bluuebunny/crossref_metadata_2025_split huggingface dataset:
Relating individual motion sickness levels to subjective discomfort ratings
Authors: de Winkel Ksander N. , Irmak Tuğrul , Kotian Varun , Pool Daan M. , Happee Riender 
Published: February 2022

AbstractHigh levels of vehicle automation are expected to increase the risk of motion sickness, which is a major detriment to driving comfort. The exact relation between motion sickness and discomfort is a matter of debate, with recent studies suggesting a relief of discomfort at the onset of nausea. In this study, we investigate whether discomfort increases monotonously with motion sickness and how the relation can best be characterized in a semantic experiment (Experiment 1) and a motion sickness experiment (Experiment 2). In Experiment 1, 15 participants performed pairwise comparisons on the subjective discomfort associated with each item on the popular MIsery SCale (MISC) of motion sickness. In Experiment 2, 17 participants rated motion sickness using the MISC during exposures to four sustained motion stimuli, and provided (1) numerical magnitude estimates of the discomfort experienced for each level of the MISC, and (2) verbal magnitude estimates with seven qualifiers, ranging between feeling ‘excellent’ and ‘terrible’. The data of Experiment 1 show that the items of the MISC are ranked in order of appearance, with the exception of 5 (‘severe dizziness, warmth, headache, stomach awareness, and sweating’) and 6 (‘slight nausea’), which are ranked in opposite order. However, in Experiment 2, we find that discomfort associated with each level of the MISC, as it was used to express motion sickness during exposure to a sickening stimulus, increases monotonously; following a power law with an exponent of 1.206. While the results of Experiment 1 replicate the non-linearity found in recent studies, the results of Experiment 2 suggest that the non-linearity is due to the semantic nature of Experiment 1, and that there is a positive monotonous relation between MISC and discomfort in practice. These results support the suitability of MISC to assess motion sickness.
Case report of unusual insertion of the fibularis brevis muscle
Authors: Ruzik Kacper , Westrych Karolina , Konschake Marko , Tubbs R. Shane , Karauda Piotr , Olewnik Łukasz 
Published: February 2022

AbstractThe fibularis brevis and fibularis longus muscles belong to the lateral compartment of the leg. The fibularis brevis is morphologically variable, especially in the number of tendons and place of insertion. Its type of insertion is correlated with the presence of a fibularis digiti quinti, which is also anatomically variable. We present a case study based on dissection of a seventy-three-year-old female cadaver with an unusual insertion of the fibularis brevis muscle. The tendon had three bands inserting into the fifth metatarsal bone. There was a coexisting fibularis digiti quinti, which was fused with the fibularis tertius muscle. Awareness of such anatomical variation could be useful during reconstructive surgery and planning rehabilitation protocols.
Nutrient fluxes from an Arctic seabird colony to the adjacent coastal marine ecosystem
Authors: Finne Eirik A. , Varpe Øystein , Durant Joël M. , Gabrielsen Geir W. , Poste Amanda E. 
Published: February 2022

AbstractSeabirds are important vectors for nutrient transfer across ecosystem boundaries. In this seasonal study, we evaluate the impact of an Arctic colony (Alkhornet, Svalbard) of Black-legged Kittiwakes (Rissa tridactyla) and Brünnich’s Guillemots (Uria lomvia) on stream nutrient concentrations and fluxes, as well as utilization by coastal biota. Water samples from seabird-impacted and control streams were collected regularly throughout the melt season (June–September) for nutrient and organic carbon analysis. Stable carbon and nitrogen isotope analysis (δ13C and δ15N) was used to assess whether seabird-derived nitrogen (N) could be traced into filamentous stream algae and marine algae as well as consumers (amphipods). Concentrations of nitrate (NO3−) and nitrite (NO2−) peaked in July at 9200 µg N L−1 in seabird-impacted streams, 70 times higher than for control streams. Mean concentrations of phosphate (PO43−) in seabird-impacted streams were 21.9 µg P L−1, tenfold higher than in controls. Areal fluxes from seabird-impacted study catchments of NO3− + NO2− and PO43− had estimated ranges of 400–2100 kg N km−2 and 15–70 kg P km−2, respectively. Higher δ15N was found in all biota collected from seabird-impacted sites, indicating utilization of seabird-derived nitrogen. Acrosiphonia sp. from seabird-impacted sites had higher δ15N values (20–23‰ vs. 3–6‰) and lower C:N ratios (10.9 vs. 14.3) than specimens collected from control sites, indicating reliance on seabird-derived nitrogen sources and potentially higher N-availability at seabird-impacted nearshore sites. Our study demonstrates how marine nutrients brought onshore by seabirds also can return to the ocean and be utilized by nearshore primary producers and consumers.
Social identity and risky leisure activities: implications for welfare and policy
Authors: Mannberg Andrea , Sjögren Tomas 
Published: February 2022

