bluuebunny/crossref_metadata_2025_split huggingface dataset:
Expert pianists make specific exaggerations for teaching
Authors: Tominaga Atsuko , Knoblich Günther , Sebanz Natalie 
Published: December 2022

AbstractExperts modulate their performance of actions for teaching purposes, performing slower and exaggerated movements when demonstrating novel actions to novices. The present study asked whether such modulations also occur during teaching performance of a music instrument, where subtle movement modulations are crucial for achieving artistic expression. While exaggerating performances of goal-directed actions outside of artistic contexts may be straightforward, it is an open question whether and how exaggeration for the purpose of teaching operates for actions that are expressive even when performed outside of a teaching context. Pianists were asked to demonstrate to students the techniques required for implementing notated expressions, compared to performing the piece without didactic intentions. Expressions in the piece concerned either articulation (i.e., legato and staccato) or dynamics (i.e., forte and piano). The pianists played either with the goal to perform the piece to an audience or with the goal to teach the respective techniques to novices. When intending to teach articulation, skilled pianists produced more exaggerated staccato. When intending to teach dynamics, they created a larger contrast between forte and piano. We found consistent results across a simple musical scale (Experiment 1) and a more naturalistic piece of music (Experiment 2). These findings show that teaching-specific action modulations generalise to expressive actions and suggest that action modulations serve to highlight the most relevant aspects of the actions to be learnt.
Hypoxia-associated prognostic markers and competing endogenous RNA coexpression networks in lung adenocarcinoma
Authors: Xiong Lecai , He Xueyu , Wang Le , Dai Peng , Zhao Jinping , Zhou Xuefeng , Tang Hexiao 
Published: December 2022

AbstractLung adenocarcinoma (LUAD) is the most common form of non-small cell lung cancer (NSCLC). Hypoxia has been found in 50–60% of locally advanced solid tumors and is associated with poor prognosis in various tumors, including NSCLC. This study focused on hypoxia-associated molecular hallmarks in LUAD. Fifteen hypoxia-related genes were selected to define the hypoxia status of LUAD by ConsensusClusterPlus based on data from The Cancer Genome Atlas (TCGA). Then, we investigated the immune status under different hypoxia statuses. Subsequently, we constructed prognostic models based on hypoxia-related differentially expressed genes (DEGs), identified hypoxia-related microRNAs, lncRNAs and mRNAs, and built a network based on the competing endogenous RNA (ceRNA) theory. Two clusters (Cluster 1 and Cluster 2) were identified with different hypoxia statuses. Cluster 1 was defined as the hypoxia subgroup, in which all 15 hypoxia-associated genes were upregulated. The infiltration of CD4+ T cells and Tfh cells was lower, while the infiltration of regulatory T (Treg) cells, the expression of PD-1/PD-L1 and TMB scores were higher in Cluster 1, indicating an immunosuppressive status. Based on the DEGs, a risk signature containing 7 genes was established. Furthermore, three differentially expressed microRNAs (hsa-miR-9, hsa-miR-31, hsa-miR-196b) associated with prognosis under different hypoxia clusters and their related mRNAs and lncRNAs were identified, and a ceRNA network was built. This study showed that hypoxia was associated with poor prognosis in LUAD and explored the potential mechanism from the perspective of the gene signature and ceRNA theory.
Resting state functional connectivity as a marker of internalizing disorder onset in high-risk youth
Authors: Pawlak McKinley , Bray Signe , Kopala-Sibley Daniel C. 
Published: December 2022

AbstractWhile research has linked alterations in functional connectivity of the default mode (DMN), cognitive control (CCN), and salience networks (SN) to depression and anxiety, little research has examined whether these alterations may be premorbid vulnerabilities. This study examined resting state functional connectivity (RSFC) of the CCN, DMN, and SN as markers of risk for developing an onset of a depressive or anxiety disorder in adolescents at high familial risk for these disorders. At baseline, 135 participants aged 11–17 completed resting-state functional magnetic resonance imaging, measures of internalizing symptoms, and diagnostic interviews to assess history of depressive and anxiety disorders. Diagnostic assessments were completed again at 9- or 18-month follow-up for 112 participants. At baseline, increased CCN connectivity to areas of the visual network, and decreased connectivity between the left SN and the precentral gyrus, predicted an increased likelihood of a new onset at follow-up. Increased connectivity between the right SN and postcentral gyrus at baseline predicted first episode onsets at follow-up. Altered connectivity between these regions may represent a risk factor for developing a clinically significant onset of an internalizing disorder. Results may have implications for understanding the neural bases of internalizing disorders for early identification and prevention efforts.
Distribution of controlled unitary quantum gates towards factoring large numbers on today’s small-register devices
Authors: Tănăsescu Andrei , Constantinescu David , Popescu Pantelimon George 
Published: December 2022

