bluuebunny/crossref_metadata_2025_split huggingface dataset:
Profitability of Ichimoku-based trading rule in Vietnam stock market in the context of the COVID-19 outbreak
Authors: Che-Ngoc Ha , Do-Thi Nga , Nguyen-Trang Thao 
Published: September 2022

Abstract
Ichimoku Kinkohyo or Ichimoku Cloud Chart is one of the most popular technical indicators used by traders all over the world. However, its profitability is heavily influenced by the market environment, to which it is applied. Furthermore, the COVID-19 outbreak may have an impact on the market environment as well as the performance of all technical indicators. This study is the first to look into the profitability of Ichimoku-based trading rules in the Vietnamese stock market in the context of the COVID-19 outbreak. More particularly, the COVID-19 outbreak has a positive influence on the performance of this strategy when applied to the four industries consisting of real estate industry, food and beverage industry, resource industry, and automotive and electronic components industry. The obtained results demonstrate that the Ichimoku-based strategy can be considered a suitable method for applying Vietnam stock market, indeed no matter if there would be adverse effects of the pandemic on the industries or not.
De-epithelialized overlap flap to secure urethroplasty in second stage hypospadias repair: Revisiting the Smith technique
Authors: AbouZeid Amr Abdelhamid , Habak Reda Abualyazeed , Hamad Mostafa Mahmoud , Shahin Alaa-Eldin Medhat 
Published: September 2022

Abstract
Background: The application of a second layer between the neourethra and skin was a major contribution, which has improved the outcome of hypospadias repair. Here, we report our experience of revisiting the original Smith technique using a de-epithelialized overlap flap to support the urethroplasty in staged hypospadias repair.
Methods: The study included primary cases of proximal hypospadias with significant chordee who underwent two-stage repair during the period 2016 through 2021.
The ventral curvature was corrected at first stage by excision of the urethral plate, followed by covering the ventral shaft by skin flaps or inner preputial graft. The second stage (Thiersch -Duplay urethroplasty) was performed six months later. The de-epithelialized overlap flap (double breasting) technique was used to cover the neo-urethra in all cases, which was combined with a dartos scrotal flap to cover the proximal neourethra when indicated.
Results: The study included 17 boys with proximal hypospadias who underwent two-stage repair. Follow up period after second stage ranged between 6 and 30 months (mean 19.7; median 18.5). Most complications were related to distal/glanular disruptions whether partial or complete (5 cases). One case developed a penoscrotal fistula that was closed surgically. Another case (belonging to the group which used preputial graft in the 1st stage) presented 21 months after the second stage with urethral stricture (penoscrotal).
Conclusion: With the trend back to two-stage repairs for proximal hypospadias, applying the de-epithelialized double-breasting skin closure can offer a reliable second layer to support the neourethra along the penile shaft.
SMAD2/3 signaling in the uterine epithelium controls endometrial cell homeostasis and regeneration
Authors: Kriseman Maya , Tang Suni , Liao Zian , Jiang Peixin , Parks Sydney , Cope Dominique , Yuan Fei , Chen Fengju , Masand Ramya , Castro Patricia , Ittmann Michael , Creighton Chad , Tan Zhi , Monsivais Diana 
Published: September 2022

Abstract
The regenerative potential of the endometrium is attributed to endometrial stem cells; however, the signaling pathways controlling its regenerative potential remain obscure. In this study, genetic mouse models and endometrial organoids were used to demonstrate that SMAD2/3 signaling controls endometrial regeneration and differentiation. Mice with conditional deletion of SMAD2/3 in the uterine epithelium using Lactoferrin-iCre developed endometrial hyperplasia at 12-weeks and metastatic uterine tumors by 9-months of age. Mechanistic studies in endometrial organoids determined that genetic or pharmacological inhibition of SMAD2/3 signaling disrupted organoid morphology, increased the glandular and secretory cell markers, FOXA2 and MUC1, and altered the genome-wide distribution of SMAD4. Transcriptomic profiling of the organoids revealed elevated pathways involved in stem cell regeneration and differentiation such as the bone morphogenetic protein (BMP) and retinoic acid signaling (RA) pathways. Therefore, TGFβ family signaling via SMAD2/3 controls signaling networks which are integral for endometrial cell regeneration and differentiation.
Knock-down of Annexin A10 in trigeminal ganglion attenuates trigeminal neuropathic pain in mice
Authors: Miao Xiu Hua , jiang Yi , Zhang Hao , Zhou Ping , Ju Fei , Chen Quan , Li Liu , Zhou You Lang , Zhou Yuan 
Published: September 2022

