bluuebunny/crossref_metadata_2025_split huggingface dataset:
Type 2 diabetes and hypertension in Vietnam: a systematic review and meta-analysis of studies between 2000 and 2020
Authors: Biswas Tuhin , Tran Nam , Thi My Hanh Hoang , Van Hien Pham , Thi Thu Cuc Nguyen , Hong Van Phan , Anh Tuan Khuong , Thi Mai Oanh Tran , Mamun Abdullah 
Published: August 2022

ObjectivesThe objective of this study was to determine the level of type 2 diabetes (T2DM) and hypertension (HTN) in Vietnam and to assess the trend and recommend the future direction of prevention research efforts.DesignWe searched scientific literature, databases including PubMed, EMBASE, CINHAL and Google Scholar; grey literature and reference lists for primary research published, nation database websites between 1 January 2000 and 30 September 2020. We adapted the modified Newcastle Ottawa Scale for assessing the quality of the study, as recommended by the Cochrane Collaboration.ResultsIn total, 83 studies met our inclusion criteria, representing data of approximately 239 034 population of more than 15 years of age in Vietnam. The findings show that prevalence rates varied widely across studies, from 1.0% to 29.0% for T2DM and 2.0% to 47.0% for HTN. For the total study period, pooled prevalence of T2DM and HTN in Vietnam for all studies was 6.0% (95% CI: 4.0% to 7.0%) and 25% (95% CI: 19% to 31%), respectively. Prevalence rate of both T2DM and HTN was higher among the male population compared with female counterpart.ConclusionThere is evidence of a rising trend of HTN and T2DM prevalence in Vietnam. Future research should focus on the major drivers, incidence and prognosis of T2DM and HTN. Policy approaches should base upon the trends of T2DM and HTN in Vietnam over the last 20 years and pay more attention on the effective interventions to combat T2DM and HTN. In our study, we included both English and Vietnamese language articles and seems that majority of the articles came from Vietnamese language.PROSPERO registration numberCRD42020182959.
Educational inequalities in adult mortality: a systematic review and meta-analysis of the Asia Pacific region
Authors: Beck Kathryn Christine , Balaj Mirza , Donadello Lorena , Mohammad Talal , Vonen Hanne Dahl , Degail Claire , Eikemo Kristoffer , Giouleka Anna , Gradeci Indrit , Westby Celine , Sripada Kam , Jensen Magnus Rom , Solhaug Solvor , Gakidou Emmanuela , Eikemo Terje Andreas 
Published: August 2022

ObjectivesIn this study, we aim to analyse the relationship between educational attainment and all-cause mortality of adults in the high-income Asia Pacific region.DesignThis study is a comprehensive systematic review and meta-analysis with no language restrictions on searches. Included articles were assessed for study quality and risk of bias using the Joanna Briggs Institute critical appraisal checklists. A random-effects meta-analysis was conducted to evaluate the overall effect of individual level educational attainment on all-cause mortality.SettingThe high-income Asia Pacific Region consisting of Japan, South Korea, Singapore and Brunei Darussalam.ParticipantsArticles reporting adult all-cause mortality by individual-level education were obtained through searches conducted from 25 November 2019 to 6 December 2019 of the following databases: PubMed, Web of Science, Scopus, EMBASE, Global Health (CAB), EconLit and Sociology Source Ultimate.Primary and secondary outcome measuresAdult all-cause mortality was the primary outcome of interest.ResultsLiterature searches resulted in 15 345 sources screened for inclusion. A total of 30 articles meeting inclusion criteria with data from the region were included for this review. Individual-level data from 7 studies covering 222 241 individuals were included in the meta-analyses. Results from the meta-analyses showed an overall risk ratio of 2.40 (95% CI 1.74 to 3.31) for primary education and an estimate of 1.29 (95% CI 1.08 to 1.54) for secondary education compared with tertiary education.ConclusionThe results indicate that lower educational attainment is associated with an increase in the risk of all-cause mortality for adults in the high-income Asia Pacific region. This study offers empirical support for the development of policies to reduce health disparities across the educational gradient and universal access to all levels of education.PROSPERO registration numberCRD42020183923.
Navigating the river(s) of systems change: a multi-methods, qualitative evaluation exploring the implementation of a systems approach to physical activity in Gloucestershire, England
Authors: Nobles James , Fox Charlotte , Inman-Ward Alan , Beasley Tom , Redwood Sabi , Jago Russ , Foster Charlie 
Published: August 2022

