bluuebunny/crossref_metadata_2025_split huggingface dataset:
TDTHub, a web server tool for the analysis of transcription factor binding sites in plants
Authors: Grau Joaquín , Franco‐Zorrilla José M. 
Published: June 2022

SUMMARYTranscriptional regulation underlies most developmental programs and physiological responses to environmental changes in plants. Transcription factors (TFs) play a key role in the regulation of gene expression by binding specifically to short DNA sequences in the regulatory regions of genes: the TF binding sites (TFBSs). In recent years, several bioinformatic tools have been developed to detect TFBSs in candidate genes, either by de novo prediction or by directly mapping experimentally known TFBSs. However, most of these tools contain information for only a few species or require multi‐step procedures, and are not always intuitive for non‐experienced researchers. Here we present TFBS‐Discovery Tool Hub (TDTHub), a web server for quick and intuitive studies of transcriptional regulation in plants. TDTHub uses pre‐computed TFBSs in 40 plant species and allows the choice of two mapping algorithms, providing a higher versatility. Besides the main TFBS enrichment tool, TDTHub includes additional tools to assist in the analysis and visualization of data. In order to demonstrate the effectiveness of TDTHub, we analyzed the transcriptional regulation of the anthocyanin biosynthesis pathway. We also analyzed the transcriptional cascades in response to jasmonate and wounding in Arabidopsis and tomato (Solanum lycopersicum), respectively. In these studies, TDTHub helped to verify the most relevant TF nodes and to propose new ones with a prominent role in these pathways. TDTHub is available at http://acrab.cnb.csic.es/TDTHub/, and it will be periodically upgraded and expanded for new species and gene annotations.
How nursing stakeholders in the Republic of Ireland define evidence‐based practice and why it matters
Authors: Cleary‐Holdforth Joanne , Fineout‐Overholt Ellen , O'Mathúna Dónal 
Published: June 2022

AbstractBackgroundEvidence‐based practice (EBP) has garnered increasing exposure in professional healthcare discourse over three decades. While the term is used frequently, its interpretation varies widely. An accurate, shared understanding of what EBP means is essential to the achievement of EBP implementation in clinical practice. As part of a national study in the Republic of Ireland, nurses, midwives, educators, and students shared their personal understanding of what EBP was to them.AimTo establish nurses', midwives', educators', and students' knowledge and understanding of the concept of EBP in the Republic of Ireland.MethodsIn a national study exploring EBP beliefs, implementation, and organizational readiness for EBP among nurses, midwives, educators, and students, an open‐ended question invited participants to explain what EBP is, in their own words. Content analysis was used to interpret participants' responses.ResultsFive themes emerged from the data from the single open‐ended question: (1) varying definitions of EBP, (2) best practice, (3) nurses' and midwives' role in EBP, (4) knowledge, and (5) barriers and facilitators of EBP. The dominant finding centered on the substantial conflation of EBP with research utilization and other concepts such as quality improvement.Linking Evidence to ActionPoor knowledge and understanding of EBP is a fundamental challenge to EBP implementation. Conflation of EBP with research utilization and other healthcare concepts is not uncommon among nurses and midwives globally and has persisted for some time. This has the potential to hinder the advancement of EBP in nursing and midwifery and, therefore, measures to enhance EBP knowledge and promote EBP implementation are key. Professional regulating bodies, educators, and clinical and educational organizations all have a role to play. The findings from this aspect of this national study offer a realistic, context‐specific starting point for tailored educational interventions for clinicians, educators, and students and identify professional and organizational strategies that promote EBP as the expectation and “the way things are done here.”
Improved blood pressure and flow‐mediated dilatation via increased plasma adropin and nitrate/nitrite induced by high‐intensity interval training in patients with type 2 diabetes
Authors: Davoodi Mohsen , Hesamabadi Behnam Keshtkar , Ariabood Erfaneh , Izadi Mohammad Reza , Ghardashi‐Afousi Alireza , Bigi Mohammad Ali Babaee , Asvadi‐Fard Maryam , Gaeini Abbas Ali 
Published: June 2022

