bluuebunny/crossref_metadata_2025_split huggingface dataset:
Coping with uncertainty in mental illness: Associations among desired support, support seeking strategies, and received support from family members
Authors: Kuang Kai , Wang Ningxin 
Published: August 2022

Individuals with mental illness commonly experience uncertainty related to not only the condition itself but also personal and social implications surrounding mental illness. Support from family has the potential to alleviate uncertain feelings and reduce perceived stress. Drawing on the sensitive interaction systems theory, this longitudinal study investigated the support seeking processes and outcomes in mental illness. Results suggested that perceived uncertainty about mental illness was negatively associated with desired emotional and informational support from close family. Desired support predicted received support and reduced perceived stress 2 weeks later. The effect of desired support on received support was mediated by direct support seeking behaviors. Communication efficacy, relational trust, and motivation to seek support moderated the associations between desired support and support seeking behaviors. Findings offer theoretical and practical implications for support seeking from family members in mental illness.
Impact of perfusion method on perioperative red blood cell transfusions and new-onset postoperative atrial fibrillation in mitral valve surgery patients
Authors: Räsänen Jenni , Ellam Sten , Hartikainen Juha , Juutilainen Auni , Halonen Jari 
Published: August 2022

Introduction Red blood cell (RBC) transfusions are common in cardiac surgery and reportedly associated with increased mortality and morbidity, including increased risk of postoperative new-onset atrial fibrillation (NOAF). The aim of this study was to compare minimal invasive extracorporeal circulation (MiECC) and conventional extracorporeal circulation (CECC) in terms of RBC transfusions and the incidence of NOAF in mitral valve surgery. Methods The study population consisted of 89 MiECC and 169 CECC patients undergoing mitral valve surgery as an isolated procedure (80.6% of the patients) or in combination with coronary artery bypass grafting (19.4% of patients). 79.4% of the patients were male and the mean age was 62.1 years. Results 30.0% of patients aged < 65 years and 48.1% of patients aged ≥ 65 years needed RBC transfusion. The overall need for RBC transfusions did not differ between the treatment groups. Among patients < 65 years of age transfusions of ≥ 3 units were less frequent in MiECC than in CECC patients (OR 0.31, 95% CI 0.10–0.98, p = 0.045). The overall incidence of NOAF was 41.8% with no significant difference between MiECC and CECC groups. Red blood cell transfusions were associated with an increased risk of NOAF in an unadjusted analysis but not after adjustment for age and sex (OR 1.25, 95% CI 0.64–2.43, p = 0.515). Conclusions In mitral valve surgery MiECC compared to CECC was associated with less need of RBC units and platelets, particularly in patients aged < 65 years. Use of RBC transfusions was associated with increased risk of NOAF significantly only in unadjusted analysis.
Effectiveness of Bone Marrow–Derived Platelet-Rich Fibrin on Rotator Cuff Healing in a Rabbit Degenerative Model
Authors: Uno Tomohiro , Maruyama Masahiro , Satake Hiroshi , Takakubo Yuya , Toyono Shuji , Xing Liu , Huang Hanqing , Yuki Issei , Suzuki Akemi , Mura Nariyuki , Takagi Michiaki 
Published: August 2022

