bluuebunny/crossref_metadata_2025_split huggingface dataset:
Women’s Practices of Everyday Life in the Conditions of the Ukrainian Village in the First Years of Post-War Reconstruction (1944-1947)
Authors: Starodubets Galyna 
Published: October 2022

The purpose of article is to use the example of Zhytomyr Oblast and describe the daily survival practices of women collective farmers in the conditions of the reconstruction of the collective farm system and the famine of 1946-1947 and the peculiarities of their perception of those transformational processes, which they were witnesses and participants of.
Scientific novelty. The topic of everyday life in the Ukrainian village in the period of late Stalinism is considered from the aspect of experience of Ukrainian collective farmers women for the first time in Ukrainian historiography.
Conclusion. The core of the post-war reconstruction of the Ukrainian village was the restoration of the collective farm system. Given the changes in the demographic situation caused by the war and the German occupation of Ukrainian territories, women were the main mobilization resource for replenishing the ranks of collective farm workers. The memories of peasant women/peasants of Zhytomyr region provide grounds for the conclusion that in the period under study, the collective farm system had a distinctly discriminatory nature for women. Labor relations in the structure of the collective farm, which during the famine of 1946-1947 had a repressive character, had a dominant influence on the everyday lifestyle of the rural family.
According to the stories of our respondents, in the period we studied, the responsibility for the survival of the family mostly rested on the woman-mother. In historiography, this status of hers is usually called ‘double burden’. There have been certain changes in the spatial and temporal dimensions of women’s everyday life. The woman had to combine hard work in the collective farm with work in the household and care and upbringing of children. During the famine of 1946-1947, women’s survival practices to some extent depended on her status: either she was a ‘widow’ (the breadwinner of the family) or ‘had a husband’ (responsibility for providing for the family was shared between spouses). In general, it can be confidently asserted that the strategies of everyday behavior of the peasants in the first years of post-war reconstruction had a clear imprint of gender-colored labeling.
Diagnosis values of Dectin-1 and IL-17 levels in plasma for invasive pulmonary aspergillosis in bronchiectasis
Authors: He Qian , Li Min , Cao Jiaqi , Zhang Ming , Feng Chunlai 
Published: October 2022

BackgroundAmong immunocompetent patients, patients with bronchiectasis are considered to be a high-risk group for invasive pulmonary aspergillosis (IPA). Early diagnosis and treatment can improve the prognosis of patients.ObjectivesWe aimed to investigate the diagnostic value of Dectin-1 and IL-17 for diagnosing IPA with bronchiectasis.MethodsWe retrospectively collected data on patients with bronchiectasis who had been hospitalized in the Third Affiliated Hospital of Soochow University between September 2018 to December 2021. Dectin-1, IL-17 and GM were measured by enzyme-linked immunosorbent assays.ResultsA total of 129 patients were analyzed in the study, of whom 33 had proven or probable IPA with bronchiectasis. The remaining 96 patients served as controls. The plasma Dectin-1 and IL-17 levels in the IPA group were significantly higher than that in the control group (P=0.005; P&lt;0.001). The plasma GM, BALF GM, plasma Dectin-1 and IL-17 assays had sensitivities of 39.4%, 62.5%, 69.7% and 78.8%, respectively, and specificities of 89.2%, 91.5%, 72.9% and 71.9%, respectively. The sensitivity of Dectin-1 and IL-17 in plasma was higher than that in plasma and BALF GM. while the specificity is lower than that of plasma and BALF GM. The diagnostic sensitivity and specificity of plasma GM combined with IL-17 for IPA in bronchiectasis were greater than 80%. The combination of plasma GM and IL-17 can improve the sensitivity of the GM test, but does not reduce the diagnostic specificity. The plasma Dectin-1 and IL-17 showed positive linear correlations with the bronchiectasis severity Index (BSI) score in linear regression.ConclusionsPlasma Dectin-1 and IL-17 levels were significantly higher in bronchiectasis patients with IPA. The sensitivity of Dectin-1 and IL-17 was superior to that of GM for the diagnosis of IPA in patients with bronchiectasis. The combination of GM and IL-17 in plasma is helpful for the diagnosis of IPA in bronchiectasis patients who cannot tolerate invasive procedures.
Safety of transesophageal echocardiography during transcatheter edge-to-edge tricuspid valve repair: A single-center experience
Authors: Hellhammer Katharina , Schueler Robert , Eißmann Mareike , Schumacher Brigitte , Wolf Alexander , Bruder Oliver , Schmitz Thomas , Lambers Moritz 
Published: October 2022

