bluuebunny/crossref_metadata_2025_split huggingface dataset:
Die schizoaffektive Störung
Authors: Kugelmann Melanie , Graf Heiko , Rüger Alexander , Schönfeldt-Lecuona Carlos 
Published: February 2022

ZUSAMMENFASSUNG
Hintergrund Die Diagnose einer schizoaffektiven Störung (SAS) weist im Vergleich zu anderen psychischen Erkrankungen eine nur sehr niedrige Interrater-Reliabilität auf. Eine mögliche Ursache hierfür kann in Unterschieden diagnostischer Kriterien zwischen den verschiedenen Klassifikationssystemen ICD-10 und DSM-5 liegen, die mit dieser Arbeit untersucht werden sollen. Insbesondere werden auch die Abweichungen zwischen verschiedenen Ausgaben der ICD-10 berücksichtigt.
Methode Die Kriterien zur Diagnose der SAS im Taschenführer zur ICD-10, in den klinisch-diagnostischen Leitlinien zur ICD-10 sowie im DSM-5 wurden systematisch miteinander verglichen. Ebenso berücksichtigt wurden hierbei die Ausschlusskriterien verwandter psychischer Störungen.
Ergebnisse Alle 3 genannten Klassifikationssystemen stimmen darin überein, dass die SAS durch affektive Symptome und mindestens ein schizophrenes Symptom einer Schizophrenie charakterisiert ist. Deutliche Unterschiede liegen jedoch in der genauen Symptomspezifikation, der für die Diagnose erforderlichen Dauer und zeitlichen Überlappung der Symptome, den Ausschlusskriterien und in möglichen Zusatzkodierungen (insbesondere Remissionen).
Schlussfolgerung Sowohl zwischen DSM-5 und ICD-10 als auch zwischen den zur Verfügung stehenden Versionen der ICD-10 unterscheiden sich die Diagnosekriterien einer SAS zum Teil deutlich. Dieser Artikel soll eine Übersicht zur Vereinfachung der Kommunikation bieten. Bei der Einführung der ICD-11 ist darauf zu achten, innerhalb dieses Manuals einheitlicher zu werden und einen besseren Übergang zum DSM-5 zu ermöglichen.
Tolerability of skin biopsy after epinephrin-containing local anaesthesia in postural tachycardia syndrome
Authors: Maier Andrea , Schauermann Joana C , Koch Julia , Schulz Jörg B. 
Published: February 2022

ZUSAMMENFASSUNG
Gegenstand und Ziel Viele Patienten mit posturalem Tachykardie-Syndrom (PoTS) erhalten eine Hautbiopsie, um eine mögliche Small Fiber Neuropathie (SFN) zu erkennen. Ziel der Fragebogenstudie war es, mögliche Nebenwirkungen nach Lokalanästhesie mit Adrenalinzusatz zu erkennen.
Material und Methoden 52 Patienten (29 PoTS, 23 SFN) füllten die retrospektive Befragung aus. Es wurde eine qualitative deskriptive und quantitative Datenanalyse mit Zwischensubjektdesign durchgeführt.
Ergebnisse Alle Nebenwirkungen wurden bei PoTS (32 Items, relative Häufigkeit 15,8 %) häufiger als bei SFN-Patienten (8 Items, 5,0 %), entweder während oder nach der Biopsie (p = 0,027) beschrieben. Nur Patienten mit PoTS beschrieben Hämatome und verlängerte Blutung.
Schlussfolgerung In der klinischen Routine besteht Unsicherheit bei Patienten, ob die Hautbiopsie unter Lokalanästhesie mit Adrenalinzusatz Nebenwirkungen haben kann. In dieser Pilotstudie zeigten sich keine schwerwiegenden Nebenwirkungen, die die Durchführung der Hautbiopsien in der klinischen Diagnostik bei PoTS einschränken könnten.
Klinische Relevanz Auf Basis dieser Daten wird eine prospektive Studie durchgeführt.
Differenzierte Sportbefreiung als Chance: Ergebnisse eines
Online-Survey und Übersicht über die aktuelle
Literatur
Authors: König Tatjana Tamara , Heimann Alexander , Scharenberg Swantje , Kriemler Susi , Muensterer Oliver , Siaplaouras Jannos 
Published: February 2022

