bluuebunny/crossref_metadata_2025_split huggingface dataset:
Safe peripheral blood stem cell collection in patients less than 10 kg: A single‐center review
Authors: Pasko Bryce E. , DomBourian Melkon , Helander Louise , Sanders Mary , Annen Kyle 
Published: December 2022

AbstractIntroductionPeripheral blood stem cell collection (PBSCC) is well‐documented in adults and pediatric patients with larger total blood volume (TBV). However, very little data are available for the successful PBSCC of pediatric patients weighing less than 10 kg. Here, we highlight our institutional approach to PBSCC in this smaller‐sized patient population.MethodsOur protocol, including blood prime, was reviewed for PBSCC for bone marrow transplantation (BMT) in 18 children weighing 4.5‐9.9 kg who safely underwent 37 PBSCC procedures at a single institution, Children's Hospital Colorado, between September 2016 and February 2022.ResultsWe attained the individualized collection goals in all 18 patients with an average yield of 17.03 million CD34+ cells/kg of patient body weight (range: 0.84‐67.45 million/kg). The average collection efficiency of the procedures was 41.5% (range: 23.0%‐71.5%). We performed all 37 procedures safely and without complication. The estimated average TBV was 587 mL (range: 351‐765 mL), the average blood volume processed was 596 mL (range: 351‐756 mL), and the average TBVs processed was 2.5 (range: 1‐4).ConclusionPBSCC in patients ranging from 4.5 to 9.9 kg is safe and effective for collecting peripheral blood stem cells for BMT.
On the equivalence of certain quasi‐Hermitian varieties
Authors: Aguglia Angela , Giuzzi Luca 
Published: December 2022

AbstractBy Aguglia et al., new quasi‐Hermitian varieties in depending on a pair of parameters from the underlying field have been constructed. In the present paper we study the structure of the lines contained in and consequently determine the projective equivalence classes of such varieties for odd and . As a byproduct, we also prove that the collinearity graph of is connected with diameter 3 for .
Importance of Target‐Mediated Drug Disposition (TMDD) of Small‐Molecule Compounds and Its Impact on Drug Development—Example of the Class Effect of HSD‐1 Inhibitors
Authors: An Guohua , Katz David A. 
Published: December 2022

AbstractWith more potent drug candidates being developed, the incidence of target‐mediated drug disposition (TMDD) in small‐molecule compounds has significantly increased in the past decade. Moreover, TMDD appears to apply to some small‐molecule compound classes. The main purpose of the current review is to increase the awareness of TMDD in a series of small‐molecule inhibitors of 11β‐hydroxysteroid dehydrogenase type 1 (HSD‐1) using ABT‐384, SPI‐62, MK‐0916, BMS‐823778, and BI‐187004 as case examples. Although developed independently by different pharmaceutical companies, these HSD‐1 inhibitors demonstrated strikingly similar nonlinear pharmacokinetic behaviors when wide dose ranges were evaluated in first‐in‐human (FIH) single ascending dose (SAD) and multiple ascending dose (MAD) studies. Recognizing TMDD in small‐molecule compounds is important, as the information can be leveraged to select the appropriate dose regimen, improve clinical trial design, as well as predict pharmacological target occupancy. In this review, we summarize the general pharmacokinetic features that facilitate the recognition of small‐molecule TMDD, provide case examples of specific HSD‐1 inhibitors, highlight the importance of recognizing TMDD of small‐molecule compounds during clinical development, and comment on the importance of utilizing pharmacometric modeling to facilitate the quantitative understanding of small‐molecule compounds exhibiting TMDD.
Maternal and neonatal safety of COVID‐19 vaccination during the peri‐pregnancy period: A prospective study
Authors: Li Minghui , Hao Jianzhen , Jiang Tingting , Deng Wen , Lu Huihui , Wang Shiyu , Wan Gang , Xie Yao , Yi Wei 
Published: December 2022

