bluuebunny/crossref_metadata_2025_split huggingface dataset:
PERANCANGAN SISTEM INFORMASI PENDAFTARAN UMROH BERBASIS WEB PADA NURRAHMA TOUR & TRAVEL
Authors: Anwar Syaiful , Hilpiah Dida 
Published: June 2022

Nurrahma Tour & Travel perwakilan Bogor adalah biro jasa perjalanan umroh, dimana perusahaan ini dalam melayani pendaftaran paket umroh mengalami kesulitan dalam pengolaan data pesertanya. Masalah yang terjadi pada sistem saat ini, calon jamaah umroh masih melakukan pendaftaran secara manual seperti mengisi formulir, pencarian data jamaah masih dicari secara manual sehingga tidak efisien, dan pembuatan laporan daftar jamaah yang cukup lama karena harus mengumpulkan data secara keseluruhan. Maka salah satu solusi pemecahan masalah tersebut dengan membuat aplikasi pendaftaran umroh. Metode penelitian ini merupakan studi kasus perancangan aplikasi online menggunakan model waterfall yang terdiri dari lima tahapan pembahasannya disertai juga dengan LRS dan Navigasi. Tujuan dari penelitian ini ingin mengimplementasikan sistem pendaftaran umroh secara online kepada para calon jamaah untuk meningkatkan efektifitas bagi calon jamaah maupun perusahaan itu sendiri.. Dan hasil dari penelitian ini berupa rancangan aplikasi pendaftaran umroh yang dapat dijalankan secara online sehingga memudahkan dalam melakukan pendaftaran umroh dan pengelolaan datanya.
LEARNING INDEPENDENCE OF BIOLOGICAL EDUCATION STUDENTS IN CALCULUS COURSE ONLINE REVIEWED BY GENDER
Authors: Silitonga R. H. Yanti 
Published: June 2022

This research was conducted to determine the independence of student learning in calculus courses conducted online based on gender. This type of research is descriptive quantitative. The subjects in this study were 34 biology education students. There are 4 male students and 30 female students. Methods of data collection using a scale of learning independence. The results showed that there were significant differences in the learning independence of male and female students. Female students outperform male students for all indicators of independent learning. The percentage of the average score of male students 'learning independence was 59.37, while the percentage of the average score of female students' learning independence reached 66.54.

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Metagenomic Next-Generation Sequencing Versus Traditional Laboratory Methods for the Diagnosis and Treatment of Infection in Liver Transplantation
Authors: Huang Jun-Feng , Miao Qing , Cheng Jian-Wen , Huang Ao , Guo De-Zhen , Wang Ting , Yang Liu-Xiao , Zhu Du-Ming , Cao Ya , Huang Xiao-Wu , Fan Jia , Zhou Jian , Yang Xin-Rong 
Published: June 2022

BackgroundMetagenomic next-generation sequencing (mNGS) has emerged as an effective method for the noninvasive and precise detection of infectious pathogens. However, data are lacking on whether mNGS analyses could be used for the diagnosis and treatment of infection during the perioperative period in patients undergoing liver transplantation (LT).MethodsFrom February 2018 to October 2018, we conducted an exploratory study using mNGS and traditional laboratory methods (TMs), including culture, serologic assays, and nucleic acid testing, for pathogen detection in 42 pairs of cadaveric liver donors and their corresponding recipients. Method performance in determining the presence of perioperative infection and guiding subsequent clinical decisions was compared between mNGS and TMs.ResultsThe percentage of liver donors with mNGS-positive pathogen results (64.3%, 27/42) was significantly higher than that using TMs (28.6%, 12/42; P&lt;0.05). The percentage of co-infection detected by mNGS in liver donors was 23.8% (10/42) significantly higher than 0.0% (0/42) by TMs (P&lt;0.01). Forty-three pathogens were detected using mNGS, while only 12 pathogens were identified using TMs. The results of the mNGS analyses were consistent with results of the TM analyses in 91.7% (11/12) of donor samples at the species level, while mNGS could be used to detect pathogens in 66.7% (20/30) of donors deemed pathogen-negative using TMs. Identical pathogens were detected in 6 cases of donors and recipients by mNGS, among which 4 cases were finally confirmed as donor-derived infections (DDIs). For TMs, identical pathogens were detected in only 2 cases. Furthermore, 8 recipients developed early symptoms of infection (&lt;7 days) after LT; we adjusted the type of antibiotics and/or discontinued immunosuppressants according to the mNGS results. Of the 8 patients with infections, 7 recipients recovered, and 1 patient died of severe sepsis.ConclusionsOur preliminary results show that mNGS analyses can provide rapid and precise pathogen detection compared with TMs in a variety of clinical samples from patients undergoing LT. Combined with symptoms of clinical infection, mNGS showed superior advantages over TMs for the early identification and assistance in clinical decision-making for DDIs. mNGS results were critical for the management of perioperative infection in patients undergoing LT.
Case Report: Tachycardia, Hypoxemia and Shock in a Severely Burned Pediatric Patient
Authors: Shi Jianshe , Huang Chuheng , Zheng Jialong , Ai Yeqing , Liu Hiufang , Pan Zhiqiang , Chen Jiahai , Shang Runze , Zhang Xinya , Dong Shaoliang , Lin Rongkai , Huang Shurun , Huang Jianlong , Zhang Chenghua 
Published: June 2022

