bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Multicentre Study on the Prevalence of Respiratory Viruses in Children with Community Acquired Pneumonia Requiring Hospitalization in the Setting of the Zero-COVID Policy in China
Authors: Feng Ziheng , Xu Baoping , Zhong Lili , Chen Jing , Deng Jikui , Luo Zhengxiu , Cao Lingfeng , Tang Yu , Li Changchong , Jin Rong , Deng Li , Shang Yunxiao , Wu Ying , Zhao Hongwei , Feng Qianyu , Chen Xiangpeng , Xu Lili , Xie Zhengde 
Published: September 2022

Abstract
Stringent nonpharmaceutical interventions (NPIs) have been implemented worldwide to combat the COVID-19 pandemic, and the circulation and seasonality of common respiratory viruses have subsequently changed. Multicentre studies and comparisons of the prevalence of respiratory viruses accounting for community-acquired pneumonia (CAP) in hospitalized children between the pre-COVID period and the period after community and school reopening in the setting of the zero-COVID policy are rare. In this study, we included 1543 children with CAP who required hospitalization from November 1st, 2020 to April 30th, 2021 (Period 1) and 629 children with the same conditions from November 1st, 2018 to April 30th, 2019 (Period 2) in our study. All respiratory samples from the included patients were screened for six respiratory viruses (respiratory syncytial virus [RSV], adenovirus [ADV], influenza A virus [Flu A], influenza B virus [Flu B], parainfluenza virus type 1 [PIV1], and parainfluenza virus type 3 [PIV3]) using a multiplex real-time PCR assay. The median ages of enrolled patients at the time of diagnosis were 1.5 years and 1.0 years for period 1 and period 2, respectively. In period 1, viral pathogens were detected in 50.3% (776/1543) of enrolled patients. The most frequently identified viral pathogen was RSV (35.9%, 554/1543), followed by PIV3 (9.6%, 148/1543), PIV1 (3.6%, 56/1543), ADV (3.4%, 52/1543), Flu A (1.0%, 16/1543) and Flu B (0.8%, 13/1543). The total detection rates of these six viruses in the peak season of CAP were at the pre-COVID level. The prevalence of Flu A decreased dramatically and circulation activity was low compared to pre-COVID levels, while the incidence of PIV3 increased significantly. There were no significant differences in the detection rates of RSV, ADV, Flu B and PIV1 between the two periods. Our results showed that respiratory viruses accounted for CAP in hospitalized children at pre-COVID levels as communities and schools reopened within the zero-COVID policy, although the prevalence aetiology spectrum varied.
One pot synthesis of two potent Ag(I) complexes with quinoxaline ligand: X- ray structure, Hirshfeld analysis, antimicrobial, and antitumor investigations
Authors: elnaggar mostafa ahmed , Sharaf Mona Mohammed , Albering Jörg H. , Abu-Youssef Morsy A. M. , Kassem Taher S. , Soliman Saied M. , Badr Ahmed M. A. 
Published: September 2022

Abstract
In one pot, the self-assembly of Ag(I) nitrate and 2-chloroquinoxaline (2Cl-quinox) in water-ethanol mixture afforded two novel crystalline Ag(I) complexes. The major product is the polymeric complex [Ag(2Cl-quinox)(NO3)]n; (1) while the minor product (2) comprised two complex molecules which are the monomeric [Ag(2Cl-quinox)2(NO3)]; (2a) and polymeric [Ag(2Cl-quinox)(NO3)]n; (2b) complexes. The single crystal X-ray structure revealed that 1 and 2b are made up of two-dimensional infinite sheets. In contrast, 2a is a monomeric complex which has a highly distorted tetrahedral geometry around Ag(I) center. In all cases, the 2Cl-quinox molecule acts as a terminal monodentate ligand. Using Hirshfeld surface analysis, it is found that the complex units 1 and 2b not only have very similar molecular structures but also have almost similar crystal packing. The O...H hydrogen bonds and π-π stacking interactions contributed significantly to the molecular packing. Both complexes have broad-spectrum action towards multi drug-resistance (MDR) bacteria. The most effective function of 2 is against Proteus morganii with a MIC value of 8 µg/mL. Complex 2 (IC50 = 5.93 ± 0.52 𝜇g/mL) has remarkably greater cytotoxic effect towards lung carcinoma (A-549) than cis-platin (IC50 = 7.5 ± 0.69 𝜇g/mL) and AgNO3 (IC50 = 14.7 ± 0.53 𝜇g/mL). The cytotoxicity of complex 2 towards lung (A-549) and breast (MCF-7) cancer cell lines is greater than that of 1. This might be attributed to the higher content of silver in complex 2 than 1.
Correlation between nonalcoholic fatty liver disease and early left ventricular diastolic dysfunction in non-obese adults: a cross-sectional study
Authors: Cong Fangyuan , Zhu Luying , Deng Lihua , Xue Qian , Wang Jingtong 
Published: September 2022

