bluuebunny/crossref_metadata_2025_split huggingface dataset:
Тезаурус детства в социогуманитарных науках
Authors: Майорова-Щеглова Светлана Николаевна , Митрофанова Светлана Юрьевна 
Published: April 2022

<p>Тезаурус российского детства представлен в статье как постоянно меняющийся, активно наполняющийся новыми трендами. Приведена его характеристика через конструкты «фрагментарность» / «единство», «ядро» / «периферия», «традиция» / «парадоксальность». В качестве методологии исследования современного состояния тезауруса детства принимаются позиции Вал. А. Лукова об исходном конструирующем субъекте и тезаурусная гипотеза социализации А. И. Ковалевой.</p><p>Приводятся авторские аргументы о координирующей роли социологии детства в междисциплинарном синтезе различных наук о детстве. Исследование показало характеристики тезауруса детства, связанные со сложностью, динамичностью, перманентными изменениями социальной реальности и возникновением именно в детском сегменте новых явлений технологизации и гаджетизации жизни юных, дистанционного обучения и досуга, парадоксальности сосуществования одновременной глобализации и глокализации детства. Одним из выводов исследований детства является возможная интервенция тезауруса детства в тезаурус молодежи в связи с обнаруженными явлениями продления детства.</p>
«Ненужные» знания высшей школы: к проблеме конструирования тезауруса студенческой молодежью
Authors: Селиверстова Нина Анатольевна 
Published: April 2022

<p>В статье рассматривается феномен «ненужных» знаний высшей школы в связи с конструированием тезауруса студенческой молодежью. Автор приходит к выводу, что определение «“ненужные” знания» — это: 1) проявление инструментализации отношения студенческой молодежи к знанию и высшему образованию; 2) отсутствие познавательного интереса к конкретному знанию, дисциплине, отрасли науки; 3) оправдание недостаточных способностей и / или базы знаний для освоения конкретной дисциплины.</p><p>Субъектность студенческой молодежи при конструировании тезауруса выражается в отказе осваивать «ненужные знания», имитации образовательных практик. Проблема «ненужных» знаний рассматривается в контексте процесса гуманитаризации высшего образования, а также формирования «твёрдых» (hard skills) и «мягких» (soft skills) навыков студентов.</p>
Organizing the quality assessment in lung cancer care on the example of the Netherlands
Authors: Andreev D. A. , Zavyalov A. A. 
Published: April 2022

Introduction: In the Russian Federation and worldwide lung cancer (RL) is the leading malignancy. In order to improve the availability of modern diagnostic and treatment algorithms for a huge number of lung cancer patients, highly specialized audits of oncological care have been organized in many countries.Purpose: Reviewing the basic principles for organizing specialized national lung cancer care audits based on the example from the Netherlands.Materials and methods: The search for relevant articles was carried out in PubMed, as well as using the Google search engine. The search strings included keywords such as: «audit», «lung cancer», «Dutch», «the Netherlands» and many others.Results: Nowadays, the specialized Dutch audit for lung cancer relies on the sub‑registers devoted to the following topics: 1) medical practice of oncologists‑pulmonologists; 2) the activities of surgeons; 3) the work of radiation oncologists. Wide coverage of different treatment areas and digital integration provide a comprehensive picture of cancer care throughout all aspects of routing patients with RL in the Netherlands Selective sub‑audits are of great scientific and practical importance. Feedback systems, the latest digital technologies and a sufficient level of transparency ensure effective quality control of diagnostics and treatment of patients with lung cancer in the studied countries.Conclusion: Beneficial way to improve quality assurance is based on the use of complex, complementary principles of cognition, including holism, reductionism, induction methods, combinatorial analysis, etc. etc. Regardless of the implemented approaches to quality control, the cancer network should always remain focused on each single patient. The private interests of a particular patient, survival rate, quality of life with have determine the prioritized vector of innovative development of audits of oncological practice.
The Yuen’s Dimension-Based Cultural Diversities in the ELT Textbook For Senior High School Students
Authors: Setyawaningsih Sari Putri , Setyono Budi , Rofiq Annur 
Published: April 2022

