bluuebunny/crossref_metadata_2025_split huggingface dataset:
Self- and Partner-Reported Subjective Memory Complaints: Association with Objective Cognitive Impairment and Risk of Decline
Authors: Zuroff Leah , Wisse Laura EM , Glenn Trevor , Xie Sharon X. , Nasrallah Ilya M. , Habes Mohamad , Dubroff Jacob , de Flores Robin , Xie Long , Yushkevich Paul , Doshi Jimit , Davatsikos Christos , Shaw Leslie M. , Tropea Thomas F. , Chen-Plotkin Alice S. , Wolk David A , Das Sandhitsu , Mechanic-Hamilton Dawn 
Published: July 2022

Background: Episodic memory decline is a hallmark of Alzheimer’s disease (AD). Subjective memory complaints (SMCs) may represent one of the earliest signs of impending cognitive decline. The degree to which self- or partner-reported SMCs predict cognitive change remains unclear. Objective: We aimed to evaluate the relationship between self- and partner-reported SMCs, objective cognitive performance, AD biomarkers, and risk of future decline in a well-characterized longitudinal memory center cohort. We also evaluated whether study partner characteristics influence reports of SMCs. Methods: 758 participants and 690 study partners were recruited from the Penn Alzheimer’s Disease Research Center Clinical Core. Participants included those with Normal Cognition, Mild Cognitive Impairment, and AD. SMCs were measured using the Prospective and Retrospective Memory Questionnaire (PRMQ), and were evaluated for their association with cognition, genetic, plasma, and neuroimaging biomarkers of AD, cognitive and functional decline, and diagnostic progression over an average of four years. Results: We found that partner-reported SMCs were more consistent with cognitive test performance and increasing symptom severity than self-reported SMCs. Partner-reported SMCs showed stronger correlations with AD-associated brain atrophy, plasma biomarkers of neurodegeneration, and longitudinal cognitive and functional decline. A 10-point increase on baseline PRMQ increased the annual risk of diagnostic progression by approximately 70%. Study partner demographics and relationship to participants influenced reports of SMCs in AD participants only. Conclusion: Partner-reported SMCs, using the PRMQ, have a stronger relationship with the neuroanatomic and cognitive changes associated with AD than patient-reported SMCs. Further work is needed to evaluate whether SMCs could be used to screen for future decline.
Does Loss of Integrity of the Cingulum Bundle Link Amyloid-β Accumulation and Neurodegeneration in Alzheimer’s Disease?
Authors: Vlegels Naomi , Ossenkoppele Rik , van der Flier Wiesje M. , Koek Huiberdina L. , Reijmer Yael D. , Wisse Laura EM , Biessels Geert Jan ,   the Alzheimer’s Disease Neuroimaging Initiative
Published: July 2022

Background: Alzheimer’s disease is characterized by the accumulation of amyloid-β (Aβ) into plaques, aggregation of tau into neurofibrillary tangles, and neurodegenerative processes including atrophy. However, there is a poorly understood spatial discordance between initial Aβ deposition and local neurodegeneration. Objective: Here, we test the hypothesis that the cingulum bundle links Aβ deposition in the cingulate cortex to medial temporal lobe (MTL) atrophy. Methods: 21 participants with mild cognitive impairment (MCI) from the UMC Utrecht memory clinic (UMCU, discovery sample) and 37 participants with MCI from Alzheimer’s Disease Neuroimaging Initiative (ADNI, replication sample) with available Aβ-PET scan, T1-weighted and diffusion-weighted MRI were included. Aβ load of the cingulate cortex was measured by the standardized uptake value ratio (SUVR), white matter integrity of the cingulum bundle was assessed by mean diffusivity and atrophy of the MTL by normalized MTL volume. Relationships were tested with linear mixed models, to accommodate multiple measures for each participant. Results: We found at most a weak association between cingulate Aβ and MTL volume (added R2 <0.06), primarily for the posterior hippocampus. In neither sample, white matter integrity of the cingulum bundle was associated with cingulate Aβ or MTL volume (added R2 <0.01). Various sensitivity analyses (Aβ-positive individuals only, posterior cingulate SUVR, MTL sub region volume) provided similar results. Conclusion: These findings, consistent in two independent cohorts, do not support our hypothesis that loss of white matter integrity of the cingulum is a connecting factor between cingulate gyrus Aβ deposition and MTL atrophy.
Assessment Tools to Evaluate Motor Function in People with Dementia: A Systematic Review
Authors: Leitão Mariana , Saúde Alexandra , Bouça-Machado Raquel , Ferreira Joaquim J. 
Published: July 2022

