bluuebunny/crossref_metadata_2025_split huggingface dataset:
Upaya Pencegahan Stunting di Masa Pandemi Covid-19 Melalui Edukasi 2P (Pemenuhan Gizi Seimbang dan Pemberian Madu)
Authors: Hapzah Hapzah , Yudianti Yudianti , Saeni Rahmat Haji , Nurbaya Nurbaya 
Published: September 2022

Based on the data of SSGI 2021, the prevalence of stunting among under-five children in West Sulawesi is still quite high, namely 40.38%. Disturbances in the food and health systems caused by the Covid-19 pandemic have the potential to further exacerbate nutritional problems among children. One form of social support to the community is to maximize family resources through increasing knowledge related to preventing stunting problems during the Covid-19 pandemic. This community service activity aimed to provide 2P education, namely the provision of balanced nutrition and the Provision of honey. Educational materials are provided in the form of video slides sent via WhatsApp Group. The main targets were 15 participants that consist of cadres and mothers of under five children in the working area of ​​the Tinambung Health Center. Evaluation was carried out in the form of questions and answers and discussions with participants. Health workers need to be more innovative in promoting health and nutrition during the pandemic, such as regularly spreading nutrition messages through WhatsApp messages.

ABSTRAK
Berdasarkan hasil SSGI 2021 menunjukkan bahwa prevalensi balita stunting di Sulawesi Barat masih cukup tinggi yaitu 33,8%. Gangguan pada sistem pangan dan kesehatan yang diakibatkan oleh pandemi Covid-19 berpotensi semakin memperburuk masalah gizi balita. Salah satu bentuk dukungan sosial kepada masyarakat adalah dengan memaksimalkan sumber daya keluarga melalui peningkatan pengetahuan terkait pencegahan masalah stunting di masa pandemi Covid-19. Kegiatan pengabdian masyarakat ini bertujuan memberikan edukasi 2P yaitu pemenuhan gizi seimbang dan pemberian madu. Materi edukasi diberikan dalam bentuk video slides melalui WhatsApp Group. Sasaran utama kegiatan ini adalah 15 peserta yang terdiri dari kader dan ibu balita yang ada di wilayah kerja Puskesmas Tinambung. Evaluasi dilakukan dalam bentuk tanya jawab dan diskusi dengan peserta. Petugas kesehatan perlu lebih inovatif dalam melakukan promosi kesehatan dan gizi selama masa pandemi seperti rutin menyebarkan pesan gizi melalui pesan WhatsApp.
Fenomena TOFI (thin-outside-fat-inside) pada Pengunjung Mobil Layanan Konsultasi Kesehatan dan Keluarga di Kota Bogor
Authors: Navratilova Hana Fitria , Kuswidiarani Sekar 
Published: September 2022

Mobile health and family consulting services aims to provide public health-related services for free and as a data collection tool to formulate policies related to efforts to improve public health. Service activities were carried out at various locations in Bogor City by collecting data in the form of age, weight, height, percent body fat, and visceral fat. Data collected in the period of March 2015 to March 2020 (n = 3,482) showed that almost half of subjects with normal nutritional status had excess adiposity. Men were found to have higher visceral fat than women at normal nutritional status. Excess adiposity in normal nutritional status is associated with the incidence of metabolic syndrome. Therefore, the results of examination of body composition are needed as the basis for the formulation of a metabolic syndrome prevention program.

ABSTRAK
Mobil layanan konsultasi kesehatan dan keluarga bertujuan untuk memberikan pelayanan terkait kesehatan masyarakat secara gratis serta sebagai alat pengumpulan data untuk merumuskan kebijakan terkait upaya peningkatan kesehatan masyarakat. Kegiatan layanan dilakukan pada berbagai lokasi di Kota Bogor dengan mengumpulkan data berupa usia, berat badan, tinggi badan, persen lemak tubuh, dan lemak visceral. Data yang dikumpulkan pada periode Maret 2015 hingga Maret 2020 (n=3,482) menunjukkan bahwa hampir separuh subjek dengan status gizi normal memiliki adipositas berlebih. Pria ditemukan memiliki lemak visceral lebih tinggi daripada Wanita pada status gizi normal. Kejadian adipositas berlebih pada status gizi normal dikaitkan dengan kejadian sindrom metabolik. Oleh karena itu, diperlukan hasil pemeriksaan komposisi tubuh sebagai dasar perumusan program pencegahan sindrom metabolik.
Edukasi Pijat Laktasi dan Endhoprin pada Ibu Menyusui dalam Situasi Pandemi Covid-19
Authors: Ningsih Dewi Andariya , Sari Yuda Muhara , Kholifah Umi Nur 
Published: September 2022

