bluuebunny/crossref_metadata_2025_split huggingface dataset:
Finding Your Calling
Authors: Petersen Cheryl L. , Munk Dennis D. , Dalton Daniel 
Published: September 2022

ABSTRACT:
The aim of this study was to assess if an evidence-based educational program focused on vocation and calling could improve undergraduate nursing students' sense of meaning in life and sense of calling/vocation. Using a mixed-methods, quasi-experimental design, a statistically significant increase occurred in sense of meaning in life and calling/vocation. Qualitative responses revealed growth in self-knowledge, importance of individual pathways, and recognition of nursing as one's calling. Courses on calling may encourage nursing students to commit to nursing as a calling.
Piloting a Faith-Based Hypertension Self-Care Program in a Church Setting
Authors: Alen Josiya , Forehand Jeffery , Miller Barbara 
Published: September 2022

ABSTRACT:
Health promotion strategies offered in a faith-based setting can be effective in influencing positive self-care behaviors related to hypertension. Faith-based organizations are ideal places to reach vulnerable populations to improve blood pressure management and make a lasting impact. The purpose of this pilot study was to provide a 4-week management program to improve hypertension self-care among a congregation of African Americans. Results revealed improvements among participants related to self-care as well as lowered blood pressure readings.
Considerations in Limiting Abortion
Authors: Hammons Kati E. 
Published: September 2022

ABSTRACT:
In May 2021, Texas passed Senate Bill Eight, the Texas Heartbeat Act. The act bans physicians from performing an abortion after a fetal heartbeat is detected and bans nonmedical people from aiding or abetting an abortion in such situations. The act has significant social, economic, political, and ethical impacts for women with unintended pregnancies, for the state of Texas, and for nurses and other providers. A Christian perspective is offered regarding life, abortion, and the need to provide special care and support for women in crisis pregnancies.
Pain interference in young adulthood and work participation
Authors: Pooleri Anand , Yeduri Rishita , Horne Gabrielle , Frech Adrianne , Tumin Dmitry 
Published: September 2022

Abstract
Chronic pain is associated with reduced work participation, but longitudinal data on the work impact of chronic pain are limited. We used data from the National Longitudinal Survey of Youth-1997 cohort to analyze how pain interference in early adulthood was associated with subsequent exit from the labor force in a longitudinal survey. Pain interference at age 29 and employment status were self-reported at subsequent biennial interviews. Exit from the labor force, return to employment, and development of new health-related work limitations after age 29 were analyzed using survival analysis methods. Among 5819 respondents, 10% and 3% endorsed “a little” or “a lot” of pain interference at age 29, respectively. During follow-up (median of 26 months until censoring or labor force exit), 43% of respondents had exited the labor force at least once and 10% developed a new work-related health limitation. The highest pain interference group (compared with no pain interference) had higher hazard of labor force exit (hazard ratio: 1.26; 95% confidence interval: 1.01-1.57; P = 0.044) and of developing new health-related work limitations (hazard ratio: 2.45; 95% confidence interval: 1.64-3.67; P < 0.001), with similar results for the group experiencing “a little” pain interference at age 29. In this nationally representative cohort, any level of pain interference reported at age 29 was found to predict increased hazards of subsequent labor force exit and health-related work limitation. Early identification and treatment of pain problems among young workers can help reduce burdens of future unemployment and disability.
Cochlear Implantation Outcomes in Patients With Retrocochlear Pathology: A Systematic Review and Pooled Analysis
Authors: Schlacter Jamie A. , Kay-Rivest Emily , Nicholson Joseph , Santacatterina Michele , Zhang Yan , Jethanamest Daniel , Friedmann David R. , McMenomey Sean O. , Roland J. Thomas 
Published: September 2022

Objective
To review the current literature regarding cochlear implantation in patients with retrocochlear pathologies and extract speech perception scores between 6 months and 1 year after surgery.

Databases Reviewed
PubMed/MEDLINE, Embase and Cochrane CENTRAL via Ovid, CINAHL Complete via Ebsco, and Web of Science.

Methods
The review was conducted according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Search strategies included keywords and subject headings to maximize retrieval and reflect cochlear implants and retrocochlear pathologies. Patients with previously resected vestibular schwannoma (VS) were excluded.