Background: In addition to cognitive changes, motor impairments have been observed in patients with dementia and are present early in the disease, even at the preclinical stage. Although it is difficult to assess motor function in this population, it is critical for monitoring disease progression and determining the efficacy of therapeutic interventions. However, the best measurement tools for assessing motor function in dementia patients have yet to be determined. Objective: We aimed to summarize and critically evaluate the measurement tools used to assess motor function indementia. Methods: A systematic review was conducted using the databases CENTRAL, MEDLINE, Embase, and PEDro from their inception to June 2021 to identify all experimental studies conducted in patients with dementia and that included an assessment of motor function. Two reviewers independently screened citations, extracted data, and assessed clinimetric properties. Results: We included 200 studies that assess motor function in dementia patients. Motor function was assessed using a total of 84 different measurement tools. Only nine (12%) were used in over ten studies. The Timed-Up-and-Go test, 6MWT, Berg Balance Scale, and the Short Physical Performance Battery are all suggested. Conclusion: Currently, a wide variety of measurement instruments are used to assess motor performance in people with dementia, most instruments were not designed for this population and have not been validated for this use. We propose the development of an assessment protocol tailored to the different disease stages. We also recommend that future research continues to develop technological devices that can assist with this task.
Antioxidants and their role in the prevention and treatment of chronic kidney disease (CKD), perspective of complementary nursing and medicine: a review
Authors: Dehkordi Ali Hasanpour , Ghaderi Milad , Mardani Hamidreza , Joneghani Alizamen Salehifard , Dehkordi Ayda Hasanpour 
Published: July 2022

<p><strong>ABSTRACT</strong><br /><strong>BACKGROUND</strong>. Chronic kidney disease (CKD) is a progressive and irreversible disease that leads to end-stage renal disease. Many factors such as increased oxidative stress play a role in the occurrence of this complication.<br />Due to the effective role of the antioxidant defense system in controlling many of the complications in which oxidative stress is involved, the present study was conducted to evaluate the role of antioxidants in the prevention and treatment of chronic kidney disease.<br /><strong>METHODS</strong>. In this review study, studies using standard keywords in internal and external databases including: SID, Magiran, IranDoc, Medlib, Science Direct, PubMed, Scopus, Embase, Web of Science, Medline and Google Scholar search engine, were retrieved and selected without time limit.<br /><strong>RESULTS</strong>. Among the selected articles, 14 articles were eligible for inclusion in the study, which was performed on more than 20,000 people and several animal models of rats from 2005 onwards. The results showed that there is an inverse relationship between the concentration of antioxidant enzymes in the body and the intensity and progression of CKD. In severe cases, a significant decrease in the concentration of antioxidant enzymes in the body, as well as cofactors such as selenium, iron and zinc in the progressive and severe course of CKD has been observed.<br /><strong>CONCLUSIONS</strong>. The positive and significant effect of antioxidant compounds in chronic kidney disease is evident. The use of these compounds in the diet in the form of fruits, vegetables and grains, as well as the supply of iron and zinc and other minerals elements as cofactors for the action of enzymatic antioxidants has an effective role in the prevention and treatment of diseases by controlling free radicals.</p>
Impact of lockdown on changes in lifestyle, including changes in consumtion of selected groups of food products among the inhabitatns in the Mazowieckie Region
Authors: Pachocka L , El-Helou B , Wojda B , Mękus M 
Published: July 2022

