bluuebunny/crossref_metadata_2025_split huggingface dataset:
Globefish‐Inspired Balloon Catheter with Intelligent Microneedle Coating for Endovascular Drug Delivery
Authors: Zhang Xiaoxuan , Cheng Yi , Liu Rui , Zhao Yuanjin 
Published: October 2022

AbstractBalloon catheters exhibit important values in treating cardiovascular diseases, while their functions are still under improvements. Here, inspired by the thorn‐hiding and deflating–inflating characteristics of globefish, intelligent balloon catheters decorated with invisible microneedles are presented for endovascular drug delivery to inhibit postintervention restenosis (PIRS). These microneedle balloon catheters (MNBCs) fabricated by dipping and rolling‐assisted template replication contain three coating layers of sandwiched drug‐carrying microneedles and black phosphorus (BP)‐carrying gelatin. During the emplacement, the microneedles of MNBCs are hidden under the outermost gelatin protective layer, allowing smooth movements inside the blood vessel. After reaching the destination, the embedded BP converts near infrared (NIR) into heat, increases local temperature, and melts the gelatin layer, enabling the exposure and vascular penetration of the microneedles. Besides, as the innermost gelatin also melts, the microneedles can detach from the balloon catheter and be left inside the blood vessel for continuous drug release. Based on advantages of responsiveness, penetration capacity, and biosafety, it is demonstrated that the MNBCs behave satisfactorily in delivering rapamycin to inhibit abdominal aorta restenosis in rats. All these features indicate that these MNBCs are promising medical devices for clinical applications.
Predictors of impaired antibody response after SARS‐CoV‐2 mRNA vaccination in hematopoietic cell transplant recipients: A Japanese multicenter observational study
Authors: Mori Yasuo , Uchida Naoyuki , Harada Takuya , Katayama Yuta , Wake Atsushi , Iwasaki Hiromi , Eto Tetsuya , Morishige Satoshi , Fujisaki Tomoaki , Ito Yoshikiyo , Kamimura Tomohiko , Takahashi Tsutomu , Imamura Yutaka , Tanimoto Kazushi , Ishitsuka Kenji , Sugita Junichi , Kawano Noriaki , Tanimoto Kazuki , Yoshimoto Goichi , Choi Ilseung , Hidaka Tomonori , Ogawa Ryosuke , Takamatsu Yasushi , Miyamoto Toshihiro , Akashi Koichi , Nagafuji Koji 
Published: October 2022

AbstractHCT recipients reportedly have a high mortality rate after developing COVID‐19. SARS‐CoV‐2 vaccination is generally useful to prevent COVID‐19. However, its safety and efficacy among HCT recipients remain elusive. This large‐scale prospective observational study including 543 HCT recipients with 37‐months interval from transplant demonstrated high safety profiles of mRNA vaccine: only 0.9% of patients avoided the second dose due to adverse event or GVHD aggravation following the first dose. Regarding the efficacy, serological response with a clinically relevant titer (≥250 BAU/mL) was obtained in 397 (73.1%) patients. We classified the remaining 146 patients as impaired responders and compared the clinical and immunological parameters between two groups. In allogeneic HCT recipients, multivariable analysis revealed the risk factors for impaired serological response as follows: age (≥60, 1 points), HLA‐mismatched donor (1 points), use of systemic steroids (1 points), absolute lymphocyte counts (<1000/μL, 1 points), absolute B‐cell counts (<100/μL, 1 points), and serum IgG level (<500 mg/dL, 2 points). Notably, the incidence of impaired serological response increased along with the risk scores: patients with 0, 1–3, and 4–7 points were 3.9%, 21.8%, and 74.6%, respectively. In autologous HCT recipients, a shorter interval from transplant to vaccination was the only risk factor for impaired serological response. Our findings indicate that two doses of SARS‐CoV‐2 vaccine are safe but insufficient for a part of HCT recipients with higher risk scores. To improve this situation, we should consider additional treatment options, including booster vaccination and prophylactic neutralizing antibodies during the SARS‐CoV‐2 pandemic.
Platinum‐Based TREM2 Inhibitor Suppresses Tumors by Remodeling the Immunosuppressive Microenvironment
Authors: Yang Tao , Zhang Shuren , Yuan Hao , Wang Ying , Cai Linxiang , Chen Hanhua , Wang Xiaoyu , Song Dongfan , Wang Xiaohui , Guo Zijian , Wang Xiaoyong 
Published: October 2022

