bluuebunny/crossref_metadata_2025_split huggingface dataset:
Characteristics of ‘mega’ peer-reviewers
Authors: Rice Danielle B. , Pham Ba’ , Presseau Justin , Tricco Andrea C. , Moher David 
Published: February 2022

Abstract
Background
The demand for peer reviewers is often perceived as disproportionate to the supply and availability of reviewers. Considering characteristics associated with peer review behaviour can allow for the development of solutions to manage the growing demand for peer reviewers. The objective of this research was to compare characteristics among two groups of reviewers registered in Publons.

Methods
A descriptive cross-sectional study design was used to compare characteristics between (1) individuals completing at least 100 peer reviews (‘mega peer reviewers’) from January 2018 to December 2018 as and (2) a control group of peer reviewers completing between 1 and 18 peer reviews over the same time period. Data was provided by Publons, which offers a repository of peer reviewer activities in addition to tracking peer reviewer publications and research metrics. Mann Whitney tests and chi-square tests were conducted comparing characteristics (e.g., number of publications, number of citations, word count of peer review) of mega peer reviewers to the control group of reviewers.

Results
A total of 1596 peer reviewers had data provided by Publons. A total of 396 M peer reviewers and a random sample of 1200 control group reviewers were included. A greater proportion of mega peer reviews were male (74%) as compared to the control reviewers (58% male). Mega peer reviewers demonstrated a significantly greater average number of total publications, citations, receipt of Publons awards, and a higher average h index as compared to the control group of reviewers (all p < .001). We found no statistically significant differences in the number of words between the groups (p > .428).

Conclusions
Mega peer reviewers registered in the Publons database also had a higher number of publications and citations as compared to a control group of reviewers. Additional research that considers motivations associated with peer review behaviour should be conducted to help inform peer reviewing activity.
Coordination of dual setting overcurrent relays in microgrid with optimally determined relay characteristics for dual operating modes
Authors: Tiwari Raghvendra , Singh Ravindra Kumar , Choudhary Niraj Kumar 
Published: February 2022

AbstractFault current magnitude in a microgrid depends upon its mode of operation, namely, grid-connected mode or islanded mode. Depending on the type of fault in a given mode, separate protection schemes are generally employed. With the change in microgrid operating mode, the protection scheme needs to be modified which is uneconomical and time inefficient. In this paper, a novel optimal protection coordination scheme is proposed, one which enables a common optimal relay setting which is valid in both operating modes of the microgrid. In this context, a common optimal protection scheme is introduced for dual setting directional overcurrent relays (DOCRs) using a combination of various standard relay characteristics. Along with the two variables, i.e., time multiplier setting (TMS) and plug setting (PS) for conventional directional overcurrent relay, dual setting DOCRs are augmented with a third variable of relay characteristics identifier (RCI), which is responsible for selecting optimal relay characteristics from the standard relay characteristics according to the IEC-60255 standard. The relay coordination problem is formulated as a mixed-integer nonlinear programming (MINLP) problem, and the settings of relays are optimally determined using the genetic algorithm (GA) and the grey wolf optimization (GWO) algorithm. To validate the superiority of the proposed protection scheme, the distribution parts of the IEEE-14 and IEEE-30 bus benchmark systems are considered.
Cancer treatment regimens and their impact on the patient-reported outcome measures health-related quality of life and perceived cognitive function
Authors: Grusdat Niklas Paul , Stäuber Alexander , Tolkmitt Marion , Schnabel Jens , Schubotz Birgit , Wright Peter Richard , Heydenreich Marc , Zermann Dirk-Henrik , Schulz Henry 
Published: February 2022

