bluuebunny/crossref_metadata_2025_split huggingface dataset:
Implementing the Care of Persons With Dementia in Their Environments (COPE) Intervention in Community-Based Programs: Acceptability and Perceived Benefit From Care Managers’ and Interventionists’ Perspectives
Authors: Kellett Kathy , Robison Julie , McAbee-Sevick Heather , Gitlin Laura N , Verrier Piersol Catherine , Fortinsky Richard H 
Published: May 2022

Abstract

Background and Objectives
Nonpharmacologic interventions have demonstrated benefits for people living with dementia and their caregivers. Few studies have evaluated their implementation in real-world settings. Using normalization process theory (NPT), an implementation science framework, this study evaluated the acceptability of the care of persons with dementia in their environments (COPE) intervention by care managers and interventionists implemented in a Medicaid and state-revenue funded home and community-based services (HCBS) program.

Research Design and Methods
NPT and data from 9 care manager focus groups (n = 61) and 2 interventionist focus groups (n = 8) were utilized to understand COPE acceptability to program care managers and interventionists. NPT’s 4 criteria, coherence, cognitive participation, collective action, and reflexive monitoring, framed the research questions used to evaluate the intervention’s implementation.

Results
Care managers and interventionists demonstrated a shared understanding of COPE aims and the value of practices implemented (coherence). Training by national experts facilitated program buy-in to meet COPE goals and was demonstrated by care managers and interventionists as they used the training to broaden their program involvement (cognitive participation). Operational work done by care managers and interventionists to implement the intervention (collective action) and their shared perceptions of program benefits (reflexive monitoring) contributed to program implementation, families’ positive responses to COPE and enhanced sustainability.

Discussion and Implications
Introducing evidence-based dementia care interventions into HCBS programs strongly depends upon building shared understandings between care managers and interventionists and valuing the contributions of all stakeholders involved in delivering care innovations to people living with dementia and their caregivers.
Effects of dietary vitamin E and fat supplementation in growing-finishing swine fed to a heavy slaughter weight of 150 kg: II. Tissue fatty acid profile, vitamin E concentrations, and antioxidant capacity of plasma and tissue
Authors: Wang Ding , Jang Young Dal , Rentfrow Gregg K , Azain Michael J , Lindemann Merlin D 
Published: May 2022

AbstractThe study aimed to assess the effects of vitamin E (VE) supplementation and fat source on fatty acid (FA) composition, VE concentrations, and antioxidant capacity in plasma and tissues of pigs fed to a heavy slaughter weight (150 kg). A total of 64 pigs (32 barrows, 32 gilts; 28.41 ± 0.83 kg) were blocked by sex and weight, and randomly assigned to one of eight dietary treatments (n = 8 per treatment) in a 4 × 2 factorial arrangement. Fat sources included corn starch (CS), 5% tallow (TW), 5% distiller’s corn oil (DCO), and 5% coconut oil (CN); VE supplementation levels were 11 and 200 ppm. Five-phase diets were formulated to meet requirement estimates of NRC (2012) and fed to pigs for each period of 25 kg from 25 to 150 kg. Increasing VE supplementation level increased C16:1 (P &lt; 0.05) content but decreased C20:0 (P &lt; 0.05) content in backfat and belly fat, while in liver, it increased C17:0 (P &lt; 0.05) but decreased C18:0 (P &lt; 0.05). Compared to the pigs fed the CS diet, the pigs fed the CN diet had greater (P &lt; 0.05) content of total saturated FA, the pigs fed the DCO diet had greater (P &lt; 0.05) content of total polyunsaturated FA content and iodine value, and the pigs fed the TW diet had greater (P &lt; 0.05) content of total monounsaturated FA in backfat, belly fat, and liver. Plasma VE concentrations increased linearly (P &lt; 0.05) with increasing length of feeding but faster (P &lt; 0.05) in the pigs fed the CN and TW diets compared with the CS and DCO diets within the 200 ppm VE level; the pigs fed the DCO diet had the highest plasma VE concentrations (P &lt; 0.05) from Phase 2 to Phase 5 within the 11 ppm VE level. The VE concentrations in liver and loin muscle (P &lt; 0.05) increased with increasing dietary VE level from 11 to 200 ppm, but it was not affected by dietary fat source. There was no effect of VE supplementation and fat source on antioxidant capacity in plasma and liver except that pigs fed the DCO diet had greater liver SOD activity (P &lt; 0.05) than the pigs fed the CN diet. In conclusion, dietary VE supplementation did not affect FA profile in backfat, belly fat, and liver consistently, while dietary FA composition with different fat sources affected much of the FA profile in backfat, belly fat, and liver. The higher level of VE supplementation increased liver and muscle VE concentrations and dietary fat sources affected plasma VE concentrations differently (P &lt; 0.05), wherein the TW and CN diets increased the VE absorption greater than the DCO diet.
Efficacy of Silk Sericin and Jasminum grandiflorum L. Leaf Extract on Skin Injuries Induced by Burn in Mice
Authors: Ahmed Asmaa Bashir , Tahir Hafiz Muhammad , Yousaf Muhammad Shahbaz , Munir Fareeha , Ali Shaukat 
Published: May 2022

