bluuebunny/crossref_metadata_2025_split huggingface dataset:
Accelerated radiotherapy in patients over sixty years old after mastectomy: Acute and one-year physician-assessed toxicity and health-related quality of life
Authors: Vakaet Vincent , Van Hulle Hans , Quataert Viktor , Deseyne Pieter , Schoepen Max , Paelinck Leen , Post Giselle , Van Greveling Annick , Speleers Bruno , Mareel Marc , De Neve Wilfried , Monten Chris , Veldeman Liv 
Published: May 2022

INTRODUCTION: Postmastectomy radiotherapy reduces the risk of locoregional recurrence in breast cancer patients. The first results on accelerated radiotherapy in five fractions after breast conserving surgery are promising. The data on postmastectomy radiotherapy in five or six fractions is limited. We now present the data on acute and one-year toxicity and health related quality of life (HRQoL) after postmastectomy radiotherapy in patients of sixty years or older. METHODOLOGY: 119 patients received five fractions of 5.7 Gy to the chest wall and five fractions of 5.4 Gy to the lymph nodes over ten to twelve days. Physician-assessed toxicity were scored using the Common Terminology Criteria for Adverse Events version 4.03 toxicity scoring system and the LENT-SOMA scale. Fatigue was measured by the Multidimensional Fatigue Inventory (MFI-206). HRQoL was assessed using the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire the breast cancer specific module and the BREAST-Q questionnaire. RESULTS: Fatigue and edema were the most frequently observed physician-assessed toxicities. One year after radiotherapy only 12.9% experienced a clinically important deterioration in chest wall symptoms and in 22.9% of the patients were improved. Future perspective at one year after radiotherapy was improved in 40.0% of the patients. Patient-reported fatigue showed the greatest improvement. CONCLUSION: Accelerated radiotherapy should be considered to minimize the burden of breast cancer treatment, especially in older patients.
The value of contrast-enhanced ultrasound in the diagnosis of BI-RADS-US 4a lesions less than 2 cm in diameter
Authors: Yu Mei-qin , Zhang Li-li , Jiang Li-ping , Zhou Ai-yun 
Published: May 2022

BACKGROUND: Breast cancer is the most common malignant tumor in women. Early diagnosis of benign and malignant breast tumors is of great significance. OBJECTIVE: To retrospectively analyze the value of contrast-enhanced ultrasonography (CEUS) in the diagnosis of Breast Imaging-Reporting and Data System (BI-RADS) 4a breast lesions less than 2 cm in diameter. METHODS: CEUS was performed for 143 breast masses less than 2 cm in diameter that were diagnosed as BI-RADS 4a by ultrasound and reclassified. Considering pathological diagnosis as the gold standard, the sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of reclassified lesions after CEUS for the diagnosis of benign and malignant masses were analyzed. RESULTS: BI-RADS 4a breast masses with a diameter less than 2 cm ( n = 143) were confirmed by pathology; 103 and 40 were classified as benign and malignant, respectively. The sensitivity, specificity, PPV, and NPV of CEUS for the diagnosis were 90%, 86%, 72%, and 95%, respectively. The area under the receiver operating characteristic (ROC) curve of CEUS for the diagnosis of benign and malignant tumors after CEUS was 0.904. CONCLUSION: CEUS can help to improve the diagnostic accuracy of BI-RADS 4a masses with a diameter less than 2 cm.
Challenges and trends in the use of technology by hearing impaired students in higher education
Authors: Fernández Batanero José María , Rueda Montenegro Marta , Cerero Fernández José , García Alonso Santiago 
Published: May 2022

