bluuebunny/crossref_metadata_2025_split huggingface dataset:
PENATAAN DAN PENANGANAN PARKIR PADA BADAN JALAN SEPANJANG RUAS JALAN CIMANUK KABUPATEN GARUT
Authors: Jurista Angga , Farida Ida 
Published: June 2022

Dalam upaya peningkatan kinerja lalu lintas di Kabupaten Garut, khususnya di Jalan Cimanuk, dimana di jalan ini adalah salah satu pusat perdagangan di Kabupaten Garut sehingga seringkali terjadi kemacetan lalu lintas dan kesemrawutan parkir kendaraan. Maka dari itu perlu pengkajian kembali dengan sistem lalu lintas dan perparkiran di Jalan tersebut. Penelitian ini bertujuan untuk penataan parkir serta mengetahui kebutuhan ruang parkir untuk menampung volume kendaraan yang parkir disepanjang ruas Jalan Cimanuk. Data yang diperlukan meliputi data primer dan data sekunder. Data primer diperoleh dengan pengamatan langsung dilapangan, meliputi: data volume lalu lintas dan volume kendaraan parkir,Â metode pengumpulan data untuk mengetahui jumlah volume kendaraan parkir dengan cara pencatatan langsung nomor polisi kendaraan yang parkir di badan jalan sepanjang ruas Jalan Cimanuk yang di bagi kedalam dua Blok pengamatan yaitu Blok-1 dari batas Bunderan Simpang lima sampai dengan bunderan Leuwidaun dengan panjang jalan yaitu Â±2,46 Km, dan Blok-2 dari Bunderan Leuwidaun sampai dengan Perempatan Maktal dengan panjang Jalan Â±1,79 Km. Survei dilakukan pada 3 interval waktu, jam 08.00-09.00, 12.00-13.00, 14.00-17.00 dalam jangka waktu 3 hari yaitu, Senin, Kamis dan Sabtu. Hasil kajian menjelaskan bahwa, selama penelitian total volume parkir kendaraan di badan jalan sepanjang Jalan Cimanuk menunjukan puncak kendaraan parkir terjadi di hari Sabtu pada waktu sore hari yaitu antara pukul 16:00 â€“ 17:00 WIB, dengan total kendaraan parkir berjumlah 424 kendaraan. Volume puncak lalu lintasÂ tertinggi yaitu pada hari Senin dengan interval waktu pada sore hari yaitu pukul 16:15-16:30 WIB dengan jumlah kendaraan 6066/ 15 Menit atau 3089,65 SMP/15 Menit. Berdasarkan survei dilapangan untuk kriteria yang layak dijadikan lahan parkir di badan Jalan sepanjang Jalan Cimanuk yaitu 8 titik lokasi. Adapun alternatif pola parkir yang dipakai adalah pola parkir paralel. Sedangkan Lokasi yang dapat di jadikan alternatif area parkir diluar badan jalan pada kawasan Jalan Cimanuk adalah pada ex- Gedung Pelayanan Pajak. Kebutuhan ruang parkir kendaraan ringan untuk kondisi saat ini sebanyak 228 petak, sedangkan untuk sepeda motor sebanyak 246 petak. Dan dari analisa secara ekonomi untuk pendapatan dalam 1 bulan/30 hari untuk kendaraan ringan adalah Rp.14.340.000/bulan, dan untuk sepeda motor adalah Rp. 14.670.000/bulan.
PERANCANGAN SISTEM INFORMASI AKTIVA TETAP DENGAN MENGGUNAKAN FRAMEWORK SCRUM
Authors: Hardani Sri , Leliyanah Leliyanah 
Published: June 2022

