bluuebunny/crossref_metadata_2025_split huggingface dataset:
General multi-soliton and higher-order soliton solutions for a novel nonlocal Lakshmanan-Porsezian-Daniel equation
Authors: Wang Minmin , Chen Yong 
Published: August 2022

Abstract
The inverse scattering transformation for a novel nonlocal Lakshmanan-Porsezian-Daniel (LPD) equation with rapidly decaying initial data is studied in the framework of Riemann-Hilbert problem. Firstly, a novel integrable nonlocal LPD equation corresponding to a 3&times;3 spectral operator is proposed and the corresponding Lax pair is given. Secondly, the inverse scattering process with a novel left-right 3&times;3 matrix Riemann-Hilbert(RH) problem is constructed. A large emphasis is placed on the analytical properties and symmetry relations for the Jost functions and scattering data, which are considerably different from the local ones. Due to the special symmetry properties for the nonlocal LPD equation, the zeros of the RHP problem are purely imaginary or occur in pairs. With different types and configuration of zeros, the soliton formula are provided and the rich dynamical behaviors for the three kinds of multisolitons for the novel nonlocal LPD equation are demonstrated. Third, by a technique of adding disrupted parameters and limiting process, the formula of higher-order solitons for the nonlocal LPD equation is exhibited and the plots of diversity higher-order solitons are displayed.
Mitochondrial gene expression profiles in PTG in the Amygdala of a PTSD Model Following Corticosterone Therapy
Authors: Li Xin , Woodward Geoffrey , Chen Jun , Zhang Lei , Hu Xian-zhang , Li Charles , Xing Evan , Su Yan A. , Li He 
Published: August 2022

Abstract
The metabolic and neuronal mechanisms underlying the development of posttraumatic growth (PTG) following corticosterone (CORT) therapy in patients with posttraumatic stress disorder (PTSD) are not well defined. In this study, we assess differential gene expression (DEG) profiles associated with mitochondrial function in the amygdala of a PTSD rodent model using a mitochondrial focused gene array chip for both metabolic and neuronal functions. Amygdala tissue samples were excised from four groups of rats (N = 10 each) including: non-stressed control, stressed alone, CORT therapy alone, and CORT therapy with stress. CORT plus stress took place over a three-day period. All groups were sacrificed and assessed after a total of 14 days. Total RNA was isolated, cDNA was synthesized, and gene expression levels were determined using a cDNA microarray. During the development of the anxiety symptom, equivalent to the delayed and exaggerated fear associated with PTSD, 111 DEGs were determined to be statistically significant (p < 0.01) in CORT therapy compared to non-stressed controls. 86 DEGs were determined to be statistically significantly in the CORT with stress administered group in the amygdala complex using stringent criteria (p < 0.01). Furthermore, ingenuity pathway analysis (IPA) revealed six signaling network pathways in the amygdala complex of the CORT + Stress group. As in the CORT + Stress group, the measurement of acoustic startle showed no significant difference in comparison to the control group. Thus, anxiety was mitigated, and resiliency was increased with CORT therapy. In addition, the Venn diagram analysis indicated that 55 DEGs in the stressed group had 13 DEGs independently non-effected by CORT therapy associated with neuronal signaling networks and 42 DEGs dependently effected by CORT therapy in the stressed group alone. Thus, information provided by a neuronal and metabolic gene array allowed us to determine the expression profile of mitochondrial genes in PTG associated with the amygdala complex of a rodent model of PTSD. This result provides further understanding of the metabolic and neuronal signaling mechanisms associated PTG in the development of PTSD.
Spectroscopy- based development and validation of analytical technique for simultaneous estimation of bilastine montelukast
Authors: Thakur Shivalika 
Published: August 2022