ObjectivesSystems approaches aim to change the environments in which people live, through cross-sectoral working, by harnessing the complexity of the problem. This paper sought to identify: (1) the strategies which support the implementation of We Can Move (WCM), (2) the barriers to implementation, (3) key contextual factors that influence implementation and (4) impacts associated with WCM.DesignA multi-methods evaluation of WCM was completed between April 2019 and April 2021. Ripple Effects Mapping (REM) and semi-structured interviewers were used. Framework and content analysis were systematically applied to the dataset.SettingWCM—a physical activity orientated systems approach being implemented in Gloucestershire, England.Participants31 stakeholder interviews and 25 stakeholders involved in 15 REM workshops.ResultsA white-water rafting analogy was developed to present the main findings. The successful implementation of WCM required a facilitative, well-connected and knowledgeable guide (ie, the lead organisation), a crew (ie, wider stakeholders) who’s vision and agenda aligned with WCM’s purpose, and a flexible delivery approach that could respond to ever-changing nature of the river (ie, local and national circumstances). The context surrounding WCM further strengthened and hampered its implementation. Barriers included evaluative difficulties, a difference in stakeholder and organisational perspectives, misaligned expectations and understandings of WCM, and COVID-19 implications (COVID-19 also presented as a facilitative factor). WCM was said to strengthen cohesion and collaboration between partners, benefit other agendas and policies (eg, mental health, town planning, inequality), and improve physical activity opportunities and environments.ConclusionsThis paper is one of the first to evaluate a systems approach to increasing physical activity. We highlight key strategies and contextual factors that influenced the implementation of WCM and demonstrate some of the wider benefits from such approaches. Further research and methodologies are required to build the evidence base surrounding systems approaches in Public Health.
Tangle number of virtual rational tangles
Authors: Khan Noureen A. 
Published: August 2022

We extend the classical coloring rule to compute the tangle (fraction) number of a virtual rational tangle. We use the contemporary argument used by Kauffman [Virtual knot theory, Eur. J. Comb. 20(7) (1999) 662–690] and show that tangle (fraction) number is a complete invariant. The main purpose of this paper is to provide an alternate yet elementary proof of John Conway’s classification theorem for the virtual rational tangles.
Transfer Learning for Low-Resource Multilingual Relation Classification
Authors: Nag Arijit , Samanta Bidisha , Mukherjee Animesh , Ganguly Niloy , Chakrabarti Soumen 
Published: August 2022

Relation classification (sometimes called
relation extraction
) requires trustworthy datasets for fine-tuning large language models, as well as for evaluation. Data collection is challenging for Indian languages, because they are syntactically and morphologically diverse, as well as different from resource-rich languages like English. Despite recent interest in deep generative models for Indian languages, relation classification is still not well served by public datasets. In response, we present
IndoRE
, a dataset with 21K entity- and relation-tagged gold sentences in three Indian languages (Bengali, Hindi, and Telugu), plus English. We start with a multilingual BERT (mBERT)-based system that captures entity span positions and type information, and provides competitive performance on monolingual relation classification. Using this baseline system, we explore transfer mechanisms between languages and the scope to reduce expensive data annotation while achieving reasonable relation extraction performance. Specifically, we

(a)
study the accuracy-efficiency trade-off between expensive, manually labeled gold instances vs. automatically translated and aligned silver instances to train a relation extractor,

(b)
device a simple mechanism for budgeted gold data annotation by intelligently converting distant-supervised silver training instances to gold training instances with human annotators using active learning, and finally

(c)
propose an ensemble model to provide a performance boost over that achieved via limited gold training instances.

We release the dataset for future research.

