bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dielectric properties and stratigraphy of regolith in the lunar South Pole-Aitken basin: Observations from the Lunar Penetrating Radar
Authors: Feng Jianqing , Siegler Matthew. A. , White Mackenzie N. 
Published: March 2022

Aims.We examine data obtained by the Lunar Penetrating Radar (LPR) onboard the Chang'E-4 (CE-4) mission to study the dielectric properties and stratigraphy of lunar regolith on the far side of the Moon.Methods.The data collected from January 2019 to September 2020 were processed to generate a 540 m radargram. The travel velocity of the radar signal and the permittivity of the regolith were deduced from hyperbolas in the radargram. As CE-4 LPR detected distinct planar reflectors, we evaluated the dielectric loss from the maximum penetration depth based on the radar equation. The derived dielectric properties are compared with the measurements of Apollo samples and Chang'E-2 microwave radiometer observations.Results.The results suggest that regolith at the landing site has a permittivity of 2.64–3.85 and a loss tangent of 0.0032–0.0044, indicating that the local regolith is composed of a fine-grained, low-loss material that is much more homogeneous than that found at the Chang’E-3 landing site. The total thickness of weathered material is ~40m, with several regolith layers and a buried crater identified in the reconstructed subsurface structure.Conclusions.These layers clearly record a series of impact events from the adjacent regions. We suggest that the top layer is primarily made up of the ejecta from a large crater 140 km away. In contrast, the material source of other thinner layers comes from nearby smaller craters.
When does mutualism offer a competitive advantage? A game-theoretic analysis of host–host competition in mutualism
Authors: Halloway Abdel H , Heath Katy D , McNickle Gordon G 
Published: March 2022

Abstract
Due to their non-motile nature, plants rely heavily on mutualistic interactions to obtain resources and carry out services. One key mutualism is the plant–microbial mutualism in which a plant trades away carbon to a microbial partner for nutrients like nitrogen and phosphorous. Plants show much variation in the use of this partnership from the individual level to entire lineages depending upon ecological, evolutionary and environmental context. We sought to determine how this context dependency could result in the promotion, exclusion or coexistence of the microbial mutualism by asking if and when the partnership provided a competitive advantage to the plant. To that end, we created a 2 × 2 evolutionary game in which plants could either be a mutualist and pair with a microbe or be a non-mutualist and forgo the partnership. Our model includes both frequency dependence and density dependence, which gives us the eco-evolutionary dynamics of mutualism evolution. As in all models, mutualism only evolved if it could offer a competitive advantage and its net benefit was positive. However, surprisingly the model reveals the possibility of coexistence between mutualist and non-mutualist genotypes due to competition between mutualists over the microbially obtained nutrient. Specifically, frequency dependence of host strategies can make the microbial symbiont less beneficial if the microbially derived resources are shared, a phenomenon that increasingly reduces the frequency of mutualism as the density of competitors increases. In essence, ecological competition can act as a hindrance to mutualism evolution. We go on to discuss basic experiments that can be done to test and falsify our hypotheses.
Modelling futility in the setting of fertility treatment
Authors: Polyakov Alex , Gyngel Christopher , Savulescu Julian 
Published: March 2022

Abstract
When is a fertility treatment futile? This question has great practical importance, given the role futility plays in ethical, legal and clinical discussions. Here, we outline a novel method of determining futility for IVF treatments. Our approach is distinctive for considering the economic value attached to the intended aim of IVF treatments, i.e. the birth of a child, rather than just the effects on prospective parents and the health system in general. We draw on the commonly used metric, quality-adjusted life years (QALYs), to attach a monetary value to new lives created through IVF. We then define futility as treatments in which the chance of achieving a live birth is so low that IVF is no longer a cost-effective intervention given the economic value of new births. This model indicates that IVF treatments in which the chance of a live birth are &lt;0.3% are futile. This suggests IVF becomes futile when women are aged between 47 and 49 years of age. This is notable older than ages currently considered as futile in an Australian context (∼45). In the UK, government subsidized treatment with the couple’s own gametes stops at the age of 42, while privately funded treatments are self-regulated by individual providers. In most European countries and the USA, the ‘age of futility’ is likewise managed by clinical consensus.
Vancomycin Is Effective in the Treatment of Chronic Inflammatory Conditions of the Pouch
Authors: Lupu Gabriel , Weaver Kimberly N , Herfarth Hans H , Barnes Edward L 
Published: March 2022

