bluuebunny/crossref_metadata_2025_split huggingface dataset:
Biomechanical Evaluation of a Low-Invasive Elbow Medial Collateral Ligament Reconstruction Technique With Fascia and Tendon Patches
Authors: Liu Wenjun , Xiong Hao , Chen Shuai , Zhang Jingwei , Wang Wei , Qian Yun , Fan Cunyi 
Published: March 2022

Background: Injury to the medial collateral ligament (MCL) of the elbow has become increasingly common in sports, and the elbow is prone to contracture and ossification in trauma. Effective reconstruction of the MCL with reduction of irritation to the elbow has rarely been reported. This study introduces a minimally invasive elbow MCL reconstruction technique and evaluates the valgus stability.Methods: Eight fresh-frozen elbow specimens underwent reconstruction of the anterior bundle of the MCL (AMCL) first with the flexor carpi ulnaris fascia patches, followed by reconstruction of the posterior bundle of the MCL (PMCL) with the triceps tendon patches. The valgus angles of each specimen were examined in three stages as follows: intact MCL, reconstruction of the AMCL alone, and reconstruction of the MCL (including AMCL and PMCL). Finally, specimens were loaded to failure, and failure modes were recorded.Results: AMCL reconstruction alone had similar valgus stability at all testing angles (p = 0.080, 30° flexion; p = 0.064, 60° flexion; p = 0.151, 90° flexion; p = 0.283, 120° flexion) compared with the intact MCL, as did MCL reconstruction (p = 0.951, 30° flexion; p = 0.739, 60° flexion; p = 0.841, 90° flexion; p = 0.538, 120° flexion). More importantly, a significant difference existed between the MCL reconstruction and the AMCL reconstruction alone at 30° flexion (p = 0.043) and 60° flexion (p = 0.013) but not at the 90° flexion (p = 0.369) and 120° flexion (p = 0.879). The mean maximum failure torque of MCL reconstruction was 24.02 Nm at 90° elbow flexion.Conclusion: Both AMCL reconstruction alone and MCL reconstruction provided valgus stability comparable with the native MCL, and importantly, MCL reconstruction provided more valgus stability than AMCL reconstruction alone at 30° flexion and 60° flexion of the elbow. Therefore, the new MCL reconstruction technique might be a useful guide for the treatment of elbow MCL injuries or deficiencies.
Development of Tumor Mutation Burden-Related Prognostic Model and Novel Biomarker Identification in Stomach Adenocarcinoma
Authors: Fu Min , Huang Yongbiao , Peng Xiaohong , Li Xiaoyu , Luo Na , Zhu Wenjun , Yang Feng , Chen Ziqi , Ma Shengling , Zhang Yuanyuan , Li Qianxia , Hu Guangyuan 
Published: March 2022

Background: Stomach adenocarcinoma (STAD) is one of the most common tumors. Tumor mutation burden (TMB) has been linked to immunotherapy response. We wanted to see if there was any link between TMB and cancer prognosis.Methods: The Cancer Genome Atlas (TCGA) and the Gene Expression Omnibus (GEO) databases were used to obtain mutation data, gene expression profiles, and clinical data. We looked at the differences in gene expression and immune markers between low and high TMB groups, built an immune prognostic model, and created a dynamic nomograph App that may be used in the clinic. Simultaneously, We ran the immunotherapy prediction and model comparison at the same time. Finally, model gene mutation and copy number variation (CNV) were displayed. The cellular functional experiments were used to investigate the potential role of GLP2R in gastric cancer.Results: Firstly, basic mutation information and differences in immune infiltration in STAD are revealed. Secondly, the prognostic model developed by us has good accuracy, and the corresponding dynamic nomograph Apps online and immunotherapy prediction facilitate clinical transformation. Furthermore, GLP2R knockdown significantly inhibited the proliferation, migration of gastric cancer cells in vitro.Conclusion: Our findings imply that TMB plays a significant role in the prognosis of STAD patients from a biological perspective. GLP2R may serve as a potential target for gastric cancer.
A Predicted Model for Refractory/Recurrent Cytomegalovirus Infection in Acute Leukemia Patients After Haploidentical Hematopoietic Stem Cell Transplantation
Authors: Shen Meng-Zhu , Hong Shen-Da , Wang Jie , Zhang Xiao-Hui , Xu Lan-Ping , Wang Yu , Yan Chen-Hua , Chen Huan , Chen Yu-Hong , Han Wei , Wang Feng-Rong , Wang Jing-Zhi , Liu Kai-Yan , Huang Xiao-Jun , Mo Xiao-Dong 
Published: March 2022

