bluuebunny/crossref_metadata_2025_split huggingface dataset:
Anticoagulation for Left Ventricular Thrombi Secondary to COVID – Is Three Months Too Long?: A Case Report
Authors: Garg Rimmy , Sachdeva Amitoj , Fratti Juan Del Cid , Mortoti Samuel 
Published: March 2022

Abstract
Background: Venous and arterial thromboembolic events are common sequelae of COVID-19 infection. However, there are no set guidelines as to the appropriate duration of anticoagulation for such thrombotic events. Case Presentation: A 62-year-old woman presented with chest pain 2 weeks after she was diagnosed with COVID-19. She was found to have an anterior STEMI with a thrombotic occlusion of the left anterior descending artery as well as multiple left ventricular (LV) thrombi. The patient was treated with guideline directed medical therapy for acute coronary syndrome. As for the LV thrombi, she was bridged from heparin to warfarin with plan to continue anticoagulation for a minimum of 3 months; however, she was noted to have resolution of the thrombi in 2 months with no subsequent recurrence. Conclusion: In the setting of an acute myocardial infarction with apical akinesis, an LV thrombus is not uncommon. In such cases, ACC/AHA recommends oral anticoagulation (OAC) for 3 months while ESC recommends OAC for up to 6 months. There have been no large studies looking at the optimal duration for OAC for LV thrombi due to COVID-19. Given resolution of the thrombi in our patient within 2 months, we suggest a shorter length of anticoagulation for such cases guided by echocardiographic imaging. However, prospective data regarding this matter is first needed.
Experimental investigation of the low temperature oil-on-water cooling and lubrication in turning the hardened AISI D2 steel
Authors: Zhang Jihui , Tang Linhu , Ma Furong , Hu Yanjun , Li Baodong , Sun Yongji 
Published: March 2022

Abstract
In this paper, the influence of the cutting speed, feed, and the depth of cut on the cutting force, surface roughness, cutting temperature, and tool wear were experimentally investigated under the low temperature oil-on-water (LTOoW) cooling and lubrication condition in turning the hardened tool steel AISI D2 (60±1HRC) with the PCBN cutting tool. The results showed that the three-component cutting forces is FY>FZ>FX and the cutting speed has more significant effect on the ratio of FY/FZ at the range of 55-495 m/min cutting speed, 0.05-0.25 mm feed, and 0.05-0.25 mm depth of cut. The influence of the cutting speed on the cutting temperature is slightly more visible compared to the feed and depth of cut. In this experiment, a satisfactory surface roughness value of 0.54 µm can be obtained, gaining the effect of the turning instead of the grinding. The flank wear values of the PCBN tool are 142 µm and 148 µm respectively at the cutting speeds of 55 and 140 m/min; however, the flank wear value abruptly increases to 668 µm at a 495 m/min, which has a very serious impact on the tool life. The abrasive wear is considered to be a predominant wear mechanism on the flank wear of PCBN tool. The rake face is dominated by crater wear due to the high temperature, high pressure, high stress and high friction at the chip-tool interface.
Galvanic vestibular stimulation down-regulated NMDA receptors in vestibular nucleus of PD model
Authors: Kim Gyutae , Shin Nara , Kim Kyu-Sung 
Published: March 2022

Abstract
Parkinsonian symptoms relief by electrical stimulation is known to modulate neural network activity, and Galvanic vestibular stimulation (GVS) has been proposed as an alternative electrical stimulation. However, the underlying mechanism is still elusive. Due to the tight link from the peripheral area to vestibular nucleus (VN), the effect by GVS was investigated to understand the neural mechanism. Using SD rats, behavioral response, extracellular neural recording, and immunohistochemistry of VN were conducted before and after the construction of Parkinson’s disease (PD) model. Animals’ locomotion was tested using rota-rod, and single extracellular neuronal activity was recorded in VN. The immunohistochemistry detected AMPA and NMDA receptors in VN to assess the effects by different amounts of electrical charge (0.018, 0.09, and 0.18 coulombs) as well as normal and PD with no GVS. All PD models showed the debilitated function of locomotion, and the loss of TH+ neurons in mfb and striatum was observed. Sixty-five neuronal extracellular activities (32 canal & 33 otolith) were recorded, and no significant difference in the resting firing rates and the kinetic responding gain were found in the PD models. On the other hand, the numbers of AMPA and NMDA receptors increased in the PD model, and the effect by GVS was significantly evident in NMDA receptors (p < 0.018). Thus, the increased glutamate receptors in PD models were down-regulated by GVS, and the plastic modulation mainly occurred through NMDA receptor in VN.
In Silico Analysis of Pulmonary Arterial Hypertension to İdentify Key Biomarkers at Protein and RNA Levels
Authors: akçay sevinç 
Published: March 2022

