bluuebunny/crossref_metadata_2025_split huggingface dataset:
Population-based study of treatment and outcome of recurrent oesophageal or junctional cancer
Authors: Pape Marieke , Vissers Pauline A J , Bertwistle David , McDonald Laura , Beerepoot Laurens V , van Berge Henegouwen Mark I , Lagarde Sjoerd M , Mook Stella , Mohammad Nadia Haj , Jeene Paul M , van Laarhoven Hanneke W M , Verhoeven Rob H A 
Published: October 2022

Abstract

Background
Patients with cancer of the oesophagus or gastro-oesophageal junction have a high risk of recurrence after treatment with curative intent. The aim of this study was to analyse the site of recurrence, treatment, and survival in patients with recurrent disease.

Methods
Patients with non-metastatic oesophageal or junctional carcinoma treated with curative intent between January 2015 and December 2016 were selected from the Netherlands Cancer Registry. Data on recurrence were collected in the second half of 2019. Overall survival (OS) was assessed by Kaplan–Meier methods.

Results
In total, 862 of 1909 patients (45.2 per cent) for whom information on follow-up was available had disease recurrence, and 858 patients were included. Some 161 of 858 patients (18.8 per cent) had locoregional recurrence only, 415 (48.4 per cent) had distant recurrence only, and 282 (32.9 per cent) had combined locoregional and distant recurrence. In all, 518 of 858 patients (60.4 per cent) received best supportive care only and 315 (39.6 per cent) underwent tumour-directed therapy. Patients with locoregional recurrence alone more often received chemoradiotherapy than those with distant or combined locoregional and distant recurrence (19.3 per cent versus 0.7 and 2.8 per cent), and less often received systemic therapy (11.2 per cent versus 30.1 and 35.8 per cent). Median OS was 7.6, 4.2, and 3.3 months for patients with locoregional, distant, and combined locoregional and distant recurrence respectively (P &lt; 0.001).

Conclusion
Disease recurred after curative treatment in 45.2 per cent of patients. Locoregional recurrence developed in only 18.8 per cent. The vast majority of patients presented with distant or combined locoregional and distant recurrence, and received best supportive care.
Chromosome-level genome of a leaf vegetableGlebionis coronariaprovides insights into the biosynthesis of monoterpenoids contributing to its special aroma
Authors: Wang Sen , Wang Anqi , Wang Hengchao , Jiang Fan , Xu Dong , Fan Wei 
Published: October 2022

AbstractGlebionis coronaria is a popular vegetable with special aroma and a medical plant in East Asia and Mediterranean, but its biological studies and breeding have been hindered by the lack of reference genome. Here, we present a chromosome-level reference genome of G. coronaria, with assembled genome size of 6.8 Gb, which is the largest among all the published genomes of diploid Asteraceae species. The large genome size of G. coronaria is mainly caused by the recent widespread explosions of long-terminal-repeat retrotransposons. Analyses of macro-synteny and synonymous mutation rate distribution indicate that the G. coronaria genome experienced a whole-genome triplication at 40–45 million years ago, shared with all Asteraceae species. In subtribe Artemisiinae, Glebionis arose before the divergence of Chrysanthemum from Artemisia, and Glebionis species evolved much faster than Chrysanthemum and Artemisia species. In G. coronaria, the synthesis genes of monoterpenoids 8-oxocitronellyl enol and isopiperitenone were expanded, and the higher expressions of these expanded genes in leaves and stems may contribute to its special aroma. The G. coronaria genomic resources will promote the evolution studies of Asteraceae, the metabolism mechanism studies of bioactive compounds, and the breeding improvement of agronomic traits in G. coronaria.
First report of myocarditis in two patients with COVID-19 Omicron variant: case report
Authors: Fishman Boris , Goitein Orly , Berkovitch Anat , Rahav Galia , Matetzky Shlomi 
Published: October 2022

Abstract

Background
Severe acute respiratory syndrome coronavirus 2 infection is responsible for the coronavirus disease 2019 (COVID-19) pandemics. Omicron (B.1.1.529) variant is the cause for the surge of the COVID-19 pandemics of the end of 2021 and the beginning of 2022, although its subvariants are responsible for the following daily increase of COVID-19 cases in July 2022. Early reports of Omicron variant confirmed patients indicated less severe disease course compared with the disease caused by previously encountered variants with absence of data regarding cardiac involvement by Omicron.

