bluuebunny/crossref_metadata_2025_split huggingface dataset:
European collaboration on health technology assessment: looking backward and forward
Authors: Ruether Alric , Imaz-Iglesia Iñaki , Bélorgey Chantal , Lo Scalzo Alessandra , Garrett Zoe , Guardian Marcus 
Published: April 2022

Abstract
The establishment of health technology assessment (HTA) has been an important topic in Europe for many years. There have been a series of activities starting with first projects in 1994 leading to joint actions from the European Network of HTA (EUnetHTA) ending in 2021. This long interval of engagement with HTA structures, methodology, and processes by all member states led to a reliable basis for European collaboration in HTA. This article shows milestones and developments from EUR-ASSESS in 1994 through the progress of EUnetHTA and the accompanying EU-HTA-Network up to the recent elaboration of the EU-HTA-Regulation. With the EU-HTA-Regulation HTA collaboration is taken out of the trial phase of more than 15 years. Through the previous EU HTA collaboration, the appreciation and understanding of the differences and complexities behind the HTA processes in the EU healthcare systems have improved. It is now necessary to make the final steps toward a sustainable European Network for HTA.
Mental disorder symptoms during the COVID-19 pandemic in Latin America – a systematic review and meta-analysis
Authors: Zhang Stephen X. , Batra Kavita , Xu Wen , Liu Tao , Dong Rebecca Kechen , Yin Allen , Delios Andrew Yilong , Chen Bryan Z. , Chen Richard Z. , Miller Saylor , Wan Xue , Ye Wenping , Chen Jiyao 
Published: April 2022

AbstractAimsThere is a lack of evidence related to the prevalence of mental health symptoms as well as their heterogeneities during the coronavirus disease 2019 (COVID-19) pandemic in Latin America, a large area spanning the equator. The current study aims to provide meta-analytical evidence on mental health symptoms during COVID-19 among frontline healthcare workers, general healthcare workers, the general population and university students in Latin America.MethodsBibliographical databases, such asPubMed, Embase, Web of Science, PsycINFOandmedRxiv, were systematically searched to identify pertinent studies up to August 13, 2021. Two coders performed the screening using predefined eligibility criteria. Studies were assigned quality scores using the Mixed Methods Appraisal Tool. The double data extraction method was used to minimise data entry errors.ResultsA total of 62 studies with 196 950 participants in Latin America were identified. The pooled prevalence of anxiety, depression, distress and insomnia was 35%, 35%, 32% and 35%, respectively. There was a higher prevalence of mental health symptoms in South America compared to Central America (36%v. 28%,p< 0.001), in countries speaking Portuguese (40%)v.Spanish (30%). The pooled prevalence of mental health symptoms in the general population, general healthcare workers, frontline healthcare workers and students in Latin America was 37%, 34%, 33% and 45%, respectively.ConclusionsThe high yet heterogenous level of prevalence of mental health symptoms emphasises the need for appropriate identification of psychological interventions in Latin America.
Late Quaternary Slip Rate of the Zihong Shan Branch and Its Implications for Strain Partitioning Along the Haiyuan Fault, Northeastern Tibetan Plateau
Authors: Yao Wenqian , Liu‐Zeng Jing , Klinger Yann , Wang Zijun , Shao Yanxiu , Han Longfei , Wang Wei , Zhang Jinyu , Liu Zhijun 
Published: April 2022

AbstractGeometrical complexities such as bends and branches are ubiquitous along strike‐slip faults. Understanding strain partitioning between the different fault strands along such sections is key to assessing kinematics and evolution through time of a fault system and related seismic hazards. The Haiyuan fault, one of the longest strike‐slip faults of the Tibetan Plateau, has developed a multi‐stranded complex fault geometry along the Hasi Shan restraining bend. In this study, we quantified the slip rate of the ∼50‐km‐long Zihong Shan fault, which is the poorly‐known southernmost fault strand of the Hasi Shan restraining bend. We computed high‐resolution DEMs and orthophotos to document the offset landforms along this fault using drone surveys. At selected sites with well‐preserved offset geomorphic markers, we quantified displaced terraces and channels using microtopography analysis. We dated the abandonment age of these terraces using 10Be cosmogenic depth profiles and OSL dating techniques. It yields a left‐lateral slip rate of 1.9 ± 0.6 mm/yr since ∼13 ka, which is similar to the rate of the main Hasi Shan branch that ruptured during the 1920 Haiyuan earthquake. The minimum total horizontal slip rate system summed over the multiple strands of the Haiyuan fault at the Hasi Shan restraining bend is 4.1 ± 0.6 mm/yr, without considering the vertical deformation rate of these fault strands. The rate is thus slightly smaller than, but comparable to, slip‐rates determined along the rest of the Haiyuan fault, east and west of the Hasi Shan restraining bend.
Three‐Dimensional Thermal Structure of East Asian Continental Lithosphere
Authors: Sun Yujun , Dong Shuwen , Wang Xueqiu , Liu Mian , Zhang Huai , Shi Yaolin 
Published: April 2022

