bluuebunny/crossref_metadata_2025_split huggingface dataset:
Legitimacy and effectiveness concerns in China’s private antitrust enforcement regime: a comparative analysis with the EU and US regimes
Authors: Wang Jing , Cahill Dermot 
Published: December 2022

Abstract
The year 2007 heralded a major advance in China’s entry to the global economy’s rules-based marketplace. Its Anti-MonopolyLaw 2007 (AML 2007) taking inspiration from European Union (EU) antitrust concepts contained internationally familiar key antitrust prohibitions. It appeared to satisfy key benchmarks, which any credible antitrust enforcement system should exhibit, namely Legitimacy and Effectiveness. However, in this original contribution, analysing 14 years of leading case law, the authors identify several key persistent Legitimacy and Effectiveness issues which arise when private parties attempt antitrust enforcement through the courts. On key issues such as: (i) Compensation awards inadequacy; (ii) Lack of rights for indirect purchasers; (iii) Absence of a passing-on defence; and (iv) Limitations of collective litigation mechanisms, deficiencies arising in each of these four areas are identified and analysed. Pathways to reform are set out. Comparative analysis with the corresponding EU and US jurisprudence is undertaken throughout, to illuminate the contrast in treatment for antitrust litigants facing similar antitrust situations. Recently enacted reform legislation (AML 2022) does not remedy the antitrust protection concerns identified by the authors. Private parties seeking antitrust redress in China will therefore continue to have weaker remedies in antitrust enforcement cases, in contrast with their EU and US counterparts. The absence of comprehensive reform means that Legitimacy and Effectiveness deficiencies will continue to undermine legal protection for China’s private antitrust enforcement litigants. Furthermore, the research demonstrates how norm adoption on its own cannot raise the propect of better outcomes, unless accompanied by corresponding evolution in the provision of more robust enforcement rights and remedies for antitrust litigants, as well as evolution in judicial interpretation to support antitrust norms acceptance.
The Reliability of Patient-Performed Fecal Calprotectin Testing in Inflammatory Bowel Disease
Authors: Dijkhuis Lies E J L , Crouwel Femke , Duijvestein Marjolijn , Buiter Hans J C , de Boer Nanne K , Hamer Henrike M 
Published: December 2022

AbstractBackgroundHome use of a buffer-containing extraction device for fecal calprotectin determination can bypass the labor-intensive extraction procedure and potentially prevent degradation at room temperature.MethodsIn this prospective cross-sectional observational study, 2 CALiaGold tubes (extraction device) and one native tube were filled from the same bowel movement by patients with inflammatory bowel disease. Afterwards patients completed a questionnaire including whether they preferred the extraction device or the normal sampling method. All tubes were sent to the laboratory and when they arrived, 2 more CALiaGold tubes were filled at the laboratory from the native sample. The fecal calprotectin concentrations in all tubes were measured by a particle-enhanced turbidimetric immunoassay.ResultsFifty-three patients were included in the study. Fecal calprotectin levels were significantly higher in samples extracted by the patient compared to the analyst-performed extractions. When patients were divided into 3 groups (i.e., fecal calprotectin levels &lt;50 ug/g, 50 to 200 µg/g, and &gt;200 µg/g) a substantial concordance was found (Cohen kappa 0.654). Patients sampling imprecision was higher (P &lt; 0.018, median CV 16%) compared to the analyst. Most patients preferred this extraction device.ConclusionsPatient-performed fecal calprotectin extraction seems a realistic alternative sampling method and is preferred by most patients.
Understanding Forest Landowner Attitudes, Perceived Risk, and Response to Emerald Ash Borer in Kentucky
Authors: Adhikari Ram K , Poudyal Neelam C , Ochuodho Thomas O , Parajuli Rajan , Joshi Omkar , Mehmood Sayeed R , Munsell John F , Dhungel Gaurav , Thomas William , Crocker Ellen , Zhou Mo 
Published: December 2022