Abstract
Background Pulmonary arterial hypertension (PAH) is a chronic cardiopulmonary disorder marked by a raised hypertension in the pulmonary arteries. There is no remedy for PAH, existing medications can help to reduce the disease’s progression. The goal of this research was to investigate potential protein and RNA biomarkers of PAH by bioinformatic analysis. Methods Two PAH datasets accessed from the publicly available Gene Expression Omnibus (GEO) database were utilized to discover differentially expressed genes (DEGs). Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses for common DEGs were conducted by the DAVID tool. Cytoscape was used to create the protein-protein interaction (PPI) and pick the top 10 hub genes. The transcription factors (TFs) and microRNAs (miRNAs) that target DEGs and hub genes were investigated using the JASPAR database. Potential therapeutics that target the top hub genes have been discovered. Results Ten hub genes were discovered to be linked to the pathogenesis of PAH (CCL5, TLR4, TLR1, SPP1, CYBB, HGF, IGF1, SELL, CD163 and POSTN). “Positive regulation of tumor necrosis factor biosynthetic process” and a “toll-like receptor signaling pathway” are the most enriched GO term and KEGG pathway, respectively. “hsa-mir-26b-5p, hsa-mir-146a-5p, hsa-mir-335-5p” and FOXC1, YY1, GATA2 are the top TFs targeting hub genes. 21 drugs targeting ten hub genes have been discovered. Conclusions Our results would help to discover the pathogenesis of PAH and hub genes, miRNAs and 10 TFs that might serve as potential therapeutic targets at protein and RNA levels for PAH patients.
Impact of the addition of antithymocyte globulin to post-transplant cyclophosphamide in haploidentical transplantation with peripheral blood compared to post-transplant cyclophosphamide alone in acute myeloid leukemia: a retrospective study on behalf of the Acute Leukemia Working Party of the EBMT
Authors: Battipaglia Giorgia , Labopin Myriam , Blaise Didier , Diez-Martin Jose Luis , Bazarbachi Ali , Vitek Antonin , Chevallier Patrice , Castagna Luca , Grillo Giovanni , Daguindau Etienne , López-Jiménez Javier , Koc Yener , Ruggeri Annalisa , Nagler Arnon , Mohty Mohamad 
Published: March 2022

Abstract
Background. Use of haploidentical cell transplantation (Haplo-HCT) with peripheral blood stem cells (PBSC) is increasing for acute myeloid leukemia (AML). We explored whether the addition of antithymocyte globulin (ATG) to post-transplant cyclophosphamide (PTCy) allows better outcomes than PTCy alone in Haplo-PBSC.Methods. We included 441 adult patients undergoing a first Haplo-PBSC for AML in first or second complete remission; graft-versus-host disease (GVHD) prophylaxis contained either PTCy alone (n = 374) or ATG + PTCy (n = 67), in addition to cyclosporine A (CsA) and mycophenolate mofetil (MMF) as other immunosuppressive agents. Transplant period was 2011–2019.Results. No major imbalances were observed between the two groups. Median age was 56 years and median year of Haplo-HCT was 2017 for both groups. Most patients received a reduced-intensity conditioning regimen (57% and 61% in PTCy and ATG + PTCy, respectively; p = 0.54). Median follow-up was 19 versus 15 months in PTCy and ATG + PTCy, respectively (p = 0.59). Neutrophil engraftment occurred in 97% and 98% of PTCy and ATG + PTCy, respectively. In univariate analysis, no statistical differences in transplant outcomes were observed between PTCy and ATG + PTCy. In multivariate analysis ATG + PTCy resulted in a lower risk of chronic GVHD as compared to PTCy alone (HR = 0.46, 95% CI 0.23–0.93; p = 0.03). No differences were observed for the other transplant outcomes.Conclusion. In Haplo-PBSC, addition of ATG to PTCy (with CsA and MMF) is feasible, better at preventing chronic GVHD, and survival and transplant outcomes are comparable to those with PTCy alone, without increasing transplant toxicity, mortality, or relapse incidence.
Fabrication of Biologically Active Fish Bone Derived Hydroxyapatite and Montmorillonite Blended Sodium Alginate Composite for In-vitro Drug Delivery studies
Authors: Ahamed A Fiaz , Manimohan Murugaiyan , Kalaivasan N 
Published: March 2022

