bluuebunny/crossref_metadata_2025_split huggingface dataset:
Spectral synthesis of multimode lasers to the Fourier limit in integrated Fabry–Perot diamond resonators
Authors: Granados Eduardo , Granados Camilo , Ahmed Rizwan , Chrysalidis Katerina , Fedosseev Valentin N. , Marsh Bruce A. , Wilkins Shane G. , Mildren Richard P. , Spence David J. 
Published: February 2022

Fourier-limited nanosecond pulses featuring narrow spectral bandwidths are required for applications in spectroscopy, sensing, and quantum optics. Here, we demonstrate a direct and simple route for the generation of single-frequency light relying on phonon-resonant Raman interactions within a monolithic diamond resonator. The technique enables the production of nearly Fourier-limited nanosecond optical pulses (15 ns), with an overall spectral bandwidth of down to 180 MHz, which is nearly two orders of magnitude narrower than the pump laser linewidth used (12 GHz). The power conversion efficiency was 47%, yielding a power spectral brightness enhancement of

>

50
×

compared to the pump. Our results pave the way to the integration of pulsed widely tunable, power scalable, narrow linewidth light sources into integrated photonic platforms. Furthermore, the device does not need elaborate mechanical feedback loops for cavity length or frequency stabilization, or any additional optical components.
Pediatric Chagas disease in the non-endemic area of Madrid: A fifteen-year review (2004–2018)
Authors: Bravo-Gallego Luz Yadira , Francisco-González Laura , Vázquez-Pérez Álvaro , García-López Hortelano Milagros , López Vélez Rogelio , González-Granado Luis Ignacio , Santos Mar , Epalza Cristina , Jiménez Ana Belén , Cilleruelo María José , Guillén Sara , Fernández Tania , Olabarrieta Iciar , Flores-Chavez María , Ramos Amador José Tomás , González-Tomé María Isabel 
Published: February 2022

Background
Chagas disease (CD) has become an emerging global health problem in association with the immigration of individuals from endemic areas (in LatinAmerica) to other countries.Spain is the country in Europe with the highest number of CD cases. Concerning pediatric CD, treatment is not only better tolerated by younger children but also has greater cure possibilities. The aim of this study was to describe clinical and epidemiological aspects of CD in a pediatric population diagnosed of 10 hospitals in the Community of Madrid during the 2004–2018 period, as well as the safety and efficacy of CD treatment on this population.

Methodology/Principal findings
A multicenter, retrospective, descriptive study was conducted. The studied population included all identified children under the age of 18 with a diagnosis of CD. Diagnosis was performed with a positive parasitological test (with subsequent confirmation) or confirmed persistence of positive serology beyond 9 months, for children younger than one year-old, and with two different positive serological tests, for children older than one.
Fifty-one children were included (59% male; 50.9% born in Spain). All mothers were from Latin America. The median age at diagnosis was 0.7 months for those under one year of age, and 11.08 years for those older than one year-old. Only one case presented a symptomatic course (hydrops faetalis, haemodynamic instability at birth, ascites, anaemia). For 94% treatment was completed. Considering patients who received benznidazole (47), AE were recorded in 48,9%. Among the 32 patients older than one year-old treated with benznidazole, 18 (56.25%) had adverse events whereas in the 15 under one year, 5(33,3%) did. Eigtheen (78.2%) of the patients with benznidazole AE were older than one year-old(median age 11.4 years). Of the patients treated with nifurtimox (9), AE were reported in 3 cases (33,3%).
Cure was confirmed in 80% of the children under one year-old vs 4.3% in those older (p<0.001). Loss to follow- up occurred in 35.3% of patients.

Conclusions/Significances
Screening programs of CD since birth allow early diagnosis and treatment, with a significantly higher cure rate in children treated before one year of age, with lower incidence of adverse events. The high proportion of patients lost to follow-up in this vulnerable population is of concern.
Wasp venom peptide improves the proapoptotic activity of alendronate sodium in A549 lung cancer cells
Authors: Alhakamy Nabil A. , Okbazghi Solomon Z. , A. Alfaleh Mohamed , H. Abdulaal Wesam , Bakhaidar Rana B. , Alselami Mohammed O. , Zahrani Majed AL , Alqarni Hani M. , F. Alghaith Adel , Alshehri Sultan , Badr-Eldin Shaimaa M. , Aldawsari Hibah M. , Al-hejaili Omar D. , Aldhabi Bander M. , Mahdi Wael A. 
Published: February 2022

