bluuebunny/crossref_metadata_2025_split huggingface dataset:
Introducing a new method to record injuries during military training: a prospective study among 296 young Norwegian conscripts
Authors: Bjørneboe John , Heen A , Borud E , Bahr R , Clarsen B , Norheim A-J 
Published: June 2022

IntroductionMost epidemiological studies in the field of military medicine have been based on data from medical records and registries. The aims of this study were to test a self-reporting injury surveillance system commonly used in sports medicine in a military setting, and to describe the injury pattern among Norwegian army conscripts during a period of military training.MethodA total of 296 conscripts in His Majesty the King’s Guard were asked to report all injuries each week for 12 weeks, using a modification of the Oslo Sports Trauma Research Center Questionnaire on Health Problems (OSTRC-H2). We recorded all injuries irrespective of their need for medical attention or consequences for military participation. In addition, we retrieved data on injuries recorded by military physicians in the medical record from the Norwegian Armed Forces Health Register.ResultsThe mean weekly response rate was 74%. A total of 357 injuries were recorded, of which 82% were only captured through the OSTRC-H2 and 3% only in the medical records. The average weekly prevalence of injury was 28% (95% CI: 25% to 31%), and 10% (95% CI: 8% to 12%) experienced injuries with a substantial negative impact on training and performance. The greatest injury burden was caused by lower limb injuries, with knee and foot injuries as the predominant injury locations.ConclusionThe OSTRC-H2 is suitable for use in a military setting and records substantially more injuries than the standard medical record. The prevalence of injuries among conscripts is high and comparable with many elite sports.
Development of a novel predictive model for a successful stone removal after flexible ureteroscopic lithotripsy based on ipsilateral renal function: a single-centre, retrospective cohort study in China
Authors: Ma Yucheng , Jian Zhongyu , Xiang Liyuan , Zhou Liang , Jin Xi , Luo Deyi , Li Hong , Wang Kun-Jie 
Published: June 2022

ObjectivesThe aims of this study were to investigate the effect of preoperative ipsilateral renal function on the success of kidney stone removal with flexible ureteroscopic lithotripsy and to develop a predictive model based on the results.DesignRetrospective cohort study.SettingData from the 2001–2012 period were collected from the electronic records of West China Hospital, Sichuan University.Participants576 patients who underwent flexible ureteroscopic lithotripsy were included in the study.Primary outcomeStone-free rate (SFR) after the procedures.ResultsIn patients with suspected impaired kidney function, the overall SFR was 70.1%. Stone volume (OR 1.46; 95% CI 1.18 to 1.80), lower calyx stones (OR 1.80; 95% CI 1.22 to 2.65), age (OR 1.02; 95% CI 1.00 to 1.04), body mass index (OR 1.10; 95% CI 1.04 to 1.17) and estimated glomerular filtration rate of the affected kidney (OR 0.95; 95% CI 0.94 to 0.97) were identified as independent predictors of SFR. Lasso regression selected the same five predictors as those identified by univariate and multivariate logistic regression analyses, thus verifying our model. The mean area under the curve, based on 1000 iterations and 10-fold validation, was 0.715 (95% CI 0.714 to 0.716). The Hodges-Lehmann test and calibration curve analysis revealed no significant mismatch between the prediction model and the retrospective cohort.ConclusionIpsilateral renal function may be a novel independent risk factor for kidney stone removal with flexible ureteroscopic lithotripsy. A novel nomogram for predicting SFR that uses stone volume, lower calyx stones, age, body mass index and estimated glomerular filtration rate was developed, but remains to be externally validated.
Creating interventions to transition long-lasting insecticide net distribution in Ghana
Authors: Glozah Franklin , Asampong Emmanuel , Tabong Philip Teg-Nefaah , Nwameme Adanna , Hornuvo Ruby , Chandi Margaret , Peprah Nana Yaw , Adongo Philip , Dako-Gyeke Phyllis 
Published: June 2022