AbstractFactoring a 2048-bit number using Shor’s algorithm, when accounting for error correction, reportedly requires 400,000 qubits. However, it is well known that there is yet much time before we will have this many qubits in the same local system. This is why we propose a protocol for distributed quantum computation applicable to small register devices, specifically for the distribution of controlled unitary gates, the key element in the construction of every quantum computation algorithm. We leverage quantum sharing of partial results to obtain a parallel processing scheme, allowing for the first time the quantum distribution of very large gates with thousands of inputs using only small register devices with tens of qubits. In this way, we improve all previous controlled unitary gate distribution approaches, obtaining surprising results. The impact is quantified for recent milestone hardware realizations of quantum processors.
Dual-energy CT iodine map in predicting the efficacy of neoadjuvant chemotherapy for hypopharyngeal carcinoma: a preliminary study
Authors: Wei Xianfeng , Cao Rui , Li Han , Long Miaomiao , Sun Peipei , Zheng Yongzhe , Li Li , Yin Jianzhong 
Published: December 2022

AbstractNeoadjuvant chemotherapy has become one of the important means for advanced hypopharyngeal carcinoma. So far, there is no effective index to predict the curative effect. To investigate the value of iodine map of dual-energy computed tomography (CT) in predicting the efficacy of neoadjuvant chemotherapy for hypopharyngeal carcinoma. A total of 54 hypopharyngeal carcinomapatients who underwent two courses of TPF neoadjuvant chemotherapy were recruited in this study. Three cases had a complete response (CR), thirty-six cases had a partial response (PR), eleven cases had stable disease (SD), and four cases had a progressive disease (PD) after the chemotherapy. All patients underwent a dual-source CT scan before chemotherapy and rescanned after chemotherapy. The normalized iodine-related attenuation (NIRA) of the mean of maximum slice and most enhanced region of lesion at arterial and parenchymal phase were measured: NIRAmean-A, NIRAmax-A, NIRAmean-P, and NIRAmax-P, respectively. Correlation analysis was conducted between different metrics of NIRA and the diameter change rate of lesions, and the curative effect was evaluated based on the receiver operating characteristic (ROC) curve. There were a significant correlation between NIRAmean-A, NIRAmax-A, NIRAmean-P, NIRAmax-P and the change rate of lesion’s maximum diameter (ΔD%) (all P < 0.01). The NIRAmax-A, NIRAmean-P, NIRAmax-P had significant differences between CR, PR, SD, PD groups, but NIRAmean-A did not reach a significant difference. All NIRAmean-A, NIRAmax-A, NIRAmean-P, NIRAmax-P had significant differences between effective (CR + PR) and ineffective (SD + PD) groups. The ROC analysis revealed that NIRAmean-P had the largest AUC and prediction efficacy (AUC = 0.809). Dual-energy CT iodine map could predict the efficacy of neoadjuvant chemotherapy and provides imaging evidence to assist in treatment decisions for hypopharyngeal carcinoma patients.
Floquet engineering of tilted and gapped Dirac bandstructure in 1T$$^\prime$$-MoS$$_2$$
Authors: Iurov Andrii , Zhemchuzhna Liubov , Gumbs Godfrey , Huang Danhong , Tse Wang-Kong , Blaise Kathy , Ejiogu Chinedu 
Published: December 2022

AbstractWe have developed a rigorous theoretical formalism for Floquet engineering, investigating, and subsequently tailoring most crucial electronic properties of 1T$$^\prime$$

′

-MoS$$_2$$

2

by applying an external high-frequency dressing field within the off-resonance regime. It was recently demonstrated that monolayer semiconducting 1T$$^\prime$$

′

-MoS$$_2$$

2

exhibits tunable and gapped spin- and valley-polarized tilted Dirac bands. The electron-photon dressed states depend strongly on the polarization of the applied irradiation and reflect a full complexity of the low-energy Hamiltonian for non-irradiated material. We have calculated and analyzed the properties of the electron dressed states corresponding to linear and circular polarization of a dressing field by focusing on their symmetry, anisotropy, tilting, direct and indirect band gaps. Circularly polarized dressing field is known for transition into a new electronic state with broken time-reversal symmetry and a non-zero Chern number, and therefore, the combination of these topologically non-trivial phases and transitions between them could reveal some truly unique and previously unknown phenomena and applications. We have also computed and discussed the density of states for various types of 1T$$^\prime$$

