bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Systematic Review of Arts-Based Interventions Delivered to Children and Young People in Nature or Outdoor Spaces: Impact on Nature Connectedness, Health and Wellbeing
Authors: Moula Zoe , Palmer Karen , Walshe Nicola 
Published: March 2022

BackgroundThe time that children and young people spend in nature and outdoor spaces has decreased significantly over the past 30 years. This was exacerbated with a further 60% decline post-COVID-19. Research demonstrating that natural environments have a positive impact on health and wellbeing has led to prescription of nature-based health interventions and green prescribing, although evidence for its use is predominantly limited to adults. Growing evidence also shows the impact of arts on all aspects of health and wellbeing. However, what has received scant attention in literature is the interconnection between the two: arts and nature.AimsThis review synthesizes the literature surrounding the interconnectedness between arts and nature, and their impact on the health and wellbeing of children and young people.MethodsEight major electronic databases were systematically searched, while hand-searching included 20 journals, six books, and contact with experts. The review was conducted using the Cochrane handbook for systematic reviews, PRISMA guidelines and TIDieR template. All stages were conducted independently by two researchers and the protocol was published on PROSPERO (Registration no.: CRD42021286574).ResultsAlthough 9,314 records were identified, only 11 records were included as most studies focused either on arts or nature, but not both. Studies were conducted in United Kingdom, United States, Ireland, Australia, and Hong Kong, in a range of spaces such as forests, woodlands, beaches, parks, fields, gardens, and school playgrounds. The review encompasses data from 602 participants in total.DiscussionArts-in-nature offered an inclusive medium to engage all children and young people, especially those who might otherwise remain disinterested about environmental issues and disengaged with educational programs. Further, arts-in-nature provided stimuli to increase nature connectivity, understand environmental issues and explore ways to prevent environmental disasters. This led to higher environmental awareness and pro-environmental behaviors, and potential decrease in eco-anxiety.ConclusionAlthough the quality of qualitative studies was high, the quality of quantitative studies was low or unclear, thus quantitative evidence is still at its infancy. Implications for research, policy, and practice are discussed, such as methods and activities to strengthen future interventions. Scaling-up existing interventions may lead to wider recognition and inclusion of arts-in-nature in future health guidelines, including green prescribing.
Psychometric Properties of the Interpersonal Needs Questionnaire-15 in Spanish Adolescents
Authors: Pérez Rodríguez Sandra , García-Alandete Joaquín , Gallego Hernández de Tejada Blanca , Guillén Verónica , Marco Jose Heliodoro 
Published: March 2022

BackgroundThwarted Belongingness (TB) and Perceived Burdensomeness (PB) are considered risk factors of suicide behavior in the Interpersonal Theory of Suicide and constitute the main factors of the Interpersonal Needs Questionnaire—INQ.AimsThe present study analyzes the internal consistency, construct validity, and invariance across sex and age of the INQ-15, which comprises two subscales, in a sample of Spanish community adolescents.MethodsParticipants were 1,536 adolescents from 12 to 19 years old. The INQ-15, the total number of non-suicidal self-injuries (NSSI), the Hopelessness Scale, and the Purpose in Life Test-Adolescents (PIL-A) were used.ResultsThe INQ-15 showed good internal consistency for TB (ω¯ = 0.88) and PB (ω¯ = 0.78) subscales and construct and concurrent/discriminant validity in the whole sample. Both the PB and TB subscales showed a good fit {SBχ2(9) = 6.448, p = 0.694, CFI = 1.000, RMSEA = 0.000 [90% CI (0.000, 0.022)] and SBχ2(27) = 248.973, p = 0.000, CFI = 0.922, RMSEA = 0.073 [90% CI (0.065, 0.082)]}, respectively. Regarding the invariance analyses, we found (1) non-invariance in the PB subscale across sex groups and metric, scalar, and stric invariance across age groups, and (2) that it was not possible to perform the invariance analysis for the TB subscale across both sex and age because the fit was not adequate for both boys and 12–15 years old groups. Positive and significant relationships were found between the INQ-15 subscales and hopelessness and NSSI frequency, and negative and significant correlations with meaning in life.ConclusionsThe INQ-15 is a valid instrument for assessing TB and PB in Spanish adolescents. Future studies should analyze the invariance of this instrument in adolescents across sex and age.
Longitudinal Impact of the COVID-19 Pandemic on Older Adults' Wellbeing
Authors: López Javier , Pérez-Rojo Gema , Noriega Cristina , Martínez-Huertas Jose Angel , Velasco Cristina 
Published: March 2022