Results
There were 2,524 abstracts screened against inclusion criteria, and 53 studies were included, with individual data available for 171 adult patients. Pathologies included were either observed or irradiated VS (previously operated tumors were excluded) (n = 99, 57.9%), superficial siderosis (n = 39, 22.8%), neurosarcoidosis (n = 11, 6.4%), and previous central nervous system or skull base radiation (n = 22, 12.9%). Mean (standard deviation) postoperative consonant-nucleus-consonant (CNC) word scores were 45.4% (24.2) for observed VS, 44.4% (20.8) for irradiated VS, 43.6% (21.0) for superficial siderosis, 89.5% (3.0) for neurosarcoidosis, and 30.0% (30.2) in patients with previous central nervous system or skull base irradiation. Irradiated compared with observed VS had similar postoperative CNC word scores (effect size, 0.06; p = 0.71). Age, sex, maximal tumor dimension, and neurofibromatosis type 2 status did not significantly impact cochlear implant performance in patients with VS. Eighty-two percent of patients with reported device usage were daily users, and overall, 82% of cases benefitted from cochlear implantation.

Conclusion
Cochlear implantation in patients with concomitant retrocochlear pathology generally results in improved speech discrimination scores sustained over time.
A Five-Year Update on the Profile of Adults Undergoing Cochlear Implant Evaluation and Surgery—Are We Doing Better?
Authors: Patro Ankita , Lindquist Nathan R. , Tawfik Kareem O. , O’Malley Matthew R. , Bennett Marc L. , Haynes David S. , Gifford René H. , Holder Jourdan T. , Perkins Elizabeth L. 
Published: September 2022

Objective
To characterize the influence of expanding indications on the profile of adults undergoing cochlear implantation (CI) at a high-volume CI center.

Study Design
Retrospective review.

Setting
Tertiary referral center.

Patients
774 adults undergoing CI evaluation from August 2015 to August 2020.

Main Outcome Measures
Demographics; audiometry; speech recognition; speech, spatial, and qualities of hearing scale (SSQ-12).

Results
Of 745 (96.3%) patients qualifying for implantation, 642 (86.6%) pursued surgery. Median age at evaluation was 69 years; 56.3% were men; 88.2% were Caucasian. Median distance to our center was 95 miles. The majority (51.8%) had public insurance (Medicare, Medicaid), followed by private (47.8%) and military (0.4%). Mean PTA, CNC, and AzBio in quiet and noise for the ear to be implanted were 85.2 dB HL, 15.0%, and 19.2% and 3.5%, respectively. Hybrid/EAS criteria were met by 138 (18.5%) CI candidates, and 436 (77.0%) unilateral CI recipients had aidable contralateral hearing for bimodal hearing configurations. Younger age (odds ratio [OR], 0.96; 95% confidence interval, 0.93–0.99) and non-Caucasian race (OR, 6.95; 95% confidence interval, 3.22–14.98) predicted candidacy. Likelihood of surgery increased for Caucasian (OR, 8.08; 95% confidence interval, 4.85–13.47) and married (OR, 2.28; 95% confidence interval, 1.50–3.47) patients and decreased for those with public insurance (OR, 0.45; 95% confidence interval, 0.29–0.69). A lower SSQ-12 score predicted both candidacy and surgery.

Conclusion
Despite expansions in criteria, speech understanding remained extremely low at CI evaluation. Younger age and non-Caucasian race predicted candidacy, and Caucasian, married patients with private insurance and lower SSQ scores were more likely to pursue surgery.
A case report of upper tibial gout stones resulting in bone destruction
Authors: Ji Jinke , Lou Caili , Ma Hongbao , Liu Jian , Wang Linan , Ren Zhibo , Yang Zongqiang , Shi Jiandang , Niu Ningkui 
Published: September 2022

Rationale:
Gout is caused by the deposition of monosodium urate crystals caused by purine metabolism disorder or uric acid excretion disorder, which could be manifested as hyperuricemia, arthritis, tophus, and even renal dysfunction and other important organ damage. Gout stones to originate from crystals formed by urate and occur to joints, ears, olecranon bursa, fingers, and tendons. Bone destruction of gout stones is rare in clinic, and is easily misdiagnosed as bone tumor, and gout stones in the upper tibia is even rarer.

