bluuebunny/crossref_metadata_2025_split huggingface dataset:
Competing logics and reform strategies in local reform: A case study of administrative licensing reform in China
Authors: Yang Zhenjie , Liang Yuqing , Yu Mengyan 
Published: November 2022

AbstractHow to balance the market and the government to promote local economic development and provide sufficient public services has always been a challenging issue for leaders, in face of the existence of varied interests and values of different stakeholders. Conflicting values between the market and the government are directly related to the competing logics between market orientation and bureaucratic/administrative dominance. Since China's transition from the planned economy or government dominance to marketization in 1978, a series of national and local innovations has been launched. Among those reforms, policy entrepreneurs played a critical role. Administrative licensing reform was one of key changes from the planned economy to the marketized economy. Through a local case in administrative licensing reform, this study explores how a policy entrepreneur at local level applied reform strategies to balance conflicting values and constrain the self‐interested bureaucracy to achieve the marketization reform.
A semiparametric joint model for cluster size and subunit‐specific interval‐censored outcomes
Authors: Lee Chun Yin , Wong Kin Yau , Lam Kwok Fai , Bandyopadhyay Dipankar 
Published: November 2022

AbstractClustered data frequently arise in biomedical studies, where observations, or subunits, measured within a cluster are associated. The cluster size is said to be informative, if the outcome variable is associated with the number of subunits in a cluster. In most existing work, the informative cluster size issue is handled by marginal approaches based on within‐cluster resampling, or cluster‐weighted generalized estimating equations. Although these approaches yield consistent estimation of the marginal models, they do not allow estimation of within‐cluster associations and are generally inefficient. In this paper, we propose a semiparametric joint model for clustered interval‐censored event time data with informative cluster size. We use a random effect to account for the association among event times of the same cluster as well as the association between event times and the cluster size. For estimation, we propose a sieve maximum likelihood approach and devise a computationally‐efficient expectation‐maximization algorithm for implementation. The estimators are shown to be strongly consistent, with the Euclidean components being asymptotically normal and achieving semiparametric efficiency. Extensive simulation studies are conducted to evaluate the finite‐sample performance, efficiency and robustness of the proposed method. We also illustrate our method via application to a motivating periodontal disease dataset.
A review of state regulations for child care: Preventing, recognizing and reporting child maltreatment
Authors: Grossman Elyse R. , McClendon Jasmine E. , Gielen Andrea C. , McDonald Eileen M. , Benjamin‐Neelon Sara E. 
Published: November 2022

AbstractBackgroundPrior to the COVID‐19 pandemic, nearly 60% of children under 5 years of age were cared for in out‐of‐home child care arrangements in the United States. Thus, child care provides an opportunity to identify and address potential child maltreatment. However, during the pandemic, rates of reporting child maltreatment decreased—likely because children spent less time in the presence of mandated reporters. As children return to child care, states must have regulations in place to help child care providers prevent, recognize and report child maltreatment. However, little is known about the extent to which state regulations address child maltreatment. Therefore, the purpose of this cross‐sectional study was to assess state regulations related to child maltreatment and compare them to national standards.MethodWe reviewed state regulations for all 50 states and the District of Columbia for child care centres (‘centres’) and family child care homes (‘homes’) through 31 July 2021 and compared these regulations to eight national health and safety standards on child maltreatment. We coded regulations as either not meeting, partially meeting or fully meeting each standard.ResultsThree states (Colorado, Utah and Washington) had regulations for centres, and one state (Washington) had regulations for homes that at least partially met all eight national standards. Nearly all states had regulations consistent with the standards requiring that caregivers and teachers are mandated reporters of child maltreatment and requiring that they be trained in preventing, recognizing and reporting child maltreatment. One state (Hawaii) did not have regulations consistent with any of the national standards for either centres or homes.ConclusionsGenerally, states lacked regulations related to the prevention, recognition and reporting of child maltreatment for both centres and homes. Encouraging states to adopt regulations that meet national standards and further exploring their impact on child welfare are important next steps.
Auditory–limbic–cerebellum interactions and cognitive impairments in noise‐induced hearing loss
Authors: Xu Xiao‐Min , Feng Yuan , Wang Jian , Salvi Richard , Yin Xindao , Gao Jun , Chen Yu‐Chen 
Published: November 2022

