bluuebunny/crossref_metadata_2025_split huggingface dataset:
Parameter Determination Method of Soil Constitutive Model Based on Machine Learning
Authors: Song Zhibin , Liu Shurong , Jiang Mingyue , Yao Suling 
Published: March 2022

In order to better determine the model parameters and improve the safety and stability of construction, an optimized identification method of constitutive model parameters with improved RCGA is proposed by combining the current optimization theory. The experimental results indicate that the improved RCGA algorithm proposed in the study has stronger recognition capabilities and optimization effects than the traditional NSGA-II algorithm and determine the parameters of the constitutive model more accurately. Moreover, it is found that the parameters obtained by the proposed improved algorithm have validity and accuracy, when parameter

P

0

′

=
50

kPa, comparing the obtained optimal parameters with the real laboratory clay parameters.
Dietary Regimen, Overweight, and Obesity in Human Nutrition Students and Other Majors: A Cross-Sectional Study
Authors: Solís-Guevara Fernando D. , Ruiz Mamani Percy G. , Saintila Jacksaint 
Published: March 2022

Background. Choosing a healthy diet is an increasingly a challenge for university students. The objective of this study was to compare diet and overweight/obesity in human nutrition students (HNS) and students of other careers (SOC) from a university located in Lima, Peru. Methods. It was a cross-sectional study consisting of 158 students out of an initial sample of 170. Information was collected on the sociodemographic and anthropometric characteristics of the participants and a validated questionnaire was applied to evaluate the frequency of food consumption. Results. There was no significant difference in diet between HNS and SOC (

p

> 0.05). HNS most frequently consumed yellow/orange vegetables (

p

= 0.020), purple vegetables (

p

= 0.049), citrus fruits (

p

= 0.029), eggs (

p

= 0.002), whole milk (

p

= 0.013), yogurt (

p

= 0.017), tofu (

p

= 0.003), olive oil (

p

= 0.003), other vegetable oils (

p

< 0.001), and alcoholic beverages (

p

= 0.037) than SOC. In contrast, HNS had a lower frequency of nonfried tuber intake (

p

= 0.039), fried tubers (

p

< 0.001), milk desserts (

p

= 0.048), flour fritters (

p

= 0.027), cookies with chocolate (

p

= 0.050), croissants (

p

= 0.030), cookies with filling (

p

= 0.024), candies (

p

= 0.006), and soda (

p

= 0.016) than SOC. Overweight/obesity was not different between HNS and SOC (

p

> 0.05). Conclusions. This study found significant differences in the consumption of some foods between HNS and SOC. However, it found no significant difference in diet and overweight/obesity between HNS and SOC.
Adjuvant Osimertinib in EGFR-Mutant Early-Stage NSCLC: Does HRQoL Influence Decisions?
Authors: Patil Tejas , Bunn Paul A. 
Published: March 2022

SummaryThe ADAURA adjuvant randomized trial demonstrated that osimertinib prolonged DFS. It has now been reported that health-related quality of life (HRQoL) was not adversely affected by adjuvant osimertinib. Does this mean that adjuvant osimertinib should now be standard as we await survival results?See related article by Majem et al., p. 2286
BRAFV600E-Driven Lung Adenocarcinoma Requires Copper to Sustain Autophagic Signaling and Processing
Authors: Tsang Tiffany , Gu Xingxing , Davis Caroline I. , Posimo Jessica M. , Miller Zoey A. , Brady Donita C. 
Published: March 2022

Abstract

The transition metal copper (Cu) is an essential micronutrient required for development and proliferation, but the molecular mechanisms by which Cu contributes to these processes is not fully understood. Although traditionally studied as a static cofactor critical for the function of Cu-dependent enzymes, an expanding role for Cu is emerging to include its novel function as a dynamic mediator of signaling processes through the direct control of protein kinase activity. We now appreciate that Cu directly binds to and influences MEK1/2 and ULK1/2 kinase activity, and show here that reductions in MAPK and autophagic signaling are associated with dampened growth and survival of oncogenic BRAF-driven lung adenocarcinoma cells upon loss of Ctr1. Efficient autophagy, clonogenic survival, and tumorigenesis of BRAF-mutant cells required ULK1 Cu-binding. Although treatment with canonical MAPK inhibitors resulted in the upregulation of protective autophagy, mechanistically, the Cu chelator tetrathiomolybdate (TTM) was sufficient to target both autophagic and MAPK signaling as a means to blunt BRAF-driven tumorigenic properties. These findings support leveraging Cu chelation with TTM as an alternative therapeutic strategy to impair autophagy and MAPK signaling. As traditional MAPK monotherapies initiate autophagy signaling and promote cancer cell survival.

