bluuebunny/crossref_metadata_2025_split huggingface dataset:
SISTEM PENDUKUNG KEPUTUSAN PENERIMAAN BLT MENGGUNAKAN METODE WEIGHTED AGGREGATED SUM PRODUCT ASSESMENT (WASPAS)
Authors: Priatama Candra , Pratama Irfan 
Published: November 2022

Bantuan Langsung Tunai (BLT) merupakan salah satu bentuk pemulihan ekonomi berupa jaring pengaman sosial. Pemberian keputusan kepada penerima BLT harus dilakukan dengan baik dan tepat sasaran. Selama ini pemberian dana bantuan sosial di Desa Cintajaya masih menggunakan masih menggunakan aplikasi pendukung seperti Microsoft Excel dan belum adanya database yang mendukung sehingga keakuratan data kurang terjamin. Dari akar permasalahan tersebut akan dibangun sebuah Sistem Pendukung Keputusan untuk menentukan penerima BLT di Desa Cintajaya dengan menggunakan metode Weighted Aggregated Sum Product Assesment (WASPAS). Dalam penelitian ini diperlukan kriteria dan alternatif untuk mendapatkan solusi pengambilan keputusan penerimaan BLT. Sistem pendukung keputusan ini menggunakan sistem berbasis web agar penggunaanya efektif dan efisien. Berdasarkan hasil pengujian dapat disimpulkan bahwa sistem dapat berjalan sesuai dengan metode. Dari 83 alternatif di peroleh bahwa kandidat (ranking teratas) yang layak menerima Bantuan Langsung Tunai adalah 35 alternatif, dengan batasan nilai preferensi (Qi) yang berhak menerima bantuan minimal 0.46074091161547.
TECNOLOGIA DE COMUNICAÇÃO: RELEVÂNCIA NO PROCESSO DE INTERAÇÃO NO ÂMBITO DA COMUNIDADE SURDA
Authors: Missias-Moreira Ramon , Ujiie Nájela Tavares Ujiie 
Published: November 2022

Nas últimas décadas, a tecnologia tem influenciado significativamente no estilo de vida dos indivíduos. Em especial, o sujeito surdo recebeu reflexos dessas mudanças tecnológicas, no âmbito da interação e comunicação. Este artigo contempla objetivos de descrever os aspectos históricos e socioculturais da Tecnologia da Comunicação, compreender a inserção da pessoa com surdez no contexto da contemporaneidade e analisar o uso das tecnologias digitais pelas pessoas com surdez através de uma pesquisa realizada em artigos científicos e literaturas. O presente estudo viabiliza reflexões para que a sociedade venha tomar conhecimento a respeito da relevância dos recursos e serviços virtuais que permitem que os surdos estejam inclusos na era digital.
Palavras-Chave: Tecnologia digital. Interação. Surdos.

ABSTRACT
In the last decades, technology has significantly influenced the lifestyle of individuals. In particular, the deaf subject received reflexes of these technological changes, in the scope of interaction and communication. This article aims to describe the historical and sociocultural aspects of Communication Technology, to understand the insertion of deaf people in this contemporary context, and to analyze the use of digital technologies by them through a survey of scientific articles and literature on this issue. This study makes possible reflections so that society becomes aware of the relevance of the virtual resources and services that allow the deaf person to be included in the digital age.
Keywords: Digital technology. Interaction. Deaf people.
UM ESTADO DO CONHECIMENTO ACERCA DO PROFESSOR HOMEM NA EDUCAÇÃO INFANTIL (2011-2020)
Authors: Souza Araujo Lucas , Tavares Ujiie Nájela 
Published: November 2022

