bluuebunny/crossref_metadata_2025_split huggingface dataset:
The RNA methylase FTO mediates circRNF220 demethylation, and circRNF220 binds to serine/arginine-rich splicing factor 1 to promote the progression of acute myeloid leukemia
Authors: He JinHua , Han ZePing , Luo WenFeng , Sen Jian , Xie FangMei , Pan Ting , Hong Qu , Guo ZhongHui , Li JianHao , Li YuGuang , Cheng HanWei 
Published: June 2022

Abstract
Background: The key circular RNAs (circRNAs) and the molecular mechanisms by which they regulate the progression of acute myeloid leukemia (AML) in adults are unclear.Methods: We used a circRNA microarray to analyze the differentially expressed circRNAs in peripheral blood mononuclear cells of newly diagnosed adult AML patients. Reverse transcription-PCR, fluorescence in situ hybridization, Sanger sequencing, and ribonuclease R tests were used to examine circRNF220 loop formation and stability and its potential value in AML diagnosis. Cell Counting Kit-8, flow cytometry, and subcutaneous tumor assays were used to detect the effects of circRNF220 on the proliferation and apoptosis of the HL-60 and THP-1 cell lines. RNA antisense purification, methylated RNA immunoprecipitation, and RNA pull-down assays were used to identify circRNF220-binding proteins and microRNAs.Results: CircRNF220 was located in the cytoplasm and was more stable than linear RNF220. The area under the curve value of circRNF220 for the diagnosis of AML was 0.8314. Silencing circRNF220 expression inhibited the growth and promoted the early apoptosis of HL-60 and THP-1 cells. CircRNF220 had no competitive endogenous relationship with microRNAs. The RNA methylase FTO regulated the demethylation and expression of circRNF220. The RNA-binding protein serine/arginine-rich splicing factor 1 (SRSF1) and circRNF220 co-localized in the cytoplasm, and circRNF220 promoted SRSF1 expression. Furthermore, silencing circRNA220 reduced the tumorigenicity of AML cells in vivo.Conclusions: CircRNF220 is a potential biomarker for the diagnosis of adult AML. FTO mediates circRNF220 demethylation. and circRNF220 binds to SRSF1 to promote the progression of AML.
Regional groundwater sustainability assessment through enhancing conveyance and application efficiencies of irrigation water
Authors: Kumar Manoj , Singh D. K. , Sarangi A. , Mani Indra , Khanna Manoj 
Published: June 2022

Abstract
Groundwater depletion is a big sustainability challenge of 21st century all around the world. Local water authorities are in urgent need of concrete and focused steps to ensure sustainable groundwater management policies as quickly and as effectively as possible to achieve the sustainable development goals. For sustainable and efficient utilization of groundwater resources a study was conducted in farmer’s field of Rasoolpur jatan village in Western U.P, India. This study presents a new approach to explore and evaluate the impact of various water management technologies on water table fluctuations in order to build up a sustainable groundwater use strategy. In this paper modeling was done to simulate the future groundwater table behaviour and give the alternate course of management options. Sugarcane crop covered the maximum part of study area and irrigation is being done through earthen open channel. When water is applied through earthen channel with 60% application efficiency (Ea), the water table would decline at 0.57 m/yr. The water table would decline at 0.39 m/yr, when application efficiency of unlined earthen channel increased to 65%. To avoid conveyance losses water is applied through pipe distribution network with 79% application efficiency, in this case water table would rise by 0.05 m/yr and when irrigation is done with drip system with Ea = 90%, water table would rise by 0.27 m/yr. The groundwater level for the year 2030 under four scenarios projected as 213.84, 217.20, 225.39 and 229.37 m respectively. Simulated results suggest that the sustainability of groundwater could be ensured in the study area by enhancing efficiency of irrigation water or shift from traditional irrigation methods to modern irrigation i.e. drip and sprinkler irrigation system or timely transformation like change the cropping pattern.
Blockchain-based Secure Data Transmission for Internet of Underwater Things
Authors: Razzaq Abdul 
Published: June 2022

