bluuebunny/crossref_metadata_2025_split huggingface dataset:
Chemical and Mechanical Signals Trigger Courtship in the Wild Large-Headed Resin Bee Heriades truncorum
Authors: Ganuza Cristina , Ayasse Manfred , Boff Samuel 
Published: December 2022

AbstractHymenopteran females are mostly highly selective, choosing their mating partner according to male quality signals, and may also signal their fertility through chemical advertisement. Male insects, in turn, often display a complex set of courtship behaviors to allure females to mate. In this study we explored the mechanisms triggering courtship behaviors in the oligolectic bee Heriades truncorum. In this species, males perform wing fanning followed by a sideways rocking motion before copulation. We tested the role of chemical cues in partner recognition by exposing males to dead females washed from cuticular extracts (i.e., sex pheromones) that were posteriorly coated, or not, with an extract of unmated females. Additionally, we experimentally reduced male wing length to test whether wing fanning was responsible for triggering sideways rocking motions. We found males to interact more often with females coated by extracts from unmated females, and to display wing fanning in the presence of these pheromones. Male wing fanning was important to perform sideways rocking motions, which are an essential behavior for successful mating and possibly an element used by females to evaluate male quality. Our study shows that both chemical and mechanical signals from female and male bees, respectively, are important elements in the mating system of H. truncorum.
The MUSCAT Readout Electronics Backend: Design and Pre-deployment Performance
Authors: Rowe S. , Tapia M. , Barry P. S. , Karkare K. S. , Papageorgiou A. , Ade P. A. R. , Brien T. L. R. , Castillo-Domínguez E. , Ferrusca D. , Gómez-Rivera V. , Hargrave P. , Hernández-Rebollar J. L. , Hornsby A. , Jáuregui-García J. M. , Mauskopf P. , Murias D. , Pascale E. , Pérez A. , Smith M. W. L. , Tucker C. , Velázquez M. , Ventura S. , Hughes D. H. , Doyle S. 
Published: December 2022

AbstractMUSCAT is a new large-format 1.1 mm continuum camera for local and extra-galactic astronomy currently being installed at the 50 m Large Millimetre Telescope Alfonso Serrano, LMT. The focal plane is populated with 1458 feedhorn coupled Aluminium LEKIDs, cooled to 130 mk, and read out with 6 frequency division multiplexed RF readout chains, each with a 500 MHz bandwidth. The nominal mux ratio is $$\sim$$
∼
250 resonators per chain with an average spacing of 2 MHz between resonators. In each RF chain, the multiplexed waveform generation/decomposition is performed with the BLAST-TNG firmware on a ROACH2 FPGA board with a MUSIC DAC/ADC. The quadrature modulated IF signals are mixed to and from the LEKID readout band on a custom card that houses IQ mixers, a programmable synthesizer, and additional programmable input and output gain control and filtering. Within the cryostat, the RF signals are attenuated prior to reaching the focal plane array and then amplified at 4K. A novel software system controls all the programmable hardware and handles instructions from the LMT instrument control system to record and store observation data, as well as performing automated resonator retuning and providing results of quick look analysis to the telescope operators. In this paper, we present the detailed design and in-lab performance of the cryogenic and room temperature electronics, and the software control system.
Convergence Rates for the Relaxed Peaceman-Rachford Splitting Method on a Monotone Inclusion Problem
Authors: Sim Chee-Khian 
Published: December 2022

AbstractWe consider the convergence behavior using the relaxed Peaceman–Rachford splitting method to solve the monotone inclusion problem $$0 \in (A + B)(u)$$

0
∈
(
A
+
B
)
(
u
)

, where $$A, B: \Re ^n \rightrightarrows \Re ^n$$

A
,
B
:

ℜ
n

⇉

ℜ
n

are maximal $$\beta $$
β
-strongly monotone operators, $$n \ge 1$$

n
≥
1

and $$\beta > 0$$

β
>
0

. Under a technical assumption, convergence of iterates using the method on the problem is proved when either A or B is single-valued, and the fixed relaxation parameter $$\theta $$
θ
lies in the interval $$(2 + \beta , 2 + \beta + \min \{ \beta , 1/\beta \})$$

