bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mobile shopping beauty live commerce changes in COVID‐19 pandemic focused on fun contents of MZ generation in Republic of Korea
Authors: Lee Jinkyung , Kwon Ki Han 
Published: April 2022

AbstractBackgroundSevere acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) is the new virus responsible for the coronavirus disease 2019 (COVID‐19) pandemic. According to these circumstances, a study was conducted to prepare a long‐term non‐face‐to‐face outpatient treatment service during the COVID‐19 pandemic. Given the current situation of the times, it is expected that there will be no return to the non‐face‐to‐face prior.ObjectivesTherefore, this study descriptively investigated changes in consumer demand for new changes in the cosmetic market that has changed since COVID‐19.MethodsIt was written with reference to keywords such as “Covid Mobile Shopping,” “Covid MZ Generation,” “Covid Live Commerce,” and “Fun Content.” This study was conducted by searches on PubMed, Google Scholar and Scopus, and ResearchGate. A total of 398 papers were found, of which 40 were successfully included in this study.ResultsIt is expected that this era will be centered on the MZ generation, which has emerged as a new consumer in the market, where individual tastes and individuality are emphasized. Millennials and Generation Z, also called the “SNS generation,” are focusing on consumption trends.ConclusionIt is expected that this review will be used as important marketing material for a new change in the cosmetics market by clearly understanding the consumer needs of the cosmetics industry that has changed in the untact era.
Morphology and physiology in some small pelagic cetaceans: Is Dall's porpoise a deep diver and a thoroughbred of the sea?
Authors: Ponganis Paul J. , Fujise Yoshihiro , Miyazaki Nobuyuki 
Published: April 2022

AbstractHeart size and blood oxygen (O2) in Dall's porpoises (Phocoenoides dalli), Pacific white‐sided dolphins (Lagenorhynchus obliquidens), and common bottlenose dolphins (Tursiops truncatus) correlate with reported swim speeds and dive behavior. Deep‐dive capacity is often associated with smaller relative lung masses, larger “inexpensive” tissue masses (locomotor muscle + blubber + bone masses), and larger total O2 stores. To gain insight into dive behaviors and surface travel of small pelagic cetaceans, we compared body compositions of Dall's porpoises, Pacific white‐sided dolphins, and northern right whale dolphins (Lissodelphis borealis) to the bottlenose dolphin. Relative lung masses, inexpensive tissue masses, and total O2 stores of Dall's porpoises and Pacific white‐sided dolphins were consistent with deeper dive capacities than in the coastal bottlenose dolphin. In contrast to known low myoglobin concentrations in northern right whale dolphins, inexpensive tissue mass suggested intermediate dive capacity. The estimated body O2 store of Dall's porpoise was among the highest of any cetacean. The relatively large hearts of Dall's porpoises, Pacific white‐sided dolphins, and northern right whale dolphins are hypothesized as especially important during high‐speed surface travel. Based on similarities in locomotory performance, morphology, and physiology to those of the horse, we consider Dall's porpoise a thoroughbred of the sea.
Mechanism of METTL14 and m6A modification of lncRNA MALAT1 in the proliferation of oral squamous cell carcinoma cells
Authors: Li Jinli , Momen‐Heravi Fatemeh , Wu Xun , He Kaili 
Published: April 2022

AbstractObjectivesMethyltransferase‐like 14 (METTL14) plays an epigenetic role in various cancer through N6‐methyladenosine (m6A) modification. This study sought to analyze the mechanism of METTL14 in oral squamous cell carcinoma (OSCC) cell proliferation.MethodsExpression levels of METTL14, lncRNA metastasis associated with lung adenocarcinoma transcript 1 (lncRNA MALAT1), microRNA (miR)‐224‐5p, and histone lysine demethylase 2A (KDM2A) in OSCC tissues (N = 40), and cell lines (FaDu, SCC‐25, CAL‐27, and SCC‐15) were detected. Cell viability and colony formation capacity were assessed. m6A level, stability, and subcellular localization of lncRNA MALAT1 were determined. Nude mouse xenograft tumor assay was performed to confirm the role of METTL14 in vivo.ResultsMETTL14 and lncRNA MALAT1 were upregulated, and miR‐224‐5p was downregulated in OSCC tissues and cells. Silencing METTL14 repressed OSCC cell viability and colony formation. Overexpression of MALAT1 and KDM2A or miR‐224‐5p downregulation reversed the inhibition of silencing METTL14 on OSCC cell proliferation. METTL14 induced m6A modification of MALAT1 to upregulate MALAT1. MALAT1 is comparatively bound to miR‐224‐5p to promote KDM2A transcription. In vivo, METTL14 promoted tumor growth via regulating MALAT1/miR‐224‐5p/ KDM2A.ConclusionsOverall, our findings verified the therapeutic role of silencing METTL14 in OSCC treatment through the MALAT1/miR‐224‐5p/KDM2A axis.
Epstein–Barr virus‐associated risk factors for post‐transplant lymphoproliferative disease in pediatric liver transplant recipients
Authors: Quintero Bernabeu Jesus , Juamperez Javier , Mercadal‐Hally Maria , Larrarte King Mauricio , Gallego Melcon Soledad , Gros Subias Luis , Sábado Álvarez Constantino , Soler‐Palacin Pere , Melendo Pérez Susana , Esperalba Juliana , Navarro Jiménez Alexandra , Garrido Pontnou Marta , Camacho Soriano Jessica , Hidalgo Llompart Ernest , Bilbao Aguirre Itxarone , Charco Torra Ramón 
Published: April 2022

