bluuebunny/crossref_metadata_2025_split huggingface dataset:
«Місопогон» як приклад самопрезентації імператора Юліана
Authors: Pukhovets Dmytro 
Published: July 2022

У статті аналізується відома промова римського імператора IV ст. від Р.Х. Юліана «Місопогон» («Ненависник бороди») як приклад репрезентації свого образу підданим. Промова була написана на початку 363 р. в Антіохії перед тим, як правитель залишив місто задля участі у перській кампанії. Політика володаря в місті виявилася невдалою у багатьох аспектах, вона викликала незадоволення населення. Тому Юліан написав «Місопогон» щоб відбілити свою репутацію та покласти провину за політичні провали на самих антіохійців.
Автор статті визначає обставини написання промови, виокремлює засоби, які застосовуються Юліаном, щоб себе зобразити у гарному світлі, а антіохійців – у поганому, з’ясовує жанрову приналежність твору. Робиться висновок, як сам факт написання «Місопогону» може впливати на оцінку особливостей взаємовідносин римського імператора IV ст. та його підданих.
Questions of Ethnogenesis of the Belarusian People in Scientific Concept of Myron Korduba
Authors: Fedoriv Iryna 
Published: July 2022

In the article the scientific views of the prominent Ukrainian historian, professor of the Universities of Warsaw and Lviv Myron Korduba (1876-1947) on the origin of the Belarusian people are highlighted. The key works of the scientist on the problems of nation-building of the Eastern Slavs are taken into account, in particular, the little-known among Slavists study of M. Korduba «Some remarks on the origin of the Belarusian nation (in the margins of Dr. Jan Stankiewicz’s article)». The problem of ethnogenesis of the Belarusian people in the interpretation of M. Korduba is considered in the context of modern historiographical discourse.
Участь «Селянського союзу» у виборах до Сейму та Сенату Другої Речі Посполитої 1928 року
Authors: Bortnik Tetiana 
Published: July 2022

Проаналізовано участь партії «Селянський союз» у виборах до Сейму та Сенату Другої Речі Посполитої 1928 р. Висвітлено діяльність очільників політичної сили під час передвиборчої кампанії на рубежі 1927-1928 рр. Простежено хід переговорів між «Селянським союзом» та УНДО щодо створення єдиного Блоку національних меншин для участі у виборах. Стверджено, що у ході перемовин відбувся конфлікт між лідерами «сельсоюзників» – братами Павлом та Антоном Васиньчуками, тому останній вийшов зі складу партії та брав участь у виборах окремо – із Українським Народним Господарчим Списком. Акцентовано увагу на результатах парламентських виборів 1928 р. та їхньому впливові на подальшу діяльність «Селянського союзу».
Effect of Sacubitril/Valsartan on Reducing the Risk of Arrhythmia: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Authors: Wang Ruxin , Ye Haowen , Ma Li , Wei Jinjing , Wang Ying , Zhang Xiaofang , Wang Lihong 
Published: July 2022

Background and ObjectiveRelevant data of PARADIGM-HF reveals sacubitril/valsartan (SV) therapy led to a greater reduction in the risks of arrhythmia, and sudden cardiac death than angiotensin converting enzyme inhibitor (ACEI)/angiotensin receptor inhibitor (ARB) therapy in HFrEF, however, inconsistent results were reported in subsequent studies. Here, we conduct a meta-analysis of related randomized controlled trials (RCTs) to evaluate the protective effect of SV on reducing the risk of arrhythmias.Methods and ResultsRCTs focused on the difference in therapeutic outcomes between SV and ACEI/ARB were searched from PUBMED, EMBASE, ClinicalTrials.gov, and Cochrane Library. The results were extracted from each individual study, expressed as binary risk, 95% confidence interval (CI) and relative risk (RR). Sixteen RCTs including 22, 563 patients met the study criteria. Compared with ACEI/ARB therapy, SV therapy did significantly reduce in the risks of severe arrhythmias among patients with heart failure with reduced ejection fraction (HFrEF) (RR 0.83, 95% CI 0.73–0.95, p = 0.006), ventricular tachycardia (VT) among patients with HFrEF (RR 0.69, 95% CI 0.51–0.92, p = 0.01), cardiac arrest among patients with heart failure (HF) (RR 0.52, 95% CI 0.37–0.73, p = 0.0002), cardiac arrest among patients with HFrEF (RR 0.49, 95% CI 0.32–0.76, p = 0.001), cardiac arrest or ventricular fibrillation (VF) among patients with HF (RR 0.63, 95% CI 0.48–0.83, p = 0.001), and cardiac arrest or VF among patients with HFrEF (RR 0.65, 95% CI 0.47–0.89, p = 0.008), but reduced the risks of arrhythmias (RR 0.87, 95% CI 0.74–1.01, p = 0.07), atrial arrhythmias (RR 0.98, 95% CI 0.83–1.16, p = 0.85), and atrial fibrillation (RR 0.98, 95% CI 0.82–1.17, p = 0.82) among all patients with no significant between-group difference. The merged result was robust after sensitivity analysis, and there was no publication bias.ConclusionOur meta-analysis provides evidence that, compared with ACEI/ARB, SV can additionally reduce the risks of most arrhythmias, just the significant differences are revealed in reducing the risks of VT, severe arrhythmias, and cardiac arrest in patients with HFrEF. Besides, the positive effect of SV on VF according to statistical result of combining VF with cardiac arrest in patients with HFrEF is credibility.
Sex Differences in Clinical Characteristics and Prognosis in Primary Thrombotic Antiphospholipid Syndrome
Authors: Huang Yongfa , Liu Huazhen , Qi Wanting , Du Le , Li Mengtao , Zeng Xiaofeng , Guo Xiaoxiao , Zhao Jiuliang , Zhang Shuyang 
Published: July 2022