AbstractAimsThis study aimed to explore the neural substrate of hearing loss‐related central nervous system in rats and its correlation with cognition.MethodsWe identified the neural mechanism for these debilitating abnormalities by inducing a bilateral hearing loss animal model using intense broadband noise (122 dB of broadband noise for 2 h) and used the Morris water maze test to characterize the behavioral changes at 6 months post‐noise exposure. Functional magnetic resonance imaging (fMRI) was conducted to clarify disrupted functional network using bilateral auditory cortex (ACx) as a seed. Structural diffusion tensor imaging (DTI) was applied to illustrate characteristics of fibers in ACx and hippocampus. Pearson correlation was computed behavioral tests and other features.ResultsA deficit in spatial learning/memory, body weight, and negative correlation between them was observed. Functional connectivity revealed weakened coupling within the ACx and inferior colliculus, lateral lemniscus, the primary motor cortex, the olfactory tubercle, hippocampus, and the paraflocculus lobe of the cerebellum. The fiber number and mean length of ACx and different hippocampal subregions were also damaged in hearing loss rats.ConclusionA new model of auditory–limbic–cerebellum interactions accounting for noise‐induced hearing loss and cognitive impairments is proposed.
Preliminary feasibility of animated video education designed to empower patients’ referral to kidney transplantation
Authors: Kayler Liise K. , Keller Maria M. , Breckenridge Barbara , Feeley Thomas H. , Suboh Jamal , Tumiel‐Berhalter Laurene 
Published: November 2022

AbstractBackgroundReferral for kidney transplantation is influenced by patient education; digital technologies can enhance broad information accessibility. This single‐group study tested the feasibility and acceptability of patient‐centered self‐directed educational animated videos to improve mediators of kidney transplant referral.MethodsCommunity‐based adults with chronic kidney disease stage ≥4 invited from a clinical registry or self‐responding to flyers viewed eight sequential videos (19:36 min total duration) remotely on their own device. Change in kidney transplant knowledge, concerns, and confidence talking about kidney transplantation to doctors was assessed with self‐report surveys before and immediately after viewing. Program feedback was assessed by survey and self‐selected exit interview.ResultsViewers of the video set (n = 50) demonstrated increases in mean kidney transplantation knowledge by +22%, confidence discussing with their doctor by +6%, and reductions in concerns by ‐2%. Knowledge results were consistent across age, race, and literacy level. Over 90% indicated positive ratings on understanding, engaging, and helpfulness. In post‐study interviews viewers indicated the videos promoted confidence in obtaining a kidney transplant and none reported that the 19‐min duration of the home education was too long.ConclusionThe animated video education is promising to improve diverse individuals’ knowledge, concerns, and communication confidence about kidney transplantation and is highly acceptable.
A retrospective chart review of trauma‐related documentation in an Australian substance use treatment service
Authors: Harvey Logan R. , Hopkins Rachel , Truscott Melanie , Marel Christina , Slade Tim , Mills Katherine L. 
Published: November 2022

AbstractIntroductionTrauma exposure among clients of substance use treatment services is almost universal and rates of trauma‐related symptoms are correspondingly high. This study examined one aspect of clinical care—clinical documentation—and sought to systematically assess the documentation of trauma‐related comorbidities and their treatment in a substance use treatment setting.MethodsA retrospective chart review was conducted on a sample of 300 patient records in a public substance use treatment setting. Rates of documentation of trauma‐related events, symptoms and treatment, along with variables influencing the documentation of these issues, were examined.ResultsTrauma‐related documentation was present in 45.3% of records. There were documented trauma‐related symptoms in 15.3% of records, although treatment activities addressing trauma were only present in 2.3% of records. Being female (odds ratio [OR] 2.58, 95% confidence interval [CI] 1.42, 4.69), having prior mental health treatment (OR 1.82, 95% CI 1.05, 1.12) and having more treatment sessions (OR 1.08, 95% CI = 1.05, 1.12) increased the odds of trauma‐related documentation being present, while being in the first episode of treatment (OR 0.49, 95% CI = 0.28, 0.84) decreased the odds.Discussion and ConclusionsThis study highlights significant under documentation of trauma‐related comorbidities in substance‐use treatment. There is limited evidence of consideration of trauma‐related symptoms or diagnoses, and trauma‐related comorbidities are rarely included in treatment planning activities. The lack of documented trauma‐related information has important clinical and medico‐legal implications for patients, and provides evidence to suggest a lack of integration of treatment for trauma‐related disorders in substance use settings.
Analysis of online rebates and commission formats in a retailer‐Stackelberg supply chain with cashback website
Authors: Xu Peng , Xiao Tiaojun 
Published: November 2022

