bluuebunny/crossref_metadata_2025_split huggingface dataset:
Multivariate Analysis of Evoked Responses during the Rubber Hand Illusion Suggests a Temporal Parcellation into Manipulation and Illusion-Specific Correlates
Authors: Sciortino Placido , Kayser Christoph 
Published: January 2022

AbstractThe neurophysiological processes reflecting body illusions such as the rubber hand remain debated. Previous studies investigating the neural responses evoked by the illusion-inducing stimulation have provided diverging reports as to when these responses reflect the illusory state of the artificial limb becoming embodied. One reason for these diverging reports may be that different studies contrasted different experimental conditions to isolate potential correlates of the illusion, but individual contrasts may reflect multiple facets of the adopted experimental paradigm and not just the illusory state. To resolve these controversies, we recorded EEG responses in human participants and combined multivariate (cross-)classification with multiple Illusion and non-Illusion conditions. These conditions were designed to probe for markers of the illusory state that generalize across the spatial arrangements of limbs or the specific nature of the control object (a rubber hand or participant’s real hand), hence which are independent of the precise experimental conditions used as contrast for the illusion. Our results reveal a parcellation of evoked responses into a temporal sequence of events. Around 125 and 275 ms following stimulus onset, the neurophysiological signals reliably differentiate the illusory state from non-Illusion epochs. These results consolidate previous work by demonstrating multiple neurophysiological correlates of the rubber hand illusion and illustrate how multivariate approaches can help pinpointing those that are independent of the precise experimental configuration used to induce the illusion.
Pengembangan Perangkat Pembelajaran Larutan Elektrolit Berbasis Model Argument-Driven Inquiry untuk Melatih Keterampilan Argumentasi Ilmiah Siswa SMA
Authors: Akili Abd. Wahid Rizaldi , Lukum Astin , Laliyo Lukman Abdul Rauf 
Published: January 2022

Penelitian ini bertujuan untuk menghasilkan perangkat pembelajaran materi larutan elektrolit dan larutan non elektrolit berbasis model pembelajaran Argument-Driven Inquiry yang valid untuk melatih keterampilan argumentasi ilmiah siswa SMA. Pengembangan perangkat pembelajaran menggunakan model 4D (Four D), yang meliputi tahap pendefinisian (define), perancangan (design), pengembangan (develop), serta tahap penyebaran (dissemination). Namun dalam pelaksanaannya, penelitian ini terbatas hanya sampai pada tahap develope. Instrumen pengumpulan data dalam penelitian ini adalah lembar validasi. Teknik analisis data menggunakan analisis deskriptif kualitatif. Temuan hasil penelitian, yaitu perangkat pembelajaran yang dikembangkan meliputi buku siswa, RPP, LKPD, video pembelajaran dan instrumen tes keterampilan argumentasi ilmiahÂ telah memiliki validitas dengan kategori sangat valid; Hasil penelitian telah menunjukkan bahwa perangkat pembelajaran materi larutan elektrolit dan non elektrolit berbasis model pembelajaran Argument-Driven Inquiry telah memenuhi syarat valid dari segi isi dan konstruk.
Pengembangan Cacing Kimia sebagai Media Pembelajaran Kimia Berbasis Android pada Materi Larutan
Authors: Muhibullah Muhammad , Zamhari Muhammad 
Published: January 2022

Penelitian ini bertujuan untuk mengetahui karakteristik, menilai kualitas produk sebagai media pembalajaran kimia secara mandiri, serta mengetahui respon siswa terhadap media pembelajaran kimia berbasis android pada materi larutan. Jenis penelitian ini adalah penelitian pengembangan dengan menggunakan model 4-D (Define, Design, Develop dan Disseminate), tetapi pada disseminate hanya dilakukan uji skala kecil. Pengumpulan data menggunakan lembar penilaian kualitas dan angket respon siswa. Media yang dikembangkan divalidasi oleh dosen ahli media dan ahli materi dan penilaian penggunaan oleh guru kimia dan siswa. Hasil uji validasi ahli materi didapat 93,75% dengan ketegori sangat baik, ahli media Â didapat 96,7% dengan kategori sangat baik. Penilaian dilakukan oleh lima orang guru kimia di sekolah negeri dan swasta di Yogyakarta. Respon siswa diambil dari 20 siswa di dua sekolah yang berbeda di Yogkarta. Hasil penilaian guru kimia didapat 81,34% dengan kualitas baik. Adapun respon siswa memberikan hasil sebanyak Â 84%. Hasil penilaian menunjukkan bahwa media pembelajaran cacing kimia memiliki kualitas baik dan efektif digunakan sebagai media pembelajaran kimia mandiri.
Pengembangan Novel Grafik Elektronik pada Materi Reaksi Radikal Bebas sebagai Media Suplemen Pembelajaran
Authors: Sabianto Fransiskus , Melati Husna Amalya , Muharini Rini 
Published: January 2022

