bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exploring patients’ and relatives’ needs following acute myocardial infarction—A qualitative study
Authors: Qin Hong , Bonderman Diana , Brunner Silvia , Großbichler Tamara , Scharinger Edeltraud , Mayer Hanna 
Published: July 2022

AbstractBackgroundFor patients after acute myocardial infarction, a gap exists in Austrian care in the early period following hospital discharge. The patients’ and their relatives’ perspectives are crucial for developing nursing interventions.ObjectiveTo investigate patients’ and their relatives’ experiences from the onset of acute myocardial infarction symptoms until the early period following hospital discharge.MethodsThis qualitative study used in-depth individual and couple interviews with acute myocardial infarction patients (n = 14) and their relatives (n = 7) for data collection and a phenomenological hermeneutical analysis method.ResultsFour phenomena, i.e., “Understanding of living with heart disease,” “Omnipresent anxiety,” “Being there for each other,” and “Being understood as an individual,” showed participants’ needs. “Understanding of living with heart disease” described the process participants underwent to understand coronary heart disease, including the sub-phenomena of “Perceiving having heart disease,” “Getting familiar with heart disease,” and “Living life against the backdrop of heart disease.” It implied the participants’ strong need to get information on disease causes at the individual level and reshape their lives after the event to ensure a normal life.ConclusionHealthcare professionals should involve patients and their relatives in care and provide communication based on their needs. Such endeavors may allow those affected to understand coronary heart disease and prepare for and adapt to the needed lifestyle changes. Nursing interventions that consider the four phenomena highlighted in this study may ensure enhanced care for those affected in their lives after acute myocardial infarction, improving nursing care quality.
Learning from Country to conceptualise what an Aboriginal curriculum narrative might look like in education
Authors: Burgess Cathie , Thorpe Katrina , Egan Suzanne , Harwood Valerie 
Published: July 2022

AbstractMissing from the Australian Curriculum is a coherent Aboriginal curriculum narrative that is legitimate in its own right, rather than an “add on” to other curriculum areas. We argue that in order to do this, teachers need to experience Country-centred learning led by local Aboriginal community members. From these experiences, teachers can build relationships and better understand local knowledges and practices to develop an Aboriginal curriculum narrative for their teaching. In an urban Australian university teacher education program, Learning from Country in the City (LFC), a largely non-Aboriginal cohort of preservice teachers participate in Aboriginal community–led learning outside the classroom and on Country. This paper is based on qualitative data from individual yarns and group yarning circles with ten Aboriginal community-based educators and 30 preservice teachers. From this data, a Learning from Country Framework (Burgess et al., Teachers and Teaching, forthcoming) was developed which emphasises (i) Country-Centred Relationships, (ii) Relating, (iii) Critical Engagement, and (iv) Mobilising. Through deep listening and truth telling processes, preservice teachers build confidence and relationships with Aboriginal people and Country, awaken their critical consciousness and explore processes to conceptualise an Aboriginal curriculum narrative for their teaching. Through deep listening to the cultural, historical, and socio-political narratives of place, learning occurs through being and doing. Aboriginal community-based educators highlight the significance of Country-centred knowledges and truth-telling processes to challenge settler-colonial narratives and the power dynamics that have silenced Aboriginal people.
Fusing the Poverty-Aware Paradigm with Public Health Approaches to Protect Children: a Case Study of an Israeli Social Services Department
Authors: Saar-Heiman Yuval 
Published: July 2022

AbstractThis article aims to explore the potential contribution of incorporating the Poverty-Aware Paradigm for Child Protection—a critical framework for child protection policy and practice—with public health approaches to protecting children. It focuses on one Israeli social services department that embraced the Poverty-Aware Paradigm as an overarching framework for all levels of practice and specifically in the context of child protection. Based on an in-depth case study of the department’s child protection practice, the findings outline and describe the primary, secondary, and tertiary services and interventions through which the department addresses child maltreatment. These services and interventions are explored in light of Higgins and colleagues’ conceptualization of the six core components of public health approaches to preventing child maltreatment. This exploration points to the compatibly of the two frameworks and suggests three potential contributions of the Poverty-Aware Paradigm to the development of a public health approach. First, it offers a holistic and critical framework that focuses on a multidimensional analysis of child maltreatment and makes it possible to link tertiary responses to primary-level interventions. Second, it provides a firm ethical foundation rooted in a commitment to resisting social oppression and standing by parents, children, and their relationships. Third, it infuses relational concepts and practices into the policy and practice of public health approaches.
Cocultured Schwann Cells Rescue Irradiated Pelvic Neuron Outgrowth and Increase Survival
Authors: Randolph Joshua T. , Pak Elena S. , McMains Jennifer C. , Koontz Bridget F. , Hannan Johanna L. 
Published: July 2022

