bluuebunny/crossref_metadata_2025_split huggingface dataset:
Intensive Care Unit–Acquired Weakness in Patients With COVID-19: Occurrence and Associated Factors
Authors: Schmidt Débora , Piva Taila Cristina , Glaeser Sheila Suzana , Piekala Daniele Martins , Berto Paula Pinheiro , Friedman Gilberto , Sbruzzi Graciele 
Published: February 2022

Abstract

Objective
The primary objective of this study was to identify the occurrence and factors associated with intensive care unit (ICU)-acquired weakness (ICUAW) in patients with COVID-19. Secondarily, we monitored the evolution of muscle strength and mobility among individuals with ICUAW and those without ICUAW and the association of these variables with length of stay, mechanical ventilation (MV), and other clinical variables.

Methods
In this prospective observational study, individuals admitted to the ICU for &gt;72 hours with COVID-19 were evaluated for muscle strength and mobility at 3 times: when being weaned from ventilatory support, discharged from the ICU, and discharged from the hospital. Risk factors for ICUAW were monitored.

Results
The occurrences of ICUAW at the 3 times evaluated among the 75 patients included were 52%, 38%, and 13%. The length of the ICU stay (29.5 [IQR = 16.3–42.5] vs 11 [IQR = 6.5–16] days), the length of the hospital stay (43.5 [IQR = 22.8–55.3] vs 16 [IQR = 12.5–24] days), and time on MV (25.5 [IQR = 13.8–41.3] vs 10 [IQR = 5–22.5] days) were greater in patients with ICUAW. Muscle strength and mobility were lower at all times assessed in patients with ICUAW. Bed rest time for all patients (relative risk = 1.14; 95% CI = 1.02 to 1.28) and use of corticosteroids (relative risk = 1.01; 95% CI = 1.00 to 1.03) for those who required MV were factors independently associated with ICUAW. Muscle strength was found to have a positive correlation with mobility and a negative correlation with lengths of stay in the ICU and hospital and time on MV.

Conclusion
The occurrence of ICUAW was high on patients’ awakening in the ICU but decreased throughout hospitalization; however, strength and mobility remained compromised at hospital discharge. Bed rest time and use of corticosteroids (for those who needed MV) were factors independently associated with ICUAW in patients with COVID-19.

Impact
Patients who had COVID-19 and developed ICUAW had longer periods of ICU stay, hospital stay, and MV. Bed rest time and use of corticosteroids (for those who required MV) were factors independently associated with ICUAW.
Factors enabling social impact: The importance of institutional entrepreneurship in social science research
Authors: Reale Emanuela 
Published: February 2022

Abstract
This paper wants to shed light on organizational factors as conditions for the impact of academic research in social sciences. Organizations play a role as enablers of social impact, providing conditions that improve the probability of impacting on society. We try to ascertain whether this role is supported and stimulated through institutional entrepreneurship, changing the institutions’ organizational features, ideas, and beliefs to increase productive interactions and knowledge translation. Our work centres on exploring the actors’ social position and their ability to introduce changes that are likely to permanently engage the organizations in the pursuit of social impact and possibly support it in the long run. The empirical basis consists of three case studies about research projects in the social sciences, which brought together academic researchers from different universities and stakeholders. The analysis demonstrates that understanding impact requires adopting a broader perspective, considering also the transformations emerging at the organizational level.
Characterization of Six Partial Resistance Genes and One Quantitative Trait Locus to Blast Disease Using Near Isogenic Lines with a Susceptible Genetic Background of Indica Group Rice (Oryza sativa)
Authors: Saito Hiroki , Tomita Asami , Yoshida Tomofumi , Nakamura Mitsuru , Suzuki Taro , Ikeda Akihiro , Kato Takahiro , Nakajima Yasunori , Tanimoto Ryo , Tani Toshio , Hayashi Nagao , Hirabayashi Hideyuki , Ando Ikuo , Fukuta Yoshimichi 
Published: February 2022

