bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tinjauan Kesan Pembiayaan Perbankan Islam kepada Sektor Pembinaan Infrastruktur Semasa Pandemik Di Indonesia
Authors: Mohamad Torik Langlang Buana  , Nuradli Ridzwan Shah Mohd Dali  , Intan Fatimah Anwar  
Published: January 2022

In early 2020, news in Indonesia announced through many media channels that a new virus, COVID-19, had been found and spread in Wuhan province, China. Later on, a patient was found in Indonesia, in Depok near Jakarta and rapidly spread throughout Jakarta. Preliminary action was taken by the governor of Jakarta, by implementing the Movement Control Order (MCO) in Jakarta starting in mid-March 2020 for students extended to the suspension of economic activities of almost all sectors in Indonesia. Subsequently, only fifteen sectors of business are allowed to operate which some of them is the banking and construction sectors. The Indonesian government continues to carry out recovery, including giving the first vaccine to the president in January 2021. The question is, how has this COVID-19 pandemic situation affected the financing of Islamic banks towards the construction sector ? This study use online data from available reports such as Indonesian Bank statistics and construction industrial reports to help the researchers in discussing for responding the research questions. The finding revealed that Islamic banks’ financing to construction sector is better at this pandemic period.
Abstrak
Pada awal 2020, berita di Indonesia telah mengumumkan melalui banyak saluran media bahawa sejenis virus baharu iaitu COVID-19 telah ditemui dan tersebar di daerah Wuhan, China. Walaubagaimanapun kemudian, seorang pesakit telah ditemui di Indonesia iaitu di Depok dan dengan pantas telah merebak ke seluruh Jakarta. Tindakan awal telah diambil oleh gabenor Jakarta, dengan melaksanakan Perintah Kendali Pergerakan (PKP) di Jakarta bermula pada pertengahan Mac 2020 bagi pelajar dan kemudian dilanjutkan kepada penangguhan aktiviti-aktiviti ekonomi hampir keseluruhan sektor di Indonesia. Namun begitu, hanya lima belas sektor yang dibenarkan beroperasi dan salah satunya adalah sektor bank dan pembinaan. Kerajaan Indonesia terus melakukan pemulihan termasuk pemberian vaksin pertama diberikan kepada presiden pada Januari 2021. Persoalannya adalah, bagaimanakah situasi pandemik COVID-19 ini telah mempengaruhi pembiayaan bank-bank Islam terhadap sektor pembinaan? Kajian ini menggunakan data dalam talian daripada laporan sedia ada seperti statistik bank Indonesia dan laporan pembinaan industri bagi membantu membuat keputusan kepada penyelidik dalam membincang persoalan kajian. Ditemukan pembiayaan daripada Bank Islam bagi sektor pembinaan lebih baik dari tahun sebelumnya.
قاعدة "تصرف الإمام في الرعية منوط بالمصلحة" وتطبيقها في نازلة كوفيد-19
Authors: Hanaffie Hasin  
Published: January 2022

Among the factors which play a great effect in causing the change in standard Islamic rulings is the occurance of a sudden widely spread catastrophe or pandemic which has resulted in large numbers of fatalities globally. In our current time, the Covid-19 has widely spread and adversely affected all aspects of daily life. In the time of pandemic or calamity, in general, the ruling government holds a great and heavy responsibilty in learning the Islamic ruling concerning the arising problems and thus taking the best decisions and measure in order to ease public affairs and put them in good order according to the Maqāṣid of Syarī‘ah (Objectives of Syarī ‘ah) in providing benefits for the citizens and safeguard them from harm. This goal is the core essence and ultimate purpose of governance in Islam. This study aims to elucidate the importance of the Legal Maxim: “Leader’s Actions Towards The People Are Based On Maṣlaḥah (Benefit)” in the light of collective ijtihād, knowledge and responsibilities according to Islamic rulings and Syarī‘ah governance to preserve the five kulliyyāt of Islamic Syarī‘ah (The Five General Objective of Syarī‘ah Islāmiyyah) in every aspect of both religious and worldly affairs. This study follows the descriptive and analytical methodologies in explaining the legal maxim from the view of Islamic Science tradition and, applied methodology in applying the legal maxim in dealing with the current Covid-19 pandemic and critical methodology in criticising some fatwa (legal ruling issued by Islamic scholars and authorities) in approaching and dealing with numerous issues related to this pandemic. Amongst the most important findings of this study is the important role of collective ijtihād which gather the government leaders, experts from every field, religious scholars and authorities to take any beneficial and unharmful decision based on the true methodology of Islamic teachings. This kind of ijtihād is extremely important to assure that every action done in facing this pandemic is in accordance with Allah’s law, therefore, in obtaining salvation in this worldly life and hereafter.
Frequency of Transition of patients with NYHA class III / IV to NYHA class I / II / III of stage C and D Heart Failure with Pharmacotherapy in a Tertiary Level Hospital
Authors: Ansari Sanjida , Kabir Md Faisal Ibn , Ahmed Khurshed , Ahsan Syed Ali , Ahmed Chaudhary Meskat , Khaled Md Fakhrul Islam , Siraj Mausool , Nahar Jannatun , Biswas Sumon Kumar , Karna Rajan , Ahsan Mohammad Hashimul , Islam Rashedul , Hoque Md Harisul 
Published: January 2022

