bluuebunny/crossref_metadata_2025_split huggingface dataset:
Motivational Interviewing to Improve the Uptake of Colorectal Cancer Screening: A Systematic Review and Meta-Analysis
Authors: Long Novia Niannian , Lau Michele Petrova Xin Ling , Lee Ainsley Ryan Yan Bin , Yam Natalie Elizabeth , Koh Nicholas Ye Kai , Ho Cyrus Su Hui 
Published: May 2022

IntroductionColorectal cancer screening when done early can significantly reduce mortality. However, screening compliance is still lower than expected even in countries with established screening programs. Motivational interviewing is an approach that has been explored to promote behavioral change including screening compliance. This review synthesizes the efficacy of motivational interviewing in promoting uptake of colorectal screening modalities and is the only review so far that examines motivational interviewing for colorectal cancer screening alone.MethodsA systematic review and meta-analysis was conducted to examine the effects of motivational interviewing for colorectal cancer screening. PubMed, EMBASE, CENTRAL, PsycINFO, and CINAHL were searched to identify eligible studies from inception to June 2021 and selection criteria was defined. Risk of bias was assessed using the Cochrane Risk of Bias 2.0 tool. The DerSimonian and Laird random effects model was used in the statistical analysis for studies included in the meta-analysis.ResultsFourteen studies from 14 randomized-controlled trials with a low to moderate risk of bias were analyzed. 8 studies in the systematic review showed that motivational interviewing is superior to a control group. Meta-analysis was conducted on 11 studies and showed that motivational interviewing is statistically significant in increasing colorectal cancer screening rates in both intention-to-treat and per-protocol analysis. Timing of data collection of colorectal cancer screening rates did not make a significant difference to the efficacy of motivational interviewing. Studies that offered and accepted a mixture of colorectal screening modalities such as colonoscopy and fecal immunochemical tests were significantly more likely to have favorable colorectal screening outcomes. Heterogeneity in intervention was noted between studies, specifically differences in the training of interventionists, intervention delivery and comparator components.ConclusionMotivational interviewing is a tailored intervention demonstrating mixed evidence in improving colorectal cancer screening attendance amongst individuals. More research is needed to rigorously compare the effect of motivational interviewing alone vs. in combination with other screening promotion strategies to enhance colorectal cancer screening compliance.
Is There an “Acquired Idiopathic Head-Shaking Nystagmus”?—A Discussion of Mechanisms and Clinical Implications Based on a Case Report
Authors: Filippopulos Filipp M. , Zwergal Andreas , Huppert Doreen 
Published: May 2022

BackgroundHead-shaking nystagmus (HSN) occurs in both peripheral and central vestibular disorders. In most cases, HSN can be attributed to an asymmetric peripheral vestibular input or a structural lesion mostly in the cerebellum affecting the central velocity storage mechanism. An isolated HSN is very rare.Case PresentationWe report on a young female patient with the clinical picture of recurrent episodes of vertigo, which were induced by fast head movements and were accompanied by a severe right-beating HSN with a long time constant of 60 s. There was no other clinical and instrument-based evidence of peripheral vestibular dysfunction (including video head impulse test, caloric test, vestibular-evoked myogenic potentials) or indication of a structural lesion in the nodulus, uvula or pontomedullary brainstem on fine-slice magnetic resonance imaging. She had no previous history of migraine, hearing deficits, or other focal neurological symptoms. Diagnostic criteria for vestibular paroxysmia, vestibular migraine, benign peripheral paroxysmal vertigo, or any other known vestibular disorders were not fulfilled. Chart review in the database of the German Center for Vertigo and Balance Disorders indicated eight additional patients with a similar clinical phenotype between 2018 and 2022.ConclusionWe propose a clinical entity called acquired idiopathic head shaking nystagmus (aiHSN) as a rare cause of episodic vertigo induced by fast head movements. Nystagmus characteristics suggest a subtle functional pathology of the central velocity storage mechanism in the nodulus and uvula, which is exacerbated during symptomatic episodes.
Sexual Dimorphism of Dexamethasone as a Prophylactic Treatment in Pathologies Associated With Acute Hypobaric Hypoxia Exposure
Authors: Chanana Neha , Palmo Tsering , Sharma Kavita , Kumar Rahul , Shah Bhushan , Mahajan Sudhanshu , Palleda Girish M. , Gupta Mohit D. , Kukreti Ritushree , Faruq Mohammad , Thinlas Tashi , Graham Brian B. , Pasha Qadar 
Published: May 2022

