bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association of Simultaneous vs Delayed Resection of Liver Metastasis With Complications and Survival Among Adults With Colorectal Cancer
Authors: Wu Yibin , Mao Anrong , Wang Huipeng , Fang Guojiu , Zhou Jiamin , He Xigan , Cai Sanjun , Wang Lu 
Published: September 2022

ImportanceSimultaneous or delayed resection of synchronous liver metastasis (SLM) with primary colorectal cancer (CRC) remains a controversial topic.ObjectiveTo investigate the outcomes of simultaneous vs delayed resection in patients with resectable SLM.Design, Setting, and ParticipantsThis comparative effectiveness research study included 1569 patients with resectable SLM who underwent curative-intent liver resection at 3 independent centers in China between January 1, 2000, to December 31, 2019. A 1:1 propensity score matching was performed. Follow-up was completed on August 31, 2021, and the data were analyzed from April 1 to 30, 2022.Main Outcomes and MeasuresPrimary outcome was the percentage of patients with at least 1 major complication within 60 days after surgery. Secondary outcomes were intraoperative and postoperative complications, overall survival (OS), and cancer-specific survival (CSS) rates.ResultsAmong the 1569 patients included, 1057 (67.4%) underwent delayed resection (719 men [68.0%] with a mean [SD] age of 57.4 [11.2] years), and 512 patients (310 men [60.5%] with a mean [SD] age of 57.1 [10.5] years) underwent simultaneous resection. Matching yielded 495 pairs of patients underwent simultaneous resection. The percentage of major perioperative complications did not differ between the simultaneous and delayed resection groups (34.1% vs 30.0%; P = .89). The OS rates were 65.2% at 3 years, 47.1% at 5 years, and 38.0% at 8 years for the delayed resection group and 78.0% at 3 years, 65.4% at 5 years, and 63.1% at 8 years for the simultaneous resection group (hazard ratio [HR], 1.42; 95% CI, 1.10-1.85, P = .003). The CSS rates were 68.3% at 3 years, 48.5% at 5 years, and 37.1% at 8 years for the delayed resection group and 79.2% at 3 years, 67.2% at 5 years, and 65.9% at 8 years for the simultaneous resection group (HR, 1.45; 95% CI, 1.14-1.98; P = .004). On subgroup analysis comparing the 2 strategies according to the KRAS sequence variation status, the OS rates (HR, 1.61; 95% CI, 1.45-2.18; P &lt; .001) and CSS rates (HR, 1.62; 95 CI, 1.40-1.87; P = .003]) in the simultaneous resection group were significantly better than those in the delayed resection group in patients with KRAS wild-type tumors.Conclusions and RelevanceResults of this study suggest that complication rates did not differ when CRC and SLM were resected simultaneously and that the survival benefits of simultaneous resection were restricted to patients with KRAS wild-type tumors. Integrating molecular features into the treatment decision is a basis for accurate, individualized treatments.
Performance of Modified ALMS and BLISS Criteria with Standard of Care Treatment in Two US Health Care Systems
Authors: Khosroshahi Arezou , Tong David , Bao Gaobin , Al‐Naqeeb Jinan , Ghosh Pranab , Peeva Elena , Easley Kirk A. , Weiss Roberta , Lim S. Sam 
Published: September 2022

