bluuebunny/crossref_metadata_2025_split huggingface dataset:
OVERVIEW OF MITOXANTRONE-A POTENTIAL CANDIDATE FOR TREATMENT OF BREAST CANCER
Authors: S. PREETHI , KUMAR HITESH , RAWAL VISHAL B. , AJMEER RAMKISHAN , JAIN VIKAS 
Published: March 2022

Anthraquinones are one of the popular classes of aromatic compounds which possess potential anticancer properties by suppressing the nucleic acid formation and proteins essential to the survival of cancerous cells. Mitoxantrone (MT) is an antibiotic and antineoplastic agent belonging to the anthracycline class of compounds which exhibit minimal incident of drug resistance. It is a synthetic anticancer drug, bound to enzyme topoisomerase IIα inhibitor, and intercalates DNA topoisomerase IIα, preventing re-ligations in DNA strands fragmentation and disruption of DNA repair. The expression of this enzyme was used tumor cells marker because of its key function in cell proliferation. The cleavable complex of topoisomerase IIα is hypothesized to damage the DNA and may enhance apoptosis in tumor cell proliferation. The susceptibility of cells to mitoxantrone is associated with cell topoisomerase II α protein and lowered resistance in breast cancer line cell lines to topoisomerase IIα inhibitors. MT is an ABC-transporter in breast cancer, also designated to be associated with “Breast cancer resistance protein” (BCRP) and it is also a cell cycle non-specific anti-cancer drug and P-glycoprotein substrate. Multiple drug resistance is one of the major drawbacks of this drug which can be avoided by reducing the efflux of the drug from cancer cells by formulating drug by using lipophilic carriers. This manuscript discusses about MT's source, chemistry, physicochemical properties, anti-cancer effects of mitoxantrone and possible pathways, Mitoxantrone targeting topoisomerase II inhibitor for cancer therapy and its mechanism, Various Nano formulation development strategy, toxicity profile, and a few patents related information.
SPECTROPHOTOMETRIC METHODS FOR THE QUANTITATIVE DETERMINATION OF MEMANTINE HYDROCHLORIDE IN PURE FORM AND PHARMACEUTICAL FORMULATIONS
Authors: AMIN ALI H. , EL SHEIKH RAGAA , ABDEL FATTAH GHADA M. , ALI MOHAMMED , ABDELNABY BASMA M. , GOUDA AYMAN A. 
Published: March 2022

Objective: Three simple, sensitive, accurate, and precise spectrophotometric methods have been developed and validated for the determination of Alzheimer’s disease drug memantine HCl (MEM) in pure form and pharmaceutical formulations.
Methods: The method was based on the formation of charge transfer complex between MEM as n-electron donor and various π-acceptors quinalizarin (Quinz) in methanol, p-chloranilic acid (p-CA) and 7,7,8,8-tetracyanoquinodimethane (TCNQ) in acetonitrile as chromogenic reagents which showed an absorption maximum at 558, 532 and 840 nm using Quinz, p-CA and TCNQ, respectively. The optimization of the reaction conditions such as the type of solvent, reagent concentration and reaction time were investigated.
Results: Under the optimum conditions, beer’s law is obeyed in the concentration ranges 4.0–24, 10–160 and 5.0–50 μg/mlusing Quinz, p-CA and TCNQ, respectively with good correlation coefficient (r2 ≥ 0.9995) and with a relative standard deviation (RSD% ≤ 1.11). For more accurate analysis, Ringbom optimum concentration ranges were found to be between 8.0–20, 15–140 and 10–45 μg/ml using Quinz, p-CA and TCNQ, respectively. The limits of detection were found to be 1.2, 2.70 and 1.45 µg/ml and the limits of quantification were found to be 4.0, 9.0 and 4.83 µg/ml for Quinz, p-CA and TCNQ, respectively. A Job's plot of the absorbance versus the molar ratio of MEM to each of the acceptors under consideration indicated (1:1) ratio.
Conclusion: The methods were successfully applied to the determination of MEM in its pharmaceutical formulations and the validity assessed by applying the standard addition technique. Results obtained by the proposed methods for the pure MEM and commercial tablets agreed well with those obtained by the reported method.
Analysis of Production Scheduling In “Abadi” Malang Rackets And Sport Equipment Company
Authors: Septiana Erika Fera , Asfiah Nurul , Roz Kenny 
Published: March 2022

