bluuebunny/crossref_metadata_2025_split huggingface dataset:
Molecular Dynamic study on the aggregation process of biologic surfactant with oleic matter
Authors: Braga Bibiana 
Published: August 2022

Abstract

The present work aims to study nominally known oleic systems – oleic acid, saponified oleic acid and biodiesel – in the presence of a biological surfactant, sodium cholate. For a better characterization of this system, dynamic light scattering and electrical impedance spectroscopy techniques were used. Through the first technique, it was possible to differentiate the systems by their sizes (hydrodynamic rays) and it was observed that the stereo effect caused by the interaction of different structures of the oleic material and the surfactant directly impacts the dimension of the formed particles. The Electrical Impedance experiment did not show differences in the electrical behavior of these particles, which shows that the electrostatic interaction between these particles does not vary significantly, regardless of the oleic material used.
Exploring nursing students' experiences on distance education: a qualitative content analysis
Authors: TANK Dilek YILDIRIM , ÇAĞLAR Serpil SUBAŞI , ERGEN Büşra 
Published: August 2022

Abstract
Background
The effects of the use of distance education methods, which entered our lives rapidly with the pandemic, in nursing education should be discussed.
Aim
To determine the experiences of nursing students about distance education.
Methods
Data were collected using a SWOT analysis interview form developed by the researchers. Study was carried out at a national university in Zonguldak, Turkey between February 2020 and January 2021. The sample of the study comprised 204 students in the nursing department.
Results
Students reported their positive and negative thoughts on issues such as working environment, technological adaptation, economic conditions, lack of clinical education, psychological and health problems.
Conclusion
In terms of nursing education, the distance education system should be researched and developed in depth.
Multi-objective double row layout problem with safety distance and geometrical constraints consideration
Authors: Rifai Achmad Pratama , Mara Setyo Tri Windras , Norcahyo Rachmadi 
Published: August 2022

Abstract
This study discusses the extension of the double row layout problem (DRLP) with safety distance and geometrical constraints for unequal dimension of rows. A multi-objective mathematical formulation is proposed with aims to minimize the total material handling cost and penalty for safety violation. As the solution approach for the problem, this paper proposes an improved multi-objective variable neighborhood search (IMOVNS) which equipped with an acceptance criterion based on Metropolis criterion as well as an archive update mechanism. Numerical experiments are executed on a set of test instances and the proposed algorithm is evaluated based on four main criteria of multi-objective optimization algorithms, these are: (i) convergence, (ii) uniformity, (iii) cardinality, and (iv) spread of the solutions. The experiment results show the superiority of IMOVNS to the several benchmark algorithms and confirm the trade-off circumstance between material handling cost and safety factor in the considered situation.
The drinking water crises of Flint and Havelock North: a failure of public health risk management
Authors: McLaren S. J. , Sahli M. W. , Selig S. , Masten S. J. , Page W. H. 
Published: August 2022

Abstract
Between 2014 and 2016, there were two severe community water system (CWS) failures in Flint, Michigan (MI), USA and Havelock North, Hawkes Bay, New Zealand. These events had profound implications for public health in their respective countries. While the nature of both crises was different, certain aspects of the failings were strikingly similar. These included: failure of authorities to protect the integrity of their source water,‘wait-and-see approach’ to address problems if and when they occurred,negligent approach to regulatory oversight and responsibility,substandard facilities and lack of knowledge and training of staff,failure of consultants and advisory services engaged by suppliers, andfailure of government agencies to enforce regulations.
The lessons from both incidents must be learned, or similar tragic events are likely to reoccur. The six principles identified in the Government Inquiry into the Havelock North outbreak are an essential first step. The next step is to implement them throughout the drinking water sector.
Use of fresh water over the long run measuring persistence
Authors: del Rio Marta , Infante Juan , Gil-Alana Luis A. 
Published: August 2022

Abstract
In this article, we carry out a study of the degree of persistence of a time series of data on freshwater use in the long term, using fractional integration or I(d) techniques. Using annual data from 1901 to 2014, we observe that the order of integration of the series is close to 1 if the errors are not correlated, and if they are correlated, then it is greater than 1. This shows that the series is highly persistent. On the other hand, we detect two structural breaks, one at 1951 and the other one at 1980. In these cases, we observe a reversion to the mean since the integration orders are much lower in the subsamples. This supports the hypothesis that when these breaks are not taken into account, there is an overestimation of the differentiation parameter, misspecifying the reversion to the mean of the data. The series also shows segmented trends with the higher time trend coefficient observed during the years 1951 and 1980.
Chaperone-Mediated Autophagy: A Potential Target for Metabolic
Diseases
Authors: Yang Ming , Luo Shilu , Chen Wei , Zhao Li , Wang Xi 
Published: August 2022

