bluuebunny/crossref_metadata_2025_split huggingface dataset:
Robust and Heterogenous Odds Ratio: Estimating Price Sensitivity for Unbought Items
Authors: Pauphilet Jean 
Published: June 2022

Problem definition: Mining for heterogeneous responses to an intervention is a crucial step for data-driven operations, for instance, to personalize treatment or pricing. We investigate how to estimate price sensitivity from transaction-level data. In causal inference terms, we estimate heterogeneous treatment effects when (a) the response to treatment (here, whether a customer buys a product) is binary, and (b) treatment assignments are partially observed (here, full information is only available for purchased items). Methodology/Results: We propose a recursive partitioning procedure to estimate heterogeneous odds ratio, a widely used measure of treatment effect in medicine and social sciences. We integrate an adversarial imputation step to allow for robust estimation even in presence of partially observed treatment assignments. We validate our methodology on synthetic data and apply it to three case studies from political science, medicine, and revenue management. Managerial implications: Our robust heterogeneous odds ratio estimation method is a simple and intuitive tool to quantify heterogeneity in patients or customers and personalize interventions, while lifting a central limitation in many revenue management data.History: This paper has been accepted as part of the 2020 MSOM Data Driven Research Challenge.Supplemental Material: The online appendix is available at https://doi.org/10.1287/msom.2022.1118 .
Early field growth performance of ten selected bamboo taxa: The case study of Sabal bamboo pilot project in Sarawak, Malaysia
Authors: HASSAN NURUL HUSNA MOHD , ABDULLAH NIZAM , KELANA DAYANG NORZIEYANA AWANG , PERUMAL MUGUNTHAN 
Published: June 2022

Abstract. Hassan NHM, Abdullah N, Kelana DNA, Perumal M. 2022. Early field growth performance of ten selected bamboo taxa: The case study of Sabal bamboo pilot project in Sarawak, Malaysia. Biodiversitas 23: 2882-2892. Information on early growth performance and survival rate of bamboos are pivotal for the development of the Sarawak bamboo industry. Thus, a study on the early growth performance of ten bamboo taxa was conducted at the Sarawak Bamboo Pilot Project site in Sabal, Simunjan, Sarawak, Malaysia. Six taxa were originated from Yogyakarta, Indonesia, and the other four bamboo taxa were originated locally from Sarawak. Study sites were established at bamboo plantation areas at different age stands. Two replications of data for each taxon involving 50 readings (25 readings for one replication) were measured and quantified for growth parameters of the number of culms per clump, number of new shoots, culm diameter, and culm height. The findings indicated that Gigantochloa hasskarliana (Busi bamboo) had the highest number of culms per clump (43) while Guadua angustifolia (Duri bamboo) had the highest number of new bamboo shoots (2.93). Nonetheless, Dendrocalamus asper (Green) had the highest culm diameter (3.61 cm) while Bambusa balcooa (Bema bamboo) had the highest culm height (8.36 m). The results showed that different bamboo species have different early growth performances, thus further detailed investigation and long-term monitoring period are required to achieve the commercial plantation scale, especially in Sarawak.
Wildlife-vehicle collisions in Khao Yai National Park, Thailand: Impact on native species for some conservation management
Authors: Rattanawanawong Nattaphat , Bhumpakphan Naris , Kutintar Utis , Sukmasuang Ronglarp 
Published: June 2022

Abstract. Rattanawanawong N, Bhumpakphan N, Kutintara U, Sukmasuang R. 2022. Wildlife-vehicle collisions in Khao Yai National Park, Thailand: Impact on native species for some conservation management. Biodiversitas 23: 3050-3061. Wildlife-vehicle collisions (WVCs) remain a major challenge in wildlife management worldwide, especially in conservation areas with transport routes passing through. This study was operated along a 48 km long highway, which conducted 207 surveys in a natural world heritage site from February 2018 to January 2019. A total of 391 wild animal carcasses were found in 90 species. The carcasses found, according to the taxonomic group, were reptiles (67.52%), followed by mammals (14.83%), amphibians (4.35%), birds (3.32%). Reptiles were most affected by road use, especially tortoises in Family Geoemydidae and Family Testudinidae that two critically endangered species were found. This study found that members of Family Colubridae were most affected that 26 species, a total of 144 animal carcasses were found, accounting for 29.15% of the number of all carcasses. The most affected species were forest garden lizard (Calotes emma) in the Family Agamidae, where 99 carcasses were found, accounting for 25.31% of the total. In March showed the highest number of the carcasses, followed by April. All of the carcasses found in the evening slightly more than the morning indicated that wild animals died more during the day than at night. The number of vehicles day-1 significantly affected wildlife mortality per day. Reducing the number of vehicles per day-1 entering and reducing vehicle speed, including the number of tourists, as well as banning travel at night, would mitigate the problem. Further, educational signage about wildlife diversity and the risk of road mortality should be installed at the park to remind visitors about the unique fauna in the national park and emphasize the importance of conservation.
Short Communication: Agronomical characteristics of sweet corn under different plant growth regulators during the dry season
Authors: MUBAROK SYARIFUL , WICAKSONO FIKY YULIANTO , NURAINI ANNE , RAHMAT BAYU PRADANA NUR , BUDIARTO RAHMAT 
Published: June 2022

