bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analysis of historical selection in winter wheat
Authors: Yang Chin Jian , Ladejobi Olufunmilayo , Mott Richard , Powell Wayne , Mackay Ian 
Published: July 2022

AbstractKey MessageModeling of the distribution of allele frequency over year of variety release identifies major loci involved in historical breeding of winter wheat.AbstractWinter wheat is a major crop with a rich selection history in the modern era of crop breeding. Genetic gains across economically important traits like yield have been well characterized and are the major force driving its production. Winter wheat is also an excellent model for analyzing historical genetic selection. As a proof of concept, we analyze two major collections of winter wheat varieties that were bred in Western Europe from 1916 to 2010, namely the Triticeae Genome (TG) and WAGTAIL panels, which include 333 and 403 varieties, respectively. We develop and apply a selection mapping approach, Regression of Alleles on Years (RALLY), in these panels, as well as in simulated populations. RALLY maps loci under sustained historical selection by using a simple logistic model to regress allele counts on years of variety release. To control for drift-induced allele frequency change, we develop a hybrid approach of genomic control and delta control. Within the TG panel, we identify 22 significant RALLY quantitative selection loci (QSLs) and estimate the local heritabilities for 12 traits across these QSLs. By correlating predicted marker effects with RALLY regression estimates, we show that alleles whose frequencies have increased over time are heavily biased toward conferring positive yield effect, but negative effects in flowering time, lodging, plant height and grain protein content. Altogether, our results (1) demonstrate the use of RALLY to identify selected genomic regions while controlling for drift, and (2) reveal key patterns in the historical selection in winter wheat and guide its future breeding.
Routine contrast-enhanced CT is insufficient for TNM-staging of duodenal adenocarcinoma
Authors: Litjens G. , van Laarhoven C. J. H. M. , Prokop M. , van Geenen E. J. M. , Hermans J. J. 
Published: July 2022

Abstract
Purpose
Adequate TNM-staging is important to determine prognosis and treatment planning of duodenal adenocarcinoma. Although current guidelines advise contrast-enhanced CT (CECT) for staging of duodenal adenocarcinoma, literature about diagnostic tests is sparse.

Methods
In this retrospective single-center cohort study, we analyzed the real life performance of routine CECT for TNM-staging and the assessment of resectability of duodenal adenocarcinoma. Intraoperative findings and pathological staging served as reference standard for resectability, T-, and N-staging. Biopsies, 18FDG-PET-CT, and follow-up were used as the reference standard for M-staging.

Results
Fifty-two consecutive patients with duodenal adenocarcinoma were included, 26 patients underwent resection. Half of the tumors were isodense to normal duodenum on CECT. The tumor was initially missed in 7/52 patients (13%) on CECT. The correct T-stage was assigned with CECT in 14/26 patients (54%), N-stage in 11/26 (42%), and the M-stage in 42/52 (81%). T-stage was underestimated in (27%). The sensitivity for detecting lymph node metastases was only 24%, specificity was 78%. Seventeen percent of patients had indeterminate liver or lung lesions on CECT. Surgery with curative intent was started in 32 patients, but six patients (19%) could not be resected due to unexpected local invasion or metastases.

Conclusion
Radiologists and clinicians have to be aware that routine CECT is insufficient for staging and determining resectability in patients with duodenal adenocarcinoma. CECT underestimates T-stage and N-stage, and M-stage is often unclear, resulting in futile surgery in 19% of patients. Alternative strategies are required to improve staging of duodenal adenocarcinoma. We propose to combine multiphase hypotonic duodenography CT with MRI.
Postoperative Chemotherapy is Associated with Improved Survival in Patients with Node‐Positive Pancreatic Ductal Adenocarcinoma After Neoadjuvant Therapy
Authors: Ivey Gabriel D. , Shoucair Sami , Delitto Daniel J. , Habib Joseph R. , Kinny‐Köster Benedict , Shubert Christopher R. , Lafaro Kelly J. , Cameron John L. , Burns William R. , Burkhart Richard A. , Thompson Elizabeth L. , Narang Amol , Zheng Lei , Wolfgang Christopher L. , He Jin 
Published: July 2022

