bluuebunny/crossref_metadata_2025_split huggingface dataset:
Genome-Wide Association Study of Adhesive Capsulitis Suggests Significant Genetic Risk Factors
Authors: Kulm Scott , Langhans Mark T. , Shen Tony S. , Kolin David A. , Elemento Olivier , Rodeo Scott A. 
Published: October 2022

Background:
Adhesive capsulitis of the shoulder involves loss of passive range of motion with associated pain and can develop spontaneously, with no obvious injury or inciting event. The pathomechanism of this disorder remains to be elucidated, but known risk factors for adhesive capsulitis include diabetes, female sex, and thyroid dysfunction. Additionally, transcriptional profiling and pedigree analyses have suggested a role for genetics. Identification of elements of genetic risk for adhesive capsulitis using population-based techniques can provide the basis for guiding both the personalized treatment of patients based on their genetic profiles and the development of new treatments by identification of the pathomechanism.

Methods:
A genome-wide association study (GWAS) was conducted using the U.K. Biobank (a collection of approximately 500,000 patients with genetic data and associated ICD-10 [International Classification of Diseases, 10th Revision] codes), comparing 2,142 patients with the ICD-10 code for adhesive capsulitis (M750) to those without. Separate GWASs were conducted controlling for 2 of the known risk factors of adhesive capsulitis—hypothyroidism and diabetes. Logistic regression analysis was conducted controlling for factors including sex, thyroid dysfunction, diabetes, shoulder dislocation, smoking, and genetics.

Results:
Three loci of significance were identified: rs34315830 (in WNT7B; odds ratio [OR] = 1.28; 95% confidence interval [CI], 1.22 to 1.39), rs2965196 (in MAU2; OR = 1.67; 95% CI, 1.39 to 2.00), and rs1912256 (in POU1F1; OR = 1.22; 95% CI, 1.14 to 1.31). These loci retained significance when controlling for thyroid dysfunction and diabetes. The OR for total genetic risk was 5.81 (95% CI, 4.08 to 8.31), compared with 1.70 (95% CI, 1.18 to 2.36) for hypothyroidism and 4.23 (95% CI, 2.32 to 7.05) for diabetes.

Conclusions:
The total genetic risk associated with adhesive capsulitis was significant and similar to the risks associated with hypothyroidism and diabetes. Identification of WNT7B, POU1F1, and MAU2 implicates the Wnt pathway and cell proliferation response in the pathomechanism of adhesive capsulitis.

Level of Evidence:
Prognostic Level III. See Instructions for Authors for a complete description of levels of evidence.
A Comprehensive and Low-Cost Wellbore Tubing and Pipeline Inspection Tool Using Electromagnetic Coupling and Machine Learning
Authors: Mostafa Tarek M. , Ooi Guang , Khater Moutazbellah , Ozakin Mehmet , Zeghlache Mohamed Larbi , Bagci Hakan , Ahmed Shehab 
Published: October 2022

Abstract
This work provides an advanced prototype for pipeline and wellbore tube inspection using electromagnetic (EM) resonance coupling, electromagnetic (EM) coupling, and machine learning. Utilizing only two transmitters and eight sensor coils, the described device can detect and characterize inner, outer, and total metal loss in a pipe's body. A defect in the pipe body alters the impedance of the transmitter and receiver coils and the mutual coupling between them, resulting in a relative change in one or more Rx outputs. A framework for artificial neural networks (ANN) is designed to assess the eight outputs and generate a two-dimensional map of the pipe cross-section. The ANN is trained using a finite-difference time-domain electromagnetic forward solver. The designed prototype is tested and validated through simulations and an experimental setup. The results demonstrate that the tool, with the assistance of the ANN, could not only detect single and double flaws with either complete or partial metal loss, but also define the defect's size, location, and depth.
In-situ buried interface passivation enables efficient and stable inverted perovskite solar modules
Authors: Li Lin , Zeng Haipeng , Wei Mingyang , Carnevali Virginia , Li Min , Lempesis Nikolaos , Eickemeyer Felix , Luo Long , Agosta Lorenzo , Dankl Mathias , Zakeeruddin Shaik , Rong Yaoguang , Rothlisberger Ursula , Graetzel Michael , Li Xiong 
Published: October 2022

