bluuebunny/crossref_metadata_2025_split huggingface dataset:
Model for Integration of Monogenic Diabetes Diagnosis Into Routine Care: The Personalized Diabetes Medicine Program
Authors: Zhang Haichen , Kleinberger Jeffrey W. , Maloney Kristin A. , Guan Yue , Mathias Trevor J. , Bisordi Katharine , Streeten Elizabeth A. , Blessing Kristina , Snyder Mallory N. , Bromberger Lee A. , Goehringer Jessica , Kimball Amy , Damcott Coleen M. , Taylor Casey O. , Nicholson Michaela , Nwaba Devon , Palmer Kathleen , Sewell Danielle , Ambulos Nicholas , Jeng Linda J.B. , Shuldiner Alan R. , Levin Philip , Carey David J. , Pollin Toni I. 
Published: June 2022

OBJECTIVE
To implement, disseminate, and evaluate a sustainable method for identifying, diagnosing, and promoting individualized therapy for monogenic diabetes.

RESEARCH DESIGN AND METHODS
Patients were recruited into the implementation study through a screening questionnaire completed in the waiting room or through the patient portal, physician recognition, or self-referral. Patients suspected of having monogenic diabetes based on the processing of their questionnaire and other data through an algorithm underwent next-generation sequencing for 40 genes implicated in monogenic diabetes and related conditions.

RESULTS
Three hundred thirteen probands with suspected monogenic diabetes (but most diagnosed with type 2 diabetes) were enrolled from October 2014 to January 2019. Sequencing identified 38 individuals with monogenic diabetes, with most variants found in GCK or HNF1A. Positivity rates for ascertainment methods were 3.1% for clinic screening, 5.3% for electronic health record portal screening, 16.5% for physician recognition, and 32.4% for self-referral. The algorithmic criterion of non–type 1 diabetes before age 30 years had an overall positivity rate of 15.0%.

CONCLUSIONS
We successfully modeled the efficient incorporation of monogenic diabetes diagnosis into the diabetes care setting, using multiple strategies to screen and identify a subpopulation with a 12.1% prevalence of monogenic diabetes by molecular testing. Self-referral was particularly efficient (32% prevalence), suggesting that educating the lay public in addition to clinicians may be the most effective way to increase the diagnosis rate in monogenic diabetes. Scaling up this model will assure access to diagnosis and customized treatment among those with monogenic diabetes and, more broadly, access to personalized medicine across disease areas.
A Model for Integration of Monogenic Diabetes Diagnosis into Routine Care: The Personalized Diabetes Medicine Program
Authors: Zhang Haichen , Kleinberger Jeffrey W. , Maloney Kristin A. , Guan Yue , Mathias Trevor J. , Bisordi Katharine , Streeten Elizabeth A. , Blessing Kristina , Snyder Mallory N. , Bromberger Lee , Goehringer Jessica , Kimball Amy , Damcott Coleen M. , Taylor Casey O. , Nicholson Michaela , Nwaba Devon , Palmer Kathleen , Sewell Danielle , Ambulos Nicholas , Jeng Linda J.B. , Shuldiner Alan R. , Levin Philip , Carey David J. , Pollin Toni I. 
Published: June 2022

<p> </p>
<p><strong>Objective:</strong> To implement, disseminate and evaluate a sustainable method for identifying, diagnosing, and promoting individualized therapy for monogenic diabetes. </p>
<p><strong>Research Design and Methods:</strong> Patients were recruited into the implementation study through a screening questionnaire completed in the waiting room or through the patient portal, physician recognition, or self-referral. Patients suspected of monogenic diabetes based on the processing of their questionnaire and other data through an algorithm underwent next-generation sequencing for 40 genes implicated in monogenic diabetes and related conditions.</p>
<p><strong>Results:</strong> Three hundred thirteen probands with suspected monogenic diabetes (but most diagnosed with type 2 diabetes) were enrolled from October 2014 to January 2019. Sequencing identified 38 individuals with monogenic diabetes, with most variants found in <em>GCK</em> or <em>HNF1A</em>. Positivity rates for ascertainment methods were 3.1% in clinic screening, 5.3% in EHR portal screening, 16.5% for physician recognition, and 32.4% for self-referral. The algorithm criterion of non-type 1 diabetes before age 30 years had an overall positivity rate of 15.0%. </p>
<p><strong>Conclusions:</strong> We successfully modeled the efficient incorporation of monogenic diabetes diagnosis into the diabetes care setting, using multiple strategies to screen and identify a subpopulation with a 12.1% prevalence of monogenic diabetes by molecular testing. Self-referral was particularly efficient (32% prevalence), suggesting that educating the lay public in addition to clinicians may be the most effective way to increase the diagnosis rate of monogenic diabetes. Scaling up this model will assure access to diagnosis and customized treatment for monogenic diabetes and more broadly access to personalized medicine across disease areas. </p>
Investigating Translation Techniques through Theme-Rheme Analysis
Authors: Ulwiyah Imaratul 
Published: June 2022

