bluuebunny/crossref_metadata_2025_split huggingface dataset:
Symptoms of anxiety/depression during the COVID-19 pandemic and associated lockdown in the community: longitudinal data from the TEMPO cohort in France
Authors: Andersen A.J. , Melchior M. , Mary-Krause M. , Herranz Bustamante J.J. , El Aarbaoui T. , Héron M. 
Published: September 2022

IntroductionThe COVID-19 pandemic and associated preventive measures have an impact on the persons’ mental health, including increasing risk of symptoms of anxiety and depression in particular. Individual experiencing mental health difficulties in the past could be especially vulnerable during lockdown, however, few studies have tested this empirically considering preexisting mental health difficulties using longitudinal data.ObjectivesThe objective of this study is to examine the longitudinal association between preexisting symptoms of anxiety/depression and symptoms of anxiety/depression during lockdown due to the COVID-19 pandemic in a community sample.MethodsSeven waves of data collection were implemented from March-May 2020. Generalized estimation equations models were used to estimate the association between preexisting symptoms of anxiety/depression and symptoms of anxiety/depression during lockdown among 662 mid-aged individuals from the French TEMPO cohort.ResultsWe found an elevated odds ratio of symptoms of anxiety/depression (OR=6.73 95% [CI=4.45–10.17]) among individuals experiencing such symptoms prior lockdown. Furthermore, the odds of symptoms of anxiety/depression during lockdown was elevated among women (OR=2.07 [95% CI=1.32–3.25]), subjects with low household income (OR=2.28 [1.29–4.01]) and persons who reported loneliness (OR=3.94 [2.47–6.28]).ConclusionsThis study demonstrates a strong relationship between preexisting symptoms of anxiety/depression and anxiety/
depression during the COVID-19 outbreak among mid-aged French adults. The findings underline the role of preexisting symptoms of anxiety/depression as a vulnerability factor of anxiety/depression during lockdown. Furthermore, the study shows that loneliness is independently associated with symptoms of anxious/depression, when controlling for prior anxiety/depression symptoms.DisclosureNo significant relationships.
Mental Health Impacts of Quarantine: Insights from the COVID-19 International Border Surveillance Study in Toronto, Canada
Authors: Regehr C. , Goel V. , De Prophetis E. , Jamil M. , Mertz D. , Rosella L. , Bulir D. , Smieja M. 
Published: September 2022

IntroductionNations thorughout the world are imposing mandatory quarantine on those entering the country. While such measures may be effective in reducing the importation of COVID-19, the mental health implications remain unclear.ObjectivesThis study sought to assess mental well-being and factors associated with changes in mental health in individuals subject to mandatory quarantine following travel.MethodsTravellers arriving at a large urban international airport completed online questionnaires on arrival and days 7 and 14 of mandated quarantine. Questionnaire items such as travel history, mental health, attitudes towards COVID-19, and protection behaviours were drawn from the World Health Organization Survey Tool for COVID-19.ResultsThere was a clinically significant decline in mental health over the course of quarantine among the 10,965 eligible participants. Poor mental health was reported by 5.1% of participants on arrival and 26% on day 7 of quarantine. Factors associated with greater decline in mental health were younger age, female gender, negative views towards quarantine measures, and engaging in fewer COVID-19 prevention behaviours.ConclusionsWhile the widespread use of quarantine may be effective in limiting the spread of COVID-19, the mental health implications are profound and have largely been ignored in public policy decision-making. Psychiatry has a role to play in contributing to the public policy debate to ensure that all aspects of health and well-being are reflected in decisions to isolate people from others.DisclosureNo significant relationships.
The moderated mediating effect of gender in the relationship between unemployment, depression, and suicide during the COVID-19 pandemic: An examination based on big data
Authors: Noh Y. , Kim H.A. , Lee S.B. 
Published: September 2022

