bluuebunny/crossref_metadata_2025_split huggingface dataset:
Restrictions of Freedom of Assembly and Association in Slovenia during COVID-19 Pandemic
Authors: Kużelewska Elżbieta , Podolak Małgorzata 
Published: July 2022

Abstract
Slovenia is one of the European Union Member States which disproportionately restricted political rights during the COVID-19 pandemic. Since the new government of Prime Minister Janez Janša came to power in March 2020, the anti-government and anti-lockdown protests have been taking place across the country. The pandemic-related restrictions have been introduced by government’s ordinances. They have greatly limited political rights of citizens, in particular the right to public assembly and association. Citizens’ dissatisfaction with the government’s policies and inadequate handling of the epidemic, resulting in undue restrictions on liberty and other fundamental rights, led to the filing of petitions to the Constitutional Court. The Constitutional Court, resolving the dispute between citizens and the government, ruled that government regulations implementing restrictions on fundamental rights, particularly the rights to public assembly and association, were unconstitutional in several cases.
Actitudes lingüísticas hacia el inglés británico y americano en alumnos de la especialidad de Inglés de la Universidad Nacional Mayor de San Marcos
Authors: Cárdenas Cornelio Yony , Esquivel Villafana Jorge 
Published: July 2022

El objetivo de esta investigación es abordar el fenómeno de las actitudes lingüísticas en estudiantes de la especialidad de Inglés. Esto permitirá distinguir las actitudes de los discentes respecto del inglés americano y el inglés británico en contextos hispanohablantes. El estudio de las actitudes lingüísticas resulta relevante en la sociolingüística porque la riqueza de información sobre el funcionamiento del idioma está en su relación social con la comunidad” (Holmes, 2013, pp. 1-2). Así, este tipo de trabajo comprende tres áreas: las actitudes cognitivas, conductuales y afectivas (Zanna y Rempet, 1988), las que son consideradas en el presente estudio. Se utilizará como medio de investigación la encuesta del método de las máscaras y la observación. Las actitudes lingüísticas de los alumnos de la especialidad de Inglés de la UNMSM respecto al inglés americano y británico son positivas por el prestigio que ambas lenguas tienen y por las motivaciones actitudinales integradoras e instrumentales. Respecto a las variables sociolingüísticas en relación con las actitudes, solo se ha podido encontrar una relación de influencia significativa en la edad. En el análisis de la técnica de las máscaras, se evidenció un promedio mayor de aceptación en casi todos los atributos respecto del inglés británico.
La configuración de los personajes femeninos en la estructura polifónica en La casa de cartón de Martín Adán
Authors: Castañeda Tantaleán Shirley Janette , Del Castillo Kusterman Eduardo Humberto 
Published: July 2022

La casa de cartón de Martín Adán se desarrolla a inicios del siglo XX. Sus personajes citadinos permanecen en una realidad distante, casi existencialista. El presente trabajo estudia la configuración de los personajes femeninos en la estructura polifónica, aspecto formal que se advierte en dicha obra. Siguiendo los aportes de Mijael Bajtin y Oswald Ducrot, se realiza un análisis cualitativo del texto en el marco de la teoría literaria, de la teoría lingüística de la enunciación y de los estudios de género. La investigación concluye que un locutor masculino enuncia una imagen conservadora de la mujer que refuerza patrones de género sostenidos en mitos sociales.
Partisipasi Masyarakat Minangkabau Pada Implementasi Program Pariwisata Dalam Pemberdayaan Masyarakat Islam
Authors: Defrinal  , Nasor M , Karni Awis , Mukmin Hasan 
Published: July 2022