Aktiva tetap merupakan salah satu faktor pendukung dalam kegiatan operasional perusahaan dan bersifat tetap. Dalam perolehan aktiva tetap membutuhkan biaya yang besar dan diharapkan dapat dipergunakan dalam jangka waktu yang lama. Sebagai modal yang digunakan dalam kegiatan operasional perusahaan, maka nilai aktiva tetap akan mengalami penurunan. Dengan menurunnya nilai aktiva tetep seiring penggunaannya dalam operasional perusahaan, maka perlu dihitung biaya penyusutan aktiva tetap. Sebuah perusahaan yang merupakan perusahaan manufaktur yang dalam menjalankan usahanya membutuhkan berbagai macam aktiva tetap, seperti mesin-mesin, kendaraan, peralatan kantor, dan lain-lain. Banyaknya jumlah aktiva tetap dan proses pencatatan yang masih menggunakan Microsoft Excel tentunya memberikan kesulitan tersendiri bagi petugas yang melakukan pencatatan dan menginventarisir aktiva tetap. Kesalahan dalam menghitung biaya penyusutan, kesalahan dalam menginput nominal, kesalahan dalam menghitung nilai buku aktiva tetap, lupa menginput biaya penyusutan di tanggal yang seharusnya, merupakan beberapa contoh permasalahan yang sering terjadi. Dengan adanya sistem informasi aktiva tetap, akan dapat mengurangi beban kerja paetugas, sekaligus dapat memberikan informasi yang lebih akurat mengenai data aktiva tetap. Pengembangan aplikasi dengan metode scrum diharapkan dapat menghasilkan aplikasi yang lebih sesuai dengan kebutuhan pengguna. Karena dengan metode scrum, segala bentuk perubahan kebutuhan pengguna dapat dengan mudah disesuaikan tanpa harus menunggu aplikasi selesai secara keseluruhan.
PENINGKATAN KUALITAS CITRA BAWAH AIR BERBASIS ALGORITMA FUSION DENGAN KESEIMBANGAN WARNA, OPTIMALISASI KONTRAS, DAN PEREGANGAN HISTOGRAM
Authors: Suharyanto Suharyanto , Frieyadie Frieyadie , Kuryanti Sandra Jamu 
Published: June 2022

Para peneliti saat ini memberikan perhatian yang cukup besar terhadap obyek citra bawah air, kebutuhan akan aplikasi pengamatan citra bawah air memiliki peran yang sangat penting dalam mengidentifikasi objek, pemantauan kehidupan spesies, deteksi kebocoran pipa minyak atau gas, pemantauan polusi, dan sebagainya. Degradasi citra bawah air merupakan fenomena atmosfer yang merupakan hasil dari hamburan dan penyerapan cahaya. Kami menggunakan satu gambar terdistorsi untuk mendapatkan kontras yang ditingkatkan dan versi koreksi warna dari gambar aslinya. Selanjutnya menghilangkan distorsi dan meningkatkan visibilitas objek dalam gambar dengan menerapkan peta bobot, hal ini dapat dicapai dengan menerapkan penyeimbangan warna putih, kemudian penajaman menggunakan gaussian filtering dilakukan untuk, meningkatkan tampilan visual. pada setiap input yang di proses. Langkah terakhir dilakukan menaikan nilai kontras dengan koreksi peregangan kontras yang dibatasi utuk meningkatkan warna keabuan dan uuntuk menhjilangkan efek noise yang berlebihan pada latar belakang obyek gambar. Hasil penelitian evaluasi menggunakan fitur Root Mean Squared Error (RMSE), dan Peak Signal-to-Noise Ratio (PSNR) dan kami bandingkan dengan metode CLAHE. Hasil evaluasi menunjukkan peningkatan PNSR yang signifikan kualitas citra yg di perbaiki menggunakan algoritma kombinasi dibanding dengan menggunakan metode CLAHE sebagaimana yang kami paparkan dalam bagian hasil penelitian.
Bienestar e integración en América Latina: el papel de la IED
Authors: Hernández Mota José Luis , Marín Medrano Iván Abdel 
Published: June 2022

Se analiza la relación entre la IED, la integración comercial, la actividad económica y el bienestar individual de economías representativas de América Latina: Brasil, Chile, Colombia y México. Se utiliza un modelo empírico con datos panel bajo la hipótesis de que la IED puede generar incrementos productivos y el consiguiente beneficio de la integración a nivel del bienestar individual. Aunque se aporta evidencia para consolidar y fortalecer los procesos de integración llevados a cabo, dada la heterogeneidad económica, los resultados obtenidos también permiten mostrar la importancia de las medidas de política económica en una economía receptora de IED.
Adriamycin-Induced Nephropathy is Robust in N and Modest in J Substrain of C57BL/6
Authors: Bryant Claire , Cianciolo Rachel , Govindarajan Rajgopal , Agrawal Shipra 
Published: June 2022