IntroductionThe COVID-19 pandemic, and the consequent recession, have caused a decline in the job market, with the resultant job insecurity increasing the risk of depression. While this affected all genders, suicidal thoughts were observed to be more common among women than men, suggesting that the impact of unemployment on depression varies by gender, with gender differences affecting the outcome of depression.ObjectivesThis study aims to verify the moderating effect of gender on the structural relationship between unemployment, depression, and suicide during the COVID-19 pandemic by using online search trend data.MethodsThe study utilized the search trend data from Naver’s Data Lab service, by analyzing the searches of men and women under 65, between March, 2020 and September 12, 2021. The search terms were “unemployment,” “depression,” and “suicide.” The analysis examined 1121 searches using the Model 7 research model through the SPSS Process Macro to verify the moderating effect of gender on the mediating pathways for unemployment, depression, and suicide.ResultsWe observed that searches for “unemployment” significantly increased with searches for “depression” (B=1.860, p<.001) and “suicide” (B=.860, p<.001). The analysis further revealed that the correlation between the increase in searches relating to depression and unemployment was seen more in women than men. This resulted in an accompanying increase in the volume of searches for suicide (B=2.341, p<.001).ConclusionsThe job insecurity caused by the COVID-19 pandemic led to varying degrees of depression according to gender. Thus, social security measures related to unemployment, depression, and suicide interventions require a gender-specific approach.DisclosureNo significant relationships.
Does culture affect How Mental Health Is Treated And Diagnosed- What Is The Future Of It
Authors: Musolo C. , Beezhold J. 
Published: September 2022

IntroductionCulture is used to refer to the aspects of thinking, feeling, and behaviour related to nation, heritage, place of birth and ethnicity. I look at how the cultural context of mental disorders and the cultural context of mental disorders and the challenges of addressing ethnic diversity in psychiatric services because there is an over-representation of black people detained under the MHA.ObjectivesMy aim is to understand what current data shows and use this to find a way forward which identify issues with culture and independently and challenge policies, services systems and address culture in clinical practice to provide culture complement care.Methods. research on rates of detentionResultsThe MHA acts tells us POC are 4 times more likely to be detained, arrested under 136 twice as much, and are 8 times as likely to be put on CTOS. 40% of black people will more likely asses care through the police system. (mind.org, Uk) This further shows us just how unrepresented POCs are when it comes to their diagnosis, treatment, and care, especially compared to their white counterparts.ConclusionsIn conclusion regulatory bodies and clinicians have to work towards understanding and identifying the reasons for these disparities and then implementing measures to address this. Such as putting people of color in higher positions in mental health positions in mental health positions to add diversities, also teaching the staff members and other people in high positions of power how much culture really impacts mental health, culturally appropriate advocacy, and improving research done.DisclosureNo significant relationships.
Modifying Psychiatric Approaches to Respond Better to Indigenous People in Maine (North America)
Authors: Mehl-Madrona L. , Mainguy B. , Sockabasin L. 
Published: September 2022

IntroductionPsychiatry has typically underserved indigenous people and immigrants. Indigenous people have different ways of viewing mind and mental health and conventional Euro-American psychiatry has not always acknowledged that.ObjectivesWe wanted to modify conventional psychiatric approaches to better serve our indigenous population. We worked together to determine what that would be, gained feedback from indigenous patients and practitioners, and wanted to describe what we learned in an autoethnographic fashion.MethodsWe engaged each other, indigenous practitioners within the community and indigenous patients in an ongoing discussion of how psychiatry should change to be relevant to indigenous people. We monitored our own process in an autoethnographic fashion.Results1. The typical DSM (Diagnostic and Statistical Manual) or ICDA (International Classification of Diseases) categories were difficult to apply to the lives of many of these patients, given the high levels of trauma both experienced and transmitted epigenetically (inter-generational trauma). A power-threat-meaning framework appeared to be a more useful adjunct to these classifications along with trauma-informed perspectives. 2. Conventional cognitive behavior therapy was less accepted given its emphasis on rational thinking, while narrative approaches were more successful, given the widespread uses of stories and storytelling in these cultures and the emphasis on relationship as more important than rationality. 3. Trained peer counselors were very helpful. 4. Bringing culture (language, songs, ceremonies, elders, arts) into treatment was highly desirable.ConclusionsPsychiatric services to indigenous and immigrant communities should focus on empowerment through community-based, participatory methods, facilitating local problem solutions, and involving traditional elders, local government, and other stakeholders.DisclosureNo significant relationships.
Virtual Reality Cognitive Remediation for Mood disorders: RCT pilot study
Authors: Lipskaya-Velikovsky L. , Cohen D. , Livian-Carmel D. , Eger G. 
Published: September 2022

