bluuebunny/crossref_metadata_2025_split huggingface dataset:
Seismic evidence for uniform crustal accretion along slow-spreading ridges in the equatorial Atlantic Ocean
Authors: Wang Zhikai , Singh Satish 
Published: February 2022

Abstract
The crustal accretion along mid-ocean ridges is known to be spreading-rate dependent. Along fast-spreading ridges, two-dimensional sheet-like mantle upwelling creates relatively uniform crust. In contrast, the crust formed along slow-spreading ridges shows large along-axis thickness variations with thicker crust at segment centres, which is hypothesised to be due a three-dimensional plume-like mantle upwelling with melt focusing to segment centres. Using wide-angle seismic data acquired from the equatorial Atlantic Ocean, we show that the crustal thickness is nearly uniform (~5.5 km) across five segments for crust formed at the slow-spreading Mid-Atlantic Ridge with age varying from 8 to 70 Ma. The crustal velocities indicate that this crust is predominantly of magmatic origin. We suggest that this uniform magmatic crustal accretion is due to a two-dimensional sheet-like mantle upwelling, contradicting previous hypothesis. Our results also indicate that the lateral extend of magmatic accretion could be used to define the sheet-like mantle upwelling regions beneath the global ridge system.
Early life microbial exposures shape the Crassostrea gigas immune system for lifelong and intergenerational disease protection
Authors: Fallet Manon , Montagnani Caroline , Petton Bruno , Lorgeril Julien , Comarmond Sébastien , Chaparro Cristian , Toulza Eve , Boitard Simon , Escoubas Jean-Michel , Vergnes Agnès , Grand Jacqueline Le , Bulla Ingo , Gueguen Yannick , Vidal-Dupiol Jérémie , Grunau Christoph , Mitta Guillaume , Cosseau Céline 
Published: February 2022

Abstract
Background
The interaction of organisms with their surrounding microbial communities influences many biological processes, a notable example of which is the shaping of the immune system in early life. In the Pacific oyster, Crassostrea gigas, the role of the environmental microbial community on immune system maturation – and, importantly, protection from infectious disease – is still an open question.
Results
Here, we demonstrate that early life microbial exposure durably improves oyster survival when challenged with the pathogen causing Pacific Oyster Mortality Syndrome (POMS), both in the exposed generation and in the subsequent one. Combining microbiota, transcriptomic, genetic, and epigenetic analyses, we show that the microbial exposure induced changes in epigenetic marks and a reprogramming of immune gene expression leading to long-term and intergenerational immune protection against POMS.
Conclusions
We anticipate that this protection likely extends to additional pathogens and may prove to be an important new strategy for safeguarding oyster aquaculture efforts from infectious disease.
Low-Loss Coupling from Coated Plano Convex Lens to Single Mode Solid Core Fibers Laser by Lensing Scheme
Authors: Khan Noor Zamin , Sohail Muhammad , Khan Noor Zamin , Mehmood Ikhtisham , Chen Tenghui , Khan Sayed Ali 
Published: February 2022

Abstract
For the first time, to the best of our knowledge, we experimentally demonstrated the new scheme for a coated Plano-convex lens (CPCL) fiber with a maximum coupling efficiency \((\eta\)max). In the single-mode solid core fiber (SMSCF), the fiber coupling efficiency is ~ 68% injected pump power 632.8 nm (1.5-dB loss was measure with a laser diode) which is difficult to achieve by using conventional technology, and also we reported, without fiber tapering technology has been used to realize low loss coupling from CPCL to SMSCF at low power level, and compare with published data. This is very useful for implementing all optical fiber systems. In addition, it also investigates the effect of bending the output power and beam profile of SMSCF. The Gaussian-like output beam profile is maintained up to \(\cong 7cm\) bending radius. The output mode field with good beam quality shows the mode filtering characteristics of SMSCF. Finally, the result of the fiber coupling efficiency (FCE) illustrates that the scheme of the lens coupling system is the most sensitive scheme to the misalignment and the lensing scheme is the least sensitive to misalignment.
A Control Method with Considering Error Coupling in Milling Multi Feature Thin-Walled Parts
Authors: Zuo Xiaoyan , Zhou Yin , Xiong Tao , Zhang Chengjun , Zhang Chi , Zhou Xiangyang 
Published: February 2022

