bluuebunny/crossref_metadata_2025_split huggingface dataset:
Customer ecosystems: exploring how ecosystem actors shape customer experience
Authors: Lipkin Michaela , Heinonen Kristina 
Published: March 2022

PurposeThis study aims to characterize how ecosystem actors shape customer experience (CX). The study also proposes implications for managers and research regarding the customer ecosystem, its actors and actor constellations in the context of CXs.Design/methodology/approachA qualitative study is conducted among activity tracker users to identify how actors within their ecosystems shape CXs. Data include 28 in-depth interviews and ten self-reported diaries.FindingsThis study delineates six actor categories in the customer ecosystem shaping CX within and beyond the service. The number of actors and their importance to the focal customer in various actor constellations form individual-, brand- and socially driven ecosystems. These customer ecosystem types show how actors combine to drive CXs.Research limitations/implicationsResearchers should shift their attention to experiences emerging in the customer’s lifeworld. A customer ecosystem highlights the customer-centered actor configuration emergent within the customer’s lifeworld. It is self-constructed based on the customer’s reference point.Practical implicationsManagers should aim to locate, monitor and join the customer’s lifeworld to gain more insight into how CXs emerge in the customer ecosystem based on customer logic.Social implicationsCustomers are not isolated actors simply experiencing service; rather, they construct idiosyncratic actor constellations that include various providers, social groups and peers.Originality/valueThis paper extends the theory on CXs by illustrating how the various actors and actor constellations forming the customer ecosystem shape CXs.
Therapeutic plasma exchange for optic neuritis attacks in patients with neuromyelitis optica spectrum disorders
Authors: Gonzalez Camilo , Vargas Diana , Contreras Kateir , Garcia Paola , Rodriguez Patricia , Zarco Luis , Navas Carlos 
Published: March 2022

AbstractBackgroundOptic neuritis (ON) causes several sequela. Aggressive treatment with plasma exchange (TPE) is an option. This study describes improvement and safety outcomes with TPE.MethodsWe recruited adults with ON in neuromyelitis optica spectrum disorders (NMOSD) patients treated with TPE. The primary outcome was an improvement in the visual acuity scale (VOS). We described the data and used multivariate logistic regression to identify factors associated with response.ResultsEighty‐three patients received 558 TPE sessions. Mean age was 40.9 years (±13.7 years); 73.5% were women, 50.1% were first attack, and 10.7% were bilateral. Median VOS: 5 (range [R], 2–7). Median time between onset and TPE was 8 days (R, 1–32). By Keegan's criteria, 82.4% experience improvement and 78.3% improve in at least 1 point in VOS. Age and pre‐TPE VOS were related to improvement. Low fibrinogen occurs in 26% sessions.ConclusionTPE is effective and safety for ON in NMOSD patients. There is a need for a clinical trial using a therapeutic equivalent.
Genetic polymorphisms within the ETAA1 gene associated with growth traits in Chinese sheep breeds
Authors: Wijayanti Dwi , Erdenee Sarantsetseg , Akhatayeva Zhanerke , Li Haixia , Li Jie , Cai Yong , Jiang Fugui , Xu Hongwei , Lan Xianyong 
Published: March 2022

SummaryEwing tumor‐associated antigen 1 (ETAA1) is an important candidate gene for fat deposition in sheep. This study aimed to investigate the indel variations in the ETAA1 gene and their associations with growth traits in the 1619 sheep. The polymorphism information content of this indel ranged from 0.308 to 0.375, with medium genetic diversity (0.25 ≤ polymorphism information content ≤ 0.5). The correlation analysis showed that an 8‐bp insertion within the ETAA1 gene was significantly associated with growth traits in Luxi Blackhead sheep (LXBH), Lanzhou fat‐tailed sheep, Hu sheep, Tong sheep, and Tan sheep (p < 0.05). Furthermore, the ETAA1 gene was significantly associated with several growth traits (p < 0.01), such as chest width and paunch girth of LXBH, Tong, and Tan rams. It was significantly related to the body morphometric traits of LXBH, Lanzhou fat‐tailed sheep, Hu, Tong, and Tan ewes. In conclusion, the detected 8‐bp indel within the ETAA1 gene was confirmed in sheep, significantly affecting the growth traits, and might be a potential DNA marker for the selection of high‐quality individuals in marker‐assisted selection for sheep breeding.
What do general practitioners want from specialist alcohol and other drug services? A qualitative study of New South Wales metropolitan general practitioners
Authors: Wilson Hester , Schulz Michelle , Rodgers Craig , Lintzeris Nicholas , Hall John J. , Harris‐Roxas Ben 
Published: March 2022