BackgroundSeverely burned children are at high risk of secondary intraabdominal hypertension and abdominal compartment syndrome (ACS). ACS is a life-threatening condition with high mortality and requires an effective, minimally invasive treatment to improve the prognosis when the condition is refractory to conventional therapy.Case presentationA 4.5-year-old girl was admitted to our hospital 30 h after a severe burn injury. Her symptoms of burn shock were relieved after fluid resuscitation. However, her bloating was aggravated, and ACS developed on Day 5, manifesting as tachycardia, hypoxemia, shock, and oliguria. Invasive mechanical ventilation, vasopressors, and percutaneous catheter drainage were applied in addition to medical treatments (such as gastrointestinal decompression, diuresis, sedation, and neuromuscular blockade). These treatments did not improve the patient's condition until she received continuous renal replacement therapy. Subsequently, her vital signs and laboratory data improved, which were accompanied by decreased intra-abdominal pressure, and she was discharged after nutrition support, antibiotic therapy, and skin grafting.ConclusionACS can occur in severely burned children, leading to rapid deterioration of cardiopulmonary function. Patients who fail to respond to conventional medical management should be considered for continuous renal replacement therapy.
On the Bleaching Degree of Multi-Grain Coarse Quartz OSL Signal of Near-Surface Aeolian Sediments Around the Tengger Desert: Empirical Investigation and Numerical Validation
Authors: Mo Hongwei , Peng Jun , Li Zhenguo , Song Yan , Feng Teng 
Published: June 2022

In this study, the degree of bleaching of multi-grain coarse quartz optically stimulated luminescence (OSL) signal of near-surface aeolian samples collected around the Tengger Desert is assessed. The single-aliquot regenerative dose (SAR) protocol and the standardized growth curve (SGC) method are applied to measure the equivalent dose (De) of these samples. The bleaching degree of the samples is assessed by investigating 1) the relationship between Ln/Tn and SAR De and 2) the SGC De distribution. Various degrees of heterogeneously-bleached multi-grain dose distributions synthetized with a numerical simulation method is further used to validate the bleaching performance of the samples. It demonstrates that the investigated samples are characterized by tight De distributions and the maximum De estimate is smaller than 1.1 Gy. The numerical simulation method which uses as input a large proportion of fully-bleached grains and a small baseline dose is able to reproduce multi-grain De distributions similar to the measured ones. We conclude that OSL signals of multi-grain coarse quartz extracted from most of the investigated aeolian samples are fully bleached before deposition.
Geochemical Constraints on the Hydrothermal Dolomitization of the Middle-Upper Cambrian Xixiangchi Formation in the Sichuan Basin, China
Authors: Liang Jintong , Liu Sibing , Li Luping , Dai Jie , Li Xiaotian , Mou Chuanlong 
Published: June 2022