ObjectiveA retrospective cohort study was undertaken in a predominantly Black population undergoing standard treatment for lupus nephritis (LN) to estimate the incidence of, and risk factors for, complete response (CR) according to modified Aspreva Lupus Management Study (mALMS) and modified Belimumab International Study in Lupus Nephritis (mBLISS) criteria by 12 months.MethodsPatients with biopsy‐proven LN class III or IV ± V, urine protein‐to‐creatinine ratio of ≥1gm/gm and estimated glomerular filtration rate of >50 ml/minute/1.73 m2 at the time of the incident LN flare were included. The clinical, treatment, and laboratory factors associated with CR were identified using multivariable Cox regression.ResultsOf 173 patients, 86.1% were women, 77.5% were Black, and over half (59.5%) had non‐commercial insurance. By 12 months, 20.6% (95% confidence interval (95% CI) 14.6–28.6%) achieved mALMS CR and 33.7% (95% CI 26.4–42.4%) achieved mBLISS CR. Factors associated with mBLISS CR were commercial insurance (adjusted CR ratio = 3.5 [95% CI 1.9–6.7]; P < 0.001), albumin (adjusted CR ratio = 1.8 per 1 gm/dl increase in albumin; P = 0.02), and low C4 (adjusted CR ratio = 2.6; P = 0.03). Cumulative incidence of end‐stage renal disease (ESRD) at 3 years was 23.1% (95% CI 15.7–31.3%) and 6.1% (95% CI 2.8–11.1%) for death. Patients with non‐commercial insurance were more likely to develop ESRD, with cumulative incidence of 30.4% (95% CI 19.6–41.9%) compared to 12.7% (95% CI 5.0–24.2%) for patients with commercial insurance (P = 0.024).ConclusionIn a primarily Black, uninsured LN population, despite achieving similar CR rates at 12 months, the incidence of ESRD and death exceeded those observed in controlled clinical trials with placebo arms.
Artificial SEI Film via Synchronous Reaction‐Diffusion‐Assembly on Li Liquid Metal
Authors: Wang Dong , Xie Tian , Qin Chichu , Wang Xianwen , Li Guanwu , Liu Yumin , Zou Haiyan , Huang Lu , Wu Yingpeng 
Published: September 2022

AbstractSolid electrolyte interphase (SEI) is considered as an effective way to suppress Li dendrite. However, most of the constructed SEI films are usually nonuniform and incompact due to the uncertain interface between Li and electrolyte, finally resulting in failure to Li anode protection. To overcome such disadvantage, a stable pristine SEI film is formed successfully by self‐diffusion and assembly when the surface reaction occur between the molten Li and the substrate, benefitting from the ultra‐high chemical activity, atomic level smoothness, and flowability of liquid lithium. It is an inside–outside process via the obtained Li composites migrating from reaction interface to the Li liquid metal surface. Then, the obtained SEI can lead to a stable and long‐lifespan Li integrated electrode, showing the self‐diffusion/assembly strategy upon liquid Li‐metal is a promising way for practical dendrite‐free anode.
Low Thermal Budget Growth of Near‐Isotropic Diamond Grains for Heat Spreading in Semiconductor Devices
Authors: Malakoutian Mohamadali , Zheng Xiang , Woo Kelly , Soman Rohith , Kasperovich Anna , Pomeroy James , Kuball Martin , Chowdhury Srabanti 
Published: September 2022

AbstractThe ever‐increasing power density is a major trend for electronics applications from dense computing to 5G/6G networks. Joule heating and resulting high temperature in the device channel due to the increased power density results in performance degradation and premature failure. Diamond integration near the hot spot can spread the heat by increasing the heat transfer coefficient. Diamond is mostly grown at high temperatures (700–1000 °C), which limits its integration with many semiconductor technologies. Here, a high‐quality 400 °C‐diamond by modifying the gas chemistry at different nucleation stages, with a sharp sp3 Raman peak (FWHM≈6.5 cm−1) and high phase purity (97.1%), similar to 700 °C‐diamond (>98%) is demonstrated. An average grain size of 650 nm with a thickness of 790 nm corresponding to an anisotropy ratio of 1.21 at 400 °C close to the best‐reported of 1.12 at 700 °C is achieved. This near‐isotropic diamond exhibits a relatively high thermal conductivity of ≈300 W m−1 K−1 and a thermal boundary resistance as small as only 5 m2K G−1 W−1 (on SiO2 and Si3N4). Achieving such a high‐quality diamond at 400 °C demonstrates the possibility to grow the diamond on a wide range of semiconductors including Si, InP, Ga2O3, SiC, and GaN where SiO2 or its variations, and Si3N4 are commonly used dielectrics.
Self‐driven Electrical Stimulation Promotes Cancer Catalytic Therapy Based on Fully Conjugated Covalent Organic Framework Nanocages
Authors: Yao Shuncheng , Zheng Minjia , Wang Shaobo , Huang Tian , Wang Zhuo , Zhao Yunchao , Yuan Wei , Li Zhou , Wang Zhong Lin , Li Linlin 
Published: September 2022

