bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clusters of lifestyle behaviours and their associations with socio-demographic characteristics in Dutch toddlers
Authors: Krijger Anne , Steenbergen Elly , Schiphof-Godart Lieke , van Rossum Caroline , Verkaik-Kloosterman Janneke , Elstgeest Liset , ter Borg Sovianne , Raat Hein , Joosten Koen 
Published: November 2022

Abstract
Purpose
This study aimed to identify clusters of lifestyle behaviours in toddlers and assess associations with socio-demographic characteristics.

Methods
We used data from the Dutch National Food Consumption Survey 2012–2016 and included 646 children aged 1–3 years. Based on 24-h dietary recalls and a questionnaire, a two-step cluster analysis was conducted to identify clusters in the intake of fruit, vegetables, sugar-sweetened beverages and unhealthy snacks, physical activity and screen time. Logistic regression models assessed associations between socio-demographic characteristics and cluster allocation.

Results
Three clusters emerged from the data. The ‘relatively healthy cluster’ demonstrated a high intake of fruit and vegetables, low sugar-sweetened beverage and unhealthy snack intake and low screen time. The ‘active snacking cluster’ was characterised by high unhealthy snack intake and high physical activity, and the ‘sedentary sweet beverage cluster’ by high intake of sugar-sweetened beverages and high screen time. Children aged 1 year were most likely to be allocated to the ‘relatively healthy cluster’. Compared to children of parents with a high education level, children of parents with a low or middle education level were less likely to be in the ‘relatively healthy cluster’, but more likely to be in the ‘sedentary sweet beverage cluster’.

Conclusion
Clusters of lifestyle behaviours can be distinguished already in children aged 1–3 years. To promote healthy lifestyle behaviour, efforts may focus on maintaining healthy behaviour in 1-year-olds and more on switching towards healthy behaviour in 2- and 3-year-olds.
Research progress of fibroblast growth factor 23 in acute kidney injury
Authors: Zhang Lina , Qin Wei 
Published: November 2022

AbstractFibroblast growth factor 23 (FGF23) is primarily produced in bones and mainly regulates calcium and phosphorus metabolism. The level of circulating FGF23 increases rapidly in the early stage of acute kidney injury (AKI). Recent studies have shown that FGF23 may serve as a biomarker for the diagnosis and poor prognosis of AKI. The mechanism of increased FGF23 in AKI may include increased production of FGF23, decreased renal clearance of FGF23, and some new regulatory factors, such as inflammation and glycerol 3-phosphate. However, the biological effects of elevated FGF23 in AKI are still unclear. It is also not known whether reducing the level of circulating FGF23 could alleviate AKI or its poor prognosis. Here, we review the pathophysiological mechanism and possible regulation of FGF23 in AKI and discuss the possibility of using FGF23 as a therapeutic target.
Recent activity and paleoseismicity of an intraplate extensional fault: the Calamocha fault (Jiloca graben, central Iberian Chain)
Authors: Peiro Alba , Simón José L. , Martín-Bello Leticia , Arlegui Luis E. , Ezquerro Lope , Luzón Aránzazu , Medialdea Alicia , Corral Belén , Liesa Carlos L. 
Published: November 2022

