bluuebunny/crossref_metadata_2025_split huggingface dataset:
Predicting 90-day readmission for patients with heart failure: a machine learning approach using XGBoost
Authors: Sheng Song , Huang Ye 
Published: September 2022

Abstract
Background Heart failure (HF) is one of the most prevalent diseases in China and worldwide with poor prognosis. A prognostic model for predicting readmission for patients with HF could greatly facilitate risk stratification and timely identify high-risk patients. Various HF prediction models have been developed worldwide; however, there is few prognostic models for HF among Chinese populations. Thus, we developed and tested an eXtreme Gradient Boosting (XGBoost)model for predicting 90-day readmission for patients with HF.
Methods Clinical data for 1,532 HF patients retrospectively admitted to Zigong Fourth People’s Hospital in Sichuan Province from December 2016 to June 2019 were used to develop and test two prognostic models: XGBoost and logistic models. The least absolute shrinkage and selection operator (LASSO) regression method was applied to filter variables and select predictors. The XGBoost model tuning was performed in a 10-fold cross validation and tuned models were validated in test set (7:3 random split). The performance of the XGBoost model was assessed by accuracy (ACC), kappa, area under curve (AUC) and other metrics, and was compared with that of the logistic model.
Results systolic blood pressure, diastolic blood pressure, type of HF, mean corpuscular hemoglobin concentration, total cholesterol were screened out as predictors through LASSO regression. In training set, we optimized four major parameters, max depth, eta, nrounds and early stopping rounds with optimal values of 6, 0.5, 1000 and 5 for XGBoost. In test set, we obtained a ACC of 0.99 with kappa of 0.98 and the AUC, sensitivity and specificity achieved were of 1.00, 1.00 and 0.99 in the XGBoost model, which has significantly higher prediction performance than the logistic model.
Conclusion The XGBoost model developed in our study had excellent prediction performance in test set and the model can contribute to the assessment of 90-day readmission risk for patients with HF in Chinese population.
Socio-Cultural and Economic Determinants of Latrine Ownership and Unitilisation: A Community-Based Survey in Bole District of Ghana
Authors: Nanyim Jonathan K. , Mutaru Abdul-Manaf , Gbeti Collins , Issahaku Abdul Rahaman , Abubakari Abdulai , Wumbei Abukari 
Published: September 2022

Abstract

Latrine ownership and utilisation is an integral part of the Community-Led Total Sanitation (CLT) implementation process. This study assessed ownership and utilization of latrine in selected Open Defecation (OD) and Open Defecation Free (ODF) communities within the Bole district. A community-based cross-sectional survey design and quantitative approach were employed in this study. Simple random sampling was used to select 166 respondents from 20 OD and ODF communities. Data collection was done using structured questionnaire. Data was analysed descriptively with frequencies, percentages, means and standard deviations. At the bivariate and multivariate levels, the chi-square association test and a binary logistic regression analysis were conducted respectively at 95% confidence levels. The proportion of latrine ownership and utilization were 22.3% and 6.6% respectively in this study. Household subjective norms, cultural and economic factors were found to be influencing latrine ownership and utilization. Educational qualification and awareness on CLTS in the communities are determinants of latrine ownership while belief in household subjective norms is a true predictor of latrine utilization. Therefore, effective measures, including education, sensitization, and implementable by-laws/community regulations must be put in place to propel latrine ownership and utilisation and reduce open defecation to the barest minimum.
Structure-Decidable structure-examples of decidable structures with proof-some examples of undecidable structures
Authors: sheikhaleslami zahra 
Published: September 2022

