bluuebunny/crossref_metadata_2025_split huggingface dataset:
Experimental investigation of tool wear evolution during turning operation based on analysis of vibration and cutting forces signals
Authors: Babouri Mohamed Khemissi , Ouelaa Nouredine , Djamaa Mohamed Cherif , Ouelaa Zakarya , Chaabi Lilia , Djebala Abderrazek 
Published: November 2022

Abstract
Cutting tool wear is one of the major physical phenomena to be studied in order to optimize the production and to guarantee the quality of manufactured products. Indeed, the wear affects the quality of the machined surfaces, the durability of the cutting tool and the imposed geometric tolerances. Since uncontrolled wear can lead to premature tool breaking and therefore a drop in productivity, monitoring the machining process is a necessary important task. To evaluate the wear of a cutting insert while turning process, this paper aims to combine experimental results from vibration and cutting forces with numerical methodologies based on the application of several signal-processing techniques, especially the Optimized Wavelet Multi-Resolution Analysis (OWMRA) to analyze the measured cutting forces signals during the cutting process. The main objective is to find a correlation between the wear and several indicators established from these measured signals, allowing the prediction of the tool wear as early as possible. The results obtained after the application of the OWMRA allowed the denoising of the measured signals and revealed two peaks, which appear below and above the tool’s resonance frequency. The amplitude evolution of these two peaks is directly related to the effect of the tool wear on the natural frequency band.
Predicting Malicious Behavior of Employees using Game Theory
Authors: Sepehrzadeh Hamed 
Published: November 2022

Abstract
Information security is a crucial issue nowadays in organizations. Security flaws are serious threats to an organization. Every organization has sensitive information that may be threatened by malicious adversaries and even employees (insiders). In order to limit security incidents, each organization must concentrate on employee’s behavior. Indeed, employees of an organization act as a natural safeguard for information. Therefore, predicting the behavior of internal employees against the information assets of the organization is very important. To this end, this paper proposes a game-theoretic modelling approach to capture the interaction between employees and organization to predict malicious employees (insiders) and organizations behavior with incomplete information. The game parameters are some important elements of security culture including influencing and organizational behavior factors, and security related factors. By solving the game model, Nash equilibriums are computed and best-response strategies for the players are recognized. Quantitative evaluation of the information security of organization can be done according to the probability of performing unacceptable behavior by employees and the probability of organization investment in order to increase the organizational security culture.
The criterion for the existence of principal eigenvalues of time periodic some nonlocal reaction diffusion operators and applications
Authors: Zhang Dongwen 
Published: November 2022

Abstract
Using several new notions of the generalized principal eigenvalue, we exhibit three distinct sufficient conditions for the existence of the principal eigenfunction of a nonlocal dispersal operator and apply the established theory to study the behavior of the solution of the corresponding nonlocal dispersal equations in the literature. Relations between these generalized principal eigenvalues, the dependence of their different parameters, and several properties of nonlocal operators are further explored. Our approach is to construct several new generalized principal eigenvalues and use new calculations techniques to overcome the fundamental difficulties caused by the unsuitable Harnack-type inequality for elliptic-type nonlocal dispersal equations [33] and the presence of the time dependence of the nonlinear function.
Mathematics Subject Classification: 35K57; 47G20; 92D25.
Reimagining tonne-year accounting to capture the climate benefit of temporary carbon storage
Authors: Matthews H. Damon , Zickfeld Kirsten , Koch Alexander , Luers Amy 
Published: November 2022