Abstract:
Autophagy is the process by which cells selectively remove damaged organelles
or proteins. Chaperone-mediated autophagy (CMA) is a type of autophagy that
degrades proteins containing the KFERQ pentapeptide in cells. CMA can degrade damaged
or excess proteins and therefore plays an important role in maintaining protein balance
in cells. CMA can also play a regulatory role by degrading key proteins in life activities,
such as lipid and glucose metabolism. This review introduces the CMA process and
describes the current commonly used CMA detection methods. In addition, we describe
the role of CMA in glucose and lipid metabolism. Finally, we summarize the current role
of CMA in metabolic diseases such as diabetic nephropathy (DN), alcoholic liver disease
(ALD) and nonalcoholic fatty liver disease (NAFLD) and discuss the role of CMA as a
potential therapeutic target for metabolic diseases.
SARS-CoV-2 Infection and C1-Esterase Inhibitor: Camouflage Pattern and New Perspective
Authors: Alexiou Athanasios , Batiha Gaber El-Saber , Al-kuraishy Hayder M. , Al-Gareeb Ali I. , Jalal Naif A. , Kabrah Saeed M 
Published: August 2022

Abstract:In Covid-19, the pathological effect of SARS-CoV-2 infection is arbitrated through direct viral toxicity, unusual immune response, endothelial dysfunction, deregulated renin-angiotensin system [RAS], and thrombo-inflammation, leading to acute lung injury (ALI), with a succession of acute respiratory distress syndrome (ARDS) in critical conditions. C1 esterase inhibitor (C1INH) is a protease inhibitor that inhibits the spontaneous activation of complement and contact systems and kinin pathway, clotting, and fibrinolytic systems. Therefore, targeting the complement system through activation of C1INH might be a novel therapeutic modality in the treatment of Covid-19. Therefore, this study aims to illustrate the potential nexus between C1INH and the pathophysiology of SARS-CoV-2 infection. C1INH is highly dysregulated in Covid-19 due to inflammatory and coagulation disorders. C1INH is up-regulated in Covid-19 and sepsis as an acute phase response, but this increase is insufficient to block the activated complement system. In addition, the C1INH serum level predicts the development of ARDS in Covid-19 patients, as its up-regulation is associated with the development of cytokine storm. In Covid-19, C1INH might be inhibited or dysregulated by SARS-CoV-2, leading to propagation of complement system activation with subsequent uncontrolled immunological stimulation due to activation of bradykinin and FXII with sequential activation of coagulation cascades and polymerization of fibrin. Thus, suppression of C1INH by SARS-CoV-2 infection leads to thrombosis and excessive inflammation due to uncontrolled activation of complements and contact systems.
Bioactivities of Dietary Polyphenols and Their Effects on Intestinal
Microbiota
Authors: Cui Qinghua , Zhang Xiaoping , Shao Junjing , Ni Wenting , Yang Ying , Yan Beibei 
Published: August 2022

Abstract:
The human gut is a complex but stable micro-ecosystem in which the intestinal microbiota
play a key role in human health, the health of the intestine and also affect the ability of the
host to metabolize nutrients. Intestinal microbiota can affect human physiological functions by
regulating host metabolism, immunity and intestinal barrier function. Dysbiosis in the intestinal
microbiota is a crucial stimulus for the development of various diseases, which is associated with
a variety of diseases in the body. The composition and function of intestinal microbiota depend on
the host’s physiological status, genetic makeup, dietary habits, age, and environment, which are
the risk factors for obesity, diabetes, cardiovascular diseases and tumors. Polyphenols are important
plant secondary metabolites with many physiological functions like anti-oxidation, antitumor,
bacteriostasis, cardiovascular and cerebrovascular prevention, and protection of liver and
kidney and so on. A large number of studies have confirmed the benefits of dietary polyphenols to
human health. Polyphenols and their associated metabolites affect intestinal health and the balance
of intestinal microbiota by stimulating the growth of beneficial bacteria and inhibiting the
proliferation of pathogens. This review aims to update the current knowledge and highlight how
the bioactivities of polyphenols can modulate the intestinal microbiota and regulate the mechanisms
of the microbiota, providing a theoretical basis and reference for the scientific and overall
use of polyphenols to prevent and treat intestinal diseases and maintain human intestinal health.
Novel 5-fluoro-6-(4-(2-fluorophenyl)piperazin-1-yl)-2-(4-(4-methylpiperazin-
1-yl)phenyl)-1H-benzo[d]imidazole Derivatives as Promising Urease Inhibitors
Authors: Moghadam Ebrahim Saeedian , Al-Sadi Abdullah Mohammed , Talebi Meysam , Amanlou Massoud , Stoll Raphael , Amini Mohsen , Abdel-Jalil Raid 
Published: August 2022

