bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pulmonary function in school-age children following intravitreal injection of bevacizumab for retinopathy of prematurity
Authors: Huang Ching-Yen , Lai Shen-Hao , Tseng Hsiao-Jung , Yao Tsung-Chieh , Wu Wei-Chi 
Published: November 2022

AbstractThe effect of anti-vascular endothelial growth factor on neonatal lung development was inconclusive. To evaluate pulmonary function in school-age children who have received intravitreal bevacizumab (IVB) for retinopathy of prematurity (ROP), this study included 118 school-aged children who were grouped into three groups: full-term control children (group 1), preterm children who had not received IVB treatment (group 2) and preterm children with ROP who had received IVB treatment (group 3). Pulmonary function was measured by spirometry and impulse oscillometry. Pulmonary function was significantly better in group 1 than in groups 2 and 3 (all p < 0.05 in forced vital capacity (FVC), forced expiratory volume in 1 s (FEV1), forced expiratory flow between 25 and 75% of FVC (FEF25–75), and respiratory resistance at 5 Hz and difference between respiratory resistance at 5 and 20 Hz (R5-R20). There were no statistically significant differences between group 2 and group 3 in all pulmonary function parameters, including FVC, FEV1, ratio of FEV1 to FVC, FEF25-75, R5, R20, R5–R20, and respiratory reactance at 5 Hz. In conclusion, our study revealed that preterm infants receiving IVB for ROP had comparable pulmonary function at school age to their preterm peers who had not received IVB treatment.
Intellectually able adults with autism spectrum disorder show typical resting-state EEG activity
Authors: Li Qianliang , Weiland Ricarda F. , Konvalinka Ivana , Mansvelder Huibert D. , Andersen Tobias S. , Smit Dirk J. A. , Begeer Sander , Linkenkaer-Hansen Klaus 
Published: November 2022

AbstractThere is broad interest in discovering quantifiable physiological biomarkers for psychiatric disorders to aid diagnostic assessment. However, finding biomarkers for autism spectrum disorder (ASD) has proven particularly difficult, partly due to high heterogeneity. Here, we recorded five minutes eyes-closed rest electroencephalography (EEG) from 186 adults (51% with ASD and 49% without ASD) and investigated the potential of EEG biomarkers to classify ASD using three conventional machine learning models with two-layer cross-validation. Comprehensive characterization of spectral, temporal and spatial dimensions of source-modelled EEG resulted in 3443 biomarkers per recording. We found no significant group-mean or group-variance differences for any of the EEG features. Interestingly, we obtained validation accuracies above 80%; however, the best machine learning model merely distinguished ASD from the non-autistic comparison group with a mean balanced test accuracy of 56% on the entirely unseen test set. The large drop in model performance between validation and testing, stress the importance of rigorous model evaluation, and further highlights the high heterogeneity in ASD. Overall, the lack of significant differences and weak classification indicates that, at the group level, intellectually able adults with ASD show remarkably typical resting-state EEG.
Effect of Hele–Shaw cell gap on radial viscous fingering
Authors: Nand Sada , Sharma Vandita , Das Santanu Kumar , Padhee Srikant Sekhar , Mishra Manoranjan 
Published: November 2022

AbstractThe flow through a Hele–Shaw cell is an experimental prototype to study the flow through a porous medium as well as the flow in microfluidic devices. In context with porous medium flows, it is used to visualize and understand hydrodynamic instabilities like viscous fingering (VF). The gap between the plates of the cell is an important parameter affecting the flow dynamics. However, the effect of the gap on the Hele–Shaw cell flows has been minimally explored. We perform experiments to understand the effect of the gap on VF dynamics. It is observed that a minimum gap is required to observe rigorous fingering instability. The onset time of instability, as well as the width of the fingers, increases with an increment in the gap due to a decrease in the convection. The instability increases with an increase in Péclet number, but the effect of gap width on fingering patterns is evident with broader fingers observed for larger b. The results are validated by performing numerical simulations. It is further shown that the gap-averaged three-dimensional simulations using the Stokes law approach and the two-dimensional Darcy’s law result in a small gap Hele–Shaw cell.
Effect of dissolved humic acids and coated humic acids on tetracycline adsorption by K2CO3-activated magnetic biochar
Authors: Li Meifang , Wang Ping , Huang Chenxi , Liu Yunguo , Liu Shaobo , Zhang Ke , Cao Jingxiao , Tan Xiaofei , Liu Shaoheng 
Published: November 2022

