bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tumor Molecular Profiling in Hispanics: Moving Towards Precision Oncology and Health Equity
Authors: Mendez Rodríguez Sariemma , Rodríguez-Hernández Aida M. , Torres-Torres Gabriela , Centeno-Girona Hilmaris , Cruz-Correa Marcia 
Published: June 2022

Abstract
Background
Tumor molecular profiling techniques, such as next-generation sequencing (NGS) to identify somatic genetic alterations, allow physicians to have a better understanding of the affected carcinogenic pathways and guide targeted therapy. The objective of our study was to characterize common somatic alterations and carcinogenic pathways among Puerto Rican Hispanics with solid tumors.

Methods
We conducted a single-institution, retrospective study to characterize molecular tumor profiles using a 592-gene NGS platform. Actionable mutations with current or developing therapies targeting affected genes/pathways were highlighted.

Results
Tumors from 50 Hispanic patients were evaluated using CARIS Life Science© NGS testing. The median age of our study population was 55 (range 21–84); 54% (n = 27) were males. The primary tumor sites were colorectal (n = 24), gastric (n = 5), breast (n = 4), and lung (n = 3). The most common genetic mutations identified were in TP53 (44%), APC (38%), and KRAS (32%); followed by alterations in EGFR (4%), HER2 (6%), and homologous recombinant deficiency genes (BRCA2, 6%). Genetic alterations were found in multiple signaling pathways particularly in the cell cycle control pathway, MAPK and Wnt/β-Catenin signaling pathways. Targetable biomarkers were identified in 27/50 (54.0%) of tumors.

Discussion
Molecular profiling techniques, such as next-generation sequencing, have substantially expanded access to alterations in the cancer genome. Our findings demonstrated important actionable mutations in most of the tumors evaluated and support the integration of somatic mutation profiling in the evaluation of Hispanic cancer patients with advanced cancer to help guide therapeutic options.
Sorption kinetics of 1,3,5-trinitrobenzene to biochars produced at various temperatures
Authors: Zhu Hongxia , Liu Xianyu , Jiang Yuan , Lin Daohui , Yang Kun 
Published: June 2022

AbstractSorption kinetics of organic compounds on biochars is important for understanding the retardation of mobility and bioavailability of organic compounds. Herein, sorption kinetics of 1,3,5-trinitrobenzene on biochars prepared from 200 to 700 °C was investigated to explore the sorption process. Loose partition matrix and condensed partition matrix were formed at relatively low and moderate temperatures, respectively. However, biochars produced at relatively high temperatures formed rich pore structures. Therefore, sorption equilibrium time of 1,3,5-trinitrobenzene increased with increasing preparation temperature from 200 to 350 °C due to the slower diffusion rate in the more condensed matrix, and then decreased when preparation temperature was higher than 400 °C because of the faster adsorption rate in the greater number of pores. Linear positive relationship between matrix diffusion rates of 1,3,5-trinitrobenzene on biochars prepared at 200, 250, 300, 350 °C and H/C ratios of biochars was observed, suggesting that the inhibition of partition process was caused by the condensed matrix in biochars. Linear positive relationships between adsorption rates (i.e., fast outer diffusion rate and slow pore diffusion rate) of 1,3,5-trinitrobenzene on biochars prepared at 400, 450, 550, 700 °C and graphite defects of biochars were observed, because the increase of graphite defects of biochars could promote the adsorption by increasing the quantity of fast diffusion channels and sorption sites. This study reveals the underlying mechanisms of sorption kinetics for organic compounds with relatively large size on biochars, which has potential guidance for the application of biochars and prediction of the environmental risks of organic compounds.
Graphical Abstract
Lung Cancer Patients’ Characteristics and Comorbidities Using the Korean National Hospital Discharge In-depth Injury Survey Data
Authors: Lee Kyunghee , Kang Sunghong , Hwang Jieun 
Published: June 2022

Abstract
Background
The aim of this study was to assess the incidence of lung cancer and comorbidities in Korea and analyze the lung cancer patient’s characteristics and their comorbidities over the past 12 years. This study also aimed to investigate factors related to death as treatment outcome in discharged lung cancer patients.

Methods
This study analyzed the data obtained from the Korean National Hospital Discharge In-depth Injury Survey from 2006 to 2017. The quantity of discharged lung cancer patients was assessed by year. Comorbidities were limited to those included in the Elixhauser Comorbidity Index (ECI). A Chi-square test was performed to determine statistically significant differences in the distributions of the ECI and ECI scores according to the presence or absence of metastatic cancer. Logistic regression analysis was used to analyze factors related to death as treatment outcome.

