bluuebunny/crossref_metadata_2025_split huggingface dataset:
Approximating the Manifold Structure of Attributed Incentive Salience from Large-scale Behavioural Data
Authors: Bonometti Valerio , Ruiz Mathieu J. , Drachen Anders , Wade Alex 
Published: July 2022

AbstractIncentive salience attribution can be understood as a psychobiological mechanism ascribing relevance to potentially rewarding objects and actions. Despite being an important component of the motivational process guiding our everyday behaviour its study in naturalistic contexts is not straightforward. Here we propose a methodology based on artificial neural networks (ANNs) for approximating latent states produced by this process in situations where large volumes of behavioural data are available but no experimental control is possible. Leveraging knowledge derived from theoretical and computational accounts of incentive salience attribution we designed an ANN for estimating duration and intensity of future interactions between individuals and a series of video games in a large-scale (N > 3 × 106) longitudinal dataset. We found video games to be the ideal context for developing such methodology due to their reliance on reward mechanics and their ability to provide ecologically robust behavioural measures at scale. When compared to competing approaches our methodology produces representations that are better suited for predicting the intensity future behaviour and approximating some functional properties of attributed incentive salience. We discuss our findings with reference to the adopted theoretical and computational frameworks and suggest how our methodology could be an initial step for estimating attributed incentive salience in large-scale behavioural studies.
Hybrid biocomposites based on polylactic acid and natural fillers from Chamaerops humilis dwarf palm and Posidonia oceanica leaves
Authors: Scaffaro Roberto , Maio Andrea , Gammino Michele 
Published: July 2022

AbstractPlatelet-like and fibrous lignocellulosic fillers were achieved from the leaves of Chamaerops humilis (CHL) and Posidonia oceanica (POL) and used as a hybrid reinforcement for a polylactic acid (PLA) matrix at three different loading levels (from 5 to 20%). The materials were fully characterized from a morphological, physicochemical, mechanical, and dynamic-thermomechanical point of view. When compared to their counterpart containing either CHL or POL only, the resulting hybrid biocomposites showed the highest mechanical properties, with strengthening and stiffening effects respectively up to 120% and 50% higher than those expected from the linear combination of the two, and higher dynamic-mechanical performance, with storage moduli in the rubbery region 10 times higher than those of composites containing solely CHL or POL. Such synergistic efficiency is likely due to the formation of a strong and extensive interphase region, promoted by the balanced effect of morphological features of the hybrid network and physicochemical characteristics of the components. These green materials could find applications as panels for furniture or in the automotive industry.
Graphical Abstract
‘The Silence Kills Me.’: ‘Silence’ as a Trigger of Speaking-Related Anxiety in the English-Medium Classroom
Authors: Maher Kate , King Jim 
Published: July 2022

Abstract
Classroom interpersonal dynamics play a key role in shaping the interactional profiles of language learners and the development of their speaking skills. However, it can be challenging for learners to navigate social interactions with classmates, especially if they lack confidence in their L2 self. This is especially true for first-year undergraduates in Japan who often struggle to adapt to unfamiliar communicative language lessons taught in the target language. King’s (2013) examination of learner silence established a connection between low oral participation, anxiety, and social inhibition. In some cases, however, silence is not just a non-verbal cue of speaking-related anxiety (Maher & King, 2020); it can also be a contributing factor to avoiding talk. Using King’s (2014) cognitive-behavioural model of silent L2 learners’ anxiety, this paper examines how ‘silence’ can trigger speaking-related anxiety in Japanese university English-medium classrooms. The study used a cognitive-behavioural theory (CBT)-based approach to gain insights into students’ perceptions of their in-class behaviours. Forty-five semi-structured interviews were conducted with 17 participants using an interview schedule based on a CBT formulation to explore students’ silent behaviour, associated thoughts and feelings, and behavioural triggers. Multiple recurrent forms of classroom ‘silence’ reported by the participants included using Japanese when English was expected, finishing speaking turns quickly, and taking on the listener role rather than initiating discourse. The findings reveal ‘silence’ as a trigger of speaking-related anxiety. The discomfort some participants felt during a display of ‘silence’ seemed to trigger a fear of being negatively evaluated by classmates, leading to self-doubt about their language proficiency and social performance. These findings contribute further insights into the causes of speaking-related anxiety and learner ‘silence’. Our study points towards using CBT-based approaches to improve speaking confidence by increasing learners’ awareness of their anxiety triggers.
Enteropathogenic Escherichia coli (EPEC) expressing a non-functional bundle-forming pili (BFP) also leads to increased growth failure and intestinal inflammation in C57BL/6 mice
Authors: Ledwaba Solanka Ellen , Bolick David Thomas , de Medeiros Pedro Henrique Quintela Soares , Kolling Glynis Luanne , Traore Afsatou Ndama , Potgieter Natasha , Nataro James Paul , Guerrant Richard Littleton 
Published: July 2022

