bluuebunny/crossref_metadata_2025_split huggingface dataset:
Face-to-Face Assessment of Basic Life Support Knowledge: A Prospective Study
Authors: Daou Rafi , Abillama Fayez , Tanios Alain , Estephan Michelle , Nakhle Ramzi , Khoury Vanessa , Boulos Rasha 
Published: May 2022

Abstract
Introduction: Basic Life Support (BLS) is the rapid detection of cardiac arrest and the initial adequate response to maintain adequate ventilation and circulation. Multiple studies around the world have shown that when used infrequently, BLS skills will deteriorate within 3 to 6 months after training, even though the theoretical knowledge was retained longer. We aim to identify differences in training and knowledge among different physician populations according to their age, specialty, and area of practice and provide areas of improvements. Methods: A multi-center prospective cross-sectional study was conducted in 14 institutions around all areas of Lebanon from January 2017 to December 2019. A structured questionnaire adapted from pretest questionnaire that has been previously used in similar studies was implemented. Data Analysis was performed using the R software version 3.5.1. We used graphical boxplot representation of the data to demonstrate the distribution of our results. Results: 201 responses from randomly chosen physicians were collected. Out of these 201 physicians, ten physicians answered all questions correctly and twelve others only answered two questions correctly. Only 39.80% (80) of physicians achieved “sufficient knowledge” level. Conclusion: This present study highlights the need for BLS course to be implemented and given to all physicians and the importance of a refreshment course to all physicians.
Treatment of Extramedullary Plasmacytoma of the Rectum with Endoscopic Mucosal Resection: A Case Report and Literature Review
Authors: Fan Ling , Fu Yan , Liu Yi , Huang Hua 
Published: May 2022

Abstract
Background: Extramedullary plasmacytoma (EMP) is an unusual plasma cell disease. The diagnosis of EMP requires biopsy-proven monoclonal plasma cell infiltration of a single lesion, and the exclusion of multiple myeloma, which can be challenging. EMP most commonly occurs in the head and neck, with the gastrointestinal tract rarely involved. The clinical suspicion of gastrointestinal EMP is infrequent owing to its location and nonspecific manifestations. EMP localized in the rectal is extremely rare, Only 13 cases have been reported in the English-language literature as far as we know. We report a case of EMP arising in the rectum, which is fully removed using endoscopic mucosal resection.Case presentation: A 64-year-old woman was referred to our hospital with recurrent diarrhea for longer than half a month. She underwent colonoscopy which revealed a polypoid lesion of rectum, the lesion was fully excised using endoscopic mucosal resection. The pathology specimens showed massive infiltration of tumour plasma cells, and the immunohistochemical staining showed that: CD38 (+), CD79a (+), Mum - 1 (+), IgG (+), kappa (+), whereas the CD20 (-), CD3 (-), CD5 (-), lambda (-). The histopathological examination coupled with immunohistochemistry of the endoscopic biopsy confirmed a primary EMP of rectum after excluding multiple myeloma. She did not receive radiotherapy or chemotherapy after being diagnosed with EMP and experienced no recurrence or progression during the 6-month follow-up period.Conclusions:Rectal EMP is an extremely rare clinical entity, a definitive diagnosis relies on histopathological analysis, which usually obtained following endoscopy with biopsy or surgical resection of the tumor. Although rectal EMP has an indolent course and favorable prognosis, long-term follow-up is recommended due to the possibility of relapse or progression to multiple myeloma. We hope that the endoscopic and histopathological findings and treatment of solitary rectal EMP we present will be valuable for the management of similar manifestations of EMP in other patients.
Evaluation of the metabolomic profile through ¹H-NMR spectroscopy in ewes affected by hyperketonemia
Authors: Lisuzzo Anastasia , Laghi Luca , Fiore Filippo , Harvatine Kevin , Mazzotta Elisa , Faillace Vanessa , Spissu Nicoletta , Zhu Chenglin , Moscati Livia , Fiore Enrico 
Published: May 2022

