bluuebunny/crossref_metadata_2025_split huggingface dataset:
Accurate intercensal estimates of energy access to track Sustainable Development Goal 7
Authors: Pokhriyal Neeti , Letouzé Emmanuel , Vosoughi Soroush 
Published: December 2022

AbstractIntercensal estimates of access to electricity and clean cooking fuels at policy planning microregions in a country are essential for understanding their evolution and tracking progress towards Sustainable Development Goals (SDG) 7. Surveys are prohibitively expensive to get such intercensal microestimates. Existing works, mainly, focus on electrification rates, make predictions at the coarse spatial granularity, and generalize poorly to intercensal periods. Limited works focus on estimating clean cooking fuel access, which is one of the crucial indicators for measuring progress towards SDG 7. We propose a novel spatio-temporal multi-target Bayesian regression model that provides accurate intercensal microestimates for household electrification and clean cooking fuel access by combining multiple types of earth-observation data, census, and surveys. Our model’s estimates are produced for Senegal for 2020 at policy planning microregions, and they explain 77% and 86% of variation in regional aggregates for electrification and clean fuels, respectively, when validated against the most recent survey. The diagnostic nature of our microestimates reveals a slow evolution and significant lack of clean cooking fuel access in both urban and rural areas in Senegal. It underscores the challenge of expanding energy access even in urban areas owing to their rapid population growth. Owing to the timeliness and accuracy of our microestimates, they can help plan interventions by local governments or track the attainment of SDGs when no ground-truth data are available.
Mitochondrial DNA Mutations as Natural Barcodes for Lineage Tracing of Murine Tumor Models
Authors: Penter Livius , ten Hacken Elisa , Southard Jackson , Lareau Caleb A. , Ludwig Leif S. , Li Shuqiang , Neuberg Donna S. , Livak Kenneth J. , Wu Catherine J. 
Published: December 2022

AbstractMurine models are indispensable tools for functional genomic studies and preclinical testing of novel therapeutic approaches. Mitochondrial single-cell assay for transposase-accessible chromatin using sequencing (mtscATAC-seq) enables the dissection of cellular heterogeneity and clonal dynamics by capturing chromatin accessibility, copy-number variations (CNV), and mitochondrial DNA (mtDNA) mutations, yet its applicability to murine studies remains unexplored. By leveraging mtscATAC-seq in novel chronic lymphocytic leukemia and Richter syndrome mouse models, we report the detection of mtDNA mutations, particularly in highly proliferative murine cells, alongside CNV and chromatin state changes indicative of clonal evolution upon secondary transplant. This study thus demonstrates the feasibility and utility of multi-modal single-cell and natural barcoding approaches to characterize murine cancer models.Significance:mtDNA mutations can serve as natural barcodes to enable lineage tracing in murine cancer models, which can be used to provide new insights into disease biology and to identify therapeutic vulnerabilities.
Protein Phosphatase 1 Subunit PPP1R14B Stabilizes STMN1 to Promote Progression and Paclitaxel Resistance in Triple-Negative Breast Cancer
Authors: Liao Li , Zhang Yin-Ling , Deng Ling , Chen Chao , Ma Xiao-Yan , Andriani Lisa , Yang Shao-Ying , Hu Shu-Yuan , Zhang Fang-Lin , Shao Zhi-Min , Li Da-Qiang 
Published: December 2022

Abstract

Triple-negative breast cancer (TNBC) represents the most lethal subtype of breast cancer due to its aggressive clinical features and the lack of effective therapeutic targets. To identify novel approaches for targeting TNBC, we examined the role of protein phosphatases in TNBC progression and chemoresistance. Protein phosphatase 1 regulatory subunit 14B (PPP1R14B), a poorly defined member of the protein phosphatase 1 regulatory subunits, was aberrantly upregulated in TNBC tissues and predicted poor prognosis. PPP1R14B was degraded mainly through the ubiquitin–proteasome pathway. RPS27A recruited deubiquitinase USP9X to deubiquitinate and stabilize PPP1R14B, resulting in overexpression of PPP1R14B in TNBC tissues. Gain- and loss-of-function assays demonstrated that PPP1R14B promoted TNBC cell proliferation, colony formation, migration, invasion, and resistance to paclitaxel in vitro. PPP1R14B also induced xenograft tumor growth, lung metastasis, and paclitaxel resistance in vivo. Mechanistic investigations revealed that PPP1R14B maintained phosphorylation and stability of oncoprotein stathmin 1 (STMN1), a microtubule-destabilizing phosphoprotein critically involved in cancer progression and paclitaxel resistance, which was dependent on PP1 catalytic subunits α and γ. Importantly, the tumor-suppressive effects of PPP1R14B deficiency could be partially rescued by ectopic expression of wild-type but not phosphorylation-deficient STMN1. Moreover, PPP1R14B decreased STMN1-mediated α-tubulin acetylation, microtubule stability, and promoted cell-cycle progression, leading to resistance of TNBC cells to paclitaxel. Collectively, these findings uncover a functional and mechanistic role of PPP1R14B in TNBC progression and paclitaxel resistance, indicating PPP1R14B is a potential therapeutic target for TNBC.