Abstract
Bundle-forming pili (BFP) are implicated in the virulence of typical enteropathogenic E. coli (EPEC), resulting in enhanced colonization and mild to severe disease outcomes; hence, non-functional BFP may have a major influence on disease outcomes in vivo. Weaned antibiotic pre-treated C57BL/6 mice were orally infected with EPEC strain UMD901 (E2348/69 bfpA C129S); mice were monitored daily for body weight; stool specimens were collected daily; and intestinal tissues were collected at the termination of the experiment on day 3 post-infection. Real-time PCR was used to quantify fecal shedding and tissue burden. Intestinal inflammatory biomarkers lipocalin-2 (LCN-2) and myeloperoxidase (MPO) were also assessed. Infection caused substantial body weight loss, bloody diarrhea, and intestinal colonization with fecal and intestinal tissue inflammatory biomarkers that were comparable to those previously published with the wild-type typical EPEC strain. Here we further report on the evaluation of an EPEC infection model, showing how disruption of bfp function does not impair, and may even worsen diarrhea, colonization, and intestinal disruption and inflammation. More research is needed to understand the role of bfp in pathogenicity of EPEC infections in vivo.
Stability and interaction of biochar and iron mineral nanoparticles: effect of pH, ionic strength, and dissolved organic matter
Authors: Liu Yong , Ma Jie , Gao Jiaoli , Chen Xingyi , Ouyang Xiaoxue , Weng Liping , Li Haiming , Chen Yali , Li Yongtao 
Published: July 2022

AbstractBiochar nanoparticles (BCNPs) and iron mineral nanoparticles (IMNPs), such as ferrihydrite nanoparticles (FHNPs), magnetite nanoparticles (MTNPs), and goethite nanoparticles (GTNPs), are often combined and used in soil remediation. However, the stability and interaction of nanoparticles under various environmental conditions have not been investigated previously. In this study, settling experiments, a semi-empirical model, the Derjaguin–Landau–Verwey–Overbeek (DLVO) theory, scanning electron microscopy (SEM) observations, and quantum chemical calculations were used to study the interaction and heteroaggregation of BCNPs and IMNPs. Settling of BCNPs-FHNPs and BCNPs-GTNPs was stable at neutral and alkaline pH (relative concentration of unsettled nanoparticles Cres’ = 0.679–0.824), whereas fast settling of BCNPs-IMNPs was observed at acidic pH (Cres’ = 0.104–0.628). By contrast, BCNPs-MTNPs consistently showed moderate settling regardless of the mass of magnetite at all pH (Cres’ = 0.423–0.673). Both humic acid (HA, 10 mg L−1) and ionic strength (IS, 10 and 100 mM) facilitated the settling of BCNPs-FHNPs and BCNPs-MTNPs systems, whereas the settling of BCNPs-GTNPs was sensitive only to IS. Fulvic acid (10 mg L−1) had a general stabilizing effect on the BCNPs-IMNPs systems. The results of SEM and quantum chemical calculations suggested that the interaction between BCNPs and FHNPs (-2755.58 kJ mol−1) was stronger than that between BCNPs and GTNPs (−1706.23 kJ mol−1) or MTNPs (−1676.73 kJ mol−1). The enhancement of heteroaggregation between BCNPs and IMNPs under unfavorable conditions (acidic pH, HA, and IS) was regulated by the strength of the interaction. Therefore, the enhancement of heteroaggregation of BCNPs-FHNPs was greater than that of BCNPs-MTNPs. In the BCNPs-GTNPs system, the high concentration and elongated structure of GTNPs may contribute greatly to heteroaggregation and settling with small interactions. Our results highlight the influence of pH, IS, and HA on the interaction between BCNPs and IMNPs. These results will be helpful in the application of BCNPs and IMNPs for soil remediation.
Graphical Abstract
Additive pharmacological interaction between sirtuin inhibitor cambinol and paclitaxel in MCF7 luminal and MDA-MB-231 triple-negative breast cancer cells
Authors: Wawruszak Anna , Okon Estera , Telejko Ilona , Czerwonka Arkadiusz , Luszczki Jarogniew 
Published: July 2022

Abstract
Background
Breast cancer (BC) is the most common malignancy and the leading cause of cancer-related death in women worldwide. Sirtuin inhibitors (SIRTi), belonging to the histone deacetylase inhibitors group (HDIs), are potent epigenetic drugs that have been investigated for therapeutic use in different clinical disorders, including hematological malignancies and solid tumors.

