bluuebunny/crossref_metadata_2025_split huggingface dataset:
Constraints on the Galactic Centre environment from Gaia hyper-velocity stars
Authors: Evans F A , Marchetti T , Rossi E M 
Published: February 2022

ABSTRACT
Following a dynamical encounter with Sgr A*, binaries in the Galactic Centre (GC) can be tidally separated and one member star ejected as a hyper-velocity star (HVS) with a velocity beyond the escape speed of the Milky Way. As GC-born objects located in more observationally accessible regions of the sky, HVSs offer insight into the stellar population in the inner parsecs of the Milky Way. We perform a suite of simulations ejecting stars from the GC, exploring how detectable HVS populations depend on assumptions concerning the GC stellar population, focusing on HVSs that would appear in current and/or future data releases from the Gaia space mission with precise astrometry and measured radial velocities. We show that predictions are sensitive to two parameters in particular: the shape of the stellar initial mass function (IMF) in the GC and the ejection rate of HVSs. The absence of confident HVS candidates in Gaia Data Release 2 excludes scenarios in which the HVS ejection rate is $\gtrsim 3\times 10^{-2} \, \mathrm{yr^{-1}}$. Stricter constraints will be placed on these parameters when more HVS candidates are unearthed in future Gaia data releases – assuming recent determinations of the GC IMF shape, one confident HVS at minimum is expected in Gaia DR3 and DR4 as long as the HVS ejection rate is greater than $\sim 10^{-3}$ and $\sim 10^{-5} \, \mathrm{yr^{-1}}$, respectively.
EDGE: What shapes the relationship between H i and stellar observables in faint dwarf galaxies?
Authors: Rey Martin P , Pontzen Andrew , Agertz Oscar , Orkney Matthew D A , Read Justin I , Saintonge Amélie , Kim Stacy Y , Das Payel 
Published: February 2022

ABSTRACT
We show how the interplay between feedback and mass-growth histories introduces scatter in the relationship between stellar and neutral gas properties of field faint dwarf galaxies ($M_{\star }\lessapprox 10^{6} \, \mbox{M}_\mathrm{\odot }$). Across a suite of cosmological, high-resolution zoomed simulations, we find that dwarf galaxies of stellar masses $10^5 \le M_{\star }\le 10^{6} \, \mbox{M}_\mathrm{\odot }$ are bimodal in their cold gas content, being either H i-rich or H i-deficient. This bimodality is generated through the coupling between (i) the modulation of H i contents by the background of ultraviolet radiation (UVB) at late times and (ii) the significant scatter in the stellar-to-halo mass relationship induced by reionization. Furthermore, our H i-rich dwarfs exhibit disturbed and time-variable neutral gas distributions primarily due to stellar feedback. Over the last four billion years, we observe order-of-magnitude changes around the median $M_{\mathrm{H\,\small {I} }}$, factor-of-a-few variations in H i spatial extents, and spatial offsets between H i and stellar components regularly exceeding the galaxies’ optical sizes. Time variability introduces further scatter in the $M_{\star }\!-\! M_{\mathrm{H\,\small {I} }}$ relation and affects a galaxy’s detectability in H i at any given time. These effects will need to be accounted for when interpreting observations of the population of faint, H i-bearing dwarfs by the combination of optical and radio wide, deep surveys.
Observations of PAHs in the atmospheres of discs and exoplanets
Authors: Ercolano Barbara , Rab Christian , Molaverdikhani Karan , Edwards Billy , Preibisch Thomas , Testi Leonardo , Kamp Inga , Thi Wing-Fai 
Published: February 2022

ABSTRACT
Polycyclic aromatic hydrocarbons (PAHs) play a key role in the chemical and hydrodynamical evolution of the atmospheres of exoplanets and planet-forming discs. If they can survive the planet formation process, PAHs are likely to be involved in pre-biotic chemical reactions eventually leading to more complex molecules such as amino acids and nucleotides, which form the basis for life as we know it. However, the abundance and specific role of PAHs in these environments is largely unknown due to limitations in sensitivity and range of wavelength of current and previous space-borne facilities. Upcoming infrared space spectroscopy missions, such as Twinkle and Ariel, present a unique opportunity to detect PAHs in the atmospheres of exoplanets and planet-forming discs. In this work, we present synthetic observations based on conservative numerical modelling of typical planet-forming discs and a transiting hot Saturnian planet around solar-type star. Our models show that Twinkle and Ariel might both be able to detect the 3.3 $\mu$m PAH feature within reasonable observing time in discs and transiting planets, assuming that PAHs are present with an abundance of at least one-tenth of the interstellar medium value.
Standardizing Platinum Dainotti-correlated gamma-ray bursts, and using them with standardized Amati-correlated gamma-ray bursts to constrain cosmological model parameters
Authors: Cao Shulei , Dainotti Maria , Ratra Bharat 
Published: February 2022

