bluuebunny/crossref_metadata_2025_split huggingface dataset:
Alpha-band power increases in posterior brain regions in attention deficit hyperactivity disorder after digital cognitive stimulation treatment: randomized controlled study
Authors: de Ramón Ignacio , Pacios Javier , Medina Rafael , Bouhaben Jaime , Cuesta Pablo , Antón-Toro Luis , Quintero Javier , Quiroga Antoni Ramos , Maestú Fernando 
Published: February 2022

AbstractThe changes triggered by pharmacological treatments in resting-state alpha-band (8–14 Hz) oscillations have been widely studied in attention deficit hyperactivity disorder. However, to date, there has been no evidence regarding the possible changes in cognitive stimulation treatments on these oscillations. This paper sets out to verify whether cognitive stimulation treatments based on progressive increases in cognitive load can be effective in triggering changes in alpha-band power in attention deficit hyperactivity disorder. With this objective, we compared a cognitive stimulation treatment (n = 12) to a placebo treatment (n = 14) for 12 weeks (36 sessions of 15 min) in child patients (8–11 years old) with attention deficit hyperactivity disorder. Two magnetoencephalographic recordings were acquired for all participants. In order to extract the areas with changes in alpha power between both magnetoencephalographic recordings, the differences in the power ratio (pre/post-condition) were calculated using an analysis of covariance test adjusted for the age variable. The results show an increase in the post-treatment alpha power in the experimental group versus the placebo group (P &lt; 0.01) in posterior regions. In addition, these changes were related to measures of attention, working memory and flexibility. The results seem to indicate that cognitive stimulation treatment based on progressive increases in cognitive load triggers alpha-band power changes in children diagnosed with attention deficit hyperactivity disorder in the direction of their peers without this disorder.
Syndapin-2 mediated transcytosis of amyloid-β across the blood–brain barrier
Authors: M. Leite Diana , Seifi Mohsen , Ruiz-Perez Lorena , Nguemo Filomain , Plomann Markus , Swinny Jerome D. , Battaglia Giuseppe 
Published: February 2022

Abstract
A deficient transport of amyloid-β across the blood–brain barrier, and its diminished clearance from the brain, contribute to neurodegenerative and vascular pathologies, such as Alzheimer’s disease and cerebral amyloid angiopathy, respectively. At the blood–brain barrier, amyloid-β efflux transport is associated with the low-density lipoprotein receptor-related protein 1. However, the precise mechanisms governing amyloid-β transport across the blood–brain barrier, in health and disease, remain to be fully understood. Recent evidence indicates that the low-density lipoprotein receptor-related protein 1 transcytosis occurs through a tubulation-mediated mechanism stabilized by syndapin-2. Here, we show that syndapin-2 is associated with amyloid-β clearance via low-density lipoprotein receptor-related protein 1 across the blood–brain barrier. We further demonstrate that risk factors for Alzheimer’s disease, amyloid-β expression and ageing, are associated with a decline in the native expression of syndapin-2 within the brain endothelium. Our data reveals that syndapin-2-mediated pathway, and its balance with the endosomal sorting, are important for amyloid-β clearance proposing a measure to evaluate Alzheimer’s disease and ageing, as well as a target for counteracting amyloid-β build-up. Moreover, we provide evidence for the impact of the avidity of amyloid-β assemblies in their trafficking across the brain endothelium and in low-density lipoprotein receptor-related protein 1 expression levels, which may affect the overall clearance of amyloid-β across the blood–brain barrier.
‘Egg-cased heart’: a multimodality imaging approach to chronic constrictive pericarditis with egg-shell calcification: a case report
Authors: Sane Pratik Sudhir , Sankardas Ajit Mullasari , Bhardwaj Kambarnatham Srinivasan , Kurian and Valikapathalil Mathew 
Published: February 2022

Abstract

Background
Constrictive pericarditis (CP), also known as Pick’s disease, is a sequela of chronic inflammation of the pericardium. Pericardial calcification is a common occurrence in CP; however, extensive egg-shell like calcification is rare. Our case, highlights, how a multi-modality imaging in a middle aged female helped to diagnose chronic constrictive pericarditis (CCP) with egg-shell like calcification encasing the heart.

