bluuebunny/crossref_metadata_2025_split huggingface dataset:
Methodological Verification-based Screening of the Representative Ingredients for Traditional Chinese Medicine: Taking Astragalus as an Example for Interfering with Cervical Cancer
Authors: Sun Hao , Wang Dan , Xu Mengjin , Gao Yi , Li Fan 
Published: August 2022

Background:The screening of effective ingredients is the bridge between the research of efficacy and the mechanism of traditional Chinese medicine. Although promising virtual screening has emerged as an attractive alternative, an ideal strategy is still urgently required due to the characteristics of multi-ingredients and multi-targets of traditional Chinese medicine.Objective:The aim of the study was to develop a methodological verification-based novel screening strategy capable of comprehensively assessing the ability of compounds to perturb disease networks, thereby identifying representative ingredients of traditional Chinese medicine interventions in complex diseases.Methods:In this article, we take astragalus interfering with cervical cancer as an example. First, a multifunctional clustering disease network model was constructed; second, the several drugs and their decoys were used for molecular docking with disease network clusters for methodological verification and determining the best scoring criteria. Third, the representative ingredients of astragalus were screened according to the best scoring criteria. Finally, the effects of the representative ingredients on cervical cancer SiHa cells were evaluated by CCK-8 assay, flow cytometry, and western blot analysis.Results:Three representative ingredients of astragalus were betulinic acid, hederagenin and methylnissolin, which perturbed the apoptosis, stabilization of p53, and G1/S transition cluster as a whole, respectively. CCK-8 assay showed that the IC50 value of betulinic acid, hederagenin and methylnissolin at 48 h was 28.84, 101.90, and 187.40 μM, respectively. Flow cytometry showed that these three representative ingredients could significantly induce early apoptosis and cell cycle arrest. Western blot analysis showed that betulinic acid treatment significantly increased p53 expression, while hederagenin and methylnissolin did not.Conclusions:This study has provided new ideas for the screening of effective ingredients in traditional Chinese medicine, and established a foundation for elucidating the overall mechanism of action of traditional Chinese medicine
Managing Power Flow in Hybrid Electric Vehicle with Auxiliary Hybrid
Energy Source coupled with Bidirectional Converter Using PI Control
Authors: Srivastava Swapnil , Yadav Kanchan , Maurya Sanjay Kumar 
Published: August 2022

Background:
The overall performance of the hybrid electric vehicle is mainly governed by the energy storage systems characteristics with respect to their power and energy density. The batteries have a good energy density, while the supercapacitor (SC) has a good power density.

Method:
This paper presents a hybrid auxiliary source combined with a battery and the supercapacitor to use both characteristics of auxiliary energy source for Hybrid Electric Vehicle (HEV) application. The PI control technique is used for managing the power flow so that the supercapacitor fulfills the transient power and the battery supplies the steady-state power. The parameters of controllers are tuned by Ziegler Nichols and frequency response-based method.

Result:
The performance of the controller is evaluated by error coefficients (IAE, ISE, ITAE and ITSE). The model with different tuning parameters is simulated for fixed and variable reference inputs. The speed, dc bus voltage, and error coefficients are evaluated for the battery alone and battery-SC combinations.

Conclusion:
The value of error-based parameters suggests that controller parameters tuned by the frequency response-based method provide better results. The error coefficients for battery-supercapacitor combination are lower as compared to battery-alone systems indicating the better performance of hybrid input.
Research Progress on Improving the Stability of Paraffin Emulsion:
A Mini-Review
Authors: Liang Yu , Xia Endong , Li Haiyan , Wang Zidong , Ma Shoutao 
Published: August 2022

