bluuebunny/crossref_metadata_2025_split huggingface dataset:
MO129: Influence of Menstrual Situation on the Risk of Incident Microalbuminuria in School Workers: Miyagi Karoshi Prevention Study
Authors: Munakata Masanori , Hattori Tomomi , Konno Satoshi , Kubota-Nakayama Fumie , Inoue Nobutaka , Nakamura Tomohiro , Hozawa Atsushi 
Published: May 2022

Abstract

BACKGROUND AND AIMS
It has been recognized that menstrual situation impairs diagnostic accuracy of proteinuria. However, it is not fully understood how menstrual situation affects the degree of urinary albumin excretion, a well-known marker of endothelial damage. Moreover, there may be no report examining the dose–response relationship between contaminated blood and the risk of incident microalbuminuria.

METHOD
We studied 735 female school staffs (40.6 ± 11.2 years) who participated in the Miyagi Karoshi Prevention study. Urinary albumin excretion adjusted for creatinine (UAE) from morning spot urine sample was examined together with annual health check-up in 2019 and 2020. Menstrual situation was confirmed by a questionnaire at the time of examination. First of all, we examined the odds ratio for microalbuminuria of menstruation by means of logistic regression analysis using baseline data of 703 subjects with normo-albuminuria (NA) and 32 subjects with micro-albuminuria (MA). Next, we examined the dose–response relationship between urine blood category of − (n = 49), ± (n = 13 ), + (n = 22), 2+ (n = 13), 3+ (n = 47) and UAE or frequency of MA in 144 non-diabetic, non-hypertensive subjects without chronic kidney disease who were menstrual and non-menstrual situation in either year.

RESULTS
Age and BMI were similar between MA and NA groups, while frequency of menstruation (31.2 versus 15.4%, P &lt; .05), hypertension, or BP ≧ 140/90 mmHg or use of antihypertensive medications (34.4 versus 10.0%, P &lt; .001) and diabetes, or HbA1c ≧ 6.5% or use of antidiabetic medications (9.4 versus 2.3%, P &lt; .05) was higher in MA than in NA group. Multivariate logistic regression analysis has shown that MA was significantly associated with menstruation (OR 2.65: 95% CI 1.17–53.99) and hypertension (OR 4.41: 1.69–11.51). UAE was dose-dependently increased with an increase in urine blood category (P &lt; .001). Frequency of MA in each urine blood category was 0.0, 4.5, 0 and 17.0% (P = .001), respectively.

CONCLUSION
Contamination of blood into urine dose-dependently increases UAE in menstruated women. The diagnosis of MA may be possible even in menstrual situation if urine blood category is 2+ or lower.
MO132: Gait Speed in Predialysis Chronic Kidney Disease Patients: A Cross-Sectional Study from the Role of AST120 in Sarcopenia Prevention in Pre-Dialysis Chronic Kidney Disease Patients
Authors: Chul Kim Jun , Han Miyeun , Heon Song Sang , Kim Su-Hyun , Cha Ran-Hui , Hui Kang Seok , Suk An Won 
Published: May 2022

Abstract

BACKGROUND AND AIMS
Gait speed (GS) is an important measure of functional ability. The aim of this study was to investigate the factors associated with GS in patients with chronic kidney disease with respect to sarcopenic component, plasma uremic or inflammatory markers and quality of life.

METHOD
The RolE of AST120 in sarCOpenia preVEntion in pRe-dialYsis chronic kidney disease patients is a 48-week, randomized controlled, parallel group, open-label, multicentre trial to determine the role of AST-120 in patients with chronic kidney disease. A total of 150 study participants were recruited from six general hospitals in South Korea. The participants were classified into four groups according to GS: ≤0.8, 0.8–1.0, ≤1.0–1.3 and ≥1.3 m/s. Linear regression analysis was performed to identify the factors associated with GS.

