bluuebunny/crossref_metadata_2025_split huggingface dataset:
Immunohistochemical study of uveal melanoma and its cellular microenvironment
Authors: Saakyan S. V. , Katargina L. A. , Myakoshina E. B. , Zakharova G. P. , Khoroshilova–Maslova I. P. , Maibogin A. M. 
Published: June 2022

Introduction. Uveal melanoma pathogenesis is determined by a number of factors, including the tumor molecular genetics, the organism’s immune response, and other ones. One of the approaches to studying the peculiarities of pathogenesis of this cancer is to determine the local subpopulations of lymphocytes and macrophages in combination with the study of the proliferative activity of tumor cells.Objective – to study the immunohistochemical features of uveal melanoma and its cellular microenvironment.Materials and methods. 24 enucleated eyes with uveal melanoma (144 histological and 216 immunohistochemicalpreparations) without previous treatment were analyzed. Cells of the immune microenvironment were analyzed: lymphocyte subpopulations and CD 68+ and CD 163+ antigens expressed by macrophages in the melanoma stroma and 2–3 mm from it. The tumor cell proliferation index Ki-67 was diagnosed.Results. All tissue samples of uveal melanoma revealed the presence of lymphocytes in the microenvironment of tumor cells. A large proportion of the studied subpopulations of lymphocytes were T-cytotoxic CD28+ lymphocytes (absolute content: 607.3 ± 431.2, relative: 18.84 % ± 12.12 %) (p = 0.018). A smaller proportion, but in equal proportions, were T-helpers CD4+, T-cytotoxic CD8+ and CD25+ lymphocytes (p = 0.6). The absolute number of natural killer cells subpopulation CD16+ was lower compared to CD56+ (p = 0.05). However, an almost equal relative content of the studied subpopulations was noted (p = 0.9). Histological examination revealed the presence of uveal melanoma macrophages in the microenvironment of the tissue. The immunohistochemical study of CD68+ and CD163+ antigens expressed by anti-inflammatory and pro-tumor macrophages showed that their absolute and relative content in the uveal melanoma tissue is almost the same with a slight predominance of CD163+ (p = 0.7). Immunohistochemical analysis showed that the nuclei of melanoma cells contain, on average, 575.2 ± 388.5 significant cells of the Ki-67 proliferation protein. This protein was found in 16.69 ± 10.88 % of tumor cells.Conclusion. Immunohistochemical study allows to identify subpopulations of lymphocytes infiltrating the tumor, to determine the subtypes of macrophages and to estimate the Ki-67 index of tumor cell proliferation. The data obtained will make it possible to further evaluate the significance of individual immune cells (in particular, T-cytotoxic CD28+ lymphocytes) in the pathogenesis of uveal melanoma in order to develop targeted effects, substantiate new immunotherapeutic approaches to the treatment of primary tumors and reprogramming altered immune cells.
Surgical embolectomy as a promising treatment of acute pulmonary embolism
Authors: Abdulyanov I. V. , Dzhordzhikiya R. K. , Fedorov S. A. , Atsel' Ye. A. , Sarychev A. A. 
Published: June 2022

Highlights. The article presents current literature data on the results of surgical treatment of acute pulmonary embolism.Abstract. The review article throws light on up to date approaches to the treatment of acute pulmonary embolism. The great variety of treatment methods and controversial results do not allow us to conclusively decide on which method to choose. Traditionally, pharmacological therapies have been favored over invasive methods because of the lower mortality rate. However, based on new studies, it can be established that interventional embolectomy is an effective option, showing good immediate and long-term results. Undoubtedly, additional studies are needed in order that surgical embolectomy developed from a rescue therapy of acute pulmonary embolism into a first-line or priority treatment.
Chronic and acute decompensated heart failure: topical issues
Authors: Okunev I. M. , Kochergina A. M. , Kashtalap V. V. 
Published: June 2022