ABSTRACTBackgroundProstatic radiation therapy (RT) leads to erectile dysfunction by damaging peri-prostatic pro-erectile nerves of the pelvic ganglion. Schwann cells (SC) facilitate neuronal repair after mechanical injury, however, their role in repair of pelvic neurons post-radiation hasn’t been explored.AimTo determine if SCs cocultured with primary pelvic neurons can rescue neuronal survival and growth after ex vivo RT.MethodsMajor pelvic ganglia (MPG) were collected from adult male Sprague-Dawley rats (n = 12) to isolate SCs. SCs received RT (0 or 8 Gy), were plated on coated coverslips and grown to confluence before the addition of neurons. Additional MPGs were irradiated (0 or 8 Gy) and digested to isolate pelvic neurons. Dissociated neurons were plated alone or atop SC-coated coverslips to create 6 experimental groups (n = 3/grp): (i) Control (CON) MPG, (ii) RT MPG, (iii) CON SC + CON MPG, (iv) CONSC + RT MPG, (v) RT SC + CON MPG, and (iv) RT SC + RT MPG. After 72 hours, coverslips were fixed and stained for beta-tubulin (neuron marker), S100 (SC marker), neuronal nitric oxide synthase (nitrergic marker), tyrosine hydroxylase (sympathetic marker), and terminal deoxynucleotidyl transferase dUTP nick-end labeling.OutcomesWe measured neurite length, branching, specific neuron populations and apoptosis.ResultsEx vivo RT decreased MPG neuron length, increased apoptosis and decreased nitrergic neurons in monoculture. Compared to all other groups, CON SC + RT MPG cocultures demonstrated increased neurite outgrowth (P &lt; .001). Neurite branching was decreased in the RT MPG + RT SC coculture, but unchanged in other cocultures. Groups containing RT MPG neurons exhibited increased apoptosis, but coculture with CON SC reduced the degree of RT-induced apoptosis (P &lt; .01). The number of tyrosine hydroxylase positive neurons was unchanged while nitrergic neurons were significantly lower in RT neurons and coculture with CON SCs was unable to prevent nitrergic loss.Clinical TranslationThese findings suggest that SCs may be an important target in prostate cancer patients with radiation-induced pelvic neuropathy to promote MPG neuron survival and neuronal repair after RT.Strengths and LimitationsThis is the first study to characterize the ex vivo ability of SCs to rescue pelvic nerve growth and survival. The study is limited by little supporting mechanistic molecular data and the need to confirm the ability of healthy SCs to promote pelvic neuron survival and repair following prostatic RT in vivo.ConclusionUnirradiated SCs partially mitigated RT-induced MPG apoptosis but did not affect the loss of nitrergic neuron populations suggesting that SCs promote irradiated MPG neuron survival and facilitate intrinsic repair functions.
A GENERALISATION OF A SUPERCONGRUENCE ON THE TRUNCATED APPELL SERIES
Authors: WANG XIAOXIA , YU MENGLIN 
Published: July 2022

AbstractRecently, Lin and Liu [‘Congruences for the truncated Appell series
$F_3$
and
$F_4$
’, Integral Transforms Spec. Funct.31(1) (2020), 10–17] confirmed a supercongruence on the truncated Appell series
$F_3$
. Motivated by their work, we give a generalisation of this supercongruence by establishing a q-supercongruence modulo the fourth power of a cyclotomic polynomial.
Meta-analysis of longitudinal neurocognitive performance in people at clinical high-risk for psychosis
Authors: Hedges Emily P. , See Cheryl , Si Shuqing , McGuire Philip , Dickson Hannah , Kempton Matthew J. 
Published: July 2022

