bluuebunny/crossref_metadata_2025_split huggingface dataset:
Optimal distinctiveness across revenue models: Performance effects of differentiation of paid and free products in a mobile app market
Authors: van Angeren Joey , Vroom Govert , McCann Brian T. , Podoynitsyna Ksenia , Langerak Fred 
Published: March 2022

AbstractResearch SummaryThe optimal distinctiveness literature highlights a fundamental trade‐off in product positioning within market categories: Products should be distinct to minimize competition, but similar to build legitimacy. Most recently, this research has focused on understanding sources of variance in the distinctiveness–performance relationship. We extend this literature with an examination of digital products and argue that the relationship depends on products' revenue models: We theorize the relationship is inverted U‐shaped for paid products but U‐shaped for free products, owing to heightened privacy concerns of free product customers. We further argue that this latter relationship becomes flatter for free products that provide greater monetization transparency by publishing a privacy statement or adopting a freemium revenue approach. Hypotheses are tested using a sample of 250,000‐plus Apple App Store apps.Managerial SummaryHow should firms in the digital space position their products for optimal performance? We study this question in the Apple App Store, and suggest that the optimal positioning of digital products depends on their revenue model. Paid products should be moderately differentiated from competing products. By contrast, free products benefit most from very low or very high levels of differentiation. We attribute the different performance effects of differentiation to customers' privacy concerns over free products. Firms can partially ameliorate those privacy concerns by providing greater monetization transparency by publishing a privacy statement or by adopting a freemium revenue approach, making moderate levels of differentiation more viable. Our findings help managers align choices of positioning and revenue model, two critical aspects of the firm's business model.
Single‐Crystalline Cathodes for Advanced Li‐Ion Batteries: Progress and Challenges
Authors: Han Yongkang , Lei Yike , Ni Jie , Zhang Yingchuan , Geng Zhen , Ming Pingwen , Zhang Cunman , Tian Xiaorui , Shi Ji‐Lei , Guo Yu‐Guo , Xiao Qiangfeng 
Published: March 2022

AbstractSingle‐crystalline cathodes are the most promising candidates for high‐energy‐density lithium‐ion batteries (LIBs). Compared to their polycrystalline counterparts, single‐crystalline cathodes have advantages over liquid‐electrolyte‐based LIBs in terms of cycle life, structural stability, thermal stability, safety, and storage but also have a potential application in solid‐state LIBs. In this review, the development history and recent progress of single‐crystalline cathodes are reviewed, focusing on properties, synthesis, challenges, solutions, and characterization. Synthesis of single‐crystalline cathodes usually involves preparing precursors and subsequent calcination, which are summarized in the details. In the following sections, the development issues of single‐crystalline cathodes, including kinetic limitations, interfacial side reactions, safety issues, reversible planar gliding and micro‐cracking, and particle size distribution and agglomeration, are systematically analyzed, followed by current solutions and characterization techniques. Finally, this review is concluded with proposed research thrusts for the future development of single‐crystalline cathodes.
3D Bioprinted GelMA‐Nanoclay Hydrogels Induce Colorectal Cancer Stem Cells Through Activating Wnt/β‐Catenin Signaling
Authors: Zhang Yanmei , Wang Zixuan , Hu Qifan , Luo Hao , Lu Bingchuan , Gao Yunhe , Qiao Zhi , Zhou Yongsen , Fang Yongcong , Gu Jin , Zhang Ting , Xiong Zhuo 
Published: March 2022

AbstractCancer stem cells (CSCs) are a rare cell population in tumors that are responsible for tumor recurrence and metastasis. They are a priority as therapeutic targets, however, assays targeting CSCs have been limited by expanding and maintaining CSCs in vitro. Here, the authors find that gelatin methacryloyl (GelMA)‐nanoclay hybrid hydrogels can induce and enrich colorectal CSCs assisted by three‐dimensional (3D) bioprinting. The presence of the nanoclay increases the printability, Young's modulus, pore size, and cytocompatibility of the hydrogels. Bioprinted GelMA‐nanoclay hydrogels promote the formation of spheroids expressing elevated levels of the stemness markers LGR5, CD133, CD26, and SOX2. Cancer cells grown in GelMA‐nanoclay hydrogel possess higher self‐renewal and differentiation capacity in vitro and higher tumorigenic capacity in vivo. GelMA‐nanoclay hydrogels induce CSCs by stimulating the activation of the Wnt/β‐catenin signaling pathway. Further studies demonstrate that spheroids from GelMA‐nanoclay hydrogels possess increased stemness, higher consistency, yield, and sensitivity to the anti‐CSC compounds compared to the classic CSC‐enrichment model. Collectively, this study may provide a valuable biomaterial and method for inducing and enriching CSCs, to facilitate the effective CSC‐targeting drug screening.
Financial lessons for student services at community colleges and regional public institutions
Authors: Trentacoste Peter J. , Ward Molly C. , Aluso Salome , Copeland Olivia C. , Nguyen David J. 
Published: March 2022

