bluuebunny/crossref_metadata_2025_split huggingface dataset:
Utilising in situ simulation within translational simulation programmes to evaluate and improve multidisciplinary response to anaphylaxis in the paediatric emergency department
Authors: Price Kim , Cincotta Domenic R , Spencer‐Keefe Felicity R , O'Donnell Sinead M 
Published: November 2022

AbstractObjectiveThe prevalence of paediatric anaphylaxis is rising in Australia. Treatment requires timely administration of intramuscular (IM) adrenaline. Study goals included utilising in situ simulation (ISS) within a translational simulation (TS) programme as a diagnostic tool to identify the frequency and cause of IM adrenaline errors in a paediatric ED, and utilising ISS to evaluate multidisciplinary emergency team response to anaphylaxis.MethodsA prospective observational study was conducted in the Royal Children's Hospital Melbourne ED utilising an ISS anaphylaxis scenario with a debrief pro forma within an established ISS/TS programme.ResultsTwenty‐three anaphylaxis ISS were delivered over 16 months. One hundred and sixty‐four multidisciplinary staff participated (mean of 8 per session). Median times (in minutes) for the total ISS were 12:33 (interquartile range [IQR] 9:06–15:19), consisting of the scenario 4:07 (IQR 3:33–4:44) and debriefing 9:00 (IQR 5–11). IM adrenaline was administered in all ISS within 5 min, median 2:57 (IQR 2:30–3:40). Adrenaline medication errors occurred in 30% ISS (7/23). Errors included three (13%) administrations and four (17%) potential or ‘near misses’ associated with a verbal order or medication preparation error. A weight‐based medication cognitive aid was utilised in 56% (13/23) ISS but was not utilised in all three administration errors.ConclusionsISS within TS programmes was successfully utilised as a diagnostic tool in identifying that medication errors were common during anaphylaxis management in the ED. Improving access to adrenaline in dosing boxes and promoting the utilisation of weight‐based cognitive aids alongside ISS education will likely reduce errors and improve patient safety.
Incidence of traumatic brain injuries in head‐injured children with seizures
Authors: Borland Meredith L , Dalziel Stuart R , Phillips Natalie , Dalton Sarah , Lyttle Mark D , Bressan Silvia , Oakley Ed , Kochar Amit , Furyk Jeremy , Cheek John A , Neutze Jocelyn , Eapen Nitaa , Hearps Stephen JC , Rausa Vanessa C , Babl Franz E ,   the Paediatric Research in Emergency Departments International Collaborative (PREDICT) group
Published: November 2022

AbstractObjectiveIncidence and short‐term outcomes of clinically important traumatic brain injury (ciTBI) in head‐injured children presenting to ED with post‐traumatic seizure (PTS) is not described in current literature.MethodsPlanned secondary analysis of a prospective observational study undertaken in 10 Australasian Paediatric Research in Emergency Departments International Collaborative (PREDICT) network EDs between 2011 and 2014 of head‐injured children <18 years with and without PTS. Clinical predictors and outcomes were analysed by attributable risk (AR), risk ratios (RR) and 95% confidence interval (CI), including the association with Glasgow Coma Scale (GCS) scores.ResultsOf 20 137 head injuries, 336 (1.7%) had PTS with median age of 4.8 years. Initial GCS was 15 in 268/336 (79.8%, AR −16.1 [95% CI −20.4 to −11.8]), 14 in 24/336 (7.1%, AR 4.4 [95% CI 1.6–7.2]) and ≤13 in 44/336 (13.1%, AR 11.7 [95% CI 8.1–15.3]) in comparison with those without PTS, respectively. The ciTBI rate was 34 (10.1%) with PTS versus 219 (1.1%) without PTS (AR 9.0 [95% CI 5.8–12.2]) with 5/268 (1.9%), 6/24 (25.0%) and 23/44 (52.3%) with GCS 15, 14 and ≤13, respectively. In PTS, rates of admission ≥2 nights (34 [10.1%] AR 9.0 [95% CI 5.8–12.3]), intubation >24 h (9 [2.7%] AR 2.5 [95% CI 0.8–4.2]) and neurosurgery (8 [2.4%] AR 2.0 [95% CI 0.4–3.7]), were higher than those without PTS. Children with PTS and GCS 15 or 14 had no neurosurgery, intubations or death, with two deaths in children with PTS and GCS ≤13.ConclusionsPTS was uncommon in head‐injured children presenting to the ED but associated with an increased risk of ciTBI in those with reduced GCS on arrival.
IFT52 plays an essential role in sensory cilia formation and neuronal sensory function in Drosophila
Authors: Hou Ya‐Nan , Zhang Ying‐Ying , Wang Ya‐Ru , Wu Zhi‐Mao , Luan Yun‐Xia , Wei Qing 
Published: November 2022

