bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ipilimumab and nivolumab in advanced hepatocellular carcinoma after failure of prior immune checkpoint inhibitor-based combination therapies: a multicenter retrospective study
Authors: Roessler Daniel , Öcal Osman , Philipp Alexander B. , Markwardt Daniel , Munker Stefan , Mayerle Julia , Jochheim Leonie S. , Hammer Katharina , Lange Christian M. , Geier Andreas , Seidensticker Max , Reiter Florian P. , De Toni Enrico N. , Ben Khaled Najib 
Published: July 2022

AbstractIntroductionImmune checkpoint inhibitor (ICI)-based regimens are transforming the landscape of hepatocellular carcinoma (HCC) treatment. We describe the effect of combined ipilimumab and nivolumab in patients with advanced HCC after the failure of prior ICI-based combination treatments.MethodsThe clinical course of patients with advanced HCC who received combined ipilimumab and nivolumab after prior ICI-based combination therapies was assessed. Progression-free survival (PFS), overall response rate (ORR) and disease control rate (DCR) per RECIST v1.1 and mRECIST, overall survival (OS), and safety were analyzed.ResultsOf 109 patients treated with atezolizumab and bevacizumab or other ICI-based combination treatments, ten patients received subsequent therapy with ipilimumab and nivolumab. The majority of patients had Barcelona Clinic Liver Cancer (BCLC) Stage C (80%) HCC and a preserved liver function as defined by Child–Pugh A (80%). At a median follow-up of 15.3 months, ORR for ipilimumab and nivolumab was 30% with a DCR of 40%. Median PFS was 2.9 months and the median OS was 7.4 months.ConclusionThis retrospective study demonstrates that combined ipilimumab and nivolumab can be effective and tolerable after prior ICI-based combination therapies and provides a rationale for the prospective clinical evaluation of this treatment sequencing.
Molekularpathologische Diagnostik des Harnblasenkarzinoms – prädiktive und prognostische Marker
Authors: Rüschoff Jan H. , Moch Holger 
Published: July 2022

ZusammenfassungFür Patienten mit einem metastasierten Urothelkarzinom der Harnblase bildete über Jahrzehnte hinweg eine platinhaltige Chemotherapie eine der wenigen verfügbaren Therapieoptionen, die allerdings mit einer schlechten Prognose verbunden war. Erfreulicherweise wurden in den letzten Jahren nicht nur bei den therapeutischen Möglichkeiten deutliche Fortschritte erzielt, sondern auch das Wissen über die molekularen Hintergründe des Harnblasenkarzinoms deutlich erweitert. Um eine personalisierte Anwendung der neuen Therapieansätze zu ermöglichen, werden prädiktive Biomarker benötigt, die meist auf dem Nachweis molekularer Tumorveränderungen basieren. Ziel dieser Arbeit ist ein aktueller Überblick über die molekularen Veränderungen, die daraus entwickelten molekularen Subtypen und die gewebebasierten Biomarkern des Harnblasenkarzinoms. Dazu wurden die aktuelle Literatur und klinische Studiendaten ausgewertet. Für bestimmte molekulare Subtypen des Harnblasenkarzinoms konnte eine prädiktive und prognostische Bedeutung gezeigt werden, jedoch bedarf es für deren Einsatz in der pathologisch-klinischen Routine weiterer (prospektiver) Untersuchungen sowie einer genauen Definition der am besten geeigneten Nachweisverfahren. Eine wichtige neue Therapieoption für das fortgeschrittene Urothelkarzinom ist die Immuntherapie, die allerdings nur bei ca. 25 % der Patienten wirksam ist. Als Biomarker zur Vorhersage eines Therapieansprechens eignen sich neben der immunhistochemisch bestimmten PD-L1(„programmed death ligand 1“)-Expression, auch der MSI(Mikrosatelliteninstabilität)-Status und die Tumormutationslast (TMB). Ferner stellen Veränderungen in den DNA-Reparatur-Genen mögliche Prädiktoren für ein Ansprechen auf Chemotherapie dar.
Endodontic working length measurements of premolars and molars in high-resolution dental MRI: a clinical pilot study for assessment of reliability and accuracy
Authors: Zidan Mousa , Schwindling Franz S. , Juerchott Alexander , Mente Johannes , Gehrig Holger , Nittka Mathias , Hosseini Zahra , Jende Johann M. E. , Heiland Sabine , Bendszus Martin , Hilgenfeld Tim 
Published: July 2022

Abstract
Objectives
To prospectively assess the reliability and accuracy of high-resolution, dental MRI (dMRI) for endodontic working length (WL) measurements of premolars and molars under clinical conditions.

