bluuebunny/crossref_metadata_2025_split huggingface dataset:
Outcomes of paediatric patients who are not transported to hospital by Emergency Medical Services: a data linkage study
Authors: Nehme Emily , Nehme Ziad , Cox Shelley , Smith Karen 
Published: October 2022

BackgroundData on the safety of non-transport decisions for paediatric patients attended by Emergency Medical Services (EMS) are lacking. We describe the characteristics and outcomes of paediatric non-transported patients in Victoria, Australia.MethodsA retrospective data linkage study of consecutive paediatric (aged <18 years) non-transported patients between January 2015 and June 2019. Patients were linked to ED, hospital admission and death records. Multivariable logistic regression analyses were used to determine factors associated with EMS recontact, ED presentation, hospital admission and an adverse event (death/cardiac arrest, intensive care unit admission or highest ED triage category) within 48 hours of the initial emergency call.ResultsIn total, 62 975 non-transported patients were included. The mean age was 7.1 (SD 6.0) years and 48.9% were male. Overall, 2.2% recontacted the EMS within 48 hours, 13.7% self-presented to a public ED, 2.4% were admitted to hospital and 0.1% had an adverse event, including two deaths. Among patients with paramedic-initiated non-transport (excluding transport refusals and transport via other means), 5.6% presented to a public ED, 1.1% were admitted to hospital and 0.05% had an adverse event. In the overall population, an abnormal vital sign on initial assessment increased the odds of hospital admission and an adverse event. Among paramedic-initiated non-transports, cases occurring in the early hours of the morning (04:00–08:00 hours) were associated with increased odds of subsequent hospital admission, while the odds of ED presentation and hospital admission also increased with increasing prior exposure to non-transported cases.ConclusionAdverse events were rare among paramedic-initiated non-transport cases. Vital sign derangements and attendance by paramedics with higher prior exposure to non-transports were associated with poorer outcomes and may be used to improve safety.
Towards the prevention of sexually transmitted infections (STIs): Healthcare-seeking behaviour of women with STIs or STI symptoms in sub-Saharan Africa
Authors: Seidu Abdul-Aziz , Aboagye Richard Gyan , Okyere Joshua , Adu Collins , Aboagye-Mensah Richard , Ahinkorah Bright Opoku 
Published: October 2022

ObjectiveSexually transmitted infections (STIs) constitute major public health problems because of their prevalence and contribution to mortality and morbidity worldwide. Healthcare seeking for STIs plays a significant role in the global prevention of STIs. We examined the prevalence and factors associated with healthcare seeking for STIs or STI symptoms among women in sub-Saharan Africa (SSA).MethodsData on 38 394 women of reproductive age from the most recent Demographic and Health Surveys of 28 countries in SSA were analysed. Percentages were used to summarise the prevalence of healthcare seeking for STIs or STIs symptoms. The factors associated with healthcare seeking for STIs or STI symptoms were examined using multilevel binary logistic regression analysis. We presented the results using adjusted odds ratios (aORs) with 95% confidence intervals (CIs).ResultsOverall, the proportion of women with STIs or STI symptoms who sought healthcare was 66.1%, with the highest and lowest proportion found in Liberia (85.6%) and Ethiopia (37.9%) respectively. The likelihood of seeking healthcare for STIs or STI symptoms increased with increasing wealth quintile and level of education. Working women, older women, cohabiting women, women with comprehensive HIV/AIDS knowledge, women exposed to mass media, those who had no barrier to healthcare access, and those covered by health insurance had greater odds of seeking treatment for STIs or STI symptoms. On the contrary, the odds of seeking treatment for STIs or STI symptoms was lower among married women and women who lived in rural areas.ConclusionThe findings of the study call for strengthening of policies, programmes, and interventions geared towards improving thehealthcare-seeking behaviour of women with STIs, taking into consideration the factors identified in this study.
Exotic molecular meson states of $$B^{(*)} K^{(*)}$$ nature
Authors: Oset E. , Roca L. 
Published: October 2022

