bluuebunny/crossref_metadata_2025_split huggingface dataset:
Сomorbidity of coronary artery disease and its significance in predicting the results of coronary artery bypass grafting
Authors: Rublev V. Yu. , Geltser B. I. , Sergeev E. A. , Kotelnikov V. N. , Karpov R. S. 
Published: April 2022

The review presents an analysis of the scientific literature on comorbidity of coronary artery disease (CAD) and assessment of its impact on the results of coronary artery bypass grafting (CABG). Arterial hypertension (AH), chronic obstructive pulmonary disease (COPD), metabolic syndrome (MS), and diabetes mellitus (DM) have been shown to be the most common comorbidities in CAD patients. Clinical manifestations of cardiovascular comorbidities also include atrial fibrillation, acute cerebral ischemia, atherosclerosis of carotid and lower limb arteries, and chronic heart failure.Concomitant COPD doubles the risk of postoperative complications after CABG and reduces the 10-year survival rate in patients to 30%. In CAD patients with MS, the risk of postoperative mortality increases by 1.4 times, and the 5-year survival rate decreases by 3 times. Diabetes significantly worsens the long-term survival of patients after CABG and is an independent predictor of acute cardiovascular events after revascularization in the long term. The presence of various comorbidities in CAD patients requires a personalized approach to managing the risks of adverse outcomes after CABG and introduction of modern artificial intelligence (AI) technologies into clinical practice, which significantly increase the accuracy of prognosis.
Implantable cardioverter-defibrillators in sudden cardiac death prevention: guidelines and clinical practice (literature review)
Authors: Talibullin I. V. , Lebedeva N. B. 
Published: April 2022

Implantable cardioverter-defibrillators (ICDs) are considered to be the most beneficial in preventing sudden cardiac death (SCD), especially in patients with reduced left ventricular ejection fraction (LVEF). However, major large-scale randomized clinical trials on ICD effectiveness were conducted 20 years ago and do not reflect current realities. Modern ICDs and methods for treating heart failure have drastically improved. New clinical reality requires reconsideration of approaches to determining the risk of SCD and indications for ICD, personalization of device selection and programming, and identification of barriers that prevent ubiquitous use of the method in real clinical practice.The article reviews the available evidence base on the use of ICDs, current clinical guidelines, complications following the device implantation, and any difficulties associated with ICD application in routine clinical practice.
Study of the anti-inflammatory and immunotropic activity of the secretome from multipotent mesenchymal stromal cells induced by erythropoietin, valproic acid or dexamethasone <i>in vitro</i>
Authors: Golubinskaya P. A. , Puzanov M. V. , Sarycheva M. V. , Burda S. Yu. , Nadezhdin S. V. , Korokin M. V. , Burda Yu. E. 
Published: April 2022

The aim of this study was to evaluate the effect of treatment with valproic acid, erythropoietin, and dexamethasone on the anti-inflammatory and immunosuppressive activity of the secretome of adipose-derived multipotent mesenchymal stromal cells (MMSCs) in an in vitro experiment.Materials and methods. MMSCs were isolated from the fat of 6 healthy donors. The cells were grown in the culture up to passage 4. Then they were treated with valproic acid, erythropoietin or dexamethasone for 3 hours, washed from preparations, and incubated in a serum-free medium for 48 hours. Some of the cells were not treated with preparations. Supernatants from the cell cultures were concentrated by ultrafiltration, and protein standardization was performed using a nanophotometer. Then the supernatants were sterilized and added to mononuclear cells from peripheral blood of 8 healthy donors. The mononuclear cells were isolated by Ficoll density gradient centrifugation according to the standard protocol. Concentrations of TNFα, IL-2, IL-4, IL-6, IL-10, and IFNγ cytokines in 24-hour cultures and IL-9, IL-10, IL-17A, and IL-21 cytokines in 48-hour cultures were determined using multiplex analysis.Results. The production of IL-2, IL-6, TNFα, and IL-10 was reduced by the secretome of MMSCs treated with valproic acid. The production of IL-2, IL-6, and TNFα decreased during incubation of the mononuclear cells with the secretome of MMSCs treated with erythropoietin. The secretome of dexamethasone-treated MMSCs suppressed the production of IFNγ, IL-1β, IL-1ra, IL-2, IL-6, IL-9, IL-10, and IL-17A. No statistically significant differences were revealed in the production of IL-4, IL-5, IL-9, and IL-21.Conclusion. Among the studied inducers, dexamethasone enhanced the anti-inflammatory and immunosuppressive activity of MMSCs the most, which was manifested through the effect of their supernatants on peripheral blood mononuclear cells.
Effect of local ozone therapy on inflammatory markers in experimental ulcerative colitis
Authors: Davydova E. V. , Osikov M. V. , Kaygorodtseva N. V. 
Published: April 2022

