bluuebunny/crossref_metadata_2025_split huggingface dataset:
A SINS/DVL/USBL integrated navigation and positioning IoT system with multiple sources fusion and federated Kalman filter
Authors: Luo Qinghua , Yan Xiaozhen , Wang Chenxu , Shao Yang , Zhou Zhiquan , Li Jianfeng , Hu Cong , Wang Chuntao , Ding Jinfeng 
Published: July 2022

AbstractThe navigation and positioning subsystem offers important position information for an autonomous underwater vehicle (AUV) system. It plays a crucial role during the underwater exploration and operations of AUV. Many scholars research underwater navigation and positioning. Various improved methods and systems were presented. However, as the diversity of the ocean environment, the random drift of the gyroscope, error accumulation, the variety of tasks, and other negative factors, the navigation and positioning results are uncertain and incredible. The accuracy, stability, and robustness are not guaranteed, which cannot meet the increasing application requirement. Therefore, we put forward a SINS/DVL/USBL integrated navigation and positioning IoT system with multiple resource fusion and a federated Kalman filter. In this method, we first present an improved SINS/DVL combined subsystem with a filtering gain compensation strategy. So we can enhance the accuracy and stability of the navigation and position system. Secondly, we proposed a USBL positioning subsystem with the Kalman filtering acoustic signals to improve USBL positioning performance. Lastly, we present a federated Kalman filter to fuse the positioning information from the SINS/DVL combined positioning subsystem and the USBL positioning subsystem. Through the three methods, we can enhance the positioning accuracy and robustness. Comprehensive simulation results indicated the feasibility and effectiveness of the proposed SINS/DVL/USBL integrated navigation and positioning system, which provides critical reference for other positioning method, and it also offers crucial position information for AUV to achieve high accuracy and efficiency tasks.
Mapping the viruses belonging to the order Bunyavirales in China
Authors: Teng Ai-Ying , Che Tian-Le , Zhang An-Ran , Zhang Yuan-Yuan , Xu Qiang , Wang Tao , Sun Yan-Qun , Jiang Bao-Gui , Lv Chen-Long , Chen Jin-Jin , Wang Li-Ping , Hay Simon I. , Liu Wei , Fang Li-Qun 
Published: July 2022

Abstract
Background
Viral pathogens belonging to the order Bunyavirales pose a continuous background threat to global health, but the fact remains that they are usually neglected and their distribution is still ambiguously known. We aim to map the geographical distribution of Bunyavirales viruses and assess the environmental suitability and transmission risk of major Bunyavirales viruses in China.

Methods
We assembled data on all Bunyavirales viruses detected in humans, animals and vectors from multiple sources, to update distribution maps of them across China. In addition, we predicted environmental suitability at the 10 km × 10 km pixel level by applying boosted regression tree models for two important Bunyavirales viruses, including Crimean-Congo hemorrhagic fever virus (CCHFV) and Rift Valley fever virus (RVFV). Based on model-projected risks and air travel volume, the imported risk of RVFV was also estimated from its endemic areas to the cities in China.

Results
Here we mapped all 89 species of Bunyavirales viruses in China from January 1951 to June 2021. Nineteen viruses were shown to infect humans, including ten species first reported as human infections. A total of 447,848 cases infected with Bunyavirales viruses were reported, and hantaviruses, Dabie bandavirus and Crimean-Congo hemorrhagic fever virus (CCHFV) had the severest disease burden. Model-predicted maps showed that Xinjiang and southwestern Yunnan had the highest environmental suitability for CCHFV occurrence, mainly related to Hyalomma asiaticum presence, while southern China had the highest environmental suitability for Rift Valley fever virus (RVFV) transmission all year round, mainly driven by livestock density, mean precipitation in the previous month. We further identified three cities including Guangzhou, Beijing and Shanghai, with the highest imported risk of RVFV potentially from Egypt, South Africa, Saudi Arabia and Kenya.

Conclusions
A variety of Bunyavirales viruses are widely distributed in China, and the two major neglected Bunyavirales viruses including CCHFV and RVFV, both have the potential for outbreaks in local areas of China. Our study can help to promote the understanding of risk distribution and disease burden of Bunyavirales viruses in China, and the risk maps of CCHFV and RVFV occurrence are crucial to the targeted surveillance and control, especially in seasons and locations at high risk.