Abstract
Burns wounds are one of the most health-threatening problems worldwide. Sericin is a natural protein synthesized by the silkworm Bombyx mori L. It is a natural biomaterial that helps in the management of wounds by promoting the proliferation of fibroblasts and keratinocytes. Jasminum grandiflorum L leaves contain high mucilage content and have been used to cure various dermal wounds in ancient times. The present study was aimed to investigate the individual and synergetic effect of sericin and J. grandiflorum leaves extract on burn injury in mice. Ten-week-old mice weighing 22 g ± 5 g were randomly divided into eight groups, each group containing 10 mice. Burn injury in mice was induced by using a hot metal rod. Wounds were evaluated morphologically and histologically. In comparison with controls, 4% sericin + jasmine (S + J) expressively improved wound contraction area. Restoration of the epidermis was also faster in S + J 4% group (P ≤ .01) than in other groups. Histopathological analysis also verified the efficacy of the 4% S + J cream. It is concluded that a mixture of sericin and jasmine leaves effectively improved the healing process of skin burns.
Dysplacement and the Professionalization of the Home
Authors: Grant Annetta , Handelman Jay M 
Published: May 2022

AbstractThis research directs our attention to the dynamics surrounding the changing cultural understanding of the place we call home. Traditionally, the home is regarded as a place of singularization that is to be aligned with the homeowner’s unique identity. This traditional meaning has come to be confronted with a contradictory understanding of the home as a marketplace asset. Homeowners come to experience a market-reflected gaze that shuns singularization while driving homeowners to exhibit expertise in aligning their homes with marketplace standards. Professionalization of the home, through marketplace expertise and standardization, discourages personalization, leading to an experience of disorientation with the place of home. In this ethnography of the home renovation marketplace, we build on the concept of ‘dysplacement’ whereby this contradictory cultural understanding of the home disrupts the homeowner’s ability to achieve implacement. The concept of dysplacement and the corresponding place disorientation experience has the potential to enrich our theoretical understanding of place by integrating the cultural meaning of place as a domain with marketplace dynamics and individual consumer practices surrounding place.
Ketamine Regulates the Autophagy Flux and Polarization of Microglia through the HMGB1-RAGE Axis and Exerts Antidepressant Effects in Mice
Authors: Wu Meng , Zhao Lin , Wang Ye , Guo Qianqian , An Qi , Geng Jie , Zhang Changsheng , Guo Zhenggang 
Published: May 2022

Abstract
Depression is a leading cause of disability worldwide. Here, we explored the role of the HMGB1-RAGE pathway in lipopolysaccharide (LPS)-induced depression-like behavior and microglial autophagy flux, neuroinflammation, and polarization in a mouse model. Male C57BL/6 mice were infused with LPS in the abdominal cavity to induce a depression model. They then underwent testing to assess behavior and cognition. Real-time fluorescent quantitative polymerase chain reaction was used to detect the expression of the M1/M2 microglia polarization markers, HMGB1, and RAGE. Microglial activation and phenotypic transformation in the hippocampus were identified. mRFP-GFP-LC3 and Western blotting were used to detect autophagy flux in each treatment group. Finally, an LPS-induced BV2 cell model was developed to verify the involvement of the HMGB1-RAGE pathway, autophagy flux, and polarization. Ketamine improved LPS-induced depression-like behavior, inhibited the LPS-induced upregulation of HMGB1 and RAGE and the nuclear translocation of HMGB1. Moreover, ketamine reversed the blocked autophagy flux of microglia caused by LPS and regulated microglial autophagy flux through the HMGB1-RAGE pathway and microglial polarization. These results suggest that ketamine may reduce HMGB1 and RAGE accumulation in patients with depression, thereby providing a new therapeutic target for preventing and treating this disease.
Corona, Lime, Sun, Rash: A Case Report of Severe Phytophotodermatitis in an Active Duty Soldier
Authors: Carius Brandon M , Bridwell Rachel E , Hawkins Anthony 
Published: May 2022

