bluuebunny/crossref_metadata_2025_split huggingface dataset:
ANALISIS PERAMALAN TIME SERIES UNTUK PENGELOLAAN PERMINTAAN DENGAN METODE ARIMA BOX-JENKINS (Studi Kasus di CV. TOMY BAKERY)
Authors: Maâ€™Fulloh  , Sumarsono  
Published: February 2022

Fluktuasi permintaan yang tinggi, menjadi masalah untuk perusahaan kecil maupun besar. Hal tersebut juga terjadi pada CV. Tomy Bakery sebagai produsen roti plemben (kering dan basah). Penelitian ini bertujuan untuk melakukan analisis peramalan penjualan roti dengan model ARIMA yang tepat pada roti kering dan basah dan mengimplementasikan hasil peramalan untuk pengelolaan permintaan roti kering dan basah. Metode analisis menggunakan metode time series ARIMA Box Jenkins. Data penelitian berupa data penjualan harian produk roti kering dan basah. Hasil temuan model ARIMA pada roti kering yakni ARIMA (4,0,4), kemudian roti basah yakni ARIMA (5,1,1). Hasil ini menunjukan penjualan roti kering saat waktu t dipengaruhi penjualan saat t-1, t-3, dan t-4 (pola permintaan siklus 4 harian). Kemudian penjualan roti basah saat t dipengaruhi penjualan saat t-1, t-2, t-3, t-4, t-5 dan t-6 (pola permintaan siklus 6 harian). Implementasi dari hasil peramalan penjualan diketahui adanya pengaruh waktu harian. Maka keputusan hari promosi yang tepat dengan harga diskon, menjadi penting untuk mengelola permintaan. Sebagai saran hari promosi untuk roti kering yakni saat hari t-2 (selasa) dan t-3 (rabu) dan atau hari t-6 (sabtu) dan t-7 (minggu). Kemudian untuk roti basah yakni saat t-4 (kamis) dan t-5 (jumat). Penerapan promosi pada hari diatas, akan bisa meratakan permintaan di sepanjang minggu. Dampaknya bisa mengurangi biaya simpan inventory pada saat peak day, juga membuat level produk dari hari ke hari akan relative sama (tidak berfluktuasi).
High-Efficiency Flexible Organic Photovoltaics and Thermoelectricities Based on Thionyl Chloride Treated PEDOT:PSS Electrodes
Authors: Wan Juanyong , Fan Xi , Li Yunfei , Li Pengcheng , Zhang Ting , Hui Kwun Nam , Huang Huihui , Kang Kai , Qian Lei 
Published: March 2022

Conducting polymers have received tremendous attentions owing to their great potentials to harvest both luminous and thermal energies. Here, we reported a flexible transparent electrode of poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate) (PEDOT:PSS) with highly electrical conductivity and raised Seebeck coefficient via thionyl chloride treatments. The comprehensive studies of optical, electrical, morphological, structural, and thermoelectrical properties, work function, and stability of the PEDOT:PSS transparent electrodes were systematically evaluated and described. On the basis of the PEDOT:PSS transparent electrodes, the resultant flexible organic solar cells yielded a high power conversion efficiency of 15.12%; meanwhile, the flexible thermoelectricities exhibited the raised power factor of 115.9 μW m−1 K−2, which outperformed the four kinds of rigid thermoelectricities with conventional acid and base treatments.
Machine Learning for Electrocardiographic Features to Identify Left Atrial Enlargement in Young Adults: CHIEF Heart Study
Authors: Hsu Chu-Yu , Liu Pang-Yen , Liu Shu-Hsin , Kwon Younghoon , Lavie Carl J. , Lin Gen-Min 
Published: March 2022

