bluuebunny/crossref_metadata_2025_split huggingface dataset:
Repeated measurements of non‐invasive fibrosis tests to monitor the progression of non‐alcoholic fatty liver disease: A long‐term follow‐up study
Authors: Balkhed Wile , Åberg Fredrik O. , Nasr Patrik , Ekstedt Mattias , Kechagias Stergios 
Published: March 2022

AbstractBackground and AimsThe presence of advanced hepatic fibrosis is the prime marker for the prediction of liver‐related complications in non‐alcoholic fatty liver disease (NAFLD). Blood‐based non‐invasive tests (NITs) have been developed to evaluate fibrosis and identify patients at risk. Current guidelines propose monitoring the progression of NAFLD using repeated NITs at 2–3‐year intervals. The aim of this study was to evaluate the association of changes in NITs measured at two time points with the progression of NAFLD.MethodsWe retrospectively included NAFLD patients with NIT measurements in whom the baseline hepatic fibrosis stage had been assessed by biopsy or transient elastography (TE). Subjects underwent follow‐up visits at least 1 year from baseline to evaluate the progression of NAFLD. NAFLD progression was defined as the development of end‐stage liver disease or fibrosis progression according to repeat biopsy or TE. The following NITs were calculated at baseline and follow‐up: Fibrosis‐4 (FIB‐4), NAFLD fibrosis score (NFS), aspartate aminotransferase to platelet ratio index (APRI) and dynamic aspartate‐to‐alanine aminotransferase ratio (dAAR).ResultsOne hundred and thirty‐five patients were included with a mean follow‐up of 12.6 ± 8.5 years. During follow‐up, 41 patients (30%) were diagnosed with progressive NAFLD. Change in NIT scores during follow‐up was significantly associated with disease progression for all NITs tested except for NFS. However, the diagnostic precision was suboptimal with area under the receiver operating characteristics 0.56–0.64 and positive predictive values of 0.28–0.36 at sensitivity fixed at 90%.ConclusionsChange of FIB‐4, NFS, APRI, and dAAR scores is only weakly associated with disease progression in NAFLD. Our findings do not support repeated measurements of these NITs for monitoring the course of NAFLD.
Feeding practices of children within institution‐based care: A retrospective analysis of surveillance data
Authors: DeLacey Emily , Allen Elizabeth , Tann Cally , Groce Nora , Hilberg Evan , Quiring Michael , Kaplan Tracy , Smythe Tracey , Kaui Erin , Catt Rachael , Miller Raeanne , Gombo Maijargal , Dam Hang , Kerac Marko 
Published: March 2022

AbstractThere is limited information on the feeding practices of 9.42 million children living within institution‐based care (IBC) worldwide. Poor feeding practices can predispose or exacerbate malnutrition, illness and disability. Here we describe the feeding practices of children living within IBC based on a retrospective analysis of records from 3335 children, 0–18 years old, participating in Holt International's Child Nutrition Program (CNP), from 36 sites in six countries. Data analysed included demographic information on age, sex, feeding practices, disabilities and feeding difficulties. Descriptive statistics were produced. A generalised linear model explored associations between feeding difficulties and disability and 2 × 2 tables examined feeding difficulties over time. An additional set of feeding observations with qualitative and quantitative data was analysed. At baseline, the median age of children was 16 months (0.66–68 months) with 1650/3335 (49.5%) females. There were 757/3335 (22.7%) children with disabilities; 550/984 (55.9%) were low birth weight; 311/784 (39.7%) were premature; 447/3113 (14.4%) had low body mass index and 378/3335 (11.3%) had feeding difficulties. The adjusted risk of having a feeding difficulty was 5.08 ([95% confidence interval: 2.65–9.7], p ≤ 0.001) times greater in children with disabilities than those without. Many children saw their feeding difficulties resolve after 1‐year in CNP, 54/163 (33.1%) for children with disabilities and 57/106 (53.8%) for those without disabilities. Suboptimal hygiene, dietary and feeding practices were reported. In conclusion, feeding difficulties were common in IBC, especially among children with disabilities. Supporting safe interactive mealtimes for children living within IBC should be prioritised, to ensure overall health and development.
Now you're tax‐exempt, now you're not: Property taxation of assisted living facilities
Authors: Larson Sarah E. , Carroll Deborah A. 
Published: March 2022

