bluuebunny/crossref_metadata_2025_split huggingface dataset:
Working with families of adults affected by eating disorders: uptake, key themes, and participant experiences of family involvement in outpatient treatment-as-usual
Authors: Fleming Carmel , Byrne Jacqueline , Healy Karen , Le Brocque Robyne 
Published: June 2022

AbstractBackgroundEating disorders are associated with significant personal and family costs. Clinical guidelines recommend family members be involved and supported during care, but little has been reported regarding the preferences of adults around carer involvement in treatment. The necessary intensity of family work with adults is also unknown. A trial of a standardised brief family involvement method was conducted in an adult eating disorder service offering treatment-as-usual. Uptake and feasibility of implementing the approach as part of standard outpatient care and the preliminary impact on issues identified by adult patients and carers were evaluated.MethodsEligible referrals at an adult eating disorders outpatient clinic were offered as needed family consultation to address presenting interpersonal problems identified by patients and their family members, and outcomes were evaluated 4 weeks later. Pre and post intervention surveys identified participant self-reported change in (i) problem frequency, (ii) distress and disruption caused, and (iii) confidence regarding presenting problems. Open text responses provided an overview of patient and carer goals for family involvement and revealed how the novel method impacted these areas as well as overall experience of, and feedback regarding, the brief family intervention.ResultsTwenty-four female participants aged 18–53, and 22 carers participated in 31 consultations. Common concerns raised were eating disorder related interpersonal and communication issues. The focused sessions, offered on a one-at-a-time basis, showed preliminary effectiveness for reducing both patients and carer concerns. For example, adult patients reported that life interference from interpersonal problems was lower and confidence to deal with them was higher following family consultation. Carers also reported that frequency, level of worry, and life interference around presenting problems were lower after the structured family intervention.ConclusionsBrief family consultation, with a single focus on issues identified by family members and adult patients, was a safe and feasible procedure with adults affected by eating disorders. Effective at meeting the needs of participants, the framework investigated in the current study may also be a useful direction for adult services to consider when looking to support families and meet recommendations for their routine involvement in the outpatient care.Trial registration: Australian Clinical Trials Register number: ACTRN12621000047897 (www.anzctr.org.au).
Interpersonal predictors of loneliness in Japanese children: variable- and person-centered approaches
Authors: Nishimura Takuma , Murakami Tatsuya , Sakurai Shigeo 
Published: June 2022

AbstractBackgroundLoneliness in children has been a major topic of interest in both clinical and developmental psychology. Further studies to investigate predictors of loneliness are needed for educational practices.MethodsA total of 1088 late elementary school-aged children (48.81% boys, Mage = 10.35) participated in a 1-year longitudinal survey. We used hierarchical linear modeling and mover-stayer latent transition analysis.DiscussionFindings from the variable- and person- centered approaches suggested that less positive peer relations, higher victimization, and higher relational aggression are predictors of higher future loneliness. Meanwhile, both approaches did not reach an agreement concerning predictors to reduce loneliness. This result highlighted a utility of a combined approach and sounded an alarm for overreliance on the variable-centered approach dominating child research.ConclusionTo protect young children from loneliness, it will be more beneficial to prevent the development of loneliness rather than to apply interventions to reduce loneliness once established. Preventive practices need to be implemented to protect children from loneliness.
A 30,000-km journey by Apus apus pekinensis tracks arid lands between northern China and south-western Africa
Authors: Zhao Yanyan , Zhao Xinru , Wu Lan , Mu Tong , Yu Fang , Kearsley Lyndon , Liang Xuan , Fu Jianping , Hou Xiaoru , Peng Peng , Li Xiaoyang , Zhang Tao , Yan Su , Newell Dick , Hewson Chris M. , Townshend Terry , Åkesson Susanne , Liu Yang 
Published: June 2022

Abstract
Background
As a widely distributed and aerial migratory bird, the Common Swift (Apus apus) flies over a wide geographic range in Eurasia and Africa during migration. Although some studies have revealed the migration routes and phenology of European populations, A. a. apus (from hereon the nominate apus), the route used by its East Asian counterpart A. a. pekinensis (from hereon pekinensis) remained a mystery.

