bluuebunny/crossref_metadata_2025_split huggingface dataset:
Arsenic immobilization in soil affected by mining waste using waste‐derived functional hydrochar and iron‐encapsulated materials
Authors: Haris Muhammad , Netherway Pacian , Eshtiaghi Nicky , Paz‐Ferreiro Jorge 
Published: November 2022

AbstractArsenic (As) contamination is a widespread problem. Continued and concerted effort in exploring sustainable remediation strategies is required, with in situ immobilization emerging as a promising option. This work valorized a waste by‐product from olive (Olea europaea L.) milling into functional hydrochar (HC). The HC was then transformed into iron oxide–encapsulated carbon with three different iron loading rates (10, 25, and 50% w/w of iron chloride hexahydrate added to the olive mill waste feedstock). The HC and the three iron oxide–encapsulated carbon materials were then tested in a pot trial using a 3% w/w application rate as a means to immobilize As in a mining‐contaminated soil (2,580 ± 110 mg kg−1 As). After a 45‐d incubation period, the effect of adding the amendments on As mobility and bioaccessibility compared with an untreated control was measured using a sequential extraction procedure and in vitro bioaccessibility, respectively. All four treatments resulted in a decrease in mobility and in vitro bioaccessibility as compared with the control. Specifically, As in the mobile phases was up to 35% less than the in control, whereas bioaccessibility was 21.8% in the control and ranged from 17.5 to 12.3% in the treatments. The efficiency of amendments to immobilize As increased with the iron content of the developed materials. This work positions HCs and iron oxide–encapsulated carbon materials produced from olive mill waste as promising options to immobilize As in situ.
Characteristics and prognosis of distant metastasis after primary treatment for early‐stage extranodal nasal‐type natural killer/T‐cell lymphoma from the China Lymphoma Collaborative Group database
Authors: Zheng Xuan , Qu Bao‐Lin , Liu Xin , Zhong Qiu‐Zi , Qian Li‐Ting , Yang Yong , Hou Xiao‐Rong , Qiao Xue‐Ying , Wang Hua , Zhu Yuan , Cao Jian‐Zhong , Wu Jun‐Xin , Wu Tao , Zhu Su‐Yu , Shi Mei , Zhang Hui‐Lai , Zhang Xi‐Mei , Su Hang , Song Yu‐Qin , Zhu Jun , Zhang Yu‐Jing , Huang Hui‐Qiang , Wang Ying , Chen Fan , Yin Lin , He Xia , Zhang Li‐Ling , Li Ye‐Xiong , Qi Shu‐Nan 
Published: November 2022

AbstractThis study aimed to investigate the characteristics and prognosis of distant metastasis (DM) after primary treatment for early‐stage extranodal nasal‐type natural killer (NK)/T‐cell lymphoma (ENKTCL). A total of 1619 patients from the China Lymphoma Collaborative Group database were retrospectively reviewed. The cumulative incidence of DM was assessed using Fine and Gray's competing risk analysis. The correlation between DM sites was evaluated using phi coefficients, while DM sites were classified using hierarchical clustering. Regression analysis was used to assess the linear correlation between DM‐free survival (DMFS) and overall survival (OS). The 5‐year cumulative DM rate was 26.2%, with the highest annual hazard rate being in the first year (14.9%). The most frequent DM sites were the skin and soft tissues (SSTs, 32.4%) and distant lymph nodes (LNs, 31.3%). DM sites were categorized into four subgroups of distinct prognosis — distant LN, SST, extracutaneous site, and lymphoma‐associated hemophagocytic lymphohistiocytosis. SST or distant LN, solitary metastasis, and late‐onset DM demonstrated a relatively favorable prognosis. Contemporary chemotherapy significantly decreased DM rates and improved DMFS. Decreased DM rates were further associated with increased OS probabilities. Our findings improve the understanding of the variable clinical behaviors of early‐stage ENKTCL based on four distinct DM sites and thus provide guidance for future therapeutic decisions, metastatic surveillance, and translational trial design.
Investigating and modeling positron emission tomography factors associated with large cell transformation from low‐grade lymphomas
Authors: Obeid Jean‐Pierre , Hiniker Susan M. , Schroers‐Martin Joseph , Guo H. Henry , No Hyunsoo Joshua , Moding Everett J. , Advani Ranjana H. , Alizadeh Ash A. , Hoppe Richard T. , Binkley Michael S. 
Published: November 2022

