bluuebunny/crossref_metadata_2025_split huggingface dataset:
Measurements of cosmic expansion and growth rate of structure from voids in the Sloan Digital Sky Survey between redshift 0.07 and 1.0
Authors: Woodfinden Alex , Nadathur Seshadri , Percival Will J , Radinovic Sladana , Massara Elena , Winther Hans A 
Published: September 2022

ABSTRACT
We present measurements of the anisotropic cross-correlation of galaxies and cosmic voids in data from the Sloan Digital Sky Survey (SDSS) Main Galaxy Sample, Baryon Oscillation Spectroscopic Survey (BOSS), and extended BOSS luminous red galaxy catalogues from SDSS Data Releases 7, 12, and 16, covering the redshift range 0.07 &lt; z &lt; 1.0. As in our previous work analysing voids in subsets of these data, we use a reconstruction method applied to the galaxy data before void finding in order to remove selection biases when constructing the void samples. We report results of a joint fit to the multipole moments of the measured cross-correlation for the growth rate of structure, fσ8(z), and the ratio DM(z)/DH(z) of the comoving angular diameter distance to the Hubble distance, in six redshift bins. For DM/DH, we are able to achieve a significantly higher precision than that obtained from analyses of the baryon acoustic oscillations and galaxy clustering in the same data sets. Our growth rate measurements are of lower precision but still comparable with galaxy clustering results. For both quantities, the results agree well with the expectations for a Λ cold dark matter model. Assuming a flat Universe, our results correspond to a measurement of the matter density parameter $\Omega _\mathrm{m}=0.337^{+0.026}_{-0.029}$. For more general models, the degeneracy directions obtained are consistent with and complementary to those from other cosmological probes. These results consolidate void–galaxy cross-correlation measurements as a pillar of modern observational cosmology.
Stability analysis of supermassive primordial stars: a new mass range for general relativistic instability supernovae
Authors: Nagele Chris , Umeda Hideyuki , Takahashi Koh , Yoshida Takashi , Sumiyoshi Kohsuke 
Published: September 2022

ABSTRACT
Observed supermassive black holes in the early Universe have several proposed formation channels in part because most of these channels are difficult to probe. One of the more promising channels, the direct collapse of a supermassive star has several possible probes including the explosion of a helium-core supermassive star triggered by a general relativistic instability. We develop a straightforward method for evaluating the general relativistic radial instability without simplifying assumptions and apply it to population III supermassive stars taken from a post Newtonian stellar evolution code. This method is more accurate than previous determinations and it finds that the instability occurs earlier in the evolutionary life of the star. Using the results of the stability analysis, we perform 1D general relativistic hydrodynamical simulations, and we find two general relativistic instability supernovae fuelled by alpha capture reactions as well as several lower mass pulsations, analogous to the puslational pair instability process. The mass range for the events ($2.6-3.0\times 10^4{\rm M}_\odot$) is lower than that had been suggested by previous works ($5.5\times 10^4{\rm M}_\odot$), because the instability occurs earlier in the star’s evolution. The explosion may be visible to among others JWST, while the discovery of the pulsations opens up additional possibilities for observation.
Radiomics as an emerging tool in the management of brain metastases
Authors: Nowakowski Alexander , Lahijanian Zubin , Panet-Raymond Valerie , Siegel Peter M , Petrecca Kevin , Maleki Farhad , Dankner Matthew 
Published: September 2022

AbstractBrain metastases (BM) are associated with significant morbidity and mortality in patients with advanced cancer. Despite significant advances in surgical, radiation, and systemic therapy in recent years, the median overall survival of patients with BM is less than 1 year. The acquisition of medical images, such as computed tomography (CT) and magnetic resonance imaging (MRI), is critical for the diagnosis and stratification of patients to appropriate treatments. Radiomic analyses have the potential to improve the standard of care for patients with BM by applying artificial intelligence (AI) with already acquired medical images to predict clinical outcomes and direct the personalized care of BM patients. Herein, we outline the existing literature applying radiomics for the clinical management of BM. This includes predicting patient response to radiotherapy and identifying radiation necrosis, performing virtual biopsies to predict tumor mutation status, and determining the cancer of origin in brain tumors identified via imaging. With further development, radiomics has the potential to aid in BM patient stratification while circumventing the need for invasive tissue sampling, particularly for patients not eligible for surgical resection.
An all-round AI-Chemist with a scientific mind
Authors: Zhu Qing , Zhang Fei , Huang Yan , Xiao Hengyu , Zhao LuYuan , Zhang XuChun , Song Tao , Tang XinSheng , Li Xiang , He Guo , Chong BaoChen , Zhou JunYi , Zhang YiHan , Zhang Baicheng , Cao JiaQi , Luo Man , Wang Song , Ye GuiLin , Zhang WanJun , Chen Xin , Cong Shuang , Zhou Donglai , Li Huirong , Li Jialei , Zou Gang , Shang WeiWei , Jiang Jun , Luo Yi 
Published: September 2022

