bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cell-free DNA in sports medicine: implications for clinical laboratory medicine
Authors: Neuberger Elmo W.I. , Simon Perikles 
Published: May 2022

Abstract

Background
Physical activity can have a strong impact on the concentration of several promising candidate biomarkers, including cell-free DNA (cfDNA).

Content
This narrative review describes the current understanding of how physical strain leads to increases of cfDNA and discusses how this interferes with attempts to standardize cfDNA analysis in clinical laboratory medicine.

Summary
In general, all cells of the human body can release DNA, whereas neutrophils are described as the major source releasing cfDNA under resting conditions. Event at low physical load, cfDNA is rapidly released by immune cells. We recently, identified neutrophils as the major cell-type contributing to cfDNA increases during acute exercise. Both, endurance and strength training can affect the signal-to-noise ratio of liquid biopsy (LB) analysis, affecting the clinical validity between minutes up to several days. Furthermore, we discuss why physical distress of various kinds in a perioperative cancer setting can improve or compromise signal-to-noise. Therefore, physiological events including, but not limited to, activation of blood cells can provoke pre-analytical challenges for ultra-sensitive detection of cfDNA in LB settings.

Outlook
We discuss why future attempts to standardize liquid biopsy may therefore profit from a deeper understanding of the physiological release mechanisms of cfDNA.
Dialectical Abnormality? Jewish Alienation and Jewish Emancipation between Hegel and Marx
Authors: Yigit Emir 
Published: May 2022

Abstract
Karl Marx’s “On the Jewish Question” (1844) has fueled discussions around his early intellectual development as a Young-Hegelian thinker as well as debates about an allegedly distinct form of anti-Semitism native to Left-Hegelian and later to left-thinkers in general, Jewish and non-Jewish alike. In this essay, I argue that Marx’s assessment of contemporary Judaism is motivated by an underappreciated criticism of Hegelian historiography. Surveying the genealogy of the Hegelian treatments of Judaism between Hegel and Marx, I distinguish Marx’s intervention as a reaction to non-materialistic teleological historiography. This historiography assumes dialectical movement and demands practical change from those considered foreign to the movement. In contrast, this article suggests that Marx’s primary target is the belief that Judaism has been sublated into Christianity, that the abnormality lies not in Judaism’s historical persistence, but in the Christian pretense that the material contradictions Judaism was a response to have been overcome. Against the teleological nature of all renditions of Hegelian historiography, including Marx’s later historical-materialism, his “On the Jewish Question” weaponizes a hitherto unrecognized anti-teleological argument against the assimilationist views it responds to, of the kind that should evoke Nietzschean genealogy.
Crystal structure of 3-(3-bromophenyl)-1′,3′-dimethyl-2′H,3H,4H-spiro[furo[3, 2-c]chromene-2,5′-pyrimidine]-2′,4,4′,6′(1′H,3′H) tetraone, C22H15BrN2O6
Authors: Jiang Dong-Li , Fan Lian-Lian , Yin Peng , Liang Di , Li Rui 
Published: May 2022

Abstract
C22H15BrN2O6, monoclinic, P21/c (No. 14), a = 5.1760 (5) Å, b = 17.5652(19) Å, c = 21.734(2) Å, β = 94.690(3) °, Z = 4, V = 1969.3(3) Å3, R

gt
(F) = 0.0569, wR

ref
(F
2) = 0.1206, T = 170 K.
Hydrothermal synthesis and crystal structure of catena-poly[diaqua-bis(μ2-4-[(4-pyridinylmethyl)amino]benzoato-κ2
N:O)cobalt(II)]–1,2bi(4-pyridyl)ethene–water (1/1/1), C50H50N8O8Co
Authors: Guang-Zhen Liu , Li Ya-Di 
Published: May 2022

Abstract
C50H50N8O8Co, triclinic, P

1
‾

$\overline{1}$

, a = 9.2920(4) Å, b = 11.3648(5) Å, c = 11.9954(4) Å, α = 96.478(3)°, β = 104.766(3)°, γ = 103.901(4)°, V = 1168.40(8) Å3, Z = 1, R

gt
(F) = 0.0393, wR

ref
(F
2) = 0.1431, T = 293(2) K.
The crystal structure of poly[aqua-(μ2-4,4′- bis(imidazolyl)biphenyl-κ2
N:N′)-(μ2-3-nitrobenzene-1,2-dicarboxylato-κ2
O:O′)]copper (II) hydrate, C26H21N5O8Cu
Authors: Li Gui-Lian , Liu Meng-Ni , Du Gao-Jing , Zhang Jin-Yuan 
Published: May 2022