Aim. To evaluate the effect of rectal insufflations of medical ozone on markers of inflammation in experimental ulcerative colitis.Materials and methods. The experimental study was performed in vivo on 49 white, sexually mature male Wistar rats weighing 250 ± 15 g. The model of ulcerative colitis was reproduced using two-stage oxazolone administration (Sigma-Aldrich, USA). A group of animals received rectal insufflations of medical ozone at a dose of 1.0 mg / l once a day in the volume of 10 ml of ozone / oxygen mixture. The cycle of insufflations lasted 10 days. The ozone / oxygen mixture was obtained using an automated ozone therapy device with an ozone destructor UOTA-60-01“Medozon” (Medozon LLC, Moscow, Russian Federation). According to the disease activity index (DAI) score, the disease activity index was evaluated. The intensity of neutrophil phagocytosis in the blood was detected using polystyrene latex particles. The ability of neutrophils to reduce nitroblue tetrazolium (NBT) was determined using spontaneous and induced NBT tests. The interleukin-17 (IL-17) concentration in the serum was determined by enzyme-linked immunosorbent assay (ELISA) using a test system for rats manufactured by Bender MedSystems (Austria).Results. Under the conditions of ozone therapy by rectal insufflations in experimental ulcerative colitis, we demonstrated improvement in the clinical presentation of the disease, intensity of phagocytosis, phagocytic index, and spontaneous and induced ability of neutrophils to reduce NBT with normalization of the functional reserve of cells and the level of proinflammatory IL-17 on day 6 of the experiment.Conclusion. The results obtained allow to verify pronounced anti-inflammatory and immunomodulatory effects of ozone and consider it as one of the most relevant treatment strategies for inflammatory bowel diseases.
Experience in the use of lung ultrasound in patients of the respiratory hospital of Siberian State Medical University with COVID-19 pneumonia
Authors: Porovskiy Ya. V. , Bespalova I. D. , Sorokina T. V. , Dish A. Ju. , Kanev A. F. , Koshchavtseva Yu. I. , Chuyashenko E. V. , Shoulga O. S. , Balabanova A. A. 
Published: April 2022

Aim. To evaluate the possibility of using lung ultrasound for diagnosing COVID-19 pneumonia in patients of the respiratory hospital of Siberian State Medical University (SSMU).Materials and methods. An analysis of lung ultrasound data was carried out in 39 patients (17 men and 22 women aged 33–78 years) with COVID-19 pneumonia. Lung ultrasound was performed in all patients in addition to radiography performed at the prehospital stage and in 15 patients who underwent computed tomography (CT) of the lungs.Results. In the majority (61.6%) of cases, during the ultrasound examination, COVID-19 pneumonia manifested itself as interstitial lung disease. The white lung phenomenon and a combination of the aforementioned interstitial changes were recorded with the same frequency (5.1%), while pulmonary consolidation in addition to interstitial changes was visualized in 10.2% of cases. Interstitial lung disease was bilateral in 83.3% of patients and unilateral in 16.7% of cases. The inferior lobes of the lungs were affected in 60.0% of cases, middle lobe – in 30.0% of cases, and superior lobes – in 15.0% of patients. The ultrasound examination detected changes in the lungs in 32 patients, while radiographic changes were present in 35 cases. Bilateral inflammation was more often detected by radiography than by ultrasound. When comparing the data of lung ultrasound and CT, the agreement between the methods was found in 66.7% of cases, and the discrepancy between the findings of the two methods was observed mainly in patients with a large number of affected segments of the lungs and localization of the disease in the superior lobes according to CT.Conclusion. Lung ultrasound is a valuable tool that can be used to stratify risk in patients at any stage of diagnosis and treatment in the context of the COVID-19 pandemic due to availability, speed of implementation, and the absence of a need for patient transportation.
FEIRA AGROECOLÓGICA DA UNIVERSIDADE FEDERAL DE MINAS GERAIS
Authors: Ramos Maurício de Lima 
Published: April 2022

