bluuebunny/crossref_metadata_2025_split huggingface dataset:
Freshwater contribution along Irish coastal areas: chemical data and geological aspects
Authors: Guerra Maria Teresa 
Published: September 2022

Abstract
Open ocean carbonate chemistry is altered by the dissolution of atmospheric CO2 in seawater. Up to 40% of anthropogenic CO2 emissions have been dissolved in the surface ocean, driving changes in the marine carbonate system and promoting ocean acidification. In the open ocean Total Alkalinity (TA) shows strong correlation with salinity and temperature due to the conservative nature of its constituents there. However, in coastal areas the interaction with the continent makes these relations much more complex. Freshwater inputs can provide an additional source of TA and Dissolved Inorganic Carbon (DIC) to the coast or lower them through dilution. The aim of this study is to understand the impact of land-ocean interactions over the coastal carbonate system and therefore, over local ocean acidification processes. The Marine Institute has provided a large dataset with several surveys along the Irish coastline, from 2009 to 2018, measuring TA, DIC and nutrients (nitrate NO3−, nitrite NO2−, phosphate PO43− and silicate SiO4−). In order to understand whether the watershed geology or the land-usage can influence the coastal chemistry, the original dataset was at first reduced to have a set of variables comparable in different locations. Principal Component Analysis (PCA) was then performed. Contrasting continental influence over the coastal carbonate system was observed, which was related to the geology of the catchment area. Elucidating how land-ocean interactions affect the coastal carbonate system would help to understand coastal resilience to ocean acidification and thus support better management of coastal resources.
Risk of Autism Spectrum Disorder according to the dose and trimester of Exposure to Antiseizure Medications: A Systematic Review and Meta-analysis
Authors: Mohamed Zakaria Ahmed , Thokerunga Erick , Jimale Ali Omar , Liu Zhichen , Fan Jingyi 
Published: September 2022

Abstract
Background
The association between prenatal exposure to antiseizure medications (ASM) and autism spectrum disorder has been documented. This study sought to examine and synthesize evidence from studies that have evaluated these associations, with particular focus on the trimester of pregnancy and dosage of exposure.
Methods
PubMed, Embase, and PsycINFO databases were searched following strict inclusion/exclusion criteria. 10 studies were recruited involving children born to mothers with epilepsy who took ASM during pregnancy as cases, and those with epilepsy who did not take any ASM in pregnanc.
Results
The relative risk of developing ASD among children exposed to valproic acid (RR, 3.90 [95% CI: 2.36–6.44]), was twice higher than that of carbamazepine (RR, 1.65 [95% CI: 0.62–4.37]), or lamotrigine (RR, 1.60 [95% CI: 0.77–3.32]) The trimester of exposure and dosage of ASM administered were inconsistent.
Conclusion
In summary, prenatal exposure to ASM increased the risk of developing ASD in children. The relative risk was twice as high in those exposed to valproic acid compared to those exposed to carbamazepine or lamotrigine. Trimester of pregnancy and dosage of ASM used by the mothers were not consistent .
Effects of microfluidization on the physical and storage stability of walnut protein emulsion and beverages
Authors: Ling Yuxi , Cheng Le , Bai Xue , Chang Min , Shen Yehua , Li Cong , Ren DiFeng 
Published: September 2022

Abstract
Walnut meal is a by-product produced during the production of walnut oil and is often treated as a waste. However, the nutrients in walnut meal mean it has significant potential for development as a plant-based milk. This study investigated the effect of microfluidization on the stability of walnut protein emulsion (WPE) and walnut protein beverage (WPB) produced from walnut meal, compared with conventional homogenization. The particle size, zeta potential, rheological properties, and stability of WPE all significantly improved after microfluidization. The mean particle size and zeta potential of the microfluidized WPE significantly decreased (p < 0.05). The rheological properties demonstrated that the viscosity of the microfluidized WPE decreased by 80%, and that the shear force increased 4.5 times as the shear rate increased. This gave the resulting product the characteristics of non-Newtonian fluid. LUMisizer stability demonstrated that microfluidization improves stability through protein absorption on the oil-water interface. Microfluidization increased the denaturation temperature (Tm) of WPE from 135.65℃ to 154.87℃. Moreover, microfluidization improved the color, centrifugal precipitation rate, and viscosity in WPB compared to the control at all studied temperatures. The Arrhenius approach was used to establish a shelf-life model, which predicted that microfluidized WPB could be stored for 175 d at 4℃.
Sevoflurane postconditioning ameliorates cerebral ischemia-reperfusion injury in rats via TLR4/MyD88/TRAF6 signaling pathway
Authors: Zhao Zijun , Li Yishuai , Chi Fei , Ma Li , Li Yanan , Wang Qiujun 
Published: September 2022

