bluuebunny/crossref_metadata_2025_split huggingface dataset:
Deuterated Linoleic Acid Attenuates the RBC Storage Lesion in a Mouse Model of Poor RBC Storage
Authors: Kim Christopher Y. , Johnson Hannah , Peltier Sandy , Spitalnik Steven L. , Hod Eldad A. , Francis Richard O. , Hudson Krystalyn E. , Stone Elizabeth F. , Gordy Dominique E. , Fu Xiaoyun , Zimring James C. , Amireault Pascal , Buehler Paul W. , Wilson Robert B. , D’Alessandro Angelo , Shchepinov Mikhail S. , Thomas Tiffany 
Published: April 2022

Background: Long-chain polyunsaturated fatty acids (PUFAs) are important modulators of red blood cell (RBC) rheology. Dietary PUFAs are readily incorporated into the RBC membrane, improving RBC deformability, fluidity, and hydration. However, enriching the lipid membrane with PUFAs increases the potential for peroxidation in oxidative environments (e.g., refrigerated storage), resulting in membrane damage. Substitution of bis-allylic hydrogens with deuterium ions in PUFAs decreases hydrogen abstraction, thereby inhibiting peroxidation. If lipid peroxidation is a causal factor in the RBC storage lesion, incorporation of deuterated linoleic acid (DLA) into the RBC membrane should decrease lipid peroxidation, thereby improving RBC lifespan, deformability, filterability, and post-transfusion recovery (PTR) after cold storage.Study Design and Methods: Mice associated with good (C57BL/6J) and poor (FVB) RBC storage quality received diets containing 11,11-D2-LA Ethyl Ester (1.0 g/100 g diet; deuterated linoleic acid) or non-deuterated LA Ethyl Ester (control) for 8 weeks. Deformability, filterability, lipidomics, and lipid peroxidation markers were evaluated in fresh and stored RBCs.Results: DLA was incorporated into RBC membranes in both mouse strains. DLA diet decreased lipid peroxidation (malondialdehyde) by 25.4 and 31% percent in C57 mice and 12.9 and 79.9% in FVB mice before and after cold storage, respectively. In FVB, but not C57 mice, deformability filterability, and post-transfusion recovery were significantly improved.Discussion: In a mouse model of poor RBC storage, with elevated reactive oxygen species production, DLA attenuated lipid peroxidation and significantly improved RBC storage quality.
Oxygenation Performance of Different Non-Invasive Devices for Treatment of Decompression Illness and Carbon Monoxide Poisoning
Authors: Köhler Andrea , Zoll Felicitas M. , Ploner Thomas , Hammer Alexander , Joannidis Michael , Tilg Herbert , Finkenstedt Armin , Hartig Frank 
Published: April 2022

Study Objective:Application of high concentrations of oxygen to increase oxygen partial pressure (pO2) is the most important treatment for patients with carbon monoxide intoxication or divers with suspected decompression illness. The aim of this study was to evaluate the oxygenation performance of various non-invasive oxygen systems.Methods:The effect of different oxygen systems on arterial pO2, pCO2 and pH and their subjective comfort was evaluated in 30 healthy participants. Eight devices were included: nasal cannula, non-rebreather mask, AirLife Open mask, Flow-Safe II CPAP device, SuperNO2VA nasal PAP device, all operated with 15 L/min constant flow oxygen; nasal high-flow (50 L/min flow, 1.0 FiO2), non-invasive positive pressure ventilation (NPPV, 12 PEEP, 4 ASB, 1.0 FiO2) and a standard diving regulator (operated with pure oxygen).Results:Diving regulator, SuperNO2VA, nasal high-flow and NPPV achieved mean arterial pO2 concentrations between 538 and 556 mm Hg within 5 minutes. The AirLife Open mask, the nasal cannula and the non-rebreather mask achieved concentrations of 348–451 mm Hg and the Flow-Safe II device 270 mm Hg. Except for the AirLife open mask, pCO2 decreased and pH increased with all devices. The highest pH values were observed with NPPV, diving regulator, Flow-Safe II and nasal high-flow but apparent hyperventilation was uncommon. The AirLife Open and the non-rebreather mask were the most comfortable, the SuperNO2VA and the nasal cannula the most uncomfortable devices.Conclusion:A standard diving regulator and the SuperNO2VA device were equally effective in providing highest physiologically possible pO2 as compared to nasal high-flow and NPPV.
Implementation Facilitators and Challenges of a Place-Based Intervention to Reduce Health Disparities in Harlem Through Community Activation and Mobilization
Authors: VanDevanter Nancy , Zhong Lynna , Dannefer Rachel , Manyindo Noel , Walker Sterling , Otero Victor , Smith Kimberly , Keita Rose , Thorpe Lorna , Drackett Elizabeth , Seidl Lois , Brown-Dudley La'Shawn , Earle Katherine , Islam Nadia 
Published: April 2022

