bluuebunny/crossref_metadata_2025_split huggingface dataset:
Accuracy and prognostic impact of FDG PET/CT and biopsy in bone marrow assessment of follicular lymphoma at diagnosis: A Nation‐Wide cohort study
Authors: Ródenas‐Quiñonero Isabel , Chen‐Liang Tzu , Martín‐Santos Taida , Salar Antonio , Fernández‐González Marta , Celades Carolina , Navarro José‐Tomás , Martínez‐Garcia Ana Belén , Andreu Rafael , Balaguer Aitana , Martin García‐Sancho Alejandro , Baile Mónica , López‐Jiménez Javier , Marquet‐Palomanes Juan , Teruel Ana Isabel , Terol María José , Benet Carmen , Frutos Laura , Navarro José Luis , Uña Jon , Suarez Marina , Cortes Montserrat , Contreras José , Ruiz Cristina , Tamayo Pilar , Mucientes Jorge , Sopena‐Novales Pablo , Reguilón‐Gallego Laura , Sánchez‐Blanco José Javier , Pérez‐Ceballos Elena , Jerez Andrés , Ortuño Francisco José 
Published: November 2022

AbstractBackgoundIn the workup of follicular lymphoma (FL), bone marrow biopsy (BMB) assessment is a key component of FLIPI and FLIPI2, the most widely used outcome scores. During the previous decade, several studies explored the role of FDG‐PET/CT for detecting nodal and extranodal disease, with only one large study comparing both techniques.MethodsThe aim of our study was to evaluate the diagnostic accuracy and the prognostic impact of both procedures in a retrospective cohort of 299 FL patients with both tests performed at diagnosis. In order to avoid a collinearity bias, FLIPI2 was deconstructed in its founding parameters, and the bone marrow involvement (BMI) parameter separately included as: a positive BMB, a positive PET/CT, the combined “PET/CT and BMB positive” or “PET/CT or BMB positive”. These variables were also confronted independently with the POD24 in 233 patients treated with intensive regimens.ResultsIn the total cohort, bone marrow was involved in 124 and 60 patients by BMB and PET/CT, respectively. In terms of overall survival, age > 60 y.o. and the combined “PET/CT or BMB positive” achieved statistical independence as a prognostic factor. In patients treated with an intensive regimen, only the combined “PET/CT or BMB positive” added prognostic value for a shorter overall survival, when confronted with the POD24.ConclusionOur results show that in FL both BMB and PET/CT should be considered at diagnosis, as their combined assessment provides independent prognostic value in the context of the most widely use clinical scores.
Silica‐supported Catalyst System Rh−Mn−Ir−Li−Ti in Syngas to Ethanol Reaction: Reactivity Trends and Performance Optimization
Authors: Khatamirad Mohammad , Konrad Martin , Gentzen Manuel , Almer Christian , Boscagli Chiara , Bottke Nils , Geske Michael , Rosowski Frank , Kraehnert Ralph 
Published: November 2022

AbstractEthanol is a high‐value chemical that can be produced from syngas derived from fossil or renewable resources. Silica‐supported catalysts based on Rh are reported to show the best performance so far. We report a comprehensive investigation for influence of catalyst composition on performance in syngas conversion to ethanol. We evaluate 53 different silica‐supported catalysts with a varying degree of Rh, Mn, Ir, Li and Ti, via high‐throughput testing. Correlation analysis reveals that Li and Ir tend to increase the selectivity to C2+ oxygenates, and catalysts with a 0.95 molar ratio of Rh : Mn show a tendency for high CO conversion. The composition 2.8Rh, 0.45Mn, 1.3Ir, 0.04Li, where the numbers indicate weight percentage, is identified to yield one of the highest C2+ oxygenate values reported in the literature so far. Moreover, combining this catalyst with a hydrogenation catalyst and converting C2+ oxygenates to ethanol, provides one of the highest ethanol yields reported so far in literature.
Selective Oxidation of Methane into Formic Acid over ZIF‐8‐Encapsulated Mononuclear Fe Species under Mild Conditions
Authors: Lin Lu , Zhang Guikai , Kang Liqun , Yu Tao , Su Yang , Zeng Guang , Chu Shengqi , Luo Wenhao 
Published: November 2022

