bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical study of ganshuang granule combined with tenofovir in the treatment of chronic hepatitis B complicated with nonalcoholic fatty liver disease
Authors: Su Changtian , Yang Qin 
Published: December 2022

Objective: This study aims to investigate the clinical efficacy of Ganshuang granules combined with tenofovir, an antiviral drug, in the treatment of chronic hepatitis B complicated with nonalcoholic fatty liver disease.Methods: A total of 92 patients with chronic hepatitis B combined with non-alcoholic fatty liver who were treated in our Hospital from January 2020 to December 2021 were included as the research objects. According to the method of random number table, the patients were divided into the control group (n = 42) and the treatment group (n = 50). The control group was treated with silibinin meglumine tablets and tenofovir, while the treatment group was treated with Ganshuang granules combined with silybin meglumine tablets and tenofovir. Before and after treatment, liver function index, liver hardness measurement (LSM), controlled attenuation parameter (CAP), HBV-DNA serum load and body mass index (BMI) were observed.Results: Compared with the baseline, ALT, AST and GGT were significantly improved in both groups after treatment (p &lt; 0.05), while TBIL indexes were not significantly different before and after treatment (p &gt; 0.05). Patients in the treatment group had significantly lower ALT and AST index values than the control group at 12 and 24 weeks of treatment (p &lt; 0.05). At 12 and 24 weeks of treatment, the fat attenuation parameters of the two groups were significantly decreased compared with those before treatment, and the difference was statistically significant (p &lt; 0.05). The fat attenuation parameters in the treatment group were significantly lower than those in the control group at 12 and 24 weeks after treatment (p &lt; 0.05).Conclusion: The effect of Ganshuang granule combined with antiviral drugs in the treatment of chronic hepatitis B complicated with non-alcoholic fatty liver is significantly better than that of antiviral drugs alone, which is worthy of clinical recommendation.Systematic Review Registration:https://register.clinicaltrials.gov, identifier NCT05523648.
The use of non-linear tools to analyze the variability of force production as an index of fatigue: A systematic review
Authors: García-Aguilar Fernando , Caballero Carla , Sabido Rafael , Moreno Francisco J. 
Published: December 2022

Background: Fatigue is a process that results in a decreased ability to produce force, and which could eventually affect performance and increase the risk of injury. Force variability analysis has been proposed to describe the level of fatigue with the purpose of detecting the development of fatigue. Variability is credited to play a functional and adaptive role through which the components of a system self-organize to solve a motor problem. Non-linear tools have been applied to analyze the variability of physiological signals, revealing that the structure of motor fluctuations provides relevant information about the functional role of variability. It has been suggested that the presence of lower complexity in the variability structure could reveal a less functional and adaptative state (e.g., ageing or illness). In the last years, an increased number of studies have applied these techniques to force variability analysis in relation to fatigue.Objective: To provide an overview of the current knowledge on the use of non-linear tools on force variability as a fatigue index.Methods: Following PRISMA guidelines, a systematic search of SPORTDiscus, Scopus, Web of Science and PubMed was carried out. Studies included were: a) original studies that analyzed the effect of fatigue on humans during an action focused on force production; b) published studies with their title and abstract in English; c) studies that applied non-linear tools on a signal directly related to force production.Results: Twenty-five studies were included in this review. The relationship between fatigue and the complexity of force variability, the type of action and relative intensity, the nature of the signal and the non-linear tools used, and the methods of data acquisition and processing were identified.Conclusion: The articles reviewed suggest that fatigue leads to a decrease in complexity mostly in isometric contractions, but this is not as clear in dynamic contractions. This fatigue-induced loss of complexity seems to be a result of changes in the nervous system at the central level, albeit triggered by peripheral mechanisms. It should be noted that non-linear tools are affected by the relative intensity of contraction, non-stationarity, and the acquisition and treatment of the signal.
The power of transfer learning in agricultural applications: AgriNet
Authors: Al Sahili Zahraa , Awad Mariette 
Published: December 2022

