bluuebunny/crossref_metadata_2025_split huggingface dataset:
Saraiki Proverbs Related to Runaway Women
Authors: Sultan Sajid 
Published: December 2022

The use of proverbs in the Saraiki language shows different male attitudes towards women especially ‘the runaway’. This research-based study is meant to highlight Saraiki proverbs related to runaway women and the negative attitudes they out forward declaring them careless and disobedient. There is a presumption that Saraiki-speaking women are hard working and less demanding. These proverbs present an ideal of Seraiki women as being very tolerant to the cruelties and hardships they face in the name of honor. Proverbs are mostly considered to reflect this taken-for-granted wisdom. This study will explore how these proverbs are deployed and what kinds of consequences they have both positive or negative.
Lawyers in Opera: The Transformation of the Legal Profession
Authors: Høedt-Rasmussen Inger , Nielsen Lise-Lotte 
Published: December 2022

For centuries lawyers, broadly understood as judges, notaries, legal officials and private practicing lawyers, have played important roles in society and been members of a strong profession possessing privileges. Also in operas, from the Italian Commedia dell’arte, ‘Il dottore’, to recent lawyer figures, judges, notaries, lawyers, courtrooms, prisons and legal cultures are exposed. These conditions have influenced the reputation of lawyers. This article contributes with reflections about lawyers’ identity through a fruitful inspiring collaboration between an opera singer and a legal scholar. At three levels of analysis, this explorative study searches for connections between societal requirements (what to do), professional requirements (how to act) and legal and ethical expectations of specific lawyer-like behaviour, morality and good citizenship (who to be). The article brings into a dialogue the world of law and the world of opera and compares the construction of lawyer identities in society with different lawyer roles in opera.
Vitamin D, Calcium and Phosphorus Status Involvement during COVID-19 Infection
Authors: Ali Abdallah Eltoum , Ahmed Mohamed Fathy Seyyed , Suliman Somia Mohammed , Karti Ibrahim Ahamed Ali , Saleh Haidar Eltayeb 
Published: December 2022

Background: COVID-19 is associated with a weak immune system in the human body. Vitamin D plays a role in the body’s immune system and is known to enhance the function of immune cells. In this case, vitamin D inhibits some of the inflammation that can make COVID-19 more severe. The is study aims to determine the serum levels of vitamin D, calcium, and phosphorus in COVID-19 patients.
Methods: This was a cross sectional study conducted during the period from January 2021 to July 2021. 50 COVID-19 patients as a case study and 50 healthy individuals as a control group were included in this study. Blood samples were collected from the study group and measured for vitamin D using Enzyme-linked immunosorbent assay (ELISA) technique. Calcium and phosphate were measured by the Cobas 6000 fully automated analyzer (Roche, Germany).
Results: The study result showed that in COVID-19 patients, vitamin D (27 ± 5 ng/mL), p-value = 0.000, and calcium (10.2 ± 4 mg/dL), p-value = 0.000, in comparison with control. There was a correlation between vitamin D (r = -.771; p =.000) and calcium (r = -.752; p =.000) and the severity of disease.
Conclusions: According to our research, vitamin D deficiency may increase the risk of developing COVID-19 and the risk of developing severe illnesses.
Rare Presentation of Disseminated Tuberculosis in the Present Era of Modern Tuberculosis Management
Authors: Anilkumar Alwin , Manikandan S. , Sreenivasan V. 
Published: December 2022

Background: Disseminated tuberculosis (TB) is defined as two or more noncontiguous sites resulting from lymphohematogenous dissemination of Mycobacterium tuberculosis. In an immunocompetent host, it is uncommon. The presentation varies, and non-specific early infection symptoms can be noted on chest radiography. Early medication beginning is linked to significantly better outcomes in cases of disseminated tuberculosis. The current case report describes the series of incidents that resulted from a 50-year-old man's excessive usage of the corticosteroid medication tablet Betamethasone, which he was taking for a cough and cold related to his chronic obstructive pulmonary disease (COPD).
Case Presentation: A 50-year-old Indian male patient with osteoporosis, drug-induced adrenal insufficiency, and bilateral pleural effusion who is receiving anti-tuberculosis therapy which he is on now is presented to the outpatient department of a tertiary hospital with complaints of fever associated with shivering on & off for 4 months, generalized tiredness. He had a history of loose stools for 2-3 days, small joint pain, left knee joint pain and swelling, loss of weight, and loss of appetite.
Conclusion: The right diagnosis, treatment, patient counseling, diet, and family support helped him recover despite his turbulent recovery phase. As far as steroid therapy is concerned, it is a double-edged sword, meaning that taking (OTC) over-the-counter steroid drugs without first seeking adequate medical advice could have serious negative effects.
Evaluation of Healing and Microbial Responses to Surgical Wounds in Alloxan-induced Diabetic Rabbits
Authors: Onah Jonas Anayo , Fadason Samuel Tanko , Abidoye Ebenezer Olaoluwa , Kadima Kwem , Enem Simon Ikechukwu 
Published: December 2022

