bluuebunny/crossref_metadata_2025_split huggingface dataset:
Minimally Invasive Surgery Periodontal Therapy for the Treatment of Intrabony Periodontal Defects
Authors: Thamaraiselvan Murugan , Narayan Siddharth , Soundarajan Subasree 
Published: June 2022

Background:
Minimally invasive therapeutic approaches have become the standard of care for many medical procedures. Conventional periodontal surgical therapies involve extensive tissue reflection, resulting in increased morbidity which stands to reason out that Minimally invasive surgery (MIS) approach for periodontal therapy would result in less morbidity and better esthetics for the patient. Thus, the aim of this review is to assess the clinical efficacy of MIS periodontal therapy compared to conventional access flap surgery for the treatment of intrabony periodontal defects.

Materials and Methods:
An electronic and manual search was done to identify and collect studies evaluating MIS periodontal therapy for the treatment of intrabony periodontal defects in terms of periodontal probing depth (PPD) reduction, clinical attachment level (CAL) gain, and gingival recession (REC) with a minimum of 6 month follow-up published in English. Six studies which satisfied the inclusion criteria were included for the review and the data extracted.

Results:
The six included studies contributed to a total of 193 patients who underwent 93 MIS therapies for treating intrabony defects with at least a 6-month follow-up. Clinical evaluation showed a PPD reduction ranging from 3.55 ± 0.88 mm to 5.2 ± 1.6 mm, while CAL gain ranged from 2.82 ± 1.19 mm to 4.5 ± 1.1 mm, while the change in gingival margin level ranged from 0.06 mm to 0.5 mm. Only one study directly compared single flap approach (SFA) (a type of MIS) to double flap approach (papilla preservation flap) which reported PPD reduction and CAL gain to be better in SFA.

Conclusion:
Even though the above evidence compels us to believe that minimally invasive periodontal surgery is less invasive, less time consuming, and less morbid, the lack of enough studies directly comparing MIS with conventional access flap surgeries suggest that these conclusions are arbitrary. Thus, there is currently an absence of adequate evidence to substantiate the beneficial effect of minimally invasive periodontal surgical approach compared to a conventional access flap surgery for the treatment of intrabony periodontal defects.
Assessing the Antimicrobial Properties of Copper-Iodide Doped Adhesives in an In vitro Caries Model
Authors: Mennito Anthony S. , Schmidt Michael , Lane Andrew , Kelly Abigail , Sabatini Camila , Renne Walter , Evans Zachary 
Published: June 2022

Context:
Recurrent caries are the leading cause of composite resin failure.

Aims:
The purpose of this pilot study was to test the efficacy of a novel copper iodide (CuI) containing dental adhesive in an in vitro caries model.

Subjects and Methods:

Streptococcus mutans and Lactobacillus acidophilus were grown individually on the complex medium for 48 h at 37°C. The pH of the mixed medium was 7.0 initially and tested every 24 h. 40 extracted teeth were prepared with standardized cavity preparations and coated with control or experimental CuI adhesives and imaged using a micro-computed tomography (microCT). Four study groups were evaluated: (1) control (2) 0.5 μg/ml CuI (3) 1.0 μg/ml CuI, 4) 5.0 μg/ml CuI. After incubation, the teeth were re-imaged using the microCT. Utilizing AnalyzePro software the three-dimensional data sets were overlaid and demineralization was measured and statistics were run.

Statistics:
Stratified ANOVA models were run to determine if there were differences between the control and experimental adhesive groups. Similarly, pH and bacterial concentrations were evaluated to ensure the viability of polymicrobial specimen.

Results and Conclusions:
Significant differences were found between the control group and the 1.0 and 5.0 CuI adhesive groups. No differences in pH were noted between the groups. Overlaid changes in demineralization were recorded as volume loss. CuI adhesives with 5 mg/ml or higher have the potential to limit tooth demineralization after bacterial penetration of a dental restoration in an in vitro caries model. Further testing is needed.
Cryptorchidism in Dalhatu Araf Specialist Hospital, Lafia, Nigeria
Authors: Agbo Christian A. , Godwin Joseph T. , Muhammad Musa Y. 
Published: June 2022

Objective:
To determine the presentation, management, and outcome of cryptorchidism in Dalhatu Araf Specialist Hospital, Lafia, Nigeria.