RESULTS
The mean GS was 1.06 ± 0.3 m/s. The mean age of the total population was 65.0 ± 10.8 years, and 97 (64.7%) were males. The group with a GS ≤ 0.8 m/s was the oldest and had the highest proportion of participants with low education level and medical aid. The levels of albumin, creatinine, eGFR and proteinuria did not differ between the groups. Participants with a GS ≤ 0.8 m/s showed the lowest level of physical component scale (PCS) and mental component scale (MCS). The levels of IS, TNF-α and myostatin were not different between the groups; however, the level of IL-6 showed a higher trend in the lower GS group. HGS and GS showed weak correlations with one another (R2 = 0.066, P &lt; .001); however, GS and the SMI were not significantly associated (R2 = 0.016, P = .119).
In the multivariate linear regression analysis adjusted for age, sex, diabetes, and estimated glomerular filtration rate, medical aid (β = –18.4, P = .007), handgrip strength (β = 0.85, P = .031), interleukin-6 level (β = –13.2, P = .001), haemoglobin (β = 2.84, P = .041), MCS (β = 0.45, P &lt; .001) and PCS (β = 0.51, P &lt; .001) were significantly associated with GS. Specifically, physical functioning, role limitation due to physical health problems and bodily pain in PCS, role limitation due to emotional problems, vitality and social functioning in MCS were statistically significantly correlated with GS. In the kidney disease-specific scale, symptom/problem, work status, cognitive function, quality of social interactions, social support and overall health rating in kidney disease were statistically significantly correlated with GS in the multivariate analysis.

CONCLUSION
GS is associated with handgrip strength, interleukin-6 and various components of quality of life including MCS and PCS.
MO135: Efficacy and Safety of Bortezomib Combined with Autologous Stem Cell Transplantation in the Treatment of MGRS
Authors: Zhao Liang , Ren Guisheng , Guo Jinzhou , Xu Weiwei , Hong Liu Zhi , Huang Xianghua 
Published: May 2022

Abstract

BACKGROUND AND AIMS
To evaluate the efficacy and safety of bortezomib combined with autologous stem cell transplantation (ASCT) in the treatment of monoclonal gammopathy of renal significance (MGRS).

METHOD
The clinicopathologic data of 16 patients with non-AL MGRS who received bortezomib combined with ASCT in Jinling Hospital of Nanjing University School of Medicine from February 2012 to June 2021 were retrospectively analysed.

RESULTS
Twelve patients were male and four were female, with a median age of 49 years, a median serum creatinine was 1.71 mg/ dL (1.45, 2.09) and a median eGFR wad 42.1 mL/min/1.73 m2 (29.0, 51.6). Renal pathological types included seven patients were light chain deposition disease, two patients were heavy chain deposition disease, one patient was light and heavy chain deposition disease, five patients were light chain proximal tubulopathy and one patient was proliferative glomerulonephritis with monoclonal immunoglobulin deposition. Sixteen patients received bortezomib-based induction therapy with a median three courses before transplantation. Stem cells were successfully collected from all patients and CD34 + cell counts were 4.4–13.55 × 106/kg (8.77 ± 3.29 × 106/kg). All patients had successful haematopoietic reconstitution, and a median time of achieving granulocyte count of 500/L was 10 (9, 10) days, and a median time of achieving platelet count of 20 000/L was 12 (11, 13) days. The major treatment complications during transplantation were mucositis (87.5%), diarrhoea (62.5%), fever (56.3%), and nausea and vomiting (18.8%); the other rare complications were acute kidney injury, skin rashes and liver function damage. Haematologic responses were achieved in 15 patients (93.8%), with 10 patients (62.5%) achieved complete responses, 3 patients (18.8%) achieved very good partial responses, 2 patients (12.5%) achieved partial responses, and 1 patient had no haematologic responses. Before treatment with ASCT, seven patients (43.8%) achieved partial response, of which four achieved complete response after ASCT, and one patient did not achieve hematologic response but achieved complete response after ASCT. A total of 12 patients (75%) achieved renal response before ASCT and 14 patients (87.5%) achieved renal response after ASCT. The median follow-up time was 43.5 months. One patient died during the follow-up due to infection, and one patient developed end-stage renal disease during the follow-up. Three patients relapsed, with a median time of 49 months.

CONCLUSION
Our data demonstrated that ASCT is a safe and effective treatment for rigorously selected non-AL MGRS patients, with few serious treatment complications and high haematological and organ response rates.
MO140: Lower Serum 25-Hydroxyvitamin D Levels are Associated with Peripheral Arterial Stiffness in Patients with Non‑Dialysis Chronic Kidney Disease Stage 3–5
Authors: Liao Tsung-Yu , Boey Han-Bin , Lai Yu-Hsien , Wang Chih-Hsien , Hsu Bang-Gee 
Published: May 2022

Abstract

BACKGROUND AND AIMS
Vitamin D deficiency is associated with a higher mortality and incidence of cardiovascular disease. High brachial-ankle pulse wave velocity (baPWV) is independently associated with an increased risk of cardiovascular events, cardiovascular mortality and all-cause mortality in atherosclerotic cardiovascular disease patients. The aim of this study was to evaluate the relationship between serum 25-hydroxyvitamin D levels and baPWV in patients with CKD stage 3 to 5.