Background: Platelet-rich fibrin (PRF) is a second-generation platelet concentrate. Although peripheral blood–derived PRF (P-PRF) is commonly applied in biological augmentation, there is no report about the therapeutic effect of bone marrow–derived PRF (BM-PRF) for degenerative rotator cuff tears (RCTs). Purpose/Hypothesis: To examine the effects of platelet-rich plasma (PRP), P-PRF, and BM-PRF during rotator cuff repair (RCR) in degenerative RCTs in rabbits. We hypothesized that BM-PRF would accelerate the bone-tendon healing after RCR. Study Design: Controlled laboratory study. Methods: Degenerative RCT models were created 2 weeks before beginning the study, and 68 juvenile rabbits were divided into 4 groups: the control, PRP, P-PRF, and BM-PRF groups. RCR without augmentation was done in the control group. PRP was prepared by centrifuging peripheral blood twice using a plastic tube. P-PRF and BM-PRF were prepared by centrifuging peripheral blood and bone marrow, respectively, using a glass tube. Rabbits from PRP, P-PRF, and BM-PRF groups were administered the augmentation in a similar fashion for RCR, between the rotator cuff and the footprint of the humerus. At 4, 8, and 12 weeks, rabbits were euthanized and histologically assessed using hematoxylin and eosin staining, Alcian blue staining, and immunohistochemical staining for type I and III collagen. The sections were also evaluated with immunofluorescence staining of vascular endothelial growth factor (VEGF) at 4 weeks. Results: The continuity was significantly better in the BM-PRF group at 4 weeks ( P < .05). Immunofluorescence staining demonstrated that VEGF-positive stained cells were significantly greater in the BM-PRF group than in the control group ( P < .01). The modified tendon maturing score was significantly greater in the BM-PRF group than in the control and PRP groups at 12 weeks ( P < .05). There was no significant difference in the modified tendon maturing score of the P-PRF group compared with the control group. Conclusion: The rabbit model of degenerative RCTs demonstrated that RCR combined with BM-PRF enhanced tendon-bone continuity and increased the VEGF-positive cells at 4 weeks and obtained preferable tendon-bone maturation at 12 weeks. Clinical Relevance: RCR augmented with BM-PRF has the potential to improve clinical outcomes for RCTs.
Caring Contacts to Reduce Psychiatric Morbidity Following Hospitalization During the COVID-19 Pandemic: A Pilot Randomized Controlled Trial
Authors: Holman Sarah , Steinberg Rosalie , Sinyor Mark , Lane Hillary , Starritt Kaleigh , Kennedy Sidney H. , Niederkrotenthaler Thomas , Zaretsky Ari , Castel Saulo , Schaffer Ayal 
Published: August 2022

Objectives Caring Contacts are an emerging intervention that aims to reduce distress and suicide risk after acute psychiatric care. This trial aimed to determine whether, during a pandemic, there was any evidence that the mental health benefits and reduction in suicidal ideation (SI) associated with delivering Caring Contacts to recently discharged psychiatric patients were greater than a control communication. The secondary objective was to identify whether the predicted benefits were greater among people living alone or those diagnosed with depression. Method A single-site pilot randomized clinical trial ( n = 100), with patients recruited from the adult Inpatient Psychiatry Unit at Sunnybrook Health Sciences Centre, Toronto, Canada between August 2020 and May 2021. Participants were randomized (1:1) to the Caring Contact or control group. Participants received three Caring Contact or control communications via email or mail (on days 4, 21, and 56 post-discharge). Mental health symptoms were assessed using the self-report Hopkins Symptom Checklist-25 (HSCL-25) scores at discharge (baseline) and when participants received each communication. Analysis of variance was used for the primary comparisons and exploratory analyses for subgroups. Results Both groups experienced a significant worsening of mental health symptoms at all time points post-discharge relative to baseline. There were no significant differences between groups at any time point, however, on day 4 there was a 24.2% and 72.6% attenuated worsening in the Caring Contact group compared to the control group for total symptom severity and SI, respectively. There was no significant interaction effect for the depression subgroup or those living alone. Conclusions While this pilot study was not powered to identify significant differences between groups, results are indicative of feasibility and acceptability of the intervention and provide some indication that Caring Contacts may have benefited patients in the days following discharge, supporting the need for larger-scale trials. The study was registered with clinicaltrials.gov (study ID NCT04456062).
Late-onset cutaneous lupus erythematosus patients have distinctive clinical features and demographics versus early-onset patients
Authors: Anderson Scott R , Hynan Linda S , Chong Benjamin F 
Published: August 2022

