bluuebunny/crossref_metadata_2025_split huggingface dataset:
Belzutifan: A Narrative Drug Review
Authors: Visweswaran Vysakh , Pavithran Keechilat 
Published: April 2022

Abstract:
Von Hippel-Lindau disease is an autosomal dominant disorder characterised by renal
cell carcinomas, pancreatic neuroendocrine tumours, central nervous system hemangioblastomas,
retinoblastomas, and tumours of the reproductive tract. This disease results from loss of function
mutations in the tumour suppressor gene known as the Von Hippel-Lindau gene, located on
chromosome 3. Loss of function mutation in the Von Hippel-Lindau gene results in the
accumulation of a protein known as a hypoxia-inducible factor, which promotes cellular
proliferation and angiogenesis, leading to cancer. Belzutifan inhibits the hypoxia-inducible factor
by binding to the Per-ARNT -Sim-B binding pocket on the hypoxia-inducible factor -2α, inhibiting
cellular proliferation and angiogenesis. In our thorough literature review, we identified 37 relevant
articles. Belzutifan showed clinically meaningful response rates for both Von Hippel-Lindau
disease-associated renal cell carcinomas and non-renal cell cancers. The pharmacokinetic profile
of belzutifan was much better than its congener molecules due to the optimisation of its dihalide
groups from germinal to vicinal. The pharmacodynamic effect of belzutifan was confirmed by its
ability to decrease serum erythropoietin, which is a direct result of hypoxia-inducible factor- 2α
inhibition. The significant side effects observed were anaemia, hypoxia, fatigue, hypertension,
visual impairment and weight gain. Multiple clinical trials are currently underway to determine the
role of beluztifan as part of combination regimens in treating Von Hippel-Lindau diseaseassociated
malignancies.
Children With Medical Complexity in the Canadian Maritimes: Protocol for a Mixed Methods Study
Authors: Breneol Sydney , Curran Janet A , Macdonald Marilyn , Montelpare William , Stewart Samuel A , Martin-Misener Ruth , Vine Jocelyn 
Published: April 2022

Background
Ongoing developments in the medical field have improved survival rates and long-term management of children with complex chronic health conditions. While the number of children with medical complexity is small, they use a significant amount of health resources across various health settings and sectors. Research to date exploring this pediatric population has relied primarily on quantitative or qualitative data alone, leaving significant gaps in our understanding of this population.

Objective
The objective of this research is to use health administrative and family-reported data to gain an in-depth understanding of patterns of health resource use and health care needs of children with medical complexity and their families in the Canadian Maritimes.

Methods
An explanatory sequential mixed methods design will be used to achieve our research objective. Phase 1 of this research will leverage the use of health administrative data to examine the prevalence and health service use of children with medical complexity. Phase 2 will use case study methods to collect multiple sources of family-reported data to generate a greater understanding of their experiences, health resource use, and health care needs. Two cases will be developed in each of the 3 provinces. Cases will be developed through semistructured interviews with families and their health care providers and health resource journaling. Findings will be triangulated from phase 1 and 2 using a joint display table to visually depict the convergence and divergence between the quantitative and qualitative findings. This triangulation will result in a comprehensive and in-depth understanding into the population of children with medical complexity.

Results
This study will be completed in May 2022. Findings from each phase of the research and integration of the two will be reported in full in 2022.

Conclusions
There is a current disconnect between the Canadian health care system and the needs of children with medical complexity and their families. By combining health administrative and family-reported data, this study will unveil critical information about children with medical complexity and their families to more efficiently and effectively meet their health care needs. Results from this research will be the first step in designing patient-oriented health policies and programs to improve the health care experiences, health system use, and health outcomes of children with medical complexity and their families.

International Registered Report Identifier (IRRID)
DERR1-10.2196/33426
COMPARISON OF PUBLIC'S INTEREST IN SELECTING TRADITIONAL AND MODERN MEDICINE THERAPY
Authors: FITRIAH RAHMAYANTI , HIDAYATI RAHMI , MUTHIA REZKY HENY 
Published: April 2022

