bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of assessment methods on the determination of the critical wind speeds of high-speed trains
Authors: Yang Shiwei , Liu Rong , Liu Dongrun 
Published: September 2022

Abstract
Critical wind speed can play an important guiding role in developing an initial train operation schedule and knowledge of it may prevent safety risks for a train. Hence, the efficient and accurate calculation of the critical wind speeds of trains is critical. This study addresses this topic and focuses on the influence of different methods on the calculation of the critical wind speed. The result reveals that the five-mass and three-mass methods can both be used to determine the critical wind speed of a train more quickly with acceptable accuracy, but these two methods overestimate the crosswind safety risk of the train. With the increase of the train's operating speed, the nonlinearity of the vehicle system is further enhanced. In particular, the influence of the rolling motion between the car body and the bogie is more prominent, and the results of the five-mass method and the multi-body simulation method tend to be the closest. Last but not least, the damping parameters and inertial forces ignored by the quasi-static method will effectively reduce the wind forces transmitted to the track, resulting in a smaller overturning coefficient and higher critical wind speed.
First molecular phylogeny of the freshwater planarian genusGirardia(Platyhelminthes: Tricladida) unveils hidden taxonomic diversity and initiates resolution of its historical biogeography
Authors: Benítez-Álvarez Lisandra , Sluys Ronald , Leal-Zanchet Ana María , Leria Laia , Riutort Marta 
Published: September 2022

AbstractThe genus Girardia (Platyhelminthes: Tricladida) comprises several species of which some have spread from their original areas of distribution in the Americas to other parts of the globe. Due to great anatomical similarity between species, morphology-based phylogenetic analyses have struggled to resolve the affinities between species and species-groups. This problem is exacerbated by the fact that populations of Girardia may show only asexual reproduction by fissiparity and, thus, do not exhibit a copulatory apparatus, which hampers taxonomic identification of phylogenetic characters. In the present work, this problem has been resolved by constructing a molecular phylogeny of the genus. Although our samples do not include representatives of all known species, they cover a large part of the original distributional range of the genus Girardia. Our phylogenetic results suggest the presence of two main clades, which are genetically and karyologically highly differentiated. North and South American populations of G. tigrina actually constitute two sibling species that are not even closely related. The South American form is here described as a new species. The phylogenetic tree brings to light that Girardia arose on the South American portion of Gondwanaland, from which it, subsequently, dispersed to the Nearctic Region, probably more than once.
Assessing Resident Well-Being After the ABSITE: A Bad Time to Ask?
Authors: Cheung Elaine O. , Hu Yue-Yung , Jones Andrew , Ma Meixi , Schlick Cary Jo R. , Moskowitz Judith T. , Agarwal Gaurava , Bilimoria Karl Y. 
Published: September 2022

Objectives:
Assess the association of residents’ exam performance and transient emotions with their reports of burnout, suicidality, and mistreatment.

Background:
An annual survey evaluating surgical resident well-being is administered following the American Board of Surgery In-Training Examination (ABSITE). One concern about administering a survey after the ABSITE is that stress from the exam may influence their responses.

Methods:
A survey was administered to all general surgery residents following the 2018 ABSITE assessing positive and negative emotions (scales range from 0 to 12), as well as burnout, suicidality over the past 12 months, and mistreatment (discrimination, sexual harassment verbal/emotional or physical abuse) in the past academic year. Multivariable hierarchical regressions assessed the associations of exam performance and emotions with burnout, suicidality, and mistreatment.

Results:
Residents from 262 programs provided complete responses (N = 6987, 93.6% response rate). Residents reported high mean positive emotion (M = 7.54, SD = 2.35) and low mean negative emotion (M = 5.33, SD = 2.43). While residents in the bottom ABSITE score quartile reported lower positive and higher negative emotion than residents in the top 2 and 3 quartiles, respectively (P < 0.005), exam performance was not associated with the reported likelihood of burnout, suicidality, or mistreatment.

