bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficacy and Safety of Chinese Herbal Injection Thoracic Perfusion combined with Cisplatin chemotherapy for Lung Cancer Malignant Pleural Effusion: A Systematic Review and Meta-Analysis
Authors: He Zhong-Ning , Su Ming-Wan , Jie-He  , Zhu Guang-Hui , Zhao Yu-Wei , He Shu-Lin , Li Yue , Shi Bo-Lun , Hu Jia-Qi , Chen Shun-Tai , Hua Bao-Jin 
Published: December 2022

PurposeTo evaluate the efficacy and safety of Chinese herbal injection thoracic perfusion combined with cisplatin chemotherapy for lung cancer patients with MPE.MethodEight databases were searched for articles published from inception to August 20, 2022 for randomized-controlled trials (RCTs) that are relevant. The included studies were reviewed by two investigators, with relevant data extracted independently. Primary outcome was identified as objective response rate (ORR), while secondary outcomes were identified as quality of life (QOL) and adverse reactions. Quality of the included trials was assessed through risk of bias assessment of the Cochrane risk-of-bias tool. The Revman5.3 and Stata17.0 software were used to calculate risk ratio (RR) at 95% confidence intervals (CI) for binary outcomes.Results29 RCTs involving 1887 patients were included in this study. Compared with patients treated with cisplatin thoracic perfusion alone, those with Chinese herbal injection and cisplatin thoracic perfusion had better therapeutic effects (RR=1.44, 95% CI: 1.35∼1.53, P = 0.000), higher KPS score (RR = 1.47, 95%CI: 1.34∼1.61, P = 0.0000), lower digestive tract reaction(RR = 0.56, 95%CI: 0.48∼0.67, P = 0.000), bone marrow suppression (RR = 0.50, 95% CI: 0.43∼0.59, P =0.000) and chest pain reactions (RR = 0.65, 95%CI: 0.47∼0. 89, P = 0.007).ConclusionThe systematic review indicated that Chinese herbal injection thoracic perfusion combined with cisplatin chemotherapy may improve therapeutic effect, quality of life, and reduce adverse reactions. More large-scale and higher quality RCTs are warranted to support our findings. Systematic Review Registration: PROSPERO, identifier CRD42022347345.
Minimally invasive surgery with a tube-free surgical field for Tetralogy of Fallot repair: A single-center experience
Authors: Qiao Bin , Wei Zhenglun Alan , Si Biao , Zhang Fengquan , Zhu Meng , Chen Lei , Slesnick Timothy 
Published: December 2022

ABSTRACTObjectiveSeveral authors have detailed their experiences with small cohorts of patients in light of expanding interest in using minimally invasive surgery (MIS) to treat Tetralogy of Fallot (ToF). The goal of this study was to review an innovative MIS technique that results in a small tube-free surgical field. The technique’s clinical outcomes were examined in the largest cohort to date of patients with ToF treated with an MIS technique.MethodsWe reviewed all patients who underwent MIS at a single center between 2013 and 2017. The MIS procedure (including establishment of cavopulmonary bypass) is described. The inter-, peri- and postoperative data are reported and compared with those in the contemporary literature on ToF MIS.ResultsA total of 105 patients with ToF were identified. All patients, including 2 under 6 months of age, had good postoperative oxygen saturation (99% [98-100]). The incision size was 3 mm for patients younger than 3 years and 3-5 mm for older patients. No conversions to sternotomy or reinterventions were needed. Postoperative complications occurred in 14 patients (13.3%), including 1 death in the intensive care unit, which was not felt to be cardiac in origin. The primary hospital course metrics were comparable to previously published data.ConclusionsThe MIS technique with a tube-free surgical field has been successfully performed in 105 patients. The overall outcomes are favorable, including those for 2 patients younger than 6 months. This innovative MIS could be a promising approach for facilitating ToF repair in patients of all ages.Central PictureArtist depiction of operative incisions for the proposed minimally invasive surgery.Central MessageThis study shows the favorable outcomes of an innovative MIS technique with a tube-free surgical field by reviewing its use in 105 ToF patients, to date the largest cohort undergoing MIS for ToF.Perspective StatementThe proposed MIS technique with a tube-free surgical field presents a promising method for ToF repair; smaller incisions reduce patient pain, facilitate recovery, and enhance cosmesis. This technique achieved overall favorable outcomes for patients with ToF. Also, it can be a good option for early primary ToF repairs.
Antithrombotic Therapy After Heart Valve Surgery, Contemporary Practice in the United Kingdom
Authors: Laskar Nabila , Bayliss Christopher D , Akowuah Enoch , Kirmani Bilal H , Chambers John B , Maier Rebecca , Briffa Norman P , Cartwright Neil , Kendall Simon , Shah Benoy Nalin 
Published: December 2022

