bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficacy of Environics Color Slides in Detecting the Color Deficiency and Healing
Authors: Somanadhapai Sangeeth , Shah Pooja Nirmal , Yepthomi Tokika , Rana Sunita , Matanhelia Manisha 
Published: November 2022

Chromotherapy, also called Color Therapy or Visible Range Radiation Therapy, is a non-pharmacological therapeutic modality that uses various wavelengths of electromagnetic radiation from within the visible spectrum (colors).
Methods & Materials: The study was performed on 65 healthy participants from SGT University, Gurgaon, India. Full, free, and voluntary informed consent was obtained from all subjects and/or their legal guardian(s). Colour deficiency was diagnosed with the help of Environics Colour Slides and an Instrument called Lecher Antenna which works on the principle of resonance. The diagnosis results obtained from color slides and Lecher Antenna, (SBJ International, PARIS) were compared with the results obtained from the Es- Teck Complex, (LD Technology™, US) an FDA-approved Medical Software and Machine.
Results: It was observed that 86.11% of participants showed improvement in their health conditions after using the Environics Colour Slides for the period specified during the diagnosis. It was also observed that there was an 87.69% correlation between the findings of the Environics Colour Slides / Lecher Antenna combination and the ES-Teck Medical Software in identifying the health condition of the participants.
Conclusion: Chromotherapy will greatly benefit from this evidence base and help propagate this alternative treatment modality for the safe, and non-pharmacological treatment of many diseases [5].
Women's reproductive traits and ischemic stroke: a two‐sample Mendelian randomization study
Authors: Wang Zhenqian , Lu Jiawen , Weng Weipin , Zhang Li , Zhang Jie 
Published: November 2022

AbstractObjectiveWe conducted a Mendelian randomization (MR) study to disentangle causal associations between women's reproductive behaviors and ischemic stroke (IS) and investigate the roles of two modifiable risk factors (body mass index (BMI) and educational attainment (EA)) in these associations.MethodsUsing summary‐level data from large‐scale genome‐wide association studies, we performed univariable MR to examine whether there is genetic evidence that women's reproductive traits are causally associated with IS and its subtypes. Multivariable MR and MR mediation analysis were used to investigate whether BMI and EA are common mechanisms or mediators for these associations. A set of sensitivity analyses were conducted to test valid MR assumptions.ResultsWe observed consistent and statistically significant associations across female and sex‐combined analyses for earlier age at first birth (AFB) and age at first sexual intercourse (AFS) with a higher risk of IS and large‐artery atherosclerotic stroke (LAS) risk in the primary analysis. The odds ratios of IS per 1 SD increase in genetically predicted early AFB and AFS were 0.93 (95% CI, 0.86–0.99; p = 0.046) and 0.83 (95% CI, 0.70–0.97, p = 0.020), respectively. Further analyses indicated that BMI played a shared role in AFS and IS/LAS while EA played a shared role in AFS/AFB and IS/LAS as well as a mediator in the path from AFS to IS/LAS.InterpretationThese findings may inform prevention strategies and interventions directed toward relative women's reproductive behaviors and IS. Future studies are warranted to explore other factors related to EA which are responsible for these causalities.
Biomimetic Peridontium Patches for Functional Periodontal Regeneration
Authors: Ma Yue , Yang Xueting , Chen Yan , Zhang Jiumeng , Gai Kuo , Chen Jinlong , Huo Fangjun , Guo Qiang , Guo Weihua , Gou Maling , Yang Bo , Tian Weidong 
Published: November 2022