Background: Heart failure (HF) is one of the most important health problems in terms of prevalence, morbidity, mortality and health service use. It affects around 2 to 3 % of the population. NYHA class can be used for the prioritization, triage and tailoring the HF management which is the foundation for the selection of therapies. The patient with higher NYHA class may need Mechanical Circulatory Support therapy or palliative care or hospice care. The identification of the patients with lower NYHA class helps to tailor vigorous drug therapy and close follow up program, the prognosis of these low risk patients maybe further improved. It is a simple tool for risk stratification in clinical practice.
Objective: The principal objective of this study was to determine frequency of transition of NYHA class III / IV to NYHA class I / II / III of stage C & D HF with drugs in a tertiary level hospital.
Methods: This was a crosssectional study. A total of 45 patients with stage C and D HF were enrolled in the study by consecutive sampling from October 2019 to September 2020. Detailed history including NYHA functional class of stage C and D HF, physical examination, relevant investigations and Echocardiography were done in all the subjects. The subjects were treated accordingly. The treatment response was assessed again with NYHA functional class on discharge.
Result: Patients had mean age of 62 &60 and 54 & 54 years for NYHA class III & IV of stage C and D HF. Majority of the patients were male. Primary cause of HF for both stage were IHD followed by DCM and valvular heart disease. The clinical presentation of stage C & D HF was improved significantly on discharge. Haematological, biochemical, radiological and echocardiographic findings of NYHA class IV of stage C & D HF was more worst.
Conclusion: There is statistically significant transition of NYHA class III of stage C and D HF to lower NYHA class but there is no statistically significant transition of NYHA class IV of stage C and D HF with pharmacotherapy in a tertiary level hospital. Higher NYHA class is associated with poor outcome of stage C & D HF patients.
University Heart Journal 2022; 18(1): 14-21
Six-month Outcome after Early Invasive Versus Delayed Ischaemia Driven Percutaneous Coronary Intervention in Non-ST Elevated Myocardial Infarction
Authors: Islam Rashedul , Ahsan Syed Ali , Rahman AKM Fazlur , Zaman SM mustafa , Khaled Md Fakhrul Islam , Biswas Suman Kumar , Ahasan Mohammad Hasimul , Ansari Sanjida , Karna Rajan , Ahmed Khurshed , Habib SM Ahsan , Rahman Md Mukhlesur 
Published: January 2022

Background: Optimal timing of PCI and comparative outcome between early invasive strategy and ischaemia guided delayed invasive strategy is still in debate in reducing long-term cardiovascular complications in NSTEMI.
Objective: The aim of the study was to assess the impact of an early invasive strategy or ischaemia guided delayed invasive strategy on six months clinical outcomes in NSTEMI patients undergoing PCI, from a Bangladesh health service perspective.
Materials and Method: It was an observational cross-sectional comparative study conducted in cardiology department of BSMMU from November 2019 to February 2021. Study procedure: This study enrolled 389 adult patients of NSTEMI who underwent PCI which met inclusion and exclusion criteria. Study subjects were divided into two groups: early and delayed groups. This study considered an early invasive strategy as - revascularization within 72h for patients presented with NSTEMI with high-risk features defined by a GRACE score > 140 and for those at lower risk with GRACE score <140; delayed ischaemia driven strategy as - revascularization after 72h, reserved for refractory, recurrent or severe exercise-induced ischaemia. Coronary angiogram (CAG) and PCI were performed by respective consultant according to current practice guidelines. After index PCI, patients were followed up at 06 months for MACEs (Myocardial re-infarction, target vessel revascularization, stroke, hospitalization due to ischaemic causes and cardiac death) and findings of 2 groups were compared.
Results: At 6 months after index PCI, patients in the early group despite having worse initial presentation and higher GRACE score had better outcome in comparison with the delayed group who had a statistically significant higher incidence of cardiac death, MI, and target vessel revascularization (p=0.002, p=0.004 and p=0.031). However, incidence of stroke, major bleeding and hospitalization due to ischemia were not significantly different between the groups (p>0.05).
Conclusion: Adoption of an early invasive strategy in NSTEMI patients undergoing PCI may be beneficial in reducing the risk of MACEs and associated with improved clinical outcome after PCI at 6 months follow-up.
University Heart Journal 2022; 18(1): 22-28
Prognostic Biomarker DDOST and Its Correlation With Immune Infiltrates in Hepatocellular Carcinoma
Authors: Zhu Changyu , Xiao Hua , Jiang Xiaolei , Tong Rongsheng , Guan Jianmei 
Published: January 2022

