bluuebunny/crossref_metadata_2025_split huggingface dataset:
COMPARISON ANALYSIS OF INCOME ON ORGANIC VEGETABLE AND INORGANIC VEGETABLES IN AMBON ISLAND
Authors: Leatemia Ester Dorina , Luhukay Johanna M 
Published: December 2022

Increasing agricultural production by using chemical fertilizers and pesticides continuously and exceeding the threshold for use will cause new problems for health and the surrounding environment. Organic vegetable farming has been started because people are becoming aware of the dangers of using chemical pesticides. This study aims to describe the characteristics of organic and inorganic vegetable farming, describe the marketing of organic and inorganic vegetables and analyze the comparison of organic and inorganic vegetable farming income on Ambon Island. The method used in sampling is the census method. The results showed that implementation of organic and inorganic vegetable farming in Telaga Kodok Hamlet and Waiheru Village there were differences in vegetable cultivation both in land preparation and processing, seeding, fertilization, and controlling plant pest organisms (OPT). Most farmers (80%) sell organic vegetables to distributors (modern retail markets) when compared to selling vegetables to consumers (20%). The reason farmers sell organic vegetables to distributors (modern retail markets) is they are partners. Farmers in Waiheru Village sell their inorganic vegetable products to retailers (73.32%) when compared to being sold to collectors (13.34 percent) and sold directly to consumers (13.34 percent). The income of organic vegetable farmers is higher (Rp. 2,338,580.29) when compared to the income of inorganic vegetable farmers (Rp. 1,292,187.84). This is due to the difference in the selling price of organic vegetables and inorganic vegetables, and the production costs incurred by organic vegetable farmers are smaller than those of inorganic vegetable farmers.
Keywords: income, marketing, organic vegetables, inorganic vegetables
PENGARUH PAD DAN BELANJA MODAL TERHADAP PDRB KABUPATEN DI PULAU SUMBA TAHUN 2015 - 2020
Authors: Ama Defresto Risman Tamu , Renggo Yuniarti Reny 
Published: December 2022

Penelitian ini bertujuan untuk mengetahui pengaruh PAD, Belanja Modal terhadap Produk Domestik Regional Bruto Kabupaten di Pulau Sumba Tahun 2020. Teknik pengumpulan data dengan menggunakan data sekunder yaitu dari website resmi Badan Pusat Statistik Provinsi NTT. teknik analisis data yang digunakan adalah Teknik Regresi Data Panel dengan pengujian Uji Statistik yaitu Uji R-Square,Uji Simultan dan Uji Parsial. Hasil penelitian menunjukkan bahwa PAD berpengaruh positif tidak signifikan terhadap Produk Domestik Regional Bruto dan Belanja Modal berpengaruh positif signifikan terhadap Produk Domestik Regional Bruto
Meningkatnya hasil belajar siswa di lingkungan Global Islamic Boarding School dengan menggunakan PCK dan HOTS
Authors: Amanda Dhea , Karlina Ni Wayan 
Published: December 2022

Dalam melaksanakan pembelajaran seorang pendidik sering mengalami kesulitan dalam menggunakan metode dan model yang sesuai dengan situasi kelas. Era persaingan global saat ini menuntut adanya suatu pembelajaran yang bermutu untuk memberikan fasilitas bagi anak didik dalam mengembangkan kecakapan, keterampilan dan kemampuan sebagai modal untuk menghadapi tantangan di kehidupan global. Dengan pendidik menggunakan cara pedagogical Content knowledge dan High Order Thingking Skills mendapatkan keuntungan baik untuk guru maupun siswa, serta menerapkan literasi numerasi pendidik mampu meningkatkan kompentensi siswa dalam belajar. Hasil pretest yang di lakukan di Global Islamic Boarding School yaitu 49,0 meningkat nilai post-test menjadi 57,04 . Sedangkan Numerasi yaitu dari 30,12 meningkat menjadi 49,58. Dengan adanya peningkatan nilai dari siswa, pendidik mampu meningkatkan cara agar siswa mampu menerima materi dengan baik serta mudah dipahami.
Abstract. In carrying out learning an educator often has difficulty in using methods and models that are appropriate to the classroom situation. The current era of global competition demands quality learning to provide facilities for students to develop skills, and abilities as capital to face the challenges of global life. With educators using pedagogical Content knowledge and High Order Thinking Skills, they get benefits for both teachers and students, and applying numeracy literacy educators are able to improve student competence in learning. The results of the pretest conducted at the Global Islamic Boarding School, which was 49.0, increased the post-test score to 57.04. Meanwhile, the Numeration from 30.12 increased to 49.58. With an increase in the value of students, educators are able to improve the way that students are able to receive material well and easily accessible.
Hasil belajar dan keterampilan berpikir kritis peserta didik menggunakan LKPD-elektronik konsep virus
Authors: Adawiyah Rabiatul , Zaini Muhammad , Ajizah Aulia 
Published: December 2022