ABSTRACTObjectivesThere is a lack of high-quality data informing the optimal antithrombotic drug strategy following bioprosthetic heart valve replacement or valve repair. Disparity in recommendations from international guidelines reflects this. This study aimed to document current patterns of antithrombotic prescribing after heart valve surgery in the United Kingdom.MethodsAll UK consultant cardiac surgeons were e-mailed a custom-designed survey. The use of oral anticoagulant (OAC) and/or antiplatelet drugs following bioprosthetic aortic (AVR) or mitral valve replacement (MVR), or mitral valve repair (MVrep), for patients in sinus rhythm, without additional indications for antithrombotic medication, was assessed. Additionally, we evaluated anticoagulant choice following MVrep in patients with atrial fibrillation (AF).ResultsWe identified 260 UK consultant cardiac surgeons from 36 units, of whom 103 (40%) responded, with 33 units (92%) having at least one respondent. The greatest consensus was for patients undergoing bioprosthetic AVR, in which 76% of surgeons favour initial antiplatelet therapy and 53% prescribe lifelong treatment. Only 8% recommend initial OAC. After bioprosthetic MVR, 48% of surgeons use an initial OAC strategy (versus 42% antiplatelet), with 66% subsequently prescribing lifelong antiplatelet therapy. After MVrep, recommendations were lifelong antiplatelet agent alone (34%) or following 3 months OAC (20%), no antithrombotic agent (20%), or 3 months OAC (16%). After MVrep for patients with established AF, surgeons recommend warfarin (38%), a direct oral anticoagulant (37%) or have no preference between the two (25%).ConclusionThere is considerable variation in the use of antithrombotic drugs after heart valve surgery in the UK. This reflects the lack of high-quality evidence and underscores the need for randomised studies.KEY MESSAGESWhat is already known on this topic?The most appropriate antithrombotic drug regime following bioprosthetic heart valve replacement or mitral valve repair is not known. Contemporary practice in the UK has not been established.What this study addsThis study demonstrates wide variation in antithrombotic drug choice and duration following bioprosthetic heart valve replacement or mitral valve repair in the UK.How this study might affect research, practice, or policyRandomised studies are required to assess the most appropriate antithrombotic strategy after heart valve surgery.
The role of a population of descending neurons in the optomotor response in flyingDrosophila
Authors: Palmer Emily H. , Omoto Jaison J. , Dickinson Michael H. 
Published: December 2022