AbstractTriggering receptor expressed on myeloid cells‐2 (TREM2) is a key pro‐tumorigenic marker of tumor‐infiltrating macrophages, showing potent immunosuppressive activity in tumor microenvironment. A platinum(IV) complex OPA derived from oxaliplatin (OP) and artesunate (ART) exhibited direct cytotoxicity against human colon cancer cells and immunomodulatory activity to inhibit TREM2 on macrophages in vitro and vivo. Furthermore, OPA deterred the tumor growth in mouse models bearing MC38 colorectal tumor by reducing the number of CD206+and CX3CR1+immunosuppressive macrophages; it also promoted the expansion and infiltration of immunostimulatory dendritic, cytotoxic T, and natural killer cells. OPA is the first small‐molecular TREM2 inhibitor capable of relieving immunosuppressive tumor microenvironment and enhancing chemical anticancer efficiency of a platinum drug, thus showing typical characteristics of a chemoimmunotherapeutic agent.
Ultra‐Tight Host‐Guest Binding with Exceptionally Strong Positive Cooperativity
Authors: Sobiech Thomas A. , Zhong Yulong , Miller Daniel P. , McGrath Jillian K. , Scalzo Christina T. , Redington Morgan C. , Zurek Eva , Gong Bing 
Published: October 2022

AbstractCooperativity plays a critical role in self‐assembly and molecular recognition. A rigid aromatic oligoamide macrocycle with a cyclodirectional backbone binds with DABCO‐based cationic guests in a 2 : 1 ratio in high affinities (Ktotal≈1013 M−2) in the highly polar DMF. The host–guest binding also exhibits exceptionally strong positive cooperativity quantified by interaction factors α that are among the largest for synthetic host–guest systems. The unusually strong positive cooperativity, revealed by isothermal titration calorimetry (ITC) and fully corroborated by mass spectrometry, NMR and computational studies, is driven by guest‐induced stacking of the macrocycles and stabilization from the alkyl end chains of the guests, interactions that appear upon binding the second macrocycle. With its tight binding driven by extraordinary positive cooperativity, this host–guest system provides a tunable platform for studying molecular interactions and for constructing stable supramolecular assemblies.
A green extraction process of nanocarbon dots from prawn shells, and its reinforcement in epoxy polymers
Authors: Ashraf Pachareentavita Muhamed , Anju Vadakkanethu Sadasivan , Binsi Puthenpurakkal Kizhakkethil , Joseph Toms Cheriyath 
Published: October 2022

AbstractExoskeletons of prawn, shrimp, and crab discarded as waste are rich sources of inorganic and organic materials. Currently, these discards are mainly utilized for the extraction of chitin and less attention is paid to the recovery of other organic constituents present in the exoskeletons. The present study aimed to synthesize nano carbon dot (CD) and chitin from prawn shell, and utilization of CD as an additive to epoxy polymers to obtain a corrosion resistant polymer coating. Nano CDs were synthesized through a hydrothermal carbonization process and the characteristics were evaluated using spectrophotometric, fluorescence, and Fourier transform infrared spectroscopy studies. The CD reinforced bisphenol epoxy polymer composite coated over boat building steel exhibited the least defect, which in turn imparted the highest polarization resistance with the lowest capacitance. Chemical and morphological data of epoxy polymer composite highlighted the interaction of NH2 present in CD with polymer matrix. The functional group NH2 from CD synergistically acted along with hardener to form a pore free epoxy coating. Hydrothermal process of prawn shell enabled to extract chitin as evidenced by their spectral signature peaks. This study gave two economically important products through a green synthesis protocol.
Assessing the learning of pupils with special educational needs and disabilities in mainstream school physical education
Authors: Maher Anthony , van Rossum Tom , Morley David 
Published: October 2022