Racket and Sports Equipment Company "Abadi" Malang is engaged in manufacturing. As a result of the covid-19, the company only produces midangan. The purpose of this research is to find out and find the optimal scheduling method so that it can overcome the problem of delays in order completion. The method used is the priority rule consisting of first come first serve (FCFS), shortest processing time (SPT), longest processing time (LPT), and earliest due date (EDD). The results of the study indicate that the SPT method is a method that has the most optimal measure of effectiveness compared to the FCFS, LPT, and EDD methods. The SPT method produces an average value of 21 days of completion, 31.74% utility, an average number of jobs in the system 3.15 jobs, and a delay of 12.5 days.
PEMBINAAN HOME MARKETING MODEL BERBASIS ONLINE BAGI KELOMPOK PENGRAJIN SONGKET DALAM UPAYA KETAHANAN EKONOMI DAN KEBERDAYAAN KELUARGA DI DESA BURAI OGAN ILIR
Authors: Waty Evy Ratna Kartika , Shomedran Shomedran , Nengsih Yanti Karmila , Nurrizalia Mega 
Published: March 2022

Kegiatan pengabdian kepada masyarakat ini merupakan kegiatan yang mendukung Program Perguruan Tinggi untuk berpartisipasi dan bagian pengabdian kepada masyarakat dalam usaha mencegah kekerasan pada anak melalui kegiatan penyuluhan dan pemberdayaan bagi masyarakat. Di sisi lain juga untuk menyebarkanluaskan informasi pada masyarakat dan keluarga, sebagai bagian anggota masyarakat, mengenai peran aktif mereka dalam upaya pencegahan terjadinya kekerasan pada anak. Kegiatan pengabdian ini dilakukan dengan metode ceramah, tanya jawab, diskusi dan pemecahan masalah suatu kasus dengan pelaksanaan melalui daring. Adapun peserta atau sasaran kegiatan adalah orangtua baik ibu-ibu rumah tangga yang sudah berkeluarga dan mempunyai anak yang berada di Desa Rahma Lubuk Linggau yang berjumlah sebanyak 16 orang. Kegiatan ini dilaksanakan pada hari Sabtu tanggal 15 Agustus 2020, hal pertama yang dilakukan adalah pemberian pre test, dilanjutkan pemaparan materi tentang keekrasan pada anak, faktor-faktor terjadinya kekerasan pada anak dan dampak dari adanya kekerasan pada anak dengan menggunakan metode ceramah dan tanya jawab dan ditutup dengan evaluasi kegiatan. Kegiatan pengabdian ini dapat dikatakan terlaksana dengan baik dan lancar, meskipun tidak terlepas dari beberapa hambatan dan keterbatasan dalam pelaksanaan kegiatan tertutama masa pandemi saat ini. Peserta cukup antusias dan bersemangat dalam mengikuti kegiatan, baik dalam menyimak pemaparan materi, tanya jawab dan diskusi. Hasil dari kegiatan ini menunjukkan presentase pemahaman peserta yang meningkat sebelum kegiatan dan sesudah kegiatan dengan dilakukan evaluasi melalui post test oleh tim pelaksana kegiatan.
Pengaruh Budaya Organisasi, Modal Intelektual, dan Perilaku Inovatif Terhadap Kinerja Pemimpin Jurusan di Universitas Negeri Medan
Authors: Purba Sukarman 
Published: March 2022

