bluuebunny/crossref_metadata_2025_split huggingface dataset:
KRAS-G12C Mutation in One Real-Life and Three Population-Based Nordic Cohorts of Metastatic Colorectal Cancer
Authors: Osterlund Emerik , Ristimäki Ari , Kytölä Soili , Kuopio Teijo , Heervä Eetu , Muhonen Timo , Halonen Päivi , Kallio Raija , Soveri Leena-Maija , Sundström Jari , Keinänen Mauri , Ålgars Annika , Ristamäki Raija , Sorbye Halfdan , Pfeiffer Per , Nunes Luís , Salminen Tapio , Lamminmäki Annamarja , Mäkinen Markus J. , Sjöblom Tobias , Isoniemi Helena , Glimelius Bengt , Osterlund Pia 
Published: February 2022

BackgroundKRAS mutations, present in over 40% of metastatic colorectal cancer (mCRC), are negative predictive factors for anti-EGFR therapy. Mutations in KRAS-G12C have a cysteine residue for which drugs have been developed. Published data on this specific mutation are conflicting; thus, we studied the frequency and clinical characteristics in a real-world and population-based setting.MethodsPatients from three Nordic population-based cohorts and the real-life RAXO-study were combined. RAS and BRAF tests were performed in routine healthcare, except for one cohort. The dataset consisted of 2,559 patients, of which 1,871 could be accurately classified as KRAS, NRAS, and BRAF-V600E. Demographics, treatments, and outcomes were compared using logistic regression. Overall survival (OS) was estimated with Kaplan–Meier, and differences were compared using Cox regression, adjusted for baseline factors.ResultsThe KRAS-G12C frequency was 2%–4% of all tested in the seven cohorts (mean 3%) and 4%–8% of KRAS mutated tumors in the cohorts (mean 7%). Metastasectomies and ablations were performed more often (38% vs. 28%, p = 0.040), and bevacizumab was added more often (any line 74% vs. 59%, p = 0.007) for patients with KRAS-G12C- vs. other KRAS-mutated tumors, whereas chemotherapy was given to similar proportions. OS did not differ according to KRAS mutation, neither overall (adjusted hazard ratio (HR) 1.03; 95% CI 0.74–1.42, reference KRAS-G12C) nor within treatment groups defined as “systemic chemotherapy, alone or with biologics”, “metastasectomy and/or ablations”, or “best supportive care”, RAS and BRAF wild-type tumors (n = 548) differed similarly to KRAS-G12C, as to other KRAS- or NRAS-mutated (n = 66) tumors.ConclusionsIn these real-life and population-based cohorts, there were no significant differences in patient characteristics and outcomes between patients with KRAS-G12C tumors and those with other KRAS mutations. This contrasts with the results of most previous studies claiming differences in many aspects, often with worse outcomes for those with a KRAS-G12C mutation, although not consistent. When specific drugs are developed, as for this mutation, differences in outcome will hopefully emerge.
Decreasing Shortest Path Length of the Sensorimotor Network Induces Frontal Glioma-Related Epilepsy
Authors: Fang Shengyu , Li Lianwang , Weng Shimeng , Guo Yuhao , Zhang Zhong , Wang Lei , Fan Xing , Wang Yinyan , Jiang Tao 
Published: February 2022

