bluuebunny/crossref_metadata_2025_split huggingface dataset:
Predictive Parameters in Patients Undergoing Percutaneous Hepatic Perfusion with Melphalan for Unresectable Liver Metastases from Uveal Melanoma: A Retrospective Pooled Analysis
Authors: Tong T. M. L. , Samim M. , Kapiteijn E. , Meijer T. S. , Speetjens F. M. , Brüning R. , Schroeder T. H. , El-Sanosy S. , Maschke H. , Wacker F. K. , Vogel A. , Dewald C. L. A. , Goeman J. J. , Burgmans M. C. 
Published: August 2022

Abstract
Purpose
The aim of this study was to identify positive predictors for survival in uveal melanoma (UM) patients treated with percutaneous hepatic perfusion with melphalan (M-PHP), by retrospectively pooling data from three centers.

Materials and Methods
Retrospective analysis including patients ($$\ge$$
≥
18 years) treated with M-PHP between February 2014 and December 2019 for unresectable liver-dominant or liver-only metastases from UM. Predictors for OS were assessed using uni- and multivariate analyses. Other study outcome measures were response rate, progression-free survival (PFS), liver progression-free survival (LPFS), overall survival (OS) and complications according to CTCAEv5.0.

Results
In total, 101 patients (47.5% males; median age 59.0 years) completed a minimum of one M-PHP. At a median follow-up time of 15.0 months, complete response (CR), partial response (PR), stable disease (SD) and progressive disease were seen in five (5.0%), 55 (54.5%), 30 (29.7%) and 11 (10.9%) patients, respectively, leading to a 89.1% disease control rate. Median PFS, LPFS and OS were 9.0, 11.0 and 20.0 months, respectively. Survival analyses stratified for radiological response demonstrated significant improved survival in patients with CR or PR and SD category. Treatment of the primary tumor with radiotherapy, ≥ 2 M-PHP and lactate dehydrogenase (LDH) < 248 U/L were correlated with improved OS. Thirty-day mortality was 1.1% (n = 2). Most common complication was hematological toxicity (self-limiting in most cases).

Conclusion
M-PHP is safe and effective in patients with UM liver metastases. Achieving CR, PR or SD is associated with improved survival. Primary tumor treatment with radiotherapy, normal baseline LDH and > 1 M-PHP cycles are associated with improved OS.
Efficacy and safety of a colostrum- and Aloe vera-based oral care protocol to prevent and treat severe oral mucositis in patients undergoing hematopoietic stem cell transplantation: a single-arm phase II study
Authors: Guberti Monica , Botti Stefano , Caffarri Cristiana , Cavuto Silvio , Savoldi Luisa , Fusco Andrea , Merli Francesco , Piredda Michela , De Marinis Maria Grazia 
Published: August 2022

AbstractOral mucositis is one of the worst effects of the conditioning regimens given to patients undergoing hematopoietic stem cell transplantation. It is characterized by dry mouth, erythema, mucosal soreness, ulcers, and pain, and it may impact patient outcomes. Bovine colostrum and Aloe vera contain a wide variety of biologically active compounds that promote mucosal healing. A non-randomized phase II study was designed to assess the safety and efficacy of a combined bovine colostrum and Aloe vera oral care protocol to prevent and to treat severe oral mucositis in transplant patients. Two commercially available products were given to patients in addition to the standard protocol: Remargin Colostrum OS® mouthwash and Remargin Colostrum Gastro-Gel® taken orally. Forty-six (78.0%) patients experienced oral mucositis, 40 (67.8%) developed mild–moderate forms, and 6 (10.2%) severe ones. Comparing the study group’s outcomes with those of a homogeneous historical control group, severe oral mucositis decreased significantly (10.2% vs. 28.4%; P < 0.01), as did its duration (0.5 ± 1.9 vs. 1.5 ± 3.0 days; P < 0.01). Febrile neutropenia episodes (69.5% vs. 95.1%; P < 0.01) and duration (4.0 ± 4.7 vs. 6.2 ± 4.5 days; P < 0.01) also decreased. These findings show that the experimental protocol seems effective in preventing severe forms of oral mucositis. However, a randomized controlled trial is necessary to confirm this.
Injection moulding of micropillar arrays: a comparison of poly(methyl methacrylate) and cyclic olefin copolymer
Authors: Guan Bin , Pai Jing-Hong , Cherrill Mark , Michalatos Billy , Priest Craig 
Published: August 2022