AbstractThe unique structure of the periodontium, including the alveolar bone, cementum, and periodontal ligament (PDL), presents difficulties for the regeneration of its intricate organization. Irreversible structural breakdown of the periodontium increases the risk of tooth loosening and loss. Although the current therapies can restore the periodontal hard tissues to a certain extent, the PDL with its high directionality of multiple groups with different orientations and functions cannot be reconstructed. Here, biomimetic peridontium patches (BPPs) for functional periodontal regeneration using a microscale continuous digital light projection bioprinting method is reported. Orthotopic transplantation in the mandibles shows effective periodontal reconstruction. The resulting bioengineered tissues closely resembles natural periodontium in terms of the “sandwich structures,” especially the correctly oriented fibers, showing different and specific orientation in different regions of the tooth root, which has never been found in previous studies. Furthermore, after the assessment of clinically functional properties it is found that the regenerative periodontium can achieve stable tooth movement under orthodontic migration force with no adverse consequences. Overall, the BPPs promote reconstruction of the functional periodontium and the complex microstructure of the periodontal tissue, providing a proof of principle for the clinical functional treatment of periodontal defects.
Multiplexed Ultrasensitive Sample‐to‐Answer RT‐LAMP Chip for the Identification of SARS‐CoV‐2 and Influenza Viruses
Authors: Song Minsun , Hong SoonGweon , Lee Luke P. 
Published: November 2022

AbstractPrompt on‐site diagnosis of SARS‐CoV‐2 with other respiratory infections will have minimized the global impact of the COVID‐19 pandemic through rapid, effective management. However, no such multiplex point‐of‐care (POC) chip has satisfied a suitable sensitivity of gold‐standard nucleic acid amplification tests (NAATs). Here, a rapid multiplexed ultrasensitive sample‐to‐answer loop‐mediated isothermal amplification (MUSAL) chip operated by simple LED‐driven photothermal amplification to detect six targets from single‐swab sampling is presented. First, the MUSAL chip allows ultrafast on‐chip sample preparation with ≈500‐fold preconcentration at a rate of 1.2 mL min−1. Second, the chip enables contamination‐free amplification using autonomous target elution into on‐chip reagents by photothermal activation. Finally, the chip accomplishes multiplexed on‐chip diagnostics of SARS‐CoV‐2 and influenza viruses with a limit of detection (LoD) of 0.5 copies µL−1. The rapid, ultrasensitive, cost‐effective sample‐to‐answer chip with a multiplex capability will allow timely management of various pandemics situations that may be faced shortly.
A Gate Programmable van der Waals Metal‐Ferroelectric‐Semiconductor Vertical Heterojunction Memory
Authors: Li Wanying , Guo Yimeng , Luo Zhaoping , Wu Shuhao , Han Bo , Hu Weijin , You Lu , Watanabe Kenji , Taniguchi Takashi , Alava Thomas , Chen Jiezhi , Gao Peng , Li Xiuyan , Wei Zhongming , Wang Lin‐Wang , Liu Yue‐Yang , Zhao Chengxin , Zhan Xuepeng , Han Zheng Vitto , Wang Hanwen 
Published: November 2022

AbstractFerroelectricity, one of the keys to realize non‐volatile memories owing to the remanent electric polarization, is an emerging phenomenon in the 2D limit. Yet the demonstrations of van der Waals (vdW) memories using 2D ferroelectric materials as an ingredient are very limited. Especially, gate‐tunable ferroelectric vdW memristive device, which holds promises in future multi‐bit data storage applications, remains challenging. Here, a gate‐programmable multi‐state memory is shown by vertically assembling graphite, CuInP2S6, and MoS2 layers into a metal(M)‐ferroelectric(FE)‐semiconductor(S) architecture. The resulted devices seamlessly integrate the functionality of both FE‐memristor (with ON–OFF ratios exceeding 105 and long‐term retention) and metal‐oxide‐semiconductor field effect transistor (MOS‐FET). Thus, it yields a prototype of gate tunable giant electroresistance with multi‐levelled ON‐states in the FE‐memristor in the vertical vdW assembly. First‐principles calculations further reveal that such behaviors originate from the specific band alignment between the FE‐S interface. Our findings pave the way for the engineering of ferroelectricity‐mediated memories in future implementations of 2D nanoelectronics.
Stretchable Composite Conductive Fibers for Wearables
Authors: Zhang Yue , Zhang Yufan , Zhou Jiahui , Zhang Desuo , Lin Hong , Chen Yuyue , Li Yi , Xiong Jiaqing 
Published: November 2022

