bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dynamics of ovarian maturation during the annual reproductive cycle of the endangered fish Steindachneridion parahybae (Siluriformes: Pimelodidae) in captivity
Authors: Honji Renato Massaaki , Araújo Bruno Cavalheiro , Caneppele Danilo , Nostro Fabiana Laura Lo , Moreira Renata Guimarães 
Published: April 2022

AbstractTo characterize the female reproductive biology of the endangered species Steindachneridion parahybae in captivity, the authors used the concentration of gonadal steroids and the oocyte development during the annual reproductive cycle (RC) and after artificial induced spawning (AIS) until 48 h. Three stages of gonadal maturation were identified, based on morphological and physiological features: early maturation or previtellogenic (PRV) oocyte, advanced maturation or vitellogenic (VTG) oocyte and regression (REG) or follicular atresia. They identified and characterized the following stages of germ cells: oogonia, perinucleolar and cortical alveoli, and VTG and atretic oocytes during RC. The oestradiol levels were higher in PRV than those in VTG and REG during the RC, whereas androgens showed higher levels of oestradiol in VTG than those in PRV and REG. The progestogen levels remained unchanged during the whole RC. The final oocyte maturation (FOM) was achieved after AIS and postovulatory follicles (POF) were identified. Plasma concentration of progestogens (17α,20β‐dihydroxy‐pregnen‐3‐one and 17α‐hydroxyprogesterone) increased considerably after AIS, remaining high up to 6 h after AIS, and progressively decreased over time after AIS. During RC, the lack of FOM and POFs reveals that captivity negatively impacts S. parahybae reproduction. Nonetheless, the VTG stage of oocytes, reached during RC, is suitable for ovulation induction with artificial hormone manipulation, enabling the reproduction of this species in captivity and being essential for the success of fish farming and/or fish conservation programmes (conservationist aquaculture).
Carving Space and Time. Interruptions and (Un)Predictability in Infrastructural Design of Emeralds and the Mining Formalization in Colombia
Authors: Caraballo Acuña Vladimir 
Published: April 2022

AbstractColombia accounts for 80 percent of the world's emerald market. The famous beauty of its emeralds is due, in part, to the delicate work that carvers have been developing for decades in downtown Bogotá workshops. They articulate the materiality of the stones, their bodies, and the carving machines, and take precise measures with a paradoxical aim: to exceed them. This way, the valuable qualities of emeralds emerge as surprises from the indeterminate relationship between measures and excesses. In this article, I show that Colombian carvers do this by constructing an (un)predictable space and interrupted time, related to the linear spatiotemporality of three recent political processes in Colombia: the peace agreement with FARC, the country's entry into the OECD, and the formalization of mining. Using “resource becoming” and infrastructures studies, I argue that this spatiotemporal conflict helps us to rethink the relationship between time, labor, and unpredictability in economic formalization and national pacification contexts.
Misaligned hormonal rhythmicity: Mechanisms of origin and their clinical significance
Authors: Zavala Eder 
Published: April 2022

AbstractRhythmic hormonal secretion is key for sustaining health. While a central pacemaker in the hypothalamus is the main driver of circadian periodicity, many hormones oscillate with different frequencies and amplitudes. These rhythms carry information about healthy physiological functions, while at the same time they must be able to respond to external cues and maintain their robustness against severe perturbations. Since endocrine disruptions can lead to hormonal misalignment and disease, understanding the clinical significance of these rhythms can help support diagnosis and disease management. While the misalignment of dynamic hormone profiles can be quantitatively analysed though statistical and computational techniques, mathematical modelling can provide fundamental understanding about the mechanisms underpinning endocrine rhythms, particularly around the question of what makes them robust to some perturbations but fragile to others. In this study, I will review the key challenges of understanding hormonal rhythm misalignment from a mathematical perspective, including their causes and clinical significance. By reviewing modelling examples of coupled endocrine axes, I will address the question of how perturbations in one endocrine axis propagate to another, leading to the more complex issue of disentangling the contribution of each endocrine system to a robust dynamic environment.
Delayed complication of botulinum toxin and hyaluronic acid filler injections: A case report
Authors: Lai Dihui , Liu Hongmei , Kong Linghong , Cheng Shaowei 
Published: April 2022

