bluuebunny/crossref_metadata_2025_split huggingface dataset:
Angiotensin II type-1 receptor-associated protein interacts with transferrin receptor-1 and promotes its internalization
Authors: Abe Eriko , Yamashita Akio , Hirota Keigo , Yamaji Takahiro , Azushima Kengo , Urate Shingo , Suzuki Toru , Tanaka Shohei , Taguchi Shinya , Tsukamoto Shunichiro , Uehara Tatsuki , Wakui Hiromichi , Tamura Kouichi , Takahashi Hidehisa 
Published: October 2022

AbstractKidney fibrosis is a common pathway that leads to chronic kidney disease. Angiotensin II type-1 receptor (AT1R)-associated protein (ATRAP) was originally identified as an AT1R-binding protein. Previously, we reported that systemic knockout of ATRAP exacerbates kidney fibrosis in aged mice. Although these effects of ATRAP appeared to be AT1R-independent actions, the molecular mechanism remains poorly understood. To elucidate the molecular mechanism of ATRAP independent of AT1R, we explored novel ATRAP-interacting proteins. Mass spectrometric analysis of the immunoprecipitants of a Flag-tagged ATRAP complex revealed 376 candidate proteins that potentially interact with ATRAP. Gene ontology analysis revealed that proteins related to vesicle trafficking, membrane transport, and many membrane proteins, including transferrin receptor 1 (TfR1), were enriched. Because TfR1 promotes cellular iron uptake and iron is a key factor involved in kidney fibrosis, we focused on TfR1 and confirmed that it interacts with ATRAP. In addition, our findings revealed that enhanced ATRAP expression decreased cell-surface TfR1 expression without altering the overall cellular TfR1 expression levels. Furthermore, enhanced ATRAP expression attenuated cellular iron levels. Together, our results highlight the role of ATRAP as a suppressor of TfR1 that functions by facilitating TfR1 internalization, which affects iron metabolism and oxidative stress signaling.
Changes in metamorphopsia following intravitreal aflibercept injection for diabetic macular edema
Authors: Murakami Tomoya , Okamoto Fumiki , Sugiura Yoshimi , Morikawa Shohei , Okamoto Yoshifumi , Hiraoka Takahiro , Oshika Tetsuro 
Published: October 2022

AbstractThe aim of the present study was to investigate changes in metamorphopsia in patients with diabetic macular edema (DME) following intravitreal aflibercept injection (IVA) with the treat and extend (TAE) regimen for a year. We performed a post hoc analysis of a multicenter, open-label, single-arm, prospective study. The study included 20 patients with DME. All eyes received 3 monthly loading injections of 2 mg aflibercept, followed by a TAE regimen. Every visit, the severity of metamorphopsia and the best-corrected visual acuity (BCVA) were evaluated, and optical coherence tomography (OCT) images were obtained. The severity of metamorphopsia was measured using M-CHARTS. The metamorphopsia scores before treatment and at 1, 2, 3, 6 and 12 months following treatment were 0.25 ± 0.23, 0.21 ± 0.15, 0.19 ± 0.23, 0.14 ± 0.16, 0.17 ± 0.20 and 0.10 ± 0.17, respectively, with significant improvement from before treatment to 3 and 12 months following treatment (p < 0.05 and p < 0.005, respectively). At the time of macular edema resolution, the presence of an epiretinal membrane (ERM) was associated with the metamorphopsia score (p < 0.05). In conclusion, the metamorphopsia score in patients with DME improved following IVA with the TAE regimen for one year. The presence of ERM was associated with the metamorphopsia score.
Kir2.1 dysfunction at the sarcolemma and the sarcoplasmic reticulum causes arrhythmias in a mouse model of Andersen–Tawil syndrome type 1
Authors: Macías Álvaro , González-Guerra Andrés , Moreno-Manuel Ana I. , Cruz Francisco M. , Gutiérrez Lilian K. , García-Quintáns Nieves , Roche-Molina Marta , Bermúdez-Jiménez Francisco , Andrés Vicente , Vera-Pedrosa María Linarejos , Martínez-Carrascoso Isabel , Bernal Juan A. , Jalife José 
Published: October 2022

