bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pattern of Emergency Presentation of Patients with Breast Cancer at the University of Benin Teaching Hospital
Authors: Akpoghor Oghenevwegba Dominic , Eghonghon Attah Raymond , Osime Odigie C. 
Published: August 2022

Background:
Breast cancer is the most common malignancy affecting women in Nigeria. Presentation is usually elective. However, some patients present as an emergency with complications of the disease and its treatment. This study aimed to capture the features of this population of patients with breast cancer presenting as an emergency.

Materials and Methods:
The study was a prospective cross-sectional study conducted between March 2021 and February 2022. All the patients with histologically diagnosed breast cancer presenting as an emergency were recruited into the study. Relevant information was retrieved and analysed.

Results:
Over the study period, 34 patients were recruited. They were all females and ages ranged between 27 and 74 years of age (mean: 45.56 ± 11.71 years), and the highest incidence was in the fifth decade of life. The first symptom in all patients was a breast lump, and the duration of disease ranged between 3 and 84 months (mean: 29.21 ± 22.38 months). The right breast was most commonly involved, and invasive ductal carcinoma (no specific type) was the commonest histologic type in 88.24% of cases. Over half of the patients seen had received no treatment after establishing the diagnosis of breast cancer. For those who received treatment, radiotherapy was the least accessed form of treatment. The most common symptoms were difficulty breathing and jaundice (29.41% each), and metastatic disease was the most common diagnosis. The duration of admission ranged between 1 and 35 days, and a mortality rate of 45.45% was recorded.

Conclusion:
The most common indication for emergency presentation in patients with breast cancer was metastatic disease.
A retrospective observational study on pheno-endotypes of severe asthma among adults attending asthma clinic in a tertiary care centre in India
Authors: Talwar Deepak , Talwar Dhruv , Jain Nitin , Prajapat Deepak , Pahuja Sourabh 
Published: August 2022

Background and Objective:
Severe asthma phenotyping based on invasive and non-invasive bio-markers assists in a better understanding of heterogeneity of clinical presentations and thereby using targeted therapies. Therefore, the current study was conducted to evaluate phenotypes based on non-invasive bio-markers of severe asthma patients attending a tertiary care hospital in North India.

Methods:
This was a retrospective, observational study conducted on the patients who visited the respiratory department of a tertiary care hospital in North India. Patients aged 18 years and above diagnosed with severe asthma were classified into distinct phenotypes, namely, atopic asthma, eosinophilic asthma, and Type 2 low asthma. Patients with their clinical and functional parameters were classified based on the levels of bio-chemical and hematological results [such as total/specific IgE, blood absolute eosinophil count (AEC)], skin prick tests, history of allergy, and the presence of allergic symptoms.

Results:
Out of total 100 severe asthmatics, the majority of the patients had an eosinophilic asthma (49%) phenotype, followed by atopic (allergic) asthma (36%) and Type 2 low asthma (15%) phenotypes. However, it was found that 29% of these patients had overlap of both atopy and eosinophilia. The atopic phenotype showed allergic symptoms, positive skin prick tests, and elevated IgE levels. The eosinophilic phenotype had high AEC (≥300 cells/uL) and low IgE (< 30 IU/ml) levels. The Type 2 low phenotype showed low AEC and IgE levels along with the absence of allergic symptoms. However, among these 100 patients, overlapping traits of both atopy and eosinophilia were labelled as overlap phenotypes. 50% of type 2 low severe asthma cases had eosinophils >150 cells/cmm and were eligible for mepolizumab.

Conclusions:
Identification of severe asthma pheno-endotypes based on simple non-invasive bio-markers is feasible in Indian settings, and it is of utmost importance for future treatment planning in these patients with available biologicals. Overlap of eosinophilic and atopic endotypes in one-third cases would challenge physicians to choose upfront appropriate biologicals in our country. Type 2 low asthma was least common with only <10% cases of severe asthma being ineligible for any biological.
Influence of Patient Satisfaction on Medication Adherence among Adult Hypertensives Attending a Health Facility in a Resource-Limited Environment in Southern Nigeria
Authors: Ofili Roy A. , Nwajei Anthony Ikechukwu , Aigbokhaode Adesuwa Queen , Owolabi Akinwumi Olayinka , Owolabi Mojisola Oluyemisi , Uzundu Emeka Christopher 
Published: August 2022

Background:
Hypertension is a noncommunicable disease known to cause serious morbidity and mortality among adult population. In Nigeria, a developing nation currently experiencing harsh economic realities, the outcome of the disease can be influenced by the effect of various components of patient satisfaction on medication adherence.

