bluuebunny/crossref_metadata_2025_split huggingface dataset:
The complexity of kidney disease and diagnosing it – cystatin C, selective glomerular hypofiltration syndromes and proteome regulation
Authors: Malmgren Linnea , Öberg Carl , den Bakker Emil , Leion Felicia , Siódmiak Joanna , Åkesson Anna , Lindström Veronica , Herou Erik , Dardashti Alain , Xhakollari Liana , Grubb Gabriel , Strevens Helena , Abrahamson Magnus , Helmersson‐Karlqvist Johanna , Magnusson Martin , Björk Jonas , Nyman Ulf , Ärnlöv Johan , Ridefelt Peter , Åkerfeldt Torbjörn , Hansson Magnus , Sjöström Anna , Mårtensson Johan , Itoh Yoshihisa , Grubb David , Tenstad Olav , Hansson Lars‐Olov , Olafsson Isleifur , Campos Araceli Jarquin , Risch Martin , Risch Lorenz , Larsson Anders , Nordin Gunnar , Pottel Hans , Christensson Anders , Bjursten Henrik , Bökenkamp Arend , Grubb Anders 
Published: November 2022

AbstractEstimation of kidney function is often part of daily clinical practice, mostly done by using the endogenous glomerular filtration rate (GFR)‐markers creatinine or cystatin C. A recommendation to use both markers in parallel in 2010 has resulted in new knowledge concerning the pathophysiology of kidney disorders by the identification of a new set of kidney disorders, selective glomerular hypofiltration syndromes. These syndromes, connected to strong increases in mortality and morbidity, are characterized by a selective reduction in the glomerular filtration of 5–30 kDa molecules, such as cystatin C, compared to the filtration of small molecules <1 kDa dominating the glomerular filtrate, for example water, urea and creatinine. At least two types of such disorders, shrunken or elongated pore syndrome, are possible according to the pore model for glomerular filtration. Selective glomerular hypofiltration syndromes are prevalent in investigated populations, and patients with these syndromes often display normal measured GFR or creatinine‐based GFR‐estimates. The syndromes are characterized by proteomic changes promoting the development of atherosclerosis, indicating antibodies and specific receptor‐blocking substances as possible new treatment modalities. Presently, the KDIGO guidelines for diagnosing kidney disorders do not recommend cystatin C as a general marker of kidney function and will therefore not allow the identification of a considerable number of patients with selective glomerular hypofiltration syndromes. Furthermore, as cystatin C is uninfluenced by muscle mass, diet or variations in tubular secretion and cystatin C‐based GFR‐estimation equations do not require controversial race or sex terms, it is obvious that cystatin C should be a part of future KDIGO guidelines.
Personality maturation through sense of mastery? Longitudinal evidence from two education‐to‐work transition studies
Authors: Reitz Anne K. , den Boer Liselotte , van Scheppingen Manon A. , Diwan Ketaki 
Published: November 2022

AbstractObjectiveWhy personality changes in young adulthood remains a critical theoretical and empirical question. We studied personality change during the education‐to‐work transition, including mean‐level personality change and its specific timing, the degree of individual variability in change, and the link between sense of mastery and personality change.MethodsWe used two intensive longitudinal studies. Study 1 included 5 waves of data across 2 years during the university‐to‐work transition (N = 309; mean‐aged 25). Study 2 included 3 waves of data across 8 months during an internship‐heavy teacher education program (N = 317; mean‐aged 22). We measured personality traits and work‐related mastery with questionnaires and personality states and general mastery with the experience sampling method.ResultsFirst, we found no evidence for mean‐level personality maturation but decreases in trait Conscientiousness. Second, young adults differed significantly in personality trait and state change. Third, young adults with higher levels of work‐related sense of mastery showed more positive changes in trait Conscientiousness. Decreases in general sense of mastery predicted later decreases in state Emotional Stability and vice versa. Change in general sense of mastery correlated with personality state change.ConclusionsSense of mastery seems to be part of a dynamic short‐term process underlying personality change in young adulthood.
Tool use by the orange wrasse Pseudolabrus luculentus and doubleheader Coris bulbifrons
Authors: Pryor Kimberley Jane 
Published: November 2022

