bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison of the CIPHER prognostic model with the existing scores in predicting severe maternal outcomes during intensive care unit admission
Authors: Silva Flávio X. , Parpinelli Mary A. , Oliveira‐Neto Antonio F. , Ribeiro do Valle Carolina C. , Souza Renato T. , Costa Maria L. , Correia Mario D. T. , Katz Leila , Cecatti José G. 
Published: February 2022

AbstractObjectiveTo compare the performance of the Collaborative Integrated Pregnancy High‐Dependency Estimate of Risk (CIPHER) model in predicting maternal death and near‐miss morbidity (Severe Maternal Outcome [SMO]) with the Sequential Organ Failure Assessment (SOFA), the Acute Physiology and Chronic Health Evaluation (APACHE) II, and the Simplified Acute Physiology Score (SAPS) III scores.MethodsA retrospective and a prospective study was conducted at two centers in Brazil. For each score, area under curve (AUC) was used and score calibration was assessed using the Hosmer‐Lemeshow statistic (H‐L) test and the standardized mortality ratio (SMR).ResultsA cohort of 590 women was analyzed. A SMO was observed in 216 (36.6%) women. Of these, 13 (2.2%) were maternal deaths and 203 (34.4%) met one or more maternal near‐miss criteria. The CIPHER model did not show significant diagnostic ability (AUC 0.52) and consequently its calibration was poor (H‐L P < 0.05). The SAPS III had the best performance (AUC 0.77, H‐L P > 0.05 and SMR 0.85).ConclusionThe performance of the CIPHER model was lower compared to the other scores. Since the CIPHER model is not ready for clinical use, the SAPS III score should be considered for the prediction of SMO.
Influence of the COVID‐19 outbreak on transportation of pregnant women in an emergency medical service system: Population‐based, ORION registry
Authors: Ota Koshi , Nishioka Daisuke , Katayama Yusuke , Kitamura Tetsuhisa , Masui Jun , Ota Kanna , Nitta Masahiko , Matsuoka Tetsuya , Takasu Akira 
Published: February 2022

AbstractBackgroundThe coronavirus disease 2019 (COVID‐19), caused by Severe Acute Respiratory Syndrome Coronavirus 2, has spread rapidly across the world.ObjectiveTo assess the influence of the COVID‐19 pandemic on the emergency medical service (EMS) for transportation of pregnant women by ambulance.MethodsThis study was a retrospective, descriptive study using the Osaka Emergency Information Research Intelligent Operation Network system, and included pregnant women transported by ambulance in Osaka Prefecture between January 1, 2018 and December 31, 2020. The main outcome of the study was difficulty in obtaining hospital acceptance for transfer of patients (difficult‐to‐transfer cases). We calculated the rates of difficult‐to‐transfer cases using univariate and multivariate analyses.ResultsOf the 1 346 457 total patients transported to hospitals by ambulance in Osaka Prefecture during the study period, pregnant women accounted for 2586 (909, 943, and 734, in 2018, 2019, and 2020, respectively). Logistic regression analysis revealed that pregnant women were negatively associated with difficult‐to‐transfer cases (adjusted OR 0.36, 95% CI 0.26–0.50). Compared with 2018, 2020 was significantly associated with difficult‐to‐transfer cases (adjusted OR 1.27, 95% CI 1.24–1.30).ConclusionPregnant women were consistently associated with reduced odds for being difficult‐to‐transfer cases. The COVID‐19 pandemic might have influenced difficult‐to‐transfer cases in 2020.
Prevalence of postpartum depression in women amid the COVID‐19 pandemic: A systematic review and meta‐analysis
Authors: Safi‐Keykaleh Meysam , Aliakbari Fatemeh , Safarpour Hamid , Safari Mehdi , Tahernejad Azadeh , Sheikhbardsiri Hojjat , Sahebi Ali 
Published: February 2022