AbstractIn the UK, one consequence of neoliberalism has been the development of test cultures in schools and standardised assessment strategies used to judge all pupils against within and across curriculum subjects. Few studies to date have explored the influence of this on assessing the learning of pupils with special educational needs and disabilities (SEND), and none have centred physical education (PE). This study used the concept of ableism and semi‐structured interviews to explore mainstream secondary school PE teachers’ views and experiences of assessing the learning of pupils with SEND. Based on the findings, we discuss the importance of schools disrupting hegemonic, ableist modes of thinking that cast pupils with SEND as being of inferior ability when compared with their peers and thus being disadvantaged by standardised, normative assessment practices. Specifically, we identify a need for senior leaders and teachers in schools to recognise the needs and capabilities of pupils with SEND, through more holistic assessment approaches that focus on social, affective, cognitive and physical learning and development. We end by discussing the significance of initial teacher education and teacher networks to support this endeavour and advocating for the amplification of the voices of pupils with SEND, given that they have expert knowledge about the perceived inclusivity of assessment in PE because they can draw upon their lived and embodied experiences.
Structural brain abnormalities in endothelial nitric oxide synthase‐deficient mice revealed by high‐resolution magnetic resonance imaging
Authors: George Hannah , Mercer Grace V. , Stapleton Darcie , Dawson Laura , MacCallum Phillip E. , Spring Shoshana , Sled John G. , Blundell Jacqueline , Cahill Lindsay S. 
Published: October 2022

AbstractIntroductionEndothelial nitric oxide synthase (eNOS) produces nitric oxide, which is essential for a variety of physiological functions in the brain. Previous work has demonstrated the detrimental effects of eNOS deficiency on brain function in male eNOS knockout (eNOS KO) mice. However, the effect of eNOS deficiency on brain structure and any association between these effects and sex is unknown.MethodsThis study used three‐dimensional high‐resolution ex vivo magnetic resonance imaging and behavioral tests of anxiety and cognitive performance to investigate structure–function relationships in the brain of female and male eNOS KO mice in young adulthood.ResultsWhile there were no differences in anxiety‐like behavior or locomotion, there was a sex‐specific deficit in contextual fear memory retention in male, but not in female, eNOS mice compared to wild‐type controls. Moreover, we found that eNOS deficiency induced changes in multiple brain regions that are involved in learning and fear memory including the hippocampus, amygdala, hypothalamus, and areas of the cortex. Several of these MRI‐detectable neuroanatomical changes were dependent on sex.ConclusionThe observation that eNOS deficiency impacts brain structure at an early age demonstrates the importance of eNOS for healthy brain development.
The diagnosis, classification, and treatment of sarcoma in this era of artificial intelligence and immunotherapy
Authors: Crombé Amandine , Roulleau‐Dugage Mathtieu , Italiano Antoine 
Published: October 2022

AbstractSoft‐tissue sarcomas (STS) represent a group of rare and heterogeneous tumors associated with several challenges, including incorrect or late diagnosis, the lack of clinical expertise, and limited therapeutic options. Digital pathology and radiomics represent transformative technologies that appear promising for improving the accuracy of cancer diagnosis, characterization and monitoring. Herein, we review the potential role of the application of digital pathology and radiomics in managing patients with STS. We have particularly described the main results and the limits of the studies using radiomics to refine diagnosis or predict the outcome of patients with soft‐tissue sarcomas. We also discussed the current limitation of implementing radiomics in routine settings. Standard management approaches for STS have not improved since the early 1970s. Immunotherapy has revolutionized cancer treatment; nonetheless, immuno‐oncology agents have not yet been approved for patients with STS. However, several lines of evidence indicate that immunotherapy may represent an efficient therapeutic strategy for this group of diseases. Thus, we emphasized the remarkable potential of immunotherapy in sarcoma treatment by focusing on recent data regarding the immune landscape of these tumors. We have particularly emphasized the fact that the development of immunotherapy for sarcomas is not an aspect of histology (except for alveolar soft‐part sarcoma) but rather that of the tumor microenvironment. Future studies investigating immunotherapy strategies in sarcomas should incorporate at least the presence of tertiary lymphoid structures as a stratification factor in their design, besides including a strong translational program that will allow for a better understanding of the determinants involved in sensitivity and treatment resistance to immune‐oncology agents.
Bioactive Secondary Plant Metabolites from Euphorbia umbellata (PAX) BRUYNS (Euphorbiaceae)
Authors: Latansio de Oliveira Thais , Reder Custodio de Souza Ariádine , Dias Fontana Pâmela , Carvalho Carneiro Milena , Beltrame Flávio Luís , de Messias Reason Iara Jose , Bavia Lorena 
Published: October 2022

