bluuebunny/crossref_metadata_2025_split huggingface dataset:
Elaborate design of shell component for manipulating the sustained release behavior from core–shell nanofibres
Authors: Liu Yubo , Chen Xiaohong , Gao Yuhang , Yu Deng-Guang , Liu Ping 
Published: April 2022

Abstract
Background: The diversified combination of nanostructure and material has received considerable attention from researchers to exploit advanced functional materials. In drug delivery systems, the hydrophilicity and sustained–release drug properties are in opposition. Thus, difficulties remain in the simultaneous improve sustained–release drug properties and increase the hydrophilicity of materials.Methods: In this work, we proposed a modified triaxial electrospinning strategy to fabricate functional core–shell fibres, which could elaborate design of shell component for manipulating the sustained-release drug. Cellulose acetate (CA) was designed as the main polymeric matrix, whereas polyethylene glycol (PEG) was added as a hydrophilic material in the middle layer. Cur, as a model drug, was stored in the inner layer.Results: Scanning electron microscopy (SEM) results and transmission electron microscopy (TEM) demonstrated that the cylindrical F2–F4 fibres had a clear core–shell structure. The model drug Cur in fibres was verified in an amorphous form during the X-ray diffraction (XRD) patterns, and Fourier transformed infrared spectroscopy (FTIR) results indicated good compatibility with the CA matrix. The water contact angle test showed that functional F2–F4 fibres had a high hydrophilic property in 120 s and the control sample F1 needed over 0.5 h to obtain hydrophilic property. In the initial stage of moisture intrusion into fibres, the quickly dissolved PEG component guided the water molecules and rapidly eroded the internal structure of functional fibres. The good hydrophilicity of F2–F4 fibres brought relatively excellent swelling rate around 4600%. Blank outer layer of functional F2 fibres with 1% PEG created an exciting opportunity for providing a 96 h sustained-release drug profile, while F3 and F4 fibres with over 3% PEG provided a 12 h modified drug release profile to eliminate tailing–off effect.Conclusion: Here, the functional F2–F4 fibres had been successfully produced by using the advanced modified triaxial electrospinning nanotechnology with different polymer matrices. The simple strategy in this work has remarkable potential to manipulate hydrophilicity and sustained release of drug carriers, meantime it can also enrich the preparation approaches of functional nanomaterials.
A cancer-associated K-RAS mutant that preferentially binds GDP displays gain-of-function and atypical signaling
Authors: Qian Xiaolan , Pantsar Tatu ,   Alex G. Papageorge1, Tripathi Brajendra K. Brajendra K. , Sanchez-Solana Beatriz , Durkin Marian E. , Gao Yucheng , Esposito Dominic , Waybright Timothy , Stephen Andrew G. Stephen , Simanshu Dhirendra , Wang Dunrui , Lowy Douglas R. 
Published: April 2022

Abstract

Background: The RAS genes, which are the prototype for the RAS superfamily of small GTPases, encode guanine nucleotide binding proteins that are frequently mutated in cancer. The superfamily has five major branches: RAS, RHO, RAB, RAN, and ARF. Its wild type members function as molecular switches that are active when GTP-bound and inactive when GDP-bound. Previously analyzed cancer-associated point mutants of RAS, such as those affecting codons 12, 13, and 61, and mutants of other superfamily members have followed this paradigm, as their steady-state level of bound GTP is higher than that of the wild type protein. However, it is possible that a less common cancer-associated mutant might be active when bound to GDP. Methods: We searched the Catalog of Somatic Mutations in Cancer (COSMIC) database and the TCGA database in the NCI Genomic Data Commons cancer-associated mutations in the RAS superfamily beyond the commonly mutated RAS codons, conducted biological and biochemical tissue culture studies and in vitro biochemical guanine nucleotide binding studies of a K-RAS mutant identified by this search, and complemented these findings with all-atom molecular dynamics simulations. Results: The database search identified a recurrent cancer-associated K-RAS mutant, M67L, as well as another cancer-associated mutant that affect the same codon in K-RAS and N-RAS and additional point mutants in the analogous codon in 10 other members of the RAS superfamily of GTPases. Detailed analysis of the K-RAS M67L mutant indicated that it has a gain-of-function biologically, but its low GTP level is similar to that of wild type K-RAS. Unlike the GDP-bound wild type, the GDP-bound M67L mutant interacts with and activates at least three RAS effectors: RALGDS, PI3K-p110a, and RAPGEF6. However, it interacts weakly with the prototypic RAS effector, RAF. All-atom molecular dynamics simulations of the mutant, conducted with and without RALGDS, provide structural insight into these characteristics of the GDP-bound mutant. Conclusion: Cancer-associated mutations that are active when GDP-bound occur in K-RAS and probably in other members of the RAS superfamily.
Quasioptics for Increasing the Beam Efficiency of Wireless Power Transfer Systems
Authors: Pereira Ricardo , Carvalho Nuno 
Published: April 2022

