bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ultrasound super-resolution imaging for the differential diagnosis of thyroid nodules: A pilot study
Authors: Zhang Ge , Yu Jing , Lei Yu-Meng , Hu Jun-Rui , Hu Hai-Man , Harput Sevan , Guo Zhen-Zhong , Cui Xin-Wu , Ye Hua-Rong 
Published: October 2022

ObjectiveUltrasound imaging provides a fast and safe examination of thyroid nodules. Recently, the introduction of super-resolution imaging technique shows the capability of breaking the Ultrasound diffraction limit in imaging the micro-vessels. The aim of this study was to evaluate its feasibility and value for the differentiation of thyroid nodules.MethodsIn this study, B-mode, contrast-enhanced ultrasound, and color Doppler flow imaging examinations were performed on thyroid nodules in 24 patients. Super-resolution imaging was performed to visualize the microvasculature with finer details. Microvascular flow rate (MFR) and micro-vessel density (MVD) within thyroid nodules were computed. The MFR and MVD were used to differentiate the benign and malignant thyroid nodules with pathological results as a gold standard.ResultsSuper-resolution imaging (SRI) technique can be successfully applied on human thyroid nodules to visualize the microvasculature with finer details and obtain the useful clinical information MVD and MFR to help differential diagnosis. The results suggested that the mean value of the MFR within benign thyroid nodule was 16.76 ± 6.82 mm/s whereas that within malignant thyroid was 9.86 ± 4.54 mm/s. The mean value of the MVD within benign thyroid was 0.78 while the value for malignant thyroid region was 0.59. MFR and MVD within the benign thyroid nodules were significantly higher than those within the malignant thyroid nodules respectively (p &lt; 0.01).ConclusionsThis study demonstrates the feasibility of ultrasound super-resolution imaging to show micro-vessels of human thyroid nodules via a clinical ultrasound platform. The important imaging markers, such as MVD and MFR, can be derived from SRI to provide more useful clinical information. It has the potential to be a new tool for aiding differential diagnosis of thyroid nodules.
Surgical options of the breast and clinical outcomes of breast cancer patients after neoadjuvant chemotherapy: A single-center retrospective study
Authors: Sang Yuting , Zhou Xujie , Chi Weiru , Chen Jiajian , Yang Benlong , Hao Shuang , Huang Xiaoyan , Liu Guangyu , Shao Zhimin , Wu Jiong 
Published: October 2022

BackgroundNeoadjuvant chemotherapy (NAC) has evolved significantly and has been widely accepted for downstaging disease in early-stage and locally advanced breast cancer patients. Since the optimal surgical intervention for patients receiving NAC remains controversial, we aim to investigate the survival outcome of patients treated with different surgical management.MethodsA retrospective, nested case-control study was conducted in patients with invasive breast cancer that underwent NAC at Fudan University Shanghai Cancer Center from January 2010 to June 2019. Based on surgical intervention, patients were divided into mastectomy and breast conservation groups. Patients were matched on age at diagnosis, menopausal status, the year of the surgery, post neoadjuvant therapy pathological tumor (ypT) stage, post neoadjuvant therapy pathological node (ypN) stage, molecular subtypes, and axillary surgery by propensity score matching.ResultsA total of 2080 patients were enrolled in this study. Among them, 1819 (87.5%) patients were categorized as mastectomy group, and 261 (12.5%) patients were classed as breast conservation group. Over 9-years of research, the proportion of breast conservation steadily increased in patients after NAC. Data showed that younger (P&lt;0.001) and pre-menopausal (P&lt;0.001) patients with normal BMI (P=0.022) were more likely to receive breast conservation. Patients at advanced ypT stage (P&lt;0.001), ypN stage (P&lt;0.001), and clinical TNM stage (P&lt;0.001) were more often to undergo mastectomy, while breast conservation rate was significantly higher in patients with triple-negative tumors (P=0.023). Compared with the mastectomy group, significant benefits in overall survival were observed in patients who received breast conservation (Hazard ratio 0.41, [95% confidence interval: 0.18-0.97]; p=0.049) in the matched cohort. There was no statistical difference between groups related to disease-free survival and locoregional recurrence.ConclusionsTumor biology can significantly impact the surgical decision in patients administrated with NAC. Breast conservation was a safe alternative for mastectomy in the NAC setting without compromising survival outcomes and locoregional control.
L1CAM expression in either metastatic brain lesion or peripheral blood is correlated with peripheral platelet count in patients with brain metastases from lung cancer
Authors: Wang Jia-Wei , Wang Hong-Liang , Liu Qi , Hu Ke , Yuan Qing , Huang Sheng-Kai , Wan Jing-Hai 
Published: October 2022