AbstractEmerald ash borer (EAB) (Agrilus planipennis), an invasive nonnative beetle, is responsible for the mortality of ash trees in the eastern and midwestern United States. Despite efforts to contain this beetle through various control options, human-induced spread of EAB has caused damage to ash forests in many states. Because most ash trees are under private ownership, it is important to understand how landowners evaluate the risk of EAB and perceive the effectiveness of various control options. A mail survey of private forest landowners was conducted in Kentucky in 2020 to assess their awareness and perception of various control options of EAB infestation. Results from this survey suggest that landowners are concerned about EAB and the associated increased risks, reduced quality of scenic views, and increased cleanup costs. Landowners experiencing EAB infestation believed that EAB management needs collective actions and that current efforts by government agencies are not sufficient. However, few landowners are taking actions themselves to manage EAB on their property. These findings shed light on the extent to which landowners are concerned about EAB impact and emphasize the need for development of effective control options and outreach programs to increase landowner engagement and actions in EAB control and management.
Environmental impacts on barley grain composition and longevity
Authors: Dufková Hana , Berka Miroslav , Psota Vratislav , Brzobohatý Břetislav , Černý Martin 
Published: December 2022

AbstractTo counter projected reductions in yields of the major crop barley, it is essential to elucidate the mechanisms of its resilience. To assist such efforts, we collected grains from plants grown in fields at 12 testing stations, with suitable temperature and precipitation gradients for identifying environmentally induced changes in their protein and metabolite contents. We then subjected the grains to detailed molecular analysis. The results showed that numerous metabolites and at least a quarter of the grain protein content was modulated by the environment, and provided insights into barley seed production under abiotic stress, including alterations in ribosomal proteins, heatshock protein 70 family proteins, inhibitors, storage proteins, and lipid droplet formation. Potential positive and negative markers of yield were also identified, including the phenolic compound catechin and storage protein levels, respectively. Complementary analyses of barley seedlings and Arabidopsis seeds, respectively, confirmed the role of the identified proteins in abiotic stress responses and highlighted evolutionarily conserved mechanisms. In addition, accelerated ageing experiments revealed that variations in the environment had stronger effects on seed longevity than the genotype. Finally, seeds with the highest longevity differed from the others in gibberellin contents, H2O2 metabolism, and levels of &gt;250 proteins, providing novel targets for improving resilience.
Accuracy and precision of triaxial orbit models I: SMBH mass, stellar mass, and dark-matter halo
Authors: Neureiter B , de Nicola S , Thomas J , Saglia R , Bender R , Rantala A 
Published: December 2022

ABSTRACT
We investigate the accuracy and precision of triaxial dynamical orbit models by fitting 2D mock observations of a realistic N-body merger simulation resembling a massive early-type galaxy with a supermassive black hole. We show that we can reproduce the triaxial N-body merger remnant’s correct black hole mass, stellar mass-to-light ratio and total enclosed mass (inside the half-light radius) for several different tested orientations with an unprecedented accuracy of 5–10 per cent. Our dynamical models use the entire non-parametric line-of-sight velocity distribution (LOSVD) rather than parametric LOSVDs or velocity moments as constraints. Our results strongly suggest that state-of-the-art integral-field projected kinematic data contain only minor degeneracies with respect to the mass and anisotropy recovery. Moreover, this also demonstrates the strength of the Schwarzschild method in general. We achieve the proven high recovery accuracy and precision with our newly developed modelling machinery by combining several advancements: (i) our new semiparametric deprojection code probes degeneracies and allows us to constrain the viewing angles of a triaxial galaxy; (ii) our new orbit modelling code SMART uses a 5-dim orbital starting space to representatively sample in particular near-Keplerian orbits in galaxy centres; (iii) we use a generalized information criterion AICp to optimize the smoothing and to compare different mass models to avoid biases that occur in χ2-based models with varying model flexibilities.
Evaluation of Methods to Detect Shifts in Directional Selection at the Genome Scale
Authors: Duchemin Louis , Lanore Vincent , Veber Philippe , Boussau Bastien 
Published: December 2022