The Â objective Â of Â this Â research Â is Â to Â obtain Â information Â concerning Â the Â effect of Â organizationalÂ culture, Â intellectual Â capital, Â innovative Â behavior, Â on Department Â chairmanâ€™s Â performance. Â TheÂ research Â was Â carried Â out Â in Â 2005 with Â sample Â of Â 40, Â selected Â randomly Â and the data Â has Â beenÂ analyzed by path Â analysis Â after Â all Â variables Â put Â into Â the Â correlation Â matrix. Â Â The finding of Â theÂ research Â shows Â that Â Department Â chairmanâ€™s Â performance Â is Â affected directly by OrganizationalÂ culture, Intellectual capital, and Innovative behavior. Based on those findings it could be concluded thatÂ any changing or variation which occurred at Department chairmanâ€™s performance might have been effectedÂ by Organizational Â culture, Â Intellectual Â capital, Â and Â Innovative Â behavior. Therefore, Â in Â managingÂ Department chairmanâ€™s performance, organizational culture, intellectual capital, and innovativeÂ behavior should be put into strategic planning of human resources development at UniversitasÂ Negeri Â Medan, Â however other Â variables Â are Â necessary Â to Â be Â taken Â into Â account Â by Â next Â performance Â Â research.
ANALYSIS OF ACHIEVEMENT OF STUDENT SCIENCE PROCESS SKILLS THROUGH SAINTIFIC-BASED LKPD USING VIDEO CASE MEDIA IN IMPULS AND MOMENTUM MATERIALS
Authors: Sinuraya Jurubahasa , Umayak Lilis 
Published: March 2022

The purpose of the study was to analyze the achievement of science process skills of students through scientific-based LKPD using video case media on material. This type of research is experimental research. The research subjects were class X MIA in Madrasah Aliyah Negeri 1 Medan class X MIA 4. The research instrument used was a science process skills assessment sheet. Data analysis techniques using normalized N-gain equations to determine the achievement of students' science process skills. The results of research on the achievement of science process skills of students through scientific based LKPD using video case media on momentum material with an average percentage of mastery of PPP in LKPD is 78.9%. The LKPD that is used is quite effective to improve the mastery of science process skills of students who are characterized by a nationalized average N-Gain score which is 0.54 which has a medium criteria.
Estimasi Tingkat Aktivasi Virus COVID-19 dengan Menggunakan Metode Kalman Filter (Studi Kasus: di Provinsi Jawa Timur)
Authors: Asfihani Tahiyatul , Agustina Choiriyah Sapta , Hazmi Ahmad Ulul 
Published: March 2022

Abstract
COVID-19 is a concern in several countries because the rate of spread is fast enough to cause many deaths. COVID-19 is a disease caused by SARS-Cov-2. In this study, the SARS-Cov-2 activation rate was estimated using the Kalman Filter. The SARS-Cov-2 activation rate is the rate of change of the exposed class (Exposed) who completed the incubation period into the infected class (Infected). The spread of the COVID-19 disease was approached by the SEIR mathematical model. The SARS-Cov-2 activation rate is a parameter of SEIR's mathematical model of COVID-19 spread. The simulation results show that the SARS-Cov-2 activation rate in East Java in October 2021 is 0.563. The RMSE value that indicates the level of accuracy of the estimation process is 0,08.
Keywords: COVID-19, Parameter Estimation, Kalman Filter, East Java

Abstrak
COVID-19 menjadi perhatian di beberapa negara karena tingkat penyebarannya cukup cepat hingga mengakibatkan banyak kematian. COVID-19 merupakan penyakit yang disebabkan oleh virus SARS-Cov-2. Pada penelitian ini, tingkat aktivasi SARS-Cov-2 diestimasi menggunakan Kalman Filter. Tingkat aktivasi SARS-Cov-2 adalah tingkat perubahan individu terpapar (Exposed) yang selesai masa inkubasi dan masuk ke dalam kelas yang terinfeksi (Infected). Penyebaran penyakit COVID-19 didekati dengan model matematika SEIR. Tingkat aktivasi SARS-Cov-2 merupakan parameter dari model matematika penyebaran COVID-19 SEIR. Hasil simulasi menunjukkan bahwa tingkat aktivasi SARS-Cov-2 di Jawa Timur pada Oktober 2021 bernilai 0,563. Tingkat keakuratan proses estimasi ditunjukkan melalui nilai RMSE sebesar 0,08.
Kata Kunci: COVID-19, Estimasi Parameter, Kalman Filter, Provinsi Jawa Timur.
Jezus jako Sługa Jahwe w interpretacji Ewangelii św. Mateusza
Authors: Bernach Mariola 
Published: March 2022

