bluuebunny/crossref_metadata_2025_split huggingface dataset:
Wet depositions of cations in forests across NADP, EMEP, and EANET monitoring networks over the last two decades
Authors: Chang Chung-Te , Yang Ci-Jian , Huang Jr-Chuan 
Published: November 2022

AbstractStudies focused on emissions and acid deposition of sulfur (S) and nitrogen (N) and the consequent precipitation acidity have a long history. However, atmospheric depositions of cations play a critical role in buffering precipitation acidity, and providing cationic nutrients for vegetation growth lacks sufficient studies equally. The spatiotemporal patterns of cation depositions and their neutralization potential across broad scales remain unclear. Through synthesizing the long-term data in forest sites (n = 128) derived from three monitoring networks (NADP in Northern America, EMEP in Europe, and EANET in East Asia) on wet deposition of cations (Na+, NH4-N, K+, Mg2+, and Ca2+), this study assesses the temporal changes and spatial patterns of cation depositions and their neutralization potential over the last two decades. The results showed that the depositions of cationic nutrients were considerably higher in EANET compared to NADP and EMEP. The depositions of sea salt-associated sodium exhibited a significant transition from marine (> 15 kg ha−1 year−1) to inland (< 3.0 kg ha−1 year−1) forest sites attributable to the precipitation quantity and influences of sea spray. The higher emissions of NH3and particulate matter in East Asia explained the higher cation depositions in EANET than NADP and EMEP. The annual trends of cations revealed that only 20–30% of the forest sites showed significant changing trends and the sites widely spread across the three networks. Possibly, base cation (BC) deposition has reached a low and stable condition in NADP and EMEP, while it has high spatial heterogeneity in the temporal change in EANET. The difference in BC deposition among the three networks reflects their distinct development of economy. Our synthesis indicates that the annual trends of neutralization factor (NF) in NADP can be explained by the declining of acid potential (AP), not by neutralization potential (NP) as BC deposition has been stably low over the past two decades. Whereas, the concurrent decreases of AP and NP in EMEP or plateau period of both AP and NP in EANET have come to a standstill of acid neutralizing capacity.
Hippocratic Oaths for Mathematicians?
Authors: Rittberg Colin Jakob 
Published: November 2022

AbstractIn this paper I ask whether mathematicians should swear an oath similar to the Hippocratic oath sworn by some medical professionals as a means to foster morally praiseworthy engagement with the ethical dimensions of mathematics. I individuate four dimensions in which mathematics is ethically charged: (1) applying mathematical knowledge to the world can cause harm, (2) participation of mathematicians in morally contentious practices is an ethical issue, (3) mathematics as a social activity faces relevant ethical concerns, (4) mathematical knowledge itself may be ethically charged. I present a conceptual framework for oaths and discuss some empirical results on the effectiveness of oath-taking to foster morally praiseworthy behaviour. My findings suggest that enforcing oath-taking practices in mathematics is not currently a suitable means to foster ethically praiseworthy behaviour amongst mathematicians. Oaths can, however, provide needed edifying narratives about how to act ethically when acting as a mathematician.
Electrocardiographic imaging in the atria
Authors: Hernández-Romero Ismael , Molero Rubén , Fambuena-Santos Carlos , Herrero-Martín Clara , Climent Andreu M. , Guillem María S. 
Published: November 2022

Abstract
The inverse problem of electrocardiography or electrocardiographic imaging (ECGI) is a technique for reconstructing electrical information about cardiac surfaces from noninvasive or non-contact recordings. ECGI has been used to characterize atrial and ventricular arrhythmias. Although it is a technology with years of progress, its development to characterize atrial arrhythmias is challenging. Complications can arise when trying to describe the atrial mechanisms that lead to abnormal propagation patterns, premature or tachycardic beats, and reentrant arrhythmias. This review addresses the various ECGI methodologies, regularization methods, and post-processing techniques used in the atria, as well as the context in which they are used. The current advantages and limitations of ECGI in the fields of research and clinical diagnosis of atrial arrhythmias are outlined. In addition, areas where ECGI efforts should be concentrated to address the associated unsatisfied needs from the atrial perspective are discussed.
Graphical abstract
Ethics and Genomic Editing Using the Crispr-Cas9 Technique: Challenges and Conflicts
Authors: Lorenzo David , Esquerda Montse , Palau Francesc , Cambra Francisco J. , Bioética Grup Investigació en 
Published: November 2022