AbstractMotivated by the fact that many e‐tailers offer online rebates through cashback websites to attract more consumers, and wield channel leadership, we construct a retailer‐Stackelberg supply chain comprised of one e‐tailer, one manufacturer, and one cashback website. Cashback websites have two commission formats: sharing and fixed. We first explore the online rebate strategy of the e‐tailer (under the two commission formats); and then study the e‐tailer's commission format selection strategy when offering rebates. Our analysis reveals that: (i) the product valuation and fraction of low‐end consumers play key roles in shaping the e‐tailer's online rebate and commission format selection strategies; (ii) the e‐tailer's rebates increase the wholesale price under sharing commission, but decrease it under fixed commission; (iii) the e‐tailer's rebates may be a trap for consumers because they may pay a higher retail price after rebates; (iv) under both commissions, the e‐tailer's rebates hurt the manufacturer, but could enhance supply chain performance; and (v) when offering rebates, low‐end consumers and the manufacturer are better off under sharing commission if its product valuation is sufficiently low, while high‐end consumers are better off under fixed commission. Additionally, the e‐tailer has a stronger incentive to provide rebates when the manufacturer acts as the leader; temporary rebate promotion may lead to a triple win situation for the manufacturer, e‐tailer, and consumers.
A prediction model based on functional mitral regurgitation for the recurrence of paroxysmal atrial fibrillation (PAF) after post‐circular pulmonary vein radiofrequency ablation (CPVA)
Authors: Sheng Jingyu , Yang Zhenni , Xu Min , Meng Jun , Gong Mingxia , Miao Yuxia 
Published: November 2022

AbstractAimTo construct a prediction model based on functional mitral regurgitation (FMR) in patients with paroxysmal atrial fibrillation (PAF) to predict atrial fibrillation recurrence after the post‐circular pulmonary vein radiofrequency ablation (CPVA).MethodsWe retrospectively analyzed 289 patients with PAF who underwent CPVA for the first time. The patients were randomly divided into modeling group and verification group at the ratio of 75:25. In the modeling group, the multivariate logistic regression was used to analyze and construct a prediction model for post‐CPVA recurrence in PAF patients, which was then validated in the verification group.Results(1) After 3–6 months of follow‐up, the patients were divided into sinus rhythm group (252 cases) and recurrence group (24 cases); (2) In the modeling group, the age, left atrial diameter (LAD), and the degree of MR (mild, moderate, severe) were higher in recurrence group than that of the sinus rhythm group, and the left atrial appendage emptying velocity (LAAV) was lower in recurrence group (all p < .05). (3) A model for predicting the recurrence of PAF after radiofrequency ablation was constructed in the modeling group. The equation was: Logit(P) = −3.253 + .092 × age + 1.263 × mild MR + 2.325 × moderate MR + 5.111 × severe MR −.113 × LAAV. The area under the curve (AUC) of the model was .889 in modeling group and .866 in verification group, and the difference was not statistically significant (p > .05).ConclusionThe prediction model of atrial fibrillation (AF) recurrence after CPVA in PAF patients has good predictive efficacy, specificity, and accuracy.
Reference change value of global longitudinal strain in clinical practice: A test‐retest quality implementation project
Authors: Tuzovic Mirela , Tang Xiu , Francisco Nadia , Sell April , Drew Robert , Paloma Allan , Chow Judy , Liang David , Heidenreich Paul , Salerno Michael , Schnittger Ingela , Haddad Francois 
Published: November 2022