This research was aimed to produce a valid electronic graphic novel on free radical reaction subject and to find out the studentâ€™s response to the developed product. This research employed Research Development (RD) method by using Thiagarajanâ€™s 4D model with modification, in which applied only three of four steps in 4D model.Â The developed product was validated by experts. The responses toward developed product were collected from the students of Chemistry Education FKIP Untan who have taken organic chemistry course.Â Data collection tools used were validation sheets and studentâ€™s response questionnaires on the developed product.Â The validationâ€™s result from the experts showed that the developed product was very proper in terms of content, presentation, linguistic, and graphic aspects with consecutive total scores of 94.0%, 95.0%, 89.0%, and 100,00% respectively. The results of the studentâ€™s responses in small group trials and in large group trials were of 82.5% with high category and of 83.2% with very high category, respectively.Â Thus, this electronic graphic novel on radical reaction has very good potential as a learning media to attract students to learn free radical reaction and its application in daily life.
Addressing Mistreatment of Providers by Patients and Family Members as a Patient Safety Event
Authors: Hatfield Marianne , Ciaburri Rebecca , Shaikh Henna , Wilkins Kirsten M. , Bjorkman Kurt , Goldenberg Matthew , McCollum Sarah , Shabanova Veronika , Weiss Pnina 
Published: January 2022

OBJECTIVE
Mistreatment of health care providers (HCPs) is associated with burnout and lower-quality patient care, but mistreatment by patients and family members is underreported. We hypothesized that an organizational strategy that includes training, safety incident reporting, and a response protocol would increase HCP knowledge, self-efficacy, and reporting of mistreatment.

METHODS
In this single-center, serial, cross-sectional study, we sent an anonymous survey to HCPs before and after the intervention at a 213-bed tertiary care university children’s hospital between 2018 and 2019. We used multivariable logistic regression to examine the effect of training on the outcomes of interest and whether this association was moderated by staff role.

RESULTS
We received 309 baseline surveys from 72 faculty, 191 nurses, and 46 residents, representing 39.1%, 27.1%, and 59.7%, respectively, of eligible HCPs. Verbal threats from patients or family members were reported by 214 (69.5%) HCPs. Offensive behavior was most commonly based on provider age (85, 28.5%), gender (85, 28.5%), ethnicity or race (55, 18.5%), and appearance (43, 14.6%) but varied by role. HCPs who received training had a higher odds of reporting knowledge, self-efficacy, and experiencing offensive behavior. Incident reporting of mistreatment increased threefold after the intervention.

CONCLUSIONS
We report an effective organizational approach to address mistreatment of HCPs by patients and family members. Our approach capitalizes on existing patient safety culture and systems that can be adopted by other institutions to address all forms of mistreatment, including those committed by other HCPs.
The role of TRPC6 calcium channels and P2 purinergic receptors in podocyte mechanical and metabolic sensing
Authors: Gyarmati Georgina , Toma Ildikó , Izuhara Audrey , Burford James L. , Shroff Urvi Nikhil , Papadouri Stella , Deepak Sachin , Peti-Peterdi János 
Published: January 2022

