bluuebunny/crossref_metadata_2025_split huggingface dataset:
Model of Force Interaction for Stability Prediction in Turning of Thin-Walled Cylindrical Workpiece
Authors: Falta Jiří , Sulitka Matěj , Janota Miroslav , Frkal Vojtěch 
Published: June 2022

Abstract
Turning of the thin-walled cylindrical workpiece is technologically highly demanding process due to the high flexibility of the workpiece . In this paper, a mathematical treatment of integral-based model of the cutting force which takes into account feed, cutting speed, depth of cut and tool nose radius leading to a model of tool- workpiece interaction is presented. The force interaction together with the compliant workpiece dynamics leads to a machining stability formulation. The effect of the aforementioned parameters on characteristic exponents is calculated and validated by comparison with experimentally identified exponents.
One of the outputs with immediate practical value is identification of the process damping, which is in the studied case shown to be significantly higher than structural damping of the workpiece itself. This means that without loss of reliability in stability prediction the experimental modal analysis of a given workpiece may be omitted and workpiece ' dynamics may be described only by mass and stiffness matrices which can be easily and reliably obtained by a finite element analysis.
Trust Aware Secured Energy Efficient Rule based Fuzzy Clustering Protocol with modified Sun Flower optimization Algorithm in Wireless Sensor Networks
Authors: Dinesh K. , SVN Santhosh Kumar 
Published: June 2022

Abstract
Internet of Things (IoT) is a superset of Wireless Sensor Networks (WSNs). Due to its distributed nature, it can be employed across different hazardous environments. In WSNs, devices are treated as various resource factors such as computing resources, sources of energy, storage systems, and security resources, necessitating the use of robust dynamic routing protocol. In most significant breakthrough of wireless data transmission the devices are capable of transmitting data with low cost and very minimal power supply in order to enhance network lifetime and optimization of energy consumption in the network. Any intrusion to data and network security might have a real and physical impact on network quality and affects the security to the network will deployed by the sensor nodes for remote monitoring in unauthorized environment. Pertaining to the geographical location, WSNs plays a wide open role in addressing the modern day challenges all around the world. However in WSNs, the selection of the optimal path with reduced energy and providing optimized security still poses a major challenge. To address this challenge, a methodology in this work has been proposed by choosing multiple trust factors to detect the malicious node, thereby electing a efficient cluster head by using Fuzzy temporal rules with Modified Sun Flower Optimization (FMSFO) algorithm. Moreover, the proposed system produces high reliability and security by employing modified Elgamal Digital Signature algorithm for secured data transmission for the nodes of WSNs. The proposed system provides high potentiality against various types of attacks by reducing the packet loss in indentify the malicious node, resulting in a better QoS and enhance the lifetime of the sensor nodes. The proposed protocol is implemented in NS3 simulator by using realistic simulation parameters. The simulation shows that the proposed method is efficient in terms of energy efficiency, throughput, PDR ratio, delay and provides better security when it is compared with the other existing state of art systems.
Excimer Laser Coronary Angioplasty Versus Manual Aspiration Thrombectomy in Patients With ST- segment Elevation Myocardial Infarction: Analyzed by Nuclear Scintigraphy
Authors: Shimojo Kazuki , Shibata Naoki , Takagi Kensuke , Mitsuhashi Hirotsugu , Morita Yasuhiro , Kanzaki Yasunori , Watanabe Naoki , Yoshioka Naoki , Miyazawa Hiroyuki , Imaoka Takuro , Sakamoto Gaku , Ohi Takuma , Goto Hiroki , Karasawa Hoshito , Morishima Itsuro 
Published: June 2022

