bluuebunny/crossref_metadata_2025_split huggingface dataset:
Concurrent aspergillosis and cystic pulmonary metastases in a patient with tongue squamous cell carcinoma
Authors: Su Hung-Chieh , Liao Che-Chi , Chen Chieh-Lung , Liao Wei Chih , Cheng Wen-Chien 
Published: July 2022

Abstract
Pulmonary Aspergillus infection may have a variety of manifestations depending on the patients’ immunity status and pre-existing lung conditions. Radiographically, aspergilloma, which is usually associated with noninvasive Aspergillus fumigatus conidia, may feature a characteristic mass in a cavity commonly located in the upper lobes of the lung. It is typically encountered upon pre-existing lung damage. Here we report Aspergillus growing in a pulmonary metastatic cavity in a 47-year-old male worker with a history of tongue cancer after a radical operation with neck dissection and concurrent chemotherapy in 2014. Chest radiography and computed tomography showed a cavitary lesion with a ball-in-hole lesion in the right upper lobe (RUL) and two cystic lesions within the bilateral upper lung field. Endobronchial ultrasound-guided transbronchial biopsy (EBUS-TBB) from the RUL anterior segmental bronchus (RB3) revealed the presence of Aspergillus conidia and squamous cell carcinoma. Wedge resection of the cystic lesion within the left upper lobe confirmed the diagnosis of metastatic squamous cell carcinoma. This is a rare case of aspergillosis within cavities of pulmonary metastases in a patient who was diagnosed with tongue squamous cell carcinoma. The conclusive distinction between neoplasm and fungal infection is difficult to achieve by radiography, and a pathological biopsy by EBUS-TBB is necessary to aid diagnosis. Clinicians should be aware of such an atypical presentation of metastases coexisting with Aspergillus infection.
Determination of prior austenite grain-and martensitic substructure size from metallographic etchings using a multi-step image processing algorithm
Authors: Hönigmann T. , Brandl D. , Stockinger M. , Gruber C. , Frois F. , Ressel G. 
Published: July 2022

Abstract
State-of-the-art modelling algorithms allowing for prediction of macroscopic properties of martensitic steels are primarily based on microstructural parameters such as prior austenite grain size as well as martensite packet-and block size distribution. The latter are usually obtainable via electron backscatter diffraction (EBSD) measurements. However, determination via light microscopy would present a more cost-effective determination method. This work presents a python-based multi-step image processing algorithm capable of separating the grain boundaries and the martensitic substructure from etched micrographs. Additionally, the viability of a characteristic mean free path parameter λ of the martensitic substructure for comparison of different martensitic microstructures is tested. To this end, a microstructure variation of PH15-5 was performed using different heat treatments and the specimens were analyzed using EBSD and electrolytically etched micrographs.
Interoceptive accuracy does not predict emotion perception in daily life
Authors: Pohl Anna , Dummel Sebastian , Bothur Mascha , Gerlach Alexander L. 
Published: July 2022

Abstract
Peripheral emotion theories suggest a crucial role of interoception for emotion perception, which in turn facilitates emotion regulation. Laboratory studies found positive relations between interoceptive accuracy and perceived emotion intensity and arousal. Studies in natural settings are largely missing, but seem important by virtue of emotional experience and regulation diversity.
On hundred seven participants underwent a cardiovascular interoceptive accuracy task. Afterwards, participants provided detailed information on perceived emotions and emotion regulation strategies in an ecological momentary assessment (EMA). Multilevel models were calculated. In consideration of valence, emotion intensity, arousal, intensity of body sensations and, emotion regulation success were modeled as a function of centered interoceptive accuracy.
Interoceptive accuracy did not predict any emotion perception criterion. Lower accuracy was related to a slightly stronger decrease of perceived arousal after regulation.
Differences in emotion categories, intensity, and sample collection might explain divergences to laboratory studies.
Alternative analytical methods for ibrutinib quantification in pharmaceutical formulation: A statistical comparison
Authors: Akbel Erten , Güngör Serdar , Bulduk İbrahim 
Published: July 2022

