bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identifying context-specific domains for assessing antimicrobial stewardship programmes in Asia: protocol for a scoping review
Authors: Vu Huong Thi Lan , Hamers Raph L , Limato Ralalicia , Limmathurotsakul Direk , Karkey Abhilasha , Dodds Ashley Elizabeth , Anderson Deverick , Patel Payal K , Patel Twisha S , Lessa Fernanda C , van Doorn H Rogier 
Published: September 2022

IntroductionAntimicrobial stewardship (AMS) is an important strategy to control antimicrobial resistance. Resources are available to provide guidance for design and implementation of AMS programmes, however these may have limited applicability in resource-limited settings including those in Asia. This scoping review aims to identify context-specific domains and items for the development of a healthcare facility (HCF)-level tool to guide AMS implementation in Asia.Methods and analysisThis review is the first step in a larger project to assess AMS implementation, needs and gaps in Asia. We will employ a deductive qualitative approach to identify locally appropriate domains and items of AMS implementation guided by Nilsen and Bernhardsson’s contextual dimensions. This process is also informed by discussions from a technical advisory group coordinated by the US Centers for Disease Control and Prevention to develop an AMS HCF-level assessment tool for low-income and middle-income countries. We will review English-language documents that discuss HCF-level implementation, including those describing frameworks, components/elements or recommendations for design, implementation or assessment globally and specific to Asia. We have performed the search in August–September 2021 including general electronic databases (MEDLINE, Embase, Web of Science and Google Scholar), region-specific databases, national action plans, grey literature sources and reference lists to identify eligible documents. Country-specific documents will be restricted to countries in three subregions: South Asia, East Asia and Southeast Asia. Codes and themes will be derived through a content analysis, classified following the predefined context dimensions and used for developing domains and items of the assessment tool.Ethics and disseminationResults from this review will feed into our stepwise process for developing a context-specific HCF-level assessment tool for AMS programmes to assess the implementation status, identify intervention opportunities and monitor progress over time. The process will be done in consultation with local stakeholders, the end-users of the generated knowledge.
Analysis of suicide risk in adult US patients with squamous cell carcinoma: a retrospective study based on the Surveillance, Epidemiology and End Results database
Authors: Yu Haohui , Tao Shengru , She Wenli , Liu Min , Wu Yayun , Lyu Jun 
Published: September 2022

ObjectivesThe purpose of this study was to determine the risk factors for suicide in patients with squamous cell carcinoma (SCC) in the USA.SettingPatients with SCC diagnosed between 1975 and 2017 from the Surveillance, Epidemiology and End Results (SEER) database were selected for this study.ParticipantsThis study included patients with SCC older than 20 years who were diagnosed between 1975 and 2017.Primary and secondary outcome measuresThe general population included in data from the US Centers for Disease Control and Prevention were used to calculate the suicide rate and standardised mortality rate (SMR) of SCC patients. Univariate and multivariate Cox regression analyses were used to identify risk factors for suicide in patients with SCC.ResultsThere were 415 268 SCC patients registered in the SEER database, among which 1157 cases of suicide were found, comprising a total of 2 289 772 person-years. The suicide rate for patients with SCC was 50.53 per 100 000 person-years, and the SMR was 4.13 (95% CI 3.90 to 4.38). The Cox regression analyses showed that the factors related to a high risk of suicide among patients with SCC included being male (vs female: HR 5.36, 95% CI 4.51 to 6.38, p<0.001), older at the diagnosis (70–79 vs ≤39 years: HR 1.46, 95% CI 1.09 to 2.08, p=0.012; ≥80 vs ≤39 years: HR 1.48, 95% CI 1.05 to 2.08, p=0.025) and white (vs black, HR 2.97, 95% CI 2.20 to 4.02, p<0.001) and surgery (vs not performed: HR 0.65, 95% CI 0.57 to 0.74, p<0.001).ConclusionsCompared with the general population, patients with SCC in the USA have a higher risk of suicide. Being male, older at the diagnosis, white and having a higher histological grade are risk factors for suicide in patients.
Using Systemised Nomenclature of Medicine (SNOMED) codes to select digital pathology whole slide images for long-term archiving
Authors: Ali Mahmoud , Evans Harriet , Whitney Peter , Minhas Fayyaz , Snead David R J 
Published: September 2022

