bluuebunny/crossref_metadata_2025_split huggingface dataset:
Misclassification of nodal stage in gastric cancer: 16 lymph nodes is not enough
Authors: Miftode Sorin , Bruns Helge 
Published: April 2022

Abstract
Background
In gastric cancer, nodal stage plays an important role. Insufficient lymph node harvesting or incomplete examination may lead to misclassification and affect postoperative strategy and group survival. This study’s objective was to determine the minimum number of examined lymph nodes needed in gastric cancer and compare this to the minimum lymph node count according to the current Union for International Cancer Control (UICC) classification using real world data.

Methods
Based on anatomical data, expected mean lymph node counts and their 95% confidence intervals for complete D2 lymphadenectomy were calculated. Using stochastic analysis, a threshold for correct classification in 95% of cases was determined. Survival data of nodal negative gastric cancer patients was extracted from the Surveillance, Epidemiology, and End Results (SEER)-Database for 2010–2017. Patients reaching at least the calculated theoretical threshold were compared to the minimum threshold according to the current UICC classification.

Results
The expected lymph node count was 30 (95% CI: 28–32; range 17–52), corresponding to a 27 lymph nodes. In nodal negative patients with exactly 16 and at least 27 examined lymph nodes, relative 5 year survival was 79 and 89% in T1/T2 and 39 and 64% T3/T4 gastric cancer, respectively. Theoretically, when only 16 lymph nodes are analyzed, nodal negative staging may be incorrect in up to 47% of cases.

Conclusions
A minimum threshold of 16 examined lymph nodes cannot be justified. Retrospective analysis confirmed systematic misclassification of patients with insufficient lymphadenectomy in nodal negative gastric cancer patients. Correct lymphadenectomy and thorough examination of the surgical specimen is mandatory.
Defining Reference Ranges for Serum Anti-Müllerian Hormone on a Large Cohort of Normozoospermic Adult Men Highlights New Potential Physiological Functions of AMH on FSH Secretion and Sperm Motility
Authors: Benderradji Hamza , Barbotin Anne-Laure , Leroy-Billiard Maryse , Prasivoravong Julie , Marcelli François , Decanter Christine , Robin Geoffroy , Mitchell Valérie , Rigot Jean-Marc , Bongiovanni Antonino , Sauve Florent , Buée Luc , Maurage Claude-Alain , Cartigny Maryse , Villers Arnauld , Prevot Vincent , Catteau-Jonard Sophie , Sergeant Nicolas , Giacobini Paolo , Pigny Pascal , Leroy Clara 
Published: April 2022

AbstractBackgroundFew studies to date have attempted to measure serum anti-Müllerian hormone (AMH) levels in adult men, and solid references ranges have not yet been defined in a large cohort.ObjectiveIn this study, we aimed, first, to establish the reference ranges for serum AMH and AMH-to-total testosterone ratio (AMH/tT) in adult males. Second, we investigated the relationship between serum AMH and both reproductive hormones and semen parameters.MethodsThis single-center retrospective study included 578 normozoospermic adult men. Serum AMH concentrations were determined with an automated sandwich chemiluminescent immunoassay.ResultsThe median serum AMH was 43.5 pmol/L. The 2.5th and 97.5th percentile values for serum AMH and AMH/tT were 16.4 and 90.3 pmol/L and 0.45 and 3.43, respectively. AMH was positively correlated with inhibin B and sperm concentration and negatively correlated with age, follicle-stimulating hormone (FSH), and progressive sperm motility. Interestingly, using immunofluorescence, we documented for the first time that AMH type II receptor (AMH-R2) is expressed in ejaculated human spermatozoa and gonadotrophic cells in the postmortem pituitary gland.ConclusionsWe establish a new age-specific reference range for serum AMH and AMH/tT. Moreover, AMH-R2 expression in human spermatozoa and gonadotrophic cells, together with the relationship between serum AMH levels and sperm motility or mean FSH levels, highlight new potential functions of AMH in regulating sperm motility or FSH secretion in adult men.
Jumonji Domain–containing Protein-3 (JMJD3/Kdm6b) Is Critical for Normal Ovarian Function and Female Fertility
Authors: Roy Sambit , Sinha Niharika , Huang Binbin , Cline-Fedewa Holly , Gleicher Norbert , Wang Jianrong , Sen Aritro 
Published: April 2022