ObjectivesThis study aimed to investigate whether there are sex differences in clinical characteristics and prognosis in patients with primary thrombotic antiphospholipid syndrome (ptAPS).MethodsFrom January 2013 to July 2021, 154 consecutive patients diagnosed with ptAPS were prospectively recruited. Multivariable Cox regression was used to evaluate the association between gender and the composite endpoint including thromboembolic recurrence or all-cause death during follow-up.ResultsTotally, 80 (52%) male and 74 (48%) female patients with ptAPS were included, and men had a higher percentage of smokers/ex-smokers [50 (62%) vs. 6 (8%), p &lt; 0.001] and hyperhomocysteinemia [26 (32%) vs. 9 (12%), p = 0.003]. The baseline thromboembolic events were similar in two genders, except for limb ischemia [15 (19%) in men vs. 1 (1%) in women, p &lt; 0.001]. During a median follow-up of 42 months, the composite endpoint occurred in 30 (38%) male and 15 (20%) female patients (p = 0.019). Male gender [HR 2.499, 95% CI (1.316, 4.743), p = 0.005] and warfarin administration [HR 0.482, 95% CI (0.257, 0.905), p = 0.023] remained independent risk factors for the composite endpoint. Male gender [HR 3.699, 95% CI (1.699, 8.246), p = 0.001] and isolated lupus anticoagulant positivity [HR 2.236, 95% CI (1.039, 4.811), p = 0.040] were independent risk factors for thromboembolic recurrence.ConclusionThere are sex disparities in the clinical characteristics in patients with ptAPS and the male gender is an independent risk factor for the poor prognosis. Male patients with isolated lupus anticoagulant (LA) positivity have the highest risk of thromboembolic recurrence.
Global Landslide Forecasting System for Hazard Assessment and Situational Awareness
Authors: Khan Sana , Kirschbaum Dalia B. , Stanley Thomas A. , Amatya Pukar M. , Emberson Robert A. 
Published: July 2022

Landslides triggered by extreme rainfall can be devastating, resulting in loss of life, property, and infrastructure. Landslide forecasting systems provide an opportunity to build awareness of potential hazards and ultimately take preemptive measures. There is currently a dearth of forecasting systems that provide regional or global coverage, but these systems can offer important situational awareness in data-sparse, ungauged, or large-scale catchments. A near global, primarily satellite-based system called the Landslide Hazard Assessment for Situational Awareness (LHASA) provides near real-time estimates of potential landslide hazard and exposure around the world. In this work, a precipitation forecast module is introduced into LHASA to complement the existing LHASA framework and provide an estimate of landslide hazard up to 3 days in advance at 1 km resolution. The model-based Goddard Earth Observing System-Forward Processing (GEOS-FP) precipitation forecast product is used as the forcing input for the model in place of the satellite-based Integrated Multi-satellitE Retrievals for Global Precipitation Mission product. Soil moisture and snow depth from the GEOS-FP assimilated product are also incorporated. The study period January 2020–January 2021 is used to test the model performance against the LHASA near real-time estimates at multiple spatiotemporal scales. Validation of the model is carried out using a collection of rainfall-triggered landslide inventories from around the world as case studies to demonstrate the potential utility and limitations of this system. The rescaling of the GEOS-FP precipitation product is a critical step in incorporating the forecasted precipitation data within LHASA-Forecast (LHASA-F). Combining different streams of forecasted data within the LHASA-F framework shows promise, particularly for larger events at the 1- and 2-days lead time for events. Results indicate that for the case studies evaluated, the LHASA-F is generally able to resolve major landslide events triggered by extreme rainfall, such as from tropical cyclones. The analysis shows that landslide forecast outputs may be represented differently depending on the user’s needs. This framework serves as a first milestone in providing a global predictive view of landslide hazard.
Early Cretaceous Slump Deposits in Laiyang Group (Lingshan Island, East China): New Constraints for Provenance Identification and Tectonic Evolution
Authors: Wang Yuzhe , Qiu Longwei , Yang Yongqiang , Yang Baoliang , Dong Daotao , Khan Danish , Guo Zhongren 
Published: July 2022

