bluuebunny/crossref_metadata_2025_split huggingface dataset:
New constraints on the postglacial shallow-water carbonate accumulation in the Great Barrier Reef
Authors: Hinestrosa Gustavo , Webster Jody M. , Beaman Robin J. 
Published: January 2022

AbstractMore accurate global volumetric estimations of shallow-water reef deposits are needed to better inform climate and carbon cycle models. Using recently acquired datasets and International Ocean Discovery Program (IODP) Expedition 325 cores, we calculated shallow-water CaCO3 volumetrics and mass for the Great Barrier Reef region and extrapolated these results globally. In our estimates, we include deposits that have been neglected in global carbonate budgets: Holocene Halimeda bioherms located on the shelf, and postglacial pre-Holocene (now) drowned coral reefs located on the shelf edge. Our results show that in the Great Barrier Reef alone, these drowned reef deposits represent ca. 135 Gt CaCO3, comparatively representing 16–20% of the younger Holocene reef deposits. Globally, under plausible assumptions, we estimate the presence of ca. 8100 Gt CaCO3 of Holocene reef deposits, ca. 1500 Gt CaCO3 of drowned reef deposits and ca. 590 Gt CaCO3 of Halimeda shelf bioherms. Significantly, we found that in our scenarios the periods of pronounced reefal mass accumulation broadly encompass the occurrence of the Younger Dryas and periods of CO2 surge (14.9–14.4 ka, 13.0–11.5 ka) observed in Antarctic ice cores. Our estimations are consistent with reef accretion episodes inferred from previous global carbon cycle models and with the chronology from reef cores from the shelf edge of the Great Barrier Reef.
Ophthalmic complications in retinopathy of prematurity in the first decade of life in Korea using the national health insurance database
Authors: Hong Eun Hee , Shin Yong Un , Bae Gi Hwan , Choi Young Jin , Ahn Seong Joon , Kim Inah , Cho Heeyoon 
Published: January 2022

AbstractThe aim of this study is to investigate the epidemiology of ophthalmic complications of retinopathy of prematurity (ROP) after preterm birth using population-based database in South Korea. Using the National Health Insurance database, ophthalmic complications among premature infants born in 2007–2008 during their 10-year follow-up period were identified. Annual cumulative incidence rate and period prevalence of complications at each age were analyzed among those with ROP and those who underwent treatment for ROP (tROP). The hazard ratios (HRs) according to the presence of ROP and treatment for ROP were also analyzed. We identified 18,256 premature infants, 6995 of whom had ROP. The prevalence at 10th year for overall ophthalmic complications was 11.1% and 35.9% among ROP and tROP, respectively. Strabismus, amblyopia, and glaucoma were the three most common complications. The presence of ROP was associated with higher risk of complications (HR 1.53, 95%CI 1.44–1.61) among premature infants, and the presence of treatment for ROP was associated with higher risk of complications (HR 4.31, 95%CI 3.74–4.98) among ROP cases. This study reports the nationwide epidemiologic data on ophthalmic complications of ROP during the first decade of life, which will help advance our understandings and establish national strategies in managing ROP.
Adaptive transfer alignment method based on the observability analysis for airborne pod strapdown inertial navigation system
Authors: Chen Weina , Yang Zhong , Gu Shanshan , Wang Yizhi , Tang Yujuan 
Published: January 2022

AbstractFor the airborne pod strapdown inertial navigation system, it is necessary to use the host aircraft's inertial navigation system for the transfer alignment as quickly and accurately as possible in the flight process of the aircraft. The purpose of this paper is to propose an adaptive transfer alignment method based on the observability analysis for the strapdown inertial navigation system, which is able to meet the practical need of maintaining the navigation accuracy of the airborne pod. The observability of each state variable is obtained by observability analysis of system state variables. According to the weight of the observability, a transfer alignment filter algorithm based on adaptive adjustment factor is constructed to reduce the influence of weak observability state variables on the whole filter, which can improve the estimation accuracy of transfer alignment. Simulations and experiment tests of the airborne pod and the master strapdown inertial navigation systems show that the adaptive transfer alignment method based on the observability analysis can overcome the shortage of the weak observability state variables, so as to improve the alignment and the navigation performance in practical applications, thus improving the adaptability of the airborne pod.
Resting state functional connectivity provides mechanistic predictions of future changes in sedentary behavior
Authors: Morris Timothy P. , Kucyi Aaron , Anteraper Sheeba Arnold , Geddes Maiya Rachel , Nieto-Castañon Alfonso , Burzynska Agnieszka , Gothe Neha P. , Fanning Jason , Salerno Elizabeth A. , Whitfield-Gabrieli Susan , Hillman Charles H. , McAuley Edward , Kramer Arthur F. 
Published: January 2022

