bluuebunny/crossref_metadata_2025_split huggingface dataset:
Critical illness associated new onset atrial fibrillation: subsequent atrial fibrillation diagnoses and other adverse outcomes
Authors: Lancini Daniel , Tan Wei Lian , Guppy-Coles Kristyan , Boots Robert , Prasad Sandhir , Atherton John , Martin Paul 
Published: October 2022

AbstractAimsAmongst patients with critical illness associated new onset AF (CI-NOAF), the risk of subsequent atrial fibrillation (AF) diagnoses and other adverse outcomes is unknown, and the role for long-term anticoagulation is unclear. This study sought to determine the factors associated with subsequent AF diagnoses and other adverse outcomes in this cohort.Methods and resultsAdmissions to a tertiary general intensive care unit (ICU) between December 2015 and September 2018 were screened for AF episodes through hourly analysis of continuous ECG monitoring. Patients with a prior history of AF were excluded. AF burden was defined as the percentage of monitored ICU hours in AF. The primary endpoint was subsequent AF diagnoses, as collated from the statewide electronic medical records. Secondary endpoints included mortality, embolic events, MACE and subsequent anticoagulation.ResultsOf 7030 admissions with 509 303 h of monitoring data, 309 patients with CI-NOAF were identified, and 235 survived to discharge. Subsequent AF diagnoses were identified in 75 (31.9%) patients after a median of 413 days. Increased AF burden had the strongest independent association with AF recurrence (OR = 15.03, P = 0.002), followed by increased left atrial area (OR = 1.12, P = 0.01). Only 128 (54.5%) patients had their AF diagnosis acknowledged at ICU discharge, and 50 (21.3%) received anticoagulation at hospital discharge.ConclusionCI-NOAF is often under-recognized, and subsequent AF diagnoses are common post-discharge. AF burden during ICU admission has a strong independent association with subsequent AF diagnoses. Left atrial size is also independently associated with subsequent AF.
Ventricular arrhythmias in arrhythmic mitral valve syndrome—a prospective continuous long-term cardiac monitoring study
Authors: Aabel Eivind W , Chivulescu Monica , Lie Øyvind H , Hopp Einar , Gjertsen Erik , Ribe Margareth , Helle-Valle Thomas M , Edvardsen Thor , Hegbom Finn , Dejgaard Lars A , Haugaa Kristina H 
Published: October 2022

AbstractAimsArrhythmic mitral valve syndrome is linked to life-threatening ventricular arrhythmias. The incidence, morphology and methods for risk stratification are not well known. This prospective study aimed to describe the incidence and the morphology of ventricular arrhythmia and propose risk stratification in patients with arrhythmic mitral valve syndrome.MethodsArrhythmic mitral valve syndrome patients were monitored for ventricular tachyarrhythmias by implantable loop recorders (ILR) and secondary preventive implantable cardioverter-defibrillators (ICD). Severe ventricular arrhythmias included ventricular fibrillation, appropriate or aborted ICD therapy, sustained ventricular tachycardia and non-sustained ventricular tachycardia with symptoms of hemodynamic instability.ResultsDuring 3.1 years of follow-up, severe ventricular arrhythmia was recorded in seven (12%) of 60 patients implanted with ILR [first event incidence rate 4% per person-year, 95% confidence interval (CI) 2–9] and in four (20%) of 20 patients with ICD (re-event incidence rate 8% per person-year, 95% CI 3–21). In the ILR group, severe ventricular arrhythmia was associated with frequent premature ventricular complexes, more non-sustained ventricular tachycardias, greater left ventricular diameter and greater posterolateral mitral annular disjunction distance (all P &lt; 0.02).ConclusionsThe yearly incidence of ventricular arrhythmia was high in arrhythmic mitral valve syndrome patients without previous severe arrhythmias using continuous heart rhythm monitoring. The incidence was even higher in patients with secondary preventive ICD. Frequent premature ventricular complexes, non-sustained ventricular tachycardias, greater left ventricular diameter and greater posterolateral mitral annular disjunction distance were predictors of first severe arrhythmic event.
Resequencing of sweetpotato germplasm resources reveals key loci associated with multiple agronomic traits
Authors: Xiao Shizhuo , Dai Xibin , Zhao Lingxiao , Zhou Zhilin , Zhao Lukuan , Xu Pan , Gao Bingqian , Zhang An , Zhao Donglan , Yuan Rui , Wang Yao , Wang Jie , Li Qinglian , Cao Qinghe 
Published: October 2022