The sedimentary strata in the Lingshan Island area are gaining attention because of their unique sedimentary and tectonic characteristics. However, the provenance and the depositional and tectonic setting in this area remain the focus of controversy. There is a significant slump deposit with lateral length up to 250 m in the Laohuzui section at the top of the Laiyang Group, which differs from the underlying turbidite deposits in morphology and composition. The sandstone in the Laohuzui section was continuously sampled and analyzed for major trace and rare earth elements. The results showed that the Laohuzui section is mixed with a continental margin provenance from the re-cyclic deposition in the arid region, which is different from the continental island arc provenance in the lower part of the Laiyang Group. Through the geochemical study of the igneous gravel contained in the olistolite and the comparison with the igneous rocks in the surrounding area, it is observed that the properties of the igneous gravel are most like those of the igneous rock deposit in the Zhucheng-Taolin area. In addition, the Lingshan Island and the Zhucheng-Taolin areas have similar sedimentary processes, suggesting that both received provenance from the Jiaonan uplift at the end of the Early Cretaceous. This study clarified the depositional processes of the later period of the Laiyang Group deposition in the Lingshan Island area.
The Lipid Profiles in Different Characteristics of Women with PCOS and the Interaction Between Dyslipidemia and Metabolic Disorder States: A Retrospective Study in Chinese Population
Authors: Guo Fei , Gong Zhentao , Fernando Taniya , Zhang Lingshan , Zhu Xiaoyong , Shi Yingli 
Published: July 2022

PurposeTo exhibit the lipid profiles in PCOS women with different characteristics and to access correlations between alternation of key lipid parameters and characteristics of PCOS.DesignA retrospective study.ParticipantsA total of 700 PCOS women were included.MethodsRetrospective study on 700 women (age 24.6 ± 4.7 years), diagnosed with PCOS in the outpatient department of Obstetrics and Gynecology Hospital of Fudan University according to Rotterdam criteria. Anthropometric features, hormone levels, lipid levels, and metabolic parameters were measured and compared between PCOS patients with different characteristics.ResultsThere was a high prevalence of dyslipidemia among Chinese PCOS patients (41.3%), and the most common pattern was low HDL. Patients with clinical hyperandrogenism presented with significantly decreased HDL and Apo-A levels. The levels of TG, LDL, Apo-B, TG/HDL, and Apo-B/Apo-A were significantly increased in the insulin resistance subgroup. The levels of TC and TG were significantly increased in the dysglycemia and T2DM women. And in general, the levels of TG, and Apo-B had an increasing trend with BMI. Moreover, AI, TG/HDL, and Apo-B/Apo-A ratios were associated with some characteristics of PCOS, such as insulin resistance, and obesity.ConclusionThe PCOS women with different characteristics presented with different lipid profiles, and there is a complex correlation between lipid metabolism and PCOS characteristics, which may explain the increased risk of long-term cardiovascular disease. Regular screening of blood lipids is essential for PCOS women. Identification of optimal subgroups in PCOS patients that need lipid-lowering treatment and therapeutic effectiveness is worth exploring.
Case Study of Successfully Staged Acid Fracturing on the Ultra-Deep Horizontal Well for the Qixia Fm HTHP Tight Carbonate Gas Reservoir in China
Authors: Liu Fei , Fan Yu , Li Li , Li Jinsui , Chen Yan , Lv Zefei , He Tingting 
Published: July 2022