AbstractThis research is motivated by a change in Florida that affected assisted living facilities (ALFs) by removing the property tax exemptions for those operated by nonprofit organizations. As such, this paper addresses two research questions: (1) Are there systematic differences between Florida's for‐profit‐ and nonprofit‐designated ALFs in terms of operations and service provision? (2) What was the impact, if any, of losing and regaining their property tax exemptions on the operations of Florida's nonprofit ALFs? We use data from the Florida Agency for Health Care Administration to conduct difference of means testing for‐profit versus nonprofit ALFs, as well as annual financial data of each ALF property owners' IRS Form 990 from the National Center for Charitable Statistics Core Files and parcel‐level property data from the state of Florida to conduct regression analysis using three different dependent variables measuring various components of nonprofit ALF operations. We find that nonprofit ALFs have greater legitimacy in service delivery than for‐profits, as nonprofit ALFs have higher service capacity, quality, and variety than for‐profit ALFs in Florida. In addition, property tax exemptions for nonprofit ALFs in Florida decrease total expenses and increase officer compensation.
Genomic dissection reveals QTLs for grain biomass and correlated traits under drought stress in Ethiopian durum wheat (Triticum turgidum ssp.durum)
Authors: Negisho Kefyalew , Shibru Surafel , Matros Andrea , Pillen Klaus , Ordon Frank , Wehner Gwendolin 
Published: March 2022

AbstractDrought stress seriously challenges wheat production and productivity. Grain biomass (GB) and related traits were assessed under drought stress and non‐stress for 285 and 185 durum wheat genotypes, respectively, in field and climate chamber experiments to identify quantitative trait loci (QTL). Significant correlations between traits estimated in field and climate chamber trials were observed (p < .001). Genotyping with the wheat 90 K iSelect single nucleotide polymorphism (SNP) array revealed 11,919 polymorphic SNP markers distributed across the durum wheat genome. The FarmCPU (Fixed and random model Circulating Probability Unification) method was used for genome‐wide association studies (GWAS). A total of 191 significant (−log10p ≥ 4) marker‐trait associations (MTAs) were detected at a linkage disequilibrium (LD,r2 ≥ .2) at 4.78 Mb and were clustered into 70 QTLs. A total of 69 (36%) of the MTAs passed a false discovery rate (FDR) of 5%. The numbers of QTLs detected were 21, 31, 9 and 9 under field drought stress (FDS), field non‐stress (FNS), climate chamber drought stress (CCDS) and climate chamber non‐stress (CCNS) conditions, respectively. About 43% and 57% of the QTLs were located on the A and B genomes, respectively. Some of the detected QTLs were in agreement with previously reported QTLs, while others are novel ones for the traits investigated. QTLs on 1A between 495694477and ‐501944537bp, on 3B between 416256124 and 430507900 bp, on 3B between 745357158 and 759608934 bp, on 4B between 593416763 and 605142497 bp and on 4B between 658785890 and 670511624 bp were selected for validation and may be used to increase grain yield under drought stress in marker‐assisted selection (MAS) schemes.Key messageGenome‐wide association studies (GWAS) enabled detecting novel quantitative trait loci (QTLs) and identifying single nucleotide polymorphism (SNP) markers associated with grain biomass and correlated traits for drought stress tolerance in durum wheat based on a combination of climate chamber and multiyear and multilocation field experiments.
Antinuclear antibody pattern and autoantibody profiling of systemic sclerosis patients in a tertiary referral center in North India
Authors: Machhua Sanghamitra , Sharma Shefali K. , Kumar Yashwant , Anand Shashi , Handa Sanjeev , Minz Ranjana W. 
Published: March 2022

