bluuebunny/crossref_metadata_2025_split huggingface dataset:
LBODP047 Correlation Of Insulin Resistance And Short-term Outcome In Non-diabetic Patients With St Segment Elevation Myocardial Infarction
Authors: Al-Ali Saja , Alidrisi Haider Ayad , Abdulhameed Abdulameer 
Published: November 2022

Abstract

Background
Obviously, hyperglycemia and insulin resistance (IR) are common in patients with ST-segment elevation myocardial infarction (STEMI) in the hospital, and they are connected to poor clinical outcomes. Additionally, insulin resistance is a substantial risk factor for cardiovascular diseases. The case of acute myocardial infarction likewise has a bleak prognosis. The study aimed to evaluate the association between IR and short-term outcomes of acute STEMI patients without diabetes mellitus in the form of reperfusion success, the occurrence of heart failure, development of arrhythmias, and mortality. Method: A cross-sectional study was done from August 2021 to December 2021 in two cardiology centers in Al-Sadr teaching hospital and Basrah oil hospital in Basrah, southern Iraq. Sixty-one nondiabetic hospitalized patients with acute STEMI were included in the study. Clinical data were collected by direct interview with the patients, 25(41%) of them received thrombolytics and 36 (59%) were managed with percutaneous transluminal coronary angioplasty. From each patient, a fasting blood sample was taken for glucose, triglyceride, and insulin to measure IR in the form of the homeostasis model assessment for IR (HOMA-IR) and triglyceride glucose index (TyG index). Both measures were grouped into three tertiles, for HOMA-IR (tertile 1 &lt; 2.5, tertile 2 2.5 - &lt;5, and tertile 3 ≥5) and for TyG index (tertile 1 &lt;4.73, tertile 2 4.73 - &lt;4.87, and tertile 3 ≥4.87). The patients were evaluated within 1-week for (reperfusion success, echocardiography for calculation of the ejection fraction (EF), arrhythmias, and mortality), and within 4-weeks for mortality.

Results
Within the tertile 3 of HOMA-IR, the patients were significantly more likely to have EF &lt; 55% (35%), and higher 4-weeks mortality (35%). Also for the TyG index and within the tertile 3 (≥ 4.87), there was a significantly higher 4-weeks mortality (30%). Pearson correlation also showed significant and negative correlations between both HOMA-IR and TyG index values and EF. While reperfusion success, arrhythmias, and 1-week mortality did not correlate significantly with both HOMA-IR and TyG index.

Conclusion
Insulin resistance as defined by HOMA-IR and TyG index was significantly associated with poor outcomes in patients with acute STEMI in the form of EF&lt;55 and 4-weeks mortality.
Presentation: No date and time listed
LBODP049 Clinical And Biochemical Markers In Early Pregnancy For Prediction Of Gestational Diabetes Mellitus
Authors: Manglunia Ankit , Kanwar Jaya Bhanu , Mangaraj Swayamsidha , Swain Jayashree , Sahoo Abhay Kumar , Sahoo Manisha , Pati Tapasi , Mishra Sujata , Pattnaik Tapan , Das Sasmita , Ray Subhashree , Panigrahy Rajashree , Gochhait Samanyoya 
Published: November 2022

Abstract

Background
Early identification of Gestational Diabetes Mellitus (GDM) is pivotal to reduce feto-maternal complications associated with the disease. Current risk prediction models that are based on maternal clinical and biochemical parameters lack a strong predictive value.

Objective
To evaluate the early trimester maternal parameters for prediction of gestational diabetes mellitus.

Methods
In this prospective observational study, we screened 581 consecutive healthy women with singleton pregnancy for GDM during their first antenatal visit. After informed consent, fasting blood samples were collected and stored at -800C. GDM was diagnosed as per IADPSG criteria. During prospective follow up, total 55 patients developed GDM. A total of 110 age and BMI matched controls were recruited for comparison. In all women, we measured Oral Glucose Tolerance test (OGTT) with 75 gm anhydrous glucose, fasting insulin, HbA1c, hsCRP, uric acid and Lipid Profile. HOMA-IR, HOMA-β and QUICKI were used to evaluate insulin sensitivity and β-cell function.

