bluuebunny/crossref_metadata_2025_split huggingface dataset:
Certification as dysplasia unit and its impact on large loop electrosurgical excision (LEEP)
Authors: Hanczuk Tatjana , Weiss Martin , Henes Leon , Engler Tobias , Neis Felix , Henes Melanie 
Published: October 2022

Abstract
Purpose
This study evaluates the overall treatment indicators and outcomes of patients who underwent loop electrosurgical excision procedure (LEEP) at the Department of Women’s Health Tübingen and the impact of certification as a dysplasia unit on treatment quality.

Methods
Retrospective data analysis of 1596 patients from 2013 to 2018 who underwent LEEP excision at the Department of Women’s Health Tübingen. Data of cytology, colposcopy, biopsy, LEEP histology, repeat LEEP histology and general characteristics were collected and analyzed descriptively.

Results
85.4% (1364) of patients had CIN 2 + and 14.6% (232) had CIN 1 or normal findings on LEEP histology. The proportion of CIN 2 + excisions increased significantly from 82.4% in 2013 to 89% in 2018. The concordance of HSIL biopsy and LEEP histology was 89.1% in 2013 and 92.6% in 2018. In 2018, more biopsies and colposcopies were performed before excision. Complete resection (R0) was achieved in 88.3% of all excisions. R0 rates in patients with CIN 3 increased in 2014–2017 compared to 2013, resulting in fewer Re-LEEP excisions and hysterectomies.

Conclusion
Certification as a dysplasia unit and the associated requirements have improved the diagnostic quality for patients with cervical dysplasia undergoing LEEP. This was demonstrated by several treatment indicators such as the number of colposcopies and biopsies and treatment outcomes such as an increased proportion of CIN 2 + excisions and R0 resections.
Is endolymphatic sac surgery an efficient treatment of Menière's disease patients? A systematic literature search and meta-analysis
Authors: Szott Franziska A. , Westhofen M. , Hackenberg S. 
Published: October 2022

Abstract
Purpose
The purpose of this work is to assess the treatment efficiency of endolymphatic sac surgery in patients with Menière's disease.

Methods
This study provides a systematic literature review and meta-analysis based on the guidelines of the Cochrane Collaboration and the Preferred Reporting Items for Systematic reviews and Meta-Analyses protocol. The main inclusion criteria of the literature review were the classification categories according to the American Academy of Otolaryngology-Head and Neck Surgery guidelines of 1985 and 1995.

Results
An effect of 9.25 dB postoperative weighted average hearing loss in surgically treated individuals is classified as "clinically not significant" according to American Academy of Otolaryngology-Head and Neck Surgery 85/95. In contrast, the deterioration by 26.23% in speech comprehension is considered as "clinically significant." An improvement of functional level scale assessment by two categories and vertigo control by assessment in category B can be observed.

Conclusion
The findings of this meta-analysis indicate that endolymphatic sac surgery may be beneficial as a treatment for Menière's disease in terms of a positive impact on functional level scale and vertigo control while yielding a negative impact on pure tone average hearing loss and on speech comprehension.
Cholesteatoma surgery in the pediatric population: remaining challenges in the era of mastoid obliteration
Authors: Kroon Victor J. , Mes Steven W. , Borggreven Pepijn. A. , van de Langenberg Rick , Colnot David R. , Quak Jasper J. 
Published: October 2022

Abstract
Purpose
To present the first pediatric study on the safety and efficacy of mastoid obliteration using S53P4 bioactive glass (BAG) for cholesteatoma surgery.

Methods
A single-center retrospective cohort study was conducted. Inclusion criteria were pediatric cases (≤ 18 years) and at least at least one year of follow-up including non-echo planar diffusion-weighted MRI to assess cholesteatoma recidivism. Both canal wall up (CWU) and canal wall down (CWD) procedures were evaluated.

Results
A total of 61 cases (56 patients) were included. Most cases had an otologic history before the development of the cholesteatoma. CWU procedure was performed in 18 cases (30%) and CWD procedure in 43 cases (70%). The cholesteatoma recidivism rate was 33% after a mean follow-up period of 58 months. Kaplan–Meier curve estimated a 5-year recidivism rate of 40%. Few complications were seen that were all minor and resolved spontaneously or after local or systemic treatment. Control of the infection (merchant grade 0–1) was achieved in 98% of the cases. Closure of the air–bone gap within 20 dB was achieved in 22% of the cases with complete audiometric evaluation.