Background Cutaneous lupus erythematosus (CLE) can present later in life, but frequency and risk factors of late-onset CLE patients are not well characterized. The study determined frequency of late-onset CLE and compared the demographic and disease characteristics between early-onset and late-onset CLE in a cohort of patients with CLE. Objectives To determine the frequency and compare clinical features of early-onset and late-onset CLE. Methods This was a cross-sectional study of CLE patients seen in outpatient dermatology clinics at University of Texas Southwestern Medical Center (UTSW) and Parkland Health and Hospital System, Dallas, TX, from April 2009 to May 2019. The primary outcome was the age of CLE onset, stratified by early-onset (<50 years) and late-onset CLE (≥50 years). Predictor variables significantly associated with CLE onset groups were identified by univariate and multivariable logistic regression analyses. Results Of the 291 CLE patients studied, 79% were early-onset, and 21% were late-onset. Multivariable logistic regression analyses identified that Caucasian race (odds ratio (OR): 2.23, 95% Confidence Interval (CI): 1.19–4.19, p = 0.013), having a CLE subtype other than chronic (OR: 2.18, 95% CI: 1.02–4.65, p = 0.044), and drug-induced cases (OR: 4.65, 95% CI: 1.18–18.24, p = 0.028) were significantly associated with late-onset CLE. Early-onset CLE patients were more likely to have oral ulcers (OR: 3.58, 95% CI: 1.46–8.78, p = 0.005) and renal disorders (OR: 4.02, 95% CI: 1.10–14.71, p = 0.036). Limitations This was a single center study. Age of onset was self-reported and late-onset CLE cohort has a small sample size. Conclusions Our diverse cohort of CLE patients had about one out of five patients with CLE experiencing disease onset after 50 years old. These patients have distinct demographic and clinical presentations compared to early-onset CLE patients. Providers should remain mindful of CLE in older patients with photosensitive rashes and mild systemic symptoms.
Systemic inflammation index as useful tool to predict arteriovenous graft stenosis: Our experience and literature review
Authors: Franchin Marco , Muscato Paola , Piffaretti Gabriele , Tozzi Matteo 
Published: August 2022

Objective: Many studies show that settings of severe inflammatory stress might be responsible for changes in circulating blood cells count. Effective inflammation indices are created calculating the quantitative relationship between these cells. No previous studies have been proposed on hemodialysis patients exploring the association between arteriovenous graft (AVG) stenosis and systemic inflammation markers, such as Neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), and systemic-immune-inflammation index (SII). Methods: Patients undergone surgery for AVG creation in a 2-year period are examined. Examining their full blood count, we have established the value of inflammatory indices (NLR, PLR, SII) and we have compared their mean values in patients who have developed significant stenosis or not. Finally, we have considered the connection between those values and stenosis onset and recurrence in AVG. Results: Fifty-two patients are included in the study [male: 40%, mean age 70 ± 15 years (range 55–86)]. We have found out there is not statistical significance in preoperative values of inflammatory index (NLR p 0.33, PLR p 0.15, SII p 0.98) Otherwise NLR and SII indices were statistically significant 3 months after surgery (NLR 2.04 ± 0.98 vs 3.91 ± 2.10, p < 0.001; SII 415.32 ± 255.15 vs 636.91 ± 349.01, p 0.014). Conclusions: Increased post-operative values of NLR and SII have proved a strong association with AVG outflow stenosis onset and recurrence.
Three New Phenolic Compounds from Sabia parviflora and Their Hepatoprotective Activity
Authors: He Huan , Du Wei Dong , Zhou Qiang , Wang Qi , Li Zhi Feng , Fang Yuanying , Feng Yulin 
Published: August 2022

Three compounds were obtained from Sabia parviflora Wall., and their structures were identified through nuclear magnetic resonance (NMR) spectroscopy, particularly 2-dimensional (2D)-NMR. The molecular masses were determined using quadrupole-time-of-flight-mass spectrometry. Electronic circular dichroism spectra were used to determine the absolute configuration of compound 1. The 3 new compounds were identified as 2,2,7,7-tetramethyl-8S,10-dihydroxy-2,7,8,9-tetrahydro-2H-naphtha[2,3-b]pyran-6-one-10- O- β-D-glucopyranoside, (2Z)-4-(3-carboxy-4-hydroxyphenyl)-2-methylbut-2-enoic acid, and (2Z)-5-(3-carboxy-4-hydroxyphenyl)-5-oxo-2-methylpent-2-enoic acid. The liver protective activities of these compounds were tested by HepG2 and LO2 cell lines, which were induced using free fatty acids.
Therapeutic decisions in a cohort of patients with idiopathic pulmonary fibrosis: a multicenter, prospective survey from Poland
Authors: Górska Katarzyna , Maskey-Warzęchowska Marta , Barnaś Małgorzata , Białas Adam , Barczyk Adam , Jagielska-Len Hanna , Jassem Ewa , Kania Aleksander , Lewandowska Katarzyna , Majewski Sebastian , Martusewicz-Boros Magdalena M. , Piotrowski Wojciech J. , Siemińska Alicja , Sładek Krzysztof , Sobiecka Małgorzata , Trzaska-Sobczak Marzena , Tomkowski Witold , Żołnowska Beata , Krenke Rafał 
Published: August 2022

