bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effective coverage of diabetes and hypertension: an analysis of Thailand’s national insurance database 2016–2019
Authors: Rajatanavin Nattadhanai , Witthayapipopsakul Woranan , Vongmongkol Vuthiphan , Saengruang Nithiwat , Wanwong Yaowaluk , Marshall Aniqa Islam , Patcharanarumol Walaiporn , Tangcharoensathien Viroj 
Published: December 2022

ObjectivesThis study assesses effective coverage of diabetes and hypertension in Thailand during 2016–2019.DesignMixed method, analysis of National health insurance database 2016–2019 and in-depth interviews.SettingBeneficiaries of Universal Coverage Scheme residing outside Bangkok.ParticipantsQuantitative analysis was performed by acquiring individual patient data of diabetes and hypertension cases in the Universal Coverage Scheme residing outside bangkok in 2016-2019. Qualitative analysis was conducted by in-depth interview of 85 multi-stakeholder key informants to identify challenges.OutcomesEstimate three indicators: detected need (diagnosed/total estimated cases), crude coverage (received health services/total estimated cases) and effective coverage (controlled/total estimated cases) were compared. Controlled diabetes was defined as haemoglobin A1C (HbA1C) below 7% and controlled hypertension as blood pressure below 140/90 mm Hg.ResultsEstimated cases were 3.1–3.2 million for diabetes and 8.7–9.2 million for hypertension. For diabetes, all indicators have shown slow improvement between 2016 and 2019 (67.4%, 69.9%, 71.9% and 74.7% for detected need; 38.7%, 43.1%, 45.1% and 49.8% for crude coverage and 8.1%, 10.5%, 11.8% and 11.7% for effective coverage). For hypertension, the performance was poorer for detection (48.9%, 50.3%, 51.8% and 53.3%) and crude coverage (22.3%, 24.7%, 26.5% and 29.2%) but was better for effective coverage (11.3%, 13.2%, 15.1% and 15.7%) than diabetes. Results were better for the women and older age groups in both diseases. Complex interplays between supply and demand side were a key challenge. Database challenges also hamper regular assessment of effective coverage. Sensitivity analysis when using at least three annual visits shows slight improvement of effective coverage.ConclusionEffective coverage was low for both diseases, though improving in 2016–2019, especially among men and ัyounger populations. The increasing rate of effective coverage was significantly smaller than crude coverage. Health information systems limitation is a major barrier to comprehensive measurement. To maximise effective coverage, long-term actions should address primary prevention of non-communicable disease risk factors, while short-term actions focus on improving Chronic Care Model.
SARS-CoV-2 antibody responses post-vaccination in UK healthcare workers with pre-existing medical conditions: a cohort study
Authors: Ward Victoria , Wei Jia , Gordon William , Barnes Eleanor , Dunachie Susie , Jeffery Katie , Eyre David , O’Donnell Anne-Marie 
Published: December 2022

ObjectivesTo examine antibody responses after the second vaccination in healthcare workers (HCWs) with underlying health conditions.DesignCohort study.SettingOxford University Hospitals in the United Kingdom.ParticipantsHealthcare workers who had SARS-CoV-2 serological data available and received two SARS-CoV- 2 vaccinations.Primary outcomePeak SARS-CoV-2 anti-spike IgG responses after the second vaccination and associations with underlying health conditions and the estimated risk of severe COVID-19 using an occupational health risk assessment tool.MethodsWe used univariable and multivariable linear regression models to investigate associations between antibody levels and demographics (age, sex, ethnicity), healthcare role, body mass index, underlying health conditions, vaccination status, prior infection and the Association of Local Authority Medical Advisors COVID-age risk score.Results1635 HCWs had anti-spike IgG measurements 14–84 days after second vaccination and data on any underlying health conditions. Only five HCWs (0.3%), all on immunosuppressive treatment, (including four organ transplant recipients), did not seroconvert after second vaccination. Antibody levels were independently lower with older age, diabetes, immunosuppression, respiratory disorders other than asthma and markedly so in organ transplant recipients. Levels were independently lower in ChAdOx1 versus BNT162b2 recipients and higher following previous infection. HCWs with ‘very high’ COVID-age risk scores had lower median antibody levels than those with ‘low’, ‘medium’ or ‘high’ risk scores; 4379 AU/mL, compared with 12 337 AU/mL, 9430 AU/mL and 10 524 AU/mL, respectively.ConclusionsTwo vaccine doses are effective in generating antibody responses among HCWs, including those with a high occupational risk. However, HCWs with underlying health conditions, especially diabetes, immunosuppression and organ transplant, had lower antibody levels, and vaccine response monitoring may be needed.
Improving cancer care for underserved populations in an academic and community practice setting: protocol for a community health worker pilot navigation programme
Authors: Suen Jonathan J , Parrillo Elaina , Hassoon Ahmed , Peairs Kimberly , Stanford Olivia , Wenzel Jennifer , Zabora James Robert , Dobs Adrian S 
Published: December 2022

