bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical Characteristics, Transmission Rate and Outcome of Neonates Born to COVID-19-Positive Mothers: A Prospective Case Series From a Resource-Limited Setting
Authors: Rood Marloes , ten Kate Lisa , Boeddha Navin P. , van ‘t Kruys Kevin 
Published: December 2022

Background:Coronavirus disease (COVID-19) infection during pregnancy could damage the placenta, but data on neonates born to COVID-19-positive mothers is scarce. In this case series, we aim to describe clinical characteristics, transmission rate and outcomes at 3 months of age among neonates born to mothers with COVID-19 diagnosed near the time of delivery.Methods:Prospective, multicenter case series from Suriname. We collected clinical data of neonates born to mothers with COVID-19 infection between June and August 2021. COVID-19 swabs were taken within 5 days and 2 weeks after birth. Follow-up took place at 3 months.Results:We enrolled 18 neonates. However, 18/18 (100%) mothers were infected in the third trimester and 10/18 (55.6%) had severe COVID-19 infection requiring ICU admission and 2/10 (20%) died. In total 16/18 (77.8%) neonates were born after cesarean section and 13/18 (72.2%) were born preterm (median 35 weeks, Interquartile range 32 + 4–38 + 0). Neonatal intensive care unit admission was needed in 7/18 (38.9%) neonates. Respiratory symptoms occurred in 12/18 (66.7%), 5/18 (27.8%) were suspected of early-onset sepsis and 1/18(5.6%) of late-onset sepsis. One preterm neonate developed necrotizing enterocolitis. A nasopharyngeal swab was positive in 1/18 (5.5%) neonates within 5 days of life and in 0/11 (0%) neonates after 2 weeks. Follow-up showed mild neurodevelopmental delay in 2/14 (14.3%) patients.Conclusion:We describe a high proportion of severely ill mothers due to COVID-19 infection with subsequent cesarean delivery and prematurity. Accounting for gestational age at birth, the neonatal clinical course and findings at follow-up appeared similar to neonates born to COVID-19-negative mothers. Maternal vaccination is recommended to prevent neonatal risks associated with prematurity and cesarean delivery.
Historical eye: from traditional to endobronchial ultrasound-guided needle aspiration and beyond
Authors: Zuccatosta Lina , Mei Federico , Bonifazi Martina , Gasparini Stefano 
Published: December 2022

Purpose of review
In the history of bronchoscopy, the advent of flexible transbronchial needle aspiration (TBNA) before and, subsequently, of endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA), have represented fundamental events, as they have significantly and definitively changed interventional pulmonology's role in diagnostic and therapeutic work-up of most of thoracic diseases.
Purpose of this historical review is to retrace the main stages that have contributed to the development of these two techniques.

Recent findings
TBNA allowed the bronchoscopists to overcome the barrier of the tracheobronchial wall and to obtain samples from hilar-mediastinal lesions. With this additional method, bronchoscopy has become an essential procedure for staging of lung cancer.
The advent of echo-bronchoscopes, allowing to perform TBNA under direct ultrasound guidance in real time, further increased the diagnostic yield of this technique. Furthermore, the insertion of the echo-bronchoscope through the oesophagus allowed to extend the landscape of targets to sample, including also para-esophageal lesions, liver metastases, celiac nodes and left adrenal glands.
EBUS-TBNA has shown its usefulness not only in the approach to mediastinal lesions, but also in other clinical conditions, such as lung nodules or masses adjacent to the tracheobronchial tree.

Summary
Despite the obvious advantages of EBUS-TBNA, this technology is not yet available in many centres and countries worldwide. For this reason, TBNA remains a basic technique that must complete the technical background of bronchoscopists and it should not be forgotten.
Advances in bronchoscopic optical coherence tomography and confocal laser endomicroscopy in pulmonary diseases
Authors: Kramer Tess , Wijsman Pieta C. , Kalverda Kirsten A. , Bonta Peter I. , Annema Jouke T. 
Published: December 2022

Purpose of review
Imaging techniques play a crucial role in the diagnostic work-up of pulmonary diseases but generally lack detailed information on a microscopic level. Optical coherence tomography (OCT) and confocal laser endomicroscopy (CLE) are imaging techniques which provide microscopic images in vivo during bronchoscopy. The purpose of this review is to describe recent advancements in the use of bronchoscopic OCT- and CLE-imaging in pulmonary medicine.

