bluuebunny/crossref_metadata_2025_split huggingface dataset:
Designing a Predictive Model for Successful Aging among the Elderly Using Machine Learning Techniques
Authors: Ahmadi Maryam , Nopour Raoof , Nasiri Somayeh 
Published: August 2022

Abstract
Background: the aging phenomenon has an increasing trend worldwide which caused the emergence of the SA1 concept. It is believed that the SA prediction model can increase the QoL2 in the elderly by decreasing physical and mental problems and enhancing their social participation. Most previous studies noted that physical and mental disorders affected the QoL in the elderly but didn't pay much attention to the social factors in this respect. Our study aimed to build a prediction model for SA based on the physical, mental, and social factors by considering all factors affecting SA.Materials and methods: in this descriptive, applied, and retrospective study, the data of 975 related to SA and non-SA of the elderly were investigated. We used the Chi-square test at P<0.05 to determine the best factors affecting the SA. The AB3, J-48, RF4, ANN5, SVM6, BLR7, and NB8 algorithms were used for building the prediction models. To get the best model predicting the SA, we compared them using the sensitivity, specificity, accuracy, F-measure, and AUC. Results: The Chi-square test showed that 28 variables had a meaningful relationship with SA. The results of comparing the ML9 model's performance showed that the RF with sensitivity=0.91, specificity= 0.98, accuracy= 0.95, F-test=0.9, and AUC-test= 0.884 is the best model for predicting the SA. Conclusion: using prediction models can increase the QoL in the elderly and consequently reduce the economic cost for people and societies. The RF can be considered an optimal model for predicting SA in the elderly.
A new 68Ga-labeled ornithine for tumor ornithine metabolism PET imaging
Authors: Wang Hongliang , Qin Kaixin , Shi Dongmei , Wu Ping , Hao Xinzhong , Liu Haiyan , Gao Jie , Li Jianguo , Wu Zhifang , Li Sijin 
Published: August 2022

Abstract
Ornithine metabolism plays a vital role in tumorigenesis. For cancer cells, ornithine is mainly used as a substrate for ornithine decarboxylase (ODC) to produce amounts of polyamines. The ODC as a key enzyme of polyamine metabolism has become an important target for cancer diagnosis and treatment. To non-invasively detect the levels of ODC expression in malignant tumors, we have synthesized a novel 68Ga-labeled ornithine analog (68Ga-NOTA-Orn). The synthesis time of 68Ga-NOTA-Orn was about 30 min with a radiochemical yield of 45–50% (uncorrected), and the radiochemical purity was > 98%. 68Ga-NOTA-Orn was stable in saline and rat serum. Cellular uptake and competitive inhibition assays using DU145 and AR42J cells demonstrated that the transport pathway of 68Ga-NOTA-Orn was similar to that of L-ornithine, and it could interact with the ODC after transporting into the cell. Biodistribution and micro-positron emission tomography (Micro-PET) imaging studies showed that 68Ga-NOTA-Orn exhibited rapid tumor uptake and was rapidly excreted through the urinary system. All above results suggested that 68Ga-NOTA-Orn is a novel amino acid metabolic imaging agent with great potential of tumor diagnosis.
The protective effect and mechanism of ISO-1 in cerebral ischemia/reperfusion injury
Authors: Ji Wanli , Ren Yaoxin , Ding Xiangxiang , Dong Yihan , Yuan Bin 
Published: August 2022

