bluuebunny/crossref_metadata_2025_split huggingface dataset:
Praktik Reksadana Online Syariah pada Aplikasi Bibit dalam Tinjauan Hukum Islam
Authors: Maulana Diky Faqih , Rozak Abdul 
Published: February 2022

Penelitian ini bertujuan untuk menganalisis praktik reksadana online syariah pada aplikasi Bibit dalam tinjauan hukum Islam. Penelitian ini bersifat deskriptif analisis dengan pendekatan normatif yang mendasarkan nash dan ijtihad para ulama sebagai upaya pemberian norma terhadap objek penelitian. Hasil penelitian menunjukkan bahwa secara keseluruhan, praktik reksadana online syariah pada aplikasi Bibit sudah sama dengan DSN Nomor 20/DSN-MUI/IV/2001 tentang pedoman pelaksanaan investasi untuk reksadana syariah. Dilihat dari fikih muamalat, juga telah memenuhi unsur dan syarat akad berupa para pihak, ijab dan kabul, objek akad dan tujuan akad. Transaksi dalam Bibit telah memenuhi beberapa asas akad seperti prinsip kesamaan (mabda’ at-tawazun fi a-mu’awadah), prinsip kebaikan dan prinsip dapat dipercaya. Adanya pengawasan oleh Dewan Pengawas Syariah dalam sistem tata kelola syariah (shariah governance) dan OJK yang mengevaluasi setiap 6 bulan terhadap Daftar Efek Syariah. Batasan Bibit terhadap maksimal rasio utang aset perusahaan sebesar 45%, penerapan prinsip Socially Responsible Investment (SRI), gratis biaya transfer, gratis biaya komisi, bebas pajak, bisa menambah atau mencairkan dana kapan saja merupakan suatu implementasi maqashid as-syariah. Namun perlu dievaluasi kembali terkait bank kustodian yang masih memakai bank konvensional atau non syariah. [This study aims to analyze the practice of sharia online mutual funds in the Bibit application in Islamic law review. This research is a descriptive analysis with a normative approach based on the texts and ijtihad of the Ulama as an effort to give norms to the object of research. The results showed that overall, the practice of sharia online mutual funds in Bibit application was in accordance with the DSN Fatwa Number 20/DSN-MUI/IV/2001 regarding the guidelines for implementing investments for Islamic mutual funds. Judging from the muamalat fiqh, it has also fulfilled the elements and conditions of the contract in the form of the parties, agreement , the object of the contract and the purpose of the contract. Transactions in Bibit have fulfilled several contractual principles such as the principle of balance (mabda' at-tawazun fi a-mu'awadah), the principle of benefit and the principle of mandate. There is supervision by the Sharia Supervisory Board in the sharia governance system and OJK which evaluates every 6 months the Sharia Securities List. The limit of seeds to the maximum debt ratio of company assets is 45%, the application of the principles of Socially Responsible Investment (SRI), free transfer fees, free commission fees, tax free, being able to add or withdraw funds at any time is an implementation of maqashid as-sharia. However, it needs to be re-evaluated regarding custodian banks that still use conventional or non-Islamic banks.]
Comparable Short- And Intermediate-Term Outcomes In Recipients of Single Kidney Transplants From Small Vs. Big Pediatric Donors
Authors: Liao Zhanchen , Jiang Tao , Liu Yiqi , Luo Zhigang 
Published: February 2022

Abstract
Purpose: To optimize the use of Single kidney transplantation (SKT) and evaluate outcomes in recipients of single kidney transplants from small pediatric donors, compared to big pediatric donors.Methods: A total of 85 SKTs from pediatric donors (≤18 years-old) were performed in our hospital between 2015 and 2020. Outcomes were compared for recipients of small donors (≤8 years-old; small-kidney group [SKG], n = 38) and big donors (9–18 years-old; big-kidney group [BKG], n = 47). Results: The SKG and BKG had no significant differences in patient survival at 1 year (100% vs. 100%), 3 years (100% vs. 97.0%), and 5 years (100% vs. 97.0%) and in graft survival at 1 year (97.4% vs. 97.9%), 3 years (92.9% vs. 94.9%), and 5 years (92.9% vs. 94.9%). The 5-year death-censored graft survival was 100% in the SKG and 97.9% in the BKG. The rate of transplant renal artery stenosis (TRAS) was significantly greater in the SKG than the BKG (18.4% vs. 4.3%, P = 0.039).Conclusion: The clinical outcomes achieved by performing SKT from small pediatric donors are comparable to those achieved for SKT from big pediatric donors. These results support the use of SKT from young pediatric donors.Trial registration: (ClinicalTrials, gov number: ChiCTR2100044055)
Direct Measurement of Nonadditive van der Waals Forces From Graphene Nanostacks
Authors: Tkatchenko Alexandre , Gordiichuk Pavlo , Ambrosetti Alberto , Strano Michael 
Published: February 2022