Dexamethasone can be taken prophylactically to prevent hypobaric hypoxia-associated disorders of high-altitude. While dexamethasone-mediated protection against high-altitude disorders has been clinically evaluated, detailed sex-based mechanistic insights have not been explored. As part of our India-Leh-Dexamethasone-expedition-2020 (INDEX 2020) programme, we examined the phenotype of control (n= 14) and dexamethasone (n= 13) groups, which were airlifted from Delhi (∼225 m elevation) to Leh, Ladakh (∼3,500 m), India, for 3 days. Dexamethasone 4 mg twice daily significantly attenuated the rise in blood pressure, heart rate, pulmonary pressure, and drop in SaO2resulting from high-altitude exposure compared to control-treated subjects. Of note, the effect of dexamethasone was substantially greater in women than in men, in whom the drug had relatively little effect. Thus, for the first time, this study shows a sex-biased regulation by dexamethasone of physiologic parameters resulting from the hypoxic environment of high-altitude, which impacts the development of high-altitude pulmonary hypertension and acute mountain sickness. Future studies of cellular contributions toward sex-specific regulation may provide further insights and preventive measures in managing sex-specific, high-altitude–related disorders.
Pilot Study on the Effect of a Single Topical Application of Trichloroacetic Acid 85% on Normal Cervical Tissue
Authors: Nuranna Laila , Lubis Dolly N. , Arozal Wawaimuli , Purbadi Sigit , Barinda Agian Jeffilano , Purwoto Gatot , Rustamadji Primariadewi , Putra Andi D. , Utami Tofan W. , Kekalih Aria 
Published: May 2022

Background: Early detection and treatment of cervical intraepithelial neoplasia (CIN) through a “see and treat” approach is a pillar of cervical cancer prevention programs in developing countries such as Indonesia. One of the major challenges faced is the limited N2O or CO2 gas supply for cryotherapy. Thus, an alternative therapeutic method such as trichloroacetic acid (TCA) topical application is needed as an alternative solution. The effectiveness of this therapy will depend on its destructive effect on eliminating the whole lesion in CIN.Objective: To estimate the extent of damage in the normal cervical tissue after a single topical application of 85% TCA solution.Design and Methods: This research was an intervention study carried out by applying ±5 ml of 85% TCA solution into the cervix of 40 patients scheduled for total hysterectomy for indications other than cervical pathology 24 h before surgery. The extent of tissue destruction was determined microscopically using histopathological specimens. The study protocol is registered at www.clinicaltrial.gov (ID NCT04911075).Results: In the final analysis, 39 subjects were included. The necrotic area was detected at the superficial layer, accompanied by the full epithelial erosion thickness. In addition, there were also fibrotic areas resembling burned tissue in the stroma. The mean depth of destruction was 1.16 ± 0.01 mm in the anterior lip and 1.01 ± 0.06 mm in the posterior lip. There was no significant depth difference between the anterior and posterior lips (p ≥0.05). Moreover, the 85% TCA topical application was tolerable, as represented by the fact that the vast majority (82.1%) of participants experienced pain with a visual analog scale score of &lt;4.Conclusion: Single dose of TCA 85% in topical solution was able to destroy the normal cervical tissue with a deeper mean depth than the mean depth of CIN III in squamous epithelium.
Trauma, Mental Health Distress, and Infectious Disease Prevention Among Women Recently Released From Incarceration
Authors: Johnson Karen A. , Hunt Timothy , Puglisi Lisa B. , Maeng Daniel , Epa-Llop Amali , Elumn Johanna E. , Nguyen Antoinette , Leung Ashley , Chen Rachel , Shah Zainab , Wang Jiayi , Johnson Rachel , Chapman Benjamin P. , Gilbert Louisa , El-Bassel Nabila , Morse Diane S. 
Published: May 2022