′

-MoS$$_2$$

2

materials and its modification in the presence of a dressing field.
High-frequency ultrasound in patients with seronegative rheumatoid arthritis
Authors: Wang Junkui , Wang Miao , Qi Qinghua , Wu Zhibin , Wen Jianguo 
Published: December 2022

AbstractThis study aimed to investigate the value of high-frequency ultrasound (HFUS) in differentiation of the seronegative rheumatoid arthritis (SNRA) and osteoarthritis (OA) and in the diagnosis of SNRA. 83 patients diagnosed with SNRA (SNRA group) and 40 diagnosed with OA (OA group) who received HFUS were retrospectively analyzed. The grayscale (GS) scores, power Doppler (PD) scores, and bone erosion (BE)scores were recorded, and added up to calculate the total scores of US variables. The correlations of the total scores of US variables with the 28-joint disease activity score (DAS28), erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) were analyzed. The diagnostic efficacy of the total scores of US variables for SNRA was assessed. In the SNRA group, the detection rate of abnormal US findings in the joints and tendons by GS and PD as well as BE was higher than those in the OA group. There were significant differences between the two groups in GS scores and PD scores of joints and tendons, and BE scores of joints (P < 0.05). In the SNRA group, the total scores of most US variables were positively correlated with CRP, ESR, and DAS28 (P < 0.05), while such correlations were not observed in the OA group (P > 0.05). Among different US variables, the diagnostic value of total PD scores of the joints was the highest for SNRA. HFUS could be used to differentiate SNRA from OA and make a diagnosis of SNRA based on joint and tendon synovial sheath assessment.
Advanced maternal age and severe maternal morbidity in South Korea: a population-based cohort study
Authors: Kim Juyeong , Nam Jin Young , Park Eun-Cheol 
Published: December 2022

AbstractTo investigate the association between maternal age and severe maternal morbidity (SMM) in a Korean population. Data for cases of delivery between 2003 and 2019 were extracted from the Korean National Health Insurance Service-National Delivery Cohort. The main outcome was SMM, which was determined using the Center for Disease Control and Prevention’s algorithm. A generalized estimating equation model with a log link was performed for the relationship between SMM and maternal age adjusted for covariates. SMM occurred in 40,959/2,113,615 (1.9%) of delivery cases. Teenagers and women 35 years and older had an increased risk of SMM in both nulliparous and multiparous cases (ages 15–19: risk ratio (RR) 1.32, 95% confidence interval (CI) 1.15–1.46; ages 35–39: RR 1.24, 95% CI 1.21–1.28; ages 40–44: RR 1.57, 95% CI 1.50–1.64; and ages 45 or older: RR 2.07, 95% CI 1.75–2.44). Women aged 40 years and older had the highest rates of SMM. In singleton births as well as in nulliparous and multiparous cases, teenagers and women aged 35 years and older had a particularly high risk of SMM. Identifying and managing risk factors for SMM in these vulnerable age groups may improve maternal health outcomes.
Cycloidal-spiral sampling for three-modal x-ray CT flyscans with two-dimensional phase sensitivity
Authors: Lioliou G. , Roche i Morgó O. , Marathe S. , Wanelik K. , Cipiccia S. , Olivo A. , Hagen C. K. 
Published: December 2022

AbstractWe present a flyscan compatible acquisition scheme for three-modal X-Ray Computed Tomography (CT) with two-dimensional phase sensitivity. Our approach is demonstrated using a “beam tracking” setup, through which a sample’s attenuation, phase (refraction) and scattering properties can be measured from a single frame, providing three complementary contrast channels. Up to now, such setups required the sample to be stepped at each rotation angle to sample signals at an adequate rate, to prevent resolution losses, anisotropic resolution, and under-sampling artefacts. However, the need for stepping necessitated a step-and-shoot implementation, which is affected by motors’ overheads and increases the total scan time. By contrast, our proposed scheme, by which continuous horizontal and vertical translations of the sample are integrated with its rotation (leading to a “cycloidal-spiral” trajectory), is fully compatible with continuous scanning (flyscans). This leads to greatly reduced scan times while largely preserving image quality and isotropic resolution.
Refining Semantic Similarity of Paraphasias Using a Contextual Language Model
Authors: Salem Alexandra C. , Gale Robert , Casilio Marianne , Fleegle Mikala , Fergadiotis Gerasimos , Bedrick Steven 
Published: December 2022

Purpose:
ParAlg (Paraphasia Algorithms) is a software that automatically categorizes a person with aphasia's naming error (paraphasia) in relation to its intended target on a picture-naming test. These classifications (based on lexicality as well as semantic, phonological, and morphological similarity to the target) are important for characterizing an individual's word-finding deficits or anomia. In this study, we applied a modern language model called BERT (Bidirectional Encoder Representations from Transformers) as a semantic classifier and evaluated its performance against ParAlg's original word2vec model.