AbstractInjection moulding of micropillar arrays offers a fast and inexpensive method for manufacturing sensors, optics, lab-on-a-chip devices, and medical devices. Material choice is important for both the function of the device and manufacturing optimisation. Here, a comparative study of poly(methyl methacrylate) (PMMA) and cyclic olefin copolymer (COC) injection moulding of micropillar arrays is presented. These two polymers are chosen for their convenient physical, chemical, and optical properties, which are favoured for microfluidic devices. COC is shown to replicate the mould’s nano/microstructures more precisely than PMMA. COC successfully forms a micropillar array (250 mm diameter; 496 mm high) and closely replicates surfaces with nano-scale roughness (30–120 nm). In the same moulds, PMMA forms lens arrays (not true pillars) and smoother surfaces due to the incomplete filling for all parameters studied. Thus, COC offers finer structural detail for devices that require micro and nano-structured features, and may be more suited to injection moulding microfluidic devices.
Challenges for health systems seeking to embrace virtual health care for population health
Authors: Kanavos Panos , Vogelsang Michelle , Haig Madeleine , Kolovou Vasiliki 
Published: August 2022

AbstractA gradual move to proactive illness prevention requires a strategic shift towards population health management by health care systems. Such a shift becomes necessary to improve outcomes, reduce inequalities and manage costs better, as life expectancy increases and chronic illness becomes more prevalent. Health system digitisation and greater focus on virtual health care (VHC) can contribute to active population health management. For that to happen, health systems need to address and overcome several challenges currently preventing the rapid introduction and scale up of VHC for population health; these include implementing changes in care models and focus on digitally enabled population health approaches; addressing culture and mindset barriers; resolving regulatory bottlenecks; overcoming technical limitations, inter-operability and data security issues; and, finally, aligning stakeholder incentives and expectations.
Analysis of uveal melanomas and paired constitutional DNA for exclusion of a BAP1-tumor predisposition syndrome
Authors: Abbassi Yasaman Arjmand , Le Guin Claudia , Bornfeld Norbert , Bechrakis Nikolaos E. , Zeschnigk Michael , Lohmann Dietmar R. 
Published: August 2022

AbstractUveal melanoma (UM) is a rare tumor originating from melanocytic cells in the eye. Familial aggregation of UM is rare and can occur as part of the tumor predisposition syndrome BAP1-TPDS. However, family history alone will only identify a subset of patients with BAP1-TPDS. In the present study, we used sequential testing of tumor and blood DNA from UM patients for differential diagnosis of BAP1-TPDS. The study group was an unselected prospective cohort of patients from whom UM tissue was available. First, chromosome 3 status in tumor DNA was determined in all 140 patients who consented to participate. As tumors with disomy 3 rarely show BAP1 alterations, sequence analysis of this gene was performed in the 72 tumors with monosomy 3 (M3) or partial M3 only. We identified oncogenic BAP1 alterations in 52 of these tumors (72%). Targeted sequencing of DNA from matched peripheral blood showed pathogenic variants in two patients (3.8%) thus proving BAP1-TPDS. Only one of these two patients also had a medical history suggestive of this syndrome. Conversely, in three patients known to have had additional tumors before diagnosis of UM, constitutional heterozygosity for a BAP1 mutation was excluded. Altogether, in 50 patients we could exclude BAP1-TPDS with high diagnostic certainty. The results of our study support that genetic testing for BAP1-TPDS should be offered to all patients with UM. Moreover, as genetic information from the tumor can help exclude heritable risk, the strategy for analysis should include efforts to obtain tumor samples for testing.
Predicting negative Effects of Climate Change on Taiwan’s endemic Bumblebee Bombus formosellus
Authors: Lu Ming-Lun , Huang Jing-Yi 
Published: August 2022

