bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Predictive and Empirical Analysis of CPI Rate on Key Financial Indicators
Authors: Hungund Bilal , Rastogi Shilpa 
Published: July 2022

Abstract
The assessment and performance of national economy involves the aggregation of major economic indicators. The Consumer Price Index is perhaps the most used indicator among the numerous statistical indicators that are available to the planners, administrators, policy makers and the general public at large to analyse the status of the national economy at any point of time. Additionally, the six core financial indicators of an Indian economy namely, foreign exchanges reserves, supply of money, nominal exchange rates, stock market index, country’s industrial production, and CPI rate have a significant relationship in the development of an economy. The aggregation of these indicators could imply that the change in one indicator may affect the other indicator. The relationship of the indicators was explored and it was concluded that there is a correlation between CPI rate and five specified key financial indicators (considering sub-components). Additionally, there is a multicollinearity present in the specified key financial indicators. Furthermore, by using a comprehensive data science tool a predictive deep learning model was built to predict the CPI rate.
Local neuroplasticity in adult glaucomatous visual cortex
Authors: Carvalho Joana , Invernizzi Azzurra , Martins Joana , Renken Remco J. , Cornelissen Frans W. 
Published: July 2022

Abstract
The degree to which the adult human visual cortex retains the ability to functionally adapt to damage at the level of the eye remains ill-understood. Previous studies on cortical neuroplasticity primarily focused on the consequences of foveal visual field defects (VFD), yet these findings may not generalize to peripheral defects such as occur in glaucoma. Moreover, recent findings on neuroplasticity are often based on population receptive field (pRF) mapping, but interpreting these results is complicated in the absence of appropriate control conditions. Here, we used fMRI-based neural modeling to assess putative changes in pRFs associated with glaucomatous VFD. We compared the fMRI-signals and pRF estimates in participants with glaucoma to those of controls with case-matched simulated VFD. We found that the amplitude of the fMRI-signal is reduced in glaucoma compared to control participants and correlated with disease severity. Furthermore, while coarse retinotopic structure is maintained in all participants with glaucoma, we observed local pRF shifts and enlargements in early visual areas, relative to control participants. These differences imply that the adult brain retains local neuroplasticity. This finding has translational relevance, as it is consistent with VFD masking, which prevents glaucoma patients from noticing their VFD and seeking timely treatment.
Photochemical growth of silver nanoplates on graphene oxide for the electrochemical sensing of hydrogen peroxide
Authors: Pilicita Johana , Briceño Sarah , Suppan Gottfried , Vizuete Karla , Debut Alexis 
Published: July 2022

Abstract
In this work, we growth silver nanoplates on graphene oxide (GO) as an electrochemical sensor for detecting hydrogen peroxide (H2O2). Silver nanoplates on GO were obtained by the in-situ photoreduction method at 540 nm excitation wavelength. The nanocomposites were characterized using UV-Vis spectroscopy, Scanning electron microscopy (SEM), Atomic force microscopy (AFM), Transmission electron microscopy (TEM), Raman spectroscopy, and the electrochemical properties were measured by cyclic voltammetry (CV). Our results reveal the transformation of quasi-spherical silver nanoparticles from 12 nm to planar faces of 25 nm on GO. The preeminent detection range for H2O2 determination was 0.4 mM to 3 mM with a detection limit of 0.28 mM and sensitivity of 444.51 µA mM−1 cm−2. The results reveal that a synergistic effect between silver nanoplates on GO enhances the electrochemical properties for the determination of H2O2.
Study of Thyroid function among COVID-19 affected and non-affected people during pre and post vaccination
Authors: Razu Mamudul Hasan , Hossain Md. Iqbal , Ahmed Zabed Bin , Bhowmik Mousumi , Hasan Md. Kazy Ebnul , Kibria Md. Kaderi , Moni Dil Afroz , Khan Mala 
Published: July 2022

