bluuebunny/crossref_metadata_2025_split huggingface dataset:
The first canid from the Gray Fossil Site in Tennessee: new perspective on the distribution and ecology ofBorophagus
Authors: Bōgner Emily , Samuels Joshua X. 
Published: July 2022

AbstractBorophagusis the terminal genus of the highly diverse and successful subfamily, Borophaginae. Skeletal remains of this bone-crushing canid are most commonly found in transitional or grassland environments across North America between Late Miocene–Middle Pleistocene, but are rare or absent in forested habitats. Here, we describe a humerus from the Gray Fossil Site of Tennessee, which is the first occurrence of this genus in a heavily forested ecosystem. The distinct limb proportions ofBorophagussuggest the genus may have been well suited for a closed habitat like the Gray Fossil Site, contrary to where a majority of their fossils have been previously found. This discovery documents the first pre-Pleistocene occurrence of a canid in the Appalachian region of the eastern United States.
α-Synuclein-induced deformation of small unilamellar vesicles
Authors: Makasewicz Katarzyna , Wennmalm Stefan , Linse Sara , Sparr Emma 
Published: July 2022

Abstract
α-Synuclein is a small neuronal protein that reversibly associates with lipid membranes. The membrane interactions are believed to be central to the healthy function of this protein involved in synaptic plasticity and neurotransmitter release. α-Synuclein has been speculated to induce vesicle fusion as well as fission, processes which are analogous to each other but proceed in different directions and involve different driving forces. In the current work, we analyse α-synuclein-induced small unilamellar vesicle deformation from a thermodynamics point of view. We show that the structures interpreted in the literature as fusion intermediates are in fact a stable deformed state and neither fusion nor vesicle clustering occurs. We speculate on the driving force for the observed deformation and put forward a hypothesis that α-synuclein self-assembly on the lipid membrane precedes and induces membrane remodelling.
Relationships between the serum TPOAb and TGAb antibody distributions and water iodine concentrations, thyroid hormones and thyroid diseases: a cross-sectional study of 2503 adults in China
Authors: Zhou Zheng , Liu Lixiang , Jin Meihui , Ren Bingxuan , Meng Fangang , Wang Dandan , Li Jianshuang , Li Baoxiang , He Yanhong , Li Fan , Shen Hongmei 
Published: July 2022

AbstractThe aim of this study was to explore the status of thyroid peroxidase antibody (TPOAb) and thyroglobulin antibody (TGAb) in three areas with differing water iodine concentrations; and to discuss the relationships between these two thyroid antibodies and thyroid diseases in the three areas. We investigated 2503 adults from three areas. Urinary iodine concentrations, thyroid stimulating hormone (TSH), free thyroxine (FT4), free triiodothyronine (FT3), TPOAb, TGAb and thyroid volume (TV) were measured, and thyroid ultrasonography was performed. The positivity rates of TGAb(+), TPOAb(+) and TGAb(+) and TPOAb(+) or TGAb(+) were significantly higher in iodine fortification (IF) areas than iodine adequate (IA) areas (all P < 0·05). In IF and iodine excess areas, the positivity rates of TPOAb(+), TGAb(+) and TPOAb(+) or TGAb(+) significantly increased with age (all P for trend < 0·05). The levels of TSH, TV and the prevalence of overt hypothyroidism, subclinical hypothyroidism and goitre were significantly elevated in the thyroid antibody-positive groups in the three areas, but the FT3 was diminished (all P < 0·010). Positivity for TPOAb and TGAb was associated with an increased risk of subclinical hypothyroidism in the three areas. In areas with different median water iodine, positivity for both TPOAb and TGAb was associated with elevated TSH values. Notably, with the increased levels of TPOAb, the frequency of abnormally elevated TSH increased dramatically in the three areas.
Data-driven similar response units for agricultural technology targeting: An example from Ethiopia
Authors: Tamene Lulseged , Abera Wuletawu , Bendito Eduardo , Erkossa Teklu , Tariku Meklit , Sewnet Habtamu , Tibebe Degefie , Sied Jemal , Feyisa Gudina , Wondie Menale , Tesfaye Kindie 
Published: July 2022

