bluuebunny/crossref_metadata_2025_split huggingface dataset:
Label Propagation Based on Bipartite Graph
Authors: Li Yaoxing , Bai Liang 
Published: October 2022

Abstract
Label propagation is a popular graph-based semi-supervised learning framework. Its effectiveness depends on the distribution of prior labels. If there are no objects with prior labels in parts of classes, the label propagation has a very bad performance. To get rid of this deficiency, we propose a label propagation based on bipartite graph algorithm. In this algorithm, we try to learn a bipartite graph as exemplar constraints that reflect the relations between objects and exemplars representing all the classes to guide the learning process, instead of label constraints in original label propagation. We provide a method to produce high-quality exemplars from two channels representing the known classes (where some objects have prior labels) and the missing classes (where all the objects have no prior labels), respectively. Based on the generated exemplars, the exemplar constraints can be learned by using relations in the known classes to evaluate that in the missing classes. Compared to other existing versions of the LP algorithms , we use different experiments to prove that the proposed algorithm can effectively overcome the label missing problem in some classes.
Preferred Z-Complementary Pairs and Their Application in Doppler Resilient Waveform Design
Authors: Shen Bingsheng , Yang Yang , Fan Pingzhi 
Published: October 2022

Abstract
Z-complementary pairs (ZCPs) are well-known, but few work has dedicated to their aperiodic cross-correlation. One objective of this paper is to propose a novel class of sequence pairs, called ``preferred Z-complementary pairs (PZCPs)'', where each sequence pair has Z-complementary property, and the aperiodic cross-correlation between the two sequences in each pair are zeros within a certain region. Some constructions of PZCPs from Golay complementary pairs (GCPs) are presented. Another objective of this paper is to apply PZCPs to design Doppler resilient waveforms combined with equal sums of powers (ESPs). Simulation results show that the proposed waveform has good Doppler tolerance.
Mathematics Subject Classification (2000) 06E30 · 11T71 · 94A60
Social Determinants of Multimorbidity Patterns in South Spain: Findings from the DEMMOCAD project
Authors: Carretero-Bravo Jesús , Ramos-Fiol Begoña , Ortega-Martín Esther , Suarez-Lledo Víctor , Salazar-Couso Alejandro , O’Ferrall-González Cristina , Dueñas-Rodríguez María , Peralta-Sáez Juan Luis , González-Caballero Juan Luis , Cordoba-Doña Juan Antonio , Lagares-Franco Carolina , Martínez-Nieto José Manuel , Almenara-Barrios José , Álvarez-Gálvez Javier 
Published: October 2022

Abstract
Multimorbidity is a growing challenge, associated with reduced quality of life, increased disability, increased health care utilisation, and increased mortality. There is a need to identify associations among patterns of chronic conditions and social determinants of health in the local context of specific population groups. This work aims to respond to this gap, detecting patterns of multimorbidity and their inequalities in the province of Cadiz (South Spain). A cross-sectional study was conducted through a telephone interview in population over 50 years of age. We use Latent Class Analysis to identify patterns from 31 health chronic conditions and to detect associations with social determinants. The model derived five patterns, with an entropy of 0.728, which were as follows: ‘Relative Healthy’, ‘Cardiovascular’, ‘Musculoskeletal’, ‘Musculoskeletal and Mental’ and ‘Complex Multimorbidity’. Patterns showed significant differences in the covariates, with results in age, education, income level, and health services use being of particular interest. All four patterns with more conditions also showed lower scores on the two dimensions of SF12 scale. We also found significant differences among patterns and districts in Jerez. These results highlight the existence of social inequalities in multimorbidity at the local level that should be addressed by implementing policies targeting the most vulnerable social groups in Cadiz.
Trophoblast stem-cell-derived exosomes alleviate cardiotoxicity of Doxorubicin via improving Mfn2-mediated mitochondrial fusion
Authors: Duan Junfeng , Liu Xiaoli , Shen Song , Tan Xi , Wang Yi , Wang Lian , Kang Lina , Wang Kun , Wei Zhonghai , Qi Yu , Hu Lei , Xu Biao , Gu Rong 
Published: October 2022