AbstractBackground and purposeBreast cancer can be a significant challenge for those affected. Knowledge of physical function, social-emotional challenges, and perceived cognitive function based on the cancer treatment regimens may help to inform adequate support.MethodsFor this prospective observational pilot study, we collected data of seventy-nine women (mean age 54.6 ± 9.5 years) before (T0) and after (T1) initial breast cancer treatment. Functional Assessment of Cancer Therapy-Breast (FACT-B) and Functional Assessment of Cancer Therapy–Cognitive-Function (FACT-Cog) were used to collect data of four treatment subgroups: SCR = Surgery + Chemotherapy + Radiation Therapy; SC = Surgery + Chemotherapy; SR = Surgery + Radiation Therapy; S = Surgery. A mixed ANOVA and posthoc analysis (Tukey, Games-Howell) were used to detect interactions (group by time) and the main effect. A repeated-measures ANOVA displayed individual group differences (time).ResultsSignificant interaction showed more deterioration was experienced with SC and SCR than SR and S for FACT-B (p < 0.01) and FACT-Cog (p < 0.001). The longitudinal comparison between T0 and T1 indicated a significant group main effect on all subscales (p < 0.001) except for Emotional Well-Being. Significant reductions (p < 0.05) in FACT-B, (− 19%); FACT-Cog, (− 21%) with most pronounced effect in Physical Well-Being (− 30%), Functional Well-Being (− 20%), Breast Cancer Subscale (− 20%), Perceived Cognitive Impairments (− 18%) and Impact of Cognitive Impairments on Quality of Life (− 39%) were detected for SCR.ConclusionOur study showed that the extent of change in health-related quality of life (HRQoL) and perceived cognitive function (PCF) depends on the treatment regimen. Multidisciplinary support initiated early in breast cancer therapy is needed, especially for women undergoing combined cancer treatment. Routine assessment of patient-reported outcomes (PROs) in oncology practice may increase the transparency of patients’ perceived circumstances, leading to personalized and optimized acute and survivorship care.
Effect of waist circumference and body mass index on the level of spinal anesthesia
Authors: Günkaya Mustafa , Arar Cavidan , Mordeniz Cengiz , Baran Onur , Topçu Birol 
Published: February 2022

Abstract
Background
We aimed to determine the effects of waist circumference and body mass index on spinal anesthesia levels. In total, 120 surgical patients who were between 18 and 65 years old and in the American Society of Anesthesiologists’ (ASA) I–III risk groups enrolled in this study. Patients were classified into three groups, depending on their weight. After a spinal block, we noted the time needed for the sensory block to reach the T10 level, the maximum sensory block level, the time needed for the sensory block to reach the maximum sensory block level, the time needed before the start of the motor block, and the Bromage scale for each patient.

Results
We observed no significant demographic differences in age, gender, or ASA risk class between the groups; however, we found a statistically significant difference between the groups’ BMIs and waist circumferences. For the time needed for the spinal block to reach the T10 level, we observed a statistically significant difference between groups I, II, and III, and we also found a statistically significant difference between the groups’ comparing Bromage scales. Moreover, we found a statistically significant difference between the groups’ time needed (in minutes) for the block to reach the maximal upper dermatomal block level and, as BMIs and waist circumferences increased, the time needed to reach the maximal upper dermatomal block level. We also noted a statistically significant difference in waist circumference variability.

Conclusions
This study shows that body mass index and waist circumference can be used and interpreted as independent parameters reflecting the increasing incidence of obesity.
Numerical simulation of a complex moving rigid body under the impingement of a shock wave in 3D
Authors: Liu Shihao , Cheng Ziqiang , Jiang Yan , Lu Jianfang , Zhang Mengping , Zhang Shuhai 
Published: February 2022

AbstractIn this paper, we take a numerical simulation of a complex moving rigid body under the impingement of a shock wave in three-dimensional space. Both compressible inviscid fluid and viscous fluid are considered with suitable boundary conditions. We develop a high order numerical boundary treatment for the complex moving geometries based on finite difference methods on fixed Cartesian meshes. The method is an extension of the inverse Lax-Wendroff (ILW) procedure in our works (Cheng et al., Appl Math Mech (Engl Ed) 42: 841–854, 2021; Liu et al.) for 2D problems. Different from the 2D case, the local coordinate rotation in 3D required in the ILW procedure is not unique. We give a theoretical analysis to show that the boundary treatment is independent of the choice of the rotation, ensuring the method is feasible and valid. Both translation and rotation of the body are taken into account in this paper. In particular, we reformulate the material derivative for inviscid fluid on the moving boundary with no-penetration condition, which plays a key role in the proposed algorithm. Numerical simulations on the cylinder and sphere are given, demonstrating the good performance of our numerical boundary treatments.
Kinetic modelling of in situ treatment of petroleum hydrocarbon contaminated soil using bone char and NPK fertilizers
Authors: Okwonna Obumneme O. , Otaraku Ipeghan J. 
Published: February 2022

