bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prevalance Overview of ARI Sufferers in the Mining Environment at Cinta Jaya Inc, Molawe District
Authors: Adryana Vita , Azizi Jayadipraja Erwin , Sriningsih Chun , Suatia Waode 
Published: April 2022

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Introduction: Mining activities also cause traffic disturbances due to the back and forth of operational vehicles and transporters going and out of the special terminal area,causing a decrease in air quality and noise which can increase the prevalence of Ari based on data from molawe health center with a population 0f 5291,30 ARI patient, cases in 2019 and there were 37 cases in 2020 and 42 casess in 2021 this can 2021.this affect the health status of the community in the mining envirotment of the molawe sub-district
Method: The method used in this study is descriptive research method. The descriptive method was chosen because the study carried out aims to describe the data naturally. The data used are secondary data and documents from the Health Office of Southeast Sulawesi Province, Limbo Health Center, Molawe District, 2019 - 20121. North Konawe Regency, Southeast Sulawesi Province.
Result: It was concluded that there was a relationship between age and gender with the incidence of ARI in infants Smoking Habits From 42 respondents, the results showed that most of the respondents were exposed to cigarette smoke, namely 34 respondents or 81.0% and the remaining only 8 respondents (19%) who had no exposure to cigarette smoke. Based on these data, it can be concluded that most children under five are exposed to cigarette smoke.
Conclusion: The factors that influence the increasing prevalence of ARI are redidental density,smoking/behavior and mining activities that are very at risk for suffering from ARI disease
miR-34a-5p inhibits the malignant progression of KSHV-infected SH-SY5Y cells by targeting c-fos
Authors: Wu Shuyuan , Wu Zhaofu , Xu Huiling , Zhang Jinli , Gu Wenyi , Tan Xiaohua , Pan Zemin , Cao Dongdong , Li Dongmei , Yang Lei , Li Dongmei , Pan Yuanming 
Published: April 2022

Background
We aimed to investigate the effects of miR-34a-5p on c-fos regulation mediating the malignant behaviors of SH-SY5Y cells infected with Kaposi’s sarcoma-associated herpesvirus (KSHV).

Methods
The KSHV-infected (SK-RG) and uninfected SH-SY5Y parent cells were compared for differentially expressed miRNAs using transcriptome sequencing. Then miR-34a-5p was upregulated in SK-RG cells by the miRNA mimics transfection. Cell proliferation ability was determined by MTT and plate clone assays. The cell cycle was assessed by flow cytometry analysis, and CDK4, CDK6, cyclin D1 levels were determined by Western blot analysis. The migration behavior was detected by wound healing and transwell assays. The protein levels of MMP2 and MMP9 were measured by Western blot analysis. The regulation of c-fos by miR-34a-5p was detected by the dual-luciferase reporter gene assay. Rescue assays were carried out by upregulating c-fos in miR-34a-5p-overexpressing SK-RG cells. KSHV DNA copy numbers and relative virus gene expressions were detected. Xenograft tumor experiments and immunohistochemistry assays were further used to detect the effects of miR-34a-5p.

Results
miR-34a-5p was lower in SK-RG cells. Restoration of miR-34a-5p decreased cell proliferation and migration, leading to a G1 cell cycle arrest and down-regulation of CDK4/6, cyclin D1, MMP2, MMP9. KSHV copy number and expression of virus gene including latency-associated nuclear antigen (LANA), replication and transcription activator (RTA), open reading frame (K8.1), and KSHV G protein-coupled receptor (v-GPCR) were also reduced. Furthermore, c-fos is the target of miR-34a-5p, while enhanced c-fos weakened cellular behaviors of miR-34a-5p-overexpressing cells. Xenograft experiments and immunohistochemistry assays showed that miR-34a-5p inhibited tumor growth and virus gene expression.

