bluuebunny/crossref_metadata_2025_split huggingface dataset:
A review of menopause nomenclature
Authors: Ambikairajah Ananthan , Walsh Erin , Cherbuin Nicolas 
Published: January 2022

AbstractMenopause nomenclature varies in the scholarly literature making synthesis and interpretation of research findings difficult. Therefore, the present study aimed to review and discuss critical developments in menopause nomenclature; determine the level of heterogeneity amongst menopause definitions and compare them with the Stages of Reproductive Aging Workshop criteria. Definitions/criteria used to characterise premenopausal and postmenopausal status were extracted from 210 studies and 128 of these studies were included in the final analyses. The main findings were that 39.84% of included studies were consistent with STRAW classification of premenopause, whereas 70.31% were consistent with STRAW classification of postmenopause. Surprisingly, major inconsistencies relating to premenopause definition were due to a total lack of reporting of any definitions/criteria for premenopause (39.84% of studies). In contrast, only 20.31% did not report definitions/criteria for postmenopause. The present findings indicate that there is a significant amount of heterogeneity associated with the definition of premenopause, compared with postmenopause. We propose three key suggestions/recommendations, which can be distilled from these findings. Firstly, premenopause should be transparently operationalised and reported. Secondly, as a minimum requirement, regular menstruation should be defined as the number of menstrual cycles in a period of at least 3 months. Finally, the utility of introducing normative age-ranges as supplementary criterion for defining stages of reproductive ageing should be considered. The use of consistent terminology in research will enhance our capacity to compare results from different studies and more effectively investigate issues related to women’s health and ageing.
Utilization of long acting and permanent contraceptive methods and associated factor among women of reproductive age in west Guji zone, Southwest Ethiopia
Authors: Zeleke Eden Dagnachew , Assefa Dawit Getachew , Woldesenbet Tigist Tekle , Gido Rediet , Mengistu Nebiyu , Molla Wondwosen 
Published: January 2022

Abstract
Background
Increasing access to family planning helps to ensure the reproductive right, decrease unintended pregnancy, improve the health and nutritional status of children, reduction of maternal mortality, and enhance longer birth spacing. However, there is continually low utilization of long acting and permanent contraceptive methods among low and middle-income countries. This study aimed to assess the utilization of long acting and permanent contraceptive methods (LAPMs) and associated factors among women of reproductive age in the West Guji Zone, Ethiopia.

Methods
An institution-based cross-sectional study was carried out among 507 women of reproductive age in the West Guji Zone, Southwest Ethiopia from April 15 to May 15, 2018. Data were collected by a structured, pretested, and interview-based questionnaire with open ended and closed ended questionnaire, then entered, and analyzed by SPSS Version 20. Bivariable and multivariate logistic regression analyses were carried out. A 95% confidence interval (CI) AND P-value < 0.05 was considered to declare statistically significant variables.

Result
The current utilization of LAPMs at West Guji zone among the reproductive-aged group was found to be 51.1%. More than the median of participants had negative altitude (72.4%) and poor knowledge (57%) towards the LAPMs. Educational status of women, the number of alive children, acceptance of utilization of LAPMs, how treated by other staff, and waiting time during service delivery are significant determinant factors of LAPMs.

Conclusion
Overall, more than half of women had a negative attitude and poor knowledge of LAPMs. Educational status of women, the number of alive children, acceptance of utilization of LAPMs, how treated by other staff, and waiting time during service delivery were factors affecting utilization of LAPMs. Therefore, sustained, and appropriate information on LAPMs should be provided to raise knowledge and build the attitude of women and the community. Treating the clients with respect, reducing the waiting time, and collaborative work with health extension worker will enhance utilization of LAPMs.
Upregulation of nuclear factor E2-related factor 2 (Nrf2) represses the replication of herpes simplex virus type 1
Authors: Zhang Li , Wang Jiao , Wang Zhan , Li Ying , Wang Hui , Liu Hongtu 
Published: January 2022

