bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficiency of methods of strengthening foundations of environmental buildings with a significed influence from the construction of the metroline line
Authors: Tugay A.A. , Hryhorovskyi P.Y. , Basanskyi V.O. , Lіalko V.V. 
Published: July 2022

A section of the Syretsko-Pecherska metro line is being built in Kyiv. Subway line tunnels are built in a partially open way. In the area of the picket PK-2 pit construction of the subway is an existing building on Ave. Truth 68, which is located in the zone of possible influence. The impact on the construction of surrounding buildings occurs at different stages of the existence of subway tunnels: the construction of tunnels with open pits and the stage of operation of subway tunnels with vibration during train traffic.
At the stage of construction of subway tunnels, deformations of the soil base under existing buildings occur during the development of soil in the middle of the pit, which leads to uneven subsidence of buildings. The article investigates the effectiveness of methods of strengthening the foundations of the surrounding buildings with a certain impact from the construction of the subway line.
To determine the most effective option of strengthening the foundations of the house in the construction of tunnels of the subway line, variable calculations were performed using different schemes of strengthening the foundations to determine the optimal ratio of labor costs to ensure strength and minimize deformation in each way. Taking into account the constructive scheme of the building, engineering and geological conditions of the construction site and technological possibilities of non-destructive reinforcement of the foundations, the following reinforcement options were considered: installation of the foundation slab; injection of reinforcing solution of the foundation base; arrangement of micropiles.
Calculations of the system "pit - soil - building" were performed in the software and calculation complex "PLAXIS 2D" by the finite element method.
Given that the greatest influence on the occurrence of defects in the structures of the building will give the parameter of non-uniformity of deformations, the comparison of the reinforcement efficiency was determined by this parameter.
The smallest non-uniformity of deformations was provided by means of strengthening by a base plate. Compared to this method, the reinforcement of the foundation foundation injection with 89% more non-uniform deformations gave the reinforcement solution, and 296% more non-uniform deformations with micro-field reinforcement. The most effective way to strengthen the foundations of the building is to install a foundation slab with a compaction of the base with a self-expanding polymeric material.
Pengelolaan Manajemen Usaha pada Kelompok Pengrajin Batik Sekar Cantrik Temanggung
Authors: Supaya Sandi , Mardinawati Mardinawati , Wibowo Bagus Yunianto 
Published: July 2022

<p>Tujuan dari program pengabdian masyarakat ini adalah membuat perhitungan harga pokok produk batik , dan laporan laba rugi, serta dapat meningkatkan kualitas produk kain batik cap. Permasalahan yang dihadapi mitra adalah belum mampu menghitung harga pokok produk, dan laporan laba rugi, serta kualitas batik cap masih rendah. Dari permasalahan tersebut solusi yang diberikan adalah praktek menghitung harga pokok produk batik, dan laporan laba rugi, serta penambahan peralatan batik cap yang memenuhi standar. Metode pendekatan yang digunakan adalah praktek menghitung harga pokok produksi dan laba rugi, praktek menggunakan peralatan batik cap, pendampingan usaha dan monitoring. Hasil kegiatan ini adalah dokumen perhitungan harga pokok produksi, dokumen laba rugi dan kain batik cap. Kesimpulan dari kegiatan pengabdian masyarakat ini adalah peningkatan kemampuan mitra dalam mengelola usaha, dan menghitung harga pokok produk batik. Saran diberikan untuk pengembangan dan program pengabdian lanjutan adalah peningkatan mitra pengabdian dari UKM atau Kelompok Usaha Bersama menjadi Industri Kecil Menengah.</p>
La igualdad de género en el cine de animación Rompiendo el techo laboral del sector audiovisual
Authors: YEBENES CORTES Pilar Pilar 
Published: July 2022

