bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of symptomatology and viral load among residents and healthcare staff in long-term care facilities: A coronavirus disease 2019 retrospective case-cohort study
Authors: van Hensbergen Mitch , den Heijer Casper D. J. , Mujakovic Suhreta , Dukers-Muijrers Nicole H. T. M. , Wolffs Petra F. G. , van Loo Inge H. M. , Hoebe Christian J. P. A. 
Published: November 2022

Objectives
We evaluated COVID-19 symptoms, case fatality rate (CFR), and viral load among all Long-Term Care Facility (LTCF) residents and staff in South Limburg, the Netherlands (February 2020-June 2020, wildtype SARS-CoV-2 Wuhan strain).

Methods
Patient information was gathered via regular channels used to notify the public health services. Ct-values were obtained from the Maastricht University Medical Centre laboratory. Logistic regression analyses were performed to assess associations between COVID-19, symptoms, CFR, and viral load.

Results
Of 1,457 staff and 1,540 residents, 35.1% and 45.2% tested positive for COVID-19. Symptoms associated with COVID-19 for female staff were fever, cough, muscle ache and loss of taste and smell. Associated symptoms for men were cough, and loss of taste and smell. Associated symptoms for residents were subfebrility, fatigue, and fever for male residents only. LTCF residents had a higher mean viral load compared to staff. Male residents had a higher CFR (35.8%) compared to women (22.5%). Female residents with Ct-values 31 or less had increased odds of mortality.

Conclusions
Subfebrility and fatigue seem to be associated with COVID-19 in LTCF residents. Therefore, physicians should also consider testing residents who (only) show aspecific symptoms whenever available resources prohibit testing of all residents. Viral load was higher in residents compared to staff, and higher in male residents compared to female residents. All COVID-19 positive male residents, as well as female residents with a medium to high viral load (Ct-values 31 or lower) should be monitored closely, as these groups have an overall increased risk of mortality.
EXTRACTIVE SUBSTANCES OF SAPROTROPHIC MUSHROOMS: FLAMMULINA VELUTIPES, HYPHOLOMA CAPNOIDES, ARMILLARIA BOREALIS, ARMILLARIA CEPISTIPES. HEAVY METAL CONTENT
Authors: Bakanov Vyacheslav Vadimovich , Vedernikov Dmitriy Nikolaevich , Kruchina-Bogdanov Igor Vadimovich , Eltsova Liubov Sergeevna 
Published: November 2022

The article is concerned to the study and comparison of the extractive substances chemical composition of typical saprotrophic mushrooms that grow in the forests of St. Petersburg and the Leningrad region: Flammulina velutipes, Hypholoma capnoides, Armillaria borealis, Armillaria cepistipes. The article analyzed and compared the chemical composition of low-molecular compounds of caps and legs separately. The composition of heavy metals was compared: cadmium, mercury, iron. The content of heavy metals in the studied fungi was compared with those studied earlier (Lentinula edodes and Pholiota squarrosa). Cadmium and mercury are found mainly in the caps of autumn mushrooms.
The composition of fatty acids, sterols, carbohydrates and sugar alcohols in various parts of mushrooms (stems and caps) was determined and compared. It was revealed that glycerin is presented in all types of mushrooms and is contained in large quantities in the stems and caps of F. velutipes. The qualitative composition of sugar alcohols is approximately the same in all mushrooms, but the quantitative composition has specific differences. Sugar alcohol threitol is contained in Armillaria.
DYNAMICS OF DESTRUCTION OF THE MAIN COMPONENTS OF THE LIGNOCELLULOSE COMPLEX OF AS-PEN WOOD SAWDUST, WHEAT STRAW, AND SUNFLOWER CASING UNDER THE ACTION OF FUNGUS MY-CELIUM PLEUROTUS OSTREATUS
Authors: Pleshkova Ol'ga Gennad'yevna , Teplyakova Tamara Vladimirovna , Shcherbakov Dmitriy Nikolayevich , Kolosov Petr Vladimirovich , Bazarnova Natal'ya Grigor'yevna 
Published: November 2022