Abstract
Purpose: Clinical outcomes regarding the efficacy of excimer laser coronary angioplasty (ELCA) in real-world cases of acute myocardial infarction (MI) are limited. We evaluated the impact of ELCA on myocardial salvage and left ventricular (LV) systolic/diastolic function in patients with ST-segment elevation MI (STEMI) compared with manual aspiration thrombectomy using nuclear scintigraphy.Methods: We enrolled 143 consecutive STEMI patients treated with ELCA (63 patients) or manual aspiration thrombectomy (80 patients) between September 2016 and December 2020 in a single-center hospital. We checked peak creatine kinase (CK)/ creatine kinase-myocardial band (CK-MB) level and demonstrated single-photon emission computed tomography (SPECT) analyses with Quantitative Gated SPECT and Quantitative Perfusion SPECT (Auto QUANT 7.2) at 3–10 days using 123I-BMIPP and 3 months after percutaneous coronary intervention using 99mTc-tetrofosmin to evaluate myocardial salvage and LV systolic/diastolic function. Results: There was no significant difference in patients’ and periprocedural characteristics. Peak CK-MB level was significantly different between the groups (ELCA group, 190.0 [70.5–342.0] IU/L vs. aspiration group, 256.5 [157.0–354.8] IU/L, p=0.047). Although there was no significant difference in myocardial salvage, significant improvement in the LV ejection fraction (14.1 [6.2-19.8]% vs. 9.5 [3.9-15.3]%, respectively, p=0.017) and peak emptying rate (-0.54 [-1.02–-0.27] mL/s vs. -0.38 [-0.76–-0.05] mL/s, respectively, p=0.017) were detected.Conclusion: ELCA could suppress myocardial deviation enzymes and potentially improve systolic function in STEMI patients compared to manual aspiration thrombectomy.
Multidrug resistance genes screening of pancreatic cancer based on sensitivity profile to chemotherapeutic drugs
Authors: Zhao Bangbo , Qin Cheng , Li Zeru , Wang Yuanyang , Li Tianhao , Cao Hongtao , Yang Xiaoying , Li Tianyu , Wang Weibin 
Published: June 2022

Abstract
Backgrounds Pancreatic cancer (PC) is one of the most lethal cancer types and chemotherapeutic drug resistance is a stumbling block in improving the overall survival of PC patients. The nature of specific drug resistant subpopulation within pancreatic cancer is believed to be partly attributed to epithelial-mesenchymal transition (EMT) and cell stemness. Various PC cell lines show various degrees of resistance to chemotherapeutic agents including gemcitabine (GEM) and 5-fluorouracil (5-FU). In-depth understanding of drug resistance mechanisms and profile heterogeneities could lead to the development of novel and precise therapeutic strategies for addressing the chemo-resistant dilemma in PC patients. Methods Cytotoxicity assays were performed by CCK8 in ten common PC cell lines including AsPC-1, BxPC-3, Capan-1, CFPAC, HPAFII, MIA PaCa-2, PANC-1, Patu-8988, SW1990 and T3M4. RNA-seq data of the ten cell lines were downloaded from Cancer Cell Line Encyclopedia (CCLE) database and subsequently analyzed for differentially expressed genes (DEGs). Based on first-line chemotherapy regimens of pancreatic cancer, intersections were taken among the DEGs of the five drugs and the expression level of genes in the intersections between resistant and sensitive cell lines were validated by qRT-PCR. Enriched pathways of differentially expressed genes between the resistant and sensitive cell lines were acquired by Metascape database.Results We found that the top two toxic drugs for PC cell lines were paclitaxel and gemcitabine. Among the ten PC cell lines, SW1990 was the most resistant PC cell line with the highest IC50 levels for three drugs, while MIA PaCa-2 and BxPC-3 were the most sensitive PC cell lines. Differential expression analysis revealed the highest number of DEGs associated with cisplatin sensitivity up to 642 genes, of which 181 genes were upregulated and 461 genes were downregulated in cisplatin-resistant cell lines. The least number of DEGs are associated with gemcitabine sensitivity, of which 37 genes were highly expressed in gemcitabine-resistant PC cell lines and 25 genes were lowly expressed. Enrichment analysis of the DEGs revealed that pathways associated with drug resistance were mainly extracellular matrix and cell-cell junction related pathways.Conclusions PC cell lines showed diverse sensitivities to commonly used chemotherapeutic agents, which was caused by differential gene expression between the resistant and sensitive cell lines. The heterogeneity and its associated genes were enriched in extracellular matrix and cell-cell junction related pathways. Our study first portrayed the sensitivity profile to chemotherapeutic drugs of PC, which would benefit the chemoresistance mechanism study by reemphasizing the vital role of extracellular matrix and cell-cell junction related pathways and helping the selection of suitable PC cell lines.
Assessment of HRQoL and its Determinants for Kidney Stone Formers in urological settings of Pakistan
Authors: Ali Zulnorain , Khan Ahmad , Mehmood Tahir , Malik Obaidullah , Khan Jallat , el-emir zein 
Published: June 2022

