bluuebunny/crossref_metadata_2025_split huggingface dataset:
Histone methyltransferase GLP epigenetically activates GPCPD1 to sustain cancer cell metastasis and invasion
Authors: Wen He , Shu Minghui , Chen Jia-Yi , Li Xiaofan , Zhu Qian , Zhang Jun , Tian Yuan , Lu Xiaopeng , Zhu Wei-Guo 
Published: September 2022

AbstractDisordered choline metabolism is associated with tumor progression. Glycerophosphocholine phosphodiesterase 1 (GPCPD1) is critical for cleaving glycerophosphocholine (GPC) to produce choline. However, whether and how GPCPD1 is epigenetically regulated remains largely unknown. In the current study, we report that histone H3 lysine 9 (H3K9) methyltransferase GLP (G9a-like Protein) is essential for transcriptional activation of GPCPD1 through H3K9me1 to promote tumor cell migration and invasion. Knocking down GLP or inhibiting its methyltransferase activity impaired GPCPD1 expression and decreased the choline levels. Importantly, we confirmed that both GPCPD1 and choline levels are positively correlated with cancer cell migration. The reduced migration and invasion of GPCPD1-knockdown cells were rescued by choline treatment. Interestingly, GPCPD1 gene expression was found regulated by transcription factor Krüppel-like Factor 5 (KLF5). KLF5 recruitment was GLP-dependent and was indispensable for GPC-induced GPCPD1 expression. These data suggest that GLP promotes tumor cell migration and invasion by transcriptionally activating GPCPD1. GLP and KLF5 are potential therapeutic targets in future cancer treatment.
Long-term biochar addition significantly decreases rice rhizosphere available phosphorus and its release risk to the environment
Authors: Chen Hao , Yuan Jiahui , Chen Guanglei , Zhao Xu , Wang Shenqiang , Wang Dengjun , Wang Lei , Wang Yujun , Wang Yu 
Published: September 2022

AbstractPhosphorus (P) availability, diffusion, and resupply processes can be altered by biochar addition in flooded rice rhizosphere, which controls the risk of P release to the environment. However, there are few in-situ investigations of these rhizospheric processes and effects. To explore the effects of biochar addition on soil P availability, high-resolution dialysis (HR-Peeper), diffusive gradients in thin films (DGT), and zymography techniques were used to provide direct evidence in the rice rhizosphere at the sub-millimeter scale. Long-term (9-years) field and greenhouse pot experiments demonstrated that biochar addition notably decreased the soluble/labile P and Fe concentrations in rice rhizosphere (vs. no biochar addition; CK) based on the results of Peeper, DGT, and two-dimensional imaging of labile P fluxes. DGT-induced fluxes in the soil/sediment (DIFS) model and sediment P release risk index (SPRRI) further indicated that biochar addition decreased the diffusion and resupply capacity of P from soil solid to the solution, thereby decreasing P release risk to the environment. These processes were dominated by Fe redox cycling and the hydrolysis of Al (hydro)oxides that greatly increased the unavailable P (Ca-P and residual-P). Additionally, greenhouse pot experiments (without additional biochar) showed that the previous long-term biochar addition significantly increased soil phosphatase activity, due to an adaptive-enhancing response to P decrease in the rhizosphere zone. The in-situ study on the biogeochemical reactions of P in the rice rhizosphere may provide a new and direct perspective to better evaluate the biochar addition and potential benefits to agricultural soils.
Graphical Abstract
Investigating local population dynamics of bottlenose dolphins in the northern Bahamas and the impact of hurricanes on survival
Authors: Coxon Jennifer , Arso Civil Mònica , Claridge Diane , Dunn Charlotte , Hammond Philip S. 
Published: September 2022

