bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hydroxypropyl methylcellulose films reinforced with cellulose micro/nanofibrils: study of physical, optical, surface, barrier and mechanical properties
Authors: Mascarenhas Adriano Reis Prazeres , Scatolino Mário Vanoli , Santos Allan de Amorim dos , Norcino Laís Bruno , Duarte Paulo Junio , Melo Rafael Rodolfo de , Dias Matheus Cordazzo , Faria Caik Elisio Tonelli de , Mendonça Maressa Carvalho , Tonoli Gustavo Henrique Denzin 
Published: April 2022

Abstract
The accumulation of petroleum products causes damage to ecosystems, which can be avoided with cellulose-based products. The influence of different ratios of cellulose micro/nanofibrils (MFC/NFC) on the properties of hydroxypropyl methylcellulose (HPMC) films was evaluated. Films were prepared using proportions of 0, 25, 50, 75 and 100 % (w/w) of MFC/NFC from Pinus sp. in relation to HPMC. Physical, barrier, surface, optical, morphological and mechanical properties were evaluated. Solids content, basis weight and density values increased with higher amount of MFC/NFC and thickness and porosity were reduced. SEM images showed that films with more than 50 % MFC/NFC had a more granular surface, which decreased transparency from 80 to 65 %. Water vapor penetration did not differ between films and degradation in water was reduced from 40 to 5 % with MFC/NFC addition. There were no differences in contact angle and wettability, but all films showed high resistance to fat penetration. Films with MFC/NFC content between 75 and 100 % showed higher values for tensile strength (50 to 65 MPa) and Young’s modulus (6 to 10 MPa) and lower elongation at break (1 to 2 %). The experimental results indicated that films with MFC/NFC content above 50 % have potential to be used as packaging material.
ExcelAutomat 1.4: generation of supporting information
Authors: Laloo Jalal Z. A. , Savoo Nandini , Rhyman Lydia , Ramasami Ponnadurai 
Published: April 2022

Abstract
Quantum chemical computations generate output files with data. The processing of these data generates results which are presented in a target document, such as a manuscript or supporting information (SI). Several tools and techniques can be employed to facilitate the transfer of data which, otherwise, can be time-consuming with a large number of files. However, depending on the user’s technical knowledge or expertise with the software, additional time has to be invested to set up the software or use the tools. In addition, to the best of the authors’ knowledge, the tools currently available do not provide an option to transfer the data from the output files directly to the target document without the use of custom scripts. The ExcelAutomat tool (Laloo et al., J. Comput. Aided Mol. Des. 2017, 31, 667 and Laloo et al., J. Comp. Chem. 2019, 40, 3) is spreadsheet-based and was developed in-house to facilitate the steps involved in the processing of computational files. The tool was adapted to facilitate the generation of SI in an update of ExcelAutomat 1.4. A graphical user interface was designed where the options for the generation of SI can be defined. ExcelAutomat 1.4 is compatible with Microsoft Excel and the open-source LibreOffice Calc. The extensible tool supports various software packages and parameters by interfacing with the cclib library and through built-in codes. The tool provides a method to transfer data from output files directly to a Microsoft Word or LibreOffice Writer document and can reduce the number of steps, tools or technical knowledge needed to generate SI, especially for users who are familiar with Microsoft Excel or LibreOffice Calc.
A novel theranostic probe [111In]In-DO3A-NHS-nimotuzumab in glioma xenograft
Authors: Tang Yu , Liao Zhonghui , Li Feize , Liu Weihao , Gao Jing , Li Yuhao , Hu Yingjiang , Cai Huawei , Ma Huan , Yang Yuanyou , Yang Jijun , Liao Jiali , Liu Ning 
Published: April 2022

