bluuebunny/crossref_metadata_2025_split huggingface dataset:
Iatrogenic injury of the urinary tract during salvage procedures for pelvic sepsis: Experience of a national referral centre
Authors: Joosten Johanna J. , Sharabiany Sarah , Musters Gijsbert D. , Beerlage Harrie P. , Tanis Pieter J. , Bemelman Wilhelmus A. , Hompes Roel 
Published: June 2022

AbstractAimThis study aimed to determine the incidence, consequences and outcomes of iatrogenic urinary tract injury (IUI) during salvage surgery for pelvic sepsis.MethodPatients who underwent salvage surgery for pelvic sepsis after prior low anterior resection or Hartmann's procedure for rectal cancer were prospectively maintained in a database between 2010 and 2020 and reviewed retrospectively. The primary endpoint was the incidence of IUI. Secondary endpoints were timing of diagnosis (intra‐ vs. postoperative), reinterventions related to the IUI and healing of IUI.ResultsIn total 126 consecutive patients were included, and IUI occurred in 13 patients (10%). A ureteric injury occurred in eight patients, bladder injury in four patients and a urethral injury in one patient. All patients with an IUI had radiotherapy as neoadjuvant treatment. The IUI was diagnosed postoperatively in 63% (n = 8/13) with a median duration between surgery and diagnosis of the IUI of 10 days (IQR: 6–15). The median number of reinterventions was five (range 1–31) in the group with a postoperative diagnosis and one (range 0–1) in the group with an intraoperative diagnosis. Four patients required a surgical reintervention, all concerning injuries diagnosed postoperatively. At the end of follow‐up, 85% of patients (n = 11/13) had a healed IUI.ConclusionIatrogenic urinary tract injury is not uncommon in salvage procedures for pelvic sepsis, even in an experienced tertiary referral centre. Most injuries were diagnosed postoperatively which affects the severity of these complications, emphasising the need to improve intraoperative diagnostic modalities.
Fatigue behaviors of a titanium alloy in the VHCF regime based on a vibration‐based bending fatigue test
Authors: Xu Wei , Chen Xin , Gao Zhiyuan , Li Ying , He Yuhuai , Tao Chunhu 
Published: June 2022

AbstractA vibration‐based bending fatigue test based on electrodynamic shaker is conducted in order to study the high cycle and very high cycle fatigue (VHCF) behaviors of a titanium alloy TC17 with a sort of novel specimens. After obtaining a full S‐N curve covering the lifetime up to 109 cycles, several fatigue crack initiation and failure process modes are revealed based on the observation of the fracture surfaces. Especially, the statistical distribution characteristics of the fatigue lifetime and some relevant factors are discussed. The results indicate that the obtained S‐N curve does not exhibit a plateau region in the VHCF regime. And the present crack initiation mechanism involves the facets formed by the primary α‐phase cleavage and the development of microcracks. Moreover, the scatter of the fatigue lifetime can be obviously influenced by the resonance frequency range of the specimens.
Effect of oxygen and fluorine plasma surface treatment of silicon‐incorporated diamond‐like carbon coatings on cellular responses of mouse fibroblasts
Authors: Riley Parand R. , Yang Kai‐Hung , Liu Yizhong , Skoog Shelby A. , Narayan Jagdish , Narayan Roger J. 
Published: June 2022

AbstractThe surface chemistry of silicon‐incorporated diamond‐like carbon (Si‐DLC) was tailored utilizing oxygen and fluorine plasma treatments. Successful anchoring of oxygen and fluorine functional groups to the surface of Si‐DLC was verified using X‐ray photoelectron spectroscopy. The impact of surface modification of Si‐DLC on hydrophobicity was correlated with the viability of L929 mouse fibroblasts. The confocal microscopy and viability results indicated that oxygen‐treated Si‐DLC showed increased cell viability compared to untreated Si‐DLC and fluorine‐treated Si‐DLC samples 5 days after seeding. The increased cell viability was correlated with the conversion of the hydrophobic surface of Si‐DLC into a hydrophilic surface by oxygen plasma treatment.
Erythrocyte sedimentation rate measurements using MIX‐RATE® X20 and VISION A automated analyzers: Method validation and comparison study
Authors: Prompetchara Eakachai , Nowaratsopon Sunudda , Wongkamchai Suppakorn , Srieakpanit Jittra , Ketloy Chutitorn 
Published: June 2022