AbstractBackgroundPost‐transplant lymphoproliferative disorder (PTLD) are the most common de novo malignancies after liver transplantation (LT) in children. The aim of our study was to assess the role of pre‐LT EBV status and post‐LT EBV viral load as risk factors for developing PTLD in a cohort of pediatric LT recipients.MethodsData of all children who underwent LT between January 2002 and December 2019 were collected. Two cohorts were built EBV pre‐LT primary infected cohort and EBV post‐LT primary infected cohort. Moreover, using the maximal EBV viral load, a ROC curve was constructed to find a cutoff point for the diagnosis of PTLD.ResultsAmong the 251 patients included in the study, fifteen PTLD episodes in 14 LT recipients were detected (2 plasmacytic hyperplasia, 10 polymorphic PTLD, 2 monomorphic PTLD, and 1 Classical‐Hodgkin's lymphoma). Patients of the EBV post‐LT primary infected cohort were 17.1 times more likely to develop a PTLD than patients of the EBV pre‐LT primary infected cohort (2.2–133.5). The EBV viral load value to predict PTLD was set at 211 000 UI/mL (93.3% sensitivity and 77.1% specificity; AUC 93.8%; IC 0.89–0.98). In EBV post‐LT primary infected cohort, patients with a viral load above 211 000 were 30 times more likely to develop PTLD than patients with a viral load below this value (OR 29.8; 3.7–241.1; p < 0.001).ConclusionsThe combination of pretransplant EBV serological status with EBV post‐transplant viral load could be a powerful tool to stratify the risk of PTLD in pediatric LT patients.
Effects of tacrolimus intrapatient variability and CYP3A5 polymorphism on the outcomes of pediatric kidney transplantation
Authors: Choi Jin Sun , Ko Hyunmin , Kim Hyo Kee , Chung Chris , Han Ahram , Min Seung‐Kee , Ha Jongwon , Kang Hee Gyung , Ha Il Soo , Min Sangil 
Published: April 2022

AbstractBackgroundThe intrapatient variability (IPV) of tacrolimus (Tac) is associated with the long‐term outcome of kidney transplantation. The CYP3A single‐nucleotide polymorphism (SNP) may affect the IPV of Tac. We investigated the impact of IPV and genetic polymorphism in pediatric patients who received kidney transplantation.MethodsA total of 202 pediatric renal transplant recipients from 2000 to 2016 were analyzed retrospectively. The IPV was calculated between 6 and 12 months after surgery. Among these patients, CYP3A5 polymorphism was analyzed in 67 patients.ResultsThe group with high IPV had a significantly higher rate of de novo donor‐specific human leukocyte antigen antibodies (dnDSA) development (35.7% vs. 16.7%, p = .003). The high IPV group also had a higher incidence of T‐cell‐mediated rejection (TCMR; p < .001). The high IPV had no significant influence on Epstein–Barr virus, cytomegalovirus, and BK virus viremia but was associated with the incidence of posttransplant lymphoproliferative disorders (p = .003). Overall, the graft survival rate was inferior in the high IPV group (p < .001). The CYP3A5 SNPs did not significantly affect the IPV of Tac. In the CYP3A5 expressor group, however, the IPV was significantly associated with the TCMR‐free survival rate (p < .001).ConclusionThe IPV of Tac had a significant impact on dnDSA development, occurrence of acute TCMR, and graft failure in pediatric patients who received renal transplantation. CYP3A5 expressors with high IPV of Tac showed worse outcomes, while the CYP3A5 polymorphism had no impact on IPV of Tac.
Synergistic effects of myo‐inositol and melatonin on cryopreservation of goat spermatozoa
Authors: Tanhaei Vash Nima , Nadri Parisa , Karimi Akbar 
Published: April 2022

