bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exercise Alleviates the Apolipoprotein A5-Toll-Like Receptor 4 Axis Impairment in Mice With High-Fat Diet-Induced Non-alcoholic Steatohepatitis
Authors: Yu Yang , Yu Lina , Cheng Nuo , Liu Xiaoguang , Fang Chunlu , Liu Shujing , Zhu Lin 
Published: December 2021

Background: Apolipoprotein A5 (ApoA5), an important modulator of plasma and hepatic triglyceride metabolism, has been found to be downregulated by metformin to improve non-alcoholic fatty liver disease. Meanwhile, exercise has been recommended as a therapeutic strategy for non-alcoholic steatohepatitis (NASH). However, no study has yet determined whether exercise affects hepatic ApoA5 expression or the inhibition of ApoA5 to toll-like receptor 4 (TLR4). We herein examined the effects of exercise on hepatic ApoA5 expression and the relevance of ApoA5 and TLR4-mediated pathway in mice with high-fat diet (HFD)-induced NASH.Methods: Male C57BL/6J mice were built NASH model with high-fat diet for 12 weeks, and following mice were subjected to exercise for 12 weeks on a treadmill. Microscopy and enzyme-linked immunosorbent assay were used to measure histological analysis of liver and hepatic lipids, respectively. Quantitative real-time PCR and western blot were used to determined mRNA and protein levels of ApoA5 and TLR4-mediated nuclear factor kappa B (NF-κB) pathway components, respectively. ApoA5 overexpression plasmids transfected into mice to investigate the relevance of ApoA5 and TLR4.Results: 12 weeks of exercise remarkably alleviated HFD-induced hepatic lipid accumulation, inflammation, and fibrosis, as well as reduced serum lipopolysaccharide (LPS), hepatic TLR4, myeloid differentiation factor 88 (MyD88), and NF-κBp65 expression. Importantly, exercise did not reduce ApoA5 expression but instead enhanced its ability to suppress TLR4-mediated NF-κB pathway components by decreasing circulating LPS in our experiments involving transfection of ApoA5 overexpression plasmids and LPS interventions.Conclusion: The results demonstrated that exercise improved HFD-induced NASH by triggering the inhibitory effects of ApoA5 on the TLR4-mediated NF-κB pathway.
Parental Chronic Illness, Internalizing Problems in Young Adulthood and the Mediating Role of Adolescent Attachment to Parents: A Prospective Cohort Study
Authors: Kaasbøll Jannike , Skokauskas Norbert , Lydersen Stian , Sund Anne Mari 
Published: December 2021

Background: Parental chronic illness is associated with an elevated risk for developing social-emotional and behavioral problems in children, in particular internalizing symptoms. This study aimed to investigate the associations between parental chronic illness when participants were adolescents and subsequent internalizing symptoms in young adulthood and whether adolescent attachment to parents or peers mediates these associations.Methods: The study used longitudinal survey data from the Youth and Mental Health Study, a cohort study including a representative sample of youth in central Norway assessed in the period from 1999 to 2000 (mean age 14.9 years) and in 2012 (mean age 27.2 years) (N = 1,266). The data consist of youth self-reports at both time points. Parental chronic illness was reported by the adolescents, quality of attachment was measured using the Inventory of Parent and Peer Attachment (IPPA), and internalizing problems were assessed in young adulthood by using the Adult Self-Report (ASR). Data were analyzed using parallel mediation analyses, controlling for adolescent sex, parental socioeconomic status, and divorce. In addition, separate analyses were conducted for adolescent girls and boys.Results: The total longitudinal effect was significant for both maternal and paternal chronic illness on internalizing problems in young adulthood. The direct effect on internalizing problems was only significant for maternal chronic illness. Attachment to fathers partially mediated the relationship between maternal chronic illness in adolescence and internalizing symptoms in young adulthood, whereas attachment to both mothers and fathers fully mediated the relationship between paternal chronic illness in adolescence and internalizing symptoms in young adulthood. A separate analysis for girls and boys indicated that the results were only significant for girls. Parental chronic illness did not play a significant indirect effect via attachment to peers on internalizing problems.Conclusions: Identifying protective factors in the pathways between parental chronic illness and mental distress in children could guide measures that promote the well-being of the child and family. The study demonstrates the importance of targeting the entire family in chronic illness care.
INNOVATIVE APPROACHES IN THE WORK OF THE POLTAVA REGIONAL ENVIRONMENTAL AND NATURALISTIC CENTER FOR STUDENT YOUTH
Authors: BRIDZHAK L. 
Published: December 2021

