bluuebunny/crossref_metadata_2025_split huggingface dataset:
Learning Heterogeneous Subgraph Representations for Team Discovery
Authors: Nguyen Hoang , Rad Radin Hamidi , Al-Obeidat Feras , Bagheri Ebrahim , Kargar Mehdi , Srivast Divesh , Szlichta Jaroslaw , Zarrinkalam Fattane 
Published: December 2022

Abstract
The team discovery task is concerned with finding a group of experts from a collaboration network who would collectively cover a desirable set of skills. Most prior work for team discovery either adopt graph-based or neural mapping approaches. Graph-based approaches are computationally intractable often leading to sub-optimal team selection. Neural mapping approaches have better performance, however, are still limited as they learn individual representations for skills and experts and are often prone to overfitting given the sparsity of collaboration networks. Thus, we define the team discovery task as one of learning subgraph representations from heterogeneous collaboration network where the sub-graphs represent teams which are then used to identify relevant teams for a given set of skills. As such, our approach captures local (node interactions with each team) and global (subgraph interactions between teams) characteristics of the representation network and allows us to easily map between any homogeneous and heterogeneous subgraphs in the network to effectively discover teams. Our experiments over two real-world datasets from different domains, namely the DBLP biblio-graphic dataset with 10, 647 papers and IMDB with 4, 882 movies, illustrate that our approach outperforms the state-of-the-art baselines on a range of ranking and quality metrics. More specifically, in terms of ranking metrics, we are superior to the best baseline by approximately 15% on the DBLP dataset and by approximately 20% on the IMDB dataset. Further, our findings illustrate that our approach consistently shows a robust performance improvement over the baselines.
Time-series association based dynamic graph evolution for recommendation
Authors: Xiao Chunjing , Lv Shenkai , Fan Wei , Ip W.H. 
Published: December 2022

Abstract
Modeling the interactions between users and items to accurately predict ratings is very crucial for improving the performance of recommendation. Although existing graph-based methods have achieved great progress in predicting ratings for recommendation, they usually need additional side information which is difficultly obtained, and ignore the temporal associations between items (users) when constructing graphs. In this paper, we propose a time series association based dynamic graph evolution model for recommendation, which can capture not only the information propagation on multiple graphs but also the temporal association between items (users) by constructing a time series item association graph and a user similarity graph. Specifically, the proposed model consists of two main components: recurrent graph construction component and message propagation component. The former recurrently constructs the time series item association graph and the user similarity graph only from the interactions between items (users) to capture the temporal associations between items (users), which further helps the process of constructing two auxiliary graphs. The latter refines user and item representations by aggregating the influence information propagated from multiple high-order neighbors. Finally, the refined representations of users and items are used to predict ratings on all items a user has not interacted with. The experimental results illustrate that our method outperforms the state-of-the-art methods on five real-world datasets.
T cell metabolic insufficiency explains the dysfunctional immune response in advanced renal cell carcinoma.
Authors: Annels Nicola , Denyer Mick , Nicol David , Hazell Steve , Silvanto Anna , Crockett Matthew , Hussain Muddassar , Moller-Levet Carla , Pandha Hardev 
Published: December 2022

Abstract
Renal cell carcinoma (RCC) is considered an immunogenic tumour with a prominent dysfunctional immune cell infiltrate, unable to control tumour growth. Although tyrosine kinase inhibitors and immunotherapy have improved the outlook for some patients, many individuals are non-responders or relapse despite treatment, and then develop progressive disease, cancer symptoms and will have a reduced life expectancy. Following the limited success of cytokine therapy, immunotherapy using ipililumab/nivolumab combination or nivolumab single agent checkpoint-inhibitor therapy has been transformational and reiterated the potential for immune manipulation to significantly impact this disease. There is an urgent need to further improve the potential efficacy of these new targeted immunotherapies as not all patients derive benefit. The immune environment created by the tumour recapitulates that present in chronic viral infections in which inappropriate and excessive antigen stimulation leads to intra-tumoural T-cell exhaustion. These exhausted T-cells exhibit defective proliferative capacities and cytokine production and display an overall phenotype of metabolic insufficiency, characterized by extensive mitochondrial alterations. We set out to comprehensively identify mitochondrial defects in exhausted RCC tumour infiltrating lymphocytes (TILs) and correlate these findings with the clinicopathological characteristics of the tumour and the metabolic tumour microenvironment. The emergence of exhausted RCC CD8 + TILs upon progression into p3-4 advanced stage disease coincided with a significant decrease in expression of PPARGC1A, a key regulator of mitochondrial biogenesis. Down-regulation of PPARGC1A during ccRCC disease progression thus represents a ‘tipping point’ promoting immune dysfunction, cancer progression and poor outcomes from this disease.
Decreased expression of 25-hydroxyvitamin D in peripheral plasma and vitamin D receptor in wound margin tissue associated with diabetic foot ulcers in patients with type 2 diabetes mellitus
Authors: Tang Ying , Huang Yixuan , Luo Li , Xu Murong , Deng Datong , Fang Zhaohui , Zhao Xiaotong , Chen Mingwei 
Published: December 2022

