bluuebunny/crossref_metadata_2025_split huggingface dataset:
Social and Psychiatric Aspects of the Emigration Problem in Ukraine
Authors: Petrivna Venger Olena ,   Department of Psychiatry, Narcology and Medical Psychology, I. Horbachevsky Ternopil State Medical University, Ternopil, Ukraine,   Olena Petrivna Venger, MD, PhD Ternopil Regional Clinical Psychoneurological Hospital 14, Trolleybusna Str.,46027, Ternopil, Ukraine Phone/Fax: +38 (0352) 43-57-71 Mobile: +38 (067) 756-55-56 E-mail: olenavenger@gmail.com, Ihorovych Mysula Yuriy ,   Department of Psychiatry, Narcology and Medical Psychology, I. Horbachevsky Ternopil State Medical University, Ternopil, Ukraine, Serhiivna Mysula Marianna ,   Department of Psychiatry, Narcology and Medical Psychology, I. Horbachevsky Ternopil State Medical University, Ternopil, Ukraine
Published: November 2022

The article presents data on a new scheme of complex treatment and rehabilitation of emigrants with psychogenic, endogenous and organic depressive disorders, as well as the results of comparative analysis of the effectiveness of this scheme, compared to the traditional one.
The use of the proposed treatment scheme also allowed to reduce the severity of anxiety, indicators of the severity of psychopathological symptoms, improve the quality of life among emigrants suffering from depressive disorders of different genesis.
The received results allow us to recommend the scheme we have developed for implementation in the complex treatment of emigrants suffering from depressive disorders of psychogenic, endogenous, and organic genesis.
Glucocorticoids and Trabecular Bone Score
Authors: Sandru Florica ,   Department of Dermatology, Elias Emergency University Hospital, Bucharest, Romania,   “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania, Carsote Mara ,   “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania,   Department of Endocrinology, C.I.Parhon National Institute of Endocrinology, Bucharest, Romania,   Mara Carsote C.I.Parhon National Institute of Endocrinology,Aviatorilor Ave 34-38,Bucharest, Romania.E-mail: carsote_m@hotmail.com, Cristian Dumitrascu Mihai ,   “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania,   Department of Gynecology, Emergency University Hospital, Bucharest, Romania, Elena Albu Simona ,   “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania,   Department of Gynecology, Emergency University Hospital, Bucharest, Romania, Valea Ana ,   Department of Endocrinology, Clinical County Hospital, Cluj-Napoca, Romania,   “Iuliu Hatieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania
Published: November 2022

TBS (Trabecular Bone Score) is the latest tool for clinicians to evaluate bone micro-architecture based on a pixel greyscale, which is provided by lumbar dual-energy X-ray absorptiometry (DXA). Its use enhances fracture prediction in addition to DXA-BMD (Bone Mineral Density). This is independent of fracture risk assessment (FRAX) and DXA results. We present a narrative review regarding the connection between TBS and Glucocorticoids (GC), either as a drug used for different conditions or as a tumor-produced endogenous excess.
TBS is a better discriminator for GC-induced vertebral fractures compared to DXA-BMD. This aspect is similarly available for patients with osteoporosis diagnosed by DXA. TBS is inversely correlated with the cumulative dose of GC (systemic or inhaled), with disease duration, and positively correlated with respiratory function in patients with asthma. Low TBS values are found in females with a T-score at the hip within the osteoporosis range, with diabetes mellitus, or who use GC. Lumbar TBS is a screening tool in menopausal women with type 2 diabetes mellitus. TBS is an independent parameter that provides information regarding skeleton deterioration in diabetic patients receiving GC therapy in a manner complementary to DXA-BMD. TBS might become an essential step regarding the adrenalectomy decision in patients with adrenal incidentaloma in whom autonomous cortisol secretion might damage bone micro-architecture. TBS currently represents a standard tool of fracture risk evaluation in patients receiving GC therapy or with endogenous Cushing’s syndrome, a tool easy to be applied by different practitioners since GCs are largely used
The Clinico-Epidemiological Profile of Patients with Gonorrhoea and Challenges in the Management of Neisseria gonorrhoeae Infection in an STI clinic, Ternopil, Ukraine (2013-2018)
Authors: Boiko Iryna ,   Department of Functional and Laboratory Diagnostics, I. Horbachevsky Ternopil National Medical University, Ternopil, Ukraine,   Iryna Boiko, M.D., PhD student Department of Functional and Laboratory Diagnostics I.Horbachevsky Ternopil National Medical University, 46000, Maidan Voli, 1, Ternopil, Ukraine. Phone: +380676821787 E-mail: iryna.boiko.ua@gmail.com, Akimova Viorika ,   Department of Clinical Laboratory Diagnostic, Danylo Halytsky Lviv National Medical University, Lviv, Ukraine, Mazur Lyudmyla ,   Department of Clinical Immunology, Allergology and General Patients’ Care, I. Horbachevsky Ternopil National Medical University, Ternopil, Ukraine;, Savchenko Iryna ,   First Department of Internal Medicine, I. Horbachevsky Ternopil National Medical University, Ternopil, Ukraine;, Kohut Ihor ,   Department of Infectious Diseases with Epidemiology, Skin and Sexually Transmitted Diseases, I. Horbachevsky Ternopil National Medical University, Ternopil, Ukraine., Krynytska Inna ,   Department of Functional and Laboratory Diagnostics, I. Horbachevsky Ternopil National Medical University, Ternopil, Ukraine
Published: November 2022