Abstract
Ibrutinib is a drug used for the treatment of marginal zone lymphoma, mantle cell lymphoma, lymphocytic leukemia, chronic graft, and Waldenstrom macroglobulinemia. A simple, sensitive, and fast liquid chromatographic and spectrophotometric method for the quantification of ibrutinib in pharmaceutical forms and bulk was developed and validated. The chromatographic technique was developed using an ODS 3 C 18 (250 mm × 4.6 mm i.d., 5 µm) column. The mobile phase was a mixture of 0.1% trifluoroacetic acid in water and acetonitrile (50/50, v/v) at a flow rate of 1.0 mL·min−1. Eluent detection was carried out at a wavelength of 260 nm using a ultraviolet detector. The retention time of ibrutinib was found to be 5.27. On the other hand, Ibrutinib was determined using a spectrophotometric technique by measuring the absorbance of the solutions at a wavelength of 260 nm. The developed techniques were validated in accordance with the protocols outlined in International conference on harmonisation of technical requirements for registration of pharmaceuticals for human (ICH) guidelines Q2(R1). Correlation coefficients for both methods were greater than 0.999 in the concentration range of 5–30 mg·mL−1. The relative standard deviation values were low in intraday and interday precision tests. The accuracy of the developed techniques ranged 99.74–100.23% for the chromatographic method and 99.32–100.76% for the spectrophotometric method. The limits of detection and quantitation were 0.90 and 2.80 µg·mL−1 for the chromatographic method and 1.10 and 3.20 µg·mL−1 for the spectrophotometric method. The developed and validated analytical methods can be safely used in quality control tests for the determination of the amount of ibrutinib in pharmaceutical products.
Prescription patterns and predictors of unmet pain relief in patients with difficult-to-treat osteoarthritis in the Nordics: analyses from the BISCUITS study
Authors: Arendt Nielsen Lars , Schepman Patricia , Hygge Blakeman Karin , Wilhelm Stefan , Robinson Rebecca , Beck Craig , Liseth Hansen Johan , Rolfson Ola 
Published: July 2022

Abstract

Objectives
Osteoarthritis (OA) is one of the leading causes of disability worldwide. Pain is the most important symptom in OA, driving medical care, disability, reduced functionality, and decreased quality of life. The objective of this study was to describe prescription patterns of difficult-to-treat OA and explore possible predictors of unmet pain relief in Nordic patients.

Methods
This observational cohort study included patients with a confirmed diagnosis of OA (index date) in specialty care in Sweden, Norway, Finland and Denmark between 1 January 2011 and 31 December 2012 who were followed for up to 5 years. Four subgroups were pre-defined to characterize difficult-to-treat OA: (1) ≥2 chronic comorbidities in the 3-year pre-index period; (2) top 10% of healthcare resource users, 1-year post-index; (3) ≥3 types of prescription pain medications during pre-index period to first year post-index, with ≥30 days between types; (4) having a contraindication to a nonsteroidal anti-inflammatory drug (NSAID). Patient characteristics, prescription patterns and predictors of unmet pain relief (defined as persistent opioid use, using several types of opioids or long-term NSAID use) were analyzed.

Results
We identified 288,174 OA patients and the average age was 63.5 years at time of diagnosis and 58% of them were female. After 5 years, 35–50% of the patients defined as ‘difficult-to-treat’ had ≥1 prescription of opioids, compared to 20–25% of all OA patients (p-value <0.05). Comorbidities and disability pension were strong predictors of unmet pain relief (p-value <0.001).

Conclusions
This study shows a substantial use of pain medications (NSAID and opioids) in difficult-to-treat OA patients. These findings suggest that pain may be inadequately managed in a considerable number of patients with OA, particularly those with contraindications to an NSAID. A high comorbid and socioeconomic burden are relevant risk factors among patients who continue to use opioids for a long period of time.
Burden of disease and management of osteoarthritis and chronic low back pain: healthcare utilization and sick leave in Sweden, Norway, Finland and Denmark (BISCUITS): study design and patient characteristics of a real world data study
Authors: Hallberg Sara , Rolfson Ola , Karppinen Jaro , Schiøttz-Christensen Berit , Stubhaug Audun , Rivano Fischer Marcelo , Gerdle Björn , Toresson Grip Emilie , Gustavsson Anders , Robinson Rebecca L , Varenhorst Christoph , Schepman Patricia 
Published: July 2022