METHOD
Fasting blood samples and baseline characteristics were obtained from 180 CKD stage 3 to 5 patients. A commercial enzyme-linked immunosorbent assay was used to measure 25-hydroxyvitamin D levels. Automatic pulse wave analyzer (VaSera VS-1000) to measure baPWV values and both sides of baPWV value which is greater than 18.0 m/s was determined as peripheral arterial stiffness (PAS).

RESULTS
A total of 73 (40.6%) participants were assigned to the PAS group with baPWV of &gt;18 m/s in CKD patients. There were more patients with diabetes mellitus (P = .036), old age (P &lt; .001), higher systolic blood pressure (P &lt; .001), diastolic blood pressure (P = .015), high serum intact parathyroid hormone (iPTH) (P = .009), elevated C-reactive protein (P &lt; .001) and lower 25-hydroxyvitamin D (P &lt; .001) levels in the PAS group compared with the control group in CKD participants. A multivariate logistic regression analysis discloses that 25-hydroxyvitamin D [odds ratio (OR): 0.895, 95% confidence interval (CI): 0.828–0.968, P = .005] and old age (OR: 1.140, 95% CI: 1.088–1.194, P &lt; .001) were independently associated with PAS in in patients with CKD stage 3 to 5. Moreover, according to a multivariate forward stepwise linear regression analysis, OPN level is positively associated with cfPWV. By receiver operating characteristic (ROC) curve analysis, the area under the receiver operating characteristic curve of 25-hydroxyvitamin D level was 0.684 (95% CI: 0.611–0.751, P &lt; .001) for predicting PAS in patients with CKD stage 3 to 5.

CONCLUSION
Lower serum 25-hydroxyvitamin D levels and older age were associated with PAS measured by baPWV in patients with CKD stage 3 to 5.
MO142: Urinary Hemopexin As a Marker of Lupus Activity Among Egyptian SLE Patients with Proliferative Lupus Nephritis
Authors: Sabry Alaa , Mahmoud Rasha 
Published: May 2022

Abstract

BACKGROUND AND AIMS
To assess the role of urinary hemopexin in prediction of active lupus nephritis (LN) and correlate its level with disease activity and ability to predict response to induction therapy in Egyptian SLE patients with nephritis.

METHOD
A cohort case-control hybrid study included patients diagnosed as LN and were recruited during 1 year from the from nephrology department in Mansoura University Hospital (from year 2017 to 2018). Forty-four patients (2 males and 42 females) and 22 control subjects were included. They were divided into three groups. Group I : patients with active LN, group II : SLE patients without LN and group III: healthy control. All participants were subjected to full history taking, Laboratory investigations such as ANA, anti-dsDNA, serum C3, C4, 24-h urinary protein, serum and urinary creatinine and urinary haemopexin. Renal biopsies were done in those with LN if not contraindicated. Patients received induction therapy according to the KDIGO guidelines. Urinary haemopexin was repeated after 6 months of induction therapy in LN patients.

RESULTS
Urinary hemopexin was statistically higher in LN cases (11.85) IU/L compared to SLE without nephritis (4.84) IU/L and (3.63) IU/L in heathy subjects. There was a positive correlation between urinary haemopexin and proteinuria. Its level also significantly decreased after induction therapy.

CONCLUSION
Haemopexin level is higher in LN than SLE without nephritis and its level decreases after immune suppression. Its level correlates with disease activity However, it cannot replace the role of renal biopsy.
MO148: CT-Guided Native Kidney Biopsy by Interventional Nephrologists
Authors: Mohamed Amine Rahil , Michel Marc Jean , Deprele Carole , Bisaccia Vincent , Baudoin Ophelie , Delay Agnes , Legrand Eric 
Published: May 2022

Abstract

BACKGROUND AND AIMS
Histopathology of renal parenchyma is the key diagnostic in the treatment of kidney diseases by nephrologists. Most nephrologists perform renal biopsy using percutaneous ultrasound-guided technic. Generally, this act is very simple for the majority of patients, but when the kidney size is small or the patient has an extreme obesity, this act could be a real challenge with more risk of complications. In Annonay Hospital (North Ardeche, France) all percutaneous renal biopsies are performed by a CT guidance technic. We report a retrospective study of 123 patients who have had a CT-guided kidney biopsies by interventional nephrologists.