BackgroundSystemic immune-inflammation states across the heterogeneous population of brain metastases from lung cancer are very important, especially in the context of complex brain-immune bidirectional communication. Previous studies from our team and others have shown that the L1 cell adhesion molecule (L1CAM) is deeply involved in the aggressive phenotype, immunosuppressive tumor microenvironment (TME), and metastasis during multiple malignancies, which may lead to an unfavorable outcome. However, little is known about the relationship between the L1CAM expression and the systemic immune-inflammation macroenvironment beyond the TME in brain metastases from lung cancer.MethodsTwo cohorts of patients with brain metastases from lung cancer admitted to the National Cancer Center, Cancer Hospital of Chinese Academy of Medical Sciences, were studied in the present research. The L1CAM expression in cranial metastatic lesions by immunohistochemistry was explored in patients treated with neurosurgical resection, whereas the L1CAM expression in peripheral blood by ELISA was tested in patients treated with non-surgical antitumor management. Furthermore, based on peripheral blood cell counts in the CBC test, six systemic immune-inflammation biomarkers [neutrophil count, lymphocyte count, platelet count, systemic immune-inflammation index (SII), neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio] were calculated. Then, the relationship between the L1CAM expression and these systemic immune-inflammation biomarkers was analyzed. In addition, these systemic immune-inflammation biomarkers were also used to compare the systemic immune-inflammation states in two cohorts of patients with brain metastases from lung cancer.ResultsPositive L1CAM expressions in the metastatic brain lesions were accompanied with significantly increased peripheral platelet counts in patients treated with neurosurgical tumor resection (P &lt; 0.05). Similarly, in patients treated with non-surgical antitumor management, L1CAM expressions in the peripheral blood were positively correlated with peripheral platelet counts (P &lt; 0.05). In addition, patients prepared for neurosurgical tumor resection were presented with poorer systemic immune-inflammation states in comparison with the one with non-surgical antitumor management, which was characterized by a significant increase in peripheral neutrophil counts (P &lt; 0.01), SII (P &lt; 0.05), and NLR (P &lt; 0.05) levels.ConclusionThe L1CAM expression in either the metastatic brain lesion or peripheral blood is positively correlated with the peripheral platelet count in patients with brain metastases from lung cancer. In addition, brain metastases that are prepared for neurosurgical tumor resection show poor systemic immune-inflammation states.
Modern Serological Diagnosis of Toxoplasmosis: Literature Review
Authors: Мицура В.М. 
Published: October 2022

