bluuebunny/crossref_metadata_2025_split huggingface dataset:
Determination of estrogens in human serum using a novel chemical derivatization–assisted liquid chromatography‐electrospray ionization‐tandem mass spectrometry method
Authors: Kang Chong‐Xin , Fan Ru‐Ting , Xiao Hua‐Ming , Wang Xian 
Published: June 2022

RationaleAssessing estrogen concentrations in biological systems can provide valuable information on physiological processes, which is crucial for the early diagnosis of many diseases. Because estrogens are present in the human body in low concentrations and in a wide dynamic range, analytical methods with high sensitivity and specificity are required for their determination in complex biological matrices.MethodsTo discover an appropriate derivatization reagent for estrogen mass spectrometry (MS) analysis, we compared five sulfonyl chloride derivatization reagents, namely 3‐methyl‐8‐quinolinesulfonyl chloride (MQSCl) and 8‐quinolinesulfonyl chloride (QSCl), 1‐methyl‐1H‐pyrazole‐4‐sulfonyl chloride, 1,2‐methyl‐imidazole‐5‐sulfonyl chloride, and dansyl chloride. By selecting the derivatization reagent with the best performance, we developed and validated a novel chemical derivatization–assisted‐liquid chromatography‐electrospray ionization‐tandem mass spectrometry (CD‐LC‐ESI‐MS/MS) method to simultaneously determine the concentrations of estrone, estradiol, and estriol (E1, E2, and E3) in human serum.ResultsIt was found that among the five investigated reagents, MQSCl‐derivatized estrogens presented the highest sensitivity using LC‐ESI‐MS/MS. Based on this discovery, MQSCl was chosen to derivatize the analyzed estrogens to assist LC‐ESI‐MS/MS analysis. The limit of quantification of E1, E2, and E3 was measured as 2.7, 4.6, and 5.1 pg/mL, respectively. Inter‐ and intra‐day precision, expressed as the coefficient of variation, was shown to be lower than 13.2% for all concentrations. The mean recovery was 72.4% overall, with good reproducibility at low, medium, and high concentrations in the calibration range.ConclusionsThe developed method was successfully applied to the quantitative determination of estrogens in clinical human serum from pediatric and adult women, demonstrating the suitability of estrogen analysis in the biological matrix at low concentration (pg/mL).
Greenhouse gas emissions and poverty alleviation nexus in the Economic Commission of West African States
Authors: Ngong Chi Aloysius , Onyejiaku Chinyere C. , Fonchamnyo Dobdinga Cletus , Forgha Njimanted Godfrey , Aloysius Njong Mom , Onwumere Josaphat Uchechukwu Joe 
Published: June 2022

AbstractThis paper investigates the nexus between greenhouse gas emissions and poverty alleviation in the Economic Commission of West African States between 1985 and 2020 applying autoregressive distributed lag and Granger causality techniques. The results reveal that carbon dioxide non‐significantly relates to gross domestic product per capita positively while nitrous oxide and foreign direct investment impacts gross domestic product per capita positively. Methane negatively impacts gross domestic product per capita. The governments should use conventions to regulate greenhouse gas emissions’ effects on environmental degradation regionally and globally. The study underscores that countries should diversify to cleaner energy sources. This would reduce greenhouse gas emissions in the atmosphere. Massive technological investment is required to mitigate the greenhouse gas emissions’ negative impacts on the environment which create poverty. This policy implication ensures environmental sustainability and reverses the ugly trend of greenhouse gas emissions on poverty.
Correlation between magnetic resonance imaging and histological lesions in a case of meningoencephalomyelitis secondary to Neospora caninum infection in a greyhound
Authors: Albertini Guillaume Marc , Stabile Fabio , Yaffy Dylan , Suárez‐Bonnet Alejandro , Uriarte Ane 
Published: June 2022