AbstractThe direct catalytic oxidation of methane into C1 oxygenates is a promising approach for methane valorization. However, the difficulties in CH4 activation and inhibition of over‐oxidation hinder the development of efficient catalysts for this transformation. Herein, highly dispersed Fe species confined by ZIF‐8 are developed for the direct transformation of methane into value‐added C1 oxygenates with H2O2 as oxidant at 323 K. The as‐obtained Fe‐ZIF‐8 can afford an optimal turnover rate (TOR) of ∼45 molC1 molFe−1 h−1. Note that the selectivity to HCOOH is ∼97 %, outstanding among the reported Fe‐based heterogeneous catalysts. Combined analysis of X‐ray photoelectron spectroscopy, X‐ray absorption spectroscopy, ultraviolet‐visible diffuse reflectance spectroscopy and 57Fe Mössbauer spectroscopy suggests that the catalytically active sites in Fe‐ZIF‐8 are mononuclear six‐coordinated Fe3+ species. The confinement of mononuclear Fe species within a porous metal‐organic framework material can provide an exquisite, enzyme‐like performance for highly selective oxidation of methane towards formic acid under mild conditions.
Survey on compressed sensing reconstruction method for3Ddata
Authors: Zhang Jingbo , Xie Liping 
Published: November 2022

SummaryThe information society has higher and higher requirements for the collection, transmission and storage of digital signals, and signal utilization efficiency has become an increasingly important part of the digital signal processing process. The traditional digital signal processing needs to satisfy the Nyquist sampling theorem to ensure the restoration of the signal, while the digital signal processing method based on compressed sensing can sample and reconstruct the signal under the conditions that much lower than the Nyquist sampling theorem. Undoubtedly, the utilization efficiency of digital signals has been greatly accelerated. In this article, taking hyperspectral images and videos as examples, we review the basic theory, reconstruction model, and reconstruction algorithm of 3D data compressed sensing. We analyze, summarize, and discuss the existing literature. Finally, the research status of compressive sensing reconstruction methods for hyperspectral images and videos is compared, and several important research directions for compressive sensing reconstruction of 3D data in the future are proposed.
Lipophilic N‐Hydroxyimide Derivatives: Design, Synthesis, and Application to Aerobic Alkane Oxidation Under Neat Conditions
Authors: Kaneiwa Takaya , Yamada Kaito , Nakano Ryo , Yamashita Makoto 
Published: November 2022

AbstractThis work reports the design and synthesis of a series of 5‐membered and 6‐membered N‐hydroxyimides flanked by lipophilic alkyl groups adjacent to carbonyl groups, aiming to endow lipophilicity and tolerance toward ring opening degradation. Their solubility in cyclohexane was 5–20 times higher than those of unsubstituted N‐hydroxyphthalimide (NHPI) and even 3–10 times higher than a formerly known lipophilic NHPI analog bearing a long alkyl ester. UV‐Vis spectroscopy determined the rate constants of first‐order decay of N‐oxyls, which revealed enhanced stability of 3,5‐di‐tert‐butyl‐NHPI and N‐hydroxyglutarimide flanked by spiro‐cyclohexanes compared with that of NHPI. Their bond dissociation energies were assessed by EPR spectroscopy and DFT calculation, suggesting these lipophilic N‐hydroxyimides catalyzed aerobic cyclohexane oxidation under neat conditions with up to 60 turnovers, which is the highest among hitherto reported reactions under neat conditions.
Revisiting the Fluorescence of Benzothiadiazole Derivatives: Anti‐Kasha Emission or Not?
Authors: Veys Koen , de Jong Flip , Adriaens Annelies , Coenen Gitte , Coenen Kylie , De Ligt Yvonne , Meysman Quinten , Paredis Trijntje , Stalmans Jesse , Dehaen Wim , Van der Auweraer Mark , Escudero Daniel 
Published: November 2022

AbstractIn this paper we revisit the fluorescent properties of two fluorophores, namely N‐butyl‐7‐(4‐ methoxyphenyl)‐2,1,3‐benzothiadiazole‐4‐amine (1) and 4‐[[7‐(4‐methoxyphenyl)‐2,1,3‐ benzothiadiazole‐4‐yl]amino]‐benzonitrile (2), whose emissive and fluorescent sensing properties were recently investigated by Peng et al. in Ref. [1]. Experimentally, these two fluorophores were reported to show excitation wavelength‐dependent emission properties, especially 1, which is a dual emitter. The authors of the original manuscript ascribed the excitation‐wavelength‐dependent emission properties to an emission from a higher‐lying excited state (i. e. anti‐Kasha emission). Our investigations, including steady‐state spectroscopy, lifetime measurements and time‐dependent density functional theory and second‐order algebraic diagrammatic construction [ADC(2)] calculations, unambiguously highlight that the fluorophores do not violate Kasha's rule but reveal instead that a protonated species is responsible for the higher‐lying emissive band. In addition, we have elucidated the actual fluorescent pH sensing mechanisms. More and more molecular systems are reported to violate Kasha's rule; sometimes without compelling proof. This study highlights the need to i) exhaustively investigate apparent anomalous cases reported in the literature that seemingly violate Kasha's rule and ii) propose good scientific practices to correctly assign anomalous photochemical events.
Science and RE teachers' perspectives on the purpose of RE on the secondary school curriculum in England
Authors: Woolley Mary , Bowie Robert A. , Hulbert Sabina , Thomas Caroline , Riordan John‐Paul , Revell Lynn 
Published: November 2022