AbstractAntinuclear antibody (ANA) pattern and autoantibody (autoAb) profiling of 150 adult systemic sclerosis (SSc) patients concerning their clinical association and diagnostic significance were analyzed by indirect immunofluorescence (IIF), immunoblot, and fluorescence enzyme immunoassay. One hundred and forty‐three (95.3%) patients had positive ANA: DNA topoisomerase I (topo I)‐like pattern‐84(56%); speckled pattern‐44(29.3%);centromere pattern‐7(4.6%); and nucleolar pattern‐4(2.6%). Three distinct topo I‐like immunofluorescence patterns were detected at 1:40 dilution. Topo I‐like pattern (32/75–limited cutaneous systemic sclerosis (lcSSc) vs. 52/75‐diffuse cutaneous systemic sclerosis (dcSSc); p < 0.001) was found to be associated with dcSSc subset and speckled pattern (lcSSc 28/75 vs. dcSSc 16/75; p < 0.03) with lcSSc subset. One hundred and thirty‐eight (92%) patients were positive for SSc‐associated autoAbs. The frequency distribution of autoAbs to topo I, centromere A (CENP A) and centromereB (CENP B), RNA polymerase III (RP11, RP155), fibrillarin (U3RNP), nucleolus organizer region (NOR)‐90, Th/To, PM‐Scl75, PM‐Scl100, Ku, platelet‐derived growth factor receptor (PDGFR) and Ro‐52, were 87(58%), 9(6%), 8(5.3%), 6(4%), 9(6%), 0, 6(4%), 6(4%), 8(5.3%), 5(3.3%), 11(7.3%),0 and 46(30.6%), respectively. Topo I autoAb was strongly associated with dcSSc (35/75 lcSSc vs. 52/75 dcSSc; p < 0.004), Raynaud's (p < 0.003), interstitial lung disease (ILD) (p < 0.001) and pulmonary arterial hypertension (PAH) (p < 0.04). This study helps in defining SSc clinical subset, prognostic markers of disease severity, characterization of the topo I‐like ANA pattern, and provides a definite association between the ANA patterns and corresponding autoAb.
Publication guidelines and recommendations for pupillary measurement in psychophysiological studies
Authors: Steinhauer Stuart R. , Bradley Margaret M. , Siegle Greg J. , Roecklein Kathryn A. , Dix Annika 
Published: March 2022

AbstractA variety of psychological and physical phenomena elicit variations in the diameter of pupil of the eye. Changes in pupil size are mediated by the relative activation of the sphincter pupillae muscle (decrease pupil diameter) and the dilator pupillae muscle (increase pupil diameter), innervated by the parasympathetic and sympathetic branches, respectively, of the autonomic nervous system. The current guidelines are intended to inform and guide psychophysiological research involving pupil measurement by (1) summarizing important aspects concerning the physiology of the pupil, (2) providing methodological and data‐analytic guidelines and recommendations, and (3) briefly reviewing psychological phenomena that modulate pupillary reactivity. Because of the increased ease and tractability of pupil measurement, the goal of these guidelines is to promote accurate recording, analysis, and reporting of pupillary data in psychophysiological research.
Recent advances and future directions in practical diet formulation and adoption in tropical Palinurid lobster aquaculture
Authors: Nankervis Leo , Jones Clive 
Published: March 2022

AbstractThe spiny lobsters Panulirus ornatus and Panulirus homarus are important developing tropical aquaculture species, with high demand and limited supply. The established industry in Vietnam relies on wild‐caught mixed seafood bycatch as feed, a practice linked to water quality degradation and potentially disease proliferation in lobster aquaculture, necessitating formulated feed development. The emerging Indonesian and Australian industries lack the crustacean and mollusc component of the seafood bycatch used in Vietnam, increasing the need for manufactured feeds. The development of such feeds is reliant on knowledge of nutrient requirements, ingredient quality, physical feed requirements, and the link between feeding behaviour and feeding methods. This review will elaborate on the development of these knowledge areas to date and outline the two main reference diet recipes that are available as the basis for future research. Research to date has focused on developing a feed recipe that will be consumed and supports adequate growth rather than steering commercial least‐cost formulation practices. Future research is clearly needed to inform formulation, but equally an understanding of the disparate emerging lobster farming industries and their drivers for the adoption of formulated feeds is required to ensure that such research is applied. This will require engagement throughout the supply chain to ensure that research is implementable and to address farmer perception toward formulated feeds. Technical aspects of feed manufacture and scale‐up of feed developments will be critical to the adoption of research results, while validation through semi‐commercial benchmarks and demonstration farm models are expected to increase commercial uptake of developed feeds.
A family of models in support of realistic drug interdiction location decision‐making
Authors: Price Ashleigh N. , Curtin Kevin M. , Magliocca Nicholas R. , Turner Daniel , Mitchell Penelope , McSweeney Kendra , Summers Diana L. 
Published: March 2022