AbstractBackgroundTo investigate the safety of inactivated COVID‐19 vaccine in Chinese pregnant women and their fetuses when inoculated during the peri‐pregnancy period.MethodsEligible pregnant women were prospectively collected and divided into a vaccine group (n = 93) and control group (n = 160) according to whether they had been vaccinated against COVID‐19 within 3 months before their last menstruation period (LMP) and after pregnancy. Demographic data of couples, complications during pregnancy and delivery of pregnant women, and data of newborns at birth were collected.ResultsSixty‐six women were vaccinated with a median time of 35.5 (range = 0–91) days before LMP, and 27 women were vaccinated with a median time of 17 (range = 1–72) days after LMP. The incidence of premature rupture of membrane (PROM) in the vaccine group was significantly higher than that in the control group (16.13% vs. 6.88%, p = 0.019). Multivariate logistic regression analysis revealed that maternal peri‐pregnancy COVID‐19 vaccination was not an independent risk factor for PROM (odds ratio: 2.407, 95% confidence interval: 0.932–6.216, p = 0.069). There was no difference in the incidence of other complications during pregnancy and delivery between the two groups. A total of 253 neonates were delivered, including two cases with congenital abnormalities in each group. The incidence of congenital abnormalities between the two groups was similar (2.15% vs. 1.25%, p = 0.626). There was no difference in neonatal length, weight, head circumference, and Apgar score between the two groups (p > 0.05), but the incidence of neonatal jaundice in the vaccine group was significantly higher than that in the control group (20.43% vs. 7.5%, p = 0.002). Multivariate logistic regression analysis revealed that maternal peri‐pregnancy vaccination, postpartum blood loss, cesarean section, 1‐min Apgar score, and paternal smoking were independent risk factors for neonatal jaundice.ConclusionsIt is safe for pregnant women and their fetuses to be inoculated the inactivated COVID‐19 vaccine during the peri‐pregnancy period, but attention should be paid to neonatal jaundice.
Emotional recognition across the adult lifespan: Effects of age, sex, cognitive empathy, alexithymia traits, and amygdala subnuclei volumes
Authors: Malykhin Nikolai , Pietrasik Wojciech , Aghamohammadi‐Sereshki Arash , Ngan Hoang Kim , Fujiwara Esther , Olsen Fraser 
Published: December 2022

AbstractThe ability to recognize others' emotions is vital to everyday life. The goal of this study was to assess which emotions show age‐related decline in recognition accuracy of facial emotional expressions across the entire adult lifespan and how this process is related to cognitive empathy (Theory of Mind [ToM]), alexithymia traits, and amygdala subnuclei volumes in a large cohort of healthy individuals. We recruited 140 healthy participants 18–85 years old. Facial affect processing was assessed with the Penn Emotion Recognition task (ER40) that contains images of the five basic emotions: Neutral, Happy, Sad, Angry, and Fearful. Structural magnetic resonance imaging (MRI) datasets were acquired on a 4.7T MRI system. Structural equation modeling was used to test the relationship between studied variables. We found that while both sexes demonstrated age‐related reduction in recognition of happy emotions and preserved recognition of sadness, male participants showed age‐related reduction in recognition of fear, while in female participants, age‐related decline was linked to recognition of neutral and angry facial expressions. In both sexes, accurate recognition of sadness negatively correlated with alexithymia traits. On the other hand, better ToM capabilities in male participants were associated with improvement in recognition of positive and neutral emotions. Finally, none of the observed age‐related reductions in emotional recognition were related to amygdala and its subnuclei volumes. In contrast, both global volume of amygdala and its cortical and centromedial subnuclei had significant direct effects on recognition of sad images.
Ambiguity Tolerance Can Improve through Poetry Appreciation and Creation
Authors: Hitsuwari Jimpei , Nomura Michio 
Published: December 2022

ABSTRACTAmbiguity tolerance is an individual trait indicating low aversion to ambiguity that is closely related to creativity. Appreciation and discussion of art are known to improve ambiguity tolerance, but the effects of appreciation and discussion have not been studied separately. In this study, we used haiku poetry with the characteristic of ambiguity to confirm the effect of appreciation by separating it from the discussion. Additionally, we conducted haiku creation to examine the effect of creation. To this end, 137 participants answered the ambiguity tolerance scale at five time points: before and after haiku appreciation and creation, and 1 week later. We also used the Multidimensional Attitude toward Ambiguity Scale, which organizes ambiguity tolerance into three subfactors. These subfactors are discomfort with ambiguity, absolutism, and the need for complexity and novelty, which correspond to the affective, cognitive, and epistemic aspects of ambiguity attitudes, respectively. The results showed that absolutism, which is the cognitive aspect of ambiguity tolerance, decreased after the appreciation and creation of haiku, and this effect persisted after 1 week. This result indicates that cognitive changes such as the acceptance of ambiguity can occur through the appreciation and creation of haiku, which require various interpretations and choices.
Sterols and pentacyclic triterpenoids from nettle root: content and composition as affected by pressurized liquid extraction
Authors: Cegledi Ena , Repajić Maja , Balbino Sandra , Peričić Matea , Dragović‐Uzelac Verica 
Published: December 2022

