bluuebunny/crossref_metadata_2025_split huggingface dataset:
Avian predators taste reject mimetic prey in relation to their signal reliability
Authors: He R. , Pagani-Núñez E. , Goodale E. , Barnett C. R. A. 
Published: February 2022

AbstractAposematic organisms defend themselves through various means to increase their unprofitability to predators which they advertise with conspicuous warning signals. Predators learn to avoid aposematic prey through associative learning that leads to lower predation. However, when these visual signals become unreliable (e.g., through automimicry or Batesian mimicry), predators may switch from using visual signals to taste sampling prey to choose among them. In this experiment, we tested this possibility in a field experiment where we released a total of 4800 mealworm prey in two clusters consisting of either: (i) undefended prey (injected with water) and (ii) model-mimics (injected with either quinine sulphate [models] or water [mimics]). Prey were deployed at 12 sites, with the mimic frequency of the model-mimics ranging between 0 and 1 (at 0.2 intervals). We found that taste rejection peaked at moderate mimic frequencies (0.4 and 0.6), supporting the idea that taste sampling and rejection of prey is related to signal reliability and predator uncertainty. This is the first time that taste-rejection has been shown to be related to the reliability of prey signals in a mimetic prey system.
Tomographic reconstruction from planar thermal imaging using convolutional neural network
Authors: Ledwon Daniel , Sage Agata , Juszczyk Jan , Rudzki Marcin , Badura Pawel 
Published: February 2022

AbstractIn this study, we investigate perspectives for thermal tomography based on planar infrared thermal images. Volumetric reconstruction of temperature distribution inside an object is hardly applicable in a way similar to ionizing-radiation-based modalities due to its non-penetrating character. Here, we aim at employing the autoencoder deep neural network to collect knowledge on the single-source heat transfer model. For that purpose, we prepare a series of synthetic 3D models of a cylindrical phantom with assumed thermal properties with various heat source locations, captured at different times. A set of planar thermal images taken around the model is subjected to initial backprojection reconstruction, then passed to the deep model. This paper reports the training and testing results in terms of five metrics assessing spatial similarity between volumetric models, signal-to-noise ratio, or heat source location accuracy. We also evaluate the assumptions of the synthetic model with an experiment involving thermal imaging of a real object (pork) and a single heat source. For validation, we investigate objects with multiple heat sources of a random location and temperature. Our results show the capability of a deep model to reconstruct the temperature distribution inside the object.
Hybrid magnetron sputtering of ceramic superlattices for application in a next generation of combustion engines
Authors: de Castilho Bruno César Noronha Marques , Rodrigues Alisson Mendes , Avila Pedro Renato Tavares , Apolinario Raíra Chefer , Nossa Tamires de Souza , Walczak Magdalena , Fernandes Jucielle Veras , Menezes Romualdo Rodrigues , de Araújo Neves Gelmires , Pinto Haroldo Cavalcanti 
Published: February 2022

AbstractA hybrid magnetron sputtering process (dcMS/HiPIMS) was developed to manufacture nanostructured CrN/Cr1-xAlxN multilayers, motivated by improving the low-emission efficiency when applied on gas-nitrided diesel piston rings of a next-generation of combustion engines. In order to improve the mechanical, tribological, and corrosion behavior of the multilayers, the hybrid dcMS/HiPIMS process was designed by selecting the optimal sputtering procedure applied to AISI 440 base steel. The effect of substrate bias and carousel rotational speed on the phase composition, crystallographic texture, residual stresses, surface roughness, coating periodicity and densification, instrumented hardness, elastic modulus, as well as wear and corrosion resistance was determined. The results have demonstrated that hybrid magnetron sputtering produces multilayers with a superlattice structure, which outperforms commercial PVD coatings of CrN for diesel piston rings manufactured by cathodic arc evaporation. Also, multilayer periodicities in the range of 5 to 10 nm yield the best tribological performance under bench tests for the piston ring/cylinder liner system.
Virtual monoenergetic micro-CT imaging in mice with artificial intelligence
Authors: van der Heyden Brent , Roden Stijn , Dok Rüveyda , Nuyts Sandra , Sterpin Edmond 
Published: February 2022