<p>El cine de animación adolece aún de una excesiva presencia de hombres en su seno, lo que tradicionalmente ha relegado a las mujeres casi a la invisibilidad, abocándolas, todavía hoy, a una lucha ardua por reafirmar su talento en la cinematografía española. Sólo cuatro mujeres han aparecido en los títulos de crédito en la Dirección de Animación. En muchas otras categorías que conforman el armazón de cualquier producción cinematográfica, las técnicas de iluminación, realizadoras, productoras, fotógrafas, montadoras, directoras de efectos digitales, diseñadoras de vestuario, constituyen un número escandalosamente bajo. El presente artículo pretende reflexionar y arrojar luz sobre esta situación tratando de despejar algunas de las preguntas, recurrentes y oportunas, respecto a la necesidad de abrir campo y oportunidades a un inmenso caudal de talento que tanta falta hace a nuestro cine y que en lo que a las mujeres respecta ha estado invisible y oculto durante décadas. La evolución del papel de la mujer y del cine de animación parte de una investigación iniciada hace veinte años con <em>Cine de animación en España</em> (Yébenes, 2002) y que ha continuado mostrando los diferentes datos contrastados de las producciones de animación nacional que se han generado en <em>100 años de animación, arte y tecnología</em> (Yébenes, 2017). El informe MIA 2021 integrado por el equipo de investigación de mujeres de la industria de la animación constituye una investigación social con perspectiva de género que completa nuestras voces que pretenden proyectar la realidad mostrando resultados de representación de nuestro trabajo en la animación actual. Se incorporan en este artículo preguntas desarrollas estrictamente a mujeres dedicadas a la animación para ampliar la sensibilidad social en este campo.</p><p><strong> </strong></p>
Late plasma exosome microRNA-21-5p depicts magnitude of reverse ventricular remodeling after early surgical repair of primary mitral valve regurgitation
Authors: Pizzino Fausto , Furini Giulia , Casieri Valentina , Mariani Massimiliano , Bianchi Giacomo , Storti Simona , Chiappino Dante , Maffei Stefano , Solinas Marco , Aquaro Giovanni Donato , Lionetti Vincenzo 
Published: July 2022

IntroductionPrimary mitral valve regurgitation (MR) results from degeneration of mitral valve apparatus. Mechanisms leading to incomplete postoperative left ventricular (LV) reverse remodeling (Rev–Rem) despite timely and successful surgical mitral valve repair (MVR) remain unknown. Plasma exosomes (pEXOs) are smallest nanovesicles exerting early postoperative cardioprotection. We hypothesized that late plasma exosomal microRNAs (miRs) contribute to Rev–Rem during the late postoperative period.MethodsPrimary MR patients (n = 19; age, 45–71 years) underwent cardiac magnetic resonance imaging and blood sampling before (T0) and 6 months after (T1) MVR. The postoperative LV Rev–Rem was assessed in terms of a decrease in LV end-diastolic volume and patients were stratified into high (HiR-REM) and low (LoR-REM) LV Rev–Rem subgroups. Isolated pEXOs were quantified by nanoparticle tracking analysis. Exosomal microRNA (miR)-1, –21–5p, –133a, and –208a levels were measured by RT-qPCR. Anti-hypertrophic effects of pEXOs were tested in HL-1 cardiomyocytes cultured with angiotensin II (AngII, 1 μM for 48 h).ResultsSurgery zeroed out volume regurgitation in all patients. Although preoperative pEXOs were similar in both groups, pEXO levels increased after MVR in HiR-REM patients (+0.75-fold, p = 0.016), who showed lower cardiac mass index (–11%, p = 0.032). Postoperative exosomal miR-21-5p values of HiR-REM patients were higher than other groups (p &lt; 0.05). In vitro, T1-pEXOs isolated from LoR-REM patients boosted the AngII-induced cardiomyocyte hypertrophy, but not postoperative exosomes of HiR-REM. This adaptive effect was counteracted by miR-21-5p inhibition.Summary/ConclusionHigh levels of miR-21-5p-enriched pEXOs during the late postoperative period depict higher LV Rev–Rem after MVR. miR-21-5p-enriched pEXOs may be helpful to predict and to treat incomplete LV Rev–Rem after successful early surgical MVR.
Efficacy and safety of Wenxin Keli combined with metoprolol tartrate in the treatment of premature ventricular contractions: A systematic review and meta-analysis
Authors: Huang Ping , Luo Yining , Chen Jiaxue , Xu Jingke , Shi Yuanshu , Chen Guoren , Ma Ping 
Published: July 2022