The aim of the study was to study the effect of basidiomycetes on the aromatic and carbohydrate components of plant materials under the influence of the mycelium of the Pleurotus ostreatus fungus. To achieve this goal, we carried out a component analysis of the initial plant raw materials and raw materials after exposure to the mycelium of the basidiomycete.
The moisture content in the raw material was determined, and the analysis of the content of: lignin, cellulose, easily and difficultly hydrolysable polysaccharides was carried out. The quantitative analysis of the structural components of plant raw materials was carried out according to the methods generally accepted in the chemistry of plant raw materials, in terms of absolutely dry raw materials.
Chemical analysis of substrates showed that polysaccharides undergo bioconversion in the first place; difficultly hydrolyzable polysaccharides underwent biodegradation to a greater extent. It can be concluded that lignin does not completely destroy lignin on annual plants, as a result of which the growth and productivity of mushrooms increases.
A escola em tempos de pandemia sob o olhar de professores em formação inicial: vivências e desafios
Authors: Lopes Rodrigo Oliveira , Mesquita Priscylla Jordania Pereira de , Lüdke Everton 
Published: November 2022

Este artigo reflete sobre a escola em tempos de pandemia sob a óptica de professores em formação inicial, com base nas vivências destes sujeitos durante o Estágio Curricular Supervisionado em um Curso de Química Licenciatura. Adotando como problema de pesquisa: quais as vivências e percepções de professores em formação inicial sobre a escola em tempos de Ensino Remoto Emergencial (ERE)? Foram analisados os relatórios de 11 estagiários por meio da Análise Textual Discursiva de Moraes e Galiazzi (2016), resultando em cinco categorias: a inserção do estagiário na escola, dificuldades dos estudantes sobre tecnologia, dificuldades de aprendizagem, questões emocionais docentes e desafios da prática docente. Foi possível reconhecer problemas de articulação entre as diferentes instâncias que regulam as atividades escolares e que os estudantes e suas famílias por vezes têm compreensões equivocadas sobre o ERE. Indicando a necessidade de reflexões sobre o atual momento envolvendo todos os agentes do ambiente escolar.
Formação contínua de professores e as (des)articulações com a escola de educação básica
Authors: Costa Elisangela André da Silva , Silva Maria do Socorro Lopes da , Costa Eisenhower Souza 
Published: November 2022

O presente estudo toma como objetivo de investigação a formação contínua de professores. Parte da problematização do atual contexto, em que a docência e os processos formativos são cada vez mais atravessados por princípios neoliberais, que imprimem nas políticas educacionais a lógica da produtividade, performatividade e competitividade. Metodologicamente pautada na abordagem qualitativa, a investigação utilizou como estratégia de aproximação coma realidade uma entrevista narrativa, realizada junto a um professor que atua em turmas de ensino fundamental e médio no município de Horizonte-Ceará. Foi estabelecido como objetivo geral refletir sobre as articulações que se estabelecem entre a formação contínua e os desafios vividos pelos professores no exercício de sua profissão no contexto da educação básica. Os resultados apontaram que mesmo atravessada pelas tensões e contradições presentes na sociedade contemporânea, a formação contínua pode se estabelecer como espaço de diálogo e de valorização da docência e da escola pública.
Educação e Tecnologia: perspectivas para diálogos em torno da educação para a emancipação
Authors: Almeida Antônio Charles Santiago de , Basniak Maria Ivete , Vidal Rafael Gemin 
Published: November 2022

Este ensaio teórico, alicerçado em Adorno (2010), Bourdieu (2014) e Vieira Pinto (2005), admite que educação, política e tecnologia possuem uma relação quase simbiótica. A partir desses três autores, é apresentada uma discussão teórica sobre como as tecnologias, neste contexto, podem contribuir para a emancipação política de indivíduos que, quase sempre, não dispõem de uma herança de cultura. Bourdieu (2014) apresenta-nos os impedimentos de assegurar uma educação que seja justa para todos, pois, para ele, a escola é o lugar da desigualdade social. Por outro lado, Adorno (2010) discute que é preciso formar para a emancipação política, ou seja, para evitar o barbarismo cotidiano. A partir desse contexto de reprodução das estruturas dominantes, bem como de formar indivíduos participantes críticos, e de acordo com Vieira Pinto (2005), defendemos a tese de que a apropriação da tecnologia pode configurar-se como instrumento de superação das desigualdades sociais e do encurtamento das distâncias entre os capitais de cultura.
Parental Involvement in Children’s Initial Literacy Learning in Primary Schools in Mungwi District, Zambia
Authors: Kasakula Maureen 
Published: November 2022