ObjectivesWe aimed to determine transesophageal echocardiography (TEE) related complications during Transcatheter edge-to-edge tricuspid valve repair (TTVR).BackgroundTransesophageal echocardiography is essential to guide structural heart disease (SHD) interventions. TTVR has become an evolving procedure for high-risk patients not suitable for surgery. Whether this complex procedure is associated with TEE related complications is not known so far.MethodsWe retrospectively analyzed 64 consecutive patients undergoing TTVR between 2019 and 2021 with the TriClip system (Abbott, Chicago, IL, USA) at our center. All procedures were performed under general anesthesia (GA). TEE related complications were classified as major and minor complications.ResultsTransesophageal echocardiography related complications were observed in two patients (3.1%) with one major complication (1.6%) and one minor complication (1.6%). In one patient perforation of the esophageal mucosa requiring red blood cell transfusion was observed, the other patient had hematemesis due to minor esophageal and gastric lesions without the need for blood transfusion. Both patients recovered during hospital stay with no persistent symptoms at discharge.ConclusionsTransesophageal echocardiography related complications during TTVR are clinically relevant occurring in 3.1% of the patients. Further investigations are needed to identify potential risk factors and patients at high risk to develop a TEE related complication in the course of TTVR.
Five-years’ prognostic analysis for coronary artery ectasia patients with coronary atherosclerosis: A retrospective cohort study
Authors: Liu Ruifeng , Gao Xiangyu , Liang Siwen , Zhao Huiqiang 
Published: October 2022

BackgroundMost of coronary artery ectasia (CAE) patients have comorbid coronary atherosclerosis. It was lack of prognostic data for CAE patients with coronary heart disease (CHD) and for whom with acute myocardial infarction (AMI).ObjectiveTo determine the overall prognosis for CAE patients.Materials and methodsThis study was a retrospective cohort study. Fifty-one patients with CAE and comorbid AMI (CAE + AMI) and 108 patients with CAE and comorbid CHD (CAE + CHD) were enrolled and matched to non-CAE subjects at a ratio of 1:3 using a propensity score method, respectively. Controls for CAE + AMI group were 153 AMI patients, controls for CAE group were 324 CHD patients and 329 participants with relatively normal coronary arteries (CON). We followed them up to observe major cardiovascular events (MACE).ResultsThe Kaplan-Meier curves showed that the prognosis in CAE + AMI group was worse than in AMI group (5-year non-MACE rate: 62.70% vs. 79.70%, P = 0.010), the prognosis in CAE group was worse than in CHD and CON groups (5-year non-MACE rate: 74.10% vs. 85.80% and 96.70%, respectively, P = 0.000). The main MACEs in CAE + AMI and CAE groups were AMI reoccurrence (19.61% vs. 4.57%, P = 0.002) and re-hospitalization due to repeated angina pectoris (14.81% vs. 8.33% and 2.74%, P = 0.000), respectively. Additionally, the COX regression analysis revealed that the protective factors for preventing MACE in CAE + AMI group included antiplatelet agents (hazard ratio = 0.234, P = 0.016) and angiotensin-converting enzyme inhibitor/angiotensin receptor inhibitor (ACEI/ARB, hazard ratio = 0.317, P = 0.037). Whereas the main factor promoting MACE in CAE group was the degree of coronary stenosis (Gensini score, hazard ratio = 1.011, P = 0.022).ConclusionThe prognosis of patients with CAE + AMI was worse than that of those with AMI. The overall prognosis of patients with CAE was worse than that of those with CHD. CAE + AMI and CAE groups had different characteristics; the former was prone to AMI reoccurrence, and the latter was prone to repeated angina pectoris. To prevent MACE, medications, including antiplatelets and ACEI/ARBs, are indicated for patients with CAE + AMI, whereas prevention of the progression of atherosclerotic lesions is indicated for patients with CAE.
Central Asia daily extreme precipitation in observations and gridded datasets: A threshold criteria perspective
Authors: Chen Jing , Yao Junqiang , Dilinuer Tuoliewubieke , Li Jiangang , Li Shujuan , Yang Lianmei , Mao Weiyi 
Published: October 2022

