bluuebunny/crossref_metadata_2025_split huggingface dataset:
Distributed Cross‐Domain Link Creation for Flexible Data Integration and Manageable Data Interoperability Standards
Authors: Reichwein Axel 
Published: April 2022

ABSTRACTA distributed link creation strategy represents a shift from the traditional centralized link creation strategy used for data integration. A distributed link creation strategy provides a more flexible, user‐friendly approach for engineers to specify cross‐domain links between different domains of engineering data, which is key to achieving traceability across different product lifecycle phases. A new type of API that allows API clients to find link targets easily and create links makes this possible. Features of this new link‐enabling API include support for the open‐world assumption, embeddable search dialogs, and hypermedia for self‐discovery. Furthermore, a distributed link creation strategy also supports more efficient standardization efforts to achieve data interoperability by only requiring small, thus more manageable, domain‐specific standards in combination with standardized cross‐domain links, in contrast to the typically large, therefore unmanageable, multi‐domain standards.
Cultural responsiveness in applied behavior analysis: Research and practice
Authors: Jimenez‐Gomez Corina , Beaulieu Lauren 
Published: April 2022

The new Ethics Code for Behavior Analysts requires that certificants engage in training related to culturally responsive service delivery (BACB, 2020). There is limited work in the area of culturally responsive evidence‐based practice within our field. Therefore, it is incumbent on researchers and practitioners to identify best practices for working with diverse populations. Hence, the purpose of this paper is three‐fold: a) to review research within and outside the field of ABA related to culturally responsive assessment and treatment and provide practice recommendations, b) to examine the extent to which current practices in behavior assessment and treatment align with aspects of culturally responsive practices, and c) to inspire research in the areas of behavior assessment and treatment to identify best practices with regard to culturally responsive behavior analytic practices. The content of this paper is grounded in the framework described by Beaulieu and Jimenez‐Gomez (2022).
2,3′,4,4′,5‐Pentachlorobiphenyl attenuated fast‐twitch fibers and fiber size of skeletal muscle via disturbing thyroid hormone signaling and mitochondrial dynamics
Authors: Zhu Xiaoxia , Zou Yuxin , Qi Xinyu , Sheng Yunlu , Lv Shan , Yu Jing , Wang Xiaodong , Ding Guoxian , Duan Yu 
Published: April 2022

AbstractPolychlorinated biphenyls (PCBs) affect multiple organs, and some of the effects are mediated by interfering with thyroid hormone (TH) signaling that regulates physiological processes in mammals. It remains unclear how PCBs affect skeletal muscle (SM). In our study, wistar rats were injected 2,3′,4,4′,5‐pentachlorobiphenyl (PCB118) intraperitoneally at 0, 10, 100, and 1000 μg/kg/day for 13 weeks, and C2C12 myoblasts were treated PCB118 (0, 0.25, 25, and 50 nM) for 24 h or 48 h. We found that myocyte cross‐sectional area (MCSA) was reduced, MyHC IIa and MyHC IIb mRNA levels significantly decreased, and muscle strength was weakened in PCB118‐exposed rats. TH receptor α (TRα) and iodothyronine deiodinase type 2 (DIO2) were upregulated after PCB118 exposure both in vivo and in vitro. Transmission electron microscopy showed significant mitochondrial abnormalities in PCB118‐treated rats, and the expression of mitochondrial regulators such as PTEN‐induced kinase 1 (PINK1) and GTPase dynamin‐related protein 1 (DRP1) were altered after PCB118 exposure. These results suggest that PCB118 could weaken muscle strength and attenuate fast‐twitch fibers and fiber size of SM in rats. TH signaling, mitochondrial dynamics and mitophagy were also disturbed by PCB118, which may contribute to the alternations of SM structure and function.
Inhibition of scopolamine‐induced memory and mitochondrial impairment by betanin
Authors: Salimi Ahmad , Sabur Meysam , Dadkhah Masoomeh , Shabani Mohammad 
Published: April 2022