AbstractThis study investigates the effectiveness of bone char (organic) and inorganic nitrogen, phosphorous, and potassium (NPK) fertilizers as stimulants in the degradability of petroleum hydrocarbon contaminants on soil. The physicochemical properties of the hydrocarbon sludge were used to assess the effectiveness of this process over an 8-week period using 0.5–3.5 kg mass of each fertilizer at different experiments. A first order kinetic model was used to estimate the rate of degradation of the total hydrocarbon content (THC) and total organic carbon (TOC) contaminants and the half-life of the remediation process. The microbial population within the period was also determined. The p-value (p < 0.05) indicated that these fertilizers were effective in degrading these contaminants on the soil, because of the significant difference between the treated and the control soil samples. A direct relationship was observed between with the mass and performance of the fertilizers. With 3.5 kg mass of the fertilizers, rate constants of 0.018 and 0.019 d− 1 were obtained for the removal of the THC and TOC contaminants, respectively, using the bone char fertilizer, whereas NPK fertilizer gave rates of 0.03 and 0.023 d− 1 respectively. The performance of the NPK fertilizer is attributable to its nitrogen and phosphorous content. The model adequately described the process and showed the effectiveness of both fertilizers in the remediation process.
Phytochemical screening, antioxidant study and hematinic property of Mojeaga herbal remedy using animal model
Authors: Idu MacDonald , Alugeh Monday Ojeaga , Alugeh Micheal Ojeaga , Gabriel Benjamin Ogunma 
Published: February 2022

AbstractBackgroundPlants have been used as medicine since ancient time and contributed immensely to health care delivery system globally. The aim of this study was to evaluate the phytoconstituents, antioxidant and hematinic property of Mojeaga herbal remedy (Alchornea cordifolia, Sorghum bicolorandPennisetum glaucum) in animal model. Standard protocols were used to analyze the qualitative and quantitative phytochemical, gas chromatography mass spectrum (GC–MS), andin vitroantioxidant studies (1, 1-diphenyl-2-picrylhydrazyl) (DPPH), ferric reducing antioxidant power (FRAP) and total antioxidant capacity were also used to assess these plants. Ninety Wistar rats of both sexes were selected for this study. They were administered with 40 mg/kg phenylhydrazine hydrochloride to induce anemia for 5 days afterward treated with oral dose of 0.5, 1.0 and 2.0 ml/kg Mojeaga herbal remedy for 10 days. Hematological, CD4 and CD8, and histology of the blood and bone marrow were analyzed.ResultsThe phytochemical screening showed the presence of flavonoids, alkaloids, tannins, saponins, cardiac glycosides, terpenoids and phenol. Flavonoids and phenol were more in abundant (917 and 1445 mg/kg). The GC–MS analysis shows the presence of disulfide, dimethyl, 2-Methoxy-4-vinylphenol, 1-Dodecanol, 10-Phenyldecanoic acid, 8-Phenyloctanoic acid, n-Hexadecanoic acid and 15-Hydroxypentadecanoic acid. The antioxidant scavenging property showed the potential capacity of the herbal remedy to scavenge free radicals against oxidative stress at 24%, 53.8% 1609.9 µM Fe II/ g extract when compared with ascorbic acid. The hematological indexes showed a significant increase in red blood cells, hemoglobin, hematocrit mean corpuscular hemoglobin, mean corpuscular hemoglobin concentrations, mean corpuscular volume, CD4 and CD8 count at day 10 of the male and female rats with the values of RBC (6.72, 7.34, 7.10 × 106/ul) (6.78, 6.75, 6.79 × 106/ul), hematocrit (47.8, 51.5, 49.75%) (48.05, 44.80, 44.60%) and hemoglobin (16.5, 18.05, 17.1 g/dl) (16.6, 15.6, 15.75 g/dl) when compared with the control (p < 0.05). The histo-architectural structure of the bone marrow showed a stimulating effect of myeloid/erythroid cell ratio > 60 in the treatment groups when compared with 40 mg/kg phenylhydrazine alone.ConclusionsIn conclusion, mojeaga herbal remedy elicited hematinic property that validated the folklore report; hence, further evaluation will be required.
Intertextuality and trivialisation in subcultural depictions of violence and criminality related to mental disorders: the case of Spanish punk music
Authors: Pavez Fabian , Saura Erika , Marset Pedro 
Published: February 2022

