bluuebunny/crossref_metadata_2025_split huggingface dataset:
The influence of intensity and neuropathic component of pain syndrome on the quality of life in patients with multiple sclerosis
Authors: Nehrych T. I. , Bozhenko N. L. , Bozhenko M. I. 
Published: January 2022

The aim of the work. To analyze the influence of intensity and neuropathic component of pain syndrome on the quality of life structure characteristics in patients with multiple sclerosis (MS).
Materials and methods. 104 MS patients with different types of MS course and complaints of pain during the last month were examined in the Lviv Regional Multiple Sclerosis Center. The patients were interviewed using standardized questionnaires (Pain Detect, VAS, SF-36) followed by an analysis of the pain characteristics influence on the quality of life.
Results. When assessing the influence of the main characteristics of MS course, the relationship between the physical component of quality of life and levels of disability (EDSS) and the total number of relapses was found (r = -0.60, P < 0.01; r = -0.34, P < 0.01, respectively). However, the mental component of quality of life had no significant relationship with the level of disability and the number of relapses. The average pain intensity within a month on the VAS scale was 5.0 [4.0; 7.0]. 24.0 % of patients had low-intensity pain, 54.8 % – moderate, 21.2 % – high. In MS patients with low-intensity pain within a month, 5 of the 11 quality of life indicators were significantly higher, in particular, the overall physical component of quality of life – 38.1 [33.8; 48.5] % in low-intensity pain against 31.8 [28.1; 38.7] %, P = 0.02 – in moderate. In MS patients, the level of both physical (r = -0.25; P = 0.01) and mental (r = -0.21; P = 0.03) component of quality of life decreased with increasing pain intensity. The most notable correlation was observed between intensity of pain and such characteristics of quality of life as energy/fatigue (r = -0.37; P ˂ 0.01) and emotional well-being (r = -0.28; P ˂ 0.01). In 30.8 % of patients, pain was neuropathic, in 47.1 % – nociceptive, in 22.1 % – undetermined. MS patients with the neuropathic type of pain had significantly lower scores, 7 out of 11 indicators of quality of life, largely the mental component, than scores in MS patients with nociceptive type (Р < 0.05). Correlation analysis showed the association between an increase in the manifestation of neuropathic pain component and a decrease in all quality of life characteristics, except in health change. In MS patients with a neuropathic component, in increasing level of its manifestation, the mental component of health decreased clearly (r = -0.36; P ˂ 0.01), namely its social functioning characteristic (r = -0.35; P < 0.01).
Conclusions. In MS patients, increasing intensity of pain decreases both physical and mental components of quality of life with the most significant decrease in energy/fatigue and emotional well-being as parts of the mental component of quality of life. The neuropathic component of pain and the level of its manifestation are largely associated with a decrease in the mental component of quality of life as the overall indicator and social functioning as its structural element.
Pantothenate kinase-associated neurodegeneration (Hallerworden–Spatze disease): clinical aspects, diagnosis, treatment (literature review and own data)
Authors: Antypkin Yu. H. , Kyrylova L. H. , Miroshnykov O. O. , Yuzva O. O. , Silaieva L. Yu. , Berehela O. V. , Myroniak L. A. 
Published: January 2022

Aim. To analyze current data of scientific literature on the etiology, pathogenesis, approaches to the diagnosis and treatment of rare orphan disease – pantothenate kinase-associated neurodegeneration and to describe the clinical case of this disease.
Pantothenate kinase-associated neurodegeneration (PKAN) is a rare inherited autosomal recessive disorder caused by mutations in the PANK2 gene, which is located at the chromosomal locus: 20p13-p12.3.
The article presents a literature review and a case report of the diagnosis and treatment of 8-year-old girl with pantothenate kinase-associated neurodegeneration who suffered from progressive motor impairment.
Among the dominant clinical manifestations is a growing extrapyramidal motor disorder, the so-called “dystonic storm”, which can range from severe sensorimotor motor deficits in infants and young children to mild parkinsonism in adults. MRI signs in the form of specific changes in the T2-weighted mode, which detects typical areas of hyperintensive signal in globus pallidus, surrounded by a border of hypointensive signal (“tiger’s eye”) are particular important. Neuroimaging data most likely make possible to suspect a correct diagnosis, reducing the time and cost of additional examinations.
There is no pathogenetic treatment of this disease now. The main directions of currently available symptomatic drug therapy are described. Clinical trials of detoxifying drugs that reduce iron levels in the body (chelation) and surgical treatments are currently underway.
Conclusions. The presented clinical observation once again confirms the complexity of the diagnostic search for orphan diseases of the nervous system. A key place in the diagnosis of pantothenate kinase-associated neurodegeneration belongs to the neuroimaging methods and molecular genetic testing data.
A new minimally invasive surgical technique for the treatment of ovarian cysts in children
Authors: Spakhi O. V. , Zaporozhchenko A. H. , Morhun V. V. , Pakholchuk O. P. 
Published: January 2022

