bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sarcoidosis and sarcoidal foreign body reaction after permanent eye makeup application: Analysis by immunohistochemistry with commercially available antibodies specific to Cutibacterium acnes and Mycobacteria
Authors: Hirai Yuka , Hamada Yuko , Sasaki Shun , Suzuki Marie , Ito Yuta , Katayama Keiko , Uno Hirokazu , Nakada Tokio , Kitami Yuki , Uchida Keisuke , Eishi Yoshinobu , Sueki Hirohiko 
Published: March 2022

AbstractWe report two cases of eyebrow granulomas in patients who underwent a permanent eye makeup procedure. A rash was observed 16 months after the procedure in Case 1, and 10 years after the procedure in Case 2. Histopathologically, both patients exhibited noncaseating epithelioid cell granulomas. In Case 1, most of the black‐brown granules of the permanent makeup were not present in the granulomas but were localized in the upper dermis. In contrast, in Case 2, some of the black‐brown granules were phagocytized in the granulomas, preferentially within the giant cells. Based on systemic examinations, the patients from Cases 1 and 2 were diagnosed with sarcoidosis and sarcoidal foreign body reaction, respectively. To clarify the pathogenesis of our cases, we performed immunohistochemistry using commercially available monoclonal antibodies specific to Cutibacterium acnes, previously Propionibacterium acnes (PAB), and Mycobacteria (LAM antibody). PAB antibody results were positive in granulomas only in Case 1, and the LAM antibody results were negative in both cases. Immunohistochemical detection of C. acnes in granulomas could provide useful information for differentiating between cutaneous sarcoidosis and sarcoidal foreign body reactions.
Diagnosis, differential diagnosis and misdiagnosis of Susac syndrome
Authors: Triplett James D. , Qiu Jessica , O'Brien Billy , Gopinath Sumana , Trewin Benjamin , Spring Penelope J. , Shaffi Mohamed , Ip Jerome , Chan Fiona , Chen Luke , Wilson Ian , Muller Claire , Beadnall Heidi N. , Boggild Mike , Van der Walt Anneke , Roxburgh Richard , Seery Nabil , Kalincik Tomas , Barnett Michael H. , Parratt John D. E. , Reddel Stephen W. , Tsang Benjamin , Hardy Todd A. 
Published: March 2022

AbstractBackground and purposeSusac syndrome (SuS) is an inflammatory condition of the brain, eye and ear. Diagnosis can be challenging, and misdiagnosis is common.MethodsThis is a retrospective review of the medical records of 32 adult patients from an Australasian cohort of SuS patients.ResultsAn alternative diagnosis prior to SuS was made in 30 patients (94%) with seven patients receiving two or more diagnoses. The median time to diagnosis of SuS was 3 months (range 0.5–100 months). The commonest misdiagnoses were migraine in 10 patients (31%), cerebral vasculitis in six (19%), multiple sclerosis in five (16%) and stroke in five (16%). Twenty‐two patients were treated for alternative diagnoses, 10 of whom had further clinical manifestations prior to SuS diagnosis. At presentation seven patients (22%) met criteria for definite SuS, 19 (59%) for probable SuS and six (19%) for possible SuS. Six patients (19%) presented with brain–eye–ear involvement, 14 with brain–ear (44%), six with brain–eye (19%) and six (19%) with only brain involvement. In patients with the complete triad of symptoms the median delay to diagnosis was 3 months (range 1–9 months) compared to 5.25 months (range 0.5–100 months) for patients with encephalopathy and ocular symptoms at presentation.ConclusionsSusac syndrome patients are frequently misdiagnosed at initial presentation, despite many having symptoms or radiological features that are red flags for the diagnosis. Delayed diagnosis can lead to patient morbidity. The varied ways in which SuS can present, and clinician failure to consider or recognize SuS, appear to be the main factors leading to misdiagnosis.
Self‐adaptive‐deer hunting optimization‐based optimal weighted features and hybrid classifier for automated disease detection in plant leaves
Authors: Sahu Kalicharan , Minz Sonajharia 
Published: March 2022

