bluuebunny/crossref_metadata_2025_split huggingface dataset:
Early and Midterm results of Frozen Elephant Trunk Operation with Evita Open Stent-Graft in Patients with Marfan Syndrome: Results of a Multicentre Study
Authors: Widenka Kazimierz Jan , Kosiorowska Monika , Jakob Heinz , Pacini Davide , Hemmer Wolfgang , Grabenwoeger Martin , Sioris Thanos , Moritz Anton , Tsagakis Konstantinos 
Published: April 2022

Abstract
Background: Endovascular treatment of patients with Marfan syndrome (MFS) is not recommended. Hybrid procedures such as frozen elephant trunk (FET), which combines stent-graft deployment and an integrated non-stented fabric graft for proximal grafting and suturing have not been previously evaluated. The aim of this study was to assess the safety and feasibility of FET operation in patients with MFS. Methods: Between January 2005 and January 2017 out of 1049 patients 1020 who underwent the FET procedure were enrolled in the International E-vita Open Registry (IEOR). Included were patients, who met Ghent criteria for MFS. Early and midterm results were retrospectively analyzed. Postoperative and follow-up computed tomography angiography scans were analyzed. Results: We analyzed 37 patients [mean age 38±11 years, 65% men]. Acute or chronic aortic dissection was present in 35 (95%) patients (14 and 21 patients respectively). Two (5%) patients had an aneurysm without dissection. Malperfusion syndrome was present in 4 patients. Twenty-nine (78%) patients had previous aortic surgical interventions. The 30-day and in-hospital mortality was 8 and 14% respectively. False lumen exclusion was presented in 73% in stented segment. The overall 5-year survival was 71% and freedom from reintervention downstream was 58% at 5 years. Of the nine patients who required reintervention for distal aortic disease one patient died.Conclusions: FET operation for patients with MFS can be performed with acceptable mortality and morbidity. In long-term follow up no reinterventions on the aortic arch were required. FET allows for easier second stage operations providing platform for surgical and endovascular reinterventions.
Stillbirths in Cameroon: An analysis of the 1998–2011 Demographic and Health Surveys
Authors: Amani Adidja , Nansseu Jobert Richie , Ndeffo Guy Ferdinand , Lekeumo Fabrice Zobel Cheuyem , Libite Paul Roger , Ateba Athanase A. , Bama Solange Ngo , Baye Martina Lukong , Enow Robinson Mbu 
Published: April 2022

Abstract
Background
Many countries including Cameroon have been finding it challenging to have accurate estimates of stillbirths, as there are no figures that have previously been routinely reported. The objective of this analysis was to estimate stillbirth rates and identify risk factors for stillbirth in Cameroon, using successive Demographic and Health Survey data.
Methods
We conducted a cross-sectional analysis of data collected during the Demographic and Health Surveys carried out in 1998, 2004 and 2011. Stillbirth was defined as a late fetal death occurring at or beyond 6 months of gestation. Stillbirth rates were estimated over the total number of births.
Results
The crude stillbirth rate was 21,4‰ in 2004 and 24‰ in 2011 with respective standard errors of 1.8 and 1.3. The stillbirth rate tended to increase with the age of the mother (p < 0.001). The reduction of stillbirth rate has been extremely slow between 1998 and 2011, with an annual reduction rate of 1.5%. The study observed that residing in rural areas, low socio-economic status, and low level of education were risk factors associated with stillbirths.
Conclusion
The stillbirth rate remains very high in Cameroon, with a slow reduction rate over the last 20 years. Although some effort has been made, there is still a long way forward to bend the curve for stillbirths in Cameroon; supplementary strategies need to be designed and implemented, especially among rural women, the poor and less educated.
Effects of the inclusion of Ce and Ni species on K10-clay modified with Ti and their use as catalysts in the liquid-phase esterification systems
Authors: Rangel-Rivera P. , Rangel-Porras G. , Quiroga-Almaguer A. , Ramírez-Hernández A. , Bachiller-Baeza B. , Pfeiffer-Perea H. 
Published: April 2022

