bluuebunny/crossref_metadata_2025_split huggingface dataset:
Trends among patients with endometriosis over a 7-year period and the impact of the COVID-19 pandemic: experience from an academic high-level endometriosis centre in Germany
Authors: Keilmann Lucia , Beyer Susanne , Meister Sarah , Jegen Magdalena , Buschmann Christina , Schröder Lennard , Keckstein Simon , Jeschke Udo , Burges Alexander , Mahner Sven , Trillsch Fabian , Kost Bernd , Kolben Thomas 
Published: September 2022

Abstract
Purpose
Endometriosis is known to be an underestimated disease. Lately the awareness of the disease seems to have improved. Aim of this analysis is to provide an overview of the development of treatment of patients diagnosed with endometriosis. This includes a special scope on implications of the COVID-19 pandemic since in multiple settings postponed treatments resulting in negative impact on prognosis were reported.

Materials and methods
We analysed the development of numbers of patients treated for endometriosis in an academic centre within a 7-year period, 01/2015–12/2021, performing a systematic analysis of ICD-10-Codes from our computer system used in clinical routine.

Results
Treatment numbers increased over the past 7 years, i.e., 239 treated cases in 2015 vs. 679 in 2021.
Following restrictions for outpatient evaluation and surgical capacity at our centre, during COVID-19 pandemic the numbers of treated patients were reduced, especially in the first lockdown period (03/22/2020–05/05/2020 vs. same period in 2019: outpatient clinic (9 vs. 36; p < 0.001), patients surgically treated (27 vs. 52; p < 0,001)). The comparison of 2020 to 2019 showed a reduction in April 2020 of − 37% in outpatient department and up to − 90% for surgically treated patients. Comparing to 2019, we found a reduction of surgical interventions in 2020 by − 9% and an increase by 83% in 2021.

Conclusions
Raising numbers of patients treated for endometriosis point to a new awareness for the disease. After the decline during the lockdown period numbers raised again, leading to a delay, but not an omission of treatment. A certified endometriosis centre with established and well-organized structures is required to improve not only treatment results but also quality of life of those affected.
Pregnancy outcome and risk of recurrence after tissue-preserving loop electrosurgical excision procedure (LEEP)
Authors: Lieb Jule Alena , Mondal Anne , Lieb Lenard , Fehm Tanja Natascha , Hampl Monika 
Published: September 2022

Abstract
Background/purpose
This study aims to investigate whether women with cervical dysplasia after LEEP have an increased risk of pregnancy/childbirth complications or recurrence of dysplasia in an upcoming pregnancy.

Methods
Data from 240 women after LEEP were analysed retrospectively. The reference group consisted of 956 singleton births. Fisher’s and Wilcoxon rank tests were used to detect differences between groups. Using logistic regressions, we analysed the effect of surgery-specific aspects of LEEP on pregnancy/childbirth complications and the frequency of CIN recurrences.

Results
We found that tissue-preserving LEEP did not lead to premature birth or miscarriage and did not increase the likelihood of CIN recurrence.
We did not observe differences regarding preterm birth [< 37 (p < 0.28) < 34 (p < 0.31), < 32 weeks of gestation (p < 0.11)] or birth weight (< 2500 g (p < 0.54), < 2000 g (p < 0.77) between groups. However, women after LEEP exhibit a higher risk of premature rupture of membranes (PROM) at term (p < 0.009) and vaginal infections (p < 0.06). Neither volume nor depth of the removed tissue nor an additional endocervical resection seems to influence the likelihood of premature birth or early miscarriage. Performing an endocervical resection protects against CIN recurrence (OR 0.0881, p < 0.003).

Conclusions
After tissue-preserving LEEP, there is an increased risk of vaginal infections and PROM at term in consecutive pregnancy. LEEP does not affect prematurity or miscarriage. The removal of additional endocervical tissue appears to be a protective factor against recurrence of CIN.
Factors influencing the effect of external cephalic version: a retrospective nationwide cohort analysis
Authors: Londero Ambrogio P. , Xholli Anjeza , Massarotti Claudia , Fruscalzo Arrigo , Cagnacci Angelo 
Published: September 2022

Abstract
Objective
This study aims to assess the factors associated with the success and failure rate of the external cephalic version (ECV) in breech fetuses. Secondary outcomes were fetal presentation in labor and mode of delivery.

Methods
This cross-sectional study examined the live birth certificates from 2003 through 2020 from US states and territories that implemented the 2003 revision. A total of 149,671 singleton pregnancies with information about ECV success or failure were included. The outcome was ECV success/failure, while the exposures were possible factors associated with the outcome.