The archiving of whole slide images represents a hurdle to digital pathology implementation largely because of the amount of data generated. The retention of glass slides is currently recommended for a minimum of 10 years, but it is for individual departments to determine how digital images are archived and for how long. In a retrospective study, we examined the combination of Systemised Nomenclature of Medicine (SNOMED) codes allocated to cases reported between July 2011 and December 2015 and recalled more than 12 months after diagnosis in comparison to non-recalled cases.Our results show that 0.2% of cases are recalled after 12 months, and SNOMED code combinations can be used to identify which cases are likely to be recalled and which are not. This approach could reduce the number of cases archived by 62% and still ensure all cases likely to be recalled remain in the archive.
Thermodynamic studies of the rainbow gravity-inspired higher-dimensional Schwarzschild black hole: Snyder–de Sitter model
Authors: Haldar Amritendu , Haldar Anendu 
Published: September 2022

One of the staple objectives of theoretical physics is to establish a reliable theory of quantum gravity. To achieve this goal, some fundamental scales are proposed in the modern era, e.g. two scales are proposed in the Snyder–de Sitter model. These two scales relate to measurement limits of the position and momentum. In this paper, we study the thermodynamic properties of the higher-dimensional Schwarzschild black hole in the context of rainbow gravity in the Snyder–de Sitter model within the presence and absence of rainbow gravity and compare our results for [Formula: see text] with the results which are already derived in the previous literature [B. Hamil and B. C. Lütfüoğlu, Int. J. Geom. Methods Mod. Phys. 19, 2250047 (2022)]. We find the existence of the remnant temperature of the concerned black hole. Unlike the four-dimensional Schwarzschild black hole, the black hole in higher dimensions [Formula: see text] has two remnant temperatures. Moreover, we observe that in the rainbow gravity background a nonzero lower bound value of the temperature of the black hole exists. Finally, we analyze the thermal stability remnant conditions of the black hole by computing the heat capacity within this model.
Room-temperature superconductivity — or not? Comment on Nature 586, 373 (2020) by E. Snider et al.
Authors: Marel D. van der , Hirsch J. E. 
Published: September 2022

Recently, the discovery of room-temperature superconductivity was announced for a carbonaceous sulfur hydride (CSH) under high pressure [E. Snider et al., Nature 586, 373 (2020)]. The evidence for superconductivity was based on resistance and magnetic susceptibility measurements. In the figures showing the susceptibility it was stated that “the background signal, determined from a nonsuperconducting CSH sample at 108 GPa, has been subtracted from the data”. From a thorough data analysis we show that the data are incompatible with the notion that the susceptibility data are obtained from the “measured voltage” using a background correction. On the other hand, the data are compatible with the reverse procedure, namely the “measured voltage” is obtained by adding a “background signal” containing noise to what was reported as the background-corrected susceptibility. For all six of the reported pressures our analysis leads to the conclusion that: (i) the reported background-corrected susceptibility data are pathological, (ii) they were not obtained by the method described in this paper nor by any one of the alternative three methods that were subsequently provided by the authors and (iii) the “measured voltage” data are not raw data.
Geochemical and mineralogical soil survey of the conterminous USA: a project retrospective
Authors: Smith David B. 
Published: September 2022

From 2007 to 2010, the United States Geological Survey (USGS) conducted a low-density (one site per 1600 km
2
), geochemical and mineralogical soil survey of the conterminous USA (
c
. 8 × 10
6
km
2
). This project was initiated to address the lack of a national soil geochemical database that was a critical need for state and federal environmental agencies, public health specialists and those engaged in risk assessment of contaminated land. Sampling and analytical protocols were developed in consultation with stakeholders at a 2003 workshop, and pilot studies were carried out from 2004 to 2007. Sampling began in 2007 and concluded in 2010. Chemical and mineralogical analyses were completed in 2013, and the datasets were released to the public that same year. Geochemical and mineralogical maps were published in 2014, and an interactive website was released in 2019. The author was Project Chief for this effort throughout the lifetime of the study. The evolution of the project is discussed from its inception through to the publication of results and its impact. The lessons learned during the project are reviewed in the hope that applied geochemists who undertake such broad-scale geochemical mapping projects in the future will find them useful.