BackgroundTo address significant health inequities experienced by residents of public housing in East and Central Harlem compared to other New Yorkers, NYC Department of Health and Mental Health (DOHMH) collaborated with community and academic organizations and the New York City Housing Authority to develop a place-based initiative to address chronic diseases in five housing developments, including a community activation and mobilization component led by community health organizers (CHOs).PurposeGuided by the Consolidated Framework for Implementation Research (CFIR), we evaluated the initial implementation of the community activation and mobilization component to systematically investigate factors that could influence the successful implementation of the intervention.MethodsNineteen in-depth qualitative interviews were conducted with a purposive sample of CHOs, community members and leaders, collaborating agencies and DOHMH staff. Interviews were transcribed verbatim, and themes and codes were developed to identify theoretically important concepts of the CFIR and emergent analytic patterns.ResultsFindings identified important facilitators to implementation: positive community perception of the program, CHO engagement and responsiveness to community needs, CHO norms and values and adaptability of DOHMH and CHOs to community needs. Challenges included the instability of the program in the first year, limited ability to address housing related issues, concerns about long term funding, competing community priorities, low expectations by the community for the program, time and labor intensity to build trust within the community, and the dual roles of CHOs as community advocates and DOHMH employees.ConclusionsFindings will guide future community activation and mobilization activities. The study demonstrates the value of integrating implementation science and health equity frameworks.
Spatio-Temporal Distribution and Demographic Characteristics of Congenital Heart Defects in Guangdong, China, 2016–2020
Authors: Miao Huazhang , Zeng Qinghui , Shi Zengping , Xia Yi , Shi Lushaobo , Chen Dongxue , Guo Pi , Zhu Yingxian , Wang Dong 
Published: April 2022

BackgroundCongenital heart defects are the most common type of birth defects and bring a heavy disease burden in China. Examining the temporal and spatial trends of congenital heart defects epidemics can give some elementary knowledge for succeeding studies.ObjectiveTo characterize the spatial-temporal patterns of the prevalence of congenital heart defects based on a substantial cohort of the perinatal fetus in south China in 2016–2020.MethodsThis study was a retrospective population-based cohort study conducted in Guangdong, China from 2016 to 2020. Pregnant women and their infants received birth defect surveillance during pregnancy and seven days after delivery in more than 1,900 midwifery hospitals in 21 cities. Perinatal infants with congenital heart defects were identified and enrolled. The prevalence of congenital heart defects was calculated according to cities, years, urban and rural areas, regions of Guangdong, categories of maternal age at delivery, seasons of delivery, and infant's gender.ResultsA total of 8,653,206 perinatal infants and 53,912 total congenital heart defects were monitored in Guangdong, including 46,716 (86.65%) without other defects and 7,736 (13.35%) with other defects. The average prevalence of total congenital heart defects was 62.30/10,000 (95% CI, 61.78/10,000–62.83/10,000), congenital heart defects without other defects was 53.36/10,000 (95% CI, 52.88/10,000–53.85/10,000), and congenital heart defects with other defects was 8.94/10,000 (95%CI, 8.74/10,000–9.14/10,000). From 2016 to 2020, the prevalence of total congenital heart defects was 54.92/10,000, 54.23/10,000, 63.79/10,000, 73.11/10,000, 68.20/10,000, respectively. We observed geographical variations within the prevalence of congenital heart defects. The prevalence of congenital heart defects was much higher in the Pearl River Delta region than in the non-Pearl River Delta region, as well as higher in urban areas than in rural areas.ConclusionThe findings of this study are helpful to the understanding of the etiology and epidemiology characteristics of congenital heart defects in south China. Our data likely reflect a better estimate of the spatiotemporal trends in congenital heart defects prevalence than reported previously.
The Evaluation of the Diagnostic Value of a PCR Assay When Compared to a Serologic Micro-Agglutination Test for Canine Leptospirosis
Authors: Martin Elizabeth A. , Heseltine Johanna C. , Creevy Kate E. 
Published: April 2022

