bluuebunny/crossref_metadata_2025_split huggingface dataset:
BRCAShare—Assessment of an animated digital message for intrafamilial communication of pathogenic variant positive test results: A feasibility study
Authors: Aeilts Amber M. , Carpenter Kristen M. , Hovick Shelly R. , Byrne Lindsey , Shoben Abigail B. , Senter Leigha 
Published: November 2022

AbstractWhile genetic testing for hereditary breast and ovarian cancer syndrome (HBOC) is well‐established in the field of medicine, family members' uptake of cascade genetic testing for known familial pathogenic variants remains low. Probands often become responsible for initiating familial communication about their testing results, and barriers to communication may include difficulty in conveying information to relatives and a lack of communication resources for probands' use. In this study, we tested a two‐minute animated digital message (ADM) intervention guided by the Health Belief Model (HBM) in an unselected sample to determine hypothetical individual perceptions of susceptibility and severity and behavioral intention to act on the information provided in the ADM. We recruited genetic testing naïve adults from the United States with no personal history of cancer through Amazon Mechanical Turk to participate in this study. Participants were presented a hypothetical scenario describing a relative's recent HBOC diagnosis, viewed the ADM, and answered a questionnaire assessing participants' perception of the HBM constructs in relation to the hypothetical scenario and participants' intentions to pursue cascade genetic testing, talk to a healthcare professional, or talk to family members after ADM viewing. Participants (n = 373) largely perceived HBOC as serious and believed that they could benefit from the information provided by genetic testing; 76% hypothetically intended to pursue genetic testing at a cost of $100 or less, and 90% intended to either pursue testing or talk to a healthcare provider or family members. This feasibility study in an unaffected population could mimic the experience of distant/less‐engaged relatives in HBOC families after receiving unexpected information about cascade genetic testing. Most participants demonstrated behavioral intention toward cascade testing, at a rate higher than literature would suggest is typical in high‐risk families, indicating that a theory‐supported, simple to use intervention may be useful in clinical practice.
Synthesis, characterization and antibacterial evaluation of N‐(2‐Morpholinoethyl)‐3‐phenylquinoxalin‐2‐amine derivatives
Authors: Shruthi Jeegundipattana B. , Kiran Kuppalli R. , Divyashree Shivakumar , Sreenivasa Marikunte Y. , Sadashiva Maralinganadoddi P. 
Published: November 2022

AbstractA series of substituted N‐(2‐Morpholinoethyl)‐3‐phenylquinoxalin‐2‐amines (5a–j) (5ab, 5ac) were synthesized in good yield and characterized for their structural confirmation. The pure quinoxaline products were screened for their in‐vitro antibacterial activity against Salmonella paratyphi, a well‐known food borne pathogen. The preliminary results revealed that among the series, compounds 5a, 5c, 5d, 5e, 5f, 5h, 5ab and 5ac bearing bromo, fluoro, methoxy, methyl groups at para position on phenyl ring which inturn substituted at third position of quinoxaline and methyl, benzoyl groups at sixth position on the quinoxaline were emerged as potential candidates by displaying antisalmonella activity. Among the potential candidates, compounds 5c, 5e, 5f and 5ac were effective against Salmonella whereas compounds 5a, 5f and 5ac effectively inhibited the biofilm formation of Salmonella.
Clinical validation of a semi‐automated segmentation algorithm for target volume definition on planning CT and CBCT in stereotactic body radiotherapy (SBRT) for peripheral lung lesions
Authors: Mohamed Ahmed Allam , Risse Kathrin , Schmitz Laura , Schlenter Marsha , Chughtai Ahmed , Ivanciu Maria , Eble Michael J. 
Published: November 2022