Results
From 2006 to 2017, the number of discharged male and female patients with lung cancer increased from 31,720 to 42,016 and 10,897 to 18,197, respectively. The increase in the number of lung cancer patients was greater in women than in men (67.0% vs. 32.5%, respectively). The most common associated comorbidities were hypertension, diabetes, and chronic pulmonary disease. The factors related to death as treatment outcome were found to include sex, admission route, number of hospital beds, length of stay, presence or absence of metastatic cancer, and ECI score.

Conclusion
The number of lung cancer patients in Korea has increased, and a high proportion of these patients have chronic diseases, which negatively would impact the treatment and outcome of lung cancer patients as well as their quality of life. Thus, the management of chronic diseases needs to be prioritized in patients with lung cancer.
Time of Historicism, Print Revival, and Parsi Patronage of Architecture, 1887–1936
Authors: Grigor Talinn 
Published: June 2022

AbstractFocusing on the decades between 1887 and 1936, this article examines the relationship between the Parsi-Iranian network of the printed text—often sustained by abundant visual evidence—and the built environment that then returned onto the published pages of printed books and periodicals. It examines several seminal Parsi and Iranian texts, all of which were published in the Bombay-based Parsi press, containing images of outstanding architectural edifices erected in Iran with Parsi financing to map the broader political discourse on modern reform through the strategy of an artistic revival. The piece foregrounds the codependence of Parsi patronage of print and built architecture. Architecture itself is treated as a text that aimed to ground the instability of language and identity in solid foundations. This codependent relation helped support a modernist discourse on Iranian nationalist rebirth.
Presidential Electoral Cycles and Corruption Charges
Authors: Amick Joe , Bukovansky Mlada , Liu Amy H. 
Published: June 2022

AbstractAnti-corruption efforts are inherently political. Corruption charges can be levied against political opponents as an instrument of repression; they can also be used against troublesome allies in the same party coalition to further consolidate power. In this paper, we focus on Indonesia and ask: Do major corruption charges follow a presidential electoral cycle—and if so, how? We contend charges against prominent members of the government coalition are more likely to happen before an election, allowing the government to replace intra-party rivals with loyal allies. Conversely, charges against prominent opposition members are more likely to happen after an election when fears of retaliation are low, opportunities for credit-claiming are high, and there is an incentive to remove veto players who may inhibit implementing the government's agenda. To test this argument, we use an original, newly assembled dataset of all major corruption charges—i.e., those involving high-profile politicians and garnering international attention—in Indonesia from 1998–2015 as reported in the Associated Press. We find a significant and robust relationship between the electoral calendar and major corruption charges. This relationship is robust across presidential administrations. These results yield insights into how anti-corruption efforts can become a political tool and counsel caution about the effectiveness of “good governance,” especially in new democracies. Finally, we discuss how contextual political factors external to Indonesia's anti-corruption commission, reinforce this empirical pattern.
“A Feminism For the Many”: Response to the Comments
Authors: Cobble Dorothy Sue 
Published: June 2022

AbstractFor the Many: American Feminists and the Global Fight for Democratic Equalityrecasts American feminism as a global story and reclaims the fight for economic justice and social democracy as a majority tradition of women's politics. This rejoinder by the author ofFor the Manyis the concluding essay in a review dossier on the book. Cobble discusses the book's origins and its contributions to global history, women's history, and political history. She engages with comments and queries from dossier reviewers, a diverse group of historians of Latin America, South Asia, Africa, and Europe. Topics include, among others, the unfinished struggle to revalue care and social reproduction, the influence of India on US feminism, Black internationalism and full-rights feminism, varieties of socialism, rethinking Cold War frameworks, and feminist perspectives on eugenics, race, and sexuality.
Participation without Contestation: NGOs’ Autonomy and Advocacy in China
Authors: Su Zheng , Ma Shiqi , Zhang Changdong 
Published: June 2022