<p><strong>ABSTRACT</strong><br />The aim of the study was to assess the lifestyle of a selected group of inhabitants of the Mazowieckie Voivodeship before the pandemic and to analyse the impact of lockdown on changes in lifestyle, including changes in the consumption of selected food products that are a source of vitamins and minerals. In August 2020, a survey was conducted based on a proprietary questionnaire. It was shown that during the lockdown period, 24.7% of women and 27.1% of men made changes in their lives. The changes concerned working hours, nature of work, hours of sleep, number of meals consumed and diet. The analysis of the diet showed a decrease in the consumption of vegetables, fruits and legumes in some respondents, which, with low frequency of consumption, may lead to a deficiency of dietary fibre, vitamin C, folic acid, polyphenols and potassium. The consumption of fish, spreadable fats, salt, sugar and drinks was not compliant with the recommendations of healthy eating. Public education about healthy lifestyles is essential to prevent complications from COVID-19.</p>
<p><strong>STRESZCZENIE</strong><br />Celem pracy była ocena stylu życia wybranej grupy mieszkańców województwa mazowieckiego przed pandemią oraz analiza wpływu lockdownu na zmiany w stylu życia, w tym na zmiany w spożyciu wybranych produktów spożywczych będących źródłem witamin i składników mineralnych. W sierpniu 2020 roku przeprowadzono, w oparciu o autorski kwestionariusz, badania ankietowe. Wykazano, że w okresie lockdownu 24,7% kobiet i 27,1% mężczyzn wprowadziło zmiany w swoim życiu. Zmiany dotyczyły godzin pracy, charakteru pracy, godzin snu, liczby spożywanych posiłków i sposobu żywienia. Analiza sposobu żywienia wykazała u części respondentów spadek spożycia warzyw, owoców, roślin strączkowych, co może prowadzić do niedoboru błonnika pokarmowego, witaminy C, kwasu foliowego, polifenoli oraz potasu. Niezgodne z zaleceniami zdrowego żywienia było spożycie ryb, tłuszczów do smarowania, soli, cukru i napojów. Aby zmniejszyć ryzyko powikłań związanych z COVID-19 niezbędna jest edukacja społeczeństwa w zakresie zdrowego stylu życia.</p>
ТРАНСФОРМАЦІЯ ЕКОНОМІЧНОГО ПРОСТОРУ УКРАЇНИ ЧЕРЕЗ ВІЙНУ
Authors: Плєтньов Михайло Васильович 
Published: July 2022

During the war, the spatial features of Ukraine developed independently, but the impact of the war on the economy requires a comprehensive analysis and assessment of economic, human and infrastructural losses at the regional level. Such an analysis also involves determining changes in the quality of life of the population in different regions of Ukraine and monitoring the existing changes taking place in the economic space of the country. The aim of the article is to determine the features of the transformation of Ukraine's economy during the war / after the war, taking into account the spatial aspect. Methods used in the research: comparison, systematization, sociological survey, etc. The hypothesis of the research was the assumption that due to the great losses and destruction of Ukraine's economy is the transformation of the economic space, and for its restoration it is appropriate to form areas of priority development along borders. Presenting the main material. According to the results of research on the peculiarities of the transformation of Ukraine's economy during the war / after the war, taking into account the spatial aspect, it was found that the war in Ukraine intensified migration processes, people move to the West or abroad. Due to the destruction of transport infrastructure, Ukraine's transport potential has been destroyed. Ukraine's economic losses also occurred due to damage and destruction of industrial infrastructure in Ukraine's industrial cities. It is established that the territories differ significantly in the degree of destruction, even in the scale of individual regions and cities. Therefore, the article presents a conditional gradation of the social quality of life of Ukrainians because of the war. In order to improve the quality of the population and despite the continuation of the war, it is necessary to plan the restoration and development of the regions, which are divided into three macro-regions. It is established that the destroyed regions need to be restored by introducing priority development areas for which state support areas have been identified. The originality and practical significance of the research lies in the formation of areas of priority development in the postwar period. Conclusions. It requires changes or approval of a new version of the State Strategy for Regional Development until 2027, changes in the formation and use of funds from the State Fund for Reconstruction and Regional Development, the search for donors in the EU and more. The further researches should be aimed at adjusting regulations on regional development
Perbedaan Jumlah Trombosit Pada Produk Trombosit Konsentrat (TC) Yang Berasal Dari Kantong Darah 350 Ml Dan 450 Ml di UTD PMI Kota Surabaya Tahun 2019
Authors: Amalia Yustisia , Samsulhadi Wiwid , Darmawati Darmawati 
Published: July 2022

