bluuebunny/crossref_metadata_2025_split huggingface dataset:
Khảo sát tình trạng sức khỏe mẹ và con ở hai nhóm sinh ngã âm đạo và mổ lấy thai tại tỉnh Cà Mau năm 2021
Authors: Nguyễn Thể Tần , Huỳnh Ngọc Linh 
Published: October 2022

Đặt vấn đề: Nhiều nghiên cứu trên thế giới và Việt Nam cho thấy tỉ lệ mổ lấy thai ngày càng tăng. Tình trạng này có thể ảnh hưởng đến sức khỏe mẹ và con về sau.
Mục tiêu nghiên cứu: Đánh giá tình trạng sức khỏe của mẹ và con giữa 2 nhóm sinh ngã âm đạo và sinh mổ sau 2 - 5 năm.
Đối tượng và phương pháp nghiên cứu: Nghiên cứu mô tả cắt ngang trên 840 bà mẹ và con tại tỉnh Cà Mau năm 2021.
Kết quả: Một số tình trạng của mẹ ở nhóm sinh mổ đều lớn hơn nhóm sinh ngã âm đạo như: thiếu sữa mẹ trong 6 tháng đầu: 59,06% so với 40,95%; thời gian cai sữa dưới 12 tháng: 36,72% so với 28,38%; đau lưng: 38,21% so với 22,2%; sẩy thai: 24,07% so với 16,93%; mổ lấy thai trong lần mang thai sau: 91,14% so với 39,33%; kinh nguyệt không đều: 24,07% so với 15,79%; đau bụng khi hành kinh: 30,52% so với 20,36%; với p < 0,05. Đối với con so sánh ở hai nhóm sinh mổ và sinh ngã âm đạo, tình trạng béo phì: 22,58% so với 14,42%; khò khè: 40,69% so với 28,6%; dị ứng da: 22,08% so với 13,27%; khám bệnh nhiều lần: 38,46% so với 22,2%; số lần nhập viện nhiều: 20,84% so với 13,04%; p < 0,01.
Kết luận: Tỉ lệ thiếu sữa trong 6 tháng đầu, đau lưng, rối loạn kinh nguyệt, sảy thai, mổ lấy thai khi mang thai lần sau…ở nhóm sinh mổ cao hơn nhóm sinh ngã âm đạo. Con của bà mẹ sinh mổ dễ bị thừa cân béo phì, dị ứng da, khò khè, khám bệnh và nhập viện nhiều hơn nhóm bà mẹ sinh ngã âm đạo.
Một số yếu tố liên quan đến kết quả chăm sóc trẻ được điều trị surfactant tại Trung tâm Sơ sinh Bệnh viện Phụ sản Trung ương năm 2020 - 2021
Authors: Ngô Hồng Vân , Lê Minh Trác , Dương Lan Dung 
Published: October 2022

Mục tiêu: Phân tích một số yếu tố liên quan đến kết quả chăm sóc trẻ sơ sinh non suy hô hấp được điều trị surfactant tại Trung tâm Chăm sóc và Điều trị Sơ sinh Bệnh viện Phụ sản Trung ương năm 2020 - 2021.
Đối tượng và phương pháp nghiên cứu: Nghiên cứu mô tả cắt ngang trên 200 trẻ sơ sinh non dưới 37 tuần suy hô hấp được điều trị surfactant tại Trung tâm Chăm sóc và Điều trị Sơ sinh - Bệnh viện Phụ sản Trung ương trong thời gian nghiên cứu từ tháng 11/2020 đến tháng 06/2021. Số liệu được quản lý bằng phần mềm Epidata 3.1 và được phân tích bằng phần mềm Stata 15.
Kết quả: Chăm sóc tốt chiếm 80,5% và chưa tốt là 19,5%, biến chứng xuất huyết phổi chiếm tỷ lệ cao nhất 12%, tuổi thai từ 32 - < 37 tuần chăm sóc tốt gấp 4,54 lần so với nhóm < 32 tuổi, cân nặng từ 1000 g đến dưới < 2500 g chăm sóc tốt gấp 10,13 lần so với nhóm < 1000 g, Silverman 4 - 6 điểm chăm sóc tốt gấp 1,31 lần so với nhóm > 6 điểm, nhóm trẻ không có biến chứng chăm sóc tốt hơn 4 - 6 lần nhóm có biến chứng, các đặc điểm của mẹ ảnh hưởng nhiều đến kết quả chăm sóc trẻ (p < 0,05).
Kết luận: Những yếu tố liên quan đến kết quả chăm sóc có ý nghĩa thống kê bao gồm: tuổi thai, cân nặng, chỉ số Silverman, biến chứng và một số đặc điểm của người mẹ.
Relasi Perwakilan, Pemilihan dan Voting dalam Penyelenggaraan Demokrasi di Indonesia
Authors: Sumardi Sumardi , Purnomo Eko Prio 
Published: October 2022

