bluuebunny/crossref_metadata_2025_split huggingface dataset:
Navigating the initial stages of the pandemic using knowledge management: An integrated framework
Authors: Elembilassery Varun , Chakraborty Shreyashi , Chandrasekaran Shabana 
Published: September 2022

AbstractKnowledge management is a key driver of competitive advantage at all times. This paper explores the different knowledge management measures taken by organizations during the initial stages of the pandemic and the various knowledge resources leveraged for the same. The scope of the study is limited to the initial stages of the pandemic, when things were uncertain and most organizations were going through such a crisis for the first time. The methodology used in this paper combines three‐stage thematic coding and a topic modelling algorithm. The data consist of interviews of human resource leaders and articles published in globally renowned sources. The data was collected during the initial stages of the pandemic and it reflects the thorough process during the initial stages of the pandemic. The findings indicate that firms take various short‐term and long‐term knowledge management measures by leveraging on several internal and external knowledge resources. The findings were analytically clustered and theoretically aggregated to develop an integrated framework for organizational navigation during the initial stages of the pandemic. The paper contributes to the literature by making a novel attempt to study the measures taken in the very early stages of the pandemic and some findings are new to the literature. Also, this paper integrates two different methodologies, which is unique to research. The integrated framework could be used by practitioners for developing a resilient knowledge management system.
Optimal Timing of the Salivary Pepsin Test for the Diagnosis of Laryngopharyngeal Reflux
Authors: Zhang Jinhong , Wang Xiaoyu , Wang Jiasen , Zhao Jing , Zhang Chun , Liu Zhi , Li Jinrang 
Published: September 2022

ObjectiveTo investigate the optimal time point for diagnosing laryngopharyngeal reflux (LPR) through combining 24‐h hypopharyngeal‐esophageal multichannel intraluminal impedance‐pH (24‐h HEMII‐pH) monitoring and the multi‐time point salivary pepsin test (MTPSPT).Study DesignProspective uncontrolled trial.MethodPatients with and without LPR symptoms were included as the test group and the control group, respectively. The patients in the test group underwent 24‐h HEMII‐pH and MTPSPT. The results of 24‐h HEMII‐pH were used as a diagnostic criterion for LPR, and the diagnostic value of salivary pepsin tests performed at different time points was compared by receiver operating characteristic (ROC) analysis.ResultsA total of 153 patients were included. Based on 24‐h HEMII‐pH, the positive rate of LPR in the test group of patients was 84.00%. In the control group, only one person (3.57%) had a positive salivary pepsin test result. The area under the curve (AUC) of the MTPSPT was 0.827. In addition, we separately calculated the AUC of the combined salivary pepsin test at different time points, and found good diagnostic value (AUC = 0.799) when the test was combined with the waking, 1 and 2 h after breakfast and lunch, and 1 h after dinner tests. However, when the number of tests were further increased, the diagnostic value did not improve significantly.ConclusionSalivary pepsin testing combined with waking, 1 h and 2 h after breakfast and lunch, and 1 h after dinner has almost the same diagnostic value as MTPSPT, and testing at these time points can be an effective method for diagnosing LPR.Level of Evidence3 Laryngoscope, 133:1706–1711, 2023
Titles in research articles: Changes across time and discipline
Authors: Jiang Feng Kevin , Hyland Ken 
Published: September 2022

AbstractTitles are a crucial feature of research papers and have become increasingly important with changes in publishing practices and the explosion of published research. As a result, novice writers seeking to get their work noticed in international journals might benefit from a clear understanding of the features of research titles and an awareness of the relationship between language and disciplinary context. In this study, we explore this relationship and the impact of changing contexts on titles across the last 60 years on the length, form and content of 36,000 titles from the 10 leading journals from six disciplines spread along a soft‐hard science continuum. Our results show a considerable increase in the length of titles coupled with more interrogative and compound titles in almost all disciplines. There has also been a growing mention of methods in the titles of hard knowledge papers with more frequent inclusion of results in the softer domains. These diachronic changes can be attributed to different characteristics of the fields and of the changing dynamics of the publishing context. Our findings have important implications for early career academics seeking to publish in English and contribute to studies of diachronic analysis of academic discourse.
Examining ecological succession of diatoms in California Current System cyclonic mesoscale eddies
Authors: Abdala Zuzanna M. , Clayton Sophie , Einarsson Sveinn V. , Powell Kimberly , Till Claire P. , Coale Tyler H. , Chappell P. Dreux 
Published: September 2022

