bluuebunny/crossref_metadata_2025_split huggingface dataset:
Incidence, risk factors and clinical outcomes of septic acute renal injury in cancer patients with sepsis admitted to the ICU: A retrospective study
Authors: Yang Yong , Dong Jun , Chen Xiaojie , Chen Renxiong , Wang Hongzhi 
Published: December 2022

BackgroundThe purpose of this study was to clarify the incidence, risk factors, and clinical outcomes of septic acute kidney injury (AKI) in cancer patients with sepsis admitted to the intensive care unit (ICU).MethodsA total of 356 cancer patients admitted to the ICU due to sepsis from January 2016 to October 2021 were analyzed retrospectively. According to the incidence of septic AKI, all patients were divided into the non-AKI group (n = 279) and the AKI group (n = 77). The clinical data after ICU admission were compared between the above two groups, and the risk factors and the clinical outcomes of septic AKI in the ICU were identified.ResultsThe incidence of septic AKI in all patients was 21.6% (77/356). LASSO regression and logistic regression all showed that lactate, sequential organ failure assessment (SOFA) score and septic shock were closely related to the occurrence of septic AKI. In terms of clinical outcomes after ICU admission, the rate of mechanical ventilation (MV) and continuous renal replacement therapy (CRRT), MV time, hospitalization time and 28-day mortality in the ICU were significantly higher in the septic AKI group than in the non-septic AKI group. Among the three subgroups of septic AKI (AKI combined with septic shock, septic cardiac dysfunction or acute respiratory failure), the mortality of patients in the subgroup of AKI combined with septic shock was significantly higher than others. CRRT has no significant effect on the short-term outcome of these patients.ConclusionLactate level, SOFA score and septic shock were closely related to the occurrence of septic AKI in the ICU. The clinical outcomes within 28 days after ICU admission of cancer patients with septic AKI were worse than those without septic AKI. The short-term outcome was worse in patients with septic AKI complicated with septic shock. CRRT does not have any significant effect on the short-term prognosis of cancer patients with septic AKI in the ICU.
Gut bacterial communities and their assembly processing in Cnaphalocrocis medinalis from different geographic sources
Authors: Yang Yajun , Liu Xiaogai , Guo Jiawen , Xu Hongxing , Liu Yinghong , Lu Zhongxian 
Published: December 2022

IntroductionThe insect gut harbors numerous microorganisms that may have functions in development and reproduction, digestion, immunity and protection, and detoxification. Recently, the influence factors on gut microbiota were evaluated in the rice leaffolderCnaphalocrocis medinalis, a widespread insect pest in paddy fields. However, the relationship between gut microbiota composition and geography is poorly understood inC. medinalis.MethodsTo reveal the patterns ofC. medinalisgut bacterial communities across geographic sources and the ecological processes driving the patterns,C. medinaliswere sampled from six geographic sources in China, Thailand, and Vietnam in 2016, followed by gut bacterial 16S ribosomal RNA gene sequencing.ResultsA total of 22 bacterial phyla, 56 classes, 84 orders, 138 families, 228 genera, and 299 species were generated inC. medinalisfrom six geographic sources. All alpha diversity indices differed among the samples from different geographic sources. Analysis of similarity (ANOSIM) and permutational multivariate analysis of variance (PERMANOVA) both revealed significant differences in the gut microbiota ofC. medinalisfrom six geographic sources. A total of 94 different taxa were screened as indicators for the gut microbiota ofC. medinalisfrom six geographic sources by linear discriminant analysis effect size (LEfSe). The gene ontology (GO) pathways of the gut microbiota inC. medinalisdiffered among geographic sources. In total, the bacterial communities within geographic sources were mainly determined by stochastic processes, and those between geographic sources were mainly determined by deterministic processes.DiscussionThis study elucidates that geography plays a crucial role in shaping the gut microbiota ofC. medinalis. Thus, it enriches our knowledge of gut bacteria inC. medinalisand sheds light on the mechanisms underlyingC. medinalisgut microbial shifts across geography.
A coordinate-based meta-analysis of acupuncture for chronic pain: Evidence from fMRI studies
Authors: Yu Zheng , Wang Rong-Rong , Wei Wei , Liu Li-Ying , Wen Chuan-Biao , Yu Shu-Guang , Guo Xiao-Li , Yang Jie 
Published: December 2022

