bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bird–building collisions increase with weather conditions that favor nocturnal migration and with inclement and changing weather
Authors: Lao Sirena , Anderson Abigail W , Blair Robert B , Eckles Joanna W , Turner Reed J , Loss Scott R 
Published: November 2022

AbstractCollisions with building windows are a top bird mortality source, but few studies have evaluated how bird–window collisions are influenced by weather. By monitoring collisions daily at 21 buildings in Minneapolis, Minnesota, over 4 migration seasons, we show that weather influences numbers of window collisions of nocturnal migrants in spring and fall, indicating that collisions may be forecastable based on weather conditions. Collisions increased with weather favoring migration, such as consecutive nights of south wind in spring and even short periods of north wind in fall. We also found evidence that spring and fall collisions increase with weather changes that impede migration, such as changes from fair conditions and tailwinds early in the night to headwinds near sunrise. Our study suggests complex weather effects never before considered in the context of bird collisions, including possible time lag effects of conditions 2–3 nights before collisions occur, effects of multi-day sequences of conditions, and interactions between conditions at different times of night. More research is needed to determine if the accuracy of weather-based collision prediction systems improves by integrating such nuances and to clarify mechanisms through which these complex effects operate, such as influences of weather on migration intensity and collision avoidance behavior. Weather-based forecasts may allow refinement of collision mitigation approaches (e.g., reducing building lighting on certain nights or using temporary glass coverings or treatments). However, because challenges remain to communicating such temporally targeted actions and implementing them in a timely manner, other bird-friendly practices (e.g., season-long lighting reduction and permanent glass treatments) should continue to be prioritized.
Low incidence of neurological recurrent side-effects following COVID-19 reimmunization
Authors: Koh Jasmine Shimin , Hoe Rebecca Hui Min , Chen Geraldine Jiangyan , Goh Yihui , Tan Benjamin Y Q , Yong Ming Hui , Hui Andrew Che-Fai , Tu Tian Ming , Yong Kok Pin , Angon Jasmyn , Tan Kevin , Quek Amy May Lin , Umapathi Thirugnanam , Seet Raymond Chee Seong 
Published: November 2022

SummaryBackgroundIndividuals who suffered a neurological adverse event after the Coronavirus disease (COVID-19) vaccine could hesitate and defer reimmunization.AimWe examine the risk of recurrence following reimmunization among patients who developed a neurological event after the first dose of the COVID-19 mRNA vaccine.DesignObservational study.MethodsIndividuals who developed an adjudicated neurological adverse event (based on Brighton Collaboration criteria) within 6 weeks of the first dose of the COVID-19 vaccine requiring hospitalization were enrolled into a multicenter national registry in Singapore. Neurological recurrence, defined by the development of another neurological event within 6 weeks of the second vaccine dose, was reviewed. Clinical characteristics were compared between patients who chose to proceed or withhold further vaccination, and between those who received timely (3–6 weeks) or delayed (&gt;6 weeks) reimmunization.ResultsFrom 235 patients (median age, 67 years; 63% men) who developed an adjudicated neurological event after their first dose of mRNA vaccine between 30 December 2020 and 20 April 2021, 181 (77%) chose to undergo reimmunization. Those who decided against reimmunization were older (median age, 74 vs. 66 years) and had greater physical disability following their primary neurological event (46% vs. 20%, P &lt; 0.001). Patients who suffered greater physical disability were three times more likely to delay their reimmunization (odds ratio 3.36, 95% confidence interval: 1.76–6.40). Neurological recurrence was observed in only four individuals (three with seizures and one with myasthenia gravis exacerbation).ConclusionsA prior neurological event should not necessarily preclude reimmunization and the decision to proceed with reimmunization should consider the overwhelming benefits conferred by vaccination toward ending this pandemic.
Improving outcomes in scleroderma: recent progress of cell-based therapies
Authors: Khanna Dinesh , Krieger Nancy , Sullivan Keith M 
Published: November 2022