Adriamycin (ADR)-induced nephropathy remains the leading model to study human primary focal segmental glomerulosclerosis (FSGS), a common pathway for podocyte damage and glomerular loss of function that leads to chronic kidney disease. However, the use of this model for reverse genetics is limited by historical categorization of C57BL/6 mice as an ADR-resistant strain, which is also the most common genetically modified strain. Additionally, conflicting reports exist utilizing C57BL/6 for ADR-nephrosis due to lack of understanding of substrain differences (J/N) and variability in ADR dosage, timing, and frequency to induce damage. We have undertaken a systematic approach to elucidate the specifics of ADR-nephrosis in C57BL/6 N and J substrains. We induced nephropathy with 2 doses of ADR, and measured albuminuria for 6 weeks and performed histological evaluations. Our findings revealed induction of robust and modest proteinuria in N and J substrains, respectively. The serum creatinine levels were elevated in N, but not J substrain. Both the substrains showed reduction in body weight with N greater than J, although mortality remained at 0% in both substrains. Histological analysis showed worse renal lesions in the N than the J substrain. Podocyte markers synaptopodin, nephrin, podocin, and WT1 were reduced to a greater extent in the N than the J substrain. In summary, we provide the nephrology community with a reproducible mouse model for FSGS, in a strain otherwise assumed to be ADR-resistant and highlight the differences between J and N substrains. This enables future studies, especially concerning genetically manipulated animal models in C57BL/6.
Risk and Protective Factors for Sudden Cardiac Death: An Umbrella Review of Meta-Analyses
Authors: Tsartsalis Dimitrios , Korela Dafni , Karlsson Lars O. , Foukarakis Emmanouil , Svensson Anneli , Anastasakis Aris , Venetsanos Dimitrios , Aggeli Constantina , Tsioufis Costas , Braunschweig Frieder , Dragioti Elena , Charitakis Emmanouil 
Published: June 2022

BackgroundSudden cardiac death (SCD) is a global public health issue, accounting for 10–20% of deaths in industrialized countries. Identification of modifiable risk factors may reduce SCD incidence.MethodsThis umbrella review systematically evaluates published meta-analyses of observational and randomized controlled trials (RCT) for the association of modifiable risk and protective factors of SCD.ResultsFifty-five meta-analyses were included in the final analysis, of which 31 analyzed observational studies and 24 analyzed RCTs. Five associations of meta-analyses of observational studies presented convincing evidence, including three risk factors [diabetes mellitus (DM), smoking, and early repolarization pattern (ERP)] and two protective factors [implanted cardiac defibrillator (ICD) and physical activity]. Meta-analyses of RCTs identified five protective factors with a high level of evidence: ICDs, mineralocorticoid receptor antagonist (MRA), beta-blockers, and sodium-glucose cotransporter-2 (SGLT-2) inhibitors in patients with HF. On the contrary, other established, significant protective agents [i.e., amiodarone and statins along with angiotensin-converting enzyme (ACE) inhibitors in heart failure (HF)], did not show credibility. Likewise, risk factors as left ventricular ejection fraction in HF, and left ventricular hypertrophy, non-sustain ventricular tachycardia, history of syncope or aborted SCD in pediatric patients with hypertrophic cardiomyopathy, presented weak or no evidence.ConclusionsLifestyle risk factors (physical activity, smoking), comorbidities like DM, and electrocardiographic features like ERP constitute modifiable risk factors of SCD. Alternatively, the use of MRA, beta-blockers, SGLT-2 inhibitors, and ICD in patients with HF are credible protective factors. Further investigation targeted in specific populations will be important for reducing the burden of SCD.Systematic Review Registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42020216363, PROSPERO CRD42020216363.
The Clinical Trial Outcomes of Med-Zenith PT-Valve in the Treatment of Patients With Severe Pulmonary Regurgitation
Authors: Shang Xiaoke , Dong Nianguo , Zhang Changdong , Wang Yanggan 
Published: June 2022