AbstractBACKGROUNDNettle is a medicinal plant rich in bioactive molecules. The composition of nettle leaves and stems has been extensively studied, whereas the root has been insufficiently investigated. Therefore, the present study aimed to optimize the parameters of advanced extraction technique, pressurized liquid extraction (PLE), for the lipid fraction of nettle root rich in triterpenoid derivatives and to compare the efficiency of isolation under optimal conditions with conventional Soxhlet extraction (SE).RESULTSThe PLE yields ranged from 0.39–1.63%, whereas the total content of triterpenoid derivatives ranged from 43.50–78.26 mg 100 g−1, with nine sterols and three pentacyclic triterpenoids identified and quantified within a total range of 42.81–76.57 mg 100 g−1 and 0.69–1.68 mg 100 g−1 dried root, respectively. The most abundant sterol and pentacyclic triterpenoid were β‐sitosterol and β‐amyrin acetate, with mean values of 50.21 mg 100 g−1 and 0.56 mg 100 g−1 dried root.CONCLUSIONThe optimal PLE conditions were 150 °C/5 min/four cycles and showed significantly better performance compared to SE (68 °C, 8 h), establishing an excellent technique for the isolation of the nettle root lipid fraction. Also, triterpenoid derivatives from nettle could be used as functional ingredients for the development of new foods and dietary supplements. © 2022 Society of Chemical Industry.
Incidence of radiation‐associated sarcoma after breast‐conserving surgery plus radiation
Authors: Wiener Alyssa A. , Schumacher Jessica R. , Hanlon Bret , Anderson Bethany , Neuman Heather B. 
Published: December 2022

AbstractBackgroundRadiation‐associated sarcoma (RAS) is a rare sequela of radiotherapy. Radiotherapy modalities for breast conservation and radiation treatment (BCT) have changed over time. We sought to determine if the incidence of RAS after BCT has changed over time.MethodsWe identified breast cancer survivors (diagnosed 1988–2012) treated with BCT within the SEER database. We excluded patients with prior cancer, <1‐year follow‐up/survival, and nonexternal beam radiation (n = 276 301). We identified patients with a subsequent chest sarcoma diagnosis. The primary predictor variable was a 5‐year period of breast cancer diagnosis year (1988–1992, 1993–1997, etc.). The incidence of sarcoma was estimated by the Kaplan–Meier method, censoring at sarcoma diagnosis, death, or last follow‐up (available through December 2017). Given the known latency of RAS, we used Joinpoint analysis to identify the time point at which RAS incidence significantly increased (start of the analytic window). A log‐rank test assessed differences in RAS incidence by diagnosis year.ResultsThe incidence of RAS was 0.03% at 5 years (95% confidence interval [CI]: 0.03–0.04) and 0.16% at 10 years (95% CI: 0.14–0.18). No statistical difference in RAS incidence by diagnosis year was observed (p = 0.2).ConclusionsRAS remains a rare but persistent sequela after BCT. As new radiation modalities become more common, ongoing surveillance is necessary to track these rare events.
Outcomes of plastic surgical reconstruction in extremity and truncal soft tissue sarcoma: Results from the US Sarcoma Collaborative
Authors: Thalji Sam Z. , Ethun Cecilia G. , Tsai Susan , Gamblin T. Clark , Clarke Callisia N. , Bedi Meena , King David , LoGiudice John , Poultsides George , Grignol Valerie P. , Tseng Jennifer , Votanopoulos Konstantinos , Fields Ryan C. , Cardona Kenneth , Mogal Harveshp 
Published: December 2022

AbstractBackgroundThis study aimed to define how utilization of plastic surgical reconstruction (PSR) affects perioperative outcomes, locoregional recurrence‐free survival (LRRFS), and overall survival (OS) after radical resection of extremity and truncal soft tissue sarcoma (ETSTS). The secondary aim was to determine factors associated with PSR.MethodsPatients who underwent resection of ETSTS between 2000 and 2016 were identified from a multi‐institutional database. PSR was defined as complex primary closure requiring a plastic surgeon, skin graft, or tissue‐flap reconstruction. Outcomes included PSR utilization, postoperative complications, LRRFS, and OS.ResultsOf 2750 distinct operations, 1060 (38.55%) involved PSR. Tissue‐flaps (854, 80.57%) were most commonly utilized. PSR was associated with a higher proportion of R0 resections (83.38% vs. 74.42%, p < 0.001). Tissue‐flap PSR was associated with local wound complications (odds ratio: 1.81, confidence interval: 1.21–2.72, p = 0.004). Neither PSR nor postoperative complications were independently associated with LRRFS or OS. High‐grade tumors (1.60, 1.13–2.26, p = 0.008) and neoadjuvant radiation (1.66, 1.20–2.30, p = 0.002) were associated with the need for PSR.ConclusionPatients with ETSTS undergoing resection with PSR experienced acceptable rates of complications and a higher rate of negative margins, which were associated with improved LRRFS and OS. High tumor grade and neoadjuvant radiation were associated with requirement of PSR.
Ultrasound‐Guided A1 Pulley Release Versus Classic Open Surgery for Trigger Digit
Authors: Rodríguez‐Maruri Guillermo , Rojo‐Manaute Jose Manuel , Capa‐Grasa Alberto , Chana Rodríguez Francisco , Cerezo López Eugenio , Vaquero Martín Javier 
Published: December 2022

