bluuebunny/crossref_metadata_2025_split huggingface dataset:
CXCR4-containing Exosomes Derived From Cancer Associated Fibroblasts Promote Epithelial Mesenchymal Transition in Ovarian Clear Cell Carcinoma
Authors: Zhang Fang , Chen Liang , Li Huijuan , Liu Naifu , Zhang Xinxin , Peng Jingwei , Chen Jinlong 
Published: December 2022

Aims:
Interaction between CAFs and OCCC in the tumor microenvironment and its possible pathway.

Background:
Ovarian clear cell carcinoma (OCCC) has high invasion, metastasis and poor prognosis. Tumor invasion is facilitated by epithelial mesenchymal transition (EMT), which is associated with stromal cells of tumors that mostly consist of cancer associated fibroblasts (CAFs). Exosomes are important carriers of information exchange and transmission between cells.

Objective:
We aimed to investigate whether CAFs can induce OCCC invasion through exosomes.

Methods:
We extracted exosomes with an exosome extraction kit. Immunofluorescence staining was used to detect whether exosomes were internalized by ES2 cells. EMT-related proteins were detected, and invasion experiments were carried out to investigate whether CAFs can induce OCCC invasion through exosomes.

Results:
We found that CAF and NF exosomes could be internalized in ES2 cells. The expression of OCCC CXCR4 protein could be increased by adding the supernatant of CAFs, but there was no significant change in the expression of CXCR4 mRNA. CXCR4 protein expression in CAF exosomes was significantly higher than that in NFs. Enhanced tumor invasiveness in ES2 cells was associated with CAF exosome-mediated, increased levels of N-cadherin and β-Catenin. Inhibition of CXCR4 expression or the Wnt/β-Catenin pathway of ES2 cells potentially reverses EMT and invasion induced by CAF exosomes.

Conclusion:
This study demonstrates that CXCR4-containing exosomes derived from CAFs could promote the EMT and invasion of OCCC.
Influence of Eco-friendly Pretreatment of Cellulose Acetate Fabric with
Laccase Enzyme on the Textile Properties, Dye Adsorption Isotherms, and
Thermodynamic Parameters
Authors: Zolriasatein Ali Akbar 
Published: December 2022

INTRODUCTION:
Deacetylation of cellulose acetate restores hydroxyl groups on the surface of fibers and improves hydrophilicity. From an environmental point of view, the conventional deacetylation process involves alkalinity and large effluent volume. The goal of this work is to introduce a new eco-friendly bio-treatment process.

METHOD:
In this study, cellulose acetate fabrics were bio-treated with laccase enzyme. Then, the untreated and bio-treated fabrics were dyed with direct and dispersed dyes. Laccase pretreatment improved color strength (16%) and crocking durability. After bio-treatment, the bending rigidity decreased for the warp (17.8) and weft (10.8) directions. The Freundlich model was the best model to describe the adsorption of direct dye onto the untreated fabric. In contrast, the Langmuir model better described the adsorption behavior of bio-treated fabric.

RESULT:
Nernst model was suitable for dispersed dye adsorption. The partition coefficient was increased after laccase treatment. Thermodynamic analysis showed that the dye sorption was endothermic and nonspontaneous.

CONCLUSION:
It was also found that bio-treated fabrics require less external energy. All performed experiments approved the efficiency of the deacetylation process, which led to an improvement in dyeing properties.
Using the Photostress method to determine the residual stresses
Authors: Alzyod Hussein , Ficzere Peter 
Published: December 2022

Strains and stresses in loaded and photoelastically coated structural members can be determined using the PhotoStress method. The quantitative values of variations in the principal strains (stresses) and their directions could be employed to get the strain or stress components field on the entire coated surface. In the PhotoStress experiment, isochromatic fringes give qualitative and quantitative information. It provides a source of information on the directions and magnitudes of principal strain and principal normal stress on the surface of photoelastic coated parts. This article reviews the principle of using PhotoStress analysis to measure the residual stress and provides the boundary condition of using this method.
Identification of Key Factors for Optimized Health Care Services: Protocol for a Multiphase Study of the Dubai Vaccination Campaign
Authors: Faroun Hayette , Zary Nabil , Baqer Khalifa , Alkhaja Farida , Gad Kareem , Alameddine Mohamad , Al Suwaidi Hanan 
Published: December 2022

