bluuebunny/crossref_metadata_2025_split huggingface dataset:
SINTESIS KEMOSENSOR ION CN- BERBASIS TURUNAN PIRAZOLIN DENGAN LOGAM Cu
Authors: Syahputri Yulian , Purwati Diah Indah , Sutanto Sutanto , Taufiq Agus 
Published: June 2022

One of the toxic anions such as cyanide (CN-) has a negative impact on living things. Pyrazoline derivatives can be complexed with transition metals and used as CN- ion fluorosensor, because pyrazoline derivatives have fluorescence properties. This study aims to synthesize of CN- ion chemosensors based on pyrazoline derivative namely para-di-2-(1-phenyl-3-pyridyl-4,5-dihydro-1H-pyrazole-5-yl)benzene with Cu metal. The resulting complex compounds were characterized using Spectrophotometer Infra Red (FTIR), Spectrophotometer UV-Visible, and Spectrofluorometer. Then, a complex compound chemosensor (fluorosensor) study of Cu2+ was carried out with the addition of CN- ions using a spectrofluorometer. The results showed that the synthesis of complex compound Cu2+ was successfully carried out and a brown precipitate was obtained with a yield of 43% with a melting point of 243.3°C. Based on the results of characterization by FTIR (cm-1) generates 3400 (Amine), 2920.88-2852.42 (C-H pyridine), 2360.38 (C=N), 1594.50-1490.39 (C=C aromatic), 1233.67-1021.17 (C-N), 982.66 (Cu-O), 348.00 (Cu-N), and 320-280 (Cu-Cl). The results of the spectroscopy UV-Visible analysis Cu2+ complex compounds at a concentration of 5x10-5 M obtained two absorption peaks, 242 nm and 306 nm. The result of the spectrofluorometer analysis of Cu2+ complex compound were 1516 a.u at a wavelength of 502 nm. The results of the chemosensor (fluorosensor) studies of the Cu2+ complex compound with the addition of CN- ions can be used as a turn on-off type fluorosensor.
Chicken Bone Based Adsorbent for Adsorption of Pb(II), Cd(II), and Hg(II) Metals Ion Liquid Waste
Authors: Hasanah Uswatun , Iryani Ani , Taufiq Agus , Darma Putra Dimas Apryandi 
Published: June 2022

High productivity of chicken meat for supplying society also make some impact in high productivity of chicken bone and because it’s unraveling properties makes this become waste. Pharmaceutical’s Waste comes from production process, adstertion of production tools, laboratory activities and rejected product. Laboratory’s routine analysis also producing residual waste analysis, one of the source is come from heavy metals analysis of Pb, Cd, dan Hg. General process for waste treatment producing high quantity of sludge, mean while using third party service have impact in high costing of transportation and treatment process. An alternatif way for this case is using sorption treatment. Initial research starts from preparation of chicken bone-based adsorbent and its characterization using SEM and FTIR, followed by quality analysis of fresh waste (which is waste A and waste B) observed at pH, COD, TDS, TSS also Pb, Cd, dan Hg metals. Adsorption process was observed from adsorbent’s graying temperature, adsorbent’s particle size, contact time, pH of waste, and adsorbent’s weight. Best result from adsorption process were applicated at fresh waste and simulation waste of Pb, Cd, and Hg metals also re-testing quality analysis of fresh waste and simulation waste for before-after result comparing purpose. The purpose of this research is for characterizing chicken bone-based adsorbent, observing adsorption process of Characterization of chicken bone ash based adsorbent has been carried out in adsorbing Pb, Cd, and Hg metals in pharmaceutical laboratory waste. Functional group analysis with Fourier Transform Infrared Spectrophotometer (FTIR) showed that the chicken bone ash adsorbent contained the mineral compound apatite carbonate. Surface morphology with a Scanning Electron Microscope (SEM) shows that the adsorbent surface is porous and appears to be adsorbing metals. From the adsorption observations, it was found that the best adsorption conditions were at an ashing temperature of 800 oC, particle size of 80 mesh, contact time of 30 minutes, waste conditions at pH 6 and an adsorbent weight of 600 mg. Application chicken bone-based adsorbent against pharmaceutical waste shows its existence improve the quality of waste but still do not meet the quality standard requirements for Hg metal.
MODEL WAKTU TUNGGU KENDARAAN DI PERSIMPANGAN LALU LINTAS MENGGUNAKAN DISTRIBUSI COMPOUND POISSON ARRIVALS
Authors: . Nani , Wijayanti Hagni , Virgantari Fitria 
Published: June 2022