Abstract
To determine whether sevoflurane postconditioning protects against cerebral ischemia reperfusion (I/R) injury and its potential underlying mechanism, we employed bioinformatics, functional enrichment analysis, gene set enrichment analysis, neurological assessments, and western blot analysis, as well as triphenyl tetrazolium chloride, hematoxylin and eosin, Nissl, and immunofluorescence staining. We identified 103 differentially expressed genes induced by cerebral I/R, including 75 upregulated genes and 28 downregulated genes enriched for certain biological processes (involving regulation of inflammatory responses, cellular responses to interleukin 1, and chemokine activity) and signaling pathways (such as transcriptional misregulation in cancer, interleukin-17 signaling, rheumatoid arthritis, MAPK signaling, and Toll-like receptor signaling). Cerebral I/R-induced neurological deficits were comparatively less severe following sevoflurane postconditioning. In addition, TLR4/MyD88/TRAF6 signaling pathway-related proteins and neuropathic damage were ameliorated in aged rats following sevoflurane postconditioning, while the TLR4 agonist lipopolysaccharide aggravated these changes. Together, these findings suggest that sevoflurane postconditioning ameliorates cerebral I/R injury by a mechanism involving inhibition of the TLR4/MyD88/TRAF6 signaling pathway to suppress neuroinflammatory responses.
An Unusual Presentation of Paediatric Lupus Nephritis - Case Report
Authors: Singh Raashi , Jain Shruti , Sharma Shobha , Gupta Kanishk , Batra Vineeta , Gera Rani 
Published: September 2022

Abstract
Introduction : Systemic lupus erythematosus (SLE), a chronic autoimmune disease is characterized by periods of remissions and flares. Paediatric systemic lupus erythematosus (pSLE) is uncommon with majority diagnosed in adolescent age group and has more severe presentation specially involving kidneys. Kidney involvement primarily manifests as hematuria, proteinuria with varying kidney dysfunction and histologically presents as glomerulonephritis with associated tubulo-interstitial involvement. Predominant or isolated interstitial tubulo-nephritis without glomerulopathy is rare and reported in few cases. Also, the most common pulmonary presentation is pleurisy in SLE. Pneumothorax is rarely seen.
Case presentation : Here, we report a 10 years old female presenting with prolonged fever diagnosed as SLE later developing proteinuria with histology suggestive of isolated tubulo-interstitial nephritis. She had complicated course with recurrent pneumothorax and subsequent CNS tuberculosis(TB). Careful and regular monitoring of the case led to eventual improvement and remission.
Conclusion : Pediatric SLE is a serious illness with multi-systemic involvement and difficult course, therefore warrants close monitoring and active surveillance.
Study on pickling technology to control fouling of ceramic membrane treating secondary treated effluent
Authors: Wang Fengchao , Zhang Shoubin , Jiao Wenhai , Chen Jingying , Zhao Shikai , Ma Guoqiang , Liu Guicai 
Published: September 2022

Abstract
The application of membrane technology in the field of water treatment was increasingly widespread, but membrane fouling still restricted its development, and the membrane needed to be chemically cleaned. This research focused on the high-efficiency pickling technology of ceramic membrane, and developed the cleaning technology of ceramic membrane in cooperation with surfactant. In the experiment, the municipal secondary effluent was used as the raw water, and the single-step, mixed and step-by-step cleaning effects of three strong acids, three weak acids and surfactants on ceramic membranes and polyvinylidene difluoride (PVDF) membranes were investigated. For ceramic membrane, the optimal cleaning combination was H2SO4 first and then DTAC, and the flux recovery rate could reach 96.94%; for PVDF membrane, the optimal cleaning combination was HNO3 first and then H2SO4, and the flux recovery rate could reach 93.72%. In addition, the surface of initial, polluted, and cleaned membranes were analyzed by scanning electron microscope and contact angle, and the fouling mechanism of the ceramic membrane was analyzed. The results showed that through physical cleaning and chemical cleaning, most of the pollutants on the membrane surface and pores were removed. The cleaning method can effectively control the membrane pollution.
Ancient Wheat as Promising Nutraceuticals for the Prevention of
Chronic and Degenerative Diseases
Authors: Basile Giovanna , De Maio Azzurra Chiara , Catalano Alessia , Ceramella Jessica , Iacopetta Domenico , Bonofiglio Daniela , Saturnino Carmela , Sinicropi Maria Stefania 
Published: September 2022