AbstractThis article reflects on how financial operations, especially at community colleges and regional public institutions, were adversely affected by the pandemic and considers what institutions could do moving forward and for the future.
A perspective on high‐entropy two‐dimensional materials
Authors: Cui Yanglansen , Zhang Yongzheng , Cao Zhenjiang , Gu Jianan , Du Zhiguo , Li Bin , Yang Shubin 
Published: March 2022

AbstractIn past decades, high‐entropy (HE) materials, containing five or more elements with approximately equal atomic ratio, are extensively investigated due to their desirable properties in a series of applications. Recently, HE two‐dimensional (2D) materials have become promising materials, which not only endow the advantages from their bulk form but also exhibit unusual properties due to their 2D features. So far, the HE 2D transition metal carbides (MXenes), dichalcogenides (TMDs), hydrotalcites (LDHs), and oxides have been successfully synthesized and performed well in different electrochemical reactions, which is originated from the synergistic effect of multicomponents and atomic thin characteristics. Here, the challenges on processing, characterization, and property predictions of HE 2D materials are emphasized. Finally, viable strategies, advanced processing, fundamental understanding, in‐depth characterization of new HE 2D materials are proposed.
Exome sequencing as first‐tier test for fetuses with severe central nervous system structural anomalies
Authors: Yaron Y. , Ofen Glassner V. , Mory A. , Zunz Henig N. , Kurolap A. , Bar Shira A. , Brabbing Goldstein D. , Marom D. , Ben Sira L. , Baris Feldman H. , Malinger G. , Krajden Haratz K. , Reches A. 
Published: March 2022

ABSTRACTObjectivePrenatally detected central nervous system (CNS) anomalies present a diagnostic challenge. In this study, we compared the diagnostic yield of exome sequencing (ES) and chromosomal microarray analysis (CMA) in fetuses with a major CNS anomaly.MethodsThis was a retrospective study of 114 cases referred for genetic evaluation following termination of pregnancy (TOP) due to a major CNS anomaly detected on prenatal ultrasound. All fetuses were first analyzed by CMA. All CMA‐negative cases were offered ES. CMA‐positive cases were reanalyzed using ES to assess its ability to detect copy‐number variants (CNVs).ResultsCMA identified a pathogenic or likely pathogenic (P/LP) CNV in 11/114 (10%) cases. Eighty‐six CMA‐negative cases were analyzed using ES, which detected P/LP sequence variants in 38/86 (44%). Among recurrent cases (i.e. cases with a previously affected pregnancy), the incidence of P/LP sequence variants was non‐significantly higher compared with non‐recurrent ones (12/19 (63%) vs 26/67 (39%); P = 0.06). Among the 38 cases with an ES diagnosis, 20 (53%) were inherited and carried a significant risk of recurrence. Reanalysis of 10 CMA‐positive cases by ES demonstrated that the bioinformatics pipeline used for sequence variant analysis also detected all P/LP CNVs, as well as three previously known non‐causative CNVs.ConclusionsIn our study, ES provided a high diagnostic yield (> 50%) in fetuses with severe CNS structural anomalies, which may have been partly due to the highly selected case series that included post‐TOP cases from a specialist referral center. These data suggest that ES may be considered as a first‐tier test for the prenatal diagnosis of major fetal CNS anomalies, detecting both P/LP sequence variants and CNVs. This is of particular importance given the time constraints of an ongoing pregnancy and the risk of recurrence in future pregnancies. © 2022 The Authors. Ultrasound in Obstetrics & Gynecology published by John Wiley & Sons Ltd on behalf of International Society of Ultrasound in Obstetrics and Gynecology.
Perinatal outcomes of fetoscopic laser surgery for twin–twin transfusion syndrome in triplet pregnancy: cohort study, systematic review and meta‐analysis
Authors: Mustafa H. J. , Javinani A. , Krispin E. , Tadbiri H. , Shamshirsaz A. A. , Espinoza J. , Nassr A. A. , Donepudi R. , Belfort M. A. , Sanz Cortes M. , Harman C. , Turan O. M. 
Published: March 2022

