bluuebunny/crossref_metadata_2025_split huggingface dataset:
Non-overlapping requirements of ASNA-1 function for insulin secretion, cisplatin resilience, and growth revealed by genetic analysis of point mutants in C. elegans
Authors: Raj Dorota , Podraza-Farhanieh Agnieszka , Gallego Pablo , Kao Gautam , Naredi Peter 
Published: July 2022

ABSTRACTASNA1 plays an essential role in cisplatin chemotherapy response, type 2 diabetes, and heart disease. It is also an important biomarker in the treatment response of many diseases. Biochemically, ASNA1 has two mutually exclusive redox modulated roles: a tail-anchored protein (TAP) targeting function in the reduced state and a holdase/chaperone function in the oxidized state. Assigning biochemical roles of ASNA-1 to biomedical functions is crucial for successful therapy development. Our previous work showed the relevance of the C. elegans ASNA-1 homolog in modeling cisplatin response and insulin secretion. Here we analyzed two-point mutants in highly conserved residues in C. elegans ASNA-1 and identified their importance in separating cisplatin response from its roles in insulin secretion. Further, using targeted depletion we showed asna-1 tissue requirements for C. elegans growth and development. We concluded that, targeting single residues in ASNA-1 affecting Switch I/II domain function, in comparison to complete knockdown counteracted cisplatin resistance without jeopardizing other important biological functions. Taken together, our study shows that effects on health caused by ASNA1 mutations can have different biochemical bases.
Characterising replisome disassembly in human cells
Authors: Jones Rebecca M. , Ruiz Joaquin Herrero , Scaramuzza Shaun , Nath Sarmi , Henklewska Marta , Natsume Toyoaki , Romero Francisco , Kanemaki Masato T. , Gambus Agnieszka 
Published: July 2022

AbstractTo ensure faultless duplication of the entire genome, eukaryotic replication initiates from thousands of replication origins. Replication forks emanating from origins move through the chromatin until they encounter forks from neighbouring origins, at which point they terminate. In the final stages of this process the replication machinery (replisome) is unloaded from chromatin and disassembled. Work from model organisms has elucidated that during replisome unloading, the MCM7 subunit of the terminated replicative helicase is polyubiquitylated and processed by p97/VCP segregase, leading to disassembly of the helicase and the replisome, which is built around it. In higher eukaryotes (worms, frogs, mouse embryonic stem cells), MCM7 ubiquitylation is driven by a Cullin2-based ubiquitin ligase, with LRR1 as a substrate receptor. To date, most of our knowledge of replication termination comes from model organisms and embryonic systems and little is known about how this process is executed and regulated in human somatic cells. Here we thus established methods to study replisome disassembly in human model cell lines. Using flow cytometry, immunofluorescence microscopy and chromatin isolation with western blotting, we can visualise unloading of the replisome (MCM7 and CDC45) from chromatin by the end of S-phase. We observe interaction of replicative helicase (CMG complex) with CUL2LRR1and ubiquitylation of MCM7 on chromatin, specifically in S-phase, suggesting that this is a replication-dependent modification. Importantly, we are able to show that replisome disassembly in this system also requires Cullin2, LRR1 and p97, demonstrating conservation of the mechanism. Moreover, we present evidence that the back-up mitotic replisome disassembly pathway is also recapitulated in human somatic cells. Finally, while we find that treatment with small molecule inhibitors against cullin-based ubiquitin ligases (CULi) and p97 (p97i) does lead to phenotypes of replisome disassembly defects, they also both lead to induction of replication stress in somatic cells, which limits their usefulness as tools to specifically target replisome disassembly processes in this setting.
Female managers' meaningful work and commitment: organizational contexts and generational differences
Authors: Kim Eun Jee , Park Sunyoung 
Published: July 2022

PurposeThe aim of this research is to examine the relationships among family-friendly organizational culture, job characteristics, supervisor support, meaningful work, and organizational commitment for female managers. It also investigates generational differences in these relationships.Design/methodology/approachData for the study were analyzed using multi-group structural equation modeling to examine the moderating role of generational differences.FindingsThis study investigates the role of meaningful work as an agent in terms of how it influences organizational commitment for female managers. Empirical results confirm the effect of family-friendly culture on supervisor support and meaningful work, which in turn impacts organizational commitment. The findings also revealed generational differences among Baby Boomers, Generation X, and Millennials in these relationships.Originality/valueThe findings highlight the significance of investigating meaningful work on organizational commitment by examining the relationships with organizational culture, supervisor support, and job characteristics across different generational groups.
Mitigating personal protective equipment (PPE) supply chain disruptions in pandemics – a system dynamics approach
Authors: Falagara Sigala Ioanna , Sirenko Mikhail , Comes Tina , Kovács Gyöngyi 
Published: July 2022

