bluuebunny/crossref_metadata_2025_split huggingface dataset:
New Model for Vertical Distribution and Variation of Atmospheric Water Vapor – A Case Study for China
Authors: Zhang Kefei , Wan Moufeng , Wu Suqin , Shen Zhen , Zhu Dantong , Sun Peng , Li Longjiang 
Published: April 2022

Abstract
For better modeling the variations in the vertical distribution of water vapor, in this study, a new function for the vertical variation in water vapor was derived, named lapseRPWV. From the analyses of lapseRPWV time-series, it was found that its vertical distribution is strongly correlated with the relative magnitude of total precipitable water vapor (TPWV). This study proposed a method that used six data ranges of TPWV to determine the relative magnitude of TPWV. For the periodic variations in the classified lapseRPWV time-series in each of six TPWV ranges, a spatio–temporal lapseRPWV model was developed for each range. The new models were validated by comparing their predictions against the references from sounding data at 12 radiosonde stations in China, and their performances were also compared with that of the commonly used water vapor scale height (H) model. Results showed that, first, the number of stations that had reduced annual RMSE of H values in TPWV ranges from 1 to 6 accounted for 92%, 92%, 67%, 83%, 100%, and 100% of the total stations, respectively. Second, the proportions of the height range that had reduced annual RMSE of water vapor density (WVD) in all height ranges within all TPWV ranges were above 75% at the 12 stations. Last, considering all TPWV ranges as a whole, in each of 10 height ranges, the annual RMSEs of WVD of all the stations reduced at least 11%, 20%, 43%, 48%, 40%, 38%, 32%, 35%, 32%, and 28%, respectively.
Association between hemodialysis and fall risk in older adults with multiple diseases
Authors: Yang Rumei , Wan Lihong , Liu Jin , Zhao Weihong , Li Ting , Pei Xiaohua , Qin Wenting 
Published: April 2022

Abstract
Objectives: Falls are a major cause of morbidity and disability in older adults with multiple diseases. This study aimed to evaluate whether hemodialysis is related to fall risk in older adults with multiple diseases ,and to explore the effect of dialysis on falls was mediated through the ratio of Cr / CysC and activities of daily living (ADL).Methods: This retrospective study included patients aged ≥60 years-old with at least two comorbid diseases admitted to the Geriatric Nephrology Department of Jiangsu Province Hospital between December 2019 and June 2021. Clinical data were extracted from the medical records. Fall risk was evaluated with a modified Thomas scale. Results: The study included 91 patients in the non-hemodialysis group and 40 patients in the hemodialysis group. The hemodialysis group had lower activities of daily living (ADL) and higher body mass index/skeletal muscle index (SMI) ratio and modified Thomas score than the non-hemodialysis group. Linear regression revealed that older age (b= 0.07, 95% confidence interval [95%CI] = 0.06-0.09, P < 0.001) and hemodialysis (b= 0.67, 95%CI = 0.27-1.06, P = 0.001) were associated with higher fall risk. Hemodialysis exerted a significant direct effect on the modified Thomas fall risk score (b = 0.526, 95%CI = 0.432–1.433, P = 0.015) as well as a significant indirect effect via the Barthel index (b = 0.172, 95%CI = 0.010–0.333, P = 0.037)Conclusion: Hemodialysis increases the risk of falling in older adults with comorbidities. The effects of hemodialysis on fall risk were direct and indirect. Identifying inpatients on hemodialysis who are at risk of falling would facilitate targeted intervention strategies.
TAT-W61 peptide reduces the inflammation and apoptosis by inhibiting the binding S100b to the V-domain of Rage during ischemic stroke
Authors: Liang Jia , Li Hui , Ma Xiang-Yu , Liu Dan , Chen Yu-Ling , Feng Qian , Zhang Zhen , Wen Xiang-Ru , Wang Nan , Song Yuan-Jian 
Published: April 2022