AbstractRenewed interest in curriculum in English schooling over the past decade has emanated from a particular focus on the place and role of knowledge in the classroom. Significant changes in policy and examination specifications have led to changes in religious education (RE). However, little is known about teachers' perspectives on the purpose of RE. We asked teachers of science and RE what they understood as the purpose of RE on the school curriculum. Data from 10 focus groups and a survey with 276 secondary teachers demonstrated that many secondary teachers of science have a different understanding to RE teachers of the purpose of RE on the school curriculum. Findings also show a lack of consensus from RE teachers on the purpose of RE, suggesting the impact of the knowledge turn in RE is not as strong as the Ofsted Research Review implies. Findings are significant as little is known about how knowledge works across disciplinary boundaries in schools. If students are to come to a full understanding of how knowledge works, teachers need to have some understanding of how knowledge is being constructed and utilised in other curriculum subjects. Knowledge of the intended purpose of RE is important for respectful co‐existence of subjects on the curriculum and essential when RE is declining as a subject in secondary schools.
The record of sea water chemistry evolution during the Ediacaran–Cambrian from early marine cements
Authors: Xiong Yi , Wood Rachel , Pichevin Laetitia 
Published: November 2022

AbstractThe Ediacaran–Cambrian Radiation marks the widespread appearance of metazoans and calcareous biomineralised hard parts. These innovations occurred during an interval of dynamic changes in marine redox and sea water chemistry. Here, changing carbonate mineralogy, Mg/Ca ratios and rare earth element concentrations including the relative abundance of cerium (Ce anomaly: Ceanom) are documented to track sea water oxygen levels, in well‐preserved early marine cements from shallow marine reefs from Cambrian Stages 2–4 (ca 525–512 Ma). First, integrating the mineralogical data with published records, several shifts in dominant carbonate mineralogy are inferred: ‘dolomite‐aragonite seas’ in the late Ediacaran; ‘aragonite/high‐Mg calcite seas’ in Cambrian Stage 2; a temporary shift to a ‘calcite sea’ during early Cambrian Stage 3; an ‘aragonite sea’ between late Cambrian Stage 3 and late Cambrian Stage 4, then a gradual shift from mixed ‘aragonite–calcite seas’ during the middle and upper Cambrian towards a ‘calcite sea’ by the early Ordovician. Second, based on measured mMg/Ca in early marine cements, calculated sea water mMg/Ca at 15 and 35°C ranges from 1.2 to 0.8 in Cambrian Stage 2, 0.7–0.4 in Stage 3 and 1.4–0.9 in Stage 4 respectively. Finally, analysed Ceanom data combined with existing Ceanom data suggest potentially three phases of global oxic expansion. First, a long‐lived phase of progressive oxygenation during the late Ediacaran to Fortunian (ca 550–540 Ma; average Ceanom from 0.99 to 0.41), and possibly two shorter phases during early Cambrian Stage 3 (ca 519 Ma; average Ceanom from 0.91 to 0.40) and Stage 4 (ca 512 Ma; average Ceanom from 1.02 to 0.49), bounded by intervals of more dominant anoxia. Summarising, these data demonstrate that early marine cements offer an underused and high‐resolution archive of shallow marine redox and sea water chemistry through this critical transition in Earth's evolution.
Excitatory and inhibitory neuron imbalance in the intrauterine growth restricted fetal guinea pig brain: Relevance to the developmental origins of schizophrenia and autism
Authors: Cumberland Angela , Hale Nadia , Azhan Aminath , Gilchrist Courtney P. , Chincarini Ginevra , Tolcos Mary 
Published: November 2022