Abstract
BackgroundQuality of life is the central health-improving goal. Urolithiasis is a complex disease related to disease-related morbidity and consequently effecting patient’s health-related quality of life (HRQoL). The study aims to evaluate the HRQoL and markers of HRQoL of kidney stone formers using a disease-specific instrument. Methods HRQoL of kidney stone formers were compared with healthy individuals using Wisconsin stone quality of life (WISQoL) questionnaire. A prospective, cross-sectional, case-control study was conducted at different urological settings of Rawalpindi, Pakistan. Result Multivariate analysis of variance (MANOVA) analysis depicted that compared with healthy individuals stone formers reported statistically significant (p < 0.001) differences in HRQoL in overall health and all the four domains of WISQoL i.e., social, emotional, disease impact and impact on vitality. Regression analysis evaluated that demographic factors, clinical features of the disease and surgical procedure for active removal of stone are major determinants of QoL for stone formers (p<0.05).Conclusion It was concluded that urolithiasis, its various disease related characteristics along with its management choices, is compromising patient’s quality of life in all major domains of health. WISQoL questionnaire was proved to be a reliable disease-specific instrument for the assessment of HRQoL of kidney stone patients.
An Extensive Review on β-lactamase Enzymes and their Inhibitors
Authors: Agarwal Vidhu , Tiwari Akhilesh , Varadwaj Pritish 
Published: June 2022

Abstract:
β-lactam antibiotics treat bacterial infections very effectively, but overuse and misuse have led to resistance. β-lactamase enzymes hydrolyze β-lactam antibiotics and are the primary cause of resistance in bacteria. Bacteria evolve and clinically mutate to produce such β-lactamase enzymes, which could hydrolyze newly discovered antibiotics. Therefore, carbapenems are considered to be the last resort of antimicrobial treatment. Further, different inhibitors have been discovered to fight these evolving and mutating β-lactamase enzymes resistance. These inhibitors are given in combination with the β-lactam antibiotics to treat bacterial infections effectively. But in due course of time, it has been observed that bacteria develop resistance against this combination. This is an extensive review, which discusses different classes of β-lactamase enzymes, their mechanism of action, and the role of critical structural elements like loops and catalytically relevant mutations. Such mutations and structural modifications result in expanding the spectrum of activity, making these β-lactamase enzymes resistant to the newly discovered β-lactam antibiotics and their inhibitors. Detailed knowledge of such mutations, catalytically relevant structural modifications, related kinetics, and action mechanisms could help develop new inhibitors effectively. Further, a detailed discussion of available inhibitors against each class of β-lactamase enzymes is also present.
Iodine(III)-Mediate Oxidative Cyanation, Azidation, Nitration, Sulfenylation and
Slenization in Olefins and Aromatic Systems
Authors: Segura-Quezada Luis A. , Torres-Carbajal Karina R. , Juárez-Ornelas Kevin A. , Navarro-Santos Pedro , Granados-López Angélica J. , González-García Gerardo , Ortiz-Alvarado Rafael , de León-Solis Claudia , Solorio-Alvarado César R. 
Published: June 2022

Abstract:
Iodine(III) reagents represent nowadays a class of highly relevant oxidants in organic
synthesis which possess important properties such as safer, non-toxic, green and easy to
handle compounds. These characteristics, in several cases, make them important alternatives
to the procedures which use hazardous and strong reaction conditions. Based upon their ability
as oxidants, they have been exploited in the functionalization of the different aromatic nuclei,
allowing the introduction of several groups: among them, inorganic functionalities. Herein, the
most relevant developed protocols for functionalizing a broad amount of aryls, heteroaryls and
olefins are summarized by introducing the inorganic groups cyano, azido, nitro, sulfur and
selenium, using different iodine(III) reagents.
Vascular Lesions and Brain Atrophy in Alzheimer’s, Vascular and Mixed
Dementia: An Optimized 3T MRI Protocol Reveals Distinctive Radiological
Profiles
Authors: Ramusino Matteo Cotta , Vitali Paolo , Anzalone Nicoletta , Melazzini Luca , Lombardo Francesca Paola , Farina Lisa Maria , Bernini Sara , Costa Alfredo 
Published: June 2022

Background:
Vascular lesions may be a common finding also in Alzheimer's dementia,
but their role on cognitive status is uncertain.

Objective:
The study aims to investigate their distribution in patients with Alzheimer's, vascular or
mixed dementia and detect any distinctive neuroradiological profiles.