Abstract
Background and aims
Non-alcoholic fatty liver disease (NAFLD) is associated with a greater risk of developing cardiovascular disease and have adverse impacts on the cardiac structure and function. Little is known about the effect of non-obese NAFLD upon cardiac function and structure. We aimed to compare the echocardiographic parameters reflecting the structures and functions of left ventricle (LV) between non-obese NAFLD group and control group, and explore the correlation of non-obese NAFLD with early LV diastolic dysfunction.
Methods and results
In this cross-sectional study, 316 non-obese inpatients were enrolled, including 72 participants with NAFLD (non-obese NAFLD group) and 244 participants without NAFLD (control group). LV structural and functional indices of two groups were comparatively analyzed. Early LV diastolic dysfunction was defined as the ratio of the peak velocity of the early filling (E) wave to the atrial contraction (A) wave <1. Compared with control group, the non-obese NAFLD group had the lower E/A〔(0.80±0.22) vs (0.88±0.35), X2=2.528, p =0.012〕and the smaller LV end-diastolic diameter〔(4.51±0.42)cm vs (4.64±0.43)cm, X2=2.182, p=0.030〕. Multivariate Logistic regression analysis showed that non-obese NAFLD was independently associated with an increased risk of early LV diastolic dysfunction〔OR=4.050，95%CI (1.452，11.296)，p=0.008〕.
Conclusions
Non-obese NAFLD was associated with an increased risk of early LV diastolic dysfunction, independent of well-identified cardiovascular risk factors.
Evaluation of urinary Binax Now for diagnosis of pneumococcal pneumonia in children
Authors: moustafa Sherif , Abdelhamid Nehal , Moustafa Nadia , Rifai Nihal El , Elkholy Amany , Kandil Manal 
Published: September 2022

Abstract
Purpose
Rapid diagnosis of pneumococcal pneumonia is challenging and current tools are limited by various factors. Comprehensive approach, which may increase accuracy of diagnosis and hence precise management is mandatory. The aim of the present study was to ascertain whether the urinary antigin test (Binax NOW) can add information and improve diagnostic yields when combined to conventional methods (ie, blood cultures, sputum cultures, molecular techniques).
Methods
This cross sectional study included 60 infants and children with pneumonia recruited from the pediatrics emergency room, inpatient departments and pediatric ICU. Thirty matched healthy control were enrolled. Cases were evaluated for the severity of community acquired pneumonia by CAP Severity of illness in children and PRESS score. The urinary antigin test( Binax NOW) ,induced sputum culture, blood culture ,PCR,CBC, CRP are tested simultaneously.
Results
Binax NOW was found of significance when compared to severity indices, the CRP levels and PCR values of the studied children(p-value < 0.001). The BinaxNow has sensitivity of 75% and specificity of 100%.
Conclusion
The urinary Binax NOW antigen test is a useful adjunct for rapid diagnosis of pneumococcus pneumonia with the potential to impact patient care and improve antibiotic stewardship.
Proton therapy &amp; oral mucositis in oral&amp;oropharyngeal cancers: outcomes, dosimetric&amp;NTCP benefit
Authors: Nangia Sapna , Gaikwad Utpal , MP Noufal , Sawant Mayur , Wakde Manoj , Mathew Ashwathy , Chilukuri Srinivas , Sharma Dayananda , Jalali Rakesh 
Published: September 2022

