bluuebunny/crossref_metadata_2025_split huggingface dataset:
Difference in postural stability between STarT Back Tool subgroups of patients with low back pain under conditions of sensory deprivation and cognitive load
Authors: Ingemann-Molden Stian , Pessoto Hirata Rogerio , Bach Jensen Martin , Graven-Nielsen Thomas , Riis Allan 
Published: July 2022

Objective We explored differences in postural stability between subgroups of patients with low back pain (LBP) and varying risk levels for developing chronicity measured using the Subgroups for Targeted Treatment (STarT) Back Tool. Methods This was a cross-sectional, single-session, double-blind experimental study among 65 participants who had LBP for more than 14 days. Postural stability was assessed by measuring the center of pressure (COP) range, displacement area, and velocity in anterior–posterior and mediolateral directions under four sensory and cognitive conditions: (i) eyes open and counting forward, (ii) eyes closed and counting forward, (iii) eyes closed and counting forward in multiples of seven, and (iv) eyes closed and counting backward in multiples of seven. The participants were stratified into low-/medium- (n = 53) and high-risk (n = 9) subgroups. Results There were no significant between-group differences among patients with LBP stratified as having a low/medium or high risk of chronicity in postural stability and sensory and cognitive conditions. Conclusions Impaired postural stability is important to consider when treating patients with LBP. However, we found that these impairments were not strongly aggravated in groups with a higher risk of chronicity, as measured using the STarT Back Tool.
A Turkish Translation of Genji Monogatari
Authors: Baykara Oğuz 
Published: July 2022

AbstractThe Tale of Genji(Genji Monogatari) is the probably the earliest prose fiction in the world that still lives today as a masterpiece since the first decade of the 11th century. This 1200-page Japanese classic was written by a noble court woman, Murasaki Shikibu, and it spans almost three quarters of a century. The first part has to do with the life and loves of the nobleman known as “The Shining Genji”, and the final chapters follow the fate and fortunes of the characters that survived after Genji's death.There have been four English translations of the novel: one partial translation (1882) by a Japanese translator and three other complete translations by different English native speakers in the 20th century.This paper studies the Turkish translation process ofThe Tale of Genjifrom Edward G. Seidensticker's English version. It points out the plentitude of potential translation choices and tries to explore the reasons of translators for their decisions. It compares the translators’ strategies and assesses their impact on the meanings and functions of the allusions and the connections between the adopted strategies.
An Examination of Conditions Exposing Older Adults to Economic Abuse: Logistic Regression Analysis
Authors: Ünlü Derya , Yurtsever Emel , Artan Taner , Irmak Hatice Selin 
Published: July 2022

The aim of this study was to determine factors affecting the economic abuse status of older adults. The study was conducted with 385 individuals aged 65 years and above, living in the Bahçelievler district of Istanbul. Data were collected using a Sociodemographic Form, and a Determination of Economic Abuse of Older Adults Form. Logistic regression analysis was applied to determine the factors affecting the economic abuse status of the older adults. The study participants comprised 51.4% males and 48.6% females with a mean age of 70.44 ± 6.73 years. It was determined that 9.4% of the older adults were exposed to economic abuse. As a result of the logistic regression analysis, the factors found to affect the situations of exposure to economic abuse of the older adults were age, income status, number of children, exposure to emotional abuse, and exposure to physical abuse.
Modified Abdominal Skin Resection: A Novel Approach to High-Definition Body Contouring of the Abdomen
Authors: Skenderian Shea , Sin Zachary , Mirzania Hamid , Mowlavi Arian 
Published: July 2022

