bluuebunny/crossref_metadata_2025_split huggingface dataset:
Manipulating Li3V2(PO4)3 cathode grains and conductivity with halloysite nanotubes and carbon layer toward durable lithium ion batteries
Authors: Dong Qi , Chen Xingyu , Jiang Ao , Zhang Xinyi , Chen Shanhua , Hao Shuai , Zhang Zhengdong , Di Yuli , Li Taishan 
Published: December 2022

AbstractAs an olivine‐based cathode with high discharge platform and theoretical capacity, Li3V2(PO4)3's (LVP's) low conductivity and excessive grain size are the important factors hindering its development in the battery field. Halloysite nanotubes (HNTs) is a natural and cheap nanotube‐like material with large specific surface area and abundant surface nucleation sites, which can cooperate with conductive carbon layer to solve the deficiency of LVP. In this paper, we design a cathode material for in‐situ growth of LVP on HNTs (LVP@HNTs) and demonstrate that it has the appropriate particle size and the excellent specific surface area in the mass ratio of LVP to HNTs is 2:1. The capacity retention rate of LVP@HNTs‐2 reached almost 100% (97.0 mAh g−1) after 100 cycles at a low rate of 0.5 C. Moreover, its specific discharge capacity is 89.3 mAh g−1 at a high rate of 20 C and its capacity retention rate is as high as 90.1% (80.5 mAh g−1) after 5,000 cycles, showing that the LVP@HNTs‐2 has marvelous rate capability and cycle stability. This study provides an innovative strategy for the development of the high‐performance cathode materials with low‐cost, excellent rate capability, and cycle stability of lithium ion batteries.
Long non‐coding RNA HOXC‐AS1 exerts its oncogenic effects in esophageal squamous cell carcinoma by interaction with IGF2BP2 to stabilize SIRT1 expression
Authors: Yang Zhengwu , Wan Junhu , Ma Liwei , Li Zhuofang , Yang Ruotong , Yang Haijun , Li Junkuo , Zhou Fuyou , Ming Liang 
Published: December 2022

AbstractBackgroundLong non‐coding RNA HOXC cluster antisense RNA 1 (HOXC‐AS1) is a novel lncRNA whose cancer‐promoting effect in gastric cancer and nasopharyngeal carcinoma has already been demonstrated. However, its functions in esophageal squamous cell carcinoma (ESCC) remains unknown. LncRNAs can interact with RNA‐binding proteins (RBPs) and affect gene expression levels through post‐transcriptional regulation. Insulin‐like growth factor 2 mRNA‐binding protein 2 (IGF2BP2) is a widely studied RBP, and sirtuin 1 also known as SIRT1 has been reported to be involved in cancer progression.MethodsEstablishment of in vivo models, HE and immunohistochemistry staining verified the oncogenic effect of HOXC‐AS1. The interaction relationship between HOXC‐AS1, IGF2BP2 and SIRT1 was verified by RNA pulldown and RNA immunoprecipitation (RIP) assay. Relative expression and stability changes of genes were detected by qPCR and actinomycin D experiments. Finally, the effect of HOXC‐AS1‐IGF2BP2‐SIRT1 axis on ESCC was verified by rescue experiments.ResultsHOXC‐AS1 is highly expressed in ESCC cells and plays oncogenic effects in vivo. qPCR showed the positive relationship between HOXC‐AS1 and SIRT1 following HOXC‐AS1 knockdown or overexpression. RNA‐pulldown, mass spectrometry and RIP assay demonstrated that IGF2BP2 is an RBP downstream of HOXC‐AS1. Then, RIP and qPCR showed that IGF2BP2 could bind to SIRT1 mRNA and knockdown IGF2BP2 resulted in decreased SIRT1 mRNA level. Finally, a series of rescue assay showed that the HOXC‐AS1‐IGF2BP2‐SIRT1 axis can affect the function of ESCC.ConclusionLncRNA HOXC‐AS1 acts as an oncogenic role in ESCC, which impacts ESCC progression by interaction with IGF2BP2 to stabilize SIRT1 expression.
Growth arrest and DNA damage‐inducible alpha regulates muscle repair and fat infiltration through ATP synthase F1 subunit alpha
Authors: You Wenjing , Liu Shiqi , Ji Jianfei , Ling Defeng , Tu Yuang , Zhou Yanbing , Chen Wentao , Valencak Teresa G. , Wang Yizhen , Shan Tizhong 
Published: December 2022

