bluuebunny/crossref_metadata_2025_split huggingface dataset:
Der lange Weg der Stabilisierungspolitik
Authors: Landmann Oliver 
Published: October 2022

ZusammenfassungZweimal im frühen 21. Jahrhundert waren Regierungen und Zentralbanken mit drastischen Wirtschaftseinbrüchen konfrontiert und haben resolut stabilisierend eingegriffen. Dies war keine Selbstverständlichkeit. Denn Theorie und Praxis der Stabilisierungspolitik haben in den zurückliegenden 100 Jahren vielfache Wandlungen durchlaufen, in deren Zuge sich grenzenloses Vertrauen auf die Möglichkeiten der Stabilisierungspolitik immer wieder mit tiefer Skepsis abwechselte. In seinem Aufsatz gibt Oliver Landmann einen knappen Abriss dieser turbulenten Historie. Als Leitmotiv dient ihm dabei die von Keynes ins Zentrum gerückte Frage, ob die Marktwirtschaft eine inhärente Tendenz zur Selbststabilisierung („self-adjustment“) besitzt. Unterschiedliche Ansichten hierüber, geformt durch Empirie und Theorie, behielten zu unterschiedlichen Zeiten die Oberhand.
Effects of motorcycle group membership on the ride experience and travel motivators: A comparison between the USA, the UK, and Turkey
Authors: Ertaş Mehmet , Sykes Diane , Cater Carl 
Published: October 2022

Abstract
Due to the global prevalence of motorcycle tourism, this study considers the travel motivators among riders from Turkey, the United States of America, and the United Kingdom. This study adds the previously unexplored factor of group membership and its influence on travel motivators. The study used quantitative analysis of a survey that was disseminated via Google forms. The primary factors are: sense of pleasure, passion for adrenaline, and ease of riding and travel activities. Group membership was used to examine the difference among the factors. All motorcyclists ranked the factors as high as travel motivators. There were some differences among riders from different countries. Turkish riders ranked their participation in group activities higher than did the US and UK. While the US and UK and Turkey had significant differences on the sense of pleasure. This study has importance to governments, travel agencies, and businesses that serve motorcyclists.
Dysregulation of Synaptic and Developmental Transcriptomic/Proteomic Profiles upon Depletion of MUNC18-1
Authors: Van Berkel Annemiek A. , Koopmans Frank , Gonzalez-Lozano Miguel Angel , Lammertse Hanna C. A. , Feringa Femke , Bryois Julien , Sullivan Patrick F. , Smit August B. , Toonen Ruud F. , Verhage Matthijs 
Published: October 2022

AbstractAbsence of presynaptic protein MUNC18-1 (gene:Stxbp1) leads to neuronal cell death at an immature stage before synapse formation. Here, we performed transcriptomic and proteomic profiling of immatureStxbp1knock-out (KO) cells to discover which cellular processes depend on MUNC18-1. Hippocampi ofStxbp1KO mice showed cell type-specific dysregulation of 2123 transcripts primarily related to synaptic transmission and immune response. To further investigate direct, neuron-specific effects of MUNC18-1 depletion, a proteomic screen was performed on murine neuronal cultures at two developmental timepoints before onset of neuron degeneration. 399 proteins were differentially expressed, which were primarily involved in synaptic function (especially synaptic vesicle exocytosis) and neuron development. We further show that many of the downregulated proteins on loss of MUNC18-1 are normally upregulated during this developmental stage. Thus, absence of MUNC18-1 extensively dysregulates the transcriptome and proteome, primarily affecting synaptic and developmental profiles. Lack of synaptic activity is unlikely to underlie these effects, as the changes were observed in immature neurons without functional synapses, and minimal overlap was found to activity-dependent proteins. We hypothesize that presence of MUNC18-1 is essential to advance neuron development, serving as a “checkpoint” for neurons to initiate cell death in its absence.
TheSYNGAP13′UTR Variant in ALS Patients Causes AberrantSYNGAP1Splicing and Dendritic Spine Loss by Recruiting HNRNPK
Authors: Yokoi Satoshi , Ito Takuji , Sahashi Kentaro , Nakatochi Masahiro , Nakamura Ryoichi , Tohnai Genki , Fujioka Yusuke , Ishigaki Shinsuke , Udagawa Tsuyoshi , Izumi Yuishin , Morita Mitsuya , Kano Osamu , Oda Masaya , Sone Takefumi , Okano Hideyuki , Atsuta Naoki , Katsuno Masahisa , Okada Yohei , Sobue Gen 
Published: October 2022