Background: Dolichyl-diphosphooligosaccharide–protein glycosyltransferase non-catalytic subunit (DDOST) is an important enzyme in the process of high-mannose oligosaccharide transferring in cells. Increasing DDOST expression is associated with impairing liver function and the increase of hepatic fibrosis degrees, hence exacerbating the liver injury. However, the relation between DDOST and hepatocellular carcinoma (HCC) has not been revealed yet.Method: In this study, we evaluated the prognostic value of DDOST in HCC based on data from The Cancer Genome Atlas (TCGA) database. The relationship between DDOST expression and clinical-pathologic features was evaluated by logistic regression, the Wilcoxon signed-rank test, and Kruskal–Wallis test. Prognosis-related factors of HCC including DDOST were evaluated by univariate and multivariate Cox regression and the Kaplan–Meier method. DDOST-related key pathways were identified by gene set enrichment analysis (GSEA). The correlations between DDOST and cancer immune infiltrates were investigated by the single-sample gene set enrichment analysis (ssGSEA) of TCGA data.Results: High DDOST expression was associated with poorer overall survival and disease-specific survival of HCC patients. GSEA suggested that DDOST is closely correlated with cell cycle and immune response via the PPAR signaling pathway. ssGSEA indicated that DDOST expression was positively correlated with the infiltrating levels of Th2 cells and negatively correlated with the infiltration levels of cytotoxic cells.Conclusion: All those findings indicated that DDOST was correlated with prognosis and immune infiltration in HCC.
The Resistance Mechanism Governs Physiological Adaptation of Escherichia coli to Growth With Sublethal Concentrations of Carbapenem
Authors: Schäfer Franca , Görner Pia , Woltemate Sabrina , Brandenberger Christina , Geffers Robert , Ziesing Stefan , Schlüter Dirk , Vital Marius 
Published: January 2022

Factors governing resistance in carbapenem-resistant Enterobacteriaceae are manifold. Despite ample research efforts, underlying molecular mechanisms are still only partly understood. Furthermore, little is known on (eco)physiological consequences from resistance acquisition originating from distinct mechanisms in respective bacteria.In this study, we examined physiological adaptation of Escherichia coli clinical isolates exhibiting two distinct resistance mechanisms–either carrying a carbapenemase (n = 4, CARB) or alterations in porin-encoding genes (n = 6, POR)–during growth with sublethal concentrations of ertapenem in chemostat culture. Basic growth parameters based on optical density and flow-cytometric analyses as well as global gene expression patterns using RNA-Seq were recorded. We demonstrate that strategies to deal with the antibiotic were distinct between strains of the two groups, where (increased) expression of carbapenemases was the major response in CARB, whereas wide-spread alterations in gene-expression that promoted a survival-like phenotype was observed in POR. The response in POR was accompanied with “costs of resistance” resulting in reduced growth efficiencies compared with CARB that are intrinsic to that group and were also observed during growth without antibiotic challenge, however, at lower levels. All strains showed similar minimal inhibitory concentrations and did not form phylogenetic groups, indicating that results cannot be attributed to distinct resistance levels or phylogenetic relationships, but are indeed based on the resistance mechanism.
Effects of Subcortical Atrophy and Alzheimer’s Pathology on Cognition in Elderly Type 2 Diabetes: The Alzheimer’s Disease Neuroimaging Initiative Study
Authors: Zhang Wen , Lu Jiaming , Qing Zhao , Zhang Xin , Zhao Hui , Bi Yan , Zhang Bing ,   the Alzheimer’s Disease Neuroimaging Initiative
Published: January 2022