Lay Summary
In a retrospective analysis of the efficacy of vancomycin in treating chronic pouch-related disorders, we found that approximately half of patients demonstrated clinical response at 4 weeks. Additionally, 76% of responders continued to demonstrate clinical response at 3 and 6 months.
Ex machina: preliminary critical assessment of the European Draft Act on artificial intelligence
Authors: Raposo Vera Lúcia 
Published: March 2022

Abstract
This article will unpack the European Draft Act on Artificial Intelligence (AI), the first (both in Europe and in the world) far-reaching regulation in this domain. It categorizes AI systems in three (eventually four) levels of risk and it assigns to each level a particular legal framework, with its own limitations and obligations. The Draft Act was created for laudable purposes, namely to harmonize digital development with fundamental rights and European values. However, similar to many other ambitious projects, it falls short in many ways. As this article will show, several issues are incompletely regulated, and there are doubts about the exact scope and content of the legal solutions outlined in the draft. It also potentially overlaps with several other European norms, introducing the possibility of conflicts. Finally, the law’s focus on fundamental rights may come at the price of digital innovation, although critics claim that the Draft Act does not go far enough to protect such rights.
Dynamical Systems Around the Rauzy Gasket and Their Ergodic Properties
Authors: Dynnikov Ivan , Hubert Pascal , Skripchenko Alexandra 
Published: March 2022

AbstractAt the beginning of the 80s, H. Masur and W. Veech started the study of generic properties of interval exchange transformations (IETs) proving that almost every such transformation is uniquely ergodic. About the same time, S. Novikov’s school and French mathematicians independently discovered very intriguing phenomena for classes of measured foliations on surfaces and respective IETs. For instance, minimality is exceptional in these families. A precise version of this statement is a conjecture by Novikov. The French and Russian constructions are very different ones. Nevertheless, in the most simple situation (surfaces of genus three with two singularities) it was recently observed that both foliations share the same type of properties. For instance, the space of minimal parameters is the same, called the Rauzy gasket. However, the precise connection between these two series of works was rather unclear. The aim of this paper is to prove that both theories describe, in different languages, the same objects. This text provides an explicit dictionary between both constructions.
Strategies to Improve Racial and Ethnic Diversity in Breast Imaging Training and Beyond
Authors: Monga Natasha , Davis Katie M , Cardona-Del Valle Alejandra , Sieck Leah , DeBenedectis Carolynn M , Spalluto Lucy B 
Published: March 2022

Abstract
Diversity and inclusion in breast imaging can improve creativity and innovation, enrich the workplace environment, and enhance culturally appropriate care for an increasingly diverse patient population. Current estimates predict the racial and ethnic demographics of the United States population will change markedly by the year 2060, with increases in representation of the Black demographic projected to comprise 15% of the population (currently 13.3%) and the Hispanic/Latinx demographic projected to comprise 27.5% of the population (currently 17.8%). However, matriculation rates for those who are underrepresented in medicine (URM), defined as “racial and ethnic populations that are underrepresented in the medical profession relative to their numbers in the general population,” have remained largely stagnant. Black students comprise only 7.1% of medical student matriculants, and Hispanic/Latinx students comprise only 6.2% of medical school matriculants compared to the general population. The matriculation rate of URM students into diagnostic radiology is even lower, with Black trainees comprising 3.1% of radiology residents and Hispanic/Latinx trainees comprising 4.8% of radiology residents. This lack of URM radiology resident representation leads to a lack of URM potential applicants to breast imaging fellowships due to the pipeline effect. Strategies to improve diversity and inclusion in breast imaging include recruiting a diverse breast imaging workforce, establishing robust mentorship and sponsorship programs, fostering an inclusive training and workplace environment, and retaining and promoting a diverse workforce.
Tomography with sparseness regularisation for ultrasonic velocity imaging
Authors: Zhu Wei , Wang Shangxu , Chang Xu , Zhai Hongyu , He Taiming , Wu Hezhen 
Published: March 2022

