bluuebunny/crossref_metadata_2025_split huggingface dataset:
18F-FDG uptake of visceral adipose tissue on preoperative PET/CT as a predictive marker for breast cancer recurrence
Authors: Kim Hyun Jeong , Kim Dooreh , Bae Soong June , Ahn Sung Gwe , Jeong Joon , Park Woo-Chan , Ryu Young Hoon , Jeon Tae Joo , Lee Yangkyu , Cha Yoon Jin , Yoon Chang Ik 
Published: December 2022

AbstractGlucose utilization by visceral adipose tissue (VAT) reflects inflammatory activity, which also promotes tumor growth and carcinogenesis. The effect of metabolically active VAT on survival outcomes in breast cancer is unknown. We investigated survival outcomes in patients with breast cancer based on the standardized uptake value (SUV) of VAT (SUVmean-VAT) using 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT). A total of 148 patients with breast cancer were divided into high- and low groups according to their SUVmean-VAT and SUVmax-tumor. Clinical characteristics and survival outcomes were compared between the groups. High SUVmean-VAT was associated with poor recurrence-free survival (RFS; hazard ratio [HR], 2.754; 95% confidence interval [CI], 1.090–6.958, p = 0.032) and distant metastasis-free survival (DMFS; HR, 3.500; 95% CI, 1.224–10.01, p = 0.019). Multivariate analysis showed that high SUVmean-VAT was a significant factor for poor RFS and poor DMFS (p = 0.023 and 0.039, respectively). High SUVmax-tumor was significantly associated with short RFS (p = 0.0388). Tumors with a high SUV tended to have a short DMFS, although the difference was not significant (p = 0.0718). Our findings showed that upregulated glucose metabolism in the VAT measured using 18F-FDG PET/CT may be a prognostic biomarker for adverse outcomes in breast cancer.
Early initiation of breastfeeding is inversely associated with public and private c-sections in 73 lower- and middle-income countries
Authors: Vaz Juliana S. , Gatica-Domínguez Giovanna , Neves Paulo A. R. , Vidaletti Luís Paulo , Barros Aluísio J. D. 
Published: December 2022

AbstractAlthough studies in low- and middle-income countries (LMICs) have examined the effects of c-sections on early initiation of breastfeeding (EIBF), the role of the place of birth has not yet been investigated. Therefore, we tested the association between EIBF and the type of delivery by place of birth. Data from 73 nationally representative surveys carried out in LMICs between 2010 and 2019 comprised 408,013 women aged 15 to 49 years. Type of delivery by place of birth was coded in four categories: home vaginal delivery, institutional vaginal delivery, c-section in public, and c-section in private health facilities. We calculated the weighted mean prevalence of place of birth and EIBF by World Bank country income groups. Adjusted Poisson regression (PR) was fitted taking institutional vaginal delivery as a reference. The overall prevalence of EIBF was significantly lower among c-section deliveries in public (PR = 38%; 95% CI 0.618–0.628) and private facilities (PR = 45%; 95% CI 0.54–0.566) compared to institutional vaginal deliveries. EIBF in c-sections in public facilities was slightly higher in lower-middle (PR = 0.650, 95% CI 0.635–0.665) compared to low (PR = 0.544, 95% CI 0.521–0.567) and upper-middle income countries (PR = 0.612, 95% CI 0.599–0.626). EIBF was inversely associated with c-section deliveries compared to institutional vaginal deliveries, especially in private facilities compared to public ones.
Non-contact diagnosis of sleep breathing disorders using infrared optical gas imaging: a prospective observational study
Authors: An Jun Young , Shin Hyun Joon , Yang Myunghyun , Park Do-Yang , Yang Jisun , Kim Hyun Jun 
Published: December 2022