BackgroundSubcortical atrophy and increased cerebral β-amyloid and tau deposition are linked to cognitive decline in type 2 diabetes. However, whether and how subcortical atrophy is related to Alzheimer’s pathology in diabetes remains unclear. This study therefore aimed to investigate subcortical structural alterations induced by diabetes and the relationship between subcortical alteration, Alzheimer’s pathology and cognition.MethodsParticipants were 150 patients with type 2 diabetes and 598 propensity score-matched controls without diabetes from the Alzheimer’s Disease Neuroimaging Initiative. All subjects underwent cognitive assessments, magnetic resonance imaging (MRI), and apolipoprotein E (ApoE) genotyping, with a subset that underwent amyloid positron emission tomography (PET) and cerebrospinal fluid (CSF) assays to determine cerebral β-amyloid deposition (n = 337) and CSF p-tau (n = 433). Subcortical structures were clustered into five modules based on Pearson’s correlation coefficients of volumes across all subjects: the ventricular system, the corpus callosum, the limbic system, the diencephalon, and the striatum. Using structural equation modeling (SEM), we investigated the relationships among type 2 diabetes, subcortical structural alterations, and AD pathology.ResultsCompared with the controls, the diabetic patients had significant reductions in the diencephalon and limbic system volumes; moreover, patients with longer disease duration (&gt;6 years) had more severe volume deficit in the diencephalon. SEM suggested that type 2 diabetes, age, and the ApoE ε4 allele (ApoE-ε4) can affect cognition via reduced subcortical structure volumes (total effect: age &gt; ApoE-ε4 &gt; type 2 diabetes). Among them, age and ApoE-ε4 strongly contributed to AD pathology, while type 2 diabetes neither directly nor indirectly affected AD biomarkers.ConclusionOur study suggested the subcortical atrophy mediated the association of type 2 diabetes and cognitive decline. Although both type 2 diabetes and AD are correlated with subcortical neurodegeneration, type 2 diabetes have no direct or indirect effect on the cerebral amyloid deposition and CSF p-tau.
The Use of Neuroimaging for Predicting Sumatriptan Treatment Response in Patients With Migraine
Authors: Wu Jr-Wei , Lai Pi-Yi , Chen Yung-Lin , Wang Yen-Feng , Lirng Jiing-Feng , Chen Shu-Ting , Lai Kuan-Lin , Chen Wei-Ta , Wu Yu-Te , Wang Shuu-Jiun 
Published: January 2022

ObjectivesTo identify the neuroimaging predictors for the responsiveness of patients to sumatriptan and use an independent cohort for external validation.MethodsStructuralized headache questionnaire and 3-Tesla brain magnetic resonance imaging were performed in migraine patients. Regional brain volumes were automatically calculated using FreeSurfer version 6.0, including bilateral amygdala, anterior cingulated cortex, caudate, putamen, precuneus, orbitofrontal cortex, superior frontal gyri, middle frontal gyri, hippocampus, and parahippocampus. A sumatriptan-responder was defined as headache relief within 2 h after the intake of sumatriptan in at least two out of three treated attacks. We constructed a prediction model for sumatriptan response using the regional brain volume and validated it with an independent cohort of migraine patients.ResultsA total of 105 migraine patients were recruited, including 73 sumatriptan responders (69.5%) and 32 (30.5%) non-responders. We divided the migraine patients into derivation (n = 73) and validation cohorts (n = 32). In the derivation cohort, left hippocampal volume was larger in sumatriptan responders (responders vs. non-responders: 3,929.5 ± 403.1 vs. 3,611.0 ± 389.9 mm3, p = 0.002), and patients with a larger left hippocampal volume had a higher response rate to sumatriptan (&gt;4,036.2 vs. ≤4,036.2 mm3: 92.0 vs. 56.3%, p = 0.001). Based on the findings, we constructed a prediction model using the cutoff value of 4,036.2 mm3, and we found that patients with a left hippocampal volume &gt;4,032.6 mm3 had a higher response rate to sumatriptan than those with a left hippocampal volume ≤4,032.6 mm3 (84.6 vs. 42.1%, odds ratio [OR] = 7.6 [95% confidence interval = 1.3–44.0], p = 0.013) in the validation cohort.ConclusionOur study showed that left hippocampal volume is helpful to identify sumatriptan non-responders. This proof-of-concept study shows that left hippocampal volume could be used to predict the treatment response to sumatriptan in migraine patients.
Effect of Cognition Recovery by Repetitive Transcranial Magnetic Stimulation on Ipsilesional Dorsolateral Prefrontal Cortex in Subacute Stroke Patients
Authors: Kim Jongwook , Cha Byoungwoo , Lee Doyoung , Kim Jong Moon , Kim MinYoung 
Published: January 2022