Materials and Methods:
This is a retrospective study conducted at Dalhatu Araf Specialist Hospital, Lafia, Nigeria. Information of patients who presented with cryptorchidism to the hospital from January 2015 to January 2020 was retrieved from the folders and analysed.

Results:
A total of 37 patients were studied during the study period. Only three (8.1%) presented and had correction before/at the age of two. A majority of patients (91.9%) presented after the age of two; 78% of the testes were palpable. The condition was unilateral in 30 patients (81.1%) and bilateral in seven patients (18.9%). Laparoscopy was used in one (2.7%) patient. A majority (51.4%) of the testes were in the inguinal canal, 29.7% at the external ring, 13.5% at the internal ring, and 5.4% within the abdomen. Orchidopexy was performed for 41 undescended testes and orchidectomy for three atrophic testes. There was a good outcome in 93.2% of the surgical corrections. Scrotal haematoma developed following two orchidopexies and one (2.2%) testis retracted.

Conclusion:
Cryptorchidism is a common anomaly in urology. The correction of cryptorchidism at the appropriate age is indicated to optimise testicular function, potentially reduce and/or facilitate the diagnosis of testicular malignancy, provide cosmetic benefits, and prevent complications such as a clinical hernia or torsion. Education of parents, traditional birth attendants, midwives, and doctors in our environment is required to ensure earlier presentation and treatment.
Introducing innovative cellular therapies into the clinic: a 2-year retrospective experience of a chimeric antigen receptor T-cell programme at a single centre in Switzerland
Authors: Stolz Sebastian , Roncador Marco , Rösler Wiebke , Zenz Thorsten , Manz Markus G. , Müller Antonia M.S. , Widmer Corinne C. 
Published: June 2022

AIM OF THE STUDY: Chimeric antigen receptor T (CAR-T) cells are a powerful form of immune-cell therapy for patients with relapsed/refractory B-cell lymphoma and acute B lymphoblastic leukaemia. CAR-T cells have been commercially available in Switzerland since 2018. Because of the complexity and costs of this treatment it is critical to review patient outcomes in real-world settings, to examine whether the promising results from pivotal trials can be reproduced and to identify clinical parameters that determine their efficacy.
METHODS: Here we present results of a retrospective study analysing outcomes of patients treated with CAR-T cells in a single academic centre in Switzerland during the first two years after commercial approval (BASEC-No. 2020-02271). Cytokine release syndrome (CRS), immune-cell associated neurotoxicity syndrome (ICANS), responses to treatment, ancillary laboratory studies and administrative specifics of CAR-T treatment were examined and are discussed.
RESULTS: From October 2018 to August 2020 CAR-T cell therapy was evaluated in 34 patients, mostly with relapsed/refractory aggressive B-cell lymphoma (87% had refractory disease). Thirty-one patients underwent leukapheresis. Three of 31 patients (9.6%) died of rapid disease progression before the CAR-T cell product was delivered, two patients were enrolled into a clinical trial, three patients were not given CAR-T cells for other reasons. Ultimately, 23 patients were infused with a commercial CAR-T cell product and included in this analysis. Fourteen (61%) patients received bridging therapy while waiting for a median of 41 days (range 31–62) for delivery of the CAR-T cell product. Toxicity and severe side effects were rare (CRS >3 in 13%, ICANS > grade 3 in 10% of patients), manageable and resolved completely thereafter. The best overall response rate was 65%, with complete responses in 38% of lymphoma patients. At 12 months postinfusion, 61% of patients were alive and 35% progression free. With a median follow-up of 14 months, 13/23 (56%) patients were alive at the time of writing.
CONCLUSION: CAR-T cell therapy proved to be safe and manageable under adequate hospital conditions. Outcomes resemble results from pivotal trials. The majority of patients was heavily pretreated and refractory at the time of CAR-T cell infusion. Patient selection, time point of leukapheresis, bridging strategies and timing of CAR-T cell infusion may be critical to further improve outcomes.
Curtain of Glass – Textured by Stone
Authors: Engelmann Michael , Reuschle Klaus , Muscatello Salvatore , Sperandio Thomas 
Published: June 2022

