bluuebunny/crossref_metadata_2025_split huggingface dataset:
γ‐Aminobutyric acid and oxalic acid contents and angiotensin‐converting enzyme inhibitory activity of spinach juices cofermented with Levilactobacillus brevisGABA100 and other lactic acid bacteria
Authors: Kim Moon Joo , Lim Taehwan , Kim Jaecheol , Ji Geun Eog , Lee Haeseong , Lee Kiuk , Kim Ryun Hee , Hwang Keum Taek 
Published: August 2022

SummaryThis study aimed to develop fermented spinach juice with enhanced γ‐aminobutyric acid (GABA) level and angiotensin‐converting enzyme (ACE) inhibitory activity and reduced oxalic acid level. We cofermented spinach juice with Levilactobacillus brevis GABA100 and oxalic acid‐degrading bacteria (Lactobacillus gasseri HHuMin D, Lactobacillus sakei RH1114, Lactobacillus acidophilus 19L5, or Limosilactobacillus fermentum BH03). GABA levels were not different among all the fermented juices except for the juice cofermented with L. brevis GABA100 and L. fermentum BH03. Oxalic acid decreased in the cofermented juices. The most increase in ACE inhibitory activity was observed in the juice cofermented with L. brevis GABA100 and L. sakei RH1114. Peptides (IVVGPPPP, PQTETKASVGFKAG and QIIGPVLD) produced during the cofermentation showed a positive correlation with the ACE inhibitory activity of the juice. These results suggest that spinach juice cofermented with L. brevis GABA100 and L. sakei RH1114 may have potential applications for the management of hypertension.
Foreign direct investment: robustness analysis of an attractiveness index
Authors: Zambujal‐Oliveira João , Amaral José 
Published: August 2022

AbstractOne of the most heavily employed tools to define countries' policies are the attractiveness indexes. The main purpose of our paper is to formally verify the capacity of an attractiveness index to describe the phenomenon of Foreign Direct Investment (FDI). Severe weaknesses were detected through the use of a framework (principal components analysis and Cronbach's alpha reliability) to analyse indexes, regarding the theoretical background and the adequate selection of indicators, especially the ones from the bottom. Additionally, the study demonstrated that the analyzed FDI attractiveness index built to formally aggregate the factors that impacts foreign direct investment can hardly be applied to emerging economies.
Skin hydration measurement and the prediction of the early development of pressure ulcers among at risk adults: A systematic review
Authors: Wilson Hannah , Avsar Pinar , Patton Declan , Budri Aglecia Moda Vitoriano , Moore Zena 
Published: August 2022

AbstractThis systematic review aimed to examine skin hydration and determine if this biophysical parameter can predict pressure ulcer development in at risk adults. A literature search was conducted in March 2022, using PubMed, CINAHL, SCOPUS, Cochrane, and EMBASE databases. A total of 1727 records were returned, with 9 studies satisfying the inclusion criteria. Data were extracted using a pre‐designed extraction tool and a narrative synthesis of the data was undertaken. The methodological quality of the included articles was assessed using the evidence‐based librarianship checklist. Included studies were published between 1997 and 2021, with most using a prospective cohort design (88.9%, n = 8). The mean sample size was 74 participants (SD = 38.6; median 71). All studies measured skin hydration objectively, with 55.6% (n = 5) using the Corneometer® CM825 and 33.3% (n = 3) of studies reported a statistically significant association between skin hydration and pressure ulcer development. The mean evidence‐based librarianship percentage was 66.6% (SD: 20.7%), however, only 33.3% (n = 3) of studies scored ≥75%, indicating validity. The quality of included studies, methodology variation, and reported results has reduced the homogeneity of outcomes. This review highlights the requirement for future research evidence to ascertain the role of skin hydration in pressure ulcer development.
Nursing skills required across natural and man‐made disasters: A scoping review
Authors: Su Ya , Wu Xi Vivien , Ogawa Natsuka , Yuki Michiko , Hu Yun , Yang Yan 
Published: August 2022

