bluuebunny/crossref_metadata_2025_split huggingface dataset:
Correlation of Serum Magnesium Level and Blood Glucose status among Type 2 Diabetic Patients
Authors: Hasan KAM Mahbub , Hoque Asraful , Fatema Naheed , Anwar Mohammed Rashed , Bhuiyan AKM Mohiuddin , Haque SM Mainul , Rahman AHM Shofiur 
Published: January 2022

Background: Serum magnesium level is an important electrolytes for the maintenance of haemodynamic of the body.
Objective: The purpose of the present study was to correlate the serum magnesium level and blood sugar status.
Methodology: This cross sectional study was carried out in the Department of Medicine at Shaheed Suhrawardy Medical College Hospital, Dhaka, Bangladesh from July 2012 to December 2012. All the type 2 diabetic patients admitted in the Department of Medicine in-patient department of ShSMCH who were 18 years and above age with both sexes were included as study population and were designated as group A and non-diabetic patients were included as group B. Blood samples were drawn after an overnight fast for the measurement of fasting blood sugar and serum magnesium.
Result: In this present study a total number of 60 patients were enrolled for this study after fulfilling the inclusion and exclusion criteria of which 30 patients were in group A and the rest 30 patients were in group B. The correlation coefficient of FBS and HbA1C with Serum Magnesium level was recorded. The FBS and serum magnesium was negatively correlated to each other significantly which was -0.534. The HbA1C and serum magnesium was negatively correlated to each other significantly which was -0.556.
Conclusion: In conclusion the blood sugar level is inversely correlate with the serum magnesium level in type 2 diabetic patients.
Journal of Current and Advance Medical Research, July 2021;8(2):106-109
Analisis jasa lingkungan pangan dan air Pada Kawasan Perkotaan dan Kawasan Industri di Kabupaten Konawe
Authors: Nur Ismail , Syaf Hasbullah , Yusuf Dewi Nurhayati 
Published: January 2022

Kabupaten Konawe memilik kawasan perkotaan dan kawasan industri yang perlu diperhatikan tentang ktersediaan pangan dan air. Tujuan dari penelitian ini yaitu untuk mengetahui nilai indeks jasa lingkungan hidup di kawasan perkotaan dan kawasan industri di Kabupaten Konawe. Metode yang digunakan yaitu teknik overlay peta, bobot dan skoring, dan perhitungan indeks jasa lingkungan. Hasil dari penelitian ini yaitu pada kawasan perkotaan (Kecamatan Unaaha), penutupan lahan menempati posisi yang lebih dominan. Hal ini menunjukkan kawasan perkotaan memiliki peran dalam sektor pertanian. Kawasan industri di Kabupaten Konawe membetuk aglomerasi yang terdiri dari Kecamatan Morosi, Kecamatan Kapoila dan kecamatan Bondoala, dan sebagai penggerak ekonomi. nilai indeks jasa lingkungan penyediaan pangan yaitu 3,10 dan nilai indeks jasa lingkungan penyediaan air dengan nilai 2,33. Semakin tinggi jasa ekosistem maka semakin tinggi kemampuan daya dukung dan daya tampung lingkungan hidup. Keywords: air, kawasan, ketersediaan, pangan
Studi Klasifikasi Tingkat Kekumuhan di Kawasan Kumuh Boepinang di Bajo Barat dan Bajo Timur
Authors: Samuel Samuel , Sudia La Baco , Nur Ramadhan La Ode Ahmad 
Published: January 2022

