bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical characteristics and outcomes of phase I cancer patients with CCNE1 amplification: MD Anderson experiences
Authors: Yao Shuyang , Meric-Bernstam Funda , Hong David , Janku Filip , Naing Aung , Piha-Paul Sarina Anne , Tsimberidou Apostolia Maria , Karp Daniel , Subbiah Vivek , Yap Timothy Anthony , Ahnert Jordi Rodon , Pant Shubham , Dumbrava Ecaterina E Ileana , Wathoo Chetna , Campbell Erick , Yu Lihou , Yamamura Yuko , Fu Siqing 
Published: May 2022

AbstractCyclin E is frequently encoded by CCNE1 gene amplification in various malignancies. We reviewed the medical records of patients with solid tumors displaying CCNE1 amplification to determine the effect of this amplification for future therapeutic development. We reviewed the medical records of patients with advanced solid tumors harboring CCNE1 amplification who were seen at the phase I clinic between September 1, 2012, and December 31, 2019. Among 79 patients with solid tumors harboring CCNE1 amplification, 56 (71%) received phase 1 clinical trial therapy, 39 (49%) had 3 or more concurrent genomic aberrances, and 52 (66%) had a concurrent TP53 mutation. The median overall survival (OS) after patients’ initial phase I visit was 8.9 months and after their initial metastasis diagnosis was 41.4 months. We identified four factors associated with poor risk: age < 45 years, body mass index ≥ 25 kg/m2, presence of the TP53 mutation, and elevated LDH > upper limit of normal. In patients treated with gene aberration-related therapy, anti-angiogenic therapy led to significantly longer OS after their initial phase I trial therapy than those who did not: 26 months versus 7.4 months, respectively (P = 0.04). This study provided preliminary evidence that CCNE1 amplification was associated with frequent TP53 mutation and aggressive clinical outcomes. Survival benefit was observed in patients who received antiangiogenic therapy and gene aberration-related treatment, supporting the future development of a personalized approach to combine gene aberration-related therapy with antiangiogenesis for the treatment of advanced malignancies harboring CCNE1 amplification.
Effects of physical activity intervention on 24-h movement behaviors: a compositional data analysis
Authors: Pasanen Jesse , Leskinen Tuija , Suorsa Kristin , Pulakka Anna , Virta Joni , Auranen Kari , Stenholm Sari 
Published: May 2022

AbstractWe utilized compositional data analysis (CoDA) to study changes in the composition of the 24-h movement behaviors during an activity tracker based physical activity intervention. A total of 231 recently retired Finnish retirees were randomized into intervention and control groups. The intervention participants were requested to use a commercial activity tracker bracelet with daily activity goal and inactivity alerts for 12 months. The controls received no intervention. The 24-h movement behaviors, i.e., sleep, sedentary time (SED), light physical activity (LPA), and moderate-to-vigorous physical activity (MVPA) were estimated from wrist-worn ActiGraph data using the GGIR R-package. Three balance coordinates describing the composition of movement behaviors were applied: ratio of active vs. passive behaviors, LPA vs. MVPA, and sleep vs. SED. A linear mixed model was used to study changes between the baseline and 6-month time point. Overall, the changes in the 24-h movement behaviors were small and did not differ between the groups. Only the ratio of LPA to MVPA tended to change differently between the groups (group*time interaction p = 0.08) as the intervention group increased LPA similarly to controls but decreased their MVPA. In conclusion, the use of a commercial activity tracker may not be enough to induce changes in the 24-h movement behaviors among retirees.
Diversity of the virome associated with alfalfa (Medicago sativa L.) in the U.S. Pacific Northwest
Authors: Nemchinov Lev G. , Irish Brian M. , Grinstead Samuel , Shao Jonathan , Vieira Paulo 
Published: May 2022

