bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of Oxidative Stress in Acute Poisoning in Central India
Authors: Yembarwar Nagendra Kishanprasad , Guddetwar Sanjay G 
Published: March 2022

Background: Tissue inflammation, low food intake of micronutrients due to sleepiness, free radical burst from activated macrophages, and excessive medication cause oxidative stress in acute poisoning. If not neutralised by antioxidants, these free radicals may contribute to tissue inflammation. The word oxidative stress refers to a scenario in which free radical generation and antioxidant defence are out of balance. In humans, oxidative stress is caused by a reduction in bodily antioxidants when free radical generation exceeds endogenous antioxidant levels, resulting in significant cell damage/death.
Free radicals may destroy all major macromolecules, including lipids, proteins, and nucleic acids, but lipids are the most vulnerable.
Aim: To evaluate antioxidant status in acute amitriptyline poisoning (AP) cases undergoing routine standard treatment (RST) after supplementation with Vitamin C and alpha lipoic acid either alone or in combination, and compare it with that of normal healthy volunteers.
Material and Method: A total of 150 people were enrolled in the study, and they were split into five groups. They came from the IMCU and the Toxicology Ward. The consent of the patients' attendants was sought. The patients were chosen at random. To classify the level or grade of coma in poisoned individuals, the Edinburgh scale was utilized. At the time of admission and discharge, the levels of plasma cholinesterase, SOD, catalase, Glut-peroxidase, Glutathione transferase, MDA, Total-Antioxidant, LDH, and CK were measured.
Results: This study offers quantifiable recommendations for vitamin C and alpha lipoic acid intake to aid in rapid recovery and glutathione antioxidant status. On supplementation with vitamin C and alpha lipoic acid, we detected a significant decrease in catalase activity in all groups of acute Amitriptyline poisoning cases. For Gr. V (acute Amitriptyline poisoning cases), we found reduced glutathione activity on admission and higher values on discharge. In light of the preceding discussion, it is worth noting that the higher LDH and CPK in groups that may be attributable to pulmonary infarction rather than cardiac or skeletal muscle involvement could be due to pulmonary infarction.
Conclusion: Supplementation with vitamin C and alpha lipoic acid improved antioxidant levels during therapy. We propose that the antioxidant level of acute amitriptyline poisoning cases be examined for more successful recovery, and that diets poor in antioxidants may cause recovery to be sluggish. Oral supplementation, in our opinion, will be more successful for chronic Amitriptyline poisoning patients for a longer period of time, while IV form of vitamin C and alpha lipoic acid will be more effective for acute Amitriptyline poisoning instances.
Keywords: Amitriptyline, MDA, Total-Antioxidant, LDH, CK, SOD, AP, RST.
Pre-operative MRI Findings in Idiopathic Intracranial Hypertension (IIH) Patients Who Underwent Optic Nerve Sheath Fenestration (ONSF) with Postoperative Visual Improvement: Observational Findings
Authors: Chowdhury Forhad Hossain , Rahman Muhammad Mukhlesur , Haque Mohammod Raziul , Sarker Mainul Haque 
Published: March 2022

Background: Optic nerve sheath fenestration (ONSF) is commonly used in idiopathic intracranial hypertension (IIH) with visual deterioration and visual improvement is observed post operatively in these patients.
Objective: Retrospective evaluation of MRI observations in IIH patients who underwent optic nerve sheath fenestration (ONSF) with postoperative visual improvement.
Materials and method: Optic nerve sheath fenestration (ONSF) was done in twenty four (24) patients with IIH having severe visual impairment. Post operatively all patients improved in their visual functions. The recorded pre operative MRI (of brain and orbit) of patients were reviewed and evaluated retrospectively.
Results: Total number of MRI studied was 24. Male female ratio was 1:11. Posterior globe flattening was found in all 24 (100%) cases. Other findings were horizontal tortuosity of optic nerve (92%), optic nerve head protrusion (87.5%), optic nerve sheath distension (87%), and vertical buckling (62.5%). Ventricular size was normal in 92% cases and slit ventricle was found only in 8% cases. On magnetic resonance venogram (MRV) one sided transverse sinus abnormality was found in 25% cases. There was empty sella in 79% cases, more marked in three cases.
Conclusion: The MRI findings in IIH patients with positive post ONSF result are of variable degree and prevalence except posterior globe flattening which was found in all cases.
Delta Med Col J. Jul 2020 8(1): 21-27
Analisis Daya Saing Pengembangan Lembaga Pendidikan Di Sdi Al-Huda Kota Kediri
Authors: Nasikhah Khafidhotun , Zaenul Fitri Agus 
Published: March 2022