The wounds of diabetic patients are associated with delayed healing and microbial invasion. This study evaluated the healing and microbial responses to surgical wounds in diabetic rabbits. Sixteen (16) New Zealand White rabbits were used in this study. They were divided into 4 groups of 4 rabbits each, namely; A, B, C and D. A is the control (non-diabetic and non-wounded), B (diabetic and non-wounded), C (wounded and non-diabetic) and D (wounded and diabetic). Three (3) cm2 skin wounds were created in a standard aseptic condition while diabetes was induced by intravenous administration of 200 mg/kg of alloxan monohydrate. Blood samples were collected from ear vein of each rabbit on days 0, 3, 7, 14, 21 and 28 post-surgery for analysis of blood glucose level. Wound samples were collected on days 3, 7, 14 and 21 to evaluate microbial contaminants. The wounds were examined for exudation and recorded as none (0), scant (1), moderate (2) and large (3) and diameter of wound epithelialization and contraction were determined. The blood glucose concentration of groups B and D from days 3 to 28 ranged between 288.00 ± 40.22 mg/dl to 358.65 ± 25.89 mg/dl), and were significantly higher (P < 0.05) than the corresponding values of groups A and C which ranged from 120.60 mg/dl ± 14.29 to 129.60 ± 8.18 mg/dl. The rate of wound contraction in the C group on day 7 (11.02 ± 2.17%) was significantly higher (P < 0.05) than the D group (2.23 ± 4.60%). Staphylococcus and Pseudomonas subspecies were identified in the wounds of rabbits in groups C and D. It was concluded that alloxan-induced diabetes caused delayed wound healing. At the same time Staphyloccocus and Pseudomonas species were the predominant microorganism detected in the acute wounds of diabetic and non-diabetic rabbits.
Phytochemical Screening and Comparative Evaluation of Antioxidant Activity of Different Parts of Anonidium mannii (Oliv) Engl. et Diels.
Authors: Teinkela Jean Emmanuel Mbosso , Ngbwa Stéphanie Nnanga , Fannang Simone Véronique , Loe Gisèle Marie Marguerite Etame , Meva Francois Eya’ane , Noundou Xavier Siwe 
Published: December 2022

Aims: This study aimed at identifying the phytochemical constituents, to evaluate and compare the in vitro antioxidant potential of the methanolic extracts of the leaves, trunk (wood and bark) and roots (wood and bark) of Anonidium mannii (Oliv) Engl. and Diels which is used in Cameroon for the treatment of rheumatism.
Place and Duration of Study: The work was conducted at the Pharmacochemistry and Natural Substances Laboratories of the Faculty of Medicine and Pharmaceutical Sciences, University of Douala. All the experiments were carried out from the 15th October 2019 to the 31th July 2020.
Methodology: Phytochemical screening was based on conventional techniques focusing on color reactions and precipitation. The evaluation of the antioxidant power was carried out by the method of scavenging the free radical DPPH of the extracts and by reading the absorbance for each concentration at 517 nm.
Results: The phytochemical screening of the extracts revealed the presence of alkaloïds, flavonoïds, anthraquinones, coumarins, terpenes, steroïds, saponins, phenols and anthocyanins. All extracts tested showed antioxidant activity, particularly root wood with an IC50 = 1.85 µg/ml identical to the standard (BHT: Butylhydroxytoluène).
Conclusion: Due to evidence that reactive oxygen species play a causal role in auto-immune diseases, such as rheumatoid arthritis, these results justify the use of the leaves or the stem bark of A. mannii in the traditional pharmacopeia for the treatment of rheumatism. However, the wood of the roots having presented the best activity (IC50 = 1.85 µg/ml). It would be beneficial to suggest this plant part to the local populations for the management of that pathology. This study is the first comparative biological study conducted on the different parts of A. mannii.
Perceptions of Parental Leave Among Ophthalmologists
Authors: Kalra Kisha , Delaney Thomas V. , Dagi Glass Lora R. 
Published: December 2022