Abstract
The realization of automated chemical experiments by robots unveiled the prelude to an artificial intelligence (AI) laboratory. Several AI-based systems or robots with specific chemical skills have been demonstrated, but conducting all-round scientific research remains challenging. Here, we present an all-round AI-Chemist equipped with scientific data intelligence that is capable of performing basic tasks generally required in chemical research. Based on a service platform, the AI-Chemist is able to automatically read the literatures from a cloud database and propose experimental plans accordingly. It can control a mobile robot in-house or online to automatically execute the complete experimental process on 14 workstations, including synthesis, characterization and performance tests. The experimental data can be simultaneously analysed by the computational brain of the AI-Chemist through machine learning and Bayesian optimization, allowing a new hypothesis for the next iteration to be proposed. The competence of the AI-Chemist has been scrutinized by three different chemical tasks. In the future, the more advanced all-round AI-Chemists equipped with scientific data intelligence may cause changes to the landscape of the chemical laboratory.
The Irish-Language Traditional Song Collection of Patrick Lynch, 1802–1803
Authors: Carolan Nicholas 
Published: September 2022

Abstract
This chapter describes song collecting trips made in Connacht and Ulster in 1802 and 1803 by Patrick Lynch (c.1750s–1838) of Loughinisland, Co. Down, for Edward Bunting and the promoters of the 1792 Belfast Harp Festival. The words of some four hundred Irish-language traditional pieces recorded by Lynch constitute the most important early collection of Irish song. He wrote them in longhand manuscript, mainly in Co. Mayo, and subsequently rewrote them in Gaelic script and translated them into English. His manuscripts are listed here and their history traced; they remain largely unpublished among those of Bunting in the Library of Queen’s University Belfast. In surviving letters and a journal, Lynch also preserved details of his source singers and of his collecting experiences and strategies. The social and political contexts of Lynch’s work are outlined, including his connections with the Irish-language scribal tradition and with Thomas Russell and the United Irishmen movement.
Root acid phosphatases and rhizobacteria synergistically enhance white lupin and rice phosphorus acquisition
Authors: Aslam Mehtab Muhammad , Pueyo José J , Pang Jiayin , Yang Jinyong , Chen Weiguo , Chen Hao , Waseem Muhammad , Li Ying , Zhang Jianhua , Xu Weifeng 
Published: September 2022

Abstract
The rhizosheath is a belowground area that acts as a communication hub at the root–soil interface to promote water and nutrient acquisition. Certain crops, such as white lupin (Lupinus albus), acquire large amounts of phosphorus (P), owing partially to exudation of acid phosphatases (APases). Plant growth-promoting rhizobacteria also increase soil P availability. However, potential synergistic effects of root APases and rhizosheath-associated microbiota on P acquisition require further research. In this study, we investigated the roles of root purple APases (PAPs) and plant growth-promoting rhizobacteria in rhizosheath formation and P acquisition under conditions of soil drying (SD) and P treatment (+P: soil with P fertilizer; –P: soil without fertilizer). We expressed purple acid phosphatase12 (LaPAP12) in white lupin and rice (Oryza sativa) plants and analyzed the rhizosheath-associated microbiome. Increased or heterologous LaPAP12 expression promoted APase activity and rhizosheath formation, resulting in increased P acquisition mainly under SD–P conditions. It also increased the abundance of members of the genus Bacillus in the rhizosheath-associated microbial communities of white lupin and rice. We isolated a phosphate-solubilizing, auxin-producing Bacillus megaterium strain from the rhizosheath of white lupin and used this to inoculate white lupin and rice plants. Inoculation promoted rhizosheath formation and P acquisition, especially in plants with increased LaPAP12 expression and under SD–P conditions, suggesting a functional role of the bacteria in alleviating P deficit stress via rhizosheath formation. Together, our results suggest a synergistic enhancing effect of LaPAP12 and plant growth-promoting rhizobacteria on rhizosheath formation and P acquisition under SD–P conditions.
Effects of High-Definition Transcranial Direct Current Stimulation Targeting the Anterior Cingulate Cortex on the Pain Thresholds: A Randomized Controlled Trial
Authors: Xiong Huan-Yu , Cao Yin-Quan , Du Shu-Hao , Yang Qi-Hao , He Si-Yi , Wang Xue-Qiang 
Published: September 2022

