bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analysis of the climate change impact on water availability and the links between water pollution and economy for sustainable water resource management in Kaski District, Nepal
Authors: Chapagain Saroj Kumar , Aryal Anil , Mohan Geetha , Shrestha Sadhana , Mishra Binaya Kumar , Fukushi Kensuke 
Published: July 2022

Abstract
The newly enacted national water policy is envisioned as ensuring water sustainability in Nepal. Despite theoretical pertinence, questions remain about the effective implementation due to limited studies on key aspects of sustainability, such as water supply and demand, pollution, and impacts of climate change and socio-economic growth. This study analyses the current and future availability of water under climate change scenarios and determines water resources carrying capacity (WRCC) as the maximum socio-economic growth that can be supported in a case study on the Kaski District, Nepal. Annual average water availability was estimated to be 11,030.7 million cubic meters (MCM) for the baseline period (1992–2010), and 7,677.4 and 7,674.2 MCM for the future period (2022–2050) under the representative concentration pathway (RCP) 4.5 and 8.5 emission scenarios, respectively. For the baseline period, WRCC far exceeds the current population; therefore, water resources will not be a limiting factor for local socio-economic development. Nevertheless, sustainable water infrastructure development policies are necessary to ensure a reliable water supply able to cope with increasing seasonal variability and declining future water availability. A total of 30,049 tons of biological oxygen demand (BOD) loads were estimated based on the economic activities of the Kaski District in 2011, with the direct and indirect sectoral roles of water pollution determined for the first time. Rather than a single pollution control strategy based on pollution loads, multiple sector-specific strategies are necessary to effectively implement water pollution control policies.
Potentially pathogenic Escherichia coli from household water in peri-urban Ibadan, Nigeria
Authors: Rabiu Akeem Ganiyu , Falodun Olutayo Israel , Fagade Obasola Ezekiel , Dada Rotimi Ayodeji , Okeke Iruka N. 
Published: July 2022

Abstract
Feco-orally transmitted infectious diseases are common in Nigeria where the potable water access is poor. In the south-western Nigerian Ibadan metropolis, supply of municipal water is meagre as residents depend on household wells and boreholes. The likelihood of fecal contamination of household water sources in Ibadan was examined longitudinally to quantify and understand its impact. Well and borehole water samples aseptically collected from 96 households in Ibadan were assessed for total heterotrophic counts (THCs), total coliform counts (TCCs) and total Escherichia coli counts (TECs) using a pour plate technique. E. coli were identified by uidA and whole-genome sequencing using Illumina technology, whereas virulence factors were predicted using VirulenceFinder. There was season-independent abundance of THC and TCC in the well and borehole with a significant recovery of E. coli in the wells during the wet season compared to the dry season (P = 0.0001). Virulence genes associated with pathogenic E. coli were identified in 13 (52%) strains with one E. coli each classified as extra-intestinal E. coli, avian pathogenic E. coli and enteroaggregative E. coli. High heterotrophic and coliform counts, with rainfall-driven E. coli contamination revealed that the water sources evaluated in this study are unfit for consumption.
Usability and Effectiveness of an Individualized, Tablet-Based, Multidomain Exercise Program for People With Dementia Delivered by Nursing Assistants: Protocol for an Evaluation of the InCoPE-App
Authors: Barisch-Fritz Bettina , Bezold Jelena , Scharpf Andrea , Trautwein Sandra , Krell-Roesch Janina , Woll Alexander 
Published: July 2022

Background
The COVID-19 pandemic has had drastic consequences on everyday life in nursing homes. Limited personnel resources and modified hygiene and safety measures (eg, no external exercise instructors, no group settings) have often led to interrupted physical exercise treatments. As a consequence, people with dementia benefiting from individualized exercise programs are affected by the pandemic’s impact.

Objective
Our goal is to develop an easily applicable mobile application (Individualized Cognitive and Physical Exercise [InCoPE] app) allowing nursing assistants to test cognitive function and physical performance and subsequently train people with dementia through a multidomain, individualized exercise program.

