bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Association between Body Mass Index and Lifestyle with Academic Performance of College of Medicine Students, Majmaah University, Saudi Arabia
Authors: Mohamed Elsadig Yousif , Sami Waqas , Almhmd Abdalah Emad , K Alenazy Sultan Homdi , Alrashidi Abdulrahman Ghayeb , Aldhafeeri Bassam Mashhi , Binmuhareb Abdulaziz Nasser 
Published: November 2022

Introduction:Obesity rates have risen rapidly in both industrialised and developing countries, across all age groups and genders. The researchers wanted to see if there was a link between body mass index (BMI) and lifestyle and academic performance among College of Medicine students at Majmaah University in Saudi Arabia.Materials and Methods:Male and female students studying at college of medicine who were registered for the academic year 2020–2021 studying in levels 2–6 were included in this cross-sectional study. A total of 269 participants were chosen as part of the sample. A pretested questionnaire was used to collect the information.Results:Males made up more than half of the participants (153, or 56.6%), with the majority (245, or 91.1%) being between the ages of 17 and 24 years. Participants' BMIs ranged from 15.2 to 43.2, with an average SD of 24.5 5.3. One hundred and fifty (55.8%) of the kids were of average weight. The statistical research indicated a link between cumulative grade point average (CGPA) and BMI. In comparison to the rest, normal-weight participants had a higher CGPA.Conclusion:Being a male, younger age, high family income, second-year level and parents' education are all linked to strong academic achievement, according to the study. Normal weight, nutritional and sleeping habits are also linked to good academic performance.
The Potential Selective Oncolytic Effects of Newcastle Disease Virus (NDV) on Cervical and Colon Cancer Cell Lines
Authors: Girish Jyothsna , Ulag Lorina Handayani , Marcello Fabian , Liko Alvaro Filbert , Sanjaya Nathaniel Alvin , Ciputra Edward , Elvira Sharleen , Yonatan Kenny , Tanissa Monica Angel , Setiawan Yosua Nungky , Fanusi Felic , Gustiananda Marsia 
Published: November 2022

The mesogenic and velogenic strains of the avian Newcastle Disease Viruses (NDV) have been investigated for use in cancer virotherapy. However, despite its promising results, these strains have the potential to cause outbreaks leading to morbidity and mortality in large numbers of avians that can devastate the poultry industry. Therefore, there is a growing interest towards the use of lentogenic strains such as NDV LaSota vaccine strain for virotherapy. This study investigated the oncolytic potential of the NDV LaSota strain on colorectal cancer (HT29) and cervical cancer (HeLa) cell lines. The NDV LaSota stain was propagated in pathogen free embryonated chicken eggs and quantified using a hemagglutination assay. The oncolytic activity was evaluated by comparison of HT29 and HeLa cell lines to the non-cancerous human embryonic kidney (HEK293) cell line using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) viability assay. The highest NDV concentration of 16 HAU was found to reduce the viability of HT29, HeLa, and HEK293 cell lines to 42±3% (p = 0.0001), 49±12% (p = 0.0009), and 77±5% (p = 0.007), respectively, indicating its potential selective cytotoxicity, as supported by the disturbed cell morphology. The NDV LaSota strain exhibits a potential selective oncolytic activity towards cancer cell lines, thus may serve as an interesting candidate for virotherapy against colorectal and cervical cancer.
Are the communications of African flight attendants a form of slurred speech?
Authors: Negedu Isaiah A. , Sule Peter Echewija 
Published: November 2022

Onboard international flights, you may have witnessed the pre-takeoff information/in-flight safety speech by the cabin crew. It is not out of place that they tend to be European in their mode of speaking. However, when on a local flight, the Europeanness of speech still comes out loud. We want to understand why such Europeanised intonation should be and the audience it is meant to serve. Our research leads us to the conclusion that this insensitivity of local airline operators stems from the desire to enjoy some patronage even if their actions inferiorise the community who are the major patronisers of their services. We will also explain why the Europeanisation of speech could lead to safety hazards. This work is inspired by the personal experiences of the researchers and of a few others.
Communication Patterns in Editorial Management at ITB Press Bandung
Authors: Gumilar Gun Gun Waldi , Wibowo Sulistiyo , Andrian Andrian 
Published: November 2022