AbstractCOVID‐19 outbreaks appear to be related to exacerbation of psychological problems such as depression and anxiety in high‐risk population such as pregnant women and the postpartum period due to stress and life‐threatening illnesses. The aim of this study was to evaluate the prevalence of postpartum depression (PPD) during COVID‐19. This study protocol is registered in PROSPERO with CRD42021278425 code. Data sources including Google Scholar, ISC, Magiran, Scopus, PubMed, Embase, and Web of Science and reference list of included articles were used to identify related studies. Observational studies that reported the prevalence of PPD in both Persian and English during COVID‐19 between January 20, 2020 and August 31, 2021 were included. Data were collected and analyzed with a random effects model for meta‐analysis. In this study, 671 initial articles were identified and after removing duplicates, 454 studies were screened and finally 24 studies entered the meta‐analysis stage. According to this study results PPD based on Edinburgh Postnatal Depression Scale (EPDS) ≥9, EPDS ≥10, EPDS ≥11, EPDS ≥12, EPDS ≥13, Postpartum Depression Screening Scale‐Short Form (PDSS‐SF) ≥17 and total prevalence was reported 12% (95% confidence interval [CI] = 0.07–17,I2 = 97%), 27% (95% CI = 15–39,I2 = 99%), 44% (95% CI = 40–49,I2 = 0.0%), 27% (95% CI = 0.06–49,I2 = 97.4%), 28% (95% CI = 18–39,I2 = 98.5%), 37% (95% CI = 32–42), 28% (95% CI = 23–33,I2 = 98.5%). The findings of this study showed that the prevalence of PPD in women is relatively high during COVID‐19. Therefore, considering the psychological consequences of the COVID‐19 pandemic and the importance of pregnancy and the postpartum period in terms of the emergence of mental disorders, especially depression, it seems necessary to perform interventions and physical and psychological support.
Propranolol Promotes Bone Formation and Limits Resorption Through Novel Mechanisms During Anabolic Parathyroid Hormone Treatment in Female C57BL/6J Mice
Authors: Treyball Annika , Bergeron Audrey C. , Brooks Daniel J. , Langlais Audrie L. , Hashmi Hina , Nagano Kenichi , Barlow Deborah , Neilson Ryan J. , Roy Tyler A. , Nevola Kathleen T. , Houseknecht Karen L. , Baron Roland , Bouxsein Mary L. , Guntur Anyonya R. , Motyl Katherine J. 
Published: February 2022

ABSTRACT
Although the nonselective β-blocker, propranolol, improves bone density with parathyroid hormone (PTH) treatment in mice, the mechanism of this effect is unclear. To address this, we used a combination of in vitro and in vivo approaches to address how propranolol influences bone remodeling in the context of PTH treatment. In female C57BL/6J mice, intermittent PTH and propranolol administration had complementary effects in the trabecular bone of the distal femur and fifth lumbar vertebra (L5), with combination treatment achieving microarchitectural parameters beyond that of PTH alone. Combined treatment improved the serum bone formation marker, procollagen type 1 N propeptide (P1NP), but did not impact other histomorphometric parameters relating to osteoblast function at the L5. In vitro, propranolol amplified the acute, PTH-induced, intracellular calcium signal in osteoblast-like cells. The most striking finding, however, was suppression of PTH-induced bone resorption. Despite this, PTH-induced receptor activator of nuclear factor κ-B ligand (RANKL) mRNA and protein levels were unaltered by propranolol, which led us to hypothesize that propranolol could act directly on osteoclasts. Using in situ methods, we found Adrb2 expression in osteoclasts in vivo, suggesting β-blockers may directly impact osteoclasts. Consistent with this, we found propranolol directly suppresses osteoclast differentiation in vitro. Taken together, this work suggests a strong anti-osteoclastic effect of nonselective β-blockers in vivo, indicating that combining propranolol with PTH could be beneficial to patients with extremely low bone density. © 2022 American Society for Bone and Mineral Research (ASBMR).
Admissions data as predictors for student performance in restorative dentistry
Authors: Watrous Olivia , Grieco Peter , Aldosari Muath , Park Sang 
Published: February 2022