The Middle-Upper Cambrian Xixiangchi carbonates in the Sichuan Basin have been pervasively dolomitized. In the presented work, petrographic investigation revealed three generations of the Xixiangchi dolomites, consisting of dolomicrite (D1, 5–20 μm) with a planar-s to non-planar texture, fabric destructive dolomite (D2, 50–150 μM) with a planar-s to planar-e texture, and saddle dolomite (D3, 300 μm to 4 mm) with a planar-s to planar-e texture. D1 and D2 dolomites are presented as matrix dolomites, whereas D3 dolomites are observed as fracture-filling dolomites. Compared with the matrix D1 and D2 dolomites, which are interpreted as products of dolomitization under near-surface or at shallow burial conditions, the depleted δ13C and δ18O values of D3 than D1 and D2 dolomites are probably caused by the temperature-controlled isotopic fractionation within an increasing fluid–rock interaction at burial. The enriched Mn, Sr, and Ba concentrations of D3 than D1 and D2 dolomites suggest a newly introduced type of diagenetic fluids, which is probably related to the upwelling of magmatic activities (Emeishan large igneous province). By contrast, the abnormally depleted Fe concentration in D3 dolomites is attributed to its preferential incorporation into other solid phases rather than its true concentration. The similar rare earth element (REE) partition patterns of D1 and D2 dolomites demonstrate similar dolomitization fluids related to seawater or marine-origin fluids. The hydrothermal-derived D3 dolomites exhibit a different REE partition pattern by contrast. The negative Eu anomalies of D3 dolomites may represent hydrothermal fluid cooling or an association with intermediate-felsic igneous rocks. The findings of the presented work would enhance our understanding on the hydrothermal dolomitization of the Middle-Upper Cambrian Xixiangchi Formation.
Gestational Diabetes Mellitus Among Asians – A Systematic Review From a Population Health Perspective
Authors: Li Ling-Jun , Huang Lihua , Tobias Deirdre K. , Zhang Cuilin 
Published: June 2022

ObjectiveSince Asians are particularly vulnerable to the risk of gestational diabetes mellitus (GDM), the lifecourse health implications of which are far beyond pregnancy, we aimed to summarize the literature to understand the research gaps on current GDM research among Asians.MethodsWe systematically searched the articles in PubMed, Web of Science, Embase, and Scopus by 30 June 2021 with keywords applied on three topics, namely “GDM prevalence in Asians”, “GDM and maternal health outcomes in Asians”, and “GDM and offspring health outcomes in Asians”.ResultsWe observed that Asian women (natives and immigrants) are at the highest risk of developing GDM and subsequent progression to type 2 diabetes among all populations. Children born to GDM-complicated pregnancies had a higher risk of macrosomia and congenital anomalies (i.e. heart, kidney and urinary tract) at birth and greater adiposity later in life.ConclusionThis review summarized various determinants underlying the conversion between GDM and long-term health outcomes in Asian women, and it might shed light on efforts to prevent GDM and improve the lifecourse health in Asians from a public health perspective.Systematic Review RegistrationProspero, CRD42021286075.
Favorable Genotypes of Type III Interferon Confer Risk of Dyslipidemia in the Population With Obesity
Authors: Xu Tiantian , Peng Bo , Liu Mengmeng , Liu Qingjing , Yang Junya , Qu Minli , Liu Na , Lin Lizhen , Wu Jing 
Published: June 2022

BackgroundStudies have indicated that the chronic state of inflammation caused by obesity leads to dyslipidemia. However, how the polymorphisms involved in these inflammatory pathways affect the lipid metabolism in people with obesity is poorly understood. We investigated the associations of inflammation-related gene polymorphisms with dyslipidemia in individuals with obesity living in China.MethodsThis case–control study in a population with obesity involved 194 individuals with dyslipidemia and 103 individuals without dyslipidemia. Anthropometric indices of obesity, fasting plasma glucose, blood pressure, blood lipids, and C-reactive protein were evaluated. The genes we tested were IL6 (interleukin 6), IL6R (interleukin 6 receptor), FOXP3 (forkhead box P3), TLR2 (toll-like receptor 2), TLR4 (toll-like receptor 4), IFNL3 (interferon lambda 3, formerly known as IL28B), and IFNL4 (interferon lambda 4, formerly known as IL29). Polymorphisms were genotyped using matrix-assisted laser desorption/ionization-time of flight mass spectrometry.ResultsThere were significant differences in the allelic and genotype frequencies of IFNL3 (IL28B) rs12971396, rs8099917, rs11882871, rs12979860, rs4803217 between non-dyslipidemia and dyslipidemia groups in people with obesity. These single nucleotide polymorphisms (SNPs) of IFNL3 were highly linked (D′ and r &gt; 0.90), so the result of one SNP could represent the result of other SNPs. For IFNL3 rs12971396, people with the homozygous genotype (the major group) carried a higher risk of dyslipidemia than people with the heterozygous genotype (P &lt; 0.001, OR = 4.46, 95%CI, 1.95–10.22).ConclusionsThe favorable genotypes of type III interferon, which have a beneficial role in anti-virus function, were associated with dyslipidemia in a Chinese population with obesity. Type III interferon could have a pathologic role and confer risk of dyslipidemia in people with obesity and chronic inflammation.
Numerical Analysis of the Condensing Steam Flow by Means of ANSYS Fluent and in-House Academic Codes With Respect to the Capacity for Thermodynamic Assessment
Authors: Shabani Sima , Majkut Mirosław , Dykas Sławomir , Wiśniewski Piotr , Smołka Krystian , Cai Xiaoshu , Zhang Guojie 
Published: June 2022

