bluuebunny/crossref_metadata_2025_split huggingface dataset:
Isolated Third Cranial Nerve Palsy: Aetiology - Clinical Profile and Recovery at a Tertiary Neuro-ophthalmology Centre on the East Coast Peninsular of Malaysia
Authors: Nurul-Ain Masnon , Wan Hitam Wan Hazabbah , Shatriah Ismail , Abdul Halim Sanihah 
Published: October 2022

Objective: This study aimed to study the aetiologies, clinical profile and recovery of isolated third cranial nerve palsy (ITCNP) patients, at a tertiary neuro-ophthalmology center on the East Coast Peninsular of Malaysia. Material and Methods: This was a retrospective study, involving 33 patients with newly diagnosed ITCNP, who were treated at the Hospital of the Universiti Sains, Malaysia; from January 2018 to December 2019, with a follow up period ranging from 18 to 24 months. The demographic data, clinical features and aetiologies of the patients were analysed. Results: Patients’ ages ranged from 14 to 79 years (mean: 48, 50 years of age). The main aetiology was microvascular ischemia (39.4%), followed by trauma (30.3%), aneurysm (15.2%), tumour (9.1%) and undetermined cause (6.1%). Neuroimaging was performed for those indicated cases; with either computed tomography (CT), CT angiography, digital subtraction angiography, magnetic resonance imaging (MRI) with contrast or MRI angiography. Two-thirds of the patients (66.7%) had periorbital pain, which included 30.8% of patients with microvascular ischemia and 60.6% had pupil involvement; which was also found in 23.1% of patients with microvascular ischemia. Complete external third nerve palsy occurred in 18.2% of patients, and aberrant regeneration was observed in 36.4% of patients. Complete recovery occurred in 48.5%, of all patients, having microvascular ischemia and undetermined causes. Conclusion: The aetiologies, clinical profile and recovery of ITCNP patients in our institution are comparable to those reported in other previous studies. Patients with microvascular ischemia may also demonstrate periorbital pain and anisocoria. Neuroimaging remains the gold standard and the best tool via which to exclude other sinister and lifethreatening aetiologies.
Double Moving Average Control Chart for Autocorrelated Data
Authors: Arooj Hira , Malik Khawar Iqbal 
Published: October 2022

The assumption of normality and independence is necessary for statistical inference of control charts. Misleading results are obtained if the traditional control chart technique is applied on the auto-correlated data. When data is correlated, a time series model is employed to produce an optimum output. The objective is to create a new control chart methodology that takes the autocorrelation of observations into account. Charts of Moving Average, Exponentially Weighted and Cumulative Sum better perform in the existence of autocorrelation data for small and moderate changes. The proposed methodology is highly skilled and receptive to minor, moderate and major changes in the process. Propsed DMA chart increases efficiency of average run length (ARL) chart for moving average (MA) to detect the small to medium magnitude shifts in the mean. The simulation also demonstrates that the DMA chart with spans of w=10 and 15 generally performs well in terms of average run length (ARL) as compared to clasical MA. This research may be extended to a multivariate autocorrelated statistical process control, but it can also be used to recognise and categorise seven categories of traditional control chart patterns, such as Downward, Upward Shift, Normal Trend, Cyclic, Systematic patterns, Increasing and Decresing Trend. In order to identify and categorize a set of subclasses of abnormal patterns, this model (multivariate autocorrelated statistical process control chart) should employ a multilayer feed forward Artificial Neural Network (ANN) architecture controlled by a back-propagation learning rule.
Sources and Chemistry of Flavonoids; their Biological and Therapeutic Potential
Authors: Hussain Dr Shabbir , Waqar Mirza  , Murtaza Mufliha , Nazir Ansa , Hanif Iram , Ahmad Muhammad 
Published: October 2022