Abstract
This study sought to establish what primary schools were doing to ensure that there was parental involvement in children’s literacy learning. A qualitative design methodology was utilized, and data was collected through interviews, document analysis, and focus group discussions. The study found that parental involvement in children’s initial literacy learning in many schools was only achieved through the strategies put in place by some cooperating partners working with the schools such as Read to Succeed, a nongovernmental organization supported by the United States Agency for International Development (USAID). The strategies put in place by these partners enabled teachers and parents to work together so that parents were able to actively get involved in their children’s initial literacy learning. The study recommends that teacher education seriously consider including components on parental involvement in the college literacy syllabus to enhance teachers’ involvement of parents in children’s initial literacy learning in primary schools. The study further recommends that parental involvement in children’s literacy learning should be embedded in the school curriculum to enhance the commitment of teachers and school administrators.

Key Words: parental involvement, initial literacy, learning, primary schools, children
DETERMINAN MANAJEMEN PAJAK PERUSAHAAN: UKURAN PERUSAHAAN, PENDANAAN UTANG, PROFITABILITAS, INTENSITAS ASET TETAP DAN MEKANISME TATA KELOLA
Authors: Pratiwi Umi 
Published: November 2022

This study aims to examine financial (firm size, leverage, profitability, capital intensity) and non-financial factors (independent commissioners, audit committees, managerial ownership, institutional ownership as corporate governance mechanisms) on corporate tax management in manufacturing firms listed on the Indonesian Stock Exchange 2016-2017. The population of this research is 151 manufacturing firms. The sample measurement method is purposive sampling to obtain 36 sample firms with 72 observations according to the observation period. Data is analyzed with multiple regression analysis methods. The results of this research indicate that profitability, capital intensity, independent commissioners and audit committees influence the corporate tax management partially. Meanwhile, firm size, leverage, managerial and institutional ownership have no influence on tax management. In general, corporate tax management can be indicated from the financial and non-financial factors.
24/7 workflow for bloodstream infection diagnostics in microbiology laboratories: the first step to improve clinical management
Authors: Chirio David , Demonchy Elisa , Le Marechal Marion , Gaudart Alice , Lotte Romain , Carles Michel , Ruimy Raymond 
Published: November 2022

Abstract

Objectives
We aimed to evaluate the impact of an uninterrupted workflow regarding blood cultures on turnaround time and antibiotic prescription.

Methods
Monomicrobial episodes of bacteremia were retrospectively evaluated before and after a continuous 24/7 workflow was implemented in our clinical microbiology laboratory (pre- and post-intervention periods; PREIP and POSTIP). Primary outcome was the time from specimen collection to the first change in antibiotic therapy. Secondary outcomes included the time from specimen collection to effective antibiotic therapy and to antibiotic susceptibility testing results (or turnaround time), as well as hospital length of stay and all-cause mortality at 30 days.

Results
A total of 548 episodes of bacteremia were included in the final analysis. There was no difference in PREIP and POSTIP regarding patient characteristics and causative bacteria. In POSTIP, the mean time to the first change in antibiotic therapy was reduced by 10.4 h (p<0.001). The time to effective antibiotic therapy and the turnaround time were respectively reduced by 4.8 h (p<0.001) and 5.1 h (p=0.006) in POSTIP. There was no difference in mean hospital length of stay or mortality between the two groups.

Conclusions
Around the clock processing of blood cultures allows for a reduction in turnaround time, which in turn reduces the delay until effective antibiotic therapy prescription.
Preanalytical stability of SARS-CoV-2 anti-nucleocapsid antibodies
Authors: Niedrist Tobias , Kriegl Lisa , Zurl Christoph J. , Schmidt Felix , Perkmann-Nagele Nicole , Mucher Patrick , Repl Manuela , Flieder Ines , Radakovics Astrid , Sieghart Daniela , Radner Helga , Aletaha Daniel , Binder Christoph J. , Gülly Christian , Krause Robert , Herrmann Markus , Wagner Oswald F. , Perkmann Thomas , Haslacher Helmuth 
Published: November 2022

Abstract

Objectives
Anti-nucleocapsid (NC) antibodies are produced in response to SARS-CoV-2 infection. Therefore, they are well suited for the detection of a previous infection. Especially in the case of seroprevalence studies or during the evaluation of a novel in-vitro diagnostic test, samples have been stored at <−70 °C (short- and long-term) or 2–10 °C (short-term) before analysis. This study aimed to assess the impact of different storage conditions relevant to routine biobanking on anti-NC antibodies.