ObjectiveTo demonstrate the efficacy of high-frequency repetitive transcranial magnetic stimulation (rTMS) over the ipsilesional dorsolateral prefrontal cortex (DLPFC) on neurological recovery in patients with subacute phase stroke.MethodsPatients with supratentorial hemispheric stroke who were hospitalized for intensive rehabilitation in the subacute phase were enrolled for this retrospective analysis. Two groups of patients were selected: the rTMS group who received high-frequency (20 Hz) rTMS ≥ 5 times over the ipsilesional DLPFC, and a control group who did not receive any rTMS. The patients were further divided into groups with right- or left-side brain lesions. Functional measurements for cognitive ability, mood, speech, and activities of daily living, which were assessed at baseline and at the 1-month follow-up as a routine clinical practice, were used for analyses.ResultsAmong 270 patients with available clinical data, 133 (women, 51; age, 61.0 ± 13.8 years) met the inclusion criteria and were enrolled for analysis. There were no differences in demographic data and functional scores at baseline between the rTMS (n = 49) and control (n = 84) groups. The rTMS group showed a higher gain in the mini-mental status examination (MMSE) total score and subscores of all domains, forward digit span, and FIM-cognition than the control group (P &lt; 0.05). Among the patients with left hemispheric lesions (n = 57), the rTMS group showed better outcomes in cognition and depression through scores of total and “attention and concentration” subscores of MMSE, FIM-cognition, and the geriatric depression scale (P &lt; 0.05). Among the patients with right hemispheric lesions (n = 76), the rTMS group showed better outcomes in cognition through the MMSE total score and subscores of “attention and concentration,” “registration,” and “recall,” and scores of both forward and backward digit spans (P &lt; 0.05).ConclusionHigh-frequency rTMS over the ipsilesional DLPFC has beneficial effects on the recovery of cognition on both sides as well as mood in patients with left-sided hemispheric lesions.
MECOM/PRDM3 and PRDM16 Serve as Prognostic-Related Biomarkers and Are Correlated With Immune Cell Infiltration in Lung Adenocarcinoma
Authors: Li Meng , Ren Hui , Zhang Yanpeng , Liu Na , Fan Meng , Wang Ke , Yang Tian , Chen Mingwei , Shi Puyu 
Published: January 2022

BackgroundThe MDS1 and EVI1 complex locus (MECOM, also called PRDM3) and PR domain containing 16 (PRDM16) are two highly related zinc finger transcription factors associated with many malignancies. However, the mechanisms of MECOM and PRDM16 in prognosis and tumor immune infiltration in lung adenocarcinoma (LUAD) remain uncertain.MethodsThe Cancer Genome Atlas (TCGA), Oncomine, UALCAN, GEPIA, and TIMER databases were searched to determine the relationship between the expression of MECOM and PRDM16, clinicopathological features, immune infiltration, and prognosis in LUAD. Coexpressed genes of the two genes were investigated by CBioPortal, and the potential mechanism of MECOM- and PRDM16-related genes was elucidated by GO and KEGG analyses. STRING database was utilized to further construct the protein-protein interaction network of the coexpressed genes, and the hub genes were identified by Cytoscape. Finally, qRT-PCR was performed to identify the mRNA levels of the target genes in LUAD.ResultsmRNA levels of MECOM and PRDM16 were downregulated in LUAD (p &lt; 0.05), and the low expression of the two genes was associated with the age, gender, smoking duration, tissue subtype, poor stage, nodal metastasis status, TP53 mutation, and prognosis in LUAD (p &lt; 0.05). MECOM and PRDM16 were also found to be correlated with the expression of a variety of immune cell subsets and their markers. KEGG analysis showed that both of them were mainly enriched in the cell cycle, cellular senescence, DNA replication, and p53 signaling pathway. Importantly, the mRNA levels of the two genes were also found to be decreased in the clinical samples of LUAD by qRT-PCR.ConclusionMECOM and PRDM16 may serve as potential prognostic biomarkers which govern immune cell recruitment to LUAD.