(
2
+
β
,
2
+
β
+
min
{
β
,
1
/
β
}
)

. With this convergence result, we address an open problem that is not settled in Monteiro et al. (Computat Optim Appl 70:763–790, 2018) on the convergence of these iterates for $$\theta \in (2 + \beta , 2 + \beta + \min \{ \beta , 1/\beta \})$$

θ
∈
(
2
+
β
,
2
+
β
+
min
{
β
,
1
/
β
}
)

. Pointwise convergence rate results and R-linear convergence rate results when $$\theta $$
θ
lies in the interval $$[2 + \beta , 2 + \beta + \min \{\beta , 1/\beta \})$$

[
2
+
β
,
2
+
β
+
min
{
β
,
1
/
β
}
)

are also provided in the paper. Our analysis to achieve these results is atypical and hence novel. Numerical experiments on the weighted Lasso minimization problem are conducted to test the validity of the assumption.
Analytic contact solutions of the Boussinesq and Cattaneo problems for an ellipsoidal power-law indenter
Authors: Willert Emanuel 
Published: December 2022

AbstractBased on Galin’s theorem for the indentation of an elastic half-space by a polynomial punch and Barber’s theorem for the determination of the contact area in elastic normal contact problems, an exact contact solution is developed for the frictionless indentation of an elastic half-space by an ellipsoidal power-law punch. Within the Cattaneo–Mindlin-approximation of tangential contacts, the tangential contact problem with friction can be reduced to the frictionless normal contact via the Ciavarella–Jäger principle, based on which also the tangential contact solution for the ellipsoidal power-law indenter is given. All known solutions for special cases (axisymmetric contact, elliptical Hertzian contact) are exactly recovered. A comparison of the pressure distribution obtained analytically for the 4-th power ellipsoidal indenter with a corresponding numerical solution based on the boundary element method shows no noticeable differences. The proposed solution procedure can also be used exactly for an arbitrary finite superposition of ellipsoidal power-law profiles, and, in an approximate sense, is applicable for arbitrary monotonous ellipsoidal profiles.
MicroRNA-588 regulates the invasive, migratory and vasculogenic mimicry-forming abilities of hypoxic glioma cells by targeting ROBO1
Authors: Yu Rui , Zhao Rongrong , Sun Xiaopeng , Zhang Zongpu , Wang Shaobo , Gao Xiao , Sun Zhongzheng , Xue Hao , Li Gang 
Published: December 2022

Abstract
Background
The microenvironment of hypoxia is an important factor contributing to the development of glioblastoma (GBM). MicroRNA-588 and its potential target Roundabout-directed receptor 1 (ROBO1) have been reported to promote tumor invasion and proliferation in diseases such as gastric, pancreatic and hepatocellular carcinoma, while their function in GBM and response to hypoxic states remain elusive.

Methods
A microarray was leveraged to identify differentially expressed microRNAs in U251 glioma cells cultured under normoxic and hypoxic conditions. The expression of miR-588 was assessed using quantitative real-time PCR (qRT‒PCR). Gain- and loss-of-function studies were used to evaluate the role of miR-588 under hypoxic and normoxic conditions. Cell invasion, migration, proliferation, and vasculogenic mimicry (VM) formation experiments were performed. The relationship between miR-588 and ROBO1 was confirmed using western blot and luciferase reporter assays. Intracranial xenograft tumor mouse models were used to study the function of miR-588 in vivo.

Results
The expression of miR-588 was significantly upregulated in hypoxic glioma cells relative to normoxic glioma cells. miR-588 inhibited the invasive, migratory and VM-forming abilities of glioma cells in vitro and in vivo. Mechanistically, roundabout guidance receptor 1 (ROBO1) is a direct, functionally relevant target of miR-588 in glioma. ROBO1 knockdown suppressed the expression of matrix metallopeptidase 2 (MMP2) and matrix metallopeptidase 9 (MMP9), thereby inhibiting the invasive, migratory and VM-forming abilities of glioma.