Abstract
The highest beam efficiency in a wireless power transfer (WPT) system that uses focusing components was 51%. Achieved by William Brown in 1964, it used a ~3 m diameter reflector for a transfer distance of 7.62 m. This record was unbeaten for 58 years until now, as we present a system that surpasses Brown's work by 25%. Using the quasioptical framework for reducing spillover losses in WPT, we present a double-reflector system that achieved a higher beam efficiency than the state-of-the-art, when taking into account the system components. The transmitting and receiving antennas were 3D-printed conical smooth-walled horn antennas, specially designed for this system. The theoretical analysis enabled the design of a five-meter system, whose energy focus location has been experimentally verified. Following this successful measurement, the complete system was experimented upon, whose results are here described, enabling a high beam transfer efficiency of 63.75%, validating the theoretical results obtained previously. Additionally, the advantage of using quasioptics in radiative wireless power transfer applications is discussed, as well as the sensitivity of its systems by analyzing how the efficiency changes with variations of different parameters. Finally, a comparison of this system with the state-of-the-art is done by the proposal of new figures-of-merit, relating the systems' physical dimensions and beam efficiency. Through them, it becomes clear that our system outperforms the previous works in terms of the beam efficiency achieved when taking into account the system components used. Furthermore, this research is a paradigm shift by presenting a promising path for future WPT research through quasioptics, one that may lead to developments of such high efficiencies that will potentially enable commercial application of this technology in solving power supply issues in our society.
Association of cyclooxygenase-2 genetic polymorphism with gastric cancer in eastern Indian population
Authors: Uthansingh Kanishka , Mishra Debakanta , Pati Girish Kumar , Padhy Rabindra Nath , Sahu Manoj Kumar 
Published: April 2022

Abstract
The Gastric cancer (GC) is the problem seen more frequently in tropical countries. The expressivity of cyclooxygenase-2 (COX-2) and inherent individual susceptibility to oncogenicity are due to over-expression of and single nucleotide polymorphisms (SNPs). The present experimental case-control study aims to evaluate the role of over-expression of COX-2 polymorphisms in the development of gastric cancer (GC) in the region at Eastern India. The genomic DNA was isolated from the peripheral blood samples of 124 GC patients and 176 controls attending the hospital, during February 2017 to December 2020. GC with or without infection of halophile, Helicobacter pylori was diagnosed by the histo-pathological assessment. DNA was isolated of GC-cases and controls by the salting-out method. Three SNPs of COX-2 gene such as, -1195GA, -765GC, and − 1290AG were arbitrarily chosen to identify the genetic polymorphisms. Genotypes were analyzed by undertaking ‘polymerase chain reaction restriction fragment length polymorphism’ (PCR-RFLP). A total of 124 GC cases with 176 healthy individuals were enrolled in the study. A fraction of 10.5% cases had GG homozygous mutation alleles at -1195GA, while the 5% fraction had GG homozygous mutant alleles at -765GC, and an 8.9% fraction had GG homozygous mutant alleles at -1290AG, amongst all the GC cases. COX-2 polymorphisms were crucially associated with the risk of development of GC, compared to controls with p = 0.003, both in 1195 GA and 1290AG. COX-2 polymorphisms could play a crucial role in the development of GC in the coastal Eastern Indian region.
Machine learning–based triage to identify low-severity patients with a short discharge length of stay in emergency department
Authors: Chang Yu-Hsin , Shih Hong-Mo , Wu Jia-En , Huang Fen-Wei , Chen Wei-Kung , Cheng Dar-Min , Chung Yu-Ting , Wang Charles C.N. 
Published: April 2022