Methods
Using light level geolocators, we studied the migration of adult pekinensis breeding in Beijing from 2014 to 2018, and analysed full annual tracks obtained from 25 individuals. In addition, we used the mean monthly precipitation to assess the seasonal variations in humidity for the distribution ranges of the nominate apus and pekinensis. This environmental variable is considered to be critically relevant to their migratory phenology and food resource abundance.

Results
Our results show that the swifts perform a round-trip journey of ca 30,000 km each year, representing a detour of 26% in autumn and 15% in spring compared to the shortest route between the breeding site in Beijing and wintering areas in semi-arid south-western Africa. Compared to the nominate apus, pekinensis experiences drier conditions for longer periods of time. Remarkably, individuals from our study population tracked arid habitat along the entire migration corridor leading from a breeding site in Beijing to at least central Africa. In Africa, they explored more arid habitats during non-breeding than the nominate apus.

Conclusions
The migration route followed by pekinensis breeding in Beijing might suggest an adaptation to semi-arid habitat and dry climatic zones during non-breeding periods, and provides a piece of correlative evidence indicating the historical range expansion of the subspecies. This study highlights that the Common Swift may prove invaluable as a model species for studies of migration route formation and population divergence.
Sulphite addition during steam pretreatment enhanced both enzyme-mediated cellulose hydrolysis and ethanol production
Authors: Zhong Na , Chandra Richard , Yamamoto Minna , Leskinen Timo , Granström Tom , Saddler Jack 
Published: June 2022

AbstractSulphite addition during steam pretreatment of softwoods under acidic, neutral and alkaline conditions was assessed to try to minimize lignin condensation. Although pretreatment under neutral/alkaline conditions resulted in effective lignin sulphonation, non-uniform size reduction was observed. In contrast, acidic sulphite steam treatment at 210 °C for 10 min resulted in homogenous particle size reduction and water-insoluble component that was 62% carbohydrate and 33% lignin. This carbohydrate-rich substrate was readily hydrolyzed and fermented which indicated the lack of fermentation inhibitors in the steam-pretreated whole slurry. The use of high solid loading (25% w/v) resulted in a hydrolysis yield of 58% at an enzyme loading of 40 mg protein/g glucan and efficient fermentation (46.6 g/L of ethanol). This indicated that the addition of acidic sulphite at the steam pretreatment of softwoods improved both the enzymatic hydrolysis and fermentation of steam-pretreated whole slurries.Graphical Abstract
Practices of patient engagement in drug development: a systematic scoping review
Authors: Zvonareva Olga , Craveț Constanța , Richards Dawn P. 
Published: June 2022

Abstract
Background
During the past decade, patient engagement (PE) has attracted significant attention in the field of drug development. Readiness to accept the central importance of patients’ knowledge and contributions has become evident. This study aimed to synthesize evidence on the current state of PE in drug development: what is actually being done and how.

Methods
A systematic scoping review was conducted based on a PRISMA-informed protocol. Search was performed in PubMed, EMBASE and Web of Science, covering the period between 2011 and 2021. For analysis of extracted data, we developed a framework for analyzing PE in Drug Development. The Framework distinguishes a number of different PE types that take place at different stages of drug development and are characterized by the different degrees of power patients have in the process. It allowed us to assess depth and intensity of PE initiatives included in this review.

Results
Most included PE initiatives took place at the stage of designing studies (40 in total). At this stage drug development goals are already set, but the mode of reaching them has not yet been fully determined. PE initiatives on the finetuning details stage followed (16 in total). The finetuning details stage covers the last parts of the drug development trajectory, when only relatively minor issues are still open for patients’ contributions. The least numerous were PE initiatives on the stage of setting up R&D program (13 in total). This stage refers to the early steps in drug development where PE has the potential to make the most impact on shaping the subsequent process. In terms of intensity of engagement, most PE initiatives included in this review align with consultation and involvement types, 26 and 30 initiatives, respectively. Partnership was less frequent in the published accounts of PE (13 initiatives).