Fused in sarcoma (FUS) is a pathogenic RNA-binding protein in amyotrophic lateral sclerosis (ALS). We previously reported that FUS stabilizes Synaptic Ras-GTPase activating protein 1 (Syngap1) mRNA at its 3′ untranslated region (UTR) and maintains spine maturation. To elucidate the pathologic roles of this mechanism in ALS patients, we identified theSYNGAP13′UTR variant rs149438267 in seven (four males and three females) out of 807 ALS patients at the FUS binding site from a multicenter cohort in Japan. Human-induced pluripotent stem cell (hiPSC)-derived motor neurons with theSYNGAP1variant showed aberrant splicing, increased isoform α1 levels, and decreased isoform γ levels, which caused dendritic spine loss. Moreover, theSYNGAP1variant excessively recruited FUS and heterogeneous nuclear ribonucleoprotein K (HNRNPK), and antisense oligonucleotides (ASOs) blocking HNRNPK altered aberrant splicing and ameliorated dendritic spine loss. These data suggest that excessive recruitment of RNA-binding proteins, especially HNRNPK, as well as changes inSYNGAP1isoforms, are crucial for spine formation in motor neurons.SIGNIFICANCE STATEMENTIt is not yet known which RNAs cause the pathogenesis of amyotrophic lateral sclerosis (ALS). We previously reported that Fused in sarcoma (FUS), a pathogenic RNA-binding protein in ALS, stabilizes synaptic Ras-GTPase activating protein 1 (Syngap1) mRNA at its 3′ untranslated region (UTR) and maintains dendritic spine maturation. To elucidate whether this mechanism is crucial for ALS, we identified theSYNGAP13′UTR variant rs149438267 at the FUS binding site. Human-induced pluripotent stem cell (hiPSC)-derived motor neurons with theSYNGAP1variant showed aberrant splicing, which caused dendritic spine loss along with excessive recruitment of FUS and heterogeneous nuclear ribonucleoprotein K (HNRNPK). Our findings that dendritic spine loss is because of excess recruitment of RNA-binding proteins provide a basis for the future exploration of ALS-related RNA-binding proteins.
Neurexin-β Mediates the Synaptogenic Activity of Amyloid Precursor Protein
Authors: Cvetkovska Vedrana , Ge Yuan , Xu Qin , Li Shaokun , Zhang Peng , Craig Ann Marie 
Published: October 2022