Significance:
PPP1R14B upregulation induced by RPS27A/USP9X in TNBC increases STMN1 activity, leading to cancer progression and paclitaxel resistance.
Real-World Multiple Comparison of Transcatheter Aortic Valves: Insights From the Multicenter OBSERVANT II Study
Authors: Costa Giuliano , Barbanti Marco , Rosato Stefano , Seccareccia Fulvia , Tarantini Giuseppe , Fineschi Massimo , Salizzoni Stefano , Valvo Roberto , Tamburino Corrado , Biancari Fausto , Baglio Giovanni , Santoro Gennaro , Baiocchi Massimo , D’Errigo Paola ,   the OBSERVANT II Research Group
Published: December 2022

Background:
Head-to-head comparisons of devices for transcatheter aortic valve implantation (TAVI) are mostly limited to 2-arm studies so far. The aim of this study was to compare simultaneously outcomes of the most used, second- and third-generation transcatheter aortic valves in a real-world population.

Methods:
A total of 2728 patients undergoing TAVI with different second- and third-generation devices, and enrolled in the multicenter, prospective OBSERVANT II study (Observational Study of Effectiveness of TAVI With New Generation Devices for Severe Aortic Stenosis Treatment) from December 2016 to September 2018 were compared according to the transcatheter aortic valve received. Outcomes were adjudicated through a linkage with administrative databases, and adjusted using inverse propensity of treatment weighting. The primary end point was the composite of all-cause death, stroke and rehospitalization for heart failure at 1-year. Rates were reported consecutively for Evolut R, Evolut PRO, SAPIEN 3, ACURATE neo, and Portico groups.

Results:

The primary end point did not differ among groups (23.9% versus 24.7% versus 21.5% versus 23.7% versus 27.4%, respectively,
P
=0.56). Permanent pacemaker implantation was significantly lower for patients receiving SAPIEN 3 (19.9% versus 19.3% versus 12.5% versus 14.7% versus 22.1%, respectively,
P
<0.01) at 1 year. The SAPIEN 3 had lower rates of paravalvular regurgitation (moderate-to-severe grade 10.1% versus 5.0% versus 2.1% versus 13.1% versus 10.8%, respectively,
P
<0.01) but higher transprosthetic gradients (median mean gradients 7.0 versus 6.0 versus 10.0 versus 7.0 versus 8.0 mm Hg, respectively,
P
<0.01) after TAVI.

Conclusions:
Data from real-world practice showed low and comparable rates of complications after TAVI considering all the available devices. Patients receiving SAPIEN 3 valve had lower rates of paravalvular regurgitation and permanent pacemaker implantation, but higher transprosthetic gradients.
Seed priming using Moringa oleifera leaf decoction increases BPT 5204 rice yield
Authors: Kusampudi Varun , Kusampudi Shilpa , B.S. Lakshmi 
Published: December 2022

Abstract
The present study screened different concentrations of Moringa oleifera (M. oleifera) leaf decoction (M. oleifera hot water extract-MWE) (100, 10, 1, and 0.1 g/L) to investigate their potential in increasing the yield of BPT 5204 rice variety. We aimed to analyze the effect of MWE on rice yield with different modes of treatment such as seed soaking, root treatment, and foliar spray. Rice seeds were soaked at different concentrations of MWE for 24 h before seeding. Plants grown from rice seeds soaked in 100 g/L MWE produced 6.6 tons/ha yield, whereas, roots of rice seedlings soaked for 4 h in varied MWE concentrations before transplantation and plants treated with 100 g/L MWE produced an yield of 6 tons/ha. In the last group, 45 day old rice plants were subjected to foliar spray with varying concentrations of MWE, where the foliar spray of rice plants with 100 g/L MWE showed a 6.5 tons/ha yield. As plants grown from rice seeds soaked in 100 g/L MWE produced a high yield, the leaves from these plants were analyzed to study the effect of MWE treatment on phenylalanine lyase and hydrogen peroxide (H2O2) and nitric oxide levels and genes involved in rice yield. The leaves of plants grown from rice seeds soaked in 100 g/L MWE showed increased H2O2 and SAM2 gene levels compared to control plants. This study reports the potential role of MWE as an environmentally safe, cost-effective and easy-to-use biostimulant for enhancing yield of rice.
The Ontology of the City in the Quran: A Study Based on Ibn ‘Āšūr’s Commentaries in the Book of al-Taḥrīr wa al-Tanwīr
Authors: Muhamad  
Published: December 2022

