bluuebunny/crossref_metadata_2025_split huggingface dataset:
Social Grievances and Drugs Rummage-Sale as Performance Enhancement Attitude of Mature Athletes – An Inferential Approach
Authors: Javed Saeed , Shoukat Aisha , Naseer Abida , Jafar Muhammad , Safdar Nabeel , Sher Ali 
Published: January 2022

Objective: The central objective of the present study was to determine the relationship between social grievances and drugs rummage-sale (performance enhancement attitude) of the mature athletes of Pakistan and examine their difference as well.
Methodology: The targeted population was mature national athletes belonging to national sports departments. The respondents were recruited through snowball and convenient sampling methods. Total 105 questionnaires were posted at the given addresses of athletes. However, 73 athletes (69.5%) returned the questionnaires. For achieving study objectives, quantitative approach was adopted wherein several statistical tests were performed including descriptive statistics, Pearson’s correlation, and t-test analyses and implemented to draw the required study findings.
Results: The findings revealed that a strong association exists between social grievances and drugs rummage use. Therefore, the relationship was considered positive and highly significant among the constructs. On the other hand, the findings revealed no difference between social grievances and drugs rummage-use. The findings revealed that social grievance and drug rummage-sale positively contribute to enhance the sports performance of athletes.
Conclusion: It was concluded that athletes use drugs for several purposes such as enhancing performance, competing for highest sports level, gaining fame, and jobs opportunities. However, with these benefits, the athletes fell in diverse health complications as a side effect of drugs being taken for above said purposes.
Study on the Anti-cancer Potential of Aegle marmelos Fruit Extract Pro and Anti Apoptotic Molecule in Human Melanoma Cell Line-A375
Authors: Venkatakarthikeswari G. V. , Devi R. Gayatri , Selavaraj J. , Priya A. Jothi 
Published: January 2022

Aegle marmelos is also known as bael which is commonly found in south East Asia and Indian-sub continent. The origin of bael is India. Bael is also known as the golden apple, Bengal-quince in India. In the ancient medical system, Aegle marmelos play an important role and its extract is also useful in inflammation, diabetes, cancer and asthma. The leaves are used for anti-inflammatory, nervous disorder, control blood sugar and fruit is used to treat antiviral, anti-diabetics, and brain and heart tonic. In addition, studies have proved that bael is used for the treatment and prevention of cancer. The main aim of this study is to assess the anti-cancer potential of Aegle marmelos fruit extract pro and anti apoptotic molecules in human melanoma cell line-A375. In the present study, Human Melanoma A375 cells will be produced, grown and will be passed in different culture flasks, then RNA isolation was done and by reverse transcriptase process, RNA gets converted into cDNA. This cDNA will be used for the amplification of growth factor beta using gene specific primers by commercially available real time PCR kit. The anticancer potential effect was found in 400µg/ml, as the concentration increases, the cell viability is decreased. The current study explains the potential application of bael in pharmacological and medicinal uses in near future.
Resistance Exercise Reduces the Necessity for Hypoglycemic Agent (Humulin) in Overweight Women with Gestational Diabetes Mellitus
Authors: Selvi P. , Manivannan V. , Martina G. Liji , Senbagavalli V. , Thanuja C. Selvin , Rengarajan N. 
Published: January 2022

Background: Gestational Diabetes Mellitus (GDM) is currently treated with blood sugar monitoring, nutritional supplements, increased fatal police work, and hypoglycemic agent medical help PRN to achieve and maintain normoglycemia. Even though humulin therapy has been demonstrated to reduce low birth weight in women with GDM, using hypoglycemic drugs is likely challenging and may not address peripheral hypoglycemic agent resistance, which is a critical role in the development of GDM. Furthermore, the use of aggressive low blood sugar medication therapy may result in a twofold rise in the amount of small-for-gestational-age infants. The resistance exercise was used in overweight women with Gestational Diabetes Mellitus. Because resistance exercise increase the lean body muscle or decrease the body fat and Resistance exercise is an effective glycaemic management and cardio metabolic health strategy.
Methods: Fifteen patients with physiological condition DM were arbitrarily assigned whether it's to a group that received strength training or to a group that did not receive strength training to scale back the necessity for the hypoglycaemic agent.
Results: Despite therapy, the number of girls who required hypoglycemic agent medical care has been the same. However, a meta-analysis with only overweight girls (pre-pregnancy BMI) revealed that the exercise cluster used to have a lower rate of hypoglycemic medication use (P<05) than that of the non-exercise receiving patients.
Conclusion: Resistance exercise coaching might facilitate to avoid hypoglycaemic agent medical aid for pregnant overweight girls with physiological state diabetes
Antibacterial Activity of Padikara Parpam against ESBL Producing Escherichia coli and Klebsiella pneumoniae
Authors: Akilan Anitha , Anthony Josephine , Kasthuri Revathi 
Published: January 2022