Abstract
Trigeminal neuropathic pain (TNP) is an intense chronic orofacial pain syndrome, which the pathogenesis and treatment of it are still limited (Cruccu et al. 2020; Yadav et al. 2017). We induced TNP from adult male mice via partial infraorbital nerve ligation (pIONL)(Xu et al. 2008). The upregulated genes were screened in the trigeminal ganglion (TG) 7 days after pIONL and found that Annexin A10 (Anxa10) mRNA was up-regulated by up to 19-fold. PIONL induced persistent upregulation of Anxa10 mRNA and protein in trigeminal ganglion (TG). In addition, Anxa10 colocalized with the astrocyte marker glial fibrillary acidic protein (GFAP), the neuronal marker TUJ1 and with the microglial marker IB4. To knock-down of Anxa10 expression, lentivirus containing Anxa10-shRNA (LV-Anxa10-shRNA) was microinjected into TG, and successful infection of the lentivirus was verified by immunofluorescence. After inhibiting Anxa10, the mechanical pain threshold of pIONL mice decreased accompanied decreasing of TNF-α and IL-1β. Also, whole-cell patch-clamp recording showed that knock-down of Anxa10 suppressed nerve injury-induced hyperexcitation of TG neurons. In conclusion, Anxa10 is participated in the maintenance of trigeminal neuropathic pain, and we try to explore more about trigeminal neuropathic pain in the future.
Inhibition of the TRIM24 bromodomain reactivates latent HIV-1
Authors: Horvath Riley M. , Brumme Zabrina L. , Sadowski Ivan 
Published: September 2022

Abstract
Expression of the HIV-1 genome by RNA Polymerase II is regulated at multiple steps, as are most cellular genes, including recruitment of general transcription factors and control of transcriptional elongation from the core promoter. We discovered that tripartite motif protein TRIM24 is recruited to the HIV-1 Long Terminal Repeat (LTR) by interaction with TFII-I and causes transcriptional elongation by stimulating association of PTEF-b/ CDK9. Because TRIM24 is required for stimulation of transcription from the HIV-1 LTR, we were surprised to find that IACS-9571, a specific inhibitor of the TRIM24 C-terminal bromodomain, induces HIV-1 provirus expression in otherwise untreated cells. IACS-9571 reactivates HIV-1 in T cell lines bearing multiple different provirus models of HIV-1 latency. Additionally, treatment with this TRIM24 bromodomain inhibitor encourages productive HIV-1 expression in newly infected cells and inhibits formation of immediate latent repressed provirus. IACS-9571 synergizes with PMA, ionomycin, TNF-α, PEP005, and JQ1 to activate HIV-1 expression. Furthermore, co-treatment of CD4+ T cells from individuals with HIV-1 on antiretroviral therapy (ART) with PEP005 and IACS-9571 caused robust provirus expression. Notably, IACS-9571 did not cause global activation of T cells; rather, it inhibited induction of IL2 and CD69 expression in human PBMCs and Jurkat T cells treated with PEP005 or PMA. These observations indicate the TRIM24 bromodomain inhibitor IACS-9571 represents a novel HIV-1 latency reversing agent (LRA), and unlike other compounds with this activity, causes partial suppression of T cell activation while inducing expression of latent provirus.
Environmentally-friendly synthesis of copper(I)-Tricine complex intercalated layered double hydroxide coated magnetite nanocomposites and its application in oxidative esterification by using ultrasonic irradiation
Authors: Pazoki Farzane , Bagheri Sepideh , Yazdani Elahe , Mohsenzadeh Fatemeh , Heydari Akbar 
Published: September 2022

Abstract
In this work, an approach described to successful intercalation of copper(I)-Tricine complex into layered double hydroxide (LDH) coated on magnetite nanocomposites by ultrasonic methods. The activity of this nanocatalyst was investigated for oxidative esterification of arylaldehydes under ultrasonic irradiation. The oxidative esterification reaction was performed in environmentally friendly condition, high yield, short reaction times and simple method with highly efficient catalyst system. In addition, this catalyst can be removed from the reaction medium simply by use of an external magnet.
Phenotypic characterization of single CD4+ T cells harboring genetically intact and inducible HIV genomes
Authors: Dufour Caroline , Richard Corentin , Pardons Marion , Massanella Marta , Ackaoui Antoine , Murrell Ben , Routy Bertrand , Thomas Réjean , Routy Jean-Pierre , Fromentin Remi , Chomont Nicolas 
Published: September 2022

