bluuebunny/crossref_metadata_2025_split huggingface dataset:
Novel dental anaesthetic and associated devices: a scoping review protocol
Authors: Min Kyung Hyuk , Morse Zac 
Published: September 2022

<p><strong>Background: </strong>In oral health, local anaesthesia is crucial for managing pain and discomfort. Typically, anaesthesia is administered by injecting an anaesthetic solution using a needle and syringe. However, new technologies have been created to aid oral health therapists in reducing pain and discomfort during local anaesthesia administration. The purpose of this study is to analyse and investigate alternate local anaesthetic delivery systems, such as current equipment, technologies, and associated devices that help reduce injection discomfort. In addition, information gaps and limitations of existing studies will be highlighted to guide future studies. The protocol for scoping available evidence, mapping key concepts, and identifying gaps for future research is detailed in this manuscript.<strong></strong></p><p><strong>Methods:</strong> The Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews (PRISMA-ScR) and Joanna Briggs Institute (JBI) Manual for Evidence Synthesis guidelines were used to create this protocol. Six electronic databases such as MEDLINE, CINAHL, AMED, Dentistry and Oral Science Source, and Scopus, and two other search engines, Google and Google Scholar, will be searched for all relevant primary and secondary studies, grey literature, and other sources relating to new technologies have been developed to assist dentists in providing reduced pain and discomfort when administering local anaesthesia. Two reviewers will independently evaluate the sources retrieved using the eligibility criteria defined by the Population Concept, and Context (PCC) framework. To track the number of identified, included, and excluded sources, a PRISMA-ScR flowchart will be used. A data extraction table will display the extracted data and variables. The synthesised results will be accompanied by narrative explanations.</p><p><strong>Conclusions: </strong>The findings of this review will be summarised to aid in identifying limitations in existing research and provide guidance and recommendations for future research for health professionals.</p>
Hope and culture: Relationships and implications for research, clinical and organizational practices
Authors: Oyarzo Felipe , Hellman Chan , Williamson Raymond 
Published: September 2022

Hope and culture are currently two relevant concepts of interest across multiple fields such as psychology, anthropology, sociology, social work, government, education, and business. Both theories are significant for the facilitation of individual and social well-being, but there is limited knowledge available in the literature regarding how these two concepts interact and position with respect to each other, and about how they can be applied collectively to research, clinical, family and organizational practices. The purpose of this study is to comprehend from a conceptual perspective the relationships that exist between hope and culture and their implications for research and professional practices.

Keywords: hope, culture, empathy, resilience, research, therapy, organizations, family, clinical practice, counseling, cultural awareness, cultural improvement, cultural humility, smart culture.
STRATEGI MARKETING REVOLUTION UNTUK MENINGKATKAN PENJUALAN PASCA PANDEMI COVID-19
Authors: Yuliati Yuliati 
Published: September 2022

The purpose of the study is to find out more deeply the marketing revolution as a "weapon" for culinary actors in Malang that is able to boost sales after the covid 19 pandemic. Facing a pandemic situation throughout Indonesia, business actors in Malang City can not escape from collapse. The effort to be able to increase income, raises the thought of the importance of "weapons" to get out of this problem by applying the theory of the marketing revolution. This research was conducted by prioritizing the role of the researcher during the research process with qualitative methods, the research subject was Markeso, the seller of morning soup. Direct primary data collection techniques. The data instruments are interview sheets, field notes and documentation. Data analysis by examining all available data from various sources, namely direct interviews, observations that have been written in field notes, personal documents, official documents, pictures, and photos. The results of the study prove that Soto Markeso has applied the principle of marketing revolution as a sales strategy, so that it has succeeded in increasing the number of loyal customers who are growing. The quality of taste is maintained for its deliciousness, cleanliness, and excellent service. In addition, market expansion is carried out by selling online and fulfilling orders for hotels, offices, and weddings to increase sales.

