bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sleep And Positive Emotions In Adolescents With Anorexia Nervosa In Relation To The Covid-19 Pandemic
Authors: Rossi Lucia , Silva Catarina Da , Charvin Isabelle , Fonseca David Da , Bat-Pitault Flora 
Published: January 2022

Abstract
Purpose: The recent COVID-19 pandemic, and its consequent lockdown measures raised concerns about people’s mental health. Identified vulnerable groups may be especially at risk. This study investigated the impact of this unprecedent situation on sleeping patterns and emotionality in adolescents with anorexia nervosa (AN).Methods: Variations in sleeping patterns and emotionality of 101 adolescents with AN, assessed during the pandemic (Covid-19 Group), and the year before (No-Covid-19 Group) were analyzed. We further investigated these variations over time: before the lockdown, 9 months later and after the lockdown.Results: Adolescents in the Covid-19 Group had significantly higher rates of sleep alterations and lower rates of positive emotions, compared to the No-Covid-19 Group. A higher insomnia severity index score and a tendency to lengthen sleep latency time were also associated with the pandemic period. Considering three different groups of patients over time, the kinetics of the impact of the changes shows that the worsening of values is not strictly limited to the acute lockdown phase but is increasing over time. Conclusions: These sleep and emotionality features could have participated to increase severity and incidence of AN in adolescents during the Covid-19 pandemic. As such, these features could represent therapeutic targets to optimize the care of adolescents with AN, particularly urgent to improve considering the kinetic of the deterioration. Tools such as those provided by cognitive behavioral therapy for insomnia (CBTi) and by the positive psychology seem appropriate to guide clinicians in this context. Level of evidence: Level V, descriptive study (evaluation data retrospectively studied).
A New Method for Detecting Sleep Apnea
Authors: Xin Xiong , yaru zhang , Sanli Yi , Chunwu Wang , Ruixiang Liu , Jianfeng He 
Published: January 2022

Abstract
Sleep apnea is a sleep disorder that can induce hypertension, coronary heart disease, stroke and other diseases, so the detection of sleep apnea is clinically important for the prevention of these diseases. In order to improve the detection performance and verify which physiological signals are better for sleep apnea detection, this paper uses multi-channel signal superposition and channel summation to improve the content of valid information in the original signal. Thirty features are analyzed by Relief feature selection algorithm. Finally, 15 features were used to build a classification model and support vector machine (SVM) was used for classification. The experimental results showed that the highest accuracy of 96.24% was achieved when electrocardiogram (X2) and electroencephalogram (C3-A2) channels were used for channel summation.
Mitochondrial Proteomics and Transcriptional Analysis of Cytoplasmic Male Sterility in Sugar Beet using iTRAQ and qRT–PCR
Authors: Liu Tianjiao , Cheng Dayou , Han Xue , Cui Jie , Dai Cuihong , Li Junliang , Liang Naiguo 
Published: January 2022

Abstract
Sugar beet (Beta vulgaris L.) is an important raw material for the sugar industry, and its output is second only to sugar cane. Cytoplasmic male sterility (CMS) is a phenomenon of pollen abortion that has important implications in sugar beet hybrid breeding. Male plant sterility is usually considered to be associated with mitochondrial dysfunction. Although mitochondrial genes associated with male sterility have been well explored, the different mitochondrial proteomics of CMS in sugar beet are still poorly understood. In this study, differentially expressed mitochondrial proteomic analysis was performed on the flower buds of the male sterile line (DY5-CMS), its maintainer line (DY5-O) and a fertility restorer line (CL6), using an isobaric tag for relative and absolute quantitation (iTRAQ) technology. A total of 2260 proteins were identified by mass spectrometry, of which 538 were differentially expressed proteins. Most of them were involved in protein metabolism, carbohydrate and energy metabolism, and binding. More specifically, some cysteine and methionine metabolism proteins (A0A0J8BGE0, A0A0J8CZM6, A0A0J8D7W0 and A0A0J8BCR7) may play important roles during the formation of CMS. This study provided an in–depth understanding of the CMS molecular mechanism at the protein level in sugar beet.
Marein prevented LPS-induced osteoclastogenesis by regulating the NF-κB pathway in vitro
Authors: Li Yuling , Zhang Jing , Yan Caiping , Chen Qian , Xiang Chao , Zhang Qingyan , Wang Xingkuan , jiang ke 
Published: January 2022