New Findings
What is the central question of this study?
Exercise training increases adropin and nitrite/nitrate (NOx) plasma levels in middle‐aged and older healthy people. We hypothesized that high‐intensity interval training may improve blood pressure and flow‐mediated dilatation through the effects of adropin and NOx in patients of this age with type 2 diabetes.
What is the main finding and its importance?
High‐intensity interval training may be more effective than moderate‐intensity continuous training in improving endothelial function, blood pressure and flow‐mediated dilatation through its effects on adropin and NOx in patients with type 2 diabetes.
AbstractAdropin is a newly identified bioactive protein that is important in energy hemostasis and vascular endothelial function. Lower levels of adropin in patients with type 2 diabetes are related to coronary atherosclerosis, characterized by impaired flow‐mediated dilatation (FMD). The purpose of the present study was to investigate FMD and plasma levels of adropin and nitrite/nitrate (NOx) in patients with type 2 diabetes at baseline and follow‐up after 12 weeks of high‐intensity interval training (HIIT) or moderate‐intensity continuous training (MICT). Sixty‐six persons with type 2 diabetes were divided into HIIT, MICT, and control groups. The HIIT group intervention was 12 intervals (1.5 min) at 85–90% maximal heart rate (HRmax) separated by 2 min at 55–60% HRmax in three sessions per week for 12 weeks. MICT training consisted of 42 min of cycling at 70% HRmax. Before and after the intervention, FMD was recorded with high‐resolution Doppler ultrasound. Plasma levels of adropin and NOx were measured by enzyme‐linked immunosorbent assay. After training FMD was significantly higher in the MICT and HIIT groups compared to the control group (P < 0.05). Plasma levels of adropin and NOx were higher in both exercise groups, but the increase was greater in the HIIT group (P < 0.01). Peak oxygen consumption was increased after exercise training in both groups compared to the control group (P < 0.01). Percentage FMD showed a positive correlation with plasma levels of adropin and NOx (both P < 0.01), and a negative correlation with diastolic blood pressure (r = −0.530, P = 0.035) and systolic blood pressure (r = −0.606, P = 0.013) in the HIIT group. The results indicate that HIIT improved FMD whilst increasing adropin, NOx and peak oxygen consumption. Increased plasma levels of adropin may contribute, in part, to blood pressure reduction by increasing nitric oxide production.
Electroencephalographic response to transient adaptation of vestibular perception
Authors: Cooke Josephine I. , Guven Onur , Castro Abarca Patricia , Ibitoye Richard T. , Pettorossi Vito E. , Bronstein Adolfo M. 
Published: June 2022

AbstractWhen given a series of sinusoidal oscillations in which the two hemicycles have equal amplitude but asymmetric velocity, healthy subjects lose perception of the slower hemicycle (SHC), reporting a drift towards the faster hemicycle (FHC). This response is not reflected in the vestibular–ocular reflex, suggesting that the adaptation is of higher order. This study aimed to define EEG correlates of this adaptive response. Twenty‐five subjects underwent a series of symmetric or asymmetric oscillations and reported their perceived head orientation at the end using landmarks in the testing room; this was converted into total position error (TPE). Thirty‐two channel EEG was recorded before, during and after adaptation. Spectral power and coherence were calculated for the alpha, beta, delta and theta frequency bands. Linear mixed models were used to determine a region‐by‐condition effect of the adaptation. TPE was significantly greater in the asymmetric condition and reported error was always in the direction of the FHC. Regardless of condition, alpha desynchronised in response to stimulation, then rebounded back toward baseline values. This pattern was accelerated and attenuated in the prefrontal and occipital regions, respectively, in the asymmetric condition. Functional connectivity networks were identified in the beta and delta frequency bands; these networks, primarily comprising frontoparietal connections, were more coherent during asymmetric stimulation. These findings suggest that the temporary vestibulo‐perceptual ‘neglect’ induced by asymmetric vestibular stimulation may be mediated by alpha rhythms and frontoparietal attentional networks. The results presented further our understanding of brain rhythms and cortical networks involved in vestibular perception and adaptation.
imageKey points
Whole‐body asymmetric sinusoidal oscillations, which consist of hemicycles with equal amplitude but differing velocities, can induce transient ‘neglect’ of the slower hemicycle in the vestibular perception of healthy subjects.
In this study, we aimed to elucidate EEG correlates of this ‘neglect’, thereby identifying a cortical role in vestibular perception and adaptation.
We identified a desynchronisation–resynchronisation response in the alpha frequency band (8–14 Hz) that was accelerated in the prefrontal region and attenuated in the occipital region when exposed to asymmetric, as compared to symmetric, rotations.
We additionally identified functional connectivity networks in the beta (14–30 Hz) and delta (1–4 Hz) frequency bands consisting primarily of frontoparietal connections.
These results suggest a prominent role of alpha rhythms and frontoparietal attentional networks in vestibular perception and adaptation.
Evaluating a system-wide, safety investigation in healthcare course in Norway: a qualitative study
Authors: Haraldseid-Driftland Cecilie , Macrae Carl , Guise Veslemøy , Schibevaag Lene , Alsvik Janne Gro , Rosenberg Adriana , Wiig Siri 
Published: June 2022