AbstractOverproduction of reactive oxygen species (ROS) during sperm cryopreservation has a detrimental effect on sperm parameters. Therefore, the use of antioxidants in the sperm freezing extender can reduce ROS destructive effects. In this study, we investigated whether co‐supplementation of melatonin and myo‐inositol into the semen extender can improve the post‐cryopreservation quality of goat spermatozoa. After the freeze–thawing process, sperm motility, viability, plasma membrane and acrosome intact morphology were improved in the combined myo‐inositol and melatonin group compared to both individual and the control groups (p < .05). In addition, the mean of sperm ROS, DNA damage and lipid peroxidation were reduced in co‐supplementation of myo‐inositol and melatonin compared to their individual counterparts (p < .05). Therefore, the synergistic effects of myo‐inositol and melatonin on the cryopreserved spermatozoa are highly likely mediated through the reduction in important factors involved in the sperm lipid peroxidation. Finally, we used the cryopreserved spermatozoa for in vitro production of embryos. Results showed that combined group of myo‐inositol and melatonin improved the cleavage rate compared to both individual and control groups, although blastocyst rate was improved using both individual and combined groups. In conclusion, co‐supplementation of melatonin and myo‐inositol is a promising approach for the improvement of goat sperm cryopreservation.
ABI3‐ and PIF1‐mediated regulation of GIG1 enhances seed germination by detoxification of methylglyoxal in Arabidopsis
Authors: Kim Dong‐Hwan , Lee Sang Woo , Moon Heewon , Choi Dasom , Kim Sujeong , Kang Hajeong , Kim Jungtae , Choi Giltsu , Huq Enamul 
Published: April 2022

SUMMARYMethylglyoxal (MG) is a toxic by‐product of the glycolysis pathway in most living organisms and was previously shown to inhibit seed germination. MG is detoxified by glyoxalase I and II family proteins in plants. MG is abundantly produced during early embryogenesis in Arabidopsis seeds. However, the mechanism that alleviates the toxic effect of MG in maturing seeds is poorly understood. In this study, by T‐DNA mutant population screening, we found that mutations in a glyoxalase I gene (named GERMINATION‐IMPAIRED GLYOXALASE 1, GIG1) led to significantly impaired germination compared with wild‐type seeds. Transformation of full‐length GIG1 cDNA under the constitutively active cauliflower mosaic virus 35S promoter in the gig1 background completely recovered the seed germination phenotype. Quantitative reverse transcription polymerase chain reaction (qRT‐PCR) analyses revealed that GIG1 is uniquely expressed in seeds and is upregulated by abscisic acid (ABA) and downregulated by gibberellic acid (GA) during seed germination. An ABA signaling component, ABI3, directly activated GIG1 in maturing seeds. In addition, PHYTOCHROME INTERACTING FACTOR 1 (PIF1) also plays cooperatively with ABI3 in the regulation of GIG1 expression in the early stage of imbibed seeds. Furthermore, GIG1 expression is stably silenced by epigenetic repressors such as polycomb repressor complexes. Altogether, our results indicate that light and ABA signaling cooperate to enhance seed germination by the upregulation of GIG1 to detoxify MG in maturing seeds.
Duodenal leiomyosarcoma in a cat: Cytologic, pathologic, and immunohistochemical findings
Authors: Henker Luan C. , Dal Pont Tainah P. , dos Santos Igor R. , Bandinelli Marcele B. , Zardo Izadora L. , Rodrigues Rochana , Pavarini Saulo P. 
Published: April 2022