Introduction: We present a novel abdominal contouring procedure, called the modified abdominal skin resection, designed to maximize elimination of skin redundancy while allowing for simultaneous high-definition liposuction of the entire abdominal skin flap. Technical details of the modified abdominal skin resection will be presented including inclusion and exclusion criteria, complications, and outcomes. Materials and Methods: Strategic limiting of abdominal skin undermining, preserving of any visible perforators, using ultrasound liposuction, and if necessary, administering Renuvion J plasma skin contraction are components of the presented high-definition abdominal contouring procedure. Limited undermining allows for high-definition liposuction of the abdomen to create muscle highlights and smooth contour junctions. Results: We present case studies demonstrating superior contour results when compared to traditional tummy tucks without muscle plication or liposuction alone. We present technical details of the modified abdominal skin resection, inclusion and exclusion criteria, complications, and outcomes. Discussion: The modified abdominal skin resection allows for high definition abdominoplasty outcomes. These results are superior to traditional abdominoplasties that are performed without muscle plication. This novel abdominoplasty procedure allows for aggressive removal of fat, as well as maximal elimination of skin redundancy and laxity. Inclusion and exclusion criteria established in this paper dicatate whether a patient is a good candidate for the modified abdominal skin resection. Conclusion: We present technical details required to complete the high definition abdominoplasty without muscle plication which allows for waistline snatching and creation of abdominal muscle highlights. High definition body contouring principles are applied to the modified abdominal skin resection to achieve superior body contouring results.
Fentanyl-Induced Rigid Chest Syndrome in Critically Ill Patients
Authors: Tammen Alison J. , Brescia Donald , Jonas Dan , Hodges Jeremy L. , Keith Philip 
Published: July 2022

Background Opioid induced chest wall rigidity was first described in the early 1950s during surgical anesthesia and has often been referred to as fentanyl induced rigid chest syndrome (FIRCS). It has most commonly been described in the setting of procedural sedation and bronchoscopy, characterized by pronounced abdominal and thoracic rigidity, asynchronous ventilation, and respiratory failure. FIRCS has been infrequently described in the setting of continuous analgesia in critically ill adult patients. We postulate that FIRCS can occur in this setting and is likely under recognized, leading to increased morbidity and mortality. Methods Patients admitted to the intensive care unit with suspected FIRCS were included in this retrospective analysis. The objective of this analysis is to describe the clinical presentation and treatment strategies for FIRCS. Results Forty-two patients exhibiting symptoms of FIRCS were included in this analysis. Twenty-two of the forty-two patients with descriptive documentation had evidence of thoracic or abdominal rigidity on examination (52.4%). Twelve of sixteen (75%) patients treated solely with naloxone had documented ventilator compliance following intervention, compared to six of eleven (55%) managed with cisatracurium alone. Nine of twelve patients who ultimately received naloxone after initial treatment with cisatracurium had documented ventilator compliance following naloxone administration (75%). Standard interventions, including sedation optimization and ventilator adjustments were attempted to rule out and treat other potential causes of dyssynchrony. In most cases, the administration of naloxone resulted in appropriate compliance with both ventilator and patient-initiated breaths, suggesting the ventilator dyssynchrony was due to fentanyl. Conclusions This is the largest case series to date describing FIRCS in the intensive care setting. Recognition and prompt management is necessary for improved patient outcomes. Research is needed to increase awareness and recognition, identify patient risk factors, and analyze the efficacy and safety of interventions.
Is non-occupational HIV Post Exposure Prophylaxis (nPEP) still used? An exploration of nPEP use since widespread availability of HIV PrEP
Authors: Woodward Shannon C , Baynes Anne M , Tyson Hayley A , Dunlop William A , Martin Sarah J 
Published: July 2022

Background Non-occupational Post-Exposure Prophylaxis (nPEP) is an effective HIV prevention strategy in gay and bisexual men (GBM) taken after possible exposure. HIV Pre-Exposure Prophylaxis (PrEP) is also a highly effective HIV prevention strategy. Methods A retrospective audit of medical records of GBM presenting to a sexual health centre and provided with nPEP compared two periods to determine if nPEP usage changed following availability of PrEP. In the first period (P1) PrEP was available through extended trials. In the second period (P2) PrEP became more accessible through the Australian Pharmaceutical Benefits Scheme (PBS). Period comparisons were performed using a two-population test of proportions with one-tailed testing and significance set at P < .05 using SPSS Statistics Version 25. Results There were 232 GBM provided with nPEP in P1, and 202 in P2. A two-population test of proportions demonstrated that GBM presentations for nPEP decreased significantly from 302/4779 (6.3%) of GBM visits in P1 to 221/7205 (3.1%) in P2 when PrEP was more accessible (Z=8.53, P < .001). PrEP uptake after presenting for nPEP increased from 30 (12.9%) of total GBM visits in P1 to 69 (34.2%) in P2 (Z=5.26, p < .001). Conclusions GBM accessing nPEP decreased with statistical significance post introduction of PBS PrEP.
Structural Barriers to HIV Prevention and Services: Perspectives of African American Women in Low-Income Communities
Authors: Rimmler Shelby , Golin Carol , Coleman James , Welgus Hayley , Shaughnessy Sarah , Taraskiewicz Leah , Lightfoot Alexandra F. , Randolph Schenita D. , Riggins Linda 
Published: July 2022