The present study uses critical discourse analysis (CDA) to examine the representation of cultural diversities in the first year of senior high school English textbook published by a non-government publisher. Data of the present study are texts and pictures that represent cultural diversities in an Indonesian ELT textbook. The findings revealed that there are four cultural categories based on Yuen’s cultural dimensions (i.e product, practice, person, and perspective) coming from inner, outer, and expanding circle countries. The implication is that the visual materials must be balanced with the verbal materials.
Keywords: Critical discourse analysis, cultural diversities, ELT textbook, senior high school, Indonesia.
The Improving Students’ Vocabularies Using Newspapers as an Authentic Materials
Authors: Kalima'aza Zahwa Azwaza , Sukmaantara I Putu , Bindarti Wiwiek Eko 
Published: April 2022

Authentic material is the material that the contents and the language used is close to the students’ real life. Authentic materials have not been specifically produced for the purpose of language teaching and this easily differentiates it from textbook materials. In addition, the use of authentic materials is expected to bring students in direct contact with reality so that students are interested in the vocabulary learning process. This research aims to find out the use of the authentic materials; English newspapers in teaching vocabulary. The participants of this research are the eleventh grader of Muhammadiyah 2 Genteng Senior High School which consists of 31 students. The design of this research is classroom action research. There are two kinds of data collected by the researcher; primary and secondary data. The primary data were collected from the students’ observation, and vocabulary test, while the secondary data were collected from the result of interview, and documentation. In this research, the researcher found that in the first meeting, the students’ participation was 65% and in the second meeting was 84%. Moreover, the students’ vocabulary scores have improved from 61.29% to 87.097%. It can be concluded that the use of the authentic materials; English newspapers can improve the eleventh grade students’ vocabulary achievement.
Keywords: Authentic Materials, Vocabulary, Newspapers
Population genetics of the blueberry gall midge, Dasineura oxycoccana (Diptera: Cecidomyiidae), on blueberry and cranberry, with testing invasion scenarios
Authors: Kim Hyojoong , Rodriguez-Saona Cesar , Lee Heung-Sik 
Published: April 2022

Abstract
Native to North America, the blueberry gall midge, Dasineura oxycoccana (Johnson) (Diptera: Cecidomyiidae), is an economically important insect pest of blueberry and cranberry in its native range (USA and Canada) as well as in other parts of the world. Although two genetically distinct D. oxycoccana populations associated with blueberry and cranberry were previously reported, this needs to be revised through further population genetics approaches and a large sample size. Moreover, this pest was recently introduced and spread through other countries in North America, Europe, and Asia. In Korea, D. oxycoccana was first found about a decade ago and rapidly spread throughout the country. In this study, we compared the population genetic structure between D. oxycoccana populations from blueberry and cranberry and determined genetic relationships among geographical subgroups by genotyping 632 individuals from 31 different populations from the USA (New Jersey, Michigan, and Georgia) and Korea using 12 microsatellite loci. Our population genetic analyses showed a clear separation between the two host-associated D. oxycoccana populations from blueberry and cranberry. Using data from only the blueberry-associated D. oxycoccana populations, five genetically isolated subgroups were identified. Analysis of the approximate Bayesian computation suggests that the invasive D. oxycoccana population from Korea appears to have been introduced from an unsampled source population. Our findings will allow for an easier identification of the source of D. oxycoccana into newly invaded regions, as well as to determine their association with blueberry and cranberry, which based on our results can be considered as two distinct species.
Cloning and expression of recombinant human superoxide dismutase 1 (hSOD1) in Bacillus subtilis 1012
Authors: Liu Hongtao , Yin Mingzhu , Wang Nian , Wang Qiqi , Xia Hui , Cheng Xue , Hu Haiming , Zhang Zhigang 
Published: April 2022

