bluuebunny/crossref_metadata_2025_split huggingface dataset:
The effect of Patient’s Race on the Outcome of Endodontic treatments: a pooled analysis of 1 year recall data from four Cone Beam Computed Tomography outcome studies
Authors: Patel Neha , Scambler Sasha , Ranjbari Mohammadreza , Alhammad Mohammad , Bakhsh Abdulaziz , Mannocci Francesco 
Published: July 2022

Abstract
ObjectivesThe aim of this pooled data analysis was to establish if there is an association between a patient’s race and the proportion of successful outcomes of endodontic treatments, and if so, what factors may determine this association.MethodologyData collected from four prospective clinical outcome studies were pooled. Patients were recalled 12 months after the completion of the treatment. Treatment outcome was determined by clinical findings and cone beam computed tomography (CBCT) examination. Statistical analysis included the description of categorical and continuous variables and simple binary logistic regression models, Chi2 tests and Kruskal-Wallis tests.ResultsData from 301 patients were available, of which 43 were black (14.3%), 50 were non-black minority ethnic (NBME) (16.6%) and 208 white (69.1%). The risk of an unfavourable outcome was higher in teeth with short root canal fillings (OR=3.36; p=0.002), when a preoperative radiolucency was present (OR=2.59; p=0.019) and when an intra-operative root canal perforation was detected (OR=5.25; p=0.016).Multiple regression models showed that black (OR=2.28; p=0.05) and NBME patients (OR=3.07; p=0.008) had a higher risk of an unfavourable result compared to white patients. ConclusionsBlack and NBME patients had a significantly higher failure rate of root canal treatments compared to white patients, all other known pre, intra and post-operative risk factors for root canal treatment failure were present in similar proportions in BME and white patients.
It’s all about the mirrors: Deep neural network assisted optimization of laser stabilization cavities
Authors: Dickmann Johannes , Neto Liam Shelling , Gaedtke Mika , Kroker Stefanie 
Published: July 2022

Abstract
Ultra-stable laser cavities are the core components of today’s most precise measurement instruments. To design and realize an ultra-stable laser cavity, one must suppress all kinds of noise below the desired frequency stability. The thermal noise of the cavity spacer sets a fundamental limit for the possible stability, especially for cavities operating at room temperature. We present a comprehensive numerical study of thermal cavity spacer noise, accounting for all relevant geometrical parameters. Accelerated by a vast amount of simulation data, a neural network is trained to predict spacer noise precisely for a wide range of all relevant cavity parameters. Based on this neural network, we identified design rules to reduce spacer noise by more than 50% by only changing the cavity geometry. Optimizing the cavity geometry and the material combination can achieve a noise reduction of more than two orders of magnitude without the infrastructural effort of a cryogenic environment.
A New workflow applied to flash-frozen biological samples allows to surpass electron-dose limitations intrinsic to high-resolution Electron Microscopy Tomography
Authors: Fera Andrea 
Published: July 2022

Abstract
Recently low-temperature treatments applied to flash-frozen biologics resulted in bypassing the majority of electron-dose limitations for electron microscopy tomography. Although samples may not be considered free from artefacts at this stage, structures do not show typical distortions implicit to air-drying, and are able to sustain the rigors implicit to a tomography scan with >120 images at high-electron dose, necessary to maximize the signal-to-noise (since detectors measured with Poissonian statistics). Very recent experiments demonstrated that metal ions chemically adsorbed to the surface of proteins are not necessary, nor they create major rearrangements above a few Å length scales. Here results on very deformable samples are discussed, which this conditioning protects from destruction as before documented. Temperature Conditioning putatively allows to image directly before solvent evaporation. Here for the first time images pertaining both a notoriously soft materials (like enveloped virus) and a rigid biopolymer (microtubules of pure tubulin) are disclosed revealing unexpected structures, much larger than inter-atomic distances. In order to retain only protecting effect on flash-frozen biological samples, probably the origin of artifacts needs to be investigated, possibly studying distance and geometry of metal ions bonds to proteins. This may be done in-situ using aberration corrected microscopes.
Adequate preoperative hemoglobin level in patients with thoracic and lumbar tuberculosis: A single center retrospective cohort study
Authors: Jiang Guanyin , Du Xing , Zhang Muzi , Qin Wanyuan , Xiong Tuotuo , Ou Yunsheng 
Published: July 2022

