bluuebunny/crossref_metadata_2025_split huggingface dataset:
Relationship between the position and intensity of Low-Level Jet stream and Indian summer monsoon rainfall
Authors: Purwar Smrati , Rakesh V , Bankar Ajay , Mohapatra GN 
Published: May 2022

Abstract
A strong equatorial Low-Level Jet (LLJ) exists over the Indian Ocean plays a crucial role in modulating the Indian Summer Monsoon Rainfall (ISMR). The variation in strength and height of Monsoon LLJ (MLLJ) can provide an important lead in predicting the variations in ISMR. The variability of MLLJ is examined using the fifth generation ECMWF (European Centre for Medium-Range Weather Forecasts) reanalysis ERA-5, National Centers for Environmental Prediction-Climate Forecast System Reanalysis (NCEP-CFSR) / Climate Forecast System, version 2 (CFSv2) and the Modern-Era Retrospective Analysis for Research and Application, version-2 (MERRA-2) during 40 years period (1979–2018). The results suggest that there is an increasing trend in MLLJ strength during July and September, but a decreasing trend during August. The MLLJ level showed an upward trend (increase in height from the surface level) in all the reanalysis data sets. The ISM rainfall over Western Ghats region and central India showed strong positive (and negative) correlation with the MLLJ strength (and height) except during August. It is noted that the influence of the MLLJ on rainfall over the Indian subcontinent is stronger during the onset and withdrawal phases of monsoon. The increasing trend in MLLJ height indicated the possibility of increase in rainfall over many regions in India especially Western Ghat and Central India. The relationship between MLLJ strength and level with ISMR is strongest during the month of September. Our analysis also showed that lag correlation between MLLJ and ISMR is relatively weaker when compared to zero lag correlations.
Inter-seasonal connection of typical European heatwave patterns to soil moisture
Authors: Felsche Elizaveta , Böhnisch Andrea , Ludwig Ralf 
Published: May 2022

Abstract
This study aims to increase the general understanding and predictability of heatwaves by identifying and analyzing stable classes, i.e., recur- ring patterns, of heatwaves present in Europe. In this study, we use data from a regional climate model large ensemble (Canadian Regional Climate Model version 5, CRCM5-LE) consisting of 50 possible real- izations of climate in the years 1981-2010 for a Central European domain with a spatial resolution of 0.11◦. We find nine stable heat- wave patterns in Europe, which correspond well with clusters derived from an observational dataset (E-OBS) and extreme historical heat- wave events. We show that historical extreme events can be explained by a dominant manifestation of the same recurring pattern. More- over, we analyze the occurrence of heatwaves in the identified clusters regarding a soil moisture deficit present before and after the event. We show that soil moisture anomalies in preceding winter/spring (JFMA) can serve as a predictor for heatwaves in South Europe. For North Europe we find a negative correlation between the number of heatwave days in summer and autumn (OND) soil moisture anomaly.
Mineralocorticoids induce polyuria by reducing apical aquaporin-2 expression of the kidney in partial vasopressin deficiency
Authors: Kurimoto Junki , Takagi Hiroshi , Miyata Takashi , Kawaguchi Yohei , Hodai Yuichi , Tsumura Tetsuro , Hagiwara Daisuke , Kobayashi Tomoko , Yasuda Yoshinori , Sugiyama Mariko , Onoue Takeshi , Iwama Shintaro , Suga Hidetaka , Banno Ryoichi , Katsuki Takeshi , Ando Fumiaki , Uchida Shinichi , Arima Hiroshi 
Published: May 2022