BACKGROUND: The presence of students with hearing impairment in the university context has increased in recent years. OBJETIVE: The aim of this study is to provide the academic community with an overview of research on ICT as a support for students with hearing impairment in higher education settings. METHOD: The data were obtained through a systematic literature review, covering the period from 2010 to 2020, in three leading scientific databases in the world of education (Web of Science, Scopus and ERIC). The sample consisted of 17 studies out of an initial 190. Through a descriptive and quantitative methodology, the most significant bibliometric data are presented, and by means of bibliometric maps, a methodology based on co-word analysis, clustering techniques and visualisation techniques is applied in order to determine the fields of study and research. RESULTS: The findings show a lack of research that addresses the use of ICT for students with hearing impairment, as well as the effectiveness of these tools. CONCLUSIONS: It is necessary to approach research from a systemic and holistic perspective in order to improve the education of these students.
LONG-TERM RADICAL PROSTATECTOMY ONCOLOGIC OUTCOMES IN PATIENTS WITH CLINICALLY LOCALLY ADVANCED PROSTATE CANCER: A SINGLE-CENTER STUDY
Authors: Grygorenko V. , Afanasiev Ye. , Danylets R. , Vikarchuk M. , Kosyuchno M. , Pasichnyk S. 
Published: May 2022

Background: Prostate cancer (PCa) is the second most frequently diagnosed cancer in males worldwide and placed fifth in cancer mortality among males. Between 14–24% of PCa patients have newly diagnosed advanced stages, which paradoxically has remained stable over time. Aim: To estimate and compare long-term radical prostatectomy (RP) oncologic outcomes in patients with clinically locally advanced prostate cancer (LAPCa), to determine the prognostic significance of common clinical-pathological parameters. Patients and Methods: The study included 105 patients with LAPCa who underwent RP with extended pelvic lymphadenectomy between September 2003 — April 2015. Kaplan — Meier method was used for calculating biochemical recurrence- (BRFS), progression-free- (PFS), overall (OS), and prostate cancer-specific survival (PCSS) rates. Analyses of features associated with outcomes were conducted using Cox proportional hazards regression model. Results: Patients from cT3b group had worse PFS, OS and PCSS rates in comparison with cT3a, while there was no significant difference in BRFS rates. Preoperative serum prostate-specific antigen level (hazard ratio (HR) 1.023, 95% confidence interval (CI): 1.014–1.033, p < 0.001), pT3a (HR 3,027, 95% CI: 1.449–7.096, p < 0.01), pT3b (HR 2.792, 95% CI: 1.133–6.881, p < 0.05) pT4 stage (HR 31.12, 95% CI: 7.646–126.6 p < 0.001) and positive lymph nodes status (HR 6.503, 95% CI: 3.190–13.25, p < 0.001) were significant factors in BRFS. Preoperative serum prostate-specific antigen level (HR 1.018, 95% CI: 1.007–1.030, p = 0.001) and positive lymph nodes status (HR 3.191, 95% CI: 1.672–6.088, p < 0.001) were significant factors in PFS and PCSS. Conclusions: RP as the initial treatment option of multimodal therapy in the management of LAPCa patients demonstrates encouraging oncologic outcomes. Patients from the cT3b group had the worse rates of PFS, OS, and PCSS in comparison with the cT3a group. Heterogeneity of LAPCa patients’ outcomes reflects the insufficiency of the existing clinical risk classification for the prediction of systemic progression and cancer-specific survival.
EVALUATION OF 5-FLUOROURACIL-INDUCED CARDIOTOXICITY: ROLE OF CARDIAC BIOMARKERS
Authors: Moghaddam Zhaleh Karimi , Rostami Mina , Zeraatchi Alireza , Fallah Abadi Hamidreza , Karamitanha Farzaneh , Amirmoghaddami Hamidreza 
Published: May 2022