1
SIGCAS showcase
Authors: Goldweber Mikey , Kaczmarczyk Lisa , Clear Alison 
Published: August 2022

Over the years, SIGCAS has been involved in a number of conference activities. These include
• Workshops co-located with the SIGCSE Technical Symposium,
• In-Cooperation conferences; conferences organized by other organizations whose purpose/mission align with SIGCAS's mission, and
• Sponsored conferences; conferences put on by SIGCAS members and organized as official ACM/SIGCAS conferences: COMPASS, GoodIT, and previously, LIMITS.
Sex-Based Differences in Periprocedural Complications Following Lower Extremity Peripheral Vascular Intervention
Authors: Altin S. Elissa , Gitto Mauro , Secemsky Eric A. , Rao Sunil V. , Hess Connie N. 
Published: August 2022

Background:
Women with coronary artery disease are shown to have worse outcomes after percutaneous coronary intervention compared with men; however, less is known about sex-based outcomes following lower extremity peripheral vascular intervention (PVI) for symptomatic peripheral artery disease. The study aims to assess whether female sex is independently associated with periprocedural complications in patients undergoing PVI.

Methods:
Analysis includes patients undergoing lower extremity PVI from September 2016 to March 2020 from the Vascular Quality Initiative registry. Multivariate logistic regression was used to assess the independent association of female sex with post-PVI complications.

Results:

Of the 119 620 patients included, 47 316 (39.6%) were women. Analysis reflected that women were at higher risk of developing access site complications, including any hematoma (odds ratio [OR], 1.45 [1.35–1.57]), hematoma requiring transfusion (OR, 2.24 [1.82–2.76];
P
<0.001), hematoma requiring surgery (OR, 1.49 [1.19–1.86];
P
<0.001), pseudoaneurysm (OR, 1.69 [1.39–2.05];
P
<0.001), and access site occlusion (OR, 1.89 [1.15–3.08];
P
<0.001). Women also faced higher risks of target lesion dissection (OR, 1.36 [1.26–1.46];
P
<0.001), above-knee amputation (OR, 1.37 [1.18–1.58];
P
<0.001), and in-hospital mortality (OR, 1.21 [1.07–1.38];
P
=0.003).

Conclusions:
In a contemporary cohort, women undergoing lower extremity PVI for symptomatic peripheral artery disease were at higher risk than men of developing periprocedural complications, including moderate or severe access site bleeding, above-knee amputation, and in-hospital mortality. This increased risk persisted despite adjustment for differences in baseline patient or procedural characteristics and warrants further investigation.
Transcription Factor GATA4 Regulates Cell Type–Specific Splicing Through Direct Interaction With RNA in Human Induced Pluripotent Stem Cell–Derived Cardiac Progenitors
Authors: Zhu Lili , Choudhary Krishna , Gonzalez-Teran Barbara , Ang Yen-Sin , Thomas Reuben , Stone Nicole R. , Liu Lei , Zhou Ping , Zhu Chenchen , Ruan Hongmei , Huang Yu , Jin Shibo , Pelonero Angelo , Koback Frances , Padmanabhan Arun , Sadagopan Nandhini , Hsu Austin , Costa Mauro W. , Gifford Casey A. , van Bemmel Joke G. , Hüttenhain Ruth , Vedantham Vasanth , Conklin Bruce R. , Black Brian L. , Bruneau Benoit G. , Steinmetz Lars , Krogan Nevan J. , Pollard Katherine S. , Srivastava Deepak 
Published: August 2022

Background:
GATA4 (GATA-binding protein 4), a zinc finger–containing, DNA-binding transcription factor, is essential for normal cardiac development and homeostasis in mice and humans, and mutations in this gene have been reported in human heart defects. Defects in alternative splicing are associated with many heart diseases, yet relatively little is known about how cell type– or cell state–specific alternative splicing is achieved in the heart. Here, we show that GATA4 regulates cell type–specific splicing through direct interaction with RNA and the spliceosome in human induced pluripotent stem cell–derived cardiac progenitors.

Methods:
We leveraged a combination of unbiased approaches including affinity purification of GATA4 and mass spectrometry, enhanced cross-linking with immunoprecipitation, electrophoretic mobility shift assays, in vitro splicing assays, and unbiased transcriptomic analysis to uncover GATA4’s novel function as a splicing regulator in human induced pluripotent stem cell–derived cardiac progenitors.

Results:
We found that GATA4 interacts with many members of the spliceosome complex in human induced pluripotent stem cell–derived cardiac progenitors. Enhanced cross-linking with immunoprecipitation demonstrated that GATA4 also directly binds to a large number of mRNAs through defined RNA motifs in a sequence-specific manner. In vitro splicing assays indicated that GATA4 regulates alternative splicing through direct RNA binding, resulting in functionally distinct protein products. Correspondingly, knockdown of GATA4 in human induced pluripotent stem cell–derived cardiac progenitors resulted in differential alternative splicing of genes involved in cytoskeleton organization and calcium ion import, with functional consequences associated with the protein isoforms.