Abstrak
Tujuan penelitian untuk mengetahui secara lebih mendalam marketing revolution sebagai “senjata” pelaku kuliner di Malang yang mampu mendongkrak peningkatkan penjualan pasca pandemi covid 19. Menghadapi situasi pendemi di seluruh Indonesia tidak luput pelaku usaha di Kota Malang bisa terbebas dari keruntuhan. Usaha kembali untuk mampu meningkatkan pendapatan, menimbulkan pemikiran pentingnya “senjata” untuk keluar dari masalah ini dengan menerapkan teori marketing revolution. Penelitian ini dilakukan dengan mengedepankan peran peneliti selama proses penelitian dengan metode kualitatif, subjek penelitian Markeso penjual soto pagi. Teknik pengambilan data primer secara langsung. Instrumen data berupa lembar wawancara, lembar catatan lapangan dan dokumentasi. Analisis data dengan menelaah seluruh data yang tersedia dari berbagai sumber, yaitu wawancara langsung, pengamatan yang sudah dituliskan dalam catatan lapangan, dokumen pribadi, dokumen resmi, gambar, dan foto. Hasil penelitian membuktikan bahwa pada Soto Markeso telah menerapkan prinsip marketing revolution sebagai strategi penjualan, sehingga berhasil meningkatkan jumlah pelanggan setia yang semakin bertambah. Kualitas rasa dipertahankan kelezatannya, kebersihan, dan pelayanan prima. Selain itu, perluasan pasar dilakukan dengan penjualan online serta memenuhi pesanan untuk hotel, kantor, dan acara pernikahan untuk meningkatkan penjualan.
ANALISIS SWOT : Faktor Internal dan Eksternal dalam Upaya Meningkatkan Kualitas Pendidikan di MI Miftahul Ulum Beru
Authors: Rohmah Afwatun 
Published: September 2022

ABSTRACT
SWOT analysis is generally carried out to determine policies within an institution, organization. The main objective of this research is to be able to perform a SWOT analysis of internal and external factors at MI Miftahul Ulum Beru as an effort to improve the quality of education in schools. The method used in this research is descriptive qualitative with primary data sources from interviews, and secondary observations from documentation. The data analysis stage uses the Miles and Huberman data analysis stage, namely data reduction, data presentation and drawing conclusions. The stages of the research are pre-field, field and data analysis. The results of this research are SWOT analysis is carried out to understand and know the phenomena experienced by the school so that it can be handled in an appropriate way by the parties concerned. Things that need to be considered in the SWOT analysis carried out by researchers are the strategies that will be carried out to improve the quality of education at MI Miftahul Ulum Beru, including: conducting training and gradual development; cross-sectoral approaches and cooperation; and form creative innovations that are constructive and fun for children.
Prescribing Opioids for Chronic Pain: A Quality Improvement Project
Authors: Ajay Geetha 
Published: September 2022

BackgroundSeveral healthcare providers have failed to follow proper opioid prescribing practices to treat chronic pain in recent years. Therefore, the nation is experiencing an epidemic of opioid addiction, which has destroyed many lives. This quality improvement project aims to assess healthcare providers prescribing practices using the Centers for Disease Control and Prevention’s guidelines to treat chronic pain.MethodThe methodology used was the Plan-Do-Study-Act framework. A total of 120 charts were reviewed before the pre and post-implementation of the CDC’s guidelines to assess the prescribing practices of health care providers. Also, the QI project follows SQUIRE’s 2.0 guidelines to describe the prescribing practices of providers. SQUIRE is a framework that helps researchers report new knowledge on improving patient care in the health care system. The literature review section in this article illuminates current evidence of using opioid guidelines and had provided guidance on how to improve opioids prescribing practices among providers. The guidelines can be retrieved at http://squire-statement.org/index.cfm?fuseaction=Page.ViewPage&PageID=471OutcomesUsing the CDC’s guidelines helps to assess the prescribing practices of health care providers, the prescription rates of opioids dropped from 33.3% pre-implementation to 16.7% post-implementation.ConclusionOpioid prescriptions are a significant contributor to the rising opioid epidemic; therefore, educating clinicians about safe prescribing practices is crucial.
Construção paródica por pessoas afásicas
Authors: Calligaris Juliana 
Published: September 2022

