bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bruceine D Sensitizes Human Ovarian Cancer Cells to Paclitaxel Through JNK and STAT3 Signal Regulation
Authors: Yan Zhipeng , Jin Zhihong , Sui Hongying , Peng Kehong , Shi Caixia 
Published: March 2022

AbstractExploring novel regimens is essential to ensure the efficacy of paclitaxel-based chemotherapy in epithelial ovarian cancer. Brucea javanica (L.) Merr., Simaroubaceae, oil emulsion benefits the patients who received sequential chemotherapy, and bruceine D is identified as the major active tetracyclic quassinoid. On this premise, we explored the potential effects and related molecular mechanisms of bruceine D on epithelial ovarian cancer cells. Our study indicated an inhibitory effect of bruceine D treatment in epithelial ovarian cancer cells. Increased cell apoptosis and cancer stem cell elimination were observed with combined treatment of bruceine D and paclitaxel in ovarian cancer cells. Mechanism study indicated that JNK and STAT3 signaling regulation contributed to the synergistic effects of bruceine D in paclitaxel-based chemotherapy. Our study revealed a synergistic effect of bruceine D in paclitaxel-based chemotherapy. Our investigation provided a valuable strategy to enhance the efficiency of chemotherapy in ovarian cancer.
Graphical abstract
Does Frege Have Aristotle's Number?
Authors: KATZ EMILY 
Published: March 2022

AbstractFrege argues that number is so unlike the things we accept as properties of external objects that it cannot be such a property. In particular, (1) number is arbitrary in a way that qualities are not, and (2) number is not predicated of its subjects in the way that qualities are. Most Aristotle scholars suppose either that Frege has refuted Aristotle's number theory or that Aristotle avoids Frege's objections by not making numbers properties of external objects. This has led some to conclude that Aristotle's accounts of arithmetical and geometrical objects differ substantially. I close this supposed gap by showing that Aristotle's arithmetical objects, like geometrical objects, are just certain sensible things qua certain properties they in fact possess. Specifically, numbers are pluralities qua quantitative or relational properties like ten units or ten. I show that this view is resistant to the Fregean concerns about arbitrariness and numerical predication.
Reassessing Local Candidate Effects
Authors: Sevi Semra , Mendoza Aviña Marco , Blais André 
Published: March 2022

AbstractIn a seminal article published in 2003, Blais et al. demonstrated that local candidates mattered for about 5 per cent of voters in the 2000 Canadian federal election. This study's reliance on a single election raises external validity concerns. We replicate Blais et al.'s original analyses on four elections from 2000 to 2008 using a decade's worth of data from the Canadian Election Study. The local candidate effect first uncovered by Blais et al. is not specific to a single election. Local candidates are a decisive consideration for about 5 to 8 per cent of voters outside Quebec and for about 2 to 5 per cent of voters in Quebec.
Mental and physical health profile of Syrian resettled refugees
Authors: Bosson Rahel S. , Williams Monnica T. , Powers Victoria A. , Carrico Ruth M. , Frazier Virginia , Ramirez Julio A. , Schneider Wei Shuang , Hooper Lisa M. 
Published: March 2022

Abstract

Background:
Newly arriving Syrian refugees can present with specific health characteristics and medical conditions when entering the United States. Given the lack of epidemiological data available for the refugee populations, our study examined the demographic features of Syrian refugees resettled in the state of Kentucky. Specifically, we examined mental and physical health clinical data in both pre-departure health screenings and domestic Refugee Health Assessments (RHA; Kentucky Office for Refugees, n.d.) performed after resettlement.

Method:
The current study adopted a cross-sectional research design. We analyzed outcome data collected from participants from 2013 and 2015. Specifically, a comparative cross-sectional analysis was performed using clinical data from Syrian refugees who underwent an RHA as part of the resettlement process between January 2015 and August 2016. Those data were compared to data derived from refugees from other countries who resettled in Kentucky between 2013 and 2015.