ObjectiveTo evaluate PCR assay sensitivity and specificity compared to that of microscopic agglutination test (MAT) for diagnosis of canine leptospirosis. Electronic records search was performed to identify dogs with results for both PCR and MAT testing for leptospirosis.MethodsAll dogs were clinically ill. Diagnosis of leptospirosis was defined as an unvaccinated dog with a positive MAT titer of ≥1:800 or a vaccinated dog or dog with an unknown vaccination status with a positive MAT titer of ≥1:1,600. Diagnosis of leptospirosis was excluded based on MAT titer &lt;1:800 on both the initial and convalescent samples or an initial MAT titer &lt;1:800 and an alternative definitive diagnosis.ResultsForty-nine samples (urine, n = 39; blood, n = 10) were evaluated. Leptospirosis was diagnosed in 17 dogs and excluded in 26 dogs. Urine PCR assay demonstrated sensitivity of 69.2%, specificity of 100%, positive predictive value of 100%, and negative predictive value of 86.6%. Blood PCR assay demonstrated sensitivity of 25%, specificity of 100%, positive predictive value of 100%, and negative predictive value of 25%. Overall PCR sensitivity was 52.4%, specificity was 100%, positive predictive value was 100%, and negative predictive value was 73.7%.ConclusionsPCR assay performed on urine or blood has high specificity and positive predictive value when compared to MAT for diagnosis of clinical canine leptospirosis. Sensitivity and negative predictive value are moderate to low, so PCR testing should be performed in conjunction with paired MAT testing for canine leptospirosis. Prior antibiotic therapy does not preclude the use of the PCR test.
SISTEM PENDUKUNG KEPUTUSAN UNTUK MEMILIH KOMPUTER BERDASARKAN SALAH SATU KEBUTUHAN KONSUMEN DENGAN METODE SIMPLE ADDITIVE WEIGHTING
Authors: Kadek Aditama , Anindia Putra I Nyoman Tri , Iwan Sudipa I Gede , Kartini Ketut Sepdyana 
Published: April 2022

Griya IT merupakan salah satu toko penyedia barang elektronik seperti komputer, laptop, handphone dan lain lain. Saat ini komputer menjadi salah satu sarana yang tidak pernah lepas dari kehidupan sehari-hari seperti mengerjakan pekerjaan kantor, mengerjakan tugas sekolah atau kuliah serta sebagai sarana hiburan. Berkembang pesatnya teknologi komputer membuat banyaknya pilihan yang seringkali membuat konsumen bingung untuk menentukan komputer yang tepat bagi kebutuhan dirinya. Maka dari itu perlu dirancangan sistem pendukung keputusan yang ditunjukan bagi konsumen agar mampu menentukan alternatif prioritas komputer yang di inginkan. Teknik pengambilan data yang digunakan dalam penelitian ini menggunakan teknik observasi, data diambil berdasarkan banyaknya permintaan akan kebutuhan konsumen dalam penggunaan komputer, serta menentukan kriteria-kriteria yang menjadi pertimbangan untuk memilih komputer. Kriteria yang menjadi bahan pertimbangan oleh konsumen yaitu budget yang disiapkan oleh konsumen(C1), garansi dari komputer (C2), spesifikasi dari komputer (C3), dan budget perangkat pendukung. Metode yang digunakan yaitu Simple Addiitive Weighting (SAW) untuk menghasilkan nilai bobot kriteria, skoring nilai budget dan garansi komputer serta perhitungan nilai akhir menggunakan proses normalisasi Cost dan Benefit. Hasil penelitian dalam penerapan metode Simple Addaitive Weighting (SAW) untuk menentukan nilai bobot kriteria dengan tiga alternatif yaitu komputer All In One (AIO), komputer gaming dan komputer design menghasilkan alternatif komputer gaming sebagai alternatif terbaik bagi pelanggan dalam pemilihan komputer dengan bobot sebesar 0,85.
INVOLVEMENT OF TECHNOLOGICAL INNOVATION IN SPORTS
Authors: Zefi Gjulio , Andersons Aigars , Bushati Jozef 
Published: April 2022