ABSTRACT Slum areas are always a concern because of the quality of the environment that is not healthy. The method used is descriptive analysis and quantitative analysis. The results of this research are the existing conditions of slum areas in Boepinang Bajo Barat and Bajo Timur, namely: (1) the area of the slum area reaches 10.32 hectares with (a) the area of the West Bajo slum area is 4 Ha; (b) the area of the slum area of East Bajo is 6.32 Ha. Slum areas in Boepinang (East Bajo) and West Boepinang (West Bajo) Villages are included in priority scale one (1). Need attention in settlement management.Keywords ; West Bajo, East Bajo, Slum, SettlementsABSTRAK Permukiman kumuh selalu menjadi perhatian karena dari segi kualitas lingkungan yang tidak sehat. Tujuan dari penelitian ini yaitu untuk mengetahui kondisi eksisting Kawasan Kumuh Boepinang Kumuh Bajo Barat dan Bajo Timur dan untuk mengidentifikasi klasifikasi tingkat kekumuhan di Kawasan Kumuh Boepinang Kumuh Bajo Barat dan Bajo Timur. Metode yang digunakan yaitu analisis deskriptif dan analisis kuantitatif. Hasil penelitian ini yaitu Kondisi eksisting Kawasan kumuh di Boepinang Bajo Barat dan Bajo Timur sebagao berikut : (1) luas kawasan kumuh mencapai 10,32 Ha dengan (a) luas Kawasan kumuh Bajo Barat 4 Ha; (b) luas Kawasan kumuh Bajo Timur 6,32 Ha. Kawasan kumuh di Kelurahan Boepinang (Bajo Timur) dan Boepinang Barat (Bajo Barat) masuk skala prioritas satu (1). Perlu Perhatian dalam pengelolaan permukiman.Kata Kunci ; Bajo Barat, Bajo Timur, Kumuh, Permukiman
The Nonlinear Relationship Between Total Bilirubin and Coronary Heart Disease: A Dose-Response Meta-Analysis
Authors: Li Chaoxiu , Wu Wenying , Song Yumeng , Xu Shuang , Wu Xiaomei 
Published: January 2022

Background: Evidence suggests that the total bilirubin has a protective effect on coronary heart disease (CHD), but the dose-response relationship remains controversial, and there is no meta-analysis to assess the relationship.Methods: As of October 1, 2021, relevant literature was selected from four databases (PubMed, Web of Science, Cochrane Library, and Embase) by using a retrieval strategy. The dose-response curve between the total bilirubin and CHD was fitted by a restricted cubic spline. Stata 12.0 was used for statistical analysis.Results: A total of 170,209 (6,342 cases) participants from 7 prospective studies were analyzed in our meta-analysis. We calculated the pooled relative risks (RRs) and 95% CIs for the association between serum bilirubin level and risk of CHD using random-effects models. Compared with the first quantile, the bilirubin level in the third quantile had a protective effect on the risk of CHD (RR, 0.90; 95% CI, 0.82–0.99). The restricted cubic spline functions depicted a U-type curve relationship between bilirubin (3.42–49 μmol/L) and CHD (Plinear &lt; 0.001). When the bilirubin level was in the range of 3.42–13μmol/L, the protective effect of bilirubin on CHD was enhanced with increasing bilirubin levels. When the bilirubin level exceeded 13μmol/L, the protective effect of bilirubin weakened, and a dangerous effect gradually appeared with further increases in bilirubin levels.Conclusions: Compared with a low bilirubin level, a high bilirubin level has a protective effect on the risk of CHD, and there was a U-shaped dose-response relationship between them.
Advanced Warning of Aortic Dissection on Non-Contrast CT: The Combination of Deep Learning and Morphological Characteristics
Authors: Yi Yan , Mao Li , Wang Cheng , Guo Yubo , Luo Xiao , Jia Donggang , Lei Yi , Pan Judong , Li Jiayue , Li Shufang , Li Xiu-Li , Jin Zhengyu , Wang Yining 
Published: January 2022

