bluuebunny/crossref_metadata_2025_split huggingface dataset:
Undiagnosed prediabetes in Mexican adolescents under poverty in contexts affected by collective violence: A clinical comparison among health services users and hidden population
Authors: Hernández-Montoya Dewi , Cedillo-Escobar Elsie E. , Esparza-Aguilar Marcelino , Muñoz-Torres Abril Violeta 
Published: November 2022

IntroductionThe epidemiological pattern of prediabetes in adolescents is understudied. In Mexico, adolescents are exposed to social adversity conditions, including poverty and violence. Therefore, understanding their clinical profiles and how the social determinants of health impose barriers to access to health services is important to address detection, in those who, by their vulnerability, remain a hidden population.AimThis study aimed to describe undiagnosed prediabetes in Mexican adolescents under poverty in violent contexts and to compare the clinical features among health services users and hidden population.MethodsThis cross-sectional study included 371 adolescents from difficult access locations in violent contexts. Poverty, lack of health services access, and perceived vulnerability were determined in all samples. Endocrine markers (BMI, HOMA-IR, HbA1c, and cortisol) were measured in those with high violence perception.ResultsA total of 61.7% of the adolescents had a suburban grid and urban cluster residence, and 77.7–85.7% of them belonged to locations where 35–50% of their population lived below the poverty line. In total, 40–75% had a lack of 10–20% access to health services, and 18.8% had a high perceived vulnerability due to collective violence and were screened. Overall, 61.9% of respondents were newly diagnosed with prediabetes and showed the worst HbA1c (p = 0.001) compared to the health services subsample, which showed the highest BMI (p = 0.031) and insulin resistance (p = 0.025).ConclusionThere is a prediabetes hidden population living in violent contexts under poverty. These social determinants promote poor outcomes in perceived vulnerability and endocrine response and represent barriers to access to health services.
Using a classification model for determining the value of liver radiological reports of patients with colorectal cancer
Authors: Liu Wenjuan , Zhang Xi , Lv Han , Li Jia , Liu Yawen , Yang Zhenghan , Weng Xutao , Lin Yucong , Song Hong , Wang Zhenchang 
Published: November 2022

BackgroundMedical imaging is critical in clinical practice, and high value radiological reports can positively assist clinicians. However, there is a lack of methods for determining the value of reports.ObjectiveThe purpose of this study was to establish an ensemble learning classification model using natural language processing (NLP) applied to the Chinese free text of radiological reports to determine their value for liver lesion detection in patients with colorectal cancer (CRC).MethodsRadiological reports of upper abdominal computed tomography (CT) and magnetic resonance imaging (MRI) were divided into five categories according to the results of liver lesion detection in patients with CRC. The NLP methods including word segmentation, stop word removal, and n-gram language model establishment were applied for each dataset. Then, a word-bag model was built, high-frequency words were selected as features, and an ensemble learning classification model was constructed. Several machine learning methods were applied, including logistic regression (LR), random forest (RF), and so on. We compared the accuracy between priori choosing pertinent word strings and our machine language methodologies.ResultsThe dataset of 2790 patients included CT without contrast (10.2%), CT with/without contrast (73.3%), MRI without contrast (1.8%), and MRI with/without contrast (14.6%). The ensemble learning classification model determined the value of reports effectively, reaching 95.91% in the CT with/without contrast dataset using XGBoost. The logistic regression, random forest, and support vector machine also achieved good classification accuracy, reaching 95.89%, 95.04%, and 95.00% respectively. The results of XGBoost were visualized using a confusion matrix. The numbers of errors in categories I, II and V were very small. ELI5 was used to select important words for each category. Words such as “no abnormality”, “suggest”, “fatty liver”, and “transfer” showed a relatively large degree of positive correlation with classification accuracy. The accuracy based on string pattern search method model was lower than that of machine learning.ConclusionsThe learning classification model based on NLP was an effective tool for determining the value of radiological reports focused on liver lesions. The study made it possible to analyze the value of medical imaging examinations on a large scale.
Dynamic alterations in PD-1/PD-L1 expression level and immune cell profiles based on radiation response status in mouse tumor model
Authors: Yoon Yi Na , Choe Min Ho , Kong Moonkyoo , Chung Weon Kuu , Kim Jae-Sung , Lim Yu Jin 
Published: November 2022