Objective: This study aims to determine the public's interest in selecting traditional medicine or modern medicine and the factors that influence this interest in Loktabat Selatan Village, Banjarbaru City, South Kalimantan Province, Indonesia.
Methods: The research method used a Cross-Sectional approach. The data were collected from 100 respondents of Loktabat Selatan Village people, Banjarbaru City, using an instrument in questionnaire form.
Results: The comparison result of the interest of the therapy choice showed in traditional medicine interest was 58%, and modern medicine was 42%. For the comparison of respondents' interests results based on internal factors were 55.2% which was a decent category, and external factors were 53.4% which was enough category. Data analysis using the Chi-Square test obtained a sig value of 0.814>0.05, then H0 is accepted.
Conclusion: There is a comparison of public interest in selecting of traditional and modern medicine therapy in South Loktabat Village, Banjabaru City, South Kalimantan Indonesia.
EFFECT OF VANILLIN QUALITY ON THE SYNTHESIS AND SOLID DISPERSION SYSTEMS ON PGV-0 ANTIOXIDANT CAPACITY
Authors: RAMADHAN HAFIZ , FORESTRYANA DYERA , ADISAPUTRA GUSTI TIRTA , MUHARRAM SITI RAHMAH 
Published: April 2022

Objective: Pentagamavunon-0 (PGV-0) was a curcumin analog with antioxidant properties and has been synthesizing with improvement techniques using vanillins with different qualities. PGV-0 has a low bioavailability but could be increased solubility by making a solid dispersion system. This study aimed to determine the antioxidant properties of PGV-0 that were synthesized with different quality starting materials of vanillin and also to obtain the effect of PEG 6000 and maltodextrin solid dispersion systems.
Methods: PGV-0 was synthesizing by mixing cyclopentanone into two different groups of vanillins (vanillin pro analysis and vanillin “Kapal Layar”) using an HCl catalyst. The purity of products was identified with TLC (Thin Layer Chromatography) and spectrophotometrically compared with PGV-0 standard. Solid dispersion system consisting of two treatment groups: PEG 6000 and maltodextrin groups. The measurement of antioxidant properties was examined by Cupric Ion Reducing Antioxidant Capacity (CUPRAC).
Results: PGV-0 of vanillin pro analysis group (EC50= 13.62 ppm) was found higher antioxidant capacity as compared to the vanillin “Kapal Layar” group (EC50= 15.35 ppm). The solid dispersion system of PGV-0-PEG 6000 at ratio 1:10 has shown powerful antioxidant capacity (EC50= 9.00 ppm) than the PGV-0-PEG 6000 at ratio 1:5 group (EC50= 10.65 ppm). PGV-0-maltodextrin at ratio 1:10 (EC50= 11.96 ppm) also has powerful antioxidant activity when compared with PGV-0-maltodextrin at ratio 1:5 (EC50= 13.63 ppm).
Conclusion: The results of the study showed that the use of vanillin with different qualities in PGV-0 synthesis and also solid dispersion systems can affect the antioxidant activity of PGV-0.
INTENSIVE MONITROING OF SINOVAC VACCINE FOR SAFETY AND EFFICACY AMONG INDONESIAN POPULATION
Authors: KEZIA VALERIE , RAMATILLAH DIANA LAILA 
Published: April 2022

Objective: To Evaluate intensively patients taking Sinovac-CoronaVac vaccine for the side effects and effectiveness in preventing COVID infection.
Methods: This is a prospective crossectional study using convenience sampling for all Indonesian populations who received full dose of Sinovac-CoronaVac vaccine.
Results: The efficacy and safety of the Sinovac-CoronaVac vaccine is 96.8%. factors that influence efficacy and safety are side effects with Age, BMI and Gender with p-value<0.05.
Conclusion: There is correlation between side effects of Sinovac-CoronaVac with Age, BMI and Gender for safety and efficacy.
Kajian unit pelaksana teknis daerah (UPTD) jalan dan jembatan wilayah V sebagai pelaksana pemeliharaan rutin jalan provinsi dengan cara swakelola
Authors: Putra Afrisol , Despa Dikpride , Wardono Herry 
Published: April 2022