Conclusions:
This study shows that in addition to its well described transcriptional function, GATA4 interacts with members of the spliceosome complex and regulates cell type–specific alternative splicing via sequence-specific interactions with RNA. Several genes that have splicing regulated by GATA4 have functional consequences and many are associated with dilated cardiomyopathy, suggesting a novel role for GATA4 in achieving the necessary cardiac proteome in normal and stress-responsive conditions.
Optimal Channel Selection of Spaceborne Microwave Radiometer for Surface Pressure Retrieval over Oceans
Authors: Zhang Zijin , Dong Xiaolong , Zhu Di 
Published: August 2022

Abstract
The O2-band channel configuration of existing microwave radiometers is not optimal for surface pressure retrieval, which limits the surface pressure retrieval accuracy. In this study, we present the results of theoretically what might be the optimal microwave channels for surface pressure retrieval. An improved iterative selection method is used to select the channels that contain the highest cumulative content of surface pressure information. The selected optimal channel set comprises 16 channels, among which 10 channels are centered at the 50–60 GHz oxygen absorption band and 6 channels are centered around the 118.75 GHz oxygen absorption line. Two representative spaceborne microwave radiometers are used for comparisons, the Advanced Technology Microwave Sounder (ATMS) on board the Suomi National Polar-Orbiting Partnership (SNPP) satellite and the Microwave Humidity and Temperature Sounder (MWHTS) on board the Chinese Fengyun-3C (FY-3C) satellite. The results of information content analysis show that the optimal channel set contains more surface pressure information than that of the combination of SNPP/ATMS and FY-3C/MWHTS (SNPP/ATMS+FY-3C/MWHTS) channels. A representative dataset from the ERA5 data is input into the plane-parallel Microwave Radiative Transfer model to obtain the simulated brightness temperature observations of the selected optimal channels and the SNPP/ATMS+FY-3C/MWHTS channels. Using the simulated observations, retrieval experiments are performed. Experimental results show that retrieval accuracies of the optimal channel set are 1.09 and 1.64 hPa for clear-sky and cloudy conditions, respectively. The retrieval accuracies are 0.60 and 0.65 hPa better than that of the SNPP/ATMS+FY-3C/MWHTS channels for clear-sky and cloudy conditions, respectively.
Total tenderness score and pressure pain thresholds in persistent post-traumatic headache attributed to mild traumatic brain injury
Authors: Ashina Håkan , Al-Khazali Haidar Muhsen , Iljazi Afrim , Ashina Sait , Amin Faisal Mohammad , Schytz Henrik Winther 
Published: August 2022

Abstract
Objective
To investigate whether persistent post-traumatic headache attributed to mild traumatic brain injury (TBI) is associated with more pronounced pericranial tenderness and lower pressure pain thresholds (PPTs) in the head and neck region, compared with healthy controls.

Methods
Patients with persistent post-traumatic headache (n = 100) and age- and gender-matched healthy controls (n = 100) were included between July 2018 and June 2019. Total tenderness score (TTS) was used to assess pericranial tenderness by bilateral manual palpation in eight muscles or tendon insertions. Summation was then used to calculate a TTS from 0 to 48 based on individual right- and left-sided scores; higher TTS score indicated more pronounced pericranial tenderness. PPTs were examined in m. temporalis and m. trapezius (upper and middle part) using an electronic pressure algometer that applies increasing blunt pressure at a constant rate.

Results
The TTS score was higher in patients with persistent post-traumatic headache (median, 21; IQR, 12–31), compared with healthy controls (median, 10; IQR, 6–17; P < .001). PPTs were lower in patients with persistent post-traumatic headache than in controls in both the left-sided m. temporalis (mean ± SD, 157.5 ± 59.9 vs. 201.1 ± 65.2; P < .001) and right-sided m. temporalis (mean ± SD, 159.5 ± 63.8 vs. 212.3 ± 61.9; P < .001). Furthermore, patients with persistent post-traumatic headache also had lower left- and right-sided PPTs in the upper as well as middle part of m. trapezius, compared with healthy controls; all P values were .05 or less.