IntroductionBased on the immunologic effects of anti-cancer treatment and their therapeutic implications, we evaluated radiotherapy (RT)-induced dynamic alterations in programmed death-1 (PD-1)/PD ligand-1 (PD-L1) expression profiles.MethodsLocal RT with 2 Gy × 5 or 7.5 Gy × 1 was administered to the CT26 mouse model. Thereafter, tumors were resected and evaluated at the following predefined timepoints according to radiation response status: baseline, early (immediately after RT), middle (beginning of tumor shrinkage), late (stable status with RT effect), and progression (tumor regrowth). PD-1/PD-L1 activity and related immune cell profiles were quantitatively assessed.ResultsRT upregulated PD-L1 expression in tumor cells from the middle to late phase; however, the levels subsequently decreased to levels comparable to baseline in the progression phase. RT with 2 Gy × 5 induced a higher frequency of PD-L1+ myeloid-derived suppressor cells, with a lesser degree of tumor regression, compared to 7.5 Gy. The proportion of PD-1+ and interferon (IFN)-γ+CD8α T cells continued to increase. The frequency of splenic PD-1+CD8+ T cells was markedly elevated, and was sustained longer with 2 Gy × 5. Based on the transcriptomic data, RT stimulated the transcription of immune-related genes, leading to sequentially altered patterns.DiscussionThe dynamic alterations in PD-1/PD-L1 expression level were observed according to the time phases of tumor regression. This study suggests the influence of tumor cell killing and radiation dosing strategy on the tumor immune microenvironment.
Prognostic and predictive value of YTHDF1 and YTHDF2 and their correlation with tumor-infiltrating immune cells in non-small cell carcinoma
Authors: Koh Young Wha , Han Jae-Ho , Haam Seokjin , Lee Hyun Woo 
Published: November 2022

BackgroundYTH domain-containing family protein 1 (YTHDF1) or YTHDF2 play crucial roles in cancer immunotherapy. We examine the expression of YTHDF1, YTHDF2, CD8, CD4, and FOXP3 to identify their prognostic or predictive role for PD-1/PD-L1 inhibitor in non-small cell lung cancer (NSCLC).MethodsImmunohistochemical expression of YTHDF1, YTHDF2, CD8, CD4, and FOXP3 was investigated in 266 patients not receiving PD-1/PD-L1 inhibitors and in 59 patients receiving PD-1/PD-L1 inhibitors. Immunohistochemical results were verified using mRNA dataset obtained from The Cancer Genome Atlas (TCGA) database.ResultsImmunohistochemical expression of YTHDF1 or YTHDF2 was negatively associated with CD8- and CD4-positive T cells; however, the same expression was positively associated with FOXP3-positive T cells. YTHDF1 or YTHDF2 mRNA expression was also negatively associated with CD8- and CD4-positive T cells. Gene set enrichment analysis revealed that low YTHDF1 was related to immune hot tumor gene sets. Expression of YTHDF1 or YTHDF2 was negatively associated with expression of most immune checkpoints. YTHDF1 and YTHDF2 were predictive markers of response to PD-1/PD-L1 inhibitors. YTHDF1 or YTHDF2 expression was associated with better prognosis. YTHDF1 has an immune hot profile in both cell types, whereas YTHDF2 is only seen in adenocarcinoma.ConclusionLow YTHDF1 or YTHDF2 reflects an immune hot tumor signature and may serve as a predictor or prognostic marker.
Prenatal diagnosis and postnatal management of congenital mesoblastic nephroma: A case report and literature review
Authors: Zhang Xiaoxiao , Zhang Huijing , Wang Shuang , Gao Yangxu , Liang Li , Yang Huixia 
Published: November 2022

BackgroundCongenital mesoblastic nephroma (CMN) is a rare renal tumour in children, the most common kidney tumour in the neonatal period. It can be divided into three types, classical, cellular and mixed.Case presentationA 31-year-old Chinese woman had no apparent foetal abnormality in regular prenatal care during the first and second trimesters. At 33 weeks of gestation, a solid mass in the right kidney was noted with echoes similar to liver and hypervascularity. It grew larger during late pregnancy. The infant was transferred to have a radical nephrectomy on the 9th day after birth. The postoperative histopathological result indicated classical CMN.ConclusionCMN could be detected prenatally, mainly during late pregnancy. The postnatal outcome is good.
High-flow nasal cannula versus continuous positive airway pressure in primary respiratory support for preterm infants: A systematic review and meta-analysis
Authors: Luo Keren , Huang Yi , Xiong Tao , Tang Jun 
Published: November 2022

