bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pseudomembranous Colitis in a Coronavirus Disease 19 positive patient : not a simple issue
Authors: Thayer Maissa Ben , Khanchel Fatma , Helal Imen , Zaafouri Haithem , Hedhli Raoueh , Brahim Ehsen Ben , Jouini Raja , Chadli-Debbiche Aschraf 
Published: September 2022

Abstract
Since its emergence, Coronavirus Disease (Covid-19) rapidly spread worldwide and was responsible for a global pandemic. Although it was initially considered a respiratory disease, recent studies have evidenced that Covid-19 had serious systemic adverse effects involving major organs, including those of the digestive system. Histological lesions associated with these manifestations have rarely been reported. We, herein, present a singular case of pseudomembranous colitis (PMC), proven histologically, in a 73-year-old Covid-19 positive female patient. We aim to study the clinico-pathological characteristics of this association. A 73-year-old Covid positive patient was intubated and put on intravenous antibiotherapy after the deterioration of her respiratory function. Ten days after admission, the patient presented abdominal distension and melena. An abdominal tomography scan showed a left mesenteric infarction related to a thrombosis at the origin of the left mesenteric artery. A left hemicolectomy was performed in emergency. Macroscopic examination of the hemicolectomy specimen showed an edematous colonic mucosa, with multiple ulcerations covered by a whitish necrotic coating reminiscent of false membranes. Histological examination confirmed the diagnosis of PMC. The patient presented a septic shock and died six days after the operation. The PMC could have resulted from the use of antibiotics. However, the direct involvement of Covid-19 in the occurrence of this PMC cannot be excluded. Further studies are needed to evaluate the direct correlation between Covid-19 and PMC.
Implications of Strategic Position Choices by Candidates
Authors: Robinette Robbie 
Published: September 2022

Abstract
I examine the implications of strategic position choices by candidates under two different voting rules: Instant Runoff and Condorcet-Minimax. A neural net forecasts the chances of winning at different ideologies and candidates alter their ideology to maximize their expected utility. This results in different candidate behavior and outcomes than in the non-strategic scenario. Further, the maximal utility strategy differs significantly between the two voting rules being examined. I propose a refinement to the social utility efficiency metric to account for the different utility of the candidate’s chosen positions and use this metric to contrast the outcomes. Finally, this divergence in strategy calls into question the practice of using data (ballots, or survey data) gathered under one voting rule to analyze a different voting rule.
Frequency of risk factors of coronary heart diseases in patients with acute coronary syndrome and its comparison in male and female
Authors: Mazhar Naqash , Khan Usman Hassan , Mand Bakhat , Rehman Abdur , Mubeen Maryam , Malik Mohammad Hamza Bin Abdul , Hussain Syed Anas 
Published: September 2022

Abstract
Objectives
The main objective of the study is to find the frequency of risk factors of coronary heart diseases in patients with acute coronary syndrome and its comparison in male and female.
Material and methods
This cross-sectional study was conducted in Services Institute of medical sciences during June 2021 to June 2022. The data was collected with the permission of ethical committee of hospital.
Results
The data was collected from 100 male and female patients. The mean age was 45.67 ± 2.89 years for males and 49.89 ± 5.67 years for females. The major risk factors for diseases is hypertension, hyperlipidemia, smoking and diabetes. According to data all the patients must contain one of these major risk factors and many of the patients had more then one risk factors.
Conclusion
It is concluded that all the patients must have one of the major risk factors as a cause of diseases. Women with acute coronary syndrome, as compared to men, have more prevalence of diabetes and hypertension, and less prevalence of smoking.
[18F]Sodium-fluoride PET/MRI monitoring of hormonal therapy response in breast cancer bone metastases – Proof of concept
Authors: Zia Maira , Lundström Elin , Mårtensson Johanna , Lubberink Mark , Schiza Aglaia , Sundin Anders 
Published: September 2022