This paper aims to analyze the practice of political administration in Indonesia with various models and democratic systems that are applied. Using descriptive qualitative analysis with literature review. Through comparison of Model Selection, Representative and Voting. Democracy held through election celebrations general periodicity actually becomes the foundation and umbrella for its creation development of culture and improvement of community welfare and interests general. However, the process tends to indicate that it is just a place to find form and very difficult to adjust. Between Representatives, Elections and Voting exist ideal democracy seems to be an anomaly in the realization of the quality of democracy. The implications are diverse, political parties thrive not in direct proportion to the quality of state policies, strengthening the existence of elite power without caring for common sense government administrators as state control. Finally comes the distribution of power who have no public trust.
A comprehensive study of Urvi Marma - The vital point mentioned by Acharya Sushruta
Authors: Jungade Leena G , Shelke Dinbandhu S , Bathe Anupama M , Chandurkar Nitin S , Kalangutkar Dipti D 
Published: October 2022

Marma science (traumatology) is a unique specialty of Ayurveda that plays a significant role in surgical procedures and treatments. Acharya Sushruta has described Urvi Marma as part of the Sira marma (a vital point which is vascular in nature), and he has mentioned the traumatic disorders associated with it. In order to apply Acharya Sushruta's invaluable knowledge of Urvi Marma in the current era, it is necessary to precisely correlate his concept of Urvi Marma with present Anatomical perspectives. This research aims to bridge the gap between old wisdom and current science. Material and Methods: A comprehensive review of the literature on the concept of Marma Sharir (traumatology) and Urvi Marma was conducted, taking into account the position of Urvi Marma as told by our ancient experts. The anatomy of the thigh, as well as its application, has been researched through numerous books and dissection.
Standardization of Dooshivishahari Agada through HPTLC
Authors: P Deepa , H R Nataraj , H N Prajwal , C G Anushree 
Published: October 2022

Ayurveda medicines are a time-tested and valuable resource for healing, even today, globally. Hence the quality control standards for the Ayurvedic formulations is the need of time because of commercialization. Despite the availability of modern equipment and techniques, not all Ayurvedic formulations have been standardized as per modern day protocol. Dooshivishari agada (DVA), a herbo-mineral preparation; mentioned in the text of Asthangha hrudaya in the context of treatment of poisoning, specifically for dooshivisha (cumulative poison). High-performance thin-layer chromatography (HPTLC) is a validated analytical tool for qualitative and quantitative analysis of chromatographic information. In this present study, an effort has been made to standardize DVA through HPTLC. HPTLC photo documentation of DVA showed 8, 11, and 10 spots under short UV, long UV, and under white light after derivatization respectively. Densitometric scan at 254 nm revealed 3 high peaks corresponding to 3 different compounds in the ethanol extract, compounds, at 366 nm and 620 nm there were three high peaks. These Physico-chemical constants, TLC photo documentation, the unique Rf values, and densitogram obtained at different wavelengths can be used as a fingerprint to identify DVA.
Association of Viharaj Hetus (External and Environmental Factors) with Shirahshool (Headache) – A cross sectional study
Authors: Sanghmitra Randhir , Vinayak Joshi Mrudula , Nilkanth Joshi Vinayak 
Published: October 2022