ObjectiveMass long-lasting insecticide net (LLIN) distribution campaigns are rolled out, as a part of the Ghana Malaria Strategic plan (2021–2025) which seeks to protect at least 80% of the population at risk with effective malaria prevention interventions. Although the mass LLIN distribution campaign indicates a comprehensive stakeholder engagement approach, it does not systematically transition into the basic primary healthcare structures within the Ghana Health Services. This paper presents the process and outcome of creating an innovative social intervention, which focuses on community mobilisation and capacity building of community health officers.MethodsThis study employed a concurrent triangulation mixed methods approach conducted across six districts in Eastern and Volta regions, Ghana. Findings were synthesised, grouped and further distilled to guide the participatory cocreation workshops. Cocreation involved participatory learning in action technique which is a practical, adaptive research strategy which enabled diverse groups and individuals to learn, work and act together in a cooperative manner.ResultsThe results suggest the establishment of a Community Health Advocacy Team (CHAT). This would be necessary in efforts aimed at transitioning LLIN distribution campaign in communities. The role of the CHAT would be centred on key elements of community/social mobilisation and capacity building, all nested in a social and behaviour change communication strategies.ConclusionThe research team is in the process of assessing the acceptability and feasibility of the CHAT intervention with all stakeholders in the various communities. Assessment of the effectiveness of the CHAT intervention would be done at a later time.
Relationships between self-reflectiveness and clinical symptoms in individuals during pre-morbid and early clinical stages of psychosis
Authors: Xu Lihua , Cui Huiru , Wei Yanyan , Qian Zhenying , Tang Xiaochen , Hu Yegang , Wang Yingchan , Hu Hao , Guo Qian , Tang Yingying , Zhang Tianhong , Wang Jijun 
Published: June 2022

BackgroundSelf-reflectiveness, one dimension of cognitive insight, plays a protective role in an individual’s mental state. Both high and low levels of self-reflectiveness have been reported in patients with schizophrenia and individuals at clinical high risk for the illness.AimsThis study aimed to explore the relationship patterns between self-reflectiveness and clinical symptoms in individuals during the pre-morbid and early clinical stages of psychosis.MethodsA total of 181 subjects, including individuals with attenuated positive symptoms (APS, n=122) and patients with first-episode psychosis (FEP, n=59), completed the Beck Cognitive Insight Scale and were evaluated using the Schedule of Assessment of Insight and Positive and Negative Syndrome Scale. All subjects were classified into three groups according to their level of self-reflectiveness: low level (LSR, n=59), medium level (MSR, n=67) and high level (HSR, n=55). Both linear and non-linear relationships between self-reflectiveness and clinical symptoms were explored.ResultsMore individuals with APS were classified into the MSR group, while more patients with FEP were classified into the LSR group. The LSR group demonstrated less awareness of illness than the MSR and HSR groups, more stereotyped thinking and poorer impulse control but less anxiety than the MSR group, and lower levels of blunted affect and guilt feelings than the HSR group. The MSR group demonstrated lower stereotyped thinking than the HSR group. Compared to the LSR group, the MSR group had increased self-reflectiveness, improved awareness of illness, decreased stereotyped thinking, and better impulse control, but increased feelings of guilt. The HSR group showed increased stereotyped thinking when compared to the MSR group, but the other variables did not change significantly between these two groups. Overall, self-reflectiveness demonstrated an approximately inverse S-shaped relationship with the awareness of illness, a U-shaped relationship with stereotyped thinking and poor impulse control, and an almost linear relationship with anxiety and guilt feelings.ConclusionsSelf-reflectiveness demonstrates complex relationships with clinical symptoms and fails to exert significant positive effects when reaching a certain high level.
Covalent ERα Antagonist H3B-6545 Demonstrates Encouraging Preclinical Activity in Therapy-Resistant Breast Cancer
Authors: Furman Craig , Puyang Xiaoling , Zhang Zhaojie , Wu Zhenhua J. , Banka Deepti , Aithal Kiran B. , Albacker Lee A. , Hao Ming-Hong , Irwin Sean , Kim Amy , Montesion Meagan , Moriarty Alyssa D. , Murugesan Karthikeyan , Nguyen Tuong-Vi , Rimkunas Victoria , Sahmoud Tarek , Wick Michael J. , Yao Shihua , Zhang Xun , Zeng Hao , Vaillancourt Frédéric H. , Bolduc David M. , Larsen Nicholas , Zheng Guo Zhu , Prajapati Sudeep , Zhu Ping , Korpal Manav 
Published: June 2022

