bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identificação Organizacional Cooperativa: a influência de um Novo Construto sobre o Clima Organizacional
Authors: Bento Marcia Helena dos Santos , Da Rosa Gama Madruga Lucia Rejane , Stecca Jaime Peixoto , Estivalete Vania de Fátima Barros 
Published: January 2022

- Objetivo da pesquisa: Analisar a influência da identificação organizacional cooperativa sobre o clima organizacional.
- Enquadramento teórico: Teoria da Identidade Organizacional (Ashforth, & Mael, 1989)
- Metodologia: Foi realizada uma survey a partir de uma escala de Identificação Organizacional construída especificamente para as cooperativas juntamente com uma escala reduzida de clima organizacional adaptada transculturalmente para as cooperativas. A análise dos dados foi realizada com abordagem quantitativa, utilizando as técnicas de análise fatorial exploratória e confirmatória.
- Resultados: A análise de caminhos estruturais revelou que o construto ‘Ajuste ao Grupo’ é o que mais influencia o Clima Organizacional. O modelo final validado combinou um construto de segunda ordem, 4 construtos de primeira ordem e 17 variáveis. Os resultados finais do modelo demonstraram que o Clima Organizacional é 83,7% explicado por seus aspectos Afetivo, Cognitivo e Instrumental.
- Originalidade: As cooperativas possuem diversas características que as diferenciam de sociedades convencionais, e por isso necessitam de construtos teóricos adequados a sua realidade. As características diferenciadoras das cooperativas são autodeclaradas mundialmente, mas não foram estudadas a partir da Teoria da Identidade Organizacional.
- Contribuições teóricas e práticas: A presente pesquisa desenvolve um novo construto e escala denominados Identidade Organizacional Cooperativa. A escala de Clima Organizacional foi traduzida e adaptada transculturalmente para a realidade das cooperativas brasileiras.
- Palavras-chave: Identidade Organizacional. Identificação Organizacional. Clima Organizacional. Cooperativas. Cooperativas de Crédito.
Clinical manifestations of familial exudative vitreoretinopathy in children with nucleotide sequence alterations in the FZD4 gene
Authors: Katargina L. A. , Kadyshev V. V. , Denisova E. V. , Geraskina E. A. , Marakhonov A. V. , Garifullina S. A. , Zolnikova I. V. , Zinchenko R. A. 
Published: January 2022

Familial exudative vitreoretinopathy (FEVR)is a rare genetically heterogeneous disease with multiple types of inheritance (autosomal dominant, autosomal recessive, X-linked) and widely varying clinical features. Up to 40 % of cases of FEVR are associated with mutations of the FZD4 gene.Purpose: to investigate the clinical manifestations of FEVR in children with nucleotide sequence alterations in the FZD4 gene. Material and methods. The Helmholtz National Medical ResearchCenter of Eye Diseases and the ResearchCentre for MedicalGenetics conducted a joint in-depth ophthalmological examination of 18 patients aged from 3 weeks to 17 years with a diagnosis of FEVR, which included a detailed ophthalmoscopy under drug mydriasis, ultrasound and electrophysiological examination, photographic recording of fundus changes using RetCam and Fundus Foto. Molecular genetic examination was carried out by direct sequencing according to Sanger. Results. Nucleotide sequence alterations in the FZD4 gene were detected in 3 patients(16.7 %)from two unrelated families. In one family, a 12-year-old girl wasfound to display the firstsymptoms of ophthalmic pathology (reduced vision, strabismus) at the age of 3.5 years. In another family, the clinical manifestations of FZD4 gene mutations were observed in two children during the first year of life (at the age of 5 and 11 months).Conclusions. The clinical picture of 3 patients with detected changes in the nucleotide sequence of the FZD4 gene is characterized by early manifestation and bilateral asymmetric ophthalmoscopic damage. The results of the study indicate the need for a timely diagnosis of FEVR in young children, recommend an interdisciplinary approach to the study of the disease, which should contribute to a better understanding of pathogenesis, and the development of an effective diagnostic, treatment and rehabilitation algorithm.
A spectrofluorimetric study of the limbal area in patients with primary open-angle glaucoma
Authors: Neroev V. V. , Gar’kavenko V. V. , Salmin V. V. 
Published: January 2022

