bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of local cryotherapy on systemic endothelial activation, dysfunction, and vascular inflammation in adjuvant-induced arthritis (AIA) rats
Authors: Peyronnel C. , Totoson P. , Petitcolin V. , Bonnefoy F. , Guillot X. , Saas P. , Verhoeven F. , Martin H. , Demougeot C. 
Published: April 2022

Abstract
Aim
This study explored the systemic vascular effects of local cryotherapy with a focus on endothelial changes and arterial inflammation in the model of rat adjuvant-induced arthritis (AIA).

Methods
Cryotherapy was applied twice a day on hind paws of AIA rats from the onset of arthritis to the acute inflammatory phase. Endothelial activation was studied in the aorta by measuring the mRNA levels of chemokines (CXCL-1, MCP-1 (CCL-2), MIP-1α (CCL-3)) and adhesion molecules (ICAM-1, VCAM-1) by qRT-PCR. Endothelial dysfunction was measured in isolated aortic and mesenteric rings. Aortic inflammation was evaluated via the mRNA expression of pro-inflammatory cytokines (TNF-α, IL-6) by qRT-PCR and leucocyte infiltration analysis (flow cytometry). Plasma levels of TNF-α, IL-6, IL-1β, IL-17A, and osteoprotegerin (OPG) were measured using Multiplex/ELISA.

Results
AIA was associated with an increased aortic expression of CXCL-1 and ICAM-1 as well as an infiltration of leucocytes and increased mRNA expression of IL-6, IL-1β, and TNF-α. Local cryotherapy, which decreased arthritis score and structural damages, reduced aortic mRNA expression of CXCL-1, IL-6, IL-1β, and TNF-α, as well as aortic infiltration of leucocytes (T lymphocytes, monocytes/macrophages, neutrophils) and improved acetylcholine-induced vasorelaxation in the aorta and mesenteric arteries. Plasma levels of IL-17A and OPG were significantly reduced by cryotherapy, while the number of circulating leucocytes was not. IL-17A levels positively correlated with endothelial activation and dysfunction.

Conclusion
In the AIA model, local cryotherapy reduced systemic endothelial activation, immune cell infiltration, and endothelial dysfunction. Mechanistically, the reduction of circulating levels of IL-17A appears as the possible link between joint cooling and the remote vascular effects.
Validation of aortic valve pressure gradient quantification using semi-automated 4D flow CMR pipeline
Authors: Grafton-Clarke Ciaran , Njoku Paul , Aben Jean-Paul , Ledoux Leon , Zhong Liang , Westenberg Jos , Swift Andrew , Archer Gareth , Wild James , Hose Rod , Flather Marcus , Vassiliou Vassilios S. , Garg Pankaj 
Published: April 2022

Abstract
Objective
Doppler echocardiographic aortic valve peak velocity and peak pressure gradient assessment across the aortic valve (AV) is the mainstay for diagnosing aortic stenosis. Four-dimensional flow cardiovascular magnetic resonance (4D flow CMR) is emerging as a valuable diagnostic tool for estimating the peak pressure drop across the aortic valve, but assessment remains cumbersome.
We aimed to validate a novel semi-automated pipeline 4D flow CMR method of assessing peak aortic value pressure gradient (AVPG) using the commercially available software solution, CAAS MR Solutions, against invasive angiographic methods.

Results
We enrolled 11 patients with severe AS on echocardiography from the EurValve programme. All patients had pre-intervention doppler echocardiography, invasive cardiac catheterisation with peak pressure drop assessment across the AV and 4D flow CMR.
The peak AVPG was 51.9 ± 35.2 mmHg using the invasive pressure drop method and 52.2 ± 29.2 mmHg for the 4D flow CMR method (semi-automated pipeline), with good correlation between the two methods (r = 0.70, p = 0.017).
Assessment of AVPG by 4D flow CMR using the novel semi-automated pipeline method shows excellent agreement to invasive assessment when compared to doppler-based methods and advocate for its use as complementary to echocardiography.
Aggressive giant prolactinoma: a case report
Authors: Borhan Marisa Khatijah , Tan Florence Hui Sieng 
Published: April 2022

Abstract
Background
Managing treatment-resistant aggressive giant prolactinoma can be challenging, as the diagnosis is often complex, and treatment beyond dopamine agonists, surgery, and radiotherapy is limited.