Abstract
The modification of clays including montmorillonites, is a common procedure that gives to the resulting material additional properties compared to the pristine clay. One of these procedures is the modification of the surface/matrix of the clay with inorganic species, to enhance their catalytic and adsorptive properties. In the present study, montmorillonite-clay K10 modified with particles of Ti species and Ti additionally modified with Ce and Ni species, were characterized by X-ray diffraction of powders (XRD), Fourier transform infrared spectroscopy (FTIR), physisorption of N2 at 77K (BET and BJH), and thermal analysis (TA). Finally, clays were tested in the esterification of acetic acid and penta-1-ol in the liquid-phase. The effect of the inclusion of Ti species and the modified of Ti with Ce and Ni species was discussed in terms of the transformation of the nanostructure of the modified clay, and their contribution to the catalytic esterification performance.
Impact of COVID-19 on the incidence of CT-diagnosed appendicitis and its complications in the United Kingdom and Sweden
Authors: Torkzad Michael R. , Thorisson Arnar , Chabok Abbas , Nikberg Maziar , Andersson Roland E , Labruto Fausto 
Published: April 2022

Abstract
Aim
To compare the number of appendicitis cases and its complications, during the first months of the COVID-19 pandemic in Sweden and the United Kingdom and the corresponding time period in 2019.
Method
Reports of emergency abdominopelvic CT performed at 56 Swedish hospitals and 38 British hospitals between April and July 2020 and a corresponding control cohort from 2019 were reviewed. Two radiologists and two surgeons blinded to the date of cohorts analysed all reports for diagnosis of appendicitis, perforation, and abscess. A random selection of cases was chosen for the measurement of inter-rater agreement.
Result
Both in Sweden (6111) and the United Kingdom (5591) fewer abdominopelvic CT scans were done in 2020 compared to 2019 (6433 and 7223, respectively); p < 0.001. In UK, the number of appendicitis was 36% lower in April-June 2020 compared to 2019 but not in Sweden. Among the appendicitis cases, there was a higher number of perforations and abscesses in 2020, in Sweden. In the United Kingdom, the number of perforations and abscesses were initially lower (April-June 2020) but increased in July 2020. There was a substantial inter-rater agreement for the diagnosis of perforations and abscess formations (K = 0.64 and 0.77).
Conclusion
In Sweden the number of appendicitis was not different between 2019 and 2020, however, there was an increase of complications. In the United Kingdom, there was a significant decrease of cases in 2020. The prevalence of complications was lower initially but increased in July. These findings suggest variability in delay in diagnosis of appendicitis depending on the country and time frame studied.
Vertebroplasty combined with facet joint block vs. vertebroplasty alone in relieving acute pain of osteoporotic vertebral compression fracture: a randomized controlled clinical trial
Authors: Dang Sha-Jie , Wei Wen-Bo , Wei Ling , Xu Jin 
Published: April 2022

Abstract
Objective: To compare the efficacy of percutaneous vertebroplasty (PVP) combined with facet joint block (FB) and vertebroplasty alone on osteoporotic vertebral compression fractures (OVCFs). Methods: A prospective, randomized controlled study was conducted. 198 patients with OVCFs were randomly divided into two groups in the study: Group P (PVP, n=97), Group PF (PVP combined with FB, n=101). The Visual analogue scale (VAS) and Oswestry disability index (ODI) were measured during pre-operation, 1 day, 1, 3, 6 and 12 months after the operation, respectively. The hospitalization time, operation time, complications, recurrence and the number of patients who applied Cox-2 inhibitors within 3 days after operation were compared in the two groups. Results: The VAS and ODI scores at each observation point of the post-operation significantly decreased than the pre-operation in both groups (P < 0.05). The VAS and ODI scores in Group PF significantly lower than that in Group P 1 day and 1 month after the operation (P < 0.05). The number of patients who applied Cox-2 inhibitors within 3 days after operation in group PF significantly lower than that in Group P (P <0.001). There was no significant difference in hospitalization time, operation time, complication rate, VAS and ODI scores at the pre-operation (P > 0.05). Conclusion: Both PVP combined with FB and PVP alone are effective treatment methods for OVCFs. PVP combined with FB showed better back pain relief than PVP alone in the short term after the operation for OVCFs.
Reliability assessment of sodium ( 23 Na) MRI at 7.0 T in healthy human calf muscle and preliminary results on tissue sodium concentrations in subjects with Addison’s disease
Authors: TRATTNIG Siegfried , ZARIC Olgica , BEIGLBÖCK Hannes , JANACOVA Veronika , SZOMOLANIY Pavol , WOLF Peter , KREBS Michael , KRŠŠÁK Martin , JURAS Vladimir 
Published: April 2022