Gonorrhea is the second most common sexually transmitted infection spreading worldwide and a serious public health problem. How�ever, further data are required to improve the management of gonorrhea.
Our aim was to review the features of gonococcal infection and characterize the challenges of its management.
A retrospective descriptive study of the medical records of 136 adult patients with gonorrhea that visited Ternopil Regional Sexually Transmitted Infections Clinic (Ukraine) in 2013-2018 was performed.
The male-to-female ratio was 6.6:1. Homosexually-acquired gonorrhoea was 3.7%. Also, most patients acquired gonorrhea in Ukraine (98.4%). The mean infectious period lasted 2-16 days, including the incubation period of 1-9 days and the period from the onset of symptoms to the first visit of the clinic of 1-7 days. The probability of N. gonorrhoeae transmission within the frame of the epidemiologic sexual chain was 1:2.4. Concurrent T. vaginalis (39.7%) and C. trachomatis (2.2%) were detected. HIV and syphilis screening rates were 1.6% and 0.7%, respectively. The examining rate of sexual partners was 11%, testing extragenital specimens - 0.7%, screening coverage for HIV - 46.3%, compliance with follow-up visits - 41.9%. Part of patients (16.2%) received monotherapy with clarithromycin, doxycycline, benzylpenicillin, azithromycin, or ofloxacin.
The management of N. gonorrhoeae infections was compromised by a low rate of examining sexual partners, females and testing extragenital specimens, screening for HIV, compliance to follow-up visits, access to nucleic acid amplification tests, and receiving questionable or even obsolete antimicrobial treatment. Therefore, more accurate and comprehensive management of gonorrhea is urgently needed in Ukraine.
The Correlations of Clinical and Biochemical Indices of Vitamin D with Erectile Dysfunction
Authors: Dumbraveanu Ion ,   Department of Urology and Surgical Nephrology, Nicolae Testemiceanu State Medical and Pharmaceutical University, Chisinau, The Republic of Moldova, Banov Pavel ,   Department of Urology and Surgical Nephrology, Nicolae Testemiceanu State Medical and Pharmaceutical University, Chisinau, The Republic of Moldova,   Pavel Banov, Associate Professor, Department of Urology and Surgical Nephrology, Nicolae Testemiceanu State Medical and Pharmaceutical University, Chisinau, The Republic of Moldova, 29 Nicolae Testemitanu Street, Chisinau MD 2025, Chisinau 2004. Phone: +(373) 69080331. E-mail: pavel.banov@usmf.md, Arian Iurie ,   Department of Urology and Surgical Nephrology, Nicolae Testemiceanu State Medical and Pharmaceutical University, Chisinau, The Republic of Moldova, Ceban Emil ,   Department of Urology and Surgical Nephrology, Nicolae Testemiceanu State Medical and Pharmaceutical University, Chisinau, The Republic of Moldova
Published: November 2022