Abstract
The error coupling analysis is important for machining accuracy of thin-walled parts. However, most of the error coupling analysis methods only based on multiple error sources with a single feature, without considering the coupling relationship of these errors between features. This paper no longer focuses on analyzing the machining error of a single feature, but discusses the error coupling phenomenon between each other and interrelated features. First, interactive factors during machining multiple features are analyzed. Subsequently, according to the main interactive factors, the models about geometric interaction and machining interaction of multi feature processing are established. Afterwards, based on the comprehensive error model obtained through the transformation of the coordinate systems, an efficient error control method of multi feature thin-walled parts is proposed. Finally, the approach has been validated through an illustrative case study using a sample part with complex machining features.
Short (seven days) versus standard (fourteen days) oestrogen administration in a programmed frozen embryo transfer cycle: a retrospective cohort study
Authors: Jiang Wen-Jing , Song Jing-Yan , Sun Zhen-Gao 
Published: February 2022

Abstract
Research question: What influence does seven days of oestrogen administration versus fourteen days have on the reproductive outcomes of frozen-thawed embryo transfer (FET) in programmed endometrial preparation cycles?
Design: In a retrospective study, conducted at a university-affiliated tertiary hospital, a total of 2628 infertile patients (4142 FET cycles) were divided into one of two groups between January 2014 and December 2020: group A (n=1406, seven days of oestrogen before progesterone (P4) supplementation) and group B (n=2716, fourteen days of oestrogen before P4 supplementation). The primary outcome was cumulative live birth rate (CLBR). Secondary outcomes were other pregnancy-related outcomes, maternal and neonatal complications.
Results: No significant difference in CLBR was observed when comparing seven versus fourteen days of oestrogen administration before starting P4 supplementation (47.6% vs. 48.8%, P=0.537). Furthermore, multivariable logistic regression analysis revealed that oestrogen administration in programmed FET cycles (7 days vs. 14 days) was not significantly associated with CLBR (OR 1.04, 95% CI 0.89-1.23). The risks of maternal and neonatal complications were comparable between the two groups.
Conclusions: Variation in the duration of oestradiol supplementation before P4 initiation does not impact FET reproductive outcomes. For infertile women who desire to conceive as soon as feasible, short (seven days) oestrogen administration in a programmed FET cycle may be a suitable alternative.
Trophoblast Cell-Surface Antigen 2 (TROP2) Expression in Triple-Negative Breast Cancer
Authors: Jeon Yeonjin , Jo Uiree , Hong Jongmoo , Gong Gyungyub , Lee Hee Jin 
Published: February 2022

Abstract
Background Trophoblast cell-surface antigen 2 (TROP2) is related to tumor proliferation enhancement and poor prognosis. An antibody targeting TROP2 was developed to treat metastatic triple-negative breast cancer (TNBC) which has a limited treatment modality. To characterize the TROP2 expressing tumors in TNBC, we analyzed TROP2 expression in three cohorts; (1) primary tumor without neoadjuvant chemotherapy, (2) primary tumor with neoadjuvant chemotherapy, and (3) metastatic tumor. Methods A total of 807 TNBC cases were evaluated for TROP2 immunohistochemical expression. We evaluated the TROP2 H-score distribution in the three cohorts. Tumors were divided into two groups based on TROP2 expression (high vs. low). We analyzed the relationship between clinicopathologic features and markers, including EGFR, CK5/6, p53, and Ki-67, and prognostic significance at high vs. low TROP2 expression. Results There was no difference in TROP2 H-score distribution between the three cohorts. Moderate-to-strong membranous expression of TROP2 in at least 10% of tumor cells was present in 662 cases (82.0%) in Cohort 1, 59 cases (89.4%) in Cohort 2, and 23 cases (88.5%) in Cohort 3. There was no significant difference in clinicopathologic features between high vs. low TROP2 in all cohorts. TROP2 H-score was an independent poor prognostic factor for overall survival in Cohort 3. Conclusion TNBC showed similar TROP2 expression regardless of neoadjuvant treatment or primary tumor/metastasis. Although the prognostic significance of TROP2 expression in metastatic TNBC has been revealed, further evaluation of the predictive value of TROP2 expression for targeted therapy is needed.
Changing in Dental Setting and Postural Analysis – A Case Report
Authors: Palandri Sergio 
Published: February 2022