O estudo apresenta um estado do conhecimento acerca da figura do professor homem na Educação Infantil (EI) mediatizado por uma busca no banco de dados da Biblioteca Digital Brasileira de Teses e Dissertações (BDBTD), no que tange as pesquisas realizadas no Brasil, dentro do campo da Educação, no período de 2011 a 2020, com intuito de realizar leitura e análise reflexiva. A partir dos descritores “professor homem na educação infantil” emergiu 146 (cento e quarenta e seis) pesquisas científicas, sendo 116 (cento e dezesseis) dissertações e 30 (trinta) teses, após análise restringiu-se o universo para 16 (dezesseis) dissertações. A partir dos resultados evidencia-se que o campo está em expansão, mas ainda é restrito e que a presença do professor homem na Educação Infantil é permeada de conflitos, tensões, olhares de desconfianças e desafios.
Palavras-chave: Estado do Conhecimento. Professor Homem. Educação Infantil.

ABSTRACT
The study presents a state of knowledge about the figure of the male teacher in Early Childhood Education (EI) mediated by a search in the Brazilian Digital Library of Theses and Dissertations (BDBTD) database, regarding research carried out in Brazil, within the field of Education, from 2011 to 2020, in order to carry out reflective reading and analysis. From the descriptors "male teacher in early childhood education" emerged 146 (one hundred and forty-six) scientific researches, being 116 (one hundred and sixteen) dissertations and 30 (thirty) theses, after analysis, the universe was restricted to 16 (sixteen) dissertations. From the results, it is evident that the field is expanding, but it is still restricted and that the presence of the male teacher in Early Childhood Education is permeated by conflicts, tensions, looks of distrust and challenges.
Keywords: State of Knowledge. Male Teacher. Child education.
ESTIMASI SUMBERDAYA BAUKSIT MENGGUNAKAN METODE GEOSTATISTIK DI PT. XYZ KABUPATEN MEMPAWAH PROVINSI KALIMANTAN BARAT
Authors: Nugraha Faza , Ashari Yunus , Khorniawan Wahyu Budhi 
Published: November 2022

PT. XYZ adalah perusahaan yang bergerak di bidang pertambangan yang sedang melakukan kegiatan eksplorasi bijih bauksit di Kabupaten Mempawah. Maka dari itu perlu dilakukan estimasi sumberdaya untuk melanjutkan ke tahapan produksi. Tujuan penelitian untuk mengetahui penyebaran kadar, estimasi sumberdaya berdasarkan klasifikasi kadar Al2O3, estimasi sumberdaya bauksit tercuci serta tidak tercuci dan mengklasifikasikan sumberdaya bauksit berdasarkan Kriging Efisiensi. Penelitian ini menggunakan perangkat lunak Surpac 6.6.2 dengan metodologi penelitian berupa studi literatur, pengumpulan data, basis data, validasi data, analisis statistik, konstruksi model, penaksiran sumberdaya menggunakan Ordinary Kriging. Pada lokasi penelitian ini, terdapat 114 titik test pit dengan luasan 15,4 Ha dengan jarak antara titik test pit 50m dan pengambilan contoh bauksit dilakukan dengan interval 2m. Berdasarkan data eksplorasi langsung test pit yang kemudian dilakukan perhitungan sumberdaya dengan batasan kadar 35% Al2O3 dan densitas 1,8 ton/m3. Dari hasil pengolahan variogram, sebaran homogenitas kadar Al2O3 cenderung ke arah tenggara atau ke arah kuadran IV 327,58o. Total tonase unwashed bauxite (UBX) sebesar 487.388 ton dan total tonase washed bauxite (WBX) sebesar 239.893 ton. Sumberdaya pada lokasi penelitian diklasifikasikan berdasarkan Kriging Efisiensi. Klasifikasi teraka sebesar 422.438 ton, tertunjuk 160.875 ton, dan terukur 748.688 ton.
KAJIAN TEKNIS LOSSES MATERIAL ORE NIKEL UNTUK MENGHITUNG OPTIMALISASI SHIPMENT RATIO PADA PENAMBANGAN PT. BUKIT MAKMUR ISTINDO NIKELTAMA
Authors: Ramadhan Rezki , Nursanto Edy , Amri Nur Ali 
Published: November 2022

