bluuebunny/crossref_metadata_2025_split huggingface dataset:
Vagus activation by Cold Face Test reduces acute psychosocial stress responses
Authors: Richer Robert , Zenkner Janis , Küderle Arne , Rohleder Nicolas , Eskofier Bjoern M. 
Published: November 2022

AbstractChronic stress is linked to dysregulations of the two major stress pathways—the sympathetic nervous system and the hypothalamic-pituitary-adrenal (HPA) axis, which could for example result from maladaptive responses to repeated acute stress. Improving recovery from acute stress could therefore help to prevent this dysregulation. One possibility of physiologically interfering with an acute stress reaction might be provided by applying a cold stimulus to the face (Cold Face Test, CFT) which activates the parasympathetic nervous system (PNS), leading to immediate heart rate decreases. Therefore, we investigated the use of the CFT protocol as an intervention to reduce acute stress responses. Twenty-eight healthy participants were exposed to acute psychosocial stress via the Montreal Imaging Stress Task (MIST) in a randomized between-subjects design while heart rate (HR), heart rate variability (HRV), and salivary cortisol were assessed. While both groups were equally stressed during the procedure, participants with CFT intervention showed better recovery, indicated by significant ($$p<0.05$$

p
<
0.05

) differences in HR(V). We additionally found a significantly ($$p<0.05$$

p
<
0.05

) lower cortisol response to the MIST and less overall cortisol secretion in the CFT condition. Both findings indicate that the CFT can successfully stimulate the PNS and inhibit the HPA axis. To the best of our knowledge, our experiment is the first to successfully use the CFT as a simple and easy-to-apply method to modify biological responses to acute stress.
Radiographical characteristics and traction duration of impacted maxillary canine requiring surgical exposure and orthodontic traction: a cross-sectional study
Authors: Yang Jin-Seob , Cha Jung-Yul , Lee Ji-Yeon , Choi Sung-Hwan 
Published: November 2022

AbstractThis cross-sectional study aimed to classify the radiographical characteristics of impacted maxillary canines that were surgically exposed following orthodontic traction and to find out which factor is most closely related to traction duration. This study enrolled 74 patients with 87 maxillary canines. Cone-beam computed tomography images, panoramic radiographs, and medical records were analyzed. Cystic-appearing lesion and resorption of adjacent roots were observed in 26.4% and 23.0% of cases, respectively. Impacted maxillary canines were mostly distributed in the lateral incisor area. The mean (± standard deviation) traction duration for the 47 teeth that met the study criteria was 13.9 (± 8.9) months. Impacted maxillary canines treated with surgical exposure and orthodontic traction showed increasing possibilities of palatal impaction and resorption of the adjacent root as they were located mesially (p < 0.05). The distance from the occlusal plane to the impacted maxillary canine showed the strongest positive correlation with traction duration (r = 0.519, p < 0.01). When establishing treatment plans for patients with impacted maxillary canines, distance from the occlusal plane to the impacted canines, rather than the angle, should be considered in predicting the duration of treatment.
Lactate-mediated neural plasticity genes emerged during the evolution of memory systems
Authors: Bajaffer Amal , Mineta Katsuhiko , Magistretti Pierre , Gojobori Takashi 
Published: November 2022

AbstractThe ability to record experiences and learning is present to different degrees in several species; however, the complexity and diversity of memory processes are cognitive function features that differentiate humans from other species. Lactate has recently been discovered to act as a signaling molecule for neuronal plasticity linked to long-term memory. Because lactate is not only an energy substrate for neurons but also a signaling molecule for plasticity (Magistretti and Allaman in Nat Rev Neurosci 19:235–249, 2018. https://doi.org/10.1038/nrn.2018.19), it is of particular interest to understand how and when memory-related genes and lactate-mediated neural plasticity (LMNP) genes emerged and evolved in humans. To understand the evolutionary origin and processes of memory and LMNP genes, we first collected information on genes related to memory and LMNP from the literature and then conducted a comparative analysis of these genes. We found that the memory and LMNP genes have different origins, suggesting that these genes may have become established gradually in evolutionarily and functional terms and not at the same time. We also found that memory and LMNP systems have a similar evolutionary history, having been formed with the gradual participation of newly emerging genes throughout their evolution. We propose that the function of LMNP as a signaling process may be evolutionarily associated with memory systems through an unidentified system that is linked by 13 common genes between memory and LMNP gene sets. This study provides evolutionary insight into the possible relationship between memory and the LMNP systems that deepens our understanding of the evolution of memory systems.
Five years’ experience of the clinical exome sequencing in a Spanish single center
Authors: Arteche-López A. , Ávila-Fernández A. , Riveiro Álvarez R. , Almoguera B. , Bustamante Aragonés A. , Martin-Merida I. , López Martínez M. A. , Giménez Pardo A. , Vélez-Monsalve C. , Gallego Merlo J. , García Vara I. , Blanco-Kelly F. , Tahsin Swafiri S. , Lorda Sánchez I. , Trujillo Tiebas M. J. , Ayuso C. 
Published: November 2022