Materials and methods
Three-Tesla dMRI was performed in 9 subjects who also had undergone cone-beam computed tomography (CBCT) (mean age: 47 ± 13.5 years). A total of 34 root canals from 12 molars (4/8, upper/lower jaw; 22 root canals) and 11 premolars (2/9 upper/lower jaw; 12 root canals) were included. CBCT and dMRI datasets were reconstructed to visualize the root canal in one single slice. Subsequently, two radiologists measured the root canal lengths in both modalities twice in blinded fashion. Reliability and accuracy for both modalities were assessed using intraclass correlation coefficients (ICCs) and Bland–Altman analysis, respectively.

Results
Reliability (intra-rater I/II; inter-rater) of dental MRI measurements was excellent and comparable to CBCT for premolars (0.993/0.900; 0.958 vs. 0.993/0.956; 0.951) and for molars (0.978/0.995; 0.986 vs. 0.992/0.996; 0.989). Bland–Altman analysis revealed a mean underestimation/bias (95% confidence interval) of dMRI measurements of 0.8 (− 1.44/3.05) mm for premolars and 0.4 (− 1.55/2.39) mm for molars. In up to 59% of the cases, the accuracy of dMRI for WL measurements was within the underestimation margin of 0 to 2 mm short of the apical foramen AF.

Conclusions
In vivo demonstration and measurement of WL are feasible using dMRI. The reliability of measurements is high and equivalent to CBCT. Nonetheless, due to lower spatial resolution and longer acquisition time, the accuracy of dMRI is inferior to CBCT, impeding its current use for clinical treatment planning.

Clinical relevance
dMRI is a promising radiation-free imaging technique. Its reliability for endodontic working length measurements is high, but its accuracy is not satisfactory enough yet.
Exploring the future building: representational effects on projecting oneself into the future office space
Authors: Weerasinghe Maheshya , Čopič Pucihar Klen , Ducasse Julie , Quigley Aaron , Toniolo Alice , Miguel Angela , Caluya Nicko , Kljun Matjaž 
Published: July 2022

AbstractWhile virtual reality (VR) has been explored in the field of architecture, its implications on people who experience their future office space in such a way has not been extensively studied. In this explorative study, we are interested in how VR and other representation methods support users in projecting themselves into their future office space and how this might influence their willingness to relocate. In order to compare VR with other representations, we used (i) standard paper based floor plans and renders of the future building (as used by architects to present their creations to stakeholders), (ii) a highly-detailed virtual environment of the same building experienced on a computer monitor (desktop condition), and (iii) the same environment experienced on a head mounted display (VR condition). Participants were randomly assigned to conditions and were instructed to freely explore their representation method for up to 15 min without any restrictions or tasks given. The results show, that compared to other representation methods, VR significantly differed for the sense of presence, user experience and engagement, and that these measures are correlated for this condition only. In virtual environments, users were observed looking at the views through the windows, spent time on terraces between trees, explored the surroundings, and even “took a walk” to work. Nevertheless, the results show that representation method influences the exploration of the future building as users in VR spent significantly more time exploring the environment, and provided more positive comments about the building compared to users in either desktop or paper conditions. We show that VR representation used in our explorative study increased users’ capability to imagine future scenarios involving their future office spaces, better supported them in projecting themselves into these spaces, and positively affected their attitude towards relocating.
Proton TOCSY NMR relaxation rates quantitate protein side chain mobility in the Pin1 WW domain
Authors: Danmaliki Gaddafi I. , Hwang Peter M. 
Published: July 2022