AbstractBackgroundNuclear factor E2-related factor 2 (Nrf2) is an important transcription factor which plays a pivotal role in detoxifying reactive oxygen species (ROS) and has been more recently shown to regulate inflammatory and antiviral responses. However, the role of Nrf2 in Herpes Simplex Virus type 1 (HSV-1) infection is still unclear. In this study, the interaction between the Nrf2 and HSV-1 replication was investigated.MethodsThe levels of oxidative stress was monitored by using 8-hydroxy-2'-deoxyguanosine (8-OHdG) ELISA kits, and the dynamic changes of Nrf2-antioxidant response element (Nrf2-ARE) pathway were detected by Western Blot. The effect of Nrf2-ARE pathway on the regulation of HSV-1 proliferation was analyzed by Western Blot, Real-Time PCR and TCID50assay.ResultsHSV-1 infection induced oxidative stress. Nrf2 was activated, accompanied by the increase of its down-stream antioxidant enzyme heme oxygenase-1 (HO-1) and NAD(P)H quinone oxidoreductase 1 (NQO1) in the early stage of HSV-1 infection. The proliferation of HSV-1 was inhibited by overexpression of Nrf2 or treatment with its activator tert-Butylhydroquinone (tBHQ). On the contrary, silencing of Nrf2 promotes virus replication. HO-1 is involved in the regulation of IFN response, leading to efficient anti-HSV-1 effects.ConclusionOur observations indicate that the Nrf2-ARE pathway activates a passive defensive response in the early stage of HSV-1 infection. Targeting the Nrf2 pathway demonstrates the potential for combating HSV-1 infection.
Potential influences on optimizing long-term musculoskeletal health in children and adolescents with X-linked hypophosphatemia (XLH)
Authors: Glorieux Francis H. , Bonewald Lynda F. , Harvey Nicholas C. , van der Meulen Marjolein C. H. 
Published: January 2022

AbstractIn recent years, much progress has been made in understanding the mechanisms of bone growth and development over a lifespan, including the crosstalk between muscle and bone, to achieve optimal structure and function. While there have been significant advances in understanding how to help improve and maintain bone health in normal individuals, there is limited knowledge on whether these mechanisms apply or are compromised in pathological states. X-linked hypophosphatemia (XLH) (ORPHA:89936) is a rare, heritable, renal phosphate-wasting disorder. The resultant chronic hypophosphatemia leads to progressive deterioration in musculoskeletal function, including impaired growth, rickets, and limb deformities in children, as well as lifelong osteomalacia with reduced bone quality and impaired muscle structure and function. The clinical manifestations of the disease vary both in presentation and severity in affected individuals, and many of the consequences of childhood defects persist into adulthood, causing significant morbidity that impacts physical function and quality of life. Intervention to restore phosphate levels early in life during the critical stages of skeletal development in children with XLH could optimize growth and may prevent or reduce bone deformities in childhood. A healthier bone structure, together with improved muscle function, can lead to physical activity enhancing musculoskeletal health throughout life. In adults, continued management may help to maintain the positive effects acquired from childhood treatment, thereby slowing or halting disease progression. In this review, we summarize the opinions from members of a working group with expertise in pediatrics, epidemiology, and bone, joint and muscle biology, on potential outcomes for people with XLH, who have been optimally treated from an early age and continue treatment throughout life.
Developmental brain structural atypicalities in autism: a voxel-based morphometry analysis
Authors: Wang Hui , Ma Zeng-Hui , Xu Ling-Zi , Yang Liu , Ji Zhao-Zheng , Tang Xin-Zhou , Liu Jing-Ran , Li Xue , Cao Qing-Jiu , Liu Jing 
Published: January 2022

Abstract
Background
Structural magnetic resonance imaging (sMRI) studies have shown atypicalities in structural brain changes in individuals with autism spectrum disorder (ASD), while a noticeable discrepancy in their results indicates the necessity of conducting further researches.

Methods
The current study investigated the atypical structural brain features of autistic individuals who aged 6–30 years old. A total of 52 autistic individuals and 50 age-, gender-, and intelligence quotient (IQ)-matched typically developing (TD) individuals were included in this study, and were assigned into three based cohorts: childhood (6–12 years old), adolescence (13–18 years old), and adulthood (19–30 years old). Analyses of whole-brain volume and voxel-based morphometry (VBM) on the sMRI data were conducted.