AbstractBackgroundReference change value (RCV) is used to assess the significance of the difference between two measurements after accounting for pre‐analytic, analytic, and within‐subject variability. The objective of the current study was to define the RCV for global longitudinal strain (GLS) using different semi‐automated software in standard clinical practice.MethodsUsing a test‐retest study design, we quantified the median coefficient of variation (CV) for GLS using AutoStrain and Automated Cardiac Motion Quantification (aCMQ) by Philips. Triplane left‐ventricular ejection fraction (LVEF) was measured for comparison. Multivariable regression analysis was performed to determine factors influencing test‐retest CV including image quality and the presence of segmental wall motion abnormalities (WMA). RCV was reported using a standard formula assuming two standard deviations for repeated measurements; results were also translated into Bayesian probability. Total measurement variation was described in terms of its three different components: pre‐analytic (acquisition), analytic (measuring variation), and within‐subject (biological) variation.ResultOf the 44 individuals who were screened, 41 had adequate quality for strain quantification. The mean age of the cohort was 56.4 ± 16.8 years, 41% female, LVEF was 55.8 ± 9.8% and the median and interquartile range for LV GLS was −17.2 [−19.3 to −14.8]%. Autostrain was more time efficient (80% less analysis time) and had a lower total median CV than aCMQ (CV = 7.4% vs. 17.6%, p < .001). The total CV was higher in patients with WMA (6.4% vs. 13.2%, p = .035). In non‐segmental disease, the CV translates to a RCV of 15% (corresponding to a probability of real change of 80%). Assuming a within‐subject variability of 4.0%, the component analysis identified that inter‐reader variability accounts for 3.7% of the CV, while acquisition variability accounts for 4.0%.ConclusionUsing test‐retest analysis and CVs, we find that an RCV of 15% for GLS represents an optimistic estimate in routine clinical practice. Based on our results, a higher RCV of 17%–21% is needed in order to provide a high probability of clinically meaningful change in GLS in all comers. The methodology presented here for determining measurement reproducibility and RCVs is easily translatable into clinical practice for any imaging parameter.
Association of resting left ventricular global longitudinal strain with myocardial perfusion abnormalities evaluated by 13N‐ammonia positron emission tomography in patients with stable angina pectoris and normal left ventricular ejection fraction
Authors: Yamabe Sayuri , Yamada Akira , Kawada Yuka , Ueda Sayano , Hoshino Naoki , Hoshino Meiko , Takada Kayoko , Sakaguchi Eirin , Ito Ryuta , Kakuno Motohiko , Sakakibara Takashi , Ohshima Satoru , Sarai Masayoshi , Izawa Hideo 
Published: November 2022

AbstractAimsLittle is known about whether resting left ventricular global longitudinal strain (GLS) impairment is associated with myocardial perfusion abnormalities evaluated using 13N‐ammonia positron emission tomography (13N‐NH3‐PET)‐myocardial perfusion imaging (MPI). This study aimed to investigate the correlation between resting GLS and myocardial perfusion parameters in patients with a normal left ventricular ejection fraction (LVEF). We evaluated whether resting GLS can predict myocardial perfusion abnormalities in these patients.Methods and ResultsWe selected 157 patients with suspected stable angina pectoris who underwent both ATP‐stress NH3‐PET‐MPI and 2‐dimentional speckle tracing echocardiography. All subjects had a preserved LVEF and no known history of myocardial infarction. Patients were stratified into Group N (normal perfusion; summed stress score [SSS], 0–3; n = 101), Group M (mildly to moderately abnormal perfusion; SSS, 4–11; n = 41), or Group S (severely abnormal perfusion; SSS, 12+; n = 15). GLS was more impaired as myocardial perfusion abnormality severity increased (–17.9 ± 2.9% for Group N, –16.8 ± 3.1% for Group M, and –14.2 ± 3.5% for Group S; p < .001). GLS was weakly but significantly correlated with SSS (R = .32, p < .001), summed difference score (R = .32, p < .001), and myocardial blood flow during stress (R = –0.27, p < .001). Multivariate logistic regression analysis showed that male sex, diabetes mellitus, systolic blood pressure, and GLS were independent predictors of myocardial perfusion abnormality defined as Groups M and S. Additionally, the area under the curve for GLS for detecting myocardial perfusion abnormality was .65, and the optimal cutoff value for GLS was –16.5%, with sensitivity and specificity of 59% and 66%, respectively.ConclusionIn patients with suspected angina pectoris, resting GLS impairment despite a normal LVEF might aid the detection of hemodynamically significant coronary artery disease.
A novel anatomic classification to guide transcatheter aortic valve replacement for pure aortic regurgitation
Authors: Chen Yang , Lu Zhi‐Nan , Yao Jing , Wang Mo‐yang , Niu Guan‐Nan , Zhang Hong‐Liang , Liu Qing‐Rong , Zhao Jie , Zhao Zhen‐Yan , Perrin Nils , Modine Thomas , Wu Yong‐Jian , Song Guang‐Yuan 
Published: November 2022