BackgroundWenxin Keli (WXKL) has good clinical value in the treatment of premature ventricular contractions, but there is insufficient evidence to support it. This study evaluates the efficacy and safety of WXKL combined with metoprolol tartrate in the treatment of ventricular premature beats (VPCs).MethodsWe searched seven databases to identify randomized controlled trials (RCTs) for this study. Two reviewers independently screened and extracted the data. The Cochrane Manual criteria were used for methodological quality assessment. Meta-analyses were performed using Review Manager 5.4.1 software. Risk ratios (RR) were used for effect sizes for dichotomous data, demonstrated in effect sizes and 95% confidence intervals (CIs).ResultsA total of 11 RCTs of WXKL combined with metoprolol tartrate in the treatment of premature ventricular contractions were included in this study. Meta-analysis showed that WXKL combined with metoprolol tartrate (treatment group) was more effective than metoprolol tartrate (control group) in improving premature ventricular contractions (RR = 1.32, 95% CI: [1.24, 1.40], P &lt; 0.00001); significantly improved the rate of premature ventricular contractions (RR = 1.32, 95% CI: [1.23, 1.41], P &lt; 0.00001); there was no difference in adverse drug reactions compared with the control group (RR = 0.61, 95% CI: [0.35, 0.1.05], P = 0.08), but the number of adverse reactions (n = 18) was less than that of the control group (n = 32), and the severity was lower than that of the control group. The included studies only mentioned randomization and did not describe the generation of random sequences in detail.ConclusionThis study found that Wenxin Keli combined with metoprolol tartrate in the treatment of premature ventricular contractions increased the efficacy of the drug, reduced the occurrence of adverse reactions, and reduced the severity of adverse reactions. Due to the quality limitations of the included studies, more high-quality RCTs are needed in the future to provide more evidence for longer-term analyses.
Effect of electroacupuncture on the intestinal microflora in rats with stress urinary incontinence
Authors: Li Chaonan , Qu Zhiyu , Liu Jiandang , Ruan Shuoquan , Chen Bingli , Ran Jinchuan , Shu Wen , Chen Yuelai , Hou Wenguang 
Published: July 2022

ObjectiveTo examine the effect of electroacupuncture on the urodynamics and gut microbiota of rats with stress urinary incontinence (SUI).Materials and methodsThirty 2-month-old female Sprague–Dawley (SD) rats were randomly assigned to 4 groups: normal (N), model (M), nonacupoint electric acupuncture control (NAAC), and electroacupuncture (EA). An SUI rat model was established through vaginal balloon dilatation and bilateral oophorectomy. After various treatments, urodynamic tests were performed, and feces were collected. 16S rRNA sequencing analysis was used to investigate SUI-related changes in the intestinal flora.ResultsAfter treatment, compared with those of the M group, the leak point pressure and maximum bladder capacity of the electroacupuncture groups increased (P&lt;0.05). The species community compositions of the N and M groups differed at the genus level, and there were 15 differentially abundant bacterial genera (P&lt;0.05). The Blautia proportion was increased by electroacupuncture treatment (P&lt;0.05) and was significantly positively correlated with the electroacupuncture treatment of SUI (according to Spearman correlation analysis).ConclusionElectroacupuncture treatment can improve signs of urine leakage in rats with SUI rats by increasing the leak point pressure and maximum bladder capacity. The enrichment of Blautia by electroacupuncture treatment enrichment may be related to SUI sign improvement.
The clinical characteristics of Chinese elderly patients with different durations of type 2 diabetes mellitus
Authors: Yu Yun , Xie Kaipeng , Lou Qinglin , Xia Hui , Wu Dan , Dai Lingli , Hu Cuining , Shan Shan , Wang Kunlin , Tang Wei 
Published: July 2022