This study aims to apply mathematical models of traffic conditions at crossroads and determine the length of waiting times for vehicles with compound poissson distribution arrival patterns as well as determine the length of the green light phase and red light phase so that reduce traffic congestion at intersections. The data used is data from the Bogor Highway Transport Traffic Agency (DLLAJR) in 2017. The initial stage of analysis is to divide the waiting time of the vehicle into 2 phases, namely the red light phase and the green light phase. After that apply the Compound Poissson distribution model for the red light phase and the green light phase, then determine the vehicle's waiting time. The next step is the application and simulation of one-cycle vehicle waiting time on Simpang Yasmin road. Based on the results of the analysis, it can be concluded that the waiting time for vehicles in Simpang Yasmin is 80 seconds for each cycle. Simulation produced on the road section in Simpang Yasmin namely Jl. K. H. Sholeh Iskandar (west) for 28 seconds green light time, Jl. K. H Sholeh Iskandar (east) for 16 seconds green light time, and Jl. K. H. Abdullah bin Nuh for 27 seconds green light time.Keywords: green light time, one-cycle vehicle waiting time, Poisson compound distribution, yasmin intersection.
OPTIMASI BIAYA DISTRIBUSI AIR MINUM DALAM KEMASAN MENGGUNAKAN ALGORITMA ANT COLONY SYSTEM (Studi Kasus : PT. Tirta Investama Cibinong)
Authors: Samsudin Mulyana , Wijayanti Hagni , Setyaningsih Sri 
Published: June 2022

Aqua is a brand of bottled drinking water produced by PT Aqua Golden Mississippi Tbk. The products produced by PT Aqua Golden Mississippi Tbk are distributed by PT Tirta Investama Cibinong. PT Tirta Investama Cibinong distributed the 15 stores spread across several areas, the distribution of the 15 existing stores could be done by various routes. In its distribution activities, the company does not yet have an optimal route, so the most optimal route is needed so that the costs incurred are minimum. Ant Colony System Algorithm is a method that aims to find the best path in a distribution problem, based on the behavior of ants. The purpose of this study is to obtain the minimum cost in delivering bottled drinking water to several areas using the Ant Colony System Algorithm so as to meet the demand for mineral water in the area. The data used is shipping costs between stores in 2018. It is certain that the Ant Colony System Algorithm obtains the optimal path from Cibinong Depot, Indomaret Cibedug, Alfamidi Gadog, PT Sumber Alfaria Trijaya TBK, Pujasari, PT Sumber Alfaria Trijaya, Lion Superindo Town Square, TipTop Depok, Indomaret Happiness Raya, Lion Superindo Depok, Lion Superindo Cibubur, DC Starmart, Pajajaran gas station, Circle K Sudirman Bogor, Wholesale Lotte Bogor and finally back to Depo Cibinong with shipping costs of Rp. 244,420. Keywords: Ants, Ant Colony System, Traveling Salesman Problem
METODE TAGUCHI DALAM ANALISIS PENGENDALIAN KUALITAS PRODUK FURNITURE
Authors: Octariani Irna , Virgantari Fitria , Wijayanti Hagni 
Published: June 2022

This research was conducted to analyze the quality control of furniture products in PT. Hadinata Brothers, to find the cause of product quality that did not match specifications, the causative factors of significant defective products, to find an optimal combination of settings and minimized defective products in order to maintain good quality using the Taguchi Method. The data used in this study is data on defective products in PT. Hadinata Brothers. Furthermore, the data is processed using several methods including pareto diagram, causal diagram (fishbone), Taguchi Method, Analysis of Variance (ANOVA). From the results of the analysis, the control of defective products 36.4% was outside the lower limit of control and 85.7% was outside the upper limit of control with the limits of control CL = 0.0572, UCL = 0.0818, LCL = 0. The highest percentage of defects is handling, which is 59.5%, the second order is assembly, which is 23.3%, and the third is finishing, which is 17.2%. Factors that significantly affect the quality of products based on the results of ANOVA calculations are factor A (handling raw materials) and factor B (type of wood) because Fcalc F-table which are 6.2178 2, 37 and 2.3895 2.37. Keywords: quality control, Taguchi Method, defective products, causative factors defect, pareto diagram, fishbone, ANOVA
METODE DOUBLE EXPONENTIAL SMOOTHING DALAM PERAMALAN JUMLAH PEMOHON PASPOR (Studi Kasus : Kantor Imigrasi Kelas II Non-TPI Depok)
Authors: Seno Natalia Medya Lifa Ir , Kamila Isti 
Published: June 2022