Abstract
Introduction – Radiation Induced oral mucositis (RIOM), is a common, debilitating, acute side effect of radiotherapy for oral cavity (OC) and oropharyngeal (OPx) cancers; technical innovations for reducing it are seldom discussed. Intensity modulated proton therapy (IMPT) has been reported extensively for treating OPx cancers,and less frequently for OC cancers. We aim to quantify the reduction in the likelihood of RIOM in treating these 2 subsites with IMPT compared to Helical Tomotherapy.
Material and methods – We report with acute toxicities and early outcomes of 22 consecutive patients of OC and OPx cancers treated with IMPT, and compare dosimetry and normal tissue complication probability (NTCP) of ≥ grade 3 mucositis for IMPT and HT.
Results – Twenty two patients, 77% males, 41% elderly and 73% OC subsite, were reviewed. With comparable target coverage, IMPT reduced mean dose and D32, D39, D45, D50 significantly, for both oral mucosa (OM) and spared oral mucosa (sOM). With IMPT, there was a 7% absolute and 16.5% relative reduction in NTCP for grade 3 mucositis for OM, compared to HT. IMPT further reduced NTCP for sOM and the benefit was maintained in OC, OPx subsites and elderly subgroup.
Acute toxicities, grade III dermatitis and mucositis, were noted in 50% and 45.5% patients, respectively, while 22.7% patients had grade 3 dysphagia. Compared with published data, hospital admission rate, median weight loss, feeding tube insertion, unplanned treatment gaps are less with IMPT. At median follow-up of 15 months, 81.8% are alive; 72.7%, alive without disease and 9%, alive with disease.
Conclusion: The dosimetric benefit of IMPT translates into NTCP reduction for Grade 3 mucositis compared to Helical Tomotherapy, for OPx and OC cancers and encourages the use of IMPT in their management.
Asymmetric Wigner Molecules in Nanowire Y-junctions
Authors: Mendez-Camacho Reyna , Cruz-Hernandez Esteban 
Published: September 2022

Abstract
The possibility of crystalline states of interacting electrons, known as Wigner crystals, has been intensively studied in each of the three dimensions. One-dimensional (1D) systems, however, can be interconnected forming two-dimensional (2D) lattices, being a three-terminal Y-junction (Y-J) the simplest one. Then, even when electrons in the individual branches of the Y are confined in 1D, as the Y-J is in 2D, one could expect significant differences in the crystalline state of the electron gas in a Y-J. With the recent report of fabrication of defect-free GaAs/AlGaAs Y-Js by epitaxial methods, the study of semiconductor Y-Js acquires a special relevance due to its eventual direct exploration. Here, by considering the collective electron interactions using a Yukawa-like effective potential, we explore a two-electron distribution in nanowire Y-Js by modulating its electron density via a screening parameter. We find that the electrons changes from a quasi-continuous to a Wigner molecule-like distribution when the electron density decreases in the Y-J. In bold contrast to the strict 1D case, where equidistant distributions of equal density are obtained in the Wigner regime, in the Y-J equidistant distributions of asymmetric density are induced. We also explore the effect of an external electric field acting along the Y-axis on the asymmetric distributions.
Racial disparities in overall survival after the introduction of cyclin-dependent kinase 4/6 inhibitors for patients with hormone receptor-positive, HER2 negative metastatic breast cancer
Authors: Alvarez Alvaro , Bernal Ana M. , Anampa Jesus 
Published: September 2022

Abstract
Purpose: CDK4/6i combined with endocrine therapy have improved HR+/HER2- metastatic breast cancer (MBC) outcomes. However, it is still unclear whether the response to CDK4/6i is similar for all races. Therefore, we aimed to assess overall survival (OS) trends stratified by race in patients with HR+/HER2- MBC after the approval of CDK4/6i, as part of the standard of care, in 2015.
Methods: We performed a population-based study using the SEER database. Patients with HR+/HER2- MBC were divided into two time-based cohorts: 1) 2011-2013, corresponding to the pre-CDK4/6i era, and 2) 2015-2017 to the post-CDK4/6i era. We used propensity score matching and identified 2,684 patients in each cohort that matched in several characteristics. Kaplan-Meier curves and Cox proportional hazard models were used to estimate 2-year OS. Additionally, we compared survival between groups with a stratified log-rank test. Lastly, we compared OS and breast cancer death risk between cohorts (stratified by race) using Fine and Gray model.
Results: The 2-year OS rate was 65% for the post-CDK4/6i group and 62% for the pre-CDK4/6i cohort (stratified log-rank p=0.025). The 2-year OS for NHW patients improved in the post-CDK4/6i era compared to the pre-CDK4/6i era (67% vs. 63%, p=0.033). However, OS did not improve for NHB (54% vs. 54%, p=0.876) or Hispanic (67% vs 65%, p=0.617) groups.
Conclusions: Our study confirms that outcomes for HR+/HER2- MBC have improved after CDK4/6i were introduced in 2015. However, this effect is primarily driven by the improved OS in NHW patients, without significant improvement in OS in NHB or Hispanics.
Mathematical Analysis of Convective Heat Exchanger from Renewable Sun’s Radiation through Nano-fluid in Direct Absorption Solar Collectors with the Procreation of Entropy.
Authors: Tafesse Girma , Daba Mitiku , G Naidu V 
Published: September 2022

