bluuebunny/crossref_metadata_2025_split huggingface dataset:
Electrostatic Induced Peptide Hydrogels for pH‐Controllable Doxorubicin Release and Antitumor Activity
Authors: Tang Yuanhan , Lu Yingying , Li Lingyi , Shi Changxin , Zhang Xin , Li Xinyue , Niu Yuzhong , Liu Fangjie , Wang Linlin , Xu Wenlong 
Published: September 2022

AbstractDrug carriers can improve the accuracy of drug efficacy and release behaviors. As drug carrier, short peptide hydrogels have promising future since their good biocompatibility and mechanical properties. In this study, we reported a short peptide (FFWDD) that was used as drug carrier to encapsulate doxorubicin (DOX) hydrochloride by forming a drug‐loaded hydrogel. The prepared hydrogel has complex interlaced network structure and good mechanical strength that allows it to encapsulate the drug. The strong electrostatic interaction between FFWDD and DOX resulted in less release at pH 7.4 and high release at pH 5.5, which may reduce the side effect of DOX. Drug release kinetics showed release in both pH 7.4 and pH 5.5 is in accordance with the Makoid‐Banakar model (R2=0.9973 and 0.9964), reflecting the Non‐Fickian diffusion and Quasi‐Fickian diffusion release mechanism by the Korsmeyer‐Peppas model, respectively. CCK‐8 assays demonstrated the excellent biocompatibility of the peptide against human embryonic kidney cells (HEK293) and showed that the antitumor effect of the hydrogel to colon cancer LoVo cells was similar to that of the single DOX. DOX released from the drug delivery system could be taken up by tumor cells in large quantities and accumulate in the nucleus. This research has refined peptide hydrogels as drug carriers, which are expected to be used as drug carriers in biomedical applications.
Utilization of Photocatalysis and Pyroelectric Catalysis to Enhance Catalytic Properties in Pb(Zr0.52Ti0.48) O3 Nanocubes: A Study on Pyro‐/photo‐bi‐catalysis Degradation of Dye Wastewater
Authors: Zhao Yaru , Liu Zhifeng , Ruan Mengnan , Guo Zhengang 
Published: September 2022

AbstractPhoto‐generated carriers efficient separation and transportation are pivotal in determining the efficiency of photocatalysis technology. In this work, we utilize pyroelectric‐assisted photocatalysis to promote the effective separation of carriers of Pb(Zr0.52Ti0.48)O3 (PZT) nanocubes, and the degradation of dyes is realized under thermal gradient excitation and visible light irradiation. Under the conditions of 20–55 °C hot‐cold cycles and visible light, using the same PZT catalysts, the degradation rate of the pyro‐/photo‐bi‐catalysis is up to 95.09 %, much higher than 66.21 % or 11.41 % which are achieved by the conditions only photocatalytic or pyroelectric catalysis. It is found that the improvement in bi‐catalysis efficiency is not only because of the pyro‐generated and photogenerated carriers generation, but also on account of pyroelectric polarization promotes separation of photo‐induced carriers. These results indicate that pyroelectric PZT can degrade dye wastewater by using multiple clean energy sources such as solar energy and thermal energy simultaneously. The multiple fields superposition catalysis of PZT nanocubes is potential in the future application of dye wastewater treatment.
Beyond the Conventional Photodynamic Therapy by Water‐Soluble Phthalocyanines
Authors: Abdulcelil Yüzer Lecturer , Kübra Demircioglu Perihan , Derya Yetkin Lecturer , Ince Mine , Ayaz Furkan 
Published: September 2022

AbstractCompared to the classical chemotherapy applications, PDT applications are based on a non‐toxic compound that can be specifically activated by shining a certain wavelength of light. Constitituvely active chemotherapy drug agents lead to detrimental and unwanted side effects that halt the normal life standards of the cancer patients. Localized and controlled activation of the drug agents by PDT applications aims to overcome the side effects associated with the treatment. In our study we synthesized a unique set of phthalocyanine molecules that are water soluble to make them biocompatible. Moreover, these compounds anti‐cancer activities were measured from multiple angles. Anti‐cancer PDT activities of the derivatives were studied by testing their effects on the cell proliferation, apoptosis and cell cycle progression. Moreover, these derivatives anti‐metastatic, anti‐angiogenic and immunomodulatory photodynamic activities were comprehensively studied by focusing on the intracellular signaling pathways that may play important roles in carcinogenesis, angiogenesis, metastasis and immune reactions. For the first time to our knowledge we are presenting data beyond the classical or canonical PDT applications in which generation of the reactive oxygen species (ROS) is explained as the main mechanism of the action for the PDT applications. Our results suggest that non‐canonical PDT activity can be observed independent of the ROS generation efficiencies probably by affecting the intracellular signaling pathways. These novel set of phthalocyanine derivatives may find applications against colon, lung, breast and prostate cancer.
Ethanol Based Electrolyte for Ultra‐stable Zn/NiHCF Batteries
Authors: Wang Jiang , Duan Jingying , Zhang Yimin , Chen Mingming , Wang Chengyang 
Published: September 2022