Pada dasarnya Islam adalah agama permberdayaan sebagaimana dalam Al Quran surat Ar Ra’du ayat 11. Pemberdayaan merupakan proses pengembangan partisipasi, terutama dalam pengelolaan pariwisata berbasis masyarakat yang membutuhkan keterlibatan penuh masyarakat sehingga berdampak pada kesejahteraan. Adapun masalah yang akan diteliti adalah: Bagaimana partisipasi masyarakat pada implementasi program pariwisata dalam pemberdayaan masyarakat Islam?. Penelitian ini bertujuan untuk: Mendeskripsikan dimensi partisipasi masyarakat pada implementasi program pariwisata dalam pemberdayaan masyarakat Islam. Penelitian ini didesain menggunakan metode pendekatan kualitatif dengan jenis penelitian Studi Kasus. Teknik “porposive sampling” termasuk ke dalam nonprobality sampling yaitu pengambilan subjek kajian bergantung kepada peneliti melihat subjek tersebut.
Partisipasi masyarakat dalam seluruh aktifitas program pariwisata dilihat pada dimensi, Decision Making, Implementations, Benefits dan Evaluation. Anggota masyarakat dalam pengelolaan pariwisata di Lubuk Nyarai berpartisipasi pada seluruh dimensi, sehingga memiliki dampak pada kesejahteraan sosial, budaya, lingkungan dan ekonomi. Hal ini menjadi acuan bagi pemerintah dalam pengelolaan pariwisata pada pemberdayaan masyarakat islam, dengan melibatkan seluruh anggota masyarakat pengelola dalam setiap dimensi partisipasi, serta memberikan kepercayaan kepada anggota masyarakat untuk dapat merefleksikan aksinya pada tindakan kolektif melalui pelaksanaan kegiatan bersama.
Impilikasi Kapitalisme Ekonomi Pada Petani Melayu Perkebunan Kopi Rakyat di Sumatera Selatan
Authors: Ayu Ritawati Raden 
Published: July 2022

Modern economic capitalism has long engulfed smallholders in rural coffee plantations in South Sumatra. Intangibly, capitalism is always neatly wrapped up in goodness with many interests. The meaning of goodness here, how doers of economic capitalism with the spirit of morality have succeeded in deceiving coffee plantations farmers to become melted and obedient.
This research is to find out the impact experienced by coffee plantation farmers who consciously form conflicts of interest and power. And the extent of the government's role in saving coffee farmers from the snares of dependency and hegemony of poverty. The field study was conducted in response to the behaviors and habits of the informants and the local culture that was observed on an ongoing basis. Then analyzed with descriptive qualitative methods based on the semantic relationship between variables.
The results of the study prove that poverty that occurs in coffee farmers due to various factors, such as; historical elements as a result of colonial-feudalism, financial-industrial and technological-industrial dependency that made poor farmers helpless. Farmer expenditure, which was originally subsistence life, is increasingly in the form of money. No wonder consumerism is rampant and has become a new culture in rural communities. Increased habit of indebted to coffee bean collectors because of increasing population and economic pressure due to the inability of coffee farmers to adapt to the buying and selling economy. Where debt payments are made in installments when there is a coffee harvest with a longer payment term. Finally, the transformation of interests has succeeded in initiating the idea of ??mastering the economy of coffee farmers on moral and ethical ties for the values ??of the welfare of farmers who are hereditary and empowered for generations.
Combined myocardial perfusion scintigraphy and computed tomography: diagnostic and prognostic value in coronary artery disease
Authors: Gulya M. O. , Mochula A. V. , Maltseva A. N. , Zavadovsky K. V. 
Published: July 2022

