bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cancer worry among BRCA1/2 pathogenic variant carriers choosing surgery to prevent tubal/ovarian cancer: course over time and associated factors
Authors: van Bommel Majke H. D. , Steenbeek Miranda P. , IntHout Joanna , Hermens Rosella P. M. G. , Hoogerbrugge Nicoline , Harmsen Marline G. , van Doorn Helena C. , Mourits Marian J. E. , van Beurden Marc , Zweemer Ronald P. , Gaarenstroom Katja N. , Slangen Brigitte F. M. , Brood-van Zanten Monique M. A. , Vos M. Caroline , Piek Jurgen M. , van Lonkhuijzen Luc R. C. W. , Apperloo Mirjam J. A. , Coppus Sjors F. P. J. , Prins Judith B. , Custers José A. E. , de Hullu Joanne A. 
Published: January 2022

Abstract
Objective
High cancer risks, as applicable to BRCA1 and BRCA2 pathogenic variant (PV) carriers, can induce significant cancer concerns. We examined the degree of cancer worry and the course of this worry among BRCA1/2-PV carriers undergoing surgery to prevent ovarian cancer, and identified factors associated with high cancer worry.

Methods
Cancer worry was evaluated as part of the multicentre, prospective TUBA-study (NCT02321228) in which BRCA1/2-PV carriers choose either novel risk-reducing salpingectomy with delayed oophorectomy or standard risk-reducing salpingo-oophorectomy. The Cancer Worry Scale was obtained before and 3 and 12 months after surgery. Cancer worry patterns were analysed using latent class growth analysis and associated factors were identified with regression analysis.

Results
Of all 577 BRCA1/2-PV carriers, 320 (57%) had high (≥ 14) cancer worry pre-surgery, and 54% had lower worry 12 months post-surgery than pre-surgery. Based on patterns over time, BRCA1/2-PV carriers could be classified into three groups: persistently low cancer worry (56%), persistently high cancer worry (6%), and fluctuating, mostly declining, cancer worry (37%). Factors associated with persistently high cancer concerns were age below 35 (BRCA1) or 40 (BRCA2), unemployment, previous breast cancer, lower education and a more recent BRCA1/2-PV diagnosis.

Conclusions
Some degree of cancer worry is considered normal, and most BRCA1/2-PV carriers have declining cancer worry after gynaecological risk-reducing surgery. However, a subset of these BRCA1/2-PV carriers has persisting major cancer concerns up to 1 year after surgery. They should be identified and potentially offered additional support.

Clinical trial registration
The TUBA-study is registered at ClinicalTrials.gov since December 11th, 2014. Registration number: NCT02321228.
Rockfall and Rainfall Correlation in the Anaga Nature Reserve in Tenerife (Canary Islands, Spain)
Authors: Leyva Sergio , Cruz-Pérez Noelia , Rodríguez-Martín Jesica , Miklin Luka , Santamarta Juan C. 
Published: January 2022

AbstractRockfalls are frequent and damaging phenomena that occur on steep or vertical slopes, in coastal areas, mountains and along coastal cliff. Water, in different forms, is the most common triggered factor of rockfalls. Consequently, we can consider that precipitation is the most influential factor for slope instabilities and it influences almost all other water parameters. Besides, the specific geology of the Anaga nature reserve in the volcanic island of Tenerife, together with its steep landscape, contributes to the instability of the slopes and frequent rockfalls. Recently, due to climate change and global warming, the annual precipitation/rainfall has declined but the number of heavy storms, associated with intense rainfall and strong winds, events that exceed precipitation thresholds in a brief period has increased which triggers slope movements. This paper describes the analysis of information on rainfall-induced rockfalls in Anaga, Tenerife (Canary Islands), to forecast rock failures of social significance and to improve the capability to respond and emergency decision making. To define reliable thresholds for a certain area, we analized information during the period 2010–2016, reconstructed the rockfall events, and statistically analyzed the historical rainfall conditions that led to landslides. The summary graph correlating precipitation to the probability of occurrence of an event was plotted. Statistical and probability graphs were made with the direct relationship between the number of rockfall events and total rainfall in that period by examining the maximum daily precipitation, not only on the day of the event but up to 3 days before. Hence, the results of this study would serve as a guide for the possible forecasting of rainfall-induced rockfalls, especially for road maintenance services, so that they can be on alert or mobilize the necessary resources in advance depending on the intensity of the expected rainfall.
Review: Horizontal, directionally drilled and radial collector wells
Authors: Houben Georg J. , Collins Sarah , Bakker Mark , Daffner Thomas , Triller Falk , Kacimov Anvar 
Published: January 2022