Abstract
Theoretical evidence suggests strong nonadditivity of van der Waals (vdW) forces at the nanoscale(1,2), but direct experimental confirmation is missing(3). By aligning the underlying surface sample with a macroscopic tipless Si cantilever, we present essentially noise-free vdW force measurements up to micrometer separations from multilayered graphene (MLG) nanostacks of variable thickness (1-21 layers) adsorbed on SiO2 as well as from macroscopically-thick highly ordered pyrolytic graphite (HOPG). At contact cantilever-surface separation, the vdW force increases non-additively but monotonically from graphene to HOPG. Conversely, at separations D>100 nm the vdW forces from MLG exhibit tunable power laws and the magnitude of the force on top of thick MLG nanostacks substantially exceeds the force measured on top of HOPG, despite the latter showing a slower decaying power law (D^-4 for MLG vs D^-3 for HOPG). Such a strong nonadditivity and tunable power laws of vdW forces at the nanoscale are rationalized by many-body calculations that include the nonlocal polarization response in graphene nanostacks.
The Direct Cost of Dialysis in Patients With Chronic Renal Failure in Ouagadougou (Burkina Faso) in 2020
Authors: Touré Amadou Oury , Baldé Mamadou Dioulde , Diallo Aissatou , Camara Sadan , Soumah Anne Marie , Sall Alpha Oumar , Kourouma Karifa , Camara Bienvenu Salim , Bocoum Fadima Yaya , Kouanda Seni 
Published: February 2022

Abstract
Background: Chronic renal failure is a serious pathology requiring renal dialysis. The number of patients under dialysis has increased considerably in the world and particularly in sub-Saharan Africa. Dialysis is a very expensive care. This is the reason why this study on the costs of dialysis management was initiated in Burkina Faso. The study objective is to determine the direct medical and non-medical costs of managing chronic renal failure among patients undergoing dialysis in Ouagadougou in 2020.Methods: An analytical cross-sectional study was conducted. Data were collected in the hemodialysis department of three public university hospitals in Ouagadougou, Burkina Faso. All dialysis patients with chronic renal failure were included in the study. Linear regression was used to investigate the determinants of the direct medical and non-medical cost of hemodialysis. Results: A total of 290 patients participated in this study, including children, adults, and the elderly with extremes of 12 and 82 years. Almost half of the patients (47.5%) had no income. The average monthly total direct cost across all patients was 75842 CFA or US$134.41.The average direct medical cost was 51315 CFA or US$90.94 and the average direct non-medical cost was 24 527 CFA or US$43.47. Most of the patients (45.2%) funded their hemodialysis by their own source. The multivariate analysis showed that the presence of an accompanying person during treatment, residing in a rural area, ambulatory care, use of personal cars, and treatment at the dialysis center of Yalgado Teaching Hospital were associated with higher direct costs.Conclusion: The average cost of dialysis services borne by the patient and his/her family is very high in Burkina Faso since itis 2.1 times higher than the inter-professional minimum wage in the country (34664 CFA or 61.4 $US). It appears that the precariousness of the means of subsistence strongly increases with the occurrence of chronic renal failure requiring dialysis. Thus, to alleviate the expenses borne by patients undergoing dialysis, it would be important to extend the state subsidy package to the costs of drugs and to promote health insurance to ensure equitable care for these patients.
Clinical evaluation of a new rapid fingerstick point-of-care microfluidic immunofluorescence assay for the detection of SARS-CoV-2 antibodies: A prospective evaluation study
Authors: Ellis Jayne E. , Morgan Matthew , Simon William , Lawson Vicki , Lindner Nigel M. 
Published: February 2022

