bluuebunny/crossref_metadata_2025_split huggingface dataset:
Resveratrol Treatment-induced Nuclear HMGB1 Retention is Critical for
Inducing Host Interferon Responses Against Zika Virus
Authors: Chin Kim-Ling , Zainal Nurhafiza , Sam Sing-Sin , Abu Bakar Sazaly 
Published: November 2022

Background:
Zika virus (ZIKV) infection is a public health concern and currently
there is no specific therapeutic or approved vaccine. Resveratrol (RESV), a natural antiviral
compound, has been shown to possess antiviral properties against ZIKV and other viral infections,
but the mechanisms of action against ZIKV remain unknown.

Objective:
This study aimed to investigate the role of the high mobility group box 1 protein
(HMGB1) in the underlying anti-ZIKV mechanisms of RESV.

Methods:
HMGB1 protein expression and ZIKV replication in both the RESV-treated wildtype
(WT) and HMGB1-knockdown (shHMGB1) Huh7 cells were analyzed using ELISA,
immunofluorescence assay, immunoblot assay, focus-forming assay and qRT-PCR. HMGB1’s
role was explored by evaluating the changes in the type-1 interferon (IFN) response genes using
the qRT-PCR and immunoblot assays.

Results:
The treatment of the ZIKV-infected WT Huh7 cells with RESV significantly
reduced ZIKV titers by >90% (P < 0.001) at 48 and 72 hr pi in a dose-dependent manner and
inhibited ZIKV-induced HMGB1 translocation (P < 0.001), resulting in nuclear HMGB1 accumulation.
Compared to the WT Huh7 cells, shHMGB1 Huh7 cells without RESV treatment
showed a significant increase in the infectious virus titers and RNA with a maximum rise of
74% (P < 0.001) and 65% (P < 0.01), respectively. RESV treatment of the ZIKV-infected WT
Huh7 cells significantly increased the MxA (one of the classical interferon-stimulated genes,
ISGs) and IFN-β levels (P < 0.05). The treatment of the infected shHMGB1 Huh7 cells with
RESV showed a less effective antiviral response (P > 0.05) and did not cause changes in the
expressions of MxA and IFN-β.

Conclusion:
RESV possesses therapeutic activity against ZIKV infection and the mechanism
of action is mainly attributed to HMGB1 nuclear retention, which could upregulate the type-1
IFN and ISGs.
MODEL LATIHAN PERMAINAN KUMITE KATEGORI PRA PEMULA USIA 10-11 TAHUN PADA CABANG OLAHRAGA KARATE
Authors: Susila Gede Hendri Ari , Sukadiyanto Sukadiyanto 
Published: November 2022

Penelitian ini bertujuan menghasilkan model latihan permainan kumite yang dikembangkan menjadi panduan pelatih karate dengan konsep permainan. Penelitian ini dikembangkan dengan mengadaptasi penelitian dan pengembangan pendidikan model Gall, Gall, Borg. Uji coba dengan skala kecil dilakukan terhadap 6 orang kohai dan 18 orang kohai pada skala besar di dojo-dojo DIY. Instrumen yang digunakan untuk mengumpulkan data adalah angket skala nilai validasi, pedoman observasi model latihan permainan, dan pedoman observasi keefektifan model latihan permainan. Hasil penelitian berupa model latihan permainan kumite yang terdiri dari 9 latihan permainan, yaitu: (1) bola gantung zuki, (2) target zuki, (3) bola gantung geri, (4) target geri, (5) kombinasi target zuki dan geri, (6) lingkaran bola gantung zuki, (7) bola gantung geri, (8) lemparan bola gila, dan (9) lempar kontrol bola gila. Model latihan permainan kumite disusun dalam buku pedoman latihan dan CD dengan judul “Bermain Kumite”.Kata kunci: model, latihan, permainan, kumite. MODEL TRAINING GAME PRE NOVICE KUMITE CATEGORY AGES 10-11 YEARS OF AGE IN KARATE SPORTAbstractThis study aims to produce a model exercise game developed into a guide kumite karate coach with the concept of the game. This study was developed by adapting the research and development of educational models Gall, Gall, Borg. With small-scale trials carried out on 6 and 18 kohai kohai on a large scale in the dojo dojo DIY. The instrument used to collect the data was a questionnaire rating scale validation, the model observation exercise game, and the observation model of the effectiveness of exercise games. Results of the research is a model of practice kumite game that consists of 9 exercise games, namely: (1) balls hanging zuki, (2) the target zuki, (3) balls hanging geri, (4) the target geri, (5) a combination of the target and the zuki geri, (6) circle hanging balls zuki, (7) balls hanging geri, (8) throws the ball crazy, and (9) controls the ball throwing crazy. Models are arranged kumite practice games in training manual and a CD with the title "Playing Kumite".Keywords: models, training, game, kumite.
Pengaruh latihan weight training, pliometrik, dan panjang tungkai terhadap keterampilan tendangan Sabit
Authors: Mahardhika Nanda Alfian , Sutapa Panggung 
Published: November 2022

