bluuebunny/crossref_metadata_2025_split huggingface dataset:
Perioperative Anxiety Associated With Mohs Micrographic Surgery: A Survey-Based Study
Authors: Long Jun , Rajabi-Estarabadi Ali , Levin Adam , Nami Navid , Nouri Keyvan 
Published: April 2022

BACKGROUND
Mohs micrographic surgery (MMS)-associated anxiety is an important issue that remains poorly discussed. Identifying risk factors for MMS-associated anxiety will better equip physicians to manage patients' preoperative anxiety and result in improved patient satisfaction and outcomes.

OBJECTIVE
This study aims in identification of risk factors that may play a role in MMS-associated anxiety among patients with nonmelanoma skin cancer.

METHODS
A cross-sectional case series was conducted among MMS patients collect information on patient demographics and surgical locations and to measure perioperative anxiety and quality of life (QoL). In addition, adjusted linear and logistic regression analyses were performed to identify potential risk factors that predict MMS-associated anxiety.

RESULTS
Significant increases in perioperative anxiety were associated with the eyelid area compared with the noneyelid facial area and nonfacial area (p ≤ .05). Patients with graduate degrees exhibited less anxiety compared with ones who received less education (p ≤ .05). Higher perioperative anxiety was associated with a greater impact on QoL (p ≤ .05).

CONCLUSION
This study identified that surgical location and the patient's educational level are 2 critical predicting factors for perioperative anxiety. Furthermore, perioperative anxiety could negatively affect a patient's quality of life and warrants further investigation into effective management.
Prenatal Antidepressant Exposure and the Risk of Attention-deficit/Hyperactivity Disorder in Childhood: A Cohort Study With Triangulation
Authors: Esen Buket Öztürk , Ehrenstein Vera , Sørensen Henrik Toft , Laugesen Kristina , Pedersen Lars 
Published: April 2022

Background:
Uncontrolled confounding from maternal depression and genetic and environmental factors is expected in studies investigating the effect of prenatal antidepressant exposure on the risk of attention-deficit/hyperactivity disorder (ADHD) in childhood and may explain inconsistencies in the existing evidence. We aimed to assess this effect using triangulation.

Methods:
Using population-based health registries, we conducted a nationwide cohort study of all children born in Denmark between 1997 and 2017 and followed through 2018 for ADHD. We assessed the effect of prenatal antidepressant exposure on the risk of ADHD in childhood by comparing children with and without prenatal antidepressant exposure in terms of adjusted incidence rate ratios (IRRs), adjusted incidence rate differences (IRDs), and adjusted risk differences (RDs) and the associated 95% confidence intervals (CIs). We triangulated results from four different analytic approaches: an overall analysis, a negative control analysis, a sibling analysis, and a former-user analysis.

Results:
The overall study cohort consisted of 1,253,362 children, among whom 28,910 (2.3%) had prenatal antidepressant exposure. ADHD during follow-up was diagnosed among 1,411 (4.9%) of the exposed and in 37,196 (3.0%) of the unexposed children. Triangulation suggested an IRR of 1.09–1.15; an IRD less than 1 case/1,000 person-years, and an RD of 0.9%–2.2% over an up to 18-year period.

Conclusions:
Based on triangulation, we estimated a modest effect of prenatal antidepressant exposure on the risk of ADHD in childhood. However, considering the limitations of our approaches, this observed association may be partially due to residual biases. See video abstract at, http://links.lww.com/EDE/B935.
Exploring Moral Categorizations and Symbolic Boundaries Around People Living With HIV in a Correctional Setting
Authors: Wadams Morgan Lee 
Published: April 2022

ABSTRACT
For people living with HIV, correctional facilities, such as jails, prisons, and remand centers in Canada are complex environments at the intersection of health, justice, social, and criminal systems. Turning toward experiences, I explore my stories and observations of working with people living with HIV as a registered nurse in a large correctional facility in Western Canada. Based upon a narrative understanding of experience, I inquire into these stories and observations through the application of Mary Douglas’ theoretical work on purity versus impurity and Michèle Lamont’s symbolic boundary work. I engage in a reflective dialogue with the newfound meanings and understandings produced and discuss significant personal, practice-based, social, and policy-based insights within the context of my nurse researcher-practitioner role. This dialogue draws attention and raises questions about social practices, HIV-related stigma, correctional nursing, and the particularities of life evident within correctional facilities. Clinical implications for correctional nurses are discussed.
Aerobic exercise training improves nocturnal blood pressure dipping in medicated hypertensive individuals
Authors: Ramirez-Jimenez Miguel , Morales-Palomo Felix , Moreno-Cabañas Alfonso , Alvarez-Jimenez Laura , Ortega Juan F. , Mora-Rodriguez Ricardo 
Published: April 2022

