bluuebunny/crossref_metadata_2025_split huggingface dataset:
One case of surgical treatment of coagulation factor XI deficiency complicated with esophageal cancer: a case report
Authors: Tian Yang , Zheng Zhaowei , Song Nannan , Wang Jun 
Published: December 2022

Abstract
Background: Coagulation factor XI (FXI) deficiency is an autosomal recessive hereditary disease with a low incidence. It usually occurs after surgery or trauma [1, 2]; Esophageal cancer is a common malignant tumor of the digestive tract and ranks sixth and fourth in the annual incidence and mortality of all malignant tumors in China [3]. But so far, surgery-based comprehensive treatment of esophageal cancer still dominates [4].
Case presentation: We report a case of a patient with FXI deficiency and lower esophageal squamous cell carcinoma in our hospital.
Conclusions: The encouraging perioperative outcome enables us to have a deeper understanding of surgical treatment strategies for patients with FXI deficiency.
Maternal E-Cigarette Use Can Disrupt Postnatal Blood-Brain Barrier (BBB) Integrity and Deteriorates Motor, Learning and Memory Function: Influence of Sex and Age
Authors: Archie Sabrina Rahman , Sifat Ali Ehsan , Zhang Yong , Villalba Heidi , Sharma Sejal , Nozohouri Saeideh , Abbruscato Thomas 
Published: December 2022

Abstract
Electronic nicotine delivery systems (ENDS), also commonly known as electronic cigarettes (e-cigs) are considered in most cases as a safer alternative to tobacco smoking and therefore have become extremely popular among all age groups and sex. It is estimated that up to 15% of pregnant women are now using e-cigs in the US which keeps increasing at an alarming rate. Harmful effects of tobacco smoking during pregnancy are well documented for both pregnancy and postnatal health, however limited preclinical and clinical studies exist to evaluate the long-term effects of prenatal e-cig exposure on postnatal health. Therefore, the aim of our study is to evaluate the effect of maternal e-cig use on postnatal blood-brain barrier (BBB) integrity and behavioral outcomes of mice of varying age and sex. In this study, pregnant CD1 mice (E5) were exposed to e-Cig vapor (2.4% nicotine) until postnatal day (PD) 7. Weight of the offspring was measured at PD0, PD7, PD15, PD30, PD45, PD60 and PD90. The expression of structural elements of the BBB, tight junction proteins (ZO-1, claudin-5, occludin), astrocytes (GFAP), pericytes (PDGFRβ) and the basement membrane (laminin α1, laminin α4), neuron specific marker (NeuN), water channel protein (AQP4) and glucose transporter (GLUT1) were analyzed in both male and female offspring using Western blot and immunofluorescence. Estrous cycle was recorded by vaginal cytology method. Long‐term motor and cognitive functions were evaluated using open field test, novel object recognition test (NORT) and morris water maze test (MWMT) at adolescence (PD 40–45) and adult (PD 90–95) age. In our study, significantly reduced expression of tight junction proteins and astrocyte markers were observed in male and female offspring until PD 90 (P < 0.05). Additionally, prenatally e-cig exposed adolescent and adult offspring showed impaired locomotor, learning, and memory function compared to control offspring (P < 0.05). Our findings suggest that prenatal e-cig exposure induces long-term neurovascular changes of neonates by disrupting postnatal BBB integrity and worsening behavioral outcomes.
Preselection of QTL markers enhances accuracy of genomic selection in Norway spruce
Authors: Chen Zhi-Qiang , Klingberg Adam , Hallingbäck Henrik R. , Wu Harry X. 
Published: December 2022