The new World Trade Center site was rebuilt after 9/11 comprising seven mayor skyscrapers around the memorial site and the 9/11 museum. Between WTC 2 and WTC 3, Santiago Calatrava’s Oculus Station spans its wings in the NY air while finally, the complex is completed by the “The Ronald O. Perelman Performing Arts Center”. This building sets a one-in-a-kind visual appearance to the area. Its four-sided, 42 m tall, even facade is made from 4736 equal-sized insulated glass panes. More specifically, the architectural vision is to create a marble stone front covered with glass which results in a stone-glass laminate as a part of an insulated glass unit. The marble shows a distinguished white face with crisp black veining. Each of the four elevations of the building impresses with a perfect symmetry and veins touching at the vertical center line. So, the design team at Josef Gartner was challenged to set-up a logistics chain from quarry in Portugal where the stone panels were cut and catalogued to glass production of laminated glass in France and IGUs in Germany and assembly of curtain wall mega-panels at Gartner in Germany up to the site in Lower Manhattan. Our in-house logistics concept, customized for this project, guarantees that each individual piece of stone finds its correct and unique spot defined by the architect on the 7,000 m2 surface – a large-scale game of “Matching Pairs”. The steel base building provides a cantilevering roof that holds 128 hot-rolled steel mullions. Each 36 m in length with one intermediate lateral support only. This allows the visitor to experience a clear and unobstructed view along the transom-free facade elements that carry the translucent stone-wall. During the day, it appears white from the outside and shines with an amber-glow during the night when the interior space is illuminated. We show the use of a novel stone-glass product that is exposed to a variety of requirements. The logistics chain is described from quarry to site making sure that the architectural and economical demand is met along the whole process. Finally, the team connects all branches in facade design using stone, aluminum, glass and architectural exposed structural steel assembled in one landmark project.
Caregiver Coaching in Early Intervention: A Scoping Review
Authors: Seruya Francine M. , Feit Emily , Tirado Alexys , Ottomanelli Diana , Celio Melissa 
Published: June 2022

Abstract
Importance: Best practice guidelines and legal mandates have deemed parent engagement an essential component of early intervention (EI). Parent coaching is an intervention and a model of service delivery used in occupational therapy practice that is designed to integrate parents into the therapy session.
Objective: To examine the current definitions of coaching and the ways in which U.S. occupational therapy practitioners are using coaching models in EI.
Study Selection and Data Collection: We systematically searched 11 databases—CINAHL Complete, CINAHL with full text, Education Research Complete, ERIC, PsycARTICLES, PsycINFO, Teacher Reference Center, Academic Search Premier, Academic Search Complete, Socindex with full text, and Social Work Abstracts—for articles published from 2000 through 2020. A total of 178 articles were retrieved, and 60 underwent full-text review. The final review included 16 studies of varying designs in which occupational therapy was one of the interventions and in which various definitions of coaching and models were used.
Findings: The concepts inherent in coaching models were consistent across studies. There was little emphasis on the efficacy of coaching models as related to goal attainment.
Conclusions and Relevance: Coaching is a viable intervention in EI. Studies are needed to assess the efficacy of the parent coaching model in achieving child and family outcomes and the training needed to provide the intervention appropriately.
What This Article Adds: This scoping review explores existing research on coaching interventions and models used by occupational therapists in EI. Findings indicate that this is an area of opportunity because the model of parent coaching strongly aligns with the professional scope of occupational therapy practice.
Microstructure of practice activities for team and individual sports
Authors: Tan Angelina Li San , Low Jeffrey Fook Lee 
Published: June 2022

PurposeResearch on the microstructure of practice activities has reported equivocal findings. Limited sports have been included in systematic observations. Playing form activities have not been examined for individual sports. This study scrutinized the amount of time devoted to different activities during practice and refined the usability of playing form and training form for various sports.MethodsSystematic observations were conducted in an elite sports school. Youth athletes aged 16–20 years and coaches from 6 different sports (hurdling, archery, field hockey, netball, squash, volleyball) were involved. Practice activities were categorized as playing form, training form, and transition, and compared between sports.ResultsThe proportion of different activities conducted during practice varied for each sport and coach. Hurdlers employed the longest time on transition (43%), squash players utilized the majority of time on playing form (40%), whilst the archers and all 3 team sports athletes consumed most time on training form (51–83%). Representatives of 3 sports did not engage in any playing form activities.ConclusionsThis study showed that elite coaches are still applying traditional approaches in structuring practice activities. Coaches should employ playing form during practice sessions, but the definition needs to be adapted to encompass multiple sports.
LIÊN QUAN, TƯƠNG QUAN GIỮA NHỊP SINH HỌC HUYẾT ÁP VỚI MICROALBUMIN NIỆU Ở BỆNH NHÂN ĐÁI THÁO ĐƯỜNG TÝP II CÓ TĂNG HUYẾT ÁP
Authors: Trường Sinh Cao 
Published: June 2022

