bluuebunny/crossref_metadata_2025_split huggingface dataset:
Harnessing the untapped potential of indigenous cow milk in producing set-type yoghurts: case of Thamankaduwa White and Lankan cattle
Authors: Weerasingha Viraj , Priyashantha Hasitha , Ranadheera Chaminda Senaka , Prasanna Pradeep , Silva Pradeepa , Vidanarachchi Janak K. 
Published: November 2022

AbstractThis research paper assessed textural, microstructural, sensory and colour properties of set-yoghurts produced using milk from two indigenous cattle types, Thamankaduwa White (TW) and Lankan cattle (LC) compared to two generic cattle breeds, Friesian and Jersey. Instrumental texture profile (firmness, adhesiveness, cohesiveness and springiness), colour space (L* a* b*) and scanning electron micrographs of set-yoghurts during 21 d of storage (4 ± 1°C) were evaluated. Sensory quality attributes were evaluated with 40 untrained panellists using a five-point hedonic scale. Set-yoghurts prepared using indigenous cow milk showed higher (P < 0.05) firmness, cohesiveness and apparent viscosity values compared to those prepared using generic cow milk. As revealed by micrographs, set-yoghurts made from TW milk had lesser and smaller void spaces and a dense protein gel network than gels made from LC and the two generic breeds. The gel network made from Friesian milk showed a comparatively larger porous gel structure and thinner protein strands resulting in a weaker gel than other milk gels. The highest lightness (L*) and yellowness (b*) were observed from set-yoghurt produced from Friesian and LC milk, respectively. Set-yoghurts from TW milk had the highest (P < 0.05) sensory scores for all sensory attributes. The lowest sensory acceptance was recorded in set-yoghurt made from Friesian milk. Thus, milk from TW and LC is likely to be suitable in producing set-yoghurts with superior textural, microstructural and sensory properties, compared to milk from Jersey and Friesian. Our results suggest the merits of using indigenous cow milk in producing set-yoghurts and, thereby, prioritizing the preservation of the genetic pool of these indigenous breeds.
Is There a Trade-off Between Protecting Investors and Promoting Entrepreneurial Activity? Evidence from Angel Financing
Authors: Xu Jiajie 
Published: November 2022

AbstractThis article studies how changes in investor protection regulations affect local entrepreneurial activity, relying on the heterogeneous impact of a 2011 SEC regulation change on the definition of accredited investors across U.S. cities. Using a difference-in-differences approach, I show that cities more affected by the regulation change experienced a significantly larger decrease in local angel financing, entrepreneurial activity, innovation output, employment, and sales. I find that small business loans and second-lien mortgages became entrepreneurs’ partial substitutes for angel investment. My cost-benefit analysis suggests that the costs of protecting angel investors through the 2011 regulation change outweigh its benefits.
Discrete soft actor-critic with auto-encoder on vascular robotic system
Authors: Li Hao , Zhou Xiao-Hu , Xie Xiao-Liang , Liu Shi-Qi , Gui Mei-Jiang , Xiang Tian-Yu , Wang Jin-Li , Hou Zeng-Guang 
Published: November 2022

AbstractInstrument delivery is critical part in vascular intervention surgery. Due to the soft-body structure of instruments, the relationship between manipulation commands and instrument motion is non-linear, making instrument delivery challenging and time-consuming. Reinforcement learning has the potential to learn manipulation skills and automate instrument delivery with enhanced success rates and reduced workload of physicians. However, due to the sample inefficiency when using high-dimensional images, existing reinforcement learning algorithms are limited on realistic vascular robotic systems. To alleviate this problem, this paper proposes discrete soft actor-critic with auto-encoder (DSAC-AE) that augments SAC-discrete with an auxiliary reconstruction task. The algorithm is applied with distributed sample collection and parameter update in a robot-assisted preclinical environment. Experimental results indicate that guidewire delivery can be automatically implemented after 50k sampling steps in less than 15 h, demonstrating the proposed algorithm has the great potential to learn manipulation skill for vascular robotic systems.
“We’ve All Lost So Much”: The Long-Term Care Home Experiences of Essential Family Caregivers During COVID-19
Authors: Chu Charlene H. , Yee Amanda V. , Stamatopoulos Vivian 
Published: November 2022