Kegiatan produksi penambangan blok keuno difokuskan pada penambangan material Low Grade Saprolith Ore, Material Low Grade Saprolith Ore adalah kelompok bijih nikel kadar rendah yang diperuntukkan untuk ekspor dengan batas kadar tertentu. Adanya tahapan pemindahan material LSGO dari front penambangan menuju stockyard transito dan stockyard final ore dimaksudkan untuk mengetahui berapa besar persentase losses material LSGO tersebut dan mengetahui faktor apa saja yang menjadi penyebab terjadinya losses material dengan melakukan perhitungan losses menggunakan metode survey dan truck count hauling serta pengamatan kegiatan pemindahan material secara langsung. Didapatkan losses material yang dihasilkan sebesar 2,16% untuk kegitan hauling, penyebab terjadinya losses antara lain adanya material yang melekat pada alat berat dan faktor dumpingan yang membuat sebagian material menjadi landasan bedding basement stockyard transito dan basement lantai stockyard final ore.
A RING-FAULT DELINEATION OF AN ANCIENT VOLCANIC CALDERA BASED ON 3-D GRAVITY INVERSE MODELING IN MAJENANG REGION, INDONESIA
Authors: Handyarso Accep 
Published: November 2022

Calderas are important geological features in all volcanic environments due to give directives clues of geological resources such as geothermal system, mineralization, or even in oil and gas potential reserved. The ability of recognizing these specific features play an important role in the exploration activities. A good understanding of the geological settings will bring to the right direction and make the exploration activities becomes optimized and cost effective. Gravity method is commonly used for preliminary study almost of any cases due to lightweight, low-cost, and the ability to figure out a wide region quickly. Gravity method has an excellent lateral resolution but it has limitation with the vertical resolution. Applying depth-weighting mechanism makes, the inverse-modeling result becomes interpretable. According to the research, there is a northwest-southeast dextral strike-slip fault in the area, which belongs to the Pamanukan-Cilacap Fault Zone (PCFZ). A Circular anomaly pattern also delineated and interpreted as the ring-fault of an ancient volcanic caldera in the study area. Several high gravity anomaly located within the caldera-rims are interpreted as the lava domes or intrusion rocks. The eruption center point estimated at around the Majenang city. The PCFZ behaves as the weak zones in the area where the magmatism rise through and create the ancient volcano, which now remain as the Majenang Caldera.
Keywords: Gravity, Caldera, Ring-Fault, Geological-Resources, Indonesia.
Recent advances in recombinase polymerase amplification: Principle, advantages, disadvantages and applications
Authors: Tan Meiying , Liao Chuan , Liang Lina , Yi Xueli , Zhou Zihan , Wei Guijiang 
Published: November 2022

After the outbreak of SARS-CoV-2, nucleic acid testing quickly entered people’s lives. In addition to the polymerase chain reaction (PCR) which was commonly used in nucleic acid testing, isothermal amplification methods were also important nucleic acid testing methods. Among several common isothermal amplification methods like displaced amplification, rolling circle amplification, and so on, recombinase polymerase amplification (RPA) was recently paid more attention to. It had the advantages like a simple operation, fast amplification speed, and reaction at 37-42°C, et al. So it was very suitable for field detection. However, there were still some disadvantages to RPA. Herein, our review mainly summarized the principle, advantages, and disadvantages of RPA. The specific applications of RPA in bacterial detection, fungi detection, virus detection, parasite detection, drug resistance gene detection, genetically modified food detection, and SARS-CoV-2 detection were also described. It was hoped that the latest research progress on RPA could be better delivered to the readers who were interested in RPA.
Change in patent foramen ovale height is associated with cryptogenic stroke and the construction of a morphology-based scoring system
Authors: Liu Xiaoqin , Zhang Yu , Xie Hang , Zeng Haowei , Sun Jingyan , Su Linjie , Li Bingyi , Xue Xiaoyi , Zhang Yushun 
Published: November 2022

