bluuebunny/crossref_metadata_2025_split huggingface dataset:
REPRESENTAÇÕES SOCIAIS DE HOMENS IDOSOS SOBRE A COVID-19 E SENTIMENTOS GERADOS NO ISOLAMENTO SOCIAL
Authors: Rozendo Adriano , Isabel Giacomozzi Andréia , Barbará da Silva Bousfield Andréa , Leandro Maiara , Fiorott Juliana Gomes , Da Silveira Anderson 
Published: May 2022

Estudos apontam que os homens idosos são o grupo de maior risco de agravo e morte pela COVID-19, em decorrência de fatores biopsicossociais. As Representações Sociais (RS) possuem um papel importante nas práticas sociais pois orientam as ações de grupos. Nesse sentido, o presente estudo propôs-se a investigar as RS de homens idosos brasileiros sobre a COVID-19 de acordo com seu pertencimento grupal e sentimentos gerados pela pandemia. Para tanto, realizou-se um estudo de caráter exploratório-descritivo e comparativo lastreado pela TRS, com a participação de 102 homens. Os resultados apontaram para um possível núcleo central composto pelos elementos cuidados, medo e vírus. Ao comparar as RS de acordo com pertencimento grupal politico, observa-se RS polêmicas, pois o grupo de direita ainda que compreenda a necessidade de cuidados e tenha medo, possui incertezas sobre a doença, enquanto que os demais grupos trouxeram elementos mais ligados a prevenção. Por fim, os sentimentos de mal-estar, saudades, preocupações, resiliência e esperança foram os mais gerados nos idosos por conta da pandemia.
ПСИХОКОНСУЛЬТАТИВНА ВЗАЄМОДІЯ З ДЕЗАДАПТОВАНИМИ ПІДЛІТКАМИ У СИТУАЦІЇ РОЗЛУЧЕННЯ БАТЬКІВ
Authors: Герасіна С. , Хомич Г. 
Published: May 2022

У статті актуалізовано проблему порушення психосоціальної адаптації підлітків в умовах розлучення батьків. Розкрито вікові особливості і кризові тенденції формування підлітка. Досліджено психосоціальну дезадаптацію підлітків у комунікаціях з рідними, ровесниками і педагогами, у звичних їхніх справах і заняттях. Запропоновано психологічний супровід підлітка на засадах особистісно орієнтованого консультування у руслі тріадної взаємодії: «дитина – родина – школа».
Perancangan Sistem Informasi Akademik Berbasis Web di SMK YABP 1 Garut
Authors: Setiawan Ridwan , Agustin Yoga Handoko , Putuwenda Ditdit , Ramdani Dendi 
Published: May 2022

Sekolah Menengah Kejuruan (SMK) YABP 1 Garut merupakan lembaga pendidikan yang di mana pada saat ini kegiatan operasional pembelajaran, baik dalam administrasi, absensi, dan penilaian menggunakan sistem manual dalam kertas dan buku-buku induk data sehingga membutuhkan waktu yang cukup lama untuk melakukan kegiatan-kegiatan perekapan ataupun pengelolaannya sehingga dalam jangka waktu panjang akan menyebabkan penumpukan data karena jumlah data guru dan data siswa yang cukup banyak maka data yang ditampung akan semakin besar dan memperlambat kinerja untuk menyajikan informasi secara cepat dan tepat. Penelitian ini bertujuan untuk mengembangkan sistem informasi akademik yang meliputi data guru, data siswa, data kelas, jadwal kelas, dan nilai. Metodologi yang digunakan adalah Rational Unified Process dan pemodelan yang digunakan adalah Unified Modeling Language. Luaran dari penelitian ini adalah sistem informasi akademik sekolah SMK YABP 1 Garut berbasis web. Sistem informasi akademik berbasis web ini diharapkan dapat membantu memberikan informasi terkait data guru, data siswa, pendataan kelas, jadwal kelas dan nilai untuk pengajar, siswa, dan orang tua/wali siswa.
Los modelos administrativos en las PYMES del sector comercial de la ciudad de Machala
Authors: Sarango-Bermeo Magaly , Jaya-Pineda Iddar 
Published: May 2022