AbstractBackgroundDuring the coronavirus (COVID-19) pandemic, long-term care homes (LTCHs) imposed visitor restrictions that prevented essential family caregivers (EFCs) from entering the homes. Under these policies, EFCs had to engage in virtual, window, and outdoor visits, prior to the re-initiation of indoor visits.ObjectiveTo understand EFCs’ visitation experiences with LTCH residents during COVID-19.MethodsSeven virtual focus groups with EFCs were conducted and analysed using a thematic approach.FindingsSix themes were identified: (a) inconsistent and poor communication; (b) lack of staffing and resources; (c) increasing discord between EFCs and staff during COVID-19; (d) shock related to reunification; (e) lack of a person-centred or family-centred approach; and, (f) EFC and resident relationships as collateral damage.DiscussionOur findings reflect how EFCs’ visitation experiences were affected by factors at the individual, LTCH, and health-system levels. Future sectoral responses and visitation guidelines should recognize EFCs as an integral part of the care team.
Diagnosis of acute cystitis in primary care: symptom-based versus urinalysis-based diagnosis
Authors: Lelie- van der Zande Rian , Koster Ellen S. , Grol Marion , Naber Kurt G. , Alidjanov Jakhongir F. , Teichert Martina , Bouvy Marcel L. 
Published: November 2022

Abstract

Aim:
This study aimed to provide insight into the congruity of acute cystitis (AC) diagnosis in women, measured both by the Acute Cystitis Symptom Score (ACSS) questionnaire and urine test(s).

Background:
The ACSS questionnaire was developed as a self-administering tool for assessing urinary symptoms, quality of life (QoL) and treatment outcomes in healthy, nonpregnant female patients.

Methods:
This prospective observational cohort study compared AC diagnosis based on the questionnaire with a GP diagnosis based on dipstick/dipslide test(s). ACSS questionnaire form A (typical and differential symptoms, QoL and relevant conditions) was filled in by the patient group, women suspected for AC visiting a GP practice with a urine sample, and the reference group, women visiting a community pharmacy for any medication. Analyses were performed assuming that the GP diagnosis based on urine test(s) was correct. Divergent result(s) of urine test(s) and ACSS questionnaire were analysed for scores of all individual questionnaire domains. Statistical analyses included descriptive statistics and the positive predictive value (PPV) and the negative predictive value (NPV) of the ACSS questionnaire and the urine test(s).

Findings:
In the patient group, 59 women were included, 38 of whom a GP positively diagnosed for AC. The reference group included 70 women. The PPV of the ACSS questionnaire was 77.3%, and the NPV was 73.3%. Analysis of patient data for divergent results showed that differential symptoms, QoL and relevant conditions explained false-positive and false-negative results. Revised results (most probable diagnosis) based on this analysis showed a PPV and NPV of 88.6% and 73.3% for the ACSS questionnaire and 100% and 76.2% for the urine test(s). For use in primary care, a reduction in false-positive and false-negative results can be achieved by including scores for differential symptoms, QoL and relevant conditions, alongside a total typical symptoms score of 6 or higher.
Self‐Similarity of Seismic Moment Release to Volume Change Scaling for Volcanoes: A Comparison With Injection‐Induced Seismicity
Authors: Kettlety Tom , Kendall J. Michael , Roman Diana C. 
Published: November 2022

AbstractEstimates of intruded magma volume are critical for forecasting volcanic unrest. Geodetic modeling can provide such estimates but is of limited use in submarine and highly vegetated settings. A complementary approach could be to use estimates of seismic moment release. In this study, we examine the moment‐volume scaling of several proximal volcanic earthquake sequences and compare it to that of injection‐induced seismicity. We find a notable similarity in scaling between the volcanic sequences, which contrasts with the broad range of responses exhibited by anthropogenic injection‐induced sequences. This may imply an underlying similarity in the geologic conditions for volcanoes that is distinct from induced seismicity settings. It could also allow for estimates of intruded volume to be made without geodetic information. This provides further insight into the factors controlling seismogenesis in these different settings and has implications for volcano seismology and injection‐induced seismicity hazard estimation.
Anthropogenic Contributions to the 2021 Pacific Northwest Heatwave
Authors: Bercos‐Hickey Emily , O’Brien Travis A. , Wehner Michael F. , Zhang Likun , Patricola Christina M. , Huang Huanping , Risser Mark D. 
Published: November 2022