ABSTRACTObjectivesThe aims of this study were to investigate the perinatal outcome of dichorionic triamniotic (DCTA) and monochorionic triamniotic (MCTA) triplet pregnancies complicated by twin–twin transfusion syndrome (TTTS) treated with fetoscopic laser photocoagulation (FLP) in two academic fetal centers, and to conduct a systematic review of previously published data to investigate perinatal survival in this targeted population.MethodsThe first part of the study was a retrospective cohort study of prospectively collected data of consecutive triplet pregnancies with TTTS that underwent FLP at two fetal treatment centers between 2012 and 2020. Demographic, preoperative and operative variables and postoperative outcome were collected. Perinatal outcomes were investigated. The second part of the study was a systematic review and meta‐analysis of studies evaluating the outcome of DCTA and/or MCTA triplet pregnancies, including our cohort study. PubMed, Web of Science and Scopus were searched from inception to September 2020. Primary outcomes were fetal survival (survival to birth), neonatal survival (survival to 28 days of age) and gestational age (GA) at birth.ResultsA total of 31 sets of triplets with TTTS managed with FLP were included in the cohort study. Of these, 24 were DCTA and seven were MCTA. There were no significant differences in preoperative and operative variables between the two groups. There were also no significant differences between groups in GA at delivery or perinatal survival rate, including fetal and neonatal survival of at least one triplet, at least two triplets and all three triplets. Nine studies, including our cohort study, were included in the systematic review (156 DCTA and 37 MCTA triplet pregnancies treated with FLP). The overall fetal and neonatal survival was 79% (95% CI, 75–83%) and 75% (95% CI, 71–79%), respectively, in DCTA cases and 74% (95% CI, 52–92%) and 71% (95% CI, 49–89%), respectively, in MCTA cases. The rate of preterm birth before 28 weeks and before 32 weeks' gestation was 14% (95% CI, 4–29%) and 61% (95% CI, 50–72%), respectively, in DCTA triplets and 21% (95% CI, 3–45%) and 82% (95% CI, 62–96%), respectively, in MCTA triplets.ConclusionsTriplet pregnancies with TTTS are at high risk of adverse perinatal outcome and preterm birth, regardless of chorionicity. The rate of survival after FLP in MCTA triplets was higher in our study than that reported in previous studies and is currently comparable with survival in DCTA triplets, which could be due to improved surgical skills. © 2022 International Society of Ultrasound in Obstetrics and Gynecology.
Entfernung (kurzkettiger) PFAS mit einem neuen Ansatz aus Aktivkohle und Ionenaustauscher
Authors: Riegel Marcel 
Published: March 2022

ZusammenfassungZur Entfernung von poly‐ und perfluorierten Alkylverbindungen (PFAS) wurde ein zweistufiges Verfahrenskonzept getestet, bei dem die langkettigen PFAS mittels Aktivkohlefiltration und die kurzkettigen PFAS in einer anschließenden Behandlung mittels Ionenaustauscher entfernt werden. Der Betrieb des Ionenaustauschers erfolgt hierbei zyklisch durch Beladung und Regeneration mit Natronlauge. Die im basischen Regenerat vorliegenden kurzkettigen PFAS sollen anschließend elektrochemisch mineralisiert werden. Beim Betrieb des Ionenaustauschers wurden über 14 Zyklen aus Beladung und Regeneration Entfernungsraten der beiden Substanzen PFBA und PFPeA von 80 bis > 95 % ermittelt. Ferner konnten sehr hohe Ausbeuten hinsichtlich behandelter Wassermenge und anfallendem, PFAS‐haltigem Regenerat zwischen 99 und 99,5 % erzielt werden. Dadurch resultiert ein sehr geringes Wasservolumen, das anschließend energieintensiv zur PFAS‐Zerstörung behandelt werden muss.
Light bending from eikonal in worldline quantum field theory
Authors: Bastianelli Fiorenzo , Comberiati Francesco , de la Cruz Leonardo 
Published: March 2022