Case summary
A 42-year-old male who tested positive for Omicron was admitted on January 2022 with chest pain and ST-segment elevation in the inferior leads. Coronary angiography revealed non-significant coronary artery disease. Cardiac magnetic resonance imaging demonstrated features consistent with myocarditis with involvement of 22% of the left ventricular mass by late gadolinium enhancement involving both the lateral and the septal walls. The second patient is a 60-year-old male presented following syncope and palpitations after he was confirmed with Omicron infection. Upon emergency department arrival he had ventricular tachycardia of 250 beats/minute and underwent urgent cardioversion. During his hospitalization, there was no recurrence of malignant arrhythmia, coronary angiography revealed non-obstructive disease. Cardiac magnetic resonance imaging demonstrated imaging features suggesting acute myocarditis with involvement of 19% of the left ventricular mass.

Discussion
This is the first report of myocarditis cases as a possible complication associated with Omicron variant. Despite preliminary reports of less severe disease clinicians should be vigilant for potential deleterious cardiac complications of Omicron.
The risk of cardiovascular diseases after miscarriage, stillbirth, and induced abortion: a systematic review and meta-analysis
Authors: Kyriacou Harry , Al-Mohammad Abdulrahman , Muehlschlegel Charlotte , Foster-Davies Lowri , Bruco Maria Eduarda Ferreira , Legard Chloe , Fisher Grace , Simmons-Jones Fiona , Oliver-Williams Clare 
Published: October 2022

Abstract

Aims
Miscarriage and stillbirth have been included in cardiovascular disease (CVD) risk guidelines, however heterogeneity in exposures and outcomes and the absence of reviews assessing induced abortion, prevented comprehensive assessment. We aimed to perform a systematic review and meta-analysis of the risk of cardiovascular diseases for women with prior pregnancy loss (miscarriage, stillbirth, and induced abortion).

Methods and results
Observational studies reporting risk of CVD, coronary heart disease (CHD), and stroke in women with pregnancy loss were selected after searching MEDLINE, Scopus, CINAHL, Web of Knowledge, and Cochrane Library (to January 2020). Data were extracted, and study quality were assessed using the Newcastle-Ottawa Scale. Pooled relative risk (RR) and 95% confidence intervals (CIs) were calculated using inverse variance weighted random-effects meta-analysis.
Twenty-two studies involving 4 337 683 women were identified. Seven studies were good quality, seven were fair and eight were poor. Recurrent miscarriage was associated with a higher CHD risk (RR = 1.37, 95% CI: 1.12–1.66). One or more stillbirths was associated with a higher CVD (RR = 1.41, 95% CI: 1.09–1.82), CHD (RR = 1.51, 95% CI: 1.04–1.29), and stroke risk (RR = 1.33, 95% CI: 1.03–1.71). Recurrent stillbirth was associated with a higher CHD risk (RR = 1.28, 95% CI: 1.18–1.39). One or more abortions was associated with a higher CVD (RR = 1.04, 95% CI: 1.02–1.07), as was recurrent abortion (RR = 1.09, 95% CI: 1.05–1.13).

Conclusion
Women with previous pregnancy loss are at a higher CVD, CHD, and stroke risk. Early identification and risk factor management is recommended. Further research is needed to understand CVD risk after abortion.
Optimization of anti-tachycardia pacing efficacy through scar-specific delivery and minimization of re-initiation: a virtual study on a cohort of infarcted porcine hearts
Authors: Qian Shuang , Connolly Adam , Mendonca-Costa Caroline , Campos Fernando , Rodero Cristobal , Whitaker John , Rinaldi Christopher A , Bishop Martin J 
Published: October 2022

