bluuebunny/crossref_metadata_2025_split huggingface dataset:
Student Survey After Ten Years of Continuous Blended Teaching of Echocardiocraphy
Authors: Parra Víctor M. , Fita Guillermina , Azqueta Manel , González Mauricio , Aranda Fernando , Maestre MaLuz , Silva Jorge , Hortal Javier , Morales Daniel , Bórquez Emiliano , Adasme Fabián , Real María Isabel , Mercadal Jordi , Zelada Pamela , Riobó Gonzalo , Galdames Katia , Domenech Raúl J. 
Published: October 2022

Abstract

Aims: The aim of this study is to analyze the impact of 10 years of blended learning in echocardiography.
Methods and results: A total of 140 of 210 medical doctors who graduated from our teaching program from 2011 to 2020 responded to the survey. Among them, 53,57% were anesthesiologists and 26,42% intensivists. More than 85% of respondents indicated that the online period met their expectations, and 70,2% that the hands on practice met the objectives. Posterior to the Diploma there was a significant increase in the frequency of use of echo compared to before the Diploma, both in transthoracic and transesophageal echocardiography, from 24,29% to 40,71% and from 13,57% to 27,86%, respectively. The echo was applied mainly in the perioperative period (56,7%) and in intensive care (32,3%), and only in 11% of cases it was used in emergency units. Additionally, 92,4% of respondents revealed that it was very useful in their subsequent professional practice and 92,47% that it helped them in the interpretation of echo reports.
Among the strengths they highlighted ‘the theoretical content, clinical cases, hands on activity and the teaching staff’. Among the weaknesses, 50% requested a practice period lasting more than one week.
Conclusion: The blended learning of echocardiography over a decade has been satisfactorily evaluated by the graduated specialists and has been related to a significant increase in its use in the perioperative period and in intensive care. The main challenges are to establish a longer period of practice and achieve greater scope in Emergency Medicine.
Bianchi type cosmological models with heat flow in Lyra’s geometry
Authors: R Santhikumar , B Satyannarayana , Kornu Suryanaryana P S , E Satyannarayana P 
Published: October 2022

Abstract
Bianchi type-V cosmological model along with perfect fluid and heat conduction have been discussed in the presence of Lyra’s geometry(1951 Lyra et al.). By using the law of variation for the mean Hubble parameter the solution contains heat conduction and gauge function for \(n=0 and n\ne 0\), which is related to the average scale factor of metric and gives decelerating parameter. We discussed heat transmission stages from initial time to the late time of the universe. The relation between density and pressure is discussed. We obtain a constant decelerating parameter. Physical interpretation and thermodynamic laws are discussed.
Preparing state within target topological sector of lattice gauge theory model on quantum simulator
Authors: Qiu Xingze , Yan Zheng , Zhou Zheng , Wang Yan-Cheng , Meng Zi Yang , Zhang Xue-Feng 
Published: October 2022

Abstract
Simulating lattice gauge theory (LGT) Hamiltonian and its nontrivial states by programmable quantum devices has attracted numerous attention in recent years. Rydberg atom arrays constitute one of the most rapidly developing arenas for quantum simulation and quantum computing. The Z2 LGT and topological order has been realized in experiments while the U(1) LGT is being worked hard on the way. States of LGT have local constraint and are fragmented into several winding sectors with topological protection. It is therefore difficult to prepare a state in certain sector for experiments, and it is also an important task for quantum topological memory. Here, we propose a protocol of sweeping quantum annealing (SQA) for searching the state within target topological sector. With the Monte Carlo method, we show that this SQA has linear time complexity of size with applications to the antiferromagnetic transverse field Ising model, which has emergent U(1) gauge fields. This SQA protocol can be realized easily on quantum simulation platforms such as Rydberg atoms and superconducting circuits. We expect this approach would provide a generic recipe for resolving the topological hindrances in quantum optimization and the preparation of quantum topological state.
Detection method of rail surface defects based on deep learning
Authors: Xu Jianming 
Published: October 2022

