bluuebunny/crossref_metadata_2025_split huggingface dataset:
Catalytic Peptides: the Challenge between Simplicity and Functionality
Authors: Carvalho Sara , Peralta Reis David Q. , Pereira Sara V. , Kalafatovic Daniela , Pina Ana Sofia 
Published: August 2022

AbstractEnzymes’ machinery has been an inspiration for chemists. Peptides are vital players in the origin of life, being ancestors of complex enzymes. Even short peptides that are simple in terms of the number of residues are reprogrammable and built to encode chemical information for catalysis, substrate recognition, and molecular interactions. The combinatorial search of the sequence space led to identifying peptides with catalytic activities. However, most of these sequences remain unevolved, leading to modest rates in aqueous media. Short peptides present conformational flexibility, which is their primary liability for catalysis. To overcome this, supramolecular motifs and secondary frameworks are used as scaffolds to incorporate catalytic residues and improve their efficiency. This review discusses the strategies used to discover and evolve catalytic function in short peptides beyond the de novo design and the advantages of using these approaches to enhance catalysis.
Laparoscopic port site Richter's hernia after robot‐assisted radical prostatectomy
Authors: Tobe Taisuke , Yuen Keiji , Yasufuku Tomihiko , Uematsu Riku , Miyazaki Akira , Yamashita Masuo 
Published: August 2022

IntroductionPostoperative small bowel obstruction is a rare complication. One of its less frequent causes is port site hernia. We report a case of Richter's port site hernia in a patient who underwent robot‐assisted radical prostatectomy.Case presentationA 73‐year‐old man who underwent robot‐assisted radical prostatectomy noted acute abdominal pain and nausea on the 11th postoperative day. Computed tomography scans revealed dilated small bowel loops. Adhesive ileus was initially suspected, which was relieved with conservative management, including ileus tube insertion. However, his symptoms worsened. Thus, a laparotomy was performed. The camera port wound was reopened, and the repaired fascia and small intestine were found incarcerated into the peritoneal defects. These findings were consistent with Richter's hernia.ConclusionPort site hernia was not detected on computed tomography scans. Patients presenting with small bowel obstruction following laparoscopic surgery should be evaluated for port site hernia, and surgical management should be considered.
Longitudinal paths between parents' use of rewards and young adolescents' moral traits and prosocial behaviors
Authors: Carlo Gustavo , Samper Paula , Malonda Elisabeth , Mestre Anna L. , Tur‐Porcar Ana M. , Mestre Maria V. 
Published: August 2022

AbstractBackgroundAlthough prior research shows supportive evidence that parental practices are associated with adolescents' prosocial behaviors, limited evidence exists on the effects of parents' use of social and material rewards on distinct forms of prosocial behaviors, and the mediating effects of sociocognitive and socioemotive traits in these relations.AimsThe present study was designed to examine the longitudinal relations among parents' use of social and material rewards, youth prosocial traits, and prosocial behaviors.Materials & MethodsParticipants were 417 adolescents (M age = 14.70 years; 225 girls) from Valencia, Spain who completed surveys on parents' use of social and material reward practices, prosocial moral reasoning, empathic concern, and six types of prosocial behaviors.ResultsPath analyses showed that parents' use of social rewards was indirectly, positively related to emotional, dire, altruistic, public (negatively), and compliant prosocial behaviors via empathic concern. The use of social rewards was also indirectly positively linked to altruistic prosocial behaviors via both empathic concern and prosocial moral reasoning. In contrast, parents' use of material rewards predicted less prosocial moral reasoning, which in turn, was linked to more altruistic, prosocial behaviors.Discussion and ConclusionsThe implications for parental socialization and self‐determination theories of prosocial and moral development are discussed.
Feasibility study of oxidized naringin as a novel crosslinking agent for crosslinking decellularized porcine Achilles tendon and its potential application for anterior cruciate ligament repair
Authors: Cheng Can , Peng Xu , Xi Linjie , Luo Yihao , Wang Yuhang , Zhou Yufan , Yu Xixun 
Published: August 2022