ABSTRACT Translation is the process of transferring a message from one language to another with consideration to the equivalence. In the practice of translation, forms may change. The practice of translation should be done on the basis of linguistic theories as tools. Since the translator is concerned exclusively and continuously with meaning, it is not surprising that Halidayan linguistics which sees language primarily as a meaning potential should offer itself as a serviceable tool for determining the constituent part of a source language text network of relations with its translation. Therefore, this research will identify the translation technique through the information structure theories (Theme-Rheme) and its readability in BabyShark StoryBook Series. The method used in this study is qualitative descriptive. The data collection was conducted by using observation and note-taking techniques. Ten young children became target readers for the assessment to the readability of the translated text. The results show that the Theme-Rheme analysis can lead to find the translation techniques which were applied. They are Modulation, Transposition, Reduction and Amplification. The data reported here appear to support the assumption that the translator applied linguistic simplification and over explicitation in order to children fully grasp the text.Keywords:translation, theme-rheme, translation technique, readability
The Function of English Usage on Linguistic Landscape of Padang: A Case Study on Khatib Sulaiman Street
Authors: Zahara Ikrima , Wijana Dewa Putu 
Published: June 2022

This study deals with linguistic landscape found on Khatiib Sulaiman Street, Padang. The aim of the study is to identify the dominant language of the monolingual, bilingual and multilingual signs and to investigate the function of English displayed on the signs. Thus, this study uses mixed method, quantitative and qualitative, since the data and the analysis of this study is in the form of pictures and text and the justification is proven by the percentage. By using multilingualism approach on a linguistic landscape research, 236 pictures of signs displayed on Khatib Sulaiman Street as the data of this study were collected on July, 2021, and then was classfied to be monolingual, bilingual, or multilingual based on the languages that exist on each sign. This research found that there are 117 signs in Bahasa Indonesia-only, 14 signs in English-only, 82 signs in Bahasa Indonesia-English, 12 signs in Bahasa Indonesia-Minangnese, 6 signs in Bahasa Indonesia-Arabic, 3 signs in Bahasa Indonesia-English-Minangnese, and 2 signs in Bahasa Indoensia-English-Arabic. Monolingual signs are dominated by Bahasa Indonesia indicating that national languages still has the strongest position. Foreign language that is predominant in bilingual and multilingual signs is English. Gorter (2006) divides types of signs in linguistic landscape into two: bottom-up and top-down, type of sign that uses English the most is type bottom-up, displayed to live both informative function, which are to tell the name of shops and to do marketing and symbolic function, which are to symbolize modernity, sophistication, professionalism, and social status.
Blended Learning, The International Chinese Learning Trend In Post-Pandemic Era
Authors: Qadriani Nanda Lailatul 
Published: June 2022

In the early days of the Covid-19 pandemic, Chinese online learning faced many challenges, including (1) poor internet connection and high internet costs; (2) low computational literacy of teachers; (3) limited interaction between teachers and students; (4) inappropriate teaching materials and methods; and (5) the lack of student discipline and the difficulty of providing assessments. However, these challenges have turned into opportunities for the rapid development of online Chinese learning over time. Academics in China predict that online Chinese learning will be maintained in the post-pandemic era, the blended learning will become a learning trend that is applied globally. This research is descriptive qualitative research with data collection techniques through literature study method and Forum Group Discussion (FGD). The result of this study is a description of the solution to the challenges of Chinese online learning globally during the pandemic, blended learning, and its implementation strategy in the post-pandemic era based on the “Chinese Proficiency Grading Standards for International Chinese Language Education” issued in 2021.
Decay of Web References in Academic Publications: A Case of Turkish Librarianship Journal
Authors: YAYLA Kemal 
Published: June 2022