Abstract:
Paraffin emulsion is a highly dispersed, thermodynamically unstable system.
Emulsifiers play a key role in promoting emulsion formation and improving emulsion
stability. However, a single emulsifier has limitations in maintaining emulsion stability,
usually, it is necessary to compound more than two emulsifiers or add other additives to
make the paraffin emulsion have better stability. Therefore, how to keep paraffin emulsion high dispersibility and stability for a long time are the problems that the majority of
researchers have been concerned about. This paper expounded the instability mechanism
of paraffin wax emulsion. The process of paraffin emulsion destabilization is the process
of gradually reducing the free energy of the system and the interaction force between
emulsion droplets determines the speed of emulsion destabilization. Sedimentation and
stratification, flocculation, coalescence, and Ostwald Ripening were the main factors
leading to paraffin instability; the prevention and improvement methods are proposed for
the above four mechanisms. From the instability mechanism, the factors affecting the
stability of paraffin emulsion mainly include the mechanical strength and film elasticity
of the interface film, the interfacial charge or obstruction between the emulsion droplets,
the appropriate system viscosity, and the uniform droplet size distribution will affect the
stability of the paraffin emulsion. Through literature research, several methods to improve the stability of paraffin emulsion were summarized. Polar paraffin has good emulsifying properties, compounding with paraffin can not only reduce the amount of emulsifier but also enhance the stability of paraffin emulsion, adding thickeners can reduce the
Brownian motion of droplets and improve the chemical and mechanical stability of wax
emulsions, the addition of ionic surfactants can reduce the diffusion rate of the dispersed
phase, the addition of inorganic salts can make the emulsion droplets generate strong repulsion when they are close to each other, and improve the stability of the emulsion, the
addition of small molecular alcohols can improve the flexibility of the oil-water interface
film properties, reduce the surface tension coefficient of the emulsion, and increase the
stability of the paraffin emulsion. This paper can provide a theoretical reference for the
research on the stability of paraffin emulsion.
Trends in Health Quality–Related Publications Over the Past Three Decades: Systematic Review
Authors: Mendlovic Joseph , Mimouni Francis B , Arad Iris , Heiman Eyal 
Published: August 2022

Background
Quality assessment in health care is a process of planned activities with the ultimate goal of achieving a continuous improvement of medical care through the evaluation of structure, process, and outcome measures. Physicians and health care specialists involved with quality issues are faced with an enormous and nearly always increasing amount of literature to read and integrate. Nevertheless, the novelty and quality of these articles (in terms of evidence-based medicine) has not been systematically assessed and described.

Objective
The objective of this study was to test the hypothesis that the number of high-evidence journal articles (according to the pyramid of evidence), such as randomized control trials, systematic reviews, and ultimately, practice guidelines, increases over time, relative to lower-evidence journal articles, such as editorials, reviews, and letters to the editors.

Methods
We used PubMed database to retrieve relevant articles published during the 31-year period between January 1, 1989, and December 31, 2021. The search was conducted in April 2022. We used the keywords “quality care,” “quality management,” “quality indicators,” and “quality improvement” and limited the search fields to title and abstract in order to limit our search results to articles nearly exclusively related to health care quality.

Results
During this 31-year evaluation period, there was a significant cubic increase in the total number of publications, reviews, clinical trials (peaking in 2017, with a sharp decline until 2021), controlled trials (peaking in 2016, with a sharp drop until 2021), randomized controlled trials (peaking in 2017, with a sharp drop until 2021), systematic reviews (nearly nonexistent in the 1980s through 1990s to a peak of 222 in 2021), and meta-analyses (from nearly none in the 1980s through 1990s to a peak of approximately 40 per year in 2020). There was a linear increase in practice guidelines from none during 1989-1991 to approximately 25 per year during 2019-2021, including a cubic increase in editorials, peaking in 2021 at 125 per year, and in letters to the editor, peaking at 50-78 per year in the last 4 years (ie, 2018-2021).