ImportanceBenchmarking attitudes surrounding parental leave among posttraining North American ophthalmologists may reveal possible areas for intervention.ObjectiveTo evaluate perceptions of current parental leave policy and culture among posttraining North American ophthalmologists.Design, Setting, and ParticipantsThis nonvalidated survey used a 19-item online questionnaire. A convenience sample of 186 self-identified North American–based ophthalmologists who had completed training was obtained using listservs, residency program coordinators, and social media. Data collection occurred from May to July 2022.Main Outcomes and MeasuresDescriptive analysis demonstrated response frequencies. Pearson χ2 comparison of means was performed for categorical variables. Two-tailed t tests were performed for continuous variables.ResultsAmong the 186 surveys completed, 105 respondents (56.5%) identified as female, 76 (40.9%) worked in academia, 133 (71.5%) were 1 to 20 years out of training, and 156 (83.9%) had children. Attitudes toward stop-the-clock policies, or delays in tenure/promotion/partnership review when taking leave, were mixed. Of 171 respondents, 78 (45.6%) thought that stop-the-clock policies should be optional, 39 (22.8%) thought that they should be required, and 31 (18.1%) thought that they should be removed. Of 76 academicians responding, 56 (73.7%) and 49 (64.5%) were unaware if their institution had a stop-the-clock policy for tenure review or promotion review, respectively. Male and female respondents differed in feeling comfortable with taking leave (36 of 66 [54.5%] vs 67 of 90 [74.4%], respectively; P = .04), as well as in their ratings of stress about peer perception on a scale of 0 to 10 (3.70 vs 4.81, respectively; P = .05). Private practitioners and academicians differed in confirmation of leave options for both parents (52 of 101 [51.5%] vs 49 of 69 [71.0%], respectively; P = .02) and ratings of financial stress (7.10 vs 5.43, respectively; P = .004) and research considerations (1.60 vs 3.85, respectively; P &amp;lt; .001).Conclusions and RelevanceResults of this survey study support the hypothesis that demographic factors affect attitudes toward parental leave among posttraining ophthalmologists; policies could be better publicized. Feelings regarding policies and leave were mixed. These findings should be viewed as hypothesis generating because the survey was not validated and the associations provided could be due to confounding factors.
The ubiquitin‐like protein Hub1/UBL‐5 functions in pre‐mRNA splicing in Caenorhabditis elegans
Authors: Kolathur Kiran Kumar , Sharma Pallavi , Kadam Nagesh Y. , Shahi Navneet , Nishitha Ane , Babu Kavita , Mishra Shravan Kumar 
Published: December 2022

The ubiquitin‐like protein Hub1/UBL‐5 associates with proteins non‐covalently. Hub1 promotes alternative splicing and splicing of precursor mRNAs with weak introns in yeast and mammalian cells; however, its splicing function has remained elusive in multicellular organisms. Here, we demonstrate the splicing function of Hub1/UBL‐5 in the free‐living nematode Caenorhabditis elegans. Hub1/UBL‐5 binds to the HIND‐containing splicing factors Snu66/SART‐1 and PRP‐38 and associates with other spliceosomal proteins. C. elegans hub1/ubl‐5 mutants die at the Larval 3 stage and show splicing defects for selected targets, similar to the mutants in yeast and mammalian cells. UBL‐5 complemented growth and splicing defects in Schizosaccharomyces pombe hub1 mutants, confirming its functional conservation. Thus, UBL‐5 is important for C. elegans development and plays a conserved pre‐mRNA splicing function.
Hierarchical planning and reasoning about partially ordered plans—From theory to practice
Authors: Bercher Pascal 
Published: December 2022

AbstractThis invited paper (part of the New Faculty Highlights Invited Speaker Program of AAAI'21*) surveys my work done until today. The reviewed work focuses on hierarchical task network (HTN) planning as well as on partial order causal link (POCL) planning. Lines of research include theoretical investigations (mostly computational complexity analyses), heuristic search, as well as the practical application of the technology for planning‐based assistants, which support a human user in carrying out various tasks.
The impact of Omicron pandemic and COVID‐19 vaccination on the pancreatic adenocarcinoma patients
Authors: Fu Ningzhen , Jiang Yu , Xu Zhiwei , Yang Meng , Peng Chenghong , Deng Xiaxing , Zhao Shulin , Shen Baiyong 
Published: December 2022