BackgroundThe COVID-19 pandemic is a major stressful life event. This pandemic is causing significant changes in older adults' daily life affecting their physical and mental health. Psychological wellbeing is a protective variable when facing adverse circumstances, like the COVID-19 pandemic. This study analyzes the impact of COVID-19 on older adults' psychological wellbeing (personal growth and purpose in life) over time.Materials and MethodsOne hundred ninety-two people over 60 years old participated in a longitudinal study. Data were collected in three time points: during the lockdown on March 2020, when the lockdown finished (4 months after baseline), and during the third wave (10 months after baseline). We used latent growth curve models to assess the linear longitudinal trajectories of psychological wellbeing.ResultsOlder adults did not show worse psychological wellbeing over time. Age has a positive impact on purpose in life. Furthermore, being a male, worrying about adverse effects of COVID-19, family functioning, resilience, personal growth, and acceptance associated with purpose in life.DiscussionThese results suggest that despite the difficult circumstances experienced during the COVID-19 pandemic, older adults have used protective variables for their psychological wellbeing.
Well-Being at Home During Forced Quarantine Amid the COVID-19 Pandemic
Authors: Krajewska-Kułak Elzbieta , Kułak-Bejda Agnieszka , Kułak Wojciech , Bejda Grzegorz , Łukaszuk Cecylia , Waszkiewicz Napoleon , Cybulski Mateusz , Guzowski Andrzej , Fiłon Joanna , Aniśko Paulina , Popławska Magda 
Published: March 2022

IntroductionPeople recently or currently in forced quarantine or isolation at home have shown high levels of depression and symptoms of generalized anxiety.Aim of the StudyTo assess the impact of the COVID-19 pandemic on certain aspects of people's day-to-day functioning.Materials and MethodsThe study involved using an online diagnostic survey including a proprietary questionnaire, the DASS 21, and the Liebowitz Social Anxiety Scale.ResultsInformation about the pandemic in Poland and around the world was systematically obtained by 48.8 and 27.4% of respondents, respectively (N = 1,312). Whereas, 75.6% of respondents declared having knowledge about the number of infected people in Poland, only 28.7% declared having such knowledge about infections worldwide. Most often, respondents had obtained information online (65.9%). According to 45.7% of respondents, infection with COVID-19 is a major threat, and not enough has been done to reduce its spread in Poland (66.7%) or worldwide (56.1%). Respondents considered social distancing (68.3%), quarantining people arriving from abroad (63.4%), and wearing protective masks and/or gloves (60.4%) to be the most effective actions for combatting the pandemic. Most often, in compulsory quarantines, respondents surfed the Internet (48.8%) and experienced a lack of energy or fatigue (40.2%) and anxiety (54.9%). The severity of anxiety (mean = 4.6 points), stress (7.5 points), and depression (7.3 points) were within normal ranges, and the respondents could generally be included in the group showing mildly severe social phobia (57.9 points).ConclusionsMost respondents considered infection with COVID-19 to be a major threat and feared another quarantine. During quarantine, respondents most often experienced fatigue, a lack of energy, nervousness, anxiety, anger, and sadness. Despite demonstrating anxiety, stress, and depression with severity in the normal range, respondents showed no statistically significant correlation between severity and age, gender, place of residence, or level of education. Although they also showed mildly severe social phobia, only gender, not age, place of residence, or level of education, showed a statistically significant correlation with its severity.
Association Between Antidepressant Efficacy and Interactions of Three Core Depression-Related Brain Networks in Major Depressive Disorder
Authors: Wang Qiang , Tian Shui , Zhao Peng , Cao Qiuyun , Lu Qing , Yao Zhijian 
Published: March 2022

