bluuebunny/crossref_metadata_2025_split huggingface dataset:
Gamma, X-ray, and neutron shielding properties of silicon–germanium alloys
Authors: Sathish K.V. , Manjunatha H.C. , Vidya Y.S. , Seenappa L. , Sridhar K.N. , Gupta P.S. Damodara , Raj Alfred Cecil 
Published: June 2022

This work focuses on the gamma/X-ray and neutron shielding properties of silicon–germanium alloys in different compositions such as Si0.1Ge0.9 (SG1), Si0.2Ge0.8, Si0.4Ge0.6, Si0.6Ge0.4, Si0.8Ge0.2, and Si0.9Ge0.1. Among all the selected alloys, SG1 has less half-value thickness, tenth-value thickness, and penetration depth, whereas specific gamma-ray constant, Zeff, electron density, radiation protection efficiency, and kinetic energy released in matter have larger values compared to the other studied alloys. The neutron shielding parameters, such as coherent neutron scattering length, incoherent neutron scattering length, coherent neutron scattering cross-section, and incoherent neutron scattering cross-sections are smaller for the SG1 alloy than the other studied alloys. Furthermore, total neutron scattering cross-section and neutron absorption cross-section are found to be larger for SG1 than the other studied alloys. Based on gamma/X-ray and neutron shielding parameter analysis, we have suggested a shielding material consisting of ordinary concrete and SG1 alloy of particular thickness to cease X-ray/gamma-ray and neutron radiation. By analyzing all these parameters, we suggest that the SG1 alloy might be a good shielding material for X-rays/gamma-rays and for neutrons compared to other selected alloys.
Solutions of the Dirac equation with position-dependent mass for q-deformed Pöschl–Teller and Coulomb-like tensor potentials
Authors: Bouledjedj S. , Khodja A. , Benamira F. , Guechi L. 
Published: June 2022

We consider the Dirac equation with position-dependent mass for a q-deformed Pöschl–Teller potential plus a Coulomb-like tensor interaction in the limits of spin and pseudospin symmetries. Under the condition of spin symmetry, the bound state energy eigenvalue equation and the two radial components of the Dirac wave function in terms of the Jacobi polynomials are obtained approximately for an arbitrary shifted spin-orbit quantum number λκ = κ + H and for any value of the deformation parameter q ≥ 1. In the case of the pseudospin symmetry limit, there are no bound states. The Dirac equation describes a free physical system and the two components of the wave function are expressed in terms of the spherical Bessel functions.
Noether symmetry approach in non-minimal derivative coupling gravity
Authors: Dolohtahe Muhammadsorfee , Srikom Watcharakorn , Channuie Phongpichit , Kaewkhao Narakorn 
Published: June 2022

AbstractIn this work, we examine solutions of the system of equations obtained by applying the Noether gauge symmetry (NGS) and its conserved quantity for the standard general relativity (GR) and the non-minimal derivative coupling (NMDC) cosmological model. We discover two salient features of the solutions. The first one is $$a(t)\propto t^{1/3}$$

a

(
t
)

∝

t

1
/
3

for a kinetic-dominant phase which may emerge before inflationary period at very early time for GR case. The second one is a new form of scalar field $$\phi (t)$$

ϕ
(
t
)

govern by the exponential cosmological solution for NMDC case, $$\phi (t)=(c_{1}+c_{2}t)e^{-\lambda t}+c_{3}$$

ϕ

(
t
)

=

(

c
1

+

c
2

t
)

e

-
λ
t

+

c
3

.
Derivation of the two Schwarzians effective action for the Sachdev–Ye-Kitaev spectral form factor
Authors: Cardella Matteo A. 
Published: June 2022

AbstractThe Sachdev–Ye-Kitaev model spectral form factor exhibits absence of information loss, in the form of a ramp and a plateau that are typical in random matrix theory. In a large N collective fields description, the ramp was reproduced by Saad et al. (A semiclassical ramp in SYK and in gravity, arXiv:1806.06840) by replica symmetry breaking saddles. We derive a two sides Schwarzians effective action for fluctuations around the ramp critical saddles, by computing responses to a smeared version of the two replica kinetic kernel. Our result confirms [1], where the form of the action was heuristically guessed by indirect arguments supported by numerical evidences.
Minimally deformed charged stellar model by gravitational decoupling in 5D Einstein–Gauss–Bonnet gravity
Authors: Maurya S. K. , Banerjee Ayan , Pradhan Anirudh , Yadav Dhananjay 
Published: June 2022

