bluuebunny/crossref_metadata_2025_split huggingface dataset:
On the determination of thermal boundary conditions for parameter identifications of thermo‐mechanically coupled material models
Authors: Rose Lars , Menzel Andreas 
Published: May 2022

AbstractIdentifiability and sensitivity of thermal boundary coefficients identified alongside thermal material parameters by means of full field measurements during a simple tension test are shown empirically using a simple tension test with self heating as a proof of concept. The identification is started for 10 different initial guesses, all of which converge toward the same optimum. The solution appears to be locally unique and parameters therefore independent, but a comparison against a reference solution indicates high correlation between three model parameters and the prescribed external temperatures required to model heat exchange with either air or clamping jaws. This sensitivity is further analyzed by rerunning the identification with different prescribed external temperatures and by comparing the obtained optimal parameter values. Although the model parameters are independent, optimal values for heat conduction and the heat transfer coefficients are highly correlated as well as sensitive with respect to a change, respectively, measurement error of the external temperatures. A precise fit on the basis of a simple tension test therefore requires precise measurements and a suitable material model which is able to accurately predict dissipated energy.
Abnormal interhemispheric and intrahemispheric functional connectivity dynamics in drug‐naïve first‐episode schizophrenia patients with auditory verbal hallucinations
Authors: Wei Yarui , Han Shaoqiang , Chen Jingli , Wang Caihong , Wang Weijian , Li Hong , Song Xueqin , Xue Kangkang , Zhang Yong , Cheng Jingliang 
Published: May 2022

AbstractNumerous studies indicate altered static local and long‐range functional connectivity of multiple brain regions in schizophrenia patients with auditory verbal hallucinations (AVHs). However, the temporal dynamics of interhemispheric and intrahemispheric functional connectivity patterns remain unknown in schizophrenia patients with AVHs. We analyzed resting‐state functional magnetic resonance imaging data for drug‐naïve first‐episode schizophrenia patients, 50 with AVHs and 50 without AVH (NAVH), and 50 age‐ and sex‐matched healthy controls. Whole‐brain functional connectivity was decomposed into ipsilateral and contralateral parts, and sliding‐window analysis was used to calculate voxel‐wise interhemispheric and intrahemispheric dynamic functional connectivity density (dFCD). Finally, the correlation analysis was performed between abnormal dFCD variance and clinical measures in the AVH and NAVH groups. Compared with the NAVH group and healthy controls, the AVH group showed weaker interhemispheric dFCD variability in the left middle temporal gyrus (p < .01; p < .001), as well as stronger interhemispheric dFCD variability in the right thalamus (p < .001; p < .001) and right inferior temporal gyrus (p < .01; p < .001) and stronger intrahemispheric dFCD variability in the left inferior frontal gyrus (p < .001; p < .01). Moreover, abnormal contralateral dFCD variability of the left middle temporal gyrus correlated with the severity of AVHs in the AVH group (r = −.319, p = .024). The findings demonstrate that abnormal temporal variability of interhemispheric and intrahemispheric dFCD in schizophrenia patients with AVHs mainly focus on the temporal and frontal cortices and thalamus that are pivotal components of auditory and language pathways.
Exome sequencing identifies PD‐L2 as a potential predisposition gene for lymphoma
Authors: Shao Jianming , Gao Lei , Leung Marco L. , Gallinger Bailey , Inglese Cara , Meyn M. Stephen , Del Gaudio Daniela , Das Soma , Li Zejuan 
Published: May 2022

AbstractTo investigate germline predisposition in lymphoma, we performed whole‐exome sequencing and discovered a novel variant (c.817‐1G>T) in programmed cell death 1 ligand 2 (PD‐L2) in a family with early‐onset lymphomas and other cancers. The variant was present in the proband with follicular lymphoma and his son with Hodgkin's lymphoma. It was in the terminal splice acceptor site of PD‐L2 and embedded in a putative enhancer of Janus kinase 2 (JAK2) and programmed cell death 1 ligand (PD‐L1). We also found that gene expression of PD‐L2, PD‐L1, and JAK2 was significantly increased. Using 3′ rapid amplification of cDNA ends (3′ RACE), we detected an abnormal PD‐L2 transcript in the son. Thus, the c.817‐1G>T variant may result in the elevated PD‐L2 expression due to the abnormal PD‐L2 transcript and the elevated PD‐L1 and JAK2 expression due to increased enhancer activity of PD‐L1 and JAK2. The PD‐L2 novel variant likely underlies the genetic etiology of the lymphomas in the family. As PD‐L2 plays critical roles in tumor immunity, identification of PD‐L2 as a germline predisposition gene may inform personalized immunotherapy in lymphoma patients.
Longitudinal dispersion affected by willow patches of low areal coverage
Authors: Västilä Kaisa , Oh Jungsun , Sonnenwald Fred , Ji Un , Järvelä Juha , Bae Inhyeok , Guymer Ian 
Published: May 2022

