bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Timely Open Communication for Patient Safety Project
Authors: Paterson Margo Lynn , Medves Jennifer , Dalgarno Nancy , O'Riordan Anne , Grigg Robyn 
Published: January 2022

Background: Concern is growing over increased numbers of adverse events experienced by patients when admitted to acute care hospitals in Canada due to breakdowns in communication. The purpose of the Timely Open Communication for Patient Safety (TOC) project was to create a culture of patient safety through enhanced interprofessional communication by developing resources for caregivers and patients. Methods and Findings: The research was framed by a mixed methods design that included pre- and post-surveys and focus groups, online educational modules, face-to-face activities, and the development of patient orientation materials. Three clinical sites participated in the study. The findings indicate that supporting healthcare teams to identify strengths, challenges, and future directions of communicating, clarifying roles, functioning, and collaborating, coupled with educational interventions that raise awareness of patient safety,may enhance patient safety. The study was limited by the absence of data regarding the incidence of adverse events during the research period. Conclusion: The data showed improvement in team members' perceptions of interprofessional collaborative practice within the participating Collaborative Learning Units (CLUs). If the CLU model of care is adopted within the healthcare system, the safety of patients/clients may improve.
Myeloid Sarcoma of the Bladder in a Patient with Chronic myelomonocytic Leukaemia
Authors: Smith Rebecca , Mohamed Bashir , Nettleton Jeremy 
Published: January 2022

Background Myeloid sarcoma is a rare extramedullary tumour of immature granulocytes, most commonly involving the skin, bone, lymph nodes, and soft tissue. It is usually associated with a diagnosis of relapsed or de novo acute myeloid leukaemia, acute lymphoblastic transformation of a myelodysplastic/myeloproliferative neoplasm, or can occur as isolated myeloid sarcoma. Case report A 66-year-old female with a 7-year history of stable chronic myelomonocytic leukaemia presents with urgency, frequency, dysuria symptoms, and without new constitutional symptoms. She is found to have atypical, multifocal lesions on the right posterolateral wall of the bladder with associated hydronephrosis. Pathology reveals the diagnosis as myeloid sarcoma; surprisingly, bone marrow evaluation does not show evidence of acute leukaemic transformation. Conclusions Myeloid sarcoma occurring in patients with chronic myelomonocytic leukaemia is extremely rare, and there are no cases reported in the English literature of these patients developing lesions in the bladder. The urological manifestations of an underlying haematological malignancy are best managed with a combination of systemic chemotherapy and allogeneic stem cell transplant, and in this case, the only surgical intervention required was ureteric stenting and tissue biopsy. Although rare, it is essential to consider alternative diagnoses when confronted with an atypical bladder tumour; failure to do so may result in patient harm by exposure to unnecessary intervention and delay to potentially curative treatment.
Unsupervised Character Recognition with Graphene Memristive Synapses
Authors: Walters Ben , Lammie Corey , Yang Shuangming , Jacob Mohan , Azghadi Mostafa Rahimi 
Published: January 2022

Memristive devices being applied in neuromorphic computing are
envisioned to significantly improve the power consumption and speed of
future computing platforms. The materials used to fabricate such devices
will play a significant role in their viability. Graphene is a promising
material, with superb electrical properties and the ability to be
produced sustainably. In this paper, we demonstrate that a fabricated
graphene-pentacene memristive device can be used as synapses within
Spiking Neural Networks (SNNs) to realise Spike Timing Dependent
Plasticity (STDP) for unsupervised learning in an efficient manner.
Specifically, we verify operation of two SNN architectures tasked for
single digit (0-9) classification: (i) a simple single-layer network,
where inputs are presented in 5x5 pixel resolution, and (ii) a larger
network capable of classifying the Modified National Institute of
Standards and Technology (MNIST) dataset, where inputs are presented in
28x28 pixel resolution. Final results demonstrate that for 100 output
neurons, after one training epoch, a test set accuracy of up to 86% can
be achieved, which is higher than prior art using the same number of
output neurons. We attribute this performance improvement to homeostatic
plasticity dynamics that we used to alter the threshold of neurons
during training. Our work presents the first investigation of the use of
green-fabricated graphene memristive devices to perform a complex
pattern classification task. This can pave the way for future research
in using graphene devices with memristive capabilities in neuromorphic
computing architectures. In favour of reproducible research, we make our
code and data publicly
available https://anonymous.4open.science/r/c69ab2e2-b672-4ebd-b266-987ee1fd65e7.
Root resorption in relation to a modified piezocision technique
Authors: Arana Juliana Gómez , Rey Diego , Ríos Héctor , Álvarez María Antonia , Cevidanes Lucia , Ruellas Antonio C. , Aristizábal Juan Fernando 
Published: January 2022