Abstract

Nearly 30% of patients with relapsed breast cancer present activating mutations in estrogen receptor alpha (ERα) that confer partial resistance to existing endocrine-based therapies. We previously reported the development of H3B-5942, a covalent ERα antagonist that engages cysteine-530 (C530) to achieve potency against both wild-type (ERαWT) and mutant ERα (ERαMUT). Anticipating that the emergence of C530 mutations could promote resistance to H3B-5942, we applied structure-based drug design to improve the potency of the core scaffold to further enhance the antagonistic activity in addition to covalent engagement. This effort led to the development of the clinical candidate H3B-6545, a covalent antagonist that is potent against both ERαWT/MUT, and maintains potency even in the context of ERα C530 mutations. H3B-6545 demonstrates significant activity and superiority over standard-of-care fulvestrant across a panel of ERαWT and ERαMUT palbociclib sensitive and resistant models. In summary, the compelling preclinical activity of H3B-6545 supports its further development for the potential treatment of endocrine therapy–resistant ERα+ breast cancer harboring wild-type or mutant ESR1, as demonstrated by the ongoing clinical trials (NCT03250676, NCT04568902, NCT04288089).

Summary:
H3B-6545 is an ERα covalent antagonist that exhibits encouraging preclinical activity against CDK4/6i naïve and resistant ERαWT and ERαMUT tumors.
Characterization of Phrenic Nerve Response to Pulsed Field Ablation
Authors: Howard Brian , Haines David E. , Verma Atul , Kirchhof Nicole , Barka Noah , Onal Birce , Stewart Mark T. , Sigg Daniel C. 
Published: June 2022

Background:
Phrenic nerve palsy is a well-known complication of cardiac ablation, resulting from the application of direct thermal energy. Emerging pulsed field ablation (PFA) may reduce the risk of phrenic nerve injury but has not been well characterized.

Methods:
Accelerometers and continuous pacing were used during PFA deliveries in a porcine model. Acute dose response was established in a first experimental phase with ascending PFA intensity delivered to the phrenic nerve (n=12). In a second phase, nerves were targeted with a single ablation level to observe the effect of repetitive ablations on nerve function (n=4). A third chronic phase characterized assessed histopathology of nerves adjacent to ablated cardiac tissue (n=6).

Results:

Acutely, we observed a dose-dependent response in phrenic nerve function including reversible stunning (R
2
=0.965,
P
<0.001). Furthermore, acute results demonstrated that phrenic nerve function responded to varying levels of PFA and catheter proximity placements, resulting in either: no effect, effect, or stunning. In the chronic study phase, successful isolation of superior vena cava at a dose not predicted to cause phrenic nerve dysfunction was associated with normal phrenic nerve function and normal phrenic nerve histopathology at 4 weeks.

Conclusions:
Proximity of the catheter to the phrenic nerve and the PFA dose level were critical for phrenic nerve response. Gross and histopathologic evaluation of phrenic nerves and diaphragms at a chronic time point yielded no injury. These results provide a basis for understanding the susceptibility and recovery of phrenic nerves in response to PFA and a need for appropriate caution in moving beyond animal models.
Linear and Nonlinear Digital Filters: From the Analog and Beyond
Authors: Lazzarini Victor , Timoney Joseph 
Published: June 2022

Abstract
A common approach in the development of digital filters is to begin with an existing analog filter and produce an equivalent computer program to realize it. This may involve, at the extreme, the detailed analysis of circuit behavior, or it may stem from a higher-level approach that looks at block diagrams and s-domain transfer functions. In this article, we first take the latter approach to develop a set of linear filters from the well-known state variable filter. From this we obtain a first result, which is a linear digital implementation of the Steiner design, comprising separate inputs for different frequency responses and a single output summing the responses. Turning back to the state variable design, we show that to develop a nonlinear version, an analog circuit realization can be used to identify positions in which to insert nonlinear waveshapers. This gives us our second result, a nonlinear digital state variable filter. From this analog-derived design, we then propose modifications that go beyond the original filter, developing as a final result a structure that could be classed as a hybrid of filter and digital waveshaper. As part of this process, we ask the question of whether an approach that takes inspiration from the analog world, while being decoupled from it, may be more profitable in the long run than an obsession with detailed circuit modeling.
Gay Identity, Same-Sex Relationships, and Military Service
Authors: Zaritsky Yoav , Yonay Yuval 
Published: June 2022

