bluuebunny/crossref_metadata_2025_split huggingface dataset:
Aminosäuren: Einfluss auf mentales und physisches Wohlbefinden bei Freizeitsportlern
Authors: Herbst Rabea 
Published: February 2022

ZusammenfassungEine randomisierte Doppelblindstudie mit Aminosäuren an insgesamt 38 Freizeitsportlern zeigt spannende Ergebnisse mit praktischer Relevanz im wissenschaftlichen Kontext: Entscheidend ist nicht die Menge, sondern die Qualität und Zusammensetzung der zugeführten Aminosäuren. Mit nur 8 Gramm essenziellen Aminosäuren in hydrolisierter Form konnte eine Linderung des Schmerzempfindens innerhalb von 8 Wochen Intervention erzielt werden. Damit stehen die Ergebnisse im Kontrast zu vielen Vorgängerstudien.
Diagnosis of Platelet Function Disorders: A Challenge for Laboratories
Authors: Wagner Miriam , Uzun Günalp , Bakchoul Tamam , Althaus Karina 
Published: February 2022

AbstractIn patients with normal plasmatic coagulation and bleeding tendency, platelet function defect can be assumed. Congenital platelet function defects are rare. Much more commonly they are acquired. The clinical bleeding tendency of platelet function defects is heterogeneous, which makes diagnostic approaches difficult. During the years, a large variety of tests for morphological phenotyping and functional analysis have been developed. The diagnosis of platelet function defects is based on standardized bleeding assessment tools followed by a profound morphological evaluation of the platelets. Platelet function assays like light transmission aggregation, luminoaggregometry, and impedance aggregometry followed by flow cytometry are commonly used to establish the diagnosis in these patients. Nevertheless, despite great efforts, standardization of these tests is poor and in most cases, quality control is lacking. In addition, these tests are still limited to specialized laboratories. This review summarizes the approaches to morphologic phenotyping and platelet testing in patients with suspected platelet dysfunction, beginning with a standardized bleeding score and ending with flow cytometry testing. The diagnosis of a functional defect requires a good collaboration between the laboratory and the clinician.
Naturheilkundliche Therapien bei Mikro- und Makrotraumen durch Sport
Authors: Vlachojannis Julia , Chrubasik-Hausmann Sigrun 
Published: February 2022

ZusammenfassungMikro- und Makrotraumen durch Sport gehen mit Muskelschädigung, Entzündungsreaktionen und oxidativem Stress einher. Diverse Metaanalysen evaluieren das Nutzen-Risiko-Profil von naturheilkundlichen Therapien zur verletzungsvorbeugenden Wirkung bzw. zur Beschleunigung der Regenerationsprozesse: Um Muskelkater und Müdigkeit vorzubeugen, waren Massagen wirksamer als Kompressionsverbände. Heiss-/Kaltwassertherapie inklusive Fango und Cryotherapie. Elektrostimulation, Dehnübungen und gezielte Gymnastik waren wenig wirksam.Massage und Kälteanwendungen hemmten die Entzündungsreaktionen mehr als die anderen Maßnahmen. Studien mit Laser- und Vibrationstherapie waren in der Metaanalyse nicht berücksichtigt und auch nicht die Studien zur Akupunkturbehandlung. Zu keiner der bei Mikro- und Makrotraumen durch Sport eingesetzten Therapien ist die Wirksamkeit überzeugend belegt. Konfirmatorische Studien sind dringend notwendig, damit die Methoden als Zusatz zur bedarfsangepassten, ausgewogenen Ernährung in der Sportmedizin empfohlen werden können.
Aerob-dynamisches Ausdauertraining im therapeutischen Training
Authors: Morvilius Simone 
Published: February 2022

ZusammenfassungVon planmäßigem Training profitieren Sportler jeder Disziplin, aber auch untrainierte Menschen und Patienten, da es sich in vielerlei Hinsicht positiv auf Körper und Geist auswirkt. Aerobes dynamisches Ausdauertraining bildet Grundlagenausdauer sowie einen sinnvollen Einstieg in planmäßige Bewegung. Daher ist sie als Teilaspekt der Trainingspläne vieler Sportarten integriert. Dieser Artikel zeigt Methoden und Anwendungsbeispiele der aerob-dynamischen Ausdauer und geht dabei insbesondere auf den therapeutischen und präventiven Nutzen von Ausdauertraining ein.
Die Bedeutung von Lactoferrin im Sport – am Beispiel von Amateurfußballern
Authors: Müller Artur , Gündling Peter W. 
Published: February 2022

