bluuebunny/crossref_metadata_2025_split huggingface dataset:
A framework to support the progressive implementation of integrated team-based care for the management of COPD: a collective case study
Authors: Sibbald Shannon L , Misra Vaidehi , daSilva Madelyn , Licskai Christopher 
Published: March 2022

Abstract
Background
In Canada, there is widespread agreement about the need for integrated models of team-based care. However, there is less agreement on how to support the scale-up and spread of successful models, and there is limited empirical evidence to support this process in chronic disease management. We studied the supporting and mitigating factors required to successfully implement and scale-up an integrated model of team-based care in primary care.

Methods
We conducted a collective case study using multiple methods of data collection including interviews, document analysis, living documents, and a focus group. Our study explored a team-based model of care for chronic obstructive pulmonary disease (COPD) known as Best Care COPD (BCC) that has been implemented in primary care settings across Southwestern Ontario. BCC is a quality improvement initiative that was developed to enhance the quality of care for patients with COPD. Participants included healthcare providers involved in the delivery of the BCC program.

Results
We identified several mechanisms influencing the scale-up and spread of BCC and categorized them as Foundational (e.g., evidence-based program, readiness to implement, peer-led implementation team), Transformative (adaptive process, empowerment and collaboration, embedded evaluation), and Enabling Mechanisms (provider training, administrative support, role clarity, patient outcomes). Based on these results, we developed a framework to inform the progressive implementation of integrated, team-based care for chronic disease management. Our framework builds off our empirical work and is framed by local contextual factors.

Conclusions
This study explores the implementation and spread of integrated team-based care in a primary care setting. Despite the study’s focus on COPD, we believe the findings can be applied in other chronic disease contexts. We provide a framework to support the progressive implementation of integrated team-based care for chronic disease management.
DNA methylome-wide association study of genetic risk for depression implicates antigen processing and immune responses
Authors: Shen Xueyi , Caramaschi Doretta , Adams Mark J. , Walker Rosie M. , Min Josine L. , Kwong Alex , Hemani Gibran ,   Genetics of DNA Methylation Consortium, Barbu Miruna C. , Whalley Heather C. , Harris Sarah E. , Deary Ian J. , Morris Stewart W. , Cox Simon R. , Relton Caroline L. , Marioni Riccardo E. , Evans Kathryn L. , McIntosh Andrew M. 
Published: March 2022

Abstract
Background
Depression is a disabling and highly prevalent condition where genetic and epigenetic, such as DNA methylation (DNAm), differences contribute to disease risk. DNA methylation is influenced by genetic variation but the association between polygenic risk of depression and DNA methylation is unknown.

Methods
We investigated the association between polygenic risk scores (PRS) for depression and DNAm by conducting a methylome-wide association study (MWAS) in Generation Scotland (N = 8898, mean age = 49.8 years) with replication in the Lothian Birth Cohorts of 1921 and 1936 and adults in the Avon Longitudinal Study of Parents and Children (ALSPAC) (Ncombined = 2049, mean age = 79.1, 69.6 and 47.2 years, respectively). We also conducted a replication MWAS in the ALSPAC children (N = 423, mean age = 17.1 years). Gene ontology analysis was conducted for the cytosine-guanine dinucleotide (CpG) probes significantly associated with depression PRS, followed by Mendelian randomisation (MR) analysis to infer the causal relationship between depression and DNAm.

Results
Widespread associations (NCpG = 71, pBonferroni < 0.05, p < 6.3 × 10−8) were found between PRS constructed using genetic risk variants for depression and DNAm in CpG probes that localised to genes involved in immune responses and neural development. The effect sizes for the significant associations were highly correlated between the discovery and replication samples in adults (r = 0.79) and in adolescents (r = 0.82). Gene Ontology analysis showed that significant CpG probes are enriched in immunological processes in the human leukocyte antigen system. Additional MWAS was conducted for each lead genetic risk variant. Over 47.9% of the independent genetic risk variants included in the PRS showed associations with DNAm in CpG probes located in both the same (cis) and distal (trans) locations to the genetic loci (pBonferroni < 0.045). Subsequent MR analysis showed that there are a greater number of causal effects found from DNAm to depression than vice versa (DNAm to depression: pFDR ranged from 0.024 to 7.45 × 10−30; depression to DNAm: pFDR ranged from 0.028 to 0.003).