AbstractPrussian blue analogs (PBAs) have attracted widespread attention as cathode materials for aqueous zinc ion batteries (AZIBs) in view of their open frameworks, adjustable redox sites, and high operating voltages. However, the poor cycling stability limits its practical application severely. Herein, the cubic K2NiFe(CN)6 (NiHCF) is prepared as the active cathode material for AZIBs. The cycling stability of the Zn/NiHCF battery is improved greatly just by simply replacing the H2O with ethanol (EA) as electrolyte solvent. Ex‐situ XRD and SEM characterizations reveal the stable morphology of NiHCF during charging/discharge process in the 0.5 M Zn(OTf)2‐EA electrolyte and violent phase transformation from NiHCF to Zn2Fe(CN)6 in 3 M Zn(OTf)2‐H2O electrolyte, indicating that 0.5 M Zn(OTf)2‐EA electrolyte can inhibit the negative phase transformation aging process of NiHCF and improve the electrochemical performance effectively. Impressively, the Zn/NiHCF battery with 0.5 M Zn(OTf)2‐EA as electrolyte exhibits a really high capacity retention rate of 94.2 % after 500 cycles at 150 mA g−1.
Synergistic Effects on the Mercury Sorption Behaviors Using Hybrid Cellulose Fiber/Chitosan Foam
Authors: Allouche Fella‐Naouel 
Published: September 2022

AbstractThe aim of this study is to explore the use of a possible combination of both cellulose fiber and chitosan as natural renewable polymer to introduce a circular economy concept. In this work, cellulose fibers were incorporated into chitosan to prepare hybrid foam (1/5 w/w). The conditioned composite material was obtained by co‐dissolution in acetic acid using the freeze‐drying method. Column experiments were performed on the prepared foam to study the kinetic of mercury sorption to evaluate their feasibility and real applications in different industrial sectors. Experimental data show that the maximum adsorption capacity of mercury by hybrid cellulose fiber/chitosan foam is 400 mg g−1, pH 4.0 at 20 °C. Scanning electron microscopy (SEM), energy‐dispersive X‐ray spectroscopy EDX and specific surface area with BET analysis were used to provide a qualitative estimation of the fabricated composite foam. To elucidate the chemical modification of the material, FT‐IR analysis was performed. The resulting composite foam still demonstrates excellent adsorption performance after regeneration.
Recent Advances on the Role of Nitrogen‐Based Heterocyclic Scaffolds in Targeting HIV through Reverse Transcriptase Inhibition
Authors: Kumar Ankur , Wahan Simranpreet K. , Virendra Sharma Arvind , Chawla Pooja A. 
Published: September 2022

AbstractAcquired immune deficiency syndrome (AIDS) caused by human immunodeficiency virus continues to scavenge lives of millions around the world. Reverse transcriptase (RT) also known as the RNA‐directed DNA polymerase enzyme is responsible for converting RNA into viral DNA through process known as reverse transcription. Investigations on the pathogenic aspects of the RT enzyme, its associated elements such as gag (group‐specific antigen gene), pol (polymerase gene), and env (environmental gene) (envelope gene) reveals its contribution towards emergence of resistance to all various anti‐HIV drugs. Therefore, research into the control and blockage of the RT pathway has been a prominent focus in the quest for novel targets for HIV treatment. A slew of heterocyclics has been claimed to play a significant part in the fight against doomy HIV, saving the lives of millions of people throughout the world and providing hope for HIV treatment. Due to their improved potency and selectivity, as well as the fact that they have fewer off‐target effects against the several targets implicated in RT inhibition, heterocyclics are becoming more and more useful. The RT inhibition pathway, the function of numerous heterocyclic scaffolds, and their ability to inhibit the RT enzyme pathway have all been the main topics of this paper. Recent advances in RT inhibitors in the last eight years (2014–2022) including mechanisms of action, preclinical and clinical investigations, structural activity relationships, and docking studies, to investigate mechanistic studies that would eventually aid in the design and development of powerful RT inhibitors have also discussed.
Effect of Nb(V) doping on the Structure and Oxygen Chemisorption on Nanocrystalline TiO2
Authors: Kuranov Dmitry , Platonov Vadim , Khmelevsky Nikolay , Bozhev Ivan , Maksimov Sergey , Rumyantseva Marina , Krivetskiy Valeriy 
Published: September 2022