Hasil belajar kognitif dan keterampilan berpikir kritis peserta didik harus ditingkatkan oleh lembaga pendidikan pada masa pandemi COVID-19. Kegiatan pembelajaran yang dilaksanakan secara online perlu diintegrasikan dengan kecenderungan berpikir kritis. Penelitian ini bertujuan untuk menganalisis pengaruh penggunaan LKPD-Elektronik terhadap hasil belajar kognitif produk dan kognitif proses pada konsep virus, dan pengaruhnya terhadap peningkatan keterampilan berpikir kritis. Penelitian hasil belajar kognitif produk dan kognitif proses menggunakan penelitian quasi eskperiment dengan teknik purposive sampling, sedangkan keterampilan berpikir kritis menggunakan kelas perlakuan dan kontrol. Teknik analisis data hasil belajar menggunakan analisis kovarian dianalisis dengan uji Statistical Product and Service Solutions (Program SPSS 22). Data keterampilan berpikir kritis dianalisis melalui teknik deskriptif dengan penskoran kategorisasi. Hasil penelitian menunjukkan LKPD-Elektronik berpengaruh signifikan terhadap hasil belajar kognitif produk dan kognitif proses dengan signifikansi 0,000, dan aspek keterampilan berpikir kritis dengan rata-rata kategori baik. Keterampilan berpikir kritis bermanfaat bagi peserta didik memahami materi pelajaran dan menempatkan diri dalam kehidupan sehari-hari.
Abstract. Educational institutions must improve cognitive learning outcomes and students' critical thinking skills during the COVID-19 pandemic. Learning activities carried out online need to be integrated with critical thinking tendencies. This study aims to analyze the effect of electronic worksheets on product cognitive learning outcomes and cognitive processes on the concept of viruses and their effect on increasing critical thinking skills. The research on product cognitive learning outcomes and cognitive processes used a quasi-experimental study with a purposive sampling technique, while critical thinking skills used treatment and control classes. The data analysis technique for learning outcomes uses covariance analysis through the Statistical Product and Service Solutions test (SPSS 22 Program). Critical thinking skills data are analyzed with descriptive techniques with categorization scoring. The results showed that LKPD-Electronic significantly affected product cognitive learning outcomes and cognitive processes with a significance of 0.000, and aspects of critical thinking skills with an average of good categories. Critical thinking skills are helpful for students to understand the subject matter and place themselves in everyday life.
Incentivos y riesgos fiscales y laborales de las Sociedades Cooperativas de Producción en México
Authors: Carmona López Antonio Maximino , Ruíz Martínez Alfredo , Ramos Soto Ana Luz 
Published: December 2022

El objetivo del presente trabajo de investigación es analizar los incentivos fiscales y el financiamiento público destinado al fomento de las Sociedades Cooperativas de Producción en México, así como la participación de las cooperativas en actividades que puedan representar transgresiones a las leyes fiscales y laborales de nuestro país. Los resultados muestran que la crisis económica de la década de los ochenta del siglo pasado obligó al cambio del modelo económico y las cooperativas fueron relegadas de las políticas públicas. La relación con el Estado se fracturó nuevamente en el año del 2013 cuando se imputaron a las empresas cooperativas la realización de operaciones fraudulentas para omitir el pago de contribuciones federales, como consecuencia, se eliminaron los regímenes especiales de tributación y se redujo el financiamiento público. Sin embargo, la información publicada por las autoridades administrativas del país no aporta evidencias empíricas para asegurar que en los últimos 11 años las organizaciones cooperativas constituyan un factor de riesgo para la hacienda pública federal y la estabilidad laboral de los trabajadores. La presente investigación aplica un enfoque mixto, lo que significa la combinación de métodos y técnicas de las investigaciones del tipo cuantitativo y cualitativo. En el primer caso se recurre al método hipotético deductivo y en el segundo a la teoría fundamentada y a la triangulación hermenéutica. Los datos provienen de la página electrónica de las agencias gubernamentales y la consulta directa al instituto responsable de proporcionar la información pública a los ciudadanos.
Characteristics and Treatment Rate of Patients With Hepatitis C Virus Infection in the Direct-Acting Antiviral Era and During the COVID-19 Pandemic in the United States
Authors: Nguyen Vy H. , Kam Leslie , Yeo Yee Hui , Huang Daniel Q. , Henry Linda , Cheung Ramsey , Nguyen Mindie H. 
Published: December 2022