Abstract
Internet of Things (IoTs) is an integrated network collection of heterogeneous objects which enable seamless integration between systems, humans, devices, and various other things, to support pervasive computing for smart systems. IoT-driven systems and sensors continuously ingest data resulting in an increased volume and velocity of information which can lead to critical concerns such as security of the data and scalability of the system. The Internet of Underwater Things (IoUTs) is a specific genre of IoTs in which data related to oceanic ecosystems is continuously sensed through underwater sensors. IoUT has emerged as an innovative paradigm to support smart oceans. However, there are several critical challenges which IoUT system designers must consider such as (i) scalability of the system to handle large volumes of oceanic data and (ii) security of data that is transmitted from IoT sensors deployed underwater. Blockchain as a newly emerged technology and an enabling platform allows decentralized and secure transmission of data among a wide group of untrustworthy parties. This research aims to exploit blockchain technology to secure IoUT data transmission by exploiting Interplanetary File System (IPFS) method. Additionally, this study also addresses the system's scalability in two aspects, (i) scalability, and (ii) security. We used a case study-based approach and performed experiments to evaluate the proposed solution's usability and efficiency in terms of query response (i.e., performance), and algorithmic execution (i.e., efficiency). The proposed solution unifies blockchain technologies to secure IoT-driven systems and provides guidelines to engineer and develop next-generation of robust and secure blockchain-aided distributed IoT systems.
Genomic analyses identify significant molecules and signaling pathways in ameloblastoma
Authors: Wang Mengshan , Wang Xueying , Chung Andrew 
Published: June 2022

Abstract
Ameloblastoma is a locally aggressive odontogenic neoplasm that occurs in the vicinity of the mandibular molars or ramus. However, the mechanisms of ameloblastoma are still unclear. Here, our objective is to identify the key genes and signaling pathways by analyzing the RNA-seq data. The GSE186489 was created by the Illumina HiSeq 2500 (Homo sapiens). The gene enrichments indicated that the Chemical carcinogenesis − reactive oxygen species and prion disease are the key related signaling pathways in the development of ameloblastoma. Moreover, we determined several interactive genes including KIF11, BUB1, CDCA8, CDC20, ASPM, TOP2A, CCNB1, AURKA, TTK, and NCAPG. Our study may shed insights on the mechanism of ameloblastoma.
WITHDRAWN: Autothermal process intensification of continuous flow reactors for fuel cell applications
Authors: Chen Junjie 
Published: June 2022

Abstract
Process Intensification has attracted considerable interest as a potential means of process improvement and to meet the increasing demand for sustainable production. Process Intensification aims to improve yields and selectivity by using novel reactions or running reactions at more extreme parameters. This study relates to autothermal process intensification of continuous flow reactors for fuel cell applications. Computational fluid dynamics simulations are conducted to better understand the autothermal process within the continuous flow reactor. The effects of wall heat conduction properties and channel dimensions on autothermal process intensification are investigated. The results indicate that autothermal process intensification can be achieved for the continuous flow reactor. Reaction heat flux profiles are greatly affected by the dimensions of the continuous flow reactor. The peak reaction heat flux increases with the channel dimensions while maintaining the flow rates. The thermal conductivity of the channel walls is fundamentally important. Thermally conductive ceramics and metals are well-suited. Wall materials with poor heat conduction properties degrade the reactor performance. Materials with high thermal conductivity are preferred for the channel walls. Design recommendations are made for autothermal process intensification of continuous flow reactors.
WITHDRAWN: Physical insights in experimental studies of transport phenomena in low-dimensional nanomaterials from the perspective of thermal conductivity
Authors: Chen Junjie 
Published: June 2022