AbstractThis main intention of this paper is to adopt a new disease detection model for plant leaves. The proposed model involves several steps such as pre‐processing, leaf segmentation, abnormality segmentation, feature extraction and detection. Image scaling and contrast enhancement are performed during the pre‐processing phase. Once the pre‐processing is done, the segmentation phase starts with leaf segmentation by binary thresholding method and abnormality segmentation by K‐means clustering. Further, the local binary pattern and grey‐level co‐occurrence matrix features are extracted and a dimensionality reduced technique called principle component analysis is determined. As the main novelty, the weighted feature extraction is performed, in which the weight functions are optimized by the self‐adaptive deer hunting optimization (SA‐DHOA). Another contribution of this paper is to implement a hybrid classifier for disease detection. Here, the extracted weighted features are subjected to a support vector machine, and the abnormality segmented image is subjected to convolutional neural network (CNN), which is a deep learning algorithm that can learn the features automatically. Here, the same SA‐DHOA is used to improve the performance of CNN, which is termed as SA‐DHOA‐SCNN. Finally, the performance analysis confirms the maximum success rate of the proposed model over other conventional methods.
Neglected fishery data sources as indicators of pre‐industrial ecological properties of Mediterranean swordfish (Xiphias gladius, Xiphiidae)
Authors: MacKenzie Brian R. , Addis Piero , Battaglia Pietro , Consoli Pierpaolo , Andaloro Franco , Sarà Gianluca , Nielsen Anders , Romeo Teresa 
Published: March 2022

AbstractManagement of fish populations and ecosystems suffers from data and knowledge gaps, particularly with respect to how humans and nature affect dynamics at multi‐decadal and longer time scales. However, collection of new data which indicates population or ecosystem status is slow and expensive. Here we analyse c. 110 years of neglected fishery data for an overexploited top predator, swordfish, in the Mediterranean Sea. These data are available at scales of high time–space–biological resolution (i.e., sub‐weekly, sub‐regional sea; individual weights) and allow different ecological questions to be addressed than is possible with coarsely scaled data (e.g., annually resolved total catches aggregated over large sea areas). We constructed regional indicators of population status (relative abundance, mean individual size and its variability, migration phenology) covering most of the 20th century, and pre‐dating other population datasets by 50–70 years. The length and duration of these new time series allowed detection of significant multi‐annual/decadal variations in abundance and mean weight not detectable in shorter, more recent time series. These new data and evidence of multi‐annual variability in population variables improve knowledge of Mediterranean swordfish ecology. The findings provide a new basis on which further historical data recovery and analysis of contemporary data can provide new perspectives and opportunities for quantifying vulnerability of populations to exploitation and climate change.
Hypoglycemic effect on adult zebrafish (Danio rerio) of the 3β‐6β‐16β‐trihydroxylup‐20(29)‐ene triterpene isolated from Combretum leprosum leaves in vivo and in silico approach
Authors: Coutinho Marnielle Rodrigues , da Silva Antonio Wlisses , Ferreira Maria Kueirislene Amâncio , de Lima Rebouças Emanuela , Mendes Francisco Rogênio S. , Teixeira Edson Holanda , Marinho Emanuelle Machado , Marinho Márcia Machado , Marinho Emmanuel Silva , Teixeira Alexandre Magno Rodrigues , de Menezes Jane Eire Silva Alencar , dos Santos Hélcio Silva 
Published: March 2022

AbstractDrugs used to manage type 2 diabetes mellitus cause adverse effects. Therefore, the search for new drugs as an alternative for the treatment of diabetes increases. The effect of triterpene 3β‐6β‐16β‐trihydroxylup‐20(29)‐ene isolated from the leaves of C. leprosum (CLF‐1) on sucrose‐induced hyperglycemia in adult zebrafish (Danio rerio) was evaluated. Initially, adult zebrafish (n = 6/group) underwent hyperglycemia induction by sucrose at 83.25 mM/L for 7 days by immersion. The hyperglycemic groups were treated with CLF‐1 (4, 20, and 40 mg/kg), metformin (200 mg/kg), and acarbose (300 mg/kg) for 4 days. The in silico interaction of CLF‐1, metformin, and acarbose with the enzyme maltase‐glucoamylase (CtMGAM) was investigated. CLF‐1 reduced sucrose‐induced hyperglycemia after 4 days of treatment, in addition to having better affinity energy with CtMGAM than metformin and acarbose. Thus, CLF‐1 may be a new pharmacological alternative as a hypoglycemic agent for the treatment of diabetes.
Ontario family justice in “lockdown”: Early pandemic cases and professional experience
Authors: Houston Claire , Birnbaum Rachel , Bala Nicholas , Deveau Kate 
Published: March 2022