The extreme precipitation threshold is fundamental to extreme precipitation research, directly affecting the cognition of extreme characteristics. Based on the daily precipitation data of 62 meteorological stations from 1985 to 2005, this study uses parametric and non-parametric approaches to determine the extreme precipitation threshold in Central Asia, analyzes the statistics and spatial distribution of different threshold criteria, and discusses the trend of extreme precipitation. The capability of the grid dataset of APHRODITE and GPCC in the extreme precipitation analysis in Central Asia is evaluated from the threshold perspective. The results are as follows: 1) Contrary to the parametric approach, the threshold determined by the percentile indices in the warm season is slightly higher than in the cold season. The mean threshold of the warm (cold) season in Central Asia is defined by the 95th percentile index and the 10-year return period, which are 14.0 mm (13.5 mm) and 24.2 mm (25.7 mm), respectively. 2) The spatial distribution of extreme precipitation threshold in Central Asia is higher in the southeast and lower in the north during the cold season; In the warm season, it is high in the north and southwest and low in the center. 3) Although both APHRODITE and GPCC datasets can basically reproduce the spatial distribution of extreme precipitation threshold, they underestimate the magnitude of the threshold, especially APHRODITE. 4) There is no obvious extreme precipitation trend in Central Asia during the study period. Furthermore, the trend in characteristics of extreme precipitation based on different thresholds shows a consistent trend in time but not spatially. We suggest that the threshold selection should adjust the balance between sufficient samples and extreme values according to actual conditions. The results of this study can provide a reference for extreme precipitation threshold criteria under specific application conditions in Central Asia.
Pembrolizumab in Chinese patients with advanced melanoma: 3-year follow-up of the KEYNOTE-151 study
Authors: Si Lu , Zhang Xiaoshi , Shu Yongqian , Pan Hongming , Wu Di , Liu Jiwei , Mao Lili , Wang Xuan , Wen Xizhi , Gu Yanhong , Zhu Lingjun , Lan Shijie , Cai Xin , Diede Scott J. , Dai Haiyan , Niu Cuizhen , Li Jianfeng , Guo Jun 
Published: October 2022

Survival is generally poor for Chinese patients with advanced melanoma because of high rates of acral and mucosal melanoma and limited therapeutic options. The first analysis of the phase 1b KEYNOTE-151 study showed second-line pembrolizumab was well tolerated and had clinically meaningful antitumor activity in Chinese patients with advanced melanoma. Three-year follow-up is presented. Eligible patients were of Chinese descent and had unresectable stage III/IV melanoma that progressed after first-line therapy. Patients received pembrolizumab 2 mg/kg every 3 weeks for ≤35 cycles. Primary end points were safety and objective response rate (ORR). Secondary end points included duration of response (DOR), progression-free survival (PFS), and overall survival (OS). Response was assessed per RECIST v1.1 by blinded independent central review. Subgroup analyses were conducted by melanoma subtype and BRAF and PD-L1 status (acral melanoma only). 103 patients were enrolled; median follow-up duration (time from first dose to data cutoff [July 13, 2020]) was 44.6 months (IQR, 39.1–46.2). Any-grade treatment-related adverse events (TRAEs) occurred in 85.4% of patients, and grade 3/4 TRAEs in 12.6%. No grade 5 TRAEs occurred. Three patients discontinued pembrolizumab because of TRAEs (immune-mediated hepatitis, pneumonia, and arthritis). Immune-mediated AEs and infusion reactions occurred in 34.0% (grade 3/4, 2.9%). ORR was 17.6% (95% CI, 10.8–26.4; 1 complete response/17 partial responses), and median DOR was 13.8 months (range, 2.7–37.4+). Median PFS was 2.8 months (95% CI, 2.7–3.5) and 36-month PFS rate was 5.0%. Median OS was 13.2 months (95% CI, 10.4–16.5) and 36-month OS rate was 22.3%. Median OS for patients with known melanoma subtype was 14.8 months for acral, 13.5 months for nonacral cutaneous, and 7.4 months for mucosal melanoma. Among the acral subgroup, median OS was 22.8 months for PD-L1–positive disease, 8.4 months for PD-L1–negative disease, 18.5 months for BRAF wild-type disease, and 5.8 months for BRAF-mutant disease. Over 3 years’ follow-up, second-line pembrolizumab continued to show manageable safety, clinically meaningful antitumor activity, and durable responses in Chinese patients with advanced melanoma. Subgroup analysis suggested particular benefit in PD-L1–positive and BRAF wild-type acral melanoma, although small subgroup sizes preclude definitive conclusions.Clinical trial registrationhttps://clinicaltrials.gov, identifier NCT02821000.
Disruption of white matter integrity and its relationship with cognitive function in non-severe traumatic brain injury
Authors: Abdullah Aimi Nadhiah , Ahmad Asma Hayati , Zakaria Rahimah , Tamam Sofina , Abd Hamid Aini Ismafairus , Chai Wen Jia , Omar Hazim , Abdul Rahman Muhammad Riddha , Fitzrol Diana Noma , Idris Zamzuri , Ghani Abdul Rahman Izaini , Wan Mohamad Wan Nor Azlen , Mustafar Faiz , Hanafi Muhammad Hafiz , Reza Mohamed Faruque , Umar Hafidah , Mohd Zulkifly Mohd Faizal , Ang Song Yee , Zakaria Zaitun , Musa Kamarul Imran , Othman Azizah , Embong Zunaina , Sapiai Nur Asma , Kandasamy Regunath , Ibrahim Haidi , Abdullah Mohd Zaid , Amaruchkul Kannapha , Valdes-Sosa Pedro Antonio , Bringas Vega Maria Luisa , Biswal Bharat , Songsiri Jitkomut , Yaacob Hamwira Sakti , Sumari Putra , Noh Nor Azila , Azman Azlinda , Jamir Singh Paramjit Singh , Abdullah Jafri Malin 
Published: October 2022