Abstract. Mubarok S, Wicaksono FY, Nuraini A, Rahmat BPN, Budiarto R. 2022.S hort Communication: Agronomical characteristics of sweet corn under different plant growth regulators during the dry season. Biodiversitas 23: 3091-3098. Sweet corn (Zea mays convar. saccharata var. rugosa)is one of the important horticultural crops. Increasing sweet corn production during the dry season can be achieved by applying plant growth regulators (PGR). PGRs such as auxin, gibberellin, cytokinin, ethylene, and other phytohormones control various physiological and chemical processes in plants. The PGR is often used for the engineering process of plant cultivation technology, especially during environmental stress conditions. This study aimed to determine the effect of PGRs (auxin, gibberellic acid, salicylic acid, and paclobutrazol) on sweet corn growth and yield during the dry season. The results showed that the application of PGR significantly affected sweet corn growth, yield, and yield quality during the dry season. The auxin significantly increased plant height and leaf length, whereas paclobutrazol and salicylic acid significantly increased the number of cobs and total soluble solids of sweet corn, respectively.
Effects of electroacupuncture on the expression of hypothalamic neuropeptide Y and ghrelin in pubertal rats with polycystic ovary syndrome
Authors: Li Yang , Zhi Wang , Haoxu Dong , Qing Wang , Ling Cheng , Ping Yi , Dongmei Huang 
Published: June 2022

Background
Polycystic ovary syndrome often starts in puberty, and its pathogenesis is not clear. This study aimed to explore the pathogenesis of pubertal polycystic ovary syndrome (PCOS) and assess the therapeutic effect of electroacupuncture on pubertal PCOS.

Methods
Dihydrotestosterone (DHT) was used to induce rat models of pubertal PCOS. pubertal rats with PCOS were randomly divided into a model group (M), an electroacupuncture group (EA), and a sham acupuncture group (SA). Age-matched normal rats were regarded as normal controls (N). Rats were treated with EA or SA five times a week for 25 minutes during their 6th–7th week. At the end of the experiment, we observed any changes in ovarian morphology; detected levels of metabolic indices in serum, the hypothalamus and pancreas.

Results
EA significantly improved estrous cycle disorders and the ovarian polycystic morphology in pubertal rats with PCOS, but SA only improved disorders of the estrous cycle. The serum levels of insulin, neuropeptide Y(NPY) and fasting blood glucose(FBG) increased significantly (both p < 0.01), while the serum levels of ghrelin(GHRL) decreased in the model group (p < 0.01). After treatment with EA, the levels of NPY (p < 0.01) and FBG (p < 0.05) went into decrease, whereas the levels of GHRL (p < 0.05) and insulin (p < 0.01) increased. There was few differences in the hypothalamic expression of galanin (GAL), galanin-like peptide (GALP) and ghrelin receptor(GHSR) between the four groups. The upregulation of NPY mRNA and neuropeptide Y2 receptor(NPY2R) mRNA and the downregulation of GHRL protein and mRNA in the hypothalamus, and the increased expression of NPY and NPY2R as well as the decreased expression of GHRL in the arcuate nucleus (ARC) can be rescued by EA. But, surprisingly, SA seem to make no difference to the levels of FBG and insulin, and the protein expression of ghrelin in the hypothalamus and ARC. Co-expression of kisspeptin and GHSR, and co-expression of gonadotrophin releasing hormone(GnRH) and NPY2R were observed in ARC. No differences were found between groups in protein of GAL, GALP and GHRL expression in the pancreas. Neither EA nor SA can attenuate the upregulated kisspeptin protein expression in the pancreas of PCOS model rats.

