bluuebunny/crossref_metadata_2025_split huggingface dataset:
Stress Distribution in Restored Primary Molar Using Finite Element Analysis
Authors: Abuarqoub Obay , Whba Ahmed , Metwally Kamal G , Elkalla Ibrahim H 
Published: December 2022

Abstract
The purpose of this study was to evaluate the stress distribution in normal tooth structure and restoration at different preparation designs restored with stainless-steel crown (SSC), zirconia crown (Zr), and amalgam. Six carious primary mandibular second molar were used. The molars were divided into three main groups: Group I (restored with Amalgam), Group II (restored with SSC), and Group III (restored with Zr). Each group was subdivided into Subgroup A (Class II Cavity with MOD extension) and Subgroup B (pulpotomy with MO cavity extension). The restored teeth were imaged for CBCT to create a finite element model for each one. These models were transferred to ANSYS software and subjected to an average simulated masticatory force of 245 N. Regarding the tooth structure, under different force directions and cavity designs, the dentin structure of models restored with amalgam displayed von Mises stress more than models restored with SSC. The lowest von Mises stress value showed in models restored with Zr. Regarding the final restorative material under different force directions and cavity designs, the amalgam recorded the lowest value of von Mises stress than Zr and SSC. The SSC and Zr distribute occlusal stresses significantly more than amalgam restoration. Furthermore, Zr distributes occlusal stresses slightly more than SSC.
Dynamics analysis of magnetic spring-based nonlinear oscillator system
Authors: Ahamed Raju , Howard Ian , McKee Kristoffer Koh 
Published: December 2022

Abstract
This paper aims to study the dynamics of the single-degree-of-freedom (SDOF) magnetic spring based oscillator system. The proposed oscillator system contains a nonmagnetic shaft, a floating permanent magnet (PM), and two fixed permanent magnets (PMs). All PMs are placed in such a way that they can repel each other. At first, the proposed system's magnetic properties and magnetic restoring force are studied. Experimental and numerical analysis have been carried out to validate the analytical investigation of the magnetic restoring force. The linear and nonlinear coefficients of the oscillator system are analysed from the magnetic restoring force. Moreover, how the gravitational force affects the equilibrium position is studied by varying the height of the oscillator. The magnetic restoring forces for different oscillator heights are also analysed. In addition, the system dynamics, such as damping ratio, eigenvalues and natural frequencies of the oscillator system, are investigated with and without electromechanical coupling. Finally, the proposed system's energy generation capacity is examined using electromechanical coupling.
A study on the suitability of 3D printed models to analyse sounds of the whistling arrows
Authors: COBAN Recep Efe , AKAN Mertcan 
Published: December 2022

Abstract
Whistling arrows are military equipment that can make a whistling sound through their whistles, which are usually made of horns or bone. Surprisingly, this highly intriguing weapon is one of the least studied subjects in the medieval archery legacy. The reason for this might be that the whistling arrows are very difficult to manufacture and test. On the other hand, using 3D printers has by researchers to test and analyse archaeological artifacts nowadays. Likewise, the affordable prices of 3D printers and the manufacturing speed of the models are also increasing these studies. In this context, our article aims to test the hypothesis of using 3D models produced by 3D printers to overcome the difficulties in producing whistling arrows. Three different whistle types dating to the Turk Khaganate period were selected to use in the tests, and ten 3D whistle models were printed out following these typologies. All whistles were tested in the prepared test setup and their sounds were recorded and analysed.
Vitamin D receptor and vitamin D binding protein gene polymorphisms in patients with asthma
Authors: Daina Bastyte , Laura Tamasauskiene , Ieva Golubickaite , Rasa Ugenskiene , Brigita Sitkauskiene 
Published: December 2022