AbstractIn females, reproductive success is dependent on the expression of a number of genes regulated at different levels, one of which is through epigenetic modulation. How a specific epigenetic modification regulates gene expression and their downstream effect on ovarian function are important for understanding the female reproductive process. The trimethylation of histone3 at lysine27 (H3K27me3) is associated with gene repression. JMJD3 (or KDM6b), a jumonji domain–containing histone demethylase specifically catalyzes the demethylation of H3K27me3, that positively influences gene expression. This study reports that the expression of JMJD3 specifically in the ovarian granulosa cells (GCs) is critical for maintaining normal female fertility. Conditional deletion of Jmjd3 in the GCs results in a decreased number of total healthy follicles, disrupted estrous cycle, and increased follicular atresia culminating in subfertility and premature ovarian failure. At the molecular level, the depletion of Jmjd3 and RNA-seq analysis reveal that JMJD3 is essential for mitochondrial function. JMJD3-mediated reduction of H3K27me3 induces the expression of Lif (Leukemia inhibitory factor) and Ctnnb1 (β-catenin), that in turn regulate the expression of key mitochondrial genes critical for the electron transport chain. Moreover, mitochondrial DNA content is also significantly decreased in Jmjd3 null GCs. Additionally, we have uncovered that the expression of Jmjd3 in GCs decreases with age, both in mice and in humans. Thus, in summary, our studies highlight the critical role of JMJD3 in nuclear–mitochondrial genome coordination that is essential for maintaining normal ovarian function and female fertility and underscore a potential role of JMJD3 in female reproductive aging.
The Impact of Neoadjuvant Chemotherapy on the Surgical Management of Colorectal Peritoneal Metastases: A Systematic Review and Meta-Analysis
Authors: Flood Michael P. , Kong Joseph C. H. , Wilson Kasmira , Mohan Helen , Waters Peadar S. , McCormick Jacob J. , Warrier Satish K. , Tie Jeanne , Ramsay Robert , Michael Michael , Heriot Alexander G. 
Published: April 2022

Abstract
Background
Cytoreductive surgery (CRS) with or without hyperthermic intraperitoneal chemotherapy (HIPEC) is a well-recognised treatment option for the management of colorectal peritoneal metastases (CRPM). However, incorporating the routine use of neoadjuvant chemotherapy (NAC) into this management plan is controversial.

Methods
A systematic review and meta-analysis were conducted to evaluate the impact of neoadjuvant chemotherapy on perioperative morbidity and mortality, and long-term survival of patients with CRPM undergoing CRS and HIPEC.

Results
Twelve studies met the inclusion criteria (n = 2,463 patients). Ten were retrospective cohort, one was prospective cohort, and one was a prospective randomised by design. Patients who received NAC followed by CRS and HIPEC experienced no difference in major perioperative morbidity and mortality compared with patients who underwent surgery first (SF). There was no difference in overall survival at 3 years, but at 5 years NAC patients had superior survival (relative risk [RR] 1.31; 95% confidence interval [CI] 1.11–1.54, P < 0.001). There were no differences in 1- and 3-year, disease-free survival (DFS) between groups. Study heterogeneity was generally high across all outcome measures.

Conclusions
Patients who received neoadjuvant chemotherapy did not experience any increase in perioperative morbidity or mortality. The potential improvement in 5-year overall survival in patients receiving NAC is based on limited confidence due to several limitations in the data, but not sufficiently enough to curtail its use. The practice of NAC in this setting will remain heterogeneous and guided by retrospective evidence until prospective, randomised data are reported.
On α-nuclearity and total accessibility for some tensor norms α
Authors: Kaijser Sten , Reinov Oleg 
Published: April 2022

For a tensor norm α on the class of all Banach spaces there is a natural way to define the Banach operator ideal Nα associated with the tensor norm. We give sufficient conditions for an operatorto be in Nα if its second adjoint posesses this property. We show one way to get from this the negative answers to some questions of A. Defant and K. Floret: their tensor norms g∞, w1 and w∞ are not totally accessible.
On transitivity of M(r,s)-inequalities and geometry of higher duals of Banach spaces
Authors: Haller Rainis 
Published: April 2022