Los modelos administrativos aportan con el desarrollo de las empresas, al momento de adaptarlas a sus propias necesidades ocasionan que sea constante su incidencia en la productividad y servicios que ofrece, porque permite obtener la descripción total sobre cómo se manejan las funciones dentro y fuera de la misma, buscando obtener la satisfacción de la administración, colaboradores y consumidores (clientes), con la finalidad de tomar la mejor decisión empresarial debido a la flexibilidad de cada modelo. El objetivo de la investigación es identificar los modelos administrativos aplicados en las pequeñas y medianas empresas de la ciudad de Machala, la utilidad de aplicarlos. Se aplicó el método cualitativo- descriptivo, para conocer la importancia de contar con un modelo administrativo, conociendo los beneficios que estos otorgan y por medio de una encuesta aplicada a las 50 empresas seleccionadas mediante el muestreo por conveniencia que se encuentran registradas en la Superintendencia de Compañías, Valores y Seguros. Los resultados obtenidos demuestran que los modelos administrativos aportan al mejoramiento interno y externo de las empresas porque están basados en estrategias que permiten cumplir las normas de calidad en la prestación de sus productos o servicios mediante la constante innovación empresarial para lograr las ganancias económicas anheladas, por ende, son considerados de gran importancia por las Pymes dedicadas a la actividad comercial.
Palabras claves: modelos administrativos, toma de decisión, Pymes, estrategias, innovación empresarial
Efficient Production of Broad-Spectrum Antimicrobials by Paenibacillus polymyxa OSY–EC Using Acid Whey-Based Medium and Novel Antimicrobial Concentration Approach
Authors: Abdelhamid Ahmed G. , Campbell Emily P. , Hawkins Zach , Yousef Ahmed E. 
Published: May 2022

Production of some antimicrobial peptides by bacterial producers is a resource-intensive process, thus, using inexpensive growth media and simplifying antimicrobial extraction and down-stream processing are highly desirable. Acid whey, a dairy industry waste, is explored as a medium for production of broad–spectrum antimicrobials from selected bacteriocinogenic bacteria. Neutralized and yeast extract-supplemented acid whey was suitable for production of antimicrobials by four tested strains, but Paenibacillus polymyxa OSY–EC was the most prolific antimicrobial producer. Concentrating synthesized antimicrobials during culture incubation using beads of polymeric adsorbent resin, followed by solvent extraction and freeze-drying, resulted in antimicrobials-rich powder (AMRP). Under these conditions, P. polymyxa OSY–EC produced paenibacillin, polymyxin E, and fusaricidin, which are active against Gram-positive and Gram-negative bacteria and fungi, respectively. When media containing 2x and 4x minimum inhibitory concentrations of AMRP were inoculated with Listeria innocua and Escherichia coli, microbial populations decreased by ≥4–log CFU ml−1 in tryptic soy broth and ≥3.5–log CFU ml−1 in milk. The antimicrobial mechanism of action of AMRP solutions was attributed to the disruption of cytoplasmic membrane of indicator strains, L. innocua and E. coli. These findings exemplify promising strategies for valorization of acid whey via microbial bioreactions to yield potent antimicrobials.
Pan-Cancer Analysis, Reveals COVID-19-Related BSG as a Novel Marker for Treatment and Identification of Multiple Human Cancers
Authors: Huang Tao , He Wei-Ying 
Published: May 2022