Salah satu produk darah yang di hasilkan oleh UTD adalah trombosit, Untuk menjamin kualitas dan kuantitas trombosit dapat dinilai dari jumlah trombosit, suhu simpan, goyangan, permeabilitas kantong darah, dan pH serta ada tidaknya kontaminasi bakteri. Trombosit didapat dari Whole Blood( WB ) yang ditampung ke dalam sistem kantong darah steril dengan kantong transfer yang terintegrasi, kandungan trombosit tersuspensi didalam plasma, pengawasan mutu komponen trombosit dapat dilakukan dengan pemeriksaan jumlah trombosit terhadap produk TC yang telah dihasilkan.Tujuan penelitian ini adalah untuk mengetahui perbedaan jumlah trombosit per unit pada produk TC antara volume kantong darah 350 ml dan 450 ml. Penelitian menggunakan metode analitik observasional dengan penedekatan cross-sectional. Data yang didapatkan dianalisa secara langsung, penelitian ini dilaksanakan pada bulan Februari sampai October 2019 di Laboratorium Unit Transfusi Darah Palang Merah Indonesia Kota Surabaya. Sampel yang digunakan untuk penelitian ini merupakan hasil data pemeriksaan sampel produk TC yang berjumlah 44 sampel produk TC.Dari hasil penelitian membuktikan bahwa Jumlah trombosit dalam suatu produk TC yang dapat dikoleksi, dapat dipengaruhi oleh volume kantong darah whole blood sebagai bahan awal dari pembuatan suatu produk TC.
MODIFICATION OF THE BEST DIET (REGULARLY LOW ENERGY BALANCED) FOR OBESITY YOUTH
Authors: Wahyuningsih Retno , Darni Joyeti , Purbowati Meika , Suranadi Luh 
Published: July 2022

Background: Obesity is a teenage health problem that needs to be addressed. One of the handling efforts in overcoming excess weight is proper eating/diet settings. Research Methods: This type of research is a quasi-experimental design with a randomized pre-post test control group design. The research subjects used in this study were female adolescents aged 18-20 years with overweight nutritional status. The variables measured were body weight before and after treatment. The data obtained were tested statistically univariate to get an overview of the distribution of research variables and bivariate test to determine the effect of the REST diet on changes in body weight. Research Result: The results showed that the average weight loss in the treatment group was 0.92 kg, and the control group was 0.67 kg. From the results of the Paired-samples T-Test, a significant value of 0.000 (p <0.05) was obtained, which means that there was a substantial difference in the mean weight before and after treatment. Conclusion: The conclusion is that there is a difference in body weight before and after the study, but there is no effect of giving the REST diet on weight loss in obese adolescents.Background: Obesity is a teenage health problem that needs to be addressed. One of the handling efforts in overcoming excess weight is proper eating/diet settings. Research Methods: This type of research is a quasi-experimental design with a randomized pre-post test control group design. The research subjects used in this study were female adolescents aged 18-20 years with overweight nutritional status. The variables measured were body weight before and after treatment. The data obtained were tested statistically univariate to get an overview of the distribution of research variables and bivariate test to determine the effect of the REST diet on changes in body weight. Research Result: The results showed that the average weight loss in the treatment group was 0.92 kg, and the control group was 0.67 kg. From the results of the Paired-samples T-Test, a significant value of 0.000 (p <0.05) was obtained, which means that there was a substantial difference in the mean weight before and after treatment. Conclusion: The conclusion is that there is a difference in body weight before and after the study, but there is no effect of giving the REST diet on weight loss in obese adolescents.
UTILIZATION OF PRINT MEDIA AND VISUAL MEDIA ON ADOLESCENT KNOWLEDGE ABOUT ANEMIA
Authors: Hamidah Ratna , Kurniasari Ratih 
Published: July 2022

Background: Anemia decreases hemoglobin levels, hematocrit, and red blood cell counts below the average values set for individuals. Anemia is more common in young women because young women experience menstruation, and blood loss during menstruation can cause anemia. Adolescent boys and girls in their growth period need more energy, protein, and other nutrients than other age groups. Anemia in adolescents will impact decreased concentration in learning, decreased physical fitness, and impaired growth so that height and weight are not average. The common knowledge of adolescents about health information, especially about anemia, requires efforts to overcome the problem of anemia. This study aims to present an overview of the use of print media and audio-visual media for knowledge of adolescents about anemia. Research Methods: The method used by the author in this study is to use some of the existing literature related to the title of this study. Research Result: The results and discussion of this study will help readers and health workers understand the planning steps in education using print media and audio-visual media to adolescents about anemia. Conclusion: Using audio-visual media in animation and media in the form of guidebooks and flashcards is considered adequate for increasing knowledge of anemic adolescents, and flashcard media are still rarely used for learning media.
THE EFFECT OF NUTRITION EDUCATION WITH SOCIAL MEDIA ON CHANGES IN KNOWLEDGE AND DIET QUALITY IN OBESITY WOMEN
Authors: Alfitri Emilia , Kurniasari Ratih 
Published: July 2022