Methods:
Seventy-six subjects received a diagnosis of Alzheimer’s (AD=32), vascular (VD=26) and
mixed (MD=18) dementia. Three independent raters assessed the brain images acquired with an optimized
3T MRI protocol (including (3D FLAIR, T1, SWI, and 2D coronal T2 sequences) using semiquantitative
scales for vascular lesions (periventricular lesions (PVL), deep white matter lesions
(DWML), deep grey matter lesions (DGML), enlarged perivascular spaces (PVS), and microbleeds
(MB)) and brain atrophy (medial temporal atrophy (MTA), posterior atrophy (PA), global cortical atrophy-
frontal (GCA-F) and Evans’ index).

Results:
Raters reached a good-to-excellent agreement for all scales (ICC ranging from 0.78-0.96). A
greater number of PVL (p<0.001), DWML (p<0.001), DGML (p=0.010), and PVS (p=0.001) was observed
in VD compared to AD, while MD showed a significant greater number of PVL (p=0.001),
DWML (p=0.002), DGML (p=0.018), and deep and juxtacortical MB (p=0.006 and p<0.001, respectively).
Comparing VD and MD, VD showed a higher number of PVS in basal ganglia and centrum
semiovale (p=0.040), while MD showed more deep and juxtacortical MB (p=0.042 and p=0.022, respectively).
No significant difference was observed in scores of cortical atrophy scales and Evans’ index
among the three groups.

Conclusion:
The proposed MRI protocol represents a useful advancement in the diagnostic assessment
of patients with cognitive impairment by more accurately detecting vascular lesions, mainly microbleeds,
without a significant increase in time and resource expenditure. Our findings confirm that
white and grey matter lesions predominate in vascular and mixed dementia, whereas deep and juxtacortical
microbleeds predominate in mixed dementia, suggesting that cerebral amyloid angiopathy
could be the main underlying pathology.
Diet and Sudden Death: How to Reduce the Risk
Authors: Manolis Antonis S. , Manolis Theodora A. , Manolis Antonis A. , Melita Helen 
Published: June 2022

Abstract:
In addition to the association of dietary patterns, specific foods and nutrients with several
diseases, including cardiovascular disease and mortality, there is also strong emerging evidence of an
association of dietary patterns with the risk of sudden cardiac death (SCD). In this comprehensive review,
data are presented and analyzed about foods and diets that mitigate the risk of ventricular arrhythmias
(VAs) and SCD, but also about arrhythmogenic nutritional elements and patterns that seem to
enhance or facilitate potentially malignant VAs and SCD. The antiarrhythmic or protective group comprises
fish, nuts and other foods enriched in omega-3 polyunsaturated fatty acids, the Mediterranean and
other healthy diets, vitamins E, A and D and certain minerals (magnesium, potassium, selenium). The
arrhythmogenic-food group includes saturated fat, trans fats, ketogenic and liquid protein diets, the
Southern and other unhealthy diets, energy drinks and excessive caffeine intake, as well as heavy alcohol
drinking. Relevant antiarrhythmic mechanisms include modification of cell membrane structure by
n-3 polyunsaturated fatty acids, their direct effect on calcium channels and cardiomyocytes and their
important role in eicosanoid metabolism, enhancing myocyte electric stability, reducing vulnerability to
VAs, lowering heart rate, and improving heart rate variability, each of which is a risk factor for SCD.
Contrarily, saturated fat causes calcium handling abnormalities and calcium overload in cardiomyocytes,
while a high-fat diet causes mitochondrial dysfunction that dysregulates a variety of ion channels
promoting VAs and SCD. Free fatty acids have been considered proarrhythmic and implicated in facilitating
SCD; thus, diets increasing free fatty acids, e.g., ketogenic diets, should be discouraged and replaced
with diets enriched with polyunsaturated fatty acids, which can also reduce free fatty acids. All
available relevant data on this important topic are herein reviewed, large studies and meta-analyses and
pertinent advisories are tabulated, while protective (antiarrhythmic) and arrhythmogenic specific diet
constituents are pictorially illustrated.
Elucidating the Molecular Targets and Mechanisms of Chlorogenic Acid
Against Alzheimer’s Disease via Network Pharmacology and Molecular
Docking
Authors: Liu Xinxin , Wang Yabo 
Published: June 2022

Background:
Chlorogenic acid (CGA), a polyphenolic substance extracted from many traditional
Chinese medicines, exerts a mitigative effect in dementia, including Alzheimer’s disease (AD).
However, the pathological mechanisms of CGA against AD remain obscure.