PurposeThe coronavirus disease (COVID-19) pandemic has emerged as an unprecedented health crisis worldwide and heavily disrupted the healthcare supply chain. This study focuses on analysing the different types of disruptions occurring in personal protective equipment (PPE) supply chains during the COVID-19 pandemic and on proposing mitigation strategies that are fit to the global scale and many interdependencies that are characteristic for this pandemic. The authors construct a conceptual system dynamics model (SD) based on the literature and adjusted with the use of empirical data (interviews) to capture the complexity of a global supply chain and identify leverage points (mitigation strategies).Design/methodology/approachThis research follows a mix-methods approach. First, the authors developed a conceptual framework based on four types of disruptions that usually occur during health emergencies (direct effect, policy, supply chain strategy, and behaviourally induced disruptions). Second, the authors collected and analysed data from interviews with experts in the PPE supply chain. Based on the interviews data, the authors developed a conceptual system dynamics (SD) model that allows to capture the complex and dynamic interplay between the elements of the global supply chain system, by highlighting key feedback loops, delays, and the way the mitigation strategies can impact on them. From this analysis, the authors developed four propositions for supply chain risk management (SCRM) in global health emergencies and four recommendations for the policy and decision makers.FindingsThe SD model highlights that without a combination of mitigation measures, it is impossible to overcome all disruptions. As such, a co-ordinated effort across the different countries and sectors that experience the disruptions is needed. The SD model also shows that there are important feedback loops, by which initial disruptions create delays and shortages that propagate through the supply chain network. If the co-ordinated mitigation measures are not implemented early at the onset of the pandemic, these disruptions will be persistent, creating potential shortages of PPE and other critical equipment at the onset of a pandemic – when they are most urgently needed.Originality/valueThis research enriches the understanding of the disruptions of PPE supply chains on the systems level and proposes mitigation strategies based on empirical data and the existing literature.
A novel soft gripper with enhanced gripping adaptability based on spring-reinforced soft pneumatic actuators
Authors: Cheng Peilin , Ye Yuze , Yan Bo , Lu Yebo , Wu Chuanyu 
Published: July 2022

Purpose
Soft grippers have safer and more adaptable human–machine and environment–machine interactions than rigid grippers. However, most soft grippers with single gripping postures have a limited gripping range. Therefore, this paper aims to design a soft gripper with variable gripping posture to enhance the gripping adaptability.

Design/methodology/approach
This paper proposes a novel soft gripper consisting of a conversion mechanism and four spring-reinforced soft pneumatic actuators (SSPAs) as soft fingers. By adjusting the conversion mechanism, four gripping postures can be achieved to grip objects of different shapes, sizes and weights. Furthermore, a quasi-static model is established to predict the bending deformation of the finger. Finally, the bending angle of the finger is measured to validate the accuracy of the quasi-static model. The gripping force and gripping adaptability are tested to explore the gripping performance of the gripper.

Findings
Through experiments, the results have shown that the quasi-static model can accurately predict the deformation of the finger; the gripper has the most significant gripping force under the parallel posture, and the gripping adaptability of the gripper is highly enhanced by converting the four gripping postures.

Originality/value
By increasing the gripping posture, a novel soft gripper with enhanced gripping adaptability is proposed to enlarge the gripping range of the soft gripper with a single posture. Furthermore, a quasi-static model is established to analyze the deformation of SSPA.
Procurement system for resilient supply chain amid the COVID-19 pandemic: systematic literature review
Authors: Shivajee Veer , Singh Rajesh Kumar , Rastogi Sanjay 
Published: July 2022

Purpose
This study aims to provide a rich learning opportunity from COVID-19 crisis for making resilient supply chain by adopting new strategies for the procurement system.

Design/methodology/approach
The systematic literature review has been conducted from the year 2012 to 2022 with the objective of developing procurement system for resilient supply chain. Fifty-four research papers are selected for this study.

Findings
The study exhibits that procurement function makes a significant contribution in creating supply chain resilience in the time of COVID-19 pandemic. The COVID-19 emergency has enforced companies to operate in new ways to face supply chain disruptions. The new strategies and actions appropriate for resilient procurement system have been identified.

Research limitations/implications
This study is limited to the papers that were indexed in the Scopus database. It has also been limited to the procurement function and supply chain resilience.

Practical implications
This research highlights strategies for supply chain resilience to improve the business performance in COVID-19 or similar types of crisis.

Originality/value
The originality of this paper is to identify the strategies and new practices followed in procurement function to improve the supply chain resilience. This study suggests directions for future research on the integration of procurement and manufacturing for making resilience in the supply chain.
Psychological needs as underlying forces of halal food purchase intention
Authors: Syed Sumera , Sh Ahmad Fauziah , Shah Syed Rashid Hussain 
Published: July 2022

Purpose
During the past two decades, a tremendous increase in the trend of purchasing and consuming halal food has been witnessed both among Muslims and non-Muslims. However, the research on halal food is still inchoate and needs further exploration. Moreover, there is a dearth of research addressing the impact of intrinsic motivation on halal food purchase intention. This study aims to explore intrinsically motivated halal food purchase behaviour, by means of “self-determination theory,” which is based on innate psychological needs of autonomy, competence and relatedness.