ZusammenfassungFußball, aber potenziell auch jede andere Sportart, kann eine körperbetonte und intensive Belastung für den menschlichen Organismus darstellen. Neben sichtbaren Verletzungen wie Zerrungen, Bänderrissen oder Knochenbrüchen gibt es weitere Symptome, die latent vorhanden, aber nicht genau zuzuordnen sind. Chronische Müdigkeit, Abgeschlagenheit, rezidivierende Infektanfälligkeit, Konzentrationsstörungen und längere Regenerationszeiten werden in der Regel nicht mit der sportlichen Tätigkeit in Verbindung gebracht.Diese Symptome können auf eine Unterversorgung mit Vitalstoffen, insbesondere des Spurenelements Eisen, hinweisen.
When and How to Combine Antiplatelet and Anticoagulant Drugs?
Authors: Espinola-Klein Christine 
Published: February 2022

AbstractAntiplatelet and anticoagulant drugs work at different places in the coagulation system. Antiplatelet drugs are usually indicated in patients with atherosclerosis. Anticoagulant drugs are mostly used in patients with atrial fibrillation, venous thromboembolism, or technical heart valves. In some clinical situations, combination of antiplatelet and anticoagulant therapy can be indicated. The most recent situations are a more intensive antithrombotic therapy for risk reduction in patients with atherosclerosis and temporary addition of antiplatelet drugs in patients with indication for long-term anticoagulation. Temporary combination of antiplatelet and anticoagulant drugs is usually necessary after coronary intervention in patients with atrial fibrillation. In patients with high-risk atherosclerosis, the combination of low-dose rivaroxaban and aspirin reduces major adverse cardiovascular events (myocardial infarction, stroke, cardiovascular death) and major adverse limb events. But every combination of antiplatelet and antithrombotic drugs can increase bleeding risk. Therefore, a careful assessment of thrombotic versus bleeding risk is necessary for each patient.
Management von Thoraxdrainagen nach elektiven, thorakoskopischen,
anatomischen Lungenresektionen an thoraxchirurgischen Zentren in Deutschland .
Eine Umfrage über die Deutsche Gesellschaft für Thoraxchirurgie
(DGT)
Authors: Karampinis Ioannis , Galata Christian , Roessner Eric Dominic 
Published: February 2022

Zusammenfassung
Einleitung Die zunehmende Adaptation minimalinvasiver Techniken sowie der
Prinzipien der „Enhanced Recovery After Surgery“ (ERAS) in der Thoraxchirurgie
haben zu einer deutlichen Reduktion des perioperativen Risikos nach anatomischen
Lungenresektionen geführt. Die persistierende postoperative Luftleckage bleibt
allerdings weiterhin eine der Hauptkomplikationen. Ziel dieser Umfrage war es,
das Management von Thoraxdrainagen sowie die klinische Praxis der Behandlung
persistierender Luftleckagen nach elektiven, thorakoskopischen, anatomischen
Lungenresektionen in Deutschland zu analysieren.
Methodik Wir führten über die Deutsche Gesellschaft für Thoraxchirurgie
(DGT) eine Online-Umfrage unter thoraxchirurgischen Zentren (n = 160) in
Deutschland durch. Die Ergebnisse wurden getrennt nach High-Volume- und
Low-Volume-Zentren ausgewertet.
Ergebnisse Die Rücklaufquote betrug 35,6%. Die Mehrheit der Kliniken
verwendet als Standard eine einzelne Thoraxdrainage (24 Ch), die an ein
digitales Thoraxdrainagesystem unter Sog angeschlossen wird. Eine postoperative
Luftleckage wird von 42,1% der Kliniken nach dem 7. postoperativen Tag
behandelt. Die Luftleckage wird von der Mehrheit entweder durch eine Reduktion
des Sogs oder durch andere konservative Maßnahmen behandelt. Es zeigte sich kein
signifikanter Unterschied im Drainagemanagement zwischen High-Volume- und
Low-Volume-Zentren.
Schlussfolgerung Die Krankenhausverweildauer nach einer unkomplizierten
Lobektomie beträgt heute im Regelfall nur wenige Tage, wobei die untere
Grenzverweildauer bei 2 Tagen liegt. Dennoch definieren über 80% der deutschen
Zentren eine Luftleckage erst dann als prolongiert, wenn sie nach dem 5.
postoperativen Tag besteht; 65% behandeln sie auch erst dann. Die Studienlage
hierzu ist nicht richtungsweisend. Weitere prospektive klinische Studien sind
nötig, um die Behandlung der häufigsten Komplikation nach Lungenresektionen zu
verbessern.
The Independent Double-Row (IDR) Bony Bankart Repair Technique
Authors: Moroder Philipp , Paksoy Alp , Siegert Paul , Thiele Kathi , Lacheta Lucca , Akgün Doruk 
Published: February 2022

