bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Potential Prognostic, Diagnostic and Therapeutic Targets for Recurrent Arrhythmias
in Patients with Coronary Restenosis and Reocclusions After Coronary
Stenting
Authors: Li Xia , Guo Dianxuan , Zhou Wenhang , Hu Youdong , Zhou Hualan , Chen Ying 
Published: November 2022

Background:
The interplay of oxidative stress, proinflammatory microparticles, and proinflammatory cytokines in recurrent arrhythmias is unknown in elderly patients with coronary restenosis and reocclusions
after coronary stenting.

Objective:
This research sought to investigate the potential diagnostic and therapeutic targets for recurrent arrhythmias in patients with coronary restenosis and reocclusions after coronary stenting.

Methods:
We examined whether oxidative stress, proinflammatory microparticles, and proinflammatory cytokines could have effects that lead to recurrent arrhythmias in elderly patients with coronary restenosis and reocclusions. We measured the levels of malondialdehyde (MDA), CD31+
endothelial microparticle (CD31+
EMP), CD62E+
endothelial microparticle (CD62E+
EMP), high-sensitivity C-reactive protein (hs-CRP), interleukin-1β (IL-1β), interleukin-6 (IL-6), interleukin-8 (IL-8) and tumor necrosis factor-α (TNF-α), as well as
oxidized low-density lipoprotein (OX-LDL), and assessed the effects of relationship between oxidative stress,
proinflammatory microparticles, and proinflammatory cytokines on recurrent atrial and ventricular arrhythmias
in elderly patients with coronary restenosis and reocclusions after coronary stenting.

Results:
The levels of CD31+EMP, CD62E+EMP, MDA, hs-CRP, IL-1β, IL-6, IL-8, TNF-α and OX-LDL
were found to be increased significantly in coronary restenosis+recurrent atrial arrhythmia group compared to
without coronary restenosis and coronary restenosis+without recurrent atrial arrhythmia groups, respectively
(P<0.001). Patients in the coronary reocclusion+recurrent ventricular arrhythmia group also exhibited significantly increased levels of CD31+EMP, CD62E+EMP, MDA, hs-CRP, IL-1β, IL-6, IL-8, TNF-α and OX-LDL
compared to without coronary reocclusion and coronary reocclusion+without recurrent ventricular arrhythmia
groups, respectively (P<0.001).

Conclusion:
Proinflammatory microparticles, proinflammatory cytokines, and oxidative stress might act as potential targets for recurrent arrhythmias in patients with coronary restenosis and reocclusions after coronary
stenting.
Multiple Mutations on α, β and γ Domains of Streptokinase Lead to the
Generation of Highly Efficient Cysteine Analogues with Promising
Features
Authors: Mianroodi Reza Arabi , Alinodehi Narges Norouzzadeh , Behrooz Hamideh , Sabaei Milad , Nezamiha Farahnaz Khoshdel 
Published: November 2022

Background:
Streptokinase, one of the most widely used thrombolytic medicines, is a
favorable protein for site-specific PEGylation as it lacks any cysteine residues in its amino acid sequence;
however, any changes in the protein’s structure should be carefully planned to avoid undesired
changes in its function.

Objectives:
This study aimed to design and produce novel di/tri-cysteine variants of streptokinase
from previously developed cysteine analogues, Arg45, Glu263, and Arg319, as candidates for multiple
site-specific PEGylation.

Methods:
Using bioinformatics tools and site-directed mutagenesis, we incorporated concurrent mutations
at Arg45, Glu263, and Arg319 (carried out in our previous study) to create di/tri-cysteine
variants of streptokinase proteins (SK45-319cys, SK263-319cys, and SK45-263-319cys) and evaluated their kinetic
activity parameters by a colorimetric method, using H-D-Val-Leu-Lys-pNA.2HCl (S2251) as substrate.

Results:
Based on the kinetic results, SK263-319cys with 44% enzyme efficiency increment compared to
wild-type SK was the superior protein in terms of activity; as well, SK45-319cys and SK45-263-319cys
showed 17 and 22% activity enhancement, respectively. Docking of the mutant streptokinase proteins
with μ-plasmin demonstrated that changes in intermolecular interactions caused by amino acid
substitution could be the reason for activity difference.

