bluuebunny/crossref_metadata_2025_split huggingface dataset:
Oestrogen ameliorates blood-brain barrier damage after experimental subarachnoid haemorrhage via the SHH pathway in male rats
Authors: Zhang Jie , Li Haiying , Xu Zhongmou , Lu Jinxin , Cao Chang , Shen Haitao , Li Xiang , You Wanchun , Chen Gang 
Published: December 2022

BackgroundSex differences affect the occurrence, progression and regression of subarachnoid haemorrhage (SAH). Oestrogen plays a protective role in alleviating the vasospasm and neuronal apoptosis induced by SAH. However, whether oestrogen affects blood‒brain barrier (BBB) integrity has not been fully studied. Oestrogen has been found to regulate the sonic hedgehog (SHH) signalling pathway through the oestrogen receptor in gastric cancer and adrenal glands, and the SHH signalling pathway has an important role in maintaining the BBB by upregulating the expression of tight junction proteins. In this study, we investigated the relationship between oestrogen and the SHH signalling pathway using clinical data and established an experimental SAH model to explore whether oestrogen could ameliorate BBB damage after SAH through the SHH pathway.MethodsCorrelations between oestrogen and the SHH pathway were analysed by patients’ cerebrospinal fluid (CSF) samples and the Genotype-Tissue Expression database (GTEx). Then, an experimental rat SAH model was established using the endovascular perforation method and treated with oestrogen, oestrogen inhibitors and SHH signalling pathway inhibitors. Then, the effects of oestrogen on BBB damage were analysed by western blot, immunofluorescence and neurobehavioural experiments.ResultsESLIA detection and correlation analysis showed that oestrogen levels in patients’ CSF were positively correlated with the SHH pathway, which was further verified by GTEx gene-correlation analysis. SHH was found to be mainly expressed in neurons and astrocytes in rats under physiological conditions and was upregulated by oestrogen pretreatment. In the SAH model, oestrogen pretreatment was found to reverse SAH-induced decreases in the SHH pathway, which were counteracted by oestrogen receptor inhibitors. Furthermore, oestrogen pretreatment reduced SAH-induced BBB damage, brain oedema and neurological dysfunction, which were eliminated by SHH pathway inhibitors.ConclusionIn conclusion, we demonstrate here that oestrogen pretreatment ameliorates brain injury after SAH, at least in part through SHH pathway-mediated BBB protection.
Capacidades dinâmicas e turismo: uma análise bibliométrica
Authors: Barbosa Amanda de Paula Aguiar , Fischmann Adalberto Américo 
Published: December 2022

O presente artigo objetiva analisar as redes bibliométricas sobre a pesquisa em capacidades dinâmicas que estão relacionadas ao turismo, identificando novas tendências que estão surgindo na área, bem como os temas que estão consolidados nesse campo de estudo. Trata-se de uma meta-análise qualitativa e exploratória que sistematiza a análise de 384 artigos científicos publicados entre janeiro de 1995 e junho de 2021. O uso da meta-análise se justifica pela utilização de técnicas de mapeamento e clusterização das redes bibliométricas, feitas a partir do software Vosviewer. Os resultados apresentam os elementos centrais nas redes sociais de pesquisadores e nos temas relacionados à pesquisa sobre capacidades dinâmicas no turismo, bem como evidenciam a formação de cinco clusters principais que representam cinco focos de análise: impactos e sustentabilidade (cluster 1); clusters e capacidade absortiva (cluster 2); planejamento estratégico (cluster 3); tecnologia e inovação (cluster 4); e coopetição (cluster 5).
“El calor como colmillo de jabalí”: los momentos de llegada del inmigrante entre experiencia histórica y dimensión poética en Migraciones de Gloria Gervitz
Authors: Dolle Verena 
Published: December 2022