Abstract
Macrophage migration inhibitory factor (MIF) is an immune mediator associated with inflammation, which is upregulated after ischemia in brain tissue. ISO-1 is a potent inhibitor of MIF tautomerase and can protect against neurons by reducing the permeability of blood brain barrier (BBB). In this study, we investigated the role of ISO-1 in ischemia / reperfusion injury in the brain by establishing a model of middle cerebral artery occlusion / reperfusion in rats. Rats were randomized into four groups: the sham operation group, the ISO-1group, the cerebral I/R group, and the ISO-1 + I/R group. We evaluated the degree of neurological deficit in each group and measured the volume of cerebral infarction. We detected the expression of MIF in the core necrotic area and penumbra. We detected the expression of apoptosis-related proteins, apoptosis-inducing factor (AIF), endonuclease G (EndoG) and cytochrome c oxidase-IV (COX-IV) in the ischemic penumbra region. The results showed that the expression of MIF in the ischemic penumbra area, while ISO-1 injection was able to alleviate nerve function defect and reduce infarction area. In cerebral ischemic penumbra region, ISO-1 could reduc the expression of Bax and Caspase3, and inhibit the displacement of AIF and EndoG to the nucleus simultaneously. Besides, ISO-1 also exhibited the ability to reduce apotosis. In summary, ISO-1 may inhibit neuronal apoptosis through the endogenous mitochondrial pathway and reduce the injury of brain I/R after ischemic stroke.
A novel, unique four-member protein family involved in extracellular fatty acid binding in Yarrowia lipolytica
Authors: Onésime Djamila , Vidal Léa , Thomas Stéphane , Henry Céline , Martin Véronique , André Gwenaëlle , Kubiak Piotr , Minard Philippe , Celinska Ewelina , Nicaud Jean-Marc 
Published: August 2022

Abstract

Background: Yarrowia lipolytica, a non-conventional oleaginous yeast species, has attracted attention due to its high lipid degradation and accumulation capacity. Y lipolytica is used as a chassis for the production of usual and unusual lipids and lipids derivatives. While genes involved in the intracellular transport and activation of fatty acids in the different cellular compartments have been characterized, no genes involved in fatty acid transport from the extracellular medium into the cell have been identified so far. In this study, we have identified secreted proteins involved in extracellular fatty acid binding.Results: The recent analysis of the Y. lipolytica secretome leads to the identification of a multi-gene family composed of four secreted proteins hereafter named UP1 to UP4. The protein products were efficiently over-expressed individually in native and multi-deletant strain (Q4: Δup1Δup2Δup3Δup4) backgrounds. Phenotype analysis demonstrated the involvement of those proteins in the binding of extracellular fatty acid. Also, deletion of these genes could prevent octanoic acid (C8) toxicity; while their individual over-expression increased sensitivity to its toxic action. The results suggested binding according to aliphatic chain length- and fatty acid concentration-dependent manner. 3D structure modelling supports at a molecular level their role in fatty acid accommodation.Conclusions: Extracellular fatty acid binding proteins were identified for the first time in Y. lipolytica. The new gene family names are proposed eFbp1 to eFbp4. The exact mode of eFbps action remains to be deciphered individually and synergistically, nevertheless, it is expected that the proteins may be relevant in lipid biotechnology, such as improving fatty acid production and/or bioconversion.
Cyber Threat Detection Based On Angle-Based Subspace Anomaly For Machine Learning Applications
Authors: Soumya T. R , Revathy S. 
Published: August 2022

Abstract
In real time applications related to social media, conventional anomaly detection techniques are not applicable as the accuracy is degraded due to higher dimensionality thereby hampering these applications leading to cyber threat. This paper focuses on an approach that can select feature subspaces of social media which have meaningful information and thereby conduct anomaly detection in the projected subspace correspondingly. Major goal is to maintain the accuracy of detection in the circumstance of high dimensionality detecting cyber threat. This approach determines the angle between any of the two lines for one of the anomaly candidate specifically where the first line is in connection with relevant data points along with centers of adjacent points and the other line is any parallel axis line. For a particular candidate in social media, any dimension having smallest angle with the first line is chosen as subspace parallel to the axis. In the projected subspace, the local outlierness is measured for an object by introducing normalized values of Mahalanobis distance. Artificial datasets are constructed for comparing proposed approach of detecting cyber threats in social media comprehensively and found to be accurate for machine learning applications.
Dissipative localised structures for the complex Discrete Ginzburg-Landau equation
Authors: Hennig Dirk , Karachalios Nikos I. , Maraver Jesús Cuevas 
Published: August 2022