Conclusions
EA and SA improved the symptoms of pubertal PCOS rats, and the mechanism might be associated with regulating hypothalamic NPY and ghrelin levels.
The Tanah-Air Concept and Indonesia’s Maritime Nation Aspiration
Authors: Alverdian Indra 
Published: June 2022

This article analyses the Tanah-Air (Unity of Land-Water) concept conceived by Indonesian founding fathers during its independence period and its centrality in shaping the nation’s maritime outlook. Specifically, using descriptive historical analytical approach, it would like to emphasize the role of intersection of Indonesia’s political culture of national unity (Persatuan Nasional), strategic culture of turning of the ages of Nusantara (Cakra Manggilingan), and geopolitical outlook of archipelago’s heart seas (Segara Nusantara) as the three forming pillars of the Tanah-Air concept. Based on these intersections, it underlines unique contradictions within the Tanah-Air concept between need for unity and oneness of land-sea elements of the Indonesian archipelago and the concentric Javanese philosophy on the sea and its maritime power aspirations. Based on these contradictions and insight of the ‘Tanah-Air’ concept, the article provides a pragmatic view on Indonesia’s current aspiration of moving beyond archipelagic to maritime nation as stipulated in the 2014 Global Maritime Fulcrum Doctrine and 2017 Sea Policy Whitepaper.
Cristaluria por sulfadiazina en paciente con nefropatía lúpica
Authors: Ruiz Álvarez María J. , Molina-Blas Sergio , Barrionuevo-González Marta , Peñas-Lorite María E. , Gasalla-Herraiz José M. 
Published: June 2022

Resumen

Objetivos
Se estima que el 29% de los pacientes tratados con sulfadiazina pueden desarrollar un fallo renal agudo. Para su diagnóstico debemos recurrir a un análisis del sedimento urinario.

Caso clínico
Paciente de 71 años que consulta por pérdida de agudeza visual en el contexto de un brote de Lupus eritematoso sistémico (LES). Se diagnosticó de necrosis retiniana aguda, pendiente de filiación etiológica. Se inició empíricamente tratamiento con sulfadiazina. En los estudios analíticos de seguimiento se solicita sedimento urinario, en el cual se objetivan los siguientes hallazgos: pH 6, 30–50 hematíes/campo, células epiteliales de vías bajas y de transición, cilindros hialinos, gotas de grasa o cuerpos de cruz de Malta y abundantes cristales de sulfadiazina. Se comunica este hallazgo al Servicio de Nefrología y se suspende el tratamiento de forma inmediata.

Conclusiones
La sulfadiazina es un antibiótico de la familia de las sulfamidas. Su cristalización en el interior de los túbulos renales puede causar nefritis instersticial aguda. Estos cristales adoptan una morfología muy diversa en función del metabolito que cristalice: las formas inalteradas precipitan en forma de cristales densos y globulares, o como en el caso de nuestro paciente, los cristales adoptan forma de espigas de trigo en abanico.
Medición del contenido de aluminio en especímenes biológicos: aplicación en el laboratorio clínico
Authors: Pérez San Martín Sonia , Bauçà Josep Miquel , Martínez-Morillo Eduardo 
Published: June 2022

Resumen
El aluminio se incorpora en el organismo principalmente por la dieta o la exposición ocupacional y se excreta por vía renal. Puede retenerse y presentar toxicidad especialmente en individuos con insuficiencia renal, incluso en aquellos que están sometidos a procesos de diálisis. Sus mecanismos de toxicidad están relacionados con el aumento del estrés oxidativo e inflamatorio, dishomeostasis del hierro y el calcio o la desregulación colinérgica, entre otros. En este documento se revisan los especímenes y métodos analíticos para la medida de aluminio en especímenes biológicos y agua de diálisis. Se detallan aquellos aspectos más relevantes para asegurar su calidad. Pretende ser una guía práctica para el desarrollo e implementación de un procedimiento de medida fiable del aluminio en un laboratorio clínico.
El aluminio en suero es el principal biomarcador para el estudio de su toxicidad, mientras que para la evaluación de una exposición crónica se recomienda la orina. Actualmente, la tecnología de espectrometría de masas de plasma acoplado inductivamente (ICP-MS) es la recomendada por presentar mejores límites de cuantificación, selectividad y robustez.
Se ofrecen recomendaciones claras sobre los especímenes utilizados en la medición de aluminio y las principales consideraciones preanalíticas, analíticas y postanalíticas.
Homocysteine in coronavirus disease (COVID-19): a systematic literature review
Authors: Carpenè Giovanni , Negrini Davide , Henry Brandon M. , Montagnana Martina , Lippi Giuseppe 
Published: June 2022

