bluuebunny/crossref_metadata_2025_split huggingface dataset:
Experimental Study of the Efficacy and Safety of a New PEG-Based Laxative
Authors: Shekunova E. V. , Mazukina E. V. , Vavilova V. A. , Kashkin V. V. , Balabanyan V. Yu. , Fazylov M. F. , Makarova M. N. , Makarov V. G. 
Published: July 2022

Bowel-cleansing PEG-based agents, including Moviprep®, are commonly used to prepare the large intestine for diagnostic examinations. PLNV-next is a newly developed fixed combination medicinal product with a composition similar to that of Moviprep®.The aim of the study was to estimate the pharmacological efficacy and toxicity of PLNV-next.Materials and methods: The study evaluated pharmacological efficacy of four formulations of PLNV-next in comparison with Moviprep® after a single administration in a therapeutic dose to outbred rats. The evaluation was carried out based on the laxative effect of the medicinal products. The authors recorded diarrhoea onset latency and the number of defecation boluses and diarrhoea spots produced during the 6-hour observation period. Toxicity of PLNV-next was studied in the formulation containing maximum amounts of the ingredients according to the patent. In the single-dose toxicity study, PLNV-next was administered intragastrically to rats at doses of 4.2 g/kg (maximum human therapeutic dose, MHTD), 21 g/kg (5 MHTD), and 42 g/kg (10 MHTD) and to ferrets at doses of 4.2 g/kg (MHTD) and 21 g/kg (5 MHTD). In the repeated-dose toxicity study, PLNV-next was administered for 14 days at 4.2 g/kg (rats and ferrets), 21 g/kg (5 MHTD, rats), and 12.6 g/kg (3 MHTD, ferrets). Additionally, the repeated-dose toxicity study evaluated safety pharmacology parameters for the cardio-vascular, respiratory and central nervous systems.Results: All PLNV-next formulations tested exerted a laxative effect equivalent to that of Moviprep®. No clinical signs of toxicity were observed in rats, with the exception of the laxative effect. Ferrets demonstrated decreased behavioral activity and diarrhoea. Nausea or emesis were noted in 75–90% of the ferrets receiving the doses exceeding the MHTD. A single administration of PLNV-next affected blood sodium concentrations: a slight increase was noted in the 5 MHTD and 10 MHTD groups of rats and in the 5 MHTD group of ferrets. The repeated-dose toxicity study in rats revealed a slight increase in sodium levels with both test doses. After a single administration of 5 MHTD to ferrets, the authors observed a decrease in potassium levels. All the changes were mild and within physiological ranges. PLNV-next toxic effects observed in the rat and ferret studies were similar to those reported in rat and dog toxicity studies of Moviprep®. Conclusion: PLNV-next exerts a marked laxative effect and has a favourable safety profile.
EDITORIAL DEL VOL. 14 INVESTIGACION Y DESARROLLO I+D Enero-Junio 2021
Authors: Valdez Duffau(PhD) Mathias , (PhD) Yenddy Carrero , (PhD) Alicia Zavala 
Published: July 2022

John Paúl Reyes Vasquez (Mg)- Director Dirección de Investigación y Desarollo, UTA

Mathias Exequiel Valdez Duffau(PhD)-Editor - Revista Investigación y Desarrollo, UTA

Yenddy Carrero Castillo -Coordinadora Volumen 14

Alicia Marifernanda Zavala Calahorrano-Asistente editorial

Revista de Divulgación Científica
INVESTIGACIÓN Y DESARROLLO I+D
Volúmen 14, Número 1
P-ISSN: 1390-5546
E-ISSN: 2361-2557
revista.dide@uta.edu.ec
Publicado: 2021-07-31
EXTRACTOS DE PLANTAS MICROENCAPSULADAS CON POTENCIAL ACTIVIDAD ANTIVIRAL: UNA REVISION GENERAL
Authors: Rodriguez Conterón Oscar , López Hernández Orestes 
Published: July 2022