Results:
Mental health screenings using the Refugee Health Screener (RHS-15; Hollifield et al., 2013) found that 19.5% (n = 34) of adult Syrian refugees reported signs and symptoms from posttraumatic stress, depressive symptoms, and/or anxiety, and nearly 40% (n = 69) reported personal experiences of imprisonment or violence, and/or having witnessed someone experiencing torture or violence. Intestinal parasites and lack of immunity to varicella were the most prevalent communicable diseases among Syrian refugees. Dental abnormalities and decreased visual acuity account for the first and second most prevalent non-communicable conditions. When comparing these results to all refugees arriving during the same years, significant differences arose in demographic variables, social history, communicable diseases, and non-communicable diseases.

Conclusion:
This study provides an initial health profile of Syrian refugees resettling in Kentucky, which reflects mental health as a major healthcare concern. Posttraumatic stress and related symptoms are severe mental health conditions among Syrian refugees above and beyond other severe physical problems.
‘Play the Rain Down’: Prince, Paul Morton, and the Idea of Black Ecstasy
Authors: SHELLEY BRAXTON 
Published: March 2022

AbstractThis article grapples with ‘Let It Rain’, the title track of Bishop Paul S. Morton and the Full Gospel Baptist Church Fellowship's 2003 release, which revises Michael Farren's contemporary Christian ballad by braiding it together with Prince's ‘Purple Rain’ and the formal logic of Black gospel tradition. As the Full Gospel version of this song commingles these seemingly discordant components, Morton, choir, and band turn a sung prayer into an assertion of interworldly presence. Building on its received musical materials, this gospel power ballad performs the Black gospel tradition's characteristic inflection – an arresting turn from one level of musicking to a heightened, ecstatic frame. In so doing, this song brings rain near, illuminating the links between performances of musical ecstasy and musical Blackness.
Design of low profile high gain antenna using loop-based wideband artificial magnetic conductor for UWB applications
Authors: Dwivedi Ravi Prakash , Kiran Kommuri Usha , Das Sudipta , Lakrit Soufian , Goyal Vishal 
Published: March 2022

AbstractIn this work, a low profile ultra-wideband (UWB) antenna is designed and investigated using a novel loop-based wideband artificial magnetic conductor (WB-AMC) for gain enhancement. Initially, a compact loop antenna is designed using stub loading and further optimized for the UWB range by applying curve ground methodology. The average gain of the proposed antenna without WB-AMC is 2.7 dBi. To enhance the gain of the entire UWB range, loop-based WB-AMC in [2 × 2] forms is integrated. WB-AMC is used as a ground plane beneath the antenna. To validate the performance, the UWB antenna and WB-AMC are fabricated and tested. The measured results confirm the entire UWB range. Proposed antenna provides a peak gain of 9.4 dBi and an average gain of 5.8 dBi. Vertical profile reduction of 50% is achieved compared to perfect electric conductor ground. The proposed UWB antenna is a potential candidate for UWB wireless applications due to its attractive features such as low profile, wide bandwidth coverage, omnidirectional pattern, constant high gain, and group delay.
Effect of LRRK2 protein and activity on stimulated cytokines in human monocytes and macrophages
Authors: Ahmadi Rastegar Diba , Hughes Laura P. , Perera Gayathri , Keshiya Shikara , Zhong Siying , Gao Jianqun , Halliday Glenda M. , Schüle Birgitt , Dzamko Nicolas 
Published: March 2022

AbstractLeucine-rich-repeat kinase 2 (LRRK2), a potential therapeutic target for the treatment of Parkinson’s disease (PD), is highly expressed in monocytes and macrophages and may play a role in the regulation of inflammatory pathways. To determine how LRRK2 protein levels and/or its activity modulate inflammatory cytokine/chemokine levels in human immune cells, isogenic human induced pluripotent stem cells (iPSC) with the LRRK2-activating G2019S mutation, wild-type LRRK2, and iPSC deficient in LRRK2 were differentiated to monocytes and macrophages and stimulated with inflammatory toll-like receptor (TLR) agonists in the presence and absence of LRRK2 kinase inhibitors. The effect of LRRK2 inhibitors and the effect of increasing LRRK2 levels with interferon gamma on TLR-stimulated cytokines were also assessed in primary peripheral blood-derived monocytes. Monocytes and macrophages with the LRRK2 G2019S mutation had significantly higher levels of cytokines and chemokines in tissue culture media following stimulation with TLR agonists compared to isogenic controls. Knockout of LRRK2 impaired phagocytosis but did not significantly affect TLR-mediated cytokine levels. Interferon gamma significantly increased the levels of LRRK2 and phosphorylation of its downstream Rab10 substrate, and potentiated TLR-mediated cytokine levels. LRRK2 kinase inhibitors did not have a major effect on TLR-stimulated cytokine levels. Results suggest that the LRRK2 G2019S mutation may potentiate inflammation following activation of TLRs. However, this was not dependent on LRRK2 kinase activity. Indeed, LRRK2 kinase inhibitors had little effect on TLR-mediated inflammation under the conditions employed in this study.
Robust behavior and spin-texture stability of the topological surface state in Bi2Se3 upon deposition of gold
Authors: Clark O. J. , Freyse F. , Yashina L. V. , Rader O. , Sánchez-Barriga J. 
Published: March 2022

