bluuebunny/crossref_metadata_2025_split huggingface dataset:
Early detection of anthracycline‐ and trastuzumab‐induced cardiotoxicity: value and optimal timing of serum biomarkers and echocardiographic parameters
Authors: Díaz‐Antón Belén , Madurga Rodrigo , Zorita Blanca , Wasniewski Samantha , Moreno‐Arciniegas Andrea , López‐Melgar Beatriz , Ramírez Merino Natalia , Martín‐Asenjo Roberto , Barrio Patricia , Amado Escañuela Maximiliano German , Solís Jorge , Parra Jiménez Francisco Javier , Ciruelos Eva , Castellano José María , Fernández‐Friera Leticia 
Published: February 2022

AbstractAimsTo evaluate echocardiographic and biomarker changes during chemotherapy, assess their ability to early detect and predict cardiotoxicity and to define the best time for their evaluation.Methods and resultsSeventy‐two women with breast cancer (52 ± 9.8 years) treated with anthracyclines (26 also with trastuzumab), were evaluated for 14 months (6 echocardiograms/12 laboratory tests). We analysed: high‐sensitivity cardiac troponin T, NT‐proBNP, global longitudinal strain (GLS), left ventricle end‐systolic volume (LVESV), left ventricle end‐diastolic volume (LVEDV), and left ventricular ejection fraction (LVEF). Cardiotoxicity was defined as a reduction in LVEF>10% compared with baseline with LVEF<53%. High‐sensitivity troponin T levels rose gradually reaching a maximum peak at 96 ± 13 days after starting chemotherapy (P < 0.001) and 62.5% of patients presented increased values during treatment. NT‐proBNP augmented after each anthracycline cycle (mean pre‐cycle levels of 72 ± 68 pg/mL and post‐cycle levels of 260 ± 187 pg/mL; P < 0.0001). Cardiotoxicity was detected in 9.7% of patients (mean onset at 5.2 months). In the group with cardiotoxicity, the LVESV was higher compared with those without cardiotoxicity (40 mL vs. 29.5 mL; P = 0.045) at 1 month post‐anthracycline treatment and the decline in GLS was more pronounced (−17.6% vs. −21.4%; P = 0.03). Trastuzumab did not alter serum biomarkers, but it was associated with an increase in LVESV and LVEDV (P < 0.05). While baseline LVEF was an independent predictor of later cardiotoxicity (P = 0.039), LVESV and GLS resulted to be early detectors of cardiotoxicity [odds ratio = 1.12 (1.02–1.24), odds ratio = 0.66 (0.44–0.92), P < 0.05] at 1 month post‐anthracycline treatment. Neither high‐sensitivity troponin T nor NT‐proBNP was capable of predicting subsequent cardiotoxicity.ConclusionsOne month after completion of anthracycline treatment is the optimal time to detect cardiotoxicity by means of imaging parameters (LVESV and GSL) and to determine maximal troponin rise. Baseline LVEF was a predictor of later cardiotoxicity. Trastuzumab therapy does not affect troponin values hence imaging techniques are recommended to detect trastuzumab‐induced cardiotoxicity.
Isotopic signature of a glacial influenced hydrological system in northern Patagonia, Argentina
Authors: Sepúlveda Laura Daniela , Echegoyen Cecilia Vanina , Martin Maria Eugenia , Campodonico Verena Agustina , Pasquini Andrea Inés , Temporetti Pedro , Lecomte Karina Leticia 
Published: February 2022