BackgroundGlioma-related epilepsy (GRE) is a common symptom in patients with prefrontal glioma. Epilepsy onset is associated with functional network alterations. This study investigated alterations of functional networks in patients with prefrontal glioma and GRE.MethodsSixty-five patients with prefrontal lobe gliomas were retrospectively assessed and classified into GRE and non-GRE groups. Additionally, 25 healthy participants were enrolled after matching for general information. Imaging data were acquired within 72 h in pre-operation. The sensorimotor network was used to delineate alterations in functional connectivity (FC) and topological properties. One-way analysis of variance and post-hoc analysis with Bonferroni correction were used to calculate differences of FC and topological properties.ResultsAll significant alterations were solely found in the sensorimotor network. Irrespective of gliomas located in the left or right prefrontal lobes, the edge between medial Brodmann area 6 and caudal ventrolateral Brodmann area 6 decreased FC in the GRE group compared with the non-GRE group [p &lt; 0.0001 (left glioma), p = 0.0002 (right glioma)]. Moreover, the shortest path length decrease was found in the GRE group compared with the non-GRE group [p = 0.0292 (left glioma) and p = 0.0129 (right glioma)].ConclusionsThe reduction of FC between the medial BA 6 (supplementary motor area) and caudal ventrolateral BA 6 in the ipsilateral hemisphere and the shortening of the path length of the sensorimotor network were characteristics alterations in patients with GRE onset. These findings fill in the gap which is the relationship between GRE onset and the alterations of functional networks in patients with prefrontal glioma.Significance StatementGlioma related epilepsy is the most common symptom of prefrontal glioma. It is important to identify characteristic alterations in functional networks in patients with GRE. We found that all significant alterations occurred in the sensorimotor network. Moreover, a decreased FC in the supplementary motor area and a shortening of the path’s length are additional characteristics of glioma-related epilepsy. We believe that our findings indicate new directions of research that will contribute to future investigations of glioma-related epilepsy onset.
Trends in Staging, Treatment, and Survival in Colorectal Cancer Between 1990 and 2014 in the Rotterdam Study
Authors: Lavrijssen Birgit D. A. , Ruiter Rikje , Fest Jesse , Ikram Mohammad A. , Stricker Bruno H. , van Eijck Casper H. J. 
Published: February 2022

BackgroundThis study aims to assess trends in patient-related factors and treatment strategies in Dutch colorectal cancer (CRC) patients and their effect on survival.MethodsData were obtained from the Rotterdam study, an ongoing population-based study of individuals aged ≥45 years. Between 1990 and 2014, incident, pathology-confirmed CRC cases were divided into two groups based on date of diagnosis (either before or after January 1, 2003). Patient characteristics, initial treatment, and date of mortality were collected. Analyses were performed using Kaplan–Meier and Cox proportional hazard models.ResultsOf 14,928 individuals, 272 developed colon cancer and 124 rectal cancer. Median follow-up was 13.2 years. Patients diagnosed after January 1, 2003 were treated chemotherapeutically more often than those diagnosed prior to this date in colon cancer (28.6% vs. 9.1%, p = 0.02) and treated more often with chemotherapy (38.6% vs. 12.3%, p = 0.02) and radiotherapy (41.3% vs. 10.2%, p = 0.001) in rectal cancer. Overall survival, adjusted for patient, tumor characteristics, and treatment, improved in rectal cancer (HR, 0.31; 95% CI, 0.13–0.74) but remained stable in colon cancer (HR, 1.28; 95% CI, 0.84–1.95).ConclusionChemotherapeutic agents and radiotherapy are increasingly used in CRC patients. Survival in rectal cancer improved, whereas in colon cancer this was not observed.
Salvia miltiorrhiza-Containing Chinese Herbal Medicine Combined With GnRH Agonist for Postoperative Treatment of Endometriosis: A Systematic Review and meta-Analysis
Authors: Gao Qiang , Shen Lei , Jiang Bei , Luan Yi-feng , Lin Li-na , Meng Fan-ci , Wang Chao-ying , Cong Hui-fang 
Published: February 2022

Background: Endometriosis is an estrogen-dependent gynecological inflammatory condition that may lead to infertility and recurrent pelvic pain. The purpose of this research was to determine the efficacy and safety of Salvia miltiorrhiza-containing Chinese herbal medicine (CHM) combined with gonadotropin-releasing hormone agonist (GnRH-a) for postoperative endometriosis management.Methods:Eight databases were systematically searched before October 2021, including PubMed, Embase, Cochrane Library, Scopus, Web of Sceince, CNKI, VIP, and Wanfang. Finally, all randomized controlled studies comparing Salvia miltiorrhiza-containing CHM paired with GnRH-a to GnRH-a alone for postoperative endometriosis management were included.Results: A total of 10 trials involving 836 patients were reported and analyzed. Compared with the control group, the Salvia miltiorrhiza-containing CHM combined with GnRH-a group showed significant superiority in decreasing endometriosis recurrence (risk ratio [RR] = 0.26; 95% confidence intervals [CI]: 0.16–0.41) and increasing the pregnancy rate ([RR] = 1.96; 95% CI: 1.58–2.44). Similarly, the effect of the Salvia miltiorrhiza-containing CHM combined with GnRH-a on CA-125 serum levels was positive (standardized mean difference [SMD] = -0.79; 95% CI: −1.11 to −0.47). Furthermore, this group showed a significant reduction in adverse effects.Conclusion: The results indicate that Salvia miltiorrhiza-containing CHM may be a viable choice for postoperative endometriosis therapy, with the potential to enhance pregnancy while decreasing recurrence and adverse effects.
Cross-Cultural Adaptation and Psychometric Evaluation of the Perceived Ability to Cope With Trauma Scale in Portuguese Patients With Breast Cancer
Authors: Lemos Raquel , Costa Beatriz , Frasquilho Diana , Almeida Sílvia , Sousa Berta , Oliveira-Maia Albino J. 
Published: February 2022