Methods
The influence of cambinol (CAM; SIRTi) used individually or in combination with standard chemotherapeutic paclitaxel (PAX) on viability (MTT assay), proliferation (BrdU assay), induction of apoptosis and cell cycle arrest (FACS analysis) was determined in MCF7 luminal and MDA-MB-231 triple-negative breast cancer (TNBC) cells. The types of pharmacological drug–drug interaction between CAM and PAX were determined by an exact and rigorous pharmacodynamic method—an isobolography, to determine the presence of synergism, addition or antagonism between analyzed drugs using a variety of fixed-dose ratios.

Results
The combination of CAM and PAX at a fixed ratio of 1:1 exerted additive interaction in the viability of MCF7 and MDA-MB-231 BC cells. Both active agents used separately reduced viability and proliferation of BC cells as well as induced apoptosis and cell cycle arrest. These effects were much more evident in MCF7 than in MDA-MB-231 BC cells. Additionally, CAM combined with PAX increased anti-cancer activity compared to PAX used alone.

Conclusion
CAM might be considered a potential therapeutic agent individually or in combined therapy with PAX against luminal or TNBC.

Graphical abstract
An altitude capable rig for studying engine inlet velocity profile effects: Boundary layer generator
Authors: Rasimarzabadi F. , Clark C. , Neuteboom M. , Orchard D. , Martensson H. 
Published: July 2022

AbstractA new aerodynamic open-circuit test rig for studying boundary layer ingestion (BLI) propulsion has been developed by National Research Council of Canada. The purpose is to demonstrate the advantages of BLI in reducing the power required for a given thrust and to validate the performance of BLI fan concepts. The rig consists of a boundary layer generator to simulate boundary layer development over an aircraft fuselage. The boundary layer generator can be used to create a natural boundary layer due to skin friction but also comprises an array of perforated plates through which pressurised air can be blown to manipulate the boundary layer thickness. The size of the boundary layer thickness can be controlled upstream of the fan blades. Parametric studies of boundary layer thickness were then feasible. The test calibration was conducted to validate the concept.
Enhanced backstepping control for an unconventional quadrotor under external disturbances
Authors: Belmouhoub A. , Medjmadj S. , Bouzid Y. , Derrouaoui S. H. , Guiatni M. 
Published: July 2022

AbstractRobust control of non-linear systems is a challenging task, notably in the presence of external disturbances and uncertain parameters. The main focus of this paper is to solve the trajectory tracking problem of an unconventional quadrotor with rotating arms (also known as a foldable drone), while overcoming some of the challenges associated with this type of vehicle. Therefore, in a first step, the model of this vehicle is presented, taking into account the change of the inertia, the centre of gravity, and the control matrix. The theoretical foundations of backstepping control, based on the finite time Lyapunov stability theory and enhanced by a Super-Twisting algorithm, are then discussed. Numerical simulations are performed to demonstrate the efficiency of the suggested control approach. Finally, a qualitative and quantitative comparative study of the proposed controller with the conventional backstepping controller is performed. Overall, the obtained results show that the proposed control strategy outperforms in terms of accuracy and resilience.
Against Irrationalism in the Theory of Propaganda
Authors: HYSKA MEGAN 
Published: July 2022

AbstractAccording to many accounts, propaganda is a variety of politically significant signal with a distinctive connection to irrationality. This irrationality may be theoretical, or practical; it may be supposed that propaganda characteristically elicits this irrationality anew, or else that it exploits its prior existence. The view that encompasses such accounts we will call irrationalism. This essay presents two classes of propaganda that do not bear the sort of connection to irrationality posited by the irrationalist: hard propaganda and propaganda by the deed. Faced with these counterexamples, some irrationalists will offer their account of propaganda as a refinement of the folk concept rather than as an attempt to capture all of its applications. The author argues that any refinement of the concept of propaganda must allow the concept to remain essentially political, and that the irrationalist refinement fails to meet this condition.
Trends in hospital antibiotic utilization during the coronavirus disease 2019 (COVID-19) pandemic: A multicenter interrupted time-series analysis
Authors: Elligsen Marion , Wan Michael , Lam Philip W. , Lo Jennifer , Taggart Linda R. , Chan April J. , Downing Mark , Gough Kevin , Seah Jenny , Leung Elizabeth 
Published: July 2022

Abstract

Objective:
To describe the evolution of respiratory antibiotic prescribing during the coronavirus disease 2019 (COVID-19) pandemic across 3 large hospitals that maintained antimicrobial stewardship services throughout the pandemic.