This study aims to determine the management strategy used in the development of SDI Al Huda, Kediri City. Al Huda can experience fairly rapid development in the last 2 periods by implementing total quality management. This is based on the strength of the team work to carry out continuous renewal by improving the quality of service both from the internal and external side of the institution. This is evidenced by the fact that in the last 2 periods, Al Huda has been increasing the number of extracurricular activities offered to the community, excelling, having quotas that have increased even beyond capacity, and starting this year, they have been given the mandate to become a driving school. Researchers used qualitative research and phenomenological approaches. The finding of the success of Al-Huda's development competitiveness is by implementing strategic management by reviewing 2 sides, namely internally and externally of the institution, with the application of TQM. The target of the quality of institutional services in the competitiveness of institutional development through two sides, namely: first, internally in the form of: a.) Quality system within the institution by implementing quality assurance; b.) Quality services between education personnel in schools; c.) Quality services between teachers and students; second, externally in the form of: a.) Quality services between schools and parents; b.) Quality service between school and community.
[Penelitian ini bertujuan untuk mengetahui manajemen strategik yang digunakan dalam pengembangan di SDI Al Huda Kota Kediri. Al Huda mengalami perkembangan cukup pesat dalam 2 periode terakhir dengan menerapkan total quality management dengan dilandasi kuatnya team work bagian dari kekuatan internal untuk melakukan pembaharuan dan meningkatkan kualitas mutu layanan. Hal tersebut dibuktikan dalam penambahan beberapa kegiatan ekstrakurikuler, pencapaian prestasi, penerimaan peserta didik yang senantiasa meningkat hingga melebihi kapasitas, dan tahun 2022 diberi amanah menjadi sekolah penggerak. Penelitian ini menggunakan jenis penelitian kualitatif dan pendekatan fenomenologi. Temuan keberhasilan daya saing pengembangan Al-Huda yakni dengan menerapkan managemen strategik dengan meninjau 2 sisi, yakni secara internal dan eksternal lembaga, dengan penerapan TQM. Sasaran mutu layanan lembaga dalam daya saing pengembangan lembaga melalui dua sisi, yakni: pertama, secara internal berupa: a.) Sistem mutu dalam lembaga dengan menerapkan penjaminan mutu; b.) Layanan mutu antara tenaga kependidikan di sekolah; c.) Layanan mutu antara guru dan peserta didik; kedua, secara eksternal berupa: a.) Layanan mutu antara sekolah dan orangtua; b.) Layanan mutu antara sekolah dan masyarakat]
DESIGN AND IMPLEMENTATION OF INVENTORY INFORMATION SYSTEM IN PUTRA MARIYO TRADING BUSINESS
Authors: Harisnur Alvian , Gunawan Dedi 
Published: March 2022

Technological advancement in information technology applications allows the data recording process to become easier. Putra Mariyo Trading Business is a business institution that sells wood as a building material in various types and sizes. Data processing of incoming and outgoing goods in this business is performed only by writing goods data into a specific book. Consequently, some problems such as the loss of data and miss calculation in processing transactions usually occur. Therefore, in this research, we design a system to address the problems. The system is developed by following the Waterfall software development method. To build the system, we opt to use PHP programming language, CodeIgniter framework, and MySQL as the database server. To determine system reliability, this information system testing uses black box testing which focuses on the functional requirements of the system. To evaluate the performance of the system two testing steps i.e., black-box testing and System Usability Scales (SUS) are adopted. Black-box testing results show that the error percentage of our system is 0%. The SUS testing is conducted to obtain responses from users and the SUS score obtained is 70.1 indicating that the system is at the "good" level and reliable to use.
Efektivitas Intervensi Ultrasound (US) dan Stretching Exercise untuk Meningkatkan Kemampuan Fungsional Tangan pada Pasien Carpal Tunnel Syndrome di RSUD Mandau Duri
Authors: Muawanah Siti , Yulianti Ranika , Ismaningsih Ismaningsih 
Published: March 2022

