bluuebunny/crossref_metadata_2025_split huggingface dataset:
Medication adherence in women with IBD of childbearing age likely associated with disease knowledge
Authors: Laube Robyn , Selinger Christian , Leong Rupert W. 
Published: December 2022

Background: Medication adherence in inflammatory bowel disease (IBD) is crucial, particularly during pregnancy. Unplanned pregnancies are common; therefore, efforts to maximise adherence should not be restricted to pregnant women. Objectives: We aimed to assess medication adherence in women with IBD of childbearing age, regardless of their reproduction plans. Design: We performed a multi-centre pilot questionnaire study of women with IBD age 18–45 years. Methods: Survey questions included patient demographics, disease history, and validated assessments of IBD and pregnancy knowledge, medication adherence and quality of life. The primary outcome was rates and predictors of medication adherence. Results: In all, 72 women [58.3% Crohn’s disease (CD) and 37.5% ulcerative colitis] completed the survey. The median patient age was 30 years [interquartile range (IQR): 24.8–36.0) and 37.5% had children. Medication adherence was high (84%; median Medication Adherence Report Scale: 19.0/20; IQR: 17.0–20.0). Knowledge scores were adequate for both the Crohn’s and Colitis Knowledge (CCKnow; median: 15.5/30; IQR: 12.3–18.0) and Crohn’s and Colitis Pregnancy Knowledge (CCPKnow; median: 8.0/17; IQR: 4.0–11.0). Disease knowledge was predictive of high medication adherence (CCPKnow: p = 0.02; CCKnow: p ⩽ 0.01). Higher adherence was significantly associated with a diagnosis of CD ( p = 0.01), exposure to biological agents ( p = 0.03) and immunomodulators ( p = 0.04), childbearing after diagnosis with IBD ( p = 0.03), and correctly understanding the importance of delivery modality ( p = 0.02) and IBD activity in pregnancy ( p = 0.01). Conclusions: Following dedicated education at the IBD clinic, medication adherence, disease-specific and pregnancy-specific knowledge in women with IBD of childbearing age tends to be high. Unplanned pregnancies are frequent; therefore, we should aim to maximise medication adherence in all women of childbearing age to optimise maternofoetal outcomes if unexpected pregnancies occur.
Lumbar Multifidus Morphology in Youth Competitive Alpine Skiers and Associated Sex, Age, Biological Maturation, Trunk Stability, and Back Complaints
Authors: Fitze Daniel P. , Franchi Martino V. , Ellenberger Lynn , Peterhans Loris , Fröhlich Stefan , Frey Walter O. , Spörri Jörg 
Published: December 2022

Background: The lumbar multifidus (LMF), as a dynamic stabilizer of the lumbar spine, may play an important role in the prevention of overuse-related back complaints. Hypothesis: LMF morphology is associated with trunk stability and differs between symptomatic and asymptomatic skiers. Study Design: Cohort study. Level of Evidence: Level 3. Methods: A total of 85 youth skiers (28 females, mean age, 14.7 ± 0.7 years; 57 males, mean age, 14.9 ± 0.5 years) underwent anthropometric assessments, an estimation of biological maturation, a magnetic resonance imaging- and ultrasound-based examination of LMF morphology, and a biomechanical quantification of deadbug bridging stabilization performance. Athletes were categorized as symptomatic if they had registered at least 1 significant overuse-related back complaint episode in the 12 months before the main examination. Results: Male skiers showed a greater LMF size (ie, anatomical cross-sectional area [ACSA]) than female skiers, except for vertebral body L5, where no difference was found (8.8 ± 1.8 cm2 vs 8.3 ± 1.4 cm2, P = 0.18). Conversely, female skiers displayed longer fascicles than male skiers (5.8 ± 0.8 cm vs 5.4 ± 0.8 cm, P = 0.03). Skiers aged under 16 years (U16) skiers had greater values for LMF size and fascicle length than U15 skiers. Maturity offset was associated with L5 LMF size ( R2 = 0.060, P = 0.01), fascicle length ( R2 = 0.038, P = 0.04), and muscle thickness ( R2 = 0.064, P = 0.02). L5 LMF size was associated with trunk stability ( R2 = 0.068, P = 0.01). Asymptomatic skiers showed on average a 12.8% greater value for L5 LMF size compared with symptomatic skiers ( P = 0.04). Conclusion: There are sex- and age-related differences in LMF morphology in youth competitive alpine skiers. Moreover, the ACSA at the level of the lumbar vertebral body L5 undergoes changes during biological maturation, shows a small, but significant association with trunk stability, and differs between symptomatic and asymptomatic skiers with back complaints. Clinical Relevance: The observed association of muscle structure (ie, L5 LMF ACSA) with functional aspects (ie, trunk stabilization capacity) and clinical representation (ie, overuse-related back complaints) further highlights the important role of the multifidus muscle for training and injury prevention in youth competitive alpine skiers around the growth spurt.
What influences physician opioid prescribing for children with acute pain?
Authors: Slim George , van Manen Michael , Fowler Megan , Poonai Naveen , Ali Samina 
Published: December 2022

