bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prevalence and possible factors of cognitive frailty in the elderly with hypertension and diabetes
Authors: Lu Shourong , Xu Qiao , Yu Jie , Yang Ying , Wang Zhuo , Zhang Bingshan , Wang Shuqiang , Chen Xiaorong , Zhang Yunyun , Zhu Xiaowei , Hong Kan 
Published: November 2022

BackgroundCognitive frailty is the coexistence of physical frailty and mild cognitive impairment. Research shows that cognitive frailty is related to an increased risk of hospitalization, mortality, disability, and dementia. Diabetes and hypertension are common risk factors for physical frailty and cognitive impairment. However, the factors influencing cognitive frailty in the elderly with hypertension and diabetes are still unclear. This study aimed to investigate the possible factors influencing cognitive frailty in the elderly with hypertension and diabetes.MethodsA cross-sectional study was conducted. We evaluated people over 60 years with hypertension and diabetes who underwent physical examination in Wuxi Xin'an Community Health Service Center. Frail scale, Montreal Cognitive Assessment-Basic and clinical dementia rating were used to assess cognitive frailty. We collected demographic characteristics, hypertension and diabetes-related laboratory indicators of the participants. We also used various scales to assess the overall health status of the elderly.ResultsApproximately 20.8% of the participants were determined to have cognitive frailty in elderly adults with hypertension and diabetes. These participants were older, had a lower monthly income, and included a higher proportion of peasants. They also had a higher level of depression (p = 0.037), higher risk of falls (p = 0.000), higher risk of malnutrition (p = 0.002), poorer ability to perform activities of daily living (ADL) (p = 0.000), and less social support (p = 0.030). Multivariate regression analysis was used to further assess the factors for cognitive frailty. After adjusting for possible confounders, age and ADL score emerged as risk factors, whereas high monthly income decreased the risk of cognitive frailty.ConclusionCognitive frailty is correlated with age, income, and ability to perform daily living activities in the elderly with diabetes and hypertension. Closer attention to the elderly who have low income and poor self-care ability may play an important role in the early prevention of cognitive frailty and even dementia.
Prognostic value of a left atrioventricular coupling index in pre- and post-menopausal women from the Multi-Ethnic Study of Atherosclerosis
Authors: Pezel Théo , Michos Erin D. , Varadarajan Vinithra , Shabani Mahsima , Venkatesh Bharath Ambale , Vaidya Dhananjay , Kato Yoko , De Vasconcellos Henrique Doria , Heckbert Susan R. , Wu Colin O. , Post Wendy S. , Bluemke David A. , Allison Matthew A. , Henry Patrick , Lima Joao A. C. 
Published: November 2022

BackgroundSex hormones associated with both the left atrial (LA) and left ventricular (LV) structures in women, but the association of menopause status with left atrioventricular coupling is not established.AimTo assess the prognostic value of a left atrioventricular coupling index (LACI) in peri-menopausal women without a history of cardiovascular disease (CVD).Materials and methodsIn all women participating in MESA study with baseline cardiovascular MRI, the LACI was measured as the ratio of the LA end-diastolic volume to the LV end-diastolic volume. Cox models were used to assess the association between the LACI and the outcomes of atrial fibrillation (AF), heart failure (HF), coronary heart disease (CHD) death, and hard CVD.ResultsAmong the 2,087 women participants (61 ± 10 years), 485 cardiovascular events occurred (mean follow-up: 13.2 ± 3.3 years). A higher LACI was independently associated with AF (HR 1.70; 95%CI [1.51–1.90]), HF (HR 1.62; [1.33–1.97]), CHD death (HR 1.36; [1.10–1.68]), and hard CVD (HR 1.30; [1.13–1.51], all p &lt; 0.001). Adjusted models with the LACI showed significant improvement in model discrimination and reclassification when compared to traditional models to predict: incident AF (C-statistic: 0.82 vs. 0.79; NRI = 0.325; IDI = 0.036), HF (C-statistic: 0.84 vs. 0.81; NRI = 0.571; IDI = 0.023), CHD death (C-statistic: 0.87 vs. 0.85; NRI = 0.506; IDI = 0.012), hard CVD (C-statistic: 0.78 vs. 0.76; NRI = 0.229; IDI = 0.012). The prognostic value of the LACI had a better discrimination and reclassification than individual LA or LV parameters.ConclusionIn a multi-ethnic population of pre- and post-menopausal women, the LACI is an independent predictor of HF, AF, CHD death, and hard CVD.Clinical trial registration[https://clinicaltrials.gov/], identifier [NCT00005487].
Variable element enrichment sources and contributions to volcanic rocks along the Lesser Antilles Island Arc
Authors: Atlas Zachary D. , Germa Aurélie , Boss Brenna , Meireles Osvaldo , Ward Ami , Ryan Jeffrey G. 
Published: November 2022