Abstract
This article deals with the history of military service for gay men in the Israeli army (Israel Defense Forces, idf), during the years 1948 to the mid-1970s. It is based primarily on the oral testimonies of thirty-two Israeli gay men born between 1924–1948, juxtaposed with historical sources such as newspaper articles, court documents, and written idf guidelines. Through these, we will examine popular conceptions and understandings of deviant sexuality in the idf between the 1950s and the 1970s, and in Israel in general. We will explore the question of homosexuals’ enrolment in the idf and related idf policies throughout the years, as well as various strategies adopted by homosexuals in Israel to negotiate their sexuality during their service. Ours is the first study on real-life experiences of gays who served their military duty during the early decades of the idf.
Sexual Orientation and Food Hardship: National Survey of Family Growth, 2011-2019
Authors: Han Beenna , Hernandez Daphne C. 
Published: June 2022

Objective: Given the high rates of poverty observed among sexual minority groups and their social vulnerability, we examined the prevalence and correlation of food hardship, measured as food insecurity, receipt of free or reduced-cost food, and Supplemental Nutrition Assistance Program (SNAP) participation among low-income sexual minority and heterosexual adults using population-level health surveillance data. Methods: We used 4 waves of pooled data (2011-2019) from the National Survey of Family Growth for adults aged 18-44 years. We compared the sexual orientation subgroups and used logistic regression to predict the likelihood of food hardship. Results: Among men, gay and bisexual men had higher odds of experiencing food insecurity than their heterosexual counterparts (adjusted odds ratio [aOR] = 1.97 and 1.83, respectively). Compared with heterosexual men, bisexual men had significantly higher odds of receiving free or reduced-cost food, but gay men did not. The odds of participating in SNAP did not differ significantly among gay, bisexual, and heterosexual men. Among women, only bisexual women were more prone to experiencing food insecurity than their heterosexual counterparts (aOR = 1.81). The odds of receiving free or reduced-cost food did not differ significantly among heterosexual, bisexual, and lesbian women. However, compared with heterosexual women, lesbian women had significantly lower odds (aOR = 0.62) and bisexual women had significantly higher odds (aOR = 1.24) of participating in SNAP. Conclusion: Our findings contribute to the limited literature examining trends in food hardship among sexual minority groups and suggest potentially different patterns of food insecurity, food assistance, and SNAP participation among sexual orientation subgroups, which may call for group-specific, nuanced approaches for lessening food hardship.
The Power of Mothers and Teachers Engaging in a Mathematics Bilingual Collaboration
Authors: Stoehr Kathleen , Salazar Fany , Civil Marta 
Published: June 2022

