bluuebunny/crossref_metadata_2025_split huggingface dataset:
Resurgence of Omicron BA.2 in SARS-CoV-2 infection-naive Hong Kong
Authors: Xie Ruopeng , Edwards Kimberly M. , Adam Dillon C. , Leung Kathy S.M. , Tsang Tim K. , Gurung Shreya , Xiong Weijia , Wei Xiaoman , Ng Daisy Y.M. , Liu Gigi Y.Z. , Krishnan Pavithra , Chang Lydia D.J. , Cheng Samuel M.S. , Gu Haogao , Siu Gilman K.H. , Wu Joseph T. , Leung Gabriel M. , Peiris Malik , Cowling Benjamin J. , Poon Leo L.M. , Dhanasekaran Vijaykrishna 
Published: September 2022

Abstract

After keeping infections at bay for two years, Hong Kong experienced a surge of Omicron BA.2 infections in early 2022 that overwhelmed the health care system, isolation facilities, and contact tracing capacity, leading to one of the highest per-capita death rates of COVID-19 in early 2022. The outbreak occurred against a backdrop of a dense population with low immunity towards natural SARS-CoV-2 infection, high vaccine hesitancy in vulnerable populations, comprehensive disease surveillance and the capacity for stringent public health and social measures. Using genome sequences and epidemiological data from this time, we reconstruct the epidemic trajectory of the BA.2 wave, estimate transmission and incidence rates, and evaluate the effectiveness of policy changes. We identify an increase in the effective reproductive rate (Re) to 9.5 in mid-January 2022, which preceded real-time estimates of transmission (Rt), revealing that BA.2 community transmission was under-ascertained weeks before the epidemic appeared to surge in mid-February 2022. Due to this, public health measures were relaxed in early February (Spring Festival) while Re increased and remained > 1 throughout February. An independent estimation of point prevalence and incidence using phylodynamics also indicates extensive superspreading at this time, which likely contributed to the rapid expansion of the epidemic. This study demonstrates that relying on Rt estimation methods dependent on case reporting can misinform epidemic response planning, sometimes with substantial consequences. There is a need for future research and implementation of improved estimates of epidemic growth in near real-time that combine multiple disparate data sources to better inform outbreak response policy.
REDbox: a comprehensive semantic framework for data collection and management in tuberculosis research
Authors: Lima Vinícius Costa , Rijo Rui Pedro Charters Lopes , Bernardi Filipe Andrade , Filho Márcio Eloi Colombo , Júnior Francisco Barbosa , Pellison Felipe Carvalho , Galliez Rafael Mello , Kritski Afrânio Lineu , Alves Domingos 
Published: September 2022

Abstract
The outcomes of a clinical research directly depend on the correct definition of the research protocol, the data collection strategy and the data management plan. Furthermore, researchers often need to work within challenging contexts, such as in Tuberculosis services, where human and technological resources for research may be rare. The use of Electronic Data Capture systems, such as REDCap and KoBotoolbox, can help to mitigate such risks and to enable a reliable environment to conduct health research and promote results dissemination and data reusability. The proposed solution was based on needs pinpointed by researchers, considering the lack of an embracing solution to conduct research in low resources environments. The REDbox framework was built to enhance collection, management, sharing and availability of data in tuberculosis research, while providing a better user experience. The relevance of this article lies in the innovative approach to support TB research by combining existing technologies and tailored supporting features. REDbox was implemented as a valuable asset in nationwide cross-institutional Tuberculosis research projects in Brazil.
TLR7/8-agonist loaded M1 Macrophagederived nanovesicles promote the polarization of macrophages to enhance bladder cancer immunotherapy
Authors: Zhang Qing , Lin Tingsheng , Zhang Wenlong , Ding Yuanzhen , Wang Xiaofeng , He Xin , Lu Wenfeng , Cao Wenmin , Wang Tingzheng , Chen Wei , Guo Hongqian 
Published: September 2022