ObjectiveNearly 2/3 of patients with dilated right ventricular outflow tract (RVOT) were excluded from pulmonary valves transplantation due to the lack of size-matched valves. Here, we explored the safety and efficacy of the Med-Zenith PT-Valve for the treatment of patients with severe pulmonary regurgitation.Methods22 Patients with severe PR (grade 3+,4+) were enrolled based on the anatomical features of native RVOT and the valve design. The immediate, 3-months and 1-year post-procedural follow-up data were analyzed.ResultsThe baseline mean systolic diameters in the distal main pulmonary artery (MPA), MPA sinus junction, MPA sinus, pulmonary annulus, RVOT aneurysm and muscular outlet measured with computed tomography were 33.6 ± 6.1, 34.0 ± 5.8, 37.9 ± 6.0, 32.4 ± 7.3, 41.9 ± 9.3, and 34.4 ± 8.0 mm, respectively. The PT-Valve landing zone was set within these levels. Successful valve implantations were achieved in all patients without noticeable device malposition, coronary artery compression, pulmonary branch obstruction or paravalvular leak during follow-ups. Post-procedural pulmonary artery diastolic pressure increased from 5.8 ± 3.1 to 11.3 ± 2.5 mmHg. In the 3-month and 1-year follow-up, the right ventricular end diastolic volume index reduced from the baseline 181.6 ± 29.0 to 143.7 ± 29.7 ml/m2 and 123.4 ± 31.2 ml/m2, and the trans-pulmonary valve gradient decreased from 25.6 ± 22.2 to 10.64 ± 3.54 mmHg and 11.16 ± 3.0 mmHg, respectively. The 6-min walk distance increased from 416.6 ± 97.9 to 455.9 ± 64.6 m and 467.8 ± 61.2 m, respectively.ConclusionThis clinical trial revealed favorable outcomes for the safety, efficacy and feasibility of the Med-Zenith PT-Valve in the treatment of severe PR with significantly enlarged RVOT.
Admission Lysophosphatidic Acid Is Related to Impaired Kidney Function in Acute Aortic Dissection: 2-Year Retrospective Follow-Up Study
Authors: Pan Xiaogao , Yang Guifang , Ding Ning , Peng Wen , Guo Tuo , Zeng Mengping , Chai Xiangping 
Published: June 2022

BackgroundDelayed treatment of acute aortic dissection (AAD)-related acute kidney injury (AKI) significantly increases the burden of chronic kidney disease (CKD) and mortality. Lysophosphatidic acid (LPA) is a shared mediator of kidney disease and AAD. Here, we evaluated the relationship between LPA and kidney injury in AAD patients.MethodsWe measured the plasma concentration of LPA in a cohort of 80 patients with AAD. Least Absolute Shrinkage and Selection Operator (LASSO) regression and Logistic regression were used to evaluate the effect and interaction of LPA on AKI. Additive generalized model and penalized spline method were used to describe the non-linear association. Multivariable analyses with the Cox proportional-hazards model were used for subgroup analysis and interaction in LPA and subsequent CKD.ResultsThe participant’s average age was 54.27 ± 11.00 years, 68.75% of them were males, and the incidence of AKI was 43.75%. Patients with AKI had higher levels of LPA on admission, and the more significant the increase, the higher the risk of AKI. There was a non-linear positive correlation between admission LPA and AKI, and the premeditated inflection point was 346.33 (μg/dL) through two-piecewise linear regression and recursive algorithm. Subgroup analysis identified a stronger association between admission LPA and AKI in the elder, female and medically treated patients. The incidence of CKD was 22.67% in the 2-year follow-up. Patients with subsequent CKD had higher LPA levels on admission in the follow-up cohort, and a similar interaction trend was also observed through Cox proportional—hazards model.ConclusionAdmission LPA levels show a non-linear positive correlation with AKI and increase the risk of subsequent CKD, which is more pronounced in elderly, female, and medically treated patients.
GaSbBi Metal Semiconductor Metal Detectors for Mid-Infrared Sensing
Authors: Cao Zhongming , Hulme Sorcha , Veal Tim D. , Ashwin Mark J. , Sandall Ian 
Published: June 2022