Objective
The absence of nocturnal blood pressure (BP) reduction at night in hypertensive individuals is associated with an increased cardiovascular risk. The main purpose of the present study was to investigate the effects of an aerobic training intervention on nocturnal BP dipping in medicated hypertensive individuals.

Methods
At baseline, hypertensive individuals under pharmacological treatment underwent 24-h ambulatory BP monitoring and a morning urine sample to analyze albumin creatinine ratio (UACR). Then, participants were divided into nocturnal dippers (N = 15; 59 ± 6 years) and nondippers (N = 20; 58 ± 5 years) according to a day-to-night BP reduction of >10% or <10%, respectively. Next, participants underwent a 3-weekly, 4-month aerobic interval training intervention.

Results
Follow-up measurements revealed a reduction in daytime diastolic BP in dippers and nondippers (P
time < 0.001), whereas nighttime systolic BP was reduced only in nondippers (P = 0.004). Regarding dipping pattern, nocturnal systolic BP dipping increased after training in nondippers (5 ± 3 to 9 ± 7%; P = 0.018), whereas in dippers, there was a decrease in nocturnal dipping after training (14 ± 4 to 10 ± 7%, P = 0.016). Nocturnal diastolic BP dipping did not change in nondippers (8 ± 5 to 10 ± 7%; P = 0.273) but decreased in dippers (17 ± 6 to 12 ± 8%; P = 0.004). In addition, UACR was significantly reduced in both groups after training (P
time = 0.020).

Conclusion
Aerobic exercise training is associated with nocturnal BP dipping as nighttime BP was lower than before the program in medicated hypertensive individuals with an initial nondipping phenotype. The lack of improvement in individuals with a dipping phenotype warrants further investigation to discern whether dipping phenotypes influence BP responses to exercise training.
Biodistribution of 89Zr-oxine-labeled human bone marrow-derived mesenchymal stem cells by micro-PET/computed tomography imaging in Sprague–Dawley rats
Authors: Wang Shuzhe , Wang Yan , Qin Tian , Lv Yupeng , Yan Heng , Shao Yifei , Fang Yangyang , Zheng Shaoqiu , Xu Bohua , Qiu Yunliang 
Published: April 2022

Purpose
To develop a method for labeling human bone marrow mesenchymal stem cells (hMSCs) with 89Zr-oxine to characterize the biodistribution characteristics of hMSCs in normal Sprague–Dawley (SD) rats in real-time by micro-PET–computed tomography (micro-PET/CT) imaging.

Methods

89Zr-oxine complex was synthesized from 89Zr-oxalate and 8-hydroxyquinoline (oxine). After hMSCs were labeled with the 89Zr-oxine complex, the radioactivity retention, viability, proliferation, apoptosis, differentiation, morphology, and phenotype of labeled cells were assessed. The biodistribution of 89Zr-oxine-labeled hMSCs in SD rats was tracked in real-time by micro-PET/CT imaging.

Results
The cell labeling efficiency was 52.6 ± 0.01%, and stably retained in cells (66.7 ± 0.9% retention on 7 days after labeling). Compared with the unlabeled hMSCs, 89Zr-oxine labeling did not affect the biological characteristics of cells. Following intravenous administration in SD rats, labeled hMSCs mainly accumulated in the liver (7.35 ± 1.41% ID/g 10 days after labeling, n = 6) and spleen (8.48 ± 1.20% ID/g 10 days after labeling, n = 6), whereas intravenously injected 89Zr-oxalate mainly accumulated in the bone (4.47 ± 0.35% ID/g 10 days after labeling, n = 3).

