bluuebunny/crossref_metadata_2025_split huggingface dataset:
Galbanic Acid Improves Accumulation and Toxicity of Arsenic Trioxide in MT-2
Cells
Authors: Rassouli Fatemeh B. , Rafatpanah Houshang , Mahdifar Maryam , Iranshahi Mehrdad , Goudarzi Sajad , Golizadeh Marzieh 
Published: July 2022

Background:
Galbanic acid (GBA) is a sesquiterpene coumarin with valuable pharmacological effects.
Adult T-cell lymphoma (ATL) is an aggressive lymphoid malignancy with a low survival rate. Although arsenic trioxide
(ATO) is a standard therapeutic agent for ATL treatment, the efficacy of chemotherapy is limited due to the chemoresistance
of cells.

Objective:
The present study was carried out to investigate whether GBA in combination with ATO would improve
cytotoxicity against ATL cells.

Methods:
GBA was isolated from the roots of Ferula szowitsiana by column chromatography on silica gel. MT-2 cells
were treated with 20 μM GBA + 4 μM ATO, and viability was evaluated by alamarBlue assay. The cell cycle was
analyzed by PI staining, while the activity of P-glycoprotein (P-gp) was evaluated by mitoxantrone efflux assay. To
understand the molecular mechanisms of GBA effects, the expression of NF-κB (RelA), P53, CDK4, c-MYC, c-FLIPL,
and c-FLIPS was evaluated using real-time PCR.

Results:
Combinatorial use of GBA + ATO significantly reduced the viability of MT-2 cells and induced cell cycle
arrest in the sub-G1 phase. GBA improved mitoxantrone accumulation in cells, indicating that this agent has inhibitory
effects on the functionality of the P-gp efflux pump. Moreover, real-time PCR analysis revealed that GBA + ATO
negatively regulated the expression of P53, CDK4, c-FLIPL, and c-FLIPS.

Conclusion:
Due to the interesting effects of GBA on the accumulation and toxicity of ATO, combinatorial use of
these agents could be considered a new therapeutic approach for ATL treatment.
Comparative Study of Phasor and Frequency Estimation Algorithms for
Distribution Networks
Authors: Shahed Md. Tanvir 
Published: July 2022

Abstract:
Next-generation phasor measurement units (PMUs) are critical for proper distribution
network monitoring in future smart grids. In the highly dynamic environments of future distribution
systems, more advanced algorithms for detecting amplitude, phase, and frequency changes in
power waveforms will be required. In this context, the goal of this study is to discuss the advantages
and disadvantages of commonly used PMU algorithms. Many commonly used approaches
for power system phasors and frequency estimation algorithms for distribution networks are reviewed
and evaluated in this work from the perspective of phasor and frequency identification. According
to various performance criteria, e-IpDFT (Enhanced Interpolated Discrete Fourier Transform)
and DDPE (Dictionary-based Dynamic Phasor Estimator) provided the best performance
among the algorithms. This study provides some insights into the shortcomings of current phasor
estimation algorithms and will be useful in the development of future estimation techniques.
Perceptions and Discussions of Snus on Twitter: Observational Study
Authors: Chen Jiarui , Xue Siyu , Xie Zidian , Li Dongmei 
Published: July 2022

BackgroundWith the increasing popularity of snus, it is essential to understand the public perception of this oral tobacco product. Twitter—a popular social media platform that is being used to share personal experiences and opinions—provides an ideal data source for studying the public perception of snus.ObjectiveThis study aims to examine public perceptions and discussions of snus on Twitter.MethodsTwitter posts (tweets) about snus were collected through the Twitter streaming application programming interface from March 11, 2021, to February 26, 2022. A temporal analysis was conducted to examine the change in number of snus-related tweets over time. A sentiment analysis was conducted to examine the sentiments of snus-related tweets. Topic modeling was applied to tweets to determine popular topics. Finally, a keyword search and hand-coding were used to understand the health symptoms mentioned in snus-related tweets.ResultsThe sentiment analysis showed that the proportion of snus-related tweets with a positive sentiment was significantly higher than the proportion of negative sentiment tweets (4341/11,631, 37.32% vs 3094/11,631, 26.60%; P<.001). The topic modeling analysis revealed that positive tweets focused on snus’s harm reduction and snus use being an alternative to smoking, while negative tweets focused on health concerns related to snus. Mouth and respiratory symptoms were the most mentioned health symptoms in snus-related tweets.ConclusionsThis study examined the public perception of snus and popular snus-related topics discussed on Twitter, thus providing a guide for policy makers with regard to the future formulation and adjustment of tobacco regulation policies.
Substitution of Corn Flour and Additional Palm Sugar to Cookies Characteristics
Authors: Dewi Ni Kadek Karina Sari , I Wayan Sudiarta  , I Nyoman Rudianta  
Published: July 2022