AbstractAn 11‐year‐old, male, neutered raw fed greyhound was presented for a 2‐week history of progressive non‐lateralised, non‐painful ambulatory paraparesis, deteriorating acutely to non‐ambulatory tetraparesis. Magnetic resonance imaging, cerebrospinal fluid analysis and polymerase chain reaction tests confirmed the diagnosis of meningoencephalomyelitis secondary to Neospora caninum infection. Despite treatment, the patient deteriorated and was euthanased. Postmortem examination revealed diffuse areas of necrotising encephalomyelitis, multifocal non‐suppurative encephalomyelitis and areas of necrotising non‐suppurative cerebellitis. N. caninum parasitic cysts could also be identified. This is the first case report of correlated histological features and magnetic resonance imaging of meningoencephalomyelitis secondary to N. caninum. This case report was presented as an online poster presentation at the online 33rd ESVN‐ECVN symposium.
Whether implicit attitudes exist is one question, and whether we can measure individual differences effectively is another
Authors: Sripada Chandra 
Published: June 2022

AbstractQuestions about measurement of individual differences in implicit attitudes, which have been the focus so far in this exchange, should be distinguished from more general questions about whether implicit attitudes exist and operate in our minds. Theorists frequently move too quickly from pessimistic results regarding the first set of questions to pessimistic conclusions about the second. That is, they take evidence that indirect measures such as the implicit association test (IAT) disappoint as individual difference measures and use it to (mistakenly) suggest that people do not in fact have implicit attitudes directed at stigmatized groups. In this commentary, I dissect this mistake in detail, drawing key lessons from a parallel debate that has unfolded in cognitive science about “conflict tasks” such as the Stroop task. I argue that the evidence overall supports a nuanced conclusion: Indirect measures such as the IAT measure individual differences in implicit attitudes poorly, but they—via distinct lines of evidence—still support the view that implicit attitudes exist.This article is categorized under:
Psychology > Theory and Methods
Literary Tombs and Archaeological Knowledge in the Twelfth-Century ‘Romances of Antiquity’
Authors: Howell Naomi 
Published: June 2022

AbstractThis chapter explores intertextual and intermedial encounters between imaginative literature and archaeological knowledge in Western Europe in the second half of the twelfth century. Several of the popular ‘romans d’antiquités’ from this period, such as the anonymous Roman d’Eneas (c. 1160), Benoît de Sainte-Maure’s Roman de Troie (c. 1165), and Heinrich von Veldeke’s Eneit (1170–1788), feature elaborate ekphrastic descriptions of the tombs of legendary heroes and warriors. Although the romances of antiquity are works of fiction, their descriptions of ancient burial practices reflect the influence of written accounts of actual tomb openings and exhumations in the preceding century. Thus, the description of the burial of Pallas in the Roman d’Eneas is partly modeled on the chronicler William of Malmesbury’s account of the discovery of the ‘real’ tomb of Pallas in Rome, c. 1045. Similarly, in the Roman de Troie, the tomb of Hector with its distinctive enthroned burial is based in part on accounts of the opening of the tomb of Charlemagne by Otto III in the year 1000. Reading these romances alongside their archaeological intertexts sheds new light on the complex historical awareness of these literary works and the interpretative communities that received them.
Occupational Therapy
Authors: Kwan Polly 
Published: June 2022

AbstractOccupational therapy aims to engage individuals in meaningful tasks to improve and maintain their performance and quality of life. At the Walker Unit, occupational therapists assist young people to increase their independence and overall mental wellbeing through practical daily activities in the home and community, and through sensory-based interventions. Sensory approaches facilitate self-regulation in regards to both physiological and emotional arousal. Young people with mental health problems also have unique sensory experiences and needs, which should be understood by clinicians and caregivers to promote a sensory supportive experience to aid their recovery. The Walker Unit has embraced the sensory framework, incorporating the use of sensory-based interventions into treatment and everyday living.
Food and Eating
Authors: Currell Kia , Kwan Polly 
Published: June 2022

AbstractThe Walker Unit recognises the role of good nutrition to help support a young person’s growth and mental health. An experienced dietician and chef work closely with patients, families and staff to ensure dietary needs and meal preferences are managed to support good mental and physical health. The multidisciplinary team at the Walker Unit have experience managing difficult and complex eating behaviours that can present along with severe mental illness. These include restrictive and avoidant eating behaviours, overeating and binge eating, compensatory behaviours following eating, poor eating routines, increased appetite and cardiometabolic side effects of some treatments. The Walker Unit team recognise that these complex eating behaviours may require management from different and often creative angles which require the skillset of a multidisciplinary team.
Nursing Care
Authors: Hoare Steve , Ho Stephen 
Published: June 2022