Understanding relationships between different components involved in subduction-related recycling of sediment at arc volcanic systems has long been a focus of study. It is generally understood that volcanic arc lavas incorporate materials from the down-going slab including fluids, fluid mobile elements (FME), and fluid modified large ion lithophile elements (LILE), largely derived from subducted sediments and serpentinized ultramafic rocks. Past studies have presumed bulk sediment contributions rather than addressing localized variations in sediment composition. We examine trace element variability along the Lesser Antilles Island Arc (LAIA) and show that sediment inputs via fluid transfer to the mantle wedge are necessary to explain high B (up to 50 ppm), high B/La ratios, and higher As, Cs, Rb in the central LAIA. In contrast, the northern portion of LAIA is enriched in Ba, Sr and U/Th, with low FME. Grenada has low FME abundances, low Ba/La, but higher Sm/La. Our results suggest that modification of LAIA mantle source by fluid addition is important for the central islands but find that sediment enrichment is more likely in the northern section of the LAIA. Li/Yb ratios suggest the Grenada signature is chemically more comparable to sediment from DSDP Site 144 (Demerara Rise), while Martinique magmas in the central LAIA are affiliated to sediments from Site 543 (offshore Dominica). Unexpectedly, the northern portion of LAIA is not directly relatable to Site 543 sediments but instead trends back toward a sediment source similar in composition to Site 144 but with lower B, lower La/Sm and higher Ba. Binary mixing models suggest the northern islands are likely influenced by small amounts of sediment melt similar to average Site 144 sediments, but with Ba concentrations ranging from 1,250 to 1,500 ppm. Trace element ratios then likely result from different levels of contribution from sediment packages both spatially and temporally along the arc, with some variation evident among samples from the same island. We suggest that the process of recycling subducted sediment along the arc is variable along the length of the LAIA, wherein the trace element relationships are likely strongly influenced by the types of sediment being subducted along strike.
The association between metabolic parameters and evening chronotype and social jetlag in non-shift workers: A meta-analysis
Authors: Zhang Rui , Cai Xiaoling , Lin Chu , Yang Wenjia , Lv Fang , Wu Jing , Ji Linong 
Published: November 2022

AimsThe aim of the study was to evaluate the association between evening chronotype and social jetlag (SJL) with obesity, blood glucose and lipid levels in non-shift working adults.MethodsThe databases of MEDLINE, EMBASE and Cochrane Reviews were searched for studies analyzing the metabolic parameters among groups of different chronotypes or SJL until Feb 2022. Weighted mean difference (WMD) and 95% confidence intervals (CI) were used to analyze the association between these parameters and chronotypes or SJL.ResultsA total of 27 studies were included in this meta-analysis. Compared with morning chronotype, the participants with evening chronotype had higher body mass index (BMI) (WMD= 0.44 kg/m2, 95%CI, 0.30 to 0.57 kg/m2, p&lt;0.001), higher fasting blood glucose level (WMD= 5.83mg/dl, 95%CI, 3.27to 8.38 mg/dl, p&lt;0.001), higher total cholesterol level (WMD= 6.63mg/dl, 95%CI, 0.69 to 12.56 mg/dl, p=0.03), and lower high density lipoprotein cholesterol (HDL-C) level (WMD= -1.80mg/dl, 95%CI, -2.30 to -1.31 mg/dl, p&lt;0.001). Compared with the participants with small SJL, the participants with large SJL had larger waist circumference (WMD= 0.80cm, 95%CI, 0.77 to 0.83cm, p&lt;0.001).ConclusionsEvening chronotype and SJL were associated with obesity and unfavorable metabolic parameters of glucose and lipid metabolism.Systematic Review Registrationhttps://www.crd.york.ac.uk/PROSPERO/, identifier CRD42022303401.
Labor induction information leaflets—Do women receive evidence-based information about the benefits and harms of labor induction?
Authors: von Dadelszen Peter , Tohill Susan , Wade Julie , Hutcheon Jennifer A. , Scott Janet , Green Marcus , Thornton James G. , Magee Laura A. ,   the WILL Pilot Trial Study Group
Published: November 2022

