bluuebunny/crossref_metadata_2025_split huggingface dataset:
Understanding Practices Through an Inclusive Philosophy of Experiencing: Insights from Four Art Museums
Authors: Jevnaker Birgit Helene , Olaisen Johan 
Published: July 2022

AbstractThe chapter discusses the inclusive knowledge philosophy fundamental for different modes of experiencing living enterprises. We combine two related philosophical lenses to enable fundamental understanding of concerted practices and strategic accomplishments for leadership and management. The American pragmatist philosopher John Dewey pointed to the importance of restoring the continuity between the refined and intensified experiences in our practices and everyday doings. He based this restoring on “the inclusive philosophic idea”. By this idea he was acknowledging the possibilities of imagination and associations among the social, technological-physical, natural, and mental modes. Another philosopher, the Norwegian Arne Naess, also highlighted imaginative experience and the human/nature interconnectedness including its potential joy and perseverance for individuals as well as organizations. We provide examples drawing on our own studies of four art museums. Given that rich knowledge endeavours are necessary to develop arts for society, how can valuable exhibition practices be accomplished in inclusive, resourceful ways? The chapter introduces a philosophical framework for how this might work. Dynamic art, design, and innovation processes are imaginative practices where the past, the present, and the future melt together. The imaginative experiencing in each museum place might be crucial not only for its recurrent co-creation but also for the make-believe of sustainable arts thinking.
Epigenomics of conventional type-I dendritic cells depicted preferential control of TLR9 versus TLR3 response by NCoR1 through differential IRF3 activation
Authors: Mishra Gyan Prakash , Jha Atimukta , Ahad Abdul , Sen Kaushik , Sen Aishwarya , Podder Sreeparna , Prusty Subhasish , Biswas Viplov Kumar , Gupta Bhawna , Raghav Sunil Kumar 
Published: July 2022

AbstractTight control of gene regulation in dendritic cells (DCs) is important to mount pathogen specific immune responses. Apart from transcription factor binding, dynamic regulation of enhancer activity through global transcriptional repressors like Nuclear Receptor Co-repressor 1 (NCoR1) plays a major role in fine-tuning of DC responses. However, how NCoR1 regulates enhancer activity and gene expression in individual or multiple Toll-like receptor (TLR) activation in DCs is largely unknown. In this study, we did a comprehensive epigenomic analysis of murine conventional type-I DCs (cDC1) across different TLR ligation conditions. We profiled gene expression changes along with H3K27ac active enhancers and NCoR1 binding in the TLR9, TLR3 and combined TLR9 + TLR3 activated cDC1. We observed spatio-temporal activity of TLR9 and TLR3 specific enhancers regulating signal specific target genes. Interestingly, we found that NCoR1 differentially controls the TLR9 and TLR3-specific responses. NCoR1 depletion specifically enhanced TLR9 responses as evident from increased enhancer activity as well as TLR9-specific gene expression, whereas TLR3-mediated antiviral response genes were negatively regulated. We validated that NCoR1 KD cDC1 showed significantly decreased TLR3 specific antiviral responses through decreased IRF3 activation. In addition, decreased IRF3 binding was observed at selected ISGs leading to their decreased expression upon NCoR1 depletion. Consequently, the NCoR1 depleted cDC1 showed reduced Sendai Virus (SeV) clearance and cytotoxic potential of CD8+ T cells upon TLR3 activation. NCoR1 directly controls the majority of these TLR specific enhancer activity and the gene expression. Overall, for the first time, we revealed NCoR1 mediates transcriptional control towards TLR9 as compared to TLR3 in cDC1.
Graphical abstract
The rate of venous thromboembolism after knee bone marrow concentrate procedures: should we anticoagulate?
Authors: Centeno Christopher J. , Money Brandon T. , Dodson Ehren , Stemper Ian , Steinmetz Neven J. 
Published: July 2022

Abstract
Purpose
Intra-articular injections of autologous, minimally manipulated, cell therapies such as bone marrow concentrate (BMC) to treat knee osteoarthritis (OA) may delay or prevent future total knee arthroplasty (TKA). Arthroplasty has the known and substantial risk of venous thromboembolism (VTE) and requires routine prophylaxis, whereas the VTE risk associated with knee BMC injections is unknown. We report on the rate of VTE from a large orthobiologics patient registry and assess whether knee BMC procedures require routine prophylaxis.