Results
The successful ECV procedures were 96,137 (64.23%). Among the successful ECV procedures, the prevalence of spontaneous vaginal delivery was 71.63%. Among the failed ECV procedures, 24.74% had a cephalic presentation at delivery, but 63.11% of these pregnancies were delivered by cesarean section. Nulliparity, female sex, low fetal weight centile, high pre-pregnancy BMI, high BMI at delivery, and high maternal weight gain during pregnancy were associated with an increased ECV failure (p < 0.001). African American, American Indian and Alaska Native race categories were significant protective factors against ECV failure (p < 0.001). Maternal age had a U-shape risk profile, whereas younger maternal age (< 25 years) and old maternal age (> 40 years) were significant protective factors against ECV failure (p < 0.001).

Conclusions
A high prevalence of successful ECV procedures and subsequent spontaneous vaginal delivery were found. The present results found nulliparity, maternal race, maternal age, female fetal sex, low fetal weight, and maternal anthropometric features correlated to ECV results. These findings can potentially improve the knowledge about the factors involved in ECV, allowing more informed counseling to the women undergoing this procedure.
Suicidality in psychiatric emergency department situations during the first and the second wave of COVID-19 pandemic
Authors: Kippe Yann David , Adam Maia , Finck Anna , Moran James Kenneth , Schouler-Ocak Meryam , Bermpohl Felix , Gutwinski Stefan , Goldschmidt Thomas 
Published: September 2022

AbstractPsychiatric patients are prone to mental health deterioration during the Covid-19 pandemic. Little is known about suicidality in psychiatric patients during the Covid-19 pandemic. This study is a retrospective chart review of psychiatric emergency department (pED) presentations with present or absent suicidality (5634 pED attendances, 4110 patients) in an academic pED in Berlin, Germany. Poisson regression analysis was performed on the effect of Covid-19 period on suicidality (suicidal ideation (SI), suicide plans (SP) or suicide attempt (SA)) during the first (3/2/2020–5/24/2020 “first-wave”) and second (9/15/2020–3/1/2021 “second-wave”) wave of the Covid-19 pandemic compared to the same periods one year earlier. During the first-wave the number of pED visits per person with SI, SP and SA was higher compared to one year earlier (SI RR = 1.614; p = 0.016; SP RR = 2.900; p = 0.004; SA RR = 9.862; p = 0.003). SI and SP were predicted by interaction between substance use disorder (SUD) and second-wave (SI RR = 1.305, p = 0.043; SP RR = 1.645, p = 0.018), SA was predicted by interaction between borderline personality disorder (BPD) and second-wave (RR = 7.128; p = 0.012). Suicidality increased during the first-wave of Covid-19 pandemic in our sample. In the second-wave this was found in patients with SUD and BPD. These patients may be at particular risk of suicidality during the Covid-19 pandemic.
Standardized procedure prevents perioperative and early complications in totally implantable venous-access ports—a complication analysis of more than 1000 TIVAP implantations
Authors: Thiel Karolin , Kalmbach Sarah , Maier Gerhard , Wichmann Dörte , Schenk Martin , Königsrainer Alfred , Thiel Christian 
Published: September 2022

Abstract

Purpose
Since their invention 40 years ago, totally implantable venous-access ports (TIVAPs) have become indispensable in cancer treatment. The aim of our study was to analyze complications under standardized operative and perioperative procedures and to identify risk factors for premature port catheter explantation.

Methods
A total of 1008 consecutive TIVAP implantations were studied for success rate, perioperative, early, and late complications. Surgical, clinical, and demographic factors were analyzed as potential risk factors for emergency port catheter explantation.

Results
Successful surgical TIVAP implantation was achieved in 1005/1008 (99.7%) cases. No intraoperative or perioperative complications occurred. A total of 32 early complications and 88 late complications were observed leading to explantation in 11/32 (34.4%) and 34/88 (38.6%) cases, respectively. The most common complications were infections in 4.7% followed by thrombosis in 3.6%. Parameters that correlated with unplanned TIVAP explantation were gender (port in situ: female 95% vs. male 91%, p = 0.01), underlying disease (breast cancer 97% vs. gastrointestinal 89%, p = 0.004), indication (chemotherapy 95% vs. combination of chemotherapy and parenteral nutrition 64%, p < 0.0001), and type of complication (infection 13.4% vs. TIVAP-related complication 54% and thrombosis 95%, p < 0.0001).

