bluuebunny/crossref_metadata_2025_split huggingface dataset:
Human papillomavirus (HPV) detection in vaginal self-samples: evaluation of eNat® as an alternative suspension medium to ThinPrep®PreservCyt® for vaginal swabs
Authors: Giubbi Chiara , Martinelli Marianna , Vallini Ivan , Paganoni Silvia , Dafa'alla Tarig , Perdoni Federica , Musumeci Rosario , Wu Winnie , Castriciano Santina , Romano Paolo , Cocuzza Clementina E. 
Published: July 2022

Human Papillomavirus (HPV) testing on self-collected samples allows for improved coverage rates of cervical cancer (CC) screening programs. ThinPrep®PreservCyt® (HOLOGIC®, USA) medium is widely used for the suspension of cervical and vaginal self-samples. However, this medium is costly, toxic, and flammable, involving special handling procedures which make its use difficult in screening programs, particularly in low- and middle-income countries. This pilot study aimed to evaluate the analytical performance of eNat® (Copan SpA), an alternative non-alcohol-based suspension medium, compared to ThinPrep®PreservCyt® (HOLOGIC®) for high-risk HPV (hrHPV) detection in vaginal self-collected swabs using three different real-time polymerase chain reaction (RT-PCR) HPV assays: Anyplex™II HPV28 (Seegene, Korea), Papilloplex® High Risk HPV (GeneFirst, UK), and HPV OncoPredict (Hiantis, Italy). 30 women, referred to colposcopy, were enrolled in this observational, prospective pilot study and asked to collect two vaginal self-taken samples, which were suspended in 5 mL of ThinPrep®PreservCyt® or eNat®. Nucleic acids were extracted from 200 μL using Microlab Nimbus platform (Seegene, Korea) and tested with the three different RT-PCR full-genotyping high-risk HPV assays. The HPV results of vaginal samples resuspended in the two different media were compared to those obtained from the reference clinician-collected cervical sample from the same woman. hrHPV detection in vaginal self-samples suspended in both media demonstrated a substantial agreement with cervical samples with the three assays under-investigation (0.667<k<0.796). Moreover, the discordances between vaginal self-samples collected from the same woman were found only in cases of normal cytology or low-grade cytological lesions and were generally related to low hrHPV viral loads as indicated by the quantitative HPV OncoPredict assay (6.24E+02 copies/10,000 cells). The study's preliminary findings demonstrated a very good agreement between cervical and vaginal self-collected samples suspended in ThinPrep®PreservCyt® and eNat®, suggesting that the latter could represent a good alternative medium in HPV screening programs based on self-collection.
An exploration of prenatal breastfeeding self-efficacy: a scoping review protocol
Authors: McGovern Liz , Geraghty Aisling , McAuliffe Fionnuala , O'Reilly Sharleen 
Published: July 2022

Objective: To synthesise the evidence on prenatal breastfeeding self-efficacy, including identifying concepts and theoretical frameworks that underpin its development, the evidence on its measurement, interventions used to improve it, and association with breastfeeding outcomes. Background: Breastfeeding self-efficacy is described as a woman’s self-belief and confidence in her perceived ability to breastfeed. It is a modifiable measure that is strongly associated with breastfeeding outcomes such as initiation, exclusivity, and duration. Interventions aimed at increasing self-efficacy are often in the postnatal period and have been shown to be effective at improving breastfeeding outcomes. The prenatal period appears to be underexplored in the literature and yet focusing on enhancing it may have the potential for further improvements in self-efficacy and on subsequent breastfeeding outcomes. A comprehensive knowledge synthesis on prenatal breastfeeding self-efficacy is lacking. Methods: The search will include databases across health, psychology, sociology, and the grey literature on breastfeeding guidance. Once the PCC framework (Problem: breastfeeding, Concept: self-efficacy, Context: prenatal period) is met, sources of evidence from any contextual setting will be eligible for inclusion. Limits will not be applied on geographic location or year of publication. The PRISMA-ScR flow diagram of search and study selection will be used to report final figures. Two independent reviewers will perform title and abstract screening, full-text review, and data extraction. Data will be charted to provide a logical and descriptive summary of the results that align with the objectives. Conclusion: The results will provide an understanding of what has been done in the space and what gaps exist, informing recommendations for the timing of measurement and the design of prenatal interventions.
A Philosophical Analysis of the Recent Controversy about “Islamo-leftism” in French Academia
Authors: Stamenkovic Philippe 
Published: July 2022

