bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identification of functional pathways for regenerative bioactivity of selected renal cells
Authors: Sha Wei , Bertram Timothy , Jain Deepak , Brouwer Cory , Basu Joydeep 
Published: February 2022

Abstract
Background
Selected renal cells (SRC) are in Phase II clinical trials as a kidney-sourced, autologous, tubular epithelial cell-enriched cell-based therapy for chronic kidney disease (CKD). In preclinical studies with rodent models of CKD, SRC have been shown to positively modulate key renal biomarkers associated with development of the chronic disease condition.

Methods
A comparative bioinformatic analysis of transcripts specifically enriched or depleted in SRC component sub-populations relative to the initial, biopsy-derived cell source was conducted.

Results
Outcomes associated with therapeutically relevant bioactivity from a systematic, genome-wide transcriptomic profiling of rodent SRC are reported. Key transcriptomic networks and concomitant signaling pathways that may underlie SRC mechanism of action as manifested by reparative, restorative, and regenerative bioactivity in rodent models of chronic kidney disease are identified. These include genes and gene networks associated with cell cycle control, transcriptional control, inflammation, ECM–receptor interaction, immune response, actin polymerization, regeneration, cell adhesion, and morphogenesis.

Conclusions
These data indicate that gene networks associated with development of the kidney are also leveraged for SRC regenerative bioactivity, providing evidence of potential mechanisms of action.
The impact of surge adaptations on hospitalist care teams during the COVID-19 pandemic utilizing a rapid qualitative analysis approach
Authors: Keniston Angela , Patel Vishruti , McBeth Lauren , Bowden Kasey , Gallant Alexandra , Burden Marisha 
Published: February 2022

AbstractBackgroundHospital systems have rapidly adapted to manage the influx of patients with COVID-19 and hospitalists, specialists in inpatient care, have been at the forefront of this response, rapidly adapting to serve the ever-changing needs of the community and hospital system. Institutional leaders, including clinical care team members and administrators, deployed many different strategies (i.e. adaptations) to manage the influx of patients. While many different strategies were utilized in hospitals across the United States, it is unclear how frontline care teams experienced these strategies and multifaceted changes. As these surge adaptations likely directly impact clinical care teams, we aimed to understand the perceptions and impact of these clinical care and staffing adaptations on hospitalists and care team members in order to optimize future surge plans.MethodsQualitative, semi-structured interviews and focus groups with hospitalist physicians, advanced practice providers (APPs), and hospital nursing and care management staff at a quaternary academic medical center. Interviews focused on the impact of COVID-19 surge practices on the following areas: (1) the experience of clinical care teams with the adaptations used to manage the surge (2) the perception and experience with the communication strategies utilized (3) the personal experience with the adaptations (i.e. how they impacted the individual) and (4) if participants had recommendations on strategies for future surges. We utilized rapid qualitative analysis methods to explore themes and subthemes.ResultsWe conducted five focus groups and 21 interviews. Three themes emerged from the work including (1) dynamic clinical experience with a lot of uncertainty, (2) the importance of visible leadership with a focus on sense-making, and (3) the significant emotional toll on care team members. Subthemes included sufficient workforce, role delineation and training, information sharing, the unique dichotomy between the need for flexibility and the need for structure, the importance of communication, and the emotional toll not only on the provider but their families. Several recommendations came from this work.ConclusionsCOVID-19 surge practices have had direct impact on hospitalists and care team members. Several tactics were identified to help mitigate the many negative effects of COVID-19 on frontline hospitalist providers and care teams.
Stem cell therapy for COVID-19 pneumonia
Authors: Kebria Maziar Malekzadeh , Milan Peiman Brouki , Peyravian Noshad , Kiani Jafar , Khatibi Soheil , Mozafari Masoud 
Published: February 2022

