bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical experience for Porphyromonas gingivalis detection in the cerebrospinal ţuid of patients with inţammatory diseases of the central nervous system and periodontitis
Authors: Volinska Tamara , Bondarchuk Olga , Horbenko Viktoriya 
Published: October 2022

Background. Porphyromonas. gingivalis is one of the most aggressive periodontopathogens causing periodontitis. Present scientific evidence proves the possibility of the influence of P.gingivalis on the pathogenesis of inflammatory diseases of the central nervous system.
Objective. To verify frequency of P.gingivalis detection within the cerebrospinal fluid of patients affected by various types of CNS inflammatory diseases.
Material and Methods. Cerebrospinal fluid of 36 patients, aged 18 to 79 years, with various infectious diseases of the central nervous system was analyzed during two years of study. Real-time PCR technique was used for P.gingivalis detection.
Results: 13 patients out of 36 demonstrated the presence of P.gingivalis within cerebrospinal fluid. 4 of them were diagnosed with meningoencephalitis, 3 patients had fever of unknown origin, at that one of them had Parkinson's disease, 3 patients had acute disseminated unspecified demyelination, 1 had multiple sclerosis, 1 had unspecified cerebrovascular disease. 77% of the total number of patients in whom P.gingivalis was detected in the cerebrospinal fluid, also were diagnosed with periodontitis.
Conclusions: Based on the data obtained, it can be assumed that P.gingivalis plays a significant role in the pathogenesis of inflammatory diseases of the central nervous system. Sanitation of the oral cavity and timely treatment of periodontal diseases can significantly reduce the incidence of inflammatory diseases of the central nervous system.
New analysis and classiŢcation of Angle’s class II malocclusion varieties during the mixed dentition period
Authors: Dakhno Larysa , Ivanova Kateryna 
Published: October 2022

Introduction: It is well known that Angle's class II malocclusion is the most common of all occlusal pathology. The prevalence of this malocclusion among children remains at 35-43% and tends to increase. Class II malocclusion negatively affects not only the functions of chewing, swallowing, breathing and speech, but also life in general, especially for children and adolescents. An analysis of modern scientific papers shows that variability of class II malocclusion is insufficiently covered in published classifications.
Objectives: To develop a classification of Angle's class II malocclusion forms based on the determination of angular and linear cephalometric parameters for children aged 7 to 12 years old and to analyze of their prevalence in Ukraine.
Material and Methods: 138 lateral cephalometric radiographs of children aged 7 to 12 years old with Angle's class II malocclusion were selected. Cephalometric analysis by Perillo-ID method was performed on all 138 radiographs. 68 lateral cephalometric radiographs were selected for further study.
Results: Cephalometric analysis by Perillo-ID method on 68 lateral cephalograms in children aged 7-12 years old showed a wide range of variability forms of Angle's class II malocclusion. The results of 7 angular and 4 linear parameters allowed to create a classification of Angle's class II malocclusion forms and sizes, taking into consideration the position of the lower jaw in children during the mixed dentition period.
Conclusions: Authors modified Perillo's cephalometric analysis, which allowed to create a detailed classification of Angle's class II malocclusion forms for children during the mixed dentition period. The new classification will allow to clearly differentiate the etiology of malocclusion, to differentiate the true mandible underdevelopment from its retroposition or rotation.
El internet de las cosas en la producción agrícola de Manabí-Ecuador
Authors: Fernández Villacrés Gustavo Eduardo , Moreno García Franklin Ulbio , Guerrero Aguilar Lorena Fernanda , Molina Mora Diego Patricio 
Published: October 2022

