bluuebunny/crossref_metadata_2025_split huggingface dataset:
Response of internal carotid artery blood flow velocity to fluid challenge under general anesthesia in pediatric patients with moyamoya disease: A prospective observational study
Authors: Kim Eun‐Hee , Park Jung‐Bin , Kang Pyoyoon , Ji Sang‐Hwan , Jang Young‐Eun , Lee Ji‐Hyun , Kim Jin‐Tae , Kim Hee‐Soo 
Published: September 2022

AbstractBackgroundMaintaining cerebral blood flow is important in intraoperative management of moyamoya disease patients.AimsTo access changes in the carotid artery blood flow velocity in response to fluid challenge, blood pressure, and cardiac output under general anesthesia in pediatric patients with moyamoya disease.MethodsThis observational study included pediatric patients with moyamoya disease undergoing general anesthesia for encephaloduroarteriosynangiosis. Each patient underwent an ultrasound assessment thrice as follows: after anesthetic induction (T1), after fluid challenge (10 ml/kg, T2), and at the end of surgery (T3). The primary outcome was the change in the internal carotid artery blood flow velocity after fluid challenge and was assessed using a paired t‐test. The secondary outcomes comprised changes in the internal, external, and common carotid artery blood flow peak velocities after fluid challenge and the factors influencing these changes.ResultsWe enrolled and analyzed 30 patients with a mean age of 7.2 years. After fluid challenge, the systolic (p = .003) and mean blood pressure (p = .017), stroke volume index (p = .008), and cardiac index (p = .140) were higher than those at T1. However, both internal carotid artery blood flow velocities did not change after fluid challenge (p = .798, mean difference and 95% confidence interval [CI], −1.1 and −10.3 to 8.0 for right, p = .164, mean difference and 95% CI, −5.2 and −12.7 to 2.2 for left). The internal carotid artery blood flow velocity was correlated with the cardiac index, stroke volume index, and mean and diastolic blood pressure, with low significance.ConclusionsThe internal carotid artery blood flow velocity did not increase in pediatric patients with moyamoya disease under general anesthesia, despite fluid challenge and corresponding changes in the blood pressure and cardiac output. Intraoperative hemodynamic management to improve the cerebral blood flow in these patients requires further investigation.
Role of glycerophosphodiester phosphodiesterase in rice leaf blades in elevated CO2 environments
Authors: Kim Y. , Takahashi S. , Obayashi H. , Miyao M. 
Published: September 2022

ABSTRACT

Glycerophosphodiester phosphodiesterase (GDPD; EC 3.1.4.46) is involved in plant phosphate (Pi) utilization and its expression is upregulated under phosphorus (P)‐deficient conditions. Although rice was grown under P‐sufficient conditions, the transcript levels of specific OsGDPD were upregulated in mature rice leaf blades (LB) in elevated CO2 (eCO2) environments.

Expression and subcellular localization of GDPD, and contents of Pi, sugar phosphates and carbohydrates were analysed to clarify the physiological function of GDPD in rice under eCO2.

Under eCO2, expression of specific OsGDPD increased only in mature rice LB in which low Pi concentrations were observed. Moreover, eCO2‐induced OsGDPD2 and OsGDPD3 were localized in the plastid, indicating that GDPD2 and GDPD3 may be related to plastidic functions, such as carbon assimilation. Although rice LB contained more carbohydrates under eCO2 than under ambient CO2, the phosphoglucose content decreased under eCO2, suggesting that the need for excess phosphoglucose to synthesize carbohydrates under eCO2 causes a local Pi deficiency. Furthermore, we confirmed that glycerol‐3‐phosphate produced by the catalysis of GDPD from glycerophosphodiester contributes to carbohydrate accumulation in rice LB.

Our findings suggest that local Pi deficiency due to excess carbohydrate accumulation under eCO2 influences GDPD to enhance glycerophosphodiester hydrolysis.
Evaluation of aural masses submitted as inflammatory polyps in 20 dogs (2000–2020)
Authors: Schuldenfrei Marvin D. , Lam Andrea T. H. , Outerbridge Catherine A. , White Stephen D. , Affolter Verena K. 
Published: September 2022

