bluuebunny/crossref_metadata_2025_split huggingface dataset:
Long-Term Health-Related Quality of Life of Autologous Hematopoietic Cell Transplantation Patients and Nontransplant Patients With Aggressive Lymphoma: A Prospective Cohort Analysis
Authors: Strouse Christopher S. , Larson Melissa C. , Ehlers Shawna L. , Yost Kathleen J. , Maurer Matthew J. , Ansell Stephen M. , Inwards David J. , Johnston Patrick B. , Micallef Ivana N. , Link Brian K. , Farooq Umar , Cerhan James R. , Thompson Carrie A. 
Published: May 2022

PURPOSE: This study assessed the long-term quality of life (QOL) of patients with aggressive lymphoma subtypes treated with autologous hematopoietic cell transplant (autoHCT) compared with those without history of transplant. METHODS: Patient-reported QOL measures were prospectively gathered from patients enrolled in the Iowa/Mayo Specialized Program of Research Excellence Molecular Epidemiology Resource cohort with aggressive lymphoma subtypes. QOL was measured using the Functional Assessment of Cancer Therapy-General (FACT-G), Functional Assessment of Chronic Illness Therapy–Fatigue Scale, State-Trait Anxiety Inventory (STAI), and Profile of Mood States instruments and with a numeric rating scale for overall QOL and spiritual QOL. The autoHCT group and no HCT groups were compared at 3 years (FU3) and 6 years (FU6) after lymphoma diagnosis. RESULTS: In total, 980 patients with lymphoma (106 autoHCT and 874 no HCT) diagnosed between 2002 and 2013 were included for analysis. The mean FACT-G total score was similar in the autoHCT and no HCT groups at FU3 (89.9 v 90.1, P = .64) and also at FU6 (91.5 v 89.6, P = .44). No differences between the autoHCT and no HCT groups were identified in the FACT subscales. The STAI identified lower anxiety in the autoHCT group by mean STAI1 (state) at FU3 (30.1 v 33.4, P < .01) and by mean STAI2 (trait) at FU6 (30.1 v 33.5, P = .02). No other clinically meaningful differences were identified between the two groups using the other QOL instruments. CONCLUSION: Patients remaining in remission at 3 and 6 years after diagnosis had a high level of QOL with no significant differences associated with history of treatment with autoHCT.
Single-cell RNA-sequencing of mammalian brain development: insights and future directions
Authors: Vinsland Elin , Linnarsson Sten 
Published: May 2022

ABSTRACT
Understanding human brain development is of fundamental interest but is also very challenging. Single-cell RNA-sequencing studies in mammals have revealed that brain development is a highly dynamic process with tremendous, previously concealed, cellular heterogeneity. This Spotlight discusses key insights from these studies and their implications for experimental models. We survey published single-cell RNA-sequencing studies of mouse and human brain development, organized by anatomical regions and developmental time points. We highlight remaining gaps in the field, predominantly concerning human brain development. We propose future directions to fill the remaining gaps, and necessary complementary techniques to create an atlas integrated in space and time of human brain development.
A unique form of collective epithelial migration is crucial for tissue fusion in the secondary palate and can overcome loss of epithelial apoptosis
Authors: Teng Teng , Teng Camilla S. , Kaartinen Vesa , Bush Jeffrey O. 
Published: May 2022