AbstractAimsAnti-tachycardia pacing (ATP) is a reliable electrotherapy to painlessly terminate ventricular tachycardia (VT). However, ATP is often ineffective, particularly for fast VTs. The efficacy may be enhanced by optimized delivery closer to the re-entrant circuit driving the VT. This study aims to compare ATP efficacy for different delivery locations with respect to the re-entrant circuit, and further optimize ATP by minimizing failure through re-initiation.Methods and resultsSeventy-three sustained VTs were induced in a cohort of seven infarcted porcine ventricular computational models, largely dominated by a single re-entrant pathway. The efficacy of burst ATP delivered from three locations proximal to the re-entrant circuit (septum) and three distal locations (lateral/posterior left ventricle) was compared. Re-initiation episodes were used to develop an algorithm utilizing correlations between successive sensed electrogram morphologies to automatically truncate ATP pulse delivery. Anti-tachycardia pacing was more efficacious at terminating slow compared with fast VTs (65 vs. 46%, P = 0.000039). A separate analysis of slow VTs showed that the efficacy was significantly higher when delivered from distal compared with proximal locations (distal 72%, proximal 59%), being reversed for fast VTs (distal 41%, proximal 51%). Application of our early termination detection algorithm (ETDA) accurately detected VT termination in 79% of re-initiated cases, improving the overall efficacy for proximal delivery with delivery inside the critical isthmus (CI) itself being overall most effective.ConclusionAnti-tachycardia pacing delivery proximal to the re-entrant circuit is more effective at terminating fast VTs, but less so slow VTs, due to frequent re-initiation. Attenuating re-initiation, through ETDA, increases the efficacy of delivery within the CI for all VTs.
Prognostic value of right ventricular refractory period heterogeneity in Type-1 Brugada electrocardiographic pattern
Authors: Rossi Andrea , Giannoni Alberto , Nesti Martina , Notarstefano Pasquale , Castiglione Vincenzo , Solarino Gianluca , Teresi Lucio , Mirizzi Gianluca , Russo Vincenzo , Panchetti Luca , Startari Umberto , Ripoli Andrea , Gentile Francesco , Santoro Amato , Botto Nicoletta , Casolo Giancarlo , Sieira Juan , Pieroni Maurizio , Santangeli Pasquale , Emdin Michele , Piacenti Marcello 
Published: October 2022

AbstractAimsTo investigate the prognostic significance of heterogeneity in the refractoriness of right ventricular (RV) outflow tract (RVOT) and RV apex at the electrophysiological study (EPS) in Brugada syndrome (BrS).Methods and resultsA cohort of BrS patients (primary prevention) from five Italian centres was retrospectively analysed. Patients with spontaneous or drug-induced Type-1 electrocardiogram (ECG) + symptoms were offered an EPS for prognostic stratification. The primary endpoint was a composite of sudden cardiac death (SCD), resuscitated cardiac arrest, or appropriate intervention by the implantable cardioverter-defibrillator (ICD). Three hundred and seventy-two patients with BrS were evaluated (44 ± 15 years, 69% males, 23% with ICD): 4 SCDs and 17 ICD interventions occurred at follow-up (median 48, interquartile range: 36–60 months). Family history of SCD, syncope, and a spontaneous Type-1 ECG pattern were univariate predictors of the primary endpoint in the whole population. In patients undergoing EPS (n = 198, 53%, 44 ± 12 years, 71% males, 39% with ICD), 3 SCD and 15 ICD interventions occurred at follow-up. In this subset, the primary endpoint was not only predicted by ventricular tachycardia/fibrillation inducibility but also by a difference in the refractory period between RVOT and RV apex (ΔRPRVOT-apex) &gt;60 ms. ΔRPRVOT-apex &gt; 60 ms remained an independent predictor of SCD/ICD shock at bivariate analysis, even when adjusted for the other univariate predictors, showing the highest predictive power at C-statistic analysis (0.75, 95% confidence interval 0.63–0.86).ConclusionsHeterogeneity of RV refractory periods is a strong, independent predictor of life-threatening arrhythmias in BrS patients, beyond VT/VF inducibility at EPS and common clinical predictors.
A niching particle swarm optimization strategy for the multimodal inversion of surface waves
Authors: Zhang Kai , Li Hongyi , Wang Kai , Liu Min , Cai Wei , Liu Dongming 
Published: October 2022

SUMMARY
In practice, near-surface structures with shear wave velocity inversions or strong shear wave velocity contrasts may cause the phase velocity spectra of surface waves to be complex. Hence, it is sometimes difficult to identify mode numbers in the phase velocity spectrum. To avoid numbering different modes, the determinant misfit function has been applied to invert multimodal dispersion curves with a very limited computational cost due to the absence of the root-seeking procedure. However, this function presents a complicated relation with modal parameters and thus has multiple minima, resulting in an increase in model ambiguity. Therefore, it is more appropriate to adopt a multimodal optimization algorithm to find multiple minima instead of obtaining one optimal solution. In this study, we use a niching particle swarm optimization to find multiple minima with an enhanced fine search ability. Subsequently, we performed cluster analysis to distinguish different clusters in the inverted solutions and find the best-fitting profiles from multiple minima based on the Euclidean distance between the measured and inverted dispersion curves. Moreover, a modified Thomson–Haskell transfer matrix method is used to calculate the determinant misfit function for a better constraint on inversion because it can only resolve the surface wave modes possessing energy at the free surface, where both the sources and geophones are commonly deployed for active and passive surface wave exploration. Tests of synthetic and field data demonstrate that our inversion method is both effective and robust and emphasize its great potential in urban subsurface exploration and geotechnical characterization applications.
The importance of side branches of glycosylphosphatidylinositol anchors: a molecular dynamics perspective
Authors: Banerjee Pallavi , Silva Daniel Varon , Lipowsky Reinhard , Santer Mark 
Published: October 2022