AbstractNaringin (Nar), a natural flavanone glycoside, has been shown to possess a variety of biological activities, including anti‐inflammatory, anti‐apoptotic, bone formation, and so forth. In this study, Nar was oxidized by sodium periodate and the oxidized naringin (ONar) was used as a novel biological crosslinking agent. In addition, ONar‐fixed porcine decellularized Achilles tendon (DAT) was developed to substitute anterior cruciate ligament (ACL) for researching a novel ACL replacement material. The ONar with a 24 h oxidation time had appropriate aldehyde group content, almost no cytotoxicity, and a good crosslinking effect. The critical characteristics and cytocompatibility of ONar‐fixed DAT were also investigated. The results demonstrated that 1% ONar‐fixed DAT exhibited good resistance to enzymatic degradation and thermal stability as well as suitable mechanical strength. Moreover, 1% ONar‐fixed specimens exhibited excellent L929 fibroblasts‐cytocompatibility and MC3T3‐E1‐cytocompatibility. They also promoted the secretion of hepatocyte growth factor (HGF) and basic fibroblast growth factor (bFGF) from fibroblasts and bone morphogenetic protein‐2 (BMP‐2) from osteoblasts. And they also showed the good anti‐inflammatory properties in vivo experiments. Our data provided an experimental basis for ONar as a new cross‐linking reagent in chemical modification of DAT and ONar‐fixed DAT for ACL repair.
Predicting positive and negative behaviors at the workplace: Insights from multi‐faceted perceptions and attitudes
Authors: Abdullah Hasan Oudah , AL‐Abrrow Hadi 
Published: August 2022

AbstractBehavior at the workplace is one of the most important factors that distinguishes one organization from another. The current study attempts to test two pathways through which positive and negative behavior at the workplace can be predicted. The positive path leading to positive behavior (i.e., task performance, organizational citizenship behavior [OCB]) is shaped by positive perceptions (i.e., perceived organizational justice, perceived organizational support, perceived organizational identity) and positive attitudes (i.e., organizational commitment, work engagement), while the negative path leading to negative behavior (i.e., counterproductive work behavior [CWB], turnover intentions) is shaped by negative perceptions (i.e., perceived organizational politics, perceived abusive supervision, perceived overqualification) and negative attitudes (i.e., job stress, job burnout). Data were collected from 1344 individuals working in various companies in the public sector (e.g., industrial, service, health, education) in Iraq. To achieve the purpose of the study, 16 hypotheses were tested. The results of the study supported positive and negative pathways of perceptions, attitudes, and behavior. The results also indicated that positive perceptions and attitudes are good predictors of negative behavior, while negative perceptions and attitudes also predict positive behavior. This indicates that obtaining the best results of behavior in the workplace should be through strengthening the package of positive variables and reducing the package of negative variables. Based on the results, the study discussed a number of theoretical and practical implications and offered a set of recommendations.
Are morphologies of SERS active substrates multifractals? An in‐depth study from multifractal detrended fluctuation analysis
Authors: Saha Somsubhra , Dutta Srimonti , Chowdhury Joydeep 
Published: August 2022

AbstractThis paper reports the first evidence that depicts multifractal nature of two different surface enhanced Raman scattering (SERS) active substrates of classes I and II, so fabricated from Langmuir–Blodgett and self‐assembly techniques. Multifractal detrended fluctuation analysis (MF‐DFA) has been performed from the field emission scanning electron microscopy and atomic force microscopy images of both the as fabricated SERS active substrates. Dependences of
on “q” together with the nonlinear variations of the classical scaling exponent
with “q” primarily reveal the multifractal nature of both the substrates. The singularity spectra for both the substrates of classes I and II exhibit bell‐shaped curves with finite spectral widths (W). Furthermore, the correlation coefficients (γ) and asymmetry indices (B) for the substrates have also been estimated from MF‐DFA. From these studies, we believe that multifractality may be considered as the hallmark of SERS active substrates, which to the best of our knowledge has been distinctively unveiled for the first time.
Nodal downstaging to ypN0 after neoadjuvant chemotherapy positively impacts on survival of cT4N+ GC/GEJ patients
Authors: Wu Liucheng , Xing Zhaoqiong , Huang Mingwei , Yu Hongping , Qin Yuzhou , Jin Qinwen , Zhou Zihan , Chen Jiansi 
Published: August 2022