This research aims to determine the effectiveness of implementing communication patterns in editorial management at ITB Press, a university book publisher within the Bandung Institute of Technology (ITB). Using descriptive writing, the researchers describe the editorial management communication pattern at ITB Press. Based on observations of the work steps carried out at ITB Press, it is proven that all manuscripts are monitored for their existence, complete with authors and the status of the publishing work process at the time of recording. The conclusion is that the editorial management communication pattern carried out at ITB Press has been running effectively as expected. However, ITB Press should continue to develop, improve, and perfect the system, if necessary, in accordance with the demands of the times and technology, to make all of its work more effective.
Pengaruh Metode Demonstrasi Terhadap Kemampuan Menulis Teks Prosedur Kompleks
Authors: Tampubolon Tasya , Tambunan Marlina Agkris , Saragih Vita Riahni , Sirait Jumaria , Siregar Junifer 
Published: November 2022

Penelitian ini bertujuan untuk mengetahui pengaruh metode demonstrasi terhadap kemampuan menulis teks prosedur kompleks pada siswa kelas VII SMP Satrya Budi Karang Rejo.Jenis penelitian ini adalah penelitian eksperimen (Pre Experimen). Metode pengumpulan data dalam penelitian ini adalah metode kuantitatif, dengan teknik tes. Hasil penelitian yang diperoleh (1) Kemampuan menulis teks prosedur kompleks (pre-test) siswa kelas VII SMP Satrya Budi Karang Rejo sebelum menggunakan metode demonstrasi diperoleh nilai rata-rata 55,58 (2) Kemampuan menulis teks prosedur kompleks (post-test) siswa kelas VII SMP Satrya Budi Karang Rejo sesudah menggunakan metode demonstrasi diperoleh nilai rata-rata 71,96 (3) Hasil Perhitungan uji thitung (2,44) > ttabel (1,697) sehingga hipotesis yang dianjurkan H? ditolak dan Ha diterima. Dengan demikian dapat disimpulkan bahwa terdapat pengaruh signifikan metode demonstrasi terhadap kemampuan menulis teks prosedur kompleks pada siswa kelas VII SMP Satrya Budi Karang Rejo.
AS TECNOLOGIAS DIGITAIS DE INFORMAÇÃO E COMUNICAÇÃO NO CONTEXTO DA EDUCAÇÃO BÁSICA
Authors: Alves Guimarães Ueudison , Pereira da Silva Veralucia , Meire de Oliveira Barros Rose , Reis Pacheco Juliana 
Published: November 2022

O presente artigo discorre sobre a relação entre as Tecnologias Digitais de Informação e Comunicação (TDICs) no processo de ensino e aprendizagem na Educação Básica e formação integral do educando, na qual vem ganhando espaço a cada ano, principalmente após os anos de pandemia mundial. Neste mesmo sentido, ao estar envolvida com a educação, houve o interesse em aprofundar sobre a temática envolvendo o ensino e as TDICs no Currículo escolar. Procurou- se apresentar o processo que ocorreu na sociedade para a inserção da tecnologia e as primeiras máquinas, para só anos mais tarde estarem inseridas no ambiente escolar e em sala de aula. Utilizou-se de os documentos como a Base Nacional Comum Curricular (BNCC), Lei de Diretrizes e Bases da Educação (LDB) que regem a educação e abordam sobre o uso da tecnologia no contexto educacional. O professor, enquanto mediador de conhecimento, pode inserir o uso das tecnologias no seu método de ensino, trabalhar com os alunos os recursos presentes na educação para promover a aprendizagem, pois nos dias atuais os alunos possuem acesso à tecnologia e juntamente com os professores haverá uma transmissão e troca de conhecimento por ambas as partes.
Refugees and National Security in Kenya: A Case Study of Eastleigh, Kamukunji Constituency, Nairobi County
Authors: Otieno Erick Ochieng , Mwikali Felistus , Paul Norvy 
Published: November 2022

