bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Place Within a Place: Location Choice by Intentional Communities
Authors: Zacharya Heli , Meir Avinoam , Alfasi Nurit 
Published: June 2022

ABSTRACTThe classic geographical question of choosing a location has received little attention in studies on urban intentional communities (ICs), despite ICs being, as we suggest, geographical entities. As a group of people organised under shared norms and goals, who reside together in a particular geographical space and are involved in frequent, intensive relationships, an IC requires a location (city or neighbourhood) that is commensurate with its goals. We look upon it as a multi‐stage process of selecting a location that also involves the ex post‐facto evaluation of ICs' sense of place and place‐making needed for the chosen location to be successful. Three Israeli ICs are analysed through interviews with insights drawn regarding this process. We propose using these insights as a foundation towards a broader global discussion on locational choice by ICs.
Survey of ocular abnormalities in draft horses
Authors: Sheridan Colleen K. , Myrna Kathern E. , Nunnery Catherine M. , Czerwinski Sarah L. 
Published: June 2022

AbstractObjectiveTo determine the prevalence of ocular disease in draft horses in the United States.AnimalsDraft horses of various breeds and ages.ProcedureNondilated ophthalmic examination was performed using slit lamp biomicroscopy and indirect ophthalmoscopy. Intraocular pressures were measured when possible.ResultsOne hundred sixty‐five draft horses were examined. Age range: 10 days to 33 years (mean 10.8 years, median 10 years); 87 geldings (52.7%), 71 mares (43.0%), 7 stallions (4.2%); 64 Percherons (38.8%), 51 Belgians (30.9%), 29 Clydesdales (17.6%), 15 Shires (9%), and 6 other draft breed (3.6%). Intraocular pressure: mean 24.7 mmHg OD, range 13‐37 mmHg; mean 25.0 mmHg OS, range 11‐37 mmHg. Vision‐threatening disease was present in 9 horses (5.5%): complete cataracts 1, post‐traumatic optic nerve atrophy 1, uveitis and secondary glaucoma 1, retinal detachment 1, large chorioretinal scar 3, phthisis bulbi 2. Non‐vision‐threatening ocular disease was present in 56 horses (33.9%) involving one or more ocular structures: eyelid trauma/notch defect 14 (8.5%), SCC‐type adnexal lesions 12 (7.3%), corneal scars 16 (9.7%), keratitis 6 (3.6%), corpora nigra cyst 15 (9.1%), incipient/punctate cataract 50 (30.3%), vitreous degeneration 10 (6.1%), asteroid hyalosis 1, “bullethole” chorioretinal scars 3, RPE coloboma 1. Linear keratopathy was present in 28 horses (17%) with 2/28 having concurrent vision threatening ocular disease.ConclusionsOcular abnormalities, in particular minor cataracts, were relatively common in this population, but not typically vision‐threatening. Additionally, this survey demonstrated a greater prevalence of linear keratopathy in draft horses compared with reports in other breeds; however, it does not appear to be associated with concurrent ocular disease.
A Preform Design Approach for Uniform Strain Distribution in Forging Processes Based on Convolutional Neural Network
Authors: Lee Seungro , Kim Kyungmin , Kim Naksoo 
Published: June 2022

Abstract
This study provides a preform design approach for uniform strain distribution in forging products based on a convolutional neural network (CNN). The appropriate preform design prevents underfill problems by improving the material flow inside forging dies and achieving a uniform strain distribution in forging products. The forging deformation process and mechanical properties are improved with a uniform strain distribution. The forging and strain distribution results are analyzed through rigid–plastic finite element forging simulations with different initial geometries. The simulation data are fed into the CNN model as an input array, from which the geometric characteristics are extracted by convolution operations with filters (weight array). The extracted features are linked to the considered initial shapes, which are input into the CNN model as an output array. The presented model derives the preform shape for a target forging with uniform strain distributions using the training weights. According to the training database, the proposed design method can be applied to different forging geometries without any iterations. By creating a number of low-level CNN (LC) models based on the training data, the efficiency of the preform design can be improved. The best preform among the derived preform candidates is chosen by comparing the forging results. Compared with previous studies using the same design criteria, the proposed model predicted the preform with a strain distribution improved by 16.3–38.4%.
Numerical Study of Heat Transfer During Oblique Impact of a Cold Drop on a Heated Liquid Film
Authors: Singh Swati , Saha Arun K. 
Published: June 2022