Carpal Tunnel syndrome (CTS) merupakan syndrome penjepitan saraf dengan bentuk cedera tekanan berulang pada nervus medianus akibat dari aktivitas yang terus menerus dan penggunaan tangan yang secara intensif seperti menggenggam, memutar, atau menekuk. Aktivitas tersebut akan memperparah keadaan dan menimbulkan keluhan berupa nyeri dan kesemutan diantaranya jari-jari tangan I sampai setengah jari IV bagian telapak tangan, numbness, nyeri, dan kelemahan otot sehingga menyebabkan penurunan aktifitas kemampuan Fungsional Tangan. . Tujuan Penelitian ini untuk Mendeskripsikan Efektivitas intervensi Ultrasound (Us) Dan Stretching Exercise Untuk Meningkatkan kemampuan Fungsional Tangan Pada Pasien Carpal Tunnel Syndrome Di Rsud Mandau Duri. Metode penelitian ini adalah Eksperimental murni dengan randomized pre-test and post- test group design. Sampel penelitian pasien Poli Fisioterapi Rumah Sakit Mandau 13 pasien dalam I kelompok diberi ultrasound (Us) Dan Stretching Exercises sebanyak 6 kali selama 2 minggu. Dilakukan pemeriksaan spesifik fisioterapi dengan phalen’s test dan pengukuran dengan wrist-hand disability index (WHDI). Hasil uji menunjukkan terjadi peningkatan aktivitas fungsional tangan dengan intervensi ultrasound (US) dan stretching exercise sebelum dan sesudah pada satu kelompok dengan uji normalitas dengan shapiro-wilk test dengan nilai sebelum P = 0,074 (P>0,05) dengan nilai rerata 44.62±10.50 dan nilai sesudah P = 0,015 (P>0,05) dengan rerata 17.69±7.25 maka nilai normalitas data berdistribusi normal jadi Uji hipotesis penelitian menggunakan uji t berpasangan (paired samples test) dengan hasil yang signifikan P = 0,000 (P<0,05) dengan nilai rerata 26.92±15.48. Kesimpulan hal tersebut bermakna sehingga dapat disimpulkan pemberian ultrasoud dan stretching exercises pada pergelangan tangan dapat meningkatkan kemampuan fungsional tangan pada pasien carpal tunnel syndrome di RSUD Mandau Duri.
SELEKSI PROSES EKSTRAKSI DAUN SIRIH PADA PRA RANCANGAN PABRIK HAND SANITIZER DAUN SIRIH DENGAN KAPASITAS PRODUKSI 480 TON/TAHUN
Authors: Yulinar Farah , Suharti Profiyanti Hermien 
Published: March 2022

Penggunaan hand sanitizer oleh masyarakat di era pandemi Covid-19 semakin meningkat sebagai salah satu protokol Covid-19 pengganti cuci tangan. Zat antiseptik yang ada pada kandungan Hand sanitizer membantu mengatasi berbagai virus yang menempel pada permukaan tangan yang mempunyai kandungan alkohol dan berwujud gel. Penggunaan alkohol yang terlalu sering akan menyebabkan kulit menjadi kering. Daun sirih hijau memiliki sifat antiseptik karena memiliki minyak atsiri yang mengandung +30% fenol. Tujuan penelitian ini adalah untuk menentukan proses terbaik yang akan digunakan dalam masing-masing tahapan pembuatan hand sanitizer gel tersebut. Tujuan dari seleksi itu sendiri adalah untuk mendapatkan proses yang terbaik dari dua pilihan alternatif proses yang mungkin dari segi teknis dan ekonomis. Seleksi proses ekstraksi daun sirih pada proses pembuatan hand sanitizer ini mencakup serangkaian jenis proses produksi dengan membandingkan penggunaan metode maserasi dan soxhletasi. Soxhletasi adalah teknik ekstraksi secara berkesinambungan dengan alat soxhletasi menggunakan pelarut organik pada suhu didih. Metode soxhletasi dilakukan dengan cara melarutkan sampel dalam pelarut soxhletasi yang telah dipanaskan, sehingga semua komponen yang diinginkan dalam sampel dapat terisolasi dengan sempurna. Proses ekstraksi yang dipilih yaitu metode soxhletasi dengan produk yang dihasilkan berupa minyak atsiri. Waktu proses ekstraksi adalah 4 sampai 6 jam untuk mencapai sirkulasi dengan suhu ekstraksi 60-80°C.
Prognosis Implication of N-Terminal Pro-B-Type Natriuretic Peptide in Adult Patients With Acute Myocarditis
Authors: Zhao Yan , Lyu Naqiang , Zhang Wei , Tan Huiqiong , Jin Qi , Dang Aimin 
Published: March 2022