BackgroundImpairment in cognitive function is a recognized outcome of traumatic brain injury (TBI). However, the degree of impairment has variable relationship with TBI severity and time post injury. The underlying pathology is often due to diffuse axonal injury that has been found even in mild TBI. In this study, we examine the state of white matter putative connectivity in patients with non-severe TBI in the subacute phase, i.e., within 10 weeks of injury and determine its relationship with neuropsychological scores.MethodsWe conducted a case-control prospective study involving 11 male adult patients with non-severe TBI and an age-matched control group of 11 adult male volunteers. Diffusion MRI scanning and neuropsychological tests were administered within 10 weeks post injury. The difference in fractional anisotropy (FA) values between the patient and control groups was examined using tract-based spatial statistics. The FA values that were significantly different between patients and controls were then correlated with neuropsychological tests in the patient group.ResultsSeveral clusters with peak voxels of significant FA reductions (p &lt; 0.05) in the white matter skeleton were seen in patients compared to the control group. These clusters were located in the superior fronto-occipital fasciculus, superior longitudinal fasciculus, uncinate fasciculus, and cingulum, as well as white matter fibers in the area of genu of corpus callosum, anterior corona radiata, superior corona radiata, anterior thalamic radiation and part of inferior frontal gyrus. Mean global FA magnitude correlated significantly with MAVLT immediate recall scores while matrix reasoning scores correlated positively with FA values in the area of right superior fronto-occipital fasciculus and left anterior corona radiata.ConclusionThe non-severe TBI patients had abnormally reduced FA values in multiple regions compared to controls that correlated with several measures of executive function during the sub-acute phase of TBI.
Clinical comparison of two automated audiometry procedures
Authors: Liu Hui , Du Bingqing , Liu Bo , Fu Xinxing , Wang Yao 
Published: October 2022

ObjectiveAutomated pure-tone audiometry has been shown to provide similar hearing threshold estimates to conventional audiometry, but lower correlations were reported at high and low frequencies in audiometric tests than those of manual tests, while the correlations were better in the middle frequencies. In this paper, we used the same equipment and different test procedures for automated testing, and compared the results with manual test results.DesignOne hundred subjects aged 18–36 years were randomly divided into two groups to perform air-conduction pure-tone audiometry (0.25, 0.5, 1, 2, 4, 8 kHz) using the ascending and shortened ascending protocols built-in to the automated audiometer, respectively. Recorded testing time, the total number of responses and the subject’s preference tests were compared with those of manual tests.ResultsSignificant difference was found at 250 Hz regarding the distribution of the absolute difference between the two automated and the manual thresholds. The testing time spend in the ascending method (9.8 ± 1.4 min, mean ± SD) was significantly longer than in the shorted ascending method (5.8 ± 0.9 min). The total numbers of responses of the ascending method (90.5 ± 10.8 times) and shorted ascending method (62.0 ± 11.4 times) were significantly different. Finally, no significant difference was found in preferences between automated and manual procedures.ConclusionThe shorted ascending method can save lots of testing time. The difference between the two automated thresholds at 250 Hz is caused by the different test procedures, and the difference at 8,000 Hz between the automated test and the manual test can be due to the transducer types and allowable differences in calibration.
Iron overload accelerated lipid metabolism disorder and liver injury in rats with non-alcoholic fatty liver disease
Authors: Zhang Lijia , Dai Xuezheng , Wang Li , Cai Jingming , Shen Jie , Shen Yang , Li Xianan , Zhao Yan 
Published: October 2022

