bluuebunny/crossref_metadata_2025_split huggingface dataset:
National surveillance of cancer survival in Iran (IRANCANSURV): Analysis of data of 15 cancer sites from nine population‐based cancer registries
Authors: Nemati Saeed , Saeedi Elnaz , Lotfi Fereshte , Nahvijou Azin , Mohebbi Elham , Ravankhah Zahra , Rezaeianzadeh Abbas , Yaghoobi‐Ashrafi Majid , Pirnejad Habbiballah , Golpazir Arash , Dolatkhah Roya , Alvand Saba , Ahmadi‐Tabatabaei Seyed Vahid , Cheraghi Maria , Weiderpass Elisabete , Bray Freddie , Coleman Michel P. , Etemadi Arash , Khosravi Ardeshir , Najafi Farid , Mohagheghi Mohammad Ali , Roshandel Gholamreza , Malekzadeh Reza , Zendehdel Kazem 
Published: July 2022

AbstractCancer survival is a key indicator for the national cancer control programs. However, survival data in the East Mediterranean region (EMR) are limited. We designed a national cancer survival study based on population‐based cancer registries (PBCRs) from nine provinces in Iran. The current study reports 5‐year net survival of 15 cancers in Iranian adults (15‐99 years) during 2014 to 2015 in nine provinces of Iran. We used data linkages between the cancer registries and the causes of death registry and vital statistics and active follow‐up approaches to ascertain the vital status of the patients. Five‐year net survival was estimated through the relative survival analysis. We applied the international cancer survival standard weights for age standardization. Five‐year survival was highest for prostate cancer (74.9%, 95% CI 73.0, 76.8), followed by breast (74.4%, 95% CI 72.50, 76.3), bladder (70.4%, 95% CI 69.0, 71.8) and cervix (65.2%, 95% CI 60.5, 69.6). Survival was below 25% for cancers of the pancreas, lung, liver, stomach and esophagus. Iranian cancer patients experience a relatively poor prognosis as compared to those in high‐income countries. Implementation of early detection programs and improving the quality of care are required to improve the cancer survival among Iranian patients. Further studies are needed to monitor the outcomes of cancer patients in Iran and other EMR countries.
Early versus delayed amniotomy with immediate oxytocin after Foley catheter cervical ripening in multiparous women with labor induction: A randomized controlled trial
Authors: Jamaluddin Arifah , Azhary Jerilee Mariam Khong , Hong Jesrine Gek Shan , Hamdan Mukhri , Tan Peng Chiong 
Published: July 2022

AbstractObjectiveTo evaluate immediate oxytocin and early amniotomy compared with delayed amniotomy after Foley catheter cervical ripening in multiparous women on intervention‐to‐delivery interval.MethodsThis randomized trial was conducted in Malaysia in 232 term multiparous women with balloon catheter–ripened cervixes (dilatation ≥3 cm), singleton fetus, cephalic presentation with intact membranes, and reassuring fetal heart rate tracing. They were randomized to immediate titrated intravenous oxytocin infusion and early amniotomy (116) or delayed amniotomy after 4 h of oxytocin (116). Primary outcome was intervention (oxytocin initiation)‐to‐delivery interval.ResultsOxytocin‐to‐delivery intervals were a median of 4.99 h (interquartile range [IQR], 3.21–7.82 h) versus 6.23 h (IQR, 4.50–8.45 h) (P < 0.001) for the early versus delayed amniotomy arms, respectively. Delivery rate at 4 h and 6 h after oxytocin infusion were 40 of 116 (35%) versus 22 of 116 (19%) (relative risk [RR], 1.82 [95% confidence interval (CI), 1.16–2.86], P = 0.011) and 77 of 116 (66%) versus 54 of 116 (47%) (RR, 1.43 [95% CI, 1.13–1.80], P = 0.003) for the early versus delayed amniotomy arms, respectively. Maternal satisfaction on birth process were 7 (IQR, 6–8) versus 7 (IQR, 7–8) (P = 0.006), uterine hyperstimulation rates were 10 of 116 (9%) versus 14 of 116 (12%) (RR, 0.71 [95% CI, 0.33–1.54]) (P = 0.519), and Cesarean delivery rates were 17 of 116 (15%) versus 19 of 116 (16%) (RR, 0.90 [95% CI, 0.49–1.63], P = 0.856) for the early versus delayed amniotomy arms, respectively.ConclusionIn multiparas at term following cervical ripening by Foley catheter, immediate oxytocin and early amniotomy compared with a scheduled 4‐h delay to amniotomy shortens the interval to birth and decreases uterine hyperactivity in labor but lowers maternal satisfaction. The cesarean delivery rate is not significantly reduced.Clinical Trial RegistrationThis study was registered with the International Standard Randomised Controlled Trial Number (ISRCTN) on September 29, 2020, with trial identification number: ISRCTN87066007 (https://doi.org/10.1186/ISRCTN87066007). The first participant was recruited on September 29, 2020, after ISRCTN registry confirmation was received.
Maternal asthma in Australian indigenous women and perinatal outcomes: A whole population–linked study
Authors: Brew Bronwyn K. , Gibberd Alison , Marks Guy B. , Murphy Vanessa E. , Jorm Louisa , Chambers Georgina M. , Hartz Donna , Eades Sandra , McNamara Bridgette 
Published: July 2022