Case presentation
A 21-year-old Malay woman first presented to our hospital at the age of 16 years with 1-year history of reduced vision and 2 years of amenorrhea. Her baseline prolactin level was 255,894 µIU/mL with secondary hypogonadism, and pituitary magnetic resonance imaging revealed a giant prolactinoma (2.8 × 3.2 × 4.2 cm3) with suprasellar extension and optic chiasmal compression. She was initially treated with cabergoline, and reductions in the prolactin level and tumor mass were achieved, leading to vision improvement and resumption of normal menstruation. However, she developed recurrent tumor growth and hyperprolactinemia, causing relapse of symptoms, and she needed surgery. Eventually, despite three tumor debulking surgeries and escalation of cabergoline doses up to 1 mg/day, her tumor progressed with aggressive characteristics. Following a multidisciplinary meeting, the patient is initiated on temozolomide therapy after considering the long-term side effects of radiotherapy in her case.

Conclusion
This case highlights the importance of early identification of treatment-resistant prolactinoma and the need for a multidisciplinary approach in managing aggressive prolactinoma in young patients, particularly regarding timely implementation of temozolomide therapy.
A scenario-based volcanic hazard assessment for the Mount Meager Volcanic Complex, British Columbia
Authors: Warwick Rachel , Williams-Jones Glyn , Kelman Melanie , Witter Jeffrey 
Published: April 2022

AbstractThe Mount Meager Volcanic Complex (Mount Meager) is a glacier-clad stratovolcanic system in southwestern British Columbia which last erupted over 2400 years ago (VEI 4). While this is Canada’s most recent major explosive eruption, most past research on Mount Meager has focused on its numerous and large volume landslides and thus the volcanic hazard characteristics remain understudied. Here we present a suite of scenario-based hazard maps and an assessment addressing a range of potential future explosive eruptions and associated hazards. In order to overcome limited knowledge of the eruptive history, numerical models have been used to simulate the primary syneruptive hazards of concern (dome-collapse pyroclastic density currents, lahars and tephra fallout) largely utilizing eruption parameters from analogous volcanoes, i.e., glacier-clad stratovolcanoes in a subduction zone setting. This study provides a framework for similar volcanic hazard studies where geologic data is limited, funds are minimal, and access is difficult. Furthermore, this sets the stage for recognizing volcanic hazards in the Canadian landscape, providing a resource to prepare for and mitigate potential impacts well in advance of a crisis situation.
5-ASA induced interstitial nephritis in patients with inflammatory bowel disease: a systematic review
Authors: Moss James G. , Parry Christopher M. , Holt Richard C. L. , McWilliam Stephen J. 
Published: April 2022

Abstract
Background
Acute interstitial nephritis (AIN) is an important cause of kidney injury accounting for up to 27% of unexplained renal impairment. In up to 70% of cases, drugs, including aminosalicylates, are reported as the underlying cause. Following two recent paediatric cases of suspected mesalazine induced AIN within our own department, we performed a systematic review of the literature to address the following question: In patients with inflammatory bowel disease (IBD), is interstitial nephritis associated with 5-aminosalicylate (5-ASA) treatment? Our primary objective was to identify the number of cases reported in the literature of biopsy-proven 5-ASA induced interstitial nephritis, in children and adults with IBD. We also aimed to identify which variables influence the onset, severity and recovery of 5-ASA interstitial nephritis.

Methods
Embase and PubMed databases were searched from inception to 07/10/20. Search terms had three main themes: “inflammatory bowel disease”, “interstitial nephritis” and “aminosalicylates”. Studies were included if they reported an outcome of AIN, confirmed on biopsy, suspected to be secondary to a 5-ASA drug in those with IBD. A narrative synthesis was performed.

Results
Forty-one case reports were identified. Mesalazine was the most frequently reported aminosalicylate associated with AIN (95%). The median duration of treatment before AIN was diagnosed was 2.3 years (Interquartile Range (IQR) 12–48 months). The median rise in creatinine was 3.3 times the baseline measurement (IQR 2.5–5.5). Aminosalicylate withdrawal and steroids were the most frequently used treatments. Despite treatment, 15% of patients developed end-stage renal failure.

