Abstract PO-236: Examining racial disparities in lung cancer stage of diagnosis among low-income adults living in the southeastern U.S.
Authors: Richmond Jennifer , Hollister Megan , Milder Cato M. , Schwartz Ann G. , Blume Jeffrey D. , Aldrich Melinda C. 
Published: January 2022

Abstract
Purpose: Black Americans experience poorer lung cancer survival than White Americans. Racial disparities in stage at diagnosis may contribute to these survival differences, but few studies have explored factors leading to racial disparities in lung cancer stage at diagnosis. We aimed to identify multilevel factors contributing to racial disparities in stage of lung cancer presentation. Methods: Using data from the Southern Community Cohort Study (SCCS), we examined factors associated with distant stage among adults diagnosed with incident lung cancer. SCCS participants were prospectively enrolled, primarily from community health centers between 2002 and 2009 across a 12-state area. Incident cancers were identified by linkage with state cancer registries through end of follow-up in 2019. Self-reported social, behavioral, and medical history information were ascertained at baseline via questionnaire. Cumulative exposure smoking histories were identified using the most recent follow-up questionnaires. Residential addresses and National Cancer Institute Comprehensive Cancer Center locations were geocoded, and residential addresses were linked to census data. Logistic and multinomial regression models were used to identify factors predictive of distant stage diagnosis. Penalized regression was used to shrink the predictor space of these models when necessary. Findings were replicated in an independent population. Results: Among 1,672 incident SCCS lung cancer cases (35% White, 61% Black, and 3% other self-reported race), a greater percentage of Black participants than White participants were diagnosed with distant stage lung cancer (56.4% vs 49.4%, respectively). Overall, Black participants had greater odds of distant vs local stage compared to White participants (odds ratio (OR) = 1.28, 95% confidence interval (CI): 1.05-1.58). Greater area deprivation was also associated with distant lung cancer stage (OR = 1.55, 95% CI: 1.17-2.04). After controlling for individual and area-level factors, there was no significant difference in the odds of distant stage disease for Black participants compared to White participants (OR = 1.03, 95% CI: 0.80-1.33). Significant interactions between race and area deprivation index were not observed. However, greater residential distance from a comprehensive cancer center was significantly associated with increased odds of distant stage disease in the final model (OR = 1.04, 95% CI: 1.00-1.08). No significant differences were observed in the odds of distant stage lung cancer among Black and White participants in the independent population. Conclusions: A greater percentage of Black participants were diagnosed with distant stage lung cancer; however, this disparity dissipated after adjusting for individual and area-level factors. Our findings suggest racial disparities in lung cancer stage at diagnosis may be ameliorated with modifiable factors, such as patient access to high quality cancer centers.
Citation Format: Jennifer Richmond, Megan Hollister, Cato M. Milder, Ann G. Schwartz, Jeffrey D. Blume, Melinda C. Aldrich. Examining racial disparities in lung cancer stage of diagnosis among low-income adults living in the southeastern U.S. [abstract]. In: Proceedings of the AACR Virtual Conference: 14th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2021 Oct 6-8. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2022;31(1 Suppl):Abstract nr PO-236.