bluuebunny/crossref_metadata_2025_split huggingface dataset:
Compelling Evidence for the ε‐Phase InSe Crystal by Oblique Incident Second Harmonic Generation
Authors: Sun Zeyuan , Zhang Yu , Qian Jimin , Qiao Ruixi , Li Xian , Wang Zerui , Zheng Changlin , Liu Kaihui , Cao Ting , Liu Wei‐Tao , Wu Shiwei 
Published: July 2022

AbstractIndium selenide (InSe), a layered semiconductor with direct band gap and high carrier mobility, holds promising applications in bendable electronics and ultrafast optoelectronics. Yet its crystal structure exhibits polytypism with four different stacking orders (γ‐, ε‐, β‐ and δ‐phases), arising from the weak van der Waals interlayer coupling. These phases are nearly‐degenerate in energy but are predicted to have contrasting electronic structures for versatile applications. It remains highly challenging to distinguish between these polytypes due to the lack of noninvasive tools that are sensitive enough to the interlayer structural variations. Here, the unambiguous discrimination of different InSe polytypes using symmetry‐sensitive oblique incident optical second harmonic generation (SHG) is demonstrated. Surprisingly, the ε‐phase is found to be dominant, although the samples from two popular commercial vendors (2D Semiconductors and Six Carbon Technology) are claimed to be the γ‐phase. These results would help promoting the precise application of InSe crystal for piezoelectric transducer and strain sensing, as well as showing the oblique incident SHG to be a powerful structural analytical tool for van der Waals layered materials.
3D Printed Skin‐Interfaced UV‐Visible Hybrid Photodetectors
Authors: Ouyang Xia , Su Ruitao , Ng Daniel Wai Hou , Han Guebum , Pearson David R. , McAlpine Michael C. 
Published: July 2022

AbstractPhotodetectors that are intimately interfaced with human skin and measure real‐time optical irradiance are appealing in the medical profiling of photosensitive diseases. Developing compliant devices for this purpose requires the fabrication of photodetectors with ultraviolet (UV)‐enhanced broadband photoresponse and high mechanical flexibility, to ensure precise irradiance measurements across the spectral band critical to dermatological health when directly applied onto curved skin surfaces. Here, a fully 3D printed flexible UV‐visible photodetector array is reported that incorporates a hybrid organic‐inorganic material system and is integrated with a custom‐built portable console to continuously monitor broadband irradiance in‐situ. The active materials are formulated by doping polymeric photoactive materials with zinc oxide nanoparticles in order to improve the UV photoresponse and trigger a photomultiplication (PM) effect. The ability of a stand‐alone skin‐interfaced light intensity monitoring system to detect natural irradiance within the wavelength range of 310–650 nm for nearly 24 h is demonstrated.
Frailty and surgical outcomes in gastrointestinal cancer: Integration of geriatric assessment and prehabilitation into surgical practice for vulnerable patients
Authors: Mima Kosuke , Nakagawa Shigeki , Miyata Tatsunori , Yamashita Yo‐ichi , Baba Hideo 
Published: July 2022

AbstractAs life expectancy increases, the older population continues to grow rapidly, resulting in increased requirement for surgery for older patients with gastrointestinal cancer. Older individuals represent a heterogeneous group in terms of physiological reserves, co‐morbidity, cognitive impairment, and disability. Owing to the lack of treatment guidelines for vulnerable patients with gastrointestinal cancer, these patients are more likely to be at risk of undertreatment or overtreatment. Hence, the identification of frail patients with gastrointestinal cancer would improve cancer treatment outcomes. Although there is no standardized geriatric assessment tool, a growing body of research has shown associations of frailty with adverse postoperative outcomes and poor prognosis after resection of gastrointestinal tract and hepatobiliary‐pancreatic cancers. Emerging evidence suggests that prehabilitation, which includes exercise and nutritional support, can improve preoperative functional capacity, postoperative recovery, and surgical outcomes, particularly in frail patients with gastrointestinal cancer. We reviewed major geriatric assessment tools for identification of frail patients and summarized clinical studies on frailty and surgical outcomes, as well as prehabilitation or rehabilitation in gastrointestinal tract and hepatobiliary‐pancreatic cancers. The integration of preoperative geriatric assessment and prehabilitation of frail patients in clinical practice may improve surgical outcomes. In addition, improving preoperative vulnerability and preventing functional decline after surgery is important in providing favorable long‐term survival in patients with gastrointestinal cancer. Further clinical trials are needed to examine the effects of minimally invasive surgery, and chemotherapy in frail patients with gastrointestinal cancer.
The relationship between total energy expenditure and physical activity level in women living in an impoverished Brazilian urban area
Authors: Macena Mateus L. , Hoffman Daniel J. , Clemente Ana Paula , Ferriolli Eduardo , Pfrimer Karina , Florêncio Telma Maria T. , Bueno Nassib B. 
Published: July 2022

