bluuebunny/crossref_metadata_2025_split huggingface dataset:
Targeted nanotherapy with everolimus reduces inflammation and fibrosis in scleroderma‐related interstitial lung disease developed by PSGL‐1 deficient mice
Authors: González‐Sánchez Elena , Muñoz‐Callejas Antonio , Gómez‐Román Javier , San Antonio Esther , Marengo Alessandro , Tsapis Nicolas , Bohne‐Japiassu Kamila , González‐Tajuelo Rafael , Pereda Saray , García‐Pérez Javier , Cavagna Lorenzo , González‐Gay Miguel Ángel , Vicente‐Rabaneda Esther Francisca , Meloni Federica , Fattal Elias , Castañeda Santos , Urzainqui Ana 
Published: June 2022

Background and PurposeInterstitial lung disease (ILD) is the main cause of mortality in systemic sclerosis (SSc), and current therapies available are of low efficacy or high toxicity. Thus, the identification of innovative less toxic and high efficacy therapeutic approaches to ILD treatment is an urgent need. The interaction of P‐selectin glycoprotein ligand‐1 (PSGL‐1) with P‐selectin initiates leukocyte extravasation and deletion of the corresponding gene (Selplg) induces a SSc‐like syndrome with high incidence of ILD in aged mice.Experimental ApproachAged PSGL‐1 KO (Selplg‐/‐) mice were used to assess the therapeutic effects of nanotherapy with everolimus, included in liposomes decorated with high MW hyaluronic acid (LipHA+Ev) and administered intratracheally to specifically target CD44‐expressing lung cells.Key ResultsPSGL‐1 KO mice had increased numbers of CD45+ and CD45− cells, including alveolar and interstitial macrophages, eosinophils, granulocytes and NK cells, and myofibroblasts in bronchoalveolar lavage (BAL). CD45+ and CD45− cells expressing pro‐inflammatory and pro‐fibrotic cytokines were also increased. Lungs from PSGL‐1 KO mice showed increased immune cell infiltration and apoptosis and exacerbated interstitial and peribronchial fibrosis. Targeted nanotherapy with LipHA+Ev decreased the myofibroblasts in BAL, cells producing proinflammatory and profibrotic cytokines, and the degree of lung inflammation at histology. LipHA+Ev treatment also decreased the severity of peribronchial and interstitial lung fibrosis, from moderate to mild levels.Conclusions and ImplicationsIn PSGL‐1 KO mice, targeted nanotherapy with LipHA+Ev was an effective treatment for SSc‐ILD, reducing the number of inflammatory and fibrotic cells in BAL and reducing inflammation and fibrosis in lungs.
Development of information integration in the visual working memory of preschoolers
Authors: Guo Dong , Wang Yudan , Liao Yifan , Li Jiaofeng , Zhang Xingyi , Gao Zaifeng , Shen Mowei , He Jie 
Published: June 2022

AbstractVisual working memory (WM) plays a pivotal role in integrating fragments into meaningful units, but no study has addressed how visual WM integration takes place in children. The current study examined whether WM integration emerges once preschoolers master Gestalt cue and can retain two representations in WM (automatic integration hypothesis), or still needs time to mature (maturation‐of‐integration hypothesis). Four experiments (N = 168, 81 females, 4‐ to 6‐year‐olds, Chinese, in Hangzhou, China, from 2016.10 to 2021.11) were conducted. Although 4‐year‐olds can retain two objects in WM and benefit from Gestalt cues in simultaneous display (Cohen's ds >1.00), they failed when memory arrays were presented sequentially. Meanwhile, 5‐ and 6‐year‐olds consistently demonstrated WM integration ability (all Cohen's ds >0.69), supporting the maturation‐of‐integration hypothesis.
Menopause, skin and common dermatoses. Part 2: skin disorders
Authors: Kamp Erin , Ashraf Mariha , Musbahi Esra , DeGiovanni Claudia 
Published: June 2022

