bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evidence for an Expanded Hypertension Care Cascade in Low- and Middle-Income Countries: A Scoping Review
Authors: Peters Michael , Noonan Caitlin M. , Rao Krishna D. , Edward Anbrasi , Alonge Olakunle O. 
Published: March 2022

Abstract
Background
With nearly 90% of annual hypertension-related deaths occurring in low- and middle-income countries (LMICs), there is an urgent need to measure the coverage of health services that effectively manage hypertension. However, there is little agreement on how to define effective coverage and the existing hypertension care cascade (hypertension prevalence, percent aware, percent treated, and percent controlled) does not account for the quality of care received by patients. This study reviews definitions of effective coverage and service quality for hypertension management services and proposes an expanded hypertension care cascade to improve measurement of health systems performance.
Methods
A systematic scoping review of literature published in six electronic databases between January 2000 and October 2020 identified studies that defined effective coverage of hypertension management services or integrated dimensions of service quality into population-based estimates of hypertension management. Findings informed an expanded hypertension care cascade from which quality-adjusted service coverage can be calculated to approximate effective coverage.
Results
The review identified 20 relevant studies, including 8 that defined effective coverage for hypertension management services and 12 that reported a measure of service quality in a population-based study. Based on commonly reported barriers to hypertension management, new steps on the proposed expanded care cascade include (i) population screened, (ii) population linked to quality care, and (iii) population adhering to prescribed treatment.
Conclusion
There is little consensus on the definition of effective coverage of hypertension management services, and most studies do not describe the quality of hypertension management services provided to populations. Incorporating aspects of service quality to the hypertension care cascade allows for the calculation of quality-adjusted coverage of relevant services, enabling an appropriate measurement of health systems performance through effective coverage.
Acceptance, Utilization and Factors Associated With Immediate Postpartum Intrauterine Contraceptive Devise Among Mothers Delivered in Public Health Facilities of Hawassa City, Sidama Regional State, Ethiopia.
Authors: Deneke Yemisrach Shiferaw , Jisso Meskerem , Fantahun Selam , Eshetu Betelhem , Assefa Abiyu Ayalew , Gebretsadik Achamyelesh 
Published: March 2022

Abstract
Background: Immediate Postpartum intra uterine contraceptive device (IPPIUCD) placement within 10minute after delivery is a safe and effective method when provided after comprehensive counseling. Studies on its acceptance and utilization are scarce in study area. This study aims to assess the acceptance and utilization of IPPIUCD.Methods: A cross sectional study was conducted among mothers delivered in the public health facilities in Hawassa city administration. EPI-Data version 7.2 was used for data entry and STATA 14 for analysis. To measure association a binary logistic regression and multivariable logistic regression model were used. Statistical significance was determined at p value of 0.05 with 95% confidence interval.Result: The mean (± SD) age of study participants was 25 years (±4.5). Acceptance and utilization of immediate post-partum IUCD were 64(16.4%) & 39(10%) respectively. Counseling about IPPIUCD, Attitude, plan to have another child, and birth Interval were associated with acceptance of immediate PPIUCD while husband support for family planning use, delivery time and number of children had significant association with utilization of immediate PPIUCD. Conclusion: The study found a relatively low proportion of acceptor and utilizer of immediate post-partum IUCD in the study area. To improve the acceptance and utilization of immediate PPIUCD among mothers, all stake holders concerned with family planning need to mitigate and promote the challenges and facilitating factors respectively.
Reconfigurable Graphene-Based Metamaterial Polarization Converter for Terahertz Applications
Authors: Mabrouk Ahmed Mosaad , Donkol A. A. , Seliem Asmaa G. 
Published: March 2022

