bluuebunny/crossref_metadata_2025_split huggingface dataset:
Frequency, entity and determinants of fatigue in Charcot–Marie–Tooth disease
Authors: Bellofatto Marta , Bertini Alessandro , Tramacere Irene , Manganelli Fiore , Fabrizi Gian Maria , Schenone Angelo , Santoro Lucio , Cavallaro Tiziana , Grandis Marina , Previtali Stefano C. , Falzone Yuri , Allegri Isabella , Padua Luca , Pazzaglia Costanza , Calabrese Daniela , Saveri Paola , Quattrone Aldo , Valentino Paola , Tozza Stefano , Gentile Luca , Russo Massimo , Mazzeo Anna , Vita Giuseppe , Piacentini Sylvie , Pisciotta Chiara , Pareyson Davide ,   for the Italian CMT Network
Published: November 2022

AbstractBackground and purposeFatigue, a disabling symptom in many neuromuscular disorders, has been reported also in Charcot–Marie–Tooth disease (CMT). The presence of fatigue and its correlations in CMT was investigated.MethodsThe Modified Fatigue Impact Scale (MFIS) was administered to CMT patients from the Italian Registry and a control group. An MFIS score >38 indicated abnormal fatigue. The correlation with disease severity and clinical characteristics, the Hospital Anxiety and Depression Scale and Epworth Sleepiness Scale scores, and drug use was analysed.ResultsData were collected from 251 CMT patients (136 women) and 57 controls. MFIS total (mean ± standard deviation 32 ± 18.3, median 33), physical (18.9 ± 9.7, 20) and psychosocial (2.9 ± 2.4, 3) scores in CMT patients were significantly higher than controls. Abnormal fatigue occurred in 36% of the patients who, compared to patients with normal scores, had more severe disease (median CMT Examination Score 9 vs. 7), more frequent use of foot orthotics (22% vs. 11%), need of support for walking (21% vs. 8%), hand disability (70% vs. 52%) and positive sensory symptoms (56% vs. 36%). Patients with abnormal fatigue had significantly increased frequency of anxiety/depression/general distress (Hospital Anxiety and Depression Scale), somnolence (Epworth Sleepiness Scale), obesity (body mass index ≥ 30) and use of anxiolytic/antidepressant or anti‐inflammatory/analgesic drugs.ConclusionsFatigue is a relevant symptom in CMT as 36% of our series had scores indicating abnormal fatigue. It correlated with disease severity but also with anxiety, depression, sleepiness and obesity, indicating different components in the generation of fatigue. CMT patients' management must include treatment of fatigue and of its different generators, including general distress, sleepiness and obesity.
Flow intermittency affects structural and functional properties of macroinvertebrate communities in alpine streams
Authors: Chanut Pierre C. M. , Drost Annemieke , Siebers Andre Robert , Paillex Amael , Robinson Christopher T. 
Published: November 2022

Abstract

Flow regime is a major determinant of the structure and functioning of aquatic ecosystems. Under climate change, flow intermittency is becoming more prevalent in glaciated alpine catchments, but the effects of increasing dryness on aquatic biodiversity remain largely unknown.

We characterised flow intermittency patterns in 30 streams of a glaciated alpine catchment over 15 months and separated these streams into four intermittency categories: perennial streams, winter‐drying streams, moderately intermittent streams with occasional drying in summer, and periodically intermittent streams with extensive dry periods throughout the year. We then examined how these drying patterns affected structural and functional properties of benthic macroinvertebrate communities, and whether these changes were primarily deterministic or stochastic.

At the taxonomic level, we observed a response at the highest intermittency levels, with α diversity lower and β diversity higher in periodically intermittent streams than in other stream types. This result suggested that local biota were well adapted to intermediate intermittency levels (mostly during winter) but not to high intermittency during summer. In contrast, functional diversity indices at the α and β levels (based on trait abundances) did not differ across intermittency categories. Considering the moderate level of functional redundancy, we interpreted this as an indication that changes in taxonomic diversity may have resulted primarily from stochastic processes.