ImportanceClinical data on hepatitis C virus (HCV) treatment rates in the United States are sparse.ObjectiveTo evaluate HCV treatment rates in the era of direct-acting antivirals (DAAs).Design, Setting, and ParticipantsThis retrospective cohort study used data from the deidentified Optum Cliniformatics Data Mart Database (2014-2021) on patients with HCV in the DAA and COVID-19 eras. The database includes patients with private health insurance in the US.Main Outcomes and MeasuresThe treatment rate and changes over time were assessed with adjusted log-binomial regression, and factors associated with treatment were examined using multivariable logistic regression.ResultsA total of 133 348 patients with HCV (79 567 [59.7%] men; mean [SD] age, 59.7 [12.3] years; 4448 [3.3%] Asian, 24 662 [18.5%] Black, and 74 750 [56.1%] White individuals) were included; 38 180 (26.8%) had HCV RNA data, and of those, 20 277 (53.1%) had positive HCV RNA. Overall, 13 214 patients with positive HCV RNA tests (65.2%) received DAA treatment; 6456 of 6634 patients treated with DAAs (97.3%) achieved sustained virologic response. After adjusting for age, sex, and race and ethnicity, the treatment rate in 2018 was 0.5 times greater than the rate in 2014 (adjusted prevalence ratio, 1.50; 95% CI, 1.42-1.59) but declined after 2018, decreasing from 64.8% to 61.2%, and especially after 2019, when it decreased to less than 60% (P &amp;lt; .001). The number of patients with viremic HCV identified in between April 2020 and March 2021 also decreased to 496 from 2761 and 3258 in the preceding 2 years. Receiving care from a gastroenterologist or infectious disease specialist with advanced care practitioner (ie, nurse practitioner, physician assistant, or clinical nurse specialist) was independently associated with greater odds of DAA treatment (adjusted odds ratio [aOR], 1.64; 95% CI, 1.07-1.50). Patients with decompensated cirrhosis and/or hepatocellular carcinoma (HCC) were 31% less likely to receive treatment compared with those without (aOR, 0.69; 95% CI, 0.54-0.90).Conclusions and RelevanceIn this cohort study, less than two-thirds of insured patients with viremic HCV received DAA treatment, with declines in both the treatment rate and the number of viremic HCV diagnoses since 2019 and especially during the COVID-19 pandemic. Further efforts are needed to increase HCV diagnosis and treatment, especially for those with cirrhosis and HCC. An urgent call for nationwide actions to improve access to DAA treatment, community outreach programs, and specialists through referral pipelines is needed in the United States to stay on track to meet the World Health Organization goal of reducing the burden of viral hepatitis with the eventual goal to eliminate viral hepatitis.
Effect of Early High-Dose Recombinant Human Erythropoietin on Behavior and Quality of Life in Children Aged 5 Years Born Very Preterm
Authors: Picotti Eleonora , Reinelt Tilman , Koller Brigitte , Bucher Hans Ulrich , Rüegger Christoph M. , Fauchère Jean-Claude , Natalucci Giancarlo ,   Swiss EPO Neuroprotection Trial Group, Zellinger Georg , Pasquier Sylviane , Capone Andrea , Bührer Christoph , Glanzmann René , Schulzke Sven , Weber Peter , Scharrer Brigitte , Bär Walter , Keller Elmar , Killer Christa , Pfister Riccardo , Krämer Karin , Hüppi Petra S , Borradori-Tolsa Cristina , Latal Beatrix , Bucher Hans Ulrich , Fauchère Jean-Claude , Welmann Sven , Koller Brigitte , Natalucci Giancarlo 
Published: December 2022