AbstractNowadays, exome sequencing is a robust and cost-efficient genetic diagnostic tool already implemented in many clinical laboratories. Despite it has undoubtedly improved our diagnostic capacity and has allowed the discovery of many new Mendelian-disease genes, it only provides a molecular diagnosis in up to 25–30% of cases. Here, we comprehensively evaluate the results of a large sample set of 4974 clinical exomes performed in our laboratory over a period of 5 years, showing a global diagnostic rate of 24.62% (1391/4974). For the evaluation we establish different groups of diseases and demonstrate how the diagnostic rate is not only dependent on the analyzed group of diseases (43.12% in ophthalmological cases vs 16.61% in neurological cases) but on the specific disorder (47.49% in retinal dystrophies vs 24.02% in optic atrophy; 18.88% in neuropathies/paraparesias vs 11.43% in dementias). We also detail the most frequent mutated genes within each group of disorders and discuss, on our experience, further investigations and directions needed for the benefit of patients.
β-caryophyllene and docosahexaenoic acid, isolated or associated, have potential antinociceptive and anti-inflammatory effects in vitro and in vivo
Authors: Sousa Laís Ferraz Brito , Oliveira Hellen Braga Martins , das Neves Selis Nathan , Morbeck Lorena Lobo Brito , Santos Talita Costa , da Silva Lucas Santana Coelho , Viana Jully Chayra Santos , Reis Mariane Mares , Sampaio Beatriz Almeida , Campos Guilherme Barreto , Timenetsky Jorge , Yatsuda Regiane , Marques Lucas Miranda 
Published: November 2022

AbstractInflammation is a complex biological response involving the immune, autonomic, vascular, and somatosensory systems that occurs through the synthesis of inflammatory mediators and pain induction by the activation of nociceptors. Staphylococcus aureus, the main cause of bacteremia, is one of the most common and potent causes of inflammation in public health, with worse clinical outcomes in hospitals. Antioxidant substances have been evaluated as alternative therapeutic analgesics, antioxidants, anti-inflammatory agents, antitumor agents, and bactericides. Among these, we highlight the essential oils of aromatic plants, such as β-caryophyllene (BCP), and polyunsaturated fatty acids, such as docosahexaenoic acid (DHA). The objective of this study was to evaluate the biological activities of BCP–DHA association in in vitro and in vivo experimental models of antinociception and inflammation. To determine the anti-inflammatory effects, monocytes isolated from the peripheral blood of adult male volunteers were infected with methicillin-resistant S. aureus and incubated with treatment for cytokine dosage and gene expression analysis. Antinociceptive effects were observed in the three models when comparing the control (saline) and the BCP-DHA treatment groups. For this purpose, the antinociceptive effects were evaluated in animal models using the following tests: acetic acid-induced abdominal writhing, paw edema induced by formalin intraplantar injection, and von Frey hypernociception. There was a significant reduction in the GM-CSF, TNFα, IL-1, IL-6, and IL-12 levels and an increase in IL-10 levels in the BCP-DHA treatment groups, in addition to negative regulation of the expression of the genes involved in the intracellular inflammatory signaling cascade (IL-2, IL-6, IRF7, NLRP3, and TYK2) in all groups receiving treatment, regardless of the presence of infection. Statistically significant results (p < 0.05) were obtained in the acetic acid-induced abdominal writhing test, evaluation of paw edema, evaluation of paw flinching and licking in the formalin intraplantar injection model, and the von Frey hypernociception test. Therefore, BCP and DHA, either administered individually or combined, demonstrate potent anti-inflammatory and antinociceptive effects.
SimTune: bridging the simulator reality gap for resource management in edge-cloud computing
Authors: Tuli Shreshth , Casale Giuliano , Jennings Nicholas R. 
Published: November 2022

