bluuebunny/crossref_metadata_2025_split huggingface dataset:
Professional development and career planning for nurses working in care homes for older people: A scoping review
Authors: Fitzpatrick Joanne M. , Bianchi Leda A. , Hayes Nicky , Da Silva Tiago , Harris Ruth 
Published: November 2022

AbstractBackgroundA skilled, knowledgeable, and compassionate nurse workforce is pivotal to caring well for older people living in care homes. This requires the provision of continuing professional development and career planning for nurses, which are key also for nurse recruitment and retention. Continuing professional development and career planning strategies and interventions should be evidence‐driven.ObjectiveTo identify the extent, range and nature of contemporary evidence regarding professional development and career planning for nurses caring for older people living in care homes.MethodsThe methodological framework used was the Joanna Briggs Institute guidance for scoping reviews. The PRISMA extension for scoping reviews was used as the reporting framework. Four databases were searched from January 2010 to July 2021. Results were screened independently by two reviewers using eligibility criteria. Full texts and the reference lists of eligible articles were reviewed. Data were extracted for key elements from the 25 articles included.ResultsOf the 25 articles, the majority were authored in the United States (n = 10) and UK (n = 8) with the remaining from Australia (n = 3), Canada (n = 3) and the Netherlands (n = 1). Four articles reported on professional development programmes. Three literature reviews addressed challenges for nurse participation in professional development, experiences of care home nurses as clinical leaders and managers, and leadership. Two expert commentaries reported on the challenges related to professional development and career planning for care home nurses. Sixteen empirical studies investigated a range of topics including: competencies, roles, intention to stay and leave, continuing professional development, and leadership. Key emergent factors that support professional development and career planning were as follows: access to structured learning opportunities addressing knowledge and skills specific to nursing frail older adults, a supportive working environment including adequate staffing, study time and flexible working, and integration of leadership development.Conclusions and implications for practiceThis scoping review has highlighted factors that support and challenge professional development and career planning for nurses working in the care home sector. There remain important gaps in the opportunities for professional development and career planning for care home nurses that warrant attention.
Outcomes in Patients with Global Pincer Versus Focal Pincer Femoroacetabular Impingement Treated with Hip Arthroscopy: A Retrospective Study with a Minimum 2‐Year Follow‐Up
Authors: Shao Jia‐Yi , He Zi‐Yi , Xu Yan , Dai Ling‐Hui , Wang Jian‐quan , Ju Xiao‐Dong 
Published: November 2022

ObjectiveGlobal pincer is a relatively rare form of pincer deformity and is typically associated with technical challenges during surgery. So far, controversy remains whether patients with global pincer have equivalent surgical outcomes compared to patients with focal pincer. This study compares the clinical outcomes of arthroscopic treatment between patients with global pincer femoroacetabular impingement (FAI) and focal pincer FAI in the Chinese population.MethodsData were retrospectively collected from patients with global and focal pincer FAI who underwent hip arthroscopy with a minimum two‐year follow‐up between April 2016 and December 2018. Radiographic measurements, arthroscopic procedures, preoperative and postoperative patient‐reported outcomes (PROs) including modified Harris hip score (mHHS), hip outcome score‐activities of daily living (HOS‐ADL), international hip outcome tool–12 (iHOT‐12), and visual analogue scale (VAS) scores, rates of revision surgery and conversion to total hip arthroplasty (THA) were recorded. Achievement of minimal clinically important difference (MCID) and patient acceptable symptomatic state (PASS) was compared for the VAS, mHHS, HOS‐ADL, and iHOT‐12 scores between groups.ResultsThe total of 33 and 167 patients were included in the global and focal group, respectively. There were no intergroup differences in age, gender, body mass index or follow‐up times. Lateral center‐edge angle (LCEA) was reduced in both groups postoperatively. Both groups demonstrated significant improvements in PROs compared with preoperative levels at the final follow‐up. The preoperative scores showed significant differences in terms of mHHS (60.34 vs 62.90, P = 0.031) and HOS‐ADL (61.45 vs 64.74, P = 0.022) scores between two groups, and the improvement of HOS‐ADL score was significantly higher in global group (P = 0.027). However, the postoperative scores, including VAS, mHHS, HOS‐ADL, and iHOT‐12 scores, showed no significant differences between two groups. And there were no significant differences in the rate of meeting the PASS and MCID between groups. One (3.0%) in the global group and six (3.6%) patients in the focal group underwent revision arthroscopy respectively, with no significant difference (P = 0.876). There were no conversions to THA in both groups.ConclusionsArthroscopic management of global pincer FAI can achieve excellent functional scores at minimum 2‐year follow‐up. The outcomes were similar to focal pincer FAI patients with a low rate of secondary procedure.
Chronic kidney disease is associated with increased all‐cause mortality in transvenous lead extraction: A systematic review and meta‐analysis
Authors: Tan Min Choon , Talaei Fahimeh , Trongtorsak Angkawipa , Lee Justin Z. , Rattanawong Pattara 
Published: November 2022