AbstractMicro cone-beam computed tomography (µCBCT) imaging is of utmost importance for carrying out extensive preclinical research in rodents. The imaging of animals is an essential step prior to preclinical precision irradiation, but also in the longitudinal assessment of treatment outcomes. However, imaging artifacts such as beam hardening will occur due to the low energetic nature of the X-ray imaging beam (i.e., 60 kVp). Beam hardening artifacts are especially difficult to resolve in a ‘pancake’ imaging geometry with stationary source and detector, where the animal is rotated around its sagittal axis, and the X-ray imaging beam crosses a wide range of thicknesses. In this study, a seven-layer U-Net based network architecture (vMonoCT) is adopted to predict virtual monoenergetic X-ray projections from polyenergetic X-ray projections. A Monte Carlo simulation model is developed to compose a training dataset of 1890 projection pairs. Here, a series of digital anthropomorphic mouse phantoms was derived from the reference DigiMouse phantom as simulation geometry. vMonoCT was trained on 1512 projection pairs (= 80%) and tested on 378 projection pairs (= 20%). The percentage error calculated for the test dataset was 1.7 ± 0.4%. Additionally, the vMonoCT model was evaluated on a retrospective projection dataset of five mice and one frozen cadaver. It was found that beam hardening artifacts were minimized after image reconstruction of the vMonoCT-corrected projections, and that anatomically incorrect gradient errors were corrected in the cranium up to 15%. Our results disclose the potential of Artificial Intelligence to enhance the µCBCT image quality in biomedical applications. vMonoCT is expected to contribute to the reproducibility of quantitative preclinical applications such as precision irradiations in X-ray cabinets, and to the evaluation of longitudinal imaging data in extensive preclinical studies.
Super high-quality SEM/FIB imaging of dentine structures without collagen fiber loss through a metal staining process
Authors: Xu Shiyou , Stranick Michael , Hines Deon , Du Ke , Pan Long 
Published: February 2022

AbstractScanning Electron Microscope/Focused Ion Beam (SEM/FIB) system has become valuable and popular tool for the analysis of biological materials such as dentine structures. According to physiological and anatomical studies, dentine structures are a complicated system containing collagen fibers, nanocrystalline hydroxyapatite, and numerous networks of tubular pores. During a routine FIB milling process, collagen fibers and other organic structures are vaporized, which increases the number of pores on the milled surface of the dentine. This causes the final cross-section to be more porous than the pristine sample. Unfortunately, little attention has been paid to the collagen fiber loss and how to preserve them during a FIB milling process. In this work, we present a novel and simple approach to preserve the organic portions of the dentine structure through metal staining. By using this method, the porosity of the dentine structure after the FIB milling process is significantly reduced similar to the pristine sample. This indicates that the organic portion of the dentine structure is well protected by the metal staining. This approach enables the SEM/FIB system to generate super-high quality SEM images with less ion beam damage; and the SEM images can better reflect the original condition of the dentine structure. Further, serial energy-dispersive X-ray spectroscopy (EDS) mapping of the stained dentine structure is achieved without an additional metal coating; and three-dimensional (3-D) elemental mapping of an occluded dentine is achieved with a significantly reduced data acquisition time.
Relationship between oxidative stress and lifespan in Daphnia pulex
Authors: Ukhueduan Benedicth , Schumpert Charles , Kim Eunsuk , Dudycha Jeffry L. , Patel Rekha C. 
Published: February 2022

AbstractMacromolecular damage leading to cell, tissue and ultimately organ dysfunction is a major contributor to aging. Intracellular reactive oxygen species (ROS) resulting from normal metabolism cause most damage to macromolecules and the mitochondria play a central role in this process as they are the principle source of ROS. The relationship between naturally occurring variations in the mitochondrial (MT) genomes leading to correspondingly less or more ROS and macromolecular damage that changes the rate of aging associated organismal decline remains relatively unexplored. MT complex I, a component of the electron transport chain (ETC), is a key source of ROS and the NADH dehydrogenase subunit 5 (ND5) is a highly conserved core protein of the subunits that constitute the backbone of complex I. Using Daphnia as a model organism, we explored if the naturally occurring sequence variations in ND5 correlate with a short or long lifespan. Our results indicate that the short-lived clones have ND5 variants that correlate with reduced complex I activity, increased oxidative damage, and heightened expression of ROS scavenger enzymes. Daphnia offers a unique opportunity to investigate the association between inherited variations in components of complex I and ROS generation which affects the rate of aging and lifespan.
Response of Iranian lizards to future climate change by poleward expansion, southern contraction, and elevation shifts
Authors: Vaissi Somaye 
Published: February 2022