AbstractAlfalfa (Medicago sativa L.) is one of the most extensively cultivated forage legumes in the world. It is currently the third most valuable field crop in the United States with an estimated value of over $9.3 billion. Alfalfa productivity is limited by various infectious diseases that can reduce forage yield and quality and shorten stand life. The crop can frequently be infected with a diverse array of pathogens and other organisms that have distinct life cycles, biology, and mode of action. Among them are many coinfecting viruses, that greatly contribute to the heterogeneity of within-host pathogenic communities, representing a ubiquitous and abundant background for all other host–pathogen interactions. Regrettably, the impact of viral diseases, their role in alfalfa health and involvement in the severity of multi-pathogen infections are often underestimated and not well understood. As high-throughput sequencing approaches have been developed, opportunities to delve into these complex interactions can be realized. In this work, we have characterized a diversity of viral populations in several commercial alfalfa production fields located in the U.S. Pacific Northwest. At least 45 distinct viruses have been identified in all alfalfa samples. Among them some were known to infect the crop prior to this study, and others were designated as emerging, novel and viruses integrated into the alfalfa genome. Known viruses included alfalfa mosaic virus, pea streak virus and bean leafroll virus, while among emerging and novel agents were alfalfa virus S, cherry virus Trakiya, several rhabdoviruses and others. Additional biological and impact studies will be needed to determine if newly identified viruses, especially those that have not been reported from alfalfa before, should be considered pathogens of this crop.
Constructing rapid water vapor transport channels within mixed matrix membranes based on two-dimensional mesoporous nanosheets
Authors: Wang Fengkai , Han Shurui , Zhang Yanli , Gao Lei , Li Xu , Zhao Lizhi , Ye Hui , Li Hong , Xin Qingping , Zhang Yuzhong 
Published: May 2022

AbstractMembrane technology is an effective strategy for gas dehumidification and fuel cell humidification. In this study, cerium fluoride oxide (F-Ce) two-dimensional (2D) mesoporous nanosheets and their composite with 1-ethyl-3-methylimidazolium dicyanamide ([Emim][DCA]) ionic liquids (ILs) (IL@F-Ce) are introduced as fillers into polyether block amide (PEBAX® 1074) to fabricate mixed matrix membranes (MMMs). The slit-shaped mesoporous structure of the nanosheets facilitates the construction of water vapor rapid transport channels in MMMs. The permeability and selectivity of water vapor for MMMs loaded with F-Ce nanosheets are greatly improved, and the performance of MMMs loaded with IL@F-Ce nanosheets are much better than the former. Particularly, the MMM with IL@F-Ce content of 4 wt.% achieves the highest H2O permeability of 4.53 × 105 Barrer, which is more than twice that of the pure PEBAX membrane, and the selectivity is increased by 83%. Thus, the MMMs based on 2D mesoporous nanosheets have considerable potential application in industrial-scale dehydration and humidification processes.
Glyceryl butyrate attenuates enterotoxigenic Escherichia coli-induced intestinal inflammation in piglets by inhibiting the NF-κB/MAPK pathways and modulating the gut microbiota
Authors: Tian Min , Li Lilang , Tian Zhezhe , Zhao Hao , Chen Fang , Guan Wutai , Zhang Shihai 
Published: May 2022

Glyceryl butyrate attenuated the immune-inflammatory response in piglets challenged with enterotoxigenic Escherichia coli (ETEC) by inhibiting the NF-κB/MAPK pathways and modulating the gut microbiota, and thus improved piglet intestinal health.
Autophagy in asthma and chronic obstructive pulmonary disease
Authors: Barnes Peter J. , Baker Jonathan , Donnelly Louise E. 
Published: May 2022

Abstract
Autophagy (or macroautophagy) is a key cellular process that removes damaged molecules (particularly proteins) and subcellular organelles to maintain cellular homeostasis. There is growing evidence that abnormalities in autophagy may contribute to the pathogenesis of many chronic diseases, including asthma and chronic obstructive pulmonary disease (COPD). In asthma, increased autophagy plays a role in promoting type 2 immune responses and eosinophilic inflammation, whereas decreased autophagy may be important in neutrophilic asthma. Acute exposure to cigarette smoke may activate autophagy, resulting in ciliary dysfunction and death of airway epithelial cells, whereas in stable COPD most studies have demonstrated an impairment in autophagy, with reduced autophagic flux and accumulation of abnormal mitochondria (defective mitophagy) and linked to cellular senescence. Autophagy may be increased or decreased in different cell types and depending on the cellular environment, making it difficult to target autophagy therapeutically. Several existing drugs may activate autophagy, including rapamycin, metformin, carbamazepine, cardiac glycosides and statins, whereas others, such as chloroquine, inhibit this process. However, these drugs are nonspecific and more selective drugs are now in development, which may prove useful as novel agents to treat asthma and COPD in the future.
Generalised predictive controller (GPC) design on single‐phase full‐bridge inverter with a novel identification method
Authors: Memeghani Mehran Jelodari , Ghamari Seyyed Morteza , Jouybari Taha Yousefi , Mollaee Hasan , Wheeler Patrick 
Published: May 2022