El presente trabajo investigativo tuvo como finalidad analizar el nivel de uso de la tecnología informática y en especial la 4.0 como elemento de apoyo al proceso agrícola de la provincia de Manabí. Se partió de la problemática relacionada con el desconocimiento sobre estos nuevos elementos tecnológicos, se fundamentó teóricamente aspectos como: industria y tecnología 4.0, producción agrícola y automatización, se investigó entre Docentes de la facultad de Agronomía de la Escuela Superior Politécnica Agrícola de Manabí (ESPAM) y a pequeños productores agrícolas de la región. El enfoque fue cuantitativo, se lo realizó en base a encuestas y se aplicaron métodos investigativos como el analítico-sintético y el inductivo-deductivo. Los resultados indican claramente que se desconocen estos elementos tecnológicos y no se los usa como elementos de apoyo agrícola a nivel de granjas productivas, académicamente algo se conoce y quizás el elemento más conocido es el dron. Luego de la investigación se ha desarrollado un prototipo que simula el uso del internet de las cosas para el control ambiental agrícola que ayuda a tomar decisiones en base a esa información generada automáticamente. Finalmente se concluye que la nueva tecnología 4.0 que se nos aproxima, será muy útil en los nuevos procesos de producción agrícola.
A Review of the Therapeutic Potentials of Stem Cells, Fibroblast Growth Factors and T-cells in Regenerative Medicine
Authors: Okikiade Adedeji , Osharode Aromedonghene , Oloye-Afolayan Olayinka , Ogunesan Damisola , Adijat Oyewole , Chibuike K. Ubah , Browne Kevin 
Published: October 2022

The human body is a complex structure with the innate ability to protect, defend, repair, and heal after damage or disease. For decades, medicine has faced problems that need the evolution of standard treatments and finding a way to accelerate the regenerative capabilities of the body, which possibly would not just treat but also cure certain diseases that previously had no cure. The question researchers have pondered on is whether or not it was possible as humans to use the body's innate healing power to our advantage and clinically accelerate or modify it to upgrade the treatment of certain diseases. The answer they found was in Regenerative Medicine (RM).
Historically the term regenerative medicine was found for the first time in a paper published in 1992 by Leland Kaiser. He made a list of approaches that would impact the future of hospitals. However, it is widely believed to have been coined during a 1999 conference on Lake Como by William Haseltine in an attempt to describe a novel field of medicine that combined knowledge from subjects like cell transplant, biochemistry, nanotechnology, prosthetics biomechanics, tissue engineering, and stem cell biology.
Regenerative Medicine is a relatively new field of clinical applications and research that is focused on the development of therapies like tissue engineering and stem cell technologies to repair, regenerate or replace defective, aged, injured, diseased, or permanently damaged organs, tissues or cells in order to restore them to their normal function.
It is important to note that RM has rapidly become one of the top treatment options for acute and chronic injuries, congenital diseases, and a wide range of acute and chronic diseases. It is more than just a field of medicine involving basic replacement therapies or traditional transplantation; it applies approaches like gene therapy, reprogramming of cell types, stem cell transplantation, and the use of soluble molecules, tissue engineering, and lots more.
The review article focuses on the therapeutic effects of fibroblast growth factors (FGFs), adipose-derived stem cells (ADSCs), and regulatory T cells (Tregs), and the possible role they play in tissue regeneration. They are apparently useful in the treatment of myriads of diseases expectedly having no cure.
Factors Predicting the Mathematics Performance of Grade 8 Students in the New Normal
Authors: Tobias Cristian A. , Diego Crispina V. 
Published: October 2022

Mathematics performance has been recognized as vital in the curricula in most of the country not only for academic success but also for its efficient application in everyday life. The study aimed to determine a significant relationship between the student, teacher, environmental, and parent involvement factors and students’ mathematics performance in a Catholic university for the Academic Year 2020-2021. Also, it determined which factors predict the mathematics performance of students. Using descriptive-correlational research design, 123 Grade 8 students answered a researcher-made test questionnaire to assess students' level of mathematics performance; these were interpreted using the Department of Education’s scale of standard. Furthermore, a researcher-made survey questionnaire was used to examine the level of extent of the four factors influencing the students’ mathematics performance, the correlation between these factors and students’ mathematics performance, and predictors of students’ mathematics performance. The assembled information was dealt with measurably utilizing mean, standard deviation, Kruskal-Wallis, Pearson product-moment correlation, Spearman's rho, and multiple linear regression. Results revealed that students’ level of mathematics performance was fairly-satisfactory (M=79.77, SD=8.96). The extent of influence of the factors is moderate (M=3.28, SD=0.33). There is a significant correlation between the extent of influence of factors as a whole and Mathematics performance [r(121)=0.235, p=0.009]. The results of the regression indicated that the predictor explained 7.3% of the variance [F(1, 121)=9.540, p=0.002, R2=0.073)]. The individual predictors were further examined and indicated that the teacher factor [β=6.440, t=3.089, p=0.002] significantly predicts Mathematics performance. This study provides significant insights into the vital role teachers play in finding a lasting solution to the students' perennial poor performance issues in mathematics in this new normal.
Assessment of Factors on Assimilation of Climate Smart Agricultural Practices in the North Eastern Hill Region of India: A SWOT-AHP Analysis
Authors: Devi Mayanglambam Victoria , Singh Rajkumar Josmee 
Published: October 2022