Advances in deep learning and transfer learning have paved the way for various automation classification tasks in agriculture, including plant diseases, pests, weeds, and plant species detection. However, agriculture automation still faces various challenges, such as the limited size of datasets and the absence of plant-domain-specific pretrained models. Domain specific pretrained models have shown state of art performance in various computer vision tasks including face recognition and medical imaging diagnosis. In this paper, we propose AgriNet dataset, a collection of 160k agricultural images from more than 19 geographical locations, several images captioning devices, and more than 423 classes of plant species and diseases. We also introduce AgriNet models, a set of pretrained models on five ImageNet architectures: VGG16, VGG19, Inception-v3, InceptionResNet-v2, and Xception. AgriNet-VGG19 achieved the highest classification accuracy of 94% and the highest F1-score of 92%. Additionally, all proposed models were found to accurately classify the 423 classes of plant species, diseases, pests, and weeds with a minimum accuracy of 87% for the Inception-v3 model. Finally, experiments to evaluate of superiority of AgriNet models compared to ImageNet models were conducted on two external datasets: pest and plant diseases dataset from Bangladesh and a plant diseases dataset from Kashmir.
Case report: Amisulpride therapy induced reversible elevation of creatine kinase-MB and bradycardia in schizophrenia
Authors: Hu Ze-Rui , Yang Zhen-Zhen , Wang Xu-Bo , Chu Hong-Shuo , Liu Chuan-Xin 
Published: December 2022

IntroductionSchizophrenia is regarded as one of the most severe, disabling, and costly mental illnesses. Hence, early effective prevention and treatment are critical to the prognosis of patients. Amisulpride, a first-line atypical antipsychotic medication that acts as a blocker of the D2 and D3 dopamine receptors, is used in varying doses for the treatment of both positive and negative symptoms of schizophrenia. Reversible amisulpride-induced elevation of the myocardial enzyme spectrum with bradycardia is a rare condition.Case presentationWe report a 26-year-old patient diagnosed with first-episode schizophrenia. This patient was treated with amisulpride (400 mg/d), but no clinical benefits were obtained. Meanwhile, amisulpride caused elevation of the myocardial enzyme spectrum with asymptomatic bradycardia. After stopping the medication, these parameters normalized.ConclusionWe described a rare side reaction of amisulpride. Psychiatrists should take this side effect seriously in the clinical setting. The mechanism of this adverse reaction warrants further investigation and debate. When this side effect occurs during treatment, reducing the dosage of amisulpride and subsequently discontinuing medication, along with monitoring the electrocardiogram and serum myocardial enzymes, may be the most appropriate treatment protocol.
Social participation and mental health of immunocompromised individuals before and after COVID-19 vaccination–Results of a longitudinal observational study over three time points
Authors: Heesen Gloria , Heinemann Stephanie , Müller Frank , Dopfer-Jablonka Alexandra , Mikuteit Marie , Niewolik Jacqueline , Klawonn Frank , Vahldiek Kai , Hummers Eva , Schröder Dominik 
Published: December 2022

IntroductionThe coronavirus disease 2019 (COVID-19) pandemic impacted how people perform their daily lives in manifold and sometimes massive ways. Particularly, individuals who are at high risk for a severe disease progression, like immunocompromised people, may have experienced drastic changes in social participation during the pandemic. A COVID-19 basic vaccination may have changed the safety behavior of immunocompromised individuals in terms of infection risk and thereby influence social participation and mental wellbeing.MethodsThis study aims to investigate self-perceived social participation at baseline before and at follow-up 1 and 6 months after basic vaccination. Beginning in March 2021, 274 immunocompromised persons 18 years or older were enrolled in the COVID-19 Contact Immune study (CoCo study) in Lower Saxony, Germany. Measurements were performed at three time points regarding social participation [Index for the Assessment of Health Impairments (IMET)], mental health [Patient Health Questionnaire-4 (PHQ-4)], subjective health status (five-point Likert-scale) and quality of life (five-point Likert-scale).ResultsIn total, 126 participants were included in the final analysis. About 60% of the participants showed increasing social participation over time. The greatest increase in social participation was observed within the first month after basic vaccination (p &lt; 0.001). During the following 5 months, social participation remained stable. The domains “social activities,” “recreation and leisure” and “close personal relationships” were responsible for the overall change in social participation. No association was found between social participation and mental health, sociodemographic or medical factors (except hypertension).DiscussionIt is unclear why social participation increased after basic vaccination. Perceived vaccine efficacy and a feeling of being protected by the vaccine may have caused relaxed social distancing behaviors. Reducing safety behaviors may, however, increase the risk of a COVID-19 infection for immunocompromised individuals. Further investigations are needed to explore the health-related consequences of more social participation among immunocompromised persons.
Regional surveillance of medically-attended farm-related injuries in children and adolescents
Authors: VanWormer Jeffrey J. , Berg Richard L. , Burke Richard R. , Barnes Kathrine L. , Weichelt Bryan P. 
Published: December 2022