Abstract
Objectives: To determine the relaxation times of the sodium nucleus, and to investigate the reliability of quantitative, in vivo TSC measurements using sodium magnetic resonance imaging (23Na-MRI) in human skeletal muscle and explore the discriminatory value of the method by comparing TSCs between healthy subjects and patients with Addison’s disease. Materials and Methods: In this prospective study, ten healthy subjects and five patients with Addison’s disease were involved. 23Na-MRI data sets were acquired using a density-adapted, three-dimensional radial projection reconstruction pulse sequence (DA-3DPR) with a modification for the relaxation times measurements. Differences in TSC between muscle groups and between healthy participants were analyzed using a nonparametric Friedman ANOVA test. An interclass correlation coefficient (ICC) was used as the reliability index.Wilcoxon rank sum test was used for evaluation of differences in TSC between study participants. Results: The mean T1 in the gastrocnemius medialis (GM), the tibialis anterior (TA), and the soleus (S) was 25.9±2.0ms, 27.6±2.0ms, and 28.2±2.0ms, respectively. T2*mono values were GM, 12.0±0.9ms; TA, 12.8±0.7ms; and S, 12.9±2.0ms. In healthy volunteers, TSC values in the GM were 20.0±1.0mmol/L, 14.1±0.9mmol/L in TA, and 12.8±0.8mmol/L in S, and were significantly different (p=0.0005). The ICCs for GM, TA and S were 0.784, 0.818, 0.807, respectively. In patients with Addison’s disease, TSC in GC, TA, and S were 10.2±1.0mmol/L, 8.4±0.6mmol/L, and 7.2±0.1mmol/L, respectively.Conclusions: TSC quantification in a healthy subject’s calf at 7.0 T is reliable; the technique is able to distinguish sodium level differences between muscles and between healthy subjects and Addison’s disease patients.
How blogs support the translation of research into practice in the field of dementia palliative care: a survey of facilitators and barriers
Authors: Rukundo Aphie , Fox Siobhan , Guerin Suzanne , Kernohan George , Drennan Jonathan , O'Connor Niamh , Timmons Suzanne 
Published: April 2022

Abstract
Background: Blogging can help to maximise the impact of one’s work in academia and beyond by making research findings accessible for multiple knowledge users, such as healthcare professionals and the public, as well as other researchers. As part of the knowledge exchange and dissemination activities of the Model for Dementia Palliative Care Project, this study explored stakeholders’ views of blogs as a means to translate research findings.Methods: A web-based survey was developed, piloted, and revised. It was distributed electronically via key dementia and palliative care organisations websites, newsletters, social media platforms, and within the staff mailing lists of five Universities in Ireland. Data were analysed using descriptive statistics and content analysis.Results: Complete responses were received from 128 participants. The majority of respondents were healthcare researchers (n=53), followed by healthcare providers (n=46). The preferred methods of reviewing research findings were scientific papers, websites and news articles. Respondents read healthcare blogs “sometimes” (39.1%), with <19% reading them “often” or “very often”. Receiving an email notification might increase the likelihood of reading a new blog post for 83% of respondents. Barriers to engaging with blogs included lack of time, preference for other media, lack of awareness regarding available blogs, and concerns about the credibility and source of information. An appropriate length and the author of the blog were key features that encouraged engagement with a blog.Conclusions: Despite respondents choosing a scientific paper as their preferred method to consume research findings, many indicated an openness to reading blogs on their area of interest. Creating concise, relevant, and credible blogs, and suitably promoting them, could increase the impact and reach of healthcare research, such as in the emerging field of dementia palliative care, and thus promote translation of research findings into practice.
Identification of necroptosis-Related subtypes,the development of a prognosis model, and characterization of tumor microenvironment infiltration in Hepatocellular carcinoma
Authors: Zhang Guozhi , Jia Xiangen , Qin Yuning 
Published: April 2022