Undang-undang No. 23 Tahun 2014 tentang Pemerintahan Daerah dan Undang-undang No. 38 Tahun 2004 tentang Jalan memberikan keleluasaan kepada pemerintah daerah untuk mengatur urusan penyelenggaraan jalan yang menjadi wewenangnya. Salah satu bentuk penyelenggaraan jalan provinsi adalah melaksanakan kegiatan pemeliharaan rutin jalan secara swakelola melalui Unit Pelaksana Teknis Daerah (UPTD) Dinas Bina Marga dan Bina Konstruksi Provinsi Lampung. Berdasarkan Peraturan Gubernur Lampung Nomor 10 Tahun 2020 Tanggal 25 Februari 2020 tentang Pembentukan, Organisasi dan Tata Kerja Cabang Daerah dan Unit Pelaksana Teknis Daerah pada Perangkat Daerah Provinsi Lampung, menyatakan bahwa UPTD Jalan dan Jembatan Wilayah V mempunyai tugas melaksanakan pemantauan dan pengendalian, pemeliharaan serta bangunan pelengkapnya di wilayah kerjanya, untuk menyelenggarakan tugas UPTD Jalan dan Jembatan Wilayah V mempunyai fungsi pelaksanaan, pemantauan dan pengendalian tingkat pelayanan jalan dan jembatan, pelaksanaan pemeliharaan tingkat pelayanan jalan dan jembatan, pengkoordinasian operasional pengguna dan pemanfaatan peralatan milik bidang bina marga dan bina konstruksi di wilayah kerjanya; dan pelaksanaan pengelolaan urusan ketatausahaan. Wilayah kerja UPTD Jalan dan Jembatan Wilayah V, meliputi koridor yang berada di Kabupaten Lampung Barat, Kabupaten Pesisir Barat dan Kabupaten Tanggamus, yang berkedudukan di Liwa Kabupaten Lampung Barat. Dari hasil kajian dapat diketahui bahwa pada aspek sumber daya manusia, UPTD Jalan dan Jembatan Wilayah V telah mampu melakukan pemeliharaan rutin jalan secara swakelola, selanjutnya pemeliharaan dilakukan secara berkelanjutan terhadap semua ruas jalan yang telah dibangun di wilayah kerjanya. Pada aspek pelaksanaan pekerjaan swakelola pemeliharaan jalan melibatkan peran serta pekerja jalan, mandor yang berlokasi diruas jalan tersebut, pemeliharaan rutin jalan dilaksanakan selama 12 bulan dan berpedoman pada Peraturan LKPP Nomor RI Nomor 8 Tahun 2018 tentang Pedoman swakelola dan terakhir keluar Peraturan LKPP RI Nomor 3 Tahun 2021 tentang pedoman swakelola sebagai panduan dalam pemeliharaan rutin jalan. Beberapa langkah yang dapat dilakukan untuk meningkatkan ilmu pengetahuan, keterampilan dan penguasaan teknologi untuk SDM UPTD wilayah V melalui pelatihan langsung praktek, melakukan penataan pegawai kontrak non PNS yang berlokasi tinggal diruas jalan dapat menjadi juru jalan, dan perlunya aturan penentuan tentang prioritas pemeliharaan jalan sehingga kondisi jalan tetap mantap.
Permasalahan Kelembagaan Pemanfaatan Bendungan Way Rarem untuk Kegiatan Budidaya Keramba Jaring Apung di Kabupaten Lampung Utara
Authors: David Ashari  , Tumijo  
Published: April 2022

Bendungan Way Rarem merupakan salah satu sumber daya air yang potensial untuk memenuhi kebutuhan air bersih masyarakat Kabupaten Lampung Utara. Masifnya aktivitas kegiatan perikanan Keramba Jaring Apung (KJA) berdampak pada penurunan kualitas lingkungan di sekitar Bendungan Way Rarem.. Penelitian bertujuan untuk menganalisis permasalahan kelembagaan pemanfaatan Bendungan Way Rarem untuk kegiatan perikanan KJA di Kabupaten Lampung Utara. Pendekatan kualitatif digunakan dalam penelitian ini yang didukung oleh data hasil wawancara kepada pemerintah pusat dan daerah dan petani KJA. Hasil penelitian menunjukkan bahwa kelembagaan pemanfaatan Bendungan Way Rarem tidak berjalan baik dilihat dari aspek kebijakan, peran dan kewenangan, dan koordinasi stakeholder. Dari aspek kebijakan, terdapat tumpang tindih peraturan antara pemerintah pusat dan pemerintah daerah, tidak ada prosedur perizinan yang diberlakukan untuk kegiatan KJA, dan kurangnya sosialisasi mengenai kebijakan dan aturan pemanfaatan keramba kepada masyarakat maupun lembaga terkait. Dari aspek peran dan kewenangan, ada perubahan wewenang dari pemerintah daerah kepada pemerintah pusat, sumber daya manusia untuk mengelola Bendungan Way Rarem kualitasnya masih rendah, dan aktivitas perikanan KJA yang tidak terkoordinir dengan baik. Dari aspek koordinasi, belum ada koordinasi langsung antar instansi yang terlibat dalam pemanfaatan waduk, Tim Koordinasi Pengelolaan Sumber Daya Air (TKPSDA) sebagai wadah koordinasi belum berjalan dengan baik, dan adanya missing link antara pemerintah pusat (BBWS) dan pemerintah daerah. Temuan ini mengindikasikan bahwa pemerintah sebagai otoritas perlu membuat suatu konsep kelembagaan dengan model hubungan integrated administrative system agar tercipta hubungan yang harmonis antara pemerintah pusat dan pemerintah daerah
Hysteresis and stochastic convergence in Eurozone unemployment rates: evidence from panel unit roots with smooth breaks and asymmetric dynamics
Authors: Corakci Aysegul , Omay Tolga , Hasanov Mubariz 
Published: April 2022