AimsTo explore the clinical characteristics among elderly (aged ≥60 years) patients with type 2 diabetes (T2DM) of different durations.MethodsClinical characteristics were investigated in 3840 elderly T2DM patients according to their different durations of diabetes (&lt; 1 year, 1~5 years, 5~10 years, and ≥ 10 years). Kruskal-Wallis and Dunn tests were used to assess the differences among groups for continuous variables. The chi-square and post hoc tests were carried out for dichotomous variables. The logistic regression was adopted to investigate the relationships between various durations of diabetes and the control rates of achieving the control targets for T2DM as well as diabetic vascular complications.ResultsThere were 972, 896, 875 and 1097 patients with a duration of diabetes of &lt;1, 1~5, 5~10 and ≥10 years, respectively. In logistic regression models adjusted for age, sex, education, BMI, smoking and family history of diabetes, elderly T2DM patients with a duration of diabetes of ≥10 years were more likely to reach the comprehensive control targets for TC (ORTC = 1.36, 95% CI =1.14-1.63), LDL-C (ORLDL-C = 1.39, 95% CI =1.17-1.66), TG (ORTG = 1.76, 95% CI =1.46-2.12) and BMI (ORBMI = 1.82, 95% CI =1.52-2.18). Elderly T2DM patients with a duration of diabetes of 1~5 years were more likely to achieve the HbA1c control target (ORHbA1c = 1.92, 95% CI = 1.59-2.31) than elderly T2DM patients with a duration of diabetes of &lt;1 year. Furthermore, in elderly T2DM patients with a duration of diabetes of 5~10 years or ≥ 10 years, the duration of diabetes was positively associated with diabetic macrovascular complications (coronary heart disease and peripheral artery disease). In elderly T2DM patients with a duration of diabetes of over 10 years, the duration of diabetes was associated with diabetes kidney disease (all P &lt; 0.05).ConclusionsIt is worth noting that the clinical characteristics of elderly patients with type 2 diabetes in different durations of diabetes are different.
Alanine aminotransferase to aspartate aminotransferase ratio and hepatitis B virus on metabolic syndrome: a community-based study
Authors: Lin Ming-Shyan , Lin Huang-Shen , Chang Ming-Ling , Tsai Ming-Horng , Hsieh Yung-Yu , Lin Yu-Sheng , Tsai Meng-Shu , Yang Chia-Ling , Chen Mei-Yen 
Published: July 2022

