bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analytical Method for Quantification of Several Phthalate Acid Esters by Gas Chromatography‐Mass Spectrometry in Coffee Brew Samples
Authors: Amorello Diana , Indelicato Roberta , Barreca Salvatore , Orecchio Santino , Orecchio Silvia 
Published: December 2022

AbstractSeveral phthalate acid esters (PAEs), often called phthalate esters or phthalates, are substances classified as harmful due to their carcinogenic and mutagenic properties, and moreover, as dangerous for humans because they interfere with the endocrine system. In general, phthalic esters are used as plasticizers for different polymers and more other consumer products. In the present study, we describe a simple method to quantify PAEs in coffee brew using a liquid‐liquid extraction without purification processes through analysing the obtained organic phase by GCMS in the single ion monitoring mode. The totals of single PAEs, in coffee brew samples analysed by us, are in the range of 159–5305 μg L−1. Considering that, on average, a person drinks three cups (total 90 mL) of the aforementioned drink per day, this will lead to the uptake of a total 14 to 477 μg of phthalates.
Proteomics‐based scoring of cellular response to stimuli for improved characterization of signaling pathway activity
Authors: Kazakova Elizaveta M. , Solovyeva Elizaveta M. , Levitsky Lev I. , Bubis Julia A. , Emekeeva Daria D. , Antonets Anastasia A. , Nazarov Alexey A. , Gorshkov Mikhail V. , Tarasova Irina A. 
Published: December 2022

AbstractOmics technologies focus on uncovering the complex nature of molecular mechanisms in cells and organisms, including biomarkers and drug targets discovery. Aiming at these tasks, we see that information extracted from omics data is still underused. In particular, characteristics of differentially regulated molecules can be combined in a single score to quantify the signaling pathway activity. Such a metric can be useful for comprehensive data interpretation to follow: (1) developing molecular responses in time; (2) potency of a drug on a certain cell culture; (3) ranking the signaling pathway activity in stimulated cells; and (4) integration of the omics data and assay‐based measurements of cell viability, cytotoxicity, and proliferation. With recent advances in ultrafast mass spectrometry for quantitative proteomics allowing data collection in a few minutes, proteomics score for cellular response to stimuli can become a fast, accurate, and informative complement to bioassays. Here, we utilized an interquartile‐based selection of differentially regulated features and a variety of schemes for quantifying cellular responses to come up with the quantitative metric for total cellular response and pathway activity. Validation was performed using antiproliferative and virus assays and label‐free proteomics data collected for cancer cells subjected to drug stimulation.
Transregional spouses, parents and children: How gender and family shape return migration in the French overseas
Authors: Haddad Marine , Caron Louise 
Published: December 2022

AbstractThis paper explores the role of migrants' family dynamics over the life cycle on their decisions to return focusing on three dimensions: relationship status, children and intergenerational solidarities. It brings a unique contribution to migration studies by investigating whether these mechanisms differ for male and female migrants. Combining two surveys (Migration Family Ageing and Trajectories and Origins) collected in the origin and destination regions, we study return behaviours of migrants born in the French Overseas departments (DOM) moving from metropolitan France back to their DOM of birth. Contrasting with traditional research which tends to restrict the analysis of family considerations to female migrants, our findings show that family experiences affect return migrations for both men and women, yet in different ways. While partnering, breaking‐up and having children affect the returns of both men and women, only female migrants are more likely to return when their parent(s) live in the DOM. This could draw back to a gendered distribution of family roles and responsibilities, but also to gendered networks with stronger ties between female migrants and their parents.
Understanding trajectories of population decline across rural and urban Europe: A sequence analysis
Authors: Newsham Niall , Rowe Francisco 
Published: December 2022