Abstract

The symptoms of diabetes insipidus can be masked by the concurrence of adrenal insufficiency and emerge after the administration of hydrocortisone, occasionally at high doses. To elucidate the mechanism underlying polyuria induced by the administration of high-dose corticosteroids in deficiency of arginine vasopressin (AVP), we first examined the secretion of AVP in three patients in whom polyuria was observed only after the administration of high-dose corticosteroids. Next, we examined the effects of dexamethasone or aldosterone on water balance in wild-type and familial neurohypophysial diabetes insipidus (FNDI) model mice. The hypertonic saline test showed that AVP secretion was partially impaired in all patients. In one patient, there were no apparent changes in AVP secretion before and after the administration of high-dose corticosteroids. In FNDI mice, unlike dexamethasone, the administration of aldosterone increased urine volumes and decreased urine osmolality. The immunohistochemical analyses showed that, after the administration of aldosterone in FNDI mice, aquaporin-2expression was decreased in the apical membrane and increased in the basolateral membrane in the collecting duct. These changes were not observed in wild-type mice. The present data suggest that treatment with mineralocorticoids induces polyuria by reducing aquaporin-2 expression in the apical membrane of the kidney in partial AVP deficiency.
Vitamin insufficiency after surgery for oesophagogastric neoplasms: a prospective intervention study VITAMin Insufficiency in oesophagogastric Neoplasms or the VITAMIN study
Authors: Velden Ariadne L. , Vermeer Thomas A. , Boerma Evert-Jan G. , Belgers Eric H.J. , Stoot Jan H.M.B. , Leers Mathie P.G. , Sosef Meindert N. , Vijgen Guy H.E.J. 
Published: May 2022

Abstract
Background: Oesophageal cancer (EC) and gastric cancer (GC) are among the top ten cancers worldwide. Both diseases have impact on the nutritional status of patients and their quality of life (QoL). Preoperative malnutrition is reported in 42-80%. However, studies investigating postoperative nutritional status are limited and postoperative identification and treatment of micro- and macro-nutritional deficiencies are currently lacking in (inter-)national guidelines. The aim of this study is to identify and target micronutrient deficiencies after surgery for oesophageal or gastric neoplasms.Methods: This is a single-centre prospective intervention trial performed in Zuyderland Medical Centre. A total of 248 patients who underwent oesophagectomy (n=124) or (sub)total gastrectomy (n=124) from 2011 until 2022 will be included (Cohens’d 0.4, power 80%, two-sided α 0.05, 20% dropout). Both groups will receive Calcium Soft Chew D3 and a tailormade multivitamin supplement (MVS); the oesophagectomy group will receive Multi-E and the gastrectomy group will receive Multi-G. The MVSs will be taken once daily and Calcium Soft Chew D3 twice daily. Supplementation will start after baseline measurements. At baseline (T=0), blood withdrawal for micronutrient analysis and faecal elastase-1 analysis for exocrine pancreas insufficiency (EPI) will be performed. Additionally, patients will receive questionnaires regarding QoL and dietary behaviour. After 180 days of supplementation (T=1), baseline measurements will be repeated, and the supplement tolerance questionnaire will be completed. Measurements will also be conducted after 360 days (T=2) and after 720 days (T=3) of supplementation. The main study parameter is micronutrient deficiency (yes/no) for all measurements. Secondary parameters include occurrence of EPI (n, %), occurrence of diarrhoea (n, %), steatorrhea (n, %) or bloating (n, %), time between surgery and start of supplementation (mean in months), QoL (questionnaires) at all time points. We hypothesize that vitamin B12, folic acid, vitamin D and ferritin are the most common deficiencies, and supplementation may resolve measured deficiencies. Discussion: If micronutrient deficiencies are present in this population and daily supplementation resolves these deficiencies, routine monitoring and supplementation of micronutrient deficiencies can be implemented in the standard postoperative care of oesophageal and gastric surgery.Trial registration: registered as NL9787 in the Netherlands Trial Registration, registered on October 18th, 2021 on https://www.trialregister.nl/trial/9787
Stepping on invisible land: on the importance to communicate the value of soils
Authors: Latawiec Agnieszka Ewa , Markowicz Magdalena E. , Medeiros Bruna , Mendes Maiara S. , Rodrigues Aline F. , Gomes Fernanda , Valle Breno D. , Lisowska Katarzyna , Drosik Adam , Capeche Claudio , Maioli Veronica , Fedorowicz Karolina , Azevedo Luciana 
Published: May 2022