AbstractOf all professional groups, the nurses at the Walker Unit have, undoubtedly, the greatest contact with patients. Much of this contact is informal, through supervision of activities of daily living and unstructured time. Nursing staff are the guardians for maintaining environmental safety and undertake searches of young people returning to the unit and regular environmental searches to ensure young people have no access to implements used for self-harming. Responding to duress alarms and the emergency administration of parenteral medication is also a common occurrence. Various ways of coordinating care have been trialled. In an effort to increase the likelihood patients will interact with a familiar nurse, the Walker Unit presently organises the nursing workforce into three teams that are allocated specific patients.
Family Therapy
Authors: Sarmiento Karen , Feijo Isabelle 
Published: June 2022

AbstractThe hospitalisation of a young person, particularly over an extended period of time, inevitably impacts on the entire family. Prior to admission to the Walker Unit, the young person and their family will have typically engaged with several other inpatient services and will have been exposed to a range of psychological and pharmacological treatments, with mixed results. However when discharged into the same unchanged family milieu, a deterioration can occur resulting in rehospitalisation and the need for further intensive care. By the time families arrive at a Walker admission, they are probably suffering treatment fatigue due to the impact of long hospitalisation and the impact of chronic mental illness. This needs to be overcome.
Emergent neutrinos from heavy messengers
Authors: Anastasopoulos Pascal , Kiritsis Elias 
Published: June 2022

Abstract
Fermionic bound states (mesinos) of messengers can play the role of right-handed neutrinos and due to their heavy masses they can realize the seesaw mechanism providing light and heavy sterile neutrinos. We study simple models with a single mesino to present the proof of principle. We extend our analysis to three mesino states where after the seesaw mechanism, three light and several heavy sterile neutrinos are obtained.
Soft gluon resummation for associated squark-electroweakino production at the LHC
Authors: Fiaschi Juri , Fuks Benjamin , Klasen Michael , Neuwirth Alexander 
Published: June 2022

Abstract
We perform a threshold resummation calculation for the associated production of squarks and electroweakinos at the LHC to the next-to-leading logarithmic (NLL) accuracy. Analytical results for the process-dependent soft anomalous dimension and the hard matching coefficient are presented. The resummed results are matched to fixed-order predictions at next-to-leading order (NLO) in QCD, which are generalised to scenarios with non-universal squark masses and mixings. Numerically, the NLL contributions increase the total NLO cross section by 2% to 6% for squark masses ranging from 1 TeV to 3 TeV, respectively, and they reduce the dependence of the predictions on the factorisation and renormalisation scales from typically ±10% to below ±5%. Our NLO and NLO+NLL calculations have been implemented in the publicly available program Resummino.
Einfluss des Rauchens auf den Gastrointestinaltrakt
Authors: Popp Sabine , Mang Thomas , Scharitzer Martina 
Published: June 2022

Zusammenfassung
Hintergrund
Nikotin ist ein hochwirksames Suchtgift, das bei regelmäßiger Einnahme chronische oder unheilbare Erkrankungen und somit eine eingeschränkte Lebensqualität zur Folge haben kann.

Fragestellung
Das Ziel dieser Übersichtsarbeit besteht darin, mögliche gesundheitliche Folgen des Rauchens auf den Gastrointestinaltrakt aufzuzeigen und einen Überblick über raucherassoziierte neoplastische und nichtneoplastische gastrointestinale Erkrankungen zu geben.

Material und Methode
Anhand einer ausführlichen Literaturrecherche wird der aktuelle Wissensstand zu raucherassoziierten Folgen auf den Gastrointestinaltrakt dargestellt.

Ergebnisse
Rauchen ist ein wesentlicher Risikofaktor für die Entstehung neoplastischer und nichtneoplastischer Erkrankungen des gesamten Gastrointestinaltrakts. Diese weisen in der radiologischen Bildgebung allerdings keine spezifischen, raucherassoziierten Merkmale auf.