BackgroundChronic pain (CP) patients tend to represent aberrant functional brain activity. Acupuncture is an effective clinical treatment for CP, and some fMRI studies were conducted to discover the alternation of brain regions after acupuncture therapy for CP. However, the heterogeneity of neuroimaging studies has prevented researchers from systematically generalizing the central mechanisms of acupuncture in the treatment of CP.MethodsWe searched bibliographic databases, including PubMed, EMBASE, PsycINFO, Web of Science Core Collection, ScienceDirect, China Academic Journal Network Publishing Database, etc., and trials registration platforms (From inception to September 1st, 2022). Two independent researchers assessed the study's bias and quality. Furthermore, activation likelihood estimation (ALE) analysis was applied to explore aberrant brain functional activity and acupuncture's central mechanism for CP.ResultsTotally 14 studies with 524 CP patients were included in the study. ALE analysis showed that CP patients presented with decreased ALFF/ReHo in the precuneus, posterior cingulate cortex, right inferior parietal lobule, right superior temporal gyrus, cingulate gyrus, superior frontal gyrus, left medial frontal gyrus including medial prefrontal gurus, left middle frontal gyrus.ConclusionThis ALE meta-analysis pointed out that acupuncture could modulate the default mode network, the frontoparietal network to treat CP. This provided a systematic summary of the neuroimage biomarker of acupuncture for the treatment of CP.Systematic review registrationPROSPERO, identifier: CRD42021239633.
A network meta-analysis on the improvement of cognition in patients with vascular dementia by different acupuncture therapies
Authors: Wen Jiayu , Cao Yu , Chang Surui , Huang Qiaoyi , Zhang Zhen , Wei Wei , Yao Jiuxiu , Pei Hui , Li Hao 
Published: December 2022

IntroductionThe second most prevalent cause of dementia is vascular dementia (VaD). Furthermore, acupuncture is a relatively safe and effective traditional therapy for individuals with VaD. We performed a network meta-analysis to assess the effectiveness and safety of various acupuncture therapies for VaD based on existing research.MethodsWe searched six electronic databases to screen for randomized controlled trials (RCTs) comparing different acupuncture treatments in VaD patients. The Cochrne tool (Review Manager 5.3) was used to evaluate the risk of bias of the included RCTs. Based on the Grading of Recommendations Assessment, Development and Evaluation framework, we assessed the confidence in the evidence using the Confidence In the results from Network Meta-Analysis approach. We used the frequency approach to perform the network meta-analysis. Data were analyzed using R 4.1.1.ResultsIn total, we included 46 eligible studies. The results of the network analysis showed that the combined interventions of moxibustion (MB) with body acupuncture (BA) (MB + BA) and electroacupuncture (EA) with scalp acupuncture (SA) with BA (EA + SA + BA) were more effective in improving cognitive functions and activities of daily living compared with SA or BA alone. However, in the subgroup analysis, EA + SA + BA showed better efficacy in short- and mid-term acupuncture compared with other acupuncture therapies.ConclusionCombined acupuncture therapy may be a safe and effective intervention for individuals with VaD, and MB + BA and EA + SA + BA appear to be the most effective interventions. However, because the analysis of this study was based on low-to-moderate evidence, there remains no strong supporting evidence. Thus, high-quality, large-scale, and long-term studies should be conducted in the future to assess the effectiveness and safety of acupuncture in VaD.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/, identifier: CRD42022354573.
Iron status and mental disorders: A Mendelian randomization study
Authors: Qiu Jiaqi , Lian Fuzhi , Fang Xuexian 
Published: December 2022