AbstractThe species Euphorbia umbellata has been used to treat inflammatory diseases, cancer, and ulcers. Biological activities reported in the literature, including antiproliferative, cytotoxic and anti‐inflammatory, are attributed to the chemical constituents present in its composition as terpenes and polyphenolic compounds. The most recurrently verified metabolites in the Euphorbiaceae family plant species are terpenes, of which euphol is a major constituent with broadly reported cytotoxic, antinociceptive and anti‐inflammatory effects; it frequently appears in various extracts obtained from the plant. Euphol has a documented inhibitory effect on neutrophil chemotaxis and can modulate the complement system. Since complement system activation is intimately intertwined with autoimmune and inflammatory diseases, tumor growth promotion and metastasis, plant metabolites from Euphorbia umbellata might influence the outcomes of inflammatory processes. We believe that this is the first review presenting the current knowledge on Euphorbia umbellata secondary metabolites and their biological activities.
Impact of intracoronary assessments on revascularization decisions: A contemporary evaluation
Authors: Gillmore Taylor , Jung Richard G. , Moreland Robert , Di Santo Pietro , Stotts Cameron , Makwana Dwipen , Abdel‐Razek Omar , Ahmed Zeeshan , Chung Kevin , Parlow Simon , Simard Trevor , Froeschl Michael , Labinaz Marino , Hibbert Benjamin 
Published: October 2022

AbstractObjectivesTo investigate the real‐world implementation of intracoronary assessment (ICA) techniques and evaluate their impact on clinical decisions regarding the management of coronary artery disease (CAD) in contemporary practice.BackgroundCoronary angiogram is the gold standard used to diagnose vessel stenosis and guide percutaneous coronary intervention (PCI); however, it is limited by its two‐dimensional imaging capabilities. ICA techniques like intravascular ultrasound and optical coherence tomography capture the vessel in three‐dimensional images. Comparatively, fractional flow reserve provides information on the physiologic significance of coronary stenosis. Both techniques may improve PCI outcomes if they routinely change physician behavior.MethodsPatients who underwent ICA between August 2015 and March 2020 were included in the study. The primary outcome was the clinical impact of ICA on physician clinical decision making of a stenotic vessel. The secondary outcome was the clinical changes that occurred following ICA.ResultsA total of 1135 patients were included in the study. Physiologic assessment (PA) and image assessment (IA) were performed in 61.4% and 38.6% respectively. Management plans were changed in 38.1% and 23.9% of patients who received PA and IA. Over half of the management change resulted in physicians deciding to not intervene on the stenotic vessel. One‐year outcome of these decisions showed no significant increase in major adverse cardiac events (hazard ratio [HR], 0.68; 95% confidence interval [CI], 0.40–1.15; p = 0.15) or unplanned revascularization (HR, 0.78; 95% CI, 0.35–1.74; p = 0.55) suggesting reliance on PA/IA data did not increase risk.ConclusionSelected ICA alters physician management of CAD in one‐third of patients being evaluated for revascularization—typically leading to fewer interventions. All cause death is numerally lower in patients that received a change in management. However, the 1‐year outcome of these altered decisions does not appear to be significantly different.
Child and adolescent career construction: Lived experiences of an expressive arts group
Authors: Lindo Natalya A. , Li Dan , Hastings Tessa , Ceballos Peggy , Werts Rebecca , Molina Citlali , Oller Marianna , Laird Amber 
Published: October 2022

AbstractThe Child and Adolescent Career Construction Interview (CACCI), adapted from the Career Construction Interview, is a comprehensive career counseling intervention tailored to meet the developmental needs of children and adolescents, and is especially designed to address preadolescent needs in career and social/emotional domains. Because of the dearth of child and adolescent career development research, unique career development needs of preadolescent girls, and potential benefits of a gender homogenous group intervention, the purpose of this phenomenological study was to examine preadolescent girls’ lived experiences of participating in a CACCI group. Findings of this study have the potential to inform developmentally appropriate career counseling for preadolescents. Through the CACCI, counselors can help preadolescents explore their conception of self and their approach to decision‐making and problem‐solving. By adopting a present‐focused approach, counselors facilitate preadolescents’ development of self‐awareness in the “here and now,” laying the foundation for future self‐exploration as they move through adolescent development.
Froth flotation as primary treatment of flowback water: Removal of total organic carbon and prediction of kinetics
Authors: Sinha Shikha , Roy Debashis , Sengupta Sourav , Neogi Sudarsan , De Sirshendu 
Published: October 2022