Aims: To appraise the factors for smooth assimilation of Climate Smart Agriculture (CSA) practices in the North Eastern Hill Region (NEHR) of India.
Study Design: Exploratory Research Design was followed for the study.
Place and Duration of Study: The study was conducted in the three states Arunachal Pradesh, Manipur and Meghalaya representing the Tropical, Sub-Tropical and Temperate Agro-Climatic Zone respectively in the region. The study was conducted during 2020-21.
Methodology: A Total of twenty-six (26) Extension agents including the Scientist of Indian Council of Agricultural Research (ICAR) centres, faculty of Colleges under Central Agricultural University, Imphal, and Subject Matter Specialists (SMS) in the KVKs who are working for more than three years in Climate change were selected purposively for the study. The study employed Delphi technique. On the subsequent three (3) iterations only seventeen (17) subject matter experts/specialists, scientist and faculties had responded for the study. To identify the factors of assimilation, Strengths, Weaknesses, Opportunities, Threats- Analytic Hierarchy Process (SWOT- AHP) analysis was employed in the study.
Results: The study uncovered that ‘Crop and Livestock Diversification due to existence of different Agro-Climatic Zones’; ‘Overly long Return on Investment span of CSA technologies on Adaptation and mitigation of Climate Change Consequences’; ‘Successful Market-aligned supply chain infrastructure from farm to fork’; and ‘Food insecurity & unsustainable livelihood due to negative impact of Climate Change on agriculture & allied enterprises’ were the most important Strengths, Weaknesses, Opportunities and Threats, respectively determining the assimilation of CSA practices in the region. The judgement given by the extension agents were found acceptable with inconsistency ratio below 10%.
Conclusion: Reflecting the reliable judgement amongst the experts, it shows a helpful scope for modifying the CSA practices that are developed in the region and need to focus on the bottleneck that need to be tackle for successful dissemination of CSA practices in the region.
Accessibility to Integrated Community Case Management of Childhood Pneumonia Services among Caregivers in Kisii County, Kenya
Authors: Mwambi Dennis Oroo , Osero Justus O. S. , Mwanzo Isaac , Cheboi Solomon 
Published: October 2022