In February 2021, the French Minister of Higher Education and Research, Frédérique Vidal, ordered an inquiry – to be led by the French National Centre for Scientific Research – about the alleged “Islamo-leftism” (islamo-gauchisme) which, according to her, was corrupting French academia. Vidal's concern was, purportedly, to distinguish “what falls under academic research and what falls under militancy and opinion”. She had in mind, in particular, recent interdisciplinary fields in the social sciences, such as Postcolonial Studies. Her statements caused a controversy in French academia as well as outside. The goal of this paper is to present this controversy and analyse it in light of the philosophical literature on autonomy of, and values in, science.
After recalling the political and institutional context of the controversy (1st part), I present Vidal’s intervention (2nd part) and various reactions to it, which can roughly be classified pro and contra Vidal's statements (3rd part). I then provide a philosophical discussion of the controversy (4th part), by recalling the philosophical debate to which it is related (the autonomy of, and the values in science), and analysing the assumptions, arguments and actions of both camps. I show in particular that a political intervention inside the very production of academic knowledge implies a strong risk of censorship (whether self-inflicted, intra-academic or extra-academic), and that letting academia self-regulate itself with respect to the validation of knowledge remains the best way to go. I conclude with the deeper questions raised by this controversy: the social role of universities, and the institutional aspects of scientific knowledge validation.
Optimizing the First Response to Sepsis: An Electronic Health Record-Based Markov Decision Process Model
Authors: Rosenstrom Erik , Meshkinfam Sareh , Ivy Julie Simmons , Goodarzi Shadi Hassani , Capan Muge , Huddleston Jeanne , Romero-Brufau Santiago 
Published: July 2022

Sepsis is considered a medical emergency where delays in initial treatment are associated with increased morbidity and mortality, yet there is no gold standard for identifying sepsis onset and thus treatment timing. We leverage electronic health record (EHR) data with clinical expertise to develop a continuous-time Markov decision process (MDP) optimal stopping model that identifies the optimal first intervention action (anti-infective, fluid, or wait). To study the impact of initial treatment of patients at risk for developing sepsis, we define the delayed treatment population who received delayed treatment upon admission or during hospitalization and serves as an approximation of the natural history of sepsis. We apply the optimal first treatment policy to sample patient visits from the nondelayed treatment population. This analysis indicates the average risk of death could be reduced by approximately 2.2%, the average time until treatment could be reduced by 106 minutes, and the average severity of the treatment state could be reduced by 15.5% compared with the treatment they received in the hospital. We study the properties of the optimal policy to define an easily interpretable initial treatment heuristic that considers a patient’s organ dysfunction, location, and septic shock status. This generalizable framework can inform personalized treatment of patients at risk for sepsis. History: This paper has been accepted for the Decision Analysis Special Issue on Emerging Topics in Health Decision Analysis. Funding: This material is based upon work supported by the National Science Foundation [Grant 1522107 (North Carolina State University), 1522106 (Mayo Clinic), and 1833538 (Drexel University)].
When Worse Is Better: Strategic Choice of Vendors with Differentiated Capabilities in a Complex Cocreation Environment
Authors: Gupta Shubham , Roy Abhishek , Kumar Subodha , Mudambi Ram 
Published: July 2022

The growing complexity of consulting, new product development, and information technology projects has led firms to increasingly adopt the strategy of collaborative value cocreation with their vendors. Although such value cocreation often involves a client firm engaging with more than one vendor, research in this field has primarily focused on single-vendor cocreation, whereas research on multivendor sourcing has rarely considered collaborative value cocreation. We bridge this gap by studying a cocreation environment involving a client, a primary vendor, and a potential secondary vendor. Examining the trade-offs that arise in the strategic interactions among the three firms, we derive novel insights about how these interactions differ from those under one-vendor cocreation, and from those under traditional multivendor sourcing. Specifically, we demonstrate that the client can sometimes be better off by adding a secondary vendor that is less efficient than the primary one; and a more expensive primary vendor can sometimes make the client less inclined to add the secondary vendor. The client’s decision to add the secondary vendor is driven by the value per unit of output rather than purely cost or efficiency parameters. We show that in such collaborative environments, the primary vendor benefits from the addition of a secondary vendor whenever it benefits the client. The conceptual and managerial insights drawn from our research contribute to a better theoretical and practical understanding of strategic decision making by firms in multivendor cocreation environments that are increasingly becoming prevalent. This paper was accepted by Jayashankar Swaminathan, operations management. Supplemental Material: Data and the e-companion are available at https://doi.org/10.1287/mnsc.2022.4490 .
CPD article: How to create a dog friendly clinic
Authors: Stagg Malcolm 
Published: July 2022