Background/aimsNon-alcoholic fatty liver disease (NAFLD) is one of the most common liver diseases worldwide. Iron overload has been implicated in chronic non-communicable liver diseases, but its relationship with NAFLD remains unclear. This study aimed to investigate the underlying roles of iron overload in the development of NAFLD.MethodsMale Sprague Dawley rats were fed with a high-fat diet (HFD) and/or iron for 8, 12, and 20 weeks. Some rats fed with HFD plus iron also received intraperitoneal injection of deferoxamine (DFO) for 8 weeks. Liver steatosis, lipid metabolism and injury were evaluated.ResultsA NAFLD model, including typical liver steatosis, was established by feeding rats with a HFD, while iron overload alone is not enough to induce severe NAFL. Compared with rats fed a HFD, excess iron further increased lipid accumulation, serum levels of lipids, enzymes of liver function, and expression levels of CD36 and FAS in rat liver. In addition, iron overload decreased the activities of antioxidative enzymes in liver compared with HFD rats. The levels of CPT1 and the ratios of p-ACC/ACC were also decreased by iron overload. DFO effectively reversed the abnormal lipid metabolism and liver damage induced by a high-fat, high-iron diet.ConclusionA HFD plus iron overload might synergistically aggravate lipid metabolism disorders, liver injury, and oxidative damage, compared with a HFD alone. DFO might help to alleviate lipid metabolism dysfunction and improve the pathogenesis of NAFLD.
Automated data preparation for in vivo tumor characterization with machine learning
Authors: Krajnc Denis , Spielvogel Clemens P. , Grahovac Marko , Ecsedi Boglarka , Rasul Sazan , Poetsch Nina , Traub-Weidinger Tatjana , Haug Alexander R. , Ritter Zsombor , Alizadeh Hussain , Hacker Marcus , Beyer Thomas , Papp Laszlo 
Published: October 2022

BackgroundThis study proposes machine learning-driven data preparation (MLDP) for optimal data preparation (DP) prior to building prediction models for cancer cohorts.MethodsA collection of well-established DP methods were incorporated for building the DP pipelines for various clinical cohorts prior to machine learning. Evolutionary algorithm principles combined with hyperparameter optimization were employed to iteratively select the best fitting subset of data preparation algorithms for the given dataset. The proposed method was validated for glioma and prostate single center cohorts by 100-fold Monte Carlo (MC) cross-validation scheme with 80-20% training-validation split ratio. In addition, a dual-center diffuse large B-cell lymphoma (DLBCL) cohort was utilized with Center 1 as training and Center 2 as independent validation datasets to predict cohort-specific clinical endpoints. Five machine learning (ML) classifiers were employed for building prediction models across all analyzed cohorts. Predictive performance was estimated by confusion matrix analytics over the validation sets of each cohort. The performance of each model with and without MLDP, as well as with manually-defined DP were compared in each of the four cohorts.ResultsSixteen of twenty established predictive models demonstrated area under the receiver operator characteristics curve (AUC) performance increase utilizing the MLDP. The MLDP resulted in the highest performance increase for random forest (RF) (+0.16 AUC) and support vector machine (SVM) (+0.13 AUC) model schemes for predicting 36-months survival in the glioma cohort. Single center cohorts resulted in complex (6-7 DP steps) DP pipelines, with a high occurrence of outlier detection, feature selection and synthetic majority oversampling technique (SMOTE). In contrast, the optimal DP pipeline for the dual-center DLBCL cohort only included outlier detection and SMOTE DP steps.ConclusionsThis study demonstrates that data preparation prior to ML prediction model building in cancer cohorts shall be ML-driven itself, yielding optimal prediction models in both single and multi-centric settings.