AbstractA displaced anterior glenoid rim fracture, the so-called bony Bankart lesion, occurs after a traumatic shoulder dislocation resulting from a high energy trauma and is associated with
recurrent shoulder instability. Different surgical techniques have been described in the literature to address this pathology, including open reduction and fixation, as well as arthroscopic
transosseous, and single-row or double-row approaches with the use of suture anchors. However, there is currently no gold standard of treatment and the stability of fixation and the healing
of the bony fragment are still a concern. The purpose of this report was to introduce an arthroscopic independent double-row (IDR) bony Bankart repair technique for fixation of large glenoid
fractures.
Iridium-Catalyzed Formal [4+1] Annulation of Benzamides and Cyclopropanols to Afford Isoindolin-1-one Derivatives via C–H Activation
Authors: Guan Mei , Wu Yong , Xu Shuran , Luo Cankun , Yan Kaichuan , Li Jianglian , Lai Ruizhi , Hai Li 
Published: February 2022

AbstractAn iridium-catalyzed reaction protocol has been developed to achieve the oxidative C–H/N–H annulation of benzamides with cyclopropanols as C1 synthon. Structurally diverse isoindolin-1-ones were furnished via sequential C–H/C–C cleavage and C–C/C–N bond formation.
Maternal Hypertension Disorders and Neonatal Acute Kidney Injury: Results from the AWAKEN Study
Authors: DeFreitas Marissa J. , Griffin Russell , Sanderson Keia , Nada Arwa , Charlton Jennifer R. , Jetton Jennifer G. , Kent Alison L. , Guillet Ronnie , Askenazi David , Abitbol Carolyn L. ,   on behalf of the Neonatal Kidney Collaborative,   University of Alabama, Birmingham,   Cincinnati Children's Hospital,   Canberra Hospital,   (currently at the University of Rochester),   Children's Hospital of Colorado,   (currently Cincinnati Children's Hospital, Cincinnati, OH); Children's Hospital at Montefiore/Albert Einstein,   Children's National Medical Center,   Golisano Children's Hospital University of Rochester,   (currently Union Hospital, Terre Haute),   Maimonides Medical Center,   McGill University,   Medanta, Medicity The Cradle,   Metrohealth Medical Center,   Nationwide Children's Hospital,   Stonybrook University,   Texas Children's Hospital,   Tufts Medical Center,   University of British Columbia,   University of Iowa,   Patrick Brophy (currently University of Rochester); University of Kentucky,   University of Miami,   University of Michigan,   (currently Medical University of South Carolina),   University of New Mexico,   (currently Texas Children's Hospital),   (currently University of Utah); University of Virginia,   (currently University of Wisconsin),   University of Washington
Published: February 2022

Objective This study aimed to examine the association between maternal hypertension (HTN) exposure and neonatal acute kidney injury (AKI).
Study Design Retrospective cohort study of 2,162 neonates admitted to 24 neonatal intensive care units (NICUs). Neonates were classified into the following exposure groups: any maternal HTN, chronic maternal HTN, preeclampsia/eclampsia, both, or neither. Demographics, clinical characteristics, and AKI status were compared using Chi-square and analysis of variance. General estimating logistic regression was used to estimate adjusted odds ratios and included a stratified analysis for site of delivery.
Result Neonates exposed to any maternal HTN disorder had a tendency toward less overall and early AKI. When stratified by inborn versus outborn, exposure to both maternal HTN disorders was associated with a significantly reduced odds of early AKI only in the inborn neonates.
Conclusion Exposure to maternal HTN, especially preeclampsia/eclampsia superimposed on chronic HTN, was associated with less likelihood of early AKI in the inborn group.
Key Points
Evaluation of the Clinical Performance of NuSmile Pedodontics Zirconia Crowns in Pulp-Treated Primary Teeth—2 Years Follow-Up Study
Authors: Alamoudi Rana A. , Walia Tarun , Debaybo Dina 
Published: February 2022