BackgroundPain is one of the most common symptoms encountered in the healthcare system, and opioids are among the top three medications used to treat it. Understanding the reasoning behind physicians’ opioid prescribing practices is vital to safe practice. The primary objective of our study was to describe pediatric emergency physicians’ decision-making process when prescribing opioids for children’s acute pain management.MethodsThis study employed qualitative methodology, using one-on-one semi-structured interviews within a grounded theory analytic framework. We employed purposeful sampling to recruit pediatric emergency physicians from across Canada. Interviews were conducted by telephone (December 2019–January 2021). Transcript analysis occurred concurrently with data collection, supporting data saturation and theory development considerations.ResultsEleven interviews were completed with participants representing each of Canada’s geographic regions. Nine major themes emerged: (1) practice setting and outpatient opioid use, (2) condition-specific considerations, (3) physician confidence in medical evidence, (4) pain assessment challenges, (5) patient and family perspectives, (6) opioid safety concerns, (7) personal biases and experiences, (8) personal practice context, and (9) the Opioid Crisis/media influence. Most clinicians felt that they limited opioid use to those who needed it most; all participants described challenges managing acute pain, emphasizing the need for accurate pain measurement and better guidelines, evidence-based data, and knowledge translation. Clinicians were more comfortable treating pain in the emergency department, compared to discharge prescribing. They recognized the importance of co-therapy with non-opioids and the need for opioid risk assessment when prescribing. A family centered approach was recognized as the goal of practice.ConclusionClinicians are less comfortable prescribing opioids to children for at-home use and find pain assessment and lack of clear guidelines to be barriers to pain care. Knowledge translation strategies for safer practice and optimal acute pain management could support responsible and judicious opioid use.
China Medical Education College Survey, 2013–2018
Authors: You (由由) You , Jia (贾娜丽) Nali , Xie (谢阿娜) Ana , Wang (王维民) Weimin 
Published: December 2022

Purpose China recently proposed a series of important policies intended to reform and improve the quality of medical education on the national level. This paper presents the findings of a national survey of China's medical schools conducted to review the development of undergraduate medical education over a five-year period (2013–2018). Design/Approach/Methods The National Center for Health Professions Education Development implemented the China Medical Education College Survey. Approximately 64% of the targeted medical schools participated in the survey, constituting a representative sample of higher education institutions offering educational programs in clinical medicine in China. Findings Following new policy orientations, medical schools showed positive developments in terms of the types of medical education programs offered, teaching and assessment methods, medical education resources, participation in accreditation, and quality of incoming students. However, the survey also revealed several worrying trends, including the coexistence of various types of education programs, significant regional differences in educational resources, dominance of traditional teaching and assessment methods, inconsistencies in quality, and an increase in graduates seeking employment in professions outside healthcare. Originality/Value Findings of the first national survey of China's medical schools show that there is still a long way to go to ensure high quality and efficient medical education on a national level.
Venetoclax treatment in patients with cancer has limited impact on circulating T and NK cells
Authors: Teh Charis E. , Peng Hongke , Luo Meng-Xiao , Tan Tania , Trussart Marie , Howson Lauren J. , Chua Chong Chyn , Muttiah Christine , Brown Fiona , Ritchie Matthew E. , Wei Andrew H. , Roberts Andrew W. , Bryant Vanessa L. , Anderson Mary Ann , Lindeman Geoffrey J. , Huang David C. S. , Thijssen Rachel , Gray Daniel H. D. 
Published: December 2022