Background
Mass vaccination of the global population against the novel COVID-19 outbreak posed multiple challenges, including effectively administering millions of doses in a short period of time while ensuring public safety and accessibility. The government of Dubai launched a mass campaign in December 2020 to vaccinate all its citizens and residents, targeting the population aged >18 years against COVID-19. The vaccination campaign involved a transformation of multiple commercial spaces into mass vaccination centers across the city of Dubai, the largest of which was the Dubai One Central (DOC) vaccination center. It was operational between January 17, 2021, and 27 January 27, 2022.

Objective
The multiphase research study aims to empirically explore the opinions of multiple health care stakeholders, elicit the key success factors that can influence the effective delivery of emergency health care services such as a COVID-19 mass vaccination center, and explore how these factors relate to one another.

Methods
To understand more about the operations of the DOC vaccination center, the study follows a multiphase design divided into 2 phases. The study is being conducted by the Institute for Excellence in Health Professions Education at Mohammed Bin Rashid University of Medicine and Health Sciences between December 2021 and January 2023. To elicit the key success factors that contributed to the vaccination campaign administered at DOC, the research team conducted 30 semistructured interviews (SSIs) with a sample of staff and volunteers who worked at the DOC vaccination center. Stratified random sampling was used to select the participants, and the interview cohort included representatives from the management team, team leaders, the administration and registration team, vaccinators, and volunteers. A total of 103 people were invited to take part in the research study, and 30 agreed to participate in the SSIs. To validate the participation of various stakeholders, phase 2 will analytically investigate one’s subjectivity through Q-methodology and empirically investigate the opinions obtained from the research participants during phase 1.

Results
As of July 2022, 30 SSIs were conducted with the research participants.

Conclusions
The study will provide a comprehensive 2-phase approach to obtaining the key success factors that can influence the delivery of high-quality health care services such as emergency services launched during a global pandemic. The study’s findings will be translated into key factors that could support designing future health care services utilizing evidence-based practice. In line with future plans, a study will use data, collected through the DOC vaccination center, to develop a simulation model outlining the process of the customer journey and center workflow.

International Registered Report Identifier (IRRID)
DERR1-10.2196/42278
Barriers and Facilitators of Obtaining Social Determinants of Health of Patients With Cancer Through the Electronic Health Record Using Natural Language Processing Technology: Qualitative Feasibility Study With Stakeholder Interviews
Authors: Alpert Jordan , Kim Hyehyun (Julia) , McDonnell Cara , Guo Yi , George Thomas J , Bian Jiang , Wu Yonghui 
Published: December 2022

Background
Social determinants of health (SDoH), such as geographic neighborhoods, access to health care, education, and social structure, are important factors affecting people’s health and health outcomes. The SDoH of patients are scarcely documented in a discrete format in electronic health records (EHRs) but are often available in free-text clinical narratives such as physician notes. Innovative methods like natural language processing (NLP) are being developed to identify and extract SDoH from EHRs, but it is imperative that the input of key stakeholders is included as NLP systems are designed.

Objective
This study aims to understand the feasibility, challenges, and benefits of developing an NLP system to uncover SDoH from clinical narratives by conducting interviews with key stakeholders: (1) oncologists, (2) data analysts, (3) citizen scientists, and (4) patient navigators.

Methods
Individuals who frequently work with SDoH data were invited to participate in semistructured interviews. All interviews were recorded and subsequently transcribed. After coding transcripts and developing a codebook, the constant comparative method was used to generate themes.