AbstractLong‐standing federal drug‐control policy aims to reduce the flow of narcotics into the USA, in part by intercepting cocaine shipments en route from South American production regions to North American consumer markets. Drug interdiction efforts operate over a large geographic area, containing complex drug trafficking networks in a dynamic environment. The extant interdiction models in the operations research and location science literature do not realistically model the objectives of and constraints on the interdiction forces, and therefore counterdrug organizations do not employ those models in their decision‐making processes. This article presents three new models built on the maximal covering location problem (MCLP): the maximal covering location problem for interdiction (MCLP‐I), multiple‐demand maximal covering location problem (MD‐MCLP), and multiple‐type maximal covering location problem (MT‐MCLP). These are novel formulations that permit multiple types of demands and facilities to be covered, and the utility of these formulations is demonstrated in the context of counterdrug operations. Optimal interdiction locations are determined within the geography of the Central American transit zone, using a coupled GIS and optimization framework. The results identify the optimal interdiction locations for known or estimated drug shipments and can constrain those optimal locations by differentiating among drug traffickers, the types of interdiction resources, and agency jurisdictions. This research both demonstrates the flexibility in designing alternative interdiction scenarios and presents novel covering models that may be extended to other application areas and operational contexts.
Visions of TAVR Future: Development and Optimization of a Second Generation Novel Polymeric TAVR
Authors: Kovarovic Brandon , Helbock Ryan , Baylous Kyle , Rotman Oren M. , Slepian Marvin J. , Bluestein Danny 
Published: March 2022

AbstractTissue-based transcatheter aortic valve (AV) replacement (TAVR) devices have been a breakthrough approach for treating aortic valve stenosis. However, with the expansion of TAVR to younger and lower risk patients, issues of long-term durability and thrombosis persist. Recent advances in polymeric valve technology facilitate designing more durable valves with minimal in vivo adverse reactions. We introduce our second-generation polymeric transcatheter aortic valve (TAV) device, designed and optimized to address these issues. We present the optimization process of the device, wherein each aspect of device deployment and functionality was optimized for performance, including unique considerations of polymeric technologies for reducing the volume of the polymer material for lower crimped delivery profiles. The stent frame was optimized to generate larger radial forces with lower material volumes, securing robust deployment and anchoring. The leaflet shape, combined with varying leaflets thickness, was optimized for reducing the flexural cyclic stresses and the valve's hydrodynamics. Our first-generation polymeric device already demonstrated that its hydrodynamic performance meets and exceeds tissue devices for both ISO standard and patient-specific in vitro scenarios. The valve already reached 900 × 106 cycles of accelerated durability testing, equivalent to over 20 years in a patient. The optimization framework and technology led to the second generation of polymeric TAV design- currently undergoing in vitro hydrodynamic testing and following in vivo animal trials. As TAVR use is rapidly expanding, our rigorous bio-engineering optimization methodology and advanced polymer technology serve to establish polymeric TAV technology as a viable alternative to the challenges facing existing tissue-based TAV technology.
Insight to Innovation- an Overview of Research Journey of Dr. Satish Kandlikar
Authors: Raghupathi Pruthvik , Owens Alyssa , Steinke Mark , Lin Ting Yu , Kalani Ankit , Moreira Debora , Gonzalez-Hernandez Jose-Luis , Lu Zujie , Banerjee Rupak , Daino Michael , Jaikumar Arvind , Chauhan Aranya , Rishi Aniket , Raya Isaac Parez , Emery Travis , Guimarães Aguiar Fernando 
Published: March 2022