Abstract
Indium-111 (111In) has an appropriate half-life (T
1/2 = 67 h) and energy characteristics for cancer diagnosis via γ-ray imaging and cancer therapy with Auger electrons. The aim of our study is to evaluate the potential of [111In]In-DO3A-NHS-nimotuzumab as a theranostic agent for radioimmunoimaging (RII) and radioimmunotherapy (RIT) against human glioma xenografts in mice. We explored the chelators DO3A-NHS and DOTA-p-SCN-Bz to optimize 111In radiolabeling efficiency of nimotuzumab. The radiopharmaceuticals were purified by PD-10 mini-column and their in vitro stabilities were assessed. We investigated the biodistribution of [111In]In-DO3A-NHS-nimotuzumab as it had relatively superior labeling efficiency and stability in vitro. We conducted SPECT imaging on mice bearing glioma (U87MG) xenografts, which were injected with ∼3.7 MBq of [111In]In-DO3A-NHS-nimotuzumab. The in vivo radiotherapeutic effects of [111In]In-DO3A-NHS-nimotuzumab was analyzed via injecting a single 37 MBq dose, 2 × 18 MBq doses, or 2 × 37 MBq doses into mice bearing U87MG xenografts. The control groups were administered either 30 μg nimotuzumab or saline. The radiochemical yields of [111In]In-DO3A-NHS-nimotuzumab and [111In]In-DOTA-p-SCN-Bz-nimotuzumab were > 85% and > 75%, respectively. [111In]In-DO3A-NHS-nimotuzumab had > 95% radiochemical purity and was more stable in vitro than [111In]In-DOTA-p-SCN-Bz-nimotuzumab. Biodistribution study demonstrated that [111In]In-DO3A-NHS-nimotuzumab was highly stable in vivo. SPECT imaging disclosed that [111In]In-DO3A-NHS-nimotuzumab had excellent targeted tumor uptake and retained in tumors for 24 and 72 h. All [111In]In-DO3A-NHS-nimotuzumab treatments substantially inhibited tumor growth over the controls. The 2 × 37 MBq treatment was particularly efficacious, and presented with survival time prolonged by ≤66 days. In contrast, the survival time of the control group was only 30 days. In our study, we developed an optimized synthesis protocol for radiopharmaceutical 111In-DO3A-NHS-nimotuzumab and demonstrated that it is a promising theranostic agent. It could be highly efficacious in RII and RIT against EGFR-expressing glioma.
MEDIA RETORIKA DAKWAH PADA ERA MILENIAL
Authors: Trilaksono Bobby H. , Prasetyawan Wahyu , Amirudin Amirudin , Rizky Kiky 
Published: April 2022

Media retorika menjadi sebuah seni yang dapat membantu tercapainya proses komunikasi dan mempengaruhi orang lain untuk menerima isi pesan yang disampaikan. Retorika dakwah merupakan poin penting yang dibutuhkan dalam menyampaikan sebuah isi pesan dakwah yang diberikan kepada manusia. Penerapan retorika dakwah dapat membantu tercapainya tujuan dakwah yang diinginkan. Setiap orang akan memiliki kesempatan yang sama untuk bisa menyampaikan dakwah di era milenial seperti saat ini. Adanya penerapan seni berbicara yang mampu diterima dengan mudah oleh para khalayak. Di era milenial masyarakat telah mengalami perubahan pada pola hidup di mana segala sesuatunya didampingi dengan penggunaan teknologi digital. Manusia serasa tidak bisa hidup tanpa adanya teknologi digital yang kini dapat membantu terpenuhinya kebutuhan yang dimiliki. Tentunya, dakwah akan bisa dilakukan dengan baik dan mampu mempersuasi penerima pesan saat dilakukan dengan memanfaatkan teknologi digital. Kini dakwah dapat dilakukan dan disebarkan melalui beragam media sosial seperti WA, Facebook, internet, Instagram, Youtube, Twitter, dan media lainnya.Kata Kunci: media retorika, dakwah, era milenial.
FASE TRANSFORMASI IDEOLOGI PERTUNJUKAN TEATER KANVAS
Authors: Makki Nur Kholis , Qoyim Ibnu 
Published: April 2022