Cookies are biscuits made from low protein flour, and have a crunchy texture. Corn flour substitute was chosen because corn flour only contains <1% gluten. The main problem faced by corn commodity lies in the low sugar content as energy. To produce cookies that have nutritional value, palm sugar is added, where the constituent sugar is simpler than granulated sugar. This study aims to determine how the effect of corn flour substitution and the addition of palm sugar on the physicochemical and organoleptic characteristics of cookies. The design used was a Completely Randomized Design (CDR) with two factors and two replications, the first factor was corn flour substitution which consisted of four levels, namely 0%, 15%, 30%, 45%. The second factor is the addition of palm sugar which consists of three levels, namely 15%, 20%, 25%. Observations were made objectively including water content, ash content, protein content, fat content, carbohydrate content, crude fiber content and color. While subjectively include, color, aroma, texture, taste and overall acceptance. The results obtained the best formulation of cookies substituted with 30% corn flour and 20% palm sugar with a water content of 6.39%, ash content of 2.45%, protein content of 10.19%, fat content of 29.90%, carbohydrate content 51.08%, and 0.09% crude fiber content.

Cookies are biscuits made from low protein flour, and have a crunchy texture. Corn flour substitute was chosen because corn flour only contains <1% gluten. The main problem faced by corn commodity lies in the low sugar content as energy. To produce cookies that have nutritional value, palm sugar is added, where the constituent sugar is simpler than granulated sugar. This study aims to determine how the effect of corn flour substitution and the addition of palm sugar on the physicochemical and organoleptic characteristics of cookies. The design used was a Completely Randomized Design (CDR) with two factors and two replications, the first factor was corn flour substitution which consisted of four levels, namely 0%, 15%, 30%, 45%. The second factor is the addition of palm sugar which consists of three levels, namely 15%, 20%, 25%. Observations were made objectively including water content, ash content, protein content, fat content, carbohydrate content, crude fiber content and color. While subjectively include, color, aroma, texture, taste and overall acceptance. The results obtained the best formulation of cookies substituted with 30% corn flour and 20% palm sugar with a water content of 6.39%, ash content of 2.45%, protein content of 10.19%, fat content of 29.90%, carbohydrate content 51.08%, and 0.09% crude fiber content.
Consistent Effects of Hypoglycemia on Cognitive Function in People With or Without Diabetes
Authors: Verhulst Clementine E.M. , Fabricius Therese W. , Nefs Giesje , Kessels Roy P.C. , Pouwer Frans , Teerenstra Steven , Tack Cees J. , Broadley Melanie M. , Kristensen Peter L. , McCrimmon Rory J. , Heller Simon , Evans Mark L. , Pedersen-Bjergaard Ulrik , de Galan Bastiaan E. 
Published: July 2022

OBJECTIVE
Hypoglycemia poses an immediate threat for cognitive function. Due to its association with acute cognitive impairment, the International Hypoglycemia Study Group (IHSG) defines a blood glucose level &lt;3.0 mmol/L as “level 2 hypoglycemia.” In the current study we investigated whether having diabetes, type of diabetes, or hypoglycemia awareness moderates this association.

