bluuebunny/crossref_metadata_2025_split huggingface dataset:
ANALISIS PROSES BISNIS KENAIKAN PANGKAT PADA DINAS PERTANIAN, PERKEBUNAN DAN KETAHANAN PANGAN KABUPATEN BONE BOLANGO
Authors: Lamusu Rizal 
Published: October 2022

In the process of filing the promotion of civil servants at the Office of Argriculture. Plantation and Food Security Bone Bolango regency experienced the problems because the data or file civil servants are not stored in the field officials in Agriculture, Plantation and Food Security, Bone Bolango regency and data collection on the promotion of civil servants still do manually or conventional so takes long time. This research aims to simplify and accelerate the process of conducted with using the Research and Development (R and D) as well as development of systems using Bussiness Process Model Natotation (BPMN). The result in this reserach showed gaps and opportunities for increase the business process in the Office of Agriculture, Plantation and Food Security in Bone Bolango regenvy that includes major activities and supporting activity. This research can be developed in the form of base web, mobile web, and security system.
Prevalence and Associated Factors of Caries and Periodontal Diseases among Adolescents in Kunming: A Cross-sectional Study
Authors: Xu Jie , Naorungroj Supawadee , Pahumunto Nuntiya , Teanpaisan Rawee 
Published: October 2022

Objective: To investigate the prevalence of dental caries, and periodontal diseases among adolescents in urban high schools of Kunming and associated factors. Material and Methods: This cross-sectional survey enrolled 560 adolescents (17.3±0.5 years old), with an equal gender ratio. Self-administered questionnaires obtained the sociodemographic and behavioral variables. All subjects were examined for their clinical parameters; including, Decayed, Missing, and Filled Teeth (DMFT), the Simplified Oral Hygiene Index (OHI-S), bleeding on probing (BOP), probing depth (PD) and clinical attachment level (CAL) by two dentists. The correlations of explanatory variables with dental caries and periodontal disease outcomes were investigated using bivariate analysis; via chi-square and t-test. Multivariate regression analysis; including linear regression and logistic regression models, were investigated for related factors of dental caries and periodontal diseases. Results: The prevalence of caries was 72.5%, with a mean DMFT of 3.70±3.65. The DMFT of females was higher than males (p-value<0.001); approximately 12.3% were periodontal healthy. The prevalence of gingivitis and periodontitis was 80.4% and 7.3%, respectively; with no statistical difference between genders (p-value=0.221). Multivariate regression analysis showed that the prevalence of dental caries and periodontal diseases were associated with females and fair/ poor oral hygiene. Additionally, high sugar consumption was a significant risk predictor for dental caries (p-value=0.008). Conclusion: The high prevalence of dental caries and periodontal disease in Kunming urban high school adolescents were associated with females and oral hygiene. Therefore, it is necessary for them to pay more attention to their oral health, and to focus on improving the efficiency of oral hygiene behavior.
Seizure outcome after resection of insular glioma: a systematic review, meta-analysis, and institutional experience
Authors: Zhang John J. Y. , Lee Keng Siang , Wang Doris D. , Hervey-Jumper Shawn L. , Berger Mitchel S. 
Published: October 2022

OBJECTIVE
Gliomas arising from the insular cortex can be epileptogenic, with a significant proportion of patients having medically refractory epilepsy. The impact of surgery on seizure control for such tumors is not well established. In this study, the authors aimed to investigate seizure outcomes after resection of insular gliomas using a meta-analysis and institutional experience.

METHODS
Three databases (Ovid MEDLINE, Embase, and Cochrane Central Register of Controlled Trials) were systematically searched for published studies of seizure outcomes after insular glioma resection from database inception to March 27, 2021. In addition, data were retrospectively collected on all adults (age > 17 years) who had undergone insular glioma resection between June 1997 and June 2015 at the authors’ institution. Primary outcome measures were seizure freedom rates at 1 year and the last follow-up. Secondary outcome measures consisted of persistent postoperative neurological deficit beyond 90 days, mortality, and tumor progression or recurrence.