Abstract

Objectives
Osteoarthritis (OA) and chronic low back pain (CLBP) are common musculoskeletal disorders with substantial patient and societal burden. Nordic administrative registers offer a unique opportunity to study the impact of these conditions in the real-world setting. The Burden of Disease and Management of Osteoarthritis and Chronic Low Back Pain: Health Care Utilization and Sick Leave in Sweden, Norway, Finland and Denmark (BISCUITS) study was designed to study disease prevalence and the societal and economic burden in broad OA and CLBP populations.

Methods
Patients in Sweden, Norway, Finland and Denmark with diagnoses of OA or CLBP (low back pain record plus ≥2 pain relief prescriptions to indicate chronicity) were identified in specialty care, in primary care (Sweden and Finland) and in a quality-of-care register (Sweden). Matched controls were identified for the specialty care cohort. Longitudinal data were extracted on prevalence, treatment patterns, patient-reported outcomes, social and economic burden.

Results
Almost 1.4 million patients with OA and 0.4 million with CLBP were identified in specialty care, corresponding to a prevalence in the Nordic countries of 6.3 and 1.9%, respectively. The prevalence increased to 11–14% for OA and almost 6% for CLBP when adding patients identified in primary care. OA patients had a higher Elixhauser comorbidity index (0.66 vs. 0.46) and were using opioids (44.7 vs. 10.2%) or long-term nonsteroidal anti-inflammatory drug (NSAIDs) (20.9 vs. 4.5%) more than four times as often as compared to controls. The differences were even larger for CLBP patients compared to their controls (comorbidity index 0.89 vs. 0.39, opioid use 77.7 vs. 9.4%, and long-term NSAID use 37.2 vs. 4.8%).

Conclusions
The BISCUITS study offers an unprecedented, longitudinal healthcare data source to quantify the real-world burden of more than 1.8 million patients with OA or CLBP across four countries. In subsequent papers we aim to explore among others additional outcomes and subgroups of patients, primarily those patients who may benefit most from better healthcare management.
Asymptotic properties of duration-based VaR backtests
Authors: Malecka Marta 
Published: July 2022

Abstract
To increase the power of the VaR tests, it has been recently proposed to extend the duration-based test class with the geometric-VaR and Gini-coefficient-based tests.
These tests, though exhibiting outstanding power properties, have not gained recognition in the industry.
A potential reason is the absence of ready-to-use statistical distributions.
To remedy this, we inquire into the limiting properties of these tests and derive relevant asymptotic distributions.
We also provide a generalized geometric-VaR test and give its distribution.
Through the Monte Carlo study, we show the accuracy of our asymptotic procedures in finite samples, and we find these procedures to be relevant for the current Basel standards.
Our theoretical results are illustrated by the empirical study that includes data from the current COVID-19 crisis.
A Quality Improvement Approach to Enhance LGBTQ+ Inclusivity in Pediatric Primary Care
Authors: McKinnish Tyler , Hunt Candice , Weinberg Steven , Perry Martha , Seashore Carl , Gold Stuart , Vander Schaaf Emily B. 
Published: July 2022

BACKGROUND
Lesbian, gay, bisexual, transgender, and queer (LGBTQ+) teens are at higher risk of illness as a result of bias but are less likely than peers to attend well visits. Medical organizations recommend improving care through staff education, visual cues, and routine inquiry of sexual orientation and gender identity (SO/GI) and pronouns. It is unknown how to do this confidentially in pediatrics. This quality improvement (QI) project aimed to confidentially collect and document SO/GI and pronouns early in at least 90% of teen acute care visits.

METHODS
A diverse, representative QI team in a resident primary care clinic conducted a series of staff and clinician trainings to improve knowledge, then displayed welcoming signage and offered staff pronoun and rainbow pins. Multiple Plan-Do-Study-Act cycles developed methods of routine and private collection of SO/GI and pronouns. Outcome measures included proportion of teen acute visits with such documentation collected via weekly chart reviews. Process measures included staff/clinician preparedness, assessed by surveys.