Conclusions:
Residents’ emotions after the ABSITE are largely positive. Although poor exam performance may be associated with lower positive and higher negative emotion, it does not seem to be associated with the likelihood of reporting burnout, suicidality, or mistreatment. After adjusting for exam performance and emotions, mistreatment remained independently associated with burnout and suicidality. These findings support existing evidence demonstrating that burnout and suicidality are stable constructs that are robust to transient stress and/or emotions.
Displaced Tibia Fractures in Adolescents: Closed Reduction and Casting Versus Flexible Intramedullary Nails
Authors: Rivera Asdrubal E. , Cummings Jason L. , Pereira Daniel E. , Oladeji Afolayan K. , Landau Andrew J. , Hosseinzadeh Pooya 
Published: September 2022

Introduction:
Although there has been a recent trend towards the operative intervention of pediatric diaphyseal tibial fractures, there is sparse literature that supports this trend. This study compares the outcomes in children between 10 and 18 years of age with diaphyseal tibial fractures who undergo nonoperative treatment with closed reduction and casting (CRC) to those who undergo operative treatment with flexible intramedullary nailing.

Methods:
A retrospective chart review was performed of all patients between 10 and 18 years of age who underwent treatment for tibia fractures at the authors home institution between 2005 and 2018. Radiographs and medical records were reviewed for the duration of immobilization, time to fracture healing and complications including delayed union, malunion, nonunion, and surgical site infection. All statistical analysis was performed using an αof 0.05.

Results:
One hundred forty one patients (81.8% males) were included in the final analysis. Patients treated with flexible nailing took an average of 7 weeks (P<0.001) longer than patients treated with CRC to achieve radiographic healing. The average time to full weight-bearing activities was longer by 1 week in the patients treated nonoperatively with CRC (P=0.001). There was no statistically significant difference in the malunion rates between the 2 groups (P=0.067), but delayed union and nonunion were exclusively seen in the flexible nailing group. There was a total of 40 complications among 33 (23.4%) patients, most of whom were in the CRC cohort (60.6%, n=20), but there was no statistically significant difference in complication rates between the 2 cohorts.

Discussion:
Most adolescents presenting with closed diaphyseal tibial fractures of moderate severity can be successfully treated both nonoperatively with CRC and operatively with flexible intramedullary nailing. However, we recommend an initial attempt at nonoperative treatment be performed in these patients due to the association of more severe complications with flexible nailing.

Level of Evidence:
Level III.
Evaluation of Xenograft Efficacy in Immediate Prosthesis-based Breast Reconstruction
Authors: Sobti Nikhil , Vishwanath Neel , King Victor A. , Rao Vinay , Rhee Ben , Spake Carole S.L. , Borrelli Mimi R. , Akiki Ronald A. , Breuing Karl H. 
Published: September 2022

Background:
The advent of acellular dermal matrix (ADM) has revolutionized prosthesis-based breast reconstruction. However, paucity of human cadaveric tissue has resulted in limitation of supply and increased associated costs, prompting concerted effort to identify xenograft alternatives. Although studies have examined the safety of Artia, a porcine-derived ADM, few have evaluated its clinical efficacy as soft tissue reinforcement. This study uniquely evaluates the clinical efficacy of Artia in implant-based breast reconstruction.

Methods:
IRB-approved retrospective chart review was conducted to identify 243 consecutive TE-based procedures performed at a tertiary academic medical center between March 2017 and March 2021. Propensity matching was conducted to minimize differences between cohorts. Efficacy metrics, defined as initial tissue expander (TE) fill volume, number of TE fills, and time interval between exchange of TE for final implant, were compared between xenograft (Artia) and allograft (AlloDerm) groups.

Results:
Patients who underwent Artia-based breast reconstruction achieved superior initial TE fill volume relative to those who underwent AlloDerm-based breast reconstruction via univariate analysis (317.3 ± 185.8 mL versus 286.1 ± 140.4 mL, P < 0.01) when patient and operative characteristics were well-matched. However, linear regression analysis failed to demonstrate difference in efficacy metrics, such as initial TE fill volume (P = 0.31), ratio between initial TE fill volume and final implant size (P = 0.19), and number of TE fills (P = 0.76). Complication rates were comparable between groups.