Results
A total of 16 participants were interviewed (5 data analysts, 4 patient navigators, 4 physicians, and 3 citizen scientists). Three main themes emerged, accompanied by subthemes. The first theme, importance and approaches to obtaining SDoH, describes how every participant (n=16, 100%) regarded SDoH as important. In particular, proximity to the hospital and income levels were frequently relied upon. Communication about SDoH typically occurs during the initial conversation with the oncologist, but more personal information is often acquired by patient navigators. The second theme, SDoH exists in numerous forms, exemplified how SDoH arises during informal communication and can be difficult to enter into the EHR. The final theme, incorporating SDoH into health services research, addresses how more informed SDoH can be collected. One strategy is to empower patients so they are aware about the importance of SDoH, as well as employing NLP techniques to make narrative data available in a discrete format, which can provide oncologists with actionable data summaries.

Conclusions
Extracting SDoH from EHRs was considered valuable and necessary, but obstacles such as narrative data format can make the process difficult. NLP can be a potential solution, but as the technology is developed, it is important to consider how key stakeholders document SDoH, apply the NLP systems, and use the extracted SDoH in health outcome studies.
Tren pemberitaan sonokeling dalam portal berita daring di Indonesia
Authors: Riastiwi Indira , Damayanto I Putu Gede P. 
Published: December 2022

Introduction. It has never been a study on the news trend of rosewood in Indonesia. This study aimed to determine the trend of rosewood news in online news portals and to create a distribution map of rosewood planting locations in Indonesia.
Data Collection Method. Data were obtained by collecting online news related to rosewood from 2016‒2022. Data were compiled and analyzed descriptively. A distribution map of rosewood was made and superimposed with data from Global Biodiversity Information Facility.
Results and Discussions. The number of rosewood news in Indonesia on online news portals increased from 2016‒2022. The most topic of the news is criminal (illegal logging and distribution of woods), followed by the topic of economic (woods potential use), disasters (trees fallen), social (tree-planting movements), and political (wood distribution regulation), respectively. In Indonesia, rosewood was planted in Jambi, Lampung, West Java, Central Java, DI Yogyakarta, East Java, Bali, West Nusa Tenggara, and East Nusa Tenggara, which correspond to the areas of rosewood cultivation and distribution in Indonesia.
Conclusions. The number of rosewood news in Indonesia on online news portals increased from 2016‒2022, dominated by criminal topics. In Indonesia, rosewood was planted in southern Sumatra, Java, Bali, and Nusa Tenggara.
Development of the elderly health monitoring system through families and community health workers during the COVID-19 pandemic
Authors: Wicaksana Anggi Lukman , Hafidz Firdaus , Rosha Putri T , Susilaningrum Annisa Ryan , Ramadhani Anisah 
Published: December 2022

Elderly people have a high risk of severe and fatal COVID-19 condition. Controlling the risk factors among the elderly is important, but health service provision during outbreaks is challenging. The elderly need increased attention to be monitored for their health status routinely. The elderly must also adjust daily activities according to the COVID-19 protocols. This program aimed to provide a practical example of a feasible system to empower community health workers and families for monitoring health among the elderly. This study used quantitative and qualitative data to identify the problems and needs of elderly health monitoring in Caturtunggal, Sleman, Indonesia. Descriptive quantitative methods used secondary data from the Sleman Health and Demographic Surveillance System and elderly health checklists to identify the issues of non-communicable diseases (NCDs) before and during COVID-19. The community health workers were interviewed to explore the needs and feasibility of programs among the elderly. As much as 16% of Caturtunggal population is elderly. One-third are 60-65 years old (33.30%) and retired (30.60%). The most common NCDs were hypertension (25.60%), diabetes mellitus (13.30%), stroke and coronary heart disease (4.40% for each). Almost all elderly (88.89%) have health insurance. Health counselling, online consultation, and monitoring were agreed on after discussion with the community health workers. Serial consultations (COVID-19 protocol for elderly, regular self-monitoring, the national health insurance mobile application, and health services during the pandemic situation) were conducted through WhatsApp groups. Free counseling was provided throughout the program for the elderly care during the outbreak. The monitoring was achieved through the WhatsApp groups by delivering instructional photos or videos of physical activity, blood pressure measurements, dietary record and stress management. The elderly and families felt more confident to check their health status and reported the results. In conclusion, development of health monitoring system was conducted through health checklists. Family and community cadres were also involved to make the program more feasible and sustainable.
Relationship of vegetable and fruit consumption with farmers' blood sugar levels in Pakusari Health Center, Jember
Authors: Fatimah Ayu Pricilia , Susanto Tantut , Susumaningrum Latifa Aini , Kholidi Mokhlas 
Published: December 2022