Results
No significant difference was found in the volumes of whole-brain, gray matter, and white matter between the autism and TD groups in the three age-based cohorts. For VBM analyses, the volumes of gray matter in the right superior temporal gyrus and right inferior parietal lobule in the autism group (6–12 years old) were smaller than those in the TD group; the gray matter volume in the left inferior parietal lobule in the autism group (13–18 years old) was larger than that in the TD group; the gray matter volume in the right middle occipital gyrus in the autism group (19–30 years old) was larger than that in the TD group, and the gray matter volume in the left posterior cingulate gyrus in the autism group was smaller than that in the TD group.

Conclusion
Autistic individuals showed different atypical regional gray matter volumetric changes in childhood, adolescence, and adulthood compared to their TD peers, indicating that it is essential to consider developmental stages of the brain when exploring brain structural atypicalities in autism.
Study protocol for comparing Screening, Brief Intervention, and Referral to Treatment (SBIRT) to referral as usual for depression in African American churches
Authors: Hankerson Sidney H. , Shelton Rachel , Weissman Myrna , Wells Kenneth B. , Teresi Jeanne , Mallaiah Janhavi , Joshua Amita , Williams Olajide 
Published: January 2022

Abstract
Background
Depression is a leading cause of disability worldwide. African American adults, compared to White adults, are half as likely to be screened for depression in primary care settings. Disparities in depression screening contribute to poor clinical outcomes, as African Americans with depression are more disabled and sicker longer compared to Whites. African American churches are trusted settings that provide access to supports for depression. Indeed, in the first study of its kind, the investigators found that 20% of adults in African American churches screened positive for depression using the Patient Health Questionnaire-9 (PHQ-9). However, no subjects with a positive screen (PHQ-9 ≥ 10) accepted a treatment referral when offered by research personnel. Community Health Workers, who are trusted paraprofessionals from the target community, may bridge the gap between depression screening and treatment. The investigators have trained and certified 112 Community Health Workers from 45 African American churches in New York City to deliver an evidence-based intervention called Screening, Brief Intervention, and Referral to Treatment (SBIRT). Thus, the aim of the current study is to test the impact of Community Health Worker-delivered depression screening in Black churches on engagement with clinical services.

Methods
Using a hybrid type 1 effectiveness-implementation design, we propose a 2-arm, mixed-methods cluster randomized controlled trial. Church study sites will be randomized to either SBIRT (intervention arm) or referral as usual (usual care arm). This trial will be conducted with 600 church members across 30 churches (300 intervention; 300 usual care). Our primary outcome is treatment engagement, defined as attending a depression-related clinical visit. Secondary outcomes will be changes in Mental Health-Related Quality of Life and depressive symptoms at 3 and 6 months post-screening. Lastly, we will conduct a concurrent, mixed-methods (qualitative-quantitative) process evaluation to assess contextual facilitators and barriers of screening and referral.

Discussion
This is the first randomized trial of a church-placed, community health worker-delivered intervention for depression in African American populations. This study may provide a novel and effective approach to increasing depression identification and treatment linkage in economically disadvantaged populations with high depression rates.

Trial registration
ClinicalTrials.govNCT04524767. Registered on 21 August 2020.
Monitoring insecticide resistance of adult and larval Aedes aegypti (Diptera: Culicidae) in Phnom Penh, Cambodia
Authors: Boyer Sebastien , Maquart Pierre-Olivier , Chhuoy Kalyan , Suor Kimhuor , Chhum Moeun , Heng Kimly , Leng Sokkeang , Fontenille Didier , Marcombe Sebastien 
Published: January 2022

Abstract
Background
Dengue fever is a major public health concern in Cambodia, with thousands of cases every year in urban, suburban and rural areas of the country. The main vector of dengue fever in Cambodia is Aedes aegypti. The organophosphate larvicide temephos and adulticides belonging to the pyrethroid family have been widely used for decades by public health authorities to fight dengue vectors, but resistance of Ae. aegypti to these insecticides has been previously described for Cambodia.