Flavonoids are natural polyphenolic compounds, which are responsible for the taste and colors of medicinal plants, herbs, fruits, vegetables. Fruits (e.g., Berries, cherries, plums, apples, lemons, oranges, and grapes etc) and vegetables (e.g., broad beans, olives, onions, spinach, shallot etc) are the main sources of flavonoids. They also exist abundantly in cocoa products, black and green tea, red wine, red pepper, chamomile, celery, parsley, ginkgo, and mint. Flavonoids derivatives can also be synthesized through esterification, halogenation, alkoxylation, alkylation, aromatic hydroxylation, acylation and conjugation with various organic compounds. Flavonoids can be supplemented in a staple of food as nutraceutical agents and have an important role in human diet. They possess diverse biological activities including anti-inflammation, anti-oxidation, anti-cancer, anti-diabetes, anti-obesity, antimutagenic, neuroprotective and also have beneficial effects on oxidative stress, inflammation, insulin resistance, lipid metabolism and neurodegenerative diseases (e.g., amyotrophic lateral sclerosis, Huntington’s disease, Parkinson’s disease and Alzheimer’s disease). Flavonoids contain a 15-carbon skeleton; the basic structure consists of a flavan nucleus, a combination of two benzene and one pyran rings. Flavonoids are divided into eight important groups i.e., flavones, flavanols, isoflavones, flavan-3-ols, flavanonols, anthocyanidins, chalcones, and flavanones. A structure-activity relationship exists between flavonoids and their antioxidant activities. Flavonoids are effective in chelating metal ions and scavenging free radicals. The antioxidant properties of flavonoids are governed by their –OH groups, differences in hydrophobicity and molecular planarity.
Translation and Validation of the Filipino Version of the University of Washington Quality of Life Questionnaire (UW-QOL) for Patients with Head and Neck Cancer
Authors: Dominguez Josalline , Dominguez Elpidio Jesus 
Published: October 2022

ABSTRACT

Objective: To translate the University of Washington Quality of Life (UW-QOL) questionnaire into Filipino and to validate it among a sample of patients with head and neck cancer.

Methods:
Design: Cross-sectional study
Setting: Tertiary Government Training Hospital
Participants: 33 patients

Results: A total of 33 patients were recruited in this study. Eighteen (54.5%) were male, and 15 (45.5%) were female aged 24-79 years old (mean age 52.85 ± 11.81 years old) completed the study. All items in the Filipino translation of the UW-QOL had a content validity index. The raters in face validation had 100% agreement in almost all items except for the appropriateness of font size and space of the questionnaire. The Cronbach’s alpha of the Filipino version of the questionnaire was 0.8596. The alpha score when each of the items was deleted remained within the range of 0.83 – 0.86. The intraclass correlation coefficients of all items were greater than 0.9. For all items, there were no significant difference observed between the test and retest scores.
Conclusion: This study showed that the Filipino translation of the UW-QOL is culturally adapted, internally consistent and stable. It is as reliable as the original English version in assessing health related QOL, and valid for assessing HR-QOL among patients with head and neck cancers.
Effect of Proton Pump Inhibitors on Reflux Symptom Index (RSI) and Reflux Finding Score (RFS) in Patients with Laryngopharyngeal Reflux: A Systematic Review and Meta-Analysis
Authors: Soriano Patricia Ann , Llanes Erasmo Gonzalo , Dela Cruz Anna Pamela , Mendoza Kevin Michael 
Published: October 2022

ABSTRACT

Objectives: The purpose of this study was to determine the efficacy of proton pump inhibitor (PPI) therapy in treating the symptoms and laryngeal findings of laryngopharyngeal reflux (LPR).
Methods: Placebo-controlled, randomized clinical trials published after June 2001 to January 2021 which used PPI as the sole intervention and the RSI or RFS as outcome measures were eligible for inclusion. Studies that were published prior to June 2001, those which only made use of questionnaires other than the RSI or RFS, those which used PPI in combination with other treatments, or those with unavailable full-text manuscripts were excluded. These studies were identified from MEDLINE, Scopus, Cochrane Library, Embase, and HERDIN Plus databases which were searched from May 21 to 26, 2020. The primary outcome was the mean difference between baseline/pre-treatment and post-treatment RSI scores for both PPI and placebo groups. The secondary outcome was the mean difference between pre-treatment and post-treatment RFS scores for PPI and placebo groups. Aggregate results of these outcomes were analyzed using forest plots. Heterogeneity was determined through prediction intervals. Risk of bias of individual studies was assessed using the Cochrane Collaboration’s Tool in Assessing Risk of Bias.

Results: Nine randomized control trials were included with a total of 737 patients randomized and 595 patients analyzed – 294 from the PPI group and 301 from the placebo group. There were notable variations among the studies in terms of choice of PPI, dosage and frequency. Out of nine studies, four used both RSI and RFS in their analysis. Two studies used RSI alone and three used the RFS in combination with symptom questionnaires other than the RSI. There was a significant decrease in the RSI of the PPI group versus the placebo group with a mean difference of -2.83 (95% CI, -5.13 to -0.53, p = .02). However, there was no significant decrease in the RFS between PPI and placebo groups with a mean difference of -0.84 (95% CI, -2.66 to 0.98, p = .37). For two clinical trials which only reported post-treatment RFS, there was also no significant difference between the two treatment groups with a mean difference of 1.27 (95% CI, -0.22 to 2.76, p = .10).
Conclusion: This meta-analysis found that, although a statistically significant benefit in RSI was noted with PPI therapy, this difference may not translate to a clinically significant change in symptoms; therefore, there is insufficient evidence to recommend for or against the treatment of LPR with PPIs.
Ketidakadilan Pembayaran PPN Terhadap Penjualan Kredit Ditinjau Dari Undang-undang No 42 Tahun 2009
Authors: Soewita Samuel 
Published: October 2022