Method:
We used a set of 11,999 paraphasias produced during the Philadelphia Naming Test. We trained ParAlg with word2vec or BERT and compared their performance to humans. Finally, we evaluated BERT's performance in terms of word-sense selection and conducted an item-level discrepancy analysis to identify which aspects of semantic similarity are most challenging to classify.

Results:
Compared with word2vec, BERT qualitatively reduced word-sense issues and quantitatively reduced semantic classification errors by almost half. A large percentage of errors were attributable to semantic ambiguity. Of the possible semantic similarity subtypes, responses that were associated with or category coordinates of the intended target were most likely to be misclassified by both models and humans alike.

Conclusions:
BERT outperforms word2vec as a semantic classifier, partially due to its superior handling of polysemy. This work is an important step for further establishing ParAlg as an accurate assessment tool.
Multiscale attention dynamic aware network for fine‐grained visual categorization
Authors: Ou Jichu , Li Wanyi , Huang Jingmin , Huang Xiaojie , Xie Xuan 
Published: December 2022

AbstractFine‐grained visual categorization (FGVC) is a challenging task, facing the issues such as inter‐class similarities, large intra‐class variances, scale variation, and angle variation. To address these issues, the authors propose a novel multiscale attention dynamic aware network (MADA‐Net). The core of network consists of three parallel sub‐networks, which learn features from different scales. Each sub‐network is composed of three serial sub‐modules: (1) A self‐attention module (SAM) locates objects according to relative importance scattered throughout feature map. (2) A multiscale feature extractor (MFE) learns the non‐linear features of objects. (3) A dynamic aware module (DAM) enhances the learning capability of spatial deformation of the network to generate high‐quality feature map. In addition, the authors propose a multiscale adjusted loss (MA‐Loss) to improve the performance of network. Experiments on three prevailing benchmark datasets demonstrate that our method can achieve state‐of‐the‐art performance.
Der Letzte macht das Licht AN – Sterben als Teil des
Lebens
Authors: Schütte-Nütgen Katharina , Becker Gerhild 
Published: December 2022

ZusammenfassungSowohl aufgrund der demografischen Entwicklung in Deutschland, als auch
angesichts des raschen Fortschritts der modernen Hochleistungsmedizin ist die
Forderung nach einem bedarfsdeckenden Ausbau der Palliativmedizin lauter
geworden. Trotz der bedeutsamen Weiterentwicklung dieses Fachgebiets wird die
Palliativmedizin nicht nur in der Öffentlichkeit, sondern auch in vielen
Bereichen der Medizin noch immer ausschließlich mit dem nahenden
Lebensende in Verbindung gebracht und es herrscht die Vorstellung, dass Sterben
und Tod in eigens dafür eingerichteten Bereichen wie der
Palliativstation stattfinden, außerhalb der Gesellschaft und getrennt
von den übrigen medizinischen Versorgungsstrukturen. In dieser
Falldarstellung berichten wir über eine 36-jährige Patientin,
die durch den palliativmedizinischen Dienst betreut wurde. Das Fallbeispiel
spiegelt die vielfältigen Aspekte der palliativmedizinischen Versorgung
wider und zeigt, dass das Sterben aus der Akutmedizin nicht ausgelagert werden
kann und darf. Die Integration und Weiterentwicklung der Palliativmedizin kann
helfen, ein verändertes Bewusstsein zu entwickeln und das Sterben
(wieder) als Teil der Akutmedizin – ja des Lebens –
anzuerkennen. Dies ist nicht nur für die Patienten, sondern auch
innerhalb der ärztlichen und pflegerischen Profession entscheidend.
Chronische muskuloskelettale Schmerzen im Kindes- und Jugendalter
Authors: Schramm Anja , Aigner Anna , Haas Johannes-Peter , Höfel Lea 
Published: December 2022