RESEARCH DESIGN AND METHODS
Adults with type 1 diabetes with normal (n = 26) or impaired (n = 21) hypoglycemic awareness or with insulin-treated type 2 diabetes (n = 15) and age-matched control subjects without diabetes (n = 32) underwent a hyperinsulinemic-euglycemic-hypoglycemic glucose clamp (2.80 ± 0.13 mmol/L [50.2 ± 2.3 mg/dL]). At baseline and during hypoglycemia, calculation ability, attention, working memory and cognitive flexibility were measured with the Paced Auditory Serial Addition Test (PASAT) and the Test of Attentional Performance (TAP).

RESULTS
For the whole group, hypoglycemia decreased the mean ± SD proportion of correct answers on the PASAT by 8.4 ± 12.8%, increased reaction time on the TAP Alertness task by 32.1 ± 66.6 ms, and increased the sum of errors and omissions on the TAP Working Memory task by 2.0 ± 5.5 (all P &lt; 0.001). Hypoglycemia-induced cognitive declines were largely irrespective of the presence or type of diabetes, level of symptomatic awareness, diabetes duration, or HbA1c.

CONCLUSIONS
IHSG level 2 hypoglycemia impairs cognitive function in people with and without diabetes, irrespective of type of diabetes or hypoglycemia awareness status. These findings support the cutoff value of hypoglycemia &lt;3.0 mmol/L (&lt;54 mg/dL) as being clinically relevant for most people with diabetes.
PRODUKTIVITAS JAMUR TIRAM PUTIH (Pleurotus ostreatus) PADA MEDIA LIMBAH SEKAM PADI DAN DAUN PISANG KERING SEBAGAI MEDIA ALTERNATIF
Authors: Suparti Suparti , Marfuah Lismiyati 
Published: July 2022

Jamur tiram putih (Pleurotus ostreatus) merupakan jenis jamur pangan yang banyak dikonsumsi mengandung protein 27%. Kandungan protein pada jamur tiram putih dapat dipengaruhi oleh komposisi media tanam seperti selulosa, hemiselulosa, lignin dan nutrisi tambahan. Sekam padi dan daun pisang kering merupakan salah satu limbah organik yang dapat digunakan sebagai media alternatif untuk meningkatkan produktivitas jamur tiram putih.Tujuan penelitian ini adalah untuk mengetahui produktivitas jamur tiram putih yang ditumbuhkan pada media limbah sekam padi dan daun pisang kering sebagai media alternatif. Jenis penelitian eksperimen dengan metode rancangan acak lengkap (RAL) dua faktor yaitu faktor 1 penambahan sekam padi dan faktor 2 daun pisang kering (0%, 5%, 10%, 15%), masing-masing dengan empat perlakuan dan dua kali ulangan. Hasil analisis data menunjukkan bahwa penambahan sekam padi dan daun pisang kering 15% (S3T3) memberikan pengaruh nyata terhadap lama penyebaran miselium, jumlah badan buah dan berat segar jamur tiram putih.Perlakuan yang paling baik untuk pertumbuhan jamur pada perlakuan S3T3, dengan rata-rata lama penyebaran miselium 25,5 hari, jumlah badan buah 64,5 buah dan berat segar yang dihasilkan 402,5. Hasil data tersebut lebih tinggi dibandingkan dengan perlakuan yang lain.
Keanekaragaman Mollusca (Bivalvia Dan Polyplacophora) Di Wilayah Pesisir Biluhu Provinsi Gorontalo
Authors: Baderan Dewi Wahyuni , Hamidun Marini Susanti , Utina Ramli 
Published: July 2022