Purpose: to evaluate hypoxic changes in the limbus area conjunctiva of patients with primary open-angle glaucoma (POAG) treated with prolonged instillations of prostaglandin (PG) analogs. Material and methods. A spectrofluorimetric study of the limbus zone was carried out in 202 patients aged 56–87 years with POAG in the developed and advanced stages, divided into 2 groups. Group 1 consisted of patients aged 69.4 ± 10.3 years who received beta-blockers (BB) and carbonic anhydrase inhibitors (ICA) for 5–10 months; of these, 39 (30.2 %) had a developed stage of POAG and 90 (69.7 %) had advanced POAG. Group 2, aged 72.3 ± 9.4, received PG analogs, in addition to BB and ICA, for 5–10 months. In this group, 21 (28.7 %) patients had developed POAG and 52 (71.23 %) had advanced POAG. Results. The patients who received PG instillations showed a significantly higher ratio of fluorescence intensity in the wavelength range of 410/520 nm NADH/FAD (0.352 ± 0.043) than those receiving no such therapy (0.319 ± 0.047), which can be interpreted as a hypoxic state of the limbus area. Conclusion. Spectrofluorimetric testing of POAG patients taking PG analogs can be useful for detecting ischemia in the limbus area, because this category of patients are very likely to form cicatricial changes in the area of the filtration cushion in the early postoperative period after antiglaucomatous interventions.
Quality of life of a patient with computer vision syndrome depending on the type of accommodative astenopia
Authors: Ovechkin I. G. , Konovalov М. E. , Kovrigina E. I. , Leksunov O. G. , Yudin V. E. 
Published: January 2022

Purpose: a comparative assessment of the quality of life (QOL) of patients with symptoms of computer vision syndrome (CVS), depending on the type of accommodative asthenopia: habitual excessive accommodation stress (HEAS) and the asthenic form of accommodative asthenopia (AFAA). Material and methods. 60 patients aged 22–34 engaged in visually extensive work who had typical asthenopic complaints were examined. The main criterion for diagnosing the type of asthenopia was the coefficient of ciliary muscle microfluctuation, measured by objective accommodation on a Righton Speedy-I device (Japan). The patients were divided into two groups of 30 people each with similar age and sex distribution, corresponding to the two forms of asthenopia studied. The main method of QOL examination was the study of an innovative CVS-22 questionnaire filled in by the testees. Results. The comparative assessment of the overall test indicator revealed no significant differences between the examined groups of patients with HEAS (QOL = 40.2 ± 1.2 pts) and AFAA (QOL = 42.2 ± 1.0 pts), p > 0.05. For some of the complaints, certain differences were found, partly associated with the pathogenesis of HEAS and AFAA, however, they do not fully reflect the “specificity” of the main types of accommodative asthenopia. Conclusion. The results obtained indicate the absence of reliable subjective diagnostic criteria of CVS. The fact may be associated with a wide range of risk factors for the development of functional disorders of the body in general and the visual system in particular when the patients is engaged in activities requiring the use of electronic systems in information management.
The effect of phenylephrine hydrochloride 2.5 % and sodium hyaluronate solution on visual functions and accommodation in children with myopia and its local tolerability
Authors: Tarutta E. P. , Tarasova N. A. , Milash S. V. , Markosian G. A. , Kushnarevich N. Yu. , Larina T. Yu. 
Published: January 2022

Purpose: to evaluate visual functions, accommodation, and local tolerance in children instilled with Phenylephrine hydrochloride 2.5 % and sodium hyaluronate solution (Stelphrin Supra). Material and methods. 30 children (60 eyes) aged 8 to 12 (ave. 10.04 ± 0.24) with low (28 eyes) and moderate (32 eyes) myopia (ave. -2.96 ± 0.17 D) were tested. Refractometry, subjective and objective accommodation, optical biometry, anterior corneal surface examination, Norn test, and polling were performed prior to one-time instillation, 30 minutes after it, and after 1 month of daily bedtime instillations of Stelphrin Supra. Results. We noted a significant decrease in the tone of accommodation in the open field by 90 % from the initial value, an approximation of the nearest point of clear vision by 27 %, an increase in the volume of absolute accommodation by 57 % and the objective amplitude of accommodation by 20 %, which indicates an increase in the accommodation ability. The pupil width increased 30 minutes after a single instillation of Stelphrin Supra, which coincided with an increase in the relative accommodation reserve by 25 % from the initial one. After a month, the pupil width significantly decreased, and the positive relative accommodation reserve decreased to a level only 12 % higher than the original one. Tear film break time significantly increased by 0.89 sec, singular spot stainings disappeared in 2 out of 6 patients, lacrimation — in 6 out of 10, pain — in 1 out of 2, blurring in 4 out of 6, feeling of “sand” — in 7 out of 9 patients who had these symptoms before instillations. Conclusion. Regular instillations of Stelphrin Supra reduce the habitual tone of accommodation, increase the accommodation ability, and improve the condition of the eye surface.
The role of optical coherence tomography angiography biomarkers in assessing the outcome of long-term anti-VEGF therapy of diabetic macular edema
Authors: Fursova A. Zh. , Derbeneva A. S. , Tarasov M. S. , Vasil’eva M. V. , Gamza J. A. , Chubar N. V. 
Published: January 2022

