bluuebunny/crossref_metadata_2025_split huggingface dataset:
The effects of the ‘Our Love, Our Control’ online program on sexual health literacy (SHL) and behaviors in preventing unintended pregnancy and sexually transmitted diseases (STDs) among adolescents in agricultural areas during COVID-19 outbreak in Thailand
Authors: Thongnopakun Saowanee , Manwong Mereerat , Rodjarkpai Yuvadee , Wattanaburanon Aimutcha , Visanuyothin Sawitree 
Published: August 2022

Background: This quasi-experimental study aimed to determine the effects of the ‘Our Love, Our Control’ online program on sexual health literacy and behaviors during the COVID-19 situation in Thailand from February 2020 to September 2021. Methods: Multistage sampling resulted in 37 and 34 participants in the experimental and control groups, respectively. Data were collected by a self-administered questionnaire. Descriptive statistics, Fisher’s exact test/Chi-square test, and independent t-test/Mann-Whitney test were used to determine differences in sociodemographic variables between the experimental and control groups. Repeated measures of ANCOVA were used to compare the mean and 95% confidence intervals of the adjusted variables. Results: From the results, adolescents who had sexual intercourse experience had statistically significant differences at the eighth week of score for behaviors (23.92; 95% CI: 16.56; 31.29), and at the eighth and at the twentieth week of score for sexual health literacy (43.55; 95% CI: 28.10; 59.00; and 19.35; 95% CI: 0.23; 38.48, respectively). However, adolescents who had no sexual intercourse experience had statistically significant differences only at the eighth week of score for sexual health literacy. (11.20; 95% CI: 3.79; 18.61). Conclusions: These findings present a useful practical program to prevent unintended pregnancy and sexually transmitted diseases, especially in sexually active adolescents.
Prevalence of COVID-19 vaccine hesitancy in students: A global systematic review
Authors: Roy Debendra Nath , Hossen Md. Mohabbot , Biswas Mohitosh , Islam Ekramul , Azam Md.Shah 
Published: August 2022

Background: Examining the prevalence of coronavirus disease (COVID-19) vaccine hesitancy and understanding what motivates students to accept or reject a newly promoted vaccine has the potential in preventing rapid spread of infection and optimizing country-wide mass vaccination programs. This systematic review aimed to examine global COVID-19 vaccine hesitancy among students, and to identify an up-to-date and concise assessment of most common factors influencing vaccine acceptance and hesitancy around the world. Methods: A systematic search of peer-reviewed literatures indexed in reputable databases was performed. After obtaining the results via screening using PRISMA flow diagram, a total of 35 articles met the inclusion criteria and formed the basic structure of the study objectives. Results: The results revealed that, the worldwide pooled COVID-19 vaccine hesitancy rate was (x̅%)=29.8% (95% CI 23.37–36.23) among students. According to the country count assessment, the pooled vaccine hesitancy has been found to be ups and downs across the countries around the world such as (x̅%)=32% (95% CI 20.04–43.97) in Asia, (x̅%)=(28.11%, 95% CI 18.83–37.40) in the United States, (x̅%)=15.59% (95% CI 8.23–22.95) in Europe, (x̅%)=55.93% (95% CI 40.31–71.55) in Africa, (x̅%)=20.4% in North America, and (x̅%)=22.5% in multi-ethnic areas in the reported student’s COVID-19 vaccine hesitancy. In total, 10 key factors were identified. “Side effect” 45.41% (95% CI 29.68–61.14), “safety” 42.27% (95% CI 27.50–57.04), and “trust” 44.95%, (95% CI 26.51–63.39) were the overarching concerns in making students' vaccination decisions. Conclusions: The prevalence of COVID-19 vaccine hesitancy varied among the students; however, vaccine acceptance or refusal relies on several socio-psychological, societal, and vaccine related factors. This study helps the vaccine policy-makers and health stakeholders gain a better understanding of COVID-19 vaccination drive and design the vaccine promotion strategies. Health educational interventions could be the most preferred approach to improve student’s adherence and knowledge about the COVID-19 vaccination consequences.
Mathematical model analysis and numerical simulation of intervention strategies to reduce transmission and re-activation of hepatitis B disease
Authors: Asfaw Wodajo Firaol , Tibebu Mekonnen Temesgen 
Published: August 2022