Methods
We will evaluate the usability and effectiveness of the InCoPE-App by applying a mixed method design. Nursing assistants will use the InCoPE-App for 18 weeks to assess the cognitive function and physical performance of 44 people with dementia every 3 weeks and apply the individualized exercise program. We will record overall usability using questionnaires (eg, Post-Study System Usability and ISONORM 9241/10), log events, and interviews. Perceived hedonic and pragmatic quality will be assessed using the AttrakDiff questionnaire. Effectiveness will be evaluated by considering changes in quality of life as well as cognitive function and physical performance between before and after the program.

Results
Enrollment into the study will be completed in the first half of 2022. We expect an improvement in the quality of life of people with dementia accompanied by improvements in cognitive function and physical performance. The usability of the InCoPE-App is expected to be rated well by nursing assistants.

Conclusions
To date, there is no scientifically evaluated app available that enables nursing assistants without expertise in sports science to deliver an individualized exercise program among people with dementia. A highly usable and effective InCoPE-App allows nursing assistants to test cognitive function and physical performance of people with dementia and, based thereon, select and deliver an appropriate individualized exercise program based on the cognitive and physical status of an individual, even in times of a pandemic.

Trial Registration
German Register of Clinical Trials DRKS00024069; https://www.drks.de/drks_web/navigate.do?navigationId=trial.HTML&TRIAL_ID=DRKS00024069

International Registered Report Identifier (IRRID)
DERR1-10.2196/36247
Examining Mental Workload Relating to Digital Health Technologies in Health Care: A Systematic Review focusing on Assessment Methods (Preprint)
Authors: Kremer Lisanne , Lipprandt Myriam , Röhrig Rainer , Breil Bernhard 
Published: July 2022

BACKGROUND

The workload in healthcare is steadily increasing – healthcare professionals (HCP) report stress and a very demanding environment. As a result, mental health issues are on the rise among HCP, the proneness to errors in tasks could increase. The digitization of patient care is intended to counteract processes of demographic change, that could be in relation to high stress levels. It remains unclear whether the Health Information System(s) (HIS) and digital health technologies (DHT) used, relieve the professionals or even represent a further burden. The mental construct that describes this burden of technologies is Mental Workload (MWL).
Work in the clinic can be viewed as working in safety-critical environments: Particularly in this sensitive setting, the measurement methods of MWL are relevant - mainly due to their strongly differing intrusiveness and sensitivity. The method of eye tracking could provide a useful way to measure MWL directly in the field.

OBJECTIVE

The systematic review addresses two different, but related objectives.
1.	In which manner do DHT contribute to the overall MWL of health care workers: which aspects or factors of DHT contribute to an increase of MWL?
2.	Which methods/ assessments are applied to measure MWL related to HIS/ Digital Technologies?
2.1.	Which role does Eye tracking/ Pupillometry play in context of measure?
2.2.	Which outcomes are being assessed via eye tracking?

METHODS

Following the PRISMA statement, we conducted a systematic review. Based on the research questions, we defined keywords that were combined to search terms. The review followed the following steps: literature search, article selection, data extraction, risk of bias assessment, data analysis and data synthesis.

RESULTS

The literature search process resulted in 25 included studies that have studied the resulting MWL of healthcare workers from using DHT in health care settings.
The main results can be grouped by two categories: assessment methods and factors of DHT contributing to MWL. A major part of the studies applied subjective methods for the assessment of MWL (Most applied method: NASA TLX). Eye tracking didn’t play a relevant role. The factors contributing to a higher MWL were clustered by organizational and system factors.

CONCLUSIONS

Our review of 25 papers shows a diverse assessment approach of MWL related to DHT of HCPs as well as two groups of relevant contributing factors to MWL
Although methodological biases were identified, we promote further research concentrating on adequate assessments for relevant settings. We also like to promote the evaluation of quality criteria.