Conclusions
Over the past 31 years, the field of quality in health care has seen a significant yearly increase of published original studies with a relative stagnation since 2015. We suggest that contributors to this dynamic field of research should focus on producing more evidence-based publications and guidelines.
User Behavior of a Publicly Available, Free-to-Use, Self-guided mHealth App for Depression: Observational Study in a Global Sample
Authors: Su Langting , Anderson Page Lyn 
Published: August 2022

Background
Reducing the burden of depression is a global health concern. Self-guided mobile health (mHealth) apps are one approach to address this problem. However, there is little research on self-guided mHealth apps in a global sample or on how they are used in the real world. These gaps in our knowledge must be addressed to bring the promise of mHealth apps for reducing the global burden of depression closer to reality.

Objective
The purpose of this study is to examine the naturalistic user behavior of MoodTools, a publicly available, free-to-use, self-guided mHealth app designed to improve symptoms of depression, in a global community sample.

Methods
Mobile analytics data were collected from all unique downloads of the Android version of MoodTools between March 1, 2016, and February 28, 2018. Due to the deidentification and data aggregation process, no demographic or personal identifying information was tied to individual user data. All information was stored in aggregated, anonymized data files on Google Analytics’ storage database. Google’s software development kit was used to securely capture data about the number of downloads, location of downloads, number of app sessions, frequency and duration of app sessions, time between app sessions, and user retention, allowing for examination of which app’s tools were viewed and for how long, including Information (psychoeducation), Test (self-monitoring using the Patient Health Questionnaire [PHQ-9]), Thought Diary (targeting negative cognitions), Activities (behavioral activation), Videos (curated from YouTube), and Safety Plan (safety plan development and links to quickly access crisis management resources).

Results
MoodTools was used by 158,930 people from 198 countries, including countries where English was not the primary language and in low- and middle-income countries. After the initial download, 51.14% (n=81,277) of users returned to the app after the initial download, and retention rates decreased with each subsequent app session. The typical person used the app for 3 sessions for a total of 12 minutes over 90 days. The most frequently visited tools were Test and Thought Diary (n=393,549, 24.32%). On average, users completed and reviewed the results of the PHQ-9 for 49 seconds and 53 seconds, respectively, and spent 3 minutes and 5 seconds on Thought Diary.

Conclusions
Self-guided mHealth apps could be one approach (among the many needed) to reduce the burden of depression. Observational data collected in this study show a global interest in MoodTools, including in low- and middle-income countries and countries where English is not the primary language. Future research is needed to determine whether people who use self-guided apps experience improvement in depressive symptoms, and if so, what “dosage” provides a meaningful benefit.
Una caminata por el libro-galería: Nueve pintores mexicanos de Juan García Ponce. Imagen autoral y trabajo colaborativo
Authors: Castillo Cadenas Mildred 
Published: August 2022

A partir de la metáfora del libro como galería, el presente texto hace un recorrido por Nueve pintores mexicanos (1968) de Juan García Ponce. Mediante la noción de caminata de Rebecca Solnit (2000), la propuesta es entrar y salir del ejemplar con base en la experiencia de leer y ver al mismo tiempo. Esto da pie a observar cómo, al reunir textos de crítica de arte y una colección de pintura y fotografía, los implicados produjeron una imagen de autor individual y de grupo a través de la publicación. Dicha cuestión se vincula al análisis de su trabajo colaborativo, como parte de un momento sugerente para la cultura del libro durante la segunda mitad del siglo xx en México. Así, el texto explora la relación creativa que se gestó entre García Ponce, el fotógrafo Héctor García y los nueve pintores de la llamada Ruptura: Lilia Carrillo, Manuel Felguérez, Fernando García Ponce, Francisco Corzas, Gabriel Ramírez, Roger von Gunten, Arnaldo Coen, Alberto Gironella y Vicente Rojo. También se aborda el contexto histórico, político y social de 1968, en cuanto escenario de suma importancia para la configuración discursiva, autoral y visual del libro. Asimismo, el texto se divide en apartados que se aproximan a aspectos de la publicación no necesariamente cronológicos.
Effect of Price and Service Quality on Customer Satisfaction and Its Implications on Customer Loyalty PT. XYZ
Authors: Haryanto Rahmat , Sitio Arifin 
Published: August 2022