AbstractPersons at clinical high-risk for psychosis (CHR) are characterised by specific neurocognitive deficits. However, the course of neurocognitive performance during the prodromal period and over the onset of psychosis remains unclear. The aim of this meta-analysis was to synthesise results from follow-up studies of CHR individuals to examine longitudinal changes in neurocognitive performance. Three electronic databases were systematically searched to identify articles published up to 31 December 2021. Thirteen studies met inclusion criteria. Study effect sizes (Hedges' g) were calculated and pooled for each neurocognitive task using random-effects meta-analyses. We examined whether changes in performance between baseline and follow-up assessments differed between: (1) CHR and healthy control (HC) individuals, and (2) CHR who did (CHR-T) and did not transition to psychosis (CHR-NT). Meta-analyses found that HC individuals had greater improvements in performance over time compared to CHR for letter fluency (g = −0.32, p = 0.029) and digit span (g = −0.30, p = 0.011) tasks. Second, there were differences in longitudinal performance of CHR-T and CHR-NT in trail making test A (TMT-A) (g = 0.24, p = 0.014) and symbol coding (g = −0.51, p = 0.011). Whilst CHR-NT improved in performance on both tasks, CHR-T improved to a lesser extent in TMT-A and had worsened performance in symbol coding over time. Together, neurocognitive performance generally improved in all groups at follow-up. Yet, evidence suggested that improvements were less pronounced for an overall CHR group, and specifically for CHR-T, in processing speed tasks which may be a relevant domain for interventions aimed to enhance neurocognition in CHR populations.
A lead figurine from Toprakhisar Höyük: magico-ritual objects in the Syro-Anatolian Middle Bronze Age
Authors: Akar Murat , Kara Demet 
Published: July 2022

AbstractThis article examines supra-regional trends in magico-ritual objects through a mould-made lead figurine in the form of a foundation peg found in a disturbed Early Bronze IVB to Middle Bronze I transitional deposit at Toprakhisar Höyük (Altınözü, Hatay). The stylised object is interpreted as a bull standing atop a peg, pointing to the adoption of hybrid Syro-Anatolian and Mesopotamian technological, iconographic and apotropaic values. It is suggested the object is ritual paraphernalia, likely in relation to the cult of the Storm God, used in a foundation ritual. Together with this peculiar metal product, the presence of other magico-ritual objects that point to northern Mesopotamian connections at the small hinterland site of Toprakhisar Höyük, on the outskirts of the Amuq valley, is considered to be a possible material reflection of new groups in the region, including Hurrians and Amorites, which contributed to the unity and regionality of the cults and rituals of Syro-Anatolian communities of the Middle Bronze Age.
The variable use of diacritics in synchronous computer-mediated French discourse: Replication research
Authors: Blattner Geraldine , Williams Lawrence 
Published: July 2022

AbstractThis study promotes replication research as a methodological approach that is needed in order to compare earlier and more recent analyses of digital discourse. When much of the existing research was conducted, the primary means of communication included the use of a computer keyboard, (presumably) less bandwidth, and fewer devices. However, with an increase of the range of device types, the study of diacritics deserves another look within the Digital Media landscape. The present study examines the variable use of diacritics in synchronous (i.e., real-time) French chat discourse. We have replicated a study with different data sets from the same chat corpus, which is composed of data from a European chat server. We have also compared the data from the 2008 half of the corpus to data from the same chat channels collected in 2016 (just over 60,000 words in each half of the corpus, which included a total of 7,569 tokens that were coded). Our analysis of the 2008 corpus showed that one main finding was not the same as ours (from a different part of the 2008 corpus). Moreover, a diachronic analysis (2008 vs. 2016) revealed reversed trends between the two age-based channels (i.e., 20s vs. 50s).
Old and New in Language Variation in French Digital Media: A Commentary
Authors: Fagyal Zsuzsanna 
Published: July 2022

Abstract/ExcerptPapers in this Special Issue fill a gap in French sociolinguistics by providing a coherent and yet diverse sample of empirical studies on a variety of structural aspects of French digital media. Collectively, their thematic focus reflects a traditional framing of language variation, well known from variationist sociolinguistics, correlating empirically observed phonological, morphological, and lexical patterns with social and linguistic variables, among them age, gender, and genre. In this commentary, I reflect on each paper’s unique contribution to recent sociolinguistic research on digital media, and the volume’s goal to examine socially conditioned variation in selected contexts of twenty-first-century digital writing in French.
Sound Velocity Measurements of B2‐Fe‐Ni‐Si Alloy Under High Pressure by Inelastic X‐Ray Scattering: Implications for the Composition of Earth's Core
Authors: Dominijanni S. , McCammon C. A. , Ohtani E. , Ikuta D. , Sakamaki T. , Ishii T. , Criniti G. , Dubrovinsky L. S. , Khandarkhaeva S. , Fedotenko T. , Glazyrin K. , Uchiyama H. , Fukui H. , Baron A. Q. R. 
Published: July 2022