Abstract
The phenotype of the rare HIV-infected cells persisting during ART remains elusive. We developed a single-cell approach that combines the phenotypic analysis of HIV-infected cells with near full-length sequencing of their associated proviruses. Individual cells carrying clonally expanded identical proviruses displayed very diverse phenotypes, indicating that cellular proliferation contributes to the phenotypic diversification of the HIV reservoir. Unlike most viral genomes persisting on ART, inducible and translation-competent proviruses rarely presented large deletions but were enriched in defects in the Ψ locus. Interestingly, the few cells harboring genetically intact and inducible viral genomes expressed higher levels of the integrin VLA-4 compared to uninfected cells or cells with defective proviruses. Viral outgrowth assay confirmed that memory CD4+ T cells expressing high levels of VLA-4 were highly enriched in replication-competent HIV (27-fold enrichment). We conclude that although clonal expansions diversify the phenotype of HIV reservoir cells, CD4+ T cells harboring replication-competent HIV retain VLA-4 expression.
Short Sleep Duration Associated with the Incidence of Cardio-Cerebral Vascular Disease: a Prospective Cohort Study in Shanghai, China
Authors: Ke Juzhong , Liu Xiaolin , Ruan Xiaonan , Wu Kang , Qiu Hua , Wang Xiaonan , Li Zhitao , Lin Tao 
Published: September 2022

Abstract
Importance: Sleep duration plays an important role in predicting CCVD incidence, and have implications for reducing the burden of CCVD. However, the association between sleep duration and predicted cardio-cerebral vascular diseases (CCVD)risk remains to be fully understood.
Objective: To investigate the effects of sleep duration on the development of CCVD among Chinese community residents.
Design: A prospective cohort study. The baseline survey was conducted from January 2013 to July 2013. The cohort has been followed until December 31, 2016 using a combination of in-person interviews and record linkages with the vital registry of Pudong New Area, Shanghai, China.
Subjects: A total of 9247 Chinese community residents were initially enrolled in the cohort. Of those, 6476 underwent the follow-up examination.
Exposure: Self-reported sleep duration and sleep quality were obtained via the questionnaire. Sleep duration was divided into five categories: ≤5, 6, 7, 8, or≥9 hours per day.
Main Outcome(s) and Measure(s): CCVD, Coronary heart disease (CHD) and Stroke occurrence, Hazard ratios (HRs) and 95% confidence intervals (95% CIs) were calculated using Cox proportional hazards models.
Results: During a median follow-up of 3.00 years (IQR 2.83-3.08), we observed 393 participants have had incident CCVD events, of whom 216 had CHDs, 148 had strokes, and 29 had both. After adjustment for relevant confounders, short sleepers (≤5h) had 70% higher risk of total CCVD incidence (HR: 1.70; 95%CI: 1.24-2.34), 66% higher risk of CHD incidence (HR: 1.66; 95%CI: 1.11-2.47), and 65% higher risk of stroke incidence (HR: 1.65; 95%CI: 1.03-2.65) in contrast to the reference group (7h). Some of these U-shaped relationships varied by age, and were more pronounced in individuals aged <65 years. Individuals who slept ≤5h per day with baseline hypertension had the highest risk of CCVD incidence (HR: 4.41, 95%CI 2.76-7.04), CHD incidence (HR: 2.52, 95%CI 1.43-4.44), and stroke incidence (HR: 3.72, 95%CI 1.66-8.34), compared with those sleep 7h and without baseline hypertension.
Conclusions: Short sleep duration is independently associated with greater incidence of CCVD, CHD and stroke.
Comparative analysis of clinical treatment of HIV positive and HIV negative bladder cancer patients
Authors: Yu Zhang Yu , Xiaolin Su Xiaolin , Xuyu Li Xuyu , Wenrui Xue Wenrui , Xin Wang Xin , Xudong Wang Xudong , Pengfei Yuan Pengfei , Zhixing Han Zhixing , Haijian Zhang Haijian , Yurun Liang Yurun , Yi Cui Yi , Qingjun Liu Qingjun , Shiqi Ji Shiqi 
Published: September 2022