AbstractBackgroundThe impact of chronic kidney disease (CKD) or end‐stage renal disease (ESRD) on patients receiving transvenous lead extraction (TLE) is not well‐established. We performed a systematic review and meta‐analysis to explore the association between CKD and all‐cause mortality in TLE.MethodsWe searched the databases of PubMed and EMBASE from inception to April 2022. Included studies were published TLE studies that compared the risk of mortality in CKD patients compared to control patients. Data from each study were combined using the random‐effects model.ResultsEight studies (5,013 patients) were included. Compared with controls, CKD patients had a significantly higher risk of overall all‐cause mortality (hazard ratio [HR] = 2.14, 95% confidence interval [CI]: 1.65–2.77, I2 = 51.1%, p < .001). The risk of overall all‐cause mortality increased with the severity of CKD for nonspecific CKD (HR = 2.01, 95% CI: 1.49–2.69, I2 = 53.4, p < .001) and ESRD (HR = 2.79, 95% CI: 1.85–4.23, I2 = 0%, p < .001). The risk of all‐cause mortality in CKD is double at follow‐up ≤1 year (HR = 1.99, 95% CI: 1.29–3.09, I2 = 50.9%, p = .002) and higher at follow‐up >1 year (HR = 2.36, 95% CI: 1.63–3.42, I2 = 59.7%, p < .001).ConclusionsOur meta‐analysis demonstrates a significantly increased risk of overall all‐cause mortality in patients with CKD who underwent TLE compared to controls.
980 nm Photobiomodulation Promotes Osteo/Odontogenic Differentiation of the Stem Cells from Human Exfoliated Deciduous Teeth Via the Cross talk Between BMP/Smad and Wnt/β‐Catenin Signaling Pathways
Authors: Wang Ziting , Tian Tian , Chen Leyi , Zhang Chuhan , Zheng Xiao , Zhong Ni , Wu Buling , Xu Wen'an 
Published: November 2022

AbstractIncreasing evidence suggests stem cells from human exfoliated deciduous teeth (SHEDs) serve as desirable sources of dentin regeneration. Photobiomodulation (PBM) has shown great potential in enhancing the proliferation and osteogenesis of human bone marrow mesenchymal stem cells (hBMMSCs). However, the specific role of PBM in odontogenic differentiation of SHEDs is little know, and we further investigated potential mechanism of PBM osteo/odontogenisis. A 980 nm diode laser with different energy densities of (0.5, 5, 10 J cm−2) in a 100‐mW continuous wave was used for irradiation every 24 h. Osteo/odontogenic differentiation of SHEDs was achieved by performing alkaline phosphatase (ALP) and alizarin red staining (ARS) and osteo/odontogenic markers were also evaluated by qRT‐PCR and western blotting. Additionally, western blot and immunohistochemical staining were performed to evaluate the levels of BMP/Smad and Wnt/β‐catenin signaling‐related proteins. We found that PBM at 5 J cm−1 increased mineral deposition and upregulated the expression of related osteo/odontogenic markers along with the elevated expression of β‐catenin and phosphorylation level of Smad1/5/9. Furthermore, Wnt signaling inhibition using DKK1 and BMP signaling inhibition using noggin inhibited PBM‐induced osteo/odontogenic marker expression when used individually or jointly. In conclusion, PBM induces the osteo/odontogenic differentiation of SHEDs through cross talk between BMP/Smad and Wnt/β‐catenin signaling pathways.
Alternate wetting and drying modulated physio‐biochemical attributes, grain yield, quality, and aroma volatile in fragrant rice
Authors: Ashraf Umair , Hussain Saddam , Naveed Shahid Muhammad , Anjum Shakeel Ahmad , Kondo Motohiko , Mo Zhaowen , Tang Xiangru 
Published: November 2022