Patient concerns:
A 25-year-old male patient presented with right upper tibia pain for 2 weeks without obvious cause and had no history of alcoholism or hyper purine diet.

Diagnosis:
Right tibia and fibula anteroposterior and lateral radiographs showed that a round like low-density shadow at the upper end of the right tibia. CT showed bone destruction and neoplastic lesions at the right tibial tubercle. MRI showed bone destruction at the upper end of the right tibia with local oval abnormal signal, which were considered the neoplastic lesions. However, postoperative pathological diagnosis suggested gout calculi.

Interventions:
After examination, the patient underwent surgical treatment, curettage and bone graft fusion. Long-term oral administration of uric acid lowering drug allopurinol tablets 50 mg/time, twice/day, potassium sodium hydrogen citrate particles 2.5 g/time, 3 times/day.

Outcomes:
The patient took allopurinol tablets 50 mg/time, 2 times/day and Sodium Hydrogen Citrate Granules 2.5 g/time, 3 times/day for a long time after operation. As a result, the focus on gout stones was cured. Three months after operation, the bone graft healed well, the incision healed well, and the uric acid was 397 µmol/ L, which achieved satisfactory clinical efficacy.

Conclusion:
Tibial gout stones is rare in clinic. When hyperuricemia patients have tibial bone destruction and consider bone tumor, it should be differentiated from gout stones. The blood uric acid value should be controlled to the normal range before operation, and the drug therapy of decreasing uric acid should be continued after operation.
Electronic Connectivity Among US Hospitals Treating Shared Patients
Authors: Everson Jordan , Adler-Milstein Julia 
Published: September 2022

Background:
Increasing electronic health information exchange (HIE) between provider organizations is a top policy priority that has been pursued by establishing varied types of networks.

Objectives:
To measure electronic connectivity enabled by these networks, including community, electronic health record vendor, and national HIE networks, across US hospitals weighted by the volume of shared patients and identify characteristics that predict connectivity.

Research Design:
Cross-sectional analysis of 1721 hospitals comprising 16,344 hospital pairs and 6,492,232 shared patients from 2018 CareSet Labs HOP data and national hospital surveys.

Subjects:
Pairs of US acute care hospitals that delivered care to 11 or more of the same fee-for-service Medicare beneficiaries in 2018.

Measures:
Whether a patient was treated by a pair of hospitals connected through participation in the same HIE network (“connected hospitals”) or not connected because the hospitals participated in different networks, only 1 participated, or both did not participate.

Results:
Sixty-four percent of shared patients were treated by connected hospitals. Of the remaining shared patients, 14% were treated by hospital pairs that participated in different HIE networks, 21% by pairs in which only 1 hospital participated in an HIE network, and 2% by pairs in which neither participated. Patients treated by pairs with at least 1 for-profit hospital, and by pairs located in competitive markets, were less likely to be treated by connected hospitals.

Conclusions:
While the majority of shared patients received care from connected hospitals, remaining gaps could be filled by connecting HIE networks to each other and by incentivizing certain types of hospitals that may not participate because of competitive concerns.
Development of a Berg Balance Scale Short-Form Using a Machine Learning Approach in Patients With Stroke
Authors: Wang Inga , Li Pei-Chi , Lee Shih-Chieh , Lee Ya-Chen , Wang Chun-Hou , Hsieh Ching-Lin 
Published: September 2022