Abstract
In this second part of a four-part review, we examine the effect of menopause on the skin. Menopause and the associated hypo-oestrogenic state have implications for the structure and function of the skin. We performed a literature review to investigate the impact of the menopause on common dermatoses. There is evidence that oestrogen is implicated in transepidermal water loss and reduction in dermal collagen. There are associations with menopause and multiple common dermatoses, including xerosis and pruritus, hidradenitis suppurativa and psoriasis. Menopause has a clear impact on the skin and common dermatological conditions. Further research to understand the mechanisms and explore therapeutic options is needed.
Effects of connection to nature on residents’ perceptions of conservation policy justice of Natura 2000
Authors: Strzelecka Marianna , Tusznio Joanna , Akhshik Arash , Rechcinski Marcin , Grodzinska‐Jurczak Malgorzata 
Published: June 2022

AbstractWe examined the effects of human connection to nature on residents’ concerns about justice in conservation policies of Natura 2000. Expansion of Natura 2000 conservation network has resulted in local communities having to consider Natura 2000 in their development plans, and justice concerns have been strong in some communities near Natura 2000 sites. We conceptualized Natura 2000 justice within a framework composed of 3 domains of conservation justice: distribution, recognition, and representation. To examine the effect of nature connection on perceived justice of Natura 2000, we conducted a door‐to‐door survey of rural resident (80.09% response rate) in 3 municipalities of Pomerania in Poland. The effect of connection to nature on perceived distribution of Natura 2000 benefits was positive (b = 0.187, t = 7.057, p < 0.001); perceived communication about Natura 2000 was positive (b = 0.089, t = 2.940 p < 0.01); perception of limitations was positive (b = 0.078, t = 2.416, p < 0.01); perceived recognition was positive (b = 0.117, t = 3.367, p < 0.001); and perceived representation was positive (b = 0.123, t = 5.015, p < 0.001). Our results suggest local residents’ bonds with nature matter and they should be considered when new conservation approaches, such as Natura 2000, are introduced.
Social hierarchy effect of political strategy: Exploring chairman's political position influence on independent directors' dissent
Authors: Chen Shihua , Ye Yan , Jebran Khalil , Zhu David H. 
Published: June 2022

AbstractResearch question/issueAlthough the dark side of corporate political connections has been highlighted in recent studies, their adverse consequences on board decision making have received limited research attention. In this study, we posit that the political position of a chairman leads to greater power and a higher ranking on the board, which adversely influences the dissenting behavior of independent directors.Research findings/insightsIn line with our predictions, we show that the presence of a chairman with political position will reduce the likelihood that independent directors will dissent on board proposals. Such influence is particularly weaker in firms that have higher status independent directors on boards and are state owned but stronger among firms in regulated industries and those strongly influenced by Confucian beliefs. These predictions are supported using a sample of Chinese firms from 2004 to 2016.Theoretical/academic implicationsOur findings contribute to the board dynamics and decision‐making literature by highlighting how the political position of a board chairman can adversely affect the decision‐making quality of the whole board by reducing the propensity for independent directors to dissent.Practitioner/policy implicationsThe findings of this work also provide important insights to policymakers who are keen to improve corporate governance mechanisms by designing political strategies for firms.
Validation of cause of death classification after heart transplantation and cause‐specific life expectancy compared to the general population
Authors: Gjesdal Grunde , Lundgren Jakob , Czuba Tomasz , Wareham Neval Ete , Gustafsson Finn , Nilsson Johan , Smith J. Gustav , Braun Oscar Ö. 
Published: June 2022

AbstractBackgroundPost heart‐transplant survival has increased, but information is lacking on specific causes of death and life expectancy. We aimed to assess cause‐specific loss of life‐years compared to the general population, evaluate classification for cause of death after heart transplantation, and assess validity of cause of death data from the International Society of Heart and Lung Transplant (ISHLT) registry.MethodsIn this single center study, we included 239 heart recipients transplanted between 1988 and 2019 in Lund, Sweden (n = 239, 50% of the transplanted population where the cause of death was available). Two cardiologists retrospectively assigned causes of death according to a published classification (CLASS) in the 91 recipients who died during follow‐up. Life expectancy was compared to data from the general population.ResultsCompared to the average Swedish population, life expectancy for heart transplant recipients was 20 years shorter (IQR 12.9–27.2). The largest number of life‐years lost were for deaths due to acute (49 years) and chronic rejection (27 years). Primary graft dysfunction (24 years) accounted for 24% of deaths, followed by malignancy (20 years) and infection (17 years), each accounting for ∼20% of deaths. Use of CLASS revealed moderate inter‐rater agreement (56%) and moderate agreement with the ISHLT registry (62%).ConclusionsSurvival after heart transplantation was 20 years lower than in the general population. In the young, more life‐years were lost due to acute graft rejection, whereas chronic graft rejection and primary graft failure were more important causes of death in older patients. Agreement was moderate between CLASS and the ISHLT registry classifications.
Genome‐wide analysis of hybridization in wild boar populations reveals adaptive introgression from domestic pig
Authors: Mary Nicolas , Iannuccelli Nathalie , Petit Geoffrey , Bonnet Nathalie , Pinton Alain , Barasc Harmonie , Faure Amélie , Calgaro Anne , Grosbois Vladimir , Servin Bertrand , Ducos Alain , Riquet Juliette 
Published: June 2022