AbstractHow do non-governmental organizations (NGOs) advocate public policies? What impacts their advocacy strategies? Although scholars have addressed these questions in a democratic context, less is known about NGO advocacy under powerful authoritarian regimes. Using China as a case study, we develop an institutional explanation of NGOs’ policy advocacy patterns and explore the impacts of NGO autonomy. Using a unique dataset of registered NGOs in three Chinese provinces, we find that NGOs with more autonomy tend to conduct direct negotiations with the government more actively (more political advocacy). However, these more autonomous NGOs are likely to be more hesitant to mobilize society from the bottom up (less social advocacy). These findings enrich our knowledge of social actors’ roles in the policymaking process in China.
Barriers and enablers to menu planning guideline implementation in Australian childcare centres and the role of government support services
Authors: Elford Audrey , Spence Alison , Wakem Amy , Campbell Karen J , Love Penelope 
Published: June 2022

AbstractObjective:To explore government support service access, perceived barriers/enablers to menu planning and menu compliance in long day care (LDC) centres in Victoria, Australia, where the Victorian Government-funded Healthy Eating Advisory Service (HEAS) is available to provide free LDC menu planning support.Design:This is a cross-sectional study design. Data were collected from online surveys with the option of uploading 2 weeks of menus and recipes. Menu compliance was scored for quantity, quality and variety. Barriers/enablers to menu planning guideline implementation were determined using the Theoretical Domains Framework (TDF). Independent t tests, one-way ANOVA and chi-square tests assessed relationships between characteristics, barriers/enablers and menu scores.Setting:Eighty-nine LDC centres that prepare food onsite.Participants:LDC staff responsible for menu planning (n 89) and menus from eighteen centres.Results:Fifty-five per cent of centres had accessed HEAS. Of eighteen provided menus, only one menu was compliant with menu planning guidelines. HEAS access was associated with higher average scores in four of seven TDF domains, namely knowledge/awareness, skills/role, reinforcement/influence and optimism/intent. There were no correlations between menu score and barriers/enablers; however, menu quality scores were higher for those accessing HEAS.Conclusions:Childcare-specific government support services may be an important public health nutrition strategy and may improve menu planning guideline implementation as well as menu quality; however, this does not necessarily translate into menu compliance. Research should confirm these findings in larger studies to ascertain uptake of these services. Public health efforts should focus on exploring barriers and enablers to uptake of government support services to increase reach and acceptability.
The ferns in a new Middle Jurassic locality from the Otlaltepec Formation, Puebla, Mexico
Authors: MORALES-TOLEDO Jeronimo , MENDOZA-RUIZ Aniceto C. , CEVALLOS-FERRIZ Sergio R. S. 
Published: June 2022

ABSTRACT
Mesozoic ferns from Mexico have been the subject of serious academic endeavours since the beginning of the 20th Century, to understand these plants at the time of their peak diversity. Most findings have been made in a set of Middle Jurassic Basins of the Mixtec Terrain in the Oaxaca State. However, fossil ferns are scarce in other assemblages, so further identification of this group has been infrequent. Here we describe six new and recently collected fossil plants from the Middle Jurassic Otlaltepec Formation, Puebla. Based on their fertile and vegetative fronds, we propose the new genus Paralophosoria Morales-Toledo, Mendoza-Ruiz & Cevallos-Ferriz, gen. nov. in the Dicksoniaceae, represented by Paralophosoria jurassica, Morales-Toledo, Mendoza-Ruiz & Cevallos-Ferriz, sp. nov., and identify the following genera: cf. Aspidistes, Sphenopteris, Spiropteris. A fern with uncertain affinities was also described. This work contributes to the understanding of fern diversity in low latitudes during the Middle Jurassic in Mexico.
Evidence for moiré intralayer excitons in twisted WSe2/WSe2 homobilayer superlattices
Authors: Wu Biao , Zheng Haihong , Li Shaofei , Ding Junnan , He Jun , Zeng Yujia , Chen Keqiu , Liu Zongwen , Chen Shula , Pan Anlian , Liu Yanping 
Published: June 2022