Abstract
The novel coronavirus COVID-19 has caused a global pandemic with many long-ranging effects on the human body's physiological balance. The impact of COVID-19 on the thyroid axis remains uncertain. Our aim was to assess the long-term consequences of COVID-19 infection and its vaccination with thyroid hormones. Thirty laboratory-confirmed COVID-19-positive patients with no vaccination record, thirty COVID-19 negative patients with vaccination records, and ten healthy subjects were retrospectively and cross-sectionally enrolled in this study. An ELISA assay was used to evaluate the thyroid function tests, including total triiodothyronine (TT3), total thyroxine (TT4) and thyroid stimulating hormone (TSH). We found decreased levels of TT3, normal or low plasma T4 levels, and normal or slightly decreased TSH levels in unvaccinated COVID-19 positive patients than in the healthy group, while the vaccinated COVID-19 negative group had normal thyroid hormone levels compared to controls. The correlation between TT3 and TSH levels appeared to gradually shift from no association to a negative pattern in the unvaccinated COVID-19 positive group. Again, a highly significant negative correlation between TSH and TT3 was observed on days above 150, although a slight fluctuation was noted on day 90. This pilot study from Bangladesh shows that abnormalities in thyroid function can be observed during COVID-19 infection and after vaccination, which gradually recovers over time.
Factors associated with health facility delivery among reproductive age women in Nepal: An analysis of Nepal Multiple Indicator Cluster Survey 2019
Authors: Thapa Naba Raj , Upreti Shanti Prasad 
Published: July 2022

Abstract
BackgroundDelivery in health facility is an essentials factor in improving maternal health. Reducing maternal mortality is the one of the targets of Sustainable Development Goal 3. Health facility delivery is still major concern in Nepal. This study aims to determine the factors associated with delivery in health facility among women aged 15-49 years in Nepal. Methods This study used data from Nepal Multiple Indicator Cluster Survey 2019, a nationally representative cross-sectional survey. This survey was a two-stage, stratified cluster sampling. A total of 1,950 married women age 15-49 years who had at least one live birth in the last two years preceding the survey were included in the analysis. Bivariate and multivariate logistic regression analysis were performed in this study.ResultsSeventy-eight percent of women delivered in health facility. Women from urban area (AOR= 1.64, p<0.01), women residing in Sudurpaschim province (AOR=5.68, p<0.001), women who used internet (AOR=1.53, p<0.05), women with first parity (AOR=2.79, p<0.001), and women from richest household status (AOR= 6.10, p<0.005) and women who attained at least four ANC visits (AOR=12.77, p<0.001) were associated with higher odds of delivering in a health facility. ConclusionConsideration should be given to female education, poverty reduction and promotion of maternal healthcare services with particular attention to uneducated women or with low education levels, who reside in rural areas, women from poor household status and disparity in maternal health services across the provinces.
Mechanical interaction between the ground and a tibial prosthesis: a new characterisation protocol
Authors: Doyen Élodie , Szmytka Fabien , Semblat Jean-François 
Published: July 2022

Abstract
The study of Running Specific Prostheses (RSPs) is often limited to the blade. The setup developed and presented here is a simple experiment based on a testing machine and a camera that assesses two indicators relevant to coaches and athletes in the field of athletics: secant stiffness and energy dissipation. The influence of four parameters on global prosthesis behaviour was assessed: the load line adjustment, the prosthesis-ground angle, the sole type and the flooring type. The load line adjustment and the flooring type have little to no influence on their behaviour. The prosthesis-ground angle impacts the stiffness: an increase in angle brings a significant decrease in stiffness. The influence of the type of sole is harder to use for athletics since the practice of sport imposes the use of spikes. The camera images allow assessing the local behaviour of the sole, thus enabling to follow its strain through the compression process.
Prognostic impact of the number of metastatic lymph nodes after surgery in locally advanced hypopharyngeal cancer
Authors: Nishimura Ari , Yokota Tomoya , Hamauchi Satoshi , Onozawa Yusuke , Notsu Akifumi , Sato Fuyuki , Kawakami Takeshi , Ogawa Hirofumi , Onoe Tsuyoshi , Mukaigawa Takashi 
Published: July 2022