Background African American women are at a disproportionate HIV risk compared with other U.S. women. Studies show that complex structural and social determinants, rather than individual behaviors, place African American women at greater risk of HIV infection; however, little is known about women’s views of what puts them at risk. Aims This study sought to comprehend the perceptions of African American women living in low-income housing regarding the factors that influence both their personal sexual health behaviors and use of HIV prevention services. Methods We conducted seven focus groups with 48 African American women from 10 public housing communities in a small city in the southeastern United States. We analyzed the focus group transcripts using thematic data analysis to identify salient themes and points of interest related to the study aim. Results Women identified factors related to the health care system (trustworthiness of the health care system), the external environment (racism, classism, patriarchal structures, and violence/crime), as well as predisposing (health beliefs, stigma, and gender norms), enabling (agency to negotiate gendered power), and need (perceived HIV risk and perceptions of partner characteristics) features of individuals in the population. Conclusion African American women living in public housing are especially vulnerable to HIV infection due to intersectional discrimination based on racism, classism, gender power dynamics, and community conditions. Our findings confirm the need to develop HIV intervention programming addressing intersectional identities of those making up the communities they plan to address, and being informed by those living in the communities they plan to act on.
Harmol alleviates dimethylhydrazine induced colon cancer by downregulating Bcl2/IL-6/TNF-α expression in association with p53 mediated apoptosis
Authors: Guo Ni , Gao Jie 
Published: July 2022

Objectives: Colorectal cancer is the world’s third most prevalent cancer. Herbal drugs are increasingly being used to treat a variety of disorders, including cancer, due to the severe adverse effects. Harmol, natural molecule containing β-carboline alkaloids, has aroused the interest of researchers due to its diverse biological functions, including anticancer properties. Methods: In this study, the chemotherapeutic effects of harmol have been investigated on HT-29 colon cancer cell line and a rat model of colon cancer. In the in vitro study the cytotoxicity assay, DAPI analysis and the flow cytometric analysis was performed to assess the anticancer efficacy of harmol in HT-29 cell. The colorectal cancer was developed in male Wistar rats through the administration of DMH followed by treatment with DSS. The rats were treated with harmol (100, 200 and 400 mg/kg) for 18 weeks. At the end of therapy, the colon tissues were assessed for ACF, in vivo antioxidant activity, histopathology, immunohistochemistry, immunofluorescence analysis and apoptosis assay. Results: The in vitro data suggested that the harmol therapy would significantly increase the percentage of early apoptosis in HT-29 cells through halting of G0/G1 phase. Furthermore, inhibition of ACF development with improved colonic abrasion and morphological features in colonic mucosal region were noted. Harmol treatment also increased the levels of antioxidants and p53 and downregulated Bcl2, IL-6 and TNF-α expression. Conclusion: These outcomes signify that harmol successfully recover colorectal carcinoma by reprogramming the p53, Bcl2, IL-6 and TNF-α pathway in rats.
Use of Continuous Glucose Monitors by People Without Diabetes: An Idea Whose Time Has Come?
Authors: Klonoff David C. , Nguyen Kevin T. , Xu Nicole Y. , Gutierrez Alberto , Espinoza Juan C. , Vidmar Alaina P. 
Published: July 2022