Abstract
Many proteins are anchored to the cell surface of eukaryotes using a unique family of glycolipids called glycosylphosphatidylinositol (GPI) anchors. These glycolipids also exist without a covalently bound protein, in particular on the cell surfaces of protozoan parasites where they are densely populated. GPIs and GPI-anchored proteins participate in multiple cellular processes such as signal transduction, cell adhesion, protein trafficking and pathogenesis of Malaria, Toxoplasmosis, Trypanosomiasis and prion diseases, among others. All GPIs share a common conserved glycan core modified in a cell-dependent manner with additional side glycans or phosphoethanolamine residues. Here, we use atomistic molecular dynamic simulations and perform a systematic study to evaluate the structural properties of GPIs with different side chains inserted in lipid bilayers. Our results show a flop-down orientation of GPIs with respect to the membrane surface and the presentation of the side chain residues to the solvent. This finding agrees well with experiments showing the role of the side residues as active epitopes for recognition of GPIs by macrophages and induction of GPI-glycan-specific immune responses. Protein-GPI interactions were investigated by attaching parasitic GPIs to Green Fluorescent Protein. GPIs are observed to recline on the membrane surface and pull down the attached protein close to the membrane facilitating mutual contacts between protein, GPI and the lipid bilayer. This model is efficient in evaluating the interaction of GPIs and GPI-anchored proteins with membranes and can be extended to study other parasitic GPIs and proteins and develop GPI-based immunoprophylaxis to treat infectious diseases.
Stable isotopes reveal that bottom-up omnivory drives food chain length and trophic position in eutrophic coastal ecosystems
Authors: Lerner Jacob E , Marchese Christian , Hunt Brian P V 
Published: October 2022

Abstract
In coastal marine food webs, food chain length and the distribution of trophic levels mediate the impacts of emerging threats such as overfishing, pollution, and climate change, through their effect on essential properties such as productivity, connectivity, and energy transfer efficiency. These two components of food web structure are therefore an essential element of ecosystem-based management; however, what drives them remains poorly understood. It has been hypothesized that high primary production drives lower trophic levels and shorter food chain length in coastal regions. Here, we evaluate this hypothesis on the British Columbia (BC) coast as this coastal marine ecosystem is comprised of regions with contrasting levels of primary production. We measured nitrogen stable isotopes from zooplankton, micronekton, and nekton collected from four of the main water bodies of southern BC during a survey completed in August of 2019. We used Sentinel-3 satellite data to determine overall production in each region across a 5-year climatology and during the 2019 season. Results showed that primary production varied significantly between the four regions and that increases in phytoplankton biomass were driven by increases in microphytoplankton. Nitrogen isotope data demonstrated a significant inverse relationship between a region’s primary production and both total food chain length and trophic level in species sampled in multiple regions, but no change in the trophic structure of the zooplankton community across regions. Changes in species’ trophic levels were therefore driven by shifts in the level of zooplanktivory. These results support a model of bottom-up omnivory driving coastal food web structure, where levels of primary production, specifically biomass of microphytoplankton, determine food chain length and the distribution of trophic levels. High microphytoplankton biomass supports a large biomass of large grazing zooplankton, which drive increases in omnivorous feeding behaviour among the micronekton and nekton.
Primary Anal Cancer Screening Results From 381 Women With Human Immunodeficiency Virus
Authors: Liu Yuxin , Weiss Kevin , Zamudio Andrés Ramírez , Hayes Monica Prasad , Saleh Mona , Gaisa Michael M , Sigel Keith 
Published: October 2022

Abstract

Background
Women with human immunodeficiency virus (WWH) have an elevated risk for human papillomavirus (HPV)-associated anal cancer. Primary anal cancer screening results from this population could inform practice guidelines.

