bluuebunny/crossref_metadata_2025_split huggingface dataset:
Kinase-independent activity of DYRK1A promotes viral entry of highly pathogenic human coronaviruses
Authors: Strine Madison S. , Cai Wesley L. , Wei Jin , Alfajaro Mia Madel , Filler Renata B. , Biering Scott B. , Sarnik Sylvia , Patil Ajinkya , Cervantes Kasey S. , Collings Clayton K. , DeWeirdt Peter C. , Hanna Ruth E. , Schofield Kevin , Hulme Christopher , Konermann Silvana , Doench John G. , Hsu Patrick D. , Kadoch Cigall , Yan Qin , Wilen Craig B. 
Published: September 2022

ABSTRACTIdentifying host genes essential for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has the potential to reveal novel drug targets and further our understanding of coronavirus disease 2019 (COVID-19). We previously performed a genome-wide CRISPR/Cas9 screen to identify pro-viral host factors for highly pathogenic human coronaviruses. Very few host factors were required by diverse coronaviruses across multiple cell types, but DYRK1A was one such exception. Although its role in coronavirus infection was completely unknown, DYRK1A encodes Dual Specificity Tyrosine Phosphorylation Regulated Kinase 1A and regulates cell proliferation, and neuronal development, among other cellular processes. Interestingly, individuals with Down syndrome overexpress DYRK1A 1.5-fold and exhibit 5-10x higher hospitalization and mortality rates from COVID-19 infection. Here, we demonstrate that DYRK1A regulates ACE2 and DPP4 transcription independent of its catalytic kinase function to support SARS-CoV, SARS-CoV-2, and MERS-CoV entry. We show that DYRK1A promotes DNA accessibility at the ACE2 promoter and a putative distal enhancer, facilitating transcription and gene expression. Finally, we validate that the pro-viral activity of DYRK1A is conserved across species using cells of monkey and human origin and an in vivo mouse model. In summary, we report that DYRK1A is a novel regulator of ACE2 and DPP4 expression that may dictate susceptibility to multiple highly pathogenic human coronaviruses. Whether DYRK1A overexpression contributes to heightened COVID-19 severity in individuals with Down syndrome through ACE2 regulation warrants further future investigation.
Organization of Upstream ESCRT Machinery at the HIV-1 Budding Site
Authors: Hudait Arpa , Hurley James H. , Voth Gregory A. 
Published: September 2022

AbstractIn the late stages of the HIV-1 life cycle, membrane localization and self-assembly of the Gag polyproteins induce membrane deformation and budding. However, release of the immature virion requires direct interaction between Gag lattice and upstream ESCRT machinery at the budding site, followed by assembly of the downstream ESCRT-III factors, culminating in membrane scission. In this work, using “bottom-up” coarse-grained (CG) molecular dynamics (MD) simulations we investigated the interactions between Gag and different upstream ESCRT components to delineate the molecular organization of proteins at the membrane neck of the HIV-1 budding site. We developed CG models of upstream ESCRT proteins and HIV-1 structural protein Gag based on experimental structural data and extensive all-atom MD simulations. We find that ESCRT-I proteins bound to the immature Gag lattice can recruit multiple copies of ESCRT-II coating the membrane neck. ESCRT-I can effectively oligomerize to higher-order complexes both in absence of ESCRT-II and when multiple copies of ESCRT-II are localized at the bud neck. The ESCRT-I/II supercomplexes observed in our simulations exhibit predominantly extended conformations. Importantly, the ESCRT-I/II supercomplex modulates the membrane mechanical properties at the budding site by decreasing the overall Gaussian curvature of membrane neck. Our findings serve to elucidate a network of interactions between the upstream ESCRT machinery, immature Gag lattice, and membrane bud neck that regulate the protein assemblies and enable bud neck constriction.
The learning model of crisis management: the COVID-19 case in the hospitality industry
Authors: Li Bin , Zhang Tingting , Chen Yuting , Hua Nan 
Published: September 2022

Purpose
This study aims to explore the underlying mechanisms that support the resilience of the Chinese hospitality industry during and after the COVID-19 epidemic.

Design/methodology/approach
Content analysis was applied to 133 manually collected text articles about COVID-19 responses and strategies.

Findings
A two-step learning model (emergency reaction, precautions and prevention stages) was identified in the study. In the emergency reaction step, the primary strategies were related to customers, employees, suppliers and facility/food. In the precautions and prevention step, the strategies were related to customers, employees, suppliers and society/public relations. Multiple stakeholders are discussed in the two circles over a continual process in the learning, reacting and adapting stages.

