bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identification of thioredoxin domain containing family members' expression pattern and prognostic value in diffuse gliomas via in silico analysis
Authors: Kocatürk Begüm 
Published: September 2022

AbstractBackgroundGliomas are the most prevalent primary tumors of the central nervous system. Their aggressive nature and the obstacles arising during therapy highlights the importance of finding new prognostic markers and therapy targets for gliomas. TXNDC genes are members of the thioredoxin superfamily and were shown to play a role in redox homeostasis, protein folding, electron transfer and also acting as cellular adapters. The well known contribution of these processes in cancer progression prompted us to investigate if TXNDC family members may also play a role in carcinogenesis, in particular diffuse gliomas.MethodsThe present study used in silico analysis tools GEPIA, UCSC Xena, Gliovis, cBioPortal, and Ivy GAP to evaluate the expression pattern, prognostic value and clinical significance of TXNDC family members in diffuse gliomas.ResultsOur analysis showed that TXNDC family members' expression pattern differ between tumors and healthy tissues and among tumors with different grades. The detailed analysis of TXNDC5 in glioma pathogenesis revealed that TXNDC5 expression is associated with more aggressive clinical and molecular features and poor therapy success both in LGG and GBM samples. Kaplan–Meier survival curves represented a worse prognosis for patients with leveated TXNDC5 levels in LGG and all grade glioma patients. The levels of TXNDC5 was shown to be possibly regulated by hypoxia‐ER stress axis and a potential mechanism for TXNDC5‐driven glioma progression was found to be extracellular matrix (ECM) production which is known to promote tumor aggressiveness.ConclusionsOur results uncovered the previously unknown role of TXNDC family members in glioma pathogenesis and showed that TXNDC5 levels could serve as a predictor of clinical outcome and therapy success and may very well be used for targeted therapy.
Clinical care in hepatocellular carcinoma: A mixed methods assessment of experiences and challenges of oncology professionals
Authors: Jacobs Ginny , Boyle Deborah A. , El‐Serag Hashem B. , Lewandowski Robert J. , Stein Stacey M. , Lazure Patrice , McFadden Pam 
Published: September 2022

AbstractIntroductionHealthcare providers (HCPs) may face numerous dilemmas in optimally screening, diagnosing, and treating patients with, and/or at risk for, hepatocellular carcinoma (HCC). This study aimed to achieve a greater understanding of the challenges in HCC care which in turn could delineate HCP educational opportunities within this oncologic sub‐specialty.MethodsA mixed‐methods approach was used to identify practice gaps and clinical barriers experienced by US‐based medical oncologists, hepatologists, oncology physician assistants, oncology nurse practitioners, and interventional radiologists involved in HCC care. The qualitative (semi‐structured interview) and quantitative (survey) data collection approaches were deployed sequentially with findings subsequently triangulated.ResultsA total of 214 HCPs participated in this study. Analysis revealed challenges related to screening and diagnosing HCC, specifically in applying appropriate screening guidelines, and the optimal use and decisions related to diagnostic imaging and biopsy. Issues related to treatment selection included the application of existing HCC guidelines in treatment decision‐making, weighing risk/benefit ratios of various antineoplastics regimens (i.e., tyrosine kinase inhibitors‐TKIs, immunotherapy agents, chemotherapy), sequencing therapies, potential toxicity management, and optimally educating patients about their HCC.ConclusionThese findings highlight the educational needs of those involved in HCC care and provide a starting point for clinicians to both reflect on their practice and identify opportunities to enhance communication within the HCC team and between provider and patient. There is an opportunity to optimize continuing professional development interventions that address the identified gaps in clinical practice specifically related to teamwork and interdisciplinary communication.
Femoral metastasis in previously treated bladder cancer patient: A case report
Authors: Jouma Alhejazi Tala , Bdeiwi Hassan , Sukkari Mohamad W. , Ibrahim Mohamad , Sukari Ammar , Alloush Hani 
Published: September 2022

AbstractAlthough treated appropriately, bladder cancer can recur and metastasize. We are reporting the case of a patient with a well‐cured bladder cancer who presented after 14 months with femoral pain which turned out to be a bony metastasis. The patient underwent surgical excision followed by chemotherapy.
FeSe/FeSe2 Heterostructure as a Low‐Cost and High‐Performance Electrocatalyst for Oxygen Evolution Reaction
Authors: Cheng Zhaoyang , Gao Mengyou , Sun Lei , Zheng Dehua , Xu Huizhong , Kong Linghui , Gao Chang , Yu Haizhou , Lin Jianjian 
Published: September 2022

