bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluating the cost‐effectiveness of hepatitis B vaccination strategies in high‐impact settings for adults
Authors: Hall Eric W. , Gounder Prabhu , Angles John , Nelson Noele P. , Rosenberg Eli S. , Weng Mark K. 
Published: October 2022

AbstractAdults at increased risk for hepatitis B virus (HBV) infection are recommended to receive vaccination. We conducted a cost utility analysis to evaluate approaches for implementing that recommendation in selected high‐risk settings: community outreach events with a large proportion of immigrants, syringe service programs, substance use treatment centres, sexually transmitted infection (STI) clinics, tuberculosis (TB) clinics and jails. We utilized a decision tree framework with a Markov disease progression model to compare quality adjusted life‐years and cost in 2021 United States dollars from four strategies: a 3‐dose vaccination regimen with prevaccination screening and testing (PVST; baseline comparison); PVST at the initial encounter followed by a 2‐dose series (Intervention 1); PVST with the first dose of a 2‐dose vaccination series at the initial encounter (Intervention 2); and a 2‐dose vaccination series without PVST (Intervention 3). In all settings, Intervention 1 resulted in worse health outcomes compared with the baseline strategy. Intervention 2 averted incident chronic HBV infections in all settings (range −9.4% in TB clinics, −14.8% in syringe service programs) and was a cost‐saving approach in settings with higher risk of infection (i.e. jails, −$266 per person; syringe service programs, −$597; substance use treatment centres, −$130). Providing a 2‐dose vaccination series without any screening (Intervention 3) averted incident HBV infections and was cost‐saving in all settings but resulted in more HBV‐related deaths in settings with higher HBV prevalence. These results demonstrate a 2‐dose vaccine series is a cost‐effective approach in these high‐impact settings, even if prevaccination testing is not possible.
Whole genome population structure of North Atlantic kelp confirms high‐latitude glacial refugia
Authors: Bringloe Trevor T. , Fort Antoine , Inaba Masami , Sulpice Ronan , Ghriofa Cliodhna Ní , Mols‐Mortensen Agnes , Filbee‐Dexter Karen , Vieira Christophe , Kawai Hiroshi , Hanyuda Takeaki , Krause‐Jensen Dorte , Olesen Birgit , Starko Samuel , Verbruggen Heroen 
Published: October 2022

AbstractCoastal refugia during the Last Glacial Maximum (~21,000 years ago) have been hypothesized at high latitudes in the North Atlantic, suggesting marine populations persisted through cycles of glaciation and are potentially adapted to local environments. Here, whole‐genome sequencing was used to test whether North Atlantic marine coastal populations of the kelp Alaria esculenta survived in the area of southwestern Greenland during the Last Glacial Maximum. We present the first annotated genome for A. esculenta and call variant positions in 54 individuals from populations in Atlantic Canada, Greenland, Faroe Islands, Norway and Ireland. Differentiation across populations was reflected in ~1.9 million single nucleotide polymorphisms, which further revealed mixed ancestry in the Faroe Islands individuals between putative Greenlandic and European lineages. Time‐calibrated organellar phylogenies suggested Greenlandic populations were established during the last interglacial period more than 100,000 years ago, and that the Faroe Islands population was probably established following the Last Glacial Maximum. Patterns in population statistics, including nucleotide diversity, minor allele frequencies, heterozygosity and linkage disequilibrium decay, nonetheless suggested glaciation reduced Canadian Atlantic and Greenlandic populations to small effective sizes during the most recent glaciation. Functional differentiation was further reflected in exon read coverage, which revealed expansions unique to Greenland in 337 exons representing 162 genes, and a modest degree of exon loss (103 exons from 56 genes). Altogether, our genomic results provide strong evidence that A. esculenta populations were resilient to past climatic fluctuations related to glaciations and that high‐latitude populations are potentially already adapted to local conditions as a result.
Enzyme 1 of the phosphoenolpyruvate:sugar phosphotransferase system is involved in resistance to MreB disruption in wild‐type and ∆envC cells
Authors: Sloan Ryan , Surber Jacob , Roy Emma J. , Hartig Ethan , Morgenstein Randy M. 
Published: October 2022

AbstractCell wall synthesis in bacteria is determined by two protein complexes: the elongasome and divisome. The elongasome is coordinated by the actin homolog MreB while the divisome is organized by the tubulin homolog FtsZ. While these two systems must coordinate with each other to ensure that elongation and division are coregulated, this cross talk has been understudied. Using the MreB depolymerizing agent, A22, we found that multiple gene deletions result in cells exhibiting increased sensitivity to MreB depolymerization. One of those genes encodes for EnvC, a part of the divisome that is responsible for splitting daughter cells after the completion of cytokinesis through the activation of specific amidases. Here we show this increased sensitivity to A22 works through two known amidase targets of EnvC: AmiA and AmiB. In addition, suppressor analysis revealed that mutations in enzyme 1 of the phosphoenolpyruvate:sugar phosphotransferase system (PTS) can suppress the effects of A22 in both wild‐type and envC deletion cells. Together this work helps to link elongation, division, and metabolism.
The Research–Practice Dialogue in Second Language Learning and Teaching: Past, Present, and Future
Authors: Sato Masatoshi , Loewen Shawn 
Published: October 2022