Purpose: This study is about refugees and national security in Kenya: Case Study of Eastleigh, Kamukunji Constituency, Nairobi County. The research examined whether refugees are a threat to national security, evaluated the relationship between refugees and terror activities and examined whether the Kenya’s open-door policy on refugees is a threat to national security. This research was guided by conceptual framework on what national security is and threats to national security, as well as refugees and the security threats they pose to Kenya. Push and Pull Theory and Securitization Theory further guided the research.
Methodology: The study was conducted using Mixed Methods research design that incorporated both qualitative and quantitative approaches in data collection, data analysis and interpretation of the findings. The research instruments for data collection were questionnaire and one on one interviews with refugees and relevant key stakeholders such as UNHCR, Danish Refugee Council, and Ministry of Interior and Coordination of National Government. Secondary data was obtained from books, published scholarly materials, internet publications, field research report, theses, journals, government reports, newsletters, and newspapers.
Findings: The respondents indicated that there was a relationship between refugees and terror activities in Kenya. Majority of the respondents indicated that policies and laws were the best approaches in dealing with refugees related insecurity, thus effective policies, laws, and best approaches are required to stem the high levels of insecurity. Encampment policy did not provide sustainable solution, majority of the respondents indicated that non-refoulement refugee policies and laws, refugee settlements, local integration, voluntary repatriation was a strategy and durable solutions in dealing with refugees and insecurity, while other respondents proposed expulsion of refugees involved in criminal activities and screening of refugees for security threats, as the best approaches in dealing with refugees related insecurity. Measures against errant refugees and regulation of border entries to prevent illegal and criminal immigrants was also proposed.
Unique contribution to theory, practice and policy: This research recommends that United Nations, World Bank, and IMF should facilitate peace keeping missions and strengthen the government institutions in countering displacements, with emphasis on resettlement and integration of refugees especially those who cannot return to their country of nationality. Approaches that foster peace and security, such as Nyumba Kumi initiatives led by the security agencies like Ministry of Interior and Coordination of National Government, should continue to bring refugees, host community, development partners in both NGO and public sector and other stakeholders on board.
Ensemble Pharmacophore Meets Molecular Docking: A Novel Screening Approach for the Identification of B-Raf Kinase Inhibitors
Authors: Sunkara Muni Sireesha , Kuchana Vinutha , Vemuri Jyothi , Bhowmik Dipankar 
Published: November 2022

In US about 106110 diagnosed as melanomas, 7,180 people expected to die due to melanoma. B-RAF is a cytoplasmic serine - threonine kinase that is found in a mutated form in melanoma and colorectal cancer. Sorafenib was initially introduced as a B-RAF inhibitor in melanoma. Hence it is taken as a pivot molecule in our study. Four potent B-Raf kinase inhibitors (Sorafenib, Regorafenib, N-desmethyl sorafenib & Donafenib) are used to build a pharmacophore model with ‘PharmaGist webserver’ which generated a 5-point hypothesis. The best model with score of 27.780, was used to screen the Zinc database of ZINCPharmer web server to obtain similar pharmacophore hits. By applying filters like Lipinski rule, RMSD criteria in ZINCPharmer top ten hits were identified. Subsequently, molecular docking was performed on wild (1UWH) and mutated (3IDP) B-Raf kinase protein targets by using GLIDE 5.6 (Schrödinger), to prioritize top lead molecules. Further these molecules are subjected to ADME Properties Prediction by Qik Prop module. Among ten, nine molecules have glide scores in the range nearer to the standard molecule i.e., Sorafenib. Finally, we conclude that ZINC02853810 may act as a powerful inhibitor against both wild and mutant type B-Raf kinase as it has highest glide scores than the Standard.
GRAPHICAL ABSTRACT
Hastaların Hemşirelik Bakımını Algılayış Düzeylerinin Değerlendirilmesi
Authors: ARSLAN Canan , SOBCALI Sefa , DEMİRKAN Tuğba 
Published: November 2022