Abstract
Ketosis is one of the most important health problems in dairy sheep. The aim of this study was to evaluate the metabolic alterations in hyperketonemic ewes. Forty-six adult Sardinian ewes were enrolled between 7 ± 3 days after partum. Blood samples were collected in Venosafe tubes containing clot activator from jugular vein after clinical examination. The β-hydroxybutyrate (BHB) was evaluated on serum and used to divide ewes into two groups: Group H (serum BHB < 0.86 mmol/L) and Group K (serum BHB ≥ 0.86 mmol/L). Animal data and biochemical parameters of groups were examined with one-way ANOVA, whereas the metabolite significant differences were examined by t-test. A robust principal component analysis model and a heatmap were used to highlight possible common trends among metabolites. Over-representation analysis was performed to investigate metabolic pathways potentially altered in connection with the studied BHB alterations. The metabolomic analysis identified 54 metabolites and 14 were significant. These metabolites indicate altered ruminal microbial populations and fermentations; an interruption of the tricarboxylic acid cycle; initial lack of glucogenic substrates; mobilization of body reserves; the potential alteration of electron transport chain; influence on urea synthesis; alteration of nervous system, inflammatory response, and immune cell function.
A Secure Lightweight Mutual Authentication Scheme in Social Industrial IoT Environment
Authors: Amor Arij Ben , Jebri Sarra , Abid Mohamed , Meddeb Aref 
Published: May 2022

Abstract
The Social Industrial Internet of Things (SIIoT) is a new paradigm that integrates social networking features into the Industrial IoT (IIoT) environment to enforce efficient and effective service discovery and collaboration between smart IoT objects in a friendly and scalable way. Therefore, in such environment, the establishment of secure and trust communication scheme is a crucial need between peer IoT devices having similar social profiles. In addition, the limited resource constrained IoT devices are unable to deal with huge computational overheads. To address these issues, we propose a novel solution offering secure Fog-based Social Industrial IoT (Fog-SIIoT) scheme. Fog-SIIoT guarantees mutual authentication, anonymity, and secure communication through a trust key agreement between social smart things. The proposed scheme is suitable for the social resource constrained IIoT as it only uses hash function, bitwise XOR operation, and symmetric cryptography. Comparing to correlative schemes, our solution presents many advantages in terms of security aspects, efficiency, social-awareness, and reduced computation overheads. Besides, the security analysis indicates that our scheme can withstand many known attacks.
Cellular mechanisms and effects of interleukin-4 receptor alpha blockade in a novel murine model of conjunctivitis evoked by skin inflammation
Authors: Han Hongwei , Cummings Sheila , Shade Kai-Ting C , Johnson Jennifer , Qian George , Gans Joseph , Shankara Srinivas , Escobedo Javier , Zarazinski Erik , Bodinizzo Renee , Bryce Paul , Hicks Alexandra 
Published: May 2022

Abstract
Ocular surface diseases, including conjunctivitis, are recognized as a common comorbidity in atopic dermatitis (AD) and also occur at an increased frequency in AD patients treated with biologics targeting interleukin-4 receptor alpha (IL-4Ra) or IL-13. However, the inflammatory mechanisms underlying this pathology are unknown. Here, we developed a novel mouse model of skin inflammation-evoked conjunctivitis and showed that it is dependent on CD4+ T cells and basophils. Blockade of IL-4Ra partially attenuated conjunctivitis development, downregulated basophil activation and led to a reduction in expression of genes related to type 2 cytokine responses. Together, these data suggest that an IL-4Ra-basophil axis plays a role in the development of murine allergic conjunctivitis. Interestingly, we found a significant augmentation of a number of genes that encode tear proteins and enzymes in anti-IL-4Ra-treated mice, which may underlie the partial efficacy in this model and may represent candidate mediators of the increased frequency of conjunctivitis following dupilumab in AD patients.
Sports Participation and Obesity in Children with Bicuspid Aortic Valve
Authors: Baleilevuka-Hart Marica E. , Khader Ayesha , Cesar Gonzalez de Alba , Holmes Kathryn W. , Huang Jennifer 
Published: May 2022

