bluuebunny/crossref_metadata_2025_split huggingface dataset:
On‐line identification model for single phase‐earth fault in distribution network driven by wavelet transform and multi‐learner combination
Authors: Su Xueneng , Zhang Hua , Gao Yiwen , Zhang Jian , Song Tunfang 
Published: November 2022

AbstractThe detection of single phase‐earth faults has been a difficult task for a long time due to its very low current in high impedance grounded fault especially in a neutral un‐effectively grounded system. To address this issue, this paper firstly proposes multi‐learner based single phase‐earth fault identification models. First, to erase disturb noise in fault recording profiles, a denoising model is put forward based on the wavelet transform optimized via the proposed threshold improvement approach. Second, feature engineering reflecting local and/or global evolutionary process of fault evolving features is modelled, and in turn two key feature transforming techniques of principal component analysis (PCA) and random forest (RF) are individually employed to recognize the best effective combination of fault feature set. Subsequently, six learners of logistical regression (LR), support vector machine (SVM), K‐neighbor (KN), RF, XGBoost and LightGBM based fault identification models are individually custom‐designed which the feature subset in high priority are fed into. Furthermore, to guide the model optimization, several advanced manners of hyper‐parametric sampling via normal and Chi‐2 distribution, learning curve, validation curve, receiver operation characteristic curve (ROC) are applied. Numerical studies indicates the the high value of the proposed model when applied in engineering practice.
Composite Gaussian pulsed waveform for robust resonance radar signal
Authors: Aldhubaib Faisal 
Published: November 2022

AbstractThe paper assesses the feasibility of forming a composite excitation pulse with a high potential to combat the noise and onset ambiguity when estimating the target resonance behaviour in a radar target signal. The assessment investigates four composite pulse configurations of unified or adaptive setups for the fractional bandwidth and peak weight to find the best setup to enhance the resonance signature robustness. The assessment uses the method pencil function to extract the resonance parameters of the composite time data (coherent) and then to determine the degree of robustness over‐extraction onset and range of noise level. Determining the robustness rate requires finding the error between the original excitation frequencies and the extractable resonant frequencies and, second, the similarity between the original and reconstructed pulse waveforms. The qualitative assessments of the robustness merit concluded that the adaptive configuration of peak weight and small adaptive fractional bandwidth outperforms the other arrangements in enhancing the resonance return in radar signature.
Maternal Serum Gasdermin D Concentrations in Pregnancies Complicated
by Isolated Intrauterine Growth Restriction
Authors: Kobal Berna Buse , Kale İbrahim , Pektaş Ahmet Murat , Ozel Aysegul , Muhcu Murat 
Published: November 2022

Abstract
Objective We aimed to investigate the relationship between the isolated
intrauterine growth restriction (IUGR) and maternal serum gasdermin D (GSDMD)
concentration.
Materials and methods This cross-sectional study was conducted with 80
pregnant women who applied to the Umraniye Training and Research Hospital
Gynecology and Obstetrics Clinic between January 2022 and May 2022. The IUGR
group consisted of 40 pregnant women diagnosed with IUGR in the third trimester,
and the control group consisted of 40 healthy pregnant women matched with the
IUGR group in terms of age and BMI. Demographic characteristics, ultrasound
findings, and neonatal outcomes were noted. The two groups were compared in
terms of maternal serum GSDMD concentrations.
Results Both groups were similar in terms of demographic characteristics.
Fetal biometric measurements were found to be significantly lower in the IUGR
group compared to the control group, and umbilical artery Doppler PI and SD were
found to be higher. Gestational age, newborn birth weight, birth height, and
Apgar scores were significantly lower and NICU admission rate was higher in the
IUGR group. Gestational age at blood sampling for GSDMD was similar in both
groups (p=0.805). While maternal serum GSDMD concentration was
11.14 ng/ml in the IUGR group, it was 6.66 ng/ml
in the control group (p=0.000). ROC analysis was performed to determine
the value of GSDMD concentration in terms of IUGR estimation. AUC analysis of
GSDMD for IUGR estimation was 0.88 (p<.001, 95%
CI=0.80–0.95). The optimal cutoff value for GSDMD concentration
was determined as 8.84 ng/ml with 80% sensitivity and
75% specificity.
Conclusion Maternal serum GSDMD concentrations were found to be higher in
pregnant women whose pregnancy was complicated by isolated IUGR. We think that
high GSDMD concentrations may be a reflection of increased GSDMD-mediated
pyroptosis in placental tissue in isolated IUGR cases.
Palladium-Catalyzed C(sp2)–H Silylation via a Native-Amine-Directed Strategy
Authors: Yan Yintao , Wang Xuan , Li Jianhua , Jiang Chao 
Published: November 2022