BackgroundThe central executive network (CEN), salience network (SN), and default mode network (DMN) are the three most studied depression-related brain networks. Many studies have shown that they are related to depression symptoms and treatment effects. However, few studies have related these three networks and their activity frequency bands to depressive symptoms and treatment efficacy.MethodsSixty-six medication-free patients with major depressive disorder (MDD) were enrolled. Magnetoencephalography (MEG) was administered at baseline to calculate imaging indicators such as the power and functional connectivity (FC) of each brain network. The Hamilton Rating Score for Depression (HRSD-17) was assessed at baseline and weekly for 4 weeks. Pearson correlation and receiver operating characteristic curves (ROC) analyses were used to explore the relationship between brain imaging indicators and antidepressant efficacy.ResultsThe difference between therapeutically effective and ineffective groups was mainly manifested in the beta power of the SN. The FC of beta waves between the three networks was related to antidepressant efficacy, with ROC analysis results of AUC = 0.794,P= 0.004, sensitivity = 76.7%, and specificity = 81.8%.LimitationsThe sample size was small and a healthy control group was not available.ConclusionsThe interaction between the three networks is related to antidepressant efficacy and the relief of depressive symptoms.
In-patient Expenditure Between 2012 and 2020 Concerning Patients With Liver Cirrhosis in Chongqing: A Hospital-Based Multicenter Retrospective Study
Authors: Tan Juntao , Tang Xuewen , He Yuxin , Xu Xiaomei , Qiu Daoping , Chen Jianfei , Zhang Qinghua , Zhang Lingqin 
Published: March 2022

BackgroundLiver cirrhosis is a major global health and economic challenge, placing a heavy economic burden on patients, families, and society. This study aimed to investigate medical expenditure trends in patients with liver cirrhosis and assess the drivers for such medical expenditure among patients with liver cirrhosis.MethodsMedical expenditure data concerning patients with liver cirrhosis was collected in six tertiary hospitals in Chongqing, China, from 2012 to 2020. Trends in medical expenses over time and trends according to subgroups were described, and medical expenditure compositions were analyzed. A multiple linear regression model was constructed to evaluate the factors influencing medical expenditure. All expenditure data were reported in Chinese Yuan (CNY), based on the 2020 value, and adjusted using the year-specific health care consumer price index for Chongqing.ResultsMedical expenditure for 7,095 patients was assessed. The average medical expenditure per patient was 16,177 CNY. An upward trend in medical expenditure was observed in almost all patient subgroups. Drug expenses were the largest contributor to medical expenditure in 2020. A multiple linear regression model showed that insurance type, sex, age at diagnosis, marital status, length of stay, smoking status, drinking status, number of complications, autoimmune liver disease, and the age-adjusted Charlson comorbidity index score were significantly related to medical expenditure.ConclusionConservative estimates suggest that the medical expenditure of patients with liver cirrhosis increased significantly from 2012 to 2020. Therefore, it is necessary to formulate targeted measures to reduce the personal burden on patients with liver cirrhosis.
Velopharyngeal Inadequacy-Related Quality of Life Assessment: The Instrument Development and Application Review
Authors: Chen Nan , Shi Bing , Huang Hanyao 
Published: March 2022

ObjectiveFor the patient-reported outcome (PRO) measures related to patients with velopharyngeal inadequacy (VPI), different quality of life (QOL) instruments have been developed. The present systematic review was designated to identify current VPI-related QOL instrument development, validation, and applicability.MethodsPubmed, Cochrane, Embase, Web of Science, and EBSCO databases were searched in January 2022. “Velopharyngeal” or “palatopharyngeal” and “quality of life” or “life quality” were searched in title, abstract, and keywords. This study followed Preferred Reporting Items for Systematic Review and Meta-analysis (PRISMA) guidelines. Two investigators independently reviewed abstracts and full texts of the identified literature. An established checklist was used to evaluate the measurement properties of each identified instrument.ResultsA total of 375 articles and 13 instruments were identified, which can be divided into nine types of families according to their development procedures. Developmental and measurement characteristics, evidence of conceptual model, content validity, reliability, construct validity, scoring, interpretation, respondent burden, and presentation for all instruments were shown.ConclusionThe patient's self-report assessment and parent-proxy assessment are both valuable. The conclusion that any QOL instrument is absolutely the best for patients with velopharyngeal inadequacy could not be drawn. Understanding the development and characteristics of different QOL instruments, including their reliability, validity, aim, target, language, and resource, should be important before application in clinic or research.
Impact of Preoperative Type 2 Diabetes Mellitus on the Outcomes of Gastric Cancer Patients Following Gastrectomy: A Propensity Score Matching Analysis
Authors: Cheng Yu-Xi , Tao Wei , Kang Bing , Liu Xiao-Yu , Yuan Chao , Zhang Bin , Peng Dong 
Published: March 2022