AbstractProtein side chain dynamics play a vital role in many biological processes, but differentiating mobile from rigid side chains remains a technical challenge in structural biology. Solution NMR spectroscopy is ideally suited for this but suffers from limited signal-to-noise, signal overlap, and a need for fractional 13C or 2H labeling. Here we introduce a simple strategy measuring initial 1H relaxation rates during a 1H TOCSY sequence like DIPSI-2, which can be appended to the beginning of any multi-dimensional NMR sequence that begins on 1H. The TOCSY RF field compels all 1H atoms to behave similarly under the influence of strong coupling and rotating frame cross-relaxation, so that differences in relaxation rates are due primarily to side chain mobility. We apply the scheme to a thermostable mutant Pin1 WW domain and demonstrate that the observed 1H relaxation rates correlate well with two independent NMR measures of side-chain dynamics, cross-correlated 13C relaxation rates in 13CβH2 methylene groups and maximum observable 3J couplings sensitive to the χ1 side chain dihedral angle (3JHα,Hβ, 3JN,Hβ, and 3JCO,Hβ). The most restricted side chains belong to Trp26 and Asn40, which are closely packed to constitute the folding center of the WW domain. None of the other conserved aromatic residues is as immobile as the first tryptophan side chain of the WW domain. The proposed 1H relaxation methodology should make it relatively easy to measure side chain dynamics on uniformly 15N- or 13C-labeled proteins, so long as chemical shift assignments are obtainable.
Wasserstein-based fairness interpretability framework for machine learning models
Authors: Miroshnikov Alexey , Kotsiopoulos Konstandinos , Franks Ryan , Ravi Kannan Arjun 
Published: July 2022

AbstractThe objective of this article is to introduce a fairness interpretability framework for measuring and explaining the bias in classification and regression models at the level of a distribution. In our work, we measure the model bias across sub-population distributions in the model output using the Wasserstein metric. To properly quantify the contributions of predictors, we take into account favorability of both the model and predictors with respect to the non-protected class. The quantification is accomplished by the use of transport theory, which gives rise to the decomposition of the model bias and bias explanations to positive and negative contributions. To gain more insight into the role of favorability and allow for additivity of bias explanations, we adapt techniques from cooperative game theory.
Re-fluidising the aged gel for high-density alumina green body
Authors: Wu Xiaolang , Zhao Jin , Shimai Shunzo , Mao Xiaojian , Zhang Jian , Wang Shiwei 
Published: July 2022

AbstractA green body with a density as high as possible is critical to diminish the crisis of deformation or cracking when large-size parts are sintered. Here, a new method, i.e., re-fluidising the aged ceramic gel is developed to prepare the high-density green body. Alumina slurry with 56 vol% solid loading and copolymers of isobutylene and maleic anhydride were aged without vaporisation and re-fluidised by non-intrusive shearing after removing the exuded water. The re-fluidised slurry was re-casted. The resultant wet gel was dried and deboned at a low temperature. The relative density of the obtained green body was 64.6%, 1.5% higher than that without aging and re-fluidising. The linear sintering shrinkage of the body decreased by 0.7%. The enhanced green density is explained from the viewpoint of the solid loading and the structure of the slurry.
JUST VENMO ME: Does form of payment affect risk taking and intertemporal choice?
Authors: Hoel Jessica B. , Jain Prachi , Galaty Bridget 
Published: July 2022

AbstractWe use an experiment to examine whether form of payment (cash or mobile money) affects estimates of intertemporal choice and risk taking. We find that form of payment does not affect temporal discounting and risk taking. Given that participants prefer payment via mobile money, the results suggest that there are minimal concerns with using mobile money to pay participants in experimental studies.
Effect of sap-feeding insects, plant characteristics, and weather parameters on sooty moulds in the temperate zone
Authors: Flessa Fabienne , Babel Wolfgang , Kehl Alexandra , Rambold Gerhard , Kohl Matthias 
Published: July 2022