Abstract
In physics, the study of transport phenomena concerns the exchange of mass, energy, charge, momentum and angular momentum between observed and studied systems. Mass, momentum, and heat transport all share a very similar mathematical framework, and the parallels between them are exploited in the study of transport phenomena to draw deep mathematical connections that often provide very useful tools in the analysis of one field that are directly derived from the others. The heat transport phenomena in low-dimensional nanomaterials were studied to understand the characteristics of nanoscale thermal conduction. The parallel thermal conductance technique was employed to determine the thermal conductivity. The importance of cross-sectional and area bulk density was determined experimentally. The results indicated that the low-dimensional nanomaterials are very efficient at conducting heat. The structure, purity, and alignment of the low-dimensional nanomaterials play a fundamentally important role in determining the characteristics of nanoscale thermal conduction. The low-dimensional nanomaterials generally have high thermal conductivity. The presence of non-carbonaceous impurities degrades the thermal performance due to the low degree of bundle contact. The thermal conductivity may present power law dependence with temperature. The specific thermal conductivity decreases with increasing bulk density. At room temperature, a maximum specific thermal conductivity is obtained but Umklapp scattering occurs. The specific thermal conductivity of the low-dimensional fiber nanomaterials is significantly higher than that of the low-dimensional film nanomaterials due to the increased degree of bundle alignment.
Teacher Perceptions of Culturally and Linguistically Diverse Newcomer Parents: Shifting the Paradigm from Deficit Perspectives to Asset-Based Approaches
Authors: Nikolovski Johnny 
Published: June 2022

Abstract
This study explores teacher perceptions of newcomer parents and investigates how a small sample of teachers are making the shift from deficit to asset-based approaches to working with newcomer parents. This research uses one-on-one semi-structured interviews with three Toronto District School Board high school teachers to examine their perceptions of newcomer families living in Toronto, Ontario. Critical race theory is used as the theoretical framework for this study to critically analyse teachers’ conceptualization of asset-based approaches. Research findings reveal specific strategies used by the participants in incorporating asset-based approaches to working with newcomer parents and their children. This study also provides critical reflection opportunities for teachers who wish to engage in asset-based work in and beyond their multicultural classroom.
MiR-455-3p inhibits hepatocellular carcinoma tumorigenesis, lymphangiogenesis and angiogenesis via regulating vascular endothelial growth factor C and vascular endothelial growth factor receptor-2
Authors: Bin Xiaoyun , Zhou Sufang 
Published: June 2022

Abstract
Background: MicroRNAs (miRNAs), which may function as either tumor suppressor genes or oncogenes, exert considerable regulatory influence on biological processes. Previous studies have shown that miR-455-3p is significantly downregulated in hepatocellular carcinoma (HCC); however, the specific role of miR-455-3p in HCC is unclear. Methods: We used qRT-PCR to detect the levels of miR-455-3p in HCC cells. We used colony formation assay, EdU assay, and CCK-8 assay to check the effect of miR-455-3p on the proliferation of HCC and HuH-7 cells. Further, transwell and scratch assays were employed to identify the role of miR-455-3p in invasion and migration in these cells. Western blot analysis, angiogenesis assay, dual-luciferase reporter gene assay, and bioinformatic analysis were also performed to investigate the underlying molecular mechanisms. Results: MiR-455-3p was down-regulated in the HCC cells. In vitro experiments showed that miR-455-3p overexpression inhibits HCC cell proliferation, migration, and invasion. Interestingly, vascular endothelial growth factor C (VEGFC) was identified as a downstream target of miR-455-3p. Additionally, overexpression of miR-455-3p in HCC cells and human umbilical vein endothelial cells (HUVECs) led to a decreased expression of VEGFC and the vascular endothelial growth factor receptor (VEGFR)-2. This subsequently led to a downregulation of the phosphatidylinositol 3-kinase (PI3K)-AKT signaling pathway. Furthermore, in vivo overexpression of miR-455-3p significantly suppressed the tumorigenicity of HuH-7 cells in nude mice and inhibited both angiogenesis and lymphangiogenesis in tumor xenografts. Conclusions: Our findings suggest that miR-455-3p plays a role in HCC tumorigenesis, at least in part by modulating angiogenesis and lymphangiogenesis by targeting VEGFC and simultaneously blocking the AKT signaling pathway.
REA: resource exergy analysis - Guidelines for evaluating and comparing energy systems
Authors: Jentsch Andrej 
Published: June 2022

Abstract
Evaluating energy systems using resource exergy analysis (REA) is key to ensure that climate targets are reached in time.The reason for this effect is wastefulness. Wastefulness, even in otherwise GHG-free energy systems, increases the amount of energy required to cover the total energy demand. If using GHG-free energy systems wastefulness leads to reduced availability of GHG-free energy for the rest of the energy system. Since the energy demand is largely independent of energy production, wastefulness increases overall fossil fuel use.REA allows to assess wastefulness comprehensively and thus obtain a key indicator in addition to GHG emissions, that is grounded in science, namely resource exergy consumption.This publication provides guidelines to the application of resource exergy analysis (REA) with a focus on energy systems evaluation.REA is a well-tested application of exergy analysis to the field of technology comparison that can replace the less comprehensive primary energy analysis and reduce the risk of suboptimal decisions.
Discrimination and sexual violence against women and girls in conflict-related settings. An approach to the colombian case from the concluding observations of the CEDAW Committee
Authors: Chaparro Piedrahita Laura 
Published: June 2022