AbstractPopulation decline is projected to become widespread in Europe, with the continental population set to reverse its longstanding trajectory of growth within the next 5 years. This represents unfamiliar demographic territory. Despite this, literature on decline remains sparse and our understanding porous. Particular epistemological deficiencies stem from a lack of both cross‐national and temporal analyses of population decline. This study seeks to address these gaps through the novel application of sequence and cluster analysis techniques to examine variations in population decline trajectories since 2000 in 696 subnational areas across 33 European territories. The methodology allows for a holistic understanding of decline trajectories capturing differences in the ordering, timing, magnitude and spatial structure of population decline. We identify a typology of population decline distinguishing seven distinct pathways to depopulation and chart their geographies. Results revealed differentiated pathways of depopulation in continental subregions, with consistent and rapid declines in the east, persistent but moderate declines in central Europe, accelerating declines in the south and decelerating population declines in the west. Results also revealed differentiated patterns of depopulation across the rural–urban continuum, with urban and populous areas experiencing a deceleration in population decline, while decline accelerates or stabilises in rural areas. Small‐ and mid‐sized areas displayed heterogeneous depopulation trajectories, highlighting the importance of local contextual factors in influencing trajectories of population decline.
Nutritional status in pulmonary arterial hypertension
Authors: Kwant Chermaine T. , van der Horst Frans A. L. , Bogaard Harm J. , de Man Frances S. , Vonk Noordegraaf Anton 
Published: December 2022

AbstractNutritional deficiencies have been described in patients with pulmonary arterial hypertension (PAH), such as in iron and vitamin D. However, an extensive description of vitamin and mineral status is lacking and until now there is no data on dietary intake in PAH patients. We analyzed blood samples and determined nutritional intake using a food frequency questionnaire (HELIUS) in a cohort of prevalent PAH patients at a single center in Amsterdam, the Netherlands. Quality of life (QoL) was assessed by the SF‐36 questionnaire. In total, 37 patients were included (6 males, 31 females; 48 ± 16 years). The dietary intake of sugar was above 25 g in 87% of the patients and fluid intake was above 1500 ml in 78% of the patients. Sodium intake was below 1800 mg in the majority (56%) of the patients. Sugar and fluid intake were linear related. We confirm previously observed deficiencies of iron and vitamin D in our study population. In addition, we observed a functional vitamin B12 deficiency in 29% of patients, which coincided with an increased expression of methylmalonic acid. 60% of patients had a low vitamin K1 status (<0.8 nmol/L). Finally, 40% of patients had selenium levels below <100 μg/L and low selenium levels associated with reduced vitality in these patients. Besides the known deficiencies in iron and vitamin D levels, we observed in a subset of patients signs of vitamin B12, vitamin K1 and selenium deficiencies. There is room for improving dietary intake. Future research aims to demonstrate the clinical importance and reveal the effect of nutritional interventions.
Cognitive and behavioral processes predict anxiety and depression in patients with pulmonary hypertension
Authors: Rawlings Gregg H. , Thompson Andrew R. , Armstrong Iain , Novakova Barbora , Beail Nigel 
Published: December 2022

AbstractEmotional and psychological difficulties cannot fully be explained by disease‐related factors in people with pulmonary hypertension (PH). This study examined the relationship between anxiety, depression, demographic, objective and subjective PH factors, and self‐reported cognitive and behavioral processes, which have been associated with mood in clinical and nonclinical samples. This is a secondary analysis of baseline data from 77 adults with PH who took part in a randomized controlled trial of a self‐help intervention targeting anxiety in PH. Participants completed self‐report measures including: demographic (age, gender, ethnicity, education, employment) and clinical questionnaire (PH diagnosis, functional class, years since diagnosis), depression (PHQ‐9), anxiety (GAD‐7), health‐related quality of life (emPHAsis‐10), dyspnea (D12), and cognitive and behavioral processes (CBP‐Q) scale. Data were analyzed using correlational and regression analyses. Overall, 70% and 63% of participants scored above the clinical cut off for anxiety and depression, respectively. Demographics were not associated with anxiety or depression. PH‐related factors were correlated with depression but not anxiety. A multiple regression analysis suggested dyspnea and cognitive processes significantly predicted anxiety whereas behavioral processes were not a unique predictor. In contrast, dyspnea and behavioral processes predicted depression whereas cognitive processes did not. While a body of evidence exists demonstrating people with PH are more likely to experience anxiety and depression, less is known about factors that cause and maintain these disorders. Findings highlight the significance of subjective factors that could be a target for screening and psychological treatments for emotional difficulties, such as cognitive behavioral therapy.
Vagus nerve‐guided (modified Bai‐Jiang‐style) robotic‐assisted laparoscopic splenectomy and azygoportal disconnection
Authors: Bai Dou‐Sheng , Jin Sheng‐Jie , Zhou Bao‐Huan , Xiang Xiao‐Xing , Qian Jian‐Jun , Zhang Chi , Gao Tian‐Ming , Jiang Guo‐Qing 
Published: December 2022