Giriş: Hemşirelik bakımı ile hastanın tüm ihtiyaçlarının giderilmesi ve beklentilerinin karşılanması, tedavi sürecini olumlu etkileyerek bakım kalitesini desteklemektedir.Amaç: Bu araştırma, hastaneye yatan hastaların hemşirelik bakımını algılayışlarını belirlemek amacı ile planlanmıştır.Yöntem: Tanımlayıcı olarak planlanan araştırma; bir devlet hastanesinin yataklı servislerinde taburculuğuna karar verilmiş 400 hasta ile yürütülmüştür. Çalışmanın verileri Hasta Bilgi Formu (HBF) ve Hastanın Hemşirelik Bakımını Algılayışı Ölçeği (HHBAÖ) ile toplanmıştır.Bulgular: Hastaların yaş ortalaması 55,25 olup, %52,3’ü kadındır. Hastaların %71,8’inin daha önce hastane geçmişinin olduğu ve %42,8’inin 1-2 gün süre ile hastanede kaldıkları belirlenmiştir. Hastaların “Hemşirelik Bakımını Algılayışı (HHBAÖ) Ölçeği’nden” aldıkları ortalama puan 3,70±0,60 olarak saptanmıştır. Hastaların %43’ü ‘hemşirelerin kendilerinin gerçekçi olmalarına yardımcı olduklarını, %33’ü ‘hemşirelerin kendileriyle hemen ilgilendiklerini’ belirtmişlerdir. Hastaların %9’u ise ‘hemşirelerin hastalıklarının kendileri için ne demek olduğunu anlamadıklarını’ ifade etmiştir.Sonuç: Araştırma bulgularına göre hastaların hemşirelik bakımından memnuniyetleri orta düzeyde bulunmuştur. Hemşirelerin hastayı daha iyi anlayabilmeleri için empati yeteneğinin geliştirilmesi ve bakım kalitesinin arttırılmasını destekleyici çalışmalara katılmaları önerilmektedir.
Política industrial
Authors: Arriola Palomares Joaquín 
Published: November 2022

Evaluación de las diferentes posturas del gobierno, la empresa privada y los académicos sobre la reconversión industrial. Para el autor, no tiene sentido plantear ahora la apertura de un proceso de reconversión industrial, sin haber definido antes los criterios de la integración regional. También cuestiona seriamente los conceptos que los sectores neoliberales salvadoreños manejan de la reconversión industrial y llama la atención de lo que se debería entender por tal y hacia dónde deberían orientarse las políticas económicas para conseguirla efectivamente.
ECA Estudios Centroamericanos, Vol. 46, No. 515, 1991: 815-827.
guerra en el segundo año del gobierno de ARENA
Authors: Sermeño Angel 
Published: November 2022

Análisis de la conducción y desarrollo de la guerra a partir del hecho incuestionable del empate militar. El artículo tiene en cuenta simultáneamente los desarrollos ocurridos en los tres agentes principales del conflicto salvadoreño: la Fuerza Armada, el FMLN y Estados Unidos. En el segundo año de gobierno de ARENA se distinguen cuatro fases en el desarrollo de la guerra, cuyo curso ha estado determinado por el desarrollo de los principales acontecimientos políticos y por el del proceso de diálogo-negociación.
ECA Estudios Centroamericanos, Vol. 46, No. 516, 1991: 891-908.
Dostarlimab (Jemperli)
Authors: CADTH  
Published: November 2022

CADTH reimbursement reviews are comprehensive assessments of the clinical effectiveness and cost-effectiveness, as well as patient and clinician perspectives, of a drug or drug class.
The assessments inform non-binding recommendations that help guide the reimbursement decisions of Canada's federal, provincial, and territorial governments, with the exception of Quebec.
This review assesses dostarlimab (Jemperli), solution for infusion, 500 mg/10 mL vial (50 mg/mL).
Indication: Monotherapy for the treatment of adults with dMMR or MSI-H recurrent or advanced endometrial cancer that has progressed on or after prior treatment with a platinum-containing regimen.
Cariprazine (Vraylar)
Authors: CADTH  
Published: November 2022