O presente artigo relata como a Feira Agroecológica da Universidade Federal de Minas Gerais (UFMG) atua no processo do Sistema Participativo de Garantia (SPG) para os produtores rurais e urbanos da Região Metropolitana de Belo Horizonte (RMBH). O objetivo geral deste artigo foi de verificar se a Feira Agroecológica da UFMG está sendo uma ferramenta essencial na divulgação do SPG entre os produtores rurais e urbanos da RMBH. E os objetivos específicos de conhecer a história de envolvimento da Feira Agroecológica da UFMG com os produtores agroecológicos rurais e urbanos da RMBH e examinar os aspectos legais do SPG. Para tanto, foram realizadas pesquisas bibliográfica e documental sobre agroecologia, feira Agroecológica e SPG, com foco nos conceitos, experiências vividas e por meio de documentos oficiais, e resultados de pesquisas realizadas sobre o diagnóstico da adesão a um sistema de certificação agroecológica pelos produtores da Feira da UFMG. Constatou-se que, a Feira Agroecológica da UFMG atuou em 2019, como uma facilitadora no processo do SPG, exigindo apenas a declaração do produtor como compromisso para efetivação da sua inscrição na referida Feira, ao aceitar a participação de produtores ainda não agroecológicos no edital de seleção, na consolidação de oportunidades de transformação social, econômica e de desenvolvimento socioespacial e ambiental de agricultores familiares rurais e urbanos da RMBH.
Direct Contact Steam Generation Reduces Carbon Intensity
Authors: Kay Brian 
Published: April 2022

Abstract
Steam for enhanced oil recovery is typically generated using Once-Through-Steam-Generators (OTSG) produced at large central facilities with the steam then pipelined to each injection well. As much as 50% of the energy can be lost before it reaches the well bore with the combustion emissions vented to atmosphere.
Direct Contact Steam Generation (DCSG) injects both steam and hot combustion flue gases into the reservoir. Oil production is increased by reducing oil viscosity through heat while repressuring the reservoir with flue gases and improving miscibility with the CO2 that remains in the reservoir. This combination greatly improves the Steam-Oil-Ratio (SOR) for increased oil recovery as well as delivering environmental benefits related to reduced water requirements and lower emissions resulting in a much lower carbon intensity. DCSG water requirements are 11% less than OTSG methods as water is created by the combustion process, this water is then injected into the reservoir rather than lost to the atmosphere. As most of the DCSG process emissions are indirect, emissions can be further reduced by as much as 30% with the use of low carbon intensity grid electricity for compression.
Pilot results show that DCSG used less water, with 70% of the CO2 retained in the formation. Lower SOR and CO2 retained in the reservoir demonstrates lower carbon intensity relative to OTSG.
DCSG offers heavy oil operators a novel, viable, method to economically extract currently uncoverable reservoirs at a lower carbon intensity than traditional methods.
CO2 Foam Pilot in a Heterogeneous Carbonate Reservoir: Analysis and Results
Authors: Alcorn Zachary Paul , Graue Arne , Karakas Metin 
Published: April 2022

