bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Role of a Detachment Fault in the Spatial Distribution of Ore-Bearing Paleofluid Flows in the Central Kolyma Region: A Nonconventional Approach to Predictive Metallogenic Modeling
Authors: Savchuk Yu. S. , Volkov A. V. 
Published: September 2022

Abstract—
The Central Kolyma region is the main gold-bearing part of the Verkhoyansk–Kolyma fold-and-thrust belt. Analysis of the developed geodynamic models of fold and thrust belt formation mechanisms, the Verkhoyansk–Kolyma belt in particular, suggests the leading role of subhorizontal movements on the detachment zone (decollement) at the base of an orogen as the “sole,” on which nappes detached at an early stage and with which major reverse strike-slip listric faults were directly associated at the collisional stage. In our opinion, the role of a detachment fault, the most important regional structure, is obviously underestimated in predictive metallogenic models. The detachment fault zone is complicated by transverse NE-trending faults, where its thickness and the fluid permeability can occur. The paper proposes a variant that links previously discovered gold deposits and occurrences in five gold mineralization strips along the inferred paleofluid flow routes. Here, the paleofluid flow route is the horizontal projection of the most probable migration pathway of released fluids from their generation zone to the ore deposition zone, which is drawn across the largest ore accumulations.
Eligibility for faricimab in a real-world neovascular age-related macular degeneration population: a cross-sectional study
Authors: Jern Iréne , Forsell Sara , Norberg Helena 
Published: September 2022

ObjectivesTo investigate the eligibility of a real-world neovascular age-related macular degeneration (nAMD) population for the TENAYA and LUCERNE trials (testing faricimab), and to compare the eligible real-world patients to trial participants.Design, settings and participantsIn this retrospective cross-sectional study, we used data from the Swedish Macula Registry (SMR) between 1 January 2017 and 31 December 2020. Persons were eligible if they fulfilled the main inclusion criteria in TENAYA and LUCERNE: (1) nAMD diagnosis, (2) treatment naïve, (3) ≥50 years and (4) best-corrected visual acuity (BCVA) of 78–24 letters.Main outcome measuresCharacteristics at the original visit of the eligible SMR population and baseline data from the clinical trials were compared.ResultsIn total, 27 962 individuals with nAMD were registered in SMR. A total of 15 399 (55%) individuals were treatment naïve; of these, 15 368 (55%) were ≥50 years and 13 265 (47%) also had BCVA of 78–24 letters and fulfilled eligibility. Among treatment-naïve individuals, 86% were eligible and the BCVA criterion was the most common reason for non-eligibility. The eligible SMR population was significantly older than either TENAYA or LUCERNE. SMR included more women and patients with worse visual acuity than TENAYA, while SMR patients were diagnosed more quickly than LUCERNE.ConclusionsAlmost half of the real-world nAMD population in SMR fulfilled the main inclusion criteria of the TENAYA and LUCERNE trials. Among treatment-naïve individuals, 86% were eligible. Marginally differences were shown between the eligible SMR population and the trial populations. The SMR population were older and more similar to the population in LUCERNE than TENAYA.
BND-22, a first-in-class humanized ILT2-blocking antibody, promotes antitumor immunity and tumor regression
Authors: Mandel Ilana , Haves Ziv Dana , Goldshtein Ilana , Peretz Tsuri , Alishekevitz Dror , Fridman Dror Anna , Hakim Motti , Hashmueli Sharon , Friedman Itay , Sapir Yair , Greco Rita , Qu Hongjing , Nestle Frank , Wiederschain Dmitri , Pao Lily , Sharma Sharad , Ben Moshe Tehila 
Published: September 2022