AbstractFull-night polysomnography (PSG) is the gold standard for diagnosing obstructive sleep apnea (OSA). However, PSG requires several sensors to be attached to the patient’s body, which can interfere with sleep. Moreover, non-contact devices that utilize impulse radio ultra-wideband radar have limitations as they cannot directly measure respiratory airflow. This study aimed to detect respiratory events through infrared optical gas imaging and verify its feasibility for the diagnosis of OSA. Data collection through PSG and infrared optical gas imaging was simultaneously conducted on 50 volunteers. Respiratory airflow signal was extracted from the infrared optical gas images using an automated algorithm. We compared the respiratory parameters obtained from infrared optical gas imaging with those from PSG. All respiratory events scored from the infrared optical gas imaging were strongly correlated with those identified with standard PSG sensors. Based on a receiver operating characteristic curve, infrared optical gas imaging was deemed appropriate for the diagnosis of OSA. Infrared optical gas imaging accurately detected respiratory events during sleep; therefore, it may be employed as a screening tool for OSA.
Steroid treatment suppresses the CD4+ T-cell response to the third dose of mRNA COVID-19 vaccine in systemic autoimmune rheumatic disease patients
Authors: Maliah Avishai , Parikh Roma , Tayer-Shifman Oshrat E. , Kimhi Oded , Gepstein Raz , Halperin Tami , Levy Yair , Levy Carmit , Pri-Paz Basson Yael , Kivity Shaye 
Published: December 2022

AbstractProlonged steroid treatment has a suppressive effect on the immune system, however, its effect on the cellular response to mRNA vaccine is unknown. Here we assessed the impact of prolonged steroid treatment on the T-cell and humoral response to the SARS-CoV-2 spike (S) peptide following the third dose of the BNT162b2 vaccine in systemic autoimmune rheumatic disease patients. We found that CD4 T-cell response to the S peptide in patients on high-dose long-term steroid treatment showed significantly less S-peptide specific response, compare to low-dose or untreated patients. Remarkably, these results were not reflected in their humoral response, since almost all patients in the cohort had sufficient antibody levels. Moreover, S-peptide activation failed to induce significant mRNA levels of IFNγ and TNFα in patients receiving high-dose steroids. RNA-sequencing datasets analysis implies that steroid treatments' inhibitory effect of nuclear factor kappa-B signaling may interfere with the activation of S-specific CD4 T-cells. This reveals that high-dose steroid treatment inhibits T-cell response to the mRNA vaccine, despite having sufficient antibody levels. Since T-cell immunity is a crucial factor in the immune response to viruses, our findings highlight the need for enhancing the efficiency of vaccines in immune-suppressive patients, by modulation of the T-cell response.
Intravenous thrombolysis before thrombectomy in acute ischemic stroke: a dual centre retrospective cohort study
Authors: EL Malky Islam , Abdelhafiz Mahmoud , Abdelkhalek Hazem Mo. 
Published: December 2022

AbstractFirst pass effect (FPE) is a successful recanalization (mTICI ≥ 2b) after the first trial of thrombectomy. It is associated with good functional outcomes. Few studies discussed the effect of BT (bridging therapy: combined I.V. thrombolysis and mechanical thrombectomy) on FPE and clinical outcomes. In our study, we would like to report the effect of MT with or without preceding IVT on FPE and the functional outcome of AIS (Acute Ischemic Stroke) of anterior circulation in real practice. A dual-center retrospective cohort study enrolled 201 patients with AIS of anterior circulation and was divided into a bridging therapy (BT) group of 150 patients who received alteplase preceding thrombectomy, and a direct mechanical thrombectomy (dMT) group of 51 patients. Comparisons between both groups regarding the clinical and radiological outcome. Early better clinical outcome (mRS ≤ 2) at day seven with BT group (39.3%) rather than dMT (23.5%) with P value = 0.044. No significant differences as regard puncture to revascularization time, successful revascularization (mTICI) ≥ 2b and FPE between both groups (P value: 0.328, 0.538, and 0.708, respectively). No differences as regards hemorrhagic transformation, mortality rate, and 90-day favorable outcome between both groups (P value 0.091, 0.089, and 0.192, respectively). BT might have better early outcome than dMT but no difference as regards 90-day favorable outcomes, mortality, sICH, FPE, recanalization rate and procedure time. It might be reasonable to go directly to mechanical thrombectomy without IVT for AIS with large vessel occlusion.
Health literacy in gastrointestinal diseases: a comparative analysis between patients with liver cirrhosis, inflammatory bowel disease and gastrointestinal cancer
Authors: Kaps Leonard , Omogbehin Lea , Hildebrand Katharina , Gairing Simon J. , Schleicher Eva M. , Moehler Markus , Rahman Fareed , Schattenberg Jörn M. , Wörns Marcus-Alexander , Galle Peter R. , Labenz Christian 
Published: December 2022