The lower Permian Qixia formation gas reservoir is characterized by ultra-deep buried, high temperature and high pressure (HTHP), low porosity and permeability, ultra-high closure pressure, and thin thickness in the western Sichuan Basin, China. Acid fracturing has been adopted as the main well stimulation technology. The average test production of the acid-fractured vertical well was 46 × 104 m3/d. The horizontal well with staged acid fracturing is considered a reliable measure to enhance gas production. However, the staged acid fracturing on the ultra-deep horizontal well has been challenged. The reaction rates of conventional, self-diverting, and gelled acid and the acid-etched fracture conductivity experiments under HTHP are measured to optimize the acid fracturing technique. The reaction rate of gelled acid with Qixia Fm limy dolomite at 150°C is 3.4–6.7 times faster than that with dolomite and similar to that with limestone. The gelled acid with better retardation and friction reduction performance is selected as the main acid to increase the effective acid-etched fracture length. The acid-etched fracture conductivity can be greatly enhanced by using gelled acid, increasing acid volume, and closed fracture acidizing (CFA) under a closure stress of 50 MPa. Moreover, the feasibility of staged acid fracturing for ultra-deep horizontal wells is discussed. The first stage is assembled by fracturing sleeve, spared ball drop sleeve, and circulating valve to ensure activation of the fracturing channel. The tested production is significantly enhanced with temporary plugging and open-hole packer and sliding sleeve staged acid fracturing.
Soil Structural Quality and Relationships With Root Properties in Single and Integrated Farming Systems
Authors: Cavalieri-Polizeli Karina Maria Vieira , Marcolino Feliciano Canequetela , Tormena Cássio Antonio , Keller Thomas , Moraes Anibal de 
Published: July 2022

Single farming systems (SFS) such as monocultures may negatively affect soil structural quality. This study tested the hypothesis that integrated farming systems (IFS), i.e., the combination of cropping and forestry and/or livestock farming, improves soil structural quality, root development and soil organic carbon. An experimental area was set up in 2012 at the Canguiri experimental farm belonging to the Federal University of Paraná, Southern Brazil. The soils are predominantly Ferralsols. The experimental treatments representing different farming systems, organized in a random block design with three replicates, were: Forestry (F), Conventional Crop Production (C), Livestock (L), and integrated Crop-Forestry (CF), Crop-Livestock (CL), Livestock-Forestry (LF), and Crop-Livestock-Forestry (CLF). In situ measurements and sampling were carried out in the 0–0.3 m layer during summer 2019/20, and included soil penetration resistance (PR), soil structural quality based on visual evaluation of soil structure (SqVESS scores), root length (RL), root volume (RV) and soil organic carbon content (SOC). Soil structural quality, penetration resistance, root length and volume, and SOC varied between farming systems, but no significant differences were found between single (C, L, F) and integrated farming systems (CF, CL, LF, CLF). The single system Forestry (F) and the integrated systems including forestry (LF, CF, CLF) tended to have higher SqVESS scores, i.e. poorer soil structural quality, and higher PR, which we associate with the generally drier soil conditions that are due to higher soil water uptake and higher interception and reduce the frequency of wetting-drying cycles. Roots were concentrated in the shallow soil layer (0–0.1 m depth), and this was especially pronounced in the Crop (C) single farming system. Based on the measured values, our results suggest an acceptable soil structural quality in all farming systems. Our data revealed strong, significant relationships between soil structural quality, penetration resistance, root growth and SOC, demonstrating that improvements in soil structure results in lower soil penetration resistance, higher root volumes and higher SOC, and vice versa. Soil PR was positively correlated with SqVESS (R2 = 0.84), indicating that better soil structural quality resulted in lower soil mechanical resistance. This, in turn, increased root length and volume, which increases carbon input to soil and therefore increases SOC in the long run.
Proteomic Changes of Osteoclast Differentiation in Rheumatoid and Psoriatic Arthritis Reveal Functional Differences
Authors: Kovács Orsolya Tünde , Tóth Eszter , Ozohanics Olivér , Soltész-Katona Eszter , Marton Nikolett , Buzás Edit Irén , Hunyady László , Drahos László , Turu Gábor , Nagy György 
Published: July 2022