ImportanceIn light of the promising neuroprotective properties of recombinant human erythropoietin (RHEpo), the Swiss EPO Neuroprotection Trial was started to investigate its effect on neurodevelopment in very preterm infants. The results of the primary and secondary outcome analysis did not show any effect of RHEpo on cognitive performance, neuromotor outcomes, or somatic growth of the study participants at ages 2 or 5 years.ObjectiveTo investigate whether early high-dose RHEpo improves behavioral outcomes and health-related quality of life (HRQoL) at age 5 years.Design, Setting, and ParticipantsThis was a prespecified secondary analysis of the double-blind, placebo-controlled, multicenter Swiss EPO Neuroprotection randomized clinical trial, which was conducted at 5 level-III perinatal centers in Switzerland. Infants born between 26 weeks 0 days’ and 31 weeks 6 days’ gestation were recruited between 2005 and 2012 and followed-up until age 5 years (last follow-up in 2018). Data were analyzed from January 6 to December 31, 2021.InterventionsInfants were assigned to receive either RHEpo (3000 IU/kg) or placebo (saline, 0.9%) intravenously 3 times within the first 42 hours after birth.Main Outcomes and MeasuresThe prespecified parent-reported measures of behavioral outcomes and health-related quality of life (HRQoL) of their children at the age of 5 years were assessed by two standardized questionnaires: the Strengths and Difficulties Questionnaire (behavioral outcomes) and the KIDSCREEN-27 (HRQoL).ResultsAmong 448 randomized infants, 228 infants were assigned to the RHEpo group and 220 infants were assigned to the placebo group. Questionnaire data were available for 317 children (71%) at a mean (SD) age of 5.8 (0.4) years (mean [SD] gestational age at birth, 29.3 [1.6] weeks; mean [SD] birth weight 1220 [340] grams; 128 [40%] female infants). At the age 5 years follow-up, the mean (SD) total difficulties score in the RHEpo group (8.41 [5.60] points) was similar to that of the placebo group (7.76 [4.81]) (P = .37). There were no statistically significant differences between the groups in any other outcome measures.Conclusions and RelevanceThis secondary analysis of a randomized clinical trial showed no evidence for an effect of early high-dose RHEpo administration on behavioral outcomes or HRQoL in children born very preterm at early school age.Trial RegistrationClinicalTrials.gov Identifier: NCT00413946
Psychedelic Drug Legislative Reform and Legalization in the US
Authors: Siegel Joshua S. , Daily James E. , Perry Demetrius A. , Nicol Ginger E. 
Published: December 2022

ImportancePsychedelic drugs are becoming accessible in the US through a patchwork of state legislative reforms. This shift necessitates consensus on treatment models, education and guidance for health care professionals, and planning for implementation and regulation.ObjectiveTo assess trends in psychedelics legislative reform and legalization in the US to provide guidance to health care professionals, policy makers, and the public.Evidence ReviewData were compiled from legislative databases (BillTrack50, LexisNexis, and Ballotpedia) from January 1, 2019, to September 28, 2022. Legislation was identified by searching for terms related to psychedelics (eg, psilocybin, MDMA, peyote, mescaline, ibogaine, LSD, ayahuasca, and DMT). Bills were coded by an attorney along 2 axes: which psychedelic drugs would be affected and in what ways (eg, decriminalization, funding for medical research, and right to try). To explore drivers and rates of legislative reform, data were compared with other state indices including 2020 presidential voting margins and marijuana legislative reform.FindingsTwenty-five states have considered 74 bills (69 legislative initiatives, 5 ballot measures); 10 bills were enacted, and 32 were still active. The number of psychedelic reform bills introduced during each calendar year increased steadily from 5 in 2019 to 6 in 2020, 27 in 2021, and 36 in 2022. Nearly all bills specified psilocybin (67 [90%]), and many also included MDMA (3,4-methylenedioxy-methamphetamine; 27 [36%]). While bills varied in their framework, most (43 [58%]) proposed decriminalization, of which few delineated medical oversight (10 of 43 [23%]) or training and/or licensure requirements (15 of 43 [35%]). In general, bills contained less regulatory guidance than the enacted Oregon Measure 109. While early legislative efforts occurred in liberal states, the margin between liberal and conservative states has decreased over time (although the difference was not significant), suggesting that psychedelic drug reform is becoming a bipartisan issue. In addition, an analytic model based on marijuana legalization projected that a majority of states will legalize psychedelics by 2034 to 2037.Conclusions and RelevanceLegislative reform for psychedelic drugs has been proceeding in a rapid, patchwork fashion in the US. Further consideration should be given to key health care issues such as establishing (1) standards for drugs procured outside the medical establishment, (2) licensure criteria for prescribers and therapists, (3) clinical and billing infrastructure, (4) potential contraindications, and (5) use in special populations like youths, older adults, and pregnant individuals.
Brain proteome‐wide association study linking‐genes in multiple sclerosis pathogenesis
Authors: Jia Tingting , Ma Yanni , Qin Fengqin , Han Feng , Zhang Chengcheng 
Published: December 2022