Penelitian untuk mengungkapkan: (1) perbedaan pengaruh weight training dan pliometrik, (2) perbedaan pengaruh panjang dan pendeknya tungkai, dan (3) interaksi latihan weight training, pliometrik dan panjang tungkai terhadap keterampilan tendangan sabit. Metode penelitian eksperimen faktorial 2x2. Populasi berjumlah 37 pesilat, sampel 20 pesilat. Instrumen tes keterampilan tendangan sabit dari Johansyah Lubis. Teknik analisis data ANOVA dua jalur α = 0,05. Hasil menunjukkan: (1) Ada perbedaan pengaruh weight training, pliometrik, dan panjang tungkai terhadap keterampilan tendangan sabit. (2) Ada perbedaan pengaruh panjang dan pendeknya tungkai terhadap keterampilan tendangan sabit. (3) Ada interaksi weight training, pliometrik, dan panjang tungkai terhadap keterampilan tendangan sabit. Terbukti dari nilai p 0,05. The effect of weight training, plyometrics, long legs skills on the kick of Sabit Abstract: Research to disclose: (1) effect differences in the influence of weight training and plyometrics, (2) effect differences in the long legs and short legs, and (3) the interaction of exercise weight training, plyometrics, and leg length on skills of kick sabit. Research is an experiment with a 2 x 2 factorial design. The population of 37 pesilat, sample 20 pesilat. The instruments of a kick use skills kick Sabit test from Johansyah Lubis. Data analysis techniques ANOVA two lanes α = 0.05. Results showed: (1) There is a different effect of weight training, plyometrics, leg length skills on the kick of sabit. (2) There is a different effect of long legs and short legs on the skills of kick sabit. (3) There is an interaction of weight training, plyometrics and leg length on skills of kick sabit.
Automated Digital Interventions and Smoking Cessation: Systematic Review and Meta-analysis Relating Efficiency to a Psychological Theory of Intervention Perspective
Authors: Sha Leihao , Yang Xia , Deng Renhao , Wang Wen , Tao YuJie , Cao HaiLing , Ma Qianshu , Wang Hao , Nie Yirou , Leng Siqi , Lv Qiuyue , Li Xiaojing , Wang Huiyao , Meng Yajing , Xu Jiajun , Greenshaw Andrew J , Li Tao , Guo Wan-jun 
Published: November 2022

Background
Smoking remains a highly significant preventable global public health problem. In this context, digital interventions offer great advantages in terms of a lack of biological side effects, possibility of automatic delivery, and consequent human resource savings relative to traditional interventions. Such interventions have been studied in randomized controlled trials (RCTs) but have not been systematically reviewed with the inclusion of text-based and multiplatform-based interventions. In addition, this area has not been evaluated from the perspective of the psychological theoretical basis of intervention.

Objective
The aim of this paper is to assess the efficiency of digital interventions in RCT studies of smoking cessation and to evaluate the effectiveness of the strategies used for digital interventions.