Analysis of community and trait composition indicated that deterministic selection may indeed have occurred with increased intermittency, but this process was likely to be minor in comparison to stochastic extinctions. Notably, community evenness was highest in periodically intermittent streams and lowest in perennial streams, suggesting that frequent drying prevented competitive exclusion.

Our results suggested that most macroinvertebrate populations are resilient to intermediate intermittency levels but are filtered at high intermittency, irrespective of their resilience capacities. However, more research is needed to clarify the specific roles of different facets of flow regimes, specifically frequency, duration, and timing of intermittency. Understanding the consequences of responses in diversity and community evenness with increasing intermittency on the functional properties of communities will allow better prediction of the future ecological status of alpine stream networks to ongoing environmental change.
Energy cover crops for biogas production increase soil organic carbon stocks: A modeling approach
Authors: Levavasseur Florent , Kouakou Patrice K. , Constantin Julie , Cresson Romain , Ferchaud Fabien , Girault Romain , Jean‐Baptiste Vincent , Lagrange Hélène , Marsac Sylvain , Pellerin Sylvain , Houot Sabine 
Published: November 2022

AbstractEnergy cover crops for biogas production through anaerobic digestion (AD) are inserted between two primary crops. They replace either bare soil or nonharvested cover crops, and their management is usually intensified to produce more biomass. They allow the production of renewable energy as well as digestate, used as an organic fertilizer, without directly competing with food production. Because of the increased biomass production and export and of the return of a digested biomass to the soil, the impact of energy cover crops on soil organic carbon (SOC) is questioned. The objective of this paper was to study the difference in SOC stocks induced by the introduction of energy cover crops for AD coupled with the application of the resulting amount of digestate. We used the AD model Sys‐Metha combined with the soil C model AMG to simulate SOC stocks for 13 case studies in France, with scenarios comparing different intercrop management practices, with or without cover crops, harvested or not. Our results indicated that the higher biomass production of energy cover crops (from 6.7 to 11.1 t DM ha−1) in comparison with nonharvested cover crops (2 t DM ha−1) or bare soil led to higher humified C input (belowground input and digestate), despite the high C fraction exported in AD. This resulted in an increase in SOC stocks in comparison with nonharvested cover crops or bare soil (from 0.01 to 0.12 t C ha−1 year−1 over 30 years). The uncertainties in the model parameters did not modify these results. However, in the case of equal biomass production between energy cover crops and nonharvested cover crops, SOC stocks would be lower with energy cover crops.
‘I'm competitive with myself’: A study of women leaders navigating neoliberal patriarchal workplaces
Authors: Mavin Sharon , Yusupova Marina 
Published: November 2022

AbstractThis paper investigates how women leaders in the UK negotiate claims of being competitive by internalizing competition. Competition is a critical component in neoliberal contexts; yet its gendered implications are under research. Through analysis of 18 women leaders' narratives who directly characterize themselves as ‘competitive with myself,’ we theorize how and why competition is directed at the self. We understand articulations of ‘I'm competitive with myself as a discursive strategy, which functions in the narratives in three interconnected ways. ‘Competitive with myself’ versus ‘competitive with others’ explains how women leaders internalize competition by rejecting competition with others and distancing from the conventional notion of zero‐sum game competition. ‘Competing with myself for perfection’ and ‘Competitive with myself as a protective shield’ explain why women leaders internalize competition—to perfect the self and navigate the double standards of a gendered neoliberal workplace. We argue that ‘competitive with myself’ as a discursive strategy enables women leaders to openly claim competitiveness, (an undesirable performance for women) and simultaneously distance themselves from it. The study contributes understandings of competition as gendered under neoliberalism and in patriarchal men‐dominated leadership roles and workplaces. Through a nuanced discussion of women leaders' narratives, we identify both an obligation to compete and a possible flexing of gender norms in relation to competition.
Assessment of the anti‐hair loss potential of Camellia japonica fruit shell extract in vitro
Authors: You Jiyoung , Woo Jieun , Roh Kyung‐Baeg , Ryu Dehun , Jang Youngsu , Cho Eunae , Park Deokhoon , Jung Eunsun 
Published: November 2022