Abstract
Introduction: The LumiraDx SARS-CoV-2 Antibody (Ab) Test is a point-of-care (POC) test that can use fingerstick samples in a rapid, high-sensitivity microfluidic immunofl­uorescence assay to qualitatively detect total antibodies to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The test was evaluated for clinical agreement using samples with lab-based antibody detection systems and real-time polymerase chain reaction (RT-PCR)-confirmed SARS-CoV-2 infection status across POC settings.Methods: Plasma samples from participants (≥18 years) were collected from clinical studies and commercial suppliers for positive and negative agreement analysis using the Abbott ARCHITECT SARS-CoV-2 IgG and RT-PCR as reference tests. Fingerstick application with capillary blood (applied directly or using transfer tube) from participants (≥18 years) was analysed following RT-PCR testing and evaluated against Abbott ARCHITECT SARS-CoV-2 IgG, Elecsys Anti-SARS-CoV-2 and RT-PCR test results. Cross-reactivity was analysed using samples with known related and high-prevalence pathogens. Application was performed by untrained users and ease of use of the LumiraDx SARS-CoV-2 Ab Test was investigated.Results: A positive agreement of 100% (95% confidence interval [CI]: 92.9, 100%; n=50) was determined in comparison with the Abbott ARCHITECT SARS-CoV-2 IgG test results and 97.2% (95% CI: 90.4, 99.2%; n=72) with RT-PCR, in samples obtained ≤118 days following RT-PCR testing. In participants without a history of SARS-CoV-2 infection, 100% (95% CI: 94.5, 100%; n=66) negative agreement was established when evaluated against the Abbott ARCHITECT SARS-CoV-2 IgG test and 100% (95% CI: 98.7, 100%; n=290) against RT-PCR testing. There was 100% agreement observed between capillary fingerstick application and Abbott ARCHITECT SARS-CoV-2 IgG, Elecsys Anti-SARS-CoV-2 or RT-PCR results, as well as between sample application methods. There was no notable cross-reactivity with any of the tested pathogens and test operators indicated that the LumiraDx SARS-CoV-2 Ab Test was easy to use. Conclusion: The LumiraDx SARS-CoV-2 Ab Test demonstrated excellent agreement when compared with lab-based antibody detection systems and RT-PCR test results, using capillary whole blood and plasma.
Molecular Architecture of PSMα1 Functional Amyloids
Authors: Elvati Paolo , Luyet Chloe , Wang Yichun , Liu Changjiang , VanEpps J , Kotov Nicholas , Violi Angela 
Published: February 2022

Abstract
Biofilms are structurally and functionally complex networks of bacteria and nanoscale macromolecules that play an important role in a myriad of settings from personal health and agriculture to power productions and fuel storage. Amyloid nanofibers are integral components of many biofilms and serve various purposes ranging from virulent to structural. Nonetheless, the precise characterization of bacterial amyloid nanofibers has been elusive, with incomplete and contradicting results. The present work focuses on the molecular details and characteristics of PSMα1 derived functional amyloids present in Staphylococcus aureus biofilms, using a combination of computational and experimental techniques. Results from molecular dynamics simulations, guided and supported by a variety of experiments, show that nanoscale nanofibers present a helical structure formed by two-protofilament PSMα1 amyloid nanofibers. PSMα1 peptides assembles into cross-β
sheet structures with an average diameter of about 12 nm, adopting a left-handed helical structure with a periodicity of approximately 72 nm. Strikingly, the chirality of the self assembled nanofibers, an intrinsic geometric property of its constituent peptides, is central in determining the growth and shape of the fibers. The presented findings provide structural insights into the properties of the functional amyloids, hypothesize the role of chirality on the formation of fibers, and aid in strategies for the design of anti-amyloid compounds.
Multisensory GPS impact on spatial representation in an immersive virtual reality driving game
Authors: Seminati Laura , Hadnett-Hunter Jacob , Joiner Richard , Petrini Karin 
Published: February 2022

Abstract
Individuals are increasingly relying on GPS devices to orient and find their way in their environment and research has pointed to a negative impact of navigational systems on spatial memory. We used immersive virtual reality to examine whether an audio-visual navigational aid can counteract the negative impact of visual only or auditory only GPS systems. We also examined the effect of spatial representation preferences and abilities when using different GPS systems. Thirty-four participants completed an IVR driving game including 4 GPS conditions (No GPS; audio GPS; visual GPS; audio-visual GPS). After driving one of the routes in one of the 4 GPS conditions, participants were asked to drive to a target landmark they had previously encountered. The audio-visual GPS condition returned more accurate performance than the visual and no GPS condition. General orientation ability predicted the distance to the target landmark for the visual and the audio-visual GPS conditions, while landmark preference predicted performance in the audio GPS condition. Finally, the variability in end distance to the target landmark was significantly reduced in the audio-visual GPS condition when compared to the visual and audio GPS conditions. These findings support theories of spatial cognition and inform the optimisation of GPS designs.
Feasibility of COVID-19 control from a pandemic to endemic
Authors: Chen Tianmu , Zhao Zeyu , Niu Yan , Chu Meijie , Rui Jia , Wang Yao , Hu Shixiong , Luo Kaiwei , Deng Yan-qin , Ye Wen-Jing , Guo Zhinan , Su Yanhua , Zhao Ben-hua 
Published: February 2022