AbstractIntroductionThe purpose of the study was to determine the relative predictive power of admissions criteria and predoctoral academic performance in the area of restorative dentistry in order to better understand and guide the dental school admissions process.MethodsIn addition to admissions criteria, student performance in restorative dentistry, such as the Final Restorative Treatment course, the didactic and preclinical examinations, and the objective structured clinical examinations (OSCE), was measured for the 172 predoctoral students representing the graduating classes of 2017–2021.ResultsThe association between the didactic score in restorative dentistry and grade point average (GPA, p = 0.009) and Dental Admission Test (DAT, p = 0.002) score was statistically significant. Although no statistically significant association was found between preclinical scores and gender, GPA, or DAT, there was a statistically significant association between preclinical scores and the Perceptual Ability Test (PAT) score (p = 0.012). Preclinical scores included laboratory examinations for fixed prosthodontics, such as crown preparation and temporization, representing hand skills assessment. Finally, there was no statistically significant association found between the OSCE score and any of the admissions criteria.ConclusionThe dental admissions criteria could play a role in predicting academic performance in the didactic portion and preclinical component of restorative dentistry.
p‐Toluenesulfonic acid catalyzed, isocyanide‐free, Groebke–Blackburn–Bienayme (GBB) type multicomponent synthesis of 3‐anilino‐imdazo[1,2‐a]pyridines
Authors: Jalani Hitesh B. , Jeong Jin‐Hyun 
Published: February 2022

AbstractHerein, a Groebke–Blackburn–Bienayme (GBB) type multicomponent synthesis of 3‐anilinoimidazo[1,2‐a]pyridines using commercially available building blocks such as aryl glyoxal, aniline, and 2‐aminopyridine has been developed. The key advantage of this method is it avoids the use of foul‐smelling isocyanides as one of the key reaction partners in the GBB reaction. The desired products are formed via the three consecutive C–N bond formations in this one‐pot reaction demonstrated in the gram scale.
An investigation of chiral diamides as organocatalysts in asymmetric aldol reaction
Authors: Yilmaz Dilek Gul , Aydogan Feray , Yolacan Cigdem 
Published: February 2022

AbstractSeven novel proline and 1,2,3,4‐tetrahydroisoquinoline‐3‐carboxylic acid (THIQA) based diamides were synthesized successfully by simple amidation reactions and characterized by their spectral data. Their catalytic activities in asymmetric aldol reaction were performed by the reactions of aliphatic ketones and various aromatic aldehydes. Especially, (S)‐N‐((S)‐1‐(morpholinoamino)‐1‐oxo‐3‐phenylpropan‐2‐yl)pyrrolidine‐2‐carboxamide (9e) showed good catalytic activities in water at room temperature in the presence of benzoic acid cocatalyst. The enantioselectivities were upto 89.6%, the diastereomeric ratios were upto 92/8, and yields were upto 97.3%. This catalyst showed its best catalytic activities in water; this is also an important contribution to green chemistry requirements.
Microwave assisted synthesis of N‐substituted acridine‐1,8‐dione derivatives: Evaluation of antimicrobial activity
Authors: S Anil Kumar , Madderla Sarasija , Dharavath Ravinder , Nalaparaju Nagaraju , Katta Ramakrishna , Gundu Srinivas , Thumma Vishnu , B Prashanth , D Ashok 
Published: February 2022

AbstractA simple and convenient one‐pot method for the synthesis of N‐substituted acridine derivatives from the condensation of 1,3‐cyclohexanedione, substituted aryl amines, and 1,2,3‐triazole aldehydes using a mixture of water/ethanol as a reaction medium is reported. The current protocol delivers numerous advantages such as good yields, short reaction time, easy work‐up, and simplicity in the procedure as it uses a green method and an eco‐friendly catalyst. The target compounds are screened for their in vitro antimicrobial activity and most of the compounds are found to exhibit promising activity compared to standard drugs. The docking studies carried out using Autodock 4.2 were proven that all the molecules exhibited good interactions with protein glucosamine‐6‐phosphate synthase of Escherichia Coli and the secreted aspartic proteinase from Candida albicans and the docking results are in well agreement with antimicrobial activity.
Transesophageal echocardiography guided transseptal puncture and nadir temperatures in cryoballoon pulmonary vein isolation
Authors: Blockhaus Christian , Waibler Hans‐Peter , Guelker Jan‐Erik , Klues Heinrich , Bufe Alexander , Seyfarth Melchior , Koektuerk Buelent , Shin Dong‐In 
Published: February 2022