Background: Side effects of chemotherapy in cancer patients need to be investigated in more detail. Aim: To determine the incidence of cardiotoxicity in patients treated with different chemotherapy regimens containing 5-fluorouracil (5-FU) in Zanjan, Iran. Patients and Methods: In a prospective cohort study, patients with different types of solid gastrointestinal tumors who were candidates for 5-FU based chemotherapy regimens were enrolled. The study population consisted of 100 patients (48 females and 52 males) with a mean age of 63.99 ± 12.40 years. We measured serum cardiac troponin I (cTnI) levels before and during each chemotherapy cycle and determined the occurrence of cardiotoxicity in patients based on the levels of cTnI, clinical signs and symptoms as well as electrocardiogram findings. In addition, we assessed a history of diabetes, hypertension, smoking, dyslipidemia and previous chest radiation as potential risk factors for cardiotoxicity. Results: The incidence of cardiotoxicity was 8%, of which 5 patients were diagnosed with acute coronary syndrome, 2 patients with arrhythmias and one with hypotension. In addition, there was no significant association between studied risk factors and 5-FU induced cardiotoxicity. Conclusion: The incidence of cardiotoxicity in patients receiving 5-FU infusion regimens was notable. Thus, paying more attention to the 5-FU-induced cardiotoxicity is necessary in order to improve the prognosis of patients with cancer.
Non-Coding RNAs Delivery by Small Extracellular Vesicles and Their Applications in Ovarian Cancer
Authors: Liu Mu , Zhou Xiaofang , Tang Jie 
Published: May 2022

Ovarian cancer (OC) is the most fatal gynecological malignancy because of its early asymptomatic nature and acquired resistance to chemotherapy. Small extracellular vesicles (sEVs) are a heterogeneous group of biological vesicles with a diameter &lt;200 nm released by cells under physiological or pathological conditions. sEVs-derived non-coding RNAs (ncRNAs) are the essential effectors in the biological environment. sEVs-ncRNAs have critical roles in tumor progression via regulating mRNA expression of target cells to affect cell signaling. In addition, the status of parental cells can be disclosed via analyzing the composition of sEVs-ncRNAs, and their “cargoes” with specific changes can be used as key biomarkers for the diagnosis and prognosis of OC. Accumulating evidence has demonstrated that sEVs-ncRNAs are involved in multiple key processes that mediate the development of metastasis and chemotherapeutic resistance in OC: epithelial–mesenchymal transition; tumorigenicity of mesenchymal stem cells; immune evasion; angiogenesis. The nanomedicine delivery system based on engineering sEVs is expected to be a novel therapeutic strategy for OC. Insights into the biological roles of sEVs-ncRNAs in the invasion, metastasis, immune regulation, and chemoresistance of OC will contribute to discovery of novel biomarkers and molecular targets for early detection and innovative therapy. In this review, we highlight recent advances and applications of sEVs-ncRNAs in OC diagnosis and treatment. We also outline current challenges and knowledge gaps.
Surface Functionalization of SBA-15 for Immobilization of Myoglobin
Authors: Miao Hengmin , Li Maosheng , Wang Fang , Li Jiao , Lin Ying-Wu , Xu Jiakun 
Published: May 2022

Mesoporous molecular sieve SBA-15 was successfully modified with 3-aminopropyltriethoxysilane (APTES) and 3-glycidyloxypropyltrimethoxysilane (GPTMS). The functionalized SBA-15 were characterized by small-angle X-ray (SAXRD), thermogravimetric analysis (TG), N2 adsorption, and Fourier transformed infrared spectrum (FT-IR). APTES functionalized SBA-15 (named SBA-15-A) and GPTMS functionalized SBA-15 (named SBA-15-G) were used to immobilize myoglobin (Mb). The loading amounts of Mb by SBA-15-A and SBA-15-G were 511.2 and 547.8 mg/g, respectively, whereas only 359.6 mg/g was achieved by SBA-15. Mb/SBA-15-G and Mb/SBA-15-A demonstrated better reusability than SBA-15, retaining 84.6% and 82.7% of the initial activity after repeated use seven times. The Mb/SBA-15-A and Mb/SBA-15-G also exhibited improved thermal stability and storage stability.
Integrated Serum Pharmacochemistry and Network Pharmacology Approach to Explore the Effective Components and Potential Mechanisms of Menispermi Rhizoma Against Myocardial Ischemia
Authors: Wei Jinxia , Yu Yingying , Zhang Yue , Li Lingzhi , Li Xia , Shao Jia , Li Yubo 
Published: May 2022