Abstract
The discrete complex Ginzburg-Landau equation is a fundamental model for the dynamics of nonlinear lattices incorporating competitive dissipation and energy gain effects. Such mechanisms are of particular importance for the study of survival/destruction of localised structures in many physical situations. In this work, we prove that in the discrete complex Ginzburg-Landau dissipative solitonic waveforms persist for significant times by introducing a dynamical transitivity argument. This argument is based on a combination of the notions of "inviscid limits'' and of the "continuous dependence of solutions on their initial data'', between the dissipative system and its Hamiltonian counterparts. Thereby, it establishes closeness of the solutions of the Ginzburg-Landau lattice to those of the conservative ideals described by the Discrete Nonlinear Schr\"odinger and Ablowitz-Ladik lattices. Such a closeness holds when the initial conditions of the systems are chosen to be sufficiently small in the suitable metrics and for small values of the dissipation or gain strengths. Our numerical findings are found to be in excellent agreement with the analytical predictions for the dynamics of the dissipative bright, dark or even Peregrine-type solitonic waveforms.
The status and challenges of aquaculture development in Dodoma, a semi-arid region in Tanzania
Authors: Mramba Rosemary , Kahindi Emmanuel 
Published: August 2022

Abstract
Demand for fish is growing rapidly in Tanzania due to population growth and rising incomes. However, as fewer wild fish are being caught, there is a gap in fish supply. Aquaculture is a viable alternative source to meet the gap in fish demand. Tanzania has the perfect climate and land for fish farming. Aquaculture in fresh and salt water has grown quickly, yet the potential is not being fully realised. Thus, the study assessed the growth of aquaculture in Dodoma, a rapidly developing semi-arid region of Tanzania, in order to determine its potential, challeges, and solutions. Thirty-six fish farmers from Dodoma urban district were visited and interviewed. The interviews gathered information about management practices, fish yield, and challenges the farmers experienced. The findings indicated that aquaculture in the region began around nine years ago when the region began to expand. The aquaculture includes small-scale pond farming of Nile tilapia (Oreochromis niloticus) and African catfish (Clarias gariepinus). Fish yield was about 1925 kg ha-1 per culture cycle, and fish customers are definitely available. The main challenges were limited supply and high prices of fish feed and seeds, and limited water supply. Use of commercial feeds, pond fertilisation, access to extension services and ownership of a borehole were related to high fish yield. Expansion of aquaculture in the region is possible with the improvement of extension services and training of farmers in proper breeding, feeding, and water management. To decrease water demands, integrated aquaculture, water recycling, and aquaponics should be encouraged.
A deductive design method to simplify ASCE 41-17 nonlinear static procedure preserving adjusted collapse margin ratio of steel moment frames
Authors: Shahrouzi Mohsen , Ebadijalal Mehrdad 
Published: August 2022

Abstract
The present study offers a deductive linear design procedure based on optimally screened designs under nonlinear static procedure (NSP) of ASCE 41-17. A linearization algorithm is proposed for idealizing NSP pushover curves. The subsequent phase inferred a linear static methodology from the design philosophy underlying ASCE 41-17's NSP. The deduced design procedure is applied in providing a set of 6-story optimal SMRF designs under two load patterns: the code-based and the first-mode shape patterns. The optimal designs by the proposed deduced linear procedure are compared with those optimized under ASCE 41-17's NSP using FEMA p695 metrics. Consequently, adjusted collapse margin ratio is evaluated for both design approaches using incremental dynamic analyses. The evaluation results, demonstrates that the deduced linear static design yields comparable outcomes with respect to NSP; without requiring complex inelastic analysis in design steps of ASCE 41-17. Using the code-based lateral load pattern, the linear static design resulted in a greater margin of safety against collapse in heavier designs with respect to applying the first-mode shape. The deduced design procedure yields an idea that supports a seismic design philosophy to prevent conflict between design and retrofit standards.
The temporal precision of audio-visual integration is associated with ten-year fall number but not sensorimotor fall risk in older adults
Authors: Dowd Alan O’ , Hirst Rebecca J. , Setti Annalisa , Donoghue Orna A. , Kenny Rose Anne , Newell Fiona N. 
Published: August 2022

