bluuebunny/crossref_metadata_2025_split huggingface dataset:
Flexible Pressure Sensors Based on Bionic Microstructures: From Plants to Animals
Authors: Tan Yuewu , Liu Xuehong , Tang Wei , Chen Jing , Zhu Zhengfang , Li Lin , Zhou Nian , Kang Xiaoyang , Xu Dongliang , Wang Lei , Wang Guixue , Tan Hui , Li Hui 
Published: January 2022

AbstractNumerous wearable devices have been applied in people's daily lives. As the core component of wearable devices, flexible pressure sensors play an especially important role in various fields because of their excellent adaptability to the environment. Various high‐performance flexible pressure sensors have been developed, and much research is still being conducted to increase the performance of flexible pressure sensors. A variety of materials with excellent properties have been created, many advanced manufacturing methods have been developed, and different microstructures have been attempted and applied to flexible pressure sensors. To optimize the performance of sensors, flexible pressure sensors with bionic microstructures from the perspective of bionics have attracted increasing attention, which can bring new designs and improve the performance. This paper mainly summarizes various kinds of flexible pressure sensors with bionic structures developed in recent years. The main contents include the following parts: an introduction to the current state‐of‐the‐art flexible pressure sensors; substrate and active materials, sensing mechanisms, key parameters, and sensitivity optimization strategies; various kinds of bionic microstructures applied to flexible pressure sensors and characterization of the performance; applications of flexible pressure sensors; and prospects and potential challenges of flexible pressure sensors.
Synthesis, Catalytic Activity and Comparative Leaching Studies of Calix[8]arene‐Supported Pd‐NHC Complexes for Suzuki‐Miyaura Cross‐Couplings
Authors: Abi Fayssal Sandra , Naret Timothée , Buendia Julien , Labattut Axel , Huc Vincent , Martini Cyril , Schulz Emmanuelle 
Published: January 2022

AbstractA rapid and scalable synthesis of supported NHC−Pd(II)‐pyridine complexes on a benzyloxycalix[8]arene macrocycle is reported. Their subsequent use in Suzuki‐Miyaura benchmark reactions led to the optimisation of the nature of the ligands around the metal centre, delivering two very active precatalysts. They both promote the cross‐coupling of challenging API precursors at low catalytic loadings, when used as insoluble species in EtOH as a green reaction solvent. Moreover, their activity has been shown to be comparable or even superior to that of more conventional homogeneous catalysts. Of main importance, a simple filtration of the insoluble supported catalysts after reaction afforded the lowest Pd contamination values in the target products, in some cases directly approaching the levels authorised by the industrial regulations. Offering furthermore the possibility of easy palladium recovery in the current context of its overconsumption, we are convinced that these calixarene‐supported NHC‐PEPPSI Pd complexes are valuable tools for the fine chemical industry, to prepare metal‐free functionalised biaryl compounds in high yields, ranging from 76 to 94%.magnified image
TFAA/DMSO‐Promoted Fluorination of P(O)−H and P(O)−OH Compounds: Compatible Access to Fluorophosphonates and Phosphonofluoridates
Authors: Li Qi‐Wei , Zhang Xin‐Yue , Lu Lu , Wu Zi‐Qian , Li Ji , Li Gui‐Zhi , Sun Kai , Yang Shang‐Dong , Yang Bin 
Published: January 2022

AbstractA TFAA/DMSO/NaF‐based system for the efficient fluorination of P(O)−H and P(O)−OH compounds has been developed. Without adding highly toxic and expensive fluorination reagents, this novel transformation provides direct and compatible access to a variety of fluorophosphonates and phosphonofluoridates in a one‐pot manner.magnified image
Group 3 Innate Lymphoid Cells Protect the Host from the Uropathogenic Escherichia coli Infection in the Bladder
Authors: Huang Jiaoyan , Fu Liuhui , Huang Jida , Zhao Jie , Zhang Xin , Wang Wenyan , Liu Yeyang , Sun Bowen , Qiu Ju , Hu Xiaoyu , Liu Zhihua , Guo Xiaohuan 
Published: January 2022