Pneumonia is the leading cause of childhood illness and mortality worldwide. The number of children under five with pneumonia in Kisii County, Kenya, was 10% compared to the national average of 9% despite the integrated Community Case Management (iCCM) roll out. In order to identify factors associated with caregivers' access to iCCM services, a study was conducted.
Materials and Methods: Qualitative and quantitative approaches were used in this descriptive cross-sectional study. Purposive sampling was utilized to choose 10 informants while multistage and random sampling was applied to select 330 caregivers. Thematic content analysis and discourse analysis techniques were used to analyse qualitative data, while Statistical Package for Social Science (SPSS) version 22 was used in quantitative data.
Results: Only 33.6% of caregivers accessed iCCM for childhood pneumonia services. In 49% of cases, CHVs was the first point of contact after onset of pneumonia symptoms, with only 31.2% seeking help within 24 hours. 96% of CHVs did not follow the recommended iCCM diagnostic protocols, and only 34.8% prescribed antibiotics. Age (0.011), religion (0.007), and marital status (0.024) were significantly associated with access to iCCM. Business persons were 2.97 times (OR 2.972; CI 1.232,7.167; P= 0.015) more likely to access iCCM than farmers. Caregivers who perceived pneumonia to be severe were 3.03 more likely to access ICCM (OR 3.039;CI 1.703,5.424; P< 0.001) than opposite peers. Respondents who didn't think pandemics affected access were 10% (OR 0.119; CI .058,0.246; P<.0.001) more likely to access iCCM.
Conclusion: Access to iCCM was low and Community health volunteers (CHVs) were not the first point of care for pneumonia in children. Evidence of poor performance by CHVs in the areas of diagnosis, treatment, and the administration of antibiotics suggests that iCCM needs more monitoring and oversight.
Trends of Drug Practices in Pakistani National Athletes for Amplification of Game / Sport Performance
Authors: Javed Saeed , Baloch Aurangzaib Manzoor , Naseer Abida , Hamdani Syed Muhammad Zeshan Haider , Kousar Tehmina , Khan Imran Ullah , Asghar Adnan , Javed Waheed , Shariff Abd Rahim Mohd 
Published: October 2022

Aims: The primary aim of the present research was to provide awareness about the latest trends of drug practices of national athletes of Pakistan for the improvement of their sport performance.
Methodology: The samples were national athletes belonging to various sports departments of national level. The athletes were selected using snowball and convenient sampling approaches. The questionnaire employed for the data collection was self-administered. With the optimistic consent of the athletes, 80 questionnaires were dispatched at their home addresses. Therefore, 62 athletes (77.5%) returned the filled questionnaires. The requisite information of all filled questionnaires was coded in SPSS-26 software to get the desired results. Moreover, descriptive statistics through frequencies and percentages was executed to draw the findings and further discussions of the present study.
Results: The mean age of the national athletes was noted 34.17 years with 2.8 std. deviation and the age range was found between 30 to 38 years. The descriptive statistics of drug practices by national athletes calculated through occasionally, sometimes and frequently. Majority of the national athletes followed and practiced the trends of drugs while participating in their national games and championships to enhance their sport performance to approach the winning position and get the medals.
Conclusion: It was concluded that athletes may not aware the side effects and hazards of these drug practices using anabolic steroids, charas, marijuana, aspirin, cocaine, and heroin. National associations and federations should conduct seminars and awareness workshops for the athletes prior to their participation in sport competitions so that national athletes may save themselves from the side effects and afterwards physical damages.
Evaluation of the Association of Platelet Count, Mean Platelet Volume, and Platelet Transfusion With Intraventricular Hemorrhage and Death Among Preterm Infants
Authors: Chen Chong , Wu Sicheng , Chen Jia , Wu Jinghui , Mei Yabo , Han Tao , Yang Changshuan , Ouyang Xilin , Wong May Chun Mei , Feng Zhichun 
Published: October 2022

