bluuebunny/crossref_metadata_2025_split huggingface dataset:
The influence of price location on reference-price ads
Authors: Cheng Yin-Hui , Chuang Shih-Chieh , Lee Chao-Feng , Kao Chiao-Ying 
Published: August 2022

PurposeResearch has shown that when the original and the sale prices were displayed in a horizontal direction, with the sale price to the right (“Original price of $349.99/Sale price $239.99”), consumers are more likely to initiate a subtraction task to calculate the amount of the discount; and this subtraction effect would lead to better consumer value perception than if the sale price was to the left. However, fewer scholars have questioned whether the subtraction effect would still operate if the reference-price ads line up in a vertical direction? The aim of this research is to understand how different formations of reference-price ads may affect consumers' price perception and buying intention. Interestingly, positive effects on buying intention and value perceptions disappeared when buyers were shown a dollars-saved cue, rather than the lineup of original and sale prices.Design/methodology/approachThree experiments were conducted to test the hypotheses.FindingsThe results of the experiments demonstrate that when the sale price is displayed above the original price, consumers' price perception and buying intention are higher than what is placed below it.Research limitations/implicationsWhen written horizontally, Mandarin and Japanese language text are almost always written left-to-right, with multiple rows progressing downward, as in standard English text. Notably, the right-to-left written form for Mandarin and Japanese language only happens by writing in a vertically and multiple-columned context. In particular, the format of reference-price ads in our research is considered to be a generally single column text only. Therefore, its writing system has almost no difference from the English one. However, our hypothesis does not apply to the Arabic world due to the right-to-left nature of the Arabic writing system.Practical implicationsOur results may inform consumers whether their cognition, which influences them not to make irrational decisions, is in turn influenced by sale price display location. Consumers should be reminded that next time they see the smaller number (sale price) they should not be too excited and forget to properly consider the original price. They should think more and consider the distance to the shop or the quality of the product before buying anything. If a product is sold in two different shops and the farther one displays the sale price above the original price but the nearer one displays the sale price below the original price, prolonging the decision time enables consumers to decrease their buying costs, such as the cost of fuel.Originality/valueThis is one of the first studies to discuss the influence of the price location in a vertical direction on price perception and buying intention.
Microbiome of pear psyllids: A tale about closely related species sharing their endosymbionts
Authors: Štarhová Serbina Liliya , Gajski Domagoj , Pafčo Barbora , Zurek Ludek , Malenovský Igor , Nováková Eva , Schuler Hannes , Dittmer Jessica 
Published: August 2022

AbstractPsyllids are phloem‐feeding insects that can transmit plant pathogens such as phytoplasmas, intracellular bacteria causing numerous plant diseases worldwide. Their microbiomes are essential for insect physiology and may also influence the capacity of vectors to transmit pathogens. Using 16S rRNA gene metabarcoding, we compared the microbiomes of three sympatric psyllid species associated with pear trees in Central Europe. All three species are able to transmit ‘Candidatus Phytoplasma pyri’, albeit with different efficiencies. Our results revealed potential relationships between insect biology and microbiome composition that varied during psyllid ontogeny and between generations in Cacopsylla pyri and C. pyricola, as well as between localities in C. pyri. In contrast, no variations related to psyllid life cycle and geography were detected in C. pyrisuga. In addition to the primary endosymbiont Carsonella ruddii, we detected another highly abundant endosymbiont (unclassified Enterobacteriaceae). C. pyri and C. pyricola shared the same taxon of Enterobacteriaceae which is related to endosymbionts harboured by other psyllid species from various families. In contrast, C. pyrisuga carried a different Enterobacteriaceae taxon related to the genus Sodalis. Our study provides new insights into host–symbiont interactions in psyllids and highlights the importance of host biology and geography in shaping microbiome structure.
Passive tolerance and productive uncertainties in food allergy immunotherapy biomedical practices
Authors: Nairn Stephanie A. 
Published: August 2022