Abstract
Fishbone comprising hydroxyapatite (bio-ceramic) is regularly viewed as a natural resource for biological and pharmaceutical applications. In this study, hydroxyapatite has been prepared from fishbone waste using thermal calcination method. The composite hydroxyapatite-montmorillonite-sodium alginate was synthesized by co-precipitation method. Various functional groups of biocomposite were characterised using Fourier Transform infrared spectroscopy (FT-IR). Thermal gravimetric analysis (TGA) and X-ray diffraction studies were exhibited the thermal stability and crystallinity of biocomposite respectively. The morphological surface of composites was studied using scanning electron microscopy (SEM). The synthesized composite was designed to study the enhanced biological potential such as antibacterial, antioxidant, antidiabetic, drug loading and the drug releasing ability. Antioxidant and anti-diabetic analysis of composite were studied using Phosphomolybdenum and α-Amylase inhibitory method respectively. The drug releasing ability of compounds (Doxorubicin and Curcumin) were investigated by UV–spectrophotometry method at different pH medium (pH = 5.5, 6.8 and 7.4). Additionally, In-vitro kinetic studies were carried out on composite to determine the drug releasing ability of doxorubicin and curcumin.
Spontaneous Peroneal Entrapment Neuropathy due to Anatomic Abnormality of Proximal Tibiofibular Joint：A Clinical Study of 10 Cases
Authors: Yusufu Aihemaitijiang , Chen Hui , Wumaierjiang Yiliyaer , Liu Zhenhui , Yushan Maimaiaili , Maimaiti Xiayimaierdan , Xu Lei 
Published: March 2022

Abstract
Background: Dislocation or instability of the proximal tibiofibular joint is often obscure, difficult to diagnose, easily overlooked by clinicians, and may be the cause of some unexplained cases of common peroneal nerve compression. Moreover, the literature on proximal tibiofibular joint dislocation is very limited, with only a few case reports. This study aimed to evaluate the morphological characteristics and anatomic variation of tibiofibular joint through preoperative auxiliary examination and intraoperative exploration and to discuss its clinical significance.Methods: From October 2015 to July 2021, a common peroneal nerve palsy diagnosis was made for 243 patients in our institution, of whom 10 were diagnosed with unexplained common peroneal nerve palsy. We carefully compared the results of intraoperative exploration with anteroposterior and lateral radiographs of the patients’ lower limbs and CT of their lower limbs to investigate the presence of bony structural abnormalities. Results: In the examination of lower limb CT, we found that the anatomical relationship of tibiofibular joint was significantly abnormal in three patients, among whom the preoperative CT plain scan of the lower limbs indicated that the fibula position of the affected limb was 2 cm lower than that of the opposite side in one typical patient. In one of the three patients with abnormal CT results, high common peroneal tension was found even after releasing the thickened fibers at the fibula head. The compression factor of this patient was the anatomic variation of the tibiofibular joint, which led to the common peroneal nerve being pulled downward by the fibular head; thus, peroneal osteotomy was performed during the operation. After osteotomy, the common peroneal nerve was markedly reduced in tone.Conclusions: Anatomic abnormalities or dislocation of the proximal tibiofibular joint may result in the entrapment of the common peroneal nerve. Preoperative CT examination of these patients is required to determine the presence of common peroneal nerve compression due to bony structural abnormalities. If the patient has a definite bony structural abnormality, peroneal osteotomy may be required at the time of peroneal nerve release.
Detecting Bots in Social-Networks Using Node and Structural Embeddings
Authors: Dehghan Ashkan , Siuta Kinga , Skorupka Agata , Dubey Akshat , Betlen Andrei , Miller David , Xu Wei , Kaminski Bogumil , Pralat Pawel 
Published: March 2022

Abstract
Users on social networks such as Twitter interact with and are influenced by each other without much knowledge of the identity behind each user. This anonymity has created a perfect environment for bot and hostile accounts to influence the network by mimicking real-user behaviour. To combat this, research into designing algorithms and datasets for identifying bot users has gained significant attention. In this work, we highlight various techniques for classifying bots, focusing on the use of node and structural embedding algorithms. We show that embeddings can be used as unsupervised techniques for building features with predictive power for identifying bots. By comparing features extracted from embeddings to other techniques such as NLP, user profile and node-features, we demonstrate that embeddings can be used as unique source of predictive information. Finally, we study the stability of features extracted using embeddings for tasks such as bot classification by artificially introducing noise in the network. Degradation of classification accuracy is comparable to models trained on carefully designed node features, hinting at the stability of embeddings.
Do Adriatic Bora winds impact Venice?
Authors: Qayyum Rizwan , Melito Lorenzo , Calantoni Joseph , Brocchini Maurizio , Sheremet Alex 
Published: March 2022

