bluuebunny/crossref_metadata_2025_split huggingface dataset:
Use of the Superblock Model for Physical Activity in Barcelona: A one-year observational comparative study using SOPARC
Authors: Puig-Ribera Anna , Arumí-Prat Ignasi , Cirera Eva , Solà Marta , Codina Anna , Palència Laia , Biaani Brenda , Pérez Katherine 
Published: August 2022

Abstract
Background: The Barcelona Superblock model transforms urban public spaces into active-friendly spaces, a key issue for public health. This study assessed the use of a newly developed Superblock in St. Antoni Market Square for physical activity and sedentary behaviour during the first year of implementation. It then compared citizens’ use of the Superblock for physical activity and sedentary behaviour with a comparison site at one-year follow-up, when the Superblock was fully integrated into citizens’ daily life. Methods: This observational comparative study (May 2018-May 2019) used the System for Observing Play and Recreation in Communities (SOPARC). SOPARC assessed citizens’ sitting, standing, walking, vigorous activities and use of electric scooter by gender, age group and time of the day. At the Superblock site, two observers completed five weekly observations: the opening week, and at three, five, eight and twelve months. At the comparison site, observers completed one weekly observation at twelve months after the implementation of the Superblock. Observations included 4 days/week (including weekends) and, 4 hours/day (morning, midday, afternoon, evening). Results: At baseline, an average of 2,340 citizens/hour were observed using the Superblock but visits reduced by 12% in the next three observation weeks and 17.6% after one-year (mainly elderly and teenagers). At baseline, 92.9% walked in the Superblock, while 3.1% engaged in vigorous physical activity. After one year, citizens’ walking decreased by 18.2%, from 2,170 citizens/hour at baseline to 1,930 citizens/hour. Citizens’ engagement in vigorous activities also declined by 11%, from 73 citizens/hour at baseline to 65 citizens/hour at one-year follow up. In the comparison site, citizens’ usage for walking and vigorous physical activity was similar to the Superblock. Conclusions: This is the first study to assess citizens’ usage for physical activity of the Barcelona Superblock model, an urban built-environment intervention that is both novel and health-enhancing. The Superblock model would benefit from strategies maximizing effectiveness for promoting superblock-based physical activity, with special focus on seniors and teenagers.
Assessment of the Quality of Economic Growth in Agriculture
Authors: Abduvakhidov Akmal , Eshpulatov Dostonbek , Olimovna Kadyrova Dilafruz 
Published: August 2022

Abstract
The issue of economic growth is one of the main macroeconomic problems that have always been of interest to economists. Also, in the current macroeconomic situation, another side of the problem is being manifested. That is, the current issue is not only economic growth, but also the study of the factors that determine its quality has become an urgent issue. The existing theories of economic growth cannot fully explain the matter. Therefore, the article studied the issues of qualitative economic growth and evaluated statistical indicators that determine it. Indicators such as material return, capital return and labor productivity were selected as the main indicators that ensure the quality of economic growth in agriculture. Conducting the research, we found out that the indicator of material return and capital return in agriculture has been decreasing. Moreover, the exact conclusions and suggestions were made on ensuring quality economic growth in agriculture.
Comparison of Clinical and Radiological Outcome of Radial Shortening and Capitate Shortening in the Early Stages of Kienböck Disease
Authors: Nazari Dariush , Kachooei Amir R. , Rezaeian Amin , Birjandinejad Ali , Ariamanesh Amir Shahriar , Moradi Ali 
Published: August 2022

Abstract
Background: This study aims to compare the clinical and radiological outcomes of radial shortening osteotomy (RSO) and capitate shortening osteotomy (CSO) in the early stages of Kienböck disease. Methods: Grip strength and wrist range of motion were assessed bilaterally. Also, the disease stage in pre-op and the final follow-up were determined. Quick-DASH, Patient-Rated Wrist Evaluation (PRWE), and Modified Mayo Wrist Score were used to assess patient comfort and function.Results: 23 patients were followed up (13 patients with RSO and 10 patients with CSO) for mean 46 months. Affected wrist range of motion in flexion and extension and grip strength was significantly lower than the unaffected side. Pain score in the Mayo wrist questionnaire was significantly lower in the RSO group than CSO group. The failure rate was 1.16% and 2.59% per year for RSO and CSO, respectively. Radiologic stage worsened in two patients (one in each RSO and CSO groups) and it was improved in nine patients (six in RSO and three in CSO groups). Six patients (three in each RSO and CSO groups) underwent revision surgeries due to residual pain. As expected, wrist motion arc and grip strength were significantly more limited in these patients in comparison to others (p=0.031 and p=0.026, respectively).Conclusion: We found no significant differences between the two groups in terms of clinical findings, patients’ function and satisfaction, and success rate. Level of evidence: III - Retrospective cohort study
Radiation green synthesis of Guar gum -Pectin/ Polyacrylamide/ zinc oxide superabsorbent hydrogel composites for sustainable agriculture
Authors: Sayed Asmaa , Mohamed Mai M. , Abdel-Raouf Manar , Adel Ghada 
Published: August 2022