AbstractThis work is devoted to the study of the effect of niobium doping on the structural characteristics and chemisorption of oxygen on the TiO2 surface. Pure and Nb doped TiO2 was obtained by flame spray pyrolysis and characterized using SEM, TEM, XRD, low‐temperature nitrogen adsorption XRF, XPS, TPR‐H2 methods. The introduction of niobium stabilizes the anatase phase, increases the specific surface area of TiO2 and the concentration of chemisorbed oxygen. By in situ conductivity measurements depending on the oxygen partial pressure, it is shown that an increase in the Nb concentration leads to the growth of the fraction of chemisorbed oxygen with a lower effective charge.
Waste Polystyrene‐derived Sulfonated Fluorescent Carbon Nanoparticles for Cation Sensing
Authors: Teo Jerald Y. Q. , Zheng Xin Ting , Seng Debbie Hwee Leng , Hui Hui Kim , Chee Pei Lin , Su Xiaodi , Loh Xian Jun , Lim Jason Y. C. 
Published: September 2022

AbstractPolystyrene, one of the most widely‐produced plastics worldwide, is non‐biodegradable and has unsustainable life‐cycles with only a small fraction recycled presently. Hence, there is considerable effort underway to explore new methods to give post‐consumer polystyrene waste a new lease‐of‐life as functional materials. In this study, we report the synthesis of the first polyanionic fluorescent carbon nanoparticles from sulfonated waste polystyrene food containers via an environmentally‐benign route in water. By virtue of their sulfonate groups, these biocompatible and fluorescent nanoparticles show a number of distinct behaviours in the presence of different main group and transition metal cations. Al3+ brings about both fluorescence enhancement and nanoparticle precipitation, whilst fluorescence quenching was observed for paramagnetic and toxic transition metal cations, with Cu2+ eliciting the most sensitive fluorescence response (LoD=26 μM). These fluorescence intensity perturbations are likely a consequence of direct metal cation coordination to the exposed sulfonate groups on the nanoparticles. Our findings suggest the potential of using post‐synthetically modified waste plastics to produce a family of luminescent carbon materials for environmental sensing of these hazardous cations.
Size‐Controllable Synthesis of ZIF‐8 and Derived Nitrogen‐Rich Porous Carbon for CO2 and VOCs Adsorption
Authors: Qiu Jingting , Xu Xiang , Liu Baogen , Guo Yang , Wang Huijun , Yu Lingyun , Jiang Yuwei , Huang Changsheng , Fan Binfeng , Zeng Zheng , Li Liqing 
Published: September 2022

AbstractIt's acknowledged that surface chemical and pore structure of adsorbent are main parameters to determine adsorption results. Herein, we prepared zeolitic imidazolate frameworks‐8 (ZIF‐8) with different average sizes (50, 120, and 2200 nm) and demonstrated their specific surface area and pore volume decreased with increasing particle size. ZIF‐8 (ZN) exhibits a large specific surface area (1626.4 m2 g−1) and total pore volume (1.088 mL g−1), but it has been shown to lack the non‐specific adsorption capacity for the adsorbate. Carbonization at 800 °C is proved to be an effective method to expose massive surface nitrogen‐containing functional groups and adjust the aperture to an appropriate pore size range for derived porous carbon of ZIF‐8 (ZCN). High nitrogen content (18.7 at. %) greatly improves the affinity for CO2 and Volatile Organic Compounds (VOCs), as explained by the density functional theory (DFT) calculation results. Meanwhile, particle size influences the pore‐forming results after carbonization directly. Among them, ZC50 generates a certain amount of narrow micropore in range of 0.7–1.0 nm, located in the optimal pore size range of CO2 adsorption calculated by Grand canonical Monte Carlo (GCMC) simulation, thus possessing the largest CO2 adsorption capacity (4.03 mmol g−1 at 25 °C). Besides, ZC120 exhibits more superior mesopore structure that could strengthen multilayer adsorption for VOCs.
Less Is More: Hollow‐Truss Microlattice Metamaterials with Dual Sound Dissipation Mechanisms and Enhanced Broadband Sound Absorption
Authors: Li Xinwei , Yu Xiang , Zhai Wei 
Published: September 2022