Abstract
Ibn ‘Āšūr was an interdisciplinary commentator. His thoughts on the development and civilization of Islam are remarkable and spectacular. This article discusses Ibn ‘Āšūr’s thoughts on the response of the Quran to one of the civilization issues, especially in the city definition. Ontology dimensions of the city still play an essential role and basis for understanding the urban characteristics in establishing civilizational construction. This study is based on the thematic interpretation method (maudū’ī) by explaining six-city terms according to Ibn Āšūr’s interpretation in the Book al-Taḥrīr wa al-Tanwīr. The findings illustrate that city definition is more context-oriented to the region’s functioning than the linguistic explanation, while the function of an area determines the scale of the city. Overall, this study presents the approach of Ibn ‘Ašūr in exegeting the Quran by combining the Quran sciences with urban theories.
Hadith Palsu Moden Dan Bentuk-Bentuknya Dalam Realiti Semasa
Authors: Ahmad Khadher , Ariffin Mohd Farhan Md , Nasir Mohd Khairulnazrin Mohd 
Published: December 2022

Abstract
The propagation of bogus hadiths within the Muslim community can no longer be ignored due to the advancement of modern technology. The Internet and social media give a platform for the unfettered transmission of any material, including weak and fake hadiths. The purpose of this study is to present a new narrative on fake hadiths and describe the varieties of “contemporary fake hadiths” that are prevalent in the community. All relevant documentary and video information is studied using inductive, deductive, and descriptive methods in order to provide a foundation for a discussion of modern fake hadith along with pertinent examples. According to the findings of the study, a modern fake hadith is a statement that claims to be related to the Prophet Muhammad SAW, whether the statement has a basis of evidence but is misunderstood or does not have a basis of evidence but is associated with the Prophet SAW. The types of modern fake hadith are: [1] testimony and claims of meeting the Prophet accompanied by an alibi. [2] Testimony and assertions from the hadith, but based on a misunderstanding of the hadith’s or text’s content, and, [3] False evidence and assertions that are based directly on the Prophet SAW or not, and are not of the type of false hadith that have been recorded in existing fake hadith publications. In conclusion, the dissemination of erroneous hadith within the community today is not confined to what has been reported in al-Da‘ifat wa al-Mawdu‘at. There are still hadiths and modern fake rumours that continue to expose society to diverse comments and claims attributed to the Prophet SAW for a variety of purposes.
Formation Mechanisms of the Mesoscale Environment Conducive to a Downslope Windstorm over the Cuyamaca Mountains Associated with Santa Ana Wind during the Cedar Fire (2003)
Authors: Karim S. M. Shajedul , Lin Yuh-Lang , Kaplan Michael L. 
Published: December 2022

Abstract
Numerical simulations were conducted to investigate the upstream environment’s impacts on the airflow over the lee slope of the Cuyamaca Mountains (CM) near San Diego, California, during the Cedar Fire that occurred from 25 to 29 October 2003. The upstream environment was largely controlled by a southwest–northeast-oriented upper-tropospheric jet streak that rotated around a positively tilted ridge within the polar jet stream. Three sequential dynamical processes were found to be responsible for modifying the mesoscale environment conducive to low-level momentum and dry air that sustained the Cedar Fire. First, the sinking motion associated with the indirect circulation of the jet streak’s exit region strengthened the midtropospheric flow over the southern Rockies and the lee slope of the Sawatch and San Juan Ranges, thus modestly affecting the airflow by enhancing the downslope wind over the CM. Second, consistent with the coupling process between the upper-level sinking motion, downward momentum transfer, and developing lower-layer mountain waves, a wave-induced critical level over the mountain produced wave breaking, which was characterized by a strong turbulent mixed region with a wind reversal on top of it. This critical level helped to produce severe downslope winds leading to the third stage: a hydraulic jump that subsequently enhanced the downstream extent of the strong winds conducive to the favorable lower-tropospheric environment for rapid fire spread. Consistent with these findings was the deep-layer resonance between the mountain surface and tropopause, which had a strong impact on strengthening the severe downslope winds over the lee slope of the CM accompanying the elevated strong easterly jet at low levels.
The Role of Surface Fluxes in MJO Propagation through the Maritime Continent
Authors: Hudson Justin , Maloney Eric 
Published: December 2022