BackgroundLung cancer in men and women is considered the leading cause for cancer-related mortality worldwide. Anti-cancer peptides represent a potential untapped reservoir of effective cancer therapy.MethodologyBox-Behnken response surface design was applied for formulating Alendronate sodium (ALS)-mastoparan peptide (MP) nanoconjugates using Design-Expert software. The optimization process aimed at minimizing the size of the prepared ALS-MP nanoconjugates. ALS-MP nanoconjugates’ particle size, encapsulation efficiency and the release profile were determined. Cytotoxicity, cell cycle, annexin V staining and caspase 3 analyses on A549 cells were carried out for the optimized formula.ResultsThe results revealed that the optimized formula was of 134.91±5.1 nm particle size. The novel ALS-MP demonstrated the lowest IC50 (1.3 ± 0.34 μM) in comparison to ALS-Raw (37.6 ± 1.79 μM). Thus, the results indicated that when optimized ALS-MP nanoconjugate was used, the IC50 of ALS was also reduced by half. Cell cycle analysis demonstrated a significantly higher percentage of cells in the G2-M phase following the treatment with optimized ALS-MP nanoconjugates.ConclusionThe optimized ALS-MP formula had significantly improved the parameters related to the cytotoxic activity towards A549 cells, compared to control, MP and ALS-Raw.
The effect of mothers and caregivers’ fasting status on the dietary diversity of children 6-23 months: A longitudinal study in Debrebirhan, Ethiopia
Authors: Armdie Addisalem Zebene , Fenta Esete Habtemariam , Shiferaw Solomon 
Published: February 2022

Background
There are various religions in Ethiopia, of which the Orthodox Tewahido Christian accounts for 44% of the population. According to the Ethiopian Orthodox Tewahido practice close to 200 days annually are dedicated to fasting. During this time, all followers who are above seven years old are expected to abstain from all types of food, including animal source foods and water for up to some hours daily. It is possible that such practice by mothers or caregivers could affect children’s dietary practice. However, whether mothers/caregivers’ fasting status influences dietary diversity of children during these periods remained uninvestigated.

Methods
A community-based longitudinal study was conducted in Debrebirhan, North Shewa Zone, Ethiopia in seven randomly selected kebeles. We collected data in a sample of 218 mothers/caregivers, from January 29 to February 25, 2019 in the pre-fasting period and from March 18 to April 10, 2019, during fasting period on same participants. Data was entered on Epi-Data version 4.4.2.1 and analyzed using STATA 15 software. Children’s dietary diversity was measured using the World Health Organization (WHO) standardized questionnaire for infant and young child feeding. The McNemar paired test was used for comparison of baseline and end line measurements. Statistical significance was set at p<0.05.

Result
A total of 218 and 216 mothers/caregivers with children 6–23 months participated in the study before and during fasting season with a response rate of 100.0% and 99.0% respectively. The median age of children was 14 months. The proportion of children who met the minimum dietary diversity before the fasting season was significantly higher (23.4%) compared to during the fasting period (5.5%). (P<0.001). The proportion of children who consumed dairy product was significantly higher (55.5%) before the fasting period compared to consumption during the fasting period (42.6%) (p<0.001). Similarly, consumption of flesh food was significantly higher before the fasting period (17.9%) compared to consumption during the fasting period (0.46%) (P<0.001).

Conclusion
The study revealed that mothers/caregivers’ fasting status negatively affect the dietary diversity of children aged 6–23 months in the household by decreasing their consumption of animal source food. Intervention strategies in promoting children’s dietary diversity should be designed in a way that considers Ethiopian Orthodox Tewahido Christian mothers/caregivers’ fasting practice.
Predictors of time to death among cervical cancer patients at Tikur Anbesa specialized hospital from 2014 to 2019: A survival analysis
Authors: Seifu Benyam , Fikru Chaltu , Yilma Delelegn , Tessema Fasil 
Published: February 2022

Background
Cervical cancer (CC) is the 4th most prevalent cancer among females globally. In Ethiopia, around 7,095 new CC cases are diagnosed every year and it is the second common cause of cancer deaths in women. There is limited evidence on survival status as well as about predictors of time to death among CC patients in Ethiopia. Thus, this study investigated the five-year survival status and predictors of time to death among CC patients who had been admitted at Tikur Anbesa specialized Hospital (TASH) from 2014–2019.

