DYNAMICS OF PROAND ANTI-INFLAMMATORY PROSTAGLANDINS IN CASES OF GENERALIZED PERIODONTITIS ACCOMPANIED BY DIFFERENT TYPES OF REACTIVITY OF THE BODY
Authors: Yarov Yu.Yu. , Silenko Yu.I. 
Published: June 2022

In terms of socio-economic significance, among the most burning problems of modern dentistry are periodontal diseases. According to modern ideas, in generalized periodontitis, one of the main mechanisms of destruction of the alveolar bone is considered to be an increase in prostaglandin levels. Data on the detection of receptors for PG E2 on the membranes of preosteoblasts and osteoclasts are described. Taking into consideration the effect of prostaglandins F2α and E2 on microvascular and cellular reactions in tissues, we can predict their important role in the development of healing and stabilization of the pathological process in periodontal tissues.
The aim of this research was to study the dynamics of proand anti-inflammatory prostaglandins (F2α and E2) in the blood of patients with generalized periodontitis accompanied by normo-, hyperand hyporeactivity of the body after patch surgery.
Materials and methods of research. 216 people aged 45 between 55 years old with the diagnosis of generalized periodontitis were examined. Depending on the condition of reactivity of the body, the patients were divided into three groups: 11 normoreaction; 2hyperreaction; 3 hyporeaction. After initial therapy, patch surgery was performed according to the indications. Blood sampling was performed after surgery on the 1st, 2nd, 4th, 6th and 9th day. The content of prostaglandins F2α and E2 was determined by radioimmunoassay.
Statistical processing of the obtained digital data was performed using the computer program Statistica 8.0 (STA862D175437Q).
Results of the research. The results of this study showed that for patients with generalized periodontitis accompanied by normoreactivity of the body after surgery by an imbalance between the proand antiinflammatory fractions of eicosanoids is typical. On the 1st day, the value of the PG correlation increased, reaching its maximum level on the 2nd day, exceeding the initial value by 1.8 times (p <0.05). This is due to a sharp increase in the content of PG F2α in the blood of patients with generalized periodontitis accompanied by falling concentrations of PG E2. Subsequently, the alignment of the primary balance of prostaglandins was observed on the 9th day, the correlation of PG F2α / PG E2 reached normal values. The change in the correlation of PG F2α / PG E2 in patients with generalized periodontitis accompanied by hyperreactivity of the body was monophasic in nature with its maximum value on the 1st day after surgery. The value of the correlation increased 1.4 times compared to the original (p <0,05) one. On the 2nd day, there was a significant decrease in the correlation of PG F2α / PG E2 to the value below the initial (0.18 ± 0.04). Subsequently, beginning with the 6th day, in the blood of patients with GP with hyperreactivity of the body, the correlation of eicosanoids was close to the initial one. The change in the correlation of PG F2α / PG E2 in patients with generalized periodontitis accompanied by hyporeactivity of the body was monophasic in nature with its maximum values on the 2-4th day after surgery. The value of the correlation became 1.6 times higher compared to the original (p <0,05) one. Subsequently, beginning with the 6th day, in the blood of patients with GP with hyporeactivity of the body the correlation of eicosanoids close to the original was revealed.
Conclusion. Correction of altered parameters in patients with generalized periodontitis with impaired (hyperand hyporeactivity) of the body with bringing them to values, typical for normoreactivity is considered to be a condition for optimizing the healing of mucosal wounds after surgery and further stabilization of the process in periodontal tissues.