Abstract
Using the worldline quantum field theory (WQFT) formalism for classical scattering, we study the deflection of light by a heavy massive spinless/spinning object. WQFT requires the use of the worldline dressed propagator of a photon in a gravitational background, which we construct from first principles. The action required to set up the worldline path integral is constructed using auxiliary variables, which describe dynamically the spin degrees of freedom of the photon and take care of path ordering. We test the fully regulated path integral by recovering the photon-photon-graviton vertex. With the dressed propagator at hand, we follow the WQFT procedure by setting up the partition function and deriving the Feynman rules which can be used to evaluate it perturbatively. These rules depend on the auxiliary variables. The latter ultimately do not contribute in the geometric-optics regime, which realizes the equivalence between the scattering of a photon and a massive scalar with that of a massless and a massive scalar. Then, the calculation of the eikonal phase and the deflection angle simplifies considerably. Using the eikonal phase defined in terms of the partition function, we calculate explicitly the deflection angle at NLO in the spinless case, and at LO in the spinning case up to quadratic order in spin.
Prevalence and molecular identification of zoonotic Anisakis and Pseudoterranova species in fish destined to human consumption in Chile
Authors: Muñoz-Caro Tamara , Machuca Alvaro , Morales Pamela , Verdugo Javiera , Reyes Rodrigo , García Macarena , Rutaihwa Liliana , Schindler Tobias , Poppert Sven , Taubert Anja , Hermosilla Carlos 
Published: March 2022

Abstract
Zoonotic larvae of the family Anisakidae found in several fish species represent a serious risk in public health since they may cause food-borne anisakidosis in humans. Chile has culinary preferences including eating raw fish in many traditional preparations. In the present study, a total of 180 fish specimens representing three different fish species, i.e., Chilean hake (Merluccius gayi), snoek (Thyrsites atun), and sea bream (Brama australis), were caught at central coast of Chile. Parasitological examination was performed on musculature and abdominal cavity for subsequent extraction and quantification of anisakid larvae. Estimation of infection parameters, such as prevalence, was performed indicating 100% (CI: 0.94–1.0) prevalence of anisakid L3 in Chilean hakes and snoeks. Moreover, sea breams reached a prevalence of 35% (CI: 0.23–0.48). Prevalence of anisakid larvae in muscle was also analyzed showing values of 18.6% (CI: 0.097–0.309) in Chilean hakes, 15% (CI: 0.07–0.26) in snoeks, and 1.7% (CI: 0–0.089) in sea breams. Meanwhile, prevalence of anisakid larvae in internal organs showed highest values for peritoneum (100% and 83.3%) for snoeks and Chilean hakes, respectively, for liver (96.7%) and gonads (86.6%) in Chilean hakes, and for intestine (98.3%) in snoeks. Molecular analysis of collected anisakid L3 unveiled presence of two potentially zoonotic nematode species, i.e., Pseudoterranova cattani and Anisakis pegreffii. P. cattani was found in Chilean hakes and snoeks being the first molecular host species report for Chilean snoeks. Besides, A. pegreffii was also identified in these species being the first molecular report on this regard. These findings are relevant for better understanding of epidemiology of anisakiasis in Chilean coasts and for public health issues considering potential risk of human population due to its culinary preferences in eating raw fish.
Can statistical remote sensing aid in predicting the potential productivity of inland lakes? Case study: Lake Qaroun, Egypt
Authors: Mohamed Hagar Mahmoud , Khalil Magdy Tawfik , El-Kafrawy Sameh Bakr , El-Zeiny Ahmed Mohamed , Khalifa Nehad , Emam Wiame Waheed Mahmoud 
Published: March 2022

