bluuebunny/crossref_metadata_2025_split huggingface dataset:
Lagging coverage for mental health services among children and adolescents through home and community‐based Medicaid waivers
Authors: Keim‐Malpass Jessica , Constantoulakis Leeza , Shaw Emily K. , Letzkus Lisa C. 
Published: September 2022

AbstractProblemMany states cover mental health home and community‐based services (HCBS) for youth through 1915(c) Medicaid HCBS waivers that allow states to waive certain Medicaid eligibility criteria and define high‐risk populations based on age, medical condition(s), and disability status. We sought to evaluate how States are covering children and adolescents with mental health needs through 1915(c) waivers compared to other youth waiver populations.MethodsData elements were extracted from Medicaid 1915(c) approved waivers applications for all included waivers targeting any pediatric age range through October 31, 2018. Normalization criteria were developed and an aggregate overall coverage score and level of funding per person per waiver were calculated for each waiver.FindingsOne hundred and forty‐two waivers across 45 states were included in this analysis. Even though there was uniformity in the Medicaid applications, there was great heterogeneity in how waiver eligibility, transition plans, services covered, and wait lists were defined across group classifications. Those with mental health needs (termed serious emotional disturbance) represented 5% of waivers with the least annual funding per person per waiver.ConclusionsWe recommend greater links between public policy, infrastructure, health care providers, and a family‐centered approach to extend coverage and scope of services for children and adolescents with mental health needs.
Delta‐like ligand‐4 regulates Notch‐mediated maturation of second heart field progenitor‐derived pharyngeal arterial endothelial cells
Authors: De Zoysa Prashan , Toubat Omar , Harvey Drayton C. , Yi Christopher , Liu Jiang , Cavallero Susana , Hong Young‐Kwon , Sucov Henry M. , Kumar Subramanyan Ram 
Published: September 2022

AbstractMesodermal progenitors in the second heart field (SHF) express Delta‐like‐ligand 4 (Dll4) that regulates Notch‐mediated proliferation. As cells of SHF lineage mature to assume endocardial and myocardial cell fates, we have shown that Dll4 expression is lost, and the subsequent expression of another Notch ligand Jagged1 regulates Notch‐mediated maturation events in the developing heart. A subset of SHF progenitors also matures to form the pharyngeal arch artery (PAA) endothelium. Dll4 was originally identified as an arterial endothelial‐specific Notch ligand that plays an important role in blood vessel maturation, but its role in aortic arch maturation has not been studied to date secondary to the early lethality observed in Dll4 knockout mice. We show that, unlike in SHF‐derived endocardium and myocardium, Dll4 expression persists in SHF‐derived arterial endothelial cells. Using SHF‐specific conditional deletion of Dll4, we demonstrate that as SHF cells transition from their progenitor state to an endothelial fate, Dll4‐mediated Notch signalling switches from providing proliferative to maturation cues. Dll4 expression maintains arterial identity in the PAAs and plays a critical role in the maturation and re‐organization of the 4th pharyngeal arch artery, in particular. Haploinsufficiency of Dll4 in SHF leads to highly penetrant aortic arch artery abnormalities, similar to those observed in the clinic, primarily resulting from aberrant reorganization of bilateral 4th pharyngeal arch arteries. Hence, we show that cells of SHF lineage that assume an arterial endothelial fate continue to express Dll4 and the resulting Dll4‐mediated Notch signalling transitions from an early proliferative to a later maturation role during aortic arch development.
Family systems and obesity: A review of key concepts and influences within and between family subsystems and a call for family‐informed interventions
Authors: Novak Josh R. , Pratt Keeley , Hernandez Daphne C. , Berge Jerica M. 
Published: September 2022