AbstractWe evaluate theoretically the interaction of the open bottom and strange systems$${{\bar{B}}}{{\bar{K}}}$$B¯K¯,$${{\bar{B}}^*}{{\bar{K}}}$$B¯∗K¯,$${{\bar{B}}}{{\bar{K}}^*}$$B¯K¯∗and$${{\bar{B}}^*}{{\bar{K}}^*}$$B¯∗K¯∗to look for possible bound states which could correspond to exotic non-quark–antiquark mesons since they would contain at least oneband onesquarks. The s-wave scattering matrix is evaluated implementing unitarity by means of the Bethe–Salpeter equation, with the potential kernels obtained from contact and vector meson exchange mechanisms. The vertices needed are supplied from Lagrangians derived from suitable extensions of the hidden gauge symmetry approach to the bottom sector. We find poles below the respective thresholds for isospin 0 interaction and evaluate the widths of the different obtained states by including the main sources of imaginary part, which are the$$B^*\rightarrow B\gamma $$B∗→Bγdecay in the$${{\bar{B}}^*}{{\bar{K}}}$$B¯∗K¯channels, the$$K^*\rightarrow K \pi $$K∗→Kπin the channels involving a$$K^*$$K∗, plus the box diagrams with$${{\bar{B}}}{{\bar{K}}}$$B¯K¯and$${{\bar{B}}^*}{{\bar{K}}}$$B¯∗K¯intermediate states for the$${{\bar{B}}^*}{{\bar{K}}^*}$$B¯∗K¯∗channels.
Endothelial RBPJ Is Essential for the Education of Tumor-Associated Macrophages
Authors: Alsina-Sanchis Elisenda , Mülfarth Ronja , Moll Iris , Böhn Sarah , Wiedmann Lena , Jordana-Urriza Lorea , Ziegelbauer Tara , Zimmer Eleni , Taylor Jacqueline , De Angelis Rigotti Francesca , Stögbauer Adrian , Giaimo Benedetto Daniele , Cerwenka Adelheid , Borggrefe Tilman , Fischer Andreas , Rodriguez-Vita Juan 
Published: October 2022

Abstract

Epithelial ovarian cancer (EOC) is one of the most lethal gynecologic cancers worldwide. EOC cells educate tumor-associated macrophages (TAM) through CD44-mediated cholesterol depletion to generate an immunosuppressive tumor microenvironment (TME). In addition, tumor cells frequently activate Notch1 receptors on endothelial cells (EC) to facilitate metastasis. However, further work is required to establish whether the endothelium also influences the education of recruited monocytes. Here, we report that canonical Notch signaling through RBPJ in ECs is an important player in the education of TAMs and EOC progression. Deletion of Rbpj in the endothelium of adult mice reduced infiltration of monocyte-derived macrophages into the TME of EOC and prevented the acquisition of a typical TAM gene signature; this was associated with stronger cytotoxic activity of T cells and decreased tumor burden. Mechanistically, CXCL2 was identified as a novel Notch/RBPJ target gene that regulated the expression of CD44 on monocytes and subsequent cholesterol depletion of TAMs. Bioinformatic analysis of ovarian cancer patient data showed that increased CXCL2 expression is accompanied by higher expression of CD44 and TAM education. Together, these findings indicate that EOC cells induce the tumor endothelium to secrete CXCL2 to establish an immunosuppressive microenvironment.

Significance:
Endothelial Notch signaling favors immunosuppression by increasing CXCL2 secretion to stimulate CD44 expression in macrophages, facilitating their education by tumor cells.
Therapy-related Myeloid Neoplasms Following PARP Inhibitors: Real-life Experience
Authors: Marmouset Vincent , Decroocq Justine , Garciaz Sylvain , Etienne Gabriel , Belhabri Amine , Bertoli Sarah , Gastaud Lauris , Simand Célestine , Chantepie Sylvain , Uzunov Madalina , Genthon Alexis , Berthon Céline , Chiche Edmond , Dumas Pierre-Yves , Vargaftig Jacques , Salmeron Géraldine , Lemasle Emilie , Tavernier Emmanuelle , Delage Jérémy , Loirat Marion , Morineau Nadine , Blanc-Durand Félix , Pautier Patricia , Vergé Véronique , Auger Nathalie , Thomas Myrtille , Stefani Laetitia , Lepelley Marion , Boyer Thomas , Thepot Sylvain , Gourin Marie-Pierre , Bourquard Pascal , Duchmann Matthieu , Morice Pierre-Marie , Michallet Mauricette , Adès Lionel , Fenaux Pierre , Récher Christian , Dombret Hervé , Pagès Arnaud , Marzac Christophe , Leary Alexandra , Micol Jean-Baptiste ,   on behalf of UNIHEM, French Network of Pharmacovigilance Centers, ALFA, FILO, and GFM
Published: October 2022

Abstract

Purpose:
To provide insights into the diagnosis and management of therapy-related myeloid neoplasms (t-MN) following PARP inhibitors (PARPi).