Os momentos de chegada dos imigrantes à terra que os recebe são momentos clichês frequentemente descritos nos textos (auto-)biográficos de autores mexicanos de origem ashkenazi: eles descrevem, ou melhor, imaginam a chegada de seus pais ou avós que cruzaram uma fronteira cultural e linguística e pisaram em solo mexicano, por exemplo. M. Glantz, Las genealogias (1981), S. Berman, La bobe (1990), J. Woldenberg, Las presencias ausentes (1992) e I. Stavans, On Borrowed Words (2001). Percebe-se que essa chegada tem as características de uma narrativa fundante para os escritores das gerações posteriores que, por meio dela, dão sentido ao processo imigratório e à localização de seus antecessores e de si mesmos na cultura e no mundo mexicano.
Meu artigo tem como objetivo investigar a complexa relação que se desenrola na coletânea de poemas Migraciones (1976-2016) da autora judia mexicana Gloria Gervitz, onde essa cena fundadora oscila entre a experiência histórica corpórea e concreta de pisar a terra e a dimensão poética.
Reduced Access to Preventive Care Due to the COVID-19 Pandemic, by Chronic Disease Status and Race and Hispanic Origin, United States, 2020-2021
Authors: Irimata Katherine E. , Pleis John R. , Heslin Kevin C. , He Yulei 
Published: December 2022

Objectives: The COVID-19 pandemic has disproportionately affected racial and ethnic minority populations in the United States. The National Center for Health Statistics adapted the Research and Development Survey (RANDS), a commercial panel survey, to track selected health outcomes during the pandemic using the series RANDS during COVID-19 (RC-19). We examined access to preventive care among adults by chronic condition status, race, and Hispanic origin. Methods: NORC at the University of Chicago conducted RC-19 among US adults in 3 rounds (June–July 2020 [round 1, N = 6800], August 2020 [round 2, N = 5981], and May–June 2021 [round 3, N = 5458]) via online survey and telephone. We evaluated reduced access to ≥1 type of preventive care due to the pandemic in the past 2 months for each round by using logistic regression analysis stratified by chronic condition status and race and Hispanic origin, adjusting for sociodemographic and health variables. Results: Overall, 35.8% of US adults reported missing ≥1 type of preventive care in the previous 2 months in round 1, 26.0% in round 2, and 11.2% in round 3. Reduced access to preventive care was significantly higher among adults with ≥1 chronic condition (vs no chronic conditions) in rounds 1 and 2 (adjusted odds ratios [aOR)] = 1.5 and 1.4, respectively). Compared with non-Hispanic White adults, non-Hispanic Black adults reported significantly lower reduced access to preventive care in round 1 (aOR = 0.7), and non-Hispanic Other adults reported significantly higher reduced access to preventive care in round 2 (aOR = 1.5). Conclusions: Our findings may inform policies and programs for people at risk of reduced access to preventive care.
Palliative care for people who use drugs during communicable disease epidemics and pandemics: A scoping review on access, policies, and programs and guidelines
Authors: Buchman Daniel Z , Lo Samantha , Ding Philip , Dosani Naheed , Fazelzad Rouhi , Furlan Andrea D , Isenberg Sarina R , Spithoff Sheryl , Tedesco Alissa , Zimmermann Camilla , Lau Jenny 
Published: December 2022

Background: People who use drugs with life-limiting illnesses experience substantial barriers to accessing palliative care. Demand for palliative care is expected to increase during communicable disease epidemics and pandemics. Understanding how epidemics and pandemics affect palliative care for people who use drugs is important from a service delivery perspective and for reducing population health inequities. Aim: To explore what is known about communicable disease epidemics and pandemics, palliative care, and people who use drugs. Design: Scoping review. Data sources: We searched six bibliographic databases from inception to April 2021 as well as the grey literature. We included English and French records about palliative care access, programs, and policies and guidelines for people ⩾18 years old who use drugs during communicable disease epidemics and pandemics. Results: Forty-four articles were included in our analysis. We identified limited knowledge about palliative care for people who use drugs during epidemics and pandemics other than HIV/AIDS. Through our thematic synthesis of the records, we generated the following themes: enablers and barriers to access, organizational barriers, structural inequity, access to opioids and other psychoactive substances, and stigma. Conclusions: Our findings underscore the need for further research about how best to provide palliative care for people who use drugs during epidemics and pandemics. We suggest four ways that health systems can be better prepared to help alleviate the structural barriers that limit access as well as support the provision of high-quality palliative care during future epidemics and pandemics.
Inverted Thoracic Stent Graft Technique for Separation of a Stent Graft and Bare Stent Caused by Aortic Elongation
Authors: Matsumoto Ryumon , Nishi Satoshi , Yoshimoto Akihiro , Suematsu Yoshihiro 
Published: December 2022