AbstractA palladium-catalyzed C(sp2)–H silylation of morpholinones to afford silyl morpholinones is reported. The native secondary amine, which is tolerated in the reaction, is able to promote the C–H activation and silylation of the aryl group. The substrates are monosilylated selectively and tolerate various functional groups. The resulting silyl morpholinone derivatives are potentially useful in pharmaceuticals and agrochemicals.
Role of GPR56 in Platelet Activation and Arterial Thrombosis
Authors: Liu Dongsheng , Zhang Peng , Zhang Kandi , Bi Changlong , Li Li , Xu Yanyan , Zhang Tiantian , Zhang Junfeng 
Published: November 2022

AbstractThe adhesion G protein-coupled receptor GPR56 mediates cell–cell and cell–extracellular matrix interactions. To examine the function of GPR56 in platelet activation and arterial thrombosis, we generated GPR56-knockout mice and evaluated GPR56 expression in human and mouse platelets. The results revealed that the levels of the GPR56 N-terminal fragment were significantly higher on the first day after myocardial infarction than on the seventh day in the plasma of patients with ST-segment-elevation myocardial infarction. Next, we investigated the effects of GPR56 on platelet function in vitro and in vivo. We observed that collagen-induced aggregation and adenosine triphosphate release were reduced in Gpr56
−/− platelets. Furthermore, P-selectin expression on the Gpr56
−/− platelet surface was also reduced, and the spreading area on immobilized collagen was decreased in Gpr56
−/− platelets. Furthermore, collagen-induced platelet activation in human platelets was inhibited by an anti-GPR56 antibody. Gpr56
−/− mice showed an extended time to the first occlusion in models with cremaster arteriole laser injury and FeCl3-induced carotid artery injury. GPR56 activated the G protein 13 signaling pathway following collagen stimulation, which promoted platelet adhesion and thrombus formation at the site of vascular injury. Thus, our study confirmed that GPR56 regulated the formation of arterial thrombosis. Inhibition of the initial response of GPR56 to collagen could significantly inhibit platelet activation and thrombus formation. Our results provide new insights for research into antiplatelet drugs.
Impact of ABO Blood Group on Thromboembolic and Bleeding Complications in Patients with Left Ventricular Assist Devices
Authors: Tscharre Maximilian , Wittmann Franziska , Kitzmantl Daniela , Schlöglhofer Thomas , Cichra Philip , Lee Silvia , Eichelberger Beate , Wadowski Patricia P. , Laufer Günther , Wiedemann Dominik , Panzer Simon , Zimpfer Daniel , Gremmel Thomas 
Published: November 2022

Background The ABO blood group system is linked to hemostasis via its relationship with von Willebrand factor (VWF) and factor VIII (FVIII). In the current study, we investigated the association of the ABO system with clinical outcomes as well as VWF and platelet function in patients with left ventricular assist devices (LVADs).
Methods Bleeding and thromboembolic complications were assessed in 111 patients during 1 year after LVAD implantation. In 67 LVAD patients, VWF antigen, VWF activity, VWF ristocetin cofactor, VWF collagen-binding, and FVIII activity were assessed. Platelet surface P-selectin and activated glycoprotein IIb/IIIa were determined by flow cytometry, and soluble P-selectin was measured with an enzyme-linked immunoassay. Platelet aggregation was assessed by light transmission and impedance aggregometry.
Results Thirty-six patients (32.4%) experienced a bleeding and 22 patients (19.8%) a thromboembolic event. In univariate analyses, patients with blood group O had numerically more bleeding complications and less thromboembolic events as compared to patients with blood group non-O (both p ≥ 0.05). After multivariable adjustment, blood group O was significantly associated with a higher risk of bleeding (hazard ratio 2.42 [95% confidence interval 1.03–5.70], p = 0.044) but not linked to thromboembolic complications.
Conclusion Patients with blood group O had significantly lower levels of VWF and FVIII (all p < 0.05), whereas P-selectin expression in response to thrombin-receptor activating peptide and soluble P-selectin were higher as compared to patients with blood group non-O (both p < 0.05). LVAD patients with blood group O are at an increased bleeding risk, potentially due to lower VWF and FVIII levels.
Association of Chronic Periodontitis with Helicobacter pylori Infection in Stomach or Mouth: A Systematic Review and Meta-Analysis
Authors: Tsimpiris Athanasios , Tsolianos Ioannis , Grigoriadis Andreas , Moschos Ioannis , Goulis Dimitrios G. , Kouklakis Georgios 
Published: November 2022