Background: Myocardial ischemia (MI) is a leading cause of death worldwide. Menispermi Rhizoma is a traditional Chinese medicine that exerts a variety of beneficial pharmacological activities in many diseases, including MI.Purpose: Serum pharmacochemistry and network pharmacology were used to explore the material basis and mechanism of action of Menispermi Rhizoma against MI.Methods: The absorbed components of Menispermi Rhizoma in rat plasma were analyzed by ultra-performance liquid chromatography quadrupole time-of-flight tandem mass spectrometry (UPLC-Q-TOF/MS). The key components, targets, pathways, and interrelated information were obtained by network pharmacology. The potential effective components of Menispermi Rhizoma against MI were screened by methyl-thiazolyl-tetrazolium (MTT) assay, and the cardioprotective effect and mechanism of active components were verified by Western blotting and molecular docking.Results: In total, 25 absorbed components of Menispermi Rhizoma in plasma were identified. Network pharmacology revealed 81 major targets of Menispermi Rhizoma against MI, mainly involving the regulation of the PI3K/AKT and MAPK pathways. In vitro validation of H9c2 cells revealed that acutumine, daurisoline, dauricoside, and 6-O-demethylmenisporphine are the main bioactive components of Menispermi Rhizoma. The levels of lactate dehydrogenase, creatine kinase, and malondialdehyde (MDA) were significantly decreased by four alkaloids, whereas the activities of superoxide dismutase (SOD) and glutathione (GSH) were significantly increased. Four alkaloids effectively protected H9c2 cells against OGD-induced apoptosis by Hoechst/PI staining and flow cytometry assay. Western blotting results showed that the four alkaloids upregulated the expression ratio of Bcl-2/Bax and downregulated the expression levels of Cyt-C and cleaved caspase 3, which further supported the anti-cardiomyocyte apoptosis and antioxidative stress effect of Menispermi Rhizoma. Molecular docking confirmed that the four compounds were capable of binding to AKT1, MAPK1, EGFR, CASP3, and MAPK8 proteins, suggesting the protective effect of Menispermi Rhizoma on MI via PI3K/AKT, MAPK, and apoptosis pathways.Conclusion: Menispermi Rhizoma exerted cardioprotective effects through the effect characteristics: multiple-ingredient, multi-target, and multi-pathway. This research provided a reference for further mechanistic research on wider applications of Menispermi Rhizoma for MI treatment.
Synthesis and Bioactivities of Novel Galactoside Derivatives Containing 1,3,4-Thiadiazole Moiety
Authors: Shu Yafei , Chen Meihang , Lu Daowang , Zhou Zengyan , Yu Jianhong , Hu Xiaoling , Yang Jiaqin , Li Aiqin , Liu Jianglong , Luo Hairong 
Published: May 2022

A series of novel galactoside derivatives containing 1,3,4-thiadiazole moiety were synthesized, and the structure of them was verified by spectroscopy of NMR and HRMS, and antifungal and antibacterial activities of them were screened. The results showed that the newly synthesized compounds had good antifungal activities. Among them, Ⅲ16, Ⅲ17, and Ⅲ19 exhibited satisfactory activities against Phytophthora infestans (P. infestans), with EC50 values of 5.87, 4.98, and 6.17 μg/ml, respectively, which were similar to those of dimethomorph (5.52 μg/ml). Meanwhile, the title compounds also possessed certain antibacterial activities.
FuZhengHuaYuJiangZhuTongLuoFang Prescription Modulates Gut Microbiota and Gut-Derived Metabolites in UUO Rats
Authors: Chen Ziwei , Wu Shaobo , Zeng Yu , Chen Zejun , Li Xueying , Li Jing , He Long , Chen Ming 
Published: May 2022

