bluuebunny/crossref_metadata_2025_split huggingface dataset:
N-doped TiO 2–carbon composites derived from NH 2 -MIL-125(Ti) for electrochemical determination of tert-butyl hydroquinone
Authors: Tang Jing , Li Jie , Liu Tianna , Tang Wenjing , Li Nali , Zheng Shengbiao , Guo Jiahao , Song Changchun 
Published: April 2022

Abstract
Electrochemical determination of tert-butyl hydroquinone (TBHQ) is vital to food safety due to negative health effects, however, bare electrode of traditional electrochemical sensors generally have narrow linear range and low sensitivity, limiting their practical application. Accordingly, a nano-architecture fabricated with N-doped TiO2–carbon nano-composites (TiO2/NC) based on the thermolysis of NH2 functionalized MIL-125 (Ti) Metal Organic Framework (NH2-MIL-125(Ti)) is firstly developed as an electrochemical material for electrochemical determination of TBHQ. The TiO2/NC composites with the highly porous structure, excellent conductivity and electron transportation, large surface area showed remarkable electrochemical oxidation ability for TBHQ. Under optimal conditions, TiO2/NC composites modified electrode presents a broader linear response to TBHQ concentration of 0.05–100 µM with the detection limit as low as 4 nM (S/N = 3). Finally, the sensor platform is implemented directly to determine TBHQ in edible oil for evaluation of its practical application. TiO2/NC composites sensor fabricated performs larger linear range with high sensitivity and anti-interference properties, providing a potential strategy for electrochemical determination of TBHQ.
Early introduction of the multi-disciplinary team through student Schwartz Rounds: a mixed methodology study
Authors: Abnett Harry , Tuckwell Robert , Evans Lucy 
Published: April 2022

Abstract
Background Medical education has changed continually throughout the covid-19 pandemic, creating additional stress for medical students. Personal reflection can empower an individual to adapt to new challenges, and reflection has gradually become incorporated into medical student training. Schwartz Rounds (SR) offer a compassionate group reflective forum for healthcare staff. SRs have been extensively introduced throughout the NHS, however medical student rounds are yet to be widely adopted. Entirely unresearched is how the multi-disciplinary team impacts a medical student SR.This study aims to compare medical student experience of a single-discipline and a multi-discipline SR. MethodsTwo virtual SRs were run at an NHS district general hospital, using the existing structure of the Trust’s rounds. The first round included only medical students on placement at the hospital, whereas the second round also involved other student health disciplines. Following each round Likert scale questionnaires were collected, and focus groups were held with a small number of participants. Quantitative analysis of the questionnaires was performed using averages and a paired T-test. Qualitative data from the focus groups underwent thematic analysis. ResultsThe quantitative data showed a positive response to both styles of student SRs, with over 87% of participants at both rounds stating they intended to attend further rounds. Direct comparison between the two rounds showed higher feedback scores for the single-discipline round, with a paired t-test p value of 0.007. Qualitative analysis showed strong student interest in further group reflection, noting the value of SRs in improving workplace culture and inter-professional relationships. The analysis also highlighted frustrations with the existing SR structure, namely large group sizes and scripted panellists. Conclusions Both data sets showed a strong positive response to SRs, and a desire to attend again. There is some evidence to suggest the addition of multiple student disciplines at SRs impaired medical student reflection. Changes to the format of the round could result in even greater success in student rounds.
Key informant perspectives on policy- and service-level challenges and opportunities for delivering adolescent and youth- friendly health services in public health facilities in a Nigerian setting
Authors: Arije Olujide , Hlungwani Tintswalo , Madan Jason 
Published: April 2022

Abstract
Background: Integrating the care of adolescents into existing public health facilities requires deliberate efforts. This study assessed key informant perspectives on policy and service-level challenges and opportunities for delivering adolescent and youth-friendly health services (AYFHS) in public health facilities in a Nigerian setting.Methods: Seventeen key informants were interviewed including members of the ASRH Technical Working Group (TWG), program managers of Non-Governmental Organizations (NGO), and State and local level health officials in Ogun State, Southwest Nigeria.Result: Findings from this study indicate that health workers continue to have a negative attitude towards adolescent and young people’s sexual and reproductive health. There was some level of inclusion of AYPs living with disabilities in ASTH programming which is welcome and extremely important. The coordination of activities of donors/partners working in the adolescent health space was said to be insufficient. Also, there was missed opportunity to strengthen policy implementation with research. Participants in this research expressed the need for increased focus on mental health, substance use, and other aspects of adolescent and young people’s health. Conclusion: This study provided the context of the implementation of a strategic framework for adolescent reproductive health in a Nigerian setting from the perspectives of policy and service-level stakeholders. The findings indicate the need for continued implementation of adolescent-responsive contraceptive services, expanding the reach of programs to include adolescents living with disabilities, stronger coordination among partners, and leveraging new sources of funding. Opportunities for improving program delivery identified include ensuring research-based policy implementation and seeking program sustainability through tapping into internal fundings such as the Basic Health Care Provisions Funds (BHCPF).
Minimally invasive surgery for Sanders type II–III calcaneal fractures with external fixator- assisted poking reduction and percutaneous screw fixation: a 2–5 years clinical and radiographic retrospective cohort study
Authors: Wang Jin-Chang , Lu Hai-Bo , Tang Jun-Jun , Zhang Jian , Wu Ke-Jian , Chen Hua , Shi Yong-Jing , Wang Guang-Lin 
Published: April 2022