AbstractBackgroundSkeletal muscle fat infiltration is a common feature during ageing, obesity and several myopathies associated with muscular dysfunction and sarcopenia. However, the regulatory mechanisms of intramuscular adipogenesis and strategies to reduce fat infiltration in muscle remain unclear. Here, we identified the growth arrest and DNA damage‐inducible alpha (GADD45A), a stress‐inducible histone folding protein, as a critical regulator of intramuscular fat (IMAT) infiltration.MethodsTo explore the role of GADD45A on IMAT infiltration and muscle regeneration, the gain or loss function of GADD45A in intramuscular preadipocytes was performed. The adipocyte‐specific GADD45A knock‐in (KI) mice and high IMAT‐infiltrated muscle model by glycerol injection (50 μL of 50% v/v GLY) were generated. RNA‐sequencing, histological changes, gene expression, lipid metabolism, mitochondrial function and the effect of dietary factor epigallocatechin‐3‐gallate (EGCG) treatment (100 mg/kg) on IMAT infiltration were studied.ResultsThe unbiased transcriptomics data analysis indicated that GADD45A expression positively correlates with IMAT infiltration and muscle metabolic disorders in humans (correlation: young vs. aged people, Gadd45a and Cebpa, r2 = 0.20, P < 0.05) and animals (correlation: wild‐type [WT] vs. mdx mice, Gadd45a and Cebpa, r2 = 0.38, P < 0.05; NaCl vs. GLY mice, Gadd45a and Adipoq/Fabp4, r2 = 0.80/0.71, both P < 0.0001). In vitro, GADD45A overexpression promotes intramuscular preadipocyte adipogenesis, upregulating the expression of adipogenic genes (Ppara: +47%, Adipoq: +28%, P < 0.001; Cebpa: +135%, Fabp4: +16%, P < 0.01; Pparg: +66%, Leptin: +77%, P < 0.05). GADD45A knockdown robustly decreased lipid accumulation (Pparg: −57%, Adipoq: −35%, P < 0.001; Fabp4: −37%, P < 0.01; Leptin: −28%, P < 0.05). GADD45A KI mice exhibit inhibited skeletal muscle regeneration (myofibres: −40%, P < 0.01) and enhanced IMAT infiltration (adipocytes: +20%, P < 0.05). These KI mice have impaired exercise endurance and mitochondrial function. Mechanistically, GADD45A affects ATP synthase F1 subunit alpha (ATP5A1) ubiquitination degradation (ubiquitinated ATP5A1, P < 0.001) by recruiting the E3 ubiquitin ligase TRIM25, which decreases ATP synthesis (ATP production: −23%, P < 0.01) and inactivates the cAMP/PKA/LKB1 signalling pathway (cAMP: −36%, P < 0.01; decreased phospho‐PKA and phospho‐LKB1 protein content, P < 0.01). The dietary factor EGCG can protect against muscle fat infiltration (triglyceride: −64%, P < 0.05) via downregulating GADD45A (decreased GADD45A protein content, P < 0.001).ConclusionsOur findings reveal a crucial role of GADD45A in regulating muscle repair and fat infiltration and suggest that inhibition of GADD45A by EGCG might be a potential strategy to combat fat infiltration and its associated muscle dysfunction.
Removal of antimony by dissimilatory and sulfate‐reducing pathways in anaerobic packed bed bioreactors
Authors: Ramírez‐Patiño Jesús , Pérez‐Trevilla Jaime , Cervantes Francisco J. , Moreno‐Andrade Iván 
Published: December 2022

AbstractBACKGROUNDAntimony is a toxic and potentially carcinogenic metalloid widely used in industry, whose untreated wastewater could lead to water body pollution. Antimony‐reduced species tend to precipitate in the form of minerals. The biological reduction of antimonate to antimonite occurs under anaerobic conditions by two extracellular pathways: dissimilatory biological reduction and reaction with dissolved H2S in sulfate‐reducing systems. The objective of this study was to determine antimonate removal from synthetic wastewater by dissimilatory and sulfate‐reducing pathways in anaerobic packed bed reactors.RESULTSThe average antimony removal was 28.4% and 58.8% for the dissimilatory and sulfate‐reducing processes, respectively. At the end of the experiment, X‐ray diffraction analysis demonstrated the presence of valentinite in the dissimilatory reactor, and struvite, valentinite, and kermesite in the sulfate‐reducing reactor, being a crystal form resulting from stibnite oxidation by exposure to environmental conditions. Phylogenetic analysis showed the presence of genera Geobacter and Pseudomonas, associated with the dissimilatory reduction, and a high abundance of sulfate‐reducing bacteria in the sulfate‐reducing reactor. In the dissimilatory reactor, there was a dominance of the genus Dysgonomonas, which could play a key role in the redox transformation of the metalloid.CONCLUSIONAntimony removal has been obtained in dissimilatory and sulfate‐reducing processes. Valentinite was observed in the dissimilatory reactor, and struvite, valentinite, and kermesite in the sulfate‐reducing reactor. Phylogenetic analysis showed differences between both processes, with a possible key genus acting in the antimony transformation. © 2022 The Authors. Journal of Chemical Technology and Biotechnology published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry (SCI).
An obscure cause of gastrointestinal bleeding: Recurrent duodenal variceal hemorrhage treated with intramuscular octreotide in the absence of portal hypertension
Authors: O'Neill Robert S , Wang William J , Chan Patrick , Ho Vincent , Verdon Christine , Turner Ian , Acharya Priya 
Published: December 2022