IntroductionMood disorders interrupt well-being and participation in everyday activities through, among others, a mechanism of cognitive impairments. Ample evidence was found for cognitive remediation (CR) effectiveness in various mental health conditions. However, its contribution to improvement of functional outcomes in mood disorders was little investigated. Virtual Reality (VR)-based CR has a potential to overcome limitations by enabling training on daily-life tasks in ecological environments.ObjectivesTest the effectiveness of VR-based vs standard CR for improvement of cognition, functional capacity and participation in daily-life activities in mood disorders.MethodsTwenty-two individuals (female: N=13, 59.1%; Age: M=39, SD=13.4) diagnosed with major depression or bipolar disorder were randomly assigned either to the standard or VR-based CR. The participants completed 6 half-an-hour sessions using the Functional Brain Trainer (Intendu©), a body-controlled, adaptive tool for training of inhibition, planning, working memory, shifting, self-initiation, persistence, and attention in functional tasks and environments. Standard assessments were used to evaluate cognition, functional capacity, mood symptoms and participation dimensions in pre-post design.ResultsVR-based CR contributes to improvement in memory, executive functions and construction (2<Z<2.23, p<.05), functional capacity (Z=-2.44, p<.01) and satisfaction with participation (Z= -1.9, p<.01). Standard CR contributes to executive functions (Z=2.33, p<.05), and functional capacity (Z=-2.35, p<.05).ConclusionsThis study provides initial evidence for contribution of CR to functional outcomes in mood disorders, with advantages of VR-based modality, suggesting the potential of CR to improve treatment outcomes and well-being in this population. Larger, controlled trials are needed to further expand evidence for VR-based CR effectiveness.DisclosureNo significant relationships.
Consequence of the magnocellular dysfunction on processing facial affect recognition in Schizophrenia
Authors: Marosi C. , Fodor Z. , Csukly G. 
Published: September 2022

IntroductionMagnocellular deficit in visual perception and impaired emotion recognition are core features of schizophrenia, however their relationship and the neurobiological underpinnings are still unclear.ObjectivesThe aim of our research was to investigate the oscillatory background of perception and emotion recognition in schizophrenia and to examine the relationship between these processes.MethodsThirty-nine subjects with schizophrenia and forty healthy controls subjects were enrolled in the study; the two study groups did not differ in age, gender and education. In the visual paradigm the participants viewed magnocellular biased low-spatial frequency (LSF) and parvocellular biased high-spatial frequency (HSF) Gabor-patches and in the second paradigm happy, sad and neutral faces were presented, while 128-channel EEG was recorded.ResultsSignificantly weaker theta (4-7 Hz) event related synchronisation (ERS) was observed in patients compared to controls in the LSF condition, whereas in the HSF condition there was no difference between the two groups. Event related changes in theta amplitude were also found to be significantly weaker in patients compared to healthy controls in the emotion recognition task, which difference was disappeared after correction for ERS to LSF condition. In the correlational analysis theta activity in the magnocellular biased stimuli correlated significantly with theta activity in the emotion recognition task, while theta to parvocellular biased stimuli showed no similar correlation with emotion recognition.ConclusionsIn schizophrenia, emotion recognition impairments are closely related to the dysfunction of the magnocellular system, which supports the bottom-up model of schizophrenia.DisclosureNo significant relationships.
The effects of reading literary fiction on the measurement and development of mentalization skills among schizophrenic patients
Authors: Fekete J. , Tényi T. , Pótó Z. , Varga E. , Herold R. 
Published: September 2022