Abstract
Sustained multisensory integration over long inter-stimulus time delays is typically found in older adults, particularly those with a history of falls. However, the extent to which the temporal precision of audio-visual integration is associated with longitudinal fall or fall risk trajectories is unknown. A large sample of older adults (N = 2,319) were grouped into longitudinal trajectories of self-reported fall incidents (i.e., decrease, stable, or increase in number) and, separately, Timed Up and Go (TUG) performance (stable, moderate decline, severe decline). Multisensory integration was measured once as susceptibility to the Sound-Induced Flash Illusion (SIFI) across three stimulus onset asynchronies (SOAs): 70 ms, 150 ms and 230 ms. Older adults with an increasing fall number showed a significantly different pattern of performance on the SIFI than non-fallers, depending on age: the ‘younger’ fallers (53-59 years) showed no difference in illusion susceptibility at 70 ms and 150 ms while the ‘oldest’ fallers (70+ years) showed a larger difference. There was no association between TUG performance trajectories and SIFI susceptibility. These findings suggests that a fall event is associated with distinct temporal patterns of multisensory integration in ageing and have implications for our understanding of the mechanisms underpinning brain health in older age.
Composition, structure and cytochemical characteristics of peripheral blood cells in Paralichthys olivaceus
Authors: Qiang Lu , Wang Xingqiang , Qin Lei , Yan Binlun , Gao Yingli 
Published: August 2022

Abstract
The microstructures, classification, counting and size of peripheral blood cells in Paralichthys olivaceus were observed and measured by Wright-Giemsa staining, and the cytochemical characteristics of peripheral blood cells were investigated by different cytochemical staining methods. Besides, the transmission electron microscope was used to observe the ultrastructures of different cells. The results showed that erythrocytes, thrombocytes and leukocytes constituted the peripheral blood cells in Paralichthys olivaceus, and leukocytes were made of monocytes, neutrophils and thrombocytes. More heterochromatins were found in erythrocytes, thrombocytes and neutrophils, however, monocytes had more organelles with fewer heterochromatins. As for neutrophils, endoplasmic reticulums and phagocytic vesicles were abundant. The number of erythrocytes was the highest, and the size of lymphocytes and thrombocytes was the smallest; while neutrophils were the fewest in number but the largest in size. Lymphocytes were the most abundant in leukocytes, followed by monocytes and neutrophils. The cytochemical staining results showed that all leukocytes were positive for SBB. Most of the lymphocytes were positive for PAS, and monocytes were positive for PAS, ACP and POX. As for neutrophils, ACP and POX were positive. Both monocytes and neutrophils showed positive for SBB, ACP and POX, indicating that the two kinds of cells play a vital role in phagocytosis and bactericidal action. Only lymphocytes were positive for ALP, indicating that they were important in inflammation and immune response. Paralichthys olivaceus shared the characteristics similarities in peripheral blood cells with other fishes. However, obvious differences also existed, which reflected the species speciality. These results could enrich the haematological database of bony fish and provide scientific references for researching the cell function and evaluating the health status in Paralichthys olivaceus based on haematological parameters.
Mannitol or Hypertonic Saline in Traumatic Brain Injury patients: a CENTER-TBI study
Authors: Veen Ernest van , Nieboer Daan , Kompanje Erwin J. O. , Citerio Giuseppe , Stocchetti Nino , Gommers Diederik A. M. P. J. , Menon David K. , Ercole Ari , Maas Andrew I. R. , Lingsma Hester. F. , Jagt Mathieu van der 
Published: August 2022

Abstract
Introduction: Increased intracranial pressure (ICP) is one of the most important modifiable and immediate threats to critically ill patients suffering from traumatic brain injury (TBI). Two hyperosmolar agents (HOA), mannitol and hypertonic saline (HTS) are routinely used in clinical practice to treat increased ICP. We aimed to assess whether a preference for mannitol, HTS or their combined use translated into differences in (functional) outcome.Methods: The CENTER-TBI Study is a prospective multicenter cohort study. For this study, patients with TBI, admitted to the ICU, treated with mannitol and/or HTS, aged ≥16, were included. Patients and centers were differentiated based on treatment preference with mannitol and/or HTS based on structured, data-driven criteria such as first administered HOA at the ICU. We assessed influence of center and patient characteristics in the choice of agent using adjusted multivariate models. Furthermore, we assessed the influence of HOA preference on (functional) outcome using adjusted ordinal and logistic regression models, and instrumental variable analyses.Results: In total, 2056 patients were assessed. Of these, 502 (24%) patients received mannitol and/or HTS on the ICU. The first bolus of a HOA was HTS for 287 (57%) patients, mannitol for 149 (30%) patients, and both for 66 (13%) patients. Two unreactive pupils were more common for patients receiving both (13, 21%), compared to patients receiving HTS (40, 14%), or mannitol (22, 16%). Center, rather than patient characteristics, was independently associated with the preferred choice of HOA (p-value < 0.05). ICU mortality and 6-month functional outcome were similar between patients preferably treated with mannitol compared to HTS (OR = 0.8, CI = 0.4 – 1.7; OR = 1.1, CI = 0.7 – 1.8 respectively). Patients who received both also had a similar ICU mortality and 6-month functional outcome compared to patients receiving HTS (OR = 1.9, CI = 0.7 - 4.9; OR = 0.7, CI = 0.3 – 1.6 respectively).Conclusion: We found between center variability regarding HOA preference. Moreover, we found that center is a more important driver of the choice of HOA than patient characteristics. However, our study indicates that this variability is an acceptable practice given absence of differences in outcomes associated with a specific HOA.
Insight into effects of high intensity ultrasound treatment on foamability and physicochemical properties of frozen egg white protein
Authors: Li Ya , Yu Ling , Wang Lifeng , Xiong Wenfei 
Published: August 2022