Methods
In total, 381 WWH with anal cytology screening, high-risk HPV (hrHPV) testing and genital (cervical or vaginal) cotesting within 6 months were identified during 2012–2019. Those with anal cytology of atypical squamous cells of undetermined significance (ASCUS) or worse underwent high-resolution anoscopy and biopsy. Independent predictors of anal hrHPV, HPV16, and histological anal high-grade squamous intraepithelial lesions (aHSIL) were identified using adjusted logistic regression models.

Results
Prevalence of anal hrHPV, HPV16, and ASCUS or worse cytology was 61%, 13%, and 68%. Histological aHSIL was detected in 42% of WWH with ASCUS or worse anal cytology. Prevalence of genital hrHPV, HPV16, and ASCUS or worse cytology was 30%, 4%, and 28%. Genital hrHPV predicted anal hrHPV (odds ratio [OR], 5.05), while genital HPV16 predicted anal HPV16 (OR, 9.52). Genital hrHPV and anal HPV16 predicted histological aHSIL (ORs, 2.78 and 10.9).

Conclusions
Anal HPV disease was highly prevalent in this primary screening cohort of WWH. While genital screening results predicted anal disease, rates of isolated anal HPV disease were substantial, supporting universal anal cancer screening for this population.
A regional approach to reduce postoperative opioid prescribing in Ontario, Canada
Authors: Jackson Timothy D , Maeda Azusa , Beath Tricia , Ahmad Nancy , Price-arsenault Pierrette , Jia Hui , Lam Jonathan , Schramm David 
Published: October 2022

Abstract
Background: Opioid-related morbidity and mortality continue to rise in the province of Ontario. We implemented a provincial campaign to reduce the number of opioid pills prescribed at discharge after surgery in the Ontario Surgical Quality Improvement Network (ON-SQIN).
Methods: Activities related to the provincial campaign were implemented between April 2019 and March 2020 and between October 2020 and March 2021. Self-reported data from participating hospitals were used to determine changes in postoperative opioid prescribing patterns across participating hospitals.
Results: A total of 33 and 26 hospitals participated in the provincial campaign in the first and second year, respectively. During the first year of the campaign, the median morphine equivalent (MEQ) from opioid prescriptions decreased significantly in a number of surgical specialties, including General Surgery (from 105 [75–130] to 75 [55–107], P &lt; 0.001) (median, interquartile range) and Orthopedic Surgery (from 450 [239–600] to 334 [167–435], P &lt; 0.001). The median number of opioid pills prescribed at discharge per surgery also decreased significantly, from 25 (15–53) to 15 (11–38) for 1 mg hydromorphone (P &lt; 0.001) and 25 (20–51) to 20 (15–30) for oxycodone (P &lt; 0.001). The decrease in opioid prescriptions continued in the second year of the campaign.
Conclusions: Our approach resulted in a significant reduction in the number of postoperative opioids prescribed across a number of surgical specialties. Our findings indicate that evidence-based strategies derived from a regional collaborative network can be leveraged to promote and sustain quality improvement activities.
Taxonomic boundaries in Lesser Treeshrews (Scandentia, Tupaiidae: Tupaia minor)
Authors: Juman Maya M , Woodman Neal , Miller-Murthy Ananth , Olson Link E , Sargis Eric J 
Published: October 2022

Abstract
The Lesser Treeshrew, Tupaia minorGünther, 1876, is a small mammal from Southeast Asia with four currently recognized subspecies: T. m. minor from Borneo; T. m. malaccana from the Malay Peninsula; T. m. humeralis from Sumatra; and T. m. sincepis from Singkep Island and Lingga Island. A fifth subspecies, T. m. caedis, was previously synonymized with T. m. minor; it was thought to occur in northern Borneo and on the nearby islands of Banggi and Balambangan. These subspecies were originally differentiated based on pelage color, a plastic feature that has proven to be an unreliable indicator of taxonomic boundaries in treeshrews and other mammals. To explore infraspecific variation among T. minor populations across the Malay Peninsula, Borneo, Sumatra, and smaller islands, we conducted multivariate analyses of morphometric data collected from the hands and skulls of museum specimens. Principal component and discriminant function analyses reveal limited differentiation in manus and skull proportions among populations of T. minor from different islands. We find no morphometric support for the recognition of the four allopatric subspecies and no support for the recognition of T. m. caedis as a separate subspecies on Borneo.