Background: Making mathematics connections between home and school can have a positive impact on students’ mathematics learning. This is particularly important for students whose experiences and perspectives are underrepresented in school curricula. Although there is evidence for how crucial it is to make connections between mathematics instruction and children’s lived experiences, doing so is often a challenging task for teachers. Purpose: This study examines what teachers in two different settings—a dual language school and a Structured English Immersion school—learned from engaging in a mathematics collaboration with Latina mothers. We share the teachers’ perceptions of their students’ and families’ mathematics’ strengths and how they envisioned their future mathematics teaching. Research Design: This qualitative interpretive study explored how 15 teachers from two states made sense of their experiences working together in a two-year mathematics collaboration with mothers from their school community. We collected multiple teacher reflections and artifacts, and administered a small group interview with teachers and parents and an individual teacher interview. We used an iterative analysis by demarcating the words that pertained to the different data sources, as we looked for patterns of the teachers’ key ideas. We summarized the key ideas across the data sources that resulted in six major themes. Findings: The key findings in this study reveal that the teachers learned from the mothers more about their students’ lives outside of school, the mothers’ mathematics background, and ways to create multiple channels of communication with the mothers. The teachers also learned about the significant contributions that the mothers make to their children’s mathematics education and the importance of honoring the mothers’ ways of doing mathematics in their mathematics teaching. The teachers shared how the collaboration with the mothers helped to serve as a guide to leverage their students’ learning of mathematics in Spanish and English. Conclusions/Recommendations: This study suggests that mathematics collaborations between teachers and parents can be highly beneficial to student learning. It showcases the importance of providing teachers with opportunities to learn about the rich mathematics knowledge that parents from diverse backgrounds possess. This study also demonstrates that creating authentic relationships that enhance mutual understandings between teachers and parents can be key in supporting Latinx students’ mathematics learning. We recommend that these types of collaborations between teachers and parents be considered part of the preparation of preservice teachers as well as the professional learning of in-service teachers.
Changes in Bone Mineral Density of the Femur and Tibia Before Injury to 2 Years After Anterior Cruciate Ligament Reconstruction in Division I Collegiate Athletes
Authors: Knurr Keith A. , Kliethermes Stephanie A. , Haack Colten R. , Olson Justin S. , Binkley Neil C. , Scerpella Tamara A. , Heiderscheit Bryan C. 
Published: June 2022

Background: Osteoarthritis (OA) is a significant long term concern after anterior cruciate ligament (ACL) reconstruction (ACLR). A low bone mineral density (BMD), particularly in the subchondral region, has been associated with the development of OA and is evident at the knee in patients long after ACLR. It is unknown if persistent BMD deficits are present in high level collegiate athletes. Purpose/Hypothesis: The purpose of this study was to evaluate bilateral changes in the BMD of the femur and tibia from before the injury to 24 months after ACLR in collegiate athletes. We hypothesized that the BMD of both the distal femur and the proximal tibia would be significantly reduced within the surgical limb initially postoperatively but return to preinjury levels by 24 months after ACLR. Study Design: Cohort study; Level of evidence, 2. Methods: A total of 33 Division I collegiate athletes were identified between 2010 and 2021 (13 female) who underwent total body dual-energy X-ray absorptiometry (DXA) before sustaining an ACL injury. DXA was repeated at 6, 12, and 24 months after ACLR. Linear mixed effects models assessed differences in the BMD at 5%, 15%, and 50% of the femur's length (F5, F15, F50) and at 5%, 15%, and 50% of the tibia's length (T5, T15, T50) within each limb from before the injury to 24 months after ACLR, reported as Tukey-adjusted P values. Results: Compared with before the injury, the BMD at F5 of the surgical limb was reduced by 0.15 g/cm2 (SE, 0.02 g/cm2) at 6 months ( P < .001). The BMD at F15 of the surgical limb was reduced by 0.06 g/cm2 (SE, 0.01 g/cm2), 0.09 g/cm2 (SE, 0.01 g/cm2), and 0.09 g/cm2 (SE, 0.01 g/cm2) at 6, 12, and 24 months, respectively (all P < .001). The BMD at T5 of the nonsurgical limb was reduced by 0.07 g/cm2 (SE, 0.02 g/cm2) at 12 months ( P = .02) and 0.10 g/cm2 (SE, 0.02 g/cm2) at 24 months ( P = .001). The BMD at T15 of the surgical limb was reduced by 0.07 g/cm2 (SE, 0.01 g/cm2) at 6 months and 0.08 g/cm2 (SE, 0.02 g/cm2) at 12 months ( P < .001). Conclusion: BMD deficits at F15 of the surgical limb persisted out to 24 months (–7.1%) after ACLR compared with before the injury in collegiate athletes. The BMD at F5 and T15 of the surgical limb was reduced at 6 and 12 months but not at 24 months compared with preinjury levels. For the nonsurgical limb, no significant differences were detected, except for the T5 region at 12 months (–5.1%) and 24 months (–7.2%). The BMD at F50 and T50 of both limbs was not significantly different than preinjury levels at any time after ACLR.