AbstractThere has been little sociological research on food allergy in North America, despite the fact that it impacts a significant population in the US and Canada. Immunotherapy for food allergy is now a prominent area of investigation and experts argue it is one dimension of a ‘paradigm shift’ that encourages exposure to food allergens in contrast to avoidance of them. This article reports on an ethnographic investigation of immunotherapy for food allergy research and practice between the years 2015 and 2020. I report on analyses of N = 31 in‐depth interviews with spokespersons with different types of engagement in immunotherapy and over 100 h of ethnographic observations at clinical and scientific conferences. My research revealed the entangled ontologies of food and drug in immunotherapy and related uncertainties in the diagnoses of food allergy, which catalysed further uncertainty about who is receiving and who should receive immunotherapy (IT). Relatedly, there are uncertainties about the goals and/or outcomes of IT. I elaborate on previous sociological work about how uncertainty is valued in medicine and science. I argue shared uncertainties and mutual scepticism in IT co‐exist, representing a passive (productive) tolerance and reticently accepted form of tension in the domain, which have resulted in calls for intra‐professional and inter‐professional collaborations and the involvement of other stakeholders in knowledge making regarding food allergy immunotherapy.
An integrative bioinformatics pipeline shows that honeybee‐associated microbiomes are driven primarily by pollen composition
Authors: Chesters Douglas , Liu Xiuwei , Bell Karen L. , Orr Michael C. , Xie Tingting , Zhou Qingsong , Zhu Chaodong 
Published: August 2022

AbstractThe microbiomes associated with bee nests influence colony health through various mechanisms, although it is not yet clear how honeybee congeners differ in microbiome assembly processes, in particular the degrees to which floral visitations and the environment contribute to different aspects of diversity. We used DNA metabarcoding to sequence bacterial 16S rRNA from honey and stored pollen from nests of 4 honeybee species (Apis cerana, A. dorsata, A. florea, and A. laboriosa) sampled throughout Yunnan, China, a global biodiversity hotspot. We developed a computational pipeline integrating multiple databases for quantifying key facets of diversity, including compositional, taxonomic, phylogenetic, and functional ones. Further, we assessed candidate drivers of observed microbiome dissimilarity, particularly differences in floral visitations, habitat disturbance, and other key environmental variables. Analyses revealed that microbiome alpha diversity was broadly equivalent across the study sites and between bee species, apart from functional diversity which was very low in nests of the reclusive A. laboriosa. Turnover in microbiome composition across Yunnan was driven predominantly by pollen composition. Human disturbance negatively impacted both compositional and phylogenetic alpha diversity of nest microbiomes, but did not correlate with microbial turnover. We herein make progress in understanding microbiome diversity associated with key pollinators in a biodiversity hotspot, and provide a model for the use of a comprehensive informatics framework in assessing pattern and drivers of diversity, which enables the inclusion of explanatory variables both subtly and fundamentally different and enables elucidation of emergent or unexpected drivers.
SCNIC: Sparse correlation network investigation for compositional data
Authors: Shaffer Michael , Thurimella Kumar , Sterrett John D. , Lozupone Catherine A. 
Published: August 2022

AbstractMicrobiome studies are often limited by a lack of statistical power due to small sample sizes and a large number of features. This problem is exacerbated in correlative studies of multi‐omic datasets. Statistical power can be increased by finding and summarizing modules of correlated observations, which is one dimensionality reduction method. Additionally, modules provide biological insight as correlated groups of microbes can have relationships among themselves. To address these challenges, we developed SCNIC: Sparse Cooccurrence Network Investigation for compositional data. SCNIC is open‐source software that can generate correlation networks and detect and summarize modules of highly correlated features. Modules can be formed using either the Louvain Modularity Maximization (LMM) algorithm or a Shared Minimum Distance algorithm (SMD) that we newly describe here and relate to LMM using simulated data. We applied SCNIC to two published datasets and we achieved increased statistical power and identified microbes that not only differed across groups, but also correlated strongly with each other, suggesting shared environmental drivers or cooperative relationships among them. SCNIC provides an easy way to generate correlation networks, identify modules of correlated features and summarize them for downstream statistical analysis. Although SCNIC was designed considering properties of microbiome data, such as compositionality and sparsity, it can be applied to a variety of data types including metabolomics data and used to integrate multiple data types. SCNIC allows for the identification of functional microbial relationships at scale while increasing statistical power through feature reduction.
A gut‐centric view of aging: Do intestinal epithelial cells contribute to age‐associated microbiota changes, inflammaging, and immunosenescence?
Authors: Hohman Leah S. , Osborne Lisa C. 
Published: August 2022