Background: Coronavirus disease 2019 (COVID-19) has been a public threat and healthcare concern caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. During the period of the pandemic of COVID-19, cancer patients should be paid more attention as more severe events are found in cancer patients infected with SARS-CoV-2. Basigin (BSG) is an essential factor for the infection and progression of COVID-19 and tumorigenesis of multiple tumors, which may serve as a novel target for the effective treatment against COVID-19 and multiple human cancers.Methods: A total of 19,020 samples from multiple centers were included in our research for the comprehensive investigation of the differences in BSG expression among human organs, cancer cells, cancer tissues, and normal tissues. Cox regression analysis and Kaplan–Meier curves were utilized to explore the prognosis factor of BSG in cancers. Correlation analyses were used to determine associations of BSG expression with tumor mutational burden, the immune microenvironment, etc. Gene set enrichment analysis was applied to explore the underlying mechanisms of BSG in cancers.Results: Compared with normal tissues, BSG expression was high in 13 types of cancers (cholangiocarcinoma, etc.) and low in colon adenocarcinoma and rectum adenocarcinoma. BSG expression was related to the prognosis of eight cancers (e.g., invasive breast carcinoma) (p &lt; 0.05). The gene also demonstrated a pronounced effect in identifying 12 cancers (cholangiocarcinoma, etc.) from their control samples (AUC &gt;0.7). The BSG expression was associated with DNA methyltransferases, mismatch repair genes, immune infiltration levels, tumor mutational burden, microsatellite instability, neoantigen, and immune checkpoints, suggesting the potential of BSG as an exciting target for cancer treatment. BSG may play its role in several cancers by affecting several signaling pathways such as drug cytochrome metabolism P450 and JAK-STAT.Conclusion:BSG may be a novel biomarker for treating and identifying multiple human cancers.
Regional Strain Score as Prognostic Marker of Cardiovascular Events From the Multi-Ethnic Study of Atherosclerosis (MESA)
Authors: Pezel Theo , Bluemke David A. , Wu Colin O. , Lima João A. C. , Ambale Venkatesh Bharath 
Published: May 2022

BackgroundLeft ventricular (LV) circumferential strain (Ecc) is an accurate indicator of regional myocardial function, particularly using the regional Ecc or layer-specific strain.AimThis study aimed to investigate the prognostic value of a regional strain score (RSS) for predicting the incident of heart failure (HF) and coronary heart disease (CHD) in a population without a history of cardiovascular disease at baseline.Materials and MethodsData from participants in the Multi-Ethnic Study of Atherosclerosis (MESA) who underwent tagged magnetic resonance imaging for strain determination were analyzed. Using −17% and −10% as Ecc cut-offs, each segment was rated from 0 to 2 points according to the Ecc value of each layer. The endo-Ecc, mid-Ecc, and epi-Ecc values from the 16-segment model were used to calculate three RSS: Endo-, Mid-, and Epi-RSS, respectively, which were defined as a percentage of good LV regional function. The Intramyocardial-RSS was the sum of these three RSS. Cox proportional hazard models were used to evaluate the association between each RSS and incident HF and hard CHD.ResultsAmong the 1,506 participants (63.3 ± 9.4 years, 54.6% men), 122 cases of hard CHD and 91 cases of HF were observed [median (IQR) follow-up 15.9 (12.9–16.6) years]. After adjustment, Mid-, Epi-, and Intramyocardial-RSS values &lt;50% were independently associated with HF [adjusted HR 1.43; 95% CI (1.08–2.87), p = 0.004; HR 1.80; 95% CI (1.12–3.07), p &lt; 0.001; and HR 2.01; 95% CI (1.19–3.20), p &lt; 0.001]. After adjustment, Endo-, Mid-, Epi-, and Intramyocardial-RSS &lt;50% were also independently associated with hard CHD [adjusted HR 1.31; 95% CI (1.03–1.51), p = 0.04; HR 1.79; 95% CI (1.26–2.57), p &lt; 0.001; HR 2.03; 95% CI (1.45–3.40), p &lt; 0.001; and HR 2.28; 95% CI (1.51–3.53), p &lt; 0.001].ConclusionsLayer-specific regional Ecc, assessed by RSS, provides a robust, independent predictive value for incident HF and hard CHD in asymptomatic participants without any history of previous clinical cardiovascular disease.Clinical Trial RegistrationUnique identifier: NCT00005487.
A Landscape of Metabonomics for Intermingled Phlegm and Blood Stasis and Its Concurrent Syndromes in Stable Angina Pectoris of Coronary Heart Disease
Authors: Zheng Li , Mingxue Zhang , Zeng Li , Yushi Zhou , Yuhan Ao , Yi Yang , Botong Liu 
Published: May 2022