Conclusion

89Zr-oxine labeling and micro-PET/CT imaging provide a useful and non-invasive method of assessing the biodistribution of cell therapy products in SD rats. The platform provides a foundation for us to further understand the mechanism of action and migration dynamics of cell therapy products.
Factors Affecting the Health-Related Quality of Life of Cancer Survivors According to Metabolic Syndrome
Authors: Lee HyunHae , Kim Ji-Su 
Published: April 2022

Background
Cancer survivors face an increased risk of non–cancer-related deaths, particularly associated with metabolic syndrome. With increased cancer survivors having metabolic syndrome, health-related quality of life beyond cancer diagnosis and treatment has assumed greater importance.

Objective
This study evaluated the prevalence rate of metabolic syndrome in cancer survivors. It examined the correlation between health-related quality of life and influencing factors according to the prevalence of metabolic syndrome.

Methods
This is a cross-sectional national study using secondary data from the 2010-2018 Korean National Health and Nutrition Examination Survey by the Korea Disease Control and Prevention Agency. We analyzed a final sample of 1293 cancer survivors using multiple regression.

Results
The prevalence rate of metabolic syndrome in cancer survivors was measured at 32.1%. Cancer survivors with metabolic syndrome had a lower health-related quality of life than those without it. The difference was statistically significant. Compared with cancer survivors without metabolic syndrome, those with it experienced substantial negative effects from stress, reducing health-related quality of life. Walking and muscle-building workouts had a positive effect on stress and improved quality of life.

Conclusions
Cancer survivors’ metabolic syndrome should be monitored closely. Development of a customized intervention program including stress management and physical activities improves their health-related quality of life.

Implications for Practice
Stress management and physical activities increase health-related quality of life among cancer survivors with metabolic syndrome; thus, healthcare providers should implement intervention programs that promote exercise engagement and stress management for this population.
Myocardial Tissue Oxygenation and Microvascular Blood Volume Measurement Using a Contrast Blood Oxygenation Level–Dependent Imaging Model
Authors: Dendy Jeffrey M. , Hughes Sean G. , Soslow Jonathan H. , Clark Daniel E. , Paschal Cynthia B. , Gore John C. 
Published: April 2022

Objectives
We propose a method of quantitatively measuring drug-induced microvascular volume changes, as well as drug-induced changes in blood oxygenation using calibrated blood oxygen level–dependent magnetic resonance imaging (MRI). We postulate that for MRI signals there is a contribution to R2* relaxation rates from static susceptibility effects of the intravascular blood that scales with the blood volume/magnetic field and depends on the oxygenation state of the blood. These may be compared with the effects of an intravascular contrast agent. With 4 R2* measurements, microvascular blood volume (MBV) and tissue oxygenation changes can be quantified with the administration of a vasoactive drug.

Materials and Methods
The protocol examined 12 healthy rats in a prospective observational study. R2* maps were acquired with and without infusion of adenosine, which increases microvascular blood flow, or dobutamine, which increases myocardial oxygen consumption. In addition, R2* maps were acquired after the intravenous administration of a monocrystalline iron oxide nanoparticle, with and without adenosine or dobutamine.

Results
Total microvascular volume was shown to increase by 10.8% with adenosine and by 25.6% with dobutamine (P < 0.05). When comparing endocardium versus epicardium, both adenosine and dobutamine demonstrated significant differences between endocardial and epicardial MBV changes (P < 0.05). Total myocardial oxygenation saturation increased by 6.59% with adenosine and by 1.64% with dobutamine (P = 0.27). The difference between epicardial and endocardial oxygenation changes were significant with each drug (adenosine P < 0.05, dobutamine P < 0.05).

Conclusions
Our results demonstrate the ability to quantify microvascular volume and oxygenation changes using calibrated blood oxygen level–dependent MRI, and we demonstrate different responses of adenosine and dobutamine. This method has clinical potential in examining microvascular disease in various disease states without the administration of radiopharmaceuticals or gadolinium-based contrast agents.
Evaluation of Virtual Grid Processed Clinical Chest Radiographs
Authors: Gossye Tim , Buytaert Dimitri , Smeets Peter V. , Morbée Lieve , De Wilde Charlotte , Vermeiren Karen , Achten Eric , Bacher Klaus 
Published: April 2022

Objectives
We evaluated the different Virtual Grid software ratios (Fujifilm, Tokyo, Japan) on gridless clinical chest radiographs with visual grading analysis (VGA). In addition, we investigated the 2 image quality assessment algorithms (IQAAs).