Modern imaging techniques occupy an important place in the diagnosis, selection of treatment and prognosis of patients with coronary artery disease. Hybrid imaging is a combination of two sets of diagnostic data that complement and enhance each other by comparing anatomical and functional characteristics. As a rule, hybrid imaging is synergistic, that is, more powerful, since the addition of new information leads to an increase in the sensitivity and specificity of each of the modalities separately.The review provides brief information on the diagnostic efficacy of myocardial perfusion scintigraphy (MPS), computerized tomography (CT) coronary angiography in comparison with invasive coronary angiography with fractional flow reserve. The diagnostic and prognostic significance of assessing calcium index with MPS, as well as CT coronary angiography combined with MPS in the diagnosis, risk stratification and prognosis of patients with coronary artery disease, is characterized in detail. A separate section is devoted to the importance of hybrid imaging in making decisions about myocardial revascularization.
Intensification of lipid-lowering therapy in very high-risk patients: potential of combination with PCSK9 inhibitors
Authors: Sedykh D. Yu. , Kashtalap V. V. , Khryachkova O. N. , Petrova T. S. , Barbarash O. L. 
Published: July 2022

Aim. To assess the efficacy and safety of 6-month combined lipid-lowering therapy with a PCSK9 inhibitor in patients with very high cardiovascular risk (CVR).Material and methods. This prospective, open-label, single-center exploratory research study with active treatment included 5 outpatients with very high CVR. So, 80% of patients had prior coronary artery disease, 20% peripheral arterial disease, and 60% old myocardial infarction. The key inclusion criterion was the failure to achieve the target low-density lipoprotein cholesterol (LDL-C) <1,4 mmol/l with high-intensity statin monotherapy at the maximal tolerated doses or combination therapy with ezetimibe. On a regular basis, all included patients took atorvastatin 40-80 mg/day or rosuvastatin 20-40 mg/day, or pitavastatin 2-4 mg/day. In addition, 2 patients received a statin in combination with ezetimibe 10 mg/day. Patients were followed up for 6 months as follows: every 2 weeks, with a lipid profile monitoring, subcutaneous injections of alirocumab at a dose of 150 mg/ml were performed. Additionally, clinical and laboratory indicators of the safety of therapy were evaluated.Results. After 6 months, with the combined lipid-lowering therapy with alirocumab, a decrease in median LDL-C from 4,3 (4,11-4,67) to 1,27 (1,06-1,47) (p=0,001) mmol/l, total cholesterol from 6,1 (6-7) to 3,7 (3,5-3,9) (p=0,018) mmol/l, atherogenic index from 3,2 (3-3,26) to 0,8% (0,8-1,5) (p=0,001). There was no significant decrease in median triglycerides and an increase in median high-density lipoprotein cholesterol. Six-month lipid-lowering therapy with a PCSK9 inhibitor had no adverse events and made it possible to achieve a maximum decrease in LDL-C by an average of 75,4% already by 4 months of treatment in actual clinical practice.Conclusion. Six-month combined lipid-lowering therapy with alirocumab 150 mg subcutaneously every 2 weeks in very high-risk patients allows the majority of patients to achieve target LDL-C values.
Prevalence of familial hypercholesterolemia and hyperlipoproteinemia(a) in patients with premature acute coronary syndrome
Authors: Chubykina U. V. , Ezhov M. V. , Afanas’eva O. I. , Klesareva E. A. , Tmoyan N. A. , Pokrovsky S. N. 
Published: July 2022