PurposeDue to numerous environmental hazards such as heavy machinery and large livestock, youth who live and work on farms are at high risk of injury, disability, and death. This study described a regional surveillance system for monitoring farm-related injuries in children and adolescents. As the risk of farm-related injuries are not exclusive to farm residents, trends in farm-related injuries over the previous 5 years were reported and compared between children/adolescents who did and did not live on farms in north-central Wisconsin.MethodsA retrospective cohort of child and adolescent patients of the Marshfield Clinic Health System was assembled. Incident farm-related injuries, including from agricultural work or other activities in a farm environment, were extracted from medical records from 2017 through 2021. Generalized linear models were created to compare age- and sex-adjusted farm-related injury rates by year.ResultsThere were 4,730 (5%) in-farm and 93,420 (95%) out-farm children and adolescents in the cohort. There were 65 incident farm-related injury cases in the in-farm group and 412 in the out-farm group. The annual incidence rate of farm-related injuries was higher in the in-farm group, but changes during the 5-year timeframe were not significant in either group. In the in-farm group, rates ranged from a high of 61.8 [95% confidence interval (CI): 38.3, 94.5] incident farm-related injuries per 10,000 children/adolescents in 2017 to a low of 28.2 (13.5, 51.9) injuries per 10,000 children/adolescents in 2018. In the out-farm group, rates ranged from 10.7 (8.3, 13.6) to 16.8 (13.7, 20.5) incident farm-related injuries per 10,000 children/adolescents per year between 2017 and 2021. The in-farm group had a higher proportion of injured males and heavy machinery injuries, while the out-farm group had more all-terrain vehicle injuries and pesticide poisonings.ConclusionFarm residency remains hazardous for children and adolescents, as injury rates were three times higher in the in-farm group and remained stable over 5 years. All-terrain vehicle injuries were high in both groups, and should be a priority in rural safety interventions. With additional adaptations to other states, this surveillance model could be scaled across other healthcare systems.
SARS-CoV-2 infections among asymptomatic individuals contributed to COVID-19 cases: A cross-sectional study among prospective air travelers from Ghana
Authors: Akowuah Kwasi A. , Akuffo Richard A. , Boateng Anthony T. , Asigbee Theodore W. , Bonney Joseph H. K. , Lamptey Helena , Adusei-Poku Mildred A. , Obodai Evangeline , Asante Ivy A. , Adjei Samuel , Aboagye James O. , Adu-Amankwah Susan , Partey Frederica D. , Kyei George B. , Ampofo William K. , Odoom John K. , Bonney Evelyn Y. 
Published: December 2022

