bluuebunny/crossref_metadata_2025_split huggingface dataset:
PENGARUH MODEL PEMBELAJARAN GAMIFICATION TERHADAP PARTISIPASI SISWA KELAS VI SEKOLAH DASAR
Authors: Rahmatullah Sufyan Syafiq , Mulyadiprana Ahmad , Ganda Nana 
Published: September 2022

Penelitian ini bertujuan mengetahui pengaruh model pembelajaran gamification terhadap partisipasi siswa sekolah dasar. Hal ini karena peneliti menemukan bahwasannya penggunaan model konvensional terlalu sering digunakan mengakibatkan pembelajaran menjadi monoton sehingga membuat siswa bosan selama mengikuti pembelajaran yang berakibat rendahnya partisipasi siswa selama pembelajaran. Model pembelajaran gamification menjadi solusi karena didalamnya menggunakan mekanisme dan elemen layaknya sebuah permainan. Metode penelitian yang digunakan yaitu metode Quasi Eksperimen dengan populasi kelas VI SDN 1 Padaherang dan kelas VI SDN 3 Padaherang. Sampel penelitian ditentukan secara sampling jenuh yaitu kelas VI SDN 1 Padaherang sebanyak 16 siswa sebagai kelas eksperimen dan kelas VI SDN 3 Padaherang sebanyak 16 siswa sebagai kelas kontrol. Instrumen penelitian yang digunakan yakni angket dengan 15 pernyataan. Dalam menganalisis data menggunakan SPSS 25.0. Hasil penelitian ini setelah uji hipotesis menggunakan Uji T menghasilkan thitung = 8.472 dengan signifikansi 5% atau 0,05 menghasilkan ttabel = 2.120. Dengan demikian, pembelajaran yang menerapkan model gamification berpengaruh terhadap partisipasi siswa dibandingkan pembelajaran yang menerapkan model konvensional.
PERFORMANCE AND CARCASES PERCENTAGE OF PEKIN DUCK SUPPLIED WITH SAGO PITH SILAGE AS AN ENERGY SOURCE
Authors: Sulaiman Abrani , Wijayanto Harry , Anwar Khairil , Sumantri Eka , Biyatmoko Danang 
Published: September 2022

The purpose of this study was to determine the optimal level of use of sago pith silage to replace rice bran in the ration on the production performance of male Peking ducks. The research treatments included: T0 = No sago pith silage (control), T1 = Use of 5% sago pith silage in the ration, T2 = Use of 10% sago pith silage in the ration, T3 = Use of 15% sago pith silage in the ration, T4 = Use of sago pith silage 20% in the ration. The experimental diet contained 16% crude protein and 3000 kcal/kg metabolizable energy. The Pekin ducks used in this experiment were 2 weeks old. The research design used was a complete randomized design using five feeding treatments, five replications, and four ducks per replication pens. The parameters measured were feed intake, weight gain, body weight, feed conversion, the percentages of carcass, giblet, and abdominal fat at 8 weeks of age. The results showed that the use of sago pith silage had no significant effect on feed consumption, weight gain, body weight, feed conversion, and the percentages of carcass and giblet. However, the use of sago pith silage increased abdominal fat. It can be concluded that the use of sago pith silage up to 20% to replace rice bran in the ration has no negative effects on the performance and carcass quality of ducks.
Machine Learning based Recommender Systems for Crop Selection: A Systematic Literature Review
Authors: OMMANE Younes , RHANBOURI Mohamed Amine , CHOUIKH Hicham , JBENE Mourad , CHAIRI Ikram , LACHGAR Mohamed , BENJELLOUN Saad 
Published: September 2022

Abstract
This paper draws a systematic literature review about the use of Machine learning based recommender systems for crop selection, with respect to the PRISMA protocol for systematic reviews. The second section, describes an overview of existing recommender systems in literature. The outline of this study is explained, as well as the method of content analysis used in this article to sort out the papers is introduced in the third section. In the fourth section, the selection process and the literature review matrix are provided. Additionally, the evolvement of research on crop recommendation over the years is considered, a detailed study of the main input features is done. Further, the current challenges found in crop recommendation are listed. The fifth section discusses the outcomes of the study. The last section recapitulates the outcomes of the study, shedding the light of research perspectives worthwhile pursuing.
The value of percutaneous ultrasound-guided subacromial bursography in the diagnosis of rotator cuff tears
Authors: Li Ruochen , Li Miao , Cui Yipeng , Yang Pei , Zhang Chen 
Published: September 2022

Abstract
Purpose

To determine the feasibility and diagnostic value of percutaneous ultrasound-guided subacromial bursography (PUSB) in the diagnosis of rotator cuff tears.