AbstractBackgroundThe majority of existing clinical studies used active transcranial direct current stimulation (tDCS) over superficial areas of the pain neuromatrix to regulate pain, with conflicting results. Few studies have investigated the effect of tDCS on pain thresholds by focusing on targets in deep parts of the pain neuromatrix.MethodsThis study applied a single session of high-definition tDCS (HD-tDCS) targeting the anterior cingulate cortex (ACC) and used a parallel and sham-controlled design to compare the antinociceptive effects in healthy individuals by assessing changes in pain thresholds. Sixty-six female individuals (mean age, 20.5 ± 2.4 years) were randomly allocated into the anodal, cathodal, or sham HD-tDCS groups. The primary outcome of the study was pain thresholds (pressure pain threshold, heat pain threshold, and cold pain threshold), which were evaluated before and after stimulation through the use of quantitative sensory tests.ResultsOnly cathodal HD-tDCS targeting the ACC significantly increased heat pain threshold (P &lt; 0.05) and pressure pain threshold (P &lt; 0.01) in healthy individuals compared with sham stimulation. Neither anodal nor cathodal HD-tDCS showed significant analgesic effects on cold pain threshold. Furthermore, no statistically significant difference was found in pain thresholds between anodal and sham HD-tDCS (P &gt; 0.38). Independent of HD-tDCS protocols, the positive and negative affective schedule scores were decreased immediately after stimulation compared with baseline.ConclusionsThe present study has found that cathodal HD-tDCS targeting the ACC provided a strong antinociceptive effect (increase in pain threshold), demonstrating a positive biological effect of HD-tDCS.
High-fidelity reprogramming into Leydig-like cells by CRISPR activation and paracrine factors
Authors: Li Zhaohui , Fan Yuxiao , Xie Cankun , Liu Jierong , Guan Xiaoju , Li Shijun , Huang Yadong , Zeng Rong , Chen Haolin , Su Zhijian 
Published: September 2022

Abstract
Androgen deficiency is a common medical conditions that affects males of all ages. Transplantation of testosterone-producing cells is a promising treatment for male hypogonadism. However, getting a cell source with the characteristics of Leydig cells (LCs) is still a challenge. Here, a high-efficiency reprogramming of skin-derived fibroblasts into functional Leydig-like cells (LLCs) based on epigenetic mechanism was described. By performing an integrated analysis of genome-wide DNA methylation and transcriptome profiling in LCs and fibroblasts, the potentially epigenetic-regulating steroidogenic genes and signaling pathways were identified. Then by using CRISPR/dCas9 activation system and signaling pathway regulators, the male- or female-derived fibroblasts were reprogrammed into LLCs with main LC-specific traits. Transcriptomic analysis further indicated that the correlation coefficients of global genes and transcription factors between LLCs and LCs were higher than 0.81 and 0.96, respectively. After transplantation in the testes of hypogonadal rodent models, LLCs increased serum testosterone concentration significantly. In type 2 diabetic rats model, LLCs which were transplanted in armpit, have the capability to restore the serum testosterone level and improve the hyperglycemia status. In conclusion, our approach enables skin-derived fibroblasts reprogramming into LLCs with high fidelity, providing a potential cell source for the therapeutics of male hypogonadism and metabolic-related comorbidities.
Close (Causally Connected) Cousins?
Authors: Dinesen Peter Thisted , Sønderskov Kim Mannemar , Sohlberg Jacob , Esaiasson Peter 
Published: September 2022

AbstractTrust in one’s fellow citizens and in politicians are both conducive to well-functioning government. Beyond their separate importance, it is a long-standing notion that generalized social trust and political trust are connected in a mutually reinforcing relationship that further undergirds democratic governance. While it is well established that social trust and political trust are robustly positively associated at the individual level, there is much less compelling evidence regarding the causal nature of this relationship. Previous analyses have been unable to adequately rule out confounding and correct for reverse causality. This paper tackles these challenges through data and a research design close to ideally suited for addressing the causal status of the relationship. Using a 20-wave individual-level panel survey from Sweden analyzed using a dynamic panel model, we find evidence for a relatively strong positive causal effect of political trust on social trust, but little evidence for the reverse relationship.
Relativistic correction of the Coulomb interaction in the local density approximation for energies and radii in doubly-magic nuclei
Authors: Naito Tomoya 
Published: September 2022