AbstractThe admixture of domestic pig into French wild boar populations has been monitored since the 1980s thanks to the existence of a cytogenetic difference between the two sub‐species. The number of chromosomes is 2n = 36 in wild boar and 2n = 38 in pig, respectively. This difference makes it possible to assign the “hybrid” status to wild boar individuals controlled with 37 or 38 chromosomes. However, it does not make it possible to determine the timing of the hybridization(s), nor to guarantee the absence of domestic admixture in an animal with 2n = 36 chromosomes. In order to analyze hybridization in greater detail and to avoid the inherent limitations of the cytogenetic approach, 362 wild boars (WB) recently collected in different French geographical areas and in different environments (farms, free ranging in protected or unprotected areas, animals with 2n = 36, 37 or 38 chromosomes) were genotyped on a 70K SNP chip. Principal component analyses allowed the identification of 13 “outliers” (3.6%), for which the proportion of the genome of “domestic” origin was greater than 40% (Admixture analyses). These animals were probably recent hybrids, having Asian domestic pig ancestry for most of them. For the remaining 349 animals studied, the proportion of the genome of “wild” origin varied between 83% and 100% (median: 94%). This proportion varied significantly depending on how the wild boar populations were managed. Local ancestry analyses revealed adaptive introgression from domestic pig, suggesting a critical role of genetic admixture in improving the fitness and population growth of WB. Overall, our results show that the methods used to monitor the domestic genetic contributions to wild boar populations should evolve in order to limit the level of admixture between the two gene pools.
Fisheries genomics of snapper (Chrysophrys auratus) along the west Australian coast
Authors: Bertram Andrea , Fairclough David , Sandoval‐Castillo Jonathan , Brauer Chris , Fowler Anthony , Wellenreuther Maren , Beheregaray Luciano B. 
Published: June 2022

AbstractThe efficacy of fisheries management strategies depends on stock assessment and management actions being carried out at appropriate spatial scales. This requires understanding of spatial and temporal population structure and connectivity, which is challenging in weakly structured and highly connected marine populations. We carried out a population genomics study of the heavily exploited snapper (Chrysophrys auratus) along ~2600 km of the Australian coastline, with a focus on Western Australia (WA). We used 10,903 filtered SNPs in 341 individuals from eight sampling locations to characterize population structure and connectivity in snapper across WA and to assess if current spatial scales of stock assessment and management agree with evidence from population genomics. Our dataset also enabled us to investigate temporal stability in population structure as well as connectivity between WA and its nearest, eastern jurisdictional neighbour. As expected for a species influenced by the extensive ocean boundary current in the region, low genetic differentiation and high connectivity were uncovered across WA. However, we did detect strong isolation by distance and genetic discontinuities in the mid‐west and south‐east. The discontinuities correlate with boundaries between biogeographic regions, influenced by on‐shelf oceanography, and the sites of important spawning aggregations. We also detected temporal instability in genetic structure at one of our sites, possibly due to interannual variability in recruitment in adjacent regions. Our results partly contrast with the current spatial management of snapper in WA, indicating the likely benefits of a review. This study supports the value of population genomic surveys in informing the management of weakly structured and wide‐ranging marine fishery resources.
Raft platforms highly enriched in cholesterol: major scaffolds for IL‐6 signalling assembly with implications in inflammation and cancer
Authors: Mollinedo Faustino 
Published: June 2022