CLINICALTRIAL

PROSPERO registration: CRD42021233271; https://www.crd.york.ac.uk/PROSPERO/display_record.php?ID=CRD42021233271&ID=CRD42021233271
Protocol: JMIR Res Protoc 2021;10(8): e29126; https://doi.org/10.2196/29126
Molecular Docking, Synthesis, Characterization, and Preliminary Cytotoxic evaluation of new 1, 3, 4-Thiadiazole Derivatives as Αlpha-Estrogen Receptor Modulator
Authors: M. Abdulkhaleq Zainab , Hassan Mohammed Mohammed , Suhail Wadi Jaafar 
Published: July 2022

Objective: This study concluded that these newly synthesized analogs may be represented as an exploitable source of new anticancer agents to fight breast cancer
Methods: Using The crystal structure of Human α Estrogen Receptor (α-ER) with a 4-HYDROXYTAMOXIFEN(standard) as a co-crystalized ligand was gained from the protein data-bank (PDB code 3ERT) as a result of docking the 1,3,4-thiadiazole derivatives compounds(M1-M3) give good docking scores compared to the standard. Compounds M1-M3 was synthesized by multistep procedures from the reaction of intermediate (benzyloxy)phenyl)-1,3,4-thiadiazole-2(3H)-thione derivatives (D1, D2) and the 4-bromo-1-(cyclic amine1-yl)butan-1-one derivatives intermediate (A1, A2). The chemical structures of the target compounds and their intermediates were confirmed by FT-IR, 1H NMR, and 13C NMR.
Results: The in-vitro cytotoxicity assay (MTT assay) demonstrated that compounds M1-M3 showed good inhibition ratios in Breast cancer cell line (MCF-7) comparable with drug control Tamoxifen
Conclusion: From the docking study, it was concluded that piperidine and methyl-piperazine moiety were very successful to bind tightly to alpha estrogen receptors by making numerous interaction modes.
Implementasi protokol kesehatan pada tatanan kehidupan era baru terhadap usaha perjalanan wisata di bali
Authors: Lumanauw Nelsye , Sumartana I Made 
Published: July 2022

Pandemi Covid-19 telah berdampak pada berbagai lini kehidupan, termasuk sektor pariwisata. Adanya pembatalan perjalanan oleh wisatawan, pembatasan pergerakan sosial dan larangan bepergian oleh berbagai wilayah dunia, mengakibatkan terpuruknya usaha perjalanan wisata. Berbagai upaya pemulihan pariwisata Bali dilakukan pemerintah, salah satunya kepemilikan sertifikat tatanan kehidupan era baru, sebagai jaminan keamanan dan kepercayaan bagi wisatawan. Kurangnya pemahaman terhadap tatanan kehidupan era baru, tampak pada masih sedikitnya perusahaan yang memiliki sertifikat tersebut. Kriteria tatanan kehidupan era baru dan implementasinya merupakan tujuan penelitian ini. Penelitian ini menggunakan metode analisis deskriptif kualitatif untuk menganalisis data implementasi protokol tatanan kehidupan era baru pada 25 usaha perjalanan wisata. Teori verifikasi dan sertifikasi digunakan untuk memperjelas ruang lingkup masalah yang diteliti. Kesimpulan penelitian ini adalah implementasi tatanan kehidupan era baru belum sepenuhnya dilaksanakan oleh usaha perjalanan wisata di Bali. Komitmen menerapkan protokol kesehatan menjadi kunci utama bagi wisatawan mancanegara mengunjungi destinasi wisata Bali memasuki era tatanan kehidupan baru.
Development and Evaluation of Self Micro Emulsifying Drug Delivery System (SMEDDS) for Nebivolol Hydrochloride
Authors: Ramya Sri Sura  , Subrahmanyam CVS  , Shyam Sunder Rachamalla  
Published: July 2022