Zusammenfassung
Hintergrund Die körperliche Aktivität in der Schule
trägt relevant zur Bewegungszeit von Schüler*innen bei.
Eine differenzierte ärztliche Sportbefreiung (dSB) ermöglicht
die angepasste Teilnahme am Sportunterricht im Rahmen der individuellen
körperlichen Leistungsfähigkeit.
Methode Online-Befragung von Ärzt*innen (2019) und
Lehrkräften (zwei Wellen, 2017/19). Neben demographischen
Parametern wurden Fragen zur dSB in der Praxis anhand einer 6-Punkt-Likert-Skala
erhoben. Mittelwerte wurden mit 95%-Konfidenzintervall (95%-KI)
berechnet.
Ergebnisse 97 Ärzt*innen und 280 Sportlehrkräfte
nahmen teil. Durchschnittlich nahmen 10,3% (95%-KI:
9,5–11,1%) der Schüler*innen nicht am
Sportunterricht teil. Die Schüler*innen wurden meist direkt von
den Eltern entschuldigt. Als Gründe wurden vergessene Sportkleidung
(62%), akute Infekte (54%), Verletzungen (50%)
angegeben. Chronische Erkrankungen waren selten (8%). Die meisten
Lehrkräfte (63%) fühlen sich nicht gut auf den Umgang
mit Schüler*innen mit chronischen Erkrankungen im
Sportunterricht vorbereitet. 24% der Ärzt*innen hatten
noch nie über eine DSB nachgedacht. Alle Befragten hielten eine dSB
für statistisch relevant sinnvoller als eine Befreiung von der
Notengebung.
Diskussion Ärzte und Lehrkräfte halten das Konzept der dSB
für sinnvoll und umsetzbar. Eine Befreiung von der Notengebung kommt als
sekundäre Option in Frage.
Schlussfolgerung Die differenzierte Sportbefreiung ist ein sinnvolles,
aber nicht weit verbreitetes Konzept, das in vielen unterschiedlichen Szenarien
angewendet werden kann. Um eine optimale Integration aller Kinder und
Jugendlichen im Sportunterricht zu erreichen, sollte ein
allgemeingültiges, standardisiertes System entwickelt werden.
Prevention of Premature Ovulation by Administration of Gonadotropin Releasing Hormone Antagonist the day After Ovulation Triggering in Diminished Ovarian Reserve Patients
Authors: Sik Bulat Aytek , Ozolcay Ozan , Aba Yilda Arzu , Sismanoglu Alper , Savas Sifa , Oral Serkan 
Published: February 2022

AbstractObjective The aim of the present retrospective study was to investigate the effectiveness of single-dose gonadotropin releasing hormone (GnRH) antagonist administration, the day after human chorionic gonadotropin (hCG) triggering for final oocyte maturation, on the prevention of premature luteinization in patients with diminished ovarian reserve in in-vitro fertilization (IVF) cycles. The secondary objective of the study was to search the effect of this protocol on pregnancy outcomes.Methods This is a retrospective study including 267 infertile patients who have single antral follicle seen with ultrasonography on the 2nd or 3rd day of the menstrual cycle before starting IVF treatment. We randomized patients into two groups. The case group comprised patients who had single-dose GnRH antagonist injection the day after hCG triggering formed, and the patients who had the standard treatment regime formed the control group. In both groups, the oocytes were collected 36 hours after hCG injection.Results The premature ovulation rate was significantly low in the case group compared with the control group (6.86 versus 20.6% per scheduled cycle) (p = 0.022). Also, the oocyte retrieval rate (93.14 versus 67.87% per scheduled cycle) (p = 0.013), the oocyte maturity rate (79.42 versus 47.87%) (p = 0.041), the fertilization rate (65.68 versus 34.54%) (p = 0.018), and the embryo transfer rate per scheduled cycle (44.11 versus 18.78%) (p = 0.003) were higher in the GnRH antagonist group than in the control group.Conclusion The administration of GnRH antagonist the day after hCG trigger in IVF treatments of patients with diminished ovarian reserve enabled a significant decrease in the rate of premature ovulation but had no effect on live birth rate.
DMSO-Mediated Difunctionalization of Electron-Deficient Olefins to Access β-Hydroxysulfides with High Chemoselectivity
Authors: Gao Bao , Liu Xiaojun , Zhang Xiuli , Yan Qian , Yang Ruiting , Jiang Tao 
Published: February 2022