AbstractThe California Current System is a diatom‐dominated region characterized by seasonal coastal upwelling and additional elevated mesoscale activity. Cyclonic mesoscale eddies in the region trap productive coastal waters with their planktonic communities and transport them offshore with limited interaction with surrounding waters, effectively acting as natural mesocosms, where phytoplankton populations undergo ecological succession as eddies age. This study examines diatom community composition within two mesoscale cyclonic eddies that formed in the same region of the California Current System 2 months apart and in the California Current waters surrounding them. The diatom communities were analyzed in the context of shifting environmental gradients and through a lens of community succession to expand our understanding of biophysical interactions in California Current System cyclonic eddies. Diatom communities within each eddy were different from non‐eddy communities and varied in concert with salinity and dissolved iron (Fe) concentrations. The younger, nearshore eddy displayed higher macronutrient and dissolved Fe concentrations, had higher values for diatom Shannon diversity and evenness, and had nutrient ratios indicative of either eventual silicic acid (Si) or Fe limitation or possibly co‐limitation. The older, offshore eddy displayed low macronutrient and dissolved Fe concentrations, was likely nitrate‐limited, and had lower diatom Shannon diversity and evenness indices. Sequences from the genus Rhizosolenia, some of which form vertically migrating mats to bypass nitrate limitation, dominated in the older eddy. This is of potential significance as the prevalence of Rhizosolenia mats could impact estimates of carbon cycling and export in the wider California coastal area.
Thermosensitive Injectable Gradient Hydrogel‐Induced Bidirectional Differentiation of BMSCs
Authors: Bi Gangyuan , Liu Sa , Zhong Xiupeng , Peng Yaotian , Song Wenjing , Yang Junzhong , Ren Li 
Published: September 2022

AbstractOsteochondral defects threaten the quality of life of patients to a great extent. To simulate gradient changes in osteochondral tissue, a gradient‐mixing injection device consisting of a controller and injection pumps is design. Bioactive glass (BG) and gellan gum (GG) are used to prepare thermosensitive injectable gradient hydrogels (B0.5G, B1G) with an upper critical solution temperature (UCST) range of 37.7–40.2 °C using this device for the first time. The mechanical properties of gradient hydrogels are significantly better than those of pure GG hydrogels. The gradients in the composition, structure, and morphology of gradient hydrogels are confirmed via physicochemical characterization. Cytocompatibility tests show that hydrogels, especially B0.5G gradient hydrogels, promote the proliferation of bone marrow mesenchymal stem cells (BMSCs). Most importantly, qRT‐PCR shows that the different components in B0.5G gradient hydrogels simultaneously induce the osteogenic and chondrogenic differentiation of BMSCs. Experimental injection in porcine osteochondral defects indicates that the B0.5G gradient hydrogel seamlessly fills irregular osteochondral defects in a less invasive manner by controlling the temperature to avoid cellular and tissue damage arising from crosslinkers or other conditions. These results show that thermosensitive injectable B0.5G gradient hydrogels have the potential for less invasive integrated osteochondral repair.
Synergistic Effects of Iron Alginate on Improving the Fire Safety and Mechanical Properties of Epoxy Resin/Ammonium Polyphosphate Composites
Authors: Liu Chang , Li Ping , Xu Ying‐Jun , Liu Yun , Zhu Ping 
Published: September 2022

AbstractIron alginate is chosen as an eco‐friendly synergist to improve the flame retardancy, smoke suppression, and mechanical properties of epoxy resin/ammonium polyphosphate composites (EP/APP). The suitable additive amount of iron alginate further enhances the char‐forming ability in the higher‐temperature range and flame retardancy of EP/APP. EP/APP9.0‐iron alginate1.0 retains a char residue of 33.3% at 700 °C and obtains a limiting oxygen index value of 28.4% and vertical burning test (UL‐94) V‐0 rating, while EP/APP10 has no UL‐94 rating. The burning behaviors of EP/APP9.0‐iron alginate1.0 are also suppressed; and the total smoke production value is much lower than that of EP/APP10. EP/APP9.0‐iron alginate1.0 releases less smoke and flammable fragments. The suitable additive amount of iron alginate boosts the mechanical properties of EP/APP, while APP destroys the mechanical properties of EP. Therefore, the addition of suitable amount of iron alginates can further reduce the fire hazard, and improve the mechanical properties of EP/APP composites.
Association of ACE1 I/D rs1799752 and ACE2 rs2285666 polymorphisms with the infection and severity of COVID‐19: A meta‐analysis
Authors: Aziz Md. Abdul , Islam Mohammad Safiqul 
Published: September 2022