Abstract
Objective
This study aimed to find out the risk factors of postoperative moderate anemia (PMA) to develop a scoring scale for predicting the occurrence of PMA and to determine the recommended preoperative hemoglobin level in spinal tuberculosis (STB) patients.
Methods
A total of 223 STB patients who underwent focus debridement from January 2012 to March 2020 were enrolled in the study. The study cohort was divided into two groups owing to the occurrence of PMA. Moderate anemia was defined as a hemoglobin level of < 90 g/L. The clinical characteristics of STB patients who developed PMA were evaluated, and a scale was developed by logistic regression analysis. The performance of this scoring scale is prevalidated.
Results
Of the 223 patients, 76 developed PMA. Multivariate binary logistic regression analysis showed that body mass index, diabetes, low preoperative hemoglobin level, long operation time, and posterior approach were independent risk factors for PMA in STB patients. These significant items were assigned scores to create a scoring scale as to predicting PMA, and receiver operating characteristic (ROC) curve analysis implicated that the optimal cutoff score was 4 points. On the basis of the scoring scale, patients with scores within 0–3 points were defined as the low-risk group; those with scores within 4–6 points were defined as the moderate-risk group; and those with scores within 7–10 points were defined as the high-risk group. The perioperative decrease in hemoglobin level was 20.07 ± 10.47 g/L in the low-risk group, 24.44 ± 12.67 g/L in the moderate-risk group, and 29.18 ± 10.34 g/L in the high-risk group.
Conclusion
According to the scoring scale, patients with STB with a score of 0–3 points have a low risk of PMA, those with a score of 4–6 have a moderate risk, and those with a score of 7–10 have a high risk. The recommended preoperative hemoglobin levels for the low-, moderate-, and high-risk groups are 110, 115, and 120 g/L, respectively.
Multicenter Italian academic experience of elective laparoscopic cholecystectomy performed by the surgical residents
Authors: Iossa Angelo , Giuffrè Mary , Micalizzi Alessandra , Ciccioriccio Maria Chiara , Termine Pietro , De Angelis Francesco , Boru Cristian Eugeniu , Buono Giuseppe Di , Salzano Antonio , Chiozza Matteo , Agostini Carlotta , Silvestri Vania , Agrusa Antonino , Anania Gabriele , Bracale Umberto , Coratti Francesco , Cavallaro Giuseppe , Corcione Francesco , Morino Mario , Silecchia Gianfranco 
Published: July 2022

Abstract
Purpose: This retrospective study aimed to evaluate the clinical outcomes (mortality rate, operative time, complications) of elective LC when performed by a surgical resident in the backdrop of Italian academic centers.Methods: A retrospective review of all patients undergoing elective LC between January 2016 and January 2022 at six teaching hospitals across Italy was performed. Cases were identified using the Current Procedural Terminology (CPT) code 5123 (LC without cholangiogram). All cases of emergency surgery, ASA score > 3, or when cholecystectomy was performed with another surgical procedure, were excluded. All suitable cases were divided into 2 groups based on primary surgeon: consultant (group A) or senior resident (group B).Results: A total of 2331 cases (1425 females) were included, of which, consultants performed 1683 LCs, while the residents performed 648 surgeries. The groups were statistically comparable regarding demographics, history of previous abdominal surgery, operative time, or intraoperative complications (p > 0.05). The rate of conversion to open cholecystectomy was 1.42% for group A and none for Group B. However, a statistically significant difference was observed between groups A and B regarding the average length of stay and postoperative complications (2.2 ± 3 versus 1.6 ± 1.3 days, and 1.7% versus 0.5%, respectively; p < 0.05 each). Conclusions: Our study demonstrates that in selected patients, senior residents can safely perform LC when supervised by senior staff surgeons.
Machine Learning-based Opinion Extraction Approach from Movie Reviews for Sentiment Analysis
Authors: Jassim Mustafa Abdalrassual , Abd Dhafar Hamed , Omri Mohamed Nazih 
Published: July 2022