El uso de compuestos activos de plantas ha generado una alternativa natural en torno a las afecciones que involucran la salud humana. Un extracto de plantas es una mezcla compleja de moléculas bioactivas que presenta propiedad antioxidante, antiviral, antimicrobiana, antiparasitaria, entre otras. A pesar que un reto prominente para el uso de extractos herbales es el uso de solventes orgánicos pues dificultan su formulación y administración directa a personas, esto podría ser solucionado ya que investigaciones recientes señalan a la microencapsulación como una tecnología alentadora en la administración de fitofármacos.
La presente revisión se centró en treinta y dos estudios publicados en idioma Inglés y Español de algunas investigaciones relevantes realizadas mayoritariamente en los últimos diez años que señalaron la importancia de las plantas en el área farmacéutica, principios activos de plantas con actividad antiviral, formulaciones de extractos de plantas, además del uso de la microencapsulación para su presentación final y aseguramiento en su biodisponibilidad, proporcionando una descripción general en la investigación global sobre el secado de extractos herbales con potencial actividad antiviral.
Viva l’Italia: Carducci, uno strano Nobel
Authors: Scarsella Alessandro 
Published: July 2022

Si ricostruisce l'atmosfera che accompagnònel 1906 il conferimento del Premio Nobel per la letteratura a Giosue Carducci, sottolinenandone l'anacronsmo e le motivazioni esplicitamente nazionalistiche e sotterraneamente antiasburgiche. Tuttavia, la ricezione novecentesca di Carducci, da Croce fino alle soglie del 1968 continuerà a ribadirne la priorità nel canone della poesia italiana moderna.
Prawiek i inne czasy Olgi Tokarczuk w perspektywie lingwistyki kulturowej i ekologicznej
Authors: Sławek Ewa 
Published: July 2022

Autorka podejmuje próbę odczytania powieści Olgi Tokarczuk Prawiek i inne czasy przez pryzmat kategorii i pojęć współczesnej lingwistyki kulturowej (etnolingwistyki) i ekologicznej, takich jak językowy obraz świata, stereotyp, mapa mentalna, leksykalny ekosystem. Analiza języka utworu za pomocą instrumentarium lingwistyki kulturowej pozwoliła na sformułowanie przekonania, że noblistka stworzyła w tym utworze historyczno-kulturowy i społeczny „portret” tej części Europy Środkowej, która nazywa się Polska prowincjonalna. Jej zdaniem obraz ten składa się pewnego systemu prawd, mitów i nierzadko fałszywych wyobrażeń. Nie podejmując sporu z zespołem obecnych w naszej kulturze i mentalności stereotypów (np. etnicznych), mitów i przeświadczeń, pisarka wskazała na siłę oddziaływania powielanych nadal klisz myślowych. Natomiast narzędzia badawcze lingwistyki ekologicznej pozwoliły dostrzec w powieści polemikę z tradycją humanistyki antroponormatywnej i określić postawę autorki jako proekologiczną.
Pengaruh Kesadaran Merek, Citra Merek, Status Pionir terhadap Minat Beli Jasa Reservasi Hotel Online
Authors: Hadinata Denda Rinaldi , Haryanti Sri 
Published: July 2022

Situasi pandemi saat ini menjadikan masyarakat memiliki allternatif lain untuk berwisata yaitu dengan cara staycation. Ketertarikan masyarakat untuk staycation menjadikan penyedia jasa reservasi hotel online sangat dibutuhkan untuk memesan kamar hotel dengan cepat dibandingkan harus pergi ke hotel terlebih dahulu. Penyedia jasa reservasi hotel online dengan merek Traveloka berhasil memimpin pasar dan berhasil mengenalkan mereknya dengan sukses kepada masyarakat luas. Namun di sisi lain Traveloka bukanlah merek pionir penyedia jasa reservasi hotel online yang pertama kali muncul di Indonesia, melainkan Tiket.com. Walaupun Tiket.com merupakan merek pionir namun kenyataannya pengetahuan konsumen akan keberadaan merek pionir masih rendah. Sehingga peneliti tertarik untuk meneliti pengaruh kesadaran merek, citra merek dan status merek pionir terhadap minat beli konsumen jasa reservasi hotel online di Kota Bogor. Analisin pada peneltian ini menggunakan Structural Equation Modeling dengan menggunakan smartPLS 3.0. Hasil penelitian menunjukan bahwa Tiket.com memiliki empat pengaruh yang positif signifikan antar variabelnya antara lain kesadaran merek yang mempengaruhi citra merek, citra merek yang mempengaruhi status merek pionir, kesadaran merek yang mempengaruhi minat beli konsumen, dan status merek pioner yang mempengaruhi minat beli konsumen. Namun, hanya satu yang tidak memberikan pengaruh yang tidak signifikan yaitu citra merek terhadap minat beli konsumen.
Augmented reality–assisted microsurgical resection of brain arteriovenous malformations: illustrative case
Authors: Scherschinski Lea , McNeill Ian T. , Schlachter Leslie , Shuman William H. , Oemke Holly , Yaeger Kurt A. , Bederson Joshua B. 
Published: July 2022