Abstract
A CO2 foam pilot was conducted in a heterogeneous carbonate reservoir in East Seminole Field, Permian Basin USA. The primary objective was to achieve in-depth CO2 mobility control to increase CO2 sweep efficiency and improve oil recovery in an inverted 40 acre 5-spot pattern. Foam was injected in a rapid surfactant-alternating-gas (SAG) strategy with 10 days of surfactant solution injection followed by 20 days of CO2 injection. We implemented a laboratory to field upscaling approach which included foam formulation screening, numerical modeling, and field monitoring to verify foam generation and CO2 mobility reduction. The monitoring campaign obtained baseline before the pilot and monitored reservoir response to foam injection. This included conducting baseline and pilot phase CO2 and water injection profile logs, interwell CO2 tracer tests and collecting injection bottom hole pressure data and flow rates. Transient analysis was also conducted to assess foam development at reservoir conditions. The effectiveness of foam in improving overall recovery was also evaluated.
Results indicate that foam was generated and CO2 mobility was reduced during the pilot based upon higher differential pressures during the SAG cycles compared to an identical water-alternating-gas (WAG) cycle. CO2 breakthrough was also delayed with foam compared to the baseline test without foam. Injection profile logs from the foam injector showed that flow increased into unswept reservoir intervals and was diverted from a high permeability streak. The effectiveness of foam in improving the overall oil recovery revealed that the foam pilot produced 30% more oil than the pattern's projected performance without foam, despite injecting at half of the historical rate during the pilot. This work presents the complete field results and analysis from the successful implementation of CO2 foam mobility control.
SmartWater Based Synergistic Technologies: A Next Recovery Frontier for Enhanced Oil Recovery
Authors: Ayirala Subhash C. , AlSofi Abdulkareem M. , AlYousef Zuhair A. , Wang Jinxun , Alsaud Moataz O. Abu , AlYousef Ali A. 
Published: April 2022

Abstract
In this work, the synergistic effects of SmartWater in polymer flooding, surfactant-polymer flooding, carbonated waterflooding, and foam assisted gas injection processes were explored. A suite of multiscale experimental data was analyzed to demonstrate and quantify the benefits of water chemistry synergies in these different enhanced oil recovery (EOR) methods. The multiscale experimental data analyzed comprised of polymer rheology, core floods, foam stability and rheology, besides evaluating the zeta potential results obtained from surface complexation modeling (SCM).
SmartWater increased the oil recoveries by 5-7% in addition to reducing the polymer concentration requirements by one-third in polymer flooding. Synergizing SmartWater with surfactant-polymer flooding increased the oil recovery by 4% besides lowering the polymer and surfactant consumption by 50%. SmartWater has been found to synergistically combine with carbonated waterflooding to increase the CO2 dissolved volumes by 25-30% for effectively lowering the pH at both calcite/brine and crude oil/brine interfaces. The availability of more CO2 dissolved volumes in SmartWater can cause enhanced oil swelling, greater oil viscosity reduction, and increased wettability alteration through pH induced modification of surface charges for higher oil recovery. SmartWater increased the foam stabilities by 2-3 times, foam apparent viscosities by 1.5 times, and porous media foam pressure drops by 50% to ensure the propagation of more stable and viscous foams deeper into the reservoir for better mobility control.
The findings of this study have a practical impact on how the industry can efficiently operate EOR projects. SmartWater-based synergistic technologies can reduce the costs due to lowered volume requirements of different EOR agents and they can also increase oil recoveries to result in more practical, efficient, and economical EOR projects in the field.
Towards More Representative Workflows for Designing Robust Surfactant EOR Formulations
Authors: Wartenberg Nicolas , Blaizot Dylan , Mascle Matthieu , Mouret Aurélie , Rousseau David 
Published: April 2022

Abstract
Designing robust EOR surfactant formulations implies performing a number of experiments related to the impact of variable parameters such as injection brine composition and reservoir temperature from near wellbore to in-depth zones. Performance evaluation assays are commonly employed in parametric studies, ahead of the time-consuming coreflood tests. Phase diagram in tubes and spinning drop tests are commonly used, but they do not easily allow deriving representative values of the o/w IFT and can lead to contradictory outcomes.
In this work, we addressed the crucial question of the methods implemented to estimate the IFT in bulk tests and we investigated a model case where the robustness of a surfactant formulation was assessed versus temperature. In the first part, we compared, at optimal salinity, the IFT as classically evaluated by the Huh relationship in tubes to the IFT as determined in a spinning drop tensiometer between, respectively, the microemulsion and the water and oil phases in equilibrated and non-equilibrated situations. In the second part, we evaluated the robustness of a surfactant formulation in terms of IFT versus temperature variation by phase diagrams and spinning drop methods and performed simplified oil recovery coreflood tests, using the CAL-X high throughput device.
Results showed that IFT discrepancies up to one order of magnitude exist between the Huh estimation and the spinning drop results as well as between the different strategies for determining the spinning drop IFT. Such discrepancies can be interpreted from a scientific point of view, but they highlight the need to discriminate between the IFT determination methods in view of representativeness regarding the actual oil recovery mechanisms in the reservoir. The tests campaign for the temperature robustness, performed in the 40-90°C temperature range, showed, again, discrepancies between the two bulk methods. Namely, Winsor III situation was observed from 60°C to 90°C in the phase diagrams with an optimum at 70°C whereas ultra-low IFT was observed only at 60°C in the spinning drop tests. The coreflood tests revealed that very good oil recoveries were achieved from 40°C to 90°C, with evidence of formation of oil banks leading to final oil saturation as low as 5% only from 60°C to 90°C.
These outcomes suggest that, for cases where the various phases are clearly distinguishable in tubes, phase diagrams should be selected as preferred bulk assays. However, these tests provide only coarse estimates of the IFT, which makes performance prediction based on capillary desaturation curves challenging. For this reason, high throughput coreflood tests could also be included in surfactant formulation design workflows to better forecast for the formulation performances.
Modeling of Laboratory Gas Flooding in Tight Chalk with Different Non-Equilibrium Treatments
Authors: Mirazimi Seyedamir , Olsen Dan , Stenby Erling Halfdan , Yan Wei 
Published: April 2022