BackgroundThe spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) by asymptomatic individuals has been reported since the early stages of the coronavirus disease 2019 (COVID-19) outbreak in various parts of the world. However, there are limited data regarding SARS-CoV-2 among asymptomatic individuals in Ghana. The aim of the study was to use test data of prospective travelers from Ghana as a proxy to estimate the contribution of asymptomatic cases to the spread of COVID-19.MethodsThe study analyzed the SARS-CoV-2 PCR test data of clients whose purpose for testing was classified as “Travel” at the COVID-19 walk-in test center of the Noguchi Memorial Institute for Medical Research (NMIMR) from July 2020 to July 2021. These individuals requesting tests for travel generally had no clinical symptoms of COVID-19 at the time of testing. Data were processed and analyzed using Microsoft Excel office 16 and STATA version 16. Descriptive statistics were used to summarize data on test and demographic characteristics.ResultsOut of 42,997 samples tested at the center within that period, 28,384 (66.0%) were classified as “Travel” tests. Of these, 1,900 (6.7%) tested positive for SARS-CoV-2. The majority (64.8%) of the “Travel” tests were requested by men. The men recorded a SARS-CoV-2 positivity of 6.9% compared to the 6.4% observed among women. Test requests for SARS-CoV-2 were received from all regions of Ghana, with a majority (83.3%) received from the Greater Accra Region. Although the Eastern region recorded the highest SARS-CoV-2 positivity rate of 8.35%, the Greater Accra region contributed 81% to the total number of SARS-CoV-2 positive cases detected within the period of study.ConclusionOur study found substantial SARS-CoV-2 positivity among asymptomatic individuals who, without the requirement for a negative SARS-CoV-2 result for travel, would have no reason to test. These asymptomatic SARS-CoV-2-infected individuals could have traveled to other countries and unintentionally spread the virus. Our findings call for enhanced tracing and testing of asymptomatic contacts of individuals who tested positive for SARS-CoV-2.
Development of three new multidimensional measures to assess household food insecurity resilience in the United States
Authors: Calloway Eric E. , Carpenter Leah R. , Gargano Tony , Sharp Julia L. , Yaroch Amy L. 
Published: December 2022

IntroductionThis study aimed to develop and test novel self-administered measures (Absorptive capacity, Adaptive capacity, and Transformative capacity) of three aspects of a household's resilience to financial shocks (e.g., job loss) that can increase food insecurity risk.MethodsMeasures were piloted in a convenience sample of households at risk for food insecurity in the United States. The survey included the new measures, validation variables (financial shock, household food security, general health, personal resilience to challenges, and financial wellbeing), and demographic questions. Exploratory factor analysis was used to assess dimensionality, internal consistency was assessed [Cronbach's alpha (CA)], and construct validity was assessed (Spearman's correlation). Also, brief screener versions of the full measures were created.ResultsParticipants in the analytic samples (n = 220-394) averaged 44 years old, 67% experienced food insecurity, 47% had a high school diploma or less, 72% were women, and the sample was racially/ethnically diverse. Scores for Absorptive capacity [one factor; CA = 0.70; Mean = 1.32 (SD = 0.54)], Adaptive capacity [three factors; CAs 0.83-0.90; Mean = 2.63 (SD = 0.85)], and Transformative capacity [three factors; CAs 0.87-0.95; Mean = 2.70 (SD = 1.10)] were negatively associated with financial shocks (−0.221 to −0.307) and positively associated with food insecurity (0.310-0.550) general health (0.255-0.320), personal resilience (0.231-0.384), and financial wellbeing (0.401-0.474).DiscussionThese findings are encouraging and support reliability and validity of these new measures within this sample. Following further testing, such as Confirmatory Factor Analysis in future samples, these measures may prove useful for needs assessments, program evaluation, intake screening, and research/surveillance. Widespread adoption in the future may promote a more comprehensive understanding of the food insecurity experience and facilitate development of tailored interventions on upstream causes of food insecurity.
Politics of hesitance and the formation of ethical subjects through responsible gambling practices
Authors: Selin Jani 
Published: December 2022