AbstractBeing a lightweight material with high design freedoms, there are increasing research interests in microlattice metamaterials as sound absorbers. However, thus far, microlattices are limited to one sound dissipation mechanism, and this inhibits their broadband absorption capabilities. Herein, as opposed to improving performances via the addition of features, a dissipation mechanism is subtractively introduced by hollowing out the struts of the microlattice. Then, a class of hollow‐truss metamaterial (HTM) that is capable of harnessing dual concurrent dissipation mechanisms from its complex truss interconnectivity and its hollow interior is presented. Experimental sound absorption measurements reveal superior and/or customizable absorption properties in the HTMs as compared to their constitutive solid‐trusses. An optimal HTM displays a high average broadband coefficient of 0.72 at a low thickness of 24 mm. Numerically derived, a dissipation theorem based on the superimposed acoustic impedance of the critically coupled resistance and reactance of the outer‐solid and inner‐hollow phases, across different frequency bands, is proposed in the HTM. Complementary mechanical property studies also reveal improved compressive toughness in the HTMs. This work demonstrates the potential of hollow‐trusses, where they gain the dissipation mechanism through the subtraction of the material and display excellent acoustic properties.
Anticipatory Recurrent Monitoring with Uncertainty and Assumptions
Authors: Kallwies Hannes , Leucker Martin , Sánchez César , Scheffel Torben 
Published: September 2022

AbstractRuntime Verification is a lightweight verification approach that aims at checking that a run of a system under observation adheres to a formal specification. A classical approach is to synthesize a monitor from an LTL property. Usually, such a monitor receives the trace of the system under observation incrementally and checks the property with respect to the first position of any trace that extends the received prefix. This comes with the disadvantage that once the monitor detects a violation or satisfaction of the verdict it cannot recover and the erroneous position in the trace is not explicitly disclosed. An alternative monitoring problem, proposed for example for Past LTL evaluation, is to evaluate the LTL property repeatedly at each position in the received trace, which enables recovering and gives more information when the property is breached. In this paper we study this concept of recurrent monitoring in detail, particularly we investigate how the notion of anticipation (yielding future verdicts when they are inevitable) can be extended to recurrent monitoring. Furthermore, we show how two fundamental approaches in Runtime Verification can be applied to recurrent monitoring, namely Uncertainty—which deals with the handling of inaccurate or unavailable information in the input trace—and Assumptions, i.e. the inclusion of additional knowledge about system invariants in the monitoring process.
Eccentrically widened bone tunnels after all-inside anterior cruciate ligament reconstruction: a computed tomography and three-dimensional model-based analysis
Authors: Liu Di , Cai Zi-Jun , Lu Wen-Hao , Pan Lin-Yuan , Yang Yun-Tao , Li Yu-Sheng , Xiao Wen-Feng 
Published: September 2022

Abstract
Purpose
To evaluate the extent of tunnel widening after anterior cruciate ligament reconstruction (ACLR) using the all-inside technique and to establish its correlation with patient-reported clinical outcomes and femoral graft bending angle (GBA).

Methods
Tunnel widening was evaluated using computed tomography (CT)-based three-dimensional (3D) models, and the femoral GBA was directly measured on CT images using the Picture Archiving and Communication System (PACS) software. Clinical follow-up was routine procedure, and patient-reported clinical outcomes mainly included International Knee Documentation Committee (IKDC), Lysholm, and Knee Injury and Osteoarthritis Outcome Scores (KOOS) scores, and subjective knee stability assessment.

Results
Fifty-two patients received standard all-inside ACLR, with a median follow-up of 6 months. Reconstructed anterior cruciate ligaments (ACLs) were scanned during the first 3 days and 6 months after surgery. On both the femoral and tibial sides, bone tunnels were most significantly enlarged at the articular aperture segment; the femoral tunnel was 9.2 ± 1.3 mm postoperatively and was significantly enlarged by 32% to a mean tunnel diameter of 12.1 ± 2.0 mm at 6 months after surgery. Moreover, the extent of tunnel enlargement gradually decreased as the measured levels approached those of the bone cortex. The femoral tunnel center was shifted into the anterior and distal direction, and the tibial tunnel center was shifted into the posterior and lateral direction. Additionally, the mean femoral GBA was 105.9° ± 8.1° at the 6-month follow-up. Tunnel enlargement and GBA were not significantly correlated with patient-reported outcomes.

Conclusions
Femoral and tibial tunnels were significantly greater and eccentrically shifted at the 6-month follow-up after all-side ACLR. However, the extent of tunnel widening does not markedly affect the short-term clinical outcomes. Meanwhile, the femoral GBA was not significantly correlated with femoral tunnel widening or patient-reported outcomes. Although the tunnel widening following all-inside ACLR was not associated with clinical outcomes, it potentially caused difficulties in revision ACLR.