AbstractThe design of an on‐line generalised predictive control (GPC) technique with a novel identification method is presented in this paper for a single‐phase full‐bridge inverter in the presence of different disturbances. The controller uses system discrete‐time model to reach the control variables with a prediction over these values, followed by computing a cost function for control aims. However, in this controller, the need for the mathematical model of the system is removed since the black‐box identification strategy is used. Moreover, GPC structure has many advantages including low computational complexity, systematic design procedure, and fixed switching frequency that makes it a good alternative for practical applications. Various disturbances can have a negative impact on a DC–AC inverter; thus, considering robust dynamics and ease of implantation, the GPC scheme is used along with an improved exponential regressive least square identification algorithm as an adaptive strategy in the controller. Moreover, the prediction horizons of this controller have been increased, resulting in its low steady‐state error and better performance. Furthermore, harmonics in the sinusoidal signal can decrease the total efficiency of the system; thus, an LC filter is used to reduce the level of total harmonic distortion. However, the stability of the filter is the most challenging issue in designing a suitable controller. Finally, the strength of the current controller is verified using experimental and simulations results.
Current interruption tests of HVDC circuit‐breakers: Requirements, methods and a testing case
Authors: Jia Shenli , Tang Qiang , Xiu Shixin , Long Zhisong , Qin Ke , Shi Zongqian , Mo Yongpeng 
Published: May 2022

AbstractDevelopment towards HVDC grids is drawing intense development of HVDC circuit‐breakers (CBs). The increasing rated voltage and capacity requires HVDC CBs with excellent performance to be installed and comprehensive tests on HVDC CBs are indispensable. This paper contributes to clarifying clearer test requirements on the current interruption test, which is the most challenging one and proposing a novel applicable test method. It is the toughest test because when an HVDC CB interrupts fault current, a high transient interruption voltage (TIV) is produced by the operation of metal oxide surge arrester (MOSA), and a large current continues flowing through MOSA simultaneously, which means considerable energy is demanded for the test. To verify an HVDC CB's current interruption ability, voltage withstand ability and energy dissipation ability in single test can be costly and even impractical in extra high voltage classes. Alternatively, a multi‐part test method is reasonable and valuable, in which the HVDC CB can be tested with large current and high voltage one after another, while the energy dissipation ability will be verified separately. At last, a proposed synthetic test circuit is validated by a simulation and a low voltage experiment, creating high equivalence between the simulation and the validation test.
Top-down formation of ethylene from fragmentation of superhydrogenated polycyclic aromatic hydrocarbons
Authors: Tang Zeyuan , Simonsen Frederik Doktor S. , Jaganathan Rijutha , Palotás Julianna , Oomens Jos , Hornekær Liv , Hammer Bjørk 
Published: May 2022