Abstract

Objectives
Coronavirus disease 2019 (COVID-19) is a life-threatening infectious disorder characterized by a sustained prothrombotic state. Since homocysteine is a potential biomarker of thrombotic diseases, the aim of this article is to provide an updated overview on the possible role played by hyperhomocysteinemia in influencing an unfavorable COVID-19 progression.

Methods
We carried out an electronic search in Medline (PubMed interface) using the keywords (“COVID-19” OR “SARS-CoV-2”) AND “homocysteine”, between 2019 and the present time, with no language restrictions, to identify all articles which explored the concentration of homocysteine in COVID-19 patients with or without unfavorable disease progression.

Results
Three studies, totaling 694 hospitalized COVID-19 patients, were included in our systematic review. Overall, the differences between the mean homocysteine values in non-severe vs. severe COVID-19 patients were always positive (i.e., 15.1%, 24.1% and 22.8%, generating a positive weight mean difference of 1.75 μmol/L (95%CI, 1.26–2.25 μmol/L; p=0.011), which translates into a cumulative difference of approximately ∼1.2 μmol/L.

Conclusions
Despite the limited evidence that has been garnered so far, increased homocysteine ​​levels may be a potentially useful marker for predicting the risk of unfavorable progression in patients with COVID-19.
Multisite assessment of emergency medicine resident knowledge of evidence-based medicine as measured by the Fresno Test of Evidence-Based Medicine
Authors: Katsilometes James , Galuska Michael , Kraus Chadd K. , Levitin Howard W. , Leuchten Scott , Daugherty-Luck Jane , Lata Julie , Brannan Grace , Santarelli Anthony , Ashurst John 
Published: June 2022

Abstract

Context
Evidence-based medicine (EBM) is the application of scientific evidence while treating a patient. To date, however, there is very little evidence describing how residents in emergency medicine understand and incorporate EBM into practice.

Objectives
The aim of this study was to determine EBM theoretical and quantitative knowledge in emergency medicine residents in community hospital-based training programs.

Methods
A sample of emergency medicine residents from nine hospitals was enrolled to complete a cross-sectional assessment of EBM skills from April 2021 through June 2021. Performance on the Fresno Test of Evidence-Based Medicine (FTEBM) was assessed utilizing descriptive statistics, t tests, and one-way analysis of variance.

Results
A total of 50.8% (124/244) of current emergency medicine residents completed the FTEBM during the study period. No significant difference on FTEBM scores was noted between the different types of medical degrees (DO vs. MD) (p=0.511), holding an advanced research degree (p=0.117), or between each postgraduate year of training (p=0.356). The mean score of those residents who rated their knowledge of EBM as average or higher was 36.0% (32.8–39.1%). The mean score of those residents who rated their programs as having an “average” or higher institutional focus on EBM was 34.9% (32.2–37.6%).

Conclusions
Participating emergency medicine residents show an incomplete understanding of EBM both in theory and applied computations despite rating themselves as having an average understanding. Emergency medicine residencies would be well suited to implement a standardized EBM curriculum that focuses on longitudinal reinforcement of key concepts needed for the practicing physician.
Comparison of insulin sensitivity indices for detection of double diabetes in Indian adolescents with type 1 diabetes
Authors: Oza Chirantap , Khadilkar Anuradha , Karguppikar Madhura , Gondhalekar Ketan , Khadilkar Vaman 
Published: June 2022

Abstract

Objectives
The role of insulin sensitivity (IS) in the development and progression of metabolic syndrome (MS) in subjects with type-1 diabetes (T1D) is being increasingly recognized. As patients with T1D lack endogenous insulin secretion, measurement of insulin concentration by immunoassay or by indices such as homeostasis model of assessment for insulin resistance (HOMA-IR) is not helpful in assessing IS. Hence, some equations have been developed and validated against data from euglycemic-hyper-insulinemic clamp tests (the gold standard) to estimate IS. 1) To assess IS using available equations (EDC, SEARCH and CACTI) and relationship of IS with MS and microalbuminuria in adolescents with T1D, (2) To compare the predictive value of these equations for detection of MS and derive a cut-off to predict the future risk of development of MS and microalbuminuria and (3) To identify the most accurate non-invasive and easy-to-use equation for detecting patients with double diabetes (DD) in a clinical setting.