AbstractAndersen–Tawil syndrome type 1 (ATS1) is associated with life-threatening arrhythmias of unknown mechanism. In this study, we generated and characterized a mouse model of ATS1 carrying the trafficking-deficient mutant Kir2.1Δ314-315 channel. The mutant mouse recapitulates the electrophysiological phenotype of ATS1, with QT prolongation exacerbated by flecainide or isoproterenol, drug-induced QRS prolongation, increased vulnerability to reentrant arrhythmias and multifocal discharges resembling catecholaminergic polymorphic ventricular tachycardia (CPVT). Kir2.1Δ314-315 cardiomyocytes display significantly reduced inward rectifier K+ and Na+ currents, depolarized resting membrane potential and prolonged action potentials. We show that, in wild-type mouse cardiomyocytes and skeletal muscle cells, Kir2.1 channels localize to sarcoplasmic reticulum (SR) microdomains, contributing to intracellular Ca2+ homeostasis. Kir2.1Δ314-315 cardiomyocytes exhibit defective SR Kir2.1 localization and function, as intact and permeabilized Kir2.1Δ314-315 cardiomyocytes display abnormal spontaneous Ca2+ release events. Overall, defective Kir2.1 channel function at the sarcolemma and the SR explain the life-threatening arrhythmias in ATS1 and its overlap with CPVT.
Chronic allergic asthma alters m6A epitranscriptomic tagging of mRNAs and lncRNAs in the lung
Authors: Ni Xiuqin , Li Xing , Hu Bing , Wang Li 
Published: October 2022

Abstract
To evaluate the role of m6A methylation of mRNAs and long non-coding RNAs (lncRNAs) in chronic allergic asthma. Transcriptome-wide N6-methyladenosine (m6A) changes in BALB/c mice were profiled using immunoprecipitated methylated RNAs with microarrays in lung with chronic allergic asthma. Gene ontology (GO) and KEGG analyses were conducted. Target genes were verified by methylated RNA immunoprecipitation and real-time polymerase chain reaction (PCR). Specifically, the mRNA levels of m6A writers (METTL3, METTL14, and WTAP), and readers and erasers (FTO and ALKBH5) were estimated by real-time PCR analysis, using the SYBR-green method. IL17RB mRNA was also evaluated by PCR. Hematoxylin and eosin (H&E) staining showed that the airway and lung tissues in mice in the asthma group had extensive infiltration of inflammatory cells around the bronchioles, blood vessels, and alveoli. The lungs of those allergic asthma mice showed altered m6A epitranscriptome, whereby 1369 mRNAs and 176 lncRNAs were hypermethylated, and 197 mRNAs and 30 lncRNAs were hypomethylated (&gt;1.5-fold vs control). Also, compared with the control group, IL17RB mRNA in lung of the asthmatic group was significantly hypermethylated (P&lt;0.01). In the asthma group, the mRNA and the protein level of METTL14 (the key methyltransferase) and ALKBH5 (the major demethyltransferase) were significantly decreased compared with the control group (P&lt;0.01). Chronic allergic asthma alters the lung m6A epitranscriptome, suggesting functional implications in the pathophysiology of refractory asthma. Data support methylated IL17RB mRNA possibly becoming a new therapeutic target for chronic allergic asthma.
A hierarchical approach for P2P energy trading considering community energy storage and PV‐enriched system operator
Authors: Gokcek Tayfur , Sengor Ibrahim , Hayes Barry P. , Erdinc Ozan 
Published: October 2022

AbstractThe requirements to reduce dependence on fossil fuels and minimize harmful emissions necessitate using renewable energy more effectively. In this regard, a Peer‐to‐Peer (P2P) energy trading market in which excess power is sold to neighbors is emerging in place of the typical market where excess power is sold back to the grid. In this study, a bi‐level optimal bidding strategy is proposed in which community energy storage systems (CES) and community photovoltaic (CPV) generation are considered. Moreover, individual PV and CES are taken into account for each household. While optimal scheduling of prosumers is carried out at the lower level, the local clearing price considering the profit of Energy Sharing Provider (ESP) is obtained at the upper level. Furthermore, various case studies consisting of Peer‐to‐Grid (P2G), P2P, and CES‐supported P2P are created under different storage capacities. The devised mixed‐integer linear programming (MILP) based model is tested using each case study, validating the proposed model and proving its effectiveness.
A physics‐informed learning technique for fault location of DC microgrids using traveling waves
Authors: Paruthiyil Sajay Krishnan , Bidram Ali , Reno Matthew J. 
Published: October 2022