AbstractObjectives There is a lack of information regarding the longevity of prefabricated crowns on primary teeth. Therefore, the objective of the present study was to evaluate the clinical success rate of NuSmile pediatric Zirconia crowns in both primary anterior and posterior teeth up to 2 years in terms of gingival health, levels of plaque, restoration failure, and marginal integrity.Materials and Methods This interventional study evaluated the clinical performance of NuSmile primary Zirconia crowns on 232 (172 primary incisors and 60 primary molars) pulp-treated primary teeth. Statistical analysis included independent t-test and Kaplan–Meier survival method for which the level of significance was set up at p < 0.05.Results Gingival and plaque index of the teeth restored with NuSmile Zirconia crowns (test tooth) compared with adjacent and antagonist teeth (control tooth) showed no statistically significant difference at all time intervals (p > 0.05). The Kaplan–Meier survival graph indicated that only 34% of NuSmile Zirconia incisor crowns and 86% of NuSmile Zirconia molar crowns have survived at the end of 24 months. Of the 172 NuSmile Zirconia incisor crowns placed, only 82 teeth survived at the end of 2 years and the majority of the crowns completely lost the Zirconia crown. The Kaplan–Meier graph also indicated that more than two-thirds of crowns, i.e., 90% incisor crowns and 76% of molar crowns, had good marginal integrity at the end of 24 months.Conclusions Zirconia pediatric crowns preserve and maintain gingival health and have long-term survival rates with good retention and marginal integrity, indirectly preventing secondary caries. Hence, Zirconia pediatric crowns are a well-suited restoration of choice for primary teeth rehabilitation.
Evaluating Prediction of Continuous Clinical Values: A Glucose Case Study
Authors: Hripcsak George , Albers David J. 
Published: February 2022

Abstract
Background It would be useful to be able to assess the utility of predictive models of continuous values before clinical trials are performed.
Objective The aim of the study is to compare metrics to assess the potential clinical utility of models that produce continuous value forecasts.
Methods We ran a set of data assimilation forecast algorithms on time series of glucose measurements from neurological intensive care unit patients. We evaluated the forecasts using four sets of metrics: glucose root mean square (RMS) error, a set of metrics on a transformed glucose value, the estimated effect on clinical care based on an insulin guideline, and a glucose measurement error grid (Parkes grid). We assessed correlation among the metrics and created a set of factor models.
Results The metrics generally correlated with each other, but those that estimated the effect on clinical care correlated with others the least and were generally associated with their own independent factors. The other metrics appeared to separate into those that emphasized errors in low glucose versus errors in high glucose. The Parkes grid was well correlated with the transformed glucose but not the estimation of clinical care.
Discussion Our results indicate that we need to be careful before we assume that commonly used metrics like RMS error in raw glucose or even metrics like the Parkes grid that are designed to measure importance of differences will correlate well with actual effect on clinical care processes. A combination of metrics appeared to explain the most variance between cases. As prediction algorithms move into practice, it will be important to measure actual effects.
Quality of Life and Its Association with Level of Functioning in Young Children with Cerebral Palsy
Authors: Sharawat Indar Kumar , Panda Prateek Kumar 
Published: February 2022

Abstract
Introduction Quality of life (QOL) in older children, adolescents, and adults with cerebral palsy (CP) is significantly impaired. Level of functioning is one of the probable determinants of impairment in QOL. However, such studies in young children with CP are scarce in the literature.
Methods Parents of all consecutive children aged between 1 and 4 years with a confirmed diagnosis of CP completed the Infant Toddler Quality of Life (ITQOL) questionnaire. Total and individual subdomain scores of ITQOL were examined for association with the level of functioning measured by Gross Motor Function Classification System—Expanded & Revised (GMFCS E&R), Mini-Manual Ability Classification System (Mini-MACS), Communication Function Classification System (CFCS), and Eating and Drinking Ability Classification System (EDACS), with/without adjustment to probable confounding variables.
Results One hundred three children with CP (74 boys, mean age: 2.6 ± 0.9 years, 49% lower and 39% middle socioeconomic status) were enrolled. All four scales (GMFCS, Mini-MACS, CFCS, and EDACS) describing levels of functioning had significant association with ITQOL total score (β= –0.19, –0.15, –0.11, –0.09, respectively), which persisted even after adjusting for confounding variables (p = 0.004, 0.01, 0.03, and 0.046, respectively). Among the confounding variables, uncontrolled seizures, significant vision impairment, lower socioeconomic status, type of CP, and institution of comprehensive rehabilitation measures for ≥6 months had a significant association with ITQOL score (p = 0.03, 0.04, 0.02, 0.02, and 0.01, respectively).
Conclusion Level of functioning as measured by GMFCS, Mini-MACS, EDACS, and CFCS is independent predictors of impairment in QOL in young children with CP.
X-ray diagnostics of ECR ion sources—Techniques, results, and challenges
Authors: Thuillier T. , Benitez J. , Biri S. , Rácz R. 
Published: February 2022