Methods
The preanalytical impact of short-term storage (84 [58–98] days) on <−70 °C and for 14 days at 2–10 °C was evaluated using samples from 111 donors of the MedUni Vienna Biobank. Long-term effects (443 [409–468] days) were assessed using 208 samples from Biobank Graz and 49 samples from Biobank Vienna. Anti-Nucleocapsid antibodies were measured employing electrochemiluminescence assays (Roche Anti-SARS-CoV-2).

Results
After short-term storage, the observed changes did not exceed the extent that could be explained by analytical variability. In contrast, results after long-term storage were approximately 20% higher and seemed to increase with storage duration. This effect was independent of the biobank from which the samples were obtained. Accordingly, the sensitivity increased from 92.6 to 95.3% (p=0.008). However, comparisons with data from Anti-Spike protein assays, where these deviations were not apparent, suggest that this deviation could also be explained by the analytical variability of the qualitative Anti-NC assay.

Conclusions
Results from anti-NC antibodies are stable during short-term storage at <−70 °C and 2–10 °C. After long-term storage, a slight increase in sensitivity could not be ruled out.
Hispanic-American dialectology in the 16th century. Penetration of Americanisms in Nicolas Monardes’ Historia Medicinal
Authors: Cáceres-Lorenzo María-Teresa 
Published: November 2022

Abstract

Historia medicinal (1565–1574) is an educational work that sought to promote knowledge of American phytotherapy for academic and economic purposes. This educational aim was accomplished after its publishing success in Spain and other European countries. Our objective is to examine the American words Nicolas Monardes chose and assess the degree of penetration of Native American loanwords and Americanised hispanicisms which have become fully incorporated into current American Spanish. The degree of penetration is measured through the variables with which they appear in the text (loanwords, number of appearances with or without explanation, used in medicine, medical term). 93 words were analysed using quantitative methodology and different degrees of penetration were detected. These terms included Native American loanwords, mediaeval medical hispanicisms, Spanish words created to describe American reality and neologisms that were widespread in the 16th century.
Postposed topic specification across the Sahara. An areal phenomenon
Authors: Lafkioui Mena B. 
Published: November 2022

Abstract
In the present study, I argue that post-posed topic specification (PTS) across the Sahara is an areal phenomenon and that in the case of Southern Tamazight (i.e., Tuareg & Zenaga) it is an innovation generated by pattern replication. On the other hand, the required matter for PTS formation in Southern Tamazight is generally provided by Tamazight itself by means of system-internal developments involving the following predominant grammaticalisation track, that is, [*modality markers > topic specifiers]. I also show that full convergence has taken place in these Southern Tamazight languages, which has affected their linguistic typology on the morphological, syntactic, and pragmatic level. Moreover, the study accounts for the significance of the functional parameter of contrast in the development of these topic specifiers and hence confirms the importance of system-based factors in language change.
Luxemburger Wirtshausnamen
Authors: Krier Fernande 
Published: November 2022

Abstract
This study deals with a rarely discussed lexicological and semantic issue, Luxemburgish names of inns. I was astonished by their large number and their diversification. In the Middle Ages, many people could not read, therefore an inn was indicated by a sign, for instance that of a raven that gave it its name. The name of the inn could give its situation in the village in order to help foreigners to find their way, for instance “At the market”. I examine historical relations, too, like “way of the Romans” and, on the other hand, names of animals, such as “At the raven”. Last not least I have discovered funny names like “kitchen of the devil” and original names, for instance ”Why not?” or “The peppercorn”. I don’t neither forget a very old house name, “Plutoshaff”, founded in the eighteenth century by Franz Plutot, a personality of the village.
Construction of mercury ion fluorescence system in water samples and art materials and fluorescence detection method for rhodamine B derivatives
Authors: Wang Zhankun , Hu Yanqiu , Zhou Xiaoxuan , Lv Yuguang 
Published: November 2022