AbstractElastic properties of B2‐Fe0.67Ni0.06Si0.27 (15 wt.% Si) alloy have been investigated by combined high‐resolution inelastic X‐ray scattering and powder X‐ray diffraction in diamond anvil cells up to 100 GPa at room temperature. Densities (ρ), compressional (VP) and shear (VS) wave velocities were extrapolated to inner core conditions to enable comparison with the preliminary reference Earth model. The modeled aggregate compressional and shear wave velocities and densities of the two‐phase mixture of B2‐Fe0.67Ni0.06Si0.27 and hcp‐Fe‐Ni are consistent with inner core PREM values of VP, VS, and ρ based on a linear mixing model with 30(5) vol % B2‐Fe0.67Ni0.06Si0.27 and 70(5) vol % hcp Fe‐Ni, which corresponds to ∼3–5 wt.% Si and ∼5–12 wt.% Ni.
Improved Modeling of Mars' HDO Cycle Using a Mars' Global Climate Model
Authors: Vals Margaux , Rossi Loïc , Montmessin Franck , Lefèvre Franck , Gonzalez‐Galindo Francisco , Fedorova Anna , Luginin Mikhail , Forget François , Millour Ehouarn , Korablev Oleg , Trokhimovskiy Alexander , Shakun Alexey , Bierjon Antoine , Montabone Luca 
Published: July 2022

AbstractHDO and the D/H ratio are essential to understand Mars past and present climate, in particular with regard to the evolution through ages of the Martian water cycle. We present here new modeling developments of the HDO cycle with the Laboratoire de Météorologie Dynamique Mars Global Climate Model (GCM). The present study aims at exploring the behavior of the D/H ratio cycle and its sensitivity to the modeling of water ice clouds and the formulation of the fractionation by condensation. Our GCM simulations are compared with observations provided by the Atmospheric Chemistry Suite (ACS) on board the ESA/Roscosmos Trace Gas Orbiter (TGO), and reveal that the model quite well reproduces the temperature and water vapor fields, which offers a good basis for representing the D/H ratio cycle. The comparison also emphasizes the importance of modeling the state of supersaturation, resulting from the microphysical processes of water ice clouds, to correctly account for the water vapor and the D/H ratio of the middle‐to‐upper atmosphere. This work comes jointly with a detailed comparison of the measured D/H profiles by TGO/ACS and the model outputs, conducted in the companion paper of Rossi et al. (2022, https://doi.org/10.1029/2022JE007201) (this issue).
Non‐Linear Dimensionality Reduction With a Variational Encoder Decoder to Understand Convective Processes in Climate Models
Authors: Behrens Gunnar , Beucler Tom , Gentine Pierre , Iglesias‐Suarez Fernando , Pritchard Michael , Eyring Veronika 
Published: July 2022

AbstractDeep learning can accurately represent sub‐grid‐scale convective processes in climate models, learning from high resolution simulations. However, deep learning methods usually lack interpretability due to large internal dimensionality, resulting in reduced trustworthiness in these methods. Here, we use Variational Encoder Decoder structures (VED), a non‐linear dimensionality reduction technique, to learn and understand convective processes in an aquaplanet superparameterized climate model simulation, where deep convective processes are simulated explicitly. We show that similar to previous deep learning studies based on feed‐forward neural nets, the VED is capable of learning and accurately reproducing convective processes. In contrast to past work, we show this can be achieved by compressing the original information into only five latent nodes. As a result, the VED can be used to understand convective processes and delineate modes of convection through the exploration of its latent dimensions. A close investigation of the latent space enables the identification of different convective regimes: (a) stable conditions are clearly distinguished from deep convection with low outgoing longwave radiation and strong precipitation; (b) high optically thin cirrus‐like clouds are separated from low optically thick cumulus clouds; and (c) shallow convective processes are associated with large‐scale moisture content and surface diabatic heating. Our results demonstrate that VEDs can accurately represent convective processes in climate models, while enabling interpretability and better understanding of sub‐grid‐scale physical processes, paving the way to increasingly interpretable machine learning parameterizations with promising generative properties.
Pathogenic fungus uses volatiles to entice male flies into fatal matings with infected female cadavers
Authors: Naundrup Andreas , Bohman Björn , Kwadha Charles A , Jensen Annette B , Becher Paul G , De Fine Licht Henrik H 
Published: July 2022