AbstractThe present study investigated whether temperate wrasses in a geographical location in the southern hemisphere break open crab prey on anvils. Here, tool‐use behaviour is reported in two temperate wrasses, the orange wrasse Pseudolabrus luculentus and the doubleheader Coris bulbifrons, at Lord Howe Island, Australia. In addition to the previous observations of this behaviour, these findings suggest that tool use is common and may be ubiquitous, in medium‐sized carnivorous wrasses that are undergoing an ontogenetic shift from soft‐bodied to hard‐shelled prey.
Carbon assimilation in upper subtidal macroalgae is determined by an inverse correlation between Rubisco carboxylation efficiency and CO2 concentrating mechanism effectiveness
Authors: Capó‐Bauçà Sebastià , Galmés Jeroni , Aguiló‐Nicolau Pere , Ramis‐Pozuelo Sonia , Iñiguez Concepción 
Published: November 2022

Summary

Seaweeds have a wide ecophysiological and phylogenetic diversity with species expressing different Rubisco forms that frequently coexist with biophysical CO2 concentrating mechanisms (CCMs), an adaptation that overcomes the low CO2 availability and gas diffusion in seawater.

Here, we assess the possible coevolution between the Rubisco catalysis and the type and effectiveness of CCMs present in six upper subtidal macroalgal species belonging to three phylogenetic groups of seaweeds.

A wide diversity in the Rubisco kinetic traits was found across the analyzed species, although the specificity factor was the only parameter explained by the expressed Rubisco form. Differences in the catalytic trade‐offs were found between Rubisco forms, indicating that ID Rubiscos could be better adapted to the intracellular O2 : CO2 ratio found in marine organisms during steady‐state photosynthesis. The biophysical components of the CCMs also differed among macroalgal species, resulting in different effectiveness to concentrate CO2 around Rubisco active sites. Interestingly, an inverse relationship was found between the effectiveness of CCMs and the in vitro Rubisco carboxylation efficiency, which possibly led to a similar carboxylation potential across the analyzed macroalgal species.

Our results demonstrate a coevolution between Rubisco kinetics and CCMs across phylogenetically distant marine macroalgal species sharing the same environment.
Revisiting the oil droplet sign in keratoconus: Utility for early keratoconus diagnosis and screening
Authors: Gideon Abou Said Arige , Piñero David P. , Shneor Einat 
Published: November 2022

AbstractPurposeAn annular dark shadow (ADS) reflex has been observed while performing direct ophthalmoscopy on subjects with keratoconus. This study describes a method that may serve as a diagnostic technique for early keratoconus and may be used as a quantitative measure of severity.MethodsHealthy keratoconic subjects and keratoconus suspects underwent corneal tomography and a full ocular examination. Keratoconus severity was graded based on Belin ABCD criteria. An iPhone camera was connected to a direct ophthalmoscope to take a picture of the eye. The height of the ASD was measured using the AutoCAD software. Differences between subject groups were evaluated by chi‐squared and Mann–Whitney tests. Spearman correlation compared ocular parameters and the height of the ADS. A multiple stepwise linear regression was used to predict the height of the ADS based on clinical parameters.ResultsFifty‐eight subjects participated in this study: 37 healthy controls (37 eyes) and 21 keratoconics or keratoconus suspects (37 eyes). The ADS was present in all keratoconic and keratoconus‐suspect eyes but in none of the controls. The height of the ADS was significantly correlated with keratoconus severity. Front corneal surface root mean square of higher order aberrations, sphere and anterior radius of curvature from the front apex curve are significant predictors of the height of the ADS.Conclusions and relevanceThe ADS may be a useful method to diagnose keratoconus and keratoconus‐suspect cases and serve as a grading and follow‐up method for tracking disease severity.
Blueberry muffin baby secondary to ganglioneuroblastoma
Authors: Montero‐Vilchez Trinidad , Navarro‐Pelayo Isabel , Sanchez‐Díaz Manuel , Ortega‐Acosta Maria‐Jose , Arias‐Santiago Salvador , Tercedor‐Sanchez Jesus 
Published: November 2022