Aims: To evaluate the antibacterial activity of Padikara Parpam against Extended-Spectrum Beta-Lactamase (ESBL) producing Escherichia Coli and Klebsiella Pneumoniae using agar well diffusion method. To identify ESBL producing bacteria by phenotypic confirmatory test using disk diffusion method.
Study Design: Analysis of Antibacterial activity of Padikara Parpam using agar well diffusion method.
Place and Duration of Study: Central Research Laboratory, Meenakshi Academy of higher Education and Research, Chennai, between June 2021 and November 2021.
Methodology: Clinical isolates of ESBL were isolated by subculture into MacConkey agar and was identified by phenotypic confirmatory test. Padikara parpam's antibacterial activity was evaluated using the Agar well diffusion method at different concentrations of 0.5 %, 1 %, 1.5 %, and 2 % drugs. 30 µg Cefotaxime and 30 µg amoxicillin-clavulanic acid disk were used as controls to standardize the antibacterial activity test and to identify the ESBL by phenotypic confirmatory test.
Results: In this study, Padikara parpam at various doses of 0.5 %, 1 %, 1.5 %, and 2 %, revealed significant antibacterial efficacy against ESBL producing bacteria. Padikara parpam was more active against ESBL Escherichia coli than ESBL Klebsiella pneumoniae. As a result, it may be recommended as an antibacterial agent against ESBL.
Conclusion: Our findings suggest that Siddha Herbo mineral formulations of padikara parpam hold phenomenal antimicrobial activity against ESBL producing bacteria. Based on our findings, the drug may be prescribed successfully for urinary tract infections, which is caused by ESBL producing bacteria.
Frequency of Leading Factors of Severe Acute Malnutrition in Children Below Five Years of Age Attending National Institute of Child Health, Karachi
Authors: Khokhar Iqra Rafique , Ibrahim Mohsina Noor , Khan Sanam , Farhat Aiysha , Jamil Farah , Chohan Muhammad Nadeem 
Published: January 2022

Aim: To determine the frequency of leading factors of severe acute malnutrition in children below five years of age.
Study Design: Cross-sectional study.
Place and Duration of Study: Outpatient department, National Institute of Child Health (NICH) Karachi from December 7, 2017 to June 9, 2018.
Methodology: All children of 6 months to 5 years of age of either gender presented with severe acute malnutrition were included. Information regarding age, gender, weight, height and all leading factors of severe acute malnutrition were noted.
Results: Out of total 157 children, pre-maturity was observed in 21 (13.4%) children, low birth weight in 84 (53.5%) children, anemia in 105 (66.9%) children, lack of complete immunization in 81 (51.6%) children, maternal illiteracy 96 (61.1%), paternal illiteracy 31 (19.7%), low income 116 (73.9%), lack of exclusive breastfeeding in 87 (55.4%) children, administration of Pre-lacteals as the first feeding in 54 (34.4%) whereas initiation of complementary feeding after nine months was observed in 48 (30.6%) children.
Conclusion: The presence of low income, anemia, maternal illiteracy, lack of exclusive breastfeeding and low birth weight were the leading factors of severe acute malnutrition in children below the age of five years.
Association of Sub-Clinical Hypothyroidism with Abnormal Levels of Lipid in the Population of Nawabshah, Pakistan
Authors: Aamer Nasrullah , Memon Beenish Ghafar , Rashid Abdul , Makwana Dayaram , Memon Shahzad , Memon Waseem Raja 
Published: January 2022