Thematic collection:
This article is part of the Continental-scale geochemical mapping collection available at:
https://www.lyellcollection.org/topic/collections/continental-scale-geochemical-mapping
Tamera: Contactless Commodity Tracking, Material and Shopping Behavior Recognition Using COTS RFIDs
Authors: Shang Fei , Yang Panlong , Xiong Jie , Feng Yuanhao , Li Xiangyang 
Published: September 2022

RFID technology has recently been exploited for not only identification but also fine-grained trajectory tracking and gesture recognition. While contact-based (a tag is attached to the target of interest) sensing has achieved promising results, contactless sensing still faces severe challenges such as low accuracy and inability to sense multiple targets simultaneously in proximity, restricting its applicability in real-world deployment. In this work, we present
Tamera
, a contactless RFID-based sensing system, which significantly improves the tracking accuracy, enables multi-commodity tracking, and even material and shopping behavior recognition. We successfully address multiple technical challenges, and design and implement our prototype on commodity RFID devices. We test the positioning accuracy of
Tamera
in a 5 m × 6 m laboratory.
Tamera
achieves a median error of 1.3 cm and 2.7 cm for contactless single- and multi-commodity tracking, respectively. In our laboratory, two shelves commonly found in the supermarket are arranged and the goods are placed on them.
Tamera
successfully localizes and identifies the material type (metal, plastic, paper, and glass) of the commodities on the shelf with an accuracy higher than 95%.
Tamera
successfully recognizes four shopping behaviors (taking commodity, replacing commodity, buying commodity, and invoking commodity) with an accuracy higher than 93%.
Systemic Chemotherapies Retain Antitumor Activity in Desmoid Tumors Independent of Specific Mutations inCTNNB1orAPC: A Multi-institutional Retrospective Study
Authors: Nathenson Michael J. , Hu Junxiao , Ratan Ravin , Somaiah Neeta , Hsu Robert , DeMaria Peter J. , Catoe Heath W. , Pang Angela , Subhawong Ty K. , Amini Behrang , Sweet Kevin , Feister Katharina , Malik Karan , Jagannathan Jyothi , Braschi-Amirfarzan Marta , Sheren Jamie , Caldas Yupanqui , Moreno Tellez Cristiam , Rosenberg Andrew E. , Lazar Alexander J. , Maki Robert G. , Benedetto Pasquale , Cohen Jonathan , Trent Jonathan C. , Ravi Vinod , Patel Shreyaskumar , Wilky Breelyn A. 
Published: September 2022

AbstractPurpose:Determine whether specific CTNNB1 or APC mutations in patients with desmoid tumor were associated with differences in clinical responses to systemic treatments.Experimental Design:We established a multi-institutional dataset of previously treated patients with desmoid tumor across four U.S. sarcoma centers, including demographic and clinicopathologic characteristics, treatment regimens, and clinical and radiographic responses. CTNNB1 or APC mutation status was determined from prior pathology records, or archival tissue was requested and analyzed by Sanger sequencing and/or next-generation sequencing. Evaluable patients with mutation results were analyzed to determine clinical progression-free survival (cPFS), RECIST 1.1 PFS (rPFS), time to next treatment (TTNT), and overall survival (OS). Kaplan–Meier analysis and Cox proportional hazards regression were performed to identify differences in cPFS, rPFS, TTNT, and OS by mutation subtype, desmoid tumor location, and treatment regimen.Results:A total of 259 evaluable patients were analyzed for at least one of the survival outcomes, with 177 patients having mutation data. First- and second-line cPFS, rPFS, and TTNT were not significantly affected by mutation subtype; however, APC-mutant desmoid tumors demonstrated nonstatistically significant inferior outcomes. Extremity/trunk desmoid tumor location and treatment with doxorubicin-based, methotrexate/vinca alkaloids and sorafenib regimens were associated with better clinical outcomes compared with surgery or “other” therapies, including estrogen-receptor blockade and imatinib. OS was significantly worse with APC or CTNNB1 negative/other mutations.Conclusions:Mutation subtype did not affect responses to specific systemic therapies. APC mutations and nonextremity desmoid tumor locations remain prognostic for worse outcomes, and earlier initiation of systemic therapy for these higher-risk desmoid tumors should be prospectively evaluated.See related commentary by Greene and Van Tine, p. 3911
Baseline Serum Autoantibody Signatures Predict Recurrence and Toxicity in Melanoma Patients Receiving Adjuvant Immune Checkpoint Blockade
Authors: Johannet Paul , Liu Wenke , Fenyo David , Wind-Rotolo Megan , Krogsgaard Michelle , Mehnert Janice M. , Weber Jeffrey S. , Zhong Judy , Osman Iman 
Published: September 2022

