bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association Between Psoriasis and Dementia: A Retrospective Cohort Study
Authors: Zingel Rebecca , Jacob Louis , Smith Lee , Konrad Marcel , Kostev Karel 
Published: November 2022

Background: To date, no large study has examined the relationship between psoriasis and dementia in Germany. Objective: The aim of this study was to assess the association between psoriasis and the risk of all-cause dementia in patients followed in general practices in Germany. Methods: This retrospective cohort study is based on longitudinal data from the IQVIATM Disease Analyzer database and included patients with an initial diagnosis of psoriasis between January 1995 and December 2014 in 1,173 general practices in Germany. Patients without psoriasis were matched individually (1:1) to psoriasis patients using propensity scores. The main outcome of the study was the cumulative incidence of dementia diagnoses within up to 15 years of the index date. Univariate Cox proportional regression models were used to assess the relationship between psoriasis or psoriatic arthritis and dementia. Results: The present study included 10,583 patients with a diagnosis of psoriasis and 10,583 controls without psoriasis. After 15 years of follow-up, 22.0% of the psoriasis patients and 19.1% ( p < 0.001) of the non-psoriasis patients developed dementia. The incidence rate of dementia in 1,000 person-years was 15.0 in psoriasis patients and 11.9 in the non-psoriasis cohort. Psoriasis was significantly associated with a dementia risk (HR: 1.24; 95% CI: (1.14–1.35); p < 0.001). The association was stronger in patients with PsA (HR: 1.35; 95% CI: (0.98–1.86)) but this was not significant ( p = 0.070). Conclusion: The present study found a positive association between psoriasis and all-cause dementia in patients in general practices in Germany.
Efficacy of Glucose Metabolism-Related Indexes on the Risk and Severity of Alzheimer’s Disease: A Meta-Analysis
Authors: Zhou Yujia , Dong Jingyi , Song Jingmei , Lvy Chaojie , Zhang Yuyan 
Published: November 2022

Background: Considering the strong correlation made between Alzheimer’s disease (AD) and the pathology of glucose metabolism disorder, we sought to analyze the effects of fasting blood glucose (FBG) level, fasting plasma insulin (FINS) level, and insulin resistance index (HOMA-IR) on the risk and severity of AD. Objective: Reveal the pathological relationship between AD and insulin resistance. Methods: We searched 5 databases from inception through April 4, 2022. Meta-regression was conducted to identify if there were significant differences between groups. Shapiro-Wilk test and the Q-Q diagram were applied to evaluate the normality of variables. A multiple logistic regression model was employed to explore the association between FBG, FINS, HOMA-IR, and Mini-Mental State Examination scale score (MMSE). Results: 47 qualified articles including 2,981 patients were enrolled in our study. FBG ( p < 0.001), FINS ( p < 0.001), and HOMA-IR ( p < 0.001) were higher in AD patients than in controls. HOMA-IR was negatively correlated with MMSE ( p = 0.001) and positively related to the sex ratio (male versus female) ( p < 0.05). HOMA-IR obeyed lognormal distribution ( p > 0.05), and the 95% bilateral boundary values were 0.73 and 10.67. FBG ( p = 0.479) was positively correlated to MMSE, while FINS ( p = 0.1657) was negatively correlated with MMSE. Conclusion: The increase in the levels of FBG, FINS, and HOMA-IR served as precise indicators of the risk of AD. HOMA-IR was found to be correlated to the increasing severity of AD, especially in male AD patients.
Pineapple Mealybug, Dysmicoccus brevipes (Cockerell) (Insecta: Hemiptera: Pseudococcidae)
Authors: Egelie Ashley A. , Gillett-Kaufman Jennifer L. 
Published: November 2022

This EDIS publication is an alternate version of a page published first on the Featured Creatures website. The Featured Creatures collection provides in-depth profiles of insects, nematodes, arachnids and other organisms relevant to Florida. These profiles are intended for the use of interested laypersons with some knowledge of biology as well as academic audiences. This 5-page fact sheet that discusses the pineapple mealybug was written by Ashley A. Egelie and Jennifer L. Gillett-Kaufman, and published by the UF Entomology and Nematology Department, October 2015.
EENY635/IN1106: Pineapple Mealybug, Dysmicoccus brevipes (Cockerell) (Insecta: Hemiptera: Pseudococcidae) (ufl.edu)
Lesser Wax Moth Achroia grisella Fabricius (Insecta: Lepidoptera: Pyralidae)
Authors: Egelie Ashley A. , Mortensen Ashley N. , Barber Lynn , Sullivan Jessica , Ellis James D. 
Published: November 2022