AbstractBackgroundCanine non‐neoplastic aural polypoid masses (APMs) are uncommon, with few published studies.ObjectivesThe aim of this retrospective study was to characterise the clinical presentation, diagnostic imaging and histopathological results for APMs submitted as aural inflammatory polyps (AIPs).AnimalsTwenty dogs with APMs evaluated at a veterinary teaching hospital.Materials and MethodsCases were selected by searching computerised medical records from 2000 to 2020, using keywords ‘canine’, ‘aural/otic polyp’ and ‘aural/otic inflammatory mass’. Histological samples and medical records were reviewed.ResultsIn 14 of 20 dogs, external ear canal masses were characterised by keratinised squamous epithelium with or without adnexa. Tympanic bulla origin was confirmed in four of 20 dogs by the presence of cuboidal to ciliated columnar epithelium, with or without squamous epithelium. The site of origin could not be determined in two dogs. Diagnostic imaging (MRI or CT) confirmed APM presence in 14 of 20 dogs. Otitis media was diagnosed in four of four tympanic bulla APMs and seven of 13 ear canal APMs. In 18 of 20 dogs, debulking, traction avulsion, and total ear canal ablation and bulla osteotomy led to APM resolution in two of eight, four of six and four of four dogs, respectively.Conclusions and Clinical RelevanceType of epithelium was a key feature in determining the APM origin, and interpretation in conjunction with video otoscopy and diagnostic imaging was crucial. Canine APMs more commonly arose from the ear canal. Tympanic bulla APMs and APMs of undetermined origin were comparable to feline AIPs. Regardless of APM origin site, debulking had the greatest likelihood of recurrence.
Simple and Effective Fault Diagnosis Method of Power Lithium-Ion Battery Based on GWA-DBN
Authors: Bin Pan , Wen Gao , Yuhang Peng , Zhili Hu , Lujun Wang , Jiuchun Jiang 
Published: September 2022

Abstract
In order to improve the accuracy of battery pack inconsistency fault detection, an optimal deep belief network (DBN) single battery inconsistency fault detection model based on the gray wolf algorithm (GWA) was proposed. The performance of the DBN model is affected by the weights and bias parameters, and the gray wolf algorithm has a good ability to seek optimization, so the gray wolf algorithm is used to optimize the connection weights of the DBN model. Therefore, the accuracy rate of battery inconsistency diagnosis is improved. The battery voltage characteristic data is used as the input signal of the DBN model. The health and faults of the single cells are used as the output signals of the DBN model. The battery inconsistency fault detection model of GWA-DBN is established. Through the comparison and simulation with other algorithms, it is proved that the designed model has higher diagnostic accuracy, better fitting effect, and good application prospect.
Wave Propagation in Timoshenko–Ehrenfest Nanobeam: A Mixture Unified Gradient Theory
Authors: Faghidian S. Ali , Elishakoff Isaac 
Published: September 2022

Abstract
A size-dependent elasticity theory, founded on variationally consistent formulations, is developed to analyze the wave propagation in nanosized beams. The mixture unified gradient theory of elasticity, integrating the stress gradient theory, the strain gradient model, and the traditional elasticity theory, is invoked to realize the size effects at the ultra-small scale. Compatible with the kinematics of the Timoshenko–Ehrenfest beam, a stationary variational framework is established. The boundary-value problem of dynamic equilibrium along with the constitutive model is appropriately integrated into a single function. Various generalized elasticity theories of gradient type are restored as particular cases of the developed mixture unified gradient theory. The flexural wave propagation is formulated within the context of the introduced size-dependent elasticity theory and the propagation characteristics of flexural waves are analytically addressed. The phase velocity of propagating waves in carbon nanotubes (CNTs) is inversely reconstructed and compared with the numerical simulation results. A viable approach to inversely determine the characteristic length-scale parameters associated with the generalized continuum theory is proposed. A comprehensive numerical study is performed to demonstrate the wave dispersion features in a Timoshenko–Ehrenfest nanobeam. Based on the presented wave propagation response and ensuing numerical illustrations, the original benchmark for numerical analysis is detected.
Development of GPC2-directed chimeric antigen receptors using mRNA for pediatric brain tumors
Authors: Foster Jessica B , Griffin Crystal , Rokita Jo Lynne , Stern Allison , Brimley Cameron , Rathi Komal , Lane Maria V , Buongervino Samantha N , Smith Tiffany , Madsen Peter J , Martinez Daniel , Delaidelli Alberto , Sorensen Poul H , Wechsler-Reya Robert J , Karikó Katalin , Storm Phillip B , Barrett David M , Resnick Adam C , Maris John M , Bosse Kristopher R 
Published: September 2022