Background: The identification of aortic dissection (AD) at baseline plays a crucial role in clinical practice. Non-contrast CT scans are widely available, convenient, and easy to perform. However, the detection of AD on non-contrast CT scans by radiologists currently lacks sensitivity and is suboptimal.Methods: A total of 452 patients who underwent aortic CT angiography (CTA) were enrolled retrospectively from two medical centers in China to form the internal cohort (341 patients, 139 patients with AD, 202 patients with non-AD) and the external testing cohort (111 patients, 46 patients with AD, 65 patients with non-AD). The internal cohort was divided into the training cohort (n = 238), validation cohort (n = 35), and internal testing cohort (n = 68). Morphological characteristics were extracted from the aortic segmentation. A deep-integrated model based on the Gaussian Naive Bayes algorithm was built to differentiate AD from non-AD, using the combination of the three-dimensional (3D) deep-learning model score and morphological characteristics. The areas under the receiver operating characteristic curve (AUCs), accuracy, sensitivity, and specificity were used to evaluate the model performance. The proposed model was also compared with the subjective assessment of radiologists.Results: After the combination of all the morphological characteristics, our proposed deep-integrated model significantly outperformed the 3D deep-learning model (AUC: 0.948 vs. 0.803 in the internal testing cohort and 0.969 vs. 0.814 in the external testing cohort, both p &lt; 0.05). The accuracy, sensitivity, and specificity of our model reached 0.897, 0.862, and 0.923 in the internal testing cohort and 0.730, 0.978, and 0.554 in the external testing cohort, respectively. The accuracy for AD detection showed no significant difference between our model and the radiologists (p &gt; 0.05).Conclusion: The proposed model presented good performance for AD detection on non-contrast CT scans; thus, early diagnosis and prompt treatment would be available.
A Comparison of the Electrophysiological and Anatomic Characteristics of Pacing Different Branches of the Left Bundle Conduction System
Authors: Liu Xi , Gu Min , Niu Hong-Xia , Chen Xuhua , Cai Chi , Zhao Junhan , Cai Minsi , Zhou Xiaohong , Gold Michael R. , Zhang Shu , Hua Wei 
Published: January 2022

Introduction: Left bundle branch pacing (LBBP) is a rapidly growing conduction system pacing technique. However, little is known regarding the electrophysiological characteristics of different types of LBBP. We aimed to evaluate the electrophysiological characteristics and anatomic lead location with pacing different branches of the left bundle branch.Methods: Consecutive bradycardia patients with successful LBBP were enrolled and classified into groups according to the paced electrocardiogram and the lead location. Electrocardiogram, pacing properties, vectorcardiogram, and lead tip location were analyzed.Results: Ninety-one patients were enrolled, including 48 with the left bundle trunk pacing (LBTP) and 43 with the left bundle fascicular pacing (LBFP). The paced QRS duration in the LBTP group was significantly shorter than that in the LBFP group (108.1 ± 9.9 vs. 112.9 ± 11.2 ms, p = 0.03), with a more rightward QRS transition zone (p = 0.01). The paced QRS area in the LBTP group was similar to that during intrinsic rhythm (35.1 ± 15.8 vs. 34.7 ± 16.6 μVs, p = 0.98), whereas in the LBFP group, the paced QRS area was significantly larger compared to intrinsic rhythm (43.4 ± 15.8 vs. 35.7 ± 18.0 μVs, p = 0.01). The lead tip site for LBTP was located in a small fan-shaped area with the tricuspid valve annulus summit as the origin, whereas fascicular pacing sites were more likely in a larger and more distal area.Conclusions: Pacing the proximal left bundle main trunk produced better electrical synchrony compared with pacing the distal left bundle fascicles. A visualization technique can facilitate achieving LBTP.
Potential Novel Serum Metabolic Markers Associated With Progression of Prediabetes to Overt Diabetes in a Chinese Population
Authors: Ren Meng , Lin Diao zhu , Liu Zhi Peng , Sun Kan , Wang Chuan , Lao Guo juan , Fan Yan qun , Wang Xiao yi , Liu Jing , Du Jie , Zhu Guo bin , Wang Jia huan , Yan Li 
Published: January 2022