Abstract
Nature-based climate solutions have the potential to contribute to climate mitigation, but the vulnerability of land carbon to disturbances means that any efforts to slow or reverse land carbon losses will likely result in only temporary storage. Tonne-year accounting, which integrates the amount of carbon over the time that it remains stored, has been proposed as a method to measure the value of temporary relative to permanent carbon storage. Here we show that using tonne-year accounting to establish an equivalency of temporary with permanent storage is not grounded in climate science. However, a reimagined approach to tonne-year accounting could be effectively used as a metric to track the contribution of temporary carbon storage towards climate mitigation goals. We show that in a scenario where the total number of tonne-years accumulates at a constant or increasing rate, this results in a sustained or increasing climate benefit. However, as the rate of accumulation of tonne-years slows, this temperature benefit is eroded, and is lost completely when tonne-years stop increasing. This implies that if the world is able to sustain an increasing number of tonne-years alongside achieving net-zero fossil fuel CO2 emissions, then the resulting carbon storage (even if only temporary) would contribute to lowering peak temperature. Tonne-years of temporary carbon storage therefore have considerable climate value, not if treated interchangeably with permanent storage or fossil fuel emissions, but rather if quantified as an independent contribution to lowering the global temperature peak.
Application and limitation of a biological clock-based method for estimating time of death in forensic practices
Authors: Kimura Akihiko , Ishida Yuko , Nosaka Mizuho , Ishigami Akiko , Yamamoto Hiroki , Kuninaka Yumi , Hata Satoshi , Ozaki Mitsunori , Kondo Toshikazu 
Published: November 2022

Abstract
Estimating time of death is one of the most important issues in forensic practice. Here, we assessed the applicability, limitation and reliability of a biological clock-based method developed by us. We analyzed the expression of clock genes, BMAL1 and NR1D1, in the heart of the deceased in 318 cases with a defined time of death by real-time RT-PCR. For estimating time of death, we selected two parameters, the NR1D1/ BMAL1 ratio and BMAL1/NR1D1 ratio for death in the morning and evening, respectively. The NR1D1/ BMAL1 ratio was significantly higher in the cases of morning death, while the BMAL1/NR1D1 ratio was significantly higher in the cases of evening death. Gender, age, postmortem interval and most causes of death did not significantly affect the two parameters, except in infant and elderly cases as well as those with severe brain injury. We examined the effects of water intoxication-induced cerebral edema on clock gene expression in mouse hearts and found that cerebral edema alters clock gene expression in this tissue. Based on our findings, we concluded that our method can be applied to forensic practice. However, the method should be applied with caution in infant and elderly cases as well as those with severe brain injury.
Effect of sonification types in upper-limb movement: a quantitative and qualitative study in hemiparetic and healthy participants
Authors: Peyre Iseline , Roby-Brami Agnès , Segalen Maël , Giron Alain , Caramiaux Baptiste , Marchand-Pauvert Véronique , Pradat-Diehl Pascale , Bevilacqua Frédéric 
Published: November 2022

Abstract
Background: Movement sonification, the use of real-time auditory feedback linked to movement parameters, have been proposed to support rehabilitation. Nevertheless, if promising results have been reported, the effect of the type of sound used has not been studied systematically, and mechanisms involved during movement execution with sonification remain poorly understood. The aim of this study was to investigate in a single session the effect of different types of sonification both quantitatively and qualitatively on patients with acquired brain lesions and healthy participants. This experiment should be considered as a first step before establishing a longitudinal clinical rehabilitation study.
Methods: An experimental setup enabling arm sonification was developed using three different categories of sonification (direct sound modulation, musical interaction, and soundscape). Simple moving forward movements performed while sliding on a table with both arms were investigated with all participants. Quantitative analysis on the movement timing were performed, and different comparisons were processed (sound / no sound, affected arm / less affected arm, category and type of sonification). Qualitative analysis of semi-structured interviews were also conducted, as well as neuropsychological evaluation of music perception.
Results: For both the patient and healthy groups (15 participants each), average duration for performing the arm movement is significantly longer with sonification compared to the no-sound condition (p<10-3). Differences were also observed between the sound categories in the case of the paretic arms of patients and the dominant arms of healthy participants (p<0.05). Qualitative analysis of semi-structured interviews revealed the motivational and affective aspects of each type of sonification. Most participants of both groups preferred to complete the task with sound, and more precisely with one that uses sound of nature environment (soundscape).
Conclusion: Overall, our results confirm that the sonification has an effect on the temporal execution of the movement during a single-session. This effect is variable among participants, which requires further studies to better understand. Globally, sonification is welcomed by the participants, and we found convergent and differentiated appreciations of the different sonification types. This enables us to provide researchers with recommendations for clinical studies for personalized music-guided rehabilitation.
Successful engraftment of bladder organoids in de-epithelialized mouse colon.
Authors: Suda Kazuto , Matsumoto Yuka , Ochi Takanori , Koga Hiroyuki , Lane Geoffrey J. , Hattori Nobutaka , Nakamura Tetsuya , Yamataka Atsuyuki 
Published: November 2022