Abstract

RECIST 1.1 tumour size measurements on CT/MRI are the mainstay of cancer therapy monitoring. However, bone metastases are consistently difficult to evaluate for hormonal therapy response often escaping CT detection. This study aimed to assess dynamic and static [18F]sodium fluoride-([18F]NaF)-PET/MRI by combining SUV and net influx rate (Ki) from PET with the apparent diffusion coefficient (ADC), proton density fat fraction (PDFF) and effective transverse relaxation rate (R2*) from MRI for monitoring hormonal therapy effect on bone metastases. In this prospective study, three breast cancer patients underwent a 60-minute dynamic whole-body [18F]NaF-PET/MRI before and after hormonal therapy. In PET images, pelvic and spine metastases (approx. n = 10/patient) with high/intermediate uptake were delineated by applying an adaptive threshold algorithm to provide SUVmeanand SUVmax. Pharmacokinetic modeling was performed and Kiwas calculated using a two-tissue reversible model. VOI measurements of ADC, PDFF and R2*utilized the OLEA medical software. The changes between baseline and follow-up data were calculated, statistically analysed and utilized linear regression. [18F]NaF-PET/MRI provided a powerful method for monitoring hormonal therapy response in breast cancer bone metastases as reflected by decreases in SUV and Ki. MRI parameters showed changes consistent with therapy response, although only R2*reached statistical significance.
Evaluation of Synergy Ability and Reconstruction of Synergy Organization for Marine Disaster Monitoring and Early Warning in Coastal Cities, China
Authors: huang xing 
Published: September 2022

Abstract
In order to improve the synergy level of marine disaster monitoring and early warning in coastal cities, an evaluation index system of 21 factors with 5 dimensions was constructed based on the synergy theory. The weights of all levels of indicators were determined by coefficient of variation method, and 24 representative coastal cities in China were evaluated by multi-level grey relational method. The evaluation results show that: the level of synergy in each dimension of 24 coastal cities is uneven, and the distribution level is not high. The level of synergy of marine disaster monitoring and early warning in coastal cities is positively correlated with the level of economic development. The level of synergy of monitoring and early warning of marine disasters in 24 coastal cities is not high, which is generally distributed in medium and low levels. Furthermore, according to the evaluation results and the current situation of marine disaster monitoring and early warning in coastal cities, a network organization structure is proposed to enhance the synergy ability of coastal city monitoring and early warning, so as to provide practical basis for the construction of China's coastal cities in the global marine disaster monitoring and early warning synergy.
Identification of 5F-Cumyl-PINACA, a Synthetic Cannabinoid, in the
Herbal Material Used for Recreational Purposes in the Province of Trieste:
Public Health Implications
Authors: Peruch Michela , Addobbati Riccardo , Padovano Martina , Scopetti Matteo , Concato Monica , Radaelli Davide , D’Errico Stefano 
Published: September 2022

Background:
In recent years, the phenomenon of the production and trade of synthetic cannabinoids has grown, becoming a public health issue worldwide. The recent accesses - to the ED of the hospital of Trieste - of people who complained episodes of hallucinations, sensation of poisoning, tachycardia, and air hunger following the inhalation of "Che Sballo platinum", have highlighted the need to perform further analysis on the contents of the packet sold as an air freshener, produced in Koper (Slovenia).

Objective:
This paper wants to be an alert about the possible consequences on health due to the spreading of “Che Sballo platinum” in the province of Trieste.

Methods:
The contents of the package was analyzed by a multi-target screening method of MRM-IDA-EPI experiment. The result was then confirmed, and quantification was achieved via LC-ESI-MS/MS analysis in MRM mode using QTrap 6500 + Sinergy hydro column 100 x 2 mm 1.9um transitions MRM1 368.3  250.0; MRM2 368.3  233.0.

Results:
The initial screening tested negative for THC and showed positive results for 5F-Cumyl-PINACA. Quantitation result reported dose by package of 8.5 mg of the compound. Formal notification was sent to the Italian Health Authorities (notification no 2021110205).

Conclusion:
Consumption of 5F-Cumyl-PINACA results in much more potent effects than marijuana. Lack of information about the actual concentration of the substance on the packaging does not allow drug users to have an adequate dosage, with possible toxic consequences on health. Further investigations must be done to discover the true extent of the phenomenon.
Understanding the Role of NRF2 Signalling in Cancer
Authors: Basalingappa Kanthesh M. , Singh Pooja G. , Gopenath T.S. , MN Ramesh Bharadwaj , Ilangovan R. 
Published: September 2022