AbstractThe Calamocha fault is an 18-km-long, NNW–SSE striking pure normal fault that moves down the northern sector of the Jiloca graben with respect to the Neogene infill of the Calatayud basin (central Iberian Chain). Its structure and kinematics are characterized by means of detailed geological mapping, morphotectonic analysis and data recording at the outcrop scale. The Calamocha fault represents the inversion of a previous contractional fault zone under the recent tensional stress field (WSW–ENE trendingσ3trajectories). The extensional activity started during the Late Pliocene (ca. 3.8 Ma), accumulating a maximum net slip of 190–230 m (long-term slip rate of 0.05–0.06 mm/a). The palaeoseismological study of three artificial exposures near Calamocha town evidenced recurrent slip during the Late Pleistocene, which proves its active character. Analysis of faulted clastic alluvial units, dated by means of optically stimulated luminescence (OSL), reveals at least eight slip events since 145.9 ± 9.1 ka, the last one being younger than 13.8 ± 0.9 ka. Only a few events represent visible accumulated displacement on the main synthetic rupture surfaces; this allows a rough estimate of the short-term slip rate (during the Late Pleistocene) of about 0.1 mm/a, faster than the long-term rate. The Calamocha fault could potentially produce a characteristic earthquake (in the sense of Schwartz and Coppersmith, J Geophys Res 89:5681–5698, 1984) with moment magnitudeMw≈ 6.7 ± 0.3 (Mw≈ 6.9 ± 0.3 in a scenario of activation of the whole Calamocha–Daroca fault zone), average coseismic displacement of 0.5–1.3 m and average recurrence period under 15 ka.
The effect of tetrastarch on the endothelial glycocalyx layer in early hemorrhagic shock using fluorescence intravital microscopy: a mouse model
Authors: Ando Tadao , Uzawa Kohji , Yoshikawa Takahiro , Mitsuda Shingo , Akimoto Yoshihiro , Yorozu Tomoko , Ushiyama Akira 
Published: November 2022

Abstract
Purpose
To investigate vascular endothelial dysfunction based on glycocalyx impairment in massive hemorrhage and to evaluate fluid therapy.

Methods
In this randomized controlled animal study, we withdrew 1.5 mL blood and administered 1.5 mL resuscitation fluid. Mice were divided into six groups according to the infusion type and administration timing: NS-NS (normal saline), NS-HES ([hydroxyethyl starch]130), HES-NS, NS-ALB (albumin), ALB-NS, and C (control) groups.

Results
The glycocalyx index (GCXI) of a 40-μm artery was significantly larger in group C than in other groups (P < 0.01). Similarly, the GCXI for a 60-μm artery was significantly higher in group C than in NS-NS (P ≤ 0.05), NS-HES (P ≤ 0.01), and NS-ALB groups (P ≤ 0.05). The plasma syndecan-1 concentration, at 7.70 ± 5.71 ng/mL, was significantly lower in group C than in group NS-NS (P ≤ 0.01). The tetramethylrhodamine-labeled dextran (TMR-DEX40) fluorescence intensity in ALB-NS and HES-NS groups and the fluorescein isothiocyanate-labeled hydroxyethyl starch (FITC-HES130) fluorescence intensity in NS-HES and HES-NS groups were not significantly different from those of group C at any time point. FITC-HES130 was localized on the inner vessel wall in groups without HES130 infusion but uniformly distributed in HES130-treated groups in intravital microscopy. FITC-FITC-HES130 was localized remarkably in the inner vessel walls in group HES-NS in electron microscopy.

Conclusions
In an acute massive hemorrhage mouse model, initial fluid resuscitation therapy with saline administration impaired glycocalyx and increased vascular permeability. Prior colloid-fluid administration prevented the progression of glycocalyx damage and improve prognosis. Prior HES130 administration may protect endothelial cell function.
Puppies in the problem-solving paradigm: quick males and social females
Authors: Pinelli Claudia , Scandurra Anna , Di Lucrezia Alfredo , Aria Massimo , Semin Gün R. , D’Aniello Biagio 
Published: November 2022

AbstractWe report an observational, double-blind study that examined puppies’ behaviors while engaged in solving an experimental food retrieval task (food retrieval task instrument: FRTI). The experimental setting included passive social distractors (i.e., the dog’s owner and a stranger). The focus was on how the social and physical environment shapes puppies’ behaviors according to sex. The dependent variables were the number of tasks solved on an apparatus (Performance Index) and the time required to solve the first task (Speed). Sex and Stress were set as explanatory factors, and Social Interest, FRTI interactions, other behavior, and age as covariates. The main findings were that male puppies solved the first task faster than females. On the other hand, females displayed significantly more social interest and did so more rapidly than males. Males showed delayed task resolution. This study demonstrates sex differences in a problem-solving task in dog puppies for the first time, thus highlighting that sexually dimorphic behavioral differences in problem-solving strategies develop early on during ontogenesis.
Cryo-printed microfluidics enable rapid prototyping for optical-cell analysis
Authors: Garmasukis Rokas , Hackl Claudia , Dusny Christian , Elsner Christian , Charvat Ales , Schmid Andreas , Abel Bernd 
Published: November 2022