ABSTRACTWe show that the Platinum gamma-ray burst (GRB) data compilation, probing the redshift range 0.553 ≤ z ≤ 5.0, obeys a cosmological-model-independent three-parameter Fundamental Plane (Dainotti) correlation and so is standardizable. While they probe the largely unexplored z ∼ 2.3–5 part of cosmological redshift space, the GRB cosmological parameter constraints are consistent with, but less precise than, those from a combination of baryon acoustic oscillation (BAO) and Hubble parameter [H(z)] data. In order to increase the precision of GRB-only cosmological constraints, we exclude common GRBs from the larger Amati-correlated A118 data set composed of 118 GRBs and jointly analyse the remaining 101 Amati-correlated GRBs with the 50 Platinum GRBs. This joint 151 GRB data set probes the largely unexplored z ∼ 2.3–8.2 region; the resulting GRB-only cosmological constraints are more restrictive, and consistent with, but less precise than, those from H(z) + BAO data.
EWS splicing regulation contributes to balancingFoxp1isoforms required for neuronal differentiation
Authors: Verdile Veronica , Svetoni Francesca , La Rosa Piergiorgio , Ferrante Gabriele , Cesari Eleonora , Sette Claudio , Paronetto Maria Paola 
Published: February 2022

AbstractAlternative splicing is a key regulatory process underlying the amplification of genomic information and the expansion of proteomic diversity, particularly in brain. Here, we identify the Ewing sarcoma protein (EWS) as a new player of alternative splicing regulation during neuronal differentiation. Knockdown of EWS in neuronal progenitor cells leads to premature differentiation. Transcriptome profiling of EWS-depleted cells revealed global changes in splicing regulation. Bioinformatic analyses and biochemical experiments demonstrated that EWS regulates alternative exons in a position-dependent fashion. Notably, several EWS-regulated splicing events are physiologically modulated during neuronal differentiation and EWS depletion in neuronal precursors anticipates the splicing-pattern of mature neurons. Among other targets, we found that EWS controls the alternative splicing of the forkhead family transcription factor FOXP1, a pivotal transcriptional regulator of neuronal differentiation, possibly contributing to the switch of gene expression underlying the neuronal differentiation program.
Detection of tumor-specific DNA methylation markers in the blood of patients with pituitary neuroendocrine tumors
Authors: Herrgott Grayson A , Asmaro Karam P , Wells Michael , Sabedot Thais S , Malta Tathiane M , Mosella Maritza S , Nelson Kevin , Scarpace Lisa , Barnholtz-Sloan Jill S , Sloan Andrew E , Selman Warren R , deCarvalho Ana C , Poisson Laila M , Mukherjee Abir , Robin Adam M , Lee Ian Y , Snyder James , Walbert Tobias , Rosenblum Mark , Mikkelsen Tom , Bhan Arti , Craig John , Kalkanis Steven , Rock Jack , Noushmehr Houtan , Castro Ana Valeria 
Published: February 2022

Abstract

Background
DNA methylation abnormalities are pervasive in pituitary neuroendocrine tumors (PitNETs). The feasibility to detect methylome alterations in circulating cell-free DNA (cfDNA) has been reported for several central nervous system (CNS) tumors but not across PitNETs. The aim of the study was to use the liquid biopsy (LB) approach to detect PitNET-specific methylation signatures to differentiate these tumors from other sellar diseases.

Methods
We profiled the cfDNA methylome (EPIC array) of 59 serum and 41 plasma LB specimens from patients with PitNETs and other CNS diseases (sellar tumors and other pituitary non-neoplastic diseases, lower-grade gliomas, and skull-base meningiomas) or nontumor conditions, grouped as non-PitNET.

Results
Our results indicated that despite quantitative and qualitative differences between serum and plasma cfDNA composition, both sources of LB showed that patients with PitNETs presented a distinct methylome landscape compared to non-PitNETs. In addition, LB methylomes captured epigenetic features reported in PitNET tissue and provided information about cell-type composition. Using LB-derived PitNETs-specific signatures as input to develop machine-learning predictive models, we generated scores that distinguished PitNETs from non-PitNETs conditions, including sellar tumor and non-neoplastic pituitary diseases, with accuracies above ~93% in independent cohort sets.