AbstractObjectiveHair loss is caused by various factors. Impacts of these factors are often overlapped and intensified. Currently, mitigation of hair loss is being studied by proliferating dermal papilla cells (DPCs) and inhibiting deleterious factors such as dihydrotestosterone (DHT) and oxidative stress on hair growth. Camellia japonica (C. japonica) fruit shell is a discarded part. Its biological activity remains to be elucidated. In this study, we investigated the capacity of C. japonica fruit shell extract (CJFSE) for hair loss mitigation.MethodsMTT assay, spheroid culture and quantitative RT‐PCR were performed to observe the proliferative effect of CJFSE on hair follicle dermal papilla cells (HFDPCs). Effects of CJFSE on DHT‐induced hair loss were confirmed by Dkk‐1 ELISA, β‐galactosidase (β‐gal) and 5α‐reductase activity assay. In addition, effects of CJFSE on oxidative stress were confirmed through DPPH and ROS production assays.ResultsCJFSE increased the proliferation and spheroid size of HFDPCs. Expression levels of VEGF‐A, Wnt‐1, c‐Myc and Cyclin D1 were upregulated by CJFSE. CJFSE also suppressed 5α‐reductase activity and DHT‐induced decrease in cell proliferation, Dkk‐1 secretion and β‐gal activity. Moreover, CJFSE showed DPPH scavenging activity and ameliorated hydrogen peroxide‐induced ROS production and β‐gal activity. Finally, gallic acid and protocatechuic acid were observed in CJFSE through HPLC analysis.ConclusionCJFSE has the potential to alleviate hair loss by promoting hair cell growth and suppressing effects of DHT and oxidative stress on hair.
Development and psychometric test of the myRisk mobile application for caries risk assessment
Authors: Detsomboonrat Palinee , Jaroonvechatam Jiranat , Chaiboon Pasut , Urwannachotima Nipaporn 
Published: November 2022

AbstractObjectivesTo develop a caries‐risk assessment application (myRisk app) and assess the psychometric properties based on content validity, construct validity, and how well it classifies the participants into different caries risk groups using caries increments at 10 months.MethodsThe myRisk mobile application was developed using Android Studio 4.1.1. The content validity was assessed by three dental experts. To evaluate construct validity and the prediction of future dental caries, the participants (N = 88) were recruited from Rajvithi Home for Girls in Thailand by convenience sampling. The participants were completed a caries risk assessment (CRA) of myRisk app and ADA form. The oral examination was performed at the time of CRA and 10 months following the baseline.ResultsEighty‐eight participants aged 12–29 used the myRisk app and completed the ADA form. The app content validity was acceptable (IOC = 0.67). According to myRisk, 7.9%, 71.6%, and 20.5% of the participants were classified into the low‐, moderate‐, and high‐risk groups, respectively. The percent agreement of the caries‐risk classification with the ADA form was 30.7%. Significant differences between the three risk groups were found in active caries (p < 0.001), type, and frequency of sugary snacks (p = 0.002). The app had a sensitivity of 68%, a specificity of 61%, and an area under the receiver operating characterisitic (ROC) curve of 0.61.ConclusionsThe myRisk app has acceptable content validity and sufficient diagnostic accuracy (sensitivity, specificity, and ROC curve). However, there is a different outcome in caries‐risk classification compared with the ADA form.
Monkeypox: a new global health emergency with predominant dermatological manifestations
Authors: Dogra Sunil , Mehta Hitaishi , Gupta Smriti , Suri Vikas 
Published: November 2022