Abstract

Genomic prediction (GP) or genomic selection is a method to predict the accumulative effect of all quantitative trait loci (QTLs) effects by capturing the linkage disequilibrium between markers and QTLs. Thus, marker preselection is considered a promising method to capture Mendelian segregation effects, especially for an oligogenic trait. Using QTLs detected in the genome-wide association study (GWAS) could improve genomic prediction, including informative marker selection and adding a QTL with the largest effect size as a fixed effect. Here, we performed GWAS and genomic selection studies in a population with 904 clones from 32 full-sib families using a newly developed 50k SNP Norway spruce array. In total, GWAS identified 41 SNPs associated with budburst stage (BB) and the SNP with the largest effect size explained 5.1% of the phenotypic variation (PVE). For the other five traits like growth and wood quality traits, only 2–13 SNPs were detected and PVE of the strongest effects ranged from 1.2–2.0%. GP with approximately 100 preselected SNPs based on the smallestp-values from GWAS showed the largest predictive ability (PA) for the oligogenic trait BB. But for the other polygenic traits, approximate 2000–4000 preselected SNPs, indicated by the smallest Akaike information criterion to offer the best model fit, still resulted in PA being similar to that of GP models using all markers. Analyses on both real-life and simulated data also showed that the inclusion of a large QTL SNP in the model as a fixed effect could improve PA and accuracy of GP provided that the PVE of the QTL was ≥ 2.5%.
The Relationship between Type D Personality and Primary Narrow Angle &amp; Primary Angle Closure Glaucoma
Authors: Wang Qinye , Hu Yuedong , Zhang Xinyue , Wang Jue 
Published: December 2022

Abstract
Purpose: To investigate the relationship of type D personality and primary narrow angle and primary angle closure glaucoma.
Methods: A cross-sectional study was performed in 110 patients with primary narrow angle admitted to the Department of Ophthalmology, the First Affiliated Hospital of China Medical University from June to October 2021. Among them, 49 patients had a history of glaucoma attack or visual field changes, and 61 patients had no history of glaucoma attack and visual field changes. Forty-nine age-related cataract patients with normal anterior chamber depth were included as control group. The demographic characteristics and ophthalmic examination results were collected, and all subjects were evaluated by type D scale-14, self-rating anxiety scale and self-rating depression scale.
Results: There were 60 subjects (54.5%) had type D personality in primary narrow angle patients, and 5 subjects (10.2%) in control group; in primary narrow angle group, 37 patients (75.5%) had type D personality among primary angle closure glaucoma patients, and 23 patients (37.7%) in patients without history of glaucoma attack or visual field changes. The results of ordered logistic regression analysis showed that type D personality increased the risk of angle-closure glaucoma and primary narrow angle (OR=5.730，95%CI 2.596-12.648，p<0.001).
Conclusions: TDP and anxiety are significantly associated with PACG, TDP has a certain correlation with PNA.
Modeling the Water Pollutants Nonlinear-based Problems Using Optimized Intelligence Techniques and Determination of Uncertainties
Authors: Poursaeid Mojtaba , Poursaeed AmirHossein 
Published: December 2022

Abstract
Along with the global population growth, the human need for safe drinking water sources has increased. With global warming, the water challenge is perhaps the most crucial challenge for the world community. At the same time, scientific methods are one of the best tools to help humanity. Considering that in many natural phenomena, it is possible to describe them based on complex relationships, it is almost impossible to solve them analytically and mathematically. Therefore, it is necessary to use methods with the ability, accuracy, and high speed to justify nonlinear relationships. One of these methods is Artificial Intelligence (AI). This research used the Extreme Learning Machine (ELM) model and Genetic Algorithm (GA) to create a new hybrid model Genetic Extreme Learning Machine (GAELM). AI and hybrid models were used to simulate and predict the water quality parameter changes. The study area in this work was the Colorado River Basin in the United States. The desired qualitative parameters were Electrical Conductivity (EC) and Dissolved Oxygen (DO). Finally, using seven approaches, the models' performance was compared. The results showed that the best simulation related to the GAELM hybrid model in the EC parameter modeling with indices RMSE and R2 equal to 0.1304, and 0.8619, respectively. Also, the ELM model was ranked in second place in accuracy. Based on the uncertainty analysis (UA-WSM) results, the GAELM(EC) model was the most accurate, with the minimum average prediction error equal to 0.01.
Simultaneous Assessment and Training of an Upper-Limb Amputee using Incremental Machine-Learning-based Myocontrol: A Single-Case Experimental Design
Authors: Nowak Markus , Bongers Raoul M. , Sluis Corry K. van der , Albu-Schäffer Alin , Castellini Claudio 
Published: December 2022