AbstractIdentifying the footprints of selection in coding sequences can inform about the importance and function of individual sites. Analyses of the ratio of nonsynonymous to synonymous substitutions (dN/dS) have been widely used to pinpoint changes in the intensity of selection, but cannot distinguish them from changes in the direction of selection, that is, changes in the fitness of specific amino acids at a given position. A few methods that rely on amino-acid profiles to detect changes in directional selection have been designed, but their performances have not been well characterized. In this paper, we investigate the performance of six of these methods. We evaluate them on simulations along empirical phylogenies in which transition events have been annotated and compare their ability to detect sites that have undergone changes in the direction or intensity of selection to that of a widely used dN/dS approach, codeml’s branch-site model A. We show that all methods have reduced performance in the presence of biased gene conversion but not CpG hypermutability. The best profile method, Pelican, a new implementation of Tamuri AU, Hay AJ, Goldstein RA. (2009. Identifying changes in selective constraints: host shifts in influenza. PLoS Comput Biol. 5(11):e1000564), performs as well as codeml in a range of conditions except for detecting relaxations of selection, and performs better when tree length increases, or in the presence of persistent positive selection. It is fast, enabling genome-scale searches for site-wise changes in the direction of selection associated with phenotypic changes.
Five-year survivors from brain metastases treated with stereotactic radiosurgery: Biology, improving treatments, or just plain luck?
Authors: Pearce Jane B , Hsu Fang-Chi , Lanier Claire M , Cramer Christina K , Ruiz Jimmy , Lo Hui-Wen , Xing Fei , Smith Margaret , Li Wencheng , Whitlow Christopher , White Jaclyn J , Tatter Stephen B , Laxton Adrian W , Chan Michael D 
Published: December 2022

AbstractBackgroundImprovements in therapies have led to an increasing number of long-term survivors of brain metastases. The present series compares a population of 5-year survivors of brain metastases to a generalized brain metastases population to assess for factors attributable to long-term survival.MethodsA single institution retrospective review was performed to identify 5-year survivors of brain metastases who received stereotactic radiosurgery (SRS). A historical control population of 737 patients with brain metastases was used to assess similarities and differences between the long-term survivor population and the general population treated with SRS.ResultsA total of 98 patients with brain metastases were found to have survived over 60 months. No differences between long-term survivors and controls were identified with regards to the age at first SRS (P = .19), primary cancer distribution (P = .80), and the number of metastases at first SRS (P = .90). Cumulative incidence of neurologic death at 6, 8 and 10 years for the long-term survivor cohort was 4.8%, 16%, and 16% respectively. In the historical controls, cumulative incidence of neurologic death reached a plateau at 40% after 4.9 years. A significant difference in the distribution of burden of disease at the time of the first SRS was found between the 5-year survivors and the control (P = .0049). 58% of 5-year survivors showed no evidence of clinical disease at the last follow-up.ConclusionFive-year survivors of brain metastases represent a diverse histologic population, suggesting a small population of oligometastatic and indolent cancers exist for each cancer type.
Extensive gene flow in secondary sympatry after allopatric speciation
Authors: Wang Xinfeng , He Ziwen , Guo Zixiao , Yang Ming , Xu Shaohua , Chen Qipian , Shao Shao , Li Sen , Zhong Cairong , Duke Norman C , Shi Suhua 
Published: December 2022

Abstract
In the conventional view, species are separate gene pools delineated by reproductive isolation (RI). In an alternative view, species may also be delineated by a small set of ‘speciation genes’ without full RI, a view that has gained broad acceptance. A recent survey, however, suggested that the extensive literature on ‘speciation with gene flow’ is mostly (if not all) about exchanges in the early stages of speciation. There is no definitive evidence that the observed gene flow actually happened after speciation is completed. Here, we wish to know whether ‘good species’ (defined by the ‘secondary sympatry’ test) do continue to exchange genes and, importantly, under what conditions such exchanges can be observed. De novo whole-genome assembly and re-sequencing of individuals across the range of two closely related mangrove species (Rhizophora mucronata and R. stylosa) reveal the genomes to be well delineated in allopatry. They became sympatric in northeastern Australia but remain distinct species. Nevertheless, their genomes harbor ∼4000–10 000 introgression blocks averaging only about 3–4 Kb. These fine-grained introgressions indicate continual gene flow long after speciation as non-introgressable ‘genomic islets,’ ∼1.4 Kb in size, often harbor diverging genes of flower or gamete development. The fine-grained introgression in secondary sympatry may help settle the debate about sympatric vs. micro-allopatric speciation. In conclusion, true ‘good species’ may often continue to exchange genes but the opportunity for detection is highly constrained.
Increased All-cause Mortality in People With HIV and Comorbidities: Hepatitis B and C Virus Seropositivity and Hyperglycemia in Myanmar, 2005–2017
Authors: Kyaw Nang Thu Thu , Satyanarayana Srinath , Harries Anthony D , Kumar Ajay M V , Kyaw Khine Wut Yee , Phyo Khaing Hnin , Hayat Matthew J , Castro Kenneth G , Magee Matthew J 
Published: December 2022