Graphical abstract
Combating the global spread of poverty-related Monkeypox outbreaks and beyond
Authors: Tambo Ernest , Al-Nazawi Ashwaq M. 
Published: July 2022

AbstractThe current unprecedented Monkeypox outbreaks emergence and spread on non-endemic countries has led to over 3413 laboratory confirmed cases and one death, and yet, does not constitute a public health emergency of international concern as June 23th 2022. We urgently call for collective regional and global partnership, leadership commitment and investment to rapidly strengthen and implement Monkeypox World Health Organization outbreak Preparedness and emergency response actions plans implementation against Monkeypox outbreak. Given the importance of human–animal–environment interface and transmission dynamics, fostering global and regional One Health approach partnership and multisectoral collaboration programs have timely and robust sustained investment benefits on poverty-linked Monkeypox and other emerging epidemics population-based programs, while leveraging from lessons learnt. Moving forward requires addressing priority research questions listed and closing the knowledge gaps for Monkeypox and others neglected tropical diseases roadmap implementation in vulnerable and at risk countries.
Attitudes towards disordered eating in the rock climbing community: a digital ethnography
Authors: Strand Mattias 
Published: July 2022

Abstract
Background
Rock climbing is an antigravitational sport in which a low body weight may intuitively seem beneficial. A small number of studies have found an increased prevalence of disordered eating among adolescent and adult climbers. However, to date there has been no qualitative research into the attitudes towards disordered eating and body image in the rock climbing community.

Methods
This explorative study employed a netnographic approach with the aim of understanding how topics related to food, dieting, and disordered eating in the climbing community are addressed in online conversations. Discussion forums on nine major climbing websites as well as three climbing-related forums on the online community Reddit were searched for posts and comments related to the research question. The collected data were then assessed through thematic analysis, generating a number of themes and subthemes.

Results
Five overarching themes, labelled “Is there a problem?”, “Subjective experiences”, “Why and how is weight an issue?”, “The importance of context”, and “What can be done?”, were identified among the forum posts. Most forum users acknowledge that eating disorders are indeed a problem relevant to the climbing community, although a significant minority disagrees. While the assumed benefits of a low weight are clearly a dominant idea among climbers, weight may have become less important over time. Forum users also attest to ways in which climbing may in fact be helpful in fostering a positive body image, such as highlighting performance over aesthetics or emphasizing wholesome community values.

Conclusions
This study demonstrates that the topic of disordered eating and negative body image is far from a blind spot or a “dark secret” within the rock climbing community, as is sometimes claimed. An undue focus on low body weight among climbers must be balanced by proper nutritional advice and healthy role models, not least for young climbers who may feel pressured to lose weight as a quick but short-sighted way to boost performance. Clinicians should be aware of the prevailing ‘weight talk’ in the climbing community and be attentive to negative body image and disordered eating in their patients.
Bioequivalence evaluation and food effect assessment of Lisinopril/amlodipine tablets in healthy Chinese subjects under fasting and fed conditions
Authors: Li Ting , Liu Yan-ping , Liu Shu-qin , Shi Ping , Jiang Xin , Tao Ye , Gao Xiao-meng , Ma Ya-ping , Cao Yu 
Published: July 2022

AbstractPurposeThe combination of lisinopril and amlodipine has a marked additional effect on blood pressure and fewer side effects than individual monotherapy. This study was conducted to compare the pharmacokinetic parameters and evaluate the bioequivalence between two Lisinopril/amlodipine tablets in healthy Chinese subjects.MethodsA single center, randomized, open-label, single-dose, two-period crossover bioequivalence study was designed in healthy Chinese subjects under both fasting and fed conditions. Blood samples were collected before drug administration and at 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 24, 36, 48, 72, 96, 144, 168 h after administration. Liquid chromatography-tandem mass spectrometry (LC–MS/MS) was applied to determine the plasma concentration of lisinopril and amlodipine. Maximum concentration (Cmax) and area under the concentration–time curve (AUC) were used to evaluate bioequivalence. Adverse events were recorded.ResultsNinety-two healthy subjects were enrolled, and 75 completed the study. The 90% confidence intervals (CIs) of the ratio of geometric means (GMRs) of Cmax, AUC0-t,and AUC0-∞of lisinopril and amlodipine under both fasting and fed conditions fell within the conventional bioequivalence criteria of 0.80–1.25. A high-fat meal appeared to decrease the Cmaxand AUC of lisinopril. No severe adverse events were observed.ConclusionThe trial demonstrated that the test and the reference lisinopril/amlodipine tablets were bioequivalent and well tolerated in Chinese people under fasting and fed conditions.Trial registrationClinical Trails.gov identifier,NCT04885660(retrospectively registered in 13/05/ 2021).
Implementation of Long Short-Term Memory and Gated Recurrent Units on grouped time-series data to predict stock prices accurately
Authors: Lawi Armin , Mesra Hendra , Amir Supri 
Published: July 2022