AbstractBackgroundBotulinum toxin and hyaluronic acid (HA) filler injections are popular minimally invasive cosmetic procedures owing to their convenience, efficiency, and durability; however, adverse reactions often occur.Materials and methodsWe describe the delayed hypersensitivity reaction that occurred after sequential injections of botulinum toxin and HA filler.ResultsThe histopathologic and dermatoscopic findings suggested a delayed hypersensitivity reaction with the formation of a dermal foreign body granuloma. The rash resolved 2 months following treatment with antihistamines and topical steroids cream.ConclusionWe assume that local trauma during the blepharoplasty stimulated an immune response, which was the basis for this complication.
Anti‐wrinkle properties of Angelica gigas Nakai root extracts using mineral‐rich water
Authors: Kang Jung‐Wook , Cho Hang‐Eui , Choi Ho‐Min , Lee In‐Chul 
Published: April 2022

AbstractBackgroundAngelica gigas Nakai is used as an herbal pharmaceutical material in Korea.AimsTo investigate the anti‐wrinkle effects of A. gigas Nakai root extracts (ARE) using mineral‐rich water in in vitro and clinical trials.Materials and methodsThe cell viability of ARE was evaluated using a water‐soluble tetrazolium salt assay. After evaluating ARE's cytotoxicity, we used an enzyme‐linked immunosorbent assay kit to assess the effects of ARE on type I collagen in human dermal fibroblasts (HDFs). During a double‐blinded in vivo clinical study, participants were randomly assigned to use the sample and placebo formulations for the left and right sides of their face over an 8‐week period. We evaluated the anti‐wrinkle properties of the formulations using PRIMOS Lite and a global photodamage score.ResultsA. gigas Nakai root extracts cytotoxicity was evaluated in HDFs. We demonstrate that ARE increased type I collagen production by 40% at 50 μg/ml as compared with the control. The use of an ARE lotion significantly reduced the presence of crow's feet wrinkles in comparison with the use of the placebo after 8 weeks. Additionally, use of the ARE lotion led to decreased photodamage scores, indicating anti‐wrinkle effects.ConclusionThe use of ARE with mineral‐rich water has anti‐wrinkle effects in in vitro and clinical trials.
Local steroid hormone injections into hypertrophic scars resulted in depression of the lesion site and radiated linear depigmentation and atrophy surrounding the lesion: A case report
Authors: Yu Tianhang , Song Jikai , Yang Shuang , Li Jin , Chen Xin , Yang Jie 
Published: April 2022

AbstractBackgroundLocal steroid hormone injections into hypertrophic scars resulted in depression of the lesion site and radiated linear depigmentation and atrophy surrounding the lesion, which is extremely rare. We reported a case.AimOur report was designed to explore the causes of this adverse reaction.MethodWe reported a case of strange adverse reactions after steroid hormone injection for hyperplastic scars: depression of the lesion and linear‐like depigmentation and atrophy of the skin around the lesion, which did not improve after 1 year of topical drug treatment.ResultsWe considered that the injection was too deep. Steroid crystals are deposited in normal skin tissue and absorbed by the lymphatic vessel network responsible for removing macromolecules in the interstitial tissue, resulting in linear discoloration and atrophy along the lymphatic vessels.ConclusionWhen treating hyperplastic scarring, the doctor needs to strictly grasp the depth, level, and dosage of the injection and avoid such adverse reactions.
Effects of decision aids on breast reconstruction: A systematic review and meta‐analysis of randomised controlled trials
Authors: Yang Shu , Yu Lin , Zhang Chunmiao , Xu Mengmeng , Tian Qi , Cui Xuan , Liu Yantong , Yu Shuanghan , Cao Minglu , Zhang Wei 
Published: April 2022