Low consumption of vegetables and fruits are one of the causes of digestive problems, coronary heart disease, and diabetes. Farmers are a vulnerable group for consuming vegetables and fruit less than the recommended 5 portions (250 grams) a day. The aim of this study was to analyze the relationship between vegetable and fruit consumption and the level of blood sugar among farmers with non-communicable diseases in the integrated health post (Posbindu) of Pakusari Health Center, Jember Regency. A retrospective cohort study design was used to analyze secondary data of Posbindu registered patients from January to March 2020 among 140 farmers. The characteristics of participants, vegetable and fruit consumption, and blood sugar were measured through the monitoring card of Posbindu. The data were analyzed using Chi-square tests (p-value <0.05). Among 140 farmers as many as 71.4% were identified who consumed vegetables and fruit less than 5 portions a day and 35.7% who have hyperglycemia. There was a relationship between vegetable and fruit consumption and the farmer's blood sugar level (p-value: <0.001; χ2: 13.144). Farmers who consumed vegetables and fruits less than 5 portions a day were 5 times more likely to experience hyperglycemia (RR:5.727; 95% CI=2.072–15.827). Therefore, community health nurses and health care providers should provide counseling to improve the consumption of vegetables and fruits to prevent the incidence of hyperglycemia among farmers.
El tumbadillo en Amaicha del Valle. Aproximaciones a las dimensiones de análisis de una práctica constructiva
Authors: Otegui Florencia , Dorado Pablo , Rolón Guillermo 
Published: December 2022

Tumbadillo is the layer of earthen ceiling that is applied to the underside of the mud (torta de barro) rooves characteristic of some regions of northwest Argentina and frequently found in Amaicha del Valle. Examining tumbadillo simply as a construction technique restricts interpretation of the social implications and production dynamics involved in its complex construction. To overcome this limitation, we use the concept of construction practice and address its complexity holistically. The two-fold objective of this work is to explore the tumbadillo as a construction practice and to define the dimensions of the analysis more precisely. The study involved participant observation of this construction practice and open, semi-structured interviews. By disaggregating analysis of the tumbadillo ceiling into a series of dimensions, researchers identified the logic and social practices associated with this construction practice and the reasons it remains relevant despite falling demand.
Analisis Belanja Daerah dan Fenomena Flypapereffect Kabupaten/Kota di Provinsi Jawa Timur
Authors: Alfatika Isma Nur , Susilowati Dwi 
Published: December 2022

The purpose of this study is to analyze the basic economic sector, classify the regional spending and the phenomena flypapereffect of city/district goverment in East Java for a 5 year period from 2016-2020. The method used is to use panel data regression by using secondary data sourced from regional financial and asset management office in 9 Cities in East Java Province. The results of the research based on the panel data regression is balancing funds and regional original income have a positive effect on regional spending and experience phenomena flypapereffect as evidenced by the large value of the balancing fund coefficient compared to local revenue.

Tujuan dari penelitian ini adalah untuk menganalisis sektor ekonomi dasar, mengklasifikasikan belanja daerah dan fenomena flypaper effect pemerintah kota/kabupaten di Jawa Timur selama periode 5 tahun dari tahun 2016-2020. Metode yang digunakan adalah menggunakan regresi data panel dengan menggunakan data sekunder yang bersumber dari Dinas Keuangan dan Pengelolaan Aset Daerah di 9 Kota di Provinsi Jawa Timur. Hasil penelitian berdasarkan regresi data panel adalah dana perimbangan dan pendapatan asli daerah berpengaruh positif terhadap belanja daerah dan mengalami fenomena flypapereffect yang dibuktikan dengan besarnya nilai koefisien dana perimbangan dibandingkan dengan pendapatan asli daerah.
Dampak Covid-19 Terhadap Pendapatan Pedagang di Pantai Lombang di Kabupaten Sumenep Provinsi Jawa Timur
Authors: Setiawati Febrika Melly , Arifin Zainal , Sari Novi Primita 
Published: December 2022