AbstractDaily maximum temperatures during the 2021 heatwave in the Pacific Northwest United States and Canada shattered century old records. Multiple causal factors, including anthropogenic climate change, contributed to these high temperatures, challenging traditional methods of attributing human influence. We demonstrate that the observed 2021 daily maximum temperatures are far above the bounds of Generalized Extreme Value distributions fitted from historical data. Hence, confidence in Granger causal inference statements about the human influence on this heatwave is low. Alternatively, we present a more conditional hindcast attribution study using two regional models. We performed ensembles of simulations of the heatwave to investigate how the event would have changed if it had occurred without anthropogenic climate change and with future warming. We found that global warming caused a ∼0.8°C–1°C increase in heatwave temperatures. Future warming would lead to a ∼5°C increase in heatwave temperature by the end of the 21st century.
Derivation of Emissions From Satellite‐Observed Column Amounts and Its Application to TROPOMI NO2 and CO Observations
Authors: Sun Kang 
Published: November 2022

AbstractA unified framework that connects emissions with satellite‐observed column amounts is derived from first principles. The emission information originates from the inner product of the horizontal wind and the gradient of column amount, which is more accurate than the horizontal flux divergence as used in previous studies. Additionally, the topographical and chemical effects are accounted for through fitted scale height and chemical lifetime. This framework is applied to derive NOx and CO emissions over the CONUS from TROPOspheric Monitoring Instrument NO2 and CO observations. High‐resolution (0.04°) emission mapping over the CONUS reveals unprecedented details, including CO emissions in major cities and NOx emissions from large cities, power plants, and major roadways. Monthly resolved NOx emissions show decrease and rebound after the COVID‐19 pandemic. This framework is integrated with the physical oversampling algorithm and can be readily applied to other products from the new‐generation satellite instruments.
Magmatic and Tectonic Domains of Central Costa Rica and the Irazú‐Turrialba Volcanic Complex Revealed by Ambient Noise Tomography
Authors: Jiwani‐Brown Elliot Amir , Planès Thomas , Pacheco Javier Francisco , Mora Mauricio M. , Lupi Matteo 
Published: November 2022

AbstractThe Central America Volcanic Arc runs from Guatemala to Panama, locally interrupted in Costa Rica after the twin‐system Irazú‐Turrialba Volcanic Complex, at the onset of the Talamanca Cordillera. A marked geological discontinuity characterizes the transition between the volcanic arc and this continental mountain range. To shed light on the spatial and structural relationships between active tectonics and volcanism, we deployed a temporary network consisting of 20 broadband seismic stations around the Irazú‐Turrialba Volcanic Complex that integrated the national seismic networks maintained by Costa Rican institutes. From the seismic records, we extract cross‐correlation functions and Rayleigh wave group‐velocity dispersion curves to perform two ambient noise tomographies at a regional and local scale. From this, we derive two models that point out the magmatic and tectonic features of the southern part of the Central American Volcanic Arc and of the Irazú‐Turrialba Volcanic Complex. The regional‐scale tomographic inversion suggests that such a volcanic complex shares a common reservoir at about 5–7 km depth that is fed by a sub‐vertical region, departing from at least 12 km depth. From here magmas appear to be transported upwards and stored in separate reservoirs below each volcanic edifice. Our study establishes an improved understanding of the spatial relationship between tectonic features and distribution of magmatic reservoirs underpinning the plumbing system of the Irazú‐Turrialba volcanic complex.
PCRCR complex is essential for invasion of human erythrocytes by Plasmodium falciparum
Authors: Scally Stephen W. , Triglia Tony , Evelyn Cindy , Seager Benjamin A. , Pasternak Michał , Lim Pailene S. , Healer Julie , Geoghegan Niall D. , Adair Amy , Tham Wai-Hong , Dagley Laura F. , Rogers Kelly L. , Cowman Alan F. 
Published: November 2022