AbstractBackgroundThe prognostic value of histomorphologic regression in primary gastric and gastroesophageal cancers (GC/GEJ) has been previously established, however, the impact of lymph node (LN) regression on survival still remains unclear.MethodsA prospectively maintained database was reviewed to identify cT4N+ gastric and gastroesophageal cancers (GC/GEJ) after NAC (neoadjuvant chemotherapy). Patients were categorized into two groups based on LN status: cN+/ypN0 (downstaged N0) and cN+/ypN+ (persistent N+), long‐term survival were analyzed using Kaplan–Meier survival estimates.ResultsIn total, 125 patients with cT4N+ GC/GEJ underwent NAC followed by surgery were enrolled. A total of 39 patients (31.2%) had cN+/ypN0 (ypN0) disease, 86 patients (68.8%) had cN+/ypN+ (ypN+) disease. Prognosis in ypN+ patients was significantly worse than those in ypN0 group for 3‐ and 5‐year overall survival (OS) (p < 0.05). The 3‐year OS was 83%, 44% in ypN0 and ypN+ group, respectively. The 5‐year OS was 75%, 35% in ypN0 and ypN+ group, respectively. Multivariable analysis suggested that multivisceral resection (hazard ratio [HR] = 0.33, 95% confidence interval [CI]: 0.14–0.76, p = 0.009), and ypN+ (HR = 3.42, 95% CI: 1.15–10.13, p =0.027) were independent prognostic factors for OS.ConclusionNodal downstaging is an important hallmark representing the effectiveness of NAC for GC/GEJ, and it positively impacts on survival of these patients.
Posttraumatic cognitions and sexual assault: Understanding the role of cognition type in posttraumatic stress symptoms and problematic alcohol use
Authors: Lehinger Elizabeth , Bedard‐Gilligan Michele , Holloway Ash , Kaysen Debra 
Published: August 2022

AbstractIdentifying potential mechanisms underlying the association between posttraumatic stress symptoms (PTSS) and problematic alcohol use is an important target among college women who have experienced sexual assault. This study examined the role of posttraumatic cognitions in this association among college women (N = 530) who experienced either an alcohol‐involved assault or non–alcohol‐involved assault, using baseline assessment data from a larger study examining cognitive and emotional risk factors for problem drinking. Conditional path analysis was used to examine the indirect effects of posttraumatic cognitions on the association between PTSS and alcohol use consequences, with assault type as a moderator. The findings revealed a significant indirect path from PTSS to alcohol use consequences through posttraumatic cognitions, B = 0.21, SE = 0.04, p < .001, 95% CI [0.13, 0.29], β = .16, R2 = .32. Exploratory analyses revealed a significant conditional indirect effect through self‐blame cognitions, R2 = .31, whereby the indirect effect of self‐blame on the association between posttraumatic stress and alcohol consequences was present among participants who experienced alcohol‐involved assault, B = 0.10, SE = 0.03, p < .001, 95% CI [0.06, 0.16], β = .07, but not among those who experienced a non–alcohol‐involved assault, B = 0.03, SE = 0.03, p = 0.32, 95% CI [−0.02, 0.08], β = .02. Posttraumatic cognitions are a potential mechanism underlying the link between posttraumatic stress and alcohol consequences. Addressing posttraumatic cognitions, particularly those related to self‐blame, may be an important target for interventions promoting healthy recovery following alcohol‐involved assault.
Shear Wave Elastography for Detecting Calf Muscle Stiffness: An Effective Tool for Assessing Sarcopenia
Authors: Wang Zecheng , Lyu Guorong , Zhong Huohu , Yan Lisheng , Xu Zhenhong 
Published: August 2022

ObjectivesTo explore the feasibility of shear wave elastography for evaluating sarcopenia.MethodsThe shear wave velocities (SWV) of the tibialis anterior, medial gastrocnemius, and soleus were measured in 130 subjects in the Second Affiliated Hospital of Fujian Medical University from January 2021 to June 2022. Consistency was evaluated in 20 cases using the intraclass correlation coefficient. According to the 2019 Asian Working Group for Sarcopenia（AWGS） diagnostic criteria, the patients were divided into a healthy and a sarcopenia group. The differences in SWV between the two groups were compared, and their correlation between calf muscles and muscle mass, grip strength, and pace were analyzed. The diagnostic cutoff value of calf muscle SWV for sarcopenia was obtained using receiver operating characteristic (ROC) curves, and the diagnostic efficacy of different ROC curves was compared.ResultsThe SWV inter‐group and intra‐group correlation coefficients of the three lower limbs muscles were all greater than 0.85. Moreover, the corresponding SWV in the sarcopenia group were significantly smaller than those in the healthy control group (P < .05). Further, SWV were positively correlated with the appendicular skeletal muscle mass index (ASMI), grip strength, and gait speed. Finally, the SWV of the anterior tibialis and medial gastrocnemius muscles were 3.02 and 2.26 m/s, respectively, and their diagnostic efficacy for sarcopenia did not differ significantly (Z = 0.190, P = .8497).ConclusionSWE can be used to detect the hardness of the anterior tibialis and medial gastrocnemius, calculate their muscle mass as an effective tool to evaluate sarcopenia.
Co‐occurrence of browning and oligotrophication in a boreal stream network
Authors: Mosquera Virginia , Hasselquist Eliza Maher , Sponseller Ryan A. , Laudon Hjalmar 
Published: August 2022