Abstract
To ensure dispersal, many parasites and pathogens behaviourally manipulate infected hosts. Other pathogens and certain insect-pollinated flowers use sexual mimicry and release deceptive mating signals. However, it is unusual for pathogens to rely on both behavioural host manipulation and sexual mimicry. Here, we show that the host-specific and behaviourally manipulating pathogenic fungus, Entomophthora muscae, generates a chemical blend of volatile sesquiterpenes and alters the profile of natural host cuticular hydrocarbons in infected female housefly (Musca domestica) cadavers. Healthy male houseflies respond to the fungal compounds and are enticed into mating with female cadavers. This is advantageous for the fungus as close proximity between host individuals leads to an increased probability of infection. The fungus exploits the willingness of male flies to mate and benefits from altering the behaviour of uninfected male host flies. The altered cuticular hydrocarbons and emitted volatiles thus underlie the evolution of an extended phenotypic trait.
Lomitapide, a cholesterol-lowering drug, is an anticancer agent that induces autophagic cell death via inhibiting mTOR
Authors: Lee Boah , Park Seung Ju , Lee Seulgi , Lee Jinwook , Lee Eunbeol , Yoo Eun-Seon , Chung Won-Suk , Sohn Jong-Woo , Oh Byung-Chul , Kim Seyun 
Published: July 2022

AbstractAutophagy is a biological process that maintains cellular homeostasis and regulates the internal cellular environment. Hyperactivating autophagy to trigger cell death has been a suggested therapeutic strategy for cancer treatment. Mechanistic target of rapamycin (mTOR) is a crucial protein kinase that regulates autophagy; therefore, using a structure-based virtual screen analysis, we identified lomitapide, a cholesterol-lowering drug, as a potential mTOR complex 1 (mTORC1) inhibitor. Our results showed that lomitapide directly inhibits mTORC1 in vitro and induces autophagy-dependent cancer cell death by decreasing mTOR signaling, thereby inhibiting the downstream events associated with increased LC3 conversion in various cancer cells (e.g., HCT116 colorectal cancer cells) and tumor xenografts. Lomitapide also significantly suppresses the growth and viability along with elevated autophagy in patient-derived colorectal cancer organoids. Furthermore, a combination of lomitapide and immune checkpoint blocking antibodies synergistically inhibits tumor growth in murine MC38 or B16-F10 preclinical syngeneic tumor models. These results elucidate the direct, tumor-relevant immune-potentiating benefits of mTORC1 inhibition by lomitapide, which complement the current immune checkpoint blockade. This study highlights the potential repurposing of lomitapide as a new therapeutic option for cancer treatment.
Targeting sphingosine kinase 1/2 by a novel dual inhibitor SKI-349 suppresses non-small cell lung cancer cell growth
Authors: Xue Yuhang , Jiang Kanqiu , Ou Li , Shen Mingjing , Yang Yi , Lu Jingjing , Xu Weihua 
Published: July 2022

AbstractSphingosine kinase 1 (SphK1) and sphingosine kinase (SphK2) are both important therapeutic targets of non-small cell lung cancer (NSCLC). SKI-349 is a novel, highly efficient and small molecular SphK1/2 dual inhibitor. Here in primary human NSCLC cells and immortalized cell lines, SKI-349 potently inhibited cell proliferation, cell cycle progression, migration and viability. The dual inhibitor induced mitochondrial depolarization and apoptosis activation in NSCLC cells, but it was non-cytotoxic to human lung epithelial cells. SKI-349 inhibited SphK activity and induced ceramide accumulation in primary NSCLC cells, without affecting SphK1/2 expression. SKI-349-induced NSCLC cell death was attenuated by sphingosine-1-phosphate and by the SphK activator K6PC-5, but was potentiated by the short-chain ceramide C6. Moreover, SKI-349 induced Akt-mTOR inactivation, JNK activation, and oxidative injury in primary NSCLC cells. In addition, SKI-349 decreased bromodomain-containing protein 4 (BRD4) expression and downregulated BRD4-dependent genes (Myc, cyclin D1 and Klf4) in primary NSCLC cells. At last, SKI-349 (10 mg/kg) administration inhibited NSCLC xenograft growth in nude mice. Akt-mTOR inhibition, JNK activation, oxidative injury and BRD4 downregulation were detected in SKI-349-treated NSCLC xenograft tissues. Taken together, targeting SphK1/2 by SKI-349 potently inhibits NSCLC cell growth in vitro and in vivo.