AbstractWe report the case of a neonate presenting with the clinical features of blueberry muffin syndrome caused by ganglioneuroblastoma, a rare variant of neuroblastoma. This syndrome may be the only visible manifestation of a neonatal tumor and highlights the importance of early recognition and initiation of therapy to reduce mortality.
On the Periodicity of the Rational Dynamical System Corresponding to the Vannimenus–Ising Model
Authors: Akin Hasan 
Published: November 2022

Abstract
The universal behaviors of a rational dynamical system associated with the Vannimenus–Ising model having two coupling constants on a Cayley tree of order three are studied. Cobweb diagrams and related map iterates for some relevant parameters are investigated. The local stability of fixed points is discussed and illustrated through cobweb diagrams. We deal with quantitative universality, such as orbit diagrams and Lyapunov exponents for a class of rational maps. We show that our model is periodic using orbit diagrams and relevant Lyapunov exponents.
Artificial Gorilla Troops Optimizer for Frequency Regulation of Wind Contributed Microgrid System
Authors: Ramesh Maloth , Yadav Anil Kumar , Pathak Pawan Kumar 
Published: November 2022

Abstract
The high penetration of renewable energy resources (RESs) based microgrids (MGs) into the modern power system brings severe system frequency fluctuations due to RESs uncertain nature. In such cases, supplying an MG model with an effective load frequency control (LFC) plays a crucial part in regaining the stability of the electrical network. In this work, a wind turbine generator (WTG) and diesel generator (DEG) are efficiently planned as autonomous diesel wind energy-based microgrid (DWMG). A wind-contributed dynamic model, speed regulator, and proportional-integral-derivative (PID) frequency controller are designed to make the WTG system aware of power fluctuations. Additionally, an integral type sliding mode control (I-SMC) is designed to generate the supplementary control action for the frequency regulation against the load and source uncertainties. A recently invented artificial gorilla troops optimizer (GTO) is utilized to obtain the controller parameters. The results reveal the proposed method's benefits, such as least frequency deviations, shorter settling time, and minimum integral errors over state-of-the-art methodologies.
Construction of Friction Model of the Third Body Layer and Its Effects on the Dynamic Characteristics in Brake System
Authors: Zhang Yuhang , Wei Daogao , Wu Bofu , Jiang Ping 
Published: November 2022

Abstract
The noise of disk brake pair has always been a difficult problem for enterprises and researchers. Many factors induce the noise of disk brake pair, among which the influence of the third body particle flow generated by the external gravel or its own abrasive debris has not been paid much attention. Three-body contact has different friction properties and requires a new friction model to describe it. This paper presents a friction model of disk brake pair on the basis of the predecessors. The new model further considers the influence of the third body on the nonlinear behavior of the brake system on the basis of the previous model of the brake pair. Through numerical simulation, it is concluded that the geometry size of the third body has great influence on the stability interval of the braking system. Finally, the influence of the third body particles on the motion stability of the braking system under different particle size ranges is studied. It is found that larger particle size can improve the motion stability of the system.
On the Use of Half-Implicit Numerical Integration in Multibody Dynamics
Authors: Fang Luning , Kissel Alexandra , Zhang Ruochun , Negrut Dan 
Published: November 2022