AbstractVegetation notably influences transport and mixing processes and can thus be used for controlling the fate of substances in the hydro‐environment. Whilst most work covers fully vegetated conditions, the novelty of this paper is to focus on flows with real‐scale flexible willow patches. We aimed to investigate how longitudinal dispersion varies according to the spatial distribution, density and coverage of the patches and to evaluate the explanatory power of predictors that consider the hydraulics, vegetation and channel geometry. Salt tracer experiments were performed in a trapezoidal channel where we established 3–4 m long and 1–1.6 m wide patches of artificial foliated willows that reproduced the shapes and plant densities observed on woody‐vegetated floodplains. We examined sparsely distributed patches with low areal/volumetric coverage of 6–11%, and non‐vegetated conditions for reference. Flow depths and surface widths were 0.7–0.9 and 6–7 m, respectively, and the mean flow velocities ranged at 0.3–0.6 m/s. The emergent patches generated from a negligible to over a four‐fold increase in the longitudinal dispersion when compared with non‐vegetated conditions. The patches with a preferential location in low‐velocity areas, such as near banks, or with a high plant density and a blockage of the cross‐sectional flow area ⪆0.4, led to the largest dispersion and residence times. Patches under such configurations enhanced the normalized differential velocity defined as the difference between the highest (90th percentile) and lowest (10th percentile) cross‐sectional flow velocities divided by the mean velocity, thus increasing shear dispersion. As existing analytical predictors failed to estimate the effect of different patch configurations, we proposed the change in the normalized differential velocity between vegetated and corresponding non‐vegetated conditions as a basic predictor of the reach‐scale longitudinal dispersion coefficient under patchy vegetation. In contrast, we observed no clear relationship between flow resistance and dispersion. Thus, our findings indicated that bankside vegetation may allow for reduced peak concentrations and lengthened residence times, supporting pollutant management, while ensuring good flow conveyance. Such rare field‐scale analyses improve the estimation of solute transport in real vegetated flows.
Study on painless gastroscopy and POCD of smoking patients under general anesthesia
Authors: Yu Wan‐Qiu , Zhu Yu‐Hang , Yang Xin‐Xin , Gong Tao‐Wu , Yu Zhen‐He , Wu Zhen‐Yu , Dong Liang , Zhu Zhao‐Qiong 
Published: May 2022

AbstractThe number of smoking patients receiving anesthesia and surgical treatment is increasing day by day. It will be useful for medical advancement to explore whether smoking is an independent risk factor for postoperative cognitive impairment. A double‐blind, parallel, and controlled study was conducted on 112 patients who fulfilled the criteria for inclusion in this study and planned to undergo painless gastroscopy under general anesthesia. The baseline mini‐mental state examination (MMSE) scores and basic information were collected. The changes in the MMSE scores after waking up and 3 days after anesthesia were observed, and the adverse events (respiratory adverse reactions, circulatory fluctuations, and adverse reactions, drug use, etc.) were analyzed by logistic regression. The baseline level of each group is consistent, which is worth studying. The MMSE score of the smoking group after anesthesia was significantly different from that of the control group (p < 0.05), but there was no significant difference between the two groups 3 days after anesthesia. Among them, the differences in adverse events between the two groups were in terms of hiccup, postoperative cough, and SpO2 < 90% (p < 0.05). Regression analysis indicates that smoking after anesthesia leads to the occurrence of postoperative cough. Smoking is probably an independent risk factor for post‐operative cognitive dysfunction (POCD) in early postoperative patients.
A nationwide certification system to increase the safety of highly advanced hepatobiliary‐pancreatic surgery
Authors: Otsubo Takehito , Kobayashi Shinjiro , Sano Keiji , Misawa Takeyuki , Katagiri Satoshi , Nakayama Hisashi , Suzuki Shuji , Watanabe Manabu , Ariizumi Shunichi , Unno Michiaki , Tanabe Minoru , Nagano Hiroaki , Kokudo Norihiro , Hirano Satoshi , Nakamura Masafumi , Shirabe Ken , Suzuki Yasuyuki , Yoshida Masahiro , Takada Yasutsugu , Nakagohri Toshio , Horiguchi Akihiko , Ohdan Hideki , Eguchi Susumu , Ohtsuka Masayuki , Sho Masayuki , Rikiyama Toshiki , Hatano Etsuro , Taketomi Akinobu , Fujii Tsutomu , Yamaue Hiroki , Miyazaki Masaru , Yamamoto Masakazu , Takada Tadahiro , Endo Itaru 
Published: May 2022