Methods
A retrospective analysis of knee osteoarthritis cases tracked in a treatment registry and treated at 72 clinical sites with BMC from 2007 to 2020 who were not prophylactically anticoagulated was performed to identify adverse events (AEs) associated with VTE. Treating physicians were contacted to improve discovery of possible occurrences of VTE.

Results
Twenty cases (0.16%) of VTE were identified from the registry of 12,780 knee BMC treatments. These events were less frequent than the published data demonstrate for anticoagulated TKA patients.

Conclusion
Based on the rates of VTE from our retrospective treatment registry analysis compared to the risk of medication-induced haemorrhage, routine prophylactic anticoagulation is not recommended for intra-articular knee BMC procedures. Further research into safety and efficacy of BMC treatment for knee OA is warranted.

Clinical trial identifier
NCT03011398, retrospectively registered.
Synthesis, characterization, and biological activities of new conjugates of Guanosine grafted on polyvinyl alcohol, carbohydrate chitosan, and cellulose
Authors: El-Naggar Sabry A. , El-Barbary Ahmed A. , Hafez Yehia A. , Salama Wesam M. , Elkholy Hazem M. , Shaker Mohamed 
Published: July 2022

AbstractGuanosine (GU) is a purine nucleoside that has different biological applications. This study aimed to synthesize, characterize, and enhance the biological activities of GU through its covalently grafting on polyvinyl alcohol (PVA), chitosan (CS), and cellulose (CL). In this regard, the conjugation was constructed by different linkers such as chloroacetyl chloride, 2-bromopropionyl bromide, and epichlorohydrin (EPCH). The resulted novel conjugates were characterized by FT-IR, 1H-NMR, GPC, and TGA techniques. FT-IR spectra revealed the main characteristic groups, O–H, N–H, C=O and C=N of GU moieties. Furthermore, 1H-NMR spectra showed the aromatic C–H, O–H, and N–H protons of the grafted GU moieties. Two decomposition stages of grated polymers with high thermal stability are illustrated by TGA. GU showed no antifungal activity against Aspergillus fumigatus and Candida albicans. However, its conjugates: P-1A, P-1B, P-2A, P-2B, P-3A, and P-3B displayed significant antifungal effect with inhibitory zones in the range 8–11 mm. As compared to GU group, most of GU-polymer conjugates showed significant in vivo antitumor activity against EAC-bearing mice via the reduction in total tumor volume. In summary, these conjugates are biologically active macromolecules and may act as candidate carrier systems for other applications such as drug delivery.
Muscle quality indices separately associate with joint-level power-related measures of the knee extensors in older males
Authors: Hirata Kosuke , Ito Mari , Nomura Yuta , Kawashima Chiho , Tsuchiya Yuma , Ooba Kosuke , Yoshida Tsukasa , Yamada Yosuke , Power Geoffrey A. , Tillin Neale A. , Akagi Ryota 
Published: July 2022

Abstract
Purpose
The purpose of this study was to investigate associations of muscle quality indices with joint-level power-related measures in the knee extensors of thirty-two older males (65–88 years).

Methods
Muscle quality indices included: echo intensity, ratio of intracellular- to total water content (ICW/TW), and specific muscle strength. Echo intensity was acquired from the rectus femoris (EIRF) and vastus lateralis (EIVL) by ultrasonography. ICW/TW was computed from electrical resistance of the right thigh obtained by bioelectrical impedance spectroscopy. Specific muscle strength was determined as the normalized maximal voluntary isometric knee extension (MVIC) torque to estimated knee extensor volume. Isotonic maximal effort knee extensions with a load set to 20% MVIC torque were performed to obtain the knee extension power-related measures (peak power, rate of power development [RPD], and rate of velocity development [RVD]). Power and RPD were normalized to MVIC.

Results
There were no significant correlations between muscle quality indices except between EIRF and EIVL (|r|≤ 0.253, P ≥ 0.162). EIRF was negatively correlated with normalized RPD and RVD (r ≤  − 0.361, P ≤ 0.050). ICW/TW was positively correlated with normalized peak power (r = 0.421, P = 0.020). Specific muscle strength was positively correlated with absolute peak power and RPD (r ≥ 0.452, P ≤ 0.012).