Background: Obesity in women is higher than in men. Changes in women's weight loss are influenced by many factors: nutritional knowledge and the quality of a healthy diet. The provision of nutrition education can use various media such as social media, which is currently many people, especially women. Research Methods: This study uses the literature review method by searching for journals through the Google Scholar portal with the SINTA index. Research Result: How is the effect of nutrition education with social media such as (Instagram and Whatsapp Group) on increasing nutritional knowledge in Obese Women. Conclusion: There is an effect of nutrition education with social media such as (Instagram and Whatsapp Group) on increasing nutritional knowledge, but not all of them can change diet quality behavior because to change diet quality requires encouragement, namely motivational interviewing and a long period of mentoring.
RELATIONSHIP OF SUGAR, SALT, AND FAT CONSUMPTION TO RATIO OF WAIST TO HIP AND BLOOD GLUCOSE LEVELS IN TYPE 2 DIABETES MELLITUS PATIENTS
Authors: Ismawanti Zuhria , Nurzihan Nastitie Cinintya , Permatasari Oktavina 
Published: July 2022

Background: Diabetes Mellitus (DM) is a chronic hyperglycemia condition that can affect all body systems. This situation is caused due to factors that inhibit insulin work or the amount decreases. Being overweight is also closely related to daily food intake, significantly contributing calories, such as sugar, salt, and fat. An indicator that can determine central obesity is the waist-to-hip ratio. Research Methods: This type of research is a cross-sectional study with an analytic observational study design. The sampling technique uses purposive sampling, and the total is 161 respondents. This research is in Gambirsari Public Health Center, Surakarta, Indonesia, in April 2020. Data on the Consumption of sugar, salt, and fat respondents used a Semi-Quantitative Food Frequency Questionnaire form and 24-hour food recall. Research Result: Test data analysis using Pearson using SPSS 23 software. Sugar consumption (p = 0.004, r = 0.229), salt (p = 0.001, r = 0.454), fat (p = 0.021, r = 0.181) indicates a relationship to the waist-to-hip ratio. Conclusion: Based on statistical analysis, it was found that there was a significant relationship between sugar, salt, and fat intake and the waist-to-hip ratio
ORGANOLEPTIC TEST OF PAPAYA JAMS (Carica papaya L.) WITH DIFFERENT SUGAR CONCENTRATIONS
Authors: Tessalonika Grace , Daningsih Entin , Mardiyyaningsih Nurdini 
Published: July 2022

Background: Papaya fruit has many benefits, is relatively abundant in West Kalimantan and has not been optimized. One of the processed foods that can raise maximum papaya utilization and extend the short shelf life of papaya is papaya jam. This study measures the effect of different sugar concentrations for acceptance using an organoleptic test on papaya jam (Carica papaya L.). Methods: The research on papaya jam used a Completely Randomized Design (CRD) with three treatments of sugar concentration (25, 45, and 65 g). Thirty untrained panelists were used as replicates. Papaya jam was evaluated using the organoleptic test to determine its acceptability of papaya jam. The assessment uses a line scalar sheet using six parameters: color, flavor, viscosity, papaya taste, sweetness level, and preference. The data of the organoleptic test were analyzed using the SAS CRD model. If there were effective treatments, then continued with the LSD test at an alpha of 0.05. This papaya jam was also analyzed for water and sugar content. Result: The results showed that the panelists favored papaya jam with a sugar concentration of 65 g. Moreover, it was chosen because it has the highest average value on color, flavor, viscosity, papaya taste, level of sweetness, and preference. Moreover, the papaya jam with a concentration of 65 g sugar resulted from it in the lowest water content and highest sugar content, according to SII year 1978. Conclusion: In the organoleptic test, papaya jam was accepted at the highest sugar concentration (65 g). Not only color, flavor viscosity, papaya taste, sweetness level and preference was significantly most elevated compared to other treatments, but papaya jam with a sugar concentration of 65 product maximum water content and minimum sugar content by SII (Indonesian Industrial Standard).