BackgroundU.S. women recently released from incarceration experience significantly higher rates of trauma and exacerbation of mental health conditions, and the period following release has been identified as a window of heightened risk for mental health distress and human immunodeficiency virus (HIV), sexually transmitted infections (STI) and hepatitis C (HCV) transmissions. Despite these vulnerabilities, and an urgent need for supports, optimal engagement strategies remain unclear. WORTH Transitions is a program made up of two evidence-based interventions focused on improving the health of women returning to the community from incarceration with substance use disorders. Combining the two was designed to reduce HIV/STIs/HCV risks and increase overall health treatment engagement using a community health worker led intervention.MethodsWe examined associations between trauma, mental health symptomology, and HIV/STI/HCV outcomes among women who engaged in the WORTH Transitions intervention (N = 206) Specifically, bivariate and longitudinal multivariate models were created to examine associations between trauma and mental health distress (defined as depressive and PTSD symptoms), on (1) types of engagement in HIV/STIs/HCV prevention and behavioral health services; and (2) HIV/STIs/HCV risk outcomes. The women who engaged in the intervention were 18 years and older and some were White, Black and other racial or ethnic minority.ResultsPTSD symptomology and being a Black or indigenous woman of color was significantly (p = 0.014) associated with individual or group session engagement. Neither trauma nor PTSD symptoms were associated with higher HIV/STIs/HCV risks. Instead, relative to those who did not engage in HIV/STI/HCV risky behaviors, PTSD symptomology (p = 0.040) was associated with more than 3-fold increase in the probability of being lost to follow up (relative risk ratio = 3.722).ConclusionGiven the impact of PTSD-related symptoms on driving both engagement in HIV/STIs/HCV prevention services and intervention attrition among women leaving incarceration, physical and behavioral health interventions must be both overtly trauma- and mental health-informed. As was the case with WORTH Transitions, physical and behavioral health services for this population must include intentional and active support of the forms of treatment participants endorse to ensure maximal engagement.
Low-Level Knowledge and Associated Factor of Sexual and Reproductive Health Rights Among Aksum University Students, Aksum Ethiopia
Authors: Berhe Elsa Tesfa , Ayene Mlite , Gebregyorgis Tsigehana , Hagos Merhawit Gebremeskel , Gebremeskel Teferi Gebru 
Published: May 2022

BackgroundReproductive health rights in Africa are unknown. According to international studies, reproductive health rights of young people particularly university students, are violated, and most of these violations go unreported due to a lack of information and awareness of these rights. The aim of this study was to assess the level of knowledge and associated factors on sexual and reproductive health rights in Ethiopia.MethodsInstitution-based cross-sectional study using an interviewer-administered and structured questionnaire was conducted. The study population consisted of students of the selected department between November, 2018 and June, 2019. A simple random sampling method technique was used to select 420 students. Bi-variate and multi-variate logistic regression analysis was performed.ResultsThe knowledge level of the respondents was 16.4%. The majority of students 205 (51%) were in the age group &lt; 20 years. Male [AOR: 1.46, 95% CI: 1.09–1.95]; coming from urban areas [AOR: 2.11, 95% CI: (1.02–4.37)]; provision of sexuality education or lecture in departments [AOR: 1.39, 95% CI: 1.02–1.91] and discussion about reproductive health with anyone else [AOR: 2.31, 95% CI: 1.48–3.62] were significant association for the knowledge of sexual and reproductive health rights.ConclusionsRespondents' knowledge level was found to be very low. Therefore, strengthening students' lectures or education on reproductive health in the curricula of high school, encouraging discussions with parents, and anyone might improve the knowledge toward sexual and reproductive health rights.
Assessment of Health Indicators in Individuals with Intestinal Stoma using the Nursing Outcomes Classification: A Cross-Sectional Study
Authors: Moya-Muñoz Noelia , Armenteros-Fernández Elena , Bautista-Mártir Clara , Vílchez-Díaz Irene Del Pilar , López-Medina Isabel María , Montoya-Juárez Rafael , Hueso-Montoro César , Capilla-Díaz Concepción 
Published: May 2022