AbstractIntroduction: Climate change is threatening biodiversity hotspots. Notably, alpine bumblebees, which are mostly associated with a cold ecological niche, face a higher risk of extinction. Bombus formosellus is one of the alpine bumblebees endemic to Taiwan.Aims/Methods: In this study, we use ensemble ecological niche modeling for the first time to predict spatial and temporal dynamics for habitats suitable to B. formosellus under current and future climate scenarios (representative concentration pathway, RCP 2.6, 4.5, and 8.5 in the 2070s).Results: This model identified that the cool temperature with low variation, a specific range of precipitation and presence of coniferous forest and grasslands were the key factors affecting the distribution of B. formosellus. Using modeling to predict suitable habitats under various scenarios, we discovered that, compared with the current climatic conditions, the predicted suitable habitat area in the future decreased regardless of which climate change scenario was applied. In particular, RCP 8.5 appeared to be the most significant, with an area loss of nearly 87%, and fragmentation of the landscape with poor connection.Discussion: In summary, our analyses indicate that cool environments are suitable for B. formosellus. However, Taiwan’s warming is more significant in the high mountains than in the plains. The climate change trajectory may become increasingly unfavorable to B. formosellus. Consequently, this species may face the risk of extinction in the future.Implications for insect conservation: We predict that many suitable habitats of B. formosellus will disappear or become fragmented in the future. Therefore, the remaining patches have become important refuges, and protection measures in these areas should be strengthened.
Ischemic Tolerance Induced by Glial Cells
Authors: Koizumi Schuichi , Hirayama Yuri 
Published: August 2022

AbstractIschemic tolerance is a phenomenon in which resistance to subsequent invasive ischemia is acquired by a preceding noninvasive ischemic application, and is observed in many organs, including the brain, the organ most vulnerable to ischemic insult. To date, much research has been conducted on cerebral ischemic tolerance as a cell-autonomous action of neurons. In this article, we review the essential roles of microglia and astrocytes in the acquisition of ischemic tolerance through neuron-non-autonomous mechanisms, where the two types of glial cells function in a concerted manner to induce ischemic tolerance.
Policy feedback and institutional context in energy transitions
Authors: Lockwood Matthew 
Published: August 2022

AbstractInterest in policy feedback processes in energy transitions has grown rapidly in recent years. However, while it has provided interesting accounts of the mechanisms of stability or change, the policy feedback framework begs the question of why policy feedback dynamics vary so widely across cases. Existing accounts have tended to focus on the influence of ideas on policy design and on the role of interest groups. By contrast, the role of background institutional context in shaping policy feedback processes has been understudied. In this article, I develop a framework for identifying relevant types of institution that potentially shape policy feedback across different analytical stages of the feedback cycle. This approach is illustrated through the example of support policies for solar PV, where it is argued that a relatively small set of political, political economy and social institutions are likely to be important. The argument is then applied through a comparison of the evolution of solar PV policy in the UK and Germany, and the role of institutional context in explaining divergent policy pathways.
Are the folk utilitarian about animals?
Authors: Kahane Guy , Caviola Lucius 
Published: August 2022

AbstractRobert Nozick famously raised the possibility that there is a sense in which both deontology and utilitarianism are true: deontology applies to humans while utilitarianism applies to animals. In recent years, there has been increasing interest in such a hybrid views of ethics. Discussions of this Nozickian Hybrid View, and similar approaches to animal ethics, often assume that such an approach reflects the commonsense view, and best captures common moral intuitions. However, recent psychological work challenges this empirical assumption. We review evidence suggesting that the folk is deontological all the way down—it is just that the moral side constraints that protect animals from harm are much weaker than those that protect humans. In fact, it appears that people even attribute some deontological protections, albeit extremely weak ones, to inanimate objects. We call this view Multi-level Weighted Deontology. While such empirical findings cannot show that the Nozickian Hybrid View is false, or that it is unjustified, they do remove its core intuitive support. That support belongs to Multi-level Weighted Deontology, a view that is also in line with the view that Nozick himself seemed to favour. To complicate things, however, we also review evidence that our intuitions about the moral status of humans are, at least in significant part, shaped by factors relating to mere species membership that seem morally irrelevant. We end by considering the potential debunking upshot of such findings about the sources of common moral intuitions about the moral status of animals.
Effect of resistance training on bioelectrical phase angle in older adults: a systematic review with Meta-analysis of randomized controlled trials
Authors: Campa Francesco , Colognesi Lucas Antonio , Moro Tatiana , Paoli Antonio , Casolo Andrea , Santos Leandro , Correia Rafael Ribeiro , Lemes Ítalo Ribeiro , Milanez Vinícius Flávio , Christofaro Diego Destro , Cyrino Edilson Serpeloni , Gobbo Luís Alberto 
Published: August 2022

