bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association of urinary bisphenol A concentrations with in vitro fertilisation outcomes: a systematic review and meta-analysis protocol
Authors: Cao Xian-Ling , Xu Nai-Xin , Zhou Xuan-You , Xu Chen-Ming 
Published: November 2022

IntroductionBisphenol A (BPA) is a common environmental endocrine disruptor. BPA has been reported to be associated with female infertility, which may not only affect natural pregnancy and natural fertility but also affect the outcomes of in vitro fertilisation (IVF). BPA exposure may help to partly explain the unsatisfactory IVF outcomes, but the relationship between the concentrations of BPA in urine and IVF outcomes remains controversial. Therefore, we will perform a meta-analysis to identify and review the relationship between urinary BPA concentrations and IVF outcomes.Methods and analysisA comprehensive literature search will be performed in PubMed, Web of Science and the Cochrane central register of controlled trials for relevant articles using MeSH terms and related entry terms (up to 20 April 2022). The language will be restricted to English. Articles will be screened for inclusion in or exclusion from the study independently by two reviewers after removing the duplicates. The titles and abstracts followed by full-text screening will also be conducted independently by two reviewers. In addition, the references of the included literature will also be traced to supplement our search results and to obtain all relevant literature. The Newcastle-Ottawa Scale will be used to assess the methodological quality of the included studies using a star rating system ranging from 0 to 9 stars. Heterogeneity in estimates from different articles will be quantified, and publication bias will be investigated using funnel plots. Finally, a sensitivity analysis will also be conducted to estimate whether our results could have been markedly affected by a single included study.Ethics and disseminationEthical approval is not required for this protocol, as participants are not included. Findings will be disseminated through peer-reviewed publications and conference presentations.
Digitally distributed Yoga Intervention in Breast Cancer Rehabilitation (DigiYoga CaRe): protocol for a randomised controlled trial
Authors: Ohlsson Nevo Emma , Arvidsson-Lindvall MiaLinn , Hellerstedt Börjeson Susanne , Hagberg Lars , Hultgren Hörnqvist Elisabeth , Valachis Antonios , Wickberg Åsa , Duberg Anna 
Published: November 2022

IntroductionBreast cancer is the most prevalent cancer among women. The treatment is extensive; in addition to surgery, various combinations of radiation therapy, chemotherapy and antibody and endocrine treatment can be applied. Cancer-related fatigue (CRF) is high in patients with breast cancer, peaking during chemotherapy, but may persist for several years. Physical activity has proven to be effective in reducing CRF in breast cancer rehabilitation, but many patients tend to be less active after the diagnosis. Yoga has a previously demonstrated effect on energy levels and digitally distributed yoga intervention can potentially increase accessibility in pandemic times and facilitate participation for patients susceptible to infection and those living far from organised rehabilitation opportunities. The purpose of this study, Digital Yoga Intervention in Cancer Rehabilitation (DigiYoga CaRe) is to investigate whether a 12-week digitally distributed yoga intervention can reduce CRF and stress, improve health-related quality of life (HRQL) and affect pro-inflammatory and metabolic markers in patients with breast cancer.Methods and analysisThis multicentre study will adopt a randomised controlled design including 240 persons after their breast cancer surgery. They will be randomised to a 12-week digitally distributed yoga intervention or to a control group. The intervention group practice yoga two times a week, one yoga class live-streamed to the patient’s computer or mobile device and one prerecorded video class for self-training. The controls receive standardised care, gift cards for flowers and access to yoga video links after the data collection has ended. The primary analysis will be performed following the principle of intention to treat. Data will be collected by questionnaires, blood samples, accelerometers and interviews.Ethics and disseminationThe DigiYoga CaRe study was approved by the Regional Ethical Review Board in Lund. The final results of this study will be disseminated to conference, patient and public involvements and peer-reviewed publications.Trial registration numberNCT04812652.
Thrombus migration in ischemic stroke due to large vessel occlusion: a question of time
Authors: Riegler Christoph , Siebert Eberhard , Kleine Justus F , Nolte Christian H 
Published: November 2022