Abstract
For the detection of uneven and irregular texture surface defects, the conventional image reconstruction is difficult because the background texture is a nonstationary signal. At the same time, because it is difficult to obtain the image feature information such as the shape and gray level of defects in advance, and the visual features of similar defects can show great dispersion, the existing detection methods that rely on target features are difficult to apply. According to the vibration theory and transient finite element-boundary element theory, a method of analyzing and detecting rail fracture defects by using rail vibration response data is proposed. By establishing the dynamic model of vibration analysis of ballastless track, the characteristics of vibration acceleration of track under the condition of complete rail fracture and 50% fracture of rail section under the periodic load excitation of nodes are studied. In this paper, an unsupervised learning surface defect detection method based on image inpainting is proposed.In this method, a small number of normal texture sample images should be used as training sets to train the network model. Then, during detection, the missing region is artificially set in the sample image, and the content of the missing region is predicted by using the network model. Finally, according to the structural similarity evaluation and residual error between the reconstructed image and the image to be tested, the defect detection and separation are realized. Experimental results show that the algorithm has strong generalization ability, can accurately segment defects of tile images with large amount of complex texture, uneven illumination and low contrast, and has strong robustness.
Heart Disease Prediction System Using Convolutional Neural Networks
Authors: VARKALA KRISHNAIAH 
Published: October 2022

Abstract
In computer visualization. Deep learning affords effective outcomes for machine learning complications. Several techniques like minimum distance technique, K-Nearest neighbor algorithm, Naïve Bayes, Support Vector Machine, and Artificial Neural Network are used for the purpose of medical data classification. In this paper, heart disease data classification is performed using convolutional neural network. Generally convolutional neural network uses and applied in image data sets, but, in proposed method is used to calculate the accuracy of event for heart disease data sets. The experiments are passed out using heart disease data set of Uel machine learning repository. This trained classifier can classify the given data into either normal or abnormal of heart disease data.
The simultaneous degradation of prochloraz and tebuconazole in water with identification of the main degradation products using liquid chromatography-tandem mass spectrometry.
Authors: Awwad Mahmoud M. , taha sherif M , Khalil Mostafa M.H. , Salem Abdelnaby Mohamed , Chovelonc Jean-Marc 
Published: October 2022

Abstract
Prochloraz and tebuconazole are well-known fungicides for broad-spectrum applications, including; medical, industrial, and agricultural. These fungicides are frequently used simultaneously for the protection of various agricultural products. The presence of these fungicides in water doesn't only affect the health of direct consumers but also limits their reuse. In this study, complete degradation of these fungicides and their degradation products were accomplished using thermal-activated persulfate. It takes only 30 min to degrade 97% and 98% of PCZ and TBZ, respectively, in their single presence in water using 1.4 mM persulfate and a temperature of 50 ºC. However, in their simultaneous presence in water, a treatment for a complete one hour is required to degrade 99% and 94% for PCZ and TBZ, respectively, at the same degradation conditions. The persulfate degradation of prochloraz was conducted by the cleavage of the imidazole ring and the subsequent formation of a trichlorophenol. While, persulfate degradation of tebuconazole was mainly accomplished by the formation of a hydroxyl structure, cleavage of the tert-butyl chain, and the subsequent formation of a di-ketone degradation product. The identification of PCZ and TBZ degradation products was determined using the liquid chromatography-tandem mass spectrometry technique (LC-MS/MS) at both positive and negative modes. The suggested structures of these degradation products and their dissipation were confirmed and monitored, respectively, using efficiently developed LC-MS/MS multiple reaction monitoring methods.
Agreement between a swept-source ocular coherence tomography biometrer, a spectral-domain ocular coherence tomography biometrer, and an optical low coherence reflectometry biometer in eyes with cataract
Authors: Zarei-Ghanavati Saimak , Nikpayam Majid , Namdari Maral , Bakhtiari Elham , Hassanzadeh Samira , Ziaei Mohammed 
Published: October 2022

