bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Randomized, Placebo‐Controlled Study of Methotrexate to Increase Response Rates in Patients with Uncontrolled Gout Receiving Pegloticase: Primary Efficacy and Safety Findings
Authors: Botson John K. , Saag Kenneth , Peterson Jeff , Parikh Naval , Ong Stephen , La Dan , LoCicero Karon , Obermeyer Katie , Xin Yan , Chamberlain Jason , LaMoreaux Brian , Verma Supra , Sainati Stephen , Grewal Suneet , Majjhoo Amar , Tesser John R. P. , Weinblatt Michael E. 
Published: September 2022

ObjectiveTo assess efficacy, safety, pharmacokinetics, and immunogenicity of pegloticase plus methotrexate (MTX) versus pegloticase plus placebo cotreatment for uncontrolled gout in a randomized, placebo‐controlled, double‐blind trial.MethodsThis study included adults with uncontrolled gout, defined as serum urate ≥7 mg/dl, oral urate‐lowering therapy failure or intolerance, and presence of ongoing gout symptoms including ≥1 tophus, ≥2 flares in the past 12 months, or gouty arthritis. Key exclusion criteria included MTX contraindication, current immunosuppressant use, G6PDH deficiency, and estimated glomerular filtration rate <40 ml/minute/1.73 m2. Patients were randomized 2:1 to 52 weeks of pegloticase (8 mg biweekly) with either oral MTX (15 mg/week) or placebo. The primary end point was the proportion of treatment responders during month 6 (defined as serum urate <6 mg/dl for ≥80% of visits during weeks 20–24). Efficacy was evaluated in all randomized patients (intent‐to‐treat population), and safety was evaluated in all patients receiving ≥1 blinded MTX or placebo dose.ResultsA total of 152 patients were randomized, 100 to receive pegloticase plus MTX, 52 to receive pegloticase plus placebo. Significantly higher treatment response occurred during month 6 in the MTX group versus the placebo group (71.0% [71 of 100 patients] versus 38.5% [20 of 52 patients], respectively; between‐group difference 32.3% [95% confidence interval 16.3%, 48.3%]) (P < 0.0001 for between‐group difference). During the first 6 months of pegloticase plus MTX or pegloticase plus placebo treatment, 78 (81.3%) of 96 MTX patients versus 47 (95.9%) of 49 placebo patients experienced ≥1 adverse event (AE), most commonly gout flare (64 [66.7%] of 96 MTX patients and 34 [69.4%] of 49 placebo patients). Reports of AEs and serious AEs were comparable between groups, but the infusion reaction rate was considerably lower with MTX cotherapy (4.2% [4 of 96 MTX patients, including 1 patient who had anaphylaxis]) than with placebo cotherapy (30.6% [15 of 49 placebo patients, 0 who had anaphylaxis]) (P < 0.001). Antidrug antibody positivity was also lower in the MTX group.ConclusionMTX cotherapy markedly increased pegloticase response rate over placebo (71.0% versus 38.5%) during month 6 with no new safety signals. These findings verify higher treatment response rate, lower infusion reaction incidence, and lower immunogenicity when pegloticase is coadministered with MTX.
Morphology‐ and composition‐controlled silver‐containing rhodium nanoparticles for the oxygen reduction reaction
Authors: Hwang Gyu Seop , Shin Woojun , Yim Gyeonghye , Choi Jae Hyuk , Kim Young‐Kwan , Jang Hongje , Kim Yang‐Rae 
Published: September 2022