AbstractRecent advances in twisted van der Waals heterostructure superlattices have emerged as a powerful and attractive platform for exploring novel condensed matter physics due to the interplay between the moiré potential and Coulomb interactions. The moiré superlattices act as a periodic confinement potential in space to capture interlayer excitons (IXs), resulting in moiré exciton arrays, which provide opportunities for quantum emitters and many-body physics. The observation of moiré IXs in twisted transition-metal dichalcogenide (TMD) heterostructures has recently been widely reported. However, the capture and study of the moiré intralayer excitons based on TMD twisted homobilayer (T-HB) remain elusive. Here, we report the observation of moiré intralayer excitons in a WSe2/WSe2 T-HB with a small twist angle by measuring PL spectrum. The multiple split peaks with an energy range of 1.55–1.73 eV are different from that of the monolayer WSe2 exciton peaks. The split peaks were caused by the trapping of intralayer excitons via the moiré potential. The confinement effect of the moiré potential on the moiré intralayer excitons was further demonstrated by the changing of temperature, laser power, and valley polarization. Our findings provide a new avenue for exploring new correlated quantum phenomena and their applications.
Fecal microbiota transplantation from patients with rheumatoid arthritis causes depression-like behaviors in mice through abnormal T cells activation
Authors: Pu Yaoyu , Zhang Qiuping , Tang Zhigang , Lu Chenyang , Wu Liang , Zhong Yutong , Chen Yuehong , Hashimoto Kenji , Luo Yubin , Liu Yi 
Published: June 2022

AbstractDepression is common in patients with rheumatoid arthritis (RA); however, the precise mechanisms underlying a link between depression and RA remain unclear. Accumulating evidence suggests the role of gut–microbiota–brain axis in depression. In this study, we investigated whether collagen-induced arthritis (CIA) mice produce depression-like behaviors and abnormal composition of gut microbiota. Furthermore, we investigated whether fecal microbiota transplantation (FMT) from RA patients causes depression-like phenotypes in antibiotic cocktail (ABX)-treated mice. CIA mice displayed depression-like behaviors, increased blood levels of pro-inflammatory cytokine interleukin-6 (IL-6), decreased expression of synaptic proteins in the prefrontal cortex (PFC), and abnormal composition of gut microbiota. Furthermore, FMT from RA patients caused depression-like phenotypes, alterations of gut microbiota composition, increased levels of IL-6 and tumor necrosis factor-α (TNF-α), and downregulation of synaptic proteins in the PFC compared to FMT from healthy controls. There were correlations between relative abundance of microbiota and plasma cytokines, expression of synaptic proteins in the PFC or depression-like behaviors. Interestingly, FMT from RA patients induced T cells differentiation in Peyer’s patches and spleen. Reduced percentage of Treg cells with an increase of Th1/Th2 index was observed in the mice after FMT from RA patients. These findings suggest that CIA mice exhibit depression-like behaviors, systemic inflammation, and abnormal composition of gut microbiota, and that FMT from RA patients produces depression-like behaviors in ABX-treated mice via T cells differentiation. Therefore, abnormalities in gut microbiota in RA patients may contribute to depression via gut–microbiota–brain axis.
Whole genome sequencing reveals hidden transmission of carbapenemase-producing Enterobacterales
Authors: Marimuthu Kalisvar , Venkatachalam Indumathi , Koh Vanessa , Harbarth Stephan , Perencevich Eli , Cherng Benjamin Pei Zhi , Fong Raymond Kok Choon , Pada Surinder Kaur , Ooi Say Tat , Smitasin Nares , Thoon Koh Cheng , Tambyah Paul Anantharajah , Hsu Li Yang , Koh Tse Hsien , De Partha Pratim , Tan Thean Yen , Chan Douglas , Deepak Rama Narayana , Tee Nancy Wen Sim , Kwa Andrea , Cai Yiying , Teo Yik-Ying , Thevasagayam Natascha May , Prakki Sai Rama Sridatta , Xu Weizhen , Khong Wei Xin , Henderson David , Stoesser Nicole , Eyre David W. , Crook Derrick , Ang Michelle , Lin Raymond Tzer Pin , Chow Angela , Cook Alex R. , Teo Jeanette , Ng Oon Tek ,   Carbapenemase-Producing Enterobacteriaceae in Singapore (CaPES) Study Group, Marimuthu Kalisvar , Venkatachalam Indumathi , Cherng Benjamin Pei Zhi , Fong Raymond Kok Choon , Pada Surinder Kaur , Ooi Say Tat , Smitasin Nares , Thoon Koh Cheng , Hsu Li Yang , Koh Tse Hsien , De Partha Pratim , Tan Thean Yen , Chan Douglas , Deepak Rama Narayana , Tee Nancy Wen Sim , Ang Michelle , Lin Raymond Tzer Pin , Teo Jeanette , Ng Oon Tek 
Published: June 2022