AbstractIntestinal epithelial cells (IECs) serve as both a physical and an antimicrobial barrier against the microbiota, as well as a conduit for signaling between the microbiota and systemic host immunity. As individuals age, the balance between these systems undergoes a myriad of changes due to age‐associated changes to the microbiota, IECs themselves, immunosenescence, and inflammaging. In this review, we discuss emerging data related to age‐associated loss of intestinal barrier integrity and posit that IEC dysfunction may play a central role in propagating age‐associated alterations in microbiota composition and immune homeostasis.
Proportion of suicides in Denmark attributable to bereavement by the suicide of a first‐degree relative or partner: Nested case–control study
Authors: Pitman Alexandra , McDonald Keltie , Logeswaran Yanakan , Lewis Gemma , Cerel Julie , Erlangsen Annette 
Published: August 2022

AbstractObjectiveTo provide the first estimates of the risk of suicide after bereavement by the suicide of any first‐degree relative and the proportion of suicides in Denmark attributable to suicide bereavement.MethodsWe conducted a nationwide nested case–control study defining cases as all Danish‐born individuals who died by suicide in Denmark between 01 January 1980 and 31 December 2016 (n = 32,248), age‐matched to four living controls. Using three exposure categories (bereavement by the suicide of a relative [parent, offspring, sibling, and spouse/cohabitee]; non‐suicide bereavement; no bereavement) and conditional logistic regression adjusted for pre‐specified covariates we estimated the odds of exposure to suicide bereavement in cases versus controls. We tested whether associations differed for men and women, estimated the population attributable fraction (PAF) of suicides in our population at risk that could be attributed to a first‐degree relative's suicide loss, and estimated the attributable fraction among the exposed (AFe).ResultsSuicide bereavement was associated with an increased odds of suicide when compared with no bereavement (ORadj2 = 2.90, 95% CI: 2.46–3.40) or non‐suicide bereavement (ORadj2 = 1.48, 95% CI: 1.25–1.74). There was no evidence to support any interaction with sex. PAF (0.69%; 95% CI: 0.62%–0.77%) and AFe (60.12%; 95% CI: 53.19%–66.03%) estimates suggested that in Denmark 0.69% of suicides, and 60% of suicides among suicide‐bereaved relatives, could be prevented if it was possible to address all factors increasing suicide risk in suicide‐bereaved relatives.ConclusionSuicide bereavement in relatives and partners contributes to at least one in 145 suicides in Denmark.
Multiple‐ascending doses of ACT‐1014‐6470, an oral complement factor 5a receptor 1 (C5a1 receptor) antagonist: Tolerability, pharmacokinetics and target engagement
Authors: Anliker‐Ort Marion , Dingemanse Jasper , Farine Hervé , Groenen Peter , Kornberger Rüdiger , van den Anker John , Kaufmann Priska 
Published: August 2022