IntroductionDelaying cancer treatment following diagnosis impacts health outcomes, including increasing patient distress and odds of mortality. Interventions to promote timely healthcare engagement may decrease patient-reported stress and improve quality of life. Community health workers (CHWs) represent an enabling resource for reducing delays in attending initial oncology treatment visits. As part of an ongoing programme evaluation coordinated by the Merck Foundation, we will implement a pilot navigation programme comprising CHW-conducted needs assessments for supporting patients and their caregivers. We aim to investigate (1) the programme’s influence on patients’ healthcare utilisation within the period between their first diagnosis and initial treatment visit and (2) the logistic feasibility and acceptability of programme implementation.Methods and analysisWe will employ a hybrid implementation design to introduce the CHW navigation programme at the Johns Hopkins Sidney Kimmel Comprehensive Cancer Center. CHW team members will use a consecutive sampling approach. Participants will complete the Problem-Checklist, Chronic Illness Distress Scale and the Satisfaction with Life Domains instruments. CHWs will provide tailored guidance by sharing information available on the Johns Hopkins Electronic Resource databases. The investigators will evaluate patients’ time to initial oncology treatment and healthcare utilisation by reviewing electronic medical records at 3 and 6 months postintervention. Bivariate analyses will be completed to evaluate the relationships between receiving the programme and all outcome measures.Ethics and disseminationThis study’s protocol was approved by the Johns Hopkins School of Medicine’s institutional review board (IRB00160610). Informed consent will be obtained by phone by the CHW navigator. Dissemination planning is ongoing through regular meetings between members of the investigator team and public members of two community advisory groups. Study plans include collaborating with other experts from the Johns Hopkins Institute for Clinical and Translational Research and the Johns Hopkins Center for Health Equity for ideating dissemination strategies.
Effects of feeding graded levels of camelina expeller meal up to 10% of dietary dry matter on production and milk fatty acid profiles in dairy cows
Authors: Mutsvangwa Timothy , Abeysekara Saman , Thompson Sean 
Published: December 2022

Eight Holstein cows were used in a replicated 4 × 4 Latin square design study to determine the effects of partially replacing canola meal (CM) with 5%, 7.5%, and 10% camelina expeller meal (CEM) on production and milk fatty acid profiles. Replacing CM with CEM did not affect feed intake and milk yield, but milk contents of fat and protein decreased linearly. Feeding increasing amounts of CEM linearly increased milk contents of C18:2n6, C18:3n3, cis-9, trans-11 CLA, trans-10, cis-12 CLA, and total CLA. CEM can be fed up to 10% of dietary DM without negatively affecting production and can increase milk contents of omega-3 fatty acids.
COVID-19 pandemic: the impact on Canada’s intensive care units
Authors: Gibney R.T. Noel , Blackman Cynthia , Gauthier Melanie , Fan Eddy , Fowler Robert , Johnston Curtis , Jeremy Katulka R. , Marcushamer Samuel , Menon Kusum , Miller Tracey , Paunovic Bojan , Tanguay Teddie 
Published: December 2022