AbstractA 7‐year‐old mixed‐breed neutered male cat was presented with a history of chronic vomiting with increased frequency in the last month, progressing to depression and profuse projectile vomiting. Abdominal ultrasonography revealed an area of marked segmental duodenal thickening associated with a nodule, and euthanasia was performed due to a poor prognosis. Grossly, at the postmortem examination, the wall of a duodenal segment was severely expanded by a nodule measuring 5.0 cm in diameter, resulting in marked luminal narrowing and obstruction. Smears were made by scraping the cut surface of the tumor during the postmortem examination. The smears were highly cellular and contained mesenchymal cells arranged individually or in large non‐cohesive aggregates. Cells varied in morphology from spindle to round to stellate‐shaped with marked anisocytosis and anisokaryosis. Numerous bi‐ and multinucleated neoplastic cells were observed. Histologic examination revealed a densely cellular neoplastic proliferation of mesenchymal cells that effaced the duodenal submucosa, muscularis externa, and serosa layers. Most cells were spindle‐shaped; however, some tumor areas had numerous round cells and bi‐ and multinucleated neoplastic cells. Spindle cells showed variable cytoplasmic immunoreactivity for vimentin, smooth muscle actin, and desmin. Round, bi‐, and multinucleated giant cells only had marked multifocal cytoplasmic immunoreactivity for vimentin. Neoplastic cells did not have immunoreactivity for cytokeratin, GFAP, S100, and CD117. A final diagnosis of duodenal leiomyosarcoma was made. This article reports the pathologic, cytologic, and immunohistochemical findings of this case and discusses the main differential diagnoses in cases of intestinal sarcomas in domestic animals.
Experimental Investigation on Leakage Characteristics of Low-Hysteresis Brush Seals
Authors: Li Pengfei , Hu Yaping , Ji Honghu , Cui Xuechao , Liu Lei , Li Shiming 
Published: April 2022

Abstract
Brush seals are widely used in industry because of their excellent contact and flexible sealing. This paper investigates the influence of the axial width of the pressure relief chamber and the bristle diameter on the leakage characteristics of brush seals. Rotor speed cycle tests are conducted using low-hysteresis brush seals, and the rotor's centrifugal expansion and recovery process is simulated by increasing and decreasing the rotor diameter in the static state. The results show that the low-hysteresis structure has better sealing performance than the conventional brush seal, and the optimal axial width of the pressure relief chamber is 0.4 mm. This structure gives the smallest leakage amount. The leakage coefficient of the low-hysteresis structure with a bristle diameter of 0.13 mm is about 37% higher than that with a bristle diameter of 0.08 mm over the entire test speed range and exhibits stronger hysteresis effects. The results of this paper can be used as a reference for the design of brush seals for engineering applications.
Null geodesics and shadow of 4D Einstein–Gauss–Bonnet black holes surrounded by quintessence
Authors: Heydari-Fard Malihe , Heydari-Fard Mohaddese 
Published: April 2022

We study the properties of the null geodesics of four-dimensional Einstein–Gauss–Bonnet (4D EGB) black holes surrounded by quintessence matter, recently derived by Shah et al. [Phys. Lett. B 818 (2021) 136383]. Due to the quintessence correction, we discuss the radial and nonradial geodesics. For the case of nonradial geodesics we obtain the effective potential, photon sphere and impact parameter associated to the null geodesics in detail. We analyze the different possible orbits of massless particles (i.e. photons) such as unstable circular orbits and unbounded orbits and investigate the role of the Gauss–Bonnet coupling [Formula: see text] and the quintessence parameter q on the null geodesic trajectories. Moreover, we study the effects of the model parameters on the shadow cast by such black holes. The results are compared to that of Schwarzschild black hole with and without quintessence matter and 4D EGB black holes without quintessence. As a physical application of null geodesics, the deflection angle is calculated and the effect of the quintessence matter on it is investigated.
Confined chiral dynamo action in torsional dilatonic DWs from CME discontinuities
Authors: Garcia de Andrade L. C. 
Published: April 2022

In this paper, spin polarized domain walls in Einstein–Cartan (EC) gravity have been recently investigated [L. C. Garcia de Andrade, Einstein–Cartan non-supersymmetric dynamo walls, Ann. Phys. 432 (2021).], where the spin polarizes along the direction orthogonal to planar domain wall. In this case, dynamo effects may appear on the wall. Moreover, dilatonic domain walls (DDWs) have shown to be responsible for inflating DWs in EC gravity, where DWs were non-magnetized [L. Garcia de Andrade, Axial and chiral anomalies in Riemann–Cartan spacetime black holes and electrodynamics, Class. Quantum Grav. 16 (1999) 2097–2103.]. In this paper, our goal is to show that when we consider a magnetized DW in the EC–Maxwell cosmology, the dilaton potential in the form of a DDW potential expressed in terms of torsion and the magnetic energy density may drive dynamo effects. Analytical solution of the dynamo equation shows that depending on the handness of DDW metric, the magnetic fields are amplified by dynamo action. From the coupled system of ECM and dilaton field equations, we find a relation between the magnetic energy density of [Formula: see text] and the DDW torsion of [Formula: see text] which leads to a thin DDW thickness of [Formula: see text]. For a galactic magnetic field, energy density of [Formula: see text] leads to a thickness of [Formula: see text], a much thinner DDW. For galactic dynamo amplification, the ratio r between the magnetic energy density and photon energy density is around [Formula: see text]. From this ratio, a relation between photon mass density and torsion is obtained. Chiral Magnetic effect (CME), torsion and magnetic discontinuities along the wall are investigated. Magnetic field discontinuity across the wall allows us to understand why the magnetic fields at DDW must be located along the wall since the orthogonal magnetic field may vanish.
Modern tech can't shield your secret identity
Authors: Hong Jason 
Published: April 2022

