bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pengembangan Instrumen Penilaian Keterampilan Proses Berbasis Sains Pada Materi Sistem Indra
Authors: Sholihah Fatikhatun Nikmatus , Wulandari Anggun , Hidayah Wahyu Nurul 
Published: May 2022

Science based process skills are those that involve the use of tools and materials and interact in learning activities. The research was back to back by needs analysis questionnaire that science teacher and biology teacher never did a skill assessment but not yet applied a science based process skill assessment and the science teacher has applied science but hasn’t practice. The research aims to describe the feasibility of a science based process assessment instrument on the material of the sensory system developed. This development has been using the 4D model namely Define, Design, Develop, Disseminate. but at this stage of disseminate of cost limitations and time. The data collection instruments used included a questionnaire on the needs of educators, an expert validation questionnaire and an expert validation questionnaire. The results of the expert validation of the assessment instrument obtained a percentage of the feasibility of the science based process skills assessment instrument is 72.72% with feasible criteria, and the results of the material expert’s validation percentage of eligibility is 93.75% with worth it criteria. The research conclusion describes the feasibility of a science based process assessment instrument on the developed sensory system material that is worthy of use.
Levantamento dos casos de leishmaniose visceral no município de Caruaru – PE de 2012 a 2020
Authors: Silva Leonardo Souza e , Santos José Naylson Gomes , Silva Aldair de Lima , Soares Efraim Naftali Lopes 
Published: May 2022

Objetivo: Realizar o levantamento do perfil epidemiológico da LVH no período de 2012 a 2020 no município de Caruaru-PE. Metodologia: Os dados foram obtidos na base do Sistema de Informação de Notificação e Agravos. Após essa etapa, os dados receberam tratamento estatístico, onde foram construídos gráficos e tabelas por meio do software excel @2010, o mesmo foi usado para realização dos cálculos para dar maior precisão dos resultados obtidos. Resultados: Foram confirmados 43 casos de LVH. A maior incidência ocorreu no ano de 2015 com 2,6%, a área de residência que apresentou a maior frequência foi a urbana com 63%, a faixa etária mais acometida foi a de 1 a 4 anos com 32,6% e a raça/cor parda apresentou 69,8% dos casos. No que se refere a evolução dos pacientes como LVH, 79,1% foi relacionado a cura. Conclusão: Diante dos dados analisados é necessário que as ações de controle da LVH sejam intensificadas, a identificação dos casos aconteça em tempo oportuno, bem como, o diagnóstico e a assistência ao paciente.
Internamento domiciliar via SUS no Brasil, o impacto do programa “Melhor em Casa”
Authors: Gabardo Jhony Marcelo Bogado , Castilho Matheus Jacometo Coelho de , Bernardineli Ademilson José , Schuroff Hana Paula , Pujals Constanza , Carvalho Maria Dalva de Barros , Pelloso Sandra Marisa , Pedroso Raíssa Bocchi 
Published: May 2022

Introdução: A população brasileira passa por intenso envelhecimento e consequente aumento de multimorbidade impactando os serviços de saúde. Em 2011 o Ministério da Saúde criou o programa “Melhor em Casa” com o intuito de promover o internamento domiciliar como possibilidade de expandir leitos hospitalares ao domicílio do cliente e assim, humanizar o atendimento e diminuir custos. Objetivos: Analisar internamentos domiciliares do Sistema Único de Saúde (SUS) no período de 2008-2019 e correlacionar com custo de internação, variáveis clínicas e epidemiológicas. Método: Estudo quantitativo baseado em dados do Sistema de Internação Hospitalar do Sistema Único de Saúde (SIH/SUS) no período de 2008 a 2019, disponíveis na plataforma eletrônica do Departamento de Informática do SUS (DATASUS). Para análise de tendência foi utilizado o teste de Mann-Kendall e para análise do efeito de intervenção foram ajustados modelos ARIMA, considerando os dados de 2008-2011 sem intervenção e de 2012-2019 com intervenção. Resultados: Houve tendência crescente no número de internamentos domiciliar de 2008 a 2019 ( =0,152 e p=0,537), assim como do custo médio por internamento ( =0,061 e p=0,837) e do sexo feminino sobre o masculino ( =0,606 e p =0,007). Houve tendência decrescente da média de dias por internamento ( =-0,576 e p=0,011) e da taxa de mortalidade ( =0,212 e p=0,373). Conclusão: com custo inferior a 10% do valor diário de um internamento hospitalar, a atenção domiciliar diminui mortalidade e média de dias de internamento. Portanto, com o envelhecimento populacional, programas de internamento domiciliar como o “Melhor em Casa” tornam-se fundamentais.
Correlação entre indicadores bioquímicos, eficiência da hemodiálise e estado nutricional de pacientes renais crônicos
Authors: Carvalho Giovana Alves , Tavares Gessica Fortes , Souza Adriane Fonseca de , Ataíde Bruno Rafael Batista de , Guterres Aldair da Silva 
Published: May 2022