AbstractThis study explores the relationships between recent Iranian lizard species distributions and the observed climate, as well as potential future distributions of species. For this purpose, an ensemble of seven algorithms was used to forecast the distributions of 30 species for the recent and future (2070) based on the averages of 14 global climate models under optimistic (RCP2.6) and pessimistic (RCP8.5) scenarios. Annual precipitation (n = 16) and annual mean temperature (n = 7) were identified as the most important variables in determining the distribution of 76.66% (23 out of 30) of the species. The consensus model predicts that the ranges of 83.33% of species (n = 25) have the potential to expand poleward at higher latitudes while preserving the majority of their recent distributions (except for four species). Furthermore, the ranges of the remaining species (n = 5) will be preserved at higher latitudes. However, they (n = 22) may contract slightly (n = 13) or excessively (n = 9) in the south of their distribution range at lower latitudes. These results indicate that species (N = 19) situated in mountainous areas such as the Zagros, Alborz, and Kopet Dagh may move or maintain their range at higher elevations as a result of future climate change. Finally, this study suggests that 30% of species (n = 9) may be threatened by future climate change and that they should be prioritized in conservation efforts.
Transmission electron microscopy study of suspected primary ciliary dyskinesia patients
Authors: Rezaei Mitra , Soheili Amirali , Ziai Seyed Ali , Fakharian Atefeh , Toreyhi Hossein , Pourabdollah Mihan , Ghorbani Jahangir , Karimi-Galougahi Mahboobeh , Mahdaviani Seyed Alireza , Hasanzad Maryam , Eslaminejad Alireza , Ghaffaripour Hossein Ali , Mahmoudian Saied , Rodafshani Zahra , Mirenayat Maryam Sadat , Varahram Mohammad , Marjani Majid , Tabarsi Payam , Mansouri Davood , Jamaati Hamid Reza , Velayati Ali Akbar 
Published: February 2022

AbstractPrimary ciliary dyskinesia (PCD) is a rare autosomal recessive condition often presenting with chronic respiratory infections in early life. Transmission electron microscopy (TEM) is used to detect ciliary ultrastructural defects. In this study, we aimed to assess ciliary ultrastructural defects using quantitative methods on TEM to identify its diagnostic role in confirming PCD. Nasal samples of 67 patients, including 37 females and 30 males (20.3 ± 10.7 years old), with suspected PCD symptoms were examined by TEM. The most common presentations were bronchiectasis: 26 (38.8%), chronic sinusitis: 23 (34.3%), and recurrent lower respiratory infections: 21 (31.3%). Secondary ciliary dyskinesia, including compound cilia (41.4%) and extra-tubules (44.3%), were the most prevalent TEM finding. Twelve patients (17.9%) had hallmark diagnostic criteria for PCD (class 1) consisting of 11 (16.4%) outer and inner dynein arm (ODA and IDA) defects and only one concurrent IDA defect and microtubular disorganization. Also, 11 patients (16.4%) had probable criteria for PCD (class 2), 26 (38.8%) had other defects, and 18 (26.9%) had normal ciliary ultrastructure. Among our suspected PCD patients, the most common ultrastructural ciliary defects were extra-tubules and compound cilia. However, the most prevalent hallmark diagnostic defect confirming PCD was simultaneous defects of IDA and ODA.
Selection for specific behavioural traits does not influence preference of chasing motion and visual strategy in dogs
Authors: Abdai Judit , Miklósi Ádám 
Published: February 2022