Amaç: Bu çalışmada Türk Kütüphaneciliği dergisindeki web alıntılarının erişim sorunlarının belirlenmesi amaçlanmaktadır.
Yöntem: Bu amaçla Türk Kütüphaneciliği dergisinin 2005-2020 yılları arasındaki hakemli çalışmaların DergiPark arşivinden bibliyografik kayıtları indirilmiş ve seçilen yayın türlerine göre web alıntıları elde edilmiştir. Daha sonra web alıntılarının kullanım oranları, erişim seviyeleri, URL'lerin yarılanma ömürleri ve üst seviye alan adlarının erişilebilirliği analiz edilmiştir.
Bulgular: Türk Kütüphaneciliği dergisi hakemli makalelerinde web alıntılarının sıklıkla kullanıldığı görülmüş ve son yıllarda kullanım eğiliminin sürekli artış gösterdiği anlaşılmıştır. Web alıntılarının ortalama yarılanma ömrü 3 yıldır. Ayrıca yakın tarihli makalelerde kullanılan web alıntılarının erişilebilirlik oranının öncekilere göre daha yüksek olduğu görülmüştür.
Sonuç: Bulgular, Türk Kütüphaneciliği dergisinin web alıntılarında kalıcı bozulma ve erişilebilirlik sorunları olduğunu ortaya koymuş ve web alıntılarının erişilebilirliğini artırmak için dijital işaretçilerin kullanımını teşvik eden destek politikalarının geliştirilmesi gerektiğini göstermiştir.
Özgünlük: Bu çalışma Türkçe akademik literatürde Türkiye adresli makalelerin web alıntılarına erişim sorunlarını inceleyen ilk çalışmadır.
Análisis de la percepción de estudiantes universitarios sobre hábitos en comentarios argumentativos de textos
Authors: Pérez Alcaraz Patricia , Caro Valverde María Teresa 
Published: June 2022

Esta investigación explora costumbres académicas de estudiantes de Grado de Educación Primaria sobre metodología y recursos didácticos utilizados para analizar textos argumentativos y para producir comentarios argumentativos de textos multimodales. Se encuadra en una metodología cuantitativa de corte descriptivo, con recogida de datos mediante cuestionario de escala tipo Likert. Los objetivos exploratorios se centran en indagar costumbres relativas al trabajo en clase del comentario de texto oral y escrito, al empleo de comentarios filológicos y críticos, a la formación recibida sobre análisis y producción de textos argumentativos, a la revisión docente y la autorrevisión de comentarios argumentativos, así como a las dificultades encontradas en tales procesos discursivos. Los resultados obtenidos muestran el uso escaso de comentarios de texto, tanto orales como escritos, en las aulas en educación superior, así como la falta de oportunidades formativas en su vida académica para desarrollar su capacidad crítica a través de la interpretación y la producción de textos argumentativos. Por tanto, el análisis de las costumbres académicas exploradas permite concluir la evidencia de un importante déficit formativo sobre las prácticas comunicativas propias del comentario argumentativo y proponer como mejora la propuesta de iniciativas didácticas colegiadas donde se promueva el uso estratégico de recursos teórico-prácticos relacionados con la argumentación y su desarrollo discursivo en el comentario, dado que la defensa y la elaboración de argumentos es competencia básica y el fomento del comentario crítico de textos es competencia de tal titulación.
Detecting the vulnerable carotid plaque: the Carotid Artery Multimodality imaging Prognostic study design
Authors: Gargani Luna , Baldini Matteo , Berchiolli Raffaella , Bort Ida Rebecca , Casolo Giancarlo , Chiappino Dante , Cosottini Mirco , D’Angelo Gennaro , De Santis Mariella , Erba Paola , Fabiani Iacopo , Fabiani Plinio , Gabbriellini Ilaria , Galeotti Gian Giacomo , Ghicopulos Irene , Goncalves Isabel , Lapi Simone , Masini Gabriele , Morizzo Carmela , Napoli Vinicio , Nilsson Jan , Orlandi Giovanni , Palombo Carlo , Pieraccini Francesco , Ricci Stefano , Siciliano Gabriele , Slart Riemer H.J.A. , De Caterina Raffaele 
Published: June 2022

