bluuebunny/crossref_metadata_2025_split huggingface dataset:
The investigation of optical and photocatalytic properties in Dy2M2O7 (M= Hf, Zr and Ce)
Authors: Zaari halima , ouassoul khawla , mezzat fatima zahra , yahyaoui fadwa el , kenz abedllah , abilah benyoussef 
Published: February 2022

Abstract
A great effort has been done to improve the efficiency of materials for photo-catalytic water splitting application. The most famous catalysis is TiO2, but its band gap, exceeds 3.0 eV, doesn’t fit into the visible spectrum. so, to exploit this range of energy, we are looking for other materials having band gap lower that 2.0 eV. The research focused on the enhancement of photo-catalysis by modification of TiO2 by means of metal loading, metal ion doping, …This paper aims to present a group of compounds Dy2M2O7 (with M = Hf, Ce and Zr) which could be an alternative having the same function as TiO2. Based on our studies and those reported in the literature, we will discuss in detail the roles and the functional mechanism of the catalysts. The results show that Zr2Dy2O7 is the best candidate to be a photo-catalyst: it has a band gap close to 2.2 eV, and a good absorption in visible range compared to the other compound having absorption in UV. The quantum efficiency of Zr2Dy2O7 reaches up to 3%, and the limit of conduction band and valence band are localized in potential redox zone. Doping with Cerium gives another energy level which allows to have other optical transitions, improve the absorption and reach the quantum efficiency to 4% in a visible range.
In-situ observation of the effect of the tribofilm growth on scuffing in rolling-sliding contact
Authors: Ueda Mao , Spikes Hugh , Kadiric Amir 
Published: February 2022

Abstract
General reductions in lubricant viscosities in many machine components mean that the role of lubricant additives in forming tribofilms has become increasingly important to provide adequate surface protection against scuffing. However, the relationship between scuffing and the formation and removal of tribofilms has not been systematically demonstrated. In this study a step-sliding speed scuffing test based on contra-rotation using MTM-SLIM and ETM-SLIM has been employed to observe concurrently tribofilm thickness and the onset of scuffing. The initial sliding speed used was found to significantly affect scuffing performance since it determines the extent to which a tribofilm can form before critical sliding speed conditions are reached. Generally, additives that formed thicker tribofilms, especially ZDDPs and triphenyl phosphate, gave effective protection against scuffing, though their protective tribofilms were progressively removed at higher sliding speeds, eventually resulting in scuffing.
Technical and oncological safety of laparoscopic gastrectomy for gastric cancer in elderly patients ≥80 years old
Authors: Ueda Yoshitake , Shiraishi Norio , Fujishima Hajime , Kawasaki Takahide , Ninomiya Shigeo , Shiroshita Hidefumi , Etoh Tsuyoshi , Inomata Masafumi 
Published: February 2022

Abstract
Background: As the incidence of gastric cancer increases in elderly patients worldwide, laparoscopic gastrectomy (LG) for elderly patients with gastric cancer is also increasing. However, whether LG is an optimal surgical modality for elderly patients with gastric cancer remains unclear. This study aimed to evaluate the technical and oncological safety of LG for elderly patients ≥80 years old with gastric cancer.Methods: Patients who received curative gastrectomy for gastric cancer from 2003 to 2015 were enrolled in the study. They were divided into the LG in elderly patients aged over 80 years (LG-E) group, open gastrectomy (OG) in elderly patients (OG-E) group, and LG in non-elderly patients < 80 years (LG-NE) group. Short- and long-term outcomes were compared between the three groups, retrospectively.Results: The LG-E, OG-E, and LG-NE groups comprised 45, 43, and 329 patients, respectively. In the comparison between the LG-E and OG-E groups, the incidence of distal gastrectomy (DG) and the proportions of patients with pathological tumor stage T1, pathological N0, and final stage I were significantly higher in the LG-E versus OG-E group (89 vs. 56%, 76% vs. 16%, 82% vs. 37%, and 84% vs. 35%, p<0.01, respectively). Blood loss and the incidence of overall postoperative complications in the LG-E group were significantly lower than those in the OG-E group (40 vs. 240 g, p<0.01, and 29% vs. 53%, p<0.05, respectively). Although the 5-year overall survival (OS) rate was not significantly different between the two groups, the 5-year disease-specific survival (DSS) rate was significantly higher in the LG-E group versus OG-E group (93% vs. 78%, p<0.05). Overall comorbidities were significantly higher in the LG-E group versus LG-NE group, but there were no significant differences in short-term outcomes between the two groups. Further, although the 5-year OS rate was significantly lower in the LG-E group versus LG-NE group (67% vs. 87%, p<0.01), there was no significant difference between the two groups in 5-year DSS rate.Conclusion: LG is technically and oncologically safe for the treatment of gastric cancer in both elderly patients aged ≥80 years and the non-elderly and can be an optimal surgical modality for elderly patients with gastric cancer.
Omicron BA.2 (B.1.1.529.2): high potential to becoming the next dominating variant
Authors: Chen Jiahui , Wei Guo-Wei 
Published: February 2022