Conclusion
In this MRI-controlled study, we show the safety and efficacy of S53P4 BAG for mastoid obliteration in a pediatric cholesteatoma cohort. Postoperative complications were both rare and minor, and a dry ear was achieved in almost all patients. Nevertheless, persistent hearing loss and the apparent high recidivism rate reflect the challenging nature of pediatric cholesteatoma.
Flexible endoscopic evaluation of swallowing in children with type 1 spinal muscular atrophy
Authors: Zang Jana , Johannsen Jessika , Denecke Jonas , Weiss Deike , Koseki Jana-Christiane , Nießen Almut , Müller Frank , Nienstedt Julie Cläre , Flügel Till , Pflug Christina 
Published: October 2022

Abstract
Purpose
This study aimed to report on implementing flexible endoscopic evaluation of swallowing (FEES) in infants and toddlers with type 1 spinal muscular atrophy (SMA). In addition, a comparison of FEES results and clinical scores was carried out.

Methods
A prospective pilot study was conducted including ten symptomatic children with SMA type 1 (two SMN2 copies). They started treatment with one of the three currently approved therapies for SMA at a median age of 3.8 months (range 0.7–8.9). FEES was performed according to a standard protocol using Penetration–Aspiration Scale (PAS) and Murray Secretion Scale as a primary outcome. The Children's Hospital of Philadelphia Infant Test of Neuromuscular Disorders (CHOP-INTEND) for motor function, Neuromuscular Disease Swallowing Status Scale (NdSSS), Oral and Swallowing Abilities Tool (OrSAT), and single clinical swallowing-related parameters were also assessed.

Results
Distinct swallowing disorders were already evident in eight children at inclusion. The most common findings from FEES were pharyngeal secretion pooling, penetration, and aspiration of saliva and food as well as delayed initiation of swallowing. Despite an average increase in motor function, no comparable improvement was found in swallowing function. None of the surveyed clinical scores showed a significant dependence on PAS in a mixed linear model.

Conclusions
Valuable information regarding the status of dysphagia can be gathered endoscopically, particularly concerning secretion management and when oral intake is limited. Currently available clinical tools for children with type 1 may represent a change in nutritional status but are not yet mature enough to conclude swallowing ability. Further development is still required.
Do I care for you or for me? Processing of protected and non-protected moral values in subjects with extreme scores on the Dark Triad
Authors: Ueltzhöffer Kai , Roth Corinna , Neukel Corinne , Bertsch Katja , Nüssel Friederike , Herpertz Sabine C. 
Published: October 2022

AbstractProtected moral values facilitate empathic concern for others, who are exposed to an existential threat, so that one spontaneously helps without taking into account utilitarian cost–benefit considerations. Subjects scoring high on the “Dark Triad” machiavellism, psychopathy, and narcissism are prone to ignore such appeals for selfless help. Until now, data on moral processing and moral decision-making following requests for altruistic help, which directly contrast appeals to protected and non-protected values in subjects with high and low scores on Dark Triad traits, have been missing. In this pilot study 25 healthy subjects with high and 27 with low Dark Triad scores participated in this functional magnetic resonance imaging study. We used a script-driven imagery paradigm to directly contrast requests for selfless help appealing to protected versus non-protected, negotiable moral values. Appeals to protected versus non-protected moral values elicited stronger activations in a large network including insula, amygdala, supramarginal gyrus, and dorsolateral prefrontal cortex. Non-protected values evoked stronger activation in superior frontal sulcus, occipito-temporal junction, and posterior cingulate cortex. During decision-making, high-scorers on the Dark Triad showed increased activations in the superior parietal lobule, precuneus, and intraparietal sulcus. Behaviorally, protected versus non-protected values strongly reduced the reliance on personal cost–benefit calculations in low-scorers, while high-scorers continued to rely on utilitarian deliberations. Data suggest that appeals to protected versus non-protected values activate distinct brain regions associated with strong moral emotions, other-directed cognition, and rule-based decision-making processes. High-scorers display an increased reliance on cost–benefit calculations, which persists even when protected values are threatened.
A systematic review of local field potential physiomarkers in Parkinson’s disease: from clinical correlations to adaptive deep brain stimulation algorithms
Authors: van Wijk Bernadette C. M. , de Bie Rob M. A. , Beudel Martijn 
Published: October 2022