Abstract
Gram-negative bacterial infection causes many bone diseases such as osteolysis, osteomyelitis and septic arthritis. Lipopolysaccharide (LPS), a bacteria product, played an important role in this process. Drugs that inhibited LPS-induced osteoclastogenesis were urgently needed for the prevention of bone destruction in infective bone diseases. Marein, a major bioactive compound of Coreopsis.tinctoria, which possesses anti-oxidative, anti-inflammatory, anti-hypertensive, anti-hyperlipidemic and anti-diabetic effects. In this study, the effect of marein on RAW264.7 cells was measured by CCK-8 assay; TRAP staining was used to determine osteoclastogenesis; the levels of osteoclast-related genes and NF-κB-related proteins were analyzed by WB; the levels of pro-inflammatory cytokines were quantified by ELISA. Our results showed that marein inhibited LPS-induced osteoclast formation from osteoclast precursor RAW264.7 cells. The effect of marein was related to its inhibitory function on expressions of pro-inflammatory cytokines and osteoclast-related genes including RANK, TRAF6, MMP-9, CK and CAⅡ. Besides, marein treatment could inhibit LPS-induced activation of NF-κB signaling pathway in RAW264.7 cells. Meanwhile, inhibition of NF-κB signaling pathway decreased the formation of osteoclasts and expression of pro-inflammatory cytokines which were LPS-induced. Collectively, marein could prevent LPS-induced osteoclast formation in vitro by regulating NF-κB signaling pathway. These findings provided evidence that marein might be beneficial as a valuable choice for the prevention and treatment of bacteria-induced bone destruction disease, and gave new insights for understanding its possible mechanism.
An anomalous atmospheric river linked to the late June 2021 western North America heatwave
Authors: Mo Ruping , Lin Hai , Vitart Frédéric 
Published: January 2022

Abstract
Atmospheric rivers (ARs) are long and narrow bands of enhanced water vapour flux concentrated in the lower troposphere. Many studies have documented the important role of cold-season ARs in producing heavy precipitation and triggering extreme flooding in many parts of the world. However, relatively little research has been conducted on the warm-season ARs and their impacts on extreme heatwave development. Here we show an anomalous warm-season AR moving across the North Pacific and its interaction with the western North American heatwave in late June 2021. We call it an “oriental express’’ to highlight its capability to transport tropical moisture to the west coast of North America from sources in Southeast Asia. Its landfall over the Alaska Panhandle lasted for more than two days and resulted in significant spillover of moisture into western Canada. We provide evidence that the injected water vapour was trapped under the heat dome and may have formed a positive feedback mechanism to regulate the heatwave development in western North America.
Response in Growth Performance, Physico-chemical Properties, and Fatty acid Composition of Broiler Meat to Different Levels of Mucuna Pruriens Seed Meal
Authors: Mthana Makiwa Simeon , Gajana Christian Sabelo , Moyo Bethwell , Hugo Arno , Makhamba Nasiphi , Thabethe Fortune 
Published: January 2022