AbstractWe investigate the possibility of existing a class of compact charged spheres made of a charged perfect fluid in the framework of Einstein–Gauss–Bonnet theory in five-dimensional spacetime (5D EGB). In order to study spherically symmetric compact stars in EGB gravity, we prefer to apply a systematic and direct approach to decoupling gravitational sources via the minimal geometric deformation approach (MGD), which allows us to prove that the fluid must be anisotropic. In fact, we specify a well-known Krori–Barua spacetime in the MGD approach that helps us to determine the decoupling sector completely. Indeed, by using this approach, we found an exact and physically acceptable solution which satisfies all the elementary criteria of physical acceptability for a stellar solution via mimic approach. Finally, we show that the compactness factor in the presence of gravitational decoupling satisfies the Buchdahal limit under 5D EGB gravity.
A machine learning-based methodology for pulse classification in dual-phase xenon time projection chambers
Authors: Brás P. , Neves F. , Lindote A. , Cottle A. , Cabrita R. , Asamar E. Lopez , Pereira G. , Silva C. , Solovov V. , Lopes M. I. 
Published: June 2022

AbstractMachine learning techniques are now well established in experimental particle physics, allowing detector data to be analyzed in new and unique ways. The identification of signals in particle observatories is an essential data processing task that can potentially be improved using such methods. This paper aims at exploring the benefits that a dedicated machine learning approach might provide to the classification of signals in dual-phase noble gas time projection chambers. A full methodology is presented, from exploratory data analysis using Gaussian mixture models and feature importance ranking to the construction of dedicated predictive models based on standard implementations of neural networks and random forests, validated using unlabeled simulated data from the LZ experiment as a proxy to real data. The global classification accuracy of the predictive models developed in this work is estimated to be >99.0%, which is an improvement over conventional algorithms tested with similar data. The results from the clustering analysis were also used to identify anomalies in the data caused by miscalculated signal properties, showing that this methodology can also be used for data monitoring.
Towards a full general relativistic approach to galaxies
Authors: Astesiano Davide , Cacciatori Sergio L. , Gorini Vittorio , Re Federico 
Published: June 2022

AbstractWe analyse the dynamics of a single disk galaxy from a general relativistic viewpoint. We investigate dark matter (DM) effects in terms of a known family of stationary axially-symmetric solutions of Einstein equations coupled to a rotating dust. These effects are generated by the non-Newtonian features of such solutions and are ascribed to the essential role of frame dragging. Indeed, in such models, the off-diagonal elements of the metric are, in general, of the same order of magnitude of the diagonal ones. We generalize the results of Balasin and Grumiller (BG) to the physical case of differentially rotating dust. In particular, we find that for differential rotation the amount of energy density required to account for the flat rotation curves of disk galaxies is reduced with respect to the BG rigid rotation case. This stresses the discrepancy between Newtonian gravity and general relativity (GR), even at low velocities and low energy densities.
Toxicogenic Fungi, Aflatoxins, and Antimicrobial Activities Associated with Some Spices and Herbs from Three Selected Markets in Ho Municipality, Ghana
Authors: Kortei Nii Korley , Djaba Barnabas Teye , Tettey Clement Okraku , Agyemang Alfred Ofori , Aninagyei Enoch , Essuman Edward Ken , Boakye Adjoa Agyemang , Annan Theophilus 
Published: June 2022

Spices and herbs are widely used food ingredients that enhance most organoleptic features of prepared foods. They are also used for medicinal and preservative purposes. Spices and herbs are potential carriers of bacteria, yeasts, and molds due to the nature of cultivation, harvest methods, storage conditions, packaging procedures, distribution, sale, and general handling. Although some fungi have been identified to be associated with most spices and herbs elsewhere in the world, little has been done on the presence of fungi in spices and herbs in Ghana. This study sought to identify the toxicogenic fungal profiles, mycotoxins (aflatoxins) present in some herbs, bay leaf (Laurus nobilis) and garden egg leaves (“gboma”) (Solanum macrocarpon), and spices, ginger (Zingiber officinale) and “dawadawa”(Parkia biglobosa), as well as to investigate the antimicrobial properties of the selected herbs and spices. The decimal reduction technique was used to plate onto Dichloran Rose Bengal Chloramphenicol (DRBC) agar media plates for fungal growth. Aflatoxin detection was carried out with high-performance liquid chromatographer connected to a fluorescence detector (HPLC-FLD). Antimicrobial properties were carried out using the agar diffusion method on solidified, freshly prepared Mueller-Hinton agar. A total of 12 species belonging to 7 genera, Aspergillus (niger, flavus, fumigatus, and ochraceus), Fusarium (oxysporum, verticillioides), Mucor (racemosus), Penicillium (digitatum, expansum), Rhizopus (stolonifer), Rhodotorula sp., and Trichoderma harzianum, were identified as fungal contaminants. Fusarium oxysporum was the most predominant species identified. Fresh ginger recorded the greatest number of colony-forming units (3.71 log10 CFU/g) with bay leaves recording the least number of colony counts (2.36 log10 CFU/g). Mycotoxin concentration detected in gboma was