RESULTS
Eight studies reporting on 453 patients who had undergone 460 operations were included in the meta-analysis. The pooled mean age of the patients was 42 years. The pooled percentages of patients with extents of resection (EORs) ≥ 90%, 70%–89%, and < 70% were 55%, 33%, and 11%, respectively. The pooled seizure freedom rate at 1 year was 73% for Engel class IA and 78% for Engel class I. The pooled seizure freedom rate at the last follow-up was 60% for Engel class IA and 79% for Engel class I. The pooled percentage of persistent neurological deficit beyond 90 days was 3%. At the authors’ institution, 109 patients had undergone resection of insular glioma. A greater EOR was the only significant independent predictor of seizure freedom after surgery (HR 0.290, p = 0.017). The optimal threshold for seizure freedom corresponded to an EOR of 81%. Patients with an EOR > 81% had a significantly higher seizure freedom rate (OR 2.16, p = 0.048).

CONCLUSIONS
Maximal safe resection can be performed with minimal surgical morbidity to achieve favorable seizure freedom rates in both the short and long term. When gross-total resection is not possible, an EOR > 81% confers the greatest sensitivity and specificity for achieving seizure freedom.
Systematic review registration no.: CRD42021249404 (https://www.crd.york.ac.uk/prospero/)
Surgery for glioblastomas in the elderly: an Association des Neuro-oncologues d’Expression Française (ANOCEF) trial
Authors: Laigle-Donadey Florence , Metellus Philippe , Guyotat Jacques , Menei Philippe , Proust François , Dufour Henry , Chinot Olivier , Honnorat Jérôme , Faillot Thierry , Paquis Philippe , Peruzzi Philippe , Emery Evelyne , Guillamo Jean-Sébastien , Carpentier Alexandre , Wager Michel , Lebbah Said , Hajage David , Delattre Jean-Yves , Cornu Philippe 
Published: October 2022

OBJECTIVE
The role of surgery in the treatment of malignant gliomas in the elderly is not settled. The authors conducted a randomized trial that compared tumor resection with biopsy only—both followed by standard therapy—in such patients.

METHODS
Patients ≥ 70 years of age with a Karnofsky Performance Scale (KPS) score ≥ 50 and presenting with a radiological suspicion of operable glioblastoma (GBM) were randomly assigned between tumor resection and biopsy groups. Subsequently, they underwent standard radiotherapy during the first years of the trial (2008–2017), with the addition of adjunct therapy with temozolomide when this regimen became standard (2017–2019). The primary endpoint was survival, and secondary endpoints were progression-free survival (PFS), cognitive status (Mini-Mental State Examination), autonomy (KPS), quality of life (European Organisation for Research and Treatment of Cancer [EORTC] QLQ-C30 and QLQ-BN20), and perioperative morbidity and mortality.

RESULTS
Between 2008 and 2019, 107 patients from 9 centers were enrolled in the study; 101 were evaluable for analysis because a GBM was histologically confirmed (50 in the surgery arm and 51 in the biopsy arm). There was no statistically significant difference in median survival between the surgery (9.37 months) and the biopsy (8.96 months, p = 0.36) arms (adjusted HR 0.79, 95% CI 0.52–1.21, p = 0.28). However, the surgery group had an increased PFS (5.06 vs 4.02 months; p = 0.034) (adjusted HR 0.50, 95% CI 0.32–0.78, p = 0.002). Less deterioration of quality of life and KPS score evolution than in the biopsy group was observed. Surgery was not associated with increased mortality or morbidity.

CONCLUSIONS
This study suggests that debulking surgery is safe, and—compared to biopsy—is associated with a less severe deterioration of quality of life and autonomy, as well as a significant although modest improvement of PFS in elderly patients suffering from newly diagnosed malignant glioma. Although resection does not provide a significant survival benefit in the elderly, the authors believe that the risk/benefit analysis favors an attempt at optimal tumor resection in this population, provided there is careful preoperative geriatric evaluation.
Clinical trial registration no.: NCT02892708 (ClinicalTrials.gov)
Management strategies in clival and craniovertebral junction chordomas: a 29-year experience
Authors: Passeri Thibault , Champagne Pierre-Olivier , Giammattei Lorenzo , Abbritti Rosaria , Cartailler Jérôme , Calugaru Valentin , Feuvret Loïc , Guichard Jean-Pierre , Polivka Marc , Adle-Biassette Homa , Mammar Hamid , Bresson Damien , Herman Philippe , Mandonnet Emmanuel , George Bernard , Froelich Sébastien 
Published: October 2022