AbstractCilia are microtubule‐based, hair‐like organelles involved in sensory function or motility, playing critical roles in many physiological processes such as reproduction, organ development, and sensory perception. In insects, cilia are restricted to certain sensory neurons and sperms, being important for chemical and mechanical sensing, and fertility. Although great progress has been made regarding the mechanism of cilia assembly, the formation of insect cilia remains poorly understand, even in the insect model organism Drosophila. Intraflagellar transport (IFT) is a cilia‐specific complex that traffics protein cargos bidirectionally along the ciliary axoneme and is essential for most cilia. Here we investigated the role of IFT52, a core component of IFT‐B, in cilia/flagellar formation in Drosophila. We show that Drosophila IFT52 is distributed along the sensory neuronal cilia, and is essential for sensory cilia formation. Deletion of Ift52 results in severe defects in cilia‐related sensory behaviors. It should be noted that IFT52 is not detected in spermatocyte cilia or sperm flagella of Drosophila. Accordingly, ift52 mutants can produce sperms with normal motility, supporting a dispensable role of IFT in Drosophila sperm flagella formation. Altogether, IFT52 is a conserved protein essential for sensory cilia formation and sensory neuronal function in insects.
Impact of floodplain and Stage 0 stream restoration on flood attenuation and floodplain exchange during small frequent storms
Authors: Federman Carly E. , Scott Durelle T. , Hester Erich T. 
Published: November 2022

AbstractRiver flooding impacts human life and infrastructure, yet provides habitat and ecosystem services. Traditional flood control (e.g., levees, dams) reduces habitat and ecosystem services, and exacerbates flooding elsewhere. Floodplain restoration (i.e., bankfull floodplain reconnection and Stage 0) can also provide flood management, but has not been sufficiently evaluated for small frequent storms. We used 1D unsteady Hydrologic Engineering Center's River Analysis System to simulate small storms in a 5 km‐long, second‐order generic stream from the Chesapeake Bay watershed, and varied % channel restored (starting at the upstream end), restoration location, restoration bank height (distinguishes bankfull from Stage 0 restoration), and floodplain width/Manning's n. Stream restoration decreased (attenuated) peak flow up to 37% and increased floodplain exchange by up to 46%. Floodplain width and % channel restored had the largest impact on flood attenuation. The incremental effects of new restoration projects on flood attenuation were greatest when little prior restoration had occurred. By contrast, incremental effects on floodplain exchange were greatest in the presence of substantial prior restoration, setting up a tradeoff. A similar tradeoff was revealed between attenuation and exchange for project location, but not bank height or floodplain width. In particular, attenuation and exchange were always greater for Stage 0 than for bankfull floodplain restoration. Stage 0 thus may counteract human impacts such as urbanization.
Predicted uranium and radon concentrations in New Hampshire (USA) groundwater—Using Multi Order Hydrologic Position as predictors
Authors: Moore Richard B. , Belitz Kenneth , Ayotte Joseph , Arnold Terri L. , Hayes Laura , Sharpe Jennifer B. , Starn Jeffrey J. 
Published: November 2022