ABSTRACT
Dermatological complaints constitute a large portion of patient visits to both emergency departments and military clinics. Proper assessment to separate the benign diagnoses from life-threatening may prove challenging based on seemingly non-specific history and physical examination. Similarly, reflexive specialty consultation may delay treatment and overload the health care system. Phytophotodermatitis is caused by contact with sensitizing agents, including lime juice, which triggers localized skin reactions when exposed to ultraviolet A light. The resulting progression of erythema, edema, pain, and non-pruritic skin lesions presents a unique pattern limited to the area of initial psoralen contact. This uniquely limited pattern coupled with specific historical context provides evidence for diagnosis. We highlight the case of a 24-year- old otherwise healthy female returning from a leisure trip to Mexico with progressive worsening of erythematous bullae limited to her hands and wrists bilaterally, ultimately attributed to phytophotodermatitis from lime wedge exposure in her alcoholic beverages, commonly referred to as “Mexican Beer Hand.” Despite the severity of her initial appearance, her symptoms resolved without complication from limited supportive care.
Can Beta-D-Glucan testing as part of the diagnostic pathway for invasive fungal infection reduce anti-fungal treatment costs?
Authors: Hamilton David O , Lambe Tosin , Howard Alexander , Crossey Patricia , Hughes Jennifer , Duarte Rui , Welters Ingeborg D 
Published: May 2022

Abstract

We performed a cost comparison of the current diagnostic and treatment pathway for invasive fungal infection (IFI) versus a proposed pathway that incorporates Beta-D-Glucan (BDG) testing from the NHS perspective. A fungal pathogen was identified in 58/107 (54.2%) patients treated with systemic anti-fungals in the Critical Care Department. Mean therapy duration was 23 days (standard deviation [SD] = 22 days), and cost was £5590 (SD = £7410) per patient. Implementation of BDG tests in the diagnostic and treatment pathway of patients with suspected IFI could result in a mean saving of £1643 per patient should a result be returned within 2 days.

Lay Summary
Invasive fungal infection increases the risk of death in very sick people. So, treatment is started before test results are known. Beta-D-Glucan (BDG) test is faster than standard blood culture tests. We estimate that using BDG tests in how patients are diagnosed could save about £1643 per patient.
Mountain formation by repeated, inhomogeneous crustal failure in a neutron star
Authors: Kerin A D , Melatos A 
Published: May 2022

ABSTRACT
The elastic crust of a neutron star fractures repeatedly as it spins down electromagnetically. An idealized, macroscopic model of inhomogeneous crustal failure is presented based on a cellular automaton with nearest-neighbour tectonic interactions involving strain redistribution and thermal dissipation. Predictions are made of the size and waiting-time distributions of failure events, as well as the rate of failure as the star spins down. The last failure event typically occurs when the star spins down to $\approx 1{{\ \rm per\ cent}}$ of its birth frequency with implications for rotational glitch activity. Neutron stars are commonly suggested as sources of continuous gravitational waves. The output of the automaton is converted into predictions of the star’s mass ellipticity and gravitational wave strain as functions of its age, with implications for future observations with instruments such as the Laser Interferometer Gravitational Wave Observatory (LIGO).
The star formation rates of QSOs
Authors: Symeonidis M , Maddox N , Jarvis M J , Michałowski M J , Andreani P , Clements D L , De Zotti G , Duivenvoorden S , Gonzalez-Nuevo J , Ibar E , Ivison R J , Leeuw L , Page M J , Shirley R , Smith M W L , Vaccari M 
Published: May 2022

