bluuebunny/crossref_metadata_2025_split huggingface dataset:
Autistic-like behavioral effects of prenatal stress in juvenile Fmr1 mice: the relevance of sex differences and gene-environment interactions
Authors: Pietropaolo Susanna , Petroni Valeria , Subashi Enejda , Premoli Marika , Wöhr Markus , Crusio Wim E , Lemaire Valerie 
Published: February 2022

Abstract
Fragile X Syndrome (FXS) is the most common heritable form of mental retardation and the main monogenic cause of autism spectrum disorder (ASD). FXS is due to a mutation in the X-linked FMR1 gene and is characterized by motor, cognitive and social alterations, mostly overlapping with ASD behavioral phenotypes. The severity of these symptoms and their timing may be exacerbated and/or advanced by environmental adversity interacting with the genetic mutation. We therefore tested the effects of the prenatal exposure to unpredictable chronic stress on the behavioral phenotype of juveniles of both sexes in the Fmr1 knock-out (KO) mouse model of FXS. Mice underwent behavioral tests at 7–8 weeks of age, that is, when most of the relevant behavioral alterations are absent or mild in Fmr1-KOs. Stress induced the early appearance of cognitive deficits in KO male mice, without exacerbating the behavioral phenotype of mutant females. In males stress also altered social interaction and communication, but mostly in WT mice, while in females it induced effects on locomotion and communication in mice of both genotypes. Our data therefore highlight the sex-dependent relevance of early environmental stressors to interact with genetic factors to influence the appearance of selected FXS- and ASD-like phenotypes.
Microscopic structure of three-dimensional charge order in kagome superconductor AV3Sb5 and its tunability
Authors: Kang Mingu , Fang Shiang , Yoo Jonggyu , Ortiz Brenden , Oey Yuzki , Ryu Sae Hee , Kim Jimin , Jozwiak Chris , Bostwick Aaron , Rotenberg Eli , Kaxiras Efthimios , Checkelsky Joseph , Wilson Stephen , Park Jae-Hoon , Comin Riccardo 
Published: February 2022

Abstract
Correlated electronic systems are naturally susceptible to develop collective, symmetry-breaking electronic phases as observed in Cu- and Fe-based high-temperature superconductors, and twisted Moiré superlattices. The family of kagome metals AV3Sb5 (A = K, Rb, Cs) is a recently discovered, rich platform to study many of these phenomena and their interplay. In these systems, three-dimensional charge order (3D-CO) is the primary instability that sets the stage in which other ordered phases emerge, including unidirectional stripe order, orbital flux order, and superconductivity. Therefore, determining the exact nature of the 3D-CO is key to capture the broader phenomenology in AV3Sb5. Here, we use high-resolution angle-resolved photoemission spectroscopy to resolve the microscopic structure and symmetry of 3D-CO in AV3Sb5. Our approach is based on identifying an unusual splitting of kagome bands induced by 3D-CO, which provides a sensitive way to refine the spatial charge patterns in neighboring kagome planes. Notably, we found a marked dependence of the 3D-CO structure on alkali metal and doping: the 3D-CO in CsV3Sb5 is composed of kagome layers with alternating Star-of-David and Tri-Hexagonal distortions, while KV3Sb5, RbV3Sb5, and Sn-doped CsV3Sb5 realize a staggered charge pattern breaking C6 rotational symmetry. These results establish the microscopic structure of 3D-CO and its evolution with chemical composition for the first time, providing fresh insights on the origin of the cascade of exotic electronic phases in AV3Sb5.
Petrogenesis, Mineral Chemistry, and Thermobarometry of Back-Arc Basin Metabasites from the Ghoulan Area, East Azerbaijan, NW Iran
Authors: Ahmadi Zahra , Jahangiri Ahmad , Moazzen Mohssen , Oh Chang Whan 
Published: February 2022