Abstract
Background
This study aimed to assess the agreement between biometric parameters measured by a spectral-domain OCT optical biometer device (Optopol Revo NX) with a validated Swept-source biometer (IOLMaster 700) and a validated optical low coherence reflectometry (OLCR) biometer (Lenstar LS 900), in cataract surgery candidates.
Methods
In this prospective comparative study, 100 patients (100 eyes) who were eligible for cataract surgery were involved. Bland Altman analysis was used to assess agreement between devices for biometric parameters including axial length (AL), anterior chamber depth (ACD), lens thickness (LT), and central corneal thickness (CCT).
Results
AL measurements were successful in 82 eyes (82.0%) with Revo NX, in 91 eyes (91.0%) with Lenstar LS 900, and in 97 eyes (97.0%) with IOL Master 700. When Revo NX was compared to IOLMaster 700 and Lenstar LS 900, the mean differences were as follows: -0.02 ± 0.0.02 and − 0.02 ± 0.03 for AL, 0.01 ± 0.03 and 0.10 ± 0.03 (p < 0.05) for ACD, -0.15 ± 0.03 (p < 0.05) and 0.001 ± 0.04 for LT, and − 2.29 ± 0.92 (p < 0.05) and 0.73 ± 1.43 for CCT. There was a good correlation between devices for AL, ACD, LT, and CCT (ICC > 0.75). Bland-Altman analysis showed a narrower 95% limit of agreement (-0.35 to 0.31) between Revo NX and IOL Master 700 in measuring AL.
Conclusion
Despite the higher measurement failure rate in eyes with cataract, the Revo NX showed very good agreement with the IOL Master 700 and Lenstar LS 900 optical biometers in measuring AL, ACD, LT, and CCT. However, ACD and LT measurements can not be considered interchangeable between these devices.
BORN study: a multicenter randomized trial investigating cord blood RBC transfusions to reduce the ROP severity in extremely low gestational age neonates.
Authors: Teofili Luciana , Papacci Patrizia , Orlando Nicoletta , Bianchi Maria , Pasciuto Tina , Mozzetta Iolanda , Palluzzi Fernando , Giacò Luciano , Giannantonio Carmen , Remaschi Giulia , Santosuosso Michela , Beccastrini Enrico , Fabbri Marco , Valentini Caterina Giovanna , Bonfini Tiziana , Cloclite Eleonora , Accorsi Patrizia , Dragonetti Antonella , Cresi Francesco , Ansaldi Giulia , Raffaeli Genny , Villa Stefania , Pucci Giulia , Mondello Isabella , Santodirocco Michele , Ghirardello Stefano , Vento Giovanni 
Published: October 2022

Abstract
Background.
Extremely low gestational age neonates (ELGAN, i.e., neonates born before 28 weeks of gestation), are at high risk of developing retinopathy of prematurity (ROP), with potential long-life visual impairment. Due to concomitant anemia, ELGANs need repeated red blood cell (RBC) transfusions. These produce a progressive replacement of fetal hemoglobin (HbF) by adult hemoglobin (HbA). Furthermore, a close association exists between low levels of HbF and severe ROP, suggesting that a perturbation of the HbF-mediated oxygen release may derange retinal angiogenesis and promote ROP.
Methods/design.
BORN (umBilical blOod to tRansfuse preterm Neonates) is a multicenter double-blinded randomized controlled trial in ELGANs, to assess the effect of allogeneic cord blood RBC transfusions (CB-RBCs) on severe ROP development. Recruitment, consent and randomization take place at 10 Neonatology Intensive Care Units (NICUs) of 8 Italian tertiary Hospitals. ELGANs with gestational age at birth comprised between 24 + 0 and 27 + 6 weeks are randomly allocated into two groups: 1) standard RBC transfusions (adult-RBCs) (control arm); 2) CB-RBCs (intervention arm). In case of transfusion need, enrolled patients receive transfusions according to the allocation arm, unless an ABO/RhD CB-RBC is unavailable. Nine Italian public CB banks cooperate to make available a suitable amount of CB-RBC units for all participating NICUs. The primary outcome is the incidence of severe ROP (stage 3 or higher) at discharge or 40 weeks of post-menstrual age, which occurs first.
Discussion.
BORN is a ground-breaking trial, pioneering a new transfusion approach dedicated to ELGANs at high risk for severe ROP. In previous non-randomized trials, this transfusion approach was proven feasible and able to prevent the HbF decrease in patients requiring multiple transfusions. Should the BORN trial confirm the efficacy of CB-RBCs in reducing ROP severity, this transfusion strategy would became the preferential blood product to be used in severely preterm neonates.
Trial registration:
ClinicalTrials.gov Identifier: NCT05100212
A Dhdds K42E knock-in RP59 mouse model shows inner retina pathology and defective synaptic transmission
Authors: Nguyen Mai , Chakraborty Dibyendu , Rao Sriganesh Ramachandra , Onysk Agnieszka , Radkiewicz Mariusz , Surmacz Liliana , Swiezewska Ewa , Kraft Timothy , Sherry David , Fliesler Steven , Pittler Steven 
Published: October 2022

