bluuebunny/crossref_metadata_2025_split huggingface dataset:
Steroid Receptor Coactivator 1 Promotes Human Hepatocellu-lar Carcinoma invasiveness Through Enhancing MMP-9
Authors: Tong Zhangwei , Zhang Yong , Guo Peng , Wang Wei , Chen Qiang , Jin Jing , Liu Shixiao , Yu Chundong , Mo Pingli , Zhang Lei , Huang Junli 
Published: December 2022

Abstract
Backgroud: SRC-1 works as a transcriptional coactivator for steroid receptors and other transcrip-tional factors. SRC-1 is shown to play oncogenic roles in many cancers, like breast cancer and prostate cancer. Our lab anteriorly accounted that SRC-1 is highly expressed in human HCC spec-imens. SRC-1 accelerates HCC progression via enhancing Wnt/beta-catenin signaling. However, the role of SRC-1 in HCC metastasis is unknown.
Methods: RNA inteference was used to knockdown the expression of SRC-1, and the protein level was detected via Western blot assay. Matrigel invasion assay was performed for assessment of HCC cell metastasis. MMP9 expression was detected via Zymography. Luciferase assays were performed to detect MMP-9 promoter activity.
Results: In this study, we report that SRC-1 promotes HCC metastasis through enhancing MMP-9 expression. Knockdown of SRC-1 decreased HCC cell metastasis in vitro and in vivo by inhibiting the expression of MMP-9. SRC-1 mRNA level is found to positively correlated with MMP-9 mRNA level in a limited number cohort of HCC specimens and a larger number cohort of HCC specimen from GEO database. SRC-1 functions as a coactiva-tor for NF-κB and AP-1 to regulate MMP-9 promoter activity in HCC cells. Higher SRC-1 and MMP-9 expression correlates with a worse overall survival in HCC patients. Bufalin treatment, which can inhibit SRC-1 expression, can significantly decreased MMP-9 expression and inhibit HCC metastasis both in vitro and in vivo.
Conclusion: Our results demonstrated that SRC-1 is a crucial modulator for HCC metastasis and offered a potential target for HCC therapy.
Calcium-Mediated DAD in Membrane Potentials and Triggered Activity in Atrial Myocytes of ETV1 f/f MyHC Cre/+ Mice
Authors: Fang Li-Hua , Cheng Xian-Lu , Chen Qian , Li Xiao-Qian , Zou Tian , Chen Jian-Quan , Xiang Guo-Jian , Li Yang , Zhang Jian-Cheng , Zhu Peng-Li 
Published: December 2022

Abstract
The E-twenty-six variant 1 (ETV1) -dependent transcriptome played an important role in atrial electrical and structural remodeling and the occurrence of atrial fibrillation，but the underlying mechenism of ETV1 in atrial fibrillation is unclear. In this study, cardiomyocyte-specific ETV1 knockout (ETV1f/fMyHCCre/+, ETV1-CKO) mice were constructed to observe the susceptibility to AF and the underlying mechanism in AF associated with ETV1-CKO mice. AF susceptibility was examined by intraesophageal burst pacing，induction of AF was increased obviously in ETV1-CKO mice than WT mice. Electrophysiology experiments indicated shortened APD50 and APD90, increased incidence of DADs, decreased density of ICa,L in ETV1-CKO mice. There was no difference in V1/2 INACT and V1/2 ACT, but a significantly longer duration of the recovery time after inactivation in the ETV1-CKO mice. The recording of intracellular Ca2+ showed that there was significantly increased in the frequency of calcium spark, Ca2+ transient amplitude, and proportion of SCaEs in ETV1-CKO mice. Reduction of Cav1.2 rather than NCX1 and SERCA2a, increase RyR2, p-RyR2 and CaMKII was reflected in ETV1-CKO group. This study demonstrates that the increase in calcium spark and SCaEs conresponding to Ca2+ transient amplitude that may trigger DAD in membrance potential in ETV1-CKO mice, thereby increasing the risk of AF.
Comparison of confidence among graduate teaching assistants before and after training
Authors: Peng Hexiang , Wu Yiqun , Zhou Ren , Chen Xi , Wang Mengying , Ren Tao , Yu Chihui , Wu Tao 
Published: December 2022