BACKGROUND
Arteriovenous malformations (AVMs) of the brain are vessel conglomerates of feeding arteries and draining veins that carry a risk of spontaneous and intraoperative rupture. Augmented reality (AR)-assisted neuronavigation permits continuous, real-time, updated visualization of navigation information through a heads-up display, thereby potentially improving the safety of surgical resection of AVMs.

OBSERVATIONS
The authors report a case of a 37-year-old female presenting with a 2-year history of recurrent falls due to intermittent right-sided weakness and increasing clumsiness in the right upper extremity. Magnetic resonance imaging, magnetic resonance angiography, and cerebral angiography of the brain revealed a left parietal Spetzler-Martin grade III AVM. After endovascular embolization of the AVM, microsurgical resection using an AR-assisted neuronavigation system was performed. Postoperative angiography confirmed complete obliteration of arteriovenous shunting. The postsurgical course was unremarkable, and the patient remains in excellent health.

LESSONS
Our case describes the operative setup and intraoperative employment of AR-assisted neuronavigation for AVM resection. Application of this technology may improve workflow and enhance patient safety.
Compressive optic neuropathy caused by a flow-diverter-occluded-but-still-growing supraclinoid internal carotid aneurysm: illustrative case
Authors: Tsuei Yuang-Seng , Fu Yun-Yen , Chen Wen-Hsien , Cheng Wen-Yu , Liao Chih-Hsiang , Shen Chiung-Chyi 
Published: July 2022

BACKGROUND
Flow diverter stenting is an effective treatment for large proximal internal carotid artery (ICA) aneurysms. Cranial neuropathy caused by the mass effect of the aneurysm usually subsides over time. However, a new onset of compressive optic neuropathy after successful flow diverter stenting of a large proximal ICA aneurysm is seldom reported.

OBSERVATIONS
A 57-year-old woman had a right supraclinoid ICA aneurysm (approximately 17 mm) on magnetic resonance angiography (MRA) in a health checkup. She received intervention with the Pipeline embolization device. Six months later, she started to experience progressive hemianopia in the left half of the visual field. Nine months after stenting, MRA showed that the aneurysm was growing and causing mass effect, but digital subtraction angiography confirmed that the aneurysm was completely excluded from the circulation. She received a craniotomy for microsurgical decompression of the optic nerve and coagulation shrinkage of the aneurysm. Clipping and thrombectomy were not attempted. Her visual fields recovered gradually. Follow-up MRA showed that the aneurysm also diminished in size.

LESSONS
Whether the coagulation technique of the flow-diverter-occluded aneurysm alone is enough to cause satisfactory shrinkage and interaction between the flow diverter and the aneurysmal vasa vasorum/neointima formation should be further examined.
Endoscopic endonasal approaches for reconstruction of traumatic anterior skull base fractures and associated cerebrospinal fistulas: patient series
Authors: Sheth Megha K. , Strickland Ben A. , Chung Lawrance K. , Briggs Robert G. , Weiss Martin , Wrobel Bozena , Zada Gabriel 
Published: July 2022

BACKGROUND
Post-traumatic cerebrospinal fluid (CSF) leaks of the anterior skull base may arise after traumatic brain injury (TBI). Onset of CSF rhinorrhea may be delayed after TBI and without prompt treatment may result in debilitating consequences. Operative repair of CSF leaks caused by anterior skull base fractures may be performed via open craniotomy or endoscopic endonasal approaches (EEAs). The authors’ objective was to review their institutional experience after EEA for repair of TBI-related anterior skull base defects and CSF leaks.

OBSERVATIONS
A retrospective review of prospectively collected data from a major level 1 trauma center was performed to identify patients with TBI who developed CSF rhinorrhea. Persistent or refractory post-traumatic CSF leaks and anterior skull base defects were repaired via EEA in four patients. Intrathecal fluorescein was administered before EEA in three patients (75%) to help aid identification of the fistula site(s). CSF leaks were eventually repaired in all patients, though one reoperation was required. During a mean follow-up of 8.75 months, there were no instances of recurrent CSF leakage.