Background: Because of its asymptomatic nature, the Hepatitis B Virus (HBV) has become the most lethal and silent killer. In this research, we offer HBV virus transmission characteristics in the form of a mathematical model. We suggested and examined a seven-compartment compartmental nonlinear deterministic mathematical model for transmission dynamics with immigration and HBV reactivation after recovery, as well as control measures for Hepatitis B virus disease transmission. By considering the following facts and cases, this work will provide new knowledge. First, re-infection of HBV after liver transplantation, chemotherapy, and other therapies is one of the most essential aspects in HBV transmission, although reactivation of HBV was not taken into account in some compartmental models of HBV transmission. Furthermore, the exposure rate, immigration rate, and level of infectiousness of the chronic infective class were not given enough weight in the numerical assessment of the force of HBV infection. These facts influenced the development of our model. Methods: We demonstrated that the solution of the dynamical system under consideration is positive and bounded. The effective reproductive number that represents the epidemic indicator is generated from the biggest eigenvalue of the netgeneration matrix, and the model is examined qualitatively using differential equation stability theory. For disease-free and endemic equilibria, both local and global asymptotic stability criteria are determined. Results: A full explanation of the parameters and their numerical findings is presented and debated well based on the numerical simulation. Conclusions: According to the findings of this study, vaccination and treatment interventions play a critical role in reducing HBV transmission and reproduction. It has also been demonstrated that HBV reactivation contributes significantly to an increase in theinfective population, which boosts virus transmission, and that a combination of vaccination and treatment will be the most effective strategy for controlling HBV infection and reinfection after recovery.
Potential for Paramedic roles in Irish General Practice: A qualitative study of stakeholder’s perspectives
Authors: Barry Tomás , Batt Alan , Agarwal Gina , Booker Matthew , Casey Mary , McCombe Geoff 
Published: August 2022

Background: Irish health policy emphasises the role of Primary Care and General Practice however, there is a growing shortage of General Practitioners (GPs) in Ireland. Paramedics have traditionally focused on emergency care in the community. More recently Paramedics have taken on roles in General Practice in international jurisdictions, but not yet in Ireland. This study aimed to explore key stakeholder perceptions of ‘the potential for Paramedic roles in Irish General Practice’. Methods: We conducted an exploratory, qualitative stakeholder consultation study incorporating in-depth semi structured telephone interviews followed by thematic analysis. Interviews were conducted with a total of eighteen participants that included six senior Paramedics (Advanced Paramedics), seven General Practitioners (GPs), three Practice Nurses and two Practice Managers. Results: Participants in this study expressed polarised views on the potential for Paramedic roles in Irish General Practice. Paramedics were enthusiastic, highlighting opportunity for professional development and favourable working conditions. GPs, Practice Nurses and Managers were more circumspect and had concerns that Paramedic scope and skillset was not currently aligned to General Practice care. GPs, Practice Nurses and Managers emphasised a greater role for expanded General Practice Nursing. There were varied perceptions on what the potential role of a Paramedic in General Practice might entail, but consensus that Government support would be required to facilitate any potential developments. Conclusions: The findings of this research can inform future development of novel roles in Irish General Practice and suggests that there is appetite from within the Paramedic profession to pursue such roles. A pilot demonstration project, grounded in an action research framework could address data gaps and potential concerns. Any future developments should occur in tandem with and with due consideration for the expansion of General Practice Nursing in Ireland.
Impact of coronavirus disease (COVID-19) pandemic on physical activity of patients with cardiac implantable electronic devices—A remote monitoring study
Authors: Huttelmaier Moritz T. , Gabel Alexander , Seewald Maria , Jungbauer Carsten , Frantz Stefan , Störk Stefan , Fischer Thomas H. 
Published: August 2022

Objectives
The study aims to investigate the impact of COVID-19 pandemic on physical activity and frequency of implantable cardioverter-defibrillator (ICD) therapies of patients with cardiac implantable electronic devices.

Methods and results
Physical activity, heart rate and ICD-therapies were assessed via routine remote monitoring over two years. We focussed on a 338-day period during COVID-19 pandemic that was divided in 6 time-intervals defined by public health interventions and compared to the previous regular year. Paired nonparametric longitudinal analysis was performed to detect differences between time-intervals. To model effects of age, sex and time we applied a nonparametric ANOVA-type-statistic. 147 patients with cardiac implantable electronic devices were analysed. Longitudinal analysis of physical activity in 2019 and 2020 showed a specific weekly and seasonal pattern. Physical activity was reduced during the pandemic (mean daily physical activity 2019: 12.4% vs. 2020: 11.5%; p<0.0001) with the strongest reductions (fold changes 0.885/0.889, p<0.0001/p<0.0001) during the two lockdown-periods. In older patients (>70 years), physical activity was decreased in every time-interval of the year 2020. In time-intervals of eased restrictions, physical activity of younger patients (≤70 years) was not different compared to 2019. No variation in mean heart rate, arrhythmia-burden and count of ICD-therapies was found.