For many reasons, dogs can find visiting the veterinary surgery challenging. This article discusses the need to understand dogs' feelings and observe their body language, providing examples of how the veterinary environment might impact canine emotional wellbeing. Recommendations are provided for stress reduction adaptations to improve the veterinary experience. Approaches to handling are also discussed, including the importance of considering the dog's perspective of these. The use of low stress handling techniques are promoted, with examples provided for common clinical treatment and necessary interactions, as well as general guiding principles. The importance of the owner within the dog's lifelong veterinary journey is also highlighted, with considerations including owner emotional state, ability to support their dog emotionally, and knowledge of their dog's normal reactions. Preventative measures to better prepare a dog for the clinic environment, such as puppy appointments, are alluded to with references to detailed resources provided.
Chair Development on the Basis of Body Pressure Distribution—A Research Effort*
Authors: Denes Levente , Bencsik Balazs , Horvath Peter Gyorgy , Antal Reka Maria 
Published: July 2022

Abstract
Surveys and studies show that more and more employees perform high- or low-skilled white-collar work predominantly in sitting postures. Therefore, comfortable sitting plays an important role in reducing the risk of musculoskeletal disorders and other harmful effects. Research efforts focus on reducing these risks by designing ergonomic chairs with multiple adjustment possibilities, allowing the chair to fit to the user's body shape or assuring a dynamic seating where the user's lower body is in continuous movement. This article summarizes the results of a research effort that evaluated the effect of several factors on sitting comfort based on body pressure distribution. The effects of foam elasticity, foam layer arrangement order, and seat support elasticity were investigated as well as the chair seat type (kneeling chair, saddle chair). Results were used to determine the optimal chair cushion including the layered foam system and seat support type. On the basis of our findings a new ergonomic chair was developed combining the advantages of static and dynamic sitting.
Evidence-Based Early Home Visiting for Mothers and Parents With Intellectual Disability: Home Visitor Perceptions and Practices
Authors: West Allison L. , Dibble Kate E. 
Published: July 2022

Abstract
Evidence-based maternal, infant, and early home visiting (EBHV) is a potential strategy to support parent and child health and well-being among families headed by a parent with an intellectual disability (ID). Little is known about the capacity of EBHV programs to meet the needs of parents with ID effectively. This study examined home visitor practices and perceptions of services for parents with ID. Home visiting staff recruited from a national practice-based research network participated in web-based surveys. Practices and perceptions varied widely across sites and were associated with home visitor knowledge and self-efficacy and site implementation supports, such as policies, curricula, and community collaboration. More work is needed to understand and strengthen EBHV services for parents with ID.
Demographic profiles of contact lens wearers and their association with lens wear characteristics in Trinidad and Tobago: A retrospective study
Authors: Ezinne Ngozika E. , Bhattarai Dipesh , Ekemiri Kingsley K. , Harbajan Gabrielle N. , Crooks Anesha C. , Mashige Khathutshelo P. , Ilechie Alex A. , Zeried Ferial M. , Osuagwu Uchechukwu L. 
Published: July 2022

Purpose
Contact lenses (CL) remain a popular mode of refractive error correction globally and in the Caribbean, mostly among young people. However, no data on the characteristics of the CL population wearers in the Caribbean is available. This study reported on the characteristics of CL wearers and the associated factors in Trinidad and Tobago (T&T).

Methods
This retrospective study reviewed the clinical records of 243 CL wearers who attended the University of the West Indies (UWI) optometry clinic between 2017 and 2018. Data on their demographic profiles, CL wearing characteristics including lens type, material, purpose of wear, replacement schedule and lens care systems were extracted and analyzed. The associations between the demographic characteristics and CL wearing characteristics were also determined.