AbstractObjectiveThis study aimed to describe how strong is the relationship between TEE and PAL in women living in an impoverished Brazilian urban area.MethodsAnthropometric, hormonal (insulin, TSH, FT4, and FT3), body composition (deuterium), TEE (doubly labeled water) and PAL (metabolic equivalent task [MET]—7‐day triaxial accelerometer, ActivPAL®) data were collected from 55 women (mean age: 31y, mean BMI: 27.4 kg/m2). Adjusted‐TEE models were calculated incorporating the residuals of anthropometric, hormonal, and body composition variables in the TEE, to assess the relation between MET and adjusted‐TEE, through three different analyzes: linear regression, nonlinear regression and change‐point regression.ResultsMost participants (89.1%, n = 49) were classified as low‐active. There was no association between crude TEE and MET.h/d (R2 = 0.05; p = 0.09). There was a positive, although weak, linear relationship between adjusted‐TEE and MET.h/d (β = 2705.26 kcal; 95% CI: 436.25; 4974.27; adj‐R2 = 0.08). A change point of this relationship was identified in the MET.h/d value of 1.53 (SD = 0.02; adj‐R2= 0.13). The association between adjusted‐TEE and MET.h/d before the change point (β = 5101.46 kcal; 95%CI: 978.84; 9224.08; adj‐R2 = 0.11) was stronger than the association in the full linear model, nevertheless, it was still weak. This association stop existing when it is assessed in individuals after the change point (β = −6609.92 kcal; 95%CI: −16773.24; 3553.40; adj‐R2 = 0.08).ConclusionsThese results suggest that the relationship between TEE and PAL is weak and it is not completely linear in women living in an impoverished Brazilian urban area.
Synthetic Applications of Ambiphilic C‐acylimines in Organic Synthesis
Authors: Pareek Abhishek , Singh Garima , Yaragorla Srinivasarao 
Published: July 2022

AbstractC‐acylimines are generally obtained through condensation/dehydration of simple and readily available glyoxals and amines. The structure resembles naturally occurring biological substances due to the presence of the imino group (−N=C−). Chemically, C‐acylimines exhibit ambiphilic reactivity, and hence, their synthetic chemistry becomes more attractive and viable for the synthesis of various aza‐cyclic/heterocyclic compounds, including their asymmetric counterpart. Therefore, many synthetic methodologies were developed from these readily preparable C‐acylimines. Surprisingly, there is no account/review available on this specific topic. Hence we present here an account of all the synthetic endeavours developed from C‐acylimines to synthesize small molecules and complex systems using various strategies.
The impacts of health insurance and resource on the burden of Alzheimer's disease and related dementias in the world population
Authors: Wang Jin‐Tao , Xu Gang , Ren Ru‐Jing , Wang Ying , Tang Ran , Huang Qiang , Li Jian‐Ping , Al‐Nusaif Murad , Le Wei‐Dong , Wang Gang 
Published: July 2022

AbstractIntroductionThe increasing prevalence of Alzheimer's disease and related dementias (ADRD) presents both a burden and an opportunity for intervention. This study aims to estimate the impacts of health insurance and resources on the burden attributed to ADRD.MethodData were mainly collected from global databases for ADRD. Analysis of variance, Pearson correlation, random‐effects, and fixed‐effects model analyses were used in this study.ResultsAlthough the current medical expenditures were increasing and out of pocket (OOP) expenditures were declining generally in various countries, the collected global data showed an increased burden of ADRD on patients both physically and economically. Furthermore, health resources were negatively associated with disability‐adjusted life years (DALY), death, and years of life lost (YLL), but were otherwise positively associated with years of life lived with disability (YLD).DiscussionEffective measures should be considered to cope with the rising burden. Meanwhile, there is an urgent call for constructive and sustainable rational plans and global collaboration.Highlights
We explored how health insurance and resources affect Alzheimer's disease and related dementias (ADRD)‐related burden.
Health insurance and resources were imbalanced among four income level groups.
Health insurance and resources may decrease the total ADRD burden primarily from a reduction in death‐related burden.
Health insurance and resources may increase disability‐related burden.
Pentadecanedioic acid production from 15‐hydroxypentadecanoic acid using an engineered biocatalyst with a co‐factor regeneration system
Authors: Shin Kyung‐Chul , Kang Su‐Hwan , Lee Tae‐Eui , Kim Tae‐Hun , Oh Deok‐Kun 
Published: July 2022