Abstract
As an important member of the antioxidant defense system in vivo, human Cu, Zn superoxide dismutase (hSOD1) has become a potential therapeutic agent against host diseases, and new strategies were developed to achieve high-yield SOD1 by using efficient production systems, like E. coli, yeast, and other eukaryotic expression systems. However, the above systems have their own limitations, such as the formation of inclusion bodies, endotoxins production, and low secretion efficiency. In this study, the hSOD1 coding sequence gene was amplified from human HepG2 cells, cloned into a pHT43-His expression vector, and transformed into Bacillus subtilis system. After the optimization with different media, temperatures, and inducer (IPTG) concentrations, the recombinant hSOD1 was successfully expressed in Bacillus subtilis 1012. The results show that hSOD1 was produced as a soluble form in Super rich medium with 0.2 mM of IPTG at 37°C after the induction for 24 h. Besides, 20 g/L of lactose also displayed the same inductive effect on hSOD1 expression as that by 0.2 mM of IPTG. Finally, hSOD1 was efficiently purified by nickel affinity chromatography, and the specific activity of hSOD1 was determined to be 1625 U/mg in the presence of 800 µM of Cu2+ and 20 µM of Zn2+. Collectively, Bacillus subtilis 1012 can not only overcome the shortcomings of E. coli and yeast expression systems, but also be directly used for disease treatment as a healthy probiotic. These advantages provided a possibility for the application of oral engineering bacteria 1012-hSOD1 to the clinical treatment in the future.
Do low-level laser therapy and platelet-rich plasma affect bone calcium content and mechanical properties at tooth extraction sites? An experimental study in the rat
Authors: Sharifi Alireza , Talaei-Khozani Tahereh , Tanideh Nader , Zadeh Hossein Khaje , Haghighat Meysam , Pour Sheila Shahsavari , Tavanafar Saeid 
Published: April 2022

Abstract
Background: Both low-level laser therapy (LLLT) and platelet-rich plasma (PRP) have been suggested to improve the repair of mandibular defects. This study investigated the mechanical properties and calcium content at the tooth extraction site in the rat model exposed to LLLT (λ=808 nm) with or without PRP. Methods: In this experimental rat model, the maxillary left first molar teeth were extracted in twenty male rats. Then, they were divided randomly into four groups. Group one: the extraction sockets were treated by 0.9 W gallium-aluminum-arsenide (GaAlAs) diode laser irradiation for five minutes every 72 hours after extraction for the next 12 days (4 times in overall); group two: PRP was placed in the extraction sockets; group three: a combination of both treatments (LLLT+PRP) was done; group four: untreated extraction socket as the control group. All rats were sacrificed 30 days post-operative. All bone blocks of the extracted socket were prepared for mechanical strength and calcium content analyses. Results: The compressive strength in the laser group was significantly higher than in both the control and PRP-treated groups (p=0.0001 and 0.00044, respectively). Although a combination of both PRP and LLLT elevated the mechanical strength compared to the control and PRP groups, it was statistically similar to LLLT/PRP group. Calcium content did not change by any of the treatments. Conclusions: Mechanical and chemical analyses on the bone blocks demonstrated that LLLT improved bone healing; however, PRP alone or combined with LLLT did not show a synergistic impact.
Overexpression of Laminin-5 Gamma-2 promotes tumorigenesis of pancreatic ductal adenocarcinoma through EGFR/ERK1/2/AKT/mTOR cascade
Authors: Kirtonia Anuradha , Pandey Amit Kumar , Ramachandran Balaji , Mishra Durga Prasad , Dawson David W , Sethi Gautam , Ganesan Trivadi S , Koeffler H Phillip , Garg Manoj 
Published: April 2022