The COVID-19 pandemic has exposed the precarious demand-capacity balance in Canadian hospitals, including critical care where there is an urgent need for trained health care professionals to dramatically increase ICU capacity. The impact of the pandemic on ICUs varied significantly across the country with provinces that implemented public health measures later and relaxed them sooner being impacted more severely. Pediatric ICUs routinely admitted adult patients. Non-ICU areas were converted to ICUs and staff were redeployed from other essential service areas. Faced with a lack of critical care capacity, triage plans for ICU admission were developed and nearly implemented in some provinces. Twenty eight percent of patients in Canadian ICUs who required mechanical ventilation died. Surviving patients have required prolonged ICU admission, hospitalization and extensive ongoing rehabilitation. Family members of patients were not permitted to visit, resulting in additional psychological stresses to patients, families, and healthcare teams. ICU professionals also experienced extreme psychological stresses from caring for such large numbers of critically ill patients, often in sub-standard conditions. This resulted in large numbers of health workers leaving their professions. This pandemic is not yet over, and it is likely that new pandemics will follow. A review and recommendations for the future are provided.
Classical n-body system in volume variables II: Four-body case
Authors: Escobar-Ruiz A. M. , Turbiner Alexander V. 
Published: December 2022

It is evident that the positions of four bodies in [Formula: see text]-dimensional space can be identified with vertices of a tetrahedron. Square of volume of the tetrahedron, weighted sum of squared areas of four facets and weighted sum of squared edges are called the volume variables. A family of translation-invariant potentials which depend on volume variables alone had been considered as well as solutions of the Newton equations which solely depend on volume variables. For the case of zero angular momentum [Formula: see text], the corresponding Hamiltonian, which describes these solutions, is derived. Three examples are studied in detail: (I) the (super)integrable four-body closed chain of harmonic oscillators for [Formula: see text] (the harmonic molecule); (II) a generic, two volume variable-dependent potential whose trajectories possess a constant moment of inertia ([Formula: see text]) and (III) the four-body anharmonic oscillator for [Formula: see text]. This work is the second of the sequel: the first one [A. M. Escobar-Ruiz, R. Linares, A. V. Turbiner and W. Miller Jr., Int. J. Mod. Phys. A 36, 2150140 (2021)] was dedicated to study the three-body classical problem in volume variables.
Chapter 11. North Sea Basin Jurassic lithostratigraphy
Authors: Copestake Philip , Partington Mark A. 
Published: December 2022

Abstract
The most important North Sea Jurassic–lowermost Cretaceous lithostratigraphic units, as developed in the UK, Norway and Danish sectors, are summarized in this chapter (55 units from the UK, 25 from Norway and 10 from Denmark). Some significant issues remain with the use and application of lithostratigraphic terminology in the Jurassic of the North Sea Basin. In particular, there are inconsistencies in unit definition and nomenclature changes across country sector boundaries that obscure the recognition of regional stratigraphic patterns that exist across the region. To aid clarity and to overcome some issues of definition, some revisions are made to the existing lithostratigraphic schemes. Several informal lithostratigraphic units are described, a number of unit definitions are revised and various formerly informal units are formalized (Buzzard Sandstone Member, Ettrick Sandstone Member and Galley Sandstone Member). It is recommended that use of the Heno Formation in offshore Denmark is discontinued. In addition, four new lithostratigraphic member terms are introduced (Home Sandstone Member, North Ettrick Sandstone Member, Gyda Sandstone Member and Tambar Sandstone Member). All described units are placed into a sequence stratigraphic context. All significant lithostratigraphic boundaries conform with key sequence stratigraphic surfaces.
Chapter 12. Well sequence stratigraphy interpretation methodology
Authors: Copestake Philip 
Published: December 2022