AbstractObjectiveTo assess the association between maternal asthma and adverse perinatal outcomes in an Australian Indigenous population.MethodsThis prospective cohort study included all Indigenous mother and baby dyads for births from 2001 to 2013 in Western Australia (n = 25 484). Data were linked from Western Australia Births, Deaths, Midwives, Hospital, and Emergency Department collections. Maternal asthma was defined as a self‐reported diagnosis at an antenatal visit or hospitalization or emergency visit for asthma during pregnancy or less than 3 years before pregnancy. Associations with birth, labor, and pregnancy outcomes were assessed using generalized estimating equations. Asthma exacerbation during pregnancy and stratification by remoteness was also assessed.ResultsMaternal asthma was associated with placental abruption (adjusted odds ratio [aOR], 1.59 [95% confidence interval (CI), 1.07–2.35]), threatened preterm labor (aOR, 1.58 [95% CI, 1.39–1.79]), and emergency cesarean sections (aOR, 1.27 [95% CI, 1.13–1.44]). These risks increased further with an asthma exacerbation during pregnancy or if the mother was from a remote area. No associations were found for low birth weight, preterm birth, small for gestational age, or perinatal mortality.ConclusionMaternal asthma in Indigenous women is associated with an increased risk of emergency cesarean sections, placental abruption, and threatened preterm labor. These risks may be mitigated by improved management of asthma exacerbations during pregnancy.
Impact of an estrogen replacement regimen on live birth rate in frozen–thawed good‐quality embryo transfer
Authors: Şükür Yavuz Emre , Aslan Batuhan , Özmen Batuhan , Sönmezer Murat , Berker Bülent , Atabekoğlu Cem Somer , Aytaç Ruşen ,   MEETUP Team
Published: July 2022

AbstractObjectiveTo assess the impact of an estrogen replacement regimen on frozen embryo transfer (FET) cycle outcome.MethodsIn the present retrospective cohort study, data of infertile women undergoing FET with good‐quality embryos were reviewed. The first group received 2 mg of estradiol hemihydrate (EH) once daily for 6 to 7 days, then twice daily for 4 to 5 days, and then three times a day until embryo transfer. The second group received EH twice daily for 7 to 8 days, then three times a day. The third group received EH three times a day constantly. The main outcome measure was live birth rate.ResultsIn total, 394 FET cycles were included. The fixed 6‐mg group required the highest estradiol hemihydrate dose. The duration of estrogen treatment was significantly longer in the first group. Maximal endometrial thickness was highest in the second group (10.2 ± 1.3 mm vs. 9.6 ± 1.4 mm vs. 8.6 ± 0.9 mm, respectively; P < 0.001). The clinical pregnancy rates in the groups were 41.1%, 55.2%, and 42.2%, respectively (P = 0.035). Live birth rates were 40.8%, 50.9%, and 48.1%, respectively (P = 0.320).ConclusionIn FET cycles with hormone replacement therapy, a step‐up 4‐mg regimen provides thicker endometrium with optimal‐dose estrogen in an adequate time frame. The tendency for increased clinical pregnancy and live birth rates is remarkable.
Short-Term Carbohydrate Restriction Impairs Bone Formation at Rest and During Prolonged Exercise to a Greater Degree than Low Energy Availability
Authors: Fensham Nikita C. , Heikura Ida A. , McKay Alannah K.A. , Tee Nicolin , Ackerman Kathryn E. , Burke Louise M. 
Published: July 2022

