bluuebunny/crossref_metadata_2025_split huggingface dataset:
Leptin differentially regulate cell apoptosis and cycle by histone acetylation in tibial and vertebral epiphyseal plates
Authors: Li Xiaomiao , Fu Xiaodong , Li Hao , Gao Yingjian , Wang Weili , Shen Yi 
Published: December 2022

AbstractLeptin showed different apoptosis regulation effects on the chondrocytes from tibial and vertebral epiphyseal plates. However, the mechanism is still unclear. In this study, we tested the protein profile of tibial and vertebral epiphyseal plate chondrocytes with and without leptin stimulation by mass spectrometry and found that the histone acetylation level of tibial chondrocytes was decreased after leptin treatment, while increased in vertebral epiphyseal plates. COIP assay showed that leptin promoted H3, H4 histone acetylation by recruiting CREB binding protein (CBP)/P300 to activate histone acetyl transferases (HATs) activity in vertebral disc chondrocytes. But in tibial plate cartilage cells, leptin did not recruit CBP and p300, thus differently affect the apoptosis of epiphyseal plate chondrocytes. Through explored the mechanism of histone acetylation modulated by leptin, and its effect on cartilage cell apoptosis and cell cycle regulation, This provides a novel target therapy possibility therapeutic approach to for the related disease.
MOF‐derived NiCo‐LDH Nanocages on CuO Nanorod Arrays for Robust and High Energy Density Asymmetric Supercapacitors
Authors: Bi Qiong , Hu Xuanying , Tao Kai 
Published: December 2022

AbstractLayered double hydroxide (LDH) is widely explored in supercapacitors on account of its high capacity, adjustable composition and easy synthesis process. Unfortunately, solitary LDH still has great limitations as an electrode material due to its shortcomings, such as poor conductivity and easy agglomeration. Herein, nanoflakes assembled NiCo‐LDH hollow nanocages derived from a metal–organic framework (MOF) precursor are strung by CuO nanorods formed from etching and oxidation of copper foam (CF), forming hierarchical CuO@NiCo‐LDH heterostructures. The as‐synthesized CuO@NiCo‐LDH/CF shows a large capacitance (5607 mF cm−2 at 1 mA cm−2), superior rate performance (88.3 % retention at 10 mA cm−2) and impressive cycling durability (93.1 % capacitance is retained after 5000 cycles), which is significantly superior to control CuO/CF, CuO@ZIF‐67/CF, NiCo‐LDH/CF and Cu(OH)2@NiCo‐LDH/CF electrodes. Besides, an asymmetrical supercapacitor consists of CuO@NiCo‐LDH/CF and activated carbon displays a maximum energy density of 47.3 Wh kg−1, and its capacitance only declines by 6.8 % after 10000 cycles, demonstrating remarkable cycling durability. The advantages of highly conductive and robust CuO nanorods, MOF‐derived hollow structure and the core‐shell heterostructure contribute to the outstanding electrochemical performance. This synthesis strategy can be extended to design various core‐shell heterostructures adopted in versatile electrochemical energy storage applications.
The research on channel estimation and signal‐noise ratio estimation based on minimum error entropy kalman filter for single carrier frequency domain equalization system
Authors: Dong Pengyu , Xiang Xin , Liang Yuan , Wang Peng , Wang Rui 
Published: December 2022

SummaryIn this paper, the channel estimation and signal‐to‐noise ratio (SNR) estimation technique of single‐carrier frequency domain equalization (SC‐FDE) system under low SNR in aeronautical multipath channel are studied, a SNR estimation algorithm which is easy to implement in engineering and an improved LS channel estimation algorithm based on Kalman filter using minimum error entropy (MEE‐KF) are proposed. This paper first introduces the SC‐FDE system and introduces the principle of MEE‐KF, and then, the channel estimation flow based on MEE‐KF is obtained by combining it with the traditional LS channel estimation algorithm, which makes the estimation results perform better. Simulation results show that after getting more accurate noise variance, the channel estimation results can better follow the changes of the channel after MEE‐KF processing, so as to resist the doppler frequency offset effect and make the channel estimation results more accurate, that is the channel response results of the data part can be closer to the real situation, so that the communication performance of SC‐FDE system has also been greatly improved.
Berberine up‐regulates miR‐340‐5p to protect myocardial ischaemia/reperfusion from HMGB1‐mediated inflammatory injury
Authors: Long Tianyi , Pan Wei , Li Fei , Sheikh Sayed Ali , Xie Qiying , Zhang Chenglong 
Published: December 2022