The Immigration Office of Class II Non-TPI Depok City is an institution that provides services engaged in the field of immigration, one of which is providing passport processing services. This increase in the number of passport applicants will have an impact on the availability of facilities, infrastructure, and passport management services which often reach 2000 – 3000 passports per month in 2018. From the problems above, the author offers a solution, namely by predicting the number of passport applicants. There are several methods used to solve this problem, including the double exponential smoothing method as the method that will be tested in this study This method uses parameter values obtained from trial and error calculations to produce accurate values because the data is fluctuating so it requires smoothing parameters. If the data used a lot in the calculation of forecasting then MAPE (Mean Absolute Percentage Error) forecasting will be smaller and vice versa . The results of the forecasting of passport creation applications produced by the Double Exponential Smoothing Method with a parameter of α = 0.4 (selection of the best alpha between 0 to 1) obtained a MAPE value of 14.28%. MAPE criteria that are worth 14.28% belong to the category of GOOD in forecasting the application for passport creation in the period to be obtained.
FORMULASI, KARAKTERISASI DAN EVALUASI SELF-NANO EMULSIFYING DRUG DELIVERY SYSTEM (SNEDDS) EKSTRAK ETANOL KULIT BUAH NANAS SEBAGAI ANTIBAKTERI STREPTOCOCCUS MUTANS
Authors: Indratmoko Septiana , . Suratmi , Issusilaningtyas Elisa 
Published: June 2022

Kulit buah nanas mengandung bromelain, flavonoid, tannin, dan saponin yang dapat dimanfaatkan sebagai antibakteri. Perkembangan teknologi formulasi diperlukan untuk meningkatkan aktivitas antibakteri. Ekstrak kulit buah nanas memiliki sifat kurang larut dalam air sehingga efek farmakologinya terbatas. Formulasi SNEDDS diharapkan mampu meningkatkan aktivitas antibakteri agar dapat bekerja secara maksimal. Penelitian ini bertujuan untuk mengetahui formula optimum SNEDDS ekstrak kulit buah nanas, karakterisasi nanoemulsi dan aktivitas antibakteri. Pengujian terhadap 14 formula dari Simplex Lattice Design menghasilkan formula optimal SNEDDS ekstrak kulit buah nanas dengan komposisi 1 (VCO) : 5 (surfaktan) : 1 (kosurfaktan) dengan desirability 0,995 dan uji drug loading 100 mg/5 mL. Uji karakterisasi berupa pengukuran droplet size dengan rata-rata 15,06 nm, potensial zeta -14,3 mV, transmitan 98,6%, emulsification time 24:93 detik, uji stabilitas fisik stabil. Uji antibakteri dilakukan dengan metode sumuran. Daya antibakteri SNEDDS ekstrak kulit buah nanas terhadap bakteri Streptococcus mutans tergolong kuat dengan ukuran zona bening 11,19 mm.
UJI AKTIVITAS EKSTRAK ETANOL 96% DAN FRAKSI DAUN KIRINYUH (Chromolaena odorata L.) TERHADAP PROPIONIBACTERIUM ACNES
Authors: Komala Oom , . Yulianita , Rahmawati Rita 
Published: June 2022

Chromolaena odorata L. leaves can be used as an antibacterial because of contain flavonoid compounds. The secondary metabolite content of Chromolaena odorata L leaves include flavonoids, tannins, saponins, and steroids which have antibacterial activity. The aim of this study was determine the antibacterial activity of ethanolic 96% and fraction of Chromolaena odorata L leaves and determine the concentration of Chromolaena odorata L fraction and ethanol 96% extract which was most effective as an antibacterial against Propionibacterium acnes. The method was used to determine the MIC was a solid dilusion method, while the determination of inhibitory zone by the paper disk diffusion method at concentrations of 10%, 15% and 20% in each sample. The MIC showed hexane fraction is 15%, ethylacetate fraction is 15% and water fraction is 10%. The best antibacterial activity in the ethylacetate fraction and ethanol 96% extract at a concentration of 20% with the width of the zone of inhibition values of 4.375 mm and 4 mm.
STUDI PERBANDINGAN EFEK DIURETIK DAN ANTIINFLAMASI GABUNGAN EKSTRAK SIDAGURI, TEMPUYUNG DAN SELEDRI PADA TIKUS
Authors: Rahminiwati Min , Jannah Raudhatul , Mohamad Kusdiantoro 
Published: June 2022