AbstractBackgroundPostoperative chemotherapy following pancreatic cancer resection is the standard of care. The utility of postoperative chemotherapy for patients who receive neoadjuvant therapy (NAT) is unclear.MethodsPatients who underwent pancreatectomy after NAT with FOLFIRINOX or gemcitabine‐based chemotherapy for non‐metastatic pancreatic adenocarcinoma (2015–2019) were identified. Patients who received less than 2 months of neoadjuvant chemotherapy or died within 90 days from surgery were excluded.ResultsA total of 427 patients (resectable, 22.2%; borderline resectable, 37.9%; locally advanced, 39.8%) were identified with the majority (69.3%) receiving neoadjuvant FOLFIRINOX. Median duration of NAT was 4.1 months. Following resection, postoperative chemotherapy was associated with an improved median overall survival (OS) (28.7 vs. 20.4 months, P = 0.006). Risk‐adjusted multivariable modeling showed negative nodal status (N0), favorable pathologic response (College of American Pathologists score 0 & 1), and receipt of postoperative chemotherapy to be independent predictors of improved OS. Regimen, duration, and number of cycles of NAT were not significant predictors. Thirty‐four percent (60/176) of node‐positive and 50.1% (126/251) of node‐negative patients did not receive postoperative chemotherapy due to poor functional status, postoperative complications, and patient preference. Among patients with node‐positive disease, postoperative chemotherapy was associated with improved median OS (27.2 vs. 10.5 months, P < 0.001). Among node‐negative patients, postoperative chemotherapy was not associated with a survival benefit (median OS, 30.9 vs. 36.9 months; P = 0.406).ConclusionAlthough there is no standard NAT regimen for patients with pancreatic cancer, postoperative chemotherapy following NAT and resection appears to be associated with improved OS for patients with node‐positive disease.
Fruit and vegetable consumption and depression symptoms in young women: results from 1973 to 1978 cohort of the Australian Longitudinal Study on Women’s Health
Authors: Dharmayani Putu Novi Arfirsta , Mishra Gita D. , Mihrshahi Seema 
Published: July 2022

Abstract
Purpose
Growing evidence suggests that specific food groups may play an important role in improving mental health. However, very few studies explored the association between individual dietary factors and depression symptoms by following a large cohort of individuals over a long period. We examined the differential effects of fruit and vegetables in relation to depression symptoms over a 15-year follow-up period in the 1973–78 cohort of the Australian Longitudinal Study on Women’s Health.

Methods
Fruit and vegetable consumption was assessed using short questions. The Center for Epidemiologic Studies Depression-10 scale with a cut off ≥ 10 indicated depressive symptoms. Multiple imputations with generalised estimating equations models were performed to estimate odds ratio of depression symptoms according to fruit and vegetable consumption.

Results
A total of 4241 participants with a mean age of 27.6 (SD 1.45) years at baseline were followed up at five surveys (2003–2018). Fruit and vegetable intake (≥ 2 servings) was cross-sectionally associated with lower odds of depressive symptoms. In longitudinal analysis, a higher intake of fruit (≥ 4 servings) and vegetable (≥ 5 servings) was consistently associated with lower odds of depressive symptoms, with a 25% lower odds (OR 0.75; 95% CI 0.57, 0.97; p = 0.031) and a 19% lower odds (OR 0.81; 95% CI 0.70, 0.94; p = 0.007) than consuming one serve or less fruit and vegetable, respectively.

Conclusion
These results suggest that a higher intake of fruit and vegetables was associated with a lower risk of depression symptoms over 15 years from a population-based prospective study of Australian women.
A novel method for monitoring abdominal compliance to optimize insufflation pressure during laparoscopy
Authors: Sterke Frank , van Weteringen Willem , Ventura Lorenzo , Milesi Ilaria , Wijnen René M. H. , Vlot John , Dellacà Raffaele L. 
Published: July 2022

Abstract
Background
Abdominal compliance describes the ease of expansion of the abdominal cavity. Several studies highlighted the importance of monitoring abdominal compliance (Cab) during the creation of laparoscopic workspace to individualize the insufflation pressure. The lack of validated clinical monitoring tools for abdominal compliance prevents accurate tailoring of insufflation pressure. Oscillometry, also known as the forced oscillation technique (FOT), is currently used to measure respiratory mechanics and has the potential to be adapted for monitoring abdominal compliance. This study aimed to define, develop and evaluate a novel approach which can monitor abdominal compliance during laparoscopy using endoscopic oscillometry.