ObjectivesIn this study, we analyzed the metabonomics of intermingled phlegm and blood stasis (IPBS) and its three concurrent syndromes in patients with stable angina pectoris of coronary heart disease.MethodsA total of 164 sera of separated outpatients from 12 national tradition Chinese medicine clinical research centers with IPBS or concurrent syndromes were collected for the study and assessed with LC-ESI-MS/MS (liquid chromatography—electrospray ionization tandem—mass spectrometry)-based metabolomics and multivariate statistical analysis.ResultsNon-differential metabolites between IPBS and its separate syndrome combined with the top 100 most abundant metabolites in four groups were screened to reflect the essence of IPBS. Amino acid and its metabolomics and glycerol phospholipids were screened for common metabolites, and these metabolites were mainly enriched in valine, leucine, and isoleucine metabolism and glycerophospholipid metabolism. Principal component analysis revealed that the difference between IPBS and its separate concurrent syndromes was not distinct. Compared with IPBS, anserine, cytidine 5′-diphosphocholine, and 7,8-dihydro-L-biopterin separately significant increase in phlegm stasis and toxin (PST), phlegm stasis and Qi stagnation (PQS), and phlegm stasis and Qi deficiency (PQD). While these different metabolites were associated with histidine metabolism, beta-alanine metabolism, glycerophospholipid metabolism, and folate biosynthesis. Three accurate identification models were obtained to identify the difference between IPBS and its concurrent syndromes.ConclusionOur study indicated that valine, leucine, and isoleucine metabolism and glycerophospholipid metabolism could represent the essence of IPBS; dysregulated metabolites were valuable in identifying PST from IPBS.
Rupture Risk Assessment for Anterior Communicating Artery Aneurysms Using Decision Tree Modeling
Authors: Liu Jinjin , Xing Haixia , Chen Yongchun , Lin Boli , Zhou Jiafeng , Wan Jieqing , Pan Yaohua , Yang Yunjun , Zhao Bing 
Published: May 2022

BackgroundAlthough anterior communicating artery (ACoA) aneurysms have a higher risk of rupture than aneurysms in other locations, whether to treat unruptured ACoA aneurysms incidentally found is a dilemma because of treatment-related complications. Machine learning models have been widely used in the prediction of clinical medicine. In this study, we aimed to develop an easy-to-use decision tree model to assess the rupture risk of ACoA aneurysms.MethodsThis is a retrospective analysis of rupture risk for patients with ACoA aneurysms from two medical centers. Morphologic parameters of these aneurysms were measured and evaluated. Univariate analysis and multivariate logistic regression analysis were performed to investigate the risk factors of aneurysm rupture. A decision tree model was developed to assess the rupture risk of ACoA aneurysms based on significant risk factors.ResultsIn this study, 285 patients were included, among which 67 had unruptured aneurysms and 218 had ruptured aneurysms. Aneurysm irregularity and vessel angle were independent predictors of rupture of ACoA aneurysms. There were five features, including size ratio, aneurysm irregularity, flow angle, vessel angle, and aneurysm size, selected for decision tree modeling. The model provided a visual representation of a decision tree and achieved a good prediction performance with an area under the receiver operating characteristic curve of 0.864 in the training dataset and 0.787 in the test dataset.ConclusionThe decision tree model is a simple tool to assess the rupture risk of ACoA aneurysms and may be considered for treatment decision-making of unruptured intracranial aneurysms.
Evaluating the Association of Regional and City-Level Environmental Greenness and Land Over Patterns With PM2.5 Pollution: Evidence From the Shanxi Province, China
Authors: Guo Guangxing , Liu Liwen , Duan Yonghong 
Published: May 2022