Abstract:
In the context of a balanced diet, wheat, mainly used as whole grains, is a
good source of nutrients, including fibers and bioactive compounds. Cereals belong to
the Poaceae family and are crucial for maintaining a healthy status, granted by their nutritional
and chemical properties. Recent studies have demonstrated that the intake of
whole grains and grain-based products may reduce the risk of oxidative stress, thus lowering
chronic and age-related disorders, such as obesity, cardiovascular diseases, type II diabetes
and cancer. Indeed, several studies report that regular whole grain consumption is
associated with lower levels of total and LDL-cholesterol, triglycerides, fasting glucose,
blood pressure and body mass index. Moreover, ancient wheat species have become increasingly
interested in human health, containing several nutraceutical compounds, such
as vitamins and minerals. The numerous phytochemicals present in ancient wheat (polyphenols,
carotenoids, phytosterols and phenolic compounds) provide, in fact, antioxidant
properties, which are essential in the prevention of various chronic and degenerative
diseases. This review aims to report information on ancient wheat species, discussing
their composition and nutraceutical properties compared with modern varieties and highlighting
the beneficial impact on human health.
Medicinal Prospects of Targeting Tyrosinase: A Feature Review
Authors: Wang Yuanyuan , Xiong Baichen , Xing Shuaishuai , Chen Ying , Liao Qinghong , Mo Jun , Chen Yao , Li Qi , Sun Haopeng 
Published: September 2022

Abstract:
Tyrosinase is a bifunctional polyphenol oxidase (PPO), catalyzing two oxidative reactions: monophenols to o-quinones (monophenolase activity) and o-diphenols to o-quinones (diphenolase activity). As tyrosinase is the rate-limiting enzyme for the melanogenesis process, it is an attractive target for melanogenesis inhibition. Aiming at skin whitening, anticancer, Parkinson’s disease (PD) treatment, antibacterial, fruit and vegetable preservation and other anti-pigmentation effect, medicinal chemists have exploited diverse tyrosinase inhibitors through various approaches. In addition to discovering inhibitors with novel scaffold, good activity and high safety, researchers also focused on developing strategies for synergistic effects of multiple inhibitors and simultaneously regulating multiple targets to treat cancer or neurodegenerative diseases. This review focused on multiple natural and synthetic tyrosinase inhibitors which could contribute to preventing fruit and vegetable browning, skin whitening, antibacterial, anticancer, Parkinson's Disease etc.
Synthesis, Molecular Docking and ADME-TOX Studies of New Tacrine Analogs as
Promising for Alzheimer's Disease Therapy
Authors: Baba-Ahmed Ikram , Kibou Zahira , Daoud Ismail , Belhadj Fatima , Lahcen Belarbi , Daich Adam , Choukchou-Braham Noureddine 
Published: September 2022

Abstract:
The modification of drug delivery routes can be used as a promising strategy to improve the therapeutic profile of various drug agents. Herein, the synthesis and molecular modeling of a series of 6,7,8,9-tetrahydrobenzo [b] [1,8] naphthyridines derivatives were reported to explore potent and less toxic scaffolds. The tacrine analogs 6–10 were obtained by an efficient strategy using Friedlander's condensation between 2-aminopyridine-3-carbonitriles 1–5 and cyclohexanone under microwave irradiations without catalysts and solvents. The synthesized compounds were identified through 1H NMR, 13C NMR, IR. Their inhibition activities against acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) were focused as probable drug targets for Alzheimer’s disease (AD). The pharmaco-kinetic properties, the risk of probable hepato-toxic metabolites, and the toxicological properties were predicted using computational methods. The prediction of the toxicity risks via the GUSAR software allowed us to resolve the best approach for drug delivery, namely the subcutaneous, intravenous, or oral route., Also, the GUSAR software was used to reveal all possible adverse effects. All these techniques were tested for the L1-6 compounds by choosing tacrine as a template compound. Among these compounds, the optimal compound L1 was the most potent inhibitor and had the best score binding affinity compared to the reference drug (Tacrine) -7.926 and -7.007 kcal/mol for AChE and BuChE, respectively. Moreover, this same compound presented a satisfying pharmaceutical profile. In the present study, subcutaneous delivery is considered a promising administration of reference drug and their derivatives against AD.
The Role of Gut Microbiota in Inflammatory Bowel Disease-Current State
of the Art
Authors: Safarpour Ali Reza , Askari Hassan , Shojaei-Zarghani Sara , Raeis-Abdollahi Ehsan , Jahromi Hossein Kargar , Abdullahi ‪Payman Raise , Daliri Karim , Tajbakhsh Amir , Rahmati Leila 
Published: September 2022