Abstract
Professor Satish G. Kandlikar has been an outstanding researcher in the field of heat transfer having published some of the most widely cited publications over the last 30 years. Throughout these years, he has co-authored 212 journal paper in various areas of heat transfer. The present paper provides a compressive look at Professor Kandlikar's research work over the years. The research work has been broadly categorized into 1) flow boiling correlations, 2) fluid flow and heat transfer in microchannels, 3) roughness effect at microscale, 4) pool boiling heat transfer and CHF modeling, 5) surface enhancements for pool boiling, 6) numerical modeling of bubble growth in boiling, 7) water transport in PEM fuel cells and 8) infrared imaging to detect breast cancer. The research conducted in each of these areas has produced some landmark findings, some of the most widely used theoretical models and an abundance of high quality experimental data. The focus of this paper is to collate major finding and highlights some of the common themes that guided the research in Professor Kandlikar's group. This will help the readers gain a broad understanding of each of the areas of study in Professor Kandlikar's group and place the findings of the papers in a larger context.
Global eHealth capacity: secondary analysis of WHO data on eHealth and implications for kidney care delivery in low-resource settings
Authors: Okpechi Ikechi G , Muneer Shezel , Ye Feng , Zaidi Deenaz , Ghimire Anukul , Tinwala Mohammed M , Saad Syed , Osman Mohamed A , Lunyera Joseph , Tonelli Marcello , Caskey Fergus , George Cindy , Kengne Andre P , Malik Charu , Damster Sandrine , Levin Adeera , Johnson David , Jha Vivekanand , Bello Aminu K 
Published: March 2022

ObjectiveTo describe the use of electronic health (eHealth) in support of health coverage for kidney care across International Society of Nephrology (ISN) regions.DesignSecondary analysis of WHO survey on eHealth as well as use of data from the World Bank, and Internet World Stats on global eHealth services.SettingA web-based survey on the use of eHealth in support of universal health coverage.Participants125 WHO member states provided response.Primary outcome measuresAvailability of eHealth services (eg, electronic health records, telehealth, etc) and governance frameworks (policies) for kidney care across ISN regions.ResultsThe survey conducted by the WHO received responses from 125 (64.4%) member states, representing 4.4 billion people globally. The number of mobile cellular subscriptions was <100% of the population in Africa, South Asia, North America and North East Asia; the percentage of internet users increased from 2015 to 2020 in all regions. Western Europe had the highest percentage of internet users in all the periods: 2015 (82.0%), 2019 (90.7%) and 2020 (93.9%); Africa had the least: 9.8%, 21.8% and 31.4%, respectively. The North East Asia region had the highest availability of national electronic health record system (75%) and electronic learning access in medical schools (100%), with the lowest in Africa (27% and 39%, respectively). Policies concerning governance aspects of eHealth (eg, privacy, liability, data sharing) were more widely available in high-income countries (55%–93%) than in low-income countries (0%–47%), while access to mobile health for treatment adherence was more available in low-income countries (21%) than in high-income countries (7%).ConclusionThe penetration of eHealth services across ISN regions is suboptimal, particularly in low-income countries. Increasing utilisation of internet communication technologies provides an opportunity to improve access to kidney education and care globally, especially in low-income countries.
Transforaminal lumbar puncture for spinal anesthesia or novel drug administration: a technique combining C-arm fluoroscopy and ultrasound
Authors: Berde Charles , Formanek Anna , Khan Asif , Camelo Carlos Rafael , Koka Anjali , Riley Bobbie L , Padua Horacio 
Published: March 2022

BackgroundLumbar puncture (LP) may be challenging for patients with scoliosis and other conditions following previous posterior fusion and instrumentation from thoracic to sacral levels. Interventional radiologists have described CT approaches to transforaminal LP. We hypothesized that combined C-arm fluoroscopy and ultrasound could be a feasible approach to transforaminal LP for interventional pain physicians and regional anesthesiologists.MethodsWith institutional review board approval, we reviewed medical records and imaging of six patients with spinal muscular atrophy and prior spine fusion. Non-cutting needles of 24 or 25 gage were advanced through 20-gage introducers. Prior imaging guided selection of a preferred side and spinal level. Initial procedures were performed in the interventional radiology suite. Subsequent procedures were performed in an operating room (OR). We report on technical success and complications and describe a case using this approach for spinal anesthesia.ResultsSix patients underwent a total of 54 transforaminal LPs, including 51 for administration of the antisense oligonucleotide nusinersen, 2 for myelography, and 1 for spinal anesthesia; 45 of these procedures were performed using OR C-arm fluoroscopy and ultrasound. Transient paresthesias and short-term headaches occurred; none required intervention. No other complications were noted.ConclusionsTransforaminal LP appears technically feasible for patients with full-spine fusions using a straight-needle approach with combined fluoroscopy and ultrasound guidance. Larger case series and prospective studies may better define the success rates, risks, and benefits of this approach relative to alternative approaches to intrathecal access for patients with previous long-segment posterior spine fusions.