Methods

Between July 2019 to October 2021, 78 patients who had suspected rotator cuff injury and who were admitted to the Second Affiliated Hospital of Xi'an Jiaotong University were selected, including 32 males and 46 females, aged 31–70 years (mean age 53.9 ± 9.1 years), with a course of 1D-2 years. The MRI, US and PUSB images of patients were retrospectively analyzed to obtain the diagnostic and predictive indexes (sensitivity, specificity, positive predictive value, negative predictive value and accuracy) of these three methods for different rotator cuff tears types (full-thickness tears, partial-thickness tears and no tears of rotator cuff ). With the results of shoulder arthroscopy serving as the standard, PUSB results were compared with MRI and US results using the X2 -test (α = 0.05, two-sided).

Results

In all 78 patients, the overall accuracy of MRI, US, and PUSB in diagnosing rotator cuff tears was 82.1% (64/78), 75.6% (59/78) and 96.2% (75/78), respectively (P < 0.001). Among 21 patients with full-thickness tears, the numbers of cases correctly diagnosed by MRI, US and PUSB were 19, 19 and 21, respectively. The sensitivity and specificity of MRI, US and PUSB in diagnosing full-thickness tears were 90.5%, 90.5%, 100% and 98.2%, 93.0%, 100%, respectively. The diagnostic accuracies of full-thickness rotator cuff tears were 90.5%, 90.5% and 100%, respectively, with no statistical difference (P = 0.344). Among 42 patients with partial-thickness tears, the numbers of patients whose cases were correctly diagnosed on MRI, US and PUSB were 32, 27 and 40, respectively. The sensitivity and specificity of MRI, US and PUSB in diagnosing partial-thickness tears were 76.2%, 64.3%, and 95.2% and 88.9%, 88.9%, and 97.2%, respectively. The diagnostic accuracies of partial-thickness rotator cuff tears were 76.2% (32/42), 64.3% (27/42) and 95.2% (40/42), respectively (P＜0.05). Among the 15 patients without tears, the numbers of misdiagnosed cases by MRI, US and PUSB were 2, 2, and 1, respectively, and they were all misdiagnosed as partial-thickness tears. The sensitivity and specificity of MRI, US and PUSB in the diagnosis of complete rotator cuff were 86.7%, 86.7%, and 93.3% and 85.7%, 82.5% and 96.8%, respectively, and the accuracies in diagnosing no tears were 86.7% (13/15), 86.7% (13/15) and 87.5% (14/15), respectively (P = 0.997).

Conclusions

It is feasible to diagnose rotator cuff tears by PUSB, which can be used as an important supplement imaging method to evaluate rotator cuff tears.
Red propolis extract in the diet of confined sheep: morphometric alterations of the digestive system
Authors: Garcia Pedro Henrique de Melo , Guerra Ricardo Romão , de Oliveira Juliana Silva , Júnior Dorgival Morais de Lima , de Almeida Vitor Visintin Silva , Silva Edijanio Galdino da , Ribeiro Neila Lidiany 
Published: September 2022

Abstract

This study aimed to evaluate the effect of increasing levels of red propolis extract (RPE) in the diet of confined sheep on performance and histomorphometric parameters of rumen and intestine and histopathological parameters of liver and kidney. Thirty-five male sheep (17.08 ± 2.36 kg) were used, distributed in a completely randomized design, with five treatments (0, 7, 14, 21, and 28 mL day− 1RPE) and seven replications, submitted to one 68-day trial period. At the end of the experimental period, the animals were slaughtered, and, rumen, intestine, liver, and kidney samples were collected (histomorphometry and histopathology). The dry matter intake (DMI), total weight gain (TWG), epithelial thickness ruminal (ETR), a keratinized portion of the epithelium ruminal (KER), a non-keratinized portion of the epithelium ruminal (NKP), papilla height (PH), papilla width (PW), mucosal thickness (MT) and submucosal thickness (ST) exhibited quadratic curve behavior (P < 0.05) with the inclusion of RPE. In addition, the highest level of 28 mL day− 1RPE resulted in a 20.24% increase in TWG compared to the control group. Therefore, the 28 mL day-1 RPE level is indicated as a natural additive more significant to provide greater absorptive areas of the rumen and intestine, and an increase in total weight gain.
Assessment of Groundwater Quality of Hadejia-Jamaare-Komadugu-Yobe Basin of Nigeria, Using Statistical Approach
Authors: A.G. Tahir , M.L. Garba , A. Mustapha , A.N. Ahmad 
Published: September 2022