AimsTargeting the complement factor 5a receptor 1 (C5a1 receptor) offers potential to treat various autoimmune diseases. The C5a1 receptor antagonist ACT‐1014‐6470 was well tolerated in a single‐ascending dose study in healthy subjects. This double‐blind, randomized, placebo‐controlled study aimed to investigate the safety, tolerability, pharmacokinetics (PK) and target engagement of multiple‐ascending doses of ACT‐1014‐6470.MethodsPer dose level, 10 healthy male and female subjects of nonchildbearing potential (1:1 sex ratio) were enrolled to assess 30, 60 and 120 mg ACT‐1014‐6470 administered twice daily for 4.5 days under fed conditions. Adverse events, clinical laboratory data, vital signs, electrocardiogram and PK blood samples were collected up to 120 h post last dose and ex vivo stimulated matrix metalloproteinase 9 was quantified as target engagement biomarker. At the 60‐mg dose level, PK samples were collected until 8 weeks post last dose.ResultsThe total adverse event number was 57 and no treatment‐related safety pattern was apparent. At steady state, ACT‐1014‐6470 reached maximum plasma concentrations after 2–3 h and the half‐life estimated up to Day 10 was 115–146 h across dose levels. Exposure parameters increased dose‐proportionally, steady state was attained between Day 3–5, and ACT‐1014‐6470 accumulated 2‐fold. At the 60‐mg dose level, ACT‐1014‐6470 was quantifiable until 8 weeks after the last dose. Matrix metalloproteinase 9 release was suppressed to endogenous background concentrations up to the last sampling time point, confirming sustained target engagement of ACT‐1014‐6470.ConclusionThe compound was generally safe and well tolerated at all dose levels, warranting further clinical investigations.
Early signs of functioning and contextual factors in children 0 to 6 years of age at high risk of or with developmental coordination disorder: A scoping review
Authors: González López Anaïs , Crespo Madrid Vanesa , Hidalgo‐Robles Álvaro , Gutiérrez‐Ortega Mónica 
Published: August 2022

AbstractBackgroundDevelopmental coordination disorder (DCD) can significantly impact body structures and functions, activities, participation and contextual factors. Using a scoping review methodology, we aimed to identify the characteristics or signs that can have an early impact on the development and functioning of children with DCD between 0 and 6 years.MethodsWe searched the Medline, Cochrane and PEDro databases. The screening of the 1580 articles obtained was conducted independently and in duplicate. From the included articles, among others, we extracted results that reported the early developmental characteristics of children at high risk or diagnosed with DCD, the components of the International Classification of Functioning (ICF) and the F‐Words studied in the results or the agents involved in the evaluation.ResultsSeventeen articles were included in the review. From them, a set of early signs of DCD—general and specific—were collected that reflected the existence of restrictions in daily life activities from an early age and in certain routines, such as eating, dressing, grooming or playing. The most studied components of the ICF were activities and participation, with functioning being the most studied F‐word.ConclusionsDetection of activity limitations and restrictions in participation between 0 and 6 years in children with DCD is possible. Recognition of parental concerns and early assessment could facilitate the follow‐up of children at high risk for DCD and their inclusion in screening programs that include standardized tools for their diagnosis.
Is childhood oral health the ‘canary in the coal mine’ for poor adult general health? Findings from two New Zealand birth cohort studies
Authors: Ruiz Begoña , Broadbent Jonathan M. , Murray Thomson William , Ramrakha Sandhya , Boden Joseph , Horwood John , Poulton Richie 
Published: August 2022

AbstractObjectivesThis study aimed to investigate whether childhood dental caries was associated with self‐reported general health in midlife.MethodsWe used data on childhood oral health (caries experience) and adult self‐reported general health from two New Zealand longitudinal birth cohorts, the Dunedin Multidisciplinary Health and Development Study (n = 922 and n = 931 at ages 5 and 45 years, respectively), and the Christchurch Health and Development Study (n = 1048 and n = 904 at ages 5 and 40 years, respectively). We used generalized estimating equations to examine associations between age‐5 dental caries and self‐rated general health and the number of self‐reported physical health conditions at ages 45/40 (diagnosed by a doctor or health professional, n = 14 conditions among both cohorts). Covariates included known risk factors for poor health (SES, IQ, perinatal complications), and personality style, which is known to affect subjective health ratings.ResultsIncidence rate ratios for ‘Excellent’ self‐rated health were lower among those who had high experience of dental caries as children than those who had not in both, the Dunedin (IRR, 0.76; 95% CI, 0.50, 1.14) and Christchurch studies (IRR, 0.69; 95% CI, 0.47, 1.00). Childhood dental caries was not associated with the number of self‐reported physical health conditions in midlife, in either cohort. Dunedin Study members who at age 5 were not caries‐free or whose parents rated their own or their child’s oral health as poor were less likely to report ‘Excellent’ self‐rated general health at age 45 than those who were caries‐free and whose parents did not give a ‘poor’ rating (IRR, 0.69; 95% CI, 0.49, 0.97).ConclusionsFive‐year‐olds with greater caries experience were more likely to have poorer self‐rated general health by midlife. Beyond this longitudinal association, future research should examine whether childhood dental caries is associated with objective/biological markers of physical health and whether it may have utility as an early indicator for poor general health in adulthood.
Influence of apico‐coronal positioning of tissue‐level implants on marginal bone stability during supracrestal tissue height establishment: A multi‐center prospective study
Authors: Spinato Sergio , Bernardello Fabio , Lombardi Teresa , Soardi Carlo Maria , Messina Marcello , Zaffe Davide , Stacchi Claudio 
Published: August 2022