BackgroundPediatric brain tumors are the leading cause of cancer death in children with an urgent need for innovative therapies. Glypican 2 (GPC2) is a cell surface oncoprotein expressed in neuroblastoma for which targeted immunotherapies have been developed. This work aimed to characterize GPC2 expression in pediatric brain tumors and develop an mRNA CAR T cell approach against this target.MethodsWe investigated GPC2 expression across a cohort of primary pediatric brain tumor samples and cell lines using RNA sequencing, immunohistochemistry, and flow cytometry. To target GPC2 in the brain with adoptive cellular therapies and mitigate potential inflammatory neurotoxicity, we used optimized mRNA to create transient chimeric antigen receptor (CAR) T cells. We developed four mRNA CAR T cell constructs using the highly GPC2-specific fully human D3 single chain variable fragment for preclinical testing.ResultsWe identified high GPC2 expression across multiple pediatric brain tumor types including medulloblastomas, embryonal tumors with multilayered rosettes, other central nervous system embryonal tumors, as well as definable subsets of highly malignant gliomas. We next validated and prioritized CAR configurations using in vitro cytotoxicity assays with GPC2-expressing neuroblastoma cells, where the light-to-heavy single chain variable fragment configurations proved to be superior. We expanded the testing of the two most potent GPC2-directed CAR constructs to GPC2-expressing medulloblastoma and high-grade glioma cell lines, showing significant GPC2-specific cell death in multiple models. Finally, biweekly locoregional delivery of 2–4 million GPC2-directed mRNA CAR T cells induced significant tumor regression in an orthotopic medulloblastoma model and significantly prolonged survival in an aggressive orthotopic thalamic diffuse midline glioma xenograft model. No GPC2-directed CAR T cell related neurologic or systemic toxicity was observed.ConclusionTaken together, these data show that GPC2 is a highly differentially expressed cell surface protein on multiple malignant pediatric brain tumors that can be targeted safely with local delivery of mRNA CAR T cells, laying the framework for the clinical translation of GPC2-directed immunotherapies for pediatric brain tumors.
Investigating two-zero textures of inverse neutrino mass matrix under the lamp post of LMA and LMA-D solutions and symmetry realization
Authors: Singh Labh , Kashav Monal , Verma Surender 
Published: September 2022

AbstractIn this work we have investigated the phenomenological consequences of two-zero textures of inverse neutrino mass matrix ($$M_{\nu }^{-1}$$

M

ν

-
1

) in light of the large mixing angle (LMA) and large mixing angle-dark (LMA-D) solutions, later of which originates if neutrinos exhibit non-standard interactions with matter. Out of fifteen possibilities, only seven two-zero textures of $$M_{\nu }^{-1}$$

M

ν

-
1

are found to be phenomenologically allowed under LMA and/or LMA-D descriptions. In particular, five textures are in consonance with both LMA and LMA-D solutions and are necessarily CP violating while remaining two textures are found to be consistent with LMA solution only. The textures with vanishing (1, 1) element of $$M_{\nu }^{-1}$$

M

ν

-
1

are, in general, disallowed. All the textures allowed under LMA and LMA-D solutions follow the same neutrino mass hierarchy. Furthermore, textures with vanishing (2, 3) element of $$M_{\nu }^{-1}$$

M

ν

-
1

are found to be either disallowed or are consistent with LMA description only. We have, also, obtained the implication of the model for $$0\nu \beta \beta $$

0
ν
β
β

decay amplitude $$|M_{ee}|$$

|

M

ee

|

. For most of the textures the calculated $$3\sigma $$

3
σ

lower bound on $$|M_{ee}|$$

|

M

ee

|

is $$\mathcal {O}(10^{-2})$$

O
(

10

-
2

)

, which is within the sensitivity reach of $$0\nu \beta \beta $$

0
ν
β
β

decay experiments. We have, also, proposed a flavor model based on discrete non-Abelian flavor group $$A_4$$

A
4

wherein such textures of $$M_{\nu }^{-1}$$

M

ν

-
1

can be realized within Type-I seesaw setting.
Analysis of Muscular Electrical Activity and Blood Perfusion of Upper Extremity in Patients with Hemiplegic Shoulder Pain: A Pilot Study
Authors: Sui Minghong , Jiang Naifu , Yan Luhui , Zhang Chenxi , Liu Jiaqing , Yan Tiebin , Li Guanglin 
Published: September 2022