Experimental Design:
In a French cancer center, we identified and described the profiles of 13 t-MN diagnosed among 37 patients with ovarian cancer referred to hematology consultation for cytopenia under PARPi. Next, we described these 13 t-MN post-PARPi among 37 t-MN post ovarian cancer according to PARPi exposure. Finally, we described 69 t-MN post-PARPi in a national cohort.

Results:
From 2016 to 2021, cumulative incidence of t-MN was 3.5% (13/373) among patients with ovarian cancer treated with PARPi. At time of hematologic consultation, patients with t-MN had a longer PARPi exposure (9 vs. 3 months, P = 0.01), lower platelet count (74 vs. 173 G/L, P = 0.0005), and more cytopenias (2 vs. 1, P = 0.0005). Compared with t-MN not exposed to PARPi, patients with t-MN-PARPi had more BRCA1/2 germline mutation (61.5% vs. 0%, P = 0.03) but similar overall survival (OS). In the national cohort, most t-MN post-PARPi had a complex karyotype (61%) associated with a high rate of TP53 mutation (71%). Median OS was 9.6 months (interquartile range, 4–14.6). In multivariate analysis, a longer time between end of PARPi and t-MN (HR, 1.046; P = 0.02), olaparib compared with other PARPi (HR, 5.82; P = 0.003) and acute myeloid leukemia (HR, 2.485; P = 0.01) were associated with shorter OS.

Conclusions:
In a large series, we described a high incidence of t-MN post-PARPi associated with unfavorable cytogenetic and molecular abnormalities leading to poor OS. Early detection is crucial, particularly in cases of delayed cytopenia.
Joint High Level of Oxidized Low‐Density Lipoprotein and High‐Sensitivity C‐Reactive Protein are Associated With Recurrent Stroke and Poor Functional Outcome in Minor Stroke or Transient Ischemic Attack
Authors: Xu Qin , Wu Qiong , Li Hao , Tian Xue , Zuo Yingting , Zhang Yijun , Zhang Xiaoli , Lin Yongzhong , Wu Yiping , Wang Yongjun , Wang Anxin , Meng Xia 
Published: October 2022

Background
Oxidized low‐density lipoprotein (oxLDL) and hs‐CRP (high‐sensitivity C‐reactive protein) plays an important role in cardiovascular diseases though inflammation and oxidative stress, etc. However, evidence on their combined effects on stroke prognosis is still limited. We aimed to explore the joint association of oxLDL and hs‐CRP with outcomes of minor stroke or transient ischemic attack.

Methods and Results

A subgroup of 3019 patients from the CHANCE trial (Clopidogrel in High‐Risk Patients With Acute Nondisabling Cerebrovascular Events) were analyzed. Baseline oxLDL and hs‐CRP levels were measured. The primary outcome was any stroke within 90 days. The secondary outcomes included any stroke within 1 year, and ischemic stroke, combined vascular events, and poor functional outcomes (modified Rankin Scale 2–6 or 3–6) at 90 days and 1 year. Vascular events outcomes were analyzed with Cox proportional hazards and poor functional outcomes with logistic models. Elevated oxLDL (>28.81 μg/dL) and hs‐CRP (>4.20 mg/L) was observed in 624 (20.67%) of the 3019 patients. Patients with oxLDL >28.81 μg/dL and hs‐CRP >4.20 mg/L had a higher risk of recurrent stroke within 90 days (adjusted hazard ratio, 1.52; 95% CI, 1.17–1.97), compared with those with oxLDL ≤28.81 μg/dL and hs‐CRP ≤4.20 mg/L, after adjusting relevant confounding factors (
P
=0.002). Similar results were observed for secondary outcomes (
P
<0.05 for all).

Conclusions
In patients with minor stroke or transient ischemic attack, joint high levels of oxLDL and hs‐CRP was associated with increased risk of recurrent stroke, combined vascular events, and poor functional outcome.
Marking Segulah in the Illuminated Bibles of Jewish Iberia
Authors: Harris Julie A. 
Published: October 2022

Abstract
The power ascribed to the Bible codex was expressed by the word Segulah, which in biblical Hebrew translates as “treasured possession.” In the later Middle Ages, however, this word is better translated as “remedy” or “occult virtue,” reflecting an infusion of medical and magical concepts which can be seen to align with ideas present in writings about Torah study by Profiat Duran (Ma’aseh Efod, 1403). This article finds visual evidence for a multi-faceted understanding of Segulah in the Seder marks which were added to the thirteenth-century Iberian Bible known as the Damascus Keter (JNUL 4 790).
Recreating Victory: Liturgy, Crusade Propaganda, and Simulacrum in Milan, CE 1100
Authors: Shagrir Iris 
Published: October 2022