Aims: Aim of this investigation was to access the association of dyslipidemia with subclinical hypothyroidism.
Methodology: In this cross-sectional investigation, 1948 participants were recruited. Two groups were made; participants up to 18 years were in group A and Subjects over 18 years were incorporated in group 2. They were subdivided into control, subclinical hypothyroid 1, and subclinical hypothyroid 2. SPSS 21 was used for data analysis.
Results: Data of 1619 individuals were analyzed. The mean age of Group A participants was 12.79 ± 2.779, and the mean age of Group B participants was 42.58 ± 18.012. The prevalence of subclinical hypothyroid was found at 13.5 %. Significant differences have been observed while comparing Group A and Group B (P <0.001). Free tetraiodothyronine and Free triiodothyronine also showed a significant difference in both groups. (P<0.05). No significant difference between mean Thyroid-stimulating hormone levels was observed (P>0.05). No significant association between Controls and High-density Lipid values was found between Controls and subclinical hypothyroid.
Conclusion: We conclude that subclinical hypothyroidism leads to increased dyslipidemia. Lower Serum total cholesterol and low-density lipid levels were detected among children and participants under the age of 18 with Thyroid-stimulating hormone greater than 10 mIU/L. Thyroid-stimulating hormone less than 10.0 mIU/L had no lipid abnormalities in subclinical hypothyroid participants.
Rare Presentation of Gall Bladder Adenomyomatosis
Authors: Ishwarya M. , Anantharamakrishnan R. , Kumar K. Senthil , Pranay K. 
Published: January 2022

Introduction: Adenomyomatosis is a benign alterations of gall bladder wall that can be found in 9% of patients. We present a case of gall bladder adenomyomatosis of young male presented with right upper quadrant pain.
Case Report: A 22 year old male admitted with a history of pain over right upper quadrant for 8 months. The patient’s physical examination revealed tenderness over the right hypochondrium region. Contrast enhanced computed tomography showed - gall bladder wall appeared diffusely thickened with multiple small cystic areas noted.
Conclusion: Symptomatic gall bladder adenomyomatosis is an indicator for cholecystectomy, which results in complete disappearance of symptoms. Asymptomatic cases are not an indication for surgery, but the radiological diagnosis must be beyond any doubt. If there is a any diagnostic doubt about the possibility of gall bladder cancer, a cholecystectomy is justified.
Ultrasound-guided Hydrodissection of Sural Nerve for Foot Pain
Authors: Tople Jeshnu Prakash , Bhuyan Deepjit 
Published: January 2022

Background: Sural nerve entrapment is an impor­tant but infrequent cause of pain. The sural nerve provides sensation to the posterolateral aspect of the leg, lateral foot and fifth toe. Sural nerve entrapment can be challenging to treat and can cause significant limitation. We present a case of sural nerve entrapment resistant to conservative management that was effectively treated by percutaneous ultrasound guided hydrodissection of the sural nerve.
Case Report: A 57 year old male came with complaints of pain and tingling sensation on both lower limbs with 50% decrease in sensation to touch (right > left) in lateral aspect of both foot. The patient had tried several conservative modalities with no success. We performed percutaneous ultrasound guided hydrodissection of the sural nerve and the patient reported complete improvement in his pain.
Conclusion: Percutaneous ultrasound guided hydrodissection of the sural nerve, is a safe and effective treatment for patients with sural nerve entrapment that does not respond to conservative therapy. However, studies are needed to elucidate its effectiveness and safety profile.
The Outcome of Photo-Therapy on Serum Calcium Values in Term Neonates: A Cross Sectional Study
Authors: Mulye Sachin , Gulhane Rohini , Meshram Revatdhama J. 
Published: January 2022

Background: In the management of hyperbilirubinemia in neonates, phototherapy is an important treatment modality. Photo-therapy can cause skin rashes, diarrhoea, increase in body temperature, retinal damage and bronze baby syndrome. Photo-therapy is thought to influence serum calcium levels by inhibiting pineal melatonin secretion.
Aims and Objectives: The aim of this research was to see how photo-therapy affected serum calcium values in a term neonate.
Materials and Methods: Over the course of six months, 74 neonates were studied in the neonatology department of a tertiary healthcare centre in Central India.
Results: Calcium values fell in 77 % of the neonates in our sample, but only one case fell into significant symptomatic hypocalcemic range (1 percent).
Conclusion: According to the findings, neonates who are receiving photo-therapy have a higher risk of falling into the hypocalemic range. As a result, neonates should be strictly observed for calcium shifts and treated appropriately.
Case Report: Management and Outcomes of COVID-19 in a Patient with Cirrhosis of Liver
Authors: Kolhe Seema M. 
Published: January 2022