ObjectivesWe compared an ultra‐minimally invasive ultrasound‐guided percutaneous A1 pulley release and a classic open surgery for trigger digit.MethodsWe designed a single‐center randomized control trial. All cases had clinical signs of primary grade III trigger digit. Concealed allocation (1:1) was used for assigning patients to each group and data collectors were blinded. The Quick‐Disabilities of the Arm, Shoulder, and Hand (Quick‐DASH) questionnaire was our primary variable. Quick‐DASH, two‐point discrimination, grip strength, time until stopping analgesics, having full digital range of motion and restarting everyday activities were registered on the 1st, 3rd, and 6th weeks, 3rd and 6th months, and 1st year after the procedure.ResultsWe randomized 84 patients to ultrasound‐guided release and classic open surgery. Quick‐DASH scores significantly favored the percutaneous technique until the 3rd month: 7.6 ± 1.2 versus 15.3 ± 2.4 (mean ± standard error of the mean). The percutaneous group obtained significantly better results in all the variables studied: time until stopping analgesics, achieving full range of motion and restarting everyday activities. Grip strength was significantly better in the percutaneous group for the 1st week only. Five cases of moderate local pain were observed in the open technique. There was one case of transient nerve numbness per group.ConclusionsThe ultra‐minimally invasive ultrasound‐guided A1 pulley release was clinically superior to the classic open surgery in functional recovery with a lower complication rate.
Effect of guselkumab on serum biomarkers in Japanese palmoplantar pustulosis patients in a randomized phase 3 study
Authors: Morita Akimichi , Chen Yanqing , Leung Monica W. L. , Kawashima Naoko , Terui Tadashi 
Published: December 2022

AbstractBackgroundIt is reported that treatment of palmoplantar pustulosis (PPP) with guselkumab has greater improvement in clinical responses in terms of palmoplantar pustulosis area severity index (PPPASI) score. Here, we present the effect of guselkumab (100 and 200 mg) on PPP‐related serum proteins and their association with clinical responses.ObjectivesTo analyze the effects of guselkumab treatment on PPP‐related circulating serum proteins up to Week 72 and evaluate their association with clinical responses.MethodsSerum cytokines (interleukin [IL]‐17A, IL‐17F, IL‐22, tumour necrosis factor‐alpha, interferon‐gamma) and 184 inflammation/immune activation‐related serum proteins were evaluated. Baseline cytokine levels for patients with PPP were compared with healthy controls (HCs) to detect differentially expressed serum proteins using Welch's t‐test. Correlation with individual PPPASI scores was assessed to explore associations with disease severity. Guselkumab treatment‐associated pharmacodynamic (PD) effects were evaluated as fold changes in cytokine levels compared with baseline.ResultsBaseline serum IL‐17A, IL‐17F and IL‐22 levels were elevated in PPP patients (n = 159) compared with HCs (n = 25) and were significantly correlated with baseline PPPASI disease scores. Serum cytokines were reduced following guselkumab treatment, with maximal reduction at Week 72 for both doses (all p < 0.01). Lower levels of IL‐17A, IL‐17F and IL‐22 were associated with PPPASI improvement at Week 72. Olink platform analysis identified a decrease in chemokine ligand‐19 and IL‐6 levels with guselkumab compared with placebo. However, the difference between the treatment groups was not significant. The biomarker effect of guselkumab 100 versus 200 mg groups was comparable, suggesting the PD effect is plateaued and higher than 200 mg is unlikely to increase biomarker changes.ConclusionsTargeting IL‐23 with guselkumab in PPP led to a progressive reduction in IL‐17A, IL‐17F and IL‐22 in serum, and lower serum levels of these Th17/Th22 cytokines were associated with better PPPASI response after treatment.Clinical Trials.gov identifierNCT02641730.
Post‐emergence movements and habitat use by hatchling diamondback terrapins
Authors: Decker Carolyn E. , Buchanan Scott W. , Karraker Nancy E. 
Published: December 2022