Abstract
Background: Teaching assistants (TAs) play an important role in pedagogical practices, and teaching assistant (TA) training has become a critical measure to promote teaching quality and interaction. TAs’ confidence might significantly increase the performance of TAs’ work. However, little evidence paid attention to the TAs’ confidence changes after TA training.
Methods: A self-control quasi-experiment was conducted to explore the TAs’ confidence changes before and after TA training. A qualified questionnaire was used to investigate the confidence of the graduate teaching assistants before and after the TA training.
Results: A total of 372 TAs from school of basic medicine (N=173), school of pharmacy (N=112), school of public Health (N=69) and other schools (N=18) submitted complete questionnaires. They had a median total confidence score of 88 and 85 before and after the TA training. The total TA confidence score decreased after TA training (P<0.001). For imparting new knowledge accurately to students, those who were disinterested in becoming a college teacher were associated with an increased confidence compared with neutral TAs (β:6.89, 95%CI: 0.94,12.83).
Conclusion: TA confidence decreased after TA training. Therefore, in addition to teaching skills training, it is necessary to establish and strengthen TAs’ confidence when designing TA training programs.
WormTensor: a clustering method for time-series whole-brain activity data from C. elegans
Authors: Tsuyuzaki Koki , Yamamoto Kentaro , Toyoshima Yu , Sato Hirofumi , Kanamori Manami , Teramoro Takayuki , Ishihara Takeshi , Iino Yuichi , Nikaido Itoshi 
Published: December 2022

Abstract
Background
In the field of neuroscience, neural modules and circuits that control biological functions have been found throughout entire neural networks. Correlations in neural activity can be used to identify such neural modules. Recent technological advances enable us to measure whole-brain neural activity with single-cell resolution in several species including Caenorhabditis elegans. Because current neural activity data in C. elegans contain many missing data points, it is necessary to merge results from as many animals as possible to obtain more reliable functional modules.
Results
In this work, we developed a new time-series clustering method, WormTensor, to identify functional modules using whole-brain activity data from C. elegans. WormTensor uses a distance measure, modified shape-based distance to account for the time delay and the mutual inhibition of cell-cell interactions and applies the tensor decomposition algorithm multi-view clustering based on matrix integration using the higher orthogonal iteration of tensors (HOOI) algorithm (MC-MI-HOOI), which can estimate both the weight to account for the reliability of data from each animal and the clusters that are common across animals.
Conclusions
We applied the method to 24 individual C. elegans and successfully found some known functional modules. Compared with a widely used consensus clustering method to aggregate multiple clustering results, WormTensor showed higher silhouette coefficients. Our simulation also showed that WormTensor is robust to contamination from noisy data. WormTensor is freely available as an R/CRAN package https://cran.r-project.org/web/packages/WormTensor.
Unconditional Stability and Fourth-Order Convergence Of A Two-Step Time Split Explicit/Implicit Scheme For Two-Dimensional Nonlinear Unsteady Convection-Diffusion-Reaction Equation With Variable Coefficients
Authors: Ngondiep Eric , Tedjani Ali H. 
Published: December 2022

Abstract
This paper deals with an efficient two-step time split explicit/implicit scheme applied to a two-dimensional nonlinear unsteady convection-diffusion-reaction equation with variable coefficients. The computational cost of the new algorithm at each time level is equivalent to solving a pentadiagonal matrix equation with strictly dominant diagonal elements. Such a bandwidth matrix can be easily inverted using the Gaussian Decomposition and the corresponding linear system should be solved by the back substitution method. The proposed approach is unconditionally stable, temporal second-order accuracy and fourth-order convergence in space. These results suggest that the developed technique is faster and more efficient than a large class of numerical methods studied in the literature for the considered initial-boundary value problem. Numerical experiments are carried out to confirm the theoretical analysis and to demonstrate the performance of the constructed numerical scheme.
Video-Based Tasks in Strengthening Speaking Skills of EFL College Students
Authors: Menggo Sebastianus , Basir Agnetis , Halum Yustus Sentus 
Published: December 2022