Abstract:
The human microbiome comprises the genomes of the microbiota that live on and within
humans, such as protozoa, archaea, eukaryotes, viruses, and most bacteria. Gastrointestinal disorders
such as inflammatory bowel disease, colon cancer, celiac disease, and irritable bowel syndrome can
all be triggered by a change in gut flora. The alteration of the gut microbiota (also known as "gut
dysbiosis") is affected by host genetics, nutrition, antibiotics, and inflammation, and it is associated
with the development of inflammatory bowel disease (IBD). Also, intestinal epithelial dysfunction,
altered autophagy, and immune hyperactivation are frequently detected in individuals with severe
IBD, which may be attributed to impaired miRNA expression functions. While the exact mechanisms
of how Gut Microbiota may cause IBD and intestinal epithelial dysfunction are still debated, recent
data point toward the possibility that hormones, gender and miRNAs expression are modifiable contributors
to IBD. This review summarizes the current evidence for an association between hormones,
gender and miRNAs and Gut Microbiota in IBD and discusses potential mechanisms by which gut
microbiota may impact IBD. The study also outlines critical unanswered topics that need to be solved
to enhance IBD prevention and treatment in people with gut dysbiosis.
Docking Study on Caspase 3 Inhibitors As Potential Drugs For Traumatic
Brain Cell Apoptosis
Authors: Najafi Sajad , Alibakhshi Abbas , Mahnam Karim , Ranjbari Javad 
Published: September 2022

Background:
Apoptosis of brain cells (neurons and glia) has a crucial role in humans' pathology
of traumatic brain injury (TBI). So, a decrease in the apoptosis rate can potentially reduce the harmful
effects and lead to better functional outcomes. Drug repurposing by computational methodologies like
protein-ligand docking allows us to make drug discovery more efficient and less expensive.

Objective:
In the current study, we used the methodology to study the inhibitory effect of thousands of
FDA/non-FDA approved, investigational compounds on caspase 3 as one of the most important members
of the cell apoptosis pathway.

Methods:
Molecular docking and pharmacokinetic properties calculations were done. The molecular dynamics
(MD) simulations of all complexes and free caspase 3 were carried out. We carried out docking
experiments using in silico methods and docked a pool of medications to the active site of the human
caspase-3 X-ray structure. The best compounds were selected and subjected to pharmacokinetic analysis,
molecular simulation, and free energy calculations.

Results:
Finally, 6 components (Naldemedine, Celastrol, Nilotinib, Drospirenone, Lumacaftor, and R-
343) were selected as the best in terms of structural and pharmaceutical properties, low toxicity that can
be administered orally for the preclinical and clinical future investigations.
Pinpoint and Stewardship of Psoriasis by Using Phytoconstituent-based
Novel Formulation
Authors: Qadir Abdul , Gupta Dipak Kumar , Mir Najib Ullah Shehla Nasar , Aqil Mohd. , Jahan Samreen , Khan Nausheen 
Published: September 2022

Abstract:
Psoriasis is an autoimmune skin condition that is also inflammatory and proliferative. Psoriasis is caused by activation of T-cells and is distinguished by prominent, drab-red, or peach-pink tight patches with silvery scales on the skin. In recent years, there have been some significant advances in the study of the etiology of inflammatory skin diseases such as psoriasis. The nanotechnology-based novel formulation provides a great occasion for enhancing the efficacy and safety of pharmacotherapeutic agents for psoriasis. The benefits of nanotechnological techniques to offer an effective drug concentration in the disease site and nanocarrier as innovative possibilities for drug delivery systems in psoriasis and other inflammatory chronic skin disorder are highlighted in this area. We have explored the mechanisms underlying the pathogenic aspects of psoriasis in this review, as well as phytoconstituents, naturally occurring substances found in plants with anti-psoriatic properties. Anti-psoriatic action is attributed to phytochemicals that target cytokine signaling pathways. We also discussed the benefits of loading phytoconstituents as drugs in nanocarriers such as liposomes, niosomes, invasomes, phytosomes, transferosomes, and pro-niosomes for improved topical therapy and delivery of phytoconstituents with a better therapeutic profile and lower toxicity.
Assessment of Effect of Intra-pocket Delivery of Metronidazole Loaded NTrimethyl Quaternary Ammonium Chitosan Nanoparticles in Treatment of Periodontal Disease
Authors: Garg Kritika , Tirgar Pravin 
Published: September 2022