ObjectiveWe aimed to establish a model that can predict refractory/recurrent cytomegalovirus (CMV) infection after haploidentical donor (HID) hematopoietic stem cell transplantation (HSCT).MethodsConsecutive acute leukemia patients receiving HID HSCT were enrolled (n = 289). We randomly selected 60% of the entire population (n = 170) as the training cohort, and the remaining 40% comprised the validation cohort (n = 119). Patients were treated according to the protocol registered at https://clinicaltrials.gov (NCT03756675).ResultsThe model was as follows: Y = 0.0322 × (age) – 0.0696 × (gender) + 0.5492 × (underlying disease) + 0.0963 × (the cumulative dose of prednisone during pre-engraftment phase) – 0.0771 × (CD34+ cell counts in graft) – 1.2926. The threshold of probability was 0.5243, which helped to separate patients into high- and low-risk groups. In the low- and high-risk groups, the 100-day cumulative incidence of refractory/recurrent CMV was 42.0% [95% confidence interval (CI), 34.7%–49.4%] vs. 63.7% (95% CI, 54.8%–72.6%) (P &lt; 0.001) for total patients and was 50.5% (95% confidence interval (CI), 40.9%–60.1%) vs. 71.0% (95% CI, 59.5%–82.4%) (P = 0.024) for those with acute graft-versus-host disease. It could also predict posttransplant mortality and survival.ConclusionWe established a comprehensive model that could predict the refractory/recurrent CMV infection after HID HSCT.Clinical Trial Registrationhttps://clinicaltrials.gov, identifier NCT03756675.
Will Smartphone Applications Replace the Insertable Cardiac Monitor in the Detection of Atrial Fibrillation? The First Comparison in a Case Report of a Cryptogenic Stroke Patient
Authors: Wouters Femke , Gruwez Henri , Vranken Julie , Ernon Ludovic , Mesotten Dieter , Vandervoort Pieter , Verhaert David 
Published: March 2022

Background and CaseThis case report exemplifies the clinical application of non-invasive photoplethysmography (PPG)-based rhythm monitoring in the awakening mobile health (mHealth) era to detect symptomatic and asymptomatic paroxysmal atrial fibrillation (AF) in a cryptogenic stroke patient. Despite extensive diagnostic workup, the etiology remains unknown in one out of three ischemic strokes (i.e., cryptogenic stroke). Prolonged cardiac monitoring can reveal asymptomatic atrial fibrillation in up to one-third of this population. This case report describes a cryptogenic stroke patient who received prolonged cardiac monitoring with an insertable cardiac monitor (ICM) as standard of care. In the context of a clinical study, the patient simultaneously monitored his heart rhythm with a PPG-based smartphone application. AF was detected simultaneously on both the ICM and smartphone application after three days of monitoring. Similar AF burden was detected during follow-up (five episodes, median duration of 28 and 34 h on ICM and mHealth, respectively, p = 0.5). The detection prompted the initiation of oral anticoagulation and AF catheter ablation procedure.ConclusionThis is the first report of the cryptogenic stroke patient in whom PPG-based mHealth was able to detect occurrence and burden of the symptomatic and asymptomatic paroxysmal AF episodes with similar precision as ICM. It accentuates the potential role of PPG-based mHealth in prolonged cardiac rhythm monitoring in cryptogenic stroke patients.
Three-Dimensional Distribution of Platinum Group Minerals in Natural MSS-ISS Ores From the Norilsk One Deposit, Russia
Authors: Sittner J. , Brovchenko V. , Siddique A. , Buyse F. , Boone M. , Renno A.D. , Cnudde V. , Merkulova M. , Sluzhenikin S.F. 
Published: March 2022

