bluuebunny/crossref_metadata_2025_split huggingface dataset:
Unraveling Major Proteins of Mycobacterium tuberculosis Envelope
Authors: Bisht Deepa , Singh Rananjay , Sharma Devesh , Sharma Divakar , Gautam Sakshi , Gupta Mahendra Kumar 
Published: September 2022

Abstract:
Although treatable, resistant form of tuberculosis (TB) has posed a major impediment to the
effective TB control programme. As the Mycobacterium tuberculosis cell envelope is closely associated
with its virulence and resistance, it is very important to understand the cell envelope for better
treatment of causative pathogens. Cell membrane plays a crucial role in imparting various cell functions.
Proteins being the functional moiety, it is impossible to characterize the functional properties
based on genetic analysis alone. Proteomic based research has indicated mycobacterial envelope as a
good source of antigens/proteins. Envelope/membrane and associated proteins have an anticipated role
in biological processes, which could be of vital importance to the microbe, and hence could qualify as
drug targets. This review provides an overview of the prominent and biologically important cell envelope
and highlights the different functions offered by the proteins associated with it. Selective targeting
of the mycobacterial envelope offers an untapped opportunity to address the problems associated
with the current drug regimen and also will lead to the development of more potent and safer drugs
against all forms of tuberculous infections.
AChR+ Ocular Myasthenia and Facial Hemispasm: A Case Report of Unusual
Association and Botulinum Toxic Type A Safety and Efficacy
Authors: Zoccolella Stefano , Gigante Angelo Fabio , Misceo Salvatore 
Published: September 2022

Introduction:
Hemifacial spasm represents segmental myoclonus of muscles innervated
by the facial nerve, which is usually and successfully treated with botulinum toxin. Botulinum toxin
(BTX) acts as an acetylcholine release inhibitor at presynaptic cholinergic junctions and therefore
is considered contraindicated (or administrable with caution) in patients with neuromuscular
disorders like Myasthenia Gravis (MG). Moreover, to date, the association of hemifacial spasm and
ocular MG is extremely rare and only a few cases have been described.

Case Presentation:
We report the case of a 73 years old man with a 3-year history of ocular MG
who developed a left hemifacial spasm. The patient underwent hemispasm, treatment with BTX
type A (abobotulinum toxin-A, total dose of 50 IU) that resulted in safe and successful 6 months
re-evaluation.

Conclusion:
Our results suggest that in selected cases with concomitant MG and conditions characterized
by orbicularis oculi spasms or hemispasm, BTX therapy may not be contraindicated and
could be given at longer intervals due to prolonged effects.
Stable Isotopic Analysis of Long-whiskered Catfish (Sperata aor) Otoliths
for Characterization of their Habitat and Relationship with Water Temperature
in the Ganges River
Authors: Ghosh Prosenjit , Nazir Aafaq , Sakthivel Thamizharasan , Khan M. Afzal 
Published: September 2022

Background:
Spatial variability of stable isotope ratios in water from River Ganges is
preserved in aragonite or calcite present in otoliths and formed at equilibrium with ambient water.
This technique is used for a set of long-whiskered catfish aragonite otoliths from four different locations along the course of the River Ganges

Methods:
Acid digestion of otolith and the analysis of δ13C and δ18O in these carbonates using an
isotope ratio mass spectrometer allowed the distinction of fish habitat and provided an idea about
environmental conditions of water along the Ganges River.