Penelitian ini berbentuk penelitian kualitatif dengan menggunakan pendekatan etnografi yang bertujuan untuk melihat bagaimana proses transformasi ideologi pertunjukan pada salah satu kelompok Teater di Jakarta, yaitu Teater Kanvas. Dalam penelitian ini peneliti menggunakan data wawancara, naskah pertunjukan dan beberapa kliping pemberitaan seputar pertunjukan, ataupun pemberitaan eksklusif tentang Teater Kanvas yang diambil pada Oktober 2019 hingga Juli 2020. Setelah memperoleh data dari naskah, dokumentasi, kliping berita dan wawancara, langkah selanjutnya adalah mengklasifikasikan data sesuai dengan permasalahan yang diteliti, kemudian data tersebut disusun, dianalisis dan dikelompokkan. Hasil penelitian ini adalah proses transformasi Ideologi pertunjukan Teater Kanvas yang terdiri dari tiga fase, yaitu; fase ideologi pertunjukan awal, fase transisi ideologi pertunjukan dan fase ideologi baru pertunjukan Teater Kanvas.Kata Kunci: teater, transformasi, pertunjukan, ideologi
IMPLEMENTASI TEORI KOMUNIKASI DALAM PENGGUNAAN TRADISI LISAN LAWAS PAMUJI PADA MASYARAKAT SUKU SUMBAWA
Authors: Natasari Nofia , Marhandra Roy 
Published: April 2022

Tradisi Lisan Lawas Pamuji masih melekat dalam kehidupan sosial masyarakat Sumbawa. Pesan-pesan yang disampaikan sebagai motif menggugah kesadaran masyarakat untuk meningkatkan keimanan. Keberlangsungan penggunaan Lawas Pamuji di tengah-tengah masyarakat di ekspresikan oleh para pegiat seni dan para pendakwah dalam berbagai metode, dan produk karya seni tradisi. Lawas Pamuji yang hingga hari ini masih dapat kita temukan di dalam kehidupan masyarakat, tentu menjadi pertanyaan di dalam benak kita bagaimana komunikasi yang berlangsung di dalam masyarakat Sumbawa sehingga proses penyaluran, pewarisan kepada generasi selanjutnya. Untuk menganalisis hal tersebut, peneliti menggunakan teori komunikasi model Harold Laswell. Sementara untuk memahami dan memudahkan peneliti dalam mengurai apa saja komponen komunikasi dalam Lawas Pamuji, dengan menggunakan teori tradisi lisan Albert Lord. Hasil yang ditemukan di dalam penelitian tersebut adalah, bahwa proses komunikasi yang berlangsung di dalam penggunaan Lawas Pamuji pada masyarakat Sumbawa telah memberikan dampak kepada perubahan sikap dan bertambahnya ilmu pengetahuan. Hal tersebut dapat ditunjukkan dalam operasional komponen komunikasi Lawas Pamuji dalam kehidupan masyarakat suku Sumbawa.Kata Kunci: komunikasi, lawas pamuji, suku sumbawa
KOMUNIKASI, TEKNOLOGI INFORMASI DAN KETENAGA KERJAAN KAJIAN PERKEMBANGAN INKLUSI TEKNOLOGI DIGITAL DAN PENGANGGURAN DI INDONESIA
Authors: Soniansih Seni , Kusmiati Yopi , Humeira Bintan 
Published: April 2022

