bluuebunny/crossref_metadata_2025_split huggingface dataset:
Strategies and foundations for scientific discovery in longitudinal studies of bipolar disorder
Authors: McInnis Melvin G. , Andreassen Ole A. , Andreazza Ana C. , Alon Uri , Berk Michael , Brister Teri , Burdick Katherine E. , Cui Donghong , Frye Mark , Leboyer Marion , Mitchell Philip B. , Merikangas Kathleen , Nierenberg Andrew A. , Nurnberger John I. , Pham Daniel , Vieta Eduard , Yatham Lakshmi N. , Young Allan H. 
Published: March 2022

AbstractBipolar disorder (BD) is a complex and dynamic condition with a typical onset in late adolescence or early adulthood followed by an episodic course with intervening periods of subthreshold symptoms or euthymia. It is complicated by the accumulation of comorbid medical and psychiatric disorders. The etiology of BD remains unknown and no reliable biological markers have yet been identified. This is likely due to lack of comprehensive ontological framework and, most importantly, the fact that most studies have been based on small nonrepresentative clinical samples with cross‐sectional designs. We propose to establish large, global longitudinal cohorts of BD studied consistently in a multidimensional and multidisciplinary manner to determine etiology and help improve treatment. Herein we propose collection of a broad range of data that reflect the heterogenic phenotypic manifestations of BD that include dimensional and categorical measures of mood, neurocognitive, personality, behavior, sleep and circadian, life‐story, and outcomes domains. In combination with genetic and biological information such an approach promotes the integrating and harmonizing of data within and across current ontology systems while supporting a paradigm shift that will facilitate discovery and become the basis for novel hypotheses.
COVID‐19: What if immunity wanes?
Authors: Çenesiz M. Alper , Guimarães Luís 
Published: March 2022

AbstractUsing a simple economic model in which social distancing reduces contagion, we study the implications of waning immunity for the epidemiological dynamics and social activity. If immunity wanes, we find that COVID‐19 likely becomes endemic and that social distancing is here to stay until the discovery of a vaccine or cure. But waning immunity does not necessarily change optimal actions on the onset of the pandemic. Decentralized equilibria are virtually independent of waning immunity until close to peak infections. For centralized equilibria, the relevance of waning immunity decreases in the probability of finding a vaccine or cure, the costs of infection (e.g., infection–fatality rate), the degree of partial immunity and the presence of other NPIs that lower contagion (e.g., quarantining and mask use). In simulations calibrated to July 2020, our model suggests that waning immunity is virtually unimportant for centralized equilibria until at least 2021. This provides vital time for individuals and policy‐makers to learn about immunity against SARS‐CoV‐2 before it becomes critical.
Temporal cortex activation explains children’s improvement in math attitudes
Authors: Suárez‐Pellicioni Macarena , Booth James R. 
Published: March 2022

AbstractMath attitudes are related to achievement, yet we do not know how the brain supports changes in math attitudes. 51 children (54.9% female, 45.1% male; 37.3% White, 33.3% Black, 11.8% Latino, 5.9% Asian, 11.8% Other) solved a multiplication task inside the scanner when they were approximately 11 (time 1; T1) and 13 (time 2; T2) years old (i.e., mean age). Results revealed clusters in the left middle to superior temporal gyri at T1 associated with math attitudes at T1 and with their longitudinal improvement. However, changes in attitudes were not associated with brain changes over time. These findings suggest that relying on the storage of arithmetic facts, involved in memory retrieval, explains the development of positive math attitudes.
From synapses to circuits and back: Bridging levels of understanding in animal models of Alzheimer's disease
Authors: Chockanathan Udaysankar , Padmanabhan Krishnan 
Published: March 2022

AbstractAlzheimer's disease (AD) is a neurodegenerative disorder characterized by behavioural changes that include memory loss and cognitive decline and is associated with the appearance of amyloid‐β plaques and neurofibrillary tangles throughout the brain. Although aspects of the disease percolate across multiple levels of neuronal organization, from the cellular to the behavioural, it is increasingly clear that circuits are a critical junction between the cellular pathology and the behavioural phenotypes that bookend these levels of analyses. In this review, we discuss critical aspects of neural circuit research, beginning with synapses and progressing to network activity and how they influence our understanding of disease processed in AD.
Thought and reality in Marx's early writings on ancient philosophy
Authors: Schuringa Christoph 
Published: March 2022