Conclusion
Physical activity shows fluctuations dependent on days of the week and time of the year. During the pandemic, physical activity was reduced in patients with cardiac implantable electronic devices with the strongest reductions during lockdown-periods. Younger patients resumed former levels of physical activity in times of eased restrictions while older patients remained less active. Thus, activation of the elderly population is important to prevent long-term health impairments due to the pandemic.
Timely administration of tocilizumab improves outcome of hospitalized COVID-19 patients
Authors: Rutgers Abraham , Westerweel Peter E. , van der Holt Bronno , Postma Simone , van Vonderen Marit G. A. , Piersma Djura P. , Postma Douwe , van den Berge Maarten , Jong Eefje , de Vries Marten , van der Burg Leonie , Huugen Dennis , van der Poel Marjolein , Kampschreur Linda M. , Nijland Marcel , Strijbos Jaap H. , Tamminga Menno , Mutsaers Pim G. N. J. , Schol-Gelok Suzanne , Dijkstra-Tiekstra Margriet , Sidorenkov Grigory , Vincenten Julien , van Geffen Wouter H. , Knoester Marjolein , Kosterink Jos , Gans Reinold , Stegeman Coen , Huls Gerwin , van Meerten Tom 
Published: August 2022

Introduction
The aim of this study was to determine the efficacy of early tocilizumab treatment for hospitalized patients with COVID-19 disease.

Methods
Open-label randomized phase II clinical trial investigating tocilizumab in patients with proven COVID-19 admitted to the general ward and in need of supplemental oxygen. The primary endpoint of the study was 30-day mortality with a prespecified 2-sided significance level of α = 0.10. A post-hoc analysis was performed for a combined endpoint of mechanical ventilation or death at 30 days. Secondary objectives included comparing the duration of hospital stay, ICU admittance and duration of ICU stay and the duration of mechanical ventilation.

Results
A total of 354 patients (67% men; median age 66 years) were enrolled of whom 88% received dexamethasone. Thirty-day mortality was 19% (95% CI 14%-26%) in the standard arm versus 12% (95% CI: 8%-18%) in the tocilizumab arm, hazard ratio (HR) = 0.62 (90% CI 0.39–0.98; p = 0.086). 17% of patients were admitted to the ICU in each arm (p = 0.89). The median stay in the ICU was 14 days (IQR 9–28) in the standard arm versus 9 days (IQR 5–14) in the tocilizumab arm (p = 0.014). Mechanical ventilation or death at thirty days was 31% (95% CI 24%-38%) in the standard arm versus 21% (95% CI 16%-28%) in the tocilizumab arm, HR = 0.65 (95% CI 0.42–0.98; p = 0.042).

Conclusions
This randomized phase II study supports efficacy for tocilizumab when given early in the disease course in hospitalized patients who need oxygen support, especially when concomitantly treated with dexamethasone.

Trial registration
https://www.trialregister.nl/trial/8504.
„Hee Haw”. Performanse śpiewu i tekstów songów Nicka Cave’a z formacją The Birthday Party na płycie The Birthday Party (1980)
Authors: Tański Paweł 
Published: August 2022

W artykule podjęto próbę interpretacji aspektów performatywnych śpiewu i tekstów piosenek Nicka Cave’a oraz autorstwa gitarzysty Rowlanda Stuarta Howarda (1959–2009), a także Micka Harveya, Vincenta Eugene’a Craddocka (znanego jako Gene Vincent) i Billa Davisa (właściwie: William Douchette) z albumu śpiewającego pianisty z grupą The Birthday Party The Birthday Party (1980). Studium, wpisując się w nurt rock song lyrics studies, jest recepcyjnym śladem i refleksją nad początkami drogi twórczej wybitnego autora tekstów piosenek oraz kompozytora muzyki rockowej i wokalisty, obdarzonego interesującym głosem. Teza prezentowanej pracy jest następująca: pochodzący z Australii wokalista od pierwszych nagrań z zespołem The Boys Next Door (płyta Door, Door z roku 1979) pisze utwory o miłości, bólu i samotności, a przede wszystkim każdy kolejny krążek autora Into My Arms to zapis doświadczenia tęsknoty, nie inaczej jest zatem i w przypadku omawianego tutaj albumu, który wyraża żal i smutek – uczucia autora/piosenkarza, „ja” opowiadającego/śpiewającego, persony tekstowo-muzycznej, czy inaczej mówiąc – piosenkowego podmiotu performatywnego. Śpiew Nicka Cave’a można określić jako metaforę habitusu punkowych miniatur piosenkowych, będących tekstowymi i głosowymi ekspresjami buntu, w których dominuje ironia, konstytutywną zasadą poetyki tych utworów zaś jest groteska.
Identification of active compounds in Ophiopogonis Radix from different geographical origins by UPLC-Q/TOF-MS combined with GC-MS approaches
Authors: Zha Xiaoyu , Li Gaowen , Zhang Ling , Chen Qun , Xia Qing 
Published: August 2022