AimTo determine nursing outcomes in individuals with intestinal stoma and the relationships between them and sociodemographic and clinical variables.DesignCross-sectional study performed with 102 subjects at the General Surgery Unit of a first-level hospital.MethodsData on the presence of nursing outcomes were collected using the Nursing Outcomes Classification. Data on sociodemographic and clinical variables were also collected. Univariate and bivariate data analyses were performed.ResultsOutcomes related to participation in making health decisions and knowledge of ostomy care were assessed across the study sample. Period of care (post-operative and follow-up) was the most common significant variable (p &lt; 0.05) among the outcomes. The outcome scores ranged from 2 to 3, indicating a moderate level of impairment in the physical, psychological, and social spheres of these patients. The scores in the indicators on Participation in making health decisions and Knowledge of stoma care improved in the period of continuity of care compared to the postoperative period, being this difference statistically significant (p &lt; 0.001).ConclusionsThe care plan for individuals with intestinal stoma needs to include indicators measuring patient participation in making decisions related to their condition, as well as indicators related to their knowledge and self-care of their stoma. Relevance to clinical practice: This study aims to determine the nursing outcomes in individuals with intestinal stoma and the relationships between them and sociodemographic and clinical variables. It provides the opportunity to plan achievable objectives with patients using a system of indicators that facilitate their assessment and monitoring.
A Case Report of Multiple Gastrointestinal Stromal Tumors: Imaging Findings, Surgical Approach, and Review of the Literature
Authors: Tarallo Mariarita , Carruezzo Cristina , Dentice Di Accadia Filippo Maria , Del Gaudio Antonella , Caruso Damiano , Polici Michela , Crocetti Daniele , Costi Umberto , Polistena Andrea , Panzuto Francesco , Laghi Andrea , Cavallaro Giuseppe , Fiori Enrico 
Published: May 2022

IntroductionMultiple gastrointestinal stromal tumors (GISTs) are rare tumors. Differential diagnosis between metastatic and multiple GISTs represents a challenge for a proper workup, prediction prognosis, and therapeutic strategy.Case presentationWe present the case of 67-year-old man with computed tomography (CT) evidence of multiple exophytic lesions in the abdomen, reaching diameters ranging from 1 to 9 cm, without any signs of organs infiltration, and resulting positive at 18F-FDG-PET/CT. Laparoscopic biopsy revealed multiple GISTs, and surgical resection by using an open approach was performed to achieve radicality. Moreover, an extensive review of the current literature was performed.ResultsSmall GISTs (&lt;5 cm) can be treated by the laparoscopic approach, while in the case of large GISTs (&gt;5 cm), tumor location and size should be taken into account to reach the stage of radical surgery avoiding tumor rupture. For metastatic GISTs, Imatinib represents the first choice of treatment, and surgery should be considered only in a few selected cases when all lesions are resectable.ConclusionSporadic multiple GISTs are a rare event, imaging findings are not specific for GISTs, and biopsy requires a secure diagnosis and proper management. In the case of large lesions, with a high risk of vessels injury, laparotomy excision should be considered to achieve radicality and to avoid tumor rupture.
Exposure to Low Doses of Oxybenzone During Perinatal Development Alters Mammary Gland Stroma in Female Mice
Authors: Matouskova Klara , Bugos Jennifer , Schneider Sallie S. , Vandenberg Laura N. 
Published: May 2022

Mammary stroma is a prominent modulator of epithelial development, and a complex set of interactions between these tissue compartments is essential for normal development, which can be either permissive or restrictive in tumor initiation and progression. During perinatal development, exposures of mice to oxybenzone, a common UV filter, environmental pollutant and endocrine disruptor, induce alterations in mammary epithelium. Our prior research indicates that oxybenzone alters mammary epithelial structures at puberty and in adulthood. We had also previously observed changes in the expression of hormone receptors at puberty (e.g., oxybenzone induced a decrease in the number of epithelial cells positive for progesterone receptor) and in adulthood (e.g., oxybenzone induced a decrease in the number of estrogen receptor-positive epithelial cells), and increased body weight in adulthood. Here, we investigated mammary stromal changes in BALB/c animals exposed during gestation and perinatal development to 0, 30, or 3000 μg oxybenzone/kg/day. In mice exposed to 30 μg/kg/day, we observed morphological changes in adulthood (e.g., a thicker periductal stroma and adipocytes that were considerably larger). We also observed an increased number of mast cells in the mammary stroma at puberty which may represent a transient influence of oxybenzone exposure. These results provide additional evidence that even low doses of oxybenzone can disrupt hormone sensitive outcomes in the mammary gland when exposures occur during critical windows of development, and some of these effects manifest in later life.
Pericardial Effusion Due to Trichosporon japonicum: A Case Report and Review of the Literature
Authors: Menu Estelle , Kabtani Jihane , Roubin Johanna , Ranque Stéphane , L’Ollivier Coralie 
Published: May 2022