AbstractStocks are an attractive investment option because they can generate large profits compared to other businesses. The movement of stock price patterns in the capital market is very dynamic. Therefore, accurate data modeling is needed to forecast stock prices with a low error rate. Forecasting models using Deep Learning are believed to be able to predict stock price movements accurately with time-series data input, especially the Long Short-Term Memory (LSTM) and Gated Recurrent Unit (GRU) algorithms. Unfortunately, several previous studies and investigations of LSTM/GRU implementation have not yielded convincing performance results. This paper proposes eight new architectural models for stock price forecasting by identifying joint movement patterns in the stock market. The technique is to combine the LSTM and GRU models with four neural network block architectures. Then, the proposed architectural model is evaluated using three accuracy measures obtained from the loss function Mean Absolute Percentage Error (MAPE), Root Mean Squared Percentage Error (RMSPE), and Rooted Mean Dimensional Percentage Error (RMDPE). The three accuracies, MAPE, RMSPE, and RMDPE, represent lower accuracy, true accuracy, and higher accuracy in using the model.
Intracellular accumulation of tau inhibits autophagosome formation by activating TIA1-amino acid-mTORC1 signaling
Authors: Li Meng-Zhu , Liu En-Jie , Zhou Qiu-Zhi , Li Shi-Hong , Liu Shi-Jie , Yu Hai-Tao , Pan Qi-Hang , Sun Fei , He Ting , Wang Wei-Jin , Ke Dan , Feng Yu-Qi , Li Jun , Wang Jian-Zhi 
Published: July 2022

Abstract
Background
Autophagy dysfunction plays a crucial role in tau accumulation and neurodegeneration in Alzheimer’s disease (AD). This study aimed to investigate whether and how the accumulating tau may in turn affect autophagy.

Methods
The primary hippocampal neurons, N2a and HEK293T cells with tau overexpression were respectively starved and treated with vinblastine to study the effects of tau on the initiating steps of autophagy, which was analysed by Student's two-tailed t-test. The rapamycin and concanamycin A were employed to inhibit the mammalian target of rapamycin kinase complex 1 (mTORC1) activity and the vacuolar H+-ATPase (v-ATPase) activity, respectively, which were analysed by One‐way ANOVA with post hoc tests. The Western blotting, co-immunoprecipitation and immunofluorescence staining were conducted to gain insight into the mechanisms underlying the tau effects of mTORC1 signaling alterations, as analysed by Student's two-tailed t-test or One‐way ANOVA with post hoc tests. The autophagosome formation was detected by immunofluorescence staining and transmission electron microscopy. The amino acids (AA) levels were detected by high performance liquid chromatography (HPLC).

Results
We observed that overexpressing human full-length wild-type tau to mimic AD-like tau accumulation induced autophagy deficits. Further studies revealed that the increased tau could bind to the prion-related domain of T cell intracellular antigen 1 (PRD-TIA1) and this association significantly increased the intercellular level of amino acids (Leucine, P = 0.0038; Glutamic acid, P = 0.0348; Alanine, P = 0.0037; Glycine, P = 0.0104), with concordant upregulation of mTORC1 activity [phosphorylated eukaryotic translation initiation factor 4E-binding protein 1 (p-4EBP1), P < 0.0001; phosphorylated 70 kDa ribosomal protein S6 kinase 1 (p-p70S6K1), P = 0.0001, phosphorylated unc-51-like autophagy-activating kinase 1 (p-ULK1), P = 0.0015] and inhibition of autophagosome formation [microtubule-associated protein light chain 3 II (LC3 II), P = 0.0073; LC3 puncta, P < 0.0001]. As expected, this tau-induced deficit of autophagosome formation in turn aggravated tau accumulation. Importantly, we also found that blocking TIA1 and tau interaction by overexpressing PRD-TIA1, downregulating the endogenous TIA1 expression by shRNA, or downregulating tau protein level by a small proteolysis targeting chimera (PROTAC) could remarkably attenuate tau-induced autophagy impairment.