Background: Continuous glucose monitor (CGM) systems were originally intended only for people with diabetes. Recently, there has been interest in monitoring glucose concentrations in a variety of other situations. As data accumulate to support the use of CGM systems in additional states unrelated to diabetes, the use of CGM systems is likely to increase accordingly. Methods: PubMed and Google Scholar were searched for articles about the use of CGM in individuals without diabetes. Relevant articles that included sufficient details were queried to identify what cohorts of individuals were adopting CGM use and to define trends of use. Results: Four clinical user cases were identified: (1) metabolic diseases related to diabetes with a primary dysregulation of the insulin-glucose axis, (2) metabolic diseases without a primary pathophysiologic derangement of the insulin-glucose axis, (3) health and wellness, and (4) elite athletics. Seven trends in the use of CGM systems in people without diabetes were idenfitied which pertained to both FDA-cleared medical grade products as well as anticipated future products, which may be regulated differently based on intended populations and indications for use. Conclusions: Wearing a CGM has been used not only for diabetes, but with a goal of improving glucose patterns to avoid diabetes, improving mental or physical performance, and promoting motivate healthy behavioral changes. We expect that clinicians will become increasingly aware of (1) glycemic patterns from CGM tracings that predict an increased risk of diabetes, (2) specific metabolic glucotypes from CGM tracings that predict an increased risk of diabetes, and (3) new genetic and genomic biomarkers in the future.
Sleep and the Young Athlete
Authors: Coel Rachel A. , Pujalte George G.A. , Applewhite Andres I. , Zaslow Tracy , Cooper George , Ton Angie N. , Benjamin Holly J. 
Published: July 2022

Context: Sleep plays a vital role in cognitive and physical performance. Teenage athletes (ages 13-19 years) are considered especially at risk for disordered sleep and associated negative cognitive, physical, and psychosomatic effects. However, there is a paucity of evidence-based recommendations to promote sleep quality and quantity in athletes who fall within this age range. We performed a review of the literature to reveal evidence-based findings and recommendations to help sports instructors, athletic trainers, physical therapists, physicians, and other team members caring for young athletes provide guidance on sleep optimization for peak sports performance and injury risk reduction. Methods: PubMed, Scopus, and Cochrane CENTRAL were searched on May 11, 2016, and then again on September 1, 2020, for relevant articles published to date. Study Design: Narrative review. Level of Evidence: Level 4. Results: Few studies exist on the effects disordered sleep may have on teenage athletes. By optimizing sleep patterns in young athletes during training and competitions, physical and mental performance, and overall well-being, may be optimized. Adequate sleep has been shown to improve the performance of athletes, although further studies are needed. Conclusion: Twenty-five percent of total sleep time should be deep sleep, with a recommended sleep time of 8 to 9 hours for most young athletes. Screen and television use during athletes’ bedtime should be minimized to improve sleep quality and quantity. For young athletes who travel, jet lag can be minimized by allowing 1 day per time zone crossed for adjustment, limiting caffeine intake, planning meals and onboard sleeping to coincide with destination schedules, timing arrivals in the morning whenever possible, and using noise-canceling headphones and eyeshades. Strength-of-Recommendation Taxonomy (SORT): B.
Exploring the use of a Ruthenium complex incorporated into a methacrylate-based dental material for antimicrobial photodynamic therapy
Authors: Manso Adriana Pigozzo , Leite Maria Luísa , Comeau Patricia , Dietrich Claudia , Ghaffari Sahand , Lange Dirk , Branda Neil 
Published: July 2022

Objectives: To evaluate the effects of a blue light photosensitizer (PS), Ruthenium II complex (Ru), on the chemical, physical, mechanical, and antimicrobial properties of experimental dental resin blends. Methods: The experimental resin (BisEMA, TEEGDMA, HPMA, ethanol, and photoinitiator) was loaded with Ru at 0.00%, 0.07%, 0.14%, 0.28%, 0.56%, 1.12%, 1.2%, 1.5%, 2%, 3%, 4%, 5%, 6%, 7%, 8%, 9%, or 10% w/w. Samples were evaluated for the degree of conversion (DC) after 30 and 60 s curing-time ( n = 6). Selected formulations (0.00%, 0.28%, 0.56%, 1.12%) were further tested for shear bond strength (SBS) ( n = 15); flexural strength (FS) ( n = 12); and antimicrobial properties (CFUs), in dark and light conditions. These latter tests were performed on specimens stored for 24-h or 2-month in 37°C water. Water sorption (WS) and solubility (SL) tests were also performed ( n = 12). Data were analyzed either by a one- or two-factor general linear model (α = 0.05). Results: Overall, Ru concentration above 1.2% resulted in reduced DC. In SBS results, only the 1.12%Ru resin blend samples had statistically lower values compared to the 0.00%Ru resin blend at 24-h storage ( p = 0.004). In addition, no differences in SBS were detected among the experimental groups after 2-month storage in water. Meanwhile, FS increased for all experimental groups under similar aging conditions ( p < 0.001). Antimicrobial properties were improved upon inclusion of Ru and application of light ( p < 0.001 for both) at 24-h and 2-month storage. Lastly, no detectable changes in WS or SL were observed for the Ru-added resins compared to the 0.00%Ru resin blend. However, the 0.28% Ru blend presented significantly higher WS compared to the 0.56% Ru blend ( p = 0.007). Conclusions: Stable SBS, improved FS, and sustained antimicrobial properties after aging gives significant credence to our approach of adding the Ruthenium II complex into dental adhesive resin blends intended for an aPDT approach.
Anesthesia promotes acute expression of genes related to Alzheimer’s disease and latent tau aggregation in transgenic mouse models of tauopathy
Authors: Eun John David , Jimenez Heidy , Adrien Leslie , Wolin Adam , Marambaud Philippe , Davies Peter , Koppel Jeremy L. 
Published: July 2022