AbstractInnate lymphoid cells (ILCs) are crucial in orchestrating immunity and maintaining tissue homeostasis in various barrier tissues, but whether ILCs influence immune responses in the urinary tract remains poorly understood. Here, bladder‐resident ILCs are comprehensively explored and identified their unique phenotypic and developmental characteristics. Notably, bladder‐resident ILCs rapidly respond to uropathogenic Escherichia coli (UPEC) infection. It is found that ILC3 is necessary for early protection against UPEC infection in the bladder. Mechanistically, UPEC infection leads to interleukin (IL)‐1β production in the bladder via a MyD88‐dependent pathway, which promotes ILC3 activation. ILC3‐expressed IL‐17A further recruits neutrophils and controls UPEC infection in the bladder. Together, these results demonstrate a critical role for bladder ILCs in the host defense against UPEC infection.
Strategies for Electrochemically Sustainable H2 Production in Acid
Authors: Hou Yuxi , Lv Jiangquan , Quan Weiwei , Lin Yingbin , Hong Zhensheng , Huang Yiyin 
Published: January 2022

AbstractAcidified water electrolysis with fast kinetics is widely regarded as a promising option for producing H2. The main challenge of this technique is the difficulty in realizing sustainable H2 production (SHP) because of the poor stability of most electrode catalysts, especially on the anode side, under strongly acidic and highly polarized electrochemical environments, which leads to surface corrosion and performance degradation. Research efforts focused on tuning the atomic/nano structures of catalysts have been made to address this stability issue, with only limited effectiveness because of inevitable catalyst degradation. A systems approach considering reaction types and system configurations/operations may provide innovative viewpoints and strategies for SHP, although these aspects have been overlooked thus far. This review provides an overview of acidified water electrolysis for systematic investigations of these aspects to achieve SHP. First, the fundamental principles of SHP are discussed. Then, recent advances on design of stable electrode materials are examined, and several new strategies for SHP are proposed, including fabrication of symmetrical heterogeneous electrolysis system and fluid homogeneous electrolysis system, as well as decoupling/hybrid‐governed sustainability. Finally, remaining challenges and corresponding opportunities are outlined to stimulate endeavors toward the development of advanced acidified water electrolysis techniques for SHP.
Design of shell and tube heat exchangers considering the interaction of fouling and hydraulics
Authors: Lemos Julia C. , Costa André L. H. , Bagajewicz Miguel J. 
Published: January 2022

AbstractWe extend a formulation of the heat exchanger design optimization with fouling modeling to consider the effect of fouling on hydraulics. A shell‐side fouling model was added so the optimization can consider cases with fouling in the tube and shell sides. The focus is the design of heat exchangers with fouling behavior associated with a threshold model, like in crude preheat trains. We solve the optimization problem by using a newly proposed Set Trimming technique. We compare our results with the traditional approach of using fixed fouling factors and the previous approach of not considering the hydraulic impact of fouling. We conclude that considering the deposit thickness leads to more realistic results that are different than the ones obtained using the previous approaches. Moreover, we show that previous approaches can render designs with larger pressure drops than the maximum imposed by the constraints, as well as exchangers with higher areas.
Think Big: A multinational collaboration to promote children's role as coresearchers in participatory research
Authors: Marinkovic Chavez Katitza , Gibbs Lisa , Saracostti Mahia , Lafaurie Andrea , Campbell Rona , Sweeney Dominique , Hernández María Teresa , Sotomayor María Belén , Escobar Florencia , López‐Ordosgoitia Rocío , Giraldo Cadavid Diana Alexandra , Aristizábal García Diana Marcela , Wright Marcus , Charalampopoulos Dimitrios , Miranda Edgardo , Alisic Eva 
Published: January 2022