ObjectivesTo determine the extent to which a sample of NHS labor induction leaflets reflects evidence on labor induction.SettingAudit of labor induction patient information leaflets—local from WILL trial (When to Induce Labor to Limit risk in pregnancy hypertension) internal pilot sites or national-level available online.MethodsDescriptive analysis [n = 21 leaflets, 19 (one shared) in 20 WILL internal pilot sites and 2 NHS online] according to NHS “Protocol on the Production of Patient Information” criteria: general information (including indications), why and how induction is offered (including success and alternatives), and potential benefits and harms.ResultsAll leaflets described an induction indication. Most leaflets (n = 18) mentioned induction location and 16 the potential for delays due to delivery suite workloads and competing clinical priorities. While 19 leaflets discussed membrane sweeping (17 as an induction alternative), only 4 leaflets mentioned balloon catheter as another mechanical method. Induction success (onset of active labor) was presented by a minority of leaflets (n = 7, 33%), as “frequent” or in the “majority”, with “rare” or “occasional” failures. Benefits, harms and outcomes following induction were not compared with expectant care, but rather with spontaneous labor, such as for pain (n = 14, with nine stating more pain with induction). Potential benefits of induction were seldom described [n = 7; including avoiding stillbirth (n = 4)], but deemed to be likely. No leaflet stated vaginal birth was more likely following induction, but most stated Cesarean was not increased (n = 12); one leaflet stated that Cesarean risks were increased following induction. Women's satisfaction was rarely presented (n = 2).ConclusionInformation provided to pregnant women regarding labor induction could be improved to better reflect women's choice between induction and expectant care, and the evidence upon which treatment recommendations are based. A multiple stakeholder-involved and evidence-informed process to update guidance is required.
Identification of a claudin-low subtype in clear cell renal cell carcinoma with implications for the evaluation of clinical outcomes and treatment efficacy
Authors: Zhang Cuijian , Li Yifan , Qian Jinqin , Zhu Zhenpeng , Huang Cong , He Zhisong , Zhou Liqun , Gong Yanqing 
Published: November 2022

BackgroundIn bladder and breast cancer, the claudin-low subtype is widely identified, revealing a distinct tumor microenvironment (TME) and immunological feature. Although we have previously identified individual claudin members as prognostic biomarkers in clear cell renal cell carcinoma (ccRCC), the existence of an intrinsic claudin-low subtype and its interplay with TME and clinical outcomes remains unclear.MethodsTranscriptomic and clinical data from The Cancer Genome Atlas (TCGA)- kidney clear cell carcinoma (KIRC) cohort and E-MTAB-1980 were derived as the training and validation cohorts, respectively. In addition, GSE40435, GSE53757, International Cancer Genome Consortium (ICGC) datasets, and RNA-sequencing data from local ccRCC patients were utilized as validation cohorts for claudin clustering based on silhouette scores. Using weighted correlation network analysis (WGCNA) and multiple machine learning algorithms, including least absolute shrinkage and selection operator (LASSO), CoxBoost, and random forest, we constructed a claudin-TME related (CTR) risk signature. Furthermore, the CTR associated genomic characteristics, immunity, and treatment sensitivity were evaluated.ResultsA claudin-low phenotype was identified and associated with an inferior survival and distinct TME and cancer immunity characteristics. Based on its interaction with TME, a risk signature was developed with robust prognostic prediction accuracy. Moreover, we found its association with a claudin-low, stem-like phenotype and advanced clinicopathological features. Intriguingly, it was also effective in kidney chromophobe and renal papillary cell carcinoma. The high CTR group exhibited genomic characteristics similar to those of claudin-low phenotype, including increased chromosomal instability (such as deletions at 9p) and risk genomic alterations (especially BAP1 and SETD2). In addition, a higher abundance of CD8 T cells and overexpression of immune checkpoints, such as LAG3, CTLA4 and PDCD1, were identified in the high CTR group. Notably, ccRCC patients with high CTR were potentially more sensitive to immune checkpoint inhibitors; their counterparts could have more clinical benefits when treated with antiangiogenic drugs, mTOR, or HIF inhibitors.ConclusionWe comprehensively evaluated the expression features of claudin genes and identified a claudin-low phenotype in ccRCC. In addition, its related signature could robustly predict the prognosis and provide guide for personalizing management strategies.
Integrated analysis of multiple microarray studies to establish differential diagnostic models of Crohn’s disease and ulcerative colitis based on a metalloproteinase-associated module
Authors: Deng Jiang , Zhao Ning , Lv Li-ping , Ma Ping , Zhang Yang-yang , Xu Jin-bo , Zhou Xi-peng , Chen Zi-an , Zhang Yan-yu 
Published: November 2022