AbstractHigh glacial mountain environments around the world are important water reservoirs and are extremely sensitive to the effects of climate change. Considering that climate change affects snow accumulation and glacial melting, it is essential to understand the runoff generation and hydrological dynamics in these type of systems. Andean glaciers have shown a retreating and thinning pattern since the start of the 21st century. Regarding this, the stable isotopic composition of waters is useful to assess the contributions from different sources (i.e., glaciers, precipitation, and tributaries' inputs) to rivers. Several Patagonian mountain rivers have Andean glaciers in their headwaters, one of which is the Manso River. In this basin, over the last 30 years, the Ventisquero Negro Glacier (Manso Glacier's regenerated tongue) experienced a rapid thinning and recession that generated a proglacial lake, called Manso proglacial Lake. In this study, topographic effects upon the stable isotopic composition of river waters (δ2H and δ18O) are recognized, particularly, the altitude effect. The stable isotope composition of the Manso River varies downstream, evolving to a composition more enriched in heavy isotopes in the lower basin, likely due to altitude effects and the progressive evaporation that mainly occurs in the lakes' surfaces that the river crosses. Results show that glacial meltwater is the major water contributor in the upper basin during early fall. In the rest of the basin the stable isotopic composition of the Manso River is mainly controlled by the lakes' isotopic signatures and is highly influenced by two tributary rivers. The concordance between isotopic models and hydrological data demonstrates that stable isotopes constitute a valuable tool to quantify the contribution of different water sources. This has the potential to be particularly useful in areas where discharge data is unavailable.
Groundwater‐surface water exchange as key control for instream and groundwater nitrate concentrations along a first‐order agricultural stream
Authors: Jimenez‐Fernandez Oscar , Schwientek Marc , Osenbrück Karsten , Glaser Clarissa , Schmidt Christian , Fleckenstein Jan H. 
Published: February 2022

AbstractLower‐order streams (first‐ and second‐order) define the initial, landscape‐related, chemical signature of stream water in catchments. To date, first‐order streams have been perceived as predominantly draining systems, which collect water and solutes from the surrounding groundwater and surface runoff and simply mirror the chemical composition of the inputs. In this study, the impact of stream‐groundwater exchange fluxes on water chemistry of a first order agricultural stream (Schönbrunnen) and its connected groundwater in south‐western Germany was assessed combining222Rn, dissolved ions (chloride, sulphate, nitrate), and salt tracer tests with investigations of stream discharge and groundwater hydraulic gradients. The findings suggest that stream‐water chemistry in lower‐order streams is governed by an intricate interplay between dynamic, bidirectional water and solute exchange between groundwater and the stream leading to a pronounced hydrologic turnover along the studied reaches. High nitrate concentrations (up to 79 mg/L as NO3−) in stream water were attenuated in downstream direction (a mean value of 39 mg/L) without an increase in discharge, suggesting that redox processes occurring during sediment passage in sequential infiltration and exfiltration zones affect stream water chemistry. Nitrate in stream water infiltrating into the aquifer at distinct losing spots was subject to denitrification within the first few decimetres of the streambed, while concurrent exfiltration of low‐nitrate groundwater into the stream at gaining spots compensated for flow losses and in turn diluted instream nitrate concentrations. In summary the findings imply that (1) instream mixing resulting from the bidirectional exchange of water between groundwater and the stream (hydrologic turnover) affects instream nitrate concentrations, (2) denitrification in the streambed of losing reaches and the near‐stream aquifer significantly contributes to reactive nitrate turnover and elimination, and (3) oxidation of ammonium could be a secondary source of nitrate inputs into the stream.
Block‐transitive automorphism groups of 2‐(v,k,λ) $(v,k,\lambda )$ designs with (r,k)=1 $(r,k)=1$
Authors: Zhang Wanbao , Zhou Shenglin 
Published: February 2022

AbstractIn 1984, Camina and Gagen gave the result that the block‐transitive automorphism group of a 2‐ design with must be flag‐transitive, moreover, is point‐primitive of affine or almost simple type. As a generalization of this result, the purpose of this paper is to study block‐transitive automorphism groups of nontrivial 2‐ designs with , where is the number of blocks incident with a given point. We prove that, for a 2‐ design with , if is block‐transitive, then must be flag‐transitive, and furthermore, is point‐primitive of affine or almost simple type. Moreover, the classification of this type of 2‐designs is given when the socle of is sporadic. There are thirteen 2‐designs up to isomorphism.
Circ_0072088 knockdown contributes to cisplatin sensitivity and inhibits tumor progression by miR‐944/LASP1 axis in non‐small cell lung cancer
Authors: Zhang Lei , Wu Yuanzhou , Hou Chunyang , Li Fangzhi 
Published: February 2022