AbstractHorizontal wells play an often overlooked role in hydrogeology and aquifer remediation but can be an interesting option for many applications. This study reviews the constructional and hydraulic aspects that distinguish them from vertical wells. Flow patterns towards them are much more complicated than those for vertical wells, which makes their mathematical treatment more demanding. However, at some distance, the drawdown fields of both well types become practically identical, allowing simplified models to be used. Due to lower drawdowns, the yield of a horizontal well is usually higher than that of a vertical well, especially in thin aquifers of lower permeability, where they can replace several of the latter. The lower drawdown, which results in lower energy demand and slower ageing, and the centralized construction of horizontal wells can lead to lower operational costs, which can make them an economically feasible option.
Efficacy and safety of trifluridine/tipiracil in older and younger patients with metastatic gastric or gastroesophageal junction cancer: subgroup analysis of a randomized phase 3 study (TAGS)
Authors: Shitara Kohei , Doi Toshihiko , Hosaka Hisashi , Thuss-Patience Peter , Santoro Armando , Longo Federico , Ozyilkan Ozgur , Cicin Irfan , Park David , Zaanan Aziz , Pericay Carles , Özgüroğlu Mustafa , Alsina Maria , Makris Lukas , Benhadji Karim A. , Ilson David H. 
Published: January 2022

Abstract
Background
Trifluridine and tipiracil (FTD/TPI) demonstrated survival benefit vs placebo and manageable safety in previously treated patients with metastatic gastric/gastroesophageal junction cancer (mGC/GEJC) in the randomized, placebo-controlled, phase 3 TAGS study. This subgroup analysis of TAGS examined efficacy/safety outcomes by age.

Methods
In TAGS, patients with mGC/GEJC and ≥ 2 prior therapies were randomized (2:1) to receive FTD/TPI 35 mg/m2 or placebo, plus best supportive care. A preplanned subgroup analysis was performed to evaluate efficacy and safety outcomes in patients aged < 65, ≥ 65, and ≥ 75 years.

Results
Among 507 randomized patients (n = 337 FTD/TPI; n = 170 placebo), 55%, 45%, and 14% were aged < 65, ≥ 65, and ≥ 75 years, respectively. Overall survival hazard ratios for FTD/TPI vs placebo were 0.67 (95% CI 0.51–0.89), 0.73 (95% CI 0.52–1.02), and 0.67 (95% CI 0.33–1.37) in patients aged < 65, ≥ 65, and ≥ 75 years, respectively. Regardless of age, patients receiving FTD/TPI experienced improved progression-free survival and stayed longer on treatment than those receiving placebo. Among FTD/TPI-treated patients, frequencies of any-cause grade ≥ 3 adverse events (AEs) were similar across age subgroups (80% each), although grade ≥ 3 neutropenia was more frequent in older patients [40% (≥ 65 and ≥ 75 years); 29% (< 65 years)]; AE-related discontinuation rates did not increase with age [14% (< 65 years), 12% (≥ 65 years), and 12% (≥ 75 years)].

Conclusions
The results of this subgroup analysis show the efficacy and tolerability of FTD/TPI treatment regardless of age in patients with mGC/GEJC who had received 2 or more prior treatments.
Certification of açaí agroforestry increases the conservation potential of the Amazonian tree flora
Authors: Damasco Gabriel , Anhalt Mandy , Perdiz Ricardo O. , Wittmann Florian , de Assis Rafael L. , Schöngart Jochen , Piedade Maria T. F. , Bacon Christine D. , Antonelli Alexandre , Fine Paul V. A. 
Published: January 2022