Abstract
Background
Postoperative chemoradiotherapy (CRT) is a standard therapy for patients with high-risk factors for head and neck squamous cell carcinoma, including incomplete resection and extra-nodal extension (ENE). However, the prognostic impact of the number of pathological metastatic lymph nodes (pLNs) in hypopharyngeal carcinoma (HPC) is unclear. Thus, this study aimed to investigate postoperative prognostic factors for locally advanced hypopharyngeal squamous cell carcinoma (LA-HPSCC) with a focus on the number of pLNs.
Methods
We retrospectively analyzed medical records of 99 consecutive patients with LA-HPSCC who underwent total pharyngo-laryngo-esophagectomy (TPLE) and bilateral neck dissection (ND) between December 2002 and May 2019.
Results
The median follow-up time for all censored patients was 63.2 months. The median overall survival was 101.0 months (95% confidence interval [CI] 48.1–134.9). Forty-five (45.5%) and 56 (56.5%) patients had pLNs < 3 and ≥ 3, respectively. Forty-six (45.5%) patients were diagnosed with ENE. Twenty (20.2%) patients received postoperative CRT and 79 (79.8%) did not. The multivariate analysis revealed that pLNs ≥ 3 (hazard ratio [HR] 2.39, 95% CI 1.16–4.94, p < 0.01) and ENE (HR 4.60, 95% CI 2.26–9.36, p < 0.01) were significantly associated with poor prognosis and that postoperative CRT (HR 0.34, 95% CI 0.16–0.72, p < 0.01) was significantly associated with better prognosis. The cumulative incidence of distant metastasis was higher in patients with pLNs ≥ 3 than in those with pLNs < 3 (p < 0.01).
Conclusions
pLNs ≥ 3 and ENE were significant poor prognostic factors for patients with LA-HPSCC who underwent TPLE and bilateral ND.
Exosomal miR-135a-5p promotes neovascularization via targeting SIRT1 in diabetic retinopathy
Authors: Li Yingxue , Fu Yan , Tong Yao , Zheng Yuanyuan , Yang Lu , Chen Yichen 
Published: July 2022

Abstract
Background: Diabetic retinopathy (DR) is one of the most serious microvascular complications of diabetes mellitus. Retinal neovascularization （RNV) under the continuous influence of hyperglycemia is the main cause of blindness in DR patients, but the mechanism of neovascularization has not been fully elucidated yet. In this study, we investigated the effect of exosomes secreted by human retinal pigmented epithelial (ARPE-19) cells at high glucose concentrations on in vitro angiogenesis of human umbilical vein endothelial cells(HUVECs). The role of exosomal miRNAs in the pathogenesis of DR was explored.Methods: Exosomes were extracted from the supernatant of ARPE-19 cells by differential centrifugation. Confocal microscopy was used to observe whether exosomes could be taken up by HUVEC, and the effects of exosomes on HUVEC angiogenesis under three sets of glucose concentrations were observed by co-culture and in vitro angiogenesis. The expression of 21 candidate miRNAsin exosomes and 22 candidate mRNAsin HUVEC after the effect of three sets of glucose concentrations was examined by qRT-PCR. Prediction of miRNA-targeted regulatory mRNAs by bioinformatics. Regulation of miR-135a-5p expression by transfection of small interfering RNA and miRNA mimic. Western blot and qRT-PCR were performed to detect the expression of SITR1.Results: Confocal images show that high glucose-induced exosomes （HG-exo） can be taken up by HUVECs and promote the tube formation of HUVECs in vitro. The results of qRT-PCR showed that the expressions of miR-9-3p, miR-135a-5p, miR-134-5p, miR-195-3p, miR-181c-5p and miR-132-3p were upregulated in HG-exo (P < 0.05). The expressions of HIF-1α, SIRT1 and SPRED1 in HUVECs co-cultured with HG-exo were decreased (P < 0.05). Bioinformatics analysis indicated that miR-135a-5p binds to the SIRT1 3'UTR region. We verified this by transfection experiments and showed that miR-135a-5p could inhibit the expression of SIRT1 mRNA and protein.Conclusions:In the presence of high glucose, exosomal miR135a-5p secreted by ARPE-19 cells targeted the SIRT1 3'UTR region and inhibited SIRT1 expression, which in turn promoted neovascularization.
Experimental studies of the thermophysical properties of the white earth stabilized with Portland cement used for building construction (Morocco)
Authors: Bakari Randa , Samaouali Abderrahim , Fertahi Saϊf Ed-Dîn , Ouaazizi Karima , Kanibou Fatima , Haddadi Soundous 
Published: July 2022