IntroductionCurrent guidelines recommended patent foramen ovale (PFO) occlusion as the preferred treatment for PFO-related cryptogenic stroke (CS); however, finding the causative foramen ovale remains challenging. This study aimed to identify predictors and establish a scoring system by assessing PFO morphology and stroke-related factors.MethodsBased on a prospective multicenter registered clinical trial, we compared data mainly derived from transesophageal echocardiography (TEE) and clinical history in patients with PFO-related CS and those without CS (non-CS) with incidental PFO. Subsequently, we explored independent predictors using logistic analysis, established a scoring system based on the results, and finally evaluated the scoring system using receiver operating characteristic (ROC) analysis and internal validation.Results75 patients with PFO-related CS and 147 non-CS patients were enrolled. Multivariate logistic analysis showed that the change in PFO height, large PFO, atrial septal aneurysm (ASA), and sustained right-to-left shunt (RLS) had independent relationships with CS. Based on the odds ratio value of each independent factor, a scoring system was built: change in PFO height ≥ 1.85 mm (3 points), large PFO (2 points), ASA (5 points), sustained RLS (2 points). 0–2 points correspond to low-risk PFO, 3–5 points medium-risk PFO, and 7–12 points high-risk PFO. ROC analysis showed an area under the curve of 0.80 to predict CS. The proportion of patients with CS is increasing based on these points.ConclusionsOur study screened out the change in PFO height as an independent predictor of CS. A simple and convenient scoring system can provide constructive guidance for identifying whether the PFO is causal and consequently selecting patients more likely to benefit from closure.
Spectrum of underlying diseases in syncope and treatment of neurally-mediated syncope in children and adolescents over the past 30 years: A single center study
Authors: Cui Yaxi , Liao Ying , Zhang Qingyou , Yan Hui , Liu Ping , Wang Yuli , Sun Yan , Xu Wenrui , Liu Xueqin , Du Junbao , Jin Hongfang 
Published: November 2022

BackgroundSyncope is the primary cause of transient loss of consciousness, which causes severe physical and mental burdens to children and adolescents.ObjectiveThe study was designed to analyze the spectrum of underlying diseases of syncope and treatment options for neurally-mediated syncope (NMS) in Chinese children and adolescents.MethodsMedical records including history, physical examination, blood biochemistry, standing test, head-up tilt (HUTT), sitting-up test, electroencephalogram (EEG), electrocardiogram (ECG), and echocardiography were retrospectively studied in children and adolescents admitted to the National Pediatric Syncope Center, Department of Pediatrics, Peking University First Hospital between 1992 and 2021. All the data were collected from the Beijing Kaihua Medical Management System (Kaihua, Beijing, China). Children who met the syncope diagnostic criteria were enrolled in the study. The spectrum of the underlying diseases of syncope in children and adolescents and the treatment options of NMS were analyzed.ResultsA total of 1,947 children and adolescents with syncope were admitted, including 869 males (44.63%) and 1,078 females (55.37%) aged 1–18 years, with an average age of 11.1 ± 3.1 years. The number of children and adolescents with syncope displayed a gradually increasing trend between 1992 and 2021 except after 2020. NMS proportion increased, and the proportion of unexplained syncope decreased (χ2 = 128.839, P &lt; 0.01). The treatment options of NMS mainly included autonomic nervous function exercise (549, 34.46%), oral rehydration salt (ORS; 445, 27.94%), metoprolol (219, 13.75%), midodrine (120, 7.53%), ORS plus metoprolol (139, 8.73%), ORS plus midodrine (120, 7.53%), and pacemakers (1, 0.06%). Patients with vasovagal syncope (VVS) coexisting with postural orthostatic tachycardia syndrome (POTS) were more likely to take pharmacological treatments than those with VVS or POTS only (χ2 = 41.696, P &lt; 0.01).ConclusionThe number of children with syncope displayed an increasing trend before 2020, and the proportion of unexplained syncope decreased. Autonomic nervous function exercise was the most common treatment for children and adolescents with NMS. Children with VVS coexisting with POTS were more likely to receive pharmacological treatments than those with either.
Extracellular matrix and cyclic stretch alter fetal cardiomyocyte proliferation and maturation in a rodent model of heart hypoplasia
Authors: Watson Matthew C. , Williams Corin , Wang Raymond M. , Perreault Luke R. , Sullivan Kelly E. , Stoppel Whitney L. , Black Lauren D. 
Published: November 2022

