bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mutations in LRP5 and BMP4 are associated with mesiodens, tooth agenesis, root malformation, and oral exostoses
Authors: Kantaputra Piranit Nik , Guven Yeliz , Tripuwabhrut Kanich , Adisornkanj Ploy , Hatsadaloi Athiwat , Kaewgahya Massupa , Olsen Bjorn , Ngamphiw Chumpol , Jatooratthawichot Peeranat , Tongsima Sissades , Ketudat Cairns James R. 
Published: June 2022

AbstractWNT/β‐catenin and BMP signaling pathways play important roles in the process of tooth development. Dysregulation of WNT/β‐catenin and BMP signaling is implicated in a number of human malformations, including dental anomalies. Whole exome and Sanger sequencing identified seven patients with LRP5 mutations (p.Asn1121Asp, p.Asp856Asn, p.Val1433Met, and p.Val1245Met) and six patients with BMP4 mutations (p.Asn150Lys, p.Gly168Arg, p.Arg269Gln, and p.Ala42Glu). All patients were affected with isolated dental anomalies (dental anomalies with no other structural defects), including mesiodens, tooth agenesis, unseparated roots, narrow roots, shortened and tapered roots, and taurodontism. Five patients with LRP5 and one with BMP4 mutations had oral exostoses. Protein models of LRP5 mutations indicate the possible functional effects of the mutations. Here we report for the first time that mutations in LRP5 are associated with dental anomalies. LRP5 appears to be the first gene related to pathogenesis of mesiodens. We also show for the first time that in addition to tooth agenesis, mutations in BMP4 are also implicated in root maldevelopment and torus mandibularis. Sharing of the phenotypes of the patients with LRP5 and BMP4 mutations, which include root maldevelopment, tooth agenesis, and torus mandibularis, implicates cross talks between the WNT/β‐catenin and BMP signaling pathways, especially during root development.
Correlation between chest CT severity scores and clinical and biochemical parameters of COVID‐19 pneumonia
Authors: Komurcuoglu Berna , Susam Seher , Batum Özgür , Turk Merve A. , Salik Bilge , Karadeniz Gulistan , Senol Gunes 
Published: June 2022

AbstractBackgroundThe COVID‐19 pandemic, which first appeared in Wuhan, China, in December 2019 and spread rapidly around the globe, continues to be a serious threat today. Rapid and accurate diagnostic methods are needed to identify, isolate and treat patients as soon as possible because of the rapid contagion of COVID‐19. In the present study, the relation of the semi‐quantitative scoring method with computed tomography in the diagnosis of COVID‐19 in determining the severity of the disease with clinical and laboratory parameters and survival of the patients were investigated along with its value in prognostic prediction.Material and methodA total of 277 adult patients who were followed up in the chest diseases clinic because of COVID‐19 pneumonia between 11.03.2020 and 31.05.2020 were evaluated retrospectively in the present study. Both lungs were divided into five regions in line with their anatomical structures, and semiquantitative radiological scoring was made between 0 and 25 points according to the distribution of lesions in each region. The relations between semiquantitative radiological score and age, gender, comorbidity, and clinical and laboratory parameters were examined.ResultsA significant correlation was detected between advanced age, lymphopenia, low oxygen saturation, high ferritin, D‐dimer, and radiological score in the univariate analysis performed in the present study. The cut‐off value of the semiquantitative radiology score was found to be 15 (AUC: 0.615, 95% CI: 0.554–0.617,p = 0.106) in ROC analysis. The survival was found to be better in cases with a radiology score below 15, in Kaplan–Meier analysis (HR: 4.71, 95% CI: 1.43–15.46,p < 0.01). In the radiological score and nonparametric correlation analyses, positive correlations were detected between CRP, D‐dimer, AST, LDH, ferritin, and pro‐BNP, and a negative correlation was found between partial oxygen pressure and oxygen saturation (p = 0.01,r = 0.321/0.313/0.362/0.343/0.313/0.333/−0.235/−0.231, respectively)ConclusionIt was found that the scoring system that was calculated quantitatively in thorax HRCTs in Covid‐19 patients is a predictive actor in determining the severity and prognosis of the disease in correlation with clinical and laboratory parameters. Considering patients who have a score of 15 and above with semiquantitative scoring risky in terms of poor prognosis and short survival and close follow‐up and early treatment may be effective to reduce mortality rates.
Cutaneous lupus‐erythematosus‐like reaction arising after COVID‐19 vaccination
Authors: Rose Colin , Apgar Ryan , Green Margaret 
Published: June 2022