Results
Significant higher proportion of subjects in GDM cohort had presence of acanthosis nigricans and positive family history of Type 2 Diabetes Mellitus in first degree relative. The GDM cohort had significantly higher median waist circumference, 2hr plasma glucose (2hr PPG), HbA1c, fasting insulin, HOMA-IR, uric acid and serum triglyceride levels. The receiver operating characteristic (ROC) curve were as follows: HbA1c - 0.74 (95%CI: 0.661–0.819), Fasting Insulin - 0.748 (95%CI: 0.671–0.826), high sensitivity C-Reactive Protein (hsCRP) - 0.689 (95%CI: 0.605 - 0.773) and Uric acid - 0.718 (95%CI: 0.635–0.802). Multiple regression analysis revealed HbA1c (OR 5.264; p=0. 007), 2hr PPG (OR 1. 026; p=0. 035), QUIKI (OR 1. 057; p=0. 016), uric acid (OR 1. 039; p=0. 013) and neutrophil: lymphocyte ratio (OR 1.545; p=1. 008) to be independently associated with GDM outcome with combined area under the curve (AUC) of 0.850, a sensitivity of 72.7% and a specificity of 87.3%.

Conclusions
Fasting Insulin, HbA1c, HOMA-IR, hsCRP and Uric acid levels are significantly increased in early pregnancy in individuals who develop GDM subsequently, compared to women who did not develop GDM. Hence utilization of these parameters may identify at risk group in routine clinical care and help in improving feto-maternal outcome.
Presentation: No date and time listed
LBODP050 Examination Of The Effectiveness Of Diabetic Nephropathy Treatment Targeting Chrebp Activity
Authors: Suzuki Susumu , Yokoyama Atsushi , Sugawara Akira , Okamoto Koji , Iwabuchi Yoshiharu 
Published: November 2022

Abstract
Diabetic nephropathy (DN) is the main cause of chronic kidney disease (CKD) and is characterized by elevated urinary albumin to creatinine ratio (UACR) and serum creatinine, and decreased glomerular filtration rate. Anti hypertensive agents are used for DN treatment, however, the effects of these drugs are insufficient, and the establishment of more effective treatment methods is desired. Carbohydrate responsive element binding protein (ChREBP) is one of the factors reported to be involved in the onset and progression of DN (1). Furthermore, whole body ablation of ChREBP suggested that the progression of DN was suppressed in the rodent model (2). On the other hand, the effectiveness of pharmaceutical ChREBP suppression is unclear, thus, we performed administration experiment to DN model mice using ChREBP activity inhibitor and examined the effects of pharmaceutical ChREBP activity suppression on renal function of diabetic mice. First, we established high-throughput screening system capable of detecting ChREBP activity and performed screening of Tohoku university compound library. The result compound, D-532, was ChREBP activity specific inhibitor without cell toxicity. D-532 directly binds to DNA-binding domain of ChREBP, and inhibits the transcriptional activity. We next performed administration experiment using type I DN model mice. D-532 treatment group showed an improvement tendency of the low body weight compared with that of vehicle treatment group, while it had no effect on blood glucose level. About renal functions, both of UACR and serum creatinine were significantly lower in D-532 treatment group. Importantly, renal tissues such as glomeruli and renal tubules were preserved in D-532 treatment group compared with in vehicle treatment group. In vivo as well, D-532 suppressed ChREBP target genes mRNA expression, and RNA-seq analysis with mice renal cortex RNA at the end of D-532 administration experiment indicated that D-532 suppressed excessive oxidative stress through the ChREBP activation under diabetes. These results indicate that ChREBP suppression is effective on DN rodent model, and ChREBP activity inhibitor D-532 may have potential as a new treatment for DN in the future. Reference: (1) Suzuki et al., Endocr J. 2019 Mar 28;67(3): 335-345. (2) Zhang et al., Eur Rev Med Pharmacol Sci. 2017 Jan;21(1): 42-47.
Presentation: No date and time listed
LBODP052 A Novel Hnf4α Corepressor Irf2bp2: Its Role In The Gluconeogenic Gene Regulation Via Biochemically Labile Interaction
Authors: Kouketsu Takumi , Sugawara Akira , Yokoyama Atsushi , Igarashi Kazuhiko , Shima Hiroki , Sawatsubashi Shun 
Published: November 2022

Abstract
Hepatocyte nuclear factor 4α (HNF4α) has an essential role in controlling the expression of variety of genes involved in key metabolic pathways including gluconeogenesis in the liver. Though mechanistic and physiological significance of proliferator-activated receptor-gamma co-activator-1α (PGC-1α) for HNF4α-mediated transcriptional activation models for gluconeogenic genes is well characterized, transcriptional repression of HNF4α for those genes still remains to be examined. In this study, we applied novel proteomic techniques to evaluate the HNF4α interactome including biochemically labile binding proteins. From the experiment, we identified interferon regulatory factor 2 binding protein 2 (IRF2BP2) as a novel HNF4α corepressor, with which its interaction could not be detected by conventional immunoprecipitation. IRF2BP2 repressed transcriptional activity of HNF4α dependent on its E3 ubiquitin ligase activity. Deficiency of IRF2BP2 gene in HepG2 cells induced gluconeogenic genes comparable to the forskolin-treated wild type HepG2 cells. Together, these results suggest the role of IRF2BP2 as a novel class of nuclear receptor coregulator.
Presentation: No date and time listed
LBODP053 Significance Of Insulin Resistance And Development Of Type 2 Diabetes Mellitus
Authors: Rusalenka Mariya , Wisham Mohamed , Savasteeva Irina 
Published: November 2022