AbstractHumic acids (HAs) widely exist in water environment, and has an important impact on the adsorption of pollutants. Herein, HAs (both dissolved and coated) was employed to assess the effect on the removal of the organic contaminant tetracycline (TC) by K2CO3 modified magnetic biochar (KMBC). Results showed that low concentration of dissolved HAs promoted TC removal, likely due to a bridging effect, while higher concentration of dissolved HAs inhibited TC adsorption because of the competition of adsorption sites on KMBC. By characterization analysis, coated HAs changed the surface and pore characteristics of KMBC, which suppressed the TC removal. In a sequential adsorption experiment involving dissolved HAs and TC, the addition of HAs at the end of the experiment led to the formation of HAs-TC ligands with free TC, which improved the adsorption capacity of TC. TC adsorption by KMBC in the presence of dissolved HAs and coated HAs showed a downward trend with increasing pH from 5.0 to 10.0. The TC adsorption process was favorable and endothermic, and could be better simulated by pseudo-second-order kinetics and Freundlich isotherm model. Hydrogen bonds and π–π interactions were hypothesized to be the underlying influencing mechanisms.
A systematic study of HIF1A cofactors in hypoxic cancer cells
Authors: Zhang Yuxiang , Wang Saidi , Hu Haiyan , Li Xiaoman 
Published: November 2022

AbstractHypoxia inducible factor 1 alpha (HIF1A) is a transcription factor (TF) that forms highly structural and functional protein–protein interactions with other TFs to promote gene expression in hypoxic cancer cells. However, despite the importance of these TF-TF interactions, we still lack a comprehensive view of many of the TF cofactors involved and how they cooperate. In this study, we systematically studied HIF1A cofactors in eight cancer cell lines using the computational motif mining tool, SIOMICS, and discovered 201 potential HIF1A cofactors, which included 21 of the 29 known HIF1A cofactors in public databases. These 201 cofactors were statistically and biologically significant, with 19 of the top 37 cofactors in our study directly validated in the literature. The remaining 18 were novel cofactors. These discovered cofactors can be essential to HIF1A’s regulatory functions and may lead to the discovery of new therapeutic targets in cancer treatment.
Urine volume as an estimator of residual renal clearance and urinary removal of solutes in patients undergoing peritoneal dialysis
Authors: Pinto Joyce , Debowska Malgorzata , Gomez Rafael , Waniewski Jacek , Lindholm Bengt 
Published: November 2022

AbstractIn non-anuric patients undergoing peritoneal dialysis (PD), residual kidney function (RKF) is a main contributor to fluid and solute removal and an independent predictor of survival. We investigated if urine volume could be used to estimate renal clearances and removal of urea, creatinine, and phosphorus in PD patients. The observational, cross-sectional study included 93 non-anuric prevalent PD patients undergoing continuous ambulatory PD (CAPD; n = 34) or automated PD (APD; n = 59). Concentrations of urea, creatinine and phosphorus in serum and in 24-h collections of urine volume were measured to calculate weekly residual renal clearance (L/week) and removed solute mass (g/week). Median [interquartile range], 24-h urine output was 560 [330–950] mL and measured GFR (the mean of creatinine and urea clearances) was 3.24 [1.47–5.67] mL/min. For urea, creatinine and phosphorus, residual renal clearance was 20.60 [11.49–35.79], 43.02 [19.13–75.48] and 17.50 [8.34–33.58] L/week, respectively, with no significant differences between CAPD and APD. Urine volume correlated positively with removed solute masses (rho = 0.82, 0.67 and 0.74) and with weekly residual renal clearances (rho = 0.77, 0.62 and 0.72 for urea, creatinine, and phosphorus, respectively, all p < 0.001). Residual renal clearances and urinary mass removal rates for urea, creatinine, and phosphorus correlate strongly with 24-h urine volume suggesting that urine volume could serve as an estimator of typical values of residual solute removal indices in PD patients.
Application of artificial intelligence to decode the relationships between smell, olfactory receptors and small molecules
Authors: Achebouche Rayane , Tromelin Anne , Audouze Karine , Taboureau Olivier 
Published: November 2022