AbstractTwo radioactive elements, uranium (U) and radon (Rn), which are of potential concern in New Hampshire (NH) groundwater, are investigated. Exceedance probability maps are tools to highlight locations where the concentrations of undesirable substances in the groundwater may be elevated. Two forms of statistical analysis are used to create exceedance probability maps for U and Rn in NH groundwater. The first, Boosted Regression Tree (BRT), was selected for estimating U exceedance values. It computes exceedance values directly using the Bernoulli distribution function. The second method of statistical analysis used for Rn to determine exceedance probabilities is ordinary least squares (OLS) regression. In the process of determining exceedance probabilities for U and Rn, the utility of a new dataset is investigated. That new predictor dataset is the Multi‐Order Hydrologic Position (MOHP) dataset. MOHP raster datasets have been produced nationally for the conterminous United States at a 30‐m resolution. The concept behind MOHP is that, for any given point on the earth's surface, there is the potential for a longer groundwater flow path as one goes deeper beneath the land surface. MOHP predictors were tested in both models. Three MOHP predictors were found useful in the BRT model and two in the OLS model. MOHP data were found useful as predictors along with other site characteristics in predicting U and Rn exceedance probabilities in New Hampshire groundwater.
Comprehensive analysis of clinical and laboratory features of 440 published cases of Sjögren's syndrome and renal tubular acidosis
Authors: Sandhya Pulukool 
Published: November 2022

AbstractAimTo describe the clinical and laboratory features of Sjögren's syndrome (SS) with renal tubular acidosis (RTA) from published literature.MethodsA systematic search of indexed publications in all languages till December 2021 identified cases of SS with RTA (SS‐RTA) and were included if either antibody (anti‐SSA/anti‐SSB) or salivary gland histopathology were positive.ResultsThere were 440 cases of SS‐RTA (63.9% from Asia, 95.5% women). The median (range) age was 37 (6‐78) years. Only 7.7% had a previous diagnosis of SS. Oral or ocular sicca symptoms were present in 63.7%. Positive ocular tests, oral tests, anti‐SSA, anti‐SSB and salivary gland histopathology were reported in 256/331 (77.3%), 123/128 (96%), 382/407 (93.9%), 298/379 (78.6%), and 246/268 (91.8%), respectively. Hypokalemic paralysis (HP) was the presenting feature in 63.6%; 25% had multiple episodes of HP and 8.4% had respiratory paralysis. Type 1, type 2, combined type 1 & 2, and type 4 RTA was seen in 388, 8, 38, and 3 patients, respectively. Proximal dysfunction and RTA complications were infrequently evaluated. Fanconi syndrome, nephrogenic diabetes insipidus, proteinuria, and low estimated glomerular filtration rate were found in 45, 21, 178, and 157, respectively. Nephrocalcinosis, renal stones, and osteomalacia were reported in 92, 79, and 72, respectively. Tubulointerstitial nephritis was found in 142 out of 152 renal biopsies.ConclusionSS‐RTA is an early manifestation of SS characterized by younger age and subclinical sicca symptoms. Although evaluated less frequently, oral sicca signs and salivary gland biopsy have a high positive yield. HP is the most common presentation. RTA is mostly distal; proximal dysfunction and complications were infrequently assessed.
Industry Sensitivity to External Forces and the Information Advantage of Analysts over Managers*
Authors: Ali Ashiq , Amiram Dan , Kalay Alon , Sadka Gil 
Published: November 2022