AbstractAimsTo map the nursing skills required for different types of disasters.DesignThis was a scoping review of research studies conducted between July and August 2021. We conducted a systematic literature search of nine electronic databases from inception till July 2021, and an updated search was done in April 2022. This review is based on the methodological framework of Arksey and O'Malley (2005), which was further refined by the Joanna Briggs Institute.Data SourcesA range of electronic databases was searched systematically, including CINAHL, Cochrane, Embase, MEDLINE, PsycINFO, PubMed, Web of Science, CNKI and Ichushi‐Web. Articles published in Chinese, English and Japanese were selected for the review.Review MethodsThe PCC model was used to frame the inclusion criteria. Studies were screened, appraised and extracted by two reviewers, and the study findings were narratively synthesized.ResultsWe identified nursing skills for five types of natural disasters including (1) earthquakes, (2) typhoons, (3) tsunamis, (4) marine disasters and (5) infectious diseases and three man‐made disasters: (1) radiation disasters, (2) bioterrorism and (3) war. Among these, there are five types of common professional skills nurses are required to possess including casualty triage, observation and monitoring, basic first aid techniques, psychological care and communication skills. In addition, it was shown that different disasters require different specific professional skills.ConclusionThis scoping review explored the disaster nursing skills required for eight types of disasters and provides evidence for future education and training. Further research is needed to build more accurate scenario‐based simulation training programs to provide more insights into future disaster precision nursing.ImpactThis scoping review provides evidence for future education and training in disaster nursing to improve nurses’ knowledge and competencies in dealing with the different types of disaster situations.
Exploring the effects of automatic speech recognition technology on oral accuracy and fluency in a flipped classroom
Authors: Jiang Michael Yi‐Chao , Jong Morris Siu‐Yung , Lau Wilfred Wing‐Fat , Chai Ching‐Sing , Wu Na 
Published: August 2022

AbstractBackgroundWhile automatic speech recognition (ASR) is increasingly used for commercial purposes, its influence on the learners' linguistic performance in terms of oral complexity, accuracy and fluency was under‐explored. To date, few studies have been conducted to investigate how the dictation ASR technology could be incorporated into language classrooms to facilitate the learners' language acquisition.ObjectivesThis study aimed to examine the effects of ASR‐based technology on English learners' oral accuracy and fluency and depict the corresponding development trajectories.MethodsA total of 160 first‐year university students were enrolled in a 14‐week quasi‐experiment based on a longitudinal research design. Both treatment and control groups were taught with the flipped classroom approach, but the students in the treatment group were particularly required to undertake a pre‐class task with ASR technology. Students' Unit Task performance was audio‐recorded, and the metrics of oral accuracy and fluency were coded and computed based on the recording transcripts. A two‐way repeated measures ANCOVA was conducted to investigate the between‐ and within‐subjects effects as well as the corresponding interaction effects.ResultsIn terms of the between‐subjects effect, the treatment group outperformed the control group on phonological accuracy, speed fluency and repair fluency. In terms of the within‐subjects effect, significant gains in lexical and morphosyntactic accuracy were witnessed over time in both groups, but the performance of the treatment group tended to be more stable. On all the fluency metrics and phonological accuracy, no significant within‐subjects improvement was seen over time.ImplicationsThe development of oral accuracy may generate a negative impact on that of fluency. Therefore, course developers and teachers need to design special tasks and provide conditions conducive to the development of the students' oral fluency. Moreover, the mobile‐based dictation ASR application could incorporate adaptive artificial intelligence, which may escalate the students' fossilization of learner interlanguage.
Artificial intelligence software standardizes electrogram‐based ablation outcome for persistent atrial fibrillation
Authors: Seitz Julien , Durdez Théophile Mohr , Albenque Jean P. , Pisapia André , Gitenay Edouard , Durand Cyril , Monteau Jacques , Moubarak Ghassan , Théodore Guillaume , Lepillier Antoine , Zhao Alexandre , Bremondy Michel , Maluski Alexandre , Cauchemez Bruno , Combes Stéphane , Guyomar Yves , Heuls Sébastien , Thomas Olivier , Penaranda Guillaume , Siame Sabrina , Appetiti Anthony , Milpied Paola , Bars Clément , Kalifa Jérôme 
Published: August 2022

