bluuebunny/crossref_metadata_2025_split huggingface dataset:
Manajemen Asuhan Kebidanan Intranatal pada Ny. M dengan Serotinus
Authors: Sarfina Cici , Sundari Sundari , Batara Andi Surahman 
Published: February 2022

Menurut organisasi dunia WHO pada tahun 2013 sebanyak 58.500 perempuan meninggal. 99% kematian akibat masalah persalinan atau kelahiran di negara–negara berkembang merupakan angka tertinggi dengan 450 kematian ibu per 100.0000 kelahiran hidup. Jika dibandingkan rasio kematian ibu di 9 negara dan 51 negara maju hal tersebut disebabkan perdarahan 40-50%, infeksi 20-30%, pre-eklamsia 20-30%. Data dari medical record RSUD Labuang Baji Makassar Januari sampai Desember 2019 sekitar 556 ibu yang bersalin dengan angka kejadian serotinus sebanyak 31 kasus. Jenis penelitian ini bersifat deskriptif dengan menggunakan metode studi kasus Manajemen Kebidanan yang terdiri dari 7 langkah Varney, yaitu : Pengumpulan Data Dasar, Interpretasi Data Dasar, Diagnosa Potensial, Tindakan Segera, Menyusun Rencana, Melaksanakan Secara Menyeluruh Asuhan Kebidanan serta Mengevaluasi Keberhasilannya. Asuhan Kebidanan pada ibu bersalin Ny. ‘’M’’ Kala I, fase laten berlangsung (1-3 jam), 3 jam kemudian ibu pada fase aktif deselerasi dengan pembukaan serviks 10 cm. Waktu proses persalinan dari kala I sampai kala IV berlangsung (6 jam 5 menit), keadaan umum Ibu dan Bayi dalam batas normal sampai dipindahkan ke ruang nifas. penelitian ini, bidan dapat menerapkan manajemen asuhan kebidanan sesuai dengan prioritas masalah pasien secara menyeluruh sehingga tindakan yang akan dilakukan bidan dapat dipertanggung jawabkan berdasarkan metode ilmiah.

Kata kunci : persalinan;serotinus
Prototype Pembelajaran Pemanfaatan Energi Baru Terbarukan Berbasis Energi Surya
Authors: Samsurizal Samsurizal , Azzahra Septiannissa , Christiono Chistiono , Fikri Miftahul , Azis Hastuti , Yogianto Agus 
Published: February 2022

The use of renewable energy (EBT) is increasing to achieve the target of 23% by 2025. There needs to be a variety of preparations in welcoming the transition of fossil-based energy to renewable energy. One of them is by improving the quality of human resources that excel in developing the use of renewable energy in Indonesia. Through the Electrical Engineering PkM Team IT-PLN had the opportunity to provide counseling or education to the academic community of MA Al-Khairiyah Rancaranji. The activity is in the form of learning the installation of solar power plant components and the utilization of solar energy in the form of prototype portable plts. The learning improved students' understanding of renewable energy and was able to assemble photovoltaic system components into prototype portable plts with a capacity of 100 WP. Then the tool is tested using a lamp load of 9 watts to find out the amount of current and voltage produced. From this activity, it can be known that the students of MA Al-Khairiyah Rancaranji are very enthusiastic in knowing about renewable energy and can apply it in the surrounding environment.
Flujos de plasma hidrodinámicos y magnetohidrodinámicos. Parte III
Authors: Rotstein Néstor Osvaldo , Bustelo Cancela Ignacio 
Published: February 2022