Abstract
This paper focuses on proper modeling of bypassed oil in tight chalk during gas injection, caused partly by the small-scale heterogeneity and the non-equilibrium contact especially in low permeable chalk. Conventional compositional simulators using the local equilibrium assumption tend to predict excessive vaporization of the residual oil. We present the laboratory gas flooding results in tight chalk and discuss how different non-equilibrium treatments can provide more realistic simulation results.
Composite core flooding experiments with low-permeable tight chalk and natural gas were conducted at different pressures below the minimum miscibility pressure of the live oil used. The ECLIPSE compositional simulator E300, using an EoS model tuned with the swelling data, was used to history match the results. It was found that the simulation without considering non-equilibrium effects over-predicted the oil production in the late stage. Two methods were tested to avoid the excessive vaporization of oil: the Sorm method (excluding the residual oil from flash calculations) and the transport coefficients (alpha factors) method together with pseudo-relative permeability curves.
Our results show that the sub-grid non-equilibrium effect is significant in tight chalk. Compositional simulation without considering this effect leads to unrestricted vaporization and over-prediction of the oil recovery in gas injection into tight chalk even for laboratory experiments. Both methods tested here are suitable for reproducing the flooding results, in particular, the residual oil in the late stage. For the experiments studied here, the Sorm method seems to show a better performance in maintaining no further mass transfer between the residual oil and gas after the ultimate recovery is reached, since it excludes the bypassed oil fraction from flash calculations and models the immobile saturation explicitly. For the alpha factors method, oil production keeps a slow increase at the late stage as long as gas is being injected. In addition, the use of pseudo-relative permeability method can lead to obtaining irrational trends in some cases. We therefore propose an alternative method by adjusting the alpha factors of the mobile components, which avoids the difficulties of modifying the relative permeability curves.
This study contributes to the methodology on honoring the non-equilibrium effects and obtaining realistic residual oil saturation for gas injection in tight formation. The proposed method of adjusting the non-zero alpha factors can be used as an alternative to using pseudo-relative permeability, which avoids the possible drawbacks involved in this method.
Interference Analysis in Reservoirs with Bottom-Water Drive During Water Injection Processes Through Subsurface Connectivity
Authors: Martinez Vladimir , Ozkan Erdal , Cinco Ley Heber 
Published: April 2022

Abstract
This work analyzes the feasibility of implementing water injection processes through subsurface connectivity between different formations through communicating wells, allowing the water to flow from a source aquifer to a depleted formation. It presents a 3-dimensional semi-analytical model for estimating water influx in reservoirs with bottom-water drive and analyzing interference between reservoirs when subsurface connectivity is carried out to supply energy from an aquifer. It applies to both finite and infinite aquifers and reservoirs sharing an aquifer. The general solution is obtained by solving the diffusion equation employing Laplace and Fourier cosine transforms and is presented in Laplace space, requiring a numerical inversion method to convert the results to the real space. The functionality of the analytical solution is evaluated with reservoir numerical simulation and communicating well models. Results show that implementing this solution brings notable advantages because the ultimate oil recovery factor improves considerably. Additionally, it delays the water encroachment in reservoirs adjoined to the source aquifer and reduces water production.