AbstractA key consensus of implementing large‐scale water splitting is developing highly efficient, durable, and earth‐abundant electrocatalysts for oxygen evolution reaction (OER). In recent years, the Fe‐based materials used in OER have attracted researchers’ great attention around the globe, and Fe has been identified as the OER active sites. In this study, we firstly synthesized the coral‐like FeSe/FeSe2 heterostructure catalyst via a one‐pot solvothermal method. We demonstrated that different components of FeSe/FeSe2 heterostructure can facilitate the electron transfer process of the system, where a high Fe charge state promotes OER performance, rendering the coral‐like FeSe/FeSe2 heterostructure to be more promising Fe‐based electrocatalyst for oxygen evolution reaction in alkaline. As expected, the as‐prepared FeSe/FeSe2 heterostructure with highly charged iron and negatively charged selenium species exhibited better OER performance and needed only an overpotential of 309 mV to achieve an anodic current density of 10 mA cm−2. In addition, the catalyst had quick kinetics and good durability in alkaline medium. The present study would open up a potential avenue for the development of highly active non‐noble‐metal electrocatalysts.
Factors related to mouth breathing syndrome in preschool children and the effects of incompetent lip seal: An exploratory study
Authors: Inada Emi , Saitoh Issei , Kaihara Yasutaka , Murakami Daisuke , Nogami Yukiko , Kiyokawa Yuki , Tanaka Reira , Sakata Kensuke , Yamasaki Youichi 
Published: September 2022

AbstractObjectivesA set of orofacial signs and symptoms completely or partially present in individuals who replace the correct pattern of nasal breathing with an oral or mixed pattern is defined as mouth breathing syndrome (MBS). In a previous report, it was clarified that an incompetent lip seal (ILS) affected the occurrence of MBS among primary school children. However, the factors related to MBS and the effect of ILS in preschool children remain unclear. The purpose of this study was to clarify the factors relevant to MBS in preschool children and investigate the relationship of ILS to MBS.Material and MethodsWe surveyed 285 preschool children between 3 and 5 years of age. Their guardians completed the questionnaire, which consisted of 44 questions regarding the children's daily health conditions and lifestyle habits. To classify the closely related questions into their respective factors and to examine the strength of the correlation between the newly revealed factors, an exploratory factor analysis with promax rotation was performed.ResultsThe factor analysis identified nine items representing four factors. Factors 1–4 were defined as “diseases of the nose,” “ILS,” “problem with swallowing and chewing,” and “eating and drinking habits,” respectively. Factor 2 most strongly correlated with Factor 1, and both Factors showed a relatively strong correlation with Factor 3.ConclusionsThe initial stage of MBS may be present in preschool children. ILS and diseases of the nose can cause poor development of oral functions, such as breathing and eating.
A review on invasive false indigo bush (Amorpha fruticosaL.): Nuisance plant with multiple benefits
Authors: Grabić Jasna , Ljevnaić‐Mašić Branka , Zhan Ai , Benka Pavel , Heilmeier Hermann 
Published: September 2022

AbstractIncreased mobility of people around the globe has facilitated transferring species to new environments, where some have found suitable conditions and even become invasive. False indigo‐bush (Amorpha fruticosaL.) is a plant native to North America but has intentionally or unintentionally spread over the Northern Hemisphere, where it often becomes invasive. The plant is especially easily dispersed within the watersheds of large rivers, where seasonal flooding is regular. Seeds and other propagules are buoyant, and when the water recedes, new plants emerge, forming dense thickets where only a few other species can co‐exist. In order to sustain native biodiversity, spread control is needed. However, mechanical control and eradication measures currently in use are labor demanding and costly, while application of herbicides is limited. On the other hand, the plant possesses a number of beneficial properties, such as phytochemical applications (medical and insecticidal effects), biocoenotic uses (honey plant, ornamental features), and ecosystem services (soil stabilization, provision of food for animals, and fiber and biomass for industry, e.g., nanocellulose). For the reasons above mentioned, the plant is considered quite controversial, and the paper discusses both aspects: potential detrimental effects when introduced to new habitats and its beneficial uses for human society. In addition, the paper presents alternative measures of spreading control (e.g., grazing) and argues that exploiting it for beneficial purposes might help spread control, thus covering the expenses of controlling its distribution.
Dietary Antarctic Krill Oil Enhances the Oral Bioavailability of Nobiletin but Has No Ideal Synergistic Effect on Improving Memory and Cognition Ability in Aβ1–42 Induced Rats
Authors: Kong Jing‐Ya , Wang Cheng‐Cheng , Duan Xue‐Feng , Shi Hao‐Hao , Xue Chang‐Hu , Wei Zi‐Hao , Huang Qing‐Rong , Zhang Tian‐Tian , Wang Yu‐Ming 
Published: September 2022