Results:
The δ18O signature of otolith carbonate revealed a distinct compositional trend denoting
glacial water input in the upstream segment of the Ganges, close to the water reservoir at Narora.
However, the δ13C values remained constant, suggesting similar bicarbonate composition and food
intake along the stream length. The δ18O signature in otolith from Varanasi was unexpectedly
lighter and showed a tendency of the catfish population to migrate upstream segment of the river.
The fish from the Narora location showed the lowest δ18O values, denoting the signature of water
derived from the melting of a glacier. The heavier δ18O values were seen in the population from Kanpur. The upstream migration of fish population is indicated from the δ18O values of a fish otolith from
Varanasi and Bhagalpur. The Varanasi location shows aberration in δ18O signature in otoliths, and
this exists because this catfish moves to other places to avoid anthropogenic stress at this location

Conclusion:
The δ18O of otolith carbonate covaries with average environmental temperature recorded at the individual location and serves as an important thermometric measurement for marking
environmental conditions and stress in changing climatic parameters along the stream length of
River Ganges and its tributaries.
Heat Treatment of High Manganese Austenitic Steel: Structural and
Mechanical Properties
Authors: Lenda Omar Ben , M’ghari Oumayma , Ibnlfassi Amina , Yassine Youssef Ait , Ahmed Youssef Ait , Saad El Madani 
Published: September 2022

Background:
Technological progress is based on the development of different types of materials.
Among the materials most solicited, we mention metals and alloys. The development of these materials
has been initiated and resulted in a wide range of metallic materials, including austenitic manganese,
constituting, until today, a center of interest for various research works given their wide use in the
industry as well as the recent progress by observation and characterization instruments.

Objective:
The aim of the paper is to investigate the heat treatment conditions of high manganese austenitic
steel and to determine their influence on the structure and mechanical properties.

Methods:
The samples were subjected to an austenitization treatment at five different temperatures: 980
°C, 1000 °C, 1020 °C, 1040 °C, and 1060 °C for 1 hour. The experimental techniques used are hardness,
nanoindentation tests, optical microscopy and X-ray diffraction. Hardness and microhardness
measurements were performed to determine the wear behavior of the studied steels.

Result:
The results indicated that the temperature affects the microstructure; by increasing the austenitizing
temperature with pronounced growth of the austenite as well as the dissolution of carbides M7C3,
the nano hardness and the modulus of elasticity decreases considerably.

Conclusion:
The heat treatment of materials modifying the microstructure is closely related to the mechanical
behavior of the austenitic manganese steel. Therefore, the control of structural changes by heat
treatment is essential to obtain the desired properties. The established heat treatment conditions of the
obtained steel can be suitable for several industrial applications.
Review of Osteoarthritis-related Medicinal Herbs
Authors: Bedse Anjali Prashant , Raut Shilpa Subash , Tambe Varsha Narayan , Zoman Deepali 
Published: September 2022

Abstract:One of the most common causes of joint pain and impairment is osteoarthritis. Osteoarthritis is a condition that affects people all over the world. Osteoarthritis is the second most prevalent and commonly diagnosed rheumatologic disease in India, with a prevalence of 22 to 39 %. Prior to the discovery of extraction and synthetic chemistry, musculoskeletal diseases were treated using medicinal plant compositions. When non-pharmacological therapy is insufficient, a variety of pharmacological therapies can be used to treat arthritis. Synthetic medication therapy, on the other hand, may have undesirable side effects and be expensive. As a result, researchers have been looking at alternative therapies. Herbal drugs have demonstrated the ability to control arthritis in a safe and effective manner. In this review, the safety and efficacy traditionally used plants and main chemical constituents to treat osteoarthritis are reported. After reviewing online databases, we found herbs used to treat osteoarthritis such as Boswellia serrata, Alpinia galanga, Commiphora wightii, Harpagophytum procumbens, Salix alba, Ribes nigrum L., Filipendula ulmaria, Curcuma longa, Zingiber officinale, Capsicum annum, Urtica dioica L., Vitex negundo L., Syzygium aromaticum L. and Allium sativum L. These species are attributed with antioxidant and anti-inflammatory properties, which helped to reduce inflammation and tissue damage. The efficacy and safety of herbal medications for osteoarthritis symptoms are discussed here.
An Integrated Approach to Identify Intrinsically Disordered Regions
in Osteopontin with its Interacting Network in Rheumatoid
Arthritis
Authors: Johri Parul , Singh Sachidanand , Sao Prachi , Banerjee Sudeshna , Trivedi Mala , Singh Aditi , Kostova Irena 
Published: September 2022

Background:
Credentials of molecular diagnostic approaches are an important
goal. Since protein-protein interaction (PPI) network analysis is an apposite method for
molecular valuation, a PPI grid related to Intrinsically Disordered Proteins (IDPs) of RA
was targeted in the present research.