AbstractIntroductionAlcohol and other drug (AOD) use is common in Australia with significant health and community impacts. General practitioners (GP) often see people with AOD use; however, there is little research to understand how specialist AOD services could assist GPs in the management of patients with AOD issues.MethodsThirty‐five GPs working in general practice in a metropolitan area in Sydney in New South Wales, Australia, participated in one of three focus groups. The groups were recorded, transcribed and thematically analysed.ResultsThe five themes raised by participants were: GP personal agency and interest in AOD issues; GP education and training gaps; improving pathways between GP and specialist AOD services; easier access to AOD specialist advice; and improving access to collaborative care for patients with complex AOD presentations. Participants requested education on screening, assessing, managing AOD issues, focused on alcohol, stimulants and high‐risk prescription medicines. They suggested better referral processes, discharge summaries and care planning for complex presentations. Participants wanted easy access to specialist advice and suggested collaborative care assisted by experienced AOD liaison nurses.Discussion and ConclusionsAustralia has several existing programs; online referral pathways and specialist phone advice, that address some of the issues raised. Unfortunately, many participants were not aware of these. GP education must be supported by multiple processes, including durable referral pathways, ready access to local specialist advice, clear communication (including patient attendance and a treatment plan), care planning and written summaries.
Limbic and paralimbic respiratory modulation: From inhibition to enhancement
Authors: Chaitanya Ganne , Hampson Johnson P. , Toth Emilia , Hupp Norma J. , Hampson Jaison S. , Mosher John C. , Pati Sandipan , Lhatoo Samden D. , Lacuey Nuria 
Published: March 2022

AbstractObjectiveIncreased understanding of the role of cortical structures in respiratory control may help the understanding of seizure‐induced respiratory dysfunction that leads to sudden unexpected death in epilepsy (SUDEP). The aim of this study was to characterize respiratory responses to electrical stimulation (ES), including inhibition and enhancement of respiration.MethodsWe prospectively recruited 19 consecutive patients with intractable epilepsy undergoing stereotactic electroencephalography (EEG) evaluation from June 2015 to June 2018. Inclusion criteria were patients ≥18 years in whom ES was indicated for clinical mapping of ictal onset or eloquent cortex as part of the presurgical evaluation. ES was carried out at 50 Hz, 0.2 msec, and 1–10 mA current intensity. Common brain regions sampled across all patients were amygdala (AMY), hippocampus (HG), anterior cingulate gyrus (CING), orbitofrontal cortex (OrbF), temporal neocortex (TNC), temporal pole (TP), and entorhinal cortex (ERC). Seven hundred fifty‐five stimulations were conducted. Quantitative analysis of breathing signal, that is, changes in breathing rate (BR), depth (TV), and minute ventilation (MV), was carried out during ES using the BreathMetrics breathing waveform analysis toolbox. Electrocardiography, arterial oxygen saturation, end‐tidal and transcutaneous carbon dioxide, nasal airflow, and abdominal and thoracic plethysmography were monitored continuously during stimulations.ResultsElectrical stimulation of TP and CING (at lower current strengths <3 mA) increased TV and MV. At >7‐10 mA, CING decreased TV and MV. On the other hand, decreased TV and MV occurred with stimulation of mesial temporal structures such as AMY and HG. Breathing changes were dependent on stimulation intensity. Lateral temporal, entorhinal, and orbitofrontal cortices did not affect breathing either way.SignificanceThese findings suggest that breathing responses other than apnea can be induced by ES. Identification of two regions—the temporal pole and anterior cingulate gyrus—for enhancement of breathing may be important in paving the way to future development of strategies for prevention of SUDEP.
Badass marines: Resistance practices against the introduction of women in the Dutch military
Authors: van Douwen Nina , van den Brink Marieke , Benschop Yvonne 
Published: March 2022