AbstractBackgroundHow to precisely protect and preserve anterior and posterior vagal trunks and all their branches during the procedure of splenectomy and azygoportal disconnection is studied rarely. We firstly developed a vagus nerve‐guided robotic‐assisted laparoscopic splenectomy and azygoportal disconnection (VGRSD). The aim of this study was to evaluate whether VGRSD is feasible and safe and to determine whether VGRSD can effectively eliminate postoperative digestive system complications by protecting vagal nerve precisely.MethodIn this prospective clinical study, 10 cirrhotic patients with oesophagogastric variceal bleeding and hypersplenism who underwent VGRSD between January 2022 and March 2022 were gathered, and compared with a retrospective cohort who received a part of the vagus nerve‐preserving robotic‐assisted laparoscopic splenectomy and azygoportal disconnection (VPRSD). They were all followed up for 6 months.ResultsIn VGRSD group, the operation time was 173.5 ± 16.2 min, blood loss was 68.0 ± 39.1 ml, VAS pain score on the first day was 1.9 ± 0.7, and the postoperative hospital stay was 7.7 ± 0.7 days. There was no incisional complications, pneumonia, gastric fistula, pancreatic fistula, and abdominal infection. No patients suffered from diarrhoea, delayed gastric emptying, and epigastric fullness. Compared with VPRSD, operation time was significantly longer for VGRSD (p < 0.05). However, VGRSD was significantly associated with less diarrhoea and shorter postoperative hospital stay (all p < 0.05).ConclusionVGRSD procedure is not only technically feasible and safe, it also effectively eliminate postoperative digestive system complications.Trial registrationWe registered our research at https://www.clinicaltrials.gov/. The name of research registered is ‘Vagus Nerve‐guided Robotic‐assisted Splenectomy and Azygoportal Disconnection’. The trial registration identifier at clinicaltrials.gov is NCT05300516.
Fully distributed event‐driven cooperation with unknown parameters under directed graphs
Authors: Liu Shu , Sun Jiayue , Zhang Huaguang 
Published: December 2022

AbstractIn this article, a novel fully distributed dynamic event‐driven strategy is designed for linear multi‐agent systems (MASs) containing unknown parameters under general directed graphs. Each agent can achieve consensus asymptotically by communicating with its neighbors and does not need to use global information, so the proposed dynamic event‐driven algorithm can work in a fully distributed manner. Existing fully distributed event‐based consensus works rely on two or more event monitoring conditions. Too much event monitoring logic will put an extra computational burden on the MASs; instead, for the first time, this article proposes a fully distributed event‐driven strategy with a single event monitoring condition under directed graphs. In addition, the proposed strategy (adaptive control law and event monitoring condition) does not involve the dynamics parameters of MASs and provides better applicability. Finally, we rule out Zeno behavior by showing that any adjacent event interval for each agent is greater than zero. The simulations verify our results.
Network aspects of integrating 5G and satellite communication
Authors: Norp Toon , Fine Jean‐Yves , Djapic Relja 
Published: December 2022

SummarySince 2017, 3rd Generation Partnership Program (3GPP) is working on integration of satellite communication in 3GPP. This paper discusses the results of the work on service and network architecture aspects in 3GPP Technical Specification Group (TSG) Service and System Aspects (SA) and 3GPP TSG Core Networks and Terminals (CT). This paper does not discuss radio aspects as are specified in 3GPP TSG radio access network (RAN). 3GPP first specified requirements and use cases for satellite access. Subsequently, architecture and protocol specifications were created for integration scenarios, direct access, network selection, mobility management, and satellite backhaul with quality of service (QoS). Also, impacts of regulatory aspects on satellite integration have been discussed in 3GPP. With the completion of Release 17, 3GPP specifications are now ready for implementation of integrated 5G satellite networks. 3GPP will continue with further development of satellite integration in Release 18 and Release 19.
Swarming Magnetic Microrobots for Pathogen Isolation from Milk
Authors: Mayorga‐Martinez Carmen C. , Castoralova Marketa , Zelenka Jaroslav , Ruml Tomas , Pumera Martin 
Published: December 2022