Abstract
Objective: To provide clinical reference for the prevention and treatment of HIV positive bladder cancer by comparing and analyzing the basic information, laboratory examination, treatment and follow-up of HIV positive and non-HIV infected bladder cancer patients.
Methods: This study collected 57 bladder cancer patients with complete data who were admitted to Beijing Ditan Hospital and Beijing You 'an Hospital from 2013 to 2021, including 14 cases in the HIV positive group and 43 cases in the HIV negative group. A retrospective analysis was conducted on the HIV infection route of HIV positive patients and whether antiviral treatment was regular. The viral load and the number of CD4+T lymphocytes before surgery were compared. The preoperative laboratory examination, pathological grade, treatment methods, 3-month recurrence and long-term follow-up of bladder cancer patients in the two groups were compared.
Results: In this study, the average age of onset in the HIV positive group was (48.93±13.83) years old, while the average age of onset in the non-HIV group was (62.05±13.38) years old, and the difference was statistically significant (P<0.01). There were no statistically significant differences in the values of white blood cells, platelets, creatinine and albumin in preoperative laboratory tests between HIV group and non-HIV group (P>0.05), but there were statistically significant differences in red blood cell values between the two groups (P<0.05).There was no difference in pathological grade of bladder cancer between the two groups. The recurrence rate was 21.43% in HIV-positive patients and 23.26% in non-HIV patients at 3 months after surgery (P>0.05). The median long-term follow-up was 40 months (8-78 months). The survival rate of the two groups was HIV VS non-HIV (71.42% VS 93.02%) (P>0.05).
Conclusions: The clinical characteristics of HIV-positive bladder cancer patients are similar to that of the general population, and HIV positive bladder cancer patients also follow the guidelines for the general population in terms of treatment measures. The early age of HIV positive bladder cancer patients remains to be further studied.
Endogenous fluctuations in cortical state selectively enhance different modes of sensory processing
Authors: Parajuli Arun , Gutnisky Diego , Tandon Nitin , Dragoi Valentin 
Published: September 2022

Abstract
The degree of synchronized fluctuations in neocortical network activity can vary widely during alertness. One influential idea that has emerged over the past few decades is that perceptual decisions are more accurate when the state of population activity is desynchronized. This suggests that optimal task performance may occur during a particular cortical state – the desynchronized state. Here we show that, contrary to this view, cortical state can both facilitate and suppress perceptual performance in a task-dependent manner. We performed electrical recordings from surface-implanted grid electrodes in the temporal lobe while human subjects completed two perceptual tasks. We found that when local population activity is in a synchronized state, network and perceptual performance are enhanced in a detection task and impaired in a discrimination task, but these modulatory effects are reversed when population activity is desynchronized. These findings indicate that the brain has adapted to take advantage of endogenous fluctuations in cortical state to selectively enhance different modes of sensory processing during perception in a state-dependent manner.
Reducing COVID-19 Vaccine Fatigue: Results of Two Conjoint Experiments
Authors: Stamm Tanja , Partheymueller Julia , Mosor Erika , Ritschl Valentin , Kritzinger Sylvia , Alunno Alessia , Eberl Jakob-Moritz 
Published: September 2022

Abstract
COVID-19 vaccine fatigue is a major challenge in keeping the immunity in the general population up to date. Yet, not enough is known about how this problem can be overcome. We assessed vaccine acceptance in future scenarios in two conjoint experiments, manipulating factors such as new vaccines, communication, costs/incentives, and legal rules. The experiments were embedded in an online survey (N= 6,357 participants) conducted simultaneously in two European countries (Austria and Italy). The results show that adapted vaccines, their cost-free provision and expert consensus could help to counteract vaccine fatigue. To some extent, also positive incentives, celebrity endorsements, and knowledge about Long COVID may motivate citizens to get the vaccination. Motivational appeals mainly affected secondary outcomes such as the evaluation of vaccination campaigns. As the effect sizes of treatments were modest overall, vaccination campaigns should focus on mobilizing those with a general willingness to get vaccinated.
Constraint on regional land surface air temperature projections in CMIP6 multi-model ensemble
Authors: Zhang Jie , Wu Tongwen , Li Laurent , Furtado Kalli , Xie Chengjun , Zheng Mengzhe , Zhao He , Zhou Yumeng 
Published: September 2022