Seven near isogenic lines (NILs) for six partial blast-resistance genes— Pi35, pi21, Pi37(t)( Pi37-KRIL17), Pb1, and Pi34 (two: Pi34-Chubu32 and Pi34-Chugoku40, originating from different Japonica Group rice lines, ‘Chubu 32’ and ‘Chugoku 40’, respectively)—and one quantitative trait locus (QTL), PiPHL9, derived from Japonica Group line ‘Hokkai PL9’, were developed in rice ( Oryza sativa L.). These NILs have the genetic background of an Indica Group susceptible line ‘US-2’, which does not harbor complete resistance genes and can clarify the effects of partial resistance genes and the QTL. These NILs and US-2 were used to determine the effects of the partial resistance genes and the QTL based on the results of an inoculation test for leaf blast using international standard differential blast isolates in the young seedling stage and a natural infection test in the mature stage after heading at a blast field. The NILs produced mainly moderate reactions in the inoculation test and rarely exhibited “resistant” and “susceptible” reactions. Each of the partial resistance genes and the QTL had different effects in panicle blast. Two genes, Pi35 and Pb1, were the most effective with respect to resistance, followed by Pi37-KRIL17. Pi34-Chugoku40 was the weakest. The effects of pi21, Pi34-Chubu32, and PiPHL9 varied among cultivation seasons and could be easily affected by environmental conditions. This is the first report clarifying the effects of partial resistance genes without the major complete genes, which will be helpful for advanced genetic and pathological studies and as a source of genes for rice breeding. [Formula: see text] Copyright © 2022 The Author(s). This is an open access article distributed under the CC BY-NC-ND 4.0 International license .
Association between placental global DNA methylation and blood pressure during human pregnancy
Authors: Putra Sulistyo E. Dwi , Reichetzeder Christoph , von Websky Karoline , Neuber Corinna , Halle Horst , Kleuser Burkard , Krämer Bernhard K. , Hocher Berthold 
Published: February 2022

Objective:
Gene-specific placental DNA methylation patterns differ between normal pregnancies and pregnancies complicated by hypertension. However, whether global placental DNA methylation is associated with maternal blood pressure remains controversial.

Methods:
Using multiple linear regression models, we analysed the association between maternal mean arterial pressure (MAP) at the third trimester of pregnancy and global DNA methylation in the placenta in 922 mothers using LC-ESI-MS/MS. To better characterize the contribution of genetic or epigenetic mechanisms, we performed isolated analyses in mothers with and without a family history of hypertension.

Results:
Mean placental global DNA methylation was 3.00 ± 0.46%. A significant negative correlation between placental global DNA methylation and mean arterial blood pressure (MAP) in the third trimester could be observed (P = 0.023, r = -0.075). This association remained significant after adjusting for confounders. In placenta samples from mothers with a family history of hypertension, mean maternal MAP was higher (86.1 ± 8.1 vs. 84.6 ± 7.5, P < 0.01) and placental global DNA methylation was lower (2.94 ± 0.43 vs. 3.04 ± 0.47, P < 0.01) compared with samples without a family history of hypertension. Furthermore, the significant independent negative correlation between global placental DNA methylation and MAP was only found in mothers without a family history of hypertension.

Conclusion:
This study showed an independent negative correlation between placental global DNA methylation and maternal MAP in mothers without a family history of hypertension.
Nurses' Practices With Persons Experiencing Opioid Use Disorder
Authors: Sowicz Timothy Joseph , Huneycutt Brittany , Lee Jung Min 
Published: February 2022

