bluuebunny/crossref_metadata_2025_split huggingface dataset:
Treatment of infantile fibrosarcoma: A tertiary care center experience
Authors: Han Yidi , Lian Kai , Zhang Dongdong 
Published: November 2022

ObjectiveInfantile fibrosarcoma (IFS) is a highly locally aggressive nonrhabdomyosarcomatous soft tissue sarcoma that most commonly occurs in young infants. There exists no standard treatment this lesion due to its rarity. We shared our treatment experience for IFS in this study.MethodsPatients' record between January 2013 and December 2018 were reviewed and patients with newly diagnosed IFS were included. The clinical characteristics, treatment strategy, treatment-related toxicities and clinical outcome were retrospectively analyzed.ResultsEleven patients were admitted in our center, including 4 girls and 7 boys, and the median age at diagnosis was 5 months (range 1–23 months). Ten patients achieved complete remission (CR) after the completion of initial treatment. The main short-term adverse effects was myelosuppression. Three patients experienced relapse, including two patients with local progression and one patient with distant metastasis. After a median follow-up of 3.5 years (range 1.5–7 years), 9 patients were alive and 2 patients died. The 3-year overall survival (OS) rate was 93.5% (95% CI 83.7–98.2).ConclusionWe formulated the treatment strategy according to group grade and the experience from previous studies, which may be effective and feasible for the treatment of IFS.
Gynecomastia: A systematic review of pharmacological treatments
Authors: Berger Ori , Landau Zohar , Talisman Ran 
Published: November 2022

BackgroundPubertal gynecomastia (PG), a benign condition with varied reported prevalence, typically appears at 13–14 years-old and is mostly idiopathic and self-limited. Psychologic impairments are common among adolescents with gynecomastia. Surgical intervention is reserved to severe cases and is offered towards the end of puberty. Pharmacological treatment is seldom given by clinicians mainly due to insufficient published data. We conducted this systematic literature review to assess the efficacy, safety, side effects, and complications of pharmacological treatments published.MethodsMEDLINE, Embase, and Cochrane CENTRAL were searched for the terms “gynecomastia”, “pubertal”, and “adolescent” in conjunction with medications from the Selective Estrogen Receptor Modulator (SERM), aromatase inhibitors (AI), and androgens groups in different combinations to optimize the search results. Exclusion criteria included: studies based on expert opinion, similar evidence-based medicine levels studies, and studies which discuss gynecomastia in adults. Selected articles were assessed by two authors. Data collected included: the level of evidence, population size, treatment regimen, follow-up, outcomes, complications, and side effects.ResultsOf 1,425 published studies found and examined meticulously by the authors, only 24 publications met all the study research goals. These were divided into 16 publications of patients treated with SERM, of whom four had AI and four androgens. In general, the data regarding pharmacologic therapy for PG is partial, with insufficient evidence-based research. Tamoxifen and SERM drugs have long been used as treatments for PG. Tamoxifen was the chosen drug of treatment in most of the reviewed studies and found to be effective, safe, and with minimal side effects.ConclusionsPharmacological treatment as a new standard of care has an advantage in relieving behavioral and psychological distress. Although high quality publications are lacking, pharmacological intervention with tamoxifen is appropriate in select patients. Conduction large-scale high-quality studies are warranted with various drugs.
Daytime napping, comorbidity profiles, and the risk of sarcopenia in older individuals
Authors: Hu Zhigang , Yang Ailan , Tian Yufeng , Song Xinyu 
Published: November 2022