AbstractIn this study, relevant variables were determined to predict the probability of sooty mould biofilm (SMB) occurrence on willow leaves in a multivariate model. Despite a large temporal gap between the main sap-feeding insect (SFI) season in spring (May to June) and the main season of SMBs in late summer and fall (August to September), trees infested with SFIs on four or more observation dates had significantly more SMBs (3.7-fold) toward the end of the growing season. In addition, a horizontal leaf position and recessed leaf veins, traits that may increase the wettability of the leaves, positively influenced SMB occurrence (27.8-fold). Among the weather parameters, those that lead to higher moisture on leaf surfaces, namely high morning and evening relative humidity, higher precipitation sums, and lower vapour pressure deficit values, also had the strongest positive effect. In addition to these parameters, higher wind speeds also had a strong positive effect on SMB occurrence.
Digitalization and Uncertainty in the University: Coherence and Collegiality Through a Metacurriculum
Authors: Johnson Mark William , Suvorova Elena A. , Karelina Alina A. 
Published: July 2022

AbstractRecent initiatives to promote ‘digitalization’ in education exhorting increased digital literacy and ‘computational thinking’ have invited implementation research methods to transform curricula, teaching, and learning. While conceived as a movement from the present of education to an imagined future where envisaged curricula embrace data-oriented and computational practices across subjects, we ask: whose present? Whose future? We revisit the concept of a metacurriculum (first conceived in the 1990s) as a way of addressing this question, while not avoiding the challenges inherent in the adaptation of education to an increasingly complex postdigital environment. We argue that the principal challenge facing institutional and individual adaptation is increasing environmental uncertainty produced by technology, not deficiency in individual skills. Using the uncertainty concept, we present a practical co-designed and dialogical approach supporting the student and teacher journeys towards the transdisciplinary opportunities opened out by technology, based on a cybernetic model of intersubjectivity. We discuss the explanatory power of uncertainty in this context, focusing on the ways it can encourage dialogue, collegiality, and experimentation. Evidence for this is presented in a case study from a Russian University Business School where a large group of teachers co-designed and delivered a dialogical module on digitalization and interdisciplinarity over a period of 4 years—a collaboration ended by recent geopolitical events. In analyzing data from one of the central activities of this course, we focus on the teacher collegiality and the students’ mechanisms of selection in navigating the transdisciplinary space, and how these mechanisms may provide deeper insight into the dialogical underpinnings of education.
The “General Close of Military Operations” as the Benchmark for the Declassification of Armed Conflicts and the End of the Applicability of International Humanitarian Law
Authors: GRIGNON JULIA 
Published: July 2022

AbstractWhen does an armed conflict end? When does the specific body of law applicable to such a situation — namely, international humanitarian law (IHL) — cease to apply? There is, to date, no clear-cut answer to these questions in treaty law but, rather, a functional approach to the matter. Anchored in wider research related to the temporal scope of applicability of IHL, this contribution demonstrates how the notion of the “general close of military operations,” which appears in Article 6, paragraph 2, of Geneva Convention IV and in Article 3(b) of Additional Protocol I, fulfills the function of determining that any armed conflict has ended.
Calabi–Yau properties of Postnikov diagrams
Authors: Pressland Matthew 
Published: July 2022

Abstract
We show that the dimer algebra of a connected Postnikov diagram in the disc is bimodule internally

$3$

-Calabi–Yau in the sense of the author’s earlier work [43]. As a consequence, we obtain an additive categorification of the cluster algebra associated to the diagram, which (after inverting frozen variables) is isomorphic to the homogeneous coordinate ring of a positroid variety in the Grassmannian by a recent result of Galashin and Lam [18]. We show that our categorification can be realised as a full extension closed subcategory of Jensen–King–Su’s Grassmannian cluster category [28], in a way compatible with their bijection between rank

$1$

modules and Plücker coordinates.
Does high-performance work system bring job satisfaction? Exploring the non-linear effect of high-performance work system using the ‘too much of a good thing’ theory
Authors: Yan Liang , Zhao Jing , Zhang Qian , Sass Mary D. 
Published: July 2022