AbstractDeep brain stimulation (DBS) treatment has proven effective in suppressing symptoms of rigidity, bradykinesia, and tremor in Parkinson’s disease. Still, patients may suffer from disabling fluctuations in motor and non-motor symptom severity during the day. Conventional DBS treatment consists of continuous stimulation but can potentially be further optimised by adapting stimulation settings to the presence or absence of symptoms through closed-loop control. This critically relies on the use of ‘physiomarkers’ extracted from (neuro)physiological signals. Ideal physiomarkers for adaptive DBS (aDBS) are indicative of symptom severity, detectable in every patient, and technically suitable for implementation. In the last decades, much effort has been put into the detection of local field potential (LFP) physiomarkers and in their use in clinical practice. We conducted a research synthesis of the correlations that have been reported between LFP signal features and one or more specific PD motor symptoms. Features based on the spectral beta band (~ 13 to 30 Hz) explained ~ 17% of individual variability in bradykinesia and rigidity symptom severity. Limitations of beta band oscillations as physiomarker are discussed, and strategies for further improvement of aDBS are explored.
Resilient Level Ancestor, Bottleneck, and Lowest Common Ancestor Queries in Dynamic Trees
Authors: Gualà Luciano , Leucci Stefano , Ziccardi Isabella 
Published: October 2022

AbstractWe study the problem of designing a resilient data structure maintaining a tree under the Faulty-RAM model [Finocchi and Italiano, STOC’04] in which up to $$\delta $$
δ
memory words can be corrupted by an adversary. Our data structure stores a rooted dynamic tree that can be updated via the addition of new leaves, requires linear size, and supports resilient (weighted) level ancestor queries, lowest common ancestor queries, and bottleneck vertex queries in $$O(\delta )$$

O
(
δ
)

worst-case time per operation.
Short-time effects of spa rehabilitation on pain, mood and quality of life among patients with degenerative or post-surgery musculoskeletal disorders
Authors: Maccarone Maria Chiara , Magro Giacomo , Albertin Claudio , Barbetta Giovanni , Barone Salvatore , Castaldelli Camilla , Manica Patrizia , Marcoli Silvia , Mediati Magda , Minuto Domenico , Poli Patrizia , Sigurtà Christian , Raffaetà Gloria , Masiero Stefano 
Published: October 2022

AbstractClinical trials have demonstrated traditional spa therapy effects in musculoskeletal disorders (MSDs). This is the first observational study in Italy aimed at evaluating in real-life the short-time effects of spa rehabilitation on pain, mood and quality of life (QoL) among degenerative or post-surgery MSDs patients. Through the involvement of six Italian spa facilities, 160 patients were enrolled; data from 123 patients were finally analysed. Seventy-nine patients (64.3%) accessed the spa for degenerative MSDs, while 44 (35.8%) had a post-surgical condition. All the patients included in the study underwent 12 sessions of water-based exercise (joint exercises, muscle strengthening, gait training, proprioceptive and balance techniques) conducted in thermal or in warm water pools, six sessions per week, for a period of 2 weeks from March 2019 up to October 2019. A group of 45 patients (36.6%) also received traditional thermal therapies, including 12 mud therapy sessions and 12 thermal baths, six times each week, for 2 weeks. Evaluation before and after the treatment included the Numerical Rating Scale (NRS), the Short Form Health Survey (SF-12) and the EuroQol-5D (EQ-5D). The analysis of the scores reported in the questionnaires after the treatment showed a significant improvement in all the scores evaluated. Comparison between patients that performed water-based exercise protocols alone (group A) and patients that in addition to water exercise performed traditional thermal interventions (group B) showed no statistically significant differences in NRSp, NRSa, NRSm, SF-12 PCS, SF-12 MCS and EQ-5D variations; only NRSa value reduction was lower in group B. Sulphate water was found to be associated with a lower reduction of all the scores considered, when compared to the other water types. Patients with degenerative or post-surgery MSDs showed favourable effects on pain, mood and QoL after water exercise training alone or in combination with traditional thermal therapy. Our research provides the first proof that spa rehabilitation can be in real-life conditions an appropriate alternative strategy for post-orthopaedic surgical outcomes recovery. In the future, these results will need to be further investigated.
$${\mathscr {A}}$$-quasiconvexity and partial regularity
Authors: Conti Sergio , Gmeineder Franz 
Published: October 2022