Conclusion
Standardized operative and perioperative TIVAP implantation procedures provide excellent results and low explantation rate.
High RIG-I and EFTUD2 expression predicts poor survival in endometrial cancer
Authors: Beyer Susanne , Müller Lena , Mitter Sophie , Keilmann Lucia , Meister Sarah , Buschmann Christina , Kraus Fabian , Topalov Nicole E. , Czogalla Bastian , Trillsch Fabian , Burges Alexander , Mahner Sven , Schmoeckel Elisa , Löb Sanja , Corradini Stefanie , Kessler Mirjana , Jeschke Udo , Kolben Thomas 
Published: September 2022

Abstract
Purpose
Endometrial cancer is the most common gynecological malignancy. The helicase RIG-I, a part of the innate immune system, and EFTUD2, a splicing factor which can upregulate RIG-I expression, are shown to influence tumor growth and disease progression in several malignancies. For endometrial cancer, an immunogenic cancer, data about RIG-I and EFTUD2 are still missing. The aim of this study was to examine the expression of RIG-I and EFTUD2 in endometrial cancer.

Methods
225 specimen of endometrial cancer were immunohistochemically stained for RIG-I and EFTUD2. The results were correlated to clinicopathological data, overall survival (OS) and progression-free survival (PFS).

Results
High RIG-I expression correlated with advanced tumor stages (FIGO: p = 0.027; pT: p = 0.010) and worse survival rates (OS: p = 0.009; PFS: p = 0.022). High EFTUD2 expression correlated to worse survival rates (OS: p = 0.026; PFS: p < 0.001) and was determined to be an independent marker for progression-free survival.

Conclusion
Our data suggest that the expression of RIG-I and EFTUD2 correlates with survival data, which makes both a possible therapeutic target in the future.
Characterization of Clinostomum (Digenea: Clinostomidae) spp. in India
Authors: Choudhary Kirti , Ray Shailendra , Shamsi Shokoofeh , Agrawal Nirupama 
Published: September 2022

Abstract
Platyhelminths belonging to the family Clinostomidae (Digenea) have a worldwide distribution and are known to infect piscivorous birds through their intermediate hosts, usually fish species. In the present study, clinostome metacercariae were collected from fish hosts, including Channa punctata (Bloch 1793) (n = 25) and Trichogaster fasciata Bloch and Schneider 1801 (n = 25), from a freshwater system in India. The experimental infection of cattle egrets, Ardea (Bubulcus) ibis Linnaeus 1758, with some of the live metacercariae found in the present study was successful. Live adult parasites were obtained from the buccal cavity of the birds. Both metacercaria and adult specimens were subjected to molecular studies to obtain the sequences of 28S, ITS1, and ITS2 (nuclear rDNA) regions. The parasites were found to belong to three species, Clinostomum giganticum Agarwal 1959; C. piscidium Southwell and Prashad 1918; and Euclinostomum heterostomum (Rudolphi 1809). Phylogenetic analyses of the sequences obtained from the adults and metacercariae established a link between the metacercariae in the fish hosts and adults in the avian host, which is essential to elucidate their partial life cycle and specify morphological characteristics in the metacercarial stage.
Relationships of frequencies of extreme low temperatures with grain yield of some Australian commercial chickpea cultivars
Authors: Chauhan Yashvir S. , Allard Sam , Krosch Steve , Ryan Merrill , Rachaputi R. C. N. 
Published: September 2022

Abstract
In this study, we examined the relationships between extremes of low temperatures and chickpea yield in 12 field experiments conducted at six sites in the subtropical environment of southeast Queensland (SEQ) from 2014 to 2019. Three commercial chickpea cultivars, PBA-Boundary, PBA-HatTrick and PBA-Seamer, were grown in all the experiments. Cultivars PBA-Pistol, PBA-Monarch and Kyabra were also included in three of these experiments conducted in 2015. In these experiments, the crop experienced a total of 8 to 41 frosts (minimum temperature <  = 0 °C), 2 to 41 pre-flowering frosts, 2 to 19 frosts during the critical period, 0 to 13 frosts and 2 to 71 low-temperature days (< = 15 °C) after flowering. The mean yield, which varied from 1 to 3 t/ha, was negatively related to post-flowering frosts (r =  − 0.74, p < 0.01) and low-temperature days (r =  − 0.76, p < 0.01), and positively related to pre-flowering frosts (r = 0.67, p < 0.05). Each post-flowering frost was associated with a 5% decrease and a low-temperature day with a 1% decrease in yield. The cultivar × site interaction was significant only in the three experiments with six commercial cultivars. This interaction was most likely due to an increase in the sensitivity range with additional cultivars, as indicated by frost damage scores and their relationships with yield. The results imply that extreme low-temperature events after flowering could negatively impact chickpea yield in SEQ and similar subtropical environments. Overcoming these effects through management and breeding should increase and stabilise chickpea yield.
Quo vadis, gemeinsames Notfallleitsystem?
Authors: Breuer Florian , Brettschneider Paul , Poloczek Stefan , Pommerenke Christopher , Wolff Justus , Dahmen Janosch 
Published: September 2022