AbstractThe most severe form of malaria is caused by Plasmodium falciparum. These parasites invade human erythrocytes, and an essential step in this process involves the ligand PfRh5, which forms a complex with cysteine-rich protective antigen (CyRPA) and PfRh5-interacting protein (PfRipr) (RCR complex) and binds basigin on the host cell. We identified a heteromeric disulfide-linked complex consisting of P. falciparum Plasmodium thrombospondin-related apical merozoite protein (PfPTRAMP) and P. falciparum cysteine-rich small secreted protein (PfCSS) and have shown that it binds RCR to form a pentameric complex, PCRCR. Using P. falciparum lines with conditional knockouts, invasion inhibitory nanobodies to both PfPTRAMP and PfCSS, and lattice light-sheet microscopy, we show that they are essential for merozoite invasion. The PCRCR complex functions to anchor the contact between merozoite and erythrocyte membranes brought together by strong parasite deformations. We solved the structure of nanobody–PfCSS complexes to identify an inhibitory epitope. Our results define the function of the PCRCR complex and identify invasion neutralizing epitopes providing a roadmap for structure-guided development of these proteins for a blood stage malaria vaccine.
Evidence, detailed characterization and clinical context of complement activation in acute multisystem inflammatory syndrome in children
Authors: Sinkovits György , Schnur János , Hurler Lisa , Kiszel Petra , Prohászka Zita Z. , Sík Pál , Kajdácsi Erika , Cervenak László , Maráczi Veronika , Dávid Máté , Zsigmond Borbála , Rimanóczy Éva , Bereczki Csaba , Willems Loek , Toonen Erik J. M. , Prohászka Zoltán 
Published: November 2022

AbstractMultisystem inflammatory syndrome in children (MIS-C) is a rare, life-threatening complication of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. MIS-C develops with high fever, marked inflammation and shock-like picture several weeks after exposure to, or mild infection with SARS-CoV-2. Deep immune profiling identified activated macrophages, neutrophils, B-plasmablasts and CD8 + T cells as key determinants of pathogenesis together with multiple inflammatory markers. The disease rapidly responds to intravenous immunoglobulin (IVIG) treatment with clear changes of immune features. Here we present the results of a comprehensive analysis of the complement system in the context of MIS-C activity and describe characteristic changes during IVIG treatment. We show that activation markers of the classical, alternative and terminal pathways are highly elevated, that the activation is largely independent of anti-SARS-CoV-2 humoral immune response, but is strongly associated with markers of macrophage activation. Decrease of complement activation is closely associated with rapid improvement of MIS-C after IVIG treatment.
Comparison of nutritional risk screening with NRS2002 and the GLIM diagnostic criteria for malnutrition in hospitalized patients
Authors: Trollebø Marte A. , Skeie Eli , Revheim Ingrid , Stangeland Helene , Erstein Mari-Anne H. , Grønning Martin K. , Tangvik Randi J. , Morken Mette H. , Nygård Ottar , Eagan Tomas M. L. , Rosendahl-Riise Hanne , Dierkes Jutta 
Published: November 2022

AbstractNutritional risk screening, to identify patients at risk of malnutrition, is the first step in the prevention and treatment of malnutrition in hospitalized patients, and should be followed by a thorough nutritional assessment resulting in a diagnosis of malnutrition and subsequent treatment. In 2019, a consensus on criteria has been suggested for the diagnosis of malnutrition by the Global Leadership Initiative for Malnutrition (GLIM). This study investigates the diagnosis of malnutrition in hospitalized patients using nutritional risk screening and the diagnostic assessment suggested by GLIM. Hospitalized patients (excluding cancer, intensive care, and transmissible infections) who underwent nutritional risk screening (by NRS2002) were included. Nutritional risk screening was followed by anthropometric measurements including measurement of muscle mass, assessment of dietary intake and measurement of serum C-reactive protein (CRP) for inflammation in all patients. Malnutrition was diagnosed according to the GLIM-criteria. In total, 328 patients (median age 71 years, 47% women, median length of stay 7 days) were included. Nutritional risk screening identified 143 patients as at risk of malnutrition, while GLIM criteria led to a diagnosis of malnutrition in 114 patients. Of these 114 patients, 77 were also identified as at risk of malnutrition by NRS2002, while 37 patients were not identified by NRS2002. Malnutrition was evident in fewer patients than at risk of malnutrition, as expected. However, a number of patients were malnourished who were not identified by the screening procedure. More studies should investigate the importance of inflammation and reduced muscle mass, which is the main difference between nutritional risk screening and GLIM diagnostic assessment.
Comprehensive evaluation model for health grade of multi-component compound release materials based on fuzzy comprehensive evaluation with grey relational analysis
Authors: Wang Qifan , Du Jianhui , Shen Jun , Wang Yiming 
Published: November 2022