Abstract
The field of genetics has seen major advances in recent decades, particularly in research, prevention and diagnosis. One of the most recent developments, the genomic editing technique Clustered regularly interspaced short palindromic repeats (CRISPR)-Cas9, has opened the possibility for genetic therapies through genome modification. The technique marks an improvement on previous procedures but poses some serious ethical conflicts. Bioethics is the discipline geared at finding answers to ethical challenges posed by progress in medicine and biology and examining their repercussions for society. It can also offer a conceptualization of these ethical dilemmas. The aim of this paper is to offer a map of the ethical dilemmas associated with this technique by way of a critical analysis of current literature. The main issues can be grouped in four areas: efficacy and security; the types of cells which can be targeted by the technique (somatic, embryonic and gametes); the goal of the therapy; and accessibility and justice.
Transcranial alternating current stimulation ameliorates emotional attention through neural oscillations modulation
Authors: Liu Shuang , He Yuchen , Guo Dongyue , Liu Xiaoya , Hao Xinyu , Hu Pengchong , Ming Dong 
Published: November 2022

Abstract
Background
Numerous clinical reports have suggested that psychopathy like schizophrenia, anxiety and depression is accompanied by early attentional abnormalities in emotional processing. Recently, the efficacy of transcranial alternating current stimulation (tACS) in changing emotional functioning has been repeatedly observed and demonstrated a causal relationship between endogenous oscillations and emotional processing.

Aims
Up to now, tACS effects on emotional attention have not yet been tested. To assess such ability, we delivered active-tACS at individual alpha frequency (IAF), 10 Hz or sham-tACS for 7 consecutive days in the bilaterally dorsolateral prefrontal cortex (dlPFC) to totally 79 healthy participants.

Results
IAF-tACS group showed significant alpha entrainment at-rest, especially in open state around stimulation area and showed an obvious advantage compared to 10 Hz-tACS. Event-related potential revealed a significant larger P200 amplitude after active-tACS and IAF group showed wider range of emotions than 10 Hz-tACS, indicating the attentional improvement in facial emotion processing. A notable positive correlation between alpha power and P200 amplitude provided an electrophysiological interpretation regarding the role of tACS in emotional attention modulation instead of somatosensory effects.

Conclusion
These results support a seminal outcome for the effect of IAF-tACS on emotional attention modulation, demonstrating a feasible and individual-specific therapy for neuropsychiatric disorders related to emotion processing, especially regarding oscillatory disturbances.
Resting state fMRI analysis of pseudobulbar affect in Amyotrophic Lateral Sclerosis (ALS): motor dysfunction of emotional expression
Authors: Trojsi Francesca , Di Nardo Federica , D’Alvano Giulia , Caiazzo Giuseppina , Passaniti Carla , Mangione Antonella , Sharbafshaaer Minoo , Russo Antonio , Silvestro Marcello , Siciliano Mattia , Cirillo Mario , Tedeschi Gioacchino , Esposito Fabrizio 
Published: November 2022

Abstract
Pseudobulbar affect (PBA), referring to exaggerated or inappropriate episodes of laughing and/or crying without an apparent motivating stimulus, has been mainly attributed to bilateral degeneration of corticobulbar tracts. We aimed at exploring brain functional connectivity (FC) correlates of PBA in patients with amyotrophic lateral sclerosis (ALS), the most common motor neuron disease, frequently associated with PBA. Resting state functional MRI (RS-fMRI) independent component (ICA) and seed-based analyses and voxel-based morphometry (VBM) whole-brain analysis were performed on 27 ALS patients (13 with PBA; 14 without PBA) and 26 healthy controls (HC), for investigating functional and structural abnormalities in ALS patients compared to HC and in patients with PBA compared to patients without PBA. Between-patient analysis revealed different FC patterns, especially regarding decreased FC in several areas of cognitive (default mode, frontoparietal, salience) and sensory-motor networks in patients with PBA compared to those without PBA. However, no significant differences were found in gray matter atrophy. Seed-based analysis showed increased FC between middle cerebellar peduncles and posterior cingulate cortex and decreased FC between middle cerebellar peduncles and left middle frontal gyrus in patients with PBA compared to patients without PBA. Our findings suggest that some alterations of fronto-tempo-parietal-cerebellar circuits could be related to PBA in ALS. In particular, the abnormal FC between cerebellum and posterior cingulate cortex and left middle frontal gyrus in patients with PBA compared to patients without PBA highlights a crucial role of the cerebellum in regulating emotion expression in patients with ALS.
Efficiency of European oil companies: an empirical analysis
Authors: Sanchez-Robles Blanca , Herrador-Alcaide Teresa C. , Hernández-Solís Montserrat 
Published: November 2022