ABSTRACT This study aims to analyze the Effect of Price and Service Quality on Customer Satisfaction and Its Implications on the Customer Loyalty of PT. XYZ This type of research used in this study is Causal Research Type. The population in this study were all patients who had visited and had received health services at PT. XYZ in 2018 as many as 43,476 people. Determination of the number of samples using the formula Slovin so as to get 100 respondents. The analysis method used is the regression analysis test through SPSS version 25. The results of this study indicate that (1) Price has a positive and significant effect on patient satisfaction, (2) Service Quality has a positive and significant effect on Patient Satisfaction, (3) Price influences positive and significant impact on Patient Loyalty, (4) Service Quality has positive and significant impact on Patient Loyalty, (5) Patient Satisfaction has positive and significant impact on Patient Loyalty, and (6) There is a positive indirect effect between Price and Quality of Service on loyalty through patient satisfaction, meaning through patient satisfaction can increase patient loyalty.
GOVERNO BOLSONARO, UM GOVERNO FUNDADO EM FAKE NEWS?
Authors: Morais Marcelo Maurício de 
Published: August 2022

O presente artigo pretende discutir sobre as fakes news produzidas, disseminadas e impulsionadas dentro do governo bolsonarista. Trata-se não de apontar o governo bolsonarista como criador dessas notícias falsas, mas apurar como esse tipo de notícia tem ocorrido frequentemente nesse período. O artigo está dividido em duas partes: na primeira identificaremos qual tipo de fake news se verifica tentando categorizar essas notícias falsas propagadas dentro do governo bolsonarista de acordo com estudiosos e pesquisadores da área. A segunda parte está dedicada a análise das próprias fakes news identificando os alvos dessas notícias falas e suas repercussões. A metodologia e técnicas de pesquisa se concentraram em: a) Identificar “notícias falsas” e seus autores, através de categorias pré-definidas por outros estudiosos que possam auxiliar na identificação das “notícias falsas” disseminadas “dentro do governo”, a partir de então trabalharmos com a definição já conceituada anteriormente por pesquisadores da área; b) Os instrumentos utilizados para a coleta de dados e informações que serviram para realização da pesquisa foram extraídas de matérias jornalísticas de veículos tradicionais de comunicação, tanto, quanto de pesquisas realizadas por instituições de excelência como Reuters Institute Digital News Report e DataSenado instituo de pesquisas do Congresso Nacional Brasileiro. E por fim os resultados encontrados apresentam-se como uma complexa relação entre governo e segmentos da sociedade que promoveram notícias falsas produzidas por apoiadores, parlamentares e membros do governo Bolsonaro publicados em suas redes sociais e confirmados sua falsidade por agências de Fact-checking com a Agência Lupa seguida de rigorosa análise política.
Current issues of legal regulation of abortions in Ukraine
Authors: Bilich D. 
Published: August 2022

The article is devoted to the main issues related to the realization of the right to life of the unborn child, as well as the mother’s right to self-determination regarding the ability to dispose of her body. The question of the moment of the beginning of the child’s life is also investigated. In determining the moment of the beginning of life, the author distinguished between the concepts of “embryo” and “fetus”.
The urgency of the work in connection with the constant discussions and debates that take place among scientists, lawmakers, physicians and biologists not only in Ukraine but at the global level is analyzed.
Pro life and pro choice approaches to determining the beginning of a person’s life are considered. The division of states is indicated, depending on the legislative permission for abortion, as well as social, economic and medical indicators. The urgency of the work in connection with the beginning of Russian aggression and occupation of Ukrainian lands.
Ukrainian legislation, relevant provisions of the Civil Code, draft laws of Ukraine, which were submitted for consideration but did not enter into force, as well as the position of the European Court of Human Rights on the right to life for the embryo were analyzed.
Opinions and statements of foreign scientists on the possibility of a mother to decide the future of her child in the womb are given. The division of states is indicated, depending on the legislative permission for abortion, as well as social, economic and medical indicators.
A look at the problem that determines the beginning of a person’s life is fertilization, it’s not birthday of a child .
The possibility of amending the Constitution of Ukraine and arguing the need for these changes in Ukrainian legislation to further determine the exact beginning of human life and eliminate legislative conflicts are considered.
Problematik aspects of protection of constitutional human rights in Ukraine and ways to overcome them
Authors: Kravchuk S. 
Published: August 2022