Abstract
This paper suggests a high gain polarization converter using a graphene-based metamaterial array. The graphene-based metamaterial polarization converter is a rectangular array that consists of 20 periodic unit-cell elements. Each graphene-based metamaterial unit-cell element consists of a rectangular patch with four triangular-shaped graphene parts at its four corners. The rectangular patch with the four graphene parts are placed over a rectangular substrate backed with a perfect electric conductor (PEC) and has a relative permittivity of εsub = 3.38. The metamaterial characteristics of the proposed graphene-based metamaterial unit-cell element are obtained over a wide range of frequencies of 0.7 THz ranging from 1.5 THz to 2.2 THz. The graphene-based metamaterial array is placed over a linear polarized slot antenna that operates at 1.8 THz with a maximum gain of 5.5 dBi. The linearly polarized wave that radiated from the slot antenna can be converted into a reconfigurable right-handed circular polarization (RHCP) or Left-handed circular polarization (LHCP) according to the biasing states of the graphene parts. Moreover, the operating -10 dB B.W of the slot antenna is increased to 22.2%, and the gain is enhanced to 8 dBi at the same operating frequency. A reconfigurable polarization conversion for the slot antenna can be obtained over a wide 3dB axial ratio (AR) B.W from 1.75 THz to 1.92 THz (20% 3dB B. W).
Fear and Anxiety related to Covid-19 pandemic may predispose to perinatal depression
Authors: Orsolini Laura , Pompili Simone , Mauro Antonella , Salvi Virginio , Volpe Umberto 
Published: March 2022

Abstract
Purpose. The COVID-19 pandemic situation significantly affected the mental health of the general and clinical population including that of pregnant and puerperal women due to lack of access to healthcare, social isolation, sleep loss, feelings of fear and uncertainties. However, few studies investigated which COVID-19-related psychopathological determinants may predispose to perinatal depression. The aim of this study was to evaluate the impact of COVID-19 related anxiety and fear on perinatal depression. Methods. We retrospectively screened 184 perinatal outpatients afferent to Perinatal Mental Health outpatient service, during March 2020-March 2021, by using the Edinburgh Postnatal Depression Scale (EPDS), the Fear of COVID-19 (FCV-19-S) and the Coronavirus Anxiety Scale (CAS). Results. The mean EPDS score was 9.0 (SD=5.3), experiencing a clinically relevant perinatal depression in 45.7% of the sample. The mean FCV-19-S score was 15.0 (SD=6.2) and CAS was 1.7 (SD=2.8). Linear regression analyses demonstrated that FCV-19-S (F(1,68)=12.218, R2=0.152, p<0.001) and CAS scores (F(1,68)=10.278, R2=0.131, p=0.002) statistically significantly predicted EPDS total scores. A positive correlation was reported between FCV-19-S and EPDS (r=0.390, p<0.001) and between CAS and EPDS (r=0.362, p<0.001). Conclusion. COVID-19 pandemic with its subsequent isolation, quarantine and lockdown might determine increased levels of anxiety and fear, particularly among women in their perinatal period who may experience a deprivation of their normal sources of family and social support and, hence, experience psychological distress, even in those women without a previous psychiatric history. Further preventive and screening strategies should be implemented in order to early identify at-risk pregnant and puerperal women during the COVID-19 pandemic.
The Complete Cloroplast Genomes of Tetrastigma Hemsleyanum (Vitaceae) from Different Regions of China: Molecular Structure, Comparative Analysis and Development of DNA Barcodes for its Geographical Origin Discrimination
Authors: Dong Shujie , Zhou Manjia , Zhu Jinxing , Wang Qirui , Ge Yuqing , Cheng Rubin 
Published: March 2022