The concluding observations issuance by the Committee on the Elimination of All Forms of Discrimination against Women is arguably the single most important activity of this human rights treaty body. It provides an opportunity to deliver a comprehensive overview of the status of human rights protection for women in a state party and the submission of forms of guidance that can stimulate systemic advancement.
Although the Committee recognizes and welcomes the efforts of Colombia in undertaking legislative reforms in the health, education, and service sectors to eradicate discriminatory gender stereotypes, access for women to justice, especially in cases of sexual and domestic violence, guarantees for participation in political and public life, and other actions for the fulfillment of their rights, there are still serious concerns about gross human rights violations taking place in the country; one the most complex issue is sexual violence in the context of the armed conflict as many non-state actors are still using these brutal practices to achieve military purposes and as spoils of war.
This paper aims to analyze the causes of conflict-related sexual violence, how they constitute a form of prejudice and the intersectionality of this phenomenon with other forms of discrimination against women. Finally, it introduces some recommendations on additional related issues that seem to have been omitted by the Committee, even though they constitute severe breaches of the obligations and duties of the government under international law.
Cuidado de Enfermagem à Idosa com Síndrome da Fragilidade fundamentado na Teoria do Conforto
Authors: Fonteles Lucena Sarah Lídia , Silva Farias Fernanda , Malaquias Cordeiro Lucélia , Reis Coutinho Daisy Teresinha , Da Silva Lucia De Fatima , De Freitas Maria Célia 
Published: June 2022

Objetivo: descrever resultados e intervenções/atividades de Enfermagem para a idosa com o Diagnóstico de Enfermagem Síndrome do Idoso Frágil, fundamentado na Teoria do Conforto. Método: Estudo de caso clínico, realizado com idosa com o Diagnóstico de Enfermagem síndrome do idoso frágil, residente de Instituição de Longa Permanência. Resultados: Os resultados, intervenções de enfermagem planejadas foram fundamentadas na Classificação dos Resultados de Enfermagem e Classificação das Intervenções de Enfermagem. Conclusão: Considera-se relevante a aplicabilidade da linguagem de enfermagem na prática clínica do enfermeiro com vista a firmar a identidade da profissão.Descritores: Enfermagem; Idoso; Fragilidade; Instituição de Longa Permanência para Idosos; Teoria de Enfermagem.NURSING CARE FOR ELDERLY WOMEN WITH FRAGILITY SYNDROME BASED ON COMFORT THEORY Objective: To describe Nursing results and interventions / activities for the elderly with the Nursing Diagnosis of the Frailty Elderly Syndrome, based on Comfort Theory. Methods: Clinical case study, carried out with an elderly woman with fragile elderly syndrome, resident of an Long Term Elderly Care Institution. Results: The nursing interventions were based on the classification of nursing outcomes and classification of nursing interventions. Conclusion: The applicability of the nursing language it’s considered relevant in the clinical practice and helps establish the identity of the nursing profession. Keywords: Nursing; Aged; Frailty; Homes for the aged; Nursing theory. CUIDADO DE ENFERMERÍA A MUJER ADULTA MAYOR CON SÍNDROME DE FRAGILIDAD BASADO EN LA TEORÍA DE LA COMODIDAD Objetivo: Describir los resultados de las intervenciones/actividades de Enfermería dirigidas a la anciana con diagnóstico de Enfermería síndrome del anciano frágil, una base en la teoría de la comodidad. Métodos: Estudio de caso clínico, realizado en anciana con diagnóstico de Enfermería síndrome del anciano fragil, residente de Instituciones de larga estancia para personas de edad. Resultados: Los resultados, las intervenciones / la actividad de enfermería planificada se basaron en la clasificación de los resultados de enfermería y la clasificación de las intervenciones de enfermería. Conclusión: Se considera relevante la aplicabilidad del lenguaje de enfermería en la práctica clínica de la enfermera con el fin de reafirmar la identidad de la profesión. Descriptores: Enfermería; Anciano; Fragilidad; Hogares para ancianos ; Teoría de enfermería
Mechanism of Action-Governed Design of Anthracycline Antibiotics: A "Turn-Off/ Turn-On" Approach
Authors: Priebe Waldemar 
Published: June 2022