Abstract
Background: Overcrowding in emergency departments (ED) is a critical problem worldwide, and streaming can alleviate crowding to improve patient flows. Among triage scales, patients labeled as “triage level 3” or “urgent” generally comprise the majority, but there is no uniform criterion for classifying low-severity patients in this diverse population. Our aim is to establish a machine learning model for prediction of low-severity patients with short discharge length of stay (DLOS) in ED.Methods: This was a retrospective study in the ED of China Medical University Hospital (CMUH) and Asia University Hospital (AUH) in Taiwan. Adult patients (aged over 20 years) with Taiwan triage acuity scale level 3 were enrolled between 2018 and 2019. We used available information during triage to establish a machine learning model that can predict low-severity patients with short DLOS. To achieve this goal, we trained five models—CatBoost, XGBoost, decision tree, random forest, and logistic regression—by using large ED visit data and examined their performance in internal and external validation.Results: For internal validation in CMUH, 33,986 patients (75.9%) had a short DLOS (shorter than 4 h), and for external validation in AUH, there were 13269 (82.7%) patients with short DLOS. The best prediction model was CATBoost in internal validation, and area under the receiver operating cha racteristic curve (AUC) was 0.755 (95% confidence interval (CI): 0.743-0.767). Under the same threshold, XGBoost yielded the best performance, with an AUC value of 0.761 (95% CI: 0.742- 0.765) in external validation.Conclusions: This is the first study to establish a machine learning model by applying triage information alone for prediction of short DLOS in ED with both internal and external validation. In future work, the models could be developed as an assisting tool in real-time triage to identify low-severity patients as fast track candidates.
O Gestor escolar, sua influência na gestão democrática e participativa no magistério do Soyo
Authors: Lukombo Garcia 
Published: April 2022

Resumo:
O presente artigo tem como tema: o gestor escolar, sua influência na gestão democrática e participativa no Magistério do Soyo. Destacam-se os objectivos, o problema e a pergunta de pesquisa. Com o objectivo geral: Analisar o papel do gestor escolar, e sua influência na gestão democrática e participativa no Magistério do Soyo. Dessa maneira foi realizada uma revisão bibliográfica e documental, com o propósito de aprofundar os fundamentos e contributos teóricos sobre a temática em estudo, dando suportes científicos sobre o assunto que permitiu elaborar este artigo partindo de uma revisão conceitual e bibliográfica dos vários conteúdos, de uma perspectiva generalizada do tema até se atingir aos aspectos particulares. Seguiu-se posteriormente a elaboração e a aplicação dos instrumentos de colecta de dados, aos participantes com toda a informação necessária. Os mesmos foram elaborados com intuito de responderem aos objectivos propostos, baseados numa pesquisa de tipo não experimental, exploratória, a análise dos dados por meio de instrumentos de colecta de dados, tais como: levantamento bibliográfico, levantamento dos dados quantitativo-qualitativos, por via das entrevistas e questionários previamente elaborados, respeitando todos os critérios necessários das pesquisas fazendo referência aos aspectos considerados chave que nortearam a mesma. Finalmente, após a colecta dos dados, por via dos instrumentos de processamentos, foram demonstrados os resultados e que a maioria dos participantes afirmam que o gestor escolar tem muita influência no processo de gestão democrática e participativa na escola, fruto da dinâmica implementada que permite a participação da comunidade na gestão da escola. Palavras-chave: Gestão democrática. Gestão participativa. Gestor escolar
Assessment of Channel Migration of Koshi River in Nepal Using Remote Sensing and GIS
Authors: Chauhan Raju , Baniya Suchana , Deshar Rashila 
Published: April 2022