Exclusive breastfeeding is the gold standard for infant feeding in the first six months. In Indonesia, breastfeeding has become a social norm among women. There are many factors that influence exclusive breastfeeding. One of the ways to facilitate the release of breast milk is by lactation massage therapy and endhoprin. This massage education activity was appointed as a community service activity. The purpose of this activity was to provide information to nursing mothers as references to massage methods to promote breast milk. It was recommended for breastfeeding mothers and to be carried out in September 2021. The implementation method was door to door due to the pandemic situation with complete self-protection. The result was 68% of all breastfeeding mothers can demonstrate well therefore that it can be concluded that this community service activity is running smoothly.

ABSTRAK
Pemberian ASI eksklusif merupakan standar emas pemberian makanan bayi pada enam bulan pertama. Di Indonesia, praktik menyusui sudah menjadi norma sosial di kalangan perempuan. Banyak faktor yang memengaruhi pemberian ASI eksklusif salah satu cara untuk memperlancar pengeluaran ASI dengan terapi pijat laktasi dan endhoprin. Kegiatan edukasi pijat inilah yang diangkat menjadi suatu kegiatan pengabdian kepada masyarakat. Tujuan kegiatan ini untuk memberikan informasi kepada ibu menyusui referensi metode pijat untuk melancarkan ASI. Sarannya para ibu menyusui dan dilaksanakan di bulan September 2021. Metode pelaksanaan dengan door to door karena situasi pandemi dengan perlindungan diri lengkap. Hasilnya 68% dari seluruh ibu menyusui dapat melakukan demonstrasi dengan baik sehingga dapat disimpulkan kegiatan pengabdian masyarakat ini berjalan lancar.
Skrining Anemia dan Pelatihan Pembuatan Susu Kedelai (Soymilk) sebagai Upaya Meningkatkan Kadar Hemoglobin pada Lansia
Authors: Kuncara Rachmad Bayu , Qomariyah Nurul , Afrianti Dina 
Published: September 2022

Anemia is a condition of low levels of erythrocytes in the blood which is characterized by decreased levels of hemoglobin and is most often experienced by the elderly. Soy milk is an important alternative for human nutrition and is suitable for iron fortification to reduce anemia. The purpose of this community service activity is for early detection of anemia in the elderly and nutritional fulfillment in the elderly to prevent anemia. The method used is the lecture and discussion method. The number of participants was 30 people and was held in Bangetayu Wetan Village RT 05 RW 05, Genuk District, Semarang City, Central Java Province. The results of this activity were 30 residents who were checked for hemoglobin levels with the results that 28 residents had hemoglobin levels >12 g/dl and 2 residents had hemoglobin levels <12 g/dl. In the soy milk training activity, more than 70 percent of the residents already understand the procedure for making soy milk.
ABSTRAK
Anemia adalah suatu keadaan rendahnya kadar eritrosit di dalam darah yang ditandai dengan menurunnya kadar hemoglobin dan paling sering dialami oleh lansia. Susu kedelai merupakan alternatif penting untuk nutrisi manusia dan cocok untuk fortifikasi zat besi untuk mengurangi anemia. Tujuan kegiatan pengabdian masyarakat ini adalah untuk deteksi dini adanya anemia pada lansia dan pemenuhan nutrisi pada lansia untuk mencegah anemia. Metode yang digunakan adalah metode ceramah dan diskusi. Jumlah peserta sebanyak 30 orang dan dilaksanakan di Desa Bangetayu Wetan RT 05 RW 05, Kecamatan Genuk, Kota Semarang, Provinsi Jawa Tengah. Hasil kegiatan ini sebanyak 30 warga yang di periksa kadar hemoglobin dengan hasil 28 warga kadar hemoglobinnya >12 gr/dl dan 2 warga kadar hemoglobinya <12 gr/dl. Pada kegiatan Pelatihan susu kedelai lebih 70 persen warga sudah memahami tata cara pembuatan susu kedelai.
Pediatric eosinophilic esophagitis outcomes vary with co-morbid eczema and pollen food syndrome
Authors: Sessions Julia , Purington Natasha , Wang Yiwen , McGhee Sean , Sindher Sayantani , Goyal Alka , Khavari Nasim 
Published: September 2022