AbstractHelicobacter pylori (H. pylori) infection and periodontitis are both inflammatory conditions associated with systemic diseases. Researchers have attempted to investigate the correlation between them. This systematic review and meta-analyses were conducted to investigate the association of H. pylori infection in the stomach and/or in subgingival plaque and gingival crevicular fluid with chronic periodontitis. The protocol was created according to the Preferred Reporting Items for Systematic review and Meta-Analysis Protocols (PRISMA-P) statement. The study was designed according to the Cochrane criteria. A comprehensive literature search was performed in MEDLINE, Scopus, and CENTRAL, combined with hand-searching and assessment of gray literature. The meta-analysis of the included studies was made by the Review Manager (RevMan) 5.4 software. The effect measure of the outcome was odds ratios with 95% confidence intervals. Heterogeneity was assessed by chi-square and I2. Four observational studies involving 818 subjects were included in this meta-analysis. The odds of oral H. pylori presence were higher in patients with chronic periodontitis, compared to healthy controls, with an odds ratio of 1.87 (95% confidence interval 0.85–4.10; p = 0.12). The odds of the presence of H. pylori in the stomach also were higher in patients with chronic periodontitis, with an odds ratio of 1.80 (95% confidence interval 0.82–3.95; p = 0.15). There is no evidence for an association between chronic periodontitis and the prevalence of H. pylori, detected either in subgingival plaque and gingival crevicular fluid or in the stomach.
Free-androgen Index in Women with Polycystic Ovarian Syndrome: A Meta-Analysis
Authors: Patil Prakash , D'Souza Neevan , Ghate Sudeep D. , Nagendra Lakshmi , Girijashankar Harish B. 
Published: November 2022

Abstract
Objectives Hyperandrogenism, a key feature of polycystic ovarian syndrome (PCOS), is caused by excess androgen secretion, most commonly of ovarian origin. Although the serum total testosterone (TT) levels have long been used as a traditional measure of hyperandrogenemia in women with PCOS, it is associated with many fallacies due to the fact that a component of TT is linked to sex hormone-binding globulin (SHBG). Recent research has discovered that measuring free testosterone levels and computing the free androgen index (FAI), which is a ratio of TT and SHBG, are better predictors of androgen excess in PCOS. The aim of this meta-analysis is to determine the association of FAI in diagnosing hyperandrogenism and its ability to discriminate PCOS from controls.
Materials and Methods The publicly available databases PubMed, Scopus and Web of Science were searched using MeSH terms, ‘Polycystic Ovarian Syndrome’ OR ‘PCOS’ OR ‘PCOD’ AND ‘Testosterone’ AND ‘Sex Hormone Binding Globulin’ OR ‘SHBG’ to collect the full-text articles for the retrieval of related data of case–control and cross-sectional studies. The studies quality was assessed using the Newcastle–Ottawa scale, and a sub-group analysis and publication bias between the studies was evaluated by funnel plot.
Statistical Analysis The R program (v4.0.3) and R packages ‘metafor’ and ‘dmetar’ were used for statistical analyses of quantitative data and the plots were generated using ‘ggplot2’ package through a comparison of pooled SMD by Egger's linear regression and Beggs-Mazumdar tests.
Results Twenty-four studies involving 7,847 participants including 3,290 controls and 4,557 PCOS were included in the meta-analysis. The pooled data analysis of the included studies showed that the PCOS women had higher FAI than controls, with SMD of 1.56 (95%CI 1.08–2.04; p < 0.01). The publication bias was tested using a funnel plot and Egger's regression asymmetry test, which revealed no risk of publishing bias (p = 0.1727). Additionally, the sub-group meta-analysis of geographic region revealed that FAI levels were more significant in PCOS subjects of Asia and Europe, compared with the American region.
Conclusion Overall, this meta-analysis indicates that FAI could be a reliable marker to differentiate PCOS patients from controls in Asian and European ethnicities.
A Bibliometric Analysis of Ophthalmology Resident Research Productivity in the United States
Authors: Huang Austin , Kim Sarah , Zhu Harrison , Pathare Nihar , Ooi Xin Yee , Kirby R. Parker , Yoon Stephen P. , Al-Mohtaseb Zaina 
Published: November 2022