Recent findings
In recent years, OCT- and CLE-imaging have been evaluated in a wide variety of pulmonary diseases and demonstrated to be complementary to bronchoscopy for real-time, near-histological imaging. Several pulmonary compartments were visualized and characteristic patterns for disease were identified. In thoracic malignancy, OCT- and CLE-imaging can provide characterization of malignant tissue with the ability to identify the optimal sampling area. In interstitial lung disease (ILD), fibrotic patterns were detected by both (PS-) OCT and CLE, complementary to current HRCT-imaging. For obstructive lung diseases, (PS-) OCT enables to detect airway wall structures and remodelling, including changes in the airway smooth muscle and extracellular matrix.

Summary
Bronchoscopic OCT- and CLE-imaging allow high resolution imaging of airways, lung parenchyma, pleura, lung tumours and mediastinal lymph nodes. Although investigational at the moment, promising clinical applications are on the horizon.
Effect of Maintaining Immunosuppression After Kidney Allograft Failure on Mortality and Retransplantation
Authors: Balakrishnan Suryanarayanan , Smith Byron , Bentall Andrew , Kukla Aleksandra , Merzkani Massini , Stegall Mark , Schinstock Carrie 
Published: December 2022

Background.
Few studies have addressed immunosuppression management after allograft failure (AF). Immunosuppression withdrawal to minimize complications must be balanced with the risk of sensitization and potentially reduced retransplantation. We aimed to determine relationships between immunosuppression, death, sensitization, and retransplantation among patients with AF.

Methods.
We performed a single-center retrospective study of patients transplanted from October 2007 to May 2017 with AF. We collected data on demographics, immunosuppression, calculated panel reactive antibody (cPRA) levels, death, retransplantation, and dialysis. Cox regression models were used to evaluate factors associated with death and retransplantation.

Results.
From October 2007 to May 2017, 1354 solitary ABO-compatible transplants were performed, of which 97 failed. Ten percent of patients received a preemptive retransplant. Among those who returned to dialysis (n = 87), 35% died, 25% received another transplant, and 30% remained on dialysis. After AF, 46% of patients discontinued immunosuppression. The cPRA was unchanged if immunosuppression was maintained, but immunosuppression discontinuation was associated with increased cPRA from a median (interquartile range) of 18 (0–99) to 96 (88.5–100.0; P = 0.003). Age at failure (hazard ratio, 1.1; confidence interval, 1.0-1.1) and cardiovascular disease were associated with death (hazard ratio, 2.9; confidence interval, 1.2-7.0) in multivariate analysis. Importantly, immunosuppression maintenance was not associated with increased death or retransplantation despite the increase in cPRA that occurred when immunosuppression was discontinued.

Conclusions.
Kidney transplant recipients with AF have a high mortality rate after dialysis initiation. Although immunosuppression withdrawal was associated with increased cPRA, it was not associated with reduced retransplantation. Therefore, it is reasonable to discontinue immunosuppression after AF despite sensitization if retransplantation is delayed.
Anti-correlated Feature Selection Prevents False Discovery of Subpopulations in scRNAseq
Authors: Tyler Scott R , Guccione Ernesto , Schadt Eric E 
Published: December 2022

AbstractWhile sub-clustering cell-populations has become popular in single cell-omics, negative controls for this process are lacking. Popular feature-selection/clustering algorithms fail the null-dataset problem, allowing erroneous subdivisions of homogenous clusters until nearly each cell is called its own cluster. Using 45,348 scRNAseq analyses of real and synthetic datasets, we found that anti-correlated gene selection reduces or eliminates erroneous subdivisions, increases marker-gene selection efficacy, and efficiently scales to 245k cells without the need for high-performance computing.
An online reliable local trajectory planner for quadrotors
Authors: Tong Chunming , Liu Zhenbao , Zhao Wen , Wang Baodong , Cheng Yao , Wang Jingyan 
Published: December 2022