PurposeThe current study aims to explore the outcomes of type 2 diabetes mellitus (T2DM) on gastric cancer patients following gastrectomy through propensity score matching (PSM) analysis.MethodsA retrospective study of gastric cancer patients following gastrectomy was conducted in a single clinical center from January 2014 to December 2019. The short-term outcomes, overall survival (OS) and disease-free survival (DFS) were analyzed between T2DM group and Non-T2DM group.ResultsA total of 703 patients were enrolled in this study. After 1:1 PSM, 84 patients in T2DM group and 84 patients in Non-T2DM were matched for final analysis. No significant difference was found in terms of operation time, intra-operative blood loss, retrieved lymph nodes, postoperative stay, blood transfusion and complications between T2DM group and Non-T2DM group (p &gt; 0.05). The Kaplan-Meier curve implied that T2DM had no impact on OS or DFS. Cox regression was conducted to identify predictive factors for prognosis. Body mass index (BMI) (p = 0.039 &lt; 0.05, HR = 0.725, 95% CI = 0.534–0.983), pre-operative lymphocyte (p = 0.017 &lt; 0.05, HR = 0.678, 95% CI = 0.493–0.932), pathological tumor node metastasis (pTNM) stage (p = 0.000 &lt; 0.05, HR = 2.619, 95% CI = 2.048–3.349) and complications (p = 0.006 &lt; 0.05, HR = 1.528, 95% CI = 1.132–2.061) were predictive factors for OS, and BMI (p = 0.013 &lt; 0.05, HR = 0.524, 95% CI = 0.315–0.872), pTNM stage (p = 0.000 &lt; 0.05, HR = 2.619, 95% CI = 2.048–3.349) and complications (p = 0.008 &lt; 0.05, HR = 1.892, 95% CI = 1.179–3.036) were independent predictive factors for DFS.ConclusionT2DM did not have an impact on gastric cancer patients following gastrectomy in terms of short-term outcomes and prognosis.
Bone Mass and Osteoblast Activity Are Sex-Dependent in Mice Lacking the Estrogen Receptor α in Chondrocytes and Osteoblast Progenitor Cells
Authors: Steppe Lena , Bülow Jasmin , Tuckermann Jan , Ignatius Anita , Haffner-Luntzer Melanie 
Published: March 2022

While estrogen receptor alpha (ERα) is known to be important for bone development and homeostasis, its exact function during osteoblast differentiation remains unclear. Conditional deletion of ERα during specific stages of osteoblast differentiation revealed different bone phenotypes, which were also shown to be sex-dependent. Since hypertrophic chondrocytes can transdifferentiate into osteoblasts and substantially contribute to long-bone development, we aimed to investigate the effects of ERα deletion in both osteoblast and chondrocytes on bone development and structure. Therefore, we generated mice in which the ERα gene was inactivated via a Runx2-driven cyclic recombinase (ERαfl/fl; Runx2Cre). We analyzed the bones of 3-month-old ERαfl/fl; Runx2Cre mice by biomechanical testing, micro-computed tomography, and cellular parameters by histology. Male ERαfl/fl; Runx2Cre mice displayed a significantly increased cortical bone mass and flexural rigidity of the femurs compared to age-matched controls with no active Cre-transgene (ERαfl/fl). By contrast, female ERαfl/fl; Runx2Cre mice exhibited significant trabecular bone loss, whereas in cortical bone periosteal and endosteal diameters were reduced. Our results indicate that the ERα in osteoblast progenitors and hypertrophic chondrocytes differentially contributes to bone mass regulation in male and female mice and improves our understanding of ERα signaling in bone cells in vivo.
MENGUPAS PRAKTIK PENGELOLAAN ADMINISTRASI KEUANGAN KANTOR KECAMATAN
Authors: Nora Erfianingtyas  , Wahyudi Utomo Supri , Wahyuning Sulistyowati Nur 
Published: March 2022

The purpose of this study was to find out more about the financial administration management practices of the West District Head Office, West District, Magetan Regency. This type of qualitative research is descriptive and data obtained from interviews, observations, and documentation. The study resulted in the findings that the West Camat office in managing financial administration is in accordance with Permendagri No.64 of 2013 and the financial information compiled includes LRA; LO; balance sheet; LPE; and CaLK. The obstacles faced by the sub-district office are delays in the preparation and reporting of financial information, besides that the compilers of financial information at the West sub-district office are not from the accounting department.
Abstrak
Tujuan penelitian ini mengetahui lebih jauh praktik pengelolaan administrasi keuangan Kantor Camat Barat Kecamatan Barat Kabupaten Magetan. Jenis penelitian kualitatif deskriptif dan data didapatkan dari interview, pengamatan, dan dokumentasi. Penelitian menghasilkan temuan bahwa kantor Camat Barat dalam pengelolaan administrasi keuangan sudah sesuai Permendagri No.64 Tahun 2013 dan informasi finansial yang disusun meliputi LRA; LO; Neraca; LPE; dan CaLK. Hambatan yang dihadapi kantor camat adalah keterlambatan dalam penyusunan dan pelaporan informasi finansial, selain itu penyusun informasi finansial pada kantor Camat Barat bukan berasal dari jurusan akuntansi.
Conjunctivitis due to COVID-19
Authors: Polii Marsekal K. , Supit Wenny P. , Najoan Imelda H. M. 
Published: March 2022