Abstract
BackgroundDental structure and posture is now well known to be closely linked to each other. This work is not intended to be the definitive proof of this link, but rather the exposure of a case that presents the particularity of an absolute procedural asepsis as the operator was not aware of the change in the dental setting of the subject examined.Material sand MethodsThe study began in 2020 and ended in 2021. The subject involved was a young woman of about 37 years old, weighing 52Kg and 1.58m tall, at the first postural analysis performed on 2020 January the third. Subsequently, two other postural analysis were performed, 13 months and 22 months after the first respectively. For the postural analysis, an identical protocol was followed in the three analyzes performed.ResultsObserving the results obtained in the three analysis, it can be deduced that approximately 63% of the controlled parameters (12 out of 19) underwent modifications, even if not all of them could be related to the variation of the dental setting.ConclusionThe study, even within the limits of its design, highlights how the different systems that make up the human body are interdependent and an action performed on one of them can be found as a modification of the initial state of others.
Sexual Dimorphism in Reactive Oxygen Species Production and a Role for Integrin alpha 1 beta 1 in Estrogen Receptor Expression in Articular Cartilage
Authors: Black Alicia L. , Haskins James , Pozzi Ambra , Clark Andrea L. 
Published: February 2022

Abstract
Background
Integrin α1β1 protects against osteoarthritis more robustly in females compared to males potentially through its influence on epidermal growth factor receptor (EGFR). The purpose of this study was to investigate the impact of itga1 on chondrocyte EGFR activity and downstream reactive oxygen species (ROS) production in male and female mice. Furthermore, chondrocyte expression of estrogen receptor (ER) α and ERβ were measured to investigate the mechanism for sexual dimorphism in the EGFR/integrin α1β1 signaling axis.
Methods
Femoral and tibial cartilage of male and female, wild type and itga1-null mice were processed for ex vivo confocal imaging of ROS, immunohistochemical analysis of 3-nitrotyrosine, or immunofluorescence of pEGFR and ERα and ERβ.
Results
We show that ROS producing chondrocytes are more abundant in female itga1-null compared to wild type mice ex vivo, however itga1 had limited influence on the percent of chondrocytes stained positively for 3-nitrotyrosine or pEGFR in situ. In addition, we found that itga1 influenced ERα and β expression in femoral cartilage from female mice, and that ERα and β were co-expressed as well as co-localized in chondrocytes. Finally, we show sexual dimorphism in ROS and 3-nitrotyrosine production, but surprisingly not in pEGFR expression.
Conclusions
Together these data highlight sexual dimorphism in the EGFR/integrin α1β1 signaling axis and underline the need for further investigation into the role of ERs in this biological paradigm. Understanding the molecular mechanisms underlying the development of osteoarthritis is essential for the development of individualized, sex-specific treatments in this age of personalized medicine.
Concurrent intracranial malignant triton tumor and relapsed pituitary adenoma in the sellar region: a case report and review of the literature
Authors: liu bin , Wang Jinchao , xu shangchen 
Published: February 2022

Abstract
Background: Malignant triton tumor (MTT) is a rare kind of malignant peripheral nerve sheath tumors, histologically characterized by rhabdomyoblastic differentiation. There are limited reports of MTT occurring in the intracranial area. The treatment modality consisting of total surgical resection plus post-operative radiotherapy is generally accepted. However, even with optimal treatment, most patients will die within a few months. Case presentation: We report a 71-year-old man with a history of pituitary adenoma, who underwent surgical treatment and postoperative gamma knife therapy. Magnetic resonance imaging (MRI) of the brain revealed a mass with two distinctive components in the sellar area. Postoperative pathology found that the lesion is consisted of a MTT and a relapsed pituitary adenoma. Conclusions: The present case is the first report of MTT that occurred in the sellar area. It is also the first case of intracranial MTT with other concurrent tumors (relapsed pituitary tumors). Meanwhile, this case has a clear history of radiation, suggesting that the occurrence of MTT may be related to radiation.
Digital Pathology in Latin America
Authors: García-Rivello Hernán , Cancio Alfredo , Monroy Ana Maria Vanegas , Soares Fernando Augusto , García Franco Doimi , Puyol Jorge Ugalde , Schultz Marcela , Díaz Nicolás Vivar , Zoroquiain Pablo , Soria-Céspedes Danny 
Published: February 2022