Background. Hemiplegic shoulder pain (HSP) is a common symptom for post-stroke patients, which has a severely adverse impact on their rehabilitation outcomes. However, the cause of HSP has not been clearly identified due to its complicated multifactorial etiologies. As possible causes of HSP, the abnormality of both muscular electrical activity and blood perfusion remains lack of investigations. Objective. This study aimed to analyze the alteration of muscular electrical activity and blood perfusion of upper extremity in patients with HSP by using surface electromyography (sEMG) and laser speckle contrast imaging (LSCI) measurement techniques, which may provide some insight into the etiology of HSP. Methods. In this observational and cross-sectional study, three groups of participants were recruited. They were hemiplegic patients with shoulder pain (HSP group), hemiplegic patients without shoulder pain (HNSP group), and healthy participants (Healthy group). The sEMG data and blood perfusion data were collected from all the subjects and used to compute three different physiological measures, the root-mean-square (RMS) and median-frequency (MDF) parameters of sEMG recordings, and the perfusion unit (PU) parameter of blood perfusion imaging. Results. The RMS parameter of sEMG showed significant difference (

p
<
0.05

) in the affected side between HSP, HNSP, and Healthy groups. The MDF parameter of sEMG and PU parameter of blood perfusion showed no significant difference in both sides among the three groups (

p
>
0.05

). The RMS parameter of sEMG showed a statistically significant correlation with the pain intensity (

r

= -0.691,

p

=0.012). Conclusion. This study indicated that the muscular electrical activity of upper extremity had a correlation with the presence of HSP, and the blood perfusion seemed to be no such correlation. The findings of the study suggested an alternative way to explore the mechanism and treatment of HSP.
A Novel B7-H6–Targeted IgG-Like T Cell–Engaging Antibody for the Treatment of Gastrointestinal Tumors
Authors: Zhang Wei , Auguste Aurélie , Liao Xiaoyun , Walterskirchen Christian , Bauer Kathrin , Lin Yu-Hsi , Yang Ling , Sayedian Farzaneh , Fabits Markus , Bergmann Michael , Binder Carina , Corrales Leticia , Vogt Anne B. , Hudson Lindsey J. , Barnes Martin P. , Bisht Arnima , Giragossian Craig , Voynov Vladimir , Adam Paul J. , Hipp Susanne 
Published: September 2022

Abstract

Purpose:
Advanced-stage gastrointestinal cancers represent a high unmet need requiring new effective therapies. We investigated the antitumor activity of a novel T cell–engaging antibody (B7-H6/CD3 ITE) targeting B7-H6, a tumor-associated antigen that is expressed in gastrointestinal tumors.

Experimental Design:
Membrane proteomics and IHC analysis identified B7-H6 as a tumor-associated antigen in gastrointestinal tumor tissues with no to very little expression in normal tissues. The antitumor activity and mode of action of B7-H6/CD3 ITE was evaluated in in vitro coculture assays, in humanized mouse tumor models, and in colorectal cancer precision cut tumor slice cultures.

Results:
B7-H6 expression was detected in 98% of colorectal cancer, 77% of gastric cancer, and 63% of pancreatic cancer tissue samples. B7-H6/CD3 ITE-mediated redirection of T cells toward B7-H6–positive tumor cells resulted in B7-H6–dependent lysis of tumor cells, activation and proliferation of T cells, and cytokine secretion in in vitro coculture assays, and infiltration of T cells into tumor tissues associated with tumor regression in in vivo colorectal cancer models. In primary patient-derived colorectal cancer precision-cut tumor slice cultures, treatment with B7-H6/CD3 ITE elicited cytokine secretion by endogenous tumor-infiltrating immune cells. Combination with anti-PD-1 further enhanced the activity of the B7-H6/CD3 ITE.

Conclusion:
These data highlight the potential of the B7-H6/CD3 ITE to induce T cell–redirected lysis of tumor cells and recruitment of T cells into noninflamed tumor tissues, leading to antitumor activity in in vitro, in vivo, and human tumor slice cultures, which supports further evaluation in a clinical study.
GSTA4 Governs Melanoma Immune Resistance and Metastasis
Authors: Ucche Sisca , Yokoyama Satoru , Mojic Marija , Oki Kohei , Ohshima Chikako , Tsuihiji Haruka , Takasaki Ichiro , Tahara Hideaki , Hayakawa Yoshihiro 
Published: September 2022

Abstract
Among factors involved in cancer cells escaping from immune responses, an intrinsic defect in the IFNγ response is considered to be one of the major players allowing cancer cells to evade the host immunity. In this study, we investigated how tumor cells escape from the IFNγ-dependent immune response through the immunoediting process by analyzing originally established immune-escape variants of melanoma cells. We found that the immune-escape melanoma variants gained resistance to the IFNγ-induced oxidative stress response and identified glutathione-S-transferase-4 (GSTA4) as a critical molecule in this process. Furthermore, the immune escape melanoma variants acquired a greater metastatic ability by a GSTA4-dependent mechanism.