Aim:
The aim of the study is to analyse the role of highly disordered proteins and their
functional parameters in causing Rheumatoid Arthritis (RA).

Method:
Cytoscape software helped in identifying molecular interaction networks. Intrinsically
disordered proteins lack higher order structure and have functional advantages,
but their dysregulation can cause several diseases. All the significant proteins responsible
for RA were identified. On the basis of the data obtained, highly disordered proteins
were selected. Further, MSA was done to find the similarity among the highly disordered
proteins and their functional partners. To determine the most relevant functional partner(
s)/interacting protein(s) out of large network, three filters were introduced in the
methodology.

Result:
The two filtered proteins, IBSP and FGF2, have common functions and also
play a vital role in the pathways of RA. Thus, gives an in-depth knowledge of molecular
mechanisms involved in Rheumatoid Arthritis and targeted therapeutics.

Conclusion:
The network analysis of these proteins has been explored using Cytoscape,
and the proteins with favourable values of graph centrality parameters such as IBSP and
FGF2 are identified. Interesting functional cross talk such as bio mineralization, boneremodelling,
angiogenesis, cell differentiation, etc., of SPP1 with IBSP and FGF2 is
found, which throws light into the fact that these two proteins play a vital role in the
pathways of RA.
Risk Assessment of COVID-19 Cases in Emergency Departments and Clinics With the Use of Real-World Data and Artificial Intelligence: Observational Study
Authors: Logaras Evangelos , Billis Antonis , Kyparissidis Kokkinidis Ilias , Ketseridou Smaranda Nafsika , Fourlis Alexios , Tzotzis Aristotelis , Imprialos Konstantinos , Doumas Michael , Bamidis Panagiotis 
Published: September 2022

Background
The recent COVID-19 pandemic has highlighted the weaknesses of health care systems around the world. In the effort to improve the monitoring of cases admitted to emergency departments, it has become increasingly necessary to adopt new innovative technological solutions in clinical practice. Currently, the continuous monitoring of vital signs is only performed in patients admitted to the intensive care unit.

Objective
The study aimed to develop a smart system that will dynamically prioritize patients through the continuous monitoring of vital signs using a wearable biosensor device and recording of meaningful clinical records and estimate the likelihood of deterioration of each case using artificial intelligence models.

Methods
The data for the study were collected from the emergency department and COVID-19 inpatient unit of the Hippokration General Hospital of Thessaloniki. The study was carried out in the framework of the COVID-X H2020 project, which was funded by the European Union. For the training of the neural network, data collection was performed from COVID-19 cases hospitalized in the respective unit. A wearable biosensor device was placed on the wrist of each patient, which recorded the primary characteristics of the visual signal related to breathing assessment.

Results
A total of 157 adult patients diagnosed with COVID-19 were recruited. Lasso penalty function was used for selecting 18 out of 48 predictors and 2 random forest–based models were implemented for comparison. The high overall performance was maintained, if not improved, by feature selection, with random forest achieving accuracies of 80.9% and 82.1% when trained using all predictors and a subset of them, respectively. Preliminary results, although affected by pandemic limitations and restrictions, were promising regarding breathing pattern recognition.