AbstractSevere Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) virus is a highly contagious microorganism, and despite substantial investigation, no progress has been achieved in treating post-COVID complications. However, the virus has made various mutations and has spread around the world. Researchers have tried different treatments to reduce the side effects of the COVID-19 symptoms. One of the most common and effective treatments now used is steroid therapy to reduce the complications of this disease. Long-term steroid therapy for chronic inflammation following COVID-19 is harmful and increases the risk of secondary infection, and effective treatment remains challenging owing to fibrosis and severe inflammation and infection. Sometimes our immune system can severely damage ourselves in disease. In the past, many researchers have conducted various studies on the immunomodulatory properties of stem cells. This property of stem cells led them to modulate the immune system of autoimmune diseases like diabetes, multiple sclerosis, and Parkinson's. Because of their immunomodulatory properties, stem cell-based therapy employing mesenchymal or hematopoietic stem cells may be a viable alternative treatment option in some patients. By priming the immune system and providing cytokines, chemokines, and growth factors, stem cells can be employed to build a long-term regenerative and protective response. This review addresses the latest trends and rapid progress in stem cell treatment for Acute Respiratory Distress Syndrome (ARDS) following COVID-19.
Implementation and Evaluation of Educational Videos to Improve Cancer Knowledge and Patient Empowerment
Authors: Tilly Alyssa E. , Ellis Grace K. , Chen Jane S. , Manda Agness , Salima Ande , Mtangwanika Asekanadziwa , Tewete Blessings , Kaimila Bongani , Kasonkanji Edwards , Kayira Ella , Chikasema Maria , Nyirenda Ruth , Bingo Samuel , Chiyoyola Sara , Seguin Ryan , Gopal Satish , Zuze Takondwa , Tomoka Tamiwe , Westmoreland Katherine D. 
Published: February 2022

PURPOSE Low health literacy is a leading cause of treatment abandonment among patients receiving cancer care at Kamuzu Central Hospital (KCH) in Malawi. METHODS We developed cancer educational videos featuring Malawian providers and played them in the KCH oncology clinic. The videos addressed cancer-related topics, including disease biology, common myths, diagnostic procedures, treatment, side effects, and survivorship. After 6 months of implementation, we compared results from 50 pre- and postintervention surveys to assess change in cancer knowledge and care experience. RESULTS Both pre- and postintervention cancer knowledge were good: a median of nine questions were answered correctly of 11 in both assessments. Despite the intervention, most continued to incorrectly identify cancer as an infection (pre: n = 26, 52%; post: n = 25, 50%; P = 1.0), although improvements were observed in patients' knowledge of correct actions for fever at home (pre: n = 38, 76%; post: n = 43, 86%; P = .31). Care experiences were overall good. Postintervention results indicate that more patients felt always listened to by their providers (pre: n = 18, 36%; post: n = 29, 58%; P < .01). However, we also noted a higher rate of patient dissatisfaction of care as more patients felt that they could not understand chemotherapy counseling (pre: n = 11, 22%; post: n = 22, 44%; P < .01). Assessments of video satisfaction indicate that patients found the videos very helpful in terms of understanding their disease (n = 47, 96%) and side effects (n = 48, 98%) and felt empowered to speak up with their providers (n = 46, 96%). CONCLUSION Standardized education materials for patients that can be feasibly implemented throughout sub-Saharan Africa are urgently needed. Cancer educational videos are a low-cost way to educate and empower patients with cancer in resource-constrained settings although in-person discussions remain a crucial part of care.
Spine Pain and Metastatic Prostate Cancer: Defining the Contribution of Nonmalignant Etiologies
Authors: Ruppert Lisa Marie , Cohn Erica Dayan , Keegan Niamh M. , Bacharach Abigail , Woo Sungmin , Gillis Theresa , Scher Howard I. 
Published: February 2022