Research background: Studying the dynamic characteristics of unemployment rate is crucial for both economic theory and macroeconomic policies. Despite numerous research, the empirical evidence about stochastic behaviour of the unemployment rate remains disputable. It has been widely agreed that most economic variables, including unemployment rates, are characterized by both structural breaks and nonlinearities. However, a little work is done to examine both features simultaneously.
Purpose of the article: In this paper, we analyse the stationarity properties of unemployment rates of Euro area member countries. Also, we aim to test stochastic convergence of unemployment rates among member countries. Our empirical procedures explicitly allow for simultaneous gradual breaks and nonlinearities in the series.
Methods: This paper develops a new unit root test procedure for panel data, allowing for both gradual structural breaks and asymmetric adjustment towards equilibrium. We carry out Monte Carlo simulations to examine small sample performance of the proposed test procedure and compare it to the existing test procedures. We apply the newly proposed test to examine the stochastic properties of the unemployment rates of Euro-member countries as well as relative unemployment rates vis-?-vis the Eurozone unemployment rate.
Findings & value added: We find that the newly developed test procedure outperforms existing tests in highly nonlinear settings. Also, these tests reject the null hypothesis of unit root in more cases when compared to the existing tests. We find stationarity in the series only after allowing for structural breaks in the data generating process. Allowing for nonlinear and asymmetric adjustment in addition to gradual breaks provides evidence of stationarity in more cases. Furthermore, our results suggest that relative unemployment rate series are stationary, providing evidence in favour of stochastic convergence in unemployment rates. Overall, our results imply a limited room for coordinated economic policy to fight unemployment in the Eurozone.
Veterinary antimicrobial prescribing practices for treatment of presumptive sporadic urinary tract infections in dogs examined at primary care practices in the United States (2010–2019)
Authors: Bloch Rebecca A. , Papich Mark G. , Stürmer Til 
Published: April 2022

Abstract

OBJECTIVE
To describe patterns of antimicrobial prescriptions for sporadic urinary tract infections (UTIs) in dogs in the United States from 2010 through 2019, including times before and after publication of International Society for Companion Animal Infectious Disease (ISCAID) guidelines.

SAMPLE
461,244 qualifying visits for sporadic UTIs.

PROCEDURES
Veterinary electronic medical records of a private corporation consisting of > 1,000 clinics across the United States were examined to identify canine visits for potential sporadic UTI between January 1, 2010, and December 31, 2019. Proportions of antimicrobial prescriptions were graphed by month and year to identify changes in prescription patterns over time. Interrupted time series analysis was performed for the aminopenicillins.

RESULTS
A total of 461,244 qualifying visits were examined, with 389,949 (85%) of these resulting in at least 1 antimicrobial prescription. Over the 10-year period, the proportion of visits resulting in no antimicrobial prescription increased (14% in 2010 to 19.7% in 2019). Proportions of prescriptions for amoxicillin (38% to 48%) and amoxicillin–clavulanic acid (2.5% to 10%) also increased. Log-linear regression supported that changes in proportions of amoxicillin and amoxicillin–clavulanic acid prescriptions occurred following the 2011 ISCAID guidelines publication, with the proportion of amoxicillin prescriptions increasing by 13% per year (95% CI, 12% to 14%; P < 0.01) and the proportion of amoxicillin–clavulanic acid prescriptions increasing by 0.5% per year (95% CI, 0.2% to 0.8%; P < 0.01). Use of fluoroquinolones and third-generation cephalosporins remained constant.