BackgroundThrombus migration (TM) is frequently observed in large vessel occlusion (LVO) ischemic stroke to be treated by endovascular thrombectomy (EVT). TM may impede complete recanalization and hereby worsen clinical outcomes. This study aimed to delineate factors associated with TM and clarify its impact on technical and functional outcome.MethodsAll patients undergoing EVT due to LVO in the anterior circulation at two tertiary stroke centers between October 2015 and December 2020 were included. Source imaging data of all individuals were assessed regarding occurrence of TM by raters blinded to clinical data. Patient data were gathered as part of the German Stroke Registry, a multicenter, prospective registry assessing real-world outcomes. Technical outcome was assessed by modified Thrombolysis in Cerebral Infarction scale (mTICI). Functional outcome was assessed by modified Rankin Scale (mRS) at 3 months.ResultsThe study consisted of 512 individuals, of which 71 (13.8%) displayed TM. In adjusted analyses, TM was associated with longer time from primary imaging to reassessment in the angio suite (aOR 2.37 (1.47 to 3.84) per logarithmic step) and intravenous thrombolysis (IVT; aOR 4.07 (2.17 to 7.65)). In individuals with IVT, a needle-to-groin time >1 hour was associated with higher odds for TM (aOR 2.60 (1.20 to 5.99)). TM was associated with lack of complete recanalization (aORmTICI30.46 (0.24 to 0.90)) but TM did not worsen odds for good clinical outcome (aORmRS≤2_d900.89 (0.47 to 1.68)).ConclusionsTM is associated with IVT and longer time between sequential assessments of thrombus location. Consequently, TM may be of high relevance in patients with drip-and-ship treatment.
The invariant action for solitonic 5-branes
Authors: Molina Jeffrey , Musaev Edvard 
Published: November 2022

AbstractWe construct the full effective action including DBI and WZ terms for solitonic 5-branes covariant under T-duality. The result is a completion of results known in the literature to a full T-duality covariant expression. The covariant WZ action includes previously omitted R–R terms. The obtained full covariant effective action reproduces the one obtained by S-duality from the D5-brane upon the correct choice of the covariant charge.
Higgs boson decays $$h\rightarrow Z \gamma $$ and $$h\rightarrow m_V Z$$ in the $$U(1)_X$$SSM
Authors: Wang Xi , Zhao Shu-Min , Wang Tong-Tong , Su Lu-Hao , Li Wei , Zhang Ze-Ning , Yang Zhong-Jun , Feng Tai-Fu 
Published: November 2022

AbstractWe present a detailed analysis of the Higgs boson decays $$h\rightarrow Z \gamma $$

h
→
Z
γ

and $$h\rightarrow m_V Z$$

h
→

m
V

Z

in the $$U(1)_X$$

U

(
1
)

X

SSM, with $$m_V$$

m
V

denoting one of the mesons ($$\omega ,\rho ,\phi ,J/{\psi },\Upsilon $$

ω
,
ρ
,
ϕ
,
J
/
ψ
,
Υ

). Using the effective Lagrangian method, we calculate the effective constants $$C_{\gamma Z}$$

C

γ
Z

(CP-even) and $${\tilde{C}}_{\gamma Z}$$

C
~

γ
Z

(CP-odd) for the vertex $$h \gamma Z$$

h
γ
Z

, which are corrected by the new particle loop diagrams. Numerically, the ratio $${\Gamma }_{U(1)_X}(h\rightarrow Z \gamma )/{\Gamma }_{SM}(h\rightarrow Z \gamma )$$

Γ

U

(
1
)

X

(
h
→
Z
γ
)

/

Γ

SM

(
h
→
Z
γ
)

is between 1.02 and 1.35. For the vector mesons $$\omega ,\rho ,\phi $$

ω
,
ρ
,
ϕ

and $$J/{\psi }$$

J
/
ψ

, the ratios $${\Gamma }_{U(1)_X}(h\rightarrow m_V Z )/{\Gamma }_{SM}(h\rightarrow m_V Z)$$

Γ

U

(
1
)

X

(
h
→

m
V

Z
)

/

Γ

SM

(
h
→

m
V

Z
)

are mainly distributed in the range of (1.01–1.45). When $$m_V$$

m
V

represents $$\Upsilon $$
Υ
, the ratio $${\Gamma }_{U(1)_X}(h\rightarrow \Upsilon Z )/{\Gamma }_{SM}(h\rightarrow \Upsilon Z)$$

Γ

U

(
1
)

X

(
h
→
Υ
Z
)

/

Γ

SM

(
h
→
Υ
Z
)

is mostly located in the range of (1.002–1.30). The aim of this work is to provide a reference for probing the $$U(1)_X$$

U

(
1
)

X

SSM model via the Higgs decays $$h\rightarrow Z \gamma $$

h
→
Z
γ

and $$h\rightarrow m_V Z$$

h
→

m
V

Z

.
Prognostic Impact of Unsupervised Early Assessment of Bulk and Leukemic Stem Cell Measurable Residual Disease in Acute Myeloid Leukemia
Authors: Canali Alban , Vergnolle Inès , Bertoli Sarah , Largeaud Laetitia , Nicolau Marie-Laure , Rieu Jean-Baptiste , Tavitian Suzanne , Huguet Françoise , Picard Muriel , Bories Pierre , Vial Jean Philippe , Lechevalier Nicolas , Béné Marie Christine , Luquet Isabelle , Mansat-De Mas Véronique , Delabesse Eric , Récher Christian , Vergez François 
Published: November 2022