Abstract
A three-dimensional study of a cold droplet impacting obliquely on a heated solid flat surface covered with a hot liquid layer has been performed. The drop Weber number, liquid film thickness, and drop impact angle are set to a range from 100 to 800, 0.1 to 0.4, and 0 deg to 60 deg, respectively. The interface evolution and thermal behavior of the drop impingement is well captured using coupled level set and volume of the fluid method (CLSVOF). The code is validated against previously published results both qualitatively and quantitatively. The results show that in the case of oblique drop impact, the crown dynamics and wall heat flux distribution exhibit an asymmetric pattern, with secondary droplets generated solely on the downstream side, as opposed to normal drop impact in which the secondary drops generated around the circumference of the crown. Based on heat flux values, two distinct region within the liquid film exist: (i) impact region around the impact point and (ii) undisturbed region far from the impact region characterized by the impact dynamics. A parametric analysis further reveals that for a moderate Weber number, asymmetric behavior increases as the drop impact angle increases, resulting in a reduction in heat transfer from the solid surface. However, for a drop impacting at an angle of 28 deg, increased asymmetry due to a increase in the Weber number results in significant cooling of the impact region. Furthermore, it is also found that a thinner liquid film promotes higher heat transfer from the solid surface, resulting in a higher wall heat flux.
Ongoing retinal degeneration despite intraventricular enzyme replacement therapy with cerliponase alfa in late-infantile neuronal ceroid lipofuscinosis type 2 (CLN2 disease)
Authors: Dulz Simon , Schwering C , Wildner Jan , Spartalis Christoph , Schuettauf Frank , Bartsch Udo , Wibbeler Eva , Nickel Miriam , Spitzer Martin Stephan , Atiskova Yevgeniya , Schulz Angela 
Published: June 2022

Background/aimsLate-infantile neuronal ceroid lipofuscinosis type 2 (CLN2) is a neurodegenerative, blinding lysosomal storage disorder. The purpose of the current study was to characterise the progression of CLN2-associated retinal degeneration in patients under intraventricular enzyme replacement therapy (ERT) with cerliponase alfa.MethodsWe analysed visual function, retinal morphology and neuropaediatric data using preferential looking test (PLT), Weill Cornell Batten Scale (WCBS), optical coherence tomography (OCT) imaging and the Hamburg Motor-Language late-infantile neuronal ceroid lipofuscinosis (LINCL) Scale (M-L scale).ResultsFifty-six eyes of 28 patients had baseline PLT, WCBS and OCT. 15 patients underwent serial examinations, resulting in a total of 132 OCT scans and WCBS results, 66 Hamburg M-L scores and 49 PLT results during a mean follow-up time of 18.2 months (range 5–40). A negative correlation (r=–0.69, p<0.001) was found between central retinal thickness (CRT) values and age at examination with a maximal annual decrease of 23 µm between 56 and 80 months of age. A significant correlation was observed between PLT results and the age at examination (r=0.46, p=0.001), the WCBS scores (r=0.62; p<0.001) and CRT values (r=–0.64; p<0.001). The M-L score correlated with the ocular measurements (CRT: r=0.58, p<0.001; WCBS r=−0.64, p<0.001; PLT score: r=−0.57, p<0.001).ConclusionDespite intraventricular ERT, retinal degeneration progressed in patients with CLN2 and was particularly pronounced between 56 and 80 months of age. Retina-directed therapies should therefore be initiated before or as early as possible during the phase of rapid retinal degeneration. PLT and WCBS were identified as valuable outcome measures to monitor disease progression.Trial registration numberNCT04613089.
Impact of urbanisation on the gaps of hypertension prevalence, awareness and treatment among older age in China: a cross-sectional study
Authors: Yu Qiutong , Zuo Genyong 
Published: June 2022