AbstractMultiple adverse cutaneous reactions have been described following vaccination against COVID‐19. This case report describes a reaction to the Pfizer‐BioNTech (BNT162b2) vaccine that histopathologically resembles cutaneous lupus erythematosus with vacuolar interface alteration, superficial to mid‐dermal perivascular and periadnexal lymphocytic infiltrate with clusters of CD123+ cells, and mildly increased dermal mucin.
Hybrid closed‐loop therapy with a first‐generation system increases confidence and independence in diabetes management in youth with type 1 diabetes
Authors: Roberts Alison , Fried Leanne , Dart Julie , de Bock Martin , Fairchild Janice , King Bruce , Ambler Geoffrey R. , Cameron Fergus , McAuley Sybil A. , Keech Anthony C. , Jenkins Alicia , O′Neal David N. , Davis Elizabeth A. , Jones Timothy W. , Abraham Mary B. ,   for the Australian JDRF Closed Loop Research group
Published: June 2022

AbstractAimHybrid closed‐loop (HCL) therapy improves glycaemic control in adolescents with type 1 diabetes; however, little is known about their lived experience using these systems. The aim of this study was to explore the lived experiences of youth with type 1 diabetes using HCL therapy, and their parents, to provide insight into their lived experiences.MethodsAdolescents and young adults aged 12–25 years, who used Medtronic MiniMed™ 670G HCL system during a 6‐month randomised clinical trial, and their parents, were invited to participate in a semi‐structured interview at the end of the study. Open‐ended questions were used to explore the lived experiences of families using HCL. The interviews were audio‐recorded, transcribed and analysed using thematic analysis to determine the main themes.ResultsIn all, 17 young people with type 1 diabetes mean ± SD age: 17.5 ± 4.2 years, diabetes duration: 11.0 ± 4.9 years and HbA1c 64 ± 9 mmol/mol (8.0 ± 0.8%) and 10 parents were interviewed. Three themes were identified: (1) ‘Developing confidence and trust in the system’, (2) ‘Reduction in anxiety’ and (3) ‘Issues with device’. They reported a positive experience using HCL, with improvements in glucose levels and increased independence with diabetes management. However, frustration around the number of alarms and notifications associated with the system were also identified as issues.ConclusionBoth youth and parents acknowledged the benefits of this first‐generation HCL system in improving glycaemic outcomes and in providing flexibility and independence. These lived experiences provide valuable information in the introduction and provision of targeted education with HCL therapy.
University insiders' perceptions of doctoral education development in five East and Southeast Asian countries: An institutional logics perspective
Authors: Zhuang Tengteng , Liu Baocun , Ding Ruichang 
Published: June 2022

AbstractThis article reports on a study that analysed multiple logics behind the development of doctoral education in China, Japan, South Korea, Singapore and Thailand. The analysis focused on the development over the past two decades and general measures to ensure quality. Research materials analysed in this article consisted of semi‐structured interviews with insiders in the doctoral education system in each of the five countries. The findings reveal that the growth of the doctoral education sector in China follows state logic, profession logic and corporation logic. Doctoral education in Japan shows state logic, profession logic and market logic. State logic, market logic and corporation logic are manifested in South Korea's doctoral education sector, whereas state logic and profession logic are prominent in Singapore. Doctoral education in Thailand mostly follows state logic and market logic. Establishing and completing the external and internal quality mechanisms, tightening quality inspection procedures and raising requirements for students are common measures put in place for quality assurance throughout East and Southeast Asia.
Forecasting seizure clusters from chronic ambulatory electrocorticography
Authors: Ilyas Adeel , Hoffman Clarissa , Vakilna Yash , Chaliyeduth Sreekanth , Muhlhofer Wolfgang , Riley Kristen O. , Dabaghian Yuri , Lhatoo Samden D. , Pati Sandipan 
Published: June 2022