AbstractIn this paper, we build on theories in psychology and economics and link positional preferences to private agents’ identification with a social group, and the social norms present in that group. The purpose of our paper is to analyze behavioral, welfare, and policy implications of a link between private agents´ social identity and a risky leisure activity. Our results suggest that, when the outcome of the positional activity is uncertain, the over-consumption result that is associated with positional preferences in a deterministic framework need not apply to all agents in a social equilibrium. The reason is that agents have incentives to act with caution in order to avoid failure when the outcome of the socially valued activity is uncertain. We also show how policy can be used to improve the welfare within a social group where the risky leisure activity is positional.
Using visual feedback to improve hand movement accuracy in confined-occluded spaces in virtual reality
Authors: Wang Yu , Hu Ziran , Yao Shouwen , Liu Hui 
Published: February 2022

AbstractAccurate and informative hand-object collision feedback is of vital importance for hand manipulation in virtual reality (VR). However, to our best knowledge, the hand movement performance in fully-occluded and confined VR spaces under visual collision feedback is still under investigation. In this paper, we firstly studied the effects of several popular visual feedback of hand-object collision on hand movement performance. To test the effects, we conducted a within-subject user study (n=18) using a target-reaching task in a confined box. Results indicated that users had the best task performance with see-through visualization, and the most accurate movement with the hybrid of proximity-based gradation and deformation. By further analysis, we concluded that the integration of see-through visualization and proximity-based visual cue could be the best compromise between the speed and accuracy for hand movement in the enclosed VR space. On the basis, we designed a visual collision feedback based on projector decal,which incorporates the advantages of see-through and color gradation. In the end, we present demos of potential usage of the proposed visual cue.
Hydrological cycle of the Mediterranean-Black Sea system
Authors: García-García David , Vigo M. Isabel , Trottini Mario , Vargas-Alemañy Juan A. , Sayol Juan-Manuel 
Published: February 2022

AbstractThe Mediterranean-Black Sea system consists of two semi-enclosed basins connected by the Turkish Straits. In turn, the Mediterranean Sea is connected to the Atlantic Ocean through the narrow Strait of Gibraltar. The hydrological cycle of the system is driven by fresh water exchanges between the atmosphere, continents and oceans, and by salty water mass exchange among the ocean basins. Monitoring such water fluxes, especially its time evolution, is essential to understand the water cycle in the region, which is very sensitive to global climate changes and influences the variability of the Atlantic Meridional Overturning Circulation (AMOC), which in turn affects the global climate. In this study, we have estimated the hydrological cycle of the Mediterranean-Black Sea system from the time-variable gravity observations performed by the Gravity Recovery and Climate Experiment (GRACE) and GRACE Follow-On satellites, and precipitation and evaporation from ERA5 atmospheric reanalysis data for the period 2002–2020. In the Black Sea, rivers introduce an average water volume of 391 ± 12 km3/year, one third of which escape through the atmosphere and two thirds go to the Mediterranean Sea. In the latter, 1787 ± 23 km3/year are lost via net evaporation. The rivers runoff (502 ± 27 km3/year), and the inflow of Atlantic waters (1020 ± 56 km3/year; 0.0323 ± 0.0018 Sv), finally restore the Mediterranean water budget. The balance is not reached instantaneously, and this delay introduces a seasonal variability in all the fluxes. In particular, the net water flux from the Atlantic Ocean increases up to 2660 ± 111 km3/year in August/September, and reverses to − 407 ± 140 km3/year in April/May. On top of the climatology, the mean annual Atlantic water flux varies significantly between 706 and 1262 km3/year.
Machine learning applied to ambulatory blood pressure monitoring: a new tool to diagnose autonomic failure?
Authors: Vallelonga Fabrizio , Sobrero G. , Merola A. , Valente M. , Giudici M. , Di Stefano C. , Milazzo V. , Burrello J. , Burrello A. , Veglio F. , Romagnolo A. , Maule S. 
Published: February 2022

Abstract
Background
Autonomic failure (AF) complicates Parkinson’s disease (PD) in one-third of cases, resulting in complex blood pressure (BP) abnormalities. While autonomic testing represents the diagnostic gold standard for AF, accessibility to this examination remains limited to a few tertiary referral centers.