ABSTRACTThis study examines whether analysts have an industry‐level information advantage over managers when forecasting earnings. While analysts are often viewed as industry experts, prior research fails to document such an advantage. We predict that analysts' industry‐level information advantage is more likely to exist in industries where firm performance is more sensitive to industry‐level external economic forces. We find that for such firms, analysts provide relatively more accurate earnings forecasts compared to managers. Consistent with our predictions, we further find that managers of such firms provide fewer and less precise forecasts and that this association is more pronounced in firms with higher analyst following. Collectively, these findings suggest that analysts have an industry‐level information advantage over managers when forecasting earnings for firms in industries with high sensitivity to external forces, and that industry sensitivity risk is a distinct industry characteristic that affects firm‐level disclosure.
Israel: Political Developments and Data in 2021
Authors: GANEL YOSI 
Published: November 2022

AbstractThe year 2021 can be described in Israeli politics as one of change. After 12 consecutive years in power as Prime Minister, Benjamin Netanyahu left office. After four election campaigns in two years, the ‘Anti‐Netanyahu bloc’ managed to form a minimum winning coalition of 61 Knesset members (one Member of the Knesset did not vote with the coalition). A rotation government was agreed upon, with the post of Prime Minister switching between Naftali Bennet, Yemina (right‐wing party) leader and Yair Lapid, Yesh Atid leader (the largest party in the coalition). Bennet served as Prime Minister first, even though his party only had six seats in the coalition. During 2021, Israel experienced terrorist incidents and a major military operation, as well as severe riots in mixed Jewish–Arab cities. Economic performance improved as the COVID‐19 restrictions were lifted, with economic indicators being better than for other OECD countries.
Cigarette pack size and consumption: a randomized cross‐over trial
Authors: Lee Ilse , Blackwell Anna K. M. , Hobson Alice , Wiggers Danielle , Hammond David , De‐loyde Katie , Pilling Mark A. , Hollands Gareth J. , Munafò Marcus R. , Marteau Theresa M. 
Published: November 2022

AbstractBackground and AimsSmoking fewer cigarettes per day may increase the chances of stopping smoking. Capping the number of cigarettes per pack is a promising policy option, but the causal impact of such a change is unknown. This study aimed to test the hypothesis that lowering cigarette pack sizes from 25 to 20 reduces the number of cigarettes smoked.DesignThis randomized controlled cross‐over trial had two 14‐day intervention periods with an intervening 7‐day period of usual behaviour. Participants purchased their own cigarettes. They were instructed to smoke their usual brand from either one of two sizes of pack in each of two 14‐day intervention periods: (a) 25 cigarettes and (b) 20 cigarettes. Participants were randomized to the order in which they smoked from the two pack sizes (a–b; b–a).SettingCanada.ParticipantsParticipants were adult smokers who smoked from pack sizes of 25, recruited between July 2020 and June 2021. Of 252 randomized, 240 (95%) completed the study and 236 (94%) provided sufficient data for the primary analysis.MeasurementsCigarettes smoked per participant per day.FindingsParticipants smoked fewer cigarettes per day from packs of 20 cigarettes [n = 234, mean = 15.7 standard deviation (SD) = 7.1] than from packs of 25 (n = 235, mean = 16.9, SD = 7.1). After adjusting for pre‐specified covariates (baseline consumption and heaviness of smoking), modelling estimated that participants smoked 1.3 fewer cigarettes per day [95% confidence interval (CI) = −1.7 to −0.9], equivalent to 7.6% fewer (95% CI = −10.1 to −5.2%) from packs of 20 cigarettes.ConclusionsSmoking from packs of 20 compared with 25 cigarettes reduced the number of cigarettes smoked per day.
Speculative Urban Worldmaking: Meeting Financial Violence with a Politics of Collective Care
Authors: Summers Brandi T. , Fields Desiree 
Published: November 2022