Context. Fragmentation is an important decay mechanism for polycyclic aromatic hydrocarbons (PAHs) under harsh interstellar conditions and represents a possible formation pathway for small molecules such as H2, C2H2, and C2H4.
Aims. Our aim is to investigate the dissociation mechanism of superhydrogenated PAHs that undergo energetic processing and the formation pathway of small hydrocarbons.
Methods. We obtain, experimentally, the mass distribution of protonated tetrahydropyrene (C16H15+, [py + 5H]+) and protonated hex-ahydropyrene (C16H17+, [py + 7H]+) upon collision-induced dissociation (CID). The infrared (IR) spectra of their main fragments are recorded by infrared multiple-photon dissociation (IRMPD). Extended tight-binding (GFN2-xTB) based molecular dynamics (MD) simulations were performed in order to provide the missing structure information for this experiment and to identify fragmentation path ways. The pathways for fragmentation were further investigated at a hybrid density functional theory (DFT) and dispersion-corrected level.
Results. A strong signal for loss of 28 mass units of [py + 7H]+ is observed both in the CID experiment and the MD simulation, while [py + 5H]+ shows a negligible signal for the product corresponding to a mass loss of 28. The 28 mass loss from [py + 7H]+ is assigned to the loss of ethylene (C2H4) and a good fit between the calculated and experimental IR spectrum of the resulting fragment species is obtained. Further DFT calculations show favorable kinetic pathways for loss of C2H4 from hydrogenated PAH configurations involving three consecutive CH2 molecular entities.
Conclusions. This joint experimental and theoretical investigation proposes a chemical pathway of ethylene formation from fragmentation of superhydrogenated PAHs. This pathway is sensitive to hydrogenated edges (e.g., the degree of hydrogenation and the hydrogenated positions). The inclusion of this pathway in astrochemical models may improve the estimated abundance of ethylene.
Properties of the ionisation glitch
Authors: Houdayer Pierre S. , Reese Daniel R. , Goupil Marie-Jo 
Published: May 2022

Aims. In the present paper, we aim to constrain the properties of the ionisation region of a star from the oscillation frequency variation (a so-called glitch) caused by rapid structural variations in this very region. In particular, we seek tof avoid the use of calibration based on stellar models, thus providing a truly independent estimate of these properties. These include both the helium abundance and other physical quantities that can have a significant impact on the oscillation frequencies, such as the electronic degeneracy parameter or the extent of the ionisation region.
Methods. Building on previous findings, we applied structural perturbations of the ionisation zone to the wave equation for radial oscillations in an isentropic region. The resulting glitch model is thus able to exploit the information contained in the fast frequency oscillation caused by the helium ionisation but also that in the slow trend accompanying the ionisation of hydrogen. This information can be directly expressed in terms of parameters related to the helium abundance, electronic degeneracy, and the extent of the ionisation region, respectively.
Results. Using Bayesian inference, we show that substantial recovery of the properties at the origin of the glitch is possible. We find a degeneracy between the helium abundance and the electronic degeneracy, which particularly affects the helium estimate. Extending the method to cases where the glitch is subject to contamination (e.g., surface effects), we note the importance of the slow glitch trend associated with hydrogen ionisation. We propose the use of a Gaussian process to disentangle the frequency glitch from surface effects.
Brachial Plexus Birth Palsy: Practical Concepts for Radiologists
Authors: González-Mantilla Pedro , Abril Angela , Bedoya Maria Alejandra 
Published: May 2022

AbstractBrachial plexus birth palsy (BPBP) is classified as a preganglionic or postganglionic injury based on the site of injury. Most patients recover spontaneously and are followed up with clinical evaluation; however, permanent sequelae are not uncommon. For patients with persistent neurologic deficits, clinical and radiologic evaluation is crucial. Untreated BPBP can progress to significant sequelae, such as muscle contractures and glenohumeral dysplasia (GHD). Timely characterization of these entities based on different imaging modalities is a high priority for optimal patient outcomes. We describe the anatomy and pathogenesis, as well as the different imaging modalities involved in the evaluation and classification of BPBP and GHD.
Mario Campanacci, 1932-1999
Authors: Bazzocchi Alberto , Campanacci Laura , Aparisi Gómez Maria Pilar , Guglielmi Giuseppe 
Published: May 2022

AbstractThis history page in the series “Leaders in Musculoskeletal Radiology” is dedicated to the memory and achievements of the Italian scientist Mario Campanacci, whose name is connected to the medical eponym Jaffe-Campanacci syndrome and to the field and progress of musculoskeletal oncology.
Ancient proteins resolve controversy over the identity ofGenyorniseggshell
Authors: Demarchi Beatrice , Stiller Josefin , Grealy Alicia , Mackie Meaghan , Deng Yuan , Gilbert Tom , Clarke Julia , Legendre Lucas J. , Boano Rosa , Sicheritz-Pontén Thomas , Magee John , Zhang Guojie , Bunce Michael , Collins Matthew James , Miller Gifford 
Published: May 2022