Mục đích: Xác định mối liên quan, tương quan giữa các thông số huyết áp lưu động 24 giờ với microalbumin niệu ở bệnh nhân đái tháo đường týp II có tăng huyết áp. Đối tượng và phương pháp: 31 bệnh nhân đái tháo đường týp II có tăng huyết áp, 19 nam, 12 nữ, tuổi trung bình 63,71 ±6,9 năm, đồng ý tham gia nghiên cứu. Tất cả bệnh nhân được đo huyết áp lâm sàng bằng huyết áp kế thủy ngân, sau đó được đo huyết áp lưu động 24 giờ (Ambulatory Blood Pressure Monitoring-ABPM) bằng máy Suntech Oscar 2, USA với khoảng cách đo 30 phút/lần vào ban ngày từ 6 AM đến 10 PM và 60 phút /lần vào ban đêm từ 10PM đến 6 AM hôm sau. Tất cả bệnh nhân được làm xét nghiệm microalbumin niệu cùng ngày với ABPM. Kết quả: Nồng độ trung bình albumin niệu ở nhóm không trũng huyết áp ban đêm cao hơn có ý nghĩa nhóm có trũng huyết áp ban đêm, nhóm quá tải HATT 24h ≥ 50% cao hơn có ý nghĩa nhóm qúa tải HATT 24h < 50%. Có mối tương quan nghịch có ý nghĩa giữa nồng độ albumin niệu và phần trăm giảm huyết áp tâm thu ban đêm với p <0,05, r = -0,367; Có mối tương quan nghịch có ý nghĩa giữa nồng độ albumin niệu và phần trăm giảm huyết áp tâm trương ban đêm với p < 0,05, r = -0,399. Kết luận: Có mối liên quan và tương quan giữa tình trạng không trũng huyết áp ban đêm và quá tải huyết áp với nồng độ microalbumin niệu ở bệnh nhân đái tháo đường týp II có tăng huyết áp.
Direct U-series dating of the Apidima C human remains
Authors:   DFG Center of Advanced Studies ", Harvati Katerina ,   Words, Bones, Genes, Tools,",   University of Tübingen, Grün Rainer , Duval Mathieu , Zhao Jian-xin , Karakostis Alexandros , Tourloukis Vangelis , Gorgoulis Vassilis , Kouloukoussa Mirsini ,   Senckenberg Centre for Human Evolution and Palaeoenvironments
Published: June 2022

The site of Apidima, in southern Greece, is one of the most important Paleolithic sites in Greece and southeast Europe. One of the caves belonging to this cave complex, Cave A, has yielded human fossil crania Apidima 1 and 2, showing the presence of an early Homo sapiens population followed by a Neanderthal one in the Middle Pleistocene. Less known are the human remains reportedly recovered from Cave C at Apidima. These include a number of isolated elements, but also a partial skeleton interpreted as a female burial, Apidima 3, proposed by Pitsios (e.g., Pitsios 1999) to be associated with Aurignacian lithics and to date to ca. 30 ka. In light of the rarity of the Upper Paleolithic in Greece, and the general scarcity of human remains associated with the Aurignacian, the remains from Apidima Cave C are potentially very significant in elucidating the arrival of the early Upper Paleolithic populations in Europe. Here we undertake direct Uranium-series dating of three human samples from Cave C, including the burial, to help clarify their chronology. Results suggest a minimum age of terminal Pleistocene for all three samples.
Dinamika Awal Aktivitas Nahdhlatul Ulama dalam Catatan Pers Masa Kolonial 1925 – 1942
Authors: Saehudin Akhmad 
Published: June 2022