AbstractMitochondrial dysfunction and oxidative stress are identified to contribute to the mechanisms responsible for the pathogenesis of Alzheimer's disease (AD). Scopolamine (SCO) as a potent drug for inducing memory and learning impairment is associated with mitochondrial dysfunction and oxidative stress. In AD clinical trials molecules with antioxidant properties have shown modest benefit. Betanin as a multifunctional molecule with powerful antioxidative properties may be effective in the treatment of neurodegenerative. Hence, this study was designed to investigate the possible therapeutic effect of betanin against SCO‐induced AD on Wistar rats. SCO (1 mg/kg) was administrated intraperitoneally to induce the AD in Wistar rats. The rats were treated with betanin doses (25 mg/kg and 50 mg/kg) intraperitoneally for 9 consecutive days. At the end of the 9th day, the animals were subjected to behavioral examination such as novel object recognition and passive avoidance tests and killed to study the mitochondrial and histological parameters. The results showed attenuation of SCO‐induced memory and learning impairment by betanin at 50 mg/kg dose. Also, mitochondrial toxicity parameters such as mitochondrial membrane potential collapse, mitochondrial swelling, decreased activity of succinate dehydrogenase, and reactive oxygen species (ROS) production were reversed by betanin (50 mg/kg) compared to the SCO group. In addition, the ameliorative effect of betanin against SCO was demonstrated in histopathological results of hippocampus. The present investigation established that the betanin ameliorates the SCO‐induced memory impairments, tissue injuries, and mitochondrial dysfunction by reducing mitochondrial ROS, which may be due to the potent antioxidant action of betanin.
Trans‐cleaving hammerhead ribozyme in specific regions can improve knockdown efficiency in vivo
Authors: Peng Yan , Ai Xilei , Peng Bo 
Published: April 2022

AbstractTrans‐cleaving techniques have been most enthusiastically embraced in the development of therapy for genetic diseases, particularly in the correction of monogenic recessive mutations at the messenger RNA level. However, easy degradation and poor catalytic activity in vivo remain significant obstacles to trans‐cleaving of the hammerhead ribozyme. Herein, we found a novel scaffold RNA that stabilizes the ribozyme structure in trans‐cleaving and promotes the knockdown efficiency of the hammerhead ribozyme in specific regions of living cells. We can give the trans‐cleaving hammerhead ribozyme the ability to knock down specific genes in specific cell regions by changing different scaffolds. Therefore, our study proves the potential usefulness of the RNA knockdown strategy with high‐specific trans‐cleaving hammerhead ribozyme as a therapeutic approach in gene therapy.
The power of compassion in group psycotherapy
Authors: Griner Derek , Erekson David M. , Beecher Mark E. , Cattani Kara , Burlingame Gary M. 
Published: April 2022

AbstractResearch has repeatedly demonstrated that individual and group psychotherapy are equally effective. Compassion‐focused therapy (CFT) has been shown to be an effective approach to treating individuals with a wide range of presenting mental health concerns. In this study, we discuss the basic tenets of CFT and introduce a 12‐module CFT group psychotherapy approach for college counseling centers. We use a clinical vignette to provide an example of how psychotherapists may implement this approach. We then discuss clinical applications, including strengths and limitations of this approach.
Light and scanning electron microscopic characterization of pollen grains of some wetland angiosperms from India
Authors: Paul Payel , Dhar Sayantan , Das Dipayan , Chowdhury Monoranjan 
Published: April 2022

AbstractPollen grains of 58 wetland species of angiosperms belonging to 17 families, growing in different wetlands of Sub‐Himalayan biodiversity hotspots, Northern Bengal and lower Gangetic plains, India were investigated during a 4‐year span of 2015–2019. Freshly collected anthers were processed through the acetolysis method and the obtained pollen grains were accurately studied under LM and SEM and properly photographed. Different attributes viz. shape, size, aperture type and exine ornamentation of pollen grains served as consistent features were used for authentic identification of the studied species. To study the phylogeny of pollen grains, characters like polarity, symmetry, aperture and exine sculpturing were found most significant for species segregation. Investigated pollen grains were mostly prolate‐spheroidal, spheroidal or triangular, rarely prolate or elongated, exine psilate, granulate, reticulate or microechinate type. Most of the observable aperture of pollen grains of studied species were colporate, colpate and porate, while ulcerate and inaperturate grains were also observed in the studied aquatic members of the families Cyperaceae and Potamogetonaceae. All the gathered data were further statistically analyzed through ANOVA, PCA and Pearson Correlation Matrix to understand the interrelationship among the species. The permanent slides of identified pollen grains were deposited at the herbarium of North Bengal University [NBU] for future references.HighlightsStudy of Pollen morphology of 58 wetland species under light & scanning electron microscopy. Unique apertures and exine ornamentation used to understand taxonomic evaluation of studied species. Pollen character supports interrelationship among the studied species. Relationship between exine thickness and the habitat of the wetland plants.
Management of pregnancy in a patient with long‐chain 3‐hydroxyacyl CoA dehydrogenase deficiency
Authors: Shakerdi Loai A. , McNulty Jenny , Gillman Barbara , McCarthy Claire M. , Ivory Jessica , Sheerin Alison , O'Byrne James J. , Donnelly Jennifer C. , Treacy Eileen P. 
Published: April 2022