Abstract
Sweetpotato is an important crop that exhibits hexaploidy and high heterozygosity, which limits gene mining for important agronomic traits. Here, 314 sweetpotato germplasm resources were deeply resequenced, and 4 599 509 SNPs and 846 654 InDels were generated, among which 196 124 SNPs were nonsynonymous and 9690 InDels were frameshifted. Based on the Indels, genome-wide marker primers were designed, and 3219 of 40 366 primer pairs were selected to construct the core InDel marker set. The molecular ID of 104 sweetpotato samples verified the availability of these primers. The sweetpotato population structures were then assessed through multiple approaches using SNPs, and diverse approaches demonstrated that population stratification was not obvious for most Chinese germplasm resources. As many as 20 important agronomic traits were evaluated, and a genome-wide association study was conducted on these traits. A total of 19 high-confidence loci were detected in both models. These loci included several candidate genes, such as IbMYB1, IbZEP1, and IbYABBY1, which might be involved in anthocyanin metabolism, carotenoid metabolism, and leaf morphogenesis, respectively. Among them, IbZEP1 and IbYABBY1 were first reported in sweetpotato. The variants in the promoter and the expression levels of IbZEP1 were significantly correlated with flesh color (orange or not orange) in sweetpotato. The expression levels of IbYABBY1 were also correlated with leaf shape. These results will assist in genetic and breeding studies in sweetpotato.
Spectrophotometric Quantitative Analysis of Aspirin and Vonoprazan Fumarate in Recently Approved Fixed-Dose Combination Tablets Using Ratio Spectra Manipulating Tools
Authors: Abdelazim Ahmed H , Abdel-Fattah Ashraf , Osman Ayman O E , Abdel-Kareem Rady F , Ramzy Sherif 
Published: October 2022

AbstractBackgroundLow-dose aspirin (ASP) is prescribed to millions of people around the world as a secondary preventative strategy for the majority of significant cardiovascular events; however, it carries a substantial risk of gastric ulcer and bleeding. Cabpirin® tablets, which include low-dose ASP and vonoprazan fumarate (VON), are approved in Japan for the treatment of acid-related diseases in patients who require a low dose of ASP but are at risk of ASP-associated gastric ulcers.ObjectiveThis paper describes the first published quantitative analytical approaches for the determination of ASP and VON.MethodThe normal ultraviolet absorption spectra of ASP and vonoprazan overlap significantly. The ratio spectra of the studied drugs were created and manipulated by ratio difference (RD) and first derivative of ratio spectra approaches. In the RD approach, the differences in the amplitude values between 229 and 283 nm enabled the quantitative analysis of ASP, and the differences in the amplitude values between 255 and 212 nm enabled the quantitative analysis of vonoprazan. In the first derivative of the ratio spectra approach, the created ratio spectra of each drug were transformed to the first-order derivative. ASP could be determined selectively at 237.40 nm without interference from vonoprazan. Moreover, vonoprazan could be determined selectively at 244 nm without interference from ASP.ResultsThe applied approaches were validated according to the ICH guideline, with good results. Linear correlations were obtained for ASP and vonoprazan over concentration ranges of 2–25 and 1–10 µg/mL, respectively.ConclusionsThe described methods were optimized, validated, and applied for determination of the studied drugs in the synthetic mixtures and in pharmaceutical tablets without interferences.HighlightsTwo spectrophotometric ratio spectra manipulating approaches were developed for the determination of the ASP and vonoprazan in their pharmaceutical combination tablets.
The Association Between Financial Toxicity and Treatment Regret in Men With Localized Prostate Cancer
Authors: Joyce Daniel D , Wallis Christopher J D , Huang Li-Ching , Hoffman Karen E , Zhao Zhiguo , Koyama Tatsuki , Goodman Michael , Hamilton Ann S , Wu Xiao-Cheng , Paddock Lisa E , Stroup Antoinette , Cooperberg Matthew R , Hashibe Mia , O’Neil Brock B , Kaplan Sherrie H , Greenfield Sheldon , Penson David F , Barocas Daniel A 
Published: October 2022

Abstract

Background
Financial toxicity is emerging as an important patient-centered outcome and is understudied in prostate cancer patients. We sought to understand the association between financial burden and treatment regret in men with localized prostate cancer to better evaluate the role of financial discussions in patient counseling.