Methods
In order to adapt the vector control strategy presently used in Cambodia, we tested 14 adulticides belonging to the carbamate, organochlorine, organophosphate, and pyrethroid insecticide families and three larvicides [temephos, spinosad and Bacillus thuringiensis ser. israelensis (Bti)] belonging to three different insecticide families (organophosphates, spinosyns and entomopathogenic bacteria). The standard procedures used here to test the adults and larvae of an Ae. aegypti population from Phnom Penh followed World Health Organization guidelines.

Results
For adults, high mortality rates were observed with carbamate, organophosphate and organochlorine (with the exception of dichlorodiphenyltrichloroethane) insecticides (i.e. between 87.6 and 100%), while low mortality rates were observed with all of the tested pyrethroid insecticides (i.e. between 1 and 35%). For larvae, no resistance against Bti was detected [resistance ratio (RR90 < 1.6)], but moderate resistance was observed for temephos and spinosad (RR90 < 5.6).

Conclusions
The results of this study indicate that (i) Bti should be considered a serious alternative to temephos for the control of Ae. aegypti larvae; and (ii) the carbamate adulticides propoxur and bendiocarb should be employed instead of the widely used pyrethroid insecticides for the control of adult Ae. aegypti on land under mosaic farming and crop rotation in Cambodia, as the insects were found to be resistant to the latter types of insecticide. Research focusing on insecticide resistance and innovative and effective vector control strategies should be undertaken as a public health priority in Cambodia.

Graphical abstract
Gene–gene interaction of AhRwith and within the Wntcascade affects susceptibility to lung cancer
Authors: Rosenberger Albert , Muttray Nils , Hung Rayjean J. , Christiani David C. , Caporaso Neil E. , Liu Geoffrey , Bojesen Stig E. , Le Marchand Loic , Albanes Demetrios , Aldrich Melinda C. , Tardon Adonina , Fernández-Tardón Guillermo , Rennert Gad , Field John K. , Davies Michael P. A. , Liloglou Triantafillos , Kiemeney Lambertus A. , Lazarus Philip , Wendel Bernadette , Haugen Aage , Zienolddiny Shanbeh , Lam Stephen , Schabath Matthew B. , Andrew Angeline S. , Duell Eric J. , Arnold Susanne M. , Goodman Gary E. , Chen Chu , Doherty Jennifer A. , Taylor Fiona , Cox Angela , Woll Penella J. , Risch Angela , Muley Thomas R. , Johansson Mikael , Brennan Paul , Landi Maria Teresa , Shete Sanjay S. , Amos Christopher I. , Bickeböller Heike ,   The INTEGRAL-ILCCO Consortium
Published: January 2022

AbstractBackgroundAberrantWntsignalling, regulating cell development and stemness, influences the development of many cancer types. The Aryl hydrocarbon receptor (AhR) mediates tumorigenesis of environmental pollutants. Complex interaction patterns of genes assigned toAhR/Wnt-signalling were recently associated with lung cancer susceptibility.AimTo assess the association and predictive ability ofAhR/Wnt-genes with lung cancer in cases and controls of European descent.MethodsOdds ratios (OR) were estimated for genomic variants assigned to the Wnt agonist and the antagonistic genesDKK2,DKK3,DKK4,FRZB,SFRP4andAxin2. Logistic regression models with variable selection were trained, validated and tested to predict lung cancer, at which other previously identified SNPs that have been robustly associated with lung cancer risk could also enter the model. Furthermore, decision trees were created to investigate variant × variant interaction. All analyses were performed for overall lung cancer and for subgroups.ResultsNo genome-wide significant association ofAhR/Wnt-genes with overall lung cancer was observed, but within the subgroups of ever smokers (e.g., maker rs2722278SFRP4; OR  = 1.20; 95% CI 1.13–1.27;p  = 5.6 × 10–10) and never smokers (e.g., maker rs1133683Axin2; OR  = 1.27; 95% CI 1.19–1.35;p  = 1.0 × 10–12). Although predictability is poor,AhR/Wnt-variantsare unexpectedly overrepresented in optimized prediction scores for overall lung cancer and for small cell lung cancer. Remarkably, the score for never-smokers contained solely twoAhR/Wnt-variants. The optimal decision tree for never smokers consists of 7AhR/Wnt-variantsand only two lung cancer variants.ConclusionsThe role of variants belonging toWnt/AhR-pathways in lung cancer susceptibility may be underrated in main-effects association analysis. Complex interaction patterns in individuals of European descent have moderate predictive capacity for lung cancer or subgroups thereof, especially in never smokers.
MATLAB codes for generating dispersion images for ground exploration using different multichannel analysis of surface wave transforms
Authors: Naskar Tarun , Kumar Jyant 
Published: January 2022