AbstractBackgroundNon‐small cell lung cancer (NSCLC) is an aggressive tumor that accounts for a large proportion of cancer‐related deaths. Cisplatin (CDDP) has been utilized to treat NSCLC. However, the efficacy of CDDP is usually restrained owing to the development of drug resistance. This study aims to reveal the molecular mechanism of the resistance of NSCLC cells to CDDP.MethodsThe expression levels of circRNA_0072088 (circ_0072088), microRNA‐944 (miR‐944), and LIM and SH3 protein 1 (LASP1) were measured by quantitative real‐time PCR (qRT‐PCR) in CDDP‐resistant NSCLC tissues and cells. Protein expression was determined by Western blotting in CDDP‐resistant NSCLC tissues and cells. The functional effects of circ_0072088, miR‐944, and LASP1 on CDDP sensitivity and NSCLC progression were revealed by Cell Counting Kit‐8 (CCK‐8), flow cytometry, cell colony formation, wound healing, and transwell invasion assays. The binding relationship between miR‐944 and circ_0072088 or LASP1 was identified by a dual‐luciferase reporter and RNA immunoprecipitation assay. The effects of circ_0072088 knockdown on tumor growth in vivo were analyzed by an in vivo tumor formation assay.ResultsCirc_0072088 and LASP1 expression were significantly upregulated, while miR‐944 expression was downregulated in CDDP‐resistant NSCLC tissues and cells as compared with control groups. Circ_0072088 expression was significantly associated with tumor–node–metastasis stage and tumor size. Functionally, circ_0072088 knockdown improved CDDP sensitivity and repressed NSCLC cell malignancy, whereas miR‐944 inhibitor hindered these effects. Mechanistically, circ_0072088 functioned as a sponge for miR‐944 and miR‐944 targeted LASP1. Circ_0072088 knockdown improved the sensitivity of tumor to CDDP in vivo.ConclusionCirc_0072088 silencing improved CDDP sensitivity and inhibited NSCLC progression by downregulating LASP1 expression through sponging miR‐944. These data provide novel insight into the resistance of NSCLC to CDDP.
Immunogenicity and safety of the BNT162b2 COVID‐19 mRNA vaccine in PLWH: A monocentric study in Bari, Italy
Authors: Milano Eugenio , Ricciardi Aurelia , Casciaro Raffaella , Pallara Elisabetta , De Vita Elda , Bavaro Davide F. , Larocca Angela Maria Vittoria , Stefanizzi Pasquale , Tafuri Silvio , Saracino Annalisa 
Published: February 2022

AbstractIn March, people living with HIV infection (PLWH) were included in the risk category of fragile people for severe COVID‐19 receiving priority access to vaccination with BNT162b2 vaccine. The aim of the study was to evaluate the immunogenicity and safety of the two doses regimen. The antibodies titer for severe acute respiratory syndrome‐related coronavirus‐2 (SARS‐CoV‐2) was evaluated after 21 days since the first administration (Time 1), 1 (Time 2), and 3 (Time 3) months post‐vaccination. Information regarding virological and immunological conditions at baseline, previous SARS‐CoV‐2 state of infection, other immunodeficiencies, current antiretroviral therapy (ART), comorbidities, and severe adverse events (SAE) to vaccination was collected. Six hundred and ninety‐seven patients were tested for quantitative anti‐spike antibodies at Time 1, 577 patients had a second detection at Time 2, and 491 patients had the third detection. Baseline characteristics of the study population are reported in Table 1. At the time of vaccine administration, all patients were on ART (except one long‐term nonprogressor); 632 (90.7%) patients had undetectable HIV‐RNA; 12 (1.7%) patients were immunosuppressed due to chemotherapy or other immunosuppressive drugs; 345 (49.5%) patients had at least one COVID‐19 related comorbidity and 155 (22.2%) had two or more comorbidities. No SAEs were reported. Final serological results are available for 694 patients after the first dose, 577 and 491 after the second and third ones, respectively; positive titer (values ≥ 50 AU/ml) was demonstrated in 653 (94.1%), 576 (99.8%), 484 (98.6%) patients, respectively. Only one patient was a nonresponder after completing vaccination, who was a newly diagnosed one for HIV infection. All vaccinations were well tolerated, with no SAEs. BNT162b2 mRNA vaccine was immunogenic and safe in PLWH.
Development of a wind and Pasquill stability class climate dataset for the North American Great Lakes region
Authors: Kiefer Michael T. , Andresen Jeffrey A. , Rozeboom Dale W. , Bian Xindi 
Published: February 2022