ZUSAMMENFASSUNGChronische anhaltende oder wiederkehrende Schmerzen am Bewegungsapparat über einen Zeitraum von mindestens 3 Monaten sind bei Kindern und Jugendlichen zunehmend zu beobachten. Der Schmerz kann dabei seine Funktion als Warnsignal verlieren und verselbstständigt sich aufgrund von Veränderungen im Schmerzverarbeitungssystem. Die chronische Schmerzstörung mit somatischen und psychischen Faktoren, die anhaltende somatoforme Schmerzstörung und das komplexe regionale Schmerzsyndrom (CRPS) äußern sich in starken Schmerzen, haben einen negativen Einfluss auf das psychische Befinden und beeinträchtigen die jugendgerechte Lebensführung. In Diagnostik, Edukation und Therapie müssen nun andere Schwerpunkte gelegt werden als bei akuten Schmerzen, welche üblicherweise aufgrund von Verletzungen, entzündlichen Vorgängen oder sonstigen somatischen Ursachen auftreten. Eine multiprofessionelle Zusammenarbeit ist sowohl im ambulanten als auch im stationären Setting wünschenswert und wird am Beispiel der stationären interdisziplinären multimodalen Schmerztherapie (IMST) vorgestellt.
Auf steinigem Weg
Authors: Heeser Alexandra 
Published: December 2022

ZusammenfassungWer viel fragt, kriegt viele Antworten. Das zeigen die Umfragen zur Pflegekammer. Hätte man die Ärzte abstimmen lassen, ob sie eine Ärztekammer wünschen, hätte es in Deutschland vermutlich auch einen ziemlichen Flickenteppich gegeben. Hier ein Überblick.
Lehrende müssen Lernende werden
Authors: Woideck Steffen , Benz Manuel 
Published: December 2022

ZusammenfassungMit dem Startschuss zur neuen Pflegeausbildung, kurz Generalistik, war Schulleitungen wie Lehrenden klar: Das wird eine Mammutaufgabe. Lesen Sie mehr über die ersten Erfahrungen der Caritas Fachschule für Pflegeberufe Sancta Maria in Bühl.
Therapieoptionen zur LDL-C-Senkung zusätzlich zu Statinen
Authors: Weingärtner Oliver , Marx Nikolaus , Klose Gerald , Laufs Ulrich 
Published: December 2022

ZUSAMMENFASSUNGDie aktuellen Leitlinien für Dyslipidämie heben Statine als Eckpfeiler der pharmakologischen Lipidsenkungstherapie hervor. Ezetimib, PCSK9-Antikörper sowie Bempedosäure und Inclisiran sind neu verfügbare Optionen zur weiteren Senkung des LDL-C. Da die moderne Lipidsenkungstherapie durch einen individuellen „Treat-to-Target“-Ansatz gekennzeichnet ist, soll dieser Beitrag zu einem besseren Verständnis des Cholesterinstoffwechsels beitragen, um den rationalen Einsatz früher individualisierter Kombinationstherapien zu unterstützen.
Cerebral Cavernous Malformations Patient Perception Analysis via Social Media
Authors: Gajjar Avi A. , Jain Aditya , Le Anthony Huy-Dinh , Salem Mohamed M. , Jankowitz Brian T. , Burkhardt Jan-Karl 
Published: December 2022

Abstract
Background The rise of social media has allowed for individuals and patients to connect with each other and influence patient behavior. This study aimed to improve our understanding of the patients' experience with cerebral cavernous malformations (CCM) via social media.
Methods Instagram and Twitter were searched using terms of (“cavernoma,” “cavernous malformations,” “cavernous angioma,” or “cav mal”). Public Instagram posts tagged with “#cavernoma” and “@cavernoma” identified 327 posts that directly included a patient's own experience. Twitter posts that included “#cavernoma” and “@cavernoma” were searched, yielding 75 after eliminating those that did not pertain to the patient's own experience. The posts and tweets were coded for relevant themes related to their experience with the disease.
Results Overall, more patients are using Instagram (n  =  327) over Twitter (n  =  84) to share their personal experience with CCM with a trend for male patients to use Twitter more compared to females with a female predominance in Instagram. A total of 277 of 327 (84.7%) Instagram posts and 67 of 84 (89.3%) Twitter posts were made after the patient's surgery. The most common theme on Instagram was focused on the postoperative rehabilitation process and mobility support (52.0 and 24.5%, respectively). Other common themes present on Twitter and Instagram were recounting symptoms and complications and life satisfaction (26.0 and 24.2%, respectively). Cavernoma patients prior to surgery were more likely to discuss on Instagram their symptoms (p  =  0.001), fear of bleeding (p  <  0.001), and mental health (p  =  0.014). Postoperatively, cavernoma patients were more likely to discuss disability than they were preoperatively (p  =  0.001).
Conclusion Social media platforms offer a communication tool for patients with CCM patients to share their experience with other patients and the general public and portrays their personal experience with CCM. These platforms allow for physicians to better understand the patient experience following cavernoma surgery.