Conclusion:
This study suggests that Artia can be used as a safe and efficacious alternative to human-derived ADM in immediate TE-based breast reconstruction.
An Account From a Sexual Assault Nurse Examiner on Caring for a Transgender Survivor: A Case Report
Authors: Alcock Mallory , Hilario Carla T. , MacLennan D. Stewart 
Published: September 2022

ABSTRACT
Transgender individuals represent a gender minority population that has been underserved within the healthcare system and underrepresented in population health and sexuality research, specifically as it pertains to sexual assault. This case report aims to explore how sexual assault nurse examiners (SANEs) approach the care of transgender people who have survived sexual assault. Key components and findings related to the SANE's encounter will be examined including an evaluation of the biases and assumptions held by the SANE and other healthcare providers. Concepts such as cisnormativity, heteronormativity, and intersectionality will be examined in terms of how these can shape the experience of the survivor, influence the care provided by SANEs, and interact with gender stereotypes and nonaffirming practices faced by transgender people. This case report highlights the importance of acknowledging and undermining nursing approaches that can (re)traumatize sexual assault survivors and explores ways in which SANEs can help to shift views of gender and bodies with the goal of providing better care for gender minority populations.
Qualitative Analysis Using Social Maps to Explore Young Women's Experiences With Social Support of their Oral PrEP Use in Kenya and South Africa
Authors: Katz Ariana W. K. , Roberts Sarah , Rousseau Elzette , Khoza Makhosazane Nomhle , Mogaka Felix , Bukusi Elizabeth , Delany-Moretlwe Sinead , Bekker Linda-Gail , Morton Jennifer F. , Johnson Rachel , Baeten Jared M. , Celum Connie , van der Straten Ariane 
Published: September 2022

Abstract
Daily oral pre-exposure prophylaxis (PrEP) adherence is challenging. We explored African adolescent girls and young women's (AGYW) perceptions of the social influencers of their PrEP use and the social influencers' PrEP knowledge and support (six focus group discussions; 33 South African and Kenyan AGYW) in the Prevention Options for Women Evaluation Research demonstration project. Participants completed a social mapping exercise indicating strength and direction of influence of members in their social networks. Mothers and counselors were identified as positive influencers and most influential by >50% of participants, sex partners were labeled negative influencers or both positive and negative, and best friends were mostly positive influencers. HIV- and PrEP-related stigma were the major reasons influencers were identified as negative. Participants wanted their social networks to be better educated about PrEP by someone other than the AGYW themselves (e.g., clinic staff) and to support their PrEP use. To improve PrEP adherence, community- and peer-based PrEP sensitization and delivery interventions should be evaluated.
Artificial Intelligence Confirming Treatment Success: The Role of Gender- and Age-Specific Scales in Performance Evaluation
Authors: Georgievskaya Anastasia 
Published: September 2022

Summary:
In plastic surgery and cosmetic dermatology, photographic data are an invaluable element of research and clinical practice. Additionally, the use of before and after images is a standard documentation method for procedures, and these images are particularly useful in consultations for effective communication with the patient. An artificial intelligence (AI)-based approach has been proven to have significant results in medical dermatology, plastic surgery, and antiaging procedures in recent years, with applications ranging from skin cancer screening to 3D face reconstructions, the prediction of biological age and perceived age. The increasing use of AI and computer vision methods is due to their noninvasive nature and their potential to provide remote diagnostics. This is especially helpful in instances where traveling to a physical office is complicated, as we have experienced in recent years with the global coronavirus pandemic. However, one question remains: how should the results of AI-based analysis be presented to enable personalization? In this paper, the author investigates the benefit of using gender- and age-specific scales to present skin parameter scores calculated using AI-based systems when analyzing image data.
Partial Glossectomy Combined With Radiofrequency Ablation for Macroglossia in Beckwith-Wiedemann Syndrome
Authors: Lan Dongyi , Gao Xingqiang , Zhang Songchunyuan , Li Jun , Dong Chenbin 
Published: September 2022