Abstract
Assessment of the hydro geochemical processes that control groundwater quality is significant for sustainable development of water resource. This paper reports the results of groundwater samples collected from 81 locations of the intensively cultivated areas of the Hadejia-Jamaare-Komadugu-Yobe basin of Nigeria. The study approach employed the use of statistical tools; conventional descriptive statistics and multivariate analysis on the generated hydrochemical data in order to understand the groundwater condition of the area, with a view to define the concentration of different parameters in the water and other factors controlling the groundwater quality. High mean concentration is observed for Electrical conductivity having (322.1 mg/l), HCO3- (221.09mg/l) and TDS (154.32 mg/l). The low mean concentration is found to be (-3.03mg/l) and (0mg/l), for Mo and Ni respectively. The abundance of major cations in the study area shows the trend of Ca2+ > K+, while that of major anion in the descending order of, HCO3- >SO42- >Cl->NO3. Based on the Eigen value-one criterion, eleven (11) components were chosen after Varimax rotation. The 11 Varimax factors together explained 81.91% of the variance of the data. The first Varimax factor (VF1) contained strong factor loading on Pb, Mo, Cd and Ni which account for 15.404% of the total variability of the water quality data. The 2nd Varimax factor (VF2) has strong loading for EC, TDS, Cl and Temperature with variance of 14.068%. The strong loading for EC, TDS and Cl could be due to salinity built-up process in the area as a result of the intensive agricultural activities. The 3rd Varimax factor (VF3) has higher loadings for NO2, NO3, SO4 and HCO3 with variance of 10.075%. These results suggest the possibility of some anthropogenic activities like application of fertilizers and industrial effluents which may have contributed to the high concentration of some parameters. A natural hydro geochemical process like weathering of different igneous and metamorphic rocks at the upstream part of the study area is another possibility that have resulted in the elevated concentration of some parameters.
Performance Analysis of Multiple Strips to Reduce the Separation of Photonic Waveguides in Photonic Array
Authors: R Abinands , Mallick P. S. 
Published: September 2022

AbstractIn order to construct a dense Photonic Integrated Circuit (PIC) that comprises photonic waveguides, it is vital to consider the necessity of low crosstalk between surrounding waveguides. From past literature, higher coupling length can be obtained by utilizing a silicon – on -insulator (SOI) based photonic waveguide with an acceptable waveguide separation between them. The current research aims to reduce waveguide separation and hence increase photonic integration over PICs. Numerous strips were inserted between the photonic waveguides to achieve this. The impact of modifications in height and width of three, four, and five strips on coupling has been analyzed. This has led to the inference that larger coupling lengths can be achieved. The greatest coupling lengths of 485 µm, 620 µm, and 104110 µm were reached with end-to-end waveguide separations between the two adjacent waveguides of 175 nm for three strips, four strips and five strips inserted between two photonic waveguides. Achieving a coupling length of 104110 µm proves that the proposed design is better than previously proposed designs in terms of coupling length. In addition, we have compared the coupling lengths obtained when Ge strips and Si strips were inserted between the photonic waveguides. The method given in this paper can be used to design a variety of photonic applications.
Advanced Drug Delivery of Paclitaxel with Thermoresponsive Water-soluble Micelles for Ovarian Cancer
Authors: Shin Ueon sang , Kang Ji-Hye , Hwang Ji-Young , Cho Young-Jae , Park Sang-Yu , Choi Jung-Joo , Paik E-Sun , Lee Jeong-Won 
Published: September 2022