Abstract
The reliability of the near-land-surface air temperature (LSAT) projections from the state-of-the-art climate-system models that participated in the Coupled Model Intercomparison Project phase six (CMIP6) is debatable, particularly on regional scales. Here we introduce a new method of constructing a constrained multi-model-ensemble (CMME), based on rejecting models that fail to reproduce observed LSAT trends. We use the CMME to constrain future LSAT projections under the Shared Socioeconomic Pathways 5-8.5 (SSP5-8.5) in the 21st century; this scenario represents the high end of the range of future pathway uncertainty. In comparison with the “raw” (unconstrained) CMIP6 multi-model ensemble (MME) mean, the impact of the observation-based constraint is less than 0.1 oC/100years at global scale over the 21st century. However, the regional results show a wider range of positive and negative adjustments from -1.0oC/100years to 1 oC/100years. The ideal 1pctCO2 experiment suggests that the response of LSAT to carbon dioxide (CO2) forcing on regional scales is responsible for the MME biases in historical period, indicating the higher reliability of CMME in the 21st century projections. The advantage of CMME is that it goes beyond the idea of “model democracy” assumed in MME. The unconstrained CMIP6 MME may be overestimating the risks of future warming over North America, Europe, and North Africa, but underestimating the risks over Asia.
Does vitamin D deficiency really increase the risk of post-surgical hypoparathyroidism?
Authors: Vilar José Alberto , Ramírez Joaquín Gómez , Brabyn Philip , Puerta Ana , Gonzalez Alberto , Cebrián José María 
Published: September 2022

Abstract
BACKGROUND: Postoperative hypoparathyroidism is the most frequent complication after total thyroidectomy. The identification of preoperative predictors could be helpful to identify patients at risk. The aim of this study is to determine if preoperative vitamin D levels are related to transient, protracted, and permanent hypoparathyroidism.
METHOD: A prospective, observational study that includes 100 patients who underwent total thyroidectomy.
RESULTS: Transient hypoparathyroidism was present in 42% of patients, 11% developed protracted hypoparathyroidism and 5% permanent hypoparathyroidism.
The median preoperative Vitamin D levels were higher in patients who developed transient hypoparathyroidism than in patients without this complication (24 ng/mL [RIQ 13-31] vs. 17 ng/mL [RIQ 10-24]; p=0.024). Patients with preoperative vitamin D levels below 20 ng/mL had a lower percentage of transient hypoparathyroidism (31.4% vs. 53.1%; p=0.028). The prevalence of protracted and permanent hypoparathyroidism in both groups was similar. Patients with preoperative vitamin D levels lower than 20 pg/mL had higher median PTH levels 24 hours after surgery, (37.7 ± 28.2 pg/ml vs. 23.6 ± 18.6 pg/ml; p=0.037), and suffered a lower postoperative PTH decline (46.2 ± 35.4 % vs. 61 ± 29 %; p=0.026).
CONCLUSIONS:Patients with vitamin D deficiency had a lower transient hypoparathyroidism rate, higher median PTH levels 24 hours after surgeryand a lower postoperative PTH decline. We found no association between preoperative vitamin D and the development of protracted or permanent hypoparathyroidism.
The time course of social and non-social implicit Sense of Agency
Authors: Silver Crystal A , Tatler Benjamin W , Chakravarthi Ramakrishna , Timmermans Bert 
Published: September 2022

Abstract
Sense of Agency (SoA) is the responsibility felt over our actions and their effects. Social Agency is when SoA occurs in a social context. Whether and how SoA and Social Agency differ remains largely unknown. As non-social interaction is fundamentally governed by the laws of physics and material properties, action-effect contiguity is expected. This is not so when interacting with conspecifics, who we know act under their own volition, at a time of their choosing. Therefore, temporal contingency is a characteristic where social and non-social agency may differ. In three experiments, this exploratory study directly compared the time course of implicit SoA in social and non-social cooperative interactions by varying action-effect intervals. Participants were told they were a) interacting via live webcams with another person (social condition), b) interacting with pre-recorded videos (non-social condition) or c) observing two pre-recorded videos (control condition; Experiment 3). Results across all experiments showed greater implicit agency effects for social compared to non-social conditions through Temporal Binding (i.e., the perceived compression of action-effect interval duration; TB), and this to a proportionally comparable degree across all action-effect intervals. Further, in Experiments 1 and 2, there was consistent social TB throughout, whereas non-social TB decreased during the second half. In Experiment 3, the non-social condition did not differ from control, whereas the social condition did, exhibiting enhanced binding. These findings indicate that implicit Social Agency is enhanced, compared to non-social agency, in cooperative interaction. Social Agency also exhibits TB effects at shorter action-effect intervals than non-social agency.