Abstract
C26H21N5O8Cu, monoclinic, P21/c (no. 14), a = 17.2262(10) Å, b = 7.3474(3) Å, c = 21.1086(11) Å, β = 111.498(6)°, V = 2485.8(2) Å3, Z = 4, Rgt
(F) = 0.0629, wRref
(F
2) = 0.1433, T = 293(2) K.
Housing and health in vulnerable social groups: an overview and bibliometric analysis
Authors: Chen Junhua , Hao Shuya , Wu Ying 
Published: May 2022

Abstract
Previous studies have confirmed that poor living conditions can lead to a wide range of health problems. However, in the context of the COVID-19 pandemic, vulnerable groups in unstable housing are more susceptible to disease. This study aims to systematically examine the housing and health problems of vulnerable groups using a bibliometric approach to explore how housing causes health problems, types of health illnesses, and coping strategies. It is found that the poor housing mechanism, persistent inequalities, and poor housing environments have a significant impact on the health of vulnerable groups. Therefore, the government must make concerted efforts across all sectors to ensure that the housing and health care needs of vulnerable groups are improved, and that housing security standards and related policies are improved; targeted safety plans are formulated with community as the carrier, taking into account the characteristics of vulnerable groups; and new information technology is widely used to provide medical convenience for vulnerable groups. It is hoped that the research in this paper can arouse social attention to the health of vulnerable groups and improve their health from the perspective of housing, so as to point out the direction for solving the housing health problems of vulnerable groups in the future.
Necessary and sufficient conditions in optimal control of mean-field stochastic differential equations with infinite horizon
Authors: Roubi Abdallah , Mezerdi Mohamed Amine 
Published: May 2022

Abstract
We consider an infinite horizon optimal control of a system where the dynamics
evolve according to a mean-field stochastic differential equation and the
cost functional is also of mean-field type. These are systems where the
coefficients depend not only on the state variable, but also on its marginal
distribution via some linear functional. Under some concavity assumptions on
the coefficients as well as on the Hamiltonian, we are able to prove a
verification theorem, which gives a sufficient condition for optimality for a
given admissible control. In the absence of concavity, we prove a necessary
condition for optimality in the form of a weak Pontryagin maximum principle,
given in terms of stationarity of the Hamiltonian.
Preparation and characterization of a graphene hybridizing polyurethane damping composite
Authors: Ma Chi , Zhang WeiLin , Wang LianHui , Guo Zhuo , Jiang Yan , Shan Yi , Chen JingYi , Wang Ying , Sin Lee Tin 
Published: May 2022

Abstract
A graphene hybridizing polyurethane/polyethyl methacrylate (GR-PU/PEMA) damping composite was synthesized using the sequential interpenetration method. The effects of the graphene content and the microphase separation structure on the damping properties, thermal stability, and mechanical properties have been studied in detail. The dynamic mechanical analysis indicated that graphene could improve the damping peak value of PU/PEMA, and the microphase separation structure could be beneficial for broadening the damping temperature range. The damping peak (tan σ
max) of PU/PEMA hybridizing with 0.5 wt% graphene reached 0.82, and the temperature range of the loss factor (tan σ ≥ 0.3) was expanded to 88.3°C. Analysis of scanning electron microscopy, transmission electron microscopy, and small-angle X-ray scattering reveals that graphene is uniformly dispersed in the polymer matrix, and the composite with interpenetrating polymer network (IPN) shows more microphase separation structures. Fourier transform infrared analysis indicated that there is strong interaction between graphene and IPN matrix. Furthermore, the addition of graphene improved the mechanical properties and thermal stability of composites.
Neuropathy and pain after breast cancer treatment: a prospective observational study
Authors: Bennedsgaard Kristine , Grosen Kasper , Attal Nadine , Bouhassira Didier , Crombez Geert , Jensen Troels S. , Bennett David L. , Ventzel Lise , Andersen Inge S. , Finnerup Nanna B. 
Published: May 2022

Abstract

Objectives
Neurological complications including pain are common after treatment for breast cancer. This prospective study investigated the symptoms, intensity and interference of chemotherapy-induced peripheral neuro-pathy. (CIPN) in the feet and hands compared to surgery- and radiation-induced neuropathy in the breast and upper arm.