Ambient PM2.5 (fine particulate matter with aerodynamic diameters ≤2.5 μm) is a major threat to human health. Environmental fates and human exposure to PM2.5 can be affected by various factors, and environmental greenness have been documented to be significantly associated with the exposure disparities; however, the relationship between the greenness and ambient PM2.5 on the region and city levels, and variations across different land cover types remain unclear. In this study, PM2.5 changes from 2001 to 2020 varying over different land cover types and cities were analyzed, and discussed for the relationships with environmental greenness, by taking Shanxi province as an example. The results showed in the past 2 decades, the mean annual NDVI (normalized difference vegetation index) of the study area showed a significant increasing trend (p &lt; 0.01), and the PM2.5 concentration decreased as environmental greenness get better. The same trends were observed across different land cover types and cities. The negative correlation was stronger in the construction land with more frequent human activities, especially in the built-up areas with low vegetation coverage; but limited in the high green space coverage areas. These results provide quantitative decision-making references for the rational development, utilization and management of land resources, but also achieving regional coordinated controls of PM2.5 pollution by optimizing land use.
SLC4A4, FRAS1, and SULT1A1 Genetic Variations Associated With Dabigatran Metabolism in a Healthy Chinese Population
Authors: Xie Qiufen , Li Yuan , Liu Zhiyan , Mu Guangyan , Zhang Hanxu , Zhou Shuang , Wang Zhe , Wang Zining , Jiang Jie , Li Xin , Xiang Qian , Cui Yimin 
Published: May 2022

Background: The purpose of this study was to identify genetic variations associated with the metabolism of dabigatran in healthy Chinese subjects, with particular focus given to pharmacokinetics (PK) and pharmacodynamics (PD).Methods: Healthy Chinese adults aged 18–65 years with unknown genotypes from a bioequivalence trial were included according to the protocol registered at ClinicalTrial.org (NCT03161496). All subjects received a single dose (150 mg) of dabigatran etexilate. PK (main outcomes: area under the concentration-time, AUC0-t, of total and free dabigatran) and PD (main outcomes: anti-FIIa activity, APTT, and PT) parameters were evaluated. Whole-exome sequencing and genome-wide association analyses were performed. Additionally, candidate gene association analyses related to dabigatran were conducted.Results: A total of 118 healthy Chinese subjects were enrolled in this study. According to the p-value suggestive threshold (1.0 × 10−4), the following three SNPs were found to be associated with the AUC0–t of total dabigatran: SLC4A4 SNP rs138389345 (p = 5.99 × 10−5), FRAS1 SNP rs6835769 (p = 6.88 × 10−5), and SULT1A1 SNP rs9282862 (p = 7.44 × 10−5). Furthermore, these SNPs were also found to have significant influences on the AUC0–t of free dabigatran, maximum plasma concentration, and anti-FIIa activity (p &lt; 0.05). Moreover, we identified 30 new potential SNPs of 13 reported candidate genes (ABCB1, ABCC2, ABCG2, CYP2B6, CYP1A2, CYP2C19, CYP3A5, CES1, SLCO1B1, SLC22A1, UGT1A1, UGT1A9, and UGT2B7) that were associated with drug metabolism.Conclusion: Genetic variations were indeed found to impact dabigatran metabolism in a population of healthy Chinese subjects. Further research is needed to explore the more detailed functions of these SNPs. Additionally, our results should be verified in studies that use larger sample sizes and investigate other ethnicities.
Prognostic Significance of PD-L1 Expression and Standardized Uptake Values in the Primary Lesions of Stage IV Adenocarcinoma Lung Cancer
Authors: Tien Cong Bui , Cam Phuong Pham , Thai Pham-Van , Thuong Vu-Le , Quang Hung Nguyen , Hang Dong-Thi , Anh Tuan Hoang , Minh Khuy Doan , Tuyen Pham-Van , Minh Duc Nguyen 
Published: May 2022