A set of codes has been developed in MATLAB for generating multimodal dispersion images by using three different transformation techniques. While performing the multichannel analysis of surface waves (MASW), the field data obtained by using multiple geophones, in the distance and time domain, become the required input data for these developed programs. The dispersion images have been evaluated by generating synthetic data and performing field tests using a 20 lb hammer at two different chosen sites with 48 geophones. The dispersion plots from the three different transformation techniques are found to match each other closely. In general, the circular frequency-phase velocity ([Formula: see text]- c) transform provides the best clarity. An increase in the spread length, however, without increasing the number of sensors, often leads to the appearance of aliased modes in the dispersion images.
Revisiting the flight dynamics of take-off of a butterfly: experiments and CFD simulations for a cabbage white butterfly
Authors: Suzuki Kosuke , Nakamura Masashi , Kouji Masaya , Yoshino Masato 
Published: January 2022

ABSTRACT
We conducted measurements of the taking-off motion of a butterfly (Pieris rapae) and numerical simulations using a computational model reflecting its motion. The computational butterfly model is composed of a thorax, an abdomen, and four wings (left and right wings with fore and hind parts), i.e. a six-link, rigid-body system. The present model is more sophisticated than any models that have ever been constructed in existing studies. In the butterfly model, the body trajectory and thoracic pitching angle can be calculated from the equations of motion, whereas the abdominal angle and wings’ joint angles are prescribed by the measured data. We calculated the flow field, aerodynamic force and torque generated by the butterfly model using the immersed boundary–lattice Boltzmann method. As a result, the butterfly generates the horizontal vortex ring and aerodynamic lift force during the downstroke, while it generates the vertical vortex ring and aerodynamic thrust force during the upstroke. The leg impulsion is essential in the upward motion of the taking-off butterfly rather than the aerodynamic lift force by the flapping wings. The inertial forces of the abdomen and wings are comparable in magnitude with the aerodynamic forces, but the net influence of the inertial forces on the position of the butterfly is not significant due to the offsetting of the body and wing inertia. The net aerodynamic and gravitational torques raise the thorax of the butterfly, and the net inertial torques suppress the rise of the thorax.
Vacuum-Freeze Drying Assist for the Fabrication of a Nickel-Aluminium Catalyst and Its Effects on the Structure-Reactivity in the Catalytic Dry Reforming of Methane
Authors: Cao Pengfei , Zhao Haitao , Adegbite Stephen , Lester Edward , Wu Tao 
Published: January 2022

Abstract
In this study, a co-precipitation coupled with vacuum-freeze drying (VFD) method was adopted to fabricate a highly mesoporous nickel-aluminium catalyst (VFD-cat). VFD-cat with uniform smaller pore size and a larger BET surface area were obtained than the catalysts prepared following the conventional thermal evaporation drying method (TED-cat). In addition, the VFD method helps to improve the dispersion of precursors, which then enhances the strong metal-support interactions (MSI) of VFD-cat via forming substoichiometric NiAl2O4 spinel. Characterization showed that the average nickel particle size on the VFD-cat was smaller than that of the TED-cat, attributed to the confinement effects of MSI. At 800 °C, the VFD-cat exhibited higher stability during the long-term dry reforming of methane (DRM) test. It was found that the coke formation on spent VFD-cat, especially for the ordered carbon species, was significantly eliminated as compared with TED-cat after the stability test. This strategy offers a facile way to develop DRM catalysts with highly mesoporous and MSI, enhancing the catalytic stability and coke resistance of the nickel-aluminium catalyst.