Abstract
The Jan. 2014 Adriatic Bora storm produced a measurable impact in north Adriatic, where tidal gauges recorded 5-cm sea-level fluctuations with a characteristic period of 100 min. Given the sensitivity of Venice flooding to sea-level perturbations and the localized, basin-transversal jet structure of the Bora winds, the observations are both significant and surprising. We investigate the event based on field observations off the Senigallia coast, Italy, and use simple linear analytical and numerical models. The model suggests that the oscillations observed are a mixture of edge-waves and seiches with a significant basin-transversal component, generated during the relaxation of Bora wind setup. The spatial structure of seiches explains the surprising basin-longitudinal reach of Bora storm. Despite the model simplicity, simulations results are consistent with sea-level measurements. The study suggests that Bora winds may have an impact on Venice and its surroundings and deserve more consistent monitoring and more accurate modeling.
The Influence of Body Fat Content and Distribution on Bone Mass in Healthy Chinese Adults
Authors: Chen Bin , Liu Gongwen , Wang Xiao , Gao Yan , Wang Aifei , Li Guangfei , Jia Peng , Dai Jun , Zhang Hui , Xu Youjia 
Published: March 2022

Abstract
Introduction: Many previous studies have reported a close relationship between body mass index (BMI) and bone mineral density (BMD). However, the effects of fat on bone health remain controversial, particularly for fat tissue distribution.Methods: This study enrolled 18,263 participants who had undergone health examinations. Body composition and BMD were measured using dual-energy X-ray absorptiometry. The relationships of BMI and regional fat percentage with BMD were detected by multiple linear regression and generalized additive models. The risk of low BMD was calculated using logistic regression.Results: There was a negative relationship between the regional fat percentage and FN BMD or LS BMD in both genders (P<0.05). In females, this relationship was bidirectional. Multiple logistic regression analyses showed that the risk for low BMD linearly increased across increasing regional fat percentage quartile categories. In females, the ORs for low LS BMD were 3.095 (95% CI, 2.618-3.658) for hip fat percentage and 1.532 (95% CI, 1.271-1.848) for waist fat percentage. In males, the ORs for low FN BMD were 2.211 (95% CI, 1.831-2.670) for waist fat percentage and 1.998 (95% CI, 1.694-2.355) for hip fat percentage.Conclusions: Overall, the body fat content was a negative predictor of the BMD, and this effect was gender- and location-dependent. In males, waist fat has a greater effect on the FN BMD, whereas in females, hip fat exerts a more negative influence on the LS BMD, which implies a cross-influence between regional fat content and bone mineral density in males and females.
Epigenetic Regulations, Motif and Pathway Identification of Myelofibrosis Chip Sequences
Authors: Sane Sravani , Bagchi Preenon , IA Shylesh Murthy 
Published: March 2022

Abstract
Next generation sequence technique that is Chromatin immunoprecipitation (ChIP) on the ChIP–Seq of Myelofibrosis. Myelofibrosis is a type of blood cancer which is also considered as a form of chronic leukemia. It is two types primary myelofibrosis and secondary myelofibrosis its leads to complication of an autoimmune disease, additional disease features include hepatosplenomegaly, extramedullary hematopoiesis (EMH) etc. In this work, its chip-Seq is retrieved from SRA database, the PCR duplicates are removed and finally the genome enriched region is identified using the MAC2 call peak tool. This annotated peak table was used to identify the motifs present in the chip-Seq of Myelofibrosis. Peak table was annotated to identify the genes and the corresponding pathways was identified from the KEGG pathway.
Fatigability And Quality Of Life In Type 2 Diabetes Mellitus Patients With And Without Diabetic Peripheral Neuropathy
Authors: Almurdi Muneera , Alrashoud Asma , Alhamdan Reema , Alammar Norah , Alshehri Ghaidaa , Rifaey Maha , Alsaleh Muneera , Kachanathu Shaji John , AlAbdulwahab Sami 
Published: March 2022