CADTH recommends that Vraylar should not be reimbursed by public drug plans for use as monotherapy for the acute management of manic or mixed episodes associated with bipolar I disorder (bipolar mania), and acute management of depressive episodes associated with bipolar I disorder (bipolar depression).
Despite results from 6 clinical trials that showed treatment with Vraylar may improve manic and depressive symptoms associated with bipolar mania and bipolar depression, it is unclear if patients treated with Vraylar in clinical practice would experience the same magnitude of improvement, as patients in the cariprazine studies may not represent the population of patients who will use cariprazine in Canada.
Although the results for the 1.5 mg dose of Vraylar suggested an improvement in depressive symptoms, the results for the 3 mg dose of Vraylar were inconsistent across studies; therefore, the CADTH Canadian Drug Expert Committee (CDEC) was not confident that Vraylar would fill a treatment gap.
The potential benefit of Vraylar compared to other treatments for bipolar I disorder are unknown. There were no studies directly comparing Vraylar with any other treatments, and the indirect comparative evidence reviewed had many limitations.
The dynamics of meaning in the trap of algorithms
Authors: Лешкевич Татьяна Геннадьевна 
Published: November 2022

Рассматриваются сдвиги процесса смыслообразования в контексте цифровой реальности. Фиксируются пять дигитальных ловушек. Первая обусловлена конвергенцией, объединяющей субъектность с возможностями Сети. Вторая связана с феноменом доверия цифровым алгоритмам. Третьей ловушкой выступает Инет-язык, когда смыслосферой современников завладевает дискурс компьютерных команд, дигитальная лексика, обедняющая полифонию смыслообразования. Четвертая - ловушка гиперссылочности, принуждающая в поисках конкретной информации перескакивать на предлагаемый спектр других тем и сюжетов. Пятой когнитивной ловушкой является то, что беглый просмотр сетевого информационного контента не обеспечивает его автоматического превращения в личностное знание, необходимое для самореализации человека.
The article discusses the shifts in the process of meaning formation in the context of digital reality. Five digital traps are pointed out. The first one is connected with convergence, which unites the subjectivity and the possibilities of the Network. The second is related to the phenomenon of trust in digital algorithms. The third trap is the Internet language, when the discourse of computer commands, i.e. digital vocabulary, which impoverishes the polyphony of meaning formation, takes over the semantic sphere of contemporaries. The fourth one is the trap of hyperlinking, forcing to jump to the proposed range of other topics and plots in search of specific information. The fifth cognitive trap is that a cursory view of online information content does not ensure its automatic transformation into personal knowledge necessary for a person’s self-realization.
MODEL PERUBAHAN PERILAKU MASYARAKAT DALAM MENGELOLA MANAJEMEN LINGKUNGAN PADA MASA PANDEMI COVID-19 MODEL PERUBAHAN PERILAKU MASYARAKAT DALAM MENGELOLA MANAJEMEN LINGKUNGAN PADA MASA PANDEMI COVID-19
Authors: Darmo M Pujo , Ratnanik Ratnanik , Luklukaningsih Zuyina , Haris Abdul , Jati Agung Nugroho , Setyawanti Dandang , Nugroho Arif Julianto Sri 
Published: November 2022

Riset ini bertujuan menguji model apakah terdapat pengaruh pengetahuan, sikap, perilaku terhadap perubahan hidup sehat warga Desa Kahuman Polanharjo Klaten. Model yang digunakan menggunakan uji Stuctural Equation Model. Disain riset dilakukan melalui metode kuantitatif. Populasi riset semua warga Kahuman yang telah memahami konsep Perilaku Hidup Bersih Sehat. Teknik sampling pada responden dilakukan secara purposive sampling pada 120 warga Kahuman. Hasil uji diperoleh simpulan dari tiga peubah bebas didapat dua peubah bebas berpengaruh signifikan terhadap PHBS. Sedangkan satu peubah bebas berupa pengetahuan tidak memengaruhi perilaku hidup bersih sehat. Temuan riset memberikan saran kepada pihak pemangku kepentingan terutama perangkat desa, pimpinan satgas Covid tingkat RT RW dan Desa untuk semakin meningkatkan perilaku hidup bersih sehat serta dilakukan riset eksperimen
Evaluasi Sistem Pengadaan Terkait Ketersediaan Obat Di Puskesmas Wilayah Kota Bengkulu
Authors: Muslim Zamharira , Laksono Heru 
Published: November 2022