Abstract
Ultrasonic tomography, which is widely used in the study of the fracturing process of rocks, often exhibits low resolution due to insufficient ray coverage, particularly while evaluating the three-dimensional (3D) fractures. To resolve this issue, we adopted sparseness regularisation in tomography to reconstruct the ultrasonic velocity of rocks. Both numerical and laboratory experiments demonstrate that tomography with sparseness regularisation generates velocity images with clear fracture morphology than that with Tikhonov regularisation. Dynamic monitoring of the fracturing process of a granite slab with two-dimensional (2D) velocity images can reveal the accurate development of the fracturing process. The experiment on the internal structure of tight sandstone after hydraulic fracturing reveals demarcated low-velocity regions in the 3D ultrasonic velocity images of tomography with sparseness regularisation. These low-velocity regions correspond to the positions of the fractures when compared to the X-ray scanning images. Thus, tomography with sparseness regularisation can improve the resolution of ultrasonic velocity images, which can be used to accurately describe the fracture development and strain localisation during rock deformation.
Superior performance of optimal perfectly matched layers for modeling wave propagation in elastic and poroelastic media
Authors: He Yanbin , Chen Tianning , Gao Jinghuai , Gao Zhaoqi 
Published: March 2022

Abstract
The perfectly matched layer (PML) technique is a popular truncation method to model wave propagation in unbounded elastic media. Both numerical efficiency and high stability are important improvement areas in the field. In this study, we extend the optimal PML, previously proposed for acoustic media, to elastic and poroelastic media, which turns out to be more efficient and flexible than the classical PML. We investigate the accuracy and stability of the optimal PML by comparing it with the classical PML in several scenarios. First, the effectiveness of the optimal PML is studied using frequency-domain and time-domain simulations for isotropic and homogeneous elastic solids. The efficiency and accuracy of the optimal PML and classical PML are then compared across a wide range of Poisson's ratios of elastic media. The stability of the optimal PML and the classical PML is also compared taking into account the effect of the outer boundary conditions of the PML as well as the heterogeneity of the geological model. Moreover, the optimal PML is applied to poroelastic media to address the instability problem of the classical PML. Comprehensive analyses of numerical results show that the optimal PML can absorb the outgoing waves. This can be done using thinner layers and with higher accuracy than for classical PMLs. In addition, the long-time stability of optimal PML increases.
When Agency Priorities Matter: Risk Aversion for Autonomy and Turf Protection in Mandated Collaboration
Authors: An Brian Y , Tang Shui-Yan 
Published: March 2022

AbstractMost studies in collaborative governance examine system-level or agency-level drivers of the horizontal dimension of collaboration, that is, the specific forms of collaboration among an existing set of actors. Few have examined the vertical dimension, that is, what actors are involved and the scope of collaboration. This study examines the latter issue by studying the implementation of the California Sustainable Groundwater Management Act (SGMA), passed in 2014, mandating collaboration among local agencies. We theorize that when their core mission and key constituencies’ interests are at stake under a mandate, agencies focus on protecting organizational autonomy and bureaucratic turf in determining the scope of the collaborative arrangement, rendering other usual collaboration drivers less relevant. With data derived from administrative records and a statewide survey of local groundwater managers, we test this argument using several analytical methods, including probit regression, two-step estimation of an ordered probit selection model, and a linear probability model. The analyses consistently show that agencies are more likely to commit to regionally integrated collaboration that matches the scale of a groundwater basin if (1) their mission addresses a broader issue focus (lower issue specificity), (2) their core stakeholder groups have less concentrated interests, and (3) the organizational culture is less rigid and risk averse. In contrast, other well-known horizontal collaboration drivers do not matter. By unpacking the agency-specific sources of turf and reputation protection, this study contributes to an understanding of collaboration risk management.
Biopharmaceutics studies applied to goyazensolide: a drug candidate from Lychnophora species
Authors: Tana Iara Dévula Tiso , Saúde-Guimarães Dênia Antunes , Caldeira Tamires Guedes , de Freitas Marques Maria Betânia , Mussel Wagner da Nova , de Souza Jacqueline 
Published: March 2022

Abstract

Objectives
To predict the substance’s behaviour in vivo and determine the viability of the bioactive substance to become a drug, this work aimed to evaluate the biopharmaceutics characteristics of goyazensolide.