Aim:
The aim of this study was to evaluate the influence of patient satisfaction on medication adherence and BP control among adult hypertensives attending the Medical OutPatient (MOP) Clinic of the Federal Medical Centre, Asaba, with a view to identifying those aspects of care that need improvement in health care settings thereby leading to improved patient satisfaction, better medication adherence and ultimately better BP control.

Patients, Materials and Methods:
This was a cross sectional study conducted among 200 adult hypertensive patients attending the MOP Clinic of the Federal Medical Centre, Asaba, from January 15th to April 15th, 2017. A semi-structured questionnaire consisting of four sections which are: sociodemographic characteristics, Modified 4-item Morisky Medication Adherence scale, patient satisfaction levels with services, and BP measurement were used for data collection.

Results:
A greater proportion 87 (43.5%) of the respondents rated overall satisfaction with care received as very good, while 23 (11.5%) rated it as being fair. A statistically significant relationship was noticed between overall levels of satisfaction with care and medication adherence, P < 0.001. The level of BP control among the respondents was also significantly associated with medication adherence, P < 0.001.

Conclusion:
Patient satisfaction was seen to have a significant association with medication adherence but not BP control. The custodians of health should endeavor to improve patient satisfaction among patients in the hospital as this study showed improved patient satisfaction to be associated with increased patient adherence to medication with attendant better BP control.
Comparative Study of Bisacodyl Suppository Plus Antibiotics Versus Antibiotics Alone in the Prevention of Postprostate Biopsy Infection
Authors: Chinonso Odo , Obi Anselm Okwudili , Mbaeri Timothy Uzoma , Obiesie Ahuizechukwu Emmanuel , Obasi Ulebe Augustine , Okeke John Chike , Abiahu Joseph Amauzo , Ekwunife Nwofor Alexander Maduaburochukwu 
Published: August 2022

Aims:
The purpose of this study is to determine whether bisacodyl rectal suppository can reduce infective complications postprostate biopsy.

Patients, Materials and Methods:
This was a comparative cross-sectional study done at the urology unit of a tertiary hospital over 12 months. A sample size of 56 was determined using Fisher's formula. Both groups had tablets of ciprofloxacin 500 mg and metronidazole 400 mg at induction of anaesthesia and continued for three days postbiopsy at a dose of 500 mg twice daily and 400 mg thrice daily, respectively. In addition to antibiotics, those in Group 1 had 20 mg of bisacodyl (Dulcolax) suppositories given at night, starting two days before the procedure. The patients underwent digitally guided 10-core transrectal prostate biopsy on an outpatient basis. Blood and urine samples were taken for full blood count and urine culture, respectively, before surgery and three days after the biopsy. Statistical analysis was performed using the SPSS version 21.0. The level of significance was set at P < 0.05.

Results:
The mean age was 69.64 ± 9.31 with a range of 52–90 years. The peak age distribution was 70–79. In Group 1, two patients had urosepsis, one patient had urinary tract infection (UTI), and seven patients had bacteriuria, while in Group 2, four patients had urosepsis, four patients had UTI, and ten patients had bacteriuria.

Conclusions:
The addition of bisacodyl rectal suppository to antibiotics reduced the frequency of infective complications following prostate biopsy. The observed difference, however, was not statistically significant.
Gynecological Endoscopic Procedures in a Tertiary Hospital in South-West Nigeria
Authors: Fehintola Akintunde Olusegun , Awotunde Olufemi Timothy , Ogunlaja Olumuyiwa A. , Olujide Lawrence Olajire , Akinola Samuel E. , Oladeji Sunday , Aaron Olurotimi Idowu 
Published: August 2022

Background:
After several years of struggling due to many constraints, centers in Nigeria are now performing Gynecological Endoscopy (GE) procedures. This study describes the outcome of various GE procedures in patients with gynecological complaints in a tertiary hospital in South-West Nigeria.