BackgroundThe impact of a cancer diagnosis may be traumatic, depending on the psychological resources used by patients. Appropriate coping strategies are related to better adaptation to the disease, with coping flexibility, corresponding to the ability to replace ineffective coping strategies, demonstrated to be highly related with self-efficacy to handle trauma. The Perceived Ability to Cope with Trauma (PACT) scale is a self-rated questionnaire that assesses the perceived ability to cope with potentially traumatic events, providing a measure of coping flexibility. The current study aimed at examining the psychometric properties of the PACT Scale in Portuguese patients with breast cancer.MethodsThe study included 172 patients recently diagnosed with early breast cancer. Participants completed a Portuguese version of the PACT scale, and instruments of self-efficacy for coping with cancer (Cancer Behavior Inventory-Brief Version—CBI-B), of quality of life (European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core-30—QLQ-C30), and of psychological distress (Hospital Anxiety and Depression Scale—HADS) that were used as convergent and divergent measures, thus assessing construct validity. A confirmatory factor analysis (CFA) was performed to test the factor structure of the Portuguese version of PACT scale and reliabilities were examined.ResultsResults from the CFA confirmed the two-factor structure, consistent with the original Forward and Trauma focus subscales. The two subscales demonstrated high internal consistencies. Convergent and divergent validities were confirmed: the PACT scale was related to high self-efficacy to cope with cancer (CBI-B), to high perceived quality of life (QLQ-C30), and to low psychological distress (HADS).DiscussionOverall, the current results support and replicate the psychometric properties of the PACT scale. The scale was found to be a valid and reliable self-reported measure to assess Portuguese breast cancer patients regarding beliefs about their capabilities in managing the potentially traumatic sequelae of cancer. The PACT is a simple and brief measure of coping flexibility to trauma, with potential relevance for application in clinical and research settings.
Lifestyle advice for hypertension or diabetes: trend analysis from 2002 to 2017 in England
Authors: Henry John A , Jebb Susan A , Aveyard Paul , Garriga Cesar , Hippisley-Cox Julia , Piernas Carmen 
Published: February 2022

BackgroundGuidelines recommend that GPs give patients lifestyle advice to manage hypertension and diabetes. Increasing evidence shows that this is an effective and practical treatment for these conditions, but it is unclear whether GPs offer this support.AimTo investigate trends in the percentage of patients with hypertension/diabetes receiving lifestyle advice versus medication.Design and settingThis was a trend analysis of self-reported data from the annual Health Survey for England (HSE) (2003–2017) and GP-recorded data from the QResearch database (2002–2016).MethodThe percentage of patients with hypertension or diabetes who received lifestyle advice or medication was calculated in each year. Associations between likelihood of receiving lifestyle advice and characteristics were assessed using multivariable logistic regression.ResultsThe percentage of patients receiving lifestyle advice was consistently lower than those receiving medication in both self-reported and medical records. There was consistent evidence of increasing trends in the percentage of patients with hypertension receiving lifestyle advice (HSE 13.8% to 20.1%; Ptrend<0.001; QResearch 11.0% to 22.7%; Ptrend<0.001). For diabetes, there was a non-significant decline in self-reported receipt of lifestyle advice (45.0% to 27.9%; Ptrend = 0.111) and a significant increase in medically recorded delivery of this advice (20.7% to 40.5%; Ptrend<0.001). Patients with hypertension who were overweight or obese were more likely to receive lifestyle advice than those of a healthy weight, whereas the opposite was true for diabetes.ConclusionOnly a minority of patients with diabetes or hypertension report receiving lifestyle advice or have this recorded in their medical records. Interventions beyond guidelines are needed to increase the delivery of behavioural interventions to treat these conditions.
Editorial Edición N°10
Authors: Cátedra Paralela Consejo Editorial 
Published: February 2022