Materials and methods
Endoscopic oscillometry was evaluated in a porcine model for laparoscopy. A custom-built insufflator was developed for applying an oscillatory pressure signal superimposed onto a mean intra-abdominal pressure. This insufflator was used to measure the abdominal compliance at insufflation pressures ranging from 5 to 20 hPa (3.75 to 15 mmHg). The measurements were compared to the static abdominal compliance, which was measured simultaneously with computed tomography imaging.

Results
Endoscopic oscillometry recordings and CT images were obtained in 10 subjects, resulting in 76 measurement pairs for analysis. The measured dynamic Cab ranged between 0.0216 and 0.261 L/hPa while the static Cab based on the CT imaging ranged between 0.0318 and 0.364 L/hPa. The correlation showed a polynomial relation and the adjusted R-squared was 97.1%.

Conclusions
Endoscopic oscillometry can be used to monitor changes in abdominal compliance during laparoscopic surgery, which was demonstrated in this study with a comparison with CT imaging in a porcine laparoscopy model. Use of this technology to personalize the insufflation pressure could reduce the risk of applying excessive pressure and limit the drawbacks of insufflation.
Serum interleukin-23 levels: relation to depression, anxiety, and disease activity in psoriatic arthritis patients
Authors: Tabra Samar Abdalhamed , abd Elghany Salwa Elmorsy , Amer Reham A. , Fouda Mohamed H. , Abu-Zaid Mohammed Hassan 
Published: July 2022

Abstract

Objectives
Assessment of serum levels of IL-23 in PsA patients and its correlation with depression, anxiety, and disease activity.

Methods
Eighty psoriatic arthritis (PsA) patients and eighty healthy volunteers matched for age and gender were included in this observational case–control study. All participants suspected to detailed history, clinical assessment, PsA activity using Disease Activity Index for Psoriatic Arthritis (DAPSA) score, the severity and extent of psoriasis was assessed by the Psoriasis Area and Severity Index (PASI), and ultrasonographic assessments of the entheses were examined according to the Madrid Sonographic Enthesitis Index (MASEI). Depression and anxiety were assessed by Hospital Anxiety and Depression Scale (HADS). Serum IL-23 was measured and correlated with disease activity, depression, and anxiety.

Results
There was no significant difference between patients and controls regarding demographic data. Thirty-six PsA patients (45%) had anxiety and 28 patients (35%) had depression, while in the control group, 16 persons (20%) had anxiety and 12 (15%) had depression, with significant differences between the 2 groups (p < 0.0001). There were significant differences in HADS anxiety and depression scores between patients and controls with significant positive correlations between HADS depression, anxiety scores and IL-23, DAPSA, PASI, and MASEI scores (p < 0.05). IL-23 was positively correlated with DAPSA, PASI, and HADS scores; we observed that interleukin 23, higher DAPSA, and PASI were independently associated with depression and anxiety.

Conclusion
Serum interleukin-23 levels were elevated in PsA patients and were found to be correlated with depression, anxiety, and disease activity.

Key Points• Psoriatic arthritis is a multidimensional disorder with psychiatric drawbacks.• Interleukin-23 is a proinflammatory cytokines that was correlated with depression and anxiety in PsA patients.• Interleukin-23 was correlated with disease activity in PsA.• Depression and anxiety were positively correlated with disease activity in PsA.
Build, buy, or partner? A systematic literature review on the choice between alternative modes of growth
Authors: Ego Philipp 
Published: July 2022

AbstractWhen pursuing growth opportunities, organizations can, most fundamentally, choose between three different modes: internal development, mergers and acquisitions, and partnerships. Strategic management research investigates the decision of whether to “build, buy, or partner” and its determining factors from various theoretical perspectives, which led to the emergence of related, but largely independent, research streams. As such, this review consolidates the scattered literature landscape and provides a comprehensive understanding of the antecedents associated with the choice of corporate growth modes. To do so, an integrative research framework is proposed that encompasses internal, external, and decision-related factors. Based on this framework, the review provides a synthesized overview and critical assessment of 74 past empirical contributions and develops a detailed roadmap to guide future research.
Lernmaterialien im Sportunterricht
Authors: Wibowo Jonas , Schütt Marie-Luise , Bükers Frederik 
Published: July 2022