AbstractNobiletin (Nob) is reported to exhibit neuroprotective properties, which is limited by its low oral bioavailability. Antarctic krill oil (AKO) is abundant in n‐3 polyunsaturated fatty acids in the form of phospholipids, which exhibit an amphiphilic property. It is unclear whether AKO can enhance the bioavailability of nobiletin to facilitate the combined effect on neuroprotection. In the present study, the absorption of Nob carried by AKO is significantly enhanced in contrast to that suspended in corn oil. Moreover, Aβ1–42 injected rats are utilized to clarify the effect of the combination of Nob and AKO on improving the memory and learning ability. Results present that the combination of AKO and Nob significantly reverses the cognitive and learning defects induced by Aβ1–42 injection, but does not have ideal synergistic effect compared to AKO or Nob alone treated groups. Further molecular experiments imply that the neuroprotective effect may be attributed to the reduction of oxidative stress, the inhibition of apoptosis and tau phosphorylation, as well as the improvement of the neurotrophic activity. This study provides scientific insights and theoretical guidance for the nutritional interventions of the combined development of nobiletin and AKO to prevent neuropsychiatric disorders.
Particle saltation trajectories in supercritical open channel flows: Roughness effect
Authors: Demiral Dila , Albayrak Ismail , Turowski Jens M. , Boes Robert M. 
Published: September 2022

AbstractBed load sediment transport governed by particle saltation in supercritical open channel flows causes bedrock incision in high‐gradient mountain streams and hydro‐abrasion at hydraulic structures. Hence, a better understanding of turbulent flow characteristics and particle dynamics is of prime importance for the prediction of river and landscape evolution, and for a sustainable design of hydraulic structures. To this end, we experimentally investigated single‐particle dynamics in supercritical open channel flows over fixed planar and abraded beds covering smooth, transitionally rough, and hydraulically rough regimes. The experiments were performed at the Laboratory of Hydraulics, Hydrology and Glaciology (VAW) of ETH Zürich in a wide range of hydraulic conditions with various channel width‐to‐depth aspect ratios (b/ho) and Froude numbers (F). We investigated the motions of five particle groups differing in shape, hardness, and diameter. By means of a high‐speed camera, the particle velocities and trajectory parameters—such as hop height and hop length—were determined using particle tracking velocimetry. The results reveal that at least 120 individual particles should be used in the tests to determine sound statistics of particle trajectories. In the present test conditions, the particles are dominantly transported in saltation. The effects of particle properties such as shape and diameter on the particle trajectories are negligible, while the rolling probability of the particles for a given flow condition increases with increasing diameter. Bed roughness was found to be the key parameter having a significant effect on the saltation trajectories and horizontal energy transfer. Hop height, hop length, and particle velocities, as well as horizontal energy transfer, increase with increasing bed roughness. Based on the saltation trajectory data, non‐dimensional equations are developed for each hydraulic regime and used to enhance the saltation–abrasion model of Sklar and Dietrich. The present findings contribute to a better understanding of particle motion characteristics under different hydraulic and roughness conditions, and their effect on the mechanics and prediction of bedrock incision and hydro‐abrasion in three‐dimensional supercritical open channel flows occurring in steeply sloped rivers and at hydraulic structures.
Performance evaluation of hybrid transform for universal filtered multi‐carrier system
Authors: Chintala Vijaya Durga , Suddapalli Subba Rao , Sundru Anuradha 
Published: September 2022