Background:
Highly pathogenic bacteria colonize and maintain themselves with the aid of an
enzyme called urease. Consequently, inhibiting urease enzymes can be a promising method for preventing
ureolytic bacterial infections.

Objective:
This study aimed at synthesizing and screening a novel series of benzimidazole derivatives.

Methods:
Nine novel benzimidazole derivatives 10α-Ɣ were synthesized and isolated. Their structures
were elucidated by 1H-NMR and IR spectroscopic techniques besides HRMS. The urease inhibition activity
of these compounds was evaluated using the standard urease enzyme inhibition kit. An MTT assay
was performed on the NIH-3T3 cell line to investigate the cytotoxicity profile.

Results:
All benzimidazoles 10α-Ɣ exhibited higher urease inhibition activity (3.06–4.40 μM) than the
reference standards thiourea and hydroxyurea (IC50: 22 and 100 μM, respectively). 10Ɣ-1 and 10α-1 exhibited
the best activity with the IC50 values of 3.06 and 3.13 μM, respectively. Investigation of the cytotoxicity
profile of the target compound showed that all 10α-Ɣ have IC50 values higher than 50 μM on the
tested cell line.

Conclusion:
The results showed that synthesized benzimidazole derivatives could be highly effective as
urease inhibitors.
Sulfones of Pyridinyloxy-Substituted Imidazo[2,1-b][1,3]thiazines: Synthesis, Anti-Inflammatory Activity Evaluation In Vivo and Docking Studies
Authors: Slyvka Nataliia , Saliyeva Lesya , Holota Serhii , Khyluk Dmytro , Tkachuk Victor , Vovk Mykhailo 
Published: August 2022

Background:
Heterocyclic sulfone-bearing small molecules are particularly important objects
in medicinal chemistry. Structure-diversified pyridinyloxy-substituted imidazo[2,1-b][1,3]thiazines are
characterized by satisfactory drug-like parameters and possess significant anti-inflammatory effects in in
vivo studies.

Objective:
Oxidation of a series of 6-(2-pyridinyloxy) imidazo[2,1-b][1,3]thiazines under the action of mchloroperbenzoic
acid with a view to anti-inflammatory activity enhancement and structure optimization.

Methods:
A series of appropriate sulfones was synthesized by the action of m-chloroperbenzoic acid on
6-[(pyridin-2-yl)oxy]-6,7-dihydro-5H-imidazo[2,1-b][1,3]thiazines. The structure of the synthesized
products was confirmed by 1H, 13C NMR, and LC-MS spectra. In vivo anti-inflammatory activity was
studied using carrageenin model of inflammatory oedema on white rats. ADMET parameters of compounds
were evaluated in silico using AdmetSAR. For the most active compounds, docking studies to
COX-1,2, 5-LOX and FLAP were performed.

Results:
It was found that transformation to sulfones could be achieved by soft oxidation at room temperature
for 48 h using the 3-fold excess of oxidant in the presence of sodium hydrogen phosphate. Antiinflammatory
activity screening results revealed that all synthesized sulfones showed significant antiexudative
action with inflammation inhibition index in the range of 37.7 - 48.1%. The compound 2i was
found to be the most active in the experiment, and its activity was equal to the reference drug effect; it
also possesses satisfactory ADMET parameters and high energy of binding to 5-LOX and FLAP.

Conclusion:
The synthesized sulfone 2i is of interest for in-depth studies and further design of new potential
non-steroidal anti-inflammatory agents.
An Investigation of Data Requirements for the Detection of Depression
from Social Media Posts
Authors: Dalal Sumit , Jain Sarika , Dave Mayank 
Published: August 2022

Background:
Only a fraction of the produced social media data is usable in mental health assessment. So the problem of sufficient training data for deep learning approaches arises. Data sufficiency can be presented in terms of number of users or number of posts per user.