We present a novel approach to the design of more effective anthracyclines based on structUre­ mechanism of action relationships rather than on classical structure-activity relationships . The core of this approach is first, the identification of structural elements critical for a particular mechanism of action and then, the use of chemical modifications to "tum off ," or reduce participation of, certain mechanism s while "turning on," i.e., maintaining or increasing participation of, the desired mechanism. Subse-quently , this approach will lead to a better understanding of the molecular interaction of anthracyclines with targets . To illustrate the potential of this approach for anthracycline s, we focus on chemical alterations that can tum · off P-glycoprotein-mediated efflux and in consequence allow circumvention of multidrug resistance without suppressing the drug's ability to inhibit topoisomerase II. We review the mechanistic effects of
deamination and decreased basicity, as well as their biological relevance. Particularly, we concentrate on	.
the effects of amino group removal from C-3' and replacement with a hydroxy group, a change that leads to increased activity against multidrug-resistant tumors in vitro and in vivo . Using this approach, we have selected and developed Annamycin, a new drug with clearly altered mechanisms of action that is currently undergoing phase I clinical evaluation.
Synthesis and Preliminary Biological Evaluation of New Phthalazinone
Derivatives with PARP-1 and Cholinesterase Inhibitory Activities
Authors: Min Zhenli , Lin Yu , Gao Chengzhi , Wang Zhuyong , Zhang Ruifeng , Chen Yajun 
Published: June 2022

Background:
Alzheimer's disease (AD) is the most common brain disorder and remains a major
health concern worldwide. Considering the highly complex mechanisms of AD, the search for agents
based on a multitarget-directed ligands (MTDLs) strategy to treat AD may be more promising than the
traditional “one drug-one target” strategy. Inhibition of Poly (ADP-ribose) polymerases-1 (PARP-1) has a
potentially therapeutical effect on AD. Therefore, it is worthy to investigate compounds that target both
PARP-1 and cholinesterase, which perhaps produces new agents against AD.

Objective:
To search for new agents with PARP-1 and cholinesterase inhibitory activities for the treatment
of AD.

Methods:
A series of 21 novel compounds incorporated the respective pharmacophores of two marketed
drugs, namely the 4-benzyl phthalazinone moiety of a PARP-1 inhibitor, Olaparib, and the Nbenzylpiperidine
moiety of an AChE inhibitor, Donepezil, into one molecule was synthesized. The inhibitory
activities of all the synthesized compounds against the enzymes PARP-1, acetylcholinesterase
(AChE) and butyrylcholinesterase (BChE) were evaluated. The binding modes of the most potent compound
inside the PARP-1 and the human BChE (hBChE) were investigated by molecular docking.

Results:
N-((1-(4-fluorobenzyl)piperidin-4-yl)methyl)-2-fluoro-5-((1, 2-dihydro-1-oxophthalazin-4-
yl)methyl)benzamide (30) exhibited the most potent inhibitory effect on PARP-1 enzyme
(IC50=8.18±2.81nM) and moderate BChE inhibitory activity (IC50=1.63±0.52μM), while its AChE inhibitory
activity (IC50=13.48±2.15μM) was weaker than Donepezil (IC50=0.04±0.01μM). Further molecular
docking studies revealed that four hydrogen bonds were formed between 30 and PARP-1, meanwhile, 30
interacted with the critical residues His438 and Trp82 of hBChE through hydrogen bonds and hydrophobic
interactions, which were necessary for hBChE inhibitory potency.

Conclusion:
A new compound with potent PARP-1 inhibitory activity and moderate BChE inhibitory
activity was obtained, which merited to be further investigated as an anti-AD drug. The studies gave a
clue to search for new agents based on PARP-1 and cholinesterase dual-inhibited activities to treat AD.