INTRODUCTION
The complexity of the tools used in sports requires constant technological change and improvement. In this paper we will highlight how technological innovations have influenced the development of sports.
Is it true that technology has intervened in improving results in all sports?
Many authors (Tidd et al., 1997; Tidd and Bessant, 2009; Hakansson and Snehota, 1995) have attempted to highlight the complex relationships between the innovation process and the incentives that lead to various sport-related inventions.
MATERIALS AND METHODS
In this paper we will use the method of analysis and description to show how technological innovation has influenced the development of sport. The complexity of the tools used in sports constantly requires technological changes and improvements. For example, gymnastics equipment, athletic vaulting poles, tennis rackets, bikes, roller skates and ice skates, etc. are constantly undergoing technological evolution.
We will analyse how innovations such as: the use of rubber suits in swimming (2008), the increase in cycling speed by the invention of the mechanism that regulates the ratio of wheel speed (1935) or the use of light rubber and very resilient marathon running shoes (2013) have improved results, helping to achieve times at the maximum limits of human ability.
RESULTS
Comparing the results drawn from the analysis of scientific works of different authors gives us the opportunity to reach conclusions, which open new avenues of perspective in the sports sector in terms of the design and implementation of technology. The inclusion of technology in sports gives human society greater opportunities to reap its benefits for a more active life.
DISCUSSION
Data provided by various authors show that: the use of rubber suits in swimming (2008), increasing the speed in cycling by inventing the mechanism that regulates the ratio of wheel speed (1935) or the use of rubber lightweight and very resilient marathon running shoes (2013) have improved results, helping to achieve times at the maximum limits of human ability.
In order for innovation to have the greatest impact on sports, cooperation and exchange of experiences is required between sports companies and large manufacturers of sports equipment in improving the technical aspects of the equipment they produce.
CONCLUSIONS
The involvement of innovation and technology at different levels have has unquestionably influenced the discovery of high-tech materials as well as the modification and improvement of various techniques. Consequently, these inclusions have made sports performance achieve unimaginable results, pushing the limits of human ability.
THE BLUE FLAG PROGRAMME AND DESTINATION IMAGE: A STUDY ON EDEN BEACH, PUDUCHERRY, INDIA
Authors: V Sivakami , Raghu Ankathi , P Raja 
Published: April 2022

INTRODUCTION
Beach tourism offers enormous economic benefits to local communities and also causes many environmental and social impacts on the coastal environment. Many people choose to take a holiday at a beach destination because they want to relax, escape and participate in beachfront recreation (Lucrezi and Vander Walt, 2016). India, with a coastline of 7516.6 km (Centre for coastal zone management and coastal shelter belt, 2017), has a wide variety of beaches on its shoreline that offer recreational activities to tourists. Foundation for Environment Education in Denmark (FEE) has awarded Blue Flag Certification to two new beaches in the year of 2021, namely Kovalam in Tamil Nadu and Eden beach in Puducherry, India. A Blue Flag beach is an eco-tourism model that aims to offer tourists clean and sanitary bathing water, facilities/amenities, and a safe and healthy environment while providing sustainable development to the local community. Around the globe, only 47 countries have achieved this blue flag certification for its beaches.
MATERIALS AND METHODS
The researchers have studied the destination image of Puducherry as a beach tourism destination, with special reference to Eden beach, Puducherry. With the support of literature studies, the assumption that a positive destination image also promotes the intention of tourists to revisit, thus bringing sustainable development to the destination, is justified.
RESULTS
The results are theoretical. The study is based on Eden beach, Puducherry. The results show that the destination image encourages the intention of tourists to revisit and loyalty to the destination. This research is significant for the future as it helps to propagate India’s image as a clean and green beach tourism destination, thus creating a positive destination image among domestic and international travellers.
DISCUSSION
On achieving this Blue flag certification, the destination image of Pondicherry as a beach destination, a union territory in India, creates loyalty to destination that encourages the intention to revisit the destination among tourists that ultimately benefits the stake holders of the destination and helps in achieving sustainable development.
CONCLUSIONS
The connection between the destination image, destination loyalty and intention to revisit is clear and proven in many other research findings. Therefore, future researchers can also focus on other beaches in India with Blue flag certification and their role in promoting tourism in that region, as well as the image of a tourist destination and the tourist's perception of a tourist destination on other blue flag beaches of India.
BUSINESS INCUBATION SCENE IN THE PANDEMIC THROUGH AN OPEN INNOVATION APPROACH – LATVIA CASE STUDY
Authors: Cīrule Iveta 
Published: April 2022