BackgroundIdentifying the metabolite profile of individuals with prediabetes who turned to type 2 diabetes (T2D) may give novel insights into early T2D interception. The purpose of this study was to identify metabolic markers that predict the development of T2D from prediabetes in a Chinese population.MethodsWe used an untargeted metabolomics approach to investigate the associations between serum metabolites and risk of prediabetes who turned to overt T2D (n=153, mean follow up 5 years) in a Chinese population (REACTION study). Results were compared with matched controls who had prediabetes at baseline [age: 56 ± 7 years old, body mass index (BMI): 24.2 ± 2.8 kg/m2] and at a 5-year follow-up [age: 61 ± 7 years old, BMI: 24.5 ± 3.1 kg/m2]. Confounding factors were adjusted and the associations between metabolites and diabetes risk were evaluated with multivariate logistic regression analysis. A 10-fold cross-validation random forest classification (RFC) model was used to select the optimal metabolites panels for predicting the development of diabetes, and to internally validate the discriminatory capability of the selected metabolites beyond conventional clinical risk factors.FindingsMetabolic alterations, including those associated with amino acid and lipid metabolism, were associated with an increased risk of prediabetes progressing to diabetes. The most important metabolites were inosine [odds ratio (OR) = 19.00; 95% confidence interval (CI): 4.23-85.37] and carvacrol (OR = 17.63; 95% CI: 4.98-62.34). Thirteen metabolites were found to improve T2D risk prediction beyond eight conventional T2D risk factors [area under the curve (AUC) was 0.98 for risk factors + metabolites vs 0.72 for risk factors, P &lt; 0.05].InterpretationsUse of the metabolites identified in this study may help determine patients with prediabetes who are at highest risk of progressing to diabetes.
Different Associations Between CDKAL1 Variants and Type 2 Diabetes Mellitus Susceptibility: A Meta-analysis
Authors: Zeng Qiaoli , Zou Dehua , Gu Shanshan , Han Fengqiong , Cao Shilin , Wei Yue , Guo Runmin 
Published: January 2022

Background:CDK5 regulatory subunit associated protein 1 like 1 (CDKAL1) is a major pathogenesis-related protein for type 2 diabetes mellitus (T2DM). Recently, some studies have investigated the association of CDKAL1 susceptibility variants, including rs4712523, rs4712524, and rs9460546 with T2DM. However, the results were inconsistent. This study aimed to evaluate the association of CDKAL1 variants and T2DM patients.Methods: A comprehensive meta-analysis was performed to assess the association between CDKAL1 SNPs and T2DM among dominant, recessive, additive, and allele models.Results: We investigated these three CDKAL1 variants to identify T2DM risk. Our findings were as follows: rs4712523 was associated with an increased risk of T2DM for the allele model (G vs A: OR = 1.172; 95% CI: 1.103–1.244; p &lt; 0.001) and dominant model (GG + AG vs AA: OR = 1.464; 95% CI: 1.073–1.996; p = 0.016); rs4712524 was significantly associated with an increased risk of T2DM for the allele model (G vs A: OR = 1.146; 95% CI: 1.056–1.245; p = 0.001), additive model (GG vs AA: OR = 1.455; 95% CI: 1.265–1.673; p &lt; 0.001) recessive model (GG vs AA + AG: OR = 1.343; 95% CI: 1.187–1.518; p &lt; 0.001) and dominant model (GG + AG vs AA: OR = 1.221; 95% CI: 1.155–1.292; p &lt; 0.001); and rs9460546 was associated with an increased risk of T2DM for the allele model (G vs T: OR = 1.215; 95% CI: 1.167–1.264; p = 0.023). The same results were found in the East Asian subgroup for the allele model.Conclusions: Our findings suggest that CDKAL1 polymorphisms (rs4712523, rs4712524, and rs9460546) are significantly associated with T2DM.
Identification of Hub Biomarkers and Immune-Related Pathways Participating in the Progression of Antineutrophil Cytoplasmic Antibody-Associated Glomerulonephritis
Authors: Xia Meng-Di , Yu Rui-Ran , Chen Dong-Ming 
Published: January 2022

BackgroundAntineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a systemic autoimmune disease that generally induces the progression of rapidly progressive glomerulonephritis (GN). The purpose of this study was to identify key biomarkers and immune-related pathways involved in the progression of ANCA-associated GN (ANCA-GN) and their relationship with immune cell infiltration.MethodsGene microarray data were downloaded from the Gene Expression Omnibus (GEO). Hub markers for ANCA-GN were mined based on differential expression analysis, weighted gene co-expression network analysis (WGCNA) and lasso regression, followed by Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG) and Gene Set Enrichment Analysis (GSEA) of the differential genes. The infiltration levels of 28 immune cells in the expression profile and their relationship to hub gene markers were analysed using single-sample GSEA (ssGSEA). In addition, the accuracy of the hub markers in diagnosing ANCA-GN was subsequently evaluated using the receiver operating characteristic curve (ROC).ResultsA total of 651 differential genes were screened. Twelve co-expression modules were obtained via WGCNA; of which, one hub module (black module) had the highest correlation with ANCA-GN. A total of 66 intersecting genes were acquired by combining differential genes. Five hub genes were subsequently obtained by lasso analysis as potential biomarkers for ANCA-GN. The immune infiltration results revealed the most significant relationship among monocytes, CD4+ T cells and CD8+ T cells. ROC curve analysis demonstrated a prime diagnostic value of the five hub genes. According to the functional enrichment analysis of the differential genes, hub genes were mainly enhanced in immune- and inflammation-related pathways.ConclusionB cells and monocytes were closely associated with the pathogenesis of ANCA-GN. Hub genes (CYP3A5, SLC12A3, BGN, TAPBP and TMEM184B) may be involved in the progression of ANCA-GN through immune-related signal pathways.
Lower Rate of Daily Smokers With Symptomatic COVID-19: A Monocentric Self-Report of Smoking Habit Study
Authors: Miyara Makoto , Tubach Florence , Pourcher Valérie , Morélot-Panzini Capucine , Pernet Julie , Haroche Julien , Lebbah Said , Morawiec Elise , Gorochov Guy , Caumes Eric , Hausfater Pierre , Combes Alain , Similowski Thomas , Amoura Zahir 
Published: January 2022

Background: Identification of prognostic factors in COVID-19 remains a global challenge. The role of smoking is still controversial.Methods: PCR-positive in- and outpatients with symptomatic COVID-19 from a large French University hospital were systematically interviewed for their smoking status, use of e-cigarette, and nicotinic substitutes. The rates of daily smokers in in- and outpatients were compared using the same smoking habit questionnaire to those in the 2019 French general population, after standardisation for sex and age.Results: The inpatient group was composed of 340 patients, median age of 66 years: 203 men (59.7%) and 137 women (40.3%), median age of both 66 years, with a rate of 4.1% daily smokers (CI 95% [2.3–6.9]) (5.4% of men and 2.2% of women). The outpatient group was composed of 139 patients, median age of 44 years: 62 men (44.6%, median age of 43 years) and 77 women (55.4%, median age of 44 years). The daily smoker rate was 6.1% (CI 95% [2.7–11.6], 5.1% of men and 6.8% of women). Amongst inpatients, daily smokers represented 2.2 and 3.4% of the 45 dead patients and of the 29 patients transferred to ICU, respectively. The rate of daily smokers was significantly lower in patients with symptomatic COVID-19, as compared to that in the French general population after standardisation by age and sex, with standardised incidence ratios (SIRs) of 0.24 [0.12–0.48] for outpatients and 0.24 [0.14–0.40] for inpatients.Conclusions: Daily smoker rate in patients with symptomatic COVID-19 is lower as compared to the French general population
What Is the Evidence on Natural Recovery Over the Year Following Sports-Related and Non-sports-Related Mild Traumatic Brain Injury: A Scoping Review
Authors: Brady Morgan , Hume Patria A. , Mahon Susan , Theadom Alice 
Published: January 2022