Appropriate daytime napping is associated with the decreased risk of cerebro-cardiovascular diseases, but whether daytime napping affects sarcopenia remains to be explored. Our study plans to examine the associations between sarcopenia with daytime napping and comorbidity. The study population came from the China Health and Retirement Longitudinal Study 2011–2015. Latent class analysis (LCA) was used to identify comorbidity profiles based on 14 doctor-diagnosed chronic diseases. Subsequently, smooth function and restricted cubic spline with three binomial regression models determined the associations between sarcopenia with daytime napping and comorbidity profiles. About 18.7% (2,894) and 5.4% (832) of 15,404 individuals were diagnosed with sarcopenia and severe sarcopenia. LCA delineated four classes as the best fit as follows: dominant heart diseases or risks (class 1, N = 2,203), dominant chronic lung diseases (class 2, N = 740), minimal or least diseases (class 3, N = 10,612, reference), and dominant digestive diseases and rheumatism (class 4, N = 1849). Compared with the reference group (class 3), the multivariate-adjusted ORs (95% CIs) of sarcopenia in model 3 were 0.72 (0.60–0.88) for class 1, 1.17 (0.92–1.51) for class 2, and 0.92 (0.77–1.09) for class 4. Smooth function and restricted cubic spline suggested that individuals who napped about 60 min seemingly had the lowest risk of sarcopenia. Individuals who napped for 1–59 min (adjusted OR = 0.80, 95% CI: 0.68–0.94) and 60–119 min (adjusted OR = 0.83, 95% CI: 0.72–0.95) had the significantly lower risk of sarcopenia but not severe sarcopenia than those who did not nap. Insufficient and excessive daytime napping might be associated with the increased risk of sarcopenia, especially in individuals with a dominant chronic lung disease profile.
Constant installation of present orientation and safety (CIPOS) - subjective and physiological effects of an ultrashort-term intervention combining both stabilizing and confrontational elements
Authors: Stingl Markus , Sammer Gebhard , Hanewald Bernd , Zinsser Franziska , Tucha Oliver , Pape Valeska Reichel 
Published: November 2022

ObjectivesConstant Installation of Present Orientation and Safety (CIPOS) is a Eye Movements Desensitization and Reprocessing (EMDR)-derived technique, which is often used to prepare for the treatment of post-traumatic stress disorder (PTSD). It differs from the latter by involving cyclically recurring exercises in reorientation to the present, interspersed between brief periods of exposure to the traumatic material.While EMDR is well established as a therapeutic method, the efficacy and mechanisms of action of CIPOS have not been investigated so far. In this pilot study, an experimental setting was used to record the subjective and physiological effects of the CIPOS intervention compared to a control condition with pure mental exposition.MethodsThe study was performed on 30 healthy volunteers aged from 20 to 30 years. Distress was induced using audio files of subjectively stressful situations. Subjective distress was measured via the Subjective Units of Distress Scale (SUD), while physiological indicators (noise-induced startle reflex, skin conductance level) were used as measures for objective stress. For each condition, pre- and post-intervention comparisons were calculated.ResultsIn both groups, startle reflex potentiation and mean skin conductance level significantly decreased. In the group with CIPOS intervention, but not in the control group, a significant decrease in the SUD value was found.Conclusion and significanceThe results show that the CIPOS technique is as effective as pure mental exposition in reducing physiological stress. In addition, a superiority in reducing subjective distress (indicating a simplified reassessment of the stressful material) was found compared to pure mental exposition. Possible explanations of these effects are discussed.
Maternal choices and preferences for screening strategies of gestational diabetes mellitus: A exploratory study using discrete choice experiment
Authors: Xu Tingting , Jiang Yan , Guo Xiuyan , Campbell Julie A. , Ahmad Hasnat , Xia Qing , Lai Xiaozhen , Yan Di , Ma Liangkun , Fang Hai , Palmer Andrew J. 
Published: November 2022