AbstractIndustries and services are undergoing an Internet of Things centric transformation globally, giving rise to an explosion of multi-modal data generated each second. This, with the requirement of low-latency result delivery, has led to the ubiquitous adoption of edge and cloud computing paradigms. Edge computing follows the data gravity principle, wherein the computational devices move closer to the end-users to minimize data transfer and communication times. However, large-scale computation has exacerbated the problem of efficient resource management in hybrid edge-cloud platforms. In this regard, data-driven models such as deep neural networks (DNNs) have gained popularity to give rise to the notion of edge intelligence. However, DNNs face significant problems of data saturation when fed volatile data. Data saturation is when providing more data does not translate to improvements in performance. To address this issue, prior work has leveraged coupled simulators that, akin to digital twins, generate out-of-distribution training data alleviating the data-saturation problem. However, simulators face the reality-gap problem, which is the inaccuracy in the emulation of real computational infrastructure due to the abstractions in such simulators. To combat this, we develop a framework, SimTune, that tackles this challenge by leveraging a low-fidelity surrogate model of the high-fidelity simulator to update the parameters of the latter, so to increase the simulation accuracy. This further helps co-simulated methods to generalize to edge-cloud configurations for which human encoded parameters are not known apriori. Experiments comparing SimTune against state-of-the-art data-driven resource management solutions on a real edge-cloud platform demonstrate that simulator tuning can improve quality of service metrics such as energy consumption and response time by up to 14.7% and 7.6% respectively.
Conjugate heat transfer study of various cooling structures and sensitivity analysis of overall cooling effectiveness
Authors: Liu Runzhou , Li Haiwang , You Ruquan , Huang Yi , Tao Zhi 
Published: November 2022

AbstractThe conjugate heat transfer of a turbine blade is influenced by several factors. To analyze the influence of each factor, the published one-dimensional conjugate heat transfer model was improved through theoretical analysis in this study. An overall cooling effectiveness equation containing three dimensionless parameters (adiabatic film cooling effectivenessη, Biot number on the mainstream sideBig, and ratio between the heat transfer coefficients of the external and internal wallshg/hi) was obtained. The sensitivity of the overall cooling effectivenessϕto these three parameters was obtained through a multi-parameter sensitivity analysis. The results showed that increasingηcould improveϕthe most effectively. The interactions between the dimensionless parameters were analyzed by developing sensitivity charts. The results showed that increasingηfrom 0.4 to 0.5 could reduce the sensitivity ofϕto the other two parameters by approximately 15%, whereas increasingBighad little effect on the sensitivity ofϕto each dimensionless parameter. Increasinghg/hicould improve the sensitivity toη. The above conclusions could also be applied to the plate film hole and plate impingement effusion structures. The effects of different internal cooling structures and film hole structures on the three dimensionless parameters were studied by performing numerical simulations, which verified the accuracy of the one-dimensional conjugate heat transfer model in this study. The results showed that the internal cooling structures had little effect on the distribution ofηandBig. The heat transfer coefficient on the coolant side could be effectively improved by installing film holes. The film hole structures mainly affectedϕby influencing the distribution ofη.
Improving pediatric idiopathic intracranial hypertension care: a retrospective cohort study
Authors: Nitzan–Luques Adi , Bulkowstein Yarden , Barnoy Noa , Aran Adi , Reif Shimon , Gilboa Tal 
Published: November 2022

AbstractTo describe the clinical course and prognosis of pediatric idiopathic intracranial hypertension (IIH) and examine the preferred management setting.
IIH is characterized by increased intracranial pressure and is often associated with headaches and visual complaints. IIH is a preventable cause of vision loss in children. Hence, a rapid diagnosis followed by prompt treatment and follow-up is essential. However, standardization of the management of IIH in the pediatric population is not well established. Computerized medical charts of all 82 pediatric (< 18 years) patients diagnosed with IIH between 2007 and 2018 in the metropolitan area of Jerusalem were reviewed. Comparison was made between children followed in a multidisciplinary clinic in tertiary centers and those followed elsewhere. Detailed demographic and clinical data, as well as data regarding the follow-up setting and clinical course of the disease, were collected and analyzed. Recurrent IIH-related hospital returns were selected as a measurable marker for the uncontrolled disease. Recurrent IIH-related hospital return rate was significantly lower and occurred later among children followed by multidisciplinary teams compared to individual experts. Follow-up in multidisciplinary clinics improve the quality of life, and financial burden and may prevent permanent visual impairment in children with IIH.
Plant-frugivore network simplification under habitat fragmentation leaves a small core of interacting generalists
Authors: Li Wande , Zhu Chen , Grass Ingo , Vázquez Diego P. , Wang Duorun , Zhao Yuhao , Zeng Di , Kang Yi , Ding Ping , Si Xingfeng 
Published: November 2022