Abstract
Scaling-up perovskite solar cells (PSCs) is a prerequisite to the adoption of perovskite photovoltaics. However, the performance and stability of perovskite solar modules (PSMs) have lagged behind those of lab-scale PSCs. The development of PSMs requires interfacial passivation, yet this is challenging for the buried interface, owing to the dissolution of passivation agents during perovskite deposition. Here, we overcome this limitation with in-situ buried interface passivation – achieved via directly adding a cyanoacrylic acid-based molecular additive, namely BT-T, into the perovskite precursor solution. Classical and ab-initio molecular dynamics (MD) simulations reveal that BT-T spontaneously self-assembles at the buried interface during perovskite film formation. The preferential buried interface passivation results in facilitated hole transfer and suppressed surface recombination. In addition, residual BT-T molecules in the perovskite layer enhance its stability and homogeneity. We report a power-conversion efficiency (PCE) of 20.3% for inverted-structure PSMs. The encapsulated PSM retains 92.5% of its initial PCE (20.2%) following 1817 h maximum power point (MPP) tracking under light illumination at 65 °C, corresponding to a T80 (time to 80% of initial PCEs) of 4500 h. Our demonstration of operating-stable PSMs under accelerated ageing represents a step closer to the commercialization of this emerging technology.
Interference Aware Routing in Dynamic Mobile Adhoc Network With the Concern of Qos Factors in Military Information System
Authors: Vignesh V. , Elngar Ahmed A. , Gopalan Harihara 
Published: October 2022

Abstract
Military communications or military signals are involved with every aspect of communications, or the information transmission, by the military services. The capability for the receipt and usage of information holds high importance on the battlefield. MANETs (Mobile Ad hoc Networks) facilitate military communications by forwarding information to respective nodes at the correct time. But secured and robust communication has become the most crucial task in which the information transmitted to two troops fighting in the battery field via the same nodes may be disintegrated and data loss can happen. Several earlier studies have focused on interference-aware routing in a MANET environment. Military environments have mobile nodes while their infrastructure is more or less static, creating issues in interference-aware routings specifically when groups of soldiers disperse in different directions. This research work attempts to cross this hurdle and overcomes this issue with its proposed QoS-IRDMANET (Quality of Services and Interference aware Routing in Dynamic MANETs). Routes defined in this scheme consider QoS criterion along with interference conditions using a weighted sum method. This scheme renders priority in data communications by allocation of more bandwidths to respective communications at executions where critical information is immediately shared with corresponding troops. Moreover, path failures are also taken into account by this scheme owing to the unavailability of resources or node movements. The proposed scheme is demonstrated through simulations with satisfactory results when compared to earlier similar works in this area.
IL33-regulated NPM1 promotes fibroblast-to-myofibroblast transition via ERK/AP-1 signaling in silica-induced pulmonary fibrosis
Authors: Wang Yue , Cheng Demin , Li Ziwei , Sun Wenqing , Zhou Siyun , Peng Lan , Xiong Haojie , Jia Xinying , Li Wei , Han Lei , Liu Yi , Ni Chunhui 
Published: October 2022

Abstract
Background: Silicosis is a global occupational lung disease caused by the accumulation of silica dust. There is a lack of effective clinical drugs, and the pathogenic mechanisms remain obscure. Interleukin 33 (IL33), a pleiotropic cytokine, could promote wound healing and tissue repair via the receptor ST2. However, the mechanisms by which IL33 involves in silicosis progression need further exploration.
Results: Here, we demonstrated that the IL33 levels in the lung sections were significantly overexpressed after bleomycin (BLM) and silica treatment. ChIP assay, knockdown and reverse experiments were performed in lung fibroblasts to prove gene interaction following exogenous IL33 treatment or co-cultured with silica-treated lung epithelial cells. Mechanistically, we illustrated that silica-stimulated lung epithelial cells secreted IL33 and further promoted the activation, proliferation, and migration of pulmonary fibroblasts by activating the ERK/AP-1/NPM1 signaling pathway in vitro. Also, Treatment with NPM1 siRNA-loaded liposomes markedly protected mice from silica-induced pulmonary fibrosis in vivo.
Conclusions: In this study, we identified that NPM1 could involve in the progression of silicosis, which was regulated by IL33/ERK/AP-1 signaling. And treatment methods targeting this pathway may provide new anti-fibrotic clues in pulmonary fibrosis.
Analyzing the Queuing Theory at the Emergency Department at King Hussein Cancer Center
Authors: Qandeel Mahmoud Salameh , Al-Qudah Islam Khaleel , Nayfeh Riyad , Aryan Haitham , Ajaj Omar , Alkhatib Hisham , Hamdan Yousef 
Published: October 2022