Conclusions
PRS for depression, especially those constructed from genome-wide significant genetic risk variants, showed methylome-wide differences associated with immune responses. Findings from MR analysis provided evidence for causal effect of DNAm to depression.
Antimicrobial resistance patterns and genetic elements associated with the antibiotic resistance of Helicobacter pylori strains from Shanghai
Authors: Liu Yixin , Wang Su , Yang Feng , Chi Wenjing , Ding Li , Liu Tao , Zhu Feng , Ji Danian , Zhou Jun , Fang Yi , Zhang Jinghao , Xiang Ping , Zhang Yanmei , Zhao Hu 
Published: March 2022

AbstractBackgroundShanghai, in east China, has one of the world’s highest burdens ofHelicobacter pyloriinfection. While multidrug regimens can effectively eradicateH. pylori, the increasing prevalence of antibiotic resistance (AR) inH. pylorihas been recognized by the WHO as ‘high priority’ for urgent need of new therapies. Moreover, the genetic characteristics ofH. pyloriAR in Shanghai is under-reported. The purpose of this study was to determine the resistance prevalence, re-substantiate resistance-conferring mutations, and investigate novel genetic elements associated withH. pyloriAR.ResultsWe performed whole genome sequencing and antimicrobial susceptibility testing of 112H. pyloristrains isolated from gastric biopsy specimens from Shanghai patients with different gastric diseases. No strains were resistant to amoxicillin. Levofloxacin, metronidazole and clarithromycin resistance was observed in 39 (34.8%), 73 (65.2%) and 18 (16.1%) strains, respectively. There was no association between gastroscopy diagnosis and resistance phenotypes. We reported the presence or absence of several subsystem protein coding genes includinghopE,hofF,spaB,cagYandpflA, and a combination of CRISPRs, which were potentially correlated with resistance phenotypes. TheH. pyloristrains were also annotated for 80 genome-wide AR genes (ARGs). A genome-wide ARG analysis was performed for the three antibiotics by correlating the phenotypes with the genetic variants, which identified the well-known intrinsic mutations conferring resistance to levofloxacin (N87T/I and/or D91G/Y mutations ingyrA), metronidazole (I38V mutation infdxB), and clarithromycin (A2143G and/or A2142G mutations in 23S rRNA), and added 174 novel variations, including 23 non-synonymous SNPs and 48 frameshift Indels that were significantly enriched in either the antibiotic-resistant or antibiotic-susceptible bacterial populations. The variant-level linkage disequilibrium analysis highlighted variations in a protease Lon with strong co-occurring correlation with a series of resistance-associated variants.ConclusionOur study revealed multidrug antibiotic resistance inH. pyloristrains from Shanghai, which was characterized by high metronidazole and moderate levofloxacin resistance, and identified specific genomic characteristics in relation toH. pyloriAR. Continued surveillance ofH. pyloriAR in Shanghai is warranted in order to establish appropriate eradication treatment regimens for this population.
Comparison of efficacy between triamcinolone acetonide and triamcinolone hexacetonide for intraarticular therapy in juvenile idiopathic arthritis: a retrospective analysis
Authors: Chun Angela , Muhammad Lutfiyya N. , De Ranieri Deirdre 
Published: March 2022

Abstract
Background
There are many FDA-approved corticosteroid preparations available for intra-articular injection, however triamcinolone hexacetonide is not one of them. It was the intraarticular drug of choice among pediatric rheumatologists up until approximately a decade ago, when production of this medication ceased. It can be obtained in the United States and Canada via importation from Europe, but it is not FDA-approved at this time. We wish to compare the duration of remission of intraarticular triamcinolone hexacetonide (TH) with that of triamcinolone acetonide (TA) in children with juvenile idiopathic arthritis (JIA) and demonstrate its safety in this population.

Methods
This retrospective chart review included 39 patients with JIA who received intraarticular corticosteroid injections (IACIs) from September 2018 to September 2019. These patients were reviewed and their life-time injections with either TH (41 joints) or TA (124 joints) was noted through May 30, 2021. Patients with concomitant systemic therapy initiation were excluded. The primary outcome was time to relapse. Relapse was defined by the presence of arthritis on physical examination by an attending rheumatologist. Kaplan–Meier curves and a log-rank test were constructed to compare the probability of time to relapse between IACI injections. Additionally, mixed effects cox regression models were constructed to account for multiple injections per participant.