Methods
This cross-sectional study included 181 adolescents aged 12–18 years with T1D. Demographic data and laboratory measurements were performed using standard protocols. IS was calculated using following equations:(1) EDC=24.31−12.22×(WHR)−3.29×(hypertension)−0.57×(HbA1c), (2) SEARCH=exp(4.64725−0.02032(waist)−0.09779(HbA1c)−0.00235(Triglycerides), (3)CACTI-exA=exp(4.1075–0.01299×(waist)−1.05819×(insulin dose)−0.00354×(Triglycerides)−0.00802×(DBP)).

Results
IS determined by all three methods had significant negative correlation (p<0.05) with MS as well as with microalbuminuria. The cut-off value of 5.485 mg/kg/min by SEARCH method for determining IS had the highest sensitivity and specificity in identifying MS.

Conclusions
IS by SEARCH equation may be used in routine clinical practice to detect DD in Indian adolescents with T1D at risk of developing metabolic as well as microvascular complications.
ALKBH5 inhibits TNF-α-induced apoptosis of HUVECs through Bcl-2 pathway
Authors: Zhang Xiaoshan , Deng ShiBing , Peng Yang , Wei Han , Tian Zhiming 
Published: June 2022

Abstract
The dysfunction and apoptosis of vascular endothelial cells are the initiating links in the formation of atherosclerosis. N6-methyladenosine (m6A) is an extremely extensive RNA methylation modification and its abnormality leads to the occurrence of various human diseases. In this study, we explored the effects of demethylase α-ketoglutarate-dependent dioxygenase ALKB homolog 5 (ALKBH5) on TNF-α-induced apoptosis of human umbilical vein endothelial cells (HUVECs). In TNF-α-treated HUVECs, the expression of ALKBH5 was significantly decreased. ALKBH5 overexpression promoted the proliferation and inhibited the apoptosis in TNF-α-treated HUVECs, suggesting that ALKBH5 had a protective effect on cell damage induced by TNF-α. Importantly, ALKBH5 promoted the expression of Bcl-2 in HUVECs. Bcl2 overexpression reduced the expression of Gadd45, Bax, and p21, which are transcriptionally activated by p53. But the expression of p53 has not been significantly affected, indicating that Bcl2 might regulate the apoptosis by inhibiting p53 downstream targets. In addition, ALKBH5 overexpression significantly increased the level of pri-miR-7 and decreased the level of miR-7. In conclusion, ALKBH5 attenuated the TNF-α-induced cell injury via promoting Bcl2 expression. Our research expands the understanding of the progression mechanism of atherosclerosis and provides a potential strategy for the protection of vascular endothelial injury.
Jacob Burckhardt und die französische Interpretation der »Renaissance«: Wandlungen des Begriffs von den frühen Tessin-Studien bis zum Cicerone
Authors: Karge Henrik 
Published: June 2022

Abstract
The popularisation of the term “Renaissance” in the German-speaking world owes much to Jacob Burckhardt. Until 1840, however, the use of this period term still reflected its French origins. Burckhardt himself, as a scholar still in his twenties, applied it (albeit with some reservations about the etymology) primarily to sixteenth-century architecture and ornamentation in France and in neighbouring regions. Only a decade later did he redefine the term and associate it enthusiastically with Italian art and architecture. Burckhardt’s early use of the word “Renaissance” conveys much of the fascination that the simultaneously hybrid and opulent French art of the decades around 1500 held in nineteenth-century Europe.
The effects of variable viscosity on magnetic field intensity with heat, mass transfer over a vertical plate
Authors: Abubakar Hamza , Isah Sani , Uwanta I. J. 
Published: June 2022

This paper examines the effects of variable viscosity with heat and mass transfer over a vertical layer on the magnetic field intensity. The governing equation of continuity, energy, momentum, and concentration is transformed into the ordinary differential equations and then solved through the technique of perturbation. Expressions were generated for distribution of velocity, temperature, and concentration. Tests for parameter values of importance are described graphically and addressed quantitatively from a practical point of view.