Abstractα,ω‐Dicarboxylic acids are valuable precursors in various chemical industries and have recently been produced using biotechnological methods to overcome the limitations of chemical synthesis. Nonanedioic acid, decanedioic acid, undecanedioic acid, and dodecanedioic acid have been produced at high concentrations from ω‐hydroxycarboxylic acids using engineered biocatalysts. However, no study has been attempted on the efficient production of pentadecanedioic acid. Here, the production of pentadecanedioic acid from 15‐hydroxypentadecanoic acid was carried out with alcohol dehydrogenases (ADHs), aldehyde dehydrogenases (ALDHs), and NAD(P)H oxidases, including NAD(P)H flavin oxidoreductase (NFO), that used a co‐factor regeneration system, derived from several species and expressed in Escherichia coli. Among the enzymes, Kangiella koreensis ADH (KkADH), Geobacillus kaustophilus ALDH (GkALDH), and Deinococcus radiodurans NFO (DrNFO) were selected because they had the highest activity. E. coli expressing pRSF‐DrNFO and pACYC‐KkADH/GkALDH as the best distribution of three genes in two plasmids was used as a biocatalyst to produce pentadecanedioic acid. The optimal conditions for producing pentadecanedioic acid from 15‐hydroxypentadecanoic acid by the biocatalyst were pH 8.0, 35°C, 5% (v/v) methanol, 40 g L−1 cells, and 60 mM 15‐hydroxypentadecanoic acid with agitation at 250 rpm. Under these optimized conditions, 57.4 mM pentadecanedioic acid was produced after 3 h, with a molar yield of 95.6% and a productivity of 19.1 mM h−1. The molar yield and concentration of pentadecanedioic acid showed the highest values among the reported biotechnological production of pentadecanedioic acid.
Both Disease Activity and HLA–B27 Status Are Associated With Gut Microbiome Dysbiosis in Spondyloarthritis Patients
Authors: Berland Magali , Meslier Victoria , Berreira Ibraim Samar , Le Chatelier Emmanuelle , Pons Nicolas , Maziers Nicolas , Thirion Florence , Gauthier Franck , Plaza Oñate Florian , Furet Jean‐Pierre , Leboime Ariane , Said‐Nahal Roula , Levenez Florence , Galleron Nathalie , Quinquis Benoît , Langella Philippe , Ehrlich Stanislav Dusko , Breban Maxime 
Published: July 2022

ObjectiveGut microbiome dysbiosis has previously been reported in spondyloarthritis (SpA) patients and could be critically involved in the pathogenesis of this disorder. The objectives of this study were to further characterize the microbiota structure in SpA patients and to investigate the relationship between dysbiosis and disease activity in light of the putative influence of the genetic background.MethodsShotgun sequencing was performed on fecal DNA isolated from stool samples from 2 groups of adult volunteers: SpA patients (n = 102) and healthy controls (n = 63). A subset of the healthy controls comprised the age‐matched siblings of patients whose HLA–B27 status was known. Changes in gut microbiota composition were assessed based on species diversity, enterotypes, and taxonomic and functional differences.ResultsDysbiosis was confirmed in SpA patients as compared to healthy controls. The restriction of microbiota diversity was detected in patients with the most active disease, and the abundance of several bacterial species was correlated with Bath Ankylosing Spondylitis Disease Activity Index score. Among healthy controls, significant differences in microbiota composition were also detected between the HLA–B27–positive and the HLA–B27–negative siblings of SpA patients. We highlighted a decreased abundance of several species of bacteria in SpA patients, especially those bacteria belonging to the Clostridiales order. Among the few species of bacteria showing increased abundance, Ruminococcus gnavus was one of the top differentiating species.ConclusionThese findings reveal that genetic background and level of disease activity are likely to influence the composition of the gut microbiota of patients with SpA. It may be appropriate for further research on chronic arthritis to focus on these key parameters.
Phosphatidylinositol 3‐Kinase δ Deficiency Protects From Antimyeloperoxidase Vasculitis
Authors: Flórez‐Barrós Fernanda , Freeley Simon , Tham El Li , Robson Michael G. 
Published: July 2022