Abstract
The determination of the thermophysical properties of the building materials plays a vital role in buildings and industry field. Our choice is the white earth material which is currently experiencing a resurgence of interest regarding the energy and housing crisis. In contrast to cement, concrete or steel, white earth in its natural state can be used as a building material with practically no energy expenditure. It has many environmental, social and cultural advantages.
The aim of this work is to determine the thermal parameters of this material (thermal conductivity, volumetric heat capacity, specific heat, thermal diffusivity, effusivity and bulk density) at ambiant temperature of 20°C. The effect of compaction rate and the bulk density, on its properties, was evaluated. The measurements showed a significant increase in the thermal conductivity, the volumetric heat capacity, the diffusivity and the thermal effusivity as a function of compaction. The significant influence of the bulk density on the thermal conductivity was shown. The addition of cement to the initial material (white earth) decreases the thermo-physical properties for low percentages. As the percentage of cement incorporated increases, its thermal parameters increase significantly.
Differential characteristics among asymptomatic and symptomatic meibomian gland dysfunction and those with dry eye
Authors: Chiou Yi-Ran , Lin Pei-Yu , Chou Yu-Bai , Huang Po-Wei , Fan Nai-Wen 
Published: July 2022

Abstract
Purpose: To identify the characteristics of asymptomatic meibomian gland dysfunction (MGD), symptomatic MGD, and MGD coexisting with dry eye disease (DED). Methods: This cross sectional study enrolled a total of 153 eyes of 87 MGD patients. Participants filled in ocular surface disease index (OSDI) questionnaires. Age, gender, Schirmer’s test, meibomian gland (MG) related parameters, lipid layer thickness (LLT) and blinking were compared among patients with asymptomatic MGD, symptomatic MGD, and MGD with DED. Multivariate regression was used to analyze the significant factor of DED in MGD. Linear regression analysis was used to evaluate the association between the significant factors and MG function. Results: There was no difference in age, Schirmer’s test, lid changes, MG secretion, and MG morphology among three groups. Patients with MGD coexisting with DED exhibited more frequent eye blinking than that of patients with asymptomatic MGD (P = 0.022), and reduced LLT than that of patients with asymptomatic MGD (P = 0.010) and symptomatic MGD (P = 0.015). Multivariate analysis identified LLT (OR, 0.97) as a significant factor associated with DED development in MGD. The number of expressible MG was positively correlated with LLT (P = 0.016) but negatively correlated with the number of blinking (P = 0.016) in MGD patients with DED, and these findings were not identified in those without DED.Conclusions: Asymptomatic MGD, symptomatic MGD, and MGD coexisting with DED share similar characteristics, including meibum secretion and morphology, but MGD patients coexisting with DED exhibited signifcantly reduced LLT.
Undercutting transit? Exploring potential competition between automated vehicles and public transportation in the U.S.
Authors: Kaplan Leah , Helveston John Paul 
Published: July 2022

Abstract
Automated vehicles (AVs) have the potential to dramatically disrupt current transportation patterns and practices. One particular area of concern is AVs’ impacts on public transit systems. If vehicle automation enables significant price decreases or performance improvements for ride-hailing services, some fear that it could undercut public transit, which could have important implications for the environment and transportation equity. The extent to which individuals adopt automated transportation modes will drive many system-level outcomes, and research on public preferences for AVs is immature and inconclusive. In this study, we use responses from an online choice-based conjoint survey fielded in the Washington, D.C. Metropolitan Region (N = 1,736) in October 2021 to estimate discrete choice models of public preferences for different automated (ride-hailing, shared ride-hailing, bus) and non-automated (ride-hailing, shared ride-hailing, bus, rail) modes. We use the estimated models to simulate future marketplace competition across a range of trip scenarios. Respondents on average were only willing to pay a premium for automated modes when a vehicle attendant was also present, limiting the potential cost savings that AV operators might achieve by removing the driver. Additionally, scenario analysis revealed that for trips where good transit options were available, transit remained competitive with automated ride-hailing modes. These results suggest that fears of a mass transition away from transit to AVs may be limited by people’s willingness to use AVs, at least in the short term. Future AV operators should also recognize presence of an AV attendant as a critical feature for early AV adoption.
Prevalence and global trends of polypharmacy in patients with chronic Liver disease: a systematic review and meta-analysis
Authors: danjuma mohammed , ansari soubiya , AlShibly Rafal Jamal , Elhams mohammed , Alshamri Manwa , Naseralalah Lina Mohamed 
Published: July 2022