Conclusion:
The novel mutant proteins created in this study exhibit remarkable biological activity
and may be uniquely suitable for simultaneous PEGylation on two/three domains. As well, PEGylated
derivates of these variants might prove to be more proficient proteins, compared to the singlecysteine
analogs of streptokinase; because of their more surface coverage and increased molecular
weight.
Prevalence, Distribution and Determinants of Obesity among South African Adults with Hypertension and Diabetes
Authors: Masilela Charity , Pearce Brendon , Ongole Joven Jebio , Johnson Rabia , Adeniyi Oladele Vincent , Benjeddou Mongi 
Published: November 2022

Background:
There is paucity of epidemiological data on the prevalence and determinants of obesity among South African adults with co-morbidities. This study therefore examined the prevalence, distribution, and determinants of obesity among South African adults with co-morbidities of hypertension and diabetes.

Methods:
A total of 614 South African adults attending chronic care for diabetes mellitus and hypertension were recruited. Obesity was defined as BMI ≥ 30.0kg/m2 and morbid obesity was defined as BMI ≥40 kg/m2. Multivariate logistic regression analysis was used to identify the significant determinants of obesity and morbid obesity.

Results:
Two-thirds of all participants were females [n = 461]. The overall prevalence of obesity among the study participants was 58.31%, of whom 15.15% were categorised as morbidly obese. In the multivariate logistic regression analysis, female sex [AOR=2.33; 95%CI 1.49-3.64], primary education [AOR=1.53, 95%CI 1.04-2.26], and LDL-C ≥2.6 mmol/L [AOR=0.64 95% CI 0.43-0.95] were independently associated with obesity. Also, women were almost six times more likely to be morbidly obese than men.

Conclusion:
A high prevalence of obesity attributed to sex, primary education and dyslipidaemia was found among the study participants. Aggressive and culturally sensitive obesity management and prevention strategies across the country need to be implemented to lower the incidence of cardiovascular diseases.
Screening Retinal Images and Extraction of the Retinal Blood Vessel for
Identifying Diseases and Classification of Arteries and Veins by Using
Deep Learning
Authors: Kumar K. Susheel , Yadav Shekhar , Pratap Singh Nagendra 
Published: November 2022

Abstract:
In recent years, the extraction of retinal blood vessels from low contrast retinal images
has become a challenging task for diagnosing retinal diseases such as Diabetic Retinopathy, Agerelated
Macular Degeneration (AMD), Retinopathy of Prematurity (ROP), cataract, and glaucoma.
Another challenge is screening the retinal image to identify the disease early on. However, data
analysis from a large population-based study of retinal diseases is required to help resolve the uncertainty
in identifying the retinal disease based on retinal image classification using deep learning approaches
from the retinal diseases dataset. Therefore, we proposed the survey on the deep learning
approach for screening the retinal image to identify the early stages of the disease and discussed
retinal disease analysis based on deep learning approaches to detect Diabetic Retinopathy, AMD
ROP, and Glaucoma. We also discuss deep learning applications in the segmentation of retinal
blood vessels, extraction of the optic disc, optic cup, and fovea, and OCT segmentation to detect
retinal disease for diagnosis of diseases. Finally, discuss the classification of arteries/veins using a
deep learning approach.
A Stepped Health Services Intervention to Improve Care for Mental and Neurological Diseases: Protocol for a Prospective Cohort Trial
Authors: Pollmanns Johannes , Großgarten Karlheinz , Wolff Julia K , Nolting Hans-Dieter , Graf Clarissa , Bergmann Frank , Nelles Gereon 
Published: November 2022

Background
Mental and neurological disorders cause a large proportion of morbidity burden and require adequate health care structures. However, deficits in the German health care system like long waiting times for access to specialized care and a lack of coordination between health care providers lead to suboptimal quality of care and elevated health care costs.

Objective
To overcome these deficits, we implement and evaluate a unique stepped and coordinated model of care (the Neurologisch-psychiatrische und psychotherapeutische Versorgung [NPPV] program) for patients with mental and neurological diseases.

Methods
Patients included in the program receive an appropriate treatment according to medical needs in a multiprofessional network of ambulatory health care providers. The therapy is coordinated by a managing physician and complemented by additional therapy modules, such as group therapy, internet-based cognitive behavioral therapy, and a case management. Statutory health insurance (SHI) routine data and data from a longitudinal patient survey will be used to compare the program with regular care and evaluate SHI expenditures and patient-related outcomes. A health care provider survey will evaluate the quality of structure and processes and provider satisfaction. Finally, an analysis of ambulatory claims data and drug prescription data will be used to evaluate if health care providers follow a needs-led approach in therapy. Ethics approval for this trial was obtained from the ethics committee of the chamber of physicians in North Rhine (September 13, 2017, reference No. 2017287).