Design/methodology/approach
A total of 308 responses were yielded from online questionnaires. Partial least squares-structural equation modeling (PLS-SEM) was then used to analyze the gathered data.

Findings
The results reveal that relatedness is the strongest driver of halal food purchase intention, followed by competence, while autonomy is found to be the weakest predictor of halal food purchase intention. The findings give marketers a new line to develop intrinsically motivated strategies with a special focus on close relationships.

Originality/value
To the best of the authors’ knowledge, this research is considered the first to explore the impact of “autonomy,” “competence” and “relatedness” on halal food purchase intention.
Understanding the subjective realties of social proof and usability for mobile banking adoption: using triangulation of qualitative methods
Authors: Alenizi Abdulrahman Saqer 
Published: July 2022

Purpose
The existing technology adoption model (TAM) has ignored the importance of social proof of credibility such as risk, security and privacy. Also, this study aims to provide understanding how the issues of usability such as interactivity, compatibility and credibility can influence the mobile banking (MB) adoption of commercial and Islamic banks. This study has offered two theoretical models which may be helpful to understand the importance of social proof of credibility during MB adoption.

Design/methodology/approach
It is exploratory study therefore the researcher used triangulation of qualitative methods such as online banking app reviews, focused group and semi structured interviews are used to understand the behavior of customers toward MB adoption.

Findings
Consumers are actively involved to take recommendations from close sources, experts, customers and crowd opinion using interactive social media platforms (SMPs). The purpose to gather information is to save from usability, risk, security and privacy issues, especially when customers share their personal and financial information with the purpose to use MB. Results reveal that people with disabilities require MB app that has adjustable size, color, text and functions. The usability issues such as system design, response time, aesthetics, personalization, installation and service quality influenced the use of MB in Islamic banks.

Originality/value
Present study has offered social proof as TAM which highlights usefulness and credibility as important factors that can create social proof on SMPs. This study provides rich insights regarding what initiatives are required to resolve the issues of usability such as interactivity, compatibility and credibility that can influence the MB adoption of commercial and Islamic banks. Another major contribution of this study is to explore the issues of MB for people with disabilities and suggest how they can improve the service quality of MB for people with disabilities.
Leveraging the value from digitalization: a business model exploration of new technology-based firms in vertical farming
Authors: Thomson Linus 
Published: July 2022

PurposeThe purpose of this paper is to investigate how new technology-based firms (NTBFs) overcome established notions of scale and scope through business model innovation, leveraging the value from digitalization.Design/methodology/approachThe study adopts an exploratory research design, drawing on a novel data set of 50 publicly available interviews with vertical farming (VF) industry leaders and insiders who represent 36 different organizations from North America and Europe.FindingsThe study develops a framework showing how NTBFs leverage the value from digitalization via a paradoxical approach combining both efficiency and novelty value drivers.Originality/valueThe study extends current theorizing on the desirability of a combined business model approach leveraging both efficiency and novelty from digitalization. Furthermore, the study is among the first to investigate the unique and highly technological context of VF.
Creating digital ecosystem for small and medium enterprises: the role of dynamic capability, agile leadership and change readiness
Authors: Adhiatma Ardian , Fachrunnisa Olivia , Nurhidayati Nurhidayati , Rahayu Tina 
Published: July 2022

Purpose
The digitization efforts for small and medium enterprises (SMEs) as a result of advances in information technology are challenging, with one of them being the creation of digital ecosystems for SMEs. This study aims to develop a model of the relationship between SMEs’ readiness to change, agile leadership and dynamic capability to implement a digital ecosystem for SMEs in the creative industry in Semarang, Central Java, Indonesia.

Design/methodology/approach
A survey methodology was used in this study. Respondents in this study were creative industry SMEs in Semarang, Central Java, Indonesia. SMEs in the creative industry sector were chosen as samples as they require digital technology to manage their business development, production and distribution, customer relationships and to innovate in their businesses. In total, 250 creative SMEs, selected based on a purposive random sampling method, were included in this study. Data were analyzed using structural equation model-partial least square.

Findings
This study provides current insights and future needs for implementing digital ecosystems in SMEs in Indonesia’s creative industries. It also identifies three critical conditions for dealing with Industry 4.0: organizational readiness to change, agile leadership and dynamic capability.