AbstractFast and accurate fault location in DC power systems is of particular importance to ensure their reliable operation. One of the approaches for implementing a fast‐tripping protection scheme is to use Traveling waves (TW) initiated by a fault scenario. This paper proposes a physics‐informed machine learning approach that utilizes TWs for fault location in DC microgrids. TWs are extracted by the so‐called multiresolution analysis which identifies the TW's wavelet coefficients for multiple frequency ranges. This paper deploys Parseval's theorem to find the energy of wavelet coefficients as a quantitative metric for describing TWs. The hypothesis of this paper is that once the Parseval energy curves for a specific cable are extracted, they can be utilized to locate faults along with that cable regardless of the DC system in which the cable is deployed. The fault location algorithm uses Parseval energy curves to train a Gaussian Process (GP) estimator. With the Parseval energy values of measured current at the protection device location, the GP estimator is able to estimate fault locations with high accuracy. The effectiveness of the proposed algorithm is verified by simulating a DC microgrid system in PSCAD/EMTDC.
Multiple discharges before leader inception in long air gaps under positive switching impulses
Authors: Zhao Xiangen , Lee Juhyeong , Liu Gang , Jia Lei , Liu Yang , He Junjia , Du Yaping 
Published: October 2022

AbstractThere are multiple corona bursts before leader inception when the rising rate of the applied voltage or electric field is not sufficiently high enough in long positive sparks. In existing studies, no attention has been paid to whether these corona bursts occur in the same location, and they are mostly considered directly as belonging to the same discharge. However, this paper presents that in a typical rod‐plate long air gap, the multiple corona bursts before leader inception are distributed in at least two different locations, and the highest probability of three discharges occurs. Also, the discharge occurs with the highest probability in the time sequence ‘tip‐tip‐side‐tip‐other side’ of the electrode in the first five corona bursts. For each discharge, the first corona current is a single, double exponential pulse, while the following corona currents are mostly a superposition of multiple pulses. The above findings are mainly based on experiments in a 1.4 m air gap under positive switching impulses, in which the voltage, current, and high‐speed images were recorded simultaneously. Finally, based on the experimental results, this paper discusses the effects brought by ignoring the multiple discharges on key parameters of leader inception and makes some suggestions to optimise long spark experiments.
Dynamically adaptive adjustment loss function biased towards few‐class learning
Authors: Liu Guoqi , Bai Lu , Li Junlin , Li Xusheng , Ru Linyuan , Chang Baofang 
Published: October 2022

AbstractConvolution neural networks have been widely used in the field of computer vision, which effectively solve practical problems. However, the loss function with fixed parameters will affect the training efficiency and even lead to poor prediction accuracy. In particular, when there is a class imbalance in the data, the final result tends to favor the large‐class. In detection and recognition problems, the large‐class will dominate due to its quantitative advantage, and the features of few‐class can be not fully learned. In order to learn few‐class, batch nuclear‐norm maximization is introduced to the deep neural networks, and the mechanism of the adaptive composite loss function is established to increase the diversity of the network and thus improve the accuracy of prediction. The proposed loss function is added to the crowd counting, and verified on ShanghaiTech and UCF_CC_50 datasets. Experimental results show that the proposed loss function improves the prediction accuracy and convergence speed of deep neural networks.
Design and multi‐disciplinary computational investigations on PVEH patches attached horizontal axis hybrid wind turbine system for additional energy extraction in HALE UAVs
Authors: Raja Vijayanandh , AL‐bonsrulah Hussein A. Z. , Raji Arul Prakash , Madasamy Senthil Kumar , Ramaiah Manivel , Gnanasekaran Raj Kumar , Kulandaiyappan Naveen Kumar , Al‐Bahrani Mohammed 
Published: October 2022

AbstractUnmanned Aerial Vehicles (UAVs) and their allies have dramatically increased aerospace's energy needs. To meet this need, hybrid power systems and extensive power utilization evaluations must be developed. This research focuses on energy and exergy‐based studies of hybrid wind power systems for fixed‐wing UAVs, which depend on wind turbines and piezoelectric patches. The proposed hybrid wind turbine is planned to be located at the fixed‐wing UAVs' rear position. The wind turbine was initially conceived and built using analytical methods and CAD tools based on power input. The wind turbine's CFD has produced the desired aerodynamic pressures and temperatures, torque, and power. Wind turbine exergy efficiencies have been determined using standard and specialized methods. Wind turbine blades are also patched with PVEH patches to generate hybrid electricity from renewable sources. CFRP‐UD‐Prepreg, CFRP‐Woven‐Prepreg, GFRP‐FR‐4‐Fabric, GFRP‐S‐UD, GFRP‐E‐Fabric, and KFRP‐49‐UD are the lightweight materials used in this work. PVEH patches, along with wind turbines, have been studied for energy and exergy. Modern engineering methods have shown that the proposed hybrid system is better suited to meet high power requirements. Based on this system, the wind turbine system is 0.39226 and the PVEH patches are 0.28131. Finally, aeroacoustic, vibrational, and structural studies are computationally analyzed.
Zur medizinischen Indikation bei ästhetisch-plastischen
Operationen
Authors: Allert Sixtus , Germann Günter 
Published: October 2022