AbstractGender and diversity interventions often do not have the planned effect, at least partly because of resistance. As a result, resistance is predominantly perceived as a negative to overcome. Contributing to theories on resistance to gender change, this paper increases our understanding of resistance practices and explores how these contribute to organizational change. Drawing on a case study in the Dutch military, we present a fine‐grained analysis of the discursive resistance practices to the introduction of women in a previously men‐only military unit. The paper brings together three strands of literature: on gender interventions, on organizational resistance, and on hegemonic military masculinity to unpack the nuances in resistance. We highlight the ambiguities and contradictions in the discursive resistance practices, and explicate how these entail shifts in organizational gender beliefs and the discourse on hegemonic military masculinity. We conclude that instead of trying to avoid resistance, there is a need to better understand what kind of change resistance is already putting into motion.
Significantly enhanced dc electrical resistivity and piezoelectric properties of Tb‐modified CaBi2Nb2O9 ceramics for high‐temperature piezoelectric applications
Authors: Chen Juan‐Nan , Wang Qian , Zhao Xian , Wang Chun‐Ming 
Published: March 2022

AbstractBismuth layer–structured ferroelectric calcium bismuth niobate (CaBi2Nb2O9, CBN) is considered to be one of the most potential high‐temperature piezoelectric materials due to its high Curie temperature Tc of ∼940°C, but the drawbacks of low electrical resistivity at elevated temperature and low piezoelectric performance limit its applications as key electronic components at high temperature (HT). Herein, we report significantly enhanced dc electrical resistivity and piezoelectric properties of CBN ceramics through rare‐earth element Tb ions compositional adjustment. The nominal compositions of Ca1−xTbxBi2Nb2O9 (abbreviated as CBN‐100xTb) have been fabricated by conventional solid‐state reaction method. The composition of CBN‐3Tb exhibits a significantly enhanced dc electrical resistivity of 1.97 × 106 Ω cm at 600°C, which is larger by two orders of magnitude compared with unmodified CBN. The donor substitutions of Tb3+ ions for Ca2+ ions reduce the oxygen vacancy concentrations and increase the band‐gap energy, which is responsible for the enhancement of dc electric resistivity. The temperature‐dependent dc conduction properties reveal that the conduction is dominated by the thermally activated oxygen vacancies in the low‐temperature region (200–350°C) and by the intrinsic conduction in the HT region (350–650°C). The CBN‐3Tb also exhibits enhanced piezoelectric properties with a high piezoelectric coefficient d33 of ∼13.2 pC/N and a high Tc of ∼966°C. Moreover, the CBN‐3Tb exhibits good thermal stabilities of piezoelectric properties, remaining 97% of its room temperature value after annealing at 900°C. These properties demonstrate the great potentials of Tb‐modified CBN for high‐temperature piezoelectric applications.
Management of abiotic stresses by microbiome-based engineering of the rhizosphere
Authors: Tyagi Rashi , Pradhan Salila , Bhattacharjee Annapurna , Dubey Shubham , Sharma Shilpi 
Published: March 2022