AbstractRh nanoparticles (RhNPs) have attracted significant attention due to their superior electrocatalytic activity in several energy conversion reactions. However, studies relating their morphology and performance are rare. In this study, three types of RhNPs, i.e., nanoshells, nanoframes, and porous nanoplates, were synthesized via inverse‐directional galvanic replacement. The relationship between the performance of the RhNPs at catalyzing the oxygen reduction reaction (ORR) and their morphology was investigated using cyclic voltammetry, linear sweep voltammetry, the Tafel slope, and electrochemical impedance spectroscopy. X‐ray photoelectron spectroscopy and X‐ray diffraction data revealed that the RhNPs contained different Rh/Ag ratios. All the RhNPs exhibited long‐term stability under acidic conditions. In particular, nanoshell‐structured RhNPs exhibited superior ORR activity as determined from the slope of the Tafel plot, the number of electrons, and the onset potential compared to a commercial Rh electrocatalyst and other RhNPs. Evidently, controlling the morphology and composition of RhNPs greatly facilitates efficient electrocatalysis.
Serum metabolomics using ultra‐high performance liquid chromatography–Q‐Exactive tandem mass spectrometry reveals the mechanism of action of exercise training on chronic obstructive pulmonary disease rats
Authors: Du Yan , Wu Jing , Tian Yange , Zhang Lanxi , Zhao Peng , Li Jiansheng 
Published: September 2022

AbstractExercise training is the cornerstone component of pulmonary rehabilitation, which results in symptom‐reducing, psychosocial, and health economic benefits for chronic obstructive pulmonary disease (COPD) patients. However, the potential mechanisms of its action are poorly understood. This study conducted serum metabolomics using ultra‐high performance liquid chromatography–Q‐Exactive tandem mass spectrometry to determine the metabolic changes in COPD rats, and the effects of exercise training on improvement in COPD were further investigated. Twelve differential metabolites—which are primarily related to tryptophan metabolism, sphingolipid metabolism, glycerophospholipid metabolism, riboflavin metabolism, pantothenate and CoA biosynthesis, and lysine degradation—were identified in relation to COPD. After the intervention of exercise training, the levels of most metabolites were restored, and the changes in five metabolites were statistically significant, which suggested that exercise training provided effective protection against COPD and might play its role by rebalancing disordered metabolism pathways. This work enhanced our comprehension of the protective mechanism of exercise training on COPD.
Design, Synthesis, Antiviral Evaluation, and Molecular Dynamics Simulation Studies of New Spirocyclic Thiopyrimidinones as Anti HCoV‐229E
Authors: Ragab Sherif S. , Sweed Ayman M.K. , Elrashedy Ahmed A. , Allayeh Abdou K. 
Published: September 2022

AbstractThe current pandemic threat presented by viral pathogens like SARS‐CoV‐2 (COVID‐19) suggests that virus emergence and dissemination are not geographically confined. As a result, the quest for antiviral agents has become critical to control this pandemic. In the current study, we provide a novel family of spirocyclic thiopyrimidinone derivatives whose cytotoxicity and antiviral efficacy were investigated against human coronavirus 229E (HCoV‐229E) as a model for the Coronaviridae family. We utilized MTT and cytopathic effect (CPE) inhibitory tests on green monkey kidney (vero‐E6) cell lines. The new molecules showed varied degrees of antiviral activity against the vero‐E6 cell lines with minimal cytotoxicity. With a high level of a selective index (SI=14.8), compound 9 showed outstanding inhibitory ability and could effectively suppress the human coronavirus 229E. Molecular dynamics simulation (MD) studies were performed to measure the interaction and stability of the protein‐ligand complex in motion. The MD results for the most active compound 9 explored remarkable interactions with the binding pockets of the main protease (Mpro) of SARS‐CoV‐2 enzyme confirming the results gained from in vitro experiments. ADMET properties were also predicted for all the tested compounds. All these results demonstrated that the novel spirocyclic thiopyrimidinone derivatives would have the potential to be safe, low‐cost chemical compounds that might be used as a novel therapeutic option for Coronaviridae viruses like COVID‐19.
Montmorillonite K10 Clay Catalyzed Synthesis of Novel β‐Aminocarbonyl Compounds and Their Biological Evaluation
Authors: Rambabu Gottimukkala , Kiran Yarragudi Bathal Reddy , Tarakeswar Yadamari , Khalivulla Shaik Ibrahim , Barbosa Luiz Claudio Almeida , Vijayakumar Vijayaparthasarathi 
Published: September 2022