IntroductionBirth defects, particularly those that affect development of the heart, are a leading cause of morbidity and mortality in infants and young children. Babies born with heart hypoplasia (heart hypoplasia) disorders often have a poor prognosis. It remains unclear whether cardiomyocytes from hypoplastic hearts retain the potential to recover growth, although this knowledge would be beneficial for developing therapies for heart hypoplasia disorders. The objective of this study was to determine the proliferation and maturation potential of cardiomyocytes from hypoplastic hearts and whether these behaviors are influenced by biochemical signaling from the extracellular matrix (ECM) and cyclic mechanical stretch.MethodCongenital diaphragmatic hernia (CDH)-associated heart hypoplasia was induced in rat fetuses by maternal exposure to nitrofen. Hearts were isolated from embryonic day 21 nitrofen-treated fetuses positive for CDH (CDH+) and from fetuses without nitrofen administration during gestation.Results and discussionCDH+ hearts were smaller and had decreased myocardial proliferation, along with evidence of decreased maturity compared to healthy hearts. In culture, CDH+ cardiomyocytes remained immature and demonstrated increased proliferative capacity compared to their healthy counterparts. Culture on ECM derived from CDH+ hearts led to a significant reduction in proliferation for both CDH+ and healthy cardiomyocytes. Healthy cardiomyocytes were dosed with exogenous nitrofen to examine whether nitrofen may have an aberrant effect on the proliferative ability of cardiomyocyte, yet no significant change in proliferation was observed. When subjected to stretch, CDH+ cardiomyocytes underwent lengthening of sarcomeres while healthy cardiomyocyte sarcomeres were unaffected. Taken together, our results suggest that alterations to environmental cues such as ECM and stretch may be important factors in the pathological progression of heart hypoplasia.
Assessment of QRISK3 as a predictor of cardiovascular disease events in type 2 diabetes mellitus
Authors: Mu Xiaodie , Wu Aihua , Hu Huiyue , Zhou Hua , Yang Min 
Published: November 2022

BackgroundThe risk of cardiovascular disease (CVD) in diabetes mellitus (DM) patients is two- to three-fold higher than in the general population. We designed a 10-year cohort trial in T2DM patients to explore the performance of QRESEARCH risk estimator version 3 (QRISK3) as a CVD risk assessment tool and compared to Framingham Risk Score (FRS).MethodThis is a single-center analysis of prospective data collected from 566 newly-diagnosed patients with type 2 DM (T2DM). The risk scores were compared to CVD development in patients with and without CVD. The risk variables of CVD were identified using univariate analysis and multivariate cox regression analysis. The number of patients classified as low risk (&lt;10%), intermediate risk (10%-20%), and high risk (&gt;20%) for two tools were identified and compared, as well as their sensitivity, specificity, positive and negative predictive values, and consistency (C) statistics analysis.ResultsAmong the 566 individuals identified in our cohort, there were 138 (24.4%) CVD episodes. QRISK3 classified most CVD patients as high risk, with 91 (65.9%) patients. QRISK3 had a high sensitivity of 91.3% on a 10% cut-off dichotomy, but a higher specificity of 90.7% on a 20% cut-off dichotomy. With a 10% cut-off dichotomy, FRS had a higher specificity of 89.1%, but a higher sensitivity of 80.1% on a 20% cut-off dichotomy. Regardless of the cut-off dichotomy approach, the C-statistics of QRISK3 were higher than those of FRS.ConclusionQRISK3 comprehensively and accurately predicted the risk of CVD events in T2DM patients, superior to FRS. In the future, we need to conduct a large-scale T2DM cohort study to verify further the ability of QRISK3 to predict CVD events.
Association of COVID-19 mortality with serum selenium, zinc and copper: Six observational studies across Europe
Authors: Demircan Kamil , Chillon Thilo Samson , Bracken Tommy , Bulgarelli Ilaria , Campi Irene , Du Laing Gijs , Fafi-Kremer Samira , Fugazzola Laura , Garcia Alejandro Abner , Heller Raban , Hughes David J. , Ide Louis , Klingenberg Georg Jochen , Komarnicki Pawel , Krasinski Zbigniew , Lescure Alain , Mallon Patrick , Moghaddam Arash , Persani Luca , Petrovic Mirko , Ruchala Marek , Solis Morgane , Vandekerckhove Linos , Schomburg Lutz 
Published: November 2022