BackgroundLeft atrial enlargement (LAE) is associated with cardiovascular events. Machine learning for ECG parameters to predict LAE has been performed in middle- and old-aged individuals but has not been performed in young adults.MethodsIn a sample of 2,206 male adults aged 17–43 years, three machine learning classifiers, multilayer perceptron (MLP), logistic regression (LR), and support vector machine (SVM) for 26 ECG features with or without 6 biological features (age, body height, body weight, waist circumference, and systolic and diastolic blood pressure) were compared with the P wave duration of lead II, the traditional ECG criterion for LAE. The definition of LAE is based on an echocardiographic left atrial dimension &gt; 4 cm in the parasternal long axis window.ResultsThe greatest area under the receiver operating characteristic curve is present in machine learning of the SVM for ECG only (77.87%) and of the MLP for all biological and ECG features (81.01%), both of which are superior to the P wave duration (62.19%). If the sensitivity is fixed to 70–75%, the specificity of the SVM for ECG only is up to 72.4%, and that of the MLP for all biological and ECG features is increased to 81.1%, both of which are higher than 48.8% by the P wave duration.ConclusionsThis study suggests that machine learning is a reliable method for ECG and biological features to predict LAE in young adults. The proposed MLP, LR, and SVM methods provide early detection of LAE in young adults and are helpful to take preventive action on cardiovascular diseases.
Mining-Induced Stress and Ground Pressure Behavior Characteristics in Mining a Thick Coal Seam With Hard Roofs
Authors: Zhu Zhijie , Wu Yunlong , Liang Zhuang 
Published: March 2022

The hard roof of coal mines has the characteristics of high hardness, good integrity, and large layer thickness, which leads to many ground control problems. To reveal the influence of a hard roof structure on the stress performance and coal pillar stability during mining operations, the 8,104 and 8,105 working faces in the Tongxin coal mine were considered as the research object to analyze the stress behavior during the working face advance. Numerical simulation software FLAC3D was used to establish the numerical model of the longwall face under hard roof conditions. The stress distribution laws and coal pillar stability under different roof strengths were analyzed so as to explain the impacts of the hard roof on the stress distribution at the working face. The results show that during the second face proceeding, the influence zone of the front abutment pressure under hard roof conditions is 6 m wider than that under soft roof conditions, and the bearing stress at the working face is 10.4 MPa higher. At the mining position, the plastic zone of the pillar under hard roof conditions is 11 m wider than that under soft roof conditions, and the peak vertical stress is 5.13 MPa higher than that under soft roof conditions. At 25 m ahead of the working face, the plastic zone of the pillar under hard roof conditions is 6 m wider than that under soft roof conditions, and the peak vertical stress is 24.84 MPa higher than that under soft roof conditions. Additional overburden pressure produced by the uncaved hard roof increased pillar stress and plastic zones. Therefore, the hard roof is the main cause of strong ground pressure behavior in the Tongxin coal mine. Aiming at the strong mine pressure behavior, it is suggested to adopt the pre-splitting technology to reduce the influence of the hard roof on mine pressure.
Treatment Adherence to Injectable Treatments in Pediatric Growth Hormone Deficiency Compared With Injectable Treatments in Other Chronic Pediatric Conditions: A Systematic Literature Review
Authors: Gomez Roy , Ahmed S. Faisal , Maghnie Mohamad , Li Dejun , Tanaka Toshiaki , Miller Bradley S. 
Published: March 2022

BackgroundPediatric patients with growth hormone deficiency (GHD) are currently treated with daily injections of recombinant human growth hormone (rhGH) to promote linear growth and enable attainment of normal adult height. One of the main reasons for suboptimal growth during rhGH therapy is non-adherence to treatment. The objective of this systematic literature review was to examine the recent literature on pediatric adherence to injectable treatments for chronic conditions (focusing on rhGH) to characterize levels of adherence and identify the factors/barriers associated with adherence.MethodsThe Embase and MEDLINE databases (January 2015–October 2020) were searched to identify publications describing studies of pediatric patients (aged ≤17 years) with GHD and other chronic conditions requiring daily or weekly injectable treatments; a similar targeted search of Chinese literature was also performed. Adherence data were extracted from the included studies and summarized. Risk of bias was determined using the Cochrane Risk of Bias tool 2 or the Newcastle-Ottawa Scale.ResultsA total of 23 publications were included, with all publications except for one (multiple sclerosis) focused on pediatric GHD studies: there were two clinical trials, 18 observational studies and three survey studies. Study sample sizes ranged from 30 to 13,553 patients (median: 95 patients). The definition of adherence varied between studies and included mean adherence rate, median adherence rate, and the percentage of patients within pre-specified adherence categories. Of the publications assessing adherence to daily rhGH, 11 studies reported 12-month mean adherence rate (range: 73.3%– 95.3%) and eight studies reported median adherence (range: 91%– 99.2%). The barriers to treatment adherence identified included self-administration, increased administration frequency, age (adolescence), longer treatment duration, device design, and insufficient family education, awareness, and/or engagement. Recommendations for increasing adherence included using adherence reminder tools, increasing patient engagement/education, and improving injection device design and drug product.ConclusionsAdherence to rhGH treatment was high (&gt;80%) for many studies, though comparability between studies was limited given the substantial heterogeneity in the way adherence was defined, measured, and reported. To address this heterogeneity, we recommend standardizing how adherence is defined and reported and encourage the use of standardized study designs and outcome measures.
Genome-Wide Association Studies Provide Insight Into the Genetic Determination for Hyperpigmentation of the Visceral Peritoneum in Broilers
Authors: Zhou Guangyuan , Liu Tianfei , Wang Yan , Qu Hao , Shu Dingming , Jia Xinzheng , Luo Chenglong 
Published: March 2022