AbstractAbiotic stresses detrimentally affect both plant and soil health, threatening food security in an ever-increasing world population. Sustainable agriculture is necessary to augment crop yield with simultaneous management of stresses. Limitations of conventional bioinoculants have shifted the focus to more effective alternatives. With the realization of the potential of rhizospheric microbiome engineering in enhancing plant's fitness under stress, efforts have accelerated in this direction. Though still in its infancy, microbiome-based engineering has gained popularity because of its advantages over the microbe-based approach. This review briefly presents major abiotic stresses afflicting arable land, followed by an introduction to the conventional approach of microbe-based enhancement of plant attributes and stress mitigation with its inherent limitations. It then focuses on the significance of the rhizospheric microbiome and possibilities of harnessing its potential by its strategic engineering for stress management. Further, success stories related to two major approaches of microbiome engineering (generation of synthetic microbial community/consortium, and host-mediated artificial selection) pertaining to stress management have been critically presented. Together with bringing forth the challenges associated with the wide application of rhizospheric microbiome engineering in agriculture, the review proposes the adoption of a combinational scheme for the same, bringing together ecological and reductionist approaches for improvised sustainable agricultural practices.
Changes in community and hospital‐based health care use during the COVID‐19 pandemic for adults with and without intellectual and developmental disabilities
Authors: Durbin A. , Balogh R. , Lin E. , Palma L. , Plumptre L. , Lunsky Y. 
Published: March 2022

AbstractBackgroundDue to the functional, cognitive and communication impairments associated with intellectual and/or developmental disabilities (IDD), adaptations to service delivery during the COVID‐19 pandemic may impact people with IDD differently than others. For community and hospital‐based services, this study describes the proportion of adults with and without IDD who used health care in the year pre‐COVID‐19 and the first year of the pandemic.MethodsThis retrospective cohort study used linked health administrative databases to identify adults aged 18–105 years with and without IDD using unique encoded identifiers. Counts and proportions of adults who used health care services were reported for the pre‐COVID‐19 year (16 March 2019 to 14 March 2020) and the first COVID‐19 year (15 March 2020 to 15 March 2021).ResultsAcross services, the proportion of adults who used services was lower during the first COVID‐19 year compared with the year prior, except for virtual physician visits that increased markedly for people with and without IDD. While the proportion of adults who used services was higher for those with IDD compared with those without IDD for both years, differences were greatest for mental health emergency visits and hospitalisations; adults with IDD were 6.3 to 10.9 times more likely to use these services than others with no IDD during the pandemic.ConclusionsDuring the first COVID‐19 year in Ontario, Canada, service use decreased for all service types, except for virtual physician visits. In both years, adults with IDD remained more likely to use services than other adults, with the largest differences in use of mental health hospitalisations and mental health emergency department visits.
Peripheral and central pathophysiological changes in a new rat model of acid reflux combined with mental stress
Authors: Xu Ting‐Ting , Li Li , Geng Lin , Zhou Bing‐Duo , Zhu Sheng‐Liang 
Published: March 2022

AbstractBackgroundMental stress is an important risk factor for gastroesophageal reflux disease (GERD), which interacts with acid reflux and affects the efficacy of single acid suppression treatment. However, the specific mechanism remains elusive, and there is a lack of available models for further support.MethodsThis study established a new compound model combining acid reflux and chronic unpredictable mild stress (CUMS) to observe potential peripheral and central pathophysiological changes.Key ResultsRats in the compound model suffered from significant weight loss and manifested depression‐like behaviours. In addition, the acid reflux was not aggravated despite the presence of mental stress, along with dilated intercellular space (DIS), increased expression of desmoglein‐1 (DSG1) mRNA, and injury of the lower oesophageal mucosa. The balance between pro‐inflammatory and anti‐inflammatory factors was disrupted. In the hypothalamus of rats in the compound model, the expression of corticosterone‐releasing factor (CRF) and its receptors, protein kinase A (PKA), and γ‐aminobutyric acid (GABA) receptors were decreased. This might be related to the “escape” of stress, which weakened the suppressive effect on excitatory transmission to cope with the damage of pressure to the body.Conclusions & InferencesMental stress and acid reflux affect GERD through peripheral and central aspects, which can result in the poor efficacy of acid inhibitors. This may provide a new direction for the treatment of GERD.
Unique left pulmonary vein isolation in straight common trunk based on longitudinal conduction of left lateral ridge
Authors: Fukuda Koji , Takada Tsuyoshi , Satake Hiroyuki , Aizawa Kentaro , Miki Keita , Shimojyo Takuya , Sato Koichi , Ikeda Shohei , Takeda Morihiko , Shiba Nobuyuki 
Published: March 2022