AbstractLittle Bahama Bank in the northern Bahamas supports several populations of bottlenose dolphins (Tursiops truncatus). We provide the first estimates of birth rate and age-class-specific apparent survival rates for the local South Abaco population using data from a long-term (1997–2014) photo-identification (photo-ID) study and use the estimated life history parameters in a population viability analysis (PVA) to predict future population trends. Hurricane events are predicted to become more intense due to climate change but knowledge of how hurricanes may impact cetacean populations is limited. Little Bahama Bank is subject to hurricane activity, so we also investigate the potential impact of hurricanes on calf, juvenile and adult survival. Photo-ID data confirmed the existence of a core adult population with relatively high site fidelity in South Abaco, but also evidence of transient animals. Estimated annual birth rate was 0.278 (95% CI: 0.241–0.337). We found strong support for a decline in apparent survival for all age-classes. Estimated survival declined by 9% in adults (0.941 in 1998, to 0.855 in 2013), 5% in juveniles (0.820 in 2000, to 0.767 in 2013) and 36% in calves (0.970 in 1997, to 0.606 in 2013). Evidence that survival was influenced by repeated hurricane activity leading to increased mortality and/or emigration was stronger for calves and juveniles than for adults. PVA simulations of an assumed isolated South Abaco population showed that declines would lead to extinction within decades, even under the most optimistic scenario. Future work should focus on establishing if South Abaco is part of natural source–sink metapopulation dynamics on Little Bahama Bank by assessing trends in abundance in local populations and establishing how they interact; this will be important for assessing their conservation status in a potentially increasingly changing environment.
Assessing the ethical and social concerns of artificial intelligence in neuroinformatics research: an empirical test of the European Union Assessment List for Trustworthy AI (ALTAI)
Authors: Stahl Bernd Carsten , Leach Tonii 
Published: September 2022

AbstractEthical and social concerns are a key obstacle to the adoption of artificial intelligence (AI) in the life sciences and beyond. The discussion of these issues has intensified in recent years and led to a number of approaches, tools and initiatives. Key amongst them is the idea of ex-ante impact assessments that aim to identify issues at the early stages of development. One prominent example of such ex-ante impact assessment is the European Union's (EU) Assessment list for Trustworthy AI (ALTAI). This article uses the findings of a large-scale application of the ALTAI to a large neuro-informatics project as an exemplar to demonstrate the effectiveness and limitations of the ALTAI in practice. The article shows that ex-ante impact assessment has the potential to help identify and address ethical and social issues. However, they need to be understood as part of a broader socio-technical ecosystem of AI. For ALTAI and related approaches to be useful in bio-medical research, they should be interpreted from a systems theory perspective which allows for their integration into the rich set of tools, legislation and approaches. The paper argues that ex-ante impact assessments have the best chance of being successful if seen applied in conjunction with other approaches in the context of the overall AI ecosystem.
Global Conjunctures and the Remaking of European Political History
Authors: Conrad Sebastian 
Published: September 2022

Abstract
Over the past decades, the writing of European history—in both its incarnations, as the history of Europe, and as the histories of nations in Europe—has seen fundamental transformations. Though it has been adapted in different ways, the global turn has deeply affected the historiography produced in many European countries. On the one hand, crucial watersheds of European history have been reinterpreted as part of larger configurations, and as responses to global challenges. On the other, it is now clear that Europe’s claim to unity and cohesion was reinforced, not least, by observers from without. In the late nineteenth century, in societies across Latin America, Africa, and Asia, contemporaries began to refer to a “Europe” that was less a specific location than a product of the imagination; the result less of geography or culture than of global geopolitics. What emerges, then, is an understanding of the history of the continent that places it firmly in the context of global conjunctures and repeated moments of re-territorialization.
Negative attitudes toward older adults: Subjective time to become older and “stereotype embodiment theory”-based intervention
Authors: Shimizu Yuho 
Published: September 2022

Abstract
Reducing negative attitudes toward older adults is an urgent issue. A previous study has conducted “stereotype embodiment theory”-based interventions (SET interventions) that present participants with the contents of SET and related empirical findings. I focus on the subjective time to become older (the perception of how long people feel it will be before they become old) as a mechanism for the effect of SET interventions. I make the SET intervention group and the control group in which the participants are presented with an irrelevant vignette. The data from 641 participants (M = 31.97 years) were analyzed. Consequently, the SET intervention shortened the subjective time to become older and reduced negative attitudes toward older adults. When considering SET interventions, it would be useful to focus not only on the self-interested motives to avoid age discrimination but also on the subjective time to become older.
Deportation, Diplomacy, and Defiance: New Research on Mexican Migration
Authors: Snodgrass Michael David 
Published: September 2022

