bluuebunny/crossref_metadata_2025_split huggingface dataset:
Revision Total Hip Arthroplasty with Severe Acetabular Defect: A Preliminary Exploration and Attempt of Robotic‐Assisted Technology
Authors: Zhang Shuai , Liu Yu‐bo , Ma Ming‐yang , Cao Zheng , Kong Xiang‐peng , Chai Wei 
Published: July 2022

BackgroundRobotic‐assisted technology may be useful in hip revision cases with acetabular defects. However, data on the use of robotic‐assisted technology for such complex diseases is lacking.Case PresentationThis case study described the adoption of MAKO robotic‐assisted treatment of revision total hip arthroplasty (THA) combined with severe acetabular defect (Paprosky type IIIB). Robotic‐assisted technology accurately achieved preoperative planning; the acetabular component and augment were placed in the original position and angle as planned. Robotic‐assisted acetabular reaming was successful in a single pass, preserving the remaining acetabular bone mass very well with no procedure‐related complications. The Harris Hip Score (HHS) at 6 months postoperatively was 84 and the Western Ontario and McMaster Universities (WOMAC) Osteoarthritis Index was 24.ConclusionRobotic‐assisted technology can help in the accurate reconstruction of acetabular defect in complex hip revision surgery.
Hiding in the open: Consideration of nonsuicidal self‐injury by proxy as a clinically meaningful construct
Authors: Mann Adam J. D. , Tull Matthew T. , Gratz Kim L. 
Published: July 2022

AbstractNonsuicidal self‐injury (NSSI) is defined as the deliberate destruction of one's own body tissue without suicidal intent and for purposes not socially sanctioned. However, this definition limits the understanding and assessment of NSSI by excluding a clinically relevant form of NSSI that is both self‐driven and associated with self‐injurious intentions: NSSI by proxy. Specifically, we propose that NSSI by proxy be defined as the intentional destruction of one's own body tissue through the elicitation of another being's (e.g., human, animal) actions, wherein the agency of the person being injured is a critical facet of the behavior. We review the literature supporting the clinical relevance of this behavior, as well as its similarities to traditional NSSI. Next, we propose four behaviors that may be conceptualized as NSSI by proxy, and identify two other behaviors that warrant further investigation. Finally, we identify future directions for research in this area and implications for the assessment and treatment of NSSI.
The industrialisation thesis, revisited: Understanding welfare expansion in China through social expenditure data (2000–2019)
Authors: Hong Ijin , Ngok Kinglun 
Published: July 2022

AbstractChina is undergoing important reforms in its welfare system, and some scholars agree that a new ‘social policy era’ took place in the 2000s–2010s. Although welfare development theories—typically, the industrialisation thesis and the power resources approach—are well established in social policy research, welfare change and its determinants in China are still poorly understood in international literature. Making use of official statistics at the provincial level, this study examines whether industrialisation is associated with welfare development in China during the ‘social policy era’ (2000–2019). We contribute to welfare development literature by, first, measuring welfare effort in China while addressing comparability issues (the ‘dependent variable problem’); and, secondly, testing the industrialisation thesis, amongst others, through a fixed‐effects time‐series‐cross‐section data analysis on provincial‐level statistics covering 30 provinces during 20 time points (2000–2019). Results show that the industrialisation theory is indeed important for welfare development in China, but several less‐developed provinces also experienced substantial improvement in their welfare spending irrespective of their local revenues, suggesting that redistribution at the level of the central government and political reform are increasingly important topics for future welfare studies in China.
Redefining weeds for the post‐herbicide era
Authors: Merfield Charles N. 
Published: July 2022