AbstractIntroductionCryoballoon (CB) guided pulmonary vein isolation (PVI) is an established procedure in the treatment of atrial fibrillation (AF). Transseptal access is an indispensable step during PVI and may be associated with severe complications. For specific interventions, specific puncture sites of the fossa ovalis are advantageous. Here, we analyzed the potential impact of a transesophageal echocardiography (TOE) guided transseptal puncture on nadir temperatures in CB PVI.Methods and ResultsWe retrospectively analyzed 209 patients undergoing CB PVI in our hospital. The use of TOE had been at the operator’s discretion. No TOE‐related complications such as perforation of the pharynx or esophagus or loss of teeth were noted. Concerning the applied freezes, we found significantly lower nadir temperatures in all PVs in the TOE group than in the non‐TOE group. Procedure time and fluoroscopy time and complications were similar in both groups.ConclusionTOE‐guided TSP in CB PVI is safe and feasible. Our study found significantly lower nadir temperatures of CB freezes after TOE‐guided TSP which potentially underscores the value of a more infero‐anterior puncture site.
Effect of superfine grinding on physical properties, bioaccessibility, and anti‐obesity activities of bitter melon powders
Authors: Zhu Ying , Bai Juan , Qian Xiwen , Yang Xue , Zhou Xinyu , Zhao Yansheng , Dong Ying , Xiao Xiang 
Published: February 2022

AbstractBACKGROUNDBitter melon is widely applied to the treatment of diabetes and obesity, but few studies focus on the processing procedure of bitter melon. The differences in physical properties, bioaccessibility, and anti‐obesity activity of bitter melon powder (BMP) produced with or without superfine grinding were investigated to optimize an effective processing procedure.RESULTSResults showed that superfine grinding could improve the physical properties of BMP, represented by greater bulk density, lower water‐holding capacity, and higher bioactive compounds’ solubilities. Superfine grinding remarkably affected the bioaccessibility of phenolics and the antioxidant capacity of bitter melon during in vitro digestion. Meanwhile, after a 4 week treatment, 25 μm BMP showed a greater anti‐obesity activity with reduction in the serum insulin levels from 16.47 to 13.10 mIU L−1, reversing high‐fat‐diet‐induced glucose intolerance, decreasing levels of serum lipids and hepatic lipid accumulation compared with the high‐fat diet group.CONCLUSIONIn conclusion, superfine grinding was beneficial for improving the physical properties and bioaccessibility, simultaneously facilitating the anti‐obesity activity of bitter melon, which will provide a reference for direct utilization of bitter melon as a health food to relieve symptoms of obesity. © 2022 Society of Chemical Industry.
Feasibility of pomelo peel dietary fiber as natural functional emulsifier for preparation of Pickering‐type emulsion
Authors: Gao Kaili , Liu Tongying , Cao Leipeng , Liu Yuhuan , Zhang Qi , Ruan Roger , Feng Shuoru , Wu Xiaodan 
Published: February 2022

AbstractBACKGROUNDThe application of Pickering emulsions stabilized by food‐derived particles is of great interest, studies have focused on development of natural functional emulsifiers from agricultural byproducts. Dietary fiber (DF) has been recognizing for its excellent physiological functions. Moreover, physicochemical properties of pomelo peel DF (PDF) make it a potential emulsifier. However, pristine PDF is not suitable as emulsifier due to its compact physical structure and high hydrophobicity, which seriously limits its utilization. The objective of the study was to investigate the effects of cellulase on physicochemical properties of PDF and to illustrate the feasibility of cellulase modified PDF (MPDF) as natural functional emulsifier.RESULTSCellulase modification significantly improved (P < 0.05) specific surface area, water‐holding capacity/oil‐holding capacity, viscoelasticity, hydrophobicity, and pore structure while decreased crystallinity index and particle size of PDF. Emulsion could remain stable over 30 days as MPDF concentrations up to 1 wt% and oil/water ratio 3:7. The appearance stability of emulsions was not influenced by temperature (4–60 °C), pH (3.0–12.0), and ion concentration (0–200 mmol L−1) which was similar to Pickering emulsions. The mechanism of MPDF as an emulsifier was mainly attributed to the combination of Pickering effect and the three‐dimensional network. In addition, MPDF showed higher antioxidant capacity in emulsions than other classical emulsifiers.CONCLUSIONThe results illustrated that MPDF has a favorable feasibility for preparation of stable Pickering‐type emulsions, which will be a practical support for application of PDF as a natural functional emulsifier and will be helpful to realize the resource utilization of DF in pomelo industries. © 2022 Society of Chemical Industry
Prediction of fumonisins B1 and B2 in corn distiller's dried grains with solubles through near‐infrared reflectance spectroscopy
Authors: Tyska Denize , Mallmann Adriano Olnei , Simões Cristina Tonial , da Silva Cristiane Rosa , Gressler Luciane Tourem , Mallmann Carlos Augusto 
Published: February 2022