Conclusion
Knee extension power-related measures were lower in participants with higher EI, lower ICW/TW, and lower specific muscle strength, but the muscle quality indices may be determined by independent physiological characteristics.
Bladed and bladeless conical trocars do not differ in terms of caused fascial defect size in a Porcine Model
Authors: Paasch Christoph , Mantke Anne , Hunger Richard , Mantke Rene 
Published: July 2022

Abstract
Introduction
Trocar insertion during laparoscopy may lead to complications such as bleeding, bowel puncture and fascial defects with subsequent trocar site hernias. It is under discussion whether there is a difference in the extent of the trauma and thus in the size of the fascia defect between blunt and sharp trocars. But the level of evidence is low. Hence, we performed a Porcine Model.

Methods
A total of five euthanized female pigs were operated on. The average weight of the animals was 37.85 (Standard deviation SD 1.68) kg. All pigs were aged 90 ± 5 days. In alternating order five different conical 12-mm trocars (3 × bladeless, 2 × bladed) on each side 4 cm lateral of the mammary ridge were placed. One surgeon performed the insertions after conducting a pneumoperitoneum with 12 mmHg using a Verres’ needle. The trocars were removed after 60 min. Subsequently, photo imaging took place. Using the GSA Image Analyser (v3.9.6) the respective abdominal wall defect size was measured.

Results
The mean fascial defect size was 58.3 (SD 20.2) mm2. Bladed and bladeless trocars did not significant differ in terms of caused fascial defect size [bladed, 56.6 (SD 20) mm2 vs. bladeless, 59.5 (SD 20.6) mm2, p = 0.7]. Without significance the insertion of bladeless trocars led to the largest (Kii Fios™ First entry, APPLIEDMEDICAL©, 69.3 mm2) and smallest defect size (VersaOne™ (COVIDIEN©, 54.1 mm2).

Conclusion
Bladed and bladeless conical 12-mm trocars do not differ in terms of caused fascial defect size in the Porcine Model at hand. The occurrence of a trocar site hernia might be largely independent from trocar design.
Prognostic value of left atrial volume index in degenerative mitral stenosis
Authors: Yedidya Idit , Butcher Steele C. , Stassen Jan , van der Bijl Pieter , Ngiam Jinghao Nicholas , Chew Nicholas W. S. , Sia Ching-Hui , Leow Ryan , Li Tony Yi-Wei , Kong William K. F. , Poh Kian Keong , Kornowski Ran , Marsan Nina Ajmone , Delgado Victoria , Bax Jeroen J. 
Published: July 2022

Abstract
Purpose
Degenerative mitral stenosis (DMS) is associated with a poor prognosis. Although mean transmitral gradient (TMG) has shown a good correlation with outcome, little is known about the association between other echocardiographic parameters and prognosis in patients with DMS. The current study aimed to evaluate the prognostic value of left atrial volume index (LAVI) in patients with DMS.

Methods
A total of 155 patients with DMS (72[63–80] years, 67% female) were included. The population was divided according to LAVI: normal-sized LAVI (LAVI ≤ 34 ml/m2); and enlarged LAVI (> 34 ml/m2).

Results
Patients with enlarged LAVI had a higher left ventricular mass index (120[96–146] vs. 91[70–112] g/m2 p < 0.001), as well as a higher prevalence of significant mitral regurgitation and severe aortic stenosis (23% vs. 10% p = 0.046 and 38% vs. 15% p=0.001, respectively) compared to patients with normal-sized LAVI. During a median follow-up of 25 months, 56 (36%) patients died. Patients with enlarged LAVI had worse prognosis compared to patients with normal-sized LAVI (p = 0.026). In multivariable Cox regression model, an enlarged LAVI was independently associated with all-cause mortality (HR 2.009, 95% CI 1.040 to 3.880, P = 0.038).