Purpose
This paper aims to propose an online local trajectory planner for safe and fast trajectory generation that combines the jerk-limited trajectory (JLT) generation algorithm and the particle swarm optimization (PSO) algorithm. A trajectory switching algorithm is proposed to improve the trajectory tracking performance. The proposed system generates smooth and safe flight trajectories online for quadrotors.

Design/methodology/approach
First, the PSO algorithm method can obtain the optimal set of target points near the path points obtained by the global path searching. The JLT generation algorithm generates multiple trajectories from the current position to the target points that conform to the kinetic constraints. Then, the generated multiple trajectories are evaluated to pick the obstacle-free trajectory with the least cost. A trajectory switching strategy is proposed to switch the unmanned aerial vehicle (UAV) to a new trajectory before the UAV reaches the last hovering state of the current trajectory, so that the UAV can fly smoothly and quickly.

Findings
The feasibility of the designed system is validated through online flight experiments in indoor environments with obstacles.

Practical implications
The proposed trajectory planning system is integrated into a quadrotor platform. It is easily implementable onboard and computationally efficient.

Originality/value
The proposed local planner for trajectory generation and evaluation combines PSO and JLT generation algorithms. The proposed method can provide a collision-free and continuous trajectory, significantly reducing the required computing resources. The PSO algorithm locally searches for feasible target points near the global waypoint obtained by the global path search. The JLT generation algorithm generates trajectories from the current state toward each point contained by the target point set. The proposed trajectory switching strategy can avoid unnecessary hovering states in flight and ensure a continuous and safe flight trajectory. It is especially suitable for micro quadrotors with a small payload and limited onboard computing power.
From house to home: exploring the spatial expression of social identity on traditional Shiraz houses
Authors: Moqadam Sadrodin , Nubani Linda 
Published: December 2022

PurposeThe present study, based on a comparative analysis of several historic houses in Shiraz, presents a new perspective on uncovering the role of the social lives of homeowners in the formation of the spatial configurations of their houses.Design/methodology/approachTwelve plans were selected and analyzed using space syntax techniques. The spatial characteristics were compared mathematically using integration, intelligibility and axial synergy.FindingsThe results of the research showed that spatial configurations reflected the social identity of their homeowners as well as their cultural and private beliefs. The results further highlighted the syntactical differences between different types of one courtyard houses, two courtyard houses and three courtyard houses. While privacy was maintained across all housing layouts, centralized one-courtyard typography had the highest synergy while the three-courtyard typology had the highest intelligibility.Originality/valueThis research advances the use of space syntax approach in the design of contemporary housing by recognizing the socio-cultural values of its occupants.
How to encourage students continue learning English on podcast? The perspectives of stimulus-organism-response and interest driven creator theory
Authors: Chen Min Ching , Chan Tak-Wai , Chen Yu Hsin 
Published: December 2022

Purpose
Podcasting is a new mobile technology application for language learning. Drawing upon the stimulus–organism–response model and the interest driven creator (IDC) theory from e-learning, this study aims to develop and test an integrative conceptual framework. This study investigates contextual and environmental stimuli effects (content richness [CR], self-directed learning [SDL] and situational interest [SI]) from a podcast English learning context on learners’ experience states (cognitive absorption [CA], pleasure [PL] and arousal [AR]) and their subsequent responses (continuance learning intention [CLI]).

Design/methodology/approach
Using 416 valid responses from five universities located in North Taiwan, data analysis is performed using a structural equation model.

Findings
The results show that most of the interest factor stimuli (CR, SDL and SI) have significant impacts on learners’ experiences (CA, PL and AR), which in turn affect their CLI.