Abstract
Background There are no clinical studies have attempted to elucidate the correlation between vitamin D deficiency and the incidence of diabetic foot osteomyelitis (DFO) .This study to elucidate the expression of 25-hydroxyvitamin D (25(OH)VD) in peripheral plasma (P-25(OH)VD) and vitamin D receptor (VDR) in wound margin tissues (T-VDR) of patients with type 2 diabetes mellitus (T2DM) who presented with diabetic foot ulcer (DFU) and DFO, and identify its correlation with treatment outcomes of DFU and DFO.
Methods 156 T2DM patients with DFU (DFU group), 100 newly diagnosed T2DM patients without DFU (T2DM group), and 100 healthy controls (NC group). DFU group were further categorized into DFO (n = 80) and NDFO subgroups (n = 76). Expression levels of P-25(OH)VD were measured via chemiluminescence, and T-VDR was measured through quantitative real-time PCR.
Results DFU group showed significantly lower P-25(OH)VD expression than in the T2DM group (P < 0.05). DFO group showed significantly lower P-25(OH)VD and T-VDR expression than those in the NDFO group (P < 0.05). Furthermore, P-25(OH)VD and T-VDR expression of DFU group were negatively correlated with ulcer course, Wagner grade, wound infection severity, the detection rate of drug-resistant bacteria, recurrence rate, and amputation rate of foot ulcer (P < 0.05). However, P-25(OH)VD and T-VDR expression were positively correlated with ulcer healing rate after 8 weeks (P < 0.05). Low expression of P-25(OH)VD were an independent risk factor for DFU and DFO (ORDFU = 2.42, ORDFO = 3.05, P < 0.05), and low expression of T-VDR was an independent risk factor for DFO (OR = 2.83, P < 0.05). The area under the ROC curve (AUC) of 25(OH)VD related to the diagnosis of DFU and DFO was 0.821 (95% CI: 0.754 – 0.886, P < 0.001) and 0.786 (95%CI: 0.643 – 0.867, P < 0.001), When establishing a diagnosis of DFO, the AUC of T-VDR was 0.703 (95%CI: 0.618 – 0.853, P < 0.001).
Conclusions Decreased expression of P-25(OH)VD and T-VDR of T2DM patients are closely related to the occurrence, development, and prognosis of DFU and DFO, which can consequently be applied as potential biomarkers and be used to predict DFU and DFO.
Optimizing internal biosecurity on pig farms by assessing movements of farm staff
Authors: Bernaerdt Elise , Díaz Inmaculada , Piñeiro Carlos , Collell Miquel , Dewulf Jeroen , Maes Dominiek 
Published: December 2022