Abstract
Purpose
To engraft bladder organoids (BO) on de-epithelialized mouse colon using an epithelial replacement technique.
Methods
BO cultured using bladder specimens from enhanced green fluorescent protein (EGFP) transgenic mice were engrafted to replace proximal colon epithelium stripped from an approximately 1cm long target site in syngeneic wild-type recipient mice (n = 9) by exposure to ethylenediaminetetraacetic acid by infusion and flushing with phosphate buffered saline. Target sites were harvested on postoperative days 2, 7, and 28 for hematoxylin-eosin staining and immunofluorescence.
Results
Histology on postoperative days 7 and 28 showed BO derived EGFP + cells forming multiple layers on the luminal surface of the colon. Immunohistochemistry showed that EGFP + areas were positive for CK5 and CK14, markers for basal and immature subtype urothelium, respectively, but negative for CA2, a marker for colonic epithelium. Ki67 was detected predominantly in the basal parts of EGFP + areas on post-operative day 7 and day 28.
Conclusions
This is the first report of successful engraftment of BO in de-epithelialized colon with urothelial tissue reconstituted by actively-proliferating cells. This technique could be developed for augmentation cystoplasty to prevent bladder calculi formation and malignant transformation.
Stability in the Outdoors: Winter conditions elicit modified stepping behaviour but no additional compensation from the ankle or trunk strategies
Authors: Best Aaron N. , Wu Amy R. 
Published: November 2022

Abstract
Healthy humans are proficient at maintaining stability when faced with diverse walking conditions, however, the control strategies that lead to this proficiency are unclear. Previous laboratory-based research has predominantly concluded that corrective stepping is the main strategy, but whether this finding holds when facing everyday obstacles outside of the laboratory is uncertain. We investigated changes in gait stability behaviour when walking outdoors in the summer and winter, hypothesizing that as ground conditions worsened in the winter, the stepping strategy would be hindered. Stability would then be maintained through compensatory strategies such as with ankle torques and trunk rotation. Data was collected in the summer and winter using inertial sensors to collect kinematics and instrumented insoles to collect vertical ground reaction forces. Using the goodness of fit for a multivariate regression between the centre of mass state and foot placement we found that, counter to our hypothesis, stepping was not hindered by winter conditions. Instead, the stepping strategy was modified to increase the anterior-posterior margin of stability, increasing the resistance to a forward loss of stability. With stepping being unhindered, we did not observe any additional compensation from the ankle or trunk strategies.
Changes of serum IgG glycosylation patterns in rheumatoid arthritis
Authors: Deng Xiaoyue , Liu Xiaomin , Zhang Yan , Ke Dan , Yan Rui , Wang Qian , Tian Xinping , Li Mengtao , Zeng Xiaofeng , Hu Chaojun 
Published: November 2022

Abstract
Objective
RA is a prevalent systemic autoimmune disease, whose diagnosis is based significantly on autoantibody detection. This study aims to investigate the glycosylation profile of serum IgG in RA patients using high-throughput lectin microarray technology.
Method
Lectin microarray containing 56 lectins was applied to detect and analyze the expression profile of serum IgG glycosylation in 214 RA patients, 150 disease controls (DC), and 100 healthy controls (HC). Significant differential glycan profiles between the groups of RA and DC/HC as well as RA subgroups were explored and verified by lectin blot technique. The predicted models were created to evaluate the feasibility of those candidate biomarkers.
Results
As a comprehensive analysis of lectin microarray and lectin blotting, results showed that compare to HC and DC groups, serum IgG from RA patients had a higher affinity to the SBA lectin (recognizing glycan GalNAc). For RA subgroups, RA-seropositive group had higher affinities to the lectins of MNA-M (recognizing glycan mannose) and AAL (recognizing glycan fucose), and RA-ILD group had higher affinities to the lections of ConA (recognizing glycan mannose) and MNA-M while a lower affinity to the PHA-E (recognizing glycan Galβ4GlcNAc) lectin. The predicted models indicated corresponding feasibility of those biomarkers.
Conclusion
Lectin microarray is an effective and reliable technique for analyzing glycan structure. RA, RA-seropositive, and RA-ILD patients exhibit distinct glycan profiles, respectively. Altered levels of glycosylation may be related to the pathogenesis of the disease, which could provide a direction for new biomarkers identification.
Adherence to Glucose Monitoring with intermittently scanned Continuous Glucose Monitoring in patients with Type 1 Diabetes
Authors: Sousa Carolina , Neves João Sérgio , Dias Cláudia Camila , Sampaio Rute 
Published: November 2022