AbstractIn the 50th edition of Weed Research the Editor‐in‐Chief introduced the concept of ‘the post‐herbicide era’. This appears increasingly prescient as herbicides continue to face ever‐increasing legislative restrictions and evolved resistance. They are also an important enabler of intensive agriculture which is a key contributor to the planetary crises, such as climate change and biodiversity loss. Integrated weed management (IWM) is the clear direction of travel for both weed science and practice, and is increasingly being holistically integrated into overall crop management. However, most definitions of ‘weeds’ date from the era of intensive agriculture, so may not be suitable for the post‐herbicide era and IWM. It is argued that deciding if a plant is a weed is fundamentally a ‘value judgement’, so weeds are, therefore, ethical and social constructs, and not a scientific concept. The proposed definition is ‘A plant, or population of plants, in a specific time and place, causing significant harm, either immediately or in the longer term, based on a holistic analysis of both their positive and negative attributes’. Thus, plants are defined as weeds on a case‐by‐case basis, that is, at a specific time and place, which counters the belief that a particular plant species are weeds. Significant harm is the value statement at the heart of the definition. As seedbanks and living plants persist from year to year and plants can become invasive, a caveat about the harm being in the future is required. The analysis of harm must also be holistic, for example, consider all ecosystem services that the plants provide. ‘Other plants’ or ‘aliae plantae’ are suggested to describe non‐crop plants that are not weeds that this definition creates.
Slow-Speed Compared With Fast-Speed Eccentric Muscle Actions Are Detrimental to Jump Performance in Elite Soccer Players In-Season
Authors: Segers Nick , Waldron Mark , Howe Louis P. , Patterson Stephen D. , Moran Jason , Jones Ben , Kidgell Dawson J. , Tallent Jamie 
Published: July 2022

Purpose: To examine the effect of fast- versus slow-speed eccentric-muscle-action resistance training on lower-body strength, vertical jump height, sprint speed, and change-of-direction performance in elite soccer players during a competitive season. Methods: Twenty-two elite soccer players, from a single team, were randomly assigned to groups that undertook either 1- (fast speed) or 4-second (slow speed) eccentric resistance training during the in-season period. A 5-week program was conducted during an elite top-division European League soccer season. Performance measures including predicted 1-repetition-maximum back squat, countermovement jump, 20-m sprint, and change of direction were tested before and after the intervention period. Total match and training running distance and muscle soreness were also recorded during each week of the intervention. Results: An analysis of covariance showed significant group effects (P = .01) for countermovement jump with a greater jump height in the 1-second fast-speed group postintervention (95% CI, 1.1–6.9 cm). Despite an overall increase in 1-repetition maximum pretraining to posttraining (95% CI, 10.0–15.3 kg, effect size 0.69), there were no significant differences (P > .05) between groups after the intervention. Similarly, there were no differences between groups for change of direction, 20-m sprint, or muscle soreness. Conclusion: Faster eccentric muscle actions may be superior for increasing movements in elite soccer players in-season.
Reducing Screen-Based Sedentary Behavior Among Overweight and Obese Hispanic Adolescents Through a Family-Based Intervention
Authors: Perrino Tatiana , Brincks Ahnalee M. , Estrada Yannine , Messiah Sarah E. , Prado Guillermo 
Published: July 2022

Background: Sedentary behaviors, including screen-based activities, are associated with obesity, cardiovascular, and mental health risks. In the US, minority and socioeconomically disadvantaged youth engage in substantial sedentariness, requiring targeted interventions. Familias Unidas for Health and Wellness (FUHW) is a family intervention to reduce risks among Hispanic youth with overweight and obesity. Analyses examined (1) FUHW’s impact on parent and adolescent screen-based sedentary behavior and (2) differential intervention effects by adolescent gender, internalizing symptoms, and body mass index. Methods: A total of 280 overweight/obese Hispanic middle schoolers and parents were randomized to FUHW or control and assessed at baseline, 6, 12, and 24 months between 2015 and 2019. Results: Linear growth models showed that exposure to FUHW was not associated with parent sedentary behavior over time (b = −0.11, P = .32) but was associated with decreases in adolescent sedentary behavior (b = −0.27, P = .03). Neither gender nor internalizing symptoms moderated intervention effects, but there were differential effects by body mass index. Compared to controls, FUHW showed significant decreases in sedentary behavior among overweight (b = −0.85, P < .01) and obese (b = −0.79, P < .01) youth but not severely obese youth. Conclusions: FUHW reduced youth screen-based sedentary behavior. Youth with severe obesity require additional intervention.
Bone Turnover Markers and Osteokines in Adolescent Female Athletes of High- and Low-Impact Sports Compared With Nonathletic Controls
Authors: Kottaras Steven , Stoikos Joshua , McKinlay Brandon J. , Ludwa Izabella A. , Josse Andrea R. , Falk Bareket , Klentrou Panagiota 
Published: July 2022