AbstractThe COVID‐19 pandemic has profoundly affected families and children involved in Ontario's family justice system as well as family justice professionals in the province. In a span of two years, Ontario's family justice system has been fundamentally transformed, from a paper‐based, in‐person system to a paperless system in which many services, including judicial proceedings, continue to be largely delivered remotely. We report on the findings of two studies on the impact of the COVID‐19 pandemic on Ontario family justice: (1) an analysis of early pandemic court decisions; and (2) a survey of family justice professionals about their experiences during the early pandemic. We describe how the pandemic has exacerbated access to justice issues for certain groups, including families experiencing high conflict, victims of intimate partner violence, families involved in child welfare proceedings, and self‐represented litigants, while improving access to justice for others by improving efficiency and reducing legal costs. As Ontario moves past the pandemic, the family justice system will need to ensure that technological advances improve access to justice for all court‐involved families.
Soil organic matter, rather than temperature, determines the structure and functioning of subarctic decomposer communities
Authors: Robinson Sinikka I. , O’Gorman Eoin J. , Frey Beat , Hagner Marleena , Mikola Juha 
Published: March 2022

AbstractThe impacts of climate change on ecosystem structure and functioning are likely to be strongest at high latitudes due to the adaptation of biota to relatively low temperatures and nutrient levels. Soil warming is widely predicted to alter microbial, invertebrate, and plant communities, with cascading effects on ecosystem functioning, but this has largely been demonstrated over short‐term (<10 year) warming studies. Using a natural soil temperature gradient spanning 10–35°C, we examine responses of soil organisms, decomposition, nitrogen cycling, and plant biomass production to long‐term warming. We find that decomposer organisms are surprisingly resistant to chronic warming, with no responses of bacteria, fungi, or their grazers to temperature (fungivorous nematodes being an exception). Soil organic matter content instead drives spatial variation in microorganism abundances and mineral N availability. The few temperature effects that appear are more focused: root biomass and abundance of root‐feeding nematodes decrease, and nitrification increases with increasing soil temperature. Our results suggest that transient responses of decomposers and soil functioning to warming may stabilize over time following acclimation and/or adaptation, highlighting the need for long‐term, ecosystem‐scale studies that incorporate evolutionary responses to soil warming.
Autonomous and intercellular chemokine signaling elicited from mesenchymal stem cells regulates migration of undifferentiated gastric cancer cells
Authors: Okamoto Daiki , Yamauchi Natsuko , Takiguchi Gosuke , Nishita Michiru , Kakeji Yoshihiro , Minami Yasuhiro , Kamizaki Koki 
Published: March 2022

AbstractAccumulating evidence demonstrates that bone marrow (BM)‐derived mesenchymal stem cells (MSCs) play critical roles in regulating progression of various types of cancer. We have previously shown that Wnt5a‐Ror2 signaling in MSCs induces expression of CXCL16, and that CXCL16 secreted from MSCs then binds to its cognate receptor CXCR6 on the surface of an undifferentiated gastric cancer cell line MKN45 cells, eventually leading to proliferation and migration of MKN45 cells. However, it remains unclear about a possible involvement of another (other) cytokine(s) in regulating progression of gastric cancer. Here, we show that CXCL16‐CXCR6 signaling is also activated in MSCs through cell‐autonomous machinery, leading to upregulated expression of CCL5. We further show that CCR1 and CCR3, receptors of CCL5, are expressed on the surface of MKN45 cells, and that CCL5 secreted from MSCs promotes migration of MKN45 cells presumably via its binding to CCR1/CCR3. These data indicate that cell‐autonomous CXCL16‐CXCR6 signaling activated in MSCs upregulates expression of CCL5, and that subsequent activation of CCL5‐CCR1/3 signaling in MKN45 cells through intercellular machinery can promote migration of MKN45 cells. Collectively, these findings postulate the presence of orchestrated chemokine signaling emanated from MSCs to regulate progression of undifferentiated gastric cancer cells.
Extreme pathological symptom generated by Dermocystidium koi infection of common carp (Cyprinus carpio L.) in Hungary
Authors: Sellyei Boglárka , Molnár Kálmán , Cech Gábor , Varga Ádám , Székely Csaba 
Published: March 2022