AbstractDeciphering the relationship between molecules, olfactory receptors (ORs) and corresponding odors remains a challenging task. It requires a comprehensive identification of ORs responding to a given odorant. With the recent advances in artificial intelligence and the growing research in decoding the human olfactory perception from chemical features of odorant molecules, the applications of advanced machine learning have been revived. In this study, Convolutional Neural Network (CNN) and Graphical Convolutional Network (GCN) models have been developed on odorant molecules-odors and odorant molecules-olfactory receptors using a large set of 5955 molecules, 160 odors and 106 olfactory receptors. The performance of such models is promising with a Precision/Recall Area Under Curve of 0.66 for the odorant-odor and 0.91 for the odorant-olfactory receptor GCN models respectively. Furthermore, based on the correspondence of odors and ORs associated for a set of 389 compounds, an odor-olfactory receptor pairwise score was computed for each odor-OR combination allowing to suggest a combinatorial relationship between olfactory receptors and odors. Overall, this analysis demonstrate that artificial intelligence may pave the way in the identification of the smell perception and the full repertoire of receptors for a given odorant molecule.
High-speed videography of transparent media using illumination-based multiplexed schlieren
Authors: Ek Simon , Kornienko Vassily , Roth Adrian , Berrocal Edouard , Kristensson Elias 
Published: November 2022

AbstractSchlieren photography is widely used for visualizing phenomena within transparent media. The technique, which comes in a variety of configurations, is based on detecting or extracting the degree to which light is deflected whilst propagating through a sample. To date, high-speed schlieren videography can only be achieved using high-speed cameras, thus limiting the frame rate of such configurations to the capabilities of the camera. Here we demonstrate, for the first time, optically multiplexed schlieren videography, a concept that allows such hardware limitations to be bypassed, opening up for, in principle, an unlimited frame rate. By illuminating the sample with a rapid burst of uniquely spatially modulated light pulses, a temporally resolved sequence can be captured in a single photograph. The refractive index variations are thereafter measured by quantifying the local phase shift of the superimposed intensity modulations. The presented results demonstrate the ability to acquire a series of images of flame structures at frame rates up to 1 Mfps using a standard 50 fps sCMOS camera.
Javanese Homo erectus on the move in SE Asia circa 1.8 Ma
Authors: Husson Laurent , Salles Tristan , Lebatard Anne-Elisabeth , Zerathe Swann , Braucher Régis , Noerwidi Sofwan , Aribowo Sonny , Mallard Claire , Carcaillet Julien , Natawidjaja Danny H. , Bourlès Didier ,   ASTER team, Aumaitre Georges , Bourlès Didier , Keddadouche Karim 
Published: November 2022

AbstractThe migration ofHomo erectusin Southeast Asia during Early Pleistocene is cardinal to our comprehension of the evolution of the genusHomo. However, the limited consideration of the rapidly changing physical environment, together with controversial datings of hominin bearing sites, make it challenging to secure the robust timeline needed to unveil the behavior of early humans. Here, we reappraise the first appearance datum of JavaneseH. erectusby adding the most reliable age constraints based on cosmogenic nuclides$$^{10}$$10Be and$$^{26}$$26Al producedin situto a compilation of earlier estimates. We find thatH. erectusreached Java and dwelled at Sangiran, Java,ca.1.8 Ma. Using this age as a baseline, we develop a probabilistic approach to reconstruct their dispersal routes, coupling ecological movement simulations to landscape evolution models forced by reconstructed geodynamic and climatic histories. We demonstrate that the hospitableterra firmaconditions of Sundaland facilitated the prior dispersal of hominins to the edge of Java, where they conversely could not settle until the Javanese archipelago emerged from the sea and connected to Sundaland. The dispersal ofH. erectusacross Sundaland occurred over at least tens to hundreds kyr, a time scale over which changes in their physical environment, whether climatic or physiographic, may have become primary forcings on their behavior. Our comprehensive reconstruction method to unravel the peopling timeline of SE Asia provides a novel framework to evaluate the evolution of early humans.
Ocular morphologic traits in the American Cocker Spaniel may confer primary angle closure glaucoma susceptibility
Authors: Park Sangwan , Casanova M. Isabel , Bannasch Danika L. , Daley Nicole L. , Kim Soohyun , Kuchtey John , Gomes Filipe Espinheira , Leonard Brian C. , Good Kathryn L. , Martins Bianca da C. , Murphy Christopher J. , Thomasy Sara M. 
Published: November 2022