Kontekstem badań była próba porównania starotestamentalnego terminu „Sługa Jahwe” z obrazem Jezusa w Ewangelii św. Mateusza. Zastosowano metody: krytyczno-literacką oraz porównawczą. W wyniku przeprowadzonych badań stwierdzono, że obraz Jezusa zamieszczony w Ewangelii św. Mateusza koreluje z obrazem Sługi Jahwe w Księdze Izajasza. Wnioski, jakie zostały wyciągnięte, sprowadzają się do tego, że Mateusz inspirował się Starym Testamentem, aby opisać Jezusa w swojej Ewangelii.
The consequence of workplace incivility among IT employees: Workplace stress or organizational citizenship behavior?
Authors: Annalakshmi Narayanan , Roshni Philip , Abhirami Sanjay , Udita Pant 
Published: March 2022

The impact of the work environment on employees has been well researched, with little focus on the pathways of such relationships. This study aimed to examine whether workplace incivility and personality predict workplace stress and organizational citizenship behavior (OCB). The role of John Henryism (JH), Probabilistic Orientation (PO), work self-efficacy, and resilience on workplace stress and OCB was also explored. The data were collected through a survey using self-report measures of perception of fair interpersonal treatment in the workplace, workplace incivility, work self-efficacy, JH, PO, workplace stress, and OCB from 206 (M=120, F=86) employees from the IT industry, aged 22 to 42 (M=30.47, SD=5.60). Multiple regression analyses revealed that workplace incivility (from supervisor and client) positively predicted workplace stress. At the same time, coworker incivility did not predict workplace stress. On the contrary, workplace incivility (supervisor, coworker, and clients) did not predict OCB significantly. JH and work self-efficacy positively predicted OCB, while PO negatively predicted OCB. This research provides new directions for future research that workplace stress is predicted by supervisor and client incivility, and OCB is not predicted by workplace incivility.
Distance Learning Methods in Learning in Vocational High Schools
Authors: Prasetyo Wati Andy , Handayani Sri , Martha Jefry Aulia , Zanky Mokhammad Nurruddi 
Published: March 2022

This research aims to find out how to optimize the use of distance learning methods in supporting students' cognitive abilities to continue optimal during self-learning at home. So, to answer the problem, researchers will use two indicator instruments, is distance learning to cognitive students and technological pedagogical content knowledge (TPACK) to the cognitive students. While the method used in this study is a survey method because there needs to be testing and proving how to distance learning and technological pedagogical content knowledge (TPACK). The dependent variables to the study are cognitive students (SC) and the independent variables are distance learning (DL) and technological pedagogical content knowledge (TPACK). There to answer the problem requires comprehensive data collection. This study used a saturated sampling of about 197 teachers obtained from SMK Pawyatan Daha 1 Kediri, SMK PGRI 2 Kediri, and SMKN 1 Bondowoso. Determination of population sampling and samples used in this study because the three places have implemented technology-based distance learning that using virtual meeting media (google classroom, zoom or google meet) and non-virtual meeting media (WhatsApp, telegram, youtube, etc.) as a balanced complement in the face of self-study policies by students. Data collection was conducted from June to October 2020 by adopting an online questionnaire. The results of theoretical and statistical studies concluded that distance learning was carried out in all three vocational high schools (SMK Pawyatan Daha 1 Kediri, SMK PGRI 2 Kediri, and SMKN 1 Bondowoso). Able to affect the cognitive abilities of students, especially when combined with the ability of teachers in master technology, content, and classes. Therefore, the two components should not be separated in supporting the success of distance learning, so that the achievement of goals in improving cognitive students can be done optimally.
Long-Term Complete Response of Advanced Lung Squamous Cell Carcinoma in an Elderly Patient Treated with First-Line Anti-PD-1 Antibody Monotherapy: A Case Report
Authors: Pan Xue , Xing Yufei , Yang Wenhong , Shi Minhua 
Published: March 2022