AimsThis study aimed to investigate maternal preferences for gestational diabetes mellitus (GDM) screening options in rural China to identify an optimal GDM screening strategy.MethodsPregnant women at 24–28 gestational weeks were recruited from Shandong province, China. A discrete choice experiment (DCE) was conducted to elicit pregnant women's preferences for GDM screening strategy defined by five attributes: number of blood draws, out-of-pocket costs, screening waiting-time, number of hospital visits, and positive diagnosis rate. A mixed logistic model was employed to quantify maternal preferences, and to estimate the relative importance of included attributes in determining pregnant women's preferences for two routinely applied screening strategies (“one-step”: 75 g oral glucose tolerance test [OGTT] and “two-step”: 50 g glucose challenge-test plus 75 g OGTT). Preference heterogeneity was also investigated.ResultsN = 287 participants completed the DCE survey. All five predefined attributes were associated with pregnant women's preferences. Diagnostic rate was the most influential attribute (17.5 vs. 8.0%, OR: 2.89; 95%CI: 2.10 to 3.96). When changes of the attributes of “two-step” to “one-step” strategies, women's uptake probability from full “two-step” to “one-step” significantly increased with 71.3% (95%CI: 52.2 to 90.1%), but no significant difference with the first step of “two-step” (−31.0%, 95%CI: −70.2 to 8.1%).ConclusionChinese pregnant women preferred the “one-step” screening strategy to the full “two-step” strategy, but were indifferent between “one-step” and the first step of “two-step” strategies.
Physical activity and sport-specific training patterns in Swedish sporting and working trial dogs—A questionnaire survey
Authors: Essner Ann , Hesbach Amie L. , Igelström Helena , Kjellerstedt Catarina , Svensson Kristina , Westerlind Helga 
Published: November 2022

ObjectiveTo explore physical activity patterns, including conditioning exercise and sport-specific training, and management routines utilized by handlers of Swedish sporting and working dogs participating in agility, obedience, rally obedience and working trial disciplines.ProceduresDog handlers provided information on competition-level dogs through an internet-based cross-sectional and descriptive survey on physical activity, sport-specific training and management. Results are reported overall and stratified by participation in specific disciplines.ResultsWe received 1615 replies to the questionnaire. After data cleaning, 1582 dogs (98%) remained for the analysis. Of these, 430 participated in agility, 790 in obedience, 596 in rally obedience, and 847 dogs had competed in a working trial, i.e., messenger, protection, search or tracking. Number of disciplines performed by each dog varied between one and five. Most common was participation in one (n = 767, 48%) or two (n = 541, 34%) disciplines. Out of the dogs competing in one discipline, 38% (n = 294) were considered to be specialized as they actively trained only that discipline for ≥10 months per year. The vast majority of the dogs (n = 1129, 71%) received more than 1 h of daily physical activity, e.g., walks, and only n = 51 (3%) were never exercised off-leash. Preferred self-selected gait was trot (n = 907, 57%) and gallop (n = 499, 32%). A fifth (n = 319, 20%) never played with other dogs. The majority (n = 1328, 84%) received more than 1 h of vigorous physical conditioning exercise per week. Almost three quarters (n = 1119, 71%) participated in physical conditioning exercise. Two thirds (n = 953, 60%) participated in at least 3 h of sport-specific training per week and only a very small portion (n = 35, 2%) trained their specific discipline less than once per week. Median total work load, i.e., all daily physical activity, vigorous physical conditioning exercise and sport-specific training, was 16.5 h per week.Conclusion and clinical relevanceWe observe physical activity at moderate to high durations and moderate to vigorous intensities among Swedish sporting and working trial dogs. Most dogs received physical conditioning exercise, but not all dogs were warmed up before training and competition. Our study provides veterinary professionals and dog trainers with valuable insights on the physical exposures and management routines of sporting and working trial dogs.
RNA-Seq and Iso-Seq Reveal the Important Role of COMT and CCoAOMT Genes in Accumulation of Scopoletin in Noni (Morinda citrifolia)
Authors: Jia Dandan , Jin Can , Gong Shusen , Wang Xuan , Wu Tian 
Published: November 2022