AbstractBackgroundThe Westergren method for erythrocyte sedimentation rate (ESR) measurement has a few drawbacks such as being a time‐consuming process, poses a risk of biohazard exposure and requires high sample volume. Recent alternative methods and analyzers were developed to overcome those limitations. In this study, we validated two automated ESR analyzers, MIX‐RATE® X20 and VISION A, and assessed their analytical performance against the Westergren method.MethodsThe analyzers were validated for inter‐run and intra‐run precision. Hemolysis interference and sensitivity to fibrinogen were also analysed. Analytical performance was performed using 177 patient samples spanning low (<40 mm/h), medium (40–80 mm/h), and high (>80 mm/h) ESR ranges. Method agreement and bias against the Westergren method were calculated.ResultsThe highest intra‐run imprecision was seen in the low ESR range for both analyzers. They showed very high agreement with the Westergren method assessed by Spearmen rank correlation coefficient analysis, r = 1.000, p < .0001 for both analyzers. Bland–Altman analysis yielded overall insignificant mean biases for all comparisons. However, systematic positive and negative bias were observed at medium and high ESR levels analysed by MIX‐RATE® X20 while negative bias was evidenced in the high ESR level measured by VISION A.ConclusionsOverall, results from both automated ESR analyzers showed comparable analytical performance with the Westergren method especially for low ESR levels. However, both positive and negative systematic bias were documented in the high levels. Thus, for clinical use, it must be assessed whether these biases could affect the cut‐off for significant clinical values.
Photoluminescence of rare‐earth/transition metal‐doped transparent/translucent polycrystalline Al2O3 ceramics: A review
Authors: Klement Róbert , Drdlíková Katarína , Drdlík Daniel , Maca Karel 
Published: June 2022

AbstractTransparent alumina doped with rare‐earth or transition metal oxides represents a group of materials suitable for optical applications. Because of the birefringence of alumina, their preparation is demanding on the quality of starting materials, their advanced shaping, and pressure‐assisted sintering. Spark plasma sintering and hot isostatic pressing have proven at achieving pore‐free fine microstructures exhibiting high in‐line transmission and a sufficient intensity of emitted light. The present review aims to summarize the results published on this topic, to compare them and on this base to propose other possible and/or appropriate approaches to future.
Comparison of mental health outcomes of augmenting medications for patients with posttraumatic stress disorder: A national veterans affairs study
Authors: Ranney Rachel , Maguen Shira , Woods Anne , Seal Karen H. , Neylan Thomas C. , Bernardy Nancy , Wiechers Ilse , Ryder Annie , Cohen Beth E. 
Published: June 2022

AbstractRationalePosttraumatic stress disorder (PTSD) is highly prevalent among veterans. Many veterans with PTSD respond well to serotonin reuptake inhibitors (SRIs). Nonresponders may be prescribed augmenting medications, which are not as well‐studied in PTSD.Aims and ObjectivesWe used Veterans Health Administration electronic records to compare mental health outcomes (PTSD symptoms and rates of mental health hospitalizations and psychiatric emergency room visits) in patients with PTSD who were prescribed four different groups of augmenting medications (atypical antipsychotics, mirtazapine, prazosin or tricyclic antidepressants) in addition to SRIs—from the year before to the year after the start of the augmenting medication.MethodWe included data from 169,982 patients with a diagnosis of PTSD (excluding patients with comorbid bipolar or psychotic disorders) seen in Veterans Affairs care from 2007 to 2015 who were taking an SRI and filled a new prescription for one of the four augmenting medications for at least 60 days.ResultsPatients evidenced minimal (<2%) reduction in PTSD symptoms and a larger reduction in psychiatric hospitalizations and psychiatric emergency room visits after receiving augmenting medications; this effect was largely similar across the four medication groups. Initiating augmenting medications was preceded by increases in PTSD symptoms, psychiatric hospitalizations and psychiatric emergency room visits. After initiating an augmenting medication, PTSD symptoms/hospitalizations/emergency room visits returned to baseline levels (before the start of the augmenting medication), but generally did not improve beyond baseline.ConclusionImportantly, these effects could be explained by regression to the mean, additional interventions or confounding. These findings should be further explored with placebo controlled randomized clinical trials.
Telomere is shortened in patients with irritable bowel syndrome in the Chinese population
Authors: Zhang Yuan , Fu Fengyihuan , Zhang Liangjie , Zhang Weihong , Chen Lin , Zhang Yong , Chen Wenji , Du Yanlei , Chen Shuzhen , Zhan Qi , Feng Zhiqiang , Xu Haoming , Nie Yuqiang 
Published: June 2022