All teachers, including speaking instructors, should be able to select the proper interactive media for students' speaking practice. Video-assisted learning tasks in the speaking class have not been explored extensively, despite the reality that video-based tasks are an appropriate choice for students to enhance their speaking ability. This study sought to examine the Effect of video-based tasks on students' speaking skills. In this study, a quasi-experimental design was employed, and the speaking scoring rubric served as the research instrument. Both the experimental group and the control group were comprised of participants. Researchers gave pre-and post-tests to identify the impact of the video-based tasks technique on students' speaking skills. Using a simple random sampling technique, 56 students from the English study program in the first grade at Universitas Katolik Indonesia Santu Paulus Ruteng comprised the research sample; then, the data were analyzed by using a t-test with the assistance of the SPSS 24.0 program. The data analysis of the average student score in the experimental and control groups revealed that the experimental group's average score (80,29) was higher than the control group's average score (67,57). This result demonstrates the significant effects of video-based tasks in teaching speaking. The researchers concluded that video-based tasks were helpful for teaching speaking skills. Moreover, video-based tasks significantly impact students' ICT skills, learning independence, and self-evaluation development. The logical implication of this study's findings is that EFL teachers should use videos to teach English, particularly speaking skills, because it has been demonstrated to have a favorable effect on the respondents' speaking ability.
Understanding Frame on the Mindset of Orang Rimba Related to Pandemic Words
Authors: Rozelin Diana 
Published: December 2022

Understanding Frame on the Mindset of Orang Rimba Related to Pandemic Words Diana RozelinPostgraduate SchoolUIN Sulthan Thaha Saifuddin Jambi, Indonesiae-mail: dianarozelin@uinjambi.ac.id Abstract:During the Covid-19 pandemic, some terms appear to represent the coronavirus. For some people, Covid-19 terms were familiar, but not for others, such as Orang Rimba (OR). Some terms were weird and new because it was pronounced in the English language, such as 'social distancing', 'rapid test', and 'lockdown'. Meanwhile, the role of the government, in this case, BKSDA was very important to stop the spread of this virus within the OR community. This article not only talked about language but also the implementation of health. The purposes of this research were: 1) to find out the government's role through BKSDA in educating OR about Covid-19 terms and its preventing actions; 2) to find out the perception of OR toward the words of Covid-19. This research was conducted qualitatively. The technique for collecting the data was observation, interview, documentation, and recording. Meanwhile, for analyzing the data used descriptive techniques. The results were: 1) BKSDA office visited each OR group and gave directions and examples on how to wash hands, wear masks, keep their distance, and keep the environment clean. The suitable methods in teaching new things to OR are exemplary and habituation. 2) from 15 vocabulary words related to the Covid-19 pandemic, OR knew only 5 words. It was a mask, virus, washing hands, hand sanitizer, and corona. The word mask, according to OR, was a fabric for covering the nose and mouth. The meaning of the virus and corona were evil animals. The word washing hand means besuh tangon/ cuci tangon.
Hydroinformatics as a ‘game changer’ in the water business
Authors: Zeman E. , Metelka T. , Ingeduld P. , Shipton S. 
Published: December 2022

Abstract
This chapter presents the field of hydroinformatics as a game-changer in the water sector business. It reflects on Mike Abbott's original ideas and evaluates their impact from the perspective of water business owners, water consultants, clients, and communities. Mike Abbott promoted a novel concept, combining theoretical and practical aspects of modelling, towards ‘industrial modelling systems’. The chapter traces the development of this concept, from its early adoption by government-funded research institutes engaged in scientific support to hydraulic engineering, through establishment of market for water-modelling software products, to its broad adoption by consultants. Mike Abbott also saw a significant opportunity for hydroinformatics in the developing world. New policies and businesses were easier to implement in countries without a mature market of ideas resisting a change. Many of his followers were eager to explore business paths, which were much faster and more agile than those in academic circles. Most large companies that are currently developing commercial applications and tools for water modelling matured during the so-called ‘third modelling generation’, when generic modelling tools started to be developed. Subsequently, the real growth was observed when the knowledge encapsulation and robustness of the applications expanded their use from specialists to a broad pool of water professionals and practitioners. The social impact of hydroinformatics was significant as it spread through a wide range of organisations impacting decision making, education, innovation and knowledge sharing. As modelling systems became a norm in the water business, the business itself has been transformed. Impacts of current technologies and new data sources on water modelling business are presented (such as the Cloud, High Performance Computing - HPC, virtualisation, internet of things - IoT, remote sensing, and others), and how they impact current needs of software producers and users. Diverse business models have emerged, which need to meet the future challenges of urban and environmental water management under challenges of climate change. With the large and continuously growing community of modelling experts and users, it can be argued that the Mike Abbott's vision of hydroinformatics has been well established.
Hydroinformatics in China: overall developments and showcase of accomplishments in the Changjiang River basin
Authors: Huang Y. , Ba H. H. , Yu S. 
Published: December 2022