ZusammenfassungLernmaterialien im Sportunterricht wird das Potenzial zugeschrieben, die Lernprozesse von Schüler:innen fördern zu können. Dies bezieht sich auf fachliche Aspekte wie das Aneignen komplexer Bewegungen oder die Entwicklung von Lösungen zu Bewegungsproblemen. Mit Lernmaterialien werden aber auch überfachliche Ziele wie die Förderung von Selbstständigkeit, Motivation und Kooperationsfähigkeit in Verbindung gebracht. In dem vorliegenden Beitrag sollen ausschließlich potenzielle Barrieren von Lernmaterialien für fachliche Lernprozesse dargestellt und Kriterien für zugängliche Lernmaterialien formuliert werden. Dazu wird zunächst eine fachdidaktische Perspektive eingenommen, und es werden Barrieren aufgrund unpassender fachlicher Anforderungen und unpassender fachlicher Unterstützung dargestellt. Außerdem werden aus der Perspektive des Multimedialernens eine unnötige Informationsverarbeitung und eine suboptimale Informationsdarbietung als Barrieren von Lernmaterialien im Sportunterricht aufgegriffen. Zuletzt wird mit Fokus auf die visuelle Gestaltung die Perspektive der Pädagogik bei Beeinträchtigung des Sehens berücksichtigt.
Electronic Health Records and Antimicrobial Stewardship Research: a Narrative Review
Authors: Rezel-Potts Emma , Gulliford Martin 
Published: July 2022

Abstract

Purpose of Review
This review summarises epidemiological research using electronic health records (EHR) for antimicrobial stewardship.

Recent Findings
EHRs enable surveillance of antibiotic utilisation and infection consultations. Prescribing for respiratory tract infections has declined in the UK following reduced consultation rates. Reductions in prescribing for skin and urinary tract infections have been less marked. Drug selection has improved and use of broad-spectrum antimicrobics reduced. Diagnoses of pneumonia, sepsis and bacterial endocarditis have increased in primary care. Analytical studies have quantified risks of serious bacterial infections following reduced antibiotic prescribing. EHRs are increasingly used in interventional studies including point-of-care trials and cluster randomised trials of quality improvement. Analytical and interventional studies indicate patient groups for whom antibiotic utilisation may be more safely reduced.

Summary
EHRs offer opportunities for surveillance and interventions that engage practitioners in the effects of improved prescribing practices, with the potential for better outcomes with targeted study designs.
Management of hand osteoarthritis: from an US evidence-based medicine guideline to a European patient-centric approach
Authors: Fuggle Nicholas , Bere Nathalie , Bruyère Olivier , Rosa Mario Manuel , Prieto Yerro María Concepción , Dennison Elaine , Dincer Fitnat , Gabay Cem , Haugen Ida K. , Herrero-Beaumont Gabriel , Hiligsmann Mickaël , Hochberg Marc C. , Laslop Andrea , Matijevic Radmila , Maheu Emmanuel , Migliore Alberto , Pelletier Jean-Pierre , Radermecker Régis Pierre , Rannou François , Uebelhart Brigitte , Uebelhart Daniel , Veronese Nicola , Vlaskovska Mila , Rizzoli René , Mobasheri Ali , Cooper Cyrus , Reginster Jean-Yves 
Published: July 2022

AbstractHand osteoarthritis is the most common joint condition and is associated with significant morbidity. It is of paramount importance that patients are thoroughly assessed and examined when complaining of hand stiffness, pain, deformity or disability and that the patient’s concerns and expectations are addressed by the healthcare professional. In 2019 the American College of Rheumatology and Arthritis Foundation (ACR/AF) produced guidelines which included recommendations for the treatment of hand osteoarthritis. An ESCEO expert working group (including patients) was convened and composed this paper with the aim to assess whether these guidelines were appropriate for the treatment of hand osteoarthritis therapy in Europe and whether they met with the ESCEO patient-centered approach. Indeed, patients are the key stakeholders in healthcare and eliciting the patient’s preference is vital in the context of an individual consultation but also for informing research and policy-making. The patients involved in this working group emphasised the often-neglected area of aesthetic changes in hand osteoarthritis, importance of developing pharmacological therapies which can alleviate pain and disability and the need of the freedom to choose which approach (out of pharmacological, surgical or non-pharmacological) they wished to pursue. Following robust appraisal, it was recommended that the ACR/AF guidelines were suitable for a European context (as described within the body of the manuscript) and it was emphasised that patient preferences are key to the success of individual consultations, future research and future policy-making.
The effect of rapamycin and its analogues on age-related musculoskeletal diseases: a systematic review
Authors: Lin Hong , Salech Felipe , Lim Anthony , Vogrin Sara , Duque Gustavo 
Published: July 2022

Abstract
Background
Preclinical studies have shown a therapeutic role of the mechanistic/mammalian target of rapamycin complex 1 (mTORC1) inhibition with rapamycin and its analogues (rapalogues) on several age-related musculoskeletal disorders (MSKD). However, the applicability to humans of these findings is unknown.