PURPOSE: In patients with metastatic prostate cancer (MPC), the contribution of nonmalignant etiologies to morbidity is often overlooked. METHODS: We retrospectively reviewed the documented specialist assessments of back pain in men with MPC in a joint medical oncology and physiatry clinic at our tertiary cancer care center. Data on cancer disease extent, hormonal status, sites of spread, pain characteristics, physiatric examination findings, imaging, and recommended management were reviewed, extracted, and codified. For those with back pain at a site of known disease, pain etiology was classified as malignant, nonmalignant, or mixed. RESULTS: Ninety-three men were collaboratively assessed for back pain, 24 (26%) with a biochemical recurrence and 69 (74%) with MPC of whom 53 (77%) reported pain in an area of known spinal metastases including 35 (66%) metastatic castration-resistant disease and 34 (64%) a precancer history of back pain. The presenting pain symptoms of the 53 patients were activity-related in 22 (42%), radicular in eight (15%), transitional movement–related in seven (13%), biologic in five (9%), and multifactorial in 11 (21%). Overall, pain was deemed malignant in 20 (38%; five castration-sensitive, 15 metastatic castration resistant prostate cancer), nonmalignant in 12 (23%; four castration-sensitive, eight CRPC), and of mixed etiology in 21 (40%; nine castration-sensitive, 12 CRPC). CONCLUSION: Nonmalignant etiologies contributed significantly to back pain at sites of metastatic spread for 33/53 (62%) patients with MPC assessed by medical oncology and physiatry. We recommend multidisciplinary care for patients with MPC and back pain to address nonmalignant etiologies that contribute to functional compromise.
Treatment Strategies for Different Types of Intraneural Offending Vessels in Microvascular Decompression Surgery for Trigeminal Neuralgia: An Analytic Report of 58 Cases
Authors: Shen Zhaoli , Yu Feng , Xue Fei , Wang Yuhai , Kwok Sze Chai , Yin Jia 
Published: February 2022

BACKGROUND:
Microvascular decompression (MVD) surgery is the treatment of choice for trigeminal neuralgia (TGN). However, decompression becomes difficult when the offending vessel penetrates the trigeminal nerve root.

OBJECTIVE:
To estimate the rates and patterns of different types of intraneural offending vessels in patients with TGN for MVD and to discuss respective management strategies.

METHODS:
All patients with TGN undergoing MVD in our center from January 1, 2015, to December 31, 2019, were analyzed retrospectively. The intraneural offending vessels included veins and arteries. The postoperative pain relief rate, complications, and recurrences were evaluated.

RESULTS:
Of the 302 TGN cases, the intraneural offending vessels were identified in 58 of the cases (19.2%). The 9 cases (15.5%) of intraneural offending arteries were decompressed using shredded Teflon wrapping interposition. Of the 49 cases (84.5%) of intraneural offending veins (INOVs), 29 were not considered true offending vessels, and the treatment only addressed the offending artery in these patients. Of the remaining 20 INOVs, 15 were electrocoagulated and divided, and 5 were decompressed with shredded Teflon. Complete pain relief was achieved in all 58 patients. However, the pain recurred in 5 patients (8.6%), and transient hemifacial numbness occurred in 4 patients (6.9%).

CONCLUSION:
Intraneural offending vessels requiring treatment are uncommon and are seen in less than 1 in 10 patients undergoing MVD for TGN. For intraneural offending artery, decompression by shredded Teflon wrapping interposition is recommended. Management of the INOV depends on the individual situations, and the management includes sacrifice, wrapping decompression, or leaving them untreated.
Assessment of patient satisfaction toward pharmaceutical benefit package provided by a health insurance corporation of Khartoum State
Authors: Osman Mohamed Ahmed , Shoaib Hussain Ahmed , Omar Alhaj Manasik 
Published: February 2022

Background: Patient satisfaction is an important measure of health service and a key indicator of the quality of health service. Studies focus on how to improve quality rather than patient satisfaction. This study was conducted to identify patients’ satisfaction with the pharmaceutical service package of Health Insurance Corporation of Khartoum State in Jabal-Awliya locality, Khartoum, Sudan. Methods: A cross-sectional study was conducted between January and August 2020. Data were collected using a structured questionnaire. Satisfaction was estimated using the Likert Scale. The association between patient’s satisfaction and patient care indicators, namely: average dispensing time, percentage of medicine dispensed and labelled, and patient correct dose knowledge were assessed using Chi- square test, where a p-value < 0.05 was considered significant. Results: Out of 378 participants, the mean age was 47 with a comparable frequency of male and female participants (49.3% and 50.7% respectively). The mean satisfaction was 62.2% (3.11 ± 0.68). Most of the participants were satisfied with the way the pharmacist dealt with them (3.7, ± 0.778), while a low mean of satisfaction was reported regarding the availability of medicine within the pharmaceutical benefit package (2.06, ± 1.17). Average dispensing time was 5.78 minutes (p = 0.002), a low percentage of medicine actually dispensed and labelled was observed at 67% and 58% respectively (p = 0.00). A higher patient knowledge was reported 96.6% (p = 0.00), and the majority of the patients were able to pay 65% (p = 0.00). Conclusion: The current study demonstrates a comparable satisfaction score. However, medication unavailability is the main factor that affects patient satisfaction.
Effect of a collaborative multidimensional approach versus usual care on the resolution of adult depression in primary care in Chile: study protocol for a single blinded cluster randomized controlled trial
Authors: VITRIOL VERONICA , CANCINO ALFREDO , SCIOLLA ANDRES , GUIÑEZ SERGIO , CALVO JORGE , ORMAZABAL MARCELA , KREITHER JOHANNA , BALLESTEROS SOLEDAD , AYLWIN MARIA DE LA LUZ 
Published: February 2022