BackgroundCarotid artery disease is highly prevalent and a main cause of ischemic stroke and vascular dementia. There is a paucity of information on predictors of serious vascular events. Besides percentage diameter stenosis, international guidelines also recommend the evaluation of qualitative characteristics of carotid artery disease as a guide to treatment, but with no agreement on which qualitative features to assess. This inadequate knowledge leads to a poor ability to identify patients at risk, dispersion of medical resources, and unproven use of expensive and resource-consuming techniques, such as magnetic resonance imaging, positron emission tomography, and computed tomography.ObjectivesThe Carotid Artery Multimodality imaging Prognostic (CAMP) study will: prospectively determine the best predictors of silent and overt ischemic stroke and vascular dementia in patients with asymptomatic subcritical carotid artery disease by identifying the noninvasive diagnostic features of the ‘vulnerable carotid plaque’; assess whether ‘smart’ use of low-cost diagnostic methods such as ultrasound-based evaluations may yield at least the same level of prospective information as more expensive techniques.Study designWe will compare the prognostic/predictive value of all proposed techniques with regard to silent or clinically manifest ischemic stroke and vascular dementia. The study will include ≥300 patients with asymptomatic, unilateral, intermediate degree (40–60% diameter) common or internal carotid artery stenosis detected at carotid ultrasound, with a 2-year follow-up. The study design has been registered on Clinicaltrial.gov on December 17, 2020 (ID number NCT04679727).
An acceptance and commitment training program reduces burden transfer, stress, and burnout among veterinary healthcare teams
Authors: Beth Spitznagel Mary , Updegraff Alanna S. G. , Was Christopher , Martin John T. , Sislak Meg , Wiborg Lisa , Twohig Michael P. 
Published: June 2022

Abstract

OBJECTIVE
To determine whether an acceptance and commitment training (ACT) program targeting reactions to difficult client interactions would reduce burden transfer, stress, and burnout among veterinary healthcare teams.

SAMPLE
Small animal veterinary hospital employees randomly assigned to participate in an ACT program (intervention group; n = 72) or to not undergo the training program (control group; 71).

PROCEDURES
The study was designed as a randomized, controlled, parallel-arms trial. All participants completed prestudy assessments of burden transfer, stress, and burnout. The ACT program consisted of 3 small-group–format educational sessions tailored to reducing reactivity to difficult veterinary client interactions; sessions were delivered via video teleconference. At the end of the educational sessions (posttest) and 1 month later (1-month follow-up), assessments of burden transfer, stress, and burnout were repeated, and participants in the intervention group provided ratings of program helpfulness and frequency of use for techniques taught in the program.

RESULTS
Participants receiving the program rated it as helpful and reported frequent use of program techniques. Relative to the control group, the intervention group showed significantly reduced burden transfer, stress, work-related burnout, and client-related burnout after completing the educational sessions. These improvements were maintained at the 1-month follow-up.

CLINICAL RELEVANCE
Findings support the usefulness of this program in reducing occupational distress in veterinary medicine. Future work is needed to examine whether it is similarly effective in formats that could be more broadly disseminated (eg, asynchronous, self-paced, independent learning).
The association of air pollutants (CO2, MTBE) on Candida albicans and Candida glabrata drug resistance
Authors: Ghazanfari Sahar , Mohammadi Shahla Roudbar , Rezaie Sassan , Khodavaisy Sadegh , Samadani Ali Akbar 
Published: June 2022

Abstract

Introduction
Therapeutic methods are very important in the prevalence of opportunistic fungal infections, which are an important cause of human diseases. In this study, air pollution agents that are in direct contact with microorganisms, and the effects of carbon sources using CO2 and MTBE on growth of fungi, and particularly the evaluation of changes in the expression of interfering genes in susceptibility and drug resistance in these fungi, were investigated.

Materials and Methods
Collecting samples and isolating Candida glabrata and Candida albicans with phenotypic methods were accomplished. We then evaluated the minimum inhibitory concentration (MIC) with the M27A4 protocol of CLSI. We adjusted 20 strains of C. albicans and 10 strains of C. glabrata whose sensitivity was evaluated in the MIC test with 5% CO2 and 5mg/ml methyl tert-butyl ether (MTBE) considered as air pollutants, and followed by re-evaluating MIC testing to separate azole-resistant strains. Interfering agents were also considered.