AbstractThe harvesting of açaí berries (palm fruits from the genus Euterpe) in Amazonia has increased over the last 20 years due to a high local and global market demand and triggered by their widely acclaimed health benefits as a ‘superfood’. Although such increase represents a financial boom for local communities, unregulated extraction in Amazonia risks negative environmental effects including biodiversity loss through açai intensification and deforestation. Alternatively, the introduction of certified sustainable agroforestry production programs of açaí has been strategically applied to reduce the exploitation of Amazonian forests. Local açaí producers are required to follow principles of defined sustainable management practices, environmental guidelines, and social behaviors, paying specific attention to fair trade and human rights. In this study we investigate whether sustainable agroforestry and certification effectively promotes biodiversity conservation in Amazonia. To address this question, we conducted a forestry inventory in two hectares of long-term certified açai harvesting areas to gain further knowledge on the plant diversity and forest structure in açaí managed forests and to understand the contribution of certification towards sustainable forest management. On average, we found that certified managed forests harbor 50% more tree species than non-certified açaí groves. Trees in certified areas also have significantly higher mean basal area, meaning larger and hence older individuals are more likely to be protected. Certified harvesting sites also harbor dense populations of threatened species as classified by the International Union for Conservation of Nature (e.g. Virola surinamensis, classified as ‘endangered’). Besides increasing the knowledge of plant diversity in açaí managed areas, we present baseline information for monitoring the impact of harvesting activities in natural ecosystems in Amazonia.
Diagnostic and predictive accuracy of anti-mullerian hormone for ovarian function after chemotherapy in premenopausal women with early breast cancer
Authors: Anderson Richard A. , Kelsey Tom W. , Perdrix Anne , Olympios Nathalie , Duhamel Orianne , Lambertini Matteo , Clatot Florian 
Published: January 2022

Abstract
Purpose
Accurate diagnosis and prediction of loss of ovarian function after chemotherapy for premenopausal women with early breast cancer (eBC) is important for future fertility and clinical decisions regarding the need for subsequent adjuvant ovarian suppression. We have investigated the value of anti-mullerian hormone (AMH) as serum biomarker for this.

Methods
AMH was measured in serial blood samples from 206 premenopausal women aged 40–45 years with eBC, before and at intervals after chemotherapy. The diagnostic accuracy of AMH for loss of ovarian function at 30 months after chemotherapy and the predictive value for that of AMH measurement at 6 months were analysed.

Results
Undetectable AMH showed a high diagnostic accuracy for absent ovarian function at 30 months with AUROC 0.89 (96% CI 0.84–0.94, P < 0.0001). PPV of undetectable AMH at 6 months for a menopausal estradiol level at 30 months was 0.77. In multivariate analysis age, pre-treatment AMH and FSH, and taxane treatment were significant predictors, and combined with AMH at 6 months, gave AUROC of 0.90 (95% CI 0.86–0.94), with PPV 0.79 for loss of ovarian function at 30 months. Validation by random forest models with 30% data retained gave similar results.

Conclusions
AMH is a reliable diagnostic test for lack of ovarian function after chemotherapy in women aged 40–45 with eBC. Early analysis of AMH after chemotherapy allows identification of women who will not recover ovarian function with good accuracy. These analyses will help inform treatment decisions regarding adjuvant endocrine therapy in women who were premenopausal before starting chemotherapy.
Strengthening climate-resilient development and transformation in Viet Nam
Authors: Rana Arun , Zhu Qinhan , Detken Annette , Whalley Karina , Castet Christelle 
Published: January 2022

AbstractClimate change is presenting an ongoing and eminent threat to various regions, communities and infrastructure worldwide. In this study, the current and future climate impacts faced by Viet Nam due to Tropical Cyclones (TCs), specifically wind and surge, are evaluated, and different adaptation measures to manage this risk are appraised. The level of wind and storm surge risk was assessed focusing on three categories of assets: residential houses, agriculture, and people. The expected damage to these assets was then evaluated based on their exposure to the hazard under current and future climate scenarios. Physical adaptation measures such as mangroves, sea dykes, and gabions, and financial adaptation measures such as risk transfer via insurance were applied to the expected future risk and evaluated based on a socio-economic cost–benefit analysis. The output will give decision-makers the ability to make more informed decisions, prioritize the most cost-effective adaptation measures and increase physical and financial resilience. The results indicated significant TC exposure in future climate scenarios due to economic development and climate change that almost doubles the current expected damage. Surge-related damage was found to be many times higher than wind damage, and houses had more exposure (value in total) than agriculture on a national scale. The physical adaptation measures are successful in significantly reducing the future wind and especially surge risk and would form a resilient strategy along with risk transfer for managing TC risks in the region.
The association between serum interleukin-1 beta and heparin sulphate in diabetic nephropathy patients
Authors: Jiang Liqiong , Zhou Jianying , Zhang Li , Du Yufeng , Jiang Mingming , Xie Liqian , Ma Zhenni , Chen Fengling 
Published: January 2022

