bluuebunny/crossref_metadata_2025_split huggingface dataset:
Algorithms and Complexities of Matching Variants in Covariate Balancing
Authors: Hochbaum Dorit S. , Levin Asaf , Rao Xu 
Published: April 2022

In an observational study there are two disjointed groups of samples, one of treatment samples and the other of control samples. Each of the samples is characterized by several observed covariates. Covariate balancing problems arise when estimating causal effects using observational data. It is desirable to replicate a randomized experiment by obtaining treatment and control groups with similar covariate distributions. Even though covariate balancing problems have been studied extensively, the complexity status of many variants has not been established. Some of our results demonstrate that 2-covariate balancing problems are polynomial time solvable, whereas almost all problems are hard for three or more covariates. These results have practical implications, such as justifying the use of implicit enumeration techniques or heuristics for the hard cases. A new approach suggested by our results is to use the 2-covariate polynomial cases and relax the problem by aggregating covariates into two sets to be solved efficiently. (accepted paper title: Algorithms and complexities of matching variants in covariate balancing)
Biosecurity Education for the Next Generation
Authors: Schuft Abby , Schieck Boelke Sarah , DeWitte Diane , Martinson Krishona , Cortus Erin L. 
Published: April 2022

HighlightsYouth are agents for change in biosecurity practices.47 workshops introduced biosecurity principles to youth.The curriculum was tailored for nine animal species.Biosecurity education requires continued programming. Abstract. Biosecurity education for youth involved in animal agriculture is vital for the continued success of commerce in these industries. Biosecurity workshops were developed and delivered to youth in Minnesota to encourage positive changes, with long-term outcomes of healthier animals. Learning gains were significant for all participants, and the participants retained this knowledge over time. Most participants had good intentions of making changes because of the workshops, and follow-up survey results showed that the participants implemented changes, validating that youth are agents for behavior change. However, other indicators surfaced suggesting that continued programming is needed to encourage adoption of more biosecurity practices. Keywords: Animals, Biosecurity education, Youth.
Potency of Various MicroRNA as Sputum Biomarker in Lung Cancer
Authors: Alnaz Ahmad Razi Maulana , Abdillah Aqyl Hanif , Ridha Rasyid 
Published: April 2022

<p class="AbstractNormal"><strong>Introduction: </strong>Lung cancer is one the deadliest cancer known. Current method using low-dose CT scan to screen lung cancer applied are proved to reduce mortality, but lack in accuracy leading to overdiagnosis. Current researches are mostly seeking for a non-invasive and cost-effective method, hence biomarkers such as microRNA has a potency to screen and diagnose lung cancer. This literature review aimed to discuss the potency of microRNA in sputum as a biomarker in screening lung cancer.</p><p class="AbstractNormal"><strong>Methods:</strong><strong> </strong>The study is conducted by literature searching for related journals in search engines such as PubMed, Science Direct, and Google Scholar with keywords. 35 articles were included with relevance and within 10 years publication.</p><p class="AbstractNormal"><strong>Result:</strong><strong> </strong>MicroRNA is a short non-coding RNA which regulates gene expression. It acts in an oncogene or tumor suppressor gene regulation. DNA mutations or defects occurred in cancer particularly in lung cancer causes increase or decrease of microRNA expression. Alterations of microRNA expression in sputum detected by rt-PCR may represent progressions of lung cancer from a cell cycle dysregulation and provides better sensitivity and specificity among other biomarkers. Combinations of miRNA species offer increase of sensitivity and specificity. Particular types of microRNA are able to classify the types of lung cancer in progress.</p><p><strong>Conclusion: </strong>MicroRNA has the promising potency and strong accuracy with a non-invasive and cost-effective procedure in detecting early signs of lung cancer occurrence and can be further applied as biomarker used in lung cancer.</p><p>Keywords: Biomarker; Lung Cancer; microRNA; Screening; Sputum</p>
Novos registros de Geastraceae Corda para o Nordeste brasileiro
Authors: Leite Anileide G. , Baseia Iuri Goulart 
Published: April 2022