Background: Major depression (MD) is a prevalent and disabling condition in Chile. Most MD cases are treated at the primary care level. In Chilean primary care, the authors have gathered evidence of a prevalent complex depression subtype associated with a worse prognosis and characterized by interpersonal difficulties, suicidality and trauma history. This MD presentation suggests the need for a multidimensional, trauma-informed and interprofessional approach. The present study protocol describes the context, hypotheses and methods for a cluster randomized control trial (RCT) comparing a collaborative multidimensional approach and usual care in treatment outcomes of MD in primary care in Chile. Methods: This is a two-arm, single-blinded, cluster RCT to compare the efficacy of a collaborative multidimensional approach for depression (CMAD) versus usual care to treat MD in primary care clinics in Chile. In total, 394 depressed adults from 18 to 65 years of age in twelve clinics located in Chile’s Maule Region will be consented to participate in the study. Patients and care teams from each clinic will be randomized to the intervention or to the control arm. Interprofessional teams in the intervention arm will attend 27 hours of didactic and active learning sessions focused on clinical competences to effectively engage, treat and follow up patients with complex presentation of MD. Team in the control arm will receive 27 didactic sessions on current clinical guidelines for MD, professionals in both arms will receive 27 hours of continued education. Discussion: To improve treatment outcomes of MD in Chile, primary care teams should develop clinical competencies relevant to complex, difficult-to-treat types of MD within collaborative and trauma-informed approaches.
Beliefs on social distancing and face mask practices during the COVID-19 pandemic in low- and middle-income countries: a cross-sectional study
Authors: Harapan Harapan , Yufika Amanda , Anwar Samsul , Ophinni Youdiil , Yamada Chika , Sharun Khan , Gachabayov Mahir , Fahriani Marhami , Husnah Milda , Raad Rawan , Khiri Namareg ME. , Abdalla Rashed YA , Kacem Wajdi , Teyeb Zeineb , Aloui Khaoula , Ferjani Manel , Deeb Dalia A. , Emad Dina , Abbas Kirellos S , Panchawagh Suhrud , Anandu Sunil , Haque Md Ariful , Ferreto Lirane ED. , Briones María FC. , Morales Rocío BI. , Lazcano-Díaz Sebastián , Durosinmi Abiodun , Adejumo Esther N. , Babadi Elham , Kakemam Edris , Ullah Irfan , Malik Najma I. , Rosiello Francesco , Emran Talha B. , Nainu Firzan , Wendt Guilherme W. , Arab-Zozani Morteza , Wagner Abram L. , Mudatsir Mudatsir 
Published: February 2022

Introduction: Social distancing and wearing a face mask are highly recommended to mitigate the transmission of coronavirus disease 2019 (COVID-19). However, the success of these strategies relies on individuals’ adherence and public compliance. This study was conducted to assess the level of belief in social distancing and face mask practices in communities in low- and middle-income countries (LMICs) and to identify their possible determinants. Methods: A cross-sectional study was conducted in ten LMICs countries in Asia, Africa, and South America from February to May 2021. A questionnaire was used to assess the belief, practice, and their plausible determinants. Identification of the associated determinants was performed using a logistic regression model. Results: Our data revealed that only 62.6% and 66.9% of the participants had good beliefs in social distancing and good face mask practices, respectively. Residing in the Americas, having a healthcare-related job, knowing people in immediate social environment who are or have been infected and exposure to information of COVID-19 cases on social media or TV were factors significantly associated with good belief in social distancing. Residing country, gender, monthly household income, type of job and exposure to information of COVID-19 cases were significantly associated with face mask wearing practice. Conclusion: The proportion of participants having good beliefs in social distancing and good face mask practices is relatively low (<75%). Hence, sustained health campaigns regarding social distancing benefits and face mask-wearing practices during COVID-19 are critical in LMICs.
Cultural Heritage of Lemkos as a Research Problem in the Humanities and the Topic of Discourse in Poland
Authors: Zięba Andrzej A. 
Published: February 2022