Con gran orgullo estamos celebrando la aparición del número 10 de nuestra Revista. Desde el año 2005 nuestra intención ha sido con- tribuir a gestar un espacio público de debate que nos permita crecer como colectivo profesional, sometiendo los saberes y las prácticas del Trabajo Social a un constante ejercicio de revisión crítica, esto es, una reflexión crítica y consciente sobre lo que se hace y lo que se dice en torno a las problemáticas en las cuales interviene nuestra profesión.
Estamos celebrando y por ello es esta una edición de lujo, en la que tenemos la satisfacción de presentar un Dossier de artículos es- peciales de autoría de prestigiosos/as docentes e investigadores/as de nuestra casa de estudios y de otras unidades académicas del país.
Estamos celebrando diez años de construcción colectiva, de traba- jo arduo y comprometido. Estamos celebrando el orgullo de contar con una publicación propia, de calidad y en permanente crecimien- to, fundamentalmente porque constituye una apuesta, en el sentido fuerte de la palabra. Apuesta por una actividad reflexiva, por un tra- bajo teórico que es un desafío pero es, más que nada, una exigencia ético-profesional del Trabajo Social o, como diría Tere Matus, una urgencia política para la renovación de las prácticas sociales. Apuesta que se basa en la convicción de que un horizonte más justo no sólo es posible sino, sobre todo, necesario.
saqueos de 2001 en Argentina
Authors: Barrera Analé 
Published: February 2022

En el presente artículo, nos proponemos analizar las investigaciones que Javier Auyero y Nicolás Iñigo Carrera realizan en torno a los saqueos que tuvieron lugar en la Argentina en el marco de la crisis de 2001. Los autores, desde perspectivas teóricas diferentes, plantean una caracterización de los hechos, identifican y definen a los sujetos protagonistas, entendiendo a estos hechos en el marco de un determinado ciclo de protesta social. De esta manera, intentaremos exponer los aspectos centrales de sus trabajos y, a la vez, plantear ciertos elementos para su análisis. En este sentido, el objetivo no será plantear una comparación “aséptica” de los aportes de cada uno, sino identificar sus conceptualizaciones y sopesar los aportes que hacen al estudio de la protesta social en Argentina, particularmente a partir del aumento de la pobreza en el contexto socio histórico de finales de siglo XX y comienzos del XXI.
Pengaruh Keaktifan Belajar, Kemandirian Dan Kreativitas Terhadap Prestasi Belajar Matematika Siswa Kelas IX SMP
Authors: Achmad Aisyah Hariyani , Dinar Muhammad , Bernard B. 
Published: February 2022

Penelitian ini adalah penelitian ex-post facto yang bertujuan untuk mengetahui adanya pengaruh antara keaktifan belajar, kemandirian dan kreativitas terhadap prestasi belajar matematika siswa kelas IX SMP. Sampel dipilih secara acak dari populasi sebanyak tiga kelas dari sembilan kelas. Pengambilan data dilakukan dengan menggunakan angket dan tes prestasi belajar. Data tersebut dianalisis secara deskriptif dan inferensial. Hasil penelitian secara deskriptif diperoleh (1) Prestasi belajar matematika siswa berada pada kategori tinggi, (2) Keaktifan belajar berada pada kategori tinggi, (3) Kemandirian belajar berada pada kategori tinggi, (4) Kreativitas belajar berada pada kategori rendah. Secara inferensial diperoleh (1) Terdapat pengaruh antara keaktifan belajar, kemandirian belajar dan kreativitas belajar secara bersama-sama terhadap prestasi belajar matematika siswa, (2) Terdapat pengaruh signifikan antara keaktifan belajar terhadap prestasi belajar belajar matematika siswa dengan memperhatikan kemandirian belajar dan kreativitas belajar kelas, (3) Terdapat pengaruh signifikan antara kemandirian belajar terhadap prestasi belajar belajar matematika siswa dengan memperhatikan keaktifan belajar dan kreativitas belajar, (4) Tidak terdapat pengaruh signifikan antara kreativitas belajar terhadap prestasi belajar belajar matematika siswa dengan memperhatikan keaktifan belajar dan kemandirian belajar.
Kata kunci : Keaktifan Belajar, Kemandirian, Kreativitas, Prestasi Matematika