Scopoletin, the main component of clinical drugs and the functional component of health products, is highly abundant in noni fruit (Morinda citrifolia). Multiple enzyme genes regulate scopoletin accumulation. In the present study, differentially expressed genes of noni were analyzed by RNA sequencing (RNA-Seq) and the full-length genes by isoform-sequencing (Iso-Seq) to find the critical genes in the scopoletin accumulation mechanism pathway. A total of 32,682 full-length nonchimeric reads (FLNC) were obtained, out of which 16,620 non-redundant transcripts were validated. Based on KEGG (Kyoto Encyclopedia of Genes and Genomes) annotation and differential expression analysis, two differentially expressed genes, caffeic acid 3-O-methyltransferase (COMT) and caffeoyl-CoA O-methyltransferase (CCoAOMT), were found in the scopoletin accumulation pathway of noni. Real-time quantitative polymerase chain reaction (q-PCR), phylogenetic tree analysis, gene expression analysis, and the change in scopoletin content confirmed that these two proteins are important in this pathway. Based on these results, the current study supposed that COMT and CCoAOMT play a significant role in the accumulation of scopoletin in noni fruit, and COMT (gene number: gene 7446, gene 8422, and gene 6794) and CCoAOMT (gene number: gene 12,084) were more significant. These results provide the importance of COMT and CCoAOMT and a basis for further understanding the accumulation mechanism of scopoletin in noni.
TREATMENT RESULTS OF PATIENTS WITH FRACTURE-DISLOCATION OF THE FOREARM BONES
Authors: Domansky A. N. , Loskutov A. E. 
Published: November 2022

Purpose of the study: to analyze the treatment results of fracture dislocations of the forearm bones.
Materials and research methods. In the traumatology department of the KP “Dnepropetrovsk Regional Clinical Hospital named after I.I. Mechnikov "DOR" 63 patients with fracture dislocations of the proximal forearm bones has been trested from 2016 to 2020. Taking into account the peculiarities of damage to the stability components of the elbow joint, all patients were divided into 3 groups depending on the type of damage to various anatomical stabilizers of the elbow joint: dislocation fractures of the Monteggi type, fractures of Malgene dislocation (through-olecranial fractures), “terrible triad”.
Results. In the Monteggi fracture dislocation group (n = 24), excellent and good long-term functional results in 16.7% and 45.8% of patients, respectively, satisfactory - in 20.8% and unsatisfactory - in 16.7%. In the Malgeny fracture dislocation group, the majority of patients had excellent and good results - 14 (87.5%), satisfactory - in 2 (12.5%), there were no unsatisfactory results. In the group "terrible triad of the elbow joint" excellent results were obtained in 3 cases (15.8%), good - in 7 (36.8%), satisfactory - in 4 (21.1%), and unsatisfactory - in 5 (26 , 3%).
Conclusions. Stable-functional osteosynthesis with the restoration of bone and soft tissue stabilizers of the elbow joint, with the possibility of active early restoration of the function of the elbow joint, help to reduce the period of disability and give positive results in 84.7% of patients.
MODERN INDIVIDUAL-COMPREHENSIVE APPROACH IN THE TREATMENT OF HEMORHOIDS
Authors: Militsa M. М. , Postolenko M. D. , Militsa K. M. , Soldysova V. V. 
Published: November 2022

Objective. The aim of the study was to analyze the effectiveness of modern treatments in 485 patients with chronic hemorrhoids stage II-III-IV over the past 3 years.
Results. An individual-combined approach to the treatment of hemorrhoids has been introduced, as many patients can have nodules at different stages of the disease at the same time. Used a combination of methods with different ways to influence the pathogenesis of hemorrhoids. Thanks to the introduction of a set of systemic measures, good results were obtained, namely the healing time of postoperative wounds was reduced by 35-40% and the intensity of postoperative pain was reduced by 3-4 points on a 10-point analog visual scale.
Conclusions. The use of an individual integrated approach to each patient in choosing the tactics of surgical treatment of hemorrhoids and the widespread introduction of modern techniques, has reduced the duration of the postoperative period, preserve radical intervention and reduce the likelihood of recurrence.
Application of Data Mining for Slot Time Prediction at International Airports in Indonesia: J48 Algorithm
Authors: Renddy Wandhana Suryaman  , Gunawan Wang  , Viany Utami Tjhin  
Published: November 2022