Abstract
As an anti-cancer drug, paclitaxel (PTX) is known to be effective for treating patients with ovarian cancer. Not only do dose density and side effects of PTX represent a certain difficulty in chemotherapy, but also cause problems related to its poor water solubility during the administration. From the dose-density concept, we hypothesized that continuous release of PTX could increase the duration of exposure to tumor cells and may be an effective ovarian cancer treatment for patients. Herein, we developed highly water-soluble and multi-temperature-responsive PTX delivery systems to treat ovarian cancer. This was accomplished by entrapping the hydrophobic PTX in poly(NIPAAm-co-BVIm) micelles engineered to deliver drugs (pNIB/PTX). Specifically, the pNIB/PTX-3 complex containing 74 μg PTX loaded at 25 °C showed a rapid release of PTX initially (5.9 %/day) during the first five days at 37 °C. The release rates decreased (1.1 %/day) over the following month, indicating a multi-step release. In orthotopic ovarian cancer mouse models, the pNIB/PTX complex resulted in a six-fold greater therapeutic effect with a single intraperitoneal injection than weekly PTX treatment alone in vitro using two human ovarian cancer cell lines, HeyA8 and SKOV3ip. Moreover, the tumor weights in HeyA8 and SKOV3ip1 models were remarkably decreased with the pNIB/PTX complex compared to the controls. The good water solubility and temperature-dependent release of PTX carriers are highly effective for short-term and long-term delivery. This multi-step drug delivery may be used as a potential candidate for the treatment of patients with ovarian cancer.
Antibiotic Resistance in Respiratory Bacterial Isolates From Critical Care Patients Infected With Sars-CoV2
Authors: BENEDETTI PAOLO , PEGORARO MANUELA , NOVELLO ELENA , ROMUALDI CHIARA , MANFRIN VINICIO , LIVERMORE DAVID MARTIN 
Published: September 2022

Abstract
Purpose. Although secondary bacterial infections are uncommon in COVID-19, ventilator pneumonia is a hazard. We undertook a retrospective, observational study at an ICU in Vicenza, Italy, comparing pulmonary bacterial isolates between COVID-19 and non-COVID-19 patients.Methods. Respiratory bacteria were recovered from: (i) ICU patients admitted in Feb-May 2019, pre-pandemic; (ii) ICU patients admitted with COVID-19 during the first (Feb-May 2020) wave and (iii) non-COVID-19 ICU patients from Feb-May 2020. Results. We reviewed 120 patients, 61 in the control (2019) group and 59 (28 COVID-19 and 31 non-COVID-19) from 2020. Two hundred isolates were grown: 101 from the 2019 control patients, 42 from the 2020 COVID-19 patients and 57 from the 2020 non-COVID patients. Enterobacterales dominated throughout but Pseudomonas aeruginosa was significantly (p <0.01) more prevalent in COVID-19 than non-COVID patients and MDR P. aeruginosa (3/12; 25%) were exclusively found in COVID-19 patients. Other critical resistance types (MRSA, ESBL- and carbapenemase-producing Enterobacterales) were rare, without significant differences in prevalence between groups. ICU and hospital mortality were greater among COVID-19 than non-COVID patients. Deaths occurred in 6/9 COVID patients (66.7%) who did not receive targeted antibiotic therapy despite microbiological diagnosis.Conclusion. These data underscore the importance of secondary bacterial pathogens in ICU COVID patients and the threat of antibiotic inadequacy favouring poor outcomes in VAP. The organisms found in COVID patients were typical of VAP, though P. aeruginosa was more prominent.
The addition of ROTEM parameter did not significantly improve the massive transfusion prediction in severe trauma patients
Authors: Baik Dongyup , Yeom Seok-Ran , Park Sung-Wook , Cho Youngmo , Yang Wook Tae , Kwon Hoon , Lee Jae Il , Ko Jun-Kyeung , Choi Hyuk Jin , Huh Up , Goh Tae Sik , Song Chan-Hee , Hwangbo Lee , Wang Il Jae 
Published: September 2022

Abstract
ObjectiveThis study aimed to assess whether rotational thermoelectrometry (ROTEM) data could improve the massive transfusion (MT) prediction model.MethodThis was a single-center, retrospective study. Patients who presented to the trauma center and underwent ROTEM between 2016 and 2020 were included. The primary and secondary outcomes were massive transfusion and in-hospital mortality, respectively. We constructed two models using multivariate logistic regression with backward conditional stepwise elimination (Model 1: without ROTEM parameter and Model 2: with ROTEM parameters). The area under the receiver operating characteristic curve (AUROC) was calculated to assess the predictive ability of the models.ResultIn total, 969 patients were included; 196 (20.2%) received MT. The in-hospital mortality rate was 14.1%. For MT, the AUROC was 0.854 (95% confidence interval [CI], 0.825-0.883) and 0.860 (95% CI, 0.832-0.888) for Model 1 and 2, respectively. For in-hospital mortality, the AUROC was 0.886 (95% CI, 0.857-0.915) and 0.889 (95% CI, 0.861-0.918) for Model 1 and 2, respectively. The AUROC values for Models 1 and 2 were not statistically different for either MT or in-hospital mortality.ConclusionWe found that addition of the ROTEM parameter did not significantly improve the predictive power of MT and in-hospital mortality in trauma patients.
Activation of Arcuate nucleus Glucagon-like Peptide-1 receptor-expressing neurons suppresses food intake
Authors: Singh Ishnoor , Wang Le , Xia Baijuan , Liu Ji , Tahiri Azeddine , Ouaamari Abdelfattah El , Wheeler Michael B. , Pang Zhiping P. 
Published: September 2022