ABSTRACT

Introduction and importance:
Lung cancer is extremely difficult to treat due to its high incidence and mortality rate. Immune checkpoint inhibitor therapy is a major breakthrough in the field of oncology and is an emerging anti-tumor treatment modality after chemotherapy, targeted therapy and anti-angiogenic therapy. However, patients with complete response were also noticed as an anecdote especially in the aged. Here we presented a non-small cell lung cancer case who benefited from treatment of anti-PD-1 antibody.

Case presentation:
An 80-year-old male was admitted, presenting with a intermittent cough and a small amount of blood in the sputum for 2 months, computed tomography showed a lesion in the right lung. Lung puncture biopsy results suggested lung squamous cell carcinoma. Wild-type epidermal growth factor receptor (EGFR) and anaplastic lymphoma kinase (ALK) were showed in the tumor tissue specimen. Anti-programmed death 1 (PD-1) antibody monotherapy was initiated for 13 cycles. After the first anti-PD-1 antibody treatment, cryotherapy was performed under tracheoscopy on the mucosal bulge of the right principal bronchus and the root of the right upper lobe bronchial neoplasm. Complete remission (CR) was confirmed via imaging before the 3rd cycle. Subsequent CT suggested stable disease conditions. The presence of CR was further confirmed through a Positron Emission Computed Tomography (PET)/CT test in the 13th cycle. The patient now experienced a long-term complete response of more than 4 years till now.

Clinical Discussion:
Lung cancer has the highest morbidity and mortality in China. Immune monotherapy has become the standard first-line treatment for patients with upregulated expression of programmed death-ligand 1 (PD-L1). The effect of immunotherapy is similar and equally safe in older and younger patients with lung cancer. Monotherapy has the potential to achieve rapid lesion regression in elderly lung cancer patients, and the presence of immunological memory in T lymphocytes may be responsible for long-term response of the tumor lesions.

Conclusion:
We reported a long-term complete response of advanced lung squamous cell carcinoma in aged treated with first-line anti-PD-1 antibody monotherapy. More studies are needed to evaluate the efficacy and safety of immune checkpoint inhibitors in the aged.

Highlights:
A Comparison of the Thermodynamic and Kinematic Features in Recent Blizzard and Near-Blizzard Events in Iowa
Authors: Power Jennifer L. , Market Patrick S. , Cogil Craig 
Published: March 2022

Abstract
The purpose of this research is to determine the validity of the subjective, anecdotal rule that four isobars present across Iowa during a wintertime, snow-bearing, extratropical cyclone is sufficient to create the winds that attend a blizzard (the “Four Isobar Rule”). Using data from the National Centers for Environmental Information's online Storm Event Database, we identified 15 cases of blizzards in Iowa over the course of 10 years (1999-2009 plus one event in 2010). Subjective analyses of mean sea level pressure for those 15 events revealed an 87% success rate of having four isobars present corresponding with the Blizzard events. Conversely, we also analyzed 23 Near-Blizzard events and discovered that approximately 74% did not have four isobars present. Clearly, there is overlap between these types of events. Composite meteorological fields of both case sets were completed using the North America Regional Reanalysis datasets. The composite results are generally consistent with other recent findings on Iowa blizzards. The surface low is often fairly deep (&lt;1000 hPa), occluded or nearly so, featuring a convergent, descending lower troposphere, with 850-hPa winds of 45 kt or greater, and a near-surface layer whose lapse rate is nearly dry adiabatic. The composites of storms in the Blizzard category are slightly weaker than in prior literature, but the composites of storms in the Near-Blizzard category fail to meet any of the criteria for a blizzard in the state of Iowa.
Cephalothin as a Carrier of 6-Mercaptopurine for Targeting Cancer Tissues
Authors: H. Mohammad Mohammad , J.Al-Karagully Haider 
Published: March 2022