Abstract
Scleroderma is a rare, potentially fatal, clinically heterogeneous, systemic autoimmune connective tissue disorder that is characterized by progressive fibrosis of the skin and visceral organs, vasculopathy and immune dysregulation. The more severe form of the disease, diffuse cutaneous scleroderma (dcSSc), has no cure and limited treatment options. Haematopoietic stem cell transplantation has emerged as a potentially disease-modifying treatment but faces challenges such as toxicity associated with fully myeloablative conditioning and recurrence of autoimmunity. Novel cell therapies—such as mesenchymal stem cells, chimeric antigen receptor-based therapy, tolerogenic dendritic cells and facilitating cells—that may restore self-tolerance with more favourable safety and tolerability profiles are being explored for the treatment of dcSSc and other autoimmune diseases. This narrative review examines these evolving cell therapies.
Formulation of resveratrol into PGA-co-PDL nanoparticles increases its cytotoxic potency against lung cancer cells
Authors: Muller Ashley G , Sarker Satyajit D , Fatokun Amos A , Hutcheon Gillian A 
Published: November 2022

Abstract

Objectives
Lung cancer is the commonest cause of cancer-related deaths, and current treatment involves the use of cytotoxic drugs that have many unwanted side effects. Resveratrol, a natural polyphenol, has promising anticancer efficacy, but its therapeutic application is hindered by low bioavailability, which the present study sought to improve through encapsulation into nanoparticles (NPs).

Methods
Resveratrol was loaded into poly(glycerol adipate-co-ω-pentadecalactone) (PGA-co-PDL; MWt 16.5 KDa) NPs with sizes 220–230 nm, and tested against Calu-3 human lung cancer cells.

Key findings
About 5% and 10% resveratrol nanoparticles (RNPs) had a high encapsulation efficiency of 78 ± 0.24% and 70 ± 0.89% and a drug loading of 39 ± 0.12 µg and 70 ± 0.89 µg (w/w), respectively. The PGA-co-PDL blank NP (BNP) at 1 mg/ml had good cytocompatibility when Calu-3 cells were exposed to it for 24 h (cell viability of 87.5 ± 4.7%). Remarkably, the 5% RNP and 10% RNP lowered, up to 80%, the IC50 for 24 h cytotoxicity of resveratrol against the cells, from 158 ± 16 µM to 32 ± 10 µM and 70 ± 13 µM, respectively.

Conclusions
Loading of resveratrol into PGA-co-PDL NPs increases its anticancer potency, thus enhancing its prospect for treating lung cancer.
Identificational Orientations among Three Generations of Migrants in France
Authors: Okai Ewurama A , Behrman Julia A 
Published: November 2022

AbstractScholarship on migrant identity increasingly shows that migrants can—and often do—construct multifaceted identities. Yet, questions around migrant identity formation remain contested in France, given a strongly assimilationist policy context that (in theory) precludes multiple identification. This paper explores intergenerational patterns of migrant identification in France using a nationally representative sample of 1st-, 1.5th-, and 2nd-generation migrants in France from five diverse sending regions in the Trajectories and Origin Survey. We conduct a latent profile analysis to identify qualitatively different unobserved (or latent) categories of migrant identification based on observed responses to questions of identification and belonging. These analyses suggest there are five distinct “identificational orientations” among migrants: assimilated, active bicultural, othered bicultural, detached bicultural, and ethnic. While the assimilated and ethnic categories provide some support for a traditional assimilation framework, biculturalism is widely prevalent and multifaceted: We identify three distinct varieties of biculturalism (active, othered, and detached). We also provide evidence of segmentation in identificational assimilation by region of origin and conduct multivariate analyses that shed insight into the experiences that correlate with different identificational orientations. Our findings question the presumed threat of strong ethnic identification to France’s national cohesion and offer starting points for future research on how complex identities are formed within strongly assimilationist receiving contexts like France.
Effect of smartphone-based cognitive behavioral therapy app on insomnia: a randomized, double-blind study
Authors: Watanabe Yosuke , Kuroki Taiyo , Ichikawa Daisuke , Ozone Motohiro , Uchimura Naohisa , Ueno Taro 
Published: November 2022