AbstractIntroductionStereotactic body radiotherapy (SBRT) is an ablative method for lung malignancies. Here, the definition of the gross target volume (GTV) is subject to interobserver variation. In this study, we aimed to evaluate the interobserver variability during SBRT and its dosimetric impact, as well as to introduce a semi‐automated delineation tool for both planning computer tomography (P‐CT) and cone beam CT (CBCT) to help to standardise GTV delineation and adaptive volume‐change registration.MethodsThe interobserver variation of GTV manual contours from five physicians was analysed in 15 patients after lung SBRT on free breathing (FB) P‐CT (n = 15) and CBCT (n = 90) before and after each fraction. The dosimetric impact from interobserver variations of GTV based on the original treatment plan was analysed. Next, the accuracy of an in‐house easy‐to‐use semi‐automated‐segmentation algorithm for pulmonary lesions was compared with gold standard contours in FB P‐CT and CBCT, as well as 4D P‐CT of additional 10 patients.ResultsThe interobserver variability in manual contours resulted in violations of dose coverage of the planning target volume (PTV), which, in turn, resulted in compromised tumour control probability in contours from four physicians. The validation of the semi‐automated delineation algorithm using thorax phantom led to a highly reliable accuracy in defining GTVs. Comparing the unsupervised auto‐contours with the gold standard delineation revealed high equal high concordance for FB P‐CT, 4D P‐CT and CBCT, with a DSC of 0.83, 0.76 and 0.8, respectively. The supervised use of the semi‐automated delineation tool improved its accuracy, with DSCs of 0.86, 0.86 and 0.8 for FB P‐CT, 4D P‐CT and CBCT, respectively. The use of the algorithm was associated with a significantly shorter working time. The semi‐automated delineation tool can accurately register volume changes in CBCTs.ConclusionThe segmentation algorithm provides a reliable, standardised and time‐saving alternative for manual delineation in lung SBRT in P‐CT and CBCT.
Dengue surge in Pakistan amidst the torrential rains: The threat of a potential outbreak
Authors: Shoaib Aqsa , Salim Najwa , Waseem Summaiyya 
Published: November 2022

AbstractWith 390 million infections occurring globally and the infection putting half of the world's population at risk, dengue is an illness with potential, life‐threatening manifestations such as plasma leakage and fluid retention, severe bleeding, and organ impairment. This disease is already lurking in the various regions of Pakistan, which was recently ravaged by decades’ worst flood. With mosquitoes being its eminent transmission source, it is coherent that a country with massive flooding, accumulation of stagnant water, and lack of adequate drainage systems can lead to a dengue outbreak. Pakistan, a low‐middle‐income country, is still recuperating from the aftershocks of the pandemic, a recent cholera outbreak, and the massive economic destruction they caused, especially in the healthcare sector. Concerningly, the World Health Organization has already issued a “second catastrophe” warning for Pakistan in the aftermath of the fatal floods which have caused the destruction of hundreds of health facilities while physicians and medical workers on the ground scramble to combat outbreaks of waterborne and other illnesses. If the spread of dengue isn't contained immediately, it will destroy the healthcare systems across the country and result in massive fatalities. To avoid tragic consequences, the government and concerned authorities must devise plans to launch public health programs aimed at boosting knowledge of the disease, its symptoms, transmission, prevention, and control. In this commentary, we discuss the current spike of dengue virus, epidemiology, transmission patterns, and preventative efforts in the aftermath of Pakistan's disastrous floods.
Molecular characterization of circulating Dengue virus 2 during an outbreak in Northern Senegal's Saint‐Louis region in 2018
Authors: Dieng Idrissa , Ndiaye Mignane , Ndione Marie Henriette Dior , Sankhe Safietou , Diagne Moussa Moïse , Sagne Samba Niang , Gaye Aboubacry , Balde Diamilatou , Barry Aliou , Fall Gamou , Sall Amadou Alpha , Loucoubar Cheikh , Faye Oumar , Faye Ousmane 
Published: November 2022

AbstractGlobally, 390 million people are at risk of dengue infection and over the past 50 years, the virus incidence increased thirty‐fold. In Senegal, an unprecedented occurrence of outbreaks and sporadic cases have been noticed since 2017. In October 2018, an outbreak of Dengue virus 2 (DENV‐2) was reported in the north of Senegal affecting multiple areas including Saint‐Louis, Richard Toll, and Rosso which are located at the border with Mauritania. Of these 173 blood specimen samples collected from patients, 27 were positive for dengue by quantitative reverse transcription PCR (qRT‐PCR), and eight were serologically confirmed to be positive for DENV immunoglobulin M (IgM). Serotyping using qRT‐PCR reveals that isolates were positive for DENV‐2. A subset of DENV‐2 positive samples was selected and subjected to whole‐genome sequencing followed by phylogenetic analysis. Analysis of six nearly complete genome sequences revealed that the isolates belong to the cosmopolitan genotype and are closely related to the Mauritanian strains detected between 2017 and 2018 and those detected in many West African countries such as Burkina Faso or Cote d'Ivoire. Our results suggest a transboundary circulation of the DENV‐2 cosmopolitan genotype between Senegal and Mauritania and call for a need for coordinated surveillance of arboviruses between these two countries. Interestingly, a high level of homology between West African isolates highlights endemicity and calls for the set‐up of subregional viral genomic surveillance which will lead to a better understanding of viral dynamics, transmission, and spread across Africa.
Area under the curve‐optimized synthesis of prediction models from a meta‐analytical perspective
Authors: Yoneoka Daisuke , Omae Katsuhiro , Henmi Masayuki , Eguchi Shinto 
Published: November 2022