Conclusions
Our findings reveal that AD-like tau accumulation inhibits autophagosome formation and induces autophagy deficits by activating the TIA1/amino acid/mTORC1 pathway, and thus this work reveals new insight into tau-associated neurodegeneration and provides evidence supporting the use of new therapeutic targets for AD treatment and that of related tauopathies.
A feasibility study on yoga’s mechanism of action for chronic low back pain: psychological and neurophysiological changes, including global gene expression and DNA methylation, following a yoga intervention for chronic low back pain
Authors: Adhikari Bandita , Starkweather Angela , Xu Wanli , Acabchuk Rebecca L. , Ramesh Divya , Eze Bright , Yang Yuxuan , Yang Gee Su , Walker Joseph , Laubenbacher Reinhard , Park Crystal L. 
Published: July 2022

Abstract
Introduction

Yoga has been shown to reduce pain and improve function in populations with chronic low back pain (cLBP), yet the underlying molecular mechanisms remain elusive. This study examined the feasibility and acceptability of a yoga research protocol, including recruitment, retention, and data collection, and investigated the preliminary effects of yoga on psychological and neurophysiological functions, including gene expression and DNA methylation profiles, in participants with cLBP.

Methods
A one-arm trial was conducted with 11 participants with cLBP who enrolled in a 12-week yoga intervention. Data on subjective pain characteristics, quantitative sensory testing, and blood for analysis of differentially expressed genes and CpG methylation was collected prior to the start of the intervention and at study completion.

Results
Based on pre-determined feasibility and acceptability criteria, the yoga intervention was found to be feasible and highly acceptable to participants. There was a reduction in pain severity, interference, and mechanical pain sensitivity post-yoga and an increase in emotion regulation and self-efficacy. No adverse reactions were reported. Differential expression analysis demonstrated that the yoga intervention induced increased expression of antisense genes, some of which serve as antisense to known pain genes. In addition, there were 33 differentially hypomethylated positions after yoga (log2 fold change ≥ 1), with enrichment of genes involved in NIK/NF-kB signaling, a major pathway that modulates immune function and inflammation.

Discussion/conclusions
The study supports the feasibility and acceptability of the proposed protocol to test a specific mechanism of action for yoga in individuals with cLBP. These results also support the notion that yoga may operate through our identified psychological and neurophysiologic pathways to influence reduced pain severity and interference.
Anxiety and prior victimization predict online gender-based violence perpetration among Indonesian young adults during COVID-19 pandemic: cross-sectional study
Authors: Wirawan Gede Benny Setia , Hanipraja Magdalena Anastasia , Chrysanta Gabrielle , Imtaza Nadya , Ahmad Karima Taushia , Marlina Inda , Mahendra Dimas , Larosa Alvin Theodorus 
Published: July 2022

Abstract
Background
Most of human interactions moved to the cyberspace for much of the pandemic. It was no surprise that online violence was also on the rise. One of the objectives of this study was to describe the prevalence and risk factors of online gender-based violence (OGBV) perpetration during the COVID-19 pandemic.

Results
The final analysis included 1006 respondents, 84.2% of whom were women and 94.5% were heterosexual. Over 60% of respondents admitted having perpetrated at least one type of OGBV once. It included 58.6% of women who admitted having perpetrated OGBV. Logistic regression analysis identified anxiety, online disinhibition, and history of victimization as independent risk factors of perpetration with an adjusted odds ratio (aOR) of 1.82 (95% CI 1.30–2.56), 1.38 (95% CI 1.03–1.85), and 9.72 (95% CI 5.11–18.51), respectively. Sub-group analysis that identified these factors also facilitated increased frequency and severity of OGBV perpetration.