Abstract
Pancreatic ductal adenocarcinoma (PDAC) is correlated with poor outcomes because of limited therapeutic options. Laminin-5 Gamma-2 (LAMC2) plays a critical role in key biological processes. However, the detailed molecular mechanism and potential roles of LAMC2 in PDAC stay unexplored. The present study examines the essential role and molecular mechanisms of LAMC2 in the tumorigenesis of PDAC. Here, we identified that LAMC2 is significantly upregulated in microarray cohorts and TCGA RNA sequencing data of PDAC patients compared to non-cancerous /normal tissues. Patients with higher transcript levels of LAMC2 were correlated with clinical stages; dismal overall, as well as, disease-free survival. Additionally, we confirmed significant upregulation of LAMC2 in a panel of PDAC cell lines and PDAC tumor specimens in contrast to normal pancreatic tissues and cells. Inhibition of LAMC2 significantly decreased cell growth, clonogenic ability, migration and invasion of PDAC cells, and tumor growth in PDAC xenograft model. Mechanistically, silencing of LAMC2 suppressed expression of ZEB1, SNAIL, N-cadherin, vimentin, and induced E-cadherin expression leading to a reversal of mesenchymal to an epithelial phenotype. Interestingly, co-immunoprecipitation experiments demonstrated LAMC2 interaction with epidermal growth factor receptor (EGFR). Further, stable knockdown of LAMC2 inhibited phosphorylation of EGFR, ERK1/2, AKT, mTOR, P70S6 kinase signaling cascade in PDAC cells. Altogether, our findings suggest that silencing of LAMC2 inhibited PDAC tumorigenesis and metastasis through repression of epithelial-mesenchymal transition and modulation of EGFR/ERK1/2/AKT/mTOR axis and could be a potential diagnostic, prognostic, and therapeutic target for PDAC.
Tidal power station at sea
Authors: Huang Junqiang 
Published: April 2022

Abstract
Tidal energy is a cleaning resource made by the moon, it is one of the best ways for human beings to save the earth from the devastating consequences of global warming.Now climate change is a big problem to us, we should look for some good green energy to prevent global warming, we should work hard to preserve our planet. If not so, no one knows how long human beings can survive on this planet.Tidal flow speed is very big in some places, for example, at the ocean strait; some entrances of semi-enclosed sea bays. It involves large energy,we can calculate it.According to Newton second law theory ΣF=ma, we can get the momentum theorem ΣFdt=mdv. According to dv, we can calculate the tidal flow force ΣF, then we can calculate how much energy we can get.Tide comes and goes every day; we can use tidal flow to generate electric power. We should reduce coal power stations to cut down pollution to prevent global warming, it is a good reason to start tidal power stations.We can build a device like Fig(1) in the following, the impeller has 8 square vanes and the shaft is on the surface of sea water. The first calculation,the square vane area is 1(m²).When the tidal flow speed is 1(m/s), presuming the impeller speed is 5(rpm),we can get the power of this device 235.6(W) . When enlarging both length and width into 2 meters,if the tidal flow speed is 2(m/s) and the impeller speed is 5(rpm),we get the power of this device nearly 15.1(KW) .Although it is little energy, we make sure we can get green energy from the ocean; we can make it bigger to get more power. We should do it, to prevent global warming.We must try our best to preserve our earth,otherwise， human beings will die out.
Multi-step two-copy distillation of squeezed states via two photon subtraction
Authors: Grebien Stephan , Göttsch Julian , Hage Boris , Fiurasek Jaromir , Schnabel Roman 
Published: April 2022

Abstract
Squeezed states of light have been improving the sensitivity of gravitational-wave observatories and are nonclassical resources of quantum cryptography and envisioned photonic quantum computers. The higher the squeeze factor is, the higher is the quantum advantage. Almost all applications of squeezed light require multi-path optical interference, whose unavoidable imperfections introduce optical loss, degrade the squeeze factor, as well as the quantum advantage.
Here, for the first time, we experimentally demonstrate the distillation of Gaussian squeezed states that suffered from Gaussian photon loss. Our demonstration already involves two distillation steps. The first step improved the squeeze factor from 2.4 dB to 2.8 dB by the subtraction of two photons. The second step improved the value from 2.8 dB to 3.4 dB by a Gaussification protocol. It was realised on data measured at different times via an 8-port balanced homodyne detector and via data post-processing. The number of distillation steps can be increased by longer data sampling times, without additional hardware. We propose and discuss the application to quantum cryptography and photonic quantum computers.
Prognostic value of CYBB as potential biomarkers for lung adenocarcinoma by TCGA and clinical validation
Authors: Liu Yingjie , Han Di , Zheng Yuan hang , lin Yi , Yang Chunqing , Yang Lun 
Published: April 2022