Abstract
We explore the efficiency in the oil industry employing a sample of around 300 companies operating in Europe over 2010–2019. We construct efficiency scores by means of DEA non-parametric techniques. Average efficiency in the sample is modest, 0.27, and decreasing over time. We examine the association of efficiency with economic and financial variables. Results suggest that size is closely associated to efficiency. Large (in the top 10th percentile of income) and very small firms are more efficient, ceteris paribus, whereas medium size and small firms exhibit lower levels of efficiency. Firms which have strived more to implement sustainable technologies and cut greenhouse emissions are more efficient too. Increases in employee costs and decreases in financial solvency jeopardize efficiency, which displays a positive correlation with economic activity and oil prices. As a robustness test, we have repeated the exercise by means of the Simar-Wilson methodology, which confirms our main results regarding efficiency levels and trends and correlations with other variables. Our findings suggest that an industry consolidation is foreseeable in the future.
Dimensions of uncertainty communication: What is conveyed by verbal terms and numeric ranges
Authors: Teigen Karl Halvor 
Published: November 2022

AbstractThe paper reviews two strands of research on communication of uncertainty that usually have been investigated separately: (1) Probabilities attached to specific outcomes, and (2) Range judgments. Probabilities are sometimes expressed by verbal phrases (“rain is likely”) and at other times in a numeric format (“70% chance of rain”), whereas range judgments describe the potential amounts expected (“1–4 mm of rain”). Examination of previous research shows that both descriptions convey, in addition to the strength of expectations, pragmatic information about the communicative situation. For instance, so-called verbal probability expressions (VPE), aslikely,unlikely, a chance,ornot certaingive some, albeit vague, probabilistic information, but carry in addition an implicit message about the sources of uncertainty, the outcome’s valence and severity, along with information about the speakers’ attitudes and their communicative intentions. VPEs aredirectionalby drawing attention either to an outcome’s occurrence (“it is possible”) or to its non-occurrence (“it is doubtful”). In this sense they may be more informative than numbers. Uncertainties about outcomes in a distribution (continuous quantities) are alternatively expressed as interval estimates. The width of such intervals can function as a cue to credibility and expertise. Incomplete, one-sided intervals, where only one boundary is stated, imply directionality. “More than 100 people” suggests a crowd, while “less than 200” implies a shortfall. As with VPEs, directionally positive intervals are more frequent, and perhaps more neutral than negative ones. To convey expectancies and uncertainty in a balanced way, communicators may have to alternate between complementary frames.
The Role of Ultrasound in the Evaluation of Elbow Medial Ulnar Collateral Ligament Injuries in Throwing Athletes
Authors: Sutterer Brian J. , Boettcher Brennan J. , Payne Jeffrey M. , Camp Christopher L. , Sellon Jacob L. 
Published: November 2022

Abstract
Purpose of Review
Although ultrasound (US) imaging is commonly used to evaluate the elbow medial ulnar collateral ligament (mUCL) in throwing athletes, significant technical heterogeneity exists in the published literature and in practice. This has resulted in variable and often ambiguous US diagnostic criteria for mUCL injury. This review summarizes the literature on sonographic evaluation of the mUCL and outlines recommendations for consistent descriptive terminology, as well as future clinical and research applications.

Recent Findings
Both acute and chronic throwing loads in overhead athletes cause the mUCL to become thicker and more lax on stress testing, and these changes tend to revert after a period of prolonged rest. Stress US (SUS) can aid in the diagnosis of mUCL tears and may help identify athletes at risk of mUCL injury. Variability exists in terminology, elbow flexion angle, amount of stress applied, and technique of stress testing. Recent studies have suggested an injured elbow stress delta (SD—change in ulnohumeral joint (UHJ) space with valgus stress) of 2.4 mm and a stress delta difference (SDD—side-side difference in SD) of 1 mm each denote abnormal UHJ laxity due to mUCL injury.