ABSTRACT
Bone stress injuries are common in athletes, resulting in time lost from training and competition. Diets that are low in energy availability have been associated with increased circulating bone resorption and reduced bone formation markers, particularly in response to prolonged exercise. However, studies have not separated the effects of low energy availability per se from the associated reduction in carbohydrate availability. The current study aimed to compare the effects of these two restricted states directly. In a parallel group design, 28 elite racewalkers completed two 6-day phases. In the Baseline phase, all athletes adhered to a high carbohydrate/high energy availability diet (CON). During the Adaptation phase, athletes were allocated to one of three dietary groups: CON, low carbohydrate/high fat with high energy availability (LCHF), or low energy availability (LEA). At the end of each phase, a 25-km racewalk was completed, with venous blood taken fasted, pre-exercise, and 0, 1, 3 hours postexercise to measure carboxyterminal telopeptide (CTX), procollagen-1 N-terminal peptide (P1NP), and osteocalcin (carboxylated, gla-OC; undercarboxylated, glu-OC). Following Adaptation, LCHF showed decreased fasted P1NP (~26%; p &lt; 0.0001, d = 3.6), gla-OC (~22%; p = 0.01, d = 1.8), and glu-OC (~41%; p = 0.004, d = 2.1), which were all significantly different from CON (p &lt; 0.01), whereas LEA demonstrated significant, but smaller, reductions in fasted P1NP (~14%; p = 0.02, d = 1.7) and glu-OC (~24%; p = 0.049, d = 1.4). Both LCHF (p = 0.008, d = 1.9) and LEA (p = 0.01, d = 1.7) had significantly higher CTX pre-exercise to 3 hours post-exercise but only LCHF showed lower P1NP concentrations (p &lt; 0.0001, d = 3.2). All markers remained unchanged from Baseline in CON. Short-term carbohydrate restriction appears to result in reduced bone formation markers at rest and during exercise with further exercise-related increases in a marker of bone resorption. Bone formation markers during exercise seem to be maintained with LEA although resorption increased. In contrast, nutritional support with adequate energy and carbohydrate appears to reduce unfavorable bone turnover responses to exercise in elite endurance athletes. © 2022 The Authors. Journal of Bone and Mineral Research published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research (ASBMR).
Conformational distributions of helical perfluoroalkyl substances and impacts on stability
Authors: Mifkovic Maleigh , Van Hoomissen Daniel J. , Vyas Shubham 
Published: July 2022

AbstractPer‐ and polyfluoroalkyl substances (PFAS) have been widely used the past 70 years in numerous applications due to their chemical and thermal stability. Due to their robust stability, they are environmentally recalcitrant which made them one of the most persistent environmental contaminants. In addition to strong CF bond strength, oleophobicity, hydrophobicity, and high reduction–oxidation (redox) potential of PFAS has led to their inefficient degradation by traditional means. A characteristic of their structure is also their preference to adopt helical conformations along the carbon backbone, contrary to their hydrocarbon analogues. This work investigates the helical nature of perfluoroalkanes through their conformational distributions, especially as a benchmark for determining the impact of polar head groups, heteroatoms, and radical center on helical conformations. Since structure governs reactivity and molecular properties, it is important to assess if minor chemical perturbations in the structure will lead to changes in the conformations. Based on density functional theory calculations and comprehensive conformational distributions, it was concluded that the helicity is a local structural property which changes significantly with the presence of heteroatoms in the perfluoroalkyl chain as well as with the presence of radical centers.
Rational truncation, mutation, and halogenation of bradykinin neuropeptides as potent ACEII inhibitors by integrating molecular dynamics simulations, quantum mechanics calculations, and in vitro assays
Authors: Fu Jun , Chen Shenghui , Ni Zhong 
Published: July 2022

AbstractHuman angiotensin‐converting enzyme‐ii (ACEII) is involved in the brain renin‐angiotensin system and plays a key role in angiotensin metabolism and neural regulation. Here, we systematically investigated the intermolecular interaction of ACEII with its natural inhibitor bradykinin neuropeptide (BNP) at molecular level and found that the residue importance increases from peptide N‐ to C‐terminus; the four C‐terminal residues accumulatively account for ~70% total binding potency for BNP∆N to ACEII, which represent an N‐truncated tetrapeptide (BNP∆N) with comparable ACEII‐inhibitory activity with the full‐length BNP peptide. Mutagenesis analysis imparted that the mutation of BPPb∆N's two C‐terminal residues to phenylalanine (Phe) would largely impair its inhibitory activity, whereas such mutation on the two N‐terminal residues has only a moderate effect on the activity. The two N‐terminal Phe‐mutated tetrapeptides BNP∆N(I−2F) and BNP∆N(K−3F) were then used as templates and the ortho (o)‐, meta (m)‐, para (p)‐positions of the phenyl ring of their Phe residues were systematically substituted with different halogen types. The halogen substitution separately at the m‐position of BNP∆N(I−2F) Phe−2 residue and at the p‐position of BNP∆N(K−3F) Phe−3 residue can form a ternary halogen bonding system with ACEII His353/Lys368 residues and a binary bonding system with ACEII Glu403 residue, respectively. The [Br]Phe‐containing BNP∆N(I−2F‐mBr) and [I]Phe‐containing BNP∆N(K−3F‐pI) were determined to have high affinities for ACEII, which were improved considerably from their unsubstituted counterparts BNP∆N(I−2F) and BNP∆N(K−3F), respectively.
Arylsulfatase I is a prognostic biomarker for head and neck squamous cell carcinoma and Pan‐cancer
Authors: Shen Yiming , Wei Zhengyu , Zhou Chongchang , Song Jiangping , Wang Jianing , Wang Jiada , Wu Linrong , Fang Shenzhe , Shen Zhisen 
Published: July 2022