The viability of incorporating Bi and N into GaSb layers to realise photodetectors operating in the mid-infrared has been investigated. The effects of Bi and N on the cut-off wavelength of GaSb metal-semiconductor-metal photodetectors has been evaluated. The spectral responsivity measurements indicate a clear wavelength extension, to 1950 nm (Bi, 2.9%), 1990 nm (Bi, 3.8%), 2080 nm (Bi, 4.5%) and 2190 nm (N, 1.5%) from a reference GaSb device at 1720 nm, with only a relatively modest reduction in the external quantum efficiency (EQE). Comparisons of spectral response characteristics indicate that Bi incorporation reduces the carrier extraction and the impact of this on future device design is considered.
A Clinical Predictive Model of Central Lymph Node Metastases in Papillary Thyroid Carcinoma
Authors: Wang Zipeng , Chang Qungang , Zhang Hanyin , Du Gongbo , Li Shuo , Liu Yihao , Sun Hanlin , Yin Detao 
Published: June 2022

BackgroundThyroid carcinoma is one of the most common endocrine tumors, and papillary thyroid carcinoma (PTC) is the most common pathological type. Current studies have reported that PTC has a strong propensity for central lymph node metastases (CLNMs). Whether to prophylactically dissect the central lymph nodes in PTC remains controversial. This study aimed to explore the risk factors and develop a predictive model of CLNM in PTC.MethodsA total of 2,554 patients were enrolled in this study. The basic information, laboratory examination, characteristics of cervical ultrasound, genetic test, and pathological diagnosis were collected. The collected data were analyzed by univariate logistic analysis and multivariate logistic analysis. The risk factors were evaluated, and the predictive model was constructed of CLNM.ResultsThe multivariate logistic analysis showed that Age (p &lt; 0.001), Gender (p &lt; 0.001), Multifocality (p &lt; 0.001), BRAF (p = 0.027), and Tumor size (p &lt; 0.001) were associated with CLNM. The receiver operating characteristic curve (ROC curve) showed high efficiency with an area under the ROC (AUC) of 0.781 in the training group. The calibration curve and the calibration of the model were evaluated. The decision curve analysis (DCA) for the nomogram showed that the nomogram can provide benefits in this study.ConclusionThe predictive model of CLNM constructed and visualized based on the evaluated risk factors was confirmed to be a practical and convenient tool for clinicians to predict the CLNM in PTC.
The Effect of HER2 Status on Metaplastic Breast Cancer A Propensity Score-Matched Analysis
Authors: Hu Jin , Zhang Yanting , Dong Fang , Shen Jian , Chen Hengyu , Li Lei , Huang Tao 
Published: June 2022

BackgroundThe role of human epidermal growth factor receptor 2 (HER2) in metaplastic breast cancer (MBC) patients remains unclear. The present study aimed to evaluate the effect of HER2 status on MBC patients by propensity-score matching (PSM).MethodsThe SEER data from 2010 to 2016 were extracted. The breast cancer-specific survival (BCSS) of MBC patients, diagnosed from 2001 to 2016, was compared using Kaplan–Meier analysis. The multivariate Cox proportional model between groups was performed. PSM was used to make 1:1 case-control matching.ResultsWe included 1887 patients with a median follow-up time of 28 months (range 1-83 months). 1749 (92.7%) and 138 (7.3%) patients presented in the HER2-negative group and HER2-positive group. 833 (44.1%) patients received post-mastectomy radiotherapy (PMRT). The HER2-positive group had younger patients, lower tumor grades, and more advanced tumor stages. The prognoses were related to age of diagnosis, race/ethnicity, TNM stage, and PMRT in multivariate Cox analysis. ER status and HER2 status had no impact on BCSS. In the Kaplan-Meier analysis, PMRT was associated with a better prognosis. Importantly, patients with HER2-negative status can benefit from PMRT, but not those with HER2-positive status. After PSM, on multivariate Cox analysis, the prognosis was related to HER2 status and PMRT. In the Kaplan-Meier analysis, PMRT was related to a better prognosis for HER2-negative patients.ConclusionsOur findings supported that PMRT and HER2-positive status were associated with a better prognosis after PSM. However, HER2-negative, but not HER2-positive patients could benefit from PMRT.
Risk Factors for Neck Nodal Metastasis in Papillary Thyroid Cancer With BRAF V600E Mutation
Authors: Han Ying , Hou Ling , Zhao Bowen , Gao Li , Li Shiyan 
Published: June 2022