AbstractThis article explores ways in which a dialogue between researchers and practitioners can be bidirectional, effective, and beneficial for the two professional communities. We suggest concrete directions for second language (L2) research: (a) a collaborative mindset, (b) the nature of research, (c) venues for dialogue, and (d) institutional support. First, we argue that we, researchers and teachers alike, can develop a collaborative mindset and understand that the dialogue is established by equal contributions and benefits. Second, we discuss that if a researcher's intention is to impact practice, they need to consider the practice relevance of their studies. We propose practice‐based research, in which practitioners and researchers work together for development and implementation of research. Third, we explore venues where reciprocal contributions may be explored, including teacher‐training programs, professional development workshops, and university–school collaborations. Finally, we share our hopes that institutions (universities and schools) will provide support for researchers and practitioners that would help create and facilitate reciprocal relationships, such as time release and promotive incentives. Overall, we argue that researchers shoulder the lion's share of responsibility in paving a path for a productive research–practice dialogue in the future.
Biological abdominal wall expansion in pediatric liver recipients after transplantation with large‐for‐size organs
Authors: Goetz Markus , Jurczyk Maria , Grothues Dirk , Knoppke Birgit , Junger Henrik , Melter Michael , Schlitt Hans J. , Brunner Stefan M. , Brennfleck Frank W. 
Published: October 2022

AbstractBackgroundAfter pediatric split liver transplantation, intra‐abdominal loss of domain due to large‐for‐size left lateral grafts is a frequent problem for fascial closure and potentially leads to reduced liver perfusion and abdominal compartment syndrome. Therefore, delayed fascial closure with the use of temporary silastic meshes and reoperation or alternative fascial bridging procedures are necessary.MethodsBetween March 2019 and October 2021, biologic meshes were used for abdominal wall expansion in 6 cases of pediatric split liver transplantation. These cases were analyzed retrospectively.ResultsOne male and 5 female children with median age of 6 months (range: 0–57 months) and weight of 6 kg (range: 3.5–22 kg) received a large‐for‐size left lateral graft. Graft‐to‐recipient weight ratio (GRWR) was 4.8% (range: 1.5%–8.5%) in median. Biologic mesh implantation for abdominal wall expansion was done in median 7 days (range: 3–11 days) after transplantation when signs of abdominal compartment syndrome with portal vein thrombosis in 3 and of the liver artery in 1 case occurred. In 2 cases, bovine acellular collagen matrix and 4 cases ovine reinforced tissue matrix was used. Median follow‐up was 12.5 months (range: 4–28 months) and showed good liver perfusion by sonography and normal corporal development without signs of ventral hernia. One patient died because of fulminant graft rejection and emergency re‐transplantation 11 months after the initial transplantation.ConclusionsBiologic meshes can be used as safe method for abdominal wall expansion to achieve fascial closure in large‐for‐size liver transplant recipients. Usage for primary fascial closure can be considered in selected patients.
Mixed‐model assembly lines with variable takt and open stations
Authors: Huchzermeier Arnd , Mönch Tobias 
Published: October 2022

Industry trends such as product customization, radical innovation, and local production accelerate the adoption of mixed‐model assembly lines (MMALs) that can cope with a widening gap between model processing times and true build to order capabilitiy. The existing high work content deviations on such assembly lines stress production planning, especially the assembly line sequencing. Most manufacturers set the launching rate for all assembly line products to a fixed launching rate resulting in rising utility work and idle time when system load increases. We present an “ideal” variable rate launching (VRL) case resulting in minimal computation and achieving 100% productivity (full elimination of idle time and utility work) for balanced assembly times and homogeneous station lengths. Managers should foster the ideal circumstances where operators need not wait for a preceding task to be completed and product sequence restrictions are eliminated, thus enabling unmatched production flexibility. Furthermore, we present a mixed‐integer model to analyze both closed and open workstations on an MMAL for fixed rate launching and VRL. This model incorporates costs not only for labor inefficiencies but also for extending the line length. We present a heuristic solution method when process times and station lengths are heterogeneous and demonstrate that the variable takt dominates the fixed takt. In a numerical, industrial benchmark study, we illustrate that a VRL strategy with open stations has significantly lower labor costs as well as a substantially reduced total line length and thus lower throughput time.
Anarchism/anachronism: Mobilising archiveology against an urban chronopolitics of dispossession
Authors: Collins Erin 
Published: October 2022