AbstractThe number of clinical prediction models sharing the same prediction task has increased in the medical literature. However, evidence synthesis methodologies that use the results of these prediction models have not been sufficiently studied, particularly in the context of meta‐analysis settings where only summary statistics are available. In particular, we consider the following situation: we want to predict an outcome Y, that is not included in our current data, while the covariate data are fully available. In addition, the summary statistics from prior studies, which share the same prediction task (i.e., the prediction of Y), are available. This study introduces a new method for synthesizing the summary results of binary prediction models reported in the prior studies using a linear predictor under a distributional assumption between the current and prior studies. The method provides an integrated predictor combining all predictors reported in the prior studies with weights. The vector of the weights is designed to achieve the hypothetical improvement of area under the receiver operating characteristic curve (AUC) on the current available data under a practical situation where there are different sets of covariates in the prior studies. We observe a counterintuitive aspect in typical situations where a part of weight components in the proposed method becomes negative. It implies that flipping the sign of the prediction results reported in each individual study would improve the overall prediction performance. Finally, numerical and real‐world data analysis were conducted and showed that our method outperformed conventional methods in terms of AUC.
The Treatment Effect of Non‐Surgical Ear Molding Correction in Children with Mild Cryptotia Deformity
Authors: Xu Huijuan , Ding Shaoguang , Yang Haitao , Qin Litao , Xie Cuncun , Jia Xiaodong , Zang Yanzi , Yao Wenfeng , Li Qian , Wang Guangke , Liu Hongjian 
Published: November 2022

ObjectiveTo investigate the treatment effect of non‐surgical ear molding correction in children with mild cryptotia deformity.Methods51 cases were collected from 2016 to 2021. They were divided into four groups (6 months–1 year group, 1–3 years group, 3–6 years group, and ≥6 years group). The effective rate, recurrence rate, complication rate, and treatment duration of non‐surgical ear molding correction were analyzed among the four groups.Results3 months after the end of corrective treatment, the overall effective rate was 92.2% (47/51), the overall recurrence rate was 7.8% (4/51), and there was statistical significance among the four groups (p = 0.001). The overall complication rate was 2.0% (1/51), and there was no statistical significance among the four groups (p = 1.000). There was statistical significance in the treatment duration among the four groups (p < 0.001), and the mean duration of treatment was positively correlated with the age at treatment (p < 0.001, R = 0.614).ConclusionsWe first propose and recommend that the treatment time window for non‐surgical ear molding correction be maximally extended to 6 years old in children with mild cryptotia deformity. There is a high success rate of non‐surgical ear molding correction in children with mild cryptotia deformity. The complication rate is low. There is a positive correlation between the mean treatment duration and the age at treatment, and the treatment duration increases with the growth of months.Level of Evidence4 Laryngoscope, 133:2122–2128, 2023
The relationship between round window and ear canal Cochlear microphonic
Authors: Yu Yongqiang , Liu Junping , Antisdel Jastin , Liu Changming , Sappington Joshua , Wang Xiaobin , Gao Yunge , Peng Yanguo , Wang Hui , Lin Zhonghao , Ruan Hongguang , Wang Ruiying , Lin Shuwu , Zhang Ming 
Published: November 2022