The present study deals with the occurrence of Geastraceae from Atlantic Rainforest and Caatinga biomes in the region encompassed by the states of Rio Grande do Norte and Pernambuco. Four species have been identified: Geastrum saccatum, G. schweinitzii, G. triplex and Myriostoma coliforme, all of them representing new records from Rio Grande do Norte. The material collected was added to the herbarium URM and UFRN-fungi. Descriptions of macro and microscopic features are given, including taxonomic and ecological comments.
Conhecimento de pescadores artesanais sobre a composição da avifauna em estuários paraibanos: uma contribuição para a conservação
Authors: Araujo Helder Farias Pereira de , Nishida Alberto Kioharu 
Published: April 2022

Studies on animal diversity and ecology provide practical information necessary for the conservation and management of ecosystems, and can indicate contamination pathways as well as environmental transformations. However, avifauna studies in such endangered environments as mangroves are not very common. In an ethnoornithological context, this work has evaluated the knowledge of the local population in relation to the composition of avifauna in estuaries of Paraíba River and Mamanguape River, in state of Paraíba. Ethnobiological methods, together with estimative of species richness methods and comparisons with similarity tests, were used to demonstrate how the avifauna recorded for area was known by local population. Informers have mentioned 94 species of birds. Coefficients of Jaccard and Sorensen, with values of 0.617 and 0.763 respectively, demonstrate a considerable similarity between the composition of the avifauna known by the local population and the one recorded. Distribution of the knowledge was evaluated in relation to the communities’ social aspects. The results and methodology employed have expressed contributions and discussions about practical evaluations for conservation.
STUDY OF EXTRUSIVE CHEMICAL THERMOMECHANICAL PULP
Authors: Koverninskij Ivan Nikolaevich , Duboviy Vladimir Kliment'yevich , Prokopenko Kirill Dmitriyevich 
Published: April 2022

The article presents the results of a study of extrusive chemical-thermomechanical pulp (ECTMP) from bleached poplar wood. As a result of the study, it was established:
Microscopic studies of the ECTMP fiber confirm the mechanism of predominant fibrillation of wood along the S layer.
The medium- and long-fiber fraction of ECTMP is 85–80%, with a grinding degree of 24–43°. This fact confirms the small shortening of the fiber with an increase in the degree of grinding by more than 20°.
For use in the composition of paper and cardboard, it is recommended to grind ECTMM to the limits of 35–45°.
Freezing ECTMP, like drying, reduce physical and mechanical properties within 10-15%. It is recommended, if possible, to recycle ECTMP immediately after receipt, without drying or freezing.
ECTMP is a pulp and paper fibrous semi-finished product suitable for use in the composition of many types of paper and cardboard.
A systematic review of the effects of laughter on blood pressure and heart rate variability
Authors: Oliveira Raquel , Arriaga Patrícia 
Published: April 2022

Abstract
In this systematic review, we sought to understand the effects of laughter-inducing interventions on blood pressure and heart rate variability. For this purpose, we identified 32 relevant records through database searching. The results suggest that laughter is associated with a decrease in blood pressure in pre–post measurements. However, this association varies according to the type of intervention delivered and the characteristics of participants. In controlled between-groups comparisons, the effect of laughter-inducing interventions on blood pressure was found to be non-significant, which can be due to the small number of studies available and its high level of heterogeneity. In studies involving heart rate variability, the most consistent findings point to an association between laughter and decreases in both frequency (LF/HF) and time-domain (SDNN) indicators. Longitudinal studies suggest that laughter frequency is associated with improved cardiovascular health. Several studies presented sub-optimal levels of quality, and more research is necessary to examine the impact of individual and intervention-related factors in the effectiveness of laughter-inducing interventions in cardiovascular health.
Borrowing historical information for non-inferiority trials on Covid-19 vaccines
Authors: De Santis Fulvio , Gubbiotti Stefania 
Published: April 2022

Abstract
Non-inferiority vaccine trials compare new candidates to active controls that provide clinically significant protection against a disease. Bayesian statistics allows to exploit pre-experimental information available from previous studies to increase precision and reduce costs. Here, historical knowledge is incorporated into the analysis through a power prior that dynamically regulates the degree of information-borrowing. We examine non-inferiority tests based on credible intervals for the unknown effects-difference between two vaccines on the log odds ratio scale, with an application to new Covid-19 vaccines. We explore the frequentist properties of the method and we address the sample size determination problem.
MicroRNAs in cardiovascular diseases
Authors: Li Huaping , Zhan Jiabing , Chen Chen , Wang Daowen 
Published: April 2022