AbstractBackgroundACE1 I/D rs1799752 and ACE2 rs2285666 genetic polymorphisms could play a critical role in altering the clinical outcomes of SARS‐CoV‐2. The findings of previous studies remained inconclusive. This meta‐analysis was performed to evaluate the association and provide a more reliable outcome.MethodsThis study was completed following the updated recommendations of PRISMA using RevMan 5.4.1 statistical software.ResultsA total of 11 studies with 950 severe cases and 1573 non‐severe cases with COVID‐19 infection were included. Pooled analysis showed that ACE1 I/D polymorphism was correlated with the severity of SARS‐CoV‐2 in the DD genotype and D allele for the fixed‐effects model (OR:1.27 and OR:1.17). Besides, codominant 3, recessive, and allele models were associated with the severity of the fixed‐effects model (OR:1.35, OR:1.37, and OR:1.20) in Caucasian ethnicity. ACE2 rs2285666 was linked with the severity in codominant 3 (OR:2.63, for both random‐ and fixed effects‐models), overdominant (OR:1.97, for random‐effects model and OR:1.97, for fixed effects‐model), and recessive model (OR:0.41 for fixed‐ and random‐effects model). Allele model of rs2285666 showed a significant association in the fixed‐effects model (OR:1.61).ConclusionOur present meta‐analysis suggests that ACE1 I/D rs1799752 and ACE2 rs2285666 variants may enhance the severity in SARS‐CoV‐2 infected patients. Future studies are warranted to verify our findings.
A novel SYNJ1 homozygous variant causing developmental and epileptic encephalopathy in an Afro‐Caribbean individual
Authors: Maj Mary , Taylor Christie L. , Landau Kevin , Toriello Helga V. , Li Dong , Bhoj Elizabeth J. , Hakonarson Hakon , Nelson Beverly , Gluschitz Sarah , Walker Ruth H. , Sobering Andrew K. 
Published: September 2022

AbstractBackgroundSYNJ1 encodes Synaptojanin‐1, a dual‐function poly‐phosphoinositide phosphatase that is expressed in the brain to regulate neuronal synaptic vesicle dynamics. Biallelic SYNJ1 variants cause a spectrum of clinical manifestations, from early onset parkinsonism to developmental and epileptic encephalopathy.MethodsProband‐only exome sequencing was used to identify a homozygous SYNJ1 pathogenic variant in an individual with epileptic encephalopathy. Sanger sequencing was used to confirm the variant.ResultsWe present an Afro‐Caribbean female who developed uncontrollable seizures shortly after birth, accompanied by developmental delay and severe generalized dystonia. She had homozygosity for a novel c.242‐2A > G variant in SYNJ1 with both parents being heterozygous carriers. An older sister was reported to have had a similar presentation but was not examined. Both siblings died at an approximate age of 16 years.ConclusionsWe report a novel pathogenic variant in SYNJ1 present in homozygosity leading to developmental and epileptic encephalopathy. Currently, there are only 4 reports describing 10 individuals with SYNJ1‐related developmental and epileptic encephalopathy. This case expands the clinical knowledge and the allelic heterogeneity associated with SYNJ1 variants.
Hypoplastic model with fabric change effect and semifluidized state for post‐liquefaction cyclic behavior of sand
Authors: Liao Dong , Yang Zhongxuan , Wang Shun , Wu Wei 
Published: September 2022

AbstractThis paper presented the formulation of a novel hypoplastic model for sand considering both the cyclic mobility and large accumulative shear deformation in the post‐liquefaction stage. Based on experimental observations and existing modeling response, two constitutive ingredients were incorporated into the hypoplastic model to improve its prediction accuracy. First, the fabric change effect was considered, enabling a satisfactory simulation of effective stress reduction under undrained cyclic loading. The second component was the introduction of the semifluidized state concept to reflect the modulus degradation and deviatoric strain development of sand at low‐stress state. The capability of the proposed model is demonstrated by the comparisons between the model responses and experimental results of the cyclic behavior of sand under different test conditions. Remarkably, the liquefaction phenomenon and increasing deviatoric strain amplitude during the post‐liquefaction stage were reproduced well by the model.
Effect of excessive gestational weight gain on insulin sensitivity and insulin kinetics in women with overweight/obesity
Authors: Cade William Todd , Mittendorfer Bettina , Patterson Bruce W. , Haire‐Joshu Debra , Cahill Alison G. , Stein Richard I. , Schechtman Kenneth B. , Tinius Rachel A. , Brown Katherine , Klein Samuel 
Published: September 2022