BackgroundEosinophilic esophagitis (EoE) is a chronic immune-mediated inflammatory disease characterized by eosinophil inflammation of the esophagus. It has been described as a component of the Allergic March and is often seen with other atopic diseases. Some atopic diseases, including asthma, are known to be heterogenous with endotypes that guide treatment. Similarly, we propose that EoE is a heterogenous disease with varying phenotypes and endotypes that might impact response to therapy.MethodsA single-center retrospective review of pediatric patients ≤18 years of age diagnosed with EoE was conducted. All gastrointestinal clinic visits and esophagogastroduodenoscopies (EGD) from disease presentation through the first three years after diagnosis were reviewed. Histologic remission rate and therapies utilized [proton pump inhibitor (PPI), topical steroid, dietary elimination] were assessed.ResultsOne hundred and thirty-seven patients were included, 80% of whom had at least one concurrent atopic condition at diagnosis, with food allergies being the most common (57%) followed by eczema (34%), and asthma (29%). The remission rate of the overall cohort was 65%, and by concurrent allergy, comorbid pollen food syndrome and eczema had the highest remission rates at 100% and 81%, respectively followed by asthma (62%), food allergies (62%), seasonal allergic rhinitis (60%), and history of anaphylaxis (56%). Kaplan-Meier curves for each atopic condition show that patients with eczema and pollen food syndrome achieve histologic remission faster than those without. All treatment modalities were more successful in patients with eczema than those without, and PPI was most effective treatment at inducing remission.ConclusionsIn a real-world pediatric cohort, 80% of patients with EoE had an underlying atopic condition. Patients with eczema and pollen food syndrome had a swifter response and were more likely to achieve histologic remission than patients with other atopic conditions. This study suggests that EoE, like other allergic diseases, may have heterogenous phenotypes that could affect response to treatment. There is currently a knowledge gap in classifying EoE based on endotypes and phenotypes at diagnosis and correlating responses to various treatment modalities.
Histamine activates an intracellular Ca2+ signal in normal human lung fibroblast WI-38 cells
Authors: Berra-Romani Roberto , Vargaz-Guadarrama Ajelet , Sánchez-Gómez Josué , Coyotl-Santiago Nayeli , Hernández-Arambide Efraín , Avelino-Cruz José Everardo , García-Carrasco Mario , Savio Monica , Pellavio Giorgia , Laforenza Umberto , Lagunas-Martínez Alfredo , Moccia Francesco 
Published: September 2022

Histamine is an inflammatory mediator that can be released from mast cells to induce airway remodeling and cause persistent airflow limitation in asthma. In addition to stimulating airway smooth muscle cell constriction and hyperplasia, histamine promotes pulmonary remodeling by inducing fibroblast proliferation, contraction, and migration. It has long been known that histamine receptor 1 (H1R) mediates the effects of histamine on human pulmonary fibroblasts through an increase in intracellular Ca2+concentration ([Ca2+]i), but the underlying signaling mechanisms are still unknown. Herein, we exploited single-cell Ca2+imaging to assess the signal transduction pathways whereby histamine generates intracellular Ca2+signals in the human fetal lung fibroblast cell line, WI-38. WI-38 fibroblasts were loaded with the Ca2+-sensitive fluorophore, FURA-2/AM, and challenged with histamine in the absence and presence of specific pharmacological inhibitors to dissect the Ca2+release/entry pathways responsible for the onset of the Ca2+response. Histamine elicited complex intracellular Ca2+signatures in WI-38 fibroblasts throughout a concentration range spanning between 1 µM and 1 mM. In accord, the Ca2+response to histamine adopted four main temporal patterns, which were, respectively, termed peak, peak-oscillations, peak-plateau-oscillations, and peak-plateau. Histamine-evoked intracellular Ca2+signals were abolished by pyrilamine, which selectively blocks H1R, and significantly reduced by ranitidine, which selectively inhibits H2R. Conversely, the pharmacological blockade of H3R and H4R did not affect the complex increase in [Ca2+]ievoked by histamine in WI-38 fibroblasts. In agreement with these findings, histamine-induced intracellular Ca2+signals were initiated by intracellular Ca2+release from the endoplasmic reticulum through inositol-1,4,5-trisphosphate (InsP3) receptors (InsP3R) and sustained by store-operated Ca2+channels (SOCs). Conversely, L-type voltage-operated Ca2+channels did not support histamine-induced extracellular Ca2+entry. A preliminary transcriptomic analysis confirmed that WI-38 human lung fibroblasts express all the three InsP3R isoforms as well as STIM2 and Orai3, which represent the molecular components of SOCs. The pharmacological blockade of InsP3and SOC, therefore, could represent an alternative strategy to prevent the pernicious effects of histamine on lung fibroblasts in asthmatic patients.
Development and validation of a machine learned algorithm to IDENTIFY functionally significant coronary artery disease
Authors: Stuckey Thomas , Meine Frederick , McMinn Thomas , Depta Jeremiah P. , Bennett Brett , McGarry Thomas , Carroll William , Suh David , Steuter John A. , Roberts Michael , Gillins Horace R. , Lange Emmanuel , Fathieh Farhad , Burton Timothy , Khosousi Ali , Shadforth Ian , Sanders William E. , Rabbat Mark G. 
Published: September 2022

