bluuebunny/crossref_metadata_2025_split huggingface dataset:
Director's network location and corporate environmental investment in the carbon neutrality age
Authors: Wang Liukai , Su Yun , Huang Heshu , Gong Yu , Wang Weiqin 
Published: November 2022

AbstractAlthough carbon neutrality is a global aim, the potential drivers and influence mechanisms of corporate governance communities are unclear. This study examines the impact of director's network location on corporate environmental investment (CEI) and explores potential channels for CEI performance changes. Using a sample of 495 listed firms in China from 2015 to 2019, we construct a director‐based network using contacts of independent company directors. Results indicate that director's network location has positive economic impacts on CEI performance and that financing constraints are an important mechanism of director's networks affecting CEI. Director's networks positively affect corporate performance by improving CEI. Results are robust to endogeneity concerns and contribute to the CEI literature by showing a positive effect between director's network and CEI, as well as between director's network and enterprise value. This paves the way for policymakers, managers, and investors to understand the influence of director's network on CEI performance.
Peptide‐functionalized double network hydrogel with compressible shape memory effect for intervertebral disc regeneration
Authors: Ho Chia‐Yu , Wang Chen‐Chie , Wu Tsung‐Chiao , Kuan Chen‐Hsiang , Liu Yu‐Chung , Wang Tzu‐Wei 
Published: November 2022

AbstractAs a prominent approach to treat intervertebral disc (IVD) degeneration, disc transplantation still falls short to fully reconstruct and restore the function of native IVD. Here, we introduce an IVD scaffold consists of a cellulose‐alginate double network hydrogel‐based annulus fibrosus (AF) and a cellulose hydrogel‐based nucleus pulposus (NP). This scaffold mimics native IVD structure and controls the delivery of Growth Differentiation Factor‐5 (GDF‐5), which induces differentiation of endogenous mesenchymal stem cells (MSCs). In addition, this IVD scaffold has modifications on MSC homing peptide and RGD peptide which facilitate the recruitment of MSCs to injured area and enhances their cell adhesion property. The benefits of this double network hydrogel are high compressibility, shape memory effect, and mechanical strength comparable to native IVD. In vivo animal study demonstrates successful reconstruction of injured IVD including both AF and NP. These findings suggest that this double network hydrogel can serve as a promising approach to IVD regeneration with other potential biomedical applications.
Recent advances in surgical strategies and liver transplantation for hepatoblastoma
Authors: Honda Masaki , Uchida Koushi , Irie Tomoaki , Hirukawa Kazuya , Kadohisa Masashi , Shimata Keita , Isono Kaori , Shimojima Naoki , Sugawara Yasuhiko , Hibi Taizo 
Published: November 2022

AbstractHepatoblastoma (HB) is the most common malignant liver tumor in children. Although the development of treatment strategies with advances in chemotherapy has greatly improved the prognosis of HB, surgical resection and liver transplantation still play a vital role in the treatment of HB. In recent years, technological innovations have led to the development of new surgical approaches for HB. In this review, we describe the latest research on the surgical management of HB, including new imaging technologies, minimally invasive approaches, and the application of associating liver partition portal vein ligation for staged hepatectomy. We also discuss the current role of liver transplantation, use of ante‐situm or ex‐situ liver resection with auto‐transplantation, and management of metastatic HB.
Long‐term outcomes after paclitaxel‐coated balloon angioplasty of femoropopliteal arteries in Asian patients of the IN.PACT Global Study
Authors: Ko Young‐Guk , Choi Donghoon , Rha Seung‐Woon , Won Je Hwan , Do Young‐Soo , Lee Seung‐Whan , Menk Jeremiah S. , Kum Steven 
Published: November 2022