Abstract
Doxorubicin (Dox) is an anticancer drug widely used with the side-effect of cardiotoxicity. The cardiotoxicity of Dox is closely related to mitochondrial damage. Mitochondrial dynamics is a quality control mechanism that usually helps to maintain a healthy mitochondrial pool. Trophoblast stem cell-derived exosomes (TSC-Exos) have been shown to protect cardiomyocytes from DOX-induced cardiotoxicity. To explore whether the cardioprotective role is mediated by the regulation of mitochondrial dynamic mechanism, we isolated TSC-Exos from human trophoblast stem cells by ultracentrifugation and characterized them by Western blot and transmission electron microscopy. We performed cellular experiments with H9c2 cells co-cultured with Dox and TSC-Exos in vitro, and in vivo we established a heart failure model by intraperitoneal injection of Dox. Mice in the treatment group were received additional intracardiac injection of TSC-Exos. Then, the cardiac function, cardiomyocyte apoptosis and mitochondrial fragmentation of the treatment group were ameliorated.Dox caused an increased tendency of mitochondrial fission, which was manifested by a decrease in the average size of mitochondria. By receiving TSC-Exos treatment, this effect was eliminated, and its downstream molecular mechanism was investigated. In summary, these results suggested that TSC-Exos lesson DOX-induced cardiotoxicity through antiapoptotic effect and improving mitochondrial fusion with an increase in Mfn2 expression. Together, this study provides a potential new treatment scheme of TSC-Exos for the treatment of heart failure.
Echocardiographic Estimation of Left Ventricular Filling Pressures in Heart Transplant Recipients
Authors: Rahbar Zohreh , Badkoubeh Roya Sattarzadeh , Bakhshandeh Alireza , Mehrpooya Maryam , Sardari Akram , Larti Farnoosh , Tavoosi Anahita 
Published: October 2022

Abstract
Purpose
LV diastolic dysfunction has often been described as a sensitive sign of early graft rejection. Assessment of left ventricular filling pressure by echocardiography in heart transplant (HTx) recipients is challenging. We aimed to investigate the ability of echocardiographic indices to detect elevated Left ventricular end-diastolic pressure (LVEDP) in HTx patients.
Methods
This descriptive cross-sectional study included 39 HTx recipients who were candidates for endomyocardial biopsy as a part of their routine post-transplantation surveillance. Doppler transthoracic echocardiography was done before the procedure, and left heart catheterization was done during the endomyocardial biopsy.
Results
Thirty-nine patients (15 female, 24 male), with the mean age of 39.6 years (range 13 to 70), were enrolled. A strong relation was observed between lateral E/e’ and LVEDP (R = 0.64, P-value < 0.001) and average E/e’ and LVEDP (R = 0.6, P-value < 0.001). The best cutoff value for LVEDP prediction was the average E/e’ ≥ 6.8 with a sensitivity of 96.15% and specificity of 68.5% for the prediction of LVEDP more than or equal to 20mmHg. Two predictive models comprising age, gender, and lateral E/e’ or average E/e’ were also proposed. A significant relationship was also found between LVEDP and left ventricular global longitudinal strain (R=-0.31, P-value < 0.01).
Conclusion
Lateral E/e’ was the best predictor of LVEDP. The cutoff of average E/e’ had the best validity for the estimation of LVEDP. Despite the strong observed association, echocardiographic parameters still cannot consider as a surrogate for invasive LVEDP measurements when seeking information about left ventricle filling pressure on heart transplant recipients.
Potential of Burkholderia sp. IMCC1007 as a biodetoxification agent in mycotoxin biotransformation evaluated by mass spectrometry and phytotoxicity analysis
Authors: Din Abd Rahman Jabir Mohd , Shadan Nor Hidayah , Rosli Mohamad Azzuan , Musa Nur Fashya , Othman Nor Zalina 
Published: October 2022