AbstractWe establish the first partial regularity result for local minima of strongly $${\mathscr {A}}$$
A
-quasiconvex integrals in the case where the differential operator $${\mathscr {A}}$$
A
possesses an elliptic potential $${\mathbb {A}}$$
A
. As the main ingredient, the proof works by reduction to the partial regularity for full gradient functionals. Specialising to particular differential operators, the results in this paper thereby equally yield novel partial regularity theorems in the cases of the trace-free symmetric gradient, the exterior derivative or the div-curl-operator.
Positive lifestyle behaviours and emotional health factors are associated with low back pain resilience
Authors: Roberts K. E. , Beckenkamp P. R. , Ferreira M. L. , Duncan G. E. , Calais-Ferreira L. , Gatt J. M. , Ferreira P. 
Published: October 2022

Abstract
Purpose
To evaluate the relationship between lifestyle behaviours, emotional health factors, and low back pain (LBP) resilience.

Methods
This retrospective longitudinal study utilised 1,065 twins with a recent history of LBP from the Washington State Twin Registry. A lifestyle behaviour score was built using variables of body mass index, physical activity engagement, sleep quality, smoking status, and alcohol consumption. An emotional health score was built using variables of the absence of depressed mood, perceived stress, and active coping. The main outcome was LBP resilience, assessed as recovery (“bouncing back”), and sustainability (maintaining high levels of function despite LBP).

Results
After adjusting for covariates, there was no relationship between the lifestyle behaviour score (OR 1.05, 95% CI 0.97–1.15, p = 0.218) and the emotional health score (OR 1.08, 95% CI 0.98–1.19, p = 0.142) with the likelihood of recovering from LBP. There was however, evidence of a positive association between the lifestyle behaviour score (β 0.20, 95% CI 0.04–0.36, p = 0.013), the emotional health score (β 0.22, 95% CI 0.00–0.43, p = 0.049), and greater levels of sustainability. These results were confirmed by a within-pair analysis (lifestyle behaviour score: β 1.79, 95% CI 0.05–3.53, p = 0.043) and (emotional health score: β 0.52, 95% CI 0.09–0.96, p = 0.021) adjusting for genetic and early shared environmental confounding.

Conclusion
Findings from this study suggest that people who adopt optimal lifestyle behaviours and positive emotional factors are more likely to be resilient and maintain high levels of function despite suffering from LBP.
Imaging of traumatic mandibular fractures in young adults using CT-like MRI: a feasibility study
Authors: Feuerriegel Georg C. , Ritschl Lucas M. , Sollmann Nico , Palla Benjamin , Leonhardt Yannik , Maier Lisa , Gassert Florian T. , Karampinos Dimitrios C. , Makowski Marcus R. , Zimmer Claus , Wolff Klaus-Dietrich , Probst Monika , Fichter Andreas M. , Burian Egon 
Published: October 2022

Abstract
Objectives
To assess and compare the diagnostic performance of CT-like images based on a three- dimensional (3D) T1-weighted spoiled gradient-echo sequence (3D T1 GRE) with CT in patients with acute traumatic fractures of the mandible.

Materials and methods
Subjects with acute mandibular fractures diagnosed on conventional CT were prospectively recruited and received an additional 3 T MRI with a CT-like 3D T1 GRE sequence. The images were assessed by two radiologists with regard to fracture localization, degree of dislocation, and number of fragments. Bone to soft tissue contrast, diagnostic confidence, artifacts, and overall image quality were rated using a five-point Likert-scale. Agreement of measurements was assessed using an independent t-test.

Results
Fourteen subjects and 22 fracture sites were included (26 ± 3.9 years; 4 females, 10 males). All traumatic fractures were accurately detected on CT-like MRI (n = 22, κ 1.00 (95% CI 1.00–1.00)). There was no statistically significant difference in the assessment of the fracture dislocation (axial mean difference (MD) 0.06 mm, p = 0.93, coronal MD, 0.08 mm, p = 0.89 and sagittal MD, 0.04 mm, p = 0.96). The agreement for the fracture classification as well as the inter- and intra-rater agreement was excellent (range κ 0.92–0.98 (95% CI 0.96–0.99)).

Conclusion
Assessment of mandibular fractures was feasible and accurate using CT-like MRI based on a 3D T1 GRE sequence and is comparable to conventional CT.

