bluuebunny/crossref_metadata_2025_split huggingface dataset:
Maximizing Micrograft Take in Extensive Back Burns
Authors: Ching Ann-Hui , Hong Qi-En , Chew Khong-Yik , Tan Bien-Keem 
Published: September 2022

Abstract
Extensive burns involving the back pose unique challenges. Offloading in the prone position is not possible with concomitant deep facial and neck burns. We describe our experience in maximizing graft take in a patient who had extensive back burns with concomitant anterior body burns. The two main goals in graft fixation for extensive back wounds are mechanical stabilization of micrografts to reduce shearing and prevention of water logging from exudates or bleeding to optimize contact with wound bed. Guided by the stages of wound healing, graft take, and burn care, we describe three stages of postoperative negative pressure wound therapy (NPWT) in a patient with 54% TBSA burns treated with micrografting. After complete excision of the deep dermal burns of the entire back, the wounds were covered with micrograft-allograft composites. In phase I, days 1 to 3, conventional topical negative pressure dressing with a thin sponge was applied and a leak-proof seal was achieved with gel sealant and high tack adhesive drapes. In phase II, days 4 to 5, foam dressings with topical negative pressure were applied, but with a less stringent seal, supported by wall suction. In phase III, the selective removal of allografts was initiated to facilitate expansion of micrografts. Negative pressure was continued for another 2 weeks at the most dependent site to prevent wound maceration from exudates. Micrograft take was optimized with the patient in the supine/semirecumbent position. The back wounds healed completely between 60 and 70 days without repeat micrografting. Since prone positioning was not possible in this patient, clearance of exudates and maintenance of micrograft contact with the wound bed using this technique proved successful.
Foramen of Winslow hernia: a case report of a rare life-threatening situation
Authors: Kharkhach Ayoub , Police Andrea , Mabilia Andrea , Charre Lionel 
Published: September 2022

Abstract
Internal hernias through the foramen of Winslow are considered as rare events. A 66-year-old female patient presented to our emergency department with epigastric and right upper quadrant pain associated with abdominal distention, nausea and vomiting and signs of shock. A computed tomography scan showed bowel strangulation with distended loops identified within the lesser sac. The diagnosis was confirmed by a midline laparotomy procedure. The ileum, the caecum and the ascending colon were found to herniate into the foramen of Winslow. A right hemicolectomy with a resection of the necrotic segment was performed. The patient recovered well postoperatively and was discharged on 10th day after surgery. The diagnosis and management of this rare disease remains challenging. Cross-sectional imaging with reconstruction is considered as the diagnostic modality of choice. Moreover, right hemicolectomy is a preferred procedure in order to decrease the rate of recurrence.
Modeling Group-Specific Interviewer Effects on Survey Participation Using Separate Coding for Random Slopes in Multilevel Models
Authors: Herzing Jessica M E , Blom Annelies G , Meuleman Bart 
Published: September 2022

AbstractDespite its importance in terms of survey participation, the literature is sparse on how face-to-face interviewers differentially affect specific groups of sample units. This paper demonstrates how an alternative parametrization of the random components in multilevel models, so-called separate coding, delivers valuable insights into differential interviewer effects for specific groups of sample members. In the example of a face-to-face recruitment interview for a probability-based online panel, we detect small interviewer effects regarding survey participation for non-Internet households, whereas we find sizable interviewer effects for Internet households. We derive practical guidance for survey practitioners to address differential interviewer effects based on the proposed variance decomposition.
Nilaparvata lugens salivary protein NlG14 triggers defense response in plants
Authors: Gao Haoli , Zou Jianzheng , Lin Xumin , Zhang Huihui , Yu Na , Liu Zewen 
Published: September 2022