Abstract
Amphibolites from the Ghoulan area in the East Azerbaijan province, NW Iran are metabasites containing plagioclase and hornblende as main phases also rutile and opaque minerals as accessory phases. They are spatially associated with different magmatic intrusions from the Shahjahan batholith and their relationship is sharp. These metabasites are located between three main suture zones such as Sevan-Akera suture zone in Armenia, Bitlis-Portugal suture zone in Turkey and Zagros suture zone in Iran, so their geodynamic features will help us to reconstruction paleo-geodynamic of Neotethys Ocean especially in the North West of Iranian microplate. Based on whole rock, major and trace element geochemistry of the amphibolites, they are formed from sub-alkaline basalt to andesite-basalt with tholeiitic affinity which originated from high rate partial melting (more than 10%) of mantle with spinel lherzolite to spinel-garnet lherzolite composition, they do not show any negative Ti, Nb and Ta anomaly in the different normalized spider diagrams which indicate their generating is not related to the subduction tectonic setting but they are enrichment in large ionic lithophile and LREE elements such as Rb, Sr, U, Th and Cs rather than HREE and HFSE. The geochemical composition of studied metabasites show sialic back arc basin tectonic setting. Based on plagioclase and amphibole mineral chemistry, the amphibole minerals show metamorphic and calcic features also Edenite in composition and plagioclase are andesine in composition. Thermobarometry based on amphibole composition in amphibolites shows 697-778oC temperature and 3.5- 5.5 Kbar pressure for these metabasites which can be correlate with LP-HT metamorphic facies that confirm their generation in the extensional tectonic setting. Although any age dating on these metabasites is not reported yet but due to high similarities between these metabasites and studied metabasites in the Khoy metamorphic complex (NW Iran) from petrogenesis and geochemical viewpoints, we propose that these metabasites can be correlate together and generated from a single tectonic event at a same geological time, so we propose the Paleocene –Eocene possibility time for metamorphism of studied amphibolites and closure of the back arc basin.
Identification of Potential Hub Genes and Pathways Predicting Pathogenesis in Skin Cutaneous Melanoma
Authors: Li Daishi , Ge Yi , Ke Xinchen , Pan Jie , Wang Yujie , Che Xuanlin , Guo Jia , Wang Yi , Wang Xianggui , Su Juan , Chen Xiang 
Published: February 2022

Abstract
Background: Malignant melanoma (MM) is one of the tumors with the worst prognosis among skin malignancies. However, its pathogenesis and potential therapeutic targets still need to be explored to a large extent.Methods: In the present study, we found three gene expression profiles and screened differentially expressed genes (DEGs) between melanoma and normal tissues. The DEGs were dealt with gene ontology (GO), Kyoto encyclopedia of genes and genomes (KEGG), protein–protein interaction (PPI), and survival analyses, while the connectivity map (CMap) database was used to predict candidate small molecules that may reverse the biological state of MMResults: we detected the expression of the most relevant core gene in vitro and checked the impact of the top predicted potential drug against the proliferation of MM cell lines. EXO1 were associated with unfavorable MM prognosis, ten hub genes were chose among the 77 up-regulated DEGs and 41 down-regulated DEGs, and three promising small molecule drugs for treating MM were identified. Simultaneously, we found that the highest predicted potential drug rifabutin significantly inhibits on the proliferation of melanoma cells and significantly reverses the expression of EXO1.In summary, the findings of the present study suggest that the ten hub genes and pathways identified may be closely related to MM pathogenesis.Conclusions: EXO1 overexpression could be a hopeful biomarker for revealing poor prognosis in patients with MM, while the rifabutin for the development of potential drugs to treat MM.
Structural, Optical And Photocatalytic Properties Of Cerium Doped Ba2TiMoO6 Double Perovskite
Authors: ercan filiz 
Published: February 2022