Abstract
Microbial degradation is considered as an attractive method to eliminate exposure to mycotoxin that cause a serious threat in agriculture global industry and severe human health problems. Compared with other more prominent mycotoxin compounds, fusaric acid (FA) biodegradation has not been widely investigated. In this study, a fusaric acid-degrading bacterium Burkholderia sp. IMCC1007 was identified by 16S rRNA gene sequencing and its detoxification characteristics were evaluated. This strain able to utilize FA as sole energy and carbon source with growth rate (µ) of 0.18 h− 1. Approximately 93% from the initial substrate FA concentration was almost degraded to the residual about 4.87 mg L− 1 after 12 h of incubation. The optimal degradation conditions for pH and temperature were recorded at 6.0 with 30°C respectively. An efficient FA degradation of strain IMCC1007 suggested its potential significance to detoxification development. Accroding to LC-MS/Q-TOF analysis, FA was bio-transformed to 4-hydroxybenzoic acid (C7H6O3) and other possible metabolites. Plant treated with detoxified FA products exhibited reduction of wilting index, mitigating against FA phytoxicity effect on plant growth and photosynthesis activity. Phytotoxicity bioassay suggested that degradation product of IMCC1007 was not a potent harmful compound towards plants as compared to the parent compound, FA. As a conslusion, our study provides a new insight into the practical application of biodetoxifcation agent in controlling mycotoxin contamination.
The impact of the initial and second national COVID-19 lockdowns on mental health in young people with and without pre-existing self-injury, suicide ideation, and ED symptoms
Authors: Danielsen Stine , Joensen Andrea , Andersen Per K , Madsen Trine , Strandberg-Larsen Katrine 
Published: October 2022

Abstract
Young people with pre-existing mental health problems were appointed as particularly vulnerable to deteriorations in mental health as consequences of the lockdowns, but solid evidence is limited. Using the Danish National Birth Cohort, we estimated changes in mental health from pre to during lockdown in 18-24-year-olds with versus without pre-existing self-injury, suicide ideation, and ED symptoms, respectively. Young people without pre-existing self-injury and suicide ideation experienced greater deterioration in quality of life and mental well-being and a higher proportion of loneliness compared to those without. The changes in mental health in people with versus without ED symptoms were more similar.
Combining skin and olfactory α-synuclein RT-QuIC - towards biomarker-driven phenotyping in synucleinopathies
Authors: Kuzkina Anastasia , Rößle Jonas , Seger Aline , Panzer Celine , Kohl Antonia , Maltese Virginia , Musacchio Thomas , Blaschke Stefan , Tamgüney Gültekin , Kaulitz Stefan , Rak Kristen , Scherzad Agmal , Zimmermann Philipp , Klussmann Jens , Hackenberg Stefan , Volkmann Jens , Sommer Claudia , Sommerauer Michael , Doppler Kathrin 
Published: October 2022

Abstract
Seeding assays, such as real-time quaking-induced conversion (RT-QuIC), are becoming commonly used in synucleinopathies to detect α-synuclein aggregates. Studies in Parkinson’s disease (PD) and isolated REM-sleep behavior disorder (iRBD) have shown a considerably lower sensitivity in the olfactory epithelium than in CSF or skin. To get an insight into α-synuclein (α-syn) distribution within the nervous system and reasons for low sensitivity, we compared RT-QuIC assessment of nasal brushings and skin biopsies in PD and iRBD patients and unaffected controls. We could show higher sensitivity of RT-QuIC in skin compared to nasal brushings and a higher deposition of misfolded α-synuclein across all sampled tissues in the iRBD cohort compared to PD, supporting the notion of RBD as a marker of a more malignant subtype of synucleinopathy. Interestingly, we identified a PD subgroup of patients with misfolded α-syn in the olfactory epithelium who did not show any dermal pathology, likely corresponding to the recently proposed brain-first subtype. Assaying α-syn of diverse origin (such as olfactory and peripheral nervous system) could allow better stratification of patients.
Acellular dermal matrix treats lower extremity full-thickness skin defect on one-stage without skin graft or flaps
Authors: Li Gongchi , Shen Qian , Zhou Pan , Liu Hanlin , Chen Jianghai 
Published: October 2022

Abstract
Background: Self-repair of lower limb wounds has always been one of the research hotspots. Flaps and skin graft are the preferred treatment for lower extremity wound reconstruction. However, these treatments have many disadvantages, such as secondary damage, poor healing quality. In recent years, the use of acellular dermal matrix has emerged as an alternative treatment option for extremity ulcers.
Methods: This study aimed to explore whether acellular dermal matrix can be used as a single treatment to promote wound healing. 7 patients with lower extremities cutaneous deficiency exposing bone or tendon, was covered by Pelnac, which was an acellular dermal matrix product approved by China Food and Drug Administration. All the wound was treated by Pelnac without flaps and skin graft. The external dressing was changed every 10 days.
Results: After a maximum of 20 weeks, all the wounds were completely healed. During the 12 months follow-up period none of the patients developed skin wear on the treatment area. All patients maintained their postoperative ambulatory ability. All patients were satisfied with the appearance and feeling after wound healing.
Conclusion: These findings may mean acellular dermal matrix is a novel method oﬀering opportunity for treatment of lower extremities cutaneous deficiency exposing bone or tendon. It also has the potential to close wounds of all uninfected, non-ischemic, full-thickness cutaneous deficiency.
Plastic Optical Fiber Angle Sensor for 1-D and 2-D Based On Cascading Of TMBC
Authors: Ghaffar Abdul , Chhattal Muhammad , Mehdi Mujahid , Ali Fayaz , Ali Sikandar , Ali Salamat 
Published: October 2022