Originality/value
A gap in the literature is filled by this study, providing a learning model and synthesizing various strategies applied in the hotel sector for multiple stakeholders.
A networked understanding of new mathematics teachers' learning, when participating in a lesson-study induction programme
Authors: Skott Charlotte Krog 
Published: September 2022

PurposeThe purpose of the article is to identify, describe and explain what and how new mathematics teachers learn when participating in a lesson-study induction programme, by networking theories.Design/methodology/approachTo explore this phenomenon, the author combines the two theoretical frameworks, Patterns of Participation and the Knowledge Quartet. In a case study with one teacher, the latter framework is used as a zoom into the parts identified as important by the first framework.FindingsThe combination of the two frameworks proved productive as it provides: (1) a more complete insight into what the teacher learned, (2) complementary views on what and how the teacher learned and (3) different insights into the complex situations new teachers find themselves in. These findings contribute to the theorisation of lesson study and to research on new mathematics teachers.Research limitations/implicationsAs the study includes only one teacher, its results regarding new teachers' learning are not generalisable to the same extent as are the results regarding the benefits of combining the two frameworks.Practical implicationsIn Denmark and other western countries, it is crucial to provide new mathematics teachers with support that focuses specifically on mathematics education. The article proposes a design of such an induction programme based on lesson study.Originality/valueOutside East Asia, lesson study is rarely used to support the professional development of new mathematics teachers during their first teaching years. The article contributes an exploration of this phenomenon in Denmark.
The interplay between spirituality, compassion and citizenship behaviours in the lives of educators: a study
Authors: Mahipalan Manju 
Published: September 2022

Purpose
This study aims to investigate the impact of workplace spirituality on citizenship behaviours of high school teachers. In addition, the moderating role of workplace compassion is examined.

Design/methodology/approach
This study is quantitative in nature. Data were collected from 232 secondary school teachers using a structured questionnaire. Partial least squares-based structural equation modelling was used to analyse the data.

Findings
Results revealed evidence for the positive relationship between spirituality and citizenship behaviours. Compassion was found to be a potential moderator in enhancing the spirituality–citizenship behaviour connection. This study attempts to understand one of the ways in which spirituality affects workplace behaviour by specifying the role of a moderator. The complex nature of the phenomenon is delineated further by identifying the plausible relationship with other variables.

Practical implications
Organisations can leverage the spiritual resources available to their people to compound their proactive behaviours, thus creating a win–win situation for both the parties involved. This is particularly useful for educational institutions where such behaviours are not merely desirable but could significantly elevate the working environment.

Originality/value
This study evaluates the connections between spirituality, compassion and citizenship behaviour, which remain largely unexplored in a non-profit sector. The construct of workplace compassion is not sufficiently mapped, especially in a context where it is thought to be embedded in the work environment.
Tribological effect of ZBUP additive on the running-in quality of sliding bearing by fractal analysis
Authors: Wang Zhiyong , Zhou Yuankai , Zuo Xue 
Published: September 2022

Purpose
The purpose of this paper is to study the tribological effect of zinc borate ultrafine powder (ZBUP) oil additive on the running-in quality.

Design/methodology/approach
The running-in quality was assessed by friction coefficient and surface topography. Fractal parameters including fractal dimension, the width of multifractal, the multifractal difference, multifractal parameters, phase trajectory and correlation dimension were used to extract the nonlinear characteristics of surface topography and friction coefficient.

Findings
When the ZBUP additive was added, the convergence degree of the phase trajectory and the stability of the running in were higher than that of base oil. It indicates that the ZBUP additive can improve the running-in quality of sliding bearing. Besides, the ZBUP additive can shorten the running-in time. A boundary protective film, which has good friction-reducing and anti-wear effects, was generated on the surface when the ZBUP additive was added.

Originality/value
The results have a great significance to improve the running-in quality and prolong the service life of the sliding bearing.
Does e-retailer's country of origin influence consumer privacy, trust and purchase intention?
Authors: Bhattacharya Saptarshi , Sharma Rajendra Prasad , Gupta Ashish 
Published: September 2022

Purpose
Consumers are worried about sharing their sensitive information during online shopping due to the e-tailer’s unethical practices and hacking-related concerns. Prior research has established the country of origin (COO) as a trust-building cue; however, it requires empirical testing in the online retailing context. The present study aims to examine the e-tailer COO’s effect on consumer privacy, trust and purchase intention.

Design/methodology/approach
An online survey floated a seven-point Likert scale questionnaire and invited the receivers to participate in the investigation over e-mails and text messages. A total of 355 usable responses were analyzed using R programming.

Findings
This study empirically validated a proposed conceptual model examining the influence of COO on consumer privacy, trust and purchase intention. The findings suggest that COO influences consumer privacy, trust and purchase intention. This study further found that the privacy practices of online retailers positively impact consumer trust. Trust acts as a mediating factor in influencing purchase intention.