Results
About half of the CL wearers used them for fashion (more among those aged 18 to 30 years, 61.0%), therapeutic (more among those <18 years, 43.8%, P = 0.001) and refractive error correction purposes (more in those >40 years, P = 0.001). Females were more likely to use CLs for fashion compared with males (67.0% versus 40.7%). Age (P<0.0005) and gender (P = 0.030) were associated with the lens materials. Those aged 18–30 years were more likely use hydrogels compared with the younger ones (64.1% versus 25.0%). Rigid gas permeable (RGP) CL use was more common in males than females (21.8% versus 10.9%, P = 0.031). Daily disposables were predominantly used by younger respondents (18–30 years old, 31.3%, P < 0.001) and more in females than males (66.7% vs 49.4%, P = 0.040).

Conclusion
The study found that the CL appears to be more commonly worn for fashion in younger females and for refractive error correction in older males. Age, gender, and employment status were the main determinants of lens wear among respondents attending the university clinic in T&T.
Hospital length of stay among children with and without congenital anomalies across 11 European regions—A population-based data linkage study
Authors: Urhoj Stine Kjaer , Tan Joachim , Morris Joan K. , Given Joanne , Astolfi Gianni , Baldacci Silvia , Barisic Ingeborg , Brigden Joanna , Cavero-Carbonell Clara , Evans Hannah , Gissler Mika , Heino Anna , Jordan Sue , Lutke Renée , Odak Ljubica , Puccini Aurora , Santoro Michele , Scanlon Ieuan , de Walle Hermien E. K. , Wellesley Diana , Zurriaga Óscar , Loane Maria , Garne Ester 
Published: July 2022

Background
Congenital anomalies are a leading cause of childhood morbidity, but little is known about the long-term outcomes.

Objective
To quantify the burden of disease in childhood for children with congenital anomalies by assessing the risk of hospitalisation, the number of days spent in hospital and proportion of children with extended stays (≥10 days).

Methods
European population-based record-linkage study in 11 regions in eight countries including children with congenital anomalies (EUROCAT children) and without congenital anomalies (reference children) living in the same regions. The children were born between 1995 and 2014 and were followed to their tenth birthday or 31/12/2015. European meta-analyses of the outcome measures were performed by two age groups, <1 year and 1–4 years.

Results
99,416 EUROCAT children and 2,021,772 reference children were linked to hospital databases. Among EUROCAT children, 85% (95%-CI: 79–90%) were hospitalised in the first year and 56% (95%-CI: 51–61%) at ages 1–4 years, compared to 31% (95%-CI: 26–37%) and 25% (95%-CI: 19–31%) of the reference children. Median length of stay was 2–3 times longer for EUROCAT children in both age groups. The percentages of children with extended stays (≥10 days) in the first year were 24% (95%-CI: 20–29%) for EUROCAT children and 1% (95%-CI: 1–2%) for reference children. The median length of stay varied greatly between congenital anomaly subgroups, with children with gastrointestinal anomalies and congenital heart defects having the longest stays.

Conclusions
Children with congenital anomalies were more frequently hospitalised and median length of stay was longer. The outlook improves after the first year. Parents of children with congenital anomalies should be informed about the increased hospitalisations required for their child’s care and the impact on family life and siblings, and they should be adequately supported.
Translation, cross-cultural adaptation, and validation of the Chinese version of self-efficacy and attitudes for providing Mouth Care scale
Authors: Chen Lan , Gu Liyan , Li Xianchen , Chen Wenyao , Zhang Lingjuan 
Published: July 2022

Background
In recent years, oral care for older people has received extensive attention in long-term care facilities. The Self-Efficacy for Providing Mouth Care (SE-PMC) and Attitudes for Providing Mouth Care (A-PMC) scale evaluated the self-efficacy and attitude of nursing staff while providing oral care. However, whether this scale is valid and reliable for Chinese nursing staff in China remains unverified. This study aims to translate the English version of SE-PMC and A-PMC into Chinese and determine their reliability and validity.