Abstract
Ce doped Ba2TiMoO6 nanomaterials with different Ce concentrations were synthesized by solid state technique. X-ray diffraction and Fourier transform infrared spectroscopy were used to analyze the purity and the crystal structure of these nanomaterials. It was determined by the XRPD method that the atomic and molecular structures of Ba2Ti1-xCexMoO6 [x=(1,3,5,7)%] compound was in the tetragonal crystal system and crystallized in the P4mm space group, and the refinement parameters were gof 1.2 and Rf 1.60. The Scanning Electron Microscopy, Transmission Electron Microscopy, and surface area analysis were used to examine the surface morphology. The UV-Vis diffuse reflectance and photoluminescence spectroscopies were used to investigate the optical properties. The study results showed the successful synthesis of pure Ba2TiMoO6 nanopowders, characterized by 8~20 nm grain size, 3.41~3.6 eV bandgap, and violet emission at 426.67 nm wavelength. To investigate the usability of the obtained nanomaterial in environmental applications, it was tested against Methyl Blue after 120 minutes of illumination. The photocatalytic efficiency was found to be approximately 16%.
The efficacy of tranexamic acid treatment with different time and doses for traumatic brain injury: a systematic review and meta-analysis
Authors: Huang Honghao , Xin Mei , Wu Xiqiang , Liu Jian , Zhang Wenxin , Yang Ke , Zhang Jinbao 
Published: February 2022

Abstract
Objective: Tranexamic acid (TXA) has been shown to play a significant role in the treatment of trauma diseases. However, its effectiveness in patients with traumatic brain injury (TBI) seems to be contradictory according to the recent publication of several meta-analyses. We aim to determine the efficacy of TXA treatment with different time and doses for TBI.Methods: PubMed, MEDLINE, EMBASE, Cochrane library and Google scholar were searched for randomized (RCT) that compared TXA and placebo in adults and adolescents (≥ 15 years of age) with TBI, up to January 31, 2022. Two authors independently abstracted data and assessed the quality of evidence. Results: Of the identified 673 studies, 13 trials involving 18,675 patients met our inclusion criteria. TXA had no effect on mortality (RR 0.99; 95% CI 0.92–1.06), adverse events (RR 0.93, 95% Cl 0.76-1.14), severe TBI (Glasgow Coma Scale score from 3 to 8) (RR 0.99, 95% Cl 0.94-1.05), unfavorable Glasgow Outcome Scale (GOS <4) (RR 0.96, 95% Cl 0.82-1.11), neurosurgical intervention (RR 1.11, 95%Cl 0.89-1.38), or new bleeding (RR 0.97, 95%Cl 0.82-1.16). TXA might reduce mean hemorrhage volume on subsequent imaging (SMD -0.35; 95% CI [-0.62, -0.08]).Conclusion: TXA at different times and doses was associated with reduced mean bleeding, but not with mortality, adverse events, neurosurgical intervention and new bleeding. We need more research data on different detection indexes and levels of TXA in patients with TBI, as compared to those not receiving TXA although the prognostic outcome for all harm outcomes was no effect, did not rule out the potential for harm. Trial registrationThe review protocol was registered in the PROSPERO International Prospective Register of Systematic Reviews (CRD42022300484).
Incidence, prognostic factors and clinical practice of Primary Pulmonary Lymphoma: A large population-based retrospective study
Authors: Hai Tao , Zou Liqun 
Published: February 2022