Abstract
A study was conducted via Clinical and laboratory parameters affecting the formation of insulin resistance(IR) and development of Type 2 Diabetes Mellitus. Data was collected in 140 patients below the age of 50, noted as overweight or obese. The results of the analysis demonstrated a significant direct correlation of the size of pre-peritoneal fat with fasting glycemia (rS=0.35, p&lt;0. 05) and insulin level (rS=0.33, p&lt;0. 05). The calculated risk of developing insulin resistance increased with increasing thickness of pre-peritoneal fat (b=1.46) (exp(b)=4.29 (1.54÷1.90), p=0. 005). Thus, with a size of pre-peritoneal fat of more than 1.5 cm, the relative risk (RR) of IR formation was 5.60 (2.48÷37.11). It should be noted that the linear size of subcutaneous fat did not significantly affect the development of IR. It was also noted that the risk of developing IR (exp (b) = 0.43 (0.91÷2.55), p = 0. 08)) had a steady upward trend with an increase in triglyceride levels, and amounted to 2.86 (1, 03÷7.91). At triglyceride levels above 1.75 mmol/l, the risk of developing IR was significant. When assessing the risk of developing type 2 diabetes mellitus, a steady upward trend was obtained with an increase in the thickness of pre-peritoneal fat (b=0.35; exp(b)=1.15 (0.82÷3.89; p&lt;0.10) and the level of triglycerides (b=0.56; exp(b)=1.75(0.85 ÷3.83); p&lt;0.10). In addition, the risk of developing type 2 diabetes significantly increased with age (b=0.11; exp(b)=1.12 (1. 01÷1.23), p&lt;0. 03) and amounted to 1.52 (1 . 09÷15.39) for individuals over 37.74 years. Thus, individuals over 37.74 years with linear size of pre-peritoneal fat more than 1.5 cm and level of triglycerides above 1.75 mmol/l, has a significant risk for the developing insulin resistance, type 2 diabetes mellitus and can be recommended for targeted screening.
Presentation: No date and time listed
LBODP057 Association Between DKA And Live Abscess: Results From The National Inpatient Sample
Authors: Muammar Ahmad , Mahfouz Ratib 
Published: November 2022

Abstract

Background
Diabetic ketoacidosis (DKA) is a life-threatening complication of diabetes, it can be the initial sign of unrecognized type 1 or type 2 diabetes; however, it occurs more frequently in patients with established disease, liver abscess is a life-threatening disease with an increasing rate of incidence in patient with uncontrolled diabetes, in this study we examined the association between DKA and liver abscess as formal evidence is limited, Methods This is a retrospective study using the National Inpatient Sample database from 2016 to 2019. A 20% probability sample was collected and subsequently weighted to ensure that the selected population was nationally representative. Using ICD-10-CM codes, all patients diagnosed with liver abscess were identified and considered the study population while excluding patients &lt; 18 years old. Furthermore, baseline demographic data, comorbidities, in-hospital mortality, hospital charges, and hospital length of stay were extracted and compared based on the presence or absence of a concurrent diagnosis of DKA. Statistical analyses were done using t-test and Chi-squared analysis. Finally, multivariate analysis for the mortality odds ratio was calculated after adjusting for possible confounders.