AbstractSeizure clusters are seizures that occur in rapid succession during periods of heightened seizure risk and are associated with substantial morbidity and sudden unexpected death in epilepsy. The objective of this feasibility study was to evaluate the performance of a novel seizure cluster forecasting algorithm. Chronic ambulatory electrocorticography recorded over an average of 38 months in 10 subjects with drug‐resistant epilepsies was analyzed pseudoprospectively by dividing data into training (first 85%) and validation periods. For each subject, the probability of seizure clustering, derived from the Kolmogorov–Smirnov statistic using a novel algorithm, was forecasted in the validation period using individualized autoregressive models that were optimized from training data. The primary outcome of this study was the mean absolute scaled error (MASE) of 1‐day horizon forecasts. From 10 subjects, 394 ± 142 (mean ± SD) electrocorticography‐based seizure events were extracted for analysis, representing a span of 38 ± 27 months of recording. MASE across all subjects was .74 ± .09, .78 ± .09, and .83 ± .07 at .5‐, 1‐, and 2‐day horizons. The feasibility study demonstrates that seizure clusters are quasiperiodic and can be forecasted to clinically meaningful horizons. Pending validation in larger cohorts, the forecasting approach described herein may herald chronotherapy during imminent heightened seizure vulnerability.
The Depths of Christ’s Love
Authors: Bae Hyunju 
Published: June 2022

AbstractThis article seeks to overcome the conventional separation between agape and eros and explores the full humanity and embodiment of Jesus Christ by focusing on his divine eros. When eros turns creative, sacramental, and prophetic, divine eros emerges. The story of the encounter between Jesus and the woman in Luke 7:36‐50 receives a fresh interpretation in light of the presence of divine eros. Divine eros is a manifestation of Jesus’ embodied radical love. Confronting unprecedented global challenges, the ecumenical movement is searching for new wineskins to unleash relational power at its diverse levels to rejuvenate itself. Lessons from Jesus’ art of loving might serve as a rich inspiration for those who desire to do justice to the sacred web of life and to love well as bridge‐building instruments of Christ’s love.
Given for Us
Authors: Ekué Amélé Adamavi‐Aho 
Published: June 2022

AbstractAgainst the background of the theme of the 11th Assembly of the World Council of Churches (WCC), “Christ’s love moves the world to reconciliation and unity,” this article explores the relevance of “gifts” and “giving” in the context of ecumenical relationships and the role that ethics play in these relationships. Giving, receiving, and giving back in turn are seen as important ethical indicators in three ways. First, in terms of cultural anthropology, they point to the diverse ways in which different cultures understand the human being. Second, gifts denote social structures, status, and how people relate to each other in a wider creative web of relationships. Third, the idea of the gift picks up the central theological concept of God’s grace, freely given. At the heart of the narrative of Jesus and the events of the cross and resurrection is the reconciling and liberating gift and giving of Jesus. Such a non‐sacrificial reading is central to the questions evoked by the theme for the WCC assembly, scheduled for August–September 2022 in Karlsruhe, Germany.
Emerging positions of German firms in the industrial internet of things: A global technological ecosystem perspective
Authors: Lechowski Grzegorz , Krzywdzinski Martin 
Published: June 2022