AbstractStudy ObjectivesThis study assessed the effects and safety of the smartphone-based cognitive behavioral therapy for insomnia (CBT-I) app compared with the sham app.MethodsIn this multicenter, double-blind, and parallel-group study, 175 patients with insomnia were randomized to a smartphone-based CBT-I app (Active, n = 87) or a sham app (Sham, n = 88) group. The primary endpoint was the change in Athens Insomnia Score (AIS) from baseline after 8 weeks of treatment.ResultsThe change in AIS (mean ± standard deviation) from baseline, assessed using a modified-intent-to-treat analysis, was −6.7 ± 4.4 in the Active group and −3.3 ± 4.0 in the Sham group. The difference in the mean change between the groups was −3.4 (p &lt; .001), indicating a greater change in the Active group. The change in CGI-I from the baseline was 1.3 ± 0.8 in the Active group and 0.7 ± 0.8 in the Sham group (p &lt; .001). The proportion of patients with an AIS less than 6 was 37.9% in the Active group and 10.2% in the Sham group (p &lt; .001). As for the safety assessment, no adverse reactions or device failures were detected in the Active group.ConclusionsThis study demonstrated the effectiveness of a smartphone-based CBT-I system for treating insomnia.Clinical Trial RegistrationID: jRCT2032210071; trial name: Sham (software)-controlled, multicenter, dynamic allocation, double-blinded study of non-medication therapy with a software Yukumi in patients with insomnia disorders (verification study); URL: https://jrct.niph.go.jp/en-latest-detail/jRCT2032210071
The Churches They Are a Changin’: Processes of Change in Worship Services
Authors: Roso Joseph 
Published: November 2022

AbstractOne of the most significant recent changes in American religious congregations is the shift toward more enthusiastic worship practices. Despite how clear and significant this trend is, the processes by which worship services have become more enthusiastic remain unclear. I address this question using linear decomposition techniques with data from the National Congregations Study—a nationally representative repeated cross-sectional survey of American religious congregations. Drawing from theories of population ecology, organizational adaptation, and institutions, I identify two distinct processes by which the population of congregations is incorporating more enthusiastic worship practices: (1) new congregations that are disproportionately nondenominational or evangelical are entering the population with highly enthusiastic worship practices, and (2) older congregations across all traditions are changing their worship to incorporate more enthusiastic practices. Because most congregations are older, the second process accounts for most of the change in the population. These findings help advance our understanding of how the population of religious congregations is changing in the 21st century.
Ethnic differences in hepatitis A and E virus seroprevalence in patients attending the Emergency Department, Paramaribo, Suriname
Authors: Mac Donald-Ottevanger M S , Prins Maria , van Dissel Jaap , Rier Neela , Reimerink Johan , Zijlmans Wilco C W R , Vreden Stephen G S , Boyd Anders 
Published: November 2022

AbstractBackgroundHepatitis A virus (HAV) and hepatitis E virus (HEV) have enteric modes of transmission and are common causes of acute hepatitis in low- and middle-income countries. HEV is also characterised as a zoonotic infection and is prevalent in high-income countries. Data on HAV and HEV prevalence in Suriname, a middle-income country in South America, are scarce.MethodsSerum samples of 944 and 949 randomly selected patients attending the Emergency Department at the Academic Hospital of Paramaribo, the capital of Suriname, were analysed for anti-HAV antibodies (anti-HAV) and anti-HEV antibodies (anti-HEV), respectively. Determinants of anti-HAV and anti-HEV positive serology were evaluated using multivariable logistic regression.ResultsAnti-HAV prevalence was 58.3% (95% CI 55.4 to 61.4%) and higher prevalence was independently associated with belonging to the Tribal or Indigenous population and older age. Anti-HEV prevalence was 3.7% (95% CI 2.6 to 5.0%) and higher prevalence was associated with Tribal and Creole ethnicity and older age.ConclusionsIn Suriname, exposure to HAV is consistent with a very low endemic country and exposure to HEV was rare. Both viruses were more prevalent in specific ethnic groups. As anti-HAVantibodies were less frequently found in younger individuals, they could be susceptible to potential HAV outbreaks and might require HAV vaccination.
Trends in NIH Funding to Medical Schools in 2011 and 2020
Authors: Roskoski Robert 
Published: November 2022