Abstract
The brown planthopper (BPH), Nilaparvata lugens (Stål) (Hemiptera: Delphacidae), is a serious insect pest on rice. It uses its stylet to collect sap by penetrating the phloem and at the same time it delivers saliva into the host plant, which can trigger a reaction. The molecular mechanisms by which BPH salivary proteins result in plant responses are poorly understood. In this study, we screened transcriptomic data from different BPH tissues and found a protein specific to the salivary gland, NlG14, that could induce cell death in plants. We determined that NlG14 is uniquely found in the insect family Delphacidae. Detailed examination of N. lugens showed that NlG14 was mainly localized in the A-follicle of the principal gland of the salivary gland, and that it was secreted into rice plants during feeding. Knockdown of NlG14 resulted in significant nymph mortality when BPH was fed on either rice plants or on an artificial diet. Further analysis showed that NlG14 triggered accumulation of reactive oxygen species, cell death, callose deposition, and activation of jasmonic acid signaling pathways in plants. Transient expression of NlG14 in Nicotiana benthamiana decreased insect feeding and suppressed plant pathogen infection. Thus, NlG14, an essential salivary protein of N. lugens, acted as a potential herbivore-associated molecular pattern to enhance plant resistance to both insects and plant pathogens by inducing multiple plant defense responses. Our findings provide new insights into the molecular mechanisms of insect–plant interactions and offer a potential target for pest management.
Democratic Ethical Consumption and Social Justice
Authors: Albertsen Andreas 
Published: September 2022

AbstractHassoun argues that the poor in the world have a right to health and that the Global Health Impact Index provides consumers in well-off countries with the opportunity to ensure that more people have access to essential medicines. Because of this, these consumers would be ethically obliged to purchase Global Health Impact Index-labeled products in the face of existing global inequalities. In presenting her argument, Hassoun rejects the so-called democratic account of ethical consumption in favor of the positive change account. Two versions of the democratic change account are relevant. One underscores the importance of democratic procedures and institutions, while the other stresses our fundamental moral equality. While at least one prominent institutionalist account has problems, revised versions would be less vulnerable to Hassoun’s counterexamples. Furthermore, institutionalist accounts come with the epistemological gains from democratic procedures and deliberations, which may be especially important under uncertainty. Finally, and perhaps more challenging for the Global Health Impact index project, this measure may place the burden unfairly on those who need to buy medicines. This is a pivotal insight from the non-institutionalist version of the democratic account of ethical consumption.
Enhancing Global Health Impact—Beyond the Basic Minimum, Metrics and Ethical Consumption
Authors: Hassoun Nicole 
Published: September 2022

Abstract
How should we measure medicines’ global health impact to set targets, monitor performance and improve health around the world? Can such a metric provide a philosophically well-grounded basis for an ethical consumption campaign that will create incentives for pharmaceutical companies and other agents to expand (equitable) access to essential medicines? And if such metrics exist, how should we think about our individual obligations to support ethical consumption campaigns on this basis? This paper reflects on these questions in light of Tim Campbell’s, Yukiko Asada’s, and Andreas Albertsen’s worries about the answers I provide in Global Health Impact: Extending Access on Essential Medicines. I explain how reflecting on treatments consequences for individuals’ ability to live minimally well supports the creation of the Global Health Impact (GHI) index (https://global-health-impact.org/). I also consider how the index might be modified to better support efforts to promote everyone’s human rights. Finally, I argue that individuals should often promote positive change through GHI and other ethical consumption campaigns.
Commercial mHealth Apps and Unjust Value Trade-offs: A Public Health Perspective
Authors: Rossmaier Leon W S 
Published: September 2022

Abstract
Mobile health (mHealth) apps for self-monitoring increasingly gain relevance for public health. As a mobile technology, they promote individual participation in health monitoring with the aim of disease prevention and the mitigation of health risks. In this paper, I argue that users of mHealth apps must engage in value trade-offs concerning their fundamental dimensions of well-being when using mobile health apps for the self-monitoring of health parameters. I particularly focus on trade-offs regarding the user’s self-determination as well as their capacity to form personal attachments. Depending on the user’s level of advantage or disadvantage, value trade-offs can pose a threat to the users’ sufficient fulfillment of the dimensions of well-being. As such, value trade-offs can entrench existing structural injustices and prevent disadvantaged users to benefit from this technology. I argue that value trade-offs are, to some, a type of injustice that can drive disadvantaged users away from a sufficiency threshold of well-being, risk users to fall below the threshold, or have an accumulative effect on different dimensions of the user’s well-being.
Firearm Violence in the United States: An Issue of the Highest Moral Order
Authors: Iwundu Chisom N , Homan Mary E , Moore Ami R , Randall Pierce , Daundasekara Sajeevika S , Hernandez Daphne C 
Published: September 2022