Este artigo apresenta um processo de criação teatral performativa com pessoas afásicas participantes do Programa de Expressão Teatral do Centro de Convivência de Afásicos do IEL/UNICAMP. O objetivo foi verificar como se dão os processos interssemióticos interacionais durante o percurso criativo e observar a emergência de semioses coocorrentes multimodais decorrentes da própria via performativa. A emergência de tais semioses manifesta-se nas práticas expressivas, teatrais e performativas das atuadoras afásicas durante a ação teatral.
Novel Covert-Inferior Pelvic Approach with a Subpubic Plate for Anterior Pelvic Ring Fractures
Authors: Yuan Baoming , Ren Guangkai , Cui Yutao , Gao Feng , Miao Weiwei , Li Zhengwei , Zhou Shicheng , Wang Qingyu , Wang Yanbing , Dai Jin , Peng Chuangang , Wu Dankai 
Published: September 2022

Background:Anterior pelvic ring injuries can be treated via Pfannenstiel, modified Stoppa, or ilioinguinal approaches, but these require exposing the abdominal soft tissues and may damage pelvic organs. The scar on the abdominal wall is also unacceptable for some patients. The minimally invasive anterior pelvic ring internal fixator (INFIX) is not ideal for thin patients with easily irritated skin, and it is associated with complications such as femoral nerve palsy, vascular occlusion, and lateral femoral cutaneous nerve injury. In this study, we designed a new external pelvic approach for the treatment of an anterior pelvic ring fracture.Methods:We retrospectively reviewed 28 patients with 36 pubic ramus fractures that had been treated via the covert-inferior pelvic approach. All patients underwent a surgical procedure between August 2019 and January 2021. According to the Nakatani classification, there were 6 cases of type-I fracture, 25 cases of type-II fracture, and 5 cases of type-III fracture. Operative time, blood loss, and postoperative radiographic and computed tomographic (CT) findings were recorded. Patients were followed for fracture healing time, functional status, esthetic satisfaction, and complications.Results:A total of 27 patients had follow-up for at least 12 months (range, 12 to 29 months). Postoperative radiographs and CT scans showed well-positioned plates and screws. The mean preoperative time was 9.4 ± 3.8 days, the mean operative time was 61.3 ± 22.67 minutes, the mean intraoperative blood loss was 63.6 ± 42.62 mL, the mean fracture healing time was 4.1 ± 1.6 months, and the mean Majeed score was 89.74 ± 8.07. There were no complications of nonunion, internal fixation failure, vascular injury, nerve palsy, or hernia. All of the patients were esthetically satisfied with the scar.Conclusions:The covert-inferior pelvic approach combined with a subpubic plate effectively fixed Nakatani type-I, II, and III fractures. The advantages of this method include rapid recovery after the surgical procedure, safety, simplicity, a short learning curve, no damage to abdominal soft tissue, no effect on pubic symphysis micromotion, and esthetic benefits. It may be another option for anterior pelvic ring fractures and can supplement other approaches.Level of Evidence:TherapeuticLevel III. See Instructions for Authors for a complete description of levels of evidence.
Handling strategies of novice and experienced baggage handlers when using an extendable roller track conveyor in the cargo hold of a narrow-body aircraft
Authors: Mostosi Christian , Stéphenne Jean-François , Kempeneers Edelhart , Denis Denys , Plamondon André , Dierick Frédéric 
Published: September 2022

Abstract
Objective: To observe manual load handling using an extendable roller track conveyor (ERC) in a kneeling posture in narrow-body aircrafts.
Methods: At Brussels South Charleroi Airport, we filmed 58 workers with different levels of experience, experienced and novices, loading and unloading aircrafts.
Results: The sequences showed different strategies of the handlers and were sorted according to ergonomic criteria.
Conclusions: Video observation can be useful to analyse and improve posture at work, especially when comparing experienced and novices. A more specific training, using videos would be more effective to prevent musculoskeletal disorders and to allow safer and improved use of an ERC.
Existence of the Mathematical Prediction Equation and its Convergence Condition and its Simplified Derivation
Authors: Gu Xuzan , Wang Zhibin 
Published: September 2022