AbstractCurrently, there are only few data on health literacy in patients with chronic gastrointestinal diseases such as gastrointestinal cancer, inflammatory bowel disease (IBD) and, in particular, liver cirrhosis available. Moreover, head-to-head comparisons between patients with these different diseases are lacking. In this study, 379 patients were enrolled. Of these, 102 patients had gastrointestinal cancer, 86 had IBD, and 191 had cirrhosis. Health literacy was quantified using the Health Literacy Questionnaire (HLQ) developed by Osborne et al. (Swinburne University, Australia) and was compared between these three groups. Patients with cancer had the best health literacy across all nine subscales of the HLQ, while patients with cirrhosis had the poorest. In detail, patients with cirrhosis had significantly poorer health literacy than patients with cancer or IBD in subscales such as “feeling understood and supported by healthcare providers”, “having sufficient information to manage my health”, “appraisal of health information”, “ability to actively engage with healthcare providers” or “understanding health information well enough to know what to do” (p < 0.05 for cirrhosis versus IBD or cancer, respectively). In conclusion, health literacy differs remarkably between patients with chronic gastrointestinal diseases such as cirrhosis, IBD or gastrointestinal cancers.
The deubiquitinating enzyme complex BRISC regulates Aurora B activation via lysine-63-linked ubiquitination in mitosis
Authors: Li Qin , Ma Yanfang , Chang Fen , Xu Yongjie , Deng Jingcheng , Duan Junyi , Jiang Wei , He Qihua , Xu Luzheng , Zhong Lijun , Shao Genze , Li Li 
Published: December 2022

AbstractFaithful chromosome segregation requires bi-oriented kinetochore-microtubule attachment on the metaphase spindle. Aurora B kinase, the catalytic core of the chromosome passage complex (CPC), plays a crucial role in this process. Aurora B activation has widely been investigated in the context of protein phosphorylation. Here, we report that Aurora B is ubiquitinated in mitosis through lysine-63 ubiquitin chains (K63-Ub), which is required for its activation. Mutation of Aurora B at its primary K63 ubiquitin site inhibits its activation, reduces its kinase activity, and disrupts the association of Aurora B with other components of CPC, leading to severe mitotic defects and cell apoptosis. Moreover, we identify that BRCC36 isopeptidase complex (BRISC) is the K63-specific deubiquitinating enzyme for Aurora B. BRISC deficiency augments the accumulation of Aurora B K63-Ubs, leading to Aurora B hyperactivation and erroneous chromosome–microtubule attachments. These findings define the role of K63-linked ubiquitination in regulating Aurora B activation and provide a potential site for Aurora B-targeting drug design.
Disentangling structural and kinetic components of the α-relaxation in supercooled metallic liquids
Authors: Neuber Nico , Gross Oliver , Frey Maximilian , Bochtler Benedikt , Kuball Alexander , Hechler Simon , Yang Fan , Pineda Eloi , Westermeier Fabian , Sprung Michael , Schäfer Florian , Gallino Isabella , Busch Ralf , Ruta Beatrice 
Published: December 2022