In this note we study the transitivity of M(r,s)-inequalities and geometry of higher duals of Banach spaces. Our main theorem shows that if X and Y are closed subspaces of a Banach space Z such that X is an ideal satisfying the M(r,s)-inequality in Y and Y is an ideal satisfying the M(r,s)-inequality in Z, then X is an ideal satisfying the M(r/(2−r),s/(2−r))-inequality in Z. This extends the corresponding result for M-ideals. As an application we show that if a Banach space X is an ideal satisfying the M(r,s)-inequality in its bidual, then X is an ideal satisfying the M(r/(r+n(1−r)),c/(r+n(1−r)))-inequality in its dual space of order 2n for every n∈N. It follows that if X is an ideal satisfying the M(1,s)-inequality in its bidual, then X has the strong uniqueness property SU in all its duals of even order. These results generalize the corresponding results for M-ideals established by Rao [R].
Audit and re-audit of medication use in patients with impaired kidney function
Authors: Allison Katie 
Published: April 2022

Background: Medications prescribed for patients with chronic kidney disease (CKD) often require dose adjustments to ensure safety and efficacy. An audit was undertaken in primary care to assess how appropriate current medication use is in this patient cohort. Aim: To identify medications most likely to be prescribed at inappropriate doses in patients with CKD 3-5. Methods: Level 2 medication reviews were carried out by a clinical pharmacist for patients with a diagnosis of CKD level 3-5. The reviews focused on how appropriate medication use/dosages were where dose reduction or discontinuation would be recommended for patients with poor renal function. The audit was repeated a year later. Findings: Drugs that required creatinine clearance (CrCl) to be calculated had the most interventions: eight patients had dose changes implemented for rivaroxaban. Conclusion: The use of the correct calculation and regular review to assess the use and dose of medications in patients with poor renal function is vital in improving health outcomes.
Predicting Surface Resistivity on Concretes Containing Potential Supplementary Cementitious Materials Cured at Nonelevated and Elevated Temperatures
Authors: Rios Renee T. , Israel Alexandra A. , Kurtis Kimberly E. 
Published: April 2022

Abstract
Time-series surface resistivity (SR) measurements with up to 56 days of hydration on concretes containing potential supplementary cementitious materials (SCMs) cured at an ambient temperature of 23°C and an elevated temperature of 38°C have the potential to indirectly determine the reactivity of many of these SCMs more accurately than conventional indirect testing metrics, such as the strength activity index in ASTM C618, Standard Specification for Coal Fly Ash and Raw or Calcined Natural Pozzolan for Use in Concrete. SR time-series measurements can distinguish between microstructural densification caused by inert materials and densification caused by pozzolanic materials. However, it may be possible to assess pozzolanicity earlier in the test series, particularly when additional physical and chemical data regarding the material are known. The aim of this paper is to develop predictive models using machine learning on a broad range of both ASTM C618 conforming and nonconforming materials’ time-series SR curves based on the materials’ physical and chemical characteristics and early SR measurement data. Gaussian process regression models were used to predict the SR values of concretes cured at two different temperatures. These models can rapidly screen materials based solely on their chemical and physical characteristics to predict SR curves, which can then be used to determine a material’s suitability for beneficial use in concrete. Models using early age SR measurements were produced to predict the 56-day SR value for concretes cured at both elevated and nonelevated temperatures. This data-driven approach allows for the design of novel reactive materials, the inclusion of existing reactive materials in construction, and a reduction in testing durations.
Mechanical Properties and Microstructural Characteristics of AA5356 Aluminum Alloy Cylindrical Components Made by Wire Arc Additive Manufacturing Process
Authors: Prasanna Nagasai Bellamkonda , Malarvizhi S. , Balasubramanian V. 
Published: April 2022