RESULTS
SO/GI and pronouns were documented in 0% of teen acute visits at baseline, 70% after 6 months, and 90% during the 20-week sustainment measurement phase. The proportion of staff and clinicians who felt prepared to provide care for LGB and transgender patients increased (53% to 68% for LGB, P = .07; and 30% to 57% for transgender, P = .002).

CONCLUSIONS
QI methods can create protocols for confidential, sustainable SO/GI and pronoun collection from teens early in acute visits. This allows clinicians and staff to address patients appropriately and for clinicians to better meet their needs.
Computational fluid dynamics performance evaluation of grooved fins for surfboards
Authors: Elshahomi Alhoush , Kosasih Buyung , Barnsley Grant , Beirne Stephen , Forsyth James , Steele Julie R. , in het Panhuis Marc 
Published: July 2022

AbstractIn this paper, we used computational fluid dynamics simulation (ANSYS CFX) to compare the performance of surfboard fins with grooves (and a bumpy-leading edge) to conventional surfboard fins. The simulations predicted the performance of each type of fins in terms of hydrodynamic forces and their behavior for angles of attack up to 45 degrees. Our results indicated that the pressure contours around fins with grooves (and bumpy-leading edge) were lower compared to pressure contours around conventional fins. The grooved fins exhibited a 13 ± 1% reduction in drag (coupled with a much smaller reduction in lift) at the stall angle, contributing to an overall 11 ± 1% improvement in the lift-to-drag ratio compared to conventional fins.
Graphical abstract
Immunochemotherapy of refractory classical Hodgkin's lymphoma with high-dose consolidation and autologous hematopoietic stem cell transplantation complicated by a new coronavirus infection
Authors: Khayrullina L. S. , Vernyuk M. A. , Chervontseva A. M. , Cherkashina I. V. , Gushchina E. E. , Fedenko A. A. 
Published: July 2022

Classical Hodgkin's lymphoma is one of the most treatable lymphoproliferative diseases with current chemotherapy regimens. The 5-year overall survival rate among patients after initial chemotherapy reaches 95 %, however, despite the significant success achieved, the problem of refractoriness/relapse remains very relevant. A standard approach to the treatment of refractory/recurrent Hodgkin's lymphoma among young patients with preserved general status and chemoresponsive to salvage therapy tumor is high-dose consolidation chemotherapy followed by transplantation of autologous hematopoietic stem cells. The intensification of chemotherapy regimens is highly difficult task for a doctor during the COVID-19 pandemic, which requires careful assessment of a risk-benefit ratio.In current conditions, new targeted and immune drugs are used to overcome resistance and reduce toxicity among pretreated patients, which allows not only to improve the results of a treatment, but also to preserve the high quality of life among patients with extremely unfavorable prognosis.We show our experience of using a checkpoint inhibitor in combination with a dose-intensive regimen of DHAP (dexamethasone, cytarabine, cisplatin) in the treatment of a refractory classical Hodgkin's lymphoma followed by high-dose consolidation chemotherapy and allogeneic hematopoietic stem cells transplantation, among patients complicated with a new coronavirus infection in the post-transplant period.
Hodgkin lymphoma in patient with primary immunodeficiency: clinical features and treatment approaches
Authors: Utesheva K. I. , Belyaeva E. S. , Valiev T. T. , Odzharova A. A. 
Published: July 2022

Primary immunodeficiencies (PID) are genetically determined irreversible disorders of structure and/or functions of the immune system's cellular and humoral components, accompanied by frequent infectious diseases and contributing to the development of malignant neoplasms. Lymphomas are the most frequent oncological disease in PID patients: non-Hodgkin's lymphomas occur in 60 % of malignant neoplasms cases, Hodgkin lymphoma - in 20 %, leukemias - in 10 %, solid tumors - in 10 %. The risk of malignant lymphoproliferative diseases in PID patients amounts to 4-25 %, with the overall incidence of cancer 100-200 times higher than in immunocompetent population. Results of malignant neoplasms treatment in children with PID remain unsatisfactory due to the high rate of relapsed, refractory disease and anticancer therapy complications.This paper presents a clinical case of Hodgkin lymphoma with atypical localization in a female PID patient. peculiarities of this case are eye socket soft tissue involvement, slow response to therapy, and a high rate of infectious complications.
THRIVE: a different approach in microlaryngeal surgeries
Authors: Mittimanj Kavya , Jabanathan Malathi , Chandrashekhar Shishir , Tandon Shantanu 
Published: July 2022