AbstractBackground and AimTelomere shortening is an accepted indicator of aging. Many studies have investigated an association between leukocyte telomere length (LTL) and psychiatric disorders. Mental or psychological factors could be an important cause of irritable bowel syndrome (IBS). However, there are currently few research evaluating correlations between LTL and IBS.MethodsWe examined associations between LTL and IBS using quantitative polymerase chain reaction in independent cohorts, including 205 patients with IBS and 189 healthy controls. Furthermore, we examined whether mental or psychological factors, types of IBS, duration of IBS and antidepressants had an association with LTL in patients with IBS.ResultsAmong total samples, patients with IBS presented shorter LTL when compared to healthy controls (P < 0.0001). Moreover, in subgroup analyses of patients with IBS, not only the LTL in patients with IBS caused by mental or psychological factors was shorter (P < 0.0001), but also in patients with IBS that were caused by other factors (P = 0.0082). Furthermore, LTL in patients with IBS who had taken antidepressants for more than 1 month was longer than that in patients with IBS who did not take antidepressants or took for less than 1 month (P < 0.0001).ConclusionsThis is the first study to describe the relationship between LTL and IBS. This study showed significantly shorter telomeres in patients with IBS. Our findings suggest that LTL may hold the potential to serve as a predictor of IBS diagnosis.
Posttraumatic growth and postpartum depression in women after childbirth: The moderating role of postpartum negative life events
Authors: Jiang Cuiting , Zhuang Youqing , Li Zhiyun , Lin Wenxuan , Huang Pei , Feng Yongshen , Liu Shaofei , Zhang Lifeng 
Published: June 2022

AbstractAimThis study aimed to investigate the implications of postpartum negative life events on postpartum depression and posttraumatic growth in women after childbirth.MethodsA sample of 280 postpartum women at a level III hospital in China provided data on postpartum depression, negative life events, and posttraumatic growth with a cross‐sectional design.ResultsThe scores of both postpartum depression and negative life events exhibited a quadratic correlation with posttraumatic growth in women after childbirth, and negative life events significantly moderated the associations between depression and overall posttraumatic growth and its three dimensions: personal strength, spirit change, and relating to others.ConclusionsWomen can experience positive psychological growth after childbirth, and this study provides new evidence of an interaction between postpartum depression and negative life events in the prediction of psychological growth, highlighting the moderating role of negative life events. This study could help direct mental health professionals to target interventions that provide more psychological support to reduce the impact of depression and negative life events, which will be conducive to improving women's psychological growth.
Outpatient hysteroscopy is effective for uterine cavity evaluation following failed office‐based endometrial biopsy
Authors: Nguyen Dong B. , Gerber Victoria E. M. , Suen Michael W. H. , Flaxman Teresa E. , Singh Sukhbir S. 
Published: June 2022