Abstract
Immune checkpoint inhibitors (ICIs), such as PD-1/PD-L1 antibodies, have been successfully used to modulate the cancer killing function of immune cells in the tumor microenvironment (TME). However, in bladder cancer, the level of the proinflammatory M1 macrophages were significantly low than the immunosuppressive M2 macrophages. The abundant of M2 macrophages released cytokines to induce the resistance of ICIs treatment and alleviate immune cell attack, finally resulting in promoting tumor growth. To enhance the bladder cancer immunotherapy, nanovesicles derived from M1 macrophages (M1 NV) was applied to load the TLR7/8 agonist of R848, a potent driver of M1 macrophages, for constructing M1 NV-R848. The results revealed M1 NV-R848 could more effectively induce polarization of M2 macrophages into M1 macrophages when compared to M1 NV or R848 alone both in vitro and in vivo. In addition, intravenous injection of M1 NV-R848 would improve the immunosuppressive TME by upregulation of proinflammatory M1 macrophages, improvement of CD8+T cells infiltration, finally enhancing the immunotherapy of PD-L1 antibodies with good biocompatibility in bladder cancer bearing mouse model. Thus, our study demonstrates that M1 NV-R848 could serve as a potential strategy to improve the polarization of M1 macrophages in bladder cancer, which might be further used for other cancer with the immunosuppressive TME.
Analysis of Volumetric Perfusion Quantitative Parameters Using
CS-VIBE Breast Dynamic Contrast Enhanced MR Imaging
Authors: Chang Yun-Woo , Lee Eun Ji , Hwang Jiyoung , Nickel Dominik , Sung Jae Kon 
Published: September 2022

Purpose:
To evaluate the diagnostic performance of three-dimensional volume of interest (3D-VOI) perfusion quantitative parameters using CS-VIBE DCE-MRI, and investigate the relationship of the prognostic factors.

Patients and Methods:
The volumetric perfusion quantitative parameters of Ktrans, Kep, Ve, Vp, of 124 pathologically proven breast masses in 93 patients were obtained using the two-compartment extended Tofts model. Also, the perfusion parameters of AUC, TTP, Emax, wash-in, and washout were automatically calculated using post-processing software. The relationship between the perfusion quantitative parameters and lesion size, pathology, and prognostic factors of malignancy was evaluated.

Results:
Ktrans and Kep were significantly higher in the malignant than the benign lesions (p < 0.001), and the AUROC of Ktrans and Kep were 0.802 and 0.815, respectively. The area under DCE curve, TTP, Emax, wash-in, and wash-out were significantly different between the benign and malignant lesion (p < 0.05). In multiple linear regression analysis, Ktrans and Kep were significantly different between benign and malignant tumors. Malignant tumors larger than 2cm were significantly different from those smaller than 2cm in Ktrans, Kep, Vp, area under DCE curve, TTP, Emax, and wash-in values (p < 0.05). TTP was significantly lower in higher Ki-67 index (p < 0.05).

Conclusion:
Perfusion quantitative parameters may be applied as a feasible imaging biomarker to discriminate malignant from benign tumors. In malignant lesions, perfusion parameters were not associated with histopathological results, but only in tumor size.
Anti-Cancer Activity of Synthesized 5-Benzyl juglone on Selected Human Cancer Cell
Lines
Authors: Wang Chenhao , Hu Yuqi , Sun Yang , Xiang Shouyan , Qian Jiajun , Liu Zhizhuo , Ji Yufeng , Cai Chenglin , Sun Gege , Cui Jiahua 
Published: September 2022

Background:
Cancer is a malignant disease that causes millions of deaths each year worldwide. As one of
the cancer therapeutic strategies, chemotherapy is a means to destroy rapidly dividing cells. The main problem with
cancer chemotherapy is the lack of selectivity of conventional chemotherapeutic drugs, leading to toxicity towards
normal cells. Therefore, the discovery of anti-cancer agents with selectivity for fast-growing cancer cells is desirable.

Objective:
In this study, we report the synthesis and identification of synthesized 5-benzyl juglone as a potential anticancer
agent with selectivity toward certain cancer cell lines.

Methods:
An efficient synthetic method for 5-benzyl juglone was established. The proliferation of cancer cell lines and
a normal cell line treated by the target compound was studied using an MTT assay. In addition, the cell cycle arrest and
apoptosis were determined by flow cytometry.

Results:
Based on the Diels-Alder (D-A) reaction between 3,6-dimethoxy benzyne intermediate and furan, further
acid-catalyzed intramolecular rearrangement, and CAN-mediated oxidation, a convenient synthesis of 5-benzyl juglone
was achieved with high overall yield. The results from in vitro biological evaluation indicated that the juglone derivative
exhibited potent antiproliferative activity against HCT-15 human colorectal cancer cells with an IC50 value of
12.27 μM. It exerted high inhibitory activity toward MCF-7 human breast cancer cells and, to a much lesser extent, to
corresponding MCF-10A human breast epithelial normal cells with an IC50 ratio (IC50 in MCF-7 divided by IC50 in
MCF-10A) of 0.62.