Respiratory support is crucial for the survival of preterm infants, and High-flow Nasal Cannula Oxygen Therapy (HFNC) and Continuous Positive Airway Pressure (CPAP) are commonly used for neonatal respiratory support. This meta-analysis aimed to compare the effects of HFNC and CPAP in primary respiratory support for preterm infants, to provide evidence-based support for clinical practice. PubMed, Embase, Cochrane Library, ClinicalTrials.gov, CNKI, VIP, WANFANG and SinoMed were searched for eligible studies. The primary outcomes included the incidence of treatment failure and the application of mechanical ventilation. A total of 27 eligible studies with 3,351 participants were included. There was no significant difference in the incidence of respiratory support failure [RR = 1.17, 95%CI (0.88–1.56)] and the application of mechanical ventilation [RR = 1.00, 95%CI (0.84–1.19)] between HFNC group and CPAP group. HFNC resulted in lower rate of air leaks [RR = 0.65, 95%CI (0.46–0.92)], nasal trauma [RR = 0.36, 95%CI (0.29–0.45)] and abdominal distension [RR = 0.39, 95%CI (0.27–0.58)], and later time of mechanical ventilation initiating [SMD = 0.60, 95%CI (0.21–0.99)], less duration of oxygen therapy [SMD = −0.35, 95%CI (−0.68 to −0.02)] and earlier enteral feeding [SMD = −0.54, 95%CI (−0.95 to −0.13)]. Alternative non-invasive respiratory support after initial treatment failure resulted in no difference in the application of mechanical ventilation between the two groups [RR = 0.99, 95%CI (0.52–1.88)]. HFNC might be more effective and safer in primary respiratory support for preterm infants. Using CPAP as a remedy for the treatment failure of HFNC could not avoid intubation. For premature infants with the gestational age &lt;28 weeks, HFNC as primary respiratory support still needs to be further elucidated.Systematic Review Registration: https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42022313479, identifier: CRD42022313479.
Genotyping for HLA risk alleles versus patch tests to diagnose anti-seizure medication induced cutaneous adverse drug reactions
Authors: Manson Lisanne E. N. , Chan Patricia C. Y. , Böhringer Stefan , Guchelaar Henk-Jan 
Published: November 2022

Aim: To provide a comparison of genotyping for HLA risk alleles versus patch testing to determine which of these two tests is a better diagnostic tool for cutaneous hypersensitivity reactions caused by anti-seizure medication.Methods: A literature study was performed in PubMed to assess the sensitivity and specificity of HLA genotyping and patch tests for identifying anti-seizure medication induced cutaneous hypersensitivity reactions.Results: This study shows that HLA-B*15:02 genotyping shows high sensitivity for carbamazepine-induced SJS/TEN, especially in Han Chinese and Southeast Asian patients (66.7–100.0%) whereas the sensitivity of patch tests (0.0–62,5%), HLA-A*31:01 (0–50%) and HLA-B*15:11 (18.2–42.9%) are lower. On the contrary, for carbamazepine and phenytoin induced DRESS, patch tests (respectively 70.0–88.9% and 14.3–70.0%) show higher sensitivity than HLA tests (0–66.7% and 0–12.7%). Also for lamotrigine-induced DRESS patch tests perform better than HLA-B*15:02 (33.3–40.0 versus 0%). For anti-seizure medication induced MPE and for oxcarbazepine-induced SCARs more studies are needed.Conclusion: Use of HLA-B genotyping may aid clinicians in the diagnosis of carbamazepine, phenytoin, lamotrigine and oxcarbazepine induced SJS/TEN, particularly in Han Chinese and Southeast Asian patients. On the other hand, patch tests seem to perform better in the diagnosis of carbamazepine and phenytoin induced DRESS.
Prognostic value of inflammatory biomarkers in aged patients with oral squamous cell carcinoma
Authors: Yoshimura Takuya , Suzuki Hajime , Takayama Hirotaka , Higashi Shotaro , Hirano Yuka , Tezuka Masahiro , Ishida Takayuki , Ishihata Kiyohide , Amitani Marie , Amitani Haruka , Nishi Yasuhiro , Nakamura Yasunori , Imamura Yasushi , Nozoe Etsuro , Inui Akio , Nakamura Norifumi 
Published: November 2022