AbstractThis study aimed at creating a sustainable and inexpensive Landsat-based electrical conductivity model that can easily notify fisheries managers of changes in electrical conductivity and hence the potential fish yield of Lake Qaroun in Egypt. The study integrated geospatial technology, field measurements, mathematical computations, and fish yield empirical model into the adopted methodology. Seventeen sampling sites covering the entire study area were selected to measure the electrical conductivity (EC; mS/cm) and water depths (D; m) of Lake Qaroun, Egypt, during November 2018. Spatial analysis tools within ArcGIS were used to extract EC data from non-surveyed sites. A high-resolution Sentinel-2B MSI and a cloud-free medium-resolution Landsat-8 OLI scenes for Lake Qaroun were used for morphometric and regression analyses, respectively. For regression, 75% of the dataset was used to build up the regression model, while the remaining 25% was used for validation. The study selected Landsat band ratios that correlated with the highest certainty (R > 0.80) with the examined EC. Stepwise regression model was then developed to predict EC from Landsat-8 data. In choosing the best regression model, the study selected the significant model (P < 0.05) with the highest coefficient of determination (R2) and the least error metrics. Finally, the developed model was applied in calculating the potential yield of Lake Qaroun. The innovative EC model derived in the current study using Landsat-8 OLI for Lake Qaroun showed a very good performance in estimating 95% of EC values significantly with high acceptable accuracy. In closure, the model can be used very efficiently as a decision support tool in assisting managers not only in monitoring the lake’s electrical conductivity regularly, during the month of November, but also in making preliminary estimates of the lake’s potential yield.
Fear of childbirth postpartum and its correlation with post-traumatic stress symptoms and quality of life among women with birth complications — a cross-sectional study
Authors: Grundström Hanna , Malmquist Anna , Ivarsson Alice , Torbjörnsson Elin , Walz Malin , Nieminen Katri 
Published: March 2022

AbstractThe primary aim of the study was to analyze differences in post-traumatic stress symptoms (PTSS) and quality of life (QoL) between women with and without severe fear of childbirth postpartum (PP FOC). The secondary aims were to analyze the correlation between PP FOC and PTSS, and PP FOC and QoL, in women undergoing complicated childbirth. This cross-sectional study was conducted in South-East Sweden. Women aged ≥ 18 years who had undergone complicated childbirth (i.e., acute or emergency cesarean section, vacuum extraction, child in need of neonatal care, manual placenta removal, sphincter rupture, shoulder dystocia, or hemorrhage ≥ 1000 ml) were invited. Seventy-six women answered demographic questions and three validated instruments measuring PP FOC, PTSS, and QoL. The study population was divided into two sub groups: severe PP FOC or no severe PP FOC. Statistical analyses were conducted using Mann–Whitney U-test, chi-square test or Fisher’s exact test, and Spearman’s rank-order correlation. Severe PP FOC was reported by 29% of the women, and 18% reported PTSS indicating post-traumatic stress disorder. Women with severe PP FOC reported significantly higher levels of PTSS, and significantly lower QoL in five dimensions: physical role functioning, emotional role functioning, energy/fatigue, emotional well-being, and social functioning. There was a positive significant correlation between level of PP FOC and PTSS. There were also significant negative correlations between level of PP FOC and most of the QoL dimensions. In conclusion, almost one-third of the women with complicated childbirth reported severe PP FOC, and almost one-fifth reported PTSS indicating post-traumatic stress disorder. PP FOC correlated with PTSS and deteriorated QoL.
Biogeochemical feedbacks may amplify ongoing and future ocean deoxygenation: a case study from the Peruvian oxygen minimum zone
Authors: Wallmann Klaus , José Yonss S. , Hopwood Mark J. , Somes Christopher J. , Dale Andrew W. , Scholz Florian , Achterberg Eric P. , Oschlies Andreas 
Published: March 2022

AbstractA new box model is employed to simulate the oxygen-dependent cycling of nutrients in the Peruvian oxygen minimum zone (OMZ). Model results and data for the present state of the OMZ indicate that dissolved iron is the limiting nutrient for primary production and is provided by the release of dissolved ferrous iron from shelf and slope sediments. Most of the removal of reactive nitrogen occurs by anaerobic oxidation of ammonium where ammonium is delivered by aerobic organic nitrogen degradation. Model experiments simulating the effects of ocean deoxygenation and warming show that the productivity of the Peruvian OMZ will increase due to the enhanced release of dissolved iron from shelf and slope sediments. A positive feedback loop rooted in the oxygen-dependent benthic iron release amplifies, both, the productivity rise and oxygen decline in ambient bottom waters. Hence, a 1% decline in oxygen supply reduces oxygen concentrations in sub-surface waters of the continental margin by 22%. The trend towards enhanced productivity and amplified deoxygenation will continue until further phytoplankton growth is limited by the loss of reactive nitrogen. Under nitrogen-limitation, the redox state of the OMZ is stabilized by negative feedbacks. A further increase in productivity and transition to sulfidic conditions is only possible if the rate of nitrogen fixation increases drastically under anoxic conditions. Such a transition would lead to a wide-spread accumulation of toxic sulfide with detrimental consequences for fishery yields in the Peruvian OMZ that currently provides a significant fraction of the global fish catch.