AbstractIn this study, a North American Regional Reanalysis (NARR)‐based climate dataset of wind and Pasquill stability class is developed for the North American Great Lakes region. Motivated by the need to update the limited wind and Pasquill stability class climatology previously incorporated into a livestock odour nuisance‐mitigation application used in Michigan, this study is motivated more generally by the lack of a long‐term climate dataset suitable for studies of atmospheric dispersion in the Great Lakes region. As a preliminary step, NARR 10‐m wind speed, 10‐m wind direction, and 2‐m temperature are evaluated at eight weather stations in Michigan and northern Indiana, and the wind speed variable is subsequently bias‐corrected. To derive a Pasquill stability class dataset from the NARR variables, an existing empirical relationship between Pasquill stability class and Richardson number is applied to a previously developed NARR‐derived Richardson number dataset covering the period 1979–2008. Pasquill stability class frequency in NARR is subsequently evaluated using observations at two flux towers in Illinois. Although a tendency is noted for the NARR‐derived Pasquill stability class dataset to underestimate the frequency of stable and unstable conditions, and overestimate the frequency of neutral conditions, the analysis shows that the 10‐m wind speed bias‐correction procedure yields a frequency distribution that is in better agreement with the observations than the non‐bias‐corrected dataset. Finally, an analysis of the spatial and temporal variability of livestock odour dispersion potential in Michigan is provided as an example application of the NARR‐based wind and Pasquill stability class climate dataset.
Comparing the performance of high‐resolution global precipitation products across topographic and climatic gradients of Central Asia
Authors: Peña‐Guerrero Mayra Daniela , Umirbekov Atabek , Tarasova Larisa , Müller Daniel 
Published: February 2022

AbstractAccurate and reliable precipitation data with high spatial and temporal resolution are essential in studying climate variability, water resources management, and hydrological forecasting. A range of global precipitation data are available to this end, but how well these capture actual precipitation remains unknown, particularly for mountain regions where ground stations are sparse. We examined the performance of three global high‐resolution precipitation products for capturing precipitation over Central Asia, a hotspot of climate change, where reliable precipitation data are particularly scarce. Specifically, we evaluated MSWEP, CHIRPS, and GSMAP against independent gauging stations for the period 1985–2015. Our results show that MSWEP and CHIRPS outperformed GSMAP for wetter periods (i.e., winter and spring) and wetter locations (150–600 mm·year−1), lowlands, and mid‐altitudes (0–3,000 m), and regions dominated by winter and spring precipitation. MSWEP performed best in representing temporal precipitation dynamics and CHIRPS excelled in capturing the volume and distribution of precipitation. All precipitation products poorly estimated precipitation at higher elevations (>3,000 m), in drier areas (<150 mm), and in regions characterized by summer precipitation. All products accurately detected dry spells, but their performance decreased for wet spells with increasing precipitation intensity. In sum, we find that CHIRPS and MSWEP provide the most reliable high‐resolution precipitation estimates for Central Asia. However, the high spatial and temporal heterogeneity of the performance call for a careful selection of a suitable product for local applications considering the prevailing precipitation dynamics, climatic, and topographic conditions.
Spatial patterns of atmospheric vapour transport and their connection to drought in New Zealand
Authors: Bennet Morgan J. , Kingston Daniel G. 
Published: February 2022

AbstractThe impacts of drought can be substantial, particularly for primary producing nations such as New Zealand. Despite the importance of drought, identifying connections to atmospheric drivers remains a challenge. Vertically integrated water vapour transport (IVT) is critical to understanding the connection between ocean, atmosphere and the land surface, and as such the drivers of drought events. Self‐organizing maps (SOMs) are used here to characterize the spatial patterns of IVT over New Zealand. In turn, the occurrence of these patterns during drought conditions (defined using the standardized precipitation and evapotranspiration index) across New Zealand is then identified and discussed. The resulting classification highlights a collection of high and low IVT magnitude nodes (i.e., spatial patterns). Low IVT nodes occur 40.57% of the time during all drought events and 45.86% during the top 99th percentile events. Conversely, high IVT magnitude nodes occur less frequently during drought events, at 23.77 and 20.96% of the time during all drought events and the top 99th percentile events, respectively. The low IVT nodes are also particularly dominant during summer and autumn season drought events. An increase in the frequency of occurrence of drought‐associated nodes is observed over the course of the study period, which may in part be associated with El Niño–Southern Oscillation (ENSO)‐driven interannual variability in New Zealand climate. Overall, the results demonstrate the importance of atmospheric circulation‐driven disruptions in moisture transport for drought development, while also providing a first moisture transport weather classification for New Zealand.
Lifestyle entrepreneurship innovation and self‐efficacy: Exploring the direct and indirect effects of marshaling
Authors: Dias Álvaro , Cascais Eduardo , Pereira Leandro , Lopes da Costa Renato , Gonçalves Rui 
Published: February 2022