AbstractAn efficient and reusable green catalyst for the synthesis of β‐aminocarbonyl compounds has been developed. In this new and greener approach, β‐aminocarbonyl compounds (1a–1r) were obtained by Montmorillonite K10 clay catalyzed reaction of aryl amines, aliphatic/aromatic aldehydes and β‐ketoesters. Molecular docking investigations were performed for all compounds (1a–1r) with the proteins PDB ID: 1JIJ and 1KZN for S. aureus and E. coli, respectively. For all compounds good to strong interactions with the active sites were observed. The biological activities of β‐aminocarbonyl compounds were further assessed for their antibacterial and antioxidant activities. The results confirmed that β‐aminocarbonyl compounds could be further developed into new drugs with potent antibacterial and antioxidant activities.
Two New C21Steroidal Glycosides from Selaginella Braunii Baker
Authors: Li Gui‐Hua , Zhang Yan , Wu Jian‐Ping , Wang Yu‐Yan , Deng Gui‐Ming , Zeng Hong‐Liang , He Xiao‐Ai , Long Hong‐Ping , Zhu Gang‐Zhi , Chen Zu‐Hui , Cheng Fei , Xu Kang‐Ping 
Published: September 2022

AbstractTwo new C21 steroidal glycosides, brapreguanes A and B (1–2) were isolated from 75 % aqueous ethanol extract of Selaginella braunii Baker. Their structures were established by spectroscopic analyses (1D/2D NMR spectra and HR‐ESI‐MS). The absolute configurations of sugar were elucidated by enzymatic hydrolysis and GCMS analysis. In addition, all compounds were evaluated for the anti‐proliferative activities against various human cancer cells in vitro. Compounds exhibited no inhibition to various human cancer cells.
A comprehensive bioinformatic analysis revealed novel MicroRNA biomarkers of Parkinson's disease
Authors: Rahimpour Alireza , Heidarzadehpilehrood Roozbeh , Abdollahi Sepideh , Ranjbari Haidar , Shams Zinat , Ghasemi Seyed Abbas , Najmaei Shima , Pirhoushiaran Maryam 
Published: September 2022

AbstractParkinson's disease (PD) is categorized as a neurodegenerative disorder. Different studies have focused on the role of microRNAs (miRNAs) on PD progression. Due to its complexity in initiation and progression, a considerable requirement has arisen to identify novel miRNA biomarkers in a noninvasive manner. In silico analysis has been used to select differentially expressed miRNAs (DE‐miRNAs) and key pathways in this disease. In this manner, several data sets of different neurodegenerative diseases have been analyzed to purify the findings of the present study. Totally, 15 DE miRNAs showed significant changes compared to healthy controls and other neurodegenerative diseases. Then, the targets of the miRNAs were predicted through miRTarBase and TargetScan databases. Besides, enrichment analysis was implemented for predicted target genes. Most of the target genes were enriched in the TRAIL signaling pathway, Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism, protein serine/threonine kinase activity, and Cytoplasm. Moreover, a protein−protein interaction network was constructed to find the most key DE miRNAs and targets in this disease. The results of the present study may help researchers shed light on the discovery of novel biomarkers for PD.
False lumen patency status and outcomes after endovascular repair of uncomplicated chronic type B dissection
Authors: Kong Minjian , Ni Ming , Zhu Xian , Qian Jianfang , Duan Qunjun , Song Jiangwei , Feng Zhanzeng , Dong Aiqiang 
Published: September 2022