2.06
±
0.07

μ
g
/
kg

and in dawadawa was

2.13
±
0.09

μ
g
/
kg

; however, mycotoxins were not detected in bay leaf and ginger. Ginger exhibited antibacterial activity against all bacteria ranging from

7.0
±
0.0

mm

to

12.0
±
5.66

mm

zones of inhibition. Ginger, bay leaf, and gboma extracts displayed fair antimicrobial activity against the bacteria investigated. On the other hand, dawadawa generally produced the least resistance against the five bacterial species but exhibited the highest zone of inhibition. All samples were slightly acidic with pH readings ranging from 5.81 to 6.76.
Abstract P1-07-06: The relationship between Klintrup-Makinen score and cancer-specific survival in primary operable breast cancer
Authors: Morrow ES , Gujam F , Mohammed ZMA , McMillan DC , Edwards J 
Published: June 2022

Abstract
Introduction
It is increasingly being recognised that cancer prognosis is dependent on a complex interaction of tumour factors and the host response. The degree of inflammatory response at the invasive tumour edge, as measured by the Klintrup-Makinen score, has been shown to have prognostic relevance in some cancers but its role in breast cancer remains unclear.
Aim
To evaluate the relationship between Klintrup-Makinen score and prognosis in primary operable breast cancer.
Methods
Patients who underwent surgery for primary operable invasive breast cancer between 1995 and 2007 were studied. Full section haematoxylin and eosin slides from surplus tissue from each breast cancer were analysed. Each was visually scored for the level of inflammatory infiltrate at the invasive edge of the tumour, according to Klintrup-Makinen criteria. Kaplan Meier survival analysis was performed using SPSS.
Results
1195 patients were included in the study, of which 298 had a Klintrup-Makinen score (KM) of 0 (no inflammatory cells at the invasive edge), 589 had a score of 1, 238 had a score of 2 and 70 had a Klintrup-Makinen score of 3 (high inflammatory cell infiltrate). 833 (69.7%) patients were ER positive and 172 (14.4%) patients were HER2 positive. Median follow up was 158 months (28-183) and there were 234 cancer deaths. Patients with the highest and lowest KM scores had the best prognosis (10 year breast cancer specific survival (BCSS) 84% for KM score 3 and 82% for KM score 0), while those with KM score 2 had the worst prognosis with 67% 10 year cancer specific survival (p=0.003). When analysed by subtype, in ER negative patients 10 year BCSS was 95% in KM 0 patients, 80% for KM 3, 72% for KM 1 and 67% for KM 2 (p=0.082). Conversely, in HER2 positive patients, the best prognosis was seen in patients with KM 3 with 86% 10 year BCSS but patients with KM 0 had the worst prognosis (BCSS 62%), but this did not reach significance (p=0.544).
Conclusion
The Klintrup-Makinen score appears to have a prognostic role in primary operable invasive breast cancer, however there is a suggestion that it varies between tumour subtypes. Further work is required to further define this role for each molecular subtype.
Citation Format: Morrow ES, Gujam F, Mohammed ZMA, McMillan DC, Edwards J. The relationship between Klintrup-Makinen score and cancer-specific survival in primary operable breast cancer [abstract]. In: Proceedings of the 2017 San Antonio Breast Cancer Symposium; 2017 Dec 5-9; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2018;78(4 Suppl):Abstract nr P1-07-06.
Adoptive Cellular Therapy with Autologous Tumor-Infiltrating Lymphocytes and T-cell Receptor–Engineered T Cells Targeting Common p53 Neoantigens in Human Solid Tumors
Authors: Kim Sanghyun P. , Vale Nolan R. , Zacharakis Nikolaos , Krishna Sri , Yu Zhiya , Gasmi Billel , Gartner Jared J. , Sindiri Sivasish , Malekzadeh Parisa , Deniger Drew C. , Lowery Frank J. , Parkhurst Maria R. , Ngo Lien T. , Ray Satyajit , Li Yong F. , Hill Victoria , Florentin Maria , Masi Robert V. , Paria Biman C. , Levin Noam , Bera Alakesh , Hedges Elizabeth A. , Choi Agnes , Chatani Praveen D. , Parikh Anup Y. , Levi Shoshana , Seitter Samantha , Lu Yong-Chen , Zheng Zhili , Prickett Todd D. , Jia Li , Hernandez Jonathan M. , Hoang Chuong D. , Robbins Paul F. , Goff Stephanie L. , Sherry Richard M. , Yang James C. , Rosenberg Steven A. 
Published: June 2022