Implications:
We establish that copper chelation therapy inhibits both autophagy and MAPK signaling in BRAFV600E-driven lung adenocarcinoma, thus overcoming the upregulation of protective autophagy elicited by canonical MAPK pathway inhibitors.
The gRASs Is Greener: Potential New Therapies in Lung Cancer with Acquired Resistance to KRASG12C Inhibitors
Authors: Pinnelli Marika , Trusolino Livio 
Published: March 2022

Abstract

Summary:
Inhibitors of KRASG12C that bind the target in its inactive conformation and lock it in off-mode have shown early signs of clinical activity in patients with KRASG12C-mutant lung cancer, but responses tend to be short-lived and invariably prelude the development of acquired resistance through largely unexplored mechanisms. A new study describes the emergence of RAS–MAPK heterogeneous subclonal alterations in a patient relapsed on a KRASG12C inactive-state inhibitor and identifies a novel KRASY96D-resistant variant that is druggable by a next-generation compound capable of associating with KRASG12C in its active configuration.
See related article by Tanaka et al., p. 1913.
Chemerin Tips the Scales in ccRCC to Evade Ferroptosis
Authors: Reznik Ed , Jiang Hui , Hakimi A. Ari 
Published: March 2022

Abstract

Summary:
Obesity is both a risk factor for the development of the most common form of kidney cancer, clear cell renal cell carcinoma (ccRCC), and a prognostically protective factor for clinical outcomes. In this issue of Cancer Discovery, Tan and colleagues identify the tumor- and adipose-derived adipokine chemerin as a circulating mediator of ccRCC lipid metabolism and ferroptotic susceptibility that may clarify the paradoxical relationship between ccRCC and obesity.
See related article by Tan et al., p. 2072.
Association Between Atrial Fibrillation and Occupational Exposure in Firefighters Based on Self‐Reported Survey Data
Authors: Vanchiere Catherine , Thirumal Rithika , Hendrani Aditya , Dherange Parinita , Bennett Angela , Shi Runhua , Gopinathannair Rakesh , Olshansky Brian , Smith Denise L. , Dominic Paari 
Published: March 2022

Background
Exposure to inhaled smoke, pollutants, volatile organic compounds, and polycyclic aromatic hydrocarbons in the firefighting environment has been associated with detrimental respiratory and cardiovascular effects, making firefighters a unique population with both personal and occupational risk factors for cardiovascular disease. Some of these exposures are also associated with development of atrial fibrillation. We aimed to study the association of atrial fibrillation and occupational exposure in firefighters.

Methods and Results

A cross‐sectional survey was conducted between October 2018 and December 2019. Data were gathered electronically and stored in a secure REDCap database through Louisiana State University Health Shreveport. Firefighters who were members of at least 1 of 5 preselected professional organizations were surveyed via electronic links distributed by the organizations. The survey queried the number of fires fought per year as a measure of occupational exposure, as well as self‐reported cardiovascular disease. A total of 10 860 active firefighters completed the survey, of whom 93.5% were men and 95.5% were aged ≤60 years. Firefighters who fought a higher number of fires per year had a significantly higher prevalence of atrial fibrillation (0–5 fires per year 2%, 6–10 fires per year 2.3%, 11–20 fires per year 2.7%, 21–30 fires per year 3%, 31 or more fires per year 4.5%;
P
<0.001). Multivariable logistic regression showed that a higher number of fires fought per year was associated with an increased risk of atrial fibrillation (odds ratio 1.14 [95% CI, 1.04–1.25];
P
=0.006).

Conclusions
Firefighters may have an increased risk of atrial fibrillation associated with the number of fires they fight per year. Further clinical and translational studies are needed to explore causation and mechanisms.
The Challenge of Christian Deliberation in a Libertarian Context
Authors: Glenna Leland L. , Stofferahn Curtis W. 
Published: March 2022