AbstractThere is little agreement about Marx's aims, or even his basic claims, in his Notebooks on Epicurean Philosophy and Difference Between the Democritean and Epicurean Philosophy of Nature. Marx has been read as an idealist, or as a materialist; as praising Epicurus, or as criticizing him. Some have read Marx as using ancient philosophers as proxies in a contemporary debate, without demonstrating how he does so in detail. I show that Marx's dialectical reading of Epicurus's atomism aims at transcending the dichotomy between idealism and materialism; that on Marx's reading Epicurus deserves praise for thinking through atomism to its “highest” conclusion, but criticism for not embracing this conclusion; and that Marx's intervention in contemporary debates takes the form of revealing a dialectical relationship between “liberal” and “positive” philosophers. I conclude that the importance of these texts is to be located in their original stance on the problematic of the relation of thought to reality, common to what Marx finds in ancient philosophy and in his contemporary environment.
RETRACTED: The analysis of optimized path selection for management mode of coastal regional circular economy based on fuzzy decision algorithm
Authors: Wei Wenwan , Xiao De , Liu Wan 
Published: March 2022

AbstractIn order to achieve economic growth without destroying the environment and consuming resources, it is necessary to reasonably predict the development trend of circular economy. The evolution path of circular economy in the coastal regions was analysed based on the fuzzy technique for order of preference by similarity to ideal solution (TOPSIS) method. The dynamic investigation was carried out through the variations of moving trajectory of model space points in a certain period of time, the evolution path of circular economy development in coastal regions was numerically simulated to conclude the evolution law of sustainable growth path in coastal regions, and the future development trend of coastal regional circular economy was predicted. Finally, the composite indicator is synthesized accordingly as an example to quantify the development of the Center of around Bohai Sea Economic Rim (BER). On the basis of introducing the basic situation of BER as well as its circular economy development status, comprehensive economic performance dataset of BER from 2005 to 2018 is used with specified TOPSIS method to improve the accuracy of evaluation. In addition, on the basis of the rule, the future development direction of the circular economy of the BER was predicted, and the policy suggestions were put forward in view of the development status and problems of circular economy.
Methane production controls in a young thermokarst lake formed by abrupt permafrost thaw
Authors: Pellerin André , Lotem Noam , Walter Anthony Katey , Eliani Russak Efrat , Hasson Nicholas , Røy Hans , Chanton Jeffrey P. , Sivan Orit 
Published: March 2022

AbstractMethane (CH4) release to the atmosphere from thawing permafrost contributes significantly to global CH4 emissions. However, constraining the effects of thaw that control the production and emission of CH4 is needed to anticipate future Arctic emissions. Here are presented robust rate measurements of CH4 production and cycling in a region of rapidly degrading permafrost. Big Trail Lake, located in central Alaska, is a young, actively expanding thermokarst lake. The lake was investigated by taking two 1 m cores of sediment from different regions. Two independent methods of measuring microbial CH4 production, long term (CH4 accumulation) and short term (14C tracer), produced similar average rates of 11 ± 3.5 and 9 ± 3.6 nmol cm−3 d−1, respectively. The rates had small variations between the different lithological units, indicating homogeneous CH4 production despite heterogeneous lithology in the surface ~1 m of sediment. To estimate the total CH4 production, the CH4 production rates were multiplied through the 10–15 m deep talik (thaw bulb). This estimate suggests that CH4 production is higher than emission by a maximum factor of ~2, which is less than previous estimates. Stable and radioactive carbon isotope measurements showed that 50% of dissolved CH4 in the first meter was produced further below. Interestingly, labeled 14C incubations with 2‐14C acetate and 14C CO2 indicate that variations in the pathway used by microbes to produce CH4 depends on the age and type of organic matter in the sediment, but did not appear to influence the rates at which CH4 was produced. This study demonstrates that at least half of the CH4 produced by microbial breakdown of organic matter in actively expanding thermokarst is emitted to the atmosphere, and that the majority of this CH4 is produced in the deep sediment.
Towards identifying industrial crop types and associated agronomies to improve biomass production from marginal lands in Europe
Authors: Scordia Danilo , Papazoglou Eleni G. , Kotoula Danai , Sanz Marina , Ciria Carlos S. , Pérez Javier , Maliarenko Oksana , Prysiazhniuk Oleh , von Cossel Moritz , Greiner Beatrice E. , Lazdina Dagnija , Makovskis Kristaps , Lamy Isabelle , Ciadamidaro Lisa , Petit‐dit‐Grezeriat Lucas , Corinzia Sebastiano A. , Fernando Ana L. , Alexopoulou Efthymia , Cosentino Salvatore L. 
Published: March 2022