Abstract
The field of sentiment mining, also known as sentiment mining,sentiment analysis, sentiment mining, sentiment extraction, etc., has seen asurge in the university environment. Various ways to automate the processof sentiment analysis have been tested by researchers in machine learning,data mining, natural language processing, and other fields. They examine thefeelings embedded in people’s opinions and beliefs that affect multiple areas,including companies’ services and products. A movie review has to go throughmany processes to be able to detect and name feelings and achieve greateraccuracy. Due to the structure of the language, the difficulties have been increased, its grammar and dictionary management. As part of this work, wepropose a new approach for extracting words from a specific text and thenclassifying them. Thanks to a phase of pre-processing and extraction of wordsdepending on the frequency, our approach makes it possible to select between500 and 20,000 words with a vectorial construction by applying the techniquesof ”Term Frequency” (T F) and that of the ”Term frequency-Inverse DocumentFrequency” (T F − IDF). Four different Naive Bayes models were thus considered and used (Complement, Multinomial, Bernoulli and Gaussian). We evaluated our proposed approach against different standard measures namelyprecision, accuracy, recall, F1 − score and kappa. The results revealed thatthe Na¨ıve Bayes multinomial system obtained the best results with an accuracyof 86.46%.
Morphometric changes on the endometrium during diestrus stages in bitches with and without histological endometritis
Authors: Praderio Romina Gisele , Rearte Ramiro , Stornelli María Alejandra , Mitacek María Carla García , Sota Rodolfo Luzbel , Stornelli Maria Cecilia 
Published: July 2022

Abstract
The endometrium is a uterine layer essential for achieving optimal embryo implantation and development. Complete knowledge of the endometrium's normal histology is critical for advancing the diagnosis of subclinical endometrial diseases. Several researchers studied subclinical endometritis (END) in different species; however, the cause is unknown, and simple and reliable diagnostic tools are still necessary. In the bitch, diestrus has been selected as the stage of the reproductive cycle to perform diagnostic. This work aimed to perform morphometric and cytological studies in bitches with normal endometrium (NE) and END in the diestrus' different stages. Forty-five mixed-breed bitches, clinically healthy in diestrus, were used in this study. Biopsies and cytology were obtained from uterine horns, processed, and examined using a microscope. Samples from NE and END were selected, photographs were taken, and software for image analysis was used to measure the endometrial thickness (ET), external glandular diameter (EGD), and internal glandular diameter (IGD), glandular density, and glandular cells (GC) height. Significant differences were observed in GC height, EGD, IGD, and serum P4 concentrations along diestrus. In END, EGD and IGD were smaller than NE. The current study showed histomorphometric characteristics that appear to be influenced by P4 concentrations. In our opinion, it is relevant to consider the diestrus stage at the moment of the diagnosis of endometrial disease. Data recorded in the present study could be helpful to bitches with unexplained infertility or subfertility.
The plight of social workers working with children and adolescents suffering mental health disorders in South Africa
Authors: JACOBS CANDICE LEE , LEKGANYANE MADITOBANE ROBERT 
Published: July 2022

Abstract
Social workers working with children and adolescents displaying mental health disorders in the Child and Youth Care Centres (CYCCs) have an enormous responsibility to support and care for these young people. In under-resourced countries such as South Africa, their responsibility includes educating caregivers on how to better manage the conditions of these young people and to support them with behavioural changes. This responsibility is however, not free from hindrances such as a lack of relevant resources. Despite the significant role played by these social workers and their challenges in supporting these young persons, research attention is very limited in this field of social work practice. This stillness impelled an exploratory qualitative research study aiming to explore the challenges faced by social workers when rendering services to these children and adolescents. The study was conducted in South Africa’s Gauteng province, designed from exploratory and descriptive strategies and following ecological systems theory. The data collection method used was semi-structured online interviews and the collected data was analysed through Braun and Clarke’s six steps of qualitative data analysis. In ensuring data verification, the trustworthiness strategies proposed by Guba and Lincoln were adopted. The findings are presented in four themes: the general challenges of working with child and adolescent mental health disorders, the service-related challenges, challenges of dealing with complex disorders and limited resources for child and adolescent mental health disorders. Among the recommendations proposed is the design of research-based programmes to assist social workers working with case of children and adolescents with mental health disorders.
Citrobacter sp. Y3 Harboring a Novel Gene HBCD-hd-1 Mineralizes Hexabromocyclododecane (HBCD) with New Metabolic Pathways Based on Multi-omics Characterization
Authors: Peng Xingxing , Li Tianyu , Zheng Qihang , Lu Yingyuan , He Yuzhe , Tang Yetao , Qiu Rongliang 
Published: July 2022