LESSONS
Refractory, traumatic CSF leaks may be effectively repaired via EEA using a multilayer approach and nasoseptal flap reconstruction, thereby potentially obviating the need for additional craniotomy in the post-TBI setting.
Primary spinal infections in patients with solid organ transplant: a systematic literature review and illustrative case
Authors: Hatter Matthew J. , Beyer Ryan S. , Camino-Willhuber Gaston , Franklin Austin , Brown Nolan J. , Hashmi Sohaib , Oh Michael , Bhatia Nitin , Lee Yu-Po 
Published: July 2022

BACKGROUND
Primary spinal infections (PSIs) are a group of uncommon but serious infectious diseases considered more prevalent and aggressive among patients with chronic immunocompromised states. Association of PSI and solid organ transplant has not been systematically analyzed. The authors performed a systematic review analyzing clinical presentation and mortality of patients with PSI in the setting of solid organ transplant.

OBSERVATIONS
PSIs in patients with immunosuppressive therapy, such as those with solid organ transplant, may behave differently in terms of epidemiology, clinical presentation, and outcomes compared with nonimmunosuppressed patients. Overall PSI in solid organ transplant patients is associated with a high rate of neurological compromise, postoperative complications, and mortality.

LESSONS
Accurate diagnosis and appropriate treatment of PSI require a multidisciplinary effort. Localized pain is the most frequently reported symptom associated with PSI. As opposed to PSI in patients without transplant, inflammatory and infectious markers such as white blood cells and C-reactive protein are often not elevated. Furthermore, the causative microorganism profile varies significantly when compared to pyogenic spinal infection in patients without transplant. Aspergillus species was responsible for spondylodiscitis in transplant patients in more than 50% of cases, and the incidence of Aspergillus infection is projected to rise in the coming years.
Nonconvulsive status epilepticus due to pneumocephalus after suprasellar arachnoid cyst fenestration with transsphenoidal surgery: illustrative case
Authors: Kagami Yohei , Saito Ryu , Kawataki Tomoyuki , Ogiwara Masakazu , Hanihara Mitsuto , Kazama Hirofumi , Kinouchi Hiroyuki 
Published: July 2022

BACKGROUND
Nonconvulsive status epilepticus (NCSE) requires prompt diagnosis and treatment, particularly after neurosurgical procedures for cerebral damage. Here, the authors reported an extremely rare case of suprasellar arachnoid cyst presenting with NCSE after cyst fenestration with transsphenoidal surgery, which was associated with pneumocephalus.

OBSERVATIONS
A 61-year-old man presented with visual impairment and was diagnosed with a suprasellar arachnoid cyst on magnetic resonance imaging (MRI). The patient received cyst fenestration with endonasal transsphenoidal surgery. His visual symptoms improved immediately after the operation; however, on postoperative day 3, semicoma appeared and was prolonged. The patient was diagnosed with NCSE due to pneumocephalus based on MRI and electroencephalography (EEG) findings. The administration of antiepileptic drugs (AEDs) improved his clinical symptoms and the abnormal findings on MRI and EEG.

LESSONS
This is the first case of NCSE with pneumocephalus after transsphenoidal surgery for a suprasellar arachnoid cyst. Pneumocephalus due to cerebrospinal fluid leakage can cause NCSE. Arterial spin labeling perfusion imaging and diffusion-weighted imaging are as useful for differentially diagnosing NCSE as EEG and AED tests.
Research work of masters’ students in the context of a digitalized dialogue of cultures
Authors:   Bunin Yelets State University, Dvoryatkina Svetlana N. , Dyakina Angelica A. ,   Bunin Yelets State University, Shcherbatykh Sergey V. ,   Bunin Yelets State University
Published: July 2022