ABSTRACT

Objectives
To evaluate root resorption of lower incisors and canines quantitatively in a group of patients who underwent orthodontic treatment with piezocision and/or a collagen reinforcement technique with a fully resorbable three-dimensional (3D) collagen xenograft matrix compared with a control group.

Materials and Methods
The study sample of this secondary analysis consisted of 32 periodontally healthy patients with angle Class I malocclusion or mild Class II or III malocclusion and moderate irregularity index scores who underwent orthodontic treatment and had before (T0) and after treatment (T1) cone-beam computed tomography scans. Root resorption of lower incisors and canines was assessed quantitatively in the following four groups: the control group received orthodontic treatment without piezocision, experimental group 1 received orthodontic treatment with piezocision, experimental group 2 received orthodontic treatment with piezocision and a 3D collagen matrix, and experimental group 3 received orthodontic treatment with a 3D collagen matrix.

Results
An overall statistically significant decrease in root length from T0 to T1 for all groups was observed (P &lt; .05). However, there was no significant difference among the groups in the amount of root length decrease from T0 to T1.

Conclusions
Orthodontic treatment combined with piezocision does not increase the risk of root resorption of lower incisors and canines when compared with orthodontic treatment without acceleration techniques. More studies with larger samples should be undertaken to confirm these results.
Beliefs Around Hypoglycemia and Their Impacts on Hypoglycemia Outcomes in Individuals with Type 1 Diabetes and High Risks for Hypoglycemia Despite Using Advanced Diabetes Technologies
Authors: Lin Yu Kuei , Richardson Caroline R. , Dobrin Iulia , DeJonckheere Melissa J. , Mizokami-Stout Kara , Fetters Michael D. , Aikens James E. , Fisher Simon J. , Ye Wen , Pop-Busui Rodica 
Published: January 2022

OBJECTIVE
This study aimed to 1) identify the frequency of severe and level 2 hypoglycemia presenting in individuals with type 1 diabetes using continuous glucose monitoring systems (CGMs), including those with concomitant closed-loop insulin pumps, in a clinical practice setting and 2) evaluate the impact of beliefs around hypoglycemia in the development of severe and level 2 hypoglycemia in this population.

RESEARCH DESIGN AND METHODS
A cross-sectional survey study in adults with type 1 diabetes using CGMs &gt;6 months was conducted at a large tertiary academic center. Participant demographics, 6-month severe hypoglycemia history, hypoglycemia beliefs (with the Attitude to Awareness of Hypoglycemia questionnaire), and 4-week CGM glucose data were collected. Statistical analysis was performed to assess the presentation of severe and level 2 hypoglycemia and identify associated risk factors.

RESULTS
A total of 289 participants were recruited (including 257 participants with CGM data within the last 3 months). Of these, 25.6% experienced at least one severe hypoglycemic episode in the last 6 months, and 13.6% presented with ≥1% of time in level 2 hypoglycemia on CGMs. Reporting beliefs about prioritizing hyperglycemia avoidance was associated with severe hypoglycemia development (P &lt; 0.001), while having beliefs of minimal concerns for hypoglycemia was associated with spending ≥1% of time in level 2 hypoglycemia (P = 0.038).

CONCLUSIONS
Despite the use of advanced diabetes technologies, severe and level 2 hypoglycemia continues to occur in individuals with type 1 diabetes and high hypoglycemia risks. Human factors, including beliefs around hypoglycemia, may continue to impact the effectiveness of glucose self-management.
Association of Baseline HbA1c With Cardiovascular and Renal Outcomes: Analyses From DECLARE-TIMI 58
Authors: Cahn Avivit , Wiviott Stephen D. , Mosenzon Ofri , Goodrich Erica L. , Murphy Sabina A. , Yanuv Ilan , Rozenberg Aliza , Bhatt Deepak L. , Leiter Lawrence A. , McGuire Darren K. , Wilding John P.H. , Gause-Nilsson Ingrid A.M. , Langkilde Anna Maria , Sabatine Marc S. , Raz Itamar 
Published: January 2022

OBJECTIVE
Current guidelines recommend prescribing SGLT2 inhibitors to patients with type 2 diabetes and established or at high risk for atherosclerotic cardiovascular disease (ASCVD), irrespective of HbA1c levels. We studied the association of HbA1c with cardiovascular and renal outcomes and whether the benefit of dapagliflozin varies by baseline HbA1c.