Abstract:
Nuclear factor erythroid 2 (NFE 2) - related factor 2 (NFE2L2 or NRF2) is one of the transcription
factors predominantly related to the expression of antioxidant genes. NRF2 plays a pivotal
role in controlling redox potential in several tumor characteristics, including cancer cell metabolism,
stem-cell-like characteristics, tumor aggressiveness, invasion, and metastasis. Further, it was recently
discovered that the noncanonical pathway of NRF2 activation was involved in carcinogenesis. Cancerrelated
changes (e.g., metabolic flexibility) that support cancer progression were found to be redox and
NRF2 dependent. The pro or antineoplastic effects of NRF2 are essentially based on the specific molecular
characteristics of the type of cancer. Therefore, systematic investigation of NRF2 signaling is
necessary to clarify its role in cancer etiology. Understanding the role of NRF2 in triggering gene expressions
in different types of cancer is quite challenging, which might be useful to target those genes
for better clinical outcomes. To decipher the role of NRF2 in tumor formation and progression, largescale
genomic and transcriptomic studies are required to correlate the clinical outcomes with the activity
of the NRF2 expression system. This review attempts to give insights into the understanding of
the role of NRF2 in cancer.
Investigating Association Level of CXCL12 with its SDF-1α 3′A Genetic
Variant and CXCL10 with its 1443 Promoter Polymorphism in Type-1
Diabetes
Authors: Derakhshan Shokoofeh , Hassanshahi Gholamhossein , Karimabad Mojgan Noroozi , Torabizadeh Seyedeh Atekeh 
Published: September 2022

Background:
Type-1 diabetes mellitus (T1DM) has been described as an autoimmune and heterogeneous disorder. In the present study, we aimed to examine whether there exists an association between serum CXCL10 (IP-10) level and its promoter polymorphism at position-1443 as an angiostasis alongside CXCL12 and its known SDF-1 3′ A genetic variant as an angiogenesis chemokine in T1DM patients.

Methods:
Blood specimens were collected from 209 unrelated T1DM patients, as well as from 189 healthy subjects. The DNA samples were extracted from the subjects and analyzed for CXCL10 and CXCL12 polymorphisms by employing PCR-RLFP. The serum concentrations of CXCL10 and CXCL12 were also analyzed with ELISA.

Results:
Following expert opinion and data analysis, we found significant differences between A/A, A/G, and G/G genotypes with A and G alleles of polymorphisms at position +801 (SDF-1α3′A) in CXCL12. We did not observe an association between CXCL10/-1443 promoter polymorphism and T1DM. In our assessment of promoter polymorphism, both T1DM patients and controls had GG genotype in CXCL10/-1443. When patients were compared with controls, both serum CXCL10 and CXCL12 levels are increased in type 1 diabetes with complications. Levels were not increased in patients without complications.

Conclusion:
Both CXCL10 and CXCL12 play fundamental roles in T1DM pathogenesis. Only the CXCL12 3′A (SDF-1α3′A) polymorphism is possibly necessary for the pathogenesis of T1DM, while the CXCL10-1443 promoter polymorphism is not.
Molecular Insights on Bioactive Compounds against Covid-19: A Network
Pharmacological and Computational Study
Authors: Thangavel Saraswathi Nambiappan , Jeevanandam Jayanth , Paramasivam Esackimuthu , Palanisamy Anbumathi , Raghavendran Srikanth 
Published: September 2022

Background:
Network pharmacology based identification of phytochemicals in the form of
cocktails against off-targets can play a significant role in the inhibition of SARS_CoV2 viral entry and
its propagation. This study includes network pharmacology, virtual screening, docking and molecular
dynamics to investigate the distinct antiviral mechanisms of effective phytochemicals against
SARS_CoV2.

Methods:
SARS_CoV2 human-protein interaction network was explored from the BioGRID database
and analysed using Cytoscape. Further analysis was performed to explore biological function, proteinphytochemical/
drugs network and up-down regulation of pathological host target proteins. This led to
understand the antiviral mechanism of phytochemicals against SARS_CoV2. The network was explored
through g: Profiler, EnrichR, CTD, SwissTarget, STITCH, DrugBank, BindingDB, STRING and SuperPred.
Virtual screening of phytochemicals against potential antiviral targets such as M-Pro, NSP1,
Receptor binding domain, RNA binding domain, and ACE2 discloses the effective interaction between
them. Further, the binding energy calculations through simulation of the docked complex explain the
efficiency and stability of the interactions.