Materials and Methods
Gridless chest radiographs of 50 different intensive care unit patients were collected and afterward processed with Virtual Grid software. Different software (SW) grid ratios—6:1, 10:1, 13:1, 17:1, and 20:1—were applied to investigate the image quality (IQ) improvement. Image quality improvement was assessed by 4 radiologists in a relative VGA study where the reference image was processed with SW grid ratio of 10:1. One of the IQAAs used to analyze the radiographs was implemented in our department but was originally developed by the research group of the Duke University Medical Center. A general IQ score (IQS) was calculated based on contrast, detail, and noise. Another IQAA—NIQE (naturalness image quality evaluator)—available in Matlab (MATLAB Research R2019b; the MathWorks, Inc) was evaluated. Both methods were compared with VGA.

Results
Visual grading analysis scores of gridless radiographs are significantly lower (P < 0.001). Image quality increases with increasing SW grid ratios, up to grid ratio of 17:1. However, some anatomical structures—spine and ribs—are negatively affected by the higher grid ratios. A correlation coefficient of 0.99 between the VGA and the IQS was observed. The correlation coefficient between VGA and NIQE was 1.00.

Conclusions
Virtual Grid with SW grid ratio of 6:1 improves the IQ of gridless chest bedside radiographs. The grid ratios 17:1 and 20:1 should be considered carefully as the SW negatively affects parts of the ribs and spine. Therefore, grid ratios up to 13:1 can be advised. The IQAAs are promising and could be used to detect differences in IQ when different scatter correction SW settings are used.
Solitary Chest Wall Tuberculosis Mimicking a Malignancy Demonstrated on FDG PET/CT
Authors: Xiao Liu , Li Yuhao , Li Lin 
Published: April 2022

Abstract
Solitary chest wall tuberculosis is rare. Herein, we reported a case of image findings of chest wall tuberculosis in a 44-year-old woman. On FDG PET/CT, it presented as a solitary soft tissue mass with invasion of adjacent rib, diaphragm, and avid FDG uptake with an SUVmax of 10.19, mimicking a malignancy. The postoperative pathology supported a diagnosis of tuberculosis infection.
International Virtual Simulation Education in Critical Care During COVID-19 Pandemic: Preliminary Description of the Virtual Checklist for Early Recognition and Treatment of Acute Illness and iNjury Program
Authors: Flurin Laure , Tekin Aysun , Bogojevic Marija , Zec Simon , Sun Yuqiang , Li Heyi , Finch Alexander , Ahmad Sumera , Kashyap Rahul , Gajic Ognjen , Niven Alexander S. , Dong Yue 
Published: April 2022

Summary Statement
The Checklist for Early Recognition and Treatment of Acute Illness and iNjury program is a well-established, interactive, and simulation-based program designed to improve the quality of care delivered in intensive care units. The COVID-19 pandemic created an overwhelming surge of critically ill patients worldwide, and infection control concerns limited healthcare providers' access to in-person and hands-on simulation training when they needed it the most. Virtual simulation offers an alternative to in-person training but is often complex and expensive. We describe our successful development and initial implementation of an inexpensive, simulation-based virtual Checklist for Early Recognition and Treatment of Acute Illness and iNjury program to address the pressing need for effective critical care training in various resource-limited settings both within and outside of the United States. The overall satisfaction rate (“excellent” or “very good” responses) was 94.4% after the virtual simulation workshop. Our initial experience suggests that virtual interactions can be engaging and build strong relationships, like in-person continuing professional education, even using relatively simple technology. This knowledge-to-practice improvement platform can be readily adapted to other disciplines beyond critical care medicine.
Interdisciplinary Protocol for the Management of Vision-Threatening Papilledema
Authors: Brady Taylor , Vegunta Sravanthi , Crum Alison V. , Marx Douglas , Patel Bhupendra C. K. , Seay Meagan D. , Schmidt Richard H. , Warner Judith E. A. , Digre Kathleen B. , Katz Bradley J. 
Published: April 2022

Background:
This study evaluates the effectiveness of a multidisciplinary protocol for management of patients with papilledema and vision loss secondary to increased intracranial pressure.

Methods:
Retrospective record review of all adult patients who presented with vision-threatening papilledema (VTPE) and were treated under this protocol. Patients are admitted for lumbar drain placement and diuretics and followed daily to determine if they may be managed medically or require surgery (optic nerve sheath fenestration [ONSF] and/or cerebrospinal fluid [CSF] shunting).