Abstract
The study was conducted to determine the response in growth performance, physicochemical properties and fatty acid composition of broiler meat fed incremental levels of M. pruriens seed meal. A total of 112 Cobb 500, seven days old, unsexed broiler chicks with body weight of 150 ± 5.47 g/bird (mean ±SD) were used. Chicks were allotted to pens in a completely randomized design hence assigned to four experimental diets containing 0, 10, 15, and 20% of MPSM, respectively. Each diet was offered ad libitum with clean water to 28 broilers in each treatment. There was a linear decrease in average daily feed intake (ADFI), average daily gain (ADG) and final body weight (FBW) with incremental levels of MPSM (P < 0.05). Feed conversion ratio (FCR) increased linearly with increasing MPSM levels while Final Body Wight (FBW) decreased linearly with increasing levels of MPSM (P < 0.05). Meat pH24 and colour parameters showed no relationship with increasing levels of MPSM (P > 0.05). Thawing loss, carcass weight and cooking loss showed a linear increase with increasing levels of MPSM (P < 0.05). However, shear force showed a linear decrease with increasing levels of MPSM (P > 0.05). Muscle fat, fat free dry matter (FFDM) and moisture, mono-unsaturated fatty acids and margaric acid showed no relationship with increasing levels of MPSM (P > 0.05), however, a linear decrease (P < 0.05) on myristic acid and palmitic acid with incremental levels of MPSM was observed. Arachidic acid, and α-Linolenic acid increased linearly with inclusion level of MPSM (P < 0.05). Other poly-unsaturated fatty acids, fatty acid ratios and health lipid indices indicators showed no relationship with increasing levels of MPSM (P > 0.05). Increasing inclusion levels of MPSM impairs growth performance of broilers and may also improve broiler quality and fatty acid some fatty acids.
Effect of Physical Therapy on Bone Remodelling in Preterm Infants. A Multicenter Randomized Controlled Clinical Trial
Authors: Torró-Ferrero Galaad , Fernández-Rego Francisco Javier , Jiménez-Liria Rosario , Agüera-Arenas Juan Jose , Piñero-Peñalver Jessica , Sánchez-Joya María del Mar , Fernández-Berenguer María Jesús , Rodríguez-Pérez Mónica , Gomez-Conesa Antonia 
Published: January 2022

Abstract
Background: Preterm infants have a low level of bone mineralization compared to those born at term, since 80% of calcium incorporation occurs at the end of pregnancy. The purpose of the present study was to investigate the effect of reflex locomotion therapy on bone modeling and growth in preterm infants and to compare its effect with those of other Physiotherapy modalities.Methods: A multicentre randomized controlled clinical trial was conducted (02/2016 – 07/2020). 106 preterm infants born at the Virgen de la Arrixaca University Clinical Hospital, the General University Hospital of Elche and the Torrecárdenas Hospital in Almería, between 29 and 34 weeks with hemodynamic stability, complete enteral nutrition and without any metabolic, congenital, genetic, neurological or respiratory disorders were evaluated for inclusion. Infants were randomly assigned to three groups: one group received reflex locomotion therapy (EGrlt); another group received passive mobilizations with gentle joint compression (EGpmc); and the control group received massage (CG). All treatments were carried out in the neonatal units lasting one month. The main outcome measure was bone formation and resorption measured with bone biomarkers. A mixed ANOVA was used to compare the results of bone biomarkers, and anthropometric measurements. Results: Infants were randomized to EGrlt (n = 38), EGpmc (n = 32), and CG (n = 36). All groups were similar in terms of gender (p = 0.891 female 47.2%), gestational age (M = 30.753, SD = 1.878, p = 0.39) and birth weight (M = 1413.45, SD = 347.36, p = 0.157). At the end of the study, significant differences were found between the groups in their interaction in bone formation, measured with osteocalcin [F (2,35) = 4.92, p = 0.013, ηp2 = 0.043], in benefit of the EGrlt. Conclusions: Reflex locomotion therapy has been effective in improving bone formation, more so than other Physiotherapy modalities. Therefore, reflex locomotion therapy could be considered one of the most effective physiotherapeutic modalities for the prevention and treatment of osteopenia of prematurity Trial registrstion: Trial retrospectively registered at ClinicalTrials.gov. First posted on 22/04/2020. Registration number: NCT04356807. URL: https://clinicaltrials.gov/ct2/show/NCT04356807?cond=Physical+Therapy+to+Prevent+Osteopenia+in+Preterm+Infants&draw=2&rank=1
Uptake of Screening Mammogram in West-central Illinois During COVID-19 Pandemic: Lessons Learned
Authors: Agboola John Owoade , Ayosanmi Oluwasola Stephen , Bezold Maureen P. , Mogbojuri Oluwatobi 
Published: January 2022