Abstract
Background The extent and impact of ophthalmology resident scholarly output is not well known. The authors aim to quantify scholarly activity of ophthalmology residents during residency and assess what factors may be associated with greater research productivity of these residents.
Material and Methods Ophthalmology residents who graduated in 2021 were identified from their respective program Web sites. Bibliometric data published by these residents between the beginning of their postgraduate year 2 (July 1, 2018) until 3 months after graduation (September 30, 2021) were captured through searches via PubMed, Scopus, and Google Scholar. The association of the following factors with greater research productivity numbers was analyzed: residency tier, medical school rank, sex, doctorate degree, type of medical degree, and international medical graduate status.
Results We found 418 ophthalmology residents from 98 residency programs. These residents published a mean (±standard deviation [SD]) number of 2.68 ± 3.81 peer-reviewed publications, 2.39 ± 3.40 ophthalmology-related publications, and 1.18 ± 1.96 first-author publications each. The mean (±SD) Hirsch index (h-index) for this cohort was 0.79 ± 1.17. Upon multivariate analysis, we discovered significant correlations between both residency tier and medical school rank and all bibliometric variables assessed. Pairwise comparisons revealed that residents from higher tier programs had greater research productivity numbers than those from lower tier programs.
Conclusion We obtained bibliometric standards for ophthalmology residents on a national scale. Residents who graduated from higher-ranked residency programs and medical schools possessed higher h-indices and published more peer-reviewed publications, ophthalmology-related articles, and first-author publications.
Epistemologies of ignorance in far right studies: the invisibilisation of racism and whiteness in times of populist hype
Authors: Mondon Aurelien 
Published: November 2022

AbstractResearch on the far right has been a booming field for decades now, with far-right parties generally being much more researched than their right, centre and left counterparts, even when they are marginal in terms of politics or electoral support. Yet, for a field that is notorious for its lively definitional debates and tendency to evolve and reinvent itself terminologically, it has appeared unwilling to engage with the concepts of race, racism and whiteness, or with its very positioning in political structures. Through a mixed-methods discursive approach, this article analyses the titles and abstracts of all articles published in peer-reviewed journal in the sub-field of far right studies between 2016 and 2021 (n= 2543) to highlight which terms and concepts are primed and which are obscured. This article highlights a tendency to prime euphemising terms and concepts such as ‘populism’ and avoid those which engage with systemic and structural forms of oppression such as racism and whiteness. This article thus aims to both map and make sense of the absence of whiteness and racism in the corpus by arguing that it is a symbol of the ongoing presence of colourblind approaches and a lack of reckoning with the scale and pervasion of systemic racism in contemporary societies.
Ceramic hydroxyapatite chromatography plays a critical role in bispecific antibody purification process for impurity removal
Authors: Waller Jessica A , Zheng Ji , Dyer Rachel , Slaney Thomas , Wu Wei , Tao Li , Ghose Sanchayita 
Published: November 2022

Abstract

Background
Significant challenges exist in downstream purification of bispecific antibodies (BsAbs) due to the complexity of BsAb architecture. A unique panel of mispaired species can result in a higher level of product-related impurities. In addition to process-related impurities such as host cell proteins (HCPs) and residual DNA (resDNA), these product-related impurities must be separated from the targeted BsAb product to achieve high purity. Therefore, development of an efficient and robust chromatography purification process is essential to ensure the safety, quality, purity and efficacy of BsAb products that consequently meet regulatory requirements for clinical trials and commercialization.

Methods
We have developed a robust downstream BsAb process consisting of a mixed-mode ceramic hydroxyapatite (CHT) chromatography step, which offers unique separation capabilities tailored to BsAbs, and assessed impurity clearance.

Results
We demonstrate that the CHT chromatography column provides additional clearance of low molecular weight (LMW) and high molecular weight (HMW) species that cannot be separated by other chromatography columns such as ion exchange for a particular BsAb, resulting in ≥98% CE-SDS (non-reduced) purity. Moreover, through Polysorbate-80 (PS-80) spiking and LC–MS HCP assessments, we reveal complete clearance of potential PS-80-degrading HCP populations in the CHT eluate product pool.