Abstract
Background: For intra-articular calcaneal fractures of Sanders type II and above, open reduction and internal fixation could obtain anatomic reduction and firm fixation, however, there are high complications associated with surgery, such as incision infection and subtalar joint stiffness. As another treatment method, poking reduction and percutaneous fixation can reduce the complications. In this study, we introduce a new technique for external fixator-assisted reduction and computer-assisted preoperative design of the poking reduction and percutaneous screw fixation.Methods: Patients with calcaneal fractures who met the inclusion criteria were treated with external fixator-assisted poking reduction and percutaneous screw fixation at our hospital from March 2017 to September 2019, and the clinical and radiographic outcomes were evaluated.Results: A total of 31 patients were followed up, 10 cases of Sanders type II, and 21 cases of Sanders type III calcaneal fracture. The mean time from injury to operation was 3.2±1.9 days; the mean hospital stay was 7.3±3.1 days; the mean operation time was 87.74±30.30 min; and the mean intraoperative blood loss was 41.45±34.16 ml. Two patients underwent a change of surgical procedure and one underwent a second operation. Postoperative follow-up radiography showed good reduction of calcaneus length, height, width, Böhler angle, and Gissane angle. Postoperative follow-up CT showed good reduction of the subtalar articular surface in 83.6% of patients. At the last follow-up, the AOFAS score was 93.84±7.92, of which 24 cases were excellent, six cases were good, and one case was acceptable. The average range of motion of flexion and extension of the ankle joint on the injured side was 64.35±1.38°, which was not statistically different from that of the healthy side. The average range of motion of the subtalar joint was 29.27±1.63°, which was 88.6% of the healthy side, and two patients developed subtalar traumatic arthritis.Conclusion: External fixator-assisted poking reduction and percutaneous screw fixation is a safe and effective minimally invasive surgery for intra-articular calcaneal fractures, which has a lower incidence of postoperative complications and can reduce the impact on subtalar joint mobility, and increase the clinical effect. Trial registration: Retrospective cohort study.
Same-sex marriage legalization and employment outcomes among sexual minority adults in the U.S. Medical Expenditures Panel Survey
Authors: Samnaliev Mihail , Shanshan Liu , Agénor Madina , Austin S. Bryn 
Published: April 2022

Abstract
Background
Social science theories suggest that the legalization of same-sex marriage may lead to improved economic opportunities among sexual minorities. However, empirical evidence pertaining to this issue is scarce. We examined the association between state-level same-sex marriage legalization between 2004 and 2014 and employment outcomes among sexual minority men and women aged 18 years or older (N = 274) in 2015 using the U.S. Medical Expenditures Panel Survey.
Results
Legalization of same-sex marriage in the U.S. was associated with increased odds of employment among sexual minorities in regression models adjusting for individual-level sociodemographic factors, household–level characteristics, county-level economic and demographic factors, and state-level public attitudes towards sexual minorities. In addition, there was some evidence that the legalization of same-sex marriage may be associated with greater earnings and income among sexual minorities. There were no significant positive associations between same-sex legalization and any of the outcomes when the same analyses were repeated among heterosexual individuals (N = 10,330).
Conclusions
Our findings provide partial evidence that the legalization of same-sex marriage may have improved socioeconomic outcomes among U.S. sexual minorities.
Additional value of a triggerlist as selection criterion in identifying patients at high risk of medication-related hospital admission
Authors: Linkens Aimée , Janssen Myrthe , Nie Noémi van , Peeters Luc , Winkens Bjorn , Milosevic Vanja , Spaetgens Bart , Hurkens Kim , Kuy Hugo van der 
Published: April 2022

Abstract
Background 10-30% of the hospital admissions in older patients are medication-related. To increase the identification of medication-related hospital admissions in older patients a triggerlist is published in the Dutch guideline for Polypharmacy. Aim To assess whether the triggerlist has value (added to age and polypharmacy) as selection criterion to identify patients at high risk of medication-related hospital admissions. Method This sub-study was carried out in 100 older (≥ 60 years) patients with polypharmacy and having two triggers from the triggerlist. The admissions were assessed as either possibly or unlikely medication-related according to the Assessment Tool for identifying Hospital Admissions Related to Medications (AT-HARM10). Results 48% of the admissions were possibly medication-related. Conclusion The high prevalence of medication-related hospital admissions, suggests the triggerlist has added value as selection criterion in a cohort of older patients with polypharmacy and can be used to improve the identification of a population at high risk of medication-related hospital admissions.
Redox-dependent Structural Origin of the Temperature Threshold and Sensitivity in the TRPV3 Thermometer
Authors: Wang Guangyu 
Published: April 2022