Conclusions
MiR-588 regulated the behaviors of hypoxic glioma cells by targeting ROBO1. miR-588 can be used as a prognostic marker for glioma and has potential implications in glioma gene therapy.
Un soneto olvidado de Calderón de la Barca para el Equilibrio cristiano político y moral de Gaspar Agustín de Lara (1680)
Authors: Gómez Canseco Luis , Navarro Antolín Fernando 
Published: December 2022

AbstractIn 1680 Pedro Calderón de la Barca wrote a sonnet for Gaspar Agustín de Lara’s Equilibrio cristiano político y moral. This paper edits the sonnet, completely unknown in Calderonian studies, and also analyzes the figure and the work of Lara.
Impact of land cover, rainfall and topography on flood risk in West Java
Authors: Rahayu Rahmawati , Mathias Simon A. , Reaney Sim , Vesuviano Gianni , Suwarman Rusmawan , Ramdhan Agus M. 
Published: December 2022

AbstractFlooding represents around 32% of total disasters in Indonesia and disproportionately affects the poorest of communities. The objective of this study was to determine significant statistical differences, in terms of river catchment characteristics, between regions in West Java that reported suffering from flood disasters and those that did not. Catchment characteristics considered included various statistical measures of topography, land-use, soil-type, meteorology and river flow rates. West Java comprises 154 level 9 HydroSHEDS sub-basin regions. We split these regions into those where flood disasters were reported and those where they were not, for the period of 2009 to 2013. Rainfall statistics were derived using the CHIRPS gridded precipitation data package. Statistical estimates of river flow rates, applicable to ungauged catchments, were derived from regionalisation relationships obtained by stepwise linear regression with river flow data from 70 West Javanese gauging stations. We used Kolmogorov–Smirnov tests to identify catchment characteristics that exhibit significant statistical differences between the two sets of regions. Median annual maximum river flow rate (AMRFR) was found to be positively correlated with plantation cover. Reducing plantation land cover from 20 to 10% was found to lead to a modelled 38% reduction in median AMRFR. AMRFR with return periods greater than 10 years were found to be negatively correlated with wetland farming land cover, suggesting that rice paddies play an important role in attenuating extreme river flow events. Nevertheless, the Kolmogorov–Smirnov tests revealed that built land cover is the most important factor defining whether or not an area is likely to report flood disasters in West Java. This is presumably because the more built land cover, the more people available to experience and report flood disasters. Our findings also suggest that more research is needed to understand the important role of plantation cover in aggravating median annual maximum river flow rates and wetland farming cover in mitigating extreme river flow events.
Prediction scoring of data-driven discoveries for reproducible research
Authors: Smith Anna L. , Zheng Tian , Gelman Andrew 
Published: December 2022

AbstractPredictive modeling uncovers knowledge and insights regarding a hypothesized data generating mechanism (DGM). Results from different studies on a complex DGM, derived from different data sets, and using complicated models and algorithms, are hard to quantitatively compare due to random noise and statistical uncertainty in model results. This has been one of the main contributors to the replication crisis in the behavioral sciences. The contribution of this paper is to apply prediction scoring to the problem of comparing two studies, such as can arise when evaluating replications or competing evidence. We examine the role of predictive models in quantitatively assessing agreement between two datasets that are assumed to come from two distinct DGMs. We formalize a distance between the DGMs that is estimated using cross validation. We argue that the resulting prediction scores depend on the predictive models created by cross validation. In this sense, the prediction scores measure the distance between DGMs, along the dimension of the particular predictive model. Using human behavior data from experimental economics, we demonstrate that prediction scores can be used to evaluate preregistered hypotheses and provide insights comparing data from different populations and settings. We examine the asymptotic behavior of the prediction scores using simulated experimental data and demonstrate that leveraging competing predictive models can reveal important differences between underlying DGMs. Our proposed cross-validated prediction scores are capable of quantifying differences between unobserved data generating mechanisms and allow for the validation and assessment of results from complex models.
Chronic Mild Traumatic Brain Injury: Aberrant Static and Dynamic Connectomic Features Identified Through Machine Learning Model Fusion
Authors: Simos Nicholas J. , Manolitsi Katina , Luppi Andrea I. , Kagialis Antonios , Antonakakis Marios , Zervakis Michalis , Antypa Despina , Kavroulakis Eleftherios , Maris Thomas G. , Vakis Antonios , Stamatakis Emmanuel A. , Papadaki Efrosini 
Published: December 2022