Abstract
Adoptive cellular therapy (ACT) targeting neoantigens can achieve durable clinical responses in patients with cancer. Most neoantigens arise from patient-specific mutations, requiring highly individualized treatments. To broaden the applicability of ACT targeting neoantigens, we focused on TP53 mutations commonly shared across different cancer types. We performed whole-exome sequencing on 163 patients with metastatic solid cancers, identified 78 who had TP53 missense mutations, and through immunologic screening, identified 21 unique T-cell reactivities. Here, we report a library of 39 T-cell receptors (TCR) targeting TP53 mutations shared among 7.3% of patients with solid tumors. These TCRs recognized tumor cells in a TP53 mutation- and human leucocyte antigen (HLA)-specific manner in vitro and in vivo. Twelve patients with chemorefractory epithelial cancers were treated with ex vivo–expanded autologous tumor-infiltrating lymphocytes (TIL) that were naturally reactive against TP53 mutations. However, limited clinical responses (2 partial responses among 12 patients) were seen. These infusions contained low frequencies of mutant p53–reactive TILs that had exhausted phenotypes and showed poor persistence. We also treated one patient who had chemorefractory breast cancer with ACT comprising autologous peripheral blood lymphocytes transduced with an allogeneic HLA-A*02–restricted TCR specific for p53R175H. The infused cells exhibited an improved immunophenotype and prolonged persistence compared with TIL ACT and the patient experienced an objective tumor regression (-55%) that lasted 6 months. Collectively, these proof-of-concept data suggest that the library of TCRs targeting shared p53 neoantigens should be further evaluated for the treatment of patients with advanced human cancers.
See related Spotlight by Klebanoff, p. 919
A Novel PHD2/VHL-mediated Regulation of YAP1 Contributes to VEGF Expression and Angiogenesis
Authors: Bora-Singhal Namrata , Saha Biswarup , Mohankumar Durairaj , Padmanabhan Jaya , Coppola Domenico , Chellappan Srikumar 
Published: June 2022

The transcriptional coactivator YAP1 is the major oncogenic component of the Hippo signaling pathway and contributes to the genesis and progression of various tumors, including non–small cell lung cancer (NSCLC). YAP1 levels are regulated by the canonical Hippo kinases, MST1/2 and LATS1/2, which modulate its cytoplasmic retention and proteasomal degradation. While noncanonical regulation of YAP1 has been reported, its role in hypoxic response is not fully elucidated. The studies presented here show that YAP1 levels and function are modulated by von Hippel–Lindau (VHL) and prolyl hydroxylase 2 (PHD2). YAP1 could regulate multiple genes involved in angiogenesis through E2F1; it also associates with HIF1α in cancer cells under hypoxic conditions, inducing the VEGF-A promoter. Under normoxic conditions, PHD2 associates with and hydroxylates specific proline residues on YAP1, facilitating its interaction with VHL and promoting ubiquitination and subsequent proteasomal degradation. Exposure to hypoxia dissociates YAP1 from PHD2 and VHL, elevating YAP1 levels and enhancing its association with HIF1α. YAP1–HIF1α interaction was higher in NSCLC and renal cell carcinoma samples, indicating a role for this interaction in the genesis of these cancers. Our results thus reveal a novel mode of regulation of YAP1 by PHD2 and VHL in normoxic cells, suggesting that YAP1-mediated induction of VEGF and other genes contributes to hypoxic response in tumors.Significance:YAP1 under normoxic conditions is regulated by a novel nonclassical regulatory pathway involving PHD2-mediated prolylhydroxylation and proteasomal degradation; absence of this regulation under hypoxic conditions stabilizes YAP1, contributing to neoangiogenesis.
A perturbative approach to study information communication in brain
networks
Authors: Madan Mohan Varun , Banerjee Arpan 
Published: June 2022