Methods
Facility-based, retrospective-cohort study was conducted at Tikur Anbesa specialized Hospital among 348 patients from June 2014 to June 2019. A systematic random sampling method was employed to select the study participants. Data were extracted from the patient card, and through phone calls. The data was collected using the android version CS-Entry tool. Data was analyzed by SPSS version 23. Kaplan and Meier’s method was used to estimate survival functions and Cox-proportional hazard regression analysis was carried out in order to identify the independent predictors of time to death.

Results
The overall incidence of death was 31 per 100 person-years of follow up. The median (IQR) follow-up time of the entire cohorts was 18.55 (8.96–49.65) months. The independent predictors for time to death included; age older than 50 years [AHR: 1.4; 95% CI: 1.1–1.9], late stage of CC at diagnosis [AHR: 2.2; 95% CI: 1.7–2.9], No CC treatment [AHR: 2.1; 95% CI: 1.5–3.1] and HIV positive [AHR: 2.3; 95% CI: 1.4–3.8].

Conclusion and recommendation
The death rate of CC patients was high. The significant predictors associated with shorten time to death of CC patients were older age, advanced cancer stage at diagnosis, HIV infection and not receiving cancer treatment. Therefore, improving early detection and initiation of treatment for all CC patients is necessary in order to improve patient’s survival status. The government needs to strengthen the routine CC screening programs to address high-risk women such as elderly and HIV positive women in Ethiopia.
DEVELOPMENT MANAGEMENT OF INDUSTRIAL ENTERPRISE
Authors: Konovalov M. V. , Tsomaeva I. V. , Kiseleva A. A. 
Published: February 2022

During strategy development and implementation industrial enterprises face conceptual difficulties, that are similar for enterprises of the military-industrial complex due to their institutional, industry and integration characteristics. The article proposes a methodological approach to the strategic management process organization with an emphasis on the implementation stage of strategic development. Also, modern operating concepts, mechanisms and tools for enterprise development management are considered. Current requirements are highly important. Documents regulating the development management business process must comply with the principles of a quality management system (QMS), and mechanisms for analyzing large amounts of information should correspond to the procedure of mathematical modeling, neuroinformatics, hybrid expert systems, adapted at enterprises during previous empirical research.
It is recommended to make employee reward system concern the level of implementation of company’s development projects.
INSTITUTIONAL AND ECONOMIC ASPECTS OF LABOR FORCE REPRODUCTION FROM THE PERSPECTIVE OF POSITIVE AND NORMATIVE APPROACHES
Authors: Krishka V. I. , Perekarenkova Yu. A. 
Published: February 2022

The article shows that the traditional opposition of positive and normative approaches to each other is incorrect, since in reality the positive (positive) approach is opposed to the negative (negative) approach. The normative approach in the field of economics is in contradictory unity with the real measure of economic processes as their subjective, regulatory side associated with the establishment of rules of economic activity.
As a result of the analysis, it was revealed that the reproduction of the commodity form of labor force as a whole includes four types: a) the production of goods through goods, b) the production of people through people, c) the production of knowledge through knowledge, and d) the production of man himself as human capital.
In the modern economy, a complex two-way process, which, on the one hand, frees workers from performing heavy and routine operations, and, on the other hand, creates prerequisites for changing the target function of the economy, its real measure: that is, the transition from the production of material wealth to the production of their own human wealth associated with human capital.
The development of human capital based on the growth of labor potential and the complexity of the work performed is a kind of “demand of the time” and involves the revival of the institution of labor rationing in the broadest sense, including both economic and institutional aspects.
Flood Modeling on Koya Catchment Area Using Hyfran, Web Map Service, and HEC-RAS Software
Authors: Dawood Anwer H. , Mawlood Dana K. , Al-Ansari Nadhir 
Published: February 2022