Objective:As the most common feature of Beckwith-Wiedemann syndrome (BWS), macroglossia may influence the quality of life, maxillofacial growth, and speech development of children. The retrospective study aimed to investigate the therapeutic effect of partial glossectomy combined with radiofrequency ablation (RFA) for macroglossia patients in BWS.Methods:A retrospective study was conducted in BWS-derived macroglossia patients who underwent partial glossectomy combined with RFA from May 2019 to January 2021. In total, 35 patients consisting of 17 males and 18 females met the inclusion criteria and underwent surgery by the same plastic surgeon. Demographic characteristics, BWS features, operation details, preoperative and postoperative outcomes, satisfaction evaluations, and subgroup analysis were collected and assessed.Results:Of the 35 patients involved, the average age at the time of surgery was 14.05±8.08 months, and the average surgery duration was 48.17±6.72 minutes. Only 1 patient suffered ventral tongue wound dehiscence, and the rest of the patients did not develop any other complications. The severity and frequency of tongue protrusion, drooling, snoring, and feeding difficulty were significantly ameliorated. The patient’s parents showed satisfaction towards the overall surgery, tongue’s appearance, and tongue’s motor function. Tongue’s height decreased from 32.09±1.16 mm before the operation to 29.29±1.33 mm after the operation.Conclusion:The partial glossectomy combined RFA exerts a safe, effective and viable technique to treat BWS-derived macroglossia.
Phase-Amplitude Coupling in Autism Spectrum Disorder: Results from the Autism Biomarkers Consortium for Clinical Trials
Authors: Peck Fleming , Naples Adam J. , Webb Sara J. , Bernier Raphael A. , Chawarska Katarzyna , Dawson Geraldine , Faja Susan , Jeste Shafali , Murias Michael , Nelson Charles A. , Shic Frederick , Sugar Catherine , Şentürk Damla , McPartland James C. , Levin April R. ,   the ABC-CT Network
Published: September 2022

AbstractBackgroundAutism spectrum disorder (ASD) is defined behaviorally, but measures that probe underlying neural mechanisms may provide clues to biomarker discovery and brain-based patient stratification with clinical utility. Phase-amplitude coupling (PAC) has been posited as a measure of the balance between top-down and bottom-up processing in cortex, as well as a marker for sensory processing and predictive coding difficulties in ASD. We evaluate differences in PAC metrics of resting-state brain dynamics between children with and without ASD and relate PAC measures to age and behavioral assessments.MethodsWe analyzed electroencephalography data collected by the Autism Biomarkers Consortium for Clinical Trials, including 225 (192 male) ASD and 116 (81 male) typically-developing children aged 6-11 years. We evaluated the strength and phase preference of PAC and the test-retest reliability of PAC across sessions.ResultsThere was significantly increased alpha-gamma and theta-gamma PAC strength in ASD. When considering all participants together, we found significant associations of whole brain theta-gamma PAC strength with measures of social communication (Beta = 0.185; p = 0.006) and repetitive behaviors (Beta = 0.166; p = 0.009) as well as age (Beta = 0.233; p < 0.0001); however, these associations did not persist when considering the ASD group alone. There are also group differences in theta-gamma phase preference.ConclusionsThis large, rigorously collected sample indicated altered PAC strength and phase bias in ASD. These findings suggest opportunities for back-translation into animal models as well as clinical potential for stratification of brain-based subgroups in ASD.
Impact of Differential Vaccine Effectiveness on COVID-19 Hospitalization Cases: Projections for 10 Developed Countries where Booster Vaccines were Recommended
Authors: Maschio Michael , Fust Kelly , Lee Amy , Van de Velde Nicolas , Buck Philip O. , Kohli Michele A. 
Published: September 2022