Results:
The network analysis identified quercetin, genistein, luteolin, eugenol, berberine, isorhamnetin
and cinnamaldehyde to be interacting with host proteins ACE2, DPP4, COMT, TUBGCP3, CENPF,
BRD2 and HMOX1 which are involved in antiviral mechanisms such as viral entry, viral replication,
host immune response, and antioxidant activity, thus indicating that herbal cocktails can effectively
tackle the viral hijacking of the crucial biological functions of a human host. Further exploration through
virtual screening, docking and molecular dynamics recognizes the effective interaction of phytochemicals
such as punicalagin, scutellarin, and solamargine with their respective potential targets.

Conclusion:
This work illustrates a probable strategy for the identification of phytochemical-based
cocktails and off-targets which are effective against SARS_CoV 2.
Trajectory Tracking Control for Small Electric Sweeper Based on the
Hybrid Control Method
Authors: Li Xiaowei , Li Qing , Zhang Junhui 
Published: September 2022

Background:
Trajectory tracking, one of the critical automatic driving technologies, is
significant for the operation of small electric sweepers working in complex road environments,
such as campuses and closed parks.

Methods:
This paper investigates a trajectory tracking control system for small self-driving electric
sweepers on roads with different operating speed requirements. A hybrid control method combining
sliding mode control and model predictive control is proposed, with sliding mode control operating
under low-speed (<2 m/s) conditions, and model predictive control operating under high-speed (>2
m/s) conditions. An improved sliding mode controller based on the kinematic model is designed to
reduce chattering, and a model predictive controller based on the dynamics model is constructed.

Result:
Finally, the performance of the hybrid control method is verified using the MATLAB/
Simulink platform.

Conclusion:
The simulation results prove the effectiveness of the hybrid control method and the
good tracking performance of the electric sweeper at different driving speeds.
Addiction Symptom Network of Young Internet Users: Network Analysis
Authors: Lu Jianxia , Zhang Qinhan , Zhong Na , Chen Jin , Zhai Yujia , Guo Lei , Lu Chunlei , Chen Tianzhen , Jiang Zhongli , Zheng Hui 
Published: September 2022

Background
An increasing number of people are becoming addicted to the internet as a result of overuse. The Internet Addiction Test (IAT) is a popular tool for evaluating internet use behaviors. The interaction between different symptoms and the relationship between IAT and clinical diagnostic criteria are not well understood.

Objective
This study aimed to explore the core symptoms of internet addiction (IA) and the correlation between different symptoms of the IA symptom network. Network analysis was also conducted to explore the association between the IAT scale and the Diagnostic and Statistical Manual of Mental Disorders–5th edition (DSM-5) criteria for IA.

Methods
We recruited 4480 internet users (aged 14-24 years), and they completed the IAT. The final analysis included 63.50% (2845/4480) of the participants after screening the submitted questionnaires. Participants were classified into IA group and non-IA (NIA) group. By using partial correlation with Lasso regularization networks, we identified the core symptoms of IA in each group and compared the group differences in network properties (strength, closeness, and betweenness). Then, we analyzed the symptom networks of the DSM-5 diagnostic criteria and IAT scale for IA.

Results
A total of 12.47% (355/2845) of the patients were in the IA group and 87.52% (2490/2845) of the patients were in the NIA group, and both groups were evaluated for the following nodes: IAT_06 (school work suffers; strength=0.511), IAT_08 (job performance suffers; strength=0.531), IAT_15 (fantasize about being on the web; strength=0.474), IAT_17 (fail to stop being on the web; strength=0.526), and IAT_12 (fear about boredom if offline; strength=0.502). The IA groups had a stronger edge between IAT_09 (defensive or secretive about being on the web) and IAT_18 (hidden web time) than the NIA groups. The items in DSM-5 had a strong association with IAT_12 (weight=−0.066), IAT_15 (weight=−0.081), IAT_17 (weight=−0.106), IAT_09 (weight=−0.198), and IAT_18 (weight=−0.052).