AbstractEngineered nanozymes have been developed to catalyze the production of reactive oxygen species (ROS) for cancer therapy, but currently, the ROS generation efficiency is still far from optimistic. In this study, a human self‐driven electrical stimulation enhanced catalytic system based on wearable triboelectric nanogenerator (TENG) and fully π‐conjugated covalent organic framework nanocages (hCOF) for improving cancer therapy is created. The fully π‐conjugated hCOF nanocage with high electron mobility under the self‐generated electric field can not only rearrange the local electric field for optimizing energy utilization, but also facilitates the access of electrolytes to optimize the utilization of the electric field. With the self‐powered wearable TENG, the peroxidase‐like activity of hCOF increased by 2.44‐fold and has electricity‐responsive doxorubicin delivery capacity for enhancing the therapeutic outcomes. The high‐efficient self‐driven electrical stimulation enhanced nanocatalytic system provides a new optimized model for the catalytic energy supply of nanozymes.
Polaritons in Van der Waals Heterostructures
Authors: Guo Xiangdong , Lyu Wei , Chen Tinghan , Luo Yang , Wu Chenchen , Yang Bei , Sun Zhipei , García de Abajo F. Javier , Yang Xiaoxia , Dai Qing 
Published: September 2022

Abstract2D monolayers supporting a wide variety of highly confined plasmons, phonon polaritons, and exciton polaritons can be vertically stacked in van der Waals heterostructures (vdWHs) with controlled constituent layers, stacking sequence, and even twist angles. vdWHs combine advantages of 2D material polaritons, rich optical structure design, and atomic scale integration, which have greatly extended the performance and functions of polaritons, such as wide frequency range, long lifetime, ultrafast all‐optical modulation, and photonic crystals for nanoscale light. Here, the state of the art of 2D material polaritons in vdWHs from the perspective of design principles and potential applications is reviewed. Some fundamental properties of polaritons in vdWHs are initially discussed, followed by recent discoveries of plasmons, phonon polaritons, exciton polaritons, and their hybrid modes in vdWHs. The review concludes with a perspective discussion on potential applications of these polaritons such as nanophotonic integrated circuits, which will benefit from the intersection between nanophotonics and materials science.
An Electric‐Field‐Reinforced Hydrophobic Cationic Sieve Lowers the Concentration Threshold of Water‐In‐Salt Electrolytes
Authors: Zhou Anxing , Zhang Jinkai , Chen Ming , Yue Jinming , Lv Tianshi , Liu Binghang , Zhu Xiangzhen , Qin Kun , Feng Guang , Suo Liumin 
Published: September 2022

AbstractHigh‐concentration water‐in‐salt (WIS) electrolytes expand the stable electrochemical window of aqueous electrolytes, leading to the advent of high‐voltage (above 2 V) aqueous Li‐ion batteries (ALIBs). However, the high lithium salt concentration electrolytes of ALIBs result in their high cost and deteriorate kinetic performance. Therefore, it is challenging for ALIBs to explore aqueous electrolytes with appropriate concentration to balance the electrochemical window and kinetic performance as well as the cost. In contrast to maintaining high concentrations of aqueous electrolytes (>20 m), a small number of hydrophobic cations are introduced to a much lower electrolyte concentration (13.8 m), and it is found that, compared with WIS electrolytes, ALIBs with these concentration‐lowered electrolytes possess a compatible stable electrochemical window (3.23 V) and achieve better kinetic performance. These findings originate from the added cations, which form an electric‐field‐reinforced hydrophobic cationic sieve (HCS) that blocks water away from the anode and suppresses the hydrogen evolution reaction. Meanwhile, the lower electrolyte concentration provides significant benefits to ALIBs, including lower cost, better rate capability (lower viscosity of 18 cP and higher ionic conductivity of 22 mS cm−1 at 25 °C), and improved low‐temperature performance (liquidus temperature of −10.18 °C).
ortho‐Acylation of Aryl Iodides Enabled with Imides via Palladium/Norbornene/CuI Catalysis
Authors: Zhao Shen , Yang Shimin , Du Guopeng , Zhang Daopeng , Liu Hui , Sun Feng‐Gang 
Published: September 2022