Abstract
Background: Hexabromocyclododecane (HBCD) is a typical persistent organic pollutant that is widely detected in the environment. Until now, a microorganism resource that can degrade and even completely mineralizing HBCD is lacking. Results: By stable isotope analysis, we found that the Citrobacter sp. strain Y3 can use 13C-HBCD as its sole carbon source and degrade or even mineralize it to 13CO2 with a maximum conversion rate of 100% in approximately 14 days. Genomics, proteomics, and metabolomics were used to study the catabolic pathway of HBCD biodegradation by strain Y3. Several enzymes reportedly involved in the degradation of HBCD were identified in the strain Y3. A new functional gene named HBCD-hd-1 encoding a haloacid dehalogenase was cloned and heterologously expressed in Escherichia coli. The recombinant E. coli transformed the typical intermediate 4-bromobutyric acid (4-BBA) to 4-hydroxybutanoic acid (4-HDBA) and showed excellent degradation performance on HBCD with a degradation rate of 100% in only 2 days. Meanwhile, HBCD was well debrominated by the recombinant E. coli, because nearly 100% bromine ions were detected by ion chromatograph (IC) in vitro. Conclusion: This is the first report on the degradation function of haloacid dehalogenase in HBCD treatment. Strain Y3 can potentially degrade brominated flame retardants such as HBCD especially in a low-nutrient environment.
Carbidopa suppresses estrogen receptor-positive breast cancer via AhR-mediated proteasomal degradation of ERα
Authors: Chen Zhiwei , Xia Xing , Chen Heyan , Huang Huirong , Kou Longfa , Chen Ruijie , Chu Maoping , King Kwonseop , Yao Qing , Ganapathy Vadivel , Bhutia Yangzom D. , Zhang Hailin , An Xingsi , Sun Meng 
Published: July 2022

Abstract
Estrogen receptor-α (ERα) promotes breast cancer, and ER-positive cancer accounts for ~ 80% of breast cancers. This subtype responds positively to hormone/endocrine therapies involving either inhibition of estrogen synthesis or blockade of estrogen action. Carbidopa, a drug used to potentiate the therapeutic efficacy of L-DOPA in Parkinson's disease, is an agonist for aryl hydrocarbon receptor (AhR). Pharmacotherapy in Parkinson’s disease decreases the risk for cancers, including breast cancer. The effects of carbidopa on ER-positive breast cancer were evaluated in cell culture and in mouse xenografts. The assays included cell proliferation, apoptosis, cell migration/invasion, subcellular localization of AhR, proteasomal degradation, and tumor growth in xenografts. Carbidopa decreased proliferation and migration of ER-positive human breast cancer cells in vitro with no significant effect on ER-negative breast cancer cells. Treatment of ER-positive cells with carbidopa promoted nuclear localization of AhR and expression of AhR target genes; it also decreased cellular levels of ERα via proteasomal degradation in an AhR-dependent manner. In vivo, carbidopa suppressed the growth of ER-positive breast cancer cells in mouse xenografts; this was associated with increased apoptosis and decreased cell proliferation. Carbidopa has therapeutic potential for ER-positive breast cancer either as a single agent or in combination with other standard chemotherapies.
Microfluidic-assisted human cancer cells culturing platform for astrobiological applications
Authors: (Podwin) Agnieszka Krakos , Jarosz Joanna , Śniadek Patrycja , Psurski Mateusz , Graja Adrianna , Białas Marcin , Oliszewska Ewa , Wietrzyk Joanna , Walczak Rafał , Dziuban Jan 
Published: July 2022