AbstractThe particle motion associated to the α-relaxation in supercooled liquids is still challenging scientists due to its difficulty to be probed experimentally. By combining synchrotron techniques, we report the existence of microscopic structure-dynamics relationships in Pt42.5Cu27Ni9.5P21 and Pd42.5Cu27Ni9.5P21 liquids which allows us to disentangle structural and kinetic contributions to the α-process. While the two alloys show similar kinetic fragilities, their structural fragilities differ and correlate with the temperature dependence of the stretching parameter describing the decay of the density fluctuations. This implies that the evolution of dynamical heterogeneities in supercooled alloys is determined by the rigidity of the melt structure. We find also that the atomic motion not only reflects the topological order but also the chemical short-range order, which can lead to a surprising slowdown of the α-process at the mesoscopic length scale. These results will contribute to the comprehension of the glass transition, which is still missing.
„Trans* ist plural“ – Reflexionen aus der klinischen Arbeit
Authors: Breu Franziska , Grebe Jörn 
Published: December 2022

ZusammenfassungVor dem Hintergrund ihrer Tätigkeit in der Spezialsprechstunde für Geschlechtsdysphorie in der Kinder- und Jugendpsychiatrie am Universitätsklinikum Hamburg-Eppendorf wenden sich die Autor*innen Fragen rund um die Komplexität und Heterogenität in der Behandlung von geschlechtsdysphorischen Kindern und Jugendlichen – insbesondere in der frühen Adoleszenz – zu. Hierbei wird der spannungsreiche Spagat zwischen der Notwendigkeit, als Behandler*in einen reflexiven Verstehensprozess der jeweils individuellen Geschlechtsdysphorie und/oder Transidentität anzustoßen, sowie dem oftmals zentralen Wunsch nach einer zeitnahen Indikation körpermedizinischer Maßnahmen aufseiten der Patient*innen diskutiert. Die Autor*innen plädieren für eine neutrale, offene Haltung gegenüber den vielschichtigen Konflikten, Belastungen und komplexen Symptomatiken der Jugendlichen, um eine verantwortungsvolle Entscheidung für Transitionsschritte treffen zu können.
Ablehnen, Anprangern, Beleidigen: Sexualitätsbezogene Meinungsdynamiken im Internet
Authors: Lemke Richard 
Published: December 2022

ZusammenfassungZu Beginn des Beitrags werden drei Beispiele vorgestellt, anhand derer die Spezifika sexualitätsbezogener Meinungsdynamiken im Internet illustriert werden. Speziell Meinungsäußerungen auf Social-Media-Seiten können aufgrund der gesteigerten Redebereitschaft im Internet sowie ihrer Rolle bei der Schätzung von Meinungsverteilungen als ein Katalysator in sexualitätsbezogenen Meinungsdiskursen fungieren: Sie können Minderheitsmeinungen und Versprachlichung von Sexualität begünstigen, gleichzeitig aber auch durch Empörungswellen und personifizierte Angriffe andere zur Verstummung bringen. Es wird anschließend für eine Verstärkung der demoskopischen Erforschung sexualitätsbezogener öffentlicher Meinung argumentiert, weil der öffentlichen Meinung im Rahmen von Sexualität verschiedene Funktionen zukommen: Sie trägt zur Ausformung von Engagement in gesellschaftlichen Debatten bei, bildet eine Komponente des (sexuellen) Minderheitenstresses in einer Gesellschaft und stellt – auch mit Blick auf Scham – einen Bewertungsrahmen sexueller Handlungen dar. Der Beitrag schließt mit Empfehlungen für Wissenschaft, Bildung und Praxis.
Stress und Alterung
Authors: Wolf Alfred 
Published: December 2022