In the article, the author raises the problem of finding optimal forms and methods of working with pupils of an institution of extracurricular education in order to form a socially mature person who will be successful in the future.On the example of the work of the educational center of the ecocentre, one of the most important areas of the work of the institution of out-of-school education is re-structured: the restructuring of the content and quality of education, the application of the achievements of science and practice of the combination of traditional and non-traditional forms of work. Exposes the essence of pedagogical innovations, which are implemented in the institution.The author argues that changing the content of education, changing the approach to the pedagogical process leads to changes in the implementation of the model of modern pedagogical activity, the creation of an educational environment adapted to the needs of the child's personality development, her psychological, intellectual, creative abilities, the formation of social experience based on her own desires , natural inclinations and deposits.
PEDAGOGICAL CONDITIONS OF FORMATION OF LEADERSHIP QUALITIES AT STUDENTS OF ECONOMIC UNIVERSITIES
Authors: KARMANENKO V. 
Published: December 2021

The article analyzes the interpretation of the terms "conditions" and "pedagogical conditions". The significance and conceptual provisions of pedagogical conditions for the formation of leadership qualities in students of economic universities are determined.A system of pedagogical conditions for the formation of leadership qualities among students of economic universities is singled out. The first pedagogical condition for the formation of leadership qualities among students of economic universities is the creation of an open educational environment for an economic university, which allows building an individual educational trajectory for each student and taking into account the specifics of the professional activity of a future specialist. The second pedagogical condition for the formation of leadership qualities among students of economic universities is the creation of a developing personality-oriented environment in the educational and extra-curricular interaction of students. Its technological arsenal includes methods and techniques that meet such requirements as: dialogicity; activity-creative character; orientation in support of individual development of the individual; providing the student with the necessary space, freedom to make independent decisions, creativity, choice of content and ways of doing things.The emphasis is on the development of a leadership paradigm through the organization of training work. The third pedagogical condition for the formation of leadership skills among students of economic universities is the introduction of a leadership paradigm through the organization of interactive forms of work (trainings) at the School of the Leader. It is described that the program of modular discipline "Fundamentals of Leadership" has been developed. "Personal and professional efficiency. A series of trainings on leadership development for students of economic universities "contains interactive group and individual tasks for obtaining, developing and improving personal leadership qualities. The purpose, tasks and principles of the implementation of a complex of trainings on the development of leadership qualities in the students of economic universities have been determined. Trainings on development of leadership qualities at students of economic universities "Personal and professional efficiency" are distributed by modules. The content, types and direction of training exercises of each module are described.It is emphasized that taking these principles into account allows each student to feel unique personality, to acquire the necessary leadership skills that will help him in communicating, co-operating, and self-development.
THE CONCEPT OF LEADERSHIP COMPETENCE OF A MODERN MANAGER
Authors: NESTULIA S. 
Published: December 2021

The article describes the concept of the leader's competence of the modern manager as an integrated personality quality, which consists of the following structural components: cognitive (knowledge), operational-activity (ability and ability) and personality (personality traits, general and specific features of the leader). Leadership competence serves as the basis for the successful work of the modern manager in the team, because it consists not only in the qualitative performance of his official duties, but also in the peculiarities of his personal qualities. Therefore, the dominant component is the personal component.
REALISING AN INNOVATIVE APPROACH IN PROFESSIONALLY-ORIENTED ECONOMICS TEACHER TRAINING OF MASTER STUDENTS
Authors: ROMANIUK O. 
Published: December 2021

In the article the author discusses an innovative approach to training prospective teachers, analyses issues of realizing this approach in professionally-oriented training of master students for teaching economic disciplines and their pedagogical mastery development at economic universities as well as scientific and pedagogical aspects of the problem of modernizing the master student education system at the current stage of its development, summarises ways of using modern methods, technologies and innovative pedagogical ideas to modernize the master student professional training for teaching activity, focuses attention on factors influencing effectiveness of economics teacher professional training and its intensification, emphasizes the importance of economics master students for pedagogical activity at higher educational establishments and their pedagogical mastery development. The author states that modern education is characterized by innovative processes and teachers are real participants in these processes. The author points out that the process of globalization, development of the Internet, free access to educational information resources have brought about a unique opportunity to find solutions to problems connected with modernization and intensification of professionally-oriented training of prospective teachers, which means, in particular, an opportunity to use electronic resources for learning, to effectively combine different forms of education in order to improve pedagogical interaction between teacher and student. Therefore great attention must be paid to high quality teacher training and pedagogical mastery development. The author makes a conclusion that the analysed innovative approach is worth using in teacher training at economic universities in particular.
THEORY AND PRACTICE OF FORMING THE EXPERIENCE OF COMMUNICATIVE ACTIVITY OF FUTURE TEACHERS OF A FOREIGN LANGUAGE
Authors: TRUBACHOVA D. 
Published: December 2021