In this paper numerical analysis of the condensing steam flow in a converging-diverging nozzle is investigated. The ANSYS Fluent results are compared with the results of the in-house academic Computational fluid dynamics code with respect to the capacity for thermodynamic assessment. The “local” real gas equation of state is used as a mathematical complement of flow governing equations in the in-house code. In the Fluent code, the thermodynamic functions as well as the steam and water physical properties are calculated based on the IAPWS formulation with the use of the UDF. The condensation model with the Fuchs and Sutigin correction of the droplet growth equation and nucleation rate with the Kantrowitz correction is implemented in both CFD codes. The CFD results are compared with the obtained experimental data. The experiment was carried out using an in-house steam facility with a transonic steam tunnel. The investigated geometry is a converging-diverging nozzle as adopted under the International Wet Steam Experimental Project with the diverging section expansion rate of 3,000 s−1 and the total throat height of 40 mm.
A Data Driven Based Ultra Short PV Forecasting Method With Sky Images
Authors: Liang Liang , Bai Xiaoyang 
Published: June 2022

With increasing levels of renewable energy in power systems, the coordination of different types of dispatchable resources, such as coal-fired power plants, hydropower plants, energy storage systems, and electric vehicles, has become more important than before. To optimally dispatch these operating units, the quality of the forecasting results becomes increasingly important for the operation of power systems. In this study, an ultra-short forecasting method was proposed for photovoltaic (PV) systems. It provided a forecast of the power output for the following 5 min using sky images obtained photographically in real time. The brightness of the key area was an important factor in determining the output power of the PV system. The output power was calculated using several different features extracted from the sky images. The brightness and other key features were then processed by a bidirectional long short-term memory network. The accuracy of the proposed PV forecasting method improved the accuracy of the forecast for the total power system. A testbed system was established to capture sky images in real time and verify the effectiveness of the proposed method.
Effect of Aerobic Exercise on Lipid Metabolism in Rats With NAFLD
Authors: Zhou Tongxi , Niu Mengfan , Liu Ruichen , Li Li 
Published: June 2022

This work aimed to study the intervention effect of exercise on lipid metabolism in NAFLD rats, provide a more scientific experimental basis for exploring and improving the theoretical system of exercise intervention in NAFLD, and further provide a theoretical research basis for clinical treatment of NAFLD. Forty healthy male Sprague Dawley rats were randomly divided into a blank control group (BC,14) and a model group (MO, 26). After 6°weeks of modeling, the MO group was randomly divided into the model control group (MC, 12) and the aerobic exercise group (AE, 12). Platform running intervention in group E was conducted at a slope of 0°, a speed of 15 m/min, 1 h/time, once a day, six times a week, and a day of rest, for 8°weeks in total. After the intervention, the liver tissues of rats were taken for pathological sections, and serum was taken and analyzed for TC, TG, LDL-C, HDL-C, and FFA levels. Under the light microscope, the liver tissue structure of rats in the BC group was complete and clear, the structure of liver lobules was clear and normal, the volume of hepatocytes was uniform, the nucleus was in the middle, and the cytoplasm was red-stained, and no steatosis of hepatocytes was found. The liver of rats in the MC group showed diffuse fatty lesions, disordered structure of hepatic lobules, disordered arrangement of hepatic cords, different sizes of hepatocytes, loose cytoplasm, and diffuse lipid droplets of different sizes in the cytoplasm. The accumulation of liver lipid droplets in the AE group was improved compared with the MC group, the number of fat vacuoles in hepatocytes was significantly reduced, and the degree of liver lipid deposition was reduced. Compared with the BC group, the content of TC, TG, LDL-C, and FFA in the serum of the MC group increased significantly (p &lt; 0.01), and the content of HDL-C decreased significantly (p &lt; 0.01). Compared with the MC group, the content of TC, TG, LDL-C, and FFA in the serum of the AE group decreased significantly (p &lt; 0.01/p &lt; 0.05), and the content of HDL-C increased significantly (p &lt; 0.01). Therefore, moderate-intensity aerobic exercise has an intervention effect on lipid metabolism in NAFLD rats, which can be used as one of the means to treat NAFLD.
Identification of NAD+ Metabolism-Derived Gene Signatures in Ovarian Cancer Prognosis and Immunotherapy
Authors: Lin Liang , Chen Li , Xie Zuolian , Chen Jian , Li Ling , Lin An 
Published: June 2022