Abstract
For internal biosecurity, it is important to separate different age groups in a pig farm and to stick to specific working lines when visiting the barns. Currently, there is no research on the movements of farm staff on pig farms. The objectives of this observational study were to assess movements of farm staff on pig farms, to assess risky movements and to investigate whether movements differ according to time (week of the batch farrowing system (BFS) and weekday vs. weekend) and unit (farrowing, gestation/insemination, nursery, and fattening unit). Five commercial sow farms participated and on each farm, an internal movement monitoring system was installed. Detection points were installed throughout the farm and workers had to wear a personal beacon. Movement data were collected from 1 December 2019 until 30 November 2020. The following sequence of movements was considered as safe: 1) dressing room, 2) farrowing, 3) gestation/insemination, 4) nursery, 5) fattening, 6) quarantine, and 7) cadaver storage. Movements in the opposite direction were considered as risk, unless a dressing room was visited in between. The total number of movements differed according to week of the BFS, and was highest in insemination and farrowing week. The percentage of risky movements was influenced by week of the BFS for two farms, and was highest around weaning. The percentage of risky movements varied between farms and ranged from 9 to 38%. There were more movements on a weekday compared to a weekend day. There were more movements towards the farrowing and gestation/insemination unit in insemination and farrowing week compared to other weeks of the BFS, but week of the BFS had no impact on movements towards nursery and fattening unit. This study showed that there were a lot of (risky) movements on pig farms and that these movements varied according to week of the BFS, day of the week, and unit. This study creates awareness, which could be a first step in optimizing working lines. Future research should focus on why certain risky movements occur and how these can be avoided to achieve better biosecurity and higher health status on farms.
Effects of Fatigue, Rumination Thinking and Sleep Quality on Hopelessness in Family Caregivers of Cancer Patients
Authors: Cao Zhaoming , Chen Yufu , Zhang Huijun 
Published: December 2022

Abstract
Background
The heavy care burden, long-term dependence of caring for cancer patients, and changing social roles puts family caregivers at high risk of mental disorders and hopelessness. This explored the relationship between fatigue, sleep quality, rumination, and hopelessness, and provides suggestions to maintain caregivers' mental health.
Methods
We investigated 536 family caregivers of cancer patients in three Grade-A hospitals in Liaoning Province who met the inclusion criteria on the Beck hopelessness scale (BHS), fatigue Scale-14 (FS-14), Nolen-Hoeksema ruminative responses scale (RRS), and Pittsburgh sleep quality index (PSQI). Data were analyzed with SPSS 26.0, and Amos 22.0 was used to fit the structural equation model.
Results
The family caregivers had a higher degree of hopelessness and fatigue, while sleep quality, and rumination were positively correlated with hopelessness (r = 0.483–0.906; P < 0.05). Fatigue and sleep quality can indirectly affect hopelessness through rumination thinking, while hopelessness has a direct effect on sleep.
Conclusions
There are multiple action paths between fatigue and sleep quality, rumination thinking, and hopelessness. Family caregivers‘ physical and mental health can be maintained and hopelessness avoided by improving sleep quality, alleviating fatigue, and psychological counselling.
Treatment of dogs with Bravecto® (fluralaner) reduces mosquito survival and fecundity
Authors: Evans Christopher Charles , Normile Dorothy , Gamble Sheryl , Guerino Frank , Dzimianski Michael T. , Moorhead Andrew Riddell 
Published: December 2022

Abstract
Background: Mosquitoes serve as the vector of canine heartworm (Dirofilaria immitis), which represents a significant and persistent threat to canine health. A reduction in the longevity and/or reproductive success of mosquitoes that take a bloodmeal from fluralaner-treated dogs may consequently reduce the local transmission of heartworm and prevent new infections. This study investigated a novel secondary effect of an oral formulation of the ectoparasiticide fluralaner (Bravecto®) against a laboratory strain of mosquito (Aedes aegypti).
Methods: Six dogs were administered a single dose of fluralaner orally in the form of Bravecto® Chews (at the labeled fluralaner dose of 25 mg/kg body weight) while six control dogs received no treatment. Mosquitoes were fed on blood collected from each dog; this was performed prior to treatment and weekly for 15 weeks posttreatment to assess the continued duration of effects as serum fluralaner levels decrease. Mosquito fitness was assessed by three parameters: rate of successful blood feeding, survival, and egg laying.
Results: Blood feeding was equally successful between control and treatment groups. Fluralaner treatment significantly reduced mosquito survival within the first day of blood feeding for 12 weeks posttreatment (efficacy range = 33.2% – 73.3%). Survival of mosquitoes to a potentially heartworm-infective timepoint (14 days postfeeding) was significantly reduced in the fluralaner-treated group at several timepoints, but less consistently (weeks 1, 2, 5, 11, 12, 13, 14, and 15; efficacy range = 49.4% – 91.4%). Egg laying by mosquitoes was almost completely suppressed for the first 13 weeks following treatment (treatment efficacy = 100%).
Conclusions: Mosquitoes fed blood from fluralaner-treated dogs experienced a significant reduction in survival and fecundity. These findings support the potential for reduction in heartworm transmission directly by lethal effects on the vector and indirectly by reduction of the local vector population when mosquitoes are exposed to treated animals.
Secure IPsec VPN Tunnel Establishment Using IKE-Version 2
Authors: Ghann Patricia , MENSAH SELORM OCHERE , OWIREDU JOSEPH 
Published: December 2022