Objective
The present study sought to investigate the accuracy of a machine learning algorithm applied to 24-h ambulatory BP monitoring (ABPM) as a tool to facilitate the diagnosis of AF in patients with PD.

Methods
Consecutive PD patients naïve to vasoactive medications underwent 24 h-ABPM and autonomic testing. The diagnostic accuracy of a Linear Discriminant Analysis (LDA) model exploiting ABPM parameters was compared to autonomic testing (as per a modified version of the Composite Autonomic Symptom Score not including the sudomotor score) in the diagnosis of AF.

Results
The study population consisted of n = 80 PD patients (33% female) with a mean age of 64 ± 10 years old and disease duration of 6.2 ± 4 years. The prevalence of AF at the autonomic testing was 36%. The LDA model showed 91.3% accuracy (98.0% specificity, 79.3% sensitivity) in predicting AF, significantly higher than any of the ABPM variables considered individually (hypotensive episodes = 82%; reverse dipping = 79%; awakening hypotension = 74%).

Conclusion
LDA model based on 24-h ABPM parameters can effectively predict AF, allowing greater accessibility to an accurate and easy to administer test for AF. Potential applications range from systematic AF screening to monitoring and treating blood pressure dysregulation caused by PD and other neurodegenerative disorders.
Comparison of peripheral refraction and higher-order aberrations between orthokeratology and multifocal soft contact lens designed with highly addition
Authors: Huang Yingying , Li Xue , Ding Chenglu , Chen Yunyun , Mao Xinjie , Chen Hao , Bao Jinhua 
Published: February 2022

Abstract
Purpose
To compare peripheral defocus, higher-order aberrations (HOAs), and contrast visual acuity (CVA) in myopic children wearing orthokeratology (OK) lenses and multifocal soft contact lenses (MSCLs) designed with highly addition.

Methods
This is a prospective, nonrandomized, controlled study. Subjects at 8 to 13 years of age with spherical equivalent refraction from − 1.00 to − 5.00 dioptres (D) were included in the OK group (n = 30) and MSCL group (n = 23). Relative peripheral corneal defocus (RPCD) and relative peripheral refraction (RPR) were measured before and after wearing lenses. HOAs including spherical aberration (SA), coma, trefoil, and total HOAs, and high (100%) and low (10%) CVA were compared between the groups. Axial length (AL) was measured before and after wearing the lenses for 1 year.

Results
After wearing the lenses, subjects in the MSCL group had RPCD and RPR values similar to the OK group at the paracentral (within 2 mm of the cornea or 20° of the retina, all p > 0.05) but larger than the OK group at the periphery (all p < 0.05). All HOAs increased after wearing the lenses except the trefoil in the MSCL group (all p < 0.05). HOAs increased more in the OK group (all p < 0.05). The 100% and 10% CVAs were worse in the MSCL group (p = 0.02 and p = 0.004). After 1 year, AL elongation was 0.37 mm (SD = 0.16) in the MSCL group and 0.28 mm (0.16) in the OK group (p = 0.06).

Conclusion
MSCL produced larger myopic defocus at the periphery, increased less HOAs and had worse CVA than OK lens. The high addition of this MSCL did not result in better myopia control efficacy

Trial registration
Chinese Clinical Trial Registry: ChiCTR1800018564. Registered 25 September 2018; retrospectively registered, http://www.chictr.org.cn/showproj.aspx?proj=31376
Early elective versus elective sigmoid resection in diverticular disease: not only timing matters—a single institutional retrospective review of 133 patients
Authors: Vaghiri Sascha , Jagalla David Mario , Prassas Dimitrios , Knoefel Wolfram Trudo , Krieg Andreas 
Published: February 2022

Abstract
Purpose
The optimal timing of elective surgery in patients with the colonic diverticular disease remains controversial. We aimed to analyze the timing of sigmoidectomy in patients with diverticular disease and its influence on postoperative course with respect to the classification of diverticular disease (CDD).