AbstractThis paper highlights an innovative, low-cost rapid-prototyping method for generating microfluidic chips with extraordinary short fabrication times of only a few minutes. Microchannels and inlet/outlet ports are created by controlled deposition of aqueous microdroplets on a cooled surface resulting in printed ice microstructures, which are in turn coated with a UV-curable acrylic cover layer. Thawing leaves an inverse imprint as a microchannel structure. For an exemplary case, we applied this technology for creating a microfluidic chip for cell-customized optical-cell analysis. The chip design includes containers for cell cultivation and analysis. Container shape, length, position, and angle relative to the main channel were iteratively optimized to cultivate and analyze different cell types. With the chip, we performed physiological analyses of morphologically distinct prokaryotic Corynebacterium glutamicum DM1919, eukaryotic Hansenula polymorpha RB11 MOX-GFP, and phototrophic Synechocystis sp. PCC 6803 cells via quantitative time-lapse fluorescence microscopy. The technology is not limited to rapid prototyping of complex biocompatible microfluidics. Further exploration may include printing with different materials other than water, printing on other substrates in-situ biofunctionalization, the inclusion of electrodes and many other applications.
Temperature, productivity, and heat tolerance: Evidence from Swedish dairy production
Authors: Ahmed Haseeb , Tamminen Lena-Mari , Emanuelson Ulf 
Published: November 2022

AbstractThis study aims to identify the effects of temperature on dairy production and the heat tolerance of different dairy breeds under heat stress. Using farm and animal-level data from 1435 dairy farms throughout Sweden for 4 years (from 2016 to 2019), we find that a 7-day average of daily maximum temperatures above ~ 20 ºC is associated with sharp declines in milk production. We then estimate the farm-level loss in contribution margin for a typical Swedish dairy farm for the year 2018, which consisted of long-lasting heatwaves and extended summer temperatures. We also estimate that, on average, there are no differences in the impact of heatwaves on milk losses for different dairy breeds but that there exists a trade-off between genetic milk production potential and heat tolerance of a dairy cow. The magnitude of this productivity-tolerance trade-off may differ across breeds, suggesting that the high-production potential animals of certain breeds may be less sensitive to heat stress. These findings have important implications in terms of adapting to heat stress, investing in mitigation measures, and development of future breeds that can ameliorate the current trade-off between production capacity of a cow and its heat tolerance.
Regulatory objectives vs fiscal interests: Are German casino locations motivated by beggar-thy-neighbor policy? An empirical analysis
Authors: Haucap Justus , Nedic Radivoje , Şimşek Talha 
Published: November 2022

AbstractIn this paper we provide an empirical analysis of German casino locations. Due to the “mercantilistic background” of casinos, we assume that casinos are more likely to be found at borders and in tourist areas. Even though location decisions have been made in the past, we use cross-sectional data at county level to analyze whether the current locations of casinos are consistent with present-day policy objectives. We discuss whether fiscal incentives and/or regulatory objectives to prevent harmful gambling are relevant for today's locations of German casinos. For our empirical analysis we use location and tourism indicators which are both significant factors for the location of German casinos. We find that the likelihood of a casino location increases if a county is located at a state border. We conjecture that border locations are chosen to share negative externalities of gambling with neighboring states while attracting revenues from out-of-state gamblers. This can be viewed as a type of beggar-thy-neighbor policy, which is inconsistent, however, with the objectives of the State Treaty, which is to provide legal gambling opportunities for the population within the state. For better implementation of the objectives, a more balanced distribution of casinos throughout the urbanized regions in Germany is recommended.
Stratified guarded first-order transition systems
Authors: Müller Christian , Seidl Helmut 
Published: November 2022