Case summary
Middle aged female with features of right heart failure, was diagnosed as CP based on two-dimensional echocardiography and cardiac catheterization. Computed tomography (CT) scan chest showed extensive egg-shell like calcification encasing the heart, suggestive of calcific CP. Subsequently, she underwent pericardiectomy, through median sternotomy approach and is currently on follow-up with asymptomatic cardiac status.

Discussion
Extensive pericardial calcification encasing the heart like an egg-shell is rare in CCP. Likelihood of incomplete pericardial resection is high in calcific CP and hence a median sternotomy is preferred over anterolateral thoracotomy. A preoperative non-contrast CT scan defines the thickness, anatomic extent the calcification and its adherence to myocardium and surrounding structures. A reconstructed volume-rendered image delineates the extent of calcification precisely, thus determining the optimum surgical approach. A multi-modality imaging in CP, especially in calcific CP, is thus of paramount importance.
Severe sphincter of Oddi spasm after cryoballoon ablation: a case report of an unusual complication after atrial fibrillation ablation
Authors: Hayashi Yusuke , Shimeno Kenji , Tamura Shota , Naruko Takahiko 
Published: February 2022

Abstract

Background
Perioesophageal vagal nerve (VN) injury after atrial fibrillation (AF) ablation remains an important complication. The VN provides parasympathetic innervation to the majority of the abdominal organs—including the stomach and the sphincter of Oddi (SO)—and regulates smooth muscle contraction. We present an unusual case of SO spasm induced by VN injury after cryoballoon ablation (CBA).

Case summary
A 71-year-old woman presented to our institution with paroxysmal AF. The patient had a history of cholecystectomy and SO dysfunction. She had undergone CBA for AF. Immediately after the procedure, the patient developed epigastric pain. Computed tomography showed dilation of the intra- and extrahepatic bile ducts, with the diameter of the common bile duct measuring ∼15.6 mm. Blood tests on postoperative Day 1 revealed severely elevated aminotransferase levels (aspartate aminotransferase, 3156 U/L; alanine aminotransferase, 2084 U/L; lactate dehydrogenase, 2279 U/L; total bilirubin 1.7 mg/dL).

Discussion
It is known that VN denervation induces SO spasms. The right and left vagal trunks descend alongside the oesophagus, forming a perioesophageal plexus and innervating most of the gastrointestinal organs. In our case, SO spasm was induced as a result of the perioesophageal plexus injury caused by CBA. Underlying SO dysfunction and post-cholecystectomy also played an important role. Coupled with the absence of the gallbladder, which is the reservoir of bile juice and coordinator of SO, SO spasm caused severe elevation of the bile duct pressure. Care should be taken when performing AF ablation with regards to the stomach and the SO.
Capacity building in European health information systems: the InfAct peer assessment methodology
Authors: Bogaert Petronille , Verschuuren Marieke , Van Oyen Herman , van Oers Hans 
Published: February 2022

Abstract

Background
A Health Information System (HIS) assessment is an evaluation of the functioning of the main elements that compose a national HIS. Assessors from nine countries performed peer assessments of each other’s national HIS in the Joint Action on Health Information (InfAct). The aim of this study is to evaluate the advantages and disadvantages of the InfAct peer assessment methodology as well as the different steps involved in this assessment process.

Methods
Each peer assessment included a preparatory desk report, a country visit with semi-structured interviews with local stakeholders, a final report and a follow-up stakeholder meeting. A qualitative content analysis of the peer HIS assessment was performed based on 12 semi-structured interviews.

Results
The main advantage of the assessments is its informal atmosphere, high degree of objectiveness and its networking opportunities. Disadvantages are its informal request format and setting for recommendation uptake. The peer assessment helped the assessors to broaden their understanding of the assessed and their own HISs, to gain knowledge on how to carry out an HIS assessment and to practice their organization, communication, reporting and negotiation skills. All steps of the HIS assessment are essential and each contributes to the enriching experience of the participants.