Materials and Methods:
This study was a prospective longitudinal design. All eligible patients who had endoscopic procedures in the unit between May 2014 and April 2019 were recruited. Excluded were those who refused to take part in the study. The participants were followed up for a year. Data were collected during the preoperative, intraoperative, and postoperative periods. This data included the patient's sociodemographic characteristics, indications for the procedures, procedures carried out, and the procedures' outcome.

Results:
Of the 287 patients who had various procedures during this period, we recruited two hundred and seventy eligible patients (94.1%) for the study. We lost fourteen patients (5.2%) to follow up. One hundred and seventy-two (63.7%) had laparoscopy only. Eighty (29.6%) had hysteroscopy and laparoscopy, while the remaining 20 (6.7%) had hysteroscopy only. Thirty-eight (14.1%) were emergencies, while 125 (46.3%) were only diagnostic. Procedures carried out include hysteroscopic removal of missing intrauterine devices (6.3%) and laparoscopic tubal sterilization with Falope ring application (5.2%). We also carried out laparoscopic ovarian drilling for polycystic ovary syndrome (19.3%). Six patients (2.2%) had their surgery converted to laparotomy. We recorded no mortality.

Conclusion:
Our results showed the feasibility of GE surgery in Nigeria with an acceptable outcome. Local adaption and improvisation will ensure cost reduction and widespread use of these procedures in our setting.
Clinicopathological Factors Affecting Lymph Node Yield in Patients Undergoing Surgery in Head-and-Neck Squamous Cell Carcinoma in a Tertiary Care Center of North East India
Authors: Salvi Manisha , Bharadwaj Barasha S. , Deka Muktanjalee , Sharma Mridul , Goswami B. C. 
Published: August 2022

Abstract

Background:
Lymph node yield (LNY), number of lymph nodes recovered after neck dissection has been identified as a prognostic indicator for several cancers of non-head and neck sites as well as head-and-neck squamous cell carcinoma (HNSCC). Accurate estimation of LNY has been less evaluated in Indian settings. The purpose of this study was to estimate LNY in HNSCC patients, and to find out their association with clinicopathological factors.

Materials and Methods:
This was a single-center prospective study conducted on patients diagnosed with HNSCC who had undergone neck dissection with or without primary surgery. Grossing of all surgical specimens was done by guidelines under the College of American Pathologists (November 2021). LNY with their association with other clinic-pathological parameters were analyzed using SPSS software version 21.0.

Results:
A total of 2692 lymph nodes yielded from 112 samples of neck dissection with the mean LNY of 24.02 ± 9.69. A total of 192 lymph nodes were found to be positive with the mean lymph node ratio of 0.07 ± 2.96. Modified radical neck dissection versus selective node dissection performed cases, poor differentiation of tumor, higher tumor stage, more tumor thickness, and positive nodes for metastasis of squamous cell carcinoma were factors that contributed to higher mean LNY over 24.

Conclusions:
In an Indian setting, the mean LNY for HNSCC patients undergoing lymph node dissection is 24.02 and the factors such as node positivity, tumor differentiation, tumor stage, and higher tumor thickness affect the estimation of LNY.
An Investigator-Initiated Study of Gemcitabine and Capecitabine in Indian Patients with Unresectable or Metastatic Gallbladder Cancer
Authors: Palsaniya Sudhir , Saini S. K. , Samar Aseem , Patni Sanjeev , Bapna Ajay 
Published: August 2022

Abstract

Background:
Gallbladder cancer (GBC) has a high incidence rate in the Indo-Gangetic belt and is usually presented in the unresectable advanced or metastatic stage. In this study, we evaluated the response rate and toxicities of the gemcitabine plus capecitabine (GEM-CAP)-based combination chemotherapy in unresectable or metastatic GBC patients.

Subjects and Methods:
This was an investigator-initiated, single-arm, prospective study conducted on unresectable or metastatic GBC patients at Jaipur, India, for 1 year. All the patients received a GEM-CAP combination chemotherapy regimen which consisted of gemcitabine 1000 mg/m2 intravenously over 30 min on days 1 and 8 and capecitabine at 800 mg/m2 orally twice a day for 14 days, administered every 21 days. The response was evaluated in terms of overall response rate (ORR), tumor control rate (TCR), and progression-free survival (PFS). Both quantitative and qualitative toxicities were assessed.