Abstract

Purpose:
Acute myeloid leukemias (AML) are clonal diseases that develop from leukemic stem cells (LSC) that carry an independent prognostic impact on the initial response to induction chemotherapy, demonstrating the clinical relevance of LSC abundance in AML. In 2018, the European LeukemiaNet published recommendations for the detection of measurable residual disease (Bulk MRD) and suggested the exploration of LSC MRD and the use of multiparametric displays.

Experimental Design:
We evaluated the performance of unsupervised clustering for the post-induction assessment of bulk and LSC MRD in 155 patients with AML who received intensive conventional chemotherapy treatment.

Results:
The median overall survival (OS) for Bulk+ MRD patients was 16.7 months and was not reached for negative patients (HR, 3.82; P &lt; 0.0001). The median OS of LSC+ MRD patients was 25.0 months and not reached for negative patients (HR, 2.84; P = 0.001). Interestingly, 1-year (y) and 3-y OS were 60% and 39% in Bulk+, 91% and 52% in Bulk-LSC+ and 92% and 88% in Bulk-LSC−.

Conclusions:
In this study, we confirm the prognostic impact of post-induction multiparametric flow cytometry Bulk MRD in patients with AML. Focusing on LSCs, we identified a group of patients with negative Bulk MRD but positive LSC MRD (25.8% of our cohort) with an intermediate prognosis, demonstrating the interest of MRD analysis focusing on leukemic chemoresistant subpopulations.
Validity and Reliability of the Turkish Version of the KIDSCREEN-27 for Individuals With Cerebral Palsy
Authors: Bingol Hasan , Gunel Mintaze Kerem , Asena Sel Sinem , Burc Eda , Fidan Hande 
Published: November 2022

Our aims in this study were to examine the construct/concurrent validity and internal/test-re-test reliabilities of both the self-report and parent-report questionnaires of a Turkish version of the KIDSCREEN-27 for adolescents with cerebral palsy (CP). We used a convenience sample of 135 children and adolescents with CP aged 8–18 years (65 males, 70 females; M age = 12.39, SD = 3.57) and their parents/caregivers (123 mothers, seven fathers, and five grandmothers). We explored structural construct validity via confirmatory factor analysis (CFA). Concurrent validity was examined via Spearman’s correlations between the KIDSCREEN-27 questionnaires and the self-report and primary caregiver report forms of the Cerebral Palsy Quality of Life for Children (CP QOL-Child) and adolescents (CP QOL-Teen). We explored test-retest and internal consistency reliabilities utilizing intraclass correlation coefficients (ICC) and Cronbach’s alpha (α), respectively. CFA goodness-of fit indices verified that the predefined model of the KIDSCREEN-27 was a good fit for data from the CP population (X2/df<5, GFI >0.90, AGFI >0.90, RMSEA<0.80). Results showed the subdomains of both KIDSCREEN-27 forms to be significantly correlated with the matched subdomains of the CP QOL-Child and CP QOL-Teen questionnaires (ranges of r = 0.62–0.94). Overall, α and ICC coefficients for all subdomains of both KIDSCREEN-27 versions were acceptable (α and ICC >0.70). Both versions of the KIDSCREEN-27 have satisfactory psychometric properties for use in evaluating health-related quality of life (HRQOL) outcomes in children and adolescents with CP.
Survival comparison of different histological subtypes of oropharyngeal squamous cell carcinoma: A propensity-matched score analysis based on SEER database
Authors: Li Tao , Wang Yi , Xiang Xianwang , Chen Chuanjun 
Published: November 2022