Background- Shirahshool (headache) encompasses all the aches and discomforts associated in the Shira(head) region and is described under the caption of Shiroroga in Ayurveda texts. Aharaj (diet related) and Viharaj (external and environmental) Hetus are the main causative factors for any disease; yet the external and environmental factors also play an important role in Shirahshool. Aim-To observe the role of Viharaj Hetus for their association with Shirahshool .Study Design-This cross sectional study was conducted amongst the pre diagnosed Shirahshool patients, both male and females from the age group 20-60 years, who were suffering for more than one year and get Shirahshool for more than 30 minutes every time. A structured, pilot tested questionnaire with 15 questions validated by scientific committee was used to collect the information. Statistical analysis- The collected data is qualitative Pearson correlation test and Chi square test is used to test the association between Viharaj Hetus and Shirahshool. P- Value less than 0.05; which was considered as significant association. Result- Amongst Viharaj Hetus, Shita Vayu Sewan (cold air exposure-external environmental factor) was present in maximum number of patients i.e. 40 %, Nidra Vega Vidharana (suppression of the urge for sleep) in 36%, Asatmya Gandha Sewan(bad odour) in 31 % of total Shirahshool patients. Conclusion- The highest incidence of Shiroroga based on chronicity (59%) is in between 1-5 years with the duration for 30-60 minutes and based on severity 46% with moderate grade of Shirashool. Exposure to cold air and suppression of urge for sleep are the causative factors found as important with respect to duration of exposure whereas anger was noted as major, immediate Hetu of Shirahshool. Thus the association of Viharaj hetus with Shirahshool is of very much importance with respect to diagnosis, prevention and treatment
Understanding of Post Covid Mucormycosis through the Lens of Ayurveda
Authors: Bathe Anupama M , Thanvi Harsha , Dipankar Digambar , Jungade Leena , Varghese Jibi , Mane Pallavi 
Published: October 2022

Mucormycosis is fungal disease caused by fungus Mucor. It has been seen as a life-threatening complication of disease Covid-19. It has 70 times higher prevalence rate in India as compared to the world, having only few but expensive treatment options. The triggers of Mucor infection in Covid-19 patients are immune deficiency and hyperglycaemia caused by the use of corticosteroid, which favours Mucorales tissue Penetration. Mucormycosis has mainly six different types viz pulmonary, rhino-orbital-cerebral, gastrointestinal, widely disseminated, cutaneous, & miscellaneous infection, the commonest clinical presentation is rhino-orbito-cerebral in Covid-19 pandemic.
Ayurveda though an ancient science of healing, has strength to treat newer diseases from several decades. Mucormycosis disease is not mentioned in Ayurveda text directly, it is Un uttered disease (Anukta Vyadhi) but it can be treated with help of basic principles of Ayurveda. By understanding the pathogenesis, it can be stated that, it is an Abhishangaja Vyadhi (diseased caused by Virus/ Bacteria/ Parasite) and categorised as Raktapitta Pradhan Tridoshaja Vyadhi (disease caused by vitiation of all three humors with rakta pitta predominance).
Prevention of Mucormycosis can be achieved by following daily (Dincharya) and seasonal (Ritucharya) regimens. The treatment protocol include Krimighna (Antimicrobial), Tridoshashamak (normalise all three humors) and Raktashodhaka /Pittashamak (blood purifier), Agnideepak (improve digestion) & Aampachak (improve metabolism), Pramehhar (treatment of diabetes/hyperglycaemia) and Rasayana (Rejuvenation) drugs.