Abstract
Wire arc additive manufacturing (WAAM) is a high-quality technology for producing large and complicated geometries in close proximity to net shape with low-cost production resources, including welding machines and filler wires. It offers the cost-effective fabrication of large-scale metal parts with high deposition. AA5356 aluminum–magnesium (Al-Mg) alloys can reach medium strength without a solid solution and quenching treatment, thereby avoiding product distortion caused by quenching, which has attracted the attention of WAAM researchers. However, challenges during the additive manufacturing of aluminum alloys, such as porosity or poor mechanical properties, can be overcome by using arc technologies with low heat input. This paper presents metallurgical characteristics and mechanical properties of WAAM AA5356 alloy cylindrical components fabricated by gas metal arc welding (GMAW) and cold metal transferred (CMT) arc welding processes. Herein, a comparison between the welding processes and the resulting heat input shows the effect on the resulting microstructure and the mechanical properties of additively manufactured AA5356 parts. Firstly, the influence of heat input on the porosity and microstructural characteristics were analyzed. Subsequently, the effect of heat input on the mechanical properties of the cylindrical components was studied. The cylindrical component produced by CMT process exhibits fewer and smaller pores with finer grains and reduced segregation of β-(Al3Mg2) phases than the GMAW process. The component fabricated by CMT process showed isotropic superior mechanical properties (tensile properties, hardness, and impact toughness) than the component made by GMAW process.
Caracterização de poluição sonora e perturbação do sossego em uma fonte tonal: o caso da sirene da lanchonete
Authors: Cotomacio André Carrara 
Published: April 2022

A caracterização da poluição sonora constitui-se um desafio por se tratar de um tipo de evento que deixa vestígios de difícil quantificação e análise, cessando assim que interrompida a atividade da fonte emissora. Apesar de haver normas que tratam da questão no ordenamento jurídico brasileiro, as medidas adotadas pelo poder público no sentido de caracterização desse tipo de poluição podem não ser tomadas de forma eficaz, principalmente devido à especificidade da norma técnica vigente e às dificuldades em sua interpretação por parte do Perito Criminal. Visando colaborar para uma maior facilitação nesse sentido, o presente trabalho consiste em um relato de experiência a respeito da medição dos níveis de pressão sonora de uma fonte poluidora em uma lanchonete, visando fornecer à autoridade requisitante elementos que possibilitassem a tipificação dos delitos cabíveis. Destarte, foi possível estabelecer os níveis de pressão sonora, conforme o exigido pela norma ABNT NBR 10151:2019, a partir dos procedimentos técnicos necessários para a caracterização de uma sirene como uma fonte emissora de ruído do tipo tonal. No presente relato são discutidos os aspectos e as dificuldades na aplicação da referida norma técnica, bem como as possíveis implicações penais.
Étude comparatif sur la compétence des étudiants de deuxième semestre dans le test d’expression orale basé sur la stimulation d’image et sans d’image
Authors: Hidayah Siti Akmalul , Widayanti Diah Vitri 
Published: April 2022

Abstract
Parler est l’une des compétences de la langue qui doit être formée et pratiquée régulièrement. Les dessins pourraient donner une aide à s'exprimer, mais ils pourraient donner un obstacle aux apprenants lorsqu’ils ne connaissent pas le vocabulaire. C’est la raison pour laquelle cette recherche est menée. L’objectif de cette recherche est de décrire s'il y a des différences dans la capacité des étudiants du deuxième semestre du programme enseignement de la langue française à passer le test d'oral basé sur des images et sans images. Cette recherche utilise la validité du contenu et la formule de la corrélation product-moment pour mesurer la fiabilité. Les données obtenues sont ensuite analysées en utilisant la formule du t-test. Selon le calcul, t-calcul > t-tableau, t-calcul = 2,7 et ttableau = 1,94. Donc, l’hypothèse proposée est reçue. Cela veut dire qu’il y a différence significative dans la compétence des étudiants à l'oral entre ceux ayant les stimuli visuels ou dessins et ceux qui ne les ont pas
Abstract
Speaking is one of the language skills that must be trained and practiced regularly. The pictures could help expressing themselves, but they could give a hindrance to learners when they do not know the vocabulary. This is the reason this research is being conducted. The objective of this research is to describe whether there are any differences in the ability of students in the second semester of the French Language Teaching program to pass the oral test based on stimulating pictures and stories. The research approach is descriptive and quantitative. This research uses content validity and the product-moment correlation formula to measure reliability. The data obtained is then analyzed using the t-test formula. According to the calculation, t-calculation> t-table, t-calculation = 2.7 and t-table = 1.94. So the proposed hypothesis is accepted. This means that there is a significant difference in the skills of students speaking between those with visual stimuli or pictures and those who do not
Le Développement de La Fiche Pédagogique Basée Sur Les Chansons D’enfants Indonésiennes Traduites en Français Pour La Classe X Au Lycée
Authors: Nurahman Rian , Handayani Sri 
Published: April 2022