Abstract
In the paper, the lab-on-chip platform applicable for the long-term cultivation of the human cancer cells, as a solution meeting the demands of the CubeSat astrobiological missions has been presented. For the first time, the selected cancer cell lines – UM-UC-3 and RT112 were cultured on-chip for up to 50 days. The investigation has been done in stationary conditions (without medium microflow) in ambient temperature, and utilizing microflow perfusion system in the incubation chamber assuring typical cultivation atmosphere (37 ºC). All the experiments were performed to imitate the conditions that are provided before the astrobiological mission starts (waiting for the rocket launch) and when the actual experiment is initialized on a CubeSat board in space microgravity. The results of the tests have shown appropriate performance of the LOC platform, especially in the context of material and technological biocompatibility. Cultured cells were characterized by adequate morphology – high attachment rate and visible signs of proliferation in each of the experimental stage. These results are a good base towards further tests of the LOC platform in both terrestrial and space conditions.
E-SOAF Network structure-based web service selection in Social Networks.
Authors: Hafsi Amal , Njima cheyma Ben , Gamha Youssef , Romdhane Lotfi Ben 
Published: July 2022

Abstract
With the growing number of identical web services available today, it's important to meet consumer needs and select relevant services. Many solutions have been presented to this difficult and complex issue. We proposed, in this paper, a Social Web Service Selection Model SWS-SM that exploits the structure of the E-SOAF network to rank web services offered by a discovery process. Our approach takes into account users feedback and suggest involving two metrics in the selection process. The first metric is time sensitivity to give importance to the most recent evaluations. The second metric is user preferences on quality of services to offer consumers services that satisfy their requirements.
Incidence of asymptomatic COVID-19 positivity in cancer patients and effects on therapy.
Authors: Liu Lisa , Ross Nicole M , Handorf Elizabeth A. , Meeker Caitlin R. , Chen Giana , Baldwin Donald , Vijayvergia Namrata 
Published: July 2022

Abstract
Purpose
The coronavirus disease 2019 (COVID-19) pandemic is posing unprecedented challenges for patient care, especially for cancer patients. This study looks at asymptomatic (AS) COVID-19 positivity in cancer patients and its effects on their care.
Methods
We conducted a retrospective chart review of AS patients testing positive for COVID-19 upon screening at Fox Chase Cancer Center between January 2020 and September 2020. Relationships between positive tests and demographics, clinical characteristics, and treatment delays were investigated using conditional logistic regression or Mantel-Haenszel tests.
Results
Among 4143 AS patients who underwent COVID-19 testing, 25 (0.6%) were COVID-19 positive (cases) and these were matched to 50 controls. The median age was lower in the cases compared to that of the controls (64 vs 70 years old, p = 0.04). Of the cases, 10 patients (40%) never underwent their planned oncologic intervention [6/10 (60%) did not require the planned intervention once deemed okay to proceed]. Of the controls, only 1 patient (2%) did not undergo the planned intervention. Of these 15 COVID-19 positive patients who underwent the planned intervention, 11 (73.3%) had a delay related to COVID-19, with a mean delay duration of 18 days (range: 0–49, SD: 16.72).
Conclusion
Cancer patients had lower incidence of AS COVID-19 than general population. Delays that occur due to AS COVID screening are not very long and serve as a tool to limit spread of virus. Further studies will be important in addressing delays in cancer care and concerns of patient safety as the pandemic continues.
Effects of aging time on microstructure and oxidation behavior of Inconel 690 alloy
Authors: Pang Baolin , Wang Man , Shen Yuegang , Xi Xiaoli 
Published: July 2022

Abstract
The microstructure and oxidation behavior of Inconel 690 alloy were investigated after aging at 850°C for different times. Also, the relationship between structural stability and oxidation behavior was analyzed. Cr23C6 appeared at grain boundaries after aging, and the shape and size of Cr23C6 changed significantly with aging time. Besides, the mechanical properties and oxidation behavior also changed with aging time. The hardness decreased first, then increased, and finally decreased to be stable. The type of oxide layer changed from (Cr, Fe)2O3 to NiCrO3, and then to (Cr, Fe)2O3 again. Oxidation shedding occurred after aging for 504 h. And, there was a porous zone beneath the oxide layer when the aging time reached 720 h. The results indicated that aging time had a significant effect on the structure stability and oxidation behavior.