Schlussfolgerung
Die Kenntnis einer Raucheranamnese sowie möglicher Auswirkungen von Nikotin auf den Gastrointestinaltrakt können in der radiologischen Bildinterpretation hilfreich sein sowie die diagnostische Entscheidungsfähigkeit und Genauigkeit verbessern.
COVID-19 ethnic inequalities in mental health and multimorbidities: protocol for the COVEIMM study
Authors: Impara E. , Bakolis I. , Bécares L. , Dasch H. , Dregan A. , Dyer J. , Hotopf M. , Stewart R. J. , Stuart R. , Ocloo J. , Das-Munshi J. 
Published: June 2022

Abstract
Purpose
The COVID-19 pandemic may have exacerbated ethnic health inequalities, particularly in people with multiple long-term health conditions, the interplay with mental health is unclear. This study investigates the impact of the pandemic on the association of ethnicity and multimorbidity with mortality/service use among adults, in people living with severe mental illnesses (SMI).

Methods
This study will utilise secondary mental healthcare records via the Clinical Record Interactive Search (CRIS) and nationally representative primary care records through the Clinical Practice Interactive Research Database (CPRD). Quasi-experimental designs will be employed to quantify the impact of COVID-19 on mental health service use and excess mortality by ethnicity, in people living with severe mental health conditions. Up to 50 qualitative interviews will also be conducted, co-produced with peer researchers; findings will be synthesised with quantitative insights to provide in-depth understanding of observed associations.

Results
81,483 people in CRIS with schizophrenia spectrum, bipolar or affective disorder diagnoses, were alive from 1st January 2019. Psychiatric multimorbidities in the CRIS sample were comorbid somatoform disorders (30%), substance use disorders (14%) and personality disorders (12%). In CPRD, of 678,842 individuals with a prior probable diagnosis of COVID-19, 1.1% (N = 7493) had an SMI diagnosis. People in the SMI group were more likely to die (9% versus 2% in the non-SMI sample) and were more likely to have mental and physical multimorbidities.

Conclusion
The effect of COVID-19 on people from minority ethnic backgrounds with SMI and multimorbidities remains under-studied. The present mixed methods study aims to address this gap.
Adjacent cartilage tissue structure after successful transplantation: a quantitative MRI study using T2 mapping and texture analysis
Authors: Janacova Veronika , Szomolanyi Pavol , Kirner Alexandra , Trattnig Siegfried , Juras Vladimir 
Published: June 2022

Abstract
Objectives
The aim of this study was to assess the texture of repair tissue and tissue adjacent to the repair site after matrix-associated chondrocyte transplantation (MACT) of the knee using gray-level co-occurrence matrix (GLCM) texture analysis of T2 quantitative maps.

Methods
Twenty patients derived from the MRI sub-study of multicenter, single-arm phase III study underwent examination on a 3 T MR scanner, including a T2 mapping sequence 12 and 24 months after MACT. Changes between the time points in mean T2 values and 20 GLCM features were assessed for repair tissue, adjacent tissue, and reference cartilage. Differences in T2 values and selected GLCM features between the three cartilage sites at two time points were analyzed using linear mixed-effect models.

Results
A significant decrease in T2 values after MACT, between time points, was observed only in repair cartilage (p < 0.001). Models showed significant differences in GLCM features between repair tissue and reference cartilage, namely, autocorrelation (p < 0.001), correlation (p = 0.015), homogeneity (p = 0.002), contrast (p < 0.001), and difference entropy (p = 0.047). The effect of time was significant in a majority of models with regard to GLCM features (except autocorrelation) (p ≤ 0.001). Values in repair and adjacent tissue became similar to reference tissue over time.

Conclusions
GLCM is a useful add-on to T2 mapping in the evaluation of knee cartilage after MACT by increasing the sensitivity to changes in cartilage structure. The results suggest that cartilage tissue adjacent to the repair site heals along with the cartilage implant.

Key Points
• GLCM is a useful add-on to T2mapping in the evaluation of knee cartilage after MACT by increasing the sensitivity to changes in cartilage structure.
• Repair and adjacent tissue became similar to reference tissue over time.
• The results suggest that cartilage tissue adjacent to the repair site heals along with the cartilage implant.
The development of a minimum dataset for MRI reporting of anorectal fistula: a multi-disciplinary, expert consensus process
Authors: Iqbal Nusrat , Sackitey Charlene , Gupta Arun , Tolan Damian , Plumb Andrew , Godfrey Edmund , Grierson Catherine , Williams Andrew , Brown Steven , Maxwell-Armstrong Charles , Anderson Iain , Selinger Christian , Lobo Alan , Hart Ailsa , Tozer Phil , Lung Phillip 
Published: June 2022