ImportancePlatelet transfusion is commonly performed in infants to correct severe thrombocytopenia or prevent bleeding. Exploring the associations of platelet transfusion, platelet count (PC), and mean platelet volume (MPV) with intraventricular hemorrhage (IVH) and in-hospital mortality in preterm infants can provide evidence for the establishment of future practices.ObjectivesTo evaluate the associations of platelet transfusion, PC, and MPV with IVH and in-hospital mortality and to explore whether platelet transfusion–associated IVH and mortality risks vary with PC and MPV levels at the time of transfusion.Design, Setting, and ParticipantsThis retrospective cohort study included preterm infants who were transferred to the neonatal intensive care unit on their day of birth and received ventilation during their hospital stay. The study was conducted at a neonatal intensive care unit referral center in Beijing, China, between May 2016 and October 2017. Data were retrieved and analyzed from December 2020 to January 2022.ExposuresPlatelet transfusion, PC, and MPV.Main Outcomes and MeasuresAny grade IVH, severe IVH (grade 3 or 4), and in-hospital mortality.ResultsAmong the 1221 preterm infants (731 [59.9%] male; median [IQR] gestational age, 31.0 [29.0-33.0] weeks), 94 (7.7%) received 166 platelet transfusions. After adjustment for potential confounders, platelet transfusion was significantly associated with mortality (hazard ratio [HR], 1.48; 95% CI, 1.13-1.93; P = .004). A decreased PC was significantly associated with any grade IVH (HR per 50 × 103/μL, 1.13; 95% CI, 1.05-1.22; P = .001), severe IVH (HR per 50 × 103/μL, 1.16; 95% CI, 1.02-1.32; P = .02), and mortality (HR per 50 × 103/μL, 1.74; 95% CI, 1.48-2.03; P &amp;lt; .001). A higher MPV was associated with a lower risk of mortality (HR, 0.83; 95% CI, 0.69-0.98; P = .03). The platelet transfusion–associated risks for both IVH and mortality increased when transfusion was performed in infants with a higher PC level (eg, PC of 25 × 103/μL: HR, 1.20; 95% CI, 0.89-1.62; PC of 100 × 103/μL: HR, 1.40; 95% CI, 1.08-1.82). The platelet transfusion–associated risks of IVH and mortality varied with MPV level at the time of transfusion.Conclusions and RelevanceIn preterm infants, platelet transfusion, PC, and MPV were associated with mortality, and PC was also associated with any grade IVH and severe IVH. The findings suggest that a lower platelet transfusion threshold is preferred; however, the risk of a decreased PC should not be ignored.
Efficacy and Safety of Ketamine vs Electroconvulsive Therapy Among Patients With Major Depressive Episode
Authors: Rhee Taeho Greg , Shim Sung Ryul , Forester Brent P. , Nierenberg Andrew A. , McIntyre Roger S. , Papakostas George I. , Krystal John H. , Sanacora Gerard , Wilkinson Samuel T. 
Published: October 2022

ImportanceWhether ketamine is as effective as electroconvulsive therapy (ECT) among patients with major depressive episode remains unknown.ObjectiveTo systematically review and meta-analyze data about clinical efficacy and safety for ketamine and ECT in patients with major depressive episode.Data SourcesPubMed, MEDLINE, Cochrane Library, and Embase were systematically searched using Medical Subject Headings (MeSH) terms and text keywords from database inception through April 19, 2022, with no language limits. Two authors also manually and independently searched all relevant studies in US and European clinical trial registries and Google Scholar.Study SelectionIncluded were studies that involved (1) a diagnosis of depression using standardized diagnostic criteria, (2) intervention/comparator groups consisting of ECT and ketamine, and (3) depressive symptoms as an efficacy outcome using standardized measures.Data Extraction and SynthesisData extraction was completed independently by 2 extractors and cross-checked for errors. Hedges g standardized mean differences (SMDs) were used for improvement in depressive symptoms. SMDs with corresponding 95% CIs were estimated using fixed- or random-effects models. The Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) reporting guideline was followed.Main Outcomes and MeasuresEfficacy outcomes included depression severity, cognition, and memory performance. Safety outcomes included serious adverse events (eg, suicide attempts and deaths) and other adverse events.ResultsSix clinical trials comprising 340 patients (n = 162 for ECT and n = 178 for ketamine) were included in the review. Six of 6 studies enrolled patients who were eligible to receive ECT, 6 studies were conducted in inpatient settings, and 5 studies were randomized clinical trials. The overall pooled SMD for depression symptoms for ECT when compared with ketamine was −0.69 (95% CI, −0.89 to −0.48; Cochran Q, P = .15; I2 = 39%), suggesting an efficacy advantage for ECT compared with ketamine for depression severity. Significant differences were not observed between groups for studies that assessed cognition/memory or serious adverse events. Both ketamine and ECT had unique adverse effect profiles (ie, ketamine: lower risks for headache and muscle pain; ECT: lower risks for blurred vision, vertigo, diplopia/nystagmus, and transient dissociative/depersonalization symptoms). Limitations included low to moderate methodological quality and underpowered study designs.Conclusions and RelevanceFindings from this systematic review and meta-analysis suggest that ECT may be superior to ketamine for improving depression severity in the acute phase, but treatment options should be individualized and patient-centered.