Abstract
Background: Digital pathology (DP) adoption in Latin America has expanded slower than in developed regions, probably due to many barriers not seen in the latter areas. This article aims to present the current scenario in the region, highlighting barriers and possible solutions to encourage its adoption in Latin American countries.Methods: An expert panel of 9 Latin American medical pathologists and 1 information technology specialist participated in an online modified Delphi panel, utilizing a third-party platform (iAdvise, Within3, USA). Thirteen pre-prepared questions were answered interactively.Results: Experts' observations confirm the paucity of labs in the region that utilize digital pathology technology. The panel ranked obtaining second opinions and presenting images remotely as the main benefit of a digital pathology system, although many others were cited as well. Cost of implantation was the main barrier mentioned by the experts, and payers' and decision makers' lack of awareness of benefits ranked second as a barrier to DP implementation. Internet infrastructure was also mentioned as a concerning issue in the region. Besides diagnostic pathology services, proposed revenue incomes included commercialization of digital services to other institutions, loan agreements of equipment and software, and organizing courses for pathologists or residents. The need for alternative reimbursement methods for diagnostic services was also mentioned. A regional network of collaborating institutions was also suggested as a viable solution to reach distant areas and laboratories lacking the technology.Conclusions: The benefits of DP are clear to the expert panel, but cost and lack of awareness of its benefit may be hampering its widespread adoption in Latin America.
Risk of superinfection in critically ill COVID-19 patients receiving tocilizumab plus dexamethasone
Authors: CAMOU FABRICE , ISSA NAHEMA , HESSAMFAR MOJGAN , GUISSET OLIVIER , MOURISSOUX GAELLE , PEDEBOSCQ STEPHANE , MINOT AIMEE , BONNET FABRICE 
Published: February 2022

Abstract
To assess the risk of superinfection in patients with severe COVID-19 in an ICU receiving dexamethasone with or without tocilizumab, we performed an observational cohort study. Of 246 patients, 59 developed superinfections (mainly respiratory) leading to poorer prognoses. Adding tocilizumab to dexamethasone was not associated with an increased risk of superinfection in these patients.
Investigation of the Biological Treatability of Pistachio Processing Industry Wastewaters in a Batch-operated Aerobic Bioreactor
Authors: Kul Sinan , Tırınk Sevtap , Nuhoğlu Alper 
Published: February 2022

Abstract
This study encompasses investigation of treatment of pistachio processing industry wastewaters in a batch reactor under aerobic conditions, calculation of kinetic parameters and comparison of different inhibition models. The mixed microorganism culture used in the study was adapted to pistachio processing industry wastewaters for nearly one month and then concentrations from 50-1000 mg L -1 of pistachio processing industry wastewaters were added to the medium and treatment was investigated in batch experiments. The Andrews, Han-Levenspiel, Luong and Aiba biokinetic equations were chosen for the correlations between the concentration of pistachio processing industry wastewaters and specific growth rates, and the kinetic parameters in these biokinetic equations were calculated. The maximum specific growh rate, semi-saturated constant and inhibition constant parameters, included in the Aiba biokinetic equation providing best fit among the other equations, had values calculated as 0.25 h -1 , 19 mg L -1 , and 516 mg L -1 , respectively. The substrat value reaches maximum value and the specific growth rate at this concentration were calculated as 101.379 mg L -1 and 0.1827 h -1 , respectively
Genome-Wide Association Study Revealed Loci Linked To Post-Drought Recovery And Traits Related To Persistence Of Smooth Bromegrass (Bromus Inermis)
Authors: Saeidnia Fatemeh , Majidi Mohammad Mahdi , Mirlohi Aghafakhr , Ahmadi Benyamin 
Published: February 2022