AbstractHabitat fragmentation impacts seed dispersal processes that are important in maintaining biodiversity and ecosystem functioning. However, it is still unclear how habitat fragmentation affects frugivorous interactions due to the lack of high-quality data on plant-frugivore networks. Here we recorded 10,117 plant-frugivore interactions from 22 reservoir islands and six nearby mainland sites using the technology of arboreal camera trapping to assess the effects of island area and isolation on the diversity, structure, and stability of plant-frugivore networks. We found that network simplification under habitat fragmentation reduces the number of interactions involving specialized species and large-bodied frugivores. Small islands had more connected, less modular, and more nested networks that consisted mainly of small-bodied birds and abundant plants, as well as showed evidence of interaction release (i.e., dietary expansion of frugivores). Our results reveal the importance of preserving large forest remnants to support plant-frugivore interaction diversity and forest functionality.
Qubits based on merons in magnetic nanodisks
Authors: Xia Jing , Zhang Xichao , Liu Xiaoxi , Zhou Yan , Ezawa Motohiko 
Published: November 2022

AbstractA meron is a classical topological soliton having a half topological charge. It could be materialized in a magnetic disk. However, it will become a quantum mechanical object when its size is of the order of nanometers. Here, we propose to use a nanoscale meron in a magnetic nanodisk as a qubit, where the up and down directions of the core spin are assigned to be the qubit states $$\left\vert 0\right\rangle$$

0

and $$\left\vert 1\right\rangle$$

1

. We first numerically show that a meron with the radius containing as small as 7 spins can be stabilized in a ferromagnetic nanodisk classically. Then, we show theoretically that universal quantum computation is possible based on merons by explicitly constructing the arbitrary phase-shift gate, Hadamard gate, and CNOT gate. They are executed by applying a magnetic field or spin-polarized current. Our results may be useful for the implementation of quantum computation based on topological spin textures in nanomagnets.
Microbiome diversity and metabolic capacity determines the trophic ecology of the holobiont in Caribbean sponges
Authors: Lesser Michael P , Pankey M Sabrina , Slattery Marc , Macartney Keir J , Gochfeld Deborah J 
Published: November 2022

Abstract
Sponges are increasingly recognized as an ecologically important taxon on coral reefs, representing significant biomass and biodiversity where sponges have replaced scleractinian corals. Most sponge species can be divided into two symbiotic states based on symbiont community structure and abundance (i.e., the microbiome), and are characterized as high microbial abundance (HMA) or low microbial abundance (LMA) sponges. Across the Caribbean, sponge species of the HMA or LMA symbiotic states differ in metabolic capacity, as well as their trophic ecology. A metagenetic analysis of symbiont 16 S rRNA and metagenomes showed that HMA sponge microbiomes are more functionally diverse than LMA microbiomes, offer greater metabolic functional capacity and redundancy, and encode for the biosynthesis of secondary metabolites. Stable isotope analyses showed that HMA and LMA sponges primarily consume dissolved organic matter (DOM) derived from external autotrophic sources, or live particulate organic matter (POM) in the form of bacterioplankton, respectively, resulting in a low degree of resource competition between these symbiont states. As many coral reefs have undergone phase shifts from coral- to macroalgal-dominated reefs, the role of DOM, and the potential for future declines in POM due to decreased picoplankton productivity, may result in an increased abundance of chemically defended HMA sponges on tropical coral reefs.
Gute Blutdruckeinstellung hemmt Progression der chronischen Niereninsuffizienz (CKD)
Authors: Obermüller Nicholas 
Published: November 2022