Conclusion
An enlarged LAVI (> 34 ml/m2) is significantly associated with excess mortality in patients with DMS. After adjusting for potential confounders, an enlarged LAVI was the only parameter that remained independently associated with prognosis.
Stability analysis and control technology of gob-side entry retaining with double roadways by filling with high-water material in gently inclined coal seam
Authors: Xie Shengrong , Wang En , Chen Dongdong , Li Hui , Jiang Zaisheng , Yang Hongzeng 
Published: July 2022

AbstractTo ameliorate the defects of insufficient support resistance of traditional roadside filling bodies for gob-side entry retaining (GER), overcome the inability to adapt to the deformation of surrounding rock, and isolate the goaf effectively, a new type of high-water material as a roadside filling body for GER technology with double roadways was proposed. The instability analysis and control technology of GER with double roadways by filling high-water material into a gently inclined coal seam were studied. The basic mechanical properties of the new high-water material were investigated through laboratory experiments, and their main advantages were identified. The reasonable width of the roadside filling wall of a high-water material was obtained by combining ground pressure observation and theoretical calculations. The distribution characteristics of the stress and plastic zone of surrounding rock of GER after being stabilized by the disturbance of the working face were studied using numerical simulations, and the failure range of GER by filling with high-water material was revealed. Based on this, a coupling control technology of anchor cables and bolts + single props + metal mesh + anchor bolts is proposed. Through the coupling methods of arranging borehole peeping and observing the convergences of surrounding rock, the results demonstrate that GER with double roadways by filling with a 1.8-m-wide high-water material has a good control effect. The above research will play an active role in promoting the application of high-water materials in GER roadside filling.
Measurement of heat flow through vacuum insulating glass part 1: measurement area in direct thermal contact with specimen
Authors: Kocer Cenk , Aronen Antti , Collins Richard , Asano Osamu , Ogiso Yumi 
Published: July 2022

AbstractNon-uniformities in the heat flow through the support pillars in vacuum insulating glass (VIG) can lead to significant errors in the measurement of the thermal insulating properties of these devices. This paper discusses these errors in instruments for which the measurement area is in direct thermal contact with the glass sheets. The spatial non-uniformities of the heat flow in different VIG designs are modelled using the finite element method. For measuring areas with large dimension compared with the separation of the support pillars, the errors are unacceptably large for all practical designs of VIG when using guarded hot plate instruments. These errors are less for heat flow meter instruments due to the construction of the heat flux transducer.
Mercator's Geometric Method in the Construction of His Projection from 1569
Authors: Pápay Gyula 
Published: July 2022

AbstractThe geometric method Mercator used to construct his projection from 1569 was reconstructed. Modern mathematical means are required for the computational creation of Mercator’s projection. It could be proven that Mercator worked out his projection exclusively with compass and linear. The methodological principles established by Ptolemy were used and further developed by Mercator. However, he did not describe his method and so an enigma of Mercator projection emerged.
Understanding the Mott insulating state in 1T-TaS2 and 1T-TaSe2
Authors: Fei Ying , Wu Zongxiu , Zhang Wenhao , Yin Yi 
Published: July 2022

AbstractIn this article, we review the recent progress of the scanning tunneling microscopy studies of 1T-TaS2 and 1T-TaSe2 for bulk single crystals and molecular beam epitaxy monolayer films. We focus on how to understand the Mott insulating state in the whole set of materials, even when the stacking order takes effect. Based on this understanding, we discuss tuning the Mott insulator to a metallic state with different techniques, with Mott physics information revealed from the tuning process. The Kondo physics and quantum spin liquid state of 1T-TaS2 and 1T-TaSe2 are further discussed. This good platform of strong correlation must bring more intriguing phenomenon and physics in the future.
Climate Extremes are Becoming More Frequent, Co-occurring, and Persistent in Europe
Authors: Pradhan Prajal , Seydewitz Tobias , Zhou Bin , Lüdeke Matthias K. B. , Kropp Juergen P. 
Published: July 2022

AbstractWith global warming, many climate extremes are becoming more frequent, often co-occurring, or repeatedly occurring in consecutive years. However, only limited studies have investigated these changes of climate extremes together. We study these changes in Europe for the last seven decades (1950–2019) based on 39 climate indices to identify climate extreme hotspots and coldspots. These indices belong to the four climate index groups: cold, heat, drought, and precipitation. Compared to the first half of the study period (1950–1984), most of our study locations faced heat extremes that are more frequent and occurring in consecutive years in the second half (1985–2019). However, the number of cold extremes has decreased in most locations. Simultaneously, some locations, mainly the Mediterranean region, faced an increase in droughts while others, e.g., parts of Eastern Europe and Northern Europe, experienced more intense precipitation. Two or more of these cold, heat, drought, and precipitation extremes have also co-occurred in a few locations of our study area in the same year. Our study highlights that climate extremes are becoming more frequent, co-occurrent, and persistent in Europe. These changes in climate extremes are associated with climate change. Therefore, we could infer that climate change mitigation is crucial for limiting these extremes.
The MeerTime Pulsar Timing Array: A census of emission properties and timing potential
Authors: Spiewak R. , Bailes M. , Miles M. T. , Parthasarathy A. , Reardon D. J. , Shamohammadi M. , Shannon R. M. , Bhat N. D. R. , Buchner S. , Cameron A. D. , Camilo F. , Geyer M. , Johnston S. , Karastergiou A. , Keith M. , Kramer M. , Serylak M. , van Straten W. , Theureau G. , Venkatraman Krishnan V. 
Published: July 2022