AbstractThe relative supply of carbon (C), nitrogen (N), and phosphorus (P) to freshwater ecosystems is of fundamental importance to aquatic productivity, nutrient cycling, and food web dynamics. In northern landscapes, ongoing climate change, as well as legacies from atmospheric deposition, have the potential to drive changes in how these elements are recycled on land and exported to streams. While it is well established that dissolved organic carbon (DOC) concentrations have increased in many high latitude streams, the simultaneous trends for N and P and the ratios among these resources, are not well documented. We used data from 13 sites in a boreal stream network to analyze decadal‐scale changes in dissolved inorganic N (DIN), dissolved organic N (DON), and dissolved inorganic P (DIP) concentrations and partition these trends seasonally. We observed widespread declines for DIP and DIN in streams, regardless of catchment characteristics. DIN decline was strongest during the growing season, and together with increases in DOC/DON at several sites, suggests increasing N retention by plants and soil microbes across this landscape. By contrast, declines for DIP occurred primarily during late autumn and winter, indicating that key biogeochemical changes are also occurring during non‐growing season. Linking these trends to increases in DOC concentration in streams revealed changes in the ratio of energy to nutrient supply for the majority of sites, becoming richer in carbon and poorer in limiting nutrients over time. Overall, our observations from this stream network point to ongoing oligotrophication, with possible consequences for aquatic ecosystems in boreal landscapes.
Monitoring and mitigating corrosion in geothermal systems
Authors: Schott Tiphaine , Liautaud Françoise 
Published: August 2022

AbstractIn terms of current needs for renewable resources, geothermal energy is one of the future solutions for heat and electricity generation. However, geothermal plants are exposed to very aggressive media (high‐temperature [HT], salt‐rich fluid, etc.), leading to extensive corrosion of the metallic parts. Should the corrosion inhibitors work at HT, their injection would be mandatory to ensure the reasonable lifetime of geothermal plants. The first part of this review concerns the degradations observed in geothermal plants, which depend on the site properties and the methods for evaluating the corrosion intensity of such systems. Autoclave experiments, although rarely used for geothermal applications, maybe the most appropriate to measure the representative corrosion rate, that is, under use temperature and pressure conditions. In the second part, clues to evaluate the performance and mechanism of corrosion inhibitors are mentioned, and molecules already used to protect steel are reported. However, this review also highlights the lack of data on HT inhibitors, especially for geothermal applications, where the efficiency of a given molecule is strongly related to the real medium. Thus, the protection of new geothermal plants where HT is reached requires the search for products that are stable and efficient under such conditions.
A 1 THz Schottky transceiver front‐end based on 5 μm GaAs monolithic membrane
Authors: He Yue , Li Li , Liu Ge , Tian Yaoling , Zhou Ren , Su Wei 
Published: August 2022

AbstractA Schottky diode‐based 1 THz Schottky transceiver front end is designed, fabricated, and measured. The terahertz mixer and tripler are fabricated with a 5 μm‐thick GaAs monolithic Schottky technology. Compact passive filter and matching network are designed to reduce the loss of transmission route. At 300 K ambient temperature, the measured minimum double‐side band noise temperature and conversion loss of 1 THz subharmonic mixer are <5000 K and 13 dB, respectively. At self‐developed available pump source, the measured maximum output power of 1 THz monolithic tripler is over 70 μW and the average output power from 960 to 1030 GHz is 35 μW. The accomplished 1 THz monolithic circuits have proved the feasibility of the proposed design process, which have certain reference value for higher frequency solid‐state Schottky‐based circuit.
A novel lightweight tubular receiver for drone wireless charging system
Authors: Cao Pengcheng , Lu Yong , Lu Changbo , Wu Shuai , Cai Chunwei 
Published: August 2022