Originality/value
In response to information technology advancements, this study proposes a new model for implementing digital ecosystems for SMEs. Furthermore, this study adds knowledge about the concept of a service-oriented technology ecosystem to help SMEs operate more efficiently. It focuses on the interaction of entities to improve the system’s utility, gain benefits and promote information exchange.
Reflective thinking, ambiguity tolerance, and knowledge sharing: application of the motivation-opportunity-ability framework
Authors: Endres Megan Lee , Chowdhury Sanjib K. 
Published: July 2022

PurposeThe purpose of this study is to apply the motivation–opportunity–ability (MOA) framework to investigate the relationships between ambiguity tolerance (AT), reflective thinking (RT) and performance in a complex task to predict knowledge-sharing intent.Design/methodology/approachIn this study, 190 subjects performed a complex scheduling task in which they were randomly assigned to either participate in RT or not.FindingsResults show that factors of the MOA framework positively predicted knowledge-sharing intent. In addition, RT significantly increased intention to share for individuals with low performance or with low AT.Research limitations/implicationsMore research is needed to determine relationships between complex task performance and knowledge sharing, and the role of learning strategies, particularly self-directed ones such as RT. Future studies may use a larger sample size for more complex analysis.Practical implicationsRT may be used to create a sustainable and low-cost method of increasing knowledge sharing in complex tasks, without which those with low AT or low performance may not have participated.Originality/valueThe study supports the importance of contextual influences and points to how organizations can use RT in addition to individual motivation and ability to encourage knowledge sharing.
Religion, conspiracy theory and consumer ethics: a moderated mediation analysis
Authors: Arli Denni 
Published: July 2022

PurposeThe purpose of this study is to show that the spread of conspiracy theories has resulted in many tragic incidents, such as January 6 Insurrection at the US Capitol Building. Interestingly, many of the conspiracy theory followers are religious individuals. In response to this phenomenon, this study will investigate the impact of religious (un)beliefs on consumer ethics. Secondly, this study will investigate the mediating role of conspiracy theory on consumer ethics. Finally, this study will investigate the moderating role of ethical ideology (i.e. relativism) on the relationship between consumers’ (un)belief (e.g. religiosity and atheism) and consumer ethics.Design/methodology/approachOverall, 328 participants living in the USA (32% female and 68% male) were recruited from Amazon Mechanical Turk (MTurk) in exchange for financial compensation.FindingsThe results show the negative impact of a belief in a conspiracy theory. These conspiracy beliefs can skew any individual irrespective of their beliefs or unbelief. Religious leaders, policymakers and educators need to keep this in mind when designing a campaign to reduce unethical behavior. Everyone is prone to conspiracy theories.Originality/valueThis is one of the first few studies exploring the impact of belief in conspiracy theories on consumers’ ethical beliefs. There are still limited studies investigating whether conspiracy beliefs lead individuals to engage in unethical behavior.
Exploring dietary diversity, nutritional status of adolescents among farm households in Nigeria: do higher commercialization levels translate to better nutrition?
Authors: Otekunrin Olutosin Ademola , Otekunrin Oluwaseun Aramide 
Published: July 2022

Purpose
This study aims to explore dietary diversity (DD) and nutritional status of adolescents among rural farm households in Southwestern Nigeria. It analyses whether higher commercialization levels of farm households translate to better nutrition.

Design/methodology/approach
This study was conducted in Ogun and Oyo States of Southwestern Nigeria, using primary data from 352 farm households with a total of 160 adolescent members. The individual version of dietary diversity score (DDS) of nine food groups was used to calculate adolescent DDS over a 24-h recall period. World Health Organization AnthroPlus software was used in analyzing adolescents’ anthropometric data (height-for-age z-score and body mass index-for-age z-score) while household crop commercialization index (CCI) was estimated for each farm household. Separate logit models were used to examine the drivers of adolescents’ DD and malnutrition.

Findings
The study findings indicated that 100% of the adolescents consumed starchy staples while 0%, 3.1% and 12.5% consumed organ meat, milk/milk products and eggs, respectively. Results revealed that 74.1% and 21.2% of boys were stunted and thin while the prevalence in adolescent girls was 50.7% and 9.3%, respectively. Prevalence of stunting was found to be very high (60%–83%) in all the four CCI levels’ households indicating that belonging to highly commercialized households (CCI 3–4) may not necessarily translate to better nutrition of adolescent members. Food expenditure (p < 0.01) and access to piped water (p < 0.01) negatively influenced adolescents’ stunting mainly because of lower expenditure on food items and lower percent of household having access to piped water, respectively, while education (p < 0.01) had positive effects on adolescents’ DD.

Originality/value
Previous studies have contributed to the body of knowledge concerning the link between agricultural commercialization and nutrition using under-five children of the households. However, to the best of the authors’ knowledge, this is the first study that investigated the influence of CCI on DDS and nutritional status of adolescent members of farm households in Nigeria. This study fills this existing knowledge gap in investigating adolescents’ DD and malnutrition among smallholder farm households.