AbstractInflammation is considered an important mechanism in the development of diabetes mellitus (DM) and persists for a long time before the occurrence of diabetic nephropathy (DN). Many studies have demonstrated that a decrease in the endothelial glycocalyx (EG) is negatively correlated with proteinuria. To elucidate whether EG damage induced by inflammasomes in DM patients leads to the occurrence of microalbuminuria (MA) and accelerates the progression of DN, this study screened 300 diagnosed DM patients. Finally, 70 type 2 diabetes patients were invited to participate in this study and were divided into two groups: the T2DM group (patients with normal MA and without diabetic retinopathy, n = 35) and the T2DN group (patients with increased MA and diabetic retinopathy, n = 35). Circulating heparin sulphate (HS, EG biomarkers) and interleukin-1 beta (IL-1β, inflammasome biomarkers) of the patients were measured by ELISA. Laboratory data were measured using routine laboratory methods. Patients in the T2DN group had increased serum HS, increased IL-1β, increased CRP, decreased haemoglobin, and increased neutrophils compared to patients in the T2DM group (all P < 0.05). Increased HS and decreased haemoglobin were independently associated with T2DN patients. ROC curves showed that the AUC of HS for the prediction of T2DN was 0.67 (P < 0.05). The combination of HS and haemoglobin yielded a significant increasement in the AUC (0.75, P < 0.001) with optimal sensitivity (71.2%) and specificity (79%). Furthermore, serum IL-1β was positively correlated with HS and was an independent associated factor of HS in the T2DN group. The relationship between HS and IL-1β was not significant in the T2DM group. Our findings surgessed the inflammasome may be associated with and promote damage to the EG during the disease course of DN that manifests as increased MA.
Descemet membrane endothelial keratoplasty: analysis of clinical outcomes of patients with 8–10 years follow-up
Authors: Weller Julia M. , Kruse Friedrich E. , Tourtas Theofilos 
Published: January 2022

Abstract
Purpose
This study aimed to evaluate the clinical outcomes up to 10 years after Descemet membrane endothelial keratoplasty (DMEK).

Methods
In this retrospective, consecutive, single-center case series the medical files of eyes which have received DMEK between 2009 and 2012 for the treatment of endothelial dysfunction was evaluated regarding follow-up time and clinical outcomes.
Annual examinations of best-corrected visual acuity (BCVA), endothelial cell density (ECD), central corneal thickness (CCT) of 66 eyes which fulfilled the criterion of a minimum of 8 years follow-up were analyzed.

Results
BCVA improved from 0.55 ± 0.37 logMAR (n = 54) to 0.15 ± 0.11 (n = 47) in eyes without ocular comorbidities one year after DMEK (p < 0.001), and remained stable up to 10 years after DMEK. Mean ECD decreased to 744 ± 207 cells/mm2 (n = 39) after 9 years, and to 729 ± 167 cells/mm2 (n = 21) after 10 years, respectively. CCT decreased from 650 ± 67 μm before DMEK to 525 ± 40 μm (n = 56) after 1 year, increasing slowly to 563 ± 40 µm (n = 39) after 9 years, and to 570 ± 42 µm (n = 21) after 10 years, respectively. Graft failure occurred in 4 of 66 eyes after year 8. These 4 eyes required repeat DMEK after 101–127 months.

Conclusion
This study shows the long-term outcomes in a small subset of DMEK grafts. Visual acuity remained stable in spite of slowly increasing corneal thickness and diminishing endothelial cell density during the 10-year period after DMEK.
Beyond pulmonary vein isolation for persistent atrial fibrillation: sequential high-resolution mapping to guide ablation
Authors: Malaczynska-Rajpold Katarzyna , Jarman Julian , Shi Rui , Wright Piers , Wong Tom , Markides Vias 
Published: January 2022

Abstract

Purpose
We aimed to evaluate whether outcomes with ablation in persistent (PsAF) and long-standing persistent (LsPsAF) AF can be improved beyond what can be achieved with pulmonary vein isolation (PVI) alone, using individualized mapping to guide ablation.