AbstractBackgroundTo ensure that highly advanced hepatobiliary‐pancreatic surgery (HBPS) is performed safely, the Japanese Society of Hepato‐Biliary‐Pancreatic Surgery (JSHBPS) board certification system for expert surgeons established a safety committee to monitor surgical safety.MethodsWe investigated postoperative mortality rates based on summary reports of numbers and outcomes of highly advanced HBPS submitted annually by the board‐certified training institutions from 2012 to 2019. We also analyzed summary reports on mortality cases submitted by institutions with high 90‐day post‐HBPS mortality rates and recommended site visits and surveys as necessary.ResultsHighly advanced HBPS was performed in 121 518 patients during the 8‐year period. Thirty‐day mortality rates from 2012 to 2019 were 0.92%, 0.8%, 0.61%, 0.63%, 0.70%, 0.59%, 0.48%, and 0.52%, respectively (P < .001). Ninety‐day mortality rates were 2.1%, 1.82%, 1.62%, 1.28%, 1.46%, 1.22%, 1.19%, and 0.98%, respectively (P < .001). Summary reports were submitted by 20 hospitals between 2015 and 2019. Mortality rates before and after the start of report submission and audit were 5.72% and 2.79%, respectively (odds ratio 0.690, 95% confidence interval 0.487‐0.977; P = .037).ConclusionsDevelopment of a system for designation of board‐certified expert surgeons and safety management improved the mortality rate associated with highly advanced HBPS.
Hybrid dragonfly algorithm and pattern search optimized adaptive fuzzy PID controller for frequency regulation of multi microgrid system using Henkel matrix based reduced‐order model
Authors: Mishra Sonalika , Nayak Pratap Chandra , Prusty Ramesh Chandra , Panda Sidhartha 
Published: May 2022

AbstractThis paper proposes frequency regulation of multi microgrid systems. The system under study consists of wind energy, solar energy and energy storage system operating in dissimilar combinations to establish equilibrium among the production and consumer demand. In this proposed work, stability analysis of the concerned model is studied using the Henkel matrix approach of the reduced‐order model. Again, an attempt is made to apply the adaptive fuzzy proportional integral and derivative (AFPID) controller for frequency control of the system. The optimal gains of the controllers are tuned by reducing the integral time absolute error using a hybrid dragonfly algorithm supported by the pattern search (hDAPS) algorithm. The efficacy of the proposed adaptive fuzzy controller is examined with fuzzy PID and PID for different cases of the concern system. The efficacy of the hDAPS algorithm is justified over the genetic algorithm, dragonfly algorithm and particle swarm optimization. The robustness study also reveals that the systems are offering reduced overshoot and undershoot under different scenarios of load and source environment. To demonstrate expediency of the proposed controller sensitivity analysis was carried out under different loading conditions. In addition, to show the efficiency of the hDAPS tuned AFPID controller, the outcomes were associated with other artificial intelligence methods reported in the literature.
Comparison of flood simulation capabilities of a hydrologic model and a machine learning model
Authors: Liu Lu , Liu Xiaomang , Bai Peng , Liang Kang , Liu Changming 
Published: May 2022