AbstractGrowing industrial crops on marginal lands has been proposed as a strategy to minimize competition for arable land and food production. In the present study, eight experimental sites in three different climatic zones in Europe (Mediterranean, Atlantic and Continental), seven advanced industrial crop species [giant reed (two clones), miscanthus (M. × giganteus and two new seed‐based hybrids), saccharum (one clones), switchgrass (one variety), tall wheatgrass (one variety), industrial hemp (three varieties) and willow (eleven clones)], and six marginality factors alone or in combination (dryness, unfavorable texture, stoniness, shallow soil, topsoil acidity, heavy metal and metalloid contamination) were investigated. At each site, biophysical constraints and low‐input management practices were combined with prevailing climatic conditions. The relative yield of a site‐specific low‐input system compared with the site‐specific control was from small to large (i.e. from −99% in industrial hemp in the Mediterranean to +210% in willow in the Continental zone), due to the genotype‐by‐management interaction along with climatic variation between growing seasons. Genotype selection and improved knowledge on crop response to changing environmental, site‐specific biophysical constraint and input application has been detected as key to profitably grow industrial crops on marginal areas. This study may act to provide hints on how to scale up investigated cropping systems, through low‐input practices, under similar environmental and soil conditions tested at each site. However, further attention to detail on the agronomy of early plant development and management in larger multi‐year and multi‐location field studies with commercially scalable agronomies are needed to validate yield performances, and thereby to inform on the best industrial crop options.
Re‐valuation of annual cytology using HPV self‐sampling to upgrade prevention (REACH UP): A feasibility study in women living with HIV in the UK
Authors: Cicconi Paola , Wells Charlotte , McCarthy Blanka , Wareing Susan , Andersson Monique Ingrid , Fox Julie , Lwanga Julianne , Pal Nisha , Burns Fiona , Woodward Clare , Malek Ramona , Sabin Caroline Anne , Dorrell Lucy 
Published: March 2022

AbstractIntroductionCurrent UK guidelines for cervical cancer screening are based on the assumption that most women living with HIV (WLWH) are also high‐risk (HR) human papillomavirus (HPV)‐positive. We aimed to provide data on prevalence of HR‐HPV in WLWH in the UK and to assess feasibility and acceptability of HR‐HPV self‐sampling in this group.MethodsWomen living with HIV attending six HIV services in London/south of England, with no history of cervical cancer, were enrolled. Participants self‐collected a vaginal swab for the detection of HR‐HPV, completed a survey about sexual/gynaecological history, attitudes towards annual screening and perception of HR‐HPV self‐sampling, and were asked to have their annual cervical smear.ResultsIn all, 67 women were included: 86.5% were of black ethnicity, the median (range) age was 47 (24–60) years, median CD4 T‐cell count was 683 cells/µL [interquartile range (IQR): 527–910], and 95.4% had viral load ≤ 50 copies/mL. All performed the vaginal swab. Eighteen (27%) had no cervical smear results; none of these women attended HIV services where this was routinely offered. No cervical samples were positive for HR‐HPV. Three‐quarters (75.8%) of participants reported adherence to annual screening, with only one woman (1.5%) attending irregularly. On visual analogue scales (from 0 to 100), median (IQR) acceptability and necessity of smear tests were 100 (75–100) and 100 (85–100), respectively.ConclusionsOur results suggest that the prevalence of HR‐HPV in WLWH in the UK may be low. Self‐sampling seems to be acceptable, suggesting, if validated, its potential role in supporting less frequent smear testing and improving screening uptake in WLWH.
The prevalence of Campylobacter spp., Listeria monocytogenes and Shiga toxin-producing Escherichia coli in Norwegian dairy cattle farms: A comparison between free stall and tie stall housing systems
Authors: Idland Lene , Granquist Erik G. , Aspholm Marina , Lindbäck Toril 
Published: March 2022