Abstract
In the current study, the performance of superabsorbent hydrogel composites comprised of Guar gum-Pectin/ Polyacrylamide/ ZnO crosslinked with gamma irradiation (10 kGy) has been investigated for sustainable agriculture. The claimed composites (GG/PC/PAAm/ZnOx) were characterized by FTIR, TGA, and AFM. The swelling capacity data reveal that the equilibrium water swelling (EW) of the composites was increased by increasing the ZnO content from 600 g/g to 1050 g/g for zero to the highest concentration of ZnO, respectively. Furthermore, the physical properties of the soil mixed with the hydrogels were improved; water holding capacity (WHC) increased to 66% and water retention (WR) kept at 15% after 20 days. The composites showed a good degradability in the biodegradation test. They also portrayed super-absorption capacity at three swelling/deswelling cycles. This advancement is important for reducing water consumption through the irrigation of arid lands. The prepared composites were proved as excellent candidates in sustainable agriculture applications.
Highly accurate species identification of eastern Pacific rockfishes (Sebastes spp.) with high-throughput DNA sequencing
Authors: Baetscher Diana S. , Nuetzel Hayley , Garza John Carlos 
Published: August 2022

Abstract
Genetic species identification is often necessary for species flocks, such as rockfishes in the genus Sebastes (Teleostei, Scorpaenidae), where traditional visual identification methods are challenged by the presence of many sympatric species with morphologically similar juveniles. Here we present a straightforward approach for performing species identification in rockfishes using 96 nuclear microhaplotype loci that can be efficiently genotyped using high-throughput DNA sequencing. Self-assignment of nearly 1 000 samples from 54 species resulted in > 99% accurate species identification at a 95% confidence threshold. Phylogenetic relationships of Sebastes uncovered with these same loci were highly concordant with relationships previously derived primarily with mitochondrial DNA. We also assessed ascertainment bias and consequent reduced nucleotide diversity and heterozygosity in non-ascertainment species to understand the potential utility of these markers for those species. The data and protocol presented here will be useful for research and management of rockfishes in the northeastern Pacific Ocean.
Metastatic Colorectal Cancer as the Primary Phenotype in a Hereditary Breast and Ovarian Cancer Patient with Germline BRCA1 Mutation: A Case Report
Authors: Liu Ying , Zhu Jing , Wei Xiao , Yang Duoxia , Li Si , Qian Xiaoping , Li Li 
Published: August 2022

Abstract
Hereditary breast and ovarian cancer (HBOC) syndrome has increased predisposition to breast and/or ovarian cancer, and 24% of families with HBOC were associated with the germline pathogenic variants in BRCA1/2. Timely diagnosis and identification of mutation carriers is of utmost importance to improve survival benefit and quality of life. Cancers that has been included into screening of BRCA1/2 associated HBOC included prostate and pancreatic cancers etc.. In this case, we reported a patient who first presented symptom of CRC and was finally diagnosed as BRCA1 associated HBOC with advanced peritoneal carcinoma. With strategies of cetuximab based treatment and olaparib, and debulking surgeries, she has achieved an overall survival (OS) > 35 months. The aim was to indicate that HBOC might also first present as CRC, and comprehensive next-generation sequencing analysis might be a key complement for screening and diagnose of HBOC.
Evaluation of serum Fe concentration as an alternative biomarker for inflammation in cattle
Authors: MURAKAMI Yoshiki , TSUKANO Kenji , HIRATA Haruyuki , SUZUKI Kazuyuki 
Published: August 2022