Objective:
We examine the data need of machine learning and deep learning models for a practical system and let researcher chose best fitting models depending on the dataset type available with them. We perform distinct experiments to find the effect of these issues on depression classification by various approaches.

Methods:
We explored various machine learning and deep learning techniques on various data set versions, taken from Twitter and Reddit, with varying numbers of users and posts per user. Diagnosed and control users are taken in different ratios to assess the impact of an imbalanced dataset.

Results:
The results reveal that SVM achieved 68% accuracy in depression classification for 70 users each from diagnosed and control group. It decreases for 150 users from each group, but then regains performance for 350 and 550 users from each group.

Conclusion:
Conclusion: We found, mainly, classification accuracy increases with the number of users, number of posts per user and imbalance in the number of diagnosed versus control users. We also found that posts from Reddit have better accuracy compared to tweets.
Kinetika Perubahan Ketengikan (Rancidity) Kacang Goreng selama Proses Penyimpanan
Authors: Maharani Dewi Maya , Bintoro Nursigit , Rahardjo Budi 
Published: August 2022

Rancidity is a damage or change in odor and flavor in the fat or fatty food. As one of the fatty food products, peanut is susceptible to rancidity during storage.The duration of heating oil resulting in changes of peroxide value of oil as a medium frying pan provides quality changes in fried ingredients. Besides that, availability of oxygen in the package would also affect on the rate of the rancidity process. The purpose of this study was to develop a mathematical model of rancidity changes of fried peanuts during storage expressed by increasing the numerical value of its peroxide. The variation of heating oil used were 0, 1, 2 and 3 hours. While the variation of ratio of peanut volume with the packaging material used were 1:6, 5:13 and 10:17. The results showed that the longer the heating oil, the greater the number peroxide as well as the number of results of frying beans. The smaller the volume ratio of peanuts to the packaging used, the greater the rate constant changes in peroxide value fried peanuts or the faster the rancidity of the peanut. The equation of constant rate of change of peroxide value fried peanuts (rancidity) during storage could be expressed by P(t) P0.e (0.17)RS-0.10 Xt.ABSTRAKKetengikan (rancidity) merupakan kerusakan atau perubahan bau dan flavor dalam lemak atau bahan pangan berlemak. Sebagai salah satu produk pangan berlemak kacang rentan terhadap ketengikan selama penyimpanan. Lama pemanasan minyak dapat mengakibatkan perubahan nilai angka peroksidanya, sehingga akan mempengaruhi kualitas pada bahan yang digoreng. Disamping itu ketersediaan oksigen dalam kemasan ditengarai juga akan mempengaruhi terjadinya proses ketengikan. Tujuan penelitian ini untuk mengembangkan model matematis perubahan ketengikan kacang goreng selama penyimpanan yang dinyatakan dengan peningkatan nilai angka peroksidanya. Variasi lama pemanasan minyak yang digunakan adalah 0, 1, 2 dan 3 jam. Sedangkan variasi rasio volume kacang dengan kemasan yang digunakan adalah 1:6, 5:13 dan 10:17. Hasil penelitian menunjukkan bahwa semakin lama pemanasan minyak, maka semakin besar angka peroksidanya demikian juga angka peroksida dari kacang hasil penggorengannya. Semakin kecil rasio volume kacang dengan kemasan yang digunakan, maka semakin besar konstanta laju perubahan angka peroksida kacang goreng atau kacang semakin cepat tengik. Persamaan konstanta laju perubahan angka peroksida kacang goreng (ketengikan) selama penyimpanan dapat dinyatakan dengan P(t) P0.e (0.17)RS-0.10 Xt.
Aktivitas Lipase Indigenous selama Perkecambahan Biji Kakao (Theobroma cacao L.)
Authors: Mayun Permana I Dewa Gde , Indrati Retno , Hastuti Pudji , Suparmo Suparmo 
Published: August 2022