Abstract
In this paper, decidability of the structures of real, rational, integer and natural numbers will be studied in different languages.
Decidability or undecidability of mathematical structures is one of the fundamental and sometimes very difficult problems of mathematical logic, where several examples of problems in this field are still open and unresolved even after decades. One of the goals of Mathematical Logic is the axiomatization of mathematical theoriesTarski has proved the decidability of the theory of real and complex numbers in the language of addition and multiplication, and it is proved that theories of natural, integer, and rational numbers, in the language of addition and multiplication, are undecidable (Theorems of Gödel and Robinson).
We will proof The following problemes: The Main Problem 1: ⟨Q; ⊑⟩ is decidable? Problem 2: an explicit axiomatization for ⟨Z; x⟩? and we will study boolean algebras. Boolean algebras are famous mathematical structures. Tarski showed the decidability of the elementary theory of Boolean algebras.In this paper, we study the different kinds of Boolean algebras and their properties. And we present for the first-order theory of atomic Boolean algebras a quantifier elimination algorithm. The subset relation is a partial order and indeed a lattice order, And I will prove that the theory of atomic Boolean lattice orders is decidable, and furthermore admits elimination of quantifiers. So the theory of the subset relation is decidable. And we will study decidability of atomlss boolean algebra.
Effect of COVID-19 Period on Tuberculosis Treatment Success; a Mixed Methods Study among Tuberculosis patients at Jinja Regional Referral Hospital.
Authors: james higenyi , Katamba Achilles 
Published: September 2022

Abstract
Introduction
Before the COVID-19 pandemic, over 4000 people were dying from TB every day. TB is still a major public health threat globally, but the TB epidemic may be exacerbated by the COVID-19 pandemic. The lockdown in response to the pandemic and the events related to it can have an adverse epidemiologic impact on TB treatment outcome through its effect on poverty, and dietary intakes.
Objectives
Therefore, this study during COVID-19 would determine the effect of COVID-19 period on Tuberculosis Treatment success among TB patients.
Methods
Sequential explanatory mixed methods was used. A retrospective cohort study was employed for the quantitative component to determine the association between COVID-19 period and Tuberculosis treatment success among Tuberculosis Patients at Jinja Regional Referral Hospital. A data abstraction sheet was used to extract the required data from the TB treatment registers. Treatment outcomes was dichotomized as successful treatment outcome and poor treatment outcome. Modified possion regression was used to explore associations between treatment outcome and other independent variables.
A qualitative study with a phenomenology approach was adopted to get an in-depth understanding to the barriers and facilitators to treatment success during the COVID era among Tuberculosis Patients at Jinja Regional Referral Hospital. The lived experience of the TB patients who had participated in the quantitative component was captured. Data from audio recordings was transcribed and analyzed using a deductive thematic analysis to explore barriers and facilitators.
Results
There was no significant effect of COVID-19 Period on TB treatment Success (aRR=1.04: 95% CI 0.78-1.38). In addition, sex, HIV status, age, distance from the health facility, disease classification and treatment mode were not significantly associated with treatment success. The barrier to treatment success were lack of adequate health care information, fearing the COVID thing in the hospital. Some health workers pointed out that donors failed to support most of the TB activities as government redirected most of its funding to COVID-19 activities and neglected TB services.
The major facilitators were good relationship with health care workers, TB awareness programs, updating of TB guidelines and availability of free drugs and services.
Conclusion
This study did not find a significant effect of COVID-19 period on treatment outcomes. Measures towards alleviating fear and stigma and ensuring financial securities of the patients during the time of health crisis are important for preparedness against future epidemics such as COVID-19.
Differentiation of Heterodera glycines races by metabolomics
Authors: Costa Guilherme Nunes Moreira , Souza Hebréia Oliveira Almeida , Maia Larissa Prado , Martins Mário Machado , Bastos Luciana Machado , Goulart Luiz Ricardo , Ueira-Vieira Carlos 
Published: September 2022

Abstract
The nematode Heterodera glycines is one of the main phytosanitary problems of soybean and the main management strategy is the use of pathogen resistant cultivars. For this, it is necessary to characterize the populations of H. glycines. Race determination schemes present flaws and there is a demand for more practical methods. This study objective was to identify possible target metabolites for the characterization of populations of H. glycines. For this, the metabolic profile of the H. glycines races present in the Brazilian territory was analyzed by High-Performance Gas Chromatography linked to Mass Spectrometry and contrasted with a database. The results showed different metabolites profiles with the potential to be used as indicators of the races determined by the differentiating cultivars method. The concentrations patterns of metabolites found were different among the races analyzed and allow the individualization of each race within a single profile. These findings indicate the possibility of race discrimination based on metabolomics tests. Further investigations may provide fundamental information in the development of new rapid tests for the determination of H. glycines races.
Genome-Wide Identification and Expression Profiling of the FORMIN Gene Family Implies Their Potential Functions in Abiotic Stress Tolerance in Rice (Oryza sativa)
Authors: Li Bin , Du Zhi-Ye , Jiang Nan , He Shan , Shi Yang , Xiao Kai , Xu Li-Jia , Wang Kai-Shun , Wang Xin , Chen Ji , Huang Jin 
Published: September 2022