AbstractObjectivesThe long‐term data on the use of drug‐coated balloons (DCBs) for femoropopliteal atherosclerotic lesions in the real‐world setting are limited, even more so for racially and geographically distinct populations. The present analysis reports the 5‐year safety and effectiveness outcomes of a DCB in the Asian subset of the prospective, real‐world IN.PACT Global Study.MethodsThe IN.PACT Global Study was a prospective, multicenter, international, single‐arm study designed to assess the long‐term safety and effectiveness of the IN.PACT Admiral DCB in real‐world participants with femoropopliteal artery disease. The present analysis included 114 Asian participants (138 lesions) treated in South Korea and Singapore. Assessments through 5 years included freedom from clinically driven target lesion revascularization, the safety endpoint (a composite of freedom from device‐ and procedure‐related mortality through 30 days; and freedom from major target limb amputation and clinically driven target vessel revascularization within 60 months after the index procedure) and major adverse events.ResultsIn this prespecified Asian subset, there was a high incidence of diabetes mellitus (54.4%), hypertension (78.1%), coronary artery disease (43.9%), and concomitant below‐the‐knee vascular disease of target leg (39.5%). Mean lesion length was 17.4 ± 12.4 cm; 26.8% were in‐stent restenosis, and more than half of the lesions were totally occluded (51.4%) and calcified (54.3%). The 5‐year Kaplan–Meier estimate of freedom from clinically driven target lesion revascularization was 77.1% (95% confidence interval: 67.0%–84.5%). The safety composite endpoint was 76.0%; the cumulative incidence of all‐cause mortality was 19.9%, and no major target limb amputations were reported through 5 years.ConclusionsThis subset analysis of Asian participants from the IN.PACT Global Study demonstrated consistent results with the previously reported data of the IN.PACT Admiral DCB. The data confirm the durable clinical effectiveness and safety profile of the DCB through 5 years for femoropopliteal atherosclerotic disease in this real‐world population.
Bail out lithotripsy to treat delayed valve‐in‐valve TAVR‐related coronary obstruction
Authors: Bingen Brian O. , Al Amri Ibtihal , Montero‐Cabezas Jose M. , van der Kley Frank 
Published: November 2022

AbstractCoronary access difficulty and stent compression by the juxtaposed aortic valve leaflet hamper percutaneous management of delayed coronary artery obstruction (CAO) after valve‐in‐valve (Edwards Sapien 3 in St. Jude Trifecta) transcatheter aortic valve replacement (TAVR). Here, we present a case of delayed post‐TAVR CAO treated with intravascular lithotripsy and multistenting to overcome stent compression by the adjacent calcified leaflet.
Interdisciplinary diagnosis and treatment planning for Class III malocclusion and determining the appropriate anterior tooth positions for individual patients
Authors: Khan Ambereen , Freer Elissa , Ong Desmond 
Published: November 2022

AbstractPatients presenting with Class III malocclusion often present significant challenges for the orthodontist and restorative clinician. The characteristic anterior crossbite is commonly associated with a maxillo‐mandibular skeletal base discrepancy leading to both functional and esthetic issues. Three potential incisal tooth positions are discussed using clinical examples including implants.
Localized Electric Field‐Induced Efficient Photocatalytic Oxidation over Cu‐Doped WO3 Nanofibers with Strong Dopant/Matrix Interaction
Authors: Chen Lv , Lin Yuan , Zhang Jianhua , Xiong Jinyan , Gui Yunyun , Liu Lijun 
Published: November 2022

AbstractPhotocatalytic oxidation technology can mineralize hazardous volatile organic compounds (VOCs), but the poor photocatalytic oxidation activity limits its practical application. Here we develop Cu‐doped WO3 electrospun nanofibers through a non‐equivalent doping strategy. The Cu dopant prefers substituting five‐coordinated W atoms atop the WO3 matrix, inducing strong dopant/matrix interaction (SDMI) effect and prominent charge rearrangement. A localized electric field (LEF) forms pointing from positively charged WO3 matrix to negatively charged Cu dopant, which triggers efficient photoexcited charge separation. Further, the Cu dopant promoted the production of ⋅OH radicals and thereby enhanced VOCs photodegradation. The 0.7 % Cu‐doped WO3 nanofibers show optimal photocatalytic oxidation performance towards formaldehyde and acetone, 5.5 and 4.8 times higher than pristine WO3 nanofibers, respectively. This work highlights the role of dopant‐induced LEF on the charge carriers separation and might shed light on developing more efficient photocatalysts with non‐equivalent dopants.
Financial literacy, the risk‐as‐feelings hypothesis, and passive income generation
Authors: Habyarimana Jean Baptiste , Kakkar Vikas 
Published: November 2022