Dalam rangka pembangunan nasional yang berkesinambungan, pajak merupakan salah satu sumber pendapatan bagi negara. Dengan dberlakukannya Undang-Undang PPN, maka seluruh penjualan barang dan jasa yang ditetapkan untuk dikenakan pajak pertambahan nilai. Pajak Pertambahan Nilai merupakan pajak yang dikenakan kepada pihak konsumen atau pengguna akhir. Pengusaha Kena Pajak (PKP) harus menyetorkan ke kas negara paling lambat akhir bulan berikut sebelum pelaporan PPN. Penyetoran PPN tetap harus dilakukan apabila Pengusaha Kena Pajak (PKP) melakukan penjualan kredit 3 bulan, maka PPN harus ditanggung atau ditalangi oleh Pengusaha Kena Pajak. Metode penelitian yang digunakan adalah Yuridis Sosiologis, dengan menggunakan Data Primer dan Data Sekunder, dengan analisis secara deskripsi kualitatif. Ketidakadilan ini timbul karena adanya pasal yang mengikat pada UUPPN No 42 Tahun 2009 pasal 15 A. Diperlukan perubahan pasal 15 A UU PPN No 42 tahun 2009 agar terjadi keadilan pemungutan pajak.
Dasar-Dasar Penerapan Good Governance Dalam Pengurusan Izin Mendirikan Bangunan Dihubungkan Dengan Peraturan Daerah Kota Tangerang Selatan No. 14 Tahun 2011 Tentang Penerbitan Izin Mendirikan Banguan (IMB) dan Peraturan Daerah No. 15 Tahun 2011 Tentang Tata Ruang Wilayah Kota Tangerang Selatan
Authors: Susilowati Asih 
Published: October 2022

Para pelaku dan politisi di daerah perlu menyadari bahwa keberadaannya dipercaya untuk kurun waktu tertentu, sehingga perlu adanya kejelasan, fokus dan realistis. Jadwal acara. Penelitian ini merupakan analisis deskriptif dengan metode hukum social/sosiologis yuridis. Alat pengumpulan data melalui wawancara. Mendapatkan data dan melakukan analisis kualitatif. Ternyata ini adalah proses atau prosedur untuk mendapatkan izin dan otorisasi Tata Kota dan Tata Kota Tangerang Selatan. Kualitas pelayanan publik terkait dengan pemeliharaan IMB di Tangerang Selatan terkait dengan SPM, namun karena berbagai alasan termasuk cacat, mungkin tidak dapat diimplementasikan dengan baik Kualitas sumber daya manusia, sarana dan prasarana, pelayanan birokrasi dan partisipasi masyarakat sangat rendah. Atas dasar ,dasar-dasar tata kelola yang baik yang ada, penerapan dasar-dasar tata kelola yang baik dalam pengelolaan IMB Tangerang Selatan tidak dapat sepenuhnya diterapkan, misalnya prinsip partisipasi tidak dapat sepenuhnya diterapkan, dan prinsip tata kelola yang baik tidak dapat diterapkan secara optimal. . Penerapan dasar-dasar good governance dalam pengelolaan IMB di Tangerang Selatan belum terlaksana secara optimal.
Dilema Hak Asasi Manusia dan Hukum Mati Dalam Konstitusi Indonesia
Authors: Heltaji Herliana 
Published: October 2022