Conclusions
This review delineated a contemporary landscape of PE in drug development. Although attention to PE in drug development is relatively recent, a wide range of PE practices has already been initiated. The results indicate the necessity of distinguishing between different types of PE in order to understand consequences of choices regarding depth and intensity of PE.
Malignancy in ankylosing spondylitis: a cross-sectional analysis of a large population database
Authors: Bittar Mohamad , Merjanah Sali , Alkilany Reem , Magrey Marina 
Published: June 2022

Abstract
Background
Increased cancer-risk has been reported with rheumatoid arthritis and systemic lupus erythematosus, but the risk is poorly studied in ankylosing spondylitis (AS). Conflicting data in AS have been reported in Asia and Europe, with lack of US population-based studies. Our objective is to study the prevalence of cancer in patients with AS in the US.

Methods
Using the Explorys database, we performed a cross-sectional study. Data from AS patients and controls were stratified by 2 rheumatology visits, age groups, clinical characteristics, and frequency of cancers. The data were analyzed using a series of chi-square tests of independence as well as logistic regression to test for association between AS and cancer.

Results
1410 AS patients (12.88%) had cancer. Female AS patients had a lower prevalence of cancer compared to controls (OR 0.840, 95% CI [0.769, 0.916]), while male AS patients had no statistically significant difference (OR 1.011, 95% CI [0.929, 1.099]). Among patients with AS, Skin cancers (squamous cell, malignant melanoma, and basal cell) and head and neck cancers were significantly increased.

Conclusion
Our study demonstrated that the prevalence of “any-type-cancer” was not increased in AS patients compared to controls with no rheumatic disease. Skin, head, and neck cancers were more frequently seen in AS patients.
Efficacy of single and combined applications of entomopathogenic fungi and nematodes against the pupae of colorado potato beetle (Leptinotarsa decemlineata [Say]), (Coleoptera: Chrysomelidae)
Authors: Uzun Yiğit Asiye , Göze Özdemir Fatma Gül , Demirözer Ozan , Nayır Tufan 
Published: June 2022

Abstract
Background
The lethal effects of different entomopathogenic fungi (EPF) and nematodes (EPN) on the pupae of the Colorado Potato Beetle, Leptinotarsa decemlineata (Say) (Coleoptera: Chrysomelidae) were investigated in a two-step study when used separately or together. In the first step, Nostalgist (Beauveria bassiana strain Bb-1, Agrobest Co.), Steinernema feltiae (Filipjev) (Rhabditida: Steinernematidae), Heterorhabditis bacteriophora Poinar, 1976 (Rhabditida: Heterorhabditidae) (Bioglobal Co.), 2 Turkish isolates of Beauveria bassiana BIM-001 and BY2 were applied separately to the pupal stage of pest in the soil. In the experiments, 3 different concentrations (150, 200, and 250 million infective juveniles (IJs)/100 l water) of EPN and a single concentration (1x108 spores/ml for and maximum recommended field dose 1 × 108 CFU/ml) of EPF were used. In the second step, BIM-001 and BY2 isolates of B. bassiana were combined with both EPN species; S. feltiae + B. bassiana BIM-001, S. feltiae + B. bassiana BY2, H. bacteriophora + B. bassiana BIM-001, H. bacteriophora +B. bassiana BY2 were applied to pupae. At this stage, 150 million IJs/100 l water which was the maximum recommended field concentration for EPN and 1 × 108 spores/ml for local EPF isolates were used.

Results
According to the study results, pupae deaths were significantly higher in Nostalgist (74%) than those of B. bassiana BIM-001, B. bassiana BY2, S. feltiae, and H. bacteriophora (P<0.05). While both EPN caused higher mortality than B. bassiana BY2, B. bassiana BIM-001 had the highest mortality rates. The combination of S. feltiae + B. bassiana BIM-001 at the highest mortality rate (80%) was found statistically different and significant from other EPF + EPN treatments on pupae. Moreover, there were non-statistical differences between the other EPF and EPN combinations.