AbstractIntroductionMultiple groups have reported on the usefulness of ablating in atrial regions exhibiting abnormal electrograms during atrial fibrillation (AF). Still, previous studies have suggested that ablation outcomes are highly operator‐ and center‐dependent. This study sought to evaluate a novel machine learning software algorithm named VX1 (Volta Medical), trained to adjudicate multipolar electrogram dispersion.MethodsThis study was a prospective, multicentric, nonrandomized study conducted to assess the feasibility of generating VX1 dispersion maps. In 85 patients, 8 centers, and 17 operators, we compared the acute and long‐term outcomes after ablation in regions exhibiting dispersion between primary and satellite centers. We also compared outcomes to a control group in which dispersion‐guided ablation was performed visually by trained operators.ResultsThe study population included 29% of long‐standing persistent AF. AF termination occurred in 92% and 83% of the patients in primary and satellite centers, respectively, p = 0.31. The average rate of freedom from documented AF, with or without antiarrhythmic drugs (AADs), was 86% after a single procedure, and 89% after an average of 1.3 procedures per patient (p = 0.4). The rate of freedom from any documented atrial arrhythmia, with or without AADs, was 54% and 73% after a single or an average of 1.3 procedures per patient, respectively (p < 0.001). No statistically significant differences between outcomes of the primary versus satellite centers were observed for one (p = 0.8) or multiple procedures (p = 0.4), or between outcomes of the entire study population versus the control group (p > 0.2). Interestingly, intraprocedural AF termination and type of recurrent arrhythmia (i.e., AF vs. AT) appear to be predictors of the subsequent clinical course.ConclusionVX1, an expertise‐based artificial intelligence software solution, allowed for robust center‐to‐center standardization of acute and long‐term ablation outcomes after electrogram‐based ablation.
Impact of blood involvement on efficacy and time to response with mogamulizumab in mycosis fungoides and Sézary syndrome
Authors: Beylot‐Barry Marie , Booken Nina , Weishaupt Carsten , Scarisbrick Julia , Wu Wende , Rosen Jan‐Paul , Medley Michael C. 
Published: August 2022

AbstractBackgroundCutaneous T‐cell lymphomas (CTCL) are rare types of non‐Hodgkin lymphoma, which present in skin. Mycosis fungoides (MF) and Sézary syndrome (SS) are subtypes which make up two‐thirds of all CTCL cases. The phase 3 MAVORIC study (NCT01728805) compared mogamulizumab to vorinostat in MF and SS patients, with post hoc data showing a trend for higher efficacy in mogamulizumab‐treated patients as baseline blood tumour burden increases.ObjectivesThe aim of this study was to use updated post hoc analyses in order to examine the efficacy of mogamulizumab and vorinostat in MF patients when stratified by baseline blood involvement and to determine what factors affect time‐to‐global and time‐to‐skin response to inform clinical follow‐up.MethodsPost hoc analyses were carried out using data from MAVORIC. Overall response rate (ORR), progression‐free survival (PFS) and time‐to‐next‐treatment (TTNT) data were used to assess efficacy in patients with MF. Time‐to‐global response (TTR) was examined by disease subtype, by blood involvement in MF patients, and time‐to‐skin response was examined by blood involvement in MF patients.ResultsNumerically superior results were seen for ORR, PFS and TTNT in mogamulizumab‐treated patients with MF compared with vorinostat, with a trend for outcomes improving with increasing baseline blood class. Statistically significant results for mogamulizumab compared with vorinostat were seen for MF B1 pts for PFS (8.43 vs. 2.83 months, p = 0.003) and TTNT (11.9 vs. 3.13 months, p = 0.002), and for MF B2 pts for ORR (46.2 vs. 9.1 months, p = 0.033).ConclusionsIn mogamulizumab‐treated MF patients, ORR and PFS were seen to improve with increasing blood involvement, which led to improved TTNT. TTR was more predictable for mogamulizumab‐treated MF patients with blood involvement, and skin response may take longer than previously reported in some patients.
Artificially perforated holes in stems of small hogweed mimic ecosystem engineering by a moth
Authors: Bethe Sanne E. , Gols Rieta , Harvey Jeffrey A. 
Published: August 2022