This EDIS publication is an alternate version of a page published first on the Featured Creatures website. The Featured Creatures collection provides in-depth profiles of insects, nematodes, arachnids and other organisms relevant to Florida. These profiles are intended for the use of interested laypersons with some knowledge of biology as well as academic audiences. This 4-page fact sheet that discusses the lesser wax moth was written by Ashley A. Egelie, Ashley N. Mortensen, Lynn Barber, Jessica Sullivan, and James D. Ellis, and published by the UF Entomology and Nematology Department, November 2015.
EENY637/IN1108: Lesser Wax Moth Achroia grisella Fabricius (Insecta: Lepidoptera: Pyralidae) (ufl.edu)
Paper Wasp, Red Wasp (Suggested Common Names) Polistes carolina (L.) (Insecta: Hymenoptera: Vespidae)
Authors: Paulus Lizzie , Lucky Andrea 
Published: November 2022

This EDIS publication is an alternate version of a page published first on the Featured Creatures website. The Featured Creatures collection provides in-depth profiles of insects, nematodes, arachnids and other organisms relevant to Florida. These profiles are intended for the use of interested laypersons with some knowledge of biology as well as academic audiences. This 3-page fact sheet that discusses the paper wasp was written by Lizzie Paulus and Andrea Lucky, and published by the UF Entomology and Nematology Department, November 2015.
EENY640/IN1112: Paper Wasp, Red Wasp (Suggested Common Names) Polistes carolina (L.) (Insecta: Hymenoptera: Vespidae) (ufl.edu)
A Dual Ka/Q-Band Reflectarray
Authors: Polenga S. V. , Erokhin A. A. , Ryazantsev R. O. , Poligina A. D. , Krylov R. M. , Litinskaya E. A. , Gafarov E. R. , Aleksandrin A. M. , Salomatov Yu. P. , Danilov I. Yu. 
Published: November 2022

Introduction. Duplex satellite communication is commonly arranged using two spaced frequency bands, with one band receiving and the other band transmitting signals to a satellite. The main task of a communications satellite antenna system consists in providing an identical coverage area across all involved frequency bands, which is often a challenging task for conventional parabolic reflector antennas. Reflectarrays allow an independent control of the reradiated wave phase in spaced frequency bands, which can be used to create efficient multi-band antenna systems for modern communication satellites.Aim. To develop a Ka/Q-frequency range phase-correcting element and to create on its basis a dual-band reflectarray for operation with orthogonal circular polarizations and identical gains in a given sector of angles in significantly spaced frequency ranges.Materials and methods. Numerical studies were carried out using the finite element analysis method. Radiation patterns were measured using the near field scanning method.Results. A single-layer dual-band phase-correcting reflectarray element was developed for operation with orthogonal circular polarizations with low losses and a weak dependence of the relative position of the elements on the phase characteristic. On the basis of the proposed element, a reflectarray consisting of 24 465 two-frequency elements was synthesized and manufactured. The developed prototype of a single-layer dual-band reflectarray demonstrated good characteristics, with the efficiency reaching 56 and 36 % in the Ka- and Q-frequency ranges, respectively, and an almost identical minimum gain in the ±0.75° angle sector.Conclusion. The research results confirm the potential of the developed reflectarray to successfully replace conventional parabolic reflectors installed both on modern communication satellites and as part of ground-based satellite terminals in the millimeter wavelength range.
A Method of Spatial Processing for a Railway Crossing Control Radar System
Authors: Kuzin A. A. , Miakinkov A. V. , Fomina K. S. , Shabalin S. A. 
Published: November 2022