Abstract
This work highlights the use of half-implicit numerical integration in the context of the index three differential algebraic equations (DAEs) of multibody dynamics. Although half-implicit numerical integration is well established for ordinary differential equations problems, to the best of our knowledge, no formal discussion covers its use in the context of index three DAEs of multibody dynamics. We wish to address this since when compared to fully implicit methods, half-implicit integration has two attractive features: (i) the solution method does not require the computation of the Jacobian associated with the constraint, friction, contact, or user-defined applied forces; and (ii) the solution is simpler to implement. Moreover, for nonstiff problems, half-implicit numerical integration yields a faster solution. Herein, we outline the numerical method and demonstrate it in conjunction with three mechanisms. We report on convergence order behavior and solution speed. The Python software developed to generate the results reported is available as open in a public repository for reproducibility studies.
Design of a Flexible Transducer Array and Characterisation of Piezoelectric Sensors for Curvature Compensation
Authors: Boerkamp Christiaan , Costa Tiago L. , Jovanova Jovana 
Published: November 2022

Abstract
Flexible ultrasound has emerged as the basis for wearable devices in healthcare. In this work, a flexible 1D phased transducer array has been proposed. This transducer array includes piezoelectric sensors underneath the transducer array, which detect its local curvature at different locations, corresponding to the positions of each piezoelectric sensor. Using FEA a simulation study was created, resulting in a deformed transducer array in which the number of curves and the number of sensors are varied. The piezoelectric sensors detect the local curvature resulting in a displacement map along the array. The sensing error of these sensors is calculated by taking the difference between the detected curvature from the sensors and the actual curvature the PCB was subjected to during the simulations. The results of these simulations show that, an increase of sensors results in a noticeable decrease in sensing error up to 9 sensors. Increasing the number of sensors after that point decreases the sensing error to a negligible value. The curvature information gathered from the piezoelectric sensors was then used to allow for the generation of focused ultrasound beams. To enable this, ultrasound beamforming algorithms were augmented to include curvature correction. These simulations showed that, despite a slight decrease in beam pressure of a curved transducer array compared to an uncurved array, the sensors can effectively detect and compensate for curvature in ultrasound transducer arrays.
Effects of a mindfulness-based and acceptance-based group programme
followed by physical activity for patients with fibromyalgia: a randomised
controlled trial
Authors: Haugmark Trond , Hagen Kåre Birger , Provan Sella Aarrestad , Smedslund Geir , Zangi Heidi A 
Published: November 2022

Introduction
Non-pharmacological approaches are recommended as first-line
treatment for patients with fibromyalgia. This randomised controlled
trial investigated the effects of a multicomponent rehabilitation
programme for patients with recently diagnosed fibromyalgia in primary
and secondary healthcare.

Methods
Patients with widespread pain ≥3 months were referred to
rheumatologists for diagnostic clarification and assessment of study
eligibility. Inclusion criteria were age 20–50 years, engaged in work or
studies at present or during the past 2 years, and fibromyalgia
diagnosed according to the American College of Rheumatology 2010
criteria. All eligible patients participated in a short patient
education programme before inclusion and randomisation. The
multicomponent programme, a 10-session mindfulness-based and
acceptance-based group programme followed by 12 weeks of physical
activity counselling was evaluated in comparison with treatment as
usual, that is, no treatment or any other treatment of their choice. The
primary outcome was the Patient Global Impression of Change (PGIC).
Secondary outcomes were self-reported pain, fatigue, sleep quality,
psychological distress, physical activity, health-related quality of
life and work ability at 12-month follow-up.

Results
In total, 170 patients were randomised, 1:1, intervention:control.
Overall, the multicomponent rehabilitation programme was not more
effective than treatment as usual; 13% in the intervention group and 8%
in the control group reported clinically relevant improvement in PGIC
(p=0.28). No statistically significant between-group differences were
found in any disease-related secondary outcomes. There were significant
between-group differences in patient’s tendency to be mindful (p=0.016)
and perceived benefits of exercise (p=0.033) in favour of the
intervention group.

Conclusions
A multicomponent rehabilitation programme combining patient
education with a mindfulness-based and acceptance-based group programme
followed by physical activity counselling was not more effective than
patient education and treatment as usual for patients with recently
diagnosed fibromyalgia at 12-month follow-up.