Conclusion
Upregulated miR-34a-5p in KSHV-infected SH-SY5Y cells suppressed cell proliferation and migration through down-regulating c-fos. miR-34a-5p was a candidate molecular drug for KSHV-infected neuronal cells.
Study of Productivity and Economics of Pearl Millet (Pennisetum glaucum L.) Variety ABV -04 in Relation to Nitrogen and Phosphorus
Authors: Venkata Sai Ganesh Mannepu , Singh Rajesh , Indu Thakur , Dwivedi Kalyani 
Published: April 2022

Background: Pearl millet can thrive in a wide range of local conditions. In areas where sorghum cannot thrive, pearl millet is a viable alternative. Sorghum and maize can't compete with pearl millet when it comes to soil moisture utilisation and heat tolerance.
Objectives: Effects of nitrogen and phosphorus on yield and economics of pearl millet
Methods: With the goal of studying the effect of nitrogen and phosphorus on yield and economics of Pearl millet (Pennisetum glaucum L.) Var. ABV - 04 under a Randomized block design with 9 treatments (T1-T The experimental results revealed that 120 kg N/ha + 60 kg P/ha produced ear head length (20.77 cm), number of grains/ear head (1972.0), grain yield (2.68 t/ha), harvest index (41.49 percent).T9 120 kg N/ha + 60 kg P/ha produced greater net returns (95,132.00 INR/ha), gross returns (1,36,544.00 INR/ha), and benefit-to-cost ratios (2.30).
Conclusion: 120 kg N/ha + 60 kg P/ha yielded the highest net return (95,132.00INR /ha), gross return (1,36,544.00INR /ha), and benefit: cost ratio than any other combination of nutrition source (2.30).
Unusual Aetiology of Vocal Process Granuloma in a Child
Authors: Olusoga-Peters Oluwapelumi O. , Akinola Moses Ayodele , Nwadiokwu John Ifeanyi , Binuyo Tolulope .O , Oguntade Florence A. O, 
Published: April 2022

Background: Vocal cord granuloma commonly arises following trauma or irritation from endotracheal intubation and reflux disease. Other uncommon causes are granuloma following voice abuse and foreign body in the larynx. Vocal process granuloma has however not been reported following blunt anterior neck trauma.
Case Presentation: We present a case of vocal cord granuloma following an anterior neck trauma. The patient is a seven year old boy who presented with persistent hoarseness and stridor post neck injury of three months duration. Systemic steroid has been used prior to presentation with temporary improvement. The direct laryngoscopy done under general anaesthesia revealed masses on both vocal processes, which were successfully excised surgically. There was total resolution of presenting complaints after surgery with no symptoms suggestive of recurrence six month post operation.
Conclusion: Post intubation and laryngopharyngeal reflux disease are common causes of vocal process granuloma. However, there is need to suspect granuloma formation following blunt anterior neck trauma for immediate conservative management avoiding the need for surgical intervention when patient present with upper airway obstruction.
Multi‐Color 3D Printing via Single‐Vat Grayscale Digital Light Processing
Authors: Peng Xirui , Yue Liang , Liang Sizhuang , Montgomery Stuart , Lu Chunliang , Cheng Chieh‐Min , Beyah Raheem , Zhao Ruike Renee , Qi H. Jerry 
Published: April 2022

AbstractDigital light processing (DLP) is a high‐resolution, high‐speed additive manufacturing method that builds 3D parts by selectively curing photopolymerizable resins layer‐by‐layer. To achieve multi‐color DLP printing, researchers have used multiple switchable resin vats. However, these methods require complex vat switching devices and cleaning manipulations, leading to low efficiency. Therefore, it remains a challenge to achieve multi‐color DLP 3D printing efficiently. In this study, a single‐vat multi‐color DLP 3D printing by using an anthraquinone‐based dye is realized. The dye can be oxidized by the free radicals released from photoinitiators under ultraviolet light and change the color from blue to yellow. This color‐changing mechanism permits a graded spectrum of colors as concomitants of the photopolymerization process during DLP printing by controlling the light dose without using extra vats or devices. Multi‐color demonstrations, such as engineering stress simulation results in 3D and multi‐color vases, are successfully fabricated, showing great versatility and efficiency.
Enriched d‐Band Holes Enabling Fast Oxygen Evolution Kinetics on Atomic‐Layered Defect‐Rich Lithium Cobalt Oxide Nanosheets
Authors: Zheng Xiaobo , Chen Yaping , Lai Weihong , Li Peng , Ye Chenliang , Liu Nana , Dou Shi Xue , Pan Hongge , Sun Wenping 
Published: April 2022