Abstract
Effects of the relativistic correction of the Coulomb interaction on doubly-magic nuclei are discussed with Skyrme Hartree–Fock calculations. The relativistic correction is treated by using the local density approximation. It is found that the correction to the total energy is about $2.4 \, \mathrm{MeV}$ for ${}^{208}_{}\mathrm{Pb}$, while the proton and neutron radii do not change significantly. This difference is larger than the difference of the Coulomb exchange (Fock) energy calculated with the local density (Hartree–Fock–Slater) approximation and that with the exact treatment and the neutron finite-size effect. Effects of the correction are also compared to the correction due to the vacuum polarization. It is shown that the two contributions to the total energy are comparable in light nuclei, but the latter dominates in heavy nuclei, while the contribution of the relativistic correction to the total energy is non-negligible compared to the target accuracy of the DFT calculation.
Board Reforms, Stock Liquidity, and Stock Market Development
Authors: Qiu Buhui , To Thomas Y 
Published: September 2022

Abstract
This paper studies the effect of board reforms on stock liquidity using data from 37 countries. We document that board reforms significantly increase stock liquidity: the effective spread on average decreases by 12.7% after a board reform. As information asymmetry is a key determinant of stock liquidity, we further find that board reforms decrease information asymmetry, and the treatment effect of board reforms on stock liquidity is stronger for firms with ex ante higher information asymmetry. Finally, board reforms facilitate healthy stock market development, with the effect being stronger for countries with lower aggregate stock market liquidity prior to reforms. (JEL G14, G15, G18)
Lower risk of gout in sodium glucose cotransporter 2 (SGLT2) inhibitors versus dipeptidyl peptidase-4 (DPP4) inhibitors in type-2 diabetes
Authors: Zhou Jiandong , Liu Xuejin , Chou Oscar Hou-In , Li Lifang , Lee Sharen , Wong Wing Tak , Zhang Qingpeng , Chang Carlin , Liu Tong , Tse Gary , Jing Fengshi , Cheung Bernard Man Yung 
Published: September 2022

AbstractObjectivesThe effects of sodium-glucose cotransporter 2 inhibitors (SGLT2I) vs dipeptidyl peptidase-4 inhibitors (DPP4I) on the risk of new-onset gout remains unknown. This study aims to compare the effects of SGLT2I against DPP4I on gout risks.MethodsThis was a retrospective population-based cohort study of patients with type-2 diabetes mellitus treated with SGLT2I or DPP4I between 1 January 2015 and 31 December 2020 in Hong Kong. The study outcomes are new-onset gout and all-cause mortality. Propensity score matching (1:1 ratio) between SGLT2I and DPP4I was performed. Univariable and multivariable Cox regression models were conducted. Competing risks models and multiple approaches based on the propensity score were applied.ResultsThis study included 43 201 patients [median age: 63.23 years old (Interquartile range, IQR): 55.21–71.95, 53.74% males; SGLT2I group: n = 16 144; DPP4I group: n = 27 057] with a median follow-up of 5.59 years (IQR: 5.27–5.81 years) since initial drug exposure. The incidence rate of developing gout [Incidence rate (IR): 2.5; 95% CI: 2.2, 2.9] among SGLT2I users was significantly lower than DPP4I users (IR: 5.2; 95% CI: 4.8, 5.8). SGLT2I was associated with 51% lower risks of gout (HR: 0.49; 95% CI: 0.42, 0.58; P-value &lt; 0.0001) and 51% lower risks of all-cause mortality (HR: 0.49; 95% CI: 0.42, 0.58; P-value &lt; 0.0001) after adjusting for significant demographics, past comorbidities, medications and laboratory results. The results remained consistent on competing risk and other propensity score approaches.ConclusionsSGLT2I use was associated with lower risks of new gout diagnosis compared with DPP4I use.
Relationship between the prevalence of subclinical tenosynovitis and treatment in patients with RA in clinical remission: STARTER study
Authors: Parisi Simone , Zanetti Anna , Carrara Greta , Scirè Carlo Alberto , Iagnocco Annamaria , Filippou Georgios ,   the STARTER Investigators, Batticciotto Alberto , Floris Alberto , Bortoluzzi Alessandra , Gabba Alessandra , Gattamelata Angelica , Adinolfi Antonella , Raffeiner Bernd , Venditti Carlo , Mastaglio Claudio , Scioscia Crescenzio , Rossi Daniela , Bellis Emanuela , Luccioli Filippo , Cavatorta Francesco Paolo , Ceccarelli Fulvia , Sakellariou Garifallia , Cagnotto Giovanni , Farina Ilaria , Menza Luana , Idolazzi Luca , Canzoni Marco , Massarotti Marco , Focherini Maria Cristina , Caprioli Marta , Gutierrez Marwin , Draghessi Antonella , Piga Matteo , Muratore Maurizio , De Lucia Orazio , Rossini Paola , Macchioni Pierluigi , Ramonda Roberta , Rossi Daniela , Rossi Silvia , Di Sabatino Valentina , Picerno Valentina 
Published: September 2022