BackgroundAlteration of intestinal flora and metabolites is closely related to chronic kidney disease (CKD) across early to advanced stages. FuZhengHuaYuJiangZhuTongLuoFang prescription (FZHY) is a Chinese herb that has been proven to effectively treat CKD, but the underlying mechanism is not clear.MethodsRats were subjected to intragastric treatment with FZHY 7, 14, and 21 days after unilateral ureteral obstruction (UUO) surgery, and kidney tissue, colon tissue, serum, and stool samples were collected.ResultsFZHY treatment effectively ameliorated UUO-induced renal function loss, renal injury and renal fibrosis, and colon tissue damage and fibrosis on day 7. The results of 16S flora analysis (day 7) showed that, compared with the UUO group, both the FZHY group and the sham group showed decreased levels of g_Monoglobus, g_Papillibacter, g_Eubacterium_nodatum, and g_Family_XIII_AD3011. Additionally, FZHY obviously induced the reduction of serum citrulline, glycoursodeoxycholic acid, 23-nordeoxycholic acid, 7-ketodeoxycholic acid, kahweol, lipoid B4, 4-(3,4-dihydro-2H-1,5-benzodioxepin-7-yl)-2-methyl-1,3-thiazole, taurolithocholic acid sodium salt, indoline-2-carboxylic acid, 5(S),15(S)-diHETE, and others and the increase of bilirubin, asparagine, and others, which were positively associated with the above four candidate bacteria. Moreover, FZHY increased the levels of ZO-1, occludin, and claudin-1 in the colonic mucosa and reduced the levels of CRP, TNF-α, IL-6, and IL-1 in the serum and LN, FN, Col-I, and Col-III in the tubulointerstitium of UUO rats on day 7.ConclusionOur study revealed that FZHY reduced kidney damage at the early stage of CKD by regulating the above four candidate bacteria biomarkers and gut-derived harmful metabolites, inhibiting the inflammation response and tubulointerstitial fibrosis, providing deep insight into CKD therapeutic strategy.
Immune Checkpoint Inhibitor-Associated Cardiotoxicity in Solid Tumors: Real-World Incidence, Risk Factors, and Prognostic Analysis
Authors: Chen Xue , Jiang Aimin , Zhang Rui , Fu Xiao , Liu Na , Shi Chuchu , Wang Jingjing , Zheng Xiaoqiang , Tian Tao , Liang Xuan , Ruan Zhiping , Yao Yu 
Published: May 2022

BackgroundImmune checkpoint inhibitors (ICIs) have achieved acknowledged progress in cancer therapy. However, ICI-associated cardiotoxicity as one of the most severe adverse events is potentially life-threatening, with limited real-world studies reporting its predictive factors and prognosis. This study aimed to investigate the real-world incidence, risk factors, and prognosis of ICI-related cardiotoxicity in patients with advanced solid tumors.MethodsElectronic medical records from patients with advanced solid tumors receiving ICIs in the First Affiliated Hospital of Xi’an Jiaotong University were retrospectively reviewed. All patients were divided into the cardiotoxicity group and control group, with logistic regression analysis being implemented to identify potential risk factors of ICI-related cardiotoxicity. Furthermore, survival analysis was also performed to investigate the prognosis of patients with ICI-related cardiotoxicity.ResultsA total of 1,047 participants were enrolled in this retrospective study. The incidence of ICI-related cardiotoxicity in our hospital is 7.0%, while grade 3 and above cardiotoxicity was 2.4%. The logistic regression analysis revealed that diabetes mellitus [odds ratio (OR):1.96, 95% confidence Interval (CI): 1.05–3.65, p = 0.034] was an independent risk factor, whereas baseline lymphocyte/monocyte ratio (LMR) (OR: 0.59, 95% CI: 0.36–0.97, p = 0.037) was the protective factor of ICI-related cardiotoxicity. Survival analysis indicated that severe cardiotoxicity (≥grade 3) was significantly correlated with bleak overall survival (OS) than mild cardiotoxicity (≤grade 2) (8.3 months vs. not reached, p = 0.001). Patients with ICI-related overlap syndrome had poorer overall survival than patients with mere cardiotoxicity (9.4 vs. 24.7 months, p = 0.033). However, the occurrence of ICI-related cardiotoxicity was not significantly associated with the OS of overall population with solid tumors. Subgroup analysis showed that lung cancer and PD-L1 usage were significantly correlated with a higher incidence of severe cases.ConclusionImmune checkpoint inhibitor-related cardiotoxicity is more common in the real-world setting than the previously published studies. Diabetes mellitus and baseline LMR are the potential predictive biomarkers of ICI-related cardiotoxicity. Although ICI-related cardiotoxicity is not correlated with the prognosis of these patients in our cohort, a systematic and comprehensive baseline examination and evaluation should be performed to avoid its occurrence.
New Paleomagnetic Constraints on the Early Cretaceous Paleolatitude of the Lhasa Terrane (Tibet)
Authors: Li Zhenyu , Ding Lin , Laskowski Andrew K. , Burke William B. , Chen Yaofei , Song Peiping , Yue Yahui , Xie Jing 
Published: May 2022