AbstractBackgroundThe coronavirus disease 2019 (COVID‐19) pandemic resulted in enormous medical and economic burden worldwide during the past 3 years. The vaccination was deemed the effective option to prevent the severe symptoms, and especially recommended among cancer patients. Shanghai experienced the first lockdown during the recent Omicron pandemic since 2019. How patients with pancreatic adenocarcinoma (PAC) suffered from the pandemic and how vaccination influenced their oncological outcomes were unexplored yet.MethodThe retrospective study was carried out in a high‐volume referral center including 1157 consecutively enrolled patients with PAC experiencing the COVID‐19 pandemic. The primary outcome was the overall survival (OS).ResultsLimited postoperative patients (9.21%) received the vaccination. The lockdown in Shanghai (April to May, 2022) was not observed impacting the survival prognoses of patients with PAC. Though vaccination was not significantly associated with OS itself (adjusted hazard ratio (aHR): 2.032 [0.940–4.391], p = 0.071), it was discovered to synergistically improve the chemotherapy effect in the multivariate analyses (interaction p = 0.023).ConclusionThe vaccination itself did not influence the survival prognoses of patients with PAC. A potential positive interaction was observed between chemotherapy and vaccination despite the limited follow‐up time. The postoperative patients should consider the vaccination more. The patients with PAC did not suffer worse prognostic outcomes from the strict sanitary policy during the wave of COVID‐19 pandemic in Shanghai.
Using chronic recordings from a closed‐loop neurostimulation system to capture seizures across multiple thalamic nuclei
Authors: Kundu Bornali , Arain Amir , Davis Tyler , Charlebois Chantel M. , Rolston John D. 
Published: December 2022

AbstractWe report the case of a patient with unilateral diffuse frontotemporal epilepsy in whom we implanted a responsive neurostimulation system with leads spanning the anterior and centromedian nucleus of the thalamus. During chronic recording, ictal activity in the centromedian nucleus consistently preceded the anterior nucleus, implying a temporally organized seizure network involving the thalamus. With stimulation, the patient had resolution of focal impaired awareness seizures and secondarily generalized seizures. This report describes chronic recordings of seizure activity from multiple thalamic nuclei within a hemisphere and demonstrates the potential efficacy of closed‐loop neurostimulation of multiple thalamic nuclei to control seizures.
Altered brain white matter structural motor network in spinocerebellar ataxia type 3
Authors: Chen Xin‐Yuan , Huang Zi‐Qiang , Lin Wei , Li Meng‐Cheng , Ye Zhi‐Xian , Qiu Yu‐Sen , Xia Xiao‐Yue , Chen Na‐Ping , Hu Jian‐Ping , Gan Shi‐Rui , Chen Qun‐Lin 
Published: December 2022

AbstractObjectivesSpinocerebellar ataxia type 3 is a disorder within the brain network. However, the relationship between the brain network and disease severity is still unclear. This study aims to investigate changes in the white matter (WM) structural motor network, both in preclinical and ataxic stages, and its relationship with disease severity.MethodsFor this study, 20 ataxic, 20 preclinical SCA3 patients, and 20 healthy controls were recruited and received MRI scans. Disease severity was quantified using the SARA and ICARS scores. The WM motor structural network was created using probabilistic fiber tracking and was analyzed using graph theory and network‐based statistics at global, nodal, and edge levels. In addition, the correlations between network topological measures and disease duration or clinical scores were analyzed.ResultsPreclinical patients showed increasing assortativity of the motor network, altered subnetwork including 12 edges of 11 nodes, and 5 brain regions presenting reduced nodal strength. In ataxic patients assortativity of the motor network also increased, but global efficiency, global strength, and transitivity decreased. Ataxic patients showed a wider altered subnetwork and a higher number of reduced nodal strengths. A negative correlation between the transitivity of the motor network and SARA and ICARS scores was observed in ataxic patients.InterpretationChanges to the WM motor network in SCA3 start before ataxia onset, and WM motor network involvement increases with disease progression. Global network topological measures of the WM motor network appear to be a promising image biomarker for disease severity. This study provides new insights into the pathophysiology of disease in SCA3/MJD.
Fast Ion Transport in Li‐Rich Alloy Anode for High‐Energy‐Density All Solid‐State Lithium Metal Batteries
Authors: Gao Xuejie , Yang Xiaofei , Jiang Ming , Zheng Matthew , Zhao Yang , Li Ruying , Ren Wenfeng , Huang Huan , Sun Runcang , Wang Jiantao , Singh Chandra Veer , Sun Xueliang 
Published: December 2022