Abstract
The DNA hairpin with a limited size is sensitive to temperature. However, it is unclear if thermosensitive TRP channels also use temperature-dependent hairpin sizes to govern their activation temperature thresholds and sensitivity. Here, graph theory, together with redox- and state-dependent cryo-electron microscopy structures of TRPV3 with or without an agonist at different temperatures, was to test this hypothesis. The results showed that the largest hairpin topological loop size and a change in the total hairpin sizes along the channel gating pathway control the temperature threshold and sensitivity, respectively. This size-dependent hairpin thermodynamics may mediate the thermal activity of biological macromolecules.
Neutrophils activated by cancer cells and M2 macrophages promote gastric cancer progression during PD-1 antibody-based immunotherapy
Authors: Zhou Chenfei , Yang Hui , Guo Liting , Cai Qu , Xi Wenqi , Liu Jing , Yuan Fei , Zhang Huan , Yan Chao , Zhu Zhenggang , Zhang Jun , Huang Lei , Shi Yan 
Published: April 2022

Abstract
Biomarkers of immune checkpoint inhibitors (ICIs) in advanced gastric cancer (AGC) are under investigation. In present study, correlation between neutrophil-to-lymphocyte ratio (NLR) and efficacy of ICIs treatment in AGC patients as well as its underlying mechanisms were investigated based on clinical cases and single-cell RNA sequencing (scRNA-seq) analysis. NLRs early after treatment were correlated with disease progression and poor progression-free survival (PFS) of AGC patients. Neutrophil cluster1 (NE-C1) divided by scRNA-seq was the major cluster in peripheral blood samples and its proportion increased after PD-1 antibody treatment. NE-C1 had a neutrophil activation phenotype with high expression of MMP9, S100A8, S100A9, PORK2, and TGF-β1. Subclusters of malignant epithelial cells (EP-C4) and M2 macrophages (MF-C1, MF-C2) showed high neutrophil activating phenotypes. Strong interactions among NE-C1, EP-C4, MF-C1 and MF-C2 were identified. In summary, posttreatment NLR can be an early prognostic biomarker of AGC patients treated by PD-1 antibody-based therapy. Neutrophils activated by both tumor cells and M2 macrophages participate in promoting gastric cancer progression during PD-1 antibody-based treatment.
Obolodiplosis robiniae Will Infect All Black Locust In Eurasia Under Climate Change
Authors: Zhao Jiaqiang , Gao Tai , Du Jingjing , Shi Juan 
Published: April 2022

Abstract
Obolodiplosis robiniae was discovered in Eurasia at the beginning of the 21st century and was then spread at an explosive rate. Here, we explore the current and future (in years 2050 and 2070) trends in the potential distribution of O. robiniae in Eurasia under diverse climate change scenarios based on a maximum entropy (MaxEnt) model. Our results showed that the current potential distribution area of O. robiniae is within the range of 21.58°-65.66°N in the Eurasian continent. The total current potential distribution (CPD) area of O. robiniae in Eurasia was 10,896,309.16 km2, with suitable areas covering a substantial section of Europe. The Annual Mean Temperature (Bio1), Annual Precipitation (Bio12), and the Precipitation of the Driest Month (Bio14) are the most important bioclimatic variables determining the potential distribution of O. robiniae. The future area suitable for habitat of O. robiniae is characterized by a large-scale northward expansion trend with temperature elevation. The marginally suitable and highly suitable areas would thus increase, whereas the southern appropriate areas would shrink. Under the SSP585 scenario, in 2070, the suitable area of O. robiniae would be the largest, up to 14,696,253.77 km2, which is 34.87% more than the current suitable area. This information would facilitate the provision of early warning on the potential distribution areas of O. robiniae issued by the forestry quarantine departments of Asian and European countries and provide a scientific basis for the prevention and control of O. robiniae spread and outbreaks.
Mechanical and corrosion characteristics of 6061-T6 Aluminum alloy samples reinforced with alumina micro and nanoparticles fabricated by Friction Stir Processing
Authors: Karami Ramin , Abdollahi Mir Ali Asghar 
Published: April 2022