Results
Patient enrollment of NPPV ended in September 2021. Data analysis has been completed in 2022. The results of this study will be disseminated through scientific publications, academic conferences, and a publicly available report to the German Federal Joint Committee, which is expected to be available in the first half of 2023.

Conclusions
The NPPV program is the first intervention to implement a stepped model of care for both mental and neurological diseases in Germany. The analysis of several data sources and a large sample size (more than 14,000 patients) enable a comprehensive evaluation of the NPPV program.

Trial Registration
German Clinical Trials Register DRKS00022754; https://tinyurl.com/3mx9pz5z.

International Registered Report Identifier (IRRID)
DERR1-10.2196/37569
The Assessment of Medical Device Software Supporting Health Care Services for Chronic Patients in a Tertiary Hospital: Overarching Study
Authors: Baltaxe Erik , Hsieh Hsin Wen , Roca Josep , Cano Isaac 
Published: November 2022

Background
Innovative digital health tools are increasingly being evaluated and, in some instances, integrated at scale into health systems. However, the applicability of assessment methodologies in real-life scenarios to demonstrate value generation and consequently foster sustainable adoption of digitally enabled health interventions has some bottlenecks.

Objective
We aimed to build on the process of premarket assessment of 4 digital health interventions piloted at the Hospital Clinic de Barcelona (HCB), as well as on the analysis of current medical device software regulations and postmarket surveillance in the European Union and United States in order to generate recommendations and lessons learnt for the sustainable adoption of digitally enabled health interventions.

Methods
Four digital health interventions involving prototypes were piloted at the HCB (studies 1-4). Cocreation and quality improvement methodologies were used to consolidate a pragmatic evaluation method to assess the perceived usability and satisfaction of end users (both patients and health care professionals) by means of the System Usability Scale and the Net Promoter Score, including general questions about satisfaction. Analyses of both medical software device regulations and postmarket surveillance in the European Union and United States (2017-2021) were performed. Finally, an overarching analysis on lessons learnt was conducted considering 4 domains (technical, clinical, usability, and cost), as well as differentiating among 3 different eHealth strategies (telehealth, integrated care, and digital therapeutics).

Results
Among the participant stakeholders, the System Usability Scale score was consistently higher in patients (studies 1, 2, 3, and 4: 78, 67, 56, and 76, respectively) than in health professionals (studies 2, 3, and 4: 52, 43, and 54, respectively). In general, use of the supporting digital health tools was recommended more by patients (studies 1, 2, 3, and 4: Net Promoter Scores of −3%, 31%, −21%, and 31%, respectively) than by professionals (studies 2, 3, and 4: Net Promoter Scores of −67%, 1%, and −80%, respectively). The overarching analysis resulted in pragmatic recommendations for the digital health evaluation domains and the eHealth strategies considered.

Conclusions
Lessons learnt on the digitalization of health resulted in practical recommendations that could contribute to future deployment experiences.
How to Use the Six-Step Digital Ethnography Framework to Develop Buyer Personas: The Case of Fan Fit
Authors: Fenton Alex , Heinze Aleksej , Osborne McVal , Ahmed Wasim 
Published: November 2022

Background
One of the key features of digital marketing is customer centricity, which can be applied to the domain of health. This is expressed through the ability to target specific customer segments with relevant content using appropriate channels and having data to track and understand each interaction. In order to do this, marketers create buyer personas based on a wide spectrum of quantitative and qualitative data. Digital ethnography is another established method for studying web-based communities. However, for practitioners, the complexity, rigor, and time associated with ethnographical work are sometimes out of reach.

Objective
This paper responds to the gaps in the practically focused method of using social media for digital ethnography to develop buyer personas. This paper aims to demonstrate how digital ethnography can be used as a way to create and refine buyer personas.

Methods
Using a case study of the Fan Fit smartphone app, which aimed to increase physical activity, a digital ethnography was applied to create a better understanding of customers and to create and refine buyer personas.

Results
We propose two buyer personas, and we develop a 6-step digital ethnography framework designed for the development of buyer personas.