Pacientes com doença renal crônica frequentemente possuem comprometimento do estado nutricional e este fator pode interferir na qualidade do tratamento, favorecendo um pior prognóstico. O objetivo do trabalho foi associar os indicadores bioquímicos, eficiência dialítica e estado nutricional de indivíduos com doença renal crônica em hemodiálise. Estudo descritivo e transversal, com amostragem por conveniência, realizado com pacientes do Centro de Hemodiálise Monteiro Leite em Belém do Pará. As variáveis pesquisadas foram índice de massa corporal, avaliação bioquímica (níveis séricos de albumina, hemoglobina, ureia, fósforo, potássio e glicose) e índices de eficiência dialítica (Kt/V e % de redução de ureia). Os dados foram tabulados e analisados pelo programa Bioestat versão 5.0. Para análise estatística foi aplicado o teste de correlação de Spearman, utilizando p<0.05. Participaram do estudo 72 pacientes, na faixa etária de 19 a 79 anos, sendo 50 (69,4%) do sexo masculino. Dentre esses, 33 (45,8%) apresentavam eutrofia conforme o IMC. Quanto aos parâmetros bioquímicos, a maioria encontrava-se adequada em relação ao ponto de corte da albumina, porém os demais parâmetros expressaram mensuração alterada. Os índices dialíticos demonstraram que a maioria da população recebe tratamento adequado. A correlação entre as variáveis manifestou associação significante entre estado nutricional, nível sérico de fósforo e Kt/V. Conclui-se então que a maioria dos participantes apresentavam adequado estado nutricional e eficiência dialítica, com correlação significativa entre si.
Avaliação dos efeitos da suplementação com selênio no estresse oxidativo em ovários de ratas
Authors: Gueiber Tiago Daniel , Santos André Amaro Mamédio dos , Lima Luiz Gustavo , Salina Matheus Von Jelita , Pironatto Vitor Hugo Moro , Lepinski Julia Kapp , Secco Guilherme Linha , Benitez Jenifer Gabrielle , Martins Camila Marinelli , Gomes Ricardo Zanetti 
Published: May 2022

O objetivo do presente trabalho foi avaliar o efeito da suplementação de selênio (Se) no estresse oxidativo de ovários de ratas. Para isso, 36 ratas foram divididas em 3 grupos (grupo controle, grupo 1 - 48 μg de Se, e grupo 2 - 96 μg de Se), que passaram por gavagem diária com selênio quelado durante 6 semanas, e em seguida foram submetidas a histerectomia total e subsequente dosagem total de TIOL e TBARS dos ovários utilizando espectrofotometria. Como resultados, houve queda estatisticamente significativa dos níveis de TBARS entre o grupo 1 (3,07±3,19 nM) e o grupo 2 (0,54±0,80 nM) (p=0,01). Em relação ao TIOL, não houve diferença significativa entre o grupo controle (51,05 ± 35,02 μg SH-NP. g tecido-1), o grupo 1 (61,15 ± 33,47 μg SH-NP. g tecido-1) e o grupo 2 (62,9 ± 18,04 μg SH-NP. g tecido-1) (p=0,883). Concluiu-se que a suplementação de selênio reduziu de forma significativa a concentração de TBARS no ovário de ratas e que não houve diferença estatisticamente significativa nos níveis de TIOL dos ovários entre os grupos. Portanto, o selênio exerceu efeito sobre alguns marcadores de estresse oxidativo.
A Logística Reversa como um diferencial competitivo
Authors: Rodrigues Roberta Oliveira 
Published: May 2022