Puskesmas yang menjadi salah satu tempat pelayanan kesehatan pertama. Untuk menjamin pelanyanan kesehatan yang baik di Puskesmas maka ketersediaan logistik kesehatan salah satunya obat harus dapat dijamin. Tujuan penelitian ini adalah untuk mengevaluasi dan menganalisa permasalahan terkait kondisi ketersediaan logistik obat di Puskesmas pada wilayah Kota Bengkulu. Penelitian ini menggunakan metode pendekatan kualitatif dengan wawancara mendalam dan survei sebagai cara untuk mengumpulkan data. Data yang digunakan adalah voice recorder dan dokumen laporan ketersediaan obat di puskesmas. Informan penelitian ini sebanyak 14 orang yang terdiri dari Dinas Kesehatan Kota Bengkulu, Plh Kepala UPTD Farmasi Dinkes Kota Bengkulu, Apoteker/Staf penanggung jawab farmasi di Puskesmas. Hasil penelitian menunjukkan bahwa ketersediaan obat di Puskesmas wilayah Kota Bengkulu belum sesuai dengan kebutuhan puskesmas. Rata-rata persentase ketersediaan obat di Puskesmas mencapai 97% dan telah melampaui target yang ditetapkan oleh pemerintah yaitu 95%, akan tetapi yang terjadi di lapangan adalah pemenuhan pelayanan kesehatan yang berkaitan dengan obat tidak mencukupi. Pengadaan obat belum sesuai dengan LPLPO yang dibutuhkan oleh puskesmas. Disarankan Kementerian Kesehatan terkhususnya Ditjen Kefarmasian dan Alat Kesehatan melakukan evaluasi kembali dalam penggunaan Formulir Ketersediaan Obat di Puskesmas sebagai instrumen dalam penetapan sasaran kinerja.
Hubungan Kepatuhan Minum Obat dengan Munculnya Gejala Neuropati Pada Pasien Diabetes Melitus Tipe 2 Di Puskesmas Andalas
Authors: Ramadona Auliza , Rustam Erlina , Syauqie Muhammad 
Published: November 2022

Diabetes melitus merupakan suatu kelainan metabolik dengan karakteristik hiperglikemia kronik yang terjadi akibat adanya gangguan pada sekresi insulin, kerja insulin, atau keduanya. Komplikasi yang paling sering terjadi adalah neuropati diabetikum. Salah satu faktor yang dapat mencegah dan menghambat progesifitas neuropati diabetikum adalah kepatuhan pasien dalam minum obat. Penelitian ini bertujuan untuk mengetahui hubungan kepatuhan minum obat dengan munculnya gejala neuropati pada pasien diabetes melitus tipe 2 di Puskesmas Andalas Padang. Penelitian ini merupakan penelitian analitik dengan desain cross-sectional dan metode consecutive sampling. Responden penelitian ini sebanyak 48 orang terpilih sesuai kriteria. Tingkat kepatuhan diukur dengan menggunakan kuesioner Morisky Medication Adherence Scale (MMAS-8) dan gejala neuropati diukur dengan kuesioner Diabetic Neuropathy Symptom (DNS). Uji Chi-square dilakukan untuk mengetahui hubungan keduanya. Didapatkan hasil p = 0,001 (p < 0,05) dengan kesimpulan berupa terdapatnya hubungan antara tingkat kepatuhan minum obat dengan munculnya gejala neuropati pada pasien diabetes melitus tipe 2 di Puskesmas Andalas Padang.