Methods
Differential scanning calorimetry (DSC) and thermogravimetry (TG) were applied for the characterization of goyazensolide. The biopharmaceutics characteristics were evaluated using in-silico and in-vitro (shake-flask and Parallel Artificial Membrane Permeability Assay) methods.

Key findings
DSC curve showed a single endothermic peak. According to the TG curve, goyazensolide has thermal stability close to 221.0°C and 210.0°C, under a nitrogen and oxygen atmosphere, respectively. In-silico data indicated that goyazensolide has high solubility and low permeability. The high solubility was confirmed by equilibrium solubility studies determined by the shake-flask method. The dose/solubility ratio values were 175.16 ml (pH 1.2), 194.99 ml (pH 4.5) and 222.07 ml (pH 6.8). The effective permeability of 0.03 × 10−6 cm/s was obtained for goyazensolide. This value is lower than furosemide (1.03 × 10−6 cm/s), confirming the low permeability of goyazensolide.

Conclusions
Biopharmaceutics characteristics of goyazensolide are similar to drugs available on the market and attest to the feasibility of starting the process of developing a formulation containing this substance.
Granulomatosis with polyangiitis following Pfizer-BioNTech COVID-19 vaccination
Authors: Shirai Tsuyoshi , Suzuki Jun , Kuniyoshi Shimpei , Tanno Yuito , Fujii Hiroshi 
Published: March 2022

ABSTRACT
We report the first case of proteinase 3-antineutrophil cytoplasmic antibody-positive granulomatosis with polyangiitis (GPA) with predominant ears, nose, and throat manifestations following coronavirus disease 2019 (COVID-19) vaccination. A 63-year-old woman presented with aural fullness 3 days after vaccination. She presented with progressive rhinosinusitis and otitis media leading to profound hearing loss within 3 weeks. Clinical imaging revealed soft-tissue shadows in the paranasal sinuses with multiple pulmonary nodules, and histopathology was consistent with a diagnosis of GPA. It is crucial to be wary of the possibility of GPA in patients who received COVID-19 vaccines due to its rapid disease progression.
Systemic lupus erythematosus and antiphospholipid syndrome after COVID-19 vaccination. A case report
Authors: Molina-Rios Sebastian , Rojas-Martinez Rigoberto , Estévez-Ramirez Gloria Marcela , Medina Yimy Francisco 
Published: March 2022

ABSTRACT
Coronavirus disease 2019 (COVID-19) vaccines have some adverse effects, mostly mild. However, by presenting an immunological challenge to the individual, they could infrequently trigger immune-mediated diseases (IMDs). We report the case of a 42-year-old woman, with no previous medical history, who received the first dose of vaccine against COVID-19 and developed inflammatory arthralgias, associated with sudden-onset dyspnoea and hypoxemia. Pulmonary thromboembolism was documented, and the diagnosis of systemic lupus erythematosus (SLE) and secondary antiphospholipid syndrome (APS) was suspected. Autoantibodies were measured confirming this suspicion. After a few days, she presented a massive pericardial effusion with cardiac tamponade that required surgical management. Treatment with azathioprine, hydroxychloroquine, corticosteroids, and anticoagulation was indicated with improvement of all her symptoms. There is controversy regarding the potential of COVID-19 vaccines to induce autoimmunity. Studies addressing the safety of using these vaccines have reported the occurrence of mild local and systemic reactions, most frequently in young adults. So far, there are few reports of patients who have developed autoimmune or autoinflammatory diseases after getting vaccinated with any of the COVID-19 vaccines. To the best of our knowledge, to date, this is one of the first cases of new-onset SLE and secondary APS after COVID-19 vaccination.
Chromatin landscape associated with sexual differentiation in a UV sex determination system
Authors: Gueno Josselin , Borg Michael , Bourdareau Simon , Cossard Guillaume , Godfroy Olivier , Lipinska Agnieszka , Tirichine Leila , Cock J Mark , Coelho Susana M 
Published: March 2022