AbstractBACKGROUNDDistiller's dried grains with solubles (DDGS) are coproducts of the biofuel industries that use corn as raw material. This cereal is commonly contaminated by mycotoxins, including fumonisins (FBs), which can pose a serious health threat to humans and animals. Corn DDGS are typically used as a protein‐rich animal feed. As mycotoxins from the original cereal grains become concentrated in DDGS, mycotoxicological monitoring is highly required before their use as ingredient in the industry.RESULTSThis work aimed to develop a methodology for predicting fumonisins B1 (FB1) and B2 (FB2) in corn DDGS using near‐infrared reflectance spectroscopy (NIRS) technology associated with chemometric methods. One hundred and ninety corn DDGS samples originating from Brazilian ethanol plants and feed mills were included in this assessment. Two datasets were created: one for calibration (132 samples) and another for external validation (58 samples). Partial least squares regression and a cross‐validation approach were applied to build the models. Liquid chromatography coupled to tandem mass spectrometry was used as the reference methodology. Calibration results of correlation coefficient and residual prediction deviation for FB1 and FB2 were, respectively, 0.90 and 0.88; and 2.16 and 2.06.CONCLUSIONValues of the external validation dataset were compared and no statistical difference was found between groups, indicating a satisfactory predictive ability and confirming the potential of NIRS to predict fumonisins in corn DDGS. © 2022 Society of Chemical Industry.
Artemisia selengensis Turcz. leaf extract promotes longevity and stress resistance in Caenorhabditis elegans
Authors: Li Rong , Tao Mingfang , Xu Tingting , Huang Yuting , Zogona Daniel , Pan Siyi , Wu Ting , Xu Xiaoyun 
Published: February 2022

AbstractBACKGROUNDArtemisia selengensis Turcz. (AST) is a common edible and medicinal herb possessing extensive biological activities and various health‐promoting functions. However, the anti‐aging effects of AST have been neglected. This work evaluated the effects of AST leaf extract (ASTE) on stress tolerance and longevity in Caenorhabditis elegans.RESULTSASTE treatment enhanced stress resistance and significantly extended the lifespan of C. elegans. Moreover, ASTE prolonged the healthspan by increasing body bending and pharyngeal pumping rates, and by reducing the intestinal lipofuscin level and accumulation of intracellular reactive oxygen species (ROS). Caffeoylquinic acids in ASTE, especially dicaffeoylquinic acids, were the major components responsible for these benefits. The mechanism underlying the anti‐aging effect of ASTE occurred by activating insulin/insulin‐like growth factor, SIR‐2.1 signaling and mitochondrial dysfunction pathways, which in turn induced the activity of the transcription factors DAF‐16/FOXO and SKN‐1/Nrf2.CONCLUSIONThese findings provide direct evidence for the anti‐aging effects of AST and reveal its potential on promoting healthy aging. © 2022 Society of Chemical Industry.
Tissue sample preparations for preclinical research determined by molecular imaging mass spectrometry using matrix‐assisted laser desorption/ionization
Authors: Buszewska‐Forajta Magdalena , Rafińska Katarzyna , Buszewski Boguslaw 
Published: February 2022

AbstractMatrix‐assisted laser desorption/ionization ‐ imaging mass spectrometry is an alternative tool, which can be implemented in order to obtain and visualize the “omic” signature of tissue samples. Its application to clinical study enables simultaneous imaging‐based morphological observations and mass spectrometry analysis. Application of fully informative material like tissue allows obtaining the complex and unique profile of analyzed samples. This knowledge leads to diagnosing disease, studying the mechanism of cancer development, selecting the potential biomarkers as well as correlating obtained images with prognosis. Nevertheless, it is worth noticing that this method is found to be objective but the result of the analysis is mainly influenced by the sample preparation protocol, including the collection of biological material, its preservation, and processing. However, the application of this approach requires a special sample preparation procedure. The main goal of the study is to present the current knowledge on the clinical application of matrix‐assisted laser desorption/ionization with imaging mass spectrometry in cancer research, with particular emphasis on the sample preparation step. For this purpose, several protocols based on cryosections and formalin‐fixed paraffin‐embedded tissue were compiled and compared, taking into account the measured metabolites of potential diagnostic importance for a given type of cancer.