Practical implications
This study offers valuable insights for advancing the research agenda and actionable inputs to e-commerce managers for alleviating consumer privacy concerns in emerging economies. Future researchers can test the proposed model in other demographic and e-commerce settings.

Originality/value
This study contributes to the present knowledge on consumer privacy in online retailing in the Indian context. This paper also examines the relationship of COO with consumer privacy, trust and purchase intention, an underexplored research area in emerging markets.
Emerging issues in corporate entrepreneurship: evidence from the United Arab Emirates
Authors: Arnaut Marina 
Published: September 2022

Purpose
Corporate entrepreneurship (CE) has attracted considerable attention worldwide, and the challenges of managing employees’ entrepreneurial behaviours are increasingly recognised. However, the paucity of research on managers’ entrepreneurial behaviour in the United Arab Emirates multinational corporate environment creates a salient gap in the current understanding of how national and organisational cultures that not always align frame the critical problems of CE. This study aims to fill this research gap by examining multinationals’ CE antecedents drawing on an institutional perspective in Dubai.

Design/methodology/approach
The author conducts 54 in-depth interviews with middle managers in multinational enterprises. This study adopts a multiple case study research design to reveal whether an emergent discovery is exclusive to a particular case or is consistently replicated by multiple cases. The author has used abductive reasoning to systematically integrate analytical framework deduction with raw data induction.

Findings
This study’s findings indicate that CE in Dubai is ineffective and fragmented. Arguably, the cultural background of employees creates different circumstances and determinants of entrepreneurial behaviour. Hence, CE may not achieve epitome competencies without identifying multicultural nuances in an organisational context.

Originality/value
Existing research has placed relatively little emphasis on the role of individual national culture in multinational enterprises. This study’s results offer potentially valuable implications for theory, practice and future research addressing other emerging countries. This model presents a distinct CE architecture with compelling evidence for national culture (at the macro level), organisational culture, Corporate Entrepreneurship Assessment Instrument and emergent factors (at the meso level) and individual middle managers' real-life experience (at the micro level).
Examining the influence of the performance of mobile devices on teaching quality based on the technological acceptance mode
Authors: Chen Xiaozhong , Chen Rongli 
Published: September 2022

PurposeThis study aims to examine the effects of iPad distribution on all teachers in a university and its application in teaching and student learning at home via wireless network during the coronavirus (COVID-19) pandemic. The attitude towards the use of iPads, behavioural intentions and the impact on the quality of teaching were evaluated.Design/methodology/approachThis study used the technology acceptance model to explore the use of iPad smart mobile devices in multimedia teaching applications by university teachers. Furthermore, it used the structural equation modelling (SEM) for data analysis to explore the causal relationship between model variables, and it aimed to examine the causal relationship between variables to verify the theory. The SEM analysis included the following two stages: measurement model analysis and structural model analysis.FindingsThe “Internet information environment” had a significant positive impact on “perceived usefulness” and “perceived ease of use”. Amongst them, perceived usefulness had a significant positive effect on the use attitude, and use attitude had a significant positive effect on behaviour intention.Originality/valueThe findings confirmed that a good information network environment will directly and positively affect the perceived usefulness and the ease of use of iPad smart devices, of which the perceived usefulness will further positively affect teachers' perception of iPad smart devices. The attitude and behaviour of using such devices will in turn positively affect the quality of teaching. The results of the quality performance evaluation can be referenced further by manufacturers and scholars regarding the use of iPad smart devices for work at home during the COVID-19 pandemic.
Factors associated with general self-efficacy of women leaders in India
Authors: Sarkar Anita 
Published: September 2022

PurposeThe purpose of the study was to examine the impact of both work and non-work domain contextual factors (family support, workplace social support, mentoring support, networking and visible assignment) on the general self-efficacy (GSE) of women leaders in India. Also, we tried to explore whether GSE is connected to women leaders' career aspirations.Design/methodology/approachThis is a survey-based study where data was collected and analysed from 145 women leaders working in a large public sector organisation in India.FindingsResults suggest that except for workplace social support, all other factors have a significant positive impact on the GSE of women leaders. GSE is also significantly associated with women leaders' career aspirations.Originality/valueUniqueness of the article is that we have empirically tested the enablers and deterrents of women leadership in the GSE context, taking note of both work and non-work domains of women leaders. The implications of the results for women's leadership development have been detailed.
Digital literacy: an empirical study for fashion design students in India
Authors: Lahiri Suranjan , Deb Roy Anannya , Jana Prabir 
Published: September 2022

Purpose
This study aims to conduct an exploratory research to find out the evolving constructs and variables of digital literacy, as seen by researchers since its inception. This research also includes an empirical study to identify and further analyze the digital literacy dimensions of university students studying fashion design program in Kolkata, India.