Представлен обзор литературных источников на английском и русском языках, посвященный оценке значения серологических методов лабораторной диагностики токсоплазмоза на современном этапе. Для диагностики токсоплазмоза необходимы лабораторные исследования, поскольку клинические проявления очень разнообразны. Токсоплазмоз у иммунокомпетентных лиц можно диагностировать с помощью серологических тестов (например, иммуноферментного анализа). Выявление специфических антител к T. gondii классов IgM и IgG позволяет определить факт инфицирования, однако не всегда возможно с их помощью диагностировать острую инфекцию. Для повышения эффективности диагностики острой или недавней инфекции используют определение авидности антител IgG, исследование на антитела класса IgA. Разработаны новые методики, основанные на использовании рекомбинантных антигенов токсоплазмы, иммунохроматографические тесты, исследование слюны и др. Следует стремиться к максимально ранней диагностике острого инфицирования токсоплазмой беременных и использовать для этого все имеющиеся возможности серологической диагностики.
A review of literature sources in English and Russian is presented, devoted to the assessment of the significance of serological methods for the laboratory diagnosis of toxoplasmosis at the present time. Laboratory tests are necessary to diagnose toxoplasmosis, since the clinical manifestations are very diverse. Toxoplasmosis in immunocompetent individuals can be diagnosed using serological tests (eg, enzyme linked immunosorbent assay). Detection of specific antibodies against T. gondii of the IgM and IgG classes makes it possible to determine the fact of infection, but it is not always possible to diagnose an acute infection by them. To improve the efficiency of diagnosing an acute or recent infection, the detection of the avidity of IgG antibodies, the study of antibodies of the IgA class, are used. New methods have been developed based on the use of recombinant toxoplasma antigens, immunochromatographic tests, saliva testing, and others. It is necessary to strive for the earliest possible diagnosis of acute infection with Toxoplasma in pregnant women and use all available possibilities for serological diagnosis for this.
Studi Numerik Pengaruh Sudut Kemiringan Sudu Terhadap Performa Turbin Angin Vertikal Tipe Savonius
Authors: Masykur Masykur , Kurniadi Andre , Saputra Maidi , Murhaban Murhaban 
Published: October 2022

AbstractWind energy is a renewable energy source that can be felt in everyday life. To convert wind energy into electrical energy, a tool is needed that is a wind turbine. Horizontal Axis Wind Turbine is more widely used and developed today than the vertical type wind turbine. However, the vertical turbine has several advantages compared to the horizontal wind turbine, which is that it can move without depending on the direction of the wind. This study aims to determine the effect of tilt angel of savonius turbine with blades angle 30°, 60° and 90° the turbine power coefficient and determine the optimal turbine blade results in designing a Vertical wind turbine by simulation using Computational Fluid Dynamics (CFD). The variations used are tilt angel turbine blades is 30°, 60°, 90°. The results showed that the value of Cp (Power Coefficient) of wind turbines with the addition of the blade angel 30°, 60° and 90° had a different increase. The variation the addition of turbine blade tilt angle with 90° tilt angle can increase the efficiency of the turbine blade when compared 30°, 60° blade inclination this is evidenced by wind turbine speed contour analysis, wind vortex contour analysis and turbulence intensity contour analysis shows that the turbine blade simulation results with a slope of 90° has an efficient turbine blade that is very good and effective and get optimal results.Keywords: Wind turbine, VAWT, CFD, Efficiency, Contour, Optimal, TSR, power
ANALISA KERUSAKAN DAN PERBAIKAN TRACK ROLLER PADA EXCAVATOR HITACHI ZAXIS 200 E PT.BEURATA SUBUR PERSADA
Authors: Irfan Irfan , Ali Sulaiman 
Published: October 2022