AbstractResearch on the social determinants of obesity describes the importance of family dynamics and how they can influence an individual's weight and weight‐related behaviors. These proximal influences include parent–child, couple, and limited research on intergenerational and sibling dynamics. However, familial research is often isolated to one relationship subsystem (i.e., parent–child or couple) and is not integrated into the larger Family Systems Theory (FST) framework. The purpose of this paper is twofold: to present recommendations for future work by expounding on FST concepts for weight management and obesity prevention, and to provide a review of the theoretical and empirical evidence for each family system and subsystem, including (a) the extended family, (b) family environment, (c) couple, (d) parent–child, and (e) sibling, and present methodological and analytical considerations.
The transcriptional co‐repressor SEED DORMANCY 4‐LIKE (AtSDR4L) promotes the embryonic‐to‐vegetative transition in Arabidopsis thaliana
Authors: Wu Ting , Alizadeh Milad , Lu Bailan , Cheng Jinkui , Hoy Ryan , Bu Miaoyu , Laqua Emma , Tang Dongxue , He Junna , Go Dongeun , Gong Zhizhong , Song Liang 
Published: September 2022

ABSTRACTRepression of embryonic traits during the seed‐to‐seedling phase transition requires the inactivation of master transcription factors associated with embryogenesis. How the timing of such inactivation is controlled is unclear. Here, we report on a novel transcriptional co‐repressor, Arabidopsis thaliana SDR4L, that forms a feedback inhibition loop with the master transcription factors LEC1 and ABI3 to repress embryonic traits post‐imbibition. LEC1 and ABI3 regulate their own expression by inducing AtSDR4L during mid to late embryogenesis. AtSDR4L binds to sites upstream of LEC1 and ABI4, and these transcripts are upregulated in Atsdr4l seedlings. Atsdr4l seedlings phenocopy a LEC1 overexpressor. The embryonic traits of Atsdr4l can be partially rescued by impairing LEC1 or ABI3. The penetrance and expressivity of the Atsdr4l phenotypes depend on both developmental and external cues, demonstrating the importance of AtSDR4L in seedling establishment under suboptimal conditions.
Assembly dynamics of East Asian subtropical evergreen broadleaved forests: New insights from the dominant Fagaceae trees
Authors: Hai Lisi , Li Xiao‐Qian , Zhang Jing‐Bo , Xiang Xiao‐Guo , Li Rui‐Qi , Jabbour Florian , Ortiz Rosa del C. , Lu An‐Ming , Chen Zhi‐Duan , Wang Wei 
Published: September 2022

ABSTRACTThe dominant species of a biome can be regarded as its genuine indicator. Evergreen broadleaved forests (EBLFs) in subtropical East Asia harbor high levels of species biodiversity and endemism and are vital to regional carbon storage and cycling. However, the historical assembly of this unique biome is still controversial. Fagaceae is the most essential family in East Asian subtropical EBLFs and its dominant species are vital for the existence of this biome. Here, we used the dominant Fagaceae species to shed light on the dynamic process of East Asian subtropical EBLFs over time. Our results indicate high precipitation in summer and low temperature in winter are the most influential climatic factors for the distribution of East Asian subtropical EBLFs. Modern East Asian subtropical EBLFs did not begin to appear until 23 Ma, subsequently experienced a long‐lasting development in the Miocene and markedly deteriorated at about 4 Ma, driven jointly by orogenesis and paleoclimate. We also document that there is a lag time between when one clade invaded the region and when its members become dominant species within the region. This study may improve our ability to predict and mitigate the threats to biodiversity of East Asian subtropical EBLFs and points to a new path for future studies involving multidisciplinary methods to explore the assembly of regional biomes.
Specific detection and deletion of the sigma‐1 receptor widely expressed in neurons and glial cells in vivo
Authors: Liu Qing , Guo Qilin , Fang Li‐Pao , Yao Honghong , Scheller Anja , Kirchhoff Frank , Huang Wenhui 
Published: September 2022