Background and Purpose:The Berg Balance Scale (BBS) is frequently used in routine clinical care and research settings and has good psychometric properties. This study was conducted to develop a short form of the BBS using a machine learning approach (BBS-ML).Methods:Data of 408 individuals poststroke were extracted from a published database. The initial (ie, 4-, 5-, 6-, 7-, and 8-item) versions were constructed by selecting top-ranked items based on the feature selection algorithm in the artificial neural network model. The final version of the BBS-ML was chosen by selecting the short form that used a smaller number of items to achieve a higher predictive powerR2, a lower 95% limit of agreement (LoA), and an adequate possible scoring point (PSP). An independent sample of 226 persons with stroke was used for external validation.Results:TheR2values for the initial 4-, 5-, 6-, 7-, and 8-item short forms were 0.93, 0.95, 0.97, 0.97, and 0.97, respectively. The 95% LoAs were 14.2, 12.2, 9.7, 9.6, and 8.9, respectively. The PSPs were 25, 35, 34, 35, and 36, respectively. The 6-item version was selected as the final BBS-ML. Preliminary external validation supported its performance in an independent sample of persons with stroke (R2= 0.99, LoA = 10.6, PSP = 37).Discussion and Conclusions:The BBS-ML seems to be a promising short-form alternative to improve administrative efficiency. Future research is needed to examine the psychometric properties and clinical usage of the 6-item BBS-ML in various settings and samples.Video Abstract availablefor more insights from the authors (see the Video, Supplemental Digital Content 1, available at: http://links.lww.com/JNPT/A402).
CARDIOVASCULAR MORTALITY POST BURN INJURY
Authors: Paratz Jennifer D , Warren Jacelle , Paratz Elizabeth , Watt Kerrianne , Corte-Real Vidal , Muller Michael J , Cameron Cate M. 
Published: September 2022

ABSTRACT

BACKGROUND
Burn injury is responsible for both acute and ongoing inflammation, resulting in systematic changes impacting the cardiovascular, hepatobiliary, endocrine and metabolic systems but there is minimal investigation into long term clinical outcomes. This study aimed to investigate mortality due to cardiovascular causes long-term post burn injury.

METHODS
This was a retrospective cohort study linking a burns unit database with mortality outcomes from a Registry of Births, Deaths and Marriages. Data was extracted from the Australian Institute of Health and Welfare and stratified into three age groups: 15-44, 45-64 and 65+ years. Mortality Rate Ratios (MRR) and 95% CI were calculated to compare the burns cohort mortality incidence rates with the national mortality incidence rates the three age-groups. Logistic regression was used to identify demographic and clinical factors associated with cardiovascular mortality.

RESULTS
A total of 4134 individuals in the database were analysed according to demographic and clinical variables. The 20-year age-standardised cardiovascular mortality rate for the burns cohort was significantly higher compared to the Australian population (250.6 per 100,000 person-years (PYs) v 207.9 per 100,000 PYs) (MRR = 1.21, 95%CI 1.001-1.45). Cardiovascular mortality was significantly higher in males aged 15-44 and 45-64 years (respectively) in the burns cohort than in the age-matched Australian population (MRR = 8.48, 95%CI 3.47-13.49), and (MRR = 1.75, 95%CI 1.07-2.44) respectively. Those who died of cardiovascular disease were more frequently intubated post-burn injury (p = 0.01), admitted to intensive care (p < 0.0001), and had pre-existing comorbid physical conditions (60.9% v 15.0%, p < 0.0001).

CONCLUSION
Survivors from burn injury, especially young males are at increased long-term risk of death from cardiovascular disease. Increased screening and counselling pertaining to lifestyle factors should be standard management post burn injury. Longitudinal observation of physiological changes, investigation of mechanistic factors and investigation of interventional strategies should be instituted.

LEVEL OF EVIDENCE
Retrospective cohort study Level IV

TYPE OF STUDY
Epidemiological
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Authors: Garrett Stephen R. , Mariano Giuseppina , Palmer Tracy 
Published: September 2022

RN6390 is a commonly used laboratory strain of Staphylococcus aureus derived from NCTC8325. In this study, we sequenced the RN6390 genome and compared it to available genome sequences for NCTC8325. We confirmed that three prophages, F 11, F 12 and F 13, which are present in NCTC8325 are absent from the genome of RN6390, consistent with the successive curing events leading to the generation of this strain. However, we noted that a separate prophage is present in RN6390 that is not found in NCTC8325. Two separate genome sequences have been deposited for the parental strain, NCTC8325. Analysis revealed several differences between these sequences, in particular, between the copy number of esaG genes, which encode immunity proteins to the type VII secreted anti-bacterial toxin, EsaD. Single nucleotide polymorphisms were also detected in ribosomal RNA genes and genes encoding microbial surface components recognizing adhesive matrix molecules (MSCRAMM) between the two NCTC8325 sequences. Comparing each NCTC8325 sequence to other strains in the RN6390 lineage confirmed that sequence assembly errors in the earlier NCTC8325 sequence are the most likely explanation for most of the differences observed.
Bayesian nowcasting with Laplacian-P-splines
Authors: Sumalinab Bryan , Gressani Oswaldo , Hens Niel , Faes Christel 
Published: September 2022