Aim. To evaluate the prevalence of familial hypercholesterolemia (FH) and hyperlipoproteinemia(a) (HLP(a)) in patients with premature acute coronary syndrome (ACS).Material and methods. The study included 120 patients with ACS up to 60 years (mean age, 53±7 years, 104 (87%) men) and 44 people from the comparison group without atherosclerotic cardiovascular diseases and dyslipidemia (mean age, 48±11 years, 19 (43%) men). All patients with ACS underwent coronary angiography. The lipid profile and lipoprotein(a) (Lp(a)) were determined in all patients.Results. The prevalence of HLP(a) in patients with premature manifestation of ACS was 41% (n=49), possible FH — 25% (n=30), combination of FH and HLP(a) — 13% (n=15). In the comparison group, an increased concentration of Lp(a) was detected in 14% (n=6). Based on the analysis of operating characteristic curves, Lp(a) ≥30 mg/dL had the maximum significance for ACS with a sensitivity of 40% and a specificity of 86% (area under the curve, 0,6; 95% confidence interval (CI), 0,5-0,7, p<0,05), and Lp(a) >15 mg/dl was associated with two or more coronary artery lesions with a sensitivity of 67% and a specificity of 65% (area under the curve, 0,7; 95% CI, 0,6-0,7, p<0,01). On logistic regression analysis, age (odds ratio (OR). 1,1; 95% CI, 1,0-1,2, p<0,05), smoking (OR, 7,5; 95% CI, 2,5-22,0, p<0,001) and Lp(a) ≥30 mg/dl (OR, 6,7; 95% CI, 1,1-39,7, p<0,05) are independently associated with premature ACS. Only Lp(a) ≥15 mg/dL was associated with multivessel coronary artery disease in these patients (OR, 3,8; 95% CI, 1,52-9,74, p<0,01).Conclusion. Every fourth patient with premature ACS has FH, while almost every second has HLP(a), and every eighth has a combination of FH and HLP(a). HLP(a) is associated with ACS up to 60 years of age and multivessel coronary artery disease in these patients.
Translation, Cross-Cultural Adaptation, and Psychometric Validation of the Russian Coronary Artery Disease Education Questionnaire II (CADE-Q II) in chronic coronary syndrome patients
Authors: Laskova A. I. , Ghisi G. L. M. , Lopatin Yu. M. 
Published: July 2022

Aim. This study sought to translate, cross-culturally adapt, and psychometrically validate the Coronary Artery Disease Education Questionnaire II (CADE-Q II) in Russian.Material and methods. Independent translations and back-translations of the CADE-Q II were conducted by bilingual health professionals and certified translators, respectively. Experts met to consider cultural relevance of the items to Russian patients. The finalized version was then pilot tested in a group of patients to assess understanding and time to complete the tool. Following these steps, 303 patients with a diagnosis of stable coronary artery disease treated in the Outpatient Cardiology Department between April and November 2021 completed the CADE-Q II. The following psychometric properties were evaluated: confirmatory factor analysis, internal consistency (assessed by Cronbach's alpha), test-retest reliability (ICC), and criterion validity (assessed through the association with CADE-Q II and The Self Care of Coronary Heart Disease Inventory and SF-36 scores, among other characteristics from the participants including educational level).Results. After items were translated, revised, culturally adapted and finalized, 30 patients took 30 minutes to complete the CADE-Q II during pilot test and questionnaire was considered understandable by all. Factor analysis (Kaiser-Meyer-Olkin =0.692 and Bartlett's criterion of Sphericity <0.05) revealed four factors, all internally consistent and aligned with the original version of the questionnaire. Cronbach's alpha of subscales ranged from 0.61 to 0.88 and ICC was 0.81. Criterion validity was confirmed by significant differences in total CADE-Q II scores by participants' educational level and correlations between CADE-Q II and The Self Care of Coronary Heart Disease Inventory scores (r=0.251, p<0.05).Conclusion. The Russian CADE-Q II presented sufficient validity and reliability for use to assess disease-related knowledge of chronic coronary syndrome patients in Russia.
Association of various lipid parameters with premature coronary artery disease in men
Authors: Tyurina A. V. , Afanas’eva O. I. , Klesareva E. A. , Tmoyan N. A. , Razova O. A. , Ezhov M. V. , Pokrovsky S. N. 
Published: July 2022