Abstract
In aviation, the safety and smooth flow of flight traffic is a business core, where every flight traffic service is expected to avoid delays caused by aircraft movement either in the air or on land. Therefore, the time slot at the airport is essential for the accuracy of the movement of aircraft, both Departure and Arrival, and this is intended to avoid delays caused by the accumulation of queues of planes that will depart and planes that will land, with a large number of aircraft movements at the International Airport. Soekarno Hatta requires analysis with data mining techniques such as the J48 algorithm and Decision Tree, and Naïve Bayes.
Ademetionine: Physiological Effects and Use in Treatment of Liver Diseases
Authors: Силивончик Н.Н. , Адаменко Е.И. , Богуш Л.С. 
Published: November 2022

В статье изложены данные о физиологической роли адеметионина (S-аденозил-L-метионина, SAMe) в организме человека, особенностях метаболизма адеметионина при заболеваниях печени. Представлены экспериментальные данные, обосновывающие применение адеметионина при заболеваниях печени. Выполнен обзор литературных данных о результатах исследования адеметионина в качестве лекарственного средства при внутрипеченочном холестазе, в том числе связанном с беременностью, алкогольной болезни печени, неалкогольной жировой болезни печени, вирусных заболеваниях печени, поражениях печени на фоне химиотерапии.
The data on a physiological role of ademethionine (S-adenosyl-L-methionine, SAMe) in a human, special aspects of ademetionine metabolism in the context of liver disease are stated in this article. The experimental data proving use of ademethionine at liver diseases are presented. The review of literary data on results of ademethionine clinical research at the intrahepatic cholestasis including intrahepatic cholestasis of pregnancy, an alcoholic liver disease, nonalcoholic fatty liver disease, viral liver diseases, and liver damage due to chemotherapy is executed.
Penerapan Strategi Bisnis di Masa Pandemi Covid-19 (Studi pada UMKM Wizz Kitchen Aceh Barat)
Authors: Intassar Husen Tamitha , Mandaraira Fitria 
Published: November 2022

AbstractThis study was conducted to determine the business strategies implemented by Micro, Small and Medium Enterprises in dealing with the COVID-19 pandemic. The object of this research is the food industry with the trademark Wizz Kitchen which is located on Jln. Nasional Meurebo District, West Aceh Regency. The method used is a qualitative research method with a descriptive approach. From the results of the study, it is known that the use of the internet and social media as a means of marketing and supported by good quality products and services is the right business strategy to be implemented, especially in the midst of the Covid-19 pandemic, in addition to maintaining business continuity, it can also improve networks and build an image from consumers so that it can encourage business growth.Keywords : Business Strategy, Social Media, Product and Service QualityAbstrak Penelitian ini dilakukan untuk mengetahui strategi bisnis yang diterapkan oleh pelaku Usaha Mikro, Kecil, dan Menengah (UMKM) dalam menghadapi pandemi covid-19. Objek penelitian adalah industri makanan dengan merek dagang Wizz Kitchen yang berlokasi di Jln. Nasional Kecamatan Meurebo Kabupaten Aceh Barat. Metode yang digunakan adalah metode penelitian kualitatif dengan pendekatan deskriptif. Dari hasil penelitian diketahui bahwa pemanfaatan internet dan media sosial sebagai sarana pemasaran serta di dukung dengan kualitas produk dan pelayanan yang baik adalah strategi bisnis yang tepat untuk diterapkan terutama di tengah pandemi Covid-19, selain dapat mempertahankan kelangsungan usaha juga dapat meningkatkan jaringan serta membangun citra yang baik dari konsumen sehingga bisa mendorong pertumbuhan bisnis.
SEMANGAT UMKM DIBALIK PANDEMI COVID-19 PADA OBJEK WISATA SUNGAI GELOMBANG DI DESA SIPUNGGUK KECAMATAN SALO KABUPATEN KAMPAR
Authors: Risman Risman , Yapentra Arhifen , Iskandar Iskandar 
Published: November 2022