BackgroundMental disorders account for an enormous global burden of disease, and has been associated with disturbed iron metabolism in observational studies. However, such associations are inconsistent and may be attributable to confounding from environmental factors. This study uses a two-sample Mendelian randomization (MR) analysis to investigate whether there is any causal effect of systemic iron status on risk of 24 specific mental disorders.MethodsGenetic variants with concordant relations to 4 biomarkers of iron status (serum iron, ferritin, transferrin saturation, and transferrin) were obtained from a genome-wide association study performed by the Genetics of Iron Status (GIS) consortium. Summary-level data for mental disorders were obtained from the UK Biobank. An inverse-variance weighted (IVW) approach was used for the main analysis, and the simple median, weighted median and MR-Egger methods were used in sensitivity analyses.ResultsGenetically predicted serum iron, ferritin, and transferrin saturation were positively associated with depression and psychogenic disorder, and inversely associated with gender identity disorders. A higher transferrin, indicative of lower iron status, was also associated with increased risk of gender identity disorders and decreased risk of psychogenic disorder. Results were broadly consistent when using multiple sensitivity analyses to account for potential genetic pleiotropy.ConclusionOur findings offer a novel insight into mental health, highlighting a detrimental effect of higher iron status on depression and psychogenic disorder as well as a potential protective role on risk of gender identity disorders. Further studies regarding the underlying mechanisms are warranted for updating preventative strategies.
Association between sarcopenia and prognosis of hepatocellular carcinoma: A systematic review and meta-analysis
Authors: Jiang Chuan , Wang Yanyan , Fu Wei , Zhang Guozhuan , Feng Xiaoshan , Wang Xing , Wang Fang , Zhang Le , Deng Yang 
Published: December 2022

BackgroundSarcopenia, characterized by the loss of muscle mass, strength, and physical ability, occurs with aging and certain chronic illnesses such as chronic liver diseases and cancer. Sarcopenia is common in liver cirrhosis and hepatocellular carcinoma (HCC). Previous reports of association between sarcopenia and prognosis of HCC have been inconsistent. Therefore, the present systematic review and meta-analysis aimed to investigate the impact of sarcopenia on the survival of patients with HCC.MethodsA systematic literature search was conducted using PubMed, EMBASE, and Web of Science electronic databases from inception to May 1, 2022. We included retrospective or prospective studies investigating the association between sarcopenia and overall survival (OS) and/or progression free survival (PFS) of HCC. We applied the Quality in Prognosis Studies (QUIPS) instrument to evaluate the risk of bias and quality of included studies. The primary and secondary outcomes were the associations of sarcopenia with OS and PFS, respectively, expressed by a pooled hazard ratio (HR) and corresponding 95% confidence interval (CI). Subgroup analysis and sensitivity analysis were performed. We further evaluated the publication bias by the funnel plot and Begg’s test.ResultsA total of 42 studies comprising 8,445 patients were included. The majority of included studies were at an overall low risk of bias. The pooled prevalence of sarcopenia was 39% (95% CI: 33–45%) (n = 8,203). Sarcopenia was associated with an increased risk of shorter OS, with a pooled adjusted HR of 1.84 (95% CI: 1.62–2.09). An independent association between sarcopenia and reduced PFS was observed (HR = 1.33, 95% CI: 1.12–1.56).ConclusionThe prevalence of sarcopenia was approximately 39% among patients with HCC. Sarcopenia was independently associated with reduced OS and PFS in HCC irrespective of treatment modalities. It is imperative that interventions aimed at alleviating sarcopenia and restoring muscle mass be implemented in order to improve the survival of patients with HCC.Systematic review registration[https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42022337797], identifier [CRD42022337797].
Gou Qi Zi inhibits proliferation and induces apoptosis through the PI3K/AKT1 signaling pathway in non-small cell lung cancer
Authors: Zhang Lingling , Gong Yanju , Zhang Lei , Liang Bing , Xu Huan , Hu Wangming , Jin Zhong , Wu Xiao , Chen Xiongbin , Li Min , Shi Liangqin , Shi Yaping , Li Mingjian , Huang Yong , Wang Yong , Yang Lan 
Published: December 2022

BackgroundGou Qi Zi (Lycium barbarum) is a traditional herbal medicine with antioxidative effects. Although Gou Qi Zi has been used to prevent premature aging and in the treatment of non-small cell lung cancer (NSCLC), its mechanism of action in NSCLC remains unclear. The present study utilized network pharmacology to assess the potential mechanism of action of Gou Qi Zi in the treatment of NSCLC.MethodsThe TCMSP, TCMID, SwissTargetPrediction, DrugBank, DisGeNET, GeneCards, OMIM and TTD databases were searched for the active components of Gou Qi Zi and their potential therapeutic targets in NSCLC. Protein-protein interaction networks were identified and the interactions of target proteins were analyzed. Involved pathways were determined by GO enrichment and KEGG pathway analyses using the Metascape database, and molecular docking technology was used to study the interactions between active compounds and potential targets. These results were verified by cell counting kit-8 assays, BrdU labeling, flow cytometry, immunohistochemistry, western blotting, and qRT-PCR.ResultsDatabase searches identified 33 active components in Gou Qi Zi, 199 predicted biological targets and 113 NSCLC-related targets. A network of targets of traditional Chinese medicine compounds and potential targets of Gou Qi Zi in NSCLC was constructed. GO enrichment analysis showed that Gou Qi Zi targeting of NSCLC was mainly due to the effect of its associated lipopolysaccharide. KEGG pathway analysis showed that Gou Qi Zi acted mainly through the PI3K/AKT1 signaling pathway in the treatment of NSCLC. Molecular docking experiments showed that the bioactive compounds of Gou Qi Zi could bind to AKT1, C-MYC and TP53. These results were verified by experimental assays.ConclusionGou Qi Zi induces apoptosis and inhibits proliferation of NSCLC in vitro and in vivo by inhibiting the PI3K/AKT1 signaling pathway.
Biomechanics of the lead straight punch of different level boxers
Authors: Liu Yang , Zhu Zhiqiang , Chen Xiuxiu , Deng Chengyuan , Ma Xiujie , Zhao Bin 
Published: December 2022