Design:
Retrospective interrupted time-series analysis.

Setting:
A multicenter study was conducted including medical and intensive care units (ICUs) from 3 hospitals within a Canadian epicenter for COVID-19.

Methods:
Interrupted time-series analysis was used to analyze rates of respiratory antibiotic utilization measured in days of therapy per 1,000 patient days (DOT/1,000 PD) in medical units and ICUs. Each of the first 3 waves of the pandemic were compared to the baseline.

Results:
Within the medical units, use of respiratory antibiotics increased during the first wave of the pandemic (rate ratio [RR], 1.76; 95% CI, 1.38–2.25) but returned to the baseline in waves 2 and 3 despite more COVID-19 admissions. In ICU, the use of respiratory antibiotics increased in wave 1 (RR, 1.30; 95% CI, 1.16–1.46) and wave 2 of the pandemic (RR, 1.21; 95% CI, 1.11–1.33) and returned to the baseline in the third wave, which had the most COVID-19 admissions.

Conclusions:
After an initial surge in respiratory antibiotic prescribing, we observed the normalization of prescribing trends at 3 large hospitals throughout the COVID-19 pandemic. This trend may have been due to the timely generation of new research and guidelines developed with frontline clinicians, allowing for the active application of new research to clinical practice.
Comparing the Psychological Problems Among the Health Care Workers Across Two Waves of SARS-CoV-2 (COVID-19) Pandemic: An Observational Study from India
Authors: Gupta Snehil , Basera Devendra , Purwar Shashank , Poddar Lily , Rozatkar Abhijit R. , Kumar Mohit , Jahan Rahat , Gautam Disha 
Published: July 2022

Abstract

Objective:
Literature investigating the change in psychological problems of the health care workers (HCWs) throughout the coronavirus disease (COVID-19) pandemic is lacking. We aimed at comparing the psychological problems and attitudes toward work among HCWs over two waves of the COVID-19 pandemic in India.

Methods:
A survey was conducted involving HCWs (n = 305, first wave, 2020; n = 325, second wave, 2021). Participants’ demographic and professional and psychological characteristics (using attitude toward COVID-19 questionnaire [ATCQ]; Depression, Anxiety, and Stress Scale – 21 Items and impact of event scale – 22) were recorded. The unpaired t-test/chi-squared test was used for comparison.

Results:
Significant improvements (χ2(1) = 7.3 to 45.6, P < 0.05) in level of depression (42.2% vs 9.6%), anxiety (41.3% vs 16.3%), stress (30.1% vs 6.7%), event-related stress symptoms (31.2% vs 27%), work-related stress (89.8% vs 76.8%), and stigma (25.9% vs 22.8, though marginally significant) were found among the participants of the second wave (vs first wave). However, on subgroup analysis, allied-HCWs (housekeeping staff and security personnel) reported lesser concerns over the domains of the ATCQ vis-a-viz frontline-HCWs (doctors and nurses).

Conclusion:
This improvement could be attributed to greater awareness about the illness, better coping skills, vaccination, and so forth; however, more research is warranted to investigate these determinants.
COVID-19 (SARS-CoV-2) in Patients Treated in The Unified Health System (SUS) with Flu and Respiratory Symptoms from Three Brazilian Municipalities in the Border Region
Authors: Gonçalves Sereno Arianne Peruzo Pires , de Sousa Dahiane Locatelli , Gimenes Pollyanna Santos , Czezaniak Wanylla Paula dos Santos , Moretto Lorena de Fátima , Rey Laisa Marina Rosa , Fazoli Kawany Gabrieli Zanetti , Cassaro Luís Antônio , Santos Isabela Carvalho dos , Barbosa Lidiane Nunes , Gonçalves Daniela Dib 
Published: July 2022

Abstract

Objective:
The objective of this study was to investigate the prevalence and carry out epidemiology using sociodemographic data from patients with symptoms suggestive of coronavirus disease (COVID-19) (SARS-CoV-2) in 3 bordering Brazilian municipalities.