Background: Nicotinamide adenine dinucleotide (NAD+) has emerged as a critical regulator of cell signaling and survival pathways, affecting tumor initiation and progression. In this study it was investigated whether circulating NAD+ metabolism-related genes (NMRGs) could be used to predict immunotherapy response in ovarian cancer (OC) patients.Method: In this study, NMRGs were comprehensively examined in OC patients, three distinct NMRGs subtypes were identified through unsupervised clustering, and an NAD+-related prognostic model was generated based on LASSO Cox regression analysis and generated a risk score (RS). ROC curves and an independent validation cohort were used to assess the model’s accuracy. A GSEA enrichment analysis was performed to investigate possible functional pathways. Furthermore, the role of RS in the tumor microenvironment, immunotherapy, and chemotherapy was also investigated.Result: We found three different subgroups based on NMRGs expression patterns. Twelve genes were selected by LASSO regression to create a prognostic risk signature. High-RS was founded to be linked to a worse prognosis. In Ovarian Cancer Patients, RS is an independent prognostic marker. Immune infiltrating cells were considerably overexpressed in the low-RS group, as immune-related functional pathways were significantly enriched. Furthermore, immunotherapy prediction reveal that patients with low-RS are more sensitive to immunotherapy.Conclusion: For a patient with OC, NMRGs are promising biomarkers. Our prognostic signature has potential predictive value for OC prognosis and immunotherapy response. The results of this study may help improve our understanding of NMRG in OCs.
Clinical Characteristics, In Silico Analysis, and Intervention of Neonatal-Onset Inflammatory Bowel Disease With Combined Immunodeficiency Caused by Novel TTC7A Variants
Authors: Chen Yun-e , Chen Jingfang , Guo Wenxing , Zhang Yanhong , Li Jialing , Xie Hui , Shen Tong , Ge Yunsheng , Huang Yanru , Zheng Wenying , Lu Mei 
Published: June 2022

We aimed to explore the genotypic and phenotypic characteristics of neonatal-onset inflammatory bowel disease (IBD) with combined immunodeficiency due to TTC7A mutation. We examined the clinical manifestations, imaging results, endoscopic and histological findings, interventions, and prognosis of a proband with neonatal-onset IBD and performed biochemical analyses, whole-exome sequencing (WES), and in silico analysis. Our proband developed severe early-onset diarrhea, malnutrition, electrolyte imbalance, dehydration, and recurrent infections after birth. Radiographic and ultrasonic images showed no specific manifestations. Endoscopic and histological examination revealed chronic inflammation. Immune function examination indicated immunodeficiency. WES identified compound heterozygous TTC7A mutations (c.2355+4A&gt;G, c.643G&gt;T) in the proband. In the expression analysis, no abnormal splicing in the TTC7A sequence was observed due to the c.2355+4A&gt;G mutation; however, the mRNA expression was reduced. The proband’s condition did not improve after treatment with methylprednisolone or leflunomide. The proband died when treatment was stopped at the age of 5 months and 19 days. Compound heterozygous mutations (c.2355+4A&gt;G, c.643G&gt;T) in the TTC7A gene are described and verified for the first time. Our report expands the phenotypic spectrum of TTC7A mutations and the genotypic spectrum of very early-onset IBD with combined immunodeficiency.