ZusammenfassungDer Begriff der Indikation wird in der Medizin und in der Gesundheitswirtschaft
vielfältig gebraucht. Oft in Verbindung mit
„medizinisch“ und/oder
„ärztlich“ wird zumeist der Weg zwischen Arzt und
Patient beschrieben, nach Abwägung aller vorhandenen Informationen ein
gemeinsames Behandlungsziel zu beschreiben und daraus abgeleitete
Maßnahmen zu definieren. Aus heutiger Sicht spielt allerdings noch ein
dritter Faktor eine Rolle: die Gesundheitswirtschaft, hier insbesondere in Form
der Krankenversicherungen (sowohl GKV als auch PKV), aber neuerdings auch in
Form der Finanzverwaltungen. In der Plastischen Chirurgie zeigt sich das
Dilemma, dass trotz in vielen Fällen aus ärztlicher Sicht
gesicherter Indikation weder die Kostenträger noch Finanzgerichte oder
-ämter bereit sind, der ärztlichen Einschätzung zu
folgen und die Indikationsstellung (zumeist ohne Begründung) ablehnen.
Die Arbeit bietet Hilfestellung zur Definition einer Indikation bei
ästhetisch plastischen Eingriffen.
Improving Tobacco Cessation Rates Using Inline Clinical Decision Support
Authors: Drake Lauren A. , Suresh Krithika , Chrastil Hillary , Lewis Carmen L. , Altman Richard L. 
Published: October 2022

Abstract
Background Tobacco use is a significant cause of morbidity and mortality in the United States. Even brief advice from a clinician can significantly influence cessation rates among tobacco users, but clinicians often miss opportunities to provide this simple intervention.
Objectives The intent of this quality improvement project was to increase tobacco cessation among tobacco users by nudging clinicians using a clinical decision support (CDS) tool.
Methods We developed a CDS tool using principles of user-centered design and the CDS Five Rights to dynamically insert actionable information about current tobacco users into the Assessment and Plan section of clinicians' notes. We conducted a retrospective analysis of patients at four primary care practices in the Denver Metro area evaluating the impact of the CDS tool on time to tobacco cessation. A multivariable Cox proportional-hazards model was used in this determination. Kaplan–Meier curves were used to estimate tobacco cessation probabilities at 90, 180, and 365 days.
Results We analyzed 5,644 patients with a median age of 45 years, most of whom lived in an urban location (99.5%) and the majority of whom were males (60%). The median follow-up time for patients was 16 months. After adjustment for age, gender, practice site, and patient location (rural, urban), the intervention group had significantly greater risk of tobacco cessation compared to those in the control group (hazard ratio: 1.22, 95% confidence interval: 1.08–1.36; p = 0.001).
Conclusion This study suggests a CDS intervention which respects the CDS Five Rights and incorporates user-centered design can affect tobacco use rates. Future work should expand the target population of this CDS tool and continue a user-centered, iterative design process.
Oblique Angled Retractor for Lumboperitoneal Shunt Implantation via Lateral Abdominal Laparotomy
Authors: Yokoya Shigeomi , Oka Hideki 
Published: October 2022

Abstract
Background A normal retractor often interferes with the ribs and/or thighs of the ipsilateral side when the skin and abdominal muscles are towed while performing the lumboperitoneal shunt (LPS) procedure in the lateral position. To overcome this, we developed an obtuse-angled retractor.
Methods We modified the traditional retractors into oblique-angled retractors. The blade of the new retractors was bent to 60 degrees, the entire blade was thinned, and the tip of the blade was tapered.
Results To date, we have performed approximately 30 LPS procedures in the lateral position using the new oblique-angled retractor and confirmed its usefulness.
Conclusion An oblique-angled retractor helps confirm the accurate placement of the tip of the retractor blades, even in obese patients in whom the retractor often interferes with the ribs and/or thighs.
Piezoelectric Actuator-Driven Pulsed Water Jet for Neurosurgery: Laboratory Evaluation with the Swine Model and Implications of Mechanical Properties
Authors: Nakagawa Atsuhiro , Endo Toshiki , Kawaguchi Tomohiro , Yamada Masato , Sato Chiaki , Kumabe Toshihiro , Iwasaki Masaki , Niizuma Kuniyasu , Kanamori Masayuki , Nakanishi Chikashi , Yamashita Shinichi , Nakano Toru , Tominaga Teiji 
Published: October 2022