Methods:
An epidemiological survey of positive cases of COVID-19 through reverse transcriptase polymerase chain reaction (RT-PCR) was carried out in 1874 patients, seen in the Unified Health System (SUS), ages between 0 and 99 years, who had symptoms suggestive of COVID-19, from the cities of Assis Chateaubriand, Tupãssi, and Formosa do Oeste.

Results:
It was possible to observe that of the 1874 patients seen in the public health network of the 3 municipalities, 354 were diagnosed as positive. The predominance of cases was in female patients (51.97%) and in patients who lived in urban areas (93.50%), and the predominant age group was 20–29 years (19.78%).

Conclusion:
The result of this study demonstrated the epidemiological profile of patients with respiratory and flu-like symptoms, positive for COVID-19, in 3 municipalities bordering Paraguay and Argentina. It was evident that the age group has its specificities regarding the susceptibility of the infection. Although the borders are closed, there was probably a spread of the virus in this region, due to the diversion, which showed an increase during the pandemic period.
Obesity-related genomic instability and altered xenobiotic metabolism: possible consequences for cancer risk and chemotherapy
Authors: Bankoglu Ezgi Eyluel , Stopper Helga 
Published: July 2022

Abstract
The increase in the prevalence of obesity has led to an elevated risk for several associated diseases including cancer. Several studies have investigated the DNA damage in human blood samples and showed a clear trend towards increased DNA damage in obesity. Reduced genomic stability is thus one of the consequences of obesity, which may contribute to the related cancer risk. Whether this is influenced by compromised DNA repair has not been elucidated sufficiently yet. On the other hand, obesity has also been linked to reduced therapy survival and increased adverse effects during chemotherapy, although the available data are controversial. Despite some indications that obesity might alter hepatic metabolism, current literature in humans is insufficient, and results from animal studies are inconclusive. Here we have summarised published data on hepatic drug metabolism to understand the impact of obesity on cancer therapy better. Furthermore, we highlight knowledge gaps in the interrelationship between obesity and drug metabolism from a toxicological perspective.
THE MIYAKE EVENT IN 993 CE RECORDED IN OAK SUB-ANNUAL TREE RINGS FROM KUJAWY (POLAND)
Authors: Rakowski Andrzej , Krąpiec Marek , Huels Matthias , Pawlyta Jacek , Wiktorowski Damian 
Published: July 2022

ABSTRACTThis article presents measurements of the radiocarbon (14C) concentration in sub-annual tree rings. Samples of earlywood (EW) and latewood (LW) from dendrochronologically dated tree rings (English oak, Quercus robur) from Kujawy, near Kraków (Poland), spanning the years of 990–997 CE, are extracted and their 14C content is measured at the Center for Applied Isotope Studies at the University of Georgia, USA. The EW and LW data show a gradual increase in the Δ14C values between 991–995 CE, which are similar to those observed by Rakowski et al. (2018). An increase of 10.3 ± 2.6‰ in Δ14C for the EW data, and 8.6 ± 2.6‰ for the LW data has been recorded for this period. Using this data, it is possible to estimate the time period for when a major historical event occurred, which seems to have been in the late summer (September –2/+1 month) of 993 CE.
Quantification of the effect of host patch configuration on the abundance of Bemisia tabaci in central Argentina: a multimodel inference approach
Authors: Grilli Mariano P. , Bruno Marina , Fachinetti Romina 
Published: July 2022

AbstractBemisia tabaci is a complex of species, which is considered the most common and important pest of a wide range of crops belonging to many different botanical families. In Argentina, this species is recognized as a vector of geminiviruses, and Middle East-Asia Minor 1, Mediterranean, New World and New World 2 have been found to coexist in the same area. Landscape elements, like habitat patch area and isolation, define the habitat configuration and have a direct effect on insect populations between and within host patches. In this paper, we analyse the effect of potato patch configuration on the distribution and abundance of B. tabaci. Potato patches were identified using Landsat TM5 and TM7 images, and a supervised classification was performed to quantify the spatial distribution of the patches in the whole study area. Potato patch metrics were estimated using Fragstats 4.4. Generalized linear mixed models were employed to analyse the relationship between whiteflies and landscape configuration, through a multimodel inference approach, finding that B. tabaci abundance and landscape metrics were very variable. After a multimodel selection process, we found that perimeter-to-area ratio and Euclidean distance between patches were the variables that best explained whitefly abundance in potato patches. Implications of these findings are discussed.