AbstractThe chaperon protein sigma‐1 receptor (S1R) has been discovered over 40 years ago. Recent pharmacological studies using S1R exogenous ligands demonstrated a promising therapeutical potential of targeting the S1R in several neurological disorders. Although intensive in vitro studies have revealed S1Rs are mainly residing at the membrane of the endoplasmic reticulum (ER), the cell‐specific in vivo expression pattern of S1Rs is still unclear, mainly because of the lack of a reliable detection method which also prevented a comprehensive functional analysis. Here, first, we identified a highly specific antibody using S1R knockout (KO) mice and established an immunohistochemical protocol involving a 1% sodium dodecyl sulphate (SDS) antigen retrieval step. Second, we characterized the S1R expression in the mouse brain and can demonstrate that the S1R is widely expressed: in principal neurons, interneurons and all glial cell types. In addition, unlike reported in previous studies, we showed that the S1R expression in astrocytes is not colocalized with the astrocytic cytoskeleton protein GFAP. Thus, our results raise concerns over previously reported S1R properties. Finally, we generated a Cre‐dependent S1R conditional KO mouse (S1R flox) to study cell‐type‐specific functions of the S1R. As a proof of concept, we successfully ablated S1R expressions in neurons or microglia employing neuronal and microglial Cre‐expressing mice, respectively. In summary, we provide powerful tools to cell‐specifically detect, delete and functionally characterize S1R in vivo.image
Role of interaction for caller satisfaction in telenursing—A cross‐sectional survey study
Authors: Mattisson Marie , Börjeson Sussanne , Årestedt Kristofer , Lindberg Malou 
Published: September 2022

AbstractAims and objectivesThe aim of this study was to explore caller satisfaction with interaction, and the association to overall satisfaction with calls.BackgroundIn the era of expanding healthcare at distance, the telephone remains a common tool for the provision of nursing care. Interaction between telenurse and caller in telenursing is vital for safety, satisfaction and adherence reasons. Few studies have quantitatively explored interaction in calls and how it relates to overall satisfaction with calls.DesignCross‐sectional survey study with a deductive approach.MethodsA total of 466 callers to the Swedish Medical Advisory Service completed the Telenursing Interaction and Satisfaction Questionnaire. Satisfaction with four theoretically defined components of interaction were compared using repeated measures ANOVA. Associations between satisfaction with interaction and overall satisfaction with calls were evaluated with ordinal logistic regression models with and without adjustment for age, sex, health status, waiting time, time for call, main result of the call and expectations. The study followed the STROBE checklist.ResultsCallers were most satisfied with affective support, followed by professional‐technical competence, health information and decisional control—in that order. A summated score of satisfaction with interaction was positively and significantly associated with overall satisfaction with calls before and after adjustment for waiting time, main result of call and variables related to the individual caller.ConclusionsCaller satisfaction with interaction is generally high but can be improved, especially regarding decisional control. Satisfaction with interaction is important for overall satisfaction with calls.Relevance to clinical practiceThis study provides support for professionals at all levels in telenursing organisations to pay attention to interactional matters. The development of best practice for telenurses needs to consider all four components of interaction to enhance satisfaction with calls.
Hsa‐miR‐3202 attenuates Jurkat cell infiltration via MMP2 in primary Sjögren's syndrome
Authors: Gao Qi , Ye Zhuang , Liu Tao , Jiang Jing , Jiang Zhenyu , Cao Donghui , Zhao Ling 
Published: September 2022

AbstractBackgroundPrimary Sjögren's syndrome is characterized by lymphocytic infiltration and dysfunction of exocrine glands. The persistent presence of lymphocytes in these glands is an important cause of injury to glandular epithelial cells. MicroRNAs play an important role in primary Sjögren's syndrome and regulate mRNA expression. This study evaluated the expression of microRNA related to lymphocyte infiltration in primary Sjögren's syndrome patients so as to find novel diagnostic and therapeutic targets for primary Sjögren's syndrome. We also explored the microRNA–mRNA networks related to lymphocyte infiltration.MethodsmRNA‐seq and microRNA‐seq of peripheral blood mononuclear cells (PBMCs) were performed on samples from five primary Sjögren's syndrome patients and five matched healthy controls. Meanwhile, microRNA–mRNA network analysis was also conducted. RT‐qPCR was used for validation of differentially expressed RNAs. Immunohistochemistry analysis was used to detect MMP2 expression in labial gland tissue. Hsa‐miR‐3202 mimics/inhibitor‐transfected Jurkat cells were used to measure the effects of hsa‐miR‐3202 on the infiltration potential of T cells.ResultsmRNA and microRNA sequencing revealed that 84 differentially expressed mRNAs and 49 differentially expressed microRNAs had a mutual regulatory relationship. Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis indicated that differentially expressed MMP2 and its related microRNA, hsa‐miR‐3202, were enriched in the leukocyte transendothelial migration pathway. MMP2 was highly expressed in PBMC and labial gland tissue in primary Sjögren's syndrome patients. Hsa‐miR‐3202 was lower expressed in primary Sjögren's syndrome than healthy control. Furthermore, hsa‐miR‐3202 mimics transfection decreased MMP2 expression in Jurkat cells, and inhibited Jurkat cells invasion (p = 0.047).ConclusionLarge number of differentially expressed microRNAs and mRNAs were detected in primary Sjögren's syndrome, and these differentially expressed microRNAs and mRNAs had a mutual regulatory relationship and played an important role in primary Sjögren's syndrome. In the study, we found hsa‐miR‐3202 regulate MMP2 and inhibited the infiltration of T cells from peripheral blood into the gland, which played a protective role.
Deep learning‐based automatic detection of muck types for earth pressure balance shield tunneling in soft ground
Authors: Zhang Dongming , Fu Lei , Huang Hongwei , Wu Huiming , Li Gang 
Published: September 2022