Erectile dysfunction is a multifactorial disease; it has been demonstrated that endothelial dysfunction plays an essential role in the pathogenesis of this disease, and Vitamin D deficiency is considered to favor endothelial lesions.
Our study, based on a group of 58 patients who have erectile dysfunction and a control group of 26 healthy subjects, tends to confirm that low levels of vitamin D could potentiate the severity of erectile dysfunction, promoting endothelial dysfunction.
Statistical analysis using the Pearson’s correlation criteria showed a robust and significant correlation between vitamin D levels and erectile dysfunction severity (ρ=0.752, p<0.000) according to the SHIM (Sexual Health Inventory For Men) questionnaire. Also, in patients with erectile dysfunction, there is a strong association between vitamin D and testosterone levels (ρ=0.728, p<0.000). At the same time, a negative correlation between vitamin D and BMI (ρ=-0.517, p<0.000); cholesterol (ρ=-0.560, p<0.001), and triglycerides(ρ=-0.529, p<0.005) was observed. Also, a moderate correlation between erectile dysfunction severity degree and testosterone levels (ρ=0.544) was also detected, and the same severity parameter of erectile dysfunction correlates negatively with cholesterol levels (ρ=-0.534). In its turn, the testosterone level correlates negatively with other biochemical indices: cholesterol (ρ=-0.694) and triglycerides (ρ=-0.670).
Vitamin D level reduction, concomitantly with decreased testosterone and increased cholesterol, contributes to the development and maintenance of erectile dysfunction, more probably through endothelial mechanisms. The assessment of vitamin D values can be used as an independent marker in erectile dysfunction assessment. Thus, one of the diagnostic tests recommended for erectile dysfunction should be the determination of the vitamin D serum level.
Evaluation of Dental Health in Terminally Ill Patients
Authors: Kumari Minti ,   Department of Public Health Dentistry, Patna Dental College and Hospital, Patna, India, Kumar Tanoj ,   Department of Oral Pathology and Microbiology, Patna Dental College and Hospital, Patna, India,   Dr. Tanoj Kumar, Professor and Head,Department of Oral Pathology and Microbiology,Patna Dental College and Hospital, Patna, Bihar E-mail: drtanojkumar@rediffmail.com Phone: +919431647732, Rai Shweta ,   Department of Oral and Maxillofacial Surgery, Buddha Institute of Dental Sciences and Hospital, Kankarbagh, Patna, India, Rai Anurag ,   Department of Orthodontics, Patna Dental College and Hospital, Bankipore, Patna, India, Sultana Rafat ,   Lifeline Dental Care, Gaya, Patna, India, Priya Leena ,   Department of Oral Medicine And Radiology, Buddha Institute of Dental Science and Hospital, Patna, India
Published: November 2022

Dental health plays an imperative role in the general health and well-being of an individual. Terminally ill patients due to a compromised immune response are susceptible to a wide array of oral complications, which may affect their ability to speak and chew, leading to malnutrition.
The present study was conducted to evaluate dental health and various oral manifestations in terminally ill patients.
One hundred twenty terminally ill patients hospitalized with diseases of the respiratory tract, gastrointestinal tract, circulatory system, liver, and endocrinal disorders were included in the study. The evaluation of oral manifestations and their prevalence was done by a single examiner. The oral health was evaluated according to symptoms exhibited by the patients and clinical presentation.
Of the patients included in the study, 78 were male, and 42 were female. All the individuals were adults between 25 to 55 years of age. Out of 120 admitted terminally ill patients, 27 subjects had respiratory diseases, 17 had gastrointestinal disorders, 5 had disorders of the circulatory system, 39 had liver disorders, and 32 had endocrine disorders.
A need for added comprehension is mandatory to link the inter-relationships between dentistry and medicine to further perk up the management of the overall health of patients, which will further reinforce the partnership between dental and medical communities.
Mental Health Disorders During the COVID-19 Outbreak in Cyprus
Authors: Neophytos Stylianou ,   International Institute for Compassionate Care, Nicosia, Cyprus,   Dr. Stylianou Neophytos International Institute for Compassionate Care 24, Ilia Papakyriakou, Nicosia, 2415, Cyprus E-mail: n.stylianou@symponesi.org, Samouti Gregoria ,   International Institute for Compassionate Care, Nicosia, Cyprus, Samoutis George ,   International Institute for Compassionate Care, Nicosia, Cyprus
Published: November 2022