Background: Treatment approaches often differ dependent upon whether a person experiences a sports-related or a non-sports-related mild traumatic brain injury. It remains unclear if recovery from these injuries is comparable or unique to context of the injury.Objective: To identify knowledge gaps on self-reported outcomes and trajectories between sports- and non-sports-related mild traumatic brain injuries and how they are assessed in adults.Methods: This scoping review used a systematic search of key electronic databases, including PubMed, SPORTDiscus, Embase, MEDLINE, and CINAHL for articles published in 1937 until March 10, 2021. Articles were included if they were available in English; full text published in a peer-reviewed journal; had a prospective or retrospective study design; reported data on mild TBI cases &gt;16 years of age, and included data from at least two time points on self-reported outcomes within 12 months post-injury. A standardized data extraction spreadsheet was used to determine the participant characteristics, definitions, assessment methods, outcomes, and recovery time frames.Results: Following removal of duplicates, the search strategy elicited 6,974 abstracts. Following abstract review, 174 were retained for full text review. Of the 42 articles that met inclusion criteria, 18 were sports related (15 in the USA and three in Canada) and 24 were general population studies (six in USA, three in Canada, three in Australasia, nine in Europe, two in Taiwan, and one in Morocco). Direct comparison in recovery trajectories between the sport and general population studies was difficult, given notable differences in methodology, definitions, types of outcome measures, and timing of follow-up assessments. Only one article reported on both sports-related and non-sports-related traumatic brain injuries separately at comparable timepoints. This study revealed no differences in recovery time frames or overall symptom burden.Discussion: Whilst there is a clear benefit in researching specific subpopulations in detail, standardized outcome measures and follow-up time frames are needed across contexts to facilitate understanding of similarities and differences between sports- and non-sports-related mild traumatic brain injuries to inform clinical treatment.
Early Deterioration and Long-Term Prognosis of Patients With Intracerebral Hemorrhage Along With Hematoma Volume More Than 20 ml: Who Needs Surgery?
Authors: Lin Fuxin , He Qiu , Tong Youliang , Zhao Mingpei , Ye Gezhao , Gao Zhuyu , Huang Wei , Cai Lveming , Wang Fangyu , Fang Wenhua , Lin Yuanxiang , Wang Dengliang , Dai Linsun , Kang Dezhi 
Published: January 2022

Background and Purpose: The treatment of patients with intracerebral hemorrhage along with moderate hematoma and without cerebral hernia is controversial. This study aimed to explore risk factors and establish prediction models for early deterioration and poor prognosis.Methods: We screened patients from the prospective intracerebral hemorrhage (ICH) registration database (RIS-MIS-ICH, ClinicalTrials.gov Identifier: NCT03862729). The enrolled patients had no brain hernia at admission, with a hematoma volume of more than 20 ml. All patients were initially treated by conservative methods and followed up ≥ 1 year. A decline of Glasgow Coma Scale (GCS) more than 2 or conversion to surgery within 72 h after admission was defined as early deterioration. Modified Rankin Scale (mRS) ≥ 4 at 1 year after stroke was defined as poor prognosis. The independent risk factors of early deterioration and poor prognosis were determined by univariate and multivariate regression analysis. The prediction models were established based on the weight of the independent risk factors. The accuracy and value of models were tested by the receiver operating characteristic (ROC) curve.Results: After screening 632 patients with ICH, a total of 123 legal patients were included. According to statistical analysis, admission GCS (OR, 1.43; 95% CI, 1.18–1.74; P &lt; 0.001) and hematoma volume (OR, 0.9; 95% CI, 0.84–0.97; P = 0.003) were the independent risk factors for early deterioration. Hematoma location (OR, 0.027; 95% CI, 0.004–0.17; P &lt; 0.001) and hematoma volume (OR, 1.09; 95% CI, 1.03–1.15; P &lt; 0.001) were the independent risk factors for poor prognosis, and island sign had a trend toward significance (OR, 0.5; 95% CI, 0.16-1.57; P = 0.051). The admission GCS and hematoma volume score were combined for an early deterioration prediction model with a score from 2 to 5. ROC curve showed an area under the curve (AUC) was 0.778 and cut-off point was 3.5. Combining the score of hematoma volume, island sign, and hematoma location, a long-term prognosis prediction model was established with a score from 2 to 6. ROC curve showed AUC was 0.792 and cutoff point was 4.5.Conclusions: The novel early deterioration and long-term prognosis prediction models are simple, objective, and accurate for patients with ICH along with a hematoma volume of more than 20 ml.