Conclusions
This study represents a novel approach that involves the use of machine learning methods and Edge artificial intelligence to assist the prioritization and continuous monitoring procedures of patients with COVID-19 in health departments. Although initial results appear to be promising, further studies are required to examine its actual effectiveness.
A Psychosocial Intervention for Supporting Informal Caregivers of Older People With Alzheimer Disease: Protocol for the InnFamiglia Randomized Controlled Trial
Authors: Pasquini Sara , Margaritini Arianna , Gambella Elena , Di Rosa Mirko , Maranesi Elvira , Bevilacqua Roberta , Civerchia Patrizia , Pelliccioni Giuseppe 
Published: September 2022

Background
Dementia is a neurodegenerative syndrome characterized by impaired cognitive functions associated with psychological and behavioral disorders. The informal caregiver has a central role in the life of the person with dementia. Committing a large part of the day to caring for the assisted person inevitably has an effect on the caregiver’s life.

Objective
The aim of this study is to analyze the impact of a psychosocial intervention dedicated to a group of informal caregivers of patients with Alzheimer disease. The intervention will be guided by a trained psychologist who will facilitate the participants’ expression of their emotional states, as compared to a traditional self-help group.

Methods
The intervention described in this paper was designed and developed for the project INNovazione sociale e tecnologica per le FAMIGLIE che assistono malati affetti da Alzheimer (InnFamiglia). The study is designed as a randomized controlled trial (RCT). The RCT includes an experimental group, in which the participants will undertake the psychosocial intervention, and a control group, where participants will receive support according to traditional self-help methodology. Interventions for both groups will last 4 months and will be comprised of 16 sessions.

Results
Participant recruitment, enrollment, and data collection began in 2021. Enrollment continued until September 2022, at which time the last group began the intervention. Data collection will be completed by December 2022, and data analysis will be completed by March 2023. The study findings will be published in peer-reviewed scientific journals and will be presented at scientific meetings. Summaries of the results will also be made available to investigators for dissemination within their clinics.

Conclusions
We hypothesize that the experimental group will be more effective in managing caregiver burden and coping strategies and that this will improve the perception of well-being, anxiety, and depression among caregivers. Our study aims to compare two groups receiving different interventions: a self-help group and a psychosocial group with elements of emotional support. This study may also give us more information about the most appropriate ways to support and help caregivers of people with dementia.

International Registered Report Identifier (IRRID)
DERR1-10.2196/37496
Mental Illness Concordance Between Hospital Clinical Records and Mentions in Domestic Violence Police Narratives: Data Linkage Study
Authors: Karystianis George , Cabral Rina Carines , Adily Armita , Lukmanjaya Wilson , Schofield Peter , Buchan Iain , Nenadic Goran , Butler Tony 
Published: September 2022

Background
To better understand domestic violence, data sources from multiple sectors such as police, justice, health, and welfare are needed. Linking police data to data collections from other agencies could provide unique insights and promote an all-of-government response to domestic violence. The New South Wales Police Force attends domestic violence events and records information in the form of both structured data and a free-text narrative, with the latter shown to be a rich source of information on the mental health status of persons of interest (POIs) and victims, abuse types, and sustained injuries.

Objective
This study aims to examine the concordance (ie, matching) between mental illness mentions extracted from the police’s event narratives and mental health diagnoses from hospital and emergency department records.

Methods
We applied a rule-based text mining method on 416,441 domestic violence police event narratives between December 2005 and January 2016 to identify mental illness mentions for POIs and victims. Using different window periods (1, 3, 6, and 12 months) before and after a domestic violence event, we linked the extracted mental illness mentions of victims and POIs to clinical records from the Emergency Department Data Collection and the Admitted Patient Data Collection in New South Wales, Australia using a unique identifier for each individual in the same cohort.

Results
Using a 2-year window period (ie, 12 months before and after the domestic violence event), less than 1% (3020/416,441, 0.73%) of events had a mental illness mention and also a corresponding hospital record. About 16% of domestic violence events for both POIs (382/2395, 15.95%) and victims (101/631, 16.01%) had an agreement between hospital records and police narrative mentions of mental illness. A total of 51,025/416,441 (12.25%) events for POIs and 14,802/416,441 (3.55%) events for victims had mental illness mentions in their narratives but no hospital record. Only 841 events for POIs and 919 events for victims had a documented hospital record within 48 hours of the domestic violence event.