En este artículo hallamos la expresión general de la topología que el campo magnético adopta para poder limitar las corrientes que se generan a lo largo de sus líneas en plasmas con resistividad no nula. A los efectos de comparar con modelos de plasmas ideales asumimos componente azimutal de la fuerza de Lorentz nula. Mostramos que la intensidad del campo magnético no depende del coeficiente de difusión, como sí lo hacen el campo eléctrico inducido y el flujo másico asociado. El desacople de las isosuperficies de flujo de masa y las superficies de flujo magnético constante hace que el problema matemático no sea ya de variables separables, pero mostramos las condiciones que deben cumplir la densidad de masa (que deja de ser esféricamente simétrica) y el campo de velocidades.
Preliminary analysis of linear and angular kinetic parameters of the gait of individuals with cerebral palsy
Authors: Rodrigues Janaína de Oliveira , Sá Angela Abreu Rosa de , Freitas Deny Gomes , Naves Eduardo Lázaro Martins 
Published: February 2022

Normal gait patterns allow the identification of the normal movement pattern, such as the gait of people with cerebral palsy. Paralympic classification systems aim to include the participation in sports of people with cerebral palsy, minimizing the impact of the injury on the result of the competition. In this context, this study aims to investigate, functionally, the linear and angular kinetic parameters of gait in individuals with cerebral palsy. 15 participants with cerebral palsy were classified into three groups according to the classification of the International Paralympic Committee: 1) T35- diplegic; 2) T36- athetoid ataxic; 3) T37- hemiplegic. For data acquisition, we used a motion capture system in 3 dimensions. The results showed significant differences between the three groups in some linear and angular gait variables, corroborating the qualitative classification process already used by the International Paralympics Committee. In addition, we identified the existence of people with different levels of cerebral palsy within a single functional class of International Paralympics Committee. We found significant differences in some linear and angular gait variables among the classes T35, T36 e T37, which suggest "subgroups" inside each category, and this would prevent a athlete from competing on equal terms with the other competitors.
Serum Soluble ST2 Is a Valuable Prognostic Biomarker in Patients With Acute Heart Failure
Authors: Wang Zeyu , Pan Xin , Xu Hong , Wu You , Jia Xiaomin , Fang Yiling , Lu Yi , Xu Yawei , Zhang Ji , Su Yang 
Published: February 2022

BackgroundThis study aimed to investigate the clinical utility of different soluble suppression of tumorigenicity 2 (sST2) levels in assessing the severity and prognosis of patients with acute heart failure (AHF).MethodsThis was a prospective cohort study. Three hundred and thirty-one consecutively enrolled AHF patients from March 2018 to November 2019 were divided into 3 subgroups according to sST2 levels: T1 (1.15–7.70 ng/ml; N = 110), T2 (7.71–17.24 ng/ml; N = 111), and T3 (17.26–47.42 ng/ml; N = 110). The patients were followed up for a median period of 21.0 months for the development of the primary endpoint. Cox proportional hazards model was performed to evaluate the prognostic value of sST2 for the clinical outcomes.ResultsThe mean age of patients was 69 years (range, 34–93 years), and 70.4% were male. During the follow-up period, 63 participants died. Patients with higher sST2 levels had lower left ventricular ejection fraction (correlation = −0.119, P = 0.031), and higher New York Heart Association classification (correlation = 0.443, P &lt; 0.001) and N-terminal pro-B type natriuretic peptide (NT-proBNP) levels (correlation = 0.392, P &lt; 0.001). Higher sST2 was also associated with creatinine, urea nitrogen, hemoglobin, and left ventricular mass index. Multivariate analysis revealed that sST2 (per log unit, hazard ratio: 2.174, 95% confidence interval [CI] 1.012–4.67, P = 0.047) and NT-proBNP (per log unit, HR 2.171, 95%CI 1.169–4.032, P &lt; 0.001) were independent risk factors for the primary outcome in all patients with AHF.ConclusionsST2 can provide prognostic information in AHF. The higher the sST2 level in patients with AHF, the higher the incidence of cardiovascular death.
Uterine Cavity Irrigation With Office Hysteroscopy During Ovarian Stimulation for IVF: A Randomized Controlled Trial
Authors: Ghasemi Marzieh , Aleyasin Ashraf , Fatemi Human M. , Ghaemdoust Faezeh , Shahrakipour Mahnaz 
Published: February 2022