Introduction: The outbreak of coronavirus disease 2019 (COVID-19) has recently become a major problem affecting thousands of individuals around the world. It is understood that a significant proportion of patients infected with COVID-19 have disturbed liver function tests. This is a case report of a patient with liver cirrhosis and COVID-19.
Presenting Complaints and Investigations: A 39 year old female patient was admitted in AVBRH on 06/02/2021 with chief complaint of distension of abdomen, breathlessness, shortness of breath, reduced urine output over last 3 months. She had skin lesions over the hand, foot, abdomen and back with itching since 4 months. Physical examination, blood investigations and abdominal ultrasound showed cirrhosis of liver with gross ascites seen clinically. She had mild splenomegaly and gall bladder was enlarged. Laboratory tests showed elevated total bilirubin level. In peripheral blood examination, RBC count was low (3.66m/cu mm), Haemoglobin level was 8.2 gm/dl, Platelets count was low (1.19 lakh per cu. mm). WBC count was 3600 cu mm. Doctor diagnosed this as the case of cirrhosis of liver with pemphigus vulgaris with COVID-19.
Past History: 6 months ago, patient was admitted in Aarogyadham hospital Yawatmal with chief complaint of abdominal pain, loss of appetites, fever. On ultrasonography, she had splenomegaly for which she took the treatment.
The Main Diagnosis, Therapeutic Intervention and Outcomes: This case was diagnosed as a case of COVID-19 with Cirrhosis of liver. Interferon alpha 2b solution was given for 10 days to help improve the immunity. Tab. Ursoldiolis (ursodeoxycholic acid) was used to dissolve gallstones.
Conclusion: Good clinical assessment, appropriate care, good nursing care by trained nurses and appropriate treatment can save lives even in complicated COVID-19 infected cases.
Factors Associated with the Mental Health of Health Care Workers Exposed to Pandemic-COVID-19
Authors: Yede Kalyani , Chib Shiney , Patil Ragini , Bhatt Neha 
Published: January 2022

Background: Pandemic, COVID is spreading like a wild fire and it has already become a global issue. People all over the world are going through mental trauma due to the current situation of the globe. The most vulnerable situation is of the front line volunteers like doctors, health care workers, social workers who are coming in direct contact with the COVID patients and working in highly risky work environment. Since its inception in December 2019, Novel Corona Virus Disease started spreading rapidly both locally and internationally and looking to the adversity of the disease, World Health Organization (WHO) declared it has pandemic. The aim of this paper is to explore the determinants associated with the Mental Health of Health Care Workers (HCW) during the pandemic Novel Coronavirus (COVID-19). Questionnaire was developed having both demographic questions and questions related to mental health. Data was collected from 433 HCWs who were the front-line workers, involved directly in handling these patients. Questionnaire was classified into two parts; one included the demographic questions and the second part included questions related mental health and occupational stress. These HCW were the front line works and were more vulnerable and were having the high risk of getting affected. Percentage analysis was used to analyse the demographic data. Exploratory factor analysis was used to explore the dimensions related to mental health and occupational strength. Multi regression model was used to check the impact of emerged factors like increased workload, the continuous contact with COVID-19 patients and emotional aspects to mental health and occupational stress.
Results: Value of R2 obtained was 0.778, which means, the derived factors namely Work pressure, optimism ,Risk factor, Emotional Exhaustion , Self control, Discomfort were able to explain 77.8 % of the dependent variable ‘Mental Health’. All the above factors influence Respondent’s Mental Health, as the significant the factors namely work pressure; risk factor and emotional exhaustion are directly proportional to Mental health. Work pressure is the most influencing factor among it. Optimism, self-control and discomfort are inversely proportional to Mental Health of HCW.
Conclusion: Most important emerged from this study was ‘Work Pressure’. Due to the fast spread of this deadly virus, a war like situation has emerged and Health Care Workers are the most vulnerable people as they are serving the patients directly. They are sacrificing their own physical and mental health and are serving the mankind. These people deserves lots of appreciation and salutations.
Molecular Docking and Validation of Methicillin Resistant Staphylococcus aureus Targets against Geninthiocin
Authors: Lakshmi G. S. Subha , Anuf A. Ronaldo , Vincent Samuel Gnana Prakash 
Published: January 2022