Methods
Consecutive patients referred to surgery for breast cancer were included in a prospective study and completed a questionnaire at baseline and a follow-up questionnaire and interview after one year. CIPN was assessed with the CIPN20 questionnaire and the Michigan Neuropathy Screening Instrument questionnaire (MNSIq). Pain intensity was rated on a numeric rating scale (NRS, 0–10).

Results
In total 144 patients were included, of which 73 received chemotherapy. At one-year follow-up, symptoms of polyneuropathy were more common in patients treated with chemotherapy. Tingling or numbness in the feet in those treated/not treated with chemotherapy was reported by 44 (62%) and 15 (21%), respectively. Pain was present in 22 (30%) and 10 (14%), respectively. Pain in the area of surgery was reported by 66 (46%). Although less common, pain in the feet in those treated with chemotherapy was rated as more intense and with more daily life interference than pain in the surgical area (NRS 5.5 (SD 1.9) vs. 3.1 (SD 1.9).

Conclusions
Neurological complications including pain following surgery and chemotherapy represent a burden to breast cancer survivors. In those who had received chemotherapy, pain in the feet was less common than pain in the surgical area, but pain in the feet was more intense and had a higher interference with daily life. Our study emphasizes the need for either baseline data or a control population for improved estimation of the presence and severity of CIPN and pain from questionnaires.
Individual cortisol response to acute stress influences neural processing of sexual cues
Authors: Stark Rudolf , Markert Charlotte , Kruse Onno , Walter Bertram , Strahler Jana , Klein Sanja 
Published: May 2022

Abstract

Background and aims
Problematic pornography use can be conceptualized as an impulse control disorder or alternatively as a behavioral addiction. Stress is an important trigger in addiction, but less is known about the neural effect of stress in problematic pornography use. Therefore, we aimed at investigating the effect of stress during the anticipation and viewing of sexually explicit material while considering person characteristics related to potentially being at risk for developing problematic pornography use.

Methods
In an fMRI study (n = 157 men, age: mean = 25.46, SD = 4.11) we used a sexual incentive delay task. A social stress test was used to induce stress in half of the participants. Salivary cortisol was repeatedly measured and person characteristics were considered moderating the effects of cortisol response.

Results
We found no group differences in the neural responses during the anticipation phase, but a higher reactivity to sexual stimuli in the dACC in the stress group. Acute stress activated a pronounced cortisol response, which positively correlated with neural activations in the reward system (NAcc, dACC) to sexual cues. Further, the individual time spent on pornography use moderated the effect of cortisol in some regions of the reward system (dACC, mOFC).

Discussion and conclusions
Our results suggest that acute stress related increases in cortisol can enhance the incentive value of cues announcing sexual stimuli. This might explain why acute stress is considered a trigger of pornography use and relapse and why individual stress response might be a risk factor for developing a problematic pornography use.
Identifying etiological pattern for postpartum complications
Authors: Kurbanova D. F. , Sultanova S. G. , Hajiyevа F. R. 
Published: May 2022

Introduction. Postpartum complications hold one of the leading places in the pattern of gynecological diseases.Aim: to study the clinical and laboratory features of developing postpartum inflammatory complications.Materials and Methods. There were examined 150 puerperas at the Scientific Research Institute of Obstetrics and Gynecology (Baku, Azerbaijan) in the years from 2019 to 2021, who were subdivided into 2 groups: the main group – puerperas with developed postpartum complications (n = 100), aged 29.9 ± 0.64 years and the control group – puerperas with a physiological course of postpartum period (n = 50), aged 30.3 ± 0.86 years (p = 0.679). We studied the general and obstetric-gynecological anamnesis. The following parameters of the peripheral blood samples were analyzed: total leukocyte count, absolute and relative lymphocyte level, erythrocyte and platelet counts, the hemoglobin concentration, erythrocyte sedimentation rate, and quantity of serum interleukin-6 (IL-6).Results. It was found that puerperas of the main vs. control group had increased level of serum pro-inflammatory cytokine IL-6 (24.26 ± 0.48 pg/ml vs. 10.36 ± 0.62 pg/ml; p = 0.001) considered as an additional risk factor for developing postpartum complications. Regarding cellular immune parameters, they were shown to have decreased CD4+/CD8+ ratio due to blood elevated CD8+ lymphocyte count and decreased level of CD4+ T-cells. The development of postpartum inflammatory complications in the main group was associated with menstrual disorders in 81.0 ± 3.92 % of cases, first births – in 60.0 ± 4.90 %, threatened miscarriage – in 19.0 ± 3.92 % and gestational toxicosis – in 52.0 ± 5.00 % of the total cases. Some risk factors were associated with diseases of the genitourinary system (main vs. control groups: chronic pyelonephritis 24.0 ± 4.27 % and 10.0 ± 4.24 %, respectively; p = 0.048) and respiratory organs, most often represented by chronic tonsillitis and sinusitis (main vs. control groups: 20.0 ± 4.00 % vs. 4.0 ± 2.77 %, respectively; p = 0.007).Conclusion. The course of the postpartum period in primiparas as well as women with burdened history of obstetric-gynecological and extragenital pathology is characterized by a high proportion of inflammatory complications. Biochemical studies assessing peripheral blood T-lymphocyte count and serum level of the pro-inflammatory cytokine IL-6 can be used as an additional diagnostic method to identify and assess modality and severity of early puerperal complications.
Awareness about minimally invasive dentistry among dental under graduates & Interns: A cross-sectional study
Authors: Kashyap Nilotpol , Rani Shreya , Patel Soni , Dey Aparna , Singh Nishi 
Published: May 2022