ZusammenfassungDie Zahl von Hilfeersuchen an die Notrufnummer 112 sowie die Einsatzzahlen im Rettungsdienst nehmen seit vielen Jahren insbesondere in urbanen Regionen Deutschlands massiv zu. Die Leitstelle kann hier als Steuerungsinstrument mit Lotsenfunktion genutzt werden, um neue Wege bei der Notrufbearbeitung sowie der Disposition von Einsatzmitteln zu gehen und das Anrufaufkommen hiermit möglichst effizient zu leiten. Es werden die standardisierte Notrufabfrage sowie weitere wichtige Strukturen und Pfade anhand der Leitstelle der Berliner Feuerwehr mit Fokus auf medizinische Notrufe, auch vor dem Hintergrund der COVID-19-Pandemie, dargelegt und näher erläutert. Strukturierte und standardisierte Notrufabfrage sind voneinander abzugrenzen, wobei die standardisierte Notrufabfrage verbindlich und auf Grundlage internationaler Standards mit hoher Reliabilität erfolgt. Ein strukturiertes Qualitätsmanagement sorgt für eine regeltreue Anwendung des Protokolls. Durch eine verbesserte Zusammenarbeit und eine elektronische Schnittstelle zur Leitstelle der kassenärztlichen Vereinigung können niedrigprioritäre Einsätze dorthin weitergeleitet werden. Interprofessionelle Teams im Rettungsdienst können zielgerichtet die Versorgung bestimmter Patientengruppen verbessern sowie zur Vermeidung von Transporten beitragen. Die standardisierte, softwaregestützte Notrufabfrage entspricht dem aktuellen Stand der Wissenschaft, wobei eine flächendeckende Einführung sinnvoll erscheint. Des Weiteren empfehlen sich eine intensive Zusammenarbeit von Leitstellen der Notfallrettung und der kassenärztlichen Vereinigung, die bedarfsadaptierte Einführung spezialisierter Einsatzmittel sowie die applikationsunterstützte Alarmierung von Ersthelfern.
Environmental Impacts of Large-Scale Spirulina (Arthrospira platensis) Production in Hellisheidi Geothermal Park Iceland: Life Cycle Assessment
Authors: Tzachor Asaf , Smidt-Jensen Asger , Ramel Alfons , Geirsdóttir Margrét 
Published: September 2022

AbstractSpirulina algae (Spirulina platensis) cultivated in geothermally powered photobioreactors is here proposed as a potentially resource efficient, zero-carbon, and nutritious alternative to conventional beef meat. Employing a standard life cycle assessment, environmental impacts of large-scale Spirulina production in this facility are calculated. The production facility is sited in Orka náttúrunnar (ON Power) Geothermal Park, Iceland, and benefits from resource streams accessible through Hellisheiði (Hellisheidi) power station, including renewable electricity for illumination and power usage, hot and cold water streams for thermal management, freshwater for cultivation, and CO2 for biofixation. During cultivation, GHG-intensive ammonia-based fertilizers are replaced with macronutrients sourced from natural open mines. LCA results show that production of 1 kg of wet edible biomass in this facility requires 0.0378 m2 non-arable land, 8.36 m3 fresh water and is carbon neutral with − 0.008 CO2-eq GHG emissions (net zero). Compared with conventionally produced meat from beef cattle, Spirulina algae cultured in the ON Power Geothermal Park, referred to in this study as GeoSpirulina, requires less than 1% land and water and emits less than 1% GHGs. Considering food and nutritional security concerns, cultivation in a controlled environment agriculture system assures consistent nutritional profile year-round. Moreover, GeoSpirulina biomass assessed in this study contains all essential amino acids as well as essential vitamins and minerals. While keeping a balanced nutrition, for every kg beef meat replaced with one kg GeoSpirulina, the average consumer can save ~ 100 kg CO2-eq GHGs. It is concluded that environmental impacts of GeoSpirulina production in the Hellisheidi facility are considerably lower than those of conventionally produced ruminants.
Graphical abstract
Vaginom- und „Endometriom“-Diagnostik bei Kinderwunsch
Authors: Heizmann Wolfgang R. , Keck Christoph 
Published: September 2022