AbstractNeurodevelopmental disorders such as schizophrenia and autism are thought to involve an imbalance of excitatory and inhibitory signaling in the brain. Intrauterine growth restriction (IUGR) is a risk factor for these disorders, with IUGR onset occurring during critical periods of neurodevelopment. The aim of this study was to determine the impact of IUGR on excitatory and inhibitory neurons of the fetal neocortex and hippocampus. Fetal brains (n = 2) were first collected from an unoperated pregnant guinea pig at mid‐gestation (32 days of gestation [dg]; term ∼67 dg) to visualize excitatory (Ctip2) and inhibitory (calretinin [CR] and somatostatin [SST]) neurons via immunohistochemistry. Chronic placental insufficiency (CPI) was then induced via radial artery ablation at 30 dg in another cohort of pregnant guinea pigs (n = 8) to generate IUGR fetuses (52 dg; n = 8); control fetuses (52 dg; n = 7) were from sham surgeries with no radial artery ablation. At 32 dg, Ctip2‐ and CR‐immunoreactive (IR) cells had populated the cerebral cortex, whereas SST‐IR cells had not, suggesting these neurons were yet to complete migration. At 52 dg, in IUGR versus control fetuses, there was a reduction in SST‐IR cell density in the cerebral cortex (p = .0175) and hilus of the dentate gyrus (p = .0035) but not the striatum (p > .05). There was no difference between groups in the density of Ctip2‐IR (cortex) or CR‐IR (cortex, hippocampus) neurons (p > 0.05). Thus, we propose that an imbalance in inhibitory (SST‐IR) and excitatory (Ctip2‐IR) neurons in the IUGR fetal guinea pig brain could lead to excitatory/inhibitory dysfunction commonly seen in neurodevelopmental disorders such as autism and schizophrenia.
The effectiveness of lived experience involvement in eating disorder treatment: A systematic review
Authors: Pellizzer Mia L. , Wade Tracey D. 
Published: November 2022

AbstractObjectiveThis systematic review sought to understand the effectiveness of lived experience mentoring, by people recovered from an eating disorder, with clinical samples currently receiving eating disorder treatment.MethodsThe systematic review was conducted using PsycINFO, MEDLINE, Scopus, and ProQuest Dissertations and Theses Global and reviewing reference lists of included papers. Articles were included if they: (1) were intervention studies that included peer (recovered from an eating disorder) involvement, (2) delivered the intervention to clinical samples (or carers with direct involvement in treatment), (3) were in English, and (4) included quantitative results.ResultsEleven studies were included across randomized control trials (RCTs), case series, and a case study; there was variation in quality. Findings varied considerably with some concluding that lived experience mentoring led to significant improvements for mentees, while other studies found no significant differences. Mentor outcomes were often not evaluated. Of those that did assess mentors, there is preliminary evidence for some benefits to participation but also the potential for harm.DiscussionThere is a need for further research in this area using high‐quality RCTs that address the risk of bias. It is important that lived experience peer mentors are monitored on key outcomes, provided with adequate training and ongoing supervision, and are reimbursed for their involvement.Public SignificanceThis systematic review is the first review to focus on the use of peer mentors recovered from an eating disorder contributing to interventions for people receiving treatment for an eating disorder. All included studies present quantitative results. Given the emerging interest of lived experience mentoring, understanding its effectiveness for both mentees and impacts on mentors continues to be of critical importance.
Soil microbial legacies influence plant survival and growth in mine reclamation
Authors: McMahen Katie , Guichon Shannon H. A. , Anglin C. D. , Lavkulich Les M. , Grayston Susan J. , Simard Suzanne W. 
Published: November 2022