IntroductionMultiple trials have demonstrated broad performance ranges for tests attempting to detect coronary artery disease. The most common test, SPECT, requires capital-intensive equipment, the use of radionuclides, induction of stress, and time off work and/or travel. Presented here are the development and clinical validation of an office-based machine learned algorithm to identify functionally significant coronary artery disease without radiation, expensive equipment or induced patient stress.Materials and methodsThe IDENTIFY trial (NCT03864081) is a prospective, multicenter, non-randomized, selectively blinded, repository study to collect acquired signals paired with subject meta-data, including outcomes, from subjects with symptoms of coronary artery disease. Time synchronized orthogonal voltage gradient and photoplethysmographic signals were collected for 230 seconds from recumbent subjects at rest within seven days of either left heart catheterization or coronary computed tomography angiography. Following machine learning on a proportion of these data (N = 2,522), a final algorithm was selected, along with a pre-specified cut point on the receiver operating characteristic curve for clinical validation. An unseen set of subject signals (N = 965) was used to validate the algorithm.ResultsAt the pre-specified cut point, the sensitivity for detecting functionally significant coronary artery disease was 0.73 (95% CI: 0.68–0.78), and the specificity was 0.68 (0.62–0.74). There exists a point on the receiver operating characteristic curve at which the negative predictive value is the same as coronary computed tomographic angiography, 0.99, assuming a disease incidence of 0.04, yielding sensitivity of 0.89 and specificity of 0.42. Selecting a point at which the positive predictive value is maximized, 0.12, yields sensitivity of 0.39 and specificity of 0.88.ConclusionThe performance of the machine learned algorithm presented here is comparable to common tertiary center testing for coronary artery disease. Employing multiple cut points on the receiver operating characteristic curve can yield the negative predictive value of coronary computed tomographic angiography and a positive predictive value approaching that of myocardial perfusion imaging. As such, a system employing this algorithm may address the need for a non-invasive, no radiation, no stress, front line test, and hence offer significant advantages to the patient, their physician, and healthcare system.
Application of a new ultrasound criterion for the diagnosis of polycystic ovary syndrome
Authors: Giménez-Peralta Iván , Lilue Mariela , Mendoza Nicolás , Tesarik Jan , Mazheika Marina 
Published: September 2022

ObjectiveTo define which ultrasound criteria could replace the classic Rotterdam criteria as the best indicator of the risk of developing endocrine–metabolic changes in women with polycystic ovary syndrome (PCOS).Materials and methodsThis multicenter cross-sectional study included 200 women with PCOS and one control group of 111 women without PCOS. The primary outcomes to be considered were follicular count, hirsutism, total testosterone levels, free androgen index (FAI), and insulin sensitivity (HOMA-IR), and the secondary outcome was the anti-Müllerian hormone (AMH) level.ResultsThe main finding in this study points toward a different ultrasound criterion—23 or more follicles of any size in at least one ovary, which is postulated as an alternative to the classic criterion described in the Rotterdam consensus. This criterion correlates better with the other two PCOS criteria and also identifies women at increased risk of hirsutism (Ferriman–Gallwey score: 6.08 ± 3.54 vs. 4.44 ± 3.75, p &lt; 0.0001), total testosterone levels (2.24 ± 0.298 vs. 1.42 ± 1.530, p = 0.0001), FAI (4.85 ± 0.83 vs. 2.12 ± 1.93, p &lt; 0.001), and insulin resistance (HOMA-IR: 1.74 ± 0.182 vs. 1.504 ± 0.230, p = 0.001) more accurately. Regarding AMH, large differences in their mean values were observed between the groups (7.07 vs. 4.846 ng/ml, p = 0.000). However, these differences depended on age.ConclusionThe ovarian ultrasound examination with 23 or more follicles of any size in any of the ovaries constitutes a powerful tool to accurately diagnose PCOS and to associate it with metabolic–endocrine processes such as hyperandrogenism and insulin resistance.
Risk of preterm birth for placenta previa or low-lying placenta and possible preventive interventions: A systematic review and meta-analysis
Authors: Jansen Charlotte H. J. R. , van Dijk Charlotte E. , Kleinrouweler C. Emily , Holzscherer Jacob J. , Smits Anouk C. , Limpens Jacqueline C. E. J. M. , Kazemier Brenda M. , van Leeuwen Elisabeth , Pajkrt Eva 
Published: September 2022