Abstract
Ischemic stroke is a nervous system disease associated with high mortality and morbidity rates. Currently, there are no neuroprotective drugs for this disease. S100 calcium-binding protein b (S100b), which is abnormally expressed in the cerebrospinal fluid of patients, can bind to various other proteins and exacerbate the progression of stroke; receptor for advanced glycation end-products (Rage) is one of these proteins. To inhibit the occurrence of this interaction, a peptide (TAT-W61) based on the V-domain of S100b that interacts with Rage was produced. This study aimed to use TAT-W61 to reduce the levels of inflammation and apoptosis after ischemic stroke and to improve learning memory and motor dysfunction. In this study, S100b and Rage expression increased after ischemic stroke. Possible binding sites of S100b on Rage were mapped through molecular docking and polar–contact assays. In immunoprecipitation experiments, TAT-W61 inhibited the binding of S100b to Rage after ischemic stroke. TAT-W61 peptide, derived from Rage, could reduce the inflammatory and apoptotic response caused by ischemic stroke. It may also improve the infarct volume of the pathological injury and reduce the apoptotic rate. In particular, the TAT-W61 peptide could significantly improve learning, memory, and motor dysfunction in an ischemic stroke model. TAT-W61 peptide may help alleviate ischemic stroke injury.
Investigation of the Relationship between Maxillary Dimensions and Labial and Palatal Maxillary Impacted Canines Using Cone Beam Computed Tomography
Authors: Karaman Ahmet , Genc Esra 
Published: April 2022

Abstract
Objectives: To compare the maxillary dimensions of individuals with labial and palatal bilateral maxillary canine impaction and a control group of individuals with no impaction using CBCT. Materials and Methods: 45 patients were included in the study with age range of 13 to 18 and consisted of 22 females and 23 males. The sample included three groups of 15 patients as the control, labial and palatal group. The measurements made on the axial and coronal planes were made on the levels of the 1st premolar and the 1st molar. Also nasal cavity and anteroposterior depth were measured. Results: The maxillary anteroposterior depth, basal first molar width, alveolar first molar and premolar width and first molar palatal vault depth of the control group were significantly higher than labial and palatal groups (p<0.05).The basal first premolar width of the control group was significantly higher than palatal group (p<0.05). The first premolar palatal vault depth and nasal cavity width of the palatal group were significantly lower than other groups (p<0.05).Conclusions: The basal and alveolar widths associated with the molars and the palatal depths were lower in the impacted group than control group. The anatomical structures in the female patients were affected by the position of impaction to a higher extent in comparison to the anatomical structures in the male patients.Clinical Relevance: In the case of impaction of maxillary canines, the dimensions of the arch will be smaller and the maxillary base of the dental arches will be less developed.
Design of Backstepping Control for Nonlinear Systems based on Command Filter and Uncertainty Estimation
Authors: Zhou Lan , Jiang Fuxi , Sun Yongbo , Pan Changzhong , Zhang Zhu 
Published: April 2022

Abstract
This paper presents an improved command-filtered backstepping control method for a class of multi-source-disturbed nonlinear systems based on an active-uncertainty-estimation-and-compensation approach. Exploiting the available model information of a plant, a reduced-order extended-state observer is designed to estimate a matched total uncertainty. Command filters are constructed to estimate virtual control inputs. Both the estimated states and estimation errors are used for the construction of the backstepping control law, which guarantees the stability of the system and compensates for uncertainties. Moreover, a particle-swarm-optimization algorithm is adopted to simultaneously optimize the state observer gain and backstepping-control gains. Finally, a case study on a rotational system shows that the presented method achieves better uncertainty-suppression and tracking performance in both transient and steady state than other related methods.
Non-blind Arnold Scrambled Hybrid Digital Image Watermarking Scheme based on Differential Evolution and DnCNN
Authors: Amiri Ali , Kanan Hamidreza Rashidy 
Published: April 2022

Abstract
Watermarking is to place a message invisibly in the media without damaging it. Transform (frequency) domain based watermarking has received more attention due to its advantages over spatial domain. Many algorithms which utilize SVD, have a false positive problem. Therefore, this study propose a scheme that along with the robustness of the cover image to the various attacks, maintains the imperceptibility of the watermarked image. To achieve these goals, we use three transforms along with Differential Evolution algorithm. Also, to obtain the best multiple scaling factors, we modify the unique values of SVS of the low resolution approximate image which is obtained in the embedding process. To further increase the security of the proposed method, we scrambled the cover image using Arnold’s transform. We also did not use the U and V diagonal components in the embedding and extracting steps to prevent false positives.
Bicyclol Attenuates Obesity-induced Cardiomyopathy via Inhibiting NF-κB and MAPK Signaling Pathways
Authors: Chen Yanghao , Lin Wante , Zhong Lingfeng , Fang Zimin , Ye Bozhi , Wang Zhe , Chattipakorn Nipon , Huang Weijian , Liang Guang , Wu Gaojun 
Published: April 2022