AbstractSedentary behaviors are increasing at the cost of millions of dollars spent in health care and productivity losses due to physical inactivity-related deaths worldwide. Understanding the mechanistic predictors of sedentary behaviors will improve future intervention development and precision medicine approaches. It has been posited that humans have an innate attraction towards effort minimization and that inhibitory control is required to overcome this prepotent disposition. Consequently, we hypothesized that individual differences in the functional connectivity of brain regions implicated in inhibitory control and physical effort decision making at the beginning of an exercise intervention in older adults would predict the change in time spent sedentary over the course of that intervention. In 143 healthy, low-active older adults participating in a 6-month aerobic exercise intervention (with three conditions: walking, dance, stretching), we aimed to use baseline neuroimaging (resting state functional connectivity of two a priori defined seed regions), and baseline accelerometer measures of time spent sedentary to predict future pre-post changes in objectively measured time spent sedentary in daily life over the 6-month intervention. Our results demonstrated that functional connectivity between (1) the anterior cingulate cortex and the supplementary motor area and (2) the right anterior insula and the left temporoparietal/temporooccipital junction, predicted changes in time spent sedentary in the walking group. Functional connectivity of these brain regions did not predict changes in time spent sedentary in the dance nor stretch and tone conditions, but baseline time spent sedentary was predictive in these conditions. Our results add important knowledge toward understanding mechanistic associations underlying complex out-of-session sedentary behaviors within a walking intervention setting in older adults.
The association of socio-economic and psychological factors with limitations in day-to-day activity over 7 years in newly diagnosed osteoarthritis patients
Authors: Kouraki Afroditi , Bast Tobias , Ferguson Eamonn , Valdes Ana M. 
Published: January 2022

AbstractPrevious research has established links between chronic pain and impaired cognitive ability, as well as between chronic pain and anxiety, in osteoarthritis. Furthermore, there is evidence linking risk of osteoarthritis to lower educational attainment. However, the inter-play of these factors with key social factors (e.g., social deprivation) at the early stages of osteoarthritis are not understood. Here, we used data from waves 4, 5, 6 and 7 of the Survey of Health, Ageing and Retirement in Europe (SHARE) (n = 971) and selected a subsample of respondents who initially did not report a diagnosis of osteoarthritis until wave 6. We used path models to test how social deprivation, education and anxiety, before diagnosis (waves 4 and 5), affect the relationship between cognitive ability, pain and limitations in activities of daily living following diagnosis (waves 6 and 7). We show that high social deprivation before diagnosis predicts greater limitations in activities of daily living after diagnosis, with this effect partly mediated by impaired cognitive ability. We also find that higher educational attainment before diagnosis may protect against limitations in activities of daily living after diagnosis via better cognitive ability and lower anxiety. Therefore, improving cognitive ability and managing anxiety may mitigate the associations of social deprivation and low educational attainment with limitations in activities of daily living.
Quantifying protein abundance on single cells using split-pool sequencing on DNA-barcoded antibodies for diagnostic applications
Authors: Sheng Jenny , Hod Eldad A. , Vlad George , Chavez Alejandro 
Published: January 2022

AbstractProteins play critical roles across all facets of biology, with their abundance frequently used as markers of cell identity and state. The most popular method for detecting proteins on single cells, flow cytometry, is limited by considerations of fluorescent spectral overlap. While mass cytometry (CyTOF) allows for the detection of upwards of 40 epitopes simultaneously, it requires local access to specialized instrumentation not commonly accessible to many laboratories. To overcome these limitations, we independently developed a method to quantify multiple protein targets on single cells without the need for specialty equipment other than access to widely available next generation sequencing (NGS) services. We demonstrate that this combinatorial indexing method compares favorably to traditional flow-cytometry, and allows over two dozen target proteins to be assayed at a time on single cells. To showcase the potential of the technique, we analyzed peripheral blood and bone marrow aspirates from human clinical samples, and identified pathogenic cellular subsets with high fidelity. The ease of use of this technique makes it a promising technology for high-throughput proteomics and for interrogating complex samples such as those from patients with leukemia.
High-throughput identification of genes influencing the competitive ability to obtain nutrients and performance of biocontrol in Pseudomonas putida JBC17
Authors: Dutta Swarnalee , Lee Yong Hoon 
Published: January 2022