Sidaguri (Sida rhombifiola L.), tempuyung (Sonchus arvensis L.), dan seledri (Apium graveolens L.) dilaporkan mengandung flavonoid yang berperan penting dalam mekanisme terjadinya efek diuretik dan antinflamasi beragam herbal. Namun potensi flavonoid dalam menimbulkan kedua efek tersebut berbeda pada setiap tanaman baik tunggal maupun ramuan. Penelitian ini ditujukan untuk mempelajari kekuatan efek diuretik dan antiinflamasi dari gabungan ketiga tanaman tersebut pada tikus. Lima ekor tikus dari masing masing kelompok uji diuretik dan 4 ekor tikus dari kelompok antiinflamasi diberi aquadest sebagai grup kontrol, ekstrak tempuyung 28 mg/200 g BB, dan kombinasi ketiga tanaman dosis 28 mg/200 g BB, 56 mg/200 g BB, dan 280 mg/200 g BB secara oral selama 8 hari berturut turut. Total volume urin kelompok tikus diuretik diukur pada hari ke 8 sampai dengan hari ke 10 sedangkan volume udem kaki tikus yang diinduksi karagenan kelompok tikus antiinflamasi diukur 30 menit sebelum dan sesudah induksi dan setiap jam selama 6 jam. Data yang diperoleh menunjukkan bahwa sediaan dosis 56 mg/kg BB mempunyai total volume urin dan percent diuretic index lebih besar dari kontrol dan pada dosis 28 mg/kg BB mempunyai nilai AUC terendah serta % DAI tertinggi. Dengan demikian sediaan. mempunyai efek antiinflamasi lebih kuat dibandingkan dengan efek diuretik.
PENGARUH GASTROPROTEKTOR KOMBINASI TEPUNG GARUT (Marantha arundinaceae) DAN KUNYIT (Curcuma domestica Val.) PADA TIKUS MODEL TUKAK LAMBUNG
Authors: Bachri Moch. Saiful , Sofia Vivi , Khairunnisa Cipta 
Published: June 2022

Tukak lambung atau lebih populer dengan penyakit maag, banyak terdapat pada masyarakat baik di Indonesia maupun di dunia. Kecenderungan masyarakat Indonesia memilih pengobatan tradisional (jamu) sejak dahulu untuk swamedikasi karena biayanya terjangkau dan efektif. Salah satunya untuk mengobati tukak lambung dinilai lebih aman dibanding dengan obat sintesis. Tukak lambung terjadi karena adanya kelebihan asam dan pepsin yang dapat disebabkan oleh stress-related mucosal damage. Tepung garut dan kunyit baik secara empiris dan ilmiah masing-masing dikatakan mampu mengurangi tukak lambung. Penelitian ini bertujuan untuk mengidentifikasi pengaruh gastroprotektor kombinasi tepung garut dan kunyit terhadap nilai indeks tukak lambung dan gambaran histopatologinya pada tikus putih galur Wistar model tukak lambung. Tikus dibagi ke dalam kelompok normal, kontrol tukak diberi etanol 96% dosis 1 ml/ 200 g/BB,kontrol positif sukralfat dosis 200 mg/kgBB, perlakuan I; II; III diberi tepung garut 200 mg/kgBB, kunyit 250 mg/kgBB,kombinasi tepung garut dan kunyit 200 mg/kgBB. Perlakuan diberikan secara oral. Pengamatan dilakukan selama tujuh hari dan diikuti dengan puasa selama 24 jam pada hari ke delapan selain kelompok normal, semua kelompok diinduksi etanol 96% dengan dosis 1 ml/200gBB. Setelah satu jam, tikus dikorbankan dan lambungnya diambil. Pengujian antiulcer dihitung dengan indeks tukak lambung dan secara deskriptif dianalisis histopatologinya. Hasil penelitian menunjukkanbahwa pemberian dosis tunggal dan kombinasi menghasilkan indeks tukak berturut-turut 1,80; 1,47; 1,33 secara nyata lebih rendah dibandingkan kontrol negatif (4,42) dan rasio proteksi (%) pemberian kombinasi tepung garut dan kunyit 200 mg/kgBB lebih tinggi dibandingkan kontrol positif. Gambaran histopatologi menunjukkan adanya perbaikan jaringan pada pemberian kunyit 250 mg/kgBB dan kombinasi tepung garut dan kunyit 200 mg/kgBB.
ANTIOXIDANT AND ANTI-INFLAMMATORY EFFECT OF Morinda citrifolia: A META-ANALYSIS AND SYSTEMATIC REVIEW
Authors: Vashti Ervina , Fernando Oen Bernard Christoper , Yonatan Eric Ricardo , Sabatina Venna Bella , Sean Sherlyn , Rukmini Elisabeth 
Published: June 2022