IntroductionFollowing the mentalization of interpersonal relations can be improved through reading for which the influence of literary fiction can also serve as a model. Schizophrenia is characterized by extensive deficits in mentalization, and the amelioration of these impairments is a major focus in psychosocial treatment research. Reading literature can be a potential tool in improving mentalizing skills.ObjectivesWe aimed to examine and compare healthy participants with patients living with schizophrenia, focusing on measuring mentalizing skills and the impact of reading literary fiction on their mentalization skills.Methods47 persons with schizophrenia in remission and 48 healthy controls were assessed and compared with Short Story Task (SST) a new measurement of ToM. SST proved to be a sensitive tool, to individual differences. After reading the short story “The End of Something” (Hemingway) a structured interview was done with 14 questions.ResultsWe found that patients with schizophrenia performed significantly worse in their ToM scores compared to healthy controls (ANOVA test, p<0,05 ). Previous reading experiences correlated significantly with mentalizing scores not just in healthy controls (Independent Samples T-test, p<0,05) but also in patients with schizophrenia. ToM scores were twice as high among those who had prior reading experiences in the schizophrenia group ((MS= 3,91, SD=3,166, M=8,08, SD=4,542; p<0,05, t=-3,509).ConclusionsWe found that mentalization skills could be improved by regular reading. Our results could also be influenced by several other factors such as empathy skills, identification with the characters etc. Our results and conclusions are in line with the results of international research on this topic.DisclosureNo significant relationships.
The Relationships Between Strategies Of Stress Coping And Temperament-Character Traits In Subjects With Bipolar Disorder
Authors: Gundogmus I. , Tekin S. , Yasar A.B. , Uzun Ö. 
Published: September 2022

IntroductionBipolar disorder (BD) is a severe mood disorder, which is characterized by a cycling between the mania and major depression. The relationship between coping strategies and temperament-character traits in BD is unclear at this time.ObjectivesThe aim of our study was to assess the relationship between strategies of coping stress and temperament-character traits in individuals with BD.Methods168 patients diagnosed with BD in full remission were included. All participants were diagnosed by an experienced consultant psychiatrist based on DSM-5 and were assessed with Young Mania Rating Scale (YMRS) for confirmation to remission. Sociodemographic datas of all participants was obtained and Temperament Evaluation of Memphis, Pisa, Paris and San Diego–Autoquestionnaire (TEMPS-A) and Coping with Stress Scale (CSS) were applied.Results75 patients (44.6%) were female and the mean age of the sample was 32.64±10.74 years, the mean duration of illness was 8.23±5.52 years and was found that the mean score of YMRS 5.35±4.19. It was presented Table 1 whether there was a statistically significant correlation between TEMPS-A and CSS subscales.ConclusionsAs coping strategies may be related to temperament-character traits and that could be important for psychological interventions in patients with BD.
Depressive
Hypertimic
Cyclothymic
IrritableAnxiousAvoidance-,067-,159,098-,150-,083,485,095,305,115,387Problem-focused coping strategies-,268-,153,366-,246-,134,004,109,000-,009,161Social support-,191-,495-,060-,646-,416,044,000,535,000,000Total-,256-,399,149-,370-,324,007,000,118,000,001DisclosureNo significant relationships.
Cariprazine’s efficacy in treating affective symptoms – pooled data from schizophrenia and bipolar depression trials
Authors: Mcintyre R. , Dombi Z. , Barabássy Á. , Németh G. 
Published: September 2022