Abstract
Background Tetrastigma hemsleyanum is a valuable traditional Chinese medicinal plant widely distributed in the subtropical areas of China. It belongs to the Cayratieae tribe, family Vitaceae, and exhibited significant anti-tumor and anti-inflammatory activities. However, obvious differences were observed on the quality of T. hemsleyanum root from different regions, requiring the discrimination strategy for the geographical origins. ResultThis study characterized five complete chloroplast (cp) genomes of T. hemsleynum samples from different regions, and conducted a comparative analysis with other representing species from family Vitaceae to reveal the structural variations, informative markers and phylogenetic relationships. The sequenced cp genomes of T. hemsleyanum exhibited a conserved quadripartite structure with full length ranging from 160,124 bp of Jiangxi Province to 160,618 bp of Zhejiang Province. We identified 112 unique genes (80 protein-coding, 28 tRNA and 4 rRNA genes) in the cp genomes of T. hemsleyanum with highly similar gene order, content and structure. The IR contraction/expansion events occurred on the junctions of ycf1, rps19 and rpl2 genes with different degrees, causing the differences of genome sizes in T. hemsleyanum and Vitaceae plants. The number of SSR markers discovered in T. hemsleyanum was 56-57, exhibiting multiple differences among the five geographic groups. Phylogenetic analysis based on conserved cp genome proteins strongly grouped the five T. hemsleyanum species into one clade, showing a sister relationship with T. planicaule. Comparative analysis of the cp genomes from T. hemsleyanum and Vitaceae revealed five highly variable spacers, including 4 intergenic regions and one protein-coding gene (ycf1). Furthermore, five mutational hotspots were observed among T. hemsleyanum cp genomes from different regions, providing data for designing DNA barcodes trnL and trnN. The combination of molecular markers oftrnL and trnN clustered the T. hemsleyanum samples from different regions into threegroups, thus successfully separating specimens of Sichuan and Zhejiang from other areas. Conclusion Our study obtained the chloroplast genomes of T. hemsleyanum from different regions, andprovided a potential molecular tracing tool for determining the geographical origins of T. hemsleyanum, as well as important insights into the molecular identification approach and and phylogeny in Tetrastigma genus and Vitaceae family.
Limited Utility in Using Frailty Scores Based on Electronic Health Record Data to Predict Acute Outcomes of Major Lung Resection
Authors: Attaar Mikhail , Lee Andy , Lee Sang Mee , Huisingh-Scheetz Megan , Ferguson Mark 
Published: March 2022

Abstract
Background: Frailty is a risk factor for adverse outcomes after lung resection, but few centers routinely assess frailty preoperatively. We evaluated whether frailty scores can be calculated using extant electronic health record (EHR) data and whether scores are associated with acute lung resection outcomes. Methods: A retrospective review of patients who underwent major lung resection for cancer 1995-2014 was performed to calculate four EHR-based frailty indices: modified frailty index (mFI-5), prognostic nutritional index (PNI), and two laboratory frailty indices (FI-Lab and FI-Laboratory). Scores were generated if >70% of EHR values were present for a patient within six months of surgery. The association between frailty scores and surgical complications was assessed using multivariable logistic regression.Results: We included 496 patients (50.3% female, mean age 65.8 ± 1.0 years). The mFI-5 score could be calculated for all patients. PNI, FI-Lab and FI-Laboratory scores could be calculated for only 33.4%, 5.6% and 38.5% of patients, respectively. Adjusted odds ratios were calculated only for the mFI-5 and demonstrated that scores >1 were significantly associated with pulmonary complications (p = 0.002) and any complication (p = 0.004).Conclusions: Among four EHR-based frailty indices evaluated, only the mFI-5 could be consistently calculated. The mFI-5 was an independent predictor of pulmonary and overall complications. Further investigation of this and other measures of frailty is necessary in order to more robustly predict surgical outcomes.
Planning for groundwater management using Visual MODFLOW Model and Multi-Criteria Decision Analysis, West- West Minia, Egypt.
Authors: morsy samah mahmoud 
Published: March 2022

Abstract
This study presents a planning model to assist decision-makers in implementing proposed sustainable development policies based on the government's development schemes. It focuses on the exploitation of groundwater from the Eocene aquifer in the West-West Minya region in the Western desert of Egypt as one of the new development areas. The visual MODFLOW model is applied to serve as a base model for the study area's local modeling and assess the impact of operating scenarios on the groundwater aquifer. An optimal scenario for groundwater sustainability is achieved by considering the water meter consumption in the newly reclaimed area with a value of 6 m3/d for each acre to irrigate 3953.68 acres. The results reveal a lower decline in groundwater levels than the other proposed scenarios, and dynamic groundwater levels reached a steady-state after an estimated 9700 days. The GIS Multi-Criteria Analysis Model is used to assess the impact of groundwater deficiency as a result of reclamation. Results of the groundwater model are merged as input layers in Multicriteria Decision Analysis, which include groundwater salinity, groundwater levels, aquifer transmissivity, and aquifer storativity. The prospective groundwater zones are categorized into Most suitable (1584 sq km, 9.9 %), Suitable (4592 sq km, 28.7%), Good (4784 sq Km, 29.9%), Moderate (1488 sq Km, 9.3%) and Unsuitable (3552 sq Km, 22.2%). It is recommended to optimize levels of groundwater withdrawal from the current or future drilling wells to achieve a balance between the use and the protection of water potential.
Assessment of deep aquifer development and its implications in granitic terrain using isotopes and chemistry
Authors: Reddy Venkat D , Kumar Devender , Kumar B. Kiran , Reddy S. Kiran Kumar , Shashidhar D. 
Published: March 2022