AbstractAlternate wetting and drying (AWD) has been recognized as a water‐saving technology in rice production systems; however, pre‐ and post‐flowering AWD could induce changes in yield, quality and aroma biosynthesis in fragrant rice. In the present study, two fragrant rice cultivars (Guixiangzhan and Nongxiang‐18) were subjected to AWD till soil water potential reached −25 to −30 kPa during vegetative stage (VS), reproductive stage (RS), and both stages (VS + RS). The AWD did not affect net photosynthesis and gas exchange significantly, while malondialdehyde (MDA), H2O2 and electrolyte leakage (EL) were higher than in control plants. The AWD treatments variably affected soluble sugars, proline and protein accumulation as well as the activities of superoxide dismutase (SOD), peroxidase (POD), catalase (CAT), ascorbate peroxidase (APX), and reduced glutathione (GSH) contents. Moreover, filled grain percentage and 1000‐grain weight in AWD treatments were found to be statistically similar (p > 0.05) to control, except grains panicle−1 under AWD‐VS + RS that was reduced by 11% and 14% for Guixiangzhan and Nongxiang‐18, respectively. On average, yield and related attributes in Guixiangzhan remained higher than in Nongxiang‐18. In addition, the grain aroma volatile (2‐acetyl‐1‐pyrroline, 2‐AP) content increased by 8.79%, 14.45%, and 6.87% and 7.95%, 14.02%, and 5.04% under AWD‐VS, AWD‐RS, and AWD‐VS + RS treatments, for Guixiangzhan and Nongxiang‐18, respectively. Overall, AWD treatments, either at VS or RS, could promote rice aroma in terms of accumulation of 2AP, which might be linked with enhanced endogenous proline contents (a precursor for 2AP biosynthesis) without any severe consequences on rice yield and quality.
The PavNAC56 transcription factor positively regulates fruit ripening and softening in sweet cherry (Prunus avium)
Authors: Qi Xiliang , Dong Yuanxin , Liu Congli , Song Lulu , Chen Lei , Li Ming 
Published: November 2022

AbstractThe rapid softening of sweet cherry fruits during ripening results in the deterioration of fruit quality. However, few genes related to sweet cherry fruit ripening and softening have been identified, and the molecular regulatory mechanisms underlying this process are poorly understood. Here, we identified and functionally characterized PavNAC56, a NAC transcription factor that positively regulates sweet cherry fruit ripening and softening. Gene expression analyses showed that PavNAC56 was specifically and abundantly expressed in the fruit, and its transcript levels increased in response to abscisic acid (ABA). A subcellular localization analysis revealed that PavNAC56 is a nucleus‐localized protein. Virus‐induced gene silencing of PavNAC56 inhibited fruit ripening, enhanced fruit firmness, decreased the contents of ABA, anthocyanins, and soluble solids, and down‐regulated several fruit ripening‐related genes. Yeast one‐hybrid and dual‐luciferase assays showed that PavNAC56 directly binds to the promoters of several genes related to cell wall metabolism (PavPG2, PavEXPA4, PavPL18, and PavCEL8) and activates their expression. Overall, our findings show that PavNAC56 plays an indispensable role in controlling the ripening and softening of sweet cherry fruit and provides new insights into the regulatory mechanisms by which NAC transcription factors affect nonclimacteric fruit ripening and softening.
Prediction and association analyses of skin phenotypes in Japanese females using genetic, environmental, and physical features
Authors: Amano Satoshi , Yoshikawa Tatsuya , Ito Chiaki , Mabuchi Ikumi , Kikuchi Kumiko , Ooguri Motoki , Yasuda Chie 
Published: November 2022

AbstractBackgroundSkin characteristics show great variation from person to person and are affected by multiple factors, including genetic, environmental, and physical factors, but details of the involvement and contributions of these factors remain unclear.ObjectivesWe aimed to characterize genetic, environmental, and physical factors affecting 16 skin features by developing models to predict personal skin characteristics.MethodsWe analyzed the associations of skin phenotypes with genetic, environmental, and physical features in 1472 Japanese females aged 20–80 years. We focused on 16 skin characteristics, including melanin, brightness/lightness, yellowness, pigmented spots, wrinkles, resilience, moisture, barrier function, texture, and sebum amount. As genetic factors, we selected 74 single‐nucleotide polymorphisms of genes related to skin color, vitamin level, hormones, circulation, extracellular matrix (ECM) components and ECM‐degrading enzymes, inflammation, and antioxidants. Histories of ultraviolet (UV) exposure and smoking as environmental factors and age, height, and weight as physical factors were acquired by means of a questionnaire.ResultsA linear association with age was prominent for increase in the area of crow's feet, increase in number of pigmented spots, decrease in forehead sebum, and increase in VISIA wrinkle parameters. Associations were analyzed by constructing linear regression models for skin feature changes and logistic regression models to predict whether subjects show lower or higher skin measurement values in the same age groups. Multiple genetic factors, history of UV exposure and smoking, and body mass index were statistically selected for each skin characteristic. The most important association found for skin spots, such as lentigines and wrinkles, was adolescent sun exposure.ConclusionGenetic, environmental, and physical factors associated with interindividual differences of the selected skin features were identified. The developed models should be useful to predict the skin characteristics of individuals and their age‐related changes.
Comparison of three rebound tonometers in normal and glaucomatous dogs
Authors: Hodgson Kimberly J. , Harman Christine D. , Bajric Shayla , Cabble Ava , Anderson Amanda L. , Palanivel Hemalatha , Taylor David A. , Komáromy András M. 
Published: November 2022