Abstract
Objectives: Physical fatigue and quality of life (QoL) characteristics in type 2 diabetes mellitus (T2DM) patients may or may not be influenced by long-term complications such as diabetic peripheral neuropathy (DPN). The purpose of the study was to investigate the association between muscle fatigability and QoL concerns in patients with T2DM with or without DPN.Methods: This study included sixty male and female subjects with an average age of 56±6.6 years from a diabetic screening clinic. Patients with type 2 diabetes mellitus with peripheral neuropathy (T2DMPN), patients with type 2 diabetes mellitus without peripheral neuropathy (T2DM), and healthy control subjects were randomly assigned to one of three groups (n=20). To assess fatigue, quality of life (QoL), and disability in all groups, the Fatigue Severity Scale (FSS), Short Form survey (SF-36), and Modified Neuropathy Disability Score (MNDS) were used.Results: FSS and QoL, particularly Physical Component Summary (PCS), were statistically significantly affected in T2DMPN patients as compared to T2DM patients and healthy controls (p<0.05). However, the Mental Component Summary (MCS) of QoL was found to be insignificant in all study groups, including healthy controls, T2DM, and T2DMPN (p>0.05). Both the healthy control and T2DM groups exhibited nearly identical levels of FSS and QoL, as well as PCS and MCS (p>0.05).Conclusions: T2DM with DPN has a significant impact on fatigability and QoL. This could be because of T2DM's pathological consequences and diabetic management in each demographic cohort. According to the findings, further efforts are needed to prevent or minimize deterioration in physical performance and QoL in T2DMPN patients.
Microencapsulation of Dragon Fruit Peel Extract by Freeze-Drying Using Hydrocolloids: Optimization by Hybrid Artificial Neural Network and Genetic Algorithm
Authors: Raj G. V.S. Bhagya , Dash Kshirod K. 
Published: March 2022

Abstract
The freeze drying encapsulation process was used to encapsulate dragon fruit peel extract with three distinct wall materials: maltodextrin, gum arabica, and gelatin. The process was modeled using a feed forward back propagation artificial neural network with four, eleven, and four neurons in the input, hidden, and output layers. Three of the four input neurons were concentrations of wall material (g), while the fourth was ultrasonication power. The four output neurons were encapsulation efficiency, antioxidant activity, hygroscopicity, and solubility of freeze-dried encapsulation powder. The procedure was optimized using hybrid artificial neural network (ANN) and genetic algorithm (GA) approach. The optimal wall material composition for encapsulation obtained by the integrated ANN and GA was 4.461 g maltodextrin, 3.863 g gum arabic, and 3.198 g gelatin. The optimal ultrasonication power for achieving a homogenous mixture was determined to be 123 W. At the optimal condition, the predicted values for the responses encapsulation efficiency, antioxidant activity, hygroscopicity, and solubility were found to be 88.143%, 81.702%, 6.924 g/100g, and 32.841%, respectively. Under optimal conditions, the relative deviation between the predicted model and experimental outcomes was less than 2.077%. The thermal stability of the encapsulated powder followed the first order kinetic modeling. The results showed that the sample treated at pH of 7 was more thermally stable at 80°C than the sample treated at pH of 3.6. The half-life time was found to be 140 min and 103 min for the sample treated at pH of 7 and 3.6, respectively.
New Template in Synthesis of Copper Tungsten -Mesoporous Silica for Photo Oxidative-Desulfurization of Dibenzothiophene
Authors: Salem Heba M. , Mohmed Dina , Zaki E. G. 
Published: March 2022

Abstract
A novel CuWO4/SiO2 heterojunction catalyst was successfully synthesized using a new sulfonamide derivative. The physical characteristics of the prepared samples were investigated by TGA, XRD, FTIR, SEM, UV, PL, and XPS. The prepared catalysts were applied as a nano photocatalyst for photooxidative desulfurization of dibenzothiophene under visible light using hydrogen peroxide as an oxidant. The photocatalytic oxidative desulfurization performances of the prepared samples were investigated. Various factors as the reaction time, dibenzothiophene concentration, catalyst dose, and the oxidizing agent dose were also studied. The prepared photocatalyst has high desulfurization activity in the removal of DBT under mild conditions. Results showed that the CuWO4/SiO2 exhibited considerably higher activity than neat support SiO2. Such improved photocatalytic activity is mainly attributed to the efficient separation of photogenerated electron-hole pairs on CuWO4/SiO2 heterojunction. Moreover, the synergistic effects of this photocatalytic oxidation and the green oxidant hydrogen peroxide played an essential role in desulfurization. The reaction is pseudo-first-order and can reach 98.6 % removal of dibenzothiophene after 70 min and 97.2% after four cycles.