Abstract
Millions of persons globally use opioids, and more than two million persons in the United States report having opioid use disorder (OUD). Increases in overdose deaths associated with opioids have led to a declaration of an opioid epidemic in the United States. Many healthcare professionals are involved in the treatment of persons experiencing OUD; several discipline-specific (e.g., medicine and public health) interventions are available. Nurses comprise large portions of the global and national healthcare workforces; therefore, investigating their unique, disciplinary contributions for addressing the opioid epidemic is warranted. This narrative literature review was undertaken to understand nurses' actions, practices, and work with persons with OUD. Using several databases and keywords, 21 research studies met the inclusion criteria. Most studies used qualitative designs; most quantitative studies were nonexperimental. The studies were conducted mostly in Europe and North America. Descriptions of nurses' practices with people with OUD varied in their levels of specificity and aligned well with the scopes of practice outlined by the American Nurses Association and the International Nurses Society on Addictions. The absence of theories (specifically nursing theories) used in the studies was notable. Theoretically informed studies that move beyond descriptions of nurses' practices are needed to advance discipline-specific knowledge and to showcase the unique contributions of nurses who make significant contributions to lessening adverse outcomes associated with OUD.
Jordanian University Students' Lived Experience of Misusing Amphetamine (Captagon)
Authors: Al Omari Omar , Wynaden Dianne , Alkhawaldeh Abdullah , Alhalaiqa Fadwa , Al Dameery Khloud , Roach Erna Judith , Sunderraj Sheeba John , Khalaf Atika 
Published: February 2022

Abstract

Background
Substance misuse is a growing problem among Jordanian university students.

Purpose
The aim of this study was to explore the lived experiences of university students who misuse Captagon (amphetamines).

Methods
The interpretative phenomenological analysis methodology was used. In-depth face-to-face interviews were conducted with 10 Jordanian university students, aged 17–22 years, who were using Captagon (amphetamines) for the last 6 months.

Results
Three major themes detailed participants' experiences with Captagon: (a) causes for use, (b) effects of taking amphetamines, and (c) seeking help behaviors and support. Participants who experienced academic and personal stress sought help from friends, who provided them with Captagon pills as a way to overcome their life challenges. Initially, taking Captagon provided participants with a sense of control, but it did not solve their problems. Later or as the days passed by, they experienced increased level of stress, felt disorganized in a way that they missed classes, and were being socially isolated. Participants finally sought community help for their problem, but this was difficult because of stigmatizing attitudes in their community toward substance misuse.

Conclusions
Increasing university students' knowledge about the negative consequences of substance misuse and raising awareness of strategies to address the problem will help young people to make more informed choices, because today's young generation are tomorrow's citizens.
Hyperbaric Oxygen to Assist Adults With Opioid Use Disorder in Reducing Methadone Dose
Authors: Wilson Marian , Odom-Maryon Tamara , Stanek Karen , Roush Trevor , Muriungi Joseph , Jesse Alvina , Quock Raymond M. , Layton Matthew 
Published: February 2022

Abstract
Opioid withdrawal symptoms can interfere with substance use disorder treatment goals. This study investigated the acceptability, feasibility, and treatment effects of hyperbaric oxygen therapy (HBOT) as an adjunct to reduce withdrawal symptoms for adults initiating a medically supervised methadone dose reduction. Adults prescribed methadone for opioid use disorder were randomized into either a hyperbaric oxygen group (n = 17) or an attention control group (n = 14). The study site was an outpatient opioid treatment program in the northwestern United States. Participants were asked to attend five consecutive daily 90-minute HBOT sessions offered at 2.0 atmospheres absolute with 100% oxygen in a pressurized chamber. Treatment attendance and reported satisfaction were measures of acceptability and feasibility. Medication doses were tracked posttreatment at 1 week, 1 month, and 3 months. Withdrawal symptoms were assessed at baseline and daily during the 5-day intervention period. After randomization, 13 (76.5%) followed through with medical screening and HBOT sessions, and of those, nine (69.2%) completed all five 90-minute HBOT sessions. At 3 months, the treatment group maintained, on average, a 4.3-mg methadone dose reduction compared with an average reduction of 0.25 mg for control group participants. Opioid withdrawal symptoms were reduced after Day 1 of HBOT by twice as much, on average, compared with the control condition. Satisfaction surveys found participants were generally satisfied with ease and comfort of the treatment. The evidence that HBOT is an acceptable, feasible adjunct warrants future trials to determine more conclusively effects on withdrawal symptoms associated with methadone dose taper.
Acute Vulvar Aphthous Ulceration After COVID-19 Vaccination: 3 Cases
Authors: Wijaya Marlene , Zhao Cathy , Forward Emily , Nguyen Yvonne , Kherlopian Ashod , Jollow David , Trujillo Dalia Cardenes , Fischer Gayle 
Published: February 2022

Objective
We present a case series of acute vulvar aphthosis immediately following COVID-19 vaccination.