AbstractThis article brings Black feminist thought to bear on the urban geography of racialised financial violence. Our analysis focuses on the Moms 4 Housing movement, which began when five Black mothers occupied a vacant, corporate investor‐owned house in West Oakland to protest how real estate speculation is fuelling displacement and homelessness for Black Oakland residents, disrupting care at the scale of the home and community. In taking space through recuperating the house on Magnolia Street, the Moms insist on housing as a site of care central to the survival of Black families and reclaim Oakland as a Black geographic space. In claiming ownership based on relations of care while refusing the institution of private property, we argue the Moms engage in speculative urban worldmaking—a form of collective care and a praxis of providing an alternative present that imagines and advocates for urban futures beyond financialisation's abstract racial violence.
A meta‐analysis of methotrexate polyglutamates in relation to efficacy and toxicity of methotrexate in inflammatory arthritis, colitis and dermatitis
Authors: van de Meeberg Maartje M. , Hebing Renske C. F. , Nurmohamed Michael T. , Fidder Herma H. , Heymans Martijn W. , Bouma Gerd , de Bruin‐Weller Marjolein S. , Tekstra Janneke , van den Bemt Bart , de Jonge Robert , Bulatović Ćalasan Maja 
Published: November 2022

AimsIn immune‐mediated inflammatory diseases (IMIDs), early symptom control is a key therapeutic goal. Methotrexate (MTX) is the first‐line treatment across IMIDs. However, MTX is underutilized and suboptimally dosed, partly due to the inability of making individualized treatment decisions through therapeutic drug monitoring (TDM). To implement TDM in clinical practice, establishing a relationship between drug concentration and disease activity is paramount. In this meta‐analysis, we investigated the relationship between concentrations of MTX polyglutamates (MTX‐PG) in erythrocytes and efficacy as well as toxicity across IMIDs.MethodsStudies analysing MTX‐PG in relation to disease activity and/or toxicity were included for inflammatory arthritis (rheumatoid [RA] and juvenile idiopathic arthritis [JIA]), inflammatory bowel disease (Crohn's and ulcerative colitis) and dermatitis (psoriasis and atopic dermatitis). Meta‐analyses were performed resulting in several summary effect measures: regression coefficient (β), correlation coefficient and mean difference (of MTX‐PG in responders vs. nonresponders) for IMIDs separately and collectively.ResultsTwenty‐five studies were included. In RA and JIA, higher MTX‐PG was significantly associated with lower disease activity at 3 months (β: −0.002; 95% confidence interval [CI]: −0.004 to −0.001) and after 4 months of MTX use (β: −0.003; 95% CI: −0.005 to −0.002). Similarly, higher MTX‐PG correlated with lower disease activity in psoriasis (R: −0.82; 95% CI: −0.976 to −0.102). Higher MTX‐PG was observed in RA, JIA and psoriasis responders (mean difference: 5.2 nmol/L MTX‐PGtotal; P < .01).ConclusionWe showed that higher concentrations of erythrocyte MTX‐PG were associated with lower disease activity in RA, JIA and psoriasis. These findings are an important step towards implementation of TDM for MTX treatment across IMIDs.
Cyanidin as potential anticancer agent targeting various proliferative pathways
Authors: Safdar Muhammad Azhaf , Aslam Rana Muhammad Nabeel , Shakeel Amna , Shiza  , Waqar Mashael , Jmail Abdullah , Mehmood Malik Hassan , Gul Humaira 
Published: November 2022

AbstractA natural compound cyanidin, which is a type of anthocyanin present in pigmented leaves, fruits, and flowers; distributed widely in berries, apples, and oranges possess anticancer activities, thus curing various types of cancer such as breast, liver, lung, prostate, and thyroid cancer. The article provides an insight into the potential of using a single phytochemical, cyanidin to treat various cancer types including breast, liver, lung, prostate, and thyroid cancer. Information about cyanidin and its pharmacological impact on cancer was collected from books, scientific journals, and reports through electronic data search (Web of Science, Scifinder, PubMed, Scopus, Google Scholar, Elsevier, Springer, Wiley, ACS, Science Direct, CNKI as well as Kew Plants of the Word Online) and library. Cyanidin produces its effects against cancer probably by inhibiting (RAS, MAPK) and activating (caspases‐3 and P‐38) innovative molecular pathways. It may cause cell cycle arrest, cell differentiation processes and changes in redox status which trigger the cytotoxic chemotherapeutic effects. However, it also optimizes the chemotherapeutic targets which are cancer cells less responsive to chemotherapy. Cancer is considered the most widely spread disease and cyanidin from natural origin provides an essential role in treatment of cancer by approaching various mechanistic pathways.
Early detection of anastomotic leak with C‐reactive protein increases the chances of anastomotic salvage
Authors: Gozalichvili David , Binquet Christine , Boisson Cyril , Guiraud Adeline , Facy Olivier , Ortega‐Deballon Pablo 
Published: November 2022