AbstractMonkeypox is a zoonotic virus belonging to the Orthopoxvirus genus. Previously endemic to Africa, outbreaks have been reported from all over the world, the largest of which is currently ongoing. Dermatologists are principally involved in recognition and diagnosis of the infection. This narrative review primarily focuses on clinical manifestations and highlights the unique epidemiological features of current outbreak. Lesions observed during the current outbreak lack the evolution described in endemic disease. Polymorphic lesions are common and may be confined to anogenital area. Onset of “prodromal” symptoms may coincide with onset of skin rash, and these may be altogether absent. Mortality rates observed are low. The exanthem should be differentiated from other infections such as herpes, molluscum contagiosum, smallpox, and other poxvirus infections. Presentation as an isolated genital lesion warrants differentiation from syphilis, chancroid, and other sexually transmitted diseases. Close intimate contact during sexual encounters is the primary mode of transmission, and other coexisting sexually transmitted infections are frequently diagnosed.
Distinctive negative reactions to intermediate social groups
Authors: Burke Sara E. , Perry Sylvia P. , Dovidio John F. , LaFrance Marianne 
Published: November 2022

AbstractAlthough considerable research has examined how members of advantaged groups think and feel about disadvantaged groups, fewer studies have examined responses to “intermediate” social groups—groups that are perceived to fall between more commonly acknowledged groups on the same dimension of social identity. We measured judgments of intermediate groups, including novel groups designed to manipulate social group intermediacy (Studies 1–5), Black/White biracial people (Study 6), and bisexual people (Study 7). In each study, participants provided separate evaluations of an intermediate group and two comparison groups (e.g., Black/White biracial people, Black people, White people). Intermediate groups were consistently rated as less conceptually legitimate (e.g., less distinctive, not a “real” group) than other groups. The view that intermediate groups are not “real” groups helped explain negative evaluations of them, and participants who strongly identified with an advantaged ingroup were especially prone to this pattern of judgments. These results are consistent with the idea that an intermediate group can threaten the distinctiveness of a valued ingroup, leading people to dismiss and denigrate the intermediate group. Studying perceptions of intermediate groups facilitates a nuanced account of an increasingly heterogeneous social world.
Performance of two tools for pulmonary vein occlusion assessment with a novel navigation system in cryoballoon ablation procedure
Authors: Qiao Yu , Zhao Zhen , Fu Mingpeng , Cai Xiang , Guo Yulong , Liu Ke , Guo Jinrui , Guo Tao , Niu Guodong 
Published: November 2022

AbstractIntroductionOptimal occlusion of pulmonary vein (PV) is essential for atrial fibrillation (AF) cryoballoon ablation (CBA). The aim of the study was to investigate the performance of two different tools for the assessment of PV occlusion with a novel navigation system in CBA procedure.MethodsIn consecutive patients with paroxysmal AF who underwent CBA procedure with the guidance of the novel 3‐dimentional mapping system, the baseline tool, injection tool and pulmonary venography were all employed to assess the degree of PV occlusion, and the corresponding cryoablation parameters were recorded.ResultsIn 23 patients (mean age 60.0 ± 13.9 years, 56.5% male), a total of 149 attempts of occlusion and 122 cryoablations in 92 PVs were performed. Using pulmonary venography as the gold standard, the overall sensitivity, specificity of the baseline tool was 96.7% (95% confidence interval [CI] 90.0%–99.1%), and 40.5% (95% CI 26.0%–56.7%), respectively, while the corresponding value of the injection tool was 69.6% (95% CI 59.7%–78.1%), and 100.0% (95% CI 90.6%–100.0%), respectively. Cryoablation with optimal occlusion showed lower nadir temperature (baseline tool: −44.3 ± 8.4°C vs. −35.1 ± 6.5°C, p < .001; injection tool: −46.7 ± 6.4°C vs. −38.3 ± 9.2°C, p < .001) and longer total thaw time (baseline tool: 53.3 ± 17.0 s vs. 38.2 ± 14.9 s, p = .003; injection tool: 58.5 ± 15.5 s vs. 41.7 ± 15.2 s, p < .001) compared with those without.ConclusionsBoth tools were able to accurately assess the degree of PV occlusion and predict the acute cryoablation effect, with the baseline tool being more sensitive and the injection tool more specific.
What makes a good mother? Two decades of research reflecting social norms of motherhood
Authors: Schmidt Eva‐Maria , Décieux Fabienne , Zartler Ulrike , Schnor Christine 
Published: November 2022