Bivalvia dan Polyplacophora menjadi salah satu dari beragam sumber daya hayati yang dimanfaatkan oleh sebagian besar masyarakat Indonesia baik secara lokal maupun dalam skala besar sejak dulu. Meskipun demikian, data dasar terkait pola distribusi maupun keanekaragaman Bivalvia dan Polyplacophora masih sangat terbatas, bahkan jika dibuat perbandingan dengan Kelas Gastropoda yang kerabat dekatnya.. Tujuan penelitian ini: 1) untuk mengetahui komposisi jenis Bivalvia dan Polyplacophora; 2) mengetahui nilai Indeks Keanekaragaman, Kemerataan dan kekayaan Jenis; dan 3) nilai kepadatan. Metode yang digunakan adalah metode jelajah. Penelitian ini menemukan enam spesies Bivalvia dan Polyplacophora yakni Hippopus hippopus, Mactra cuneata, Anadara antiquata, Tucetona pectunculus, Pinctada margaritifera dan Achantopleura gemmata. Tingkat keanekaragaman tertinggi berada pada stasiun I dengan nilai H'=1,641. Indeks kemerataan (E) Bivalvia dan Polyplacophora secara berurut pada stasiun I, II, dan III yakni 0,916; 0,821; 0,9. Indeks kekayaan jenis Bivalvia dan Polyplacophora dimana stasiun I berjumlah 1,3294, stasiun II berjumlah 1,6981 dan stasiun III berjumlah 1,5533. Nilai kepadatan tertinggi dimiliki oleh spesies Hippopus hippopus pada stasiun I yakni 0,0008 Ind/m2. Spesies dengan nilai kepadatan terendah yakni tiga spesies (Anadara antquata, Tucetona penctuculus dan Achantopleura gemmate) pada stasiun II, dan spesies Tucetona penctuculus pada stasiun III dengan nilai kepadatan masing-masing sebesar 0,00004 Ind/m2.
The Innovation and the Transformation of Indonesian Schools Accreditation Management System
Authors: Susetyo Budi , Soetantyo Sylvia P. , Sayuti Muhammad , Nur Darfiana 
Published: July 2022

All schools at the primary and secondary education levels in Indonesia must be accredited. An independent body called the National Accreditation Board for Schools/Madrasah (BAN-S/M) as an external quality assurance agency, accredits schools throughout Indonesia. Since 2005, the percentage of schools accredited in levels A and B has always increased from year to year based on the accreditation results. However, the improvement of school quality based on accreditation did not strongly correlate with the national exam and PISA results. This article discusses the facts of the experience of implementing accreditation for 15 years which became the basis for accreditation reform in Indonesia. BAN-S/M started the reformation in 2020 with three fundamental changes. First, the change in the accreditation instrument from compliance-based to performance-based. Second, the recruitment of new assessors based on cognitive competence and personality. Third, the changes of the accreditation business process through the dashboard monitoring system that will select schools with automatic accreditation extensions without visitation and schools that assessors must visit. implementation of Innovation and accreditation management reform can reduce accreditation costs by more than 60% and is expected to increase the accuracy of school quality assessment results. The findings strengthen the current transformation to the new, more efficient, rational accreditiation management system for schools/madrasah.
PENINGKATAN KREATIVITAS DAN PRESTASI BELAJAR MATEMATIKA KONSEP POLA BILANGAN MELALUI PEMBERIAN TUGAS MANDIRI PADA SISWA
Authors: Sulistyo Daryono Mardi 
Published: July 2022

Penulisan ini bertujuan untuk mengetahui peningkatan kreativitas dan prestasi belajar siswa menggunakan pemberian tugas mandiri dalam pembelajaran Matematika pada siswa. Penelitian tindakan kelas ini dilaksanakan dalam 2 siklus. Hasil penelitian menunjukkan bahwa kreativitas siswa dalam pembelajaran Matematika pada siklus I rata-rata 37,58 dan siklus II rata-rata 39,60 terdapat kenaikan 2,02 angka atau sekitar 5,37%. Prestasi belajar dalam pembelajaran Matematika pada siklus I rata-rata 63,25 dan siklus II rata-rata 70,45 terdapat kenaikan 9,92 angka atau sekitar 16,08%. Akumulasi kalsifikasi penilaian hasil ulangan Matematika dalam pembelajaran Matematika pada siklus II juga mengalami kenaikan, yaitu pada siklus II klasifikasi nilai rendah 0%, nilai cukup hanya 37,5% dan nilai tinggi 62,5%. Dengan demikian, dapat disimpulkan bahwa pada siklus II telah terjadi kenaikan, hal ini menunjukkan pada siklus II telah berhasil dengan optimal. Penulis saat menyampaikan secara tertulis mengenai pemberian tugas kepada siswa, dan siswa secara keseluruhan mengisi atau menjawab sangat setuju dan memberikan alasan bahwa pemberian tugas sangat penting untuk melatih dan membiasakan kemandirian, rasa tanggung jawab, dan kreativitas siswa. Hal ini membuktikan bahwa pemberian tugas diperlukan dalam pembelajaran Matematika dan meningkatkan hasil belajar siswa. Pemberian tugas, terutama diimplementasikan di sekolah dalam pengawasan guru secara langsung
Peningkatan Aktivitas Belajar dan Keterampilan Menyusun Teks Cerita Inspiratif dalam Pembelajaran Bahasa Indonesia Melalui Discovery Learning pada Siswa Kelas IXB Semester 2 SMP Negeri 1 Teras
Authors: Hartati Sri 
Published: July 2022