INTRODUCTION
The concept of Open Innovation (OI) is recognised by researchers and practitioners internationally, but research on business incubation and incubators as OI partners promoting co-creation, collaboration, co-petition is missing the explanation of how OI in a pandemic transforms business incubation. Business incubators (BIs) are defined as a tool “to help small start-ups overcome liabilities of newness and smallness” (Vanderstraeten et al.,2020). The research aims to investigate the actual business incubation situation in Latvia in the pandemic with the focus on the OI approach. What is the business incubation scene in a pandemic? This remains the research question, addressing the hypothesis - the pandemic facilitated changes in national incubation promoting online co-creation, co-petition and collaboration.
MATERIALS AND METHODS
The Latvian business incubation scene was the main research field of the postdoctoral research project “Open Innovation”. Descriptive analyses of various incubator types in Latvia were performed, identifying the types of incubators including the University, industry and state-run incubators, incubation services and requirements. The content analyses of the co-occurrence of key services were conducted by mapping the incubation service area. The research period was during the pandemic time of 2021, when several socialisation restrictions came into force in Latvia, thus, shifting incubation online.
RESULTS
The pandemic facilitated changes in the national incubation system, promoting online co-creation, co-petition and collaboration in the business incubation field offering online nature services to tenants. External online expertise, as well as online mentoring support, were the OI outside-in strategy activities offered to tenants.
DISCUSSION
The incubation requirements regarding tenants’ recruitment still differ in Latvia, offering the incubation from the idea stage to real time performance, and work in business incubators was on-going even in the pandemic. The nature of services switched to on-line and distance incubation, addressing the basic needs of tenants. The future research could focus on the further elaboration of measurement between the impact of on-site and on-line services on tenants’ performance.
CONCLUSION
The description of the national incubation scene during the pandemic is both a theoretical and practical novelty of this research, as this was the first time in the Latvia business incubation field when on-site services were restricted due to the pandemic. This research proved the importance of the business incubation function in entrepreneurship support and the ability of incubators to provide this function on-line.
PENGETAHUAN BIDAN DALAM PELAYANAN ANTENATALCARE DI MASA PANDEMI COVID 19
Authors: Yusnidar Yusnidar Yusnidar 
Published: April 2022

Ibu hamil adalah salah satu kategori yang rentan terkena virus seperti di masa pandemic virus Covid 19. Bidan dalam melakukan pemeriksaan antenatalcare harus sesuai standar pelaksanaan selama masa pandemi karena Ibu hamil adalah salah satu kategori yang rentan terkena virus seperti di masa pandemic virus Covid 19. Penelitian ini bertujuan untuk mengidentifikasi pengetahuan bidan dalam standar pelayanan antenatalcare di masa pandemi Covid 19. Metode penelitian ini metode survey dengan desain yaitu cross sectional. Sampel dalam penelitian ini adalah bidan yang aktif memberikan pelayanan ANC di BPM kota Palopo yang berjumlah 30 orang. Pengumpulan data melalui online dengan cara menyebar link kuesioner. Hasil penelitian didapatkan sebanyak 70% bidan yang memiliki pengetahuan baik namun tidak menerapkan protokol dalam melaksanakan pelayanan antenatalcare. Hasil analisi menunjukkan bahwa tidak ada hubungan antara pengetahuan dengan pelayanan antenatalare. Kesimpulan menunjukkan bahwa pengetahuan yang baik, tidak menjamin dapat melaksanakan pelayanan ANC sesuai standar di masa pandemic covid 19.
UJI LABORATORIUM PADA DENDENG JANTUNG PISANG BATU (MUSA PARADISIACAL L) SEBAGAI PENINGKATAN ASI PADA IBU MENYUSUI
Authors: Fitri Nina , Sari Vitria Komala , Roza Nelvia 
Published: April 2022

Menurut provinsi, cakupan ASI pada bayi sampai usia 6 bulan paling rendah berada di Sumatera Utara sebesar 12,4%, Gorontalo sebesar 12,5% dan paling tinggi di DI Yogyakarta sebesar 55,4%. Sementara kondisi Sumatera Barat di dapatkan pemberian ASI sampai usia 6 bulan sebesar 37,6% Tujuan adalah Untuk mengetahui hasil laboratorium dendeng jantung pisang batu Terhadap peningkatan ASI pada Ibu menyusui Tahun 2021. Jenis penelitian adalah Jenis penelitian ini adalah quasi eksperimental dengan desain pretest. Sampel adalah dendeng jantung pisang. Penelitian ini dilakukan di balai riset obat dan makanan laboraorium kota jambi. Hasil didapatkan bahwa kandungan flavonoid di senyawa kimia yang paling tinggi pada dendeng jantung pisang yaitu 1,360mg/g sedangkan pada senyawa lainnya alkaloid 0,790mg/g, felifenol 0,482mg/g, antioksidan 0,051mg/g .dan hasil analisis ekstrak terdapat ekstrak pada jantung pisang yaitu N-heksan, etil asetat dan etanol . dari ketika ekstrak tersebut terdapat satu ekstrak yang banyak mempengaruhi peningkatan produksi ASI yaitu etanol. Disimpulkan bahwa masih adanya kandungan jantung pisang batu untuk meningkatkan produksi ASI setelah diolah menjadi makanan rumahan yang terdapat didalam jantung pisang adalah kandungan laktagongum yang terdiri dari flovanoid 1,360mg/g, felifenol 0,482mg/g , senyawa tersebut yang bekerja pada kandungan oksitosi dan prolaktin yang gunanya untuk meningkatkan produksi ASI pada ibu menyusui.