Methods
Utilizing the Comparative Effectiveness Analysis of Surgery and Radiation dataset, we identified all men accrued between 2011 and 2012 who underwent surgery, radiation, or active surveillance for localized prostate cancer. Financial burden and treatment regret were assessed at 3- and 5-year follow-up. The association between financial burden and regret was assessed using multivariable longitudinal logistic regression controlling for demographic and disease characteristics, treatment, functional outcomes, and patient expectations.

Results
Of the 2924 eligible patients, regret and financial burden assessments for 3- and/or 5-year follow-up were available for 81% (n = 2359). After adjustment for relevant covariates, financial burden from “finances in general” was associated with treatment regret at 3 years (odds ratio [OR] = 2.47, 95% confidence interval [CI] = 1.33 to 4.57; P = .004); however, this association was no longer statistically significant at 5-year follow-up (OR = 1.19, 95% CI = 0.56 to 2.54; P = .7).

Conclusions
In this population-based sample of men with localized prostate cancer, we observed associations between financial burden and treatment regret. Our findings suggest indirect treatment costs, especially during the first 3 years after diagnosis, may impact patients more profoundly than direct costs and are important for inclusion in shared decision making.
The effect of modulation of gut microbiome profile on radiation-induced carcinogenesis and survival
Authors: Cook John A , Sowers Anastasia L , Choudhuri Rajani , Gadisetti Chandramouli , Edmondson Elijah F , Gohain Sangeeta , Krishna Murali C , Mitchell James B 
Published: October 2022

Abstract
Non-lethal doses of ionizing radiation (IR) delivered to humans because of terrorist events, nuclear accidents or radiotherapy can result in carcinogenesis. Means of protecting against carcinogenesis are lacking. We questioned the role of the gut microbiome in IR-induced carcinogenesis. The gut microbiome was modulated by administering broad spectrum antibiotics (Ab) in the drinking water. Mice were given Ab 3 weeks before and 3 weeks after 3 Gy total body irradiation (TBI) or for 6 weeks one month after TBI. Three weeks of Ab treatment resulted in a 98% reduction in total 16S rRNA counts for 4 out of 6 of the phylum groups detected. However, 3 more weeks of Ab treatment (6 weeks total) saw an expansion in the phylum groups Proteobacteria and Actinobacteria. The Ab treatment altered the bacteria diversity in the gut, and shortened the lifespan when Ab were administered before and after TBI. Mortality studies indicated that the adverse Ab lifespan effects were due to a decrease in the time in which solid tumors started to appear and not to any changes in hematopoietic or benign tumors. In contrast, when Ab were administered one month after TBI, lifespan was unchanged compared to the control TBI group. Use of broad-spectrum antibiotics to simulate the germ-free condition did not afford an advantage on carcinogenesis or lifespan.
Smoke promotes germination of peatland bryophyte spores
Authors: Yusup Shuayib , Sundberg Sebastian , Ooi Mark K J , Zhang Mingming , Sun Zhongqiu , Rydin Håkan , Wang Meng , Feng Lu , Chen Xu , Bu Zhao-Jun 
Published: October 2022