BackgroundThis study evaluated the prognostic ability of 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography (PET)/computed tomography (CT) in patients with stage IV adenocarcinoma lung cancer to detect protein death-ligand 1 (PD-L1) expression levels.MethodsIn total, 86 patients with stage IV adenocarcinoma lung cancer underwent 18F-FDG PET/CT imaging and PD-L1 expression evaluation before treatment from February 2019 to November 2020 at Bach Mai Hospital, Hanoi, Vietnam. The assessed patient characteristics in this study included sex, age, smoking status, epidermal growth factor receptor (EGFR) mutation, PD-L1 expression level, survival status, tumor, node, and metastasis (TNM) stage, and metastasis locations.ResultsThe average age was 62.23 ± 9.51 years, and men and women represented 67.4% and 32.6% of the population, respectively. The EGFR mutation rate was 36%. PD-L1 expression was negative (detected in &lt;1% of the tumor) in 40.7% of cases and positive in 59.3% of cases (detected in 1–49% of the tumor in 32.6%; detected in ≥50% of the tumor in 26.7%). The mean maximum standardized uptake value (SUVmax) was 11.09 ± 3.94. SUVmax was significantly higher in PD-L1–positive tumors than in PD-L1–negative tumors (12.24 ± 4.01 and 9.43 ± 3.22, respectively; p = 0.001). Receiver operating characteristic curve analysis revealed an area under the curve of SUVmax was 0.681 (95% confidence interval 0.570–0.793, p = 0.004). Compared with PD-L1–negative cases, SUVmax was significantly different in all PD-L1–positive cases (p = 0.001), weakly PD-L1–positive cases (1–49%, p = 0.005), and strongly PD-L1–positive cases (≥50%, p = 0.003). PD-L1 expression levels were significantly associated with SUVmax (p = 0.001), tumor size (p = 0.022), and EGFR mutation status (p = 0.045).ConclusionsSUVmax in the primary lesions was able to predict PD-L1 expression and may play a role in predicting PD-L1 immunotherapy efficacy in patients with stage IV lung adenocarcinoma.
A Highly Sensitive and Specific Detection Method for Mycobacterium tuberculosis Fluoroquinolone Resistance Mutations Utilizing the CRISPR-Cas13a System
Authors: Bai Xiaopeng , Gao Panqi , Qian Keli , Yang Jiandong , Deng Haijun , Fu Tiwei , Hu Yuan , Han Miaomiao , Zheng Huizhi , Cao Xiaoxia , Liu Yuliang , Lu Yaoqin , Huang Ailong , Long Quanxin 
Published: May 2022

ObjectivesCRISPR-Cas13a system-based nucleic acid detection methods are reported to have rapid and sensitive DNA detection. However, the screening strategy for crRNAs that enables CRISPR-Cas13a single-base resolution DNA detection of human pathogens remains unclear.MethodsA combined rational design and target mutation-anchoring CRISPR RNA (crRNA) screening strategy was proposed.ResultsA set of crRNAs was found to enable the CRISPR-Cas13 system to dramatically distinguish fluroquinolone resistance mutations in clinically isolated Mycobacterium tuberculosis strains from the highly homologous wild type, with a signal ratio ranging from 8.29 to 38.22 in different mutation sites. For the evaluation of clinical performance using genomic DNA from clinically isolated M. tuberculosis, the specificity and sensitivity were 100 and 91.4%, respectively, compared with culture-based phenotypic assays.ConclusionThese results demonstrated that the CRISPR-Cas13a system has potential for use in single nucleotide polymorphism (SNP) detection after tuning crRNAs. We believe this crRNA screening strategy will be used extensively for early drug resistance monitoring and guidance for clinical treatment.