Hyperpigmentation of the visceral peritoneum (HVP) has been becoming one of the most challenging problems in yellow-feathered chicken production, which seriously affected chicken carcass quality traits. Detecting which genes dominantly impact pigmentation in the peritoneum tissues is of great benefit to the genetic improvement of HVP. To investigate the genetic mechanism of HVP in yellow-feathered broilers, genome-wide association studies (GWASs) were conducted in the F2 generation of a cross broiler population with 395 birds. A total of 115,706 single-nucleotide polymorphisms (SNPs) of 122,415 were retained to identify quantitative trait loci (QTL) associated to HVP in chicken. The GWAS results based on the logistic mixed model (LMM) revealed that a narrow genomic location on chromosomes 1 (49.2–51.3 Mb) was significantly associated (p ≤ 4.32 × 10−7) with HVP, which contained 23 SNP makers related to 14 functional genes (MFNG, POLDIP3, POLR2F, PICK1, PDXP, SGSM3, RANGAP1, MYH9, RPL3, GALP3, LGALS1, MICALL1, ATF4, and CYP2D6). Four highly associated (p &lt; 10−5) haplotype blocks of 0.80 kb (two SNPs), 0.06 kb (two SNPs), 0.95 kb (two SNPs), and 0.03 kb (two SNPs) were identified with two, two, four, and four distinct haplotypes, respectively. As a melanoma-associated gene, CYP2D6 were also possibly involved in the development of HVP occurring in chicken with two significant variations (rs314284996 and rs317955795) in the promoter regions. Further tests revealed that the expression of CYP2D6 was obviously higher in the visceral peritoneum tissue of chicken with HVP than that in the normal group (p &lt; 0.05). Our results provide a novel clue to understand the genetic mechanism of HVP generation in chicken, and the mapped QTL or candidate genes might serve for genomic selection to improve carcass quality in the yellow-feathered chicken industry.
Validation of New Gene Variant Classification Methods: a Field-Test in Diagnostic Cardiogenetics
Authors: Alimohamed Mohamed Z. , Westers Helga , Vos Yvonne J. , Van der Velde K. Joeri , Sijmons Rolf H. , Van der Zwaag Paul A. , Sikkema-Raddatz Birgit , Jongbloed Jan D. H. 
Published: March 2022

Background: In the molecular genetic diagnostics of Mendelian disorders, solutions are needed for the major challenge of dealing with the large number of variants of uncertain significance (VUSs) identified using next-generation sequencing (NGS). Recently, promising approaches using constraint metrics to calculate case excess scores (CE), etiological fractions (EF), and gnomAD-derived constraint scores have been reported that estimate the likelihood of rare variants in specific genes or regions that are pathogenic. Our objective is to study the usability of these constraint data into variant interpretation in a diagnostic setting, using our cardiomyopathy cohort.Methods and Results: Patients (N = 2002) referred for clinical genetic diagnostics underwent NGS testing of 55–61 genes associated with cardiomyopathies. Previously classified likely pathogenic (LP) and pathogenic (P) variants were used to validate the use of data from CE, EF, and gnomAD constraint analyses for (re)classification of associated variant types in specific cardiomyopathy subtype-related genes. The classifications corroborated in 94% (354/378) of cases. Next, we reclassified 23 unique VUSs to LP, increasing the diagnostic yield by 1.2%. In addition, 106 unique VUSs (5.3% of patients) were prioritized for co-segregation or functional analyses.Conclusions: Our analysis confirms that the use of constraint metrics data can improve variant interpretation, and we, therefore, recommend using constraint scores on other cohorts and disorders and its inclusion in variant interpretation protocols.
ALKBH5-Mediated m6A Modification of A20 Regulates Microglia Polarization in Diabetic Retinopathy
Authors: Chen Tingting , Zhu Wenhui , Wang Congyao , Dong Xia , Yu Fenfen , Su Yihua , Huang Jingwen , Huo Lijun , Wan Pengxia 
Published: March 2022