Abstract
Background.
Vitamin D and its metabolites are transported to tissues and cells bound to a specific vitamin D binding protein (VDBP also known as GC-globulin). Most biological actions of this vitamin are exerted through the vitamin D receptor (VDR). Polymorphisms in VDR or VDBP genes may affect vitamin D level, influencing the pathogenesis of asthma. The aim of this study was to investigate the possible association of VDR and VDBP gene single-nucleotide polymorphisms (SNP), serum 25-hydroxyvitamin D, blood eosinophils and total IgE level in subject with asthma in comparison with healthy individuals.
Methods.
In total 63 subjects with asthma (45 allergic and 18 non-allergic) and 32 healthy subjects were involved in the study. Sensitization of subjects to inhaled allergens was determined by skin prick test, lung function was evaluated by spirometry. Serum 25-hydroxyvitamin D, total IgE levels were evaluated by ELISA. Eosinophils evaluation were performed on an automated hematology analyzer (Sysmex, Japan). DNA was isolated using the QIAamp DNA blood mini kit. Polymorphisms in the VDR and VDBP gene on the 12q13.11 chromosomal region were analyzed using TaqMan SNP Genotyping Assay probes.
Results.
We observed lower serum 25-hydroxyvitamin D level in patients with allergic asthma and non-allergic asthma compared to healthy subjects (13.96 ± 0.79 ng/ml and 15.35 ± 0.99 ng/ml vs 22.55 ± 1.23 ng/ml, p < 0.01). In asthma patients with vitamin D deficient (< 20 ng/ml) the allele G of Rs11168293 on VDR was more common than in those having insufficiency (20–30 ng/ml) of vitamin D (62.9% and 31.3%, p < 0.05). Moreover, asthmatic subject with Rs11168293 G allele has significant higher blood eosinophil count (% of leukocytes) compared to asthmatic without the Rs11168293 G allele (8.45 ± 12.27% vs 5.14 ± 1.52%, p < 0.05). Significantly higher IgE level was found in subjects with allergic asthma with the allele A of Rs7041 on VDBP gene than in those without this allele (536.4 ± 106.1 and 239.0 ± 75.8 IU/ml, p < 0.05).
Conclusions.
The association of polymorphisms in VDBP and VDR gene, the rs11168293 G allele and the rs7041 A allele, with serum 25-hydroxyvitamin D, blood eosinophil and total IgE level in asthma, let us suggest that vitamin D, VDR and VDBP gene polymorphisms are important in pathogenesis of asthma despite its form in relation to atopy.
Vicia articulata, a traditional crop legume, near extinction, found in Santorini (Thera), Greece; possible implication for archaeobotany/ palaeoethnobotany and its great value for its future need in agriculture.
Authors: Sarpaki Anaya , Skoula Melpo , Katsipis Sampson 
Published: December 2022

Abstract
Vicia articulate Horne. a not highly domesticated legume, which is used as green manure, fodder and, in times of stress, as food, is in the process of extinction. Although it was mentioned as cultivated up to the 1950s in many parts of Greece, lately, the only area, which is known to still cultivate it, is on the Cycladic island of Santorini, Thera, and referred to as ‘lentil’.
The aim of this paper is threefold: a) to intercept its extinction, as it is an excellent plant for green manuring and fodder and enriches, the soil with nutrients and humidity, under arid conditions. Its importance in agriculture and husbandry needs to be redressed. It produces even under ≤ 300 mm of rain, which is of utmost importance in times of Climate Change. B) to draw the attention of archaeobotanists to pay more attention in identifying lentil-type legumes in the archaeological contexts, and widen our knowledge on the legumes cultivated in the past, as well as build their biographies regarding their domestication trajectories and use. C) Call for the attention of ethnobotanists, archaeobotanists and farmers to cooperate, protect and promote traditional systems of agriculture, which are more sustainable, in arid environments.
Diversity of individuals' methylation patterns to different moisture regimes in Einkorn wheat revealed by CRED-RA technique
Authors: Hosseini Narges , Zarei Leila , Cheghamirza Kianoosh 
Published: December 2022