AbstractPetroleum and exploration industries employ a hydrofracking process where a large volume of water (fracturing fluid) is injected and a fraction (known as flowback water) is returned to the surface. Froth flotation is a typical process employed for the primary treatment of water. In the present work, froth flotation has been used as a pretreatment method for real flowback water sourced from the petroleum and shale gas exploration industry. In the present work, a first‐principle based convective mass transfer model has been developed to describe the froth flotation performance. The resultant equation was solved analytically and compared with the numerical solution, and a parametric sensitivity analysis of the process performance was also undertaken. In addition, a correlation to estimate the flotation rate constant was proposed, thereby circumventing the need to obtain a large number of cumbersome parameters experimentally. Overall, this study proposes froth flotation as an efficient primary treatment method towards the separation of dispersed oil droplets from the flowback water and the corresponding prediction of kinetics using a first‐principle based transport model.
Impact of patient choice and hospital competition on patient outcomes after rectal cancer surgery: A national population‐based study
Authors: Han Lu , Boyle Jemma M. , Walker Kate , Kuryba Angela , Braun Michael S. , Fearnhead Nicola , Jayne David , Sullivan Richard , van der Meulen Jan , Aggarwal Ajay 
Published: October 2022

AbstractBackgroundThe objective of the current national cohort study was to analyze the correlation between choice and competition on outcomes after cancer surgery in rectal cancer.MethodsThe analysis included all men who underwent rectal cancer surgery in the English National Health Service between March 2015 and April 2019 (n = 13,996). Multilevel logistic regression was used to assess the effect of a rectal cancer surgery center being located in a competitive environment (based on the number of centers within a threshold distance) and being a successful competitor (based on the ability to attract patients from other hospitals) on eight patient‐level outcomes: 30‐ and 90‐day emergency readmissions, 30‐day re‐operation rates, 90‐day postoperative mortality, length of stay >14 days, circumferential resection margin status, rates of primary procedure with a permanent stoma, and rates of persistent stoma 18 months after anterior resection.ResultsWith adjustment for patient characteristics, patients who underwent surgery in centers located in a stronger competitive environment were less likely to have an abdominoperineal excision or a Hartman's procedure (odds ratio [OR], 0.73; 95% confidence interval [CI], 0.55–0.97, p = .04). Additionally, individuals who received treatment at hospitals that were successful competitors had a lower risk of a 90‐day readmission following rectal cancer surgery (OR, 0.86; 95% CI, 0.76–0.97, p = .03) and were less likely to have a persistent stoma at 18 months after anterior resection (OR, 0.75; 95% CI, 0.61–0.93, p = .02).ConclusionsHospitals located in areas of high competition are associated with better patient outcomes and improved processes of care for rectal cancer surgery.
OCTRA‐5G: Osmotic computing based task scheduling and resource allocation framework for 5G
Authors: Kaur Akashdeep , Kumar Rajesh , Saxena Sharad 
Published: October 2022

SummaryLong term evolution (LTE) mobile technology provides high data rate and low latency. 5G Technology is capable of handling the increasing number of IoT devices and provides ultra‐low latency, higher throughput, and higher reliability. Mobile edge computing (MEC) a key 5G technology strengthens the real‐time processing ability, releases the load on the Core Network, and helps in the real‐time processing of data, fulfilling the promise of high data rate and low latency. MEC is used to manage services efficiently to the near user resource. Using Osmotic Computing the services are efficiently scheduled and migrated. The work presented in this article proposes OCTRA‐5G Framework to effectively schedule services and allocate resources using Osmotic Computing (OC) by segregating the services into microservices and macroservices. The results are validated on the sets of 10, 20, and 30 gNBs (base stations) through simulation. OCTRA‐5G is tested on First Come First Serve (FCFS), Priority Scheduling (PS), and Shortest Job First (SJF) algorithm. FCFS provides less time complexity and higher throughput. The results presented using numerical simulations shows better performance by an average of 66.921% with OC than without OC.