bluuebunny/crossref_metadata_2025_split huggingface dataset:
Kidney Biopsy Features Most Predictive of Clinical Outcomes in the Spectrum of Minimal Change Disease and Focal Segmental Glomerulosclerosis
Authors: Zee Jarcy , Liu Qian , Smith Abigail R. , Hodgin Jeffrey B. , Rosenberg Avi , Gillespie Brenda W. , Holzman Lawrence B. , Barisoni Laura , Mariani Laura H. 
Published: May 2022

Significance Statement
The classification of podocytopathies, including minimal change disease (MCD) and focal segmental glomerulosclerosis (FSGS), has historically been based on limited glomerular features. This study used supervised machine learning methods to identify the most important clinical and histopathologic predictors of disease progression, complete proteinuria remission, and treatment response in MCD/FSGS. The top predictors included conventional and novel glomerular and tubulointerstitial features. Biopsy reporting for podocytopathies should be standardized by including these prognostic morphologic features to inform risk stratification.

Background
Heterogeneity in disease course and treatment response among patients with MCD/FSGS necessitates a granular evaluation of kidney tissue features. This study aimed to identify histologic and ultrastructural descriptors of structural changes most predictive of clinical outcomes in the Nephrotic Syndrome Study Network (NEPTUNE).

Methods
Forty-eight histologic (37 glomerular, 9 tubulointerstitial, 2 vascular) and 20 ultrastructural descriptors were quantified by applying the NEPTUNE Digital Pathology Scoring System to NEPTUNE kidney biopsies. Outcomes included time from biopsy to disease progression, first complete remission of proteinuria, and treatment response. Relative importance of pathology and clinical predictors was obtained from random forest models, and predictive discrimination was assessed.

Results
Among 224 participants (34% Black, 24% Hispanic), model performance was excellent, with predictive discrimination of 0.9 for disease progression, 0.85 for complete remission, and 0.81 for treatment response. The most predictive descriptors of outcomes included both conventional—e.g., global sclerosis or segmental sclerosis and interstitial fibrosis/tubular atrophy—and novel features, including adhesion, interstitial foam cells, deflation, periglomerular fibrosis, mononuclear white blood cells, endothelial cell abnormalities, microvillous transformation, and acute tubular injury.

Conclusions
The most predictive descriptors of clinical outcomes among MCD/FSGS patients reflected structural changes in multiple renal compartments. Reporting these descriptors should be standardized to guide prognostication of proteinuric glomerular diseases.
Giracardio: jogo educativo para a promoção à saúde cardiovascular em feirantes
Authors: Teixeira de Sousa Santos Lucas , Cardoso da Frota Kairo , Canafistula de Souza Francisco Douglas , De Azevedo Ponte Keila Maria 
Published: May 2022

OBJETIVOS: descrever o processo de elaboração do jogo educativo GIRACARDIO para a promoção à saúde cardiovascular em feirantes e relatar as impressões desse público acerca da aplicabilidade da tecnologia educativa. MÉTODOS: Trata-se de uma pesquisa de multimétodos, realizada no mês de fevereiro de 2020 no Mercado Público de Sobral-Ceará, com uma amostra final de vinte feirantes. A coleta realizou-se por meio da aplicação da tecnologia educativa e a utilização de um questionário de qualidade de vida. O tratamento dos dados se deu por meio da análise temática de conteúdo. RESULTADOS: Houve uma aderência significativa pelo público durante a aplicação da tecnologia educativa facilitando o momento de educação em saúde com base no favorecimento de hábitos saudáveis e alerta para riscos cardiovasculares. O giracardio configurou-se como um instrumento facilitador de ensino-aprendizagem, contribuindo para uma educação em saúde diferente das tradicionais, e apontou benefícios na utilização de jogos educativos pela enfermagem. CONCLUSÃO: A aplicação do Giracardio favoreceu o ensino-aprendizado, o que levou uma avaliação positiva da tecnologia educativa pelo público alvo. Para a enfermagem, a pesquisa agregou cientificidade sobre os benefícios da utilização de tecnologias leves no cuidado à saúde, com foco nos jogos educativos.
Кто такие представители гражданской науки: размышления о терминологии и вопросы о самоидентификации
Authors: Лаврентьева Софья Всеволодовна 
Published: May 2022