Methods
An electronic search of RCTs was conducted using PubMed, Embase, and the Cochrane Library by June 30, 2021. Eligible studies had to compare automated digital intervention (ADI) to the use of a self-help guideline or no intervention. Participants were current smokers (aged 16 years or older). As the main outcome, abstinence after endpoint was extracted from the studies. Systematic review and meta-analysis were conducted to assess the efficiency of ADIs. Metaregressions were conducted to assess the relationship between intervention theory and effectiveness.

Results
A total of 19 trials (15,472 participants) were included in the analysis. The overall abstinence rate (95% CI) at the endpoint was 17.8% (17.0-18.7). The overall risk ratio of the intervention group compared to the controls at the endpoint was 17.8% (17.0-18.7). Cochrane risk-of-bias tool for randomized trials (ROB 2) suggested that most of the studies had a low risk of bias (56.3%). Psychological theory–related constructs or predictors, which refer to other theory-based concepts (rather than only behavioral theory) such as craving or anxiety, are associated with effectiveness.

Conclusions
This study found that ADI had a clear positive effect compared to self-help guidelines or to no intervention, and effectiveness was associated with theory-related constructs or predictors. ADIs should be promoted by policy makers and clinical practitioners to address the huge gap between the need for smoking cessation and availability of traditional treatment resources. Possible increases in ADI efficiency may be achieved by optimally integrating psychotherapeutic theories and techniques.

Trial Registration
PROSPERO CRD42021256593; https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=256593
Global Principles of Sustainable Tourism Development Ecological, Economic and Cultural
Authors: I Nyoman Nurjaya  
Published: November 2022

Indonesia is known as a country that has the beauty of the natural panorama of the sea and land and also invaluable cultural resources for the development of national tourism, in order to realizing the welfare and prosperity of the people as mandated by the1945 Constitution of the Republic of Indonesia. This research focus on discuss Global Principles of Sustainable Tourism Development and Sustainable Tourism Development Policy in Bali Province and to analyze the management of tourism destination in KSPN Kintamani-Lake Batur. This research is a normative legal research. The data used are primary and secondary data. The result explaine that the main economic sector in Bali, on the one hand, tourism performance is required to reduce the negative impact of tourism development. Nationally, with the enactment of Law Number 10 of 2009 concerning Tourism and Government Regulation Number 50 of 2011 concerning the National Tourism Development Master Plan (RIPKN), the Bali Provincial Government is required to prepare a Regional Tourism Development Master Plan (RIPKD) as stated in Bali Provincial Regulation No. 10 of 2015 concerning the Bali Provincial Tourism Development Master Plan for 2015-2029, which contains visions, directions, and plans that direct the development of tourist areas in Bali.
PEMBERDAYAAN KELOMPOK IBU PKK DI DESA RENON DALAM PENGELOLAAN DIIT DAN PEMANTAU MINUM OBAT PASIEN DIABETES
Authors: Santosa Agus , Widari D A P Niti , Setiawan K Irwan , Hendrayani Vemi , Masyeni Sri 
Published: November 2022

Penyakit diabetes mellitus merupakan penyakit metabolik yang ditandai dengan peningkatan kadar gula darah yang diakibatkan oleh berbagai faktor seperti kerusakan sel beta pancreas atau penyakit autoimun yang menimbulkan kerusakan pancreas. Kadar gula darah yang berkepanjangan akan memicu kerusakan sel endotel yang dapat mengakibatkan komplikasi seperti penyakit ginjal kronis, penyakit jantung dan stroke yang akan memicu permasalahan yang lebih kompleks. Salah satu cara untuk memperlambat munculnya komplikasi diabetes adalah melalui pengontrolan gula darah melalui pengelolaan diit diabetes serta mengonsumsi obat secara rutin. Dukungan keluarga terdekat sangat dibutuhkan dalam membantu penderita diabetes dalam kontrol gula darah. Kegiatan pengabdian ini bertujuan untuk memberdayakan mitra, yaitu kelompok ibu di desa Renon supaya bisa berperan sebagai pengelola diit dan pemantau minum obat pasien diabetes. Kegiatan diawali dengan rapat koordinasi, focus group discussion untuk menemukan permasalahan prioritas mitra. Solusi untuk mitra adalah pemberdayaan kelompok ibu tersebut yang diawali dengan pre-tes untuk mengukur tingkat pengetahuan ibu mengenai diabetes, penyampaian materi, praktek mengatur diit diabetes serta mengawasi minum obat. Pemaparan materi dilakukan melalui peragaan pamphlet, poster serta video dan diakhiri dengan post-test. Out-put kegiatan diukur dari peningkatan pengetahuan mitra dari hasil pre dan post-test dimana ditemukan peningkatan pengetahuan mitra sebanyak 75%. Outcome akan diukur dari tercapainya kontrol gula darah pasien dan terhambatnya komplikasi diabetes.
PENGARUH HARGA, WORD OF MOUTH DAN KUALITAS PELAYANAN TERHADAP KEPUTUSAN PEMBELIAN PRODUK PADA CV. LAGAS JAYA BADUNG
Authors: Mahendra I Komang Arthur , Pertama I Gde Agung Wira , Idawati Ida Ayu Agung 
Published: November 2022