In this research, The boundaries of the Koya catchment area have been delineated, and valley paths in the region were drawn by using the Water Modeling System (WMS) software, Analysis of the morphometric information indicated that the morphometric characteristics of watersheds contribute to the floods. The average surface runoff depth depends on the curve number values that are determined based on the types of soil cover and soil class according to Harmonized World Soil Database HWSD software that indicates the soil class in the study area are Group B silt loam, The results obtained also show that the potential for surface runoff varies with land use and soil characteristics. Also, the value of the curve number (CN) was determined to be 71. The hydrological modeling was performed by the HEC-HMS program that simulates the process of rainfall to runoff using the SCS curve number model. A flood hydrograph was constructed at the catchment area outlet and the floodplain delineation was verified by the HEC-RAS software. The results indicated that the 100-year return period flood could Reach critical areas such as the urban area, agricultural area, residential areas. the results of this study indicate that there are suitable sites in the catchment areas for constructing small dams and ponds for water harvesting.
Transnarodowy modernizm a problem temporalnej spacjalizacji w Budowie chińskiego muru Franza Kafki
Authors: Sriratana Verita 
Published: February 2022

Zazwyczaj przyjmuje się, że czas postrzegany może być tylko w kategoriach przestrzennych i że spacjalizacja czasu, uzależniając go ściśle od tego, co materialne, ogranicza moc jego abstrakcyjności lub wirtualności. Literatura modernistyczna, tak jak zwykle ją się rozumie, przyswaja ten paradygmat, sugerując jednocześnie, że również przestrzeń tłumaczyć można w kategoriach czasowych, temporalizacja przestrzeni dekonstruuje fasadę trwałych oraz skodyfikowanych znaczeń przestrzennych. Derrida definiuje tę czasoprzestrzenną (inter)reakcję i logiczną współznaczenie jako „rozsunięcie” (espacement). Niemniej jednak analizy czasu i czasowości, jak również przestrzeni/miejsca i przestrzenności w twórczości modernistycznej często wpadają w pułapkę z powodu problemu czasowego następstwa, a następnie z powodu błędnego przekonania, że przestrzeń jest nieruchoma. Problem następstwa znajduje się w przekonaniu, że czas płynie i przestaje być natychmiast(owy), pozostawiając po sobie tylko Derriański „ślad”, który jest przestrzenny. Pojęcie to jest problematyczne, ponieważ opiera się na implikacjach, że przestrzeń jest nieruchoma i pasywna, wbrew temporalnej „rozsunięcie” czy temporalnemu następstwu, i że ślady czasu są w niej biernie odciśnięte. Dowodzę, że przestrzeń daleka jest od nieruchomości i pasywności. Jej dynamika czyni spacjalizację czasu problematyczną. Opowiadanie Franza Kafki „Budowa Chińskiego Muru” (napisane w 1917 roku) jest dobrym przykładem modernistycznej twórczości, która nie tylko problematyzuje pojęcia czasu i czasowości oraz przestrzeni i przestrzenności, ale stawia w centrum problem spacjalizacji czasu.
Research on Performance of Natural Rubber Latex Composite–Modified Asphalt
Authors: Cao Dongwei , Tan He , Yang Zhe , Chen Huaxin , Kuang Dongliang 
Published: February 2022

Abstract
Natural rubber latex (NRL) is a polymer material collected from rubber trees with polyisoprene as the main component, which is a sustainable renewable material. With many excellent physical properties, it has been used to modify petroleum asphalt for paving roads very early to improve the performance of asphalt and asphalt mixtures. In order to prepare a modified asphalt with good comprehensive performance, this paper mixes NRL and styrene-butadiene-styrene (SBS) latex to prepare a composite-modified asphalt and conducts the experimental test of the penetration grading system and the experimental test of the rheological index. To obtain a modified asphalt with good comprehensive performance, NRL and SBS latex are mixed in this study to prepare a composite-modified asphalt, and the penetration grading system and rheological index are tested experimentally. The experimental results show that the addition of NRL and SBS latex significantly improves the anti-aging performance of asphalt. Fluorescence microscopy observations show that when the ratio of NRL latex to SBS latex is 1:1 to 1:2, the microstructure of the modified asphalt appears as a bicontinuous phase that interpenetrates the asphalt and latex phases and forms a stable grid. The rutting experiment and low-temperature trabecular bending experiments show that both the high- and low-temperature performance of the NRL/SBS latex composite–modified asphalt mixture improve greatly compared with that of NRL latex–modified asphalt mixture. Furthermore, the water immersion Marshall test and freeze–thaw splitting test show that the NRL-modified asphalt mixture has good resistance to water damage.
Thermal Rebreathing Model for Evaluation of Infant Bedding Materials
Authors: Leshner Michael D. 
Published: February 2022