This essay reviews the following works:They Should Stay There: The Story of Mexican Migration and Repatriation during the Great Depression. By Fernando Saúl Alanís Enciso. Translated by Russ Davidson. Chapel Hill: University of North Carolina Press, 2017. Pp. xxvi + 272. $29.95 paperback. ISBN: 9781469634265. (Original work published in 2007 as Que se queden allá: El gobierno de México y la repatriación de mexicanos en Estados Unidos, 1934–1940).Deported Americans: Life after Deportation to Mexico. By Beth C. Caldwell. Durham, NC: Duke University Press, 2019. Pp. xii + 248. $25.95 paperback. ISBN: 9781478003908.Outsourcing Welfare: How the Money Immigrants Send Home Contributes to Stability in Developing Countries. By Roy Germano. New York: Oxford University Press, 2018. Pp. x + 227. $33.95 hardcover. ISBN: 9780190862848.The Deportation Machine: America’s Long History of Expelling Immigrants. By Adam Goodman. Princeton, NJ: Princeton University Press, 2020. Pp. ix + 336. $19.95 paperback. ISBN: 9780691204208.Defiant Braceros: How Migrant Workers Fought for Racial, Sexual, and Political Freedom. By Mireya Loza. Chapel Hill: University of North Carolina Press, 2016. Pp. xiii +254. $29.95 paperback ISBN: 9781469629766.Risking Immeasurable Harm: Immigration Restriction and US-Mexican Diplomatic Relations, 1924–1932. By Benjamin C. Montoya. Lincoln: University of Nebraska Press, 2020. Pp. xiii + 342. $55.00 hardcover. ISBN: 9781496201294.Diplomacia migratoria: Una historia transnacional del Programa Bracero, 1947–1952. By Catherine Vézina. Mexico City: Centro de Investigación y Docencia Económicas, 2018. Pp. xi + 404. $13.99 e-book. ISBN: 9786078508082.
Modelling peptide–protein complexes: docking, simulations and machine learning
Authors: Mondal Arup , Chang Liwei , Perez Alberto 
Published: September 2022

Abstract
Peptides mediate up to 40% of protein interactions, their high specificity and ability to bind in places where small molecules cannot make them potential drug candidates. However, predicting peptide–protein complexes remains more challenging than protein–protein or protein–small molecule interactions, in part due to the high flexibility peptides have. In this review, we look at the advances in docking, molecular simulations and machine learning to tackle problems related to peptides such as predicting structures, binding affinities or even kinetics. We specifically focus on explaining the number of docking programmes and force fields used in molecular simulations, so a prospective user can have an educated guess as to why choose one modelling tool or another to address their scientific questions.
Cuba, Soviet Oil, and the Sanctions that Never Were: An Archival Investigation of Socialist Relations
Authors: Sanchez-Sibony Oscar 
Published: September 2022

AbstractIn the winter of 1968, tensions between Cuba and the Soviet Union boiled over as the Cuban leadership's mouthpiece, Granma, accused the Soviet Union of imposing oil sanctions on the island in order to subjugate it. Those accusations went on to become inscribed into the historiography of Soviet–Cuban relations. This intervention into that historiography is two-fold: on the one hand it uses recently declassified documents from the Soviet archives to show that there were no oil sanctions on Cuba, but rather a continuum of logistical and infrastructural challenges that created delays and tensions in the relations between these two socialist allies. On the other hand, the article contextualises the relationship within the capitalist institutions of exchange that in effect mediated it, finding in these not only part of the reason for the setbacks and tensions, but also a wider framework for better understanding the Soviet–Cuban economic relationship.
The bushmeat trade in northern Ghana: market dynamics, drivers of trade and implications for conservation
Authors: Sackey Hannah N.K. , McNamara James , Milner-Gulland E.J. , Ntiamoa-Baidu Yaa 
Published: September 2022