The present investigation aimed to prepare a self micro emulsifying drug delivery system (SMEDDS) for the dissolution enhancement of nebivolol hydrochloride. The main objective of this work was to develop, characterize, and evaluate a solid SMEDDS prepared by using the adsorption technique of a liquid SMEDDS to improve the solubility and dissolution rate of nebivolol hydrochloride. The excipients were chosen based on the high solubility of nebivolol hydrochloride, and their concentrations were optimized by constructing ternary phase diagrams. Thirty-two combinations were prepared using oil (Labrafac Lipophile WL 1349), surfactant (Kolliphor RH 40), and co-surfactant (Gelucire 44/14). Self-emulsification time, dilution studies, and thermodynamic stability studies were satisfactory. The in vitro nebivolol release profile showed a faster rate of dissolution compared with the pure nebivolol hydrochloride suspension and marketed formulation. The droplet size was in the range of 132.8±22.1 to 955.7±15.5 nm and zeta potential in the range -7.2±0.53 mV to -46.4±0.32 mV for the selected formulations. Formulation N17 (Labrafac Lipophile WL 1349 -10%w/w, Kolliphor RH40-72%w/w, Gelucire 44/14- 18%w/w) was considered as optimized formulation and showed drug release of 97.26 ± 1.16% in 0.1 N HCl in 120 minutes, the particle size of 132.8±22.1 nm and zeta potential of -46.4±0.32 mV. Thus, the present studies ratify that the bioavailability was improved by nebivolol SMEDDS formulation. The optimized liquid SMEDDS was further used for the preparation of Solid SMEDDS (S-SMEDDS) formulations by using adsorption carriers. The optimized Solid SMEDDS formulation exhibited 95.38 ± 0.76% in vitro drug releases, which was significantly higher than that of the drug solution. The optimized formulation of nebivolol-loaded S-SMEDDS exhibited complete in vitro drug release in 120 min as a compared pure drug solution. The present result confirmed the potential use of SMEDDS to improve the dissolution and oral bioavailability of poorly water-soluble nebivolol.
Undiagnosed Diabetes in U.S. Adults: Prevalence and Trends
Authors: Fang Michael , Wang Dan , Coresh Josef , Selvin Elizabeth 
Published: July 2022

OBJECTIVE
Confirmatory testing is recommended for diabetes diagnosis in clinical practice. However, national estimates of undiagnosed diabetes are based on single elevated test measures, potentially resulting in overestimation. Our objective was to update trends in undiagnosed diabetes using definitions consistent with clinical practice.

RESEARCH DESIGN AND METHODS
We included 30,492 adults (aged ≥20 years) from the National Health and Nutrition Examination Survey (1988–2020). Among adults without diagnosed diabetes, confirmed undiagnosed diabetes was defined as having both elevated levels of fasting plasma glucose (FPG) (≥126 mg/dL) and elevated glycated hemoglobin (HbA1c; ≥6.5%), and persistent undiagnosed diabetes was defined as having elevated HbA1c or FPG levels, adjusted for the within-person variability in HbA1c and FPG tests.

RESULTS
From the periods 1988–1994 to 2017 to March 2020, there was an increase in the prevalence of diagnosed diabetes (from 4.6% to 11.7%), but no change in prevalence of persistent undiagnosed diabetes (from 2.23% to 2.53%) or confirmed undiagnosed diabetes (from 1.10% to 1.23%). Consequently, the proportion of all undiagnosed diabetes cases declined from 32.8% to 17.8% (persistent undiagnosed diabetes) and from 19.3% to 9.5% (confirmed undiagnosed diabetes). Undiagnosed diabetes was more prevalent in older and obese adults, racial/ethnic minorities, and those without health care access. Among persons with diabetes, Asian Americans and those without health care access had the highest proportion of undiagnosed cases, with rates ranging from 23% to 61%.