AbstractOver the past two decades, scholars have investigated a multitude of different aspects of motherhood. This article provides a scoping review of research published from 2001 to 2021, covering 115 Social Science Citation Index‐referenced papers from WEIRD countries, with the aim of reconstructing social norms around motherhood and mothers' responses to them. The analysis is theoretically based on normological and praxeological concepts. The findings reveal five contemporary norms of motherhood that reflect both stability and increasing differentiation, and are related to five types of mothers: the norms of being attentive to the child (present mother), of securing the child's successful development (future‐oriented mother), of integrating employment into mothering (working mother), of being in control (public mother), and of being contented (happy mother). Relying on an intersectional lens, we analyze mothers' heterogeneous responses to these norms of motherhood, and examine how neoliberal demands build on and perpetuate inequalities.
Theory‐based nursing interventions in adults with coronary heart disease: A systematic review and meta‐analysis of randomized controlled trials
Authors: Gok Metin Zehra , Izgu Nur , Gulbahar Eren Merve , Eroglu Hacer 
Published: November 2022

AbstractPurposeThis systematic review and meta‐analysis aimed to synthesize the outcomes of theory‐based nursing interventions for coronary heart disease management.Design and MethodsWeb of Science, Scopus, Science Direct, and PubMed databases were electronically searched from January 2013 to August 2021. The Preferred Reporting Item for Systematic Reviews and Meta‐analyses statement guidelines was followed for this meta‐analysis. Randomized controlled trials on patients with coronary heart disease, using a theory‐based nursing intervention were eligible. Methodological quality was examined by two authors using the Modified Jadad Scale. Based on the heterogeneity test, the results were analyzed using a pool of data with 95% confidence intervals, p‐values, and fixed or random‐effect models (PROSPERO registration number X).FindingsA total of 1030 studies were initially retrieved, and 8 randomized controlled trials were eventually included in the meta‐analysis after screening. The big majority (81.3%) of participants were males, and the mean age was 54.8 (SD = 8.7) years. This meta‐analysis found theory‐based nursing interventions had no significant effect on blood lipid profile, blood pressure, and healthy lifestyle. However, these interventions significantly reduced fasting blood glucose, and body mass index and improved the physical and psychological domains of quality of life.ConclusionsThe evidence from this meta‐analysis reveals that theory‐based nursing interventions have a positive effect on fasting blood glucose, body mass index, and quality of life. However, their effects on blood lipid profile, blood pressure, and a healthy lifestyle are inconclusive. The results of this metanalysis are largely based on a few trials and were limited in terms of the number of outcomes. Conducting well‐designed randomized controlled trials with adequate power is needed to make a firm conclusion on the influence of theory‐based nursing interventions on patient outcomes in the CHD population.Clinical relevanceConsidering the high mortality and morbidity of coronary heart disease, nurses may play a significant role in coronary heart disease management by providing interventions that are based on a certain theoretical framework. This meta‐analysis provides insights into the implementation of theory‐based nursing interventions in heart attack survivors or those newly diagnosed with coronary heart disease led by nurses and lasting longer than 6 months in coronary heart disease. In addition, future studies should consider enhancing the content of training programs for a healthy lifestyle within the theory‐based nursing interventions and compare the effects of these interventions on acute and chronic coronary syndromes.
Developmental trajectories of positivity from mid‐childhood to early adolescence: Family and school environmental predictors
Authors: Wang Meidan , Huebner Eugene Scott , Tian Lili 
Published: November 2022

AbstractThis study examined the heterogeneity in positivity trajectories and the predictive roles of family and school environments (i.e., perceived parental warmth and basic psychological need satisfactions at school) from mid‐childhood to early adolescence. Elementary school students in China (N = 2204, 54.9% boys, Mage = 9.47 years) completed relevant measures on six occasions, every 6 months. Latent class growth modeling revealed four heterogeneous developmental trajectories of positivity: High‐Increasing (50.6%), Moderate Low‐Increasing (33.2%), Low‐Stable (11.0%), and High‐Decreasing (5.2%). Perceived parental warmth and satisfaction of relatedness and competence needs at school significantly predicted trajectory class membership. Findings underscore the value of identifying group difference in positivity development in youth and the need for specific interventions targeting their unique characteristics.