In addition to its role in Alzheimer's disease, amyloid precursor protein (APP) has physiological roles in synapse development and function. APP induces presynaptic differentiation when presented to axons, but the mechanism is unknown. Here we show that APP binds neurexin to mediate this synaptogenic activity. APP specifically binds β not α neurexins modulated by splice site 4. Binding to neurexin heparan sulfate glycan and LNS protein domains is required for high-affinity interaction and for full-length APP to recruit axonal neurexin. The synaptogenic activity of APP is abolished by triple knockdown of neurexins in hippocampal neurons pooled from male and female rats. Based on these and previous results, our model is that a dendritic-axonaltransdimer of full-length APP binds to axonal neurexin-β to promote synaptic differentiation and function. Furthermore, soluble sAPPs also bind neurexin-β and inhibit its interaction with neuroligin-1, raising the possibility that disruption of neurexin function by altered levels of full-length APP and its cleavage products may contribute to early synaptic deficits in Alzheimer's disease.SIGNIFICANCE STATEMENTThe prevailing model for the basis of Alzheimer's disease is the amyloid cascade triggered by altered cleavage of amyloid precursor protein (APP). APP also has physiological roles at the synapse, but the molecular basis for its synaptic functions is not well understood. Here, we show that APP binds the presynaptic organizing protein neurexin-β and that neurexin is essential for the synaptogenic activity of APP. Furthermore, soluble APP forms generated by APP cleavage also bind neurexin-β and can block interaction with transmembrane synaptogenic ligands of neurexin. These findings reveal a role for neurexin-APP interaction in synapse development and raise the possibility that disruptions of neurexin function may contribute to synaptic and cognitive deficits in the critical early stage of Alzheimer's disease.
An arrayed genome‐wide perturbation screen identifies the ribonucleoprotein Hnrnpk as rate‐limiting for prion propagation
Authors: Avar Merve , Heinzer Daniel , Thackray Alana M , Liu Yingjun , Hruska‐Plochan Marian , Sellitto Stefano , Schaper Elke , Pease Daniel P , Yin Jiang‐An , Lakkaraju Asvin KK , Emmenegger Marc , Losa Marco , Chincisan Andra , Hornemann Simone , Polymenidou Magdalini , Bujdoso Raymond , Aguzzi Adriano 
Published: October 2022

AbstractA defining characteristic of mammalian prions is their capacity for self‐sustained propagation. Theoretical considerations and experimental evidence suggest that prion propagation is modulated by cell‐autonomous and non‐autonomous modifiers. Using a novel quantitative phospholipase protection assay (QUIPPER) for high‐throughput prion measurements, we performed an arrayed genome‐wide RNA interference (RNAi) screen aimed at detecting cellular host‐factors that can modify prion propagation. We exposed prion‐infected cells in high‐density microplates to 35,364 ternary pools of 52,746 siRNAs targeting 17,582 genes representing the majority of the mouse protein‐coding transcriptome. We identified 1,191 modulators of prion propagation. While 1,151 modified the expression of both the pathological prion protein, PrPSc, and its cellular counterpart, PrPC, 40 genes selectively affected PrPSc. Of the latter 40 genes, 20 augmented prion production when suppressed. A prominent limiter of prion propagation was the heterogeneous nuclear ribonucleoprotein Hnrnpk. Psammaplysene A (PSA), which binds Hnrnpk, reduced prion levels in cultured cells and protected them from cytotoxicity. PSA also reduced prion levels in infected cerebellar organotypic slices and alleviated locomotor deficits in prion‐infected Drosophila melanogaster expressing ovine PrPC. Hence, genome‐wide QUIPPER‐based perturbations can discover actionable cellular pathways involved in prion propagation. Further, the unexpected identification of a prion‐controlling ribonucleoprotein suggests a role for RNA in the generation of infectious prions.
Diseño de herramientas pedagógicas mediadas por las TIC para fortalecer procesos de educación inclusiva: Centro de Servicios Financieros SENA
Authors: Guerrero William Alberto , Gómez Miranda Nidia Johana , Portilla Moreno Diana Liceth , Bedoya Salcedo Adelaida 
Published: October 2022

Según datos del Ministerio del Interior de la República de Colombia, en la actualidad más de 1 300 000 de ciudadanos presentan algún tipo de discapacidad. No obstante, no ha sido prioridad para el Gobierno Nacional la atención de dicha población, más aún cuando de formación en centros de educación superior se trata. En consecuencia, el imperativo moral de los educadores debe ser velar por la educación inclusiva. El presente trabajo tiene como objetivo principal diseñar herramientas pedagógicas mediadas por las TIC para fortalecer los procesos de educación inclusiva en los instructores del Centro de Servicios Financieros del Servicio Nacional de Aprendizaje (SENA). Esta metodología puede ser usada como guía en otras organizaciones que necesiten implementar la educación inclusiva.
PENGAWASAN LEGISLASI DAERAH OLEH DPD: TANTANGAN ERA DISRUPSI HUKUM
Authors: Nainggolan Indra L 
Published: October 2022