Abstract
Podocyte calcium (Ca2+) signaling plays important roles in the (patho)physiology of the glomerular filtration barrier. Overactivation of podocyte transient receptor potential canonical (TRPC) channels including TRPC6 and purinergic signaling via P2 receptors that are known mechanosensors can increase podocyte intracellular Ca2+ levels ([Ca2+]i) and cause cell injury, proteinuria and glomerular disease including in diabetes. However, important mechanistic details of the trigger and activation of these pathways in vivo in the intact glomerular environment are lacking. Here we show direct visual evidence that podocytes can sense mechanical overload (increased glomerular capillary pressure) and metabolic alterations (increased plasma glucose) via TRPC6 and purinergic receptors including P2Y2. Multiphoton microscopy of podocyte [Ca2+]i was performed in vivo using wild-type and TRPC6 or P2Y2 knockout (KO) mice expressing the calcium reporter GCaMP3/5 only in podocytes and in vitro using freshly dissected microperfused glomeruli. Single-nephron intra-glomerular capillary pressure elevations induced by obstructing the efferent arteriole lumen with laser-induced microthrombus in vivo and by a micropipette in vitro triggered >2-fold increases in podocyte [Ca2+]i. These responses were blocked in TRPC6 and P2Y2 KO mice. Acute elevations of plasma glucose caused >4-fold increases in podocyte [Ca2+]i that were abolished by pharmacological inhibition of TRPC6 or P2 receptors using SAR7334 or suramin treatment, respectively. This study established the role of Ca2+ signaling via TRPC6 channels and P2 receptors in mechanical and metabolic sensing of podocytes in vivo, which are promising therapeutic targets in conditions with high intra-glomerular capillary pressure and plasma glucose, such as diabetic and hypertensive nephropathy.
Battling Against COVID-19 Infodemic in Indonesia: A Sociocybernetics Perspective
Authors: Putri Lovira , Rafly Reno F. 
Published: January 2022

As Indonesians collectively fight against the COVID-19 pandemic, the nation is simultaneously combatting the rampant spread of misinformation related to COVID-19. This phenomenon is often referred to as an ‘infodemic,’ defined by the World Health Organization (WHO) as the mass spread of information, factual or nonfactual, during a disease outbreak. In this article, we employ the methods of sociocybernetics analysis to examine the COVID-19 infodemic in Indonesia. We divide this paper into two sections. In the first section, we lay out the current state of the problem in Indonesia -how misinformation has challenged the post-pandemic recovery and changed the dynamics of Indonesian society at all levels, ranging from individuals to the society as-a-whole. In the second section, we propose a model, based on the approach of sociocybernetics, by which we propose to assess this challenge not just as a single entity but as a continuous, looping process, from the conception to the impact it has caused at all levels (micro, meso, and macro) of society. Given the complexity of this issue, we propose to develop an awareness and the education of cybernetics or systems thinking across multiple sectors when dealing with the infodemic in Indonesia.
More Than Just an Academic Exercise
Authors: Welton Anajale , Cumings Mansfield Katherine 
Published: January 2022

Critical policy analysis (CPA) is a means by which to critique policy and promote agency, equity, and justice. However, most CPA scholars examine political discourse from a distance rather than actively participate in political processes. Meanwhile, there's a growing interest in community-engaged research whereby academics partner with community members in their research endeavors. In this article, we consider the value of conjoining the philosophies and processes behind both CPA and community-engaged research to create more powerful and meaningful research endeavors that potentially can lead to political action and policy change. For this article, we present a subset of data from a larger study that asked education policy scholars how critical policy analysis informs their work and what they consider to be key objectives of this approach. We focus on a subsection of participants who demonstrated how and what ways they consider community-engaged scholarship to be an essential component of CPA.
Changes in macular thickness post uncomplicated MSICS & phacoemulsification surgery
Authors: Anand Kartika , Dokania Ashutosh 
Published: January 2022

To evaluate changes in macular thickness via-a-vis visual acuity post uncomplicated manual small incision cataract surgery (MSICS) & phacoemulsification surgery Prospective clinical study on 160 patients of uncomplicated immature senile cataract, aged 40-70yrs, patients were randomised into two groups, MSICS & phacoemulsification, by simple 1:1 randomization, who underwent uncomplicated cataract surgery with posterior chamber intraocular lens (PCIOL). Post-operatively, the patients were evaluated for best corrected visual acuity (BCVA) and changes in macular thickness by optical coherence tomography (OCT) at post-op Day 1, 7, 21, 48, and 12 weeks. Paired t-test was used for comparison across follow up. : At 12 weeks post-operative, mean logMAR BCVA was 0.01±0.02 for MSICS group and 0±0.02 for Phacoemulsification group. Macular thickness was not statistically significant (p=0.342) between MSICS group (219.19±17.88µm) and Phacoemlusification group (215.61±16.21µm), at the end of 12 weeks post-operative. Clinically significant macular oedema was not diagnosed in any of the patients at the follow-ups.: Both procedures achieved good post-operative Best Corrected visual acuity without significant differences in BCVA between both the groups at the end of 12 weeks.
Clinical profiles of patients with optic neuritis and papillitis: A prospective study
Authors: Chaurasia I D , Chaurasia Yogita 
Published: January 2022