AbstractLow household wealth has been associated with the lack of participation in risky financial markets. To improve our understanding of how households decide to participate in financial markets, it is important to investigate how financial literacy heterogeneity among heads influences households' risk attitude and capacity and the propensity to invest in various financial markets. Utilizing the U.S. 2016 survey of consumer finances, this article tests the effect of the head's financial literacy on the household's risk attitude and capacity and also examines whether the household's risk tolerance leads to a greater impact of the head's financial literacy on the likelihood of investing in high‐yielding markets. Our key finding is that the head's financial literacy improves the household's risk tolerance, thereby nudging the household to invest in high‐yielding markets. The article identifies improving the head's financial literacy as an efficacious strategy for increasing household wealth via greater participation in higher‐yielding financial markets.
Structural and Functional Insight into the Mechanism of the Fe−S Cluster‐Dependent Dehydratase from Paralcaligenes ureilyticus
Authors: Bayaraa Tenuun , Lonhienne Thierry , Sutiono Samuel , Melse Okke , Brück Thomas B. , Marcellin Esteban , Bernhardt Paul V. , Boden Mikael , Harmer Jeffrey R. , Sieber Volker , Guddat Luke W. , Schenk Gerhard 
Published: November 2022

AbstractEnzyme‐catalyzed reaction cascades play an increasingly important role for the sustainable manufacture of diverse chemicals from renewable feedstocks. For instance, dehydratases from the ilvD/EDD superfamily have been embedded into a cascade to convert glucose via pyruvate to isobutanol, a platform chemical for the production of aviation fuels and other valuable materials. These dehydratases depend on the presence of both a Fe−S cluster and a divalent metal ion for their function. However, they also represent the rate‐limiting step in the cascade. Here, catalytic parameters and the crystal structure of the dehydratase from Paralcaligenes ureilyticus (PuDHT, both in presence of Mg2+ and Mn2+) were investigated. Rate measurements demonstrate that the presence of stoichiometric concentrations Mn2+ promotes higher activity than Mg2+, but at high concentrations the former inhibits the activity of PuDHT. Molecular dynamics simulations identify the position of a second binding site for the divalent metal ion. Only binding of Mn2+ (not Mg2+) to this site affects the ligand environment of the catalytically essential divalent metal binding site, thus providing insight into an inhibitory mechanism of Mn2+ at higher concentrations. Furthermore, in silico docking identified residues that play a role in determining substrate binding and selectivity. The combined data inform engineering approaches to design an optimal dehydratase for the cascade.
Interplay Between Hydrogen Bonding and Electron Transfer in Mixed Valence Assemblies of Triarylamine Trisamides
Authors: Sallembien Quentin , Aoun Paméla , Blanchard Sébastien , Bouteiller Laurent , Raynal Matthieu 
Published: November 2022

AbstractHydrogen‐bonding interactions are assumed to play a critical role in the long‐range transport of light or charge recently observed in supramolecular assemblies of C3‐symmetrical discotic molecules. Herein, the structure of mixed valence assemblies formed by irradiating triarylamine trisamide (TATA) molecules was determined by multifarious techniques under various conditions with the aim of probing the interplay between the hydrogen bonding network and the rate of electron transport in different states (solution, gel, film). Irradiation was performed under initial states that vary by the degree of association of TATA monomers through hydrogen bonds. Firstly, a significant shift of the N−H and C=O stretching frequencies was observed by FTIR upon irradiation thus revealing an overlooked signature of TATA⋅+ species and interacting mixed valence aggregates. Secondly, gels and films both mostly consist of hydrogen‐bonded TATA polymers but their EPR spectra recorded at 293 K reveal very different behaviors: localized electrons in the gels versus fully delocalized electrons in the films. Hydrogen bonding thus appears as a necessary but not sufficient condition to get fast electron transfer rates and a packing of the TATA monomers particularly suitable for charge transport is assumed to exist in the solid state. Finally, defects in the hydrogen bonding network are detected upon increasing the number of radical species in the mixed valence assemblies present in the film state without impeding the delocalization of the unpaired electrons. A delicate balance between hydrogen bonds and packing is thus necessary to get supramolecular polarons in mixed valence TATA assemblies.
Organometallic Platinum(II) Photosensitisers that Demonstrate Ligand‐Modulated Triplet‐Triplet Annihilation Energy Upconversion Efficiencies
Authors: Fitzgerald Sophie A. , Xiao Xiao , Zhao Jianzhang , Horton Peter N. , Coles Simon J. , Knighton Richard C. , Ward Benjamin D. , Pope Simon J. A. 
Published: November 2022