Abstract
This study aimed to clarify the relationship between acute phase protein (APP) concentrations and serum Fe concentrations to determine whether serum iron (Fe) can be clinically applied as a substitute for APPs in cattle. One hundred and five Holstein-Friesian breed dairy cows were enrolled in this study. The cows were divided into forty-three healthy cows and sixty-two cows with inflammatory diseases. The plasma haptoglobin (HPT), alpha-1 acid glycoprotein (AGP), serum amyloid A (SAA), serum Fe levels, and other biochemical parameters in the cows were measured. From the results, HPT and AGP were significantly higher in inflammatory disease cattle compared with the control group, but no odds ratios were determined in the binomial analysis. Significant differences in SAA and serum Fe concentrations were observed between the inflammatory disease and control groups and odds ratios were determined in the binomial analysis. In addition, the cutoff value of Fe could be used to diagnose the inflammatory disease to the same degree as the cutoff value of SAA. The results suggested that serum Fe can be used as a substitute for APPs in the production of animal medicine.
Insights into a novel pathway of paraben-induced endotoxin affecting human sperm quality: Parabens’ dual effects of antibacterial and estrogenic activity
Authors: Zhang Linyuan , Song Pengkun , Guo Ying , Ding Chunguang , Xu Jianfeng , Yuan Dong , Qiao Peihuan , Huo Junsheng , Huang Jian , Chang Bing , Liang Xiaowei , Ding Gangqiang 
Published: August 2022

Abstract
Background
The decline of human sperm quality has caused great concern. Whether exposure to parabens and the intestinal endotoxin (IE) they induce are related to sperm quality is a challenging scientific question.
Results
We measured seminal methyl-(MeP), ethyl-(EtP), propyl-(PrP), and butyl-(BuP) parabens, their metabolites PHBA and 3,4-DHB, semen parameters, and blood IE (lipopolysaccharide, LPS) of 315 healthy men. Bivariate correlation and multiple linear regression were used to evaluate their interrelationships. For the first time, we found that MeP, EtP, PrP, BuP, PHBA, and 3,4-DHB in semen were negatively correlated with sperm parameters (r = − 0.184 to − 0.438), with EtP showing the strongest correlation. LPS was detected in all plasma samples (0.021–0.195 EU/mL) and negatively correlated with sperm concentration and total sperm count with R2 = 0.295 and R2 = 0.236, respectively, when LPS was higher than 0.104 EU/mL. LPS was positively correlated with EtP and BuP.
Conclusion
We concluded that seminal parabens affected sperm quality possibly due to estrogenic activity. Parabens likely promote intestinal endotoxemia and affect sperm quality in healthy people by altering the composition of gut microbiota through antimicrobial activity. The finding that parabens exert dual toxicological effects on sperm quality provides novel insights for future research.
TP53 mutation–associated and copy number–dependent KDM7A-DT expression affects DNA repair and promotes invasive breast cancer progression
Authors: Giannakakis Antonis , Tsifintaris Margaritis , Gouzouasis Vasilis , Tafyllou Charisiostrian , Ow Ghim Siong , Papp Csaba , Ivshina Anna , kuznetsov vladimir 
Published: August 2022

Abstract
Background: Recent characterisation of stress-induced promoter-associated antisense lncRNAs (si-paancRNAs) suggests that these lncRNAs modulate transcription, cellular responses to oxidative, metabolic and genotoxic stress, and may be part of the pathways critical in cancer. KDM7A divergent transcribed (KDM7A-DT) is among the top overexpressed genes encoded by such lncRNAs. The mechanisms leading to aberrant KDM7A-DT transcription, transcript biogenesis, and downstream functions of KDM7A-DT isoforms in breast cancer (BC) types and subtypes have not been studied. Methods: Cell line models, biochemistry methods and microarrays experiments for overexpression and knockdown of KDM7A-DT were used. Next, integration of experimental models, bioinformatics, and massive BRCA patient metadata analyses were performed to investigate the mechanisms and functions of KDM7A-DT.Results: The stable KDM7A-DT overexpression in non-malignant cells upregulates p53, CDKN1A, and γH2AX signalling, resulting in a prolonged cell growth retardation phenotype and preferential depletion of epithelial-to-mesenchymal transition (EMT) pathway–associated tumour suppressor genes. Importantly, KDM7A-DT induction by acute oxidative stress of semi-transformed fibroblasts is p53-dependent. According to BC clinical metadata, KDM7A-DT is overexpressed in poor survival basal-like BC (BLBC) subtype. The KDM7A-DT overexpression is associated with the overexpression of the TP53-missense mutated gene and KDM7A-DT full-length copy number amplification. KDM7A-DT overexpression affects DNA repair via the non-homologous end-joining (NHEJ) pathway, inhibits tumor suppressors involved in EMT, induces pro-oncogenic metabolic changes, and correlates with histologic grades, aneuploidy, hypoxia, cancer-associated proteins, clinical and molecular markers.Conclusion: KDM7A-DT is the TP53 mutation–associated and copy number–dependent pro-oncogene si-paancRNAs that contributes to genome instability, initiation, progression, invasiveness, and BLBC outcomes.
Thermal conductivity of binary Platinum-Iridium alloys
Authors: Sun Hongsheng , Chen Haoran , Chen Yu , Wei Chaoqun , Wang Qing , Gan Youyu , Qi Yanwu , Wang Jianli 
Published: August 2022