Minimally Invasive Dentistry (MID) is a modern concept that attempt to keep teeth functional for life. It is the management of caries with biological approach rather than traditional surgical approach. It is to leave the traditional GV Black concept of ‘Extension for Prevention’ behind. Now, the present-day principle is ‘Constriction with Conservation’. This has been noticed that the concept of MID is still very unclear to the practicing dentists & even to the undergraduates. To understand the knowledge and awareness of undergraduates about MID a survey is important. The aim of this study is –Firstly, to assess the knowledge about MID technique among the undergraduate students and interns from my dental institution. Secondly, to also investigate whether the knowledge acquired by the students reflects in the form of a positive attitude towards practice of MID principles. A cross-sectional survey involving 50 dental students and interns of my dental institution. The questioner is close ended. The questions are to assess the respondent levels of agreement regarding diagnostic, preventive and minimally invasive restorative techniques. In this study it was found that interns had greater knowledge of MID than final years as they had greater clinical exposure. There is a need to introduce evidence-based dentistry in the dental curriculum as well as establish guidelines for caries detection, diagnosis, treatment discussion & treatment performance.
Orthosurgical management of deckbiss malocclusion (Class-II Div 2) in adult patients: A case series
Authors: Kamboj Ashish , Chopra SS , Thapa Amrit , Kochar Gagandeep , Mohanty Pritam , Sinha Nishant 
Published: May 2022

Class II malocclusion cases are of interest to orthodontists since they constitute a significant chunk of cases they treat. Still, they're one of the most grueling malocclusions to diagnose and treat.There lies a significant difference in the frequency of Class II malocclusion among various populations. The frequency of Class II malocclusion in India varies from 1.9% in Rajasthan to 8.37% in South India. Class II division 2 (Deckbiss) malocclusion is characterized by mandibular incisors positioned posterior to the cingulum of retroclined maxillary incisors. It usually presents with reduced overjet and increased overbite.The treatment approach of Class II division 2 malocclusion is different for different age groups. In growing cases, growth modulation with myofunctional appliances is recommended but in adult cases, orthodontic camouflage or orthognathic surgery is the recommended treatment modality. When orthodontic treatment alone is ineffective or when facial aesthetics is grossly undermined, orthognathic surgery is the choice of treatmentIn the present case series, two adult cases of severe Class II division 2 (Deckbiss) malocclusion were treated orthosurgically with BSSO. This case series demonstrates that treatment of Class II division 2 (Deckbiss) malocclusion in adult patients is a challenging task and a combined orthodontic-surgical approach can be used to obtain optimum aesthetics & functional efficiency.
Desenvolvimento motor de prematuros nascidos abaixo de 2.500g no primeiro ano de vida: interferência do crescimento infantil
Authors: Sangali Caroline Sangali Cenci , De Toni Tainá , Trubian Fernanda , Lodi Mayra Nathu , Bonetti Leandro Viçosa , Saccani Raquel 
Published: May 2022