AbstractA novel and convenient method for the highly chemoselective synthesis of β-hydroxysulfides mediated by DMSO is reported. This eco-friendly reaction was amenable to a broad range of substrates and provided the desired β-hydroxysulfides in moderate to good yields with high selectivity via radical process. Moreover, several pharmaceutical and bioactive molecules were also suitable substrates for this reaction conditions to afford the targeted products in good yields.
Impacto do ácido hialurônico na viabilidade das células mesenquimais derivadas do tecido adiposo cultivadas em membrana de colágeno tipo I/III
Authors: Kaleka Camila Cohen , Debieux Pedro , Antonioli Eliane , Zucconi Eder , Cohen Moisés , Ferretti Mário 
Published: February 2022

Resumo
Objetivo Avaliar in vitro a viabilidade das células-tronco mesenquimais derivadas do tecido adiposo (AD-CTMs) em diferentes soluções comerciais de ácido hialurônico (AH) antes e após serem semeadas em membrana de colágeno I/III.
Métodos Na primeira etapa, analisou-se a interação entre AD-CTMs com sete diferentes produtos comerciais de AH, salina tamponada com fosfato (PBS, na sigla em inglês) e soro fetal bovino (SFB), realizada pela contagem das células vivas e mortas após 24, 48 e 72 horas. Foram selecionados cinco produtos com maior número de células vivas e avaliou-se a interação entre o AH com AD-CTMs e a membrana de colágeno tipo I/III pela contagem de células vivas e mortas no mesmo intervalo de tempo (24, 48 e 72 horas).
Resultados Em ambas as situações analisadas (AH + AD-CTM e AH + AD-CTM + membrana), o SFB apresentou a maior porcentagem de células vivas após 24, 48 e 72 horas, resultado superior ao do AH.
Conclusão A associação do AH com as AD-CTMs, com ou sem a membrana, não demonstrou superioridade na viabilidade celular quando comparado com SFB.
Prognosis in Traumatic Brain Injury
Authors: Azevedo Bruna Eduarda Civeira de , Rodrigues Igor Kunze , Mello Pedro Paulo Marchesi , Eismann Marcos Rodrigo Pereira , Sousa Daniel Santos 
Published: February 2022