Summary
US imaging is a powerful and widely accessible tool in the evaluation elbow mUCL injuries. Sonologists should consider how their US techniques compare with published methods and use caution when applying diagnostic criteria outside of those circumstances. Currently, an SD of 2.4 mm and an SDD of 1 mm provide the best diagnostic accuracy for mUCL tears requiring surgery. Finally, preliminary work suggests that shear wave elastography may be helpful in evaluating the biomechanical properties of the mUCL, but additional research is needed.
Interactions Between Astrocytes and Oligodendroglia in Myelin Development and Related Brain Diseases
Authors: Hu Xuelian , Yu Guangdan , Liao Xiang , Xiao Lan 
Published: November 2022

AbstractAstrocytes (ASTs) and oligodendroglial lineage cells (OLGs) are major macroglial cells in the central nervous system. ASTs communicate with each other through connexin (Cx) and Cx-based network structures, both of which allow for quick transport of nutrients and signals. Moreover, ASTs interact with OLGs through connexin (Cx)-mediated networks to modulate various physiological processes in the brain. In this article, following a brief description of the infrastructural basis of the glial networks and exocrine factors by which ASTs and OLGs may crosstalk, we focus on recapitulating how the interactions between these two types of glial cells modulate myelination, and how the AST-OLG interactions are involved in protecting the integrity of the blood-brain barrier (BBB) and regulating synaptogenesis and neural activity. Recent studies further suggest that AST-OLG interactions are associated with myelin-related diseases, such as multiple sclerosis. A better understanding of the regulatory mechanisms underlying AST-OLG interactions may inspire the development of novel therapeutic strategies for related brain diseases.
Development and validation of a ferroptosis-related lncRNAs signature to predict prognosis and microenvironment for melanoma
Authors: Ping Shuai , Gong Ruining , Lei Ke , Qing Gong , Zhang Guangheng , Chen Jianghai 
Published: November 2022

AbstractFerroptosis plays an important role in cancer. However, studies about ferroptosis-related lncRNAs (FRLs) in skin cutaneous melanoma (SKCM) are scarce. Moreover, the relationship between prognostic FRLs and tumor microenvironment (TME) in melanoma remains unclear. This study investigates the potential prognostic value of FRLs and their association with TME in SKCM. The RNA-sequencing data of SKCM were downloaded from The Cancer Genome Atlas (TCGA) database. Melanoma patients were randomly divided into training and testing groups in a 1:1 ratio. A signature composed of 19 FRLs was developed by the least absolute shrinkage and selection operator (LASSO) regression analysis to divide patients into a low-risk group with a better prognosis and a high-risk group with a poor prognosis. Multivariate Cox regression analysis suggested that the risk score was an independent prognostic factor. The Area Under Curve (AUC) value of the risk score reached 0.768 in the training group and 0.770 in the testing group. Subsequent analysis proved that immune-related signaling pathways were significantly enriched in the low-risk group. The tumor immune cell infiltration analysis demonstrated that melanoma in the high-risk group tended to be immunologically “cold”. We identified a novel FRLs signature which could accurately predict the prognosis of patients with melanoma.
Radiomics based on readout-segmented echo-planar imaging (RS-EPI) diffusion-weighted imaging (DWI) for prognostic risk stratification of patients with rectal cancer: a two-centre, machine learning study using the framework of predictive, preventive, and personalized medicine
Authors: Liu Zonglin , Wang Yueming , Shen Fu , Zhang Zhiyuan , Gong Jing , Fu Caixia , Shen Changqing , Li Rong , Jing Guodong , Cai Sanjun , Zhang Zhen , Sun Yiqun , Tong Tong 
Published: November 2022

Abstract
Background
Currently, the rate of recurrence or metastasis (ROM) remains high in rectal cancer (RC) patients treated with the standard regimen. The potential of diffusion-weighted imaging (DWI) in predicting ROM risk has been reported, but the efficacy is insufficient.

Aims
This study investigated the potential of a new sequence called readout-segmented echo-planar imaging (RS-EPI) DWI in predicting the ROM risk of patients with RC using machine learning methods to achieve the principle of predictive, preventive, and personalized medicine (PPPM) application in RC treatment.