Abstract
Cardiovascular diseases (CVDs) are the leading causes of death and disability worldwide, despite the wide diversity of molecular targets identified and the development of therapeutic methods. MicroRNAs (miRNAs) are a class of small (about 22 nucleotides) non-coding RNAs (ncRNAs) that negatively regulate gene expression at the post-transcriptional level in the cytoplasm and play complicated roles in different CVDs. While miRNA overexpression in one type of cell protects against heart disease, it promotes cardiac dysfunction in another type of cardiac cell. Moreover, recent studies have shown that, apart from cytosolic miRNAs, subcellular miRNAs such as mitochondria- and nucleus-localized miRNAs are dysregulated in CVDs. However, the functional properties of cellular- and subcellular-localized miRNAs have not been well characterized. In this review article, by carefully revisiting animal-based miRNA studies in CVDs, we will address the regulation and functional properties of miRNAs in various CVDs. Specifically, the cell–cell crosstalk and subcellular perspective of miRNAs are highlighted. We will provide the background for attractive molecular targets that might be useful in preventing the progression of CVDs and heart failure (HF) as well as insights for future studies.
Broadband nonlinear optical modulator enabled by VO2/V2O5 core–shell heterostructures
Authors: Chen Longlong , Huang Jing , Li Ning , Zhu Hao , Hu Jianbang , Miao Lili , Zhao Chujun 
Published: April 2022

Abstract
Broadband pulsed lasers have become an indispensable part in optical communications, biomedical engineering, materials processing, and national defense. Inspired by the broadband and ultrafast optical components, great efforts from the laser and material community have been paid to explore the emerging nonlinear optical materials. Here, we found that the VO2/V2O5 core–shell heterostructures with type-II staggered band alignment exhibit broadband nonlinear optical response towards mid-infrared spectral range. The nonlinear optical characterizations verify that the heterostructures show the modulation depth and saturation intensity of 27% and 42 GW/cm2 at 1064 nm, 23% and 78 GW/cm2 at 1550 nm, and 16.5% and 63.9 GW/cm2 at 2800 nm, respectively. With the nonlinear optical modulator, stable mode-locked Yb-doped and Er-doped fiber lasers have been realized with pulse output as short as 310 ps and 633 fs, respectively. In addition, the stable Q-switched Er-doped fluoride fiber laser has been demonstrated with a pulse repetition rate of 89 kHz and the shortest pulse width of 680 ns, respectively. The experimental results indicate that VO2/V2O5 core–shell heterostructures can be broadband nonlinear optical modulators from the near-infrared to the mid-infrared spectral range, offering opportunities to develop high-performance photonic devices.
Hebrew ḥāṭā’ in the G-Stem: »to Miss« or »to Sin«?
Authors: Clifford Richard 
Published: April 2022

Abstract
There are passages in the Hebrew Bible in which the translation of the Hebrew G-stem verb ḥāṭā’ as »to miss, fail to attain« makes better sense than its otherwise dominant meaning »to sin.« Though modern Hebrew lexica allow for the occasional meaning of »to miss,« many modern translations fail to consider »to miss« and insist on »to sin.« The article examines eleven instances in the Bible where »to miss, fail to attain,« makes better sense than the traditional »to sin,« especially in the Wisdom literature.
Balance Confidence and Balance Performance, But Not Fall History Are Associated With Quality of Life in Community-Dwelling Older Adults: A Cross Sectional Study
Authors: Roberts Holly J. , Johnson Kristen M. , Sullivan Jane E. , Hoppes Carrie W. 
Published: April 2022

Background and Purpose:
Fear of falling (FoF) is highly prevalent in community-dwelling older adults and is associated with low health-related quality of life (QoL). Low QoL is associated with increased health care utilization and is a predictor of future falls, but few studies have examined the relationship between high-level balance and dynamic gait performance and QoL in community-dwelling older adults. The purpose of this cross-sectional study was to determine whether there is a relationship between FoF avoidance behaviors, balance confidence, performance on measures of high-level mobility, and QoL in community-dwelling older adults. The secondary purpose was to determine whether older adults who fall have a different QoL than older adults who have not fallen in the past year.

Methods:
Eighty-nine community-dwelling older adults (76.33 ± 6.84 years, 54 female, 34 fallers) completed the World Health Organization Quality of Life-BREF (WHOQOL-BREF), Activities-specific Balance Confidence Scale (ABC), Fear of Falling Avoidance Behavior Questionnaire (FFABQ), Functional Gait Assessment (FGA), and Community Balance and Mobility Scale (CB&M). Correlation and multiple regression analyses were calculated to determine the relationship between the outcome measures and domains on the WHOQOL-BREF.