Conclusions
AIN is a serious adverse drug reaction associated with aminosalicylates, with mesalazine accounting for most reports. The current guidance of annual monitoring of renal function may not be sufficient to identify cases early. Given the severity of AIN and reports in the literature that early treatment with steroids may be beneficial, we would recommend at least 6 monthly monitoring of renal function.
PROSPERO registration number CRD42020205387.
A comparison of knowledge and attitude toward mental illness among secondary school students and teachers
Authors: Al Omari Omar , Khalaf Atika , Al Hashmi Iman , Al Qadire Mohammad , Abu Shindi Yousef , Al Sabei Sulaiman , Matani Nasir , Jesudoss Devanprabudoss 
Published: April 2022

AbstractAimThe current study aimed to assess and compare the level of knowledge and attitude towards mental illness between secondary school students and their teachers in Oman.MethodsAn online survey was carried out to collect data from 400 students and 411 teachers about their knowledge and attitudes toward people with mental illness. Two independent case studies about depression and schizophrenia were also tested.ResultsStudents have a poor knowledge of mental illness compared with their teachers, as more than half scored less than 60% compared with 16.5% of the teachers. More than two-thirds of the students (80%) and teachers (76.4%) have a low or minor positive attitude toward people with mental illness. The study identified significant differences in knowledge in favour of teachers, although the opposite was found regarding attitudes.ConclusionsSince students spend a significant amount of time in school, bridging the gap between teachers' and students’ knowledge and attitudes toward mental illness is an essential part in enhancing the knowledge and attitudes of the students. In addition, knowledgeable teachers with positive attitude can assist in early identification of mental illnesses and help students when needed. In turn, students who possess knowledge and positive attitude toward mental illness can share their concerns with their teachers. In the presence of such accepting and cooperative environment, the stigma can be decreased and early detection of mental illness and help-seeking behaviour can be promoted.
Reinfection in patients with COVID-19: a systematic review
Authors: Ren Xiangying , Zhou Jie , Guo Jing , Hao Chunmei , Zheng Mengxue , Zhang Rong , Huang Qiao , Yao Xiaomei , Li Ruiling , Jin Yinghui 
Published: April 2022

AbstractBackgroundWith the continuation of the COVID-19 pandemic, some COVID-19 patients have become reinfected with the virus. Viral gene sequencing has found that some of these patients were reinfected by the different and others by same strains. This has raised concerns about the effectiveness of immunity after infection and the reliability of vaccines. To this end, we conducted a systematic review to assess the characteristics of patients with reinfection and possible causes.MethodsA systematic search was conducted across eight databases: PubMed, Embase, Web of Science, The Cochrane Library, CNKI, WanFang, VIP and SinoMed from December 1, 2019 to September 1, 2021.The quality of included studies were assessed using JBI critical appraisal tools and Newcastle–Ottawa Scale.ResultsThis study included 50 studies from 20 countries. There were 118 cases of reinfection. Twenty-five patients were reported to have at least one complication. The shortest duration between the first infection and reinfection was 19 days and the longest was 293 days. During the first infection and reinfection, cough (51.6% and 43.9%) and fever (50% and 30.3%) were the most common symptoms respectively. Nine patients recovered, seven patients died, and five patients were hospitalized, but 97 patients’ prognosis were unknown. B.1 is the most common variant strain at the first infection. B.1.1.7, B.1.128 and B.1.351 were the most common variant strains at reinfection. Thirty-three patients were infected by different strains and 9 patients were reported as being infected with the same strain.ConclusionsOur research shows that it is possible for rehabilitated patients to be reinfected by SARS-COV-2. To date, the causes and risk factors of COVID-19 reinfection are not fully understood. For patients with reinfection, the diagnosis and management should be consistent with the treatment of the first infection. The public, including rehabilitated patients, should be fully vaccinated, wear masks in public places, and pay attention to maintaining social distance to avoid reinfection with the virus.
Fungal and viral entomopathogens as a combined strategy for the biological control of fall armyworm larvae in maize
Authors: Gómez-Valderrama Juliana , Cuartas-Otálora Paola , Espinel-Correal Carlos , Barrera-Cubillos Gloria , Villamizar-Rivero Laura 
Published: April 2022