AbstractThe thermal structure of East Asian continental lithosphere is critical for understanding its diffuse and variable intracontinental deformation in the Cenozoic. Here, we present a three‐dimensional model of the lithospheric thermal structure of East Asia, using the latest thermal conductivity and radiogenic heat production measurements in mainland China. The results show great lateral heterogeneity of lithospheric temperature. The crust of orogenic belts such as the Tibetan Plateau, the Mongolia Plateau, the Tian Shan orogen, and Northeast China, is generally characterized by high temperatures. Other regions of high crustal temperatures include the southeast coast of China and Lake Baikal. The heat sources for the crust also vary. In the Tibetan Plateau, high crustal temperatures result mainly from radiogenic heat production within the thick crust, indicating the influence of continental collision. However, high heat flow from the upper mantle is the main cause of high surface heat flow in the eastern part of East Asia, where the relatively thin lithosphere and hot asthenosphere is related to the subduction of the Pacific Plate. This subduction is also responsible for Cenozoic continental volcanoes in East Asia.
Saccharibacteria harness light energy using type-1 rhodopsins that may rely on retinal sourced from microbial hosts
Authors: Jaffe Alexander L , Konno Masae , Kawasaki Yuma , Kataoka Chihiro , Béjà Oded , Kandori Hideki , Inoue Keiichi , Banfield Jillian F 
Published: April 2022

Abstract
Microbial rhodopsins are a family of photoreceptive membrane proteins with a wide distribution across the Tree of Life. Within the candidate phyla radiation (CPR), a diverse group of putatively episymbiotic bacteria, the genetic potential to produce rhodopsins appears to be confined to a small clade of organisms from sunlit environments. Here, we characterize the metabolic context and biophysical features of Saccharibacteria Type-1 rhodopsin sequences derived from metagenomic surveys and show that these proteins function as outward proton pumps. This provides one of the only known mechanisms by which CPR can generate a proton gradient for ATP synthesis. These Saccharibacteria do not encode the genetic machinery to produce all-trans-retinal, the chromophore essential for rhodopsin function, but their rhodopsins are able to rapidly uptake this cofactor when provided in experimental assays. We found consistent evidence for the capacity to produce retinal from β-carotene in microorganisms co-occurring with Saccharibacteria, and this genetic potential was dominated by members of the Actinobacteria, which are known hosts of Saccharibacteria in other habitats. If Actinobacteria serve as hosts for Saccharibacteria in freshwater environments, exchange of retinal for use by rhodopsin may be a feature of their associations.
A simple score to predict early severe infections in patients with newly diagnosed multiple myeloma
Authors: Encinas Cristina , Hernandez-Rivas José-Ángel , Oriol Albert , Rosiñol Laura , Blanchard María-Jesús , Bellón José-María , García-Sanz Ramón , de la Rubia Javier , de la Guía Ana López , Jímenez-Ubieto Ana , Jarque Isidro , Iñigo Belén , Dourdil Victoria , de Arriba Felipe , Pérez-Ávila Clara Cuéllar , Gonzalez Yolanda , Hernández Miguel-Teodoro , Bargay Joan , Granell Miguel , Rodríguez-Otero Paula , Silvent Maialen , Cabrera Carmen , Rios Rafael , Alegre Adrián , Gironella Mercedes , Gonzalez Marta-Sonia , Sureda Anna , Sampol Antonia , Ocio Enrique M. , Krsnik Isabel , García Antonio , García-Mateo Aránzazu , Soler Joan-Alfons , Martín Jesús , Arguiñano José-María , Mateos María-Victoria , Bladé Joan , San-Miguel Jesús F. , Lahuerta Juan-José , Martínez-López Joaquín ,   GEM/PETHEMA (Grupo Español de Mieloma/Programa para el Estudio de la Terapéutica en Hemopatías Malignas) cooperative study group
Published: April 2022