Abstract
In 2005, the Evangelical Lutheran Church in America’s (ELCA) Churchwide Assembly authorized the formation of a task force to prepare a social statement on genetics and faith. Although the Churchwide Assembly voted to adopt the social statement in August of 2011 by a wide margin, there had been an earlier controversy. In June 2010, an article in the Dakota Farmer questioned whether the ELCA was accusing farmers of “sin” for planting genetically engineered crop seeds. At least two churches in rural North Dakota cited this factor as a reason for leaving the ELCA. Seven synods with strong farmer constituencies proposed resolutions challenging the social statement. This paper explores how the opposition used agrarianism and libertarianism to attack the ELCA’s use of the Christian concept of the common good in the social statement. This case reveals the challenges that the Church faces when contributing to ethical deliberations on controversial issues.
Richard Baxter Conformed to Nonconformity
Authors: Sytsma David S. 
Published: March 2022

Abstract
Through an examination of the Nonconformist reception of Richard Baxter, this essay provides a window into theological transition within early modern Protestantism. I argue that, although Baxter excelled in knowledge of scholastic theology, integrated scholastic theology into his practical writings, and produced a great scholastic system of theology—the Methodus Theologiae Christianae (1681)—over the course of the eighteenth and nineteenth centuries, scholastic and philosophical aspects within Baxter’s corpus were ignored, downplayed, and even excised by Nonconformists who otherwise strongly sympathized with his writings. The modern focus on Baxter’s practical works and neglect of Baxter’s scholastic theology is due in large part to this later reception. The story of Baxter’s reception is, moreover, illustrative of a general shift in philosophical and theological orientation in late seventeenth- and eighteenth-century Nonconformity.
Religious Belonging and Multinational Encounters in “Infidel Izmir”
Authors: Hazir Ediz 
Published: March 2022

Abstract
In Turkey, the Roman Catholic Church faces an uncertain future as it lacks official recognition of its legal status. Thus, the survival of the small parishes signifies the survival of the Catholic Church in contemporary Turkey. This article focuses on the perseverance of the multicultural Roman Catholic community of Our Lady of Lourdes (Notre Dame de Lourdes) of Göztepe (in Izmir) after the arrival of Father Gabriel Ferone in 2008. The revival of Our Lady of Lourdes resulted from people of different backgrounds (i.e., Europeans, African students, Turks) moving to Izmir and joining this parish. The paper also explores the change in the demography of the parish during its transformation throughout the years.
Mysticism and Theosophy in the Service of the Regime: Azharite Scholars and the Challenges to Religion-State Relations under Mubarak
Authors: Machlis Elisheva 
Published: March 2022

Abstract
Challenged by Salafi Islam, Sufism managed to reassert itself in Egypt by acquiring new roles in society while emphasizing commitment to the Sharia. This article explores the role played by the religious organs of the state in promoting Sufism under President Hosni Mubarak, in the context of growing challenges to religion-state relations during this period. Focusing on the thought of ʿAlī Jumʿa, the Grand Mufti of Egypt (2003–2013), and the current Shaykh al-Azhar Aḥmad Muḥammad Aḥmad al-Ṭayyib, it also assesses the contribution of popular preachers, many of whom were graduates of al-Azhar, to this mystical discourse. The study aims to demonstrate that these popular preachers shared with the Azharite scholar some form of identification with theoretical mysticism, reflecting a broad inclination towards Sufism within Egyptian society.
The Shaykh al-Azhar and the Grand Mufti sought to prove the compatibility between spirituality with its esoteric and introspective basis and Islamic law with its more worldly and structured dimension, by incorporating a theosophical debate within an apologetic exchange with Western thought. While this encounter with mysticism did not represent a new phenomenon, the novelty was in its political direction, in which a Sufi-oriented worldview became a tool to strengthen the regime’s position in its struggle against Islamist movements. The regime’s growing dependence on its religious institutions to counter the challenge of political Islam enhanced the bargaining-position of al-Azhar and Dār al-Iftāʾ, providing them leverage to advance the path of Islam and mitigate the regime’s secular orientation. While many popular preachers backed moderate Islamism, the religious officials of al-Azhar and Dār al-Iftāʾ relied on mysticism to support a highly supervised state-sponsored Islam. The reliance on the spiritual path to support diverse political trends demonstrates the all-encompassing and dynamic nature of theoretical mysticism as it was infused with rationalism, new knowledge, politics and a Sharia-based worldview.
On the History of Sufism in Australia: A Manuscript from the Broken Hill Mosque
Authors: Cook Abu Bakr Sirajuddin , Dawood Rami 
Published: March 2022