Abstract
Now a days the high demand of energy cause the climate change which affect the living style of the people in the world. To mitigate this cases, the usage of renewable energy like solar energy plays a key role. In the application of thermal radiation, the work done is not 100% efficient due to the procreation of entropy. In this investigation, the researchers examined the heat and mass transfer from sun’s radiation through direct absorption into nanofluid with the creation of entropy. The mathematical governed partial differential equations are simplified by the use of similarity transformation variable which yields system of ordinary differential equations. To provide the solution for this problem, the wellknown analytic method called Homotopy Analysis Method implemented on Mathematica 12.1 based on the BVPh2.0 package. The validity of thisresult can be justified by comparing the solutions with different publishedarticles for specific values. From this study, we perceived that the transfer of heat from sun’s radiation is proliferated with multiple production of entropy. Thus, to gain the fruitful usage of renewable solar energy, weneed to maximize the heat transfer and minimize the creation of entropy. Keywords: Convective, Renewable Energy, DASC, Nanofluid, Entropy
Preparation of hydrogel based on poplar cellulose and its removal of Cd(II) from aqueous solution
Authors: Zhang Fengrong , Teng Jia , Han Dandan , Wu Lishun , Hou Wanguo 
Published: September 2022

Abstract

In this paper, poly aspartic acid/carboxymethyl poplar sawdust hydrogels (PASP/CMPP) and ascorbic acid/carboxymethyl poplar sawdust hydrogels (VC/CMPP) were prepared by aqueous polymerization using alkalized poplar sawdust (CMPP) as substrate and poly aspartic acid (PASP) and ascorbic acid (VC) as modifiers. PASP/CMPP and VC/CMPP samples were characterized by scanning electron microscope (SEM), Fourier transform infrared spectrometer (FT-IR) and surface area tester. The treatment effects of the two hydrogels on simulated wastewater containing cadmium were investigated by batch experiment. The results showed that PASP/CMPP had better adsorption effect than VC/CMPP under the same adsorption conditions. Interestingly, the solid concentration effect was found in the process of sorption kinetics and sorption isotherms. The sorption kinetics curves of Cd(II) on PASP/CMPP were well fitted by the quasi-second-order kinetic under different adsorbent concentrations. Langmuir and Freundlich sorption isotherm models were used to analyze the adsorption. The results showed that the adsorption conforms to Langmuir and Freundlich adsorption isotherm models. More importantly, PASP/CMPP composites are expected to be used as a new kind of environmental adsorbent for wastewater treatment.
Bombax Ceiba Flower Extract Induced Surface Groups on Se Nanoparticles to Enhance Antibacterial Activity and Urea Detection
Authors: Waqas Muhammad , Aslam Sidra , Akram Misbah , Khaliq Adnan , Ahsan Samreen , Liaqat Atif , Mirza Misbah , Safdar Muhammad , Qureshi Waseem Akhtar 
Published: September 2022

Abstract
Biosynthesis of metallic-nanomaterials has emerged as a non-toxic and economical approach to their applications in diverse fields especially in biomedical sciences. Herein, this study first time reporting the use of Bombax ceiba flower extract for synthesis of selenium nanoparticles (SeNPs). Initially, SeNPs were confirmed by turning the color of reaction mixtures from light yellow to red-brick. Scanning electron microscope (SEM) and Transmission electron microscopy (TEM) images showed spherical shaped nanoparticles with smooth surface, size ranges between 30–150 nm. Dynamic light scattering (DLS) showed 100–150 nm for the distribution of particle size. X-ray diffraction (XRD) analysis revealed SeNPs crystallinity and confirmed by matching with selenium JCPD card No. 06-362. Energy-dispersive X-ray (EDX) spectra showed presence of pure Se peaks that corroborate the conversion of selenium ions into its elemental form by bio-reduction. Fourier-transform infrared spectroscopy (FTIR) spectra demonstrated that involvement of -OH, C-H, C = C, and C = O functional groups for SeNPs formation. Raman Spectra peaks at 250 cm− 1 represent asymmetric trigonal selenium (t-Se). Ultraviolet-visible spectrophotometer (UV-Vis) peaks at 296 and 306 nm which is an indication of surface plasmon resonance (SPR). Moreover, maximum antibacterial activity of SeNPs were observed against Staphylococcus aureus- a gram positive bacteria that possess zone of inhibition (ZOI) 20 mm and Klebsiella pneumonia and Pseudomonas aeruginosa-gram negative bacterias with ZOI 28 mm, respectively, at concentration 100 µg/ ml. In addition, the surface functionalities induced through extract components adhere over Se binds with urea and give its detection up to 1mM in milk sample. Conclusively, synthesized SeNPs may act as a potent potential antibacterial pharmaceutical candidate.
Bioaccessibility and Caco-2 uptake of complex carotenoids profiles from Pitanga (Eugenia uniflora) and Buriti (Mauritia flexuosa) fruits
Authors: Berni Paulo , Negri Talita C. , Campoli Stephanie S. , Pereira Ericsem , Failla Mark L. , Canniatti-Brazaca Solange G. 
Published: September 2022