Hukuman mati merupakan hukuman yang masih diakui penerapannya di Indonesia. Hukuman mati biasanya diterapkan untuk para pelaku kejahatan tertentu yang mana kejahatan tersebut termasuk dalam kategori kejahatan luar biasa (extra ordinary crimes). Kepastian hukum terkait hukuman mati ini dapat dilihat pada Pasal 10 huruf a Kitab Undang-Undang Hukum Pidana (KUHP), menjelaskan bahwa hukuman pidana mati merupakan salah satu hukuman pokok. Pada saat yang bersamaan, pasal 28A Undang-Undang Dasar 1945 menjelaskan “setiap orang berhak untuk hidup serta berhak mempertahankan hidup dan kehidupannya”. Selain itu pada pasal 28I ayat (1) Undang-Undang Dasar 1945 juga menegaskan bahwa “Hak untuk hidup adalah hak asasi manusia yang tidak dapat dikurangi dalam keadaan apapun”. Bahkan Kovenan Internasional, yaitu Declaration Universal of Human Right (DUHAM) pada pasal 3 menegaskan bahwa, “Setiap orang berhak atas kehidupan, kebebasan dan keselamatan sebagai induvidu.”. Bahwa penelitian ini adalah penelitian normatif. Permasalahan yang akan dibahas oleh penulis adalah; 1) Apakah hukuman mati melanggar Hak Asasi Manusia? Dapat disimpulkan hukuman mati sebagai hukuman pidana merupakan pelanggaran Hak Asasi Manusia (HAM) yang mana bertentangan dengan konstitusi negara Undang-Undang Dasar 1945 dan kovenan internasional.
Long-term response planting method on wheat under conservation agriculture
Authors: Escobosa-García María Isabel , Soto-Ortiz Roberto , OROZCO RIEZGO CARLOS , ESCOBOZA GARCIA LUIS FERNANDO , RUELAS-ISLAS JESUS DEL ROSARIO , RUIZ-ESPINOZA FRANCISCO HIGINIO , NUNEZ-RAMIREZ FIDEL 
Published: October 2022

Objective: To compare different bed planting systems: narrow beds (80 cm), wide beds (100 cm), and flat soil, on the growth and yield of wheat under conservation system.
Design/methodology/approach: Treatments were established on a complete block design with three replicates; also, wheat crop was grown during five seasons. Treatments were as follow: A) wide beds (furrows at 100 cm), B) narrow beds (furrows at 80 cm) and C) flat soil. Response variables were dry weight of 50 stems, weight of 1000 grains, number of spikes (m2), harvest index and yield. Also, the relationship between relative yield and cold units and degree-days were measured.
Results: Flat soil reach the highest dry weight of 50 stems, whereas narrow beds had the maximum number of spikes per m2. Yield was equal between flat soil and narrow beds. No differences were found in the harvest index (HI) among the evaluated treatments. When comparing results between years, dry weight of 50 stems increased and the HI index decreased, affecting negatively the yield. A negative association was found between chill hours and yield.
Findings/conclusions: Despite yield was equal between flat soil and narrow beds, reduction on yields was mainly associated with of reduction in chill hours occurring in each season.
RASIO LINGKAR PINGGANG PINGGUL (RLPP) DAN STATUS HIPERTENSI LANSIA
Authors: Nando Wangi , Kamsiah Kamsiah , Yuliantini Emy 
Published: October 2022

Hipertensi adalah peningkatan tekanan darah sistolikatau diastolik yang tidak normal. Hipertensi merupakan salah satu penyakit degeneratif yang sering terjadi pada kelompok lansia. Faktor- faktor yang mempengaruhi hipertensi pada lanjut usia yaitu jenis kelamin, usia, riwayat keluarga, kebiasaan olahraga, kebiasaan merokok, kebiasaan minum kopi dan obesitas. Penelitian ini bertujuan untuk mengetahui gambaran rlpp dan status hipertensi lansia di posbindu wilayah kerja Puskesmas Nusa Indah Kota Bengkulu Tahun 2019. Penelitian ini menggunakan jenis penelitian Deskriptif Observasional. Teknik yang digunakan adalah Purvosive Sampling dengan jumlah sampel 75 lansia. Analisis statistik yang digunakan adalah analisis univariat yang akan diketahui gambaran distribusi dan frekuensi setiap variabel. Penelitian ini menunjukkan sebagian besar berjenis kelamin perempuan (64%), Sebagian besar berada pada kelompok lansia 60-74 tahun (37,3%), berpendidikan rendah (50,7%), tidak bekerja (62,7%) dengan rlpp tidak normal. Berdasarkan status hipertensi sebagian besar perempuan (54,7%), sebagian besar Lansia (30,7%), berpendidikan rendah (41,3%), tidak bekerja (54,7%), mempunyai riwayat keluarga (65,3%), tidak pernah olahraga (49,3%), dan merokok (88%), serta sering minum kopi (45,3%) memiliki hipertensi kategori ringan. Kesimpulan dari penelitian ini adalah sebagain besar perempuan dengan kelompok umur lansia, berpendidikan rendah, tidak bekerja, ada riwayat keluarga, tidak pernah olahraga dan merokok, serta sering minum kopi memiliki rlpp tidak normal dan status hipertensi kategori ringan. Memperhatikan pola hidup sehat dan aktif dalam kegiatan Posbindu dengan memeriksakan rlpp dan tekanan darah secara berkala. Untuk peneliti selanjutnya, dapat meneliti hubungan variabel penelitian yang sejenis dengan menambah variabel asupan makanan
Microstructure and Corrosion Properties of Austenitic and Duplex Stainless Steel Dissimilar Joints
Authors: Varbai Balázs , Bolyhos Patrik , Kemény Dávid Miklós , Májlinger Kornél 
Published: October 2022