Abstract
Purpose:Necrotizing apoptosis, known as a novel programming necrotic cell death, has been proved to be related to cancer progression. The precise functions of necrosis-related genes (NRGs) in the tumor microenvironment (TME) are, nevertheless, unknown. Our aim is to explore the various roles of NRGs in the development of liver cancer.Methods:In our study, the expression profiles and corresponding clinical characteristics of Hepatocellular carcinoma(HCC) samples were obtained from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases. There were two molecular subtypes identified and NRGs changes were investigated to appear association with clinicopathological features, prognosis and TME cell infiltration. The NRGs score was then created for estimating overall survival (OS), and its prediction power for HCC patients was tested. Finally, a high-precision nomogram is constructed to improve the clinical applicability of NRGs score. Results:We found that low NRGs_score was linked to higher immunological and stromal score and overall survival rate. In addition, NRGs_score chemotherapy drug sensitivity was significantly correlated. Our systematic and comprehensive analysis of NRGs confirmed their prospective function in the microenvironment of the tumor immune matrix and prognosis These findings may help us better understand NRGs in hepatocellular carcinoma, providing clues for assessing prognosis and developing more effective immunotherapy strategies.Conclusion:Our comprehensive analysis of NRGs in HCC demonstrated their potential roles in the tumor-immune-stromal microenvironment, clinicopathological features, and prognosis. These findings improve our understanding of NRGs in HCC and pave a new path for the assessment of prognosis and the development of more effective immunotherapy strategies.
Clonidine ameliorates cerebral ischemia-reperfusion injury by modulating the GluN3 subunits of NMDA receptor
Authors: He Zhi , Chen Jing , Zhang Juan , Yang Dan Dan , Li Cheng Zi , Zhao Bo , Chen Yue 
Published: April 2022

Abstract
Clonidine is a classical alpha-2 adrenergic receptor (α2-AR) agonist that has been used clinically in the treatment of hypertension. This study aimed to investigate the protective effects of clonidine on the cerebral ischemia–reperfusion (I/R) injury and elaborate the underlying mechanisms. Adult male SD rats were divided into sham or cerebral I/R operation. Saline, clonidine and yohimbine(an α2-AR antagonist) were intraperitoneally administered each day for one week before surgery. Neurological deficit was evaluated just before decapitation. TTC staining was applied for correlation of cerebral infarction volume. HE staining was performed to observe the neuron morphology. Immunohistochemical staining was performed to detect the localization and expression of GluN3 proteins. Western blot analysis also was used to detect the expression levels of GluN3 proteins. Our data showed that clonidine ameliorated neurological deficit and reduced the cerebral infarction volume of the rats with cerebral I/R. It is worth noting that treatment with clonidine up-regulated the protein expression of GluN3 in the rats with the cerebral I/R, especially in the cell membrane. Moreover, clonidine also up-regulated the transposition from cytoplasm to cell membrane of GluN3 after cerebral I/R. In addition, yohimbine abolished the neuroprotective effects of clonidine. The results indicated that clonidine played a protective role in cerebral I/R injury via different mechanisms that could be mediated, in part, through modulation of the protein expression of GluN3 subunits of N-methyl-D-aspartate (NMDA) receptor.
Diastolic blood pressure increases subsequent risk of breast cancer in postmenopausal women: results from the Health Examinees-Gem Study
Authors: Kang Daehee , Torre Katherine De la , Shin Woo-Kyoung , Huang Dan , Lee Hwi-Won , Shin Aesun , Lee Jong-koo , Lee Hae-Young 
Published: April 2022

Abstract
Epidemiological evidence suggests that hypertension is associated with breast cancer risk. However, the results of previous studies disregard blood pressure components in the healthy population. We aim to examine the relationship between systolic and diastolic blood pressure and breast cancer risk in a Korean population-based prospective cohort. A total of 73,031 women from the Health Examinees Gem Study were followed from baseline (2004 to 2013) through 2018. Systolic and diastolic blood pressure were measured by trainee physicians at baseline recruitment and then categorized based on the international guidelines for clinical hypertension. Associations between systolic and diastolic blood pressure with breast cancer overall and stratified by premenopausal and postmenopausal status were evaluated using adjusted multivariable Cox proportional hazard regression. A total of 858 breast cancer cases were recorded for a median follow-up period of 9 years. Compared with the normal diastolic blood pressure category (< 85mm Hg), the increased risk categories were positively associated with breast cancer risk in postmenopausal women (≥ 85mm Hg, HR: 1.73 95%IC 1.28–2.33) with a dose-dependent effect, but not in premenopausal women (≥ 85mm Hg, HR: 0.87 IC95% 0.56–1.35). Similar results were found when excluding all cases of self-reported hypertension. Results for systolic blood pressure did not show a significant association with breast cancer risk. The association of DBP with breast cancer suggests DBP is an important factor in cancer prevention, especially for women after menopause. Our study provides a first detailed approach to understanding the importance of diastolic blood pressure for breast cancer prevention and warrants further investigation.
Adaptive Reservoir Management by Reforming the Zone-based Hedging Rules against Multi-year Droughts
Authors: Kim Gi Joo , Kim Young-Oh , Seo Seung Beom 
Published: April 2022