ZusammenfassungDer biologische Alterungsprozess besteht aus Änderungen von molekularen
Strukturen und deren Funktionen bei unzureichenden Reparaturmechanismen. Dieser
katabole Prozess fördert die Vulnerabilität für
altersabhängige Erkrankungen wie degenerative Gehirnerkrankungen.
Verstärkend wirken dabei chronischer Stress, psychische Belastung,
Genetik/Epigenetik, endokrine Alterung und bestimmte Lebensstilfaktoren.
Dauerhaft verstärkte Stressexposition verändert den gesamten
Zellstoffwechsel und erhöht dadurch das Risiko für den Verlust
von physischer und emotionaler Lebensqualität, organischer
Gesamtfunktion und Mortalität.
Ophthalmological Findings in Joubert Syndrome and Related Disorders
Authors: Ceravolo Ida , Granata Francesca , Gitto Eloisa , Iapadre Giulia , Chimenz Roberto , Giannitto Nino , Mancuso Alessio , Ceravolo Maria Domenica , Macchia Tommaso La , Rissotto Federico , Farello Giovanni , Cuppari Caterina 
Published: December 2022

AbstractJoubert syndrome (JS) is a rare genetic condition characterized by congenital malformation of the mid-hindbrain, cerebellar ataxia, hypotonia, oculomotor apraxia, hypoplasia of the cerebellar vermis resulting in breathing defects, ataxia, and delayed development. Ophthalmological examination reveals eye involvement with nystagmus and retinal defects. Genetic counseling is important for the prevention of new cases. Great advances have been made in recent years. Management is symptomatic and multidisciplinary. In the present review, we discussed the most frequent ophthalmological anomalies associated with JS and speculated on the role of ciliary physiology in eye development.
Ionization-induced optical heterogeneity and ion-like direct emission in 1-nm silicon nanoparticle grains: Prospect for fast optical modulation
Authors: Mantey Kevin , Morgan Huw , Nayfeh Ammar , Bahceci Ersin , Nayfeh Munir H. 
Published: December 2022

Silicon, a highly symmetric and homogeneous material, does not exhibit fast optical modulation. Recent classical electrodynamics simulations, however, demonstrated transient optical heterogeneity in silicon nanostructures, in which a high-density of excitonic electron–hole pair plasma and charge is created. The phenomenon, however, requires a specific particle size (∼100 nm diameter) and a high-density (1023/cc) plasma. We examine here the quantum aspect of the heterogeneity in 1-nm Si nanoparticles. Due to the small number of atoms, 1 nm nanoparticles are amenable to the Hartree–Fock first principle atomistic quantum theory simulations procedure, while single ionization events are sufficient to provide high charge density (2 × 1021/cc). The simulations show that the charge distribution in singly charged 1-nm particles is nonlinear and heterogeneous, accompanied with structural distortion that produces an electric dipole moment. Electronically, the simulations show that the single charge induces stationary Coulomb states that riddle the bandgap of the neutral particle, with dipole-allowed transitions, effectively inducing partial conducting-like behavior. Optically, when the charge is produced by ionizing UV radiation, the ionized particle survives and exhibits both extended (wide-band) as well as atomic- or ion-like sharp emission, in agreement with infrared polarimetry and spectroscopy observations in the solar coronal holes, as well as under synchrotron irradiation. Not only do ionized Si nanoparticles (charged nanosilicon grains) afford fast optical modulations, but they may also prove pivotal for understanding features of interstellar medium, observed throughout the Milky Way and other galaxies, including spectroscopic and material composition, as well as neutral hydrogen abundancy.
Spin Hall nano-oscillators based on synthetic skyrmions imprinted in Co nanodisc
Authors: Choi Byoung , Aryal Mukesh , Rasmussen Ben , Choi Minyeong , Hong Yang-Ki 
Published: December 2022

Spin Hall nano-oscillators utilizing the synthetic spin textures imprinted in nanomagnets are demonstrated by numerical investigations. The imprinting is achieved by locally manipulating the magnetic anisotropy and the interfacial Dzyaloshinskii–Moriya interaction (DMI). The resulting spin texture is equivalent to a Néel-type skyrmion and is topologically stable to thermal fluctuations at finite temperatures. The eigenoscillation of the synthetic skyrmion can be activated by the spin-orbit torques induced by the spin Hall effect, and an eigenfrequency of up to ∼1.5 GHz is achieved. The eigenmode of the skyrmion resonance is found to be associated with the counter-clockwise rotational motion of the local magnetization. Our result demonstrates the working principle of using synthetic nanomagnets in spintronics applications.
Fidelity or infidelity?
Authors: Yoon Sun Kyoung 
Published: December 2022