Conclusions
We found a high proportion of OGBV perpetration among young adults during the pandemic among all genders although women were grossly overrepresented among the respondents. Risk factors of perpetration included anxiety, online disinhibition, and prior victimization. The pandemic situation which heightened general anxiety and increased dependency on online communication may facilitate the perpetration of OGBV. The generalization of this result should pay attention to the caveat that the demographic of respondents is heavily skewed toward women.
Effect of physicochemical parameters on Anopheles mosquitoes larval composition in Akure North Local Government area of Ondo State, Nigeria
Authors: Akeju Adebayo Victor , Olusi Titus Adeniyi , Simon-Oke Iyabo Adepeju 
Published: July 2022

AbstractBackgroundA lot of factors contribute to the breeding ofAnophelesmosquitoes, especially vectors of malaria parasites. This indirectly contributes to the transmission of these parasites. The physicochemical parameters associated with the population ofAnopheleslarvae were studied for the period of twelve months in five selected communities in Akure North Local Government area of Ondo State. This study was carried out to understand the relationship between selected physicochemical parameters and the population ofAnopheleslarvae in the study area.ResultsElectrical conductivity was significantly correlated with the abundance ofAn. gambiaeandAn. funestusin the area (r = 0.840 and 0.843, respectively). Abundance ofAnopheleslarvae follows a positive linear regression with electrical conductivity (R2 = 0.691). The pH was not significantly different in all the communities (P > 0.05); pH was negatively correlated with the abundance ofAn. gambiaeandAn. funestuslarvae,r =  − 0.530 and − 0.470, respectively.Anopheleslarvae population decreases as pH increases (R2 = 0.292). Total dissolved solid was positively correlated with the abundance ofAnopheleslarvae, though the correlation was weak (r = 0.21). There was slightly increase inAnopheleslarvae population as total dissolved solid increases (R2 = 0.048). The abundance ofAnopheleslarvae increases as the dissolved oxygen,R2 = 0.552. Dissolved oxygen was not significantly correlated withAnopheleslarvae population (r =  − 0.734 and − 0.789 , respectively), there was no significant difference across the study area (P > 0.05). Temperature was significantly correlated with the abundance ofAnopheleslarvae (r = 0.74).Anopheleslarvae increase as the temperature increases (R2 = 0.582).ConclusionsThe study revealed the important physicochemical parameters that influence the abundance ofAnopheleslarvae in the study area. Manipulation of these important parameters could help in reducing the population of the immature stages of this vector.
Successful reversal of a rare case of amitraz poisoning with yohimbine—a case report
Authors: Gupta Ankur , Narang Achint , Shandilya Nikhil , Sharma Aman , Kathuria Rahul , Gupta Aakriti 
Published: July 2022

Abstract
Background
Amitraz is an insecticidal agent and its poisoning cases are rare. We report the successful treatment of amitraz poisoning using yohimbine as an antidote. There is only a single other case report in literature of usage of yohimbine as antidote to amitraz poisoning in a 3-year-old child.

Case presentation
A 27-year-old woman presented to the hospital with features of severe amitraz intoxication-respiratory depression and loss of consciousness. Along with supportive management in the intensive care unit, she was administered parenteral yohimbine, which resulted in quick recovery and discharge from hospital.

Conclusions
Yohimbine may serve as a useful antidote in severe amitraz intoxication. However, the conclusive benefit of yohimbine in human cases of amitraz poisoning is yet to be established and is a potential area of research.
Poisson–logarithmic half-logistic distribution with inference under a progressive-stress model based on adaptive type-II progressive hybrid censoring
Authors: Hashem Atef F. , Kuş Coşkun , Pekgör Ahmet , Abdel-Hamid Alaa H. 
Published: July 2022

AbstractThe researchers, engineers, and physical experimenters may face difficulty to get a distribution that fits the failure data arising from certain systems. So, in this paper, a new distribution is introduced, named Poisson–logarithmic half-logistic distribution, based on a parallel–series system’s failure times. Specific statistical properties are investigated for the introduced distribution. Also, two real data sets are considered to compare the introduced distribution with some other distributions. The progressive-stress accelerated life test is applied using an increasing exponential function of time to units whose lifetimes are expected to follow the new distribution at normal stress conditions. Different estimation methods, such as maximum likelihood, percentile, least squares, and weighted least square methods, are considered on the basis of adaptive type-II progressive hybrid censoring. To assess the efficiency of the estimation methods, a simulation study is conducted, as well as numerical calculations.