PurposeTo examine trends in National Institutes of Health (NIH) funding to U.S. medical schools and their academic departments and the amount of awards provided by each of the NIH institutes.MethodAll data on NIH awards to U.S. medical schools from 2000 to 2020 are publicly available and were obtained from the NIH Research Portfolio Online Reporting Tools and Blue Ridge Institute for Medical Research. These data include the value and number of awards to each medical school, medical school department, medical school location, principal investigator, and the NIH awarding institute. Trends in the inflation-adjusted awards from 2011 to 2020 were calculated and a comparison of the awards made in 2011 and 2020 was performed.ResultsThe total NIH budget increased by 16.1% from 2011 to 2020. The allocation of NIH funds to medical schools increased 26.3% ($13.7 billion to $17.3 billion) during this interval. In 2020, 29.3% of all medical school NIH funds were allocated to departments of internal medicine/medicine. Psychiatry was the second ranking department, which was followed, in order, by pediatrics, neurology, and microbiology/immunology/virology. The National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Heart, Lung, and Blood Institute were the top medical school funding institutes in 2011 and 2020. Medical schools as a group continue to receive the greatest percentage of NIH funding. Funding to clinical science departments increased by a larger percentage than that to basic science departments (35.3% vs 10.9%, respectively) over the 2011–2020 interval.ConclusionsFunding for clinical science departments is increasing at a faster rate than that of basic science departments. However, that so much investigation in basic science and clinical science departments is performed by personnel with a PhD degree indicates the goals and methods of the basic and clinical sciences may not be so different.
Efficacy of Technical Modifications to the Associating Liver Partition and Portal Vein Ligation for Staged Hepatectomy (ALPPS) Procedure
Authors: Khajeh Elias , Ramouz Ali , Dooghaie Moghadam Arash , Aminizadeh Ehsan , Ghamarnejad Omid , Ali-Hassan-Al-Saegh Sadeq , Hammad Ahmed , Shafiei Saeed , Abbasi Dezfouli Sepehr , Nickkholgh Arash , Golriz Mohammad , Goncalves Gil , Rio-Tinto Ricardo , Carvalho Carlos , Hoffmann Katrin , Probst Pascal , Mehrabi Arianeb 
Published: November 2022

Objectives:
To compare the outcomes of modified-Associating Liver Partition and Portal vein Ligation for Staged hepatectomy (ALPPS) techniques with those of conventional-ALPPS.

Background:
ALPPS is an established technique for treating advanced liver tumors.

Methods:
PubMed, Web of Science, and Cochrane databases were searched. The outcomes were assessed by single-arm and 2-arm analyses.

Results:
Seventeen studies containing 335 modified-ALPPS patients were included in single-arm meta-analysis. The estimated blood loss was 267 ± 29 mL (95% confidence interval [CI], 210–324 mL) during the first and 662 ± 51 mL (95% CI, 562–762 mL) during the second stage. The operation time was 166 ± 18 minutes (95% CI, 131–202 minutes) during the first and 225 ± 19 minutes (95% CI, 188–263 minutes) during the second stage. The major morbidity rate was 14% (95% CI, 9%–22%) after the first stage. The future liver remnant hypertrophy rate was 65.2% ± 5% (95% CI, 55%–75%) and the interstage interval was 16 ± 1 days (95% CI, 14–17 days). The dropout rate was 9% (95% CI, 5%–15%). The overall complication rate was 46% (95% CI, 37%–56%) and the major complication rate was 20% (95% CI, 14%–26%). The postoperative mortality rate was 7% (95% CI, 4%–11%). Seven studies containing 215 patients were included in comparative analysis. The hypertrophy rate was not different between 2 methods (mean difference [MD], –5.01; 95% CI, –19.16 to 9.14; P = 0.49). The interstage interval was shorter for partial-ALPPS (MD, 9.43; 95% CI, 3.29–15.58; P = 0.003). The overall complication rate (odds ratio [OR], 10.10; 95% CI, 2.11–48.35; P = 0.004) and mortality rate (OR, 3.74; 95% CI, 1.36–10.26; P = 0.01) were higher in the conventional-ALPPS.

Conclusions:
The hypertrophy rate in partial-ALPPS was similar to conventional-ALPPS. This shows that minimizing the first stage of the operation does not affect hypertrophy. Moreover, the postoperative overall morbidity and mortality rates were lower following partial-ALPPS.
Experiences of Mothers Living With HIV in a South African Prevention of Mother-to-Child Transmission of HIV Programme: A Qualitative Descriptive Study
Authors: Velapi Linda , Mayers Pat M. , Frantz Jose 
Published: November 2022