RESEARCH DESIGN AND METHODS
In the Dapagliflozin Effect on Cardiovascular Events trial (DECLARE-TIMI 58), 17,160 patients with type 2 diabetes were randomly assigned to dapagliflozin or placebo for a median follow-up of 4.2 years. Cardiovascular and renal outcomes by baseline HbA1c in the overall population and with dapagliflozin versus placebo in HbA1c subgroups were studied by Cox regression models.

RESULTS
In the overall population, higher baseline HbA1c was associated with a higher risk of cardiovascular death or hospitalization for heart failure (HHF); major adverse cardiovascular events (MACE), including cardiovascular death, myocardial infarction, and ischemic stroke; and cardiorenal outcomes (adjusted hazard ratios 1.12 [95% CI 1.06–1.19], 1.08 [1.04–1.13], and 1.17 [1.11–1.24] per 1% higher level, respectively). Elevated HbA1c was associated with a greater increased risk for MACE and cardiorenal outcomes in patients with multiple risk factors (MRF) than in established ASCVD (P-interaction = 0.0064 and 0.0093, respectively). Compared with placebo, dapagliflozin decreased the risk of cardiovascular death/HHF, HHF, and cardiorenal outcomes, with no heterogeneity by baseline HbA1c (P-interaction &gt; 0.05).

CONCLUSIONS
Higher HbA1c levels were associated with greater cardiovascular and renal risk, particularly in the MRF population, yet the benefits of dapagliflozin were observed in all subgroups irrespective of baseline HbA1c, including patients with HbA1c &lt;7%.
Cost-Related Medication Nonadherence in Adults With Diabetes in the United States: The National Health Interview Survey 2013–2018
Authors: Taha Mohamad B. , Valero-Elizondo Javier , Yahya Tamer , Caraballo César , Khera Rohan , Patel Kershaw V. , Ali Hyeon Ju R. , Sharma Garima , Mossialos Elias , Cainzos-Achirica Miguel , Nasir Khurram 
Published: January 2022

OBJECTIVE
Health-related expenditures resulting from diabetes are rising in the U.S. Medication nonadherence is associated with worse health outcomes among adults with diabetes. We sought to examine the extent of reported cost-related medication nonadherence (CRN) in individuals with diabetes in the U.S.

RESEARCH DESIGN AND METHODS
We studied adults age ≥18 years with self-reported diabetes from the National Health Interview Survey (NHIS) (2013–2018), a U.S. nationally representative survey. Adults reporting skipping doses, taking less medication, or delaying filling a prescription to save money in the past year were considered to have experienced CRN. The weighted prevalence of CRN was estimated overall and by age subgroups (&lt;65 and ≥65 years). Logistic regression was used to identify sociodemographic characteristics independently associated with CRN.

RESULTS
Of the 20,326 NHIS participants with diabetes, 17.6% (weighted 2.3 million) of those age &lt;65 years reported CRN, compared with 6.9% (weighted 0.7 million) among those age ≥65 years. Financial hardship from medical bills, lack of insurance, low income, high comorbidity burden, and female sex were independently associated with CRN across age groups. Lack of insurance, duration of diabetes, current smoking, hypertension, and hypercholesterolemia were associated with higher odds of reporting CRN among the nonelderly but not among the elderly. Among the elderly, insulin use significantly increased the odds of reporting CRN (odds ratio 1.51; 95% CI 1.18, 1.92).