AbstractIn the research of drone wireless charging, the lightweight design of the wireless charging device has a large impact on the overall performance of the drone. To realize the lightweight, the tubular coil, which caused by high‐frequency excitation to produce skin effect in the conductor becomes a way to optimize the weight of the receiver coil. This paper proposes an aluminum tube with a thin copper layer plated on the surface as a drone receiver coil and landing gear. This solution can not only replace the original bracket but also be lightweight and obtain high coupling coefficient. Experiments show that this novel receiver can receive power up to 30 W at 250 kHz excitation source with 78% average transmission efficiency and has good antimisalignment ability. This new tubular coupler is more suitable for the demand of lightweight wireless charging for drones.
MicroRNA21 inhibition affects porcine oocyte maturation and alters protein expression critical for metabolic pathway function
Authors: Li Yunsheng , Adur Malavika K. , Lonergan Steven M. , Keating Aileen F. , Ross Jason W. 
Published: August 2022

AbstractMicroRNA21 (MIR21) abundance in porcine oocytes and cumulus cells increases during in vitro maturation. The mechanism by which MIR21 regulates oocyte maturation and the effect on the developmental competence of subsequent embryos remains unclear. The objective of this study was to assess the function of MIR21 during porcine oocyte maturation and its effect on embryonic development. Treatment with peptide nucleic acid MIR21 inhibitor (MIR21‐PNA), designed to specifically bind to and prevent MIR21 activity during in vitro oocyte maturation, decreased cumulus cell expansion, and the oocyte ability to achieve metaphase II maturation stage when compared to control groups. Following parthenogenetic activation, the cleavage rate at 48 h in the MIR21‐PNA group was decreased (p ≤ 0.03) relative to the control groups. Additionally, liquid chromatography‐mass spectrometry (LC‐MS/MS) of oocyte and cumulus cell total protein following MIR21‐PNA treatment during in vitro maturation identified changes in signaling pathways with primary involvement of glucose metabolism (GM) pathways. Furthermore, there was no difference (p = 0.21) in oocyte maturation of control and MIR21‐PNA treated oocytes when cultured in pyruvate lacking medium. Finally, MIR21‐PNA treatment decreased (p = 0.04) glutathione and increased (p = 0.07) reactive oxygen species production in the oocyte. These data suggest that MIR21 influences porcine oocyte maturation by regulating GM pathways in the cumulus–oocyte complex.
Mechanical, absorption, and swelling properties of jute/kenaf/banana reinforced epoxy hybrid composites: Influence of various stacking sequences
Authors: Thiagamani Senthil Muthu Kumar , Pulikkalparambil Harikrishnan , Siengchin Suchart , Ilyas Rushdan Ahmad , Krishnasamy Senthilkumar , Muthukumar Chandrasekar , Radzi A. M. , Rangappa Sanjay Mavinkere 
Published: August 2022

AbstractThe effect of jute, kenaf, and banana fiber reinforced epoxy hybrid composites with different stacking sequences were fabricated by compression molding techniques. The pure epoxy, pure jute, pure kenaf, pure banana composites are also fabricated for comparison purposes. Tensile, flexural, inter‐laminar shear strengths, and hardness properties of the fabricated composites were investigated. Physical parameters like density, water absorption, and thickness swelling were also examined. From mechanical properties, the results are evident that when compared to hybrid composites pure banana composites have the highest tensile, flexural, interlaminar shear strength and shore D hardness value of 41, 67, 18, and 86 MPa respectively. Also, pure banana composites have better water absorption and thickness swelling percentage of 4% and 1.6%. However, KBJJBK hybrid composites exhibit a maximum tensile strength of 34 MPa, flexural strength of 54 MPa. Further BJKKJB hybrid composites possess the highest hardness value of 87, intralaminar shear strength of 17 MPa and lowest water absorption of 8% and thickness swelling percentage of 2%. Certain pure and hybrid configuration have enhanced mechanical strength, stiffness, and lower water absorption and thickness swelling properties, indicating that they are suitable for automotive structural applications.