Abstract
Among the wild relatives of wheat, diploid species with desirable characteristics have high potential in crop modification. One of the important epigenetic changes that is associated with the pattern of gene expression and causes genetic instability is DNA methylation. The coupled restriction enzyme digestion-random amplification (CRED-RA) technique and five RAPD primers were used to study methylation changes in two Einkorn wheat genotypes including S10 and H9 genotypes and four soil water availability treatments included control, mild, moderate and severe stress (irrigation at 100%, 75%, 50% and 25% of field capacity, respectively) in two stages (14 days after water deficiency and 14 days after re-watering). The experiment was laid out as 2×4 factorial experiment within completely randomized design replicated three times. Measured physiological traits included relative leaf water content, Fv / Fm and stomatal conductance. After 14 days of exposure to drought stress, the results showed that the lowest relative water content of leaves, Fv/Fm and stomatal conductance were related to severe stress treatment. Also, S10 genotype was superior to H9 after application of moisture stress treatments and after re-watering. Different patterns of methylation were observed in different replications of each treatments in response to severe water deficiency, which can be due to the diversity of individuals' response to stress and the specificity of epigenetics changes. Most of the fragments that showed a change in methylation pattern due to water deficiency, after stress removal, returned to the state before stress, which indicates the reversibility of methylation changes in the genome.
An optimized workflow for MS-based quantitative proteomics of challenging clinical bronchoalveolar lavage fluid (BALF) samples
Authors: Weise Danielle O. , Kruk Monica E. , Higgins LeeAnn , Markowski Todd W. , Jagtap Pratik D. , Mehta Subina , Mickelson Alan , Parker Laurie L. , Wendt Christine H. , Griffin Timothy J. 
Published: December 2022

Abstract

BackgroundClinical Bronchoalveolar lavage fluid (BALF) samples are rich in biomolecules, including proteins, and useful for molecular studies of lung health and disease. However, mass spectrometry (MS)-based proteomic analysis of BALF is challenged by the dynamic range of protein abundance, and potential for interfering contaminants. A robust, MS-based proteomics compatible sample preparation workflow for BALF samples, including those of small and large volume, would be useful for many researchers.ResultsWe have developed a workflow that combines high abundance protein depletion, protein trapping, clean-up, andin-situtryptic digestion, that is compatible with either qualitative or quantitative MS-based proteomic analysis. The workflow includes a value-added collection of endogenous peptides for peptidomic analysis of BALF samples, if desired, as well as amenability to offline semi-preparative or microscale fractionation of complex peptide mixtures prior to LC-MS/MS analysis, for increased depth of analysis. We demonstrate the effectiveness of this workflow on BALF samples collected from COPD patients, including for smaller sample volumes of 1-5 mL that are commonly available from the clinic. We also demonstrate the repeatability of the workflow as an indicator of its utility for quantitative proteomic studies.ConclusionsOverall, our described workflow consistently provided high quality proteins and tryptic peptides for MS analysis. It should enable researchers to apply MS-based proteomics to a wide-variety of studies focused on BALF clinical specimens.
A Retrospective Analysis of the Functional and Radiological Outcomes of Surgically Treated Acetabular Fractures using the Modified Stoppa Approach
Authors: Cetin Huzeyfe , Abdallah Anas , Ucan Vahdet , Kara Deniz , Elmadag Nuh Mehmet 
Published: December 2022

Abstract
Purpose: To evaluate the functional and radiological outcomes of acetabular fractures treated with the modified Stoppa approach (mSA) at our department.
Methods: At our institution, the medical charts of patients diagnosed with an acetabular fracture were reviewed retrospectively. Patients who underwent surgery with the mSA between 2012 and 2020 were selected as core samples of this study.
Results: In total, 40 patients (24 males and 16 females) were operated on consecutively. The mean age was 37.4± 16.3 years. The mean preoperative duration was 4.5 ± 2.9 days. The mechanism of injury was motor vehicle accidents in 22 patients (55%). According to the Judet–Letournel classification, ten patients had fractures with anterior and posterior column types. According to Matta's criteria, the anatomical reduction achieved in 30 patients (75.0%) was poor in four and was imperfect in six. According to Matta's radiological staging, radiographic outcomes in 23 patients were excellent. The radiological stage was significantly better in elementary fractures than in complex fractures (p = 0.02). Merle d'Aubigné’s hip score was excellent in 17 patients. Harris hip score was excellent in 22 patients, good in 15, moderate in two and poor in one. Intraoperative iliac vein injury developed in two patients, postoperative superficial infection in one and inguinal hernia developed in two during a mean follow-up period of 32.6± 23.9 months.
Conclusions: Our findings indicate that the mSA is an appropriate treatment approach for many complicated acetabular fractures. This approach gave acceptable radiological and functional outcomes for the selected patients.
Maternal apparent temperature during pregnancy on the risk of offspring asthma and wheezing: effect, critical window, and modifiers
Authors: Zhang Jiatao , Bai Shuoxin , Lin Shaoqian , Cui Liangliang , Zhao Xiaodong , Du Shuang , Wang Zhiping 
Published: December 2022