BackgroundThe ulcerative colitis (UC) and Crohn’s disease (CD) subtypes of inflammatory bowel disease (IBD) are autoimmune diseases influenced by multiple complex factors. The clinical treatment strategies for UC and CD often differ, indicating the importance of improving their discrimination.MethodsTwo methods, robust rank aggregation (RRA) analysis and merging and intersection, were applied to integrate data from multiple IBD cohorts, and the identified differentially expressed genes (DEGs) were used to establish a protein−protein interaction (PPI) network. Molecular complex detection (MCODE) was used to identify important gene sets. Two differential diagnostic models to distinguish CD and UC were establishedviaa least absolute shrinkage and selection operator (LASSO) logistic regression, and model evaluation was performed in both the training and testing groups, including receiver operating characteristic (ROC) curves, calibration plots and decision curve analysis (DCA). The potential value of MMP-associated genes was further verified using different IBD cohorts and clinical samples.ResultsFour datasets (GSE75214, GSE10616, GSE36807, and GSE9686) were included in the analysis. Both data integration methods indicated that the activation of the MMP-associated module was significantly elevated in UC. Two LASSO models based on continuous variable (Model_1) and binary variable (Model_2) MMP-associated genes were established to discriminate CD and UC. The results showed that Model_1 exhibited good discrimination in the training and testing groups. The calibration analysis and DCA showed that Model_1 exhibited good performance in the training group but failed in the testing group. Model_2 exhibited good discrimination, calibration and DCA results in the training and testing groups and exhibited greater diagnostic value. The effects of Model_1 and Model_2 were further verified in a new IBD cohort of GSE179285. The MMP genes exhibited high value as biomarkers for the discrimination of IBD patients using published cohort and immunohistochemistry (IHC) staining data. The MMP-associated gene levels were statistically significantly positively correlated with the levels of the differentially expressed cell types, indicating their potential value in differential diagnosis. The single-cell analysis confirmed that the expression of ANXA1 in UC was higher than that in CD.ConclusionMMP-associated modules are the main differential gene sets between CD and UC. The established Model_2 overcomes batch differences and has good clinical applicability. Subsequent in-depth research investigating how MMPs are involved in the development of different IBD subtypes is necessary.
The role of Angiogenesis and remodeling (AR) associated signature for predicting prognosis and clinical outcome of immunotherapy in pan-cancer
Authors: Sun Xiaojiao , Zhang Zhuo , Wang Zhiqi , Xie Ran , Yi Chuxiao , Liu Huiyu , Chi Xiaowei , Li Tiancheng , Liu Haitao , Han Yi , Pang Xiaocong , Cui Yimin , Liu Zhenming 
Published: November 2022

BackgroundAngiogenesis and remodeling (AR) is necessary for the growth and metastasis of cancers. Although AR related genes involved in this process are reported, the correlation between AR and clinical outcome, immune cell infiltration, and immunotherapy is still unknown in diverse cancers. This study aimed to investigate the role of AR in the tumor immune microenvironment (TIME) in pan-cancer, and explore its values in prognostic prediction and therapeutic responses.MethodsFirstly, AR genes (including angiogenesis genes and blood vessel remodeling genes) are collected from MsigDB database. The differential expression, and prognostic value of AR genes were studied in 33 tumor types based on TCGA and GTEx data. The AR score of each sample was calculated using the “ssGSEA” function of R package “GSVA” in pan-cancer. The correlation of the AR score with TIME index, such as the amount of stromal and immune components and the immune cell infiltration, was evaluated via integrating multiple computational methods. And we also utilized IMvigor210 and GSE78220 data to explore the prediction value of the AR score on the immunotherapy response.ResultsSignificant differences in AR gene expression between tumors and adjacent normal tissues were found in most cancer types. The AR score varied depending on the types of tumors, and high score was related to worse survival in various tumors, such as pancreatic and stomach adenocarcinoma and so on. Moreover, the AR score was further explored to be positively correlated with proportions and pathways of immune and stromal in TIME. And the AR score was positively correlated with immunosuppressive cells, including TAMs and iTregs, while negatively with CD8+ T cells. Further analysis revealed that patients with high AR had worse therapy efficacy and survival status in bladder cancer and melanomas.ConclusionsOur systematic analysis revealed that AR is closely associated TIME, and prognosis, and clinical characteristics in multiple cancers. Targeting AR genes may activate immune microenvironment and increase the efficacy of immunotherapy.
Water quality negatively impacts coral occurrence in eutrophic nearshore environments of the Florida Keys
Authors: Thanopoulou Zoi , Patus Jacob , Sealey Kathleen Sullivan 
Published: November 2022