Conclusion
The InfAct peer HIS assessment methodology strengthened capacity in national HISs by building up the knowledge and expertise in participating countries and as such addressed health information inequalities. This study confirms the value and relatively easy to implement methodology, and therefore recommends its wide and more systematic application across Europe.
Effect of high shear homogenization on quality characteristics of bael fruit pulp
Authors: Kamble Meenatai G , Singh Anurag , Kumar Prabhakar Pramod , Meghwal Murlidhar , Veer Singh Sukh , Chinchkar Ajay V 
Published: February 2022

Abstract
Response surface methodology was used to investigate the influence of high shear homogenization speed (A: 3000–12 000 r/min) and processing time (B: 30–120 min) on bael fruit pulp quality parameters. The experimental results were best fitted in the suggested quadratic model to delineate and envision the responses in terms of color (values of L*, meaning brightness to blackness, 100–0; a*, meaning green –a* to red +a*; and b*, meaning blue –b* to yellow +b), total soluble solids, ascorbic acid, viscosity, and β-carotene content with the highest coefficients of determination (R2) ranging from 0.80 to 0.99. Significant (P&lt;0.05) change in the L* value, total soluble solids, ascorbic acid, and β-carotene content was found with change in homogenization speed. The interaction effect of homogenization showed a significant difference in a* value and total soluble solid content of the pulp. The best homogenization conditions were determined via multiple response optimization as 10 682 r/min speed and 43.18 min process time. The quality parameters of the pulp at optimized conditions were observed as L* 15.35, a* 4.51, b* 10.25, ascorbic acid 18.64 mg/100 g, viscosity 5349 cP, and β-carotene 4.14 μg/100 g. In addition, total phenolic content, flavonoid content, and antioxidant content of homogenized bael fruit pulp was found to significantly (P&lt;0.05) increase from (83.76±1.24) to (119.21±1.35) mg gallic acid equivalent (GAE)/100 mL, (147.39±0.69) to (156.10±1.11) mg quercetin equivalent (QE)/100 mL, and (41.77%±0.60%) to (66.53%±0.41%), respectively. Consequently, this strategy could be used in fruit processing industries to process highly fibrous fruits and nonuniform-textured fruit pulp to avoid sedimentation while retaining functionality.
A-to-I mRNA editing controls spore death induced by a fungal meiotic drive gene in homologous and heterologous expression systems
Authors: Lohmar Jessica M , Rhoades Nicholas A , Patel Tejas N , Proctor Robert H , Hammond Thomas M , Brown Daren W 
Published: February 2022

Abstract
Spore killers are meiotic drive elements that can block the development of sexual spores in fungi. In the maize ear rot and mycotoxin-producing fungus Fusarium verticillioides, a spore killer called SkK has been mapped to a 102-kb interval of chromosome V. Here, we show that a gene within this interval, SKC1, is required for SkK-mediated spore killing and meiotic drive. We also demonstrate that SKC1 is associated with at least 4 transcripts, 2 sense (sense-SKC1a and sense-SKC1b) and 2 antisense (antisense-SKC1a and antisense-SKC1b). Both antisense SKC1 transcripts lack obvious protein-coding sequences and thus appear to be noncoding RNAs. In contrast, sense-SKC1a is a protein-coding transcript that undergoes A-to-I editing to sense-SKC1b in sexual tissue. Translation of sense-SKC1a produces a 70-amino-acid protein (Skc1a), whereas the translation of sense-SKC1b produces an 84-amino-acid protein (Skc1b). Heterologous expression analysis of SKC1 transcripts shows that sense-SKC1a also undergoes A-to-I editing to sense-SKC1b during the Neurospora crassa sexual cycle. Site-directed mutagenesis studies indicate that Skc1b is responsible for spore killing in Fusarium verticillioides and that it induces most meiotic cells to die in Neurospora crassa. Finally, we report that SKC1 homologs are present in over 20 Fusarium species. Overall, our results demonstrate that fungal meiotic drive elements like SKC1 can influence the outcome of meiosis by hijacking a cell’s A-to-I editing machinery and that the involvement of A-to-I editing in a fungal meiotic drive system does not preclude its horizontal transfer to a distantly related species.
Bayesian-based joint determination of earthquake hypocentres and 1-D velocity structures divided by a structural boundary
Authors: Shiina Takahiro , Kano Masayuki 
Published: February 2022