Highlights. The article is a review of current literary data on the problem of acute decompensated heart failure. The review highlights the basic principles of the diagnosis and treatment, as well as the problems of their implementation into clinical practice.Abstract Acute decompensated heart failure (ADHF) is a life-threatening condition that requires an emergency hospitalization for intensive treatment. Moreover, it is the event that worsens the patient's further prognosis. Frequent rehospitalizations for decompensation of heart failure reduce life expectancy and quality, and are also a significant economic problem in practical health care. The increasing number of patients with heart failure leads to the growing number of patients seeking medical help for acute decompensated heart failure. More than half of the patients are re-hospitalized within a year for the same reason. The predicted increase in the prevalence of CHF worldwide makes the management of such patients a global medical and social problem. Patients delay, low compliance and insufficient ambulatory monitoring are the factors that need to be influenced in order to improve the prognosis. The article is a review of literary data on the epidemiology of ADHF, diagnosis, treatment and outpatient observation of patients with acute decompensated heart failure. The problems of compliance, the prospects for modern methods of remote monitoring and the possibilities of new drugs are discussed in the article.
Descriptive Comparison of Gastrointestinal Tract Histology of Various Avian Species based on their Natural Diet
Authors: Paramanandi Dini Agusti , Rahmawati Irhamna Putri , Wisnuwardana Guruh Jaya , Nugrahani Warih Pulung , Hardian Andreas Bandang 
Published: June 2022

Many animals species develop their gastrointestinal tube with special features to accommodate their natural diet to survive under adverse conditions including the nutrient absorption capability. Information related to the histologic description of various bird species' digestive organs based on their diet and its significance is yet limited. This study aimed to present a descriptive explanation of gastrointestinal organs of a changeable hawk-eagle (Nisaetus cirrhatu) and oriental honey buzzard (Pernis ptilorhynchus) as carnivorous, a southern cassowary (Casuarius casuarius) as an omnivorous, and a domestic chicken (Gallus gallus) as granivorous. In the current study, proventriculus (glandular stomach) and intestinal segments were microscopically examined and compared to understand the special histological features among avian species due to their important roles to digest the ingesta. The dissected specimens were preserved in 10% non-buffered formalin, then were processed through the common standard procedure of tissue processing and eventually stained with haematoxylin-eosin. Microscopic observation showed variation in shape and size of proventricular glandular architecture among raptors. The intestine muscular layer of the cassowary also showed distinct thickness among birds. These results of the study preliminary proved that variation in diet might affect the histologic features of avian gastrointestinal tracts.
Cytomorphological pattern of breast lesions diagnosed on fine-needle aspiration cytology in a district hospital in Kashmir valley
Authors: Qadri Shaika , Khan Subuh Parvez , Farooq Summyia , Bhat Abdul Rouf 
Published: June 2022

Background: Breast lump is the most common presentation of the breast disease. Fine needle aspiration cytology (FNAC) is a simple, rapid and safe, method to diagnose the breast lesions. The objective of this study was to determine the cytomorphological patterns of various breast lesions diagnosed on FNAC. Methods: This study was conducted on 280 patients presenting with breast lump over a period of 3 years.Results: The age range of these patients was from 11-80 years. Female patients were more than male patients. Left breast involvement was more common than the right breast. The cytological diagnosis included benign breast disease (C2-88%), atypical/probably benign (C3-1%), suspicious for malignancy (C4-3%), malignant (C5-8%). Fibroadenoma and invasive ductal carcinoma were most common among benign and malignant lesions respectively.Conclusions: The primary goal of aspiration cytology is to separate malignant lesions from benign ones and it also makes an important tool in guiding further management of a case. So, it is concluded that FNAC should be used as a routine diagnostic procedure due to its cost effectiveness and quick results, thus maximizing the availability of effective health care to patients with breast lesions.
ANALISIS IMPLEMENTASI PROGRAM LOMBA KAMPUNG SURABAYA SMART CITY DALAM MENUNJANG PENATAAN LINGKUNGAN YANG BAIK DI KOTA SURABAYA
Authors: Irianto Heru , Prasetijowati Tri , Esferansa Bela 
Published: June 2022