Introduction Component separation (CS) of the Zenith Dissection Endovascular Graft and Stent have been reported with some causes. However, CS caused by aortic elongation has not yet been reported. A long treatment range with the sacrifice of some intercostal arteries (ICAs) is sometimes needed when repairing CS because of the large difference in the diameter between the proximal and distal landing zones with a reverse taper. Case presentation A 78-year-old man, who underwent thoracic endovascular aortic repair (TEVAR) using a Zenith Dissection Graft and stents for acute type B aortic dissection 3 years and 8 months previously was admitted to our hospital with severe back pain. Contrast-enhanced computed tomography (CT) showed separation of the SG and bare stent, and aortic elongation. As there was a large difference in the diameter of the proximal and distal landing zones with a reverse taper, a long treatment range with the sacrifice of two large ICAs was needed. Thus, TEVAR using an inverted thoracic SG technique was performed in order to shorten the treatment range to preserve a large ICA and reduce the risk of paraplegia. Completion angiography showed that the separation was repaired with preservation of the large ICA. The postoperative course was uneventful, and he was discharged on postoperative day 10 with relief of his severe pain. At 1 year after secondary TEVAR, CT showed that the diameter of the descending aorta had decreased with no separation of the SGs. Conclusion Deployment of an inverted thoracic SG for the treatment of CS of the Zenith Dissection Endovascular Graft and Stent is a feasible and effective procedure to preserve ICAs. An overlapping range of >1.5 times the length of a bare stent within an SG is needed to prevent CS of the Zenith Dissection Endovascular Graft and Stent caused by aortic elongation.
Usefulness of cone-beam computed tomography to predict residual stenosis after carotid artery stenting
Authors: Roh Jieun , Baik Seung Kug , Yeom Jeong A , Park Kyung-Pil , Ahn Sung-Ho , Park Min-Gyu 
Published: December 2022

Objectives The long-term durability of carotid artery stenting (CAS) may be determined by various factors; however, residual stenosis is a known risk factor for in-stent restenosis. The authors of this article utilized cone-beam computed tomography (CBCT) in angiosuite to investigate plaque features affecting the character and quality of stent expansion after CAS. Methods Forty-two CAS cases with both pre- and post-CAS CBCT evaluations were included in this retrospective analysis. Five features derived from pre-CAS images were tested: (1) eccentricity, (2) overballoon, (3) maximum plaque thickness, (4) calcification barrier, and (5) stenotic degree. For post-CAS CBCT, stent configuration was assessed if the stent was expanded and oval or round in shape as well as outward or inward in orientation. Variables were tested if they were associated with oval expansion, outward expansion, and 20% residual stenosis after CAS. Results Oval or outward expansion is directly related to residual stenosis. The oval expansion was associated with maximum plaque thickness, and outward expansion was associated with the presence of a calcification barrier. Variables related to > 20% residual stenosis were the maximum plaque thickness, calcification barrier, and pre-CAS stenotic degree. Conclusions CBCT for carotid stenosis may provide valuable information about plaque features, especially calcification features that may interfere with the angioplasty effect, as well as the characteristics and quality of stent expansion. Residual stenosis > 20% was associated with calcification barrier, maximum plaque thickness, and pre-CAS stenotic degree.
The effect of diabetes mellitus on the outcome of surgery for cubital tunnel syndrome
Authors: Stirling Paul H. C. , Harrison Simon J. , McEachan Jane E. 
Published: December 2022