Abstract
This article examines the controversy over The Vegetarian (Han 2015), Deborah Smith’s English translation of Han Kang’s Korean novel,
채식주의자 Chaesikjuuija (2007). The translation, winner of the Man Booker International Prize in 2016, provoked a heated discussion in South Korea. A close analysis of three influential articles – Cho (2017), B. Kim (2017), and W. Kim (2018) – shows how the debates on the supposed mistranslation of The Vegetarian are dominated by a preoccupation with fidelity and literal translation. They dismiss the translator’s interpretation or transformation, regarding accuracy or fidelity as the sole criterion for a good translation. Significantly, the critics’ advocacy of literal translation, and hence their objections to The Vegetarian, reflect three levels of political anxiety: over ‘superior’ translation, over ‘English’ translation, and over a female translator’s ‘feminist’ translation.
Multi-mode Bus Coupling Architecture of Superconducting Quantum Processor
Authors: Zhao Changhao , He Yongcheng , Geng Xiao , He Kaiyong , Dai Genting , Liu Jianshe , Chen Wei 
Published: December 2022

Abstract
Resonators in circuit quantum electrodynamics systems naturally carry multiple modes, which may have non-negligible influence on qubit parameters and device performance. While new theories and techniques are under investigation to deal with the multi-mode effects in circuit quantum electrodynamics systems, novel engineering designs are also proposed featuring multi-mode resonators to achieve enhanced functionalities of superconducting quantum processors. In this work, multi-mode bus coupling architecture is proposed, in which superconducting qubits are coupled to multiple bus resonators to gain larger coupling strength. Application of multi-mode bus coupler can help improve iSWAP gate fidelity and gate speed beyond the limit of single-mode scenario. The proposed multi-mode bus coupling architecture is compatible with a scalable variation of the traditional bus coupling architecture. It opens up new possibilities for realization of scalable superconducting quantum computation with circuit quantum electrodynamics systems.
Al-fumarate metal-organic frameworks adsorbent for removal of organic compound and gas storage
Authors: Loan Nguyen Thu , Thi Hiep Nguyen , Thi Thu Huong Tran , Thi Dieu Thuy Ung , Thi Thuong Huyen Tran , Le Hoang Tan Doan , Liem Nguyen Quang 
Published: December 2022

Abstract
Metal-organic frameworks (MOFs) have attracted a great amount of attention due to their unique properties, including high porosity, large surface area, and flexible frameworks. These special properties are desirable in many applications such as adsorption, catalysis, drug delivery, and gas storage. Herein, Al-fumarate MOFs were synthesised from the reaction of aluminium sulphate with fumaric acid at 65 °C for 1 h. X-ray diffraction (XRD), N2-adsorption, scanning electronic microscope (SEM), thermogravimetric analysis (TGA), and UV–vis spectrometer were used to characterise the physicochemical properties of the prepared adsorbent materials. The obtained results indicated that the Al-fumarate MOFs possess good water stability and can adsorb/remove over 70% of Rose Bengal under UV–light irradiation. Gas adsorption/storage experiments revealed that Al-fumarate MOFs also exhibited high CO2 and CH4 uptakes of ∼59 cm3 g−1 and 17 cm3 g−1 at 303 K and ∼805 Torr (∼1 bar), respectively. The synthesised Al-fumarate MOFs obtained both excellent photocatalytic activity and high gas adsorption/storage that are due to the large surface area (∼1100 m2 g)−1 and high porosity (0.65 cm3 g)−1. Thus, these Al-fumarate MOFs are very promising in the fields of photocatalysis for wastewater treatment and of gas adsorption/storage.