AbstractDeveloping a reliable synthesis strategy to concurrently realize electronic structure modulation and two‐dimensionalization of materials is of paramount significance yet still challenging. Herein, a facile and universal strategy is reported to fabricate defect‐abundant atomic‐layered materials with unique electronic structures by mechanical shear‐assisted exfoliation. As a proof‐of‐concept demonstration, atomic‐layered defect‐rich LiCoO2 nanosheets (AD‐LCO) are successfully synthesized, which enable accelerated oxygen evolution kinetics with a substantially decreased oxygen evolution reaction overpotential by 184 and 216 mV at 10 and 50 mA cm–2, respectively. X‐ray absorption spectroscopy suggests that AD‐LCO possesses more d‐band holes and enhanced Co‐O covalency. Density functional theory calculations reveal that the presence of Co lattice vacancies can optimize the adsorption kinetics of intermediates, consequently lowering the energy barrier of the rate‐determining step. Importantly, this method has universal applicability to the fabrication of other ultrathin defect‐rich 2D materials such as BN, WS2, and MoS2. The study has potential implications for offering novel insights into the rational design of ultrathin 2D materials with abundant surface defects for various applications.
Hybridization of 2D Nanomaterials with 3D Graphene Architectures for Electrochemical Energy Storage and Conversion
Authors: Yun Qinbai , Ge Yiyao , Chen Bo , Li Lujiang , Wa Qingbo , Long Huiwu , Zhang Hua 
Published: April 2022

AbstractSince the discovery of graphene, diverse kinds of 2D nanomaterials have been explored and exhibited great promise for application in electrochemical energy storage and conversion. However, the restacking of 2D nanomaterials severely reduces their exposed active sites and thus impairs their electrochemical performance. Moreover, except for graphene, a large number of 2D nanomaterials normally possess unsatisfactory electrical conductivity. One of the effective strategies to address the aforementioned shortcomings is to hybridize 2D nanomaterials with 3D graphene architectures since large specific surface area and rapid transport pathways for electrons, ions, and mass can be achieved in the obtained hybrid materials. This review summarizes the typical strategies to hybridize 2D nanomaterials with 3D graphene architectures and then highlights the application of these hybrid materials in rechargeable batteries, supercapacitors, and electrocatalytic water splitting. The challenges and future research directions in this research area are also discussed.
Effect of Heteroatom and Charge Reconstruction in Atomically Precise Metal Nanoclusters on Electrochemical Synthesis of Ammonia
Authors: Han Meng , Guo Minghao , Yun Yapei , Xu Yujun , Sheng Hongting , Chen Yanxia , Du Yuanxin , Ni Kun , Zhu Yanwu , Zhu Manzhou 
Published: April 2022