The aims of this study were to investigate the effect of diabetes mellitus (DM) on patient-reported outcome measures (PROMs) and satisfaction after surgery for cubital tunnel syndrome (CuTS). Pre- and 1-year postoperative QuickDASH, normal hand, and satisfaction scores were prospectively collected from 107 patients over a 6-year period. Patients without DM reported a significant QuickDASH improvement after surgery (preoperative 34.1 versus postoperative 20.5; p < 0.001), but patients with DM did not (preoperative 46.5 versus postoperative 43.2; p = 0.554). Postoperative QuickDASH (43.2 versus 20.5) and normal hand (65 versus 80) scores were significantly worse in patients with DM. Satisfaction rates were excellent in both groups (88% versus 82%; p = 0.480). Our study showed that surgery for CuTS did not lead to an improvement in QuickDASH score in patients with DM and consequently patients with DM reported worse postoperative PROMs compared with those without. However, lack of improvement in PROMs does not affect patient satisfaction. Level of evidence: IV
Psychometric Properties of the Suicidal Ideation Scale in the Indonesian Language
Authors: Fitriana Efi , Purba Fredrick Dermawan , Salsabila Safira Putri , Danasasmita Febrianti Santiardi , Afriandi Irvan , Tarigan Rodman , Ichsan Abdullah , Pandia Veranita 
Published: December 2022

Introduction: Suicide is one of the leading cause of mortality among adolescents and young adults, especially in low to middle-income countries. Research found that screening for suicidal ideation in non-clinical populations such as schools or communities is an important step toward preventing suicide. Despite so, not all screening tools have the capabilities to accurately detect suicidal ideation among adolescents and young adults in non-clinical populations. The Suicidal Ideation Scale (SIS) is one of the most used questionnaires to measure suicidal thoughts in non-clinical populations. This study aims to investigate the psychometric properties of SIS among adolescents and young adults in Indonesia, especially in non-clinical populations. Methods: After a series of language and cultural adaptations, 1254 senior high school and university students completed the Indonesian version of SIS using 3 standard questionnaires, namely Patient Health Questionnaire-9/PHQ-9, Beck Depression Inventory-II/BDI-II, and Children’s Depression Inventory/CDI. The SIS content validity, internal consistency, test-retest reliability and concurrent, as well as internal structure validity, were investigated using content validity index (CVI), Cronbach’s Alpha, Pearson product-moment correlation, and confirmatory factor analysis (CFA), respectively. Results: The result showed that SIS has good to excellent internal consistency and test-retest reliability. Based on the validity indicators, it has satisfactory content and convergent validity, and further support the one-factor and 2-factor model for factorial validity. Both one-factor and 2 factor model are suitable to use in non-clinical settings. Conclusions: SIS is a valid and reliable tool for suicide ideation screening in adolescents and young adults in non-clinical populations. This validated questionnaire can be used in the early detection of suicidal ideation among adolescents and young adults in non-clinical populations, thus contributing to developing strategies and policies to prevent suicide among Indonesian adolescents and young adults at group and institutional levels.
The DynAIRx Project Protocol: Artificial Intelligence for dynamic prescribing optimisation and care integration in multimorbidity
Authors: Walker Lauren E , Abuzour Aseel S , Bollegala Danushka , Clegg Andrew , Gabbay Mark , Griffiths Alan , Kullu Cecil , Leeming Gary , Mair Frances S , Maskell Simon , Relton Samuel , Ruddle Roy A , Shantsila Eduard , Sperrin Matthew , Van Staa Tjeerd , Woodall Alan , Buchan Iain 
Published: December 2022