This study aims to determine the income level of street vendors during Covid-19 in Batang-Batang District, Sumenep Regency. This study uses a quantitative descriptive type of research in which the data obtained are in the form of information, both numbers and information orally and in writing. The data used includes two parts, namely primary and secondary data where primary data is data taken directly from business actors related to this researcher, while secondary data is data obtained through documentation of research objects in the form of written reports related to research. from the results of the study, it was found that the presence of covid-19 had a very large impact on traders, namely by decreasing the income of street vendors in the beach tourism area of ​​Lombang.

Penelitian ini bertujuan untuk mengetahui tingkat pendapatan pedagang kaki lima saat Covid-19 di Kecamatan Batang-batang Kabupaten Sumenep. Penelitian ini menggunakan jenis penelitian deskriptif kuantitatif yang dimana data yang diperoleh berbentuk keterangan baik angka dan maupun informasi secara lisan dan tulisan. Data yang digunakan meliputi dua bagian yaitu data primer dan sekunder yang dimana data primer merupakan data yang diambil langsung dari pelaku usaha yang berhubungan dengan peneliti ini, sedangkan data sekunder merupakan data yang didapatkan melalui dokumentasi objek penelitian berupa laporan tertulis yang berhubungan dengan penelitian.dari hasil penelitian didapatkan bahwa dengan adanya covid-19 memberikan dampak yang sangat besar terhadap pedagang yaitu dengan turunnya pendapatan para pedagang kaki lima di kawasan wisata pantai lombang.
Analisis Dampak Pertumbuhan Usaha Mikro Terhadap Kesejahteraan Masyarakat di Kabupaten Pasuruan
Authors: Haryani Ariska Dwicahyani 
Published: December 2022

This study aims to determine how the influence of micro-enterprise growth on the welfare of the community in Pasuruan Regency and to find out which micro-enterprise sector has the greatest impact on community welfare in Pasuruan Regency. In this study, the author uses a quantitative approach. Quantitative research is a research method based on the philosophy of positivism, used for research with a certain population or sample, data collection using research instruments, statistical data analysis with the aim of testing the established hypothesis. In this study, researchers took a sample of 30% of the districts in Pasuruan Regency, namely Bangil, Pandaan, Prigen, Purwodadi, Purwosari, Tutur, Sukorejo. The results showed that the growth of micro-enterprises in Pasuruan Regency affected and had a positive impact on the level of community welfare in Pasuruan Regency.

Penelitian ini bertujuan untuk mengetahui bagaimana pengaruh pertumbuhan usaha mikro terhadap kesejahteraan masyarakat di Kabupaten Pasuruan dan untuk mengetahui sektor usaha mikro mana yang paling besar pengaruhnya terhadap kesejahteraan masyarakat di Kabupaten Pasuruan. Dalam penelitian ini, penulis menggunakan pendekatan kuantitatif. Penelitian kuantitatif adalah metode penelitian yang didasarkan pada filosofi positivisme, digunakan untuk penelitian dengan populasi atau sampel tertentu, pengumpulan data menggunakan instrumen penelitian, analisis data statistik dengan tujuan menguji hipotesis yang telah ditetapkan. Dalam penelitian ini peneliti mengambil sampel 30% kecamatan yang ada di Kabupaten Pasuruan yaitu Bangil, Pandaan, Prigen, Purwodadi, Purwosari, Tutur, Sukorejo. Hasil penelitian menunjukkan bahwa pertumbuhan usaha mikro di Kabupaten Pasuruan mempengaruhi dan berdampak positif terhadap tingkat kesejahteraan masyarakat di Kabupaten Pasuruan.