ABSTRACT
Tissue fusion frequently requires the removal of an epithelium that intervenes distinct primordia to form one continuous structure. In the mammalian secondary palate, a midline epithelial seam (MES) forms between two palatal shelves and must be removed to allow mesenchymal confluence. Abundant apoptosis and cell extrusion support their importance in MES removal. However, genetically disrupting the intrinsic apoptotic regulators BAX and BAK within the MES results in complete loss of cell death and cell extrusion, but successful removal of the MES. Novel static- and live-imaging approaches reveal that the MES is removed through streaming migration of epithelial trails and islands to reach the oral and nasal epithelial surfaces. Epithelial trail cells that express the basal epithelial marker ΔNp63 begin to express periderm markers, suggesting that migration is concomitant with differentiation. Live imaging reveals anisotropic actomyosin contractility within epithelial trails, and genetic ablation of actomyosin contractility results in dispersion of epithelial collectives and failure of normal MES migration. These findings demonstrate redundancy between cellular mechanisms of morphogenesis, and reveal a crucial and unique form of collective epithelial migration during tissue fusion.
Accelerating animal energetics: high dive costs in a small seabird disrupt the dynamic body acceleration–energy expenditure relationship
Authors: Ste-Marie Eric , Grémillet David , Fort Jérôme , Patterson Allison , Brisson-Curadeau Émile , Clairbaux Manon , Perret Samuel , Speakman John R. , Elliott Kyle H. 
Published: May 2022

ABSTRACT
Accelerometry has been widely used to estimate energy expenditure in a broad array of terrestrial and aquatic species. However, a recent reappraisal of the method showed that relationships between dynamic body acceleration (DBA) and energy expenditure weaken as the proportion of non-mechanical costs increases. Aquatic air breathing species often exemplify this pattern, as buoyancy, thermoregulation and other physiological mechanisms disproportionately affect oxygen consumption during dives. Combining biologging with the doubly labelled water method, we simultaneously recorded daily energy expenditure (DEE) and triaxial acceleration in one of the world's smallest wing-propelled breath-hold divers, the dovekie (Alle alle). These data were used to estimate the activity-specific costs of flying and diving and to test whether overall dynamic body acceleration (ODBA) is a reliable predictor of DEE in this abundant seabird. Average DEE for chick-rearing dovekies was 604±119 kJ day−1 across both sampling years. Despite recording lower stroke frequencies for diving than for flying (in line with allometric predictions for auks), dive costs were estimated to surpass flight costs in our sample of birds (flying: 7.24× basal metabolic rate, BMR; diving: 9.37× BMR). As expected, ODBA was not an effective predictor of DEE in this species. However, accelerometer-derived time budgets did accurately estimate DEE in dovekies. This work represents an empirical example of how the apparent energetic costs of buoyancy and thermoregulation limit the effectiveness of ODBA as the sole predictor of overall energy expenditure in small shallow-diving endotherms.
Facile Synthesis of Highly Uniform ZnMn2O4 Hollow Nanospheres with Excellent Lithium Storage Properties
Authors: Qi Shuai , Li Yan , Liu Zhiyuan , Zhang Rui , Wang Qing , Hou Yongzhao , Qiu Yao , Zhang Lijuan , Wen Guangwu , Wang Dong 
Published: May 2022

Abstract
Hollow nano/micron-structured transition metal oxides (TMOs) hold great potential as electrodes for rechargeable batteries, due to abundant electrochemically active sites, shortened ion diffusion length, and robust architecture. Herein, a facile solvothermal approach combined with post annealing is reported for synthesizing highly uniform ZnMn2O4 hollow nanospheres. The one-pot solvothermal reaction is the key step to form a hollow interior. With solvothermal reaction processing, the precursor solid nanospheres are formed firstly, which gradually evolve into core-shelled structures and finally hollow structures via a self-templated process. Then, the ZnMn2O4 nanospheres with well-inherited hollow interior are obtained by the thermal decomposition of precursors. When evaluated as an electrode, the ZnMn2O4 hollow nanospheres show lithium storage properties superior to solid counterparts, in view of high reversible capacity (735.0 mAh g−1 after 200 cycles at 0.1 A g−1), and ultralong cyclic stability (up to 1000 cycles at 1 A g−1). A dominant pseudocapacitive contribution of 60.0% is identified for the ZnMn2O4 hollow electrode, leading to excellent rate performance. This work provides a new path for preparing TMOs with hierarchically hollow structure.
PEMBERDAYAAN MASYARAKAT DALAM AKTIVITAS FISIK DAN KELUARGA SADAR GIZI GUNA MEWUJUDKAN GERAKAN MAYARAKAT HIDUP SEHAT (GERMAS)
Authors: Isni Khoiriyah , Aini Zahrotul , Phamuji Andrei , Nafila Ukhtika Zulfa , Pratiwi Desty , Mala Nunky Eltanin Mala , Ramadhan Alfi Syahri , Vega Ferry Nandito Dela 
Published: May 2022