PT. Beurata Subur Peusada ialah perusahaan yang bergerak di bidang pengolahan minyak kelapa sawit (PMKS).Untuk mendapatkan produksi minyak kelapa sawit yang berkualitas dan bermutu maka harus di dukung dengan mesin produksi yang baik. terutama pada alat berat yang banyak mengalami kendala, karena di pengaruhi usia mesin yang sudah berumul lebih dari 10 tahun. Roller berperan buat menopang berat dari excavator serta track pad pada undercarriage. Analisa ini bertujuan buat mengenali tipe kehancuran, aspek pemicu kehancuran, mengenali langkah perawatan serta revisi pada roller Excavator HITACHI ZAXIS 200E. Prosedur pengecekan dicoba dengan melaksanakan performance test yang terdiri dari thermogun test pada tiap bagian komponen undercarriage. Pengecekan pula dicoba secara visual pada undercarriage serta roller. Berikutnya dicoba analisa tipe kehancuran pada roller serta sudah dikenal aspek pemicu rusakannya roller pada excavator. Hasil analisa kehancuran pada roller, ada 2 tipe kehancuran pada roller ialah; yang awal: terjalin kehancuran pada bagian luar komponen roller yang diakibatkan oleh tanah yang melekat serta membeku menyebabkan keausan permukaan pada roller, yang kedua: terjalin kehancuran pada bagian dalam roller diakibatkan oleh floating seal yang di pasang terjalin kebocoran oli menyebabkan keausan bushing serta shaft akibat gesekan. Permasalahan serta kehancuran bisa di mengurangi dengan mempraktikkan perawatan yang pas pada roller semacam mensterilkan saat sebelum merakitnya. Perihal yang berarti merupakan senantiasa bilas serta mengubah pelumas dari roller serta pula zona kerja pula wajib bersih.
KADAR EMISI GAS BUANG PADA SI ENGINE 4 STROKE-LPG FUEL DENGAN VARIASI BUKAAN KATUP GAS
Authors: Romandoni Nanang , Wahyudi Noorsakti , Faizin Kholis Nur , Fadillah Firdho Putra 
Published: October 2022

Abstract The use of LPG fuel in spark ignition engines continues to be developed, including the use of converter kits as a conversion tool from gasoline to LPG. However, the use of converter kits is not optimal because the mixture of air and gas has not been mixed heterogeneously in the combustion chamber. Therefore, it is necessary to redesign the converter kits that speed up the mixing process between air and gas. This study aims to evaluate the use of LPG fuel in spark ignition engines with converter kits on variations in throttle valve openings on exhaust gas emissions and exhaust gas temperatures. The research method used is an experiment with variations in the throttle valve opening on the engine are 25%, 50%, 75%, and 100%. Data that will be compared on the use of gasoline and LPG fuels include carbon monoxide (CO), hydrocarbon (HC), and mean gas temperature. The results showed that the use of fuel between gasoline and LPG on exhaust gas emission levels in spark ignition engines with variations in throttle valve openings was able to reduce CO emissions by 92% on average, HC by 72%, and increase the mean average temperature by 17%. This shows that the use of converter kits at each valve opening is able to reduce levels of CO and HC exhaust emissions compared to gasoline. However, it is inversely proportional to the mean gas temperature, at each variation of the gas valve opening there is a significant increase in temperature. This is because the heating value of LPG is greater than that of gasoline.Keywords—Exhaust gas emission, spark ignition engine, throttle valve open
Analisis Perawatan Cutter Section Dredger Dengan Metode FMEA dan OEE
Authors: Hardiatama Intan , Yudah Norman Audi Erlangga Pradipta , Sidartawan Robertus , Basuki Hari Arbiantara , Kristianta Franciscus Xaverius 
Published: October 2022

The development of technology and industry is currently being followed by increasing demand from the industry for mining or mineral materials, one of which is tin. Indonesia as the second largest tin producing country in the world plays a very important role in the development of technology and industry in the world. In Indonesia, tin mining is carried out by several companies, one of which is PT Timah (Persero) Tbk. This study aims to determine the effectiveness of the KIP 17 dredger system is 77% and the critical components obtained are the shaft and joint on the pump. The results of the analysis using Fishbone diagrams show that the quality of bolts and nuts and sealsused is not good. With the results of the study, it is recommended to increase personnel, especially in maintenance activities, and to improve the quality of nuts, bolts, and seals so as not to cause water to enter which can damage core components. Keywords—Mining, FMEA, Dredger
Formulasi Sediaan Nanoemulsi Antiselulit Mengandung Kafein dan Minyak Biji Anggur (Vitis vinifera L.)
Authors: Priani Sani Ega , Wulansari Dinnanda Yussepina , Darusman Fitrianti 
Published: October 2022