Introduction. The relevance of the research is determined by the need to identify the possibilities of mutually enriching dialogue of philological and mathematical knowledge in the digital space in the implementation of research work of undergraduates. The purpose of the article is to find ways to improve organizational and methodological tools for the development of research skills of future philologists. In this regard, the authors propose their own concept and specific ways to solve the problem, which consist in supplementing the list of professional competencies in the field of research and development. Materials and methods. Assessment of the formation of research competencies of undergraduates in the process of solving interdisciplinary tasks in a network format was carried out on the control (n1=20) and experimental (n2=20) Diagnostics was carried out on the basis of monitoring the actual results of the activity of research activities of undergraduates. The empirical results of the study were analyzed using a set of mathematical and statistical methods (methods of descriptive statistics φ*-test Fisher). The results of the study. The organization of a communication space for program participants is carried out through the creation of web sites where managers pose professional problems to undergraduates in the humanities, and students of other profiles provide technical or mathematical assistance in solving them with further critical discussion and evaluation of the results obtained. The study illustrates interdisciplinary tasks for philology students based on computer modeling methods and textual analysis. Diagnostics of the formation of research competencies proved the statistical significance of the proposed content and forms of training (φ emp* =2,58 in terms of academic performance of research and φemp* =2,353 in terms of research activity). Conclusion. The innovative methodology of organizing research of undergraduates in a network format, implemented at Bunin Yelets State University, is effective for various humanitarian areas of training. The actions of undergraduates associated with the formulation, modeling and interpretation of data demonstrate the formation of competencies that reflect key types of research activities in solving professional problems based on the dialogue of cultures.
PENGEMBANGAN E-MODUL SCREENCAST BERBASIS STEM PADA MATERI REPRODUKSI DI PONDOK PESANTREN AS-SAIDYAH 1
Authors: Meishanti Ospa Pea Yuanita , Chasanah Binti Wasiatul 
Published: July 2022

ABSTRACT
Problems in the field regarding ongoing learning are still not conducive at As-Saidyah 1 pesantren, especially at the level of understanding and discussion forums for rear-row audiences are difficult to ask questions. The difficulty of understanding in the field of menstruation, especially on the problem of calculation, which requires formulas that must be studied. So this study developed a STEM-based Screencast e-module on reproductive system material with the aim of finding out the feasibility of media and material from developing e-modules which can then be applied in the pesantren with the contents of the e-module in the form of material, e-lks based on the method of calculating the period of menstruation, by using the ADDIE development model and getting the results of 80% media eligibility with proper criteria and material feasibility with a percentage of 84% very feasible criteria. So it can be concluded that the media can be developed and implemented in Pesantren As-Saidyah 1.
KEYWORDS: e-module, Screencast, STEM

ABSTRAK
Permasalahan dilapang mengenai pembelajaran berjalan masih kurang kondusif di pesantren As-Saidyah 1, terutama pada tingkat pemahaman dan forum diskusi tanya jawab audien barisan belakang sulit untuk bertanya. Sulitnya pemahaman di bidang menstruasi terutama pada masalah perhitungan, yang mana membutuhkan rumus-rumus yang harus dikaji. Maka penelitian ini mengembangkan e-modul Screencast berbasis STEM pada materi sistem reproduksi dengan tujuan menetahui kelayakan media dan materi dari pengembangan e-modul kemudian dapat diterapkan di pesantren tersebut dengan isi e-modul berupa materi, e-lks yang berbasis cara perhitungan masa mentruasi, dengan menggunakan model pengembangan ADDIE dan mendapatkan hasil kelayakan media 80 % dengan kriteria layak dan kelayakan materi dengan prosentase 84 % kriteria sangat layak. Sehingga dapat simpulkan bahwa media dapat dikembangkan dan di implementasikan di Pesantren As-Saidyah 1.
KATA KUNCI: E-modul, Screencast, STEM
The Queer Transnational in Kate O’Brien and Elizabeth Bowen
Authors: Murphy Naoise 
Published: July 2022

Transnational modes of thought play a constitutive role in the imaginary of Irish queerness. The novels of Elizabeth Bowen and Kate O'Brien offer a dualistic contestation of hegemonic sex/gender conventions that can be theorised as ‘the queer transnational.’ Based on sustained engagement with the thematics of abjection, their writing highlights how the transnational is deeply embedded in the structure of queer imaginaries in Irish writing. Through readings of O’Brien’s novels Mary Lavelle (1936) and The Land of Spices (1942), and Bowen’s The Last September (1929) and Eva Trout (1968), this article proposes ‘the queer transnational’ as a new way of thinking about queer literary histories in the formative years of the modern Irish State.

Keywords: Queer; Transnational; Irish Literature; Elizabeth Bowen; Kate O’Brien; Abjection; Twentieth Century