Di daerah dusun Pelemwulung banyak masyarakat yang belum melakukan aktivitas fisik dan masih banyak masyarakatnya yang belum mengonsumsi suplemen gizi karena masyarakat kurang tahu fungsi dari aktivitas fisik dan mengonsumsi suplemen gizi bagi keluarga.Tujuan kegiatan ini untuk pemberdayaan masyarakat ini adalah untuk menginisiasi dan Â memberdayakan Â masyarakat dalam mewujudkan PHBS dan kadarzi melalui kegiatan aktivitas fisik. Metode yang digunakan dalam pemberdayaan masyarakat ini dengan adanya MMD dan dilanjutkan dengan melakukan intervensi berupa senam pagi. Pada hasil intervensi didapatkan hasil yaitu: masyarakat yang masih belum sadar pentingnya melakukan aktifitas fisik. Hasil yang didapat dari aktivitas fisik bahwa tidak terdapat korelasi atau nilai p-value 0,52 (p > 0,05) yang bermakna antara pengetahuan dan perilaku artinya semakin tinggi pengetahuan maka perilaku dalam melakukan aktifitas fisik rendah. Sedangkan untuk KADARZI bahwa terdapat korelasi dengan nilai p-value 0,032 (p < 0,05) yang bermakna antara pengetahuan dan perilaku tentang KADARZI artinya semakin tinggi pengetahuan tentang KADARZI maka semakin tinggi pula perilaku KADARZI. Kesimpulan kegiatan yang dilakukan di Dusun Pelemwulung yaitu terkait dengan melakukan aktivitas fisik, dengan mengadakan kegiatan senam sehat bagi seluruh masyarakat di Dusun Pelemwulung guna tercapainya penerapan PHBS dan KADARZI dan sarannya yaitu menanamkan tingkat kesadaran dalam melakukan aktifitas fisik dan KADARZI.
Laser stripe segmentation and centerline extraction based on 3D scanning imaging
Authors: Ye Chuan , Feng Wenrong , Wang Qiyan , Wang Chao , Pan Bo , Xie Youchun , Hu Yuanyao , Chen Jian 
Published: May 2022

Ambient noise and illumination inhomogeneity will seriously affect the high-precision measurement of structured light 3D morphology. To overcome the influences of these factors, a new, to the best of our knowledge, sub-pixel extraction method for the center of laser stripes is proposed. First, an automatic segmentation model of structured light stripe based on the UNet deep learning network and level set is constructed. Coarse segmentation of laser stripes using the UNet network can effectively segment more complex scenes and automatically obtain a prior shape information. Then, the prior information is used as a shape constraint for fine segmentation of the level set, and the energy function of the level set is improved. Finally, the stripe normal field is obtained by calculating the stripe gradient vector, and the center of the stripe is extracted by fusing the gray center of gravity method according to the normal direction of the stripe distribution. The experimental results show that the average width error of different rows of point cloud data of workpieces with different widths is less than 0.3 mm, and the average repeatability extraction error is less than 0.2 mm.
Micro-opto-electro-mechanical system based microcantilever sensor for
biosensing applications
Authors: Upadhyaya Anup M. , Sharan Preeta , Srivastava Maneesh C. 
Published: May 2022