Introduction. Railway crossing is a source of increased danger for vehicles and pedestrians. To increase the safety of traffic at railway crossings, radar systems based on antenna arrays (AA) can be used. The important requirements for radar at a railway crossing are a wide field of view (up to 90 degrees) and, at the same time, a high accuracy in determining coordinates. Therefore, an analysis of methods for constructing AAs and spatial processing for an automatic traffic control system at a railway crossing seems to be a relevant research task. Aim. Design of a method for constructing the topology of an AA and spatial processing of a radar system for monitoring traffic at a railway crossing, providing a wide field of view with a high accuracy in determining the coordinates of targets. Materials and methods. The considered method was developed based on the theory of space-time signal processing. The design of the analyzed AA topologies was carried out by the finite element method (FEM) and the finite differ-ence time domain method (FDTD) based on segments of a microstrip transmission line. Results. A method for constructing a filled transceiver antenna array and a beamforming algorithm, which provide high angular resolution and unambiguous measurement of the target's angular coordinates in a wide field of view with relatively low computational complexity, was developed. Mathematical and electrodynamic modeling of the designed AA topologies was performed. Adjusted values of the radiation patterns (RP) of the transmitting and receiving AA were obtained, which showed good agreement with the calculated values. The main design solutions regarding the construction of AA radar for a railway crossing control system are presented to provide a wide field of view when determining the coordinates of targets. Conclusion. It was shown that the width of the resulting RP can be reduced by several times compared to the width of the receiving RP when using two transmitting antennas located at the edges of the aperture. This approach is similar to that used in the MIMO technology, although requiring no coherence of transmission channels and use of a system of orthogonal signals. The findings determine the prospects of using the developed method.
Development of a Method for the Quantitative Determination of Genisten for the Certification of a Certified Reference Material
Authors: Zhigalina A. A. , Strelova O. Yu. , Grebenyuk A. N. 
Published: November 2022

Introduction. One of the priority directions in the development of modern pharmacy is the search for new highly effective pharmaceutical substances with a high spectrum of pharmacological action and low toxicity. As a result of studies conducted by a number of authors, positive results have been shown for the use of genistein for the prevention and treatment of cardiovascular diseases and osteoporosis in menopausal women. It exhibits hypocholesterolemic and antidiabetic effects, as well as radioprotective properties. A comparative evaluation of genistein from soybean seed cake [Glycine max (L.) Merr.] and synthesized by SPC "Pharmzashchita" and the department of chemical technology of medicinal substances, SPCPU was carried out. Studies of natural genistein by GC-MS showed the presence of an admixture of a related isoflavone, daidzein, in the sample. The synthesized genistein was assessed in terms of qualitative analysis.Aim. The aim of our study was to develop a method for the quantitative determination of genistein for its certification as a CRM.Materials and methods. The object of the study was 96 % genistein (abcr. Gute Chemie, Германия). Quantitative determination by non-aqueous titration was carried out on a laboratory pH meter F20 (METTLER TOLEDO, USA) in a reagent grade DMFA medium (JSC "EKOS-1", Russia). The HPLC study was carried out on an Agilent 1200 Series high-performance liquid chromatograph LC-20 Prominence (Shimadzu, Japan).Results and discussion. The method of non-aqueous titration in DMFA medium which recommended by the State Pharmacopoeia of the Russian Federation XIV edition, titrant 0.1 M sodium hydroxide solution, was used as the basis for the development of a method for the quantitative determination of genistein. The end point of the titration was set using thymol blue indicator. However, the difficulty in visual fixation by changing the color of the indicator was noted. It has been proposed to use a potentiometric end-point determination. For the quantitative determination of genistein in dietary supplements and drugs containing this substance a HPLC method was proposed.Conclusion. A method for non-aqueous titration of genistein with potentiometric end-point determination in DMFA medium has been developed. The integral curve is not very informative for a clear definition of the titration end point. It is recommended to use a differential curve. The validation evaluation of the obtained results showed that the method is trueness (RSD, % = 1.25), precision (RSD, % = 1.21) and intermediate precision (on the first day of RSD, % = 1.21, on the second day of RSD, % = 1.41).
Development and Validation of HPLC Method for Identification of Ramipril in Printed Tablets and Filaments
Authors: Tihonova V. V. , Terenteva O. A. , Gusev K. A. , Flisyuk E. V. , Maimistov D. N. 
Published: November 2022