Abstract
Ethiopia has heterogeneous topographic, climatic and socio-ecological systems. Recommendations of agricultural inputs and management practices based on coarse domains such as agro-ecological zones (AEZ) may not lead to accurate targeting, mainly due to large intra-zone variations. The lack of well-targeted recommendations may contribute to the underperformance of promising technologies. Therefore, there is a need to define units where similar environmental and biophysical features prevail, based on which specific recommendations can be made for similar response units (SRUs). We used unsupervised machine learning algorithms to identify areas of high similarity or homogeneous zones called ‘SRUs’ that can guide the targeting of agricultural technologies. SRUs are landscape entities defined by integrating relevant environmental covariates with the intention to identify areas of similar responses. Using environmental spatial data layers such as edaphic and ecological variables for delineation of the SRUs, we applied K- and X-means clustering techniques to generate various granular levels of zonation and define areas of high similarity. The results of the clustering were validated through expert consultation and by comparison with an existing operational AEZ map of Ethiopia. We also augmented validation of the heterogeneity of the SRUs by using field-based crop response to fertiliser application experimental data. The expert consultation highlighted that the SRUs can provide improved clustering of areas of high similarity for targeting interventions. Comparison with the AEZ map indicated that SRUs with the same number of AEZ units captured heterogeneity better with less within-cluster variability of the former. In addition, SRUs show lower within-cluster variability to optimal crop response to fertiliser application compared with AEZs with the same number of classes. This implies that the SRUs can be used for refined agricultural input and technology targeting. The work in this study also developed an operational framework that users can deploy to fetch data from the cloud and generate SRUs for their areas of interest.
A Literature Review on the Impact of Wildfires on Emergency Departments: Enhancing Disaster Preparedness
Authors: Skinner Richard , Luther Matt , Hertelendy Attila J. , Khorram-Manesh Amir , Sørensen Jarle , Goniewicz Krzysztof , Ranse Jamie 
Published: July 2022

AbstractIntroduction:Global climate change (global warming) has been identified as the primary factor responsible for the observed increase in frequency and severity of wildfires (also known as bushfires in some countries) throughout the majority of the world’s vegetated environments. This trend is predicted to continue, causing significant adverse health effects to nearby residential populations and placing a potential strain on local emergency departments (EDs).Study Objective:The aim of this literature review was to identify papers relating to wildfires and their impact on EDs, specifically patient presentation characteristics, resource utilization, and patient outcomes.Method:This integrative literature review was guided by the Preferred Reporting Items of Systematic Reviews and Meta-Analysis (PRISMA) guidelines for data collection, and Whittemore and Knafl’s framework for data analysis. Data were collected from OvidSP, MEDLINE, DARE, CINAHL, PubMed, and Scopus databases. Various Medical Subject Headings (MeSH) and keywords identified papers relevant to wildfires/bushfires and EDs.Results:Literature regarding the relationship between ED presentations and wildfire events, however, is primarily limited to studies from the United States and Australia and indicates particulate matter (PM) is principally linked to adverse respiratory and cardiovascular outcomes. Observable trends in the literature principally included a significant increase in respiratory presentations, primarily with a lag of one to two days from the initial event. Respiratory and cardiovascular studies that stratified results by age indicated individuals under five, over 65, or those with pre-existing conditions formed the majority of ED presentations.Conclusion:Key learnings from this review included the need for effective and targeted community advisory programs/procedures, prior to and during wildfire events, as well as pre-event planning, development, and robust resilience strategies for EDs.
Applying the Haddon Matrix to Frontline Care Preparedness and Response in Asymmetric Warfare
Authors: Salio Flavio , Pirisi Alessandro , Ciottone Gregory R. , Echeverri Lina Maria , Peleg Kobi , Redmond Anthony D. , Weinstein Eric S. , Hubloue Ives , Della Corte Francesco , Ragazzoni Luca 
Published: July 2022