Conclusion
It was found that the combined use of EPF and EPN was more effective on the pupae of L. decemlineata than a single application. According to the results of the study, it may be promising to use EPN and EPF together for the control of the Colorado Potato Beetle pupae.
Optimization of phenol adsorption from synthetic wastewater by synthesized BiFeO3 perovskite material, using split-plot central composite design
Authors: Garba Zaharaddeen Nasiru , Ekwumemgbo Patricia Adamma , Stephen Godwill 
Published: June 2022

Abstract
Background
Optimization of adsorption processes using statistical methods of experiment for the removal of pollutants from wastewater, in an effort to curb the global problem of water pollution, is increasingly being adopted because it is cost-effective and time-saving. In most cases, standard central composite designs (CCDs) are often employed for the optimization processes, where the experimental variables are often randomized completely. However, most experiments especially within the industries often involve factors with some hard-to-change (HTC) levels and some with easy-to-change (ETC) levels, in which case the HTC factor cannot be completely randomized, and this challenge can only be overcome by the use of a split-plot CCD. However, there is scarcity of literature on the use of split-plot CCD for the optimization of adsorption processes, and hence in this study, the prime conditions for the removal of phenol onto BiFeO3 from synthetic wastewater were studied. The effect of three adsorption variables (pH, adsorbent dosage, and shaking time) was investigated using split-plot CCD. pH was considered as the HTC factor due to the amount of time, acid and/or base required to change it, while the adsorbent dosage and contact time were the ETC factors. Quadratic model was developed for the phenol percentage removal.

Results
The optimum adsorption conditions obtained from the study were adsorbent dosage of 0.60 g, pH of 7 as well as contact time of 167 min with desirability of 1. The predicted and experimental values obtained were 89.73 and 89.21%, showing good agreement between the experimental value and those predicted by the quadratic model. Langmuir isotherm model was found to be the best fit for the equilibrium adsorption data giving rise to monolayer adsorption capacity of 106.50 mg/g. The pseudo-second-order kinetic model’s correlation coefficient (R2) was higher than that of the pseudo-second-order kinetic suggesting the applicability of the model to the adsorption of phenol.

Conclusions
The synthesized BiFeO3 could be considered as a viable alternative to the expensive commercial activated carbon for the removal of phenols in wastewater, and the use of split-plot CCD model makes the experiment much easier to run and save time and/or cost due to fewer number of runs and restriction in the randomization of HTC factors.
A combined 2-D and 3-D QSAR modeling, molecular docking study, design, and pharmacokinetic profiling of some arylimidamide-azole hybrids as superior L. donovani inhibitors
Authors: Ugbe Fabian Audu , Shallangwa Gideon Adamu , Uzairu Adamu , Abdulkadir Ibrahim 
Published: June 2022

Abstract
Background
Leishmaniasis is one of the neglected tropical diseases which is prevalent in the tropical regions of the world most especially in Africa. It is caused by the Leishmania species and transmitted to humans majorly through the bite of the female sandfly. This study was carried out in support of the continuous search for new drug molecules effective enough for the treatment of leishmaniasis, and which have very limited side effects. This study was focused on a combined 2-D and 3-D QSAR modeling of thirty-six arylimidamide-azole hybrids, molecular docking study, design, and pharmacokinetic analysis of some selected and newly designed arylimidamide-azole analogs. The density functional theory (DFT) with B3LYP and 6-31G** basis set was employed for the geometry optimization of the various compounds. Genetic function approximation (GFA) and multi-linear regression (MLR) approaches were used for the 2-D QSAR model building, while the fractional factorial design (FFD) and uninformative variable elimination-partial least square (UVEPLS) were employed for building the 3-D QSAR model. Pyridoxal kinase (PdxK) receptor (PDB: 6K91) was the target protein of interest in this study.