Results
Kaplan–Meier estimator of median relapse time in months was higher for TH. Based on the log-rank test, TA joints had a higher probability of experiencing a relapse during the study time (p value < 0.001). The hazard of time to relapse was reduced when comparing TH to TA in both unadjusted and adjusted mixed effects cox regression models [unadjusted hazard ratio (95% confidence interval): 0.184 (0.089, 0.381); adjusted hazard ratio (95% confidence interval): 0.189 (0.092, 0.386)].

Conclusions
TH has longer duration of action than TA and is associated with less systemic side effects. It should be considered the drug of choice for intraarticular corticosteroid injections in children with JIA.
Cytogenetic abnormalities in a sample of females with premature ovarian failure
Authors: Issa Noha M. , Elhady Ghada M. 
Published: March 2022

AbstractBackgroundPremature ovarian failure (POF) is a complex heterogeneous disorder characterized by the triad of amenorrhea, hypergonadotropinism, and hypoestrogenism in women before the expected age of menopause. In most POF patients, the etiology is idiopathic. X chromosome abnormalities are known to be responsible for many POF cases but the effect of sex chromosome low level mosaicism on ovarian function still remains unclear. The aim of this study was to investigate the prevalence and type of cytogenetic abnormalities as well as low-level sex chromosome mosaicism in Egyptian females with POF.ResultsThe present study recruited thirty women with POF and thirty women with normal reproductive history as a control group. Conventional cytogenetic analysis was carried out on POF patients in order to detect cytogenetic abnormalities. FISH on interphase and metaphase nuclei from patients with normal karyotype as well as from thirty control women with normal reproductive history was performed using X, Y, and 18 centromeric probes to evaluate low-level sex chromosome mosaicism. Conventional cytogenetic analysis of peripheral blood lymphocytes demonstrated chromosomal aberrations in 7 cases. FISH revealed that the rate of X chromosome mosaicism was significantly higher in POF patients than in the control group.ConclusionWe concluded that X chromosome abnormalities including low level mosaicism may be underlying the pathology of POF as increased mosaicism may lead to accelerated oocyte aging and premature follicular atresia.
Federal Reclamation and the American West in the Twentieth Century
Authors: Pisani Donald J. 
Published: March 2022

Abstract
"Federal Reclamation and the American West in the Twentieth Century" looks at four phases in the history of the Bureau of Reclamation. The first phase lasted from the adoption of the Reclamation Act of 1902 into the 1930s. In those years, the bureau attempted to create small family farms by bringing water to the desert lands of the West. That effort failed, in part because farming was becoming less attractive in the United States during the early decades of the 20th century, in part because irrigation was too expensive, and in part because the bureau made many mistakes in administering the 30 projects it created. A second phase of the bureau’s life began in the 1930s, with the "high dam era." From 1930 into the 1950s, the bureau’s mission became inconsistent as it strived to serve a new constituency, city dwellers and industries on the Pacific Coast, at the same time it continued to push the family farm. The bureau entered a third phase of life after World War II, when the power it generated became identified with winning the Cold War against the Soviet Union and agribusiness eclipsed the family farm in the West. Finally, once big dams began to look too expensive and like "old technology," the bureau recreated itself into an agency which now claims to work in the interest of protecting the environment and serving as the West’s "water broker." The Bureau of Reclamation, which has done as much as any federal agency to build the modern American West, has shown an amazing ability to pursue inconsistent objectives and to recreate itself.
Evaluation of pediatric flatfoot treatment results with new type of implant
Authors: Kwiatkowski Michał , Guszczyn Tomasz , Hermanowicz Adam , Borkowska Karolina , Grajewska Anna , Krasowska Dominika , Rysiak Edyta 
Published: March 2022