Abstract
Children with congenital heart disease (CHD), including bicuspid aortc valve (BAV) are at an increased risk of obesity and sedentary behaviors. These factors track strongly into adulthood, and are associated with increased morbidity and mortality. We aimed to describe predictors of obesity and sports participation in children with BAV. We performed a cross sectional study of children between the ages of 8 and 17 years with isolated BAV at Oregon Health & Science University. We excluded those with other CHD, genetic conditions, prior aortic valve or ascending aortic replacement and inability to ambulate independently. Parents were contacted to complete a phone survey examining level of daily activity and participation in competitive sports. Demographic information including gender, age and body mass index were collected from the electronic medical record. Controlling for age, logistic regression was performed with obesity as an independent variable. In total, 110 individuals participated in telephone surveys. The prevalence of obesity was 17% compared to state reported prevalence of 12.9%. The prevalence of obesity amongst athletes was 9% compared to 28% in non-athletes. In adjusted univariate analysis, participation in competitive sports was associated with decreased likelihood of obesity (OR 0.24, CI 0.078-0.74). There were no adverse events. Sports participation in children with BAV is associated with decreased obesity. Pediatric cardiologists should encourage sports participation rather than restrict in.
Research on Factors Influencing the Non-suicidal Self-injury Behaviors among Adolescents in China based on the DEMATEL-TAISM Method
Authors: Lan Zhensong , Pau Kee , Yu Hapsah Md , Huang Xuefang 
Published: May 2022

Abstract
Purpose: To analyze the influencing factors of adolescent NSSI behavior and their interrelationships, and to establish a total influencing factor model. Methods: Through literature review, semi-structured interview and expert consultation, the influencing factors of adolescent NSSI behavior in Guangxi, China were identified, and a total adversarial multi-level interpretive structure model of influencing factors of adolescent NSSI behavior was constructed based on DEMATEL-TAISM methods.Results: This paper intuitively shows the influencing factors and action paths of adolescents' NSSI behavior, and analyzes the system logic of the elements, as well as the relationship between the elements of the model. At last, some suggestions are put forward to provide ideas for the intervention service of adolescent NSSI behavior in Guangxi Province, China.
Time-dependent numerical methods for the quantum hydrodynamic model for semiconductor devices
Authors: Gardner Carl L. 
Published: May 2022

Abstract
Numerical methods are developed for the time-dependent smooth quantum hydrodynamic (QHD) model for semiconductor devices by solving the underlying hyperbolic gas dynamical part of the transport equations with a third-order WENO method, treating the quantum mechanical terms as source terms; the parabolic heat conduction term using the TRBDF2 method; and the elliptic Poisson equation using PCG. These are the first time-dependent simulations of the smooth QHD model, and the first time-dependent simulations of any QHD model at 300 K. Time-dependent simulations of the resonant tunneling diode to steady state are presented, which show realistic negative differential resistance (the experimental signal of quantum resonance) in the current-voltage curve.
Analysis of spatial and temporal impact differences of birth rate in mainland China
Authors: Zhang Jinwei , Ding Shuzhen , Hu Xijian 
Published: May 2022