AbstractInfections remain a common complication in patients with multiple myeloma (MM) and are associated with morbidity and mortality. A risk score to predict the probability of early severe infection could help to identify the patients that would benefit from preventive measures. We undertook a post hoc analysis of infections in four clinical trials from the Spanish Myeloma Group, involving a total of 1347 patients (847 transplant candidates). Regarding the GEM2010 > 65 trial, antibiotic prophylaxis was mandatory, so we excluded it from the final analysis. The incidence of severe infection episodes within the first 6 months was 13.8%, and majority of the patients experiencing the first episode before 4 months (11.1%). 1.2% of patients died because of infections within the first 6 months (1% before 4 months). Variables associated with increased risk of severe infection in the first 4 months included serum albumin ≤30 g/L, ECOG > 1, male sex, and non-IgA type MM. A simple risk score with these variables facilitated the identification of three risk groups with different probabilities of severe infection within the first 4 months: low-risk (score 0–2) 8.2%; intermediate-risk (score 3) 19.2%; and high-risk (score 4) 28.3%. Patients with intermediate/high risk could be candidates for prophylactic antibiotic therapies.
Exploring racial disparities in treatment patterns and outcomes for patients with multiple myeloma using real world data
Authors: Maignan Kathleen , Fashoyin-Aje Lola A. , Torres Aracelis Z. , Fernandes Laura L. , Gwise Thomas , Baxi Shrujal B. , Roose James P. , Rivera Donna R. , Shen Yuan Li , Kluetz Paul G. , Gormley Nicole J. 
Published: April 2022

AbstractThis retrospective observational study evaluated racial disparities among Black and White patients with multiple myeloma (MM). We included patients from a longitudinal de-identified EHR-derived database who had ≥2 visits recorded on or after 1/1/2011, documented treatment, and race listed as White or Black. Black patients (n = 1172) were more likely female (54.8%/42.9%) and younger (<65 years, 40.8%/30.8%) than White patients (n = 4637). Unadjusted median real-world overall survival (rwOS) indexed to first-line of therapy (LOT) was 64.6 months (95% CI: 57.8–74.0) for Blacks and 54.5 months (95% CI: 50.9–56.2) for Whites. Adjusted rwOS estimates (for sex, age at index date, and practice type) to either first- (aHR = 0.94; 95% CI: 0.84–1.06) or second-LOT (aHR = 0.90; 95% CI: 0.77–1.05) were similar. Unadjusted derived response rate (dRR) during first-LOT was 84.8% (95% CI: 80.7–88.1) for Blacks and 86.9% (95% CI: 85.0–88.5) for Whites (odds ratio [OR] = 0.78 [95% CI: 0.57–1.10]); in second-LOT, 67.2% (95% CI: 58.4–75.0) for Blacks and 72.4% (95% CI: 68.1–76.3) for Whites (OR = 0.72 [95% CI: 0.46–1.13]). High representation of Black patients enabled this robust analysis, albeit with limitations inherent to the observational data source, the retrospective design, and the analytic use of newly derived endpoints requiring further validation.
Brain radiotherapy, tremelimumab-mediated CTLA-4-directed blockade +/− trastuzumab in patients with breast cancer brain metastases
Authors: Page David B. , Beal Kathryn , Linch Stefanie N. , Spinelli Kateri J. , Rodine Micaela , Halpenny Darragh , Modi Shanu , Patil Sujata , Young Robert J. , Kaley Thomas , Merghoub Taha , Redmond David , Wong Phillip , Barker Christopher A. , Diab Adi , Norton Larry , McArthur Heather L. 
Published: April 2022

AbstractBreast cancer brain metastases (BCBM) are a common and devastating complication of metastatic breast cancer with conventional systemic therapies demonstrating limited effectiveness. Consequently, radiotherapy (RT) ± surgery remains the cornerstone of BCBM management. Because preclinical and clinical evidence indicate that immune checkpoint blockade (ICB) may synergize with RT to promote systemic tumor regression, we explored the safety and efficacy of RT and concurrent tremelimumab-mediated cytotoxic T-lymphocyte associated protein 4 (CTLA-4) ICB with tremelimumab ± HER2-directed therapy with trastuzumab for BCBM. Eligible patients had BCBM indicated for brain RT. A Simon two-stage design was adopted to evaluate the efficacy of tremelimumab and RT in 20 patients with human epidermal growth factor receptor normal (HER2−) BCBM. The safety of concurrent RT, tremelimumab, and trastuzumab was evaluated in a cohort of 6 HER2+ patients. The primary endpoint was 12-week non-central nervous system (CNS) disease control rate (DCR). Secondary endpoints included safety, survival, and CNS response. Exploratory correlatives included characterization of peripheral blood immune responses among exceptional responders. Tremelimumab plus RT ± trastuzumab was tolerated with no treatment-related grade 4 adverse events reported. The 12-week non-CNS DCR was 10% (2/20) in the HER2− cohort and 33% (2/6) in the HER2+ cohort. One patient with HER2+ disease experienced a durable partial response with evidence of peripheral T-cell activation. Thus, tremelimumab and RT ± trastuzumab was tolerated. Although modest clinical activity was observed in the HER2- efficacy cohort, encouraging responses were observed in the HER2+ safety cohort. Consequently, a trial to determine efficacy in HER2+ BCBM is planned.Clinical Trial Registration Number: NCT02563925.
Corrosion-induced hydrogen evolution, absorption, and cracking behaviors of ultra-high-strength galvanized and galvannealed steel sheets
Authors: Kim Sung Jin , Park Jin Sung , Jung Seung-Pill 
Published: April 2022