Inovasi teknologi dikhawatirkan menyebabkan pengangguran massal. Namun Inovasi teknologi juga dibutuhkan dalam mendorong pertumbuhan ekonomi. Tujuan makalah ini adalah memahami dan meramalkan dampak inovasi teknologi terhadap tenaga kerja di Indonesia dengan pendekatan model John Hick yang di estimasi menggunakan model Threshold Autoregressive (TAR). Penelitian ini berusaha mengkontruksi dan memetakan dampak inovasi teknologi pada ketenaga-kerjaan serta mencari solusi mengatasi dilema inovasi teknologi dan ketenaga kerjaan dan mengkombinasi dengan metode kuantitatif content analysis.Kami menemukan bahwa inovasi teknologi memiliki pengaruh terhadap ketenagakerjaan,potensi pembukaan peluang kerja baru sebagai dampak positif inovasi teknologi sebagai kompensasi penekanan kesempatan kerja akibat inovasi teknologi.Kata Kunci : Indonesia, Pengangguran, Inovasi, Teknologi.
Ultra-processed food intake and eating disorders: Cross-sectional associations among French adults
Authors: Figueiredo Natasha , Kose Junko , Srour Bernard , Julia Chantal , Kesse-Guyot Emmanuelle , Péneau Sandrine , Allès Benjamin , Paz Graniel Indira , Chazelas Eloi , Deschasaux-Tanguy Mélanie , Debras Charlotte , Hercberg Serge , Galan Pilar , Monteiro Carlos A. , Touvier Mathilde , Andreeva Valentina A. 
Published: April 2022

Abstract

Background and aims
Data regarding the association between ultra-processed food (UPF) consumption and eating disorders (ED) are scarce. Our aim was to investigate whether UPF intake was associated with different ED types in a large population-based study.

Methods
43,993 participants (mean age = 51.0 years; 76.1% women) of the French NutriNet-Santé web-cohort who were screened for ED in 2014 via the Sick-Control-One stone-Fat-Food (SCOFF) questionnaire, were included in the analysis. The clinical algorithm Expali
TM tool was used to identify four ED types: restrictive, bulimic, binge eating, and other (not otherwise specified). Mean dietary intake was evaluated from at least 2 self-administered 24-h dietary records (2013–2015); categorization of food as ultra-processed or not relied on the NOVA classification. The associations between UPF intake (as percent and reflecting mean daily UPF quantity (g/d) within the dietary intake, %UPF) and ED types were evaluated using polytomous logistic regression models.

Results
5,967 participants (13.6%) were categorized as likely ED (restrictive n = 444; bulimic n = 1,575; binge eating n = 3,124; other ED n = 824). The fully-adjusted analyses revealed a positive association between UPF intake and bulimic, binge eating, and other ED: ED risk (odds ratio, OR) for an absolute 10-percentage point incremental increase in %UPF intake were 1.08 (1.01–1.14; P = 0.02), 1.21 (1.16–1.26; P < 0.0001), and 1.11 (1.02–1.20; P = 0.02), respectively. No significant association was detected for restrictive ED.

Discussion and Conclusion
This study revealed an association of UPF intake with different ED types among French adults. Future research is needed to elucidate the direction of the observed associations.
Lithospheric Structure underneath the Archean Tanzania Craton and Adjacent Regions from a Joint Inversion of Receiver Functions and Rayleigh-Wave Phase Velocity Dispersion
Authors: Wang Tuo , Gao Stephen S. , Yang Qiuyue , Chen Ling , Liu Kelly H. 
Published: April 2022