Background Structured Medication Reviews (SMRs) are intended to help deliver the NHS Long Term Plan for medicines optimisation in people living with multiple long-term conditions and polypharmacy. It is challenging to gather the information needed for these reviews due to poor integration of health records across providers and there is little guidance on how to identify those patients most urgently requiring review. Objective To extract information from scattered clinical records on how health and medications change over time, apply interpretable artificial intelligence (AI) approaches to predict risks of poor outcomes and overlay this information on care records to inform SMRs. We will pilot this approach in primary care prescribing audit and feedback systems, and co-design future medicines optimisation decision support systems. Design DynAIRx will target potentially problematic polypharmacy in three key multimorbidity groups, namely, people with (a) mental and physical health problems, (b) four or more long-term conditions taking ten or more drugs and (c) older age and frailty. Structured clinical data will be drawn from integrated care records (general practice, hospital, and social care) covering an ∼11m population supplemented with Natural Language Processing (NLP) of unstructured clinical text. AI systems will be trained to identify patterns of conditions, medications, tests, and clinical contacts preceding adverse events in order to identify individuals who might benefit most from an SMR. Discussion By implementing and evaluating an AI-augmented visualisation of care records in an existing prescribing audit and feedback system we will create a learning system for medicines optimisation, co-designed throughout with end-users and patients.
Three-dimensional Analysis of Phenotypic Variation in Mercedes Benz Craniosynostosis
Authors: Harrison Lucas M. , Mathew Denzil P. , Hallac Rami R. , Derderian Christopher A. 
Published: December 2022

Background: Mercedes Benz craniosynostosis is a rare tri-sutural closure pattern of the bilateral lambdoid and sagittal sutures. Variation due to the predominant deformational driving force leads to short and long phenotypes. This study aims to evaluate the volumetric and craniometrics differences between phenotypes and compare them to controls. Methods: Three-dimensional pre-operative CT scans of 15 patients with Mercedes Benz craniosynostosis were retrospectively reviewed along with age and gender-matched controls. The intracranial volume of the anterior, middle, and posterior fossa was calculated. Craniometric measurements included cranial index, frontal bossing angle, occipital bossing angle, and occipital bone angle. Results: The short phenotype was present in 60% of patients, and the long phenotype in 40%. The short phenotype volume was significantly greater in the anterior and middle fossa ( P = .003; P = .002) and significantly less in the posterior fossa ( P < .001). The volumes were not significantly different in the long phenotype. The cranial index was significantly greater in the short phenotype when compared to both the long phenotype and controls ( P < .001; P = .006). Occipital bossing angle was significantly greater in the short phenotype than in controls( P = .029). The short phenotype had a significantly decreased occipital bone angle compared to the long phenotype and controls ( P < .001; P = .001). Conclusion: The short phenotype has increased anterior and middle fossa and decreased posterior fossa volume. Long phenotype had no significant differences in volume distribution. The short phenotype has increased cranial index, increased occipital bossing angle, and decreased occipital bone angle. Craniometric measures were not significantly different in the long phenotype.
Human iPSC-derived neural stem cells with ALDH5A1 mutation as a model of succinic semialdehyde dehydrogenase deficiency
Authors: Chen Xiaodan , Peng Minzhi , Cai Yanna , Zhou Chengcheng , Liu Li 
Published: December 2022

Abstract
Background
Succinic semialdehyde dehydrogenase deficiency (SSADH-D) is an autosomal recessive gamma-aminobutyric acid (GABA) metabolism disorder that can arise due to ALDH5A1 mutations, resulting in severe, progressive, untreatable neurodegeneration. SSADH-D is primarily studied using simplified models, such as HEK293 cells overexpressing genes of interest, but such overexpression can result in protein aggregation or pathway saturation that may not be representative of actual underlying disease phenotypes.

Methods
We used a CRISPR/Cas9 approach to generate human iPSC cell lines bearing ALDH5A1 mutations. Through screening, two different mutant cell lines, NM_001080.3: c.727_735del (p.L243_S245del) and NM_001080.3: c.730_738del (p.A244_Q246del), were obtained. We induced iPSCs to neural stem cells and analyzed the characteristics of ALDH5A1 mutations in stem cells.

Results
The human iPSC and NSC cell lines presented typical stem cell–like morphology. We found changes in ALDH5A1 expression and GABA accumulation in the different cell lines. In addition, by analyzing the cDNA between the wild-type and the mutant cell lines, we found that the mutant cell lines had a splicing variant.

Conclusions
iPSCs represent a promising in vitro model for SSADH-D that can be used to study early central nervous system developmental alterations and pathogenic mechanisms.