METHOD
Between January 2016 and June 2021, 123 CT-guided native kidney biopsies were performed by interventional nephrologists at Annonay Hospital in North Ardeche in France. A total of 77 men and 46 women were introduced in this retrospective study. The mean age was 64 years (1933–1990); the mean BMI was 26.54 (47–129 kg). In our facility, all renal biopsies were performed by CT guidance technique. The patient was installed in the prone position. Preliminary CT images at 5-mm axial slices covering the entire length of the kidney are obtained. A metallic mark is placed at the right side of the back to localize the entrance skin site, the lower pole cortex and to calculate the depth between the skin and the target. A local anesthetic agent is then injected following the calculating depth. A 16-gauge core biopsy is introduced following exactly the calculating depth and the position of the needle tip is confirmed on CT. Once two samples are acquired, the needle is removed and postprocedure images are obtained to assess for perinephric haemorrhage.

RESULTS
Renal parenchyma was obtained in all patients (100%); over 123 biopsies, 121 presented between 1 to 48 glomerulus (98.37%), 2 biopsies presented a medulla tissue (1.62%), 97 patients (78%) presented a perinephric haemorrhage no more than 1 cm in postprocedure images and 15 patients presented a macroscopic hematuria (12.19%). One patient required renal embolization for a rapid expansive perinephric haemorrhage with severe pain.

CONCLUSION
The CT-guided renal biopsy is a precise and rapid technique to have a renal parenchyma with a failure rate bordering 0%, but the cost and the radiations rate should be compared with the other methods.
MO153: Study of the Relationship between Atrial Fibrillation and The Functional State of the Kidneys in Patients with CHF
Authors: Karimdjanova Guzal 
Published: May 2022

Abstract

BACKGROUND AND AIMS
Chronic heart failure (CHF) is one of the most significant medical, economic and social problems of the 21st century. According to epidemiological studies, the prevalence of CHF in the USA and Western Europe ranges from 1.9% to 2.5% (Rosamond W. et al. 2007; Neumann T. et al. 2009), and this figure is steadily increasing.
The problem of cardiorenal relationships in patients with CHF occupies one of the leading places in clinical medicine in recent years. Research results indicate that even the earliest subclinical renal dysfunction is an independent risk factor for the development of cardiovascular complications (CVC) and death, as well as recurrent events in patients with CVD [1].
The aim of our study was to identify clinical, laboratory and instrumental differences between patients with CHF and permanent AF or persistent sinus rhythm (SR), as well as to study the relationship between AF and the functional state of the kidneys.

METHOD
80 patients (44 men, 36 women) with CHF aged 40 to 75 (mean age 62 ± 12 years) with CHF were examined. The exclusion criteria from the study were primary pathology of the kidneys, renal vessels and urinary tract, endocrine and oncological pathology. CHF was diagnosed and assessed according to the National Recommendations of the SHFS, RSC and RSMSP for the diagnosis and treatment of CHF (fourth revision), 2013

RESULTS
Among the examined patients, a persistent (&gt;1 year) form of AF occurred in 48.7% of patients. Sinus rhythm was observed in 51.3% of patients. Table 2 shows the characteristics of the main clinical manifestations in patients with CHF according to the presence/absence of AF. GFR was lower in patients with AF than without AF (57.6 ± 15.3 versus 68.2 ± 17.6 ml/min/1.73 m2 respectively, p &lt; 0.001) (Figure 1), in patients with CHF FC I, GFR was 84.3 ± 7.44 ml/min/1.73 m2, with CHF FC II 76.2 ± 16.34 ml/min/1.73 m2, with CHF FC III 62, 8 ± 7.3 ml/min/1.73 m2, with CHF FC IV 57.6 ± 5.1 ml/min/1.73 m2.

CONCLUSION
A feature of clinical symptoms in patients with chronic heart failure and atrial fibrillation, in contrast to patients with sinus rhythm, was a more pronounced edematous syndrome, and the echocardiographic picture was an increased size of the left atrium and right ventricle.
In patients with CHF who have CKD, mitral regurgitation is more often observed, the latter, as is known, due to volume overload, leads to remodeling of the left atrium.
MO156: The Choice of Empiric Antimicrobial Agent and its Association with Outcomes in Kidney Transplant Recipients with Urinary Sepsis
Authors: Królicki Tomasz , Bardowska Klaudia , Kudla Tobiasz , Królicka Anna , Letachowicz Krzysztof , Mazanowska Oktawia , Krajewski Wojciech , Poznański Paweł , Krajewska Magdalena , Kamińska Dorota 
Published: May 2022

Abstract

BACKGROUND AND AIMS
Efficient antibiotic therapy remains the cornerstone of successful sepsis treatment. Urinary sepsis, which remains the most common sepsis type in kidney transplant recipients (KTRs), is characterized by high prevalence of multidrug-resistant (MDR) bacterial strains, often limiting the choice of antimicrobial agents. The primary aim of this study was to elucidate the efficiency of primary empiric antimicrobial therapy in KTRs hospitalized for urosepsis, depending on the antibiotic choice.