Abstract
This chapter describes the methodology employed to recognize depositional sequences in well data, involving the integration of wireline logs, biostratigraphy, lithostratigraphy (and lithological interpretations), seismic and sedimentology (particularly facies analysis), with an emphasis on a pragmatic approach to sequence recognition in North Sea Jurassic–lowermost Cretaceous well successions. Wireline log profiles characterizing individual depositional sequences or parts of sequences are illustrated by reference to key North Sea well sections.
Changing palaeobiogeography during the Ordovician Period
Authors: Servais Thomas , Harper David A. T. , Kröger Björn , Scotese Christopher , Stigall Alycia L. , Zhen Yong-Yi 
Published: December 2022

Abstract
Owing to the increasing availability of data for many fossil groups and a generally accepted palaeogeographical configuration, palaeontologists have been able to develop progressively more robust palaeobiogeographical scenarios for the spatial distributions of Ordovician marine faunas. However, most research in Early Paleozoic palaeobiogeography centres on data derived from extensively studied localities in North America and Europe. Thus, clear patterns are emerging of regional biogeography for these areas. However, the fragmentary nature of data from other regions hinders the development of a detailed understanding of palaeogeographical schemes of many clades at the global level. Provincial patterns are now available for several fossil groups, but the global coverage remains generally fragmentary. Palaeobiogeographical investigations were traditionally focused on better understanding of palaeogeographical scenarios and often employed quantitative analyses of faunal similarity. More recently palaeobiogeographical analyses have expanded to investigate questions such as the location and pace of speciation and macroevolution together with macroecological change. For example, studies on the evolution of speciation levels in the frame of the taxonomic radiation of the Great Ordovician Biodiversification are now available. Future investigations, including modelling, will provide more integrative, global patterns of provincialism, including the location of Ordovician biodiversity hotspots and the recognition of latitudinal diversity gradients.
The Impact of Kidney Function on the Slow-Flow/No-Reflow Phenomenon in Patients Treated with Primary Percutaneous Coronary Intervention: Registry Analysis
Authors: Savic Lidija , Mrdovic Igor , Asanin Milika , Stankovic Sanja , Lasica Ratko , Krljanac Gordana , Rajic Dubravka , Simic Damjan 
Published: December 2022

Objective. The objective of this study is to analyze the impact of declining kidney function on the occurrence of the slow-flow/no-reflow phenomenon in patients with ST-elevation myocardial infarction (STEMI) treated with primary PCI (pPCI), as well as the analysis of the prognostic impact of the slow-flow/no-reflow phenomenon on short- and long-term mortality in these patients. Methods. We analyzed 3,115 consecutive patients. A value of the glomerular filtration rate (eGFR) at the time of admission of eGFR <90 ml/min/m2 was considered a low baseline eGFR. The follow-up period was 8 years. Results. The slow-flow/no-reflow phenomenon through the IRA was registered in 146 (4.7%) patients. Estimated GFR of <90 ml/min/m2 was an independent predictor for the occurrence of the slow-flow/no-reflow phenomenon (OR 2.91, 95% CI 1.25–3.95,

p

< 0.001), and the risk for the occurrence of the slow-flow/no-reflow phenomenon increased with the decline of the kidney function: eGFR 60–89 ml/min/m2: OR 1.94 (95% CI 1.22–3.07,

p

= 0.005), eGFR 45–59 ml/min/m2: OR 2.55 (95% CI 1.55–4.94,

p

< 0.001), eGFR 30–44 ml/min/m2: OR 2.77 (95% CI 1.43–5.25,

p

< 0.001), eGFR 15–29 ml/min/m2: OR 5.84 (95% CI 2.84–8.01,

p

< 0.001). The slow-flow/no-reflow phenomenon was a strong independent predictor of short- and long-term all-cause mortality: 30-day mortality (HR 2.62, 95% CI 1.78–3.57,

p

< 0.001) and 8-year mortality (HR 2.09, 95% CI 1.49–2.09,

p

< 0.001). Conclusion. Reduced baseline kidney function was an independent predictor for the occurrence of the slow-flow/no-reflow phenomenon, and its prognostic impact started with the mildest decrease in eGFR (below 90 ml/min/m2) and increased with its further decline. The slow-flow/no-reflow phenomenon was a strong independent predictor of mortality in the short- and long-term follow-up of the analyzed patients.
CHIP Happens: Clonal Hematopoiesis of Indeterminate Potential and Its Relationship to Solid Tumors
Authors: Reed Sarah C. , Croessmann Sarah , Park Ben Ho 
Published: December 2022