AbstractObjectiveThe objectives of the study were to compare intraocular pressure (IOP) readings across a wide range and obtained via three rebound tonometers in ADAMTS10‐mutant Beagle‐derived dogs with different stages of open‐angle glaucoma (OAG) and normal control dogs and to investigate the effect of central corneal thickness (CCT).Animals StudiedMeasurements were performed on 99 eyes from 50 Beagle‐derived dogs with variable genetics—16 non‐glaucomatous and 34 with ADAMTS10‐OAG. Seventeen OAG eyes were measured twice—with and without the use of IOP‐lowering medications.ProceduresIOP was measured in each eye using three tonometers with their “dog” setting—ICare® Tonovet (TV), ICare® Tonovet Plus® (TVP), and the novel Reichert® Tono‐Vera® Vet (TVA)—in randomized order. CCT was measured with the Accutome® PachPen. Statistical analyses included one‐way ANOVA, Tukey pairwise comparisons, and regression analyses of tonometer readings and pairwise IOP‐CCT Pearson correlations (MiniTab®).ResultsA total of 116 IOP measurements were taken with each of the three tonometers. When comparing readings over a range of ~7–77 mmHg, mean IOPs from the TV were significantly lower compared with TVP (−4.6 mmHg, p < .001) and TVA (−3.7 mmHg, p = .001). We found no significant differences between TVA and TVP measurements (p = .695). There was a moderate positive correlation between CCT and IOP for TVA (r = 0.53, p < .001), TVP (r = 0.48, p < .001), and TV (r = 0.47, p < .001).ConclusionsOur data demonstrate strong agreement between TVP and TVA, suggesting that the TVA may similarly reflect true IOP values in canines. CCT influenced IOP measurements of all three tonometers.
Ecdysis for globalization: ESP in Japan today
Authors: Noguchi Judy 
Published: November 2022

AbstractThe Japanese are often made fun of for their lack of ability to use other languages, especially English. This article will suggest some reasons for this and then go on to describe various efforts being made to improve English education in Japan. One of these has been the application of an ESP (English for specific purposes) approach to the teaching of specific language registers. Various examples are presented to show how ESP concepts can be applied from secondary school to graduate school language education. These efforts should result in an ecdysis that produces Japanese who can use English for specific purposes according to their communicative needs.
First report of knowledge and practices towards toxoplasmosis among cat owners: A cross‐sectional survey in Bangladesh
Authors: Uddin AHM Musleh , Hasan Tanjila , Hossain Delower , Nahar Kamrun , Islam Tauhidul , Islam MD. Tanvir , Saraf Md. Sawkat Hasan , Karim Md Robiul , Atikuzzaman Mohammad , Ahsan Md. Irtija 
Published: November 2022