Abstract
Over the last few decades, China has experienced tremendous growth and socioeconomic development. This has also been a period of significant transformations in many social and economic sectors, including water management. Starting from revision of policies and regulatory frameworks, modifications of water engineering approaches have been introduced, together with broadening the overall management of river basins and water resources to encompass ecological and other nature services, next to considerations for economic benefits. These water management transformations have also been facilitated and enabled by introducing novel information and communication technologies, very much along the lines that Mike Abbott predicted and promoted as he was developing the field of hydroinformatics. In fact, he was always considering China as a country that would greatly benefit from hydroinformatics technologies as it has been going through rapid socioeconomic development, and, that the field itself would then make progress via novel Chinese applications. This chapter briefly introduces the main water management transformations and challenges that China has faced over the past few decades, and proceeds with presentation of hydroinformatics tools and technologies in the sequence of data→models→knowledge→decision-support applications, as they have been deployed in China. To showcase the use of such technologies in actual water management activities, the example of Changjiang River basin is presented as a case study, with demonstration of applications on flood management. These applications integrate monitored data with a suite of different models for flood forecasting and regulation of water infrastructure - particularly large scaled reservoir groups, where flood management is addressed in conjunction with other water resources functions. Decision support applications, such as to enable broader stakeholder and public participation - the platform serving for river/lake chief system - are also presented.
Logotherapy is effective in increasing self-esteem, but caution is needed: A meta-analytic study
Authors: Diadiningrum Jihan Rahma , Yudiarso Ananta 
Published: December 2022

Individuals with positive self-esteem recognize their personal qualities. They feel comfortable, optimistic, and confident about themselves. Conversely, individuals with negative self-esteem tend to experience poor quality of life. This study examines the effectiveness of logotherapy in increasing self-esteem. We conducted a meta-analysis by collecting and reviewing 14 research articles on logotherapy and self-esteem. We analyzed the data from the selected articles based on the number of participants (N), the average value (M), and the standard deviation (SD). The meta-analysis showed that logotherapy is a recommended and effective intervention to increase self-esteem.
Keywords: logotherapy, meta-analysis, self-esteem
Fishing Business Performance Analysis: An Entrepreneurial Approach
Authors: Rauf Rusdiaman , Wijaya Hengki 
Published: December 2022

AbstractEntrepreneurship requires work motivation, entrepreneurial learning and entrepreneurship commitment to improving business performance in various types of businesses, especially in the business activities of fishing communities. This study used a purposeful sample of 70 respondents and focused on fishermen who use boats as fishing equipment in the sea. The results of the study indicate that work motivation and commitment to entrepreneurship directly and partially have a significant positive effect on business performance, while entrepreneurial learning has an insignificant effect, while simultaneously work motivation, entrepreneurial learning and commitment to entrepreneurship have a positive and significant effect on business performance. Keywords: Work motivation, entrepreneurial learning, entrepreneurial commitment, business performance Analisis Kinerja Usaha Penangkapan Ikan:Suatu Pendekatan Kewirausahaan AbstrakKewirausahaan membutuhkan motivasi kerja, pembelajaran kewirausahaan dan komitmen kewirausahaan untuk meningkatkan kinerja usaha di berbagai jenis usaha, terutama dalam kegiatan usaha masyarakat nelayan. Metode penelitian ini dilakukan secara purposive pada nelayan yang memiliki perahu sebagai alat tangkap ikan di laut dengan jumlah sampel 70 responden. Hasil penelitian menunjukkan bahwa motivasi kerja dan komitmen berwirausaha secara langsung dan parsial berpengaruh positif signifikan terhadap kinerja usaha, sedangkan pembelajaran kewirausahaan berpengaruh tidak signifikan, sedangkan secara simultan motivasi kerja, pembelajaran kewirausahaan dan komitmen berwirausaha berpengaruh positif dan signifikan. pada kinerja usaha. Kata kunci: Motivasi kerja, pembelajaran wirausaha, komitmen wirausaha, kinerja usaha
PUBLIC PARTICIPATION IN REALIZING POLICY ACCOUNTABILITY COVID-19 PANDEMIC HANDLING AT YOGYAKARTA SPECIAL REGION
Authors: Ahdiyana Marita , Ulifah Nuri 
Published: December 2022