BackgroundCancer immunotherapy has revolutionized cancer treatment. However, considering the limited success of immunotherapy to only some cancer types and patient cohorts, there is an unmet need for developing new treatments that will result in higher response rates in patients with cancer. Immunoglobulin-like transcript 2 (ILT2), a LILRB family member, is an inhibitory receptor expressed on a variety of immune cells including T cells, natural killer (NK) cells and different myeloid cells. In the tumor microenvironment, binding of class I MHC (in particular HLA-G) to ILT2 on immune cells mediates a strong inhibitory effect, which manifests in inhibition of antitumor cytotoxicity of T and NK cells, and prevention of phagocytosis of the tumor cells by macrophages.MethodsWe describe here the development and characteristics of BND-22, a novel, humanized monoclonal antibody that selectively binds to ILT2 and blocks its interaction with classical MHC I and HLA-G. BND-22 was evaluated for its binding and blocking characteristics as well as its ability to increase the antitumor activity of macrophages, T cells and NK cells in various in vitro, ex vivo and in vivo systems.ResultsCollectively, our data suggest that BND-22 enhances activity of both innate and adaptive immune cells, thus generating robust and comprehensive antitumor immunity. In humanized mice models, blocking ILT2 with BND-22 decreased the growth of human tumors, hindered metastatic spread to the lungs, and prolonged survival of the tumor-bearing mice. In addition, BND-22 improved the antitumor immune response of approved therapies such as anti-PD-1 or anti-EGFR antibodies.ConclusionsBND-22 is a first-in-human ILT2 blocking antibody which has demonstrated efficient antitumor activity in various preclinical models as well as a favorable safety profile. Clinical evaluation of BND-22 as a monotherapy or in combination with other therapeutics is under way in patients with cancer.Trial registration numberNCT04717375.
Unveiling the tumor immune microenvironment of organ-specific melanoma metastatic sites
Authors: Conway Jordan W , Rawson Robert V , Lo Serigne , Ahmed Tasnia , Vergara Ismael A , Gide Tuba N , Attrill Grace Heloise , Carlino Matteo S , Saw Robyn P M , Thompson John F , Spillane Andrew J , Shannon Kerwin F , Shivalingam Brindha , Menzies Alexander Maxwell , Wilmott James S , Long Georgina V , Scolyer Richard A , Pires da Silva Ines 
Published: September 2022

BackgroundThe liver is a known site of resistance to immunotherapy and the presence of liver metastases is associated with shorter progression-free and overall survival (OS) in melanoma, while lung metastases have been associated with a more favorable outcome. There are limited data available regarding the immune microenvironment at different anatomical sites of melanoma metastases. This study sought to characterize and compare the tumor immune microenvironment of liver, brain, lung, subcutaneous (subcut) as well as lymph node (LN) melanoma metastases.MethodsWe analyzed OS in 1924 systemic treatment-naïve patients with AJCC (American Joint Committee on Cancer) stage IV melanoma with a solitary site of organ metastasis. In an independent cohort we analyzed and compared immune cell densities, subpopulations and spatial distribution in tissue from liver, lung, brain, LN or subcut sites from 130 patients with stage IV melanoma.ResultsPatients with only liver, brain or bone metastases had shorter OS compared to those with lung, LN or subcutaneous and soft tissue metastases. Liver and brain metastases had significantly lower T-cell infiltration than lung (p=0.0116 and p=0.0252, respectively) and LN metastases (p=0.0116 and p=0.0252, respectively). T cells were further away from melanoma cells in liver than lung metastases (p=0.0335). Liver metastases displayed unique T-cell profiles, with a significantly lower proportion of programmed cell death protein-1+ T cells compared to all other anatomical sites (p<0.05), and a higher proportion of TIM-3+ T cells compared to LN (p=0.0004), subcut (p=0.0082) and brain (p=0.0128) metastases. Brain metastases had a lower macrophage density than subcut (p=0.0105), liver (p=0.0095) and lung (p<0.0001) metastases. Lung metastases had the highest proportion of programmed death ligand-1+ macrophages of the total macrophage population, significantly higher than brain (p<0.0001) and liver metastases (p=0.0392).ConclusionsLiver and brain melanoma metastases have a significantly reduced immune infiltrate than lung, subcut and LN metastases, which may account for poorer prognosis and reduced immunotherapy response rates in patients with liver or brain metastases. Increased TIM-3 expression in liver metastases suggests TIM-3 inhibitor therapy as a potential therapeutic opportunity to improve patient outcomes.
Automated, scaled, transposon-based production of CAR T cells
Authors: Lock Dominik , Monjezi Razieh , Brandes Caroline , Bates Stephan , Lennartz Simon , Teppert Karin , Gehrke Leon , Karasakalidou-Seidt Rafailla , Lukic Teodora , Schmeer Marco , Schleef Martin , Werchau Niels , Eyrich Matthias , Assenmacher Mario , Kaiser Andrew , Prommersberger Sabrina , Schaser Thomas , Hudecek Michael 
Published: September 2022