Key words- Abhishangaj vyadhi, Anukta Vyadhi, Mucormycosis , RaktaPitta Pradhan Tridoshaj Vyadhi
Pharmaceutico analytical study of Guduchyadi Avaleha - Modified form of Guduchyadi Ghrita
Authors: Rudey Megha , Rathi Renu , Rathi Bharat 
Published: October 2022

Introduction- Stuttering (Gadgada) word itself indicates the disease in which fluency of speech is impaired. It denotes the un-cleared speech (Avyakta Vak or Shabdha). In Vangsen Samhita, the group of 8 drugs with honey is cited for the treatment of stuttering entitled as Guduchyadi Ghrita. Palatability of Guduchyadi Ghrita is the major concern in the treatment of children to administer as most of children unlike it, so by keeping this in mind Avaleha formulation is prepared which is easily administrable. Guduchyadi Avaleha is a herbo-mineral confection which is prepared by using sugar as a base. This herbal compound is formulated by experienced Aacharya of Ayurved and is used in practice for stuttering. Though it’s a potent formulation; but no standardized reports are available for the manufacturing process of the Guduchyadi Avaleha or its preliminary physico-chemical profiles. Therefore, manufacturing standardize process of preparation and preliminary physic-chemical profiles of Guduchyadi leha was planned. Methods- The prepared lickable formulation was lay open for the analysis of pharmacognostical and pharmaceutical properties like as pH value, Microscopic analysis, loss on drying the sample, reading of ash value, etc. Results – After analysis of Pharmacognostical organoleptic study, loss on drying value, pH, Ash value, Water soluble extract, the result was shown. Conclusion –All the characteristic of formulation sample was observed and the result can be taken as standard value for guduchyadi avaleha.
Pharmaceutical development of polyherbal Kushthaghna Mahakashaya lotion with FTIR and HPTLC characterization
Authors: Pandey Shivani , R S Hiremath , V S Mannur 
Published: October 2022

Introduction: Kushthaghna Mahakashaya is a traditional herbal group of ten medicaments (dashemani) explained in classical texts and administered in the form of kashaya (decoction) indicated for the management of Kushtha (skin ailments). In the present scenario, based on disadvantages of the kashaya like lesser shelf-life, cumbersome, difficult to prepare and administer on a daily basis. Furthermore, if it is administered by an external route then, it may avoid first-pass metabolism and thereby enhancing the drug’s bioavailability and causing its rapid action. So, the present study is an attempt to prepare and analyze the modified dosage form of Kushthaghna Mahakashaya Kwatha in the form of Kushthaghna Mahakashaya Lotion. Materials and methods: Kushthaghna Mahakashaya Churna, Ghana, and Lotion were all prepared. Lotion was made by mixing the aqueous and oil phases together at the same temperature. It was stabilized with Carbopol and neutralized with Triethanolamine to improve the sample's stability. Different trials were conducted to check the excipient ratio in the formulation, and samples were evaluated according to standards. Organoleptic parameters, physico-chemical analysis, FTIR, HPTLC, and microbiological specification tests were all performed on the Ghana and Lotion. Results: All the tests and observations were carried out on Kushthaghna Mahakashaya Ghana and Lotion samples, and the results were recorded. Conclusion: Kushthaghna Mahakashaya Lotion can be prepared from Kushthaghna Mahakashaya Kwatha. The prepared lotion will be light brown in colour, characteristic smell and semi-liquid in consistency with good spreadibility.
Study of combined effect of Khadirashtak kwath and Lodhradi lep on Mukhdushika (Acne Vulgaris) – A pilot study
Authors: Deshpande Amol , Deshpande Mayuri Amol , Desai Priti 
Published: October 2022