AbstractLong‐chain 3‐hydroxyacyl‐CoA dehydrogenase deficiency (LCHADD) is a rare mitochondrial defect of β‐oxidation of long‐chain fatty acids. Patients may present with muscle pain, hypotonia, peripheral neuropathy, cardiomyopathy, recurrent rhabdomyolysis and sudden death. Dietary management of LCHADD aims at preventing prolonged fasting and decreasing energy production from long‐chain fatty acids compensated by an increase in medium‐chain triglyceride fat. Herein, we present medical and dietetic management of a successful pregnancy in a LCHADD female patient and the delivery of a healthy baby boy.
Effects of COVID‐19 lockdown on arrhythmias in patients with implantable cardioverter‐defibrillators in southern Italy
Authors: Ducceschi Valentino , de Divitiis Marcello , Bianchi Valter , Calvanese Raimondo , Covino Gregorio , Rapacciuolo Antonio , Russo Vincenzo , Canciello Michelangelo , Volpicelli Mario , Ammirati Giuseppe , Sangiuolo Raffaele , Papaccioli Giovanni , Ciardiello Carmine , Innocenti Sara , D'Onofrio Antonio 
Published: April 2022

AbstractBackgroundThe effects of lockdown on non‐COVID patients are varied and unexpected. The aim is to evaluate the burden of cardiac arrhythmias during a lockdown period because of COVID‐19 pandemics in a population implanted with cardiac defibrillators and followed by remote monitoring.MethodsIn this retrospective, multicentre cohort study, we included 574 remotely monitored implantable cardioverter defibrillator (ICD) and cardiac resynchronization therapy‐defibrillator (CRT‐D) recipients implanted before January 1, 2019, at seven hospitals in the Campania region, comparing the burden of arrhythmias occurred during the lockdown period because of COVID‐19 epidemics (from March 9 to May 1, 2020) with the arrhythmias burden of the corresponding period in 2019 (reference period). Data collection was performed through remote monitoring.ResultsDuring the lockdown period, we observed ventricular tachyarrhythmias (ventricular tachycardia or fibrillation) in 25 (4.8%) patients while in seasonal reference period we documented ventricular tachyarrhythmias in 12 (2.3%) patients; the comparison between the periods is statistically significant (P < .04). Atrial arrhythmias were detected in 38 (8.2%) subjects during the lockdown period and in 24 (5.2%) during the reference period (P < .004).ConclusionIn seven hospitals in the Campania region, during the pandemic lockdown period, we observed a higher burden of arrhythmic events in ICD/CRT‐D patients through device remote monitoring.
The power of benevolence: The joint effects of contrasting leader values on follower‐focused leadership and its outcomes
Authors: Sverdlik Noga , Oreg Shaul , Berson Yair 
Published: April 2022

SummaryThe most frequent approach to studying leader attributes has been to demonstrate links between separate dispositions (e.g., traits and values) and leader behavior. Yet, both in the field of personality overall and the field of personal values in particular, there is a growing understanding that to more realistically capture the effects of personality, one needs to study the joint effects of personality dimensions, rather than their separate ones. In the present studies, we demonstrate how a combination of values predicts leaders' follower‐focused behavior and its outcomes. Specifically, we demonstrate that the combination of leaders' power and benevolence values predicts leaders' follower‐focused leadership and follower outcomes. In Study 1, the interaction between 75 school leaders' power and benevolence predicted followers' reports (N = 293) of their leaders' follower‐focused leadership, such that the relationship between power values and follower‐focused leadership was positive and significant only among leaders high on benevolence values. We replicated this effect in Study 2 with data collected in two points in time, from 76 principals and 494 of their subordinates. We also demonstrated the indirect effect of principals' values, through their follower‐focused leadership, on teachers' satisfaction and nurturing behavior.
Compounding precipitation effect in modulating maize yield response to global warming
Authors: Ban Yunyun , Leng Guoyong , Tang Qiuhong 
Published: April 2022