AbstractRaising awareness about Toxoplasma gondii infection among cat owners in Bangladesh is indispensable to formulate persuasive management tactics to avoid zoonotic infections from pet cats. However, to the authors' best knowledge, no studies have been performed in Bangladesh to determine knowledge and practices of toxoplasmosis in cat owners. Therefore, the objectives of the current study were to cover this research gap. We carried out a cross‐sectional study in Bangladesh from June 2020 through December 2021. A structured online questionnaire was distributed to cat owners, which were voluntarily completed by them. The questionnaire included socio‐demographic data, aetiology, transmissions, clinical signs, and preventive practices towards toxoplasmosis. Overall, 1,019 cat owners participated voluntarily in the cross‐sectional survey. Among them, 793 (77.82%) participants showed poor knowledge regarding toxoplasmosis. Under specific knowledge sections, 62.51% of the participants revealed incorrect knowledge that toxoplasmosis was a zoonotic disease. In the same way, (72.03–85.77) % of the cat owners were unaware that the disease could be transmitted from improperly washed vegetables, raw or undercooked meat and fish, and contaminated water and milk with cat faeces. Respondents' age, education, occupation, residence type, and marital status were significantly (p < .05) associated with their knowledge level. Besides, 94.11% of cat owners had a good practice level. They followed good practices in different issues; however, they practiced those activities without knowing their impacts on disease control. Cat owners' age, education, occupation, and residence type had a significant (p < .05) association with the practice level against toxoplasmosis. This is the first study highlighting the low level of knowledge among cat owners about toxoplasmosis in Bangladesh. These knowledge gaps could increase the risk and transmission of Toxoplasma gondii infection among them and their families. The survey recommends the arrangement of educational training and programmes to increase the awareness of toxoplasmosis among cat owners.
Evaluation of carbohydrate counting knowledge among individuals with type 1 diabetes mellitus in Saudi Arabia: a cross-sectional study
Authors: Bawazeer Nahla Mohammed , Alshehri Leena Hamdan , Alharbi Nouf Mohammed , Alhazmi Noha Abdulaziz , Alrubaysh Alhanouf Fahad , Alkasser Alia Riad , Aburisheh Khaled Hani 
Published: November 2022

IntroductionCarbohydrate counting (CC) is an important nutritional strategy to improve glycaemic outcomes among patients with diabetes. Few studies have investigated CC knowledge among individuals with type 1 diabetes mellitus (T1DM) in Saudi Arabia. Therefore, we aimed to evaluate CC knowledge in Saudi adults with T1DM.Study design and methodsA cross-sectional study was conducted between December 2021 and February 2022, including 224 patients with T1DM from the University Diabetes Center, Riyadh. Adults aged ≥18 years, diagnosed with T1DM for >1 year, and residing in Saudi Arabia were included. CC knowledge was assessed using a previously well-studied tool (AdultCarbQuiz), which was translated into Arabic and tested for validity by a group of dieticians. Descriptive statistics were used for data analysis, and bivariate and regression analyses were conducted.ResultsThe AdultCarbQuiz questionnaire-Arabic version had good validity and reliability (Cronbach’s α: 0.87). The CC method was used by 54% of the participants. The mean CC knowledge score was 23.01±7.31. A significant negative linear relationship between the participants’ CC knowledge scores, and age and glycated haemoglobin (HbA1c) levels, was revealed by simple regression analysis. Furthermore, significant independent variables related to CC knowledge scores were CC use, HbA1c levels, being taught about CC (>5 times), insulin pump usage and DM duration (≤15 years).ConclusionsApproximately half of the patients used the CC method. The mean CC knowledge scores were better in patients who used the CC method, were more frequently taught about CC, were treated using an insulin pump, and had a shorter DM duration than their counterparts. Therefore, designing and implementing a well-structured nutrition education programme tailored to individuals with diabetes is crucial to provide them with up-to-date dietary information, as well as the necessary knowledge and skills, to improve their outcomes and manage their condition.
Ensuring equity in the era of HLA-restricted cancer therapeutics
Authors: Smithy James W , Blouin Amanda , Diamond Lisa C , Postow Michael 
Published: November 2022

In January 2022, the US Food and Drug Administration granted regulatory approval to tebentafusp, a bispecific T cell receptor protein that targets melanoma antigen gp100 in the context of the human leucocyte antigen (HLA) A*0201 allele. This approval generated significant excitement, given the relative paucity of effective systemic therapies for advanced uveal melanoma. More broadly, tebentafusp represents the first T cell receptor agent to improve overall survival in any solid tumor.Although HLA-A*02:01 is the most common allele at this locus overall, its expression varies considerably among ethnic groups. It is most frequently expressed in Europeans, and less commonly in African Americans and people of Asian or Pacific Island ancestry. While uveal melanoma is most common in Caucasian populations, other HLA-restricted cancer therapeutics are being developed for indications with more diverse patient populations, such as cervical cancer.We advocate for proactive consideration of the populations eligible for each HLA-restricted therapeutic in development to ensure this emerging therapeutic class does not compound long-standing health disparities. As trials may focus on the most prevalent HLA subtypes, it will take the engagement of multiple stakeholders to ensure equitable access to patients of all ethnic backgrounds.