Conclusions
Our results underpin the potential application of methylation-based LB profiling as a noninvasive approach to identify clinically relevant epigenetic markers to diagnose and potentially impact the prognostication and management of patients with PitNETs.
Artificial Intelligence-based Radiomics in the Era of Immuno-oncology
Authors: Kang Cyra Y , Duarte Samantha E , Kim Hye Sung , Kim Eugene , Park Jonghanne , Lee Alice Daeun , Kim Yeseul , Kim Leeseul , Cho Sukjoo , Oh Yoojin , Gim Gahyun , Park Inae , Lee Dongyup , Abazeed Mohamed , Velichko Yury S , Chae Young Kwang 
Published: February 2022

AbstractThe recent, rapid advances in immuno-oncology have revolutionized cancer treatment and spurred further research into tumor biology. Yet, cancer patients respond variably to immunotherapy despite mounting evidence to support its efficacy. Current methods for predicting immunotherapy response are unreliable, as these tests cannot fully account for tumor heterogeneity and microenvironment. An improved method for predicting response to immunotherapy is needed. Recent studies have proposed radiomics—the process of converting medical images into quantitative data (features) that can be processed using machine learning algorithms to identify complex patterns and trends—for predicting response to immunotherapy. Because patients undergo numerous imaging procedures throughout the course of the disease, there exists a wealth of radiological imaging data available for training radiomics models. And because radiomic features reflect cancer biology, such as tumor heterogeneity and microenvironment, these models have enormous potential to predict immunotherapy response more accurately than current methods. Models trained on preexisting biomarkers and/or clinical outcomes have demonstrated potential to improve patient stratification and treatment outcomes. In this review, we discuss current applications of radiomics in oncology, followed by a discussion on recent studies that use radiomics to predict immunotherapy response and toxicity.
FDA Approval Summary: Axicabtagene Ciloleucel for Relapsed or Refractory Follicular Lymphoma
Authors: Bouchkouj Najat , Zimmerman Megan , Kasamon Yvette L , Wang Cong , Dai Tianjiao , Xu Zhenzhen , Wang Xiaofei , Theoret Marc , Purohit-Sheth Tejashri , George Bindu 
Published: February 2022

AbstractIn March 2021, the U.S. Food and Drug Administration granted accelerated approval to axicabtagene ciloleucel, a CD19-directed chimeric antigen receptor T-cell therapy, for the treatment of adult patients with relapsed or refractory follicular lymphoma (r/r FL) after at least 2 lines of systemic therapy. Approval was based on ZUMA-5, a single-arm, open-label, multicenter trial that evaluated a single infusion of axicabtagene ciloleucel, preceded by lymphodepleting chemotherapy with cyclophosphamide and fludarabine, in this population. Efficacy was based on objective response rate (ORR) and duration of response (DOR) as determined by an independent review committee. Among 81 patients in the primary efficacy analysis, having a median of 3 (range 2-9) prior lines of systemic therapy, the ORR was 91% (95% confidence interval [CI]: 83-96) with a complete remission (CR) rate of 60% and a median time-to-response of 1 month. The median DOR was not reached, and the 1-year rate of continued remission was 76% (95% CI: 64-85). For all leukapheresed patients with FL in this trial (n = 123), the ORR was 89% (95% CI: 83-94) with a CR rate of 62%. Among 146 patients with indolent lymphoma evaluated for safety, cytokine release syndrome occurred in 84% (Grade ≥3, 8%) and neurological toxicities occurred in 77% (Grade ≥3, 21%), leading to implementation of a risk evaluation and mitigation strategy. Serious adverse reactions occurred in 48%. Post-marketing studies will further evaluate clinical benefit in patients with r/r FL and long-term safety.
MicroRNA828 negatively regulates lignin biosynthesis in stem of Populus tomentosa through MYB targets
Authors: Wang Xianqiang , Yao Shu , Htet Win Pa Pa Myo , Yue Yuchen , Zhang Zhuanzhuan , Sun Kuan , Chen Sijie , Luo Keming , Fan Di 
Published: February 2022