The aim of the research was to find the highest activity of cocoa bean lipase during germination. The lipase activity was determined every day for 10 days germination period. The result indicated that the highest hydrolysis activity of the extracted lipase was found at the 3th day of germination = 0,138 U/gram bean and that of esterification was at 4th day = 0,252 U/gram bean. During germination, bean weight and fat content decreased while water content increased. Free fatty acid and soluble protein were in fluctuation during germination.ABSTRAKPenelitian ini bertujuan untuk mendapatkan aktivitas tertinggi lipase biji kakao selama perkecambahan. Aktivitas lipase dianalisis setiap hari selama 10 hari perkecambahan. Lipase terekstrak menunjukkan aktivitas hidrolisis tertinggi dari perkecambahan 3 hari = 0,138 U/gram biji dan aktivitas esterifikasi pada perkecambahan 4 hari = 0,252 U/ gram biji. Aktivitas esterifikasi lebih tinggi dibandingkan hidrolisis selama perkecambahan. Berat biji, kadar lemak mengalami penurunan selama perkecambahan, sedangkan kadar air mengalami peningkatan. Asam lemak bebas dan protein terlarut berfluktuasi selama perkecambahan.
Potensi Isolat Khamir H10 sebagai Agensia Biologis untuk Pengendalian Mucor piriformis pada Buah Apel
Authors: Widyastuti Sri 
Published: August 2022

The potency of the yeast cell isolate H10 in suppressing post-harvest rot, Mucor piriformis, was studied in the wounds of apple fruit. Spore inoculum at diffierent concentrations were inoculated into the artificially-made wounds of fresh picking apple fruit. There were five replicates of single fruit with 4 wounds each. Fruits were incubated at 20 °C for 4 days. Increasing concentration of the pathogen spores applied in the wounds, produced higher percentage of rot and diameter of lesion. At the concentration of 107 and 108 cfu ml-1, the yeast cells were able to suppress the percentage of infection and diameter of lesion caused by the pathogen up to 65 %. The inhibition activity of the yeast cells was most highest when the yeast applied coincidentally or 2 hours before inoculation of the pathogen inoculum. These evidences indicate that the yeast is potential to be developed as a protective bio-control agent to suppress the development of post-harvest diseases of apple caused by M. piriformis.ABSTRAKPotensi sel khamir isolat H10 untuk menghambat perkembangan jamur patogen pasca panen Mucor piriformis dipela- jari pada luka buatan pada buah apel. Larutan spora pada berbagai konsentrasi diinokulasikan ke dalam luka buatan pada buah apel segar. Setiap perlakuan menggunakan lima buah apel yang masing-masing mempunyai 4 buah luka. Buah kemudian disimpan untuk dihitung persentase infeksi dan diameter luka yang terjadi selama 4 hari penyimpanan pada suhu 20 °C. Meningkatnya konsentrasi spora patogen yang diinokulasikan pada luka, meningkat pula persentase infeksi dan diameter luka. Sel khamir terbukti mampu menggandakan diri pada permukaan jaringan luka. Pada kon- sentrasi 107 dan 108 cfu ml-1, sel khamir dapat secara nyata menghambat perkembangan jamur patogen sampai 65%. Penghambatan tersebut lebih efektif pada sel khamir yang diaplikasikan bersamaan dengan atau 2 jam sebelum inokulasi inokulum spora pathogen. Efektifitas penghambatan pada buah segar lebih tinggi dibanding pada buah yang telah disimpan beberapa lama. Kenyataan tersebut mengisyaratkan bahwa isolat khamir H10 mempunyai potensi dapat dikembangkan menjadi agensia biologis yang bersifat protektif untuk pengendalian penyakit pasca panen buah apel yang disebabkan oleh M. piriformis.
Validity evidence studies of the Regulatory Emotional Self-Efficacy Scale in Brazil
Authors: Porto Noronha Ana Paula , De Medeiros Maciel Ana Cecília , Angeli dos Santos Acácia , Gurgel Azzi Roberta 
Published: August 2022

Self-efficacy for emotion regulation is understood as the perceived capability to regulate the negative affect and to express the positive ones. This study aimed at the validity evidence for the Regulatory Emotional Self-Efficacy Scale in the Brazilian context through two studies. In the first one, participants were 41 students from middle school (M = 13.49; SD = 1.52), being 58.5 % male. Results indicated a few adjustments in some items. The second study had 932 participants from two cities: one from Southeast Brazil and one from the North. The students were from middle and high schools being 50.3 % (n = 469) female. Their ages ranged from 13 to 23 years old (M = 16.50; SD = 1.52). After analysis through structural equation modeling, results indicated that the dimensions of the scale have a good fit according to the theoretical model with good accuracy indexes, thus confirming the validity evidence for this instrument, being reliable to be used in Brazil.