Abstract
Objective To characterize the profile of TBI victims who required neurosurgical approach in two reference hospitals in the metropolitan area of Florianópolis, state of Santa Catarina, Brazil, and to identify the prognostic increase in the Pupil Reactivity Score when subtracted from the Glasgow Coma Score, found in the Glasgow-P. Additionally, to present demographic, etiological, clinical, and tomographic data, and associate them with the outcome of death.
Methods Medical record data and computed tomography (CT) scans of patients with TBI undergoing neurosurgical procedures from January 2014 to April 2019, at 2 reference hospitals in the metropolitan area of Florianópolis, state of Santa Catarina, Brazil – Hospital Regional de São José Dr. Homero de Miranda Gomes (HRSJ-HMG, in the Portuguese acronym) and Hospital Governador Celso Ramos (HGCR, in the Portuguese acronym).
Results The results of the 318 cases studied indicated that the male gender predominated (87.7%). The most affected age group was between 35 and 65 years old (47.5%). The main cause was motorcycle accidents (26.1%), followed by a fall from a height (16.4%). Most patients required admission to the intensive care unit (ICU) (85.8%), with an average duration of 13 days. The average total hospital stay was 28 days. Most cases needed external ventricular drain (EVD) (64.8%). The predominant tomographic classification was Marshall II (43.4%), followed by Marshall IV (26.1%). Most patients presented with extra-axial hematoma (64.2%), with subdural hematoma (SDH) being the most frequent (45%). Most patients presented with sequelae at hospital discharge (43.4%).
Conclusion There was no clinically relevant increase between the Glasgow and Glasgow-P scores for the tested outcomes (need for decompressive craniectomy, midline shift, presence of basal cisterns obliteration, need for ICU admission, and death).
Ovarian Tissue Culture to Preserve Fertility in Transgender Male Patients after Hormonal Treatment
Authors: Bottini Alessandra Leal , Reis Vânia Marisia Santos Fortes dos , Capp Edison , Silva Ilma Simoni Brum da , Kliemann Lúcia Maria , Corleta Helena von Eye 
Published: February 2022

Abstract
Objective To evaluate the reproductive and histological characteristics of fresh cultured ovarian tissue from transgender male patients.
Methods An in vitro pilot study in which samples were collected during sex reassignment surgery for transgender male patients. The ovarian cortex was cut into fragments of 2 mm, 3 mm, and 4 mm, and placed in a 96-well plate suitable for cultivation at days 0, 2, 4, 6, and 8, when the histology was analyzed.
Results Stromal hyperplasia was observed in all samples, and it was not associated with the obtainment of primordial or primary follicles. Peripheral reduction in cell count was also a recurrent finding. Primordial and primary follicles were identified with a heterogeneous pattern in fragments from the same patient and from different patients, and follicles in more advanced stages of development (secondary and antral) were not found. There was an association between the diameter of the ovarian fragments and the identification of primary follicles (p = 0.036). The number of days in culture was associated with histological signs of tissue damaging in the fragments (p = 0.002). The total number of follicles identified in the samples with 2 mm in diameter was significantly lower than in those that measured 4 mm in diameter (p = 0.031).
Conclusion A diameter of 4 mm is suitable for ovarian tissue culture with the benefit of ease of handling. Even after prolonged exposure to testosterone, the ovarian fragments presented primordial and primary follicles, maintaining viability throughout the days they were exposed to the culture. Freezing the ovarian cortex of transgender patients who will undergo surgery for gender reassignment would be an interesting option, in the future, for the preservation of fertility.
Prevalence of Preeclampsia in Brazil: An Integrative Review
Authors: Guida José Paulo de Siqueira , Andrade Beatriz Gadioli de , Pissinatti Luis Gabriel Ferreira , Rodrigues Bruna Fagundes , Hartman Caio Augusto , Costa Maria Laura 
Published: February 2022

Abstract
Objective To review literature and estimate the occurrence of preeclampsia and its complications in Brazil.
Methods We performed an integrative review of the literature, and included observational studies published until August 2021 on the SciELO and PubMed databases that evaluated preeclampsia among pregnant women in Brazil. Other variables of interests were maternal death, neonatal death, hemolysis, elevated liver enzymes, and low platelet count (HELLP) syndrome, and eclampsia. Three independent reviewers evaluated all retrieved studies and selected those that met inclusion criteria. A metanalysis of the prevalence of preeclampsia and eclampsia was also performed, to estimate a pooled frequency of those conditions among the studies included.
Results We retrieved 304 studies after the initial search; of those, 10 were included in the final analysis, with a total of 52,986 women considered. The pooled prevalence of preeclampsia was of 6.7%, with a total of 2,988 cases reported. The frequency of eclampsia ranged from 1.7% to 6.2%, while the occurrence of HELLP syndrome was underreported. Prematurity associated to hypertensive disorders ranged from 0.5% to 1.72%.
Conclusion The frequency of preeclampsia was similar to that reported in other international studies, and it is increasing in Brazil, probably due to the adoption of new diagnostic criteria. The development of a national surveillance network would be essential to understand the problem of hypertensive disorders of pregnancy in Brazil.
Emotional and Clinical Aspects Observed in Women with Gestational Trophoblastic Disease: A Multidisciplinary Action
Authors: França Ana Carolina Gomes , Uberti Elza Maria Hartmann , Muller Karine Paiva , Cardoso Rodrigo Bernardes , Giguer Fabiana , El Beitune Patricia , Braga Antonio 
Published: February 2022