AbstractThe field of participatory research with children developed largely thanks to shared learning between different cultures, places, and disciplines. However, grand narratives and power relationships in academia inherited from colonialism and imperialism can threaten to obstruct the transformative value of this approach. In this article, we present the case of Think Big, a multinational collaboration for participatory research with children that involved adult and child coresearchers from Australia, Chile, Colombia, and the United Kingdom. Our aim was to explore how this project helped build solidarities between adult researchers from different countries and disciplines. We applied a methodology of diffraction to explore the processes and outcomes of this collaboration and presented our insights using the metaphor of a tree to explain the roots (knowledges and frameworks), trunk (ongoing collaboration and communication between the teams from different countries), branches (local projects), and fruits (research outcomes) of our work. Based on our experience, we proposed that multinational collaborations for participatory research offer important opportunities for adult researchers to collaborate with children to generate more democratic knowledge about their lives and to generate more egalitarian relationships between adult researchers from different places and backgrounds. However, it is important to anticipate that multinational collaborations are more likely to be affected by social and political upheavals, and language barriers must be overcome to decentralize academia. Also, the organizations involved in these collaborations need to develop strategies that facilitate funding, ethics clearance, and international research agreements.
Triamcinolone‐impregnated bioabsorbable middle meatus packing following endoscopic sinus surgery: A prospective randomized controlled trial
Authors: McCormick Justin P. , Suh Jeffrey D. , Yang Hong‐Ho , Lee Jivianne T. , Wang Marilene B. 
Published: January 2022

AbstractIntroductionTopical steroids are a mainstay in the treatment of chronic rhinosinusitis (CRS). Multiple delivery methods of topical steroids following sinus surgery have been investigated. The purpose of this trial is to evaluate the effect of triamcinolone‐impregnated absorbable nasal packing on healing following endoscopic sinus surgery (ESS).MethodsThis is a prospective, randomized, double‐blind, placebo‐controlled trial. A total of 22 subjects (14 without polyps and eight with polyps) were enrolled and were randomized to receive triamcinolone‐impregnated packing in one sinus cavity and normal saline‐soaked packing in the contralateral sinus cavity. Endoscopic evaluation was completed at the first two postoperative visits, and Lund–Kennedy (LK) endoscopic scores and perioperative sinus endoscopy (POSE) scores were calculated at each visit.ResultsThe results of this study found no significant difference in the appearance of the sinuses at either postoperative visit. Mean LK scores for the triamcinolone and saline groups at the first and second postoperative visits were 2.09 ± 1.23 versus 2.18 ± 1.01 (p = 0.79) and 1.79 ± 1.08 versus 1.68 ± 1.16 (p = 0.77), respectively. POSE scores were 2.59 ± 1.71 versus 2.68 ± 1.62 (p = 0.86) and 1.74 ± 1.15 versus 1.95 ± 1.22 (p = 0.59).ConclusionThe results of this study demonstrated no significant difference in healing, crusting, polyps, edema, or secretions between the triamcinolone‐treated and non‐triamcinolone‐treated sinuses. There were no adverse effects from the use of triamcinolone‐impregnated absorbable packing. Further studies will be necessary to determine the impact of triamcinolone‐impregnated absorbable packing following ESS.
Organoplatinum(II) Cruciform: A Versatile Building Block to Fabricate 2D Microcrystals with Full‐Color and White Phosphorescence and Anisotropic Photon Transport
Authors: Xu Fa‐Feng , Zeng Wei , Sun Meng‐Jia , Gong Zhong‐Liang , Li Zhong‐Qiu , Zhao Yong Sheng , Yao Jiannian , Zhong Yu‐Wu 
Published: January 2022

AbstractConventional square‐planar platinum complexes typically form one‐dimensional assemblies as a result of unidirectional metallophilic and/or π⋅⋅⋅π intermolecular interactions. Organoplatinum(II) complexes with a cruciform shape are presented herein to construct two‐dimensional (2D) microcrystals with full‐color and white phosphorescence. These 2D crystals show unique monocomponent π⋅⋅⋅π stacking, from either the cyclometalating or noncyclometalating ligand, and the bicomponent alternate π⋅⋅⋅π stacking from both ligands along different facet directions. Anisotropic tri‐directional waveguiding is further implemented on a single hexagonal microcrystal. These results demonstrate the great capability of the organoplatinum(II) cruciform as a general platform to fabricate 2D phosphorescent micro‐/nanocrystals for advanced photonic applications.
Shifting language for shifting anatomy: Using inclusive anatomical language to support transgender and nonbinary identities
Authors: Easterling Lauren , Byram Jessica 
Published: January 2022