<p>Microlaryngeal surgeries (MLS) are typically performed under general anaesthesia either by employing a microlaryngeal tube or without endotracheal intubation using high frequency jet ventilation. Recently, trans-nasal humidified rapid insufflation ventilatory exchange (THRIVE) without ET tube can be used. It has no compromised view/ access as in MLS tube and no barotrauma/movement of vocal cords/ tumour implantation as in jet ventilation. We aimed to assess the feasibility and safety of tubeless MLS using THRIVE. From December 2019 to December 2020, all the patients undergoing tubeless MLS were included. Anaesthesia was conducted with target controlled propofol infusion and muscle relaxation with THRIVE oxygen support. Perioperative data was collected and analysed. A total of 21 patients underwent MLS using THRIVE as the sole method of ventilation. Mean age was 52.6 (±13.77) years, and mean body mass index (BMI) was 25.63 (±4.91) kg/m<sup>2</sup>. The surgical indications were vocal cord tumor/ biopsy and vocal polyp/cyst excision. Mean apnoea time was 27 min. At the end of surgery, mean end tidal CO<sub>2</sub> was 66 mmHg. Surgeon’s satisfaction about the operating field was recorded and he rated it as either excellent (70%) or good (30%). In carefully selected patients, a combination of THRIVE and TIVA offers a good alternative to conventional anaesthesia with tubes. Our study demonstrated a considerable safe apnoea time with an acceptable CO<sub>2</sub> build up. Surgeon acceptance of the technique was extremely promising and the operating conditions were highly rated by them.</p>
Comparision of ropivacaine 0.2% with or without clonidine in epidural labor analgesia: A randomised controlled study
Authors: Karthik V J , Kanchanamala B , Keerthana N , Kokila C 
Published: July 2022

Epidural labour analgesia is considered as the gold standard of pain relief for paturients inspite of the hesitancy that is prevalent in our country in providing pain-free labour. There are several other pharmacological and non pharmacological methods available for providing labour analgesia. Local anaesthetic is an indispensable drug for administering epidural labour analgesia Ropivacaine is the most widely used local anaesthetic for labour analgesia because of its safety profile proven by various studies.It is less potent and onset of action is slightly prolonged when compared to bupivacaine or levobupivacaine. Use of adjuvants along with local anaesthetic reduces the total dose of local anaesthetic that is required for providing effective labour analgesia. Clonidine is a centrally acting partial alpha 2 adrenergic agonist that reduces the anaesthetic and analgesic requirement of local anaesthetic. This study is aimed to study the effect of ropivacaine with clonidine as an adjuvant for labour analgesia.To compare the time of onset of analgesia, total dose of local anaesthetic required, total duration of analgesia and neonatal outcome between the two groups, Group I with ropivacaine and Group II ropivacaine with clonidine.: A prospective randomised controlled study was conducted in a government peripheral medical College after getting ethical committee clearance 100 patrurients randomised into two groups, Group I received 2% ropivacaine and Group II received 2% ropivacaine with 40 micrograms of clonidine.: The results were analysed with SPSSVersion 13 using student t - test and chi square test The mean age was 23.4 ±1.7 years. The mean onset time of Group A and Group B were 12.9±1.3 minutes and 17.7±1.3 minutes with p&#60;0.001 which was significant. Total mean dose of Ropivacaine for both groups were 44.0±8.8 and 54.0±8.9 respectively with P &#60;0.05. Neonatal outcome as measured using APGAR score were 8.5±0.5 and 8.4±0.5 being statistically insignificant.Addition of 40 micrograms of clonidine with Ropivacaine epidurally resulted in rapid onset of analgesia with required dose of Ropivacaine. Use of Clonidine as adjuvant didn't produce any undesirable motor blockade or neonatal depression.