The strain sensing action of a photonic integrated microcantilever induced by the binding of biomolecules such as antibodies and antigens is an important factor in biosensing applications. Since sensitivity is the key factor in sensor performance for early detection of any bio analyte, increasing the sensitivity of the photonic integrated microcantilever becomes more critical. This can be achieved by varying the geometry of the microcantilever. Two photonic integrated microcantilever configurations—stepped profile and T-shaped microcantilevers—are considered for pressure sensing, and a comparative analysis between both designs is presented. The sensitivity of the microcantilever is improved for a small magnitude of force such as 0.1 MPa to 0.4 MPa for the T-shaped profile of the microcantilever. The resonant wavelength and wavelength shift between two structures are evaluated for various ranges of applied pressure. Sensitivities of the stepped profile and T-shaped microcantilevers are calculated as 0.58 nm/MPa in the range of 10 MPa to 25 MPa, and 92 nm/MPa in the range of 0.1 MPa to 0.4 MPa, respectively. Simulation results show that the proposed sensing configuration, i.e., T-shaped microcantilever, has high sensitivity and a significant range of wavelength at low-pressure values. This capability of the T-shaped microcantilever enhances feasibility for future fabrication and implementation in different biomedical applications.
Economic burden of dengue fever in China: A retrospective research study
Authors: Xu Meng , Chang Nan , Tu Taotian , Sun Jimin , Jiang Jinyong , Xia Yu , Tang Wenge , Ji Hengqing , Zhao Xiaotao , Zhu Jin , Qi Li , Liu Xiaobo , Liu Qiyong 
Published: May 2022

Background
Dengue fever has been a significant public health challenge in China. This will be particularly important in the context of global warming, frequent international travels, and urbanization with increasing city size and population movement. In order to design relevant prevention and control strategies and allocate health resources reasonably, this study evaluated the economic burden of dengue fever in China in 2019.

Methods
The economic burden of dengue fever patients was calculated from both family and the organisation perspectives. A survey was conducted among 1,027 dengue fever patients in Zhejiang, Chongqing, and Yunnan Provinces. Treatment expenses, lost working days, and insurance reimbursement expenses information were collected to estimate the total economic burden of dengue fever patients in 2019. The expenditures related to dengue fever prevention and control from government, Center for Disease Control and Prevention (CDC), communities and subdistrict offices of 30 counties (or districts) in Zhejiang Province and Chongqing City were also collected.

Results
The direct, indirect and total economic burden for dengue fever patients in 2019 in the three Provinces were about 36,927,380.00 Chinese Yuan (CNY), 10,579,572.00 CNY and 46,805,064.00 CNY, respectively. The costs for prevention and control of dengue fever for the counties (or districts) without cases, counties (or districts) with imported cases, and counties (or districts) with local cases are 205,800.00 CNY, 731,180.00 CNY and 6,934,378.00 CNY, respectively. The total investment of dengue fever prevention and control in the 30 counties in China in 2019 was approximately 3,166,660,240.00 CNY.

Conclusion
The economic burden of dengue fever patients is relatively high, and medical insurance coverage should be increased to lighten patients’ direct medical economic burden. At the same time, the results suggests that China should increase funding for primary health service institutions to prevent dengue fever transmission.
Obstacles to university food pantry use and student-suggested solutions: A qualitative study
Authors: El Zein Aseel , Vilaro Melissa J. , Shelnutt Karla P. , Walsh-Childers Kim , Mathews Anne E. 
Published: May 2022