Abstract
As scholarly interest in Australia’s cameleers has increased, there has been suggestions that some of these Muslim migrants were connected with Sufism. However, to date, there has been limited analysis and insufficient evidence to claim a strong connection between the cameleers and Sufism in Australia. This article attempts to rectify this by providing an analysis and translation of a handwritten manuscript found at Broken Hill’s historic cameleer mosque. The contents of this manuscript highlight a strong connection to the history of Sufism, tracing separate family and pedagogic genealogies back to ʿAbd al-Qādir al-Jīlānī (d. 561/1166), the founder of the Qādiriyya Sufi order.
The Eleatic Palamedes: Zeno’s Defence of the Eleatic Doctrine of the One-All in the Phaedrus
Authors: Ferro Francesco 
Published: March 2022

Abstract
The aim of this paper is to make good philosophical sense of Plato’s portrayal of Zeno in the Phaedrus, both in itself and in the light of the characterization emerging from the Parmenides, where Plato describes Zeno as a faithful defender of the doctrine of the One-All professed by his teacher Parmenides. Therefore, starting from the example of the Parmenides, I will demonstrate that, from Plato’s point of view, the pairs of opposites that characterize Zeno’s arguments in the Phaedrus do not constitute contrasting positions that the Eleatic thinker adopted at different times, but contradictory consequences deriving from the admission of multiplicity. Finally, this will allow us to truly understand both the reason why in the Phaedrus Zeno is counted among those who practice the ἀντιλογικὴ τέχνη and the sarcasm that Plato expresses through the epithet Palamedes.
Philosopher, choisir sa vie. Du mythe d’Er à la prohairesis d’Épictète
Authors: Bourbon Marion 
Published: March 2022

Abstract
This paper aims to shed light on Plato’s myth of Er contribution to the emergence of a conception of choice as a principle of identity. Our hypothesis is that this myth brings out what is a real choice and that only philosophy enable us to make it. Philosophy as a way of life is that according to it our choice of life become a free choice and a principle of identity — because this first choice determines all the others in the entire life. From this view, I propose to assign Cicero’s voluntas and Epictetus’s prohairesis — as faculty of choice and principle of personal identity — to this point of the myth : philosophy appears as the way to make the choice to choose. In this regard, we are our choices.
Java–Sumatra Niño/Niña and Its Impact on Regional Rainfall Variability
Authors: Lee Sang-Ki , Lopez Hosmay , Foltz Gregory R. , Lim Eun-Pa , Kim Dongmin , Larson Sarah M. , Pujiana Kandaga , Volkov Denis L. , Chakravorty Soumi , Gomez Fabian A. 
Published: March 2022

Abstract
A phenomenon referred to here as Java–Sumatra Niño/Niña (JSN or JS Niño/Niña) is characterized by the appearance of warm/cold sea surface temperature anomalies (SSTAs) in the coastal upwelling region off Java–Sumatra in the southeastern equatorial Indian Ocean. JSN develops in July–September and sometimes as a precursor to the Indian Ocean dipole, but often without corresponding SSTAs in the western equatorial Indian Ocean. Although its spatiotemporal evolution varies considerably between individual events, JSN is essentially an intrinsic mode of variability driven by local atmosphere–ocean positive feedback, and thus does not rely on remote forcing from the Pacific for its emergence. JSN is an important driver of climate variability over the tropical Indian Ocean and the surrounding continents. Notably, JS Niña events developing in July–September project onto the South and Southeast Asian summer monsoons, increasing the probability of heavy rainfall and flooding across the most heavily populated regions of the world.
Management of Blunt Traumatic Abdominal Wall Hernias: An Analysis of the National Trauma Data Bank
Authors: Paul Manika , Kondal Bhani , Napatkamon Ayutyanont , Sheets Nicholas , Mahmoud Ahmed , Plurad David 
Published: March 2022