Methods
A total of 195 RC patients from two centres who directly received total mesorectal excision were retrospectively enrolled in our study. Machine learning methods, including recursive feature elimination (RFE), the synthetic minority oversampling technique (SMOTE), and the support vector machine (SVM) classifier, were used to construct models based on clinical-pathological factors (clinical model), radiomic features from RS-EPI DWI (radiomics model), and their combination (merged model). The Harrell concordance index (C-index) and the area under the time-dependent receiver operating characteristic curve (AUC) were calculated to evaluate the predictive performance at 1 year, 3 years, and 5 years. Kaplan‒Meier analysis was performed to evaluate the ability to stratify patients according to the risk of ROM.

Findings
The merged model performed well in predicting tumour ROM in patients with RC at 1 year, 3 years, and 5 years in both cohorts (AUC = 0.887/0.813/0.794; 0.819/0.795/0.783) and was significantly superior to the clinical model (AUC = 0.87 [95% CI: 0.80–0.93] vs. 0.71 [95% CI: 0.59–0.81], p = 0.009; C-index = 0.83 [95% CI: 0.76–0.90] vs. 0.68 [95% CI: 0.56–0.79], p = 0.002). It also had a significant ability to differentiate patients with a high and low risk of ROM (HR = 12.189 [95% CI: 4.976–29.853], p < 0.001; HR = 6.427 [95% CI: 2.265–13.036], p = 0.002).

Conclusion
Our developed merged model based on RS-EPI DWI accurately predicted and effectively stratified patients with RC according to the ROM risk at an early stage with an individualized profile, which may be able to assist physicians in individualizing the treatment protocols and promote a meaningful paradigm shift in RC treatment from traditional reactive medicine to PPPM.
Engaging rurality in Australian education research: addressing the field
Authors: Roberts Philip , Downes Natalie , Reid Jo-Anne 
Published: November 2022

AbstractIn this paper, we examine engagement with ‘the rural context’ in Australian education research, focussing on the implications of the signifier ‘rural’—in terms of its inclusion or absence. A review of Australian research literature in rural education indicates that the term ‘rural’ and its synonyms are more often used to denote assumptions of a generalised and predetermined ‘context’ for research than to think about its meaning. We present our findings here and discuss the implications of the signifier ‘rural’ in the Australian research literature to argue that while educational policy-makers must attempt to think differently about the 'problem of the rural’, the field itself also needs to more fully develop the capacity to do this.
Using 17th century medication for modern diabetes management: Doctors’ perceptions of self-medication practices – A qualitative study
Authors: Puvvada Rahul Krishna , Tang Clarice Y. , Thomas Jency , Kay Mitch , Higgs Peter , Jois Markandeya , Madhan Ramesh , Gupta Sabrina 
Published: November 2022

Abstract
Purpose
This study was conducted to explore doctors’ perceptions and understanding of the self-medication practices of people living with type 2 diabetes.

Methods
A qualitative research design incorporating 20 semi-structured, face-to-face interviews were conducted with doctors treating people with type 2 diabetes in Mysuru, India, between July 2019 and January 2020. All the interviews were conducted in doctors’ clinics, audio-recorded and thematically analyzed.

Results
Three themes were identified from these interviews- i) Doctors’ beliefs towards their patients’ use of traditional medicine and environmental factors influencing prescription practices, ii) Doctors reported little faith in traditional medicines, iii) Limited strategies implemented by doctors to overcome barriers to self-medications. Doctors reported greater belief in western medications over traditional medications and expressed concern that their patients favored traditional medications over western. Multiple factors such as social media, accessibility of healthcare facilities and pill burden influenced adherence to western medications. Also, lack of knowledge about traditional medications and trust in western medications available under government schemes have influenced prescription practices among doctors. It appears that doctors implemented strategies such as educating patients on the detrimental effects of self-medication and insisting on patients to take only western medications to achieve desired blood glucose levels when managing self-medication practices among people with diabetes.

Conclusion
These results suggest that doctors have limited strategies to implement to prevent self-medication practices among people with diabetes. Increasing knowledge amongst doctors about JAS medication effectiveness and thereby garnering greater trust in generic medications. In addition, efforts should be made to identify the best ways to integrate traditional and western medicine into patient-centered care delivery.