AbstractBackgroundThe fall armywormSpodoptera frugiperdais one of the major pests in maize crops, causing important production losses. The pest has rapidly spread worldwide, generating an urgent need to develop efficient and sustainable strategies for its control. In this work, the potential of integrating nucleopolyhedrovirus- (NPV) and the fungusMetarhizium rileyito controlS. frugiperdalarvae was evaluated under laboratory, greenhouse, and field conditions.MethodsThe mortality ofS. frugiperdalarvae was evaluated after the application of NPV andM. rileyialone or in combination using three concentrations (high, medium and low) under laboratory conditions. Then, two greenhouse trials using maize plants were carried out to evaluate the effect of individual or combined applications of NPV andM. rileyionS. frugiperdamortality (first trial) and fresh damage (second trial). Finally, a trial under field conditions was conducted to evaluate the performance of the treatment selected in the greenhouse assay.ResultsThe combined use of NPV:M. rileyiapplied simultaneously showed an additive effect in laboratory, causing higher larval mortality than the biocontrol agents used separately. This effect was evident in the mixtures using the concentration levels high:medium, medium:medium, and medium:high. Under greenhouse conditions, the use of a 50:50 ratio of the two entomopathogens also caused higher larval mortality and a significantly reduced insect damage to plants. Finally, under field conditions, the individual or sequential application of NPV andM. rileyiusing 100% of their recommended doses, and the simultaneous application of both entomopathogens at 50% of their recommended doses, significantly reduced the recent foliar damage to levels under the threshold for economic losses (30% fresh damage) while the damage reached 43% when control measures were not used.ConclusionThe combined application of NPV andM. rileyi(two biocontrol agents with different mode of action) demonstrated an additive effect that allows to reduce to half their recommended application doses. In this context, the integration of both entomopathogens is a promising strategy to manageS. frugiperda,contributing to improve the economic feasibility of biological control tools for the sustainable fall armyworm management.
Clinical Outcomes of Patients With B-Cell Non-Hodgkin Lymphoma in Real-World Settings: Findings From the Hemato-Oncology Latin America Observational Registry Study
Authors: Pavlovsky Miguel , Cubero Daniel , Agreda-Vásquez Gladys Patricia , Enrico Alicia , Mela-Osorio Maria J. , San Sebastián Jorge Armenta , Fogliatto Laura , Ovilla Roberto , Avendano Oscar , Machnicki Gerardo , Barreyro Paula , Trufelli Damila , Villanova Pamella 
Published: April 2022

PURPOSE Real-world evidence on non-Hodgkin lymphoma (NHL) management in Latin America is currently lacking. The objective of this study was to describe treatment characteristics and outcomes of NHL in Latin America. METHODS A total of 2,967 patients with NHL with aggressive and indolent subtypes, including diffuse large B-cell lymphoma (DLBCL), follicular lymphoma (FL), mantle-cell lymphoma (MCL), and mucosa-associated lymphoid tissue (MALT) lymphoma, with incident or prevalent diagnosis between 2006 and 2015, were retrospectively identified using clinical charts registered in the Hemato-Oncology Latin America Observational Registry. Associations between treatment regimen and age at diagnosis with clinical outcomes within each subtype were estimated using Cox proportional hazard regression. RESULTS Most patients with NHL received 1L chemoimmunotherapy, most commonly cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) with/without rituximab. Five-year survival rates were higher for MALT lymphoma (90.8%) and FL (87.6%) versus DLBCL (69.0%) and MCL (57.1%), with variations between countries. The median overall survival from first relapse for patients with DLBCL was 6.6 years, with lower risk of death for those diagnosed at age < 65 years (hazard ratio = 0.732; P = .0161). Patients achieved a longer median progression-free survival with 1L rituximab-CHOP (R-CHOP) versus CHOP or rituximab, cyclophosphamide, vincristine, and prednisone (RCVP) (7.7 v 3.0 or 1.8 years, respectively). Use of regimens other than R-CHOP was associated with a higher risk of death/progression for patients with DLBCL (rituximab, ifosfamide, carboplatin, and etoposide/ifosfamide, carboplatin, and etoposide) and FL (CHOP). There was no relationship between treatment prescribed and age at diagnosis with outcomes from first/second relapse in DLBCL and FL. CONCLUSION Differences in treatment outcomes between NHL subtypes were observed, reflecting variations in NHL management and barriers to treatment access in Latin America. These data provide necessary evidence to understand NHL management in this region and highlight the need to improve treatment outcomes for these patients.
The Effect of Endogenous Cushing Syndrome on All-cause and Cause-specific Mortality
Authors: Limumpornpetch Padiporn , Morgan Ann W , Tiganescu Ana , Baxter Paul D , Nyawira Nyaga Victoria , Pujades-Rodriguez Mar , Stewart Paul M 
Published: April 2022

Abstract

Objective
We aimed to perform a systematic review and meta-analysis of all-cause and cause-specific mortality of patients with benign endogenous Cushing syndrome (CS).

Methods
The protocol was registered in PROSPERO (CRD42017067530). PubMed, EMBASE, CINHAL, Web of Science, and Cochrane Central searches were undertaken from inception to January 2021. Outcomes were the standardized mortality ratio (SMR), proportion, and cause of deaths. The I2 test, subgroup analysis, and meta-regression were used to assess heterogeneity across studies.