This study aims to describe community participation in realizing policy accountability for handling the covid-19 pandemic in the Special Region of Yogyakarta. The research design used was a descriptive study with a qualitative approach. Community participation was analyzed using a spectrum of five levels of participation. The results showed that community participation has manifested itself at every level of the spectrum of public participation. However, community participation is still limited to passive participation, where the community is only involved in policy implementation. At the information level, various information systems have been created to provide information, but not all of them can be accessed by the public. At consult level, various opinions from the community and stakeholders have received a good response and used as a consideration Governor. At the level of involvement, community has positioned as both a subject and an active participant in volunteering since the start of the pandemic. At the level of collaborate, collaboration has reached the stage of opening space for participation from various stakeholders. Last at the empower level, it has been carried out through various efforts. starting from the RT, RW, and Village levels. However, there has been no coordinated effort and clear division of roles in implementing the collaboration and empowerment.
Sample Bias in Web-Based Patient-Generated Health Data of Dutch Patients With Gastrointestinal Stromal Tumor: Survey Study
Authors: Dirkson Anne , den Hollander Dide , Verberne Suzan , Desar Ingrid , Husson Olga , van der Graaf Winette T A , Oosten Astrid , Reyners Anna K L , Steeghs Neeltje , van Loon Wouter , van Oortmerssen Gerard , Gelderblom Hans , Kraaij Wessel 
Published: December 2022

Background
Increasingly, social media is being recognized as a potential resource for patient-generated health data, for example, for pharmacovigilance. Although the representativeness of the web-based patient population is often noted as a concern, studies in this field are limited.

Objective
This study aimed to investigate the sample bias of patient-centered social media in Dutch patients with gastrointestinal stromal tumor (GIST).

Methods
A population-based survey was conducted in the Netherlands among 328 patients with GIST diagnosed 2-13 years ago to investigate their digital communication use with fellow patients. A logistic regression analysis was used to analyze clinical and demographic differences between forum users and nonusers.

Results
Overall, 17.9% (59/328) of survey respondents reported having contact with fellow patients via social media. Moreover, 78% (46/59) of forum users made use of GIST patient forums. We found no statistically significant differences for age, sex, socioeconomic status, and time since diagnosis between forum users (n=46) and nonusers (n=273). Patient forum users did differ significantly in (self-reported) treatment phase from nonusers (P=.001). Of the 46 forum users, only 2 (4%) were cured and not being monitored; 3 (7%) were on adjuvant, curative treatment; 19 (41%) were being monitored after adjuvant treatment; and 22 (48%) were on palliative treatment. In contrast, of the 273 patients who did not use disease-specific forums to communicate with fellow patients, 56 (20.5%) were cured and not being monitored, 31 (11.3%) were on curative treatment, 139 (50.9%) were being monitored after treatment, and 42 (15.3%) were on palliative treatment. The odds of being on a patient forum were 2.8 times as high for a patient who is being monitored compared with a patient that is considered cured. The odds of being on a patient forum were 1.9 times as high for patients who were on curative (adjuvant) treatment and 10 times as high for patients who were in the palliative phase compared with patients who were considered cured. Forum users also reported a lower level of social functioning (84.8 out of 100) than nonusers (93.8 out of 100; P=.008).

Conclusions
Forum users showed no particular bias on the most important demographic variables of age, sex, socioeconomic status, and time since diagnosis. This may reflect the narrowing digital divide. Overrepresentation and underrepresentation of patients with GIST in different treatment phases on social media should be taken into account when sourcing patient forums for patient-generated health data. A further investigation of the sample bias in other web-based patient populations is warranted.