<p>Целью данной статьи является поиск опорных точек на пути к ответу на следующие вопросы: 1) На что мы можем опираться, когда говорим о людях, занимающихся гражданской наукой? 2) Какие характеристики являются значимыми для их (само)определения? Данные вопросы разделены на три части: как сами гражданские ученые воспринимают себя; как видит гражданских ученых официальная наука; как идентифицирует их общественность.</p><p>В первой части инструментом для анализа особенностей самоопределения гражданских ученых выступает концепция нарративной идентичности Дэниела Деннета. Показано, что представители гражданской науки ищут элементы, которые позволяют говорить об общности гражданской науки. Таковыми являются подход к распространению и получению новых знаний. Второй раздел показывает, что основным элементом при рассмотрении фигуры ученого с точки зрения институциональной науки являются, с одной стороны, дефицит научных знаний, а с другой стороны, — недостаток научной ответственности. В третьей части показано, как внеинституциональность и децентрализация, изначально касающиеся распространения и производства знаний в гражданской науке, сказались на отсутствии регуляции в том, кто обозначает себя «биохакером» и относит себя к гражданской науке.</p>
Perception of telemedicine and eHealth technology for cancer care in north east India: A survey in Arunachal Pradesh
Authors: Kumar Chaitan , Singh M Momocha 
Published: May 2022

The epidemiological burden of cancer is higher in the North Eastern region than other part of India. Papumpare register in Arunachal Pradesh has the highest age-adjusted rate of female cancer and the second highest rate of male cancer among all Indian registers. Arunachal Pradesh has only one tertiary care facility, and most cancer patients are sent to other states for treatment. The purpose of this study was to determine the scope of Telemedicine and people's perceptions on the use of digital health services. Data from secondary sources and an online survey with 565 responses were analysed.More than half of the respondents have a favourable attitude toward digital health, use of internet services, and trust in telemedicine. Improving digital infrastructure and raising public knowledge about the use of eHealth services is a pressing need. Telemedicine has the potential to improve the health-care system in the north-eastern area by reducing outward migration and lowering the economic cost of treatment.
Dimensions of Being a Midwife and Midwifery Practice in the United States: A Qualitative Analysis
Authors: Thumm E. Brie , Stimpfel Amy Witkoski , Squires Allison 
Published: May 2022

BACKGROUNDMidwives are a vital component of addressing maternal mortality crisis in the United States (US); however, there is scant understanding of the elements of midwifery practice that affect patient outcomes and the stability of the midwifery workforce in the country. This study investigates US midwives’ perceptions of factors influencing their practice and willingness to stay in the profession.METHODSWe applied a pragmatic qualitative design using summative content analysis techniques to code 1,035 comments from a national sample of 2,887 certified nurse-midwives and certified midwives. Two coders identified categories and themes of midwives’ perceptions of their practice environments, which were confirmed by an independent auditor.RESULTSEight themes emerged from the data: I love midwifery but…; feeling valued and respected…or not; workload; time and its consequences; the multilevel geography of midwifery practice; changes at odds with quality midwifery care; midwives withdrawing from practice to cope; and the ambiguity of “I just want to practice like a midwife.”CONCLUSIONMidwives readily identified aspects of their practice environment that negatively impact quality of care and stability of the midwifery workforce, including not valuing midwives, high workload, regulatory restrictions, and moral distress; however, respondents expressed strong commitment to the profession of midwifery. The findings also demonstrated the lack of a universally accepted definition of midwifery care within respondents’ professional communities and among respondents. Initiatives to increase integration of midwifery into the US perinatal health system will benefit from taking these findings into consideration.
Reducing Hospital Admissions for Patients With Heart Failure by Implementing the Chronic Care Management Framework: A Cost, Quality, and Satisfaction Improvement Project
Authors: Koutlas Alexis , Jenkins Peggy 
Published: May 2022