Abstract
The Omicron variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has rapidly replaced the Delta variant as a dominating SARS-CoV-2 variant because of natural selection, which favors the variant with higher infectivity and stronger vaccine breakthrough ability. Omicron has three lineages or subvariants, BA.1 (B.1.1.529.1), BA.2 (B.1.1.529.2), and BA.3 (B.1.1.529.3). Among them, BA.1 is the currently prevailing subvariant. BA.2 shares 32 mutations with BA.1 but has 28 distinct ones. BA.3 shares most of its mutations with BA.1 and BA.2 except for one. BA.2 is found to be able to alarmingly reinfect patients originally infected by Omicron BA.1. An important question is whether BA.2 or BA.3 will become a new dominating ``variant of concern''. Currently, no experimental data has been reported about BA.2 and BA.3. We construct a novel algebraic topology-based deep learning model trained with tens of thousands of mutational and deep mutational data to systematically evaluate BA.2's and BA.3's infectivity, vaccine breakthrough capability, and antibody resistance. Our comparative analysis of all main variants namely, Alpha, Beta, Gamma, Delta, Lambda, Mu, BA.1, BA.2, and BA.3, unveils that BA.2 is about 1.5 and 4.2 times as contagious as BA.1 and Delta, respectively. It is also 30% and 17-fold more capable than BA.1 and Delta, respectively, to escape current vaccines. Therefore, we project that Omicron BA.2 is on its path to becoming the next dominating variant. We forecast that like Omicron BA.1, BA.2 will also seriously compromise most existing mAbs, except for sotrovimab developed by GlaxoSmithKline.
Inflammatory expression profiling defines the tumor microenvironment and immunity in lower-grade gliomas
Authors: Yang Hua , Xiang Xin , Xu Yaka , Zhao Ze-Jing , Peng Han , Chen Yi-Min , Li Wen-Yan , Yang Jie , Qi Xiao-Lan , You Chun-De , Chu Liang-Zhao , Zhou Xing-Wang 
Published: February 2022

Abstract
Objective: Lower-grade glioma (LGG) arises from glial or precursor cells including the world health organization (WHO) grade glioma, which has a favorable prognosis compared with glioblastomas. However, LGG progression is inevitable due to drug resistance and tumor invasiveness. The inflammatory response has been a well-established hallmark associated with tumor occurrence and recurrence. It is necessary to explore the heterogeneity of the inflammatory response in LGG.Methods: The differential and prognostic inflammatory response-related genes(IRRG) of the cancer genome atlas(TCGA) database were used to perform consensus clustering to identify robust clusters. The Chinese Glioma Genome Atlas(CGGA) database was used to validate this inflammation subtype. The clinical characteristics, immune infiltration, metabolism, and somatic variation of each cluster were assessed. A risk score associated with inflammation was constructed.Results: We successfully observed and validated three distinct inflammatory subtypes in LGG. It is noteworthy that the B subtype has a shorter overall survival than the A and C subtypes. The B subtype had higher immune, stromal, and ESTIMATE scores than the A and C subtypes but lower tumor purity than the A and C subtypes. In addition, immune, stromal, and ESTIMATE scores of the A subtype were higher than the hose of the C subtype, while tumor purity was lower than that of the C subtype. Three inflammation subtypes correlated with diverse metabolic characteristics, drug sensitivity, and somatic alterations. Furthermore, we developed and validated an inflammatory signature with better performance of prognosis prediction.Conclusion: This study identified a new classification of LGG according to inflammatory gene profiling and emphasized inflammatory heterogeneity within LGG.
Research on the damage pattern and mechanism of ice wedge saturated coal rock joint structure
Authors: Li Hewan , Sun Siyang , Wang Laigui , Liu Jian , Zhang Ziheng 
Published: February 2022