Wstęp i cel:
Od wielu lat poszukiwane są optymalne sposoby leczenia stopy płasko-koślawej. Podsumowując najnowsze doniesienia medyczne coraz częściej metodą z wyboru przy zaburzeniach dynamicznych są zabiegi małoinwazyjne polegające na podparciu i stabilizacji przemieszczonej kości skokowej za pomocą implantu wprowadzonego do zatoki stępu. Celem pracy jest ocena wyników leczenia stopy płasko-koślawej w dwóch grupach pacjentów operowanych z użyciem różnych typów implantu.
Materiały i metody:
Badaniem objętych zostało 120 pacjentów, leczonych z powodu stopy płasko-koślawej. U wszystkich dzieci zastosowano stabilizację kości skokowej przy pomocy tytanowego implantu wprowadzonego do zatoki stępu. Pacjenci zostali podzieleni na 2 grupy badawcze zgodnie z rodzajem zastosowanego implantu. Pacjentów zbadano klinicznie, wykonano retrospektywną analizę dokumentacji medycznej i obrazów radiologicznych przed- i pooperacyjnych. Chód po korekcji wady został poddany analizie w laboratorium chodu. Porównane zostały obciążenia i nacisk poszczególnych składowych stopy operowanej.
Wyniki:
W badaniu klinicznym zaobserwowano poprawę wyglądu i funkcji stopy w obu grupach. Na obrazach radiologicznych pooperacyjnych u ok 78% pacjentów wynik pomiarowy kątów mieścił się w granicy normy. W obu grupach obciążenia i nacisk poszczególnych składowych stóp operowanych uzyskały znaczącą poprawę, nie wykazano różnic.
Wnioski:
Korekcja stopy płasko-koślawej u dzieci przy pomocy implantu poprawia kosmetykę stopy, wpływa na zmniejszenie dolegliwości bólowych. Wydłużenie rozcięgna mięśnia brzuchatego u części przypadków jest zabiegiem niezbędnym i znacząco wpływa na poprawę ruchomości stopy oraz efekt końcowy.
Does Losing Lead to Winning? An Empirical Analysis for Four Sports
Authors: Klein Teeselink Bouke , van den Assem Martijn J. , van Dolder Dennie 
Published: March 2022

Berger and Pope (2011) show that being slightly behind increases the likelihood of winning in professional (National Basketball Association; NBA) and collegiate (National Collegiate Athletic Association; NCAA) basketball. We extend their analysis to large samples of Australian football, American football, and rugby matches, but find no evidence of such an effect for these three sports. When we revisit the phenomenon for basketball, we only find supportive evidence for NBA matches from the period analyzed in Berger and Pope (2011) . There is no significant effect for NBA matches from outside this sample period, for NCAA matches, or for matches from the Women’s National Basketball Association. High-powered meta-analyses across the different sports and competitions do not reject the null hypothesis of no effect of being slightly behind on winning. The confidence intervals suggest that the true effect, if existent at all, is likely relatively small. This paper was accepted by Manel Baucells, behavioral economics and decision analysis. Funding: The authors acknowledge support fromthe Dutch Research Council. Supplemental Material: The data files and online appendix are available at https://doi.org/10.1287/mnsc.2022.4372 .
Preparation for traumatic events prior to exposure for service personnel
Authors: Griffith Kristin A , Lewis Frances Marcus , Alzawad Zainab 
Published: March 2022

Introduction: Military personnel, first responders and health professionals on the front line of service are at risk of being exposed to non-mutable traumatic events. However, their professional education and training do not typically include ways to minimise their distress caused by witnessing a future trauma. The purpose of this scoping systematic review is to analyse the impact of intervention studies on measures of psychobehavioural adjustment to exposure to a future traumatic event. Materials and methods: A systematic search was conducted using PubMed, CINAHL, PsycINFO and the Cochrane Library plus a hand search of five journals, including Military Medicine and Journal of Trauma. Results: A total of 100 articles from an initial pool of 15 306 were assessed for inclusion on criteria and 10 manuscripts meeting the inclusion criteria were evaluated. Interventions focused on combating stress, relaxation techniques, resilience training, psychological skills training, preventing psychological morbidity or post-traumatic stress disorder, and stress management skills. Conclusions: Only 50% of the interventions significantly changed any outcomes. Studies had multiple methodological limitations including a limited number of training hours, trial bias, statistically underpowered designs, short follow-up periods and using inconsistent methods and measures to assessed impact. The paucity of preparatory intervention studies shows there is an urgent need for future research.
Ultra-broadband perfect absorber using triple-layer nanofilm in a
long-wave near-infrared regime
Authors: Kuang Kaili , Wang Qiao , Yuan Xiaomin , Yu Li , Liang Yuzhang , Zhang Yang , Peng Wei 
Published: March 2022