AbstractBovine mastitis produced by Staphylococcus aureus (S. aureus) causes major problems in milk production due to the staphylococcal enterotoxins produced by this bacterium. These enterotoxins are stable and cannot be eradicated easily by common hygienic procedures once they are formed in dairy products. Here, magnetic microrobots (MagRobots) are developed based on paramagnetic hybrid microstructures loaded with IgG from rabbit serum that can bind and isolate S. aureus from milk in a concentration of 3.42 104 CFU g−1 (allowable minimum level established by the United States Food and Drug Administration, FDA). Protein A, which is present on the cell wall of S. aureus, selectively binds IgG from rabbit serum and loads the bacteria onto the surface of the MagRobots. The selective isolation of S. aureus is confirmed using a mixed suspension of S. aureus and Escherichia coli (E. coli). Moreover, this fuel‐free system based on magnetic robots does not affect the natural milk microbiota or add any toxic compound resulting from fuel catalysis. This system can be used to isolate and transport efficiently S. aureus and discriminate it from nontarget bacteria for subsequent identification. Finally, this system can be scaled up for industrial use in food production.
Validation of stricture length, duration and obstructive symptoms as predictors for intervention in ileal stricturing Crohn's disease
Authors: El Ouali Sara , Baker Mark E. , Lyu Ruishen , Fletcher Joel G. , Bruining David H. , Holubar Stefan D. , Click Benjamin , Qazi Taha , Cohen Benjamin L. , Rieder Florian ,   Stenosis Therapy and Anti‐Fibrotic Research (STAR) Consortium
Published: December 2022

AbstractBackgroundRisk factors for intervention in terminal ileal (TI) stricturing Crohn's disease (CD) are poorly defined. Novel and rigorous definitions for TI strictures recently became available.ObjectiveWe aimed to describe the rates of symptoms or need for endoscopic balloon dilation (EBD) or surgery as well as risk factors of progression in a well‐defined stricturing CD cohort.MethodsConsecutive adult patients with non‐penetrating stricturing TI CD, as defined by centrally‐read magnetic resonance enterography CONSTRICT criteria, were separated into a derivation and validation cohort. Clinical and imaging characteristics were collected following prespecified scoring conventions. Primary outcome was a composite endpoint of EBD or surgery (“intervention”). Multivariable analysis was performed.ResultsEighty‐six patients (48.8% female, median age 36 years) met selection criteria, 17.4% had prior EBD, 59.3% previously received biologics and 58.1% of strictures were anastomotic. Median follow‐up was 63.4 [95% CI: 57, 68.9] months. In the derivation cohort, at 12 and 48 months, 26% and 45% of patients had intervention, respectively. Multivariable analysis showed obstructive symptoms (Hazard ratio [HR] 1.444; 95% CI 1.126–1.852), stricture duration (HR 0.974; 95% CI, 0.954–0.995) and length (HR 1.039; 95% CI, 1.011–1.069) predicted intervention. The concordance index for split‐sample validation was 0.74 and 0.67, respectively. Biologics were not associated with intervention. An online risk calculator was constructed.ConclusionIn patients with TI stricturing CD, 26% and 45% required intervention at 1 and 4 years. Obstructive symptoms, stricture duration and length were independent and validated predictors of the need for intervention. These findings are important for clinical practice and aid in the design of future trials for CD strictures.
New perspectives on historical climatology
Authors: White Sam , Pei Qing , Kleemann Katrin , Dolák Lukáš , Huhtamaa Heli , Camenisch Chantal 
Published: December 2022