Abstract
The width and connectivity of the coal rock joints directly affect the percolation capacity of mobile energy sources such as gas. In order to study the damage pattern and mechanism of coal rock joints under the action of liquid nitrogen, two methods, liquid nitrogen-free loading and liquid nitrogen freeze-thawing, were used to modify the damage of joints in coal rocks with different water saturation. The OLS4000 laser confocal microscope and MH-25 universal tensile tester were used to observe the changes in surface joint width and Young's modulus of coal rock before and after the test, and to analyze the effect of ice wedge expansion stress on structural damage of coal rock by building a physical and mechanical model. The test results found that the ice wedge expansion stress in the joints, the surrounding pressure and the temperature stress together affect the structural damage of the coal rock joints, with the ice wedge expansion stress contributing the most. The damage to the coal rock joints increases with increasing water saturation, with the most pronounced damage to the coal rock joints being caused by ice wedge expansion stresses at water saturation. The physical and mechanical model of coal rock joints under load reveals the damage mechanism of coal rock joints affected by ice wedge expansion stress, and establishes damage criteria to provide new ideas for the exploitation of clean energy such as coal bed methane and prevention of impact ground pressure.
Immunomolecular Assay Based on Selective Virion Capture by Spike Antibody and Viral Nucleic Acid Amplification for Detecting Intact SARS-CoV-2 Particles
Authors: Wu Xiaoli , Liu Junye , Zhang Hongpeng , Zhou Hua , Wang Wen , Ma Yuanyan , Shen Shimei , Cai Xuefei , Huang Ailong , Ding Shijia , Wang Deqiang 
Published: February 2022

Abstract
Background: Effective therapeutics and vaccines for coronavirus disease 2019 (COVID-19) are currently lacking because of the mutation and immune escape of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Based on the propagation characteristics of SARS-CoV-2, rapid and accurate detection of complete virions from clinical samples and the environment is critical for assessing infection risk and containing further COVID-19 outbreaks. However, currently applicable methods cannot achieve large-scale clinical application because of factors such as the high viral load, cumbersome virus isolation steps, demanding environmental conditions, and long experimental periods. In this study, we developed an immunomolecular detection method combining capture of the viral spike glycoprotein with monoclonal antibodies and nucleic acid amplification via quantitative reverse transcription PCR to rapidly and accurately detect complete virions.Results: After constructing a novel pseudovirus, screening for specific antibodies, and optimizing the detection parameters, the assay achieved a limit of detection of 9 × 102 transduction units/mL of viral titer with high confidence (~95%) and excellent stability against human serum and common virus/pseudovirus. The coefficients of variation were 1.0–2.0% for intra-assay and inter-assay analyses, respectively. Compared with reverse transcription-PCR, the immunomolecular method more accurately quantified complete virions. SARS-CoV-2/pseudovirus was more stable on plastic and paper than on aluminum and copper in the detection of SARS-CoV-2 pseudovirus under different conditions, and complete virions were detected up to 96 h after they were applied to these surfaces (except for copper), although the titer of the virions was greatly reduced. Conclusions: Convenient, inexpensive, and accurate complete virus detection can be applied in many fields, such as monitoring the infectivity of convalescent and post-discharge patients and assessing high-risk environments (isolation rooms, operating rooms, patient living environments, and cold chain logistics). This method can also be used to detect intact virions such as those of hepatitis B and C viruses, human immunodeficiency virus, influenza, and the partial pulmonary virus, which may further improve the accuracy of diagnoses and facilitate individualized and precise treatments.
Atypical primary biliary cholangitis results in Vanishing bile duct syndrome with cutaneous xanthomas:A case report
Authors: Jia Yuebo , Zhao Jiaqi , Liu Lin , Bai Guang 
Published: February 2022