Conclusions
The internet use symptom network of the IA group is significantly different from that of the NIA group. Nodes IAT_06 (school work affected) and IAT_08 (work performance affected) are the resulting symptoms affected by other symptoms, whereas nodes IAT_12 (fear about boredom if offline), IAT_17 (inability to stop being on the web), and IAT_15 (fantasize about being on the web) are key symptoms that activate other symptoms of IA and are strongly linked to the inability to control the intention to play games in the DSM-5.
Dampak perubahan tutupan lahan terhadap suhu permukaan di Perkotaan Temanggung: Menuju realisasi program infrastruktur hijau
Authors: Sumaryana Hendra , Buchori Imam , Sejati Anang Wahyu 
Published: September 2022

Abstrak Urbanisasi membawa pengaruh yang besar pada lingkungan perkotaan, salah satunya adalah perubahan guna lahan yang memengaruhi perubahan iklim seperti kenaikan suhu permukaan di perkotaan atau Surface Urban Heat Islands (SUHI). Penelitian di Perkotaan Temanggung untuk melihat dampak fenomena SUHI, menemukenali ancaman dan respon yang tepat dalam penanganannya. Analisis spasial dengan SIG yang dilakukan antara lain klasifikasi, overlay, dan digital image processing. Hasil penelitian menunjukan Infrastruktur Hijau (IH) yang sudah ada belum dapat menurunkan SUHI secara optimal. Didapat kawasan terbangun bertambah seluas 98,29 atau naik 22% di wilayah penelitian pada priode 2013 – 2020, sehingga mengakibatkan kenaikan suhu permukaan. Wilayah yang mengalami kenaikan suhu permukaan diatas 30 °C bertambah 84,96 ha atau naik 268 % dibandingkan pada tahun 2013. .Hal ini mengindikasikan bahwa pengembangan Infrastruktur Hijau (IH) masih harus terus dilakukan. Penelitian ini membuktikan bahwa untuk menjamin kota yang berkelanjutan, perencanaan IH harus menjadi program prioritas. Abstract Urbanization has a big influence on the urban environment, one of which is land use changes that affect climate change such as the increase in Surface Urban Heat Islands (SUHI). Based on the impact and the urgency of this phenomenon, this study aims to identify threats and appropriate responses in handling them. Spatial analysis in GIS carried out include classification, Overlay, and Digital Image Processing. The results show that the existing Green Infrastructure (IH) has not been able to reduce SUHI. It was found that the built area increased by 98.29 or increased by 22% in the research area in the 2013 - 2020 period, resulting in an increase in surface temperature. Areas experiencing a high increase in surface temperature above 30 ° C increased by 84.96 ha or an increase of 268% compared to 2013.. This indicates that the development of Green Infrastructure (GI) still has to be carried out. This research proves that to ensure a sustainable city, GI planning must be a priority program.
Beta Cell Function, Hepatic Insulin Clearance, and Insulin Sensitivity in South Asian and Nordic Women after Gestational Diabetes Mellitus
Authors: Sharma Archana , Lee-Ødegård Sindre , Qvigstad Elisabeth , Sommer Christine , Sattar Naveed , Gill Jason M.R. , Gulseth Hanne L. , Sollid Stina T. , Nermoen Ingrid , Birkeland Kåre I. 
Published: September 2022

<p>South Asians have higher risk of type 2 diabetes after gestational diabetes mellitus (GDM) than Nordic women; however the mechanisms behind this difference remain unclear. We investigated insulin sensitivity, beta cell function, and hepatic insulin clearance, in 179 South Asian and 108 Nordic women ~17 months after GDM (mean age 35.3 years and BMI 29.1 kg/m2), via an oral glucose tolerance test using deconvolution of C-peptide kinetics. 31% of South Asian and 53% of Nordic participants were normoglycemic at the time of measurement. <strong>South Asian women</strong> had higher area under the curve (AUC) for glucose, pre-hepatic insulin, peripheral insulin, and lower levels of insulin sensitivity, disposition index, and fasting hepatic insulin clearance compared with Nordic women. In the group with prediabetes or diabetes, South Asian women displayed similar AUC for glucose and pre-hepatic insulin, but higher AUC for peripheral insulin, and lower levels of disposition index, and fasting hepatic insulin clearance compared with Nordic women. The waist-to-height ratio mediated ~25-40% of the ethnic differences in insulin sensitivity in normoglycemic women. Overall, our novel data showed that normoglycemic South Asian women after GDM displayed lower insulin secretion for a given insulin resistance, and lower hepatic insulin clearance compared with Nordic women. South Asian women are at high risk of developing type 2 diabetes after GDM, and preventive efforts should be prioritized. </p>