Penelitian ini dilakukan di objek wisata sungai Gelombang Desa Sipungguk Kecamatan Salo Kabupaten Kampar. Rumusan masalah pada penelitian ini adalah Bagaimana semangat UMKM dibalik Pandemi Covid-19 pada Objek Wisata Sungai Gelombang di Desa Sipungguk Kec. Salo Kabupaten Kampar . Tujuan penelitian adalah Untuk mengetahui semangat UMKM dibalik Pandemi Covid-19 pada Objek Wisata Sungai Gelombang di Desa Sipungguk Kec. Salo Kabupaten Kampar . Metode penelitian menggunakan metode deskriptif kualitatif, peneliti menggunakan informan atau narasumber sebagai sumber data, penelitian ini dapat disimpulkan bahwa UKMK yang berada di Objek Wisata Sungai Gelombang di Desa Sipungguk ini dijalankan secara sederhana, mereka belum ada kemitraan dengan pihak lain, perlu ada pembinaan UMKM yang serius oleh pemerintah setempat yang terintegrasi dengan manajemen pariwisata, fasilitas yang ada di objek wisata ini belum tertata dengan baik, masih perlu pembinaan dari pemerintah setempat agar UMKM kedepan bisa meningkat sejalan dengan perkembangan pengembangan pariwisata yang ada. Sarana dan prasarana serta kuliner wisata perlu dibenahi dan dikembangkan lebih lanjut agar objek wisata lebih menarik dan Usaha Mikro Kecil dan Menengah ( UMKM ) mampu meningkatkan pendapatan dan kesejahteraan masyarakat.
STRATEGI PENGEMBANGAN KULINER LOKAL UNTUK MENINGKATKAN KUALITAS PRODUK OLAHAN IKAN PATIN DI KAMPUNG PATIN DESA KOTO MASJID KABUPATEN KAMPAR KECAMATAN XIII KOTO KAMPAR PROVINSI RIAU
Authors: Yanti Delfi , Maryantina Maryantina 
Published: November 2022

AbstractPengembangan Kuliner Produk Olahan Ikan Patin di Kampung Patin desa Koto Mesjid Kabupaten Kampar dipengaruhi oleh 14 faktor internal dan 13 faktor eksternal yang mempengaruhi pengembangan Produk Olahan dan budi daya Ikan Patin di Kabupaten Kampar. Strategi Pengembangan Kuliner Lokal produk olahan ikan patin di Kampung patin Koto Mesjid Kecamatan XIII Koto Kampar seharusnya dikelola dengan tepat baik, dan bijaksana sehingga menjadi salah satu sektor penunjang perekonomian daerah pada umumnya dan masyarakat sekitar khususnya serta dapat meningkatkan kualitas produk olahan ikan patinnya. Keikutsertaan masyarakat tentunya sangat dipengaruhi oleh kemauan, kesempatan, dan kemampuan dari masyarakat Kampung patin Koto Mesjid Kampar. Dalam perencanaan desa wisata, memberikan dorongan bagi masyarakat untuk berpartisipasi aktif dalam pelaksanaan dan pengawasan. Kampung Patin Koto Mesjid Kampar juga merupakan desa wisata edukasi seperti pelatihan Pembuatan Produk olahan ikan patin dan menjadi oleh-oleh tersendiri bagi wisatawan yang berkunjung dan dapat menjadi daya tarik wisata kampung patin itu sendiri
Keywords:Strategi Pengembangan, Kualitas Produk, ikan Patin, Kuliner Lokal