ObjectiveThis was a non-blinded randomized controlled study to evaluate whether endometrial irrigation via office hysteroscopy during the early follicular phase would lead to a higher level of live birth rates compared to no irrigation in the fresh embryo transfer cycle.MethodThe study was conducted in Tehran university of medical sciences from June 2015 to June 2016. women under the age of 40 with primary infertility without history of previous IVF/ICSI or hysteroscopic examination, were included. Controlled ovarian hyperstimulation was done. Hysteroscopy was performed in the early mid-follicular phase of a stimulation cycle (day 5-7) with a vaginoscopy approach and saline irrigation in hysteroscopy group. Embryo-transfer was done in the same cycle.Results228 patients completed their participation in the study. In the fresh cycle, clinical pregnancy rate was 46% in the hysteroscopy group and 40.43% in the control group. (p-value= 0.326, RR= 1.16 [95%CI: 0.862 to 1.56]). Live birth rate was 41.28% in the hysteroscopic group and 31.93% in the control group (p-value=0.143, RR= 1.293 [95%CI: 0.916 to 1.825]). For those patients having surplus cryopreserved embryos, after 2 months, a second embryo transfer was performed. The cumulative LBR was 44.05% in the hysteroscopic group and 32.25% in the control group (p-value=0.029, RR= 1.368 [95%CI: 1.031 to 1.815], RD= 11.9% [95%CI: 1.2% to 22.3%] and NNT= 8 [95%CI: 4 to 85]).ConclusionThe current study clearly demonstrated a significantly higher cumulative live birth rate in the intervention group.Clinical Trial Registration[https://www.irct.ir/trial/19586], identifier IRCT2016011022795N2.
Theoretically Modified Optical Length Research on the Physical Boundary of the Double-Heterogeneous System
Authors: Lei Lou , Xiaoming Chai , Dong Yao , Lianjie Wang , Mancang Li , Liang Chen , Xiaoli Liu , Hongbo Zhang , Sinan Li , Xiao Tang , Nan Zhou 
Published: February 2022

Because of the double-heterogeneity (DH), dispersed particle-type systems cannot be described by traditional neutronic programs, and the volumetric homogenization method (VHM) will bring reactivity calculation deviation because of ignoring the spatial self-shielding effect of the particles. In this article, the relationship between the reactivity calculation deviation and the optical length of dispersed particle-type fuel and different types of burnable poisons is analyzed. Also then, it was proposed that the influencing factors of reactivity calculation deviation can be integrated to a physical quantity named theoretically modified optical length containing the influencing factors mentioned earlier. In addition, the DH physical boundary has forward that, when the theoretically modified optical length is larger than 10−4, reactivity calculation deviation of volumetric homogenization method will be larger than 100 pcm, and the DH of the dispersed particle-type systems should be considered.
Determining Sex-Based Differences in Inflammatory Response in an Experimental Traumatic Brain Injury Model
Authors: Scott Michael C. , Prabhakara Karthik S. , Walters Andrew J. , Olson Scott D. , Cox Charles S. 
Published: February 2022