Abstract
Advancement in technology comes with several opportunities and issues. Organizations are able to move their businesses online to reach a greater number of potential customers. Security and privacy in cyberspace are posing a threat to organizations due to establishment of communication links. These connections are based on trust relationships, where resources are permitted to be accessed from one party or the other, it is critical to implement the necessary security measures such that, these established communication links will not be used as a conduit for exploitation. This paper proposes the use of cryptography (IPsec) and its proper implementation to secure virtual communication links over the internet. The objective is to illustrate effective implementation of IPsec to secure L2L (LAN-to-LAN) or S2S (Site-to-Site) communication between systems hosted at two different organizations to promote security. We answer these questions: Is IPsec able to secure traffic between two endpoints over the internet? Is it possible to send traffic not permitted to go through the VPN to reach systems at either side of the VPN tunnel? Proposed model encrypts the entire communication link and any data sent through it. It further guarantees only the nodes permitted to exchange information can communicate over such links.
The Storyteller: Computer Vision Driven Context and Content Generation System
Authors: Haque Anwar ul , Ghani Sayeed 
Published: December 2022

Abstract
The human capability of detecting, understanding, and contextualizing objects in the real world by machines has always been a dream for computer scientists. Along with other important and pending challenges in the field of computer vision, image captioning with context and content is an important research problem. In our research, we attempted to develop a human-like storytelling system that can caption images with the perspective of content, context, syntax, and knowledge. Our methodology is a combination of Capsule Networks for image encoding, Knowledge Graph for content and context awareness, and Transformer Neural Networks for decoding. During feature extraction, spatial, geometrical, and orientational details are extracted using Capsule Networks. To equip our model with content, context, and semantics, the corpus is passed through the Knowledge Graph. The decoding phase is a combination of Knowledge Graph and Transformer Neural Network for knowledge-driven captioning. Dynamic multi-headed attention in the decoder is used for memory optimization. Our model is trained over MSCOCO. The results provide good content and context understanding along with B4: 18.23, M: 19.2, R: 41.1, and C: 54.19. The primary outcome of our research is generating autonomous story-type captions for real-world images.
Molecular approach for identification of Pangasianodon hypophthalmus based on Mitochondrial Cytochrome b Oxidase Subunit I (COI) gene from Pakistan
Authors: MALIK TAYYABA , NAEEM MUHAMMAD 
Published: December 2022

Abstract

The aquaculture industry is dependent on rich fish resources in water bodies. Human activities have led to a rapid decline of fish species. In Asia, the Pangasiidae family is highly valued for its potential for survival and its fillet meat. DNA barcoding is a taxonomic method using genetic markers in organisms mitochondrial DNA (mt DNA) for identification. The phylogeny and identification of Pangasianodon hypophthalmus in the subcontinent is of great concern. For species identification, a precise and rapid technique is DNA barcoding. This method is strongly effective for analyzing the divergence among species. DNA barcoding is more reliable as compared to external morphology. To avoid mislabeling and conservation of species, it is equally useful in juveniles as well as adult stages of fishes. As DNA bar-coding is a taxonomic method that uses small genetic markers in organisms’ mitochondrial DNA (mt DNA) for identification of particular species. In recent study MAGA X and Kimura 2 Parameter was used to evaluate genetic distance and neighbor joining tree was constructed. BOLD and GenBank reveals the nearest identity matches. As mitochondrial cyt-b gene region was successfully used for identifying species and accepted as a standard region for DNA barcoding.
Bioremediation of ore tailing by Aspergillus niger for producing biosynthesized nano fertilizers as plant growth stimulator
Authors: Anjum Sobia , Anjum Fozia , Ilyas Sadia , Bukhari Shazia Anwer , Bokhari Tanveer Hussain , Siddiqi Sajjad Ahmad 
Published: December 2022