AbstractBackgroundThoracic endovascular aortic repair (TEVAR) remains a controversial treatment for uncomplicated chronic type B aortic dissection (cTBAD). This study was performed to investigate the postoperative outcomes of TEVAR, such as survival and reintervention, and the risk factors for prognoses.MethodsIn total, 41 patients with uncomplicated cTBAD who underwent TEVAR from 2014 to 2021 were reviewed. The patients were divided into two groups: those with false lumen complete thrombosis (FLCT) and false lumen partial thrombosis (FLPT) based on computed tomography angiography (CTA) images. Kaplan–Meier analysis was performed to estimate survival and freedom from reintervention. Binary logistic analysis was performed to estimate risk factors for partial thrombosis.ResultsDuring a mean follow‐up of 31 (1–78) months, five deaths and six reinterventions had occurred at 5 years. By 1 week, thoracic FLCT had occurred in 23 (56.1%) patients and thoracic FLPT had occurred in 18 (43.9%). The rate of freedom from reintervention was significantly lower in the FLCT than in the FLPT group (p = 0.04). The 5‐year survival rate of the two groups was not statistically significant (p = 0.14). Risk factors for thoracic FLPT were the distance between the re‐entry site and the graft (p = 0.02) and the proximal oversizing ratio (p = 0.04).ConclusionsTEVAR is an effective and safe treatment for uncomplicated cTBAD and has a low mortality rate. Thoracic FLCT is associated with less reintervention, but overall survival is not impacted by this difference. Patients treated with TEVAR without certain risk factors can have a good prognosis.
Antisynthetase Syndrome after chikungunya infection: A case report
Authors: Tuão Raiza Cansian , Macabú Mariana de Oliveira , Athayde Paula dos Santos , Moulaz Isac Ribeiro , Dalmaso Barbara Ferraço , Cristo Valéria Valim , Machado Ketty Lysie Libardi Lira 
Published: September 2022

AbstractChikungunya is an arboviral disease caused by a virus with wide geographical distribution in endemic areas. This case report documents a patient with antisynthetase syndrome post‐chikungunya infection. Autoimmune diseases result from breakdown of immune tolerance. Among all triggers, viruses represent the greatest environmental potential to precipitate inflammatory myopathy.
COVID‐19 vaccination and alopecia areata: a case report and literature review
Authors: Ganjei Zakiye , Yazdan Panah Mohammad , Rahmati Rahem , Zari Meidani Fatemeh , Mosavi Azam 
Published: September 2022

AbstractCoronavirus disease 2019 (COVID‐19) is a major concern worldwide and various vaccines have been developed and approved for it, however some immune‐related issues of COVID‐19 vaccines should be considered and individualized for patients. In this study we report two cases of rapidly progressive hair loss following COVID‐19 vaccination.
Phase Control of Lithium Silicates for Process‐Friendly Prelithiated SiO Anode Materials**
Authors: Bhat Asif , Sireesha Pedaballi , Chen Yue‐Sheng , Su Yu‐Sheng 
Published: September 2022

AbstractA low‐level metallic lithium thermal prelithiation strategy has been developed for boosting the performance of SiO anode materials with aqueous slurry processability. This facile prelithiation method can alter the phase and crystalline size of lithium silicates by controlling the parameters such as lithium contents and processing temperatures. The prelithiated graphene‐SiO composite anode material thus obtained under the optimized condition offers a high reversible capacity of 1062 mAh g−1 and the initial Coulombic efficiency of 80.8 %. Additionally, both the cycle life and cycling Coulombic efficiency are extremely stable, preserving over 90.3 % of the capacity after 200 cycles and more than 99.7 % of the efficiency on average during cycling. The significantly enhanced battery performance of the prelithiated SiO anode materials is owing to the size control of crystal silicon and Li2SiO3 phases. The existence of Li2Si2O5 and suppression of Li4SiO4 formation also guarantee homogeneous prelithiation results. This facile low‐level prelithiation approach is remarkably effective to improve the initial Coulombic efficiency for commercial SiO anode materials and simultaneously maintain superior reversible capacity, cycle life, cycling efficiency, and aqueous slurry processability.
Ermittlung der mechanischen Eigenschaften eines Silikondichtstoffs
Authors: Sitte Sigurd 
Published: September 2022