Background:Conventional drugs like metronidazole for periodontitis has shown several drawbacks. So based on in-vitro and acute toxicity study of metronidazole loaded n-trimethyl quaternary ammonium chitosan nanoparticles (NTMET NPs), animal studies was carried out to proof enhancement of activities over periodontitis.Objectives:To assess the effect of nanoparticles through an intra-pocket drug delivery on body weight, food consumption, clinical signs, gingival index, tooth mobility, inflammatory changes in periodontal tissues, and serum analysis that leads into gingival damage, connective tissues and alveolar bone resorption.Method:P. gingivalis and ligature induced periodontitis model was used to evaluate the effect of drug in rats.Results:periodontitis was successfully induced by using P. gingivalis and ligature induced periodontitis model in rats. It reflect elevated gingival index, tooth mobility, inflammatory changes in tissues, IL-6, TNF- ɑ, and IL -1β when compared to control group and NTMET NPs treated groups. It was also observed that the damage caused to gingival tissues and resorption of alveolar bone was improved by using NTMET NPs.Conclusion:Based on present findings, we can conclude that NTMET NPs at a dose of 1.8 & 3.6 mg/ml has significant action on periodontal tissues and was able to reverse the effect of P. gingivalis as well as gingival damage and tooth mobility in rats at an administered dose, which are comparable to the IC50 value of a drug. The findings of the current study provide scientific preclinical data to support its clinical use for periodontitis via intra pocket drug delivery route.
An In-depth Analysis of Majoon Zabeeb, an Enduring Polyherbal Unani
Formulation for Epilepsy
Authors: Zakir Mohammad , Alam Md. Aftab , Khatoon Faiza , Ahmad Waish , Minhajuddin Ahmed 
Published: September 2022

Abstract:
Unani Medicine System is one of the oldest systems with its potent and effective drugs from animal, plant, and mineral sources. Over 2400 years ago, Hippocrates, the founder of medicine, practiced it; however, his medicine includes many ancient Egyptian medications and important components of ancient Mesopotamian customs and traditions. Neurological problems are a significant cause of death, comprising 12% of all deaths globally. Sar' is used for epilepsy in USM, which means falling. Convulsions occur after the patient has fallen due to partial occlusion in the passage of Rūh Nafsānī (psychic pneuma).
A vast number of single and multi-ingredient medicines were referenced for epilepsy treatment. Majoon Zabeeb (MZ) is possibly the most presumed polyherbal preparation used in epilepsy. This polyherbal compound has eight components used as a strong anticonvulsant, antispasmodic, antioxidant, deobstruent, memory enhancer, neuroprotective, nervine tonic, and anti-inflammatory agent.
Performance Analysis of Hybrid PV-Diesel Generator with Energy Storage
System in South Sinai, Egypt
Authors: Fawy Abdelrahman , El Masry Said E. , Abo Adma Maged A. , Kandil Shaimaa A. 
Published: September 2022

Background:
Renewable energy systems are the most promising long-term sustainable
energylong-term sustainable energy, with numerous advantages. Renewable energy systems that
combine traditional and renewable resources are now cost-effective and have a low carbon impact.
These systems are becoming more popular as a feasible option for rural areas, particularly
when it comes to grid connectivity.

Objective:
This study discusses the ideal design and size for separated PV batteries and dieselbased
renewable energy systems. South Sinai, Egypt, was chosen as the testing location for unusual
environmental conditions, system specs, and daily energy requirement statistics to analyze
the total energy required for a specific site. The load under investigation is a school complex in
one of the governorate's cities.

Method:
The complete system is simulated and tested using the MATLAB/Simulink program.

Results:
In this study the amount of energy required by the load is determined. The load power is
compared with the system output power to justify the reliability of the system. The system output
voltage is shown which is sinusoidal wave. The management control system between PV, diesel
and battery is shown

Conclusion:
The results show that the system is reliable; the control strategies always indicate the
load requirement and minimize the diesel run time.