AbstractOre Tailing, a rich source of minerals stimulates the researchers to microbially recover valuable metals from this toxic waste to usable for in an eco-friendly manner. In current research,A. nigermetabolites exhibited good potential for metal ions solubilization and further conversion into nano formulation by protein end capping. Synthesis of biorecovered nanoparticles were confirmed by systematic characterization using AAS, UV/VIS, FTIR, SEM and Zetasizer analysis. These BNPs with various concentrations (0.2, 0.4, 0.6, 0.8 and 1.00 ppm) were evaluated for their efficacy on seed germination and seedling growth of wheat (Triticum aestivumL.) by seed priming technique. Seedlings displayed pronounced seed germination (100% ± 0.00) and seedling growth in terms of root and shoot length (8.31 ± 0.18 &7.46 ± 0.15) in the seeds treated with 1.00 ppm of BNPs followed by green synthesized Fe NPs and bulk Fe with germination % (99.64 ± 0.12 & 99.25 ± 0.13) and root and shoot length (7.42 & 6.48cm & 6.62 & 6.26cm) respectively. Minimum growth was observed in water as control representing germination % (96.48 ± 0.13) and seedling growth (4.36 & 4.81 cm). BNP has stimulatory effect on wheat seeds as progressive increase in their germination and physical parameters were observed. So, biosynthesized nanoparticles could be an initiative for the development of nano-biofertilizers of potential importance in agriculture sector.
Naturerleben in Mädchenbüchern um 1900
Authors: Schmidt-Dumont Geralde 
Published: December 2022

[English title and abstract below]
Die poetische Ich-Person des angloamerikanischen Nature Writing seit Henry David Thoreau (1817–1862) begegnet der Natur sehr subjektiv und erschließt sie sich gefühlsmäßig, mit allen Sinnen und durch körperliche Bewegung. Dies ist als Gegenbewegung zur positivistischen Sicht zu sehen, die das Objekt Natur durch Sammeln, Beobachten und Kategorisieren und durch naturwissenschaftlich sachliches Beschreiben beherrschen und sich aneignen will. Die sehr emotionale identifikatorische Begegnung mit der Natur dagegen fußt auf der Naturphilosophie der Romantik und erfuhr in der deutschen Neuromantik eine Wiederbelebung. In der deutschen Jugendliteratur um 1900 fand sie nicht in nonfiktionalen Ich-Texten statt, sondern in Erzählungen, in denen die Autor:innen ihre Protagonistinnen stellvertretend in die Natur eintauchen ließen. Vorbereitend für diese Haltung waren die zivilisationskritischen Bewegungen der Naturheilkunde mit ihrer Betonung der Bedeutung von Licht, Luft und Wasser und der Lebensreform mit ihren Wander- und Freikörpergruppierungen. Ihr neues Naturkonzept fand seinen Niederschlag in Johanna Spyris Heidi, Waldemar Bonsels’ Das Anjekind, Lely Kempins Die heilige Insel und Drude von Gertrud Prellwitz. Diese Werke wurden Kultbücher der Mädchen in der Jugendbewegung und boten ein neues weibliches Körperbild an. Die Naturbetrachtung beinhaltet hier eine quasireligiöse Landschaftsrezeption, und das körperliche Erlebnis der schwärmerischen Hingabe an die Naturelemente geht bis zur Mystifikation.

Experiencing Nature in Girls’ Books Around 1900
The poetic first person of Anglo-American nature writing since Henry David Thoreau (1817–1862) encounters nature subjectively and explores it emotionally, with all their senses and through physical movement. This can be seen as a reaction to the positivist view that aims to master and appropriate nature through collecting, observing and categorising and through scientifically factual description. Emotional, identificational encounters with nature, however, are based on the natural philosophy of Romanticism and were revived in German neo-romanticism. In German young adult literature around 1900, it did not feature in first-person non-fictional narratives, but in stories in which authors let their protagonists immerse themselves in nature. The civilisation-critical movement of naturopathy through light, air and water and the Lebensreform (life reform) movement with its hiking and naturist groups paved the way. This new concept of nature found its expression in Johanna Spyri’s Heidi (1881), Waldemar Bonsels’s Das Anjekind (1913), Lely Kempin’s Die heilige Insel (1917) and Gertrud Prellwitz’s Drude (1920). These became cult novels for girls in the German Youth Movement and offered a new image of the female body. Observing nature became a quasi-religious reception of landscape, and the physical experience of enthusiastic devotion to the elements of nature went as far as mystification.