River channel shifting is the geomorphological process involving the
lateral movement of
an [alluvial](https://en.wikipedia.org/wiki/Alluvial) [river
channel](https://en.wikipedia.org/wiki/Channel_(geography)) across
its [floodplain](https://en.wikipedia.org/wiki/Floodplain). Koshi
river is characterized by high planform dynamics, especially in the
lower reaches. We studied the dynamics of channel planform and shifting
through systematic analysis and interpretation of diverse channel
configurations using multidate satellite images from 1999 to 2019 of the
Koshi River from Chatara to the Nepal-India border. Remote sensing
techniques and GIS environment was used for change analysis based on
imageries of 1999, 2009 and 2019. The channel shifting was determined by
assessing and calculating the transient changes in the planform from the
temporal satellite data. The result shows that over the stretch of 48
km, the Koshi River is highly braided with no distinct sub-channel
observed. Both the river stretch and braiding are greatest within
the southern portion compared to the northern part. Between 1999 and
2019, the area of the water channel is reduced by 24.08 km
whereas, the channel bars have increased by 68.08 km
. The river has experienced a clear shift of the
channel toward the west in recent years. The average annual rate of
shifting was estimated to be 21.6 m year towards
the west and 0.8 m year towards the east, with the
overall expansion of the river flood plains. Monitoring of river
planform helps in effective river management. This result can be
utilized for developing integrated river and land management plans in
the Koshi basin.
METAPHORS IN BRING ME THE HORIZONS SELECTED SONG LYRICS
Authors: Jati Laurentius Jalu Waskitho 
Published: April 2022

This research aims to analyze the selected Bring Me The Horizons song lyrics. There are two selected songs entitled Drown and Throne. The songs were chosen based on the variety of words used in the song lyrics. The aim of this research is to find out the types of metaphors found and the meanings of the selected songs. As a result, there are two research questions, namely: First, what types of metaphors are found in Bring Me The Horizon?s selected song lyrics? Second, what are the meanings of the songs? There are two sources that are used in this research. They are the primary subject and the secondary subject. The primary subject is two selected Bring Me The Horizons song lyrics. The secondary subjects are theories and information about metaphors, denotative and connotative meaning, formalist approach and biographical approach. The researcher used theories about metaphors and formalist approach in answering the first research question, while the theories about denotative and connotative meaning and biographical approach are used to answer the second research question. The researcher found three types of metaphors are used in Bring Me The Horizon?s selected song lyrics, namely: conventional metaphor, mixed metaphors and new metaphor. Conventional metaphor is the type of metaphor that mostly used in the selected song lyrics. After the types of metaphors are found, the researcher analyzes the meanings of the songs. Drown song tells about a person who is lonely, depressed and frustrated. Throne song tells about a person who wants to prove to others that he can do more than what people think.
WOMEN'S LANGUAGE FEATURES OF EILIS LACEY IN THE BROOKLYN MOVIE SCRIP
Authors: Pamikat Sekar Lantik 
Published: April 2022

This paper analyzed womens language features used by Eilis Lacey in the Brooklyn movie script. Brooklyn tells about Eilis Lacey, a pretty young woman who moved from Ireland to Brooklyn. Two research problems were formulated. First, what are the kinds of womens language features of Eilis Lacey in the Brooklyn movie script? Second, what are the uses of womens language features of Eilis Lacey in the Brooklyn movie script? In order to answer those two research questions, the researcher applied the theory of Lakoff (1975) on womens language. This research used a descriptive qualitative method that supported by quantitative method. The researcher described the data in sentences and tables and then counted the percentage shown in tables and diagrams. The researcher was the main instrument to collect the data needed. The data was taken from sentences used by Eilis Lacey in the Brooklyn movie script written by Nick Hornby. The researcher discovered that Eilis Lacey showed her femininity side in her using of womens language features related on Lakoffs theory when she was talking with her fiance, family, and friends. There were nine womens language features that she used, they were lexical hedges or fillers, tag questions, rising intonation on declaratives, intensifiers, super polite forms, emphatic stress, empty adjectives, precise color terms, and hypercorrect grammar.
ENGLISH EDUCATION MASTER STUDENTS’ PERCEPTIONS ON THEIR SELF-EFFICACY IN EFL SPEAKING LEARNING CONTEXTS
Authors: Wijaya Kristian Florensio 
Published: April 2022

AbstractSelf-efficacy should be fully integrated as one of the mainstays assisting multiverse EFL academicians to achieve greater speaking learning achievements, improve their actual communicative competencies, and justify their misconceptions of L2 speaking learning enterprises. Corresponding with these 3 aforementioned advantages, the full activation of robust self-efficacy will potentially allow EFL academicians to show greater effortful actions, resilience, motivation, and commitment to relentlessly forge their L2 communicative competencies in the presence of adverse speaking learning situations. This qualitative study was conducted in the support of the narrative inquiry approach to yield rejuvenated facts, trustworthy truth, and apparent evidence for worldwide EFL educationalists concerning the significance of self-efficacy implementations in diverse wide-ranging L2 speaking classroom vicinities. Two major positive influential factors are deemed as both internal and external factors affecting the luxuriant proliferation of striking L2 speaking skills as well as self-efficacy levels advancement namely the induction of long-life speaking learning endeavor and supportive speaking learning environments. For the future betterment of self-efficacy and EFL speaking studies, varied relevant research instruments need to be mutually accompanied by a considerable number of research participants to produce more significant research results contributing a richer understanding of affective second language learning fields. Keywords: Self-efficacy, EFL speaking, narrative inquiry
Does individualization of dialysis dose positively influence the quality of life of peritoneal dialysis patients while preserving adequate dialysis?
Authors: Fomegne Guy , Guillen Miguel-Ange , Ballout Assma , Bottiggi Andreas 
Published: April 2022

