A local human Vδ1 T cell population is associated with survival in nonsmall-cell lung cancer
Authors: Wu Yin , Biswas Dhruva , Usaite Ieva , Angelova Mihaela , Boeing Stefan , Karasaki Takahiro , Veeriah Selvaraju , Czyzewska-Khan Justyna , Morton Cienne , Joseph Magdalene , Hessey Sonya , Reading James , Georgiou Andrew , Al-Bakir Maise ,   TRACERx Consortium, Birkbak Nicolai J. , Price Gillian , Khalil Mohammed , Kerr Keith , Richardson Shirley , Cheyne Heather , Cruickshank Tracey , Wilson Gareth A. , Rosenthal Rachel , Aerts Hugo , Hewish Madeleine , Anand Girija , Khan Sajid , Lau Kelvin , Sheaff Michael , Schmid Peter , Lim Louise , Conibear John , Schwarz Roland , Kaufmann Tom L. , Huska Matthew , Shaw Jacqui , Riley Joan , Primrose Lindsay , Fennell Dean , Hackshaw Allan , Ngai Yenting , Sharp Abigail , Pressey Oliver , Smith Sean , Gower Nicole , Dhanda Harjot Kaur , Chan Kitty , Chakraborty Sonal , Litchfield Kevin , Thakkar Krupa , Tugwood Jonathan , Clipson Alexandra , Dive Caroline , Rothwell Dominic , Kerr Alastair , Kilgour Elaine , Morgan Fiona , Kornaszewska Malgorzata , Attanoos Richard , Davies Helen , Baker Katie , Carter Mathew , Lindsay Colin R. , Gomes Fabio , Blackhall Fiona , Priest Lynsey , Krebs Matthew G. , Chaturvedi Anshuman , Oliveira Pedro , Szallasi Zoltan , Royle Gary , Veiga Catarina , Skrzypski Marcin , Salgado Roberto , Diossy Miklos , Kirk Alan , Asif Mo , Butler John , Bilancia Rocco , Kostoulas Nikos , Thomas Mathew , MacKenzie Mairead , Wilcox Maggie , Nakas Apostolos , Rathinam Sridhar , Boyles Rebecca , Tufail Mohamad , Bajaj Amrita , Ang Keng , Chowdhry Mohammed Fiyaz , Shackcloth Michael , Asante-Siaw Julius , Leek Angela , Totten Nicola , Hodgkinson Jack Davies , Van Loo Peter , Monteiro William , Marshal Hilary , Blyth Kevin G. , Dick Craig , Fekete Charles , Lim Eric , De Sousa Paulo , Jordan Simon , Rice Alexandra , Raubenheimer Hilgardt , Bhayani Harshil , Hamilton Morag , Ambrose Lyn , Devaraj Anand , Chavan Hemangi , Begum Sofina , Buderi Silviu I. , Kaniu Daniel , Malima Mpho , Booth Sarah , Nicholson Andrew G. , Fernandes Nadia , Shah Pratibha , Proli Chiara , Gosney John , Danson Sarah , Bury Jonathan , Edwards John , Hill Jennifer , Matthews Sue , Kitsanta Yota , Rao Jagan , Tenconi Sara , Socci Laura , Suvarna Kim , Kibutu Faith , Fisher Patricia , Young Robin , Barker Joann , Taylor Fiona , Lloyd Kirsty , Lester Jason , Escudero Mickael , Stewart Aengus , Rowan Andrew , Goldman Jacki , Stone Richard Kevin , Denner Tamara , Nye Emma , Greco Maria , Nicod Jerome , Puttick Clare , Enfield Katey , Colliver Emma , Magness Alastair , Bailey Chris , Dijkstra Krijn , Barbè Vittorio , Vendramin Roberto , Kisistok Judit , Sokac Mateo , Demeulemeester Jonas , Cadieux Elizabeth Larose , Castignani Carla , Fu Hongchang , Grigoriadis Kristiana , Lee Claudia , Athanasopoulou Foteini , Hiley Crispin , Robinson Lily , Horey Tracey , Russell Peter , Papadatos-Pastos Dionysis , Lock Sara , Gilbert Kayleigh , Selvaraju Kayalvizhi , Ashford Paul , Pich Oriol , Watkins Thomas B. K. , Ward Sophia , Lim Emilia , Frankell Alexander M. , Abbosh Christopher , Hynds Robert E. , Sunderland Mariana Werner , Peggs Karl , Marafioti Teresa , Hartley John A. , Lowe Helen , Ensell Leah , Spanswick Victoria , Karamani Angeliki , Moore David , Beck Stephan , Chervova Olga , Tanic Miljana , Huebner Ariana , Dietzen Michelle , Black James R. M. , Ruiz Carlos Martinez , Bentham Robert , Naceur-Lombardelli Cristina , Zhai Haoran , Kanu Nnennaya , Gimeno-Valiente Francisco , Bola Supreet Kaur , Matos Ignacio Garcia , Shah Mansi , Cancino Felipe Galvez , Karagianni Despoina , Razaq Maryam , Akther Mita , Johnson Diana , Laycock Joanne , Hoxha Elena , Chain Benny , Pearce David R. , Chen Kezhong , Herrero Javier , Monk Fleur , Zaccaria Simone , Magno Neil , Prymas Paulina , Toncheva Antonia , Sivakumar Monica , Lucas Olivia , Hill Mark S. , Al-Sawaf Othman , Ung Seng Kuong , Gamble Sam , Wong Sophia , Lawrence David , Hayward Martin , Panagiotopoulos Nikolaos , George Robert , Patrini Davide , Falzon Mary , Borg Elaine , Khiroya Reena , Ahmed Asia , Taylor Magali , Choudhary Junaid , Janes Sam M. , Forster Martin , Ahmad Tanya , Lee Siow Ming , Navani Neal , Scarci Marco , Gorman Pat , Bertoja Elisa , Stephens Robert C. M. , Hoogenboom Emilie Martinoni , Holding James W. , Bandula Steve , Thakrar Ricky , Wilson James , Shah Mansi , Marcos  , Duran Vasquez , Litovchenko Maria , Vanloo Sharon , Pawlik Piotr , Thol Kerstin , Naidu Babu , Langman Gerald , Bancroft Hollie , Kadiri Salma , Middleton Gary , Djearaman Madava , Osman Aya , Shackleford Helen , Patel Akshay , Ottensmeier Christian , Chee Serena , Alzetani Aiman , Cave Judith , Scarlett Lydia , Richards Jennifer , Ingram Papawadee , Shaw Emily , Le Quesne John , Dawson Alan , Marrone Domenic , Dulloo Sean , Wilson Claire , Summers Yvonne , Califano Raffaele , Shah Rajesh , Krysiak Piotr , Rammohan Kendadai , Fontaine Eustace , Booton Richard , Evison Matthew , Moss Stuart , Novasio Juliette , Joseph Leena , Bishop Paul , Doran Helen , Granato Felice , Joshi Vijay , Smith Elaine , Montero Angeles , Crosbie Phil , McGranahan Nicholas , Jamal-Hanjani Mariam , Hackshaw Allan , Quezada Sergio A. , Hayday Adrian C. , Swanton Charles 
Published: May 2022

AbstractMurine tissues harbor signature γδ T cell compartments with profound yet differential impacts on carcinogenesis. Conversely, human tissue-resident γδ cells are less well defined. In the present study, we show that human lung tissues harbor a resident Vδ1 γδ T cell population. Moreover, we demonstrate that Vδ1 T cells with resident memory and effector memory phenotypes were enriched in lung tumors compared with nontumor lung tissues. Intratumoral Vδ1 T cells possessed stem-like features and were skewed toward cytolysis and helper T cell type 1 function, akin to intratumoral natural killer and CD8+ T cells considered beneficial to the patient. Indeed, ongoing remission post-surgery was significantly associated with the numbers of CD45RA−CD27− effector memory Vδ1 T cells in tumors and, most strikingly, with the numbers of CD103+ tissue-resident Vδ1 T cells in nonmalignant lung tissues. Our findings offer basic insights into human body surface immunology that collectively support integrating Vδ1 T cell biology into immunotherapeutic strategies for nonsmall cell lung cancer.