Abstract
Retinitis pigmentosa (RP) defines a group of hereditary progressive rod-cone degenerations that exhibit a common phenotype caused by mutations in over 70 genes. While most mutations in the dehydrodolichyl diphosphate synthase (DHDDS) gene result in syndromic abnormalities, some mutations cause non-syndromic RP (RP59). DHDDS encodes one subunit of the enzyme cis-prenyltransferase (CPT), which is required for the synthesis of dolichol (Dol), that is a necessary protein glycosylation cofactor. We previously reported the creation and initial characterization of a knock-in mouse model harboring the most prevalent RP59-associated DHDDS mutation (K42E) to understand how defects in DHDDS lead to retina-specific pathology. This model exhibited no profound retinal degeneration, nor protein N-glycosylation defects. Here, we report that the Dol isoprenylogue species in retina, liver, and brain of the K42E mouse model are shorter than in the corresponding tissues of age-matched controls, as reported in blood and urine of RP59 patients. Retinal transcriptome analysis demonstrated elevation of many genes encoding proteins involved in synaptogenesis and synaptic function. Quantitative retinal cell layer thickness measurements demonstrated a significant reduction in the inner nuclear layer (INL) and total retinal thickness (TRT) beginning at postnatal (PN) ∼2 months, progressively increasing to PN 18-mo. Histological analysis revealed cell loss in the INL, outer plexiform layer (OPL) disruption, and ectopic localization of outer nuclear layer (ONL) nuclei into the OPL of K42E mutant retinas, relative to controls. Electroretinograms (ERGs) of mutant mice exhibited reduced b-wave amplitudes beginning at PN 1-mo, progressively declining through PN 18-mo, without appreciable a-wave attenuation, relative to controls. Our results suggest that the underlying cause of DHDDS K42E mutation driven RP59 retinal pathology is defective synaptic transmission from outer to inner retina.
One step double augmentation with human dermis allograft and homologous PRP in misdiagnosed/chronic Achilles tendon ruptures.
Authors: Lughi Marcello , Moretti Cinzia , Ferretti Matteo , Bondioli Elena , Maitan Nicolò , Casadei Roberto 
Published: October 2022

Abstract
Background. Misdiagnosed/chronic Achilles tendon injuries are rare and disabling for patients. Surgical treatment of this type of injury guarantees optimal clinical and functional results by exploiting the proven regenerative potential of allografts of decellularized dermis and growth factors released from platelets concentrated in plasma. In this study, we mainly describe the surgical technique, original and not found in the literature, of using a biological graft (allograft of decellularized dermis) and homologous thrombin-activated PRP in a single step. Secondly, we evaluated results obtained at a minimum follow-up of 18 months and a maximum of 24 months. Methods. All patients of this study complained of pain, but above all of severe functional limitation that Achilles tendon injury had been causing for more than a month. Surgical approach, always used by the first author, respected predefined steps: careful dissection and preparation of the peritendinous tissues from suture to the end of the procedure, tenorrhaphy and augmentation with allopatch to obtain a mechanically effective repair to avoid recurrences, and finally 'biological' augmentation with a unit of homologous thrombin-activated PRP. We offered to all patients a regenerative rehabilitation program post-operatively. Results. All patients were evaluated clinically (functional clinical tests and questionnaires) and instrumentally (elastosonography and perfusion MRI). In all patients pain was resolved and district function and kinetic chains improved with resumption of daily activities, work and sports. Conclusions. The optimal results found confirm the regenerative potential of decellularized dermis allograft and PRP (homologous and thrombin-activated) in our study. This potential can also be exploited in cases of severe tendon destructuring and limited 'intrinsic' regenerative potential and at any age. The proposed one-step surgical technique of a double augmentation therefore appears useful, safe, reproducible and applicable in all chronic tendon lesions with low regenerative potential.
Epidemiological and therapeutic analyses of lung cancer patients in the Hokushin region: a retrospective hospital administrative database study
Authors: Kobayashi Takashi , Nishino Yoshikazu , Takiguchi Tomoya , Kanda Shintaro , Otsuki Kengo , Tanaka Yuriko , Nakazawa Yozo , Ito Ken-ichi , Hayashi Ryuji , Yasumoto Kazuo , Uramoto Hidetaka , Hirono Yasuo , Makino Tomoe , Nakada Mitsutoshi , Yano Seiji , Koizumi Tomonobu 
Published: October 2022