AbstractAlthough atomically precise metal nanoclusters (NCs) are widely used in catalysis, a wide gap exists between state‐of‐the‐art performance and practical requirements. Regulating the intrinsic activity of NCs is critical for the rational design and synthesis of highly efficient catalysts. Herein, M4Ni2 NCs (M = Au, Ag) with improved electrocatalytic nitrogen reduction reaction (NRR) activity due to the introduction of Ni are synthesized, which significantly suppresses the H2 generation competition reaction. Ag4Ni2 NCs exhibit the best NRR activity at −0.2 V versus RHE with a NH3 yield of 23.32 µg mg–1 h–1 and a faradic efficiency of 78.97% due to the higher N2 chemisorption ability and lower rate‐determining barrier. Meanwhile, ligand partial detachment of NCs during electrocatalysis offers exposed active sites and induces the charge reconstruction, also contributing to the outstanding NRR performance. Based on the precise composition and structure, deep insights into the NRR mechanism at the atom level are provided by in situ Fourier‐transformed infrared spectroscopy and ab initial calculation. The study presents an efficient strategy based on heteroatom doping and charges reconstruction to promote NCs catalytic performance.
3D Upconversion Barcodes for Combinatory Wireless Neuromodulation in Behaving Animals
Authors: Lin Xudong , Sun Tianying , Tang Minghui , Yang Anqi , Yan‐Do Richard , Chen Da , Gao Yaobin , Duan Xin , Kai Ji‐Jung , Wang Feng , Shi Peng 
Published: April 2022

AbstractUpconversion techniques offer all‐optical wireless alternatives to modulate targeted neurons in behaving animals, but most existing upconversion‐based optogenetic devices show prefixed emission that is used to excite just one channelrhodopsin at a restricted brain region. Here, a hierarchical upconversion device is reported to enable spatially selective and combinatory optogenetics in behaving rodent animals. The device assumes a multiarrayed optrode format containing engineered upconversion nanoparticles (UCNPs) to deliver dynamic light palettes as a function of excitation wavelength. Three primary emissions at 477, 540, and 654 nm are selected to match the absorption of different channelrhodopsins. The UCNPs are barcode assembled to multiple nanomachined optical pinholes in a microscale pipette device to allow remotely addressable, spectrum programmable, and spatially selective optical interrogation of complex brain circuits. Using the unique device, the basolateral amygdala and caudoputamen circuits are selectively modulated and the associated fear or anxiety behavior in freely behaving rodents is successfully differentiated. It is believed that the 3D barcode upconversion device would be a great supplement to current optogenetic toolsets and opens up new possibilities for sophisticated neural control.
A Polyvalent Peptide CD40 Nanoagonist for Targeted Modulation of Dendritic Cells and Amplified Cancer Immunotherapy
Authors: Mamuti Muhetaerjiang , Wang Yi , Zhao Yong‐Dan , Wang Jia‐Qi , Wang Jie , Fan Yan‐Lei , Xiao Wu‐Yi , Hou Da‐Yong , Yang Jia , Zheng Rui , An Hong‐Wei , Wang Hao 
Published: April 2022

AbstractTargeted immunomodulation through biomolecule‐based nanostructures, especially to dendritic cells (DCs), holds great promise for effective cancer therapy. However, construction of high‐performance agonist by mimicking natural ligand to activate immune cell signaling is a great challenge so far. Here, a peptide‐based nanoagonist toward CD40 (PVA‐CD40) with preorganized interfacial topological structure that activates lymph node DCs efficiently and persistently, achieving amplified immune therapeutic efficacy is described. The on‐site fabrication of PVA‐CD40 is realized through the click conjugation of two functional peptides including the “CD40 anchoring arm” and the “assembly‐driving motor.” The resultant polyvalent interface rapidly triggers the receptor oligomerization and downstream signaling. Strikingly, one shot administration of PVA‐CD40 elicits maturation period of DCs up to 2.3‐fold comparing to that of CD40 antibody. Finally, combining the PVA‐CD40 with anti‐PD‐1 antibody results in subsequent inhibition of tumor growth in both B16F10 and 4T1 mice tumor models with survival rate up to 37%, while none of the mice survives in the clinically relevant CD40 mAb and anti‐PD‐1 combination‐treated group. It is envisioned that the fabrication of antibody‐like superstructures in vivo provides an efficient platform for modulating the duration of immune response to achieve optimal therapeutic efficacy.
PET‐CT Imaging of Polymeric Nanoparticle Tumor Accumulation in Patients
Authors: Miedema Iris H. C. , Zwezerijnen Gerben J. C. , Huisman Marc C. , Doeleman Ellen , Mathijssen Ron H. J. , Lammers Twan , Hu Qizhi , van Dongen Guus A. M. S. , Rijcken Cristianne J. F. , Vugts Danielle J. , Menke‐van der Houven van Oordt C. Willemien 
Published: April 2022