Morinda citrifolia (noni) is a tropical plant from the Rubiaceae family, which contains various active components that have several functions in medical fields that can act as an antioxidant and anti-inflammatory. To assess both effects, we conducted a systematic review and meta-analysis, with the PRISMA statement guidelines, to discuss the efficacy of Morinda citrifolia as an antioxidant and anti-inflammatory. The literature search was performed by searching through 12 databases: Sage Journals, ScienceDirect, Garuda, ProQuest, PubMed, Google Scholar, Web of Science, Taylor and Francis, Wiley Online Library, Cochrane Library, EBSCO, and SINTA from 2000 to 2020. From 4.605 identified record journals, we found six journals which were included in our study analysis. Our analysis showed that Morinda citrifolia has a moderate positive effect as antioxidant and anti-inflammatory agents, with an overall effect size of correlation 0.46 (CI 95% was 0.37-0.54). This study proves the potential of Morinda citrifolia as an alternative herbal medicine. Future research and studies are expected on Morinda citrifolia to investigate its further potential.
EFEKTIVITAS ANTIFUNGI MINYAK ATSIRI KENANGA (Cananga odorata) TERHADAP Aspergillus flavus
Authors: . Triastinurmiatiningsih , Haryani Tri Saptari , Wahid Ghina Athyah 
Published: June 2022

Aspergillus flavus merupakan kapang penghasil utama aflatoksin yang banyak mengkontaminasi komoditi kacang-kacangan, biji-bijian, dan serealia. Bahan alami yang dapat digunakan untuk mengatasi permasalahan tersebut dengan penggunaan minyak atsiri kenanga (Cananga odorata). Tujuan penelitian ini adalah untuk mengetahui senyawa fitokimia dan menguji aktivitas antifungi dari minyak atsiri kenanga (C. odorata) terhadap A. flavus. Penentuan Konsentrasi Hambat Minimum (KHM) menggunakan metode dilusi padat dengan konsentrasi 10%, 20%, 30%, dan 40%, dan penentuan Diameter Daerah Hambat (DDH) dengan metode difusi agar sumuran menggunakan lima macam perlakuan yaitu tiga konsentrasi 40%, 50%, dan 60%, kontrol positif (Ketokonazol 50 mg/L), dan kontrol negatif (Tween 80) sebanyak 50 µl. Data hasil tes DDH kemudian dianalisis menggunakan ANOVA dengan tingkat kepercayaan 95% dan α = 0,05 dilanjutkan uji Duncan. Senyawa kimia yang terkandung dalam minyak atsiri kenanga adalah flavonoid, alkaloid, saponin dan triterpenoid. Hasil konsentrasi hambat minimum didapat pada konsentrasi 40%, sedangkan pada uji DDH, konsentrasi 60% merupakan konsentrasi yang paling optimum menghambat pertumbuhan kapang A. flavus dengan rerata daerah hambat 12,34 mm
TOKSISITAS AKUT SEDIAAN CAIR BERBASIS BAWANG PUTIH DENGAN METODE ZEBRAFISH EMBRYO TOXICITY (ZFET)
Authors: Wiendarlina Ike Yulia , Herlina Nina , Mareta Elsa 
Published: June 2022