IntroductionTraumatic brain injury is a leading cause of injury-related death and morbidity. Multiple clinical and pre-clinical studies have reported various results regarding sex-based differences in TBI. Our accepted rodent model of traumatic brain injury was used to identify sex-based differences in the pathological features of TBI.MethodsMale and female Sprague-Dawley rats were subjected to either controlled-cortical impact (CCI) or sham injury; brain tissue was harvested at different time intervals depending on the specific study. Blood-brain barrier (BBB) analysis was performed using infrared imaging to measure fluorescence dye extravasation. Microglia and splenocytes were characterized with traditional flow cytometry; microglia markers such as CD45, P2Y12, CD32, and CD163 were analyzed with t-distributed stochastic neighbor embedding (t-SNE). Flow cytometry was used to study tissue cytokine levels, and supplemented with ELISAs of TNF-⍺, IL-17, and IL-1β of the ipsilateral hemisphere tissue.ResultsCCI groups of both sexes recorded a higher BBB permeability at 72 hours post-injury than their respective sham groups. There was significant difference in the integrated density value of BBB permeability between the male CCI group and the female CCI group (female CCI mean = 3.08 x 108 ± 2.83 x 107, male CCI mean = 2.20 x 108 ± 4.05 x 106, p = 0.0210), but otherwise no differences were observed. Traditional flow cytometry did not distinguish any sex-based difference in regards to splenocyte cell population after CCI. t-SNE did not reveal any significant difference between the male and female injury groups in the activation of microglia. Cytokine analysis after injury by flow cytometry and ELISA was limited in differences at the time point of 6 hours post-injury.ConclusionIn our rodent model of traumatic brain injury, sex-based differences in pathology and neuroinflammation at specified time points are limited, and only noted in one specific analysis of BBB permeability.
Inflammatory Markers, Pulmonary Function, and Clinical Symptoms in Acute COVID-19 Among Non-Hospitalized Adolescents and Young Adults
Authors: Lund Berven Lise , Selvakumar Joel , Havdal Lise , Stiansen-Sonerud Tonje , Einvik Gunnar , Leegaard Truls Michael , Tjade Trygve , Michelsen Annika E. , Mollnes Tom Eirik , Wyller Vegard Bruun Bratholm 
Published: February 2022

SummaryMild, subacute COVID-19 in young people show inflammatory enhancement, but normal pulmonary function. Inflammatory markers are associated with age and male sex, whereas clinical symptoms are associated with age and female sex, but not with objective disease markers.BackgroundCoronavirus Disease 2019 (COVID-19) is widespread among adolescents and young adults across the globe. The present study aimed to compare inflammatory markers, pulmonary function and clinical symptoms across non-hospitalized, 12 – 25 years old COVID-19 cases and non-COVID-19 controls, and to investigate associations between inflammatory markers, clinical symptoms, pulmonary function and background variables in the COVID-19 group.MethodsThe present paper presents baseline data from an ongoing longitudinal observational cohort study (Long-Term Effects of COVID-19 in Adolescents, LoTECA, ClinicalTrials ID: NCT04686734). A total of 31 plasma cytokines and complement activation products were assayed by multiplex and ELISA methodologies. Pulmonary function and clinical symptoms were investigated by spirometry and questionnaires, respectively.ResultsA total of 405 COVID-19 cases and 111 non-COVID-19 controls were included. The COVID-19 group had significantly higher plasma levels of IL-1β, IL-4, IL-7, IL-8, IL-12, TNF, IP-10, eotaxin, GM-CSF, bFGF, complement TCC and C3bc, and significantly lower levels of IL-13 and MIP-1α, as compared to controls. Spirometry did not detect any significant differences across the groups. IL-4, IL-7, TNF and eotaxin were negatively associated with female sex; eotaxin and IL-4 were positively associated with age. Clinical symptoms were positively associated with female sex and age, but not with objective disease markers.ConclusionsAmong non-hospitalized adolescents and young adults with COVID-19 there was significant alterations of plasma inflammatory markers in the subacute stage of the infection. Still, pulmonary function was normal. Clinical symptoms were independent of inflammatory and pulmonary function markers, but positively associated with age and female sex.
The Relationship Between Successful Aging and All-Cause Mortality Risk in Older Adults: A Systematic Review and Meta-Analysis of Cohort Studies
Authors: Mao Lifen , Yin Rulan , Cai Jianzheng , Niu Mei'e , Xu Lan , Sui Wenjie , Shi Xiaoqing 
Published: February 2022