Results
SMR was reported in 14 articles including 3691 patients (13 Cushing disease [CD] and 7 adrenal CS [ACS] cohorts). Overall SMR was 3.0 (95% CI, 2.3-3.9; I2 = 80.5%) for all CS, 2.8 (95% CI, 2.1-3.7; I2 = 81.2%) for CD and 3.3 (95% CI, 0.5-6.6; I2 = 77.9%) for ACS. Proportion of deaths, reported in 87 articles including 19 181 CS patients (53 CD, 24 ACS, and 20 combined CS cohorts), was 0.05 (95% CI, 0.03-0.06) for all CS subtypes with meta-regression analysis revealing no differences between CS subtypes (P = .052). The proportion of deaths was 0.1 (10%) in articles published before 2000 and 0.03 (3%) in 2000 until the last search for CS (P &lt; .001), CD (P &lt; .001), and ACS (P = .01). The causes of death were atherosclerotic diseases and thromboembolism (43.4%), infection (12.7%), malignancy (10.6%), active disease (3.5%), adrenal insufficiency (3.0%), and suicide (2.2%). Despite improved outcomes in recent years, increased mortality from CS persists. The causes of death highlight the need to prevent and manage comorbidities in addition to treating hypercortisolism.
A Novel Approach to Microvascular Decompression for Hemifacial Spasm: Method Description and Associated Outcomes
Authors: Nagahiro Shinji , Mizobuchi Yoshifumi , Nakajima Kohei , Takagi Yasushi 
Published: April 2022

BACKGROUND:
Microvascular decompression (MVD) is the only potential cure for hemifacial spasm (HFS). However, traditional techniques such as the interposition method may have limited effect in some cases. Alternative techniques have been proposed; however, they can be more complex or difficult to perform than the standard approach.

OBJECTIVE:
To describe a safe decompression technique—the “shelter method”—which involves creating a shelter-like space around the facial nerve root exit zone and present associated outcomes.

METHODS:
Medical records and intraoperative findings of 92 patients with HFS who underwent MVD using the shelter method between April 1997 and March 2017 were retrospectively reviewed. As a historical control group, we included 53 patients who had undergone MVD by the traditional interposition method before March 1989. The patients were divided into 3 subgroups according to the arteries involved and degree or direction of arterial compression to the seventh nerve. Patient outcomes were assessed as excellent, good, fair, and poor according to the MVD scoring system of the Japan Society for MVD Surgery.

RESULTS:
In the shelter method group, complete disappearance of HFS was achieved in 87 patients (94.6%). The curative rate of the shelter method group was significantly higher than that of the interposition method group. The overall complication rates were significantly lower in the shelter method group than in the interposition method group.

CONCLUSION:
Our findings indicate high curative and low complication rates of the shelter method, suggesting that it helps treat HFS caused by various types of arterial compression.
Endoscope-Assisted Retroperitoneal Prepsoas Approach to Lumbar Intervertebral Disk Decompression. Technical Note
Authors: Mao Gordon , Pennington Zach , Liu Ann , Theodore Nicholas 
Published: April 2022

BACKGROUND:
Increasingly there is an impetus on the part of surgeons to find more minimally invasive approaches to treat spinal pathologies. Retroperitoneal prepsoas and transpsoas approaches to the lumbar spine are one such example gaining increased attention. Endoscope-assisted approaches may help further reduce soft tissue dissection.

OBJECTIVE:
To describe an endoscope-assisted lateral retroperitoneal prepsoas approach for lumbar diskectomy.

METHODS:
Two fresh-frozen thoracolumbar cadaveric specimens were obtained and placed in the right lateral decubitus position. Using a left-sided, retroperitoneal prepsoas approach to the lumbar spine and under endoscopic visualization, diskectomies were performed at the L2/3, L3/4, L4/5, and L5/S1 intervertebral spaces. Qualitative assessment of the extent of central and contralateral foraminal decompression was performed.

RESULTS:
The endoscope was found to provide effective visualization at all disk spaces and combined with the anterior retroperitoneal prepsoas approach allowed for effective decompression of all explored disk spaces. Both operators noted difficulty obtaining visualization of the ipsilateral foramen, but adequate central and contralateral foraminal decompression was achievable for central, paracentral, and contralateral far lateral disk protrusions.

CONCLUSION:
Endoscope assistance may improve visualization of the lumbar intervertebral disk spaces during retroperitoneal prepsoas approaches and thereby help to expand the surgical indication for anterior and oblique lumbar interbody fusion.