Level of evidence
Level IV.
Determination of hair cortisol in horses: comparison of immunoassay vs LC-HRMS/MS
Authors: Saluti Giorgio , Ricci Matteo , Castellani Federica , Colagrande Maria Novella , Di Bari Gabriella , Vulpiani Michele Podaliri , Cerasoli Francesco , Savini Giovanni , Scortichini Giampiero , D’Alterio Nicola 
Published: September 2022

AbstractThe measure of hair cortisol concentration (HCC) is becoming an emerging approach to monitor mid-/long-term stress in animals, so it is more and more important to develop accurate and reliable methods. In the light of this, the aim of the present study was to compare mane HCCs of 47 horses with different managements, by means of an immunoassay (ELISA) and liquid chromatography coupled to hybrid high-resolution mass spectrometry (LC-HRMS/MS). After the washing step, the ground hair was extracted with methanol. The extract was evaporated and redissolved in two different aqueous solutions, depending on the detection technique. The methods were validated according to EMA guideline for bioanalytical method validation, in the range 2–50 pg mg−1 (ELISA) and 1–100 pg mg−1 (LC-HRMS/MS). Satisfactory quantitative performances were obtained for both of the approaches, but this latter demonstrated better precision. The detected concentrations in real samples were encompassing the range 1.3–8.8 pg mg−1 and 2.0–17.9 pg mg−1 by means of LC-HRMS/MS and ELISA, respectively. Overall, HCCs measured with ELISA technique were 1.6 times higher. The overestimation of immunoassay results might be caused by cross-reactivity phenomena of laboratory reagents and other structurally similar hormones present in the mane.
Graphical abstract
Refined Parameterizations for Computing Colored Cuts in Edge-Colored Graphs
Authors: Morawietz Nils , Grüttemeier Niels , Komusiewicz Christian , Sommer Frank 
Published: September 2022

AbstractIn the NP-hard Colored (s,t)-Cut problem, the input is a graph G = (V,E) together with an edge-coloring ℓ : E → C, two vertices s and t, and a number k. The question is whether there is a set $S\subseteq C$
S
⊆
C
of at most k colors such that deleting every edge with a color from S destroys all paths between s and t in G. We continue the study of the parameterized complexity of Colored (s,t)-Cut. First, we consider parameters related to the structure of G. For example, we study parameterization by the number ξi of edge deletions that are needed to transform G into a graph with maximum degree i. We show that Colored (s,t)-Cut is W[2]-hard when parameterized by ξ3, but fixed-parameter tractable when parameterized by ξ2. Second, we consider parameters related to the coloring ℓ. We show fixed-parameter tractability for three parameters that are potentially smaller than the total number of colors |C| and provide a linear-size problem kernel for a parameter related to the number of edges with rare edge colors.
Combined [68 Ga]Ga-PSMA-11 and low-dose 2-[18F]FDG PET/CT using a long-axial field of view scanner for patients referred for [177Lu]-PSMA-radioligand therapy
Authors: Alberts Ian , Schepers Robin , Zeimpekis Konstantinos , Sari Hasan , Rominger Axel , Afshar-Oromieh Ali 
Published: September 2022

Abstract
Purpose
Performing 2-[18F]FDG PET/CT in addition to a PSMA-ligand PET/CT can assist in the detection of lesions with low PSMA expression and may help in prognostication and identification of patients who likely benefit from PSMA-radioligand therapy (PSMA-RLT). However, the cost and time needed for a separate PET/CT examination might hinder its routine implementation. In this communication, we present our initial experiences with additional low-dose 2-[18F]FDG PET/CT as part of a dual-tracer and same-day imaging protocol which exploits the higher sensitivity exhibited by long-axial field-of-view (LAFOV) and total-body PET/CT systems and demonstrates its feasibility.

Methods
Fourteen patients referred for evaluation for PSMA-RLT received [68 Ga]Ga-PSMA-11 PET/CT at 1 h p.i. with a standard activity of 150 MBq and an additional low-dose 2-[18F]FDG PET/CT with 40 MBq 1 h thereafter using a long-axial field-of-view PET/CT system in a single sitting and as per institutional protocol. Scans were scrutinized by two experienced nuclear medicine physicians for mismatch findings.

Results
The combined protocol identified additional lesions with low or absent PSMA-expression but high FDG-avidity in 1/14 (7%) patients. The protocol was easily implemented and well tolerated by all patients.

Conclusion
Additional low-dose 2-[18F]FDG-PET/CT is feasible as part of a same-day imaging protocol and can help reveal lesions of low PSMA avidity as part of therapy assessment for [177Lu]-PSMA radioligand therapy and demonstrates higher sensitivity compared to [68 Ga]Ga-PSMA-11 PET/CT alone in some patients.