AbstractPurpose:Adjuvant immunotherapy produces durable benefit for patients with resected melanoma, but many develop recurrence and/or immune-related adverse events (irAE). We investigated whether baseline serum autoantibody (autoAb) signatures predicted recurrence and severe toxicity in patients treated with adjuvant nivolumab, ipilimumab, or ipilimumab plus nivolumab.Experimental Design:This study included 950 patients: 565 from CheckMate 238 (408 ipilimumab versus 157 nivolumab) and 385 from CheckMate 915 (190 nivolumab versus 195 ipilimumab plus nivolumab). Serum autoAbs were profiled using the HuProt Human Proteome Microarray v4.0 (CDI Laboratories, Mayaguez, PR). Analysis of baseline differentially expressed autoAbs was followed by recurrence and severe toxicity signature building for each regimen, testing of the signatures, and additional independent validation for nivolumab using patients from CheckMate 915.Results:In the nivolumab independent validation cohort, high recurrence score predicted significantly worse recurrence-free survival [RFS; adjusted HR (aHR), 3.60; 95% confidence interval (CI), 1.98–6.55], and outperformed a model composed of clinical variables including PD-L1 expression (P &lt; 0.001). Severe toxicity score was a significant predictor of severe irAEs (aHR, 13.53; 95% CI, 2.59–86.65). In the ipilimumab test cohort, high recurrence score was associated with significantly worse RFS (aHR, 3.21; 95% CI, 1.38–7.45) and severe toxicity score significantly predicted severe irAEs (aHR, 11.04; 95% CI, 3.84–37.25). In the ipilimumab plus nivolumab test cohort, high autoAb recurrence score was associated with significantly worse RFS (aHR, 6.45; 95% CI, 1.48–28.02), and high severe toxicity score was significantly associated with severe irAEs (aHR, 23.44; 95% CI, 4.10–212.50).Conclusions:Baseline serum autoAb signatures predicted recurrence and severe toxicity in patients treated with adjuvant immunotherapy. Prospective testing of the signatures that include datasets with longer follow-up and rare but more severe toxicities will help determine their generalizability and potential clinical utility.See related commentary by Hassel and Luke, p. 3914
Randomized Phase II Study of Physiologic MRI-Directed Adaptive Radiation Boost in Poor Prognosis Head and Neck Cancer
Authors: Mierzwa Michelle L. , Aryal Madhava , Lee Choonik , Schipper Matthew , VanTil Monica , Morales Krystal , Swiecicki Paul L. , Casper Keith A. , Malloy Kelly M. , Spector Matthew E. , Shuman Andrew G. , Chinn Steven B. , Prince Mark E.P. , Stucken Chaz L. , Rosko Andrew J. , Lawrence Theodore S. , Brenner J. Chad , Rosen Benjamin , Schonewolf Caitlin A. , Shah Jennifer , Eisbruch Avraham , Worden Francis P. , Cao Yue 
Published: September 2022

Abstract

Purpose:
We conducted a randomized phase II multicenter clinical trial to test the hypothesis that physiologic MRI-based radiotherapy (RT) dose escalation would improve the outcome of patients with poor prognosis head and neck cancer.

Patients and Methods:
MRI was acquired at baseline and at RT fraction 10 to create low blood volume/apparent diffusion coefficient maps for RT boost subvolume definition in gross tumor volume. Patients were randomized to receive 70 Gy (standard RT) or 80 Gy to the boost subvolume (RT boost) with concurrent weekly platinum. The primary endpoint was disease-free survival (DFS) with significance defined at a one-sided 0.1 level, and secondary endpoints included locoregional failure (LRF), overall survival (OS), comparison of adverse events and patient reported outcomes (PRO).