Background: Better prognostic biomarkers for oral squamous cell carcinoma (OSCC) must be developed, particularly within the realm of clinically and frequently administered tests, to advise appropriate clinical therapy and follow-up. In this study, we retrospectively investigated which of the several inflammation-nutrition indicators might predict the prognosis of patients with OSCC.Methods:  The preoperative neutrophil-lymphocyte ratio (NLR), lymphocyte–monocyte ratio (LMR), platelet–lymphocyte ratio (PLR), CRP-albumin ratio (CAR), Glasgow prognostic score (GPS), modified GPS (mGPS), prognostic nutritional index (PNI), controlling nutrition status (CONUT), and modified CONUT (mCONUT) were retrospectively evaluated using blood samples collected 1–5 days before surgery. To estimate the effect on the prognosis of tumor progression, the mean values of the markers between stages I/II and III/IV were used for subgroup analysis. The multivariate Cox proportional hazards model included all independent variables significantly associated with survival in the univariate analysis to determine the independent variables.Results: A total of 112 patients (69 males and 43 females) with primary OSCC who underwent surgical treatment at our hospital were included. There were statistically significant differences in the mean values of monocytes, platelets, and albumin between stages I/II and III/IV. According to the multivariate Cox proportional hazards regression, a low PNI was associated with shorter overall survival (OS) and disease-free survival (DFS); women were associated with shorter DFS.Conclusion: The pretreatment PNI had excellent predictive value for the 5-year OS and DFS of patients with OSCC. Future large-scale prospective studies with a high sample size are needed to verify our findings in OSCC patients.
Analysis of electrical properties in lateral Schottky barrier diode based on n-GaN and AlGaN/GaN heterostructure
Authors: Liu Honghui , Liang Zhiwen , Wang Fengge , Xu Yanyan , Yang Xien , Liang Yisheng , Li Xin , Lin Lizhang , Wu Zhisheng , Liu Yang , Zhang Baijun 
Published: November 2022

In this paper, the lateral Schottky barrier diodes (SBDs) with small capacitance and low turn-on voltage (Von) were fabricated on n-GaN and AlGaN/GaN heterostructure. The capacitances of lateral n-GaN SBD and lateral AlGaN/GaN SBD are 1.35 pF/mm and 0.70 pF/mm, respectively. Compared with the planar SBDs, the capacitances of lateral SBDs are reduced by about two orders of magnitude without sacrificing the performance of on-resistance (Ron) and reverse leakage current. For the planar and lateral n-GaN SBDs, the value of the Von is similar. However, compared with the planar AlGaN/GaN SBD, the Von of lateral AlGaN/GaN SBD is reduced from 1.64 V to 0.87 V owing to the anode metal directly contacting the two-dimensional electron gas. According to temperature-dependent I-V results, the barrier inhomogeneity of the lateral SBD is more intensive than the planar SBD, which is attributed to etching damage. The withstand voltage of SBD is a very important parameter for power electronic applications. Compared with the breakdown voltage of 73 V in the lateral n-GaN SBD, the lateral AlGaN/GaN SBDs exhibit a breakdown voltage of 2322 V. In addition, we found that Schottky contact introduces anode resistance (RA) by analysing the Ron distribution of lateral SBDs. The experimental results also show that the RA of lateral n-GaN SBD and lateral AlGaN/GaN SBD are 10.5 Ω mm and 9.2 Ω mm respectively, which are much larger than the ohmic contact resistance due to worsening anode contact by metal-induced gap states.
Influence of organic rice production mode on weed composition in the soil seed bank of paddy fields
Authors: Gao Pinglei , Wang Haoyu , Deng Shiwen , Dong Erjia , Dai Qigen 
Published: November 2022

IntroductionIt is of great significance to determine the composition of the soil weed seed bank under different organic rice production modes to provide decision making support for rational integrated weed management in organic rice production.MethodsThe soil weed seed bank of the four dominant organic production modes, namely, rice-green manure rotation (RG), rice monoculture (RM), rice-crayfish coculture (RC) and rice-duck coculture (RD), with different numbers of consecutive planting years (3 to 10 years) in different sites in Jiangsu Province were investigated to determine the influence of organic rice production mode on weed composition.Results and DiscussionThere were significant differences in the weed composition in the soil seed bank among the four organic rice production modes. The most dominant weed group was broadleaf weeds in the soil seed bank under the RG and RM modes; however, under the RM mode, the most dominant weed species were sedge and grass weeds. Sedge and grass weeds dominated the soil seed bank of the RC and RD modes, respectively. Therefore, specific weed management strategies could be formulated based on the differences in weed composition under different organic rice production modes. The application of organic fertilizer and irrigation were identified as primary factors associated with the differences in weed composition in the soil seed banks, which had higher effects on the weed composition than hand weeding. Consequently, fertilization and irrigation strategies that alter weed composition could be used as improved weed management program components in organic rice production systems. Long-term organic rice planting is beneficial for increasing weed diversity in paddy fields. Our results indicated that weed species diversity increased and weed community evenness and dominance decreased with the increase in the number of consecutive planting years under all four organic rice production modes.
Assessment of risk, landscape epidemiology and management strategies to combat alveolar echinococcosis in the rural communities of Hunza, Pakistan
Authors: Jamill Naila , Ahmed Haroon , Afzal Muhammad Sohail , Simsek Sami , Ali Abid , Arshad Muhammad , Yu Chenghang , Cao Jianping 
Published: November 2022