AbstractAims and ObjectivesTo systematically evaluate the effects of decision aids for women facing breast reconstruction decision on decision conflict, decision regret, knowledge, satisfaction, anxiety and depression.BackgroundBreast reconstruction decision is not good or bad and should be guided by clinical evidence and patient preferences. Decision aids can increase the patient's decision‐making enthusiasm and ability, improve the quality of decision and promote shared decision‐making between patients and medical staff.DesignSystematic review and meta‐analysis.MethodsEight databases were conducted from the establishment of the database until October 2021. The PRISMA checklist was selected for analysis in this paper. The meta‐analysis was conducted in Review Manager 5.3. The quality of the studies was assessed using the Cochrane risk‐of‐bias tool. The result is decision conflict, decision regret, knowledge and other secondary outcomes. Sensitivity analysis and subgroup analysis were also conducted.ResultsA total of twelve randomised controlled trials (RCTs) were included in the systematic review and meta‐analysis. Meta‐analysis revealed that decision aids could significantly reduce decision conflict and decision regret, improve knowledge, satisfaction and depression and had no influence on anxiety.ConclusionsThe results of the systematic review and meta‐analysis reviewed the positive effect of decision aids on the decision‐making of women facing postmastectomy breast reconstruction. In the future, more well‐designed RCTs are needed to confirm the effects of decision aids on the decision‐making of breast reconstruction and nurses should be encouraged to take part in the development of decision aids in accordance with strict standards and apply them to breast cancer patients considering postmastectomy breast reconstruction.Relevance to clinical practiceOur study provides evidence for the effectiveness of decision aids on breast reconstruction and points to the important role of healthcare providers in the use of decision aids and in facilitating shared decision‐making.
In‐hospital education of parents of newborns may benefit from competency‐based education: A qualitative focus group and interview study among health professionals
Authors: Stelwagen Mireille , Westmaas Alvin , Van Kempen Anne , Scheele Fedde 
Published: April 2022

AbstractAims/ObjectivesThe aim of this study was to appraise health professionals' self‐reported practices in educating parents of hospitalised newborns from the perspective of competency‐based education and to identify areas for improvement of parental learning.BackgroundPatient education is essential to achieve autonomy in parents of hospitalised newborns. The literature provides descriptions of the use of various components of competency‐based education in patient education. This suggests that competency‐based education is a valuable concept for patient education.DesignA case‐based qualitative study.MethodsThree focus group discussions were conducted and 28 semi‐structured interviews with 45 health professionals who practice in a hospital setting that is designed to empower parents. The data were analysed with a framework analysis approach, using a framework of competency‐based education themes for a combined inductive and deductive content data analysis. The recommendations of the Standards for Reporting Qualitative Research checklist were followed.FindingsTwo themes of competency‐based education emerged as evidently operationalised: (1) ‘Learning climate’ and (2) ‘Role modeling’. Five themes emerged as incompletely operationalised: (1) ‘Parent curriculum based on inter‐professional consensus’; (2) ‘Transparency about the competencies needed’; (3) ‘Access to teaching’; (4) ‘Assessing and reporting results’; and (5) ‘Proficiency statements based on autonomy expectations’. Two themes did not emerge: (1) ‘Empowering parents to be active learners’ and (2) ‘Evaluation and improvement of the education program’.ConclusionsParent education is at risk of being merely on a master‐apprentice model and may be more effective if it is designed on competency‐based education principles. Identified areas for improvement are empowering parents to be ‘active learners’ and by involving them in the evaluation and improvement of the educational program. Parent education in neonatal health care may benefit from an appraisal based on competency‐based education themes.Relevance to clinical practiceAppraising parent education based on competency‐based education principles is feasible for improving the learning process towards parent autonomy.
Short‐term administration of oral relugolix before single‐port laparoscopic‐assisted vaginal hysterectomy for symptomatic uterine myomas: A retrospective comparative study with leuprorelin injection
Authors: Takeda Akihiro 
Published: April 2022