Abstract

FORMIN proteins, which contain FH1 and FH2 domains, play crucial roles in the growth and development of organisms. However, the functions of FORMINs in rice (Oryza sativa L) remain largely unclear. In this study, a total of 17 FORMIN genes in rice genome were identified and their distribution on chromosomes, gene structure, as well as protein structure was investigated. According to their protein structural and phylogenetic features, these 17 rice FORMIN genes were classified into two distinct subfamilies. Subcellular localization prediction showed that rice FORMINs were located in cytosol, Golgi complex, endoplasmic reticulum, extracellular and vacuole. Protein protein interaction (PPI) prediction results showed that FORMIN protein might answer hormone signals and be involved in cytoskeleton dynamics regulation and cell wall morphology regulation. The gene expression analysis by using qRT-PCR indicated that a number of rice FORMIN genes were induced by auxin/indole-3-acetic acid (Aux/IAA) and abscisic acid (ABA). Importantly, some of the FORMIN genes also exhibited cadmium (Cd) and drought stress responding expression patterns, suggesting that FORMIN genes may play roles in rice while dealing with drough or Cd stress. Overall, our research may shed light on the understanding of the biological functions of rice FORMINs.
Effect of the thermomechanical reprocessing conditions on polypropylene composites based on automotive waste parts: path to a circular economy?
Authors: Garcia-Vazquez Hector , Martinez-Hernandez Harol D. , Trujillo-Barragán Magdalena , Mondragon-Flores Esteban , Rodriguez-Juarez Mario E. , Millan-Malo Beatriz M. , Villada-Villalobos Jhon A. , Rodriguez-Garcia Mario E. 
Published: September 2022

Abstract
This paper is focused on the study of the waste car bumper samples and their transformation by re-extrusion-injection. Car bumpers are formed by crystalline phases of polypropylene (PP), talc, and amorphous ethylene propylene diene monomer (EPDM). The thermal, mechanical, and structural properties of the recycled material strongly depend on the process used for the extrusion and injection. The FWHM of the X-ray diffraction patterns was used to study the recrystallization phenomenon in PP, and the result had a direct correlation with the findings obtained by Differential Scanning Calorimetry (DSC). Remaining micro paint particles from the waste car bumpers involved in the recycled extrusion-injection process affect the mechanical properties, and their size and toughness could affect injection. Removal of these particles could improve the mechanical properties of recycled PP. Automotive parts based on polypropylene can be recycled for the automotive industry by the production of the same kind of products, and even for other field. It proposed a methodology and metrology to know the accurate chemical composition and its relationship with the properties of PP-based materials to find applications in different fields that allow to development of a circular economy framework.
WITHDRAWN: Concurrent Multi-path quantum entanglement routing based on segment routing in quantum hybrid networks
Authors: Zhang Ling 
Published: September 2022

Abstract
In the future, quantum networks will be an important development direction. Quantum networks should be studied in light of quantum's unique physical properties. In quantum networks with limited resources, decoherence will lead to qubits loss, which restricts the time that data qubits can be stored in memory before use. To realize the network function, it is very important to transmit data qubits as quickly as possible. In order to ensure timeliness and make use of entanglement resources as much as possible, this paper proposes a concurrent multi-path entanglement routing scheme based on segment routing for quantum hybrid networks. Compared with single-path routing, this scheme has obvious advantages in traffic diversion, reducing transmission time and providing redundancy.
Prediction of the mechanism of Jin Ling Zi Powder in the intervention of gastric cancer based on transcriptomics and network pharmacology
Authors: Chen Liyao 
Published: September 2022