ObjectiveTo reduce the rate of hospital admissions, and increase the perception of coordinated care for patients with heart failure and associated co-morbidities through improvement of interdisciplinary communication.BackgroundHeart failure patients with associated multi-morbidities and multiple provider visits are often left to navigate the health system independently. Limited provider to provider communication contributes to care fragmentation, unnecessary utilization and decreased satisfaction.MethodsA nurse-led complex care management improvement project imbedded care plans and formal and informal collaborative care conferences to improve interprofessional communication across the care continuum.ResultsHospital admissions decreased by 62% and length of stay decreased by 73% (n = 47, p < .001). Using paired t-test, satisfaction questions improved post intervention, and one was statistically significant (p < 0.05).ConclusionImproved communication strategies decreased hospital admissions and length of stay in one large Pacific Northwest health system. Days subject to readmission penalties decreased by 98% with a variance in pre-post charges of $615,000.Implication for NursesNurses and nurse leaders play a significant role in achieving the Triple Aim and can be instrumental in developing small multidisciplinary teams targeting improved coordination across settings and sectors.
Borsa İstanbul’da İçeriden Öğrenenlerin Getirileri
Authors: UNAL Serkan 
Published: May 2022

Amaç: Bu çalışmada Borsa İstanbul’da içeriden öğrenenlerin işlem yaptığı hisselerin performansları analiz edilmiştir.
Tasarım/Yöntem: Araştırmada 2015 ve 2020 yılları arasında içeriden öğrenenler tarafından KAP’a sunulan 2131 adet bildirim indirilmiştir. t testleri vasıtasıyla bu bildirimlere konu olan hisselerin performansları analiz edilmiştir.
Bulgular: İçeriden öğrenenler piyasayı etkin bir şekilde zamanlayabilmektedirler. Genellikle düşük performans göstermiş hisseleri almakta ve yüksek performans göstermiş hisseleri satmaktadırlar. Alım tutarlarının yüksekliği ile elde ettikleri performans arasında anlamlı bir ilişki bulunmamaktadır. Davranışsal olarak yüksek performans gösteren hisseleri satma, düşük performans gösteren hisseleri ise alma yönünde yanlılık göstermektedirler.
Sınırlılıklar: Araştırma yalnızca BIST100 hisselerini ve 2015-2020 zaman aralığını kapsamaktadır.
Özgünlük/Değer: Çalışmanın dönemi, 15 Temmuz 2016 darbe girişimi, 2018 Ağustosundaki kur şoku ve sermaye piyasalarında 2020 yılı Mart ayında Covid 19 nedeniyle yaşanan sert düşüş gibi önemli olayları kapsamaktadır. Bu sayede içeriden öğrenen işlemlerinin değişik piyasa şartlarında değerlendirilebilmesi mümkün olmaktadır. Ayrıca içeriden öğrenen işlemlerinde, geçmiş hisse performanslarının oluşturduğu yanlılık etkisi de incelenmiştir.
Progressive Development of a Distributed Ductile Shear Zone beneath the Patagonian Retroarc Fold-Thrust Belt, Chile
Authors: Betka Paul , Mosher Sharon , Klepeis Keith 
Published: May 2022

