bluuebunny/crossref_metadata_2025_split huggingface dataset:
The paradox of the artificial intelligence system development process: the use case of corporate wellness programs using smart wearables
Authors: Angelucci Alessandra , Li Ziyue , Stoimenova Niya , Canali Stefano 
Published: September 2022

AbstractArtificial intelligence (AI) systems have been widely applied to various contexts, including high-stake decision processes in healthcare, banking, and judicial systems. Some developed AI models fail to offer a fair output for specific minority groups, sparking comprehensive discussions about AI fairness. We argue that the development of AI systems is marked by a central paradox: the less participation one stakeholder has within the AI system’s life cycle, the more influence they have over the way the system will function. This means that the impact on the fairness of the system is in the hands of those who are less impacted by it. However, most of the existing works ignore how different aspects of AI fairness are dynamically and adaptively affected by different stages of AI system development. To this end, we present a use case to discuss fairness in the development of corporate wellness programs using smart wearables and AI algorithms to analyze data. The four key stakeholders throughout this type of AI system development process are presented. These stakeholders are called service designer, algorithm designer, system deployer, and end-user. We identify three core aspects of AI fairness, namely, contextual fairness, model fairness, and device fairness. We propose a relative contribution of the four stakeholders to the three aspects of fairness. Furthermore, we propose the boundaries and interactions between the four roles, from which we make our conclusion about the possible unfairness in such an AI developing process.
No difference in sports participation and patient-reported functional outcomes between total knee arthroplasty and unicompartmental knee arthroplasty at minimum 2-year follow-up in a matched control study
Authors: Meena Amit , Abermann Elisabeth , Hoser Christian , Farinelli Luca , Hepperger Caroline , Raj Akshya , Patralekh Mohit Kumar , Fink Christian 
Published: September 2022

Abstract
Purpose
The purpose of this study was to compare (1) sports participation and type of sports activity between TKA and UKA patients; (2) functional outcome and activity level between TKA and UKA; and (3) survivorship of the prosthesis in both the groups.

Methods
Prospectively collected data were obtained from an arthroplasty database to identify patients who underwent primary TKA and UKA. Both the cohorts of TKA and UKA were matched, controlling for age, sex, BMI and preoperative patient-reported outcomes, which include Oxford Knee Score (OKS), Tegner activity level, and visual analog scale (VAS) for pain score. After matching the two groups, 287 TKA and 69 UKA cases were available to be included in the study. Patients were evaluated pre- and postoperatively at 2 years for sports participation and sports preference, patient-reported outcomes, activity levels, and improvement in knee pain.

Results
The mean age of the TKA and UKA groups were 75.7 ± 8.1 and 74.2 ± 8.8, respectively. There was no significant difference between the two groups concerning the demographic variables. Significant improvement was noted in the weekly sports participation at the final follow-up compared to preoperative sports participation in both the TKA and UKA groups (p < 0.05). All patients were able to return to their desired sporting activity. No significant difference was noted between the two groups in sports participation preoperatively and postoperatively (p > 0.05). OKS, Tegner activity level and VAS for pain demonstrated a significant improvement from preoperative to 2 years postoperatively (p < 0.05). However, preoperative and postoperative patient-reported outcomes did not differ significantly between the TKA and UKA groups (p > 0.05). No case of revision surgery was found at a 2-year follow-up in both groups.

Conclusion
Traditionally, in isolated medial compartment osteoarthritis, UKA has been considered to be the procedure with better functional outcomes, but the current study demonstrates that when confounding factors are controlled, both TKA and UKA are effective, and offer similar functional outcomes and result in similar improvement in sports participation. These findings will be helpful to counsel the patients to choose the best suitable operative procedure between UKA and TKA.