Control authority of the DPD in Article 22D of the 1945 Constitution of the Republic of Indonesia has expanded to include regional law products, both draft regional regulations, and regional regulations. Control referred to in Article 249 paragraph 1 letter j of Law No. 2 of 2018 is not a legislative review or cancellation of regional regulations. Monitoring and evaluation of draft regional regulations and regional regulations by the DPD is a broad interpretation of the legislative function, control function, and representation function. Monitoring and evaluation of regional regulations and regional regulations will ultimately carry out the function of regional representation. Regions in the context of a unitary state have representatives at the center to fight for their aspirations which are outlined in the form of national policies. Such a position makes the DPD have a major role in carrying out its representation as external control of draft regional regulations and regional regulations. The era of legal disruption demands a more responsive and innovative role for the DPD in carrying out various regional aspirations. The control practices carried out should not use the old method which is actually considered to hinder the implementation of the authority it has. The research method used is normative juridical by using library research.Keywords: Control; Draft Regional Regulations; Regional Regulations; Legal Disruption AbstrakKewenangan pengawasan DPD pada pasal 22D UUD NRI 1945 berkembang luas hingga pada produk hukum daerah baik ranperda dan perda. Pengawasan yang dimaksud pada pasal 249 ayat 1 huruf j UU No.2 Tahun 2018 bukanlah legislative review atau pembatalan peraturan daerah. Pemantauan dan evaluasi atas rancangan peraturan daerah dan peraturan daerah oleh DPD merupakan intrepretasi luas dari fungsi legislasi, fungsi pengawasan, dan fungsi representasi. Pemantauan dan evaluasi ranperda dan perda pada akhirnya melaksanakan fungsi keterwakilan daerah. Daerah dalam konteks negara kesatuan memiliki perwakilan di pusat guna memperjuangkan aspirasinya yang dituangkan dalam bentuk kebijakan nasional. Posisi demikian membuat DPD memiliki peran besar dalam menjalankan keterwakilannya sebagai pengawas eksternal terhadap ranperda dan perda. Era disrupsi hukum menuntut peran DPD lebih responsif dan inovatif dalam menjalankan aspirasi daerah yang beragam. Praktik pengawasan yang dilakukan jangan sampai menggunakan cara lama yang justru dianggap menghambat pelaksanaan kewenangan yang dimilikinya. Metode penelitian yang digunakan yuridis normatif dengan menggunakan studi kepustakaan.Keyword: Pengawasan; Ranperda; Perda; Disrupsi Hukum
Perlindungan Hukum Penerima Fidusia Terhadap Wanprestasi Yang Dilakukan Oleh Pemberi Fidusia Pada Jaminan Fidusia
Authors: Syafrida Syafrida , Hartati Ralang , Sinaga Hasudung 
Published: October 2022

Fiduciary rights are material rights that provide guarantees. The purpose of writing is to find out the legal protection for fiduciary recipients if the fiduciary giver is in default. The research method used is library research using secondary data in the form of primary legal materials, secondary legal materials and tertiary legal materials. The research is juridical normative. Fiduciary guarantee certificates provide legal protection for fiduciary recipients if the fiduciary giver defaults. The fiduciary recipient can sell on his own power the object that is the object of the fiduciary guarantee for the settlement of his receivables. Irah Irah's fiduciary certificate "For the sake of Justice Based on God Almighty" has the same legal force as a judge's decision with the power to carry out forced executions. The sale of collateral objects can be carried out under the hand based on the agreement of both parties at a high price that is mutually beneficial to both parties.Keywords: Legal Protection; Fiduciary Recipient; Default AbstrakFidusia merupakan hak kebendaan yang bersifat memberikan jamian. Tujuan penulisan untuk mengetahui perlindungan hukum terhadap penerima fidusia apabila pemberi Fidusia melakukan wanprestasi. Metode penelitian yang digunakan adalan penelitian kepustakaan menggunaan data sekunder berupa bahan hukum primer, bahan hukum sekunder dan bahan hukum tersier. Penelitian bersifat yuridis normatif. Sertifikat jaminan fidusia memberikan perlindungan hukum terhadap penerima fidusia apabila pemberi fidusia melakukan wanprestasi. Penerima fidusia dapat menjual atas kekuasaan sendiri benda yang menjadi objek jaminan fidusia untuk pelunasan piutangnya. Sertifikat fidusia Irah irah “ Demi Keadilan Berdasarkan Ketuhanan Yang Maha Esa” kekuatan hukumnnya sama dengan putusan hakim berkekuatan tetap dilakukan eksekusi paksa. Penjualan objek jaminan dapat dilakukan dibawah tangan berdasarkan kesepakatan kedua belah pihak dengan harga yang tinggi yang saling menguntungkan kedua belah pihak.Kata kunci: Perlindungan Hukum; Penerima Fidusia; Wanprestasi
Dispensasi Nikah Pada Masa Pandemi: Pasca UU Nomor 16 Tahun 2019 dan Undang-Undang Perlindungan Anak di Pengadilan Agama Indramayu-Jawa Barat
Authors: Kamarusdiana Kamarusdiana 
Published: October 2022