AbstractBackgroundFailure to obtain an office‐based endometrial biopsy for abnormal uterine bleeding is not uncommon. Although operating room‐based procedures are traditionally considered the gold standard assessment tool in these circumstances, outpatient hysteroscopy is a less invasive, more cost‐effective, and safer alternative. However, there is no contemporary Canadian literature on the effectiveness of an outpatient approach for this specific population.ObjectiveWe aim to evaluate the effectiveness and outcomes of outpatient hysteroscopy for uterine cavity evaluation for patients who have failed an in‐office endometrial biopsy attempt.MethodsWe conducted a retrospective cohort study of all patients referred to an academic outpatient hysteroscopy unit between January 2015 and January 2018, who underwent an outpatient hysteroscopy following failed endometrial biopsy. Data were collected from electronic medical records.ResultsOf the 407 consecutive patients who underwent an outpatient hysteroscopic procedure, 68 met inclusion criteria. Postmenopausal bleeding was the most common indication for initial biopsy, and most failures were attributed to cervical stenosis. Outpatient hysteroscopies were successfully completed in 96% of cases (n = 65/68). Failure resulted from either anxiety and discomfort (n = 2), or severe intrauterine adhesions (n = 1). Overall, 10% of patients subsequently required an operating room‐based hysteroscopy, either to complete a myomectomy or polypectomy, or to allow general anesthesia. Outpatient hysteroscopy identified endometrial hyperplasia and cancer in 4.5% and 3% of patients, respectively.ConclusionOutpatient hysteroscopy following unsuccessful office endometrial biopsy attempts appears to be a feasible, safe, and cost‐effective investigation strategy that may prevent the need for an operating room‐based procedure in 90% of cases.
Integrated proteomics, phosphoproteomics and metabolomics analyses reveal similarities among giant cell granulomas of the jaws with different genetic mutations
Authors: Vitório Jéssica Gardone , Duarte‐Andrade Filipe Fideles , Pereira Thais dos Santos Fontes , Melo‐Braga Marcella Nunes , Canuto Gisele André Baptista , Macedo Adriana Nori de , Lebron Yuri Abner Rocha , Moreira Victor Rezende , Felicori Liza Figueiredo , Lange Liséte Celina , Santos Lucilaine Valéria de Souza , Larsen Martin R. , Gomes Carolina Cavalieri , Gomez Ricardo Santiago 
Published: June 2022

AbstractBackgroundGiant cell granuloma of the jaws are benign osteolytic lesions of the jaws. These lesions are genetically characterized by mutually exclusive somatic mutations at TRPV4, KRAS, and FGFR1, and a fourth molecular subgroup which is wild‐type for the three mutations. Irrespective of the molecular background, giant cell granulomas show MAPK/ERK activation. However, it remains unclear if these mutations lead to differences in their molecular signaling in giant cell granulomas.MethodsMetabolomics, proteomics, and phosphoproteomics analyses were carried out in formalin‐fixed paraffin‐embedded samples of giant cell granuloma of the jaws. The study cohort consisted of five lesions harboring mutations in FGFR1, six in KRAS, five in TRPV4, and five that were wild‐type for these mutations.ResultsLesions harboring KRAS or FGFR1 mutations showed overall similar proteomics and metabolomics profiles. In all four groups, metabolic pathways showed similarity in apoptosis, cell signaling, gene expression, cell differentiation, and erythrocyte activity. Lesions harboring TRPV4 mutations showed a greater number of enriched pathways related to tissue architecture. On the other hand, the wild‐type group presented increased number of enriched pathways related to protein metabolism compared to the other groups.ConclusionDespite some minor differences, our results revealed an overall similar molecular profile among the groups with different mutational profile at the metabolic, proteic, and phosphopeptidic levels.
Urban‐rural differences in tobacco product availability in food retailers, United States, 2017
Authors: Reimold Alexandria E. , Kong Amanda Y. , Delamater Paul L. , Baggett Christopher D. , Golden Shelley D. 
Published: June 2022

AbstractPurposeTobacco use prevalence is higher in rural compared to urban settings, possibly due to differences in tobacco availability, including the option to purchase food and other essential items in stores that do not sell tobacco (tobacco‐free food retailers). The goal of this research is to determine whether tobacco‐free food retailer availability varies by urbanicity/rurality.MethodsUsing the 2017 National Establishment Time‐Series database, we identified food retailers across all census tracts containing food retailers in the United States (n = 66,053). We used multivariable logistic and linear regression models to test whether tobacco‐free food retailer availability varied across 4‐levels of census tract urbanicity/rurality (urban, suburban, large town, and small town/rural) for 2 outcomes: (1) the presence of at least 1 tobacco‐free food retailer and (2) the percent of all food retailers that were tobacco‐free.FindingsCompared to urban core census tracts, suburban census tracts had a lower odds (aOR = 0.77, 95% CI = 0.73, 0.81) of having at least 1 tobacco‐free food retailer, while small town/rural census tracts had greater odds (aOR = 1.23, 95% CI = 1.15, 1.32). Suburban census tracts (B = –2.29, P < .001) and large town census tracts (B = –1.90, P < .001) also had a lower percentage of tobacco‐free food retailers compared to urban census tracts.ConclusionsCompared to urban cores, tobacco‐free food retailers were less prevalent in suburban and large town areas, though similarly or slightly more available in rural areas. Future research should assess whether these differences depend on varying store types.
The orexin story, sleep and sleep disturbances
Authors: Pizza Fabio , Barateau Lucie , Dauvilliers Yves , Plazzi Giuseppe 
Published: June 2022