Invasive infections due to Trichosporon spp. are life-threatening opportunistic fungal infections that may affect a wide array of organs. Here, we described a case of pericardial effusion due to Trichosporon japonicum in a 42-year-old female after a heart transplantation. T. japonicum was isolated from the pericardial fluid, pericardial drain hole and the swab of the sternal surgery scar wound. The late mycological diagnosis due to blood culture negative, the ineffective control of pulmonary bacterial infection and the late start antifungal therapy were the contributing factors in the patient’s death.
THE IMPORTANCE OF THE BASIC CURRICULUM FOR PRIMARY SCHOOL TEACHERS’ WORK: NATIONAL AND EUROPEAN PERSPECTIVES
Authors: Yanitska-Panek T. 
Published: May 2022

The article emphasizes that since 1999 Poland has been using the core curriculum, which is a significant change in the organization of the education system and training planning in view of the reform changes associated with Poland’s accession to the European Community. This reform and other changes became the preconditions for Poland’s accession to the European Union in May 2004.
By 2017, the core curriculum had been re-approved six times by the Ministry of Education. The EU regularly updates key competencies, which require rethinking, modernizing the national core curriculum and then the curricula of educational and didactic institutions. It is proved that taking into account the principle of individualization and the needs of students with specific educational needs. It is necessary to regularly update key competencies in the curriculum.
An urgent issue is the substantiation of the teacher training concept. It is crucial to diagnose the tendencies needed to work with younger students, respond to changing demands of socio-cultural and economic development, take into account national characteristics, and update the content of education based on innovation. Since 2018, the issue of primary school teachers’ competencies formation that demonstrates the ability to systematic pedagogical activities, cooperation, production of innovations, and their use in the educational process has become relevant.
PRIMARY SCHOOL TEACHERS’ SOFT SKILLS DEVELOPMENT WHILE TEACHING PHILOLOGICAL DISCIPLINES
Authors: Braiilko Yu. , Palekha O. , Rudych O. 
Published: May 2022

The article is devoted to the topical issue of primary school teacher training in higher educational institutions. The purpose of the research is to investigate the process of developing primary school teachers’ soft skills in the process of teaching philological disciplines.
After a comparative analysis of the definitions of the category ‘soft skills’ proposed by Ukrainian and foreign researchers, the authors have emphasized that soft skills are especially crucial for primary school teachers. Researchers have noted that to form and develop soft skills effectively during lectures and practical classes it is necessary to use different ways of interaction, namely games, case studies, colloquia, and individual and group projects.
PRELIMINARY REMARKS ON WRITING FOR INCLUSION: EUROPEAN COOPERATIVE WORK BETWEEN PRIMARY SCHOOLS WITH ETWINNING AND DIGITAL STORIES
Authors: Canals-Botines M. , Medina-Casanovas N. 
Published: May 2022

The article deals with European Cooperative Work between Primary Schools with eTwinning and Digital Stories. The author characterizes The Key Action 2 Erasmus project ‘Writing for Inclusion’ (WIN) is to focus on rising awareness, changing perceptions and providing resources to implement inclusion through the concept of Care in Education.
The main purpose of this project is to empathize with the feelings and emotions felt by those kids entering the group for the first time or those others being different form the standardized group. Opening their minds and broadening pupils’ boundaries may be a solid tool to create a more inclusive and fair society to all.
The article includes detailed description of background and goals of the project, it names all the project partners, project target groups, specific aims.