AbstractTraumatic Brain Injury (TBI) is a frequently occurring condition and approximately 90% of TBI cases are classified as mild (mTBI). However, conventional MRI has limited diagnostic and prognostic value, thus warranting the utilization of additional imaging modalities and analysis procedures. The functional connectomic approach using resting-state functional MRI (rs-fMRI) has shown great potential and promising diagnostic capabilities across multiple clinical scenarios, including mTBI. Additionally, there is increasing recognition of a fundamental role of brain dynamics in healthy and pathological cognition. Here, we undertake an in-depth investigation of mTBI-related connectomic disturbances and their emotional and cognitive correlates. We leveraged machine learning and graph theory to combine static and dynamic functional connectivity (FC) with regional entropy values, achieving classification accuracy up to 75% (77, 74 and 76% precision, sensitivity and specificity, respectively). As compared to healthy controls, the mTBI group displayed hypoconnectivity in the temporal poles, which correlated positively with semantic (r = 0.43, p < 0.008) and phonemic verbal fluency (r = 0.46, p < 0.004), while hypoconnectivity in the right dorsal posterior cingulate correlated positively with depression symptom severity (r = 0.54, p < 0.0006). These results highlight the importance of residual FC in these regions for preserved cognitive and emotional function in mTBI. Conversely, hyperconnectivity was observed in the right precentral and supramarginal gyri, which correlated negatively with semantic verbal fluency (r=-0.47, p < 0.003), indicating a potential ineffective compensatory mechanism. These novel results are promising toward understanding the pathophysiology of mTBI and explaining some of its most lingering emotional and cognitive symptoms.
Engraftment syndrome following Hematopoietic stem cell transplantation: a systematic approach toward diagnosis and management
Authors: Maqbool Shahzaib , Nadeem Muhammad , Shahroz Ahmad , Naimat Kiran , Khan Imran , Tahir Hassaan , Rehman Abdur , Anwer Faiz , Iftikhar Raheel , Lee Ka Yiu 
Published: December 2022

AbstractEngraftment syndrome (ES) is a non-infectious complication seen both in autologous and allogeneic hematopoietic stem cell transplants and is characterized by the presence of non-infectious fever, diarrhea, skin rash, pulmonary infiltration, pulmonary edema, and deranged renal and liver function tests This review will be delineating the incidence of ES, important differential diagnoses to be considered and management options. The literature search was done through various databases like PubMed, Google scholar, Cochrane library, and EMBASE. The incidence of engraftment syndrome was ranging from 8 to 50% in patients undergoing Autologous stem cell transplantation while the incidence was 10–77% in patients undergoing Allogeneic stem cell transplantation. Fever was the most commonly observed symptom of ES in both Autologous and Allogeneic stem cell transplantation while the second most frequently reported symptom was non-infectious diarrhea in patients undergoing autologous stem cell transplantation and Skin rash in patients with Allogeneic stem cell transplantation. Pro-inflammatory cytokines and immune response dysregulation were highlighted as the mechanism behind ES development. The significant difference between ES and aGVHD was observed based on cytokines, with IL-12, IL-1β, IL-6, TNF-α, and IFN-γ levels in plasma being higher in patients with ES as compared to patients with aGVHD. Intravenous methylprednisolone was used as the treatment of choice in the majority of the studies. Overall the incidence of ES was high in patients undergoing allogeneic hematopoietic stem cells transplantation. The survival in patients developing ES was less compared to those who did not develop ES. Engraftment syndrome is one of the complications following hematopoietic stem cell transplantation that need early identification, differentiation from infectious complications, and aGVHD and timely initiation of corticosteroids therapy.
Glutamine induces remodeling of tight junctions in Caco-2 colorectal cancer cell
Authors: Huang Ching-Ying , Chen Ji-Kai , Kuo Wei-Ting 
Published: December 2022