Conclusion:
The mechanistic investigations indicated that 5-benzyl juglone could induce cell cycle arrest at the G0/G1
phase and promote apoptosis of HCT-15 cells. The apoptotic effects possibly contributed to its higher selectivity toward
cancer cells than normal cell lines.
Key Technologies of Data Security and Privacy Protection in the Internetof- Things Group Intelligence Perception
Authors: Bhola Jyoti , Wu Hao , Neware Rahul , Eswaran Sathyapriya 
Published: September 2022

Aim:To study the key technology of privacy protection and data security in the Internet of Things group intelligence perception, a cryptographic-based technology was proposed.Background:First, the background of group intelligence perception and three existing problems were briefly introduced, and the inherent contradictions among the three problems, which led to some challenges in this study, were reported.Objective:A network model, a security model, and design goals were constructed, and the solution based on cryptography-related technology was proposed.Method:The security and cost complexity of the proposed solution was theoretically analysed. The calculation cost of mobile phone measurement verified the practical feasibility of the scheme.Results:When ɛ was considerably small, both false positive (FP) and false negative (FN) were small (close to 0). With an increase in ɛ, the FP rate increased, and the FN rate became 0. When ɛ = 0.5, the FP rate was only 0.1, and the equivalent FN rate was 0 after the user completed 50 tasks. The trust model used was highly accurate.Conclusions:This study has great significance to promote the safe and reliable application development to ensure the genuineness and trustworthiness of data in the aggregation of intermediate data and back-end data services.
Тетрагональные нанокристаллические фазы в оксидах Re-=SUB=-2-=/SUB=-O-=SUB=-3-=/SUB=-
Authors: Шмытько И.М. , Кедров В.В. 
Published: September 2022

Проведены рентгеновские дифрактометрические исследования структурного состояния простых редкоземельных оксидов Gd2O3, Sm2O3 и Eu2O3, синтезированных разными методами, на первых этапах кристаллообразования. Обнаружено, что первой кристаллической фазой этих соединений в нанокристаллическом состоянии является не известная кубическая модификация с пространственной группой симметрии S.G. Ia-3 (206), а тетрагональные фазы, пространственные группы которых не установлены в силу малого количества сильных рефлексов в наносостоянии. Показано также, что такие же тетрагональные фазы образуются в промышленных порошках этих соединений, подвергнутых длительному хранению. Ключевые слова: синтез Re2O3, глицин-нитратный метод, нанокристаллическое состояние, рентген-дифракционные методы исследования, фазовые переходы.
Salinity Effect of Nutrient Solution on Maradol papaya
Authors: Aguilar-Bautistaa Aracely , Alejo-Santiago Gelacio , Aburto-González Circe Aidín , Juárez-Rosete Cecilia R. , Bugarín-Montoya Rubén , López-Guzmán Graciela Guadalupe , García-Herrera Tania 
Published: September 2022

Papaya (Carica papaya L.) is a crop of great economic importance. It is the fourth most produced tropical fruit in the world. The most substantial problems faced during its production are pests and diseases, which is why it has been planted under greenhouse conditions. However, it is required that the plants not be of great height not to need tall greenhouses. Therefore, this research aims to evaluate to the salinity effect and identify nutritive solutions that reduce plant height. The experimental design was completely randomized with four treatments and ten replications. The treatments were four concentrations of Steiner nutrient solution (50 %, 100 %, 150 %, and 200 %) in whose composition are anions (phosphate, nitrate, and sulfate) and cations (potassium, calcium, and magnesium), thus generating electrical conductivity of 1.0, 2.0, 3.0, and 4.0 dS/m, respectively. The variables evaluated were plant height, number of leaves, stem diameter, foliar area, chlorophyll a and b concentration, proline content, and foliar nutrient concentration. The nutrients comprise nitrogen, phosphorus, potassium, calcium, and magnesium. The analysis of variance indicated significant differences in all variables except magnesium concentration. As salinity increased, plant height, number of leaves, stem diameter, leaf area, phosphorus, potassium, and calcium decreased, but chlorophyll a and b concentration, proline content, and nitrogen increased. We conclude that Steiner nutrient solution with 4.0 dS/m (200 %) can reduce plant height to grow it in greenhouses.
Design and Evaluation Challenges of Conversational Agents in Health Care and Well-being: Selective Review Study
Authors: Kocaballi Ahmet Baki , Sezgin Emre , Clark Leigh , Carroll John M , Huang Yungui , Huh-Yoo Jina , Kim Junhan , Kocielnik Rafal , Lee Yi-Chieh , Mamykina Lena , Mitchell Elliot G , Moore Robert J , Murali Prasanth , Mynatt Elizabeth D , Park Sun Young , Pasta Alessandro , Richards Deborah , Silva Lucas M , Smriti Diva , Spillane Brendan , Zhang Zhan , Zubatiy Tamara 
Published: September 2022

Background
Health care and well-being are 2 main interconnected application areas of conversational agents (CAs). There is a significant increase in research, development, and commercial implementations in this area. In parallel to the increasing interest, new challenges in designing and evaluating CAs have emerged.