AbstractHigh temperature generally causes large‐scale crop yield reduction, and such negative effects are known to depend on the concurrent precipitation. However, the compounding precipitation effect in regulating crop yield response to global warming remains under‐examined. This research aims to evaluate the role of concurrent changes in precipitation in modulating global maize yield response to temperature under 1.5 and 2.0 K temperature rise for RCP 4.5 and 8.5 scenarios, respectively. Empirical linear function is adopted to calculate the function parameters and impact of precipitation modulation based on global census data on maize yield and climate in the baseline period of 1980–2010. The sensitivity of maize yield to temperature is then estimated under condition that with and without removal of precipitation impact. The maize yield sensitivity to temperature is negative in most rain‐fed growing areas in the baseline period of 1980–2010, and the global sensitivity is −9.39%/K if the precipitation impact is considered or −6.92%/K if the precipitation impact is removed. Globally, approximately 30% of the observed strength of relationship between maize yield and temperature is induced by the compounding precipitation effect. Under 1.5 and 2.0 K warming scenarios, global maize yield is projected to decrease by −10.16% to −11.91% and −15.01% to −17.14%, respectively. The world maize yield differences between 1.5 and 2.0 K scenarios will be −4.85% and −5.23% without the compounding precipitation effect and range from −3.52% to −3.89% with the compounding precipitation effect, to which the contribution of compounding precipitation increases to 35%. The modulating impacts of precipitation are the strongest in high latitude countries, while weak effects are found in Argentina, China, India, and South Africa. The research can help us understand the important but uncertain issue that how much the maize yield response to global warming is contributed by the compounding precipitation effect.
UHPLC‐Q‐Orbitrap‐based untargeted lipidomics reveals the variation of yolk lipids during egg storage
Authors: Meng Yaqi , Qiu Ning , Guyonnet Vincent , Keast Russell , Zhu Chunxia , Mine Yoshinori 
Published: April 2022

AbstractBACKGROUNDEgg yolk is recognized for its excellent nutritional benefit and economic value; however, egg is a perishable food, potentially losing quality if not handled properly between the time from farm production to consumption. Knowledge of the changes of yolk lipid composition under an extreme storage condition close to vitelline membrane breaking, which results in an inedible condition for shelf‐eggs, remains incomplete. Considering the complexity of yolk lipids, the architectural features of yolk lipids at high‐temperature storage (30°C for 10 days versus fresh) were classified through lipidomics.RESULTSThis strategy yielded 1508 features within the lipid database coupled with 74 significantly different lipids (P < 0.05, fold change > 1.2 or < 0.83), mainly triglycerides, phospholipids, and sphingolipids. Most of them were decreased after storage; for example, triglycerides were assumed to play a role as a ‘buffer’ to maintain the system stability during storage by balancing fatty acid saturation, which strongly reduces the egg edible value for humans. Furthermore, phospholipids, especially the highly unsaturated phosphatidylcholine, decreased significantly and were suggested to be the primary cause for the variation in yolk emulsifying properties and flavor.CONCLUSIONAltogether, these results deriving from oxidation and lipolysis reactions enhance our understanding of lipid transformation and the biochemical mechanisms, at the molecular level, of the deteriorative process of the egg yolk. These findings may lay the foundation for identifying processes, including some modifications of the lipid composition of rations fed to laying hens, aiming to improve the long‐term shelf‐stability of shell eggs and egg products. © 2022 Society of Chemical Industry.
Solvent terminated natural deep eutectic solvent microextraction for concentration of curcuminoids in Curcumae Longae Rhizoma and turmeric tea
Authors: Yang Li , Xie Li‐yuan , Chen Xuan , Bai Xiao‐hong , Hu Shuang 
Published: April 2022