AbstractMachine learning models have been widely used for flood simulation. Few studies have compared the flood simulation capabilities of machine learning models and hydrologic models. This study compared the flood simulation capabilities of the SIMHYD hydrologic model and the LSTM machine learning model in 232 basins with different climate conditions. The results show that although the LSTM model significantly outperforms the SIMHYD model in the calibration period, it has significant performance degradation in the validation period. Basin characteristics had limited impacts on the performance difference between the LSTM model and the SIMHYD model. The extension of the calibration period improves the performance of the LSTM model, while it has a limited impact on the performance of the SIMHYD model. Thus, machine learning models are recommended for simulating floods if enough training data are available, otherwise, hydrologic models could be a better choice. This study is helpful to the choice of flood simulation models in different situations.
Risk Factors for Functional Outcomes in Advanced Laryngeal Squamous Cell Carcinoma
Authors: Lee David S. , Lee Jake J. , Sinha Parul , Puram Sidharth V. , Jackson Ryan S. , Adkins Douglas R. , Oppelt Peter , Brenneman Randall , Thorstad Wade L. , Pipkorn Patrik 
Published: May 2022

ObjectiveChemoradiation for patients with laryngeal squamous cell carcinoma (SCC) may achieve organ preservation, but appropriate patient selection remains unknown. This study investigates pre‐treatment risk factors associated with functional and survival outcomes after radiation‐based therapy in patients with advanced laryngeal SCC.MethodsA retrospective cohort study was performed on 75 adult patients with stage III or IV laryngeal SCC receiving definitive radiation‐based therapy from 1997 to 2016 at a tertiary care center. Tracheostomy and gastrostomy dependence were the primary functional outcomes. Multivariable logistic regressions were performed to evaluate relationships between pre‐treatment factors and tracheostomy and gastrostomy dependence. Time‐to‐event analyses were performed to determine risk factors associated with overall survival.ResultsAmong 75 patients included in the analysis, 30 (40%) patients were tracheostomy dependent and 31 (41%) were gastrostomy tube dependent. The median length of follow‐up was 31 months (range = 1 to 142 months). Pre‐treatment tracheostomy was a significant predictor of post‐treatment tracheostomy (aOR = 13.9, 95% CI = 3.35 to 57.5) and moderate–severe comorbidity was a significant predictor of post‐treatment gastrostomy dependence (aOR = 2.96, 95% CI = 1.04 to 8.43). The five‐year overall survival was 51% (95% CI = 38 to 64%). Pre‐treatment gastrostomy tube dependence was associated with an increased risk of death (aHR = 2.45, 95% CI = 1.09 to 5.53).ConclusionsBaseline laryngeal functional status and overall health in advanced laryngeal SCC are associated with poor functional outcomes after radiation‐based therapy, highlighting the importance of patient selection when deciding between surgical and non‐surgical treatment plans. Laryngoscope, 133:594–600, 2023
Novel homozygous pathogenic mitochondrial DNAJC19 variant in a patient with dilated cardiomyopathy and global developmental delay
Authors: Al Tuwaijri Abeer , Alyafee Yusra , Alharbi Mashael , Ballow Maryam , Aldrees Mohammed , Alam Qamre , Sleiman Rola A. , Umair Muhammad , Alfadhel Majid 
Published: May 2022

AbstractBackgroundDilated cardiomyopathy with ataxia syndrome (DCMA) or 3‐methylglutaconic aciduria type V is a rare global autosomal recessive mitochondrial syndrome that is clinically and genetically heterogeneous. It is characterized by early‐onset dilated cardiomyopathy and increased urinary excretion of 3‐methylglutaconic acid. As a result, some patients die due to cardiac failure, while others manifest with growth retardation, microcytic anemia, mild ataxia, and mild muscle weakness. DCMA is caused by variants in the DnaJ heat shock protein family (Hsp40) member C19 gene (DNAJC19), which plays an important role in mitochondrial protein import machinery in the inner mitochondrial membrane.MethodsWe describe a single affected family member who presented with cardiomyopathy, global developmental delay, chest infection, seizures, elevated excretion of 3‐methylglutaconic acid, and 3‐methylglutaric acid in the urine.ResultsWhole‐exome sequencing followed by Sanger sequencing revealed a homozygous frameshift variant in the reading frame starting at codon 54 in exon 4 in the DNAJC19 gene (c.159del [Phe54Leufs*5]), which results in a stop codon four positions downstream. Quantitative gene expression analysis revealed that DNAJC19 mRNA expression in this patient was substantially reduced compared to the control.ConclusionsWe present a novel variant in the DNAJC19 gene that causes rare autosomal recessive mitochondrial 3‐methylglutaconic aciduria type V. By comparing the current case with previously reported ones, we conclude that the disease is extremely heterogeneous for reasons that are still unknown.
Rare variant of TBL1XR1 in West syndrome: A case report
Authors: Shen Yajun , Yuan Meng , Luo Huan , Yang Zuozhen , Liang Mengmeng , Gan Jing 
Published: May 2022