The topical issue of pediatric surgery is the treatment of ovarian cysts based on the development of new technologies for surgical correction of the disease.
Aim. To analyze the effectiveness of using a new minimally invasive method for removal of cystic ovarian neoplasms in children.
Material and methods. A retrospective analysis of 77 female patients with ovarian cysts, aged from 3 months to 17 years, was carried out. The patients were divided into 3 groups depending on the various surgical techniques used for their treatment. Group I consisted of 32 (41 %) girls who underwent cystectomy according to the new transabdominal technique for removing ovarian cysts in children. Group II included 19 (25 %) children who underwent a laparoscopic surgery. Group III comprised 26 (34 %) children who underwent a hybrid laparoscopy-assisted cystectomy. The following indicators were analyzed: the age of patients, the nature and number of complications of the disease course, the size of cystic neoplasms, the duration of surgical interventions, the number of cases accompanied by cyst contents leaking into the abdominal cavity during surgical manipulations, and the length of hospital stay.
Results. The mean age of all patients was 11.23 ± 0.57 years. Planned hospitalizations amounted to 46 (59.7 %) cases. The duration of surgery in group I was almost 1.5 times lower (P < 0.05) than that in patients of group II and 2 times shorter than in children of group III (P < 0.05). Free cyst contents leaking into the abdominal cavity was observed in 35 (91.4 %) patients of Group III, which required additional measures aimed at the abdominal cavity sanation. The proposed minimally invasive transabdominal surgical technique prevented this complication in all 32 patients of Group I. The length of hospital stay did not differ significantly (P > 0.05) between children groups I and II and did not exceed 7.50 ± 0.35 (M ± SEM) days. This indicator was almost 1.5 times higher in Group III patients.
Conclusions. The new minimally invasive transabdominal method for removing cystic ovarian neoplasms in children provided minimal trauma with maximum ablasticity and cosmetic effect of the operation. The proposed technique made it possible to prevent the development of intraoperative and postoperative complications, significantly reduce the duration of surgery and the recovery time of patients.
Quercetin effectiveness in patients with COVID-19 associated pneumonia
Authors: Zupanets I. A. , Holubovska О. А. , Tarasenko O. O. , Bezuhla N. P. , Pasichnyk M. F. , Karabynosh S. O. , Kopcha V. S. , Moroz L. V. , Maksymchuk H. V. , Kobrynska O. Ya. , Fishchuk R. M. , Schulha D. I. , Morochkovskyj R. S. , Zoshchak M. S. 
Published: January 2022

The aim of this work was to evaluate the effectiveness of quercetin addition to the treatment regimen for patients with COVID-19 associated pneumonia.
Materials and methods. The effectiveness of two dosage forms of quercetin was studied in 200 patients, who were divided equally into the main and control groups. The main group patients received quercetin in addition to the basic therapy: intravenous drip of Quercetin/Polyvinylirolidone during the first 10 days followed by oral administration of Quercetin/Pectin over the next 10 days. Patients from the control group received only the basic therapy drugs.
The study evaluated the dynamics of the disease symptoms (saturation level, respiratory rate, body temperature, cough, general weakness), as well as laboratory markers (C-reactive protein (CRP), ferritin, D-dimer).
Results. Two dosage forms of quercetin consistently used in addition to the basic therapy improve pulmonary gas exchange and accelerate the lung function recovery. This is evidenced by a statistically significant majority of patients with positive dynamics in the symptoms of “Saturation level” and “Cough” as well as the meeting a complex indicator of the therapy effectiveness 2 days earlier than in the control group. The treatment regimen applied also helps to stabilize the level of D-dimer in the blood of the main group patients.
Conclusions. The use of two dosage forms of quercetin in addition to the basic therapy accelerates the recovery of patients with coronavirus disease associated pneumonia and can help to prevent the progression of COVID-19 associated coagulopathy.
Effect of long-term training on heart rate variability, central hemodynamics and physical working capacity in female swimmers with different sports qualifications
Authors: Mykhaliuk Ye. L. , Syvolap V. V. , Horokhovskyi Ye. Yu. 
Published: January 2022