AbstractLow‐grade lymphomas have a 1%–3% annual risk of transformation to a high‐grade histology, and prognostic factors remain undefined. We set to investigate the role of positron emission tomography (PET) metrics in identification of transformation in a retrospective case‐control series of patients matched by histology and follow‐up time. We measured PET parameters including maximum standard uptake value (SUV‐max) and total lesion glycolysis (TLG), and developed a PET feature and lactate dehydrogenase (LDH)‐based model to identify transformation status within discovery and validation cohorts. For our discovery cohort, we identified 53 patients with transformation and 53 controls with a similar distribution of follicular lymphoma (FL). Time to transformation and control follow‐up time was similar. We observed a significant incremental increase in SUV‐max and TLG between control, pretransformation and post‐transformation groups (P < 0.05). By multivariable analysis, we identified a significant interaction between SUV‐max and TLG such that SUV‐max had highest significance for low volume cases (P = 0.04). We developed a scoring model incorporating SUV‐max, TLG, and serum LDH with improved identification of transformation (area under the curve [AUC] = 0.91). Our model performed similarly for our validation cohort of 23 patients (AUC = 0.90). With external and prospective validation, our scoring model may provide a specific and noninvasive tool for risk stratification for patients with low‐grade lymphoma.
New mouse models with hypomorphic SUMF1 variants mimic attenuated forms of multiple sulfatase deficiency
Authors: Sorrentino Nicolina Cristina , Presa Maximiliano , Attanasio Sergio , Cacace Vincenzo , Sofia Martina , Zuberi Aamir , Ryan Jennifer , Ray Somdatta , Petkovic Igor , Radhakrishnan Karthikeyan , Schlotawa Lars , Ballabio Andrea , Lutz Cathleen , Brunetti‐Pierri Nicola 
Published: November 2022

AbstractMultiple sulfatase deficiency (MSD) is an ultrarare lysosomal storage disorder due to deficiency of all known sulfatases. MSD is caused by mutations in the Sulfatase Modifying Factor 1 (SUMF1) gene encoding the enzyme responsible for the post‐translational modification and activation of all sulfatases. Most MSD patients carry hypomorph SUMF1 variants resulting in variable degrees of residual sulfatase activities. In contrast, Sumf1 null mice with complete deficiency in all sulfatase enzyme activities, have very short lifespan with significant pre‐wean lethality, owing to a challenging preclinical model. To overcome this limitation, we genetically engineered and characterized in mice two commonly identified patient‐based SUMF1 pathogenic variants, namely p.Ser153Pro and p.Ala277Val. These pathogenic missense variants correspond to variants detected in patients with attenuated MSD presenting with partial‐enzyme deficiency and relatively less severe disease. These novel MSD mouse models have a longer lifespan and show biochemical and pathological abnormalities observed in humans. In conclusion, mice harboring the p.Ser153Pro or the p.Ala277Val variant mimic the attenuated MSD and are attractive preclinical models for investigation of pathogenesis and treatments for MSD.
Relationship between MAN2B1 genotype/subcellular localization subgroups, antidrug antibody detection, and long‐term velmanase alfa treatment outcomes in patients with alpha‐mannosidosis
Authors: Borgwardt Line Gutte , Ceravolo Ferdinando , Zardi Giulia , Ballabeni Andrea , Lund Allan Meldgaard 
Published: November 2022

AbstractAlpha‐mannosidosis (AM), an autosomal recessive disorder caused by pathogenic biallelic variants in the MAN2B1 gene, leads to lysosomal alpha‐mannosidase deficiency and accumulation of mannose‐rich oligosaccharides. Velmanase alfa (VA), a recombinant human lysosomal alpha‐mannosidase, is the first enzyme replacement therapy for non‐neurological symptoms of AM. Previously, a potential relationship was identified between three MAN2B1 genotype/subcellular localization subgroups (G1, G2, and G3) and AM disease severity. In VA‐treated patients with AM, it is unknown if a relationship exists between MAN2B1 genotype/subcellular localization subgroups, antidrug antibodies (ADAs), and infusion‐related reactions (IRRs). This pooled analysis evaluated data from 33 VA‐treated patients with AM to investigate this relationship. Overall, 10 patients were positive for ADAs, 4 of whom had treatment‐emergent ADAs (G1: 3/7 [43%]; G2: 1/17 [6%]; G3: 0/9). Treatment‐emergent ADA‐positive patients with relatively high titers (n = 2; G1: 1012 U/ml and G2: 440 U/ml) experienced mild/moderate IRRs that were well‐managed; patients with lower titers (n = 2) experienced no IRRs. Overall, changes from baseline in serum oligosaccharides and immunoglobulin G levels did not vary between ADA‐positive and ADA‐negative patients, suggesting a similar effect of VA treatment regardless of ADA status in most patients. Clinical outcomes (3MSCT and 6MWT) were also similar in most patients regardless of ADA status. While further studies are needed, these data suggest a relationship between MAN2B1 genotype/subcellular localization subgroups and ADA development, with G1 and G2 subgroups more likely to develop ADAs and IRRs. Regardless, this study suggests that ADAs have limited effect on the clinical impact of VA in most patients with AM.
Model‐Free and Model‐based Parameters Derived From CAIPIRINHA‐Dixon‐TWIST‐VIBE DCE‐MRI: Associations With Prognostic Factors and Molecular Subtypes of Invasive Ductal Breast Cancer
Authors: Xie Tianwen , Jiang Tingting , Zhao Qiufeng , Fu Caixia , Nickel Marcel Dominik , Peng Weijun , Gu Yajia 
Published: November 2022