AbstractBackgroundSulfatase gene family members mediate various biological functions in tumor stroma and tumor cell environments. However, the expressions and prognostic value of Arylsulfatase I (ARSI), a sulfatase gene family member, in head and neck squamous cell carcinoma (HNSC) have not been fully established.MethodsArylsulfatase I expressions in pan‐cancer were profiled using publicly available databases. Then, univariate Cox regression, Kaplan–Meier, and the Pearson's correlation analyses were performed to determine correlations between ARSI expressions and cancer prognosis, immune cell status, and drug sensitivity. Gene set variation analysis (GSVA) and gene set enrichment analysis (GSEA) were used to assess the potential mechanisms underlying ARSI functions in HNSC.ResultsArylsulfatase I was highly expressed in 15 cancer types, with significant expressions in HNSC. Elevated ARSI levels were associated with worse prognostic outcomes in HNSC patients. In addition, GSVA and GSEA showed that ARSI was highly involved in tumor cell escape and inflammatory responses. Expressions of ARSI negatively correlated with tumor mutation burden or microsatellite instability and positively correlated with immune‐related genes. Elevated ARSI expressions conferred poor tolerance to daporinad and sinularin, but increased cell sensitivity to dasatinib and XAV939.ConclusionArylsulfatase I is a promising prognostic and therapeutic target for HNSC.
The prevalence of multiple drug resistance Escherichia coli and Klebsiella pneumoniae isolated from patients with urinary tract infections
Authors: Jalil Mays B. , Al Atbee Mohammed Younus Naji 
Published: July 2022

AbstractBackgroundUrinary tract infections (UTIs) and bacterial resistance to antibiotics is global health problem and a threat to public health in many countries.AimsThe study aimed to determine the prevalence of MDR Escherichia coli and Klebsiella pneumoniae in UTI patients.Materials & methodsThe midstream urine samples of 120 patients were collected and cultured as described by the protocols at the respective sample collection sites on MacConkey Blood agar. Samples were tested by using the fully automated VITEK 2 Compact system for Gram‐negative identification and detection of antimicrobial susceptibility of microorganisms.ResultsThe most prevalent pathogen was E. coli, which was found in 82 (68.3%) urine samples, followed by K. pneumonia, found in 38 (31.7%) urine samples. As far as antibiotic resistance is concerned, E. coli isolates were found to be highly resistant for ceftriaxone (89.0% of the isolates), ampicillin (86.6%), levofloxacin (82.9%), cefotaxime (79.3%), aztreonam (74.4%), ceftazidime (68.3%) and gentamicin, piperacillin, and trimethoprim‐sulfamethoxazole, 54.9 and 53.7%, respectively. The E. coli isolates were found to be relatively less resistant to imipenem (2.4%), cefepime (34.1%), and ciprofloxacin (35.4%). For K. pneumonia isolates, high resistance rates were observed for piperacillin (81.6%), levofloxacin (78.9%), ampicillin (76.3%), cefotaxime (73.7%), trimethoprim‐sulfamethoxazole (71.1%), ceftazidime (65.8%), gentamicin (63.2%), cefepime (50.0%), and aztreonam (44.7%). However, moderate resistance rates were detected for these were found to be less resistant for imipenem (13.2%), ceftriaxone (31.6%), and ciprofloxacin (36.8%).ConclusionE. coli and K. pneumoniae from the clinical isolates displayed high resistance to many antibiotics in UTI patients.
The predictive value of fibrinogen‐to‐albumin ratio in the active, severe active, and poor prognosis of systemic lupus erythematosus: A single‐center retrospective study
Authors: Dai Lu‐lu , Chen Cheng , Wu Jie , Cheng Jin‐feng , He Feng 
Published: July 2022