Abstract
The southern Patagonian Andes record Late Cretaceous–Paleogene compressional inversion of the Rocas Verdes backarc basin (RVB) and development of the Patagonian fold-thrust belt (FTB). A ductile décollement formed in the middle crust and accommodated underthrusting, thickening, and tectonic burial of the continental margin (Cordillera Darwin Metamorphic Complex (CDMC)) beneath the RVB. We present new geologic mapping, quartz microstructure, and crystallographic preferred orientation (CPO) fabric analyses to document the kinematic evolution and deformation conditions of the décollement. Within the CDMC, the décollement is defined by a quartz/chlorite composite schistose foliation (S1-2) that is progressively refolded by two generations of noncylindrical, tight, and isoclinal folds (F3–F4). Strain intensifies near the top of the CDMC, forming a &gt;5 km thick shear zone that is defined by a penetrative L-S tectonite (S2/L2) and progressive noncylindrical folding (F3). Younger kink folds and steeply inclined tight folds (F4) with both north- and south-­dipping axial planes (S4) overprint D2 and D3 structures. Quartz textures from D2 fabrics show subgrain rotation and grain boundary migration recrystallization equivalent to regime 3, and quartz CPO patterns indicate mixed prism &lt;a&gt; and [c] slip systems with c-axis opening angles indicative of deformation temperatures between ~500° and &gt;650°C. Approximately 40 km toward the foreland, the shear zone thins (~1 km thick) and is defined by the L-S tectonite (S2/L2) and tightening of recumbent isoclinal folds (F3). Quartz textures and CPO patterns indicate subgrain rotation recrystallization typical of regime 2 and dominantly basal &lt;a&gt; slip, and c-axis opening angles are consistent with deformation temperatures between ~375° and 575°C. Deformation occurred under greenschist and amphibolite facies conditions in the foreland and hinterland, respectively, indicating that the shear zone dipped shallowly toward the hinterland. The Magallanes décollement is an example of a regional ductile shear zone that accommodated distributed middle to lower crustal thickening below a retroarc FTB.
Nomogram predicting overall survival after surgical resection for retroperitoneal leiomyosarcoma patients
Authors: Zhuang Aobo , Zhang Yong , Fang Yuan , Ma Lijie , Lu Weiqi , Tong Hanxing , Zhuang Rongyuan , Wang Zhiming , Ding Yuqin , Ji Zhengbiao , Wang Yichao , Zhang Li , Yang Jue , luo Rongkui , Yang Hua , Zhou Yuhong 
Published: May 2022

Abstract
Background
Surgery is the best way to cure the retroperitoneal leiomyosarcoma (RLMS), and there is currently no prediction model on RLMS after surgical resection. The objective of this study was to develop a nomogram to predict the overall survival (OS) of patients with RLMS after surgical resection.
Methods
Patients who underwent surgical resection from September 2010 to December 2020 were included. The nomogram was constructed based on the COX regression model, and the discrimination was assessed using the concordance index. The predicted OS and actual OS were evaluated with the assistance of calibration plots.
Results
118 patients were included. The median OS for all patients was 47.8 (95% confidence interval (CI), 35.9–59.7) months. Most tumor were completely resected (n = 106, 89.8%). The proportions of French National Federation of Comprehensive Cancer Centres (FNCLCC) classification were equal as grade 1, grade 2, and grade 3 (31.4%, 30.5%, and 38.1%, respectively). The tumor diameter of 73.7% (n = 85) patients was greater than 5 cm, the lesions of 23.7% (n = 28) were multifocal, and 55.1% (n = 65) patients had more than one organ resected. The OS nomogram was constructed based on the number of resected organs, tumor diameter, FNCLCC grade, and multifocal lesions. The concordance index of the nomogram was 0.779 (95% CI, 0.659–0.898), the predicted OS and actual OS were in good fitness in calibration curves.
Conclusion
The nomogram prediction model established in this study is helpful for postoperative consultation and the selection of patients for clinical trial enrollment.
Pollutant emissions in livestock buildings: influence of indoor environment, rearing systems, and manure management
Authors: Andrade Leonardo de Brito , Martín-Gómez César , Zuazua-Ros Amaia , Ariño Arturo H. 
Published: May 2022