Abstract
Objective To evaluate the emotional and clinical aspects observed in women with gestational trophoblastic disease (GTD) followed-up in a reference center (RC) by a multidisciplinary team.
Methods Retrospective cohort study of the clinical records of 186 women with GTD and of the emotional aspects (EA) observed in these women by a team of psychologists and reported by the 389 support groups conducted from 2014 to 2018.
Results The women were young (mean age: 31.2 years), 47% had no living child, 60% had planned the pregnancy, and 50% participated in two or more SG. Most women (n = 137; 73.6%) reached spontaneous remission of molar gestation in a median time of 10 weeks and had a total follow-up time of seven months. In the group of 49 women (26.3%) who progressed to gestational trophoblastic neoplasia (GTN), time to remission after chemotherapy was 18 weeks, and total follow-up time was 36 months. EA included different levels of anxiety and depression, more evident in 9.1% of the women; these symptoms tended to occur more frequently in women older than 40 years (p = 0.067), less educated (p = 0.054), and whose disease progressed to GTN (p = 0.018), as well as in those who had to undergo multi-agent chemotherapy (p = 0.028) or hysterectomy (p = 0.001) adjuvant to clinical treatment.
Conclusion This study found several EA in association with all types of GTD. It also highlights the importance of specialized care only found in a RC, essential to support the recovery of the mental health of these women.
Epistemic stance in L2 English discourse
Authors: Kizu Mika , Gyogi Eiko , Dougherty Patrick 
Published: February 2022

AbstractThis study investigates the development of pragmatic strategies in study abroad among a group of upper-intermediate to advanced second language (L2) learners studying in English as a lingua franca (ELF) context. For this purpose, their use of epistemic stance markers (EMs) was observed before, during, immediately after, and six months after their study abroad over a period of two years. An analysis of our qualitative results found significant inter-speaker variations in the use of EMs. This close analysis demonstrates that learners with lower-level speaking skills relied more on lexical verbs and adverbs when expressing their epistemic stance than those with higher-level speaking skills. This finding is in accordance with previous studies. Furthermore, our qualitative analysis of two learners demonstrates their pragmatic development through a more nuanced hedged assertion, as well as the non-linear and complex nature of their development. In addition, the pedagogical implications of this study are discussed from the ELF perspective.
Four different ways that toast can fall off a table
Authors: Cross Rod 
Published: February 2022

Abstract
It is recognised that buttered toast that falls onto its buttered side is a consequence of the laws of physics rather than a consequence of Murphy’s law. However, the physics involved is not entirely clear, given the variety of different circumstances that can cause the toast to fall. Four launch conditions are examined in this paper, using wood blocks instead of toast. The problem is a general one, in the sense that different objects (including cars and people) can fall off different surfaces for different reasons.
Periodic deformation of semiflexible colloidal chains in eccentric time-varying magnetic fields
Authors: Spatafora-Salazar Aldo , Cunha Lucas H P , Biswal Sibani Lisa 
Published: February 2022