Abstract
Objectives. The study aims to reveal the trend of mammogram uptake in seventeen rural counties in Illinois to understand how the COVID-19 pandemic is influencing breast cancer screening in the area.Methods. Aggregated data on mammography screening for west central Illinois was provided by the Illinois Hospital Association. Data for 2018 and 2019 was used to determine the typical monthly and annual screenings for the two years before the onset of COVID-19. Then, the two years' data was compared to the 2020 data. The monthly mean values for the aggregated 2018 and 2019 data were generated as the base "year" to compare with the monthly value for 2020. Paired T-Test analysis was used to find if there were any statistically significant differences the years and between the base year and 2020.Results. January 2020 revealed an uptick to 2,921, which is more than the uptake for January 2018 (2700) and January 2019 (2488), and 13% greater than the mean value of 2,594 for the previous two years. This was followed by a gradual decrease in uptake in February 2020 by 4% compared to previous years at a mean of 2518 and a further decline in March (44%), with a drastic fall (98%) by April 2020 at 56 screening mammograms in all 17 counties. The lowest uptake in any three months occurred from March through May 2020. Compared to previous years, increase in uptake was noted across the region in 2020 June (8%) and July (4%) after the pandemic restrictions were relaxed. Overall, the total uptake in 2020 was 15% less than the average annual uptake for 2018-2019 with a deficit of 5,537. There was no statistically significant difference in mammogram uptake across the three years.Conclusion. The findings reveal that there was a significant reduction in uptake during the pandemic restriction period. However, increased uptake during the rest of the year effectively mitigated this reduction to such an extent that there was no statistically significant downturn compared to each of the previous two years. A rising trend in total annual uptake noted in preceding years could have continued without the COVID-19 event.
Quadruple Term Gestation of Quadri-Chorionic Quadri-Amniotic Pregnancy After Artificial Insemination: A Case Report
Authors: Caballero-Reyes Mauricio , Medina-Rivera Diana , Alas-Pineda César , Mejía-Raudales Beatriz , Gaitán-Zambrano Kristhel , Rubi Tesla Valle 
Published: January 2022

Abstract
Background: To solve infertility, modern science has promoted assisted reproduction techniques such as in vitro fertilization, ovulation induction, and artificial insemination. Quadruple-type multiple pregnancies occur in 1 of every 500,000 pregnancies, and it is estimated that 90% occur due to assisted reproductive techniques, which often lead to numerous complications. Case presentation: Here we present a case of a 33-year-old woman, who desired pregnancy, but had a history of primary infertility diagnosed by hysterosalpingography, and endometriosis, which was treated by fulguration and medical management. Concomitantly, the patient was anovulatory. To fulfill her wish, she underwent homologous artificial insemination, after treatment, she successfully conceived quadri-chorionic quadri-amniotic infants, who were born at 37.2 weeks, without perinatal or maternal complications.Conclusion: This paper presented the parameters of prenatal care, appropriate management approach, and successful resolution without maternal-fetal complications despite the inherent risks of this type of pregnancy.
Mechanically axially chiral catenanes and noncanonical mechanically axially chiral rotaxanes
Authors: Goldup Stephen , Maynard John , Gallagher Peter , Lozano David , Butler Patrick 
Published: January 2022

Abstract
The term chiral was introduced by Lord Kelvin over a century ago to describe objects that are distinct from their own mirror image. Chirality is relevant in many scientific areas, but particularly chemistry because different mirror image forms of a molecule famously have different biological properties. Chirality typically arises in molecules due to a rigidly chiral arrangement of covalently bonded atoms. Less generally appreciated is that molecular chirality can arise when molecules are threaded through one another to create a mechanical bond. For example, when two molecular rings with chemically distinct faces are joined like links in a chain the resulting structure is chiral even when the rings themselves are not. We re-examined the symmetry properties of such mechanically axially chiral catenanes and in doing so identified a straightforward route to these molecules from simple building blocks. This also led to the discovery of a previously overlooked mechanical stereogenic unit that can arise when such a ring encircles a dumbbell-shaped axle to generate a rotaxane. These insights allowed us to produce the first highly enantioenriched axially chiral catenane and the same approach gave access to a molecule containing the newly identified noncanonical axially chiral rotaxane motif. With methods to access these structures in hand, the process of exploring their properties and applications can now begin.
Deep Eutectic Solvents For Efficient Processing of Renewable Resources Into Sustainable Biofuels and High Value-Added Carbon-Based Fine Chemicals: Recent Developments, Challenges, and Future Perspectives
Authors: Lin Yuan-Chung (Oliver) , Amesho Kassian T.T. , Mohan S. Venkata 
Published: January 2022