Tujuan penelitian, mendeskripsikan peningkatan aktivitas dan keterampilan menyusun teks cerita inspiratif dalam pembelajaran bahasa Indonesia pada siswa kelas IXB di SMP Negeri 1 Teras Boyolali tahun 2019/2020. Subjek penelitian, siswa kelas IXB sebanyak 30 siswa. Metode pengumpulan data dengan observasi, catatan lapangan, wawancara, dan analisis dokumen dalam penelitian tindakan kelas dua siklus. Hasil penelitian, aktivitas siswa pada prasiklus rata-rata masih rendah, siswa pasif, tidak berani bertanya atau menjawab pertanyaan. Pada siklus 1 mengalami peningkatan. Siswa lebih aktif, lebih percaya diri. Siklus II rata-rata lebih aktif, berani bertanya atau menjawab pertanyaan, lebih percaya diri. Berarti terjadi peningkatan akumulasi klasifikasi aktivitas belajar siswa dalam pembelajaran bahasa Indonesia pada siklus II. Akumulasi klasifikasi penilaian keterampilan menyusun teks cerita inspiratif pada prasiklus, siklus I, dan siklus II mengalami kenaikan yang berarti. Pada prasiklus, nilai tertinggi 80, nilai terendah 40, dan nilai rata-rata kelas 60. Prestasi belajar pada siklus 1, nilai terendah 46, nilai tertinggi 86, dan nilai rata-rata 65,60. Hasil belajar siklus I masih berada dibawah KBM yaitu 68. Hasil belajar pada siklus II, nilai terendah 66, nilai rata-rata 79,13, dan nilai tertinggi 93. Pada siklus II terjadi kenaikan yang signifikan. Berarti pada siklus 2 telah berhasil dengan optimal.
Meta Analisis: Problem Based Learning (PBL) Terhadap Kemampuan Pemahaman Konsep Peserta Didik
Authors: Muh. Fairus Ismail  , Yuliany Nur , Savitri Dewi 
Published: July 2022

Tujuan dari penelitian ini untuk mengetahui: 1) pengaruh Problem Based Learning terhadap pemahaman konsep peserta didik secara keseluruhan; 2) pengaruh Problem Based Learning terhadap pemahaman konsep peserta didik ditinjau dari jenjang pendidikan; 3) pengaruh Problem Based Learning terhadap pemahaman konsep peserta didik ditinnjau dari tahun publikasi. Metode yang digunakan dalam penelitian ini adalah metode kuantitatif dengan desain penelitian meta analisis serta jenis penelitian yang digunakan adalah jenis Group Contrasts. Pengumpulan data dilakukan peneliti dengan mencari artikel publikasi yang relevan atau berkaitan dengan topik yang akan diteliti dalam situs jaringan internet berupa Google Scholar, Repositori, dan Open Knowledge Maps. Teknik pengambilan sampel menggunakan teknik purposive sampling. Instrumen yang digunakan adalah lembar kode data yang merangkum data dan informasi data. Data dianalisis dengan menghitung nilai effect size menggunakan rumus standardized means difference. Berdasarkan analisis yang dilakukan diperoleh: 1) Metode Problem Based Learning secara keseluruhan efektif (signifikan) dalam meningkatkan kemampuan pemahaman konsep peserta didik, ditemukan 15 artikel publikasi dengan mean effect size sebesar 0,773, dan tergolong kategori besar; 2) Metode Problem Based Learning berdasarkan jenjang pendidkan efektif (signifikan) dalam meningkatkan kemampuan pemahaman konsep peserta didik. Pada jenjang SMP ditemukan 9 artikel publikasi dengan rata-rata efek sebesar 0,785 dan tergolong kedalam kategori besar, sedangkan pada jenjang SMA ditemukan 6 artikel publikasi dengan rata-rata efek sebesar 0,754 dan tergolong kedalam kategori besar; 3) Metode Problem Based Learning berdasarkan tahun publikasi efektif (signifikan) dalam meningkatkan kemampuan pemahaman konsep peserta didik.
Research on Stability of Time-delay Force Feedback Teleoperation System Based on Scattering Matrix
Authors: Wang Chunxu , Shi Feipeng , Li Lipeng , Alhamami Mohammed 
Published: July 2022