AbstractThe industrial internet of things (IIoT) has created entirely new inter‐firm competitive and collaborative dynamics that focus on the supply of digital infrastructures, services and platforms for industrial users. These dynamics typically involve machinery builders, information technology suppliers and traditional technology buyers from various asset‐intensive sectors. Given the global character of IIoT technology, transnationally relevant inter‐firm arrangements have emerged for which we still lack a conceptually grounded understanding. This study addresses this research gap from the German perspective by combining the concepts of global value chains and complex technical systems. Empirically, we develop a multiple case study of established German firms that have provided IIoT technologies in the domain of ‘smart manufacturing.’ We investigate the firms’ evolving positions within the multi‐layered IIoT stack and explore their technological dependency on global cloud‐infrastructure suppliers. Second, we put the case study into the context of the recent German industrial‐policy initiatives related to the discourse of ‘digital sovereignty’, which attempt to improve the positions of domestic actors vis‐à‐vis the multi‐national tech companies. Conceptually, this study offers the framework of global technological ecosystems as a new perspective on the transnational platform economy, which highlights the enabling character of global‐scale digital infrastructures and acknowledges active involvement of non‐firm actors in ecosystem governance.
On not ‘being there’: Making sense of the potent urge for physical proximity in transnational families at the outbreak of the COVID‐19 pandemic
Authors: Simola Anna , May Vanessa , Olakivi Antero , Wrede Sirpa 
Published: June 2022

AbstractThis paper investigates transnational families’ experiences of the COVID‐19 pandemic outbreak and the accompanying sudden and unexpected travel restrictions. Our data consist of written stories collected in April–June 2020 from migrants with ageing kin living in another country. For many respondents, the situation provoked an acutely felt urge for physical proximity with their families. By analysing their experiences of ‘not being there’, we seek to understand what exactly made the urge to ‘be there’ so forceful. Bringing into dialogue literature on transnational families with Jennifer Mason's recent theoretical work on affinities, we move the focus from families’ transnational caregiving practices to the potent connections between family members. We argue that this approach can open important avenues for future research on families—transnational or otherwise—because it sheds light on the multisensory and often ineffable charges between family members that serve to connect them.
Negotiating public service bargains in postrevolutionary times: The case of Iran's diplomatic corps
Authors: Beaud Guillaume 
Published: June 2022

AbstractNew political regimes stemming from revolutions eventually find themselves confronted with the imperative to build upper bureaucratic apparatuses geared towards facilitating regime stability. This article examines the process of “re‐bureaucratization” in the Islamic Republic of Iran, whereby institutions are designed and reworked over time to accommodate distinct features of the reshuffled bureaucratic elite initially incongruous in a deregulated revolutionary environment. Precisely, it examines state institutions established to recruit and train postrevolutionary Iranian diplomats following the purges of state bureaucracies. Relying on qualitative and quantitative data, the article shows how such institutions allowed to outstrip loyalty‐driven politico‐administrative arrangements that are essentially short‐sighted, as once their aim fulfilled—asserting regime elites' control over the state—, they channel policy‐making deficiency. Conversely, their very designs craft a “Public Service Bargain” that concomitantly fosters diplomats' loyalty, expertise, and representativeness—which, for to the revolutionary canon, commingles diplomats' plebeianization and provincialization—into stabilized institutional arrangements.
Understanding the Evolution of Groundwater‐Contaminant Plume Chemistry Emanating from Legacy Contaminant Sources: An Example from a Long‐Term Crude Oil Spill
Authors: Cozzarelli Isabelle M. , Baedecker Mary Jo , Mumford Adam C. , Jaeschke Jeanne B. , Spencer Tracey A. 
Published: June 2022

AbstractUnderstanding the evolution of plumes emanating from residual hydrocarbon contaminant sources requires evaluating how changes in source compositions over time cause changes in dissolved plume chemistry as residual sources age. This study investigates such changes at the site of a 1979 crude‐oil pipeline spill and is the first comprehensive look at groundwater chemistry associated with a residual hydrocarbon source zones in different stages of aging. The data show a direct relationship between concentrations of benzene and naphthalene in the residual oil and those measured in water samples collected below the oil. Groundwater associated with oil near the spill site had different chemical composition compared with water associated with oil that had spread downgradient from the spill zone, indicating a shift in biodegradation reactions. These results emphasize that source zone processes are spatially and temporally heterogeneous and should be accounted for in natural attenuation studies where residual source zones persist.
Simple biliary cysts of the liver can be lined by mucinous epithelium
Authors: Wong Newton A C S , Abdalkoddus Muhammad , Al‐Khafaji Nadeem , Roach Huw , Abbadi Reyad 
Published: June 2022