Objective and settingNational, system-wide safety investigation represents a new approach to safety improvement in healthcare. In 2019, a new master’s level course in Safety Investigation in Healthcare was established to support the training and development of a new team of investigators from an independent investigatory body. The course was established at one Norwegian university and a total of 19 students were enrolled and completed the course. The aim of this study was to qualitatively evaluate the course, and the objectives were to explore the students’ needs and expectations prior to the course conduct, and their experiences and suggestions for improvements after course completion.DesignThe study design was a qualitative explorative study with individual and focus group interviews. Data collection included five individual interviews prior to course participation and two focus group interviews, after course participation, with a total sample size of 13 participants. Data were analysed according to thematic analysis.ResultsThe results showed a need for a common conceptual foundation for the multidisciplinary team of safety investigators who were all employed in the same investigatory body. Course participation contributed to create reflexive spaces for the participants and generated new knowledge about the need for a broad range of investigatory tools and approaches. This contrasted with the initial aspiration among the participants to have a recipe for how to conduct safety investigations.ConclusionsCourse participation contributed to a common language among a highly multidisciplinary group of safety investigators and supported building a culture of collaborative learning. The need for additional activities to further develop a safety investigation curriculum in healthcare was identified. It is recommended that such a curriculum be co-created with independent investigators, safety scientists, patients and users, and healthcare professionals to ensure a strong methods repertoire and a sound theoretical backdrop for investigatory practice.
International perspective on healthcare provider gender bias in musculoskeletal pain management: a scoping review protocol
Authors: Wilford Katherine Fisher , Mena-Iturriaga Maria Jesus , Vugrin Margaret , Wainer Macarena , Sizer Phillip S , Seeber Gesine Hendrijke 
Published: June 2022

IntroductionChronic pain affects millions of individuals worldwide. Healthcare provider gender bias in the management of these individuals has societal and individual ramifications. Yet, a thorough and comprehensive literature summary on this topic is lacking. Therefore, this study aims to systematically: (1) identify and map the available scientific and grey literature as it relates to healthcare provider gender bias in the assessment, diagnosis and management of (chronic) musculoskeletal pain and (2) identify current gaps that necessitate further research.Methods and analysisThis scoping review will be conducted in accordance with recent guidelines, and the results will be reported via the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews. The following databases will be searched: PubMed (National Library of Medicine), Embase (Elsevier), Scopus (Elsevier), CINAHL Complete (Ovid), Academic Search Complete (Ebscohost), Pre-Prints Database (National Library of Medicine) and Rehabilitation Reference Center from inception to August 2022. Additionally, relevant grey literature will be identified. All screening will be done by two independent reviewers during two stages: first title/abstract screening followed by full-text screening. Data will be extracted from the bibliometric, study characteristics, and pain science families of variables. Results will be descriptively mapped, and the frequency of concepts, population, characteristics and other details will be narratively reported. Additionally, results will be presented in tabular and graphical form.Ethics and disseminationAs this study will neither involve human subject participation nor utilisation of protected data, ethical approval is not required. This study’s methodological approach follows current recommendations. Study findings will be disseminated through conference presentations and international peer-review journal publication. In addition, infographics available in English, Spanish and German will be disseminated.Registration detailsThis project will be registered in Open Science Framework prior to data collection.
Aortic stenosis post-COVID-19: a mathematical model on waiting lists and mortality
Authors: Stickels Christian Philip , Nadarajah Ramesh , Gale Chris P , Jiang Houyuan , Sharkey Kieran J , Gibbison Ben , Holliman Nick , Lombardo Sara , Schewe Lars , Sommacal Matteo , Sun Louise , Weir-McCall Jonathan , Cheema Katherine , Rudd James H F , Mamas Mamas , Erhun Feryal 
Published: June 2022