Abstract
Evaluations of the pandemic to endemic phase are a great concern, especially in Zero-COVID-19 countries. Herein, we developed a mathematical model to simulate future scenarios for the variants of concern (VOCs) in the condition of several immune barriers and controlling measures. The results demonstrated that the Omicron variant would lead to 592.0 (mean ± standard deviation (SD): 433.9–750.0) million symptomatic, 24.3 (mean ± SD: 17.4–312.8) million hospital admission, 9.6 (mean ± SD:7.0–12.3) million ICU admission, and 5.4 (mean ± SD:3.7–7.5) million death cases after simulation with 1,000 days. At the endemic phase, there were nearly 500 death cases per day attributed to reinfection (66% [range: 62–70%]), infection from birth (18% [range: 16–21%]), and infection from migration (16% [range: 14–17%]). Actively treating more than 80% of cases could effectively reduce disease severity and death rates. It is feasible to transmit pandemic to endemic with Omicron variant and other milder VOCs. We recommend that the successful transition strategy is to improve medical resource allocation and enhance the prevention and control capabilities of health agencies.
Neuro Protective Effect of Baicalein Against Oxaliplatin-Induced Peripheral Neuropathy: Impact on Oxidative Stress, Neuro-inflammation and WNT/β-Catenin Signaling
Authors: Jugait Simrandeep , Areti Aparna , Nellaiappan Karthika , Narwani Priyanka , Saha Priya , Velayutham Ravichandiran , Kumar Ashutosh 
Published: February 2022

Abstract
Oxaliplatin, an effective anti-cancer agent used in the treatment of colorectal cancer, associated with severe dose limiting side effect peripheral neuropathy, which currently remains a major unmet clinical need. This study was designed to investigate the possible neuroprotective potential of a bioflavonoid, Baicalein in an experimental model of oxaliplatin induced peripheral neuropathy. Rats were administered with a dose of 4 mg/kg oxaliplatin i.p. twice per week for four weeks and they were evaluated for behavioural and functional nerve parameters, followed by bio-chemical, immunohistochemical and western blot analysis. Results from this study show that baicalein reversed oxaliplatin-induced behavioural deficits and significantly prevented oxaliplatin-induced sensory nerve conduction deficits in rats. Molecular analysis revealed baicalein significantly strengthened the antioxidant defense system by enhancing the expression of MnSOD, HO-1 and GSH levels. Baicalein treatment neutralized the oxaliplatin-induced neuroinflammation which was evident from the significant loss of inflammatory mediators like TNF-α, IL-6 and a shunted NF-κB nuclear translocation. Additionally, Baicalein treatment resulted in a significant downregulation of active β-catenin, Wnt5b and Wnt3a proteins. In line with the in vivo evidences, treatment of baicalein in Neuro2a cells showed suppression of oxaliplatin induced ROS, mitochondrial superoxide levels and improved neuritogenesis against oxaliplatin-induced toxicity in Neuro2a cells. Additionally, Baicalein did not alter the cell viability of oxaliplatin in HCT-116 cell line. Collectively, these characteristics suggest that baicalein may be useful in the clinical management of peripheral neuropathy associated with oxaliplatin.
Detecting Multiscale Periodicity From the Secular Effusive Activity at Santiaguito Lava Dome Complex (Guatemala)
Authors: Massaro Silvia , Costa Antonio , Sulpizio Roberto , Coppola Diego , Soloviev Anatoly 
Published: February 2022