O presente artigo tem por finalidade especificar a importância da Logística Reversa, tendo em vista que o contexto atual do mercado é de bastante concorrência e sobre um aspecto que só agora começa a ter um olhar atencioso por parte das empresas. Em relação a isso as empresas encontraram na logística reversa, uma forma eficaz de adotarem princípios mais sustentáveis, uma vez que a logística reversa pode ser definida como a direção do fluxo de materiais do seu ponto de consumo até o ponto de origem, que precisa ser gerenciado. Nota-se que a Logística Reversa pode ser utilizada em diversos setores da economia, porém ainda encontra muitas dificuldades e necessidades para se adequar nesse ambiente empresarial. Além de apresentar diferenciação em serviço ao cliente, à medida que o fabricante tem políticas mais acessíveis de retorno de produtos, apresentando uma vantagem em relação a concorrência. A pesquisa qualitativa procura mostrar aspectos positivos para implementar um sistema de logística reversa, trouxe dados importantes de modo que a mesma se torne um aspecto de desenvolvimento sustentável por pesquisadores em publicações nacionais e sendo parte de procedimentos de empresas de vários setores, pois atualmente todas desejam utilizar e produzir produtos ecologicamente corretos.
Lessons for a SECURE Future: Evaluating Diversity in Crop Biotechnology Across Regulatory Regimes
Authors: George Dalton R. , Hornstein Eli D. , Clower Carrie A. , Coomber Allison L. , Dillard DeShae , Mugwanya Nassib , Pezzini Daniela T. , Rozowski Casey 
Published: May 2022

Regulation of next-generation crops in the United States under the newly implemented “SECURE” rule promises to diversify innovation in agricultural biotechnology. Specifically, SECURE promises to expand the number of products eligible for regulatory exemption, which proponents theorize will increase the variety of traits, genes, organisms, and developers involved in developing crop biotechnology. However, few data-driven studies have looked back at the history of crop biotechnology to understand how specific regulatory pathways have affected diversity in crop biotechnology and how those patterns might change over time. In this article, we draw upon 30 years of regulatory submission data to 1) understand historical diversification trends across the landscape and history of past crop biotechnology regulatory pathways and 2) forecast how the new SECURE regulations might affect future diversification trends. Our goal is to apply an empirical approach to exploring the relationship between regulation and diversity in crop biotechnology and provide a basis for future data-driven analysis of regulatory outcomes. Based on our analysis, we suggest that diversity in crop biotechnology does not follow a single trajectory dictated by the shifts in regulation, and outcomes of SECURE might be more varied and restrictive despite the revamped exemption categories. In addition, the concept of confidential business information and its relationship to past and future biotechnology regulation is reviewed in light of our analysis.
PCSK9 Contributes to the Cholesterol, Glucose, and Insulin2 Homeostasis in Seminiferous Tubules and Maintenance of Immunotolerance in Testis
Authors: Pelletier R.-Marc , Layeghkhavidaki Hamed , Seidah Nabil G. , Prat Annik , Vitale María L. 
Published: May 2022

The PCSK9 contribution to cholesterol and immunotolerance homeostasis and response to glucose, and insulin in testis and hypophysis were studied usingPcsk9-deficient (−/−) and transgenic [Tg (PCSK9)] mice, and diabetic, obeseob/obanddb/dbmice. The spermatids/spermatozoa acrosome, peritubular vessels, and epididymal adipocytes were PCSK9- and LDL-R-positive. The pro-PCSK9/PCSK9 ratio was high in interstitial tissue-fractions (ITf) and spermatozoa and low in seminiferous tubule-fractions (STf) in normal adult mice. This ratio decreased in ITf inob/obanddb/dbmice but increased in tubules inob/obmice. Deletingpcsk9lowered cholesterol in serum but increased testicular cholesterol. Furthermore, HMGCoA-red, ACAT-2 and LDL-R turnover increased whereas SR-BI decreased in ITf; in tubules, ABCA1 decreased and 160 kDa LDL-R increased inPcsk9−/−mice. Excess testicular cholesterol could result from increased cholesterol synthesis and uptake with reduction in SR-BI-mediated efflux in ITf and from the overload of apoptotic cells, lowered ABCA1-mediated efflux and stimulated LDL-R protein synthesis in tubules inPcsk9−/−mice. Concomitantly with the cholesterol accumulation, tubules showed infiltrates of immune cells, elevated IL-17A and IL-17RA, and changes in the immunotolerance homeostasis. PCSK9 deficiency decreased glucose in tubules and spermatozoa while increasing insulin2 in ITf and tubules not serum. Moreover, IR-α, and IR-β augmented in tubules but decreased in the anterior pituitary; IR-α increased whereas IR-β decreased in ITf. The histology and cholesterol levels were normal in Tg (PCSK9) mouse testis. The excess cholesterol creates a milieu favorable to the action of high IL-17A and IL-17RA, the development of inflammatory conditions and self-tolerance breakdown in testis.
Synthesis and Characterization of Dispersible Geopolymer Nanoaggregates
Authors: Medpelli Dinesh , Seo Dong-Kyun 
Published: May 2022