Methods
After obtaining the author’s consent, the procedure for a double-back translation and cross-cultural adaptation was conducted to develop the Chinese version of SE-PMC and A-PMC. The validity and reliability of the Chinese version of SE-PMC and A-PMC were evaluated in a cross-sectional observational study with 852 nurses from 42 Geriatric Care Facilities (GCFs). Exploratory factor analysis (EFA) (n = 427) and confirmatory factor analysis (CFA) (n = 425) were conducted to test the construct validity and quality of the factor structures. We applied the item discrimination test and homogeneity test for item analysis. Cronbach’s alpha coefficient and split-half coefficient were adopted to evaluate internal consistency.

Results
The Chinese version of SE-PMC (11 items, 3 factors) and A-PMC (11 items, 2 factors) included 22 items, reflecting adequate construct validity and reliability. In addition, test-retest reliability was 0.809 for SE-PMC and 0.811 for A-PMC, evincing good stability. The Cronbach’s α coefficient of SE-PMC was 0.831, with each factor ranging from 0.793~0.906. The Cronbach’s α coefficient of the A-PMC was 0.768, with each factor ranging from 0.814~0.824. Item-Content Validity Index (I-CVI) of SE-PMC and A-PMC ranged from 0.84 ~1.00 and 0.82~1.00, respectively.

Conclusion
The Chinese version of SE-PMC and A-PMC was validated as a reliable assessment tool to evaluate the self-efficacy and attitude of nursing staff in GCFs for providing oral care in China.
Multiplex peptide microarray profiling of antibody reactivity against neglected tropical diseases derived B-cell epitopes for serodiagnosis in Zimbabwe
Authors: Vengesai Arthur , Naicker Thajasvarie , Midzi Herald , Kasambala Maritha , Mduluza-Jokonya Tariro L. , Rusakaniko Simbarashe , Mutapi Francisca , Mduluza Takafira 
Published: July 2022

Introduction
Peptides (B-cell epitopes) have broad applications in disease diagnosis and surveillance of pathogen exposure. In this framework, we present a pilot study to design and produce a peptide microarray for the integrated surveillance of neglected tropical diseases. The peptide microarray was evaluated against peptides derived from Ascaris lumbricoides, Necator americanus, Schistosoma haematobium, Schistosoma mansoni, Trichuris trichiura, Bacillus anthracis, Mycobacterium leprae, Wuchereria bancrofti, Rabies lyssavirus, Chlamydia trachomatis and Trypanosoma brucei.

Methods
S. haematobium was diagnosed using the urine filtration technique. S. mansoni, A. lumbricoides, N. americanus and T. trichiura were diagnosed using the Kato Katz and formal ether concentration techniques. Immunogenic peptides were retrieved from the Tackling Infection to Benefit Africa infectious diseases epitope microarray. Further peptides were predicted using ABCpred. IgG and IgM reactivity against the derived peptides were evaluated using peptide microarray multiplex immunoassays. Positive response was defined as fluorescence intensity ≥ 500 fluorescence units. Immunodominant peptides were identified using color-coded heat maps and bar graphs reflecting the obtained fluorescence signal intensities. Receiver Operating Characteristic analysis and Mann-Whitney-U test were performed to determine the diagnostic validity of the peptides.

Results
Species-specific responses with at least one peptide derived from each NTD pathogen were observed. The reactive peptides included; for S. haematobium, XP_035588858.1-206-220 and XP_035588858.1-206-220 immunodominant for IgG and IgM respectively, for S. mansoni, P20287.1-58-72 immunodominant for both antibodies and for T. trichiura, CDW52482.1-326-340 immunodominant for IgG and CDW57769.1-2017-2031 and CDW57769.1-1518-1532 immunodominant for IgM. According to ROC analysis most of the peptides selected were inaccurate; with AUC < 0.5. Some peptides had AUC values ranging from 0.5 to 0.5875 for both IgM and IgG suggesting no discrimination.

Conclusion
Multiplex peptide microarrays are a valuable tool for integrated NTDs surveillance and for screening parasites exposure in endemic areas. Species sero-reactivity observed in the study maybe indicative of exposure to the different NTDs parasites. However, although peptides with the least cross reactivity were selected there is need to validate the sero-reactivity with recombinant antigens and immune-blotting techniques such as western blotting.