AbstractDuodenal varices (DVs) are ectopic gastrointestinal varices (ECVs) associated with portal hypertension (PH). We present the case of an 82‐year‐old woman who presented with symptomatic anemia secondary to DV hemorrhage diagnosed on oesophagogastroduodenoscopy. This lesion was treated with endoscopic adrenaline injection and clip application. The patient re‐presented on multiple occasions with bleeding recurrence localized to the duodenum, which was managed with intramuscular octreotide and oral beta‐blockade resulting in sustained remission of bleeding. This case highlights a rare cause of upper gastrointestinal hemorrhage and highlights the value of somatostatin analogues for conservative treatment of DVs.
Mechanical harvesting at dawn in a super‐high‐density table olive orchard: effect on the quality of fruits
Authors: Morales‐Sillero Ana , Jiménez María Rocío , Suárez María Paz , Rallo Pilar , Casanova Laura 
Published: December 2022

AbstractBACKGROUNDMechanical harvesting with over‐the‐row harvesters in super‐high‐density (SHD) table olive orchards increases the effectiveness of fruit removal, although bruising can limit the fruit quality. Additionally, an early harvest in periods less favourable to quality production is increasingly frequent as a result of global warming. The present study explores the impact on olive quality of harvesting at dawn when the environmental temperature is low. The study was carried out for 2 years on two cultivars with different tolerance to bruising (‘Manzanilla de Sevilla’ and ‘Manzanilla Cacereña’), grown in SHD conditions and harvested at two timepoints: dawn and morning.RESULTSFruit morphology was not modified by the moment of harvest in either of the cultivars. Fruit harvested at dawn produced less CO2 and ethylene and was less damaged externally and internally compared to fruit harvested in the morning. However, environmental conditions throughout development influenced the response because the highest values of bruising (incidence, area and volume of damaged area), total internal damage and the number of tissue ruptures increased in the year with the hottest summer, and the differences between harvest treatments were less evident.CONCLUSIONMechanical harvesting at dawn contributes to reducing the damage in olive fruit. © 2022 The Authors. Journal of The Science of Food and Agriculture published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.
Improving OutpatientFollow‐UpRates for NewIn‐HospitalConsults
Authors: Stanisce Luke , Ahmad Nadir , Solomon Donald H. , Kolia Nadeem , Garcia Lucia D. , Spalla Thomas C. , Gaughan John P. , Koshkareva Yekaterina 
Published: December 2022

Objective(s)This investigation aimed to define the rate of outpatient follow‐up after in‐hospital consultation, identify factors associated with establishing care, and evaluate an alternative scheduling process to improve outpatient adherence.MethodsTwo‐phase, prospective study at an academic, tertiary‐care institution from March 2020 to August 2022. First, all patients not previously known to our practice encountered via inpatient consult who warranted outpatient follow‐up were prospectively captured. Logistic regression analysis was used to identify demographic, disease, and practice factors predictive of follow‐up. Second, a randomized control trial was performed to validate the effects of pre‐assigning appointments prior to discharge.ResultsSix hundred subjects were included in the final study cohort; 500 in phase‐one, and 100 randomized during phase‐two. In the phase‐one cohort, 54% (n = 272) were lost to follow‐up. Multivariate analysis showed increased odds of outpatient follow‐up when appointments were pre‐assigned before discharge (odds ratio [OR]: 3.69 [95% confidence interval [CI]: 2.29–5.96],p < 0.001), the primary reason for hospitalization was ENT and consult‐related (OR: 3.29 [1.92–5.64],p < 0.001), and the diagnosis was one of Oncology (OR: 1.93 [1.02–3.69],p = 0.045) or Pediatrics (OR: 3.36 [1.41–7.98],p = 0.006) subspecialties. During phase‐two, subjects randomized for pre‐assigned appointments had higher outpatient follow‐up (82%) compared to the control group (20%) (p < 0.001).ConclusionHospital‐based consultations represent an important referral pathway for new patients. Disease characteristics may identify patients less likely to follow‐up upon discharge. Appointment scheduling protocols, including pre‐assigning appointments, are modifiable targets for improving adherence to care.Laryngoscope, 133:2540–2545, 2023
A review of lentil (Lens culinaris Medik) value chain: Postharvest handling, processing, and processed products
Authors: Oduro‐Yeboah Charlotte , Sulaiman Rabiha , Uebersax Mark A. , Dolan Kirk D. 
Published: December 2022