Interleukin‐6 (IL‐6) is a pleiotropic cytokine with complex and major roles in inflammation, which could be linked to the different ways IL‐6 signals at the plasma membrane. In this issue of FEBS Journal, Woo and co‐workers present evidence for the involvement of Eps15 homology domain‐containing protein 1 (EHD1)‐mediated lipid raft platforms, highly enriched in cholesterol, in the IL‐6 signalling pathway. Because of the strong connection between IL‐6, inflammation and cancer, one implication of this report is that agents or approaches targeting cholesterol‐rich raft platforms may assist the development of novel strategies to treat inflammatory and malignant diseases.Comment on: https://doi.org/10.1111/febs.16458
Assessment of prostaglandin F2‐alpha (PGF2α) in lesional and nonlesional skin of vitiligo patients
Authors: Nagui Noha A. , El‐Tartoushy Samar A. , Rashed Laila A. , Elmasry Maha F. 
Published: June 2022

AbstractBackgroundF2‐isoprostane is one of the members of biologically active prostaglandins. It is considered a reliable marker of oxidative stress. This study aimed at investigating and studying the hypothesis of the possible role of prostaglandin F2‐alpha (PGF2α) in the pathogenesis of vitiligo and to know if there is a possibility of using it in therapy.MethodsThis case–control study involved 30 patients with nonsegmental vitiligo and 30 healthy sex‐ and age‐matched controls over a period of 7 months. Skin biopsies were taken from lesional and nonlesional vitiliginous skin of patients and from normal skin of controls for measurement of PGF2α in tissue by ELISA.ResultsThe tissue levels of PGF2α in vitiligo patients were significantly higher in both lesional and nonlesional skin than in healthy controls (P < 0.001). The tissue levels of PGF2α in lesional skin were significantly higher than in nonlesional skin (P < 0.001).ConclusionBased on the fact that PGF2α is a reliable biomarker of oxidative stress, in addition to our results that revealed higher tissue levels of PGF2α in vitiliginous skin than in healthy skin, we can conclude that PGF2α may be incriminated in the pathogenesis of vitiligo. This finding could help in the treatment of this disease by using anti‐PGF2α drugs.
Thermal treatments and their influence on physicochemical properties of sea cucumbers: a comprehensive review
Authors: Fan Xinru , Ma Yongsheng , Li Meng , Li Ying , Sang Xue , Zhao Qiancheng 
Published: June 2022

SummarySea cucumber is consumed as a traditional, luxury, medicinal and health‐benefit seafood product. Thermal treatment is a necessary step in sea cucumber processing. The quality of cooked sea cucumbers is affected by heating temperature, heating time, heating degree and heating pressure. Furthermore, the storage stability and shelf‐life of mature products are influenced by the processing methods. The loss of nutrients, changes in textural properties and apparent morphology of goods affect consumer preferences. Although some machining techniques, such as high‐pressure and high‐temperature treatments, have been applied to shorten the processing time, negative effects during storage cannot be ignored. In this review, the physical and chemical changes to sea cucumbers during different thermal treatments are compared and summarised, and future work is described. These future efforts are expected to provide suitable thermal treatment and promote innovation in sea cucumber processing technology.
My story of sex, gender, and women's health in a pandemic*
Authors: Klein Sabra L. 
Published: June 2022

AbstractAfter more than 20 years of studying sex differences in viral pathogenesis and immunity to vaccines, the COVID‐19 pandemic provided me with a unique opportunity to raise awareness about biological sex differences. The scientific community and public, alike, embraced the clinical and epidemiological data and supported inquiries into how males are twice as likely to be hospitalized and die from COVID‐19. Immunological changes associated with pregnancy also contribute to worse outcomes from COVID‐19. Collectively, we are finding that inflammation is a critical mediator of worse outcomes for males and pregnant females. The pandemic gave me a platform to discuss and address sex differences on a bigger stage, but two decades of studies working with other viruses prepared me for this moment in history.
The impact of production diseconomies on manufacturer encroachment
Authors: Chen Xiaole , Tang Yanli 
Published: June 2022