Introduction: Skin is one of the five Gyanendriyas (Sense organ) as described in Ayurvedic texts. It is responsible for Sparshdyanam, hence plays important role in Physical and Mental well being. It plays the most important role by interfacing with surrounding. On contrary with this there is increased pollution, stress, change in diet, change in life style causing the most burning skin problem i.e. Mukhdushika so called Acne Vulgaris. In modern science most of the drug which are used have side effect and complications on long term used, so Ayurveda is an best option to treat the diseases. Lodhradilep mentioned in Samhita can be used for external application and Khadirashtak kwath can be used for internal application. It can be used as alternate therapy which is devote of complication and side effect. Aim: To evaluate the efficacy of Lodhradi lep and Khadirashtak kwath on Mukhdushika. Objectives: To study the effect of Lodhradi lep and Khadirashtak kwath on Mukhdushika. Methodology: Ten patients of Mukhdushika (acne) were enrolled into this pilot study. All patients were evaluated on the basis number of Pidikas (acne), Area Occupied, Kandu (itching), Srava (secretions), Vedana (pain). After 28 days of administration of Lodhradilep and Khadirashtak Kwath twice in a day after meal; result was analysed by paired t test. Results and conclusions: The result in all symptoms i.e. number of Pidikas (acne) (P = <0.001), Area Occupied(P = 0.001), Kandu (itching) (P = <0.001), Srava (secretions) (P = <0.001), Vedana (pain) (P = <0.001)) was found statistically significant. Thus Lodhradi lep and Khadirashtak Kwath on Mukhdushika is an effective combination for management for Mukhdushika.
Phytochemical analysis of Clerodendron infortunatum Linn. leaves in various seasons by different solvent and extraction techniques
Authors: Changade Jayshree  V , Thomas Asha , Tanvi Harsha A , Ghangale Nilima , Shirkande Abhijeet , Sable Poonam Dilip 
Published: October 2022

Clerodendron infortunatum Linn is widely used for the treatment of malaria and vermifuge, scorpion and snake bites, tumors, inflammation, bronchitis and in wound healing. The present study was carried out to estimate the variation in the amounts of Gallic acid, Rutin and Quercetin in Clerodendron infortunatum Linn.leaves extracts collected in different seasons using high-performance thin layer chromatography (HPTLC).In this study, leaves of C. infortunatum were subjected to methanol extractions using Soxhlet method and cold maceration. The leaves were collected in different seasons in the months of December (Sample A -Shishir rutu-Winter season) and July (Sample B -Varsha Rutu -Rainy season). The methanolic extracts were subjected to HPTLC study & using CAmag HPTLC system, employing a mixture of toluene:ethyl acetate:formic acid:methanol(3:6:1.6:0.4 ) as the mobile phase with densitometric scanning at 254nm. Quantity of Quercetin is found in both samples, extracted by Soxhlet method. Its quantity is higher in the winter season. Quantity of Gallic acidis found in both samples. Its quantity is the same in Sample B by Soxhlet extraction method & maceration method respectively. Quantity of Rutin is found in both the samples extracted by Soxhlet & maceration methods. It is higher in the sample-A. The present HPTLC method is used for the detection and quantization of Gallic acid, Quercetin and Rutin of C. infortunatum leaves. It needs to study the season wise and region wise variation of phytochemicals in useful parts of all other plants by different extraction methods.
Pharmaceutico-Analytical study of Karaviradya taila
Authors: Benjarwad Ashwini , Kadibagil Vinaykumar R , K Govinda Sharma , Sanagala Priyanka , Kamatar Sangeeta B , Gowda Srusti K 
Published: October 2022

Introduction: Sneha kalpana (oleaginous preparations) is commonly prescribed Ayurvedic dosage form and it is the preparation of various kinds of medicated oils and ghee. Karaviradya taila is medicated oil preparation used externally in the form of abhyanga (massage) for lomashatana (depilation). Objectives: To prepare and carry out the physico-chemical analysis of karaviradya taila. Materials and Methods: Karaviradya taila was prepared by general method of taila kalpana i.e ¼:1:4 and analytical study like organoleptic characters and physico- chemical parameters were carried out based on the references available in the laboratory guide for the analysis of Ayurveda and Siddha formulation. Results and Discussion: The total oil obtained was 85% and the loss was 15%. Organoleptic characters of karaviradya taila showed translucent green viscous liquid with alkaline odor, Physico- chemical parameters like pH, specific gravity, viscosity, total suspended solids, and refractive index were tested. The increased Saponification value of karaviradya taila indicates the rate of absorption, low acid value of karaviradya taila indicates less chance of decomposition of taila. Evaporation of moisture contents in karaviradya taila leads to the decrease in rancidity factors. Peroxide value and iodine value of karaviradya taila indicates the primary oxidation. Conclusion: Karaviradya taila is a sneha kalpana mainly indicated for loma shatana (depilation). Local applications is beneficial because they are quickly absorbable, protect the skin and promotes percutaneous absorption of incorporated drug. The results of pharmaceutical and analytical study of karaviradya taila can be considered as the preliminary standards for the preparation of karaviradya taila.