Results
From a total sample of 140 million patients, 94,600 met the criteria for this analysis and were diagnosed with liver abscess. A 0.96% of this population had a concurrent diagnosis of DKA during the same admission. Patients with liver abscess with DKA were younger than patients without DKA (58 vs. 62.17, p-value 0. 0013). The male gender was predominant in both groups without significant difference between these two groups (58.81% vs. 58.33%, respectively, p-value 0.8962). The white race was dominant in both groups, but more prevalent in non DKA group (62% vs. 44%, respectively, p-value &lt;0. 0001) The mortality rate was significantly higher in the liver abscess with DKA group (7.78% vs. 4.42%, p-value 0. 0289). Patients with DKA incurred higher costs of hospitalization ($213,792 vs. $128,730; P &lt;0. 0001) and longer length of stay (14.5 days vs. 11 days; P 0. 001) than the non-DKA group. The multivariate analysis concluded that DKA carries an odds ratio (OR) of 1.74 (CI 95% 1-3. 03, p-value 0. 049) in patients with liver abscess. In addition to DKA, age greater than 65 years, non-white race and CHF were independently associated with higher mortality. HTN, smoking and obesity were associated with decreased risk of mortality (p-value &lt;0. 001), Discussion: Our retrospective study identified association between DKA and liver abscess. DKA with liver abscess were associated with longer length of stay and higher mortality rate, treatment of the triggering factor is an essential component of the management of DKA, and liver abscess must be considered if sepsis source in DKA patient was unclear.
Presentation: No date and time listed
LBODP058 Evaluation Of Factors Associated With The Development Of Diabetic Retinopathy Based On A Case-control Study
Authors: Nathani Pratiksha Shankarlal , Kharat Pratik R , Wadde Satish , Kamdar Sheetal 
Published: November 2022

Abstract

Objectives
Diabetic Retinopathy (DR) is a microvascular complication of diabetes mellitus (DM) and one of the leading causes of irreversible vision loss, particularly in the most productive age group. Several epidemiological studies have found that diabetics worldwide and in India have a high prevalence of DR. Risk estimation of various factors has been performed earlier however there is dearth of case control studies among the diabetics who developed DR and those who were unaffected. This study was planned to identify the sociodemographic, disease related and lifestyle related risk factors for development of DR among diabetics which could broadly be categorized under modifiable and non-modifiable factors. Findings from the study could help clinicians develop predictors and risk-based screening programs for early detection of DR.

Material & Methods
In this age and gender matched case control study, total 256 diabetes mellitus patients (96% type 2) were recruited equally in groups with diabetic retinopathy (DR) and without it. Diagnosis of DR was done by fundal examination as per the Early Treatment for Diabetic Retinopathy Study (ETDRS) standard. Adherence to diabetes medications was measured using four items in vernacular language adapted from the MMAS-4 (Morisky Medication Adherence Scale). Univariate and multivariate binary logistics regression was performed to find the independent risk (Odd's ratio) and modified Odd's ratio respectively.

Results
There was parity between cases and controls in terms of gender distribution and age. Mean age of DR and non-DR group was 63.7 ± 9.5 and 63.3 ± 10.4 years respectively. Independent risk factors for development of DR were presently on insulin therapy (OR=2.87,p=0. 0001), smoking (OR=1.92,p=0. 02), alcoholism(OR=2.62,p=0. 03), sedentary lifestyle(OR=2.72,p=0. 0008), non-adherence to diabetes medications (OR=14. 08,p=0. 0001), non-adherence to dietary advice (OR=4.41,p=0. 0001), presence of other microvascular complications (OR=3.79,p=0. 0001), dyslipidemia (OR=1.85,p=0. 02) and hypertension (OR=5.91,p=0. 0001). On multivariate logistics regression analysis, non-adherence to medicine (Exp(B)=7.89,p=0. 0001) and hypertension (Exp(B)=1.16,p=0. 0001) were predictors of development of DR . Type of occupation, education, socioeconomic status and type of diabetes did not have any correlation with development of DR among diabetics.

Conclusion
Diabetics under insulin therapy and with hypertension have a seriously increased risk of developing DR. Smoking, alcohol abuse, sedentary lifestyle, failure to take diabetes medications, and failure to follow dietary advice are independent risk factors for developing DR that can be modified through lifestyle changes in diabetics. DR should be monitored more closely in patients with other microvascular complications and dyslipidemia.
Presentation: No date and time listed
LBSUN151 The Impact Of The COVID-19 Pandemic On Diabetes & Weight Management
Authors: Hashmi Hiba Z , Malham Sarah Bou , Alameddine Hind 
Published: November 2022

Abstract

COVID-19 was declared a pandemic on 03/11/2020 by the WHO and the State of Minnesota issued a stay-at-home mandate on 03/27/2020. While individuals with diabetes mellitus (DM) and severe obesity were identified as more likely to be infected and at higher risk of complications from COVID-19, access to outpatient clinics was limited during this time, with a shift towards telemedicine. In June 2020, the WHO reported that in 49% of 155 surveyed countries, diabetes treatment was disrupted. However, the impact on diabetes care in the US was poorly characterized, particularly among underserved groups.

Aim
To study the impact of the pandemic and telemedicine on medical treatment of patients with DM at Hennepin County Medical Center (HCMC), a teaching hospital in Minneapolis, Minnesota serving a diverse inner-city population.