Abstract
The developed angle sensors are usually used for either clockwise or an anti-clockwise direction. Here, we present a relatively new setup of two angle sensors (1-D and 2-D) for independent and simultaneous clock and anti-clockwise rotation measurements. The proposed sensor is based on the twisted macro-bend coupling method (TMBC), in which two fibers are twisted and bent. The two-angle sensors are presented in which sensor-1 consists of a single twisted bend and sensor-2 contain two twisted bends on a single transmitting fiber. The angle measurement relies on the coupling of macro-bend loss. The stepper motor is used to drag the twisted fiber, resulting in a change in the bending radius that increases or decreases the macro-bend loss. A novel cascading method is introduced in the TMBC method for the sensor-2 and, two stepper motors are used in the second experiment. To prove the practicality, several test scenarios are conducted for both sensor configurations. The experimental results show that sensor-1 can measure angle ±180º, whereas the full clock and anti-clockwise cycle are achieved through sensor-2, having a measurement range is ±360º. Therefore, the proposed sensor can be a potential means for accurate angle measurement in industrial applications.
Impact of Family Function on Mental Health Problems of College Students in China During COVID-19 Pandemic and Moderating Role of Coping Style: A Longitudinal Study
Authors: Liu Lili , Chen Jianbin , Liang Shunwei , Yang Wenwen , Peng Xiaodan , Cai Chengcheng , Huang Andi , Wang Xiayong , Zhao Jingbo 
Published: October 2022

Abstract
Background

During the COVID-19 pandemic, college students were required to stay at home and maintain social distancing the entire spring semester of 2020. There is little research on how family function influenced mental health problems and how coping styles moderated the relationship between family function and mental health problems among college students during their stay-at-home period.

Methods

We carried out four evaluations between February and October 2020 through an online survey. A total of 13,462 college students (age = 16–29 years) participated. Family function, coping styles, depression symptoms, and anxiety symptoms were studied. To evaluate the associations between variables, a generalized estimating equation was used.

Results

Findings indicate that the incidence rates of depression rose during stay-at-home period from 33.87%, 95% CI (29.88%, 38.10%) to 40.08% 95% CI (35.76%, 44.55%) after schools reopened, χ2 = 193.68, p < 0.001. The incidence rates of anxiety rose from 17.45%, 95% CI (14.59%, 20.73%) to 26.53%, 95% CI (16.94%, 23.67%) through the entire period, χ2 = 195.74, p < 0.001. The incidence rate of depression and anxiety for different family function groups varied at different time points, the interaction effect was significant (χ2 = 52.97, p < 0.001 and χ2 = 51.25, p < 0.001, respectively). The incidence rate of depression and anxiety for different family function groups with different coping styles also varied at different time points, the interaction effect was likewise significant (χ2 = 862.09, p < 0.001 and χ2 = 583.29, p < 0.001, respectively).

Conclusions

These findings shed light on how family function intersected with coping styles to influence the mental health problems of college students during and after the stay-at-home period of COVID-19. These findings highlight the importance of paying special attention to college students' family function and promoting appropriate coping strategies during and after COVID-19.
Impacts of dike systems on hydrological regime in Vietnamese Mekong Delta
Authors: Xuan Nguyen Van , Giang Nguyen Ngoc Long , Ty Tran Van , Kumar Pankaj , Downes Nigel K. , Nam Nguyen Dinh Giang , Ngan Nguyen Vo Chau , Thinh Lam Van , Duy Dinh Van , Avtar Ram , Thu Minh Huynh Vuong 
Published: October 2022