Abstract
More than 90% of all HIV infections in children result from mother to child transmission. Elimination of mother–child transmission is a global priority and vital for the improvement of child survival in high-burden, limited resource settings. Retention in HIV care is vital to reduce transmission risk. This qualitative study explored the experiences and adherence challenges of mothers living with HIV of the Prevention of Mother-to-Child Transmission of HIV (PMTCT) programme in Khayelitsha, Cape Town, South Africa. Interviews were conducted with purposively selected participants enrolled in a PMTCT programme at a primary care facility. Thematic analysis generated six themes. Findings demonstrate the complexity of living as a woman with HIV in a socioeconomically disadvantaged and marginalized periurban community. For each woman, there is a set of concerns relating to person, home, community, and clinic which may affect her understanding, acceptance of, and adherence to the PMTCT programme.
Impact of Preadmission Observation Hours on Key Physical Therapist Clinical Education Stakeholders: Quantitative Analysis
Authors: Bayliss Jamie , Schack-Dugre Judi , Hoang Thuha , Watkins Molly , Mitchell Katy , Mariano Mira , Greco Jamie , Colgrove Yvonne , Wheeler Emma , Kiyota Hiroshi , Pientok Colette , Stephens Laura , McCarthy Casey , McBride Gavin , Gleeson Peggy 
Published: November 2022

Introduction and Review of Literature.
Physical therapist (PT) and PT assistant (PTA) education programs have historically required preadmission observation hours (ObHr) as an admission requirement. The variability of conditions surrounding ObHr lends itself to investigation. The aims of this study were to (1) identify the perceived value of ObHr to Admission Committee (AC) members, Directors of Clinical Education, current Doctor of Physical Therapy (DPT) students, and PT clinicians, (2) examine the effect that ObHr have on the decision-making process of AC members, and (3) examine the effect that ObHr had on current DPT students’ decisions to pursue a PT career.

Subjects.
Four stakeholder groups were targeted (N = 4,471).

Methods.
This descriptive, cross-sectional study utilized surveys to collect quantitative and qualitative data through closed-ended and open-ended questions. This article encompasses the analysis of the quantitative components by analyzing fixed responses on stakeholder surveys. Qualitative findings are reported in a separate article.

Results.
Perceived purposes of ObHr by stakeholders were as follows: (1) to gain an accurate understanding of the depth and breadth of the profession, (2) to confirm a desire to pursue PT as a profession, and (3) to better understand the roles and responsibilities of PT. The number of necessary ObHr varied among the groups ranging from 0 to 100 hours. Student perception that completing more hours than required would assist in their favorability for acceptance was debunked.

Discussion.
There was consensus among all groups regarding the perceived purposes. Variability of stakeholder perception of necessary ObHr to achieve goals was revealed. Doctor of Physical Therapy programs should be transparent and clarify the purpose and quantity of required ObHr.

Conclusion.
Long-standing requirements could be taxing current resources and limiting entry into the profession. Determining the minimum number of necessary ObHr, considering virtual methods, and employing distinct transparency on how ObHr are used in the decision-making process are opportunities for further study to address these issues.
Naloxone Prescribing Associated With Reduced Emergency Department Visits in the Military Health System
Authors: Costantino Ryan C. , Tilley Laura C. , Gressler Laura Elisabeth , Zarzabal Lee Ann , Vasquez Cynthia M. , Peters Sidney , Pakieser Jennifer , Highland Krista B. , dosReis Susan 
Published: November 2022

Purpose:
The aim was to determine the association between the receipt of naloxone and emergency department (ED) visits within 60 days after the receipt of an opioid.

Methods:
A retrospective cohort of individuals 18 years of age or above, enrolled in TRICARE, and were dispensed an opioid at any time from January 1, 2019, through September 30, 2020 was identified within the United States Military Health System. Individuals receiving naloxone within 5 days of the opioid dispensing date were propensity score matched with individuals receiving opioids only. A logistic regression was used to estimate the odds of an ED visit in the 60-day follow-up period after the index opioid dispense event among those co-dispensed naloxone and those receiving opioids only.

Results:
Of the 2,136,717 individuals who received an opioid prescription during the study period, 800,071 (10.1%) met study inclusion criteria. Overall, 5096 (0.24%) of individuals who received an opioid prescription were co-dispensed naloxone. Following propensity score matching, those who received naloxone had a significantly lower odds of ED utilization in the 60 days after receiving an opioid prescription (odds ratio: 0.74, 95% CI: 0.68–0.80, P<0.001).

Conclusion:
This study highlights the importance of expanding access to naloxone in order to reduce ED utilization. Future research is needed to examine additional outcomes related to naloxone receipt and develop programs that make naloxone prescribing a routine practice.