AbstractA series of 2‐phenylquinoxaline ligands have been synthesised that introduce either CF3or OCF3electron‐withdrawing groups at different positions of the phenyl ring. These ligands were investigated as cyclometalating reagents for platinum(II) to give neutral complexes of the form [Pt(C^N)(acac)] (in which C^N=cyclometalating ligand; acac=acetyl acetonate). X‐ray crystallographic studies on three examples showed that the complexes adopt an approximate square planar geometry. All examples revealed strong Pt−Pt linear contacts of 3.2041(6), 3.2199(3) and 3.2586(2) Å. The highly coloured complexes display efficient visible absorption at 400–500 nm (ϵ ≈5000 M−1 cm−1) and orange red photoluminescent characteristics (λem=603–620 nm;Φem≤37 %), which were subtly tuned by the ligand. Triplet emitting character was confirmed by microsecond luminescence lifetimes and the photogeneration of singlet oxygen with quantum efficiencies up to 57 %. Each complex was investigated as a photosensitiser for triplet–triplet annihilation energy upconversion using 9,10‐diphenylanthracene as the annihilator species: a range of good upconversion efficiencies (ΦUC5.9–14.1 %) were observed and shown to be strongly influenced by the ligand structure in each case.
Caging of a Strongly Pairing Fluorescent Thymidine Analog with Soft Nucleophiles
Authors: Eyberg Juri , Ringenberg Mark , Richert Clemens 
Published: November 2022

AbstractControlling the pairing strength of nucleobases in DNA through reactions with compounds found inside the cell is a formidable challenge. Here we report how a thiazolyl substituent turns a strongly pairing ethynylpyridoneC‐nucleoside into a reactive residue in oligonucleotides. The thiazolyl‐bearing pyridone reacts with soft nucleophiles, such as glutathione, but not with hard nucleophiles like hydroxide or carbonate. The addition products pair much more weakly with adenine in a complementary strand than the starting material, and also change their fluorescence. This makes oligonucleotides containing the new deoxynucleoside interesting for controlled release. Due to its reactivity towardN,P,S, andSe‐nucleophiles, and the visual signal accompanying chemical conversion, the fluorescent nucleotide reported here may also have applications in chemical biology, sensing and diagnostics.
Development and validation of a mathematical model to simulate human cardiovascular and respiratory responses to battlefield trauma
Authors: Jin Xin , Laxminarayan Srinivas , Nagaraja Sridevi , Wallqvist Anders , Reifman Jaques 
Published: November 2022

AbstractMathematical models of human cardiovascular and respiratory systems provide a viable alternative to generate synthetic data to train artificial intelligence (AI) clinical decision‐support systems and assess closed‐loop control technologies, for military medical applications. However, existing models are either complex, standalone systems that lack the interface to other applications or fail to capture the essential features of the physiological responses to the major causes of battlefield trauma (i.e., hemorrhage and airway compromise). To address these limitations, we developed the cardio‐respiratory (CR) model by expanding and integrating two previously published models of the cardiovascular and respiratory systems. We compared the vital signs predicted by the CR model with those from three models, using experimental data from 27 subjects in five studies, involving hemorrhage, fluid resuscitation, and respiratory perturbations. Overall, the CR model yielded relatively small root mean square errors (RMSEs) for mean arterial pressure (MAP; 20.88 mm Hg), end‐tidal CO2 (ETCO2; 3.50 mm Hg), O2 saturation (SpO2; 3.40%), and arterial O2 pressure (PaO2; 10.06 mm Hg), but a relatively large RMSE for heart rate (HR; 70.23 beats/min). In addition, the RMSEs for the CR model were 3% to 10% smaller than the three other models for HR, 11% to 15% for ETCO2, 0% to 33% for SpO2, and 10% to 64% for PaO2, while they were similar for MAP. In conclusion, the CR model balances simplicity and accuracy, while qualitatively and quantitatively capturing human physiological responses to battlefield trauma, supporting its use to train and assess emerging AI and control systems.
Validation of an Announced Telephone Pill Count Compared to a Home‐Visit Pill Count in People With Type 2 Diabetes or Cardiovascular Disease
Authors: Langendoen‐Gort Marlous , Rutters Femke , Huijts Daniëlle , Elders Petra JM , Terwee Caroline B. , Hugtenburg Jacqueline G. 
Published: November 2022