Abstract
Objective
This study was performed to validate the epidemiology, initial treatment, and clinical practice in lung cancer patients in the Hokushin region, Japan.
Methods
We surveyed retrospective data of newly diagnosed and registered lung cancer patients in 22 principal hospitals in Hokushin region linked with health insurance claims data for registered patients between 2016 and 2017.
Results
A total of 5503 lung cancer cases were newly diagnosed in Hokushin region during the study period. These patients consisted of 3677 (66.8%) men and 1826 (33.2%) women, with a median age of 72.2 years (range, 27 – 103 years). Diagnoses were small cell lung cancer in 512 (9.4%) cases, squamous cell carcinoma in 1083 (19.7%), and non-squamous non-small cell lung cancer in 3906 (70.9%). The population with stage I disease in Toyama prefecture (41.1%) was lower than in the other three prefectures associated with reduced selection of initial surgery therapy and increased frequencies of stage IV disease (33.2%) and best supportive care (18.6%). Initial chemotherapy for stage IV non-squamous NSCLC consisted of tyrosine kinase inhibitors in 39.3% of cases for EGFR and 4% of cases for ALK-positive non-squamous NSCLC, followed by platinum compounds (25.9%) non-platinum compounds (12.9%), and immune checkpoint inhibitors (10.2%). Carboplatin was the commonly prescribed first-line cytotoxic chemotherapeutic agent in 65.4% of patients under 75 years old and in 96.7% of patients over 75 years old.
Conclusion
This study revealed real-world data on epidemiological and treatment status in lung cancer in four prefectures in Hokushin region, Japan.
Carcinogenic and Non-carcinogenic Risk Assessment Induced by Pesticide Residues in Fresh Pistachio in Iran Based on Monte Carlo Simulation
Authors: Mahdavi Vahideh , Omar Sharaf S. , Zeinali Tayebeh , Sadighara Parisa , Fakhri Yadolah 
Published: October 2022

Abstract
This research is aimed at analysis 88 pesticides in 30 fresh pistachio samples prepared from stores in Iran by QuEChERS-Ultra-High Performance Liquid Chromatography-tandem mass spectrometry (UHPLC-MS/MS). The results showed at least one pesticide was in 67% of fresh pistachio samples. Kresoxim methyl residue was detected in 20 samples with average of 0.11 mg kg− 1, this average is 2.2 times more than MRL. buprofezin in 5 samples with average of 0.17 mg kg− 1 was observed with 3.4 times more than MRL, hexaconazole and permethrin were recognized in 3 samples lower than MRL with average residue of 0.030 and 0.028 mg kg− 1, respectively. In addition, potential non-carcinogenic and carcinogenic health risk assessments were evaluated using probabilistic methods performed with the Monte Carlo simulation algorithm. The order of pesticide ranking based on HQ was hexaconazole > buprofezin > permethrin > kresoxim methyl. Total HQ (HI) was 2.0E-4 and for children 9.0E-4 hence it means fresh pistachio consuming maybe not have significant short-term health risks for cosumers. Ranking based on CR was hexaconazole > kresoxim methyl > metalaxyl > permethrin > buprofezin. However, total CR due to pesticide residues was not higher than 1E-6 value (1.09E-9) therefore, consumers were not at significant risk of carcinogenicity in this product.
Social determinants of health and well-being among irregular migrant workers in Malaysia: A case study of Chin people from Myanmar
Authors: Khai Tual Sawn 
Published: October 2022

Abstract
Background
Malaysia is the second-most popular destination for regular and irregular migrant workers from Myanmar. They contribute to the economic prosperity of both the host and home countries; yet, their social determinants of health and physical well-being, particularly among irregular migrants remain neglected and unexplored. This study looked at how Myanmar irregular migrant workers' daily challenges, workplace exploitation and conditions, and coping strategies related to the social determinants of their health and well-being.
Methods
Two interview techniques were used in this study: semi-structured interviews with nine participants (n = 9), and three Focus Group Discussions with sixteen participants (n = 16). Participants were recruited through referrals from NGOs and snowball sampling due to the nature of the hidden population.
Results
The findings revealed that a variety of factors are affecting participants' health and well-being. Among the most pressing issues is their irregular immigrant status, which exposes them to various forms of exploitation and prevents them from accessing services. They suffer from depression, overthinking, worries about their families, and insomnia as a result of such conditions. Some relied on religious devotion (prayer), ignoring their sadness and dedication to support their families, while others relied on cohabitation or drinking alcohol, damaging their physical and mental health.
Conclusions
The findings suggest that Myanmar and Malaysian governments should collaborate to regularize existing irregular migrants in Malaysia and establish zero or low-cost recruitment policies to eliminate irregular migration for prospective workers since their labour contributions play a significant role in both countries' economies.