ObjectivesTo examine the impact of urbanisation on the prevalence, awareness and treatment of hypertension among elderly in China.DesignThis cross-sectional study used data from the most recent nationally representative Chinese Longitudinal Healthy Longevity Survey, 2018.SettingPeople in urban and rural communities from 500 sample areas in 22 Chinese provinces.ParticipantsAfter exclusion, this study surveyed 9859 participants in the final analysis.Primary and secondary outcome measuresThe main dependent variables were prevalence, awareness and treatment of hypertension defined as (1) systolic blood pressure (BP)≥140 mm Hg, diastolic BP≥90 mm Hg or (2) taking antihypertensive drugs. Hypertension awareness was defined as a previous diagnosis of hypertension by a health professional, and hypertension treatment was defined as undergoing BP treatment.ResultsThe prevalence of hypertension was lower among semiurbanised adults than among non-urbanised rural adults (OR=0.94, 95% CI=0.90 to 0.99; p<0.05). The probabilities of awareness (OR=1.10, 95% CI=1.01 to 1.20; p<0.05) and treatment (OR=1.17, 95% CI=1.08 to 1.26; p<0.001) of hypertension were significantly lower among non-urbanised adults than among urban-born adults. Urbanisation in eastern (OR=0.93, 95% CI=0.88 to 0.99; p<0.05) and western China (OR=1.11, 95% CI=1.01 to 1.23; p<0.05) was associated with the prevalence of hypertension. The urbanisation level was also associated with hypertension awareness and treatment in eastern (OR=1.17, 95% CI=1.04 to 1.32; p<0.01; OR=1.26, 95% CI=1.14 to 1.40; p<0.001), central (OR=1.31, 95% CI=1.05 to 1.63; p<0.05; OR=1.29, 95% CI=1.08 to 1.55; p<0.01) and western China (OR=1.28, 95% CI=1.07 to 1.53; p<0.01; OR=1.34, 95% CI=1.15 to 1.57; p<0.001). The Blinder-Oaxaca decomposition suggested that approximately 42% and 39% of the urban–rural gap in hypertension awareness and treatment, respectively, could be attributed to coefficient difference.ConclusionsPublic health programmes and policies for chronic diseases should adjust with urbanisation and combine individual-centred strategies.
Mental health and working constraints of first-year PhD students in health and science in a French university: a cross-sectional study in the context of occupational health monitoring
Authors: Ahalli Saloua , Fort Emmanuel , Bridai Yamina , Baborier Nicole , Charbotel Barbara 
Published: June 2022

ObjectivesTo assess the mental health and working constraints perception of first-year PhD in France.DesignIt is a cross-sectional study.SettingThe study was conducted by the team of the Lyon 1 University’s Occupational Health and Medical Service for Staff, from October 2019 to February 2020. First-year PhD students employed by the university were seen during the routine occupational health medical check-up.ParticipantsA total of 161 PhD students in science from the 2019 intake were included in the study (participation rate 98%).Outcome measuresData were collected using a self-questionnaire on psychosocial constraints at work (Job Content Questionnaire), the quality of the professional relationship with the supervisor (Advisory Working Alliance Inventory, Student perspective (AWAI-S)), medical conditions, anxiety (Generalized Anxiety Disorder-7) and depressive symptoms (Patient Health Questionnaire-9).ResultsA total of 161 PhD students from the 2019 intake were included in the study (participation rate 98%). Most of the PhD students reported high psychological demands (58%), high decision latitude (53%), high social support (55%) and good professional relationships with their supervisor (mean of global score of AWAI-S=114.5). However, 34% showed signs of at least mild depression, 19% showed signs of anxiety and 20% were referred to a mental health professional after the survey. Bivariate analyses showed that history of psychiatric disorders, their relationship with their supervisor, having complementary teaching activities and stressful working conditions contributed to anxiety and depression.ConclusionsEven in the first year of their PhD, some students had mental health issues. It seems relevant to generalise the medical follow-up of all PhD students as soon as they enter the doctoral programme in order to detect and treat their health problems and psychological disorders at an early stage.
Cross-sectional study of COVID-19 knowledge, beliefs and prevention behaviours among adults in Senegal
Authors: Kearney Matthew , Bornstein Marta , Fall Marieme , Nianogo Roch , Glik Deborah , Massey Philip 
Published: June 2022