BackgroundCAIPIRINHA‐Dixon‐TWIST‐VIBE (CDTV) dynamic contrast‐enhanced MRI (DCE‐MRI) can be used to characterize breast cancer. However, the influence of the clinicopathologic factors and molecular subtypes of invasive breast carcinoma (IDC) on the model‐free and model‐based parameters has not been investigated.PurposeTo compare model‐free and model‐based parameters of CDTV DCE‐MRI with both clinicopathologic factors and molecular subtypes of IDC.Study TypeProspective.PopulationA total of 152 patients (mean age, 52 years) with IDC including 42 luminal A, 64 luminal B, 22 human epidermal growth factor receptor‐2 (HER2) positive, and 24 triple‐negative subtypes.Field Strength/SequenceA 3 T; turbo‐FLASH, Dixon VIBE, and CDTV.AssessmentModel‐free parameters (initial enhancement rate [IER] and maximum slope [MS]) were estimated from the time‐intensity curve. The mean, minimum, maximum, and range between the minimum and maximum values of inline model‐based parameters (Ktrans, kep, and ve) were measured to assess intratumoral heterogeneity of IDC lesions.Statistical TestsStudent's t tests, Mann–Whitney U tests, Kruskal–Wallis tests, post hoc Steel‐Dwass tests, and receiver operating characteristic (ROC) curves. P < 0.05 was considered significant.ResultsNo significant differences in IER and MS values were seen among the clinicopathologic factors and molecular subtypes (Bonferroni‐corrected P = 0.011–0.862, P = 0.145–0.601, respectively). The minimum kep values in HER2‐positive IDC were significantly lower than those in HER2‐negative IDC. The mean and range kep values were independent predictors for distinguishing the high (grade 3) and low (grade 1 or 2) nuclear grade groups according to multivariable analyses. The post hoc test showed that the kep minimum and kep range values were significantly different between luminal A and HER2‐positive tumor subtypes, yielding an area‐under‐the‐curve of 0.820.Data ConclusionCompared with the model‐free parameters, inline kep related model‐based parameters on CDTV DCE‐MRI can be applied as a feasible tool to differentiate luminal A from HER2‐positive breast cancers.Evidence Level2.Technical EfficacyStage 2.
Experiences of embedding gender and sexuality diversity workshops in an undergraduate medical imaging curriculum
Authors: Starkey Deborah , Van Leent Lisa , Singh Ajesh 
Published: November 2022

AbstractThis commentary describes some of the reported challenges of health participation for the gender‐ and sexuality‐diverse (GSD) population, particularly related to medical imaging practice. The approach and student feedback of an undergraduate education initiative to support students in the delivery of culturally competent care are described. The experiences of delivery over a three‐year period are reported, including the 2020 online delivery due to COVID‐19 precautions. Student feedback demonstrates positive outcomes from the workshops and activities.
Characterization of two excipient interaction degradation products in oseltamivir phosphate powder for oral suspension by MS and NMR
Authors: Yao Beiyang , Guo Yiqun , Xie Qifeng , Jiang Manhua , Sun Fuzhou , Zhao Yanping , Tan Guoying , Sun Jiaxiang , Huang Fangfang , Song Xuezhi , You Jinsong 
Published: November 2022