Abstract
This study is conducted in the Precambrian granitic terrain, to demonstrate the presence of the multi-aquifer system and examine the inter-communications between them. Distinct hydrochemical characters of the groundwater from shallow (~ 100 m) and deep (~ 400 m) wells, signifies their independent and unconnected nature initially. Hydrochemistry of deep groundwater is approximately constant (either Ca-Na-Cl or Ca-Na-Cl-SO4 type of water) during January 2015 to June 2016. Repeated carbon-14 measurements during the same period show the 14C activity of about 35 to 85 pMC (residence time about 3 to 8 ky BP). However, as a result of excess rainfall during 2016, hydrochemical facies of deep groundwater changed initially to Na-Ca-SO4-Cl and subsequently stabilised at Ca-Na-HCO3-Cl type with a drastic reduction in Cl and increased HCO3 and NO3 concentrations, while the 14C activity turned out to be to 100 pMC (modern age). These changes are attributed to ingression of fresh water into the deep aquifer, after paleo-groundwater depleted due to prolonged drought conditions along with the over-exploitation of limited potential deep aquifer. These drought and over-exploitation situations potentially improved the migration potential of fresh water to the deep aquifer and led to enhancing the groundwater recharge during the excess rainfall years. This brings a new perspective to the hydrogeological dynamics between shallow and deep groundwater. A conceptual model is proposed to explain the observed phenomenon. This study also suggests that, under climate driven drought conditions, deep aquifers could act as emergent groundwater resource to meet the water demands amid population growth.
Effect of Adjunct Tele-Yoga on Clinical Status at 14 Days in Hospitalized mild and Moderate COVID-19 Patients: a Randomized Controlled Trial
Authors: Majumdar Vijaya , K Manjunath N , R Nagarathna , Panigrahi Suryanarayan , Kanchi Muralidhar , Sahoo Sarthak , Nagendra Hongasandra R , Giridharan Adithi , Reddy Mounika , Nayak Rakshitha 
Published: March 2022

Abstract
Background: We tested if tele-yoga intervention could aid in better clinical management for hospitalized patients with mild to moderate COVID-19 when complemented with the standard of care.Methods: This was a randomized controlled trial conducted at the Narayana Hrudalaya, Bengaluru, India on hospitalized patients with mild to moderate COVID-19 infection, enrolled between May 31st and July 22, 2021. Patients (n=225) were randomized in 1:1 ratio [adjunct tele-yoga (n = 113), or standard of care (n = 112)]. Adjunct yoga group received intervention in tele-mode within 4 hours post-randomization until 14 days along with the standard of care. The primary outcome was clinical status at 14th-day post-randomization assessed with a 7-category ordinal scale. The trial included 11 secondary outcomes, including 28-day mortality.Results: As compared with standard of care alone, the proportional odds of having a higher score on the seven-point ordinal scale at day 14 was ~1.9 for the adjunct tele-yoga group (95% CI, 1.18-3.18). CRP and LDH levels were comparatively reduced in the adjunct tele-yoga group 5th day post-randomization. CRP reduction was also observed as a potential mediator for the improvement of clinical outcomes in the adjunct tele-yoga group. There were no significant differences between the treatment groups concerning the duration of hospitalization, all-cause mortality at day 28; log-rank P = 0.144, and other outcomes.Conclusion: The observed clinically relevant outcomes in COVID-19 patients at day 14 contest the use of tele-yoga as a complementary treatment in hospital settings.
Polarization and Wide Incident Angle Insensitive Metal Free Superwideband Absorber For Terahertz and Infrared Spectrum
Authors: SINGHAL SARTHAK 
Published: March 2022