Objective:
To elucidate the core targets, functional characteristics, and underlying mechanisms of CGA
against AD using network pharmacology approaches and molecular docking technologies.

Methods:
GEO database was used to identify the differentially expressed genes (DEGs) in AD. PharmMpper,
TargetNet, and SwissTargetPrediction predicted the CGA-related targets. STRING and Cytoscape
were employed to construct and analyze the PPI network. Moreover, the Metascape platform was
used to perform the GO biological processes and KEGG pathways enrichment. Molecular docking was
performed using Autodock Vina software.

Results:
A total of 5437 targets related to AD were identified with |log2Fold Change (FC)| ≥ 1 and P <
0.05. Based on public databases, 193 putative target genes of CGA were screened. Using the Venn diagram,
we found 137 co-targets between CGA and AD. According to the PPI network, 23 core targets for
CGA to treat AD were obtained. KEGG enrichment displayed that the PI3K-Akt signaling pathway,
MAPK signaling pathway, apoptosis, and NOD-like receptor signaling pathway were several important
signaling pathways involved in CGA against AD. SRC, EGFR, HSP90AA1, MAPK1, RHOA, and
PIK3R1 were hub targets associated with the activities of CGA against AD. Molecular docking analysis
revealed a good binding affinity between CGA and these targets through hydrogen bonds.

Conclusion:
CGA might exert therapeutic effects in AD by regulating multiple targets and signaling
pathways. However, further in vitro and in vivo experiments are required to thoroughly confirm the detailed
targets and mechanisms of CGA against AD.
Association between Red Blood Cell Distribution Width and Pulmonary
Function among Iranian Employees
Authors: Pouryaghoub Gholamreza , Pouragha Hamidreza , Ardali Tayebeh Nasiri , Mehrdad Ramin 
Published: June 2022

Background:
RDW has been proposed as a routine test and is available as a prognosis for many diseases and disorders, especially respiratory disorders. In this study, we intend to see if the association between pulmonary function and RDW also applies to non-patients.

Methods:
This study was performed on 800 people including 466 women and 344 men. Participants in the study were staff enrolled in the Tehran University of Medical Sciences cohort [TEC] study. In this study, RDW levels and pulmonary function were assessed. Elderly populations were not in-cluded in this study.

Results:
The results of the univariate analysis showed that normal values versus abnormal values of RDW were significantly associated with pulmonary function index FEV1, FVC, FEV1/FVC in non-patient individuals. On the other hand, a significant correlation was observed between RDW values and FEV1 index and FEV1/FVC ratio. Based on linear regression, there was an association between RDW and FVC [R2=0.721].

Conclusion:
In this study, we found an association between RDW and FVC so we suggest that ab-normal RDW may be considered as a sign of pulmonary dysfunction.
Predictors of Preconception Care Reception in a Sample of Iranian Pregnant
Women Referred to Qazvin Health Centers
Authors: Bahrami Nasim , Allen Kelly-Ann , Alimoardi Zainab 
Published: June 2022

Background:
Preconception care (PCC) is one of the most important components of healthcare services for women of reproductive age. Focus on improving preconception health; it can lead to improved reproductive outcomes, healthier pregnancies, and healthier babies.

Aim:
Determine the predictive factors of receiving PCC in pregnant women of Qazvin.

Methods:
The present cross-sectional study was conducted from March 2018 to September 2019. Participants were 350 pregnant women in their 6-14 weeks of gestation, who had been referred to a selected comprehensive health center (CHC) for their initial prenatal visits. A two-stage cluster sampling was used to access the samples with maximum socioeconomic and cultural diversity. Data was collected using a questionnaire about demographics, fertility, and factors that affect access to PCC; a questionnaire about perceived social support; and a general self-efficacy questionnaire. Data was analyzed using univariate and multivariate logistic regression methods with SPSS software version 25.

Results:
In the present study, 57.5% of the participants had received PCC. More than 75% of them received this care less than a year ago at a CHC. In the final model, wanted pregnancy (OR= 11.68), awareness of PCC (OR= 8.86) and history of ART for current pregnancy (OR= 7.18) were the strongest predictors in the model.

Conclusion:
Women of reproductive age appear to benefit strongly from PCC services, when they have planned their pregnancy and were aware of PCC service. Therefore, information related to the opportunities and potential outcomes of PCC should be made publically available. In addition, healthcare providers should focus more on providing patients with information about preconception counseling.