ZusammenfassungDie molekulare Diagnostik der Vaginal- und Endometriumflora ermöglicht neue Einblicke in die physiologische Besiedlung des weiblichen Genitaltrakts. Wesentlich ist hierbei eine Dominanz von bestimmten Laktobazillenarten bei gleichzeitig geringer Artenvielfalt. Die Bildung von D‑Laktat ist eine entscheidende Voraussetzung für die Abwehr von sexuell übertragbaren Erkrankungen, den Erfolg einer In-vitro-Fertilisation sowie einen ungestörten Schwangerschaftsverlauf. Eine Störung der Flora durch pathogene Bakterienarten mit der Folge des Auftretens einer bakteriellen Vaginose oder einer chronischen Endometritis kann zu Implantationsversagen, Aborten und Frühgeburtsbestrebungen führen. Bei wiederholtem Implantationsversagen ermöglicht eine Mikrobiomdiagnostik – im Gegensatz zur klassischen Kultur, den Amsel-Kriterien oder dem Nugent-Score – einen sehr viel detaillierteren Einblick in die Pathophysiologie, da sich entscheidende Bakterienarten nur schwer oder gar nicht anzüchten lassen. Dies erlaubt eine sehr viel bessere Planung der Therapie zur Wiederherstellung physiologischer Verhältnisse.
Study of the optimum fluoroscopic angle for the implant fixation test of a leadless cardiac pacemaker
Authors: Zhang Jiang-Hua , Chen Cheng , Xing Qiang , Zhou Xian-Hui , Li Yao-Dong , Zhang Ling , Lu Yan-Mei , Tu-Erhong Zu Kela , Yang Xu , Liu Xing-Bin , Tang Bao-Peng 
Published: September 2022

AbstractThe Micra TPS™ (Medtronic) is the first leadless pacemaker listed in China. The best fluoroscopic angle for the intraoperative fixation test is selected according to different implantation sites to reduce the fluoroscopy duration and radiation dose, and the test is based on the early safety and effectiveness of the device after implantation. A total of 110 patients who underwent Micra TPS™ implantation were selected. Eighty patients were in group A, and 30 patients were in group B. Under the guidance of the conclusions from group A, the fluoroscopy duration, radiation dose and number of fluoroscopic positions of the best fluoroscopic angle of the fixation test according to different positions of the implanted interventricular septum were compared. In 85.0% of the group A implants, these angles were based on the right interior oblique (RAO) angle, with 48.5% cranial (CRA) and 29.4% caudal (CAU) angles. The angle of the tilting head side of the RAO angle was prioritized in group B, and referring to the average angle data, the average fluoroscopy duration for finding the best angle of fixation test was 1.7 ± 0.6 vs. 3.2 ± 1.8 min (P < 0.001), the average radiation dose was 270.4 ± 56.3 vs. 338.1 ± 112.9 mGy (P = 0.002), and the average number of fluoroscopic positions was 2.2 ± 0.6 vs. 4.2 ± 2.1 (P < 0.001), which was significantly less than that in group A. This study found that there was regularity in the fluoroscopic angle for the fixation test during Micra TPS™ operation.Level of Evidence Level 3, local nonrandom sample.
Derivatives of diphenylamine and benzothiadiazole in optoelectronic applications: a review
Authors: Hancharova Marharyta , Mazur Karolina , Halicka Kinga , Zając Dorota 
Published: September 2022

AbstractLight-emitting conjugated organic compounds have found special interest among researchers. Because of their adjustable optoelectronic properties they can be applied in e.g. field-effect transistors, sensors, light-emitting diodes or photovoltaic cells. In order to develop high-performance systems, it is important to understand the relationship between the structure and the photophysical properties of the material used. One of the employed strategies is to decrease the band gap of conjugated compounds, often achieved through a “donor–acceptor” approach. One of the popular groups applied as an electron-accepting unit are benzothiadiazoles, while diphenylamine exhibits good electron-donating ability. The functional groups can affect the energy levels of materials, influencing the color of the light emitted. This work presents a review of research focused on the structure-properties relationship of diphenylamine and benzothiadiazole derivatives with optoelectronic applications.
Pure Quotation in Linguistic Context
Authors: Rabern Brian 
Published: September 2022

AbstractA common framing has it that any adequate treatment of quotation has to abandon one of the following three principles: (i) The quoted expression is a syntactic constituent of the quote phrase; (ii) If two expressions are derived by applying the same syntactic rule to a sequence of synonymous expressions, then they are synonymous; (iii) The language contains synonymous but distinct expressions. In the following, a formal syntax and semantics will be provided for a quotational language which adheres to all three principles. The point here is not merely to provide a “possibility proof”, but to reveal the hard constraints on the theory of quotation, and to highlight certain assumptions at the syntax/semantics/post-semantics interfaces.