ObjectiveAntineutrophil cytoplasmic antibody–associated vasculitis (AAV) is a systemic autoimmune disease in which glomerulonephritis is an important manifestation. Antibodies against myeloperoxidase (MPO) or proteinase 3 are thought to be important in pathogenesis. Phosphoinositide 3‐kinase δ (PI3Kδ) mediates a number of effects in lymphocytes, but its role in myeloid cell responses is less clear. Therefore, this study was undertaken to assess this in a preclinical model of glomerulonephritis induced by the transfer of antibodies to MPO.MethodsD910A mice with inactive PI3Kδ were compared with wild‐type controls. Disease protocols allowed for a comparison of experimental groups in the setting of both mild and more severe disease. Adoptive transfer experiments were performed, with flow cytometric analysis of digested kidneys taken at the end of the experiment.ResultsWith mild disease, D910A mice had fewer glomerular macrophages, fewer glomerular neutrophils, and reduced albuminuria compared with wild‐type controls. With more severe disease, they also had fewer glomerular crescents and lower serum creatinine levels, indicating protection from acute kidney injury. Adoptive transfer experiments showed a defect in the recruitment of D910A monocytes to the diseased kidney.ConclusionMice with inactive PI3Kδ were protected from anti‐MPO vasculitis. This is due to cell intrinsic defect in the recruitment of monocytes to the kidney. These findings suggest that PI3Kδ is a potential therapeutic target in AAV.
A spatial model to jointly analyze self‐reported survey data of COVID‐19 symptoms and official COVID‐19 incidence data
Authors: Vranckx Maren , Faes Christel , Molenberghs Geert , Hens Niel , Beutels Philippe , Van Damme Pierre , Aerts Jan , Petrof Oana , Pepermans Koen , Neyens Thomas 
Published: July 2022

AbstractThis work presents a joint spatial modeling framework to improve estimation of the spatial distribution of the latent COVID‐19 incidence in Belgium, based on test‐confirmed COVID‐19 cases and crowd‐sourced symptoms data as reported in a large‐scale online survey. Correction is envisioned for stochastic dependence between the survey's response rate and spatial COVID‐19 incidence, commonly known as preferential sampling, but not found significant. Results show that an online survey can provide valuable auxiliary data to optimize spatial COVID‐19 incidence estimation based on confirmed cases in situations with limited testing capacity. Furthermore, it is shown that an online survey on COVID‐19 symptoms with a sufficiently large sample size per spatial entity is capable of pinpointing the same locations that appear as test‐confirmed clusters, approximately 1 week earlier. We conclude that a large‐scale online study provides an inexpensive and flexible method to collect timely information of an epidemic during its early phase, which can be used by policy makers in an early phase of an epidemic and in conjunction with other monitoring systems.
Teaching social initiations to elementary‐aged children with autism: A systematic review
Authors: Aal Ismail Hazim , Weglarz‐Ward Jenna M. , Sarisahin Suheyla 
Published: July 2022

AbstractChildren initiate social interactions to greet, ask questions, invite peers to play, and for many other purposes. However, failure to initiate social interactions is one of the social communication criteria that are required to diagnose autism spectrum disorder (ASD) and may limit social opportunities for children with ASD. Several researchers examined different interventions to teach social initiations to elementary‐aged children with ASD. The purpose of this systematic review was to examine the interventions that were used to teach social initiations to elementary‐aged children with ASD and their outcomes in social initiations, maintenance, generalization, and social validity. The reviewed interventions were generally helpful in teaching, generalizing, and maintaining social initiations for elementary‐aged children with ASD. Although limited, social validity evaluations support the interventions, target behaviors, and/or outcomes. Gaps and implications for professionals and researchers were discussed.
On the structures and luminescence properties of Eu3+‐doped Li2CaGeO4, Ca2GeO4, and Ca5Ge3O11 compounds
Authors: Koseva Iovka , Nikolov Velin , Nikolova Rosica , Tzvetkov Peter , Ivanov Petar , Petrova Petia , Tomova Reni , Kuvandjiev Nikola , Tarassov Mihail 
Published: July 2022