OBJECTIVE
Chordomas represent one of the most challenging subsets of skull base and craniovertebral junction (CVJ) tumors to treat. Despite extensive resection followed by proton-beam radiation therapy, the recurrence rate remains high, highlighting the importance of developing efficient treatment strategies. In this study, the authors present their experience in treating clival and CVJ chordomas over a 29-year period.

METHODS
The authors conducted a retrospective study of clival and CVJ chordomas that were surgically treated at their institution from 1991 to 2020. This study focuses on three aspects of the management of these tumors: the factors influencing the extent of resection (EOR), the predictors of survival, and the outcomes of the endoscopic endonasal approaches (EEAs) compared with open approaches (OAs).

RESULTS
A total of 265 surgical procedures were performed in 210 patients, including 123 OAs (46.4%) and 142 EEAs (53.6%). Tumors that had an intradural extension (p = 0.03), brainstem contact (p = 0.005), cavernous sinus extension (p = 0.004), major artery encasement (p = 0.01), petrous apex extension (p = 0.003), or high volume (p = 0.0003) were significantly associated with a lower EOR. The 5-year progression-free survival (PFS) and overall survival (OS) rates were 52.1% and 75.1%, respectively. Gross-total resection and Ki-67 labeling index < 6% were considered to be independent prognostic factors of longer PFS (p = 0.0005 and p = 0.003, respectively) and OS (p = 0.02 and p = 0.03, respectively). Postoperative radiation therapy correlated independently with a longer PFS (p = 0.006). Previous surgical treatment was associated with a lower EOR (p = 0.01) and a higher rate of CSF leakage after EEAs (p = 0.02) but did not have significantly lower PFS and OS compared with primary surgery. Previously radiation therapy correlated with a worse outcome, with lower PFS and OS (p = 0.001 and p = 0.007, respectively). EEAs were more frequently used in patients with upper and middle clival tumors (p = 0.002 and p < 0.0001, respectively), had a better rate of EOR (p = 0.003), and had a lower risk of de novo neurological deficit (p < 0.0001) compared with OAs. The overall rate of postoperative CSF leakage after EEAs was 14.8%.

CONCLUSIONS
This large study showed that gross-total resection should be attempted in a multidisciplinary skull base center before providing radiation therapy. EEAs should be considered as the gold-standard approach for upper/middle clival lesions based on the satisfactory surgical outcome, but OAs remain important tools for large complex chordomas.
Short- and long-term outcomes of moyamoya patients post-revascularization
Authors: Teo Mario , Abhinav Kumar , Bell-Stephens Teresa E. , Madhugiri Venkatesh S. , Sussman Eric S. , Azad Tej Deepak , Ali Rohaid , Esparza Rogelio , Zhang Michael , Steinberg Gary K. 
Published: October 2022

OBJECTIVE
The post-bypass stroke risk factors and long-term outcomes of moyamoya patients are not well documented. Therefore, the authors studied 30-day stroke risks and patients’ long-term physical, functional, and social well-being.

METHODS
This was a single-institution combined moyamoya disease (MMD) database interrogation and questionnaire study. From 1991 to 2014, 1250 revascularization procedures (1118 direct bypasses, 132 indirect bypasses) were performed in 769 patients. Completed questionnaires were received from and available for analysis on 391 patients, and 6-month follow-up data were available for 96.4% (741/769) of the patients.