Abstract
Purpose: Primary pulmonary lymphoma(PPL) is a rare disease entity of pulmonary malignancies. The purpose of this study was to learn learn the incidence, treatment and survival of PPL.Methods: The incidence trend of PPL was investigated using Joinpoint regression software provided by National Cancer Institute. Cox regression analysis was performed to identify prognostic factors related to overall survival(OS) and disease-specific survival(DSS). The Kaplan-Meier method and log-rank test were used to evaluate OS and DSS.Results: A total of 1500 PPL patients were included in this study. The incidence of PPL was steadily increasing by annual percentage change(APC) of 2.7%(95%CI 2.0-3.4, P＜0.001). The median age was 66.0(19.0-99.0) years old along with more female(54.4%) patients than male. The most common subtype of PPL was marginal zone lymphoma of mucosa-associated lymphoid tissue(MALT)(41.3%) and diffuse large b-cell lymphoma(DLBCL)(29.7%), and the treatment regimens vary between these two subtype. Age, primary site, surgery, radiation, chemotherapy and laterality were identified as independent prognostic factors. Nomograms constructed for PPL-MALT and PPL-DLBCL to predict 1-, 5-, and 10-year OS and DSS. The area under curve (AUC) and calibration curves exhibit robust and accurate performance.Conclusions: Although rarely diagnosed, the incidence of PPL was steadily increasing in the past four decades. Nomograms for MALT and DLBCL in predicting 1-, 5-, 10-year OS and DSS were reliable. A diagram was drawn to describe PPL-MALT and PPL-DLBCL clinical practice.
Role of Neuroimaging in Suspected Dementia Patients: Utilization of Structural Imaging Algorithmic-Based Diagnosis in Resource Limited Settings
Authors: Ayele Biniyam A. , Guta Betesaida , Tesfaye Heera , Guta Tsega , Zebenigus Mehila , Tadesse Yonas , Zenebe Guta 
Published: February 2022

Abstract
Background
In 2050, it is estimated that the number of dementia patients in the sub Saharan Africa is expected to reach 5.05 million, an increase of 136% from the previous estimate of 2.14 million. The objectives of the present study were to assess the neuroimaging findings and associated factors in dementia suspected patients.
Method
A retrospective survey of the medical records of 121 suspected dementia patients whom presented to the Yehuleshet Specialty Clinic with subjective forgetfulness were reviewed. The study duration was between January 1, 2020 and December 31, 2021. Both descriptive and analytical statistics were used to analyze the data.
Results
The mean age was 70.4 (1SD = 10.3) years. Sixty four (52.9%) participants were age below 70. Male accounted for 57.9%. Hyperlipidemia was the commonest (38%) identified vascular risk factor followed by prevalence of hypertension (32.2%) and diabetes mellitus (22.3%). HIV infection was observed in 3.3%. Low mean serum vitamin D level (below 20ng/mL) was observed in individuals with focal & global cortical atrophy and those with white matter hyperintensity. Fifty two (43%) participants fulfilled the clinical and imaging criteria of vascular cognitive impairment (VCI). Nearly quarter of the patients had imaging evidences of focal or global cortical atrophy. Eleven (9.1%) had imaging evidences of surgical causes of dementia. the presences of comorbid hypertension, previous stroke, and Parkinsonism were independent predictors of vascular dementia.
Conclusion
The present study shows high burden of vascular cognitive impairment among individuals suspected of dementia. Furthermore, the presences of comorbid hypertension, previous stroke, and Parkinsonism were independent predictors of vascular dementia.
Exploring the correlation between changes in gut microbial community diversity and depression in human populations
Authors: Li Xin , Jing Ke , Lu Hong , Li Ke , Zhang Yaowu , chaolu Hasi 
Published: February 2022

Abstract
Background
Depression, also known as depressive disorder, is a group of psychosomatic affective disorders characterized by persistent and significantly depressed mood, delayed thinking, and cognitive impairment. The aim of this study was to explore the correlation between changes in gut microbial community diversity and depression to provide data on new strategies for the prevention and treatment of depression.
Methods
In this study, we separated participants into a group of depressed patients and a healthy control group and analyzed their gut microbiota. We analyzed the gut microbial community structure of depressed patients and healthy controls using second-generation sequencing of the bacterial 16S RNA gene. We also explored the relative abundance of important microorganisms associated with the development of depression using a bioinformatics method.
Results
There were significant differences in the gut microflora structure between patients with depression and healthy individuals. The gut flora alpha diversity index was significantly reduced in patients with depression compared to that in the healthy population. At the species level, the relative abundance of Coprococcus catus and Bacteroides barnesiae was significantly lower in the depressed group than in the control group.
Conclusion
The development of depression may be associated with a decrease in beneficial gut bacteria.
Phaeohyphomycosis in a COVID-19 Patient Caused by Neoscytalidium Dimidiatum
Authors: Dolatabadi Somayeh , Nasirharandi Sara , Pourahmad Morteza , Ahmadikia Kazem , Mokhtari Mojgan , Najafzadeh Mohammad Javad , Mohammadi Rasoul 
Published: February 2022