AbstractLentils (Lens culinaris Medik.) are grown worldwide in diverse agroecological regions with significant global production and trade. Since early 2000s, lentils production and consumption have been growing beyond its traditional areas of production and utilization, notably in USA, Canada, Australia, UK, and many European Union countries. Lentils are a rich source of protein, minerals, and many bioactive compounds. Therefore, lentil‐based products can offer a healthy food choice for all consumers, including those who are vegetarian or vegans, and/or looking for meat protein alternatives due to health and/or environmental concerns. In order to avail all the benefits that lentils offer, a quality maintenance approach is essential across value‐chain operations of postharvest handling, storage, and value‐added processing. In recent years, lentils have been used increasingly in a variety of value‐added products and cuisines in the developed countries. Different processing methods, for example, cooking, autoclaving, extrusion, baking, roasting, fermentation, and sprouting, significantly improve protein bioavailability, total digestibility, and overall nutritional and organoleptic quality. A number of traditional and innovative processing techniques also have been used to produce lentil‐based end‐products or ingredients for various food applications. Overall, lentils are well positioned as a food legume crop to cater to emerging trends among consumers, especially those looking for healthy food choices, an alternative plant‐based protein for global food security, and foods that are produced in environmentally friendly and agriculturally sustainable manner. Significant production and consumption trends for lentils clearly demonstrate enhanced value for consumers and further impact in contributions to a nutritious global food supply.
Recent Research Progress of 19F Magnetic Resonance Imaging Probes: Principle, Design, and Their Application
Authors: Mo Yongyi , Huang Chixiang , Liu Changjiang , Duan Ziwei , Liu Juan , Wu Dalin 
Published: December 2022

AbstractVisualization of biomolecules, cells, and tissues, as well as metabolic processes in vivo is significant for studying the associated biological activities. Fluorine magnetic resonance imaging (19F MRI) holds potential among various imaging technologies thanks to its negligible background signal and deep tissue penetration in vivo. To achieve detection on the targets with high resolution and accuracy, requirements of high‐performance 19F MRI probes are demanding. An ideal 19F MRI probe is thought to have, first, fluorine tags with magnetically equivalent 19F nuclei, second, high fluorine content, third, adequate fluorine nuclei mobility, as well as excellent water solubility or dispersity, but not limited to. This review summarizes the research progresses of 19F MRI probes and mainly discusses the impacts of structures on in vitro and in vivo imaging performances. Additionally, the applications of 19F MRI probes in ions sensing, molecular structures analysis, cells tracking, and in vivo diagnosis of disease lesions are also covered in this article. From authors’ perspectives, this review is able to provide inspirations for relevant researchers on designing and synthesizing advanced 19F MRI probes.
The role of technological innovation, strategy, firms performance, and firms size and their aggregate impact on organizational structure
Authors: Li Haishi , Jiang Youxue , Ashiq Anam , Salman Asma , Haseeb Mohammad , Shabbir Malik Shahzad 
Published: December 2022

AbstractThis study investigates how numerous contingencies work together to influence the organizational structure of privately held businesses in China. This study is using a cross‐section primary data set from 83 private firms listed in China. The data are gathered by face‐to‐face interviews with entrepreneurs, and six hypotheses tests are performed regarding the contingencies of organizational form. Furthermore, the empirical findings indicate that environment, strategy, size, and technology play a significant role in explaining organizational form. Finally, financial factors are important aspects of the business environment, notably in dealing with cash flow problems and in forming profit expectations.
Real‐time 3D MRI reconstruction from cine‐MRI using unsupervised network in MRI‐guided radiotherapy for liver cancer
Authors: Wei Ran , Chen Jiayun , Liang Bin , Chen Xinyuan , Men Kuo , Dai Jianrong 
Published: December 2022