Abstract

Background
Hepatitis C virus (HCV) and hepatitis B virus (HBV) coinfection are associated with increased mortality in people with HIV (PWH), and hyperglycemia is a common comorbidity in PWH. In this study, we used routinely collected clinical data to assess the associations between HBV and HCV seropositivity with all-cause mortality and whether this relationship differs by hyperglycemia status.

Methods
Eligible participants included adult PWH (≥15 years) who initiated antiretroviral therapy between May 2005 and June 2016 in Myanmar. HBV and HCV serostatus and hyperglycemia were measured at enrollment to HIV care using HBV surface antigen, HCV antibody tests, and random blood glucose (≥140 mg/dL), respectively.

Results
Among 27 722 PWH, 2260 (8%) were HBV seropositive, 2265 (9%) were HCV seropositive, 178 (0.6%) were HBV-HCV seropositive, and 1425 (5%) had hyperglycemia. During the median follow-up (interquartile range) of 3.1 (1.5–5.1) years, 3655 (13%) PWH died, and the overall mortality rate was 3.8 (95% CI, 3.7–3.9) per 100-person-years (PY). The mortality rate (per 100 PY) among PWH who were HBV seropositive was 4.6, among PWH who were HCV seropositive it was 5.1, and among PWH who were HBV-HCV seropositive it was 7.1. When stratified by glycemic status, the mortality rate was higher among patients with hyperglycemia compared with those with euglycemia (5.4 vs 4.0 per 100 PY), and the difference in mortality rate between patients with hyperglycemia and euglycemia was highest among those with HCV seropositivity (9.8 vs 5.0 per 100 PY).

Conclusions
Increased mortality rates associated with HBV and HCV seropositivity in PWH differed by their glycemic status. PWH with HCV seropositivity and hyperglycemia had the highest mortality rates.
Cyanobacterial photosystem II reaction center design in tobacco chloroplasts increases biomass in low light
Authors: Zhang Yuan , Ananyev Gennady , Matsuoka Aki , Dismukes G Charles , Maliga Pal 
Published: December 2022

AbstractThe D1 polypeptide of the photosystem II (PSII) reaction center complex contains domains that regulate primary photochemical yield and charge recombination rate. Many prokaryotic oxygenic phototrophs express two or more D1 isoforms differentially in response to environmental light needs, a capability absent in flowering plants and algae. We report that tobacco (Nicotiana tabacum) plants carrying the Synechococcus (Synechococcus elongatus PCC 7942) low-light mutation (LL-E130Q) in the D1 polypeptide (NtLL) acquire the cyanobacterial photochemical phenotype: faster photodamage in high light and significantly more charge separations in productive linear electron flow in low light. This flux increase produces 16.5% more (dry) biomass under continuous low-light illumination (100 μE m−2 s−1, 24 h). This gain is offset by the predicted lower photoprotection at high light. By contrast, the introduction of the Synechococcus high-light mutation (HL-A152S) into tobacco D1 (NtHL) has slightly increased photoprotection, achieved by photochemical quenching, but no apparent impact on biomass yield compared to wild type under the tested conditions. The universal design principle of all PSII reaction centers trades off energy conversion for photoprotection in different proportions across all phototrophs and provides a useful guidance for testing in crop plants. The observed biomass advantage under continuous low light can be transferred between evolutionarily isolated lineages to benefit growth under artificial lighting conditions. However, removal of the selective marker gene was essential to observe the growth phenotype, indicating growth penalty imposed by use of the particular spectinomycin-resistance gene.
NIR-II live imaging study on the degradation pattern of collagen in the mouse model
Authors: Li Huizhu , Meng Xinxian , Sheng Huaixuan , Feng Sijia , Chen Yuzhou , Sheng Dandan , Sai Liman , Wang Yueming , Chen Mo , Wo Yan , Feng Shaoqing , Baharvand Hossein , Gao Yanglai , Li Yunxia , Chen Jun 
Published: December 2022