Objective
To assess the efficacy of rapalogues on age-related MSKD in humans.

Methods
We conducted a systematic review according to the PRISMA guidelines. MEDLINE, EMBase, EMCare, and Cochrane Central Registry of Controlled Trials were searched for original studies examining the effects of rapalogues on outcomes linked to the age-related MSKD in humans. This review is registered in the PROSPERO database (University of New York; registration number CRD42020208167).

Results
Fourteen studies met the inclusion criteria and were analyzed. The effect of rapamycin and other rapalogues, including everolimus and temsirolimus, on bone, muscle and joints have been evaluated in humans; however, considerable variability concerning the subjects’ age, inclusion criteria, and drug administration protocols was identified. In bone, the use of rapamycin is associated with a decrease in bone resorption markers dependent on osteoclastic activity. In muscle, rapamycin and rapalogues are associated with a reduction in muscle protein synthesis in response to exercise. In the context of rheumatoid arthritis, rapamycin and rapalogues have been associated with clinical improvement and a decrease in inflammatory activity.

Conclusion
Although there are studies that have evaluated the effect of rapamycin and rapalogues on MSKD in humans, the evidence supporting its use is still incipient, and the clinical implication of these results on the development of osteoporosis, sarcopenia, or osteosarcopenia has not been studied, opening an interesting field for future research.
Some t-conorm-based distance measures and knowledge measures for Pythagorean fuzzy sets with their application in decision-making
Authors: Ganie Abdul Haseeb 
Published: July 2022

AbstractThe Pythagorean fuzzy sets are more robust than fuzzy sets and intuitionistic fuzzy sets in dealing with the problems involving uncertainty. To compare two Pythagorean fuzzy sets, distance measures play a crucial role. In this paper, we have proposed some novel distance measures for Pythagorean fuzzy sets using t-conorms. We have also discussed their various desirable properties. With the help of suggested distance measures, we have introduced some new knowledge measures for Pythagorean fuzzy sets. Through numerical comparison and linguistic hedges, we have established the effectiveness of the suggested distance measures and knowledge measures, respectively, over the existing measures in the Pythagorean fuzzy setting. At last, we have demonstrated the application of the suggested measures in pattern analysis and multi-attribute decision-making.
The potential for reducing non-target effects on parasitoids of Ceutorhynchus obstrictus Marsham (Coleoptera: Curculionidae) through spatially targeted insecticide applications
Authors: Hausmann Johannes , Brandes Meike 
Published: July 2022

AbstractInsecticide applications against the cabbage seedpod weevil, Ceutorhynchus obstrictus Marsham (Coleoptera: Curculionidae), in oilseed rape are conducted during the flowering of the crop. During the flowering period, many parasitoids of pest species are abundant in the crop, and therefore, the preservation of natural pest regulation mechanism is especially important. Parasitism often has a substantial mortality factor in pest populations and as far as possible, parasitoids need to be protected from harmful non-target effects of insecticides. In the present study, the effects of three different insecticidal products on the parasitism of cabbage seedpod weevil larvae were investigated. Additionally, the effects of a spatial targeting of insecticides, using conventional and dropleg application technique, were compared. This was done in field trials within a completely randomized block design and four replications at one trial site in 2019 and two sites in 2020. The parasitoid species Trichomalus perfectus Walker and Mesopolobus morys Walker (both Hymenoptera: Pteromalidae) were abundant in almost equal shares in 2019, whereas M. morys was the most important species in 2020. Only in 2019 were harmful effects of the insecticide Biscaya (a.i. thiacloprid) on parasitism rates of C. obstrictus larvae observed. Clear benefits, due to spatial targeting of insecticides using the dropleg technique on parasitoids, were not found. The harmfulness of insecticides is probably affected by properties of different insecticidal products and the temporal coincidence of parasitoid occurrence and insecticide application.