SUMMARY
We propose a Bayesian approach for jointly determining the locations of earthquake hypocentres and velocity structures in a region divided by a structural boundary, such as a fault zone. To accommodate the Markov chain Monte Carlo (MCMC) method in a region containing lateral velocity contrast, we incorporated a data-driven station clustering scheme when estimating earthquake hypocentre locations, a 1-D velocity model assigned to each cluster and station corrections for traveltimes. The proposed method realizes the clustering of stations reflecting velocity structures beneath the station network in the framework of the MCMC method. We verified the performances of the proposed method using numerical experiments with different distributions of earthquake hypocentres relative to the structural boundary. The results demonstrated that the proposed method reconstructed earthquake hypocentre locations and velocity structures involving lateral contrast robustly to earthquake distributions. Additionally, the number of 1-D velocity models (the number of station clusters) was optimized by comparing resultant posterior probability proportional to distances between the observed and theoretical traveltimes. We also applied the proposed method to estimate the earthquake hypocentre locations and velocity structures around the source area of the 2004 Mid-Niigata prefecture earthquake, Japan, to examine the applicability of the proposed method to real observation data. The stations were divided into east and west clusters, coinciding with the lateral velocity variation related to the geological setting. Therefore, the proposed method accurately determines earthquake hypocentres in a region divided by a structural boundary without any knowledge regarding the geological structure.
Sarcopenia Is More Prevalent Among Inflammatory Bowel Disease Patients Undergoing Surgery and Predicts Progression to Surgery Among Medically Treated Patients
Authors: Campbell James P , Teigen Levi , Manski Scott , Blumhof Brian , Guglielmo Flavius F , Shivashankar Raina , Shmidt Eugenia 
Published: February 2022

Abstract

Background
Sarcopenia is common in inflammatory bowel disease (IBD); however, estimates of its prevalence and impact on clinical outcomes are variable. This study sought to compare the prevalence of sarcopenia in IBD patients starting new biologics vs patients undergoing IBD surgeries, and its association with common clinical predictors of nutritional status, adverse events, and clinical outcomes.

Methods
This was a multicenter retrospective cohort study of IBD patients who had a computed tomography (CT) scan within 6 months prior to new biologic initiation (medical cohort) or IBD surgery (surgery cohort). The lowest sex-specific quartile of the total psoas area index at the L3 level defined sarcopenia. Prevalence and predictors of sarcopenia, performance of common clinical nutritional markers, and association with adverse events and clinical outcomes at 1 year were determined.

Results
A total of 156 patients were included (48% medical cohort, 52% surgery cohort). Sarcopenia was more common in the surgery cohort (32% vs 16%; P &lt; .02). In the medical cohort, sarcopenia predicted need for surgery at 1 year (odds ratio, 4.75; 95% confidence interval, 1.10-20.57; P = .04). Low albumin and body mass index (BMI) were associated with the presence of sarcopenia; however, 24% of sarcopenic patients had both normal BMI and albumin.

Conclusions
Sarcopenia is more prevalent among IBD patients undergoing surgery and predicts the need for surgery in patients starting new biologic therapy. Low albumin and BMI were similar between cohorts, suggesting a unique role for sarcopenia as a relevant clinical marker of lean muscle mass depletion for surgically and medically treated IBD patients.
The effect of enriched accreted matter on the development of novae
Authors: Hillman Yael , Gerbi Maya 
Published: February 2022