ZUSAMMENFASSUNGDie chronische Niereninsuffizienz (CKD) ist eine häufig erst in späteren Stadien erkannte Erkrankung, deren weltweite Inzidenz tendenziell ansteigt. Einerseits bedingen kardiovaskuläre Erkrankungen eine CKD, andererseits häufen sich durch einen fortschreitenden Nierenfunktionsverlust diverse kardiovaskuläre Ereignisse. Die Primärursache einer Niereninsuffizienz sollte möglichst immer kausal behandelt werden. Dies ist jedoch häufig nur partiell möglich, wenn glomerulär-tubuläre Schäden bereits vorhanden sind und der meistens schon früh bestehende (renale) Bluthochdruck die Nierenfunktion auch unabhängig von der Primärursache verschlechtert. Daher sollte der (renale) Blutdruck gut eingestellt werden, da allein dadurch die CKD-Progression verlangsamt werden kann. Hemmer des Renin-Angiotensin-Aldosteron-Systems haben sich als vorteilhafte Substanzen etabliert, da sie Systemdruck und intrarenalen Druck, aber auch die Proteinurie günstig beeinflussen. Das bedeutet, „gute“ Blutdrucksenkung“ verringert auch den glomerulären „Blutdruck“ bzw. den Druck im Gefäßsystem der Niere. Was der optimale Zielblutdruck ist, hängt stets vom Risikoprofil ab.
Sinnvolle Diagnose und Therapie von hormonabhängigen Hypertonusformen
Authors: Schmidt Sebastian , Kloos Christof , Busch Martin , Wolf Gunter 
Published: November 2022

ZUSAMMENFASSUNGSekundäre Hypertonieformen entstehen überwiegend durch renovaskuläre, renoparenchymatöse und endokrine Ursachen. Ein unzureichend eingestellter Blutdruck unter mindestens 3 Antihypertensiva unter Einschluss eines Diuretikums sollte auf sekundäre Ursachen abgeklärt werden. Die Diagnostik umfasst Anamnese, klinische Untersuchung, Laborscreening, Bestätigungstests, Bildgebung und ggf. selektiven Venenkatheter. Therapieoptionen sind primär die Operation und/oder medikamentöse Ansätze. Antihypertensiva können postoperativ oft reduziert werden. Nach bilateraler Adrenalektomie ist die lebenslange Hormonsubstitution erforderlich. Die endokrinologische Verlaufskontrolle und Nachsorge postoperativ sollte mindestens jährlich erfolgen. Die Zusammenarbeit zwischen Hausärzten und Ärzten der Inneren Medizin und Chirurgie mit endokriner Expertise ist notwendig. Die wichtigsten endokrinen Erkrankungen primärer Hyperaldosteronismus, Cushing-Syndrom und Paragangliom/Phäochromozytom (PGL/PCC) werden in dieser Übersicht detailliert dargestellt.
Evaluation of the Optic Nerve Head Using Optical Coherence Tomography Angiography in Systemic Sclerosis Patients
Authors: Zirtiloglu Sibel , Alikma Mustafa Suat , Acar Ozge Pinar Akarsu , Güven Fatih , Icacan Ozan Cemal , Yigit Fadime Ulviye 
Published: November 2022

Abstract
Purpose To quantify microvascular vessel density in the optic disc using optical coherence tomography angiography (OCTA) in patients with systemic sclerosis (SS); to determine
whether there is a difference in values between patients and controls; and to correlate the OCTA measurements with disease activity, damage risk, and drug usage.
Methods Patients aged 20 – 76 years who were followed up after a diagnosis of SS and age- and gender-matched controls. The patients underwent RTVue-XR AngioVue OCTA imaging in this
cross-sectional observational study.
Results A total of 61 eyes of 61 consecutive SS patients and 60 eyes of 60 controls were investigated. There was no statistically significant difference between the patients and
control groups regarding the average RNFL (retinal fiber layer) and radial peripapillary capillary (RPC) vessel density (VD) measurements (p = 0.35, p = 0.25, respectively). As the
antinuclear antibody (ANA) titer increased, RNFLsuperior (p = 0.01, r = − 0.327), RPCwhole (p = 0.029, r = 0.279), RPCperipapillary (p = 0.037, r = − 0.267), RPCsuperior (p = 0.003,
r = − 0.371), and RPCinferior (p = 0.02, r = 0.297) values decreased with statistical significance. The RPCinside values were lower in anti-Scl-70-positive patients compared to patients
negative for anti-Scl-70 (topoisomerase I) (p = 0.021). The RNFLnasal (p = 0.03, r = − 0.278) value decreased as the years of disease increased. The RPCinside value was higher in patients
using hydroxychloroquine and calcium channel blockers than those who did not use them (p = 0.021 and p = 0.027, respectively). The RPCwhole, RPCperipapillary, and RPCnasal values were
higher, with statistical significance in corticosteroid users than in those patients who did not use corticosteroids (p = 0.043, 0.030, and 0.033, respectively).
Conclusion There was no significant difference between the patients and control groups regarding the average RPC VD measurements. However, since this is the first study to analyze
optic disc vessel density in SS patients, optic nerve blood flow changes in scleroderma with OCTA could be studied.