AbstractThe Dirac point of a topological surface state (TSS) is protected against gapping by time-reversal symmetry. Conventional wisdom stipulates, therefore, that only through magnetisation may a TSS become gapped. However, non-magnetic gaps have now been demonstrated in Bi2Se3 systems doped with Mn or In, explained by hybridisation of the Dirac cone with induced impurity resonances. Recent photoemission experiments suggest that an analogous mechanism applies even when Bi2Se3 is surface dosed with Au. Here, we perform a systematic spin- and angle-resolved photoemission study of Au-dosed Bi2Se3. Although there are experimental conditions wherein the TSS appears gapped due to unfavourable photoemission matrix elements, our photon-energy-dependent spectra unambiguously demonstrate the robustness of the Dirac cone against high Au coverage. We further show how the spin textures of the TSS and its accompanying surface resonances remain qualitatively unchanged following Au deposition, and discuss the mechanism underlying the suppression of the spectral weight.
A comparative whole-genome approach identifies bacterial traits for marine microbial interactions
Authors: Zoccarato Luca , Sher Daniel , Miki Takeshi , Segrè Daniel , Grossart Hans-Peter 
Published: March 2022

AbstractMicrobial interactions shape the structure and function of microbial communities with profound consequences for biogeochemical cycles and ecosystem health. Yet, most interaction mechanisms are studied only in model systems and their prevalence is unknown. To systematically explore the functional and interaction potential of sequenced marine bacteria, we developed a trait-based approach, and applied it to 473 complete genomes (248 genera), representing a substantial fraction of marine microbial communities. We identified genome functional clusters (GFCs) which group bacterial taxa with common ecology and life history. Most GFCs revealed unique combinations of interaction traits, including the production of siderophores (10% of genomes), phytohormones (3–8%) and different B vitamins (57–70%). Specific GFCs, comprising Alpha- and Gammaproteobacteria, displayed more interaction traits than expected by chance, and are thus predicted to preferentially interact synergistically and/or antagonistically with bacteria and phytoplankton. Linked trait clusters (LTCs) identify traits that may have evolved to act together (e.g., secretion systems, nitrogen metabolism regulation and B vitamin transporters), providing testable hypotheses for complex mechanisms of microbial interactions. Our approach translates multidimensional genomic information into an atlas of marine bacteria and their putative functions, relevant for understanding the fundamental rules that govern community assembly and dynamics.
Molecular basis of specificity and deamidation of eIF4A by Burkholderia Lethal Factor 1
Authors: Mobbs George W. , Aziz Adli A. , Dix Samuel R. , Blackburn G. M. , Sedelnikova Sveta E. , Minshull Thomas C. , Dickman Mark J. , Baker Patrick J. , Nathan Sheila , Raih Mohd Firdaus , Rice David W. 
Published: March 2022

AbstractBurkholderiapseudomallei lethal factor 1 (BLF1) exhibits site-specific glutamine deamidase activity against the eukaryotic RNA helicase, eIF4A, thereby blocking mammalian protein synthesis. The structure of a complex between BLF1 C94S and human eIF4A shows that the toxin binds in the cleft between the two RecA-like eIF4A domains forming interactions with residues from both and with the scissile amide of the target glutamine, Gln339, adjacent to the toxin active site. The RecA-like domains adopt a radically twisted orientation compared to other eIF4A structures and the nature and position of conserved residues suggests this may represent a conformation associated with RNA binding. Comparison of the catalytic site of BLF1 with other deamidases and cysteine proteases reveals that they fall into two classes, related by pseudosymmetry, that present either the re or si faces of the target amide/peptide to the nucleophilic sulfur, highlighting constraints in the convergent evolution of their Cys-His active sites.
Understanding the Independent Predictors of Dysphagia-Related Quality of Life in Stroke Survivors
Authors: Namasivayam-MacDonald Ashwini M. , Ayub Aaliyeh , Najeeb Hiba , Shune Samantha E. 
Published: March 2022