Abstract
The issue of air pollutants from livestock buildings is prevalent in the literature. Because they and their emissions impact both animal production and livestock building users as well as the outdoor environment. This paper aims to compile and review data available in the scientific literature on the types of pollutants for a better understanding of their generation form, their distribution according to the kind of animal, and the main factors affecting their generation and concentration, i.e., the rearing system, the indoor microclimate, and the manure management. The elevated generation of pollutants in animal buildings is tied to the dense occupancy in this industrial activity. The indoor air quality is defined according to the type of livestock in animal housing, considering its welfare needs, and the types and concentrations of pollutants generated as a function of the family of animal and the management used in production. The main gases generated are CH4, CO2, H2S, NH3, N2O, in addition to particulate matter and airborne microorganisms such as fungi and bacteria that very negatively affect the health of animals and users of the animal buildings. Furthermore, knowledge about the main contaminants generated, the form of generation, their origin, their concentrations, and their distribution throughout the shed is essential to achieve a permanent and adequate indoor air quality and, with that, a high-quality product that will lead to high production yield without neglecting animal welfare.
Third-generation cephalosporin resistant gram-negative bacteraemia in patients with haematological malignancy; the value of a surveillance-culture-guided empirical therapy approach
Authors: Court Jara R. de la , Woudt Sjoukje H. S. , Schoffelen Annelot F. , Heijmans Jarom , de Jonge Nick A. , Bruggen Tjomme van der , Bomers Marije K. , Lambregts Merel M. C. , Schade Rogier P. , Sigaloff Kim C.E. 
Published: May 2022

Abstract
ObjectivesAmong patients with haematological malignancy, bacteraemia is a common complication during chemotherapy-induced neutropenia. Resistance of gram-negative pathogens to third-generation cephalosporins is increasing. We aimed to provide rationale for surveillance-culture-guided (SCG) empirical therapy for this population.MethodsUsing 11 years of data (2008-2018) from the Dutch national antimicrobial resistance surveillance system, we assessed the prevalence of third-generation cephalosporin resistant Gram-negative bacteria (3GCR-GNB) in episodes of bacteraemia, and the proportion of 3GCR-GNB bacteraemia that was preceded by 3GCR-GNB colonization (identified using surveillance cultures) in the year before.ResultsWe included 3,887 patients, representing 4,142 episodes of bacteraemia. GNB were identified in 715/4,142 (17.3%), of which 221 (30.9%) were 3GCR-GNB. In (106/139) 76.2% of patients with a 3GCR-GNB bacteraemia and available GNB surveillance cultures in the preceding year, 3GCR-GNB colonization had been previously identified.ConclusionsThis multi-centre study shows that in patients with haematological malignancy, the majority of 3GCR-GNB bacteraemia is preceded by 3GCR-GNB colonization. This approach thereby reduces the risk of inappropriately treated 3GCR-GNB bacteraemia without the necessity to administer carbapenems to all high-risk neutropenic patients with fever.
Modeling of Inversion Layer Capacitance of III-V Double Gate MOSFETs using Neural Network based Regression Technique
Authors: Maity Subir Kumar , Pandit Soumya 
Published: May 2022

Abstract
This work presents a data-driven regression model of inversion layer capacitance of double gate III-V channel MOSFETs implemented using an artificial neural network. The training dataset is generated using a Schroedinger-Poisson solver for different channel thicknesses, carrier effective masses, oxide thickness, barrier height, and a wide range of gate bias voltages. The neural network predicted capacitance value is compared with Schroedinger-Poisson solver data and a physics-based analytical model result. The model effectively captures the variation in channel thickness, barrier height, carrier effective mass, and oxide thickness. Furthermore, extensive error analysis has been performed to demonstrate the correctness and degree of accuracy of the predicted result.
Exponential Stability for the T-S Fuzzy Systems with Distributed Time Delays under Quantization
Authors: Aslam Muhammad Shamrooz 
Published: May 2022

Abstract
A nonlinear system with distributed delays is investigated in this study under the quantization effect. A new fuzzy filter, as opposed to the existing one, receives both the quantized delay output and the quantized output of the system. It is the aim of this research to design a delay fuzzy filter to ensure that the considered error system satisfies an H ∞ performance index with a time–varying delay under quantization features. Using a new version of the Lyapunov–Krasovskii-functional as a starting point, we derive sufficient conditions at which the filtering error system is stable and performs well. Therefore, linear matrix inequalities (LMIs) are derived as a theory for determining whether desired filters exist under delay-dependent and decay-rate-dependent conditions. The filter coefficients can be calculated with feasible solutions of the LMIs . The proposed method is illustrated by a numerical example as a demonstration of its effectiveness.