Results and Discussion:
Significant correlations were observed between the WHOQOL-BREF physical health domain and the ABC, FFABQ, FGA, and CB&M (ρ= 0.524, −0.509, 0.348, and r = 0.423, respectively), the WHOQOL-BREF psychological domain and the ABC (ρ= 0.284) and FFABQ (ρ=−0.384), and the WHOQOL-BREF environment domain and the ABC (ρ= 0.343) and FFABQ (ρ=−0.406). No correlations were found between WHOQOL-BREF domain scores and a history of falls.

Conclusions:
Performance-based outcome measures that measure high-level mobility such as the CB&M and FGA, and patient-reported outcome measures for balance confidence and FoF avoidance behavior such as the ABC and FFABQ, are correlated with the physical health QoL domain on the WHOQOL-BREF. The ABC and FFABQ are correlated with psychological and environment QoL. Fall history was not correlated with QoL. Interventions to decrease FoF or improve high-level mobility may improve QoL in community-dwelling older adults.
Perioperative Safety Evaluation of Gastrointestinal Surgery in Patients With Prosthetic Valves
Authors: Chen Ling , Sun Jie , Chen Hao , Liu Fenglin 
Published: April 2022

Background: In patients with prosthetic valves, the perioperative outcomes, as well as the risk factors, following gastrointestinal surgery remain to be defined.
Methods: From January 2010 to March 2018, the clinical data of 69 cases with prosthetic valves after gastrointestinal surgery retrospectively were collected. Univariate and multivariate analysis were applied to identify the risk factors associated with significant bleeding events and non-hemorrhagic complications.
Results: Among 69 cases, 9 patients (13.0%) presented major bleeding events, and 21 patients (30.4%) presented non-hemorrhagic complications. Major bleeding events were significantly higher in patients with simple aortic valve replacement (AVR) than in other types of prosthetic valves (27.6% vs. 2.5%, P = 0.003), and there was no significant difference in the incidence of non-hemorrhagic complications. Simple AVR was the significant risk factor for major bleeding events (P = 0.043). Significant risk factors for non-hemorrhagic complications were operative duration ≥ 160 minutes (P = 0.021), duration from heart valve replacement to gastrointestinal surgery ≥ 84 months (P = 0.039), and simple AVR (P = 0.047).
Conclusion: The patients with simple AVR had a much higher bleeding risk following gastrointestinal surgery.
Cinema perspectivista: Resenha do Filme “A Fevre”
Authors: Rique Fernandes Mario , Henrique Soares Guilherme , Fonseca Câmpera Luiza Maria , Sanches Barreto Silvio 
Published: April 2022

“A Febre”; La fiebre; The fever. Direção: Maya Da-Rin. Elenco: Regis Myruou, Rosa Peixoto, Edmildo Vaz Pimentel, Lourinelson Vladmir, Johnatan Sodré. Drama /98 min/Brasil, França, Alemanha
Editorial
Authors: Márcio Cruz Paulo 
Published: April 2022

Se presenta el Volumen 16 (2) de la Revista Jurídicas de la Universidad de Caldas - Colombia. La produccióncientífica presentada en este volumen fue el resultado de los estudios realizados a través del Acuerdo de Doble Maestría existente entre la Universidad de Caldas / Colombia y la Universidad de Vale do Itajaí SC / Brasil.
La colección se centra, como sugiere el título en sí, en cuestiones que afectan a la “Democracia, Constitucionalismo, Gobernanza y Sostenibilidad”. Habiendo hecho estas consideraciones preliminares, es importante mencionarlos textos que componen este trabajo y también a sus autores.
Extradición y derecho internacional en contextos de conflicto armado no internacional: el caso de Edwar Cobo Téllez ante la Corte Suprema de Justicia de Colombia
Authors: Merlano Sierra Javier E. , Rojas Hernández Belkis 
Published: April 2022