Results:
A total of 35 patients were enrolled, of which 3 patients were excluded due to treatment interruption. The mean age of patients was 55 (32–80) years, with the majority being female (77.14%), having an ECOG score of 1 (71.43%), and with Stage IVB disease (77.14%). The ORR was 25%, TCR was 50%, and median PFS was 4 months. Major toxicities noted were Grade I and II hematological and nonhematological toxicities, which were managed adequately.

Conclusion:
The combination therapy of gemcitabine and capecitabine is reasonable, feasible, and well-tolerated approach for the treatment of unresectable advanced and metastatic GBC patients, a disease that had limited treatment options.
Pengaruh Persepsi Harga, Lokasi dan Kualitas Produk terhadap Keputusan Pembelian di Persebaya Store Komplek
Authors: Sholichah Ika Putri , Sutopo Sutopo , Iman Nurul 
Published: August 2022

Penelitian ini bertujuan untuk mengetahui pengaruh dari persepsi harga, lokasi dan kualitas produk terhadap keputusan pembelian di persebaya store komplek. Metode yang digunakan menggunakan metode deskriptif kuantitatif. Dengan responden sebanyak 100. Hasil penelitian ini Persepsi Harga, Lokasi dan Kualitas Produk secara simultan berkontribusi berpengaruh signifikan terhadap Keputusan Pembelian Persebaya Store Komplek. Persepsi Harga, Lokasi dan Kualitas Produk secara parsial berkontribusi berpengaruh signifikan terhadap Keputusan Pembelian Persebaya Store Komplek. Kualitas Produk yang memiliki pengaruh dominan terhadap Keputusan Pembelian Persebaya Store Komplek.
PENINGKATAN PEMANFAATAN SAMPAH ORGANIK BERBASIS MAHASISWA KREATIF
Authors: Panjaitan Jelita , Hulu Keristiani , Gee Chelvianis , Buulolo Torozatulo 
Published: August 2022

Penelitian terhadap sampah organik bertujuan buat memberikan model pada semua mahasiswa FKIP UDA, awal peningkatan pemanfaatan sampah berbasis kreatif yaitu membuat suatu kerajinan atau wangsit kreatif pada mengelola kembali sampah yang dapat dikembangkan menjadi kapital ilmu dalam berwirausaha. Tujuannya untuk meminimalkan resiko sampah organik, sebab sampah ornganik dapat menyebabkan pencemaran tanah dan udara pula menimbulkan bau tidak sedap berasal sampah yang bertumpuk yang dapat mengakibatkan kesehatan terganggu. Pelaksanaan aktivitas memakai metode observasi, praktikum serta dokumentasi. Metode praktikum dilaksanakan oleh tim di waktu pembuatan hiasan dinding serta daerah pensil yang terbuat asal stik es krim serta kertas bekas, lalu metode dokumentasi dilaksanakan pada ketika observasi serta praktikum menjadi bukti penelitian dilakukan menggunakan baik. target dalam studi ini ialah menaikkan kepedulian mahasiswa terhadap lingkungan fakultas, bagi mitra, kegiatan ini adalah wadah buat mengembangkan ilham- wangsit kreatif dibidang daur ulang sampah organik serta membentuk produk usaha yang bisa dibawa kepasar. Hasil dari pengelolaan sampah organik menjadi sesuatu yang berguna yang di daur ulang yaitu dari sampah stik es krim dan kertas bekas menjadi sebuah tempat pensil dan hiasan dinding sederhana, dimana yang awalnya merupakan sampah yang sudah tidak dibutuhkan lagi dan dengan proses yang cukup detail maka sampah organik tersebut telah di olah menjadi suatu karya sederhana hasilnya unik yaitu tempat pensil dan hiasan dinding.
Entrepreneurial orientation and market orientation as drivers of Micro Small Medium Entrepises (MSMEs') Performance
Authors: Barinta Dunga Dwi , Siti Aisjah  , Christin Susilowati  
Published: August 2022