Sediaan cair berbasis bawang putih (SCBBP) terbuat dari campuran beberapa bahan diantaranya yaitu bawang putih tunggal, jahe merah, sari buah lemon, cuka apel, dan madu. Sediaan ini memiliki berbagai khasiat farmakologis, namun belum ada penelitian yang menguji batas keamanan sediaan tersebut. Tujuan dari penelitian ini adalah untuk menentukan toksisitas akut dari SCBBP menggunakan metode ZFET (Zebrafish Embryo Toxicity) mengacu pada tatalaksanaOrganization for Economic Cooperation and Development (OECD). Embrio diberi paparan SCBBP dengan berbagai konsentrasi (50, 100, 200, 400, 600, 800, 1200, 1600 dan 2000 ppm) mulai dari 8 jam pasca-pembuahan (jpf) hingga 96 jpf. Data abnormalitas dan kematian yang diperoleh dianalisis secara statistik untuk memperoleh nilai LC50, EC50 dan Indeks teratogen (TI). Hasil pengujian menunjukkan bahwa kelangsungan hidup embrio semakin menurun dengan semakin meningkatnya konsentrasi dan lama paparan SCBBP yang diberikan. Nilai rata-rata LC50 pada 24; 48; 72; dan 96 jpf adalah sebesar 1548 ppm; 1382 ppm; 1247 ppm; dan 1209 ppm, sedangkan nilai EC50 adalah sebesar 418,041 ppm, 306,445 ppm, 417,529 ppm dan 375,622 ppm dan nilai indeks teratogenic (TI) 1. Berdasarkan hasil penelitian, disimpulkan bahwa SCBBP termasuk ke dalam kategori relatif tidak berbahaya dan tidak bersifat teratogen terhadap model embrio ikan zebra.
STUDI PENAMBATAN MOLEKUL DAN PREDIKSI ADMET SENYAWA METABOLIT SEKUNDER TANAMAN KELOR (Moringa oleifera L.) SEBAGAI INHIBITOR BACE1 PADA PENYAKIT ALZHEIMER
Authors: Apriali Kirka Dwi , Triana Efi , Farhani Meigita Indah , Khoirunnisa Arina , Nur’aini Yuniar Alfain 
Published: June 2022

Alzheimer merupakan penyakit neurodegeneratif yang ditandai dengan adanya deposisi amiloid, kusut neurofibrillary, disfungsi sinaptik, dan kematian sel saraf. Patofisiologi utama dari neurodegeneratif yaitu adanya produksi yang berlebihan atau akumulasi β-amiloid (Aβ), yang memiliki beberapa efek merusak pada aktivitas sinaptik. Aβ dihasilkan dari protein prekursor amiloid (APP) melalui pembelahan proteolitik oleh enzim pembelahan APP situs-1 (BACE1). Terapi farmakologi untuk alzheimer pada saat ini hanya berfungsi untuk mengurangi gejalanya saja dan tidak berpengaruh pada perkembangan penyakit alzheimer. Moringa oleifera L. atau kelor memiliki efek nootropik dan dapat meningkatkan memori serta melindungi dari neurodegenerasi. Hasil penelitian menunjukkan bahwa niazirin yang terdapat pada tanaman kelor memiliki interaksi terbaik dengan reseptor BACE1 yang ditunjukkan dengan nilai energi ikatan (∆G) sebesar -4,13 kkal/mol yang memiliki ikatan hidrogen pada gugus alkoksi dengan asam amino ARG68 dan ASN175 serta interaksi hidrofobik pada gugus benzena dengan LEU228. Niazirin memiliki profil farmakokinetik yang baik dan dapat menembus sawar darah otak yang sesuai dengan desain obat alzheimer.
THE ACTIVITY OF GEL EXTRACT MAHKOTA DEWA FRUITS [(Phaleria macrocarpa (Scheff.) Boerl] THROUGH TYROSINASE ENZYME INHIBITOR
Authors: Eff Aprilita Rina Yanti , Noviyanti Erika , Pertiwi Ratih Dyah 
Published: June 2022

Mahkota dewa fruit [(Phaleria macrocarpa (Scheff.) Boerl] contains benzophenone derivatives which have sun protection activity and flavonoid compounds which can act as tyrosinase inhibitors. This study aimed to determine the tyrosinase inhibitor activity of 70% ethanol extract of Mahkota Dewa fruit and gel extract of Mahkota Dewa fruits with variations in concentrations of 1.25% (F1), 2.5% (F2), and 5% (F3). Assay of tyrosinase inhibitor activity against ethanol extract of Mahkota Dewa fruit and ethanol extract was done with various concentrations (31.25, 62.5, 125, 250, and 500 µg/ml), using a positive control of Kojic acid and L-DOPA as a substrate. Absorbance measurement was carried out using UV-vis microplate reader with a wavelength of 480 nm. The results showed that the ethanolic extract Mahkota Dewa had an IC50 value of 6668.06 µg/ml while kojic acid as a positive control possessed an IC50 value of 4.22 µg/ml. Gel preparation of the ethanol extract has inhibitor activity of the enzyme tyrosinase represent moderate values of the IC50each, i.e., F1 (1.25%) amounted to 285.03 µg/ml, F2 (2.5%) amounted to 373.25µg/ml, and F3 (5%) of 397.40 µg/ml. The tyrosinase inhibitor activity of the 70% ethanol extract of Mahkota Dewa fruit was lower with a relative potency of 5.167 x 10-3 times compared to that of kojic acid.