AbstractWe consider a supply chain with a manufacturer and a retailer, where the manufacturer is diseconomy of scale regarding production and may encroach into the downstream market. We prove that the production diseconomy changes the traditional wisdom regarding the impact of manufacturer encroachment on supply chain performance. First, we show that the production diseconomy disincentivizes the manufacturer's encroachment. Second, different from the literature that believes retailer can be better off as long as it has a selling cost advantage compared with the manufacturer, we establish the condition where encroachment always hurts the retailer regardless of the selling cost advantage. Third, we find that when the price does not respond sensitively to the quantity, an encroaching manufacturer would increase the wholesale price. Surprisingly, the supply chain's profit still could increase. Finally, we check how the retail competition, imperfect substitution, and price competition affect the corresponding results shown above. We show that the retail competition disincentivizes the manufacturer's encroachment and weakens the whole industry's profit benefit from the encroachment. In contrast, imperfect substitution increases the manufacturer's encroachment incentives and strengthens the industry's profit benefit from the encroachment. In the case of imperfect substitution with quantity competition, the consumers might be worse off after the manufacturer encroaches; otherwise, they benefit from the manufacturer's encroachment.
Effectiveness of prophylactic application of negative pressure wound therapy in stopping surgical site wound problems for closed incisions in breast cancer surgery: A meta‐analysis
Authors: Song Jingyong , Liu Xia , Wu Tingting 
Published: June 2022

AbstractWe performed a meta‐analysis to evaluate the effect of prophylactic application of negative pressure wound therapy in stopping surgical site wound problems for closed incisions in breast cancer surgery. A systematic literature search up to April 2022 was performed and 2223 women with closed incisions in breast cancer surgery at the baseline of the studies; 964 of them were using the prophylactic application of negative pressure wound therapy, and 1259 were using standard dressings. Odds ratio (OR) with 95% confidence intervals (CIs) were calculated to assess the effect of prophylactic application of negative pressure wound therapy in stopping surgical site wound problems for closed incisions in breast cancer surgery using the dichotomous method with a random or fixed‐effect model. The prophylactic application of negative pressure wound therapy women had a significantly lower total wound problems (OR, 0.62; 95% CI, 0.43‐0.90, P = .01), lower surgical site wound infection (OR, 0.59; 95% CI, 0.36‐0.96, P = .03), lower wound dehiscence (OR, 0.54; 95% CI, 0.39‐0.75, P < .001) and lower wound necrosis (OR, 0.44; 95% CI, 0.27‐0.71, P < .001), in women with closed incisions in breast cancer surgery compared with standard dressings. However, prophylactic application of negative pressure wound therapy did not show any significant difference in wound seroma (OR, 0.73; 95% CI, 0.32‐1.65, P = .45), and hematoma (OR, 0.73; 95% CI, 0.33‐1.59, P = .001) compared with standard dressings in women with closed incisions in breast cancer surgery. The prophylactic application of negative pressure wound therapy women had a significantly lower total wound problems, surgical site wound infection, wound dehiscence, and wound necrosis and no significant difference in wound seroma, and hematoma compared with standard dressings in women with closed incisions in breast cancer surgery. The analysis of outcomes should be with caution because of the low sample size of 5 out of 12 studies in the meta‐analysis and a low number of studies in certain comparisons.
Meaningful moments of interaction with people with profound intellectual disabilities: Reflections from direct support staff
Authors: Penninga Wieneke , Nijs Sara L. P. , van Bakel Hedwig J. A. , Embregts Petri J. C. M. 
Published: June 2022

AbstractBackgroundHigh‐quality, affective relationships are built on meaningful moments of interaction, which are challenging for support staff to establish with people with profound intellectual disabilities. Therefore, we explored what makes a moment of interaction meaningful to support staff and what circumstances facilitate meaningful moments of interaction taking place.MethodFive direct support staff took part in unstructured, in‐depth interviews. The interviews were analysed using interpretative phenomenological analysis (IPA). Member checks were also conducted.ResultsSupport staff experienced moments of interaction as meaningful because they felt a connection with a person with profound intellectual disabilities and/or they had the feeling of being meaningful for this person. Staff‐related and contextual circumstances facilitating meaningful moments of interaction to take place were described.ConclusionsMeaningful moments of interaction are highly valued by support staff, who believe these moments are valued by persons with profound intellectual disabilities as well. Implications for daily practice are described.