This study was ex-post facto research, which purposed to know the influences of learning activeness, independence and creativity toward Students’ Mathematics Learning Achievement on grade IX of SMP. Sample of study was chosen randomly three class from nine classes. Data were collected using the questionnaires and test learning achievement. The data were analyzed by Descriptive and Inferential. Descriptive analyze obtain (1) Students’ mathematics learning achievement are at high category, (2) Learning activeness are at high category, (3) Learning independence are at high category, (4) Learning creativity are at low category. Inferentially acquire (1) There is influences of learning activeness, learning independence and learning creativity together towards students’ mathematics learning achievement, (2) There is a positive influence of learning activeness toward students’ mathematics learning achievement by paying attention to the learning independence and learning creativity, (3) There is a positive influence of learning independence toward students’ mathematics learning achievement by paying attention to the learning activeness and learning creativity, (4) There was no influence of learning creativity toward students’ mathematics learning achievement by paying attention to the learning activeness and learning independence.
Keyword : Learning Activeness, Independence, Creativity, Mahtematics Achievement
Pengaruh Sistem Manajemen Pembelajaran Virtual Berbasis Schoology Terhadap Disposisi Matematis Siswa
Authors: Tahmir Suradi , Nasrullah N. , Hermia Eka 
Published: February 2022

Penelitian ini bertujuan untuk menunjukkan pengaruh penggunaan Sistem Manajemen Pembelajaran (SMP) virtual, yaitu schoology, terhadap disposisi matematis siswa dalam pembelajaran matematika. Penelitian ini tergolong eksperimen semu (quacy experiment), yang melibatkan dua kelas yang diberikan perlakuan yang berbeda, kelas pertama yang diberikan perlakuan menggunakan sistem manajemen pembelajaran virtual menggunakan schoology dengan model pembelajaran Blended Learning dan di sebut kelas eksperimen, sedangkan kelas kedua diajarkan dengan menggunakan model pengajaran langsung dan disebut kelas kontrol. Populasi dalam penelitian adalah semua siswa kelas XI di salah satu SMA negeri di Makassar. Pengambilan sampel dalam penelitian ini menggunakan teknik purposive sampling. Untuk pengumpulan data, instrumen yang digunakan adalah angket disposisi matematis (pre-nontest dan post-nontest) dan lembar observasi keterlaksanaan pembelajaran. Data tersebut dianalisis dengan teknik statistik deskriptif dan statistik inferensial. Hasil penelitian membuktikan bahwa penggunaan sistem manajemen pembelajaran virtual berbasis schoology dengan model pembelajaran blended learning terhadap disposisi matematis lebih baik dari pada model pengajaran langsung.Kata Kunci: SMP Virtual,Kelas Virtual, Schoology, Disposisi matematis This study aims to show the effect of the use of virtual Learning Management System (LMS), namely schoology, on the mathematical disposition of students in learning mathematics. This research is classified as quasi experiment, which involves two classes given different treatments, the first class is treated using a virtual learning management system using schoology with a Blended Learning learning model and called an experimental class, while the second class is taught using a model direct teaching and is called the control class. The population in this study were all students majoring in class XI in one of the state high schools in Makassar. Sampling in this study using purposive sampling technique. For data collection, the instruments used were a mathematical disposition questionnaire (pre-test and post-test) and an observation sheet of the implementation of learning. The data was analyzed with descriptive statistical techniques and inferential statistics. The results of the study prove that the virtual learning management systems based schoology with blended learning models towards mathematical dispositions is better than direct teaching models.Keywords: Virtual SMP, Virtual Class, Schoology Mathematical Disposition