ObjectivesTo provide estimates for how different treatment pathways for the management of severe aortic stenosis (AS) may affect National Health Service (NHS) England waiting list duration and associated mortality.DesignWe constructed a mathematical model of the excess waiting list and found the closed-form analytic solution to that model. From published data, we calculated estimates for how the strategies listed under Interventions may affect the time to clear the backlog of patients waiting for treatment and the associated waiting list mortality.SettingThe NHS in England.ParticipantsEstimated patients with AS in England.Interventions(1) Increasing the capacity for the treatment of severe AS, (2) converting proportions of cases from surgery to transcatheter aortic valve implantation and (3) a combination of these two.ResultsIn a capacitated system, clearing the backlog by returning to pre-COVID-19 capacity is not possible. A conversion rate of 50% would clear the backlog within 666 (533–848) days with 1419 (597–2189) deaths while waiting during this time. A 20% capacity increase would require 535 (434–666) days, with an associated mortality of 1172 (466–1859). A combination of converting 40% cases and increasing capacity by 20% would clear the backlog within a year (343 (281–410) days) with 784 (292–1324) deaths while awaiting treatment.ConclusionA strategy change to the management of severe AS is required to reduce the NHS backlog and waiting list deaths during the post-COVID-19 ‘recovery’ period. However, plausible adaptations will still incur a substantial wait to treatment and many hundreds dying while waiting.
Effect of electrical stimulation with a cochlear implant on tinnitus impact: protocol of an individual patient data meta-analysis
Authors: Assouly Kelly , Smit Adriana L , Stegeman Inge 
Published: June 2022

IntroductionTinnitus is the perception of sound without an external stimulus, often experienced as a ringing, buzzing sound. While several studies have shown a reduction in tinnitus distress following cochlear implantation, others showed an increase or no change after implantation. At this stage, clinicians have little certainty when counselling their patients prior to implantation regarding tinnitus post-implantation. To help clinicians to counsel cochlear implant (CI) candidates on the risk of developing or improving tinnitus after implantation, we aim to assess the effect of electrical stimulation with a CI on tinnitus impact for individual adult patients with tinnitus. We will also apply prediction models to individual patient data (IPD) of clinical trials to find predictive factors of the effect of electrical stimulation on tinnitus impact.Method and analysisThe IPD meta-analysis is a follow-up project of the systematic review on cochlear implantation in patients with tinnitus as a primary complaint. First, the systematic searches will be updated to date. Methodological quality of eligible studies will be assessed using the Risk of Bias In Non-randomised Studies of Intervention tool (ROBINS-I). Based on a data-sharing agreement, authors of the eligible studies will be invited to share their deidentified and complete IPD. The primary outcome is the effect of electrical stimulation with a CI on tinnitus impact 1 month or more post-implantation. IPD meta-analysis will be used to assess the primary outcome, while differentiating the tinnitus impact questionnaires. Second, linear regression analyses will be used to model the effect of electrical stimulation on tinnitus impact based on relevant predictors.Ethics and disseminationThe Medical Research Involving Human Subject Act does not apply, and ethical approval is not required. The study results will be made accessible to the public in a peer-review open access journal.PROSPERO registration numberCRD42022319367, review ongoing.
Triple Higgs couplings in the 2HDM: the complete picture
Authors: Arco F. , Heinemeyer S. , Herrero M. J. 
Published: June 2022