AbstractEcosystem engineers are species that manipulate the physical state of ecosystems and thereby affect the behaviour and ecology of other species. Mature larvae of the parsnip webworm, Depressaria radiella Goeze, chew holes in the hollow stems of Heracleum sphondylium L. into which they pupate. The stems are separated into several compartments that are separated by filamentous membranes. Holes excavated by webworm larvae attract several beneficial species of arthropods that use them for shelter in autumn, including the common earwig (Forficula auricularia L.) and the common rough woodlouse (Porcellio scaber Latreille). If artificially made holes mimic the engineering effect of D. radiella, they could be made to attract (local) communities of beneficial arthropods and perhaps facilitate overwintering habitat. We conducted a field experiment to determine whether artificial holes perforated into stem compartments of H. sphondylium mimic the natural situation with D. radiella. At five sites near the city of Leiden, the Netherlands, H. sphondylium plants were exposed to different treatments: a single hole perforated in the first, second or third stem compartment, or in all three compartments. After 3 weeks, arthropod numbers were counted inside and around hogweed stems. The arthropod community in the stems differed from that surrounding the stems; the latter consisted mainly of woodlice and wolf spiders, whereas in the stems, in addition to woodlice, many earwigs were found and no wolf spiders. Both artificial and webworm‐excavated holes that were present at one site were used by woodlice and earwigs. The position of the holes along the stem did not affect the number of arthropods found in that segment, although the arthropods exhibited a tendency to move up the stems. The results show that artificial holes mimic webworm‐excavated holes in that both attract the same species of beneficial arthropods.
Lethal acute diarrhea associated with Clostridioides difficile toxin A and B in a buffy‐tufted‐ear marmoset (Callithrix aurita)
Authors: de Carvalho Thaynara Parente , dos Santos Daniel Oliveira , Oliveira Ayisa Rodrigues , Vasconcelos Izabela Magalhães Arthuso , Tinoco Herlandes Penha , Coelho Carlyle Mendes , Carvalho Gabriela Muniz , Xavier Rafael Gariglio Clark , Silva Rodrigo Otávio Silveira , Paixão Tatiane Alves , Santos Renato de Lima 
Published: August 2022

AbstractThis is a case of lethal acute diarrhea associated with a mild neutrophilic enteritis in a buffy‐tufted‐ear marmoset (Callithrix aurita) with detection of A/B toxins and isolation of a toxigenic clade 3 Clostridioides difficile strain (A+B+CDT+, ST5), which should be considered as a potential cause of enteritis in this species.
A uniformity correction method to reduce scan time for 7T sodium imaging of brain tumors
Authors: Kim Sanghoon , Merugumala Sai , Lin Alexander Peter 
Published: August 2022

AbstractBackground and PurposeSodium imaging shows great potential for the characterization of brain tumors. Intensity correction is required but the additional scan time is costly. Recent developments can halve the time but were optimized in normal brains and may not be applicable in brain tumor imaging. We aim to develop an individualized uniformity correction for sodium imaging optimized for brain tumor patients that reduces scan time but provides high‐resolution images for clinical practice.MethodsTwo‐, 4‐, and 6‐mm iso‐cubic voxel resolution birdcage coil images were used to calculate the 2‐mm iso‐cubic voxel individual sensitivity maps in healthy subjects (n = 3). Cut profiles were compared to determine the optimal approach. In addition, a 3‐dimensional phantom was developed to test a generalized uniformity correction approach in both healthy subjects (n = 3) and tumor patients (n = 3).ResultsThe cut profiles showed that the average correlation coefficient between 2‐ and 4‐mm birdcage image correction results wasr = .9937, andr = .9876 for 2‐ and 6‐mm birdcage images. The correlation result between individual map correction and phantom map correction wasr = .9817.ConclusionThe 4 mm birdcage coil image provided the optimal approach for both as a compromise between the time‐savings effect and image quality. This method allows for a 2‐mm iso‐cubic voxel resolution clinical sodium scan within 12 minutes. We also presented prescanned phantom sensitivity map results, which were designed to cover all patient head sizes. This approach provides an alternative solution in more time‐sensitive cases.
Antioxidant monoammonium glycyrrhizinate alleviates damage from oxidative stress in perinatal cows
Authors: Zhang Cai , Li Chenxu , Shao Qi , Meng Sudan , Wang Xueying , Kong Tao , Li Yu 
Published: August 2022