BackgroundThis meta-analysis aimed to explore the effect of successful aging (SA) on all-cause mortality risk in older people to provide a theoretical basis for promoting SA.MethodsPubMed, Embase, CINAHL, CNKI, and WanFang databases (inception to March 4, 2021) were searched for cohort studies to evaluate the relationship between SA and mortality in older people. A random-effects model was used to synthesis hazard ratio and 95% confidence intervals. Quality assessment was performed using the Newcastle–Ottawa scale. All statistical analyses were conducted in STATA 16.0.ResultsIn total, 21,158 older adults from 10 studies were included in the current systematic review and meta-analysis. The SA group tended to have 50% lower risk of all-cause mortality than the non-SA group (pooled hazard ratio = 0.50, 95% confidence intervals: 0.35–0.65, P &lt; 0.001; I2 = 58.3%). The risk of all-cause mortality in older people increased by 17% for each unit increment in the healthy aging index (HAI) (I2 = 0%, P = 0.964). Compared with the reference group (HAI 0-2), older people with HAI 3-4, HAI 5-6, and HAI 7-10 had 1.31-fold, 1.73-fold, and 2.58-fold greater risk of all-cause mortality, respectively. Subgroup analysis did not reveal possible sources of heterogeneity.ConclusionsThis meta-analysis suggests that older adults with SA reduced the risk of all-cause mortality by 50%. However, few interventional studies have been conducted. Therefore, healthcare providers must be aware of the relationship between SA and mortality risk and actively develop intervention methods for helping old people achieve SA.
Adherence, Safety, and Effectiveness of Medical Cannabis and Epidemiological Characteristics of the Patient Population: A Prospective Study
Authors: Bar-Lev Schleider Lihi , Mechoulam Raphael , Sikorin Inbal , Naftali Timna , Novack Victor 
Published: February 2022

BackgroundDespite the absence of rigorous prospective studies, there has been an increase in the use of cannabis-based medicinal products. During the study period, the use of medical cannabis in Israel was tightly regulated by national policy. Through a prospective study of approximately 10,000 patients, we aimed to characterize the medical cannabis patient population as well as to identify treatment adherence, safety, and effectiveness.Methods and FindingsIn this study of prescribed medical cannabis patients, adherence, safety, and effectiveness were assessed at 6 months. Treatment adherence was assessed by the proportion of patients purchasing the medication out of the total number of patients (excluding deceased cases and patients transferred to another cannabis clinic). Safety was assessed by the frequency of the side-effects, while effectiveness was defined as at least moderate improvement in the patient condition without treatment cessation or serious side-effects. The most frequent primary indications requiring therapy were cancer (49.1%), followed by non-specific pain (29.3%). The average age was 54.6 ± 20.9 years, 51.1% males; 30.2% of the patients reported prior experience with cannabis. During the study follow-up, 1,938 patients died (19.4%) and 1,735 stopped treatment (17.3%). Common side-effects, reported by 1,675 patients (34.2%), were: dizziness (8.2%), dry mouth (6.7%), increased appetite (4.7%), sleepiness (4.4%), and psychoactive effect (4.3%). Overall, 70.6% patients had treatment success at 6 months. Multivariable logistic regression analysis revealed that the following factors were associated with treatment success: cigarette smoking, prior experience with cannabis, active driving, working, and a young age. The main limitation of this study was the lack of data on safety and effectiveness of the treatment for patients who refused to undergo medical assessment even at baseline or died within the first 6 months.ConclusionsWe observed that supervised medical-cannabis treatment is associated with high adherence, improvement in quality of life, and a decrease in pain level with a low incidence of serious adverse events.
Altered Spontaneous Brain Activity and Functional Integration in Hemodialysis Patients With End-Stage Renal Disease
Authors: Su Huanhuan , Fu Shishun , Liu Mengchen , Yin Yi , Hua Kelei , Meng Shandong , Jiang Guihua , Quan Xianyue 
Published: February 2022