Abstract
Ophiopogonis Radix, also known as Maidong in Chinese, is largely produced in the Sichuan and Zhejiang provinces: “Chuan-maidong (CMD)” and “Zhe-maidong (ZMD),” respectively. This study aimed to distinguish and evaluate the quality of CMD and ZMD. In this study, the tubers of CMD and ZMD were investigated using UPLC-Q/TOF-MS, GC-MS, and LC-MS methods, respectively. Overall, steroidal saponins, homoisoflavonoids, amino acids, and nucleosides were quickly identified. Furthermore, multivariate statistical analysis revealed that CMD and ZMD could be separated. Moreover, CMD showed higher levels of 4-aminobutanoic acid, glycine, l-proline, monoethanolamine, and serine than ZMD. Besides, the levels of chlorogenic acid, traumatic acid, cytidine, cadaverine, pyridoxine 5-phosphate, glutinone, and pelargonidin 3-O-(6-O-malonyl-β-d-glucoside) were remarkably higher in ZMD than in CMD. Furthermore, these different constituents were mainly associated with galactose metabolism; starch and sucrose metabolism; cysteine and methionine metabolism; valine, leucine, and isoleucine biosynthesis; and glycerophospholipid metabolism. In general, these results showed many differences between the bioactive chemical constituents of Ophiopogon japonicus from different production areas, where ZMD performed better in the quality assessment than CMD, and that UPLC-Q/TOF-MS, GC-MS, and LC-MS are effective methods to discriminate medicinal herbs from different production areas.
Global weak solution of 3D-NSE with exponential damping
Authors: Benameur Jamel 
Published: August 2022

Abstract
In this paper, we prove the global existence of incompressible Navier-Stokes equations with damping

α

(

e

β
∣
u

∣

2

−
1

)

u

\alpha \left({e}^{\beta | u{| }^{2}}-1)u

, where we use the Friedrich method and some new tools. The delicate problem in the construction of a global solution is the passage to the limit in exponential nonlinear term. To solve this problem, we use a polynomial approximation of the damping part and a new type of interpolation between

L

∞

(

R

+

,

L

2

(

R

3

)

)

{L}^{\infty }\left({{\mathbb{R}}}^{+},{L}^{2}\left({{\mathbb{R}}}^{3}))

and the space of functions

f

f

such that

(

e

β
∣
f

∣

2

−
1

)

∣
f

∣

2

∈

L

1

(

R

+

×

R

3

)

\left({e}^{\beta | f{| }^{2}}-1)| f{| }^{2}\in {L}^{1}\left({{\mathbb{R}}}^{+}\times {{\mathbb{R}}}^{3})

. Fourier analysis and standard techniques are used.
Identity and heritage language learning: a case study of two mixed-heritage Korean university students in New Zealand
Authors: Park Mi Yung , Chung Katalina 
Published: August 2022