Objetivo: verificar se há relação entre o desenvolvimento motor e o crescimento infantil de crianças nascidas prematuras abaixo de 2.500 g até os 12 meses de idade corrigida. Métodos: Pesquisa descritiva e observacional, de caráter associativo e delineamento transversal, com 85 prematuros até 12 meses e peso ao nascer abaixo de 2.500g. Retirou-se do prontuário informações das características biológicas e ambientais da criança. Para o desenvolvimento motor, foi utilizada a Alberta Infant Motor Scale (AIMS) e para avaliar o crescimento, as informações foram colocadas em gráficos de referência da Organização Mundial da Saúde. Na análise de dados, utilizou-se teste de Correlação de Pearson e teste de Qui Quadrado de Pearson (nível de significância foi p<0,05). Resultados: O peso (p=0,001) e IMC (p< 0,0001) demonstraram correlação moderada e significativa com o percentil de desempenho motor dos bebês. Ademais, as associações dos indicadores de crescimento com as categorias de desempenho motor também foram significativas, tanto em peso (p=0,01) quanto em IMC (p=0,04). A estatura demonstrou correlação mais baixa, porém significativa (0,05) com a categorização de desempenho motor. Conclusão: Observa-se forte relação entre o crescimento infantil e o desenvolvimento motor de crianças prematuras. Foi demonstrado que os indicadores antropométricos de peso e IMC tiveram importantes interações com o desenvolvimento motor das crianças.
The Burden of Senescent Dysfunctional Telomeres in Normal Cells – a Pilot Study
Authors: Kahl Vivian Francilia Silva 
Published: May 2022

Introdução: Telômeros disfuncionais são críticos para a saúde humana. Eles podem ser identificados pelo seu comprimento, pela prevalência de variantes nas repetições teloméricas e pela frequência de danos localizados nos telômeros, marcados pela presença de -H2AX.Materiais e Métodos: Usando o ensaio de disfunção telomérica induzida (mTIF), esse estudo investigou a presença de TCAGGG, uma repetição telomérica variante, e sua associação com a repetição canônica (TTAGGG) em uma linhagem cancerígena (HT1080) e uma linhagem celular normal (MRC-5) humanas ao longo de um período (120 dias).Resultados: Devido à parada do crescimento celular que acompanha a senescência, as células MRC-5 em estágio final de duplicação de população (DP) apresentaram telômeros particularmente curtos quando comparadas às células HT1080 em qualquer estágio e à MRC-5 em estágio inicial de DP. Células cancerígenas exibiram elevados níveis da variante TCAGGG, tanto sozinha ou colocalizada com a sequência canônica. As linhagens HT1080 e MRC-5 em estágio inicial tiveram níveis de -H2AX aumentados quando co-localizados à sequência canônica, à sequência variante, e às duas sequências combinadas, quando comparadas com MRC-5 em estágio final.Conclusão: Este estudo piloto identificou que a linhagem de fibrossarcoma HT1080 é mais suscetível à ocorrência de variantes teloméricas, enquanto células normais em estágio final exibem mais altos níveis de telômeros disfuncionais, indicados por telômeros mais curtos e presença aumentada de -H2AX.
Study on effect of fly ash and limestone powder on compressive strength of roller compacted concrete for dam construction
Authors: Ojha P N , Singh Brijesh , Singh Pranay , Singh Abhishek , Mandre Manish Kumar 
Published: May 2022

Roller compacted concrete (RCC) is a special concrete having similar ingredients as in the case of conventional concrete, but in different proportions. Use of fly ash to replace significant proportion of Portland cement (PC) for RCC mix is very popular. However, use of limestone in RCC is not so popular. Limestone can act as an inert filler as well as can take part in hydration process and development of different hydration products to a limited extent. The study attempts to determine the optimal replacement levels of PC using fly ash and limestone for development of high volume fly ash based roller compact concrete with limestone filler for use in construction of dams in India by evaluating the fresh properties (in terms of Vee Bee time, density and setting time) and compressive strength (at 7, 28, 56, 90 and 180 days) for different RCC mixes having varying proportions of PC, fly ash and limestone. The study evaluation of 17 RCC mixes prepared by replacing PC to an extent of 72% (by weight of total cementitious content) using two types of fly ash and two types of limestone from different sources to observe the variations in setting time, short and long-term strength for the concrete. For RCC mixes having ternary cementitious systems (combination of OPC, fly ash and limestone), setting time values were observed to be in between setting times of mixes made with binary cementitious systems (i.e. OPC and limestone & OPC and fly ash). Optimum performance in terms of compressive strength at all the ages was observed for mixes with ternary cementitious system due to the synergistic contributions (physical and chemical) of both fly ash and limestone.