Abstract
Objectives: This study was conducted in 2022 at King Hussein Cancer Center (KHCC) to analyze the queuing theory at the Emergency Department (ED) to estimate patients’ wait time, and predict the accuracy of queuing theory.
Methods: According to the statistics, the peak months were July and August, with peak hours from 10 am until 6 pm. The study sample was a week of July 2022, during the peak days and hours. Patients’ wait- time was measured according to three stations: the health informatics desk, triage room, and emergency bed area.
Results: The average number of patients in the line at the health informatics desk was not more than 3, and the waiting time was between 1 and 4 minutes. Since patients were receiving the service immediately in the triage room, there was no waiting time or line because the nurse’s role ends after taking the vital signs and rating the patient’s acuity. Using equations of queuing theory and other relativistic equations in the emergency bed area gave different results. To explain, the queuing theory showed that the average residence time in the system was between 4 and 10 minutes.
Conclusions: Conversely, relativistic equations (ratios of served patients and departed patients and other related variables) demonstrated that the average residence time was between 21 and 36 minutes.
The Neovascular Signal of Myopic Choroidal Neovascularization from Perforating Scleral Vessel Prone to Recur after Anti-VEGF therapy
Authors: She Xiangjun , Yao Wangjing , Liang Zhi , Huang Gongyu , Xie Jin , Tao Jiwei , Wu Sulan , Mao Jianbo , Chen Yiqi , Zhang Yun , Shen Lijun 
Published: October 2022

Abstract
Objectives: To analyzed the recurrence of myopic choroidal neovascularization (mCNV) based on the neovascular signal from perforating scleral vessel (PSV) by optical coherence tomography angiography (OCTA) after anti-vascular endothelial growth factor (anti-VEGF) therapy.
Methods:A consecutive series of naïve patients with mCNV accepted anti-VEGF therapy with a minimum 12-month follow-up period. The location of PSV with CNV were classified into PSV adjacent to CNV or not by B scan and the flow signal of CNV was classified into the neovascular signal of CNV from PSV or not by OCTA. The recurrence of mCNV in various PSV with CNV types were compared. K-M survival and Cox proportional hazard model analysis were used to identify risk factors associated with recurrence of mCNV.
Results: PSVs were found in 59 of 63 eyes (93.7%) with mCNV in the macular region. The eyes with presence of neovascular signal of CNV from PSV were detected 25 eyes (39.7%). The overall mCNV recurrence rate was 46.0% (29/63) during the follow-up period. According to K-M analysis, the presence of neovascularization with mCNV from PSV predicted a higher recurrence of 60% and a shorter recurrent duration (χ2 =4.486, P=0.034). The Cox proportional hazard model demonstrated that the presence of neovascularization with mCNV from PSV was an independent risk factor for recurrence (HR: 2.19, 95%Cl 1.04-4.62).
Conclusions:PSV was mainly detected with mCNV. When the neovascularization of the mCNV comes from PSV, it has a greater recurrence rate with a shorter recurrence duration.
Inhibition of Notch pathway Alleviates nab-Paclitaxel-Induced Peripheral Neuropathic Pain in Rats via Suppressing HMGB1/TLR4 Signaling in Spinal Cord
Authors: Wei Xing , Zhou Yaqing , Ma Li , Li Weimiao , Shan Changyou , Zhang Shuqun , Zhao Yonglin 
Published: October 2022