AbstractSeveral FDA/EMA‐approved nanomedicines have demonstrated improved pharmacokinetics and toxicity profiles compared to their conventional chemotherapeutic counterparts. The next step to increase therapeutic efficacy depends on tumor accumulation, which can be highly heterogeneous. A clinical tool for patient stratification is urgently awaited. Therefore, a docetaxel‐entrapping polymeric nanoparticle (89Zr‐CPC634) is radiolabeled, and positron emission tomography/computed tomography (PET/CT) imaging is performed in seven patients with solid tumors with two different doses of CPC634: an on‐treatment (containing 60 mg m−2 docetaxel) and a diagnostic (1–2 mg docetaxel) dose (NCT03712423). Pharmacokinetic half‐life for 89Zr‐CPC634 is mean 97.0 ± 14.4 h on‐treatment, and 62.4 ± 12.9 h for the diagnostic dose (p = 0.003). At these doses accumulation is observed in 46% and 41% of tumor lesions with a median accumulation in positive lesions 96 h post‐injection of 4.94 and 4.45%IA kg−1 (p = 0.91), respectively. In conclusion, PET/CT imaging with a diagnostic dose of 89Zr‐CPC634 accurately reflects on‐treatment tumor accumulation and thus opens the possibility for patient stratification in cancer nanomedicine with polymeric nanoparticles.
Near‐Infrared Light‐Emitting Diodes utilizing a Europium‐Activated Calcium Oxide Phosphor with External Quantum Efficiency of up to 54.7%
Authors: Qiao Jianwei , Zhang Shuai , Zhou Xinquan , Chen Weibin , Gautier Romain , Xia Zhiguo 
Published: April 2022

AbstractNear‐infrared (NIR) luminescence materials with broadband emissions are necessary for the development of light‐emitting diodes (LEDs) based light sources. However, most known NIR‐emitting materials are limited by their low external quantum efficiency. This work demonstrates how the photoluminescence quantum efficiency of europium‐activated calcium oxide (CaO:Eu) NIR phosphor can be significantly improved and stabilized at operating temperatures of LEDs. A carbon paper wrapping technology is innovatively developed and used during the solid‐state sintering to promote the reduction of Eu3+ into Eu2+. In parallel, the oxygen vacancies in the CaO lattice are repaired utilizing GeO2 decomposition. Through this process, a record‐high external quantum efficiency of 54.7% at 740 nm is obtained with a thermal stability greatly improved from 57% to 90% at 125 °C. The as‐fabricated NIR‐LEDs reach record photoelectric efficiency (100 mA@23.4%) and output power (100 mA @ 319.5 mW). This discovery of high‐performance phosphors will open new research avenues for broadband NIR LED light sources in a variety of photonics applications.
Metal‐Organic Chemical Vapor Deposition of Oxide Perovskite Films: A Facile Route to Complex Functional Systems
Authors: Lo Presti Francesca , Pellegrino Anna L. , Malandrino Graziella 
Published: April 2022