Abstract
Soils play fundamental roles in the functioning of the Earth's ecosystems. Despite numerous initiatives to protect soils, it continues to be generally perceived as dirt or, at best, the surface we walk on. To better understand soil perception by the public, we conducted a survey with 99 participants from Poland and Brazil. We applied an opportunity sampling and conducted semi-structured interviews with 40 respondents from Poland and 30 from Brazil, and 29 unstructured interviews in Brazil. Most of the respondents (53%) of the semi-structured interviews associated soil with the surface where plants grow while 27% said that it is the ground we step on. When asked about pro-environmental campaigns, none of the respondents pointed to soil-related initiative. Most of the respondents (99%) claimed that there is a need to increase the knowledge about the importance of soils, mostly through education (30%). The majority of the respondents of the unstructured interviews in Brazil indicated provision services provided by soils and pointed to the need for youth engagement on soil communication, corroborating the results from the semi-structured interviews. To address this, present the results on artistic workshops as an experimental model for teaching and dissemination. We present two short documentary movies presenting the results from unstructured interviews and the artistic workshops which can be used as data gathering tool, teaching tool and for dissemination purposes. This paper not only presents primary data on the crucial problem of soil recognition but also presents a range of transdisciplinary approaches to help problem solving.
Comparison of dynamic and static spacers for the treatment of infections following total knee replacement：a systematic review and meta-analysis
Authors: Tao Jiasheng , Yan Zijian , Pu Bin , Chen Ming , Hu Xiaorong , Dong Hang 
Published: May 2022

Abstract
Background
Revision surgery is the most common treatment for patients who develop infection after total knee arthroplasty. Two types of spacers are often used in revision surgery: dynamic spacers and static spacers. The comparative efficacy of these two types of spacers on knee prosthesis infections is not well established. Therefore, we carried out a systematic evaluation and meta-analysis with the aim of comparing the difference in efficacy between dynamic and static spacers.
Methods
We conducted the literature search in PubMed, Web of Science, Cochrane Library, and Embase databases. The articles searched were clinical study comparing the difference in efficacy between dynamic spacers and static spacers for the treatment of prosthetic infections occurring after total knee arthroplasty.
Results
We conducted a literature search and screening based on the principles of PICOS. Ultimately, 14 relevant clinical studies were included in our current study. We use infection control rate as the primary evaluation indicator. The KSS knee scores (KSSs), KSS functional scores, bone loss and ROM are secondary indicators of evaluation. Thirteen of these included studies reported the infection control rates, with no significant difference between dynamic and static shims (RR: 1.03; 95% Cl: 0.98,1.09; P = 0.179 > 0.05). The KSSs were reported in 10 articles (RR: 5.98; 95% CI:0.52, 11.43; P = 0.032 < 0.05). 6 articles reported the KSS functional scores (RR: 13.90; 95% CI:4.95, 22.85; P = 0.02 < 0.05). 12 articles reported the ROM (RR: 17.23. 95% CI:10.18, 24.27; P < 0.0001).Six articles reported the bone loss (RR: 2.04; 95% CI:1.11, 3.77; P = 0.022 < 0.05).
Conclusion
Current evidence demonstrates that dynamic spacers are comparable to static spacers in controlling prosthetic joint infection. In terms of improving the functional prognosis of the knee joint, dynamic spacers are more effective than static spacers.
NETO2 promotes progression of prostate cancer by inhibiting the cellular senescence pathway
Authors: Liu Yangzhou , Xiang Qian , Ma Yuxiang , Wang Zuomin , Pan Jinyou , Wang Jiamin , Zhou Mingda , Lin Jingwei , Cai Yingxin , Zhao Zhigang 
Published: May 2022

Abstract
Purpose: Prostate cancer (PCa) has become the most frequently occurring cancer among western men, due to the rapid progression of tumor, late events will inevitably occur, which leads to poor prognosis of patients. Therefore, it is of great significance to explore the molecular mechanism of tumor progression.Methods: Herein, we conducted a transcriptomic analysis using public database to search for key genes that affect PCa progression. The correlation between gene expression and clinical pathological parameters and patient prognosis were examined, and it was verified in clinical samples. Next, we established cell lines by RNA interference, and studied its biological function by MTS, EdU, colony formation, wound-healing and transwell assay. The impact of gene on tumor growth was examined in nude mice xenograft model. Finally, high-throughput sequencing and signal pathway analysis were used to explore the molecular mechanism of gene action.Results: By combining clinical samples with public databases, we found that NETO2 expression was markedly elevated in tumors especially in metastatic tumors compared with normal tissues, and the expression level of NETO2 was closely associated with the clinical pathological parameters and prognosis of the patients. Functionally, NETO2 drove PCa cell proliferation, migration and invasion in vitro, and promoted growth of PCa cells in vivo. Moreover, through transcriptome high-throughput sequencing and experimental verification, our data demonstrate that NETO2 inhibits PCa cellular senescence via modulating p53-p21 pathway.Conclusions: Our results indicate that NETO2 plays an oncogenic role in PCa, which provides a new idea for clinical diagnosis and treatment of refractory PCa.
Reconstruction of sedimentation rates based on the chronological framework of Lake Pykara, Tamil Nadu, India.
Authors: Singh Krishna Kumar , Sivaprakasam  
Published: May 2022