ObjectiveTo investigate the risk of preterm birth in women with a placenta previa or a low-lying placenta for different cut-offs of gestational age and to evaluate preventive interventions.Search and methodsMEDLINE, EMBASE, CENTRAL, Web of Science, WHO-ICTRP and clinicaltrials.gov were searched until December 2021. Randomized controlled trials, cohort studies and case-control studies assessing preterm birth in women with placenta previa or low-lying placenta with a placental edge within 2 cm of the internal os in the second or third trimester were eligible for inclusion. Pooled proportions and odds ratios for the risk of preterm birth before 37, 34, 32 and 28 weeks of gestation were calculated. Additionally, the results of the evaluation of preventive interventions for preterm birth in these women are described.ResultsIn total, 34 studies were included, 24 reporting on preterm birth and 9 on preventive interventions. The pooled proportions were 46% (95% CI [39 – 53%]), 17% (95% CI [11 – 25%]), 10% (95% CI [7 – 13%]) and 2% (95% CI [1 – 3%]), regarding preterm birth &lt;37, &lt;34, &lt;32 and &lt;28 weeks in women with placenta previa. For low-lying placentas the risk of preterm birth was 30% (95% CI [19 – 43%]) and 1% (95% CI [0 – 6%]) before 37 and 34 weeks, respectively. Women with a placenta previa were more likely to have a preterm birth compared to women with a low-lying placenta or women without a placenta previa for all gestational ages. The studies about preventive interventions all showed potential prolongation of pregnancy with the use of intramuscular progesterone, intramuscular progesterone + cerclage or pessary.ConclusionsBoth women with a placenta previa and a low-lying placenta have an increased risk of preterm birth. This increased risk is consistent across all severities of preterm birth between 28-37 weeks of gestation. Women with placenta previa have a higher risk of preterm birth than women with a low-lying placenta have. Cervical cerclage, pessary and intramuscular progesterone all might have benefit for both women with placenta previa and low-lying placenta, but data in this population are lacking and inconsistent, so that solid conclusions about their effectiveness cannot be drawn.Systematic review registrationPROSPERO https://www.crd.york.ac.uk/prospero/, identifier CRD42019123675.
Linc00996 is a favorable prognostic factor in LUAD: Results from bioinformatics analysis and experimental validation
Authors: Shen Zhenghai , Li Xin , Hu Zaoxiu , Yang Yanlong , Yang Zhenghong , Li Shanshan , Zhou Yongchun , Ma Jie , Li Hongsheng , Liu Xi , Cai Jingjing , Pu Lisa , Wang Xiaoxiong , Huang Yunchao 
Published: September 2022

Background: Linc00996 has been reported in a variety of malignant tumors, but its potential role and significance in lung adenocarcinoma (LUAD) are not fully understood. The authors investigated the expression and biological behavior of Linc00996 in LUAD and elucidated the function of its potential target genes.Materials and methods: The data of Linc00996 expression in cancers were derived from GEPIA. GEO and TCGA datasets were used to identify the differential expression of Linc00996 in LUAD and analyze the respective correlation between different expression levels and LUAD stage and survival prognosis. We further elucidated the potential biological processes and pathways involved with Linc00996 in LAUD by GSEA. ssGSEA was applied to explore the relationship between Linc00996 and immune activity. Finally, the clinical impact of Linc00996 was assessed in 61 patients with LUAD, and the biological functions of Linc00996 were determined by a series of experiments in vitro, such as CCK8, colony formation, migration, and invasion assays.Results: Compared with adjacent normal lung tissues, Linc00996 was significantly downregulated in LUAD, and its expression was negatively correlated with T stage, N stage, and pathological stage. An in vitro study suggested that enhanced Linc00996 expression could inhibit cell proliferation, clonal formation, migration, and invasion in LUAD cell lines. Via GSEA and ssGSEA, we observed that Linc00996 might be connected with immune infiltration in LUAD, and Linc00996 might inhibit tumorigenesis and metastasis by regulating antigen processing and presentation, JAK-STAT3, and cell adhesion molecular signaling pathways.Conclusion: Linc00996 is a novel tumor suppressor in LUAD and may suppress the tumorigenesis and metastasis of LUAD via the tumor-related signaling pathway, such as antigen processing and presentation, JAK-STAT3, and cell adhesion molecular signaling pathways.