AbstractPurposeRespiration has a major impact on the accuracy of radiation treatment for thorax and abdominal tumours. Instantaneous volumetric imaging could provide precise knowledge of tumour and normal organs’ three‐dimensional (3D) movement, which is the key to reducing the negative effect of breathing motion. Therefore, this study proposed a real‐time 3D MRI reconstruction method from cine‐MRI using an unsupervised network.Methods and materialsCine‐MRI and setup 3D‐MRI from eight patients with liver cancer were utilized to establish and validate the deep learning network for 3D‐MRI reconstruction. Unlike previous methods that required 4D‐MRI for network training, the proposed method utilized a reference 3D‐MRI and cine‐MRI to generate the training data. Then, a network was trained in an unsupervised manner to estimate the relationship between the cine‐MRI acquired on coronal plane and deformation vector field (DVF) that describes the patient's breathing motion. After the training process, the coronal cine‐MRI were inputted into the network, and the corresponding DVF was obtained. By wrapping the reference 3D‐MRI with the generated DVF, the 3D‐MRI could be reconstructed.ResultsThe reconstructed 3D‐MRI slices were compared with the corresponding phase‐sorted cine‐MRI using dice similarity coefficients (DSCs) of liver contours and blood vessel localization error. In all patients, the liver DSC had mean value >96.1% and standard deviation < 1.3%; the blood vessel localization error had mean value <2.6 mm, and standard deviation was <2.0 mm. Moreover, the time for 3D‐MRI reconstruction was approximately 100 ms. These results indicated that the proposed method could accurately reconstruct the 3D‐MRI in real time.ConclusionsThe proposed method could accurately reconstruct the 3D‐MRI from cine‐MRI in real time. This method has great potential in improving the accuracy of radiotherapy for moving tumours.
Preparation of highly efficient thermal insulating halloysite nanotubes/polyvinyl alcohol composite aerogel based on a simple freeze‐drying strategy
Authors: Lv Qingtao , Yang Jingfeng , Sun Xin , Tang Hui , Wang Lixin 
Published: December 2022

AbstractThe development of high‐performance energy‐saving insulation materials is significant for reducing building energy consumption and promoting carbon neutrality. Aerogels show great potential in energy‐saving insulation. However, their high preparation cost and poor mechanical properties limit their application. Here, based on a simple freeze‐drying strategy, a halloysite nanotubes (HNTs)/polyvinyl alcohol (PVA) composite aerogel is achieved via low‐cost and degradable industrial raw material. In particular, a simple process for changing the properties of HNTs/PVA composite aerogels by regulating the solid concentration. As a result, stable covalent cross‐linking and hydrogen bonding structure between HNTs and PVA, long‐range ordered pore structure with high porosity (97.6%), low density (0.12 g/cm3), and low thermal conductivity (44.333 mW/m K) endow the HNTs/PVA composite aerogel high compressive strength (3.33 MPa), lightweight, and highly efficient thermal insulation properties. This work offers an attractive material for building insulation and carbon neutral.
Effects of silane‐modified nano‐CaCO3 particles on the mechanical properties of carbon fiber/epoxy (CF/EP) composites
Authors: Durukan Seyma Nur , Beylergil Bertan , Dulgerbaki Cigdem 
Published: December 2022

AbstractIn this study, the effects of silane‐treated nano‐CaCO3 particles on the flexural, Mode‐I, Mode‐II and interlaminar shear strength (ILSS) properties of carbon fiber/epoxy composites are investigated experimentally. The surface of nano‐CaCO3 particles is treated with a silane coupling agent, namely, (3‐Glycidyloxypropyl) trimethoxysilane (GPTMS). Three‐point bending, double cantilever beam (DCB), end‐notch flexure (ENF), and short beam shear (SBS) tests are carried out on the prepared composite specimens according to the relevant ASTM requirements. The results show that with the dispersion of 5 wt% silane‐treated nano‐CaCO3 particles the flexural modulus, flexural strength, Mode‐I fracture toughness, Mode‐II fracture toughness, and ILSS values can be enhanced by 16.8%, 13.6%, 25.7%, 19.6%, and 19.8%, respectively, compared to reference composites. The storage modulus is also increased by about 15.3% with the silane‐treated nano‐CaCO3 particles. The silane‐treated nano‐CaCO3 particles had no significant effect on the glass transition temperature of the composites.