Abstract
Measurements of thermal conductivity and electrical conductivity of Platinum-Iridium alloys at different compositions are performed. The thermal conductivities measured by the electrical-heating method and the cross-wire geometry agree well with each other. For the binary alloys with Ir compositions of 6 at.% to 15 at.%, the thermal conductivity varies linearly with temperature, which can be related to the electrical counterpart by using the classical Simth-Palmer formula. The lattice component of the thermal conductivity is found to be nearly composition-independent, contributing to about 20~25% of the total thermal conductivity.
Identification of 7 key genes as biomarkers for prognosis and metastasis of gastric cancer
Authors: Fan Shuyuan , Qiu Feng , Liu jing , Li bin , Li Kun , Diao yunpeng 
Published: August 2022

Abstract
Background
Gastric cancer is one of the most common tumors in the GI system worldwide. The refractory nature of gastric cancer and the increasing risk of recurrence and metastasis with inadequate treatment have led to numerous reports of death due to recurrence and metastasis of gastric cancer. In turn, potential mechanisms and potential biomarkers for the prevention of cancer metastasis have become a major task in clinical cancer research.
Methods
Differential genes (DEGs) up- and down-regulated in the GEO dataset (GSE118897) were identified, and 145 gastric cancer patients from the TCGA database were evaluated for differential gene prognosis and the impact of high expression of these genes in gastric cancer tissues on survival of gastric cancer patients was explored.
Results
A total of 90 DEGs were identified, of which 33 were expressed up-regulated and 57 were expressed down-regulated. By screening genes that were highly expressed in tumor tissues and had poor prognosis for gastric cancer patients, seven key genes were finally screened, including CEACAM7, THBS2, TREM2, MFAP2, BGN, MMP1 and NUSAP1. The expression levels of these genes were shown to correlate with overall survival by survival analysis. These genes are involved in biological processes such as cell proliferation and division, while being reflected in the KEGG-enriched pathway with a higher cell cycle and inflammatory response. Further analysis revealed that all seven genes can affect the proliferation and metastasis of cancer cells, with significant correlation with increasing expression, suggesting a possible significant implication for the prevention and targeted treatment of gastric cancer.
Two-fluid numerical model of chromospheric1heating and plasma outflows in a quiet-Sun
Authors: Murawski Kris , Musielak Zdzislaw , Poedts Stefaan , Srivast Abhishek 
Published: August 2022

Abstract
Purpose: This paper addresses long-standing solar physics problems, namely, the heating of the solar chromosphere and the origin of the solar wind. Our aim is to reveal the related mechanisms behind chromospheric heating and plasma outflows in a quiet-Sun. Methods: The approach is based on a two-fluid numerical model that accounts for thermal non-equilibrium (ionization/recombination), non-adiabatic and non-ideal dynamics of protons+electrons and hydrogen atoms. The model is applied to numerically simulate the propagation and dissipation of granulation-generated waves in the chromosphere and plasma flows inside a quiet region. Results: The obtained results demonstrate that collisions between protons+electrons and hydrogen atoms supplemented by plasma viscosity, magnetic resistivity, and recombination lead to thermal energy release, which compensates radiative and thermal losses in the chromosphere, and sustains the atmosphere with vertical profiles of averaged temperature and periods of generated waves that are consistent with recent observational data. Conclusion: Our model conjectures a most robust and global physical picture of granulation generated wave motions, plasma flows, and subsequent heating, which form and dynamically couple the various layers of the solar atmosphere.
Precise solutions to the Bogoyavlenskii equation byextended rational techniques
Authors: Karchi Nikan Ahmadi , Ghaemi Mohammad Bagher , Vahidi Javad 
Published: August 2022