BackgroundHuman alveolar echinococcosis (AE) is a neglected zoonotic disease. Prevalence of AE in humans is reported in Pakistan as a result of poor economic and sanitary conditions, close proximity to wildlife and limited knowledge of AE. Studies on the prevalence and transmission of AE have been limited, especially for rural Pakistan. The study objectives were to identify knowledge, attitudes and practices relating to AE, to determine awareness of the disease, and to identify knowledge about possible risk factors of infections involving the landscape epidemiological attributes of rural villages in Hunza, one of the districts of Gilgit-Baltistan, a region of Pakistan that borders China.MethodsA community-based cross-sectional study was conducted among the general population of Hunza to establish the level of awareness, knowledge, attitudes, practices, landscape epidemiology, and disease management and control relating to AE in rural areas of Hunza. Data were collected by questionnaire.ResultsA total of 387 questionnaires was received. Statistical analysis showed that the population's knowledge about the disease was poor. The attitudes and practices of the participants indicated that their risk of infection was low. Knowledge of landscape epidemiology of the disease was poor but knowledge about AE disease management was good. The attitudes of residents toward disease treatment and control strategies were positive, although the overall knowledge of participants about prevention of infection was poor.ConclusionKnowledge of AE is poor among the residents of Hunza, Pakistan. Our study demands continued and strengthened awareness of the changes to lifestyle and practices associated with AE, not only in the study locality but throughout other areas of Pakistan.
The inclusion of disability and aging in COVID-19 hygiene behavior change interventions across low-and middle-income countries: A review using the COVID-19 Inclusive WASH Checklist
Authors: Wilbur Jane , Ferdous Sharika , Wapling Lorraine 
Published: November 2022

IntroductionPeople with disabilities and older adults face a high risk of dying from COVID-19. Handwashing with soap and sanitizing surfaces were recommended to disrupt COVID-19 transmission. Yet, in many low-and middle-income countries (LMICs), these populations have inadequate access to water, sanitation and hygiene (WASH) and are not reached by public health campaigns. The Hygiene Behavior Change Coalition (HBCC) was set up to limit the spread of COVID-19 in LMICs. Twenty organizations working across 37 countries were funded to encourage populations to adopt recommended personal hygiene behaviors. This study aims to review the inclusion of disability, aging, and caregiving in HBCC grantee interventions.MethodsA COVID-19 Inclusive WASH Checklist, which incorporates core concepts of human rights, was developed to support the inclusion of disability, aging and caregivers in interventions. The Checklist was applied to 137 documents submitted to donors within the HBCC fund to assess inclusion. Eligible grantee programme documents related to HBCC-funded projects were identified between August 2020 and January 2021. Feedback was provided to grantees recommending how to strengthen the inclusion of disability, aging, and caregiving.ResultsMost organizations identified people with disabilities, older adults and caregivers as target groups, but targeted activities to include them were scarce. Where efforts were made, immediate needs rather than rights were addressed. For example, the construction of accessible handwashing facilities featured more prominently than ensuring the participation of these groups. Examples of the coverage of core concepts in interventions included generating data with these groups and developing interventions accordingly. Limitations to inclusion were inconsistent organizational approaches, inability to monitor media campaigns, and inadequate coverage of disability and aging in donor's grant funding mechanisms.ConclusionTo ensure these populations benefit from efforts, they must be explicitly identified as target groups, with assigned actions that are monitored; efforts must go beyond accessible WASH services to ensure the meaningful participation of these groups. The COVID-19 Inclusive WASH Checklist supports this but requires further testing to assess its appropriateness and effectiveness.