To analyse the demographics and presenting features of patients presenting with optic neuritis and papillitis. Clinical profiles of 40 patients presenting with optic neuritis and papillitis at a tertiary care center were collected retrospectively and prospectively. Detailed medical and ophthalmic history was taken especially about mode, duration and course of the disease, drug intake, alcoholism, smoking, pregnancy, lactation, convulsions, pyrexia, history suggestive of TB, syphilis, neurological deficit. A comprehensive ophthalmological and neurological evaluation was done for each patient along with radiological work up. Patients were prospectively followed up for an average of three months. Females in the reproductive age group constituted largest number of the patients (61.8%) in the present series. Maximum patients (70%) were between 20-50 years of age. Vision was found to be affected in all the patients at presentation and most of them presented with vision CF or HM (35.4% and 29.25% respectively) while 4 patients had complete loss of vision. Two third (66.7%) of patients reported eye pain at presentation. Abnormal pupillary reaction was found in most patients with the most common being RAPD on swinging flash light which was seen in 85.4%. Equal percentage (39.5%) of patients presented with Blurred Hyperemic (BH) disc and ophthalmoscopically normal appearing disc. Onset and progression of disease was found to be rapid in most cases ranging from few hours to days. Visual recovery post treatment was found to be good with most eyes achieving vision 6/24 or better. Optic neuritis has varied clinical presentations. Most of our patients were young to middle aged females. The most common presenting features were decrease in vision ranging from slight to profound, eye pain and abnormal pupillary reaction. Morphological abnormalities in appearance of optic disc were also found in two third of cases.Rapid progression was noted in almost all cases. Most of the cases achieved a good outcome at the end of follow up period.
Profile of ocular injuries amongst various trauma patients presenting to tertiary care centre of Punjab
Authors: Bhatti Anubha , Kakkar Arushi , Singh Shakeen 
Published: January 2022

To study the epidemiology and clinical profile of ocular trauma patients presenting to tertiary care centre. Prospective study. All patients of ocular trauma in OPD/Emergency were assessed for detail between 1/1/17 to 31/6/18 and data on demographic profile was established as per guidelines of Ocular Trauma Society of India. Patients were categorized in different segments and assessed/followed for visual impairment in particular. A total of 246 cases were examined out of which 87% were males. The most common mode of ocular injury was Road Traffic Accidents. Pediatric eye trauma constituted 16.7% of the total cases. 26.8% cases arrived to our centre between 4-24 hours and 62.6% cases presented after 24 hours. Amongst 131 cases of Road Traffic Accidents, none of them were using protective measures like helmets or goggles. Of these, 17.1% were under the influence of alcohol. 28.5% were involved in medicolegal proceedings. Majority of the cases comprised of monocular trauma (78.1%). Closed globe injuries constituted 88.94% of the total cases of which most cases presented with lid edema and ecchymosis. Chemical injuries were reported in 4.5% cases. 9 patients lost vision completely and 71 cases had vision from light perception to 6/18. Ocular trauma is one of the common causes of ocular morbidity. It has been seen predominantly in male population. Public needs to be educated about safety measurements and education about prompt need to specialised care to reduce ocular trauma related visual morbidity.
Slit lamp photography for objective assessment of topical eye disorders
Authors: Biradar A B , Das Arun , Adeeb A  
Published: January 2022

Evidence based scientific studies has weightage, when they are presented with quantitative data analysis. Documentation and parametric analysis has become an integral part of present day research. Any publications or write-ups without explanation through standard parameters are not appreciated by the research society. In Ophthalmology assessment of various parameters through photography is a debatable issue. Affordability for higher end diagnostic / OPD instruments may not be feasible for all. In such a scenario, here is an attempt made to standardize the slit lamp photography with a smart phone and its scientific analysis for evaluating clinical conditions like sub-conjunctival hemorrhage, etc. This technique can become a tool for assessment and response of the therapies as well as an important tool to seek help from higher centers. Various add-on benefits in research, limitation and scope for further evaluation also being discussed.
Visual outcomes and intraoperative complications of small incision cataract surgery performed by junior residents in GMC
Authors: Naik Vishaka , Usgaonkar Ugam P .S 
Published: January 2022