AbstractHypothesisCochlear microphonic recorded at ear canal (CM‐EC) can be a substitute for the one recorded at round window (CM‐RW).BackgroundAlmost all clinics do not measure tone‐burst evoked CM due to technical difficulty although it can provide more information than click evoked CM. Moreover, clinicians like the CM‐EC more than that measured at CM‐RW because CM‐EC is non‐invasive. There is difference between CM‐RW and CM‐EC, for example, CM‐EC is less prominent than CM‐RW, therefore, studying tone‐burst evoked CM‐EC and its relationship with CM‐RW are highly significant and can promote the clinical application of CM‐EC.MethodNine guinea pigs were randomly allocated into three groups, group 1 was not exposed to noise, called normal control. group 2 and group 3 were exposed to the low‐ (0.5–2 kHz) and high‐frequency band‐noise (6–8 kHz) at 120 dB SPL for 1 h, respectively. It was difficulty to record low‐frequency CM due to severe environmental interruption, in current study the recording technology of tone‐burst evoked CM was optimized so that tone‐burst evoked CM was measured across full speech frequency (0.5–8 kHz) in the presence of normal hearing and noise induced hearing loss (NIHL).ResultsCM‐RW and CM‐EC were successfully recorded across speech frequency. Significant reduction in CM amplitude was observed at 0.5 and 2 kHz in group 2, at 6 and 8 kHz in group 3 as compared to group 1, p < .05, indicating that CM amplitude was sensitive to band‐noise exposure. Significant correlation between CM‐RW and CM‐EC was also verified, p < .05.ConclusionCM‐EC is a useful objective test for evaluation of hearing function; the result of current study supports the clinical application of non‐invasive CM‐EC.
ENKUR recruits FBXW7 to ubiquitinate and degrade MYH9 and further suppress MYH9‐induced deubiquitination of β‐catenin to block gastric cancer metastasis
Authors: Liu Jiahao , Liu Zhan , Yan Weiwei , Yang Huiling , Fang Shiyi , Deng Shuting , Wen Yinghao , Shen Peng , Li Yonghao , Hou Rentao , Liu Xiong , Huang Tao , Li Rong , Zheng Dayong , Liu Zhen , Fang Weiyi 
Published: November 2022

AbstractEnkurin, TRPC Channel Interacting Protein (ENKUR) was shown as a suppressor in some tumors. However, the biological role of ENKUR on gastric cancer (GC) and its related molecular mechanisms is not clear. Here, we first observed that ENKUR significantly inhibited cell migration, invasion, and metastasis in GC. The molecular basis showed β‐catenin‐mediated epithelial‐mesenchymal transition (EMT) signaling was inactivated in ENKUR‐overexpressing GC cells. In addition, ENKUR knockdown markedly restored cell migration and invasion. Subsequently, ENKUR bound to MYH9 and decreased its protein expression by recruiting E3 ubiquitin ligase F‐Box And WD Repeat Domain Containing 7 (FBXW7) to form an ubiquitinated degradation complex. The downregulated Myosin Heavy Chain 9 (MYH9) protein weakened the recruitment of the deubiquitinase USP2 and thus promoted the degradation of β‐catenin protein, which finally suppressed EMT signaling. Finally, the oncogenic transcription factor c‐Jun bound to ENKUR promoter and reduced its expression in GC. In clinical samples, decreased ENKUR expression promoted the unfavorable prognosis of GC. Our data proved the vital role of ENKUR on suppressing cell migration, invasion, and metastasis and demonstrated its potential as a therapeutic target for GC.
Identification of Biallelic dystrophin gene variants during maternal carrier testing for Becker muscular dystrophy and review of the DMD exon 49–51 deletion phenotype
Authors: Ulm Elizabeth A. , Nagaraj Chinmayee B. , Tian Cuixia , Smolarek Teresa A. 
Published: November 2022

AbstractBackgroundDystrophinopathies are X‐linked recessive conditions caused by pathogenic variants in the dystrophin (DMD) gene. In a family that included two boys with Becker muscular dystrophy (BMD) due to a DMD deletion of exons 45–47, maternal carrier testing unexpectedly identified biallelic DMD deletions of exons 45–47 and 49–51.MethodsThe patient's mild phenotype in the setting of biallelic DMD variants prompted further investigation of the exon 49–51 deletion in particular, via literature review and retrospective chart review of patients who have been evaluated in our institution's comprehensive neuromuscular center and/or diagnosed in our clinical genetic testing laboratory.ResultsTo our knowledge, this is only the fifth case of confirmed biallelic DMD variants in a female. In males, the DMD exon 49–51 deletion appears to result in a mild BMD phenotype with low or normal creatine kinase levels. This deletion comprised 19% (4/21) of dystrophinopathies diagnosed by chromosomal microarray (CMA) in males during the past ten years in our clinical laboratory. Most individuals identified by chart review were diagnosed through CMA, despite the fact that microarray was genome‐wide and not DMD‐specific. This case raised important genetic counseling issues.ConclusionThe DMD exon 49–51 deletion appears to cause a variable but generally mild BMD phenotype. Its relatively frequent detection by CMA suggests it may be underdiagnosed.
HALO: A software tool for real‐time head alignment in the MR scanner
Authors: Zhao Zhiying , Galiana Gigi , Zillo Cristofer , Camarro Terry , Qiu Maolin , Papademetris Xenophon , Hampson Michelle 
Published: November 2022

