysis of the words used for naming the key concept by different researchers. The article provides discussion of research papers published in Russia and abroad. Among the further perspectives of the development of the “easy language” concept, the author considers to be cognitive studies, sociolinguistics, text theory, and translation theory. The conclusion is that further development of the concept of “easy language” is necessary and relevant because it is focused on creation a special language subsystem to help people with communication difficulties, especially those with cognitive impairments and learning difficulties, to avoid communication breakdowns caused by standard language processing.
Effect of Obesity on Risk of Hospitalization, Surgery, and Serious Infection in Biologic-Treated Patients With Inflammatory Bowel Diseases: A CA-IBD Cohort Study
Authors: Gu Phillip , Luo Jiyu , Kim Jihoon , Paul Paulina , Limketkai Berkeley , Sauk Jenny S. , Park Sunhee , Parekh Nimisha , Zheng Kai , Rudrapatna Vivek , Syal Gaurav , Ha Christina , McGovern Dermot P. , Melmed Gil Y. , Fleshner Phillip , Eisenstein Samuel , Ramamoorthy Sonia , Dulai Parambir S. , Boland Brigid S. , Grunvald Eduardo , Mahadevan Uma , Ohno-Machado Lucila , Sandborn William J. , Singh Siddharth 
Published: June 2022

INTRODUCTION:
Obesity is variably associated with treatment response in biologic-treated patients with inflammatory bowel diseases (IBD). We evaluated the association between obesity and risk of hospitalization, surgery, or serious infections in patients with IBD in new users of biologic agents in a large, multicenter, electronic health record (EHR)-based cohort (CA-IBD).

METHODS:
We created an EHR-based cohort of adult patients with IBD who were new users of biologic agents (tumor necrosis factor [TNF-α] antagonists, ustekinumab, and vedolizumab) between January 1, 2010, and June 30, 2017, from 5 health systems in California. Patients were classified as those with normal body mass index (BMI), overweight, or obese based on the World Health Organization classification. We compared the risk of all-cause hospitalization, IBD-related surgery, or serious infections among patients with obesity vs those overweight vs those with normal BMI, using Cox proportional hazard analyses, adjusting for baseline demographic, disease, and treatment characteristics.

RESULTS:
Of 3,038 biologic-treated patients with IBD (69% with Crohn's disease and 76% on TNF-α antagonists), 28.2% (n = 858) were overweight, and 13.7% (n = 416) were obese. On a follow-up after biologic initiation, obesity was not associated with an increased risk of hospitalization (adjusted hazard ratio [aHR] vs normal BMI, 0.90; [95% confidence interval, 0.72–1.13]); IBD-related surgery (aHR, 0.62 [0.31–1.22]); or serious infection (aHR, 1.11 [0.73–1.71]). Similar results were observed on stratified analysis by disease phenotype (Crohn's disease vs ulcerative colitis) and index biologic therapy (TNF-α antagonists vs non–TNF-α antagonists).

DISCUSSION:
In a multicenter, EHR-based cohort of biologic-treated patients with IBD, obesity was not associated with hospitalization, surgery, or serious infections. Further studies examining the effect of visceral obesity on patient-reported and endoscopic outcomes are needed.
Algumas concepções sobre o fracasso escolar no Brasil
Authors: Oliveira Marília Villela de 
Published: June 2022

Resumo: Nosso objetivo é apontar alguns dos vários mascaramentos presentes nas concepções sobre o fracasso escolar e, atualmente, no discurso do "respeito à diversidade". A luta contra o fracasso escolar tem-se pautado no respeito às diferenças culturais presentes na mesma organização social, mas essa concepção, se simplificada ou fragmentada, pôe em risco as possibilidades reais de criação de novas formas de organisação social e escolar. O processo de globalização econômica e a tendência a possibilidades de homogeneização cultural podem ampliara o quadro referencial de reflexão sobre a diversidade, mas, ao mesmo tempo, pode decapitá-lo em sua ações concretas. A partir da teoria do curriculo e do desvelamento das diferentes concepções de diversidade é possível superar a fragmentação da prática pedagógica escolar e das nossas concepções dobre o sucesso e o fracasso dentro dela e, mais ainda, pressupor uma nova perspectiva de organização/transformação social, fundamentada no já vivido e consolidado no cotidiano das relações sociais.