To evaluate in intraoperative complications of MSICS performed by Junior Residents and to compare the incidences of major complications in the first six months of training versus last six months of training.It is a retrospective type of study. From March 2018 to February 2019 a total of 293 manual SICS were conducted by the Junior Residents in Department of Ophthalmology. Each of the patients underwent a detailed ophthalmological examination preoperatively and underwent MSICS under peribulbar anesthesia. Consents for surgeries were obtained from each patient.Following intraoperative complications were noted: tunnel related complications, capsulorrhexis related complications, Iridodialysis, posterior capsular rent, zonular dialysis, vitreous leak, surgical aphakia, Descemet membrane detachment, placement of ACIOL, Nucleus drop and IOL drop. The patient’s immediate postoperative vision was also noted. SPSS version 15.0.Tunnel related complications were found in 13.98% patients either as scleral button holing or premature entry. Posterior capsular rents and bag disinsertion were found in total of 11.94% patients owing to which 3.07% were left aphakic. 63.13% patients had visual acuity better than 6/12 by snellens chart on first postoperative day. Performance of adequate anterior capsulotomy, minimal handling of the cornea and avoidance of posterior capsular rent are some of the challenges faced by the residents while learning MSICS. Stepwise supervised training can help a resident doctor master these steps while keeping the complications at acceptably low levels. Stepwise supervised training of residents performing MSICS can minimize complications
Pattern and risk factors of retinopathy of prematurity in tertiary care centre
Authors: Shende Snehal , Gour Richa , Melwani Veena , Singh Priti , Kumar Kavita 
Published: January 2022

Retinopathy of prematurity is one of the commonest cause of blindness in sick neonates exposed to excessive oxygen following NICU admissions. The present study was thus conducted to assess the pattern and risk factors associated with incidence of retinopathy of prematurity.A retrospective record based study was conducted at tertiary care centre between 1st July 2017 to 30thMay 2020 were screened for ROP. Baseline characteristics and risk factors for ROP were assessed. The zone and stage of ROP were categorized as per the International classification of ROP along with iris neovascularisation and plus disease as per the revised international classification of retinopathy of prematurity (ICROP) preplus disease criteria. Data was entered in excel sheet and analysed using SPSS software version 20.Majority of neonates belonged to gestational age of 28 to 31 weeks (58.8%) and 51.2% neonates had birthweight of 1.5 to 2 kg. Male preponderance was observed with male: female ratio of 1.75:1. Amongst the various risk factors, the occurrence of ROP was highly significantly associated with gestational age and birthweight (p&#60;0.01). Subgroup analysis revealed that aggressive posterior ROP (APROP) contributed significantly to Type I ROP in 11.1% (3) cases. And the observed difference in gestational age and birthweight between APROP and other cases of ROP were statistically highly significant (p&#60;0.01).Early and timely screening of ROP for all high risk neonates especially low birth weight and neonates with small gestational age should be mandatory as these are the most significant risk factors associated with ROP in present study.
Effect of heparin sodium on postoperative inflammation after adult cataract surgery
Authors: Ganekal Sunil , Dorairaj Syril , Ganekal Varun 
Published: January 2022

To evaluate the effect of use of ringer lactate solution supplemented with heparin sodium in patients undergoing cataract surgery.In a prospective, double-blind, interventional study, 200 patients were included and were randomized to undergo cataract surgery using ringer lactate solution with or without 10 IU/ml heparin. All patients underwent phacoemulsification with hydrophobic acrylic foldable intraocular lens (IOL) implantation. The severity of anterior chamber inflammation and amount of pigment deposition of IOL was assessed by slit lamp biomicroscopy on day 1, 7, 28 and after 8 weeks postoperatively. Mean age in treatment and control group was 63.0± 11.5 years and 65.1±12.7 years respectively. A significant reduction in the severity of inflammatory cellular activity (p=0.001), flare (p=0.001) and pigment deposition on IOL (p=0.001) was noted on day 1 in the heparin treated group compared to the control group. However, no significant difference was observed in the amount of inflammatory activity as well as IOL pigment deposition beyond 1 week postoperatively. The inflammatory activity resolved almost completely in both the groups by the end of 8 weeks postoperatively. : Our study showed the beneficial effect of addition of heparin to irrigating solution during cataract surgery. Heparin treated eyes demonstrated a reduction in the early postoperative inflammation and IOL pigment deposition. The anti-inflammatory effect was observed in the early postoperative period.