Methods
Retrospective cohort study design with 710 participants. We compared A1C and weight changes before and after the pandemic. The study group (n=344) included patients, 18 years of age or older, with DM Type 1 or Type 2 who presented for an HCMC diabetes clinic visit between 12/2019-02/2020 and a follow up visit between 6/2020 -10/2020. The control group (n=366) included patients with DM who presented for an HCMC diabetes clinic visit between 12/2018 - 02/2019 and a follow up visit between 6/2019 - 10/2019.

Results
There was a significantly lower A1C reduction in the cases as compared to the control group (-0.34 [CI -0.59, -0. 09] p value 0. 007), adjusted for inpatient admission, continuous glucose monitor use, diabetes type 1, insurance status, insulin use, GLP-1 agonist use, smoking status and hypertension. Weight reduction during the pandemic was lower as compared to the control but did not achieve statistical significance (-0.96 [CI -3. 02, 1. 09] p value 0.36). Telemedicine use among the study group resulted in an insignificant A1c reduction of -0.24 (p value 0.23). There was statistically significant weight gain of 0.42 among the group who used telemedicine, while nonusers had weight loss of -3.24 (p value 0. 04). Telemedicine users had higher insulin utilization (92.6% vs 83.3%, p value 0. 017) and lower self-pay and Medicaid enrollment (1.7% vs 5.9% and 33.8% vs 40.6% respectively, p value 0. 011) as compared to nonusers.

Conclusion
The COVID-19 pandemic led to a significant deterioration of glycemic control but had no effect on weight. Telemedicine use led to A1c reduction but did not reach statistical significance potentially due to the small sample size and short duration of follow up. Significant weight gain was observed in telemedicine users influenced by greater insulin use and insurance coverage as compared to weight loss amongst nonusers which may be attributed to socioeconomic barriers such as food scarcity among those without the means to access telemedicine.
Presentation: Sunday, June 12, 2022 12:30 p.m. - 2:30 p.m.
LBSUN161 Relationship Of Shape Of Glucose OGTT Curves With Measures Of Cardiometabolic Health In African American Adolescents
Authors: Thaker Vidhu , Gidding Samuel , Keith Scott , Falkner Bonita 
Published: November 2022

Abstract

Background and Aims
Studies in youth and adults have shown that the shape of oral glucose tolerance test (OGTT) response curve may be a biomarker for insulin secretion and insulin sensitivity (IS). Individuals with monophasic (MPh) glucose response curve have lower IS and decreased beta-cell function compared to those with biphasic (BPh) pattern. The aim of this study was to assess if the shape of the glucose response curve of OGTT is associated with 2-D ECHO based indices of heart structure and function.

Methods
In a cross-sectional study, African American (AA) adolescents with and without obesity between the ages of 13-18 years were recruited to assess the relationship of blood pressure, obesity, and measures of cardiac health. Metabolic and inflammatory markers, 2-D ECHO and OGTT data were collected. The shape of the OGTT glucose response was classified based on a change from nadir to glucose-120 min of ≥ 4.5 mg/dL, and its association with cardiac health indices was calculated. R v.4.1.2 was used for analysis.

Results
Of the 276 individuals with available OGTT data (mean age 16.18 ± 1.70 years, 47.5% females), 39 (14.1%) had BPh curve. The individuals with BPh were lower in age (15.61 ± 1.68 vs 16.28 ± 1.68, p=0. 02), but similar in sex, BMI, BMIz and metabolic parameters. There was no difference in impaired glucose tolerance (27% [BPh] vs 15% [MPh], p=. 08). At 120 min, glucose (6.96 ± 0. 07 vs 6.31 ± 0. 07 mmol/L, p=. 05), and insulin (362.86 ± 13.69 vs 276.48 ± 13.61 uIU/mL, p=. 04) levels were higher in BPh. The glucose area under the curve (AUC) was lower in individuals with BPh (13.2 ± 1.23 vs 14.7 ± 1.16 mmol/L/hr, p &lt;. 001) while the insulinogenic index (1.5 ± 3.79 vs 1.17 ± 2.74, p =. 03) and oral glucose disposition index were higher in both univariate analyses and after adjusting for age, sex and BMIz. The aortic root size was associated with the shape of the curve adjusting for age, sex and BMIz (p=. 03), but not ventricular or atrial mass, systolic or diastolic function.

Conclusions
There was lower proportion of individuals with BPh in this cohort of AA adolescents compared to published studies. Individuals with BPh had healthier beta-cell function indices. No significant relationship of the shape of the OGTT curve was seen with the metrics of heart structure or function at this age. Replication of results in adult cohort(s) is ongoing.
Presentation: Sunday, June 12, 2022 12:30 p.m. - 2:30 p.m.