Penelitian ini bertujuan untuk mengetahui faktor-faktor yang melatar belakangi masyarakat Indramayu mengajukan dispensasi nikah serta dasar hukum hakim dalam menetapkan dispensasi nikah di Pengadilan Agama Indramayu dan menganalisis penetapan putusan perkara dispensasi nikah dari perspektif Undang-Undang Perlindungan anak.. Penelitian ini menggunakan pendekatan undang-undang, data kasus dispensasi nikah dan pendekatan konseptual. Adapun jenis penelitian yang digunakan adalah kualitatif. Sumber data primer diperoleh dari data putusan perkara dispensasi nikah di Pengadilan Agama Indramayu. Data lain diperoleh dari wawancara hakim dan para ahli dan sumber data lain yang terkait dengan dispensasi nikah di Pengadilan Agama Indramayu. Sedangkan data sekunder diperoleh dari data-data resmi di Pengadilan Agama Indramayu, literatur-literatur serta tulisan-tulisan tentang dispensasi nikah.Hasil penelitian ini ditemukan bahwa faktor terbesar penyebab sejumlah masyarakat Indramayu mengajukan dispensasi nikah adalah karena alasan hamil terlebih dahulu, pergaulan intim dan khawatir terjadi perbuatan yang terlarang serta telah mendapat restu dari orang tua dan keluarga. Terdapat tiga pasal yang mendasar yang menjadi dasar pertimbangan hakim dalam memutuskan perkara dispensasi nikah, yaitu Pasal 8 UU No. 1 tahun 1974 jo Pasal 39 Kompilasi Hukum Islam, Pasal 89 UU No. 7 tahun 1989 sebagaimana telah diubah dengan UU No. 3 Tahun 2006 dan perubahan kedua dengan UU Nomor 50 tahun 2009, dan Pasal 7 ayat (2) UU No. 1 tahun 1974. dalam perspektif Undang-Undang Perlindungan Anak, dispensasi nikah diantaranya melanggar ketentuan Pasal 3 Undang-Undang Nomor 23 tahun 2002.
Legal Certainty in the Application of the Crime of Narcotics Abuse Judging from the Disparity of Judges' Decisions
Authors: Suhendar Suhendar , Rezki Annissa , Yunus Nur Rohim 
Published: October 2022