Practical implications
The findings provide useful insights for English show podcasters and operators to invest in establishing learners’ interest factor and stimulating experiences to improve their CLI.

Originality/value
This paper contributes to a better understanding of students who use contextual factors of podcast English learning and how these factors influence their CLI via a framework of stimulus–organism–response and the IDC theory.
The relationship between management control systems and innovativeness in start-ups: evidence for product, business model, and ambidextrous innovation
Authors: Endenich Christoph , Lachmann Maik , Schachel Hanna , Zajkowska Joanna 
Published: December 2022

Purpose
This paper aims to analyze the relationship between the use of management control systems (MCSs) and innovativeness in start-ups pursuing product innovation (PI), business model innovation (BMI) or ambidextrous innovation (both PI and BMI ).

Design/methodology/approach
This paper reports on survey data collected at 143 European start-ups using a structured questionnaire sent to a member of the top management team at each firm.

Findings
The authors find that the control levers and their interdependencies associated with increased innovativeness significantly differ between the different forms of innovation.

Practical implications
The study provides important guidance for entrepreneurs so that they can effectively support their innovation agenda with the MCSs tailored to their needs.

Originality/value
This research contributes to a growing literature that shows the positive role of MCSs in innovative and entrepreneurial processes. It adds to the understanding of the multifaceted nature of innovation and the crucial importance of BMI and ambidextrous innovation for the success of start-ups.
Using gay models in mainstream media: an expanded match-up hypothesis perspective
Authors: Chinchanachokchai Sydney , Hanson-Rasmussen Nancy , Faber Ronald J. 
Published: December 2022

Purpose
To be successful, brands should incorporate diversity in their advertising strategy. One way is to demonstrate their support for the LGBTQI community in mainstream media. This study aims to examine situational factors that affect the responses to gay presenters in mainstream media.

Design/methodology/approach
Two experimental studies were conducted in a 2 (luxury vs value brand) × 2 (gay vs heterosexual presenters) between-subjects design. Study 1 explores the interaction effects, whereas Study 2 introduces perceived congruence between the presenters and the product as a mediator.

Findings
The results show that using gay presenters in luxury brand ads leads to a more positive attitude toward the advertisement and higher product evaluation than using heterosexual presenters, whereas using heterosexual presenters to represent a value brand leads to a higher attitude and product evaluation than using gay presenters.

Practical implications
Nowadays, there is a greater need for inclusiveness and diversity in advertising. Brands need to pay attention to various underrepresented groups and adapt their strategy accordingly. This study shows that in appropriate situations, gay presenters can improve the image of a brand among heterosexual as well as gay consumers.

Originality/value
Expanding the match-up hypothesis theory, this work shows that a match can include not just an individual endorser but also the social category the endorser represents and stereotypical beliefs associated with that group.
Fraud detection using fraud triangle theory: evidence from China
Authors: Rahman Md Jahidur , Jie Xu 
Published: December 2022

Purpose
This study aims to explore the relationship between fraud triangle theory (FTT) and the accounting fraud phenomenon in all listed companies in China.

Design/methodology/approach
The CSMAR database is used as the sample, including 16,063 data of all listed companies in Shanghai and Shenzhen markets for the 2010–2020 period. The authors also use quantitative methods, such as regression analysis, to investigate the relationship between five variables (cover three elements of FTT) and fraud occurrence.

Findings
Results show that leverage and liquidity ratios positively affect fraud detection, whereas return on net equity, audit size and independent director percentage negatively affect fraud detection.

Originality/value
This study enriches theoretical research on the causes of accounting fraud in China and is of great significance to the sound development of China’s capital market.
Understanding knowledge transfer and knowledge management through social learning
Authors: Ting Ding Hooi 
Published: December 2022

Purpose
Using social learning theory and the model of innovation diffusion, this study aims to provide reflections on how new information and knowledge can be shared and adopted by farmers in collectivist rural areas.