SUMMARYTo maintain stable flight, animals continuously perform trimming adjustments to compensate for internal and external perturbations. Whereas animals use many different sensory modalities to detect such perturbations, insects rely extensively on optic flow to modify their motor output and remain on course. We studied this behavior in the fruit fly,Drosophila melanogaster, by exploiting the optomotor response, a robust reflex in which an animal steers so as to minimize the magnitude of rotatory optic flow it perceives. Whereas the behavioral and algorithmic structure of the optomotor response has been studied in great detail, its neural implementation is not well-understood. In this paper, we present findings implicating a group of nearly homomorphic descending neurons, the DNg02s, as a core component for the optomotor response in flyingDrosophila. Prior work on these cells suggested that they regulate the mechanical power to the flight system, presumably via connections to asynchronous flight motor neurons in the ventral nerve cord. When we chronically inactivated these cells, we observed that the magnitude of the optomotor response was diminished in proportion to the number of cells silenced, suggesting that the cells also regulate bilaterally asymmetric steering responses via population coding. During an optomotor response, flies coordinate changes in wing motion with movements of their head, abdomen, and hind legs, which are also diminished when the DNg02 cells are silenced. Using two-photon functional imaging, we show that the DNg02 cells respond most strongly to patterns of horizontal motion and that neuronal activity is closely correlated to motor output. However, unilateral optogenetic activation of DNg02 neurons does not elicit the asymmetric changes in wing motion characteristic of the optomotor response to a visual stimulus, but rather generates bilaterally symmetric increases in wingbeat amplitude. We interpret our experiments to suggest that flight maneuvers in flies require a more nuanced coordination of power muscles and steering muscles than previously appreciated, and that the physical flight apparatus of a fly might permit mechanical power to be distributed differentially between the two wings. Thus, whereas our experiments identify the DNg02 cells as a critical component of the optomotor reflex, our results suggest that other classes of descending cells targeting the steering muscle motor neurons are also required for the behavior.
Identifying farmers' preferences for types of credit and its market structure in rural Benin using the conjoint analysis approach
Authors: Sonehekpon Emile Sègbégnon , Fiamohe Rose 
Published: December 2022

PurposeThis study analyzes farmers' preferences for agricultural credit and its market structure in rural Benin using the conjoint analysis approach.Design/methodology/approachThe data used come from primary sources collected from 228 randomly selected farmers. The conjoint analysis approach was used to produce the results. The bias associated with the heteroscedasticity of the error terms was fixed using the weighted least squares estimation method. Agricultural credit markets were segmented using the Calinski algorithm.FindingsThe study results reveal that farmers prefer a long-term agricultural credit with a low interest rate received via mobile banking. The interaction between a type of credit with collateral and a low interest rate is positively correlated with farmers' credit demand. The authors also found that agricultural credit markets are heterogeneous because of the heterogeneity in farmers' credit demand. This result has led to three different rural credit market segments identified in the selected study's sites. The market share simulation reveals a significant market share for the type of credit preferred by farmers in two segments.Research limitations/implicationsThe proven evidence from this study can guide the development of appropriate agricultural financial products that promote financial inclusion among farmers in rural Benin. More specifically, agricultural financial policies that promote digital long-term credit with low interest rate and appropriate guarantee mechanisms can promote financial inclusion among farmers and reduce the problem of asymmetric information in agricultural credit market. The study also calls for the promotion of differentiated policies across the three identified segments in order to positively impact the welfare of all farmers.Practical implicationsThe use of agricultural financial products that include digital long-term credit with low interest rate and appropriate guarantee mechanisms promote financial inclusion and reduce asymmetric information problems in agricultural credit markets in rural Benin.Social implicationsThe promotion of long-term digital and cheap credit improves farmers household's wellbeing in rural Benin.Originality/valueThis study contributes to a better understanding of the structure of rural credit markets. It also reveals the most preferred characteristics of rural credit profiles by farmers. Besides, it validates the importance of the use of guarantee as an appropriate mechanism which minimizes the problem of asymmetric information between financial agents and farmers.
Heuristic design and modelling of modified interleaved boost converter for E-mobility control
Authors: Sampath Suresh , Rahiman Zahira , Kalavai Shafeeque Ahmed , Veerasamy Bharanigha , Mekhilef Saad 
Published: December 2022

Purpose
This study aims to present a modified interleaved boost converter (MIBC) topology for improving the reliability and efficiency of power electronic systems.

Design/methodology/approach
The MIBC topology was implemented with two parallel converters, operated with a −180 degree phase shift. Using this methodology, ripples are reduced. The state-space model was analysed with a two-switch MIBC for different modes of operation. The simulation was carried out and validated using a hardware prototype.

Findings
The performance of the proposed MIBC shows better output voltage, current and power than the interleaved boost converter (IBC) for the solar PV array. The output power of the proposed converter is 1.353 times higher than that of existing converters, such as boost converter (BC) and IBC. The output power of the four-phase IBC is 30 kW, whereas that of the proposed two-phase MIBC is 40.59 kW. The efficiency of MIBC was better than that of IBC (87.01%). By incorporating interleaved techniques, the total inductor current is reduced by 29.60% compared with the existing converter.