AbstractCarbapenemase-producing Enterobacterales (CPE) infection control practices are based on the paradigm that detected carriers in the hospital transmit to other patients who stay in the same ward. The role of plasmid-mediated transmission at population level remains largely unknown. In this retrospective cohort study over 4.7 years involving all multi-disciplinary public hospitals in Singapore, we analysed 779 patients who acquired CPE (1215 CPE isolates) detected by clinical or surveillance cultures. 42.0% met putative clonal transmission criteria, 44.8% met putative plasmid-mediated transmission criteria and 13.2% were unlinked. Only putative clonal transmissions associated with direct ward contact decreased in the second half of the study. Both putative clonal and plasmid-mediated transmission associated with indirect (no temporal overlap in patients’ admission period) ward and hospital contact did not decrease during the study period. Indirect ward and hospital contact were identified as independent risk factors associated with clonal transmission. In conclusion, undetected CPE reservoirs continue to evade hospital infection prevention measures. New measures are needed to address plasmid-mediated transmission, which accounted for 50% of CPE dissemination.
Effects of sex, age, choice of surgical orthodontic treatment, and skeletal pattern on the psychological assessments of orthodontic patients
Authors: Hino Sayaka , Maeda-Iino Aya , Yagi Takakazu , Nakagawa Shoko , Miyawaki Shouichi 
Published: June 2022

AbstractWe aimed to examine the effects of sex, age, choice of surgical orthodontic treatment, and skeletal pattern on psychological assessment scores of orthodontic patients before edgewise treatment. They completed the State-Trait Anxiety Inventory (STAI), Beck Depression Inventory (BDI)-II, and the psychological domain of the World Health Organization Quality of Life 26 (Psych-QOL) for assessment of anxiety, depression, and body image, respectively. No significant effects on psychological assessment scores due to sex or age differences were found. Surgical orthodontic treatment patients and patients with skeletal Class III had significantly higher STAI-Trait and/or BDI-II scores and lower Psych-QOL score. Based on the linear mixed-effects model, the choice of surgical orthodontic treatment had a significant effect on the STAI-Trait, BDI-II, and Psych-QOL scores. No significant interaction effect was found between the choice of surgical orthodontic treatment and the skeletal pattern by ANB angle. Patients with skeletal Class I or III who chose surgical orthodontic treatment had higher STAI-Trait and/or BDI-II scores and/or lower body image score, respectively. These results suggest that patients who chose surgical orthodontic treatment, particularly those with skeletal Class I and III, may be more prone to experience anxiety and depression and have body image dissatisfaction.
The impact of ultra-high-density mapping on long-term outcome after catheter ablation of ventricular tachycardia
Authors: Schleberger Ruben , Schwarzl Jana M. , Moser Julia , Nies Moritz , Höller Alexandra , Münkler Paula , Dinshaw Leon , Jungen Christiane , Lemoine Marc D. , Maury Philippe , Sacher Frederic , Martin Claire A. , Wong Tom , Estner Heidi L. , Jaïs Pierre , Willems Stephan , Eickholt Christian , Meyer Christian 
Published: June 2022

AbstractUltra-high-density (UHD) mapping can improve scar area detection and fast activation mapping in patients undergoing catheter ablation of ventricular tachycardia (VT). The aim of the present study was to compare the outcome after VT ablation guided by UHD and conventional point-by-point 3D-mapping. The acute and long-term ablation outcome of 61 consecutive patients with UHD mapping (64-electrode mini-basket catheter) was compared to 61 consecutive patients with conventional point-by-point 3D-mapping using a 3.5 mm tip catheter. Patients, whose ablation was guided by UHD mapping had an improved 24-months outcome in comparison to patients with conventional mapping (cumulative incidence estimate of the combination of recurrence or disease-related death of 52.4% (95% confidence interval (CI) [36.9–65.7]; recurrence: n = 25; disease-related death: n = 4) versus 69.6% (95% CI [55.9–79.8]); recurrence: n = 31; disease-related death n = 11). In a cause-specific Cox proportional hazards model, UHD mapping (hazard ratio (HR) 0.623; 95% CI [0.390–0.995]; P = 0.048) and left ventricular ejection fraction > 30% (HR 0.485; 95% CI [0.290–0.813]; P = 0.006) were independently associated with lower rates of recurrence or disease-related death. Other procedural parameters were similar in both groups. In conclusion, UHD mapping during VT ablation was associated with fewer VT recurrences or disease-related deaths during long-term follow-up in comparison to conventional point-by-point mapping. Complication rates and other procedural parameters were similar in both groups.