Abstract
Association analysis has been proved as a powerful tool for genetic dissection of complex traits. This study was conducted to identify marker–trait associations for recovery, persistence, and as well as finding stable associations. In this study, a diverse panel of polycross derived progenies of smooth bromegrass was phenotyped under normal and water stress, during three consecutive years. Association analysis was performed between nine important agronomic traits along with three seasonal growth activity indices based on 535 SRAP markers. Population structure analysis identified five main subpopulations possessing significant genetic differences. Association analysis using mixed linear mode1 identified 339 and 233 marker-trait associations under normal and water stress environments, respectively. Some of these markers were associated with more than one trait; which can be attributed to pleiotropic effects or to a number of tightly linked genes affecting several traits. If the effectiveness of these markers in genetic control of these traits is validated, they could be potentially used for initiation of marker-assisted selection and targeted trait introgression of smooth bromegrass under normal and water stress environments.
Expression Patterns of Ras-Association Domain Family Genes and Their Prognostic Values in Gastric Cancer
Authors: Wen Fei , Qu Haixia , Jiang Xiangjun 
Published: February 2022

Abstract
Background
Ras-association domain family (RASSF) members are a set of proteins involved in cell cycle control and apoptosis and they are generally considered as tumor suppressors.
Objective
The present study aimed to elucidate the expression patterns of RASSFs and their prognostic values in gastric cancer.
Methods
The Oncomine and UALAN online databases were used for analyzing the expression patterns of RASSFs in gastric cancer patients and Kaplan-Meier online database was used for analyzing the prognostic values of RASSFs. The STRING database was used to establish the protein-protein interaction network. Gene ontology (GO) analysis and the Kyoto Encyclopedia of Genes and Genomics (KEGG) enrichment analysis were performed by using clusterProfiler package. Finally, MEXPRESS was used for analyzing DNA methylation.
Results
It was found that RASSF 1 was upregulated in gastric cancer and associated with a better prognosis, whereas RASSF7 was also upregulated in gastric cancer, but associated with a worse prognosis. Enrichment analysis further explained RASSFs association with Ras by regulation of GTP/GDP binding. RASSF genes showed different methylation levels in gastric cancer.
Conclusions
In conclusion, RASSF members are differentially expressed in gastric cancer, and could be potential prognostic biomarkers in gastric cancer.
Hybrid Trust and Weight Evaluation Based Trust Assessment Using ECK-ANFIS and AOMDV-REPO Based Optimal Routing in MANET Environment
Authors: Dupak Lucindia , Banerjee Subhasish 
Published: February 2022

Abstract
In Mobile Ad hoc NETworks (MANET), the employment of trust-based routing has attained augmenting attention during the past years. A novel approach for ensuring dependable routing in an adversarial MANET is the Trust-based routing protocols. Most prevailing works were done on the routing protocols development for security augmentation on an adversarial environment. These protocols encompass some flaws and are not secured on the MANET environment. This research method utilizes the Exponential Cauchy Kernelized Adaptive Neuro-Fuzzy Inference System (ECK-ANFIS) centered trust assessment utilizing Hybrid Trust (HT) evaluation along with optimal routing on the MANET for tackling those issues. In this proposed model, the nodes are first initialized; next, ECK-ANFIS assessed the trust. For the evaluation, the HT together with the weight value is estimated for the nodes. Subsequently, the lower-level Trust Value (TV) nodes are secluded into a separate box. Next, the cluster is created on the trusted node. Improved K-Harmonic Mean (IKHM) algorithm forms the Cluster Head (CH). Ad hoc On-demand Multi-path Distance Vector (AOMDV) discovered the route. Range Emperor Penguin Optimization (REPO) selects the optimal route as of the manifold nodes. Next, the route is maintained utilizing the same algorithm. In the investigational study, the performance is examined with the prevailing methods centered upon performance metrics. Therefore, the better performance of the proposed work is proved.