Efforts to eradicate drug crimes present a law that has criminal sanctions, namely Law Number 35 of 2009 concerning Narcotics (abbreviated as the Narcotics Law) that criminal sanctions in the Narcotics Law are one of them with a death penalty. The Narcotics Law regulates the policy of criminal sanctions for drug abusers which are divided into two categories, namely the perpetrators as “Users” and/or “Dealers”. It is possible for perpetrators as dealers to be subject to the most severe criminal sanctions in the form of capital punishment as regulated in Article 114 paragraph (2). The method of legal discovery (rechtsvinding) that is often used by judges is the method of interpretation or interpretation. The results of the study state that the interpretation of the provisions that have been stated expressly must not deviate from the intent of the legislators. The judge has the authority to interpret the law if the content of the article used is unclear or incomplete. Analytical interpretation in the field of criminal law is prohibited insofar as it makes a formulation of the offense to be expanded. Analogous interpretation is permitted if it is used to fill the voids contained in the law because it has not been regulated in the provisions of the law.Keywords: Disparity; Judge; Drugs AbstrakUpaya untuk memberantas kejahatan narkoba menghadirkan sebuah Undang-Undang yang memiliki sanksi pidana yaitu Undang-Undang Nomor 35 Tahun 2009 tentang Narkotika (disingkat UU Narkotika) bahwa Sanksi Pidana dalam Undang-Undang Narkotika salah satunya adalah sanksi pidana mati. Undang-Undang Narkotika mengatur mengenai kebijakan sanksi pidana bagi pelaku penyalahguna narkoba yang dibagi kedalam dua kategori yaitu pelaku sebagai “Pengguna” dan/atau “Pengedar”. Terhadap pelaku sebagai pengedar dimungkinkan dikenakan sanksi pidana yang paling berat berupa pidana mati seperti yang diatur dalam Pasal 114 ayat (2). Metode penemuan hukum (rechtsvinding) yang sering digunakan hakim yaitu metode interpretasi atau penafsiran. Hasil penelitian menyatakan bahwa Penafsiran terhadap ketentuan yang telah dinyatakan dengan tegas tidaklah boleh menyimpang dari maksud pembentuk Undang-Undang. Hakim mempunyai kewenangan untuk melakukan penafsiran hukum apabila isi pasal yang digunakan tidak jelas atau kurang lengkap. Penafsiran secara analogis di dalam lapangan hukum pidana terlarang sejauh ia membuat suatu rumusan delik itu menjadi diperluas. Penafsiran secara analogi diizinkan apabila digunakan untuk mengisi kekosongan-kekosongan yang terdapat di dalam Undang-Undang karena belum diatur dalam ketentuan Undang-Undang tersebut.Kata Kunci: Disparitas; Hakim; Narkoba
Strategi Pengurus Masjid dalam Memakmurkan Masjid Al-Furqon di Haurgeulis Indramayu
Authors: Suhariyanti Suhariyanti , Sobirin Sobirin 
Published: October 2022

To prosper the mosque requires a good strategy, with a good strategy the program of mosque activities can run effectively and efficiently to achieve the goal of broadcasting Islam and its prosperity. The purpose of the study was to find out how the mosque management strategy in prospering the Al-Furqon mosque in Haurgeulis Indramayu. This research is a field research. This study uses a qualitative research method, with a literature and empirical approach, interview data collection techniques, observation and documentation. The results of the research on the strategies used by mosque administrators in prospering the Al-Furqon Mosque are using socialization strategies for the congregation through a door-to-door approach, and social programs for the congregation so that the congregation can be directed to participate in activities held in the congregation. Al-Furqon Mosque.Keywords: Strategy; Mosque Management; Prospering Mosque. AbstrakUntuk memakmurkan masjid memerlukan strategi yang baik, dengan strategi yang baik program kegiatan masjid dapat berjalan efektif dan efisien untuk mencapai tujuan dalam menyiarkan Islam dan kemakmurannya. Tujuan penelitian untuk mengetahui bagaimana strategi pengurus masjid dalam memakmurkan masjid Al-Furqon di Haurgeulis Indramayu. Penelitian ini menggunakan metode penelitian Kualitatif, dengan pendekatan literatur dan empiris, teknik pengumpulan data wawancara, observasi dan dokumentasi. Hasil penelitian strategi yang digunakan oleh pengurus masjid dalam memakmurkan Masjid Al-Furqon adalah menggunakan strategi sosialisasi pada jama’ah melalui pendekatan dari rumah ke rumah, dan program sosial terhadap jama’ah sehingga jama’ah dapat diarahkan untuk mengikuti kegiatan-kegiatan yang diadakan di masjid Al-Furqon.Kata Kunci: Strategi; Pengurus Masjid; Memakmurkan Masjid