Abstract
The successful implementation of the robot teleoperation system has greatly improved the ability of remote robots. The force feedback technology is applied to the teleoperation system. On the one hand, the main operator manipulates the operator’s related movement information to the target robot; on the other hand, the main hand feeds back the force situation of the target robot in the remote control to the operator. From the robot under the control of the system can more accurately complete the task, with a higher work efficiency. Teleoperation system with force feedback function generally adopts bilateral control, the master and slave end of the system have a certain delay in the transmission process, it makes the stability of the system destroyed. This paper uses a two-port network to simulate the communications link of the teleoperation system as a lossless transmission line, solves the stability problem of teleoperation systems with force feedback in the presence of time delay effectively. Experimental simulation results show that this method can guarantee a higher stability of the system..
Extraction of B12 Reference Intervals from a Large Amount of General Patient Data
Authors: Gavars Didzis , Perminov Dmitry , Tauckels Eriks , Lindenberga Ilze , Tutāne Anna , Auce Agris 
Published: July 2022

Abstract
This study compared the reference intervals (RI) of B12 vitamin concentration in blood found in the literature with RIs extracted from data accumulated from a large number of patients by E. Gulbis Laboratory in Latvia. This paper investigated and demonstrated the possibility of using large amounts of random patient data to establish the RI for clinical laboratory tests. The blood level of B12 vitamin was selected as the model system for this study. The study used blind data for B12 blood level measurements from 132 379 patients accumulated in E. Gulbis Laboratory over a period of 15 years. In order to establish the reference intervals, the frequency distribution of log transformed B12 values was fit to a Gaussian distribution. The established B12 reference interval of 196 pg/ml and 942 pg/ml was found to be in good agreement with RIs reported elsewhere.
Proximidade pessoal, dissidência disruptiva e governança urbana participativa como formas de ativismo pela mudança climática por meio da agricultura urbana
Authors: Simon Sandrine 
Published: July 2022

A luta contra as mudanças climáticas é uma longa batalha que está longe de ser vencida. Negociações e acordos formais sobre mudanças climáticas vêm sendo conduzidos há décadas e metas foram estabelecidas para impor reduções nas emissões de gases de efeito estufa a governos e grandes indústrias. Além disso, os cidadãos começaram a explorar maneiras de participar. Depois de focar em protestos para tentar pressionar stakeholders e estados que são os maiores poluidores, eles reconheceram que a luta contra as mudanças climáticas levará a melhores resultados se mudarmos os nossos sistemas económicos e produtivos também no nosso quotidiano, mudando os nossos estilos de vida. Este artigo explora três tipos de ativismo de mudança climática expressos por meio da agricultura urbana (AU). Através de ‘proximidades’, ‘dissidência disruptiva’ e ‘governança urbana participativa’, este artigo analisa como a AU, como forma de ativismo de mudança climática no terreno, pode ajudar a agir, tomando exemplos ilustrativos de duas capitais verdes europeias: Bristol no Reino Unido e Lisboa em Portugal.

Recebido: 24/1/2022
Aceite: 21/6/2022