Abstract
This paper examines the impact of the dike systems on river flows in the Vietnamese Mekong Delta (VMD). The study combined a hydrological change index method and the Mann–Kendall test to assess the temporal dynamics of both discharge and water levels along the main rivers of the VMD. Results highlight that the system of rivers and canals helps facilitate waterway traffic and drainage during the flood season. However, the low elevation of the delta has created conditions suitable for saline water to increasingly penetrate upstream during the dry season. Observed changes in the hydrological indicators at the upstream stations of Tan Chau (Mekong River) and Chau Doc (Bassac River) are not only due to the dike system but also upstream alterations to the flow regime. More research is needed to consider the various drivers of flow-regime change associated with natural and human activities both inside and outside of the study area.
DPP-Cu2+ Complexes Gated Mesoporous Silica Nanoparticles For pH
and Redox Dual Stimuli-Responsive Drug Delivery
Authors: Chen Wei , Ma Mingyang , Lai Qingteng , Zhang Yanke , Liu Zhengchun 
Published: October 2022

Objective:
A simple pH and redox dual stimuli-responsive diketopyrrolopyrrole (DPP)-Cu2+ complexes gated mesoporous silica nanoparticles (MSN) were prepared for precise drug delivery and controlled drug release.

Methods:
MSN was prepared by sol-gel method and then laminated. Carboxylic acid (CA)-Pyrrolo[3,4-c] pyrrole-1,4-dione, 2,5-dihydro-3,6-di-2-pyridinyl (PyDPP) was grafted onto the surface of amino-functionalized MSN (MSN-NH2) through a simple amide reaction and then complexed with Cu2+ to form gated molecules after doxorubicin (DOX) loading.

Results:
Scanning electron microscopy (SEM), transmission electron microscopy
(TEM), and Low-angle X-ray diffraction (XRD) showed that MSN with uniform particle
size (100 nm) and porous structure was successfully prepared. The prepared MSN, MSN-
NH2, and MSN-DPP were fully characterized by Zeta potential, Fourier transforms infrared
spectroscopy (FTIR), X-ray photoelectron spectroscopy (XPS) and nitrogen adsorption-
desorption. High DOX-loading capacity (18.22%) and encapsulation efficiency
(89.16%) were achieved by optimizing the mass ratio of MSN to DOX. Release studies
showed that the gated molecules of our designed DPP-Cu2+ complexes had a good blocking
effect under physiological conditions (the cumulative release rate of drugs within 24
hours was only 4.18%) and responded well to the pH and redox glutathione (GSH) dual
stimuli. In vitro cytotoxicity assay showed that MSN-DPP-Cu2+ had good biocompatibility
in both Hep G2 cells and L02 cells (the relative cell viability of both cells within 48
hours was above 97%), and the MSN-DPP-Cu2+@DOX could be triggered for efficient
drug release in Hep G2 cells.

Conclusion:
The MSN-DPP-Cu2+ described in this research may be a good delivery system for the controlled release of antitumor drugs and can provide a potential possibility for clinical application in the future.
Prognostic Significance of ZP3 in Hepatocellular Carcinoma
Authors: Bi Yuanjian , Jin Song , Tang Guorong , Pan Dingquan , Song Xin , Zhu Xiaonian , Tan Shengkui 
Published: October 2022

Objective:
The study aims to explore the prognostic significance of zona pellucida glycoprotein 3 (ZP3) in hepatocellular carcinoma (HCC) tissues.

Methods:
The expression of ZP3 protein in HCC tissues was detected by immunohistochemistry (IHC) to study its effects on the clinicopathological characteristics and prognosis of HCC patients. The Cancer Genome Atlas (TCGA) database was used to confirm the expression of ZP3 in HCC tissues and Gene set enrichment analysis (GSEA) was performed to obtain potential ZP3-related pathways in HCC.

Results:
IHC detection found that ZP3 had a high expression in HCC tissues and was associated with cirrhosis, and hepatitis B virus infection of HCC patients (P<0.05). TCGA database also showed that ZP3 was up-regulated in HCC tissues. Further survival evaluation confirmed that ZP3 expression caused an impact on the overall survival time and disease-free survival time of HCC patients (P<0.05), implying a potential role in HCC prognosis. GSEA analysis indicated that the 187 differential gene sets were mainly involved in 10 signaling pathways, including 5 up-regulated and 5 down-regulated pathways.

Conclusion:
High expression of ZP3 in HCC tissues shows an important role in HCC development and prognosis.