BackgroundThe BRAF V600E mutation is the most common genetic variant in papillary thyroid cancer (PTC), but the relationship between the BRAF V600E mutation in PTC and cervical lymph node metastasis (LNM) remains controversial.ObjectiveTo estimate risk factors for neck nodal metastasis in PTC with BRAF V600E mutation.PatientsA total of 292 patients diagnosed with BRAF V600E mutation related PTC were admitted.DesignIn this retrospective study, data from 292 patients, including clinical, molecular, and ultrasonic characteristics, were analyzed. Univariate and multivariate logistic regression analyses were applied to identify risk factors for LNM in PTC with the BRAF V600E mutation.ResultsIn the univariate analysis of all PTC patients with the BRAF V600E mutation, the LNM was found to be significantly associated with age (P = 0.010), size (P = 0.000), bilaterality (P = 0.000), multifocality (P = 0.002), LNM in ultrasound (US) (P = 0.000), and capsular invasion (P = 0.010). In ultrasonic image characteristics, margin (P = 0.036), shape (P = 0.046), and microcalcification (P = 0.002) were significantly associated with LNM. In multivariate analysis, LNM in PTCs with BRAF V600E mutation was significantly associated with age ≤ 45 years (OR = 1.869, P = 0.020, 95% CI = 1.106 - 3.158), size ≥ 1cm (OR = 3.131, P = 0.001, 95% CI = 1.578 - 6.212), LNM in US (OR = 6.962, P = 0.000, 95% CI = 2.924 - 16.572), bilaterality (OR = 1.626, P = 0.007, 95% CI = 1.142 - 2.314), ill-defined margins in US (OR = 1.980, P = 0.033, 95% CI = 1.057 - 3.709), and microcalcification in US (OR = 2.786, P = 0.002, 95% CI = 1.464 - 5.303).ConclusionThis study revealed that several significant risk factors for LNM in PTCs with the BRAF V600E mutation included: age ≤ 45 years, size ≥ 1cm, LNM in US, bilaterality, ill-defined margins in US, and microcalcification in US.
An Endometrial Thickness < 8 mm Was Associated With a Significantly Increased Risk of EP After Freeze-Thaw Transfer: An Analysis of 5,960 Pregnancy Cycles
Authors: Zhao Ying , Liu Dong’e , Liu Nenghui , Li Yumei , Yao Zhongyuan , Tian Fen , Xu Aizhuang , Li Yanping 
Published: June 2022

IntroductionEndometrium characteristics that are most likely to induce ectopic pregnancy were investigated on the basis of the data of 5,960 pregnant freeze-thaw cycles.MethodsA total of 5,960 pregnancy cycles after freeze-thaw embryos transfer were included, with the number of intrauterine and ectopic pregnancies being 5,777 and 183, respectively. Ectopic pregnancy was the primary outcome. Endometrial thickness was the main measured variable. The risk factors of ectopic pregnancy were eventually determined based on univariate analysis and subsequent multiple-stepwise logistic regression analysis.Results1. After adjusting for confounders, endometrial thickness could independently predict ectopic pregnancy. The adjusted odd ratios for women with endometrial thickness in the ranges of &lt; 8 mm, 8–9.9 mm, and 10–11.9 mm were 3.270 [95% confidence interval (CI), 1.113–9.605, P = 0.031], 2.758 (95% CI, 0.987–7.707, P = 0.053), and 1.456 (95% CI, 0.502–4.225, P = 0.489), respectively, when compared with those having an endometrial thickness of 12–13.9 mm. 2. Endometrial type and preparation protocol were however not identified as risk factors for ectopic pregnancy.Discussion1. After freeze-thaw embryo transfer, risks of ectopic pregnancy were significantly higher when the endometrial thickness was &lt; 8 mm. 2. A thin endometrial thickness could be linked with abnormal endometrial peristaltic waves or abnormal endometrial receptivity. 3. Adequate attention should therefore be paid to patients with a thin endometrial thickness to prevent EP or to achieve early diagnosis during the peri-transplantation period.