Keputusan pembelian adalah sebuah tindakan yang diambil konsumen dalam memilih satu produk dari beberapa alternatif pilihan yang ada. Penelitian ini berjudul “Pengaruh Harga, Word of Mouth dan Kualitas Pelayanan Terhadap Keputusan Pembelian Produk Pada CV. Lagas Jaya Badung”. Tujuan penelitian ini adalah untuk mengetahui dan menganalisis pengaruh harga word of mouth dan kualitas pelayanan terhadap keputusan pembelian produk pada CV. Lagas Jaya Badung baik secara simultan dan parsial. Data penelitian dikumpulkan menggunakan penyebaran kuesioner dengan sampel berjumlah 87 responden. Metode penelitian menggunakan analisis kuantitatif dengan teknik analisis regresi linier berganda, uji hipotesis (uji F dan uji t). Berdasarkan hasil uji F, harga, word of mouth dan kualitas pelayanan secara simultan berpengaruh signifikan terhadap keputusan pembelian produk pada CV. Lagas Jaya Badung. Berdasarkan hasil analisis regresi linier berganda, pada uji t ditemukan bahwa harga, word of mouth dan kualitas pelayanan secara parsial berpengaruh positif & signifikan terhadap keputusan pembelian produk pada CV. Lagas Jaya Badung.
KEPUASAN MASYARAKAT ACEH BARAT TERHADAP PELAYANAN PEMBUATAN JKN PADA BPJS KESEHATAN CABANG MEULABOH
Authors: Zulfa Ummul , Anas Alfian 
Published: November 2022

Penelitian ini bertujuan untuk menganalisis apakah masyarakat Aceh Barat puas dengan pelayanan dalam pembuatan JKN yang diberikan oleh BPSJ Kesehatan Cabang Meulaboh, dan apakah pelayanan yang diberikan oleh BPJS Kesehatan sudah sesuai dengan yang diharapkan masyarakat. Penelitian ini menggunakan deskriptif kualitatif. Populasi dalam penelitian ini adalah seluruh peserta pembuatan kartu JKN dengan jumlah sampel 100 orang. Hal ini terlihat dari skor tertinggi pada kesesuaian pelayanan dengan yang diharapkan berada pada kategori baik dengan nilai rata-rata 2,97. Kemudian dengan nilai rata-rata tertinggi kedua dimana reliability dan assurance adalah 2,96. Ketiga, nilai terendah pada tangible dan empati sebesar 2,92. Nilai tersebut dapat menunjukkan bahwa kepuasan masyarakat Aceh Barat terhadap BPJS Kesehatan Cabang Meulaboh adalah baik.
“(Pseudo)Cavities inside the heart: what may they unfold?”
Authors: Campinas Andreia , Cabral Sofia , Frias André Dias de , Alexandre André , Couto David Sá , Rodrigues Patrícia , Gomes Catarina , Caiado Luísa , Torres Severo 
Published: November 2022