AbstractFirst-order transition systems are a convenient formalism to specify parametric systems such as multi-agent workflows or distributed algorithms. In general, any nontrivial question about such systems is undecidable. Here, we present three subclasses of first-order transition systems where every universal invariant can effectively be decided via fixpoint iteration. These subclasses are defined in terms of syntactical restrictions: negation, stratification and guardedness. While guardedness represents a particular pattern how input predicates control existential quantifiers, stratification limits the information flow between predicates. Guardedness implies that the weakest precondition for every universal invariant is again universal, while the remaining sufficient criteria enforce that either the number of occurring negated literals decreases in every iteration, or the number of required instances of input predicates or the number of first-order variables remains bounded. We argue for each of these three cases that termination of the fixpoint iteration can be guaranteed. We apply these results to identify classes of multi-agent systems, when formalized as first-order transition systems, where noninterference in presence of declassification is decidable for coalitions of attackers of bounded size.
The Moral Pitfalls of Cultivated meat: Complementing Utilitarian Perspective with eco-republican Justice Approach
Authors: Moyano-Fernández Cristian 
Published: November 2022

AbstractThe context of accelerated climate change, environmental pollution, ecosystems depletion, loss of biodiversity and growing undernutrition has led human societies to a crossroads where food systems require transformation. New agricultural practices are being advocated in order to achieve food security and face environmental challenges. Cultivated meat has recently been considered one of the most desired alternatives by animal rights advocates because it promises to ensure nutrition for all people while dramatically reducing ecological impacts and animal suffering. It is therefore presented as one of the fairest means of food production for the coming decades, according to utilitarian arguments.However, food security, environmental concerns and animal welfarism guided by a short-term utilitarianism could have techno-optimism bias and could result in some forms of oppression such as anthropocentrism. I argue that there are still deep-rooted moral issues in food systems that are not addressed primarily by lab-grown meat, mainly derived from a loss of sovereignty. Food practices developed in high-tech labs with artificial interventionism constrain the ability of living entities (that are used as food) to flourish on their own terms. This paper aims to explore how sovereignty entitlements for humans and nonhumans are often overlooked by advocates of cultivated meat and the moral challenges it may pose. Accordingly, a more than utilitarian approach framed by ecological and republican justice is proposed here to shed light on some pitfalls of food chains based on cellular agriculture.
Expected Number of Zeros of Random Power Series with Finitely Dependent Gaussian Coefficients
Authors: Noda Kohei , Shirai Tomoyuki 
Published: November 2022

AbstractWe are concerned with zeros of random power series with coefficients being a stationary, centered, complex Gaussian process. We show that the expected number of zeros in every smooth domain in the disk of convergence is less than that of the hyperbolic Gaussian analytic function with i.i.d. coefficients. When coefficients are finitely dependent, i.e., the spectral density is a trigonometric polynomial, we derive precise asymptotics of the expected number of zeros inside the disk of radius r centered at the origin as r tends to the radius of convergence, in the proof of which we clarify that the negative contribution to the number of zeros stems from the zeros of the spectral density.
Anti-tumor antibody isotype response can be modified with locally administered immunoadjuvants
Authors: Walters Adam A. , Ali Abrar , Wang Julie Tzu-Wen , Al-Jamal Khuloud T. 
Published: November 2022

AbstractIn situ vaccination with immunostimulatory compounds is a demonstrated means to treat tumors preclinically. While these therapeutic effects have been attributed to the actions of T cells or innate immune activation, characterisation of the humoral immune response is seldom performed. This study aims to identify whether the injection of immunoadjuvants, Addavax (Adda) and cytosine-phosphorothioate-guanine oligodeoxynucleotide (CpG), intratumorally can influence the antibody response. Specifically, whether intratumoral injection of immunoadjuvants can alter the tumor-specific antibody target, titre and isotype. Following this, the study aimed to investigate whether serum obtained from in situ vaccinated mice could neutralise circulating tumor cells. Serum was obtained from mice bearing B16F10-OVA-Luc-GFP tumors treated with immunoadjuvants. Antibody targets’ titre and isotype were assessed by indirect ELISA. The ability of serum to neutralise circulating cancer cells was evaluated in a B16F10 pseudo-metastatic model. It was observed that tumor-bearing mice mount a specific anti-tumor antibody response. Antibody titre and target were unaffected by in situ vaccination with immunoadjuvants; however, a higher amount of IgG2c was produced in mice receiving Adda plus CpG. Serum from in situ vaccinated mice was unable to neutralise circulating B16F10 cells. Thus, this study has demonstrated that anti-tumor antibody isotype may be modified using in situ vaccination; however, this alone is not sufficient to neutralise circulating cancer cells.
Graphical Abstract
Justice and the Normative Standards of Explainability in Healthcare
Authors: Kempt Hendrik , Freyer Nils , Nagel Saskia K. 
Published: November 2022