Conclusions
The key contribution of this work is the proposal of a 6-step digital ethnography framework designed for the development of buyer personas. We highlight that the 6-step digital ethnography could be a robust tool for practitioners and academicians to analyze digital communications for the process of creating and updating data-driven buyer personas to create deeper insights into digital and health marketing efforts.
Comparative Analysis of Custard Produced from Selected Cereals (Guinea Corn, Maize, Rice and Millet)
Authors: Achimugu Solomon , Okolo Judith C. , Adaji Patricia E. 
Published: November 2022

This study looked at the proximate and organolleptic qualities of custard powder produced from four different cereals (guinea corn, maize, rice and millet). Proximate result ranged between 9.95-14.05%, 1.20-2.78%, 1.10-2.31%, 4.75-5.50%, 7.96-12.88% and 66.49-70.58% for moisture, ash, crude fiber, fat, protein and carbohydrate content respectively. There was significant difference in all the parameters evaluated. Product from guinea corn and Millet compared favourably with the product produced from the conventional cereal (maize). Also, sensory result revealed the preference of consumers for guinea corn and Millet based custard to the conventional primary raw material. The study established the superiority of custard from guinea corn and millet to that produced from maize.
Keywords Custard, Maize, Guinea corn, Rice, Millet
Characteristics of measles in children during the rise in incidence in 2019
Authors: Molochkova O. V. , Kovalev O. B. , Kosyreva M. A. , Ilyina N. O. , Shamsheva O. V. , Getmanova E. N. , Korsunsky A. A. , Galeeva E. V. , Guzhavina A. A. 
Published: November 2022

In Moscow, as in Russia, in 2019 there was an increase in the incidence of measles in recent years.Purpose: to analyze the course of measles in children hospitalized in 2019 during the period of rising incidence.Materials and methods: a retrospective analysis and statistical processing of 30 case histories of children hospitalized with measles in the infectious diseases department of the Children's City Clinical Hospital № 9 named after G.N. Speransky in 2019.Results: More than half of the patients were under the age of 3 years (53%). In 90% of cases, the sick were not vaccinated, in 73% – due to the refusal of their parents. Only 23% of patients had measles contact, mostly familial. Measles in hospitalized children proceeds typically, in 83.3% of cases in a moderate form, with characteristic pathognomonic symptoms: in 83.3% of patients, Belsky-Filatov-Koplik spots are detected, on average, on the 4.4 ± 0.8 day of illness, spotted – papular rash on the face with staged distribution and subsequent staged pigmentation in all patients. Complications develop in 66.7% of cases, more often pneumonia (36.7%) and obstructive bronchitis (20%), which in 16.7% of cases cause the severity of the course and lead to the development of emergency syndromes and conditions (respiratory failure, obstructive syndrome).Conclusions. Failure to vaccinate against measles contributes to morbidity with possible complications.
Detection of antibodies to <i>B. burgdorferi</i> by enzyme immunoassay in patients with Lyme borreliosis
Authors: Sayfullin R. F. , Zvereva N. N. , Saifullin М. А. , Smetanina S. V. , Kardonova E. V. , Shamsheva O. V. 
Published: November 2022

The detection of antibodies to borrelia by enzyme immunoassay (ELISA) significantly depends on the time from the onset of the disease.Purpose: analysis of the results of antibodies determination to borrelia by ELISA in children and adults with Lyme borreliosis (LB) at various periods from the onset of the disease.Material and methods. We conducted a retrospective, non-randomized, single-center cohort study, based on the analysis of data from 178 outpatient records of patients with a confirmed diagnosis of LB and the presence of antibody detection results by ELISA. Immunological confirmation of the diagnosis of LB was carried out by using ELISA and western blot test systems registered in the territory of the Russian Federation for the separate determination of immunoglobulins to Borrelia burgdorferi antigens of classes M and G. Results. When counting from the date of the onset of the disease, IgM and/or IgG were determined in 76% of patients at 4-6 weeks, and starting from the 7th week – in 95%. When counting from the date of tick bite, IgG with or without IgM was determined in 83% of patients starting from 7th week. At the same time, a significantly large proportion of seronegative patients among children was revealed. We have clarified the duration of antibody persistence after antibacterial therapy. In the interval from 1 to 6 months, antibodies are detected in 73% of patients. For a period of 6 months or more, antibodies can be detected in 42% of patients.Conclusion. The optimal time for detecting antibodies from the disease onset is 4-6 weeks. Antibodies after antibiotic therapy can persist for a long time, in a third of patients up to 6 months or more.
PENGARUH PROFITABILITAS, LEVERAGE, DAN UKURAN PERUSAHAAN TERHADAP NILAI PERUSAHAAN (Studi Kasus Pada Perusahaan Food And Beverage Yang Terdaftar Di Bursa Efek Indonesia)
Authors: Kusumaningrum Diyah Putri , Iswara Ulfah Setia 
Published: November 2022