AbstractElucidating underlying mechanisms of biocontrol agents (BCAs) could aid in selecting potent BCAs and increasing their biocontrol efficacy. Nutrient competition is an important biocontrol mechanism; however, essential nutrient sources, and contributing genes for nutrient competition still remain to be explored. Pseudomonas putida JBC17 (JBC17WT) suppressed green mold in satsuma mandarins by inhibiting conidial germination of Penicillium digitatum via nutrient competition. To analyze genes essential for biocontrol performance of JBC17WT, we generated a transposon (Tn)-mediated mutant library and selected mutants with the ability to suppress conidial germination. Several mutants in the genes of flagella-formation, including fliR, fliH, and flgG, increased biocontrol performance and enhanced inhibition of conidial germination. They lost swimming motility, exhibited increased growth and rapid carbon and nitrogen utilization than the wild type under nutrient-poor conditions. The nutrient competition assay using polytetrafluoroethylene cylinders revealed that conidial germination was inhibited by nutrient absorption under nutrient-poor conditions. In addition, genes, including amidohydrolase (ytcJ), tonB-dependent receptor (cirA), argininosuccinate synthase (argG), D-3-phosphoglycerate dehydrogenase (serA), and chaperone protein (dnaJ), were involved in the inhibition of conidial germination. The results of this study indicate that rapid and continuous absorption of nutrients by JBC17WT restrict nutrient availability for conidial germination on nutrient-limited fruit surfaces, thereby decreasing the chances of fungal spores infecting fruits. The high-throughput analysis of Tn mutants of this study highlighted the importance of nutrient competition and the genes that influence biocontrol ability, which contributes to the development of biocontrol applications.
A biogeographical study of red listed lichen species at temporal and spatial scales within protected and non-protected areas
Authors: Vicol Ioana , Mihăilescu Simona 
Published: January 2022

AbstractThe present study is focused on the temporal and spatial distribution of red listed lichen (RLL) species identified in both non-protected areas (NPAs) and protected areas (PAs) in Romania. This study revealed different scenarios of RLL based on two major patterns: (1) the fate of RLL before and after their designation in the red list in Romania and (2) the fate of RLL before and after the designation of PAs in Romania. Generally, the occurrences of RLL were well represented in time and space in both NPAs and PAs through geomorphological and biogeographical units. In particular, the occurrences of RLL were well represented, especially in hilly areas within PAs before and after their official designation, and this was an important aspect over a long period of time. Although NPAs were not less important regarding the occurrences of RLL species, it was observed that they followed the same pattern as PAs, namely, they were well represented in hilly areas and over a long period of time. The bioregions were significant for RLL species in both NPAs (continental and stepic) and PAs (continental, panonic, and stepic). As a significant finding of this study, NPAs and PAs should be subjected to an adequate conservation regime due to their biotical traditional heritage.
Effects of porous tantalum on periprosthetic bone remodeling around metaphyseal filling femoral stem: a multicenter, prospective, randomized controlled study
Authors: Motomura Goro , Mashima Naohiko , Imai Hiroshi , Sudo Akihiro , Hasegawa Masahiro , Yamada Harumoto , Morita Mitsuhiro , Mitsugi Naoto , Nakanishi Ryosuke , Nakashima Yasuharu 
Published: January 2022