IntroductionCoral species are negatively impacted by anthropogenic stressors worldwide. Nearshore coastal ecosystems provide an excellent study system for the investigation of the impacts of local land-based stressors such as nutrients on coral assemblages due to their proximity to land based sources of pollution. The nearshore environs of the Florida Keys are an intensively developed and intensively managed system; Florida Keys waters have been characterized by chronic eutrophication since 1999. Benthic communities are known to change or “shift” under chronic eutrophication.ObjectivesThis research examines the patterns of occurrence in stony corals correlating to detailed nearshore water quality measurements. The questions addressed are a) What are the coral assemblages within 500 meters of the shoreline, and which species are resilient to these environs? b) How does water quality impact coral occurrence?MethodsThis study examined the immediate nearshore (0-500m) areas of 13 sites using a randomized blocked experimental design for both water quality and benthic sampling. Water quality parameters measured included chlorophyll-a, nitrates + nitrites (NOx), total nitrogen, total Kjeldahl nitrogen, total phosphorus, Salinity, pH, temperature, and dissolved oxygen. Benthic surveys documented stony coral occurrence using belt transects with point intercept measurements.ResultsStony coral species occurrence was limited at most of the study sites. Siderastrea radians and Porites divaricata were the two common species that appear to have a higher tolerance to eutrophic conditions under these shallow water conditions. Of the 13 study sites, 2 sites had no coral species occurring; this analysis was based on the comparison between sites with and without stony coral species. Water column Chlorophyll-a, pH, dissolved oxygen saturation, temperature, NOx, N:P ratio, total nitrogen and total phosphorus were found to be significantly different between the sites with and without corals. Further multivariate analysis showed a clear clustering of the two groups.ConclusionThe low overall diversity and the higher occurrences of stress tolerant species provide evidence of the effects of coastal eutrophication on the coastal Florida Keys ecosystem. Our data suggest that more conservative water quality thresholds should be posed to improve nearshore biodiversity and ecological functioning of coastal systems.
Ultra high performance concrete and C-FRP tension Re-bars: A unique combinations of materials for slabs subjected to low-velocity drop impact loading
Authors: Anas S. M. , Alam Mehtab , Isleem Haytham F. , Najm Hadee Mohammed , Sabri Mohanad Muayad Sabri 
Published: November 2022

In this research work, different combinations of normal strength concrete (NSC), ultra-high-performance concrete (UHPC), and steel fiber-reinforced UHPC (SFR-UHPC) concrete with re-bars of conventional steel and of carbon fiber-reinforced polymer (C-FRP) are used in a two-way square slab of size 1000mm x 1000mm x 75mm subjected to 2500 mm free-fall impact loading. Experimental arrangement consisting of 105 kg dropping weight with the circular flat impacting face of 40 mm diameter used for carrying out impact test is modeled using a high-fidelity physics-based finite element computer code, ABAQUS/Explicit-v.6.15. After validating the experimental results of the NSC slab with steel bars, analyses are extended by replacing NSC and steel bars with UHPC/SFR-UHPC and C-FRP bars, respectively, under the same dropping weight. Only the remote face (tension face) of the slabs is provided with the re-bars. Widely employed and available with the ABAQUS, the Concrete Damage Plasticity model with strain-rate effects has been entrusted for simulating the concrete plastic response. Re-bars of steel are idealized with the Johnson-Cook plasticity damage model. C-FRP re-bars are defined with the classical plasticity model following the elastic-plastic constitutive laws. The impact responses of the slabs consisting of NSC/UHPC/SFR-UHPC concrete with re-bars of steel, and C-FRP combinations considered are discussed and compared. Slabs made of UHPC/SFR-UHPC concrete with the C-FRP re-bars are found to offer a promising combination of materials to withstand low-velocity impact load with little damage and extraordinary impact performance.