AbstractAimAnastomotic leak results in increased morbidity and affects functional and oncological outcomes after colectomy. Measurement of C‐reactive protein (CRP) allows early detection of anastomotic leaks. The aim of this study was to evaluate the benefit to the patient of earlier diagnosis and management of anastomotic leaks, namely avoiding takedown of the anastomosis.MethodPatients with an anastomotic fistula after elective colorectal surgery from 2010 to 2020 were included. Three periods were defined according to progressive adherence to the CRP protocol in our department. A comparison was made between the periods ‘before’ (2010–2013) and ‘after’ (2016–2020) in terms of morbidity, mortality, anastomotic salvage, days spent in hospital within the first postoperative month, timely adjuvant chemotherapy and anastomotic stenosis.ResultsOut of 2655 elective colorectal operations, 171 patients presented with an anastomotic leak and 123 patients were included in the study. In univariate analysis, patients in the ‘after’ group had fewer severe complications (Clavien–Dindo Grade III to IV, 66.7% vs. 56.9; p = 0.017); the difference did not reach significance regarding timely postoperative chemotherapy (p = 0.058) and anastomotic stenosis (p = 0.682). In both, univariate and multivariate analysis, the ‘after’ period increased the chances of preserving the anastomosis (OR = 2.37 [1.08–5.17]) and increased the number of days out of hospital (p = 0.0002).ConclusionA CRP‐based protocol for the screening of anastomotic leaks after colorectal surgery was related to increased anastomotic conservation, a decreased impact and severity of the leak and a shorter length of hospital stay.
Adsorption removal of Brilliant green and Safranin‐O contaminants from water using a hydrogel based on carboxymethyl cellulose and sodium alginate crosslinked by epichlorohydrin
Authors: Khushbu  , Vaid Vasudha , Dagar Nivaydita , Nikhil  , Jindal Rajeev 
Published: November 2022

AbstractThe current study investigates the adsorption properties of a chemically crosslinked hydrogel based on sodium alginate (NaALG) and carboxymethyl cellulose (CMC). The structural characteristics of the investigated hydrogel are described using information from Fourier Transform–infrared spectra, X‐ray diffraction patterns and field emission scanning electron microscopy pictures. The NaALG/epichlorohydrin (ECH)/CMC hydrogel was synthesised under optimised conditions with respect to the swelling percentage. Various reaction parameters were varied to obtain the maximum swelling percentage. The synthesised hydrogel was taken as an adsorbent in the decolorisation of Brilliant green (BG) and Safranin‐O (SO) dyes from water. According to the kinetic investigations, the decolorisation equilibrium of SO by NaALG/ECH/CMC was discovered in 4 hours (98.98%), while the removal of BG by NaALG/ECH/CMC took 6 hours (97.7%). Chemical processes were used to describe the decolorisation mechanisms, which significantly supported the pseudo‐first‐order model. NaALG/ECH/CMC hydrogel absorption was indicated to take place in monolayer adsorption form (Langmuir isotherm). The highest adsorption capacity for BG was discovered to be 864.8 mg g−1 and for SO it was 193.1 mg g−1, by synthesised hydrogel, where “mg” refers to the commercial colourant and not to the pure dye. Therefore, the synthesised hydrogel can be considered as a smart device for the adsorption of dye in water purification tasks.