AbstractAimsThis study explored how dairy farm operating systems with free-stall or tie-stall housing and cow hygiene score influence the occurrence of zoonotic bacteria in raw milk.Methods and ResultsSamples from bulk tank milk (BTM), milk filters, faeces, feed, teats and teat milk were collected from 11 farms with loose housing and seven farms with tie-stall housing every second month over a period of 11 months and analysed for the presence of STEC by culturing combined with polymerase chain reaction and for Campylobacter spp. and L. monocytogenes by culturing only. Campylobacter spp., L. monocytogenes and STEC were present in samples from the farm environment and were also detected in 4%, 13% and 7% of the milk filters, respectively, and in 3%, 0% and 1% of BTM samples. Four STEC isolates carried the eae gene, which is linked to the capacity to cause severe human disease. L. monocytogenes were detected more frequently in loose housing herds compared with tie-stalled herds in faeces (p = 0.02) and feed (p = 0.03), and Campylobacter spp. were detected more frequently in loose housing herds in faeces (p &lt; 0.01) and teat swabs (p = 0.03). An association between cow hygiene score and detection of Campylobacter spp. in teat milk was observed (p = 0.03).ConclusionSince some samples collected from loose housing systems revealed a significantly higher (p &lt; 0.05) content of L. monocytogenes and Campylobacter spp. than samples collected from tie-stalled herds, the current study suggests that the type of housing system may influence the food safety of raw milk.Significance and Impact of the StudyThis study highlights that zoonotic bacteria can be present in raw milk independent of hygienic conditions at the farm and what housing system is used. Altogether, this study provides important knowledge for evaluating the risk of drinking unpasteurized milk.
Nurse‐led interventions to manage hypertension in general practice: A systematic review and meta‐analysis
Authors: Stephen Catherine , Halcomb Elizabeth , Fernandez Ritin , McInnes Susan , Batterham Marijka , Zwar Nick 
Published: March 2022

AbstractTo evaluate the impact of general practice nurse‐led interventions for blood pressure control and cardiovascular disease risk factor reduction in patients with hypertension. Systematic review and meta‐analysis of randomized control trials. CINAHL, Medline and Scopus databases were searched to identify peer‐reviewed studies published between 2000 and 2021. A systematic review of randomized control trials was conducted using a structured search strategy. The Meta‐Analysis of Statistics Assessment and Review Instrument (JBI‐MAStARI) was used to appraise study quality. Meta‐analysis and narrative synthesis were performed to determine the effectiveness of the included interventions. Eleven trials comprising of 4454 participants were included in the review. Meta‐analysis showed significant reductions in both systolic and diastolic blood pressure in trials with 6 months or less follow‐up. Improvements were also demonstrated in reducing blood lipids, physical activity, general lifestyle measures and medication adherence. Evidence for dietary improvements and reduction in alcohol and smoking rates was inconclusive. Nurse‐led interventions for patients with hypertension are heterogeneous in terms of the nature of the intervention and outcomes measured. However, nurse‐led interventions in general practice demonstrate significant potential to improve blood pressure and support cardiovascular disease risk factor reduction. Future research should be directed towards elucidating the successful elements of these interventions, evaluating cost‐effectiveness and exploring translation into usual care. This review provides evidence that nurses in general practice could enhance current hypertension management through nurse‐led interventions.
Association between biventricular pacing and incidence of ventricular arrhythmias in the early post‐operative period after left ventricular assist device implantation
Authors: Chou Andrew , Larson John , Deshmukh Amrish , Cascino Thomas M. , Ghannam Michael , Latchamsetty Rakesh , Jongnarangsin Krit , Oral Hakan , Morady Fred , Bogun Frank , Aaronson Keith D. , Pagani Francis D. , Liang Jackson J. 
Published: March 2022