Abstract
The continuing decline in the birth rate has led to a serious problems, such as the disproportion population structure, severe aging population, which has restricted the country’s economic development. To understand more deeply the geographical differences and influencing factors of the birth rate, this paper collects and organizes the birth population data of 31 provinces in mainland China from 2014 to 2019. The national region is divided into seven natural geographical regions to obtain the spatial hierarchy, and a hierarchical Bayesian spatio-temporal model is established. The model parameters are estimated by the INLA algorithm. The results show that there are significant spatial and temporal differences in birth rates in mainland China, which are reflected mainly in the combination of economic, spatial, temporal, and spatio-temporal interaction effects. With the increase of per capita disposable income, population’s fertility intention decreases, but regional GDP still has a high positive impact on the local birth rate. The spatial and temporal pattern of the birth rate is the remaining explanation. In spatial dimension, the northeast is low, the northwest and southwest are high, and the birth rate has an upward trend from east to west. These trends are caused by unbalanced economic development, different fertility attitudes and differences in fertility security, reflecting regional differences in spatial effects. In the time dimension, from 2014 to 2019, China’s birth rate showed an overall downward trend. However, all regions except the northeast saw a significant but temporary increase in birth rates in 2016 and 2017, reflecting the time effect difference in birth rates.
Amplified Multimode Wave Mixing: from Chaos to Order
Authors: An Haechan , Owens Hal , Ather Hamza , Shakouri Ali , Hosseini Mahdi 
Published: May 2022

Abstract
The dynamics of optical nonlinearity in the presence of gain and feedback can be complex leading to chaos in certain regimes. Temporal, spectral, spatial, or polarization instability of optical fields can emerge from an optical χ (2) or χ (3) nonlinear medium placed between two cavity mirrors or before a single feedback mirror. The complex mode dynamics, high-order correlations, and transition to chaos in these systems are not well known. We consider a χ (3) medium with amplified four-wave mixing process and study noise and correlation between multiple optical modes. Although individual modes show chaotic behavior, we observe relative intensity noise reduction close to the standard quantum noise, limited by the camera speed. We observe a relative noise reduction of more than 20 dB and fourth-order intensity correlation between four spatial modes. More than 100 distinct correlated quadruple modes can be generated using this process.
Information needs of parents of children with congenital anomalies across Europe: a EUROlinkCAT survey
Authors: Marcus Elena , Latos-Bielenska Anna , Jamry-Dziurla Anna , Barišić Ingeborg , Cavero-Carbonell Clara , Hond Elly Den , Garne Ester , Genard Lucas , Santos Ana João , Lutke L Renée , Dias Carlos Matias , Pedersen Christina Neergaard , Neville Amanda J , Niemann Annika , Odak Ljubica , Pierini Anna , Rico Juan , Rissmann Anke , Rankin Judith , Morris Joan K 
Published: May 2022

Abstract
BackgroundParents of children who have a congenital anomaly can experience significant worry about their child’s health. Access to clear, helpful, and trustworthy information can provide a valuable source of support. In this study the information needs of parents/carers of children with congenital anomalies were explored across Europe.MethodA cross-sectional online survey was developed in nine languages to measure parents’ information needs, including: (1) the ‘helpfulness’/’trustworthiness’ of information received from eight relevant sources, and (2) overall satisfaction with information received. Parents/carers of children (0-10 years) with cleft lip, spina bifida, congenital heart defect [CHD] requiring surgery, and/or Down syndrome were recruited online via relevant organisations in 10 European countries from March-July 2021. Quantitative analyses using multivariable logistic regressions were performed. Results1,070 parents/carers of children with a cleft lip (n=247), spina bifida (n=118), CHD (n=366), Down syndrome (n=281), and Down syndrome with CHD (n=58) were recruited in Poland (n=476), the UK (n=120), Germany (n=97), the Netherlands/Belgium (n=74), Croatia (n=68), Italy (n=59), other European countries (n=92), and not specified/non-European countries (n=84). Most participants were mothers (92%) and aged 31-40 years (71%). Participants were most likely to rate support groups (63%), patient organisations (60%), specialist doctors/nurses (58%), and social media (57%) as ‘very helpful’ information sources. ‘Very trustworthy’ ratings remained high for specialist doctors/nurses (61%), however, they declined for support groups (47%), patient organisations (48%), and social media (35%). Germany had the highest proportion of participants who were ‘very satisfied’ (44%, 95% CI=34%-54%) with information, whereas this percentage was lowest in Croatia (11%, 95% CI=3%-19%) and Poland (15%, 95% CI=11%-18%). Parents of children with Down syndrome had significantly lower satisfaction ratings than parents of children with CHD; 13% (95% CI=8%-18%) reported being ‘very satisfied’ compared to 28% (95% CI=23%-33%) in the CHD group. ConclusionsFindings suggest that informal sources of information (e.g. support groups) are of value to parents, however, they are not deemed as trustworthy as specialist medical sources. Satisfaction ratings differed across countries and by anomaly, and were particularly low in Croatia and Poland, as well as for parents of children with Down syndrome, which warrants further investigation.
Effect of external mean flow on sound transmission loss of double-walled porous functionally graded magneto-electro-elastic sandwich plates
Authors: Sirimontree Sayan , Thongchom Chanachai , Saffari Peyman Roodgar , Saffari Pouyan Roodgar , Refahati Nima , Jearsiripongkul Thira , Keawsawasvong Suraparb 
Published: May 2022