This study examined differences in resting concentrations of markers of bone formation and resorption, and osteokines between female adolescent (12–16 y) swimmers, soccer players, and nonathletic controls. Resting, morning blood samples were obtained after an overnight fast from 20 swimmers, 20 soccer players, and 20 nonathletic controls, matched for age. carboxyl-terminal cross-linking telopeptide of type I collagen (CTX), amino-terminal propeptide of type I collagen (P1NP), total osteocalcin (OC), sclerostin, osteoprotegerin (OPG), and receptor activator of nuclear factor kappa B ligand (RANKL) were analyzed in serum. After controlling for percent body fat, there were no significant differences between swimmers and nonathletic controls in any of the measured markers. In contrast, soccer players had significantly higher P1NP (89.5 [25.6] ng·mL−1), OC (57.6 [22.9] ng·mL−1), and OPG (1052.5 [612.6] pg·mL−1) compared with both swimmers (P1NP: 66.5 [20.9] ng·mL−1; OC: 24.9 [12.5] ng·mL−1; OPG: 275.2 [83.8] pg·mL−1) and controls (P1NP: 58.5 [16.2] ng·mL−1; OC: 23.2 [11.9] ng·mL−1; OPG: 265.4 [97.6] pg·mL−1), with no differences in CTX, sclerostin, and RANKL. These results suggest that bone formation is higher in adolescent females engaged in high-impact sports like soccer compared with swimmers and controls.
Ophthalmologists’ and patients’ perspectives on treatments for diabetic retinopathy and maculopathy in Vietnam: a descriptive qualitative study
Authors: Curran Katie , Lohfeld Lynne , Congdon Nathan , Peto Tunde , Hoang Tung Thanh , Nguyen Hue Thi , Nguyen Quan Nhu , Nguyen Van Thu , Dardis Catherine , Tran Hoang , Tran Hoang Huy , Vu Anh Tuan , Tung Mai Quoc 
Published: July 2022

IntroductionGlobally, diabetic retinopathy (DR) is the leading cause of blindness in working-aged adults. Early detection and treatment of DR is essential for preventing sight loss. Services must be available, accessible and acceptable to patients if we are to ensure they seek such care.ObjectivesTo understand patients’ knowledge and attitudes towards laser versus antivascular endothelial growth factor (VEGF) injections to treat DR in Vietnam, and to identify factors Vietnamese ophthalmologists consider when making treatment decisions.MethodsThis is a descriptive qualitative study based on semi-structured interviews with 18 patients (12 from Ho Chi Minh City and 6 from Hanoi) plus individual interviews with 24 ophthalmologists working in eye clinics in these cities. Thematic analysis was used to analyse the data.ResultsIn total, 10/24 (41.7%) ophthalmologists were female, and their median age was 41 years (range 29–69 years). The median age of patients was 56.5 years (range 28–72 years), and 7/18 (38.9%) were female. Briefly, factors that influence DR treatment decisions for ophthalmologists are medical considerations (ie, severity of disease, benefits and risks), availability (ie, treatment and resources) and patient-related factors (ie, costs and adherence). Patient’s perceived barriers and facilitators to treatments were based on patient and family related factors (ie, treatment and transportation costs) and previous treatment experiences (ie, positive and negative). Recommendations by all participants included ensuring that both laser and anti-VEGF injections are widely available across the country and controlling costs for patients and the healthcare system.ConclusionsReducing DR treatment costs, optimising treatments options, and expanding the network of clinics offering treatment outside metropolitan areas were the main issues raised by participants. These findings can help inform policy changes in Vietnam and may be generalisable to other low-resource settings.
Pivotal role of environmental toxicants on developing infectious diseases in LMICs: a protocol for a systematic review and meta-analysis
Authors: Sarah Rehnuma Haque , Shariful Islam Md , Zamiur Rahaman Md , Afrin Sadia , Rahman Mahbubur , Saif-Ur-Rahman K M 
Published: July 2022