ObjectivesThe aim of the study was to explore COVID-19 beliefs and prevention behaviours in a francophone West African nation, Senegal.DesignThis was a cross-sectional analysis of survey data collected via a multimodal observational study.ParticipantsSenegalese adults aged 18 years or older (n=1452).Primary and secondary outcome measuresPrimary outcome measures were COVID-19 prevention behaviours. Secondary outcome measures included COVID-19 knowledge and beliefs. Univariate, bivariate and multivariate statistics were generated to describe the sample and explore potential correlations.SettingParticipants from Senegal were recruited online and telephonically between June and August 2020.ResultsMask wearing, hand washing and use of hand sanitiser were most frequently reported. Social distancing and staying at home were also reported although to a lower degree. Knowledge and perceived risk of COVID-19 were very high in general, but risk was a stronger and more influential predictor of COVID-19 prevention behaviours. Men, compared with women, had lower odds (adjusted OR (aOR)=0.59, 95% CI 0.46 to 0.75, p<0.001) of reporting prevention behaviours. Rural residents (vs urban; aOR=1.49, 95% CI 1.12 to 1.98, p=0.001) and participants with at least a high school education (vs less than high school education; aOR=1.33, 95% CI 1.01 to 1.76, p=0.006) were more likely to report COVID-19 prevention behaviours.ConclusionsIn Senegal, we observed high compliance with recommended COVID-19 prevention behaviours among our sample of respondents, in particular for masking and personal hygiene practice. We also identified a range of psychosocial and demographic predictors for COVID-19 prevention behaviours such as knowledge and perceived risk. Stakeholders and decision makers in Senegal and across Africa can use place-based evidence like ours to address COVID-19 risk factors and intervene effectively with policies and programming. Use of both phone and online surveys enhances representation and study generalisability and should be considered in future research with hard-to-reach populations.
Vulnerability for alcohol use disorder after adverse childhood experiences (AUDACE): protocol for a longitudinal fMRI study assessing neuropsychobiological risk factors for relapse
Authors: Türkmen Cagdas , Machunze Noah , Tan Haoye , Gerhardt Sarah , Kiefer Falk , Vollstädt-Klein Sabine 
Published: June 2022

BackgroundAdverse childhood experiences (ACE) are common and may predispose affected individuals to various health problems, including alcohol use disorder (AUD). Although a relationship between ACE and AUD has been well-established, potential mechanisms that may underlie this relationship remain to be elucidated. The importance of these mechanisms with respect to relapse risk is of particular interest, given the clinical relevance of relapse in addictions. Thus, the aim of this study is to longitudinally assess the role of clinically relevant variables in the relationship between ACE and AUD, namely stress sensitivity, emotion processing, cue reactivity and cognitive functioning (response inhibition and working memory), in relation to relapse risk.Methods and analysisIn this observational, longitudinal case-control study, 36 patients with AUD and heavy drinkers with varying degrees of ACE from a previous project (NCT03758053) as well as newly recruited participants from the same study population will be assessed. Besides measuring long-term relapse in AUD by re-examining these 36 previous participants after 2–2.5 years, factors contributing to short-term relapse will be examined by reassessing all participants on a 3-month follow-up. Furthermore, participants with no or mild ACE will be compared with participants with moderate to severe ACE to assess between-subject differences in risk factors for AUD. Questionnaires and interviews will thus be used to cover individuals’ drinking behaviour and ACE. Emotion processing, stress sensitivity, cue reactivity and cognitive functioning will be assessed using task-based functional MRI (fMRI). Additionally, saliva cortisol and blood samples will be taken to measure hormonal stress response and to perform genome wide association analyses, respectively. The general linear model will be applied on the first level fMRI analyses, whereas for the second level analyses and analyses of behavioural data, t-tests, regression analyses, repeated-measures and one-way analysis of variances will be used.Ethics and disseminationThis study has been approved by the ethics committee of the Medical Faculty Mannheim of Heidelberg University (ethics approval number: 2018-560N-MA with amendment from 29 June 2021). The findings of this study will be presented at conferences and published in peer-reviewed journals.Trial registration numberNCT05048758; Pre-results, clinicaltrials.gov.
Evidence base of economic evaluations of workplace-based interventions reducing occupational sitting time: an integrative review
Authors: Akhavan Rad Sanaz , Kiwanuka Frank , Korpelainen Raija , Torkki Paulus 
Published: June 2022