Abstract
In the present study, the sound transmission loss through the air-filled rectangular double-walled sandwich smart magneto-electro-elastic (MEE) plates with porous functionally graded material (PFGM) core layer under initial external electric and magnetic potentials, and external mean airflow is studied using the third-order shear deformation theory (TSDT). Three states of uneven porosity distributions are considered for PFGM core layer which are supposed to vary along the in-plane and thickness directions based on the power-law model. The derivation of vibroacoustic equations in the form of coupled relations is realized by implementing Hamilton’s principle. An analytical approach, i.e. second velocity potential, is exploited to solve them in conjunction with double Fourier series, and the final result is the desired sound transmission loss (STL) equation. The developed solution is investigated in terms of its accuracy and precision via a comparison with other available data in existing research. Parameter studies reveal the impacts of the initial electric and magnetic potentials, porosity distributions, incident angles, acoustic cavity depth on STL through the double-walled sandwich smart MEE plates.
Functional inhibition of the StERF3 gene by dual targeting through CRISPR/Cas9 enhances resistance to the late blight disease in Solanum Tuberosum L.
Authors: Razzaq Hafiza Arooj , Ijaz Siddra , Haq Imran Ul , Khan Iqrar Ahmad 
Published: May 2022

Abstract
Background
The use of disease-resistant cultivars is the best solution to get their maximum yield potential and avoid fungicide application. There is no doubt about the contribution, and use of R genes (resistance genes) in resistance development in plants, while S genes (susceptibility genes) also hold a strong position in pathogenesis by resistance repression, and their loss of function contributes to enhanced resistance. Hence, we attempted to knock out the function of StERF3 in potatoes through CRISPR/Cas9 based genome editing and investigated the CRISPR/Cas9 approach as strategic control against late blight disease in potato plants.
Methods and results
The StERF3 gene was edited in late blight susceptible cv. Lady Rosetta. Full allelic edited plants were identified through DnpI and N1aIV mediated restriction digestion and then further analyzed through Indel Detection by Amplicon Analysis. Sequence analysis of targeted plants for indel identification showed full allelic editing. The detached leaf assay of full allelic edited plants demonstrated the role of the StERF3 gene in susceptibility to late blight in potatoes. In planta disease assay also showed reduced, slowed, and delayed disease progression in StERF3-loss-of-function mutants in comparison to wild-type (control) plants. Less fungal biomass was quantified in knockouts through Real-time qPCR that supported less susceptibility of edited plants to late blight. Besides, relatively high expression of pathogens-related genes, StPR1, and StNPR1 were also observed in StERF3-loss-of-function mutants compared to the corresponding control.
Conclusion
The results showed the functional inhibition of StERF3 genes using the CRISPR/Cas9 approach. The functional knockouts of StERF3 generated potato plants revealed enhanced resistance against Phytophthora infestans and thereby demonstrated as best strategic control for late blight disease in potato plants.