Abstract
A feast commemorating the conquest of Jerusalem was celebrated in Milan, on 15 July 1100. On that day, an existing Milanese church was rededicated as the “Church of the Holy Sepulchre.” The elaborate ceremony included a procession, an octave, and a pilgrims’ indulgence, along with crusade propaganda. It was perhaps the earliest one celebrated in Western Europe in the wake of the Jerusalem conquest of 15 July 1099, added to the liturgical calendar of Milan. The event was carefully orchestrated by Anselm of Buis, the archbishop of Milan – a supporter of the church reform movement and close ally of Pope Urban II. The feast was attended by the local community, among them First Crusaders returning from Jerusalem. This article focuses on the innovative nature of the Milanese feast, its liturgy and possible link with the celebration in Jerusalem a year earlier. It also considers the triumphal recreation of Jerusalem in Lombardy within the western tradition of imitations of Jerusalem.
Seemings and the Response to Radical Skepticism
Authors: Lemos Noah 
Published: October 2022

Abstract
I begin by making some brief remarks about commonsense particularism. Commonsense particularists hold that we know pretty much what we think we know and hold that some of these beliefs are more reasonable than competing skeptical principles. However, commonsense philosophers often differ about what justifies these particular beliefs. Michael Bergmann holds that that our commonsense epistemic beliefs depend for their justification on epistemic intuitions or epistemic seemings. After a brief description of his views, I raise some questions about the nature and epistemic role of these epistemic seemings.
Love and the Brethren of Purity: A Comparative Study of Human Intimacy in Islamic Philosophy
Authors: Toosi Javad Fakhkhar , Virani Shafique N. 
Published: October 2022

Abstract
This article is a study of the Brethren of Purity’s thirty-seventh epistle, The Essence of Love. It compares this work with the treatises on love written by the Muslim philosophers Ibn Sīnā, Suhrawardī, and Mullā Ṣadrā, the leading representatives of the Peripatetic, Illuminationist, and Transcendental schools of Islamic philosophy, respectively. A fundamental distinction of the Brethren’s approach is their positive impression of love between human beings, including its romantic and conjugal components. Such love is not entirely under human control; the celestial spheres also exercise their influence. The Brethren contend that society and civilization prosper because of love. Unlike several others, they are intent on reconciling divine or “real” love with love between individuals. While the Brethren praise the benefits of romantic love and conjugal relations, Ibn Sīnā judges them harmful, and Suhrawardī a distraction. Mullā Ṣadrā, though, takes an intermediate position, influenced by both the Brethren and Ibn Sīnā.
Music, Prayer, and “Something Understood”
Authors: Peralta Camilo 
Published: October 2022

Abstract
During the Middle Ages, Christian theologians developed various means for addressing God’s ineffable, or indescribable, nature. One could, for instance, employ apophatic or “negative” theology, or use music and prayer as metaphors for the harmony of the universe and our relationship with Him. This paper examines the use of these and other approaches to the ineffable by the French indiciare Jean Molinet and the English poet George Herbert. Despite being written hundreds of years apart and in different languages, Molinet’s Chroniques (1474–1504) and Herbert’s “Prayer (I)” (1633) both rely on a series of impressionistic metaphors to convey something of the ineffability of their respective subjects (music and prayer). In their efforts to describe that which is difficult, if not impossible, to capture in words, both turn to the long tradition of Christian mysticism, and in particular the works of Pseudo-Dionysius and Boethius.
Dark Caravaggism
Authors: Ch’ien Letha 
Published: October 2022