Abstract
Purpose: Schisandra is a well-known traditional Chinese medicine in East Asia. As a traditional Chinese medicine derivative with Schisandra chinensis as raw material, bicyclol is well known for its significant anti-inflammatory effect. Chronic inflammation plays an significant part in obesity-induced cardiomyopathy. Our purpose was to explore the effect and mechanism of bicyclol on obesity-induced cardiomyopathy. Methods: Mice fed with a high-fat diet (HFD) and cardiomyocytes stimulated by palmitic acid (PA) were used as models of obesity-related cardiomyopathy in vivo and in vitro, respectively. The therapeutic effect of bicyclol on pathological changes such as myocardial hypertrophy and fibrosis was evaluated by staining cardiac tissue sections. PCR was used to detect inflammatory factors in H9c2 cells and animal heart tissue after bicyclol treatment. Then, we used western blotting to detect the expression levels of myocardial hypertrophy related protein, myocardial fibrosis related protein, NF-κB and MAPK pathways.Results: Our results indicated that bicyclol treatment significantly alleviates HFD-induced myocardial inflammation, fibrosis and hypertrophy by inhibiting the MAPK and NF-κB pathways. Similar to animal level results, bicyclol could significantly inhibit PA-induced inflammation and prevent NF-κB and MAPK pathways to be activated.Conclusion: Our results showed that bicyclol is expected to become a potential drug to treat obesity-induced cardiomyopathy.
Research on pilot perceived intention method based on EEG and visual fixation fusion
Authors: Jiang GuangYi , Chen Hua , Wang ChangYuan , Xue PengXiang 
Published: April 2022

Abstract
Situational awareness is the ability of pilots to master flight status, which is of great significance to aviation flight safety and flight effect. According to the information processing model, the pilot's main steps of processing information are feeling, perception and execution. There are many problems in situation awareness analysis guided by visual gaze, such as large analysis deviation and high delay due to various influencing factors and complex characteristics. In order to solve this problem, this paper proposes a situation awareness assessment method based on artificial intelligence neural network and integrating visual gaze and flight control. Firstly, this paper carries out simulated flight training experiments for flight cadets, and collects the data of eye movement, line of sight tracking, flight control and flight parameters of pilot cadets. Then, aiming at the flight subjects, a situation awareness analysis method based on events is established, and the situation awareness state in the experiment is evaluated and analyzed through the flight parameter data. Then, the visual gaze and flight control data are sliced in the unit of situational awareness events, and the data set is constructed. Finally, this paper designs a multi-channel sequence data classification and analysis model integrating transformer, in which the situation awareness characteristics of visual gaze and operation behavior are analyzed through the attention mechanism. The experimental results show that the accuracy of situation awareness classification of the designed neural network model to the experimental data set is 96%, and can classify and evaluate the pilot's situation awareness state in 5 seconds.
A cross-sectional study on the psychological changes of medical personnel in hospitals who experienced special COVID-19 situations
Authors: Yoo Byung Wook , Yan Xiao Guang , Sun Hwa Yeon 
Published: April 2022

Abstract
COVID-19 pandemic led to an increase in psychological problems; health professionals with higher exposure to risk of infection suffer psychological changes. This study aimed to investigate the level of anxiety, anger, and depression among health professionals in COVID-related special circumstances. A mass COVID-19 outbreak occurred in a general hospital in Korea. In total, 149 frontline and non-frontline health professionals involved in this were surveyed. Their anger, anxiety, and depression were assessed using the State-Trait Anger Expression Inventory, General Anxiety Disorder-7, and the Korean Screening Tool for Depressive disorders. By occupation, health professionals showed relatively higher anxiety and depression than non-health professionals. By type of work, frontline staff showed a higher level of depression than non-frontline staff. The results confirmed that healthcare staff underwent psychological changes during the COVID-19 pandemic. It is important to raise awareness on post-traumatic stress disorder affecting health professionals during the COVID-19 pandemic.
Inhibition of GPX4 Induces the Death of p53-Mutant Triple-Negative Breast Cancer
Authors: Tahaney William M. , Qian Jing , Moyer Cassandra L. , Nguyen Nghi , Lanier Amanda , Ma Yanxia , Hill Jamal , Powell Reid T. , Stephan Clifford C. , Mazumdar Abhijit , Davies Peter J.A. , Brown Powel H. 
Published: April 2022