AbstractHerein, a three component Catellani‐type reaction catalyzed by the Palladium/Norbornene/CuI (Pd/NBE/CuI) cooperative system by using N‐acylph‐thalimides as acyl electrophiles is reported, which gives access to a series of aromatic ketones. The transformation is performable in the presence of water, albeit with decreased reaction yield. The additive CuI was crucial to facilitate the cleavage of C(O)−N bond of imide. This protocol showed broad substrate scope: both alkyl and aryl acyl groups could be installed at the ortho‐position of aryl iodides; alkenes and boronic acids can be used as termination reagents.magnified image
Ti3C2TxMXene Composite 3D Hydrogel Potentiates mTOR Signaling to Promote the Generation of Functional Hair Cells in Cochlea Organoids
Authors: Zhang Zhong , Gao Shan , Hu Yang‐Nan , Chen Xin , Cheng Cheng , Fu Xiao‐Long , Zhang Sha‐Sha , Wang Xin‐Lin , Che Yu‐Wei , Zhang Chen , Chai Ren‐Jie 
Published: September 2022

AbstractOrganoids have certain cellular composition and physiological features in common with real organs, making them promising models of organ formation, function, and diseases. However, Matrigel, the commonly used animal‐derived matrices in which they are developed, has limitations in mechanical adjustability and providing complex physicochemical signals. Here, the incorporation of Ti3C2TxMXene nanomaterial into Matrigel regulates the properties of Matrigel and exhibits satisfactory biocompatibility. The Ti3C2TxMXene Matrigel composites (MXene‐Matrigel) regulate the development of Cochlear Organoids (Cochlea‐Orgs), particularly in promoting the formation and maturation of organoid hair cells. Additionally, regenerated hair cells in MXene‐Matrigel are functional and exhibit better electrophysiological properties compared to hair cells in Matrigel. MXene‐Matrigel potentiates the amycin (mTOR) signaling pathway to promote hair cell differentiation, and mTOR signaling inhibition restrains hair cell differentiation. Moreover, MXene‐Matrigel facilitates innervation establishment between regenerated hair cells and spiral ganglion neurons (SGNs) growing from the Cochlea modiolus in a co‐culture system, as well as promotes synapse formation efficiency. The approach overcomes some limitations of the Matrigel‐dependent culture system and greatly accelerates the application of nanomaterials in organoid development and research on therapies for hearing loss.
Full Control of the Chiral Overpass Effect in Helical Polymers: P/M Screw Sense Induction by Remote Chiral Centers After Bypassing the First Chiral Residue
Authors: Rodríguez Rafael , Rivadulla‐Cendal Elena , Fernández‐Míguez Manuel , Fernández Berta , Maeda Katsuhiro , Quiñoá Emilio , Freire Félix 
Published: September 2022

AbstractIn helical polymers, helical sense induction is usually commanded by teleinduction mechanism, where the largest substituent of the chiral residue directly attached to the main chain is the one that commands the helical sense. In this work, different helical structures with different helical senses are induced in a helical polymer [poly‐(phenylacetylene)] when the conformational composition of two different dihedral angles of a pendant group with more than two chiral residues is tamed. Thus, while the dihedral angle at chiral residue1[(R)‐ or (S)‐alanine], attached to the backbone, produces an extended or bent conformation in the pendant resulting in two scaffolds with different stretching degree, the second dihedral angle at chiral residue2[(R)‐ or (S)‐methoxyphenylacetamide] places the substituents of this chiral center in a different spatial orientation, originating opposite helical senses at the polymer that are induced through a total control of the “chiral overpass effect”.
Large‐Scale Self‐Assembly of MOFs Colloidosomes for Bubble‐Propelled Micromotors and Stirring‐Free Environmental Remediation
Authors: Huang Hai , Li Jie , Yuan Mengge , Yang Haowei , Zhao Yu , Ying Yulong , Wang Sheng 
Published: September 2022