Abstract
The mathematical prediction equation (MPE) will give the mathematical definition of prediction / forecast to various physical motion (wave) fields. MPE of space-time infinite order accuracy in the Taylor series was proposed in this study (MPE is also an infinite series), and its sufficient and necessary convergence condition was reported, which whold take place of the famous CFL (Courant-Friedrichs-levy) calculation stability condition in textbooks of modern numerical weather forecast. Meanwhile, simplified derivation or inference was given for MPE (it is hoped that the mathematical circle will perfectly prove MPE). The mathematical definition of prediction was provided during derivation, including mathematical relationships between the Euler constant equation and Newton displacement, velocity and acceleration. Furthermore, by combining MPE and its convergence condition with the cubic spline function, closed prediction equations of ideal gas pressure, temperature, and flow fields with space-time second-order accuracy were established. And the success of modern numerical predictions, such as weather forecast, implies the existence of MPE. (It is also hoped that the physics circle will investigate the application of MPE in quantum fields, to discuss the mathematical definition and difference between Newton displacement and Einstein displacement).
The Association Between Albumin Levels and Survival in Patients Treated with Immune Checkpoint Inhibitors: A Systematic Review and Meta-analysis
Authors: Guven Deniz Can , Sahin Taha Koray , Erul Enes , Rizzo Alessandro , Ricci Angela Dalia , Yalcin Suayib 
Published: September 2022

Abstract
The albumin levels could be used as a prognostic biomarker in cancer patients treated with immune checkpoint inhibitors (ICIs) due to close relations with nutritional and inflammatory status. Therefore, we conducted a systematic review and meta-analysis to evaluate the association between survival outcomes and albumin levels in patients treated with ICIs. We conducted a systematic review from the Pubmed, Medline, and Embase databases to filter the published studies until until to 1 June 2022. Thirty-six studies encompassing 8406 cancer patients with advanced disease were included in the meta-analyses. The patients with lower albumin levels had significantly increased risk of death (HR: 1.66, 95% CI:1.52–1.81, p < 0.0001) than patients with higher albumin levels and had increased risk of progression or death compared to patients with higher albumin levels (HR: 1.74, 95% CI:1.39–2.17, p < 0.001). The available evidence demonstrates that albumin levels could be a prognostic biomarker in advanced cancer patients treated with ICIs.
Investigation and Imitation of Human Captains’ Maneuver Using Inverse Reinforcement Learning
Authors: Higaki Takefumi , Hashimoto Hirotada , Yoshioka Hitoshi 
Published: September 2022

Abstract
Automatic collision avoidance is of significant importance to prevent maritime collisions. Although many studies have been conducted in recent years, autonomous system has not completely replaced human captains since it is still difficult to imitate their complicated decisions. Thus, the present paper tries to investigate and imitate experienced captains’ maneuver using maximum entropy inverse reinforcement learning (MaxEnt IRL). We firstly verify that MaxEnt IRL can reproduce appropriate reward function from demonstrative trajectories. Afterwards, we conduct an experiment on a simulator where well-experienced captains maneuver in congested sea and estimate reward from the trajectories. Searching the route which maximizes the obtained reward, finally, we demonstrate the optimized route can avoid collision against multiple ships in compliance with the International Regulations for Preventing Collisions at Sea (COLREGs).
People living with OI raise their VOICE. Community-based exploration with Photovoice online of daily mobility challenges and possible solutions for Adults living with Osteogenesis Imperfecta (OI) in the western world: A pilot-study
Authors: Fink Sascha Helmut , Poppel Mireille Nicoline Maria van , Amort Frank Michael 
Published: September 2022