SummaryThe orexins, also known as hypocretins, are two neuropeptides (orexin A and B or hypocretin 1 and 2) produced by a few thousand neurons located in the lateral hypothalamus that were independently discovered by two research groups in 1998. Those two peptides bind two receptors (orexin/hypocretin receptor 1 and receptor 2) that are widely distributed in the brain and involved in the central physiological regulation of sleep and wakefulness, orexin receptor 2 having the major role in the maintenance of arousal. They are also implicated in a multiplicity of other functions, such as reward seeking, energy balance, autonomic regulation and emotional behaviours. The destruction of orexin neurons is responsible for the sleep disorder narcolepsy with cataplexy (type 1) in humans, and a defect of orexin signalling also causes a narcoleptic phenotype in several animal species. Orexin discovery is unprecedented in the history of sleep research, and pharmacological manipulations of orexin may have multiple therapeutic applications. Several orexin receptor antagonists were recently developed as new drugs for insomnia, and orexin agonists may be the next‐generation drugs for narcolepsy. Given the broad range of functions of the orexin system, these drugs might also be beneficial for treating various conditions other than sleep disorders in the near future.
Mycoheterotrophic plants preferentially target arbuscular mycorrhizal fungi that are highly connected to autotrophic plants
Authors: Gomes Sofia I. F. , Fortuna Miguel A. , Bascompte Jordi , Merckx Vincent S. F. T. 
Published: June 2022

Summary

How mycoheterotrophic plants that obtain carbon and soil nutrients from fungi are integrated in the usually mutualistic arbuscular mycorrhizal networks is unknown. Here, we compare autotrophic and mycoheterotrophic plant associations with arbuscular mycorrhizal fungi and use network analysis to investigate interaction preferences in the tripartite network.

We sequenced root tips from autotrophic and mycoheterotrophic plants to assemble the combined tripartite network between autotrophic plants, mycorrhizal fungi and mycoheterotrophic plants. We compared plant–fungi interactions between mutualistic and antagonist networks, and searched for a diamond‐like module defined by a mycoheterotrophic and an autotrophic plant interacting with the same pair of fungi to investigate whether pairs of fungi simultaneously linked to plant species from each interaction type were overrepresented throughout the network.

Mycoheterotrophic plants as a group interacted with a subset of the fungi detected in autotrophs but are indirectly linked to all autotrophic plants, and fungi with a high overlap in autotrophic partners tended to interact with a similar set of mycoheterotrophs. Moreover, pairs of fungi sharing the same mycoheterotrophic and autotrophic plant species are overrepresented in the network.

We hypothesise that the maintenance of antagonistic interactions is maximised by targeting well linked mutualistic fungi, thereby minimising the risk of carbon supply shortages.
Data‐driven polyline simplification using a stacked autoencoder‐based deep neural network
Authors: Yu Wenhao , Chen Yujie 
Published: June 2022

AbstractAutomatic simplification of polylines is an important issue in spatial database and mapping. Traditional rule‐based methods are usually limited in performance, especially when the man‐made rules have to be adapted to different polylines with different shapes and structures. Compared to the existing neural network methods focusing only on the output layer or the code layers for classification or regression, our proposed method generates multi‐level abstractions of polylines by extracting features from multiple hidden layers. Specifically, we first organize the cartographic polylines into the form of feature vectors acceptable to the neural network model. Then, a stacked autoencoder‐based deep neural network model is trained to learn the pattern features of polyline bends and omit unimportant details layer by layer. Finally, the multi‐level abstractions of input polylines are generated from different hidden layers of a single model. The experimental results demonstrate that, compared with the classic Douglas–Peucker and Wang and Muller algorithms, the proposed method is able to properly simplify the polylines while representing their essential shapes smoothly and reducing areal displacement.