Our objective is to evaluate the impact of individualization of the dialysis dose on the quality of dialysis and the quality of life of our peritoneal dialysis patients.
Quality of life was assessed at least 3 months after individualization of the dialysis dose, by self-questionnaires using the SF-36 (short form) version of the KDQOL (Kidney Disease Quality Of Life) scale. The results of the KDQOL-SF36 are used as quantitative variables related to the achievement of a Kt/V>1.7. Dialysis dose was calculated from dialysate and 24-hour urine, blood samples from patients encoded in the French Language Peritoneal Dialysis Registry (RDPLF). https://www.rdplf-db.org. Pearson's significance test is used to look for a correlation between the SF-36 subscores of the KDQOL scale and Kt/V.
Fifteen patients (eight men, seven women) with a mean age of 65.93 years were eligible for the study.
Our results did not show a direct relationship between Kt/V and quality of life. There was an existing but weak correlation between the sub-scores "physical functioning" and Kt/V as well as between "role limitation due to physical problems" and Kt/V. These correlations do not appear to be significant according to Pearson's significance test. The individualization of the treatment does not seem to have a negative impact on the Kt/V and certain dimensions of the KDQOL SF36 score seem to be less altered (social interactions, social support, life in relation with others). Further studies taking into account the limitations of our study are necessary to generalize such a therapeutic approach.
Revue de presse club des jeunes néphrologues (CJN) :1er trimestre 2022 de la Dialyse à Domicile
Authors: Morinière Beaume Julie , Nodimar Céline , Seret Guillaume , Vrigneaud Laurence , Bataille Stanislas , Carceles Odette , Gosselin Morgane , Lanot Antoine , Lavainne Frederic 
Published: April 2022

Introduction (NDLR)
Un groupe de néphrologues issus du Club des jeunes Néphrologues sélectionne chaque trimestre à tour de rôle un article de la littérature internationale en rapport avec la dialyse à domicile, Dialyse Péritonéale ou Hémodialyse à Domicile, et en propose un résumé en français et son analyse. Ces résumés sont librement téléchargeables sur le site du RDPLF à l’adresse : https://www.rdplf.org/biblio.html. Depuis décembre 2018 ceux sélectionnés au cours du trimestre par ces néphrologues sont publiés sous leur nom dans la présente rubrique du Bulletin de la Dialyse à Domicile.
PENGARUH SENAM KAKI TERHADAP STATUS NEUROPATI PASIEN DIABETES MELITUS
Authors: Embuai Selpina 
Published: April 2022

<p>Diabetes mellitus adalah penyakit kronik yang dapat ditangani dengan mengendalikan dan mencegah terjadinya komplikasi. Desain penelitian adalah <em>quasy experiment</em> (<em>pre-post test with control design</em>). Penelitian ini terdiri dari 2 kelompok yaitu perlakukan dan kontrol dengan masing-masing responden sebanyak 40. Teknik sampling dengan <em>consecutive sampling</em>. Instrumen yang digunakan <em>monofilamen</em>t 10 g <em>neuropathy diabetic</em> test jenis <em>Semmes-Weinstein monofilament</em> dan Garpu tala 128 Hz. Analisis yang digunakan adalah <em>McNemar</em><em> </em>dan <em>Mann Whitney</em><em>.</em>Hasil penelitian menunjukan bahwa senam kaki terbukti berpengaruh terhadap perubahan status neuropati perifer dibuktikan dengan hasil penilaian neuropati perifer menggunakan monofilament dan garpu tala memiliki signifikansi kurang dari α (0.000 &lt; 0.05).<strong></strong></p>