In the article the results of analysis of theoretical literature and pedagogical practice of problem of formation communicative activities of students of higher educational institutions have been compiled. The terms “communicative activities”, “communication” have been analyzed. The term of readiness to master communicative activities has been determined as a system of such properties and qualities of personality, which determine its mood for future communicative activities, communication, the ability to implement them. Criteria for the readiness of future teachers of a foreign language to master the communicative activity have been determined.The main structural components of communicative activities are the subject of communication is another person, partner in communication as a subject; partner in communication as a subject; the need for communication - the desire of man to know and evaluate other people, desire for self-knowledge; communicative motives are those for which communication is carried out, actions of communication - units of communicative activity, the task of communication is a goal whose achievement in a concrete communicative situation is directed to the various actions performed in the process of communication, the product of communication - the formation of material and spiritual nature, his result. The term “ways of communicative activities” has been found to characterize the learning process of future foreign language teachers has been developed. The structure of the method of communicative activity, which reflects the main components of communicative activity, has been presented. The way of communicative activity is aimed at solving a communicative problem. Stages of solving the communicative problem are analysis of the created communicative situation, definition of the communicative goal and objectives of the activity, review options for its achievement, the choice of the optimal, implementation of communication, analysis of the course of activity and the results. Taking into account these stages, types of ways of communicative activity have been defined. Criteria of formation of communicative activity have been developed: personality activity in communication; awareness of the principles of communicative activity, mechanisms of communication; possession of communication technique; awareness of communicative actions, the course of communicative activity in general, determined levels of their formation (creative, productive, sufficient).
METHODS OF CREATIVE DEVELOPMENT OF PRIMARY SCHOOL PUPILS DURING LESSONS OF MUSIC
Authors: LOBACH O. 
Published: December 2021

The article substantiates the classification of methods of creative development of primary school pupils during lessons of music.The methods are classified on the basis of the analysis of theoretical and methodological literature on a scientific problem (L. Horiunova, V. Hryhorieva, O. Lobova, L. Masol, H. Padalka, V. Rahozina, etc.), the results of experimental master's studies performed under the author's supervision, as well as generalization of his own pedagogical experience as a teacher of music in secondary comprehensive schools. The groups of methods in the classification correspond to the types of activities mentioned in the Typical Educational Programs 2018 (Primary Education) composed by two teams of authors under the supervision of O. Savchenko and R. Shiyan in order to achieve the goals and objectives of the New Ukrainian School.Classification includes five groups of methods of creative personality development: 1) musical-creative (rhythmic, melodic, form-forming, performing and creative tasks); 2) perceptive-creative (methods of stimulating creative perception of music, emotionally-based and musical-communicative situations, methods of observing music); 3) interpretive-creative (methods of presenting the results of music perception, artistic and creative tasks, methods of thinking about music, associative methods); 4) communicative-creative (language improvisation, interactive, dialogic, and autocommunicative); 5) scientific and creative methods (problem, heuristic, inventive, research). The article gives accurate examples for each group of methods (for example, inventive methods of focal objects, and various variants of morphological analysis). The author advocates the idea that a creative teacher is able to make any children’s activity during the lessons of music creative one.
PROVIDING GENDER EQUALITY OF TEACHERS TO LESSONS OF LABOR EDUCATION: METHODOLOGICAL ASPECT
Authors: MAIEVSKA O. 
Published: December 2021

The article considers the technologies of ensuring gender equality in the lessons of labor education. It is established that the content of gender education of students is oriented on the development of value orientations, the acquisition of the content of gender education, as well as the practical application of the acquired knowledge and values in everyday life. Overcoming stereotyped thinking from a gender issue in the lessons of labor training in Ukrainian schools is clearly in line with the strategy for introducing gender equality and non-discrimination in the field of education. Due to insufficient coverage of the problem under study in scientific literature, there is no single clear concept of gender education and the upbringing of students at the lessons of labor education and technology in the Ukrainian high school. Educational institutions have a major role in the gender education of children. Positive steps of Ministry of Education and Science of Ukraine and The Institute for the Modernization of Education, carried out in relation to the updating of the curriculum, the examination of textbooks, aimed at overcoming the problem of gender inequality in the lessons of labor education. Teachers-practitioners, by overcoming the gender problem in the learning process, offer interesting technologies for the implementation of creative student’s workshops. Overcoming gender inequality in lessons will open up a wide range of types of work to children. Often, teachers have a problem with the lack of workshops for girls and boys, so they have to choose projects that are suitable for both sexes. During the survey, the following modules were proposed: matchmaking, gannut, kinussayga, string art, marquetry, applique, origami, paper modeling of clothing and architecture, paper plastics, weaving from newspaper tubes. Artistic modeling of small sculptural plastics of animate, floral, gastronomic, technological or anthropological character from polymer clay, plasticine, cold porcelain, salty dough may interest children of all ages and sexes. Making of relief gifts, body parts for creation of dolls, bouquets of flowers, volumetric abstract and thematic panels, magnets, which can then be painted with acrylic and varnish, will allow to show designer creativity of boys and girls not only in the classroom, but also in extra time. These techniques can be diversified, ranging from plane images to voluminous and vice versa, changing the texture and materials, combining technology.
DEMOGRAPHIC POLICY IN A SCHOOL COURSE OF GEOGRAPHY
Authors: FEDII O. 
Published: December 2021