AbstractData on species trade profiles and volumes of wild animals on sale in local markets can provide useful insights into the bushmeat trade, enabling identification of priorities for management and conservation planning. We monitored bushmeat traded in three markets (Sandema, Chiana and Fumbisi) in the Upper East Region of Ghana during October 2018–October 2019. More than 80% of carcasses sold were amphibians (frogs). Species composition and volumes of bushmeat traded varied significantly across markets. Bushmeat sales were highest during the dry season (75% of total biomass traded). The bulk (60% of total biomass) traded in the local markets was transported long distances for resale in major urban markets in southern Ghana. Large-bodied species were comparatively low in number and sold almost exclusively for resale in southern markets. This study highlights the importance of frog meat as an affordable protein source for consumers and as income for traders in an economically deprived region. Seasonal fluctuations of bushmeat sales demonstrated the importance of bushmeat as part of a diversified livelihood strategy for hunters and traders. Furthermore, this study underscores the significant role that long-distance trade networks play as key drivers of the bushmeat trade in these parts of northern Ghana, and highlights the risks posed by current extraction levels for species conservation in this understudied region. Our recommendations include investigating the potential of sustainable amphibian production, improving protection of particular vulnerable species and of the protected areas in the region and exploring alternative livelihoods during the peak hunting season.
Associations of adverse and protective childhood experiences with thwarted belongingness, perceived burdensomeness, and suicide risk among sexual minority men
Authors: Moody Raymond L. , Carter Joseph A. , Talan Ali , Sizemore K. Marie , Russell Stephen T. , Rendina H. Jonathon 
Published: September 2022

AbstractBackgroundSexual minority men (SMM) experience higher suicidal ideation and suicide attempts than the general population. We examined the associations of adverse childhood experiences (ACES) and protective and compensatory childhood experiences (PACES) with suicidal ideation and suicide attempts in adulthood via thwarted belongingness and perceived burdensomeness among SMM.MethodsData are from the UNITE study, a national longitudinal cohort study of HIV-negative SMM from the 50 U.S. states and Puerto Rico. Between 2017 and 2019, participants (N = 6303) completed web-based assessments at baseline and 12-month follow-up. ACES and PACES occurring before the age of 18, and current symptoms of thwarted belongingness and perceived burdensomeness were assessed at baseline. Past-week suicidal ideation and past-year suicide attempt were assessed at follow-up.Results424 (6.7%) participants reported past-week suicidal ideation and 123 (2.0%) reported a past-year suicide attempt. The results of our multivariate model suggest that each additional adverse childhood experience was prospectively associated with 14% higher odds of past-week suicidal ideation (AOR = 1.14, 95% CI 1.09–1.19) and 19% higher odds of past-year suicide attempt (AOR = 1.19, 95% CI 1.11–1.29). Each additional protective childhood experience was prospectively associated with 15% lower odds of past-week suicidal ideation (AOR = 0.85, 95% CI 0.81–0.90) and 11% lower odds of past-year suicide attempt (AOR = 0.89, 95% CI 0.82–0.98). Perceived burdensomeness partially mediated these prospective associations.ConclusionTo reduce suicide, screening and treating perceived burdensomeness among SMM with high ACES may be warranted. PACES may decrease perceived burdensomeness and associated suicide risk.
A hybrid particle swarm optimization and recurrent dynamic neural network for multi-performance optimization of hard turning operation
Authors: Pourmostaghimi Vahid , Zadshakoyan Mohammad , Khalilpourazary Saman , Badamchizadeh Mohammad Ali 
Published: September 2022

Abstract
In the present work, a new hybrid approach combining particle swarm optimization (PSO) algorithm with recurrent dynamic neural network (RDNN), which is described as PSO-RDNN algorithm, is proposed for multi-performance optimization of machining parameters in finish turning of hardened AISI D2. The suggested optimization problem is solved using the weighted sum technique. Process parameters including cutting speed and feed rate are optimized for minimizing operation cost, maximizing tool life, and producing parts with acceptable surface roughness. Based on experimental results, two neural network models were developed for predicting tool flank wear and surface roughness during the machining process. Based on trained neural networks and structured hybrid algorithm, optimum cutting parameters were obtained. The coefficient of determination for trained neural networks was calculated as R2 = 0.9893 and R2 = 0.9879 for predicted flank wear and surface roughness, respectively, which proves the efficiency of trained neural models in real industrial applications. Furthermore, the offered methodology returns a Pareto optimality graph, which represents optimized cutting variables for several various cutting conditions.
Habitat selection and ontogeny of habitat use by juvenile Eurasian Spoonbill Platalea leucorodia revealed by GPS tracking
Authors: Rodrigues Manuela S. , Araújo Pedro M. , Silva João P. , Abad-Gómez José M. , Rodrigues Pedro C. , Ramos Jaime A. , Alves José A. 
Published: September 2022