CONCLUSIONS
In the U.S., one in six nonelderly and one in 14 elderly adults with diabetes reported CRN. Removing financial barriers to accessing medications may improve medication adherence among these patients, with the potential to improve their outcomes.
epistemologia implícita das práticas de ensino da matemática
Authors: Wichnoski Paulo , Ag Almouloud Saddo 
Published: January 2022

Os autores apresentam respostas à seguinte questão: O que é fazer matemáticas? Para quem ensinar matemáticas no dia a dia, essa questão pode parecer um luxo, até mesmo um jogo um tanto livre e sem muito interesse.
Imaging and diagnostic accuracy of outpatient and inpatient hysteroscopy
Authors: Frolova Yu. S. , Yelgina S. I. 
Published: January 2022

Aim. To compare the results of visualisation and diagnostic accuracy during outpatient and inpatient hysteroscopy in women with endometrial disease.Materials and Methods. We performed a retrospective analysis of patients with uterine diseases who underwent outpatient hysteroscopy at Kemerovo City Clinical Hospital №4 (n = 300) or inpatient hysteroscopy within the hospitals (n = 300) in Kemerovo from 2018 to 2020. Confirmation of endometrial disease was carried out by manual vacuum aspiration.Results. Indications, imaging, and diagnostic accuracy did not differ for most endometrial diseases in outpatient and inpatient hysteroscopy, yet inpatient hysteroscopy was the option of choice in women with infertility (p = 0.035). Diagnostic accuracy of outpatient and inpatient hysteroscopy was highly concordant, albeit outpatient hysteroscopy more often revealed adenomyosis and uterine malformation and less often identified endometrial polyps.Conclusion. Outpatient and inpatient hysteroscopy are equally efficient, although outpatient hysteroscopy has its benefits in detecting adenomyosis and uterine malformation and be less informative in diagnosing endometrial polyps.
Cetrimonium Surfactants with Biologically Active Counter Ions as Self-Immolative Drug Delivery Systems
Authors: Shah Syed Waqar Hussain , Bibi Iram , Yousaf Sabat 
Published: January 2022

Novel derivatives of cationic surfactant cetyltrimethylammonium bromide (CTAB) possessing anions of ibuprofen and naproxen as hydrophobic counterions were synthesized and characterized using Fourier transform infrared and differential electronic absorption spectroscopy. The self-assembly of each surfactant was investigated using surface tensiometry. The self-immolative nature of these compounds was analyzed through study of their behavior in response to trigger such as medium pH. ADMET-SAR (adsorption, distribution, metabolism, excretion, toxicity – structure-activity relationship) profiles of synthesized surfactants were generated using admetSAR v. 1.0). The cetrimonium drugs exhibited better profiles than the corresponding pure drugs, save the aqueous solubility which was reduced due to hydrophobicity of counterions.
Genetic Variation Analysis between Wild and Cultured Pangasianodon hypopthalmus Using COI and Cytochrome b Among Asian Countries
Authors: R Azmi Nik Azwarina , Ahmad Lyena Watty Zuraine , Kambol Roziah , Syed Mohamad Sharifah Aminah , Aris Farizan , Zakaria Nurul Aili , Mohamed Yunus Norfatimah 
Published: January 2022

One of the top species in the aquaculture sector, known as striped catfish or Pangasianodon hypophthalmus, is an important and valuable freshwater fish in many countries. Due to the high demand for this species, their number has declined to "threatened" levels. Hence, the purpose of this study is to analyse the genetic variation of wild and cultured striped catfish collected from five producers in Asian countries; Thailand, Vietnam, Indonesia, India, and Philippines, by using mitochondrial DNA partial region data sequence; CO1 and cytochrome b gene. Population analyses using 395 base pairs length for CO1 and 275 base pairs length of cytochrome b partial region nucleotide sequence have shown no significance difference between wild and cultured striped catfish. Vietnam species had shown a wide range of genetic distance of the intrapopulation compared with other countries in the range of 0.000-0.040 for CO1 gene and 0.003-0.008 for cytochrome b gene. The Neighbour-joining method has also been used to construct phylogenetic trees using CO1 gene; the tree formed few subclades with mixed populations, and the tree using cytochrome b showed only Vietnam species divided into a few sub-populations. For the other four countries, Thailand, Indonesia, India, and Philippines were in the same group. Hence, this study's findings may provide a reference for inter and intra-relationships of P. hypophthalmus that may help in the aquaculture activity of this striped catfish.
Improving the Photostabilization of Poly(vinyl chloride) Using 4-(benzylideneamino)benzenesulfonamide Tin Complex
Authors: Ghani Hassan , Yousif Emad , Kadhom Mohammed , Abdo Ahmed Waled , Yusop Muhammad Rahimi , Bufaroosha Muna 
Published: January 2022