Abstract
Carotenoids are compounds from secondary metabolism of plants which have many essential health benefits for humans. Tropical fruits contain considerable amounts of carotenoids that have antioxidant, anti-inflammatory, provitamin A and anticancer actions, such as β-carotene and lycopene. The fate of complex carotenoid profiles from several fruit matrix still unknow. Pitanga and Buriti are very tasty, colorful and productive fruits from Brazilian biodiversity with potential to increment the nutrition of several populations. These fruits were analyzed for their carotenoid profiles, stability, bioaccessibility and uptake by in vitro digestion coupled to Caco-2 cells culture model. Complete profile of carotenoids were obtained by HPLC-DAD allowing to access detailed behavior of 14 carotenoids during the in vitro studies. Pitanga showed more complex profile of carotenes and xanthophylls than buriti which had higher concentration of total carotenes. Pitanga carotenoids are statistically less stable than buriti, while xanthophylls were less stable than carotenes. Violaxanthin, lutein and zeaxanthin from pitanga were significantly more bioaccessible than other carotenes excepting cis-γ-carotene. Similarly, in buriti, xanthophylls and γ-carotene forms were significantly more bioaccessible than the other carotenoids. The Caco-2 cells experiment showed that an important fraction of xanthophylls are absorbed in their esterified forms, despite β-carotene had the highest uptake. Pitanga presented higher cellular absorption of carotenoids than buriti. This work evidence the essential need to better understand the bioaccessibility of carotenoids in diverse plant food matrix.
A novel lncRNA BF368575 promotes cell proliferation in hepatocellular carcinoma via PI3K/AKT/mTOR signaling pathway
Authors: zeng xiaohui , Liu Chang , He Qingjun , Zou Zhaowei , Liao Quanxing , Wu Cheng , Li Guanger , Zhang Zezhong , Tian Yun , Zhu Siyu , Yang Xianzi , Cui Shuzhong , Zeng Lisi 
Published: September 2022

Abstract
Purpose
LncRNA-BF368575 is a novel long non-coding RNA, its biological function in hepatocellular carcinoma (HCC) remains unknown.
Methods
The expression levels of lncRNA-BF368575 in HCC tissues and cell lines were evaluated by reverse transcription-quantitative polymerase chain reaction (RT-qPCR). In situ hybridization (ISH) was performed to determine the expression of lncRNA-BF368575 in a tissue chip containing 89 paired HCC and para-cancerous tissues. Fractionation of nuclear and cytoplasmic RNA was performed to determine the subcellular localization of lncRNA-BF368575. Cell viability and colony-forming ability were determined by cell counting kit-8 (CCK-8) assay and colony formation assay. Tumor growth in vivo was detected using the xenograft model. The molecular mechanisms of lncRNA-BF368575 were investigated using Western blotting and RNA-Binding Protein Immunoprecipitation (RIP).
Results
The results showed that lncRNA-BF368575 was increased in most HCC tissues and cell lines. Moreover, the lower lncRNA-BF368575 expression level is a favorable prognostic factor in disease-free survival (DFS). LncRNA-BF368575 is mostly localized in the cytoplasm. In vitro and in vivo experiments showed that downregulation of lncRNA-BF368575 suppressed cell proliferation and colony-forming activity, yet overexpression of lncRNA-BF368575 leads to an opposite result. Furthermore, lncRNA-BF368575 activates the PI3K/AKT/mTOR signaling pathway by increasing the expression of p-PI3K(Tyr607), p-AKT(Thr308), p-mTOR(Ser2448), p-4E-BP1(Thr37/46), p-S6(Ser235/236). LY294002 could reverse the biological functions of lncRNA-BF368575. RIP shows that LncRNA-BF368575 could bind to p-mTOR(Ser2448), p-AKT(Thr308), and p-4E-BP1(Thr37/46).
Conclusion
Our study demonstrates that lncRNA-BF368575 enhances HCC proliferation and growth both in vitro and vivo via activating the PI3K/AKT/mTOR signaling pathway, which implicates that our findings may provide a potential target for HCC treatments.