METHOD
All primary urosepsis cases in KTRs hospitalized in 2014–2019 in the Transplantation Department of the Wroclaw Medical University Hospital were included retrospectively as the study group (n = 101). A total of 100 random KTRs hospitalized for primary urinary tract infection (UTI) were set as control group. The primary endpoint was the need for antibiotic change after 3 days of completed empiric treatment (due to lacking clinical response or proven antibiotic resistance). All patients were treated according to SSC guidelines with delay in antibiotic administration of no more than 1 h after the diagnosis of sepsis.

RESULTS
In the urosepsis and UTI groups, the need for antibiotic change after 3 days of treatment equaled 45.6% and 11%, respectively. Patients with urosepsis and inappropriate antibiotic therapy were at increased risk of death (OR = 10.1 with P = .021), need for acute renal replacement therapy (OR = 4.73 with P = .012) and non-recovery from AKI (OR = 3.18 with P = .031). Similar but not statistically significant trend was observed in the UTI group for lacking recovery from AKI (OR = 1.64 with P = .636). In both groups, the length of hospital stay was significantly longer in patients who did not receive appropriate empiric antimicrobial drug. Following antimicrobial agents were associated with appropriate successful treatment rates in the urosepsis and UTI groups: ciprofloxacine (0% versus 63%), amoxiciline with clavulonic acid (16.7% versus 89%), piperaciline with tazobactam (57% versus 60%), cefuroxime (67% versus 100%), third generation cephalosporines (76% versus 92%) and carbapenemes (100% versus 100%).

CONCLUSION
A delay in successful antibiotic therapy, caused by inappropriate choice of antimicrobial agents, for the treatment of urosepsis in KTRs is associated with detrimental kidney graft outcomes. Ciprofloxacine and amoxiciline with clavulonic acid should not be used for empiric therapy of urosepsis in this patient cohort. The development of urosepsis in KTRs as compared to non-septic UTI is associated with greater risk of antibiotic resistance among causative microorganisms and increased risk of antimicrobial failure.
MO157: Evaluating the Effect of SGLT2 Inhibitors on Proteinuria and Glomerular Filtration Rate in Non-Diabetic Patients with Proteinuria
Authors: Afrooghe Arya , Nematollahi Niloofar , Sadat Hakemi Monir , Nassiri Amirahmad 
Published: May 2022

Abstract

BACKGROUND AND AIMS
Proteinuria is strongly associated with the risk of CKD progression in non-diabetic and diabetic patients. SGLT2 inhibitors, as a promising new class, may provide protective effects for the kidney. Even though various studies have been conducted in this area, especially in diabetic patients, little information is available about how SGLT2 inhibitors affect proteinuria, kidney function or blood pressure in non-diabetic patients. Due to the lack of adequate information in previous studies, in this study, we investigated the effect of SGLT2 inhibitors on protein excretion and glomerular filtration rate (GFR) in patients with proteinuria.

METHOD
The present study was conducted as a single-group clinical trial (before and after). Thirty patients with proteinuria were enrolled. In addition to conventional treatment, empagliflozin 10 mg daily was administered. Height, weight, body mass index (BMI), GFR content, systolic and diastolic blood pressure, proteinuria and side effects in patients at the study's beginning and end were evaluated and recorded. In the end, the data were collected and analysed statistically.

RESULTS
In the present study, 30 patients with proteinuria were followed for 13.26 ± 5.90 weeks. The mean proteinuria of patients decreased significantly during the follow-up period (from an average of 1007.9 mg at the beginning of the study to 672.33 mg at the end (P &lt; .05)). There was no significant difference in serum creatinine levels and glomerular filtration levels (P &gt; .05). However, there was a significant decrease in blood pressure (systolic and diastolic) (P &lt; .05). BMI and patients' weight were decreased compared to the beginning of the study, but this difference was not statistically significant (P &gt; .05). Hypoglycaemia or hypokalemia did not occur in any of the patients. In 10% of patients, temporary dysuria was seen. Also, urinary tract infection was recorded in one patient (3.3%). In 3.3% of patients, the drug was discontinued due to intolerance.

CONCLUSION
The results of this study demonstrated that administration of empagliflozin significantly decreases proteinuria in non-diabetic patients with chronic kidney disease. However, further studies are recommended in this area.