Abstract
The “barrier effect” of the Maritime Continent (MC) is a known hurdle in understanding the propagation of the Madden–Julian oscillation (MJO). To understand the differing dynamics of MJO events that propagate versus stall over the MC, a new tracking algorithm utilizing 30–96-day-filtered NOAA Interpolated OLR anomalies is presented. Using this algorithm, MJO events can be identified, tracked, and described in terms of their propagation characteristics. Latent heat flux from OAFlux and CYGNSS surface winds and fluxes are compared for MJO events that do and do not propagate through the MC. Events that successfully propagate through the MC demonstrate regional surface flux anomalies that are stronger, more spatially coherent, and have a larger fetch. The spatial scale of convective anomalies for events that successfully propagate through the MC region is also larger than for terminating events. Large-scale enhancement of latent heat fluxes near and to the east of the date line, equally driven by dynamic and thermodynamic effects, also accompanies MJO events that successfully propagate through the MC. These findings are placed in the context of recent theoretical models of the MJO in which latent heat fluxes are important for propagation and destabilization.
Chemosensory Dysfunction 3-Months After COVID-19, Medications and Factors Associated with Complete Recovery
Authors: Fornazieri Marco Aurélio , Silva José Lucas Barbosa da , Gameiro Juliana Gutschow , Scussiato Henrique Ochoa , Ramos Rafael Antônio Matias Ribeiro , Cunha Bruno Machado , Figueiredo Alan Felipe , Takahashi Eduardo Hideki , Marin Gabrielli Algazal , Caetano Igor Ruan de Araújo , Meli Tainara Kawane , Higuchi Diego Issamu , Santos Rafael Rodrigues Pinheiro dos , Rampazzo Ana Carla Mondek , Pinna Fábio de Rezende , Voegels Richard Louis , Doty Richard L. 
Published: December 2022

Objectives: To examine the longitudinal prevalence and recovery of olfactory, gustatory, and oral chemesthetic deficits in a sizable cohort of SARS-CoV-2 infected persons using quantitative testing. To determine whether demographic and clinical factors, mainly the medications used after the COVID-19 diagnosis, influence the test measures. Methods: Prospective cohort in a hospital with primary, secondary, tertiary, and quaternary care. Patients with confirmed COVID-19 were tested during the acute infection phase (within 15 days of initial symptom, n = 187) and one (n = 113) and 3 months later (n = 73). The University of Pennsylvania Smell Identification Test, the Global Gustatory Test, and a novel test for chemesthesis were administered at all visits. Results: During the acute phase, 93% were anosmic or microsmic and 29.4% were hypogeusic. No one was ageusic. A deficit in oral chemesthesis was present in 13.4%. By 3 months, taste and chemesthesis had largely recovered, however, some degree of olfactory dysfunction remained in 54.8%. Remarkably, patients who had been treated with anticoagulants tended to have more olfactory improvement. Recovery was greater in men than in women, but was unrelated to disease severity, smoking behavior, or the use of various medications prior to, or during, COVID-19 infection. Conclusions: When using quantitative testing, olfactory disturbances were found in nearly all SARS-CoV-2 infected patients during the acute infection phase. Taste or chemesthetic deficits were low. Olfactory impairment persisted to some degree in over half of the patients at the 3-month follow-up evaluation, being more common in women and less common in those who had been treated earlier with anticoagulants. Level of Evidence: 3
Farm Laws: Regulation-revolution?—Assessing the Need, Intent and Impact of the New Farm Laws from an Economic Perspective
Authors: Mehta Sanjana 
Published: December 2022