AbstractFor the earth pressure balance shield, the muck can reflect soil information at the tunnel face to track the change in geologic conditions. Thus, this paper presents a general framework for automatic detection of muck types based on the on‐site surveillance camera using deep learning algorithms. A simplified muck classification method and the corresponding muck recognition criteria are proposed for the muck detection task. The muck detection model (MDM) based on You Only Look Once v4, is established on the muck dataset for Shanghai (MSH) after some optimization treatments. The mean average precision value of 97.73% of MDM is twice that of the original model of 48.47%. The MDM is then applied to Metro Line 14 in Shanghai. Results show that The MDM performs well and meets the real‐time requirements with frames per second of 60, and it outperforms other state‐of‐the‐art detection models both in accuracy and speed.
Tired of climate targets? Shift focus of IPCC scenarios from emission and growth targets to policies
Authors: Savin Ivan , van den Bergh Jeroen 
Published: September 2022

AbstractClimate change has revived the debate on growth‐versus‐environment. In line with this, recently it has been proposed to shift the target focus of IPCC scenarios from emissions to post‐growth. We argue here that this confounds ends and means, since while reduction of growth may be an outcome of good climate policies, it should not be a goal in itself. In fact, a post‐ or degrowth goal would mean an ineffective and costly way to reduce emissions. Instead, we suggest that the debate about pursuing economic growth versus achieving climate goals will become more transparent and policy‐relevant through refocusing scenarios from targets to policy.
One‐year Ocular Safety Observation of Workers and Estimations of Microorganism Inactivation Efficacy in the Room Irradiated with 222‐nm Far Ultraviolet‐C Lamps
Authors: Sugihara Kazunobu , Kaidzu Sachiko , Sasaki Masahiro , Ichioka Sho , Takayanagi Yuji , Shimizu Hiroshi , Sano Ichiya , Hara Katsunori , Tanito Masaki 
Published: September 2022

AbstractTwo krypton‐chloride germicidal excimer lamp units (Care222 TRT‐104C11‐UI‐U3, USHIO Inc.) were installed in the examination room of an ophthalmology department. The irradiation dose was set not to exceed the former (i.e., before 2022) threshold limit value (TLV) (22 mJ cm−2/8 h) recommended by the ACGIH. Section 1: The eyes and lids of the six ophthalmologists (5 wore glasses for myopic correction) who worked in the room for a mean stay of 6.7 h week−1 were prospectively observed for 12 months. Slitlamp examinations revealed neither acute adverse events such as corneal erosion, conjunctival hyperemia, and lid skin erythema nor chronic adverse events such as pterygium, cataract, or lid tumor. The visual acuity, refractive error, and corneal endothelial cell density remained unchanged during the study. Section 2: The irradiation of samples placed on the table or floor using the same fixtures in the room (5–7.5 mJ cm−2) was associated with >99% inhibition of φX174 phage and >90% inhibition of Staphylococcus aureus. In conclusion, no acute or chronic health effects in human participants was observed in a clinical setting of full‐room ultraviolet germicidal irradiation by 222‐nm lamp units, and high efficacy in deactivation of microorganisms was determined in the same setting.
Calcium chelate is as effective as phosphite in controlling Phytophthora root rot in glasshouse trials
Authors: Khdiar Mohammed Y. , Burgess Treena I. , Barber Paul A. , Hardy Giles E. St.J. 
Published: September 2022