The Mt. Rudnaya MSS-ISS (monosulfide and intermediate solid solution) fine-grained ores from a NE termination of Norilsk 1 deposit were analyzed using a combination of X-ray computed micro tomography, spectral X-ray computed micro tomography and scanning electron microscopy to achieve both, 2D and 3D data. The ores consist of ISS composed of tiny lamellar intergrowths of cubanite and chalcopyrite solid solutions, which form up to 4-mm distinct globules surrounded by an ISS-MSS matrix. Our X-ray computed micro tomography results may provide 3D textural evidence of a possible natural sulfide-sulfide liquid immiscibility between Cu-rich and Cu-poor sulfide liquids that occurred before MSS and ISS were crystallized. The platinum group minerals (PGM) distribution shows that 20.6 vol% of all PGM occur in the ISS-MSS matrix and 79.4 vol% in the ISS globules. We suggest that this distributional behavior is due to the fact that the platinum group elements (PGE) cannot be dissolved in ISS, which led to the formation of the large PGM grains, which are up to 120 μm on their longest axis. The initial enrichment of ISS in PGE was controlled by differences in the partition coefficients of platinum and palladium between Cu-poor and Cu-rich liquids.
Multi-Decadal Glacier Area and Mass Balance Change in the Southern Peruvian Andes
Authors: Taylor Liam S. , Quincey Duncan J. , Smith Mark W. , Potter Emily R. , Castro Joshua , Fyffe Catriona L. 
Published: March 2022

Around 70% of the world’s tropical glaciers are located in Peru, and they are melting rapidly in response to climate change. The glaciers of the data-sparse Southern Peruvian Andes, comprising the Cordilleras Vilcanota, Vilcabamba, and Urubamba, are a primary water source for thousands of people living in the rural foothills, and support people throughout the wider Cusco region. Here, we calculate geodetic mass balance for the Cordillera Vilcanota (−0.48 ± 0.07 m w.e. yr−1) using the ASTER satellite archive and derive a total loss of 3.18 ± 0.44 Gt ice between 2000 and 2020. Glacierised area has shrunk rapidly since the 1970s (losses of 54, 56, and 64% for the Cordilleras Vilcanota, Vilcabamba, and Urubamba respectively) as a consequence of changing climatic patterns, with low-lying glaciers receding the most across all regions. We calculate a rise in the median elevation of glaciers ranging from 15.9 m per decade over the Quelccaya ice cap in the Cordillera Vilcanota, to 32.8 m per decade in the Cordillera Vilcabamba, over the period 1975 to 2020. This change implies an increased hazard potential as the mountain regions become destabilised, and will lead to increasing pressure on fresh water supply as meltwater streamflow decreases and river discharge becomes increasingly, and irreversibly, variable.
Research on the Bonding Performance of UHPC–NC Interfaces With Different Sizes of Grooves
Authors: Yang Jun , Xia Junrun , Cheng Chongsheng , Wang Jieyun , Zhang Jie , Wang Gang 
Published: March 2022