Abstract
Background
Exposure to anesthesia in the elderly might increase the risk of dementia. Although the mechanism underlying the association is uncertain, anesthesia has been shown to induce acute tau hyperphosphorylation in preclinical models. We sought to investigate the impact of anesthesia on gene expression and on acute and long-term changes in tau biochemistry in transgenic models of tauopathy in order to better understand how anesthesia influences the pathophysiology of dementia.

Methods
We exposed mice with over-expressed human mutant tau (P301L and hyperdopaminergic COMTKO/P301L) to two hours of isoflurane and compared anesthetized mice to controls at several time points. We evaluated tau hyperphosphorylation with quantitative high-sensitivity enzyme-linked immunosorbent assay and performed differential expression and functional transcriptome analyses following bulk mRNA-sequencing.

Results
Anesthesia induced acute hyperphosphorylation of tau at epitopes related to Alzheimer’s disease (AD) in both P301L-based models. Anesthesia was associated with differential expression of genes in the neurodegenerative pathways (e.g., AD-risk genes ApoE and Trem2) and thermogenesis pathway, which is related to both mammalian hibernation and tau phosphorylation. One and three months after anesthesia, hyperphosphorylated tau aggregates were increased in the anesthetized mice.

Conclusions
Anesthesia may influence the expression of AD-risk genes and induce biochemical changes in tau that promote aggregation even after single exposure. Further preclinical and human studies are necessary to establish the relevance of our transcriptomic and biochemical findings in these preclinical models to the pathogenesis of dementia following anesthesia.
Trial registration: Not applicable.
OsSNDP3 Functions for the Polar Tip Growth in Rice Pollen Together with OsSNDP2, a Paralog of OsSNDP3
Authors: Moon Sunok , Kim Yu-Jin , Park Ha Eun , Kim Junhyup , Gho Yun Shil , Hong Woo-Jong , Kim Eui-Jung , Lee Su Kyoung , Suh Byung-Chang , An Gynheung , Jung Ki-Hong 
Published: July 2022

AbstractUnderstanding pollen tube growth is critical for crop yield maintenance. The pollen tube provides a path for sperm cells for fertilization with egg cells. Cells must be subdivided into functionally and structurally distinct compartments for polar tip growth, and phosphoinositides are thought to be one of the facilitators for polarization during pollen tube growth. OsSNDP3 encodes Sec14-nodulin domain-containing protein and localizes in the nucleus and the microdomains of the plasma membrane in tobacco leaf epidermis cells. OsSNDP3 is thought to bind with phosphatidylinositol 4,5-bisphosphate based on the data including the information of basic amino acids in the C-terminal and colocalization with 2X Pleckstrin homology domain of Phospholipase C delta-1. OsSNDP3 interacts with a protein that contains a class I nodulin domain. We discovered that OsSNDP3 plays a significant role in pollen tube germination using CRISPR/Cas9 systems, whereas another pollen-preferential Sec14-nodulin domain-containing protein, OsSNDP2, additively functions with OsSNDP3 during pollen tube germination. Gene Ontology analysis using downregulated genes in ossndp3 indicated that the expression of genes involved in the phosphatidylinositol metabolic process and tip growth was significantly altered in ossndp3. OsSNDP3 aids pollen polar tip growth by binding with phosphatidylinositol 4,5-bisphosphate. We can better understand the roles of phosphoinositides during pollen tube growth by studying the functions of OsSNDP3 and OsSNDP2. And downregulated genes in ossndp3 might be useful targets for future research on polar tip growth.