AbstractDie Kenntnis der mechanischen Dichtstoffeigenschaften ist erforderlich, um Verhalten und Leistungsfähigkeit wetterseitiger Dichtfugen zu beurteilen. Fassadeningenieure und Projektplaner sind oftmals daran interessiert, Dichtstoffe über die in technischen Datenblättern genannten Grenzen hinaus einzusetzen oder suchen nach verlässlichen Messergebnissen als Basis für detaillierte Berechnungen, z. B. mit Finite‐Element‐Methoden bei seismischer Belastung oder sehr großen Fassadenelementen. Zur korrekten Auslegung von Dichtfugen ist die Kenntnis der maximal zu erwartenden Fugenbewegungen sowie anderer Einflussfaktoren erforderlich (z. B. Bewitterung, Strahlung, Verschmutzung, Fassadenreinigungsmittel). Ein in Europa verbreiteter Silikondichtstoff für Fassaden ist DOWSIL™ 791. Da für diesen Dichtstoff bisher nur wenige Daten bekannt waren, wurde eine Untersuchung zur Ermittlung der mechanischen Eigenschaften gestartet. Durchgeführt wurden verschiedene Standardtests sowie Prüfungen spezieller Proben mit realen Fugengeometrien. Mit den Erkenntnissen können Dichtfugen ausgelegt und der Versagenspunkt bestimmt werden.Evaluation of mechanical properties for a weatherproofing silicone. The knowledge of mechanical sealant properties is mandatory to understand and predict behaviour and performance of weatherproofing joints. Facade engineering consultants and project planners regularly rise questions to understand, if weatherproofing sealants could be used in applications requiring higher movement capabilities than declared in technical datasheets or if measured data are available for advanced calculation methods such as finite element analysis. This can be required in case of seismic events, for very large pane sizes or high movements. To specify correctly sealant dimensions it is mandatory to know the maximum movements. Applied movements must be safely below the maximum capability of the sealant, considering many load cycles and long‐term ageing (e. g. weathering, sun radiation, facade cleaning products, dirt and air pollution). One of the most commonly used silicone weatherproofing sealant for facades in Europe is DOWSIL™ 791. Because only few data are available for this product, an evaluation has been performed and should help to understand better the mechanical properties and behaviour of this product. Both sample testing following to standardized test methods and specifically designed sample shapes illustrating the joint in its function were used. Using the results of this evaluation, weatherproofing joints can be dimensioned more safely and the failure point can be predicted.
Der Weg zur erfolgreichen baupraktischen Umsetzung von tragenden Silikonklebfugen in Deutschland
Authors: Baitinger Mascha , Wachter Nicolas , Teich Martien 
Published: September 2022

AbstractDie Anwendung der Klebtechnik im Glasfassadenbau erfordert bereits in frühen Projektphasen die sorgfältige Wahrnehmung von Planungsaufgaben und Abstimmung zwischen den Projektbeteiligten. Um Fehler zu vermeiden, bedarf es besonderer theoretischer und praktischer wie auch baurechtlicher Kenntnisse. Neben dem konstruktiven Entwurf sowie umfassender Berechnungs‐ und Bemessungsaufgaben nimmt die klebtechnische Ausführung und Qualitätssicherung eine entscheidende Rolle ein. Aktuelle Kenntnisse zur erfolgreichen Umsetzung tragender Silikonklebfugen finden sich im Merkblatt FKG 01/2021. Der folgende Artikel fasst die wichtigsten Punkte des Merkblatts zusammen, die es bei strukturellen Klebfugen konkret zu beachten gilt.Successful practical implementation of load‐bearing silicone adhesive joints in Germany. The application of adhesive bonding technology in glass facade construction requires the careful performance of planning tasks and coordination between the project participants already in the early project phases. In order to avoid mistakes, special theoretical and practical knowledge as well as knowledge of regulatory rules is required. In addition to the structural design, calculation methods and static dimensioning, adhesive bonding and quality assurance play a decisive role. Current knowledge on the successful implementation of load‐bearing silicone adhesive joints can be found in the Technical Note FKG 01/2021. The following article summarises the most important points of the Technical Note that must be specifically observed for structural adhesive joints.
Regiodivergent Asymmetric Pyridinium Additions: Mechanistic Insight and Synthetic Applications
Authors: Grigolo Thiago A. , Smith Joel M. 
Published: September 2022