AbstractFibers and textiles are attractive substrates for constructing wearables, the devices rely on conductive fibers with good stretchability to realize electrical conductivity and mechanical adaptivity. The exploitation of stretchable composite conductive fibers (SCCFs) requires diverse strategies in material options and process methods, tackling the challenge in balancing electrical and mechanical properties for ultrafine fiber, which highly determine the properties and applications. In this article, first the working mechanism and advantages of the SCCFs in wearables is introduced. Second, different conductive fillers as well as their respective incorporation strategies and performance superiorities in fabricating SCCFs are systematically summarized. Third, the integration routes of the conductive fillers in SCCFs are indicated and compared, presenting different fabrication strategies and mechanisms for improving the performance of SCCFs. Thereafter, the typical applications of SCCFs in energy management, sensing, actuators, heaters, and displays are highlighted. Accordingly, the main challenges of SCCFs for wearable applications are indicated, and the possible solutions for challenges tackling are proposed. This review prepared aims to highlight the importance of SCCFs in wearables, and provides insights in terms of mechanism, materials, fabrication, and performance improvement, paving a referable way to promote the innovative exploitation and development of SCCFs, extending the application scenarios.
Developing Next‐Generation Protein‐Based Vaccines Using High‐Affinity Glycan Ligand‐Decorated Glyconanoparticles
Authors: Gao Yanan , Wang Wei , Yang Yunru , Zhao Qingyu , Yang Chendong , Jia Xiaoying , Liu Yang , Zhou Minmin , Zeng Weihong , Huang Xuefei , Chiu Sandra , Jin Tengchuan , Wu Xuanjun 
Published: November 2022

AbstractMajor diseases, such as cancer and COVID‐19, are frightening global health problems, and sustained action is necessary to develop vaccines. Here, for the first time, ethoxy acetalated dextran nanoparticles (Ace‐Dex‐NPs) are functionalized with 9‐N‐(4H‐thieno[3,2‐c]chromene‐2‐carbamoyl)‐Siaα2−3Galβ1−4GlcNAc (TCCSia‐LacNAc) targeting macrophages as a universal vaccine design platform. First, azide‐containing oxidized Ace‐Dex‐NPs are synthesized. After the NPs are conjugated with ovalbumin (OVA) and resiquimod (Rd), they are coupled to TCCSia‐LacNAc‐DBCO to produce TCCSia‐Ace‐Dex‐OVA‐Rd, which induce a potent, long‐lasting OVA‐specific cytotoxic T‐lymphocyte (CTL) response and high anti‐OVA IgG, providing mice with superior protection against tumors. Next, this strategy is exploited to develop vaccines against infection by severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2). The receptor‐binding domain (RBD) of the SARS‐CoV‐2 spike protein is the main target for neutralizing antibodies. The TCCSia‐Ace‐Dex platform is preferentially used for designing an RBD‐based vaccine. Strikingly, the synthetic TCCSia‐Ace‐Dex‐RBD‐Rd elicited potent RBD‐neutralizing antibodies against live SARS‐CoV‐2 infected Vero E6 cells. To develop a universal SARS‐CoV‐2 vaccine, the TCCSia‐Ace‐Dex‐N‐Rd vaccine carrying SARS‐CoV‐2 nucleocapsid protein (N) is also prepared, which is highly conserved among SARS‐CoV‐2 and its variants of concern (VOCs), including Omicron (BA.1 to BA.5); this vaccine can trigger strong N‐specific CTL responses against target cells infected with SARS‐CoV‐2 and its VOCs.
Coordinating Anions “to the Rescue” of the Lithium Ion Mobility in Ternary Solid Polymer Electrolytes Plasticized With Ionic Liquids
Authors: Hoffknecht Jan‐Philipp , Wettstein Alina , Atik Jaschar , Krause Christian , Thienenkamp Johannes , Brunklaus Gunther , Winter Martin , Diddens Diddo , Heuer Andreas , Paillard Elie 
Published: November 2022