AbstractWhile navigating a medical or surgical gender transition, transgender, and nonbinary people encounter anatomical language and concepts through their own informal research on the topics and directly through healthcare providers. Use of appropriate and inclusive language is important for affirming identities and can be fostered at any point during professional training through modeling of inclusive language and in the formal curriculum, including during anatomical education. In this article we discuss anatomical language and how it intersects with gender identity, first from the perspective of a transgender patient, then from the perspective of an anatomy educator. The patient shared how she benefited from informative resources, nongendered language, language tailored to her level of understanding, and providers not making generalizations about her based on her anatomy or sex assigned at birth. The educator shared her experience developing a primer on sex and gender that moved beyond a prescriptive binary and exposed students to language and concepts inclusive of diverse sexual and gender identities. Recommendations were made related to how to implement these lessons and better explore how transgender and nonbinary individuals experience anatomical language and the potential impact of language that is inclusive of gender‐diverse persons in anatomical education as part of health professions programs. While sound medicine, procedure, science, and experienced professional skill were necessary, an essential positive aspect of the medical and gender transitions discussed was an intentionality around language by providers—including anatomical language.
The Emerging Roles of Silver Nanoparticles to Target Viral Life Cycle and Detect Viral Pathogens
Authors: Ghosh Ujjyani , Sayef Ahammed Khondakar , Mishra Snehasis , Bhaumik Asim 
Published: January 2022

AbstractAlong the line of recent vaccine advancements, new antiviral therapeutics are compelling to combat viral infection‐related public health crises. Several properties of silver nanoparticles (AgNPs) such as low level of cytotoxicity, ease of tunability of the AgNPs in the ultra‐small nanoscale size and shape through different convenient bottom‐up chemistry approaches, high penetration of the composite with drug formulations into host cells has made AgNPs, a promising candidate for developing antivirals. In this review, we have highlighted the recent advancements in the AgNPs based nano‐formulations to target cellular mechanisms of viral propagation, immune modulation of the host, and the ability to synergistically enhance the activity of existing antiviral drugs. On the other hand, we have discussed the recent advancements on AgNPs based detection of viral pathogens from clinical samples using inherent physicochemical properties. This article will provide an overview of our current knowledge on AgNPs based formulations that has promising potential for developing a counteractive strategy against emerging and existing viruses.
Versatility of subtilisin: A review on structure, characteristics, and applications
Authors: Azrin Nur Aliyah Mohd , Ali Mohd Shukuri Mohamad , Rahman Raja Noor Zaliha Raja Abd , Oslan Siti Nurbaya , Noor Noor Dina Muhd 
Published: January 2022

AbstractDue to its thermostability and high pH compatibility, subtilisin is most known for its role as an additive for detergents in which it is categorized as a serine protease according to MEROPS database. Subtilisin is typically isolated from various bacterial species of the Bacillus genus such as Bacillus subtilis, B. amyloliquefaciens, B. licheniformis, and various other organisms. It is composed of 268–275 amino acid residues and is initially secreted in the precursor form, preprosubtilisin, which is composed of 29‐residues signal peptide, 77‐residues propeptide, and 275‐residues active subtilisin. Subtilisin is known for the presence of high and low affinity calcium binding sites in its structure. Native subtilisin has general properties of thermostability, tolerance to neutral to high pH, broad specificity, and calcium‐dependent stability, which contribute to the versatility of subtilisin applicability. Through protein engineering and immobilization technologies, many variants of subtilisin have been generated, which increase the applicability of subtilisin in various industries including detergent, food processing and packaging, synthesis of inhibitory peptides, therapeutic, and waste management applications.
New insights into the interplay between long non‐coding RNAs and RNA‐binding proteins in cancer
Authors: Yao Zi‐Ting , Yang Yan‐Ming , Sun Miao‐Miao , He Yan , Liao Long , Chen Kui‐Sheng , Li Bin 
Published: January 2022

AbstractWith the development of proteomics and epigenetics, a large number of RNA‐binding proteins (RBPs) have been discovered in recent years, and the interaction between long non‐coding RNAs (lncRNAs) and RBPs has also received increasing attention. It is extremely important to conduct in‐depth research on the lncRNA‐RBP interaction network, especially in the context of its role in the occurrence and development of cancer. Increasing evidence has demonstrated that lncRNA‐RBP interactions play a vital role in cancer progression; therefore, targeting these interactions could provide new insights for cancer drug discovery. In this review, we discussed how lncRNAs can interact with RBPs to regulate their localization, modification, stability, and activity and discussed the effects of RBPs on the stability, transport, transcription, and localization of lncRNAs. Moreover, we explored the regulation and influence of these interactions on lncRNAs, RBPs, and downstream pathways that are related to cancer development, such as N6‐methyladenosine (m6A) modification of lncRNAs. In addition, we discussed how the lncRNA‐RBP interaction network regulates cancer cell phenotypes, such as proliferation, apoptosis, metastasis, drug resistance, immunity, tumor environment, and metabolism. Furthermore, we summarized the therapeutic strategies that target the lncRNA‐RBP interaction network. Although these treatments are still in the experimental stage and various theories and processes are still being studied, we believe that these strategies may provide new ideas for cancer treatment.
Teaching C++ programming using automated unit testing and test‐driven development—Design and efficacy study
Authors: Sheikh Waseem 
Published: January 2022