Abstract
Santiaguito, Guatemala, represents one of the best cases of active lava dome complex in the world, producing lava flow effusion, weak explosive activity, and cycles of lava dome extrusion over varying timescales. Since the inception in 1922, it has shown a remarkable constant eruptive activity, characterized by effusion of blocky domes and lava flows punctuated by moderate explosions of gas-and-ash and pyroclastic flows. In this study, we reconstruct the time evolution of discharge rates of Santiaguito across one entire century, from 1922 to 2021, combining, for the more recent activity, new satellite thermal data. By using Discrete Fourier Transform (DFT) and Morlet wavelet analyses we identify three fundamental periodicities in subsets of the 1922-2021 time series: (i) long-term (ca. 10 years), (ii) intermediate-term (ca. 3.5 years), and (iii) short-term (from ca. 1 year to ca. 3 months), which are comparable with those observed at other lava dome eruptions at calc-alkaline volcanoes. Such inferred periodicities provide a powerful tool for the interpretation of the non-linear eruptive behaviour and represent a pivotal benchmark for numerical modelling aimed to reconstruct the dynamics of the magma feeding system based on a time-averaged discharge rate dataset.
A one-dimensional parameter-free model for carcinogenesis in gene expression space
Authors: Leon Dario A. , Herrero Roberto , Gonzalez Augusto 
Published: February 2022

Abstract
A small portion of a tissue defines a microstate in gene expression space. Mutations, epigenetic events or external factors cause microstate displacements which are modeled by combining small independent gene expression variations and large Levy jumps, resulting from the collective variations of a set of genes. The risk of cancer in a tissue is estimated as the microstate probability to transit from the normal to the tumor region in gene expression space. The formula coming from the contribution of large Levy jumps seems to provide a qualitatively correct description of the lifetime risk of cancer in 8 tissues, and reveals an interesting connection between the risk and the way the tissue is protected against infections.
Inflammation suppresses DLG2 expression, preventing inflammasome formation
Authors: Keane Simon , Herring Matthew , Rolny Peter , Wettergren Yvonne , Ejeskär Katarina 
Published: February 2022

Abstract
PurposeLoss of expression of DLG2 has been identified in a number of cancers to contribute to the disease by resulting in increased tumor cell proliferation and poor survival. In light of the previous evidence that DLG2 alters the cell cycle and affects proliferation, combined with indications that DLG2 is involved in NLRP3 inflammasome axis we speculated that DLG2 has an immune function. So far, there is no data that clearly elucidates this role, and this study was designed to investigate DLG2 in inflammatory colon disease and in colon cancer as well as its impact on inflammasome induction.MethodsThe DLG2 expression levels were established in publicly available inflammation, colon cancer and mouse model datasets. The overexpression and silencing of DLG2 in colon cancer cells were used to determine the effect of DLG2 expression on the activation of the inflammasome and subsequent cytokine release.ResultsDLG2 overexpression leads to a significant increase in the formation of inflammasomes with lower release of IL-6, fewer proliferating cells and fewer cells in G2/M phase. Silencing of DLG2 impaired inflammasome formation. Additionally, DLG2 overexpression increased the expression of the NF-kappa-B inhibitor NFKBIZ.ConclusionDLG2 expression is altered in response to inflammation in the gut as well as in colon cancer, resulting in altered ability to form inflammasomes and cytokine release.Trial registration: NCT03072641
The Effect of Ply Properties in Paperboard Converting Operations: A Way To Increase Formability
Authors: Lindberg Gustav , Kulachenko Artem 
Published: February 2022

Abstract
This study addresses the question of how the difference in mechanical properties of the individual layers in a multiply commercial paperboard affects the outcome of the tray-forming operation. Two commercially produced paperboards with nearly identical mechanical properties when conventionally tensile tested were considered. These boards are produced on different machines with the same target grammage and density. Despite the similar mechanical properties, their performance in a given tray-forming operation was drastically different, with one of the boards showing an unacceptable failure rate. To investigate the difference seen during converting operations, a detailed multi-ply finite element model was built to simulate the converting operation. The present model considers a critical area of the paperboard known to exhibit failures. To derive the constitutive relations for each ply in the sub-model, both boards were split to single out individual plies which were then tensile tested. Including the properties of individual plies revealed large differences between the boards when it comes to the distribution of the properties in the thickness direction. In particular, the top plies differed to a large extent. This is attributed to the difference in refining energies for the plies. The results from the three-ply sub-model demonstrated the importance of including the multiply structure in the analysis. Weakening of the top ply facing the punch by using lower refining energy considerably increased the risk of failure of the entire board. These results suggest that there is room for optimizing the board performance by adjusting the refining energy at the ply level.