Abstract
Paclitaxel is widely used in clinical treatment of cancer and peripheral neuropathy is a common adverse side effect of paclitaxel. Diverse mechanisms contribute to the development and maintenance of paclitaxel-induced peripheral neuropathy. However, the role of spinal notch pathway in paclitaxel-induced peripheral neuropathy is not completely understood. In this study, we established an animal model of paclitaxel-induced peripheral neuropathy using nab-paclitaxel. We found that the mechanical and thermal pain threshold of rats was decreased with treatment of nab-paclitaxel, accompanied by increased expression of Notch pathway related proteins, enhanced apoptosis, neuronal and axonal injury, and glial responses. Using DAPT, an inhibitor for notch pathway, could restore the mechanical and thermal threshold and decrease apoptosis, neuronal and axonal injury, and glial responses induced by nab-paclitaxel. DAPT relieved paclitaxel-induced peripheral neuropathy by inhibiting activation of Notch pathway related proteins, then inhibited HMGB1/TLR4 signaling pathway, reduced the expression of inflammatory factor tumor necrosis factor-α and interleukin-1β and accelerated nerve regeneration. Taking together, our study demonstrated that Notch pathway may serve as a potential target for paclitaxel-induced peripheral neuropathy intervention.
Evaluation of Laboratory Values Affecting Mortality of End-stage Renal Disease Patients: A Competing Risks Approach
Authors: Malek Rayka , Baghestani Ahmadreza , Rashid-Farokhi Farin , Shafaghi Shadi , Minoo Farzanehsadat , Eghbali Foolad , Chandra Navin , Shafaghi Masoud , Bonyadi Kaveh , Hosseini-Baharanchi Fatemeh Sadat 
Published: October 2022

Abstract
Background

Chronic Kidney Disease (CKD) is a prevalent and life-threatening situation recognized as an emerging health issue. The present study aimed to evaluate the effect of laboratory parameters on the survival of patients with End-Stage Renal Disease (ESRD) in a hemodialysis (HD) center in Iran.

Materials and methods

This study was conducted on patients receiving chronic HD in Iran Helal Pharmaceutical and Clinical Complex between 2014–2018. The survival time was considered as the time interval between HD initiation and death. Receiving kidney transplantation was regarded as a competing risk, and an improper form of two-parameter Weibull distribution was utilized to simultaneously model the time to both death and renal transplantation. The Bayesian approach was conducted for parameters estimation.

Results

Overall, 29 (26.6%) patients expired, and 19 (17.4%) received kidney transplants. The male gender was related to poor survival, having nearly 4.6 folds higher hazard of mortality (90% HPD region: 1.36–15.49). Moreover, Serum calcium levels ≥9.5 mg/dL (adjusted Sub-hazard ratio (S-HR)=2.33, 90% HPD region: 1.05–5.32) and intact parathyroid hormone (iPTH) ≤150 pg/mL (adjusted S-HR = 2.56, 90% HPD region: 1.09–6.15) were associated with an elevated hazard of mortality. The cumulative incidence function (CIF) for transplantation was greater than death in the first two years of the study. Subsequently, the CIF for death exceeded transplantation in the following two years. The 4-year cumulative incidence of death and kidney transplantation was 63.7% and 36.3%, respectively.

Conclusion

Male gender, hypercalcemia, and hypoparathyroidism were associated with worse outcomes. Correcting these laboratory parameters may improve patients’ survival in the HD population.
On the flow conditions requiring detailed geometric modeling for multiscale evaluation of coastal forests
Authors: Nomura Reika , Takase Shinsuke , Moriguchi Shuji , Terada Kenjiro 
Published: October 2022

Abstract
The multiscale evaluation method is applied to assess the influence of detailed geometric modeling of trees on their macroscopic attenuation effect against tsunami-like flow. Specifically, we conduct a series of numerical flow tests (NFTs), i.e., 3D flow simulations in a local test domain (LTD), under various inflow conditions to evaluate the macroscopic flow characteristics in the LTD accommodating an array of either simple cylinder or detailed tree models that mimic a coastal forest. After the procedure of NFTs in the multiscale evaluation method is briefly summarized and the corresponding governing equations and analysis conditions are presented, we introduce two indices for evaluating the macroscopic flow characteristics within the framework of multiscale modeling. Based on the NFT results, we discuss how the modeling scheme for trees influences the macroscopic flow characteristics in terms of these indices and clarify the microscopic mechanisms that influence the macroscopic attenuation property. Additionally, the NFT results are compared with the experimental results to justify these discussions, and key factors are explored in terms of reproducing real phenomena. In addition, to apply the multiscale evaluation method to assess the disaster mitigation performance of various types of ecosystems in a realistic situation, we discuss under what circumstances and with what level of detail vegetation should be modeled.
Effect of Lactobacillus brevis (MG000874) on Antioxidant Related Genes Expression of liver and kidney in d-galactose Induced Oxidative stress Mice Model”
Authors: Noureen Saleha , Hussain Tanveer , Noureen Aasma , Altyar Ahmed E. 
Published: October 2022