Plasmonic absorbers have received considerable attention because of their promising
applications in solar cells, controllable thermal emission, and
infrared detection. Most proposed plasmonic absorbers are fabricated
with a precisely designed surface-pattern, which require complex
manufacturing process and are costly. Herein, we propose a simple
plasmonic absorber composed of a triple-layer

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nanosystem. The maximal absorption
reaches 99.8% from 1554 nm to 1565 nm, and an average absorption of
95.3% is achieved in the long-wave near-infrared range (from 1100 nm
to 2500 nm). The synergistic effect of the upper surface plasmon
resonance and the Fabry–Perot resonance in the

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cause the high absorption.
Additionally, the effects of the incident angle, polarization state,
structural materials, and geometric parameters on the absorption
performance are investigated in detail. The proposed near-infrared
absorber has potential application prospects in solar collectors,
thermal emitters, and solar cells, owing to its high absorption,
ultra-broadband bandwidth, insensitivity to incident angle and
polarization state, low cost, and simple preparation process.
Internal phase control of coherent fiber laser array without ambiguous phase based on double wavelength detection
Authors: Chang Hongxiang , Su Rongtao , Chang Qi , Long Jinhu , Ma Pengfei , Ma Yanxing , Zhou Pu 
Published: March 2022

High-power fiber lasers have been widely utilized in manufacturing, medical care, and many other fields. Due to mode instability, nonlinear effects, and so on, the output power of a monolithic fiber laser is limited. Coherent beam combining (CBC) of fiber lasers is a promising way to obtain higher output power. An all-fiber CBC structure with internal phase detection has a compact construction and potential for a larger fiber laser array. For the existing internal active phase control of an all-fiber structure,

π

phase ambiguity always occurs because of double passing the fiber path. Additional compensation is needed under this condition, and the compactness of the system will decrease. In this paper, internal phase control of an all-fiber structure based on double wavelength detection without

π

-ambiguity is proposed. By adding a beacon laser with a different wavelength, phase locking of a coherent fiber laser array can be achieved internally without

π

-ambiguity. A corresponding math model is established, and a phase matched condition is derived. The spectral width of the beacon laser is analyzed, and the result shows that it can reach tens of nanometers with a proper optical path difference. Simulations of seven, 19, and 37 beams are carried out, and the results show that the structure proposed in this paper has the ability to achieve phase control with good robustness. The control bandwidth in the simulation is better than 1 kHz. By properly designing elements, the structure is expected to achieve high-power CBC of an all-fiber structure experimentally.
Authoritative parenting stimulates academic achievement, also partly via self-efficacy and intention towards getting good grades
Authors: Hayek Joyce , Schneider Francine , Lahoud Nathalie , Tueni Maya , de Vries Hein 
Published: March 2022

BackgroundThe aim of this prospective study is to examine how parenting style relates to academic achievement of Lebanese adolescents and test the mediating effect of self-efficacy and intention towards getting good grades. Potential moderation by demographic factors (age, gender, school type, religion and parents’ education) was also examined.MethodsStudents (n = 345) from private and public schools in Mount Lebanon and Beirut area, aged between 15 and 18, participated in a two-wave longitudinal study and completed a self-administered questionnaire based on the I-Change Model assessing socio-demographics (age, gender, school type, parents’ education, family structure, religion), socio-cognitive factors (attitude, social norms, self-efficacy, intention), parenting styles and academic achievement. Adolescent were surveyed at two time points, six months apart. A multiple linear regression was carried out to identify baseline factors independently associated with academic achievement 6 months later. Moderation was examined using Hayes’s SPSS macro PROCESS. A serial mediation model was employed to test for the sequential mediating effect of self-efficacy and intention between parenting style and academic achievement.ResultsAuthoritative parenting was prospectively associated with better academic achievement and higher self-efficacy and intention at 6 months follow up. In addition, self-efficacy and intention towards getting good grades were found to mediate the relationship of parenting style to academic achievement. Adolescents who perceive their parents as authoritative are more likely to develop high efficacy beliefs and higher intention and subsequently are more likely to achieve better in school compared to peers of neglectful parents. Socio-demographics did not moderate the effect of parenting on academic achievement.ConclusionAuthoritative parenting influenced both directly and indirectly the academic achievement of their children. Interventions aiming at improving academic performance of adolescents should also encompass positive parenting style strategies.