The interfacial treatment between normal concrete (NC) and ultra-high–performance concrete (UHPC) is crucial to ensure bonding strength. Grooving is an effective method to treat the UHPC–NC interface, but the shear properties and failure modes at the composite interface remain under-investigated. This study focuses on the bonding performance of different groove designs (width, spacing, and angle) at the UHPC–NC interface, and push-off tests with 15 specimens were carried out to evaluate the strength and stiffness. Furthermore, a finite element model (FEM) and calculation methods were validated with the experimental study to reveal the bonding strength, and a parametric study on the groove depth was also carried out. The interface treated by grooves increases 3.32 and 2.48 times in strength and stiffness compared with specimens bonded by epoxy resin adhesive. The results also show that failing at the interface and NC matrix made up a majority of the failure modes. The shear strength of the UHPC–NC interface increased with the width and decreased with the space between the grooves. Grooves with 10 mm width, 100 mm space, 25 mm depth, and right angle were recommended. This paper will lay a foundation for the surface preparation of UHPC strengthening NC bridges.
Novel Method for the Growth of Two-Dimensional Layered InSe Thin Films on Amorphous Substrate by Molecular Beam Epitaxy
Authors: Hsiao Sheng-Wei , Yang Chu-Shou , Yang Hao-Ning , Wu Chia-Hsing , Wu Ssu-Kuan , Chang Li-Yun , Ho Yen-Teng , Chang Shu-Jui , Chou Wu-Ching 
Published: March 2022

A two-dimensional (2D) material known as indium selenide (InSe) is widely considered a promising layered semiconductor with potential applications in electronics and optoelectronics. However, the single phase of InSe is still a challenge due to the close formation energy of InSe and In2Se3. In this study, we demonstrate a novel growth method for 2D InSe with an indium precursor layer by molecular beam epitaxy. Indium pre-deposited on substrate at room temperature followed by growth of InSe at 550°C can overcome the problem of stoichiometry control and can be applied on amorphous substrate with high quality. According to Raman scattering spectra, X-ray diffraction, and high-resolution transmission electron microscopy results, we find that 2D InSe phase can be facile formed under both indium-rich and -poor conditions. The pre-deposited indium precursor effectively induces replacement with subsequent Se and In atoms to form the InSe phase while suppressing the In2Se3 phase. Additionally, this single phase InSe is stable in the atmosphere, exhibiting superior electronic properties even after over 100 days exposure. Recently, this method has been successfully applied to a flexible substrate, such as aluminum foil, resulting in reliable InSe quality. Our results demonstrate an innovative and forward-looking approach to developing 2D InSe material.
CT-Visible Convexity Subarachnoid Hemorrhage Predicts Early Recurrence of Lobar Hemorrhage
Authors: Yang Qiong , Zeng Xiangzhu , Yu Zhou , Liu Xiaolu , Tang Lu , Zhang Gaoqi , Tian Danyang , Li Nan , Fan Dongsheng 
Published: March 2022

Background and PurposeConvexity subarachnoid hemorrhage (cSAH) may predict an increased recurrence risk in cerebral amyloid angiopathy (CAA)-related intracerebral hemorrhage (ICH) survivors. We aimed to investigate whether cSAH detected on CT was related to early recurrence in patients with ICH related to CAA.MethodsWe analyzed data from consecutive lobar ICH patients diagnosed as probable or possible CAA according to the Boston criteria using the method of cohort study. Demographic and clinical data, ICH recurrence at discharge and within 90 days were collected. The association between cSAH detected on CT and early recurrent ICH was analyzed using multivariable logistic regression.ResultsA total of 197 cases (74 [66–80] years) were included. cSAH was observed on the baseline CT of 91 patients (46.2%). A total of 5.1% (10/197) and 9.5% (17/179) of patients experienced ICH recurrence within 2 weeks and 90 days, respectively. The presence of cSAH was related to recurrence within 2 weeks (OR = 5.705, 95%CI 1.070–30.412, P = 0.041) after adjusting for hypertension, previous symptomatic ICH and anticoagulant use. The presence of cSAH was related to recurrence within 90 days (OR 5.473, 95%CI 1.425–21.028, P = 0.013) after adjusting for hypertension, previous symptomatic ICH and intraventricular hemorrhage. The similar results were obtained in other models using different methods to select adjusting variables.ConclusionIn patients with lobar ICH related to CAA, 5.1% and 9.5% of them experienced ICH recurrence within 2 weeks and 90 days, respectively. CT-visible cSAH was detected in 46.2% of patients and indicates an increased risk for early recurrent ICH.
Probenecid-Blocked Pannexin-1 Channel Protects Against Early Brain Injury via Inhibiting Neuronal AIM2 Inflammasome Activation After Subarachnoid Hemorrhage
Authors: Zheng Yonghe , Tang Wenwen , Zeng Hanhai , Peng Yucong , Yu Xiaobo , Yan Feng , Cao Shenglong 
Published: March 2022