AbstractAimTo investigate the efficacy of short‐term administration of relugolix, a novel orally active gonadotropin‐releasing hormone (GnRH) antagonist, before single‐port laparoscopic‐assisted vaginal hysterectomy (LAVH) for symptomatic uterine myomas, retrospectively compared with injection of leuprorelin, a GnRH agonist.MethodsA retrospective comparative study of each 35 women with symptomatic myomas in the relugolix and leuprorelin groups.ResultsBefore administration of relugolix and leuprorelin, the median uterine volume did not differ significantly between the two groups (p = 0.53). Median uterine volume change from baseline after short‐term administration of relugolix and leuprorelin did not differ significantly (p = 0.17). Surgical duration (p = 0.84) and estimated blood loss (p = 0.48) were not different between the two groups. According to a patient questionnaire, the side effects of the drugs were not different between the two groups (p = 0.27). When patients were was asked if they wanted to have either of these drugs again, some relugolix users preferred leuprorelin due to concern about forgetting daily medication, while some leuprorelin users preferred relugolix to avoid pain at injection.ConclusionOral relugolix medication or leuprorelin injection administered before single‐port LAVH for uterine myomas yielded an equivalent reduction of uterine volume and perioperative outcomes with no significant adverse events. Patient preference for either oral daily relugolix or a monthly injection of leuprorelin could be considered when preoperative management is determined.
Organizational antecedents to bootlegging and consequences for the newness of the innovation portfolio
Authors: Globocnik Dietfried , Peña Häufler Birgit , Salomo Søren 
Published: April 2022

AbstractLiterature on strategy, innovation, and portfolio management has recently shown increased interest in the concept of planned emergence. This builds on an understanding that organizations' innovation is triggered both by deliberate top‐down management approaches as well as emergent bottom‐up processes. However, little is known on how to effectively plan emergence. In this context, bootlegging has been mentioned as a potential approach, describing instances in which employees choose to innovate without the knowledge and permission of top managers. Whereas past research has focused on the individual employee, we shift the perspective to the overall tendency of bootlegging in organizations. We investigate which organizational conditions facilitate the propensity of bootlegging becoming a widespread practice in an organization, and how this tendency is associated with the organization's innovativeness. Drawing on the theory of creative deviance, we argue that organizations deploying management practices fostering emergent and induced innovation initiatives increase structural strain and thereby bootlegging tendency in such organizations. As more innovation initiatives are elaborated outside the formal process, the number and diversity of ideas outside the strategic scope should increase. Higher bootlegging tendency is thereby proposed to be associated with higher portfolio innovativeness. Empirical evidence from the study of 930 respondents in 124 firms supports the notion that management practices supporting emergent innovation initiatives increase bootlegging tendency, which in turn increases newness of the organization's innovation portfolio. Management practices inducing a particular innovation direction are, in contrast, less prone to trigger structural strain with lesser effects on bootlegging tendencies of the organization. In sum, we contribute to the literature by providing evidence on bootlegging as a promising approach to enable “planned emergence”. We illustrate how different types of management practices can be used to regulate deviance in the organization to achieve higher degrees of newness of the organization's innovation outcomes.
Assessment of a hearing protection device on infant sleep in the neonatal intensive care unit
Authors: Bloch‐Salisbury Elisabeth , McKenna Lauren , Boland Emma , Chin Donald 
Published: April 2022