Introduction. 3D printing has shown its usefulness as a drug manufacturing technology over the past decade. However, the lack of regulated methods for quality control of finished printed drugs imposes a limitation on the widespread use of 3D printing methods in pharmaceutical practice. Thus, the development of methods for the analysis of printed dosage forms is of interest in pharmaceutical development.Aim. To develop a specific method for the determination of ramipril in filaments and printlets by HPLC.Materials and methods. Substance: ramipril. Excipients: Kollidon® VA 64, Kollidon® CL-F, PEG-1500, sodium carbonate anhydrous, Poloxamer-188, sodium stearyl fumarate. Reagents: hydrochloric acid, acetonitrile for ultra-HPLC, sodium octanesulfonate for HPLC, orthophosphoric acid 85 %, sodium perchlorate analytical grade, triethylamine. Standard: ramipril USP (No 1598303).Results and discussion. A special HPLC method in accordance with an ion-pair reagent (sodium octanesulfonate) for the determination of ramipril in the composition of filaments and printets was proposed.Conclusion. The developed chromatographic method should be adapted for ramipril release determination. This method can be used to quantify ramipril in further studies.
Development and Validation of Eltrombopag Determination in Human Plasma Blood by HPLC-MS Method
Authors: AL-Dhuraibi А. М. , Kulikov A. L. , Pokrovskiy M. V. 
Published: November 2022

Introduction. "Eltrombopag" is a thrombopoietin receptor agonist (TPO-RA) that is approved for the treatment of immune thrombocytopenic purpura (ITP). According to the literature, very few analytical methods for determining eltrombopag in biological samples have been reported. To study the pharmacokinetics of new formulations of eltrombopag, a sensitive and specific method is required that allows one to accurately determine the concentration of eltrombopag in human blood plasma. Normally, HPLC methods should provide time, accuracy, and sensitivity as a result, it is necessary to develop fast or ultra-fast methods such as LC-MS/MS without any loss in sensitivity or separation efficiency.Aim. We aimed to develop and validate a method for the quantitative determination of eltrombopag levels in human plasma by using HPLC with mass spectrometric detection for performing the analytical part of pharmacokinetic studies.Materials and methods. Eltrombopag levels were determined in human plasma by HPLC with mass spectrometric detection. The samples were prepared using protein deposition.Results and discussion. The method was validated for selectivity, matrix effect, calibration curve, accuracy, precision, the limit of quantification, carry-over effect, and sample stability.Conclusion. The method for the determination of eltrombopag levels in human plasma has been developed and validated by HPLC-MS. The analytical range of eltrombopag levels in human plasma was 10–6750 ng/ml. This method could be used to determine eltrombopag levels in plasma for PK and BE studies.
Clinical Testing of a New Radiopharmaceutical [<sup>99m</sup>Тс]-Al<sub>2</sub>O<sub>3</sub> for the Diagnosis of Sentinel Lymph Nodes
Authors: Medvedeva А. A. , Chernov V. I. , Zelchan R. V. , Bragina O. D. , Rybina A. A. , Skuridin V. S. , Stasyuk E. S. , Chizhevskaya S. Yu. , Goldberg A. V. , Garbukov E. Yu. 
Published: November 2022

Introduction. In modern oncology, the identification of sentinel lymph nodes (SLN), the first nodes that stand on the way of malignant tumor metastasis, is of increasing interest. Detection of SLN followed by morphological examination allows personalizing the surgical intervention for early breast cancer, melanoma, head and neck tumors, neoplasms of the cervix and endometrium. Currently, there is an active development of specific radiopharmaceuticals for SLN imaging. Within the framework of the grant from the Federal Target Program "Pharma-2020", an original radiopharmaceutical using gamma aluminum oxide – [99mТс]-Al2O3 was developed. Preclinical studies have been demonstrated its effectiveness and safety. Pharmacokinetic studies of [99mTc]-Al2O3 showed that 24 hours after its subcutaneous administration, about 12 % of the administered dose is accumulated in the SLN, which gives possibility for its detection.Aim. To study the possibility of clinical [99mTc]-Al2O3 using for visualization of SLN in breast, larynx and laryngopharyngeal cancer.Materials and methods. The definition of SLN was carried out in 55 patients with breast cancer and 30 patients with malignant tumors of the larynx and laryngopharynx. The study included peritumoral radiopharmaceutical injection, single-photon emission computed tomography with qualitative and quantitative analysis of the images and radioguided surgery detection of lymph nodes with their subsequent morphological examination.Results and discussion. Clinical studies have shown that radionuclide imaging of SLN using [99mTc]-Al2O3 is characterized by high sensitivity in breast cancer, larynx and laryngopharyngeal cancer patients (94.5 and 90 %, respectively), due to the high-intensity accumulation of this radiopharmaceutical in the lymph nodes. The optimal time point for SPECT and radioguided examination is an interval of 18–20 hours after injection of [99mTc]-Al2O3, which allows visualizing the maximum possible number of lymph nodes with the most optimal level of radioactivity for their detection.Conclusion. Application of radionuclide imaging of SLN with the use of [99mTc]-Al2O3 as a radiopharmaceutical is useful in planning surgical treatment of patients with tumors of the breast, larynx and laryngopharynx to determine the extent of surgery.
Lycium: Prospects of Application in Pharmacy of Plant Raw Materials Containing Alkaloids, Flavonoids, Polysaccharides and Other Biologically Active Substances of the <i>Solanaceae</i> Family Plants (Review)
Authors: Tupa B. , Potanina O. G. , Uspenskaya E. V. 
Published: November 2022