Antibiotic resistance has been a serious public health concern in recent years. Methicillin resistant “Staphylococcus aureus” (MRSA) is a superbug that causes life threatening infections of Humanity which is difficult to treat. Geninthiocin is a macrocyclic thiopeptide with a 35-membered core moiety, which was isolated from marine streptomyces sp. ICN19, which has proven potent activity against MRSA. Five target proteins PDB ID: 4YMX, 3ZDS, 3QLB, 4IEN and 1DXL were identified from MRSA for their presumptive action for Geninthiocin. In this study, we used molecular docking and molecular dynamic simulation, in order to validate Geninthiocin’s potential target protein. Target proteins were subjected to ligand-protein docking studies. Based on their docking scores and Hydrogen bonding interactions, two possible proteins 4YMX and 3ZDS were further subjected to simulation strategies to validate the protein-drug interaction. Out of which, homogentisate1,2 dioxygenase turned out to be a possible drug target for Geninthiocin. The compound Geninthiocin could be developed as a potential inhibitor against the target protein homogentisate1,2-dioxygenase for exhibiting an effective antimicrobial activity.
A Prospective Study of Urinary Albumin to Creatinine Ratio and Its Associated Causes
Authors: Govindaraj Jayamathi , Rekha U. Vidhya , Govindaraj Keerthidaa , Bhuminathan S. 
Published: January 2022

Urine albumin-to-creatinine ratio have predictive values for hypertension, diabetes mellitus, renal dysfunction etc. Albumin-to-creatinine ratio represents the severity of proteinuria, indicates high probability of damage to glomerular filtration capacity of the kidney and is of great diagnostic relevance. Emerging data suggested that reduction of albuminuria leads to reduced risk of adverse renal and cardiovascular events but also steps should be taken to suppress albuminuria to prevent future renal and cardiovascular adverse events. This review discusses the association between albuminuria and adverse cardiovascular and renal outcomes in type 2 diabetes and hypertension. This study aimed to review the association between normal ranges of urine albumin-to-creatinine ratio to cardiovascular and all-cause mortality.
Biosynthesis of Polyhydroxyalkanoate by Recombinant Bacteria: A Review
Authors: Gabr Gamal , Hassan Nahla M. M. 
Published: January 2022

Polyhydroxyalkanoates (PHAs), a biodegradable polymer, has many industrial and medical applications such as heart valves, scaffold, suture and drug delivery. Because of their structural diversity and close analogy to plastics, PHAs have gained major interest over the world. Natural isolates, recombinant bacteria, and plants have all been found to improve the quality, quantity, and economics of PHA production. Their biodegradability makes them an especially appealing synthetic plastic substitute. PHB biosynthetic genes phbA, phbB, and phbC are grouped and systematised into a single phbCAB operon. In terms of alignment and clustering of the relevant genes, the PHB pathway varies greatly across bacterial genera. In this regard, the enzymes appear to have a high degree of sequence preservation.
The structural studies further improve the mechanism of action of these enzymes and helped in improving and choosing the good candidates for increased production of PHB.
Therapeutic Opportunities for Headaches and Migraines in Pediatric Populations: A Review
Authors: Raghuvanshi Devanshu Singh , Chaudhary Richa , Singh Nihaal 
Published: January 2022

Headaches, migraine-like episodes, and other associated conditions are increasingly becoming the most frequent occurrence and a threat to the pediatric population in today’s world. It has become the most sought-after therapeutic opportunity in the clinical setting in a way that can help to treat, diagnose and minimize its ill effects or side effects in today’s world which has witnessed all severe forms of diseases and hopefully will witness more severe forms because of the everlasting unhealthy lifestyle and prevalent hypertension which can be maternal or paternal and can affect the newborn as well as all the pediatric age groups in today’s world. Severe forms of Headachin children or pediatric age groups can be a massive challenge for the clinician to identify, diagnose, and provide effective treatment that can be curable in most cases but can be fatal. In pediatric populations, headaches or migraines can result from underlying conditions, pathologies, or effects of maternal and paternal habits or lifestyles that need more attention than the symptom itself. The treatment spectrum ranges from pharmacological interventions to more unconventional options like acupuncture and alternative medicine. All these options are worth considering, as several studies show high efficacy and success rates with each of these conditions and etiology discussed above. In this review, the authors aim to discuss these different therapeutic options and weigh out their pros and cons, which can help in better and effective treatment to control or eliminate this disease.