BackgroundThe aim of this study is to investigate the role of N-terminal pro-B-type natriuretic peptide (NT-proBNP) in assessing the poor outcomes of adult patients with acute myocarditis.MethodsA total of 170 adult patients with available NT-proBNP information were included in the study. They were grouped according to quartiles of NT-proBNP concentrations at admission. Baseline and follow-up information was collected. Thirty-day major adverse cardiac events (MACE) were death and heart transplantation. Long-term MACE included all-cause death, heart transplantation, re-hospitalization due to heart failure, sustained ventricular arrhythmia, and myocarditis relapse.ResultsDuring a median follow-up of 3.8 years, patients in the highest NT-proBNP quartile suffered from the highest risk both of 30-day and long-term MACE (P &lt; 0.001 by log-rank test). Multivariate analysis showed that apart from left ventricular ejection fraction (LVEF), an increased baseline NT-proBNP &gt; 3,549 pg/mL (hazard ratio 3.535, 95% CI 1.316–9.499, P = 0.012) and NT-proBNP &gt; 7,204 pg/mL (hazard ratio 22.261, 95% CI 1.976–250.723, P = 0.012) was independent predictor of long-term and 30-day MACE, respectively.ConclusionsHigher baseline NT-proBNP level was an independent predictor of poor outcomes in adult patients with acute myocarditis. Therefore, NT-proBNP may serve as a useful biomarker for risk stratification in acute myocarditis patients.
Long-Term Efficacy and Anticoagulation Strategy of Left Atrial Appendage Occlusion During Total Thoracoscopic Ablation of Atrial Fibrillation to Prevent Ischemic Stroke
Authors: Kim Ju Youn , Jeong Dong Seop , Park Seung-Jung , Park Kyoung-Min , Kim June Soo , On Young Keun 
Published: March 2022

ObjectivesAtrial fibrillation (AF) is associated with an increased ischemic stroke, and the left atrial appendage (LAA) represents the main source of thrombus formation. We evaluated the long-term efficacy of surgical thoracoscopic LAA occlusion during total thoracoscopic ablation of AF to prevent the stroke and anticoagulation strategy after surgery.MethodsPatients who underwent total thoracoscopic ablation for AF, from February 2012 to May 2020, were included; Patients who did not receive LAA occlusion were excluded. We evaluated the development of thromboembolism in these patients.ResultsThe total number of 460 patients [mean age, 57.1 ± 9.2 years; 400 (87.0%) males] were included in the study. The mean follow-up duration was 44.8 months. The mean CHA2DS2-VASc score was 1.9 ± 1.6. Median OAC duration was 109.5 days after the surgery, and the final number of patients who discontinued OAC were 411 (89.3%) in total. Anticoagulation discontinuation rate according to CHA2DS2-VASc score are as follows; (i) 0 = 99.0%; (ii) 1 = 98.2%; and (iii) ≥2 = 81.3%. The annualized incidence rate of ischemic stroke was 0.78%/year, showing a 73% risk reduction compared with the CHA2DS2-VASc predicted rate without anticoagulation. The hazard ratio for ischemic stroke according to previous stroke history was 1.5 [95% confidential interval (CI) 0.3–7.3, p = 0.62], and that of remnant LAA was 5.1 (1.2–20.9, p = 0.02).ConclusionsThoracoscopic LAA occlusion during total thoracoscopic ablation of AF was effective to prevent ischemic stroke. Most patients could discontinue OAC therapy after the procedure. Patients who had a residual trabeculated LAA, or peri-occluder pouch in follow-up CT need to maintain OAC therapy even after LAA occlusion.
Zircon SHRIMP U-Pb Dating and Significance From Weathered Residual Kaolin Deposits on the Northern Margin of the Qinzhou-Hangzhou Suture Zone, China
Authors: Li Chunhai , Sun Qifa , Sun Zhonglin , Zhou Xiaohua , Zhang Wei , Chen Rong , Gao Tianshan 
Published: March 2022