IntroductionCertain trace elements are essential for life and affect immune system function, and their intake varies by region and population. Alterations in serum Se, Zn and Cu have been associated with COVID-19 mortality risk. We tested the hypothesis that a disease-specific decline occurs and correlates with mortality risk in different countries in Europe.MethodsSerum samples from 551 COVID-19 patients (including 87 non-survivors) who had participated in observational studies in Europe (Belgium, France, Germany, Ireland, Italy, and Poland) were analyzed for trace elements by total reflection X-ray fluorescence. A subset (n=2069) of the European EPIC study served as reference. Analyses were performed blinded to clinical data in one analytical laboratory.ResultsMedian levels of Se and Zn were lower than in EPIC, except for Zn in Italy. Non-survivors consistently had lower Se and Zn concentrations than survivors and displayed an elevated Cu/Zn ratio. Restricted cubic spline regression models revealed an inverse nonlinear association between Se or Zn and death, and a positive association between Cu/Zn ratio and death. With respect to patient age and sex, Se showed the highest predictive value for death (AUC=0.816), compared with Zn (0.782) or Cu (0.769).DiscussionThe data support the potential relevance of a decrease in serum Se and Zn for survival in COVID-19 across Europe. The observational study design cannot account for residual confounding and reverse causation, but supports the need for intervention trials in COVID-19 patients with severe Se and Zn deficiency to test the potential benefit of correcting their deficits for survival and convalescence.
Human amniotic fluid derived extracellular vesicles attenuate T cell immune response
Authors: del Rivero Tania , Milberg Julian , Bennett Cassie , Mitrani Maria Ines , Bellio Michael A. 
Published: November 2022

IntroductionExtracellular vesicles isolated from human amniotic fluid (AF-EVs) have previously been found to modulate inflammation and macrophage infiltration in a mouse model. However, the effects of acellular amniotic fluid (acAF) or AF-EVs on the T-Cell immune response have not been explored.MethodsIn this study, we investigated the effects of acAF and AF-EVs on the T cell immune response in an in vitro cell culture model. Peripheral Blood Mononuclear Cells (PBMCs) were stimulated with Phytohemagglutinin (PHA) to induce the immune response and were subsequently treated with either serum-free media (vehicle), acAF, or concentrated AF-EVs. ResultsBoth acAF and AF-EV treatment suppressed PHA-induced T cell proliferation and PHA-induced T cell activation; however, treatment with concentrated AF-EVs had a greater effect. Additionally, both acAF and AF-EVs reduced PBMC pro-inflammatory cytokine release. AF-EVs were found to be taken up by both CD4+ and CD8+ effector T cell subsets.ConclusionOverall, this data demonstrates that AF-EVs have a robust immunomodulatory effect on T cells and suggests AF-EVs could be used as an immunotherapeutic tool.