Abstract
Background
Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer, characterized high rates of tumor protein 53 (p53) mutation and limited targeted therapies. Despite being clinically advantageous, direct targeting of mutant p53 has been largely ineffective. Therefore, we hypothesized that there exist pathways upon which p53-mutant TNBC cells rely upon for survival.
Methods
In vitro and in silico drug screens were used to identify drugs that induced preferential death in p53-mutant breast cancer cells. The effects of the glutathione peroxidase 4 (GPX4) inhibitor ML-162 was deleniated using growth and death assays, both in vitro and in vivo. The mechanism of ML-162 induced death was determined using small molecule inhibition and genetic knockout.
Results
High-throughput drug screening demonstrated that p53-mutant TNBCs are highly sensitive to peroxidase, cell cycle, cell division, and proteasome inhibitors. We further characterized the effect of the Glutathione Peroxidase 4 (GPX4) inhibitor ML-162 and demonstrated that ML-162 induces preferential ferroptosis in p53-mutant, as compared to p53-wild type, TNBC cell lines. Treatment of p53-mutant xenografts with ML-162 suppressed tumor growth and increased lipid peroxidation in vivo. Testing multiple ferroptosis inducers demonstrated p53-missense mutant, and not p53-null or wild type cells, were more sensitive to ferroptosis, and that expression of mutant TP53 genes in p53-null cells sensitized cells to ML-162 treatment. Finally, we demonstrated that p53-mutation correlates with ALOX15 expression, which rescues ML-162 induced ferroptosis.
Conclusions
This study demonstrates that p53-mutant TNBC cells have critical, unique survival pathways that can be effectively targeted. Our results illustrate the intrinsic vulnerability of p53-mutant TNBCs to ferroptosis, and highlight GPX4 as a promising target for the precision treatment of p53-mutant triple-negative breast cancer.
Climate change driven shifts in plant-soil feedbacks – A meta-analysis
Authors: Hassan Kamrul , Dastogeer K. M. Golam , Carrillo Yolima , Nielsen Uffe N 
Published: April 2022

Abstract
PurposeClimate change is expected to affect plant-soil feedbacks (PSFs), influencing plant community dynamics and, through this, ecosystem functioning. However, our knowledge of effects on the magnitude and direction of PSFs is limited, with considerable variability between studies.MethodsWe quantified PSF effect sizes associated with common climate change factors, specifically drought and warming, using a meta-analytical approach. We investigated whether effects were consistent across functional groups, life histories (annual versus perennial, native versus non-native), planting (monoculture, mixed culture) and experimental conditions (field, greenhouse/laboratory). ResultsDrought induced stronger negative PSFs relative to ambient conditions while warming had no main effect. The response to drought was largely driven by stronger negative PSFs in grasses, suggesting that grasses may be more sensitive to drought. Interestingly, drought induced negative PSFs only in non-native species, suggesting that native species may better adapted to tolerate water stress. By contrast, we found an opposite in pattern in response to warming which may then favour invasive species. Perennial herbs displayed stronger negative PSFs than annual herbs in response to drought. Mixed species communities displayed more negative PSFs than monocultures, independent of climate treatment. Finally, warming and drought treatment PSF effect sizes were more negative in experiments performed in the field than under controlled conditions.ConclusionWe provide evidence that drought and warming can induce shifts in PSFs, which are dependent on plant functional groups, life history traits and experimental conditions. These shifts would be expected to have implications for plant community dynamics under projected climate change scenarios.
Accelerated ageing test reveals quantitative nature of inheritance of seed viability in soybean [Glycine max (L.) Merr]
Authors: Saini Manisha , Yadav Raju Ratan , Chandra Subhash , Kumar Ashish , Kumar Rahul , Sheoran Seema , Rathod Nenavath Krishna Kumar , Yadav Manu , Taku Meniari , Basu Sudipta , Lal S.K. , Talukdar Akshay 
Published: April 2022