We present a simple synthetic route to submicron-sized both potassium- and sodium-based geopolymer nanoaggregates whose nanostructure is suitable for applications in polymer composites. The new synthetic method is based on the chemical mechanism of geopolymer formation in which the extent of cross-liking of geopolymer primary particles is dependent of the alkali concentration and the relative amount of water in the precursor mixture. The products exhibited ∼50–60 nm-sized primary particles along with ∼15–20 nm-sized smaller particles. The external surface areas of the products were high, up to 231 m2/g, especially for the sodium-based geopolymer. The primary particles are fused together to form aciniform nanoaggregates with average size of about 400 nm and mesopore volume up to about 0.59 cm3/g. The zeta potential of the nanoaggregates was below ‒ 40 mV in the pH range of 5.7–12, demonstrating that the particles are stable in this pH region and do not undergo aggregation and/or agglomeration. All these characteristics make the new material favorable in application of the material in nanofiller application.
Mitofilin Mitigates Myocardial Damage in Acute Myocardial Infarction by Regulating Pyroptosis of Cardiomyocytes
Authors: Ma Min , Liang Shi-chu , Diao Kai-yue , Wang Qin , He Yong 
Published: May 2022

BackgroundAcute myocardial infarction (AMI) can lead to sudden cardiac death after prolonged ischemia or heart failure (HF) and impaired left ventricular pump function. However, the underlying mechanism remains largely unknown. The purpose of this study was to investigate the role of mitofilin in alleviating AMI.MethodsRecombinant adenoviral vectors for mitofilin overexpression or mitofilin knockdown were constructed, respectively. A mouse AMI model was established and the effect of mitofilin on myocardial pyroptosis was examined by detecting the lactate dehydrogenase (LDH) level and inflammatory factors. Moreover, a cellular model of AMI was established by treating cardiomyocytes with hypoxia/reoxygenation (H/R). An enzyme-linked immunosorbent assay (ELISA) and a western blot analysis were used to detect the effect of mitofilin knockdown on the expression of pyroptosis-related factors. Furthermore, the regulatory role of mitofilin in PI3K/AKT pathway was evaluated by the western blot and PI3K inhibitor.ResultsMitofilin was downregulated in the heart tissue of the AMI mice and H/R induced cardiomyocytes. The overexpression of mitofilin significantly alleviated AMI and reduced pyroptosis-related factors. Meanwhile, in cardiomyocytes, mitofilin knockdown aggravated cellular damages by promoting pyroptosis. Further analysis showed that the anti-pyroptotic effect of mitofilin was dependent on the activation of the PI3K/AKT signaling pathway.ConclusionsOur study suggests that mitofilin regulates pyroptosis through the PI3K/AKT signaling pathway in cardiomyocytes to ameliorate AMI, which may serve as a therapeutic strategy for the management of AMI.
Functional Evaluation of Embedded Modular Single-Branched Stent Graft: Application to Type B Aortic Dissection With Aberrant Right Subclavian Artery
Authors: Zhang Xuehuan , Chen Duanduan , Wu Mingwei , Dong Huiwu , Wan Zhengdong , Jia Heyue , Liang Shichao , Shao Jun , Zheng Jun , Xu Shangdong , Xiong Jiang , Guo Wei 
Published: May 2022

BackgroundEndovascular repair of type B aortic dissection (TBAD) with aberrant right subclavian artery (ARSA) is challenging due to anatomical complexity. The embedded modular single-branched stent graft (EMSBSG) could solve this problem. However, the hemodynamic efficacy of this innovative technique has not been fully assessed. This study aimed to propose morphometric and functional indicators to quantify the outcomes of EMSBSG in treating TBAD with ARSA.Material and MethodsA patient who had TBAD with ARSA underwent EMSBSG implantation was admitted. Computational fluid dynamics (CFD) and three-dimensional structural analyses were conducted based on CTA datasets before the operation (Pre-1) and at 4 and 25 days after EMSBSG implantation (Post-1 and Post-2). Quantitative and qualitative functional analyses were conducted via pressure-, velocity- and wall shear stress (WSS) -based parameters, such as the luminal pressure difference (LPD), total energy loss, and flow distribution ratio. By precisely registering the aortas at the three time points, parameter variations in the EMSBSG region were also computed to investigate the prognostic improvement after EMSBSG implantation.ResultsThe first balance point of LPD distally shifted to the abdominal aorta in Post-1 by a distance of 20.172 cm, and shifted out of the dissected region in Post-2, indicating positive pressure recovery post EMSBSG. The flow distribution ratios of all aortic arch branches increased after EMSBSG implantation. A positive normal deformation index in the EMSBSG region confirmed true lumen expansion; dominant ARN (area ratio of negative value) of pressure and WSS-based parameters indicated an improved prognosis from Post-1 to Post-2.ConclusionsThe short-term results of EMSBSG in treating TBAD with ARSA proved to be promising, especially in EMSBSG region. Comprehensive evaluation could provide new insight into the therapy of TBAD with ARSA. Thus, it might guide the further management of complex aortic arch lesions.
Spatiotemporal Impact on Vegetation by Tunnel Discharging in the Jinping II Hydropower Station: Evidence From the NDVI and GPP Monitoring Dataset of 2001–2019
Authors: Song Ci , Huang Runqiu , Tang Xiaolu 
Published: May 2022