ABSTRACTBackground & ObjectivesIn a previous analysis, a decision-analytic model was used to analyze the clinical and economic impact of the differences in effectiveness between the two licensed mRNA COVID-19 booster vaccines, mRNA-1273 and BNT162b2, in 2022 for adults aged 18 years and older in the United States (US). In this analysis, the same model was used to estimate the impact that administering first booster doses with mRNA-1273 could have had on COVID-related hospitalizations and costs over a 6-month period in 10 developed countries (Australia, Canada, France, Germany, Italy, Japan, South Korea, Spain, United Kingdom [UK], and US), considering updated effectiveness data.MethodsThe model was used to estimate number of hospitalizations and related costs using the actual vaccine distribution for the first COVID-19 booster from each country. These estimates were compared to a scenario where 100% of doses for that 6-month period was assumed to be mRNA-1273. The effectiveness of mRNA-1273 compared to BNT162b2 was estimated from real world data from the UK.ResultsThe total number of doses switched to the mRNA-1273 booster would range from 4.3 million in Spain to 39.4 million in Japan. The number of hospitalizations and associated hospitalization costs would be expected to fall in all countries, with the proportional decrease ranging from 1.1% (16,800 fewer) in Germany to 8.8% (25,100 fewer) in Australia.ConclusionsReal-world effectiveness data suggest that a booster dose of the mRNA-1273 vaccine may be more effective compared to other vaccines used for booster doses. Given this difference in effectiveness, results of this analysis demonstrate that switching to 100% mRNA-1273 boosters would have reduced the number of hospitalizations and associated costs in each country during the first 6 months of the omicron period.
The Quartet Data Portal: integration of community-wide resources for multiomics quality control
Authors: Yang Jingcheng , Liu Yaqing , Shang Jun , Chen Qiaochu , Chen Qingwang , Ren Luyao , Zhang Naixin , Yu Ying , Li Zhihui , Song Yueqiang , Yang Shengpeng , Scherer Andreas , Tong Weida , Hong Huixiao , Shi Leming , Xiao Wenming , Zheng Yuanting 
Published: September 2022

AbstractThe implementation of quality control for multiomic data requires the widespread use of well-characterized reference materials, reference datasets, and related resources. The Quartet Data Portal was built to facilitate community access to such rich resources established in the Quartet Project. A convenient platform is provided for users to request the DNA, RNA, protein, and metabolite reference materials, as well as multi-level datasets generated across omics, platforms, labs, protocols, and batches. Interactive visualization tools are offered to assist users to gain a quick understanding of the reference datasets. Crucially, the Quartet Data Portal continuously collects, evaluates, and integrates the community-generated data of the distributed Quartet multiomic reference materials. In addition, the portal provides analysis pipelines to assess the quality of user-submitted multiomic data. Furthermore, the reference datasets, performance metrics, and analysis pipelines will be improved through periodic review and integration of multiomic data submitted by the community. Effective integration of the evolving technologies via active interactions with the community will help ensure the reliability of multiomics-based biological discoveries. The Quartet Data Portal is accessible athttps://chinese-quartet.org.Graphical Abstract
Perplexity about periodicity repeats perpetually: A response to Brookshire
Authors: Re Daniele , Tosato Tommaso , Fries Pascal , Landau Ayelet N. 
Published: September 2022

AbstractBrookshire (2022) claims that previous analyses of periodicity in detection performance after a reset event suffer from extreme false-positive rates. Here we show that this conclusion is based on an incorrect implemention of a null-hypothesis of aperiodicity, and that a correct implementation confirms low false-positive rates. Furthermore, we clarify that the previously used method of shuffling-in-time, and thereby shuffling-in-phase, cleanly implements the null hypothesis of no temporal structure after the reset, and thereby of no phase locking to the reset. Moving from a corresponding phase-locking spectrum to an inference on the periodicity of the underlying process can be accomplished by parameterizing the spectrum. This can separate periodic from non-periodic components, and quantify the strength of periodicity.