AbstractMeerTime is a five-year Large Survey Project to time pulsars with MeerKAT, the 64-dish South African precursor to the Square Kilometre Array. The science goals for the programme include timing millisecond pulsar (MSPs) to high precision (${<} 1 \unicode{x03BC} \mathrm{s}$) to study the Galactic MSP population and to contribute to global efforts to detect nanohertz gravitational waves with the International Pulsar Timing Array (IPTA). In order to plan for the remainder of the programme and to use the allocated time most efficiently, we have conducted an initial census with the MeerKAT ‘L-band’ receiver of 189 MSPs visible to MeerKAT and here present their dispersion measures, polarisation profiles, polarisation fractions, rotation measures, flux density measurements, spectral indices, and timing potential. As all of these observations are taken with the same instrument (which uses coherent dedispersion, interferometric polarisation calibration techniques, and a uniform flux scale), they present an excellent resource for population studies. We used wideband pulse portraits as timing standards for each MSP and demonstrated that the MeerTime Pulsar Timing Array (MPTA) can already contribute significantly to the IPTA as it currently achieves better than$1\,\unicode{x03BC}\mathrm{s}$timing accuracy on 89 MSPs (observed with fortnightly cadence). By the conclusion of the initial five-year MeerTime programme in 2024 July, the MPTA will be extremely significant in global efforts to detect the gravitational wave background with a contribution to the detection statistic comparable to other long-standing timing programmes.
Product Market Competition and FDI Decisions
Authors: Loncan Tiago 
Published: July 2022

AbstractI examine whether competition from domestic industry rivals affects firms’ proclivity to undertake foreign direct investment (FDI) and their country location choices. I find that competition affects foreign production decisions and the geography of international investments. While firms enduring stiffer competition are significantly less likely to undertake FDI, this effect is heterogeneous across firms. Competition deters FDI more strongly when costs are heavier, whereas it has weaker effects when efficiency is higher, growth opportunities are valuable, and cash reserves are higher. FDI location models suggest that when going abroad, firms facing stronger competition are more likely to pursue economies of productivity and taxation.
Does Finance Make Us Less Social?
Authors: Cronqvist Henrik , Warachka Mitch , Yu Frank 
Published: July 2022

AbstractInformal risk sharing within social networks and formal financial contracts both enable households to manage risk. We find that financial contracting reduces participation in social networks. Specifically, increased crop insurance usage decreased local religious adherence and congregation membership in agricultural communities. Our identification utilizes the Federal Crop Insurance Reform Act of 1994 that doubled crop insurance usage nationally within a year, although changes in usage varied across counties. Difference-in-difference and Spatial First Difference tests confirm that households substituted insurance for religiosity. This substitution was associated with reductions in crop diversification and crop yields, indicating an increase in moral hazard.
The Opening Dilemma: Why Democracies Cannot Found Themselves
Authors: Bensel Richard 
Published: July 2022

AbstractDemocratic states often claim that their authority rests upon the “will of the people” as expressed through representative institutions. However, there is an irresolvable conundrum that undermines that claim: the “opening dilemma” that invariably attends the founding of democratic states during which those representative institutions are created. While familiar to democratic theorists, the “opening dilemma” has many hitherto unexplored dimensions, among them its actual occurrence in democratic politics. Using the 1869 Illinois Constitutional Convention as a case study, the article demonstrates why individual preferences cannot effect a founding without the intervention of arbitrary and thus undemocratic authority. The conclusion suggests why the opening dilemma might become a serious threat to American democracy if the nation were to attempt to convene a new constitutional convention.