BackgroundIn the absence of federal programs and policies to alleviate college student food insecurity, the number of food pantries has grown rapidly in the United States. Yet, no studies, to date, have qualitatively examined students’ experiences with this resource.ObjectiveTo explore college students’ perspectives on barriers to using an on-campus food pantry and provide insights into student-suggested solutions.MethodsIn this qualitative study, 41 college students were recruited from a large public university in the southeastern US with a campus food pantry. Students participated in one-on-one, in-person, semi-structured interviews. All interviews were audio-recorded, transcribed verbatim, managed using NVivo 12, and analyzed using inductive, semantic thematic analysis.ResultsMost students were classified as food insecure (n = 33, 82.5%), and two-thirds identified as pantry users (at least once). The students’ reasons for not using the food pantry indicated resistance and access barriers. Students either ‘chose not to use’ the campus food pantry due to (i) stigma and shame, (ii) perceived insufficient need, (iii) and unsuitable food or they experienced ‘barriers’ due to (i) lack of knowledge and (ii) limited food access. The main reason reported by food insecure non-pantry users was feelings of stigma and shame while that of food insecure pantry users was limited food access. Students suggested three solutions to minimize barriers experienced when utilizing the campus food pantry. These included (i) spreading awareness about the pantry through positive marketing messages that de-stigmatize use, (ii) improving accessibility of fresh produce and protein options, and (iii) improving access through satellite locations and online ordering systems.ConclusionThese barriers need to be systematically addressed to normalize food pantry use. Consideration of student recommendations by university program developers and policymakers may be of added value to expand access to food by college students with food insecurity.
Stereotactic body radiotherapy plus transcatheter arterial chemoembolization for inoperable hepatocellular carcinoma patients with portal vein tumour thrombus: A meta-analysis
Authors: Zhang Xiao-fei , Lai Lin , Zhou Hui , Mo Yuan-jun , Lu Xu-quan , Liu Min , Lu Yun-xin , Hou En-cun 
Published: May 2022

Background
The efficacy and safety of stereotactic body radiotherapy (SBRT) plus transcatheter arterial chemoembolization (TACE) versus SBRT or TACE alone(monotherapy) for hepatocellular carcinoma (HCC) patients with portal vein tumour thrombus (PVTT) remains controversial. This meta-analysis was performed to provide more powerful evidence for clinical strategies in inoperable HCC with PVTT.

Methods
We searched the PubMed, EMBASE, Web of Science, Cochrane Library, China Biology Medicine (CBM), China National Knowledge Infrastructure (CNKI), VIP Journal Integration Platform (VIP), and WanFang databases for eligible studies. We pooled the results of 1- and 2-year overall survival rates (OSRs), objective response rates (ORRs), and adverse events (AEs) between the two groups and performed a subgroup meta-analysis for study type, control group, treatment order, and the interval between SBRT and TACE.

Results
Nine studies with 10 cohorts involving 938 patients were included in our meta-analysis. SBRT plus TACE yielded significantly higher 1-year OSR (RR, 1.52[95% CI, 1.33–1.74]), 2-year OSR (RR, 2.00 [95% CI: 1.48–2.70]), ORR (RR = 1.22 [95% CI, 1.08–1.37]), and a lower progression disease (PD) rate (RR = 0.45 [95% CI:0.26–0.79]) than monotherapy. No significant differences were detected in CR, PR, SD, or AEs between the two groups. Subgroup analysis regarding study type, control group, and treatment order indicated that compared with monotherapy, the combination of SBRT with TACE was associated with an increase in 1- and 2-year OSRs but not in ORR. In regard to the interval between SBRT and TACE, subgroup analysis found that the combination therapy for patients with an SBRT-TACE interval <28 days was preferable to monotherapy in the 1- and 2-year OSRs, and ORR. However, for patients with an SBRT-TACE interval ≥28 days, no obvious distinctions were observed in the 1-year OSR, 2-year OSR, or ORR between the two groups.

Conclusion
The combination of SBRT with TACE appears to be better than monotherapy in treating HCC with PVTT and should be recommended for inoperable HCC patients with PVTT.
Protective effect conferred by prior infection and vaccination on COVID-19 in a healthcare worker cohort in South India
Authors: Murugesan Malathi , Mathews Prasad , Paul Hema , Karthik Rajiv , Mammen Joy John , Rupali Priscilla 
Published: May 2022

Background
The emergence of newer variants with the immune escape potential raises concerns about breakthroughs and re-infections resulting in future waves of infection. We examined the protective effect of prior COVID-19 disease and vaccination on infection rates among a cohort of healthcare workers (HCW) in South India during the second wave driven mainly by the delta variant.