AbstractPerception of inanimate objects as animate based on motion cues alone seems to be present in phylogenetically distant species, from birth (humans and chicks). However, we do not know whether the species’ social and ecological environment has an influence on this phenomenon. Dogs serve as a unique species to investigate whether selection for specific behavioural traits influences animacy perception. We tested purebred companion dogs, and assigned them into two groups based on the type of work they were originally selected for: (1) Chasers, tracking and chasing prey; (2) Retrievers, mark and remember downed game. We displayed isosceles triangles presenting a chasing pattern vs moving independently, in parallel on a screen. We hypothesised that Chasers prefer to look at chasing and Retrievers eventually focus their visual attention on the independent motion. Overall, we did not find a significant difference between groups regarding the looking duration of dogs or the frequency of their gaze alternation between the chasing and independent motions. Thus it seems that selection for specific traits does not influence the perception of animate entities within the species.
Elucidating the effect of body mass index, height, and parity on uncomplicated cystitis: a nationwide population-based cohort study
Authors: Jansåker Filip , Li Xinjun , Sundquist Kristina 
Published: February 2022

AbstractIn this nationwide cohort of one million fertile women, BMI, height, and parity only had minor but statistically significant effects on the risk of uncomplicated cystitis. The results indicate that underweight women and certain sociodemographic groups might have higher risks, which could have underlying explanations that need further studying.
New white light-emitting halochromic stilbenes with remarkable quantum yields and aggregation-induced emission
Authors: Panahi Farhad , Mahmoodi Ali , Ghodrati Sajjad , Abdi Ali Ashtiani , Eshghi Fazlolah 
Published: February 2022

AbstractHighly efficient single-component white light emitters (SWLEs), are attractive candidates for the simple and cost-effective fabrication of high-performance lighting devices. This study introduced a donor–π–acceptor and a donor–π–donor stilbene-based chromophores, representing pH-responsive fluorescence. The emitters showed yellow and green fluorescence in their neutral form. At the same time, protonation of the chromophores caused blue fluorescence color with a strong hypsochromic shift. The white light emission (WLE) for these chromophores was observed at approximately pH  3 due to the simultaneous presence of the neutral and protonated forms of the chromophores, covering almost all the emission spectra in the visible region (400–700 nm). These chromophores presented exceptional white light quantum yields (Φ) between 31 and 54%, which was desirable for producing white light-emitting devices. Density functional theory (DFT) and time-dependent (TD)-DFT were applied to study the structural and electronic properties of the chromophores.
Microbial contribution to post-fire tundra ecosystem recovery over the 21st century
Authors: Bouskill Nicholas J. , Mekonnen Zelalem , Zhu Qing , Grant Robert , Riley William J. 
Published: February 2022

AbstractTundra ecosystems have experienced an increased frequency of fire, and this trend is predicted to continue throughout the 21st Century. Post-fire recovery is underpinned by complex interactions between microbial functional groups that drive nutrient cycling. Here we use a mechanistic model to demonstrate an acceleration of the nitrogen cycle post-fire driven by changes in niche space and microbial competitive dynamics. We show that over the first 5-years post-fire, fast-growing bacterial heterotrophs colonize regions of the soil previously occupied by slower-growing saprotrophic fungi. The bacterial heterotrophs mineralize organic matter, releasing nutrients into the soil. This pathway outweighs new sources of nitrogen and facilitates the recovery of plant productivity. We broadly show here that while consideration of distinct microbial metabolisms related to carbon and nutrient cycling remains rare in terrestrial ecosystem models, they are important when considering the rate of ecosystem recovery post-disturbance and the feedback to soil nutrient cycles on centennial timescales.
Update Breast Cancer 2021 Part 5 – Advanced Breast Cancer
Authors: Lüftner Diana , Schütz Florian , Stickeler Elmar , Fasching Peter A. , Janni Wolfgang , Kolberg-Liedtke Cornelia , Kolberg Hans-Christian , Thomssen Christoph , Müller Volkmar , Fehm Tanja N. , Belleville Erik , Bader Simon , Untch Michael , Welslau Manfred , Thill Marc , Tesch Hans , Ditsch Nina , Lux Michael P. , Wöckel Achim , Aktas Bahriye , Schneeweiss Andreas , Würstlein Rachel , Hartkopf Andreas D. 
Published: February 2022