Abstract
Firearm violence in the United States produces over 36,000 deaths and 74,000 sustained firearm-related injuries yearly. The paper describes the burden of firearm violence with emphasis on the disproportionate burden on children, racial/ethnic minorities, women and the healthcare system. Second, this paper identifies factors that could mitigate the burden of firearm violence by applying a blend of key ethical theories to support population level interventions and recommendations that may restrict individual rights. Such recommendations can further support targeted research to inform and implement interventions, policies and laws related to firearm access and use, in order to significantly reduce the burden of firearm violence on individuals, health care systems, vulnerable populations and society-at-large. By incorporating a blended public health ethics to address firearm violence, we propose a balance between societal obligations and individual rights and privileges.
14-3-3 proteins contribute to autophagy by modulating SINAT-mediated degradation of ATG13
Authors: Qi Hua , Lei Xue , Wang Yao , Yu Shan , Liu Ting , Zhou Shun-Kang , Chen Jin-Yu , Chen Qin-Fang , Qiu Rong-Liang , Jiang Liwen , Xiao Shi 
Published: September 2022

AbstractIn multicellular eukaryotes, autophagy is a conserved process that delivers cellular components to the vacuole or lysosome for recycling during development and stress responses. Induction of autophagy activates AUTOPHAGY-RELATED PROTEIN 1 (ATG1) and ATG13 to form a protein kinase complex that initiates autophagosome formation. However, the detailed molecular mechanism underlying the regulation of this protein complex in plants remains unclear. Here, we determined that in Arabidopsis thaliana, the regulatory proteins 14-3-3λ and 14-3-3κ redundantly modulate autophagy dynamics by facilitating SEVEN IN ABSENTIA OF ARABIDOPSIS THALIANA (SINAT)-mediated proteolysis of ATG13a and ATG13b. 14-3-3λ and 14-3-3κ directly interacted with SINATs and ATG13a/b in vitro and in vivo. Compared to wild-type (WT), the 14-3-3λ 14-3-3κ double mutant showed increased tolerance to nutrient starvation, delayed leaf senescence, and enhanced starvation-induced autophagic vesicles. Moreover, 14-3-3s were required for SINAT1-mediated ubiquitination and degradation of ATG13a. Consistent with their roles in ATG degradation, the 14-3-3λ 14-3-3κ double mutant accumulated higher levels of ATG1a/b/c and ATG13a/b than the WT upon nutrient deprivation. Furthermore, the specific association of 14-3-3s with phosphorylated ATG13a was crucial for ATG13a stability and formation of the ATG1–ATG13 complex. Thus, our findings demonstrate that 14-3-3λ and 14-3-3κ function as molecular adaptors to regulate autophagy by modulating the homeostasis of phosphorylated ATG13.
Estimating Intergenerational and Assortative Processes in Extended Family Data
Authors: Collado M Dolores , Ortuño-Ortín Ignacio , Stuhler Jan 
Published: September 2022

Abstract
We quantify intergenerational and assortative processes by comparing different degrees of kinship within the same generation. This “horizontal” approach yields more, and more distant kinship moments than traditional methods, which allows us to account for the transmission of latent advantages in a detailed intergenerational model. Using Swedish registers, we find strong persistence in the latent determinants of status, and a striking degree of sorting—to explain the similarity of distant kins, assortative matching must be much stronger than previously thought. Latent genetic influences explain little of the variance in educational attainment, and sorting occurs primarily in non-genetic factors.
Basic helix-loop-helix transcription factor PxbHLH02 enhances drought tolerance in Populus (Populus simonii × P. nigra)
Authors: Gao Shangzhu , Li Caihua , Chen Xiaohui , Li Sida , Liang Nansong , Wang Hengtao , Zhan Yaguang , Zeng Fansuo 
Published: September 2022