IntroductionInstead of harm prevention and risk related to gambling products, responsible gambling discourse emphasizes the importance of voluntary measures. From the point of view of governmentality, the responsible gambling practices produce, rely on, and call forth subjectivities. The aim of the study is to find out what kind of subjects are being produced through the responsible gambling practices of four Nordic state-owned gambling companies. As the companies are state-owned and operate on different types of markets, there are reasons to suspect that the companies could endorse different versions of the figure of responsible gambler. Previous research indicates that responsible gambling practices typically presuppose or aim to produce a self-governing subject making informed choices. Less attention has been given to detailed analyses of the heterogeneous factors contributing to the ethical subject formation. Moreover, there is a growing body of literature indicating, that along with the use of detailed behavioral data (big data), new forms of governmentality, that are highly relevant from the point of view of subject formation, are emerging.MethodsThe responsible gambling practices are analyzed along Michel Foucault's four aspects of ethics. First, there is ethical substance, the problematic aspect of the self that is taken as the target of the ethical work. Second, the subject needs to have a certain relation to social norms and moral codes. Third, ethical work is needed to mold the problematic aspect of the self. Fourth, the aim of the ethical work is a certain mode of being or relationship to oneself. The analyzed material consists of the annual reports of the companies between 2019 and 2021.Results and discussionThe results show that the figure of subject making informed voluntary choices is deeply embedded in the responsible gambling practices of the companies. The companies entice the gamblers to think about themselves and to act upon themselves as subjects capable of self-control. Hesitancy to intervene characterizes the activities of the companies, even if all the companies collect and use detailed behavioral data. The inclusion of the precarious subject of gambling harm would allow the companies to do much more to prevent gambling harm.
The Lompe code: A Python toolbox for ionospheric data analysis
Authors: Hovland A. Ø. , Laundal K. M. , Reistad J. P. , Hatch S. M. , Walker S. J. , Madelaire M. , Ohma A. 
Published: December 2022

A recent paper by Laundal et al. (2022c) presented a new technique to combine all available measurements of polar ionospheric electrodynamics; magnetic field measurements from ground and space, ionospheric convection data from radars and satellites, and conductance measurements; to a full 2D map within analysis regions of arbitrary resolution and extent. The technique, called Local Mapping of Polar Ionospheric Electrodynamics (Lompe), is implemented in Python (Laundal et al., 2022a). The Lompe technique combines spherical elementary current system analysis, finite element analysis on a cubed-sphere projection, the use of empirical models like the International Geomagnetic Reference Field, and visualization tools. In this paper, we go through these different components of the Lompe code and show how they are useful on their own, for example in the analysis of ground magnetometer data or data from the upcoming Electrojet Zeeman Imaging Explorer mission. We also demonstrate how to use the Lompe code to produce a coherent picture of ionospheric electrodynamics.
Parthenolide induces rapid thiol oxidation that leads to ferroptosis in hepatocellular carcinoma cells
Authors: LoBianco Francesca V. , Krager Kimberly J. , Johnson Erica , Godwin Christopher O. , Allen Antino R. , Crooks Peter A. , Compadre Cesar M. , Borrelli Michael J. , Aykin-Burns Nukhet 
Published: December 2022

Hepatocellular carcinoma (HCC) is both a devastating and common disease. Every year in the United States, about 24,500 men and 10,000 women are diagnosed with HCC, and more than half of those diagnosed patients die from this disease. Thus far, conventional therapeutics have not been successful for patients with HCC due to various underlying comorbidities. Poor survival rate and high incidence of recurrence after therapy indicate that the differences between the redox environments of normal surrounding liver and HCC are valuable targets to improve treatment efficacy. Parthenolide (PTL) is a naturally found therapeutic with anti-cancer and anti-inflammatory properties. PTL can alter HCC’s antioxidant environment through thiol modifications leaving tumor cells sensitive to elevated reactive oxygen species (ROS). Investigating the link between altered thiol mechanism and increased sensitivity to iron-mediated lipid peroxidation will allow for improved treatment of HCC. HepG2 (human) and McARH7777 (rat) HCC cells treated with PTL with increasing concentrations decrease cell viability and clonogenic efficiency in vitro. PTL increases glutathione (GSH) oxidation rescued by the addition of a GSH precursor, N-acetylcysteine (NAC). In addition, this elevation in thiol oxidation results in an overall increase in mitochondrial dysfunction. To elucidate if cell death is through lipid peroxidation, using a lipid peroxidation sensor indicated PTL increases lipid oxidation levels after 6 h. Additionally, western blotting reveals glutathione peroxidase 4 (GPx4) protein levels decrease after treatment with PTL suggesting cells are incapable of preventing lipid peroxidation after exposure to PTL. An elevation in lipid peroxidation will lead to a form of cell death known as ferroptosis. To further establish ferroptosis as a critical mechanism of death for HCC in vitro, the addition of ferrostatin-1 combined with PTL demonstrates a partial recovery in a colony survival assay. This study reveals that PTL can induce tumor cell death through elevations in intracellular oxidation, leaving cells sensitive to ferroptosis.