El derecho internacional y la cooperación internacional en materia penal expresan la demanda creciente de la participación conjunta de los Estados en la aplicación de justicia, proponiendo el diseño de mecanismos que garanticen la lucha contra la impunidad frente a asuntos de trascendencia para la comunidad internacional. En este entendido, nos cuestionamos si: ¿aplica la Corte Suprema de Justicia de Colombia el Derecho Internacional, al conceptuar sobre la extradición de perpetradores de violaciones de los derechos humanos y del Derecho Internacional Humanitario asociados al conflicto armado interno? Analizamos para ello el asunto de alias Diego Vecino - Autodefensas Unidas de Colombia. Este artículo de reflexión aporta fundamentos teóricos que faciliten conceptuar con carácter vinculante acerca de la extradición o no de jefes de grupos armados al margen de la ley, considerando la necesidad de garantizar principios de verdad, de justicia y de reparación, orientados a la solución del conflicto armado en Colombia.
Nodal Seismic Experiment at the Berkeley Section of the Hayward Fault
Authors: Taira Taka’aki , Dreger Douglas S. , Allam Amir A. 
Published: April 2022

AbstractThe Hayward fault (HF) in the San Francisco Bay area of California is one of the most hazardous faults of the San Andreas fault system with a total length of 70 km. In November 2020, we conducted a dense array experiment that deployed 182 three-component nodal sensors for about a five-week period at the Berkeley section of the HF. Our primary goal of this experiment was to image the seismic velocity structure in the upper crust of this area to better understand the fault-zone structure and its elastic properties. A linear array (10 stations with 5–10 m spacing) was deployed on the north side of University of California, Berkeley Memorial Stadium where the HF runs underneath, together with 27 stations that were installed surrounding the stadium. Here we detail our scientific motivation, station metadata, and quality of seismic waveforms. We also show initial results of fault-zone guided waves observed from the linear array and provide first-step results of Green’s functions between nodal stations obtained by an ambient noise cross-correlation analysis.
PENGEMBANGAN MULTIMEDIA INTERAKTIF BERBASIS ANIMASI “ADOBE FLASH PROFESSIONAL CS6” UNTUK MENINGKATKAN KETERTARIKAN SISWA SMP NEGERI 1 KALIBARU TERHADAP PEMBELAJARAN SENI RUPA
Authors: Pratiwi Anggia Erdi , Iriaji Iriaji , Prasetyo Abdul Rahman 
Published: April 2022

Pengembangan multimedia interaktif berbasis animasi ini adalah bentuk media pembelajaran interaktif yang memiliki beberapa unsur seperti teks, audio, video, animasi, dan gambar yang proses pembuatannya dari aplikasi adobe flash professional cs6. Tujuan dari pengembangan media interaktif ini yaitu agar menjadi varian baru dalam menyampaikan pembelajaran secara efektif dan lebih beragam sesuai perkembangan media digital saat ini. Penelitian pengembangan ini menggunakan model pengembangan ADDIE (Analysis, Design, Develop, Implement, dan Evaluate) yang sudah dimulai sejak tahun 1990-an yang dikembangkan oleh Dick dan Carry. Dalam analis penelitian subjek yang diambil adalah perwakilan siswa SMPN 1 Kalibaru kelas VII ,VIII dan IX , serta mengambil hasil validasi dari ahli media bidang animasi dari dosen dan mahasiwa teknologi informasi dari STIKOM Banyuwangi dan ahli materi dari guru seni budaya SMPN 1 Kalibaru. Oleh karena itu media pembelajaran animasi tersebut sudah layak dipergunakan sebagai media bahan ajar di SMPN 1 Kalibaru dengan hasil validasi yang telah dilakukan dan masuk syarat ketentuan yang telah disetujui oleh pihak sekolah yang terkait. Kata kunci: multimedia interaktif, seni budaya , pengembangan model IDDIE, validasi
Learning Arduino as a Simple River Water Level Detection System Based on Ultrasonic Sensors
Authors: Purwandani Bertha Anggita , Lianny Dimitra Ega , Anggraeni Melani Fitri , Fauziah Putri , Pramono Nugroho Adi , Hartawan Rahmat 
Published: April 2022

Current technological advancements are rapidly and impact daily life. Developing technology can be applied in many programs, one of which is as a tool for education. As shown in this study, technology as a mode of learning can be implemented in daily life. This study examined Arduino programming to create a river water level detection system using an ultrasonic sensor. This research is expected to be used as a learning tool for using Arduino as a microcontroller and can be applied in daily life. Additionally, by developing this river water level detection system, it will be possible to mitigate flood disasters.