Weathered residual Kaolin deposits on the northern margin of the Qinzhou-Hangzhou Suture Zone are characterized by more feldspar-containing minerals and fewer dark minerals. These deposits have attracted increasing attention because of their high whiteness, low harmful impurity content, low depth of weathered mineralization, and ease for mining. The ore-forming rock masses mainly include granite (granite porphyry), quartz porphyry, eurite, haplite, and other acidic veins; the ore-bearing walls are mainly of Upper Proterozoic. Previous studies suggested that dyke rocks related to Kaolin deposits in this belt belong to the Mesozoic, but there is a lack of information regarding specific mineralization ages. In this study, two dyke wall-type weathered residual Kaolin deposits were selected from the northern margin of the Qinzhou-Hangzhou Suture Zone (Dongxicun and Yinbeidong, Jiangxi Province, China) for zircon SHRIMP dating. Two zircon U-Pb-based ages were obtained: 843 ± 10 Ma from Dongxicun granite veins that intrude into the Neoproterozoic Jiuling rock masses; 152.3 ± 1.8 Ma for Yinbeidong granite porphyry veins that intrude into the Neoproterozoic Anlelin Formation. We suggest that the dykes related to the Kaolin deposits were formed in the Neoproterozoic and late Jurassic. The Neoproterozoic dyke may be related to the convergence, formation, or pyrolysis of the Rodinia Supercontinent and the late Jurassic dyke may be related to the subduction of the Paleo-Pacific Plate. These results provide a chronological basis for the investigation and evaluation of weathered residual Kaolin deposits on the Qinzhou-Hangzhou Suture Zone.
Reconstruction of Aeolian Activity Variability in the Central Tibetan Plateau From Grain-Size Distributions: End-Member Modeling and Source Attribution of Sediments From Lake Selin Co
Authors: Zhang Chunhui , Zhang Wanyi , Liu Yan , Yao Jinjiao , Wan Renchao , Li Huwei , Hou Xinyu , Zhang Chengjun 
Published: March 2022

The grain size analysis and end-member modeling of clastic fractions in the Selin Co basin sedimentary sequence have been revealing variations of aeolian activity in the central Tibetan Plateau since 3,900 cal yr BP. The grain-size distributions measured in this study were classified into three statistical end-members that may be connected to clastic material inputs from a variety of sources and transport processes. Among these, the EM3 fraction (modal grain size of ∼138 μm) was suggested to indicate the aeolian activity history in the central Tibetan Plateau. The results indicate that the aeolian activity in this region occurred under dry and cold conditions since 3,900 cal yr BP, with three strong aeolian activity intervals at 3,200–2,900 cal yr BP, 2,400–1,400 cal yr BP, and after 130 cal yr BP. Comparison with other records showed that solar insolation, weakening Indian summer monsoon, and the strengthening westerlies have a direct relationship with the aeolian activity in the central Tibetan Plateau. We therefore suggest that the atmospheric circulation patterns and effective humidity may have a strong impact on the water balance and weathering intensity in the arid and semiarid areas, hence affecting dust emissions. Also, the coarse detrital end-member fraction of lake sediments is suggested as a potential aeolian activity proxy.
Network Pharmacological Study on Mechanism of the Therapeutic Effect of Modified Duhuo Jisheng Decoction in Osteoporosis
Authors: Huang Xudong , Zhou Zhou , Zheng Yingyi , Fan Guoshuai , Ni Baihe , Liu Meichen , Zhao Minghua , Zeng Lingfeng , Wang Weiguo 
Published: March 2022

BackgroundModified Duhuo Jisheng Decoction (MDHJSD) is a traditional Chinese medicine prescription for the treatment of osteoporosis (OP), but its mechanism of action has not yet been clarified. This study aims to explore the mechanism of MDHJSD in OP through a combination of network pharmacology analysis and experimental verification.MethodsThe active ingredients and corresponding targets of MDHJSD were acquired from the Traditional Chinese Medicine System Pharmacology (TCMSP) database. OP-related targets were acquired from databases, including Genecards, OMIM, Drugbank, CTD, and PGKB. The key compounds, core targets, major biological processes, and signaling pathways of MDHJSD that improve OP were identified by constructing and analysing the relevant networks. The binding affinities between key compounds and core targets were verified using AutoDock Vina software. A rat model of ovariectomized OP was used for the experimental verification.ResultsA total of 100 chemical constituents, 277 targets, and 4734 OP-related targets of MDHJSD were obtained. Subsequently, five core components and eight core targets were identified in the analysis. Pathway enrichment analysis revealed that overlapping targets were significantly enriched in the tumour necrosis factor-alpha (TNF-α) signaling pathway, an inflammation signaling pathway, which contained six of the eight core targets, including TNF-α, interleukin 6 (IL-6), transcription factor AP-1, mitogen-activated protein kinase 3, RAC-alpha serine/threonine-protein kinase, and caspase-3 (CASP3). Molecular docking analysis revealed close binding of the six core targets of the TNF signaling pathway to the core components. The results of experimental study show that MDHJSD can protect bone loss, inhibit the inflammatory response, and downregulate the expression levels of TNF-α, IL-6, and CASP3 in ovariectomized rats.ConclusionThe mechanism of MDHJSD in the treatment of OP may be related to the regulation of the inflammatory response in the bone tissue.