Practical implications
The proposed MIBC can be used in a grid-connected system with an inverter circuit for DC-to-AC conversion, electric vehicle speed control, power factor correction circuit, high-efficiency converters and battery chargers.

Originality/value
The work presented in this paper is a modified version of IBC. This modified MIBC was modelled using the state-space approach. Furthermore, the state-space model of a two-phase MIBC was implemented using a Simulink model, and the same was validated using a hardware setup.
Equity bank: repositioning as a fintech
Authors: Kiburu Lydiah , Mungai Edward 
Published: December 2022

Learning outcomes
The learning objectives of this case include:
▪ Outline the brand repositioning approaches that Equity Bank used in its various stages of growth.
▪ Identify the impact of Equity’s brand repositioning in supporting its growth.
▪ Develop a brand repositioning framework for Equity bank as a fintech.
▪ Identify the theoretical frameworks that informed Equity’s brand repositioning during the various growth stages.
▪ Suggest a theoretical framework that would help Equity to reposition the new brand in the market.

Case overview/synopsis
In March 2020, the Government of Kenya declared a lockdown to slow down the spread of the Covid-19 pandemic. The lockdown of entire economic sectors put pressure on the adoption of technology to deliver services such as education, training and financial services. Banks had to innovate ways of supporting customers transactions with minimal physical and cash contact. Equity Bank had been implementing a digital banking strategy which had demonstrated successful adoption. Covid-19 accelerated the adoption and usage of Equity Bank’s digital banking by consumers. The bank found itself in a new territory competing fiercely with new and more agile fintechs. Consequently, Dr James Mwangi, the Group Managing Director and CEO of Equity Group, was contemplating the possibility of bringing forward the bank's strategic intention of repositioning as a fintech. He was convinced that such a move would bring massive success to the bank’s digital banking strategy, achieve enhanced efficiency, improve customer experience and attract a new segment of digital-savvy customers. But he needed to carry the Board, his management team and customers along in this repositioning strategy without sacrificing the gains made in the consumers' minds about Equity's brand as a bank.

Complexity academic level
This case can be taught to graduate-level students of marketing courses. It can also be taught to participants of executive education undertaking short courses in in business management and entrepreneurship.

Supplementary materials
Teaching notes are available for educators only.

Subject code
CSS 8: Marketing.
The “epidemic within the pandemic”: meeting the needs of racially minoritised women experiencing domestic abuse during the Covid-19 pandemic
Authors: Magill Severyna 
Published: December 2022

Purpose
In March 2020, the UK entered its first lockdown responding to the Covid-19 pandemic. In the same month, the Domestic Abuse Bill had its first reading in Parliament. Charities and non-governmental organisations critiqued the Bill for failing to protect migrants from domestic abuse, and not complying with the Istanbul Convention. Drawing on interviews with staff from Southall Black Sisters, this paper aims to foreground the experiences of practitioners within the women’s sector to explore the unique experiences and challenges migrant and racially minoritised women encountered when seeking support from domestic abuse during the Covid-19 pandemic. It highlights how the pandemic-related lockdowns created barriers to accessing support services and housing, creating an epidemic within the pandemic, and how minoritised women and the organisations that supported them had to overcome structural barriers and racism.

Design/methodology/approach
In-depth semi-structured interviews were conducted with staff from a leading women’s organisation that supports migrant and racially minoritised women. Four participants were asked questions within four themes: domestic abuse before and during the pandemic; accessing support from and reporting domestic abuse; accessibility of resources; and post-pandemic challenges. A phenomenological approach was used to analyse the transcribed interviews.

Findings
Participants consistently highlighted the unique threats and barriers migrant and racially minoritised women faced when seeking support. Barriers included racism, language barriers, cultural constraints, the triple threat of destitution, detention, deportation, and political resistance to protect migrant women from destitution/homelessness.