Abstract
Background
Traditional Chinese medicine (TCM) has unique advantages in alleviating gastric cancer (GC), and Jin Ling Zi Powder is a common drug used in TCM treatment. However, the potential mechanism for its treatment of GC is unclear.
Objective
The purpose of this study is to integrate transcriptomics, network pharmacology and molecular docking to investigate the active components and targets of Jin Ling Zi Powder's intervention in GC and related pathways, in order to provide a basis for further revealing its mechanism of action and developing Jin Ling Zi Powder.
Methods
The potential targets of Jin Ling Zi Powder and GC-related genes were obtained from public database. Potential targets and signaling pathways were identified and visualized through bioinformatics analysis, including protein-protein interaction (PPI), Gene Ontology (GO) functional enrichment analysis, and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis.Subsequently, molecular docking was performed to further validate these findings.
Results
The results showed that potential targets including IL6, PTGS2, MMP9, HMOX1, MYC, CHRM3, TOP2A, CA2, and KCNMA1 were the therapeutic targets of Jin Ling Zi Powder for gastric cancer. The functional enrichment analysis indicate that through synergistically regulating some biological pathway, such as inflammatory response, cellular response to tumor necrosis factor, AGE-RAGE signaling pathway in diabetic complications, TNF signaling pathway, TNF signaling pathway, MicroRNAs in cancer, Pathways in cancer, etc., which have therapeutic effects on gastric cancer. In addition, the molecular docking results showed that the compounds had good binding activity to the action target in vivo.
Conclusion
This study comprehensively describes the potential targets and molecular mechanisms of Jin Ling Zi Powder for the treatment of gastric cancer. It also provides promising avenues for revealing the treatment of diseases by TCM through scientific basis and therapeutic mechanisms.
Role of Postoperative Radiotherapy in Resected Adenoid Cystic Carcinoma of the Head and Neck
Authors: Choi Seo Hee , Yang Andrew Jihoon , Yoon Sun Och , Kim Hye Ryun , Hong Min Hee , Kim Se-Heon , Choi Eun Chang , Keum Ki Chang , Lee Chang Geol 
Published: September 2022

Abstract
Purpose: Although postoperative radiotherapy (PORT) is demonstrably effective in local control of head and neck adenoid cystic carcinoma (HNACC), its application is controversial and the subset of patients who would benefit most from PORT is unknown. Herein, we analyzed the data of HNACC patients to clarify the role of PORT.
Methods: We retrospectively reviewed 187 patients with nonmetastatic HNACC who underwent surgical resection between 2005 and 2019. The study endpoints were locoregional failure-free survival (LRFFS), progression-free survival (PFS), and overall survival (OS). Subgroup analysis and recursive partitioning analysis (RPA) were performed to identify patients most likely to benefit from PORT.
Results: With a median follow-up of 84.7 months, the 5-year LRFFS, PFS, and OS were 70.0%, 52.6%, and 86.4%, respectively. Survival was significantly shorter in patients who experienced local failure than in those who did not (5-year OS: 88.1% vs. 80.5%, p=0.001). The local failure rate was significantly lower in patients who underwent PORT (16.9% vs. 31.0%, p=0.021), despite the high frequency of adverse factors. Especially, significant decreases in local failure and similar OS rates could be obtained after PORT among patients with positive margins, T2-4 stage disease, and major salivary gland tumors. The RPA model for PFS categorized patients into four groups according to three prognostic factors (T-stage, location, and sex). The RPA model for LRFFS and OS suggested three groups based on two factors (T-stage, margin for LRFFS; T-stage, grade 3 for OS).
Conclusion: PORT could prevent dismal survival, while significantly reducing local failures in high-risk HNACC patients.
CAND1 drives lipid metabolism and hepatocellular carcinoma progression by regulating FBXO11-mediated hnRNPA2B1 ubiquitination
Authors: Zhang Hao , Xia Peng , Yang Zhangshuo , Liu Jie , Zhu Yimin , Dai Caixia , Huang Zan , Zhang Zhonglin , Yuan Yufeng 
Published: September 2022