IntroductionEnvironmental toxicants such as chemical pollution have an enormous impact on the health of people and the planet. Emerging findings suggest that non-communicable diseases are linked to early and chronic environmental exposures. However, the rapid globalisation in developing countries, environmental change and the emergence, spread, persistence and severity of infectious diseases are not yet well understood. The aim of this study is to understand which environmental toxicants are commonly associated with infectious diseases in low-income and middle-income countries (LMICs).Methods and analysisA total of four electronic databases, MEDLINE through PubMed, Scopus, Web of Science and CENTRAL (the Cochrane Library) be searched to identify relevant studies and will be screened by two independent reviewers. The Cochrane risk of bias (ROB) tool for randomised control trials (RCTs) and ROB assessment tool for non-randomised studies for non-RCTs will be used to assess the ROB. A meta-analysis will be used to determine the pooled effect if we find out the included articles have similar environmental exposure, participant groups, study design and outcome measures. A narrative synthesis of the findings will be provided, along with summaries of the intervention effect. Heterogeneity between the studies will be assessed, and sensitivity analysis will be conducted based on study quality.Ethics and disseminationFindings will be summarised in a single manuscript. This review attempts to explore the pivotal role of environmental toxicants in predisposing, developing, persistent and severity of infectious diseases in LMICs. Findings from this study will highlight the effects of individual environmental toxicants’ role on infectious disease outcomes for the early prevention and limit toxic exposure to guide individual, community, and occupational health policy for future strategies.PROSPERO registration numberCRD42021274359.
Natural high-avidity T-cell receptor efficiently mediates regression of cancer/testis antigen 83 positive common solid cancers
Authors: Li Qingyang , Hu Wei , Liao Baoyi , Song Chanchan , Li Liangping 
Published: July 2022

BackgroundT-cell receptor-engineered T cells (TCR-Ts) have achieved encouraging success in anticancer clinical trials. The antigenic targets, however, were primarily focused on human leukocyte antigen (HLA) A*02:01 restricted epitopes from a few cancer/testis antigens (CTAs) which are not widely expressed in common solid cancers; the tested T-cell receptors (TCRs) were frequently from tumor-infiltrating lymphocytes of old patients and were not assured to have higher avidity. Here, we propose the isolation of high-avidity TCRs against CTAs that are frequently expressed in common solid cancers.MethodsWe selected the CT83 protein, which is frequently expressed in common solid cancers, as a model antigen for screening of its specific TCR. The predicted CT83 epitopes with strong or weak binding to HLA-I molecules, popular in the Chinese population, were integrated into three synthetic long peptides. CT83 reactive CD8+ T cells were stimulated with peptide-loaded dendritic cells (DCs) and sorted using the CD137 biomarker for single-cell sequencing to obtain the paired TCRαβ sequence. The higher frequency TCRs were reconstructed for characterization of the CT83 epitope and for assessment of in vitro and in vivo antitumor activities.ResultsCT83 reactive T cells from young healthy donors (YHDs) were generated by repeated stimulation with DCs and peptides. The single-cell TCR sequencing results of reactive T cells indicated that a single TCR clonotype dominated the paired TCRs. T cells engineered with this dominant TCR led to HLA-A*11:01-restricted recognition of the CT8314-22epitope, with higher avidity. Functional assays showed powerful cytotoxicity in vitro against the targets of several CT83-positive solid cancer cell lines. Furthermore, TCR-Ts showed therapeutic efficacy in three xenograft solid tumor models. The meta-analysis of gene expression of 92 CTAs indicated that most CTAs did not or at low levels in the thymus, which suggested that those CTAs may experience incomplete thymic central tolerance.ConclusionsHigh-avidity TCR against CT83 could be isolated from YHDs and efficiently mediate regression of well-established xenograft common solid tumors. The high-avidity TCR repertoire in the peripheral blood of some donors for CT83 and other CTAs provides the basis for the efficient isolation of high-avidity TCRs to target numerous solid cancers.
Your note, your way: how to write an inpatient progress note accurately and efficiently as an intern
Authors: Wei Miao , Salgado Efrain , Girard Christine E , Santoro Jonathan D , Lepore Natasha 
Published: July 2022