AbstractThe design of MOF‐based micromotors (MOFtors) is still challenging and with limited approaches, especially for the MOF nanoparticles (NPs). Herein, we report a universal and straightforward strategy to efficiently self‐assembly MOF NPs into robust MOFtors for enhanced organic‐ or heavy‐metal‐ion‐contaminants remediation without mechanical stirring. Based on the transient Pickering emulsion method, Fe3O4@NH2‐UiO‐66 (Fe‐UiO) NPs are rapidly self‐assembled into Fe3O4@NH2‐UiO‐66 colloidosomes (Fe‐UiOSomes) on a large scale, and the formation mechanism is systematically studied. The Fe‐UiOSomes‐Pt micromotors through chemical reduction (Micromotor‐C) presented a higher motility of 450±180 μm s−1 in a 5 wt% H2O2 aqueous solution. Finally, the bubble‐propelled Micromotor‐C was employed to efficiently remove dyes and heavy metal ions (94 % for MO and 91 % for CrVI).
Structure of the (Bi)carbonate Adlayer on Cu(100) Electrodes
Authors: Amirbeigiarab Reihaneh , Bagger Alexander , Tian Jing , Rossmeisl Jan , Magnussen Olaf M. 
Published: September 2022

Abstract(Bi)carbonate adsorption on Cu(100) in 0.1 M KHCO3 has been studied by in situ scanning tunneling microscopy. Coexistence of different ordered adlayer phases with (
×6
)R45° and (4×4) unit cells was observed in the double layer potential regime. The adlayer is rather dynamic and undergoes a reversible order‐disorder phase transition at 0 V vs. the reversible hydrogen electrode. Density functional calculations indicate that the adlayer consists of coadsorbed carbonate and water molecules and is strongly stabilized by liquid water in the adjacent electrolyte.
Integrating a Far‐Red Fluorescent Probe with a Microfluidic Platform for Super‐Resolution Imaging of Live Erythrocyte Membrane Dynamics**
Authors: Ye Zhiwei , Yang Wei , Zheng Ying , Wang Shujing , Zhang Xiaodong , Yu Haibo , Li Shuangshuang , Luo Chunxiong , Peng Xiaojun , Xiao Yi 
Published: September 2022

AbstractLiving erythrocyte (red blood cell, RBC) membranes present rich ultrastructural and dynamic details, which require synchronous super‐resolution imaging and single‐molecule tracking to be revealed. Yet, it poses a serious challenge to achieve these dual functions in a single probe, due to the rigid and conflicting photophysical demands of the different techniques. Herein, we rationally developed a far‐red boron dipyrromethene membrane probe with blinking capability and persistent single‐molecule emission, and constructed a microfluidic platform for noninvasive trapping and long‐term imaging of RBCs. By combining them, multi‐dimensional super‐resolution reconstructions and single‐molecule tracking were achieved at the molecular scale on living human RBC membranes in a high‐throughput manner. Our integrated system defines a quantitative method for analyzing RBC membranes under physiological and pathological conditions, improving precision and revealing new perspectives for future disease diagnostics.
Semisynthetic Viral Inhibitor for Light Control of the MHC I Peptide Loading Complex
Authors: Winter Christian , Domnick Alexander , Cernova Darja , Tampé Robert 
Published: September 2022