Trial registration number
BMC Registry (NCT96836577).
A systematic review of strategies adopted to scale up COVID-19 testing in low-, middle- and high-income countries
Authors: Muttamba Winters , O'Hare Bernadette Ann-Marie , Saxena Vibhor , Bbuye Mudarshiru , Tyagi Parul , Ramsay Andrew , Kirenga Bruce , Sabiiti Wilber 
Published: November 2022

ObjectiveWe undertook a systematic review of strategies adopted to scale up COVID-19 testing in countries across income levels to identify successful approaches and facilitate learning.MethodsScholarly articles in English from PubMed, Google scholar and Google search engine describing strategies used to increase COVID-19 testing in countries were reviewed. Deductive analysis to allocate relevant text from the reviewed publications/reports to the a priori themes was done.Main resultsThe review covered 32 countries, including 11 high-income, 2 upper-middle-income, 13 lower-middle-income and 6 low-income countries. Most low- and middle-income countries (LMICs) increased the number of laboratories available for testing and deployed sample collection and shipment to the available laboratories. The high-income countries (HICs) that is, South Korea, Germany, Singapore and USA developed molecular diagnostics with accompanying regulatory and legislative framework adjustments to ensure the rapid development and use of the tests. HICs like South Korea leveraged existing manufacturing systems to develop tests, while the LMICs leveraged existing national disease control programmes (HIV, tuberculosis, malaria) to increase testing. Continent-wide, African Centres for Disease Control and Prevention-led collaborations increased testing across most African countries through building capacity by providing testing kits and training.ConclusionStrategies taken appear to reflect the existing systems or economies of scale that a particular country could leverage. LMICs, for example, drew on the infectious disease control programmes already in place to harness expertise and laboratory capacity for COVID-19 testing. There however might have been strategies adopted by other countries but were never published and thus did not appear anywhere in the searched databases.
Quality of working life of medical doctors and associated risk factors: a cross-sectional survey in public hospitals in China
Authors: Tang Changmin , Guan Cuiling , Liu Chaojie 
Published: November 2022

ObjectivesTo assess the quality of working life (QWL) of medical doctors and associated risk factors.Setting and participantsA cross-sectional questionnaire survey of 2915 medical doctors from 48 hospitals was conducted in China.MethodsThe QWL-7–32 scale was adopted to assess seven domains of QWL: physical health, mental health, job and career satisfaction, work passion and initiative, professional pride, professional competence, and balance between work and family.Primary and secondary outcome measuresData were analysed using SPSS V.19.0. Analysis of variance tests and multivariate linear regression analyses were performed to identify the sociodemographic characteristics and job factors associated with overall QWL and its seven subdomain scores.ResultsOn average, the respondents reported an overall QWL score of 92.51 (SD=17.74) of a possible 160. Over 35% of respondents reported more than 60 hours of weekly working time; 59.9% experienced night sleep deprivation frequently; 16.6% encountered workplace violence frequently. The multivariate regression models revealed that the eastern region (β≤−2.887 for non-eastern regions, p<0.001), shorter working hours (β≤−2.638 for over 40 hours a week, p<0.01), less frequent night sleep deprivation (β≤−5.366 for sometimes or frequent, p<0.001), higher income (β≥2.795 for lower income, p<0.001) and less frequent encounters of workplace violence (β≤−9.267 for sometimes or frequent, p<0.001) were significant predictors of higher QWL. Night sleep deprivation and workplace violence were common predictors (p<0.05) for all seven domains of QWL.ConclusionThe low QWL of medical doctors working in public hospitals in China is evident, which is associated with high workloads, low rewards and workplace violence. There are also significant regional differences in the QWL of medical doctors, with the eastern developed region featuring better QWL. Public hospitals in China are facing serious challenges in occupational health and safety, which needs to be addressed through a systems approach.