Level of evidence
Level 3.
Characterization of the exopolymer-producing Pseudoalteromonas sp. S8-8 from Antarctic sediment
Authors: Rizzo Carmen , Perrin Elena , Poli Annarita , Finore Ilaria , Fani Renato , Lo Giudice Angelina 
Published: September 2022

Abstract
A synergistic approach using cultivation methods, chemical, and bioinformatic analyses was applied to explore the potential of Pseudoalteromonas sp. S8-8 in the production of extracellular polymeric substances (EPSs) and the possible physiological traits related to heavy metal and/or antibiotic resistance. The effects of different parameters (carbon source, carbon source concentration, temperature, pH and NaCl supplement) were tested to ensure the optimization of growth conditions for EPS production by the strain S8-8. The highest yield of EPS was obtained during growth in culture medium supplemented with glucose (final concentration 2%) and NaCl (final concentration 3%), at 15 °C and pH 7. The EPS was mainly composed of carbohydrates (35%), followed by proteins and uronic acids (2.5 and 2.77%, respectively) and showed a monosaccharidic composition of glucose: mannose: galactosamine: galactose in the relative molar proportions of 1:0.7:0.5:0.4, as showed by the HPAE-PAD analysis. The detection of specific molecular groups (sulfates and uronic acid content) supported the interesting properties of EPSs, i.e. the emulsifying and cryoprotective action, heavy metal chelation, with interesting implication in bioremediation and biomedical fields. The analysis of the genome allowed to identify a cluster of genes involved in cellulose biosynthesis, and two additional gene clusters putatively involved in EPS biosynthesis.

Key points
• A cold-adapted Pseudoalteromonas strain was investigated for EPS production.
• The EPS showed emulsifying, cryoprotective, and heavy metal chelation functions.
• Three gene clusters putatively involved in EPS biosynthesis were evidenced by genomic insights.
Tuberous Breast, Deformities, and Asymmetries: A Retrospective Analysis Comparing Fat Grafting Versus Mastopexy and Breast Implants
Authors: Gentile Pietro 
Published: September 2022

Abstract
Background
The tuberous breast is considered a breast deformity characterized by varying degrees of herniation of the parenchyma, widened nipple-areolar complex (NAC), absence of the lower quadrants, and may involve several degrees of hypoplasia and asymmetry causing significant psychosocial distress.

Objectives
The paper aimed to compare the results obtained in patients suffering tuberous breast treated with fat grafting (FG), with those of patients treated with a mastopexy and silicone implants (M-SI) also analyzing the influence of breast and chest deformities (degrees of hypoplasia and tuberous breast, volume and NAC asymmetry, pectus excavatum, and carinatum) in the reconstructive outcomes.

Methods
A retrospective, case-control study was conducted. Thirty-five patients affected by tuberous breast with several degrees of hypoplasia and asymmetry were treated with FG, comparing results with those of 30 patients treated with M-SI. Postoperative follow-up took place at 1, 3, 7, 12, 24, 48, weeks, and then annually for 2 years.

Results
77% (n = 27) of patients treated with two FG procedures showed excellent results after 1 year compared with the patients treated with only one M-SI procedure, who showed the same results in 73% (n = 22) of cases, but the naturalness and the satisfaction degree in the FG group were higher than that in the M-SI group (p < .0001 vs. M-SI group).

Conclusions
Patients treated with FG showed natural breasts without scars and excellent cosmetic results after two procedures. Patients treated with M-SI showed more evident and lasting results after only one procedure, presenting though scars and less natural results.

Level of Evidence IV
This journal requires that authors assign a level of evidence to each article. For a full description of these evidence-based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266
Tackling the Science Usability Gap in a Warming World: Co-Producing Useable Climate Information for Natural Resource Management
Authors: Cross Molly S. , Oakes Lauren E. , Kretser Heidi E. , Bredehoft Raymond , Dey Paul , Mahoney Anika , Smith Noelle , Tator Ian , Wasseen Jim 
Published: September 2022