Abstract
Lignin biosynthesis in the sclerenchyma cells is strictly controlled by a complex network of genetic and environmental signals. In the last decades, the transcriptional regulation of lignin synthesis in woody species has been established. However, the role of microRNA-mediated post-transcriptional modulation in secondary cell wall biosynthesis remains poorly understood. Here, we identified a microRNA, miR828, involved in the regulation specific to lignin biosynthesis during stem development in Populus tomentosa Carr. miR828 is preferentially expressed in the secondary vascular tissues during stem development. Two MYB genes (MYB171 and MYB011) were validated as direct targets of miR828 by degradome analysis and green fluorescent protein signal detection. Overexpression of miR828 in poplar downregulated genes for lignin biosynthesis, resulting in reduced lignin content in cell walls. Conversely, suppression of miR828 in plants by the short tandem target mimics elevated the expression of lignin biosynthetic genes and increased lignin deposition. We further revealed that poplar MYB171, as the most abundant miR828 target in the stem, is a positive regulator for lignin biosynthesis. Transient expression assays showed that both MYB171 and MYB011 activated PAL1 and CCR2 transcription, whereas the introduction of miR828 significantly suppressed their expression that was induced by MYB171 or MYB011. Collectively, our results demonstrate that the miR828-MYBs module precisely regulates lignin biosynthesis during the stem development in P. tomentosa through transcriptional and post-transcriptional manners.
Characteristics of Nursing Home Resident Movement Patterns: Results from the TEAM-UP Trial
Authors: Kennerly Susan M. , Sharkey Phoebe D. , Horn Susan D. , Zheng Tianyu , Alderden Jenny , Sabol Valerie K. , Rowe Meredeth , Yap Tracey L. 
Published: February 2022

ABSTRACT

OBJECTIVE
To determine movement patterns of nursing home residents, specifically those with dementia or obesity, to improve repositioning approaches to pressure injury (PrI) prevention.

METHODS
A descriptive exploratory study was conducted using secondary data from the Turn Everyone And Move for Ulcer Prevention (TEAM-UP) clinical trial examining PrI prevention repositioning intervals. K-means cluster analysis used the average of each resident’s multiple days’ observations of four summary mean daily variables to create homogeneous movement pattern clusters. Growth mixture models examined movement pattern changes over time. Logistic regression analyses predicted resident and nursing home cluster group membership.

RESULTS
Three optimal clusters partitioned 913 residents into mutually exclusive groups with significantly different upright and lying patterns. The models indicated stable movement pattern trajectories across the 28-day intervention period. Cluster profiles were not differentiated by residents with dementia (n = 450) or obesity (n = 285) diagnosis; significant cluster differences were associated with age and Braden Scale total scores or risk categories. Within clusters 2 and 3, residents with dementia were older (P < .0001) and, in cluster 2, were also at greater PrI risk (P < .0001) compared with residents with obesity; neither group differed in cluster 1.

CONCLUSIONS
Study results determined three movement pattern clusters and advanced understanding of the effects of dementia and obesity on movement with the potential to improve repositioning protocols for more effective PrI prevention. Lying and upright position frequencies and durations provide foundational knowledge to support tailoring of PrI prevention interventions despite few significant differences in repositioning patterns for residents with dementia or obesity.
Persistent Postgastrectomy Hypoglycemia Unawareness in Patients With Gastric Cancer Unveiled by a Prospective Study
Authors: Kubota Takeshi , Yubakami Masayuki , Ushigome Emi , Ohashi Takuma , Shoda Katsutoshi , Konishi Hirotaka , Shiozaki Atsushi , Fujiwara Hitoshi , Okamoto Kazuma , Fukui Michiaki , Otsuji Eigo 
Published: February 2022

Objective:
Late dumping syndrome is a common postgastrectomy complication characterized by reactive hypoglycemia. This study aimed to explore the glycemic trend in patients who underwent gastrectomy for gastric cancer and clarify its changes over time in association with postgastrectomy symptoms.

Summary Background Data:
Changes over time in glycemic trend in association with postgastrectomy symptoms have not been evaluated.

Methods:
We conducted a prospective study of 71 patients who underwent curative gastrectomy for gastric cancer between November 2017 and April 2020. The patients underwent continuous glucose monitoring twice—at 1- and 12-month postgastrectomy—and were assessed using the Post-Gastrectomy Syndrome Assessment Scale 37-item questionnaire (PGSAS-37) at 1-, 6-, and 12-month postgastrectomy.

Results:
Our results revealed that hypoglycemia (<70 mg/dL), especially nocturnal hypoglycemia (00:00−06:00), frequently occurred even at 12-month postgastrectomy. Hypoglycemia improved in total gastrectomy patients but remained unchanged in distal gastrectomy patients, which was still high in both groups at 12-month postgastrectomy. Glycemic variability (SD of the glycemic trend) was exacerbated in both gastrectomy groups. However, the PGSAS-37 symptom scores remained unchanged, and the living status and quality of life tended to improve. Hypoglycemia unawareness, including postprandial hypoglycemia without symptoms and nocturnal hypoglycemia, was evident even 12-month postgastrectomy.