Originality/value
This paper provides a unique insight into the experiences of staff members within a specialist by and for women’s support organisation in England and their perspectives on the barriers racially minoritised and migrant women experienced during the Covid-19 pandemic. It offers rare insights into how service users’ needs changed during the lockdowns and how the pandemic affected their ability to operate.
Braided identities in acute care nurses' practices of work: professional, clinician, employee
Authors: Lake Sarah , Rudge Trudy , West Sandra 
Published: December 2022

PurposeThis paper aims to explore how dispositions of nursing habitus carry shift handover into practice in acute care.Design/methodology/approachHandover (the exchange of information by nurses between shifts) is more recently purported to be a procedure that transfers the responsibility of and accountability for care to maintain patient safety. Using Bourdieu's theory of practice as lens, this paper examines data from an ethnographic study of nurses' work in acute care to reveal what happens in and around nurses' practices of handover.FindingsExploring handover as a practice enables identification of nurses' responsibilities of work as professional, clinician and employee. These responsibilities are not practised separately, rather, as braided identities they are embodied into nurses' practices of work. Nurses' clinician and employee identities address the clinical and organisationally relevant material contained in handover, but it is in the ways that nurses embody their responses that their professional identity becomes evident.Research limitations/implicationsViewing handover as a procedure suggests that nurses are rule followers and/or sole players and conceptualises nurses as individualised professionals only. This received knowledge as doxa misrecognises the centrality of connectedness between nurses in their work in the acute care setting.Originality/valueRecognising nurses' braided workplace identities as being professional, clinician and employee upends the doxa of nurses work as tasks and roles in the delivery of healthcare in the acute care setting.
A holistic view of academic library supply chain model
Authors: Hye A.K. Mahbubul , Mustaffa Nurakmal Ahmad , Habib Md. Mamun 
Published: December 2022

PurposeThe supply chain (SC) model is commonly utilized in manufacturing and has also been adapted to a variety of service industries with similar goals. However, in a few service industries, most notably academic libraries, the SC model is rarely implemented, despite the fact that SC management best practises have been shown to boost stakeholder satisfaction, revenue and decrease total expenses. This research aims to discuss the development of the entities of an academic library SC model and present the verifying/validation process of the model.Design/methodology/approachIn this research, both qualitative and quantitative approaches have been used. System thinking method used to develop the conceptual SC model of the academic library and fuzzy Delphi method (FDM) used to validate the developed model.FindingsThis research explores the functions and components that need to develop and validate the academic library SC model.Originality/valueThe outcome of this research is to construct a valid SC model of an academic library which could be a strategical tool for ensuring a quality service for the library users and the stakeholders because this model shows a holistic view of all entities of the academic library SC.
Differential expression of myosin heavy chain isoforms type II in skeletal muscles of polar and black bears
Authors: Kawata Mutsumi , Luziga Claudius , Miyata Hirofumi , Sugiura Takao , Wada Naomi 
Published: December 2022

AbstractIn this study, the pattern of myosin heavy chain (MHC) isoforms expression in skeletal muscles of the trunk, forelimb and hindlimb in Polar Bear (PB) Ursus maritimus; American Black Bear (AmBB), Ursus americanus and Asian Black Bear (AsBB), Ursus thibetanus was analysed by immunohistochemistry and SDS‐PAGE. Results showed that slow (MHC‐I) and fast (MHC‐II) isoforms exist in muscles of bears. Type II fibres were classified further into Type IIa and IIx in PB but not in AsBB and AmBB. The distribution of Type I and Type II fibres in the trunk, forelimb and hindlimb varied based on muscle type and animal species. The proportions of Type I fibres formed approximately one‐third of muscle composition in PB (trunk, 32.0%; forelimb, 34.7%; hindlimb, 34.5%) and a half in both AsBB and AmBB whereas Type IIa and IIx formed approximately two‐third in PB (trunk, 68.0%; forelimb, 65.3%; hindlimb, 65.5%) and a half of Type II in both AmBB and AsBB. PB is a good swimmer, lives in Arctic Ocean on slippery ice catching aquatic mammals such as seals and is larger in size compared to the medium sized AmBB (living in forest) and AsBB (arboreal). The results suggest that in bears, there is greater diversity in MHC isoforms II, being expressed in selected fast contracting skeletal muscles in response to variety of environments, weight bearing and locomotion.