Cyprus has been affected by COVID-19 since March 2019. With a case fatality rate of 2.6% (until June 2020) and the social isolation measures enforced on the population, the population’s mental health has been affected. We aimed to assess the mental health burden of the Cypriot population during the outbreak and to explore the potential influence factors.
Using a web-based cross-sectional survey, we collected data from 216 volunteers regarding demographic data, COVID-19-related knowledge, generalized anxiety disorder (GAD), and major depressive symptoms. The overall prevalence of GAD and major depressive symptoms of the public were 13.89% and 8.33%, respectively. No demographic had shown any statistical significance with GAD. The younger age group of the study showed a statistically significant association with major depressive symptoms when compared to the adult population in both univariate and multivariable analyses.
Our study identified a mental health burden of the Cypriot population, especially the younger age groups. As part of the preparedness for situations as the one we are experiencing and the future impact the pandemic may have on society, interventions should be focused on vulnerable groups of the population to alleviate the psychosocial effects.
The Role of MDR1 (C3435T) Gene Polymorphism in Patients with Chronic Obstructive Pulmonary Disease Associated with Type 2 Diabetes Mellitus
Authors: Chernetska Natalia Vasylivna ,   Department of Internal Medicine and Infectious Diseases, Higher State Educational Establishment of Ukraine “Bukovinian State Medical University”, Chernivtsi, Ukraine,   Natalia Vasylivna Chernetska Higher State Educational Institution of Ukraine “Bukovinian State Medical University”Theatrical square, 2, Chernivtsi, 58002, Ukraine Phone: +380669031949 E-mail: chernetskanataliia@ukr.net, Stupnytska Hanna Yaroslavivna ,   Department of Propaedeutic of Internal diseases, Higher State Educational Establishment of Ukraine “Bukovinian State Medical University”, Chernivtsi, Ukraine, Fediv Oleksandr Ivanovich ,   Department of Internal Medicine and Infectious Diseases, Higher State Educational Establishment of Ukraine “Bukovinian State Medical University”, Chernivtsi, Ukraine
Published: November 2022

Chronic obstructive pulmonary disease is a multifactorial disease characterized by gene-gene interaction as well as environmental effects. The incidence of type 2 diabetes mellitus is proved to be higher in the presence of chronic obstructive pulmonary disease than in the case of its absence.
We aimed to study the genotypes of MDR1 (C3435T) gene polymorphism and its relationship with clinical, instrumental, and laboratory parameters in chronic obstructive pulmonary disease associated with type 2 diabetes mellitus.
All the patients were divided into two groups. The first group included 53 patients with chronic obstructive pulmonary disease, and the second group included 49 patients with chronic obstructive pulmonary disease with comorbid type 2 diabetes mellitus. The COPD assessment test (CAT), 6-minute walk test, BODE integral index, spirometry, and bioimpedansometry were used for examination. Lipid spectrum, carbohydrate metabolism, endothelial functional status, leptin, adiponectin, and serum levels were also determined by means of enzyme immunoassay.
Our study results showed no significant difference between the genotypes of the control group of healthy individuals and patients with chronic obstructive pulmonary disease and comorbid type 2 diabetes mellitus. Though, a certain association of this gene polymorphism with clinical findings by CAT-test, specific parameters of carbohydrate (fasting glucose) and lipid metabolism (total cholesterol and low-density cholesterol lipoproteins), endothelial functional state (nitrate/nitrite level) with the minor allele T available was found.
Contribution of an Early Internal Medicine Rotation to the Clinical Reasoning Learning for Young Residents
Authors: Sovaila Silvia ,   Internal Medicine Department, Civil Hospital, University Hospital of Strasbourg, Strasbourg, France,   Silvia Sovaila, MD, Internal Medicine Department, Hôpitaux Universitaires de Strasbourg, France. E-mail: silvia.sovaila@internist.ro, Purcarea Adrian ,   Internal Medicine Department, University Hospital Strasbourg, Strasbourg, France, Froissart Antoine ,   Internal Medicine Department, Créteil, Assistance Publique – Hôpitaux de Paris, France, Ranque Brigitte ,   Vascular Medicine Department and Reference Center for Rare Vascular Diseases, Hôpital Européen Georges Pompidou, Assistance Publique – Hôpitaux de Paris, France, Kieffer Pierre ,   Internal Medicine Department, Mulhouse hospital, Mulhouse, Andres Emmanuel ,   Internal Medicine Department, University Hospital Strasbourg, Strasbourg, France, Goujard Cecile ,   Internal Medicine Department, Bicêtre Hospital, Assistance Publique – Hôpitaux de Paris, France, Weber Jean-Christophe ,   Internal Medicine Department, Civil Hospital, University Hospital of Strasbourg, Strasbourg, France, Bergmann Jean-François ,   Internal Medicine Department, Hôpital Lariboisiere, Assistance Publique – Hôpitaux de Paris, France, Gayet Stephane ,   Internal Medicine Department, Hôpital Timone, Marseille, France, Granel Brigitte ,   Internal Medicine Department, Marseille University Hospitals, Marseille, France, Bourgarit Anne ,   Internal Medicine Department, University Hospital Strasbourg, Strasbourg, France
Published: November 2022