AbstractDeveloping scientific information that is used in policy and practice has been a longstanding challenge in many sectors and disciplines, including climate change adaptation for natural resource management. One approach to address this problem encourages scientists and decision-makers to co-produce usable information collaboratively. Researchers have proposed general principles for climate science co-production, yet few studies have applied and evaluated these principles in practice. In this study, climate change researchers and natural resource managers co-produced climate-related knowledge that was directly relevant for on-going habitat management planning. We documented our methods and assessed how and to what extent the process led to the near-term use of co-produced information, while also identifying salient information needs for future research. The co-production process resulted in: 1) an updated natural resource management plan that substantially differed from the former plan in how it addressed climate change, 2) increased understanding of climate change, its impacts, and management responses among agency staff, and 3) a prioritized list of climate-related information needs that would be useful for management decision-making. We found that having a boundary spanner—an intermediary with relevant science and management expertise that enables exchange between knowledge producers and users—guide the co-production process was critical to achieving outcomes. Central to the boundary spanner’s role were a range of characteristics and skills, such as knowledge of relevant science, familiarity with management issues, comfort translating science into practice, and an ability to facilitate climate-informed planning. By describing specific co-production methods and evaluating their effectiveness, we offer recommendations for others looking to co-produce climate change information to use in natural resource management planning and implementation.
Environmental Chemicals and their Association with Hyperparathyroidism
Authors: McMullin Jessica Liu , Codner Jesse , Patel Snehal G. , Sharma Jyotirmay , Hu Xin , Jones Dean P. , Weber Collin J. , Saunders Neil D. 
Published: September 2022

AbstractBackgroundThe incidence of hyperparathyroidism has increased in the USA. The previous work from our institution detected environmental chemicals (EC) within hyperplastic parathyroid tumors. The National Health and Nutrition Examination Survey (NHANES) is a program designed to assess the health status of people in the USA and includes measurements of EC in serum. Our aim was to determine which EC are associated with elevated parathyroid hormone (PTH) and calcium levels within NHANES.MethodsNHANES was queried from 2003–2016 for our analysis with calcium. A separate subgroup was queried from 2003–2006 that included PTH levels. Subjects with elevated calcium, and elevated PTH and normal Vitamin D levels were identified. Wilcoxon rank sum tests were used to analyze levels of EC in those with elevated calcium, and those with elevated PTH in the subgroup. All EC with p < 0.05 were then included in separate multivariate models adjusting for serum vitamin D and creatinine for PTH and albumin for calcium.ResultsThere were 51,395 subjects analyzed, and calcium was elevated in 2.1% (1080) of subjects. Our subgroup analysis analyzed 14,681 subjects, and PTH was elevated without deficient Vitamin D in 9.4% (1,377). Twenty‐nine different polychlorinated biphenyls and the organochlorine pesticides hexachlorobenzene, transnonachlor, oxychlordane, and p,p’‐dichlorodiphenyldichloroethylene (DDE) were found to be associated with elevated calcium and separately with elevated PTH (all p < 0.05).ConclusionIn NHANES, 33 ECs were found to be associated with elevated calcium as well as elevated PTH levels on our subgroup analysis. These chemicals may lead us toward a causal link between environmental factors and the development of hyperparathyroidism and should be the focus of future studies looking at chemical levels within specimens.
Scaling relations for auxin waves
Authors: Bakker Bente Hilde , Faver Timothy E. , Hupkes Hermen Jan , Merks Roeland M. H. , van der Voort Jelle 
Published: September 2022

AbstractWe analyze an ‘up-the-gradient’ model for the formation of transport channels of the phytohormone auxin, through auxin-mediated polarization of the PIN1 auxin transporter. We show that this model admits a family of travelling wave solutions that is parameterized by the height of the auxin-pulse. We uncover scaling relations for the speed and width of these waves and verify these rigorous results with numerical computations. In addition, we provide explicit expressions for the leading-order wave profiles, which allows the influence of the biological parameters in the problem to be readily identified. Our proofs are based on a generalization of the scaling principle developed by Friesecke and Pego to construct pulse solutions to the classic Fermi–Pasta–Ulam–Tsingou model, which describes a one-dimensional chain of coupled nonlinear springs.
Long-Term Effects of Cold Atmospheric Plasma-Treated Water on the Antioxidative System of Hordeum vulgare
Authors: Bussmann Frederik , Krüger Andrea , Scholz Caterina , Brust Henrike , Stöhr Christine 
Published: September 2022