SummaryPrevious research remarks on the role of the mass media in shaping our world-view and values. It is relevant for the psychiatric field since the literature suggests that the media and artistic representations emphasise violent and criminal behaviours of people with mental disorders. In contrast to the study of other artistic manifestations, depictions in music are much less explored. This article examines the subcultural portrayals of psychiatry-related violent and criminal behaviours in Spanish popular music; particularly, the dimensions of intertextuality and trivialisation. These aspects are relevant since trivialisation may contribute to a distorted and oversimplified view of mental disorders, while intertextuality can play a role in the dissemination, amplification and reinforcement of social beliefs regarding psychiatric problems.
Life expectancy and years of potential life lost in bipolar disorder: systematic review and meta-analysis
Authors: Chan Joe Kwun Nam , Tong CoCo Ho Yi , Wong Corine Sau Man , Chen Eric Yu Hai , Chang Wing Chung 
Published: February 2022

BackgroundThere is increasing research examining excess mortality in people with bipolar disorder using life expectancy and related measures, which quantify the disease impact on survival. However, there has been no meta-analysis to date summarising existing data on life expectancy in those with bipolar disorder.AimsTo systematically review and quantitatively synthesise estimates of life expectancy and years of potential life lost (YPLL) in people with bipolar disorder.MethodWe searched Embase, Medline, PsycINFO and Web of Science databases up to 31 March 2021. We generated pooled life expectancy using random-effects models, and derived YPLL summary estimate by calculating averaged values weighted by sample size of individual studies. Subgroup analyses were conducted for gender, geographical region, study period, a given age (set-age) for lifespan estimation and causes of death. The study was registered with PROSPERO (CRD42021241705).ResultsEleven and 13 studies were included in the review for life expectancy (n = 96 601) and YPLL (n = 128 989), respectively. Pooled life expectancy was 66.88 years (95% CI 64.47–69.28; I2 = 99.9%, P < 0.001), was higher in women than men (70.51 (95% CI 68.61–72.41) v. 64.59 (95% CI 61.16–68.03); z = 2.00, P = 0.003) and was lowest in Africa. Weighted average YPLL was 12.89 years (95% CI 12.72–13.07), and was greatest in Africa. More YPLL was observed when lifespan was estimated at birth than at other set-age. YPLLs attributable to natural and unnatural deaths were 5.94 years (95% CI 5.81–6.07) and 5.69 years (95% CI 5.59–5.79), respectively.ConclusionsBipolar disorder is associated with substantially shortened life expectancy. Implementation of multilevel, targeted interventions is urgently needed to reduce this mortality gap.
Secondary Cytoreductive Surgery in Platinum-Sensitive Recurrent Ovarian Cancer: A Meta-Analysis
Authors: Baek Min-Hyun , Park Eun Young , Ha Hyeong In , Park Sang-Yoon , Lim Myong Cheol , Fotopoulou Christina , Bristow Robert E. 
Published: February 2022

PURPOSEThe survival impact of secondary cytoreductive surgery in patients with platinum-sensitive recurrent ovarian cancer was studied.METHODSWe identified published studies from 1983 to 2021 following our inclusion criteria from MEDLINE, EMBASE, and Cochrane library. To integrate the effect size of single-arm studies, meta-analysis was performed using death rate as a primary outcome. The effect of complete cytoreduction and optimal cytoreduction on survival was evaluated using meta-regression. The pooled death rate was presented with a 95% CI. The publication bias was evaluated with the funnel plot and Egger's test, and sensitivity analysis was performed. To overcome missing death rates, the linear regression model was performed on log-transformed median overall survival (OS) time using study size as a weight.RESULTSThirty-six studies with 2,805 patients reporting death rates were used for this meta-analysis of the 80 eligible studies. There was strong heterogeneity, with the P value of the Cochrane Q test of < 0.0001 and Higgins's I2statistics of 86%; thus, we considered a random effect model. The pooled death rate was 44.2% (95% CI, 39.0 to 49.5), and both the complete and optimal cytoreductions were associated with better survival outcomes as significant moderators in the meta-regression model ( P < .001 and P = .005, respectively). Although 14 studies were located outside the funnel plot, Egger's test indicated no publication bias ( P = .327). A sensitivity analysis excluding 14 studies showed similar results. In the linear regression model on the basis of 57 studies, the median OS time increased by 8.97% and 7.04% when the complete and optimal cytoreduction proportion increased by 10%, respectively, after adjusting other variables.CONCLUSIONSecondary cytoreductive surgery, resulting in maximal tumor resection, significantly prolongs OS in platinum-sensitive recurrent ovarian cancer.
Clinical Validity of Plasma-Based Genotyping for Microsatellite Instability Assessment in Advanced GI Cancers: SCRUM-Japan GOZILA Substudy
Authors: Nakamura Yoshiaki , Okamoto Wataru , Denda Tadamichi , Nishina Tomohiro , Komatsu Yoshito , Yuki Satoshi , Yasui Hisateru , Esaki Taito , Sunakawa Yu , Ueno Makoto , Shinozaki Eiji , Matsuhashi Nobuhisa , Ohta Takashi , Kato Ken , Ohtsubo Koushiro , Bando Hideaki , Hara Hiroki , Satoh Taroh , Yamazaki Kentaro , Yamamoto Yoshiyuki , Okano Naohiro , Terazawa Tetsuji , Kato Takeshi , Oki Eiji , Tsuji Akihito , Horita Yosuke , Hamamoto Yasuo , Kawazoe Akihito , Nakajima Hiromichi , Nomura Shogo , Mitani Ryuta , Yuasa Mihoko , Akagi Kiwamu , Yoshino Takayuki 
Published: February 2022