The purpose of the study was to assess the changes of biomarkers of diabetic macular edema activity by optical coherence tomography angiography (OCTA) data and the relationship of these biomarkers with the response to anti-VEGF therapy during a two-year follow-up. Material and methods. The study included 59 patients (101) eyes, averagely aged 60.27 ± 9.50 years. The average number of intravitreal injections of aflibercept over the treatment period was 12.87 ± 3.50. The initial size of the foveolar avascular zone (FAZ) area — 0.37 ± 0.22 mm2 , and the acircularity index — 0.56 ± 0.14 remained unchanged after 5 months: 0.36 ± 0.24 mm2 and 0.56 ± 0.12, respectively, and being practically in the same level in 12 and 24 months. The large FAZ area, noted in the group where disorganization of retinal inner layers (DRIL) was observed (0.39 ± 0.21 mm2 ), correlated with a lower visual acuity (r = 0.67, p = 0.003). The acircularity index remained unchanged; no significant differences were found in the DRIL patient groups. After 5 loading injections, the average initial density of vessels in the macular region increased from 12.33 ± 3.86 mm to 12.75 ± 1.14 mm, after 1 year it was 13.48 ± 1.15 mm, after 2 years — 13.25 ± 3.39 mm. The average density of retinal perfusion increased at the 5th month from 29.81 ± 10.85 % to 31.55 ± 2.34 %, after 12 months to 32.91 ± 3.45, and by the end of the observation period to 31.41 ± 9.79 %. In the DRIL group, the baseline vascular density and mean perfusion volume were significantly lower: 11.17 ± 2.09 mm vs. 13.49 ± 1.14 mm and 28.40 ± 4.53 % vs. 31.20 ± 2.44 %). Conclusion. DRIL, a biomarker reflecting impaired capillary blood flow in the superficial capillary plexus and correlating with functional results, can be used as a predictor of antiangiogenic therapy effectiveness. After antiangiogenic therapy with DMO, the microcirculation indices (FAZ and acircularity) remained stable, and the vascular density and perfusion volume tended to increase, which testifies to the absence of ischemic damage.
Sistemas agroalimentarios periurbanos: relaciones de proximidad rural-urbano en Coatepec, Ixtapaluca, México
Authors: Moreno Gaytán Silvia Iveth 
Published: January 2022

La recuperación de cultivos emblemáticos para reconstruir sistemas agroalimentarios en territorios cambiantes
Resumen
El artículo es resultado de una investigación sobre la territorialidad y los sistemas agroalimentarios en el Oriente del Estado de México. El objetivo es mostrar las prácticas que las comunidades reconstruyen desde ámbitos locales para recuperar y rescatar alimentos con valor histórico y de proximidad cultural, vinculados y anclados a un territorio, aprovechando su interrelación con la ciudad. Los datos son hallazgos de herramientas de investigación cualitativa y el uso de técnicas cartográficas en Coatepec, pueblo productor de maguey, ubicado en el municipio de Ixtapaluca perteneciente al Estado de México. Los resultados señalan la forma en la que el territorio es producto y productor de fenómenos sociales que se reconfiguran a una escala regional en un contexto global.
Palabras clave: territorio, alimentos, local, proximidad, rural
ALLERGIC RHINITIS AND IMPORTANCE OF FEXOFENADINE HCL SUSTAINED RELEASE MICROSPHERE AS ITS TREATMENT APPROACH
Authors: AREFIN PAROMA , HABIB MD SHEHAN , AHMED NAZIM UDDIN , RAHIM MD ABDUR , IBRAHIM MD , BHATTACHARJEE SREEBASH CHANDRA , CHAKRABORTY DIPANKAR , DAS SUMON , KARMAKAR DEBABRATA , BHOWMIK DIP , ISLAM SHIRMIN , AREFIN MD SAIDUL 
Published: January 2022