New zircon U-Pb dating results from the Zonggei Formation volcanics indicate that the volcanic rocks formed at ∼114–110 Ma. Paleomagnetic data, petrography, and rock magnetism confirm the primary nature of isolated characteristic remanent magnetizations carried by titanomagnetite and hematite. A statistical analysis of the combined results from the Zonggei and Duoni formations reveals a group-mean direction of D±ΔD = 0.4° ± 6.0°, I±ΔI = 22.2° ± 5.6°, α95 = 5.6°, k = 35.2 after bedding correction based on 20 group-mean directions. The corresponding paleopole was calculated to be λp = 70.3°N, φp = 270.5°E with A95 = 5.2°. The interpretation of our data alongside the Cenozoic data from the Tethyan Himalaya indicates that the India–Asia collision initiated by 61.7 ± 3.0 Ma at 13.0° ± 1.8°N, assuming a single-collision model. Intracontinental crustal shortening totaling 1,770 ± 470 km took place on the Asian side since the onset of India–Asia collision. Furthermore, the data show that the Neo-Tethys Ocean reached its maximum N-S width of 7,100 ± 530 km at ∼132 Ma and shrank to 6,400 ± 550 km by ∼115 ± 5 Ma. This is consistent with previous estimates based on the geophysical images of the subducted Neo-Tethyan slab beneath Eurasia.
Summer Temperature Reconstruction for the Source Area of the Northern Asian Great River Basins, Northern Mongolian Plateau Since 1190 CE and its Linkage With Inner Asian Historical Societal Changes
Authors: Chen Feng , Chen Youping , Davi Nicole , Zhang Heli 
Published: May 2022

Mid-to-high latitudes of Asia and its adjacent Arctic area are some of the most sensitive regions to climate warming in Eurasia, but spatio-temporal temperature variation over this region is still limited by a lack of long-term temperature records. Here, June-July temperature reconstructions are developed from a Larix sibirica composite chronology that presents a stable positive linkage with large-scale recorded temperatures and spans 1190–2019 CE for the source area of the Northern Asian great river Basins, northern Mongolian Plateau, Inner Asia. The warmest reconstructed period and low summer sea ice extent in the Arctic Ocean over the past 830 years was estimated to occur in the late twentieth century (1990s–present), with a mean temperature (15.2°C) higher than the long-term mean (13.9°C) of 1190–2019 CE, which is linked with the rapid increase in global temperature. A relationship also exists between the reconstructed temperature and the AMO index, suggesting that the atmospheric patterns over the Arctic and North Atlantic Oceans influence the temperature variations of northern Mongolian Plateau. In addition, we also propose that the warm climate promoted high vegetation productivity and favored the formation of power of the nomadic tribes in the Mongolian Plateau, such as the warm periods 1210s–1250s and 1400s–1430s. Our temperature reconstruction provides us with an opportunity to understand the regional effects of climate warming from multiple perspectives.