Abstract
Background
despite its central role in drug metabolism the exact prevalence estimates and factors impacting on the global trends of polypharmacy in patients with chronic liver disease has remained unexamined.
Methods
We carried a comprehensive search of relevant databases (PubMed; EMBASE, Science citation index Cochrane Database of Systematic Reviews; and database of abstracts of reviews of effectiveness for studies since inception to and 30th May 2022 that reported on patients with chronic liver disease for which data on the prevalence estimates of polypharmacy (ingestion of > 5 non-ART was available. We subsequently carried out a systematic review and weighted meta-analysis to ascertain the exact prevalence of polypharmacy amongst patients with chronic liver disease. We evaluated the heterogeneity between studies with \({I}^{2}\) and \({\tau }^{2}\) statistics.
Results
Fifty studies were identified from initial literature, out of which 7 (enrolling N = 521435 patients with Chronic Liver Disease met the inclusion criteria; of this 58.7% were males, with mean age of 53.9 (± 12.2) years. The overall pooled prevalence of polypharmacy amongst patients with chronic liver disease was 31% (95% CI: 4% − 66%) (I2 = 100%, τ2 = < 0.001, p = < 0.0001). we found a higher pooled prevalence estimates amongst patients aged 50 years and older compared to their younger cohorts (42%, [CI 10–77]; I2 = 100%, P = < 0.001 vs. 21%, [CI 0–70]; I2 = 100%, P = < 0.001).
Conclusion
In an examination of multiple community and hospital-based databases of patients with chronic liver disease, we found a pooled prevalence estimate of polypharmacy at about 31%. This represents a case burden within the range reported in the general population and will respond to mitigation strategies thus far employed for patients in that population.
Research of food security in Xiamen under the background of arable land loss and COVID-19 pandemic
Authors: Zhang Tianhai 
Published: July 2022

Abstract
The outbreak and spreading of the COVID-19 pandemic worldwide slowed down the agricultural and industrial production. Related lockdown or restriction caused problems in logistics and food supply globally, resulted in rising of food prices worldwide and threats to food security. China got through long period of rapid urbanization in period of 1990–2020, and large number of arable land has been occupied as built-up land. This situation brought potential food security threats, such as food supply reduction, food self-sufficiency difficulties in special regions, special period. This research takes Xiamen, a coastal city with rapid urbanization in China, as the research area, analyzed its dynamic changes of land use and per capita crops production for years. In addition, food availability like the import with export also got analyzed, as well as food price under the background of COVID-19 pandemic. The results show that the increase of built-up land in Xiamen is the largest, followed by decrease of arable land. Large proportion of arable land has been converted into built-up land from 1989 to 2018. The decrease of arable land and increase of population due to rapid urbanization lead to the decrease of per capita crops production to 6kg in 2018, which is only 1% of China’s average level. By comparison of per capita crops production in different regions and the change of China’s crops import and export, it is found that there is a significant contradiction between the urbanization ratio and food security in Xiamen, and it is difficult for Xiamen to obtain food input from regions nearby for long-term. Especially, not only the global food price index but also the food price in whole China continue rise up during period of COVID-19 pandemic right now. Thus, Xiamen needs to take multiple measures and policy interventions to ensure a certain degree of food self-sufficiency, and protect the basic arable land as well.
A comparison of experience sampled hay fever symptom severity across rural and urban areas of the UK
Authors: Gledson Ann , Lowe Douglas , Reani Manuele , Topping David , Hall Ian , Cruickshank Sheena , Harwood Adrian , Woodcock Joshua , Jay Caroline 
Published: July 2022

Abstract
Hay fever affects people differently and can change over a lifetime, but data is lacking on how environmental factors may influence this. This study is the first to combine atmospheric sensor data with real-time, geo-positioned hay fever symptom reports to examine the relationship between symptom severity and air quality, weather and land use. We study 36145 symptom reports submitted over 5 years by over 700 UK residents using a mobile application. Scores were recorded for nose, eyes and breathing. Symptom reports are labelled as urban or rural using land-use data from the UK’s Office for National Statistics. Reports are compared with AURN network pollution measurements and pollen and meteorological data taken from the UK Met Office. Our analysis suggests urban areas record significantly higher symptom severity for all years except 2017. Rural areas do not record significantly higher symptom severity in any year. Additionally, symptom severity correlates with more air quality markers in urban areas than rural areas, indicating that differences in allergy symptoms may be due to variation in the levels of pollutants, pollen counts and seasonality across land-use types. The results provide evidence that urban surroundings may exacerbate hay fever symptoms.