Abstract: Our intent is to point out some of the many masks envolving the conceptions of school failure and, nowadays, the discourse about "respect to diversity". The fight against school failure is being supported on the respect for cultural differences exhisting in a single social organization, but this conception, when simplified or fragmented, risks the real possibilities of creating new social and school organization forms. The economic organization process and the tendency to cultural homogenization can enlarge the paradigms for thinking about diversity, but, at the same time, it can make impossible effective actions supported by these paradigms. From curriculum theory and the unveiling of different conceptions of diversity, it's possible to surpass the fragmentation of pedagogic practice in school and, also, our ideas about success and failure in it. Furthermore, it's possible to presume the emergence of a new perspective of social organization/transformation, supported by a new utopia, based on experience and turned strong in everyday social relations.
Crise e democracia
Authors: Borges Bento Itamar 
Published: June 2022

Resumo: Esta conferência, apresentada a estudantes de Direito, trata da crise atual, enquanto crise do estado capitalista e analisa três riscos que a democracia corre em momentos de crise acirrada. Dois desses riscos são apontados por Habermas em alguns escritos - o misticismo irracionalista, que pode fomentar a falsa revolução e a recaída no fascismo, que tenta justificar-se, como na teoria política de Carl Schmitt - e um terceiro está presente na obra mesma de Habermas, a saber, a insuficiência de um conceito meramente formal da democracia que ele quer salvar sob o paradigma discursivo.

Abstract: This paper, which was originally a lecture for Law students, deals with the present crisis, by understanding it as the crisis of the capitalist State. The author also analyses three risks for democracy in such moments of overwhelming loss of identity. Two risks were already pointed out by Habermas, for instance, in some of his texts the irracionalist misticism, which can inspire the false revolution, and the return to fascism, such as happened in Carl Schmitt's attempt to justify it in his political theory. And a third risk is to be found in Habermas work itself, namely, a mere concept of democracy, such as developped in his late discourse paradigm, turns out to be too formal, with no material substance.
concepção sartriana de ego transcendental
Authors: Sass Simeão Donizeti 
Published: June 2022

Resumo: Este artigo trata da concepção de ego transcendental no pensamento de Jean-Paul Sartre. Especificamente temos a intenção de apresentar o modo como se constitui a perspectiva do ego como um objeto psiquico transcendente e as implicações dessa posição para a crítica ao solipsismo. Para efetuar essa tarefa Sartre toma como ponto de partida a idéia de intencionalidade.
Résumé: Cet article est au sujet de la conception de moi transcendantal dans la pensée de Jean-Paul Sartre. Spécifiquement nous avons l'intention de présenter le chemin comme la perspective du moi est constitué comme un objet transcendant et les implications de cette place pour la critique au solipsisme. Pour faire cette tâche Sartre il prend comme point de départ l'idée de l'intentionnalité.

Palavras-chave: ego; transcendencia; intencionalidade.
The ‘Aristotle Experience’ Revisited: Thomas Kuhn Meets Ludwik Fleck on the Road to

Structure
Authors: Jarnicki Paweł , Greif Hajo 
Published: June 2022

Abstract
This article takes issue with Kuhn’s description of the ‘Aristotle experience,’ an event that took place in 1947 and that he retrospectively characterized as a revelation that instantly delivered to him the key concepts of The Structure of Scientific Revolutions (1962). We trace a certain transformation of this narrative over time: whereas it commenced from a description of his impression of disparity between the textbook image of science and the study of historical sources, Kuhn started to characterize it as a revelation after learning of the English translation of Fleck’s 1935 Entstehung und Entwicklung einer wissenschaftlichen Tatsache. This book anticipates many central Kuhnian claims. Kuhn read it as early as 1949, but never fully acknowledged it as a source of inspiration. We discuss four hypotheses concerning the possible influence of Fleck’s theory on Kuhn’s in light of the available evidence. We conclude that the degree of similarity between them is too great to be coincidental.