BackgroundThe serum aminotransferase elevation in metabolic syndrome (MetS) reflected hepatosteatosis, but there is a conflict with the coexistence of viral hepatitis, especially for the hepatitis B virus (HBV). Thus, this study aimed to investigate the relationship between the alanine aminotransferase (ALT)/aspartate aminotransferase (AST) ratio, MetS, and HBV infection in a rural Taiwanese population.MethodsWe conducted a cross-sectional analysis in southern Taiwan between March and December 2019. Multivariable logistic regression analyses adjusted for demographics, education, dietary behaviors, irregular exercise, substance use, and viral markers were performed to investigate the association between the ALT/AST ratio and MetS.ResultsAltogether, 2,416 participants (891 men and 1,525 women; mean age, 64.1 ± 14.9 years) were enrolled. Of the participants, 22.7% (n = 519) were seropositive for viral hepatitis. In the multivariable analysis, age [odds ratio (OR) 1.02, 95% CI 1.01–1.03, p &lt; 0.001], ALT/AST ratio &gt;1 (OR 2.63, 95% CI 2.15–3.21, p &lt; 0.001), education (OR 0.96, 95% CI 0.94–0.98, p &lt; 0.001), and HBV seropositivity (OR 0.70, 95% CI 0.52–0.95, p = 0.021) were associated with the risk of MetS. The area under the curve of the ALT/AST ratio was 0.62 (95% CI 0.60–0.64, p &lt; 0.001), and the cutoff value was &gt;0.852 for the Youden index.ConclusionAn ALT/AST ratio &gt;1 could be a simple index for MetS prediction during community checkups. In contrast to age and betel nut chewing, HBV seropositivity and higher education might be inversely associated with MetS. Aggressive health promotion for MetS prevention has emerged as essential in participants without HBV and with lower education levels. Further large-scale, longitudinal studies are needed to unlink these correlations.
Obesity and clinical outcomes in COVID-19 patients without comorbidities, a post-hoc analysis from ORCHID trial
Authors: Yu Peng , Tan Ziqi , Li Zhangwang , Xu Yi , Zhang Jing , Xia Panpan , Tang Xiaoyi , Ma Jianyong , Xu Minxuan , Liu Xiao , Shen Yunfeng 
Published: July 2022

ObjectiveLarge body of studies described individuals with obesity experiencing a worse prognosis in COVID-19. However, the effects of obesity on the prognosis of COVID-19 in patients without comorbidities have not been studied. Therefore, the current study aimed to provide evidence of the relationship between obesity and clinical outcomes in COVID-19 patients without comorbidities.MethodsA total of 116 hospitalized COVID-19 patients without comorbidities from the ORCHID study (Patients with COVID-19 from the Outcomes Related to COVID-19 Treated with Hydroxychloroquine among Inpatients with Symptomatic Disease) were included. Obesity is defined as a BMI of ≥30 kg/m2. A Cox regression analysis was used to estimate the hazard ratio (HR) for discharge and death after 28 days.ResultsThe percentage of obesity in COVID-19 patients without comorbidities was 54.3% (63/116). Discharge at 28 days occurred in 56/63 (84.2%) obese and 51/53 (92.2%) non-obese COVID-19 patients without comorbidities. Four (3.4%) COVID-19 patients without any comorbidities died within 28 days, among whom 2/63 (3.2%) were obese and 2/53 (3.8%) were non-obese. Multivariate Cox regression analyses showed that obesity was independently associated with a decreased rate of 28-day discharge (adjusted HR: 0.55, 95% CI: 0.35–0.83) but was not significantly associated with 28-day death (adjusted HR: 0.94, 95% CI: 0.18–7.06) in COVID-19 patients without any comorbidities.ConclusionsObesity was independently linked to prolonged hospital length of stay in COVID-19 without any comorbidity. Larger prospective trials are required to assess the role of obesity in COVID-19 related deaths.
Serum concentration of extracellular cold-inducible RNA-binding protein is associated with respiratory failure in COVID-19
Authors: Schagatay Felix , Diamant Klara , Lidén Mats , Edin Alicia , Athlin Simon , Hultgren Olof , Ahlm Clas , Forsell Mattias N. E. , Savilampi Johanna , Normark Johan , Lange Anna , Cajander Sara 
Published: July 2022