AbstractVarious experimental analyses on hydrogen evolution, absorption, and cracking behaviors were conducted to gain a fundamental understanding of the hydrogen embrittlement of ultrastrong steel sheets with galvanized (GI) and galvannealed (GA) coatings. The hydrogen evolution and absorption behaviors are controlled primarily by the potential differences between the coating and exposed steel substrate, and the corrosion-induced damage pattern of the coating. The higher absorption rate of hydrogen was more pronounced in corroded GI-coated steel caused by the larger cathodic polarization applied to the exposed substrate, and a more severe form of coating dissolution by aqueous corrosion in a 3.5% NaCl + 0.3% NH4SN solution. In contrast, the corrosive species can only penetrate through the pre-existing cracks in the brittle Fe-Zn intermetallic phases composed of the GA coating, and the driving force for hydrogen evolution becomes smaller. These result in significant differences in hydrogen penetration and cracking behaviors between the two coated ultrastrong steels.
Redefining the hypotheses driving Parkinson’s diseases research
Authors: Farrow Sophie L. , Cooper Antony A. , O’Sullivan Justin M. 
Published: April 2022

AbstractParkinson’s disease (PD) research has largely focused on the disease as a single entity centred on the development of neuronal pathology within the central nervous system. However, there is growing recognition that PD is not a single entity but instead reflects multiple diseases, in which different combinations of environmental, genetic and potential comorbid factors interact to direct individual disease trajectories. Moreover, an increasing body of recent research implicates peripheral tissues and non-neuronal cell types in the development of PD. These observations are consistent with the hypothesis that the initial causative changes for PD development need not occur in the central nervous system. Here, we discuss how the use of neuronal pathology as a shared, qualitative phenotype minimises insights into the possibility of multiple origins and aetiologies of PD. Furthermore, we discuss how considering PD as a single entity potentially impairs our understanding of the causative molecular mechanisms, approaches for patient stratification, identification of biomarkers, and the development of therapeutic approaches to PD. The clear consequence of there being distinct diseases that collectively form PD, is that there is no single biomarker or treatment for PD development or progression. We propose that diagnosis should shift away from the clinical definitions, towards biologically defined diseases that collectively form PD, to enable informative patient stratification. N-of-one type, clinical designs offer an unbiased, and agnostic approach to re-defining PD in terms of a group of many individual diseases.
Disorder-robust phase crystal in high-temperature superconductors stabilized by strong correlations
Authors: Chakraborty Debmalya , Löfwander Tomas , Fogelström Mikael , Black-Schaffer Annica M. 
Published: April 2022

AbstractThe simultaneous interplay of strong electron–electron correlations, topological zero-energy states, and disorder is yet an unexplored territory but of immense interest due to their inevitable presence in many materials. Copper oxide high-temperature superconductors (cuprates) with pair breaking edges host a flat band of topological zero-energy states, making them an ideal playground where strong correlations, topology, and disorder are strongly intertwined. Here we show that this interplay in cuprates generates a fully gapped ‘phase crystal’ state that breaks both translational and time-reversal invariance, characterized by a modulation of the d-wave superconducting phase co-existing with a modulating extended s-wave superconducting order. In contrast to conventional wisdom, we find that this phase crystal state is remarkably robust to omnipresent disorder, but only in the presence of strong correlations, thus giving a clear route to its experimental realization.
Quantum phase transition in a clean superconductor with repulsive dynamical interaction
Authors: Pimenov Dimitri , Chubukov Andrey V. 
Published: April 2022