We analyze and compare the differences in the biomechanical parameters between the lead straight punch and the index of force development of the lower extremities of boxers of different levels of ability. This can bridge the technical gap and provide insight and information for training strategies and athlete selection. To this end, a synchronized Vicon infrared 3D motion-capture system, two Kistler force platforms, and Kistler 8 target sensors were used for analysis. Sixteen boxers were recruited and sorted into an elite group (height 181.14 ± 3.01 cm, body mass 76.00 ± 10.028 kg) and a junior group (179.67 ± 5.84 cm, body mass 75.47 ± 12.19 kg), and their lead straight punch was then compared and analyzed. Three punch velocity indexes—peak velocity, contact velocity and Punching deceleration rate—six strength indexes—impulse, peak force, relative strength, peak time (frame), rate of force development (RFD), and movement time—and five exertion of both legs indexes— peak force, peak force/body mass, peak time, RFD index, and RFD/body mass index—were selected for analysis. Significant differences in the peak punch velocity and contact velocity were found between the two groups (7.162 ± 0.475 m•s−1vs. 6.317 ± 0.415 m•s−1, Cohen’s d = 1.89, p &lt; 0.01, 5.557 ± 0.606 m•s−1 vs. 4.874 ± 0.385 m•s−1, Cohen’s d = 1.34, p &lt; 0.05). Furthermore, significant differences were noted in the peak force [(1507.99 ± 411) N vs. (1035.45 ± 220) N, Cohen’s d = 1.43, p &lt; 0.01], relative strength [(21.04 ± 5.88) N•kg−1 vs. (15.61 ± 2.53) N•kg−1, Cohen’s d = 1.19, p &lt; 0.05], impulse [(88.61 ± 25.88) N•ms−1 and (60.53 ± 9.03) N•ms−1, Cohen’s d = 1.45, p &lt; 0.05], and RFD [(88.61 ± 25.88) N•ms−1 and (60.53 ± 9.03) N•ms−1, Cohen’s d = 1.45, p &lt; 0.05]. Among the four indexes of the lower extremities from two embedded Kistler force platforms, there were significant differences in the lead leg’s peak force/body mass [(19.68 ± 4.096) N•kg−1vs. (13.320 ± 2.223) N•kg−1, t = 3.902, Cohen’s d = 1.92, p &lt; 0.01], RFD index [(16.90 ± 3.269) N•ms−1vs. (10.28 ± 4.313) N•ms−1, Cohen’s d = 1.72, p &lt; 0.01], and RFD/body mass index [(23.47 ± 4.09%) N•ms−1Kg−1 vs. (15.38 ± 5.65%) N•ms−1Kg−1, Cohen’s d = 1.64, p &lt; 0.01]. There were no significant differences in the four indexes on the rear leg between the two groups (p &gt; 0.05). Based on the disparity in the effect of the lead straight punch and the biomechanical parameters of both lower extremities, the boxers must attach importance to sequential acceleration-braking training to improve the terminal velocity of the hand, and thus improve the contact velocity. Furthermore, it is advised that coaches and practitioners carefully consider increasing start-up strength training of the lead leg and attempt to improve the peak velocity of the lead straight punch. In addition, these biomechanical parameters can be used as criteria for the selection of boxers.
Class of hemorrhagic shock is associated with progressive diastolic coronary flow reversal and diminished left ventricular function
Authors: Elansary Noha N. , Stonko David P. , Treffalls Rebecca N. , Abdou Hossam , Madurska Marta J. , Morrison Jonathan J. 
Published: December 2022