Objective
This study aims to identify key design, development, and evaluation challenges of CAs in health care and well-being research. The focus is on the very recent projects with their emerging challenges.

Methods
A review study was conducted with 17 invited studies, most of which were presented at the ACM (Association for Computing Machinery) CHI 2020 conference workshop on CAs for health and well-being. Eligibility criteria required the studies to involve a CA applied to a health or well-being project (ongoing or recently finished). The participating studies were asked to report on their projects’ design and evaluation challenges. We used thematic analysis to review the studies.

Results
The findings include a range of topics from primary care to caring for older adults to health coaching. We identified 4 major themes: (1) Domain Information and Integration, (2) User-System Interaction and Partnership, (3) Evaluation, and (4) Conversational Competence.

Conclusions
CAs proved their worth during the pandemic as health screening tools, and are expected to stay to further support various health care domains, especially personal health care. Growth in investment in CAs also shows the value as a personal assistant. Our study shows that while some challenges are shared with other CA application areas, safety and privacy remain the major challenges in the health care and well-being domains. An increased level of collaboration across different institutions and entities may be a promising direction to address some of the major challenges that otherwise would be too complex to be addressed by the projects with their limited scope and budget.
FAIRification as a Team Sport
Authors: Sansone Susanna-Assunta 
Published: September 2022

The FAIR Principles have succeeded to unit stakeholders world-wide behind a common concept: good data management under common standards. However, putting FAIR into practice is still work in progress and it "takes a village". I will provide an overview of two community-driven resources, the FAIRsharing (https://fairsharing.org) and the FAIR Cookbook (https://faircookbook.elixir-europe.org), as examples of what we need to turn FAIR into reality. Both resources will also contribute to the UKRN ecosystem.
The Impact of Augmented Reality (AR) Books on the Reading Engagement and Comprehension of Child Readers.
Authors: Alhamad Kawla Abdullah , MANCHES Andrew , MCGEOWN Sarah 
Published: September 2022

Augmented Reality (AR) books offer new opportunities for interaction and engagement, and additional features provide potential to support children’s reading comprehension, yet there is currently very little research in this area. This project aims to capture and understand children’s (aged 7-10) experiences with AR books, specifically focusing on whether there are benefits to reading engagement and comprehension. A particular focus will be on understanding whether, to what extent, and how, AR books have potential to support and engage struggling readers. This poster describes the protocol for study 1 of the project (pre-registration here https://osf.io/9q678)
Opportunity sampling will be used to recruit up to four primary school teachers and 30 children (aged 7-10) from 3-4 classrooms from 1-2 Scottish primary schools. Twelve groups of students from different year groups (with 1-3 children in each group) will be observed participating in an AR reading session. Students will be observed interacting naturally with the AR book (printed book, with tablet affording AR features), with the support of an adult (if required) and will be audio recorded and observed during this time. During the observation written (anonymized) notes will also be made in relation to key points (e.g., usability, enjoyment, engagement, discussion etc).
Following this, children will be interviewed by the researcher and asked about their engagement and comprehension of the AR book and their perceptions of the similarities and differences (positive and negative) between AR books and traditional print books. In addition, all class teachers (n = ~4) will be interviewed to explore their perceptions of AR books in terms of supporting reading engagement and comprehension and their perceptions regarding usability of AR books in the classroom.
Thematic analysis will be used to identify and report themes related to child readers interaction, experiences and perceptions (engagement and comprehension) of AR books, and teachers’ perceptions of AR books. The six phases outlined in Braun & Clarke (2006) will be applied.
Pre-registration has been used for this project as it facilitates a shared understanding of my project, as a PhD researcher, with my supervisors and the wider research community. It ensures I clearly articulate my research questions and related methods prior to conducting the research. Furthermore, it prompts me to consider credibility strategies prior to starting data collection or analysis. Finally, it provides readers with an opportunity to learn about my research at any early stage and understand how research evolves across the different phases.
Factors Associated With Discordant A1C-Estimated and Measured Average Glucose Among Hospitalized Patients With Diabetes
Authors: Wallam Sara , S. Abusamaan Mohammed , Clarke William , Mathioudakis Nestoras 
Published: September 2022