In several applications duplex stainless steels should be joint welded to conventional austenitic stainless steels. In this research LDX 2101 lean duplex stainless steel sheets were welded to conventional 304 austenitic stainless steels, using gas tungsten arc welding. For the welded joints three different welding rods were used: ER 308L, ER 309LSi, and ER 2209. For gas shielding two different shielding gases were used: argon and argon +2% nitrogen. It was found that the nitrogen addition to the shielding gas promoted austenite formation in the weld metal. It was also found Schaeffler-diagram modified by Outokumpu showed a very good estimation to the ferrite content and chemical composition of the weld metal. The ferrite content estimated by the Outokumpu-diagram, showed a close correlation to measured ferrite contents, the highest error was 30%. In case of the chemical composition of the weld metal, the Cr- and Ni-contents were estimated with a maximum of 15% error. In terms of the corrosion resistance, the best pitting corrosion resistance was achieved using the 308L welding rod with argon shielding gas, where the weight loss was 1.6% after the 24 hours immersion test.
Gamificación para fomentar la lectoescritura en niños de tercer año de básica
Authors: Brito Molina Sandra Alejandrina , Guevara Vizcaíno Claudio Fernando , Castro Salazar Ana Zulema 
Published: October 2022

La gamificación como herramienta educativa que garantiza un mayor atractivo en el proceso de aprendizaje a través de dinámicas formativas que combinan lo lúdico y cognitivo lográndose de esta forma un interés sistemático por el contenido brinda una amplia gama de oportunidades con la flexibilidad, adaptabilidad necesaria para ser combinada con otras metodologías de enseñanza lo cual permite un aprendizaje activo que puede manifestarse de manera individual o en equipo con un elevado nivel de competitividad. La gamificación involucra diversas actividades de forma divertida técnica basada en elementos que hace que los juegos sean atractivos, permite a los educandos participar en un entorno donde el aprendizaje sistemático, se basa en una estrategia metodológica que permite un ambiente lúdico que fomente la motivación, la participación y la diversión. El diseño del entorno debe permitir que el alumno partícipe, tome decisiones, asuma nuevos retos, es el uso de estrategias, modelos, dinámicas, mecánicas y elementos propios de los juegos en contextos ajenos a éstos, con el propósito de transmitir un mensaje o unos contenidos o de cambiar un comportamiento, a través de una experiencia lúdica que propicie la motivación reconozca sus logros y al mismo tiempo lograr los objetivos del proceso educativo en la lectoescritura.
Gamificación para fortalecer la lectura comprensiva en niños de diez años
Authors: Chuqui Tandazo Rosa Matilde , García Herrera Darwin Gabriel , Erazo Álvarez Juan Carlos 
Published: October 2022

En la presente investigación se empleó el entono virtual Genially como alternativa de la Gamificación para fortalecer la comprensión lectora en los estudiantes del quinto año de educación básica de la escuela Fiscomisional “Amalia Urigüe” del cantón Déleg de la provincia del Cañar. Para el desarrollo del trabajo se inició con la elaboración de una lectura cuyo contenido fue relacionado con el entorno en la que residen y un cuestionario evaluativo según la escala de Likert, formada por con cinco variables cuantitativos; esto ayudó a conocer las destrezas y habilidades que tiene cada estudiante para decodificar su contenido que es el sustento para obtener la línea base de la información. Seguidamente se implementó metodologías lúdicas, conocidas como gamificación, haciendo uso de los recursos tecnológicos como Genially, para fortalecer la lectura comprensiva. Finalmente se entregó por segunda ocasión la lectura para su interpretación y ejecución de la evaluación correspondiente, consiguiendo dos resultados para el respectivo análisis. Para conocer los cambios producidos con la implementación del experimento, los dos resultados obtenidos fueron introducidos en el software de paquete estadístico para las ciencias sociales SPSS, con los que se determinó que la relación media entre la prueba pretest y postest son asociativas, porque su sig. bilateral es inferior al 0,05, demostrando que los resultados son significativos, es decir, que para fortalecer la comprensión de una lectura se puede emplear la enseñanza por medio de juegos, que se conoce como gamificación, así como también hacer uso de medios virtuales disponibles, como en este caso Genially que permitió relacionar estos dos métodos de enseñanza.