The aim of this study was to compare the indices of heart rate variability, central hemodynamics and physical working capacity in female swimmers with different sports qualifications.
Materials and methods. The indices of heart rate variability (HRV), central hemodynamics (CH) and physical development (PD) were studied in 44 female swimmers (mean age 15.00 ± 0.36 years, swimming experience – 7.40 ± 0.35 years) depending on their sports qualifications (MSIC, MS, CMS, first- and second-class athletes). To analyze the autonomic regulation of cardiac activity, power spectral and time-domain indices of HRV were used. CH were examined by the method of automated tetrapolar rheography according to W. Kubiček et al. (1970) in Y. T. Pushkar’s et al. modification (1970). Physical working capacity was measured according to the generally accepted technique on a cycling ergometer using the PWC170 submaximal test. The functional state index (FSI) was calculated using the formula patented by authors.
Results. Significant differences were found between the indices of HRV, CH and PD in female swimmers with different qualifications. Thus, in the athletes with the MSIC–MS sports qualifications, heart rate was 61.0 ± 3.8 bpm, cardiac index (CI) – 2.978 ± 0.098 L·min-1·m-2 (there was a trend towards the eukinetic type of hemodynamics (TH)), stress index (SI) – 51.16 ± 12.66 relative units (r.u.), PWC170/kg – 16.98 ± 1.22 kgm·min-1·kg-1, FSI – 6.511 ± 0.422 r.u. A decrease in heart rate among them was correlated with a decrease in SI, and an increase in Mo – with a decrease in CI. In female CMS swimmers, heart rate was 61.37 ± 2.83 beats/min-1, CI – 3.021 ± 0.112 l -1min -1·m -2 , a trend towards the predominantly eukinetic TH, SI – 53.73 ± 9.41 r.u., PWC170 /kg– 14.66 ± 0.683 kgm·min-1·kg -1, FSI – 5.683 ± 0.324 r.u. Reduced values of SI and CI were associated with increased values of Mo and PWC170/kg. In first- and second-class female swimmers, heart rate was 63.05 ± 2.22 beats/min, SI – 50.62 ± 6.4 r.u. This group tended to be eytonic and eukinetic. The mean value of the PWC170/kg was 14.19 ± 0.589 kgm·min-1·kg-1 and FSI – 5.953 ± 0.337 r.u. Correlation analysis confirmed the relationship between the decrease in heart rate and CI and the increase in Mo and PWC170/kg.
Conclusions. Long-term training in female swimmers at the distance of 50 to 200 meters is accompanied by the significant increase in the PWC170/kg values with qualification improving, 14.19 ± 0.589 kgm·min-1·kg-1, 14.66 ± 0.683 kgm·min-1·kg-1; 16.98 ± 1.22 kgm·min-1·kg-1, respectively, improvements in HRV (decrease in stress index and increase in Mo) and decrease in CI.
Metodologia archeologii/prahistorii profesora dr. hab. Jana Żaka (1923–1990) po 30 latach. Między modernistycznymi dążeniami a postmodernistyczną rzeczywistością
Authors: Minta-Tworzowska Danuta 
Published: January 2022

January 4, 2020 was the 30th anniversary of the death of Professor Jan Żak, who died prematurely at the age of 67. His work and scientific activities were known and appreciated in various countries and during difficult times when he was professionally involved in archeology. The biography of Professor Jan Żak resulted largely from the spirit of the times in which he lived, but also from his open, curious personality. He touched the warfare, and his professional life took place in the realities of the People's Republic of Poland; he also witnessed its dramatic end. The aim of this article is not only to recall the methodological and theoretical foundations of J. Żak's scientific work, but also to try to answer the question about the contemporary methodology of archeology, practiced by the Professor's students and subsequent generations.
Diversity Through Bureaucracy: System Judges and Intersectional Diversification of the Israeli Judiciary
Authors: Jasper Alon 
Published: January 2022