Introduction. The review is dedicated to the scientific analysis of the composition, properties and features of the biological effects on the man's organism of the Lycium Fruit as a prospective plant raw material for the production of innovative drugs.Text. The most important aspects related to plant raw materials of various types of Lycium are considered, such as, the worldwide prevalence of plants and the unification of raw materials numerous synonymous names, the generalization of pharmacopoeia data, the qualitative and quantitative composition of Lycium components, their structural features, biological effects on vital body systems. The review also presents the problem of the absence of general pharmacopoeia monographs on Lycium raw materials in Russia, despite the cultivation of Lyceum ruthenicum M. plants in Russia. This fact opens up significant opportunities to develop the Russian regulatory document for Lycium, as a promising pharmaceutical raw material.Conclusion. The obtained results demonstrate the potential of introducing into pharmacy a new type of pharmaceutical raw material and a new finished products based on them, as well as predicting the biological activity of the substances of Lycium fruit and mechanisms of alkaloids, flavonoids, polysaccharides and Lycium carotenoids action.
Application of Solid Dispersion Technology to Obtain a Model of Injectable Dosage Form of Indolocarbazole Derivative
Authors: Kolpaksidi A. P. , Dmitrieva M. V. , Orlova O. L. , Ektova L. V. , Krasniuk I. I. 
Published: November 2022

Introduction. N. N. Blokhin National Medical Research Center of Oncology of the Ministry of Health of Russia synthesized an original derivative of indolocarbazole with the carbohydrate residue xylose, which has a pronounced cytotoxic and anti-angiogenic activity. The substance LCS-1269 is an amorphous powder that is almost insoluble in water, which causes difficulties in the development of an injectable dosage form (IDP). To solve this problem, a technological approach to obtain a solid dispersion (SD) of LCS-1269 has been proposed.Aim. To develop a model of IDP of the indolocarbazole derivative LCS-1269 based on SD.Materials and methods. We used a substance LCS-1269 synthesized in the Chemical Synthesis Laboratory of the N. N. Blokhin National Medical Research Center of Oncology. Emuxol 268, Kolliphor® P 188, Soluplus®, Lutrol® F68, Kollidon® 12 and Kollidon® 17, soybean phosphatidylcholine unsaturated S PC and saturated S PC-3 were investigated as carriers of the active substance. SD LCS-1269 was obtained by solvent removal: the active substance was dissolved in acetone, the carrier − in chloroform, the obtained solutions were mixed, transferred into a bottle and evaporated under vacuum (50 ± 5 mbar) in the desiccator at water bath temperature 65 ± 2 °С. To obtain aqueous solution of LCS-1269 dry mass was dissolved using different auxiliary substances or their mixtures: water for injection, ethanol 95 %, benzyl alcohol, Kollisolv® PEG 400, MONTANOX™ 80. To increase stability, the aqueous solution of LCS-1269 was lyophilized in an Edwards Minifast DO.2 freeze dryer.Results and discussion. Kollidon® 17 was chosen as the carrier material for the SD active substance. It was found that a clear solution of LCS-1269 with the concentration of the active substance 0.5 % was formed by dissolving the SD in ethanol 95 % and then gradually diluting the alcohol mixture with water for injection. In this case, the mass ratio of the components of the developed model IDF LCS : Kollidon® 17 : ethanol : water is 1 : 40 : 32 : 127. As a result of freeze-drying of the water-ethanol solution of LCS-1269 the IDF in the form of lyophilizate easily soluble in a 10 % solution of ethanol was obtained.Conclusion. An IDF model of the hydrophobic derivative of indolocarbazole LCS-1269 based on SD was developed and submitted for biological studies to evaluate its effectiveness.