Abstract
Purpose: This study aims to predict the Intermittently scanned continuous glucose monitoring (isCGM) adherence behavior of patients with Type 1 Diabetes.
Methods: Patients with Type 1 Diabetes mellitus using FreeStyle Libre™ System (FL), a isCGM device, that attended the “Insulin Infusion Pump clinic” at Centro Hospitalar de São João were enrolled and evaluated for sociodemographic and clinical characterization, beliefs and concerns about Diabetes Mellitus, as well as isCGM’s perceptions. Intermittently scanned continuous glucose monitoring data were collected to characterize monitoring patterns and to measure isCGM’s adherence - FL average of scans/day.
Results: Seventy-two patients with a mean of 30.36 years (sd=11.35) participate in this study. A median of 7 scans/day was performed. The adherence predictors found was Age (β=0.191, p=0.006), Time in target (β= 0.530, p=0.002), isCGM Necessity (β=2.631, p=0.048), Body Mass Index (β=-0.549, p=0.017) and Sex (β=-3.996; p=0.011).
Conclusions: This study emphasizes the relevance of glucose monitoring adherence in disease control and shows that males of younger ages, presenting with higher body mass index levels, lower time in target, and reporting lower isCGM necessity are less adherent to isCGM. Therefore, these patients should be closely followed and object of personalized strategies to promote treatment adherence.
Application of SWOT and AHP analysis on aquaculture farms (South-western of Mediterranean Sea)
Authors: Maouel Djamila , Fellah Houda , Difallah Fatma Zohra , Milla Toufik 
Published: November 2022

Abstract
In Algeria, aquaculture is in full development; aquaculture farm projects for both marine and freshwater species designed to meet the needs of the fish market and to increase in fish production. However, the contributions from these activities remain weak and insufficient. Thus, and in order to understand the dysfunctions at the origin of this problem, in the present study, aquaculture farms, in particular marine fish farming, have been analyzed using a management tool, in this case SWOT (Strengths, Weaknesses, Opportunities, Threats), combined with the AHP (Analytic Hierarchy Process). Surveys have been carried out among investors of aquaculture farms, order to gather the data necessary for the analysis. It emerges from the priority threats and weaknesses affecting the global environment of these enterprises, such as the absence of a structured market for aquaculture products, the climate change and the health crisis which blocked imports of raw materials (fingerlings, fish feed…) and reduced the workforce at farm level (containment). The impact of the latter covers that of factors of forces and opportunities, in this case, the quality of the juvenile fish and the food, which remains low for the development of fish production. Thus, in order to hope for a balanced environment and therefore a better performance of aquaculture farms in question, it is recommended a strategy based on the improvement of strengths and opportunities of these companies and the reduction of their weaknesses and threats that affect them.
Anisotropic strange stars in Einstein Gauss-Bonnet Gravity
Authors: Dey Sagar , Paul Bikash Chandra 
Published: November 2022