Abstract
We report a case of 32-years-old male with a cerebral phaeohyphomycosis post COVID-19 infection from Iran. The causative agent was identified by histopathology, routine mycological methods and confirmed by DNA sequencing of the internal transcribed spacer (ITS) region of rDNA and proved to be Neoscytalidium dimidiatum which is an opportunistic dematiaceous fungus belonging to Dothideomycetes.No apparent underlying disease was seen beside his COVID-19 complications and corticosteroid therapy. Symptoms indicative of his fungal infection appeared two weeks after his COVID-19 scenario. The brain MRI showed multi-focal CNS infection as abscess. Delayed identification of the fungus and antifungal treatment with amphotericin B may have affected the outcome, thus the patient died on day 25 post COVID-19 infection.Considering, rare incidence of infections due to N. dimidiatum, reporting this case will add to our awareness and may lead us to a timely management.
2D-metrics in routine dental radiographs correlate with bone supply of intraoral donor regions: A retrospective analysis
Authors: Brockmeyer Phillipp , Wiechens Bernhard , Sevinc Tayhan , Schliephake Henning , Hahn Wolfram 
Published: February 2022

Abstract
Background: To test the hypothesis that cephalometric parameters in two-dimensional routine dental radiographs correlate with the bone supply of intraoral donor regions. Methods: A total of 108 radiographs (36 panoramic radiographs [PRs], 36 lateral cephalometric radiographs [LCRs], and 36 cone-beam computed tomography scans [CBCT]) of 36 patients were analysed. Cephalometric parameters (PR and LCR) were correlated with the bone supply measurement in three-dimensional CBCT scans in three different intraoral donor regions (chin, mandibular retromolar region, and zygomatic alveolar crest). Results: Different mean bone volumes were measured for the chin (3.10 ± 1.11 cm³ SD), the mandibular retromolar region (1.66 ± 0.54 cm³ SD), and the zygomatic alveolar crest (0.17 ± 0.04 cm³ SD). Cephalometric parameters were significantly correlated with the bone dimensions in the chin and the mandibular retromolar region (all p-values < 0.05). Bone volume of the zygomatic alveolar crest exhibited no correlations with cephalometric parameters but significantly correlated with the mandibular retromolar bone volume (p < 0.01). No gender-specific differences were observed with respect to bone volumes in all bone harvesting regions. However, the interforaminal distance in the chin region was significantly higher in the male population (p = 0.001). Conclusion: Routine 2D radiographs can be used during the initial consultation for primary intraoral bone donor site evaluation. This is anticipated to be helpful in defining indications and justifying further diagnostic options such as three-dimensional radiological techniques.
Relationship Between Peripheral Blood Eosinophil Count and the Severity and Prognosis of Children with Duchenne Muscular Dystrophy : A New Potentially Useful Predictor?
Authors: Jiang Zhi , Liao Hongmei , Wu Liwen , Hu Wenjing , Yang Liming , Chen Bo , Ning Zeshu , Tang Jingwen , Xu Rong , Chen Mei , Guo Feng , Liu Shulei 
Published: February 2022