Abstract
The basic helix-loop-helix (bHLH) transcription factors (TFs) are involved in plant morphogenesis and various abiotic and biotic stress responses. However, further exploration is required of drought-responsive bHLH family members and their detailed regulatory mechanisms in Populus. Two bHLH TF genes, PxbHLH01/02, were identified in Populus simonii × P. nigra and cloned. The aim of this study was to examine the role of bHLH TFs in drought tolerance in P. simonii × P. nigra. The results showed that the amino acid sequences of the two genes were homologous to Arabidopsis thaliana UPBEAT1 (AtUPB1) and overexpression of PxbHLH01/02 restored normal root length in the AtUPB1 insertional mutant (upb1-1). The PxbHLH01/02 gene promoter activity analysis suggested that they were involved in stress responses and hormone signaling. Furthermore, Arabidopsis transgenic lines overexpressing PxbHLH01/02 exhibited higher stress tolerance compared with the wild-type. Populus simonii × P. nigra overexpressing PxbHLH02 increased drought tolerance and exhibited higher superoxide dismutase and peroxidase activities, lower H2O2 and malondialdehyde content, and lower relative conductivity. The results of transcriptome sequencing (RNA-seq) and quantitative real-time PCR suggested that the response of PxbHLH02 to drought stress was related to abscisic acid (ABA) signal transduction. Overall, the findings of this study suggest that PxbHLH02 from P. simonii × P. nigra functions as a positive regulator of drought stress responses by regulating stomatal aperture and promoting ABA signal transduction.
Refractory Uterine Atony: Still a Problem After All These Years
Authors: Balki M. , Wong C.A. 
Published: September 2022

(Int J Obstet Anesth. 2021;48:103207)
A substantial portion of uterine atony (up to 80%) of postpartum hemorrhage (PPH) cases can be attributed to uterine atony. Postpartum uterine atony also carries an increased risk of obstetric morbidity.
Umbilical Cord Prolapse: Revisiting its Definition and Management
Authors: Wong L.O. , Kwan A.H.W. , Lau S.L. , Sin W.T.A. , Leung T.Y. 
Published: September 2022

(Am J Obstet Gynecol. 2021;225:357–366)
Umbilical cord prolapse is an uncommon condition but is associated with high perinatal mortality, with higher rates in low-income countries. It has an incidence from 1 to 6 per 1000 pregnancies. There are still many questions around umbilical cord prolapse. This review aimed to address variations in the definition and classification, the degree of urgency in delivery when umbilical cord prolapse is present, and the efficacy of maneuvers used to relieve cord compression before delivery.
Trends in Mortality Among Pregnant and Recently Pregnant Women in the US, 2015–2019
Authors: Howard J.T. , Sparks C.S. , Santos-Lozada A.R. , Olowolaju S.A. , Janak J.C. , Howard K.J. 
Published: September 2022

(JAMA. 2021;326:1631–1633)
The United States has the highest maternal mortality rate of developed countries. By 2015, all states except Alabama and West Virginia had adopted the pregnancy checkbox on death certificates. This study reported on pregnancy-related causes of death among pregnant and recently pregnant women between 2015 and 2019 and compared the data with causes of death in all women of childbearing age.
Incidence and Risk Factors for Severe Preeclampsia, Hemolysis, Elevated Liver Enzymes, and Low Platelet Count Syndrome, and Eclampsia at Preterm and Term Gestation: A Population-based Study
Authors: Lisonkova S. , Bone J.N. , Muraca G.M. , Razaz N. , Wang L.Q. , Sabr Y. , Boutin A. , Mayer C. , Joseph K.S. 
Published: September 2022

(Am J Obstet Gynecol. 2021;225:538.e1–538.e19)
Preeclampsia is a complication of pregnancy that is among the most common in high-income countries and portents other sequelae including severe preeclampsia, eclampsia, and HELLP syndrome (hemolysis, elevated liver enzymes, and low platelet count syndrome). Prevalence of these serious diagnoses range from 0.2 to 7.6 per 1000 deliveries in high-income countries. The risk factors and gestational age-specific incidence of preeclampsia with severe features, eclampsia and HELLP syndrome is not well characterized, and previous investigations of these outcomes have been hospital-based with small numbers of patients. This study provides a large population-based inquiry into the development of these further related conditions following preeclampsia at term and preterm gestation, along with associations of maternal and clinical factors.
Congenital Zika Syndrome: A Nationwide Cohort Study in Brazil, 2015-2018
Authors: Paixao E.S. , Cardim L.L. , Costa M.C.N. , Brickley E.B. , de Carvalho-Sauer R.C.O. , Carmo E.H. , Andrade R.F.S. , Rodrigues M.S. , Veiga R.V. , Costa L.C. , Moore C.A. , França G.V.A. , Smeeth L. , Rodrigues L.C. , Barreto M.L. , Teixeira M.G. 
Published: September 2022