Conclusions
Our findings suggest that current surveillance systems used to report on domestic violence may be enhanced by accessing rich information (ie, mental illness) contained in police text narratives, made available for both POIs and victims through the application of text mining. Additional insights can be gained by linkage to other health and welfare data collections.
Contribution of Remote Sensing for the Mapping of the Yaoundé Metadiorites
Authors: Metang Victor , Brigitte Domkam , Myrianne Toussi Tawo , Cédrik Tchinda Tsoptie , Steve Wandji-Bamou Franck , Dior Mboutchouang Christelle , Appolinaire Kenzo Henri 
Published: September 2022

Geologists face a number of problems, mainly related to the difficulty of covering the entire terrain, leading to various pieces of information collected and its extrapolation for drawing maps. To overcome these problems, we have proposed to use remote sensing which is a current tool for rock mapping. Remote sensing is a modern tool to highlight several information that conventional mapping methods do not allow. Thus, the objective of this work is to update the geological contours of the Yaoundé metadiorites by processing satellite images coupled with the classical approach. Sentinel 1-A radar images were used. A textural analysis of these images was carried out using the GLCM (Grey Level Co-occurrence Matrix) method, resulting in eight co-occurrence indices, among which three were chosen to perform colored compositions. The colored compositions obtained are VMH and HMV. And the contrasts obtained were compared with maps from previous work and also with field work. The metasedimentary rocks (kyanite - garnet migmatites and garnet micaschists) and metaigneous rocks (metadiorite) constitute the metamorphic complex distinctly mapped by exploiting remote sensing data, superposition maps from previous work and integrating the new sampling points. Remote sensing in geological mapping thus plays an important role mainly in the urbanized study area as it detects the metadiorites under the metasediments despite the existence of anthropogenic works and low vegetation cover.
Технология индивидуально-организационного сопровождения соискателя ученой степени кандидата наук и соискателя ученой степени доктора наук в условиях университета педагогического профиля
Authors: Игнатьева Галина , Самерханова Эльвира 
Published: September 2022

Информационно – ресурсный пакет составлен Игнатьевой Г.А., председателем диссертационного совета 33.2.014.02. ФГБОУ ВО «Нижегородский государственный педагогический университет имени Козьма Минина» по направлению 5.8.7. – Методология и технология профессиональной деятельности (педагогические науки), доктором педагогических наук, профессором; Самерхановой Э.К., первым проректором ФГБОУ ВО «Нижегородский государственный педагогический университет имени Козьма Минина», доктором педагогических наук, профессором.
Информационно – ресурсный пакет является ориентировочной основой деятельности диссертационного совета как пространства подготовки и государственной аттестации научных и научно-педагогических работников высшей квалификации по направлению 5.8.7. – Методология и технология профессиональной деятельности и представляет собой организационно – методическую рамку технологии индивидуально-организационного сопровождения соискателей ученых степеней кандидата наук и доктора наук в условиях университета педагогического профиля.
В работе раскрыта методология индивидуально - организационного сопровождения персонализированной научной деятельности соискателей ученых степеней кандидата или доктора педагогических наук, представлена модель научно-методологического позиционирования диссертационного совета в разноплановом пространстве подготовки и государственной аттестации научных и научно-педагогических работников высшей квалификации по направлению 5.8.7. – Методология и технология профессиональной деятельности, основанная на процессном подходе к организации управления научно-исследовательской работы в университете педагогического профиля; обозначены примерные содержательные тематизмы научно-педагогических исследований в рамках паспорта научной специальности 5.8.7. -Методология и технология профессионального образования (педагогические науки).