Materials and Methods
We describe 3 cases of acute vulvar aphthosis following Pfizer Comirnaty BNT162b2 mRNA and AstraZeneca (Vaxzevria) ChAdOx1 nCoV-19 COVID-19 vaccination in adolescent girls.

Results
All patients developed vulvar aphthosis within a few days after receiving COVID-19 vaccination. The onset of vulvar aphthosis was observed to correlate with the dosing schedule known to produce the highest likelihood of adverse effects, first dose in AstraZeneca (Vaxzevria) ChAdOx1 nCoV-19 and second dose in Pfizer Comirnaty BNT162b2 mRNA COVID-19 vaccine. Two patients required oral prednisolone and hospital admission for indwelling urinary catheterization due to urinary retention. Full disease resolution with no sequalae was achieved in all three patients.

Conclusions
Clinicians should be aware of the possible risk of vulvar aphthosis after COVID-19 vaccine administration. Nevertheless, its occurrence should not prevent affected patients from receiving future doses of COVID-19 vaccines, as the mortality and morbidity of COVID-19 infection significantly outweigh the risk of vulvar aphthosis recurrence.
Cardiac lymphatics: state of the art
Authors: Heron Coraline , Ratajska Anna , Brakenhielm Ebba 
Published: February 2022

Purpose of review
The beneficial role of cardiac lymphatics in health and disease has begun to be recognized, with both preclinical and clinical evidence demonstrating that lymphangiogenesis is activated in cardiovascular diseases. This review aims to summarize our current understanding of the regulation and impact of cardiac lymphatic remodeling during development and in adult life, highlighting emerging concepts regarding distinguishing traits of cardiac lymphatic endothelial cells (LEC).

Recent findings
Genetic lineage-tracing and clonal analyses have revealed that a proportion of cardiac LECs originate from nonvenous sources. Further, these sources may vary between different regions of the heart, and could translate to differences in LEC sensitivity to molecular regulators. Several therapeutic approaches have been applied to investigate how lymphatics contribute to resolution of myocardial edema and inflammation in cardiovascular diseases. From these studies have emerged novel insights, notably concerning the cross-talk between lymphatics and cardiac interstitial cells, especially immune cells.

Summary
Recent years have witnessed a significant expansion in our knowledge of the molecular characteristics and regulation of cardiac lymphatics. The current body of work is in support of critical contributions of cardiac lymphatics to maintain both fluid and immune homeostasis in the heart.
Resources for Improving Pediatric Readiness and Quality of Care in Rural Communities and Emergency Departments
Authors: Kothari Shikha Yashwant , Haynes Sarah C. , Sigal Ilana , Magana Julia N. , Ruttan Timothy , Kuppermann Nathan , Horeczko Timothy , Ludwig Lorah , Karsteadt Larry , Chapman Wendy , Pinette Vickie , Marcin James P. 
Published: February 2022

Objectives
To share the process and products of an 8-year, federally funded grant from the Health Resources and Services Administration Emergency Medical Services for Children program to increase pediatric emergency readiness and quality of care provided in rural communities located within 2 underserved local emergency medical services agencies (LEMSAs) in Northern California.

Methods
In 2 multicounty LEMSAs with 24 receiving hospital emergency departments, we conducted focus groups and interviews with patients and parents, first responders, receiving hospital personnel, and other community stakeholders. From this, we (a regional, urban children's hospital) provided a variety of resources for improving the regionalization and quality of pediatric emergency care provided by prehospital providers and healthcare staff at receiving hospitals in these rural LEMSAs.

Results
From this project, we provided resources that included regularly scheduled pediatric-specific training and education programs, pediatric-specific quality improvement initiatives, expansion of telemedicine services, and cultural competency training. We also enhanced community engagement and investment in pediatric readiness.