AbstractProviding healthcare services frequently involves cognitively demanding tasks, including diagnoses and analyses as well as complex decisions about treatments and therapy. From a global perspective, ethically significant inequalities exist between regions where the expert knowledge required for these tasks is scarce or abundant. One possible strategy to diminish such inequalities and increase healthcare opportunities in expert-scarce settings is to provide healthcare solutions involving digital technologies that do not necessarily require the presence of a human expert, e.g., in the form of artificial intelligent decision-support systems (AI-DSS). Such algorithmic decision-making, however, is mostly developed in resource- and expert-abundant settings to support healthcare experts in their work. As a practical consequence, the normative standards and requirements for such algorithmic decision-making in healthcare require the technology to be at least as explainable as the decisions made by the experts themselves. The goal of providing healthcare in settings where resources and expertise are scarce might come with a normative pull to lower the normative standards of using digital technologies in order to provide at least some healthcare in the first place. We scrutinize this tendency to lower standards in particular settings from a normative perspective, distinguish between different types of absolute and relative, local and global standards of explainability, and conclude by defending an ambitious and practicable standard of local relative explainability.
“Walking on eggshells”: experiences of underrepresented women inmedical
training
Authors: Rezaiefar Parisa , Abou-Hamde Yara , Naz Farah , Alborhamy Yasmine S. , LaDonna Kori A. 
Published: November 2022

Introduction Medicine remains an inequitable profession for women. Challenges are
compounded for underrepresented women in medicine (UWiM), yet the complex features of
underrepresentation and how they influence women’s career paths remain underexplored.
This qualitative study examined the experiences of trainees self-identifying as UWiM,
including how navigating underrepresentation influenced their envisioned career
paths. Methods Ten UWiM family medicine trainees from one Canadian institution
participated in semi-structured group interviews. Thematic analysis of the data was
informed by feminist epistemology and unfolded during an iterative process of data
familiarization, coding, and theme generation. Results Participants identified as
UWiM based on visible and invisible identity markers. All participants experienced
discrimination and “otherness”, but experiences differed based on how identities
intersected. Participants spent considerable energy anticipating discrimination,
navigating otherness, and assuming protective behaviours against real and perceived
threats. Both altruism and a desire for personal safety and inclusion influenced their
envisioned careers serving marginalized populations and mentoring underrepresented
trainees.
Evaluation of the performance of yielding rockbolts during rockbursts using numerical modeling method
Authors: Wang Jun , Apel Derek B. , Xu Huawei , Wei Chong 
Published: November 2022

AbstractThe assessment of yielding rockbolt performance during rockbursts with actual seismic loading is essential for rockburst supporting designs. In this paper, two types of yielding rockbolts (D-bolt and Roofex) and the fully resin-grouted rebar bolt are modeled via the “rockbolt” element in universal distinct element code (UDEC) after an exact calibration procedure. A two-dimensional (2D) model of a deep tunnel is built to fully evaluate the performance (e.g., capacity of energy-absorption and control of rock damage) of yielding and traditional rockbolts based on the simulated rockbursts. The influence of different rockburst magnitudes is also studied. The results suggest that the D-bolt can effectively control and mitigate rockburst damage during a weak rockburst because of its high strength and deformation capacity. The Roofex is too “soft” or “smooth” to limit the movement of ejected rocks and restrain the large deformation, although it has an excellent deformation capacity. The resin-grouted rebar bolt can maintain a high axial force level during rockbursts but is easy to break during dynamic shocks, which fails to control rapid rock bulking or ejection. Three types of rockbolts cannot control the large deformation and mitigate rockburst damage effectively during violent rockbursts. The rockburst damage severity can be significantly reduced by additional support with cable bolts. This study highlights the effectiveness of numerical modeling methods in assessing the complex performance of yielding rockbolts during rockbursts, which can provide some references to improve and optimize the design of rock supporting in burst-prone grounds.