Abstract
Bilastine is a selective antagonist of the histamine H1 receptor. It binds to the H1 receptor and inhibits it from being activated, reducing allergy symptoms caused by the release of histamine from mast cells. As a result, it serves as antiallergenic, reducing allergy symptoms such nasal congestion and urticaria.Montelukast Sodium is a leukotriene receptor antagonist that binds to the CysLT type 1 receptor, assisting in the inhibition of any physiological activities of CysLTs such as LTC4, LTD4, and LTE4 at the receptor that may help asthma or allergic rhinitis. As a result, it's mostly used to treat and prevent asthma symptoms (such as wheezing and shortness of breath) as well as allergic rhinitis. Allergy rhinitis and mild to severe asthma are treated with a combination of both medicines. Analytical methods on Bilastine and Montelukast Sodium are discussed in this research. However, no ways for combining Bilastine with Montelukast Sodium are now available. Bilastine and Montelukast Sodium can be tested using UV, used to help design new analytical methods.
High interspecific competitiveness of the invasive plant Xanthium italicum Moretti severely reduces the yield and quality of Carthamus tinctorius L.
Authors: Hou Mingcai , Ma Xia , Ma Miao 
Published: August 2022

Abstract
To explore the impact of invasive weed Xanthium italicum Moretti on the economic crop Safflower, ﬁeld experiments were conducted, the growth-related characters and the relative intensity of competition between the two species was explored. The results showed that under monoculture conditions, the stem height, crown width, stem diameter and the biomass of X. italicum root, stem and leaves were 1.14, 1.96, 1.82, 4.42, 4.21 and 3.99 times as high as those of Safflower, respectively. When the two species coexisted, the growth related characters of Xanthium italiana were further significantly improved, while the growth related characters of safflower were significantly decreased. When coexisted with X. italicum, the corolla biomass, hydroxysafflor yellow A content of corolla, seed yields, 100-seed weight, and seed oil content of Safflower in the interplanted treatment 90.04%, 33.11%, 63.89%, 40.58%, and 25.61% lower than those in the monocultured treatment, respectively. Relative yield (RY) and Competitive balance index (CB) of X. italicum and Safflower showed that the interspecific competitiveness of X. italicum was significantly higher than that of Safflower. Under the competitive inhibition of X. italicum, not only the vegetative growth, but also the reproductive growth, yield, and quality of the economic organs of Safflower were significantly negatively impacted.
Magnitude of chest trauma mortality and associated factors among adult patients admitted at University of Gondar Comprehensive Specialized Hospital, North West Ethiopia, 2019
Authors: Taye Addisu , Mersha Lielt , Kindie Wetetnesh 
Published: August 2022

Abstract

Objective Globally, Chest trauma is one of the major contributors of morbidity and mortality among trauma patients. There are different studies conducted in Ethiopia about the prevalence of chest injury and overall trauma mortality but not mortality related to chest trauma. Therefore this study aimed to assess the magnitude of chest trauma mortality and associated factors among adult patients admitted at University of Gondar Comprehensive Specialized Hospital, North West Ethiopia, 2019. Results out of a total of 400 chest trauma patients about 7.2%( 95% confidence interval (CI) 4.8, 10.0) of them were died. Being aged [Adjusted odds ratio (AOR) = 3.52(1.46, 8.48)], having associated injury [AOR = 4.23(1.49, 12.01)], late presentation [AOR = 2.93(1.22, 7.04)] and having complications [AOR = 4.43(1.9, 10.3)] were significantly significant with chest trauma mortality.
An efficient preparation and biocatalytic synthesis of novel C-glycosylflavonols kaempferol 8-C-glucoside and quercetin 8-C-glucoside by metabolic engineering of Escherichia coli
Authors: Wu Yangbao , Wang Huan , Liu Yang , Zhao Linguo , Pei Jianjun 
Published: August 2022