AbstractIntroduction:Asymmetric warfare and the reaction to its threats have implications in the way far-forward medical assistance is provided in such settings. Investments in far-forward emergency resuscitation and stabilization can contribute to saving lives and increase the resilience of health systems. Thus, it is proposed to extend the use of the Haddon Matrix to determine a set of strategies to better understand and prioritize activities to prepare for and set-up frontline care in the form of Trauma Stabilization Points (TSPs).Methods:An expert consensus methodology was used to achieve the research aim. A small subject matter experts’ group was convened to create and validate the content of the Haddon Matrix.Results:The result of the expert group consultations presented an overview of TSP Preparedness and Operational Readiness activities within a Haddon Matrix framework. Main strategies to be adopted within the cycle from pre- to post-event had been identified and presented considering the identified opportunities in the context of the possibility of implementation. Of particular importance was the revision of a curriculum that fits the civilian medical system and facilitates its adaptation to the context and available resources.Conclusion:The new framework to enhance frontline care preparedness and response using the Haddon Matrix facilitated the identification of a set of strategies to support frontline health care workers in a more efficient manner. Since the existing approach and tools are insufficient for modern warfare, additional research is needed.
Should wages be subsidized in a pandemic?
Authors: Abbott Brant , Phan Nam Van 
Published: July 2022

AbstractWe use a labor search model with heterogenous households and firms to study the efficacy of a wage subsidy during a pandemic, relative to enhancing unemployment benefits. A large proportion of the economy is forced to shut down, and firms in that sector choose whether to lay off workers or keep them on payroll. A wage subsidy encourages firms to keep workers on payroll, which speeds up labor market recovery after the pandemic ends. However, a wage subsidy can be costlier than enhancing unemployment benefits. If the shutdown is long or profit margins are low, then a wage subsidy is preferable and vice versa. The optimal mixture of policies includes a wage subsidy that covers 90
$\%$
of the first $200/week of earnings and expands unemployment benefits to cover all salary up to $275/week. Low-income workers, as well as those in less productive jobs, benefit the most from a wage subsidy.
Coping with suicide loss: a qualitative study in primary health care
Authors: Suija Kadri , Rooväli Liis , Aksen Merli , Pisarev Heti , Uusküla Anneli , Kiivet Raul-Allan 
Published: July 2022

Abstract

Aim:
To analyze how people cope with suicide loss and the implications for primary health care.

Background:
Previous studies have shown that primary health care will often be an initial source of support for those bereaved by suicide.

Methods:
We included adult persons who were ready to talk about a suicide completed by a person they knew well (family member or close friend). Participants were recruited via mixed media (television, radio, print, social media, etc.). Altogether, we conducted 37 individual interviews, which were recorded using a dictaphone and lasted from 46 to 158 min. The interviews were transcribed verbatim and analyzed using a content analysis method. The interviewees were mostly women (n = 27) and family members (n = 28) of a person who had died by suicide during the years 2012–2018.

Findings:
We identified two main themes in the data: supporters and barriers in support. Coping with suicide takes time, and support was mostly found among friends and family. Support from GPs was mentioned in the context of diagnosing medical problems and prescribing medicines. Respondents indicated that feeling ashamed and a lack of trust impeded their willingness to seek help from their GP. Unmet needs among the bereaved may increase their risk of diminished mental health outcomes. Thus, primary health care practitioners may have a substantial opportunity to support those who are bereaved by suicide.

Conclusion:
Primary care providers have an opportunity to provide bereavement support among their patients. Continuing medical education regarding the needs of the bereaved and a coordinated approach among primary care practitioners may be useful to proactively identifying and supporting those in need.
International Networking in Russian Music Theatre around 1800: Sheremetev, Yusupov and Grand Duke Pavel Petrovich
Authors: Giust Anna 
Published: July 2022

This article investigates the role played by aristocrats in the exchange of repertoire and musical personnel between Russia and Western Europe in the late eighteenth and early nineteenth centuries. It discusses the involvement of three significant figures in the political and cultural milieus of the Russian Empire: Count Nikolay Petrovich Sheremetev (1751–1809), Prince Nikolay Borisovich Yusupov (1750–1831) and the Grand Duke Pavel Petrovich Romanov (who ruled as Paul I from 1796 to 1801). The central focus is on Sheremetev, whose correspondence with Marie-François Hivart, a Parisian cellist he met during a grand tour, allows us to reconstruct a clear picture of how French opera was imported and adapted at his estate theatres in the Moscow area. Yusupov and the grand duke likewise established international musical contacts during their European tours of the 1770s and 80s, and exploited them in their private and public theatrical activities in Russia. Yusupov, who was particularly fond of Italian opera, may be regarded as Sheremetev's counterpart in St Petersburg, while Tsarevich Pavel Petrovich channelled the musical contacts he established in Italy to the Russian court and crown theatres.Together, these cases suggest some of the ways in which Russia was entangled in European musical life around 1800, revealing mechanisms of exchange in which grand tours, diplomatic contacts and the personal interests of patrons played a significant part.
Contesting Freedom of Information: Capitalism, Development, and the Third World
Authors: CONG Wanshu 
Published: July 2022