AbstractSpecies in the genus Phytophthora cause significant economic losses in crops and damage to forests and natural ecosystems worldwide. Currently, phosphite is the most effective chemical for disease management, but excessive phosphite concentrations can result in phytotoxicity in plants and the development of tolerance by the pathogen. Two newly developed metal chelates and phosphite (alone and in combination) were tested for their in vitro and in planta efficacy against Phytophthora cinnamomi. In glasshouse trials, 0.25% and 0.5% of each chemical treatment (phosphite, Ca chelate, Zn chelate) and Ca chelate + phosphite were used as a foliar application on 3‐month‐old seedlings of Banksia grandis (experiment not repeated) and Eucalyptus marginata, prior to inoculation with P. cinnamomi. All noninoculated control plants remained healthy, while significant root damage and reduction of dry root weights were observed for inoculated untreated plants. Individually, phosphite and Ca chelate significantly reduced root lesion development of P. cinnamomi compared to the control, with Ca chelate attaining superior results to phosphite at the same concentration. In combination, Ca chelate + phosphite had the largest reduction in root lesion development in both plant species; however, this result has not yet been replicated but did reflect previous in vitro results. The Zn chelate applications were not effective. Ca chelate has the potential to be developed as a fungicide to control Phytophthora species.
Association between frequency of going out and mild cognitive impairment in community‐dwelling older adults: a pilot study in frailty prevention groups
Authors: Minaki Kazuma , Amano Hiroki , Masumoto Toshio , Otani Shinji , Urakami Katsuya , Kurozawa Youichi 
Published: September 2022

AbstractBackgroundClarifying the role of physical limitations in the relationship between frequency of going out and mild cognitive impairment (MCI) may be useful in supporting early detection and prevention of MCI. However, few studies have explored relatively active populations that are continuously active throughout the year. This study aimed to determine the relationship between frequency of going out and MCI among non‐homebound older adults who participated in group activities to prevent frailty.MethodsThis prospective cohort study used frequency of going out as the exposure and MCI as the outcome. The Touch Panel‐type Dementia Assessment Scale and questionnaires about daily life were completed by 153 community‐dwelling older adults aged ≥65 years participating in frailty prevention groups in a rural town. The baseline survey was conducted from December 2017 to March 2018 and analysed cross‐sectionally. Follow‐up surveys were conducted at 1‐ and 2‐years and analysed longitudinally.ResultsUnivariate and binomial logistic regression analyses at baseline showed no association between MCI and frequency of going out in older adults with physical limitations. However, there was a significant association in older adults without physical limitations. A binomial logistic regression analysis of the frequency of going out at baseline and cognitive function at the 2‐year follow‐up showed no association between MCI and frequency of going out in older adults with physical limitations, but there was a significant association in those without physical limitations.ConclusionOur results suggest that frequency of going out may not be a useful indicator of MCI in older adults with physical limitations, although low frequency of going out may be an indicator of MCI in older adults without physical limitations.
Review of waste phosphorus from aquaculture: Source, removal and recovery
Authors: Luo Guozhi 
Published: September 2022

AbstractThe contribution of phosphorus to water body eutrophication is a global environmental problem, and rapid increases in aquaculture are considered a significant source of phosphorus discharged into the environment. The current review focuses on the source of aquaculture waste phosphorus and measures to decrease phosphorus release into the environment. Because diets are a significant source of phosphorus in fed aquaculture systems, improving the utilization efficiency of dietary phosphorus can reduce the amount of waste phosphorus at the source. A wide range of removal and recovery technologies has been identified, including adsorption, crystallization, enhanced biological phosphorus removal (EBPR), denitrifying phosphorus removal, heterotrophic nitrification aerobic denitrification (HAND) and photosynthetic organism removal. Recovery technologies were also reviewed, particularly sludge phosphorus from recirculating aquaculture systems. A new method using bacteria to immobilize waste nitrogen and phosphorus into bioflocs has been proposed as a better solution. However, most of these technologies have only been implemented at the lab scale to pilot scale. Further studies are necessary to determine the working conditions and removal capacities of related technologies on a commercial scale. Moreover, phosphorus removal methods must be selected based on a consideration of recyclability.