Abstract
Background
Aberrant lipid metabolism marks one of characteristic features of hepatocellular carcinoma (HCC). Here, we define the function and mechanism of CAND1 in lipid metabolism and progression of HCC in vitro and in vivo, and postulate CAND1/FBXO11/hnRNPA2B1 as a suitable therapeutic target for HCC.
Methods
We performed IHC staining, western blot analysis and prognostic analyses of CAND1 in HCC to define its prognostic value. The functions of CAND1 were evaluated through in vitro and in vivo experiments. RNA-Seq and lipidomic assays followed by serial biochemical experiments including mass spectrometry, immunoprecipitation, GST pulldown, and ubiquitination were performed to dissect the underlying mechanism.
Results
CAND1 was highly expressed in HCC tissues and cell lines and served as an independent prognostic risk factor for HCC. CAND1 promoted HCC cell proliferation, colony formation, migration, and invasion in vitro. CAND1 facilitated tumor growth and metastasis in vivo. Mechanism studies demonstrated that CAND1 promoted lipid synthesis through disrupting Skp1-Cul1-FBXO11 complex assembly. Furthermore, we identified hnRNPA2B1 as a novel FBXO11-binding partner mediating CAND1 function. FBXO11 directly bound to hnRNPA2B1 and promoted hnRNPA2B1 lysine 27 (K27)- and K48-linked ubiquitination and subsequent degradation. Interfering CAND1 by shRNA significantly reduced tumor burden in primary mouse liver cancer model and PDX model.
Conclusions
CAND1 promoted HCC and regulated lipid synthesis by upregulating hnRNPA2B1 through dissociating Skp1-Cul-FBXO11 complex, which caused hnRNPA2B1 ubiquitination and degradation. Targeting CAND1-SCFFBXO11-hnRNPA2B1 axis may be a novel strategy against HCC.
Analysis and Design of a Capacitive-Isolation-Based Information Transmission System
Authors: ZHANG Ming , LLASER Nicolas , khan Imran 
Published: September 2022

Abstract

In this paper, a CMOS information transmission system with a capacitive isolation is proposed. Thanks to the incorporation of a high-pass filter, a high voltage common-mode existing between both transmission and reception sides of the transmission system can be suppressed leaving only the useful information signal transmitted across the capacitive isolation. The integration of two passive high-pass filters has been proposed in order to adapt to different applications. A detailed circuit performance analysis has been developed together with some circuit design considerations. The proposed circuits are designed and simulated in a CMOS 0.35µm technology. The simulation results show that the proposed system with a first order of high-pass filter can cope with a common-mode of voltage up to 40V at 1MHz with its immunity as high as 240V/µs while the proposed system with a second order of high-pass filter can deal with a common-mode voltage more than 100V with an immunity up to 720V/µs. The simulation results also show that with a carrier frequency of 100MHz and the input signal of 1MHz, the signal transmission delay and the power consumption are less than 10ns and 2.8mW for the first order filter system and 12ns and 2mW for the second order filter system.
Congenital Diaphragmatic Hernia: high mortality in spite of different treatment options.
Authors: Redondo Jesus Enrique Barrios , Becerra Juan Enrique Seba , Jimenez Lina Paola Montaña , Rubiano Maria Alejandra Montoya , Camacho Maria Paula Abaunza , Ciro Maria Clara Peña 
Published: September 2022

Abstract

Introduction:
Congenital diaphragmatic hernia (CDH) is a fatal condition that affects intrauterine lung development, resulting in pulmonary hypoplasia and persistent pulmonary hypertension.
Methods:
Given the scarcity of medical information indexed in low- and middle-income countries, the objective of this study was to characterize newborns with CDH treated at the San Ignacio University Hospital (HUSI) in Bogotá, Colombia over a time period of 11 years.
Results and discussion:
Within this population, 27 patients with CDH were treated: 81% were diagnosed prenatally by ultrasound, but only 14% had records of prenatal prognostic indices. The location of the defect was predominantly on the left side and the majority were male neonates (85% and 74% respectively). The mean gestational age was 37.2 weeks and the average weight was 2805 grams.
12 patients died prior to surgical correction. In 11 patients there were associated congenital malformations and 53.4% had postoperative complications. There was a postoperative mortality of 6 patients.
Conclusions:
Taking into account that CDH is an infrequent pathology with high mortality, the possibility of improving patient assessment was found by optimizing the protocol for prenatal assessment and postnatal treatment. The importance of monitoring epidemiological data in low- and middle-income countries is highlighted.