AbstractThis paper historicizes the current challenges brought about by digitization to the Third World by revisiting a movement launched by the Non-Aligned Movement countries during the 1970s and early 1980s. Also known as the New World Information and Communication Order (NWICO), the movement contested the dominant liberal notion of freedom of information and spotlighted the critically material inequality and power asymmetry often concealed by the liberal vision of the free flow of information. Not only did NWICO present a counter-model to the liberal notion of freedom of information, it also provides a vital case for understanding the interrelations between information and domination and the role of international law therein. This paper retells the story of NWICO, its normative ambition as well as its internal contentions and practical limitations, and reflects on its legacy for TWAIL scholarship and the current politics of digitization.
Competing Effects of Eastern and Central‐Western Pacific Winds in the Evolution of the 2017 Extreme Coastal El Niño
Authors: Zhao Sen , Karamperidou Christina 
Published: July 2022

AbstractIn this study, we investigate the relative contributions of dynamical forcings, particularly the eastern and central‐western Pacific winds, and thermodynamical forcings to the evolution of the 2017 extreme coastal El Niño using observations and modeling experiments. We show that the competing effects of anomalous eastern Pacific westerlies and central‐western Pacific easterlies and their resulting downwelling and upwelling equatorial Kelvin waves are essential for the evolution of the event, together with alongshore anomalous northerlies which suppress coastal upwelling and reduce latent heat release as discussed in previous studies. We find that eastern Pacific zonal wind anomalies are about twice as effective in generating a coastal response as central‐western Pacific anomalies, thus compensating for their usually smaller magnitude. While the 2017 event exemplified these competing effects, they were also found to be important in other coastal and basin‐scale El Niño events, thus contributing to the mechanisms responsible for El Niño diversity.
Geologic Heterogeneity Controls on Trapping and Migration of CO2
Authors: Krishnamurthy Prasanna G. , DiCarlo David , Meckel Tip 
Published: July 2022

AbstractWhen CO2 is injected into sedimentary basins, the fate of the buoyant CO2 will be determined by how it interacts with the underlying geologic heterogeneities. Here we geologically print a cross‐bedded pattern using two different bead sizes, and then conduct flow experiments to observe buoyant flow pathways, migration speed, and immobilized volumes. The amount of buoyant phase trapped under the heterogeneities is observed to vary by two orders of magnitude, with the controlling parameter being the size contrast between the coarse and fine grains that make up the structure. The results allow an estimate of heterogeneity trapping, and show how CO2 trapping in aquifers can be experimentally evaluated before injection.
Effects of a palaeolithic diet on obstructive sleep apnoea occurring in females who are overweight after menopause—a randomised controlled trial
Authors: Franklin Karl A. , Lindberg Eva , Svensson Johan , Larsson Christel , Lindahl Bernt , Mellberg Caroline , Sahlin Carin , Olsson Tommy , Ryberg Mats 
Published: July 2022

Abstract
Background/Objectives
Obesity is the main risk factor for obstructive sleep apnoea, commonly occurring in females who are overweight after menopause. We aimed to study the effect of a palaeolithic diet on sleep apnoea in females with overweight after menopause from the population.

Methods
Seventy healthy, non-smoking females with a mean age of 60 years and a mean BMI of 33 kg/m2 were randomised to a palaeolithic diet or to a control low-fat diet according to Nordic Nutritional Recommendations, for 2 years. The apnoea-hypopnoea index was measured and daytime sleepiness was estimated during the intervention.