Background: Pirfenidone and nintedanib are considered as the standard of care in idiopathic pulmonary fibrosis (IPF), but there is no consensus as to which of these two agents should be regarded as first-line treatment. Objective: To provide real-world data on therapeutic decisions of pulmonary specialists, particularly the choice of the antifibrotic drug in patients with IPF. Methods: This was a multicenter, prospective survey collecting clinical data of patients with IPF considered as candidates for antifibrotic treatment between September 2019 and December 2020. Clinical characteristics and information on the therapeutic approach were retrieved. Statistical evaluation included multiple logistic regression analysis with stepwise model selection. Results: Data on 188 patients [74.5% male, median age 73 (interquartile range, 68–78) years] considered for antifibrotic therapy were collected. Treatment was initiated in 138 patients, while 50 patients did not receive an antifibrotic, mainly due to the lack of consent for treatment and IPF severity. Seventy-two patients received pirfenidone and 66 received nintedanib. Dosing protocol ( p < 0.01) and patient preference ( p = 0.049) were more frequently associated with the choice of nintedanib, while comorbidity profile ( p = 0.0003) and concomitant medication use ( p = 0.03) were more frequently associated with the choice of pirfenidone. Age ( p = 0.002), lung transfer factor for carbon monoxide (TLCO) ( p = 0.001), and gastrointestinal bleeding ( p = 0.03) were significantly associated with the qualification for the antifibrotic treatment. Conclusion: This real-world prospective study showed that dose protocol and patient preference were more frequently associated with the choice of nintedanib, while the comorbidity profile and concomitant medication use were more frequently associated with the choice of pirfenidone. Age, TLCO, and history of gastrointestinal bleeding were significant factors influencing the decision to initiate antifibrotic therapy.
The Accuracy of Self-Perception of Obesity in a Rural Australian Population: A Cross-Sectional Study
Authors: Seth Nimish , Seal Alexa , Ruchin Peter , McGirr Joe 
Published: August 2022

Introduction: Obesity is a major public health concern. Accurate perception of body weight may be critical to the successful adoption of weight loss behavior. The aim of this study was to determine the accuracy of self-perception of BMI class. Methods: Patients admitted to the acute medical service in one regional hospital completed a questionnaire and classified their weight as: “underweight,” “normal,” “overweight,” or “obese.” Reponses were compared to clinically measured BMIs, based on the WHO Classification. Patients were also questioned about health-related behavior. Data were analyzed via Pearson’s Chi-squared test. Results: Almost 70% of the participating patient population (n = 90) incorrectly perceived their weight category, with 62% underestimating their weight. Only 34% of patients who were overweight and 14% of patients with obesity correctly identified their weight status. Two-thirds of patients who were overweight and one-fifth of patients with obesity considered themselves to be “normal” or “underweight.” Patients with obesity were 6.5-fold more likely to misperceive their weight status. Amongst patients with overweight/obesity, those who misperceived their weight were significantly less likely to have plans to lose weight. Almost 60% had not made any recent health behavior changes. This is one of the first regional Australian studies demonstrating that hospitalized patients significantly misperceive their weight. Conclusion: Patients with overweight/obesity had significantly higher rates of weight misperception and the majority had no intention to lose weight or to undertake any health behavior modification. Given the association between weight perception and weight reduction behavior, it introduces barriers to addressing weight loss and reducing the increasing prevalence of obesity in rural Australia. It highlights that doctors have an important role in addressing weight misperception.
Association Between COPD Symptoms and Psychological Distress Among Farmers
Authors: Kham-ai Prasert , Heaton Karen , Li Peng 
Published: August 2022