The high magnetic confinement provided by the minimum-B structure of electron cyclotron resonance ion sources (ECRIS) hosts a non-equilibrium plasma, composed of cold multi-charged ions and hot electrons whose energy can expand up to ≈1 MeV. With a very limited accessibility, the ECR plasma is difficult to study. The x-ray photons generated by the interaction of the warm and hot electron populations within the plasma, as well as the photons generated by electrons lost to the chamber wall, are a signal of great interest as it gives an insight to the properties of the ECR plasma. After an introduction presenting the mechanism generating the x rays in ECRIS, this Review presents the methodology to measure x rays both for volumetric measurements and plasma imaging. The main insights of those measurements are presented. Prospects of x-ray measurements to better understand the plasma dynamics are finally highlighted.
The effect of alkylation on the micro-solvation of ethers revealed by highly localized water librational motion
Authors: Mihrin D. , Voute A. , Jakobsen P. W. , Feilberg K. L. , Wugt Larsen R. 
Published: February 2022

The specific far-infrared spectral signatures associated with highly localized large-amplitude out-of-plane librational motion of water molecules have recently been demonstrated to provide sensitive spectroscopic probes for the micro-solvation of organic molecules [Mihrin et al., Phys. Chem. Chem. Phys. 21(4), 1717 (2019)]. The present work employs this direct far-infrared spectroscopic approach to investigate the non-covalent intermolecular forces involved in the micro-solvation of a selection of seven ether molecules with systematically varied alkyl substituents: dimethyl ether, diethyl ether, diisopropyl ether, ethyl methyl ether, t-butyl methyl ether, and t-butyl ethyl ether. The ranking of the observed out-of-plane water librational band signatures for this selected series of ether–water complexes embedded in inert neon matrices at 4 K reveals information about the interplay of directional intermolecular hydrogen bond motifs and non-directional and long-range dispersion interactions for the micro-solvated structures. These far-infrared observables differentiate minor subtle effects introduced by specific alkyl substituents and serve as rigorous experimental benchmarks for modern quantum chemical methodologies of various levels of scalability, which often fail to accurately predict the structural variations and corresponding vibrational signatures of the closely related systems. The accurate interaction energies of the series of ether–water complexes have been predicted by the domain based local pair natural orbital coupled cluster theory with single-, double-, and perturbative triple excitations, followed by a local energy decomposition analysis of the energy components. In some cases, the secondary dispersion forces are in direct competition with the primary intermolecular hydrogen bonds as witnessed by the specific out-of-plane librational signatures.
Trigonella foenum-graecum morphophysiological and phytochemical processes controlling iron uptake and translocation
Authors: Mnafgui Wiem , Rizzo Valeria , Muratore Giuseppe , Hajlaoui Hichem , Schinoff Bianca de Oliveira , Mnafgui Kais , Elleuch Amine 
Published: February 2022

Context Iron (Fe) is considered as a major cause of rural Tunisian soil contamination. Developing strategies for the cultivation of accumulator plants with permissible iron (Fe) concentrations is an urgent challenge. Aims In this study, the effects of FeSO4 concentration (0, 50, 500 and 1000 mg L−1) on fenugreek morpho-biochemical parameters were investigated. Methods The use of fenugreek as a phytoremediation strategy to control not only the uptake of Fe but also its safe consumption after treatments was evaluated. Key results Results showed that elevated Fe concentrations did not affect the germination rate, but, rather, decreased the radicle length and amylase activity. The elemental analysis showed that Fe uptake was higher in shoots than in roots, but lower in harvested seeds. The translocation factor was higher than 1, suggesting a safe use of fenugreek as an accumulator. Moreover, the increase in Fe concentrations reduced the chlorophyll content and enhanced the production of lipid peroxidation, hydrogen peroxide and superoxide dismutase more frequently on fenugreek shoots than on their roots. In turn, the maximum concentrations of flavonoids and phenols were recorded under the Fe concentration of 50 mg L−1. High-performance liquid chromatography analysis showed that the gallic and syringic acids were the major phenols produced under Fe stress in shoots and that 50 mg L−1 of added Fe concentration induced their elevation. However, the quercetin was detected only in roots and was reduced under the increasing Fe concentrations. Conclusions These results showed that fenugreek is an accumulator plant with admissible concentrations of Fe accumulation, which deploys multiple mechanisms to adapt to Fe stress.