IntroductionAffective symptoms are a common feature of schizophrenia and define bipolar disorder. Alterations in dopamine neurotransmission and activity at D3-D2 receptors is associated with depressive symptoms providing the rationale for targeting D3-D2 receptors with partial agonists.ObjectivesThe aim of the analysis herein is to examine and compare the efficacy of cariprazine in treating affective symptoms in both schizophrenia and bipolar depression.MethodsData from 3 schizophrenia [NCT00694707, NCT01104766, NCT01104779] and 3 bipolar I depression studies [NCT013896447, NCT02670538, NCT0267055] were pooled for the analyses. To investigate efficacy across individual affective symptoms, the Marder anxiety/depression and negative symptom items of the Positive and Negative Syndrome Scale (PANSS) and single items of the Montgomery-Asberg Depression Rating Scale (MADRS) were analysed. Improvement across affective symptoms was examined primarily evaluating least square mean differences (LSMDs) in comparison to placebo in mean change from baseline.ResultsThe pooled ITT population was comprised of persons with schizophrenia (placebo=442, cariprazine=1024) and bipolar disorder (placebo=460, cariprazine=923). Cariprazine resulted in a significantly greater reduction when compared to placebo in three out of the four Marder anxiety/depression items; anxiety (p<0.01), tension (p<0.001) and depression (p<0.05). Similarly, cariprazine was significantly better than placebo in 9 out of the 10 MADRS individual items; apparent sadness (p<0.001), reported sadness (p<0.001), reduced sleep (p<0.05), reduced appetite (p<0.001), concentration difficulties (p<0.001), lassitude (p<0.001), inability to feel (p<0.001), pessimistic thoughts (p<0.01) and suicidal thoughts (p<0.05).ConclusionsThe results herein indicate that cariprazine treatment is significantly effective at treating affective symptoms in persons with both schizophrenia and bipolar I depression.DisclosureI am an employee of Gedeon Richter Plc.
Predictors of functional impairment in patients with bipolar disorder
Authors: Kartal C. , Aydın E.F. 
Published: September 2022

IntroductionPsychosocial functioning is an an important issue in the follow-up processes of patients with bipolar disorder. Potential predictors of functional impairment in bipolar disorder may give a chance to improve functioning in this group of patients.ObjectivesWe aimed to assess the differences between patients with bipolar disorder and healthy controls due to childhood traumas, attachment styles, dysfunctional attitudes, affective temperaments and to assess which of these factors may significantly predict the overall functional impairment in patients with bipolar disorder.Methods63 remitted patients with bipolar disorder and 61 healthy controls were enrolled in the study. Asessment was conducted using a sociodemoghraphic and clinical questionnaire, Hamilton Depression Rating Scale 17-item version (HAM-D-17) and the Young Mania Rating Scale (YMRS), Childhood Trauma Questionnaire(CTQ-28), Relationship Scales Questionnaire (RSQ), Dysfunctional Attitudes Scale (DAS), Temperament Evaluation of Memphis, Pisa, Paris and San Diego (TEMPS-A) and Functioning Assesment Short Test (FAST).ResultsIn the patient group scores of childhood traumas, dysfunctional attitudes, cyclothymic, depressive and anxious temperaments, all domains of functional impairment scores except financial issues, and overall functional impairment scores were significantly higher than the control group. Besides this, secure attachment scores were significantly higher in the control group. In the regression analysis anxious temperament and subclinical depressive symptoms significantly positively predicted functional impairment and hyperthymic temperament significantly negatively predicted functional impairment in patients with bipolar disorder.ConclusionsIn the assessment of functioning of patients with bipolar disorder subclinical depressive symptoms, hyperthymic and anxious affective temperament styles might be taken into consideration.DisclosureNo significant relationships.
Has Clinical Translation of Scientific Research been a Failure?
Authors: Binder E. 
Published: September 2022

While current psychiatric treatments, especially pharmacological ones, are mainly based on initially serendipous findings, recent developments in many research areas promise unprecendented advances in translation to clinical application. The advent of large scale multiomics with single cell resolution, patient-derived induced pluripotent stem cells that can be differentiated to brain cells and even form cerebral organoids as well as the possilibility to generate humanized animal models using CRISPR-technologies have been exciting developments on the molecular and cellular side. These advances are paralleled by new technologies to increase resolution in brain imaging and electrophysiological measures as well as brain stimulation techniques. In addition, we have now access to multilevel data from very large cohorts, increasingly with longitudinal measures and using data collection with digital devices and wearables. Artificial intelligence methods open new possibilities to analyze these large scale, multilevel datasets in unbiased ways. This side of the debate will highlight the translational potential of these advances in research possiblities, giving examples from the areas of novel pharmacological treatments and personalized medicine among others. Furthermore, it will highlight how a better understanding of risk factors, genetic, social and environmental, can lead to improvements in prevention programs.DisclosureNo significant relationships.