Results:
Nineteen patients were included. Twelve had body mass index in the obese range and 6 were morbidly obese. Fourteen had idiopathic intracranial hypertension. Five had secondary pseudotumor cerebri syndrome related to medication use, dural venous sinus thrombosis, hypothyroidism, end-stage renal disease, pulmonary disease, and diastolic heart failure. Three patients did not require surgery and were discharged on oral diuretics; 3 patients underwent unilateral ONSF, 9 underwent bilateral ONSF, and 4 underwent bilateral ONSF followed by ventriculoperitoneal shunt placement. The average follow-up was 10.1 months. The visual acuity improved bilaterally in 12 patients and unilaterally in 4 patients. The remaining 3 patients had worsened vision in both eyes. Fifteen patients had bilateral improvement in their visual fields. Five eyes in 3 patients showed further constriction of the visual field at follow-up.

Conclusions:
We demonstrate how a multidisciplinary complex care protocol for treating VTPE can expedite and streamline treatment and restore vision. We found that most patients had improved symptoms and signs, including visual acuity, visual fields, and papilledema. We encourage institutions that manage VTPE to adopt similar institutional protocols.
Examining the experiences of Indigenous families seeking health information for their sick or injured child: a scoping review protocol
Authors: Knisley Lisa , Linton Janice , Driedger S. Michelle , Hartling Lisa , Scott Shannon D. 
Published: April 2022

AbstractIntroductionThe Truth and Reconciliation Commission drew attention to the inequalities and systemic harms experienced by Indigenous peoples in Canada and called on the Canadian government and healthcare professionals to close the gap related to Indigenous communities’ access to appropriate healthcare services. The Manitoba Métis Federation (self-governing organization representing Red River Métis) identified a need for Red River Métis families to have meaningful resources when seeking emergency care for their children. A better understanding of Métis families’ experiences in seeking child health information is needed to develop culturally relevant pediatric resources. To date, the literature on Indigenous families’ experiences seeking child health information has not been synthesized. A scoping review will map the literature on Indigenous families’ experiences seeking health information to care for a sick or injured child; and identify the barriers and facilitators to accessing this information.Methods and analysisJoanna Briggs Institute methodology was used to develop the research question, What is the extent and nature of the literature available on the experiences of Indigenous families seeking health information for their sick or injured child? The search strategy, developed with a research librarian with extensive experience in Indigenous Peoples’ health, includes searching MEDLINE, EMBASE PsycINFO, CINAHL, and Scopus databases; grey literature, by searching the internet and consulting reference lists of key publications; examining key Indigenous research journal articles not indexed in the major biomedical databases; and snowball sampling. Two independent reviewers will screen titles and abstracts against the inclusion criteria, then screen the full texts of selected citations. Data will be extracted, collated and charted to summarize the types of studies, healthcare contexts, health information accessed, how health information was accessed, barriers and facilitators to accessing information and related measures.Ethics and DisseminationA consultation exercise with a community advisory committee will review results and inform future research. Results will be integrated with findings from other project stages to inform the adaptation of a child health resource for Red River Métis families.
Co-production of post-diagnostic psychosocial intervention with carers of people with intellectual disability and dementia
Authors: Acton Daniel , Duncan Caroline , Jaydeokar Sujeet 
Published: April 2022

Purpose
This paper aims to underline the importance of using a collaborative approach when designing and adapting a post diagnostic psychosocial intervention of cognitive stimulation therapy (CST) for people with intellectual disability and dementia.

Design/methodology/approach
As part of a service improvement, a manual of CST was adapted, for delivery in clinical practice. A qualitative co-production method allowed participants with a lived experience to provide regular feedback relating to the development of the adapted CST manual and intervention programme. This feedback was used to make continual development changes to the CST manual.

Findings
The study demonstrated co-production with those who provide care is valuable in adapting psychosocial therapies for people with an intellectual disability and dementia. Additional findings identified the need for carer education in ageing, dementia care and the physical health needs for older people with intellectual disability.

Originality/value
To the best of the authors’ knowledge, this is the first study that has used a co-production approach with families and carers in adapting a group therapy programme for people with an intellectual disability. This paper underlines the need for post diagnostic clinical interventions for people with dementia and those who provide care.