(N Engl J Med. 2022;386:757–767)
Zika virus circulated extensively in Brazil in the recent epidemic and is implicated as a teratogen in pregnancies by transplacental fetal exposure. A wide spectrum of effects presents as congenital Zika syndrome (CZS), ranging from no detected abnormalities to severe impacts on the central nervous system and death in infancy or childhood in 10% of cases. Observed anomalies include microcephaly, dysphagia, or epilepsy apparent at birth or infancy with first trimester Zika exposure recognized as the strongest predictive factor of severity.
Clinical Value of Early Viscoelastometric Point-of-Care Testing During Postpartum Hemorrhage for the Prediction of Severity of Bleeding; A Multicenter Prospective Cohort Study in the Netherlands
Authors: Ramler P.I. , Gillissen A. , Henriquez D.D.C.A. , Caram-Deelder C. , Markovski A.A. , de Maat M.P.M. , Duvekot J.J. , Eikenboom J.C.J. , Bloemenkamp K.W.M. , van Lith J.M.M. , van den Akker T. , van der Bom J.G. 
Published: September 2022

(Acta Obstet Gynecol Scand. 2021;100:1656–1664)
Postpartum hemorrhage (PPH) is a leading cause of maternal morbidity and mortality worldwide. Early intervention before the development of coagulopathy can reduce hemostatic impairments, preventing the need for interventions including hysterectomy and massive blood transfusion. Tests currently used during PPH to evaluate clotting status include the FIBTEM and fibrinogen measurement. Results from these tests unfortunately can take up to an hour, during which time significant blood may be lost. Results of clot firmness from FIBTEM at 5 minutes (A5 measurement) can indicate the potential for PPH in only 15 minutes. In this multicenter study in the Netherlands researchers compared blood loss within 24 hours of birth to the results of these tests to determine accuracy in predicting severe PPH with blood loss ≥2000 mL.
Differences in Obstetrical Care and Outcomes Associated With the Proportion of the Obstetrician’s Shift Completed
Authors: Yee L.M. , McGee P. , Bailit J.L. , Wapner R.J. , Varner M.W. , Thorp J.M. , Caritis S.N. , Prasad M. , Tita A.T.N. , Saade S.R. , Sorokin Y. , Rouse D.J. , Blackwell S.C. , Tolosa J.E. ,   On behalf of the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Maternal-Fetal Medicine Units (MFMU) Network
Published: September 2022

(Am J Obstet Gynecol. 2021;225:430.e1–11)
Obstetric provider decision-making may influence the quality of care. Previous studies have examined differences in provider decisions and obstetric outcomes based on time of day, though this may not accurately capture provider fatigue. This study examined provider decisions and obstetric outcomes in the context of the proportion of time completed by the provider in their work shift at the time of delivery.
The Evaluation of a Noninvasive Respiratory Volume Monitor in Mechanically Ventilated Neonates and Infants
Authors: Atkinson D.B. , Sens B.A. , Bernier R.S. , Gomez-Morad A.D. , Imsirovic J. , Nasr V.G. 
Published: September 2022

(Anesth Analg. 2022;134:141–148)
Monitoring respiratory function is an essential part of caring for children in ambulatory and hospital settings. Yet, assessing ventilation in children by physical examination is difficult due to fast respiratory rates (RRs) and small tidal volumes (TV). In addition, pulse oximeters, capnometers, and other noninvasive respiratory monitors may not reliably assess minute ventilation (MV). While pulse oximeters detect oxygen desaturation, they do not directly monitor ventilation. Capnometers have also been found unreliable in intubated children. Recently a respiratory volume monitor (RVM) (ExSpiron, Watertown, MA) has been developed to measure TV, RRs, and MV noninvasively. It has been found to be accurate in adults and children above 1 year of age. The aim of this study is to evaluate the accuracy of the RVM on RRs, TV, and MV in neonates and infants below 1 year.
Receipt of mRNA Covid-19 Vaccines and Risk of Spontaneous Abortion
Authors: Zauche L.H. , Wallace B. , Smoots A.N. , Olson C.K. ,   Oduyebo et al and the CDC v-safe Covid-19 Pregnancy Registry Team
Published: September 2022

(N Engl J Med. 2021;385:1533–1535)
Pregnant women are at increased risk of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and associated maternal and neonatal adverse outcomes. While spontaneous abortion (pregnancy loss at <20 wk of gestation) associated with severe coronavirus disease 2019 (COVID-19) vaccination data is limited, this study aimed to identify risk estimates of the COVID-19 vaccination and spontaneous abortion.