Cultural Heritage of Lemkos as a Research Problem in the Humanities and the Topic of Discourse in Poland
The cultural heritage of Lemkos is today one of those European values that have found themselves in danger. The reason for this is not only the project of political and economic unification of Europe, which will inevitably trigger far-reaching cultural unification and violate ethnic and national traditions in its area, but also an event from over 80 years ago – the displacement of Lemkos from their homeland and the dispersion and assimilation in a different ethnic environment, as well as the destruction of material and spiritual heritage on the territory of this homeland and its resettlement by newcomers inheriting an alien culture. Among the many issues that come with it, two are the subject of this review. The first are the attitudes of Poles towards the Lemko heritage, which are reflected in the public discourse understood here not only as statements, but also as initiatives. The importance of this issue stems from the fact that the fate of the Lemko heritage is decided primarily within the context of contemporary Polish culture, although it is justified to disagree with the common identification of Poland with the communist authors and performers of the action of 1947, which destroyed the Lemko region as a homogeneous cultural area. The second issue is the way of analyzing the fate of this heritage in the humanities, wchich is devoid of a comparative perspective. It dominates today, narrowing research horizons as well as exerting a tangible influence on the choice of strategies for rescuing and transmitting endangered cultural content. In this regard, attention should be paid to the need to learn about and compare analogous cultural catastrophes caused by communist totalitarianism, as well as the strategies of survival and rebirth of the destroyed cultures.
Golfers have a greater improvement in their hip specific function compared to non-golfers after total hip arthroplasty, but less than three-quarters returned to golf
Authors: Robinson Patrick G. , Khan Shujaa , MacDonald Deborah , Murray Iain R. , Macpherson Gavin J. , Clement Nick D. 
Published: February 2022

AimsGolf is a popular pursuit among those requiring total hip arthroplasty (THA). The aim of this study was to determine if participating in golf is associated with greater functional outcomes, satisfaction, or improvement in quality of life (QoL) compared to non-golfers.MethodsAll patients undergoing primary THA over a one-year period at a single institution were included with one-year postoperative outcomes. Patients were retrospectively followed up to assess if they had been golfers at the time of their surgery. Multivariate linear regression analysis was performed to assess the independent association of preoperative golfing status on outcomes.ResultsThe study cohort consisted of a total of 308 patients undergoing THA, of whom 44 were golfers (14%). This included 120 male patients (39%) and 188 female patients (61%), with an overall mean age of 67.8 years (SD 11.6). Golfers had a greater mean postoperative Oxford Hip Score (OHS) (3.7 (95% confidence interval (CI) 1.9 to 5.5); p < 0.001) and EuroQol visual analogue scale (5.5 (95% CI 0.1 to 11.9); p = 0.039). However, there were no differences in EuroQoL five-dimension score (p = 0.124), pain visual analogue scale (p = 0.505), or Forgotten Joint Score (p = 0.215). When adjusting for confounders, golfers had a greater improvement in their Oxford Hip Score (2.7 (95% CI 0.2 to 5.3); p < 0.001) compared to non-golfers. Of the 44 patients who reported being golfers at the time of their surgery, 32 (72.7%) returned to golf and 84.4% of those were satisfied with their involvement in golf following surgery. Those who returned to golf were more likely to be male (p = 0.039) and had higher (better) preoperative health-related QoL (p = 0.040) and hip-related functional scores (p = 0.026).ConclusionGolfers had a greater improvement in their hip-specific function compared to non-golfers after THA. However, less than three-quarters of patients return to golf, with male patients and those who had greater preoperative QoL or hip-related function being more likely to return to play. Cite this article: Bone Jt Open 2022;3(2):145–151.