Abstract
Lithospheric structure beneath the Archean Tanzania craton and adjacent regions, including segments of the East African rift system (EARS) and the Proterozoic–early Paleozoic orogenic belts between the EARS and the craton, is imaged by a joint inversion of receiver functions and Rayleigh wave dispersion measurements derived from ambient seismic noise for shorter periods and teleseismic data for longer periods. Our resulting crustal thickness, crustal VP/VS measurements and 3D shear-wave velocity model for the upper 120 km show a clear spatial correspondence with major surficial geological features. The new results suggest the presence of a mafic layer in the bottom of the crust of the entire Archean craton, which is previously only identified beneath the southern portion of the craton. High crustal VP/VS values measured in the Rungwe Volcanic Province and most areas of the Kenya and Tanganyika rift segments can be attributed to a combined result of basaltic sediments atop the crust, magmatic intrusion, and crustal partial melting. The Kivu Volcanic Province and parts of the Kenya rift segment are characterized by localized lower-than-normal crustal VP/VS values and shear velocities in the lower crust and uppermost mantle, which, given the presence of large volume of CO2 from surficial observations, can be best interpreted by CO2-filled fractures or conduits. Lower-than-normal shear velocities in the uppermost mantle are revealed beneath almost the entire study region with the lowest values found in all the three volcanic provinces. The low velocities are indicative of an underplated layer formed by mantle-derived magmatic materials trapped below the Moho. The relatively low velocities beneath the volcanic provinces might be caused by a higher degree of partial melting in the uppermost mantle.
Bilastine - Novel anti histamine drug for allergic rhinitis
Authors: Trailokya Abhijit , Roy Soumen 
Published: April 2022

The immune system is a fundamental part of human protection against infection and disease.The immune system can occasionally lead to unfavourable reactions in the host which are known as hypersensitivity reactions. The exaggerated immune reactivity (hypersensitivity) to certain environmental substances (allergens) like airborne pollens, dust, mites, pet dander, and reactions to certain foods that normally have little effect on most people is known as allergy. The incidence of allergic disease like allergic rhinitis (AR), food borne allergy, asthma and anaphylactic reactions are prevalent in 25% of populations predominately in adolescents and adults in industrialised countries. Bilastine is a novel second-generation non-sedative, highly selective histamine H1 receptor antagonist that suppresses some allergic inflammatory processes that inhibits the release of histamine from mast cells and is approved in the treatment allergic rhinitis, urticaria and pruritus associated with skin diseases. This review covers the safety, efficacy and pharmacological aspects of Bilastine as an important product for treatment of allergic rhinitis.
Successful management of cytokine storm induced acute respiratory distress syndrome secondary to H1N1 influenza with itolizumab: A case series
Authors: Siddavaram Deepak 
Published: April 2022

Critically ill patients often have a dysregulated immune response to the underlying insult leading to varied clinical features and end-organ dysfunction. One of the dysregulated immune responses termed ‘cytokine storm (CS)’ secondary to SARS-COV-2 during the recent COVID-19 pandemic was responsible for unacceptably high morbidity and mortality across the world. Cytokine storm is not unique to just COVID-19 but can also occur due to certain other viruses like H1N1 influenza. This phenomenon accelerated not only our understanding of the underlying pathophysiology and the role of the immune system in critically ill patients but also strengthened the concept of the possible need for an immunomodulator incorporated with standard therapy for treating Acute Respiratory Distress Syndrome(ARDS). Itolizumab, a reformulated anti-CD-6 humanized monoclonal antibody, downregulates the synthesis of proinflammatory cytokines leading to reduced interferon-γ (IFNγ), interleukin (IL-6), and tumour necrosis factor-α (TNFα) levels, along with reduced T-cell infiltration at the inflammatory site. Its usage in the management of CS in non-COVID 19 ARDS seems to be an appealing therapeutic approach given its mechanism of action. The current cases highlight an underlying possible hyperimmune response secondary to H1N1 in two patients who were successfully managed using Itolizumab along with standard treatment of ARDS.
O biodiesel na matriz energética brasileira: da sua inserção aos dias atuais
Authors: Nascimento Tassio Lessa do , Maciel Maria Aparecida Medeiros , Gurgel Helen Elisia De Souza , Rios Maria Alexsandra De Sousa , Bertini Luciana Medeiros 
Published: April 2022