Methods and findings
Symptomatic HCWs were routinely tested by RT-PCR as per institutional policy. Vaccination was offered to all HCWs in late January, and the details were documented. We set up a non-concurrent cohort to document infection rates and estimated protective efficacy of prior infection and vaccination between 16th Apr to 31st May 2021, using a Cox proportional hazards model with time-varying covariates adjusting for daily incidence. Between June 2020 and May 2021, 2735 (23.9%) of 11,405 HCWs were infected, with 1412, including 32 re-infections, reported during the second wave. 6863 HCWs received two doses of vaccine and 1905 one dose. The protective efficacy of prior infection against symptomatic infection was 86.0% (95% CI 76.7%–91.6%). Vaccination combined with prior infection provided 91.1% (95% CI 84.1%–94.9%) efficacy. In the absence of prior infection, vaccine efficacy against symptomatic infection during the second wave was 31.8% (95% CI 23.5%– 39.1%).

Conclusions
Prior infection provided substantial protection against symptomatic re-infection and severe disease during a delta variant driven second wave in a cohort of health care workers.
Beyond the World’s End: Arts of Living at the Crossing, T. J. Demos (2020)
Authors: Kispert Matthias 
Published: May 2022

Review of: Beyond the World’s End: Arts of Living at the Crossing, T. J. Demos (2020)
Durham and London: Duke University Press, 272 pp.,
ISBN 978-1-47800-957-3, p/bk, £20.90
In Fading Light: The Films of the Amber Collective, James Leggott (2020)
Authors: Perry Colin 
Published: May 2022

Review of: In Fading Light: The Films of the Amber Collective, James Leggott (2020)
New York and Oxford: Berghahn Books, 268 pp.,
ISBN 978-1-78920-651-7, e-book, £25.00
Diagnóstico del carcinoma medular de tiroides
Authors: Herrero Ruiz Ana , Sánchez Marcos Ana Isabel , Martín Almendra María Angeles , García Duque María , Beaulieu Oriol Louisa Myriam , Mories Álvarez María Teresa 
Published: May 2022

Introducción: El carcinoma medular de tiroides (CMT) es un tumor maligno neuroendocrino poco frecuente derivado de las células parafoliculares o células C del tiroides. En el momento del diagnóstico presentan metástasis ganglionares más del 50% y a distancia el 10%. Su pronóstico depende en gran parte del estadio del tumor, por lo que su diagnóstico temprano es fundamental.
Objetivo: El objetivo de este trabajo es realizar una revisión actualizada sobre el abordaje diagnóstico del CMT.
Síntesis: La ecografía es la principal herramienta en la estratificación del nódulo tiroideo, pero la mayor parte de los estudios se han centrado en el carcinoma papilar de tiroides. En el caso del CMT las características ecográficas sospechosas de malignidad suelen ser menos frecuentes y esto podría conducir a un retraso diagnóstico y terapéutico, por lo que se debe combinar con técnicas diagnósticas adicionales. En estos tumores la sensibilidad del estudio citológico del nódulo mediante punción aspiración con aguja fina generalmente es baja, y en aquellos casos de sospecha de CMT se recomienda realizar inmunohistoquímica para calcitonina y determinar la calcitonina en el aspirado de la punción. La calcitonina plasmática es el marcador más sensible para el diagnóstico de estos pacientes, pero su determinación rutinaria en el estudio del nódulo tiroideo es controvertida. Sus niveles se relacionan con la masa de células C y la presencia de metástasis ganglionares. Si son superiores a 500 pg/ml se recomienda realizar estudio de extensión con pruebas de imagen complementarias por sospecha de enfermedad metastásica. Es importante solicitar estudio genético a todos los pacientes, ya que el 25% son hereditarios formando parte de la neoplasia endocrina múltiple tipo 2 asociada a mutación en el gen RET.