Methods
We studied 20 pts (15 M, 68 ± 11y) with PsAF (14) or LsPsAF (6) referred for first-time AF ablation. Following antral PVI, individualized mapping (IM) was performed using a high-density mapping catheter stably and fully deployed for 30 s at each of 23 ± 9 sites per patient. Activation data were reviewed, and an ablation strategy designed to intersect areas of focal and rotational activity. Mean follow-up was 429 ± 131 days. The study population was compared to a matched contemporary control cohort (CC) of 20 consecutive patients undergoing conventional ablation.

Results
Despite the IM group having a higher median comorbidities score, 3.5 vs. 2.5 in the CC group, indicating potentially more complex patients and more advanced substrate, cumulative freedom from AF after a single procedure was achieved in 94% of patients in the IM group vs. 75% in the CC group at 1 year and remained the same in both groups at the conclusion of the study (p = 0.02). There was a similar trend in atrial arrhythmia-free survival between both groups (84% vs. 67% at 1 year) that did not reach statistical significance. The procedure duration was longer in the IM group by a median of 31.5 min (p = 0.004).

Conclusions
Individualized mapping to guide AF ablation appears to achieve significantly greater AF-free survival compared to conventional PVI when applied as a primary ablation treatment. The results of this pilot study need to be confirmed in a larger, randomized trial.
Modelling and condition-based control of a flexible and hybrid disassembly system with manual and autonomous workstations using reinforcement learning
Authors: Wurster Marco , Michel Marius , May Marvin Carl , Kuhnle Andreas , Stricker Nicole , Lanza Gisela 
Published: January 2022

AbstractRemanufacturing includes disassembly and reassembly of used products to save natural resources and reduce emissions. While assembly is widely understood in the field of operations management, disassembly is a rather new problem in production planning and control. The latter faces the challenge of high uncertainty of type, quantity and quality conditions of returned products, leading to high volatility in remanufacturing production systems. Traditionally, disassembly is a manual labor-intensive production step that, thanks to advances in robotics and artificial intelligence, starts to be automated with autonomous workstations. Due to the diverging material flow, the application of production systems with loosely linked stations is particularly suitable and, owing to the risk of condition induced operational failures, the rise of hybrid disassembly systems that combine manual and autonomous workstations can be expected. In contrast to traditional workstations, autonomous workstations can expand their capabilities but suffer from unknown failure rates. For such adverse conditions a condition-based control for hybrid disassembly systems, based on reinforcement learning, alongside a comprehensive modeling approach is presented in this work. The method is applied to a real-world production system. By comparison with a heuristic control approach, the potential of the RL approach can be proven simulatively using two different test cases.
Food Insecurity: Child Care Programs’ Perspectives
Authors: Noerper Tracy E. , Elmore Morgan R. , Hickman Rachel B. , Shea Madison T. 
Published: January 2022

Abstract
Background
Households experiencing "food insecurity" have limited access to food due to a lack of money or resources. Poor nutrition, from food insecurity, can impact physical and cognitive development of children. Study objectives were to document the prevalence of Tennessee child care programs screening for food insecurity, explore differences between programs receiving child and adult care food program (CACFP) funding and those screening for food insecurity, and understand possible burdens food insecurity places on child care families as perceived by child care program directors.

Methods
In this cross-sectional study of licensed Tennessee child care programs, a 10-question survey and four-question follow-up survey were electronically distributed. Analysis included descriptive statistics, a chi-square of programs receiving CACFP funds and screening for food insecurity, and themes analysis of open-ended responses.

Results
The average child care program enrollment (N = 272) was 80.16 with programs serving mostly preschoolers (98.53%) and toddlers (91.91%). Over half (56.99%) of programs reported they received CACFP funding, yet only 9.19% screen for food insecurity. Chi-square analysis found that programs receiving CACFP funds differ significantly on whether they screen households for food insecurity $$\chi$$
χ
2 (1, n = 237) = 16.93, p ≤ 0.001. Themes analysis (n = 41) revealed that many child care program directors do not view food insecurity as a burden for families.

Conclusions
Child care programs receiving CACFP funds are more likely to screen families for food insecurity than programs who do not. Programs indicate a willingness to include food insecurity screening questions on child care paperwork.