Abstract
BackgroundC-glycosylated flavonoids are a main type of structural modification and can endow flavonoids with greater stability, bioactivity, and bioavailability. Although some C-glycosylated flavonoids such as the C-glycosylflavones (vitexin, orientin, isovitexin, and isoorientin), the C-glycosyldihydrochalcone (nothofagin), and the C-glycosylchromone (aloesin) have been biosynthesized in vivo or vitro, only a few C-glycosylflavonols have been prepared by these methods.ResultsIn this study, several UDP-glucose biosynthesis pathways and Escherichia coli hosts were screened to reconstruct recombinant strains for producing the novel C-glycosylflavonols kaempferol 8-C-glucoside and quercetin 8-C-glucoside. To increase C-glycosylflavonol production, the timing of flavonol addition was adjusted, and glycerol was added to avoid degradation of C-glycosylflavonols. By using resting cell bioconversion, the highest kaempferol 8-C-glucoside and quercetin 8-C-glucoside production reached 16.6 g/L and 12.5 g/L, respectively. Then, ultrasound-assisted adsorption/desorption was used to prepare C-glycosylflavonols by using macroporous resins. Through screening macroporous resins and optimizing the adsorption/desorption conditions, the highest adsorption capacity and desorption capacity for kaempferol 8-C-glucoside on HPD100 reached 28.56 mg/g and 24.15 mg/g, respectively. Finally, kaempferol 8-C-glucoside (15.4 g) with a yield of 93% and quercetin 8-C-glucoside (11.3 g) with a yield of 91% were obtained from 1 L of fermentation broth.ConclusionsKaempferol 8-C-glucoside and quercetin 8-C-glucoside are novel C-glycosylflavonols, which have not been extracted from plants. This study provides an efficient method for the preparation and biocatalytic synthesis of kaempferol 8-C-glucoside and quercetin 8-C-glucoside by metabolic engineering of Escherichia coli.
Molecular interaction between steroid sulfatases and formylglycine generating enzyme: A computational study with multiple mutations
Authors: Kumari Kanchan , Samal Rashmi Rekha , Subudhi Umakanta 
Published: August 2022

Abstract
Major naturally occurring estrogens are estrone, estradiol and estratriol. Sulfates of naturally occurring estrogen act as reservoirs of potent estrogen and are important at different stages of life among which estrone sulfate is found to be circulating ten times more than estradiol specifically in postmenopausal women. Sulfate esters of estrogen are hydrolyzed by steroid sulfatases (STS) only after it is activated by the enzyme formylglycine generating enzyme (FGE), which is encoded by the gene Sulfatase modifying factor 1 (SUMF1). SUMF1 mutation or dysfunction leads to several pathological consequences. Now identified as a prognostic marker, elevated expression and activity of STS has been observed in several human malignancies and has led to the identification of its inhibitors. Thirteen different sulfatases have been identified in human, all of which are activated by single enzyme FGE. Therefore, we asked the question, does FGE interacts with STS in a unique manner that differs from other group of sulfatases. To address our question, protein-protein molecular docking studies were performed using two docking softwares PyDock and HDOCK with special emphasis on STS and FGE interaction. The present study for the first time reports the basics of molecular interaction/ binding studies of the four major sulfatase groups of enzymes with FGE and reveals the amino acid residues involved for specific sulfatase groups. Interestingly, interaction of STS and FGE was found to be the most stable with highest binding energy and docking score with specific amino acid residues involved. Single or multiple site-directed mutagenesis provides invaluable tool for protein engineering that may be used to inhibit or enhance the function of a protein. To understand the effect of site-specific mutations in STS on its interaction with FGE, we performed mutational studies. Removal of specific amino acid residues significantly affected the interaction of STS with FGE increasing the electrostatic energy and reducing Van der Waal energy drastically. These findings suggest that targeting these specific amino acid residues can inhibit the interaction of FGE with STS leading to reduced activity of STS that in turn may inhibit the production of estradiol thereby reducing cancer progression.
Land-use suitability is not an intrinsic property of a land parcel
Authors: Snelder Ton , Lilburne L , DJ Booker , Whitehead AL , Harris S , ST Larned , Semadeni-Davies A , DR Plew , RW McDowell 
Published: August 2022