Results
The built 2-D and 3-D QSAR models were found to satisfy the requirement of both internal and external validation tests as follows: 2-D QSAR; R2 = 0.9614, R2adj = 0.9513, Q2cv = 0.9350, R2test = 0.6766 and cRp2 = 0.8779, and for 3-D QSAR (UVEPLS at PC = 5); R2 = 0.9839, Q2LOO = 0.7539 and Q2LTO = 0.7367. The CoMFA steric and electrostatic field contributions were 68.96% and 31.04%, respectively. All the designed analogs showed higher predicted activities than that of the template (36). Also, the new compounds showed higher binding affinities (MolDock scores) than that of the reference drug pentamidine (− 141.793 kcal/mol), with 36e showing the highest negative MolDock score of − 208.595 kcal/mol. Additionally, these newly designed compounds were said to be orally bioavailable (excluding 36f and 36g that violated 2 of the Lipinski’s provisions), with perfect intestinal absorption, less difficult to synthesize, AMES toxicity free, and showed strong interactions with the target.

Conclusions
The newly designed compounds especially 36e have shown a marked pharmacological improvement over the template molecule and are therefore recommended for further practical evaluation as superior pyridoxal kinase inhibitors.
The prevalence of ultra-low total IgE level among Egyptian population: impact of age, sex, and socioeconomic class
Authors: Mohamed Manar F. , Gwad Asmaa M. Abd El , Sallam Dina E. , Afifi Amira H. , Abdalgeleel Shaimaa A. , Moustafa Nouran M. , Abougabal Maged T. , Taha Sara I. , El-Moussely Lamiaa M. 
Published: June 2022

Abstract
Background
Immunoglobulin E (IgE) is the least prevalent antibody type; it plays a key role in host immunity against parasitic infections and allergic diseases. Association between IgE deficiency and higher malignancy rates has been suggested in many studies.

Objectives
The goal of our study was to determine the prevalence of ultra-low total IgE levels and their variations according to sex and age among the Egyptian population.

Methodology
This multicenter retrospective cross-sectional study included serum total IgE and CBC records of 1099 children and 993 adults recruited from private and public hospitals in Egypt between 2015 and 2021. Total IgE levels were classified into ultra-low, normal, high, and very high.

Results
Of all included subjects, 0.8% had ultra-low IgE levels and 74.4% had normal IgE levels. High and very high serum total IgE levels were 24.1% and 0.7%, respectively. IgE levels were significantly higher among adults than children 45 (16.5–113.25) IU/ml vs. 20 (10–75) IU/ml; p < 0.001and among private hospital’s patients than the public one (40 (15–98.4) IU/ml vs. 25 (10–98.4) IU/ml; p = 0.002. No significant difference between total IgE serum levels regarding gender (p = 0.825). Total IgE levels were higher among young adults, with a gradual decline among older patients and a peak among the 50 s and 60 s patients. Pearson correlation between IgE and absolute eosinophilic count showed positive correlation but did not reach significant level r = 0.04, p = 0.367.

Conclusion
Age and socioeconomic class have impacts on total IgE levels with a relatively low prevalence of ultra-low IgE among the Egyptian population.
Improving vehicle’s seismic safety by equipping railway bridges with FPB and misalignment control device
Authors: Jin Zhibin , Chen Ke , He Jinzhe 
Published: June 2022

AbstractRunning safety of the railway vehicles on the bridge during earthquakes is a major concern for railway engineering. To reduce the derailment risk of railway vehicles on bridges, friction pendulum bearings (FPB) are proposed to be equipped on simply supported bridges in this study. The full nonlinear behavior of the FPB is introduced into the vehicle-bridge interaction model. The effect of FPB’s manufacturing variations, including the shear pin’s strength and friction coefficient, on the misalignment was investigated. The manufacturing variations of the FPB were found to produce large lateral misalignment, which further contributes to large wheel-rail forces when the vehicle passes over the girder ends. It diminishes the improvement in the vehicle’s seismic safety provided by FPBs. Thus, a misalignment control device is proposed to limit the misalignment of the railway bridges equipped with FPBs. The vehicle-bridge interaction analysis results show that no wheel uplift occurred on the bridge equipped with FPBs and misalignment control devices during an earthquake. It indicates that the FPB significantly reduces the vehicle’s derailment risk on bridges compared with the non-isolated bearings.