ABSTRACT
The development of a nova eruption is well known to be determined by the white dwarf (WD) mass and the rate at which it accretes mass from its donor. One of the advancements in this field is the understanding that the occurrence of a nova eruption depends on the presence of heavy elements in the envelope, and that the concentration of these elements is highly dependent on the time allotted for accretion. This results in many features of the eruption being correlated with the mass fractions of heavy elements in the ejected material, however, the accreted material is always assumed to be of solar metallicity. Here, we explored the entire range of accretion rates on to a 1.25 $\, \mathrm{M}_\odot$ WD for two cases of highly enriched accreted material and find enrichment to have an influence on certain features for high accretion rates, while the effect of enrichment on low accretion rates is negligible. We further find that the ignition of the thermonuclear runaway which is known to be dependent on the accumulation of a critical mass, is actually dependent on the accumulation of a critical amount of heavy elements.
Superinduction of immunosuppressive glioblastoma extracellular vesicles by IFN-γ through PD-L1 and IDO1
Authors: Jung Mi-Yeon , Aibaidula Abudumijiti , Brown Desmond A , Himes Benjamin T , Cumba Garcia Luz M , Parney Ian F 
Published: February 2022

Abstract

Background
Glioblastoma (GBM), the most common primary brain tumor, has a median survival of 15–16 months. Immunotherapy is promising but GBM-mediated immunosuppression remains a barrier. GBMs express the interferon-gamma (IFN-γ)-responsive immunosuppressive molecules programmed cell death ligand 1 (PD-L1) and indoleamine 2,3-dioxygenase 1 (IDO1). Extracellular vesicles (EVs) have also been implicated in GBM-mediated immunosuppression, in part through PD-L1. We therefore sought to determine if GBM IFN-γ exposure increased GBM EV-mediated immunosuppression and mechanisms underlying this.

Methods
Human GBM-derived cells were cultured in the presence/absence of IFN-γ. EVs were harvested. PD-L1, IDO1, and EV-associated protein expression was assessed. GBM EVs (+/−IFN-γ) were cultured with healthy donor monocytes. Immunosuppressive myeloid-derived suppressor cell (MDSC) and nonclassical monocyte (NCM) frequency was determined. Impact of GBM (+/−IFN-γ) EV-treated monocytes on CD3/CD28-mediated T cell proliferation was assessed. The impact of PD-L1 and IDO1 knockdown in GBM EVs in this system was evaluated.

Results
IFN-γ exposure increased PD-L1 and IDO1 expression in GBM cells and EVs without altering EV size or frequency. IFN-γ-exposed GBM EVs induced more MDSC and NCM differentiation in monocytes and these monocytes caused more T cell inhibition than IFN-γ-naive GBM EVs. PD-L1 and/or IDO1 knockdown in GBM cells abrogated the immunosuppressive effects of IFN-γ-exposed GBM EVs on monocytes.

Conclusions
IFN-γ exposure such as might occur during an antitumor immune response results in superinduction of GBM EVs’ baseline immunosuppressive effects on monocytes. These effects are mediated by increased PD-L1 and IDO1 expression in GBM EVs. These data highlight mechanisms of GBM EV-mediated immunosuppression and identify therapeutic targets (PD-L1, IDO1) to reverse these effects.
Intraventricular Plus Systemic Antibiotic Therapy for Treating Polymyxin-Resistant Klebsiella pneumoniae Ventriculitis: A Case Report
Authors: Wang Hao , Zhou Qian , Huang Kaiyuan , Yang Xiaofeng , Wen Liang 
Published: February 2022

Abstract

Background
Treating central nervous system (CNS) infections caused by extensively drug-resistant (XDR) gram-negative bacilli, such as carbapenem-resistant Klebsiella pneumoniae, represents a significant clinical challenge. Polymyxin is occasionally used as a salvage treatment for this severe CNS infection. We report here a rare case of polymyxin-resistant Klebsiella pneumoniae ventriculitis, which was successfully treated with ventricular injections and intravenous antibiotics.

Methods
A 53-year-old male underwent a decompressive craniectomy and was referred to our hospital with cerebrospinal fluid incisional leakage and persistent fever.

Results
The minimum inhibitory concentration of polymyxin B in this patient increased from 2 to 4 μg/mL during the course of treatment. He was diagnosed with polymyxin-resistant XDR Klebsiella pneumoniae ventriculitis. We successfully treated the infection with intravenous ceftazidime/avibactam (CAZ/AVI) combined with ventricular injection of tigecycline according to cerebrospinal fluid microbiological culture.

Conclusions
CAZ/AVI combined with tigecycline may be an effective salvage treatment for CNS infections caused by polymyxin-resistant XDR Klebsiella pneumoniae.