Abstract
In this study, the zone-based hedging rule, which is the main operating policy adopted from multipurpose reservoirs in Korea is adjusted to reflect the multi-year droughts caused by climate change. Annual synthetic inflow series with different magnitudes of long memory were generated using the autoregressive fractional integrated moving average (ARFIMA) model. The generated inflow series were then disaggregated into 10-day series and utilized as input variables to derive the alternative hedging rules. The alternative hedging rules from this study were used in adaptive reservoir management by newly updated information. Finally, the performance of the suggested policy is measured in terms of frequency and magnitude under the historical inflow series. As a result, adaptive reservoir management demonstrated improvements in the following terms of the frequency of critical failures (water deficit ratio greater than 30%): 6.14% of the simulation period in the status quo (SQ) policy, and 2.99% in the adaptive management. However, the overall reliability of the reservoir during the simulation horizon was better when operated with the SQ policy (41.19%) than the results from adaptive management (26.42%). Because this result is in a good agreement with the original objective of the hedging rules, the adaptive policy suggested in this study holds promise and may be utilized in further reservoir management under drought conditions.
Depicting developing trend and core knowledge of Pigmented Villonodular Synovitis: a bibliometric and visualized analysis
Authors: He Jinshen , Chen Qi , Li Jinfei , Chen Shuyi 
Published: April 2022

Abstract
Background Pigmented Villonodular Synovitis（PVNS）is a subtype of Tenosynovial Giant Cell Tumor that can broadly affect the soft tissue inner layer of the joints and tendons. It has a high rate of invasiveness and recurrence, which means it has become a crucial issue. This study provides information on the present status, evolutionary path, worldwide trends, frontier research hotspots, and future research developmental trends in this field. Methods Publications from 1971 to 2021 were retrieved from the Web of Science database and analyzed using a bibliometric methodology. VOSviewer software was utilized for analysis.Results There is an increasing trend of relative research interests and the number of publications per year globally. The research institution with the highest documents and citations was Harvard University. The United States showed its dominant position in publication outputs, followed by China and Germany. Clin Orthop Relat Res and Skeletal Radiol have published the most papers in this field. The keywords can be divided into eight clusters: ‘mortality’, ‘surgical management’, ‘rehabilitation’, ‘osteoporosis’ and ‘epidemiology’. Conclusions The publications about PVNS research would be remaining at a high level in the future based on the current global trends. The key focus of PVNS has been synovectomy, joint replacement, radiation therapy, and targeted therapy. Most patients can be controlled through simple surgery, and more research needs to be conducted for patients who need comprehensive treatment.
Development and optimization of a rat Purkinje neuron culture to study paraneoplastic cerebellar degeneration
Authors: Uggerud Ida Margrethe , Krakenes Torbjorn , Hirai Hirokazu , Vedeler Christian Alexander , Schubert Manja 
Published: April 2022

Abstract
Background: Elucidation of the mechanisms involved in neurodegenerative disease has been hampered by the lack of robust cellular models that replicate in vivo features. Methods: We developed a refined protocol for generation of age-dependent, well-developed, and synaptically active rat Purkinje neurons in a multilayer cell network culture that can be used to study neurodegenerative diseases such as paraneoplastic cerebellar degeneration (PCD). Result: Independent of the age of the tissue from which the culture was driven, the properties of the generated rat Purkinje neuron culture are complex and robust, allowing great experimental flexibility. Using our model, we found that the application of Yo antibodies, which are associated with PCD, alters the structure of the dendritic arbour of cultured Purkinje neurons within 48h. The numbers of dendrites per branch-order, the branch-order in itself, and the dendritic length were reduced by treatment with anti-Yo. Conclusion: The here presented in vitro model is flexible and can be used to investigate disease mechanisms that disturb Purkinje neuron function and communication in a multilayer network. It proved that anti-Yo has a functional role in the pathogenesis of PCD.