AbstractWe consider a model of electrons at zero temperature, with a repulsive interaction which is a function of the energy transfer. Such an interaction can arise from the combination of electron–electron repulsion at high energies and the weaker electron–phonon attraction at low energies. As shown in previous works, superconductivity can develop despite the overall repulsion due to the energy dependence of the interaction, but the gap Δ(ω) must change sign at some (imaginary) frequency ω0 to counteract the repulsion. However, when the constant repulsive part of the interaction is increased, a quantum phase transition towards the normal state occurs. We show that, as the phase transition is approached, Δ and ω0 must vanish in a correlated way such that $$1/| \log [{{\Delta }}(0)]| \sim {\omega }_{0}^{2}$$

1
/
∣
log

[

Δ

(

0

)

]

∣
~

ω

0

2

. We discuss the behavior of phase fluctuations near this transition and show that the correlation between Δ(0) and ω0 locks the phase stiffness to a non-zero value.
A multi-modal open dataset for mental-disorder analysis
Authors: Cai Hanshu , Yuan Zhenqin , Gao Yiwen , Sun Shuting , Li Na , Tian Fuze , Xiao Han , Li Jianxiu , Yang Zhengwu , Li Xiaowei , Zhao Qinglin , Liu Zhenyu , Yao Zhijun , Yang Minqiang , Peng Hong , Zhu Jing , Zhang Xiaowei , Gao Guoping , Zheng Fang , Li Rui , Guo Zhihua , Ma Rong , Yang Jing , Zhang Lan , Hu Xiping , Li Yumin , Hu Bin 
Published: April 2022

AbstractAccording to the WHO, the number of mental disorder patients, especially depression patients, has overgrown and become a leading contributor to the global burden of disease. With the rising of tools such as artificial intelligence, using physiological data to explore new possible physiological indicators of mental disorder and creating new applications for mental disorder diagnosis has become a new research hot topic. We present a multi-modal open dataset for mental-disorder analysis. The dataset includes EEG and recordings of spoken language data from clinically depressed patients and matching normal controls, who were carefully diagnosed and selected by professional psychiatrists in hospitals. The EEG dataset includes data collected using a traditional 128-electrodes mounted elastic cap and a wearable 3-electrode EEG collector for pervasive computing applications. The 128-electrodes EEG signals of 53 participants were recorded as both in resting state and while doing the Dot probe tasks; the 3-electrode EEG signals of 55 participants were recorded in resting-state; the audio data of 52 participants were recorded during interviewing, reading, and picture description.
Curation of a list of chemicals in biosolids from EPA National Sewage Sludge Surveys & Biennial Review Reports
Authors: Richman Tess , Arnold Elyssa , Williams Antony J. 
Published: April 2022

AbstractSection 405(d) of the Clean Water Act requires the US Environmental Protection Agency to review sewage sludge regulations every two years to identify any additional pollutants that may occur in biosolids and to set regulations for pollutants identified in biosolids if sufficient scientific evidence shows they may harm human health or the environment. To date, EPA has conducted eight biennial reviews to identify chemical and microbial pollutants and three national sewage sludge surveys to identify pollutants and obtain concentration data for chemicals found in biosolids. Prior to 2021, there was inconsistent reporting of chemicals identified and EPA did not cumulatively track chemicals in biosolids. Through the efforts presented here, EPA produced a list of 726 chemicals and structure-based classes found in biosolids based on biennial reviews and national sewage sludge surveys. Summary statistics of concentration data are also reported for the 484 chemicals found in the three national sewage sludge surveys. The creation of the Biosolids List supports EPA in assessing the potential risk of chemical pollutants found in biosolids.
DOPAMAP, high-resolution images of dopamine 1 and 2 receptor expression in developing and adult mouse brains
Authors: Bjerke I. E. , Cullity E. R. , Kjelsberg K. , Charan K. M. , Leergaard T. B. , Kim J. H. 
Published: April 2022

AbstractThe dopaminergic system undergoes major reorganization during development, a period especially vulnerable to mental disorders. Forebrain neurons expressing dopamine 1 and 2 receptors (D1R and D2R, respectively) play a key role in this system. However, neuroanatomical information about the typical development of these neurons is sparse and scattered across publications investigating one or a few brain regions. We here present a public online collection of microscopic images of immunohistochemically stained serial sections from male and female mice at five stages of development (postnatal day 17 (P17), P25, P35, P49, and adult), showing the distribution of D1R and D2R expressing neurons across the forebrain. All images from adult brains are registered to the Allen Mouse brain Common Coordinate Framework, while images from P17-P35 age groups are registered to spatially modified atlas versions matching the morphology of young brains. This online resource provides microscopic visualization of the developing dopaminergic system in mice, which is suitable as a benchmark reference for performing new experiments and building computational models of the brain.