AbstractOseltamivir phosphate is widely used to treat and prevent influenza, and is available in the form of capsules, powder for oral suspension, pediatric solutions, and granules. Because of the amino group, oseltamivir is easy to react with the excipients of the formulation to generate drug‐excipient interaction impurities. In this research, two degradation products in a commercial oseltamivir phosphate powder for oral suspension due to interaction between API and citrate were investigated. They were characterized to be 3‐((−6‐acetamido‐3‐(ethoxycarbonyl)‐5‐(pentan‐3‐yloxy)cyclohex‐3‐en‐1‐yl)carbamoyl)‐3‐hydroxypentanedioic acid and 2‐(2‐((−6‐acetamido‐3‐(ethoxycarbonyl)‐5‐(pentan‐3‐yloxy)cyclohex‐3‐en‐1‐yl)amino)‐2‐oxoethyl)‐2‐hydroxysuccinic acid by MS and NMR, respectively. Furthermore, the formation mechanisms of these impurities were verified, and the method of analysis of covariance was used to assess the rate of impurities' degradation.Highlights

Two excipient interaction degradation products in commercial oseltamivir phosphate powder for oral suspension were studied and elucidated in detail via LC–MS/MS and NMR.
The incompatibility risk of pH conditioners such as citrate and citric acid with formulations that contain an amino group was disclosed in this article.
Analysis of covariance was demonstrated to assess the impact of various formulations and preparation techniques on the rate of impurity degradation.
Human endogenous retroviruses in cancer: Oncogenesis mechanisms and clinical implications
Authors: Kitsou Konstantina , Lagiou Pagona , Magiorkinis Gkikas 
Published: November 2022

AbstractHuman Endogenous Retroviruses (HERVs) are viral sequences integrated into the human genome, resulting from the infection of human germ‐line cells by ancient exogenous retroviruses. Despite losing their replication and retrotransposition abilities, HERVs appear to have been co‐opted in human physiological functions while their aberrant expression is linked to human disease. The role of HERVs in multiple malignancies has been demonstrated, however, the extent to which HERV activation and expression participate in the development of cancer is not yet fully comprehended. In this review article, we discuss the presumed role of HERVs in carcinogenesis and their promising diagnostic and prognostic implications. Additionally, we explore recent data on the HERVs in cancer therapeutics, either through the manipulation of their expression, to induce antitumor innate immunity responses or as cancer immunotherapy targets. Finally, more precise and higher resolution high‐throughput sequencing approaches will further elucidate HERV participation in human physiological and pathological processes.
Batten disease through different in vivo and in vitro models: A review
Authors: Nittari Giulio , Tomassoni Daniele , Roy Proshanta , Martinelli Ilenia , Tayebati Seyed Khosrow , Amenta Francesco 
Published: November 2022

AbstractBatten disease consists of a family of primarily autosomal recessive, progressive neuropediatric disorders, also known as neuronal ceroid lipofuscinoses (NCLs). These pathologies are characterized by seizures and visual, cognitive and motor decline, and premature death. The pathophysiology of this rare disease is still unclear despite the years of trials and financial aids. This paper has reviewed advantages and limits of in vivo and in vitro models of Batten disease from murine and larger animal models to primitive unicellular models, until the most recently developed patient‐derived induced pluripotent stem cells. For each model advantages, limits and applications were analyzed. The first prototypes investigated were murine models that due to their limits were replaced by larger animals. In vitro models gradually replaced animal models for practical, cost, and ethical reasons. Using induced pluripotent stem cells to study neurodegeneration is a new way of studying the disease, since they can be distinguished into differentiating elements like neurons, which are susceptible to neurodegeneration. In vivo and in vitro models have contributed to clarifying to some extent the pathophysiology of the disease. The collection and sharing of suitable human bio samples likely through biobanks can contribute to a better understanding, prevention, and to identify possible treatment strategies of Batten disease.
The role of SST forcing in the interdecadal variations of the Pacific‐Japan pattern in the late 1990s
Authors: Li Shuping , Su Tao , Yan Pengcheng , Yang Zhaohong , Feng Guolin 
Published: November 2022