AbstractResistance training has been proposed as a valid practice to counteract the aging effect on body mass and its components, which can be easily evaluated though the bioelectrical impedance analysis. This study aimed to achieve a systematic review with meta-analysis on the impact of resistance training on bioelectrical proprieties in older adults.A literature review was done in four electronic databases up to 1 January 2022. The inclusion criteria were: (i) participants aged ≥ 60 years; (ii) resistance training lasted ≥ 8 weeks; (iii) measurement of raw bioelectrical parameters in randomized controlled study designs.The outcomes of the trial had to be bioelectrical phase angle (PhA), resistance (R), and reactance (Xc). The methodological quality was assessed using the Rosendal scale.Overall, seven studies with a total of 344 participants were eligible for the analysis. The quality assessment yielded a score of 71.3%. Bioelectrical PhA (0.52 degree [95%CI 0.32, 0.71], p < 0.001) and Xc (3.58 ohms [95%CI 1.97, 5.19], p < 0.001) increased, whereas R decreased (-28.50 ohms [95%CI -41.39, -15.60], p < 0.001) after the resistance training programs.In this meta-analysis, resistance training promoted increases of PhA, which result from an increase in Xc concomitant with a reduction in R. According to the bioimpedance vector analysis, resistance-trained people experienced a beneficial leftward vector displacement, whilst inactivity induced a rightward vector displacement within the R-Xc graph. In future, more sophisticated and rigorous studies that address specific criteria, methods and targeted designs are required to identify which equipment and protocols allow for an optimization of the resistance training effects.Registration code in PROSPERO: CRD42020168057.
Power and entrepreneurship
Authors: Audretsch David B. , Fiedler Antje 
Published: August 2022

AbstractEntrepreneurship research has benefited from embracing three economic sociology lenses—networks, cognition, and institutions—but has treated power mainly implicitly. This paper pioneers how the concept of power can advance research into entrepreneurship. We illustrate how state actors, legacy firms, and entrepreneurs variously exert coercive, persuasive, and authoritative forms of power over entrepreneurial opportunities or exercise power to pursue them as free actors. We explicitly link context and opportunity-development processes through a power lens and show how power’s interaction-focused and episodic nature that can transcend geographical and institutional boundaries might enrich entrepreneurship research.
The Response of Gas Hydrates to Tectonic Uplift
Authors: Oluwunmi Paul , Pecher Ingo , Archer Rosalind , Reagan Matthew , Moridis George 
Published: August 2022

AbstractPressure reduction following uplift may lead to dissociation of gas hydrates. The dynamics of hydrate dissociation in such settings, however, are poorly understood. We used TOUGH+HYDRATE to investigate the response of gas hydrates to an uplift of 0.009 myr$$^{-1}$$

-
1

over the last 8 kyrs, the approximate end of the postglacial sea-level rise. Geological parameters for the simulations are based on hydrate deposits from the Nankai Trough subduction zone. Our results suggest stabilisation from endothermic cooling, elevated pore pressure, and pore water freshening significantly slows hydrate dissociation such that the hydrate remains in place at its pre-uplift level. A shallower hydrate layer forms from upward-migrating gas when assuming moderate to high permeability (10$$^{-15}$$

-
15

and 10$$^{-13}$$

-
13

m$$^{2}$$

2

), while gas remains trapped for low permeability (10$$^{-17}$$

-
17

m$$^{2}$$

2

). In the latter case, we predict elevated pore pressure with potential implications for seafloor stability. Our findings suggest that following uplift, hydrates may exist outside the predicted regional gas hydrate stability field for thousands of years.
Pre-symptomatic radiological changes in frontotemporal dementia: propagation characteristics, predictive value and implications for clinical trials
Authors: McKenna Mary Clare , Lope Jasmin , Tan Ee Ling , Bede Peter 
Published: August 2022

Abstract
Computational imaging and quantitative biomarkers offer invaluable insights in the pre-symptomatic phase of neurodegenerative conditions several years before clinical manifestation. In recent years, there has been a focused effort to characterize pre-symptomatic cerebral changes in familial frontotemporal dementias using computational imaging. Accordingly, a systematic literature review was conducted of original articles investigating pre-symptomatic imaging changes in frontotemporal dementia focusing on study design, imaging modalities, data interpretation, control cohorts and key findings. The review is limited to the most common genotypes: chromosome 9 open reading frame 72 (C9orf72), progranulin (GRN), or microtubule-associated protein tau (MAPT) genotypes. Sixty-eight studies were identified with a median sample size of 15 (3–141) per genotype. Only a minority of studies were longitudinal (28%; 19/68) with a median follow-up of 2 (1–8) years. MRI (97%; 66/68) was the most common imaging modality, and primarily grey matter analyses were conducted (75%; 19/68). Some studies used multimodal analyses 44% (30/68). Genotype-associated imaging signatures are presented, innovative study designs are highlighted, common methodological shortcomings are discussed and lessons for future studies are outlined. Emerging academic observations have potential clinical implications for expediting the diagnosis, tracking disease progression and optimising the timing of pharmaceutical trials.
Regional variation in the GDP per capita of colonial Indonesia, 1870–1930
Authors: Bosma Ulbe , van Leeuwen Bas 
Published: August 2022