Implementasi program lomba kampung Surabaya Smart City dalam menunjang penataan lingkungan yang baik di Kota Surabaya telah dilaksanakan Dinas Kebersihan dan Ruang Terbuka Hijau Kota Surabaya mulai tahun 2019, pelaksanaannya sudah berjalan dengan baik sampai saat ini dimana program tersebut dapat meningkatkan kualitas hidup masyarakat, pemukiman menjadi indah dan bersih, serta warga menjadi kompak. Penelitian ini merupakan penelitian kualitatif deskriptif dengan teknik purposive sampling yang dilakukan di Dinas Kebersihan dan Ruang Terbuka Hijau Kota Surabaya serta di kediaman perwakilan peserta yaitu Ketua RW 04 ibu Yuli dan Ketua RW 01 Ibu Sri. Teknik pengumpulan data yang digunakan berupa wawancara dan dokumentasi. Analisis data yang dilakukan dengan reduksi data, penyajian data dan penarikan kesimpulan. Hasil penelitian menunjukkan bahwa implementasi program lomba kampung Surabaya Smart City pada implementasi kebijakan model George Edward III yang digunakan dalam penelitian ini ditinjau dari beberapa variabel yaitu 1. Komunikasi sudah dijalankan dengan baik dengan menyampaikan informasi melalui media massa serta dibantu team fasilitator lingkungan dan fasilitator kelurahan, 2. Disposisi dari pelaksana yang jujur, ramah dan saling mendukung dalam bekerja sama sehingga implementasi program berjalan dengan efektif sesuai yang diharapkan, dan 3. Struktur birokrasi dengan menentukan SOP (Standart Operasional Procedure) agar program terkoordinir dengan baik. Faktor penghambatnya adalah sumber daya manusia yaitu peserta yang kurang akrab dengan teknologi dan kendala dari sinyal internet, upaya dalam mengatasi hambatan adalah tetap mengadakan sosialisasi dan bekerjasama dengan instansi lain.Kata Kunci : Implementasi, Lomba Surabaya Smart City, Penataan Lingkungan
IMPLEMENTASI E KINERJA PADA DINAS PENANAMAN MODAL DAN PELAYANAN TERPADU SATU PINTU KABUPATEN BALANGAN
Authors: Rahmaniah Rahmaniah 
Published: June 2022

Pelaksanaan E Kinerja pada Dinas Penanaman Modal dan Pelayanan Terpad Satu Pintu Kabupaten Balangan sesuai dengan amanat Undang-undang Nomor 15 Tahun 20014 tentang Apartur Sipil Negara Pasal 80 ayat 3 Tunjangan kinerja dibayarkan sesuai dengan penacapaian kinerja. Penelitian ini menggunakan pendekatan deskriftif kualitatif, dengan teknik analisis data yaitu : 1. Pengumpulan data, 2. Reduksi data, 3. Data display, 4. Conclusion darawing/verification.Informan penelitian tediri dari Pegawai Dinas Penananamn Modal Dan Pelayanan Terpadu Satu Pintu Kabupaten Balangan. Hasil penelitaian ini menggambarkan bagaimana implementasi E kinerja, dan faktor pendukung serta penghambat dalam pelaksanaannya pada Dinas Penanaman Modal dan Pelayanan Terpadu Satu Pintu Kabupaten Balangan,Sistem E Kinerja dilaksanakan dan dimulai tahap uji coba mulai bulan Januari sampai dengan bulan Maret 2020 berapapun nilai E kinerja yang diperoleh Pegawai Negeri Sipil Tetap Memperoleh Tambahan Penghasilan Pegawai 100%, setalah melalui tahap uji coba dan dirasa Pegawai Negeri Sipil sudah terbiasa mulai bulan April 2020 sudah dilaksanakan secara efektif dan sesuai dengan penilaian yang diperoleh untuk mendapatkan Tambahan Penghasilan Pegawai (TPP), Diterapkannya E kinerja sesuai ketentuan dan peraturan yang berlaku dan manfaatnya : 1. Alat untuk mengontrol Kehadiran Pegawai, 2. Meningkatkan Kinerja Pegawai, 3. Memudahkan manajemen birokrasi, 4. Sebagai indikator pemberian Tambahan Penghasilan Pegawai (TPP). Kesimpulan dari penelitian ini adalah dengan adanya Implemetasi E kinerja pada Dinas Penanaman Modal dan Pelayanan Terpadu Satu Pintu dimulai dengan tahapan Penginputan data kinerja pegawai, Penyusunan SKP, dan diperolehlah Equal Pay For Equal Work (TPP) berpengaruh positif terhadap kinerja yang dihasilkan oleh pegawai, karena kinerja positif sehingga meningkatkan pencapaian Visi dan Misi SKPD, yang pada akhirnya memaksimalkan tujuan RPJMD Kabupaten Balangan, Faktor Pendukung dalam Implementasi E Kinerja Pegawai : Motivasi untuk medapatkan reward, Era digital 4.0, Sarana dan prasarana berupa tersedianya perangkat komputer dan penggunaan media android yang dimiliki oleh para pegawai. Faktor penghambat dalam Implementasi E Kinerja : Koneksi jaringan internet, apaila terjadi pemedaman listrik maka internet tidak berfungsi, Kedisiplinan pengisian E – Kinerja, Subyektifitas penilaian atasan atau pimpinan.Kata Kunci : Implementasi, E Kinerja.
Paralic sedimentology of the Mussentuchit Member coastal plain, Cedar Mountain Formation, central Utah, U.S.A.
Authors: Tucker Ryan T. , Suarez Celina A. , Makovicky Peter J. , Zanno Lindsay E. 
Published: June 2022