Abstract
This article examines the role bureaucracy has in enhancing the social diversity of judiciaries. It does so by analyzing the Israeli judiciary and its reforms over the last three decades, and the interaction of these reforms with the appearance of intersectional judges—Arab women, Jewish women of Orthodox background, and Jewish women from geographic and economic peripheries—into the Israeli judiciary. Based on an original empirical study, the article shows that the career paths of intersectional judges include administrative roles in the judiciary more often than non-intersectional judges. The article further demonstrates how these administrative career paths were shaped by bureaucratic-minded reforms. The Israeli case study thus shows how the bureaucratic design of the judiciary can accommodate diversity efforts, sometimes unintendedly, and discusses the merits, boundaries, and drawbacks of such bureaucratic design.
Molecular chirality detection using plasmonic and dielectric nanoparticles
Authors: Kim TaeHyung , Park Q-Han 
Published: January 2022

Abstract
Nanoscale particles and structures hold promise in circular dichroism (CD) spectroscopy for overcoming the weakness of molecular CD signals. Significant effort have been made to characterize nanophotonic CD enhancement and find efficient ways to boost molecular chirality, but the best solution is yet to be found. In this paper, we present a rigorous analytic study of the nanophotonic CD enhancement of typical nanoparticles. We consider metallic and dielectric nanoparticles capped with chiral molecules and analyze the effect of multipolar nanoparticles on the molecular CD. We identify the spectral features of the molecular CD resulting from the electric and magnetic resonances of nanoparticles and suggest better ways to boost molecular chirality. We also clarify the contribution of particle scattering and absorption to the molecular CD and the dependence on particle size. Our work provides an exact analytic approach to nanophotonic CD enhancement and offers a rule for selecting the most efficient particle for sensitive molecular chirality detection.
The Bureau and the Realism of Spy Fiction
Authors: Blistène Pauline 
Published: January 2022

Abstract
This article addresses the issue of realism in relationship to contemporary serial fiction. Drawing on The Bureau (Canal+, 2015–2020), it argues that spy TV series are “realistic” not because they correspond to reality but because of their impact on reality. It begins by giving an overview of the many ways in which “realism,” in the ordinary sense of a resemblance with reality, served as the working framework for The Bureau’s team. It then identifies three distinct types of realisms in the series. The first is a “fictional realism,” namely the ability of The Bureau to conform to the aesthetic and narrative conventions of realistic fictions. The second type of realism, which I qualify as “ordinary,” refers to the possibilities offered by the show’s aesthetics and the enmeshment of The Bureau with viewers’ ordinary experience. The third type of “performative realism” refers to the series’ impact on shared representations and reality. By providing a common language about the secret activities of the state, The Bureau has gone from being a framed version of reality to being one of the defining frameworks through which state secrecy is experienced both individually and collectively, by insiders and the public at large.
Monogenic diabetes due to an INSR mutation in a child with severe insulin resistance
Authors: Sanderson Elaine E , Shah Mark , Hooper Amanda J , Bell Damon A , Choong Catherine S 
Published: January 2022

Summary
We report a case of an 11-year-old girl presenting with a new diagnosis of diabetes associated with a heterozygous missense mutation in the insulin receptor (INSR) gene. This case highlights that INSR gene variants can be a cause for monogenic diabetes in children and adolescents and the need for genetic evaluation in atypical presentations of diabetes. We also describe the possible role of metformin in treating individuals with type A insulin resistance syndrome due to INSR gene variants.

Learning points

Insulin receptor (INSR) gene variants can be a cause of monogenic diabetes in children and adolescents.

Genetic evaluation should be considered in children and adolescents with type 2 diabetes (T2D), particularly where there is an atypical presentation and/or positive family history.

Metformin may have a role in the treatment of type A insulin resistance syndrome due to heterozygous mutation of the INSR gene.
Quality Initiative to Reduce Extrauterine Growth Restriction in Very Low Birth Weight Infants
Authors: Dhanireddy Ramasubbareddy , Scott Patricia A. , Barker Brenda , Scott Theresa A. 
Published: January 2022

Abstract

BACKGROUND
We report a statewide quality improvement initiative aimed to decrease the incidence of extrauterine growth restriction among very low birth weight infants cared for in Tennessee NICUs.