The article reveals the problematic aspects of the state of protection of human and civil rights in Ukraine, as such rights are the basis for the existence of the state as a subject of international law. Today, respect for human and civil rights and freedoms -the main criterion of civilized society, its ability to solve the most complex economic, political and social problems. It is no coincidence that the international community seeks to treat human rights globally, on an equitable and equal basis. This takes into account the national and regional specifics of states, their various historical, cultural and religious features.
The article aims at a comprehensive solution to the organization of the legal system of human rights protection, which must comply with international and national law. This provides a legal description and identifies elements of a set of guarantees for constitutional protection of rights, taking into account national experience, case law, experience of other states, as well as international standards in the field of human and civil rights, generalization and development of ideas on this issue social space.
Modern Ukrainian society is going through a stage of deep awareness of human rights and freedoms, which can be seen as the beginning of the spiritual revival of Ukraine. The very ideology of rights is becoming more widely recognized and in demand in state and public life. From the point of view of this ideology, there is a reassessment of views on the Soviet and post-Soviet past and a projection on the near and distant future of Ukraine.
Implementation in practice of protection and defense of human and civil rights and freedoms is a long and gradual process of transformation of the whole society. However, this process has certain time limits set by the Association Agreement between Ukraine and the European Union. The implementation of this Agreement requires not only appropriate measures to improve the quality of legislation in this area, improve the executive and judiciary, local governments, and increase the activity of citizens in the context of exercising the right to protect their rights and freedoms in all ways not prohibited by law.
The goal set in the article was achieved by solving the problems of studying the constitutional features of the organization of such protection and its implementation in practice.
Reform of legal regulation of intellectual property in the conditions of European integration
Authors: Pypіak M. , Koval A. , Kolesyuk D. 
Published: August 2022

The article examines the legal basis for the protection of intellectual property rights in the EU and in Ukraine. The main aspects of the development of intellectual property rights in Ukraine in accordance with EU requirements have been identified. The analysis of the basic normative-legal acts in the certain sphere is carried out. The nearest prospects of further development of the domestic legislation in the field of protection of the intellectual property right are outlined. The task of creating conditions for proper and effective protection of intellectual property rights in Ukraine is analyzed.
EU law is a unique independent legal system that develops slightly differently than the legal systems of individual states that are integrated into it, other than the system of international law, which provides fruitful ideas for the development of European law. That is why it seems quite interesting to study the branches of the EU legal system, which is based on the «constitutional» ideas of a new, supranational nature. The EU’s integration law, which has been formed for more than half a century, represents a complex set of legal instruments regulating and directing the processes of comprehensive integration carried out within the European legal space. Eu enlargement processes lead to the fact that its harmonized and unified law gradually and naturally, directly and indirectly, affects the legal systems of European countries. The right to «truly invok» the new galuzz of the law of the US, so it remains an hour to allow the «intensively to realize» that in the same way the legal pre-member of the Region in the spheres of legal life is still in the area. for the same standards of law, the buli is an important official to the bottling of the national legality of the real rights.
I look at those who voted in one of the strategic areas. the beginning of the adaptation of the adaptation of the law of Ukraine to the legality of the «S» in the spheres of the «intellectual» ‘The yaku z Viconanny’s mzhnarny gobov’yazan Ukraine that zadda gusda about the partnership that spivrobnittvo in Ukraine EU.