AbstractAimsMyocardial ischaemia/reperfusion injury (MIRI) is a major cause of heart failure after myocardial infarction. Berberine (BBR) presents anti‐inflammatory and immunosuppressive properties in many diseases. Our research looked into the therapeutic effects and mechanism of BBR in MIRI.Methods and resultsMIRI animal and cell models were established. The mRNA and protein expressions were assessed using reverse transcription and quantitative real‐time polymerase chain reaction and western blot. The haemodynamic parameters (left ventricular ejection fraction and left ventricular ejection fraction) were detected by echocardiography. The myocardial infarct size and myocardium lesion were assessed by triphenyltetrazolium chloride and haematoxylin–eosin staining. The levels of injury factors were determined by ELISA. Terminal deoxynucleotidyl transferase‐mediated dUTP nick‐end labelling staining was performed to analyse cell apoptosis. Dual luciferase reporter gene and RNA immunoprecipitation assays were carried out to verify the interaction between miR‐340‐5p and HMGB1. BBR administration could improve the haemodynamic parameters and infarct size in MIRI rats (all P < 0.05). In MIRI rat model, BBR reduced cardiomyocyte apoptosis and inflammation (all P < 0.05). BBR could promote miR‐340‐5p expression (0.64 ± 0.21, P < 0.05), which is lowly expressed in MIRI group (0.24 ± 0.10, P < 0.01) in compare with the sham group (0.99 ± 0.01). MiR‐340‐5p knockdown abolished the protective effects of BBR on H/R‐treated cardiomyocytes (all P < 0.05). BBR suppressed the HMGB1/TLR4/NF‐κB pathway activation in MIRI. HMGB1 functioned as the target of miR‐340‐5p, and its silencing reversed the effect of miR‐340‐5p inhibitor on BBR‐treated MIRI.ConclusionsIn MIRI, BBR repressed HMGB1‐mediated TLR4/NF‐κB signalling pathway through miR‐340‐5p to suppress cardiomyocyte apoptosis and inflammation.
Power system short‐term voltage stability assessment based on improved CatBoost with consideration of model confidence
Authors: Zhu Ruijin , Ciren Gesang , Tang Bo , Gong Xuejiao 
Published: December 2022

AbstractWith the intensive commissioning of high voltage direct current, transient voltage problems have become increasingly prominent, which seriously threatens the safe and stable operation of the power system. On the basis of cascaded CatBoost (CasCatBoost) and sparrow search algorithm (SSA), a novel temporal‐adaptive data‐driven method for short‐term voltage stability (STVS) assessment is proposed in this paper. First, normalized mutual information feature selection is employed for important feature selection to reduce the computational burden. Taking the important features as inputs, the CasCatBoost model is constructed to mine STVS informatization. On the basis of CatBoost and cascaded structure, CasCatBoost can enhance the assessment accuracy without sacrificing the assessment earliness. Furthermore, the SSA is embedded into the offline phases of CasCatBoost to determine the optimal confidence threshold. Extensive numerical tests are conducted on the improved New England 39‐bus system, and the simulation results demonstrate that the proposed method outperforms other representative machine learning algorithms and exhibits excellent reliability, rapidity, and applicability.
Neotypification of Phyllanthus blancoanus (Phyllanthaceae)
Authors: Chakrabarty Tapas , Kumar Anand , Bandyopadhyay Subir 
Published: December 2022

AbstractA new name, that is Phyllanthus blancoanus, was proposed by Müller Argoviensis for Blanco's P. tetrander which, in turn, is a later homonym (Art. 53.2 of Shenzhen Code) of Roxburgh's P. tetrandrus (year of publication 1845 and 1832, respectively). We accepted to treat Phyllanthus blancoanus under the genus Nymphanthus (as Nymphanthus blancoanus) according to a recent molecular data. Blanco's name is neotypified on a US specimen lacking original materials (Arts. 9.4 and 9.8 of Shenzhen Code).
New compact difference schemes on non‐uniform collocated and staggered grids for convection‐dominated flows
Authors: Yadav Vivek S. , Maurya Praveen K. , Rajpoot Manoj K. 
Published: December 2022