Design/methodology/approach
The exploratory study is based on a review of extant literature, whereas the empirical study is carried out through a self-assessment survey based on UNESCOs Digital Literacy Global Framework competences after validating their relevance with respect to the fashion and apparel industry. A total of 120 university students studying four years Bachelor of Design (Fashion Design) program were asked to rate their digital literacy competences on a five-point Likert scale, with a self-reported truth response against each statement. The results were analyzed using multivariate statistical tools.

Findings
Based on UNESCO competences, it came out that there are eight digital literacy dimensions. ANOVA further confirms that the dimensions requiring higher-order cognition, such as “software management competence” and “digital citizenship competence,” increase with progress in the graduate program. However, lower-order competence dimensions remained unchanged over time.

Originality/value
The research instrument used for this empirical study, its identified dimensions and the fact that higher-order competence dimensions are enhanced with progression in university education may be helpful for similar research in other fashion-related programs.
The role of consciousness in sustainable food consumption: a cultural comparison
Authors: Ahn Jiseon , Shamim Amjad 
Published: September 2022

Purpose
The advent of COVID-19 was followed by an increased demand for organic products along with newfound customer interest in healthy consumption habits. This study aims to explore the impact of multidimensional consciousness on consumers’ attitudes and purchasing intentions toward organic food brands.

Design/methodology/approach
Given the importance of culture on customers’ decision-making, data were collected from the USA and India to examine the potential cultural differences with respect to organic products. A conceptual model is derived and tested using partial least squares structural equation modeling.

Findings
The results indicate that organic consciousness (e.g. for organic standards) is the most important predictor of attitudes, whereas environmental consciousness appears to be the prime motive in the formation of purchase intentions. Multidimensional (i.e. organic, environment, health and social) consciousness can predict attitude and intention. However, organic standards and social consciousness fail to directly influence customers’ purchasing intention. The impact of each dimension of consciousness varies between USA and Indian customers.

Originality/value
This study provides an understanding of customers’ sustainable consumption behavior by clarifying the relative impact of multidimensional perceived values. Also, because of the growth of organic food market globally, the findings of this study offer valuable insights by identifying the cultural difference between Western and Eastern customers’ behavior.
Production of a novel milk‐clotting enzyme from solid‐substrate Mucor spp. culture
Authors: Qasim Farhat , Diercks‐Horn Sonja , Gerlach Doreen , Schneider Anna , Fernandez‐Lahore Hector Marcelo 
Published: September 2022

AbstractCalf rennet has been traditionally used for cheese making all over the world since ancient times. It is primarily a type of aspartic protease. Calf rennet, also known as chymosin, is considered the best milk coagulant in cheese manufacturing. Its usage and demand are increasing day by day in the food industry; however, some ethical issues are also related since it is naturally present in the calf's stomach and obtained by the slaughtering of young animals. Therefore, researchers are trying to introduce some new and better alternatives for chymosin in the food industry. Mucor racemosus f. racemosus CBS 381, Mucor racemosus DSM 62760, and Aspergillus oryzae were cultivated by solid substrate fermentation using the design of experiment (DoE) (MODDE; Umetrics, Sweden) to optimize and analyze the various combinations of different factors and responses (milk‐clotting activity, proteolytic activity, specific activity). Based on the analysis of the screening and optimization results, Mucor racemosus CBS 381 was found to be the potential strain in terms of high production of aspartic protease, as well as had high milk‐clotting activity under a solid‐state fermentation system. However, molasses and casein were determined to be significant carbon and nitrogen sources, respectively, under conditions such as 70% moisture content and 25°C temperature. The molecular weight of the enzyme (Mucor CBS 381) is ∼30 KDa and it exhibits maximum activity at pH 4.8 at 45°C. The investigated enzyme was pronounced as thermal‐sensitive and lost activity completely after 10 min incubation at 55°C. The remarkable qualities of the studied enzyme, such as cost‐effective production, milk‐clotting and proteolytic activity make Mucor racemosus CBS 381 a promising alternate to calf chymosin in the cheese‐making industry.Practical ApplicationThe milk‐clotting enzyme (aspartic protease) produced by the Mucor racemosus is the alternative to calf chymosin. It can be used to produce cheese on the industrial level with some desired properties such as good taste and texture that includes gumminess. Nowadays, consumers prefer products that do not involve any animal cruelty whereas a huge group of consumers oppose the use of genetically modified enzymes. Therefore, the enzyme by Mucor racemosus would produce the cheese that is going to meet the demands of various types of cheese consumers.