AbstractWhile moments of historic rupture do usher in radically new conditions for claiming urban space and power, the eras they cleave do not align neatly in the lives of the urban precariat. Rather, they overspill and interdigitate, saturating the present. This paper vivifies heterotemporality as an analytic, rather than descriptive, category for urban politics and scholarship. Drawing together Walter Benjamin's radical mode of historical and image‐centric inquiry with Mimi Nguyen's and Dai Jinhua's critiques of recombinant imperial formations, I seek to unsettle the uncritical chronopolitics of rupture that has practically and discursively undergirded dispossession in Phnom Penh, Cambodia. Arguing against strategic representations of urban rupture as only a break from the past, I offer instead a dialectical conception of rupture as interacting movements of break and amplification of the past in the present. Advancing ‘archiveology’ as an urban research praxis that activates a heterotemporal, collective urban archive – composed of the built landscape, oral accounts, historical records and filmic representations – shocks the potential of what has been, constellating alternative politics of the present. I suggest that this theoretical‐methodological framework offers critical insights beyond Phnom Penh, especially for other historic‐geographies that have been strategically attenuated via categorical post‐s (e.g., post‐colonial, post‐socialist, post‐conflict).
Tick‐borne encephalitis epidemic in Hungary 1951–2021: The story and lessons learned
Authors: Egyed László , Nagy Anna , Lakos András , Zöldi Viktor , Lang Zsolt 
Published: October 2022

AbstractThe authors analysed epidemiological data of the Hungarian tick‐borne encephalitis epidemic from the past seven decades. A total of 911 meningitis serosa cases were described from 1930‐1950 s by local hospital physicians, indicating that the virus had been present in the country decades before its official identification in 1952. The virus spread freely in the 1950s–1960s, occupying almost all habitats where ticks occurred in large numbers. The increasing number of cases drove authorities to classify this illness as a notifiable disease in 1977 and to organize the first measures to stop the epidemic. Statistical analysis revealed that the large‐scale vaccination launched from the 1990s was responsible for the sharp decrease in the number of human cases from 1997. A significant negative correlation was found between the number of vaccine doses sold and human cases 6 years later. The TBEV endemic area covers 16.57% of the territory and 16.65% of the population of the country. In the last 10 years, 186,000 vaccine doses/year in average were enough to keep the incidence of human TBEV infections between 0.45 and 0.06/100,000 persons. A 20‐year‐long study found evidence for easing clinical signs in TBEV‐infected hospitalized patients. Statistics found a sharp decrease in the number of samples sent for TBEV diagnosis after 1989. Male dominance of patients was characteristic of the epidemics since the 1940s, but now analysis of detailed data from the 1981–2021 period (60.5%–87.5%) proved the statistical significance of this dominance. Obviously, the voluntary vaccination programme was the tool which broke the spread of the epidemic. Widespread public awareness of the disease and the tick vector, probable evolutionary spread of less pathogenic virus strains supplemented with the vaccination campaign led to a negligible level of human TBE cases in Hungary in the last years.
Adaptive Process Planning for Additive/Subtractive Hybrid Manufacturing of Overhang Features
Authors: Bai Qian , Gao Yingming , Qiao Guowen , Kang Renke , Zhang Yingwei 
Published: October 2022

Abstract
Additive/subtractive hybrid manufacturing (ASHM) combines the selective laser melting (SLM) with precision milling for a better surface finish as well as geometric and dimensional accuracies of a part. In the SLM-based ASHM, the inherent characteristic of the powder bed determines that the AM and milling process are both three-axis. To produce a complex part with overhang features, alternations between SLM and milling are needed. The alternating sequence is of significance in the overall process: a large slab height of continuous SLM may cause tool/part collision; while a small slab height could reduce the fabrication efficiency. In addition, the remelting of the material during SLM causes the distortion of substantial machined surface, and thus deteriorates the surface finish of a part. However, there have little published reports on process planning for three-axis SLM-based ASHM with the consideration of alternation planning and surface finish improvement. This paper proposed a new adaptive process planning method, in which maximum slab heights of continuous SLM were calculated adaptively, and the shielding height was also employed to protect the machined surface. The overhang angles at different locations of a typical complex part were calculated by a triangular facet method. A collision detection method to justify the interference of the tool and as-built part was proposed, and the maximum slab heights were then determined. ASHM experiment was conducted to fabricate small samples with different overhang angles, and the shielding height was determined based on the surface quality. A propeller with overhang features was manufactured using this new planning method. The result shows that the proposed method improved the fabrication efficiency, reduced the number of process alternations as well as improved the surface finish.
Hierarchical Porous Structure Fabrication Via Hybrid Stereolithography and Inkjet Printing With Sacrificial Liquid
Authors: Yoon Yeowon , Xu Yang , Chen Yong 
Published: October 2022