ABSTRACTAlthough intensified work on the volcaniclastic-rich sediments of the fossil-bearing Mussentuchit Member (uppermost Cedar Mountain Formation, Utah) has provided a refined chronostratigraphic framework, paleoenvironmental interpretations remain cryptic. To resolve this, we performed facies analysis and architectural reconstruction on exposed Mussentuchit Member outcrops south of Emery, central Utah, USA. Contrary to previous interpretations (fluvial, lacustrine), we identified a broad suite of facies that indicate that deposition occurred on the landward part of a paralic depocenter, influenced by both distal alluvial and proximal coastal systems. We conclude that the Mussentuchit Member was a sink for suspension-settling fines with most undergoing pedogenic alteration, analogous to the modern coastal plain of French Guiana (Wang et al. 2002; Anthony et al. 2010, 2014). However, this landward paralic depocenter was not uniform through time. Sedimentological evidence indicates landscape modification was ongoing, influenced by an altered base-level (high groundwater table, long residency of water in sediments, shifts in paleosol types, heavier to lighter δ18O, and distinct shifts in relative humidity (ε); common in coastal settings). If the above data is coupled with recent age data, we interpret that the Mussentuchit Member correlates to the S.B. 4 Greenhorn Regression (Thatcher Limestone) of the adjacent Western Interior Seaway to the east. As a landward paralic depocenter, the Mussentuchit would have been sensitive to base-level conditions in response to ongoing tectonic processes pushing the foredeep east, and lower paleo-CO2 levels coupled with a minor global sea-level fall (brief glacial phase) just before to the Cenomanian–Turonian Thermal Maximum. Altogether, our results not only strengthen linkages in the central Western Interior Seaway, but simultaneously results in novel linkages to near-coeval paralic depocenters across mid-Cenomanian North America.
Joint Trajectory and CoMP Clustering Optimization in UAV-Assisted Cellular Systems: A Coalition Formation Game Approach
Authors: Abdelhakam Mostafa , Elmesalawy Mahmoud , Ibrahim Ibrahim , Sayed Samir 
Published: June 2022

Abstract
In this paper, the flexibility of unmanned aerial vehicles (UAVs), as well as the benefits of coordinated multi-point (CoMP) transmission, are utilized for mitigating the interference in cellular networks. Specifically, the joint problem of CoMP clusters and UAVs’ trajectories is addressed for downlink transmission in a UAV-assisted cellular system. The problem is presented as a non-convex optimization problem that aims to maximize the sum rate of the ground users by taking into account the clustering, UAV mobility and backhaul capacity constraints. Since the formulated problem is known to be NP-hard, we partition it into two sub-problems. Particularly, by using coalitional game theory, the CoMP clusters are obtained with a given UAVs’ trajectories. Then, UAVs’ trajectories are optimized with given CoMP clusters using successive convex approximation (SCA) technique. Based on the block coordinate descent (BCD) method, the two sub-problems are solved alternatively until convergence. Numerical results are conducted and demonstrate the effectiveness of the proposed algorithm.
An empirical investigation of the relationship between nuclear energy and environmental pollution in France: fresh evidence using asymmetric cointegration
Authors: Omri Emna , Saadaoui Haifa 
Published: June 2022

Abstract
The intention behind the current analysis is to join the debate over the main factors to consider in the global fight against climate change. Thereby, we used the non-linear Autoregressive Distributed Lag (NARDL) cointegration approach to test the impacts of nuclear energy, fossil fuels, trade openness and economic growth on carbon emissions in France. In addition, we test the validity of the Environmental Kuznets Curve (EKC) assumption. Our results stipulate that nuclear power lessens CO2 emissions in France. However, fossil fuels and trade openness enhance these emissions. On the other hand, the current analysis confirms the existence of an inverted U-shaped curve relying income with CO2 emissions. Therefore, the EKC hypothesis is supported in our case. Indeed, by calculating the turning point, we can further extract the turning year which corresponds to the year 2012.
Chemical physically unclonable functions for anti- counterfeiting tracers combined by cloud authentication
Authors: Fukuoka Takao , Katsurada Kayoko , Namura Kyoko , Suzuki Motofumi , Yamaguchi Akinobu 
Published: June 2022