Abstract
Background: Machine-learning-based myocontrol of prosthetic devices suffers from a high rate of abandonment due to dissatisfaction with the training procedure and with the reliability of day-to-day control. Incremental myocontrol is a promising approach as it allows on-demand updating of the system, thus enforcing continuous interaction with the user. Nevertheless, a long-term study assessing the efficacy of incremental myocontrol is still missing, partially due to the lack of an adequate tool to do so. In this work we close this gap and report about a person with upper-limb absence who learned to control a dexterous hand prosthesis using incremental myocontrol through a novel functional assessment protocol called SATMC (Simultaneous Assessment and Training of Myoelectric Control).
Methods: The participant was fitted with a custom-made prosthetic setup with a controller based on Ridge Regression with Random Fourier Features (RR-RFF), a non-linear, incremental machine learning method, used to build and progressively update the myocontrol system. During a 13-month user study, the participant performed increasingly complex daily-living tasks, requiring fine bimanual coordination and manipulation with a multi-fingered hand prosthesis, in a realistic laboratory setup. The SATMC was used both to compose the tasks and continually assess the participant’s progress. Patient satisfaction was measured using Visual Analog Scales.
Results: Over the course of the study, the participant progressively improved his performance both objectively, e.g., the time required to complete each task became shorter, and subjectively, meaning that his satisfaction improved. The SATMC actively supported the improvement of the participant by progressively increasing the difficulty of the tasks in a structured way. In combination with the incremental RR-RFF allowing for small adjustments when required, the participant was capable of reliably using four actions of the prosthetic hand to perform all required tasks at the end of the study. Conclusions: Incremental myocontrol enabled an upper-limb amputee to reliably control a dexterous hand prosthesis while providing a subjectively satisfactory experience. The SATMC can be an effective tool to this aim.
Epigenetic in Obstructive Sleep Apnea: miR-145-5p targets DNMT3A and regulates DNA methylation homeostasis in upper airway muscle
Authors: Yang Minlan , Ming Xiaoping , Yang Xiuping , Cai Weisong , Shi Zhenxiang , Wu Jianghao , Chen Xiong 
Published: December 2022

Abstract

Background Epigenetic modifications, especially DNA methylation and post-transcriptional miRNA-mediated regulation, are closely related to the occurrence and development of obstructive sleep apnea (OSA). Our previous study found that reduced expression of miR-145-5p may be a serological early warning marker for OSA diagnosis alone, but the underlying mechanism is unknown. Objectives To explore the underlying mechanism of miR-145-5p affects DNA methylation homeostasis in upper airway muscle. Methods Primary genitourinary muscle cells were extracted from Sprague-Dawley rats and cultured under intermittent hypoxic conditions for 12h to mimic the OSA pattern. The targeted regulatory relationship between miR-145-5p and DNMT3A was confirmed by bioinformatics predictions and dual luciferase reports. At last, we performed Whole Genome Bisulfite Sequencing (WGBS) in miR-145-5p overexpression genioglossus cells and the negative control cells (n = 3, each group). Results We found that intermittent hypoxia can increase the expression of DNMT3A in the genioglossus cells, and miR-145-5p regulates the expression and transcriptional activity of DNMT3A. WGBS results showed that 5738 CpG gDMR genes and 1006 CpG gDMR promoter-associated genes were differentially methylated. Gene Ontology enrichment analysis of CpG gDMR genes revealed that they were mainly involved in the regulation of plasma membrane part, cell projection, and plasma membrane-bounded cell projection. KEGG pathway enrichment analysis revealed that they were mainly involved in the MAPK signaling pathway, cAMP pathway, and PI3K/AKT pathway. Conclusions Our findings contribute to growing evidence that exposure to chronic intermittent hypoxia alters DNA methylation patterns in patients with OSA, and present the first global DNA methylation description of the impact of chronic intermittent hypoxia exposure on upper airway muscle in vitro. In particular, our results suggest that miR-145-5p regulates DNA methylation homeostasis in upper airway muscle by targeting DNMT3A, which provides new knowledge to understand the potential mechanism of OSA occurrence and development.
The nexus between entrepreneurship and property rights: Role of legal origin in entrepreneurship, property rights, and economic growth
Authors: Tomita Yosuke , Kimura Akinori 
Published: December 2022