PURPOSECirculating tumor DNA (ctDNA) genotyping may guide targeted therapy for patients with advanced GI cancers. However, no studies have validated ctDNA genotyping for microsatellite instability (MSI) assessment in comparison with a tissue-based standard.PATIENTS AND METHODSThe performance of plasma-based MSI assessment using Guardant360, a next-generation sequencing–based ctDNA assay, was compared with that of tissue-based MSI assessment using a validated polymerase chain reaction–based method in patients with advanced GI cancers enrolled in GOZILA study, a nationwide ctDNA profiling study. The primary end points were overall percent agreement, positive percent agreement (PPA), and negative percent agreement. The efficacy of immune checkpoint inhibitor therapy was also evaluated.RESULTSIn 658 patients with advanced GI cancers who underwent both plasma and tissue testing for MSI, the overall percent agreement, PPA, and negative percent agreement were 98.2% (95% CI, 96.8 to 99.1), 71.4% (95% CI, 47.8 to 88.7), and 99.1% (95% CI, 98.0 to 99.7), respectively. In patients whose plasma samples had a ctDNA fraction ≥ 1.0%, the PPA was 100.0% (15/15; 95% CI, 78.2 to 100.0). Three patients with MSI-high (MSI-H) tumors detected only by ctDNA genotyping achieved clinical benefits after receiving anti–programmed cell death 1 therapy with the progression-free survival ranging from 4.3 to 16.7 months. One patient with an aggressive cancer of an unknown primary site benefited from pembrolizumab after rapid detection of MSI-H by ctDNA genotyping.CONCLUSIONctDNA genotyping was able to detect MSI with high concordance to validated tissue-based MSI testing, especially in patients with tumors that have sufficient ctDNA shedding. Furthermore, ctDNA genotyping enabled identification of patients with MSI-H tumors who benefited from immune checkpoint inhibitor treatment.
The Role of Lipid Rafts and Membrane Androgen Receptors in Androgen’s Neurotoxic Effects
Authors: Fadeyibi Oluwadarasimi , Rybalchenko Nataliya , Mabry Steve , Nguyen Dianna H , Cunningham Rebecca L 
Published: February 2022

Abstract
Sex differences have been observed in multiple oxidative stress–associated neurodegenerative diseases. Androgens, such as testosterone, can exacerbate oxidative stress through a membrane androgen receptor (mAR), AR45, localized to lipid rafts in the plasma membrane. The goal of this study is to determine if interfering with mAR localization to cholesterol-rich lipid rafts decreases androgen induced neurotoxicity under oxidative stress environments. We hypothesize that cholesterol-rich caveolar lipid rafts are necessary for androgens to induce oxidative stress generation in neurons via the mAR localized within the plasma membrane. Nystatin was used to sequester cholesterol and thus decrease cholesterol-rich caveolar lipid rafts in a neuronal cell line (N27 cells). Nystatin was applied prior to testosterone exposure in oxidatively stressed N27 cells. Cell viability, endocytosis, and protein analysis of oxidative stress, apoptosis, and mAR localization were conducted. Our results show that the loss of lipid rafts via cholesterol sequestering blocked androgen-induced oxidative stress in cells by decreasing the localization of mAR to caveolar lipid rafts.