AbstractDermocystidiosis in common carp (Cyprinus carpio L.) as a skin infection in the form of small, pea‐sized bulging nodules is well‐known in Hungary. Its occurrence is sporadic, and the pathogenic effect is generally moderate. Nonetheless, here we report an unusual case of the infection when a mass of dermocystid spore‐filled hyphae‐like cysts formed a large tumour‐like nodule under the skin intruding deeply in the red muscle on one side occipital region of the fish body. Histological sections showed that the tumour‐like nodule was composed of two layers, a pale peripheral part with a high mass of cysts surrounded by some cell debris of muscle cells and a dark central part with a less dense meshwork of tubular cysts which were embedded in the partially damaged red muscle tissue. No infection was found in the white muscle. Sequences of 18S rDNA of spores from the tumour‐like nodule showed a complete identity to sequences from typical bulging nodules in skin. They were also highly similar to the sequences of D. anguillae clones (99.5%–99.4%), to some samples of D. salmonis (99.7% and 99.4%), and to the Dermocystidium sp. CM‐2002 (99.4%) from European perch.
Preparation of skim milk powder tablet and finite element analysis of its pressing die
Authors: Vishwakarma Siddharth , Dalbhagat Chandrakant Genu , Mishra Hari Niwas 
Published: March 2022

AbstractThe skim milk powder (SMP) has problems of quantification and handling during milk reconstitution for tea and coffee making. To address these issues, a novel product, “SMP tablet,” was made by varying moisture content (3, 5, 10, and 15% wet basis) of SMP and compression force (625, 750, 875, 1,000, and 1,125 N) during tableting. A die containing upper, lower, and grooved punches was designed, fabricated, and analyzed with finite element method. The tetrahedral type of mesh with 1.9078–2.356 mm element size, 0.095–0.118 mm tolerance, 80,420–85,107 nodes, and 53,041–57,252 elements resulted in 40.53–68.60 MPa maximum stress and 1.9–4 minimum factor of safety advocating acceptability of design. The SMP was pressed inside die through universal testing machine in controlled manner and disintegration time (DT), tensile strength (TS), and insolubility index (ISi) of SMP tablets were evaluated. Response surface methodology showed cubic model as best fit (p < .0001 and R2 > .97) for all the responses. The numerical optimization showed 4.6% wb moisture and 1,125 N compression force favorable for good quality attributes (103.8 kPa TS; 318 s DT; 40.5 mg ISi). Further, sugar addition (10%), as a disintegrating agent, improved DT (178 s) and TS (159 kPa). The SMP tablet with sugar had 14.90 ± 0.05 mm average diameter, 5.04 ± 0.18 mm thickness, 625 ± 6 mg weight, and 3.45% weight variation with similar total soluble solids (5%) at 60°C compared with SMP. The direct consumable, no artificial additives/binders and ease in quantification are tablets' novelty comparing SMP.Practical applicationsPoor quantification and handling are the two major issues with SMP. This can be easily combated by pressing the powder and converted into tablet form. The quantity of required number of SMP tablets for milk reconstitution can be easily remembered like sugar cubes. The SMP tablets can be marketed as novel dairy products and taken directly or used in coffee and tea making. Moreover, this study will provide an insightful information to dairy industry for commercial application of SMP tablets.
Post‐event flood mapping for road networks using taxiGPSdata
Authors: Kong Xiangfu , Yang Jiawen , Qiu Jiandong , Zhang Qin , Chen Xunlai , Wang Mingjie , Jiang Shan 
Published: March 2022

AbstractDynamically updated and fine‐grained flooding maps are critical for situational awareness and decision support. However, traditional methods, such as eyewitness reports, remote sensing, and hydrology models, may fail to correspond with the rapidly changing urban hydrological environment. The presence of crowdsourced data (such as social media data) allows for timely and cost‐effective monitoring of flood hazards through collective observations; however, such data can be unreliable due to sample bias and low spatiotemporal resolution. Therefore, new measures to identify flood‐affected roads are desirable. In this study, we propose a methodology that leverages taxi GPS data to support post‐event flood mapping for the road network. This method can identify whether a significant reduction in the taxi passing rate for a road segment was related to precipitation, and automatically recognize the flood‐affected roads based on a logistic regression model. Using taxi GPS data in Shenzhen as an example, we derived the flood map of the road networks, and compared and validated the results. This study demonstrated the usefulness of taxi GPS data in generating high‐quality flood maps and the value of incorporating multiple data sources for sensing near real‐time flood in the city.
Quantitative criticalism: Guidelines for conducting transformative quantitative family science research
Authors: Curtis Michael G. , Boe Joshua L. , King V. Elizabeth , Osborne Kimberly R. 
Published: March 2022