AbstractObjectivesTo identify genes that confer MS risk via the alteration of cis‐regulated protein abundance and verify their aberrant expression in human brain.MethodsUtilizing a two‐stage proteome‐wide association study (PWAS) design, MS GWAS data (N = 41,505) was respectively integrated with two distinct human brain proteomes from the dorsolateral prefrontal cortex, including ROSMAP (N = 376) in the discovery stage and Banner (N = 152) in the confirmation stage. In the following, Bayesian colocalization analysis was conducted for GWAS and protein quantitative trait loci signals to prioritize candidate genes. Differential expression analysis was then used to verify the dysregulation of risk genes in white matter and gray matter for evidence at the transcription level.ResultsA total of 51 genes whose protein abundance had association with the MS risk were identified, of which 18 genes overlapped in the discovery and confirmation PWAS. Bayesian colocalization indicated six causal genes with genetic risk variants for the MS risk. The differential expression analysis of SHMT1 (PFDR = 4.82 × 10−2), FAM120B (PFDR = 8.13 × 10−4) in white matter and ICA1L (PFDR = 3.44 × 10−2) in gray matter confirmed the dysregulation at the transcription level. Further investigation of expression found SHMT1 significantly up‐regulated in white matter lesion, and FAM120B up‐regulated in both white matter lesion and normal appearing white matter. ICA1L was down‐regulated in both gray matter lesion and normal appearing gray matter.InterpretationDysregulation of SHMT1, FAM120B and ICA1L may confer MS risk. Our findings shed new light on the pathogenesis of MS and prioritized promising targets for future therapy research.
Metal Single‐Site Molecular Complex–MXene Heteroelectrocatalysts Interspersed Graphene Nanonetwork for Efficient Dual‐Task of Water Splitting and Metal–Air Batteries
Authors: Nguyen Thanh Hai , Tran Phan Khanh Linh , Dinh Van An , Tran Duy Thanh , Kim Nam Hoon , Lee Joong Hee 
Published: December 2022

AbstractDevelopment of multifunctional electrocatalysts with high efficiency and stability is of great interest in recent energy conversion technologies. Herein, a novel heteroelectrocatalyst of molecular iron complex (FeMC)‐carbide MXene (Mo2TiC2Tx) uniformly embedded in a 3D graphene‐based hierarchical network (GrH) is rationally designed. The coexistence of FeMC and MXene with their unique interactions triggers optimum electronic properties, rich multiple active sites, and favorite free adsorption energy for excellent trifunctional catalytic activities. Meanwhile, the highly porous GrH effectively promotes a multichannel architecture for charge transfer and gas/ion diffusion to improve stability. Therefore, the FeMC–MXene/GrH results in superb performances towards oxygen reduction reaction (ORR), oxygen evolution reaction (OER), and hydrogen evolution reaction (HER) in alkaline medium. The practical tests indicate that Zn/Al–air batteries derived from FeMC–MXene/GrH cathodic electrodes produce high power densities of 165.6 and 172.7 mW cm−2, respectively. Impressively, the liquid‐state Zn–air battery delivers excellent cycling stability of over 1100 h. In addition, the alkaline water electrolyzer induces a low cell voltage of 1.55 V at 10 mA cm−2 and 1.86 V at 0.4 A cm−2 in 30 wt.% KOH at 80 °C, surpassing recent reports. The achievements suggest an exciting multifunctional electrocatalyst for electrochemical energy applications.
Real‐Time Non‐Driving Behavior Recognition Using Deep Learning‐Assisted Triboelectric Sensors in Conditionally Automated Driving
Authors: Zhang Haodong , Tan Haiqiu , Wang Wuhong , Li Zhihao , Chen Facheng , Jiang Xiaobei , Lu Xiao , Hu Yanqiang , Li Lizhou , Zhang Jie , Si Yihao , Wang Xiaoli , Bengler Klaus 
Published: December 2022

AbstractReal‐time recognition of non‐driving behaviors is of great importance in conditionally automated driving, as it determines the takeover time budget, which in turn has a huge impact on the performance of the takeover. Here, a novel real‐time non‐driving behavior recognition system (RNBRS) integrating self‐powered, low‐cost, easy‐to‐manufacture triboelectric sensors, and a deep learning model is proposed. The structure, working mechanism, and electrical characteristics of triboelectric sensors are investigated and analyzed. Through the ingenious structural design of single‐electrode triboelectric sensors and driving simulation experiments under conditional automated driving, non‐driving behaviors are captured in the form of electrical signals. A well‐trained long short‐term memory network model is adopted to recognize the five most typical non‐driving behaviors, including phone, console touchpad, driving, monitoring driving, and no operation, and test accuracy of 93.5% is achieved. Demonstration of a set of controlled experiments shows that RNBRS enables vehicles with conditional automation to dynamically adjust takeover time budget based on driver behavior, therefore significantly improving both safety and stability of takeover. This study opens new frontiers for the development of self‐powered electronics and inspires new thoughts on human‐machine interaction and the safety of autonomous vehicles.