AbstractHigh peak to average power ratio (PAPR) is viewed as a serious limitation of all multi‐carrier systems. In this article, a companding transform with clipping technique is proposed for universal filtered multi‐carrier (UFMC) system. The proposed companding transform successfully reduces the PAPR by expanding the small amplitude signals and compressing the peak amplitude signals. Moreover, the combination of companding and clipping further reduces the PAPR. Besides, the proposed scheme provides more flexibility by properly selecting companding parameters and clipping ratio (CR). Additionally, this article presents the performance evaluation of various nonlinear companding transforms (NCTs) of the UFMC system in terms of PAPR reduction, bit‐error‐rate, and reduced out‐of‐band emissions. Simulation results confirm that the proposed hybrid transform provides superior system performance when compared to other NCTs. The proposed hybrid transform with CR of 1.4 provides superior PAPR diminution of 8.5 dB and net gain of 8.9 dB when compared to other schemes. Finally, the proposed hybrid transform is validated by using wireless‐open access‐research platform over real time channel.
Assessment of nutrient adequacy and associated factors among lactating women of rural Bangladesh using observed intake: Findings from Bangladesh Integrated Household Survey 2018–2019
Authors: Islam Saiful , Jubayer Ahmed , Nayan Md. Moniruzzaman , Islam Md. Hafizul , Nowar Abira 
Published: September 2022

AbstractLactating women of low‐ and middle‐income countries are prone to develop deficiencies in essential nutrients due to various demographic and socioeconomic components. This study aimed to estimate the adequacy of dietary intake and the determinants of diet quality of lactating women in rural Bangladesh. One‐day dietary recall (24‐Hour recall) data of 973 lactating women were obtained from the Bangladesh Integrated Household Survey (BIHS) 2018–2019. Nutrient adequacy was determined using the Estimated Average Requirement (EAR) cut‐point approach. The molar ratios of phytate to zinc, calcium, and iron were calculated. Mean Adequacy Ratio (MAR) was calculated to measure diet quality, and multiple linear regression analysis was performed to assess the sociodemographic determinants of MAR. While the intakes of protein and carbohydrate were equal to/above the Acceptable Macronutrient Distribution Range (AMDR) among most of the subjects, intakes of total energy and fat were below the reference intakes for 74.4% and 98.3%, respectively. Nutrient adequacy remained unmet for riboflavin, calcium, vitamin A, and folate among most (87.2%–97.6%) of the study population, and the mean (SD) MAR was 0.72 (0.12). Cereals were the major contributor of energy and B vitamins, while protein and iron mainly came from plant‐based sources. The molar ratio of phytate to iron was greater than the critical limit among most respondents. Maternal Body Mass Index (BMI) (beta = 0.003, p = .014) and education level (beta = 0.017, p = .038) were associated with their diet quality. The diet of most lactating women in rural Bangladesh indicates the inadequacy of several micronutrients. This can lead to a worsening of the double burden of malnutrition in women. Lactating women should be given special consideration when designing food and nutrition programs for reproductive women in rural Bangladesh.
Chemical composition of kabuli and desi chickpea (Cicer arietinum L.) cultivars grown in Xinjiang, China
Authors: Xiao Shiqi , Li Zhenglei , Zhou Keqiang , Fu Yinghua 
Published: September 2022

AbstractChickpeas are a very important legume crop and have abundant protein, carbohydrate, lipid, fiber, isoflavone, and mineral contents. The chemical compositions of the four chickpea species (Muying‐1, Keying‐1, Desi‐1, Desi‐2) from Xinjiang, China, were analyzed, and 46 different flavonoids in Muying‐1 were detected. The moisture content ranged from 7.64 ± 0.01 to 7.89 ± 0.02 g/100 g, the content of starch in the kabuli chickpeas was greater than that in the desi chickpeas, the total ash content ranged from 2.59 ± 0.05 to 2.69 ± 0.03 g/100 g and the vitamin B1 content of the chickpeas ranged from 0.31 to 0.36 mg/100 g. The lipid content ranged from 6.35 to 9.35 g/100 g and the major fatty acids of chickpeas were linoleic, oleic, and palmitic acids. Both kabuli and desi chickpeas have a high content of unsaturated fatty acids (USFAs), Muying‐1 and Desi‐1 contained the highest level of linoleic acid, and Keying‐1 had the highest oleic acid content. The protein level ranged from 19.79 ± 2.89 to 23.38 ± 0.30 g/100 g, and the main amino acids were aspartic acid, glutamic acid, and arginine acid. The four chickpea species had significant amounts of essential amino acids (EAAs). Forty‐six varieties of flavonoids in Muying‐1 were determined by ultra high‐performance liquid chromatography coupled with triple quadrupole mass spectrometry (UPLC‐QqQ‐MS) analysis, and there were higher levels of conjugate flavonoids (55.95%) than free flavonoids (44.05%). Isoflavones were the most abundant flavonoids in Muying‐1, and among the isoflavones, daidzin had the highest content, followed by biochanin A and genistin. Muying‐1 was rich in daidzin, biochanin A, genistin, troxerutin, isorhamnetin, astilbin, L‐epicatechin, astragalin, acacetin, hyperoside, and myricitrin. Information provided in the study will be helpful to further understand the chemical composition of chickpeas and be beneficial to the development of chickpeas.
The impact of wildfire smoke and temperature on traumatic worker injury claims, Oregon 2009–2018
Authors: Evoy Richard , Hystad Perry , Bae Harold , Kincl Laurel 
Published: September 2022