Abstract
In this article, after implementing traveling wave solutions on the Bogoyavlenskii equation ,and then by employing the extended rational methods, we reachsolutions. One of the applicability ways to find the solutions of nonlinear evolution equations are proposed in this paper.
Effect of timing of bronchodilator therapy initiation on exacerbations in patients with chronic obstructive pulmonary disease: a retrospective cohort study
Authors: Yamada Hideyasu , Matsumoto Isao , Makita Naoyuki , Arita Yoshifumi , Hayashi Nobuya , Mitsuoka Kurena , Tashiro Naoki , Hizawa Nobuyuki 
Published: August 2022

Abstract
Background: The benefit of prompt vs delayed treatment initiation with inhaled long-acting bronchodilators in reducing exacerbations in chronic obstructive pulmonary disease (COPD) is unclear. This study aimed to investigate if long-acting bronchodilator therapy initiation within 30 days of COPD diagnosis reduces exacerbation risk in patients with COPD. Methods: This was a retrospective cohort study of patients with COPD based on claims and electronic medical records data extracted from the Real World Data database. The index date (day 0) was the date of the first confirmed inpatient or outpatient COPD diagnosis between January 1, 2005, and December 31, 2018. Patients with COPD without an asthma diagnosis and aged ≥40 years at the index date were included. Patients who initiated inhaled long-acting bronchodilator therapy within the first 30 days (day 0 to day 29) were categorized into the “prompt therapy” group and the rest into the “delayed therapy” group. Time from day 30 post-diagnosis to the first exacerbation and annual exacerbation rate (AER) were evaluated for the overall population and those stratified by COPD phenotype, including chronic bronchitis (CB) and emphysema. Results: Compared with the delayed therapy group (n=1,516), time to first exacerbation was prolonged (hazard ratio 0.78; 95% confidence interval [CI] [0.70, 0.87]) and annual rates of moderate or severe exacerbations were lower (rate ratio 0.74; 95% CI [0.65, 0.84]) in the prompt therapy group (n=1,466). Similarly, time to first exacerbation was prolonged and AERs were lower in the prompt therapy group in the subgroups of patients with CB or emphysema. Conclusions: This is the first study to demonstrate a prolonged time to first exacerbation upon initiation of long-acting bronchodilators within 30 days of COPD diagnosis. A beneficial effect was also observed in patients with CB and emphysema. Our data support advising patients to initiate long‑acting bronchodilators soon after COPD diagnosis.
Maximum, Minimum and Daily Temperature Range Trends as an Indication of Global Climate Change; Beer Sheva Israel
Authors: Kudish Avraham I , Evseev Efim G 
Published: August 2022

Abstract
An in-depth trend analysis of a database consisting of dry bulb temperatures measured at Beer Sheva, Israel during the time interval between August 1988 and December 2021 is presented. Beer Sheva is located at the northern edge of the semi-arid Negev region of Israel. Trend analyses were applied first to the mean diurnal (06:00-18:00), nocturnal (18:00-06:00) and daily (24 hour) time intervals. Positive trends were detected for all months of the year for both diurnal and nocturnal time intervals with the exception of April and December. The positive trends were in the range of 1.13 and 0.33°C/decade. The magnitude of the positive trends for the nocturnal time interval were greater than that of the diurnal for six months of the year and essentially equal during the month of November. In the case of the daily time interval positive trends were found throughout the year with the exception of April. The positive trends were in the range of 1.05 and 0.41°C/decade. The second phase of the study was a trend analyses performed on the daily maximum, daily minimum and Daily Temperature Range (DTR). The daily maximum temperature exhibited positive trends only during January, February, March, July and August, whereas the daily minimum temperature trends were positive throughout the year. In addition, only during January and February were the maximum daily temperatures greater that the corresponding minimum temperatures; during March there were essentially the same. The DTR was found to possess negative trends from May through October. The highest negative trend, -0.96°C/decade, is in June and the lowest negative trend, -0.48°C/decade, occurs in October.