Aim. To assess the relationship between premature coronary artery disease (CAD) and various lipid parameters.Material and methods. This retrospective longitudinal study included 166 men aged 57±9 years with coronary CAD with onset before age of 55. The control group consisted of 62 men (60±8 years old) who did not have CAD and peripheral arterial disease. In all patients, data on following lipid profile parameters were collected: total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), non-high-density lipoprotein cholesterol (non-HDL-C) and lipoprotein(a) (Lp(a)) at the time of CAD onset, while in control group patients — at the first visit to the A.L. Myasnikov Institute of Clinical Cardiology. These indicators were measured in blood plasma at the time of enrollment in all patients. In addition, the concentration of LDL-C corrected for Lp(a)-cholesterol (LDL-Ccorr) was calculated. Hypercholesterolemia was diagnosed with an initial level of TC >5 mmol/l, or LDL-C ≥3,0 mmol/l, or non-HDL-C ≥3,8 mmol/l, while hyperlipoproteinemia(a) (HLP(a)) — at the level of Lp(a) ≥30 mg/dl.Results. Lipid metabolism disorders were significantly more common in patients with premature CAD compared to the control group. Lp(a) concentration ≥30 mg/dl, along with elevated levels of non-HDL-C or LDL-Ccorr, were associated with premature CAD, regardless of heredity and smoking, in the general cohort of examined men. Kaplan-Meier survival analysis showed that any type of lipid metabolism disorder was associated with an increased risk of premature CAD. In addition, patients with isolated elevated Lp(a) concentrations lived to the CAD onset 8 years earlier — 47 vs 55 years, p<0,02. The probability of premature CAD was maximum when the elevated level of non-HDL-C and HLP(a) was combined (hazard ratio, 2,91 (95% CI 1,96-4,33), p<0,0001).Conclusion. HLP(a) is an independent factor of premature CAD, even with normolipidemia, which confirms the need for routine measurement of Lp(a) in clinical practice.
Ultrasound Atherosclerosis Burden Score as a tool for predicting adverse cardiovascular events in patients with various cardiovascular risks aged 40-64 years
Authors: Genkel V. V. , Kuznetcova A. S. , Pykhova L. R. , Shaposhnik I. I. 
Published: July 2022

Aim. To investigate the prognostic significance of the Atherosclerosis Burden Score (ABS) in relation to the development of major adverse cardiovascular events in patients of different cardiovascular risks (CVR) aged 40 to 64 years.Material and methods. Men and women aged 40 to 64 years were included in the study. All the patients underwent duplex scanning of the carotid arteries and lower limb arteries. The total ABS was calculated by assessing the presence of plaque in the carotid and femoral bifurcations on both sides. The combined endpoint was cardiovascular death, nonfatal myocardial infarction, nonfatal stroke, coronary revascularization, or peripheral artery revascularization.Results. The study included 232 patients who met the inclusion criteria, with a median age of 55,0 years. Very high CVR was established in 94 (40,5%) patients, while high CVR — in 48 (20,7%) patients, and low and intermediate CVR — in 90 (38,8%) patients. The follow-up period lasted 23,6 (15,5; 51,2) months, providing 632,6 patient-years of follow-up. Events within composite endpoint occurred in 28 (12,1%) patients. Increased cumulative risk of adverse cardiovascular events was observed for ABS ≥2, with a significant increase in relative risk (RR) for ABS ≥3. According to Cox regression analysis, ABS 3 was associated with a 3,71-fold (95% CI 1,18-11,6; p=0,025) increase in the RR of adverse cardiovascular events after adjustment for sex, age, baseline CVR, obesity, smoking, diabetes, CAD, a history of myocardial revascularization, type 2 diabetes, drug therapy, and levels of non-high density lipoprotein cholesterol, highly sensitive C-reactive protein, and glomerular filtration rate.Conclusion. In patients of various CVR aged 40-64 years, an ABS ≥3 was associated with a 3,71-fold (95% CI, 1,18-11,6; p=0,025) increase in relative risk of adverse cardiovascular events after adjusting for potential confounders, including sex, age, baseline CVR, CAD, and type 2 diabetes.
Results of pilot remote monitoring of heart failure patients
Authors: Pyrikova N. V. , Mozgunov N. A. , Osipova I. V. 
Published: July 2022