RESULTS
The patients consisted of 548 females and 221 males, with a mean age of 32 years (range 1–69 years). Three hundred fifty-eight bypasses were performed in 205 pediatric patients (73% direct bypasses), and 892 revascularizations were performed in 564 adults (96% direct bypasses). Fifty-two patients (6.8%) developed major strokes with a worsening modified Rankin Scale (mRS) score within 30 days postoperatively. The 30-day major stroke risk was 5.3% (41/769) and 2.6% (12/467) after the first and second bypasses, respectively. Logistic regression analysis revealed that older age, modified MRI (mMRI) score, and hemodynamic reserve (HDR) score are clearly associated with higher postoperative stroke risks. Over a mean follow-up of 7.3 years (range 0.5–26 years), the long-term stroke risk among 741 patients was 0.6% per patient-year; 75% of these patients had excellent outcomes (mRS score 0–1). The long-term outcome questionnaire study showed that 84% (234/277) of patients reported resolution or improvement in their preoperative headache, 83% (325/391) remained employed or in school, and 87% (303/348) were self-caring.

CONCLUSIONS
In this large, single-center surgical series, most of the adult and pediatric patients had direct revascularization, with a 4.2% per-bypass-procedure (6.8% per patient) 30-day major stroke risk and a 0.6% per-patient-year long-term stroke risk. The authors identified various risk factors that are highly correlated with postoperative morbidity (age, mMRI score, and HDR score) and are involved in ongoing work to develop the predictive modeling for future patient selection and treatment.
Predicting leptomeningeal disease spread after resection of brain metastases using machine learning
Authors: Tewarie Ishaan Ashwini , Senko Alexander W. , Jessurun Charissa A. C. , Zhang Abigail Tianai , Hulsbergen Alexander F. C. , Rendon Luis , McNulty Jack , Broekman Marike L. D. , Peng Luke C. , Smith Timothy R. , Phillips John G. 
Published: October 2022

OBJECTIVE
The incidence of leptomeningeal disease (LMD) has increased as treatments for brain metastases (BMs) have improved and patients with metastatic disease are living longer. Sample sizes of individual studies investigating LMD after surgery for BMs and its risk factors have been limited, ranging from 200 to 400 patients at risk for LMD, which only allows the use of conventional biostatistics. Here, the authors used machine learning techniques to enhance LMD prediction in a cohort of surgically treated BMs.

METHODS
A conditional survival forest, a Cox proportional hazards model, an extreme gradient boosting (XGBoost) classifier, an extra trees classifier, and logistic regression were trained. A synthetic minority oversampling technique (SMOTE) was used to train the models and handle the inherent class imbalance. Patients were divided into an 80:20 training and test set. Fivefold cross-validation was used on the training set for hyperparameter optimization. Patients eligible for study inclusion were adults who had consecutively undergone neurosurgical BM treatment, had been admitted to Brigham and Women’s Hospital from January 2007 through December 2019, and had a minimum of 1 month of follow-up after neurosurgical treatment.

RESULTS
A total of 1054 surgically treated BM patients were included in this analysis. LMD occurred in 168 patients (15.9%) at a median of 7.05 months after BM diagnosis. The discrimination of LMD occurrence was optimal using an XGboost algorithm (area under the curve = 0.83), and the time to LMD was prognosticated evenly by the random forest algorithm and the Cox proportional hazards model (C-index = 0.76). The most important feature for both LMD classification and regression was the BM proximity to the CSF space, followed by a cerebellar BM location. Lymph node metastasis of the primary tumor at BM diagnosis and a cerebellar BM location were the strongest risk factors for both LMD occurrence and time to LMD.

CONCLUSIONS
The outcomes of LMD patients in the BM population are predictable using SMOTE and machine learning. Lymph node metastasis of the primary tumor at BM diagnosis and a cerebellar BM location were the strongest LMD risk factors.
Is intracranial electroencephalography mandatory for MRI-negative neocortical epilepsy surgery?
Authors: Guo Zhihao , Zhang Chao , Wang Xiu , Liu Chang , Zhao Baotian , Mo Jiajie , Zheng Zhong , Shao Xiaoqiu , Zhang Jianguo , Zhang Kai , Hu Wenhan 
Published: October 2022

OBJECTIVE
MRI-negative focal epilepsy is one of the most challenging cases in surgical epilepsy treatment. Many epilepsy centers recommend intracranial electroencephalography (EEG) for MRI-negative cases, especially neocortical epilepsy. This retrospective study aimed to explore whether intracranial monitoring is mandatory in MRI-negative neocortical epilepsy surgery and the factors that significantly influence the decision on whether to perform intracranial recording.