AbstractMalignant cells often exhibit significant metabolic alterations, including the utilization of different nutrients to meet energetic and biosynthetic demands. Recent studies have shown that glutamine can support primary colorectal tumor growth and also serve as an alternate energy source during distant metastasis under glucose-limited conditions. However, the overall effects of glutamine on cancer cell physiology are not completely understood. In this study, we investigated how glutamine impacts epithelial integrity in colorectal cancer cells under glucose deprivation. Human colorectal cancer (Caco-2) cells were grown to confluency in transwells and cultured in glucose/pyruvate-free DMEM with various glutamine concentrations (0–50 mM). Cell viability was assessed, and monolayer integrity was examined in terms of transepithelial resistance (TER) and paracellular permeability. Tight junction (TJ) component proteins were examined by immunofluorescence staining and Western blotting. A dose-dependent decrease in TER was observed in Caco-2 cells, but paracellular permeability was not affected after 24 h incubation with glutamine. At the same time, the TJ proteins, zonula occludens (ZO)-1 and Claudin-1, showed lateral undulations and punctate staining patterns accompanied by enlargement of cellular and nuclear sizes. Furthermore, decreased protein levels of ZO-1, but not claudin-1, were found in detergent-insoluble cellular fractions. Notably, the decreased TER and alterations in TJ structure were not associated with cell viability changes. Moreover, the addition of glutamate, which is produced by the first step of glutamine catabolism, had no impact on TER. Our results suggested that the enteral glutamine may play an important role in the regulation of TJ dynamics in colorectal cancer cells.
The Reach and Impact of Birthright Israel: What We Can Learn from Pew’s “Jewish Americans in 2020”
Authors: Saxe Leonard , Wright Graham , Hecht Shahar 
Published: December 2022

AbstractThe Pew Research Center’s 2020 survey of American Jews is a valuable resource to scholars of American Jewry, enabling interrogation of questions using data that no other source can reliably provide. One set of questions pertains to the reach and impact of Birthright Israel, the largest extant Jewish educational program targeted at Jewish young adults, on American Jews. Pew’s nationally representative sample provides important validation of previous findings regarding Birthright’s impact on participants and extends the generalizability of what has been learned. In this paper we use data from the 2020 Pew survey to assess the program’s “reach” into different segments of the American Jewish population and to extend the validity of existing findings regarding the program’s impact on participants’ attitudes and behaviors related to Israel and Jewish life. Pew’s data estimate that around 20% of American Jews ages 18–46 have participated in Birthright, and that among Jewish parents with a grown child, nearly 30% have an adult child who participated in the program. After controlling for preexisting differences between participants and those who have never been to Israel, Pew’s data also confirm that Birthright has a significant impact on a broad set of Jewish outcomes. These results support a more optimistic view of the future for US Jewry and suggest that the investment in large-scale educational interventions can substantially alter the trajectory of the American Jewish community writ large.
Sub-Seasonal Experiment (SubX) Model-based Assessment of the Prediction Skill of Recent Multi-Year South Korea Droughts
Authors: Park Chang-Kyun , Kam Jonghun 
Published: December 2022

Abstract
Reliable sub-seasonal forecast of precipitation is essential to manage the risk of multi-year droughts in a timely manner. However, comprehensive assessments of sub-seasonal prediction skill of precipitation remain limited, particularly during multi-year droughts. This study used various verification metrics to assess the sub-seasonal prediction skill of hindcasts of five Sub-seasonal Experiment (SubX) models for precipitation during two recent multi-year South Korea droughts (2007 − 10 and 2013 − 16). Results show that the sub-seasonal prediction skill of the SubX models were stage-, event-, and model-dependent over the recent multi-year droughts. According to the Brier skill scores, SubX models show a more skillful in one to four lead weeks during the drought onset and persistence stages, than the recovery stage. While the prediction skill of the SubX models in the first two initial weeks show more skillful prediction during the 2007–10 drought, the impact of the forecast initial time on the prediction skill is relatively weak during the 2013–16 drought. Overall, the EMC-GEFSv12 model with the 11 ensemble members (the largest among the five SubX models) show the most skillful forecasting skill. According to the sensitivity test to the ensemble member size, the EMC-GEFSv12 model had no gain for biweekly precipitation forecast with the nine ensemble members or more. This study highlights the importance of a robust evaluation of the predictive performance of sub-seasonal climate forecasts via multiple verification metrics.