Abstract
We obtain a class of new anisotropic relativistic solution in Einstein Gauss-Bonnet (EGB) gravity with Finch-Skea metric in hydrostatic equilibrium. The relativistic solutions are employed to construct anisotropic stellar models for strange star with MIT Bag equation of state pr= ⅓ ( ρ - 4 Bg), where Bg is the Bag constants. Considering the mass and radius of a known star PSR J0348+0432 we construct stellar models in the framework of D- dimensions. We also predict the mass and radius of stars for different model parameters. The Gauss-Bonnet coupling term (α) plays an important role in determining the density, pressure, anisotropy profiles and other features. The stability of the stellar models are probed analyzing the different energy conditions, variation of sound speed and adiabatic stability conditions inside the star. The central density and pressure of a star in EGB gravity are found to have higher values compared to that one obtains in Einstein gravity (α =0). We also explore the effect of extra dimensions for the physical features of a compact object. For this we consider D=5 and D=6 to obtain a realistic stellar model and found that in the formal case both positive and negative values of α are allowed. But in the later case, only α < 0 permits compact object in the Finch-Skea metric. We determine the best fit values of the model parameters for a number of observed stars for acceptable stellar models.
Macular microvasculature in patients with thyroid-associated orbitopathy compared to healthy individuals, foveal avascular zone area as a biomarker for disease activity
Authors: Abrishami Mojtaba , Sabermoghaddam Aliakbar , Salahi Zeinab , Bakhtiary Elham , Shariati Mehrdad Motamed 
Published: November 2022

Abstract
Purpose: The aim of this study was to evaluate macular blood flow in patients with thyroid-associated orbitopathy (TAO) compare to healthy subjects.
Methods: This is a cross-sectional study with the convenience sampling method. Macular flow density was assessed using optical coherence tomography angiography (OCTA) and compared between patients with TAO and healthy individuals. We also compared macular flow density in two subgroups of patients based on clinical activity score (CAS).
Results: Eighty–five cases, including 30 healthy individuals and 55 patients with TAO, participated. The foveal avascular zone (FAZ) area was significantly higher in the patient group than in the control. A comparison of flow data between the two subgroups of patients showed a significant difference in the FAZ area (p=0.041).
Conclusion: We showed that the FAZ area has an increasing trend from healthy individuals to active TAO patients and can be considered a possible candidate for monitoring the disease activity and thyroid-associated vasculopathy.
Expression of STAT family and its potency to prognosis in uterine corpus endometrial carcinoma
Authors: Li Luyi , Li Sihui , Zhou Hongdi 
Published: November 2022

Abstract
Purpose
Signal Transducer and Activators of Transcription (STAT) family is a full set of transcription factors, acting a pivotal role in normal physiological and pathological process. Evidence manifests these transcription factors are involved in tumorigenesis of various cancers including uterine corpus endometrial carcinoma (UCEC). Whereas, the differential expression pattern and prognostic value of individual STAT remain to be elucidated in UCEC.
Methods and results
In this study, the data of expression (HTSeq-FPKM) and data of clinical pathology of UCEC patients and normal samples of endometrium were downloaded via the data portal of TCGA.Based on TCGA database, STAT1 was increased, conversely STAT3/5A/5B/6 were decreased in UCEC patients. Furthermore, expressions of STAT1 and STAT6 were markedly associated with TNM stage and tumor grade. Multivariate analysis adjusted for histological type, patient age, tumor grade and TMN stage revealed that STAT4 and STAT6 were independent prognostic factors for overall survival (OS). Additionally, gene set enrichment analysis (GSEA) revealed that pathways of endometrial cancer, JAK-STAT, WNT, mTOR and p53 were differentially enriched in STAT1 high expression phenotype. And STAT1 was co-expressed with pik3ca, β-catenin(CTNNB1), wnt3a, wnt7a genes, as well, could co-mutated with pik3ca,TP53, APC, which were all key factors in PI3K-AKT-mTOR and WNT signaling pathway.
Conclusion
Thus, results supported that STAT1 might be used as a potential therapeutic target meanwhile STAT4 and STAT6 might act as prognostic molecular markers of improved survival for UCEC.
Constitutive formulations for active anisotropy in soft electroelastic materials
Authors: Goulbourne Nakhiah C. , Li Yali 
Published: November 2022

Abstract
Inspired by biology and engineered soft active material systems, we explore constitutive formulations for a soft material consisting of soft contractile fibers embedded in a soft matrix. The mathematical implementation of the model is based on a multi-field invariant formulation within a nonlinear continuum mechanics framework. The model demonstrates an interesting interplay between life-like contractility of the bioinspired fibers and matrix activation. The model could be used to design and inspire the development of new soft material systems that seek to replicate three dimensional biological motion.