AbstractThe best practices of agile software development have had a significant positive impact on the quality of software and time‐to‐delivery. As a result, many leading software companies employ some form of agile software development practices. Some of the most important best practices of agile software development, which have received significant attention in recent years, are automated unit testing (AUT) and test‐driven development (TDD). Both of these practices work in conjunction to provide numerous benefits. AUT leads to reduced time to test, discover bugs, fix bugs, and implement new features; wider and measurable test coverage; reproducibility, reusability, consistency, and reliability of tests; improved accuracy, regression testing, parallel testing, faster feedback cycle, reduced cost, and higher team morale. The benefits of TDD include flexible and adaptive program design, cleaner interfaces, higher code quality, maintainability, extensibility, reliability, detailed evolving specification, reduced time on bug fixes and feature implementation, reliable refactoring, and code changes, reduced cost, reduced development time, and increased programmer productivity. Unfortunately, students in introductory programming courses are generally not introduced to AUT and TDD. This leads to the development of bad programming habits and practices which become harder to change later on. By introducing the students earlier to these industry‐standard best practices, not only the motivation and interest of students in this area can be increased but also their academic success and job marketability can be enhanced. This paper presents the detailed design and efficacy study of an introductory C++ programming course designed using the principles of AUT and TDD. The paper presents the pedagogical techniques employed to build industry‐proven agile software development practices in the students. As part of the paper, all the course material including the source code for the labs and the automated unit tests are being made available to encourage people to incorporate these best practices into their curricula.
Charge Matters: Mutations in Omicron Variant Favor Binding to Cells
Authors: Nie Chuanxiong , Sahoo Anil Kumar , Netz Roland R. , Herrmann Andreas , Ballauff Matthias , Haag Rainer 
Published: January 2022

AbstractEvidence is strengthening to suggest that the novel SARS‐CoV‐2 mutant Omicron, with its more than 60 mutations, will spread and dominate worldwide. Although the mutations in the spike protein are known, the molecular basis for why the additional mutations in the spike protein that have not previously occurred account for Omicron's higher infection potential, is not understood. We propose, based on chemical rational and molecular dynamics simulations, that the elevated occurrence of positively charged amino acids in certain domains of the spike protein (Delta: +4; Omicron: +5 vs. wild type) increases binding to cellular polyanionic receptors, such as heparan sulfate due to multivalent charge‐charge interactions. This observation is a starting point for targeted drug development.
Awake intubation with videolaryngoscopy and fiberoptic bronchoscope
Authors: Utada Shusuke , Okano Hiromu , Miyazaki Hiroshi , Niida Shoko , Horiuchi Hiroshi , Suzuki Naoya , Otsuka Tsuyoshi , Furuya Ryosuke 
Published: January 2022

AbstractBy combining video laryngoscopy and fiberoptic bronchoscopy, awake intubation can be performed more safely.
Cobalt‐Catalysed Reductive Etherification Using Phosphine Oxide Promoters under Hydroformylation Conditions
Authors: Delolo Fábio G. , Fessler Johannes , Neumann Helfried , Junge Kathrin , dos Santos Eduardo N. , Gusevskaya Elena V. , Beller Matthias 
Published: January 2022

AbstractA phosphine‐oxide‐promoted, cobalt‐catalysed reductive etherification using syngas as a reductant is reported. This novel methodology was successfully used to prepare a broad range of unsymmetrical ethers from various aldehydes and alcohols containing diverse functional groups, and was scaled‐up to multigram scale under comparably mild conditions. Mechanistic experiments support an acetalization–hydrogenation sequence.