Purpose:It is important to pinpoint modifiable factors contributing to reduced dysphagia-related quality of life (QoL) in order to improve treatment outcomes and patient health given that a large proportion of stroke survivors experience dysphagia. The purpose of this exploratory study was to identify the independent predictors of dysphagia-related QoL in community-dwelling stroke survivors.Method:A sample of 31 adult stroke survivors with dysphagia (Mage= 62 years; 23 males) and their partners (Mage= 57 years; seven males) participated in the study. Survivors were > 3 months poststroke and living with their partner. Backward regression analysis methods were employed to determine independent predictors of dysphagia-related QoL using scores from the Swallowing-Related Quality of Life questionnaire. Independent variables tested included age, employment status, receiving dysphagia treatment, number of medical conditions, level of diet modification, Stroke Impact Scale (SIS) scores, relationship with partner, partner age, partner employment status, partner burden, and partner depression.Results:Results indicated that number of survivor medical conditions, degree of diet modification, SIS emotional subscale score, and partner employment status significantly predicted dysphagia-related QoL (p< .001). More specifically, stroke survivors with more medical conditions or a partner who worked outside of the home had worse dysphagia-related QoL, and those with better mental health or a less modified diet had better dysphagia-related QoL.Conclusion:Factors related to dysphagia-related QoL are multifactorial and include both survivor and spousal variables. The results of this exploratory study highlight the need for clinicians and researchers to consider patient function and needs more wholistically to maximize perceived QoL.
Student Perceptions of Learning-by-Teaching in a Speech Sound Disorders Course
Authors: Mayne Lesley E. , Kim Namhee 
Published: March 2022

Purpose:
The purpose of this mixed method study is to investigate graduate and undergraduate student perceptions of the benefit, content knowledge, and confidence yielded from a learning-by-teaching experience in two Communication Sciences and Disorders courses.

Method:
A total of 137 students, 71 graduate and 66 undergraduate students, enrolled in graduate or undergraduate sections of speech sound disorders courses participated in the study. Graduate students prepared research-based speech sound disorder intervention projects including materials that were briefly presented to undergraduate students and then interactive discussion of theory and practice with the intervention procedures and materials ensued. Pre- and poststudy quantitative and qualitative data collected from surveys of student participant perceptions were analyzed.

Results:
The results yielded benefits in students' satisfaction with the learning experience, content knowledge gains, and confidence as presenters at the graduate level and with implementing intervention at the undergraduate level.

Conclusions:
Potential implications for the learning-by-teaching as a valuable authentic pedagogical model for faculty and students in communication sciences and disorders programs are presented based on 3 years of data. This study offers faculty with a class design model to implement learning-by-teaching in an existing course. Future research can investigate the benefit of embedding authentic learning experiences, such as learning-by-teaching, to formative and summative course measures and students' perceptions of preparation for practicum experiences.
In bestimmter Weise auf jemanden wirken …
Authors: Schleusener Robert 
Published: March 2022

ZusammenfassungOsteopathisch tätige Menschen haben ambitionierte Vorstellungen bezüglich der diagnostischen und therapeutischen Verwertbarkeit ihrer Palpationsbefunde. Von ihnen entwickelte Vorstellungen
und Begrifflichkeiten müssen vor dem Hintergrund aktueller Ergebnisse der Psychologie, der Haptik- und der Placeboforschung be- und überdacht werden. Gleichzeitig für Erfahrungen offen zu
bleiben, die auf einen unkonventionellen Zugang hinweisen könnten, ist herausfordernd. Dieses Fallbeispiel beschreibt eine solche Gratwanderung.
Protonenpumpenhemmer (PPI): Mikronährstoff-Räuber mit
nachhaltigen Nebenwirkungen (Teil 1)
Authors: Gröber Uwe 
Published: March 2022