AbstractThe measurement of the triple Higgs coupling is one of the main tasks of the (HL-)LHC and future lepton colliders. Similarly, triple Higgs couplings involving BSM Higgs bosons are of high interest. Within the framework of Two Higgs Doublet Models (2HDM) we investigate the allowed ranges for all triple Higgs couplings involving at least one light, SM-like Higgs boson. We present newly the allowed ranges for 2HDM type III and IV and update the results within the type I and II. We take into account theoretical constraints from unitarity and stability, experimental constraints from direct BSM Higgs-boson searches, measurements of the rates of the SM-like Higgs-boson at the LHC, as well as flavor observables and electroweak precision data. For the SM-type triple Higgs coupling w.r.t. its SM value,$$\lambda _{hhh}/\lambda _{\mathrm{SM}}$$λhhh/λSM, we find allowed intervals of$$\sim [{-0.5}, {1.3}]$$∼[-0.5,1.3]in type I and$$\sim [{0.5}, {1.0}]$$∼[0.5,1.0]in the other Yukawa types. These allowed ranges have important implications for the experimental determination of this coupling at future collider experiments. We find the coupling$$\lambda _{hhH}$$λhhHbetween$$\sim -1.5$$∼-1.5and$$\sim +1.5$$∼+1.5in the four Yukawa types. For the triple Higgs couplings involving two heavy neutral Higgs bosons,$$\lambda _{hHH}$$λhHHand$$\lambda _{hAA}$$λhAAwe find values between$$\sim -0.5$$∼-0.5and$$\sim 16$$∼16, and between$$\sim -1$$∼-1and$$\sim 32$$∼32for$$\lambda _{hH^+H^-}$$λhH+H-. These potentially large values could lead to strongly enhanced production of two Higgs-bosons at the HL-LHC or high-energy lepton colliders.
HOW DOES SERVANT LEADERSHIP INCREASE THE COMPETITIVENESS OF STARTUP TEAMS? THE MEDIATING ROLE OF EMPLOYEES’ SELF-EFFICACY
Authors: ALIKHANI ZAHRA , SHAHRIARI MOHSEN 
Published: June 2022

Purpose—The purpose of this study is to examine the effect of servant leadership on competitiveness of startups. Also, the role of self-efficacy as a mediator between servant leadership and competitiveness has been explored.Design/methodology/approach—Servant leadership, competitiveness and self-efficacy were evaluated in an empirical study based on a sample of 220 employees of Iranian start-up companies.The data analysis was performed through a two-stage partial least squares structural equation modeling technique. In the first stage, the measurement models were examined in terms of construct validity and reliability, while in the second stage, the structural model and research hypotheses were tested.Findings—The results demonstrated that servant leadership positively affects competitiveness. Also, as expected, self-efficacy act as a mediating variable between servant leadership and competitiveness.Practical implications—Start-ups nowadays constitute a large portion of countries’ financial turnover and economy. Considering the sharp increase in competitiveness and instability in the market, start-ups with transformational leadership are more likely to succeed. However, other styles, such as servant leadership, could play an essential role in guiding these startup companies on the way of competitiveness by strengthening employees’ empowerment and self-efficacy.Originality/value—It is believed that the important contribution of this study is demonstrating the effects of servant leadership on competitiveness of startups. Also, the mediating role of self-efficacy in this relationship has been strongly confirmed.
O percurso mítico do meio-dia (análise simbólica de um poema de Aimé Césaire)
Authors: Porto Maria Bernardette Velloso 
Published: June 2022

O conjunto poético Les armes miraculeuses, publicado em 1946 pela Editora Gallimard, não mereceu ainda estudos críticos à sua altura. Escolhemos, para objeto de análise de nossa dissertação de mestrado, o poema "Le grand midi". Texto denso e vigoroso, revela o enontro entre o surrealismo e a concepção da negritude, entre mitos greco-latinos e mitos africanos. Sua interpretação se vê dificultada pela inexistência de uma boa bibliografia crítica sobre seu autor. De modo geral, as leituras feitas da obra poética de Cesáire, em número reduzido, preocupam-se ora em realçar o engajamento do poeta, ora em parafrasear o próprio texto, como é o caso dos estudos de Kestellot, Kotchy e Juin.