Abstract
Oxidative stress connected with several stress-associated diseases. Potent radical-scavenging activity of Latic acid bacteria had been stated due to its ridiculous antioxidant activity. This work designed to find the defensive effects of Lactobacillus brevisMG000874 against oxidative injuries induce by d-galactose in vivo and as well as to explore the gene expression changes in oxidative stress induce mice. D-galactose (D-gal) induction (300mg/BW) in mice raised the levels of SOD (superoxide dismutase) and CAT (catalase) determined by spectrophotometer. In addition, Lactobacillus brevis MG000874 altered gene expression of oxidative stress marker at the messenger RNA (mRNA) levels was determined by RT-PCR. In the mouse model, L. brevis MG000874 significantly improved the GST, GPX, SOD, CAT and B-actin levels in kidney, and liver of the D-gal-induced mice. Moreover, the histological investigation indicated that Lactobacillus brevis MG000874 effectively relieved kidney and liver damage in mice induced by D-gal. L. brevis MG000874 as a powerful antioxidant mediator endorsed fitness and lessened the risk of stress-linked diseases.
Ecofriendly power generation of bifacial solar photovoltaic module with waste Polyvinyl chloride flex and Acrylonitrile butadiene styrene road side safety sticker as an alternative reflector: Optimization using Box- Behnken design-based Response Surface Methodology
Authors: Thangaraj Hariharasudhan , David Prince Winston , Balachandran Gurukarthik Babu , Murugesan Pravin 
Published: October 2022

Abstract
Bifacial photovoltaics (PV) is gaining rapid attention and their ability to generate more electricity is accelerating their deployment globally. However, literature on optimal bifacial PV is presented for the installation parameters of the system. In this study, we use response surface methodology (RSM) to investigate the flex and roadside reflector wastes as alternate reflectors for bifacial solar PV panels by using a statistical model. Our primary objective in this study is to examine the significant influence of key input factors (front irradiation, rear irradiation, temperature, thickness, and height) on the irradiance factor, total solar reflectance, and power extracted. The results show that the power extraction of the bifacial PV module using the waste flex material is 9%, higher than that of the road side sticker waste. The result indicates that among all other input factors, front irradiation is the most significant parameter.
Relationships between chronic rhinosinusitis without nasal polyps and obstructive sleep apnea in male patients: a cross-sectional study
Authors: Wang Xiaoai , Zhang Qianqian , Cheng Xiangyu , Wu Xiaolin , Xu Huajun , Zhu Huaming , Li Xinyi , Feng Yunhai , Ye Haibo 
Published: October 2022

Abstract
Purpose: Patients with chronic rhinosinusitis (CRS) often have sleep impairments, and this issue is closely related to obstructive sleep apnea (OSA). However, research using objective examinations to evaluate sleep quality in inpatients with CRS is lacking. This study aimed to explore the sleeping characteristics of CRS without nasal polyps (CRSsNP) when comorbid with OSA using polysomnography (PSG).
Methods: For this cross-sectional, single-center study, we recruited 147 adult male inpatients diagnosed with CRSsNP between March 2019 and April 2020. OSA was diagnosed using standard PSG. The patients were classified into two groups according to their apnea–hypopnea index value: CRSsNP with OSA and CRSsNP without OSA. Demographic features and sleep parameters were evaluated and compared between the groups.
Results: Inpatients with CRSsNP had a high risk of OSA (61.2%). The CRSsNP with OSA group had a higher prevalence of obesity, slept for less time, and were more easily aroused during sleep ( P < 0.001, P = 0.002, and P = 0.001, respectively) than the CRSsNP without OSA group. Logistic regression analysis revealed that patients with CRSsNP and comorbid OSA had a higher risk of microarousal, with an odds ratio (OR) of 1.037 (95% confidence interval [CI]: 1.007–1.068). This association remained significant, even after adjusting for age and body mass index (OR: 1.037, 95% CI: 1.002–1.074; P = 0.036).
Conclusions: Patients with CRSsNP had poor sleep quality and a high risk of OSA. An exaggerated sleeping discontinuity exists in patients with CRSsNP.