AbstractThe Pacific‐Japan (PJ) pattern is the dominant teleconnection over East Asia, closely related to the summer precipitation on various time scales. However, studies on the connection between the interdecadal variations of the PJ pattern and sea surface temperature (SST) forcing are still limited. This study indicates that the relationship between the PJ pattern and ENSO presents a pronounced interdecadal change around 1997/1998. The PJ pattern shows a baroclinic structure over the northwest Pacific and a barotropic structure near Japan during 1979–1997, while its baroclinic structure in the tropics weakens remarkably during 1998–2021, with a southward shift of its midlatitude barotropic structure. As a result, the connection between the PJ pattern and summer precipitation over East Asia exhibits an interdecadal transition in the late 1990s. In the slow La Niña decaying summer of 1979–1997, the cold SST anomalies in the tropical Indian Ocean (TIO) excite an eastward‐propagating Kelvin wave that enhances convection over the northwest Pacific, resulting in the formation of the PJ pattern. In contrast, the cold SST anomalies in the Maritime Continent rather than the TIO yield a zonally confined Kelvin wave in the rapid La Niña decaying summer of 1998–2021. The elongated Kelvin wave penetrating the central Pacific weakens convective anomalies over the northwest Pacific, thereby weakening the baroclinic structure of the PJ pattern in the tropics. Meanwhile, the warm SST anomalies in the Kuroshio Extension (KE) induce a northward shift of the East Asian subtropical westerly jet, with the anomalous anticyclonic circulation over the KE significantly affecting summer precipitation along the Meiyu belt. Therefore, the midlatitude barotropic structure of the PJ pattern shifts southward after the late 1990s.
Relating drought indices to impacts reported in newspaper articles
Authors: O'Connor Paul , Murphy Conor , Matthews Tom , Wilby Robert L. 
Published: November 2022

AbstractRelating drought indicators and real‐world impacts is fundamental for understanding and addressing drought vulnerability. We link drought indices and impacts from newspapers compiled in the Irish Drought Impacts Database (IDID) for the period 1900–2016. For three catchment clusters across the island of Ireland we link the Standardized Precipitation Index (SPI) with land‐based impacts and the Standardized Streamflow Index (SSI) with water‐based impacts by matching total reported articles per month with concurrent drought indices. Using logistic regression we find SPI‐3 links best with land‐based impact reports, whereas SSI‐2 links best with water‐based impact reports. Catchments in the east/southeast display the highest sensitivity to land‐ and water‐based impacts; however, in summer months at low deficits northwestern catchments show a higher likelihood of impact reports. In winter months the likelihood of water‐based impacts is considerably greater than the land‐based equivalent, particularly in east/southeastern catchments. Moreover, the likelihood of news‐worthy drought impacts has changed over the 117 year period. More severe deficits are required to induce a high likelihood (0.6) of land‐ and water‐based impacts in east/southeastern and southwestern catchments during 1961–2016 compared with 1900–1960. Largest changes emerge in the southwest with SPI‐3 values of −2.51 (<−3.00) required to reach the high impact likelihood threshold in the pre (post) 1961 period. Even greater reductions are found for water‐based impacts in the southwest with SSI‐2 values associated with high impact likelihoods changing from −2.04 to −2.58. Conversely, for catchments in the northwest more moderate drought deficits result in high impact likelihoods for both land‐based (from <−3.00 to −2.32 SPI‐3) and water‐based impacts (from <−3.00 to −2.29 SSI‐2) for the 1961–2016 period. These findings show the value of newspaper archives for understanding regional sensitivities to drought plus their potential for underpinning a near real‐time, drought monitoring and warning system in Ireland.
Association between total body bone mineral density and periodontitis: A Mendelian randomization study
Authors: Alayash Zoheir , Baumeister Sebastian‐Edgar , Reckelkamm Stefan Lars , Holtfreter Birte , Kocher Thomas , Baurecht Hansjörg , Ehmke Benjamin , Nolde Michael 
Published: November 2022

AbstractBackgroundThe purpose of the study was to examine the association between total body bone mineral density (BMD) and periodontitis using Mendelian randomization (MR) analysis.Methods and materialsWe used 81 single nucleotide polymorphisms (SNPs) associated with BMD at a p‐value of < 5 × 10−8 from a genome‐wide association study (GWAS) of 66,628 individuals of European descent. The GWAS for periodontitis was derived from a meta‐analysis of seven cohort studies that included 17,353 cases and 28,210 controls of European ancestry.ResultsMR showed no association between BMD and periodontitis (odds ratio per standard deviation increment in genetically predicted BMD = 1.00; 95% confidence interval: 0.92–1.08). Leave‐one‐out analyses and pleiotropy‐robust methods did not indicate any bias.ConclusionsThe MR study provided no evidence that BMD might be causally linked to periodontitis. Hence it may be concluded as the key finding that BMD depletion does not increase the risk of periodontitis.