Penelitian ini dilakukan bertujuan untuk menguji dan menganalisis variabel independen dan variabel dependen, yaitu variabel independen meliputi pengaruh profitabilitas, leverage, dan ukuran perusahaan terhadap nilai perusahan. Profitabilitas yang diukur dengan Return On Assets (ROA), leverage yang diukur dengan Debt To Equity Ratio (DER), dan ukuran perusahaan yang diukur dengan SIZE, selanjutnya variabel dependen yaitu nilai perusahaan diukur dengan Price Book Value (PBV). Sampel yang digunakan pada penelitian ini adalah perusahaan food and beverage yang terdaftar di Bursa Efek Indonesia (BEI) pada tahun 2017-2021. Jenis penelitian ini adalah penelitian kuantitatif. Teknik pengambilan sampel adalah purposive sampling. Berdasarkan kriteria-kriteria yang diperoleh dari sampel penelitian sebanyak 14 perusahaan sebagai sampel perusahaan dan diperoleh 70 data sebagai data observasi. Metode analisis yang dipergunakan dalam penelitian ini yaitu analisis linier berganda. Hasil penelitian menunjukan bahwa: (a) profitabilitas berpengaruh positif terhadap nilai perusahaan, artinya profitabilitas dalam perusahaan menjadi prospek yang baik untuk investor dimasa depan, (b) leverage berpengaruh positif terhadap nilai perusahaan, artinya leverage yang tinggi akan meningkatkan nilai perusahaan yang akan disukai oleh investor, dan (c) ukuran perusahaan tidak berpengaruh terhadap nilai perusahaan, artinya besar kecilnya perusahaan tidak bisa menjadi patokan profit dalam sebuah perusahaan.
Аналіз деяких методів розв'язання задачі розпізнавання дефектів на зображеннях
Authors: Роботишин М. В. , Маляр М. М. 
Published: November 2022

Задача розпізнавання дефектів користується широкою популярністю, особливо її застосування на індустріальних заводах, де об'єкти виготовляються десятками тисячами на день та можуть містити дефекти. Об'єкти з дефектами потрібно відділити від загальної маси об'єктів, для того щоб фінальний споживач отримав як найякісніший товар. Але перш ніж відділити дефектні об'єкти, їх потрібно знайти, отже розпізнати.
У даній роботі проаналізовано найпопулярніші методи для розв'язання задачі розпізнавання дефектів, коли вхідні дані є зображення. Розглянуто застосування як існуючих автоматизованих рішень, так і застосування методів на основі згорткових нейромереж, а саме нейронні мережі сегментації та детекції, які користуються широкою популярністю наразі. Проведено огляд даних методів та зроблено порівняльний аналіз різних класів методів на основі таких факторів як: вимоги до вхідних даних та вимоги до обчислювальних потужностей.
Про категорію зображень комутативної нециклічної напівгрупи третього порядку без одиничного і нульового елементів
Authors: Бондаренко В. М. , Зубарук О. В. 
Published: November 2022

Класифiкацiю напiвгрупи третього порядку (в термiнах таблиць Келi, з точнiстю до iзоморфiзму та антиiзоморфiзму) вперше отримав Т. Тамура в 1953 р., а згодом, але вже за допомогою комп’ютерної програми, Г. Е. Форсайт (1955 р.). Мiнiмальнi системи твiрних та вiдповiднi визначальнi спiввiдношення для всiх таких напiвгруп побудованi в працях В. М. Бондаренка i Я. В. Зацiхи. Вони також описали зображувальний тип напiвгруп третього порядку над довiльним полем i у вмпадку напiвгруп скiнченного зображувального типу вказали канонiчнi форми матричних зображень.
У низцi попереднiх праць автори вивчали категорнi властивостi напiвгруп малого порядку i, зокрема, дослiджували матричнi алгебри Ауслендера для напiвгруп тре-тього порядку. У цiй статтi продовжуються такi дослiдження.