Abstract
The present study investigates the mechanical and corrosion properties of reinforced 6061TT6 Aluminum samples after friction stir processing. Three different composites are fabricated: one without any powder and the others with micrometer and nanometer alumina powder (h) as reinforcing particles. The hardness, tensile, and Potentiodynamic polarization tests are performed to compare the new samples with the base metal. The results show that friction stir processing has increased the tensile and ultimate strength of the composites by an average of 181 % compared to the base metal. The strength of the composites with additives is significantly affected by the size of the particles. The hardness of the processed samples has also increased compared to the base metal by 200 %. Despite these enhancements, corrosion resistance of new samples has decreased, which can be due to the numerous dislocations in the stress-induced stir zone, creating lattice deformations and causing the breakdown of the passive protective layer. The analysis of fracture surface topography through a Fractography method revealed a specific anaglyph consisting of dimples of various shapes, sizes, and dispersion and further confirmed the tensile test results.
Media Contributions to a Chesapeake Bay Watershed Collective Identity:A Tale of Three Cities
Authors: Cui Zheng , Dillard James , Pinto Juliet , High Andrew , Cruz J.J. De La , Mainzer Stephen , Cole Charles 
Published: April 2022

Abstract
Although collective action is needed to address many environmental challenges, it cannot proceed in the absence of collective identity. The current study sought to address the question of whether or not a collective identity exists among residents of the Chesapeake Bay Watershed and, if so, what it might look like. The raw data were news stories drawn from local papers published in municipalities located at the headwaters of the Susquehanna River, midway down the Susquehanna, and where the river meets the bay. Computerized content analysis assessed the frequency with which the Chesapeake Bay and watershed were mentioned alongside a set of keywords thought to represent different facets of identity (e.g, agriculture, fishing, swimming). The results showed substantial variation in frequency across time and place, but, low absolute levels of coverage of the bay and the watershed. Multidimensional scaling revealed different structures to collective identity as a function of place. These differences in content may be attributable to varying demographic and environmental characteristics. Proximity to the bay may partially explain some of these differences, but, to the extent that a collective watershed identity exists at all, it is complex and heterogeneous.
The influence of information on residents' green housing purchasing behavior: different information contents and providers
Authors: He Chenchen , Liu Xuan , Li Jiaxin 
Published: April 2022

Abstract
Consumers' purchasing intention is the reaction to the external information stimulation. Therefore, information is one of the leading factors affecting consumers' behavior. To promote consumers to buy green housing, the paper tries to find the effect of information on consumers' green housing purchasing behavior. Instead of analyzing the overall influence of information, it discusses how different information contents improve consumers’ purchasing intention, especially for customers with different environmental protection attitudes. Moreover, it further analyzes the influences of different information providers, including developers, the government, and other green housing users. The results show that: 1) Consumers' age and environmental protection attitude have a significant impact on their purchasing behavior, while consumers' gender and monthly income have no significant impact; 2) Different information has different effects on residents' purchasing behavior. Specifically, consumers are more affected by information relating to the economy and indoor air quality. The detailed order of influence is as follows: information on loan at concessionary rates > cost saving in usage phase > indoor air quality > waste classification > investment benefit > carbon emission reduction > thermal comfort > acoustic environment > greening rate > luminous environment; 3) Consumers with higher environmental awareness care more about the information on living environment and carbon emission. Whereas, those with low awareness of environmental protection are more affected by information on economic benefits. 4) Regarding different information providers, the consumers are mostly impacted by government, while the information from developers could induce limited effects.
Cloning of Nine Glucocorticoid Receptor Isoforms from the Slender African lungfish (Protopterus dolloi)
Authors: Katsu Yoshinao , Oana Shin , Lin Xiaozhi , Hyodo Susumu , Bianchetti Laurent , Baker Michael E. 
Published: April 2022

Abstract
We wanted to clone the glucocorticoid receptor (GR) from slender African lungfish (Protopterus dolloi) for comparison to P. dolloi MR, which we had cloned and were characterizing, as well as for comparison to the GRs from humans, elephant shark and zebrafish. However, although sequencing of the genome of the Australian lungfish (Neoceratodus forsteri), as well as, that of the West African lungfish (Protopterus annectens) were reported in the first three months of 2021, we could not retrieve a GR sequence with a BLAST search of GenBank, when we submitted our research for publication in July 2021. Moreover, we were unsuccessful in cloning the GR from slender African lungfish using a cDNA from the ovary of P. dolloi and PCR primers that had successfully cloned a GR from elephant shark, sturgeon and gar GRs. On October 21, 2021 the nucleotide sequence of West African lungfish (P. annectens) GR was deposited in GenBank. We used this GR sequence to construct PCR primers that successfully cloned the GR from the slender spotted lungfish. Here, we report the sequences of nine P. dolloi GR isoforms and explain the basis for the previous failure to clone a GR from slender African lungfish using PCR primers that cloned the GR from elephant shark, sturgeon and gar. Studies are underway to determine corticosteroid activation of these slender African lungfish GRs.