AbstractA practical protocol for the first regiodivergent asymmetric addition of aryl and alkenyl organometallic reagents to substituted N‐alkyl pyridinium heterocycles is described. The couplings proceed with high regiochemical and stereochemical selectivities, and provide access to chiral 1,2,3‐ and 1,3,4‐trisubstituted dihydropyridine products, controlled by judicious choice of nitrogen activating agent. To this end, a correlation was found between the parameterized size of the activating group and the C2/C4 regioselectivity in the couplings. The utility of the described chemistry was demonstrated in two concise asymmetric syntheses of (+)‐N‐methylaspidospermidine and (−)‐paroxetine.
Overview on Grant Writing for Graduate Student Research
Authors: Smith Diane , Chowdhury Abu Sayeed , Oxford Julia Thom 
Published: September 2022

AbstractGrant writing is an important skill to develop during graduate school. This article provides an overview of grant writing for graduate students. Specific topics covered include understanding your funding needs, identifying appropriate grant opportunities, analyzing the guidelines for the proposal, planning and time management, understanding the priorities of the funding agency or organization, proposal organization and writing strategies, additional forms and letters of support that may be required, the editing and revising process, and submission of your grant proposal. Courses and workshops are an efficient and effective way to be guided through the grant proposal writing process with a greater potential for positive outcomes. © 2022 Wiley Periodicals LLC.
Thickness and yttria percentage influences the fracture resistance of laminate veneer zirconia restorations
Authors: Malallah Ali Dhahee , Hasan Nadia H. 
Published: September 2022

AbstractObjectivesMechanical properties are cardinal for the long‐term clinical success of laminate veneer restorations but the selection of new restorative materials should ideally be based on clinical evidence, therefore, in vitro testing of dental materials is a good alternative to evaluate their properties and understand their behavior so this study aimed to compare and evaluate the effect of two different thicknesses and yttria percentage on the fracture resistance of laminate veneer zirconia restorations.Materials and MethodsForty laminate veneer restoration prepared from partial sintering zirconia of 3Y (yttria), 5Y (yttria), combined 3Y&5Y (yttria), and lithium disilicate. Specimens were assigned into four main groups according to their percentage of yttria content (n = 10) and subgrouped into two thicknesses (0.5 mm thickness and 0.3 mm thickness) (n = 5) as follows: Group I, II, III, and IV (Group I for lithium disilicate (control), Group II for 3Y zirconia, Group III for 5Y zirconia, and Group IV for combined 3Y&5Y zirconia), each of them subdivided according to their thickness into two subgroups (n = 5 for each one) and resistance to fracture for each restoration was evaluated using a universal testing machine. Data were analyzed using a one‐way analysis of variance and Duncan's tests at a 5% level of significance.ResultsThe thickness of laminate veneer restoration significantly affects the fracture resistance value of all type of laminate veneers restorations (fracture resistance mean value was highest for 0.5 mm thickness and lower for 0.3 mm thickness restorations) and yttria percentage significantly affect fracture resistance value of zirconia laminate veneer restorations (fracture resistance mean value was highest for 0.5 mm thickness of 3Y zirconia [865 N] and combined 3Y&5Y zirconia [846 N]).ConclusionsReducing the thickness of laminate zirconia veneer restorations to 0.3 mm reduces its fracture resistance and increasing yttria percentage had an adverse effect on fracture resistance of zirconia laminate veneer restorations.