Abstract
Soybean [Glycine max (L.) Merrill] (2n=40), an important source of the premium quality protein (40%) and oil (18-20%), suffers from poor viability of the seeds during ambient storage. The current study aimed to understand the genetic control of seed viability in soybean and its association with other traits through accelerated ageing test. A set of 119 F2:3 seeds from a cross between good storing genotype EC1023 (91.87% germination after 1 year of ambient storage) and poor-storing genotype VLS61 (60.87% after 1 year of ambient storage) were tested for viability and vigour through accelerated ageing (AA) test. The parameters of the AA testing, which were initially standardized from six different combinations, were-temperature: 41± 1 0 C, duration: 72 hours and relative humidity (RH): ~100%. The tested seeds differed significantly for viability and vigour index I and II, which ranged from 4.16 to 71.42%. The continuous distribution of the viability percent of the F2:3 seeds indicated an involvement of more than one gene in controlling the viability of the seeds. The percent seed germination found to be positively and significantly correlated with the average seedling length (r=0.78) and seedling dry weight (r=0.83). Similarly, seedling length was found to be positively and significantly associated with seedling dry weight (r=0.92). The information on genetic control of viability of soybean seeds along with its vigour indices would pave the way for mapping and deploying the genes for improvement of viability in soybean.
Interleukin-6 as a predictor of early weaning from invasive mechanical ventilation in COVID-19 patients with acute respiratory distress syndrome
Authors: Sakai Kazuya , Nishii Mototsugu , Saji Ryo , Matsumura Reo , Abe Takeru , Takeuchi Ichiro 
Published: April 2022

Abstract
Therapeutic efficacy of steroids on acute respiratory distress syndrome (ARDS) requiring mechanical ventilation (MV) has been reported. However, predictive indicators of early weaning from MV in such cases have not yet been defined. Our aim was to clarify clinical utility of interleukin (IL)-6 level in ventilated patients with established ARDS. Clinical, treatment, and outcome data were evaluated in 119 invasively ventilated patients with ARDS caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Plasma levels of IL-6 and C-reactive protein (CRP) were measured on days 1, 4, and 7 after intubation. Fifty-two patients received dexamethasone (steroid group) and the remaining 67 did not (non-steroid group). Duration of MV use was significantly shorter in the steroid group compared to non-steroid group (11.5±0.6 vs. 16.1±1.0 days, P = 0.0005, respectively). Even when restricted to the steroid group, among the post-MV variables, the IL-6 level on day 7 was most closely correlated with the duration of MV use and showed the highest accuracy for withdrawal from MV within 11 days (AUC: 0.88), with optimal cutoff value of 20.6 pg/mL. Collectively, in intubated patients with ARDS due to SARS-CoV-2 who received dexamethasone, plasma IL-6 levels served as a predictor of early withdrawal from MV.
Evaluation salivary level of Glutathion reductase, Catalase and Free thiol in patients with temporomandibular joint disorder
Authors: Rezazadeh Fahimeh , Fassihi Nima , Mahdavi Dorsa , Tabesh Amir , Khorami Elham Tayebi , sedarat hossein 
Published: April 2022

Abstract
Introduction:
Temporomandibular joint disorders (TMD) are characterized by jaw pain combined with dysfunction of the muscles and joints. Extreme fabrication of oxidative stress in the TMJ thus results in tissue injury, which advances to TMD.The aim of this study was to evaluate the Glutathion reductase, catalase, and free thiol in saliva of TMD patients and compare it with people without TMD.
Materials and Methods
In this cross sectional study 35 patients with temporomandibular joint and 20 people without TMD were participated in the study. Five mL of each unstimulated saliva sample was collected in the morning and salivary level of antioxidants was assessed by ELISA (Enzyme Linked Immunosorbent Assay) technique. Helkimo index and visual analogue scale (VAS) also were measured during this experiment.
Results
There was significantly decrease in salivary level of Glutathion reductase and catalase in patients but there were no differences among two groups in free-thiol level.There was also correlation between antioxidant status and presence of click, pain and severity of disease; however, there was no correlation between age and gender with antioxidants contents.
Conclusion
The mean salivary levels of Glutathion reductase and Catalase in TMD patients were lower than that in the control group, which means these antioxidants were affected by TMD and also related with severity of it, but no significant difference was detected in salivary Free thiol between groups. So salivary Glutathion reductase and Catalase level may be used as a biomarker for TMD monitoring and treatment.