Abstrak
Kebijakan Politik Islam di Hindia Belanda medorong para sarjana muslim mendirikan organisasi Islam, termasuk, Nahdhlatul Ulama, sebagai saluran aktivitasanya. Ini dilakukan untuk kebersamaan dan wahana persatuan. Dengan berorganisasi, maka dapat menciptakan gerak bersama untuk menghindari tuduhan melakukan aktivitas mencurigakan dalam hal keagamaan dari otoritas kolonial. Di sisi lain, peran pers dalam meliput kegiatan NU tergolong besar. Organisasi ini dianggap mempunyai modal politik dan kultural yang penting dalam dinamika Muslim di Hindia Belanda.
Artikel ini berupaya menyuguhkan sejumlah aktivitas NU yang direkam oleh surat kabar pada masa kolonial. Beberapa berita yang ditemukan cukup unik, karena meliput aktivitas perkumpulan ini sampai di tingkat daerah, seperti di Kediri dan Semarang. Pencarian informasi mengarah pada tiga aspek yang menjadi perhatian NU antara 1925 hingga 1942, yakni masalah Kongres Al-Islam, ritual keagamaan dan respon atas kebijakan sekolah liar.
Beberapa temuan mengarah pada sisi sejarah sosial dari kegiatan NU. Ini sekaligus menjadi catatan pinggir bagi historiografi terdahulu, yang lebih banyak menyorot NU dalam kaca mata sejarah politik. Berbekal pada metode penelitian sejarah, diperoleh suatu bahan telaah kronologis yang dekat dengan nuansa sejarah sosial.

Political Islam policy in the Dutch East Indies encouraged Muslim scholars to establish Islamic organizations, including, Nahdhlatul Ulama, as a channel for their activities. This is done for togetherness and a vehicle of unity. By organizing, it can create a common movement to avoid accusations of carrying out suspicious activities in religious matters from the colonial authorities. On the other hand, the role of the press in covering NU's activities is quite large. This organization is considered to have political and cultural capital that is important in the dynamics of Muslims in the Dutch East Indies.
This article attempts to present a number of NU activities recorded by newspapers during the colonial period. Some of the news found is quite unique, because it covers the activities of this association to the regional level, such as in Kediri and Semarang. The search for information led to three aspects of concern to the NU between 1925 and 1942, namely the issue of the Al-Islam Congress, religious rituals and the response to the wild school policy.
Some of the findings point to the social history side of NU's activities. This is also a marginal note for earlier historiography, which highlighted NU more in the lens of political history. Armed with historical research methods, a chronological study material is obtained that is close to the nuances of social history.
Warm and moist air intrusions into the winter Arctic: a Lagrangian view on the near-surface energy budgets
Authors: You Cheng , Tjernström Michael , Devasthale Abhay 
Published: June 2022

Abstract. In this study, warm and moist air intrusions (WaMAIs) over the
Arctic Ocean sectors of Barents Sea, Kara Sea, Laptev Sea, East Siberian Sea, Chukchi Sea, and
Beaufort Sea in 40 recent winters (from 1979 to 2018) are identified from
the ERA5 reanalysis using both Eulerian and Lagrangian views. The analysis shows
that WaMAIs, fueled by Arctic blocking, cause a relative surface warming
and hence a sea-ice reduction by exerting positive anomalies of net thermal
irradiances and turbulent fluxes on the surface. Over Arctic Ocean sectors
with land-locked sea ice in winter, such as Laptev Sea, East Siberian Sea, Chukchi Sea,
and Beaufort Sea, the total surface energy-budget is dominated by net thermal
irradiance. From a Lagrangian perspective, total water path (TWP) increases
linearly with the downstream distance from the sea-ice edge over the
completely ice-covered sectors, inducing almost linearly increasing net
thermal irradiance and total surface energy-budget. However, over the
Barents Sea, with an open ocean to the south, total net surface
energy-budget is dominated by the surface turbulent flux. With the energy in the warm-and-moist air continuously transported to the surface, net surface turbulent flux gradually decreases with distance, especially within the first 2∘ north of the ice edge, inducing a decreasing but still
positive total surface energy-budget. The boundary-layer energy-budget
patterns over the Barents Sea can be categorized into three classes:
radiation-dominated, turbulence-dominated, and turbulence-dominated with cold dome, comprising about 52 %, 40 %, and 8 % of all WaMAIs, respectively. Statistically, turbulence-dominated cases with or without cold dome occur
along with 1 order of magnitude larger large-scale subsidence than the
radiation-dominated cases. For the turbulence-dominated category, larger
turbulent fluxes are exerted to the surface, probably because of stronger
wind shear. In radiation-dominated WaMAIs, stratocumulus develops more
strongly and triggers intensive cloud-top radiative cooling and related
buoyant mixing that extends from cloud top to the surface, inducing a
thicker well-mixed layer under the cloud. With the existence of cold dome,
fewer liquid water clouds were formed, and less or even negative turbulent
fluxes could reach the surface.