ABSTRACT
We examine the far-infrared (FIR) properties of a sample of 5391 optically selected QSOs in the 0.5 &lt; z &lt; 2.65 redshift range down to log [νLν, 2500(erg s−1)] &gt; 44.7, using SPIRE data from Herschel-ATLAS. We split the sample in a grid of 74 luminosity–redshift bins and compute the average optical–IR spectral energy distribution (SED) in each bin. By normalizing an intrinsic active galactic nucleus (AGN) template to the AGN optical power (at 5100 Å), we decompose the total IR emission (LIR; 8–1000 µm) into an AGN (LIR, AGN) and star-forming component (LIR, SF). We find that the AGN contribution to LIR increases as a function of AGN power, manifesting as a reduction of the ‘FIR bump’ in the average QSO SEDs. We note that LIR, SF does not correlate with AGN power; the mean star formation rates (SFRs) of AGN host galaxies are a function of redshift only and they range from ∼6 M⊙ yr−1 at z ∼ 0 to a plateau of ≲ 200 M⊙ yr−1 at z ∼ 2.6. Our results indicate that the accuracy of FIR emission as a proxy for SFR decreases with increasing AGN luminosity. We show that, at any given redshift, observed trends between IR luminosity (whether monochromatic or total) and AGN power (in the optical or X-rays) can be explained by a simple model which is the sum of two components: (i) the IR emission from star formation, uncorrelated with AGN power and (ii) the IR emission from AGN, directly proportional to AGN power in the optical or X-rays.
Nucleoporin37 may play a role in early embryo development in human and mice
Authors: Peng Yawen , Shen Jiandong , Gao Yan , Dai Wangjuan , Liang Shuang , Chen Jing , Gao Li , Lin Yuting , Cai Lingbo , Qin Lianju , Cui Yugui , Liu Jiayin , Diao Feiyang 
Published: May 2022

Abstract
Maternal-effect genes (MEGs) play an important role in maintaining the survival and development of mammalian embryos at the cleavage stage after fertilization. Despite long-term efforts, the MEGs that regulate preimplantation embryo development remain largely unknown. Here, using Whole-exome sequencing (WES) and homozygosity mapping, we identified a potential candidate gene associated with early embryo development: nucleoporin37 (NUP37), a nucleoporin gene that encodes a member of the nuclear pore complexes (NPCs) and regulates nuclear pore permeability and nucleocytoplasmic transport. Moreover, we determined the temporal and spatial expression patterns of Nup37 in mouse oocytes and early embryos, and explored the role of NUP37 in oocyte maturation and preimplantation embryo development. Immunoprecipitation assays confirmed that YAP1 binds to TEAD4 and NUP37. Furthermore, Nup37 gene knockdown reduced the nuclear import of YAP1 and downregulated the expression of YAP1-TEAD pathway downstream genes Rrm2 and Rpl13 in early embryos. Our study provides evidence that maternal NUP37 contributes to the nuclear import of YAP1 and then activates the YAP1-TEAD pathway, a signaling pathway essential for zygotic genome activation (ZGA). Nup37 may be a key gene involved in preimplantation embryo development in mammals.
Mycobacterium abscessus Infections in Solid Organ Transplant Recipients: Single-Center Experience in the United States, 2013–2018
Authors: Ebisu Yosuke , Natori Yoichiro , Rosello Gemma , Anjan Shweta , Simkins Jacques , Camargo Jose F , Morris Michele I , Martinez Octavio V , Abbo Lilian M 
Published: May 2022

Abstract

Background
Mycobacterium abscessus is increasingly recognized as a human pathogen causing life-threatening infections in immunocompromised patients. There is a paucity of data around this topic in solid organ transplant (SOT) recipients.

Methods
This work was a single-center retrospective cohort study of all SOT recipients with a positive culture for M abscessus between 2013 and 2018.

Results
A total of 20 patients (55% female) met inclusion criteria, including 1 kidney recipient (5.0%), 2 liver recipients (10.0%), 12 lung recipients (60.0%), 1 heart recipient (5.0%), and 4 combined organ recipients (20.0%). The median time from SOT to infection was 100 days (range, 30–431 days). Thirteen (65.0%) patients (1 kidney, 1 heart, 7 lung, 1 liver, 1 intestine, and 2 multivisceral) were treated with a median duration of 185 antibiotic days (range, 20–523 days). Among them, M abscessus was isolated from respiratory samples in 8 and nonrespiratory samples in 5; 4 of 13 (30.8%) patients had treatment failure and 3 of 13 (23.1%) had unrelated deaths within 1 year after diagnosis. Seven patients (5 lung transplant recipients) with the organism isolated from respiratory samples were not treated as their cultures represented airway colonization or contamination; of those, 2 (28.6%) died (unrelated to infection) and 5 (71.4%) were alive without the infection after 1 year of follow-up.