BackgroundThere is an increasing demand for chimeric antigen receptor (CAR) T cell products from patients and care givers. Here, we established an automated manufacturing process for CAR T cells on the CliniMACS Prodigy platform that is scaled to provide therapeutic doses and achieves gene-transfer with virus-free Sleeping Beauty (SB) transposition.MethodsWe used an advanced CliniMACS Prodigy that is connected to an electroporator unit and performed a series of small-scale development and large-scale confirmation runs with primary human T cells. Transposition was accomplished with minicircle (MC) DNA-encoded SB100X transposase and pT2 transposon encoding a CD19 CAR.ResultsWe defined a bi-pulse electroporation shock with bi-directional and unidirectional electric field, respectively, that permitted efficient MC insertion and maintained a high frequency of viable T cells. In three large scale runs, 2E8 T cells were enriched from leukapheresis product, activated, gene-engineered and expanded to yield up to 3.5E9 total T cells/1.4E9 CAR-modified T cells within 12 days (CAR-modified T cells: 28.8%±12.3%). The resulting cell product contained highly pure T cells (97.3±1.6%) with balanced CD4/CD8 ratio and a high frequency of T cells with central memory phenotype (87.5%±10.4%). The transposon copy number was 7.0, 9.4 and 6.8 in runs #1–3, respectively, and gene analyses showed a balanced expression of activation/exhaustion markers. The CD19 CAR T cell product conferred potent anti-lymphoma reactivity in pre-clinical models. Notably, the operator hands-on-time was substantially reduced compared with conventional non-automated CAR T cell manufacturing campaigns.ConclusionsWe report on the first automated transposon-based manufacturing process for CAR T cells that is ready for formal validation and use in clinical manufacturing campaigns. This process and platform have the potential to facilitate access of patients to CAR T cell therapy and to accelerate scaled, multiplexed manufacturing both in the academic and industry setting.
Anti-RA33 antibodies are present in a subset of patients with immune checkpoint inhibitor-induced inflammatory arthritis
Authors: Cappelli Laura C , Bingham Clifton O , Forde Patrick M , Anagnostou Valsamo , Brahmer Julie , Lipson Evan J , Mammen Jennifer , Schollenberger Megan , Shah Ami A , Darrah Erika 
Published: September 2022

ObjectivePatients with inflammatory arthritis (IA) associated with immune checkpoint inhibitor (ICI) treatment for cancer are typically seronegative for anti-cyclic citrullinated peptide (CCP) antibodies and rheumatoid factor, but little is known about the presence of other autoantibodies in this patient population. We investigated the prevalence and characteristics of anti-RA33 antibodies in patients with ICI-induced IA.MethodsAnti-RA33 ELISAs were performed on sera from four groups of patients: 79 with ICI-induced IA, 52 with rheumatoid arthritis (RA), 35 treated with ICIs without IA during follow-up and 50 healthy controls. Anti-RA33 positivity and level, clinical and demographic data were compared across groups.ResultsAnti-RA33 antibodies were found in 9/79 (11.4%) patients with ICI-induced IA but in 0/35 patients treated with ICIs who did not develop IA (0%; p=0.04). Of the patients positive for anti-RA33, two had sera available from before ICI treatment; anti-RA33 antibodies were present in both pre-ICI treatments. In patients with RA, 7.7% were positive for anti-RA33 antibodies as were 2% of healthy controls. In ICI-induced IA, anti-RA33 antibodies were associated with anti-CCP antibodies (p=0.001). We found no statistically significant differences in other clinical characteristics in those with and without anti-RA33 antibodies.ConclusionsAnti-RA33 antibodies are present in a subset of patients with ICI-induced IA, absent in other ICI-treated patients and may be a biomarker for developing IA. Additional studies evaluating serial samples before and after ICI treatment will further establish the temporal relationship of these antibodies to IA development.
Swampland criteria for f(R) gravity derived with a Gaussian process
Authors: Elizalde Emilio , Khurshudyan Martiros 
Published: September 2022