Abstract
This narrative case study examines the identity development of two mixed-heritage (Korean/White and Korean/Japanese) university students in relation to Korean as a heritage language (HL) in New Zealand. The narratives of the two participants (Mia and Hannah) revealed that they grew up with different levels of exposure to the HL, which impacted their HL proficiency, and experienced different struggles with identity construction. While Mia’s White appearance helped her explore multiple ethnic/cultural identities, Hannah was deemed completely non-White by White New Zealanders, assigned a minority “Asian” identity, and subjected to racial discrimination. The dominant group’s confusion about intra-race mixedness and perceptions of Hannah as non-mixed complicated her situation. Hannah had little access to a majority heritage (New Zealander) identity, but also found her specific heritage identities occluded by an imposed single (“Asian”) identity. Nonetheless, on entering university both participants showed a strong desire to embrace their Koreanness through HL education or socialization with coethnic peers. HL learning played a crucial role in their construction of mixed-heritage identity; for Mia, the HL was valuable social capital, while for Hannah, the HL was a means of claiming her ethnic identity. This study highlights the complexity and plurality of mixed-heritage identities and offers implications for educators.
Electrical tunable topological valley photonic crystals for on-chip optical communications in the telecom band
Authors: Qi Zhipeng , Hu Guohua , Deng Chunyu , Sun Hao , Sun Yaohui , Li Ying , Liu Bo , Bai Yu , Chen Shuaidong , Cui Yiping 
Published: August 2022

Abstract
On-chip optical communications are in increasingly demand for low-loss, small-footprint and power-efficient waveguiding solutions in the telecom band. However, most integrated optical circuits suffer from high propagation loss and low integration degree. Through manipulating the valley-dependent topological phase of light, we have experimentally demonstrated both robust optical transport and electrical modulation of lightwaves at telecom wavelengths in the valley photonic crystals. With the adoption of valley kink states, the 25 Gbit/s optical signal at 1550 nm is successfully transmitted through a highly twisted interface. Furthermore, an extreme high data rate of 100 Gbit/s is demonstrated with such topological waveguide by wavelength division multiplexing. The electrical tunability of the topological modulators based on thermo-optic effect is also verified, opening a novel route towards active valley kink photonic devices. Our study shows a great possibility of making use of the topological protection in building up high-speed datalinks on a chip.
Fluorescence-based thermometry for precise estimation of nanoparticle laser-induced heating in cancerous cells at nanoscale
Authors: Peltek Oleksii O. , Ageev Eduard I. , Talianov Pavel M. , Mikushina Anna D. , Epifanovskaya Olga S. , Dubavik Aliaksei , Veiko Vadim P. , Lepik Kirill , Zuev Dmitry A. , Timin Alexander S. , Zyuzin Mikhail V. 
Published: August 2022

Abstract
Photothermal therapy (PTT) has attracted increasing interest as a complementary method to be used alongside conventional therapies. Despite a great number of studies in this field, only a few have explored how temperatures affect the outcome of the PTT at nanoscale. In this work, we study the necrosis/apoptosis process of cancerous cells that occurs during PTT, using a combination of local laser heating and nanoscale fluorescence thermometry techniques. The temperature distribution within a whole cell was evaluated using fluorescence lifetime imaging microscopy during laser-induced hyperthermia. For this, gold nanorods were utilized as nanoheaters. The local near-infrared laser illumination produces a temperature gradient across the cells, which is precisely measured by nanoscale thermometry. This allows one to optimize the PTT conditions by varying concentration of gold nanorods associated with cells and laser power density. During the PTT procedure, such an approach enables an accurate determination of the percentages of apoptotic and necrotic cells using 2D and 3D models. According to the performed cell experiments, the influence of temperature increase during the PTT on cell death mechanisms has been verified and determined. Our investigations can improve the understanding of the PTT mechanisms and increase its therapeutic efficiency while avoiding any side effects.
Acrylamide; a neurotoxin in popcorns: a systematic review and meta-analysis
Authors: Abedini Amirhossein , Zirak Mohammad- Reza , Akbari Nader , Saatloo Naiema Vakili , Badeenezhad Ahmad , Sadighara Parisa 
Published: August 2022

Abstract
Acrylamide is a known neurotoxic compound for humans. Foods that have high concentrations of acrylamide need to be identified. One of the food products containing acrylamide is popcorn. Popcorn is an important source of snacks for children, especially students. The presented study is a systematic review and meta-analysis of the level of acrylamide in popcorn. The search was done in different databases with the keywords; acrylamide, popcorn, popped corn. 27 articles were found by searching various databases. After initial screening and full text evaluation, 8 articles were selected for systematic review and 6 articles for meta-analysis. The amount of acrylamide in this product was in the range of 1,017.7–106 μg/kg. Microwaved corn contains lower amounts of acrylamide than other methods of preparation. The type of popcorn also had an effect on the amount of acrylamide with Meta-regression. It was found that sweet popcorn contains higher amounts of acrylamide. The overall value of acrylamide concentration in popcorns was calculated to be 459.6 ± 220.3 μg/kg. This amount is high and requires measures to reduce the amount of acrylamide.