AimPrevious studies have proved that inhibiting inflammasome activation provides neuroprotection against early brain injury (EBI) after subarachnoid hemorrhage (SAH), which is mainly focused on the microglial inflammatory response, but the potential role of neuronal inflammasome activation in EBI has not been clearly identified. This study examined whether the pannexin-1 channel inhibitor probenecid could reduce EBI after SAH by inhibiting neuronal AIM2 inflammasome activation.MethodsThere are in vivo and in vitro parts in this study. First, adult male SD rats were subjected to the endovascular perforation mode of SAH. The time course of pannexin-1 and AIM2 expressions were determined after SAH in 72 h. Brain water content, neurological function, AIM2 inflammasome activation, and inflammatory response were evaluated at 24 h after SAH in sham, SAH, and SAH + probenecid groups. In the in vitro part, HT22 cell treated with hemin was applied to mimic SAH. The expression of AIM2 inflammasome was detected by immunofluorescence staining. Neuronal death and mitochondrial dysfunction were determined by the LDH assay kit and JC-1 staining.ResultsThe pannexin-1 and AIM2 protein levels were upregulated after SAH. Pannexin-1 channel inhibitor probenecid attenuated brain edema and improved neurological dysfunction by reducing AIM2 inflammasome activation and reactive oxygen species (ROS) generation after SAH in rats. Treating HT22 cells with hemin for 12 h resulted in AIM2 and caspase-1 upregulation and increased mitochondrial dysfunction and neuronal cell death. Probenecid significantly attenuated the hemin-induced AIM2 inflammasome activation and neuronal death.ConclusionsAIM2 inflammasome is activated in neurons after SAH. Pharmacological inhibition of the pannexin-1 channel by probenecid attenuated SAH-induced AIM2 inflammasome activation and EBI in vivo and hemin-induced AIM2 inflammasome activation and neuronal death in vitro.
Effect of Probiotics Supplementation on Heart Rate: A Systematic Review and Meta-Analysis of Randomized Clinical Trials
Authors: Han Shufen , Li Yuezhen , Song Ruijuan , Gao Hui , Zhang Weiguo 
Published: March 2022

Background and AimsProbiotics consumption lowers the risk of cardiovascular disease, but whether it affects heart rate (HR) remains controversial. Therefore, our study aimed to assess the chronotropic effects of probiotics on heartbeat via a meta-analysis of randomized clinical trials.MethodsRelevant studies were identified by searching PubMed, Cochrane library, and Clinical Trials databases up to October 2021. Either a fixed-effects or a random-effects model was used to calculate the pooled effect sizes and 95% confidence intervals (CIs).ResultsThis meta-analysis included 13 studies involving 16 interventional trial arms and 931 participants according to inclusion criteria. The overall pooled estimate showed that probiotics supplementation had a slight, but no significant reduction of 0.28 bpm (95% CI: −1.17, 0.60) on HR. Relatively high heterogeneity was observed among included trials (I2 = 80.8%, P heterogeneity &lt; 0.001). Subgroup analysis displayed that probiotics supplementation significantly reduced HR by 2.94 bpm (95% CI: −5.06, −0.82) among participants with baseline HR ≥ 75 bpm, by 1.17 bpm (95% CI: −2.34, −0.00) with probiotics dose ≥1 × 1010 CFU/day, and by 1.43 bpm (95% CI: −2.69, −0.17) with multiple-strain intervention. Meta-regression analysis showed that baseline HR was a major potential effect modifier of probiotics supplementation on lowering HR.ConclusionHitherto, the overall evidence in the literature was insufficient to support the notion that probiotics supplementation has a class effect on HR reduction. However, in subgroup analysis, probiotics reduced HR significantly in those who had higher baseline HR, received a higher dose or multiple strains of probiotics.
Analysis of the Clinical Characteristics of Spontaneous Bile Duct Perforation in Children
Authors: Yan Xueqiang , Zheng Nannan , Jia Jinfu , Kuang Houfang , Lei Haiyan , Bian Hongqiang , Qin Xinke , Sun Xuan , Duan Xufei , Zhan Jianghua 
Published: March 2022