Abstract
This work presents a piece of initial information about the estimation of the sedimentation rate for Lake Pykara. In this investigation, a chronological sequence of sediment core was set up dependent on 137Cs, and 210Pbex analysis to study sediment accumulation rates in Lake Pykara. Caesium-137 (Cs) is an artificial radionuclide and is regularly utilized in building up the chronology of lake sediments in the Anthropocene period. The unsupported 210Pb profile shows a non-exponential decline of 210Pb activity with sediment depth. Sedimentation rates dependent on global atmospheric nuclear weapons maximum fallout of 137Cs (1963) bolster the utilization of the consistent rate of 210Pb supply (CRS) model in core sediments. The geochronology studies of the core were performed using the 137Cs method, to evaluate the model of time changes in the sediment. The 137Cs radioactivity was resolved directly by gamma spectrometry and fluctuated from 13.11 ± 1.3 Bq kg-1 for top layers to 1.21 ± 0.1 Bq kg-1 for the bottom of the core. Two trademark peaks of 137Cs radioactivity identified with the global fallouts after atomic weapons testing and the Chernobyl mishap were observed and used to affirm the 210Pb dating method. Radioactivity of 210Pbex ranged from 8.00 ± 1.0 to 1.40 ± 0.1 Bq kg− 1. The mean sedimentation rate evaluated from both models was 0.71 ± 0.06 cm yr-1, while the estimated age of Lake Pykara was 514.08 years (137Cs), and 521.43 years (210Pbex) respectively.
Removal of Pollutants from Landfill Leachate by Adsorption with Nano Zero Valent Iron Particles (nZVI): Adsorption Isotherms and Kinetic Studies
Authors: Göçer Serdar , Zaimoğlu Zeynep , CIRK Kevser 
Published: May 2022

Abstract
Nano zero-valent iron (nZVI) is an effective adsorbent for removing various organic and inorganic contaminants. In this study, nZVI particles, synthesized in our previous work, were used for landfill leachate pre-treatment. The adsorption performance was tested at various adsorbent concentrations (50-500mg Fe0/L), pH (3–8), and contact times (15-330min). Chemical Oxygen Demand (COD), Dissolved Organic Carbon (DOC), Nitrate (NO3−) and Ammonium (NH4+) removal efficiency was approximately 75%, 60%, 57%, and 33%, respectively. The obtained data were fitted well by the Langmuir isotherm and adsorption kinetics of pseudo-second-order equations (R2 > 0.9). The adsorption capacities were found to be 29.62mg/g, 21.01mg/g, and 3.12mg/g, for DOC, NH4+, and NO3− respectively at Fe0 concentration of 50mg Fe0/L, pH of 8, and contact time of 120min which was determined as the effective operational conditions in this work. The obtained removal levels were higher compared to the conventional activated carbon adsorption (72.3%). Results suggest that nZVI has the potential to create effective adsorption relevant to landfill leachate pre-treatment thereby providing more efficient biological treatment by decreasing important pollutants before biological treatment.
Multi-timescale performances of groundwater drought in connection with climate
Authors: Zhu Ruirui , Zheng Hongxing , Jakeman Anthony J. , Chiew Francis H.S. 
Published: May 2022