Abstract
Northern peatlands are globally important carbon stores. With increasing fire frequency, the re-establishment of bryophytes becomes crucial for their carbon sequestration. Smoke-responsive germination is a common trait of seeds in fire-prone ecosystems but has not been demonstrated in bryophytes. To investigate the potential role of smoke in post-fire peatland recovery, we tested the germination of spores of 15 bryophyte species after treatment with smoke-water. The smoke responsiveness of spores with different laboratory storage times and burial depths/age (3–200 years) was subsequently tested. Smoke increased the germination percentage for 10 of the species and the germination speed for four of these. Smoke responsiveness increased along the fire frequency gradient from open expanse to forest margin, consistent with the theory that this selects for the maintenance of fire-adapted traits. Smoke enhanced the germinability of 1-year but not 4-year laboratory-stored spores, and considerably increased the germinability of spores naturally buried in peat for up to ~200 years. The effect of fire may be overlooked in non-fire-prone ecosystems, such as those in which wetland bryophytes dominate. Our study reveals a mechanism by which an increase in fire frequency may lead to shifts in species dominance, which may affect long-term carbon sequestration in peatlands.
The jet apparent motion and central engine study of Fermi blazars
Authors: Xiao H B , Zhu J T , Fan J H , Pei Z Y , Luo Z J , Zhang S H 
Published: October 2022

ABSTRACT
The study of blazar jet has been performed for several decades via VLBI technique, while its generation and propagation stay unclear. In the present work, we compiled a sample of 407 VLBI detected Fermi blazars (VFBs) and studied the correlations between apparent velocity (${\rm log}\, \beta _{\rm app}$) and jet/accretion disc properties. We found a positive correlation between γ-ray luminosity (${\rm log}\, L_{\rm \gamma }$) and ${\rm log}\, \beta _{\rm app}$; the correlation suggests that the apparent motion of jet knot is related to the jet power. The correlations between ${\rm log}\, \beta ^{\rm max}_{\rm app}$ and the jet radiation power (${\rm log}\, L_{\rm rad}$), and between ${\rm log}\, \beta ^{\rm max}_{\rm app}$ and the jet extended region luminosity at 5 GHz (${\rm log}\, L_{\rm 5GHz}^{\rm ext}$), which is an indicator of jet kinetic power, reveal that the knots apparent motion is correlated with both jet radiation power and the kinetic power. But this indication is not held for flat-spectrum radio quasar (FSRQs) in terms of the correlation ${\rm log}\, L_{\rm 5GHz}^{\rm ext}\, versus \, {\rm log}\, \beta ^{\rm max}_{\rm app}$. Besides, ${\rm log}\, \beta ^{\rm max}_{\rm app}$ has a moderate correlation with accretion disc luminosity (${\rm log}\, L_{\rm Disk}$) and the normalized accretion disc luminosity ${\rm log}\, (L_{\rm Disk}/L_{\rm Edd})$, which may suggest both the power of accretion disc and the accretion rate are critical to generate knots and to accelerate them. In addition, we found the VFBs have larger average values of γ-ray luminosity (${\rm log}\, L_{\rm \gamma }$), γ-ray photon index (αph), and variability index (${\rm log}\, VI$) than the rest of Fermi blazars. Through Gaussian mixture models method, we generated a criteria, ${\rm log}\, L_{\rm \gamma } \gt 45.40$, αph &gt; 2.24, and ${\rm log}\, VI \gt 1.71$ to find VFB candidates, selected 228 VFB candidates from the rest of Fermi blazar.
Cool interstellar medium as an evolutionary tracer in ALMA-observed local dusty early-type galaxies
Authors: Glass David H W , Sansom Anne E , Davis Timothy A , Popescu Cristina C 
Published: October 2022

ABSTRACT
The content and distribution of cool interstellar medium (&lt;30 K) can indicate the evolutionary mechanisms that transform late-type to early-type galaxies (ETGs). To investigate this, ALMA observations of 12CO[2-1] line emission were obtained for five dusty ETGs from a complete sample in low-density environments. Four of the ETGs have massive (∼109 M⊙), extended molecular gas reservoirs with effective radii ∼3–5 kpc. This work provides a kinematic and structural analysis of these observations, to explore possible evolutionary mechanisms. Axisymmetric or bisymmetric kinematic models were fitted to observations of molecular gas discs, to quantify the dominant structures present and highlight additional structures or asymmetries. Integral field unit observations of these ETGs were also examined where available. Two of the ETGs, GAMA64646 and 622305, appear to have undergone tidal disturbance leading to molecular gas discs and/or star-forming inner rings. GAMA272990 may have undergone a merger, leading to an elliptical galaxy with an embedded star-forming molecular gas disc. GAMA622429 has probably undergone a minor merger, indicated by asymmetry in molecular gas distribution and disturbance in optical images. The remaining ETG, GAMA177186, was affected by source confusion from an offset source which could be a high-mass dust- and gas-rich object at high redshift. Overall, it appears that a high proportion of dusty ETGs in low-density environments have massive, extended molecular gas reservoirs, and have undergone some kind of interaction as part of their recent evolution. Secular evolution can then (re-)transform the ETGs from star-forming to passive galaxies.
Occupational rhinitis caused by hypersensitivity to black pepper
Authors: Perić Aleksandar , Sotirović Jelena , Jovančević Ljiljana , Medić Sonja Peričević 
Published: October 2022