Micro, Small and Medium Enterprises (MSMEs) contribute to the Gross National Income (GDP) up to 40% and the creation of new job vacancies. Based on 25% of the total number of MSMEs in Indonesia cannot produce during the pandemic. In addition, internal problems such as lack of business knowledge, IT updates, low understanding in market make most MSMEs have low firm performance. Firm performance is an important part of a company to observe and evaluate the suitability of the results in business activities with the predetermined plan. Some researchers believe that firm performance is affected by Entrepreneurial Orientation and Market Orientation. This research was conducted by MSMEs that run their businesses in Malang City, East Java Indonesia. Data collection uses non-probability method approach with simple random sampling technique. The number of respondents collected in this study amounted to 112 respondents, but which can be used in data processing was amounted to 101 respondents. The method of data analysis uses SEM (Structural Equation Modeling) based on Partial Least Square (PLS) using SmartPLS 3.3 software application. This study aims to investigate the role of Entrepreneurial Orientation and Market Orientation in improving the performance of MSMEs. The research findings that entrepreneur orientation and market orientation are proven to have an effect on improving the performance of MSMEs. However, entrepreneur orientation cannot have a direct impact on improving performance. Entrepreneur orientation must be supported by market orientation in improving MSME performance
Faktor yang Mempengaruhi Keputusan Pembelian Produk Fashion di Shopee
Authors: Liana Vega , M.Nawawi Zuhrinal 
Published: August 2022

Advances in technology have resulted in various developments in the corporate sector. Many companies now offer their goods through web applications. Shopee is one of the most popular online retail business applications today. The aims of this study were to: 1) determine the effect of product, price, promotion, distribution, people, process, and the physical environment on purchasing decisions for fashion products at Shopee, and 2) determine the effect of product, price, promotion, distribution, people, process. , and the physical environment for purchasing decisions for fashion products at Shopee for UINSU Medan students. The approach is quantitative. The participants in this study were UINSU Medan students who had used the Shopee application to shop for fashion items. The findings of this study indicate that product, price, promotion, distribution, people, process, and physical environment variables all influence the purchasing decision of fashion products at Shopee, and that product, price, promotion, distribution, people, process, and physical environment variables are all influence the purchasing decisions of fashion products at Shopee. greatly influenced the decision of UINSU Medan students to shop for fashion at Shopee.
Keywords:Online Purchase Factor, Online Purchase Decision, Purchase Decision
Pengaruh Faktor Lingkungan Keluarga terhadap Minat Berwirausaha
Authors: Monica Aulia , M. Nawawi Zuhrinal 
Published: August 2022

Interest in entrepreneurship is the desire, interest, and willingness of individuals to work hard in fulfilling their life needs without fear of the risks that will occur. The analysis used in this observation is descriptive qualitative, with a literature review methodology that uses several sources such as journals as the main reference for conducting research. The results obtained. Interest in entrepreneurship will arise if someone has gained a lot of knowledge horizons about entrepreneurship either from the experience of others or from the experience of others. entrepreneurship book. Someone who is already interested and interested in becoming an entrepreneur will be more familiar with activities related to entrepreneurship. knowing about entrepreneurial activities. It can be concluded that the environment is very influential and supportive for entrepreneurship, then the interest in entrepreneurship will be even greater. Family environment has a positive effect on Entrepreneurial Interest.
Keywords: environment, family, entrepreneur
Faktor-Faktor yang Mempengaruhi Partisipasi Masyarakat terhadap Minat Dalam Program Desa Sadar Jaminan Sosial Ketenagakerjaan pada Desa Amplas Kecamatan Percut Sei Tuan Kabupaten Deli Serdang
Authors: Lubis Nur Hayati , Nasution Yenni Samri Juliati , Nasution Annio Indah Lestari 
Published: August 2022

.Employment social security is an innovative program that is given to the community in the village, integrating government programs. Cooperation with government officials through socialization and education to the working community in the village to better understand the benefits of the importance of social security. This study aims to determine the factors that influence the participation of the sandpaper village community towards interest in the employment social security awareness village program and the researchers took two factors, namely awareness and knowledge. The researcher wants to see the effect of awareness and knowledge on interest in the employment social security Desa Sadar program in Amplas Village, either partially or simultaneously. The method used in this research is quantitative. The population of this study was 2,625 people, so by using the Slovin formula the author got the number 96 which will be the sample in this study. Using primary data by distributing questionnaires and also distributing questionnaires directly to the Amplas Village community. Using multiple regression analysis method using hypothesis testing. The results of this study simultaneously from the variable awareness of knowledge and knowledge have a significant effect on interest in the social security awareness village program for employment. Then partially the awareness variable has no effect on interest and the knowledge variable itself has a significant effect on interest in the employment social security awareness village program.
Keywords : Awareness, Interests, Knowledge and Desa Sadar Programs