Abstract: COVID-19 is a respiratory infectious disease due to SARS-CoV-2 virus. This virus requires angiotensin-converting enzyme 2 (ACE2) receptor to invade cells. ACE2 receptors are also found in the conjunctiva, therefore, the surface tissue of the eye can be a potential target for COVID-19 transmission. The most common ocular manifestation of COVID-19 is conjunctivitis. This study aimed to evaluate whether there was a relationship between conjunctivitis and COVID-19 disease. This was a literature review study using four databases, namely Pubmed, Google Scholar, Science Direct and Clinical Key. The keywords were COVID-19 AND conjunctivitis. The results showed that conjunctivitis due to COVID-19 could be one or the only symptom. The age range of COVID-19 positive samples with conjunctivitis symptoms was dominated by middle-aged to elderly. More often the patients had moderate to asymptomatic degree of symptoms. Supportive therapies such as artificial tear drops and cold compresses greatly helped the healing process. In conclusion, the transmission of COVID-19 infection due to SARS-CoV-2 virus can spread through the conjunctiva. Conjunctivitis can be the only symptom that appears due to COVID-19 infection or as an early sign of infection.Keywords: conjunctivitis; COVID-19 Abstrak: COVID-19 merupakan penyakit infeksi menular pernapasan yang diakibatkan oleh virus SARS-CoV-2. Virus ini membutuhkan reseptor angiotensin-converting enzyme 2 (ACE2) untuk menginvasi sel-sel. Reseptor ACE2 juga ditemukan pada konjungtiva sehingga jaringan permukaan mata dapat menjadi target potensial untuk penularan COVID-19. Manifestasi okular akibat COVID-19 yang sering ditemukan ialah konjungtivitis. Penelitian ini bertujuan untuk mengevaluasi apakah terdapat hubungan antara konjungtivitis dengan COVID-19. Jenis penelitian ialah suatu literature review. Pencarian data menggunakan empat database Pubmed, Google Scholar, Science Direct dan Clinical Key dengan kata kunci yaitu COVID-19 AND conjunctivitis. Hasil penelitian mendapatkan bahwa konjungtivitis akibat COVID-19 dapat menjadi salah satu maupun satu-satunya gejala. Rentang usia sampel positif COVID-19 dengan gejala konjungtivitis didominasi oleh middle-aged sampai lanjut usia dan lebih sering pasien derajat gejala asimt-omatik-sedang. Terapi suportif seperti pemberian tetes air mata buatan dan kompres dingin sangat membantu proses penyembuhan. Simpulan penelitian ini ialah penularan infeksi COVID-19 yang disebabkan oleh virus SARS-CoV-2 dapat menyebar melalui konjungtiva. Konjungtivitis dapat menjadi satu-satunya gejala yang muncul akibat infeksi COVID-19 maupun sebagai tanda awal infeksi.Kata kunci: konjungtivitis; COVID-19
Thermal nanoimprint lithography of sodium hyaluronate solutions with gas permeable inorganic hybrid mold for cosmetic and pharmaceutical applications
Authors: Yamagishi Rio , Miura Sayaka , Yasuda Kaori , Sugino Naoto , Kameda Takao , Kawano Yuki , Yokoyama Yoshiyuki , Takei Satoshi 
Published: March 2022

Abstract
Gas-permeable inorganic hybrid mold that hybridized the surface layer of TiO2–SiO2 gas-permeable polymer using the sol–gel method and the lower layer of porous maraging steel by a metal three-dimensional printer was developed for fluid function materials containing high concentrations of water and volatile solvents. Thermal nanoimprint lithography was used to fabricate the advanced high-resolution needle patterning of sodium hyaluronate containing volatile solvents to broaden the application area of fluid function materials such as cosmetics and pharmaceuticals.