Results
The mean apnoea-hypopnoea index at baseline was 11.6 (95% CI 8.6–14.5). The mean weight loss was 7.2 kg (95% CI 5.3–9.2 kg) in the palaeolithic diet group and 3.9 kg in the control group (95% CI 1.9–5.9 kg); p < 0.021 for the group difference. The reduction in weight corresponded to a reduction in the apnoea-hypopnoea index in the palaeolithic diet group (r = 0.38, p = 0.034) but not in the control group (r = 0.08, p = 0.69). The apnoea-hypopnoea index was reduced in the palaeolithic diet group when the weight was reduced by more than 8 kg. Daytime sleepiness according to the Epworth Sleepiness Scale score and the Karolinska Sleepiness Scale score was unaffected by dietary group allocation.

Conclusions
A substantial decrease in body weight of 8 kg was needed to achieve a reduction in sleep apnoea in this small trial of women who are overweight after menopause. The palaeolithic diet was more effective for weight reduction than a control low-fat diet and the reduction in sleep apnoea was related to the degree of weight decrement within this diet group.

Trial registration
Clinicaltrials.gov: NCT00692536.
Extending the PAX1 spectrum: a dominantly inherited variant causes oculo-auriculo-vertebral syndrome
Authors: Carter Shannon , Fellows Bridget J. , Gibson Kate , Bicknell Louise S. 
Published: July 2022

AbstractOculo-auriculo-vertebral syndrome (OAVS) is a clinically heterogeneous disorder, with both genetic and environmental contributors. Multiple genes have been associated with OAVS and common molecular pathways, such as retinoic acid and the PAX-SIX-EYA-DACH (PSED) network, are being implicated in the disease pathophysiology. Biallelic homozygous nonsense or hypomorphic missense mutations inPAX1cause otofaciocervical syndrome type 2 (OTFCS2), a similar but more severe multi-system disorder that can be accompanied by severe combined immunodeficiency due to thymic aplasia. Here we have identified a multi-generational family with mild features of OAVS segregating a heterozygous frameshift inPAX1. The four base duplication is expected to result in nonsense-mediated decay, and therefore cause a null allele. While there was full penetrance of the variant, expressivity of facial and ear features were variable. Our findings indicate there can be monoallelic and biallelic disorders associated withPAX1, and further implicate the PSED network in OAVS.
Competing electronic states emerging on polar surfaces
Authors: Reticcioli Michele , Wang Zhichang , Schmid Michael , Wrana Dominik , Boatner Lynn A. , Diebold Ulrike , Setvin Martin , Franchini Cesare 
Published: July 2022

AbstractExcess charge on polar surfaces of ionic compounds is commonly described by the two-dimensional electron gas (2DEG) model, a homogeneous distribution of charge, spatially-confined in a few atomic layers. Here, by combining scanning probe microscopy with density functional theory calculations, we show that excess charge on the polar TaO2 termination of KTaO3(001) forms more complex electronic states with different degrees of spatial and electronic localization: charge density waves (CDW) coexist with strongly-localized electron polarons and bipolarons. These surface electronic reconstructions, originating from the combined action of electron-lattice interaction and electronic correlation, are energetically more favorable than the 2DEG solution. They exhibit distinct spectroscopy signals and impact on the surface properties, as manifested by a local suppression of ferroelectric distortions.
Decrease in air-sea CO2 fluxes caused by persistent marine heatwaves
Authors: Mignot Alexandre , von Schuckmann Karina , Landschützer Peter , Gasparin Florent , van Gennip Simon , Perruche Coralie , Lamouroux Julien , Amm Tristan 
Published: July 2022

AbstractRegional processes play a key role in the global carbon budget. Major ocean CO2 uptake at mid-latitudes counteracts CO2 release in the tropics, which is modulated by episodes of marine heatwaves. Yet, we lack essential knowledge on persistent marine heatwaves, and their effect on the CO2 sensitive areas. Here we show, using a 1985–2017 joint analysis of reconstructions, ocean reanalysis and in situ and satellite data, that persistent marine heatwaves occur in major CO2 uptake and release areas. Average air-sea CO2 flux density changes from persistent marine heatwaves are strongest in the Pacific Ocean with a 40 ± 9% reduction in CO2 release in the tropics linked to ENSO, and a reduction in CO2 uptake of 29 ± 11% in the North Pacific over the study period. These results provide new insights into the interplay of extreme variability and a critical regulating ocean ecosystem service, and pave the way for future investigations on its evolution under climate change.