Conclusions:
Persistent postgastrectomy hypoglycemia unawareness, including late dumping syndrome without symptoms and nocturnal hypoglycemia, should be recognized as an important issue in postgastrectomy syndrome. Therefore, meticulous long-term evaluation for glycemic trends and care of patients is required.
Upregulation of transient receptor potential cation channel subfamily M member-3 in bladder afferents is involved in chronic pain in cyclophosphamide-induced cystitis
Authors: Zhao Mengmeng , Liu Lei , Chen Zhenghao , Ding Ning , Wen Jiliang , Liu Jiaxin , Ge Nan , Zhang Xiulin 
Published: February 2022

Abstract
The transient receptor potential cation channel subfamily M member-3 (TRPM3) channel is a recently recognized noxious heat sensor that is involved in inflammatory thermal hyperalgesia. To examine its involvement in the development of hyperalgesia in interstitial cystitis/painful bladder syndrome (IC/PBS), rats with cyclophosphamide (CYP)-induced chronic cystitis were used as a model of IC/PBS. Mechanical and thermal hyperalgesia in lower abdominal region overlying the bladder in CYP rats were measured using von Frey filaments and radiant heat, respectively. Transient receptor potential cation channel subfamily M member-3 expression at the mRNA, protein, and functional levels in dorsal root ganglion neurons innervating the bladder was detected using RNA in situ hybridization (RNAscope), Western blotting, immunohistochemistry, and Ca2+ imaging, respectively. Transient receptor potential cation channel subfamily M member-3 channels were expressed on most of the bladder primary afferent nerve terminals containing calcitonin gene–related peptide and their cell bodies in L6-S1 dorsal root ganglion. Activation of TRPM3 in the bladder wall by its specific agonist pregnenolone sulphate or CIM0216 induced spontaneous bladder pain, calcitonin gene–related peptide release, and neurogenic inflammation that was evidenced by edema, plasma extravasation, inflammatory cell accumulation, and mast cell infiltration. In CYP rats, pretreatment with the TRPM3 antagonist primidone (2 mg/kg, i.p.) significantly alleviated the mechanical and thermal hyperalgesia, bladder submucosal edema, mast cell infiltration, and bladder hyperactivity. Cyclophosphamide-induced cystitis was associated with TRPM3 upregulation at the mRNA, protein, and functional levels in bladder afferent neurons. Our results suggest that upregulation of TRPM3 channels is involved in the development of chronic pain in CYP-induced cystitis, and targeting TRPM3 may be a pharmacological strategy for treating bladder pain in IC/PBS.
Preoperative Imaging of Temporoparietal Scalp Thickness Predicts Off-the-Ear Sound Processor Retention in Cochlear Implants With Diametric Magnets
Authors: Adkins Weston J. , Henrie Tanner , Nassiri Ashley M. , Neff Brian A. , Carlson Matthew L. , Driscoll Colin L. W. , Saoji Aniket A. 
Published: February 2022

Objective:
To determine if temporoparietal scalp thickness assessed via preoperative imaging predicts retention events in patients who have cochlear implants with diametric magnets and various sound processor types.

Study Design:
Retrospective chart and radiological review.

Setting:
Tertiary referral center.

Patients:
One hundred forty-three adult patients who have cochlear implants with diametric magnets.

Main Outcome Measures:
Skin flap thickness, retention events, body mass index (BMI), and magnet strength.

Results:
Of 42 patients with the most recent generation off-the-ear sound processor (OTE2), 13 (31.0%) had retention events. Of patients with a temporoparietal scalp thickness less than 8 mm, all patients could ultimately retain the device, though one of 26 was noted to have tenuous retention. Of patients with 8 to 10 mm skin flaps, 3 of 6 (50%) could not retain the device, and with more than 10 mm skin flaps, 7 of 10 (70%) could not retain the device. In the more than 10 mm group, two additional patients could not either retain the device at initial activation or were noted to have tenuous retention. Of 124 patients with behind-the-ear (BTE) sound processors, only 2 (1.6%) could not retain the device at initial activation, and 3 (2.4%) exhibited tenuous retention after 3 months of device use. Results from the first generation off-the-ear sound processor (OTE1) are also reported.

Conclusions:
Temporoparietal scalp thickness measured by preoperative imaging is associated with processor retention for patients with the OTE2 sound processor and diametric magnets. All patients with less than 8 mm scalp thickness could retain the OTE2, while 50% of patients with 8 to 10 mm scalp thickness and 70% with more than 10 mm scalp thickness could not retain the device. Patients should be counseled regarding their sound processor choice and/or considered candidates for skin flap reduction or other intervention as indicated. Retention events with BTE processors are rare.