METHODS
The cohort consisted of infants born appropriate for gestational age between May 2016 and December 2018 from 9 NICUs across Tennessee. The infants were 23 to 32 weeks gestation and 500 to 1499 g birth weight. The process measures were the hours of life (HOL) when parenteral protein and intravenous lipid emulsion were initiated, the number of days to first enteral feeding, and attainment of full enteral caloric intake (110–130 kcal/kg per day). The primary outcome was extrauterine growth restriction, defined as weight &lt;10th percentile for weight at 36 weeks postmenstrual age. Statistical process control charts and the Shewhart control rules were used to find special cause variation.

RESULTS
Although special cause variation was not indicated in the primary outcome measure, it was indicated for the reduction in specific process measures: HOL when parenteral protein was initiated, HOL when intravenous lipid emulsion was initiated, and the number of days to attainment of full enteral caloric intake (among the hospitals considered regional perinatal centers).

CONCLUSIONS
A statewide quality improvement initiative led to earlier initiation of parenteral and enteral nutrition and improved awareness of the importance of postnatal nutrition.
The relation of atherosclerotic lesions of BCA against the background of COPD in patients aged 40-60 years. Review of the literature and retrospective analysis
Authors: Andrusyshyna Iryna , Batashova-Galinska Viktoria , Horbenko Tetiana , Kholopov Leonid 
Published: January 2022

The aim: to determine the possible relationship between chronic obstructive pulmonary disease and the presence of atherosclerosis of the brachiocephalic vessels in persons aged 40–60 years for the possibility of early prevention of cardiovascular events.
Materials and methods: to do this, we reviewed articles using open sources such as PubMED, Medscape and Cochrane library, highlighting the relationship between the development of atherosclerosis and the presence and severity of COPD. Also, based on the University Clinic of ONMedU and Military Clinical Center of the Southern Region, a retrospective analysis of patients with an inconclusively confirmed diagnosis of COPD and conducted biochemical blood tests was carried out in order to study changes in the lipid profile and the presence of BCS in these patients.
Result: In the course of a retrospective analysis of patients, a relationship was found between the presence of BCA atherosclerosis and the presence of COPD, and based on the literature data, a parallel was drawn between changes in the lipid profile in patients with COPD. But, in view of the insufficient number of patients, this topic requires additional research.
Conclusions: thus, based on the obtained data, it can be concluded that there is a connection between the presence of COPD, changes in the lipid profile, and the presence of BCА atherosclerosis. This connection can become one of the key mechanisms of early diagnosis of BCА atherosclerosis
Epidemiology and trend of rabies post exposure prophylaxis at anti rabies clinic of a tertiary care hospital in India
Authors: Datta Mousumi 
Published: January 2022

Background and Objectives Effective prevention of rabies is possible by vaccination following a rabid animal bite. Objectives of this study was to describe demographics, circumstances of bite and the trend of vaccination over last three years (January 2019-November 2021) in an anti-rabies clinic of a tertiary care hospital.
Materials and Methods This was an observational study of prospective design. All animal bite victims who attended the anti rabies clinic (ARC) of the study institution during the study period were invited to participate in the study. Data was collected using a structured schedule on first visit and at 28th day to check for on time compliance to vaccination schedule. On time completion was defined as taking all vaccine doses on due dates. Distribution of variables was shown by frequencies and percentages. Indicators were recorded for three consecutive years. Year wise indicators were compared by chi-square test.
Results Data was collected for 293 victims. Median age of bite victims was 41.8 years (range 3-78 years) while 58.7 % respondents were below 45 years of age; 71.3 % victims were male. 82.3 % bites were by dogs; 38 % victims had multiple bites. Post-exposure prophylaxis (PEP) with anti-rabies vaccine (ARV) was initiated within 72 hours for 80 % victims and it was completed on time for 66.2 % victims. Three years trend for PEP indicators did not show a statistically significant difference.
Conclusion On time PEP schedule completion was fairly high at the studied ARC. Health seeking for PEP following animal bite was not affected by the corona virus pandemic