Abstract
Differences in legal origins result in varieties of capitalism, and this may influence the impact of property rights on entrepreneurship and the relationship between entrepreneurship and economic growth. Therefore, we explored the relationship between entrepreneurship, property rights, and economic growth by examining macro data from 51 countries from 2001 to 2020 and classifying the countries based on their legal origins (English, French, German, and Scandinavian). We obtained data on entrepreneurship from the Global Entrepreneurship Monitor, a research consortium developed by Babson College and the London Business School. The results indicated that entrepreneurship is associated with economic growth in civil law countries rather than in common law countries. In addition, the form of the function between entrepreneurship and property rights differs depending on the legal origin. We observed a rising trend in the association between entrepreneurship and property rights for countries with English and German legal origins, while we noted a gradual quadratic function in the bell curve trend for countries with French legal origin. As for countries with Scandinavian legal origin, we found a negative linear relationship between property rights and entrepreneurial activity.
JEL: L26, M13, P14, K15, O47
Prediction of prognosis of Pancreatic adenocarcinoma based on anoikis-related genes and Multi-omics Verification
Authors: Zhang Jin , Li Xuesong , Zhang Zhongmin , Shen Yuxiang , Li Guanghao , Wang Guowen , Duan Yuansheng 
Published: December 2022

Abstract
Background
Anoikis is a specific form of apoptosis caused by the detachment of cells from the extracellular matrix. Several studies have reported that anoikis-related genes played an important role in the development of cancer.
Methods
Univariate Cox regression analysis and lasso regression analysis for anoikis-related genes were utilized to establish a prognostic model for pancreatic adenocarcinoma in the TCGA database. We also performed univariate and multifactorial Cox analyses of protein sequencing results for TCGA pancreatic adenocarcinoma. We then performed a cluster analysis based on prognostic model genes and explored the somatic mutations in various types of patients. Besides, we explored the difference in immune infiltration between the high-risk and low-risk groups. At last, the expression of screened genes was verified by real-time quantitative PCR (qRT-PCR).
Results
We found that many anoikis-related genes are associated with pancreatic adenocarcinoma prognosis. Finally, we screened seven genes (MET, DYNLL2, CDK1, TNFSF10, PIP5K1C, MSLN, GKN1). We also found that EGFR and MMP2 proteins have an important impact on the prognosis of pancreatic adenocarcinoma. According to the seven prognostic gene clustering analyses, it can be clearly divided into three categories, and the somatic mutations of patients in the three categories differed significantly. There was also a significant difference between the high-risk and low-risk groups in terms of immune infiltration. All genes were are highly expressed in tumor cells (AS, CF) than that in normal cell (HPDE).
Conclusion
Through our study, we found that anoikis had a very important effect on the development of pancreatic adenocarcinoma. Our prognostic model based on seven anoikis-related genes has good predictive performance. KRAS, P53 and CDKN2A mutations also have important effects on the prognosis of pancreatic adenocarcinoma.
Health Promotion and Disease Prevention Registries in the E.U.: A cross country comparison
Authors: Rossmann Christin , Krnel Sandra Radoš , Kylanen Marika , Lewtak Katarzyna , Tortone Claudio , Ragazonni Paola , Grasso Mara , Maassen Alison , Costa Luciana , Dale Djoeke van 
Published: December 2022