Abstract
Venetoclax is an effective treatment for certain blood cancers, such as chronic lymphocytic leukemia (CLL) and acute myeloid leukemia (AML). However, most patients relapse while on venetoclax and further treatment options are limited. Combining venetoclax with immunotherapies is an attractive approach; however, a detailed understanding of how venetoclax treatment impacts normal immune cells in patients is lacking. In this study, we performed deep profiling of peripheral blood (PB) cells from patients with CLL and AML before and after short-term treatment with venetoclax using mass cytometry (cytometry by time of flight) and found no impact on the concentrations of key T-cell subsets or their expression of checkpoint molecules. We also analyzed PB from patients with breast cancer receiving venetoclax long-term using a single-cell multiomics approach (cellular indexing of transcriptomes and epitopes by sequencing) and functional assays. We found significant depletion of B-cell populations with low expression of MCL-1 relative to other immune cells, attended by extensive transcriptomic changes. By contrast, there was less impact on circulating T cells and natural killer (NK) cells, with no changes in their subset composition, transcriptome, or function following venetoclax treatment. Our data indicate that venetoclax has minimal impact on circulating T or NK cells, supporting the rationale of combining this BH3 mimetic drug with cancer immunotherapies for more durable antitumor responses.
Molecular barcoding of Melissa officinalis L. (badranjboye) in Iran and identification of adulteration in its medicinal services
Authors: Koohdar Fahimeh , Sheidai Masoud 
Published: December 2022

AbstractMedicinal plants are an important source for treatment of diseases in many countries. Today, controlling the quality of the products of medicinal plants is an important task. Customer health may be in danger due to the fraud and misconduct by the sales associates in the sales centers. Melissa officinalis L. (Lamiaceae) is an important medicinal plant used for treatment of several diseases. In Iran, the species of Dracocephalum, Hymencrater, Nepeta and Stachys are mistakenly sold under the name of Badranjboye that have different pharmaceutical properties. For avoiding this mistake, this investigation was performed with the following aims: 1) Checking for the cheating and identifying the Badranjboye in the Iran’s market of medicinal plants, 2) Providing the molecular barcode for the medicinal species of Melissa. For this purpose, Market-sold plant samples (leaves) and original reference plant species were compared by morphology, odor as well as Internal transcribed spacer (ITS) and chloroplast DNA ((psbA–trnH) and (trnL–trnF)) sequences. Various molecular analyses, such as sequencing, determination of genetic distance, and construction of phylogenetic tree were performed. These reports have shown that internal transcribed spacer (ITS) and chloroplast DNA (psbA–trnH) sequences are an efficient molecular marker to produce barcode gap and differentiating Melissa officinalis from other species.
The effect of positive end-expiratory pressure on intracranial pressure in obese and non-obese severe brain injury patients: a retrospective observational study
Authors: Zhou Dawei , Li Tong , Fei Shuyang , Wang Chao , Lv Yi 
Published: December 2022

Abstract
Background
The effect of positive end-expiratory pressure (PEEP) on intracranial pressure (ICP) had never been studied in obese patients with severe brain injury (SBI). The main aim was to evaluate the effect of PEEP on ICP in SBI patients with mechanical ventilation according to obesity status.

Methods
SBI patients admitted to the ICU with mechanical ventilation between 2014 and 2015 were included. Demographic, hemodynamic, arterial blood gas, and ventilator data at the time of the paired PEEP and ICP observations were recorded and compared between obese (body mass index ≥ 30 kg/m2) and non-obese SBI patients. Generalized estimating equation (GEE) model was used to assess the relationship between PEEP and ICP in obese and non-obese SBI patients, respectively.