Abstract
Inspired by porous morphology in nature, such as bone and lung tissues, synthetic porous materials are widely adopted in engineering applications that require lightweight, thermal resistance, energy absorption, and structural flexibility. One of the main challenges in the current porous material manufacturing techniques is their limited control over individual pore size, connectivity, and distribution. This paper presents a novel additive manufacturing process to fabricate porosity-embedded structures by integrating stereolithography and inkjet printing using a sacrificial liquid–water. A solenoid-based inkjet nozzle dispenses water droplets onto a layer of liquid photopolymer resin. Then the resin layer is photocured by a mask image projection device using a digital light processing device. The photocuring process defines the layer profile and captures the deposited water droplets in the solidified layer. The refilled fresh resin will further embed water droplets and form a new layer for the subsequent water droplet deposition. Three-dimensional (3D) structures with embedded water droplets can be printed layer-by-layer. The captured water will evaporate when heated, leaving an air-filled porous 3D structure. By selectively depositing water droplets and varying inkjet printing parameters, including pressure, nozzle opening time, and jetting frequency, the micropores whose sizes from 100 µm to 500 µm and distributions within the 3D-printed part can be modulated. This hybrid process can fabricate 3D structures with homogenously distributed pores and graded polymer structures with varying porosities. The elastic modulus of 3D-printed foam structures in different pore distributions has been tested and compared.
GAN-DUF: Hierarchical Deep Generative Models for Design Under Free-Form Geometric Uncertainty
Authors: Chen Wei (Wayne) , Lee Doksoo , Balogun Oluwaseyi , Chen Wei 
Published: October 2022

Abstract
Deep generative models have demonstrated effectiveness in learning compact and expressive design representations that significantly improve geometric design optimization. However, these models do not consider the uncertainty introduced by manufacturing or fabrication. The past work that quantifies such uncertainty often makes simplifying assumptions on geometric variations, while the “real-world,” “free-form” uncertainty and its impact on design performance are difficult to quantify due to the high dimensionality. To address this issue, we propose a generative adversarial network-based design under uncertainty framework (GAN-DUF), which contains a deep generative model that simultaneously learns a compact representation of nominal (ideal) designs and the conditional distribution of fabricated designs given any nominal design. This opens up new possibilities of (1) building a universal uncertainty quantification model compatible with both shape and topological designs, (2) modeling free-form geometric uncertainties without the need to make any assumptions on the distribution of geometric variability, and (3) allowing fast prediction of uncertainties for new nominal designs. We can combine the proposed deep generative model with robust design optimization or reliability-based design optimization for design under uncertainty. We demonstrated the framework on two real-world engineering design examples and showed its capability of finding the solution that possesses better performance after fabrication.
Optimization-Based Disassembly Sequence Planning Under Uncertainty for Human–Robot Collaboration
Authors: Liao Hao-yu , Chen Yuhao , Hu Boyi , Behdad Sara 
Published: October 2022

Abstract
Disassembly is an essential step for remanufacturing end-of-life (EOL) products. Optimization of disassembly sequences and the utilization of robotic technology could alleviate the labor-intensive nature of dismantling operations. This study proposes an optimization framework for disassembly sequence planning under uncertainty considering human–robot collaboration. The proposed framework combines three attributes: disassembly cost, safety, and complexity of disassembly, namely disassembleability, to identify the optimal disassembly path and allocate operations between human and robot. A multi-attribute utility function is used to address uncertainty and make a tradeoff among multiple attributes. The disassembly time reflects the cost of disassembly which is assumed to be an uncertain parameter with a Beta distribution; the disassembleability evaluates the feasibility of conducting operations by robot; finally, the safety index ensures the protection of human workers in the work environment. An example of dismantling a desktop computer is used to show the application. The model identifies the optimal disassembly sequence with less disassembly cost, high disassembleability, and increased safety index while allocating disassembly operations among human and robot. A sensitivity analysis is conducted to show the model's performance when changing the disassembly cost for the robot.
Supplemental Material: Stratigraphy of the Eocene–Oligocene Titus Canyon Formation, Death Valley, California, and Eocene extensional tectonism in the Basin and Range
Authors: Midttun N. , al. et 
Published: October 2022

<p>Table S1: Analytical data for Titus Canyon detrital zircon U-Pb analyses. Table S2: Analytical data for Titus Canyon zircon (U-Th)/He analyses. Table S3: Analytical data for <sup>40</sup>Ar/<sup>39</sup>Ar ages of Gutenkunst (2006). </p>