Abstract
Background: Health promotion and disease prevention programme registries (HPPR), or ‘best practice portals’, serve as entry points and practical repositories which enable decision-makers to have easy access to (evidence-based) practices. However, there is limited knowledge of differences or overlaps in the functioning of current national HPPRs in Europe, the context and circumstances in which these HPPRs were developed, and the mechanisms utilised by each HPPR for assessment, classification and quality improvement of included practices.
The aim of the study was to prepare an overview of different approaches in several national HPPRs and the EU Best Practice Portal (EU BPP) as well as to identify commonalities and differences among core characteristics of the HPPRs.
Methods: A descriptive comparison – focused on six European countries with an existing or recently developed/implemented national HPPR and the EU BPP – was conducted to create a comparative overview. Coding mechanisms were used to identify commonalities and differences, and data management, collection and building consensus were performed during EuroHealthNet Thematic Working Group meetings.
Results: All HPPRs offer a broad range of health promotion and disease prevention practices and are designed to support practitioners, policy makers and researchers in selecting practices. Almost all HPPRs have an assessment process in place or planned, requiring the application of assessment criteria that differ among the HPPRs. While all HPPRs collect and share recommendable practices, others have implemented further measures to improve the quality of submitted practices. Different dissemination tools and strategies are employed to promote the use of the HPPRs, including social media, newsletters and publications as well as capacity building workshops for practice owners or technical options to connect citizens/patients with local practices.
Conclusions:
Collaboration between HPPRs (at national and EU levels) is appreciated, especially in terms of using consistent terminology to avoid misinterpretation and facilitate cross-country comparison, as well as to facilitate discussion on the adaption of assessment criteria by national HPPRs. Greater efforts are needed to promote the actual implementation and transfer of practices at national level in order to address public health challenges with proven and effective practices.
Radiographic airway abnormalities in untreated early rheumatoid arthritis are associated with peripheral neutrophil activation
Authors: Selldén Tilia , Mårdh Carina Kärrman , Joelsson Martin , Vikgren Jenny , Johnsson Åse , Larsson Gunilla , Glinatsi Daniel , Stubendorff Kajsa , Svensson Karin , Gjertsson Inger , Rudin Anna , Lundell Anna-Carin , Ekwall Anna-Karin Hultgård 
Published: December 2022

Abstract
Background:
The role of the lung for the initiation and progression of rheumatoid arthritis (RA) is still unclear. Up to 10% of RA patients develop severe treatment resistant lung disease. Understanding early disease mechanisms is of great importance. The objective of this study was to determine whether there is an association between peripheral neutrophil phenotypes and presence of pulmonary abnormalities (PA) on chest high-resolution computed tomography (HRCT) in untreated early RA (ueRA).
Methods:
Clinical data and blood were collected, and HRCT performed at diagnosis on 30 consecutive anti-citrullinated protein antibody (ACPA) and/or rheumatoid factor (RF) positive ueRA patients. HRCTs were evaluated for the presence and extent of RA-associated parenchymal, airway and/or pleural abnormalities. Expression of phenotype markers on neutrophils were determined by flow cytometry. Levels of calprotectin, ACPA and RF were measured using immunoassays.
Results:
The frequency of having any PA was 60%. Airway abnormalities were present in 50%, parenchymal nodules in 43% and interstitial lung abnormalities (ILA) in 10%. Unsupervised multivariate factor analysis showed clustering of any PA with neutrophil activation, parameters of inflammation and RF titres. In univariate analysis, the patients with PA displayed significantly increased CD11b and decreased CD62L expression on neutrophils (1.2-fold, p = 0.014; 0.8-fold, p = 0.012) indicating activation, and significantly increased RF IgM titre and CRP (5.7-fold, p = 0.0025; 2.3-fold, p = 0.0035) as compared to no PA. Titres of RF, but not ACPA, correlated with expression of the neutrophil activation marker CD11b. A stratified analysis demonstrated that airway involvement was the PA subtype with the strongest association with neutrophil activation.
Conclusion:
We report a strong association between radiographic airway findings and activation of circulating neutrophils in early RA supporting a role of innate immunity and the lung in disease onset. Our results also indicate different contributions of RF and ACPA in the RA pathogenesis.