Abstract
BackgroundCentral nervous system (CNS) control of metabolism plays a pivotal role in maintaining energy balance. In the brain, Glucagon-like peptide 1 (GLP-1), encoded by the proglucagon ‘Gcg’ gene, produced in a distinct population of neurons in the nucleus tractus solitarius (NTS), has been shown to regulate feeding behavior leading to the suppression of appetite. However, neuronal networks that mediate endogenous GLP-1 action in the CNS on feeding and energy balance are not well understood. This is mainly due to the presence of diverse neuronal subtypes and complex central neuronal connectivity. Results We systematically analyzed the distribution of GLP-1R-expressing neurons and axonal projections of NTSGcg proglucagon expressing neurons in the mouse brain. GLP-1R neurons were found to be broadly distributed in the brain and specific forebrain regions, particularly the hypothalamus, including the arcuate nucleus of the hypothalamus (ARC), received dense NTSGcg neuronal projections. For this reason, the impact of GLP-1 signaling in the ARC, a brain region known to regulate energy homeostasis and feeding behavior was examined. Application of GLP-1R specific agonist Exendin-4 (Exn-4) enhanced the ARC pro-opiomelanocortin (POMC) neuronal population’s action potential firing frequency and miniature excitatory postsynaptic spontaneous currents amplitude. Using a chemogenetic approach to activate the ARC GLP-1R neurons by using Cre-dependent hM3Dq AAV in the GLP-1R-ires-Cre mice, we established that acute activation of the ARC GLP-1R neurons significantly suppressed food intake but did not affect glucose homeostasis. ConclusionsThese results highlight the importance of central GLP-1 signaling and in particular neurons within the ARC that express GLP-1R that upon activation, regulate feeding behavior.
Unilateral Acute Lung Injury in Pig: A Promising Animal Model
Authors: Geilen Johannes , Kainz Matthias , Zapletal Bernhard , Geleff Silvana , Wisser Wilfried , Bohle Barbara , Schweiger Thomas , Schultz Marcus J. , Tschernko Edda 
Published: September 2022

Abstract
Background
Acute lung injury (ALI) occurs in 23% unilateral. Models of unilateral ALI were developed and used previously without clearly demonstrating the strictly unilateral nature and severity of lung injury by the key parameters characterizing ALI as defined by the American Thoracic Society (ATS). Thus, the use of unilateral ALI remained rare despite the innovative approach. Therefore, we developed a unilateral model of ALI and focused on the crucial parameters characterizing ALI. This model can serve for direct comparisons between the injured and intact lungs within single animals, thus, reducing the number of animals required for valid experimental conclusions.
Methods
We established the model in nine pigs, followed by an evaluation of key parameters in six pigs (main study). Pigs were ventilated using an adapted left double-lumen tube for lung separation and two ventilators. ALI was induced in the left lung with cyclic rinsing (NaCl 0.9%+Triton® X-100), after which pigs were ventilated for different time spans to test for the timing of ALI onset. Ventilatory and metabolic parameters were evaluated, and bronchoalveolar lavage (BAL) was performed for measurements of inflammatory mediators. Finally, histopathological specimens were collected and examined in respect of characteristics defining the lung injury score (LIS) as suggested by the ATS.
Results
After adjustments of the model (n = 9) we were able to induce strictly left unilateral ALI in all six pigs of the evaluation study. The median lung injury score was 0.72 (IQR 0.62–0.79) in the left lung vs 0.14 (IQR 0.14–0.16; p < 0.05) in the right lung, confirming unilateral ALI. A significant and sustained drop in pulmonary compliance (Cdyn) of the left lung occurred immediately, whereas Cdyn of the right lung remained unchanged (p < 0.05). BAL fluid concentrations of interleukin-6 and − 8 were increased in both lungs.
Conclusions
We established a model of unilateral ALI in pigs, confirmed by histopathology, and typical changes in respiratory mechanics and an inflammatory response. This thoroughly evaluated model could serve as a basis for future studies and for comparing pathophysiological and pharmacological changes in the uninjured and injured lung within the same animal.