Results
Six hundred twenty-seven SBI patients were included, 407 (65%) non-obese and 220 (35%) obese patients. A total of 30,415 paired PEEP and ICP observations were recorded in these patients, 19,566 (64.3%) for non-obese and 10,849 (35.7%) for obese. In the multivariable analysis, a statistically significant relationship between PEEP and ICP was found in obese SBI patients, but not in non-obese ones. For every cmH2O increase in PEEP, there was a 0.19 mmHg increase in ICP (95% CI [0.05, 0.33], P = 0.007) and a 0.15 mmHg decrease in CPP (95% CI [-0.29, -0.01], P = 0.036) in obese SBI patients after adjusting for confounders.

Conclusions
The results suggested that, contrary to non-obese SBI patients, the application of PEEP may produce an increase in ICP in obese SBI patients. However, the effect was modest and may be clinically inconsequential.
Psychometric properties of the Arabic version of the Oviedo Grit Scale (A-EGO) in non-clinical adults from the general population
Authors: Fekih-Romdhane Feten , Postigo Álvaro , González-Nuevo Covadonga , Dabbous Mariam , Malaeb Diana , Obeid Sahar , Hallit Souheil 
Published: December 2022

Abstract
Background
Given the high clinical utility of grit, and the lack of measures that assess this construct among the Arabic-speaking populations, we propose to examine the psychometric properties of an Arabic translation of the Oviedo Grit Scale (A-EGO) in terms of internal consistency, factor structure, convergent validity, and measurement invariance in a sample of Lebanese adults from the general population.

Methods
We performed a cross-sectional, online study among 575 participants from the Lebanese general population (mean age = 26.28 years [SD: 8.83], 72.7% females). The unidimensional factorial structure of the A-EGO was analyzed by confirmatory factor analysis (CFA) using the MPlus8 program. The mean and variance adjusted weighted least squares (WLSMV) was used as the estimation method. The reliability of the scores, the evidence of validity in terms of measurement invariance and correlation with other variables were analyzed.

Results
The present results show that the 10 items of the A-EGO loaded on one factor. The internal consistency was excellent in our sample, as evidenced by a Cronbach’s alpha value of .93. Multi-group confirmatory factor analyses demonstrated invariance across gender, governorate, and marital status at the configural, metric and scalar levels. Additionally, A-EGO scores showed moderate and positive correlations with self-control (r = .442), conscientiousness (r = .478), and productiveness facet (r = .506), supporting the convergent validity of the A-EGO.

Conclusion
Our findings indicate that the A-EGO has good psychometric properties and can be recommended for the assessment of grit among the broader Arabic-speaking people worldwide. Making this scale available in the Arabic language will hopefully foster research in this area in Arab countries.
Co-development of an evidence-based personalised smoking cessation intervention for use in a lung cancer screening context
Authors: Quinn-Scoggins Harriet D. , Murray Rachael L. , Quaife Samantha L. , Smith Pamela , Brain Kate E. , Callister Matthew E. J. , Baldwin David R. , Britton John , Crosbie Philip A. J. , Thorley Rebecca , McCutchan Grace M. 
Published: December 2022

AbstractBackgroundOptimising smoking cessation services within a low radiation-dose computed tomography (LDCT) lung cancer screening programme has the potential to improve cost-effectiveness and overall efficacy of the programme. However, evidence on the optimal design and integration of cessation services is limited. We co-developed a personalised cessation and relapse prevention intervention incorporating medical imaging collected during lung cancer screening. The intervention is designed to initiate and support quit attempts among smokers attending screening as part of the Yorkshire Enhanced Stop Smoking study (YESS: ISRCTN63825779). Patients and public were involved in the development of an intervention designed to meet the needs of the target population.MethodsAn iterative co-development approach was used. Eight members of the public with a history of smoking completed an online survey to inform the visual presentation of risk information in subsequent focus groups for acceptability testing. Three focus groups (n = 13) were conducted in deprived areas of Yorkshire and South Wales with members of the public who were current smokers or recent quitters (within the last year). Exemplar images of the heart and lungs acquired by LDCT, absolute and relative lung cancer risk, and lung age were shown. Data were analysed thematically, and discussed in stakeholder workshops. Draft versions of the intervention were developed, underpinned by the Extended Parallel Processing Model to increase self-efficacy and response-efficacy. The intervention was further refined in a second stakeholder workshop with a patient panel.ResultsIndividual LDCT scan images of the lungs and heart, in conjunction with artistic impressions to facilitate interpretation, were considered by public participants to be most impactful in prompting cessation. Public participants thought it important to have a trained practitioner guiding them through the intervention and emphasising the short-term benefits of quitting. Presentation of absolute and relative risk of lung cancer and lung age were considered highly demotivating due to reinforcement of fatalistic beliefs.ConclusionAn acceptable personalised intervention booklet utilising LDCT scan images has been developed for delivery by a trained smoking cessation practitioner. Our findings highlight the benefit of co-development during intervention development and the need for further evaluation of effectiveness.
Relapse in class II orthognathic surgery: a systematic review
Authors: Eckmüller Stephanie , Paddenberg Eva , Hiller Karl-Anton , Proff Peter , Knüttel Helge , Kirschneck Christian 
Published: December 2022