Abstract
The degradation of collagen in different body parts is a critical point for designing collagen-based biomedical products. Here, three kinds of collagens labeled by second near-infrared (NIR-II) quantum dots (QDs), including collagen with low crosslinking degree (LC), middle crosslinking degree (MC) and high crosslinking degree (HC), were injected into the subcutaneous tissue, muscle and joints of the mouse model, respectively, in order to investigate the in vivo degradation pattern of collagen by NIR-II live imaging. The results of NIR-II imaging indicated that all tested collagens could be fully degraded after 35 days in the subcutaneous tissue, muscle and joints of the mouse model. However, the average degradation rate of subcutaneous tissue (k = 0.13) and muscle (k = 0.23) was slower than that of the joints (shoulder: k = 0.42, knee: k = 0.55). Specifically, the degradation rate of HC (k = 0.13) was slower than LC (k = 0.30) in muscle, while HC showed the fastest degradation rate in the shoulder and knee joints. In summary, NIR-II imaging could precisely identify the in vivo degradation rate of collagen. Moreover, the degradation rate of collagen was more closely related to the implanted body parts rather than the crosslinking degree of collagen, which was slower in the subcutaneous tissue and muscle compared to the joints in the mouse model.
Finding Fortune: How Do Institutional Investors Pick Asset Managers?
Authors: Brown Gregory W , Gredil Oleg R , Kantak Preetesh 
Published: December 2022

Abstract
We propose and test a framework of private information acquisition and decision timing for asset allocators hiring outside investment managers. Using unique data on due diligence interactions between an institutional allocator and 860 hedge fund managers, we find that the production of private information complements public information. The allocator strategically chooses how much proprietary information to collect, reducing due diligence time by 18 months and improving outcomes. Funds selected by the manager outperform those not selected by 9$\%$ over 20 months. The outperformance relates to the allocator learning about fund return-to-scale constraints and manager skill before other investors.
Patients’ and parents’ satisfaction to improve patient care in JIA: factors determining acceptable symptom state measured with JAMAR
Authors: Del Giudice Emanuela , de Roock Sytze , Vastert Sebastiaan J , Wulffraat Nico M , Swart Joost F , van Dijkhuizen Evert H P 
Published: December 2022

Abstract

Objectives
The aim of this study was to identify factors associated with patients’ and parents’ reported satisfaction with JIA care, measured with the juvenile arthritis child and parent acceptable symptom state (JA-CASS and JA-PASS, respectively).

Methods
A prospective cohort of 239 JIA patients and 238 parents in a tertiary centre who completed the juvenile arthritis multidimensional assessment report (JAMAR) was analysed cross-sectionally. The primary outcomes were positive JA-CASS and JA-PASS, respectively. Items in the JAMAR, as well as JIA subtype, demographics, and disease activity parameters, were analysed in univariate analysis. A multivariable logistic regression analysis was used to build models explaining the variance of the primary outcome as a dependent variable.

Results
According to the JAMAR, 141 (59.0%) of 239 patients and 149 (62.6%) of 238 parents were satisfied with their or their child’s current condition. For patients, the determinants in the final model were a shorter duration of morning stiffness (P = 0.001), a lower age at disease onset (P = 0.044), a longer disease duration (P = 0.009) and a higher rating of the patient’s well-being measured on a visual analogue scale (VAS) (P = 0.004). For parents, the determinants were the current state of disease activity (current state of persistent activity P = 0.002, relapse P &lt; 0.005), problems at school (P = 0.002) and the items regarding quality of life (QoL) (P = 0.005).

Conclusion
Our data highlight the importance of patients’ and parents’ opinions in the evaluation of disease activity, and support their integration into the shared decision-making in daily clinical practice to improve the quality of medical care.