BackgroundOsteoclasts play a crucial role in the maintenance, repair, and remodeling of bones of the adult vertebral skeleton due to their bone resorption capability. Rheumatoid arthritis (RA) and psoriatic arthritis (PsA) are associated with increased activity of osteoclasts.ObjectivesOur study aimed to investigate the dynamic proteomic changes during osteoclast differentiation in healthy donors, in RA, and PsA.MethodsBlood samples of healthy donors, RA, and PsA patients were collected, and monocytes were isolated and differentiated into osteoclasts in vitro using macrophage colony-stimulating factor (M-CSF) and receptor activator of nuclear factor κB ligand (RANK-L). Mass spectrometry-based proteomics was used to analyze proteins from cell lysates. The expression changes were analyzed with Gene Set Enrichment Analysis (GSEA).ResultsThe analysis of the proteomic changes revealed that during the differentiation of the human osteoclasts, expression of the proteins involved in metabolic activity, secretory function, and cell polarity is increased; by contrast, signaling pathways involved in the immune functions are downregulated. Interestingly, the differences between cells of healthy donors and RA/PsA patients are most pronounced after the final steps of differentiation to osteoclasts. In addition, both in RA and PsA the differentiation is characterized by decreased metabolic activity, associated with various immune pathway activities; furthermore by accelerated cytokine production in RA.ConclusionsOur results shed light on the characteristic proteomic changes during human osteoclast differentiation and expression differences in RA and PsA, which reveal important pathophysiological insights in both diseases.
Carbohydrates Metabolic Signatures in Immune Cells: Response to Infection
Authors: Awad Kareem , Maghraby Amany Sayed , Abd-Elshafy Dina Nadeem , Bahgat Mahmoud Mohamed 
Published: July 2022

IntroductionMetabolic reprogramming in immune cells is diverse and distinctive in terms of complexity and flexibility in response to heterogeneous pathogenic stimuli. We studied the carbohydrate metabolic changes in immune cells in different types of infectious diseases. This could help build reasonable strategies when understanding the diagnostics, prognostics, and biological relevance of immune cells under alternative metabolic burdens.MethodsSearch and analysis were conducted on published peer-reviewed papers on immune cell metabolism of a single pathogen infection from the four known types (bacteria, fungi, parasites, and viruses). Out of the 131 selected papers based on the PIC algorithm (pathogen type/immune cell/carbohydrate metabolism), 30 explored immune cell metabolic changes in well-studied bacterial infections, 17 were on fungal infections of known medical importance, and 12 and 57 were on parasitic and viral infections, respectively.Results and DiscussionWhile carbohydrate metabolism in immune cells is signaled by glycolytic shift during a bacterial or viral infection, it is widely evident that effector surface proteins are expressed on the surface of parasites and fungi to modulate metabolism in these cells.ConclusionsCarbohydrate metabolism in immune cells can be categorized according to the pathogen or the disease type. Accordingly, this classification can be used to adopt new strategies in disease diagnosis and treatment.
The Neonatal Innate Immune Response to Sepsis: Checkpoint Proteins as Novel Mediators of This Response and as Possible Therapeutic/Diagnostic Levers
Authors: Hensler Emily , Petros Habesha , Gray Chyna C. , Chung Chun-Shiang , Ayala Alfred , Fallon Eleanor A. 
Published: July 2022

Sepsis, a dysfunctional immune response to infection leading to life-threatening organ injury, represents a significant global health issue. Neonatal sepsis is disproportionately prevalent and has a cost burden of 2-3 times that of adult patients. Despite this, no widely accepted definition for neonatal sepsis or recommendations for management exist and those created for pediatric patients are significantly limited in their applicability to this unique population. This is in part due to neonates’ reliance on an innate immune response (which is developmentally more prominent in the neonate than the immature adaptive immune response) carried out by dysfunctional immune cells, including neutrophils, antigen-presenting cells such as macrophages/monocytes, dendritic cells, etc., natural killer cells, and innate lymphoid regulatory cell sub-sets like iNKT cells, γδ T-cells, etc.Immune checkpoint inhibitors are a family of proteins with primarily suppressive/inhibitory effects on immune and tumor cells and allow for the maintenance of self-tolerance. During sepsis, these proteins are often upregulated and are thought to contribute to the long-term immunosuppression seen in adult patients. Several drugs targeting checkpoint inhibitors, including PD-1 and PD-L1, have been developed and approved for the treatment of various cancers, but no such therapeutics have been approved for the management of sepsis. In this review, we will comparatively discuss the role of several checkpoint inhibitor proteins, including PD-1, PD-L1, VISTA, and HVEM, in the immune response to sepsis in both adults and neonates, as well as posit how they may uniquely propagate their actions through the neonatal innate immune response. We will also consider the possibility of leveraging these proteins in the clinical setting as potential therapeutics/diagnostics that might aid in mitigating neonatal septic morbidity/mortality.