PurposeUsing the amplitude of low-frequency fluctuation (ALFF) and functional connectivity (FC) algorithm to study the alteration of brain function in hemodialysis patients with end-stage renal disease (ESRD).Patients and MethodsWe recruited 20 patients with ESRD on regular hemodialysis and 17 healthy controls (HCs). All of the participants underwent resting-state fMRI (rs-fMRI), neuropsychological tests, and blood biochemical examination. The individual ALFF values between the two groups were tested by an independent sample t-test. Then, we set the altered ALFF brain areas as seed regions of interest (ROIs), and FC analysis was used to investigate the functional integration patterns between the seed ROI and the voxels within the whole brain.ResultsThe ALFF values of the right precuneus and angular gyrus (RAG) in the ESRD group were lower than those in the HC subjects, but the right precentral gyrus showed higher ALFF values in patients. Hemoglobin (Hb) was negatively correlated with the ALFF values of the right precentral gyrus, and the ALFF values of the right precuneus were negatively correlated with line-tracing test (LTT) scores in patients with ESRD. Patients with ESRD show decreased connectivity between the RAG and the left precuneus, right superior frontal gyrus (RSFG), and the connectivity within the RAG was weak. In addition, FC in the RAG-right cuneus, right precuneus-left supramarginal gyrus was enhanced in the patient group.ConclusionOur research suggested that, in hemodialysis patients with ESRD, the brain areas with abnormal spontaneous brain activity and FC are mainly located in the default mode network (DMN) regions. Hb and the LTT results were correlated with abnormal spontaneous brain activity. These findings provide additional evidence to understand the possible underlying neuropathological mechanisms in patients with ESRD.
A Multielement Prognostic Nomogram Based on a Peripheral Blood Test, Conventional MRI and Clinical Factors for Glioblastoma
Authors: Rao Changjun , Jin Jinghao , Lu Jianglong , Wang Chengde , Wu Zerui , Zhu Zhangzhang , Tu Ming , Su Zhipeng , Li Qun 
Published: February 2022

BackgroundGlioblastoma (GBM) is one of the most malignant types of tumors in the central nervous system, and the 5-year survival remains low. Several studies have shown that preoperative peripheral blood tests and preoperative conventional Magnetic Resonance Imaging (MRI) examinations affect the prognosis of GBM patients. Therefore, it is necessary to construct a risk score based on a preoperative peripheral blood test and conventional MRI and develop a multielement prognostic nomogram for GBM.MethodsThis study retrospectively analyzed 131 GBM patients. Determination of the association between peripheral blood test variables and conventional MRI variables and prognosis was performed by univariate Cox regression. The nomogram model, which was internally validated using a cohort of 56 GBM patients, was constructed by multivariate Cox regression. RNA sequencing data from Gene Expression Omnibus (GEO) and Chinese Glioma Genome Atlas (CGGA datasets were used to determine peripheral blood test-related genes based on GBM prognosis.ResultsThe constructed risk score included the neutrophil/lymphocyte ratio (NLR), lymphocyte/monocyte ratio (LMR), albumin/fibrinogen (AFR), platelet/lymphocyte ratio (PLR), and center point–to-ventricle distance (CPVD). A final nomogram was developed using factors associated with prognosis, including age, sex, the extent of tumor resection, IDH mutation status, radiotherapy status, chemotherapy status, and risk. The Area Under Curve (AUC) values of the receiver operating characteristic curve (ROC) curve were 0.876 (12-month ROC), 0.834 (24-month ROC) and 0.803 (36-month ROC) in the training set and 0.906 (12-month ROC), 0.800 (18-month ROC) and 0.776 (24-month ROC) in the validation set. In addition, vascular endothelial growth factor A (VEGFA) was closely associated with NLR and LMR and identified as the most central negative gene related to the immune microenvironment and influencing immune activities.ConclusionThe risk score was established as an independent predictor of GBM prognosis, and the nomogram model exhibit appropriate predictive power. In addition, VEGFA is the key peripheral blood test-related gene that is significantly associated with poor prognosis.