Aim. To analyze the results of remote monitoring of patients with decompensated heart failure (HF) based on the assessment of quality of life (QOL), self-care ability and adherence to treatment 3 and 6 months after discharge from the hospital.Material and methods. The first group (experimental) consisted of 70 patients who, along with the approved healthcare standard, underwent measures according to the developed model for managing HF patients, including remote monitoring. The second group (control) included 65 patients who received care according to generally accepted algorithms for managing HF patients. In the study group, there were 46% men (69,6±9,4 years) and 54% women (71,7±9,9 years). The control group also included 46% men (70,6±9,1 years) and 54% women (73,0±10,3 years). Class I HF in the first group had 4%, while in the second — 3%; class II HF in both groups occurred in 11%; class III in the first group — 43%, in the second group — 54%, class IV HF in the first group — 41%, in the second group — 32% of patients. We conducted a standard clinical examination, assessed QOL, self-care ability, and adherence to treatment.Results. In the first group, after 3 months, compared with the baseline, the average Minnesota Satisfaction Questionnaire (MSQ) score was lower by 37 (p=0,037), while after 6 months — by 33,6 (p=0,026). After 3 months according to the MSQ, the QOL in the second group was higher by 7,9 points (p=0,0001); according to the Morisky-Green test — lower by 1,2 points (p=0,0003); according to the self-care questionnaire — higher by 4,7 points (p=0,0001) than in the first group. After 6 months, MSQ score in the second group was higher by 10,4 points (p=0,0001), according to the Morisky-Green test — lower by 1,8 points (p=0,0003); according to the self-care questionnaire — higher by 5,6 points (p=0,0001) than in the study group.Conclusion. The developed model for managing HF patients using remote monitoring, in comparison with the generally accepted standards, has led to an increase in QOL, adherence to treatment and self-care ability of patients.
Advantages of using a portable cardiac monitor in outpatients with paroxysmal atrial fibrillation
Authors: Khalikova M. A. , Tsaregorodtsev D. A. , Beraya M. M. , Sedov A. V. , Vasyukov S. S. 
Published: July 2022

Aim. To study the advantages of using a portable electrocardiographic (ECG) monitor in outpatients with paroxysmal atrial fibrillation (AF).Material and methods. We examined 88 patients (26 men, 62 women, mean age, 63 [57;68] years) with paroxysmal AF with an average frequency of arrhythmia episodes of 1,0 [0.3;3.75] per month. Forty three (49%) patients were included in the remote monitoring (RM) group using the ECG Dongle monitor, and 45 (51%) patients were included in the conventional monitoring (CM) group. Patients underwent scheduled examinations 2, 6 and 12 months after the start of therapy. Unscheduled consultations were carried out in case of AF recurrence. Patients from the RM group, using portable cardiac monitor, additionally self-registered ECG 1 time per week and in case of symptoms suggestive of AF. ECG strips were sent to the clinical investigator for analysis.Results. With the help of portable cardiac monitor, 2477 ECG strips were collected and analyzed: 2159 (87,2%) — sinus rhythm, 318 (12,8%) — AF and atypical atrial flutter. Forty four episodes of AF in 3 patients were asymptomatic. In addition, 211 (8,5%) sinus rhythm ECG strips were recorded by 13 patients with symptoms suggestive of AF. In the RM group, 7 (16%) patients were hospitalized due to recurrent AF, while in the CM group, 20 (44%) patients (p=0,004). The total number of emergency hospitalizations was 8 and 29 in the RM and CM groups, respectively. The number of patients who called an ambulance was significantly lower in the RM group: in the CM group, 37 calls for an ambulance were made by 22 patients, while in the RM group — 12 patients made 15 calls (p=0,044). The proportion of calls followed by hospitalization (40 vs 70%, p=0,043) was significantly lower in the RM group.Conclusion. Remote ECG monitoring using the ECG Dongle system is a useful way to monitor patients with paroxysmal AF, which make it possible to register asymptomatic AF episodes, differentiate the causes of palpitations, and significantly reduce the frequency of emergency calls and hospitalizations.