ZusammenfassungDie längerfristige Einnahme von Protonenpumpeninhibitoren (PPI) ist mit
zahlreichen Risiken verbunden, daher ist der Einsatz der Säureblocker
möglichst auf max. 8 Wochen zu begrenzen. Aufgrund der verringerten
Magensäureproduktion unter PPI siedeln sich vermehrt pathogene Bakterien
im Gastrointestinaltrakt an, es kommt zu verminderter Resorption und Utilisation
von Mikronährstoffen wie Magnesium, Kalzium, Zink, Eisen und Vitamin
B12. Eine Reihe von miteinander vernetzten Pathomechanismen
erhöht das Osteoporose- bzw. Frakturrisiko deutlich. Erste Studien
weisen darauf hin, dass die dauerhafte Blockade der Magensäure das
Risiko für eine Infektion mit SARS-CoV-2 als auch die Schwere des
Krankheitsverlaufs steigert. Die Verabreichung von PPI im 1. Trimenon der
Schwangerschaft scheint nicht mit einem teratogenen Risiko verbunden zu sein, im
Gegensatz zur Einnahme in den 4 Wochen vor der Konzeption. Die Einnahme
während der Gravidität erhöht das Risiko für
kindliches Asthma und Allergien.
Localizing a Covid phone app
Authors: Warburton Kara , Krishnan Kamya Bharthi 
Published: March 2022

Abstract
In this paper we describe how a COVID-19 phone app was localized by students of the MA program in Translation and
Interpreting at the University of Illinois at Urbana-Champaign. The project presented unique challenges including the urgency and
short time-lines, less-than-optimal internationalization of the source code, limitations of the CAT tool, and the use of an
open-source platform and crowd-sourced agile development model, in addition to particular linguistic aspects related to the new
specialized subject matter, limited string context, and potentially sensitive data. On the other hand, it offered the opportunity
to experience a real-life localization project, which had important pedagogical benefits for translation students. These and other
aspects are described and suggestions proposed to enable similar projects to run smoothly.
The potential of seaweed for carbon capture
Authors: Ould Ellen , Caldwell Gary S. 
Published: March 2022

Abstract
Macroalgae (seaweeds) are drawing interest as potential tools for climate mitigation within a burgeoning blue carbon agenda. With the high rates of net primary productivity, they are one of the main carbon sinks in the global ocean, both as biomass standing stock and as vectors of carbon export through detritus pathways. When coupled with their intrinsic ecological value, their contribution to coastal economies, and their current and future scope for aquaculture production, it is perhaps unsurprising that macroalgae have become a focus for nature-based carbon sequestration. However, the research community must guard against the hyperbole that is beginning to permeate the conversation, such as that which beset the microalgae biofuel movement. Macroalgae undoubtedly have a role to play in combating carbon pollution, and perhaps before significant investment is committed to ramping up macroalgae aquaculture, a more pragmatic view of its contribution to natural capital is justified. This article takes an objective look at the capacity for macroalgae to fill a global carbon sequestration niche, both as managed natural carbon pools and as deployable carbon capture assets.
Successful Winter Tourism Destinations
Authors: Johnson Amanda J. , Winkle Christine 
Published: March 2022

Abstract
Climate, whether warm and sunny or cold and snowy, can complement tourism by providing favourable conditions for visitors and their desired activities. As a result, climate is often a main resource upon which tourism destinations depend. Extreme or unpredictable weather may be viewed as unfavourable for attracting visitors. However, even seemingly inclement climate conditions can be used as a resource in tourism. Existing research does not demonstrate how outwardly negative climate conditions might influence destination image, destination selection, and local tourism development. This case study examines how cold climates present both a challenge and an opportunity to developing and promoting an area for tourism. Here we outline how The Forks National Historic Site, located in Winnipeg, Manitoba and a popular summer destination was successfully re-framed as a cold-weather attraction. This case study represents a specific instance of how a tourism destination may highlight a unique feature, such as a frozen river. Readers will understand how harsh weather can become an uncommon resource that facilitates tourism and recreation and enhances overall visitor experience. As such, this case study presents a specific example of how various stakeholders came together to offer a unique experience and transformed an otherwise negative climate condition into a positive and desirable aspect of the destination.

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Vancouver Island University World Leisure Centre of Excellence
© A.J. Johnson and C. Van Winkle, 2015