AbstractBackgroundThe success of transcatheter aortic valve replacement (TAVR) in native aortic regurgitation (AR) is limited by the absence of calcified anchoring structures. We sought to evaluate transfemoral TAVR in patients with native AR using a novel aortic root imaging classification.MethodsFrom March to November 2021, 81 patients with severe AR were prospectively enrolled in 2 cardiac centers in China. All were evaluated using multidetector computed tomography (MDCT) and classified into 4 anatomic types in reference to transcatheter heart valve (THV) anchoring: Type 1: anchoring at the left ventricular outflow tract (LVOT), annulus, and ascending aorta (AA); Type 2: anchoring at the annulus and AA; Type 3: anchoring at the annulus and LVOT; and Type 4: anchoring at only 1 level or none at all. Based on the dual‐anchoring strategy, patients with Types 1–3 were considered TAVR candidates. Procedural and 30‐day outcomes were assessed according to Valve Academic Research Consortium‐3 definitions.ResultsTAVR was performed in 32 (39.5%) patients (71.9 ± 8.0 years of age, 71.9% were male) using 2 self‐expanding THVs. Types 1, 2, and 3 comprised 13 (40.6%), 11 (34.4%), and 8 (25.0%) cases, respectively. The procedural and device success rates were 100% and 93.8%, respectively, with 2 THV migration. Eight patients (25.0%) required a permanent pacemaker, and 2 (6.3%) developed moderate paravalvular leaks. No deaths or other major complications occurred during the study.ConclusionsThe novel anatomic classification and dual‐anchoring strategy were associated with a high procedural success rate with favorable short‐term safety and clinical outcomes.
Left atrial strain quantified after myocardial infarction is associated with early left ventricular remodeling
Authors: Legallois Damien , Hodzic Amir , Milliez Paul , Manrique Alain , Dolladille Charles , Saloux Eric , Beygui Farzin 
Published: November 2022

AbstractBackgroundLeft ventricular remodeling (LVR) is common and associated with adverse outcome after ST‐elevation myocardial infarction (STEMI). We aimed to investigate the association between left atrial (LA) mechanical function using speckle tracking imaging and early LVR at follow‐up in STEMI patients.MethodsBaseline 3D thoracic echocardiograms were performed within 48 h following admission and at a median follow‐up of 7 months after STEMI. A > 20% increase in the left ventricular (LV) end‐diastolic volume compared to baseline at follow‐up was defined as LVR. LA global longitudinal strain was evaluated for the reservoir, conduit, and contraction (LASct) phases.ResultsA total of 121 patients without clinical heart failure (HF) were prospectively included, between June 2015 and October 2018 (age 58.3 ± 12.5 years, male 98 (81%)). Baseline and follow‐up LV ejection fraction (LVEF) were 46.8% [41.0, 52.9] and 52.1% [45.8, 57.0] respectively (p < .001). Compared to other patients, those with LVR had significantly lower values of LASct at baseline (−7.4% [−10.1, −6.5] vs. −9.9% [−12.8, −8.1], p < .01), both on univariate and baseline LV volumes‐adjusted analyses. Baseline LA strain for reservoir and conduit phases were not associated with significant LVR at follow‐up. Intra‐ and interobserver analysis showed good reproducibility of LA strain.ConclusionsBaseline LASct may help identifying patients without HF after STEMI who are at higher risk of further early LVR and subsequent HF and who may benefit from more intensive management.