AbstractA Gaussian Process (GP) is used to derive Swampland criteria for f(R) modifications of General Relativity (GR). The fact that observational data are directly taken into account allows obtaining clean upper and lower limits for the Swampland criteria, in an unbiased, natural way. They correspond to a dark-energy dominated Universe, having assumed the form of the f(R) gravity, only. To perform this study, 40-point H(z) data are used, consisting of 30-point samples deduced from the differential age method, and 10-point additional samples coming from the radial BAO method. The constraints obtained for each f(R) model parameter choice indicate whether it is possible to alleviate the $$H_{0}$$

H
0

tension problem efficiently due to the used $$H_{0}$$

H
0

values reported by the Planck and Hubble missions. The elaborated structure of the analysis forced to limit the number of specific models, but the methodology here discussed is applicable to study any form of f(R) gravity.
THE INFLUENCE OF HEIGHT ON TEST-RETEST RELIABILITY OF POSTURAL BALANCE MEASURES IN HEALTHY YOUNG ADULTS
Authors: EOM GWANG-MOON , KWON YU-RI , KIM DONG-YEON , KO JUNGHYUK , KIM JI-WON 
Published: September 2022

Height is associated with postural balance performance. However, there has been no study on whether the test-retest reliability of the balance performance variables is related to height. The goal of our study was to analyze the effect of body height on the test-retest reliability of center of pressure (COP) variables during natural and feet-together stances in healthy young subjects. Twenty normal young men were classified into the short height group (height range, 163–174[Formula: see text]cm) and the tall height group (height range, 176–184[Formula: see text]cm) with 10 subjects each to investigate the influence of height on test-retest reliability. All subjects performed the static balance test on a commercial force plate in feet-together and natural stance conditions three times. Four variables were calculated from the COP data. COP distance, COP area, COP velocity, and COP mean frequency were selected as the postural balance variables. Intraclass correlation coefficient (ICC) was evaluated for an analysis of the test-retest reliability of each COP variable. In both stance conditions, the COP distance and the COP area in the short height group (ICC = 0.717–0.902) showed better test-retest reliability compared to those in the tall height group (ICC = 0.146–0.688). COP velocity had the highest ICC value in both stance conditions (ICC = 0.744–0.970). Additionally, the short height group showed slightly better reliability in the feet-together stance condition, whereas the tall height group showed slightly higher ICC value in the natural stance condition. These results suggest that height should be considered for a more reliable assessment of repetitive static balance performance. Our findings might be useful for the development of an optimal static balance test protocol regardless of the effect of height.
Mobility Inference on Long-Tailed Sparse Trajectory
Authors: Shi Lei , Luo Yuankai , Ma Shuai , Tong Hanghang , Li Zhetao , Zhang Xiatian , Shan Zhiguang 
Published: September 2022