AbstractBackgroundWest syndrome (WS) is an epileptic encephalopathy (EE) that begins in children 4–7 months of age (in rare cases older than 2 years). To date, over 30 genes that have been reported to be related to WS. Reports involving the extremely rare pathogenic gene, transducin beta‐like 1‐X‐ linked receptor 1(TBL1XR1) are quite limited.MethodsWe performed exome sequencing (ES) of family trios for this infant. We also collected and summarized the clinical data for reported heterozygous germline variants of TBL1XR1. Moreover, we reviewed all published cases and summarized the clinical features and genetic variants of TBL1XR1.ResultsES revealed a de novo variant in TBL1XR1 [NM_024665.5: exon4: c.187G > A (p.Glu63Lys)]. This variant was classified as likely pathogenic according to the ACMG (American College of Medical Genetics and Genomics) guidelines and was verified by Sanger sequencing. Further conservation analyses revealed a high conservation among several species. There was clinical heterogeneity among all patients with TBL1XR1‐related West syndrome.ConclusionOur results expand the pathogenic variant spectrum of TBL1XR1 and strengthen the pathogenic evidence of TBL1XR1 in West syndrome.
Organ‐level internal dosimetry for intra‐hepatic‐arterial administration of 99mTc‐macroaggregated albumin
Authors: Kappadath S. Cheenu , Lopez Benjamin P. 
Published: May 2022

AbstractPurposeThere are no published data on organ doses following intra‐hepatic‐arterial administration of 99mTc‐macroaggregated‐albumin (IHA 99mTc‐MAA) routinely used in 90Y‐radioembolization treatment planning to assess intra‐ and extra‐hepatic depositions and calculate lung‐shunt‐fraction (LSF). We propose a method to model the organ doses following IHA 99mTc‐MAA that incorporates three in vivo constituent biodistributions, the 99mTc‐MAA that escape the liver due to LSF, and the 99mTc‐MAA dissociation fraction (DF).MethodsThe potential in vivo biodistributions for IHA 99mTc‐MAA are: Liver‐Only MAA with all activity sequestered in the liver (LSF = 0&DF = 0), Intravenous MAA with all activity transferred intravenously as 99mTc‐MAA (LSF = 1&DF = 0), and Intravenous Pertechnetate with all activity is transferred intravenously as 99mTc‐pertechnetate (LSF = 0&DF = 1). Organ doses for Liver‐Only MAA were determined using OLINDA/EXM 2.2, where liver was modeled as the source organ containing 99mTc‐MAA, while those for Intravenous MAA and Intravenous Pertechnetate were from ICRP 128. Organ doses for the general case can be determined as a weighted‐linear‐combination of the three constituent biodistributions depending on the LSF and DF. The maximum‐dose scenario was modeled by selecting the highest dose rate for each organ amongst the three constituent cases.ResultsFor Liver‐Only MAA, the liver as source organ received the highest dose at 98.6 and 126 mGy/GBq for the adult male and adult female phantoms, respectively; all remaining organs received <27 and <32 mGy/GBq. For Intravenous MAA, the lung as source organ received the highest dose at 66 and 97 mGy/GBq; all remaining organs received <16 and <21 mGy/GBq. The organ with the highest dose for Intravenous Pertechnetate was the upper‐large‐intestinal wall at 56 and 73 mGy/GBq; all remaining organs received <26 and <34 mGy/GBq. The liver and lung doses for the maximum‐dose scenario with 5 mCi (185 MBq) 99mTc‐MAA were estimated at 18.2 and 12.2 mGy, and 23.3 and 17.9 mGy, for the adult male and adult female phantoms, respectively.ConclusionOrgan dose estimates following IHA 99mTc‐MAA based on constituent biodistribution models and patient‐specific LSF and DF values have been derived. Liver and lung were the organs with highest dose, receiving at most 15–25 mGy in the maximum‐dose scenario, following 5 mCi IHA 99mTc‐MAA.