METHODS
In this study, consecutive surgical patients with focal MRI-negative neocortical epilepsy were recruited. All patients underwent routine preoperative evaluation according to the dedicated protocol of the authors’ epilepsy center to determine the treatment strategy. Patients were divided into two groups according to the surgical strategy, i.e., a direct group and a stereo-EEG (SEEG)–guided group. History of epilepsy, seizure frequency, interictal and ictal EEG data, PET data, PET/MRI coregistration data, neuropathological findings, and surgical outcomes were compared between the two groups. Multivariate analysis was performed to identify factors influencing the decision to perform SEEG monitoring.

RESULTS
Sixty-four patients were included in this study, 19 and 45 of whom underwent direct and SEEG-guided cortical resection, respectively. At an average follow-up of 3.9 years postoperatively, 56 patients (87.5%) had Engel class I results without permanent neurological deficits. Surgical outcomes were not significantly different between the direct and SEEG-guided groups (94.7% vs 84.4%). PET hypometabolic abnormalities were detected in all patients. There were significant differences between the two groups in the extent of hypometabolism (focal vs nonfocal, p < 0.01) and pathological subtype (focal cortical dysplasia type II vs others, p = 0.03). Multivariate analysis revealed that the extent of hypometabolism (OR 0.01, 95% CI 0.00–0.15; p = 0.001) was the only independent factor affecting the treatment strategy.

CONCLUSIONS
Careful selection of patients with MRI-negative neocortical epilepsy may yield favorable outcomes after direct cortical resection without intracranial monitoring. PET/MRI coregistration plays an essential role in the preoperative evaluation and subsequent resection of these patients. Intracranial monitoring is not a mandatory requirement for surgery if the focal hypometabolic areas are consistent with the findings of semiology and scalp EEG.
Spinal injuries after ejection seat evacuation in fighter aircraft of the German Armed Forces between 1975 and 2021
Authors: Sommer Fabian , Gadjradj Pravesh Shankar , Pippig Torsten 
Published: October 2022

OBJECTIVE
The ejection seat is one of the most important rescue tools for military aircrews. However, the high ejection speeds place high loads on the pilots, which is mainly absorbed by the pilot’s spine. The differentiated evaluation of spinal injuries is of particular importance because this has a decisive influence on the further personal life and career of the affected aircrew members. Factors influencing the occurrence of a fracture as well as the impact of a spinal injury on military flight certification have not been addressed sufficiently to date.

METHODS
The authors conducted a retrospective evaluation of ejection seat evacuations in German Armed Forces combat aircraft accidents between 1975 and 2021. The total number of aviation accidents with ejection seat initiations and the survived ejections were collected. Accident-specific data and pilot-specific data were collected. In addition, it was evaluated whether aircrew members were recertified for military flight after the accident. The type of spinal injury and the location of the injury were evaluated. In addition to the descriptive statistics, two logistic regression models were developed to assess prediction values of accident- and pilot-specific factors for spine injuries.

RESULTS
A total of 103 aircrew members were included in this retrospective analysis. The overall prevalence of spine injuries was 56.3%, and the overall prevalence of spine fractures was 33.0%. In the first regression model analysis, there was no association with pilot flight experience, age, height, weight, BMI, and being diagnosed with a spine fracture. Similarly, aircraft type, altitude, and airspeed were not associated with the occurrence of spine fractures. In the regression model analysis for predictors of rejection in military flight recertification after ejection seat evacuation, lumbar spine fractures were associated with higher odds of being rejected for recertification.

CONCLUSIONS
Military aircraft crew members have a high risk of suffering from a spine injury after emergency evacuation using an ejection seat. In the subsequent medical workup, special attention should be paid to the spine, and ideally a consultation with a spine surgeon should be performed. Lumbar spine fractures may have major consequences for military flight certification, and therefore special attention should be paid to successful rehabilitation.