Abstract
Agricultural production has economic, environmental, social and cultural consequences beyond farm boundaries, but information about these impacts is not readily available to decision makers. This study applied the Land Use Suitability concept by carrying out an assessment of a region that has the potential for intensification of agricultural production, but where eutrophication of river and estuary receiving environments due to nitrogen enrichment is a significant issue. The assessment evaluated three indicators for each farmable land parcel in the region: productive potential (the inherent productive and economic potential of the parcel), relative contribution (the potential for the parcel to contribute nitrogen to receiving environments compared to other land parcels), and pressure (the load of nitrogen delivered to receiving environments compared to the loads that ensure environmental objectives are achieved). The study indicated that existing data, methods and models can be used to calculate the indicators under different choices for regional land-use intensity and receiving environment objectives. However, the spatial resolution and accuracy that is achievable may preclude using assessment outputs to make land use decisions at small spatial scales such as individual farms. In addition, the study highlighted that land use suitability is not an intrinsic property of a land parcel because it is dependent on choices about land use elsewhere in the landscape and the environmental objectives, and that land use suitability is inherently subjective because of decisions that concern how indicators are combined and weighted.
New horizons in the reproductive biology of Taiwanese pangolin (Manis.p.pentadactyala): Gondal hormonal profile and evidence for delayed implantation
Authors: Arora Bharti , Pei Kurtis Jai-Chyi , Chin Shih-Chien 
Published: August 2022

Abstract

The extant biological reports on pangolins have mainly been established from rescued gravid individuals or a handful of observations done in captivity, thus, generating data discrepancies. The present research characterizes the Taiwanese pangolin's annual seasonal reproductive pattern by measuring immunoreactive estrogens and progestagens in 34 captive females and testosterone in 29 captive males. Our results showed that Taiwanese pangolins are seasonal breeders, with most births (10/13) witnessed during Dec-Jan as field records. Females exhibited spontaneous ovulation and post-partum ovulation. Pregnant females exhibited a higher P4 level for ~ nine months (Jan-Sept) and decreased before parturition (Oct-Dec). The circulating E2 is maintained at the baseline in pregnant females year-round. Contrastingly, in non-pregnant females, P4 is maintained at the baseline apart from slight elevation in January, and E2 demonstrates a sudden hike from November and remains elevated until February, suggesting the onset of ovulation. The serum testosterone concentration in males peaked during October, which is in sync with the female ovulation period. As a result that their major reproductive events, ovulation, mating, and parturition, all transpire from November-March. Evidence also supported that Taiwanese pangolin exhibit the signs of postimplantation (pregnancy) ranging only from 5–6 months (May-October) preceded by facultative delay implantation triggered by lactation. The provided data not only filled in the knowledge gap for this critically endangered species but also can assist in making informed decisions, which can directly affect the successful breeding of this species in captivity.
The effective threshold dose of etanercept biosimilars in patients with methotrexate- resistant rheumatoid arthritis
Authors: Chen Fangfang , Lang Yitian , Geng Shikai , Wang Xiaodong , Lu Liangjing , Ye Shuang , Zhang Le , Li Ting 
Published: August 2022

Abstract
Background: The therapy of rheumatoid arthritis (RA) was advanced by biological agents, yet costly. This study aims to identify the effective threshold dose of etanercept (ENT) biosimilars and evaluate the efficacy, safety and cost-effectiveness in methotrexate (MTX)-resistant RA in real world.Methods: Eligible patients had an inadequate response (DAS28-ESR＞3.2) to initial MTX monotherapy, and subsequently received biosimilar of etanercept. The effective cutoff value of cumulative dose was identified to maintain remission response (DAS28-ESR＜2.6) at month 24 by using restricted cubic splines. Remission rate, LDA rate, glucocorticoid exposure, safety, and cost-effectiveness were compared between the saturated and non-saturated dose groups divided by cutoff dose. Results:78 (14.2%) of 549 enrolled patients were eligible, and 72 patients completed follow-up. The 2-year cumulative cutoff dose that maintained remission response at 24 months was 1975 mg. And the recommended threshold dosing strategy of etanercept biosimilars was twice weekly (BIW) for the first 6 months, every week (QW) for the next six months, and every 2 weeks (Q2W) and every month (QM) for the second year. Greater net changes in DAS28-ESR score were observed in the ENT saturated dose group than in non-saturated dose group (average change 0.569, 95%CI 0.236-0.901, p=0.001). The proportion of patients achieving remission (27.8% vs 72.2%, p<0.001) and LDA (58.3% vs 83.3%, p=0.020) in non-saturated group were both significantly lower than in saturated group at 24 months. The ICER of the saturated group referred to the non-saturated group was 5791.2 $/QALY.Conclusions: In refractory RA patients, the effective cumulative cutoff dose of etanercept biosimilars for sustained remission at 24 months was calculated as 1975 mg, and receiving saturated dose was more effective and cost-effective than with non-saturated dose.
Mutual interaction of the free surface and a depression on the bottom during the propagation of a gravity wave
Authors: EDDOHA Kaoutar , MOUAKKIR Laila , CHAGDALI Mohamed 
Published: August 2022