AbstractObjectiveThis study is a sub-analysis from the patient cohort of the STARTER (Sonographic Tenosynovitis Assessment in RheumaToid arthritis patiEnts in Remission) study. The aim was to evaluate differences in ultrasound-detected joint and/or tendon involvement between patients receiving therapies based on a combination of conventional synthetic DMARDs (csDMARDs) and biologic DMARDs (bDMARDs) and those who were treated with either csDMARDs or bDMARDs in monotherapy.Material and methodsFour hundred and twenty-seven consecutive patients with a diagnosis of RA were recruited between October 2013 and June 2014. They were divided into three subgroups based on their therapy at baseline: patients with bDMARD in monotherapy, patients with csDMARD in monotherapy and patients in combination therapy (csDMARD + bDMARD). At baseline, 6 months and 12 months, a clinical examination (28 joint count) and an ultrasound evaluation were performed in each patient. A score of grey-scale (GS) and power Doppler (PD) synovitis and tenosynovitis was calculated based on the OMERACT scoring systems.ResultsTwo hundred and fifty-six patients completed the observation period: 48 patients from the bDMARD group (18.75%), 152 patients from the csDMARD group (59.38%) and 56 patients from csDMARD + bDMARD group (21.88%). The analysis showed that GS tenosynovitis and PD tenosynovitis are better controlled in combination therapy than they are with csDMARD alone (P = 0.025 and P = 0.047, respectively); for PD synovitis, there was a better response in those who were treated with the combination therapy when compared with the patients receiving csDMARD (P = 0.01) or bDMARD (P = 0.02) alone.ConclusionsThe analysis showed a lower prevalence of subclinical inflammatory manifestations detected with ultrasound imaging in those patients treated with the combination therapy than in those in monotherapy.
Multimodal Magnetic Resonance Imaging Depicts Widespread and Subregion Specific Anomalies in the Thalamus of Early-Psychosis and Chronic Schizophrenia Patients
Authors: Alemán-Gómez Yasser , Baumgartner Thomas , Klauser Paul , Cleusix Martine , Jenni Raoul , Hagmann Patric , Conus Philippe , Do Kim Q , Bach Cuadra Meritxell , Baumann Philipp S , Steullet Pascal 
Published: September 2022

Abstract

Background and Hypothesis
Although the thalamus has a central role in schizophrenia pathophysiology, contributing to sensory, cognitive, and sleep alterations, the nature and dynamics of the alterations occurring within this structure remain largely elusive. Using a multimodal magnetic resonance imaging (MRI) approach, we examined whether anomalies: (1) differ across thalamic subregions/nuclei, (2) are already present in the early phase of psychosis (EP), and (3) worsen in chronic schizophrenia (SCHZ).

Study Design
T1-weighted and diffusion-weighted images were analyzed to estimate gray matter concentration (GMC) and microstructural parameters obtained from the spherical mean technique (intra-neurite volume fraction [VFINTRA)], intra-neurite diffusivity [DIFFINTRA], extra-neurite mean diffusivity [MDEXTRA], extra-neurite transversal diffusivity [TDEXTRA]) within 7 thalamic subregions.

Results
Compared to age-matched controls, the thalamus of EP patients displays previously unreported widespread microstructural alterations (VFINTRA decrease, TDEXTRA increase) that are associated with similar alterations in the whole brain white matter, suggesting altered integrity of white matter fiber tracts in the thalamus. In both patient groups, we also observed more localized and heterogenous changes (either GMC decrease, MDEXTRA increase, or DIFFINTRA decrease) in mediodorsal, posterior, and ventral anterior parts of the thalamus in both patient groups, suggesting that the nature of the alterations varies across subregions. GMC and DIFFINTRA in the whole thalamus correlate with global functioning, while DIFFINTRA in the subregion encompassing the medial pulvinar is significantly associated with negative symptoms in SCHZ.

Conclusion
Our data reveals both widespread and more localized thalamic anomalies that are already present in the early phase of psychosis.