SummaryThis paper deals with the formulation of the tridiagonal compact difference schemes for derivatives up to second‐order with boundary stencils on non‐uniform grids. A compact scheme for the first derivative with interpolation is also devised on staggered non‐uniform grids. The developed schemes with non‐uniform spacing transform to respective classical compact schemes for the case of uniform mesh spacing. The resolution, numerical diffusion, and anti‐diffusion features of the devised schemes are evaluated using global spectral analysis. Applications to the direct numerical simulation (DNS) of two‐dimensional lid‐driven cavity (LDC) flow governed by Navier‐Stokes equations and wave‐propagation following linear rotating shallow water (LRSWE) equations with variable grid‐spacing are discussed at different choices of parameters. Computed results are also compared with solutions available in the literature.
Who has an edge in trading index derivatives?
Authors: Jang Jeewon , Kang Jangkoo , Lee Jaeram 
Published: December 2022

AbstractUsing the transaction data of a leading index derivatives market, we find that foreign institutional investors make huge profits while domestic individuals lose almost the same amount. Our empirical findings show that foreign institutional investors' profits cannot be attributed to their overnight information advantage or reward for liquidity provision. Our evidence is consistent with the hypothesis that foreign investors have superior marketwide information about intraday changes in the underlying index.
Technical approaches and challenges to study AMPA receptors in oligodendrocyte lineage cells: Past, present, and future
Authors: Perez‐Gianmarco Lucila , Kurt Begüm , Kukley Maria 
Published: December 2022

AbstractReceptors for α‐amino‐3‐hydroxy‐5‐methyl‐4‐isoxazolepropionic acid (AMPARs) are ligand‐gated ionotropic receptors for glutamate that is a major excitatory neurotransmitter in the central nervous system. AMPARs are located at postsynaptic sites of neuronal synapses where they mediate fast synaptic signaling and synaptic plasticity. Remarkably, AMPARs are also expressed by glial cells. Their expression by the oligodendrocyte (OL) lineage cells is of special interest because AMPARs mediate fast synaptic communication between neurons and oligodendrocyte progenitor cells (OPCs), modulate proliferation and differentiation of OPCs, and may also be involved in regulation of myelination. On the other hand, during pathological conditions, AMPARs may mediate damage of the OL lineage cells. In the present review, we focus on the technical approaches that have been used to study AMPARs in the OL lineage cells, and discuss future perspectives of AMPAR research in these glial cells.
Performance of visual inspection of the cervix with acetic acid (VIA) for triage of HPV screen‐positive women: results from the ESTAMPA study
Authors: Baena Armando , Mesher David , Salgado Yuli , Martínez Sandra , Villalba Griselda Raquel , Amarilla Maria Luisa , Salgado Brenda , Flores Bettsy , Bellido‐Fuentes Yenny , Álvarez‐Larraondo Manuel , Valls Joan , Lora Oscar , Virreira‐Prout Gonzalo , Figueroa Jacqueline , Turcios Elmer , Soilán Ana María , Ortega Marina , Celis Marcela , González Mauricio , Venegas Gino , Terán Carolina , Ferrera Annabelle , Mendoza Laura , Kasamatsu Elena , Murillo Raúl , Wiesner Carolina , Broutet Nathalie , Luciani Silvana , Herrero Rolando , Almonte Maribel ,   the ESTAMPA study group
Published: December 2022

AbstractVIA is recommended for triage of HPV‐positive women attending cervical screening. In the multicentric ESTAMPA study, VIA performance for detection of cervical intraepithelial neoplasia grade 3 or worse (CIN3+) among HPV‐positive women was evaluated. Women aged 30‐64 years were screened with HPV testing and cytology and referred to colposcopy if either test was positive. At colposcopy visit, study‐trained midwives/nurses/GPs performed VIA ahead of colposcopy. VIA was considered positive if acetowhite lesions were observed in or close to the transformation zone. Ablative treatment eligibility was assessed for VIA positives. Performance indicators were estimated. Three thousand one hundred and forty‐two HPV‐positive women were included. Sensitivity for CIN3+ was 85.9% (95% CI 81.2‐89.5) among women <50 years and, although not significant, slightly lower in women 50+ (78.0%, 95% CI 65.9‐86.6). Overall specificity was 58.6% (95% CI 56.7‐60.5) and was significantly higher among women 50+ (70.3%, 95% CI 66.8‐73.5) compared to women <50 (54.3%, 95% CI 52.1‐56.5). VIA positivity was lower among women 50+ (35.2%, 95% CI 31.9‐38.6) compared to women <50 (53.2, 95% CI 51.1‐55.2). Overall eligibility for ablative treatment was 74.5% and did not differ by age. VIA sensitivity, specificity, and positivity, and ablative treatment eligibility varied highly by provider (ranges: 25%‐95.4%, 44.9%‐94.4%, 8.2%‐65.3%, 0%‐98.7%, respectively). VIA sensitivity for cervical precancer detection among HPV‐positive women performed by trained providers was high with an important reduction in referral rates. However, scaling‐up HPV screening triaged by VIA will be challenging due to the high variability of VIA performance and providers' need for training and supervision.
Assessment of fetal cardiac morphology and functional changes in early‐onset and late‐onset fetal growth restriction
Authors: Oluklu Deniz , Menekse Beser Dilek , Uyan Hendem Derya , Yıldırım Muradiye , Lalelı Koc Bergen , Tanacan Atakan , Sahin Dilek 
Published: December 2022