Abstract
How communication among neuronal ensembles shapes functional brain dynamics is a question of fundamental importance to neuroscience. Communication in the brain can be viewed as a product of the interaction of node activities with the structural network over which these activities flow. The study of these interactions is, however, restricted by the difficulties in describing the complex dynamics of the brain. There is thus a need to develop methods to study these network-dynamical interactions and how they impact information flow, without having to ascertain dynamics a priori or resort to restrictive analytical approaches. Here, we adapt a recently established network analysis method based on perturbations, it to a neuroscientific setting to study how information flow in the brain can raise from properties of underlying structure. For proof-of-concept, we apply the approach on in silico whole-brain models. We expound on the functional implications of the distributions of metrics that capture network-dynamical interactions, termed net influence and flow. We also study the network-dynamical interactions at the level of resting-state networks. An attractive feature of this method is its simplicity, which allows a direct translation to an experimental or clinical setting, such as for identifying targets for stimulation studies or therapeutic interventions.
Choice Implies Meaning
Authors: Miller Timothy E. 
Published: June 2022

Abstract
That 1 Peter uses participles where imperatives are expected is clear. Why it does so is not. Scholarly discussion has focused on whether the participles are independent or dependent. Early grammarians argued that these participles were dependent but struggled to explain why the participles appeared far from their head verb. Modern grammarians have argued that they are independent, yet they have given insufficient attention to why the participle is used instead of the imperative. This article suggests a path forward, which vindicates the earlier interpretation by providing a discourse explanation for the “imperatival participles.” Stated simply, the participle is operating according to its normal function by structuring the discourse. That the participles in 1 Peter are far from their head verb shows the complex structuring of the letter, with the main imperatives moving the discourse along and the participles expressing ways that those head verbs may be accomplished.
Actor and partner effects of positive affect on communal coping
Authors: Horner Fiona S. , Helgeson Vicki S. 
Published: June 2022

Positive affect (PA) has been shown to facilitate the accrual of social resources which, in turn, reduces stress and improves health. These social resources may encourage interpersonal coping strategies, but this effect has been understudied. The present research examined if PA facilitates the interpersonal coping style of communal coping, defined as the perception of a stressor as shared (shared appraisal) and collaborative action to manage the stressor (collaboration). We assessed whether trait and state PA predicted increased collaboration and shared appraisal on the same day, and whether state PA predicted increased collaboration and shared appraisal the following day. Participants were romantic partners in which one person had recently been diagnosed with type 2 diabetes. Patients ( n = 198, 45% female, 44.9% Black, 72% married) and their significant others completed daily diary surveys that assessed PA, negative affect, and diabetes-specific shared appraisal and collaboration for 14 days. Multilevel modeling was used to differentiate the effects of within-person (state) and between-person (trait) PA. Actor Partner Interdependence Modeling was used to assess the effects of both couple member’s mood on one person’s coping. Results showed partner state PA was cross-sectionally linked to shared appraisal, but the link of actor PA to shared appraisal was accounted for by the inclusion of actor NA. Both actor and partner state and trait PA were cross-sectionally linked to collaboration. Importantly, actor state PA predicted next-day shared appraisal. Findings provide initial support for the role of affect in predicting communal coping.
Length of stay and influencing factors of NICU in the Western Hunan, an underdeveloped area of China: A 9-year retrospective study
Authors: Xie Fen , Shu Qingxia , Chen Zheng-Ying , Li Jinxiu 
Published: June 2022

Objective To investigate the factors that influence the length of stay (LOS) in a neonatal intensive care unit (NICU). Methods This retrospective study analysed clinical data from all newborns hospitalized in the NICU of a tertiary hospital in the Western Hunan area of China over a 9-year period (2012–2020). Factors associated with the LOS were analysed using univariate analysis and Cox regression analysis. Results A total of 16 094 newborns were included in the study: of which 9615 were inborn and 6479 were outborn newborns. There were 9482 males and 6612 females. Over the 9-year period, the mean LOS was 11.08 days (median LOS, 9.00 days; range, 1–141 days); and the LOS first increased, then decreased and stabilized. A LOS of 8–28 days was the most common duration (8849 of 16 094; 54.98%). Cox regression analysis demonstrated that sex, patient source, delivery method, gestational age, birth weight and comorbidities were significantly associated with LOS. Conclusion Being male, low gestational age and low birth weight increased the LOS. Reducing preterm and post-term infants, as well as eliminating comorbidities, could effectively shorten the LOS of newborns.