The current treatment approaches for allergic rhinitis are practiced over decades, but the patient quality of life has not yet changed so much. The reasons are research gaps in pathophysiology of the disease, proper management of the disease. Fexofenadine HCl is a second-generation antihistamine drug which has a half-life of about 14.4 h. It is useful in the management of common symptoms like sneezing, itchy throat, and red eyes in individuals suffering from allergic rhinitis. Fexofenadine immediate release or sustained release formulations are available in the market as suspension, tablet and capsule. In this research paper, we have discussed the symptoms associated with allergic rhinitis and treatment approaches. Fexofenadine HCl is being used for the treatment of this disease. But as it has a long half-life, we have discussed the importance of the introduction of sustained-release microsphere formulation of Fexofenadine HCl in the market.
HIGH-THROUGHPUT SCREENING AND DYNAMIC STUDIES OF SELECTED COMPOUNDS AGAINST SARS-COV-2
Authors: BHOWMIK RATUL , NATH RANAJIT , SHARMA SAMEER , ROY RATNA , BISWAS RIYA 
Published: January 2022

Objective: This study was aimed to analyze the inhibitory effect of the drugs used in nanocarrier as well as nanoparticles formulation based drug delivery system selected from PubChem database literature against 3CLpro (3C-like protease) receptor of SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) by implementing several in silico analysis techniques.
Methods: This paper detailed a molecular docking-based virtual screening of 5240 compounds previously utilized in nanoparticle and nanocarrier drug delivery systems utilizing AutoDock Vina software on 3CL protease to discover potential inhibitors using a molecular docking technique.
Results: According to the results of the screening, the top two compounds, PubChem Id 58823276 and PubChem Id 60838 exhibited a high affinity for the 3CL protease binding region. Their binding affinities were-9.6 and-8.5 kJ/mol, indicating that they were tightly bound to the target receptor, respectively. These results outperformed those obtained using the co-crystallized native ligand, which exhibited a binding affinity of-7.4 kJ/mol. PubChem Id 60838, the main hit compound in terms of both binding affinity and ADMET analysis, displayed substantial deformability after MD simulation. As a result of the VS and molecular docking techniques, novel 3CL protease inhibitors from the PubChem database were discovered using the Lipinski rule of five and functional molecular contacts with the target protein, as evidenced by the findings of this work.
Conclusion: The findings suggest that the compounds discovered may represent attractive opportunities for the development of COVID-19 3CLpro inhibitors and that they need further evaluation and investigation.
DEVELOPMENT, OPTIMIZATION AND EVALUATION OF PULSATILE DRUG DELIVERY CAPSULES LOADED WITH CARVEDILOL BY APPLYING QUALITY BY DESIGN
Authors: KUMAR A. BHARATH , KUMAR GAUTAM GIRENDRA , B. SYED SALMAN 
Published: January 2022

Objective: The purpose of this research is to find the best way for designing carvedilol pulsatile drug delivery system capsules.
Methods: The research paves the way to improve the method of preparing carvedilol pulsatile drug delivery by adjusting critical material attributes (CMA) such as coating polymer concentration, critical process parameters (CPP) such as inlet temperature and atomizing air pressure, and their impact on critical quality attributes (CQA) like particle size (PS in nm), entrapment efficiency in percentage (% EE) and amount of drug delivered in percent (%ADR) at 12 h in the carvedilol pulsatile pellets filled capsules by applying the Box-Behnken design. By varying the polymer concentration and process parameters, nearly 15 formulations were created.
Results: Based on the influence of CMA, CPP on CQA, the formulation CP13 was determined to be the most optimized formulation among the 15 formulations. The optimized levels of CMA were found to be-1 level of coating polymer concentration and CPP was found to be-1 level of inlet temperature, 0 level of atomizing air pressure and it optimized CQA like PS was found to be 1017.5±8.4 nm, % EE was found to be 96.8±2.8 %, % ADR at 12 h was found to be 88.4±3.4 %. Carvedilol Pulsatile drug delivery system was designed by using optimized fluidized bed coater in order to decrease the usage of attributes, decrease the productivity cost and enhance the usage of specific attributes at fixed concentration for further manufacturing scale.
Conclusion: By the current results it was concluded that the optimized CMA and CPP that shown in the results are the suitable attributes for the best formulation of carvedilol pulsatile drug delivery system capsules.
PHYSICOCHEMICAL PROPERTIES AND NUTRITION OF MORINGA OLEIFERA LAM. LEAF EXTRACT: A PRELIMINARY STUDY ON PREPARATION PHYTOSOMES AS HERBAL SUPPLEMENT FOR CHILDREN
Authors: WARDANA MUTIA SARI , JUFRI MAHDI , MUN’IM ABDUL 
Published: January 2022