AbstractLithium salts with low coordinating anions such as bis(trifluoromethanesulfonyl)imide (TFSI) have been the state‐of‐the‐art for polyethylene oxide (PEO)‐based “dry” polymer electrolytes for 3 decades. Plasticizing PEO with TFSI‐based ionic liquids (ILs) to form ternary solid polymer electrolytes (TSPEs) increases conductivity and Li+ diffusivity. However, the Li+ transport mechanism is unaffected compared to their “dry” counterparts and is essentially coupled to the dynamics of the polymer host matrix, which limits Li+ transport improvement. Thus, a paradigm shift is hereby suggested: the utilization of more coordinating anions such as trifluoromethanesulfonyl‐N‐cyanoamide (TFSAM), able to compete with PEO for Li+ solvation, to accelerate the Li+ transport and reach a higher Li+ transference number. The Li–TFSAM interaction in binary and ternary TFSAM‐based electrolytes is probed by experimental methods and discussed in the context of recent computational results. In PEO‐based TSPEs, TFSAM drastically accelerates the Li+ transport (increases Li+ transference number by a factor 6 and the Li+ conductivity by 2–3) and computer simulations reveal that lithium dynamics are effectively re‐coupled from polymer to anion dynamics. Last, this concept of coordinating anions in TSPEs is successfully applied in LFP||Li metal cells leading to enhanced capacity retention (86% after 300 cycles) and an improved rate performance at 2C.
Air Instability of Ni‐Rich Layered Oxides–A Roadblock to Large Scale Application
Authors: Zhang Wujiu , Yuan Chuhan , Zhu Jifu , Jin Ting , Shen Chao , Xie Keyu 
Published: November 2022

AbstractBenefiting from the excellent lithium ions diffusion kinetics and considerable discharge specific capacity, Ni‐rich layered oxides have become the preferred selection cathode active materials (CAMs) for high energy density Li‐ion batteries. However, due to the distinctive electronic structure of nickel ions (Ni2+/3+/4+) and the strict criteria for sintering conditions, the Ni‐rich CAMs inherently suffer from notorious deterioration when in contact with the ambient air. This review provides a comprehensive and critical overview of air instability for Ni‐rich CAMs, a neglected but critical issue for large‐scale application. The fundamental understanding of derivation of air instability and characterizations is first given, followed by a discussion of evolution behaviors and the corresponding negative influence on fabricating properties of electrodes and electrochemical/safety performance of batteries. Afterward, various material modification strategies for improving air storage stability including pre‐treatment by doping and coating and post‐treatment by gas, wash, and heat are overviewed. Finally, some perspectives for further exploration to address the air instability issue and pave ways toward Ni‐rich CAMs’ practical applications are also proposed.
A cross‐sectional analysis of the demand for coffee in the United States
Authors: Capps Oral , Cheng Muxi , Kee Jennifer , Priestley Samuel L. 
Published: November 2022

AbstractThe purposes of this study were to develop a profile of households who purchase coffee, to determine the socioeconomic determinants of the demand for coffee by US households, and to update the own‐price, cross‐price, and income elasticities of demand for US households. The profile suggests to targeting wealthier households, households without children living in the household, older households, white households, and households located in the Pacific region and in New England. The own‐price elasticity of −1.93 indicates that the demand for at‐home purchases of coffee is elastic. Tea is a substitute for coffee. Given the income elasticity of 0.20, changes in household income are not likely to have sizeable impacts on at‐home coffee consumption. Nevertheless, coffee is a necessity in economic parlance. The source of data for this analysis was the NielsenIQ pertaining to 61,380 households for calendar year 2015. [EconLit Citations: D1, D9, D12].
Occupational health surveillance and detection of emerging occupational diseases among Taiwan farmers, through analysis of national‐based farmers' and medico‐administrative databases
Authors: Wang Chung‐Ching , Lin Gwan‐Ling , Lin Yu‐Jen , Chen Wei‐Liang , Wu Wei‐Te 
Published: November 2022