AbstractHistorical climatology is an interdisciplinary field of research encompassing the reconstruction of past climate and weather from written sources and artifacts, as well the application of climate reconstructions to the study of human history. Historical climatology has grown in recent years, and this growth has brought both insights and challenges. Research has expanded into new regions and periods and diversified into novel sources, methods, and interdisciplinary collaborations. At the same time, the heterogeneity of evidence and approaches has complicated the integration of multiple climate and weather reconstructions. Moreover, the diversity of disciplinary perspectives, terminologies, and perspectives can create miscommunication among scholars in the field, particularly on issues of historical knowledge and causation. Innovative approaches in the field, including Bayesian methods, may help address these challenges.This article is categorized under:
Climate, History, Society, Culture > Disciplinary Perspectives
Climate, History, Society, Culture > World Historical Perspectives
Assessing Impacts of Climate Change > Representing Uncertainty
The Social Status of Climate Change Knowledge > Knowledge and Practice
Design of a new polyethersulfone nanofiltration membrane with anti‐fouling properties using supported protic ionic liquid modification for dye/salt removal
Authors: Gholami Foad , Ghanizadeh Ghader , Zinatizadeh Ali Akbar , Zinadini Sirus , Masoumbeigi Hossein 
Published: December 2022

AbstractFacile techniques to fabricate the nanofiltration membranes with ideal molecular sieving is one of the most interesting subjects in membrane separation technology. In this study, the application of modified graphene oxide (GO) with triethylenetetramine (TETA), CuFe2O4, and acetic acid (AC) (supported GO‐TETA‐CuFe2O4@AC) as a supported protic ionic liquid (PIL) modifier for polyethersulfone (PES) membrane was evaluated to approve the improvement of anti‐fouling properties and wastewater rejection of the fabricated membranes. To enhance the key properties of graphene oxide, it was modified by hydrophilic nanomaterials (TETA‐CuFe2O4). High flux and promising flux recovery ratio (up to 95% compared to the unmodified membrane) can be observed in the modified membranes. The modified membranes by GO‐TETA‐CuFe2O4@AC were studied at optimum concentrations (0.5 wt.%) for salt rejection and different dyes. The obtained data indicated that the modified membranes by GO‐TETA‐CuFe2O4@AC indicated higher salt removal (up to 97% for BaCl2 than the unmodified membrane), which was related to the efficient modification. The obtained pure water flux (PWF) for bare and optimal modified membrane from 13.11 to 27.87 kg/m2·h, respectively. To exact evaluate the effect of membrane modification on performance examination, the modified membranes were evaluated for chlorine resistance testing. This study aimed to develop cost‐effective nanofiltration (NF) membranes with high anti‐fouling properties and to determine the maximum filtration capacity of in‐time dyes and salts in effluents.Practitioner Points
A GO‐TETA‐CuFe2O4 mixed matrix membrane was prepared for removal of salts and dyes.
The effect of GO‐TETA‐CuFe2O4 enhanced the hydrophilicity and porosity.
The membrane exhibited superior antifouling properties and ions rejection.
Effects of a modern exhibit design on captive tiger welfare
Authors: Smith Kirsten D. , Snider Richard J. , Dembiec Daniel P. , Siegford Janice M. , Ali Ahmed B. 
Published: December 2022

AbstractOffering captive animals larger, more complex spaces are thought to benefit their welfare. To this end, some zoos use trail systems linked to several enclosures. Since little is known about the effects of such designs on the welfare of captive carnivores specifically, we timed the behaviors exhibited by four tigers (Panthera tigris [Linnaeus]) given access to three exhibit configurations: one exhibit only (E, baseline); one exhibit and approximately 19 m2 of trail (ET); and two exhibits connected by approximately 46 m2 of trail (E2T). Behaviors were recorded during 1‐h AM, Noon, and PM periods in Phase I (2017), and 2‐h AM and PM periods in Phase II (2018). Percentages of behavior occurrence were analyzed using generalized linear mixed models (GLMM), with treatment and time of day as fixed effects. Tigers were least active at noon (Phase I), while active behaviors were prevalent during mornings and afternoons in both Phases. In Phase II (E2T vs. E), active and exploratory behaviors such as sniffing increased, while pacing and inactivity decreased (all p ≤ .001). We also examined nocturnal tiger movement using infrared motion‐activated cameras. In parallel with diurnal observations, tiger activity in E2T greatly exceeded that in E. Nocturnal movement was most pronounced from 1800 to 2200 and least frequent from 0100 to 0400, closely matching patterns observed in the wild. Results indicate that offering tigers voluntary access to larger and more complex spaces stimulates natural behaviors and decreases stereotypical behaviors.