AbstractDuring an epidemic, the daily number of reported infected cases, deaths or hospitalizations is often lower than the actual number due to reporting delays. Nowcasting aims to estimate the cases that have not yet been reported and combine it with the already reported cases to obtain an estimate of the daily cases. In this paper, we present a fast and flexible Bayesian approach to do nowcasting by combining P-splines and Laplace approximations. The main benefit of Laplacian-P-splines (LPS) is the flexibility and faster computation time compared to Markov chain Monte Carlo (MCMC) algorithms that are often used for Bayesian inference. In addition, it is natural to quantify the prediction uncertainty with LPS in the Bayesian framework, and hence prediction intervals are easily obtained. Model performance is assessed through simulations and the method is applied to COVID-19 mortality and incidence cases in Belgium.
Anti-Gephyrin antibodies: A novel specificity in patients with systemic sclerosis and lower bowel dysfunction
Authors: McMahan ZH , Kulkarni S , Andrade F , Perin J , Zhang C , Hooper JE , Wigley FM , Rosen A , Pasricha PJ , Casciola-Rosen L 
Published: September 2022

ABSTRACTObjectiveAutoantibodies are clinically useful in phenotyping patients with systemic sclerosis (SSc). GI function is regulated by the enteric nervous system (ENS) and commonly impaired in SSc suggesting that the SSc autoimmune response may target ENS antigens. We sought to identify novel anti-ENS autoantibodies with an aim to clinically phenotype SSc GI dysfunction.MethodsSerum from a SSc patient with GI dysfunction but without defined SSc-associated autoantibodies was used for autoantibody discovery. Immunoprecipitations performed with murine myenteric plexus lysates were on-bead digested and autoantigens were identified by mass spectrometry. Prevalence and clinical features associated with novel autoantibodies were evaluated in a SSc cohort using regression analyses. Expression of gephyrin in human GI tract tissue was examined by immunohistochemistry.ResultsWe identified gephyrin as a novel SSc autoantigen. Anti-gephyrin antibodies were present in 9% of SSc patients (16/188) and absent in healthy controls (0/46). Anti-gephyrin antibody-positive patients had higher constipation scores [1.00 vs. 0.50;p=0.02] and were more likely to have severe constipation and severe distention/bloating [46% vs. 15%;p=0.005; 54% vs. 25%;p=0.023, respectively]. Anti-gephyrin antibody levels were significantly higher among patients with severe constipation [0.04 vs. 0.00;p=0.001] and severe distention and bloating [0.03 vs. 0.004;p=0.010]. Severe constipation was associated with anti-gephyrin antibodies even in the adjusted model. Importantly, gephyrin was expressed in the ENS, which regulates gut motility.ConclusionGephyrin is a novel ENS autoantigen that is expressed in human myenteric ganglia. Anti-gephyrin autoantibodies are associated with the presence and severity of constipation in SSc patients.
Is acetazolamide a potential intervention for people with bipolar disorders? A scoping review protocol
Authors: Strawbridge Rebecca , Orfanos Stelios , Yalin Nefize , Young Allan H 
Published: September 2022

AbstractAcetazolamide is a carbonic anhydrase inhibitor whose primary indication is to alleviate altitude sickness, but it is also used in the treatment of glaucoma, seizures and oedema. Although it has not been repurposed for psychiatric illnesses, acetazolamide has been advocated for its putative benefits in those with a bipolar disorder (BD). Because current treatment options for BD bring a variety of challenges, it is important to examine the current evidence to date in a formal synthesis. This article describes a protocol for a scoping review to do so, in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for scoping reviews (PRISMA-ScR). PubMed, Embase and PsycInfo will be searched for all available publications focusing on the intervention acetazolamide for people with BD. This will include non-primary and primary research of any design, focusing on any outcome, in order to comprehensively bring together the work that has been undertaken to date on this topic. Relevant data from included articles will be subject to a narrative synthesis. It is anticipated that the results from the review will help to ascertain the potential for acetazolamide to benefit people with bipolar affective disorders in the future and aid the planning of future primary research to establish this.