AbstractPeriprosthetic bone loss due to adaptive bone remodeling is an important unresolved issue in cementless total hip arthroplasty (THA). The use of porous tantalum on the proximal surface of the femoral stem is expected to decrease postoperative bone loss around the prosthesis through early fixation. We conducted a multicenter randomized controlled study to determine if porous tantalum could reduce periprosthetic bone loss after THA. From October 2012 to September 2014, 118 patients (mean age, 61.5 years; 107 females and 11 males) were prospectively enrolled and were randomly allocated at a ratio of 1:1 to either a metaphyseal filling stem with a proximal porous tantalum coating (Trabecular Metal) or a conventional metaphyseal filling stem with fiber mesh coating (VerSys). Patients underwent dual-energy x-ray absorptiometry scans within 1 week after surgery (baseline) and at 6, 12, and 24 months after surgery to assess periprosthetic bone mineral density (BMD) in the 7 Gruen zones. In addition, the Japanese Orthopaedic Association hip score was assessed before surgery and at 6, 12, and 24 months after surgery. In the proximal periprosthetic region (zones 1 and 7), the Trabecular Metal group had significantly smaller reductions in BMD than the VerSys group throughout the study period. In the VerSys group, significant reductions in BMD compared to baseline were seen at each measurement point in all regions, except in zone 6 at 24 months. In the Trabecular Metal group, no significant reductions in BMD relative to baseline were seen in zones 1, 5, or 6 throughout the study period. Both groups demonstrated similar improvement in Japanese Orthopaedic Association hip scores over the study period. This study demonstrated that a proximally coated stem with porous tantalum has superior results over a conventional stem with titanium fiber mesh in terms of periprosthetic bone remodeling.
Plasmonic meniscus lenses
Authors: Riley Joseph Arnold , Healy Noel , Pacheco-Peña Victor 
Published: January 2022

AbstractControlling and manipulating the propagation of surface plasmons has become a field of intense research given their potential in a wide range of applications, such as plasmonic circuits, optical trapping, sensors, and lensing. In this communication, we exploit classical optics techniques to design and evaluate the performance of plasmonic lenses with meniscus-like geometries. To do this, we use an adapted lens maker equation that incorporates the effective medium concepts of surface plasmons polaritons travelling in dielectric-metal and dielectric-dielectric-metal configurations. The design process for such plasmonic meniscus lenses is detailed and two different plasmonic focusing structures are evaluated: a plasmonic lens with a quasi-planar output surface and a plasmonic meniscus lens having a convex-concave input–output surface, respectively. The structures are designed to have an effective focal length of 2λ0 at the visible wavelength of 633 nm. A performance comparison of the two plasmonic lenses is shown, demonstrating improvements to the power enhancement, with a 22% and 16.5% increase when using 2D (ideal) or 3D (realistic plasmonic) meniscus designs, respectively, compared to the power enhancement obtained with convex-planar lenses. It is also shown that the depth of focus of the focal spot presents a 19.8% decrease when using meniscus lenses in 2D and a 34.3% decrease when using the proposed 3D plasmonic meniscus designs. The broadband response of a plasmonic meniscus lens (550–750 nm wavelength range) is also studied along with the influence of potential fabrication errors on the generated effective focal length. The proposed plasmonic lenses could be exploited as alternative focusing devices for surface plasmons polaritons in applications such as sensing.
The optoelectronic properties improvement of double perovskites Cs2SnI6 by anionic doping (F−)
Authors: Wu Junsheng , Zhao Zhuo , Zhou Yanwen 
Published: January 2022

AbstractTin-based perovskite material is the best choice to replace heavy metal element lead during the last several years. Cs2SnI6 with Sn4+ is a fascinating optoelectronic material, which is a more air-stable composite cesium tin halide peroxide variant from CsSnI3. However, the optoelectronic performance between N and P type of Cs2SnI6 varies considerably. Herein, we synthesized uniform Cs2SnI6 by modified two-step method, which thermal evaporated CsI firstly, and followed annealing in the SnI4 and I2 vapor at 150 °C resulted in uniform Cs2SnI6 films. SnF4 is used as a dopant source to improve the optoelectronic properties of Cs2SnI6 films. Results indicate that good crystallinity was obtained for all films and the doped films underwent a crystalline plane meritocracy transition. The doped films had a flat, non-porous morphology with large grains. The high transmittance of the doped films in the infrared region led to the avoidance of self-generated thermal decomposition. With the help of F−, the films became more conductive and had higher carrier mobility. DFT calculations showed that doping with F reduced the surface energy of (004), resulted in a preferred orientation transition in the crystal of Cs2SnI6. Fluorine doped double layer perovskite materials would have a broader application prospect.
CCN2-induced lymphangiogenesis is mediated by the integrin αvβ5–ERK pathway and regulated by DUSP6
Authors: Hashiguchi Shiho , Tanaka Tomoko , Mano Ryosuke , Kondo Seiji , Kodama Shohta 
Published: January 2022