Aims & MethodsSimple biliary cysts of the liver are described to be lined by biliary epithelium and may be managed nonsurgically or by deroofing only. By contrast, its important differential diagnosis—mucinous cystic neoplasm (MCN)—is at least focally lined by mucinous epithelium, has malignant potential, and therefore should be resected. Following anecdotal observations in routine diagnostic practice, the following case series was assembled to confirm whether simple biliary cysts of the liver can be lined by mucinous epithelium. Detailed clinicoradiological review, including postoperative follow‐up, was also completed to assess whether the presence of mucinous epithelium had any associations, including a risk of hepatobiliary neoplasia.ResultsHistological review of 21 simple biliary cysts received as surgical specimens over a 3‐ year period confirmed an absence of ovarian‐like stroma in all cases. The lining epithelium of seven cysts showed focal supranuclear/apical mucin, as confirmed histochemically. Cysts with mucinous epithelium were generally larger and more often showed histological evidence of previous haemorrhage than cysts without this epithelium. There were no other statistically‐significant differences in clinicoradiological features between cysts with and without mucinous epithelium, including at postoperative radiological follow‐up.ConclusionsFocal mucinous epithelium can be present in at least one‐third of surgically‐managed, simple biliary cysts of the liver. Such epithelium may be metaplastic and should not be misinterpreted to indicate a diagnosis of MCN but, apart from this, appears to have no clinical significance. Ovarian‐like stroma may therefore be the only histological feature that reliably distinguishes MCN from simple biliary cyst.
OPENING THE FLOODGATES: PARTIAL AND GENERAL EQUILIBRIUM ADJUSTMENTS TO LABOR IMMIGRATION
Authors: Bratsberg Bernt , Moxnes Andreas , Raaum Oddbjørn , Ulltveit‐Moe Karen Helene 
Published: June 2022

AbstractWe investigate the impact of a large immigration shock on occupational wages. We develop a general equilibrium model where individuals sort into occupations and confront testable hypotheses with data. To identify the effect of the labor supply shock, we introduce a novel instrument that exploits that immigrants systematically sort into different occupations than natives. We study the immigration wave to Norway after the Eastern enlargement and find that immigration led to lower relative occupational wages. A quantification of the general equilibrium shows welfare effects of immigration close to zero for natives, but negative effects for the pre‐existing population of immigrants.
Nutritional value and potential bioactivities of Pacific oyster (Crassostrea gigas)
Authors: Negara Bertoka Fajar Surya Perwira , Mohibbullah Md. , Sohn Jae‐Hak , Kim Jin‐Soo , Choi Jae‐Suk 
Published: June 2022

SummaryGlobally, Pacific oysters (Crassostrea gigas) have a high market demand owing to their increased nutritional value. Crassostrea gigas can be a dietary source to meet the daily nutritional needs. Several studies have evaluated the nutritional value and bioactivity of C. gigas. However, a review of studies examining the nutritional value and bioactivity of C. gigas has not been previously performed. This study aimed to review the studies evaluating the nutritional value and bioactivities of C. gigas components using the Preferred Reporting Items for Systematic Reviews and Meta‐Analyses guidelines. The online databases Web of Science, ScienceDirect, MEDLINE and PubMed were searched to retrieve published studies on the nutritional value and bioactivity of C. gigas. Among the 37 studies obtained after filtering, the highest number of studies evaluated other bioactivities of C. gigas, followed by studies evaluating the antioxidant activity. This review examined the C. gigas components, including protein, moisture, glycogen, minerals, essential amino acids and fatty acids, which exerted beneficial effects on human health. Environmental conditions and cultivation techniques influenced the nutritional contents of C. gigas. The bioactive components of C. gigas exhibited antimicrobial, antioxidant, anti‐inflammatory, antitumor and anticancer, hepatoprotective, antihypertensive, hypoglycaemic, skin whitening, skin immunomodulatory, antiwrinkle, cholesterol‐lowering, antiaudiogenic seizure and probiotic activities. In conclusion, C. gigas has a high nutritional value and comprises various bioactive components. Thus, C. gigas can be a source of bioactive components and a functional food. However, most studies evaluating the bioactivity of C. gigas were performed in vitro.