ObjectiveTo review the evidence on the economic evaluations of workplace-based interventions that are designed to reduce prolonged periods of occupational sitting.DesignAn integrative review.Data sourcesThe search was conducted in 11 databases, including PubMed, Scopus, PsychINFO, NHS-EED, Cumulative Index to Nursing and Allied Health Literature (CINAHL), ProQuest, Cochrane library, Sportdiscus, Research Paper in Economics (RePeC), the International Health Economic Association (IHEA) and EconLit. The databases were searched for articles published from inception to January 2022. Subsequent citation searches were also conducted in Google Scholar. The items of the Consensus Health Economic Criteria (CHEC) checklist were used for quality appraisal of the included studies.ResultsThis review included five randomised control trails, including 757 office-based workers in high-income countries. The median quality appraisal score based on the CHEC items was 14 points (a range of 9–18). The mean duration of interventions was 33 weeks (a range of 4–52 weeks). Overall, the studies reported economic benefit when implemented to reduce occupational sitting time but no effect on absenteeism. From the societal perspective, the interventions (eg, the use of a sit–stand desk) were cost-effective.ConclusionThe economic impact of workplace interventions implemented to reduce occupational sitting time is evident; however, the existing evidence is limited, which precludes strong conclusions. Cost-effectiveness is not often evaluated in the studies exploring workplace interventions that address occupational sitting time. Workplace interventions are still in the development and testing phase; thus, the challenge for future studies is to include economic evaluation of interventions addressing sedentary behaviour in workplaces.PROSPERO registration numberCRD42021226275.
Health system costs of a breast cancer early diagnosis programme in a rural district of Rwanda: a retrospective, cross-sectional economic analysis
Authors: Nambaziira Rashidah , Niteka Lysa Carolle , Dusengimana Jean Marie Vianney , Ruhumuriza John , Bhangdia Kayleigh Pavitra , Mugunga Jean Claude , Uwineza Marie Louise , Rugema Vestine , Erfani Parsa , Shyirambere Cyprien , Shulman Lawrence N , Rabideau Melany , Pace Lydia E 
Published: June 2022

ObjectivesThis study aimed to quantify the health system cost of the first 2 years of a Breast Cancer Early Detection (BCED) programme in a rural district in Rwanda. We also aimed to estimate the cost of implementing the programme in other districts with different referral pathways and identify opportunities for enhanced cost efficiency.DesignRetrospective, cross-sectional analysis using time-driven activity-based costing, based on timed patient clinical encounters, retrospective patient data and unit costs of resources abstracted from administrative and finance records.SettingThe BCED programme focused on timely evaluation of individuals with breast symptoms. The study evaluated the health system cost of the BCED programme at seven health centres (HCs) in Burera district and Butaro Cancer Centre of Excellence (BCCOE) at Butaro District Hospital.Outcome measuresHealth system costs per patient visit and cost per cancer diagnosed were quantified. Total start-up and recurring operational costs were also estimated, as well as health system costs of different scale-up adaptations in other districts.ResultsOne-time start-up costswere US$36 917, recurring operational costswere US$67 711 and clinical costswere US$14 824 over 2 years. Clinical breast examinations (CBE) at HCs cost US$3.27/visit. At BCCOE, CBE-only visits cost US$13.47/visit, CBE/ultrasound US$14.79/visit and CBE/ultrasound/biopsy/pathology US$147.81/visit. Overall, clinical cost per breast cancer diagnosed was US$1482. Clinicalcost drivers were personnel at HCs (55%) and biopsy/pathology supplies at BCCOE (46%). In other districts, patients experience a longer breast evaluation pathway, adding about US$14.00/patient; this could be decreased if ultrasound services were decentralised.ConclusionClinical costs associated with BCED services at HCs were modest, similar to other general outpatient services. The BCED programme’s start-up and operational costs were high but could be reduced by using local trainers and virtual mentorship. In other districts, decentralising ultrasound and/or biopsies to district hospitals could reduce costs.