Abstract
A physician’s progress note is an essential piece of documentation regarding key events and the daily status of patients during their hospital stay. It serves not only as a communication tool between care team members, but also chronicles clinical status and pertinent updates to their medical care. Despite the importance of these documents, little literature exists on how to help residents to improve the quality of their daily progress notes. A narrative literature review of English language literature was performed and summated to provide recommendations on how to write an inpatient progress note more accurately and efficiently. In addition, the authors will also introduce a method to build a personal template with the goal of extracting relevant data automatically to reduce clicks for an inpatient progress note in the electronic medical record system.
Hippodrome: Data Race Repair Using Static Analysis Summaries
Authors: Costea Andreea , Tiwari Abhishek , Chianasta Sigmund , R Kishore , Roychoudhury Abhik , Sergey Ilya 
Published: July 2022

Implementing bug-free concurrent programs is a challenging task in modern software development. State-of-the-art static analyses find hundreds of concurrency bugs in production code, scaling to large codebases. Yet, fixing these bugs in constantly changing codebases represents a daunting effort for programmers, particularly because a fix in the concurrent code can introduce other bugs in a subtle way.In this work, we show how to harness compositional static analysis for concurrency bug detection, to enable a new Automated Program Repair (APR) technique for data races in large concurrent Java codebases. The key innovation of our work is an algorithm that translates procedure summaries inferred by the analysis tool for the purpose of bug reporting into small local patches that fix concurrency bugs (without introducing new ones). This synergy makes it possible to extend the virtues of compositional static concurrency analysis to APR, making our approacheffective(it can detect and fix many more bugs than existing tools for data race repair),scalable(it takes seconds to analyze and suggest fixes for sizeable codebases), andusable(generally, it does not require annotations from the users and can performcontinuousautomated repair). Our study, conducted on popular open-source projects, has confirmed that our tool automatically produces concurrency fixes similar to those proposed by the developers in the past.
Embolisasi Trans Arterial Pra Operasi pada Metastatic Bone Disease dari Renal Cell Carcinoma
Authors: Rizqi Putri , Setyawan Agung , Achmad  
Published: July 2022

Metastasis merupakan penyebaran kanker dari bagian tubuh utama saat kanker itu dimulai ke bagian lain dari tubuh tersebut. Sekitar sepertiga pasien dengan Renal cell carsinoma (RCC) memiliki metastasis tulang yang seringkali osteolitik dan menyebabkan morbiditas yang substansial, seperti nyeri, fraktur patologis, kompresi sumsum tulang belakang dan hiperkalsemia. Adanya metastasis tulang di RCC juga dikaitkan dengan prognosis yang buruk. Dalam makalah ini melaporkan satu presentasi kasus mengenai tindakan embolisasi pada pasien perempuan usia 25 tahun dengan diagnosa Fraktur patologis pada level vertebrae lumbal 1 due to Metastatic Bone Disease dari Process Renal Cell Carcinoma sebelum dilakukan operasi stabilisasi tulang belakang Embolisasi memiliki peran penting dalam mengobati metastasis tulang hipervaskuler. Embolisasi merupakan cara yang efektif untuk menangani kondisi hemoragik dan membatasi pasokan pendarahan untuk massa tumor, pada laporan kasus ini embolisasi pra operasi menurunkan pendarahan intra operasi menjadi 1150 ml. Embolisasi dapat dilakukan baik sebagai pengobatan definitif atau sebagai tambahan untuk manajemen bedah berikutnya.