ObjectiveThe purpose of this study was to analyze the difference of survival rates in paitents with oropharyngeal keratinizing squamous cell carcinoma (KSCC), nonkeratinizing squamous cell carcinoma (NKSCC), basaloid squamous cell carcinoma (BSCC), and papillary squamous cell carcinoma (PSCC).Materials and methodsPatients diagnosed with oropharyngeal squamous cell carcinoma between 2004 and 2015 were collected from the SEER database. Cox proportional hazards models and Kaplan–Meier curves were used for survival analysis. Propensity score matching (PSM) was performed to adjust for the effect of confounding variables. Due to the small sample size of PSCC, this study did not perform PSM between it and other subtypes.ResultsThe 5-year cancer-specific survival (CSS) rate of PSCC was higher than that of KSCC, NKSCC, and BSCC (0.627 vs. 0.812 vs. 0.789 vs. 0.875, P < 0.05); And the CSS rate of KSCC was lower than that of other subtypes both before and after PSM. In addition, the 5-year and 10-year CSS rates of BSCC were not different from NKSCC ( P > 0.05), but not as good as NKSCC in the long term ( P = 0.028). After PSM, the 5-year, 10-year, and long-term prognosis of BSCC were significantly worse than those of NKSCC ( P < 0.001).ConclusionThe 5-year CSS of PSCC was better than the other three subtypes. The short-term prognosis of BSCC was not significantly different from NKSCC, but the long-term survival was lower than that of NKSCC, and the difference was more obvious after PSM. Meanwhile, the prognosis of KSCC was worst.
A novel use of CT attenuation value: increased bone marrow density in patients with acute myeloid leukemia
Authors: Kumasaka Soma , Kubota Jun , Kumasaka Yuka , Naito Chiaki , Tsushima Yoshito 
Published: November 2022

Background Acute myeloid leukemia (AML) is the most common type of acute leukemia in adults. Bone marrow computed tomography (CT) attenuation may increase in patients with myeloproliferative disorders; however, the actual threshold CT attenuation value predictive of myeloproliferative has not been reported. Purpose To determine whether the unenhanced CT attenuation value of the bone marrow may be useful for predicting AML. Material and Methods We retrospectively analyzed patients with AML (n = 56) who underwent unenhanced CT before treatment, and age- and sex-matched controls without any hematologic disease. For each patient, the CT attenuation value (HU) of the iliac bone was measured and compared between the two groups. Receiver operating characteristic (ROC) curve analysis was used to define the cutoff value for predicting AML on all patients, and only on late elderly patients (aged ≥75 years). Results Patients with AML showed higher bone marrow CT attenuation value (131.4 ± 58.3 vs. 53.9 ± 67.2 HU; P < 0.001), compared to the controls. The sensitivity and specificity for the diagnosis of AML in all patients were 78.6% and 80.4%, respectively, at a threshold value of 90 HU, whereas they were 83.3% and 91.7%, respectively, at 40 HU in late elderly patients. Conclusion The iliac bone CT attenuation value was elevated in patients with AML and may be useful for predicting AML.
Computed tomography findings in bronchial asthma: quantification of air trapping and correlation with pulmonary function tests
Authors: Ghosh Subha 
Published: November 2022

Background High-resolution computed tomography (HRCT) scans can help identify subsets of asthma patients who show rapid decline in lung function. Purpose To evaluate high-resolution computed tomography (HRCT) findings in adult patients with asthma, obtain quantitative measurements of air trapping on expiratory scans, and correlate the findings with pulmonary function tests (PFTs). Material and Methods Thirty adults with asthma with persistent-mild, persistent-moderate, and persistent-severe categories as per standard clinical guidelines were evaluated with inspiratory and expiratory HRCT for various imaging features of bronchial asthma. Expiratory HRCT scan were used to quantify degree of air-trapping, and their values quantified as “pixel index,” using a special “density' mask” software. Complete spirometry and body plethysmography were performed on each patient within 0–2 days of HRCT scans. HRCT findings were correlated with the clinical severity groups and the CT pixel indices (PI) were correlated with the PFT results using correlation coefficients and linear regression analysis. Results The inspiratory CT findings did not correlate with increase in disease severity. Expiratory scans accurately quantified areas of air trapping. CT-PI correlated well with PFT values indicative of airway obstruction and airflow limitation, which helped differentiate patients with asthma with increasing severity from those with milder forms of the disease. Conclusion Expiratory thin-section CT is a useful objective method to quantify air-trapping in people with asthma. The air-trapping score measured in “pixel indices” correlates well with PFT results and can successfully identify patients with severe asthma. Further studies are needed to confirm if this parameter can serve as a potential marker for airway remodeling and declining lung function.
Measuring pure ground-glass nodules on computed tomography: assessing agreement between a commercially available deep learning algorithm and radiologists’ readings
Authors: Zuo Zhichao , Wang Peng , Zeng Weihua , Qi Wanyin , Zhang Wei 
Published: November 2022