<p>Em uma conjuntura de preocupações crescentes com o aumento dos problemas ambientais, os biocombustíveis, em especial o Biodiesel, representam uma ferramenta significativa para contenção da emissão de poluentes e, ainda, contribuem para o empreendedorismo da economia regional. Nesse sentido, o presente artigo buscou investigar os mais variados aspectos que envolvem a produção e a utilização desse tipo de combustível, tais como: principais matérias-primas, políticas de regulamentação, as formas de sínteses e suas produções, bem como estímulos governamentais e questões socioeconômicas e ambientais. Dessa forma, foram utilizadas pesquisas documentais e revisões bibliográficas sobre biodiesel, desde sua origem, em 1937, até os dias atuais. Nesse cenário, concluiu-se que, mundialmente, o combustível oleaginoso representa uma alternativa promissora para o balanceamento entre desenvolvimento sustentável e redução de gases poluentes, além de fomentar a produção regional e políticas governamentais, por ser tecnologia de inserção ecocompatível. </p>
The Effectiveness of Prevention and Relationship Enhancement Program on the Quality of Life and Marital Commitment in Married Women
Authors: Habibi Narges , Fathi Elham , Hatami Varzaneh Abolfazl , Aghajani Seifollah 
Published: April 2022

Background and Purpose: There are several ways to enhance marriage. Prevention and Relationship Enhancement Program (PREP) are among the methods of educating relationships. Relationship education programs have made a significant contribution to the growth and development of millions of couples. This study aimed to investigate the effectiveness of the Prevention and Relationship Enhancement Program (PREP) on quality of life and marital commitment in married women.
Materials and Methods: This quasi-experimental research was conducted in a pretest-posttest control group design with 15 participants in the experimental group and 15 participants in the control group. Marital Commitment Questionnaire (DCI), and World Health Organization Quality of Life Questionnaire (WHOQOL) were completed as research instruments by the participants. The full version of PREP.8 was presented to the group of 15 participants over a weekend for a total of 12 hours, with each segment lasting for two hours. The Multivariate Analysis of Covariance (MANCOVA) as well as the Univariate Analysis of Covariance (ANCOVA) tests were used. Hedge´s g effect size (ES) was also calculated to determine the magnitude of pairwise comparisons.
Results: The findings indicated that there was a significant difference between the experimental and control groups in terms of quality of life (Social Relations: Exp:12.27±1.28, Cont:11.13±1.64, P≤0.03; Environment, Exp:30.73±3.06, Cont:28.67±3.27, P≤0.02) and marital commitment (Structural Commitment: Exp: 76.40±5.08, Cont: 70.53±3.42; P≤0.02).
Conclusion: We concluded that utilizing PREP can successfully help Iranian couples in their relationships providing them with more knowledge and skills.
Heavy Metals Contamination in the Surface Sediments of Talar River, North of Iran
Authors: Vakilzadeh Yaser , Shabani Gorji Kazem , Ghalamghash Jalil , Noura Mohammad Reza 
Published: April 2022

Background and Purpose: The contamination by potentially toxic element (PTE) is a common environmental issue in worldwide rivers. The present study examined PTEs concentration in sediments of Talar River which is one of the main rivers in the Sothern Caspian Basin.
Materials and Methods: The sediment samples (n= 44) were collected from top 0–5 cm of surface sediment in the main channel and floodplain of Talar River using a Van-Veen grab sampler. The concentrations of trace elements were determined by inductively coupled plasma mass spectrometry (ICP-MS). Principal component analysis (PCA) was used to evaluate possible relationships between the observed variables and source identification. Enrichment factor (EF) was also applied to determine the integrated effects of different elements and evaluate the sediment quality.
Results: The average concentration of all elements except Mo were found to be higher than the concentration of elements in upper continental crust (UCC). The result of enrichment factor (EF) indicated that most elements were unpolluted and showed minimal to moderate contamination level. Multivariate statistical analysis indicated Pb, Cu, V, Zn, Cd, Co and Ni typically have anthropogenic sources. Whereas Mn, Sb, Sc, Mo and as showed geogenic source.
Conclusion:It was concluded that sediments in Talar River was then experiencing slightly polluted status originated from local anthropogenic sources in the basin which might potentially pose detrimental effects on both ecological and health conditions in the basin.