Conclusions
Mycobacterium abscessus infections affect SOT recipients with a high proportion of clinical failures. However, in lung recipients, not all positive cultures correlated with infection, and without treatment some patients had good clinical outcomes. Thus, differentiating colonization from infection is important, and infection prevention measures and novel therapeutic agents are needed for SOT recipients.
COVID-19, crisis responses, and public policies: from the persistence of inequalities to the importance of policy design
Authors: Béland Daniel , He Alex Jingwei , Ramesh M 
Published: May 2022

AbstractThe coronavirus (COVID-19) pandemic has once again highlighted the importance of social inequalities during major crises, a reality that has clear implications for public policy. In this introductory article to the thematic issue of Policy and Society on COVID-19, inequalities, and public policies, we provide an overview of the nexus between crisis and inequality before exploring its importance for the study of policy stability and change, with a particular focus on policy design. Here, we stress the persistence of inequalities during major crises before exploring how the COVID-19 pandemic has highlighted the need to focus on these inequalities when the time comes to design policies in response to such crises. Paying close attention to the design of these policies is essential for the study of, and fight against, social inequalities in times of crisis. Both during and beyond crises, policy design should emphasize tackling with inequalities. This is the case because current design choices shape future patterns of social inequality.
Crosslinking and functionalization of acellular patches via the self-assembly of copper@tea polyphenol nanoparticles
Authors: Li Qin , Gao Yuan , Zhang Jiajun , Tang Yangfeng , Sun Yangyong , Wu Lujia , Wu Hao , Shen Meifang , Liu Xiaohong , Han Lin , Xu Zhiyun 
Published: May 2022

Abstract
Decellularization is a promising technique to produce natural scaffolds for tissue engineering applications. However, non-crosslinked natural scaffolds disfavor application in cardiovascular surgery due to poor biomechanics and rapid degradation. Herein, we proposed a green strategy to crosslink and functionalize acellular scaffolds via the self-assembly of copper@tea polyphenol nanoparticles (Cu@TP NPs), and the resultant nanocomposite acellular scaffolds were named as Cu@TP-dBPs. The crosslinking degree, biomechanics, denaturation temperature and resistance to enzymatic degradation of Cu@TP-dBPs were comparable to those of glutaraldehyde crosslinked decellularized bovine pericardias (Glut-dBPs). Furthermore, Cu@TP-dBPs were biocompatible and had abilities to inhibit bacterial growth and promote the formation of capillary-like networks. Subcutaneous implantation models demonstrated that Cu@TP-dBPs were free of calcification and allowed for host cell infiltration at Day 21. Cardiac patch graft models confirmed that Cu@TP-dBP patches showed improved ingrowth of functional blood vessels and remodeling of extracellular matrix at Day 60. These results suggested that Cu@TP-dBPs not only had comparable biomechanics and biostability to Glut-dBPs, but also had several advantages over Glut-dBPs in terms of anticalcification, remodeling and integration capabilities. Particularly, they were functional patches possessing antibacterial and proangiogenic activities. These material properties and biological functions made Cu@TP-dBPs a promising functional acellular patch for cardiovascular applications.
Target Enrichment and Extensive Population Sampling Help Untangle the Recent, Rapid Radiation of Oenothera Sect. Calylophus
Authors: Cooper Benjamin J , Moore Michael J , Douglas Norman A , Wagner Warren L , Johnson Matthew G , Overson Rick P , Kinosian Sylvia P , McDonnell Angela J , Levin Rachel A , Raguso Robert A , Flores Olvera Hilda , Ochoterena Helga , Fant Jeremie B , Skogen Krissa A , Wickett Norman J 
Published: May 2022

Abstract
Oenothera sect. Calylophus is a North American group of 13 recognized taxa in the evening primrose family (Onagraceae) with an evolutionary history that may include independent origins of bee pollination, edaphic endemism, and permanent translocation heterozygosity. Like other groups that radiated relatively recently and rapidly, taxon boundaries within Oenothera sect. Calylophus have remained challenging to circumscribe. In this study, we used target enrichment, flanking noncoding regions, gene tree/species tree methods, tests for gene flow modified for target-enrichment data, and morphometric analysis to reconstruct phylogenetic hypotheses, evaluate current taxon circumscriptions, and examine character evolution in Oenothera sect. Calylophus. Because sect. Calylophus comprises a clade with a relatively restricted geographic range, we were able to extensively sample across the range of geographic, edaphic, and morphological diversity in the group. We found that the combination of exons and flanking noncoding regions led to improved support for species relationships. We reconstructed potential hybrid origins of some accessions and note that if processes such as hybridization are not taken into account, the number of inferred evolutionary transitions may be artificially inflated. We recovered strong evidence for multiple evolutionary origins of bee pollination from ancestral hawkmoth pollination, edaphic specialization on gypsum, and permanent translocation heterozygosity. This study applies newly emerging techniques alongside dense infraspecific sampling and morphological analyses to effectively reconstruct the recalcitrant history of a rapid radiation. [Gypsum endemism; Oenothera sect. Calylophus; Onagraceae; phylogenomics; pollinator shift; recent radiation; target enrichment.]