AbstractDespite the COVID 19 pandemic and mostly virtual congresses, innovation in the treatment of breast cancer patients continues at an unabated pace. This review summarises the current developments. Initial overall survival data for CDK4/6 inhibitor treatment in combination with an aromatase inhibitor as the first advanced line of therapy in treatment-naive postmenopausal patients have been published. Similarly, a trial comparing trastuzumab-deruxtecan versus trastuzumab-emtansine revealed a clear benefit regarding progression-free survival. Understanding of biomarkers making checkpoint inhibitor therapy particularly effective is increasing, and new compounds such as oral selective estrogen receptor destabilisers (SERDs) are entering clinical development and completing the first phase III trials.
Bilateral Radioscopically Guided Erector Spinae Plane Block for Postoperative Analgesia in Spine Surgery: A Randomized Clinical Trial
Authors: Beltrame Sofia Angeles , Fasano Francisco , Jalón Pablo 
Published: February 2022

Abstract
Background We compare two perioperative pain management procedures(a radioscopicallyguided erector spinae plane [ESP] block versus the standard wound infiltration technique with local anesthetics) in patients undergoing lumbosacral spine surgery.
Methods A randomized, double-blind clinical trial was performed, in which adults at our hospital undergoing lumbosacral surgery without fixation were randomly assigned to receive either the standard wound infiltration technique, employing long-term anesthetics, or a radioscopicallyguided ESP block. Postoperative pain severity, morphine consumption, number of patients immobilized due to wound pain, length of hospitalization, and complications were recorded.
Results Over the first 7 postoperative hours, pain relief was superior in the ESP block group among patients who underwent diskectomies or one-level decompression (p< 0.0001). Using an ESP block also was statistically superior at decreasing all postoperative variables recorded in patients scheduled for multilevel decompression: visual analog scale (VAS) pain severity over the first 7 hours after the procedure (p = 0.0004); number of patients with wound pain 1 (p = 0.049), 7 (p< 0.0001), and 24 hours (p = 0.007) after surgery; length of hospitalization (p = 0.0007), number of patients immobilized for wound pain (p = 0.0004) and rescue morphine consumption (p< 0.0001).
Conclusion The ESP block is a safe procedure that seems to outperform the infiltration wound technique for postoperative pain management in patients undergoing open spinal surgery. Future studies are needed to verify its effectiveness for arthrodesis/fixation and minimallyinvasive procedures, and for chronic spine pain relief.
ShuntScope-Guided Versus Free-Hand Technique for Ventricular Catheter Placement: A Retrospective Comparative Study of Intraventricular Catheter Tip Position and Complication Rate
Authors: Issa Mohammed , Nofal Mohammed , Miotk Nikolai , Seitz Angelika , Unterberg Andreas , El Damaty Ahmed 
Published: February 2022

Abstract
Background The position of the ventricular catheter (VC) is essential for a proper function of cerebrospinal fluid diversion system. A ShuntScope-guided (SG) method might be helpful in reducing complications. The purpose of this study is to compare the accuracy of catheter placement and the complication and revision rates between SG and free-hand (FH) techniques.
Methods This is a retrospective study based on a prospectively acquired database of patients who underwent VC placement between September 2018 and July 2021. Accuracy of catheter placement was graded on postoperative imaging using the 3-point Hayhurst grading system. Complication and revision rates were documented and compared between both groups with an average follow-up period of 20.84 months.
Results Fifty-seven patients were included. The SG technique was used in 29 patients (mean age was 6.3 years, 1.4–27.7 years, 48.1% females), and the FH technique was used in 28 patients (mean age was 26.7 years, 0.83–79.5 years, 67.9% female). The success rate for the optimal placement of the VC with grade I on the Hayhurst scale was significantly higher in the SG group (93.1%) than in the FH group (60.7%), p = 0.012. The revision rate was higher in the FH group with 35.7% versus 20.7% in the SG group, p = 0.211.
Conclusion VC placement using the SG technique is a safe and effective procedure, which enabled a significantly higher success rate and lower revision and complication rate. Accordingly, we recommend using the SG technique especially in patients with difficult anatomy.