AbstractLifestyle entrepreneurs play a key role in the destination sustainable development by providing more authentic and innovative experiences. However, the determinants of the innovation generated by these entrepreneurs are not fully understood. This study explores the key factors influencing innovation and entrepreneurial self‐efficacy (ESE) in lifestyle entrepreneurs. Survey data allowed to identify the effect of marshaling, place familiarity, and communication on innovation and ESE. Findings reveal several direct and indirect relationships between these variables. The results indicate that marshaling has a significantly positive and direct effect on both ESE and communication. Communication has a direct and positive relationship with innovation. Place familiarity perception has a significantly positive and direct relation to communication and innovation on ESE. It was also found an indirect link between marshaling and innovation via communication as a mediator.
Effects of liner surface textures on the tribological performance of different production piston rings
Authors: Xu Bo , Yin Bifeng , Jia Hekun , Hua Xijun , Wei Mingliang 
Published: February 2022

AbstractBased on the characteristics of engine working conditions, the ring/liner reciprocating friction tests were conducted to research the effects of three typical cylinder liner surface topographies (honed surface, large dimple texture and small dimple texture) on the tribological performance of production piston ring pack. The experimental results demonstrated the effects of liner textures are different between three kinds of piston rings: for the barrel‐shaped ring‐liner pair, the large or small dimple texture has its specific working condition; for the taper‐faced ring‐liner pair, the oil scraping efficiency and oil distributing stability can be improved by texturing small dimples on liner surface; while the dimple textures have little influence on the friction force of oil control ring‐liner pair. In addition, texturing micro‐dimples on liner is conducive to reducing the surface wear caused by abrasive wear, and the anti‐wear effect of small dimple texture is much better.
Transcriptional activation of S100A2 expression by HIF‐1α via binding to the hypomethylated hypoxia response elements in HCC cells
Authors: Yan Jia , Huang Ya Jun , Huang Qing Yu , Liu Peng Xia , Wang Chang Shan 
Published: February 2022

AbstractHepatocellular carcinoma (HCC) is one of the most prevalent and lethal cancers. Dysregulation of S100A2 has recently been found in many cancers including HCC. However, its regulatory mechanism in HCC remains poorly understood, especially in hypoxia. In this study, we found that S100A2 is upregulated and correlated with the clinicopathological features of HCC patients. Moreover, the elevated S100A2 showed worse overall survival. Functionally, S100A2 inhibition decreased the proliferation and migration of HepG2 cells. Interestingly, we found that HIF‐1α directly binds to hypoxia response elements (HREs) of the S100A2 promoter region. S100A2 expression could be induced in an HIF‐1α‐dependent manner under hypoxia. Furthermore, S100A2 silencing significantly suppressed HCC cell proliferation and invasion under hypoxia. Mechanistically, pyrosequencing results showed that the hypomethylation status of CpG located in the HRE at the S100A2 promoter was correlated with S100A2 induction. Additionally, HIF‐1α‐ mediated S100A2 activation was associated with TET2‐related epigenetic inactivation. TET2 was enriched in the HRE of the S100A2 promoter in HepG2 cells. Finally, S100A2 methylation‐related genes and pathways were analyzed. We found that the methylation of S100A2 is correlated with ANXA2, PPP1R15A, and FOS, which include in a hypoxia‐related gene set from the GSEA database. Moreover, some EMT‐related genes are associated with the methylation of S100A2 in HCC. Conclusively, our study thus uncovered a novel mechanism showing that hypoxia/HIF‐1α signaling associated with DNA methylation enhances S100A2 expression in HCC. S100A2 may be useful as a target for facilitating novel diagnostic and therapeutic strategies in liver cancer.