Objective: The study aimed to evaluate the physicochemical properties and nutrition of Moringa leaf extract. In addition, the preliminary study for the preparation of Moringa leaf extract-loaded phytosomes for a supplement.
Methods: Extraction of Moringa leaf made using microwave-assisted extraction, followed by evaluation of proximate analysis (water, total ash, acid-insoluble of ash contents, and residual n-hexane), phytochemical screening, and nutrition such as crude protein, amino acids, and minerals (iron, zinc, and calcium). The phytosomes were prepared by the anti-solvent precipitation method and assessed for the morphology, particle size, zeta potential, polydispersity index (PDI), entrapment efficiency (EE), and Fourier-transform infrared spectra.
Results: The nutrition contents of crude protein, iron, zinc, and calcium were 19.61±0.07%, 3.47±0.00 mg/100g, 5.46±0.05 mg/100g, and 747.40±4.89 mg/100g, respectively. The amino acids with the highest concentrations were glutamic acid, phenylalanine, aspartic acid, alanine, and arginine in the extract. The best preparation using sonication 10 min by morphology was a spherical included particle size, PDI, zeta potential, and EE of arginine was 87.16±1.73 nm, 0.22±0.04, −23.07±0.76 mV, and 108.94±0.52%, respectively.
Conclusion: These preliminary results provide evidence of the nutritional benefit of Moringa leaf extract-loaded phytosomes as a promising supplement to prevent stunting in children.
Application of Higher Order Ordinary Differential Equation Model in Financial Investment Stock Price Forecast
Authors: Zhang Liqin , Tian Xiaojing , Chabani Zakariya 
Published: January 2022

Abstract
In order to improve the modelling efficiency in dynamic system prediction, this paper proposes a predictive model based on high-order normal differential equations to model high-order differential data to obtain an explicit model. The high-order constant differential equation model is reduced, and the numerical method is used to solve the predictive value. The results show that the method realises the synchronisation of model establishment and parameter optimisation, and greatly enhances the modelling efficiency.
Theoretical Study of the Unconstrained and Constrained Nonlinear Optimal Discrete Time State Feedback Control
Authors: György Katalin , Dávid László 
Published: January 2022

AbstractMajority of the optimal control techniques can only be applied successfully if the model of the controlled process is known and it is linear. If the system model is nonlinear, then this nonlinear model can be approximated with different simple, linear models. However, these models are valid only in the neighbourhood of the operating points. The success of the control algorithms is highly dependent on the used linearization methods. The aim of the paper is to compare different optimal control algorithms and linearization methods. The presented optimal control algorithms have been also tested in constrained and unconstrained versions.
Image Processing Methods for Gesture-Based Robot Control
Authors: Zaatri Abdelouahab , Aboud Hamama 
Published: January 2022

AbstractIn this paper we discuss some image processing methods that can be used for motion recognition of human body parts such as hands or arms in order to interact with robots. This interaction is usually associated to gesture-based control. The considered image processing methods have been experienced for feature recognition in applications involving human robot interaction. They are namely: Sequential Similarity Detection Algorithm (SSDA), an appearance-based approach that uses image databases to model objects, and Kanade-Lucas-Tomasi (KLT) algorithm which is usually used for feature tracking. We illustrate the gesture-based interaction by using KLT algorithm. We discuss the adaptation of each of these methods to the context of gesture-based robot interaction and some of their related issues.
Filtering Random Valued Impulse Noise from Grayscale Images through Support Vector Machine and Markov Chain
Authors: Gellert Arpad , Brad Remus , Morariu Daniel , Neghina Mihai 
Published: January 2022

AbstractThis paper presents a context-based filter to denoise grayscale images affected by random valued impulse noise. A support vector machine classifier is used for noise detection and two Markov filter variants are evaluated for their denoising capacity. The classifier needs to be trained on a set of training images. The experiments performed on another set of test images have shown that the support vector machine with the radial basis function kernel combined with the Markov+ filter is the best configuration, providing the highest noise detection accuracy. Our filter was compared with existing denoising methods, it being better on some images and comparable with them on others.