The article is devoted to the problem of studying demographic facts and processes in school geography of Ukraine. The significant need for students to study this topic is linked with social, economic, political and ecological processes from their own and public points of view. Realizing the peculiarities of contemporary demographic policies in different regions of the world and Ukraine, students deepen knowledge about the population, determine its role in shaping the future of society. The article deals with concepts of the «demographic policy», characteristics of modern measures of demographic policy in different countries. The main attention is paid to the importance of forming students' attitude towards state measures in the conditions of the global demographic explosion and the Ukrainian demographic crisis. This research was carried out within the performance of the problem to form the demographic concepts in schoolchildren’s minds during the study of social-economic geography.
POSTMODERN POETICS OF M. ATWOOD’S NOVEL “PENELOPIADА”
Authors: LENSKA S. 
Published: December 2021

Margaret Atwood is one of the most famous modern English-language writers. She has won numerous literary awards, including the Booker Prize twice. Her novel “Penelopiada” (2005) did not attract the attention of researchers. Therefore, the purpose of this article is a detailed analysis of the main features of the poetics of the novel as a model of postmodern prose.
The source of inspiration for the writer were the ancient myths and heroic poems “Iliada” and “Odyssey” by Homer. In ancient texts, Penelope is a minor heroine. She was the wife of Odysseus, the King of Ithaca, who fought for ten years under the walls of Troy, and then travelled for another ten years. And all this time his wife has been waiting for him, so Penelope is a symbol of marital ﬁdelity and patience.
Canadian author Margaret Atwood rethinks this image. Without disturbing the plot of the ancient epic, she psychologically motivates the actions of Penelope, shows the image of a lonely strong woman who is trying to survive in a cruel male world. This text reﬂects the feminist views of the author.
The article focuses on aspects of intertextuality, allusions, and creative dialogue with prototexts. The ﬁgurative structure of the novel, the semantic overemphasis of the images of Odysseus, Penelope and Elena, who ﬂed to Troy, are analysed. The events of the Trojan War are considered from the point of view of a woman who was not directly aﬀected by the hostilities, but whose life changed radically. Genre-compositional features of the novel are revealed. The originality of the narrative in the novel is clariﬁed: the story is told on behalf of Penelope, which adds psychological credibility to the image. The article also notes the techniques of irony, parody, which represent the text as a model of postmodernism.
LYUDMYLA OVDIENKO: BIOGRAPHY, AUTOBIOGRAPHY
Authors: MELEZHKO V. 
Published: December 2021

The publication presents the biography and autobiographical motives of the lyrics of the Ukrainian writer Lyudmyla Ovdienko. The purpose of the article is to present a biography and analysis of the poetic heritage of a fellow artist in the autobiographical aspect. We came to the conclusion that Lyudmila Ovdienko’s lyrical cycle is not only a speciﬁc type of context, but also a special form of creativity, a type of integrity that diﬀers from the usual collection of poems and is a sequence of texts formed by the author.
We are convinced that motives-images are signiﬁcant for the poet’s autobiographical lyrics. Of the many motifs that sound in the poems, the most prominent is the autobiographical. The emergence of the genre of autobiographical motives in the creative work of L. Ovdienko is determined by a special type of thinking of the author, the national tradition. The leading place in the consideration of lyric poetry is given to the study of motives-images (motive-family, motive-village). These motives the most signiﬁcant for the autobiographical lyrics of our compatriot.
SPATIAL-TEMPORAL SEMANTICS OF PREPOSITIONAL EQUIVALENTS
Authors: KYSLA N. 
Published: December 2021

The article investigates the prepositional-temporal semantics of prepositional equivalents, determines the philosophical and linguistic interpretation of categories of time and space, distinguishes the lexical composition of those prepositional units that are carriers of locative and temporal semantics, establishes contextual conditions under which each of the that semantic nuance, it was found that the immediate environment (verb and dependent noun) signiﬁcantly aﬀect the content plan of the prepositional equivalent.
The aim of the article is to elucidate the peculiarities of the functioning of prepositional equivalents with locative and temporal semantics. It was established that the prepositional equivalents immediately after, immediately before, immediately after, from the depth, behind the shoulders, on the way from, on the way from… to, on the way to, in place, in the interval from… to, in the interval between, in the middle can to be representatives of both locative and temporal signiﬁcance. Their speciﬁc semantic nuance depends on the immediate context.