Introduction: The relationship between coronary artery flow and left ventricular (LV) function during hemorrhagic shock remains unknown. The aim of this study was to quantify coronary artery flow directionality alongside left ventricular function through the four classes of hemorrhage shock.Methods: Following baseline data collection, swine were exsanguinated into cardiac arrest via the femoral artery using a logarithmic bleed, taking each animal through the four classes of hemorrhagic shock based on percent bleed (class I: 15%; class II: 15%–30%; class III: 30%–40%; class IV: &gt;40%). Telemetry data, left ventricular pressure-volume loops, and left anterior descending artery flow tracings over numerous cardiac cycles were collected and analyzed for each animal throughout.Results: Five male swine (mean 72 ± 12 kg) were successfully exsanguinated into cardiac arrest. Mean left ventricular end-diastolic volume, end-diastolic pressure, and stroke work decreased as the hemorrhagic shock class progressed (p &lt; 0.001). The proportion of diastole spent with retrograde coronary flow was also associated with class of hemorrhagic shock (mean 5.6% of diastole in baseline, to 63.9% of diastole in class IV; p &lt; 0.0001), worsening at each class from baseline through class IV. Preload recruitable stroke work (PRSW) decreased significantly in classes II through IV (p &lt; 0.001). Systemic Vascular Resistance (SVR) is associated with class of hemorrhage shock (p &lt; 0.001).Conclusion: With progressive classes of hemorrhagic shock left ventricular function progressively decreased, and the coronary arteries spent a greater proportion of diastole in retrograde flow, with progressively more negative total coronary flow. Preload recruitable stroke work, a load-independent measure of inotropy, also worsened in severe hemorrhagic shock, indicating the mechanism extends beyond the drop in preload and afterload alone.
The relationship of inclusive climate and peers' attitude on children with disabilities in China: A mediating role of empathy
Authors: Fu Wangqian , Xiao Yawen , Yin Cui , Zhou Tianqi 
Published: December 2022

ObjectivePeer attitude towards children with disabilities can significantly impact on the successful implementation of inclusive education. The current study examined the attitude of Chinese students toward peers with disabilities in relation to inclusive climate and empathy.MethodA total of 392 typically developing students (aging from 10 to 17 years old, with average age of 12.7) in primary and middle schools participated in the study by reporting the Inclusive Climate Scale, Peers Attitude to Students with Disabilities Scale, and Balanced Emotional Empathy Scale.ResultsWe found that students held a neutral attitude to peers with disabilities, and girls were more acceptable than boys. There were positive relationships among inclusive climate, empathy and attitude to classmates with disabilities. The mediation analysis showed that empathy played a partial mediation role between inclusive climate and the peers' attitude towards children with disabilities.ConclusionImplications for improving students' attitude on peers with disabilities were discussed in the paper.
Exercise is the dominant factor affecting the development of teenagers' eyesight—Based on the Bayesian model averaging
Authors: Liu Zhong-hui , Zhao Meng-fei , Ma Shuai , Li Yin , Sun Zhi-ying , Gao Lei 
Published: December 2022

ObjectiveThe model uncertainty may result in inconsistency about the environmental factors of myopia among students, and the Bayesian model average (BMA) is an effective way to eliminate it. We aimed to explore the influencing factors of myopia in primary and middle school students by BMA.MethodsThe data came from the 2021 National Surveillance of Common Diseases and Health Influencing Factors of students. By stratified random cluster sampling, the physical and mental health status of students in Tianjin and the factors affecting their physical health, such as diet, exercise, mental stress, school bullying, sleep time, and internet use, were investigated. The sample consisted of 8,457 primary school students, 8,191 junior middle school students, and 5,901 senior middle school students. Besides the physical examination, we used computer optometry (non-ciliary paralysis) to screen myopia. And we used BMA to select the risk factors through the BMS package in R.ResultsThe exercise was the only factor that affected the eyesight of junior and senior middle schoolers by BMA, with the posterior probability of 0.9736 and 0.9762, but not for the primary students. And we failed to select variables that affected eyesight in grades 4–6 of primary school.ConclusionThe exercise was a strong influencing factor for the eyesight of students in Tianjin's junior and senior middle schools.