Abstract
Carbon dioxide (CO2) rebreathing is a recognized hazard, particularly for infants. A new thermal rebreathing method and apparatus have been developed for measuring and comparing the degree to which various soft bedding materials perform with respect to this hazard. The new methodology simplifies the evaluation process and uses less costly equipment than the incumbent expensive and complex CO2 rebreathing model. Using warm air as a proxy for CO2, it relies on a highly sensitive differential thermometer to measure air temperature differences that correlate to the level of rebreathing. The apparatus is portable and requires neither the use of a gas analyzer nor a source of CO2. Test results comparing the two methods show strong correlation validating the new thermal concept. The availability of a simple CO2 rebreathing method and apparatus will promote quantitative evaluation of this hazard among a wider group of users, including infant product developers and manufacturers. Additional studies are suggested to further develop the thermal rebreathing model.
Revisiting the Music-Printing Market in Seventeenth-Century Italy and the Peculiar Case of Pietro Millioni’s Guitar Books
Authors: Brettler Gideon 
Published: February 2022

This article examines the Italian music-printing industry in the seventeenth century from two distinct perspectives. The first revisits the industry’s decline and the circumstances that led to that state of affairs. The second traces the unlikely commercial success of the guitar tutors of Pietro Millioni, offering a glimpse into the inner workings of the industry. A quantitative analysis of production patterns using a newly constructed database of seventeenth-century Italian music prints provides a nuanced view of the rise and fall in output across various printing centers. Cross-referencing these data with an analysis of the corpora of the leading printing houses of Venice and Rome exposes various idiosyncrasies of these two centers of music printing and suggests that the downturn in production was driven not only by domestic conditions but also by the gradual decline of Venice as a dominant international economy.
The music in the Millioni books is printed with an idiomatic notation for the guitar known as alfabeto. The simplicity of alfabeto notation offered the musically illiterate an accessible path to music making, while its typographical features offered printers a cheap and easy method of printing music without specialized equipment or expertise. The continued success of these books in a contracting market demonstrates the significant appeal of this music for both printer and consumer, which contributed to the codification of oral musical traditions in print. The reconstruction of the genealogy of the Millioni books discloses numerous commercial ties between publishers, as well as their influence over musical content.
PENERAPAN MODEL PEMBELAJARAN KOOPERATIF TIPE THINK PAIR SHARE (TPS) UNTUK MENINGKATKAN AKTIVITAS DAN KETUNTASAN BELAJAR SISWA
Authors: Arlinah Euis Ani 
Published: February 2022

The inability of most students to solve a problem shows that students do not understand the concepts taught by the teacher in learning activities, the skills to solve a problem individually and collaboratively, students need to be directed to an understanding, one of which is by determining the learning model, the cooperative learning model type Think Pair Share (TPS) is a learning model that can increase the effectiveness of students' psychomotor learning. The results showed that: (a) most of the students gave a positive response to the application of the TPS type cooperative learning model, (b) the results of observations showed that most of the students could be active in the learning process, (c) the results of the formative and summative tests showed that the students experience an increased level of completeness, (d) the TPS type cooperative learning model can increase student learning activities and mastery.
Ketidakmampuan sebagian besar siswa dalam memecahkan suatu permasalahan memperlihatkan bahwa siswa belum memahami konsep yang diajarkan guru dalam kegiatan pembelajaran, keterampilan memecahkan suatu permasalahan secara individu dan bekerjasama, siswa perlu diarahkan kepada suatu pemahaman, salah satunya dengan menentukan model pembelajaran, model pembelajaran kooperatif tipe Think Pair Share (TPS) merupakan sebuah model pembelajaran yang dapat meningkatkan efektivitas belajar psikomotorik siswa. Hasil penelitian menunjukkan bahwa : (a) sebagian besar siswa memberikan respon yang positif terhadap penerapan model pembelajaran kooperatif tipe TPS, (b) hasil observasi menunjukkan sebagian besar siswa dapat beraktivitas dalam proses pembelajaran, (c) hasil tes formatif dan tes sumatif menunjukkan bahwa siswa mengalami tingkat ketuntasan yang meningkat, (d) model pembelajaran kooperatif tipe TPS dapat meningkatkan aktivitas dan ketuntasan belajar siswa.