Abstract
A circular slot loaded octagonal metal free graphite based absorber for superwideband applications at terahertz and infrared spectrum is proposed. The absorber comprises a circular slot loaded octagonal graphite slab at the top layer, silicon dioxide as substrate and square graphite slab as the bottom layer. This absorber is operating over a frequency spectrum of 6 THz to more than 80 THz (ratio bandwidth of > 12:1 and fractional bandwidth of > 172.093%) for absorption more than 90% with unity peak absorption. The absorber dimensions are 5 µm × 5 µm × 7.04 µm. The thickness of the substrate is only ∼ λo/26 and the periodicity of absorber is ∼ λo/10 at 6 THz. The performance of the absorber is found to be insensitive to changes in polarization angle (Φ). Furthermore, the performance of the absorber is observed to be unaffected by incident angle (θ) variations from 0o to 60o. The metal-free geometry along with insensitiveness to Φ and 0o ≤ θ ≤ 60o makes the proposed absorber suitable for compact terahertz/infrared micro/nanoscale systems.
Lymphocytes in Tumor-Draining Lymph Nodes Co-Cultured with Autologous Tumor Cells for Adoptive Cell Therapy
Authors: Okamura Kazumi , Nagayama Satoshi , Tate Tomohiro , Chan Hiu Ting , Kiyotani Kazuma , Nakamura Yusuke 
Published: March 2022

Abstract
Background
Tumor-draining lymph nodes (TDLNs) are primary sites, where anti-tumor lymphocytes are primed to tumor-specific antigens and play pivotal roles in immune responses against tumors. Although adoptive cell therapy (ACT) using lymphocytes isolated from TDLNs were reported, characterization of immune activity of lymphocytes in TDLNs to tumor cells was not comprehensively performed. Here, we demonstrate TDLNs to have very high potential as cell sources for immunotherapy.
Methods
Lymphocytes from TDLNs resected during surgical operation were cultured with autologous-tumor cells for 2 weeks and evaluated tumor-reactivity by IFNγ ELISPOT assay. We investigated the commonality of T cell receptor (TCR) clonotypes expanded by the co-culture with autologous tumor cells with those of tumor infiltrating lymphocytes (TILs).
Results
We found that that TCR clonotypes of PD-1-expressing CD8+ T cells in lymph nodes commonly shared with those of TILs in primary tumors and lymphocytes having tumor-reactivity and TCR clonotypes shared with TILs could be induced from non-metastatic lymph nodes when they were co-cultured with autologous tumor cells.
Conclusion
Our results imply that tumor-reactive effector T cells were present even in pathologically non-metastatic lymph nodes and could be expanded in vitro in the presence of autologous tumor cells and possibly be applied for ACT.
Trends and Research features on Greenhouse gas emission from Rice production: Review based on bibliometric analysis
Authors: Sossa Coffi Leonce Geoffroy , Sanogo Souleymane , Naab Jesse B. , Sintondji Luc O. 
Published: March 2022

Abstract
Rice production is facing the veritable challenge of meeting the still world growing population needs while minimizing its consequence in the environment. Greenhouse from rice production has become a great concern and a core of a lot of research during the last years. The main aim of the study was to explore the research trend of GHG emission from rice production from multiple perspectives and provide references and suggestions for the future development direction over the period 1991–2020. A bibliometric analysis was conducted using the Scopus database and the sample included 2535 articles. The methodology was based on descriptive analysis, Co-Occurrence Analysis, Factorial analysis, Word dynamic over time, and Author’s keyword analysis over time. The results indicate a remarkable increase in the number of articles published on this topic mainly in the journals ‘Agriculture’, ‘Ecosystems’, and ‘Environment’. the main authors were Conrad R. and Wassmann R. In terms of a number of articles, very few were related to African countries and China, Japan and India were the main contributors. Keywords co-occurrence analysis showed that Rice, methane, and carbon dioxide are the core keywords of the network. The multiple factorial analysis pointed out the relationship between management practices, Carbone dioxide emission, and rice production. Different authors’ keywords during the three decades have been used and during the last decade included Global Warming Potential, Greenhouse Gas and Climate Change. The findings of this review can help researchers and scholars by providing an overview of worldwide research in this field.