Methods
Patients who underwent elective laparoscopic sigmoidectomy were retrospectively enrolled and subdivided into two groups based on the time interval between the last attack and surgery: group A, early elective (≤ 6 weeks), and group B, elective (> 6 weeks). Multivariate regression models were used to identify factors which predict conversion to laparotomy, postoperative course, and length of hospital stay.

Results
A total of 133 patients (group A (n = 88), group B (n = 45)) were included. Basic demographic data did not differ between groups except for a higher rate of diabetes in group B (p = 0.009). The conversion rate was significantly higher in group A in comparison to group B (group A vs. group B: n = 23 (26.1%) vs. n = 3 (6.7%), p = 0.007). Logistic regression analysis revealed the timing of surgery and CDD stage as significant predictors for intraoperative conversion. Moreover, the postoperative course was influenced by high age as well as intraoperative conversion and length of hospital stay by conversion, preoperative CRP levels, and elective surgery.

Conclusions
Both, timing of surgery and the disease stage, influence the conversion rates in laparoscopic sigmoidectomy for diverticular disease. Accordingly, patients with complicated acute or chronic sigmoid diverticulitis should be operated in the inflammation-free interval.
Explicit vs. implicit spatial processing in arrow vs. eye-gaze spatial congruency effects
Authors: Narganes-Pineda Cristina , Chica Ana B. , Lupiáñez Juan , Marotta Andrea 
Published: February 2022

AbstractArrows and gaze stimuli lead to opposite spatial congruency effects. While standard congruency effects are observed for arrows (faster responses for congruent conditions), responses are faster when eye-gaze stimuli are presented on the opposite side of the gazed-at location (incongruent trials), leading to a reversed congruency effect (RCE). Here, we explored the effects of implicit vs. explicit processing of arrows and eye-gaze direction. Participants were required to identify the direction (explicit task) or the colour (implicit task) of left or right looking/pointing gaze or arrows, presented to either the left or right of the fixation point. When participants responded to the direction of stimuli, standard congruency effects for arrows and RCE for eye-gaze stimuli were observed. However, when participants responded to the colour of stimuli, no congruency effects were observed. These results suggest that it is necessary to explicitly pay attention to the direction of eye-gaze and arrows for the congruency effect to occur. The same pattern of data was observed when participants responded either manually or verbally, demonstrating that manual motor components are not responsible for the results observed. These findings are not consistent with some hypotheses previously proposed to explain the RCE observed with eye-gaze stimuli and, therefore, call for an alternative plausible hypothesis.
PECARN Rule in diagnostic process of pediatric patients with minor head trauma in emergency department
Authors: Gambacorta Alessandro , Moro Marianna , Curatola Antonietta , Brancato Federica , Covino Marcello , Chiaretti Antonio , Gatto Antonio 
Published: February 2022

AbstractThis study aims to evaluate the efficacy of the PECARN Rule (PR) in reducing radiological investigations in children with mild traumatic head injury in comparison with current clinical practice. A retrospective study was performed in our hospital between July 2015 and June 2020. Data of all children < 18 years of age admitted to the emergency department (ED), within 24 h after a head trauma with GCS ≥ 14, were analyzed. PECARN Rule was retrospectively applied to all patients. In total, 3832 patients were enrolled, 2613 patients ≥ 2 years and 1219 < 2 years. In the group of children ≥ 2 years, 10 presented clinically important traumatic brain injury (ciTBI) and were hospitalized, 7/10 underwent neurosurgery, and 3/10 clinical observation in the pediatric ward for more than 48 h. In children < 2 years, only 3 patients presented ciTBI, 2 underwent neurosurgery and 1 hospitalized. Applying the PR, no patient with ciTBI would have been discharged without an accurate diagnosis and we would have avoided 139 CT scans in patients ≥ 2 years, and 23 in those < 2 years of age (29% less).Conclusion: We demonstrated the safety and validity of the PR in our setting with 100% sensitivity in both age groups in identifying patients with ciTBI and theoretically in reducing performed CT scans by 29%. Therefore, in patients classified in the low-risk category, it is a duty not to expose the child to ionizing radiation.