AbstractObjectiveTo compare the fetal cardiac morphology and functions of early‐onset fetal growth restriction (EO‐FGR) and late‐onset fetal growth restriction (LO‐FGR) groups with gestational weeks‐matched controls.MethodsA total of 164 pregnant women were included, 28 of whom were in the EO‐FGR group, 54 in the LO‐FGR group, and 82 in the control group. Fetal echocardiographic evaluation was performed with two‐dimensional, M‐mode, tissue Doppler imaging (TDI), and pulsed wave Doppler.ResultsFetal cardiac morphologic measurements and diastolic and systolic functions changed in EO‐FGR and LO‐FGR fetuses compared with controls. The EO‐ and LO‐FGR fetuses had reduced right and left cardiac output, increased myocardial performance index, and significantly higher mitral and tricuspid E/E' ratios compared with controls. The EO‐FGR fetuses had lower mitral and tricuspid E and E' values. In LO‐FGR fetuses, mitral and tricuspid E' values were lower than in their controls (P = 0.001 and P < 0.001). On the other hand, the mitral and tricuspid E values were not significantly changed (P = 0.107 and P = 0.196).ConclusionWe hypothesized that EO‐FGR and LO‐FGR fetuses had insufficient myocardial maturation. Especially in the LO‐FGR fetuses, TDI is the earliest and most sensitive technique to show subtle changes in fetal cardiac functions.
Prediction of high‐risk factors for ovarian metastasis in patients with endometrial cancer: A large‐sample retrospective case–control study
Authors: Li Qian , Zhang Xin 
Published: December 2022

AbstractObjectiveTo determine the high‐risk factors of ovarian metastasis of endometrial cancer and their impact on prognosis.MethodsA retrospective case–control study was conducted on a large cohort of patients with endometrial cancer.ResultsA total of 1240 patients with endometrial cancer were eligible for analysis, of whom 120 (9.7%) had ovarian metastasis. The patients with endometrial cancer with ovarian metastasis were more likely to have deep myometrial infiltration, lymph node metastasis, and elevated levels of CA125. The median survival was 39 months in patients with ovarian metastasis and 111 months in those without ovarian metastasis (P < 0.001). According to the stratified analysis, the progression‐free survival (PFS) and overall survival in the low‐risk group and PFS in the high‐risk group of patients with endometrial cancer with ovarian metastasis were significantly shorter than those without ovarian metastasis (P < 0.0001, P = 0.0034, and P < 0.0001, respectively).ConclusionDeep myometrial invasion, lymph node metastasis, and elevated levels of CA125 may be independent high‐risk factors for ovarian metastasis in patients with endometrial cancer. Ovarian metastasis has a greater impact on the prognosis of patients with low‐risk endometrial cancer.
Multimodal brain tumor detection and classification using deep saliency map and improved dragonfly optimization algorithm
Authors: Khan Muhammad Attique , Khan Awais , Alhaisoni Majed , Alqahtani Abdullah , Alsubai Shtwai , Alharbi Meshal , Malik Nazir Ahmed , Damaševičius Robertas 
Published: December 2022