Abstract
Background. The European Union defines a rare disease as a life-threatening or chronically debilitating disease, with a prevalence of less than 5 per 10,000 persons. Whilst individually rare, there are over 6172 different forms of rare diseases, which together affect at least 18–30 million people in Europe. Osteogenesis Imperfecta (OI) is one of those rare diseases, with a prevalence of about 1 in 15-20,000 persons and is associated with short stature and bone deformities. OI leads to a significant reduction in mobility, which influences daily life ranging from stair climbing, walking long distances or reaching items on the top shelves in grocery shops. However, there is an absence of published data about mobility challenges faced by individuals with OI in a real-world environment and the consequences of these challenges on an individual's quality of life (QoL). To explore the mobility challenges faced on a daily basis, the OI community was asked with photovoice online, which areas of daily living are influenced, which mobility challenges they face daily, and what solutions are perceived as helpful.
Results: In total, six areas of life (living environment, cars and public transport, public spaces, grocery shopping, travelling, and sports), 40 daily mobility challenges and ten solutions proposed by the community could be identified with this approach. The discussion of these results throughout the project was conducted from three perspectives (environmental view, physiological/functional, and psychosocial view). Challenges related to environmental factors are, e.g. lack of accessibility, as well as a floor plan of apartments and can be mitigated mainly through universal and special design approaches. Physiological/functional problems arising from OI characteristics (e.g. high risk of falling due to balance issues, cardiovascular issues when covering long distances), have a high potential for developing assessments with wearables and specific exercise programmes. Challenges of a psychosocial nature, e.g. feelings of loneliness and avoiding a grocery store trip, can be mitigated by building an appropriate network.
Conclusion: In summary, an understanding of daily mobility challenges provides a basis for the development of appropriate guidelines for universal design, assistive technologies as well as assessments in daily life.
Cleavage of semaphorin 4C interferes the neuroprotective effect of semaphorin 4C/Plexin B2 pathway on experimental intracerebral hemorrhage in rats
Authors: Xu Xiang , Li Xiang , Li Haiying , Shen Haitao , You Wanchun , Chen Gang 
Published: September 2022

Abstract
Semaphorin 4C (SEMA4C) and its cognate receptor Plexin B2 are important regulators of axon guidance and are involved in many neurological diseases, in which SEMA4C acts not only as a ligand ("forward" mode) but also as a signaling receptor ("reverse" mode). However, the role of SEMA4C/Plexin B2 in intracerebral hemorrhage (ICH) remains unclear. In this study, ICH in adult male Sprague-Dawley rats was induced by autologous blood injection in the right basal ganglia.In vitro, cultured primary neurons were subjected to OxyHb to imitate ICH injury. Recombinant SEMA4C (rSEMA4C) and overexpressing lentiviruses encoding full-length SEMA4C or secretory SEMA4C (sSEMA4C) were administered to rats by intraventricular injection. First, we found that elevated levels of sSEMA4C in the cerebrospinal fluid (CSF) of clinical patients were associated with poor prognosis. And both SEMA4C and sSEMA4C were increased in brain tissue around hematoma after ICH in rats. Overexpression of SEMA4C could attenuate neuronal apoptosis, neurosis, and neurologic impairment after ICH. However, treatments with rSEMA4C or sSEMA4C overexpression exacerbated neuronal injury. In addition, when treated with SEMA4C overexpression, the forward mode downstream protein RhoA and the reverse mode downstream ID1/3 transcriptional factors of SEMA4C/Plexin B2 signaling were all activated. Nevertheless, when exposed to rSEMA4C or sSEMA4C overexpression, only the forward mode was activated. Thus, sSEMA4C may be a novel molecular biomarker to predict the prognosis of patients with ICH, and the prevention of SEMA4C cleavage is expected to be a promising therapeutic target.
New carbohydrate binding domains identified by phage display based functional metagenomic screens of human gut microbiota
Authors: Akhtar Akil , Lata Madhu , Sunsunwal Sonali , Yadav Amit , LNU Kajal , subramanian srikrishna , Ramya T.N.C. 
Published: September 2022

Abstract
Uncultured microbes represent a huge untapped biological resource of novel genes and gene products. Although recent genomic and metagenomic sequencing efforts have led to the identification of numerous genes that are homologous to existing annotated genes, there remains, yet, an enormous pool of unannotated genes that do not find significant sequence homology to existing annotated genes. Functional metagenomics offers a way to identify and annotate novel gene products. Here, we have constructed a metagenomic phage display library from healthy human fecal samples, and performed functional carbohydrate binding screens against dietary, microbial and host polysaccharides/glycoconjugates in order to mine novel carbohydrate binding domains that might aid gut commensals in the metabolism of complex carbohydrates and in adherence and colonization of the gut. We obtained several protein sequences that do not find a hit to any known Pfam domain but show carbohydrate binding module-like folds as per Alphafold2 prediction. We heterologously expressed, purified and biochemically characterized some of these protein domains and demonstrated their carbohydrate-binding function. Our study reveals several previously unannotated carbohydrate-binding domains, including a levan binding domain and four complex N-glycan binding domains that might be useful for the labeling, visualization, and isolation of these glycans.