AbstractObjectivesThe purpose of this study was to identify occupational injuries and diseases associated with agriculture in Asia, to provide a reference for prevention and hypotheses for future research.MethodsWe matched data on agricultural workers (n = 963,124) enrolled in Taiwan's national Farmers Health Insurance since its inception in 1989, to general population controls of the same age, gender, and township. The study population was linked to the National Health Insurance Research Database from 2001 to 2016 for inpatient cases. Logistic regression was used to assess odds ratios for outcomes.ResultsFarmers had 2.76 times the risk of mycotic corneal ulcer (95% CI: 1.96–3.87) and 1.65 times the risk of typhus fever infections (95% CI: 1.47–1.85) compared to the general population. The odds ratio for poisonous animal bites was 2.22 (95% CI: 2.07–2.38), for falling into a storm drain or manhole was 2.04 (95% CI: 1.30–3.20), and for toxic effects from pesticides was 2.01 (95% CI: 1.92–2.11). The toxic effects of organophosphate and carbamate insecticides were correlated with the cultivation of rice, fruit trees, and flowers. Q fever and motorcycle accidents were associated with fruit tree cultivation.ConclusionsThe study identifies agricultural occupational injuries and diseases that may inform occupational health policy and the development of prevention priorities to prevent occupational hazards for farmers.
Bioconjugation via Hetero‐Selective Clamping of Two Different Amines withortho‐Phthalaldehyde
Authors: Chu Xin , Li Bo , Liu Hao‐Yang , Sun Xiaowei , Yang Xiaochen , He Gang , Zhou Chuanzheng , Xuan Weimin , Liu Shu‐Lin , Chen Gong 
Published: November 2022

AbstractAmino groups are common in both natural and synthetic compounds and offer a very attractive class of endogenous handles for bioconjugation. However, the ability to differentiate two types of amino groups and join them with high hetero‐selectivity and efficiency in a complex setting remains elusive. Herein, we report a new method for bioconjugation via one‐pot chemoselective clamping of two different amine nucleophiles using a simpleortho‐phthalaldehyde (OPA) reagent. Various α‐amino acids, aryl amines, and secondary amines can be crosslinked to the ϵ‐amino side chain of lysine on peptides or proteins with high efficiency and hetero‐selectivity. This method offers a simple and powerful means to crosslink small molecule drugs, imaging probes, peptides, proteins, carbohydrates, and even virus particles without any pre‐functionalization.
Inlaying Bismuth Nanoparticles on Graphene Nanosheets by Chemical Bond for Ultralong‐Lifespan Aqueous Sodium Storage
Authors: Zhu Haojie , Wang Fangcheng , Peng Lu , Qin Tingting , Kang Feiyu , Yang Cheng 
Published: November 2022

AbstractRechargeable aqueous sodium ion batteries (ASIBs) are rising as an important alternative to lithium ion batteries, owing to their safety and low cost. Metal anodes show a high theoretical capacity and nonselective hydrated ion insertion for ASIBs, yet their large volume expansion and sluggish reaction kinetics resulted in poor electrochemical stability. Herein, we demonstrate an electrode cyclability enhancement mechanism by inlaying bismuth (Bi) nanoparticles on graphene nanosheets through chemical bond, which is achieved by a unique laser induced compounding method. This anchored metal‐graphene heterostructure can effectively mitigate volume variation, and accelerate the kinetic capability as the active Bi can be exposed to the electrolyte. Our method can achieve a reversible capacity of 122 mAh g−1 at a large current density of 4 A g−1 for over 9500 cycles. This finding offers a desirable structural design of other metal anodes for aqueous energy storage systems.
Tuning Mass Transport in Electrocatalysis Down to Sub‐5 nm through Nanoscale Grade Separation
Authors: Liu Zhenhui , Du Yue , Yu Ruohan , Zheng Mingbo , Hu Rui , Wu Jingsong , Xia Yongyao , Zhuang Zechao , Wang Dingsheng 
Published: November 2022