AbstractObjectiveObesity increases the risk for pregnancy complications and maternal hyperglycemia. The Institute of Medicine developed guidelines for gestational weight gain (GWG) targets for women with overweight/obesity, but it is unclear whether exceeding these targets has adverse effects on maternal glucose metabolism.MethodsInsulin sensitivity (assessed using the Matsuda Insulin Sensitivity Index), β‐cell function (assessed as insulin secretion rate in relation to plasma glucose), and plasma insulin clearance rate were evaluated using a frequently sampled oral glucose tolerance test at 15 and 35 weeks of gestation in 184 socioeconomically disadvantaged African American women with overweight/obesity.ResultsInsulin sensitivity decreased, whereas β‐cell function and insulin clearance increased from 15 to 35 weeks of gestation in the entire group. Compared with women who achieved the recommended GWG, excessive GWG was associated with a greater decrease in insulin sensitivity between 15 and 35 weeks. β‐cell function and plasma insulin clearance were not affected by excessive GWG.ConclusionsThese data demonstrate that gaining more weight during pregnancy than recommended by the Institute of Medicine is associated with functional effects on glucose metabolism.
Do thrifty genes exist? Revisiting uricase
Authors: Johnson Richard J. , Sánchez‐Lozada Laura G. , Nakagawa Takahiko , Rodriguez‐Iturbe Bernardo , Tolan Dean , Gaucher Eric A. , Andrews Peter , Lanaspa Miguel A. 
Published: September 2022

AbstractSixty years ago, the geneticist James Neel proposed that the epidemics of obesity and diabetes today may have evolutionary roots. Specifically, he suggested that our ancestors may have accumulated mutations during periods of famine that provided a survival advantage at that time. However, the presence of this “thrifty genotype” in today's world, where food is plentiful, would predispose us to obesity and diabetes. The “thrifty gene” hypothesis, attractive to some, has been challenged over the years. The authors have previously postulated that the loss of the uricase gene, resulting in a rise in serum and intracellular uric acid levels, satisfies the criteria of a thrifty genotype mutation. This paper reviews and brings up‐to‐date the evidence supporting the hypothesis and discusses the current arguments that challenge this hypothesis. Although further studies are needed to test the hypothesis, the evidence supporting a loss of uricase as a thrifty gene is substantial and supports a role for evolutionary biology in the pathogenesis of the current obesity and diabetes epidemics.
Design, fabrication and evaluation of amphiphilic hyaluronic acid conjugates as efficient carriers of 6‐thioguanine for in vitro anticancer drug delivery applications
Authors: Deka Smriti R , Singh Reena , Verma Pratiksha , Kumar Pradeep 
Published: September 2022

AbstractNanoparticle‐based polymeric carriers are highly desirable for efficient delivery of hydrophobic drugs. The development of nanocarriers with high encapsulation efficiency synthesized by a simple emulsification technique has become a challenging task with their controlled and sustained release ability at disease sites. Here, we have synthesized a series of hydrophobically modified hyaluronic–dodecylamide (HD) conjugates by coupling dodecylamine onto hyaluronic acid in varying amounts and characterized them using physicochemical techniques. The synthesized HD conjugates, in an aqueous medium, self‐assembled into nanoparticles of size in the range of ca 189–355 nm with hydrophilic surface and hydrophobic core. 6‐Thioguanine (TG) was used as a model drug for encapsulation into the hydrophobic core of the conjugate (HD‐2) by the standard emulsification technique with high encapsulation efficiency. Spectrophotometric analysis revealed that the drug‐loaded nanoconjugate showed a sustained release of drug over a period of time and also showed enzymatic responsiveness towards hyaluronidase. In vitro experiments were performed with HEK293, HeLa and HepG2 cells and it was observed that drug‐loaded nanoparticles were more toxic towards cancerous cells as compared with free TG. These results advocate that the reported system, being biocompatible, could be used as promising anticancer drug delivery system. © 2022 Society of Industrial Chemistry.
Are physical activity and nutrition linked to personality disorders? Health habits and personality disorders: A scoping review
Authors: St‐Amour Samuel , Bérubé Félix‐Antoine , Cailhol Lionel , Le Corff Catherine 
Published: September 2022