A novel solvent terminated microextraction method based on a natural deep eutectic solvent (L‐menthol and lactic acid at a molar ratio of 1:2) coupled with high‐performance liquid chromatography was proposed, which was utilized for the separation and enrichment of bisdemethoxycurcumin, demethoxycurcumin and curcumin in Curcumae Longae Rhizoma and turmeric tea. The effects of independent parameters on extraction efficiency were optimized by single‐factor analysis. Subsequently, four predominated parameters affecting the extraction procedure, including extractant volume, salt concentration, demulsifier consumption, and demulsification time, were further evaluated by a central composite design. Under the optimized conditions, the linear ranges of calibration curves were 0.005–0.5 μg/mL for bisdemethoxycurcumin, 0.004–0.4 μg/mL for demethoxycurcumin, and 0.0045–0.45 μg/mL for curcumin, respectively. In addition, the developed method provided low detection limits (0.1–0.4 ng/mL) and high enrichment factors (279–350). Its intra‐day and inter‐day precision were carried out by relative standard deviation ranging from 2.2 to 9.2%. Finally, the applicability of this method was assessed by the analysis of Curcumae Longae Rhizoma and turmeric tea samples. The results showed that these samples were detected successfully and the spiked recoveries over the range of 85.3‐108.9% with relative standard deviations of 1.6‐8.9% were attained, indicating its high relative recoveries with good precision in real sample analysis.
Spatial risk modeling of cattle depredation by black vultures in the midwestern United States
Authors: Quinby Brandon M. , Kluever Bryan M. , Burcham Grant N. , Humberg Lee A. , Jones Landon R. , Wahl Marian L. , Zollner Patrick A. 
Published: April 2022

AbstractNegative economic impacts resulting from wildlife disrupting livestock operations through depredation of stock are a cause of human‐wildlife conflict. Management of such conflict requires identifying environmental and non‐environmental factors specific to a wildlife species' biology and ecology that influence the potential for livestock depredation to occur. Identification of such factors can improve understanding of the conditions placing livestock at risk. Black vultures (Coragyps atratus) have expanded their historical range northward into the midwestern United States. Concomitantly, an increase in concern among agricultural producers regarding potential black vulture attacks on livestock has occurred. We estimated area with greater or lesser potential for depredation of domestic cattle by black vultures across a 6‐state region in the midwestern United States using an ensemble of small models (ESM). Specifically, we identified landscape‐scale spatial factors, at a zip code resolution, associated with reported black vulture depredation on cattle in midwestern landscapes to predict future potential livestock depredation. We hypothesized that livestock depredation would be greatest in areas with intensive beef cattle production close to preferred black vulture habitat (e.g., areas with fewer old fields and early successional vegetation paired with more direct edge between older forest and agricultural lands). We predicted that the density of cattle within the county, habitat structure, and proximity to anthropogenic landscape features would be the strongest predictors of black vulture livestock‐depredation risk. Our ESM estimated the relative risk of black vulture‐cattle depredation to be between 0.154–0.631 across our entire study area. Consistent with our hypothesis, areas of greatest predicted risk of depredation correspond with locations that are favorable to vulture life‐history requirements and increased potential to encounter livestock. Our results allow wildlife managers the ability to predict where black vulture depredation of cattle is more likely to occur in the future. It is in these areas where extension and outreach efforts aimed at mitigating this conflict should be focused. Researchers and wildlife managers interested in developing or employing tools aimed at mitigating livestock‐vulture conflicts can also leverage our results to select areas where depredation is most likely to occur.
Molecularly Imprinted Nanoparticles Synthesized by Electrochemically Mediated Atom Transfer Radical Precipitation Polymerization
Authors: Pu Hang , Xu Lan 
Published: April 2022

AbstractNanometer molecularly imprinted polymers (nano‐MIPs) spherical particles with specific recognition of sialic acid (SA) are synthesized by electrochemically mediated atomic transfer radical polymerization combined with the precipitation method. SA is used as template molecules,4‐vinylphenylboronicacid as functional monomer, and ethylene glycol dimethacrylate as the crosslinking agent. The successful synthesis of spherical nano‐MIPs is verified by Fourier transform infrared spectroscopy, scanning electron microscope, and Malvern particle size instruments. The effects of the potential adjustment on the morphology, size, and particle size distribution of MIP particles are further investigated. By adjusting the potential for polymerization, nanoparticles with average sizes of 160.32, 275.87, and 331.99 nm are obtained. The recognition performance of nano‐MIPs for SA is characterized by a UV–vis spectrophotometer and the satisfactory imprinting factor is 1.54.