Kafein adalah senyawa turunan metilxantin yang memiliki aktivitas antiselulit dengan mekanisme meningkatkan liposisis. Minyak biji anggur mengandung senyawa aktif oligoproantosianidin yang juga berfungsi sebagai antiselulit. Sistem nanoemulsi diketahui mampu meningkatkan penetrasi perkutan dari senyawa lipofilik ataupun hidrofilik seperti kafein. Penelitian ini bertujuan untuk mengembangkan sediaan nanoemulsi kafein mengandung minyak biji anggur dengan sifat fisik yang baik dan mengetahui persen penetrasi perkutan kafein dengan pengujian secara in vitro. Sediaan nanoemulsi dibuat menggunakan minyak biji anggur sebagai fasa minyak, tween 80 sebagai surfaktan, gliserin sebagai kosurfaktan, dengan variasi konsentrasi kafein sebagai zat aktif (1; 1,5; dan 2%). Sediaan dikarakterisasi dengan pengujian organoleptis, homogentitas, pH, viskositas, sifat alir, daya sebar, persen transmitan, distribusi ukuran globul, dan uji stabilitas fisik. Uji penetrasi perkutan dilakukan secara in vitro menggunakan sel difusi franz. Hasil penelitian menunjukkan bahwa sediaan nanoemulsi mengandung kafein 1% dengan minyak biji anggur 5% sebagai fasa minyak memiliki karakteristik fisik yang baik dengan penampilan transparan, homogen, sifat alir Newtonian, nilai transmitan 99,17 ± 0,06 %, dan ukuran globul 101 ± 13 nm. Jumlah kafein terpenetrasi pada menit ke-180 berdasarkan pengujian secara in vitro mencapai 88,947 ± 2,828 %. Sediaan nanoemulsi kafein memiliki karakteristik dan stabilitas fisik yang baik.
Factors Determining Consumers Intention to Shop Online in Greater Jakarta
Authors: Tanurahardja Lucy , Yudi  , Budi  , Rosidi Mohamad , Tirtomoyo Santoso Louis 
Published: October 2022

Online shopping is increasingly becoming a favorite activity for city dwellers who are smartphones users as a means to fulfil their necessities. Increasingly, people obtain their needs through online shopping and retailers are working hard to increase their sales by winning consumers to shop at their online stores. In this paper, we investigate factors affecting consumer’s intention in online shopping in Greater Jakarta area. These factors includes trust, perceived risk, reference group, behavioral control awareness, business competency, usefulness and convenience, brand image, and promotion. 272 respondents participated in this survey and their responses were documented using Likert scales. After data collection, a Factor Analysis used to identify correlations between variables and Regression Analysis techniques were used to identify significant factors. Our research findings reveal that out of eight factors, four factors affect consumers’ intention to shop online. These factors, starting from the most significant, are promotion, brand image, usefulness and convenience, and business competency
Analisis Faktor-Faktor Kepuasan dan Loyalitas Pelanggan Industri Kecantikan di Indonesia
Authors: Fitria Susiani  , Sampurno  , Haryani Hatta Iha 
Published: October 2022

Kontribusi loyalitas pelanggan akan mempercepat pertumbuhan pesat bagi suatu industri kecantikan. Karena itu diperlukan penelitian tentang faktor-faktor kepuasan, dan loyalitas pelanggan industri kecantikan di Indonesia dengan tujuan ingin mengetahui pengaruh kualitas pelayanan, harga, dan citra merek secara parsial terhadap kepuasan dan loyalitas pelanggan, serta pengaruh kepuasan terhadap loyalitas pelanggan. Populasi penelitian adalah pelanggan Klinik Hedtutu Skin Solution. Sampel sebanyak 143 secara purposive sampling. Analisis data secara SEM dengan program Lisrel. Hasil penelitian menerangkan bahwa adanya pengaruh antara variabel kualitas pelayanan, dan citra merek secara parsial terhadap kepuasan pelanggan, tetapi harga tidak berpengaruh terhadap kepuasan pelanggan. Harga, dan kepuasan pelanggan secara parsial berpengaruhi terhadap loyalitas pelanggan, tetapi kualitas pelayanan, dan citra merek tidak berpengaruh terhadap loyalitas.
Analisis Efektifitas Metode Konsumsi dan Alternatif Pengembangannya Dengan Balanced Scorecard di Klinik X
Authors: Gunawan Handy Sumarta 
Published: October 2022