Abstract
L'objectif principal de cette recherche est de produire des fiches pédagogiques de chansons d'enfants indonésiennes traduites en français pour les lycéens de la classe X. Basée sur l'identification des potentialités et des problèmes, l'utilisation des chansons pour l'apprentissage des langues étrangères, notamment le français au lycée, fait généralement utilisent des chansons pop ou des chansons pour enfants, mais les références aux sources de chansons enfants indonésiennes, font encore défaut. Étant donné que les lycéens connaissent mieux les chansons d'enfants indonésiennes, par conséquent, cette étude produit des fiches pédagogiques utilisant des chansons d'enfants indonésiennes. Cette étude utilise la méthode de recherche et développement qui adopte cinq étapes ; formuler des potentialités et des problèmes, collecter des données, concevoir des produits, valider et réviser des conceptions. L'analyse des besoins montre que l'enseignant a besoin de références supplémentaires pour apprendre le français en utilisant des chansons d'enfants indonésiens et le résultat de cette recherche est de produire des fiches pédagogiques utilisant des chansons d'enfants indonésiennes traduites en français pour les lycéens en classe X.
Abstract
The main objective of this research is to produce a collection of lesson plans using Indonesian children's songs translated French for Senior High School students in X class. Based on the identification of potentials and problems, the use of songs for learning foreign languages, especially French in high school, generally uses pop songs or children's songs, but references to sources of children's songs, especially Indonesian children's songs, are still lacking. Given that students are certainly more familiar with Indonesian children's songs, therefore, this study resulted in a collection of lesson plans using Indonesian children's songs. This study uses a research and development method that adopts five steps; formulating potentials and problems, collecting data, making product designs, validating and revising designs. Needs analysis show that the teacher needs additional references for learning French using Indonesian children's songs and the result of this research is produce a collection of lesson plans using Indonesian children's songs translated French for high school students in X class..
Patterns of distribution and peculiarities of formation of gold ore mineralization in metamorphic and black shale strata of Azerbaijan
Authors: Mamedov Musa N. , Mansurov Mamoy I. , Kerimov Vagif M. , Ganbarova Eyzangul F. , Mamedova Aygun G. , Shamiev Ruslan A. 
Published: April 2022

The article discusses the patterns of distribution and the peculiarities of the formation of gold mineralization in the metamorphic and black shale strata of Azerbaijan in order to determine metallogenic specialization. Mineragenic analysis of gold-bearing territories was carried out using numerous data of quantitative studies of the substance of the studied objects: ore-bearing sedimentary and metamorphic strata, ore bodies and processes ore genesis. The spatio-temporal relationships of gold-bearing mineralization of various material-morphological types, conditioned by lithological-geochemical conditions and time of manifestation of lithogenetic processes and metamorphism, have been determined. In the petrographic description of the studied rocks, two groups were distinguished: Early Paleozoic crystalline shales and Upper Paleozoic sedimentary rocks. It has been determined that the shales were initially enriched with gold during sedimentogenesis. In subsequent processes of metamorphism, part of the gold was removed from the shale and redeposited, and thus spread unevenly. Favourable zones of ore deposition could lead to the concentration of gold in shales in industrial conditions. In the studied crystalline shales, attention is drawn to the contents of Pt and Pd, the commonest elements of the platinum group. The Pt content in shales is 0.08 g / T on average, while the clarke for clayey shales is 0.03 g / t, i. e. almost three times higher than the clarke. Even more contrasting is the content of the platinum group element, palladium. In shales, the Pd content is 0.046 g / t. These data, together with the high gold content in the shales, can be considered as a typomorphic geochemical feature of the crystalline shales of the Asrikçay massif of the pre-Jurassic basement of the Lesser Caucasus. The studies have shown that during the formation of gold mineralization in metamorphic and black shale strata, an important role was played by the features of the host carbonaceous sedimentary complexes, which served as additional sources of noble and associated metals. Some of the ore elements in unaltered sediments have their own mineral forms.