AbstractBackground and AimsAs average temperatures rise and wildfire events increase in the United States, outdoor workers may be at an increased risk of injury. Recent research suggests that heat exposure increases outdoor workers' risk of traumatic injuries, but co‐exposures of heat and wildfire smoke have not been evaluated.MethodsOregon workers' compensation data from 2009 to 2018 were linked to satellite data by the date of injury to determine if acute heat (maximum Heat Index) and wildfire smoke (presence/absence) were associated with a traumatic injury. North American Industry Classification System (NAICS) codes were utilized to identify accepted, disabling injury claims from construction (NAICS 23) and agriculture, forestry, fishing, and hunting (NAICS 11). Claims from April to October were analyzed using negative binomial models to calculate incident rate ratios (IRR) by heat and wildfire exposure for All workers and specifically for Agricultural (Ag)/Construction workers.ResultsDuring the study period, 91,895 accepted, traumatic injury claims were analyzed. All workers had an injury IRR of 1.04 (95% confidence interval [CI]: 1.02–1.06) while Ag/Construction workers had an IRR of 1.11 (95% CI: 1.06–1.16) when wildfire smoke was present. When the maximum Heat Index was 75°F or greater, the IRR significantly increased as temperatures increased. When the maximum Heat Index was above 80–84°F, All workers had an IRR of 1.04 (95% CI: 1.01–1.06) while Ag/construction workers had an IRR of 1.14 (95% CI: 1.08–1.21) with risk increasing with increased temperatures. In joint models, heat remained associated with injury rates, but not wildfire smoke. No multiplicative interactions between exposures were observed.ConclusionIncreasing temperature was associated with increased rates of traumatic injury claims in Oregon that were more pronounced in Ag/Construction workers. Future work should focus on further understanding these associations and effective injury prevention strategies.
Neutrophil‐to‐lymphocyte ratio as a predictor of clinical outcomes in critically ill COVID‐19 patients: A retrospective observational study
Authors: Ali Husain S. , Ananthegowda Dore C. , Ebrahim Ebrahim M. A. , Kannappilly Nevin , Al Wraidat Mohammad , Mohamed Ahmed S. , Khatib Mohamad Y. 
Published: September 2022

AbstractBackgroundTimely identification of patients at risk of worse clinical outcomes is vital in managing coronavirus disease 2019 (COVID‐19). The neutrophil‐to‐lymphocyte ratio (NLR) calculated from complete blood count can predict the degree of systemic inflammation and guide therapy accordingly. Hence, we did a study to investigate the role of NLR value on intensive care unit (ICU) admission in predicting clinical outcomes of critically ill COVID‐19 patients.MethodsWe conducted a retrospective analysis of electronic health records of COVID‐19 patients admitted to ICUs at Hazm Mebaireek General Hospital, Qatar, from March 7, 2020 to July 18, 2020. Patients with an NLR equal to or higher than the cut‐off value derived from the receiver operating characteristic curve were compared to those with an NLR value below the cut‐off. The primary outcome studied was all‐cause ICU mortality. The secondary outcomes evaluated were the requirement of mechanical ventilation and ICU length of stay (LOS).ResultsFive hundred and nineteen patients were admitted to ICUs with severe COVID‐19 infection during the study period. Overall, ICU mortality in the study population was 14.6% (76/519). NLR on ICU admission of ≥6.55 was obtained using Youden's index to predict ICU mortality, with a sensitivity of 81% and specificity of 41%. Mortality was significantly higher in patients with age ≥60 years (p < 0.001), chronic kidney disease (p = 0.03), malignancy (p < 0.002), and NLR ≥ 6.55 (p < 0.003). There was also a significant association between the requirement of mechanical ventilation (34.7% vs. 51.8%, p < 0.001) and increased ICU LOS (8 vs. 10 days, p < 0.01) in patients with ICU admission NLR ≥ 6.55.ConclusionHigher NLR values on ICU admission are associated with worse clinical outcomes in critically ill COVID‐19 patients.