AbstractAll‐solid‐state Li batteries (ASSLBs) with solid‐polymer electrolytes are considered promising battery systems to achieve improved safety and high energy density. However, Li dendrite formation at the Li anode under high charging current density/capacity has limited their development. To tackle the issue, Li‐metal alloying has been proposed as an alternative strategy to suppress Li dendrite growth in ASSLBs. One drawback of alloying is the relatively lower operating cell voltages, which will inevitably lower energy density compared to cells with pure Li anode. Herein, a Li‐rich Li13In3 alloy electrode (LiRLIA) is proposed, where the Li13In3 alloy scaffold guides Li nucleation and hinders Li dendrite formation. Meanwhile, the free Li can recover Li's potential and facilitate fast charge transfer kinetics to realize high‐energy‐density ASSLBs. Benefitting from the stronger adsorption energy and lower diffusion energy barrier of Li on a Li13In3 substrate, Li prefers to deposit in the 3D Li13In3 scaffold selectively. Therefore, the Li–Li symmetric cell constructed with LiRLIA can operate at a high current density/capacity of 5 mA cm−2/5 mAh cm−2 for almost 1000 h.
Programmed Catalytic Therapy and Antigen Capture‐Mediated Dendritic Cells Harnessing Cancer Immunotherapies by In Situ‐Forming Adhesive Nanoreservoirs
Authors: Yalamandala Bhanu Nirosha , Huynh Thi My Hue , Chiang Min‐Ren , Weng Wei‐Han , Chang Chien‐Wen , Chiang Wen‐Hsuan , Hu Shang‐Hsiu 
Published: December 2022

AbstractT lymphocyte recruitment and infiltration promises to suppress the most devastating metastatic tumors for immunotherapy. However, the immune privilege and low vaccine immunogenicity usually reduces the presence of lymphocytes in tumors, especially for invading metastatic clusters. Here, an adhesive catalytic nanoreservoir (CN) containing manganese dioxide (MnO2) and catechol‐functionalized magnetic metal organic framework for the antigens capture and delivery is reported. The intravenously injected CN accumulates at tumor via the marginated target and in situ forming gel for antigen capture. At tumor site, CN releases Mn2+ for redox reactions by depleting glutathione (GSH) and Fenton‐like activity, i.e., chemodynamic therapy (CDT). Accompanying with hyperthermia, CDT promote the tumor to release the tumor‐associated antigens including neoantigens and damage‐associated molecular patterns. Then, the gels with catechol groups act as antigen reservoirs and deliver the autologous tumor‐associated antigens to dendritic cells, achieving sustained immune stimulation. The in situ‐forming catalytic nanoreservoir at lung metastasis as a magnetothermal‐induced antigen reservoir effectively inhibited the tumor in 60 days and increased the survival rate.
Self‐Aided Batch Growth of 12‐Inch Transfer‐Free Graphene Under Free Molecular Flow
Authors: Liu Bingzhi , Sun Zhongti , Cui Kejian , Xue Zaikun , Li Zhi , Wang Wen , Gu Wei , Zheng Kaiqiang , Liu Ruojuan , Zhao Yu , Rümmeli Mark H. , Gao Xuan , Sun Jingyu , Liu Zhongfan 
Published: December 2022

AbstractDirect synthesis of large‐area graphene on functional substrates via chemical vapor deposition has become a frontier research stream targeting practical applications. However, the batch production of transfer‐free graphene film with favorable quality and homogeneity remains a grand challenge. Herein, the direct growth of 12‐inch‐sized graphene is demonstrated over fused quartz in a batch manner. The key design of the synthetic route is the construction of a nano‐scale compartment to allow the formation of free molecular flow during growth, as well as to trap the hydroxyl species in situ released from the quartz substrates. Density functional theory calculations reveal that the hydroxyl species help decrease the energy barrier for feedstock decomposition and facilitate the carbon attachment to boost graphene growth. Thus‐prepared graphene possesses excellent optical transmittance (96% ± 1%) and electrical properties (1.22 ± 0.08 kΩ sq‒1). These findings unlock new opportunities for achieving batch production of graphene‐skinned functional materials with practical scalability and quality toward emerging uses.