AbstractAcute primary angle closure glaucoma is a potentially blinding ophthalmic emergency requiring prompt treatment to lower the elevated intraocular pressure in humans and dogs. The PACG in most of canine breeds is epidemiologically similar to humans with older and female patients overrepresented with the condition. The American Cocker Spaniel (ACS) is among the most common breeds observed with PACG development in dogs. This study initially sought to identify genetic risk factors to explain the high prevalence of PACG in ACSs by using a case–control breed-matched genome-wide association study. However, the GWAS failed to identify candidate loci associated with PACG in this breed. This study then assessed intrinsic ocular morphologic traits that may relate to PACG susceptibility in this breed. Normal ACSs without glaucoma have a crowded anterior ocular segment and narrow iridocorneal angle and ciliary cleft, which is consistent with anatomical risk factors identified in humans. The ACSs showed unique features consisting of posterior bowing of iris and longer iridolenticular contact, which mirrors reverse pupillary block and pigment dispersion syndrome in humans. The ACS could hold potential to serve as an animal model of naturally occurring PACG in humans.
Reduced circulating FABP2 in patients with moderate to severe COVID-19 may indicate enterocyte functional change rather than cell death
Authors: Assante G. , Tourna A. , Carpani R. , Ferrari F. , Prati D. , Peyvandi F. , Blasi F. , Bandera A. , Le Guennec A. , Chokshi S. , Patel V. C. , Cox I. J. , Valenti L. , Youngson N. A. 
Published: November 2022

AbstractThe gut is of importance in the pathology of COVID-19 both as a route of infection, and gut dysfunction influencing the severity of disease. Systemic changes caused by SARS-CoV-2 gut infection include alterations in circulating levels of metabolites, nutrients and microbial products which alter immune and inflammatory responses. Circulating plasma markers for gut inflammation and damage such as zonulin, lipopolysaccharide and β-glycan increase in plasma along with severity of disease. However, Intestinal Fatty Acid Binding Protein / Fatty Acid Binding Protein 2 (I-FABP/FABP2), a widely used biomarker for gut cell death, has paradoxically been shown to be reduced in moderate to severe COVID-19. We also found this pattern in a pilot cohort of mild (n = 18) and moderately severe (n = 19) COVID-19 patients in Milan from March to June 2020. These patients were part of the first phase of COVID-19 in Europe and were therefore all unvaccinated. After exclusion of outliers, patients with more severe vs milder disease showed reduced FABP2 levels (median [IQR]) (124 [368] vs. 274 [558] pg/mL, P < 0.01). A reduction in NMR measured plasma relative lipid-CH3 levels approached significance (median [IQR]) (0.081 [0.011] vs. 0.073 [0.024], P = 0.06). Changes in circulating lipid levels are another feature commonly observed in severe COVID-19 and a weak positive correlation was observed in the more severe group between reduced FABP2 and reduced relative lipid-CH3 and lipid-CH2 levels. FABP2 is a key regulator of enterocyte lipid import, a process which is inhibited by gut SARS-CoV-2 infection. We propose that the reduced circulating FABP2 in moderate to severe COVID-19 is a marker of infected enterocyte functional change rather than gut damage, which could also contribute to the development of hypolipidemia in patients with more severe disease.
Generative adversarial network-created brain SPECTs of cerebral ischemia are indistinguishable to scans from real patients
Authors: Werner Rudolf A. , Higuchi Takahiro , Nose Naoko , Toriumi Fujio , Matsusaka Yohji , Kuji Ichiei , Kazuhiro Koshino 
Published: November 2022

AbstractDeep convolutional generative adversarial networks (GAN) allow for creating images from existing databases. We applied a modified light-weight GAN (FastGAN) algorithm to cerebral blood flow SPECTs and aimed to evaluate whether this technology can generate created images close to real patients. Investigating three anatomical levels (cerebellum, CER; basal ganglia, BG; cortex, COR), 551 normal (248 CER, 174 BG, 129 COR) and 387 pathological brain SPECTs using N-isopropyl p-I-123-iodoamphetamine (123I-IMP) were included. For the latter scans, cerebral ischemic disease comprised 291 uni- (66 CER, 116 BG, 109 COR) and 96 bilateral defect patterns (44 BG, 52 COR). Our model was trained using a three-compartment anatomical input (dataset ‘A’; including CER, BG, and COR), while for dataset ‘B’, only one anatomical region (COR) was included. Quantitative analyses provided mean counts (MC) and left/right (LR) hemisphere ratios, which were then compared to quantification from real images. For MC, ‘B’ was significantly different for normal and bilateral defect patterns (P < 0.0001, respectively), but not for unilateral ischemia (P = 0.77). Comparable results were recorded for LR, as normal and ischemia scans were significantly different relative to images acquired from real patients (P ≤ 0.01, respectively). Images provided by ‘A’, however, revealed comparable quantitative results when compared to real images, including normal (P = 0.8) and pathological scans (unilateral, P = 0.99; bilateral, P = 0.68) for MC. For LR, only uni- (P = 0.03), but not normal or bilateral defect scans (P ≥ 0.08) reached significance relative to images of real patients. With a minimum of only three anatomical compartments serving as stimuli, created cerebral SPECTs are indistinguishable to images from real patients. The applied FastGAN algorithm may allow to provide sufficient scan numbers in various clinical scenarios, e.g., for “data-hungry” deep learning technologies or in the context of orphan diseases.
An image registration method for voxel-wise analysis of whole-body oncological PET-CT
Authors: Jönsson Hanna , Ekström Simon , Strand Robin , Pedersen Mette A. , Molin Daniel , Ahlström Håkan , Kullberg Joel 
Published: November 2022