Abstract
There are a range of sphincter-preserving procedures available to treat anorectal fistula, some of which can be precluded, or rendered more optimal by specific features of fistula anatomy. Magnetic resonance imaging (MRI) is the gold standard modality for assessing anorectal fistula. To maximise clinical utility, the MRI report should accurately describe these clinically relevant features. We aimed to develop a minimum dataset for reporting MRI of anorectal fistula, in order to improve the assessment and management of these patients. A longlist of 70 potential items for the minimum dataset was generated through systematic review of the literature. This longlist was presented to radiologists, surgeons and gastroenterologists in an online survey to understand the features that shape current clinical practice. The longlist and survey results were then presented to an expert consensus panel to generate the final minimum dataset through discussion and anonymous voting. The final minimum dataset details the general characteristics, features of the internal and external openings, path of the fistula through the sphincters and any associated extensions and collections that should be described in all MRI reports for anal fistula. Additional surgical and perianal Crohn’s disease subsets were developed to indicate the features that aid decision-making for these patients, in addition to a minimum dataset for the clinical request. This study represents a multi-disciplinary approach to developing a minimum dataset for MRI reporting of anal fistula, highlighting the most important features to report that can assist in clinical decision-making.

Key Points
• This paper recommends the minimum features that should be included in all MRI reports for the assessment of anal fistula, including Parks classification, number of tracts, features of the internal and external opening, path of the tract through the sphincters, the presence and features of extensions and collections.
• Additional features that aid decision-making for surgery or in the presence of Crohn’s disease have been identified.
• The items that should be included when requesting an MRI are specified.
Effects of onshore development and damselfish (Stegastes nigricans) on coral richness in Opunohu Bay and Cook’s Bay in Moorea, French Polynesia
Authors: Blanchette Allison , Spies Brenton , Eminhizer Shannon , Franco Nancy , Gu Kelly , Turba Rachel , Jacobs David 
Published: June 2022

AbstractThe fringing reefs in Opunohu Bay and Cook’s Bay in Moorea, French Polynesia are an important component of Moorea’s fringing reef system, as they comprise approximately 20% of the island’s perimeter. The two bays are assumed to have differing benthic communities due to differences in onshore land development and freshwater input, but observational studies of their benthic communities are rarely published. To address this information gap, we conducted a quadrat-based benthic survey to determine important drivers of coral spatial variation throughout the bays. Interestingly, we found that coral taxonomic richness and cover did not significantly vary between bays, and corals only declined at the sites nearest freshwater input. Instead, coral richness was significantly greater when the territorial herbivorous damselfishStegastes nigricanswas present. The majority of the corals we documented were relatively small (88% < 10 cm diameter), thus our results support a positive effect ofS. nigricanson young coral diversity.Stegastes nigricanscould potentially be creating a refuge inside their territories from scraper herbivores for many non-dominant corals, although other potential mechanisms and the context of these benefits warrant further investigation. We conclude that, on the fringing reefs of Moorea’s two major bays, spatial variation in coral richness is more strongly associated with patches ofS. nigricansterritories than larger-scale differences in onshore land development and distance from freshwater input.
CERVI: collaborative editing of raster and vector images
Authors: Bath Ulrike , Shekhar Sumit , Egbert Julian , Schmidt Julian , Semmo Amir , Döllner Jürgen , Trapp Matthias 
Published: June 2022

AbstractVarious web-based image-editing tools and web-based collaborative tools exist in isolation. Research focusing to bridge the gap between these two domains is sparse. We respond to the above and develop prototype groupware for real-time collaborative editing of raster and vector images in a web browser. To better understand the requirements, we conduct a preliminary user study and establish communication and synchronization as key elements. The existing groupware for text documents or presentations handles the above through well-established techniques. However, those cannot be extended as it is for raster or vector graphics manipulation. To this end, we develop a document model that is maintained by a server and is delivered and synchronized to multiple clients. Our prototypical implementation is based on a scalable client–server architecture: using WebGL for interactive browser-based rendering and WebSocket connections to maintain synchronization. We evaluate our work qualitatively through a post-deployment user study for three different scenarios. For quantitative evaluation, we perform a thorough performance measure on both client and server side, thereby identifying design recommendations for future concurrent image-editing software(s).