The photostabilization of poly (vinyl chloride) (PVC) film filled with an organotin complex in its structure was examined and compared with the blank PVC film. The organotin (IV) complex that contains 4-(benzylideneamino) benzenesulfonamide as a ligand was synthesized and applied as a PVC photostabilizer. The impact of the complex on the polymer was assessed by comparing the properties of the films with and without the complex, before and after irradiation, using Fourier transform infrared spectroscopy, weight loss, viscosity change, atomic force microscopy, and field emission scanning electron microscopy (FE-SEM). Results showed that the complex film had lower weight loss, gel content, and molecular weight deterioration than the plain PVC film. Also, surfaces of the complexes-filled films were smoother, less lumpy, and more homogeneous. These findings were obtained via the FE-SEM and light microscope images and confirmed by measuring the roughness factor. The organotin (IV) complex proved its activity in delaying the photo-degradation of PVC by several mechanisms. Ultimately, the Tin complex has effectively protected the PVC film against irradiation.
The photostabilization of poly (vinyl chloride) (PVC) film filled with an organotin complex in its structure was examined and compared with the blank PVC film. The organotin (IV) complex that contains 4-(benzylideneamino) benzenesulfonamide as a ligand was synthesized and applied as a PVC photostabilizer. The impact of the complex on the polymer was assessed by comparing the properties of the films with and without the complex, before and after irradiation, using Fourier transform infrared spectroscopy, weight loss, viscosity change, atomic force microscopy, and field emission scanning electron microscopy (FE-SEM). Results showed that the complex film had lower weight loss, gel content, and molecular weight deterioration than the plain PVC film. Also, surfaces of the complexes-filled films were smoother, less lumpy, and more homogeneous. These findings were obtained via the FE-SEM and light microscope images and confirmed by measuring the roughness factor. The organotin (IV) complex proved its activity in delaying the photo-degradation of PVC by several mechanisms. Ultimately, the Tin complex has effectively protected the PVC film against irradiation.
Historia y memoria del pasado reciente: análisis del Diseño Curricular de Educación Física para el Nivel Preescolar durante la última dictadura cívico-militar argentina
Authors: Mansi Daniela 
Published: January 2022

El siguiente artículo porta como objetivo indagar sobre el Diseño Curricular de Educación Física para el Nivel Preescolar durante la última dictadura cívico - militar en Argentina. Dicho documento fue emitido en el año 1982 por la Secretaría de Educación de la Municipalidad de la Ciudad de Buenos Aires. Para ello, analizamos los componentes del documento curricular, particularizando la mirada en los objetivos del primer eslabón educativo y su fundamentación. A su vez, se realiza una relación con los objetivos generales del sistema educativo del período.
Como resultados preliminares, vemos que se manifiesta una pedagogía tecnicista y personalista de la Educación Física, desde las cuales se le atribuye la tarea de enseñar a hacer tareas motoras bajo un paradigma psicomotriz y desarrollista. Además, encontramos influencias de la Gimnasia Alemana. No obstante, se encuentran incoherencias entre la fundamentación de la Educación Física y los objetivos y actividades propuestas, los cuales se alejan de los conceptos de autonomía infantil y creatividad.
Cognitive and behavioral modernity in Homo erectus: skull globularity and hominin brain evolution
Authors: Clark Gary , Henneberg Maciej 
Published: January 2022

In this article we provide evidence that evolutionary pressures altered the cranial base and the mastoid region of the temporal bone more than the calvaria in the transition from H. erectus to H. sapiens. This process seems to have resulted in the evolution of more globular skull shape – but not as a result of expansion of the brain in the parietal regions but of reduction of the cranial base and the mastoid region relative to the parietals. Consequently, we argue that expansion of the parietals seems to be unrelated to brain evolution, but is more a by-product of reduction in other regions of the skull, reduction that may be related to dietary factors. Additionally, these findings suggest that cognitive and behavioural modernity may not necessarily be dependent on brain shape. Also, it cannot be attributed to the change in brain size because H. erectus and modern human cranial capacities overlap substantially. Consequently, we suggest H. erectus possessed the full suite of cognitive adaptations characteristic of modern humans without possessing a globular skull with flared parietals. Our results also support the theory that paedomorphic morphogenesis of the skull was important in the transition from H. erectus to H. sapiens and that such changes may be related to both dietary factors and social evolution.