AbstractWhole-body positron emission tomography-computed tomography (PET-CT) imaging in oncology provides comprehensive information of each patient’s disease status. However, image interpretation of volumetric data is a complex and time-consuming task. In this work, an image registration method targeted towards computer-aided voxel-wise analysis of whole-body PET-CT data was developed. The method used both CT images and tissue segmentation masks in parallel to spatially align images step-by-step. To evaluate its performance, a set of baseline PET-CT images of 131 classical Hodgkin lymphoma (cHL) patients and longitudinal image series of 135 head and neck cancer (HNC) patients were registered between and within subjects according to the proposed method. Results showed that major organs and anatomical structures generally were registered correctly. Whole-body inverse consistency vector and intensity magnitude errors were on average less than 5 mm and 45 Hounsfield units respectively in both registration tasks. Image registration was feasible in time and the nearly automatic pipeline enabled efficient image processing. Metabolic tumor volumes of the cHL patients and registration-derived therapy-related tissue volume change of the HNC patients mapped to template spaces confirmed proof-of-concept. In conclusion, the method established a robust point-correspondence and enabled quantitative visualization of group-wise image features on voxel level.
A randomized pilot study of oncology massage to treat chemotherapy-induced peripheral neuropathy
Authors: Lopez Gabriel , Eng Cathy , Overman Michael , Ramirez David , Liu Wenli , Beinhorn Curtiss , Sumler Pamela , Prinsloo Sarah , Li Yisheng , Chen Minxing , Bruera Eduardo , Cohen Lorenzo 
Published: November 2022

AbstractThis pilot randomized controlled trial investigated massage therapy for symptomatic relief of chemotherapy-induced peripheral neuropathy (CIPN) to determine the ideal weekly frequency and number of weeks of providing massage. We evaluated the feasibility and initial efficacy of a Swedish massage protocol to treat lower extremity (LE) CIPN. Inclusion criteria: LE neuropathy attributed to oxaliplatin, paclitaxel, or docetaxel, with no other attributable causes; ≥ 6 months since last chemotherapy; self-reported neuropathy score ≥ 3, 0–10 scale; age ≥ 18. Participant randomization (2:2:1:1) to one of four groups: LE (2) or head/neck/shoulder (control; 1) massage 3 times (3X) a week for 4 weeks; LE (2) or control (1) massage 2X/week for 6 weeks. Completion rate and the Pain Quality Assessment Scale (PQAS) was measured at baseline and 10 weeks later. 71 patients participated: 77.5% women; 57.7% (breast cancer), and 42.3% (GI cancer); mean age 60.3 y/o (range: 40–77); average > 3 years since last chemotherapy. Massage was deemed feasible: mean completion rates (max = 12) were 8.9 (SD 4.2) for 3X/week and 9.8 (SD 4.0) for 2X/week with no statistically significant differences. There were no statistically significant treatment group interactions in PQAS scores at 10-weeks follow-up. There was a statistically significant treatment schedule main effect for PQAS subscales (p < 0.05) at 10 weeks, with lower CIPN symptoms for 3X/week groups versus 2X/week groups. Improvements considered clinically significant favored the LE 3X/week group. Completion rates met pre-defined feasibility criteria. We seemed to observe better outcomes (CIPN symptom reduction) with the more intensive (3X/week for 4 weeks) massage intervention with no differences in adherence, regardless of whether the massage was directly to the CIPN-affected area or not. However, there was some suggestion that the massage program targeting the CIPN-affected area directly provided 3X a week for 4 weeks resulted in the best outcomes.