AbstractObjectiveTo evaluate the prediction and effect of fibrinogen‐to‐albumin ratio (FAR) on active, severe active, and poor prognosis of systemic lupus erythematosus (SLE).MethodsOne hundred and sixty‐eight patients with SLE who were treated in our hospital were enrolled, the clinical data, laboratory indexes, and disease prognosis of all patients were collected and analyzed.ResultsTriglyceride (TG), FAR, ESR, and anti‐dsDNA (+) were the influencing factors, while complement 3 (C3) was the protective factor of active SLE, the odds ratio (OR) values were 2.968, 3.698, 2.114, 2.727, and 0.652, respectively (p < 0.05). FAR, ESR, and anti‐dsDNA (+) were the influencing factors, while C3 was the protective factor of severe active SLE, the OR values were 3.791, 1.953, 2.187, and 0.742, respectively (p < 0.05). SLE disease activity index (SLEDAI), TG, FAR, and anti‐dsDNA (+) were the influencing factors, while C3 was the protective factor of poor prognosis SLE, the OR values were 3.024, 2.293, 3.012, 2.323, and 0.801, respectively (p < 0.05). FAR and FIB were positively correlated with SLEDAI, while ALB was negatively correlated with SLEDAI, the related coefficient (r) were 0.398, 0.267, −0.270, respectively. The receiver operating curve (ROC) analysis showed that the predictive values of FAR for active, severe active and poor prognosis SLE were 0.769, 0.769, and 0.734, respectively, were significant higher than FIB and ALB (p < 0.05).ConclusionFibrinogen‐to‐albumin ratio was an influencing factor of active, severe active, and poor prognosis SLE had higher predictive value than FIB and ALB for the activity and prognosis of SLE.
Genetic analyses of Vietnamese patients with oculocutaneous albinism
Authors: Thuong Ma Thi Huyen , Anh Luong Thi Lan , Nhung Vu Phuong , Ngoc Tran Thi Bich , Lan Hoang Thu , Phuong Doan Kim , Ha Nguyen Hai , Van Hai Nong , Ton Nguyen Dang 
Published: July 2022

AbstractBackgroundOculocutaneous albinism (OCA) is an autosomal recessive disease with hypopigmentation in skin, hair, and eyes, causing by the complete absence or reduction of melanin in melanocytes. Many types of OCA were observed based on the mutation in different causing genes relating to albinism. OCA can occur in non‐syndromic and syndromic forms, where syndromic OCA coexists with additional systemic consequences beyond hypopigmentation and visual‐associated symptoms.MethodsWe performed whole exome sequencing in seven affected individuals (P1‐P7) for mutation identification, and then, Sanger sequencing was used for verifications.ResultsAmong them, five patients (P1‐P5) have mutations on TYR gene including c.346C > T, c.929insC, c.115 T > C, and c.559_560ins25. The mutation on OCA2 and HPS1 genes was found in patient 6 (P6, OCA2 c.2323G > A) and patient 7 (P7, HPS1 c.972delC), respectively. Confirmation in parents (except the family of the elderly patient, P5) showed that the mother and the father in each family carried one of the variants that were detected in patients. Additionally, the effective genetic counseling was applied in the third pregnancy of a family with two OCA children (P1 and P2).ConclusionTo our best knowledge, this is the first case with a novel homozygous missense mutation (c.115 T > C, p.W39R) in the TYR gene. This study provides a broader spectrum of mutations linked to the oculocutaneous albinism, an additional scientific basis for diagnosis, and appropriate genetic counseling for risk couples.
Doctoral students' intention to use assessments in their career: The incremental role of self‐reported competence
Authors: Bergquist Becca K. , Keen Megan A. , Ingram Paul B. , Morris Nicole M. , Schmidt Adam T. 
Published: July 2022

AbstractObjectiveAttaining competence in assessment is a necessary step in graduate training and has been defined to include multiple domains of training relevant to this attainment. While important to ensure trainees meet these standards of training, it is critical to understand how and if competence shapes a trainees' professional identity, therein promoting lifelong competency.MethodsThe current study assessed currently enrolled graduate trainees' knowledge and perception of their capabilities related to assessment to determine if self‐reported and performance‐based competence would incrementally predict their intention to use assessment in their future above basic training characteristics and intended career interests.ResultsSelf‐reported competence, but not performance‐based competence, played an incremental role in trainees' intention to use assessments in their careers. Multiple graduate training characteristics and practice experiences were insignificant predictors after accounting for other relative predictors (i.e., intended career settings, integrated reports).ConclusionFindings are discussed about the critical importance of incorporating a hybrid competency‐capability assessment training framework to further emphasize the role of trainee self‐efficacy in hopes of promoting lifelong competence in their continued use of assessments.