AbstractWe aimed to assess the validity of an announced telephone pill count in people with type 2 diabetes or cardiovascular disease by comparing this method to a home‐visit pill count. We also assessed whether a second telephone pill count improved accuracy. People aged ≥35 years using oral type 2 diabetes or cardiovascular disease medication were included. Thirty‐four participants completed a telephone pill count followed by a home‐visit pill count, and a subsample of this population (n = 11) completed a second telephone pill count. Scatterplots were used for a visual representation of the number of pills counted with both methods, intraclass correlation coefficients for agreement, and Bland‐Altman plots for absolute differences and outliers. A total of 203 pill counts were conducted. The study population consisted of 53% men, with a mean age of 69.6 (±9.2) years and an average of 6.1 (±2.8) medication prescriptions per participant. Scatterplots showed that pills counted with both methods were mostly scattered around they = xequation. Agreement between the first telephone pill count and home‐visit pill count was high, with intraclass correlation coefficients of 0.96 (medication count level) and 0.98 (individual level). No learning effects were observed in the subsample (n = 11), the intraclass correlation coefficient for the first telephone pill count was 0.88 versus 0.89 for the second telephone pill count. Bland‐Altman plots indicated high agreement between the two methods. An announced telephone pill count is considered a valid alternative for a home‐visit pill count in people with type 2 diabetes or cardiovascular disease. A single pill count appears sufficient.
Cluster Amplitudes and Their Interplay with Self‐Consistency in Density Functional Methods
Authors: Jacobson Greta , Marmolejo‐Tejada Juan M. , Mosquera Martín A. 
Published: November 2022

AbstractDensity functional theory (DFT) provides convenient electronic structure methods for the study of molecular systems and materials. Regular Kohn‐Sham DFT calculations rely on unitary transformations to determine the ground‐state electronic density, ground state energy, and related properties. However, for dissociation of molecular systems into open‐shell fragments, due to the self‐interaction error present in a large number of density functional approximations, the self‐consistent procedure based on the this type of transformation gives rise to the well‐known charge delocalization problem. To avoid this issue, we showed previously that the cluster operator of coupled‐cluster theory can be utilized within the context of DFT to solve in an alternative and approximate fashion the ground‐state self‐consistent problem. This work further examines the application of the singles cluster operator to molecular ground state calculations. Two approximations are derived and explored: i) A linearized scheme of the quadratic equation used to determine the cluster amplitudes. ii) The effect of carrying the calculations in a non‐self‐consistent field fashion. These approaches are found to be capable of improving the energy and density of the system and are quite stable in either case. The theoretical framework discussed in this work could be used to describe, with an added flexibility, quantum systems that display challenging features and require expanded theoretical methods.
Engineering Coupled NiSx‐WO2.9 Heterostructure as pH‐Universal Electrocatalyst for Hydrogen Evolution Reaction
Authors: Lin Zheng , Li Kaixun , Tong Yun , Wu Wenbo , Cheng Xiaoxiao , Wang Huijie , Chen Pengzuo , Diao Peng 
Published: November 2022

AbstractExploiting highly active and low‐cost materials as pH‐universal electrocatalysts for the hydrogen evolution reaction (HER) and achieving high‐purity hydrogen fuel is highly desirable but remains challenging. Herein, a novel type of coupled heterostructure was designed by simple electrodeposition followed by a sulfurization treatment. This hierarchical structure was composed of nickel sulfides (NiS, NiS2, denoted as NiSx) and oxygen‐deficient tungsten oxide (WO2.9), which was directly grown on nickel foam (NF) as self‐supporting electrodes (NiSx‐WO2.9/NF) for HER over a wide pH range. The systematic experimental characterizations confirmed that the material had abundant catalytic active sites, fast interfacial electron transfer ability, and strong electronic interaction, resulting in the optimized reaction kinetics for HER. Consequently, the NiSx‐WO2.9/NF catalyst required low overpotentials of 96 and 117 mV to reach current densities of 50 and 100 mA cm−2 in an alkaline medium, outperforming most of the reported non‐noble metal‐based materials. Moreover, this self‐supported electrode exhibited impressive performance over a wide pH range, only requiring 220 and 304 mV overpotential at 100 mA cm−2 in 0.5 m H2SO4 and 1 m phosphate‐buffered saline electrolytes. This work may offer a new approach to the development of advanced pH‐universal electrodes for hydrogen production.