Abstract
Elastic filaments driven out of equilibrium display complex phenomena that involve periodic changes in their shape. Here, the periodic deformation dynamics of semiflexible colloidal chains in an eccentric magnetic field are presented. This field changes both its magnitude and direction with time, leading to novel nonequilibrium chain structures. Deformation into S-, Z-, and 4-mode shapes arises via the propagation and growth of bending waves. Transitions between these morphologies are governed by an interplay among magnetic, viscous, and elastic forces. Furthermore, the periodic behavior leading to these structures is described by four distinct stages of motion that include rotation, arrest, bending, and stretching of the chain. These stages correspond to specific intervals of the eccentric field’s period. A scaling analysis that considers the relative ratio of viscous to magnetic torques via a critical frequency illustrates how to maximize the bending energy. These results provide new insights into controlling colloidal assemblies by applying complex magnetic fields.
Parametric study of laser wakefield driven generation of intense sub-cycle pulses
Authors: Siminos E , Thiele I 
Published: February 2022

Abstract
Intense sub-cycle electromagnetic pulses allow one to drive nonlinear processes in matter with unprecedented levels of control. However, it remains challenging to scale such sources in the relativistic regime. Recently, a scheme that utilizes laser-driven wakes in plasmas to amplify and compress seed laser pulses to produce tunable, carrier-envelope-phase stable, relativistic sub-cycle pulses has been proposed. Here, we present parametric studies of this process using particle-in-cell simulations, showing its robustness over a wide range of experimentally accessible laser-plasma interaction parameters, spanning more than two orders of magnitude of background plasma density. The method is shown to work with different gas-jet profiles, including structured density profiles and is robust over a relatively wide range of driver laser intensities. Our study shows that sub-cycle pulses of up to 10mJ of energy can be produced.
Photo-thermoelastic behavior of a functionally graded? Semiconductor medium excited by thermal laser pulses
Authors: Awwad E , Abouelregal Ahmed E , Atta Doaa , Sedighi Hamid M 
Published: February 2022

AbstractThis work presents an analytical approach to study the photothermal response of a functionally graded semiconducting thermoelastic half-space. The generalized thermoelastic heat conduction theory without energy dissipation is employed to extract the governing equations in which the properties of a half-space material are supposed to change in the longitudinal direction. In the context of photothermal transitional model, the interaction between heat-elastic plasma waves is described. The governing equations for the physical field variables are determined by Laplace transform procedure in the physical domain. The distribution of each field variable as well as the spread of thermo-elastic-plasma waves are plotted and discussed. Some illustrative examples are presented to determine the influence of characteristic parameters such as thermal relaxation and the power law (nonhomogeneity) index on the thermoelastic behavior of the considered medium. Finally, some interesting situations are derived from the current formulation.
Non-Gaussianity in D3-brane inflation
Authors: Marzouk Kareem , Maraio Alessandro , Seery David 
Published: February 2022

Abstract
We update predictions for observables
in the `delicate' D3/D3
inflationary model on the conifold.
We use a full CMB likelihood calculation to assess
goodness-of-fit, which is necessary because
in this model the
ζ
power spectrum often cannot be approximated as a power-law over
observable scales.
For the first time we are able to provide
accurate forecasts for
the amplitude of three-point
correlations.
In a significant portion of its parameter
space the model follows Maldacena's single-field
prediction f_NL≈ -(5/12)(ns-1)
if
|nt| ≪ 1.
Therefore
|fNL| is usually small when
the power spectrum satisfies observational
constraints.
In a small number of cases
the bispectrum is instead dominated by
effects from rapid switching between angular minima.
The resulting amplitudes are larger,
but mostly with unacceptable spectral behaviour.
In the most extreme case
we obtain |fNL
eq| ∼ 75
at kt/3 = 0.002 Mpc-1.
It has been suggested that the quasi-single
field inflation (`QSFI') mechanism could
produce significant 3-point correlations in this model.
We do observe rare shifts in amplitude between
equilateral and squeezed configurations that could
possibly be associated with QSFI effects, but
more investigation is needed to establish the full
bispectrum shape.
There is evidence of `shape' running between equilateral
and squeezed configurations that may
be inherited
from the scale dependence of the spectrum.
We explore the dependence of observables on discrete choices
such as the truncation point of the potential.
Our analysis illustrates the advantages of a standard
format for information exchange within the
inflationary model-building and testing community.