CONCLUSIONS
From 1988 to March 2020, the proportion of undiagnosed diabetes cases declined substantially, suggesting major improvements in diabetes screening and detection. Undiagnosed diabetes currently affects 1–2% of US adults; up to 90% of all cases are diagnosed.
Analysis of automated surface roughness parameter support systems based on dynamic monitoring
Authors: Gimadeev M. R. , Li A. A. 
Published: July 2022

Introduction. Domestic and foreign works on the milling of complex-profile surfaces with a ball-end tool were analyzed. Methods of surface quality control and ways to provide amplitude parameters of roughness, based on research data and field experiments, were considered. Theoretical provisions on the determination of cutting forces and the results of vibroacoustic diagnostics were presented.Materials and Methods. The methods of correlation analysis, comparison and generalization of the results were applied. The data were calculated at different tool angles, taking into account the instantaneous cutting forces, and were fixed in the range of values of the variable feed per tooth (fz) and the angle of inclination of the surface (γ). The vibroacoustic diagnostic data and theoretical data of the presented model at different tool inclination angles were verified by experiment. Consequently, such methods can be used to predict surface roughness parameters.Results. The relationship between cutting forces, tool inclination angle, and vibroacoustic diagnostics data was found. A model of the cutting force and tool displacements was formulated taking into account the inclination of the surface. The optimal range of the inclination angle of the tool to the surface to be machined, at which the minimum values of the amplitude parameters of roughness were achieved, was determined. The sound vibrations obtained empirically, presented in spectral and wave forms, were in good agreement with data from other sources. This allowed us to conclude about the feasibility of forecasting and monitoring roughness parameters in real time through acoustics.Discussion and Conclusions. It was established that the growth of forces in the direction ae(X) and fz(Y) was observed at γ > 40°. This was due to the distribution of the components of the cutting force along the cutting edge and depended on the inclination of the surface. The amplitude parameters decreased when the angle increased from 10 to 40 degrees. The found interrelations of force analysis, processing directions, and vibroacoustic diagnostics have validated the use of vibroacoustic diagnostics to predict surface roughness. Acoustic diagnostics, regardless of the layout of technological equipment, enables to quickly adjust the sound device and assess the impact of cutting modes on roughness parameters.
Pembelajaran Abad 21 dengan menggunakan Wikipedia sebagai Sumber Informasi untuk Meningkatkan Kemampuan Pemecahan Masalah
Authors: Nurul Hizqiyah Ida Yayu , Widodo Ari , Sriyati Siti 
Published: July 2022

Perkembangan teknologi yang pesat memberi kemudahan bagi kehidupan manusia di berbagai sektori. Sehingga manusia yang dibutuhkan dalam dunia kerja adalah yang mampu beradaptasi dengan perubahan teknologi, salah satunya dengan memiliki keterampilan pemecahan masalah. Program pendidikan telah mempersiapkan generasi yang memiliki keterampilan abad 21 dengan melatihkannya ke dalam pembelajaran. Teknologi membuat akses informasi lebih luas dan cepat. Sehingga penggunaanWikipedia bisa dijadikan alternative untuk memperoleh informasi sekaligus melatihkan keterampilan pemecahan masalah siswa. Dalam hal ini Wikipedia dijadikan sebagai sebuah media pembelajaran. Berkaitan dengan tersebut, tujuan penelitian ini adalah untuk menganalisis peningkatan keterampilan pemecahan masalah siswa siswa dengan menggunakan Ensiklopedi Online Wikipedia sebagai sumber informasi. Penelitian dilakukan dengan metode One group pretest-posttest karena penelitian mengukur keterampilan pemecahan masalah siswa sebelum dan sesudah belajar dengan menggunakan Ensiklopedi Online Wikipedia. Sampel pada penelitian ini diperoleh dengan metode purposive yang menerapkan kriteria-kriteria tertentu sehingga terpilih satu kelas yang terdiri dari 41 orang. Data keterampilan pemecahan masalah siswa dijaring dengan menggunakan instrumen tes pemecahan masalah. Hasil analisis data menunjukkan bahwa perolehan nilai N gain siswa berada pada kategori sedang, karena sebanyak 44% siswa memiliki nilai N-gain yang sedang. Kesimpulan dari penelitian ini adalah penggunaan Ensikopedi Online Wikipedia memiliki peluang dalam pembelajaran. Hal tersebut karena Ensikopedi Online Wikipedia menyediakan informasi secara cepat dan ringkas. Sehingga dapat dijadikan tempat pemberhentian pertama dalam mencari informasi.
Keragaman Jenis Tumbuhan Bawah di Taman Buru Gunung Masigit Kareumbi, Cicalengka
Authors: Gurnita Gurnita , Prasasti Anisa Rizki , Ibrahim Yusuf , Mulyadi Ahmad 
Published: July 2022