Summary
Black pepper (Piper nigrum) rarely leads to allergic inflammation of the nasal mucosa. This is a presentation of a 52-year-old female worker exposed to black pepper dust for 10 years suffering from allergic rhinitis and chronic rhinosinusitis. She complained of nasal obstruction, rhinorrhoea, and a weakened sense of smell. Clinical examination showed the bilateral presence of polypoid lesions arising from the middle turbinate. After surgery, histopathological examination confirmed the diagnosis of inflammatory nasal polyps. Duration of exposure to black pepper and serum concentration of specific immunoglobulin E antibodies indicating work-related exposure would support a causal link between exposure to these factors and the development of chronic inflammation in the nasal mucosa. Inflammatory nasal polyps may be noted in the nasal cavity in workers exposed to black pepper dust. The absence of exposure to black pepper resulted in no detectable circulating antibodies one year after the change of workplace.
Chronic Use of Antipsychotics in Schizophrenia: Are We Asking the Right Question?
Authors: Rubio Jose M , Perez-Rodriguez Mercedes 
Published: October 2022

Abstract
There is an ongoing debate about the potential risks and benefits of long-term antipsychotic treatment in schizophrenia. The data for and against the chronic use of these medicines is mostly indirect, either from observational studies potentially exposed to reverse causation bias or randomized controlled studies that do not cover beyond 2–3 years. We propose that perseverating on the question of what positive or negative outcomes are causally associated with chronic antipsychotic treatment may not lead to better answers than the limited ones that we have, given the limited feasibility of more conclusive studies. Rather, we argue that addressing the research question of the risks and benefits of antipsychotic discontinuation from a perspective of personalized medicine, can be more productive and meaningful to people living with schizophrenia. To this end, research that can quantify the risk of relapse after treatment continuation for a given individual should be prioritized. We make the case that clinically feasible neuroimaging biomarkers have demonstrated promise in related paradigms, and that could be offering a way past this long debate on the risks and benefits of chronic antipsychotic use.
Early CRP Trends in Childhood Osteomyelitis Predict Complicated Disease
Authors: Hunter Sarah , Baker Joseph F. 
Published: October 2022

Background:
Acute hematogenous osteomyelitis (AHO) remains a cause of severe illness among children. Contemporary research aims to identify predictors of acute and chronic complications. Trends in C-reactive protein (CRP) after treatment initiation may predict disease course. We have sought to identify factors associated with acute and chronic complications in the New Zealand population.

Methods:
A retrospective review of all patients younger than16 years with presumed AHO presenting to a tertiary referral centre between 2008 and 2018 was performed. Multivariate was analysis used to identify factors associated with an acute or chronic complication. An “acute” complication was defined as the need for 2 or more surgical procedures, a hospital stays longer than 14 days, or recurrence despite intravenous antibiotics. A “chronic” complication was defined as growth or limb length discrepancy, avascular necrosis, chronic osteomyelitis, pathologic fracture, frozen joint, or dislocation.

Results:
One hundred fifty-one cases met the inclusion criteria. The median age was 8 years (69.5% male). Within this cohort, 53 (34%) experienced an acute complication and 18 (12%) a chronic complication. Regression analysis showed that contiguous disease, delayed presentation, and failure to reduce CRP by 50% at day 4/5 predicted an acutely complicated disease course. Chronic complication was predicted by the need for surgical management and failed CRP reduction by 50% at day 4/5.

Conclusions:
CRP trends over 96 hours after the commencement of treatment differentiate patients with AHO likely to experience severe disease.

Level of Evidence:
Level II, retrospective study