Implications:
Considering the importance of GSTA4 in controlling IFNγ responsiveness and the metastatic potential of other melanoma cells, our results highlight a novel mechanism whereby cancer cells escape from host immunity and gain metastatic ability by acquiring resistance to oxidative stress responses through the upregulation of GSTA4.
Not the End of the Story
Authors: van Schaik Anne-Rieke 
Published: September 2022

Abstract
Central to this article are two maps by Floris Balthasarsz van Berckenrode, both on the siege of Grave (1602) by Maurice of Orange during the Dutch Revolt. The first map was in 1602 produced as a news map about the events, the second was a re-edition, published eight years later as a book illustration for Jan Jansz Orlers, Den Nassauschen Lauren-Crans (Leiden 1610). In this article, principles for a new method are introduced to analyse and compare these ‘story maps’ with particular attention to the narrative impact of the map. Using this method in combi-nation with (book) historical research, it argues that the 1610 map should be considered as a ‘memorial map’ that reframes the collective memory of the Dutch Revolt. It emphasizes the dynamic relationship between news, map and book publishing and pleads for a more prominent position of story maps and book illustrations in Early Modern memory landscapes.
Of Poets, Prophets, and Printers
Authors: Penman Leigh T.I. 
Published: September 2022

Abstract
This article identifies the personalities and circumstances behind two previously unknown heterodox religious publishing projects of the seventeenth century. The first was based in Leiden in the United Provinces, while the second originated in Dresden in Electoral Saxony. The Leiden project was likely led by the German jurist Johann Angelius Werdenhagen, who in 1628 had Jacob Böhme’s Weg zu Christo and Anna Ovena Hoyer’s Gespräch Eines Kindes mit seiner Mutter printed in Leiden at the presses of Govert Basson. This project demonstrates Werdenhagen’s centrality in the early distribution of Böhme’s theosophical doctrines in the United Provinces. The Dresden project was funded by Rosine Vogtin, who from 1642 commissioned the office of Gimel Bergen to print works by Jacob Böhme and Ludwig Friedrich Gifftheil.
Learnings From Longitudinal Patient‐Reported and Clinical Outcomes in Palliative Head and Neck Cancer Care
Authors: Dorr Maarten C. , Sewnaik Aniel , Berzenji Diako , van Hof Kira S. , Grevelink Tim , Baatenburg de Jong Robert J. , Offerman Marinella P. J. 
Published: September 2022

AbstractObjectivePatients with palliative head and neck cancer experience many symptoms in a short period of time. Longitudinal data on patient‐reported outcomes in this phase are lacking. The aim of this study is to use structurally obtained patient‐reported outcome data combined with clinical patient data and obtain insight in patient‐reported outcomes, survival, circumstances of death, and interventions and treatment during the palliative phase in order to improve the quality of end‐of‐life care and patient‐centered counseling.Study DesignLongitudinal observational cohort study.SettingTertiary cancer center.MethodQuality of life was prospectively collected using the European Organization for Research and Treatment of Cancer QLQ‐C15‐PAL. Tumor‐ and patient‐specific data were retrospectively collected. Descriptive statistics, linear mixed models, and regression analyses were performed.ResultsA significant deterioration was found in global health status, physical functioning, fatigue, dyspnea, appetite loss, and constipation over time. However, emotional functioning improved. Median survival was 5.1 months, and only a low percentage of in‐hospital death was observed (7.8%). Higher global health status at intake was associated with prolonged survival.ConclusionStructural measurement of patient‐reported outcome together with clinical outcomes provides unique insight, which enables improvement of patient‐centered counseling and care.
Case Report of Wernicke’s Encephalopathy After Sleeve Gastrectomy
Authors: Hamilton Leslie A. , Darby Sarah H. , Hamilton Allan J. , Wilkerson Matthew H. , Morgan Kabel A. 
Published: September 2022

AbstractBackground: We report a case of a patient who was 3 months post–sleeve gastrectomy and presented with acute stroke symptoms ultimately due to Wernicke’s encephalopathy (WE) after bariatric surgery. A 20‐year‐old white female presented to an outside hospital 3 months after sleeve gastrectomy complaining of nausea and vomiting. She initially underwent a cholecystectomy and later became less responsive and required intubation. Magnetic resonance imaging changes, presumed to be an acute stroke, prompted her transfer to our facility. Intravenous (IV) thiamin was administered, and the patient’s symptoms improved over the course of her hospital stay. Results: Thiamin levels were markedly low, and the patient rapidly improved with the administration of IV thiamin. The patient was discharged to inpatient rehabilitation. Conclusion: Bariatric surgery is a less common cause of WE but can lead to acute WE due to malabsorption of thiamin. In patients undergoing bariatric surgery, clinicians should be vigilant about the potential for WE to occur. In addition, based on history, WE should be considered in the differential diagnosis for symptoms of acute ischemic stroke.