AbstractBackgroundA left common pulmonary vein (LCPV) is the most common anatomical variation in the pulmonary vein (PV) and often influences strategies of PV isolation for atrial fibrillation (AF). Our objective was to elucidate the electrical properties of the specific shape of LCPV and to apply it to an ablation procedure.Methods and resultsWe investigated consecutive 12 out of 204 paroxysmal AF patients who had the shape of a straight common trunk in LCPV defined by the formation of a single conduit with parallel cranial and caudal walls after the coalescence of superior and inferior PVs on the distal side. The distance between the top of the bifurcation of LPVs and the level coinciding with the middle of the anterior wall of LCPV (left lateral ridge: LLR) was more than 10 mm in all the patients. The activation pattern of the LLR showed longitudinal conduction without outside connections. All the LCPV except one were successfully isolated without ablating the LLR (C‐shape ablation). Only one patient had AF recurrence during the follow‐up period.ConclusionThe LLR in LCPV with a straight common trunk has longitudinal conduction without outside connections, which permits the isolation of LCPV without ablating LLR.
Cauda equina syndrome after unilateral medial branch blocks of the lower lumbar zygapophyseal joints
Authors: Zaghdoudi Zied , Eldabe Sam , Copley Sue , Abbes Haythem , Temperli Philippe , Buchser Eric 
Published: March 2022

AbstractMedial branch blockade of the lumbar facet joints is widely performed and generally accepted as a safe intervention. We present a case of neurological damage following a medial branch blockade with local anesthetic and steroid. A patient suffering from chronic low back pain radiating to the buttocks and thighs underwent nine medial branch blockades over a few years. Three months after successful back surgery to remove a herniated L2–3 disk, the pain recurred, and left L3–4, L4–5, and L5–S1 medial branch blocks were performed under fluoroscopy. Immediately following the procedure, the patient developed paraparesis in both legs, loss of pinprick but preserved fine touch sensation, proprioception, and sphincter sensory and motor function. MRI showed ischemic lesions of the cauda equina. Direct needle trauma was discounted as a cause, due to the bilateral neurological deficit, plus the lack of pain during the procedure. Particulate steroid preparations can form aggregates, which may embolize and block small terminal arteries, causing neurological damage. Although the patient received nine sets of injections uneventfully during the previous 36 months, this procedure took place 3 months following spinal surgery. This rare, but catastrophic case of cauda equina syndrome occurred following L3–4, L4–5, and L5–S1 medial branch blockades 3 months after spinal surgery, which is believed to be caused by accidental intra‐arterial injection of particulate methylprednisolone, with consequent aggregates causing blockage and ensuing ischemia. Therefore we suggest particulate steroid preparations should not be used in axial spinal injection.
Tax revenue effort and aid in fragile states: The case of Comoros
Authors: Diaz‐Sanchez Jose L. , Tagem Abrams M. E. , Mota Joana 
Published: March 2022

AbstractThis paper assesses the impact of aid on tax revenue effort in the context of a fragile state, focusing on Comoros. The paper estimates a fiscal response model within a cointegrated vector autoregressive framework with annual data for Comoros's post‐independence period (1984–2017). Results suggest that grants and tax revenue had a significant negative relationship in the long run that remained stable throughout the sample period. Grants are a politically less costly source of finance, reducing the urgency of fragile states' fiscal planners to expend their reduced political capital and administrative capacity on tax collection reforms. This effect may be amplified by the large one‐off budget support grants received from bilateral partners, which often have stopped tax reform initiatives. From the Comorian government's perspective, being aware of this negative relationship is an important step to ensure that long‐term priorities in tax capacity building are not undermined by short‐term objectives in guaranteeing political stability. Furthermore, multilateral official development partners could attempt to compensate for the negative effect of unconditional aid by engaging additional resources for tax capacity building projects and budget support programmes that include sound tax‐related reforms.