Keywords: Lomashatana, Karaviradyataila, Bahirparimarjana chikitsa, Sneha kalpana, Depilation, Hair Removal.
Acute toxicity study of the nanoparticles of Bauhinia variegata Linn bark hydro-alcoholic extract in Wistar Albino rats
Authors: Choudhary Yakshi , Deshpande Shailesh V , Patil Sandeep B , Chaudhari Atul L 
Published: October 2022

Background: Bauhinia variegate Linn is a popular herb used as medicine in traditional health sciences in Southeast Asia. Traditional medicines if used in newer dosage forms such as nanoparticles, can help in reducing the dose, assuring quality, and reducing exploitation of natural resources. However, the safety of medicines needs to be established before use in humans.
Objective: To evaluate the acute toxicity of nanoparticles of Bauhinia variegate Linn bark hydro-alcoholic extract (NBVBE) in Wistar Albino rats on the basis of OECD guidelines 423.
Methodology: The study was conducted using six Wistar albino rats divided into two groups of three rats each. Test rats were given a single dose of 2000 mg/kg body weight of NBVBE orally, while the control group received feed and water ad libitum.
Results: The data indicated no significant changes in weight, complete blood count, or renal and hepatic function when compared with control (p > 0.05). Histopathological examination shows some reversible changes such as steatosis and lymphoid hyperplasia in the rat’s liver and intestine. LD50 for NBVBE is higher than 2000 mg/kg body weight.
Conclusion: NBVBE is safe at 2000 mg/kg body weight. However, monitoring the status of the liver is necessary.
Role of Kushmand Paak in treating Male Infertility
Authors: Gaikwad Bhim , Jibi Varghese , Yeola Gunvant , DG Dipankar , Taware Smritika , Patil Aboli 
Published: October 2022

ABSTRACT:
Objectives: To evaluate the efficacy of Ayurvedic herbal drug combination as a good and effective ability treatment on sperm production without any side effects on prolonged use.
Materials & methods: It was a self-control clinical trial study. In this study, we enrolled 40 patients having complaints of infertility. of age 25-40 years married for not less than 3 years. All these participants were advised to take 30 g of Kushmand Pak after mid meals with a cup of warm milk for 3 months. Sperm count, semen color, viscosity, and state were recorded before starting the treatment and after 3 months of completion of treatment.
Results: It was observed that ‘Kushmand Pak’ was accepted by all with no complaints about any side effects. Viable, active, and morphologically perfect sperm count was also increased to a significant level.
Conclusion: Kushmand Pak can be used to improve sperm count without any side effects on prolonged use.
Keywords: Male infertility, herbal drugs, Kushmand Pak
Simultaneous method development and validation of 1, 8-Cineole and Betulinic acid in Shati Vati - An Ayurvedic formulation by HPTLC
Authors: Joshi Krupa , Patel Jaya , Raskar Swapnil , Aghara Chandani 
Published: October 2022

A simple, accurate and precise HPTLC method was developed and validated for simultaneous estimation of 1, 8-Cineole and Betulinic acid in Shati Vati - An Ayurvedic formulation by HPTLC. Shati Vati contains Shati rhizome powder have 1-8 cineole and Badar ripe fruit powder have Betulinic acid reported medicinal claims and uses. In the analytical method, toluene: ethyl acetate (93:07 v/v) was finalized as the mobile phase and a clear separation was achieved. The wavelength for 1-8 cineole and Betulinic acid was 665nm and 580nm respectively. The Rf value of 1-8 cineole and betulinic acid was obtained 0.647 and 0.213 respectively. The developed analytical method was validated for Linearity, Accuracy, Precision, LOD, LOQ and Robustness as per ICH Q2 (R1) guideline. Results for the validation process were within the range of acceptance criteria of ICH guideline. HPTLC method have been applied successfully for estimation of 1-8 Cineole and Betulinic acid in Shati Vati an ayurvedic formulation.