Abstract
Lung adenocarcinoma (LUAD) causes high morbidity and mortality; therefore, early diagnosis is essential. In recent years, rapid increases in high-throughput sequencing technologies’ efficiency and the continuous improvement of comprehensive online databases have facilitated the study of the genomic changes that affect tumor progression and the identification of tumor biomarkers; Therefore, we hope to find out the genes that may affect the progression and prognosis of LUAD. In this study, we used CIBERSORT and Estimate computing methods to analyzed data from The Cancer Genome Atlas, including the analysis of the proportion of tumor-infiltrating immune cells (TIC) in the tumor microenvironment (TME), cox regression analysis of differentially expressed genes, and cross analysis of protein interaction networks (PPI). We found that Cytochrome b-245 beta chain (CYBB), an indispensable gene in the immune system, also plays a vital role in lung cancer pathogenesis. Meanwhile, Western blotting, qRT-PCR and IHC were used to verify the down-regulation of CYBB expression in LUAD patients. Reduced CYBB expression occurs in patients with lung cancer, indicating that it may be a valuable biomarker and facilitate early diagnosis.
A Critical Analysis of the Higher Education Relevance and Quality Agency’s (HERQA) for Institutional Quality Audit Tools: Focus Areas, Thresholds, References, and Checklist of the University’s of Gondar
Authors: Tedla Tadesse Abera ,   2.	Yilfashewa Seyoum Mekuria
Published: April 2022

Abstract

This study was targeted to investigate the nature of quality auditing guidelines in-side-out, unlike previous studies which reported situational analysis on quality education about Ethiopian Higher Education Institutions (HEIs). The first two documents were HERQA’s areas of focus for institutional quality audits and institutional quality auditing guidance on focus area thresholds. And the third document was institutional quality audit checklist which was developed by the University of Gondar. The third document was not considered to be reviewed at the outset and yet, considered after the review of the two documents of HERQA’s concluded and visible gap was witnessed. Qualitative Document Analysis with specific READ approach was employed in analyzing the three documents: (1) ready your materials, (2) extract data, (3) analyze data, and (4) distil your findings. Results indicated the three documents were largely unrealistic to the existing situation of HEIs of the country, with conclusion that Ethiopia’s HERQA and HEIs’ endeavor on developing, improving, and utilizing a quality audit checklist guideline is an unfinished job, and was recommended exerted efforts should be continued.
Evaluation of marsupialization for radicular cysts in children
Authors: Zhang Junwei , Zhao Tianyu , Piao Zhengguo , Ouyang Kexiong 
Published: April 2022

Abstract
PurposeThis study aimed to investigate the clinical diagnosis and effect of marsupialization for radicular cysts in children. MethodsA retrospective analysis of a 3-year database was performed to evaluate both clinical and radiological features of 26 children with radicular cysts of the jaws. ResultsPediatric jaw cysts are rarely symptomatic and often difficult to differentiate on the basis of clinical presentation and radiologic features alone. When some of these patients first came to the pediatric dentistry department or orthodontics department because of jaw swelling or unerupted teeth, and a decayed tooth could sometimes be found on the lesion. The results of pathological examinations after marsupialization revealed radicular cysts in all cases. The postoperative follow-up period was 12-27 months. All 26 children showed good results with permanent teeth eruption, and seven patients required orthodontic treatment. Conclusions The diagnosis of radicular cysts of the jaws in children depends on correct interpretation of clinical, radiographic, and pathological data. Marsupialization can have a good therapeutic effect with a low risk of surgical complications, and can protect vital anatomical structures such as the roots of the teeth, inferior alveolar nerve, maxillary sinus, and permanent tooth germs.
High efficiency and broadband wide-angle linear polarization converter based on dumbbell-like resonant structure
Authors: Wang Ze , Tian Jinping , Yang Rongcao 
Published: April 2022

Abstract
In this paper, a broadband wide-angle reflective linear polarization converter is designed, of which a dumbbell-like resonant structure is applied to form the unit cell of the periodic metasurface. Research results show that characteristics of broadband polarization conversion with higher PCR in the range of 13.3 GHz to 24.1 GHz comes from the multiple electric and magnetic resonances along the dumbbell-like resonant unit. Meanwhile, the entire conversion performance can be well controlled through changing the structural parameters. In addition, the property of wide-angle polarization conversion can make it convenient for the real application. Due to the simple structure together with the excellent performance of the proposed linear polarization converter, it has promising values in polarization converting, detecting, imaging and so on in the GHz frequency range.