AbstractHistorically, research has been used by systems of authority to marginalize and oppress minoritized populations. Family scientists have recently begun the work of disentangling themselves from these oppressive legacies (e. g., White supremacist, sexist, heterosexist, cisgenderist, etc.). As such, the field is at a vital crux in which there is a need to challenge prevailing quantitative methodological assumptions and practices in order to address and disrupt how statistical analyses can shape family sciences away from a social‐justice agenda. Drawing upon principles of critical social theory, critical race theory, and Black Feminist scholarship, this article elaborates on how family scientists can utilize Quantitative Criticalism, or QuantCrit, as a framework for conducting social justice‐orientated quantitative research. We conclude by illustrating how the tenets of QuantCrit can be utilized throughout the research process. It is our hope that readers will identify moments in their own scholarship in which these tenets can be applied.
Relationship of anthropometric measurements with glycated hemoglobin and 1‐h blood glucose after 50 g glucose challenge test in pregnant women: A longitudinal cohort study in Southern Thailand
Authors: Liabsuetrakul Tippawan , Sriwimol Wilaiwan , Jandee Kasemsak , Suksai Manaphat , Dyereg Jaeuddress 
Published: March 2022

AbstractAimsTo assess correlations of anthropometric measurements with glycated hemoglobin (HbA1c) and 1‐h blood glucose after a 50 g glucose challenge test during the first and late second trimesters and explore their relationships of anthropometric measurements with neonatal birth weight.MethodsA longitudinal study was conducted among pregnant Thai women with gestational age ≤14 weeks. Anthropometric measurements, using body mass index, body compositions, and circumferences, and skinfold thickness, were measured at four‐time points: ≤14, 18–22, 24–28, and 30–34 weeks of gestation. HbA1c and 1‐h blood glucose were examined at ≤14 and 24–28 weeks. Neonatal birth weight was recorded.ResultsOf 312 women, HbA1c was more correlated with anthropometric measurements during pregnancy than 1‐h blood glucose. At 24–28 weeks, women with high/very high body fat percentage were more likely to have higher HbA1c. Women with high subscapular skinfold thickness were more likely to have higher 1‐h blood glucose at ≤14 and 24–28 weeks. High hip circumference significantly increased neonatal birth weights.ConclusionAnthropometric measurements were longitudinally correlated with HbA1c and 1‐h blood glucose, higher in the late second than first trimesters, as well as neonatal birth weight. The mechanisms to explain the relationship of different anthropometric measurements are required to be further studied.
Quantitative susceptibility mapping versus phase imaging to identify multiple sclerosis iron rim lesions with demyelination
Authors: Huang Weiyuan , Sweeney Elizabeth M. , Kaunzner Ulrike W. , Wang Yi , Gauthier Susan A. , Nguyen Thanh D. 
Published: March 2022

AbstractBackground and PurposeTo compare quantitative susceptibility mapping (QSM) and high‐pass‐filtered (HPF) phase imaging for (1) identifying chronic active rim lesions with more myelin damage and (2) distinguishing patients with increased clinical disability in multiple sclerosis.MethodsEighty patients were scanned with QSM for paramagnetic rim detection and Fast Acquisition with Spiral Trajectory and T2prep for myelin water fraction (MWF). Chronic lesions were classified based on the presence/absence of rim on HPF and QSM images. A lesion‐level linear mixed‐effects model with MWF as the outcome was used to compare myelin damage among the lesion groups. A multiple patient‐level linear regression model was fit to establish the association between Expanded Disease Status Scale (EDSS) and the log of the number of rim lesions.ResultsOf 2062 lesions, 188 (9.1%) were HPF rim+/QSM rim+, 203 (9.8%) were HPF rim+/QSM rim–, and the remainder had no rim. In the linear mixed‐effects model, HPF rim+/QSM rim+ lesions had significantly lower MWF than both HPF rim+/QSM rim– (p < .001) and HPF rim–/QSM rim– (p < .001) lesions, while the MWF difference between HPF rim+/QSM rim– and HPF rim–/QSM rim– lesions was not statistically significant (p = .130). Holding all other factors constant, the log number of QSM rim+ lesion was associated with EDSS increase (p = .044). The association between the log number of HPF rim+ lesions and EDSS was not statistically significant (p = .206).ConclusionsQSM identifies paramagnetic rim lesions that on average have more myelin damage and stronger association with clinical disability than those detected by phase imaging.