Analyzing the urban trajectory in cities has become an important topic in data mining. How can we model the human mobility consisting of stay and travel states from the raw trajectory data? How can we infer these mobility states from a single user’s trajectory information? How can we further generalize the mobility inference to the real-world trajectory data that span multiple users and are sparsely sampled over time?
In this article, based on formal and rigid definitions of the stay/travel mobility, we propose a single trajectory inference algorithm that utilizes a generic long-tailed sparsity pattern in the large-scale trajectory data. The algorithm guarantees a 100% precision in the stay/travel inference with a provable lower bound in the recall metric. Furthermore, we design a transformer-like deep learning architecture on the problem of mobility inference from multiple sparse trajectories. Several adaptations from the standard transformer network structure are introduced, including the singleton design to avoid the negative effect of sparse labels in the decoder side, the customized space-time embedding on features of location records, and the mask apparatus at the output side for loss function correction. Evaluations on three trajectory datasets of 40 million urban users validate the performance guarantees of the proposed inference algorithm and demonstrate the superiority of our deep learning model, in comparison to sequence learning methods in the literature. On extremely sparse trajectories, the deep learning model improves from the single trajectory inference algorithm with more than two times of overall and F1 accuracy. The model also generalizes to large-scale trajectory data from different sources with good scalability.
"Triangular: arte deste século": a coleção de arte contemporânea brasileira no Museu Universitário
Authors: Avelar Ana Candida , Zaiden Victor 
Published: September 2022

Este artigo apresenta e analisa o processo de formação e difusão da coleção de arte contemporânea Triangular: arte deste século, pertencente à Casa de Cultura da América Latina da Universidade de Brasília (UnB), trabalho conjunto entre professores, estudantes e servidores que ocorreu entre agosto de 2019 e março de 2021. Buscamos consolidar nessa publicação os preceitos teórico-metodológicos que orientaram não apenas os eixos curatoriais que originaram a coleção e a exposição de mesmo nome, realizada na Casa Niemeyer, mas também os processos de aprendizagem envolvendo a participação de estudantes ao longo de todas as fases do trabalho. Também se leva em conta o desenvolvimento do projeto Casa Niemeyer Digital, constituído por estratégias adotadas para explorar e difundir as potencialidades da coleção a partir dos meios virtuais, como resposta à limitação de visitas presenciais aos museus imposta pela pandemia da covid‑19.
It’s a Performance, Not an Orchestra! Rethinking Soft Coordination in Global Climate Governance
Authors: Aykut Stefan C. , Schenuit Felix , Klenke Jan , d’Amico Emilie 
Published: September 2022

Abstract
Global climate governance is in transition. As the focus shifts from negotiations to implementation, the quest for ways to effectively coordinate ambitious climate action has become a key concern. While existing studies frame this problem mostly in terms of institutional design (to “facilitate” state ambition) and strategic delegation of authority (to “orchestrate” nonstate action), this article builds on dramaturgical policy analysis to examine soft coordination in practice. Using ethnographic methods, we analyze public performances at the twenty-fifth Conference of the Parties (COP25) in Madrid. We find that these were shaped by preestablished governance scripts and social roles available to participants, but also by creative improvisations and interventions. The United Nations Framework Convention on Climate Change Secretariat and COP Presidency intervened to configure the physical setting of the conference, mold its narrative arch, and shape available roles. We conclude that performances and dramaturgical interventions are important tools of soft coordination in global climate governance. Their analysis constitutes a productive entry point for grasping contemporary transformations in global politics.
Study of the adsorption mechanisms of NH3, H2S and SO2 on sepiolite using molecular dynamics simulations
Authors: Zhou Ji , Wang Zuozhang , Alcântara Ana C.S. , Ding Yanhuai 
Published: September 2022

AbstractThe adsorption mechanisms of hazardous gas molecules such as NH3, H2S and SO2 on sepiolite have not yet been elucidated. Therefore, molecular dynamics (MD) simulations were employed to investigate the adsorption behaviour of sepiolite towards NH3, H2S and SO2. A calculation model for sepiolite containing structural and zeolitic water molecules was constructed in this study. The adsorption sites and molecular configurations of the hazardous gases in the sepiolite channels were studied. The radial distribution function was employed to evaluate the interactions between the gas molecules and sepiolite. The results show that the order of adsorption capacity of sepiolite for the gases is as follows: SO2 > H2S > NH3. These three types of gas molecules absorbed in the channel nanopores of sepiolite exhibit different atomic configurations. The diffusion coefficients of the gas molecules in the channels decreased in the following order: NH3 > H2S > SO2. In addition, the diffusion coefficients were affected significantly by the ratio of the number of gas/water molecules. This study provides new perspectives for understanding the molecular processes responsible for the adsorption properties of sepiolite.