Background Deep learning algorithms (DLAs) could enable automatic measurements of solid portions of mixed ground-glass nodules (mGGNs) in agreement with the invasive component sizes measured during pathologic examinations. However, the measurement of pure ground-glass nodules (pGGNs) based on DLAs has rarely been reported in the literature. Purpose To evaluate the use of a commercially available DLA for the automatic measurement of pGGNs on computed tomography (CT). Material and Methods In this retrospective study, we included 68 patients with 81 pGGNs. The maximum diameter of the nodules was manually measured by senior radiologists and automatically segmented and measured by the DLA. Agreement between the measurements by the radiologist and DLA was assessed using Bland–Altman plots, and correlations were analyzed using Pearson correlation. Finally, we evaluated the association between the radiologist and DLA measurements and the invasiveness of lung adenocarcinoma in patients with pGGNs on preoperative CT. Results The radiologist and DLA measurements exhibited good agreement with a Bland-Altman bias of 3.0%, which were clinically acceptable. The correlation between both sets of maximum diameters was also strong, with a Pearson correlation coefficient of 0.968 ( P < 0.001). In addition, both sets of maximum diameters were larger in the invasive adenocarcinoma group than in the non-invasive adenocarcinoma group ( P < 0.001). Conclusion Automatic pGGNs measurements by the DLA were comparable with those measured manually and were closely associated with the invasiveness of lung adenocarcinoma.
Multi-cancer early detection test sensitivity for cancers with and without current population-level screening options
Authors: Shao Spencer H. , Allen Brian , Clement Jessica , Chung Gina , Gao Jingjing , Hubbell Earl , Liu Minetta C. , Swanton Charles , Tang W.H. Wilson , Yimer Habte , Tummala Mohan 
Published: November 2022

There are four solid tumors with common screening options in the average-risk population aged 21 to 75 years (breast, cervical, colorectal, and, based on personalized risk assessment, prostate), but many cancers lack recommended population screening and are often detected at advanced stages when mortality is high. Blood-based multi-cancer early detection tests have the potential to improve cancer mortality through additional population screening. Reported here is a post-hoc analysis from the third Circulating Cell-free Genome Atlas substudy to examine multi-cancer early detection test performance in solid tumors with and without population screening recommendations and in hematologic malignancies. Participants with cancer in the third Circulating Cell-free Genome Atlas substudy analysis were split into three subgroups: solid screened tumors (breast, cervical, colorectal, prostate), solid unscreened tumors, and hematologic malignancies. In this post hoc analysis, sensitivity is reported for each subgroup across all ages and those aged ⩾50 years overall, by cancer, and by clinical cancer stage. Aggregate sensitivity in the solid screened, solid unscreened, and hematologic malignancy subgroups was 34%, 66%, and 55% across all cancer stages, respectively; restricting to participants aged ⩾50 years showed similar aggregate sensitivity. Aggregate sensitivity was 27%, 53%, and 60% across stages I to III, respectively. Within the solid unscreened subgroup, aggregate sensitivity was >75% in 8/18 cancers (44%) and >50% in 13/18 (72%). This multi-cancer early detection test detected cancer signals at high (>75%) sensitivity for multiple cancers without existing population screening recommendations, suggesting its potential to complement recommended screening programs. Clinical trial identifier: NCT02889978.
Paramedic use and understanding of their professional code of conduct
Authors: Collings-Hughes Derek , Townsend Ruth , Williams Brett 
Published: November 2022

Background Paramedicine is a newly regulated profession in Australia and with the introduction of regulation in 2018 for this profession came increased responsibilities – including the introduction of a professional code of conduct. Several countries now have regulation of paramedicine and associated professional codes to guide ethical and professional behaviour. Despite this, there has been no published research into paramedic understanding and use of their professional codes. Objectives To explore Australian paramedics’ use and understanding of their professional code of conduct. Research design: This study used a qualitative descriptive design, underpinned by hermeneutic theory. Reflexive thematic analysis was used to analyse the interview data and identify Australian paramedic perceptions surrounding the use of their code of conduct. Results 11 Registered Paramedics from several states and territories were interviewed. Participants were invited to interview by advertisement on social media and the Australasian College of Paramedicine Web site. Participants had varied professional backgrounds including clinical work, education providers and policymakers/managers. Four themes were identified as follows: Theme 1 – ‘You don’t know, what you can’t know’; Theme 2 – ‘I don’t need the code – the code is for others’; Theme 3 – ‘It’s about time’; Theme 4 – ‘Navigating the new profession’. Ethical considerations: Ethics approval was granted by the Monash University Human Research Ethics Committee (MUHREC) Project ID: 28921. All participants provided informed consent. Conclusions The results of this study suggest that paramedics’ knowledge and use of their code is limited, and participants appeared to mostly rely instead on ‘common sense’ morals. Participants did appear to want to understand the broad concepts of the code more and have this better integrated into the profession. The code was also interpreted as important to the paramedic profession and its new professional status, helping to legitimise it as a health profession in Australia.