Design/methodology/approach
Firstly, the researcher selected 76 farmers from four rural villages in Perak, Malaysia, and, using semi-structured, probing interviews, explored the underlying factors that contribute to information and knowledge transfer. Secondly, the researcher analysed 452 questionnaires to validate the qualitative interview findings. Thirdly, the researcher analysed 487 questionnaires after nine months to determine whether differences had occurred in knowledge acceptance and adoption.

Findings
Social learning and local integration play prevalent roles in information and knowledge spread among individuals. However, the data also suggest that care must be taken to ensure that the knowledge spread does not jeopardise the prevailing collective structure; rather, it must begin with innovators who show evidence of improved yield.

Practical implications
The findings suggest strategies for researchers and practitioners to transfer knowledge to farming communities using innovators and the social learning process.

Social implications
Members of a collectivist society often find it difficult to deviate from the norm; therefore, understanding how local integration, sequencing of information and knowledge spread can be accomplished through proper protocols and ethics is important.

Originality/value
While prior research has produced insights into knowledge management among individuals, the field still lacks a comprehensive understanding of the germinal stages of how individuals initiate norm-breaking behaviour while continuing to adhere to societal norms.
When should bees be flower constant? An agent‐based model highlights the importance of social information and foraging conditions
Authors: Hayes Lucy , Grüter Christoph 
Published: December 2022

Abstract

Many bee species show flower constancy, that is, a tendency to visit flowers of one type during a foraging trip. Flower constancy is important for plant reproduction, but the benefits of constancy to bees is unclear. Social bees, which often use communication about food sources, show particularly strong flower constancy.

We aimed to better understand the benefits of flower constancy in social bees and how these benefits depend on foraging conditions. We hypothesised that sharing social information increases the benefits of flower constancy because social foragers share information selectively about high‐quality food sources, thereby reducing the need to sample alternatives.

We developed an agent‐based model that allowed us to simulate bee colonies with and without communication and flower constancy in different foraging environments. By varying key environmental parameters, such as food source numbers and reward size, we explored how the costs and benefits of flower constancy depend on the foraging landscape.

Flower constancy alone performed poorly in all environments, while indiscriminate flower choice was often the most successful strategy. However, communication improved the performance of flower constant colonies considerably in most environments. This combination was particularly successful when high‐quality food sources were abundant and competition was weak.

Our findings help explain why social bees tend to be more flower constant than solitary bees and suggest that flower constancy can be an adaptive strategy in social bees. Simulations suggest that anthropogenic changes of foraging landscapes will have different effects on the foraging performance of bees that vary in flower constancy.
Kinetic modulation of bacterial hydrolases by microbial community structure in coastal waters
Authors: Abad Naiara , Uranga Ainhoa , Ayo Begoña , Arrieta Jesús Maria , Baña Zuriñe , Azúa Iñigo , Artolozaga Itxaso , Iriberri Juan , González‐Rojí Santos J. , Unanue Marian 
Published: December 2022

AbstractIn this study, we hypothesized that shifts in the kinetic parameters of extracellular hydrolytic enzymes may occur as a consequence of seasonal environmental disturbances and would reflect the level of adaptation of the bacterial community to the organic matter of the ecosystem. We measured the activities of enzymes that play a key role in the bacterial growth (leucine aminopeptidase, β‐ and α‐glucosidases) in surface coastal waters of the Eastern Cantabrian Sea and determined their kinetic parameters by computing kinetic models of distinct complexity. Our results revealed the existence of two clearly distinct enzymatic systems operating at different substrate concentrations: a high‐affinity system prevailing at low substrate concentrations and a low‐affinity system characteristic of high substrate concentrations. These findings could be the result of distinct functional bacterial assemblages growing concurrently under sharp gradients of high‐molecular‐weight compounds. We constructed an ecological network based on contemporaneous and time‐delayed correlations to explore the associations between the kinetic parameters and the environmental variables. The analysis revealed that the recurring phytoplankton blooms registered throughout the seasonal cycle trigger the wax and wane of those members of the bacterial community able to synthesize and secrete specific enzymes.