Abstract
Objective To investigate the effect of peripheral blood eosinophil count on the severity and prognosis of Duchenne Muscular Dystrophy（DMD). Method The clinical data of 145 patients with DMD and 150 normal healthy children in the same period were collected retrospectively. The results of the two groups were analysed and compared. Logistic regression and Cox regression analysis were used to explore the influence of eosinophils on DMD. The relationship between eosinophils and the long-term efficacy and prognosis of DMD were followed up. Result Compared with the control group, the eosinophil count of children in DMD group was slightly lower(Z=2.163,p=0.031).Eosino-phil count at visit and follow-up was slightly negatively correlated with muscle strength score to visit and follow-up, and the correlati-on coefficients were as follows: ρ=-0.245，p=0.040，ρ=-0.137，p=0.032.Eosinophils were the protective factor for high muscle strength score of visit,OR=0.007,95%CI(0.001-0.276)，p=0.008,OR=0.038,95%CI(0.002-0.752), p=0.032 after adjusting for age and other factors. Eosinophils were also the protective factor for elevated muscle stre-ngth score at follow-up visit,(OR=0.012,95%CI0.001-0.645,p=0.029), after adjusting for age and other factors (OR=0.033,95%CI0.001-0.121,p=0.039). Univariate analysis found that eosinophils affected the curative effect during follow-up visit, HR=2.739,95%CI(1.294-5.979)p=0.008. Further adjustment for age and other factors multivariate Cox regression analysis found that eosinophils affected the curative effect (HR=1.127,95% CI 1.109-1.246,p=0.020).Conclusion The eosinophil count in peripheral blood was related to the severity of DMD, and can predict the curative effect and prognosis to a certain extent. Eosinophil count may be a potentially useful predictor.
Prevalence and risk factors for kidney disease in Chinese HIV-Infected patients: A cross-sectional study
Authors: Zhao Naxin , Xiang Pan , Zeng Zhili , Liang Hongyuan , Wang Fang , Xiao Jiang , Yang Di , Chen Meiling , Gao Guiju 
Published: February 2022

Abstract
Background
Kidney disease is an important comorbidity in HIV-infected patients, and is associated with poor outcomes of these patients. However, data on kidney function in Chinese HIV-Infected patients are scarce. In this study we determined the prevalence of kidney disease in PLWH involving ART-naïve patients and ART-experienced patients in China and explored its associated risk factors.
Methods
In the cross-sectional study, we recruited hospitalized adult HIV-infected patients. Demographic characteristics, clinical information and laboratory variables were collected. Kidney disease was defined as eGFR < 60 mL/min/1.73 m2, hematuria, proteinuria, or microalbuminuria. We calculated the prevalence of kidney disease and used logistic regression to assess its associated risk factors.
Results
A total of 501 Chinese adult HIV-infected patients were enrolled, with 446 (89.0%) male and 55 (11.0%) female. Median age was 39 (IQR 30–50) years old. The prevalence of kidney disease was 19.0%. 22 (4.4%) patients had eGFR < 60 mL/min/1.73 m2, 53 (10.6%) patients had hematuria, 11 (2.2%) patients had proteinuria, 40 (8.0%) patients had microalbuminuria. Using univariate analysis, kidney disease was found to be significantly associated with older age, hypertension, diabetes mellitus, duration of HIV, ART and its duration, TDF-containing regimen, HIV viral load < 20 copies/mL, lower hemoglobin and albumin, higher UA, CRP, CHOL and TG. In the multivariate logistic regression analysis, older age (OR 1.031, 95%CI: 1.006–1.058, P = 0.016), diabetes mellitus (OR 3.699, 95%CI: 1.388–9.860, P = 0.009) and Anemia (hemoglobin OR 0.970, 95%CI: 0.954–0.986, P = 0.000) were significantly associated with kidney disease.
Conclusions
The prevalence of kidney disease in HIV-infected patients in China is high. It is very important to monitor renal function and comprehensively manage the various risk factors in these people. Especially, there is an urgent need to study antiretroviral drugs with no or less nephrotoxicity and with the ability to prevent the virus from depositing in the kidney to protect renal function of HIV-infected patients.