Clinical relevance
For the assessment of acute mandibular fractures, CT-like MRI might become a useful alternative to CT in order to reduce radiation exposure particularly in young patients.
Prefecture-specific prevalence of overweight/obesity is associated with regional variation in the incidence of treated ESKD in Japan
Authors: Wakasugi Minako , Narita Ichiei 
Published: October 2022

Abstract
Background
Overweight/obesity is a significant risk factor for chronic kidney disease and end-stage kidney disease (ESKD) in the general population. This study evaluated the impact of sex- and prefecture-specific prevalence of overweight/obesity on standardized incidence rates (SIRs) of treated ESKD in Japan.

Methods
We conducted an ecological study of all prefectures in Japan (n = 47) using data from the Japanese Society of Dialysis Therapy, national census, the NDB Open Data, and the Statistics of Physicians, Dentists and Pharmacists. We calculated the prevalence of overweight/obesity and proteinuria, standardized mortality ratio, and ratio of nephrology specialists for each prefecture, and explored associations of these variables with sex- and prefecture-specific SIRs of treated ESKD using bivariate association analysis, multiple regression analysis, and structural equation modeling (SEM).

Results
Prefecture-specific SIRs ranged from 0.72 to 1.24 for men and 0.69–1.41 for women. Prefecture-specific SIRs were significantly correlated with both the prevalence of overweight/obesity and prevalence of proteinuria. The prevalence of overweight/obesity showed direct, positive, and significant associations with prefecture-specific SIRs in men (standardized estimate (β) = 0.43, p < 0.001) and women (β = 0.40, p < 0.001). The prevalence of proteinuria showed a significant association with prefecture-specific SIRs only in women (β = 0.33, p = 0.01). The SEM models explained 26% of the variance in SIR for men and 28% for women.

Conclusions
Our findings provide evidence that the prefecture-specific prevalence of overweight/obesity in Japan can explain regional variation in prefecture-specific SIRs of treated ESKD in both sexes.
Seismic fragility assessment of bridges with as-built and retrofitted splice-deficient columns
Authors: Opabola Eyitayo A. , Mangalathu Sujith 
Published: October 2022

AbstractA significant proportion of existing bridges in high seismic regions were constructed prior to the 1970s. As a result of poor reinforcement detailing, pre-1970s bridge columns are susceptible to lap-splice or shear failure in the plastic region. Given the high economic impact of retrofitting all pre-1970s reinforced concrete (RC) bridges, it is essential to identify the most vulnerable bridges for retrofit prioritisation. Analytical fragility functions are useful for quantifying the seismic vulnerability of existing bridge stock. However, the accuracy of these fragility functions relies on the adequacy of the adopted modelling approach. This paper presents a hinge-type modelling approach for capturing the seismic response of as-built splice-deficient and retrofitted RC bridge columns. Fragility analysis is carried out for typical seat and diaphragm abutment two-span bridges using the proposed hinge-type modelling approach. The results showed that the vulnerability of the bridges depends on the column failure mode and the limit state under consideration. Also, the common notion that the column is the most vulnerable component may not necessarily be true. The study underscored that retrofitting columns without retrofitting other components may not effectively mitigate the damage and associated risk.
Effect of damping model and inelastic deformation on the prediction of vertical seismic acceleration demand on steel frames
Authors: Gremer Nadia , Adam Christoph , Furtmüller Thomas 
Published: October 2022

AbstractThis study addresses the modeling of different energy dissipation mechanisms for numerical prediction of the vertical acceleration demand in regular moment-resisting steel frame structures. One of the issues discussed is the consideration of viscous damping in the structural model. It is shown that well-established Rayleigh-damping may highly overestimate the damping of the vertical modes, resulting in much too low vertical acceleration response predictions. A study with different damping models provides an appropriate damping modeling strategy that leads to reasonable predictions of both horizontal and vertical frame acceleration demands. Another open question is the effect of inelastic material behavior on the vertical acceleration demand on the considered regular structures. The results of a shell model of a frame structure exposed to high intensity ground motion excitation demonstrate that inelastic material behavior has virtually no impact on the vertical acceleration demand, while structural inelasticity leaves the horizontal acceleration response significantly smaller compared to the elastic demand. This leads to the conclusion that common frame models that capture the inelastic horizontal response but behave elastic in the vertical direction are suitable for the computation of both the horizontal and vertical acceleration demand.