Conclusions
In summary, these results demonstrate that CHT mixed-mode chromatography plays an important role in separation of product- and process-related impurities in the BsAb downstream process.
Temporality of ovarian steroids and LH/FSH pulse profiles encompassing selection of the dominant follicle in heifers
Authors: Gomez-Leon Victor E , Ginther O J , Domingues Rafael R , Sanglard Leticia P , Wiltbank Milo C 
Published: November 2022

AbstractThe tested hypotheses were (1) LH/FSH pulses and F2 diameter are diminished by P4 and, (2) E2 increases during the transition to deviation and alters LH/FSH pulses. On Day 5 (Day 0 = ovulation), heifers were randomized into an untreated group (HiP4, n = 11), and a prostaglandin analog treated group (NoP4, n = 10). On Day 6, a follicular wave was induced by follicle ablation. Ultrasound and blood collections were performed every 12 h from Days 7 to 11. Blood was collected every 15 min for 10 h on Day 9 (largest follicle expected to be ~7.5 mm). Estradiol was ~75% greater (0.36 ± 0.14 vs 0.63 ± 0.19 pg/mL) in heifers with F1 ≥ 7.2 mm than in heifers with F1 &lt; 7.2 mm. The HiP4 had smaller second largest follicle (F2) diameter, lower estradiol (P = 0.06), LH pulse baseline and peak concentrations (P &lt; 0.007), in addition to half the frequency of LH/FSH pulses (4.1 ± 0.3 vs 9.6 ± 0.7 in 10 h) than the NoP4. Within HiP4, heifers with F1 ≥ 7.2 mm had ~25% fewer (P = 0.03) LH pulses compared to heifers with F1 &lt; 7.2 mm. In contrast, within the NoP4, heifers with F1 ≥ 7.2 mm had ~75% greater LH (P = 0.05) and FSH (P = 0.08) pulse amplitude. We propose that greater F2 diameter at deviation in low P4 is related to greater LH baseline and peak concentrations, and greater frequency of LH/FSH pulses. A greater increase in E2 after F1 reaches ~7.2 mm results in further stimulation of LH/FSH pulse amplitude. Elevated P4 not only diminished frequency of LH/FSH pulses but also converted an E2 increase into a negative feedback effect on LH/FSH pulse frequency leading to smaller F2 at deviation.
Dynamic cellular and molecular characteristics of spermatogenesis in the viviparous marine teleostSebastes schlegelii
Authors: Wang Xueying , Liu Qinghua , Li Jun , Zhou Li , Wang Tao , Zhao Ning 
Published: November 2022

AbstractSpermatogenesis is a dynamic cell developmental process that is essential for reproductive success. Vertebrates utilize a variety of reproductive strategies, including sperm diversity, and internal and external fertilization. Research on the cellular and molecular dynamic changes involved in viviparous teleost spermatogenesis, however, is currently lacking. Here, we combined cytohistology, 10 × genomic single-cell RNA-seq, and transcriptome technology to determine the dynamic development characteristics of the spermatogenesis of Sebastes schlegelii. The expressions of lhcgr (Luteinizing hormone/Choriogonadotropin receptor), fshr (follicle-stimulating hormone receptor), ar (androgen receptor), pgr (progesterone receptor), and cox (cyclo-oxygen-ase), as well as the prostaglandin E and F levels peaked during the maturation period, indicating that they were important for sperm maturation and mating. Fifteen clusters were identified based on the 10 × genomic single-cell results. The cell markers of the sub-cluster were identified by their upregulation; piwil, dazl, and dmrt1 were upregulated and identified as spermatogonium markers, and sycp1/3 and spo11 were identified as spermatocyte markers. For S. schlegelii, the sperm head nucleus was elongated (spherical to streamlined in shape), which is a typical characteristic for sperm involved in internal fertilization. We also identified a series of crucial genes associated with spermiogenesis, such as spata6, spag16, kif20a, trip10, and klf10, while kif2c, kifap3, fez2, and spaca6 were found to be involved in nucleus elongation. The results of this study will enrich our cellular and molecular knowledge of spermatogenesis and spermiogenesis in fish that undergo internal fertilization.