Abstract
Objectives
Relapse after orthognathic surgery seems to depend on diverse factors. Proffit et al. postulated in 2007 a “hierarchy of stability” (Head Face Med 6:66, 2007), ranking posttreatment stability after various orthognathic procedures, but no systematically reviewed evidence was provided. Therefore, the aim of this review was to investigate the extent of class II relapse in orthognathic surgery of Angle class II patients depending on the surgical procedure used.

Materials and methods
Seven databases were searched for randomized and controlled clinical trials to compare relapse in surgical procedures for Angle class II patients. After duplicate study selection, data extraction and risk of bias assessment were performed with the ROBINS-I tool as well as data synthesis by frequency distribution, followed by assessment of the quality of evidence with GRADE.

Results
Four non-randomized cohort-studies with a total of 132 patients were included. Bimaxillary procedures as well mandibular advancement procedures proved to be highly stable. Single jaw interventions at the maxilla achieved mostly stable results at sagittal dimension and problematic stability in the vertical dimension. However, there were only limited data available with low quality of evidence.

Conclusions
Limited existing evidence of low quality partly support the postulated hierarchy of stability of Proffit et al. (Head Face Med 6:66, 2007) and indicates that a surgical correction of class II dysgnathia with bimaxillary procedures and mandibular advancement seems to be highly stable. However, additional studies are needed to address the relation between relapse and surgical orthognathic intervention.
Trial registration PROSPERO 2019 CRD42019144873.
The societal impact of implementing an at-home blood sampling device for chronic care patients: patient preferences and cost impact
Authors: Lingervelder Deon , Kip Michelle M. A. , Wiese Eva D. , Koffijberg Hendrik , Ijzerman Maarten J. , Kusters Ron 
Published: December 2022

Abstract
Background
Diabetes mellitus, cardiovascular diseases, chronic kidney disease, and thyroid diseases are chronic diseases that require regular monitoring through blood tests. This paper first investigates the experiences of chronic care patients with venipuncture and their expectations of an at-home blood-sampling device, and then assesses the impact on societal costs of implementing such a device in current practice.

Methods
An online survey was distributed among chronic care patients to gain insight into their experience of blood sampling in current practice, and their expectations of an at-home blood-sampling device. The survey results were used as input parameters in a patient-level monte carlo analysis developed to represent a hypothetical cohort of Dutch chronically ill patients to investigate the impact on societal costs compared to usual care.

Results
In total, 1311 patients participated in the survey, of which 31% experience the time spent on the phlebotomy appointment as a burden. Of all respondents, 71% prefer to use an at-home blood-sampling device to monitor their chronic disease. The cost analysis indicated that implementing an at-home blood-sampling device increases the cost of phlebotomy itself by €27.25 per patient per year, but it reduces the overall societal costs by €24.86 per patient per year, mainly due to limiting productivity loss.

Conclusions
Patients consider an at-home blood-sampling device to be more user-friendly than venous phlebotomy on location. Long waiting times and crowded locations can be avoided by using an at-home blood-sampling device. Implementing such a device is likely cost-saving as it is expected to reduce societal costs.