AbstractDiamondback terrapins (Malaclemys terrapin) inhabit estuarine environments, and adult females typically nest in coastal uplands. Hatchlings emerging from nests overwinter on land and in coastal salt marshes, but the proportions that use each land cover type is not well documented. From 2019 to 2021, we tracked movements and habitat use of hatchlings post‐emergence to determine the importance of upland overwintering sites to a terrapin population in Rhode Island, USA. In late summer and early fall, we attached a radio‐transmitter and passive integrated transponder (PIT) tag (n = 46) or only a PIT tag (n = 132) to carapaces of hatchlings emerging from nests. From August to June, we tracked the hatchlings via radio‐telemetry and a sweeping PIT tag antenna, successfully documenting the fates of 46.6% of them (n = 83). This group included 23 hatchlings that overwintered in the upland, 11 hatchlings that moved to the salt marsh in fall, 46 predated hatchlings, and 3 hatchlings dead from unknown causes. Upon emergence from their nests, 68% of hatchlings dispersed toward water and 32% of hatchlings dispersed away from water. In the uplands, hatchlings typically overwintered within about 2 m of habitat edges. Movement in the uplands peaked from late August to early October, then ceased until hatchlings re‐emerged in late April through early June. To protect terrapins, we recommend limiting the use of heavy equipment (e.g., mowers, tillers) in vegetated uplands near nest sites, and scheduling vegetation management for colder months (Nov–Mar in New England, USA) when hatchlings are inactive.
Influences on technology use and interpretation among young people living with type 1 diabetes
Authors: Cushley Laura N. , Krezel Aniela , Curran Katie , Parker Kathryn , Millar Sarinda , Peto Tunde 
Published: December 2022

AbstractAimsTo characterise continuous glucose monitor and flash glucose monitor use and related issues (both positive and negative) in the population of children and young people living with type 1 diabetes in the Southern Health and Social Care Trust (SHSCT), Northern Ireland.MethodsFour focus groups were conducted in the SHSCT with people with type 1 diabetes and their families, to assess opinions of diabetes technology. In addition, questionnaires were distributed to diabetes specialist nurses (DSNs), young people and their families about use and access to diabetes technology.ResultsQuestionnaires were completed by 68 children, young people (0–18 years) and their parents/guardians. Nearly all (98.5%) had access to their own diabetes related data, and 70.6% used diabetes data systems, for example, Libreview. Most of those using these systems found them beneficial and easy for daily use and clinical review.Most DSNs (83.9%) agreed that the systems were easy to use, and 82.3% were confident in interpreting the data accurately. DSNs felt virtual review was beneficial in over half of young people with 62.9% advising changes to diabetes management based on the data.Focus groups participants deemed diabetes technology a ‘gamechanger’ and ‘lifechanging’. Some drawbacks included ‘disruptive’ alarms, self‐confidence issues, visible diabetes technology and problems in school.ConclusionsMost young people, their families and healthcare professionals reported they were confident in interpreting diabetes data and technology was easy to use. Diabetes technology could improve access to care through virtual clinics, improve clinical outcomes and enhance quality of life.
Marked weight loss on liraglutide 3.0 mg: Real‐life experience of a Swiss cohort with obesity
Authors: Santini Sara , Vionnet Nathalie , Pasquier Jérôme , Gonzalez‐Rodriguez Elena , Fraga Montserrat , Pitteloud Nelly , Favre Lucie 
Published: December 2022

AbstractObjectiveThis study investigated the effectiveness of liraglutide 3.0 mg daily in combination with a standardized multidisciplinary intervention on body weight and body composition changes in a real‐life setting.MethodsA prospective, observational cohort study design was used. Adult patients with BMI > 35 kg/m2, or BMI > 28 kg/m2 with greater than or equal to one metabolic comorbidity, were included (n = 54, 65% women). Liraglutide treatment was covered by Swiss health insurance. Clinical and biological data were collected at baseline, 4 months, and 10 months. Body composition was assessed by dual‐energy x‐ray absorptiometry at baseline and 10 months.ResultsAt 10 months, mean (SD) percentage weight loss (WL%) was −12.4% (5.5%) or −14.1 (6.6) kg. WL% was ≥5% in 87% of patients at 4 months and in 96% at 10 months. WL% was higher in women (−9.5% [3.1%] vs. men −7.2% [2.5%], p = 0.02) at 4 months and persisted at 10 months (−13.7% [5.2%] vs. −9.6% [5.1%], p = 0.006). WL% was associated with baseline percentage fat mass but not with age or BMI. Body composition showed a decrease in fat mass, visceral adipose tissue, and absolute lean mass.ConclusionsIn a real‐world setting, liraglutide 3.0 mg led to beneficial changes in WL and body composition, with a greater impact in women.