SummaryPremature infants often require prolonged hospitalisation in the neonatal intensive care unit (NICU) where they are exposed to adverse noise that may disrupt sleep and further compromise recovery and developmental outcomes. This single‐session trial assessed the effects of a novel circumaural hearing protection device (DREAMIES®; NEATCAP Medical LLC) on sleep in 10 premature infants (mean 34.1 weeks GA) in a Level III NICU. Using polysomnography (PSG), the infant's sleep was compared between three interfeed periods throughout which DREAMIES® was ON or OFF. Each infant received the same condition order, OFF1‐ON‐OFF2. The PSG 30 s epochs were scored by a rater masked to the condition as Quiet Sleep, Active Sleep, Indeterminate Sleep, and Wake. There was a 14.1% increase in sleep from OFF1 to ON (p = 0.05) and an 18.4% decrease in sleep from ON to OFF2 (p = 0.02); an analogous inverse effect was observed for wake (χ2 = 5.03, p = 0.08). There was a main effect of DREAMIES on active sleep (χ2 = 7.4, p = 0.025) due to more active sleep for ON1 (46%) compared with OFF2 (32%; p = 0.074). No significant effect was observed for quiet sleep or indeterminate sleep. On average, the sound level was 51 dBA (range 36–113 dBA) and did not differ significantly among the three periods. The strongest relationship between the minute‐by‐minute maximum sound level and movement actigraphy was observed for the OFF1 condition (ρ0.301, p < 0.001). These findings suggest that DREAMIES® may augment sleep in premature infants by reducing acute episodes of adverse noise in the NICU.
Poor sleep quality may contribute to dysfunctional illness perception, physical and emotional distress in hospitalised patients: results of a national survey of the Italian Society of Consultation‐Liaison Psychiatry
Authors: Palagini Laura , Zerbinati Luigi , Balestrieri Matteo , Belvederi Murri Martino , Caruso Rosangela , D'Agostino Armando , Ferrara Maria , Ferrari Silvia , Minervino Antonino , Massa Lucia , Milia Paolo , Miniati Mario , Maria Giulia Nanni , Petrucci Alessandra , Pini Stefano , Politi Pierluigi , Porcellana Matteo , Rocchetti Matteo , Taddei Ines , Toffanin Tommaso , Grassi Luigi 
Published: April 2022

SummaryDistress associated with physical illness is a well‐known risk factor for adverse illness course in general hospitals. Understanding the factors contributing to it should be a priority and among them dysfunctional illness perception and poor sleep quality may contribute to it. As poor sleep quality is recognised as a major risk factor for health problems, we aimed to study its association with illness perception and levels of distress during hospitalisation. This cross‐sectional study included a consecutive series of 409 individuals who were hospitalised in medical and surgical units of different hospitals located throughout the Italian national territory and required an assessment for psychopathological conditions. Sleep quality was assessed with the Pittsburgh (Sleep Quality Index), emotional and physical distress with the Edmonton Symptom Assessment System (ESAS), and illness perception with the Brief Illness Perception Questionnaire (BIPQ). Differences between groups, correlations and mediations analyses were computed. Patients with poor sleep quality were more frequently females, with psychiatric comorbidity, with higher scores in the ESAS and BIPQ. Poor sleep quality was related to dysfunctional illness perception, and to both emotional and physical distress. In particular, by affecting cognitive components of illness perception, poor sleep quality may, directly and indirectly, predict high levels of distress during hospitalisation. Poor sleep quality may affect >70% of hospitalised patients and may favour dysfunctional illness perception and emotional/physical distress.Assessing and treating sleep problems in hospitalised patients should be included in the routine of hospitalised patients.
The adolescent pattern of sleep spindle development revealed by HD‐EEG
Authors: Bocskai Gábor , Pótári Adrián , Gombos Ferenc , Kovács Ilona 
Published: April 2022

SummarySleep spindles are developmentally relevant cortical oscillatory patterns; however, they have mostly been studied by considering the entire spindle frequency range (11–15 Hz) without a distinction between the functionally and topographically different slow and fast spindles, using relatively few electrodes and analysing wide age‐ranges. Here, we employ high‐density night sleep electroencephalography in three age‐groups between 12 and 20 years of age (30 females and 30 males) and analyse the adolescent developmental pattern of the four major parameters of slow and fast sleep spindles. Most of our findings corroborate those very few previous studies that also make a distinction between slow and fast spindles in their developmental analysis. We find spindle frequency increasing with age. A spindle density change is not obvious in our study. We confirm the declining tendencies for amplitude and duration, although within narrower, more specific age‐windows than previously determined. Spindle frequency seems to be higher in females in the oldest age‐group. Based on the pattern of our findings, we suggest that high‐density electroencephalography, specifically targeting slow and fast spindle ranges and relatively narrow age‐ranges would advance the understanding of both adolescent cortical maturation and development and the functional relevance of sleep spindles in general.