Conclusions
The resources we provided from our regional, urban children's hospital to 2 rural LEMSAs facilitated improvements in a regionalized system of care for critically ill and injured children. Our shared resources framework can be adapted by other regional children's hospitals to increase readiness and quality of pediatric emergency care in rural and underserved communities and LEMSAs.
Aligning Provider Prescribing With Guidelines for Soft Tissue Infections
Authors: Kovaleski Christopher , Courter Joshua D. , Ghulam Enas , Hagedorn Philip A. , Haslam David B. , Kurowski Eileen Murtagh , Rudloff James , Szczesniak Rhonda , Dexheimer Judith W. 
Published: February 2022

Objective
Despite evidence-based guidelines, antibiotics prescribed for uncomplicated skin and soft tissue infections can involve inappropriate microbial coverage. Our aim was to evaluate the appropriateness of antibiotic prescribing practices for mild nonpurulent cellulitis in a pediatric tertiary academic medical center over a 1-year period.

Methods
Eligible patients treated in the emergency department or urgent care settings for mild nonpurulent cellulitis from January 2017 to December 2017 were identified by an International Classification of Diseases, Tenth Revision, code for cellulitis. The primary outcome was appropriateness of prescribed antibiotics as delineated by adherence with the Infectious Diseases Society of America guidelines. Secondary outcomes include reutilization rate as defined by revisit to the emergency department/urgent cares within 14 days of the initial encounter.

Results
A total of 967 encounters were evaluated with 60.0% overall having guideline-adherent care. Common reasons for nonadherence included inappropriate coverage of MRSA with clindamycin (n = 217, 56.1%) and single-agent coverage with sulfamethoxazole-trimethoprim (n = 129, 33.3%). There were 29 revisits within 14 days of initial patient encounters or a reutilization rate of 3.0%, which was not significantly associated with the Infectious Diseases Society of America adherence.

Conclusions
Our data show antibiotic prescription for nonpurulent cellulitis as a potential area of standardization and optimization of care at our center.
Extensive Gingivoperiosteoplasty Versus Secondary Alveolar Bone Grafting in Patients With Complete Bilateral Cleft Lip and Palate During the Mixed Dentition Period
Authors: Lu Ting-Chen , Bhandari Kishor , Yao Chuan-Fong , Tangco Ivy , Bajracharya Manish , Chen Philip Kuo-Ting 
Published: February 2022

Background
The concept of gingivoperiosteoplasty (GPP) in the mixed dentition stage as compared with secondary alveolar bone grafting (ABG) in management of alveolar cleft has not been much discussed upon. The authors present the experience with extensive GPP and ABG in the mixed dentition stage in complete bilateral alveolar cleft cases.

Methods
A retrospective review of nonsyndromic patients with complete bilateral alveolar cleft operated on with either GPP or ABG (iliac crest) in the mixed dentition stage with at least 1-year follow-up was performed. Dental occlusal radiographs were evaluated for level of bone gain using Bergland and Witherow scales. Statistical evaluation of clinical success and procedure-related complications was conducted using χ2 test and odds ratio.

Results
Twenty-four patients in the GPP group and 20 in the ABG group were comparatively studied. Clinical success rate as indicated by Bergland scales I and II (87.5% in GPP vs 82.5% in ABG; P = 0.731), complication rate (20.83% in GPP vs 30% in ABG; P = 0.484), and status of canine eruption showed no significant differences in clinical outcomes in both groups.

Conclusions
The technique of extensive GPP as described by authors shows equal efficacy to secondary ABG for management of bilateral alveolar clefts during the mixed dentition period.
Double Fillet Flap for End-Stage Pelvic Pressure Injuries in a Paraplegic Patient
Authors: Wang Yu-Chi , Lin Tzu-Yu , Huang Shu-Hung 
Published: February 2022

Abstract
Recurrent pelvic pressure injuries are common among paraplegic patients with spinal cord injury. Most of them experienced multiple surgical treatments because of recurrence. Based on the “spare part” concept, the double fillet flap is feasible when all other reconstructive procedures were exhausted. In this case report, we present the double fillet flap technique to manage recurrent extended pelvic pressure ulcers in a paraplegic spinal cord injury patient.