Abstract
At present, the research on fluorescent molecular probe has become a hot topic in the field of environmental science, chemical materials, medicine, and other fields. Therefore, the detection of industrial mercury-containing wastewater (Hg2+) is of great significance. In this article, the fluorescent probe is used to detect mercury ions, and when compared with the traditional detection method, the fluorescent probe has the advantage of operation such as the effect of simplicity is evident. The experiments first synthesized rhodamine B derivatives and then the synthesized rhodamine B derivative fluorescent molecular probes were constructed and used to detect the mercury ions in water sample and oil paints. It was demonstrated that rhodamine B-derived probes have been constructed by UV and fluorescence spectroscopy. The different metal ions and rhodamine B-derived fluorescent molecular probes were compounded, resulting in the appearance of fluorescence peak centered at 583 nm only after the addition of metallic mercury ions with almost no response from other ions. The mercury ion rhodamine B derivative is more responsive to metallic mercury ions.
HOXA10 enhances cell proliferation and suppresses apoptosis in esophageal cancer via activating p38/ERK signaling pathway
Authors: Jiang Lifeng , Yang Qixian 
Published: November 2022

Abstract
Esophageal cancer (EC) is an extremely aggressive malignant tumor. Homeobox A10 (HOXA10) is highly expressed and plays an important role in a variety of tumors. However, the function of HOXA10 in EC remains unclear. In this study, HOXA10 was observed to highly express in EC tissues and cells. Interestingly, the CCK-8 assay, flow cytometry, and colony formation assay confirmed that overexpression of HOXA10 promoted proliferation and suppressed cell apoptosis in EC cells. More importantly, the western blot assay indicated that the phosphorylation levels of ERK and p38 were elevated in EC cells overexpressed HOXA10, indicating that overexpression of HOXA10 activated p38/ERK signaling pathway in EC cells. These findings concluded that HOXA10 aggravated EC progression via activating p38/ERK signaling pathway, providing a potential therapeutic target for EC.
Ideophones in Arusa Maasai: Syntax, morphology, and phonetics
Authors: Karani Michael , Andrason Alexander 
Published: November 2022

Abstract
The present article is dedicated to the syntax, morphology, and phonetics of ideophones in Arusa Maasai. After examining the compliance of 69 ideophonic lexemes with the typologically driven prototype of an ideophone, the authors conclude that Arusa ideophones may range from canonical to non-canonical even within a single language module. When syntax, morphology, and phonetics are considered jointly, holophrastic and asyntagmatic ideophones are more canonical than ideophones used as verbal modifiers and parts of complex predicates, which are, in turn, more canonical than predicative ideophones. The extent of canonicity is inversely correlated with the systematicity and integration of ideophones in sentence grammar and their diffusion into other lexical classes: predicative ideophones have been fully incorporated into the category of verbs; for ideophones employed as verbal modifiers, a comparable incorporation into the category of adverbs has not been completed; for all the other types, especially holophrastic and asyntagmatic, ideophones still maintain their categorical individuality. Overall, ideophones constitute an “old” category in Arusa, one that is well advanced on its grammaticalization cline.
In vitro evaluation of 2-pyrazoline derivatives as DPP-4 inhibitors
Authors: Temel Halide Edip , Altıntop Mehlika Dilek , Sever Belgin , Özdemir Ahmet , Akalın Çiftçi Gülşen 
Published: November 2022

Abstract

Objectives
In this study, the synthesis of three pyrazoline derivatives and the evaluation of their inhibitory effects on dipeptidyl peptidase (DPP-4) were aimed.

Methods
Pyrazoline-based compounds (1–3) were obtained via the reaction of 1-(2-furyl)-3-(1,3-benzodioxol-5-yl)-2-propen-1-one with 4-substituted phenylhydrazine hydrochloride. The DPP-4 inhibitory effects of compounds 1–3 were determined with a fluorometric assay using Gly-Pro-aminomethylcoumarin as the fluorogenic substrate. The cytotoxicity of compounds 1–3 on L929 mouse fibroblast (healthy) cell line was evaluated using MTT assay.

Results
1-(4-Methylsulfonylphenyl)-3-(2-furyl)-5-(1,3-benzodioxol-5-yl)-2-pyrazoline (2) exhibited the highest DPP-4 inhibitory activity (IC50=5.75 ± 0.35 µM). Moreover, compound 2 exerted no significant cytotoxicity against L929 cells (IC50=34.33 ± 7.09 µM).

Conclusions
Target compounds exhibited moderate DPP-4 inhibitory activity and compound 2 was identified as the most active compound.