Conclusions
Among patients with persistent post-traumatic headache, pericranial tenderness was more pronounced and PPTs in the head and neck region were lower than in healthy controls free of headache and mild TBI. Further research is needed to better understand the involvement of pericranial myofascial nociceptors in the disease mechanisms underlying post-traumatic headache.
EGR2 is a hub-gene in myocardial infarction and aggravates inflammation and apoptosis in hypoxia-induced cardiomyocytes
Authors: Bo Zhixiang , Huang Shuwen , Li Li , Chen Lin , Chen Ping , Luo Xiaoyi , Shi Fang , Zhu Bing , Shen Lin 
Published: August 2022

Abstract
Background
Myocardial infarction (MI) is characterized by coronary artery occlusion, ischemia and hypoxia of myocardial cells, leading to irreversible myocardial damage. Therefore, it is urgent to explore the potential mechanism of myocardial injury during the MI process to develop effective therapies for myocardial cell rescue.

Methods
We downloaded the GSE71906 dataset from GEO DataSets, and the R software was used to identify the differentially expressed genes (DEGs) in mouse heart tissues of MI and sham controls. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment were performed to understand the significantly activated signaling pathways in MI. Protein–protein interaction (PPI) network was constructed to highlight the hub genes in DEGs. The Western Blot, qRT-PCR and TUNEL staining were used to explore the function of hub gene in hypoxia-induced cardiomyocytes in vitro.

Results
A total of 235 DEGs were identified in GSE71906 dataset. Functional enrichment analysis revealed that the upregulated genes were primarily associated with the inflammatory response and apoptosis. 20 hub genes were identified in PPI network, and the early growth response 2 (EGR2) was highlighted. In vitro. We confirmed the EGR2 was upregulated induced by hypoxia and revealed the upregulated EGR2 aggravates pro-inflammation and pro-apoptotic genes expression. In addition, EGR2 knockout mitigates hypoxia-induced inflammation and apoptosis in cardiomyocytes.

Conclusion
The present study identified the EGR2 was a hub gene in myocardial damage during MI process, the excessive EGR2 aggravates hypoxia-induced myocardial damage by accelerating inflammation and apoptosis in vitro. Therefore, targeting EGR2 offers a potential pharmacological strategy for myocardial cell rescue in MI.
Bidirectional association between visual impairment and frailty among community-dwelling older adults: a longitudinal study
Authors: Hou Tianxue , Liu Minhui , Zhang Jinghui 
Published: August 2022

AbstractBackgroundVision impairment is common among older adults, and it may be related to frailty. However, the longitudinal relationship between visual impairment and frailty is still unclear.MethodsWe used data from Round 1 to Round 5 from the National Health and Aging Trend Study. Two samples were community-dwelling older adults, sample 1 (without visual impairment) was classified according to whether they have pre-frailty/frailty at R1 (N = 3013) and sample 2 (without pre-frailty/frailty) was classified according to whether they have visual impairment at R1 (N = 1422), respectively. Frailty was measured using five criteria: experiencing exhaustion, unintentional weight loss, low physical activity, slow gait, and weak grip strength. Visual impairment was assessed by asking participants if they had any visual impairment. Generalized estimating equation models were used to examine the concurrent and lagged association between visual impairment and frailty.ResultsThe participants were on average 76 ± 7 years old, female (59%), non-Hispanic white (74%) with less than bachelor educated (73%), and 44% were pre-frail/frail in the older adults without visual impairment. Approximately 5% of participants had visual impairment at R1, and they tended to be female and non-Hispanic White in the older adults without frailty. The concurrent (OR, 95% CI = 1.55, 1.17-2.02) and lagged (OR, 95% CI = 1.79, 1.25-2.59) associations between frailty and visual impairment were significantly after controlling the covariates. Similarly, the concurrent (OR, 95% CI = 1.63, 1.32-2.04) and lagged (OR, 95% CI = 1.49, 1.20-1.87) associations between visual impairment and frailty were also significant.ConclusionsOverall, this study provides evidence for a longitudinal, bidirectional association between self-reported visual impairment and frailty. Future intervention programs to delay frailty progression should include strategies that may reduce the incidence of visual impairment.