Abstract
In many eukaryotes, such as dioicous mosses and many algae, sex is determined by UV sex chromosomes and is expressed during the haploid phase of the life cycle. In these species, the male and female developmental programs are initiated by the presence of the U- or V-specific regions of the sex chromosomes but, as in XY and ZW systems, sexual differentiation is largely driven by autosomal sex-biased gene expression. The mechanisms underlying the regulation of sex-biased expression of genes during sexual differentiation remain elusive. Here, we investigated the extent and nature of epigenomic changes associated with UV sexual differentiation in the brown alga Ectocarpus, a model UV system. Six histone modifications were quantified in near-isogenic lines, leading to the identification of 16 chromatin signatures across the genome. Chromatin signatures correlated with levels of gene expression and histone PTMs changes in males versus females occurred preferentially at genes involved in sex-specific pathways. Despite the absence of chromosome scale dosage compensation and the fact that UV sex chromosomes recombine across most of their length, the chromatin landscape of these chromosomes was remarkably different to that of autosomes. Hotspots of evolutionary young genes in the pseudoautosomal regions appear to drive the exceptional chromatin features of UV sex chromosomes.
Genome-wide landscape of ApiAP2 transcription factors reveals a heterochromatin-associated regulatory network duringPlasmodium falciparumblood-stage development
Authors: Shang Xiaomin , Wang Changhong , Fan Yanting , Guo Gangqiang , Wang Fei , Zhao Yuemeng , Sheng Fei , Tang Jianxia , He Xiaoqin , Yu Xinyu , Zhang Meihua , Zhu Guoding , Yin Shigang , Mu Jianbing , Culleton Richard , Cao Jun , Jiang Mei , Zhang Qingfeng 
Published: March 2022

AbstractHeterochromatin-associated gene silencing controls multiple physiological processes in malaria parasites, however, little is known concerning the regulatory network and cis-acting sequences involved in the organization of heterochromatin and how they modulate heterochromatic gene expression. Based on systematic profiling of genome-wide occupancy of eighteen Apicomplexan AP2 transcription factors by ChIP-seq analysis, we identify and characterize eight heterochromatin-associated factors (PfAP2-HFs), which exhibit preferential enrichment within heterochromatic regions but with differential coverage profiles. Although these ApiAP2s target euchromatic gene loci via specific DNA motifs, they are likely integral components of heterochromatin independent of DNA motif recognition. Systematic knockout screenings of ApiAP2 factors coupled with RNA-seq transcriptomic profiling revealed three activators and three repressors of heterochromatic gene expression including four PfAP2-HFs. Notably, expression of virulence genes is either completely silenced or significantly reduced upon the depletion of PfAP2-HC. Integrated multi-omics analyses reveal autoregulation and feed-forward loops to be common features of the ApiAP2 regulatory network, in addition to the occurrence of dynamic interplay between local chromatin structure and ApiAP2s in transcriptional control. Collectively, this study provides a valuable resource describing the genome-wide landscape of the ApiAP2 family and insights into functional divergence and cooperation within this family during the blood-stage development of malaria parasites.
Retron reverse transcriptase termination and phage defense are dependent on host RNase H1
Authors: Palka Christina , Fishman Chloe B , Bhattarai-Kline Santi , Myers Samuel A , Shipman Seth L 
Published: March 2022

AbstractRetrons are bacterial retroelements that produce single-stranded, reverse-transcribed DNA (RT-DNA) that is a critical part of a newly discovered phage defense system. Short retron RT-DNAs are produced from larger, structured RNAs via a unique 2′-5′ initiation and a mechanism for precise termination that is not yet understood. Interestingly, retron reverse transcriptases (RTs) typically lack an RNase H domain and, therefore, depend on endogenous RNase H1 to remove RNA templates from RT-DNA. We find evidence for an expanded role of RNase H1 in the mechanism of RT-DNA termination, beyond the mere removal of RNA from RT-DNA:RNA hybrids. We show that endogenous RNase H1 determines the termination point of the retron RT-DNA, with differing effects across retron subtypes, and that these effects can be recapitulated using a reduced, in vitro system. We exclude mechanisms of termination that rely on steric effects of RNase H1 or RNA secondary structure and, instead, propose a model in which the tertiary structure of the single-stranded RT-DNA and remaining RNA template results in termination. Finally, we show that this mechanism affects cellular function, as retron-based phage defense is weaker in the absence of RNase H1.