AbstractLymphangiogenesis is essential for the development of the lymphatic system and is important for physiological processes such as homeostasis, metabolism and immunity. Cellular communication network factor 2 (CCN2, also known as CTGF), is a modular and matricellular protein and a well-known angiogenic factor in physiological and pathological angiogenesis. However, its roles in lymphangiogenesis and intracellular signaling in lymphatic endothelial cells (LECs) remain unclear. Here, we investigated the effects of CCN2 on lymphangiogenesis. In in vivo Matrigel plug assays, exogenous CCN2 increased the number of Podoplanin-positive vessels. Subsequently, we found that CCN2 induced phosphorylation of ERK in primary cultured LECs, which was almost completely inhibited by the blockade of integrin αvβ5 and partially decreased by the blockade of integrin αvβ3. CCN2 promoted direct binding of ERK to dual-specific phosphatase 6 (DUSP6), which regulated the activation of excess ERK by dephosphorylating ERK. In vitro, CCN2 promoted tube formation in LECs, while suppression of Dusp6 further increased tube formation. In vivo, immunohistochemistry also detected ERK phosphorylation and DUSP6 expression in Podoplanin-positive cells on CCN2-supplemented Matrigel. These results indicated that CCN2 promotes lymphangiogenesis by enhancing integrin αvβ5-mediated phosphorylation of ERK and demonstrated that DUSP6 is a negative regulator of excessive lymphangiogenesis by CCN2.
Genome-wide perturbations of Alu expression and Alu-associated post-transcriptional regulations distinguish oligodendroglioma from other gliomas
Authors: Hwang Taeyoung , Kim Sojin , Chowdhury Tamrin , Yu Hyeon Jong , Kim Kyung-Min , Kang Ho , Won Jae-Kyung , Park Sung-Hye , Shin Joo Heon , Park Chul-Kee 
Published: January 2022

AbstractAlu is a primate-specific repeat element in the human genome and has been increasingly appreciated as a regulatory element in many biological processes. But the appreciation of Alu has been limited in tumorigenesis, especially for brain tumor. To investigate the relevance of Alu to the gliomagenesis, we studied Alu element-associated post-transcriptional processes and the RNA expression of the element by performing RNA-seq for a total of 41 pairs of neurotypical and diverse glioma brain tissues. We find that A-to-I editing and circular RNA levels, as well as Alu RNA expression, are decreased overall in gliomas, compared to normal tissue. Interestingly, grade 2 oligodendrogliomas are least affected in A-to-I editing and circular RNA levels among gliomas, whereas they have a higher proportion of down-regulated Alu subfamilies, compared to the other gliomas. These findings collectively imply a unique pattern of Alu-associated transcriptomes in grade 2 oligodendroglioma, providing an insight to gliomagenesis from the perspective of an evolutionary genetic element.
Construction of Li3PO4 nanoshells for the improved electrochemical performance of a Ni-rich cathode material
Authors: Tao Xian-Sen , Sun Yong-Gang , Xu Yan-Song , Liu Yuan , Luo Jin-Min , Cao An-Min 
Published: January 2022

A Li3PO4 nanocoating was successfully constructed via controlling the reaction between a nickel-rich cathode material and a preformed phosphorus-containing polymeric nanoshell, which contributes to much-improved electrochemical performance.
Bis(2-methoxyethyl)ether promoted intramolecular acceptorless dehydrogenative coupling to construct structurally diverse quinazolinones by molecular oxygen
Authors: Zhao Rongrong , Wen Simiaomiao , Fu Hao , Liu Mengna , Liu Qixing , Zhou Haifeng 
Published: January 2022

A simple, efficient and clean intramolecular oxidative dehydrogenative coupling for the synthesis of dihydroisoquinolino[2,1-a]quinazolinones, 2-aryl quinazolinones, and analogues promoted by bis(2-methoxyethyl)ether/O2 has been achieved.