AbstractNano and single‐atom catalysis open new possibilities of producing green hydrogen (H2) by water electrolysis. However, for the hydrogen evolution reaction (HER) which occurs at a characteristic reaction rate proportional to the potential, the fast generation of H2nanobubbles at atomic‐scale interfaces often leads to the blockage of active sites. Herein, a nanoscale grade‐separation strategy is proposed to tackle mass‐transport problem by utilizing ordered three‐dimensional (3d) interconnected sub‐5 nm pores. The results reveal that 3dcriss‐crossing mesopores with grade separation allow efficient diffusion of H2bubbles along the interconnected channels. After the support of ultrafine ruthenium (Ru), the 3dmesopores are on a superior level to two‐dimensional system at maximizing the catalyst performance and the obtained Ru catalyst outperforms most of the other HER catalysts. This work provides a potential route to fine‐tuning few‐nanometer mass transport during water electrolysis.
17O Hyperfine Spectroscopy Reveals Hydration Structure of Nitroxide Radicals in Aqueous Solutions
Authors: Hecker Fabian , Fries Lisa , Hiller Markus , Chiesa Mario , Bennati Marina 
Published: November 2022

AbstractThe hydration structure of nitroxide radicals in aqueous solutions is elucidated by advanced17O hyperfine (hf) spectroscopy with support of quantum chemical calculations and MD simulations. A piperidine and a pyrrolidine‐based nitroxide radical are compared and show clear differences in the preferred directionality of H‐bond formation. We demonstrate that these scenarios are best represented in17O hf spectra, where in‐plane coordination over‐type H‐bonding leads to little spin density transfer on the water oxygen and small hf couplings, whereas‐type perpendicular coordination generates much larger hf couplings. Quantitative analysis of the spectra based on MD simulations and DFT predicted hf parameters is consistent with a distribution of close solvating water molecules, in which directionality is influenced by subtle steric effects of the ring and the methyl group substituents.
Neutralisation der Auswirkungen des Virulenzfaktors LecA aus Pseudomonas aeruginosa auf Humanzellen durch neue glykomimetische Inhibitoren
Authors: Zahorska Eva , Rosato Francesca , Stober Kai , Kuhaudomlarp Sakonwan , Meiers Joscha , Hauck Dirk , Reith Dorina , Gillon Emilie , Rox Katharina , Imberty Anne , Römer Winfried , Titz Alexander 
Published: November 2022

AbstractDie beiden tetravalenten Lektine LecA und LecB des ESKAPE‐Erregers Pseudomonas aeruginosa sind notwendig für dessen bakterielle Adhäsion, Biofilmbildung und Invasion in Wirtszellen. Sie gelten daher als Ansatzpunkte zur medikamentösen antiinfektiösen Therapie. Vor kurzem berichteten wir über hochwirksame divalente Galaktoside als spezifische LecA‐Inhibitoren. Diese litten jedoch unter einer sehr geringen Löslichkeit und einer intrinsischen chemischen Instabilität aufgrund zweier Acylhydrazon‐Motive, was weitere biologische Untersuchungen ausschloss. Hier haben wir jene Acylhydrazone bioisoster ersetzt und systematisch die Identität und Länge des Linkers zwischen den beiden für die LecA‐Bindung erforderlichen Galaktosiden variiert. Die optimierten divalenten LecA‐Liganden waren nun deutlich stabiler und bis zu 1000‐fach löslicher. Dies ermöglichte nun ihre biologische Charakterisierung: Die Leitsubstanz L2 hemmte in vitro die Bindung von LecA an Lungenepithelzellen, stellte den Wundverschluss im Zellkulturmodell wieder her und verringerte die Invasion von P. aeruginosa in Wirtszellen.