Abstract
Frozen storage can greatly improve the shelf life of fresh egg white protein (EWP), but at the same time, it will also lead to the reduction of protein foaming and can not meet the application needs. Herein, high-intensity ultrasound (HIUS) was used to improve the foam characteristics of EWP in different frozen storage periods. The results showed that compared with fresh egg white, the foaming ability of EWP with different freezing times (0, 3, 7, 14, 21 days) after HIUS treatment (20 kHz, 60% amplitude, 5 min) was significantly improved, especially the EWP after 21 days of frozen storage was doubled by HIUS induction. Furthermore, it was found that the improvement of EWP foamability was mainly due to the enhancement of surface hydrophobicity and the decrease of apparent viscosity, which increased the diffusion rate of protein to the interface and its adsorption amount at the interface. These results showed that HIUS was a simple, efficient and residue free way to improve the foam characteristics of frozen EWP, which has strong promotion and application value.
Extension of sectional pseudocomplementation in posets
Authors: Cīrulis Jānis 
Published: August 2022

Abstract
Sectional pseudocomplementation (sp-complementation) on a poset is a partial operation * which associates with every pair (x,y) of elements, where x ≥ y, the pseudocomplement x*y of x in the upper section [y). Any total extension → of * is said to be an extended sp-complementation and is considered as an implication-like operation. Extended sp-complementations have already be studied on semilattices and lattices. We describe several naturally arising classes of general posets with extended sp-complementation, present respective elementary properties of this operation, demonstrate that two other known attempts to isolate particular such classes are in fact not quite correct, and suggest suitable improvements.MSC Classification: 03G25 , 06A99 , 08A99
A study on morphometric features of the distal femoral resected surface in the osteoarthritis knees of Chinese patients and the differences in Males and Females.
Authors: Ke Song , Ran Tianfei , Ma Tianying , Qin Yinyin , Zhang Bokai , Wang Min 
Published: August 2022

Abstract
Purpose
To measure the morphometric features of the distal femoral resected surface in the osteoarthritis knees of Chinese patients and to analyze the morphometric variation of the distal femoral resected surface.
Method
The computer tomography (CT) images of a total of 406 knees from 203 osteoarthritis patients who underwent total knee arthroplasty (TKA) from January 2018 to December 2021 were analyzed. These imaging data were imported into the software of Mimics 21.0 and the three-dimensional (3D) model of the femur was reconstructed. When the distal femoral bone resection was simulated in this software, the measurement of medial-lateral (ML) dimension and anterior-posterior (AP) dimension of the resected surface was performed in the software. We analyzed the differences of AP dimension, ML dimension, and aspect ratio (ML/AP) between females and males.
Result
The mean ML dimension, the mean AP dimension, and the mean AR value measured in Chinese knees were 66.36 ± 4.61 mm, 58.39 ± 3.81 mm, and 1.14 ± 0.07 respectively. An obvious inter-individual morphometric variation of the distal femoral resected surface was observed between males and females. The data of the dimensions for Males are significantly larger than that for females, including the calculated values of AR. The results showed that the distal femoral resected surface of female seemed to be “narrower” than that of male.
Conclusion
The morphology of the distal femoral resected surface in Chinese patients with osteoarthritis shows great interpersonal variability, with men showing significantly higher values than women. Our results could provide a reference for the design of the prosthesis best fit for Chinese.