Results:
Among 81 randomized patients, neither the primary endpoint of DFS (HR = 0.849, P = 0.31) nor OS (HR = 1.19, P = 0.66) was significantly improved in the RT boost arm. However, the incidence of LRF was significantly improved with the addition of the RT boost (HR = 0.43, P = 0.047). Two-year estimates [90% confidence interval (CI)] of the cumulative incidence of LRF were 40% (27%–53%) in the standard RT arm and 18% (10%–31%) in the RT boost arm. Two-year estimates (90% CI) for DFS were 48% (34%–60%) in the standard RT arm and 57% (43%–69%) in the RT boost arm. There were no significant differences in toxicity or longitudinal differences seen in EORTC QLQ30/HN35 subscales between treatment arms in linear mixed-effects models.

Conclusions:
Physiologic MRI-based RT boost decreased LRF without a significant increase in grade 3+ toxicity or longitudinal PRO differences, but did not significantly improve DFS or OS. Additional improvements in systemic therapy are likely necessary to realize improvements in DFS and OS.
Autoantibodies as Predictors for Clinical Outcome and Toxicity for Immunotherapy
Authors: Hassel Jessica C. , Luke Jason J. 
Published: September 2022

SummaryPeripheral blood autoantibody signatures might be useful biomarkers of immunotherapy outcome. Signatures predicting melanoma recurrence and toxicity during adjuvant immunotherapy were recently presented. Whether autoantibodies are bystanders or have a pathophysiologic role is unknown, and further efforts are needed to investigate potential mechanisms and determine causation.See related article by Johannet et al., p. 4121
Ethnic and Racial Diversity Among Surgeon and Non-Surgeon Deans of Allopathic Medical Schools
Authors: Choubey Ankur P. , Ortiz Alejandro , Parsikia Afshin , Choubey Apurva S. , Jetjomlong Tyler , Martinez Abigail , Abreu Carina , Koizumi Naoru , Ortiz Jorge 
Published: September 2022

Introduction Previous publications have assessed the diversity among medical students, residents, faculty, and department leaders in surgery and medicine overall. We aim to evaluate the diversity among medical school deans in the United States. We quantify and compare the representation of women and underrepresented minority surgeon and non-surgeons. Methods 151 allopathic medical schools were included. Data regarding demographics, education, training, and previous leadership position were collected from institutional websites, online resources, and July 2021 Association of American Medical Colleges Council of Deans. Demographics for surgeon and non-surgeon were compared using chi square and logistic regression with 5% significance interval. Results 21.9% (n = 33) of all medical school deans were surgeons. 21.2% (n = 7) were women, which was not significantly different from non-surgeons (22%, P = .92). All the women surgeons were non-Hispanic white, similar to all deans ( P = .83). 78.8% (n = 26) of all surgeon deans were non-Hispanic White compared to 84.7% (n = 100) overall ( P = .28). There were 13 Black deans, four of whom were surgeons, and only one Hispanic dean, who was not a surgeon. Surgeons were more likely to be fellows of their professional society ( P = .012). Conclusion The demographic diversity of surgeon and non-surgeon US medical school deans is not significantly different. The deficiencies in leadership diversity in medicine persists among medical school deans. There remains substantial room to improve the representation of women and underrepresented minorities as deans.
Understanding Farmer Producer Company (FPC) Ecosystem in Assam: Issues and Challenges
Authors: Bhuyan Ratna , Das Bhargab , Khound Sampurna 
Published: September 2022

The agriculture sector, which continues to be pivotal to sustainable growth and development, has been recently mobilising farmers into member-owned producer organisations, or Farmer Producer Companies (FPCs) to enhance production, productivity and profitability of agriculturists, especially the small and marginal farmers in the country. The FPCs, which have been brought in for improved transparency and access to the input and output market with higher negotiating powers leading to sustainability of the small and marginal farmers, are said to provide higher legitimacy and credibility in the immediate business environment. Though Assam too is not behind in forming FPCs, challenges and issues abound. Majority of these FPCs are in the nascent stage of their operations with shareholder membership ranging from more than 500 farmers to over 1500 farmers. It is also seen that from capacity building to taking up business operations, many issues need to be addressed in these FPCs. These FPCs are in need of support in technical handholding and provision of adequate capital and infrastructure facilities including market linkages for sustaining their business operations. The present paper tries exploring and understanding the ecosystem of the FPCs in Assam, which are focussing on small and marginal farmers, and delving into the issues and challenges faced by the FPCs in the state and the possible ways out. JEL Classification: Q13