Sejak tahun 1950, Taman Buru Gunung Masigit Kareumbi (TBMK) sudah ditetapkan sebagai kawasan hutan konservasi dan saat ini TBMK dikelola oleh BKSDA yang bekerjasama dengan Perhimpunan Penempuh Rimba dan Pendaki Gunung Wanadri. Penelitian ini bertujuan untuk mengetahui jenis-jenis tumbuhan yang berada di bawah naungan tajuk hutan di TBMK. Metode yang digunakan dalam penelitian ini adalah metode deskriptif kualitatif dengan desain penelitian belt transect dan teknik pegambilan sampel dengan cara purposive sampling. Pada setiap 10 meter disepanjang garis transect dibuat plot-plot pengamatan yang berukuran 10 x 10 meter. Pembuatan belt transect dilakukan di hutan rasamala dan hutan pinus. Proses identifikasi dilakukan di Laboratorium Biologi FKIP Universitas Pasundan. Dari hasil identifikasi diketahui sebanyak 24 Ordo, 27 Family dan 44 jenis tumbuhan. Indeks keanekaragaman tumbuhan yang ada di bawah naungan tajuk hutan rasamala adalah 2.38 dan indeks keanekaragaman tumbuhan di bawah naungan tajuk hutan pinus yaitu 2.11. Hasil perhitungan Indexs Nilai Penting (INP) tertinggi di hutan rasamala yaitu 84.82 untuk tumbuhan Pilea angulata dan di hutan pinus yaitu 101.78 untuk tumbuhan Eupatorium riparium, serta index kesamaan komunitas antara dua lokasi yaitu 54 %.
Pembuatan dan Karakterisasi Self Emulsifying Drug Delivery Systems(SEDDS) Ibuprofen Secara Oral
Authors: Darusman Fitrianti , Amalia Frida Anggita , Priani Sani Ega 
Published: July 2022

Self emulsifying drug delivery systems (SEDDS) dikembangkan sebagai metode untuk meningkatkan kelarutan obat lipofilik seperti ibuprofen, serta untuk meningkatkan absorpsi dan laju disolusi obat. Oleh karena itu penelitian ini bertujuan untuk mengembangkan formulasi SEDDS ibuprofen yang memenuhi syarat secara farmasetik dan meningkatkan bioavailabilitas ibuprofen. Formula SEDDS diperoleh dari uji kelarutan ibuprofen dan optimasi formula pada berbagai konsentrasi minyak, surfaktan dan kosurfaktan. Asam oleat, cremophor RH 40 dan propilenglikol masing-masing terpilih sebagai minyak, surfaktan dan kosurfaktan dengan perbandingan fase minyak : (surfaktan + kosurfaktan) 1:9 dan pebandingan surfaktan : kosurfaktan (3:2). Formula SEDDS optimum dievaluasi meliputi pengukuran persen transmitan, pengujian dispersibilitas, pengujian robustness, pengujian stabilitas (sentrifugasi, heating cooling cycle, freeze thaw cycle), penentuan ukuran partikel dan uji laju disolusi. Formula SEDDS ibuprofen terbaik memenuhi persyaratan persen transmitan (99,7% ± 0,872), waktu dispersibilitas (41,48 detik ± 1,3), stabil pada pengujian robustness, tidak terjadi pemisahan fasa pada pengujian stabilitas, serta memiliki ukuran globul dalam kisaran mikrometer yaitu 114,7 ± 0,692 nm. Hasil uji laju disolusi in vitro pada menit ke-10 menunjukkan bahwa sediaan SEDDS ibuprofen lebih tinggi dibandingkan dengan serbuk ibuprofen murni, yaitu masing-masing sebesar 90,04 ± 1,764% dan 59,30 ± 1,638%.