AbstractClonal hematopoiesis of indeterminate potential (CHIP) is characterized by the expansion of hematopoietic cells harboring leukemia-associated somatic mutations in otherwise healthy people and occurs in at least 10% of adults over 70. It is well established that people with CHIP have increased rates of hematologic malignancy, increased risk of cardiovascular disease, and worse all-cause mortality compared with those without CHIP. Despite recent advancements in understanding CHIP as it relates to these known outcomes, much remains to be learned about the development and role of CHIP in other disease states. Emerging research has identified high rates of CHIP in patients with solid tumors, driven in part by oncologic therapy, and revealed associations between CHIP and differential outcomes in both solid tumors and other diseases. Recent studies have demonstrated that CHIP can contribute to dysregulated inflammatory signaling in multiple contexts, underscoring the importance of interrogating how CHIP might alter tumor immunology. Here, we review the role of CHIP mutations in clonal expansion of hematopoietic cells, explore the relationship between CHIP and solid tumors, and discuss the potential roles of CHIP in inflammation and solid tumor biology.
A Pilot Study of Intralesional Injection of Triamcinolone Acetonide for Desmoid Tumors: Two-Year Outcomes
Authors: Wilke Benjamin K. , Garner Hillary W. , Bestic Joseph M. , Chase Lori A. , Heckman Michael G. , Schoch Jennifer J. , Attia Steven 
Published: December 2022

Abstract

Purpose:
The purpose of this pilot study was to examine the clinical efficacy and safety of serial triamcinolone injections for the treatment of desmoid tumors.

Patients and Methods:
Nine patients were enrolled into this prospective study and underwent three serial ultrasound-guided triamcinolone injections (120 mg) at 6-week intervals. MRI was compared at baseline and every 6 months, out to 24 months. Safety and tolerability were assessed by clinical evaluation and questionnaires, including the 12-item short form survey (SF-12), visual analog scale (VAS), and desmoid patient-reported outcome (PRO) tool.

Results:
At 24 months, 8 (88.9%) patients demonstrated a reduction in the volume of their tumor while 1 (11.1%) enlarged. Median tumor volume change was −26.9% (−81.1% to 34.6%; P = 0.055) All 9 tumors remained stable based on World Health Organization criteria, whereas 2 (22.2%) demonstrated partial response based on RECIST. There was a significant decrease in the tumor:muscle postcontrast mean signal intensity ratio at 6 months (P = 0.008) and 24 months (P = 0.004). There was a similar decrease in the tumor:muscle T2 mean signal intensity ratio at 24 months (P = 0.02). We found no difference in the SF-12 and VAS scores, but there were significant improvements in the desmoid PRO.

Conclusions:
Treatment of desmoid tumors with serial triamcinolone injections appears safe and well tolerated by patients, with a 22% partial response based on RECIST. Further research is needed to confirm our results and determine factors predictive of response.
Abstract IA005: Artificial intelligence for breast pathology: Challenges and opportunities (and more challenges!)
Authors: Drage Michael G. 
Published: December 2022

Abstract
This presentation will review some fundamental aspects of breast pathology, introduce PathAI’s approach to building algorithms for computer vision applications, and highlight some applications where AI has shown capacity to yield clinically-relevant insights from breast cancer specimens. I will also highlight some interesting challenges in breast pathology practice pertinent to intraductal proliferations, and how these challenges are beginning to be addressed in the field of AI.
Citation Format: Michael G. Drage. Artificial intelligence for breast pathology: Challenges and opportunities (and more challenges!) [abstract]. In: Proceedings of the AACR Special Conference on Rethinking DCIS: An Opportunity for Prevention?; 2022 Sep 8-11; Philadelphia, PA. Philadelphia (PA): AACR; Can Prev Res 2022;15(12 Suppl_1): Abstract nr IA005.