AbstractThis study was conducted to evaluate the antioxidant capability of dietary supplementation with monoammonium glycyrrhizinate (MAG) in perinatal cows. Glycyrrhizic acid has been shown to have strong antioxidant activity and we hypothesised that the aglycone of glycyrrhizin and MAG, could reduce damage from oxidative stress in perinatal cows by enhancing antioxidant capacity. Blood and milk samples were collected from three groups of healthy perinatal cows that were similar in body weight, parity, milk yield in the last milk cycle, etc., receiving dietary MAG supplementation ([Day 0 = parturition]: 0 g/day, [n = 13)] 3 g/day [n = 13] or 6 g/day [n = 11]) from −28 to 56 day (0 day = parturition). Compared with 0 g/day controls (CON), milk fat was significantly decreased in cows fed with MAG, and 3 g/day had the greatest effect. A diet containing 3 g/day MAG decreased the serum alanine aminotransferase (ALT) level compared with CON at −7 day post‐partum. ALT was also lower at 5 day post‐partum in cows fed with 3 g/day MAG compared to 6 g/day. The administration of 3 g/day and 6 g/day MAG decreased serum aspartate transaminase (AST) at 3 day post‐partum. Supplementation of MAG in cows increased total antioxidant capacity (T‐AOC) in serum, and cows given 3 g MAG per day had higher T‐AOC than controls on post‐partum 7 day. At the end of the experiment, we isolated and cultured primary hepatocytes to determine the effect of MAG on oxidative stress caused by incubation with the sodium oleate (SO). SO increased lipid synthesis, but pre‐treatment with MAG prevented the fatty buildup. SO treatment increased AST and ALT levels and malondialdehyde concentration, but decreased T‐AOC and superoxide dismutase (SOD). Incubation with MAG increased antioxidant capacity and inhibited oxidant damage in bovine hepatocytes. SO stimulated expression of the antioxidant genes, NAD(P)H quinone dehydrogenase 1 (NQO1) and SOD1, in the nuclear factor erythroid 2‐related factor 2 (NRF2) pathway, and catalase 1 (CAT1); this increase was accentuated by MAG pre‐treatment. The results suggest that MAG can alleviate the damage caused by oxidative stress in perinatal cows by enhancing antioxidant activity.
Fibrosis nonalcoholic steatohepatitis index validation and applicability considering glycaemic severity and T2D duration
Authors: Pina Ana , Meneses Maria João , Ribeiro Rogério T. , Raposo João F. , Macedo Maria Paula 
Published: August 2022

AbstractNonalcoholic fatty liver disease (NAFLD) diagnosis without using invasive methods is extremely challenging, highlighting the need for simple indexes for this end. Recently, the fibrotic nonalcoholic steatohepatitis index (FNI) was developed and proposed as an affordable non‐invasive score calculated with aspartate aminotransferase, high‐density lipoprotein cholesterol and haemoglobin A1c. Herein, and given the link between NAFLD and diabetes, we aimed at validating FNI in a population with type 2 diabetes (T2D), also considering diabetes duration and glycaemic severity. The performance of FNI was higher than FIB‐4 (AUROC = 0.89 vs 0.67, respectively). Additionally, using 0.1 as the rule‐out cut‐off of FNI, the sensitivity was 0.99 and the positive predictive value was 0.19. Both duration of diabetes and A1c did not impact FNI performance. In sum, FNI is a valuable score for predicting fibrotic nonalcoholic steatohepatitis not only for primary care units but also for diabetes specialized care.
The microbiome of the pelagic tunicate Dolioletta gegenbauri: A potential link between the grazing and microbial food web
Authors: Pereira Tiago J. , Walters Tina L. , El‐Shaffey Hisham M. , Bik Holly M. , Frischer Marc E. 
Published: August 2022

AbstractBloom‐forming gelatinous zooplankton occur circumglobally and significantly influence the structure of pelagic marine food webs and biogeochemical cycling through interactions with microbial communities. During bloom conditions especially, gelatinous zooplankton are keystone taxa that help determine the fate of primary production, nutrient remineralization, and carbon export. Using the pelagic tunicate Dolioletta gegenbauri as a model system for gelatinous zooplankton, we carried out a laboratory‐based feeding experiment to investigate the potential ecosystem impacts of doliolid gut microbiomes and microbial communities associated with doliolid faecal pellets and the surrounding seawater. Metabarcoding targeting Bacteria and Archaea 16S rRNA genes/Archaea) and qPCR approaches were used to characterize microbiome assemblages. Comparison between sample types revealed distinct patterns in microbial diversity and biomass that were replicable across experiments. These observations support the hypothesis that through their presence and trophic activity, doliolids influence the structure of pelagic food webs and biogeochemical cycling in subtropical continental shelf systems where tunicate blooms are common. Bacteria associated with starved doliolids (representative of the resident gut microbiome) possessed distinct low‐biomass and low‐diversity microbial assemblages, suggesting that the doliolid microbiome is optimized to support a detrital trophic mode. Bacterial genera Pseudoalteromomas and Shimia were the most abundant potential core microbiome taxa, similar to patterns observed in other marine invertebrates. Exploratory bioinformatic analyses of predicted functional genes suggest that doliolids, via their interactions with bacterial communities, may affect important biogeochemical processes including nitrogen, sulphur, and organic matter cycling.