<p> </p>
<p>In this retrospective analysis, we explored the correlation between measured average glucose (mAG) and A1C-estimated average glucose (eAG) in hospitalized patients with diabetes and to describe factors associated with discordant mAG and eAG at the transition from home to hospital. Having mAG lower than eAG was associated with Black race, Other race, increasing length of stay, community hospital setting, surgery, fever, metformin use, certain inpatient diets, home antihyperglycemic treatment, and coded type 1 or type 2 diabetes. Having mAG higher than eAG was associated with certain discharge services (e.g., intensive care unit), higher BMI, hypertension, tachycardia, higher albumin, higher potassium, anemia, inpatient glucocorticoid use, and treatment with home insulin, secretagogues, and glucocorticoids. These factors should be considered when using patients’ A1C as an indicator of outpatient glycemic control to determine the inpatient antihyperglycemic regimens. </p>
Farklı dillerdeki metinler üzerinde yapılan duygu analizi çalışmalarının incelenmesi
Authors: KILIÇER Seda , SAMLI Ruya 
Published: September 2022

Teknolojinin gelişmesiyle birlikte veri miktarı hızlı bir şekilde artmaktadır ancak bu veriler işlenmediği sürece bir anlam ifade etmemektedir. Bu sebeple bu büyük verilerin sistemler aracılığıyla hızlı bir şekilde bilgiye dönüştürülmesi ve insanlar tarafından kullanılabilir hale dönüştürülebilmesi hedeflenmektedir.
Duygu analizi, bir metnin olumlu, olumsuz veya nötr gibi duygulardan hangisine daha yakın olduğunun sonucunun farklı yöntemler kullanılarak elde edilmesidir. Bu çalışmada son on yılda (2013-2022) yapılan duygu analizi çalışmaları ele alınmış, değerlendirilmiş ve sınıflandırılmıştır. Bu amaçla sözlük tabanlı yaklaşım, makine öğrenmesi yaklaşımı ve hibrit yaklaşım yöntemleri kullanılarak duygu analizi yapılan 68 çalışma incelenmiştir. Çalışmalar ilk olarak duygu analizinde kullanılan yöntemlere göre, sonrasında verilerin elde edilme şekillerine ve incelenen metnin diline göre sınıflandırılmıştır. Bunlar dışında duygu analizinde kullanılan yöntemlere göre uygulanan adımlar detaylı olarak incelenmiştir. Duygu analizi çalışmalarında elde edilen başarı oranlarının artırılabilmesi için incelenen çalışmalar tablolar aracılığıyla karşılaştırılmıştır. Her yöntem kendi içerisinde değerlendirilerek daha başarılı sonuçlar elde edilebilmesi için incelenen kriterler ve elde edilen sonuçlar arasındaki bağlantılar araştırılmıştır
Respon Al-Qur’an tentang Permasalahan Seputar Gender
Authors: Syofrianisda Syofrianisda 
Published: September 2022

Pembicaraan mengenai isu gender sudah banyak dikumandangkan baik dikalangan umum maupun di kalangan akademisi khususnya di Indonesia. Fokus pembicaraan ada yang bersifat umum, terutama menyangkut hak-hak dan pemberdayaan perempuan. Dan, ada yang bersifat khusus, termasuk dalam pemikiran Islam, yaitu penafsiran ayat-ayat terkait masalah perempuan. Beberapa kritikan terhadap perspektif gender dalam Al-Qur’an, umumnya dialamatkan kepada penafsiran tentang teks-teks tersebut oleh beberapa mufassir yang dinilai bersikap diskriminatif terhadap perempuan. Pemahaman mengenai sejauh mana obketivitas dan kejernihan kritikan tersebut, dapat dilakukan dengan memahami terlebih dahulu mengenai makna gender, kemudian menelusurinya lewat penafsiran Al-Qur’an dan Sunnah. Dari pembahasan ini dapat disimpulkan bahwa esensi dari respon Al-Qur’an terhadap permasalahan gender adalah ide tentang adanya kesetaraan gender antara laki-laki dan perempuan. Ide kesetaraan tersebut sudah tentu harus sesuai dengan prinsip dasar agama Islam sebagai rahmatan lil alamin, yang berarti juga termasuk rahmat bagi perempuan tanpa terpasung hak-haknya hanya dikarenakan berjenis kelamin perempuan