The realization that ancient biomolecules are preserved in “fossil” samples has revolutionized archaeological science. Protein sequences survive longer than DNA, but their phylogenetic resolution is inferior; therefore, careful assessment of the research questions is required. Here, we show the potential of ancient proteins preserved in Pleistocene eggshell in addressing a longstanding controversy in human and animal evolution: the identity of the extinct bird that laid large eggs which were exploited by Australia’s indigenous people. The eggs had been originally attributed to the iconic extinct flightless birdGenyornis newtoni(†Dromornithidae, Galloanseres) and were subsequently dated to before 50 ± 5 ka by Miller et al. [Nat. Commun.7, 10496 (2016)]. This was taken to represent the likely extinction date for this endemic megafaunal species and thus implied a role of humans in its demise. A contrasting hypothesis, according to which the eggs were laid by a large mound-builder megapode (Megapodiidae, Galliformes), would therefore acquit humans of their responsibility in the extinction ofGenyornis. Ancient protein sequences were reconstructed and used to assess the evolutionary proximity of the undetermined eggshell to extant birds, rejecting the megapode hypothesis. Authentic ancient DNA could not be confirmed from these highly degraded samples, but morphometric data also support the attribution of the eggshell toGenyornis. When used in triangulation to address well-defined hypotheses, paleoproteomics is a powerful tool for reconstructing the evolutionary history in ancient samples. In addition to the clarification of phylogenetic placement, these data provide a more nuanced understanding of the modes of interactions between humans and their environment.
Non-coherent cohesive texts
Authors: Abu-Ayyash Emad A. S. 
Published: May 2022

AbstractThis article examines the function of cohesive devices (i.e., the linguistic tools that are usually used to link the various parts of the text) in Beckett’sWaiting for Godot. In Lucky’s soliloquy, certain cohesive devices are employed intensively so as to impede immediate understanding. At the same time, Beckett’s distinctive use of cohesive devices uniquely establishes a more profound awareness of the work’s message, which this article identifies as strategic coherence. This paper employed an embedded (QUAL:quan) mixed-methods approach and a validated model of cohesion to analyse Lucky’s speech.
A cartography of translation
Authors: Hofeneder Philipp 
Published: May 2022

AbstractSpace as an epistemological category has a long history within the humanities in general and has attracted increasing attention more recently in translation studies. It has come to be understood predominantly as a discursive category (e.g., cultural spaces in a figurative sense) and the product of social interactions (cf. the relationship between agents). This contribution focuses for the first time on the physical movement within an eminent translatorial project at the beginning of the 19th century in Russia. Where do these translators come from, where do they move to and where do they leave after finishing the translation? In addressing those questions, this case study brings to the fore the relevant spatial relations of translators, translations and other agents engaged in a translation. Several thematic maps are produced, which are helpful for visualizing these movements in space and for situating a translation space in the context of its physical surroundings.
Determination of the solution of a stochastic parabolic equation by the terminal value
Authors: Dou Fangfang , Du Wanli 
Published: May 2022

Abstract
This paper studies the inverse problem of determination the history for a stochastic diffusion process, by means of the value at the final time T. By establishing a new Carleman estimate, the conditional stability of the problem is proven. Based on the idea of Tikhonov method, a regularized solution is proposed. The analysis of the existence and uniqueness of the regularized solution, and proof for error estimate under an a priori assumption are present. Numerical verification of the regularization, including numerical algorithm and examples are also illustrated.
Effect of spin–orbit interaction on circular current: pure spin current phenomena within a ring conductor
Authors: Patra Moumita 
Published: May 2022

Abstract
A net circulating current may appear within a quantum ring under finite bias. We study the characteristic features of the circular current in the presence of Rashba spin–orbit interaction (RSOI). Both charge and spin currents appear within the ring. Whereas when the ring is symmetrically connected to the external leads, we can get a pure spin current at non-zero Fermi-energy. On the other hand, for asymmetric ring-to-leads configuration, at zero Fermi-energy, the spin current vanishes but a pure charge current flows within the ring. Tuning RSOI, we demonstrate a way to control the pure spin current externally. This new perspective of the generation of the pure spin circular current can open a new basis for the highly efficient, low energy cost spintronic devices.