Peranan persediaan pada perusahaan sangat penting untuk mendukung kegiatan operasional. Klinik X adalah salah satu klinik kecantikan di Jakarta yang memberikan pelayanan kepada masyarakat, sekitar 50% dari seluruh pendapatan klinik berasal dari pengelolaan perbekalan farmasi. Tujuan penelitian ini adalah mengetahui efektivitas metode konsumsi yang digunakan Klinik X dan menganalisis alternatif Inventory Management Klinik X yang lebih efektif dengan pendekatan Balanced scorecard. Penelitian ini merupakan penelitian Deskriptif, dengan desain penelitian eksploratif. Metode pengumpulan data melalui wawancara, observasi dan pengisian kuesioner. Hasil penelitian menunjukkan bahwa metode EOQ lebih efektif dalam manajemen persediaan di Klinik X dibandingkan dengan metode konsumsi, JIT maupun MMSL. Kemudian hasil pengukuran menggunakan Balanced scorecard diketahui metode alternatif lebih efektif dibandingkan dengan metode konsumsi dalam pengendalian persediaan untuk Klinik X, hal ini dapat dilihat dari adanya perbaikan pada perspektif keuangan dan perspektif pelanggan saat menggunakan metode EOQ dibandingkan dengan metode konsumsi. Sedangkan perspektif bisnis internal tidak mengalami perubahan, yaitu respon times yang masih di bawah target ketika menggunakan metode konsumsi maupun EOQ di Klinik X.
Pengaruh Sosial Media Terhadap Pembentukan Brand Awareness dan Purchase Intention Merek Sepatu Olahraga
Authors: Tedja Gavin , Felicia Abednego  
Published: October 2022

Media sosial sekarang ini sudah banyak mengubah bagaimana cara perusahaan melakukan promosi agar dapat membentuk consumer engagement dan brand awareness terhadap pelanggan sehingga menghasilkan purchase intention. Penelitian ini ditujukan untuk memahami seberapa besar pengaruh yang dapat dihasilkan oleh kualitas konten dan interaktivitas merek dalam media sosial yang akan mendukung pembentukan brand awareness dan juga purchase intention. Penelitian ini memanfaatkan pengolahan data structural equation modeling. Dalam penelitian ini tidak hanya sekedar melakukan penelitian media sosial terhadap purchase intention melainkan memanfaatkan juga motif hedonisme, motif utilitarian, consumer engagement dan brand awareness sebagai mediasi. Hasil dari penelitian ini menyatakan bahwa hanya kualitas konten yang mempengaruhi motif hedonisme dan utilitarian dari pengguna Instagram. Tentunya juga hal ini sangat mempengaruhi consumer engagement dan brand awareness yang dihasilkan sehingga terbentuklah purchase intention. Penelitian ini memanfaatkan objek sepatu olahraga karena objek tersebut sudah berkembang pesat di Indonesia juga diiringi dengan sepatu olahraga yang sudah menjadi gaya hidup bagi para konsumen. Dengan begini diharapkan merek-merek sepatu olahraga ini dapat lebih mnemperhatikan kualitas konten yang di sajikan di Instagram dan juga memperhatikan interaktivitas dengan pengguna sehingga bisa mendorong offline purchase intention.