Abstract
Green chemistry techniques for the exploitation of renewable resources have emerged as beneficial techniques for producing sustainable biofuels and high value-added carbon-based fine chemicals with the potential to decrease the impact of anthropogenic activities on the environment. Despite various green chemistry technologies for processing renewable resources into different valuable products, there are still several major issues concerning the pretreatment processes and techniques, such as high cost and high-energy consumption. Thankfully, deep eutectic solvents (DESs), a potentially attractive “green solvent” biodegradable substitute to environmentally harmful organic solvents, have been progressively exploited for renewable resources processing. Therefore, the central focus of this review is to present recent developments and challenges of DESs as processing green solvents for renewable resources. We believe this comprehensive review will provide new insights towards developing state-of-the-art sustainable and new green technologies for the efficient processing of renewable resources for sustainable biofuels and value-added carbon-based fine chemicals.
GLAM: An adaptive graph learning method for automated molecular interactions and properties predictions
Authors: Li Yuquan , Hsieh Chang-Yu , Lu Ruiqiang , Gong Xiaoqing , Wang Xiaorui , li Pengyong , Liu Shuo , Tian Yanan , Jiang Dejun , Yan Jiaxian , Bai Qifeng , Liu Huanxiang , Zhang Shengyu , Yao Xiaojun 
Published: January 2022

Abstract
Improving drug discovery efficiency is a core and long-standing challenge in drug discovery. For this purpose, many graph learning methods have been developed to search potential drug candidates with fast speed and low cost. In fact, the pursuit of high prediction performance on a limited number of datasets has crystallized them, making them lose advantage in repurposing to new data generated in drug discovery. Here we propose a flexible method that can adapt to any dataset and make accurate predictions. The proposed method employs an adaptive pipeline to learn from a dataset and output a predictor. Without any manual intervention, the method achieves far better prediction performance on all tested datasets than traditional methods, which are based on hand-designed neural architectures and other fixed items. In addition, we found that the proposed method is more robust than traditional methods and can provide meaningful interpretability. Given the above, the proposed method can serve as a reliable method to predict molecular interactions and properties with high adaptability, performance, robustness and interpretability. This work would take a solid step forward to the purpose of aiding researchers to design better drugs with high efficiency.
Point-of-Care Urine Gram Stain for Managing Febrile Urinary Tract Infection in Adults
Authors: Taniguchi Tomohiro , Tsuha Sanefumi , Shiiki Soichi , Narita Masashi 
Published: January 2022

Abstract
Background

Febrile urinary tract infections (fUTIs), which include pyelonephritis, prostatitis, and urosepsis, are the most common cause of sepsis. However, the treatment has become more complex because of the world-wide increase in antimicrobial resistance (AMR). The objective of this study was to clarify whether point-of-care Gram stain (PCGS) of urine contributed to fUTI diagnosis and treatment in adults.
Methods

This hospital-based observational study was undertaken between January 2013 and March 2015 in Okinawa, Japan. All enrolled patients were adults who had been admitted to the Division of Infectious Diseases with suspected fUTI. The usefulness of PCGS results were compared for urinalysis (U/A) and urine cultures (U/Cs). The targeted therapy type and its effectiveness based on PCGS were analyzed, and each was investigated in two groups: the uncomplicated pyelonephritis group and the complicated pyelonephritis/prostatitis group.
Results

Two hundred sixty-six patients were enrolled. The results of PCGS were closely correlated with those of U/A for pyuria and bacteriuria, and moderately correlated with the results of U/C for bacterial types. In the uncomplicated group, narrow-spectrum antimicrobials such as cefotiam were initially selected in 97.9% (47/48) of patients, and their effectiveness was 97.9% (47/48). In the complicated group, the effectiveness was 84.2% (186/221) (p=0.009) despite frequent AMRs (14.7%; 32/218) and low use of broad-spectrum antimicrobials such as carbapenems (7.7%; 17/221).
Conclusion

Urine PCGS led to a more precise fUTI diagnosis and prompted clinicians to select narrower-spectrum antibiotics with high effectiveness.