A lower extracellular pH is one of the few well-documented physiological differences between tumour and normal tissues. On the other hand, elevated glutathione (GSH) level has been detected in many tumours compared with healthy surrounding tissues. The compound II: 3-(9H-purin-6-yl-thio) carbonothionyl methyl-8-oxo-7-(2-thiophen-2-yl) acetamido-5-thia-1-azabicyclo-4-octo-ene-carboxylic acid was a cephalothin derivative contain 6-mercaptopurine (6-MP). Compound II react with general base catalysis in slightly acidic pH or with sulfhydryl nucleophiles to release the chemotherapeutic drug 6-MP. The generation of compound II was accomplished following multistep reaction procedures. The structure of compound II and its intermediate was confirmed by their melting point, infrared spectroscopy, CHN and NMR analysis. The hydrolysis of compound II in aqueous buffer solution of pH 6 and in the presence of GSH at pH 7.4 was studied. The partition coefficient (PC) of compound II was also determined. Compound II has acceptable rate of hydrolysis at slightly acidic medium pH 6 (t1/2 = 56.34 min.) and 80% of compound II had been converted to 6-MP within 30 min in the presence of GSH. And the compound has acceptable stability at pH 7.4(t0.5=639.65 min.) and the rate of hydrolysis was effected by change the buffer concentration. This compound can selectively deliver 6-MP into the tumour tissues which have acidic pH or elevated GSH level. Compound II had an improved PC value of 12.23 compared to 1.22 for free drug 6-MP confirming higher lipophilicity.
Key words: 6-mercaptopurine, cancer, prodrug, targeting
Single Dose Antibiotic Prophylaxis in Outpatient Oral Surgery Comparative Study
Authors: Y. Alhamdani Fadia , Y.Alhamdani Faaiz 
Published: March 2022

It is clear that correct application of antibiotic prophylaxis can reduce the incidence of infection resulting from the bacterial inoculation in a variety of clinical situations; it cannot prevent all infections any more than it can eliminate all established infections. Optimum antibiotic prophylaxis depends on: rational selection of the drug(s), adequate concentrations of the drug in the tissues that are at risk, and attention to timing of administration. Moreover, the risk of infection in some situations does not outweigh the risks which attend the administration of even the safest antibiotic drug. The aim of this study was to compare between 2 prophylactic protocols in out patients undergoing oral surgical procedures. Thirty patients, selected from the attendants of oral surgery clinic in Al-Karamah Dental Center, were subjected to different oral surgical procedures under local anesthesia. These patients were given single dose antibiotic prophylaxis in 2 groups; 1st group were 15 patients given 1 million i.u. of procaine penicillin I.M. 30 minutes before oral surgery, 2nd group were 15 patients given 600mg clindamycin orally 1 hours before oral surgery. The maximum time for all procedures was 2 hours. There was no difference between procaine penicillin (1 million i.u.), and clindamycin (600mg), regimens concerning post operative infection in out patientâ€™s oral surgical procedures.
Key words: Antibiotic prophylaxis, outpatient oral surgery
Cytotoxic Assay of Nigella sativa Leaf Callus Extract (Thymol) on Hep-2 Cell Line Using ELISA Assay
Authors: S. Abdel Gany Zaynab , F. Mahdi Mayasaa 
Published: March 2022

Extract from cell culture of medicinal plant like Nigella sativa have been assessed for its cytotoxic properties. Thymol is likely responsible for the theraputic effects of Nigella sativa leaf callus extract. In this short study the inhibitory effect of Nigella sativa leaf callus extract (Thymol) has been studied on Human Lorgnx Epidrmoid Carcinoma (Hep-2) cell line during different exposure period of time (24, 48 and 72 hrs.) using different concentration of the extract (1000, 500, 400, 300, 200 and 100 Âµg/ml). The optical density of the Hep-2 cells has been readed on 492 nm wave length. Thymol â€“induced cytotoxicity was (500 Âµg/ml) which inhibit cell growing compared to the control and this ratio increased at the 48 hrs of exopsure and stopped at 72 hrs.
Key wards: Nigella sativa, callus extract, cell line, ELISA assay.