AbstractIn the last decade, there has been a significant increase in medical cases involving brain tumors. Brain tumor is the tenth most common type of tumor, affecting millions of people. However, if it is detected early, the cure rate can increase. Computer vision researchers are working to develop sophisticated techniques for detecting and classifying brain tumors. MRI scans are primarily used for tumor analysis. We proposed an automated system for brain tumor detection and classification using a saliency map and deep learning feature optimization in this paper. The proposed framework was implemented in stages. In the initial phase of the proposed framework, a fusion‐based contrast enhancement technique is proposed. In the following phase, a tumor segmentation technique based on saliency maps is proposed, which is then mapped on original images based on active contour. Following that, a pre‐trained CNN model named EfficientNetB0 is fine‐tuned and trained in two ways: on enhanced images and on tumor localization images. Deep transfer learning is used to train both models, and features are extracted from the average pooling layer. The deep learning features are then fused using an improved fusion approach known as Entropy Serial Fusion. The best features are chosen in the final step using an improved dragonfly optimization algorithm. Finally, the best features are classified using an extreme learning machine (ELM). The experimental process is conducted on three publically available datasets and achieved an improved accuracy of 95.14, 94.89, and 95.94%, respectively. The comparison with several neural nets shows the improvement of proposed framework.
Bisphenol A exposure induces testicular oxidative damage via FTO/m6A/Nrf2 axis during postnatal development in mice
Authors: Ling Yuanchao , Huang Xiaodi , Li Anlong , Zhang Jinzhi , Chen Jianmei , Ren Jiale , Liu Yanan , Xie Meina 
Published: December 2022

AbstractBisphenol A (BPA), a commonly used plasticizer in the production of polycarbonate plastics and epoxy resins, has been shown to induce male reproductive toxicity. However, the effects of BPA exposure on early testicular development have not been thoroughly studied, and the underlying mechanism is yet to be elucidated. In the current study, neonatal male mice were exposed to BPA at 0, 0.1, and 5 mg/kg, respectively, by daily subcutaneous injection during postnatal day (PND) 1–35 to explore its effects on testicular development at PND 36 (the end of the first round of spermatogenesis). Morphological analyses showed that BPA exposure significantly induced apoptosis of testicular cells (p < 0.01 and p < 0.001) and reduced the thickness of seminiferous epithelium (p < 0.01). In addition, BPA exposure significantly decreased the total antioxidant capacity of testes and levels of transcription factor Nrf2 as well as its downstream antioxidant molecules of NQO1 and GPx‐1 (p < 0.05 and p < 0.01). Furthermore, global m6A modifications of mRNAs were upregulated accompanied by declined m6A demethylase (FTO) in the testes of BPA groups (p < 0.05 and p < 0.01). MeRIP‐quantitative real‐time polymerase chain reaction (qPCR) demonstrated that BPA exposure markedly increased the m6A modification of Nrf2 mRNA (p < 0.05 and p < 0.01). These findings suggest that upregulation of m6A induced by inhibited FTO may be involved in BPA‐induced testicular oxidative stress and developmental injury during postnatal development, which provides a new idea to reveal the mechanism underlying BPA interfering with testicular development.
Characterization of Immune Checkpoint Inhibitor–Induced Myasthenia Gravis Using the US Food and Drug Administration Adverse Event Reporting System
Authors: Niimura Takahiro , Zamami Yoshito , Miyata Koji , Mikami Takahisa , Asada Mizuho , Fukushima Keijo , Yoshino Masaki , Mitsuboshi Satoru , Okada Naoto , Hamano Hirofumi , Sakurada Takumi , Matsuoka‐Ando Rie , Aizawa Fuka , Yagi Kenta , Goda Mitsuhiro , Chuma Masayuki , Koyama Toshihiro , Izawa‐Ishizawa Yuki , Yanagawa Hiroaki , Fujino Hiromichi , Yamanishi Yoshihiro , Ishizawa Keisuke 
Published: December 2022

AbstractMyasthenia gravis (MG) is a rare but fatal adverse event of immune checkpoint inhibitors (ICIs). We assessed whether patient characteristics differed between those with ICI‐related myasthenia gravis and those with idiopathic myasthenia gravis. Reports from the US Food and Drug Administration Adverse Event Reporting System were analyzed. Multivariate analyses were conducted to evaluate the associations between age, sex, and ICI treatment and the reporting rate of myasthenia gravis. Among 5 464 099 cases between 2011 and 2019, 53 447 were treated with ICIs. Myasthenia gravis was reported more often in ICI users. Multiple logistic regression analyses showed that the reporting rate of ICI‐related myasthenia gravis did not differ significantly between men and women; however, it was higher in older people than in younger people (adjusted odds ratio, 2.4 [95%CI, 1.84–3.13]). We also investigated useful signs for the early detection of myositis and myocarditis, which are fatal when overlapping with ICI‐related myasthenia gravis. Patients with elevated serum creatine kinase or troponin levels were more likely to have concurrent myositis and myocarditis. Unlike idiopathic myasthenia gravis, there was no sex difference in the development of ICI‐related myasthenia gravis, which may be more common in older people. Considering the physiological muscle weakness that occurs in the elderly, it may be necessary to monitor ICI‐related myasthenia gravis more closely in older people.