Abstract
To know the effect of a simultaneous variation of the two influences, we will point out to the observations in a channel at. Experimental reports in a wave channel will be presented in this work. In this work will therefore ensure that the swell interacts with the bottom by validating empirical and theoretical results. Then, simultaneous measurements of the free surface and the evolution of the bottom are presented. The measurements of the free surface are carried out by the technique of fixed probes and the simultaneous monitoring of the evolution of the depression by processing of images synchronized with the measurements of the probes. We have also, developed an experimental high-sensitivity instrumentation, based on data acquisition using LabVIEW software of the resistive probe method to the perform precise measurements of free area. Pressure coefficients, reflection coefficients, transmission coefficients and filling steps as a function of time in a swell channel in the presence of a bottom depression, simultaneous monitoring of the evolution of the depression by processing images synchronized with the measurements of the probes.
Calculating Pharmacokinetic Areas
Authors: Benet Leslie Z. , Patel Anu , Wakuda Hirokazu , Xu Ava 
Published: August 2022

Abstract
Although it is recognized that pharmacokinetic processes follow exponential processes, area under the curve (AUC ) estimations are frequently carried out using linear trapezoidal methods. This is justified based on the fact that most human studies are carried out following oral dosing, and it is believed that a logarithmic trapezoidal method will markedly underpredict the areas for increasing drug concentrations. Here we show that increasing concentrations can be estimated more accurately using a new simple logarithmic method for increasing concentrations. Further, no previous discussion of linear versus logarithmic calculation has been published for area under the moment curve (AUMC ) calculations. Thus, the derivation of a new methodology for calculating area values for logarithmic processes exhibiting increasing values of concentrations and moments is shown. Use of the methodology is presented and compared with the presently utilized linear approach. Pharmacokinetic absorption and elimination processes are primarily assumed to follow an exponential process, so that measurements of concentrations over time exhibit exponential versus linear relationships with time. Therefore, calculations of AUC should be more accurate using logarithmic methods than with linear methods. It is recognized that for decreasing concentrations with time, more accurate calculations of AUC will be estimated using the logarithmic trapezoidal rather than the linear trapezoidal rule. However, it was believed that logarithmic AUC calculations would be more inaccurate for increasing concentrations and moment values. Therefore, there is no generally recommended rule as to how AUCs should be estimated. We show here that a simple logarithmic methodology can be utilized for all increasing values except to the first measurement after time zero. It appears that for concentration-time curves, AUC will be best estimated using logarithmic methods for both increasing and decreasing concentrations. However, it appears that for well-designed sampling schedules, the increased accuracy of using logarithmic trapezoidal methods versus using linear trapezoidal methods is not sufficient to give significant errors in clearance calculations. In contrast, here we show that using linear area calculations for AUMC is probably more accurate than using any combination of linear and logarithmic methods.
3D autonomous warehouse simulation by sequential function chart using CoDeSys V3.5
Authors: Pounraj Manikandan 
Published: August 2022

Abstract
An automated warehouse is a place where materials are stored with an inventory. The materials are tracked for loading and unloading. The process inside the warehouse is executed with less human assistance. For an Automated warehouse, storage and retrieval operations are executed by software tools. This particular system fall in MES – Manufacturing execution system and MOS – Manufacturing operation system. Industrial robots are used in the process of warehouse automation to meet the demand and to reduce the space and costs involved in the warehouse management system. Industrial robots can execute the process in a very fast manner and manage the process in a more precisely. The return on investment (ROI) has a direct impact on the automation process. In this paper, the authors have programmed an industrial controller and used an application programming interface to communicate a 3D warehouse software for loading. Sequential function chart (SFC) language is used to program the PLC as per IEC61131-3