An impact on vegetation by tunnel discharging has been a critical point for underground constructions around the world. The Jinping II hydropower station in China possesses the world’s largest karst diversion tunnel group and discharged massive groundwater during the construction period. This study assessed the effects on vegetation in the karst and non-karst areas at different stages before construction (2001–2003, BC), during construction (2004–2014, DC), and after construction (2015–2019, AC) based on the Normalized Difference Vegetation Index (NDVI) and the gross primary productivity (GPP) dataset of the moderate resolution-imaging spectroradiometer (MODIS). The regional median results of the NDVI and GPP showed that the whole vegetation was little changed by massive tunnel drainage throughout BC, DC, and AC. The NDVI and GPP were locally decreased in the first 3 years, and then recovered to the original level within next several years. Notably, the NDVI and GPP of the karst area (20 and 50% in the total area) were decreased more significantly than those of the non-karst area (8 and 20% in the total area). The factors controlling vegetation change are the development of karst and fractures, which are the conduits of groundwater flow. Therefore, massive groundwater discharge is the primary influence leading to the vegetation deterioration in the Jinping II hydropower station. The research would provide a vital reference for vegetation protection of large-scale underground construction in the world.
Mechanical Characteristics of Heishan Bentonite for Hazardous Waste Contamination Prevention
Authors: Xu Jian-Hua , Li Kai , Sun Ke-Ming , Zhang Shu-Cui 
Published: May 2022

A series of laboratory-based water infiltration tests at room temperature have been conducted to investigate the mechanical characteristics of Heishan bentonite as a potential backfill material. The experiments were performed with an oedometer testing apparatus which facilitates the mechanical loading, the water infiltration, and the deformation measurement. The results show that both swelling pressure-initial dry density and swelling strain-moisture content have an exponential relationship. Moreover, swelling strain dramatically decreases when the applied stress exceeds a reference stress of 100 kpa. Finally, permeability tests were carried on Heishan bentonite specimen and the studied material reaches an impermeable state when the moisture content is larger than 40%. The presented properties certificate that Heishan bentonite can be employed as a backfill material in engineering practice.
Influence of Maternal Age on the Relationship Between Endometrial Thickness and Ongoing Pregnancy Rates in Frozen–Thawed Embryo Transfer Cycles: A Retrospective Analysis of 2,562 Cycles
Authors: Tian Haiqing , Zhang Hejiang , Qiu Hong , Yang Xuejiao , La Xiaolin , Cui Lei 
Published: May 2022

BackgroundIn frozen–thawed embryo transfer (FET) cycles, endometrial thickness (EMT) has been used routinely as the main clinical monitoring index. However, the current findings are conflicting.MethodThis was a single-center retrospective study of 2,054 couples (2,562 cycles) who underwent FET (including cleavage stage embryos and blastocysts) between January 2017 and August 2020 in the reproductive centers of First Affiliated Hospital of Xinjiang Medical University. The primary outcome measure was the ongoing pregnancy rate (OPR); the secondary outcome was the clinical pregnancy rate.ResultsAfter stratified analysis and adjusting for confounders such as maternal age, duration of infertility, number of high-quality embryos transferred, endometrial preparation protocol, number of transfer cycles, and stages of embryo transferred, we found a curvilinear relationship between EMT and the OPR in women &lt; 35 years of age. For women with EMT ≤ 8 mm, the OPR increased by 150% for cleavage stage embryo transfer for every 1 mm increase in the EMT; similarly, it increased by 97% for blastocyst stage FET. However, there was a linear relationship between EMT and OPR in women aged ≥ 35 years. When blastocysts were transferred, for every 1 mm increase in the EMT the OPR increased significantly by 12%. But OPR after frozen-thawed cleavage stage embryos transfer did not increase significantly with increased EMTConclusionsOur study showed that the OPR increased significantly with increased EMT between young women aged &lt; 35 years with EMT ≤ 8 mm and older women who underwent transfer of blastocysts.