AbstractThe selection of materials is a complex and elusive process due to the multiple factors related to health. For the effective selection of materials, a comprehensive model for evaluating the health grade of materials was proposed with the mathematical method of the fuzzy comprehensive evaluation (FCE) and grey relational analysis (GRA). A health evaluation procedure scheme of the AgBB as well as standards of the forestry industry of the People’s Republic of China and standards of the health industry of the People’s Republic of China were referred to during the process. Based on Qt technology, a computer program was developed to calculate the compound comprehensive evaluation models. The data ofChoerospondias axillariswith different lacquers were used as practical examples firstly, and then, the emission and odor characteristics ofXylosma racemosum(Sieb. et Zucc.) Miq. with PU, UV, and waterborne coating were explored with the technology of GC–MS/O. Results showed that: a total of 21 odorants were identified fromXylosma racemosumwith PU, UV, and waterborne coating. The health grade of threeXylosma racemosumsamples was UV > waterborne > PU, with the health grade of UV coating being “A”, and the boards with PU and the waterborne coating were “N”, with a fuzzy comprehensive index ofPPU = 0.5151,Pwaterborne coatings=0.4950. Based on the results, it is proved that the establishment of the comprehensive evaluation model based on FCE and GRA successfully converts qualitative evaluation into quantitative evaluation; in addition, effectively evaluates the health grade of materials. This study provides a better understanding of materials’ health grades, which will aid consumers in reducing indoor air pollution and using their products properly.
RETRACTED ARTICLE: Thermal cooling efficacy of a solar water pump using Oldroyd-B (aluminum alloy-titanium alloy/engine oil) hybrid nanofluid by applying new version for the model of Buongiorno
Authors: Shahzad Faisal , Jamshed Wasim , Eid Mohamed R. , Safdar Rabia , Putri Mohamed Isa Siti Suzilliana , El Din Sayed M. , Mohd Nasir Nor Ain Azeany , Iqbal Amjad 
Published: November 2022

Abstract
Solar radiation, which is emitted by the sun, is required to properly operate photovoltaic cells and solar water pumps (SWP). A parabolic trough surface collector (PTSC) installation model was created to investigate the efficacy of SWP. The thermal transfer performance in SWP is evaluated thru the presence of warmth radiation and heat cause besides viscid dissipation. This evaluation is performed by measuring the thermal transmission proportion of the selected warmth transmission liquid in the PTSC, known as a hybrid nano-fluid. Entropy analysis of Oldroyd-B hybrid nano-fluid via modified Buongiorno's model was also tested. The functions of regulating parameters are quantitatively observed by using the Keller-box approach in MATLAB coding. Short terms define various parameters for tables in velocity, shear pressure and temperature, gravity, and Nusselt numbers. In the condition of thermal radiation and thermal conductivity at room temperature, the competence of SWP is proven to be enhanced. Unlike basic nano-fluids, hybrid nano-fluids are an excellent source of heat transfer. Additionally, with at least 22.56% and 35.01% magnitude, the thermal efficiency of AA7075–Ti–6Al–4 V/EO is higher than AA7075–EO.
The critical role of dimethylamine in the rapid formation of iodic acid particles in marine areas
Authors: Ning An , Liu Ling , Zhang Shaobing , Yu Fangqun , Du Lin , Ge Maofa , Zhang Xiuhui 
Published: November 2022

AbstractMarine new particle formation (NPF) can affect cloud condensation nuclei (CCN) in the global atmosphere. Recently, iodic acid (IA) has been identified as a critical driver for marine NPF. However, atmospheric observations of IA cannot be associated with predicted particle formation rates. Given the complexity of atmospheric components, other species may promote IA particle formation. As an efficient stabilizer for acidic precursors, dimethylamine (DMA) has a wide distribution over the oceans. Hence, we investigated the nucleation process of DMA and IA under different atmospheric conditions and uncovered the corresponding nucleating mechanism using a quantum chemical approach and Atmospheric Cluster Dynamics Code (ACDC). The findings show that DMA can structurally stabilize IA via hydrogen and halogen bonds, and the clustering process is energy barrierless. Moreover, DMA can enhance the formation rate of IA clusters by five orders of magnitude, and its efficiency in promoting IA cluster formation is much higher than that of NH3. Compared to the nucleation via sequential addition of IA, the IA-DMA nucleation plays a more dominant role in nucleation kinetic. Thus, the effect of DMA on enhancing IA cluster stability and formation rate cannot be ignored, especially in the regions near the source of IA and DMA emissions. Broadly, the proposed IA-DMA nucleation mechanism may help to explain some missing sources of particles and, thus intensive marine NPF events.