ObjectiveThis study aimed to explore the etiology, clinical features, diagnosis, and treatment of spontaneous bile duct perforation (SBDP) in children.MethodsThe clinical data of children with SBDP who were admitted to Wuhan Children's Hospital between January 2014 and January 2020 were retrospectively analyzed.ResultsIn all, 28 cases of children with SBDP (male, 28.6%; female, 71.4%; male-to-female ratio, 1:2.5; average age, 2.15 years) were analyzed. The most common symptoms were fever (85.7%), nausea and vomiting (78.6%), and abdominal distension (67.9%). Among the 28 patients, 26 (92.9%) had elevated hypersensitive C-reactive protein, 24 (85.7%) had an increased neutrophil percentage, and 22 (78.6%) had raised peripheral blood leukocyte counts. Moreover, 19 patients (67.9%) showed increased serum total bilirubin levels, and 5 (17.9%) showed an elevated conjugated bilirubin level. Abdominal CT examination revealed that the gallbladder wall of patients was thickened with edema, accompanied by gallbladder stenosis and gallbladder mucosa enhancement; furthermore, ascites was found in the abdominal cavity and lesser omental bursa. Twenty-two patients underwent abdominal paracentesis, and 20 (90.9%) of them were exposed to bile-based ascites. Among the 28 patients, four recovered with conservative treatment, whereas the others (85.7%) were surgically treated. Of the twenty-four patients undergoing surgery, the perforation site was found at the union of the hepatic and cystic ducts in 12 patients (50%), no perforation site was observed in 9 patients (37.5%), and a common hepatic duct was observed in 3 patients (12.5%). All 24 patients underwent stage I surgery, and temporary biliary drainage was performed because of severe abdominal inflammation. Cholangiography and enhanced CT revealed an abnormal location of the pancreatic duct joining the bile duct in 64.3% patients. Following surgery, 15 patients underwent hepaticojejunostomy. Subsequently, 3-month to 6-year follow-up (median, 30 months) indicated that the patients recovered well with no serious complications.ConclusionSBDP in children may be associated with pancreaticobiliary malunion (PBM) and congenital weakness of the bile duct wall. However, the clinical manifestations of this condition lack specificity; this limitation can be assisted through diagnosis via abdominal CT and by performing abdominal paracentesis. Once SBDP diagnosis is confirmed, the patient should follow the principles of individualized treatment.
A Wideband Controllable Bandpass Filter Based on Spoof Surface Plasmon Polaritons
Authors: Chen Xi , Cheng Chonghu , Liu Leilei 
Published: March 2022

A wideband controllable band-pass filter is proposed, which is based on the spoof surface plasmon polaritons (SSPP) and slip ring resonators (SRR). The design concept of the bandpass filter is using the SSPP and SRR to control the high cut-off frequency and filter the low-frequency wave, respectively. The bandpass filter is used diode reconfigurable technology to tunable the bandwidth. The filter has a passband range of 5–9 GHz, an out-band rejection of −20 dB for the lower sideband, and an out-band rejection of −50 dB for the upper sideband. The simulated and measured results are in good agreement over the operating band. Benefit from its low-profile and low-cost, the proposed bandpass filter has a great potential for development in plasmonic functional devices at microwave frequencies.