Abstract
Background Pulsed water jet is an emerging surgical instrumentation intended to achieve both maximal lesion resection and functional maintenance through preservation of fine vessels and minimal damage to the surrounding tissue. The piezoelectric actuator-driven pulsed water jet (ADPJ) is a new technology that can deliver a precisely controlled uniform and efficient pulsed water jet with minimum water flow. The present study evaluated the ADPJ system in preclinical animal studies in the swine brain, and investigated breaking strength, one of the parameters for mechanical properties, to elucidate the mechanism of tissue selectivity for tissue dissection by the water jet.
Methods This system consisted of a pump chamber driven by a piezoelectric actuator, a stainless steel tube, and a nozzle (internal diameter: 0.15 mm). Water was supplied at 6 ml/min. The relationship between input voltage (3–25 V at 400 Hz) and peak pressure was measured using a pressure sensor through a sensing hole. The temporal profile of dissection depth during moving application was evaluated using gelatin brain phantom and swine brain. The dissected specimens were evaluated histologically. The mechanical property (breaking strength) of the swine brain was measured by a compact table-top universal tester.
Results Peak pressure increased linearly with increase in input voltage, which reflected the dissection depth in both the gelatin brain phantom and swine brain. Small arteries were preserved, and minimum damage to surrounding tissues occurred. The breaking strength of the arachnoid membrane (0.12 ± 0.014 MPa) was significantly higher compared with the gray matter (0.030 ± 0.010 MPa) and white matter (0.056 ± 0.009 MPa; p < 0.05). The breaking strength of the gray matter corresponded to that of 3 wt% gelatin, and that of white matter corresponded to a value between 3.5 and 4 wt% gelatin, and the dissection depth seemed to be estimated at 3 to 4 wt% gelatin.
Conclusion The present study suggests that the ADPJ system has the potential to achieve accurate tissue dissection with preservation of blood vessels in neurosurgery. The difference in breaking strength may explain the tissue selectivity between the brain parenchyma and tissue protected by the arachnoid membrane.
Hidden policy conflicts? Administrative strategies to manage depoliticisation
Authors: Skoog Louise , Svensson Petra 
Published: October 2022

AbstractAs a way to manage political disagreements over public policies, political representatives might be tempted to avoid open discussions by depoliticising political issues—hoping that the conflict may eventually disappear. When decision-makers employ such strategies, it is up to the administration to make political priorities and manage unresolved policy conflicts. Earlier studies indicate that there are at least two strategies that administrators can employ to manage such ambiguities: (re)framing and technical depoliticisation. This article reveals that public administrators also employ a third framing strategy: repoliticisation, where administrators seek to endow their policy areas with political power by connecting politicians to the work and implementation of policies. The study is based on 38 interviews from 11 municipalities in Sweden.
Comparison of Langmuir probe and optical emission spectroscopy on a volume-cusp filament ion source using helium
Authors: Savard N. , Fubiani G. , Dehnel M. 
Published: October 2022

D-Pace has a Penning ion source that runs with helium for studies of α-particle production. We want to study its plasma properties as a function of varying operational parameters, which results in varied output ion beam characteristics. In order to diagnose the ion source plasma, a collisional-radiative code for helium to be used with optical emission spectroscopy measurements is developed. This has the advantage of being non-invasive, which allows for measurements using the emitted light from the plasma. This collisional-radiative code is shown to compare well with the Yacora on the Web model developed at IPP-Garching, and improves upon it with the addition of radiation trapping. Furthermore, the sensitivity of this model to the inclusion of additional excited state populations and non-Maxwellian electron energy distribution functions is investigated. It is shown that non-Maxwellian distributions can significantly affect spectroscopy measurements. This diagnostic is benchmarked to Langmuir probe measurements on the TRIUMF-licensed volume-cusp ion source to determine whether it can replicate the measured electron density and electron temperature as a function of varied operational parameters. The operational parameters are helium gas flow (10–40 SCCM), arc voltage (100–200 V), and arc current (1–5 A). The measured plasma properties, while different in absolute value, have similar trends for each operational parameter except when varying arc voltage. It is shown that this mismatch as a function of arc voltage is likely due to high energy non-Maxwellian electrons from the cathode sheath, which are not included within the collisional-radiative model.