AbstractPowder samples of Li2CaGeO4, Ca2GeO4, and Ca5Ge3O11 doped by 0.5, 1, 2, 3, 4 and 5 at% Eu3+ relative to the Ca2+, were prepared using a conventional solid‐state synthesis technique. X‐ray diffraction (XRD) analyses confirmed obtaining the pure phases at all dopant concentrations. In parallel, single crystals of the three compounds with the experimentally found optimal Eu3+ concentration were grown using a flux method. Structural investigation on the single crystals were done with a special attention to the form of the Ca–O polyhedron, the mean Ca–O distance, the Ca–Ca distance in the structure, the distortion degree of the polyhedron, as well as the Eu–Ca substitution site. The main spectral characteristics were analyzed and several relationships between the structural and spectra features were found. The optimal dopant concentration was 3 at% for Ca2GeO4 and 4at% for Ca5Ge3O11 and Li2CaGeO4. Commission Internationale de l'éclairage coordinates of the samples showed emission colours in the red region close to the standard red coordinates and slightly influenced by the active ion concentration. The obtained results showed that europium‐doped Li2CaGeO4, Ca2GeO4, and Ca5Ge3O11 could be used as red phosphors.
Transport and mobility decisions of consumers with disabilities
Authors: Mogaji Emmanuel , Bosah Genevieve , Nguyen Nguyen Phong 
Published: July 2022

AbstractPeople with disabilities are the world's largest minority stakeholder group, and they continue to face significant challenges in every aspect of their lives. This study explored the transport and mobility decisions of consumers with disabilities (CWDs) in the context of Nigeria, one of the world's largest developing countries, using the conservation of resources theory and the intersection of travel decisions, disability and country context regarding consumer behaviour. A total of 32 individuals with varying disabilities were interviewed. A thematic analysis of qualitative data revealed that CWDs make travel decisions based on their ability, as well as the availability, accessibility, affordability and reliability of different modes of transport. This study presents a conceptual framework illustrating the transport and mobility decisions of CWDs and highlights practical implications for various stakeholders.
PROTOCOL: School‐based language, math, and reading interventions for executive functions in children and adolescents: A systematic review
Authors: Dietrichson Jens , Thomsen Morten Kjær , Seerup Julie Kaas , Strandby Martin Williams , Viinholt Bjørn Christian Arleth , Bengtsen Elizabeth 
Published: July 2022

AbstractThis is the protocol for a Campbell systematic review. Our primary objective for this systematic review is to examine if preschool and school‐based interventions aimed at improving language, literacy, and/or mathematical skills increase children's and adolescents' executive functions. As a secondary objective, we will examine how the effects of language, literacy, and mathematics interventions on executive functions are moderated by the subject of the intervention, child age or grade, the type of EF measured, and the at‐risk status of participants. We will also explore how the effects are moderated by other study characteristics, and estimate the effects of the included interventions on language, literacy, and mathematical skills.
PROTOCOL: Gender transformative approaches in agriculture for women's empowerment: A systematic review
Authors: Singh Sabina , Mohan Ashima , Saran Ashrita , Puskur Ranjitha , Mishra Avni , Etale Linda , Cole Steven Michael , Masset Edoardo , Waddington Hugh Sharma , MacDonald Heather , White Howard 
Published: July 2022

AbstractThis is the protocol for a Campbell systematic review. The objective of this systematic review is to assess the effectiveness of interventions with gender transformative approach (GTA) components in improving women's empowerment in low‐ and middle‐income countries, and to curate evidence on the mechanisms through which GTA works to improve women's empowerment in agriculture.
Phase 1 Study Evaluating Pharmacokinetics and Tolerability of Ofatumumab Combined With Bendamustine in Patients With Indolent B‐Cell Non‐Hodgkin's Lymphoma
Authors: Forero‐Torres Andres , Chandler Jason Claud , Iyer Swaminathan P. , Kanate Abraham S. , Quinlan Michelle , Hoever Petra , Izquierdo Miguel , Davis Jaclyn , Madan Sumit 
Published: July 2022

AbstractThe pharmacokinetics (PK) and safety of ofatumumab and bendamustine alone and in combination were evaluated in patients with treatment‐naive or relapsed indolent B‐cell non‐Hodgkin lymphoma (iNHL). Patients were randomly assigned to ofatumumab and bendamustine or ofatumumab alone. Ofatumumab PK concentration profiles and parameters were similar, alone or in combination with bendamustine. A decrease of 14% in the maximum observed plasma concentration (Cmax) and 15% in the area under the plasma concentration–time curve (AUC) from time 0 to the last measurable concentration sampling time (AUClast) was observed for ofatumumab coadministered with bendamustine, which was not considered clinically relevant. Bendamustine PK concentration profiles and parameters were similar with or without ofatumumab. The most frequent treatment‐related adverse event was infusion‐related reaction in 53% in the combination arm and 47% in the ofatumumab arm. No relevant drug‐drug interaction was observed between ofatumumab and bendamustine. Ofatumumab alone or in combination with bendamustine had a manageable safety profile.