Background Blunt traumatic abdominal wall hernias (TAWH) are uncommon injuries with variable presentation and unstandardized management. Few national systematic descriptive studies have been conducted about TAWH. We present a retrospective descriptive study utilizing the National Trauma Data Bank (NTDB) to better characterize risk factors associated with TAWH and management practices. Methods The NTDB (years 2016-2019) was examined for adult blunt trauma patients who had TAWH. Data included demographics, trauma-specific variables, management strategies, and outcome measures. Descriptive statistics were performed by univariate analysis. Results 2 871 367 adult blunt trauma patients were identified in the NTDB dataset. 206 had abdominal wall hernias (<.01%). Compared with the overall blunt trauma cohort, patients with TAWH had higher body mass index (BMI) and Injury Severity Scores (ISS), were more likely to be male, and had a higher mortality rate. 44 patients (21%) underwent operative management during their initial admission. Surgically managed patients were younger, had higher ISS and BMI, and were more likely to have concomitant intra-abdominal injuries. The few patients who had laparoscopic surgery had significantly higher BMI. Patients managed operatively had longer hospital and ICU lengths of stay and increased incidence of medical complications. Conclusions TAWH is an uncommon complication of blunt abdominal trauma, associated with higher BMI, ISS, and increased mortality. Initial operative management was pursued in 21% of cases, more often in younger, more severely injured patients with other intra-abdominal injuries. Evidence-based guidelines, based on multicenter prospective studies with longer follow-up, should be developed for management of these unique injuries.
One-shot cardioplegia for minimally invasive mitral valve repair-a comparison of del Nido and Bretschneider Histidine-Tryptophan-Ketoglutarate solutions
Authors: Gerber Witold , Sanetra Krzysztof , Gerber Agnieszka Drzewiecka- , Jankowska-Sanetra Justyna , Kuczera Małgorzata , Białek Krzysztof , Buszman Piotr Paweł , Bochenek Andrzej 
Published: March 2022

Background Minimally invasive procedures are demanding in terms of cardioprotection. In many leading centres Bretschneider HTK solution is used for mitral valve surgery. The study was designed to provide comparison of the del Nido and Bretschneider HTK protocol. Methods Patients who underwent minimally invasive mitral valve repair for primary mitral regurgitation and received single delivery of either del Nido (Group 1) or Bretschneider HTK cardioplegia (Group 2) were matched on basis of age, gender and length of the cross-clamp time. The groups were compared in terms of major adverse cardiac and cerebrovascular events (death, myocardial infarction, stroke), high sensitivity troponin T (hs-TnT) and creatine kinase- MB isoenzyme (CK-MB) release at 12 h and 24 h following the surgery, incidence of low cardiac output syndrome (LCOS), postoperative arrhythmia, transfusions and postoperative renal function. Results Case control matching selected 38 pairs of patients. None of patients died, nor suffered from myocardial infarction or stroke. Troponin values did not differ at 12 h (median: 281.0 pg/mL vs 313.0 pg/mL; p = .38) and 24 h (median: 261.0 pg/mL vs 299.0 pg/mL; p = .54), as well as CK-MB at 12 h (median: 25.0 ng/mL vs 29.0 ng/mL; p = .31) and 24 h (median: 11.0 ng/mL versus 9.6 ng/mL; p = .46). Difference in occurrence of LCOS was insignificant (2 vs 7; 5.2% vs 18.4%; p =.15). No difference was shown in incidence of postoperative arrhythmia, transfusions and renal function. Conclusions Del Nido cardioplegia can be used safely as an alternative for Bretschneider HTK for minimally invasive mitral valve surgery.
Investigation and multi-objective optimization of monocrystalline silicon wafering using wire electro-discharge machining
Authors: Verma Anmol S , Singh Shankar 
Published: March 2022

Monocrystalline silicon wafers are widely used as the primary material for solar cell production in the photovoltaic industry, owing to their high efficiency and sleeker aesthetic. Wafering is the primary process towards wafer production. The existing wafering processes have limitations of cracking, chipping, and high kerf loss, arising the need for cost-efficient and precise methods to produce wafers. In the present experimental work, an attempt has been made to explore the potential of Wire Electro-discharge Machining (WEDM) for wafer production and to gain an understanding of the effects caused by pulse on time (Ton), pulse off time (Toff), peak current (Ip), wire tension (WT), and wire feed rate (WFR) during the wafering process to achieve the optimal parametric setting for attaining maximum wafering speed and minimum surface roughness. The work material used was P-type monocrystalline silicon. Wafers thickness of 250 μm was produced, avoiding edge chipping. The experimentation was planned according to the face-centered central composite design. The obtained results were statistically analyzed, and response surface methodology (RSM) was used to model the wafering speed and surface roughness. From the analysis of experimental results, it was noticed that at the higher level of Ton and Ip, a maximum wafering speed of 2.574 mm/min was attained. In contrast, the minimum surface roughness of 1.57 μm was achieved at the lower level of Ton and Ip. The most significant process variables that influence the wafering speed and surface roughness are the Ton, Toff, and Ip. Micrographs of the wafer surface reveal the presence of micro craters, but there was no evidence of micro-cracks. The multi-objective optimization of the responses was done using the desirability approach, and the optimized values of wafering speed and surface roughness attained were 0.989 mm/min and 1.57 μm, respectively.