AbstractPerovskite oxide type materials exhibit a great profusion of unique functional properties and for this reason they have been named inorganic chameleon. Nevertheless, their actual applications require the availability of these systems in thin‐film form synthesized through a simple, scalable, and straightforward technique. Metal‐organic chemical vapor deposition (MOCVD) has been shown to be an outstanding process to prepare thin films of multi‐component oxides. Herein, the focus is devoted to oxide perovskite thin films on both single crystal and non‐single crystal substrates through MOCVD processes. This study discusses the principles and the basic rules governing conventional, plasma‐enhanced, and liquid‐assisted MOCVD processes. Among a plethora of oxide perovskites, several classes of functionalities belonging to the perovskite class: from superconductors to dielectrics and giant‐k dielectrics, from colossal magnetoresistance to ionic conductors, piezoelectrics and ferroelectrics, are explored in detail.
Ultraflexible Photothermal Superhydrophobic Coating with Multifunctional Applications Based on Plasmonic TiN Nanoparticles
Authors: Wang Baoqing , Jing Zhimin , Zhao Mingxi , Yu Peng , Ashalley Eric , Li Peihang , Ma Cuiping , Tong Xin , Caputo Roberto , Govorov Alexander O. , Xu Hongxing , Wang Zhiming M. 
Published: April 2022

AbstractPhotothermal superhydrophobic coatings are essential for a variety of applications including anti‐icing and light‐driven self‐propelled motion. However, achieving a flexible and durable superhydrophobic coating with high photothermal efficiency and long‐term stability is still challenging. Herein, a facile and eco‐friendly approach to realizing a superhydrophobic coating with excellent flexibility is proposed. The coating is obtained by spraying titanium nitride (TiN) nanoparticles embedded in polydimethylsiloxane (PDMS) solution onto various substrates. A tight binding between the substrate and nanoparticles occurs that offers the coating the mechanical robustness to endure bending, twisting, abrasion, and tape peeling. The water repellency is retained even after 500 cycles of bending–twisting tests. Combined with the micro–nanoscale porous structure of the surface and plasmonic property of TiN nanoparticles, the coating shows excellent superhydrophobicity and high photothermal conversion properties. The equilibrium temperature of the coating is as high as 130 °C at room temperature under 1 W cm−2 of 808 nm near‐infrared laser irradiation. Due to its flexible property, the coating can be easily applied to irregular surfaces, which, together with the excellent anticorrosion, anti‐icing, and defrosting performances, makes it a reliable resource for multifunctional applications. This work offers a novel technological approach to flexible devices, wearable electronics, and smart textiles.
Efficient Prediction of Grain Boundary Energies from Atomistic Simulations via Sequential Design
Authors: Kroll Martin , Schmalofski Timo , Dette Holger , Janisch Rebecca 
Published: April 2022

AbstractWith the goal of improving data based materials design, it is shown that by a sequential design of experiment scheme the process of generating and learning from the data can be combined to discover the relevant sections of the parameter space. The application is the energy of grain boundaries as a function of their geometric degrees of freedom, calculated from a simple model, or via atomistic simulations. The challenge is to predict the deep cusps of the energy, which are located at irregular intervals of the geometric parameters. Existing sampling approaches either use large sets of datapoints or a priori knowledge of the cusps' positions. By contrast, the authors' technique can find unknown cusps automatically with a minimal amount of datapoints. Key point is a Kriging interpolator with Matérn kernel to estimate the energy function. Using the jackknife variance, the next point in the sequential design is a compromise between sampling the region of largest fluctuations and avoiding a clustering of datapoints. In this way, the cusps of the energy can be found within only a few iterations, and refined as desired. This approach will be advantageous for any application with strong, localized fluctuations in the values of the unknown function.
Comment on “Electron Density Analysis for the H2+System Confined by Hard Walls: The Chemical Bond under Extreme Conditions” [Ann. Phys. (Berlin) 2019,531, 1800476]
Authors: Pupyshev Vladimir I. , Montgomery H. E. 
Published: April 2022

AbstractThe numerical results of Hernandez‐Esparza et al. demonstrate that the maximum electron density of the H2+molecule confined by hard walls is sometimes displaced away from the nuclei of the molecule. It is here shown analytically that hard confinement can significantly change the ground state electron density. For the free system, the electronic energyE(without the internuclear repulsion term) is strongly negative for all internuclear distancesR, while for a system under tight confinement, a critical point of QTAIM type (3,−3) occurs whenE> 0.