Abstract
The objective of this study was to explore the impact of maternal AT during pregnancy on childhood asthma and wheezing, as well as the potential effect modifiers in this association. A cross-sectional study was implemented from December 2018 to March 2019 in Jinan to investigate the prevalence of childhood asthma and wheezing among aged 18 months to 3 years. Then, we conducted a case-control study based on population to explore the association between prenatal different AT exposure levels and childhood asthma and wheezing. The association was assessed by generalized additive model and logistic regression model, and stratified analyses were performed to explore potential effect modifiers. A total of 12,384 vaccinated children participated in screening for asthma and wheezing, and 236 cases were screened, as well as 1445 controls were randomized. After adjusting for the covariates, childhood asthma and wheezing was significantly associated with cold exposure in the first trimester, with OR 1.750 (95% CI: 1.145–2.673), and cold exposure and heat exposure in the third trimester, with ORs 1.583 (95% CI: 1.013–2.474) and 2.124 (95% CI: 1.415–3.188). In the third trimester, enhanced impacts were found among girls, children whose distance of residence was close to the nearest main traffic road, children whose mothers never had vitamin D supplementation, and children whose parents have asthma. The study indicates that exposure to extreme AT during the first trimester and the third trimester could increase the risk of childhood asthma and wheezing.
Prevalence, Symptoms and Professional Profile of the Burnout Syndrome among Healthcare Professionals during the COVID-19 Pandemic: a Cross-Sectional Study
Authors: Puigtió-Rebollo Núria , Serdà-Ferrer Bernat Carles , Gacto-Sánchez Mariano 
Published: December 2022

Abstract
The Burnout Syndrome (BOS) is a psycho-emotional disorder generating sustained stress over time, and inability to cope with the demands in an adaptive manner. The aims of the study were (1) to describe the prevalence of BOS during the third COVID-19 pandemic wave (May-June 2021); (2) to explore the relation of BOS with physical symptoms, and (3) to determine the profile favoring the development of BOS. This cross-sectional descriptive study was conducted amongst a sample of 759 healthcare professionals (HCPs). Data on sociodemographic variables, physical symptoms, the Maslach Burnout Inventory, Cervical Disability Index, and Numeric Pain Rating Scale were collected. The prevalence of BOS was 58.9% (447 subjects); 382 subjects (50.3%) showed high levels of Emotional Exhaustion (EE), whereas 219 participants (28.9%) had high Depersonalization (DP) levels, whilst 135 individuals (17.8%) showed low levels of Personal Fulfillment (PF). Women showed higher levels of EE (Z=-3.46; p = 0.001), whilst men showed higher levels of DP (Z=-2.69; p = 0.007). A total of 579 participants (76.3%) experienced muscle pain. A young nurse working in a hospital, or an emergency department emerges as a specific vulnerable profile. The current study confirms the need to overcome BOS in HCPs, implementing multidimensional tailored intervention to decrease the symptoms.
Respiratory system Talaromyces marneffei infection in HIV-negative children
Authors: Yang Qin , Wu Yue , Li Xiaonan , Bao Yanmin , Wang Wenjian , Zheng Yuejie 
Published: December 2022