CLINICAL RELEVANCE
Results suggest that efforts to guide antimicrobial use in veterinary clinical practice are having positive effects in this private veterinary company, though continued efforts are warranted.
Expression and biochemical significance of Piwil2 in stem cell lines
Authors: Kaan Dilek 
Published: April 2022

Abstract

Introduction
P-element induced wimpy testis-like 2 (Piwil2) is in the Piwi gene family. Piwil2 has important roles in the self-renewal mechanism of stem cell induction and progression of numerous types of human malignancies such as lung, breast, colon, prostate, and cervical cancers. Glutathione S-transferase (GST) acts as detoxification in cancer metabolism. This study aimed to investigate the effects of the stem cell protein Piwil2 on MCF10A and MCF-7 at the GST activity levels.

Materials/Methods
MCF-7/Piwil2 and MCF10A/Piwil2, transfected with a plasmid carrying the Piwil2 gene, and non-transfected MCF-7 and MCF10A were cultured in a complete DMEM/F12 medium. GST A1 and P1 activity was determined in these cell lines using as substrates CDNB, EA respectively.

Results
According to experimental results, GST P1 activity decreased in the MCF-7/Piwil2 cells as compared with the non-transfected MCF-7 cells, however, MCF-7/Piwil2 cells demonstrated increases in GST A1 (total GST) activity. The statistically significant differences were found for the comparison of non-transfected MCF-7 and MCF-7/Piwil2 (p<0,0001), for GST enzyme activities by using CDNB and EA as substrates. These results were the same for the MCF10A cell line.

Discussion
It is shown for the first time that transfection studies may affect GST activity at the cellular mechanism level. The study contributes to determining the effect of transfection on GST isoenzymes and also how the Piwil2 gene may affect GST activity in the stem cell line.
The impact of the Covid-19 Pandemic on management and organisational related issues
Authors: McDonnell Anthony , Beck Matthias 
Published: April 2022

Abstract
While major crises are not uncommon, the rapid spread, scope and both health and economic devastation that Covid-19 brought makes it a unique opportunity in which to examine its impacts. This editorial introduces the five papers that encompass this special issue which focuses on the impact of the Covid-19 pandemic on management and organisational related issues. In this editorial, we situate the five papers within the Covid-19 context, synthesise the key contributions arising from each piece of work and provide a succinct, broad research agenda as individuals and organisations continue to navigate their way through and out of this global health crisis.
Identification of contractions from Electrohysterography for prediction of prolonged labor
Authors: Vasist Santosh N , Bhat Parvati , Ulman Shrutin , Hebbar Harishchandra 
Published: April 2022

Abstract
The analysis of the uterine electrical activity and its propagation patterns could potentially predict the risk of prolonged/arrested progress of labor. In our study, the Electrohysterography (EHG) signals of 83 participants in labor at around 3-4 cm of cervical dilatation, were recorded for about 30 minutes each. These signals were analyzed for predicting prolonged labor. Out of the 83 participants, 70 participants had normal progress of labor and delivered vaginally. The remaining 13 participants had prolonged/ arrested progress of labor and had to deliver through a cesarean section. In this paper, we propose an algorithm to identify contractions from the acquired EHG signals based on the energy of the signals. The role of contraction consistency and fundal dominance was evaluated for impact on progress of the labor. As per our study, the correlation of contractions was higher in case of normal progress of labor. We also observed that the upper uterine segment was dominant in cases with prolonged/arrested progress of labor.
Advances in the application of regenerative medicine in prevention of post-endoscopic submucosal dissection for esophageal stenosis
Authors: Wang Jiaxin , Zhao Yan , Li Peng , Zhang Shutian 
Published: April 2022

Abstract
Endoscopic submucosal dissection (ESD) is a curative treatment for superficial esophageal cancer with distinct advantages. However, esophageal stenosis after ESD remains a tough problem, especially after large circumferential proportion of esophageal mucosa is removed, which limits the wide use of ESD, especially in circumferential lesions. In this scenario, preventive procedures are highly recommended against post-ESD esophageal stenosis. However, the efficacy and safety of traditional prophylactic methods (steroids, metal and biodegradable stents, balloon dilation, radial incision, etc.) are not satisfactory and novel strategies need to be developed. Regenerative medicine has been showing enormous potential in the reconstruction of organs including the esophagus. In this review, we aimed to describe the current status of regenerative medicine in prevention of post-ESD esophageal stenosis. Cell injection, cell sheet transplantation, and extracellular matrix implantation have been proved effective. However, numerous obstacles still exist and further studies are necessary.