PurposeMRI studies in human subjects often require multiple scanning sessions/visits. Changes in a subject's head position across sessions result in different alignment between brain tissues and the magnetic field which leads to changes in magnetic susceptibility. These changes can have considerable impacts on acquired signals. Head ALignment Optimization (HALO), a software tool was developed by the authors for active head alignment between sessions.MethodsHALO provides real‐time visual feedback of a subject's current head position relative to the position in a previous session. The tool was evaluated in a pilot sample of seven healthy human subjects.ResultsHALO was shown to enable subjects to actively align their head positions to the desired position of their initial sessions. The subjects were able to improve their head alignment significantly using HALO and achieved good alignment with their first session meeting stringent criteria similar to that used for within‐run head motion (less than 2 mm translation or 2 degrees rotation in any direction from the desired position). Moreover, we found a negative correlation between the post‐alignment rotation and similarity in inter‐session BOLD patterns around the air‐tissue interface near sinus which further highlighted the impact of tissue‐field alignment on BOLD data quality.ConclusionUtilization of HALO in longitudinal studies may help to improve data quality by ensuring the consistency of susceptibility gradients in brain tissues across sessions. HALO has been made publicly available.
The best colleges for adult learners never stop working to improve
Authors: Sutton Halley 
Published: November 2022

“I'm a farm kid. I grew up in a small town in Nebraska — there were a whopping 1,000 people in my town,” Jerrid P. Freeman, Ph.D., Vice President for Student Affairs and Enrollment Management at Northeastern State University in Oklahoma, said. “It was one of those things where college was just not on my radar.” Freeman pursued his undergraduate degree at the University of Nebraska at Kearney while playing sports and came to love the higher education environment, going on to earn his master's and doctorate.
Immigration Policy and Hispanic Representation in National Elections
Authors: Amuedo‐Dorantes Catalina , Bucheli José R. 
Published: November 2022

AbstractFor the first time in U.S. history, after decades of unprecedented growth in interior immigration enforcement disproportionately impacting Latinos, ten percent of the U.S. House of Representatives is Hispanic. Using congressional district‐level data on all candidates participating in general elections to the U.S. House of Representatives between 2008 and 2018, we show that intensified immigration enforcement suppressed Hispanics’ representation in congressional elections. The effect—nonexistent for other minorities, such as non‐Hispanic Black candidates, as well as in primary elections—is driven by local police‐based measures and diminished electoral support. Furthermore, it appears more harmful during midterm elections and in localities without a sanctuary policy.
Erucamide/thermoplastic polyurethane blend with low coefficient of friction, high elasticity and good mechanical properties for intelligent wearable devices
Authors: Jia Tongyu , Tian Hongchi , Liu Suting , Zhang Shijia , Ning Nanying , Yu Bing , Tian Ming 
Published: November 2022

AbstractIn this study, erucamide as a non‐toxic and tasteless lubricant was melt blended with thermoplastic polyurethane (TPU) to reduce the coefficient of friction (COF) of TPU and thus to improve the wearing comfort of intelligent wearable devices. The results show that when the content of erucamide reaches percolation, erucamide can migrate to the TPU surface, forming a layer of lubrication film, and thus significantly reduces the COF of TPU. In addition, erucamide with amide groups can form hydrogen bonds with carbamate groups from TPU chains and thus can disrupt the hydrogen bonds between two amide groups of TPU chains. With the introduction of erucamide, the chain mobility of TPU increases, the partial phase mixing of soft phase and hard phase of TPU occurs, and the interchain interaction between TPU chains decreases. Under the appropriate content of erucamide (0.5 wt%), both the elasticity and processability of TPU are also significantly improved, whereas the high tensile strength, tear strength and elongation at break of the TPU blend is still obtained, facilitating its practical application in intelligent wearable devices. © 2022 Society of Industrial Chemistry.