Abstract
Background
Respiratory symptoms are the earliest clinical manifestation of Talaromyces marneffei (TM) infection. In this study, we aimed to improve the early identification of TM infection in human immunodeficiency virus (HIV)-negative children with respiratory symptoms as the first manifestation, analyze the risk factors, and provide evidence for diagnosis and treatment.
Methods
We retrospectively analyzed six cases of HIV-negative children with respiratory system infection symptoms as the first presentation.
Results
All subjects (100%) had cough and hepatosplenomegaly, and five subjects (83.3%) had a fever; other symptoms included lymph node enlargement, rash, rales, wheezing, hoarseness, hemoptysis, anemia, and thrush. Additionally, 66.7% of the cases had underlying diseases (three had malnutrition, one had severe combined immune deficiency [SCID]). The most common coinfecting pathogen was Pneumocystis carinii, which occurred in two cases (33.3%), followed by one case of Aspergillus (16.6%). Furthermore, the value of β-D-glucan detection (G experimental) increased in 50% of the cases, while the proportion of NK decreased in six cases (100%). Five children (83.3%) were confirmed to have the pathogenic genetic mutations. Three children (50%) were treated with amphotericin B, voriconazole, and itraconazole, respectively; three children (50%) were treated with voriconazole and itraconazole. All children were tested for itraconazole and voriconazole plasma concentrations throughout antifungal therapy. Two cases (33.3%) relapsed after drug withdrawal within 1 year, and the average duration of antifungal treatment for all children was 17.7 months.
Conclusion
The first manifestation of TM infection in children is respiratory symptoms, which are nonspecific and easily misdiagnosed. When the effectiveness of anti-infection treatment is poor for recurrent respiratory tract infections, we must consider the condition with an opportunistic pathogen and attempt to identify the pathogen using various samples and detection
Exponential concentration and untrainability in quantum kernel methods
Authors: Thanasilp Supanut , Wang Samson , Cerezo Marco , Holmes Zoë 
Published: December 2022

Abstract

Kernel methods in Quantum Machine Learning (QML) have recently gained significant attention as a potential candidate for achieving a quantum advantage in data analysis. Among other attractive properties, when training a kernel-based model one is guaranteed to find the optimal model's parameters due to the convexity of the training landscape. However, this is based on the assumption that the quantum kernel can be efficiently obtained from a quantum hardware. In this work we study the trainability of quantum kernels from the perspective of the resources needed to accurately estimate kernel values. We show that, under certain conditions, values of quantum kernels over different input data can be exponentially concentrated (in the number of qubits) towards some fixed value, leading to an exponential scaling of the number of measurements required for successful training. We identify four sources that can lead to concentration including: the expressibility of data embedding, global measurements, entanglement and noise. For each source, an associated concentration bound of quantum kernels is analytically derived. Lastly, we show that when dealing with classical data, training a parametrized data embedding with a kernel alignment method is also susceptible to exponential concentration. Our results are verified through numerical simulations for several QML tasks. Altogether, we provide guidelines indicating that certain features should be avoided to ensure the efficient evaluation and the trainability of quantum kernel methods.
Glucose Solution Through the Hepatic Artery May Focus Irreversible Electroporation Into the Tumor. A Preliminary Safety and Efficacy Evaluation
Authors: Sarreshtehdari Amirhossein , Burdio Fernando , López-Alonso Borja , Lucía Óscar , Burdio José Miguel , Villamonte María , Andaluz A. , García-Arnas F. , Berjano E. , Moll Xavier 
Published: December 2022

Abstract
Tissue electrical properties like impedance greatly impact irreversible electroporation (IRE) function. Infusion of glucose solution 5% (GS5%) through the Hepatic artery would focus IRE on scattered tumors of the liver. By creating a differential impedance between healthy and tumor tissue. This study aimed to determine the effects of the GS5% protocol on the liver and its safety. 21 male Athymic nude rats Hsd: RH-Foxn1mu were used in the study. Animals were split into two groups. In group 1, a continuous infusion through the gastroduodenal artery of GS5% was performed to measure the impedance with a dose of 0.008 mL/g for 16 minutes. In group 2, the animals were divided into two subgroups for infusions of GS5%. Group 2.1, at 0.008 mL/g for 16 minutes. Group 2.2 at 0.03 ml/g for 4 minutes. Blood samples were collected after anesthesia has been induced. The second sample, after catheterization of the artery, and the third after the GS5% infusion. All the animals were sacrificed to collect histological samples. The survival rate during the experiment was 100%. A considerable impact on the impedance of the tissue was noticed, on average up to 4.31 times more than the baseline, and no side effects were observed after GS5% infusion. In conclusion, to decrease IRE’s side effects on healthy tissue (without portal irrigation), GS5% could be a practical therapeutic solution.