What is Known:• CT is the gold standard to identify intracranial pathology in children with head injury but CT imaging of head-injured children expose them to higher carcinogenic risk.• PECARN Rules support doctors in identifying children with ciTBI in order to reduce exposure to ionizing radiation.

What is New:• We demonstrate the safety and validity of the PR with 100% sensitivity in both age groups in identifying patients with ciTBI.• In our setting, the application of PECARN Rule would theoretically have allowed us to reduce the CT scan by 29%.
TMB and BRAF mutation status are independent predictive factors in high-risk melanoma patients with adjuvant anti-PD-1 therapy
Authors: Eckardt Julia , Schroeder Christopher , Martus Peter , Armeanu-Ebinger Sorin , Kelemen Olga , Gschwind Axel , Bonzheim Irina , Eigentler Thomas , Amaral Teresa , Ossowski Stephan , Rieß Olaf , Flatz Lukas , Garbe Claus , Forschner Andrea 
Published: February 2022

Abstract
Background
High tumor mutational burden (TMB) is associated with a favorable outcome in metastatic melanoma patients treated with immune checkpoint inhibitors. However, data are limited in the adjuvant setting. As BRAF mutated patients have an alternative with targeted adjuvant therapy, it is important to identify predictive factors for relapse and recurrence-free survival (RFS) in patients receiving adjuvant anti-PD-1 antibodies.

Methods
We evaluated 165 melanoma patients who started adjuvant anti-PD-1 antibody therapy at our center between March 2018 and September 2019. The initial tumor stage was assessed at the beginning of therapy according to the 8th edition of the AJCC Cancer Staging Manual. Tumor and normal tissue of the high-risk stages IIIC/D/IV were sequenced using a 700 gene NGS panel.

Results
The tumor stages at the beginning of adjuvant anti-PD-1 therapy were as follows: N = 80 stage IIIA/B (48%), N = 85 stage IIIC/D/IV (52%). 72/165 patients (44%) suffered a relapse, 44/72 (61%) with only loco regional and 28/72 (39%) with distant metastases. Sequencing results were available from 83 to 85 patients with stage IIIC/D/IV. BRAF mutation status (HR 2.12, 95% CI 1.12–4.08; p = 0.022) and TMB (HR 7.11, 95% CI 2.19–23.11; p = 0.001) were significant and independent predictive factors for relapse-free survival (RFS).

Conclusion
BRAF mutation status and TMB were independent predictive factors for RFS. Patients with BRAF V600E/K mutation and TMB high had the best outcome. A classification based on BRAF mutation status and TMB is proposed to predict RFS in melanoma patients with adjuvant anti-PD-1 therapy.
Leaf-chewing herbivores affect preference and performance of a specialist root herbivore
Authors: Karssemeijer Peter N. , Winzen Laura , van Loon Joop J. A. , Dicke Marcel 
Published: February 2022

AbstractPlants interact with a diversity of phytophagous insects above- and belowground. By inducing plant defence, one insect herbivore species can antagonize or facilitate other herbivore species feeding on the same plant, even when they are separated in space and time. Through systemic plant-mediated interactions, leaf-chewing herbivores may affect the preference and performance of root-feeding herbivores. We studied how six different leaf-chewing herbivore species ofBrassica oleraceaplants affected oviposition preference and larval performance of the root-feeding specialistDelia radicum. We expected that femaleD. radicumflies would oviposit where larval performance was highest, in accordance with the preference–performance hypothesis. We also assessed how the different leaf-chewing herbivore species affected defence-related gene expression in leaves and primary roots ofB. oleracea, both before and after infestation with the root herbivore. Our results show that leaf-chewing herbivores can negatively affect the performance of root-feedingD. radicumlarvae, although the effects were relatively weak. Surprisingly, we found that adultD. radicumfemales show a strong preference to oviposit on plants infested with a leaf-chewing herbivore. Defence-related genes in primary roots ofB. oleraceaplants were affected by the leaf-chewing herbivores, but these changes were largely overridden upon local induction byD. radicum. Infestation by leaf herbivores makes plants more attractive for oviposition byD. radicumfemales, while decreasing larval performance. Therefore, our findings challenge the preference–performance hypothesis in situations where other herbivore species are present.