Abstract
Many of Caravaggio’s late istoria altarpieces differ from what is commonly called Caravaggism (the artist’s pictorial mode during his Roman period) strongly enough that together the paintings form a distinctive approach to istoria that requires its own term: Dark Caravaggism. This paper identifies and analyzes this second Caravaggism, a pictorial mode as innovative as the first, but one that has been neglected in the literature. In the Resurrection of Lazarus, Burial of St. Lucy, and other works including the Death of the Virgin and Beheading of St. John, Caravaggio extends narrative moments in even muted palettes, stilled movement, and cavernous spaces. These paintings command the viewer’s attention by employing the eye’s physiological process of dark adaption in which the eye adjusts over time to dim light conditions. Eschewing Early Caravaggism’s instantaneity and fragmented tenebrism, Dark Caravaggism asks the viewer for quiet meditation rather than frantic search. If not for the artist’s untimely death at age 38, late Caravaggism likely would have produced a second revolution in European painting on par with the first.
Oficanthon Paulian, 1985, a junior synonym of Lepanus Balthasar, 1966 (Coleoptera: Scarabaeidae: Scarabaeinae), with redescription of Lepanus mirabilis (Paulian, 1985)
Authors: GUNTER NICOLE L. , SAXTON NATALIE A. , WEIR THOMAS A. 
Published: October 2022

The monotypic genus Oficanthon Paulian, 1985 (Coleoptera: Scarabaeidae: Scarabaeinae) is treated as a junior synonym of the genus Lepanus Balthasar, 1966, and L. mirabilis (Paulian, 1985), new combination is proposed for Oficanthon mirabilis Paulian, 1985. Both morphological and molecular evidence support this synonymy. Morphological evidence further supports its placement within the Lepanus ustulatus species group. Lepanus mirabilis is redescribed.
On Variability due to Local Minima and K-Fold Cross Validation
Authors: Marzban Caren , Liu Jueyi , Tissot Philippe 
Published: October 2022

Abstract
Resampling methods such as cross validation or bootstrap are often employed to estimate the uncertainty in a loss function due to sampling variability, usually for the purpose of model selection. In models that require nonlinear optimization, however, the existence of local minima in the loss function landscape introduces an additional source of variability that is confounded with sampling variability. In other words, some portion of the variability in the loss function across different resamples is due to local minima. Given that statistically sound model selection is based on an examination of variance, it is important to disentangle these two sources of variability. To that end, a methodology is developed for estimating each, specifically in the context of K-fold cross validation, and neural networks (NN) whose training leads to different local minima. Random effects models are used to estimate the two variance components—that due to sampling and that due to local minima. The results are examined as a function of the number of hidden nodes, and the variance of the initial weights, with the latter controlling the “depth” of local minima. The main goal of the methodology is to increase statistical power in model selection and/or model comparison. Using both simulated and realistic data, it is shown that the two sources of variability can be comparable, casting doubt on model selection methods that ignore the variability due to local minima. Furthermore, the methodology is sufficiently flexible so as to allow assessment of the effect of other/any NN parameters on variability.
Downscaling of Historical Wind Fields over Switzerland Using Generative Adversarial Networks
Authors: Miralles Ophélia , Steinfeld Daniel , Martius Olivia , Davison Anthony C. 
Published: October 2022

Abstract
Near-surface wind is difficult to estimate using global numerical weather and climate models, because airflow is strongly modified by underlying topography, especially that of a country such as Switzerland. In this article, we use a statistical approach based on deep learning and a high-resolution digital elevation model to spatially downscale hourly near-surface wind fields at coarse resolution from ERA5 reanalysis from their original 25-km grid to a 1.1-km grid. A 1.1-km-resolution wind dataset for 2016–20 from the operational numerical weather prediction model COSMO-1 of the national weather service MeteoSwiss is used to train and validate our model, a generative adversarial network (GAN) with gradient penalized Wasserstein loss aided by transfer learning. The results are realistic-looking high-resolution historical maps of gridded hourly wind fields over Switzerland and very good and robust predictions of the aggregated wind speed distribution. Regionally averaged image-specific metrics show a clear improvement in prediction relative to ERA5, with skill measures generally better for locations over the flatter Swiss Plateau than for Alpine regions. The downscaled wind fields demonstrate higher-resolution, physically plausible orographic effects, such as ridge acceleration and sheltering, that are not resolved in the original ERA5 fields.

Significance Statement
Statistical downscaling, which increases the resolution of atmospheric fields, is widely used to refine the outputs of global reanalysis and climate models, most commonly for temperature and precipitation. Near-surface winds are strongly modified by the underlying topography, generating local flow conditions that can be very difficult to estimate. This study develops a deep learning model that uses local topographic information to spatially downscale hourly near-surface winds from their original 25-km resolution to a 1.1-km grid over Switzerland. Our model produces realistic high-resolution gridded wind fields with expected orographic effects but performs better in flatter regions than in mountains. These downscaled fields are useful for impact assessment and decision-making in regions where global reanalysis data at coarse resolution may be the only products available.