In September 2020, through a voice vote in the Rajya Sabha, the Indian Parliament passed the infamous three farm bills. This triggered a series of protests and resistance that manifested in one of the world’s biggest displays of dissent. A lot has been said about the intent and potential impact of the farm bills. India is a majorly agricultural economy, so not only do these farm bills hold the potential to disrupt our economy, the protests it has triggered are further indicative of a radical change. This article breaks down the intent of the now-repealed legislation, its potential impact on the economy, positive and negative, and how the resultant protests have impacted a country headed towards a recessionary period. The article marks battles won and lost, and paves a potential path forward. JEL Code: E6
The exploration of shared genes and molecular mechanisms of systemic lupus erythematosus and atherosclerosis
Authors: Fan Ji-Lin , Wu Di , Zhu Ting-Ting , Tian Xiao-Ling , Liu Si-Jia , Zhang Shi-Liang 
Published: December 2022

Objective Despite widespread recognition, the mechanisms underlying the relationship between systemic lupus erythematosus (SLE) and atherosclerosis (AS) are still unclear. Our study aimed to explore the shared genetic signature and molecular mechanisms of SLE and AS using a bioinformatics approach. Methods Gene expression profiles of GSE50772 (contains peripheral blood mononuclear cells from 61 SLE patients and 20 normal samples) and GSE100927 (contains 69 AS plaque tissue samples and 35 control samples) were downloaded from the Gene Expression Database (GEO) before the differentially expressed genes were obtained using the “limma” package in R. The differential genes were then subjected to gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis using the DAVID online platform to annotate their functions. The intersection targets of PPI and WGCNA were used as key shared genes for SLE and AS with their diagnostic value as shared genes being verified through ROC curves. Finally, Cytoscape 3.7.2 software was used to construct a miRNA-mRNA network map associated with the shared genes. Results A total of 246 DEGs were identified, including 189 upregulated genes and 57 downregulated genes, which were mainly enriched in signaling pathways such as TNF signaling pathway, IL-17 signaling pathway, and NF-kB signaling pathway. The molecular basis for the relationship between SLE and AS may be the aforementioned signaling pathways. Following ROC curve validation, the intersection of PPI and WGCNA, as well as AQP9, CCR1, CD83, CXCL1, and FCGR2A, resulted in the identification of 15 shared genes. Conclusion The study provided a new perspective on the common molecular mechanisms between SLE and AS, and the key genes and pathways that were identified as being part of these pathways may offer fresh perspectives and suggestions for further experimental research.
Electroacupuncture inhibits hippocampal neuronal apoptosis and improves cognitive dysfunction in mice with vascular dementia via the JNK signaling pathway
Authors: Liu Yaru , Yan Zhenyang , Ren Yafei , Wang Woyu , Ke Yinze , Wang Yifan , Qi Rongming 
Published: December 2022

Background: Electroacupuncture (EA) has been shown to reduce cognitive impairment in vascular dementia (VaD) patients. However, the mechanism of action remains unknown. Objective: The c-Jun N-terminal kinase (JNK) signaling pathway plays an important role in apoptosis. Herein, we focused on whether EA can inhibit apoptosis and alleviate cognitive impairment by regulating the JNK signaling pathway using a mouse model of VaD induced by modified bilateral common carotid artery occlusion (BCCAo). Methods: In experiment I, 60 mice were randomly divided into a Sham group, BCCAo group, BCCAo + EA group, BCCAo + Sham-EA group, BCCAo + SP group (receiving the selective JNK inhibitor SP600125) and BCCAo + SP + EA group. Morris water maze tests, TdT-mediated dUTP-biotin nick end labeling (TUNEL) staining and flow cytometry were used to evaluate the effect of the EA intervention on VaD. In experiment II, 30 mice were randomly divided into a Sham group, BCCAo group, BCCAo + EA group, BCCAo + SP group and BCCAo + SP + EA group. Western blotting and real-time reverse transcription polymerase chain reaction were used to detect protein and mRNA expression of key factors in the JNK signaling pathway in the hippocampus. Results: EA, SP600125 and EA + SP600125 significantly inhibited hippocampal apoptosis and improved cognitive impairment in VaD model mice. There were no significant differences between the BCCAo group and the BCCAo + Sham-EA group. EA, EA + SP600125 and SP600125 inhibited the phosphorylation of JNK and caspase-3. EA and EA + SP600125 promoted protein and mRNA expression of B-cell lymphoma 2 (Bcl-2) in the hippocampus of VaD mice and inhibited protein and mRNA expression of activator protein (AP)-1, p53 and Bax. Conclusion: EA can reverse cognitive deficits and inhibit hippocampal neuronal apoptosis in VaD model mice, at least partially through inhibition of the JNK signaling pathway and regulation of apoptosis signals.