Abstract
BACKGROUNDVanishing bile duct syndrome (VBDS) is a rare but potentially severe acquired chronic cholestatic liver disease. Bile duct deficiency is a reduction of bile ducts in the liver, which can eventually lead to cholestatic liver disease and progress to biliary cirrhosis. Primary biliary cholangitis (PBC) is one of the causes of bile duct deficiency. In addition, 75% of PBC patients may have dyslipidemia, and in case of secondary dyslipidemia, cutaneous xanthomas may occur.CASE SUMMARYA 49-year-old woman was admitted with jaundice and multiple subcutaneous nodules. She received diagnosis of autoimmune liver disease 2 years before. Although she was treated with liver-protecting drugs, such as Essentiale and ursodeoxycholic acid, jaundice occurred repeatedly, and the color of her skin was becoming darker and more yellow.CONCLUSIONThis case highlights that the positivity of ANA that in PBC have a well diagnostic and prognostic significance and antinuclear antibodies giving the 'multiple nuclear dots' or the 'rim-like/membranous' pattern scan ca diagnose primary biliary cirrhosis accurately. Since the liver biopsy of PBC alone may not be sufficient to establish the diagnosis, serum antibodies should also be examined. PBC can also lead to intrahepatic cholestasis, which can cause dyslipidemia and cutaneous xanthomas.
Androgen Receptor Reprogramming Demarcates Prognostic Gene Sets In Prostate Cancer
Authors: Severson Tesa , Qiu Xintao , Alshalalfa Mohammed , Sjöström Martin , Bergman Andries , Long Henry , Feng Felix , Freedman Matthew L. , Zwart Wilbert , Pomerantz Mark M. 
Published: February 2022

Abstract
The androgen receptor (AR) is a prostate master transcription factor. It binds to genetic enhancers, where it regulates gene activity and plays a fundamental role in prostate pathophysiology. Previous work has demonstrated AR-DNA binding is systematically and consistently reprogrammed during prostate tumorigenesis and disease progression. We charted these reprogrammed AR sites and identified genes proximal to them. We were able to devise gene lists based on AR status within specific histological contexts: normal prostate epithelium, primary prostate tumor, and metastatic prostate cancer. We evaluated expression of the genes in these gene sets in subjects from two distinct clinical cohorts – men treated with surgery for localized prostate cancer and men with metastatic prostate cancer. Among men with localized prostate cancer, expression of genes proximal to AR sites lost in the transition from normal prostate to prostate tumor was associated with clinical outcome. Among men with metastatic disease, expression of genes proximal to AR sites gained in metastatic tumors were associated with clinical outcome. The study demonstrates the power of incorporating context-dependent epigenetic data into genetic analyses.
3D Printing For Surgical Planning Of Canine Oral And Maxillofacial Surgeries
Authors: Huang Yu-Hui , Lee Bonnie , Chuy Jeffrey , Goldschmidt Stephanie 
Published: February 2022

Abstract
Background: Advanced diagnostic imaging is an essential part of preoperative planning in oral and maxillofacial surgery in veterinary patients. 3D printed model and surgical guide generated from diagnostic imaging can provide a deeper understanding of the complex maxillofacial anatomy and relevant spatial relationships. Additionally, patient-specific 3D printed models allow surgeons and trainees to better examine anatomical features through tactile and visual spatial feedback resulting in improved preoperative planning and enhanced trainee education.Case presentation: Our case series consists of three 3D printed models segmented from computed tomography (CT) and cone beam CT (CBCT) and fabricated via desktop vat polymerization for preoperative planning and intraoperative guidance for resection of maxillary osteosarcoma, mandibular reconstruction after mandibulectomy, and gap arthroplasty for temporomandibular joint ankylosis in dogs.Conclusions: We illustrate potential benefits and indications for 3D printing in veterinary oral and maxillofacial surgery. A 3D printed model facilitates the understanding of complex surgical anatomy and creates an opportunity to assess the spatial relationship of complex anatomical structures. The patient-specific 3D model facilitates individualized surgical planning allowing surgeons to tailor and augment the surgical plan by identifying challenging anatomy and simulating surgical steps in advance. This includes the planning of osteotomy lines and pre-contouring of titanium plates for reconstruction. The 3D printed model and surgical guide also serve as intraoperative reference and guidance. In addition to preoperative planning and intraoperative guidance, 3D printed models have the potential to improve veterinary resident and student training as well as pet owners’ understanding and communication regarding the condition of their pets, treatment plan and intended outcomes.
Total Laparoscopic Pancreaticoduodenectomy with Left Posterior Superior Mesenteric Artery First-Approach and Plexus-Preserving Circumferential Lymphadenectomy: A Surgical Case Report (With Video)
Authors: NGUYEN Thanh Khiem , NGUYEN Ham Hoi , LUONG Tuan Hiep , DANG Kim Khue , LE Van Duy , Inoue Yosuke , TRINH Hong Son , TRAN Duc Dung 
Published: February 2022