AbstractIntroductionCardiac resynchronization therapy (CRT) and left ventricular assist devices (LVAD) improve outcomes in heart failure patients. Early ventricular arrhythmias (VA) are common after LVAD and are associated with increased mortality. The association between left ventricular pacing (LVP) with CRT and VAs in the early post‐LVAD period remains unclear.MethodsThis was a retrospective study of all patients undergoing LVAD implantation from 1/2016 to 12/2019. Patients were divided into those with CRT and active LVP (CRT‐LVP) immediately post‐LVAD implant versus those without CRT‐LVP. Implantable cardiac defibrillator electrograms were reviewed and early VAs were defined as sustained ventricular tachycardia (VT)/ventricular fibrillation occurring within 30 days of LVAD implantation.ResultsOf 186 included patients (mean age 53 years, 75% male, mean body mass index 28), 72 had CRT devices, 63 of whom had LV pacing enabled after LVAD implant (CRT‐LVP group). Patients with CRT‐LVP were more likely to have VA in the early postoperative period (21% vs. 4%; p = .0001). All 9 patients with CRT in whom LVP was disabled had no early VA. Among those with early VA, patients with CRT‐LVP were more likely to have monomorphic VT (77% vs. 40%; p = .07). In multiple logistic regression, CRT‐LVP pacing remained an independent predictor of early VA after adjustment for history of VA and AF.ConclusionsPatients with CRT‐LVP after LVAD implant had a higher incidence of early VA (specifically monomorphic VT). Epicardial LV pacing may be proarrhythmic in the early postoperative period after LVAD.
Reduction in cardiovascular disease events in patients with type 2 diabetes mellitus treated with a sodium–glucose cotransporter 2 inhibitor versus a dipeptidyl peptidase‐4 inhibitor: A real‐world retrospective administrative database analysis in Japan
Authors: Kashiwagi Atsunori , Shoji Shingo , Onozawa Satoshi , Kosakai Yoshinori , Waratani Miina , Ito Yuichiro 
Published: March 2022

AbstractAims/IntroductionTo evaluate the benefit of sodium–glucose cotransporter 2 inhibitors (SGLT2i) versus dipeptidyl peptidase‐4 inhibitors (DPP4i) in reducing cardiovascular disease (CVD) events in patients with type 2 diabetes mellitus with and without a CVD history.Materials and MethodsThis retrospective cohort study used Japanese hospital administrative data from the Medical Data Vision database (January 2015 to April 2020). Patients with type 2 diabetes mellitus (n = 625,739) who were new users of an SGLT2i (n = 57,070; 9.1%) or DPP4i (n = 568,669; 90.9%) were included. Outcomes included hospitalization for heart failure (hHF), all‐cause death (ACD) and the composite of hHF or ACD. Hazard ratios (HR) were calculated using the inverse probability weighting Cox proportional hazards model to compare CVD event risks between treatment groups.ResultsCompared with DPP4i, SGLT2i was associated with a significant reduction in hHF risk among patients without a CVD history (HR 0.507, 95% confidence interval 0.283–0.907), but not in the full cohort or those with a CVD history. SGLT2i was associated with a significant risk reduction of ACD (HR 0.592, 95% confidence interval 0.481–0.729) and the composite of hHF or ACD (HR 0.712, 95% confidence interval 0.613–0.826), compared with DPP4i in the full cohort; similar results were observed among patients with and without a CVD history.ConclusionsIn this real‐world study, SGLT2i versus DPP4i was associated with a significant reduction in hHF, ACD and hHF or ACD events in patients with type 2 diabetes mellitus without a CVD history.
The first description of larvae and comments on the taxonomy of Stichaeus ochriamkini Taranetz, 1935 (Perciformes: Stichaeidae)
Authors: Balanov Andrey A. , Epur Irina V. , Shelekhov Vladimir A. , Turanov Sergey V. 
Published: March 2022

AbstractStichaeus ochriamkini (Stichaeidae) is common in the northern Japan Sea and the southern Okhotsk Sea. Among the five known representatives of the genus Stichaeus, early ontogenesis is the least studied in S. ochriamkini. In this study, the authors provide the first description of all larval stages of this species. In the north‐western Japan Sea, larvae are found in plankton from early April to early June. S. ochriamkini larvae can be identified using the following characters: postanal‐lateral pigment (PLP) lines present on the sides of the caudal part of the body and run along the anterior edge of hypaxial myomeres; 14–15 abdominal vertebrae; 32–34 rays in the anal fin; larvae disappear from plankton at a body length of LT > 25.0 mm (LS > 20 mm). Larvae of S. ochriamkini are very similar to larvae of Stichaeus punctatus. The melanin pigmentation in larvae of both species shows similar patterns of development. In the genus Stichaeus Reinhardt, 1836, two groups of species are distinguished by the presence/absence of PLP lines in larvae, and by significant divergence (clearly exceeding the species level) in the COI mtDNA gene. It is suggested the differences between these species groups is recognized at the generic level. Thus, the genus Stichaeus Reinhardt, 1836 should include S. punctatus and S. ochriamkini, whereas the other three species should be placed in the genus Dinogunellus Herzenstein, 1890: Dinogunellus fuscus, Dinogunellus nozawae and Dinogunellus grigorjewi.