AbstractFacing climate change, the development of innovative agricultural technologies securing food production becomes increasingly important. Plasma-treated water (PTW) might be a promising tool to enhance drought stress tolerance in plants. Knowledge about the effects of PTW on the physiology of plants, especially on their antioxidative system on a long-term scale, is still scarce. In this work, PTW was applied to barley leaves (Hordeum vulgare cv. Kosmos) and various constituents of the plants’ antioxidative system were analyzed 30 days after treatment. An additional drought stress was performed after foliar PTW application followed by a recovery period to elucidate whether PTW treatment improved stress tolerance. Upon PTW treatment, the Total Antioxidant Capacity (TAC) in leaves and roots was lower in comparison to deionized water treated plants. In contrast, PTW treatment caused a higher content of chlorophyll, quantum yield and total ascorbate content in leaves compared to deionized water treated plants. After additional drought application and subsequent recovery period, an enhancement of values for TAC, contents of malondialdehyde, glutathione as well as activity of ascorbate peroxidase indicated a possible upregulation of antioxidative properties in roots. Hydrogen peroxide and nitric oxide might mediate abiotic stress tolerance and are considered as key components of PTW.
Stoma versus anastomosis after sphincter-sparing rectal cancer resection; the impact on health-related quality of life
Authors: Algie Jelle P. A. , van Kooten Robert T. , Tollenaar Rob A. E. M. , Wouters Michel W. J. M. , Peeters Koen C. M. J. , Dekker Jan Willem T. 
Published: September 2022

Abstract
Background
Surgical resection is the mainstay of curative treatment for rectal cancer. Post-operative complications, low anterior resection syndrome (LARS), and the presence of a stoma may influence the quality of life after surgery. This study aimed to gain more insights into the long-term trade-off between stoma and anastomosis.

Methods
All patients who underwent sphincter-sparing surgical resection for rectal cancer in the Leiden University Medical Center and the Reinier de Graaf Gasthuis between January 2012 and January 2016 were included. Patients received the following questionnaires: EORTC-QLQ-CR29, EORTC-QLQ-C30, EQ-5D-5L, and the LARS score. A comparison was made between patients with a stoma and without a stoma after follow-up.

Results
Some 210 patients were included of which 149 returned the questionnaires (70.9%), after a mean follow-up of 3.69 years. Overall quality of life was not significantly different in patients with and without stoma after follow-up using the EORTC-QLQ-C30 (p = 0.15) or EQ-5D-5L (p = 0.28). However, after multivariate analysis, a significant difference was found for the presence of a stoma on global health status (p = 0.01) and physical functioning (p < 0.01). Additionally, there was no difference detected in the quality of life between patients with major LARS or a stoma.

Conclusion
This study shows that after correction for possible confounders, a stoma is associated with lower global health status and physical functioning. However, no differences were found in health-related quality of life between patients with major LARS and patients with a stoma. This suggests that the choice between stoma and anastomosis is mainly preferential and that shared decision-making is required.
Long-term follow-up of patients with vestibular neuritis by caloric testing and directional preponderance calculation
Authors: Molnár András , Jassoy Benjámin Donát , Maihoub Stefani , Mavrogeni Panayiota , Tamás László , Szirmai Ágnes 
Published: September 2022

Abstract
Objectives
This study focuses on the diagnostic precision of caloric testing in detecting vestibular neuritis (VN).

Materials and methods
In this study, 99 patients (36 men, 63 women, mean age: 44.63 years $$\pm$$
±
12.08 SD) with superior VN were involved, and 157 participants with a normal functioning vestibular system were also investigated. All patients underwent a complete neurotological examination, including the caloric test with electronystagmography registration. The canal paresis (CP) and directional preponderance (DP) values were analysed.