AbstractPlants alter soil biological communities, generating ecosystem legacies that affect the performance of successive plants, influencing plant community assembly and successional trajectories. Yet, our understanding of how microbe‐mediated soil legacies influence plant establishment is limited for primary successional systems and forest ecosystems, particularly for ectomycorrhizal plants. In a two‐phase greenhouse experiment using primary successional mine reclamation materials with or without forest soil additions, we conditioned soil with an early successional shrub with low mycorrhizal dependence (willow, Salix scouleriana) and a later‐successional ectomycorrhizal conifer (spruce, Picea engelmannii × glauca). The same plant species and later‐successional plants (spruce and/or redcedar, Thuja plicata, a mid‐ to late‐successional arbuscular mycorrhizal conifer) were grown as legacy‐phase seedlings in conditioned soils and unconditioned control soils. Legacy effects were evaluated based on seedling survival and biomass, and the abundance and diversity of root fungal symbionts and pathogens. We found negative intraspecific (same‐species) soil legacies for willow associated with pathogen accumulation, but neutral to positive intraspecific legacies in spruce associated with increased mycorrhizal fungal colonization and diversity. Our findings support research showing that soil legacy effects vary with plant nutrient acquisition strategy, with plants with low mycorrhizal dependence experiencing negative feedbacks and ectomycorrhizal plants experiencing positive feedbacks. Soil legacy effects of willow on next‐stage successional species (spruce and redcedar) were negative, potentially due to allelopathy, while ectomycorrhizal spruce had neutral to negative legacy effects on arbuscular mycorrhizal redcedar, likely due to the trees not associating with compatible mycorrhizae. Thus, positive biological legacies may be limited to scenarios where mycorrhizal‐dependent plants grow in soil containing legacies of compatible mycorrhizae. We found that soil legacies influenced plant performance in mine reclamation materials with and without forest soil additions, indicating that initial restoration actions may potentially exert long‐term effects on plant community composition, even in primary successional soils with low microbial activity.
Experimental application of a laser‐based manufacturing process to develop a free customizable, scalable thermoelectric generator demonstrated on a hot shaft
Authors: Abt Marvin , Kruppa Katharina , Wolf Mario , Feldhoff Armin , Overmeyer Ludger 
Published: November 2022

AbstractGeometry, design, and processing in addition to the thermoelectric material properties have a significant influence on the economic efficiency and performance of thermoelectric generators (TEGs). While conventional BULK TEGs are elaborate to manufacture and allow only limited variations in geometry, printed TEGs are often restricted in their application and processing temperature due to the use of organic materials. In this work, a proof‐of‐concept for fabricating modular, customizable, and temperature‐stable TEGs is demonstrated by applying an alternative laser process. For this purpose, low temperature cofired ceramics substrates were coated over a large area, freely structured and cut without masks by a laser and sintered to a solid structure in a single optimized thermal post‐processing. A scalable design with complex geometry and large cooling surface for application on a hot shaft was realized to prove feasibility. Investigations on sintering characteristics up to a peak temperature of 1173 K, thermoelectric material properties and temperature distribution were carried out for a Ca3Co4O9/Ag‐based prototype and evaluated using profilometer, XRD, and IR measurements. For a combined post‐processing, an optimal sintering profile could be determined at 1073 K peak temperature with a 20 min holding time. Temperature gradients of up to 100 K could be achieved along a thermocouple. A single TEG module consisting of 12 thermocouples achieved a maximum power of 0.224 μW and open‐circuit voltage of 134.41 mV at an average hot‐side temperature of 413.6 K and temperature difference of 106.7 K. Three of these modules combined into a common TEG with a total of 36 thermocouples reached a maximum power of 0.58 K and open‐circuit voltage of 319.28 mV with a lesser average hot‐side temperature of 387.8 K and temperature difference of 83.4 K.
Doxycycline use and adverse pregnancy or neonatal outcomes: A descriptive study using the United States Food and Drug Administration Adverse Event Reporting System database
Authors: Kaundinnyayana Sammodavardhana , Kamath Ashwin 
Published: November 2022

AbstractBackground and AimsDoxycycline is recommended for use in rickettsial diseases. The available evidence regarding its safety for rickettsial infection in pregnancy is limited. Our study aimed to describe the adverse events of doxycycline when used during pregnancy for any indication, in terms of adverse maternal and/or neonatal outcomes, using the United States Food and Drug Administration Adverse Event Reporting System (FAERS).MethodsWe used the OpenVigil software for extracting the safety reports from the United States submitted to the FAERS from 2004 to 2021. We manually reviewed reports of doxycycline use resulting in adverse pregnancy outcomes or congenital anomalies to describe the patient and safety event characteristics.ResultsFrom 2004 to 2021, 59 individual case safety reports containing preferred terms indicative of drug exposure during pregnancy or drug‐induced adverse fetal outcomes were identified in the FAERS database. Following deduplication and manual review, 20 relevant adverse event reports were obtained. Doxycycline was the suspect medication in 13/20 (65%) reports. The common adverse event terms reported were premature delivery/baby in 6 reports, spontaneous abortion in 6, intrauterine death in 2, and various congenital anomalies in the rest. Fifty percent of the safety reports contained other medications which could have potentially caused the outcome.ConclusionsThe number of reported events in the FAERS database of adverse pregnancy/neonatal outcomes following doxycycline use is small, similar to the numbers reported from large cohort or surveillance studies. Given the presence of concomitant medications that could have contributed to the outcome, there does not seem to be a strong signal of harm, although this needs to be confirmed by surveillance studies.