Abstract
The Millennium drought occurred around 1997–2009 throughout southeastern Australia has led to recorded low groundwater levels causing considerable economical losses. Improving the drought resilience of at-risk groundwater systems has been recognized as a priority for sustainable water resources management in the region. This study introduces the standardized groundwater discharge index (SGDI) to assess groundwater drought performance at multiple timescales for catchments in the southeastern Murray-Darling Basin. The response time of groundwater drought to precipitation drought is found above 12 months according to the relationships between SGDI and the standardized precipitation index (SPI). The performance of groundwater drought, indicated by resilience and resistance, overall shows that catchments with higher drought resilience are often accompanied by lower drought resistance and vulnerability. Groundwater drought is found less resilient but more resistant than precipitation drought due to the buffer capacity of the groundwater system. The determinants of groundwater drought performance at different timescales are identified by a machine learning approach. The relationships between groundwater drought performance metrics and their determinants are found highly nonlinear and distinctly different among the timescales. Climate factors (mean annual precipitation and potential evapotranspiration) and catchment physical properties (relief, slope, water holding capacity, vegetation) can explain up to 60% of the spatial variance in drought resilience and resistance across the region at the 12-month scale. Our findings provide crucial insight into the groundwater drought management and open potential pathways for improving groundwater drought resilience and resistance to mitigate the drought impacts potentially driven by the changing climate.
A kinetic, isotherm adsorption, and thermodynamic study of Congo red coagulation using Leucaena crude extract as natural coagulant
Authors: Kristianto Hans , Manurung Natasa , Wardhani Irene Kusuma , Prasetyo Susiana , Sugih Asaf K. , Arbita Ariestya A. 
Published: May 2022

Abstract
The utilization of various natural resources as coagulant to treat various types of water and wastewater has seen considerable growth in recent years. The coagulation mechanism of natural coagulant is commonly charge neutralization followed by adsorption during the floc growth. However, due to lack of information, further investigation into the nature of the coagulation mechanism is needed. In this study, the coagulation of Congo red synthetic wastewater using crude leucaena extract was investigated at various initial Congo red concentrations (50–100 mg/L) and coagulation temperatures ranging from 30 to 50 °C. Furthermore, the nature of coagulation was investigated using various adsorption isotherms (the Langmuir, Freundlich, Temkin, and Brunauer-Emmet-Teller models) and kinetic models (pseudo-first, pseudo-second, Elovich, and intraparticle models). It was found that the Congo red concentrations, coagulation temperatures, and their interaction are significant to the dye removal. The sedimentation was well described by the pseudo-second order kinetic model, and the coagulation process followed the Langmuir isotherm. This indicates that the coagulation process involved chemisorption with monolayer formation on the coagulant. Moreover, the thermodynamic study shows that the coagulation was both endothermic and spontaneous.
Satisfaction With Health Care Services at the Pediatric Specialist Clinic of the National Referral Center in Malaysia: Cross-sectional Study of Caregivers’ Perspectives
Authors: M Selvarajah Thinakaran , Yamamoto Eiko , Saw Yu Mon , Kariya Tetsuyoshi , Hamajima Nobuyuki 
Published: May 2022

Background
The concept of customer satisfaction is gaining hold in all corporate sectors worldwide, and a satisfaction survey is used as a tool to discover service problems and as a chance for customers to rate their experience with health care services. A high degree of patient satisfaction with the services given has been found in numerous studies conducted in Malaysian public health care facilities. However, there is limited information available on caregiver satisfaction with pediatric clinics run by the Ministry of Health (MoH) of Malaysia.

Objective
This was the first research performed at a public hospital’s pediatric clinic, which was the first hospital to adopt the public-private-partnership model under the MoH, with the aim of discovering the prevalence and factors affecting the satisfaction of caregivers at the national referral center.

Methods
Cross-sectional research using the standard self-administered SERVQUAL questionnaire was conducted among caregivers accompanying their children to the clinic. The questionnaire consists of 16 paired statements to evaluate their expectations and experiences with the clinic services.

Results
A total of 459 caregivers were involved in this study with a majority aged between 30 and 39 years (n=254, 55.4%). Caregivers from the Indian community (adjusted odds ratio [AOR] 2.91, 95% CI 1.37-6.18) and lower income groups (AOR 2.94, 95% CI 1.87-4.64), and those with lower educational backgrounds (AOR 3.58, 95% CI 1.19-10.72) were more likely to be satisfied with the quality of pediatric clinic services. Housewives/househusbands (AOR 0.48, 95% CI 0.25-0.90), on the other hand, appeared less likely to be satisfied with the services provided during their visit to the clinic. Looking at overall patient satisfaction, 50.5% (n=232) of caregivers demonstrated satisfaction with the quality of services, compared to 49.5% (n=227) of dissatisfied respondents.

Conclusions
This paper suggests that, although most caregivers are satisfied with the services, greater emphasis must be placed on delivering reliable service in response to the MoH’s mission to provide quality and integrated people-centered health services in Malaysia.