AbstractWe examine the relationship between high-performance work system (HPWS) and job satisfaction, drawing on the ‘too much of a good thing’ theory, to establish whether a non-linear relationship can explain conflicts in previous findings. Moreover, we extend the study by exploring the mediating role of work overload and the moderating role of person–organization fit (P–O fit). Based on a cross-sectional data set of 220 employees and a longitudinal data set of 373 employees from organizations in China, the empirical findings show an invertedU-shaped relationship between HPWS and job satisfaction. Results also indicate that the relationship between HPWS and job satisfaction is fully mediated by work overload, and that P–O fit negatively moderates HPWS-work overload and HPWS-job satisfaction relationships. These results shed new light on how HPWS impacts employee outcomes and practical implications for managers are discussed.
Camel milk consumption patterns and perceptions in the UAE: a cross-sectional study
Authors: Cheikh Ismail Leila , Osaili Tareq M. , Mohamad Maysm N. , Zakaria Hala , Ali Aaesha , Tarek Asma , Ashfaq Alizeh , Al Abdouli Mohamed A. , Saleh Sheima T. , Daour Rameez Al , AlRajaby Radhiya , Stojanovska Lily , Al Dhaheri Ayesha S. 
Published: July 2022

Abstract
Camel milk has been consumed for centuries due to its medicinal and healing properties. The present study aims to investigate the consumption patterns of camel milk and perceived benefits and risks among adults in the United Arab Emirates. A self-administered online questionnaire was developed in English and Arabic languages and was completed online by 852 adults. Socio-demographic characteristics, camel milk consumption patterns and perceived knowledge of the benefits and risks of camel milk were investigated. About 60 % of the participants have tried drinking camel milk, but only a quarter (25⋅1 %) were regular consumers. The most consumed camel milk products after fresh milk were yoghurt and flavoured milk. The most popular additions to camel milk were honey, turmeric and sugar. Most consumers had less than one cup of camel milk per day (57⋅0 %). Camel milk consumers preferred it over other types of milk due to its nutritional value (66⋅4 %) and medicinal properties (39⋅3 %). Among consumers, 58⋅4 % reported consuming unpasteurised camel milk. Reasons included the belief that it is fresher (87⋅2 %), better for the immune system (41⋅6 %), and higher in nutrients (39⋅2 %). Overall, participants had inadequate knowledge about the health benefits of camel milk (7⋅11 ± 5⋅3 out of 25). Males and camel milk consumers had a significantly higher knowledge about the health benefits of camel milk compared to females and non-consumers (P < 0⋅05). Although positive perceptions were common, misperceptions appear to be prevalent among non-consumers. Consuming unpasteurised camel milk is a major public health concern, thus national regulations are essential.
Transcatheter closure of main pulmonary artery pseudoaneurysm using atrial septal occluder device in an infant
Authors: Al-Ata Jameel , Rakha Shaimaa 
Published: July 2022

AbstractWe present a case of percutaneous closure of main pulmonary artery pseudoaneurysm using an atrial septal occluder device in a seven-month-old infant. The infant had tetralogy of Fallot repair followed by transcatheter left pulmonary artery stenting. The occlusion of the wide neck of the pseudoaneurysm was performed successfully using the atrial septal occluder with no detected complications in his six-month follow-up post-catheterisation.
A Mongol in the Cairo Mint?
Authors: KOLBAS JUDITH 
Published: July 2022

AbstractThe name Ilqāy appears on small monetary weights for 1251 and 1252 in Cairo at the beginning of Mamlūk rule. This person was a high official in the treasury, responsible for regulating monetary transactions. However, the name is not Arabic but Mongolian—and at this point, the Mamlūks and Mongols were contesting the Middle East. This article traces the meaning of the unique name and its appearance in Mongol history. It then discusses the hypothetical way in which Ilqāy developed Mongol coinage in his early career. The violent purges of the Mongol civil war may have forced him to escape and enter Egypt's financial system. This biography is hypothetical since there is no literary evidence for mint activity and personnel at this time. Nevertheless, the unusual name and timing create a mystery that invites special consideration.