Results
Upregulation of some genes on the two mentioned yeasts had led to drug resistance in them; they were previously sensitive to both drugs. Correspondingly, 41% of C. glabrata samples in sputum showed sensitivity to these drugs. Upregulation of ERG11 (71%) and EPA1 (90%) were observed in resistant strains. Upregulation of genes associated with aspartate proteins and downregulation of SAP3 genes were recognized in C. glabrata in sputum and a 15% downregulation of bronchoalveolar lavage (BAL) isolate and 50% upregulation of SAP1 gene in C. albicans sensitive samples were observed and compared to fluconazole and itraconazole with the oral and joint sources. Remarkably, decreased SAP2 expression in oral sources and a 60% increase in resistant strains in C. albicans were observed. The downregulation of SAP3 expression showed in the joint samples. An increase in HWP1 expression (30%) was noted in isolated and drug-sensitive samples at the sputum and BAL source. CDR1 expression was increased in MTBE-affected species; however, it decreased in the vicinity of CT.

Conclusions
Air pollutants such as CO2 and MTBE eventually caused drug resistance in Candida, which can be one of the causes of drug resistance in candidiasis infections.
Optimal control of advection-diffusion problems for cropping systems in polluted soils
Authors: Louison Loïc , Omrane Abdennebi 
Published: June 2022

Abstract
The article studies the nutrient transfer mechanism for cropping systems in polluted soils from a mathematical and optimal control point of view. The problem under consideration is governed by an advection-diffusion PDE in a bounded domain.
The existence of a solution is obtained. We also determine the optimal amount of required nutrients at the root surface for plants where the soil is polluted by an unknown source. The characterization of the optimal control by a singular optimality system is obtained.
Partial observability of finite dimensional linear systems
Authors: Danine Mohamed Elkhail , Bernoussi Abdes Samed , Fekih Abdelaziz Bel 
Published: June 2022

Abstract
In this work, we consider the partial observability problem for finite dimensional dynamical linear systems that are not necessarily observable. For that purpose we introduce the so called “observable subspaces” and “partial observability” to find a way to reconstruct the observable part of the system state. Some characterizations of “observable subspaces” have been provided. The reconstruction of the orthogonal projection of the state on the observable subspace is obtained. We give some examples to illustrate our theoretical approach.
Intravenous treatment adherence of patients with chronic inflammatory rheumatic diseases during the COVID-19 pandemic: experience of a single center
Authors: Konak Hatice Ecem , Armağan Berkan , Güven Serdar Can , Atalar Ebru , Karakaş Özlem , Esmer Serdar , Eksin Mehmet Akif , Polat Bünyamin , Apaydin Hakan , Gök Kevser , Doğan İsmail , Erden Abdulsamet , Maraş Yüksel , Küçükşahin Orhan , Omma Ahmet , Erten Şükran 
Published: June 2022

Abstract

Introduction: Patients with chronic inflammatory rheumatic diseases (CIRD) who receive intravenous therapy requiring hospitalization are likely to be more affected than those with receiving oral therapy during COVID-19 pandemic. We aimed to investigate the effect of the COVID-19 pandemic on adherence to treatment in patients with CIRD receiving intravenous treatments.

Methods: We evaluated patients with CIRD who were treated with intravenous immunosuppressive therapy such as rituximab (RTX), cyclophosphamide (CTX), infliximab (IFX), tocilizumab (TCZ) and abatacept (ABA) in our inpatient rheumatology clinic. The patientsʼ medical treatment compliance and clinical follow-up were evaluated. Treatment discontinuation was decided according to postponement of at least one dose and discontinuation of CIRD treatments. Demographics and clinical characteristics were compared between treatment-incompliant (TI) and treatment-compliant (TC) groups.

Results: A total of 181 CIRD patients were enrolled. Rheumatoid arthritis was the most common disease requiring intravenous immunosuppressive treatment followed by axial spondyloarthritis and Behçet’s disease. Joint involvement was the most common followed by lung and kidney involvements. Rituximab was the most widely used intravenous immunosuppressive treatment for the CIRD. 34% patients have postponed at least one dose of their intravenous CIRD treatment and 25% discontinued. Fear of COVID-19 and SARS-CoV-2 positivity were the most common reasons. The TI group had a longer disease duration and a higher frequency of inflammatory arthritis than the TC group (p=0.013 and p=0.044, respectively).

Conclusions: Fear of COVID-19 and SARS-CoV-2 positivity seemed to be the major reasons for discontinuing/postponing intravenous treatments in CIRD patients. Patients with long disease duration and less systemic involvement may be more prone to discontinuing their treatments.