Summary
Despite the widely recognized value of wetlands in providing vital ecosystem services, these are presently being degraded and ultimately destroyed, leading to a decrease in the biodiversity associated with these areas. Some species inextricably linked to wetlands, however, have been increasing and (re)colonizing areas across their range; a notable example being the Eurasian Spoonbill Platalea leucorodia. In this study we aimed to identify the most important habitats for juvenile spoonbills fledging from a traditional colony in Portugal, located in Ria Formosa, during the period of their life with the lowest survival rates: the first months after leaving the colony. We deployed 16 GPS/GSM tags on juveniles captured in different years (2016 to 2020) and tracked them during post-fledging dispersal and first winter (average 166.4 ± 29.2 SE days). Using Corine Land Cover data, we were able to identify which habitats were most important. Several habitats were used in variable proportions by individuals originating from the same colony, but there was a general trend towards using fewer habitats along the first months of life. Intertidal wetlands were the most used habitat, but anthropogenic habitats such as Wastewater Treatment Plants, saltpans and rice fields were identified as alternative habitats for young spoonbills, and may had contributed to the recent expansion of this species in Portugal.
From the Gilded Age to the Digital Age: The evolution of ICRC legal commentaries
Authors: Mohr Charlotte , Policinski Ellen 
Published: September 2022

AbstractLegal commentaries are a type of secondary source that provides clarity about the meaning of treaty provisions so they can be appropriately interpreted and applied by practitioners. Since 1870, the International Committee of the Red Cross (ICRC) has produced such commentaries on each successive international humanitarian law (IHL) treaty or update to an existing treaty. Over time, who drafts these commentaries and the methodology behind them has evolved, from early commentaries written by a single jurist who had participated in the drafting of the treaty to multi-authored works based on extensive research and the methodology found in the Vienna Convention on the Law of Treaties. The ICRC Commentaries have always been geared towards those tasked with applying IHL, but this audience has expanded over time, giving them a more global reach, and their reception has evolved accordingly. The most recent iteration of the ICRC Commentaries on the 1949 Geneva Conventions and their 1977 Additional Protocols is currently being produced, with some changes in methodology to guarantee that they remain a practical tool for the interpretation and application of those instruments.
Exoworkathlon: A prospective study approach for the evaluation of industrial exoskeletons
Authors: Kopp Verena , Holl Mirjam , Schalk Marco , Daub Urban , Bances Enrique , García Braulio , Schalk Ines , Siegert Jörg , Schneider Urs 
Published: September 2022

Abstract
Industrial exoskeletons have recently gained importance as ergonomic interventions for physically demanding work activities. The growing demand for exoskeletons is leading to a need for new knowledge on the effectiveness of these systems. The Exoworkathlon, as a prospective study approach, aims to assess exoskeletons in realistic use cases and to evaluate them neutrally in their entirety. For this purpose, a first set of four realistic Parcours was developed with experts from relevant industries, the German Social Accident Insurance, and the Federal Institute for Occupational Safety and Health. In addition, a set of ratings was defined to assess subjective user feedback, work quality, and objective physiological parameters. Exoworkathlon aims to bring together developers, researchers, and end-users, strengthen collaborative exchanges, and promote a platform for the prospective holistic data collection for exoskeleton evaluation. In this article, the focus is on the background and methodology of Exoworkathlon.
Predicting Flight Training Performance From the Tabular Speed	Test
Authors: Damos Diane L. , Bittner Alvah C. , Niemczyk Mary 
Published: September 2022

Abstract. This study determined the predictive validity for the number correct (COR) and the number wrong (WR) of a complex perceptual speed test at three milestones in a collegiate flight training program. Test–retest data were obtained at different intervals. COR predicted time to solo ( N = 119, r = −.15, p < .05) and time to the private pilot certificate ( N = 51, r = −.34, p < .01). WR did not correlate with any performance measure. Test–retest reliabilities averaged across 17 months were r = .604 for COR and r = .431 for WR, with p < .0001 for both. A factor analysis of the test–retest data demonstrated that WR and COR loaded on different factors, indicating that they assess different attributes.