Background: Farmers have an increased risk of developing chronic obstructive pulmonary disease (COPD) and psychological distress. The potential role of psychological distress in worsening COPD symptoms has been reported among the general population, but no studies have examined this relationship among farmers with COPD, which is the purpose of this study. Methods: This study used the data from the 2017 Behavioral Risk Factor Surveillance System (BRFSS). Farmers reporting both psychological distress and COPD symptoms were included in this study ( n = 239). Both unadjusted and adjusted logistic regressions were used to explore the association among psychological distress, age, health status, smoking, and COPD symptoms, with crude and adjusted odds ratio (OR) and 95% CIs reported. Findings: The unadjusted analysis suggested that COPD symptoms were significantly associated with psychological distress among farmers (OR = 2.05 [1.18, 3.58]). While adjusted models showed the significant association between COPD symptoms and psychological distress among farmers after controlling for smoking, age, and health status (adjusted OR = 2.08 [1.10, 4.01]). Conclusion/Implications for Practice: These results suggest that psychological distress is associated with an increased risk of COPD symptoms in farmers, which is consistent with observations from studies in non-farmers. Occupational health professionals need to provide screen for COPD among farmers as well as psychological distress screening and mental health promotion among farmers with COPD.
Mechanical, Chemical, and Biological Properties of 3D-Printed Abutments: A Systematic Review
Authors: Campos Murilo Rodrigues de , Oliveira Thaísa Theodoro de , Botelho André Luís , Reis Andréa Cândido dos 
Published: August 2022

Aim: A systematic review of the methods of 3D printing and the materials used so far for the manufacture of abutments was performed to evaluate whether their clinical use is indicated through the mechanical, chemical, and biological analyses carried out. Materials and Methods: An electronic search conducted by three independent reviewers was carried out in the PubMed, Web of Science, Cochrane Library, Science Direct, and Lilac databases. The inclusion criterion was researching articles in English that contained as subject the manufacturing of abutments through 3D printing/additive manufacturing. Any meta-analyses, reviews, book chapters, abstracts, letters, conferences papers, and studies without abutments printed were excluded. Results: We found 780 references, which after applying the exclusion criteria resulted in the final inclusion of seven articles for review. The studies had a high heterogeneity, showing different materials and methodologies to manufacture abutments, which makes a comparison between them difficult, and for this reason it was not possible to carry out a meta-analysis with the data found. Conclusions: Even with the limitations found in the present research, it is possible to conclude that printed abutments have adequate mechanical, chemical, and biological properties that can indicate their clinical use. 3D printing presents high accuracy and speed and can produce customized abutments according to each case.
Effect of wood attributes on the price persistence of acoustic guitars
Authors: Zhou Xiaoxiao , Miyauchi Ryoga , Inoue Yuki 
Published: August 2022

AbstractWood attributes are important, because they directly affect the price persistence of wood products. Consumers consider the “aesthetic,” “traditionality,” “decay resistance,” and “scarcity” attributes important when evaluating wood. This study analyzed the impact of these four attributes on the price persistence of acoustic guitars. We obtained data from a Japanese internet auction platform and winning-bid data for two representative brands, Martin and Yamaha. We performed a quantitative analysis using the winning bid price as the dependent variable and the adoption of various wood attributes in each part of the guitar corresponding to the four attributes as explanatory variables. We found that rosewood, mahogany, palisander, and ebony have a significant impact on price persistence, and that all of them fit the four attributes of traditionality, decay resistance, scarcity, and aesthetics. We also found that traditionality was the key attribute among the four. Using wood in luxury brands without traditionality was not effective, even if other attributes were present. For mass-market brands, scarcity and decay resistance had positive effects on price persistence. The finding that scarcity and decay resistance were important only for mass-market brands can help companies understand market demand, determine product attributes, and achieve product–market fit.