Uncontrolled release of damage-associated molecular patterns (DAMPs) is suggested to be a major trigger for the dysregulated host immune response that leads to severe COVID-19. Cold-inducible RNA-binding protein (CIRP), is a newly identified DAMP that aggravates inflammation and tissue injury, and induces respiratory failure in sepsis. Whether CIRP contributes to the pathogenesis of respiratory failure in COVID-19 has not yet been explored.AimTo investigate if the concentration of extracellular CIRP (eCIRP) in serum associates with respiratory failure and lung involvement by chest computed tomography (CT) in COVID-19.MethodsHerein we report a prospective observational study of patients with COVID-19 included at two University Hospitals in Sweden between April 2020 and May 2021. Serum from hospitalized patients in Örebro (N=97) were used to assess the association between eCIRP and the level of respiratory support and its correlation with pulmonary involvement on chest CT and inflammatory biomarkers. A cohort of hospitalized and non-hospitalized patients from Umeå (N=78) was used as an external validation cohort. The severity of disease was defined according to the highest degree of respiratory support; mild disease (no oxygen), non-severe hypoxemia (conventional oxygen or high-flow nasal oxygen, HFNO &lt;50% FiO2), and severe hypoxemia (HFNO ≥50% FiO2, mechanical ventilation). Unadjusted and adjusted linear regression was used to evaluate peak eCIRP day 0-4 in respect to severity, age, sex, Charlson comorbidity score, symptom duration, and BMI.ResultsPeak eCIRP concentrations were higher in patients with severe hypoxemia and were independently associated with the degree of respiratory support in both cohorts (Örebro; p=0.01, Umeå; p&lt;0.01). The degree of pulmonary involvement measured by CT correlated with eCIRP, rs=0.30, p&lt;0.01 (n=97).ConclusionHigh serum levels of eCIRP are associated with acute respiratory failure in COVID-19. Experimental studies are needed to determine if treatments targeting eCIRP reduces the risk of acute respiratory failure in COVID-19.
Soluble markers of B cell activation suggest a role of B cells in the pathogenesis of systemic sclerosis-associated pulmonary arterial hypertension
Authors: Sanges Sébastien , Guerrier Thomas , Duhamel Alain , Guilbert Lucile , Hauspie Carine , Largy Alexis , Balden Maïté , Podevin Céline , Lefèvre Guillaume , Jendoubi Manel , Speca Silvia , Hachulla Éric , Sobanski Vincent , Dubucquoi Sylvain , Launay David 
Published: July 2022

IntroductionSoluble markers of B cell activation are interesting diagnostic and prognostic tools in autoimmune diseases. Data in systemic sclerosis (SSc) are scarce and few studies focused on their association with disease characteristics.Methods1. Serum levels of 14 B cell biomarkers (β2-microglobulin, rheumatoid factor (RF), immunoglobulins (Ig) G, IgA, IgM, BAFF, APRIL, soluble (s)TACI, sBCMA sCD21, sCD23, sCD25, sCD27, CXCL13) were measured in SSc patients and healthy controls (HC). 2. Associations between these biomarkers and SSc characteristics were assessed. 3. The pathophysiological relevance of identified associations was explored by studying protein production in B cell culture supernatant.ResultsIn a discovery panel of 80 SSc patients encompassing the broad spectrum of disease manifestations, we observed a higher frequency of RF positivity, and increased levels of β2-microglobulin, IgG and CXCL13 compared with HC. We found significant associations between several biomarkers and SSc characteristics related to disease phenotype, activity and severity. Especially, serum IgG levels were associated with pulmonary hypertension (PH); β2-microglobulin with Nt-pro-BNP and DLCO; and BAFF with peak tricuspid regurgitation velocity (TRV). In a validation cohort of limited cutaneous SSc patients without extensive ILD, we observed lower serum IgG levels, and higher β2-microglobulin, sBCMA, sCD23 and sCD27 levels in patients with pulmonary arterial hypertension (PAH). BAFF levels strongly correlated with Nt-pro-BNP levels, FVC/DLCO ratio and peak TRV in SSc-PAH patients. Cultured SSc B cells showed increased production of various angiogenic factors (angiogenin, angiopoietin-1, VEGFR-1, PDGF-AA, MMP-8, TIMP-1, L-selectin) and decreased production of angiopoietin-2 compared to HC.ConclusionSoluble markers of B cell activation could be relevant tools to assess organ involvements, activity and severity in SSc. Their associations with PAH could plead for a role of B cell activation in the pathogenesis of pulmonary microangiopathy. B cells may contribute to SSc vasculopathy through production of angiogenic mediators.