AbstractIndividuals with personality disorders (PDs) have a decreased life expectancy compared with the general population in part due to physical illnesses. Many hypotheses have been suggested to explain those physical illnesses such as hormone imbalance, medication, lack of physical activity, and unhealthy diet. However, little is known about the relation between lifestyle and PDs. The purpose of this scoping review is to regroup the available information on this topic. We searched the literature up to February 2021 using four databases and found 21 articles analyzing the relation between lifestyle and PDs in observational studies including 153,081 participants from diverse populations going from general population to adults in psychiatric care. Most studies used measures of lifestyle as control variables or did not use lifestyle variables at all. Moreover, the instruments used to measure lifestyle variables lacked precision at best. Two studies demonstrated a relation between early malnutrition and further development of PDs, but those results may be influenced by confounding variables and cannot indicate a clear link between nutrition and personality disorder. The lack of solid evidence we observed is surprising, considering the multiple benefits individuals with PDs could get from a healthy lifestyle. More studies are needed to thoroughly analyze the impact of lifestyle on PDs and vice versa.
Studies of Energetic and Non‐Energetic Plasticizers for Nitrile Butadiene Rubber based CSP
Authors: Singh Sudhir , Raveendran Sidharth , Kshirsagar Dhirendra R. , Somraj  , Kumar Arvind , Bhongale Chetan J. , Gupta Manoj 
Published: September 2022

AbstractBinders with energetic plasticizers besides boosting energy also enhance the structural integrity of the propellant composition. In recent energetic compositions, energetic plasticizers such as NG, BTTN, DEGDN and TEGDN replace conventional plasticizers as they possess positive heat of the explosion and energetic groups in the same molecule. Energetic groups impart enhanced potential for delivering superior performance. In the present paper, a comparative study is done between NBR based composite solid propellant formulations with energetic (DEGDN and TEGDN) and non‐energetic (DAP and DBP) plasticizers. The predicted theoretical performance of non‐aluminized and aluminized propellants shows that DEGDN/TEGDN based propellants are more energetic than that of DAP/DBP propellants. The viscosity (768 Pa.s), density (1748 kg/m3), cal‐val (5426.64 J/g), burning rate (4.21 mm/s) of DBP and DAP based propellants are on the lower side than DEGDN and TEGDN based propellants. End of mix viscosity and burning rate of energetic plasticizer based compositions is approximately twice of the inert plasticizer based compositions. There is up to 60 % increase in TS and modulus while elongation is reduced by 20 %. Pressure index increases from 0.159 to 0.310 for DBP to DEGDN based propellant. The study shows that high performance high burning rate propellant can be designed with DEGDN.
Extraction, Fractional Structure and Physiological Activities of Fulvic Acid from Yunnan Xundian Lignite
Authors: Gong Guanqun , Liang Shaojie , Zhang Yingjie , Zhang Yongzhen , Sanjaa Batbileg , Zhang Fushui , Wang Ziyan , Li Zhiling , Li Ruonan , Lu Shan 
Published: September 2022

AbstractThe efficient conversion of lignite is important for environmental protection. Coal‐based fulvic acid (FA) was prepared by the oxidative degradation of lignite in a microwave field. The highest extraction rate of FA was 35.03 %. To reduce the heterogeneity of FA, it was divided into four fractions‐FAI, FAII, FAIIIand FAIV‐with molecular weights of <500, 500–1000, 1000–3500, and >3500 Da, respectively. A variety of characterisation methods revealed that all the FA fractions contained carboxyl, phenolic hydroxyl, amino and sulfhydryl groups. The FAIcontained the most oxygen‐containing functional groups. The benzene rings of the >1000 Da FA fractions were mostly tri‐substituted. FA could break dormancy and promote the germination of coreopsis seeds but this effect was weakened when the FA concentration was too high. FAIcould effectively promote chlorophyll synthesis, FAIIcould effectively improve plant stress resistance and FAIIIpromoted seedling longitudinal growth.