AbstractThe immune system detects virally or malignantly transformed cells via peptide‐loaded major histocompatibility complex class I (pMHC I) molecules on the cell surface. MHC I molecules are loaded with cargo peptides in the endoplasmic reticulum (ER) by the highly dynamic multiprotein peptide loading complex (PLC). Here, we developed a semisynthetic approach to generate a photocleavable immune modulator ICP47 of Herpes simplex virus. Using this nanotool, we revealed key mechanistic events of the purified PLC, such as peptide binding and translocation coupled to ATP hydrolysis, triggered by light. We established a single‐organelle flow cytometry assay to monitor light‐controlled activation of the antigen processing machinery in native ER membranes. This photochemical modulation opens new opportunities for a comprehensive mechanistic analysis of the antigen processing machinery in vitro and native membrane environment.
Quantifizierung der Reduktiven Aminierung in Nichtenzymatischer Aminosäuresynthese
Authors: Mayer Robert J. , Moran Joseph 
Published: September 2022

AbstractDie Biosynthese von Aminosäuren beginnt mit der reduktiven Aminierung von α‐Ketoglutarat mit Ammoniak, wobei Glutamat entsteht. Die anderen α‐Ketosäuren, die aus dem Glyoxylat‐ oder Krebszyklus stammen, werden jedoch eher durch Transaminierung als durch reduktive Aminierung in Aminosäuren umgewandelt. Warum wird nur eine Aminosäure durch reduktive Aminierung synthetisiert und die anderen nicht? Um diese Frage zu untersuchen, haben wir die intrinsischen Reaktivitäten von Ketosäuren in nichtenzymatischen Reduktionen und reduktiven Aminierungen unter Verwendung von BH3CN− als Modellnucleophil quantifiziert. Dabei wurde festgestellt, dass biologische α‐Ketosäuren ausgeprägte nichtenzymatische Reaktivitätsunterschiede für die Bildung von Aminosäuren aufweisen (α‐Ketoglutarat<Oxalacetat≈Pyruvat≪Glyoxylat). Entsprechend durchläuft der Einbau von Ammoniak die am wenigsten reaktive α‐Ketosäure des Krebszyklus. Eine mögliche Erklärung für diese Wahl ist die Position der entsprechenden Aminosäure Glutamat an der Spitze der thermodynamischen Landschaft für nachfolgende Transaminierungsreaktionen.
Strain Control to Stabilize Perovskite Solar Cells
Authors: Zhang Hui , Park Nam‐Gyu 
Published: September 2022

AbstractPerovskite solar cells (PSCs) are rivaling most commercial photovoltaics in the aspect of efficiency and cost, while their intrinsic instability remains a major concern for their practical deployment. The presence of undesirable strain in PSCs during device fabrication and operation refers to the extension/narrowing of chemical bonds and expansion/shrinkage of lattice volume, which largely affects device stability due to promoted phase transition, chemical decomposition, and mechanical fragility. Pioneering investigations and remarkable achievements have revealed that strain control is indispensable in the design of stable PSCs. Herein, the evolution of strain in perovskite thin films and its effect on device performance is elucidated, and state‐of‐the‐art strategies of strain modulation are systematically reviewed. A thorough understanding and cautious control of the strain‐related phenomenon pave the pathway to derive perovskite materials with desired properties.
RealizingzT>2 in Environment‐Friendly Monoclinic Cu2S—Tetragonal Cu1.96S Nano‐Phase Junctions for Thermoelectrics
Authors: Li Xiaokun , Lou Yue , Jin Kangpeng , Fu Liangwei , Xu Pengfei , Shi Zhan , Feng Tianli , Xu Biao 
Published: September 2022

AbstractPhase‐junction nanocomposites, made of nanograins with the same composition but different phases, offer a platform to optimize the physiochemical performance of materials. Herein, we demonstrate a straightforward strategy to synthesize Cu2−xS phase‐junction nanocomposites by retaining surface 1‐dodecanethiol (DDT) ligands, in contrast to the traditional method that strips the ligands. As a result, phase junctions between a conventional monoclinic (m) phase and an unconventional metastable tetragonal (t) phase are obtained. The significantly improved power factor is obtained due to the doping of the t‐phase. The phase‐junction interfaces reduce thermal conductivity. Finally, surface regulation of phase junctions pushes the peakzTto 2.1 at 932 K, being the highest reported for environment‐friendly metal sulfides. This work provides a paradigm to optimize thermoelectric performance by controlling phase junctions through surface‐ligand tuning.