Abstract
Physically unclonable functions (PUFs) are often used as robust anti-counterfeiting labels because they have fingerprints of device element characteristics due to the variations and fluctuations in the dimensional accuracy during manufacturing. An individual fingerprint can become a powerful tool against counterfeiting. Nanobeacons (NBs) with embedded Raman reporters show strong intensity enhancement, stealth performance, and long-term chemical stability. In this study, we demonstrated authenticity judgment using a chemical PUFs based on the NBs, mobile Raman detector, and a smartphone. It can be applied in the form of an ink, and it can be seen that the NBs are randomly distributed in space. By changing the embedded reporter molecule, it was shown that the NBs tracking, and imaging are possible with multicolor coating. Authentication experiments verified the security of the chemical PUFs tracers, robustness, convenience and ease of use. The chemical PUFs tracers and authenticity system could become a state-of-the-art platform to realize unbreakable anti-counterfeiting.
What matters in development and sustainment of community dementia friendly initiatives and why? A realist multiple case study
Authors: Thijssen Marjolein , Kuijer-Siebelink Wietske , Lexis Monique A.S. , Sanden Maria W.G. Nijhuis-van der , Daniels Ramon , Graff Maud 
Published: June 2022

Abstract
Background
Dementia friendly communities (DFCs) are seen as key to participation of people with dementia and carers. Dementia-friendly initiatives (DFI) are important building blocks for the growth of DFCs. Therefore, it is essential to understand how DFIs are developed and sustained to secure the growth of DFCs. This study identifies contextual factors and mechanisms that influence the development and sustainment of Dutch DFIs. It also explains how these contextual factors and mechanisms are interrelated and the outcomes to which they lead.
Methods
Mixed methods, namely interviews, observations, documentation and focus groups, were used for this realist multiple case study. Participants were professionals (n = 46), volunteers (n = 20), people with dementia (n = 1) and carers (n = 2) who were involved in development and sustainment of DFIs in four Dutch DFCs.
Results
This study revealed three middle-range program theories as final outcomes: development of a support base, collaboration, and participation in DFIs by people with dementia and carers. These theories address institutional, organisational, interpersonal and individual levels in the community that are essential in development and sustainment of DFIs.
Conclusions
The development and sustainment of DFIs requires the development of a support base, collaboration, and participation in DFIs by people with dementia and their carers.
Autologous hematopoietic stem cell transplantation activity for lymphoma and multiple myeloma in China
Authors: Zhu Jun , Liu Weiping , Ji Jie , Zou Dehui , Cao Yang , Xu Yajing , zhou jian , Gao Sujun , Wang Fengr-Rong , CHEN WEN , Du Juan , Zhou Hui , Zhou Fuling , Shi Jimin , Zhang Xi , Yang Jianmin , Jing Hongmei , Jiang Zhongxing , Liu Hui , Li Caixia , Peng Hongling , Jiang Songfu , Wei Xiaolei , He Pengcheng , Liu Yao , Yang Haiyan , Li Zeng-jun , Huang xiaobing , Liu Lin , Shen Lijing , Liu Chuanfang , Song Yuqin , Qiu Lugui , Wang Xiaopei , Ma Jun 
Published: June 2022

Abstract
Little is known regarding the utilization rate of autologous hematopoietic stem cell transplantation (AHSCT) for lymphoma and multiple myeloma (MM) in the mainland of China. In 2019, the autologous stem cell transplantation group of Chinese Society of Clinical Oncology reported 4556 first transplantations with a utilization rate of 3.8% for lymphoma and MM. The AHSCT utilization rates were 2.4% for lymphoma and 11.3% for MM. For lymphoma, the transplantation utilization rate was over 5.0% in the age group of 20–50 years with a peak of 6.5% in the age group of 40–44 years; for MM, the rate was over 10.0% in the age group of 35–65 with a peak of 33.8% in the age group of 45–49 years. The eastern region had higher transplantation utilization rate than central and western regions (4.6% vs. 3.0% vs. 3.3%). There was a wide gap in AHSCT utilization rates between the developed and developing provinces. Beijing had the highest transplantation utilization rate for both lymphoma and MM. This study provided a comprehensive evaluation of AHSCT utilization for lymphoma and MM in China, which will be useful for policy-making with respect to healthcare resource allocation and disease control strategies.