Subvalvular aortic stenosis manifesting as a subaortic membrane
predisposes to bacterial endocarditis, which typically affects the
aortic valve or, less frequently, the left ventricular outflow tract. We
present the case of a 60-year-old woman expressing an odd form of a
subvalvular aortic membrane in conjunction with a left Valsalva sinus
pseudoaneurysm as a result of an endocarditis complication.
Long-term exposure to ambient PM2.5 and its components associated with diabetes mellitus: Evidence from a large population-based cohort from China
Authors: Li Sicheng , Guo Bing , Jiang Ye , Wang Xing , Chen Lin , Wang Xue , Chen Ting , Yang La , Silang Yangzong , Hong Feng , Yin Jianzhong , Lin Hualiang , Zhao Xing , (CMEC) China Multi-Ethnic Cohort 
Published: November 2022

<p> </p>
<p><strong>Objective </strong>Association between PM2.5 components and diabetes mellitus (DM) remains unclear. We therefore aimed to investigate the associations of long-term exposure to PM2.5 components with DM.</p>
<p><strong>Research Design and Methods</strong> This study included 69,210 adults with no history of diabetes from a large-scale epidemiologic survey in Southwest China from 2018-2019. The annual average concentrations of PM2.5 and its components were estimated using satellite remote sensing and chemical transport modeling. DM was identified as fasting plasma glucose ≥7.0 mmol/L (126 mg/dL) or hemoglobin A1c ≥48 mmol/mol (6.5%). The logistic regression model and weighted quantile sum method were used to estimate the associations of single and joint exposure to PM2.5 and its components with DM, respectively.</p>
<p><strong>Results</strong> Per-standard deviation increases in the three-year average concentrations of PM2.5 (OR [odds ratio] =1.08, 95% CI [confidence interval], 1.01–1.15), black carbon (BC, 1.07, 1.01–1.15), ammonium (1.07, 1.00–1.14), nitrate (1.08, 1.01–1.16), organic matter (OM, 1.09, 1.02–1.16), and soil particles (SOIL, 1.09, 1.02–1.17) were positively associated with DM. The associations were stronger in those older than 65 years. Joint exposure to PM2.5 and its components was positively associated with DM (1.04, 1.01–1.07). The estimated weight of OM was the largest among PM2.5 and its components.</p>
<p><strong>Conclusions</strong> Long-term exposure to BC, nitrate, ammonium, OM, and SOIL is positively associated with DM. Moreover, OM might be the most responsible for the relationship between PM2.5 and DM. This study adds to the evidence of a PM2.5–DM association and suggests controlling sources of OM to curb the burden of PM2.5-related DM. </p>
MENINGKATKAN IMTAK DAN HASIL BELAJAR PAI BUDI PEKERTI DENGAN METODE PROBELAM BASED LEARNING PESERTA DIDIK KELAS XII IPA 5 SEMESTER GANJIL SMA NEGERI 3 METRO
Authors: Urman Yuliana Rusdi 
Published: November 2022

Inti pembelajaran Agama Islam dan Budi Pekerti adalah peserta didik kelas XII IPA 5 memiliki kemampuan untuk membaca, menulis ,menyimak, berbicara,memngkomunikasikan khususnya isi kandungan dalam ayat-ayat Alqur’an. Tujuan penelitian untuk mendeskripsikan pembelajaran PAI BK dan metode Problem Based Learning bagi peserta didik kelas XII IPA 5 SMA Negeri 3 Metro. Metode penelitian menggunakan teknik tes - teknik non tes serta obervasi, dokumentasi, dan wawancara. Hasil penelitian dengan metode Problem Based Learning, pembelajaran Imtaq peserta didik kelas XII IPA 5 SMA Negeri 3 Metro hal ini dapat dijelaskan sebagai berikut: 1) membaca Al Qur’an, 2) keimanan/aqidah, 3) akhlah/muamalat, 4 ) fiqih/ibadah, dan 5) menghafal QS. Luqman/QS. Al Baqarah yang digunakan. Proses pembelajaran Imtaq dengan metode Problem Based Learning dari prasiklus, siklus I, siklus II, serta ketekunan hasil belajar meningkat. Dari hasil prasiklus rata-rata 46%, siklus I menjadi 66%. Siklus II menjadi 75%, siklus III meningkat menjadi 80% peserta didik kelas XII IPA 5 SMA Negeri 3 Metro tahun pelajaran 2018/2019. Ketuntasan belajar pada prasiklus masih 0, pada siklus I terdapat 10 orang ( 31,25% ), siklus II 19 orang (59,37% )dan siklus III 32 orang (100%).
'How I have ever loved the life removed': re-interpreting the convention of disguise in Shakespeare's measure for measure
Authors: Dale Inga , Dale James 
Published: November 2022