AbstractIntroductionSupracrestal tissue height establishment is a crucial factor influencing peri‐implant marginal bone modifications prior to prosthesis delivery. If mucosal thickness is insufficient, peri‐implant marginal bone resorption occurs to allow appropriate supracrestal tissue height formation. This study evaluates if marginal bone resorption occurring around tissue‐level implants before prosthetic loading could be compensated by adapting apico‐coronal positioning to mucosal thickness.MethodsPatients requiring placement of one single implant in the posterior mandible were treated with tissue‐level implants with a 3‐mm high transmucosal machined component and moderately rough implant body. Based upon vertical mucosal thickness measured after buccal flap reflection, implants were placed with the treated part: (group 1) 2 mm below crestal level in presence of thin mucosa (<2.5 mm); (group 2) 1 mm below the crestal level in presence of medium mucosa (2.5–3.5 mm); (group 3) at equicrestal level in presence of thick mucosa (>3.5 mm).ResultsForty‐nine implants, placed in 49 patients were included in final analysis (group 1: 18 implants; group 2: 16 implants; group 3: 15 implants). Mean marginal bone resorption after 5 months of healing was 0.66 ± 0.49 mm, 0.32 ± 0.41 mm, and 0.22 ± 0.52 mm in groups 1, 2, and 3, respectively. Inter‐group analysis highlighted significant differences between the three groups after ANOVA test (p = 0.025). However, adaptation of apico‐coronal implant positioning in relation to mucosal thickness, allowed to avoid early exposure of the treated surface in 100%, 93.7%, and 53.3% of the implants in groups 1, 2, and 3, respectively.ConclusionDuring supracrestal tissue height formation, tissue‐level implants inserted adapting apico‐coronal positioning in relation to mucosal thickness exhibited greater marginal bone resorption at sites with thin mucosa than at sites with medium or thick mucosa. However, anticipating supracrestal tissue height establishment by adapting apico‐coronal implant positioning in relation to mucosal thickness may effectively prevent unwanted exposure of treated implant surface.
Biodiversity conservation funding in Bhutan: Thematic, temporal, and spatial trends over four decades
Authors: Devkota Dikshya , Miller Daniel C. , Wang Sonam W. , Brooks Jeremy S. 
Published: August 2022

AbstractAccess to sufficient financial resources is vital for effective biodiversity conservation. Although the importance of biodiversity conservation is widely recognized, lack of funding has been a significant impediment to achieving conservation goals. Yet, information on the allocation of conservation funding remains limited. This study addresses this gap by mapping conservation funding flows in Bhutan over the past four decades. We identified 249 projects totaling US$ 239.4 million allocated for biodiversity conservation in Bhutan from 1980 to 2019. Most of this funding derived from bilateral and multilateral aid agencies, with domestic trust fund and private foundations also contributing. Funding for projects with coupled conservation and development objectives and gender components was relatively high, particularly for funds allocated by multilateral and bilateral organizations. By contrast, domestic funding typically did not include development or gender components. Private foundations and domestic sources emphasized capacity development interventions. Despite relatively limited funding flows, the socio‐political context in Bhutan, which favors environmentally friendly practices, may have been key to the country's widely recognized conservation success. Evidence on trends and patterns in conservation finance, as presented here for Bhutan, can advance conservation science and practice by shedding new light on historical and current conservation priorities and helping inform future allocation.