Abstract
Introduction:
Total laparoscopic pancreaticoduodenectomy (tLPD) for cancer of Vater remains a challenging procedure. Recently, several meta-analyses showed the superior aspects of “Superior Mesenteric Artery (SMA)-first approach”, “Systematic mesopanreas dissection” and “Circumferential lymphadenectomy around SMA” in increasing R0-resection rate and reducing postoperative complications including pancreatic fistula and bleeding as well as improving overall survival particularly.
Case presentation:
Our patient is a 70-year-old female with a no special medical history, recruited because of jaundice. She was referred for pancreaticoduodenectomy because of a 10mm-sized mass in distal bile duct referred to Vater’s tumor. We use 5 trocars and the patient placed in a Trendelenburg position. The transverse colon was lifted, the first loop of the jejunum was pulled to the left, the lymph nodes groups 14th and 15th were removed en bloc and then exposed the SMA from the anterior to the left posterior side from the caudal side to the origin. The first jejunal vessels and the posterior inferior pancreaticoduodenal artery were ligated and extensive mobility of the duodenum and head of the pancreas from the left side. The systematic mesopancreas dissection from the right site of the SMA will be easily and conveniently done afterwards. Histopathological examination of ypT2N1 indicated that 1 of the 22 lymph nodes was positive, that was 1 of 7 LNs No. 14. Pathological results showed a Vater adenocarcinoma with all margins being negative.
Conclusions
This technique was safe and effective to perform precise level-2 mesopancreas dissection and complete lymphadenectomy around SMA without dissection of pl-SMA in laparoscopic field.
Primary Chemotherapy Resistance Malignant Mural Nodules Originated from Mucinous Borderline Ovarian Tumor: A Rare Case Report
Authors: Purbadi Sigit , Tjahjadi Hartono , Tjokroprawiro Brahmana Askandar , Purwoto Gatot , Winarto Hariyono , Sotarduga Gilbert Elia , Scovani Laurensia 
Published: February 2022

Abstract
BackgroundThe borderline ovarian mucinous cystic tumor may appear with mural nodules. However, its entity may remain rare. Malignant mural nodules mainly occur in old patients and have poor clinical outcomes. Accurate diagnosis of mural nodules is vital to choose the proper treatment, although it is complicated to manage.Case PresentationA 24-years-old nulliparous woman was examined due to abdominal pain and enlargement. She had been performed salpingo-oophorectomy due to ovarian tumor suspicion in the previous hospital. We did the surgical staging and found severe adhesion, but no cancer cell was found. During the follow-up, the symptoms got worsened. The CT-Scan results said massive ascites, CA 125 levels raise to 174 U/mL, and CA 19-9 920 U/mL. Exploratory laparotomy was performed, histology examination concluded malignant mural nodules mixed type on an ovarian borderline mucinous tumor. Carboplatin 750mg, paclitaxel 300mg, and bevacizumab 800mg was prescribed. In the beginning, the response was great, CA 125 and CA 19-9 levels decreased. But after four cycles, the CA 19-9 levels raise significantly. On the other hand, the CA 125 remains normal. We concluded that it was a chemotherapy resistance – malignant mural nodules and new chemotherapy regiment was prescribed but also resistance. Currently, the patient refused to continue the treatment.ConclusionAlthough it is rare, malignant mural nodules should be considered when we find a mucinous borderline ovarian tumor at a younger age. The angiosarcoma-type mural nodule is very difficult to manage due to the high probability of chemotherapy resistance.
Beneficial of adding Tocilizumab to standard care in critical forms of Covid-19: Study on paired series
Authors: Trifi Ahlem , Abdennebi Cyrine , Romdhane Kais Ben , Blel Youssef , Daly Foued , Zakhama Boubaker , Mestiri Taher , Abdellatif Sami , Lakhal Salah Ben 
Published: February 2022

Abstract
We designed a comparative study on two paired series of critical patients affected with Covid-19: the 1st group received Tocilizumab (TCZ) plus standard care (SC) versus a 2nd group which received only SC. Outcomes were: survival, mechanical ventilation (MV) and nosocomial infections. Ninety patients were included by pairing (n=45 in each group). 55.5% of SC group progressed to stage 3-acute respiratory distress syndrome (ARDS) versus 31% of TCZ+SC patients (p=0.03). No effect of TCZ was found on mortality (49% in each group, p=1) nor on MV use (p=0.67). ICU stay was more prolonged in TCZ+SC group (16 versus 8 days, p <10-3). The administration of TCZ induced a significant decrease in CRP but not changed the IL-6 dosage. Nosocomial infections occurred in 18 (40%) of TCZ+SC group comparatively to 15 (33,5%) of SC group, p=0.66. We concluded to no real clinical impact benefit of TCZ in this kind of patients.