BackgroundTo investigate the role of microglia polarization in the pathogenesis of diabetic retinopathy, and study the mechanism of ALKBH5-mediated m6A modification of A20 of retinal microglia polarization.MethodsDiabetics rats were constructed and the M1/M2 polarization of retinal microglia was determined using immunofluorescence, flow cytometry, and quantitative real-time PCR (qRT-PCR). Glucose at different concentrations was added to treat the microglia, and the polarization rate was detected. RNA sequencing was performed to identify the differentially expressed gene in glucose treated microglia, and A20 expression was confirmed by qRT-PCR and western blotting. Lentiviruses encoding shRNA for A20 or overexpressing A20 were constructed to clarify the role of A20 in microglia polarization in vitro and vivo. N6-methyladenosine (m6A) modification level and degradation rate of A20 were determined and m6A related proteins were detected.ResultsDiabetics rats showed a higher M1 polarization rate but lower M2 polarization rate of retinal microglia. With the increase of glucose concentration, microglia tend to polarize into M1 inflammatory type rather than M2 anti-inflammatory type. Shown by RNA sequencing, glucose treated microglia showed a differentially expressed gene profile, which was enriched in kinds of inflammatory categories and pathways. A20 expression was lower in microglia with glucose treatment, which was demonstrated to negatively regulate the M1 polarization. Moreover, intraocular injection of A20-overexpression lentiviruses (OE-A20) rectified the enhanced M1 retinal microglia polarization of diabetes rats. The higher m6A modification level and faster degradation rate of A20 was observed in glucose treated microglia, which was mediated by m6A demethylase ALKBH5.ConclusionLower expression A20 resulted in the enhanced M1 polarization of retinal microglia in diabetic retinopathy, which was caused by ALKBH5 mediated m6A modification. This study may provide new perspectives on not only the pathogenesis but also the diagnosis and treatment for diabetic retinopathy.
Transarterial Chemoembolization Combined With Lenvatinib Plus PD-1 Inhibitor for Advanced Hepatocellular Carcinoma: A Retrospective Cohort Study
Authors: Cai Mingyue , Huang Wensou , Huang Jingjun , Shi Wenbo , Guo Yongjian , Liang Licong , Zhou Jingwen , Lin Liteng , Cao Bihui , Chen Ye , Zhou Juan , Zhu Kangshun 
Published: March 2022

PurposeTo investigate the efficacy and safety of transarterial chemoembolization (TACE) combined with lenvatinib plus PD-1 inhibitor (TACE-L-P) versus TACE combined with lenvatinib (TACE-L) for patients with advanced hepatocellular carcinoma (HCC).Materials and MethodsData of advanced HCC patients treated with TACE-L-P (TACE-L-P group) or TACE-L (TACE-L group) from January 2019 to December 2020 were prospectively collected and retrospectively analyzed. The differences in overall survival (OS), progression-free survival (PFS), tumor responses (based on modified Response Evaluation Criteria in Solid Tumors) and adverse events (AEs) were compared between the two groups. Potential factors affecting OS and PFS were determined.ResultsA total of 81 patients were included in this study. Among them, 41 received TACE-L-P and 40 received TACE-L. The patients in TACE-L-P group had prolonged OS (median, 16.9 vs. 12.1 months, P=0.009), longer PFS (median, 7.3 vs. 4.0 months, P=0.002) and higher objective response rate (56.1% vs. 32.5%, P=0.033) and disease control rate (85.4% vs. 62.5%, P=0.019) than those in TACE-L group. Multivariate analyses revealed that the treatment option of TACE-L, main portal vein invasion and extrahepatic metastasis were the independent risk factors for OS, while TACE-L and extrahepatic metastasis were the independent risk factors for PFS. In subgroup analyses, a superior survival benefit was achieved with TACE-L-P in patients with extrahepatic metastasis or tumor number &gt;3 but not in those with main portal vein invasion. The incidence and severity of AEs in TACE-L-P group were comparable to those in TACE-L group (any grade, 92.7% vs. 95.0%, P=1.000; grade 3, 36.6% vs. 32.5%, P=0.699).ConclusionTACE-L-P significantly improved survival over TACE-L with an acceptable safety profile in advanced HCC patients, especially those with extrahepatic metastasis or tumor number &gt;3 but without main portal vein invasion.
Mild Cognitive Impairment Subtypes Are Associated With Peculiar Gait Patterns in Parkinson’s Disease
Authors: Amboni Marianna , Ricciardi Carlo , Cuoco Sofia , Donisi Leandro , Volzone Antonio , Ricciardelli Gianluca , Pellecchia Maria Teresa , Santangelo Gabriella , Cesarelli Mario , Barone Paolo 
Published: March 2022