AbstractSince colonial times, substantial regional income disparities have been reported for Indonesia. However, in spite of a wide variety of available data and indicators, so far published data on Indonesian per capita GDP in colonial times are limited to macro-estimates for the entire archipelago or are confined either to Java or to the Outer Islands. In this paper we provide a first attempt to arrive at estimates of diverging income and living standards at a regional level. We implement the Geary and Stark method on a large body of data collected by the colonial government, to estimate GDP for ten macro-regions and five benchmark years between 1870 and 1930. Our findings, corrected for prices, confirm the image arising from the existing literature of major divergences within the Indonesian archipelago in general, and of a higher per capita GDP in most of the Outer Islands (all islands of the Indonesian archipelago except for Java and Madura) compared with Java in particular. This was definitely the case in 1870 and still the case in 1920, but the picture is less clear for 1930, which was the final year before Indonesia’s commodity exports started to collapse.
Value of Proline, Glutamic Acid, and Leucine-Rich Protein 1 and GATA Binding Protein 3 Expression in Breast Cancer: An Immunohistochemical study
Authors: Moustafa Manar , Ismael Magdy , Mohamed Salah , Hafez Abeer M. 
Published: August 2022

AbstractGATA binding protein 3 was more sensitive than traditional markers such as gross cystic disease fluid protein 15 and mammaglobin for identifying primary and metastatic breast carcinomas, but its significance decreased in triple-negative breast cancer. Recent studies showed a high expression rate of proline glutamic acid and leucine-rich protein in breast cancer and their superiority over GATA3 in triple-negative breast cancer. Our study provided new insights into the diagnostic and prognostic roles of PELP1 and GATA3 in primary and metastatic breast cancer. An immunohistochemical assay was carried out using PELP1 and GATA3 in 60 cases of primary breast cancer and 15 metastatic. Invasive carcinoma of no special type was the predominant type (80%). The majority of cases were grade 3 (68.3%). GATA3 expression was 83.3% positive in primary breast carcinomas and 73.5% positive in metastatic breast carcinomas. In comparison, PELP1 had a 96.7% positive expression rate in primary breast carcinomas and an 86.7% positive expression rate in metastasis. There was a statistically significant agreement between GATA3 and PELP1 in the diagnosis of the cases. PELP1 is a significantly higher proportion of both primary and metastatic breast carcinomas than GATA3. In breast cancer, there was a strong association between favorable prognostic factors and GATA3 expression, with evidence of an inverse association with Ki-67 overexpression.
Die mikrochirurgische Defektversorgung der Nase
Authors: Steiner C. , Bottini G. B. , Neubert M. , Nogami S. , Wittig J. , Brandtner C. , Gaggl A. 
Published: August 2022

ZusammenfassungTeil- oder Totalverluste der Nase führen zu ästhetischer Entstellung und zu hohem psychischen Leidensdruck sowie zu funktionellen Problemen im Bereich von Atmung und Geruchssinn. Aus rekonstruktiv-chirurgischer Sicht kann die Nase in drei Anteile geteilt werden: Innenauskleidung, Stützgerüst, Haut-Weichteil-Bedeckung. Im Rahmen der Rekonstruktion nasaler Defekte müssen alle drei Anteile bestmöglich wiederhergestellt werden. Je größer die Defekte sind, desto eher muss auf mikrovaskuläre Transplantate zurückgegriffen werden. Chondrokutane Transplantate von der Ohrhelix, gestielt an A. und V. temporalis superficialis, eignen sich sehr gut zur Rekonstruktion von Teildefekten der Nase. Osteoperiostale Transplantate vom medialen Femurkondylus, gestielt an A. descendens genus und Begleitvenen, eignen sich sehr gut zur Rekonstruktion des Nasenseptums oder des Nasenskeletts im Rahmen der Wiederherstellung großer Defekte. Der paramediane Stirnlappen stellt den Goldstandard zur Rekonstruktion großer Defekte der Haut-Weichteil-Bedeckung dar.