The paper focuses on the design of Duke Vincentio from Shakespeare's Measure for Measure, interpreted as a highly ambiguous example of the traditional 'ruler in disguise,' set within New Historicism's methodological framework and the theory of Renaissance self-fashioning proposed by Stephen Greenblatt. Although not a treatise on disguise theory, Greenblatt's Renaissance Self-Fashioning (1980) develops analyses appearing highly relevant to the study of disguise in the early modern social and literary context. This is due to the key significance of disguise in his reading of Renaissance culture, typified by, argues Greenblatt, the predominance of rhetoric and ever-present theatricality. Applying Greenblatt's analyses to Shakespeare's Duke, I will show how self-fashioning governs the character's self-identity, resulting in an emergence of behaviours into the character's discourse, indicating a great psychological conflict.
Changing Landscapes but Ingrained Power Relations? The Green Promise of the COVID-19 Pandemic, the (Un)sustainability of the Fashion Industry, and the Central-Eastern European Production Background
Authors: Dobos Emese 
Published: November 2022

AbstractThe COVID-19 pandemic turned the spotlight on the inequalities and the vulnerability of the global supply chains. It showed the serious dependency and the asymmetrical power relations among the stakeholders of the fashion industry. The relocation tendencies – as fashion brands are trying to break up with Asia and move production closer – have already started, and the pandemic can give a boost to it. The Central-Eastern European region can be a possible destination. The shorter supply chains are not just a tool for resilience but are told to serve sustainability as well. My hypothesis is that even though the geography of fashion industry is changing, power relations are not, and the crisis caused by the coronavirus pandemic has even increased dependency among the different players. Power relations are important among the region’s production and the clients if relocation is to work out, as there is need for inclusive, fair, and decent employment, which is rarely guaranteed by fashion brands. Without it, sustainability cannot be achieved. In this paper, I focus on the examination of socio-economic processes in contemporary fashion such as the relocation tendencies and the power relations among the stakeholders, mainly fashion brands and production companies as subcontractors of the fashion industry. Especially, I examine profit and risk as factors within the relations. The critical essay uses literature review and document analysis to investigate a possible change in the current role of power relations and to examine the hypothesis.
The Per(ver)formative Aspects of Pandemic Fashion Performances: Moschino’s Deconstructive Marionettes
Authors: Egri Petra 
Published: November 2022

Abstract
It is said that due to the social and economic effects of the recent pandemic, fashion has been caught in a destructive position. One aspect is the material change of the fashion objects and the strong pre-eminence of the so-called “stay-at-home collections” against the earlier dominance of the ready-to-wear and haute couture garments intended for social events. An important feature of recent fashion changes is their reliance on current pandemic rules and the related political decisions. In my presentation, I will focus on an interesting example of these pandemic changes: Moschino’s 2021 Spring/Summer Collection. Moschino’s “Marionette Performance” is a perfect example for infelicitous performativity where the show is created in a per(ver)formative (in the Derridean sense) act in the catwalk space. I intend to show that performativity is broken at every step of the show. In this spring collection, not only are the mannequins substituted by dolls but the viewers – some are well known (e.g. Anna Wintour) – are also transformed into marionettes by Jeremy Scott. With a self-ironic gesture, anyone of us from the possible audience can be changed into a puppet. To analyse the performative character of the show, I use deconstructive approaches and ideas. I wish to emphasize the interweaving performative dimensions that, in a sense, preclude each other with the help of Paul de Man’s interpretation of Kleist’s Über das Marionettentheater. I want to point out the mechanical, meaningless materiality appearing in the marionettes’ movements on Moschino’s special catwalk. My lecture argues that in the movements of the marionettes the possibility of the clear manifestation of performativity becomes uncertain.