Results
A VN on the right side was diagnosed in 31.3% and on the left side in 68.7%. When the CP parameters between the control and VN patients were contrasted, a statistically significant difference was observed (p < 0.00001*, Mann–Whitney U test), indicating higher values in the latter group. The prediction of VN based on the CP value was successful in 71%, and statistical analysis indicated a significant result [p < 0.0001*; OR: 5.730 (95% CI 3.301–9.948)]. The DP values were also significantly higher in the VN group (p < 0.00001*). The prediction of VN according to the DP value was successful in 69.8%. A significant result was also observed in this case [p < 0.001*; OR: 4.162 (95% CI 2.653–8.017)]. When both CP and DP were considered, a predictive value of 84.8% with a significant outcome [p < 0.0001*; OR: 82.7 (95% CI 28.4–241.03)] was detected.

Conclusions
Including the CP and DP parameters of the caloric test, VN could be detected in around 85%. Therefore, the caloric helps diagnose the disorder, but both parameters must be considered.
Deep reinforcement learning for automated search of model parameters: photo-fenton wastewater disinfection case study
Authors: Hernández-García Sergio , Cuesta-Infante Alfredo , Moreno-SanSegundo José Ángel , Montemayor Antonio S. 
Published: September 2022

AbstractNumerical optimization solves problems that are analytically intractable at the cost of arriving at a sufficiently good but rarely optimal solution. To maximize the result, optimization algorithms are run with the guidance and supervision of a human, usually an expert in the problem. Recent advances in deep reinforcement learning motivate interest in an artificial agent capable of learning to do the expert’s task. Specifically, we present a proximal policy optimization agent that learns to optimize in a real case study such as the modeling of the photo-fenton disinfection process, which involves a number of parameters that have to be adjusted to minimize the error of the model with respect to the experimental data collected in several trials. The expert spends an average of 4 h to find a suitable set of parameters. On the other hand, the agent we present does not require a human expert to guide or validate the optimization procedure and achieves similar results in $$2.5\times$$

2.5
×

less time.
Blow up solutions for Sinh-Gordon equation with residual mass
Authors: Ao Weiwei , Jevnikar Aleks , Yang Wen 
Published: September 2022

AbstractWe are concerned with the Sinh-Gordon equation in bounded domains. We construct blow up solutions with residual mass exhibiting either partial or asymmetric blow up, i.e. where both the positive and negative part of the solution blow up. This is the first result concerning residual mass for the Sinh-Gordon equation showing in particular that the concentration-compactness theory with vanishing residuals of Brezis-Merle can not be extended to this class of problems.
Whole genome analyses based on single, field collected spores of the arbuscular mycorrhizal fungus Funneliformis geosporum
Authors: Sahraei Shadi Eshghi , Sánchez-García Marisol , Montoliu-Nerin Merce , Manyara David , Bergin Claudia , Rosendahl Søren , Rosling Anna 
Published: September 2022

AbstractArbuscular mycorrhizal (AM) fungi are ubiquitous mutualistic symbionts of most terrestrial plants and many complete their lifecycles underground. Whole genome analysis of AM fungi has long been restricted to species and strains that can be maintained under controlled conditions that facilitate collection of biological samples. There is some evidence suggesting that AM fungi can adapt to culture resulting in phenotypic and possibly also genotypic changes in the fungi. In this study, we used field isolated spores of AM fungi and identified them as Funneliformis geosporum based on morphology and phylogenetic analyses. We separately assembled the genomes of two representative spores using DNA sequences of 19 and 22 individually amplified nuclei. The genomes were compared with previously published data from other members of Glomeraceae including two strains of F. mosseae. No significant differences were observed among the species in terms of gene content, while the single nucleotide polymorphism density was higher in the strains of F. geosporum than in the strains of F. mosseae. In this study, we demonstrate that it is possible to sequence and assemble genomes from AM fungal spores sampled in the field, which opens up the possibility to include uncultured AM fungi in phylogenomic and comparative genomic analysis and to study genomic variation in natural populations of these important plant symbionts.