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Jason Hong considers how modern computing technologies would undermine superheroes' anonymity.
Language & Coding Creativity
Authors: Murati Ermira 
Published: April 2022

Abstract
Machines are gaining understanding of language at a very rapid pace. This achievement has given rise to a host of creative and business applications using natural language processing (NLP) engines, such as OpenAIs GPT-3. NLP applications do not simply change commerce and literature. They raise new questions about how human beings relate to machines and how that symbiosis of communication will evolve as the future rushes toward us.
Automation, Augmentation, Value Creation & the Distribution of Income
& Wealth
Authors: Spence Michael 
Published: April 2022

Abstract
Digital technologies are transforming the economy and society. The dimensionality and scope of the impacts are bewildering and too numerous to cover in a single essay. But of all the concerns around digital technology (and there are many), perhaps none has attracted more attention, and generated deeper anxiety, than the impact of various types of automation on work and on the structure of the economy. I focus on the ways in which the digitization of virtually all data, information, and content is transforming economies. And more specifically, I look at the impacts of automation, augmentation, AI, machine learning, and advanced robotics on economic transformations, on work, and on the distribution of income and wealth.
The Moral Dimension of AI-Assisted Decision-Making: Some Practical
Perspectives from the Front Lines
Authors: Carter Ash 
Published: April 2022

Abstract
This essay takes an engineering approach to ensuring that the deployment of artificial intelligence does not confound ethical principles, even in sensitive applications like national security. There are design techniques in all three parts of the AI architecture-algorithms, data sets, and applications-that can be used to incorporate important moral considerations. The newness and complexity of AI cannot therefore serve as an excuse for immoral outcomes of deployment by companies or governments.
What to Do If N Is Two?
Authors: Fries Pascal , Maris Eric 
Published: April 2022

Abstract
The field of in vivo neurophysiology currently uses statistical standards that are based on tradition rather than formal analysis. Typically, data from two (or few) animals are pooled for one statistical test, or a significant test in a first animal is replicated in one (or few) further animals. The use of more than one animal is widely believed to allow an inference on the population. Here, we explain that a useful inference on the population would require larger numbers and a different statistical approach. The field should consider to perform studies at that standard, potentially through coordinated multicenter efforts, for selected questions of exceptional importance. Yet, for many questions, this is ethically and/or economically not justifiable. We explain why in those studies with two (or few) animals, any useful inference is limited to the sample of investigated animals, irrespective of whether it is based on few animals, two animals, or a single animal.
Prevalence, Predictors, and Impact of Coronary Artery Ectasia in Patients With Atherosclerotic Heart Disease
Authors: Xi Ziwei , Qiu Hong , Guo Tingting , Wang Yong , Dou Kefei , Xu Bo , Wu Yongjian , Qiao Shubin , Yang Weixian , Yang Yuejin , Gao Runlin 
Published: April 2022

The clinical relevance of coronary artery ectasia (CAE) is poorly understood. We investigated the prevalence, potential predictors, and prognostic significance of CAE in patients with atherosclerotic coronary artery disease. Consecutive patients undergoing percutaneous coronary intervention (PCI) from January 2016 to December 2018 were included and followed up for 1 year. CAE was diagnosed as an abnormal dilation >1.5-fold the diameter of adjacent normal segments on angiography. A total of 590 patients with CAE were identified from 36 790 patients undergoing PCI (overall rate of CAE: 1.6%). In multivariate analysis, variables including body mass index >30 kg/m2 (risk ratio, RR: 2.413, P = .018), ever-smoking (RR: 1.669, P < .001), hypertension (RR: 1.221, P = .025), acute myocardial infarction at admission (RR: 1.343, P = .004), no diabetes (RR: .810, P = .023), previous myocardial infarction (RR: 1.545, P < .001), no left main disease (RR: .632, P = .008) and multiple-vessel disease (RR: 1.326, P = .001), increased C-reactive protein (RR: 1.006, P = .012) were predictors of CAE. The incidence of adverse cardiovascular outcomes did not differ significantly between patients with or without CAE ( P = .203). CAE is not uncommon among patients undergoing PCI in this cohort study. The presence of CAE vs its absence had no significant impact on 1-year clinical outcomes after PCI.