Clinical reasoning is the cornerstone of medical practice, and achieving this competence depends on a large number of factors. Internal medicine departments provide junior doctors with plentiful and varied patients, offering a comprehensive basis for learning clinical reasoning.
In order to evaluate the usefulness of an early rotation at internal medicine departments, we compared, via script concordance tests, the evolution of residents’ clinical reasoning after an initial internal medicine rotation compared to rotations through other medical specialties.
Twenty-two residents were tested after six months of their internal medicine rotation and compared to twenty-five residents that had the first rotation in another specialty (control). We showed a significant difference in the improvement of the script concordance tests scores (p=0.015) between the beginning and the end of their first rotation between the internal medicine and the control groups, and this implies the lower improvement of clinical reasoning skills and spontaneous learning slope of the junior doctors in other departments.
Protracted course of chemical meningitis following posterior fossa epidermoid cyst excision – A case report
Authors: Ehrlich Adin M. , Larkin Michael Benjamin , English Collin William , Shetty Arya , Gupta Mayuri , Nouri Shervin Hosseingholi , Lu Hsiang-Chih , Mandel Jacob J. , Patel Akash J. 
Published: November 2022

Background:
Chemical meningitis, a subtype of aseptic meningitis, as a complication of posterior fossa surgery is not a rare complication. However, the description of a severe protracted course following the surgical resection of an epidermoid cyst has not been described in the current literature. Chemical meningitis is thought to be associated with a hyperreactive inflammatory response, mediated in part by interleukin (IL)-10, IL-1β, and tumor necrosis factor-α, to the postoperative keratin debris from the spontaneous leakage or surgical release of epidermoid contents into subarachnoid spaces, which ultimately can result in patient symptoms of meningitis and hydrocephalus. Often, this remains mild and the recommended management includes a short course administration of corticosteroids.

Case Description:
The authors report such a case in a patient who underwent a redoresection for a fourth ventricular epidermoid cyst. Postoperatively, the patient returned several times with symptoms of meningitis and hydrocephalus requiring multiple hospitalizations in the ensuing months. The patient required emergent cerebrospinal fluid diversion, further posterior fossa exploration and an extended high-dose corticosteroid treatment regimen.

Conclusion:
The authors summarize the current understanding of the biochemical processes involved for the rare presentation of postoperative chemical meningitis.
Evaluation of the changes in middle cerebral artery flow velocity related to different positions of patients during posterior fossa surgery
Authors: Kanan Rajesh , Sarna Rashi , Bharti Neerja , Panda Nidhi Bidyut , Chauhan Rajeev , Singh Nidhi , Luthra Ankur , Karthigeyan Madhivanan 
Published: November 2022

Background:
This is a prospective observational study to evaluate the changes in middle cerebral artery flow velocities and cerebral perfusion pressure in the various positions used for posterior cranial fossa surgery and to correlate these changes with postoperative recovery characteristics and complications.

Methods:
Sixty patients were included in the study – 33 patients with CPA tumors were placed in the supine with head tilt position and the rest 27 with tumors in other locations of posterior fossa were placed in the prone position. The primary aim was to study the changes in middle cerebral artery blood flow velocity related to various positions of the patients used during posterior fossa surgery. The secondary aim was to compare the changes in pulsatility index, resistance index, and effective cerebral perfusion pressure in different position and to correlate these findings with postoperative recovery and the complications associated with these positions.

Results:
The systolic and mean flow velocities were higher in the supine with head tilt group than the prone group after positioning and post repositioning, but these values were within normal limits, and the changes with positioning from baseline were comparable between the groups. Furthermore, these changes did not affect the effective cerebral perfusion pressure or the outcomes of the patients.

Conclusion:
The current results do not determine whether the supine with head tilt position is better than the prone position during posterior fossa surgery.