BackgroundMild cognitive impairment (MCI) is frequent in Parkinson’s disease (PD) and represents a risk factor for the development of dementia associated with PD (PDD). Since PDD has been associated with disability, caregiver burden, and an increase in health-related costs, early detection of MCI associated with PD (PD-MCI) and its biomarkers is crucial.ObjectiveGiven that gait is considered a surrogate marker for cognitive decline in PD, the aim of this study was to compare gait patterns in PD-MCI subtypes in order to verify the existence of an association between specific gait features and particular MCI subtypes.MethodsA total of 67 patients with PD were consecutively enrolled and assessed by an extensive clinical and cognitive examination. Based on the neuropsychological examination, patients were diagnosed as patients with MCI (PD-MCI) and without MCI (no-PD-MCI) and categorized in MCI subtypes. All patients were evaluated using a motion capture system of a BTS Bioengineering equipped with six IR digital cameras. Gait of the patients was assessed in the ON-state under three different tasks (a single task and two dual tasks). Statistical analysis included the t-test, the Kruskal–Wallis test with post hoc analysis, and the exploratory correlation analysis.ResultsGait pattern was poorer in PD-MCI vs. no-PD-MCI in all tasks. Among PD-MCI subtypes, multiple-domain PD-MCI and amnestic PD-MCI were coupled with worse gait patterns, notably in the dual task.ConclusionBoth the magnitude of cognitive impairment and the presence of memory dysfunction are associated with increased measures of dynamic unbalance, especially in dual-task conditions, likely mirroring the progressive involvement of posterior cortical networks.
Modulation of TLR/NF-κB/NLRP Signaling by Bioactive Phytocompounds: A Promising Strategy to Augment Cancer Chemotherapy and Immunotherapy
Authors: Fakhri Sajad , Moradi Seyed Zachariah , Yarmohammadi Akram , Narimani Fatemeh , Wallace Carly E. , Bishayee Anupam 
Published: March 2022

BackgroundTumors often progress to a more aggressive phenotype to resist drugs. Multiple dysregulated pathways are behind this tumor behavior which is known as cancer chemoresistance. Thus, there is an emerging need to discover pivotal signaling pathways involved in the resistance to chemotherapeutic agents and cancer immunotherapy. Reports indicate the critical role of the toll-like receptor (TLR)/nuclear factor-κB (NF-κB)/Nod-like receptor pyrin domain-containing (NLRP) pathway in cancer initiation, progression, and development. Therefore, targeting TLR/NF-κB/NLRP signaling is a promising strategy to augment cancer chemotherapy and immunotherapy and to combat chemoresistance. Considering the potential of phytochemicals in the regulation of multiple dysregulated pathways during cancer initiation, promotion, and progression, such compounds could be suitable candidates against cancer chemoresistance.ObjectivesThis is the first comprehensive and systematic review regarding the role of phytochemicals in the mitigation of chemoresistance by regulating the TLR/NF-κB/NLRP signaling pathway in chemotherapy and immunotherapy.MethodsA comprehensive and systematic review was designed based on Web of Science, PubMed, Scopus, and Cochrane electronic databases. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines were followed to include papers on TLR/NF-κB/NLRP and chemotherapy/immunotherapy/chemoresistance by phytochemicals.ResultsPhytochemicals are promising multi-targeting candidates against the TLR/NF-κB/NLRP signaling pathway and interconnected mediators. Employing phenolic compounds, alkaloids, terpenoids, and sulfur compounds could be a promising strategy for managing cancer chemoresistance through the modulation of the TLR/NF-κB/NLRP signaling pathway. Novel delivery systems of phytochemicals in cancer chemotherapy/immunotherapy are also highlighted.ConclusionTargeting TLR/NF-κB/NLRP signaling with bioactive phytocompounds reverses chemoresistance and improves the outcome for chemotherapy and immunotherapy in both preclinical and clinical stages.