bluuebunny/crossref_metadata_2025_split huggingface dataset:
Quality improvement of saliva by chewing tapioca pearls in bubble tea drinks: a randomized experimental trial
Authors: Handajani Juni , Kusumajati Dinda , Fathiyah Hania , Susilowati Heni , Tandelilin Regina T.C. 
Published: March 2022

Background: Bubble tea drinks contain tea and tapioca pearls. Chewing tapioca pearls in bubble tea drinks may increase salivary components. Because of its proteins, inorganic components, and enzymes, saliva plays an important role in the body’s defense against bacteria and viruses. This study aims to analyze the effect of chewing tapioca pearls in bubble tea drinks on salivary C-reactive protein (CRP) and calcium (Ca) levels. Methods: The inclusion criterion was 18–25 years of age. The exclusion criteria were receiving medication, using dentures, a history of dry mouth, smoking and systemic disease. In the first week of the experiment, subjects drank bubble tea with tapioca pearls for three days (intervention week). In the second week, the same subjects drank tea without pearls for three days (control week). Each subject drank the bubble tea for 5 minutes per day over 3 days. Saliva samples were collected on the first day before bubble tea consumption (pretest) and on the third day after tea consumption (posttest). Saliva collection was performed in the morning (09:00 am–12:00 pm) for 1 minute. Sixty saliva samples were collected from 15 subjects. Salivary CRP levels were measured using a commercial ELISA kit, and Ca levels were determined using semi-quantitative test strips. Results: Salivary CRP decreased significantly on the third day in the intervention group but showed no significant difference with the control group. Calcium levels increased significantly on the third day in both groups. Conclusion: Bubble tea drinks could improve the quality of saliva by decreasing salivary CRP and increasing Ca levels. Trial registration: ClinicalTrials.gov, NCT04670341 (17th December 2020).
Examining graphemic and lexical anglicisms in Twi for academic purposes in textbooks written in Twi
Authors: Akoto Osei Yaw , Marfo Charles Ofosu , Ansah Juliet Oppong-Asare , Fordjour Emmanuel Antwi , Forson Isaac Adjei 
Published: March 2022

This paper examines graphemic and lexical borrowings in Twi for Academic Purposes (TAP). Textbooks written in Asante Twi by some renowned scholars in the language constituted the dataset for this study. The textbooks were read and all instances of anglicisms or English features borrowed into Twi were collected. The borrowed-features were identified by drawing on our native speaker and scholarly competencies. The dataset was analyzed by drawing on Clyne’s (1977) Borrowing Typology and Haugen’s (1950) Borrowability Scale. Three key findings emerged from the analysis. First, the study yielded that in TAP two letters (<v>, and <j>) are borrowed towards empowering Asante Twi to enable it to account for words that contain these letters. Second, at the lexical level, it was found that the borrowed words were either integrated or adapted into Asante Twi linguistic environment. The final point was that all the lexical items realized were nominals affirming the primacy of noun on borrowability scales. The findings have implications for developing Ghanaian languages for academic purposes.
Noise reduction in a Brillouin optical time-domain sensor by a frequency-domain feature filter
Authors: Yuan Pei , Lu Yuangang , Zhang Yuyang , Zhang Zelin 
Published: March 2022

A novel frequency-domain image processing method is proposed, to the best of our knowledge, to filter the noise from data collected by distributed optical fiber sensors based on Brillouin optical time-domain sensing (BOTDS). In the proposed method, we first divide a data image into subimages, and then we filter the noisy subimages by retaining the useful frequency information corresponding to the Lorentz-shape frequency spectrum and Brillouin frequency shift (BFS) transitions. The denoising performance improvements are verified by simulation and experiment. The performances in terms of temperature/strain measurement uncertainty, spatial resolution, and processing time achieved by the proposed filter are then compared with those by using a Gaussian filter and a nonlocal means (NLM) filter. In a proof-of-concept experiment with a 5.2 km length G657 sensing fiber, we achieve a temperature measurement uncertainty improvement of 27% compared with the results obtained by using the Gaussian filtering method. Furthermore, the processing speed of the proposed method is 22 times faster than that of the NLM filter under the same temperature measurement uncertainty.
Bayesian calibration, process modeling and uncertainty quantification in biotechnology
Authors: Helleckes Laura Marie , Osthege Michael , Wiechert Wolfgang , von Lieres Eric , Oldiges Marco 
Published: March 2022

High-throughput experimentation has revolutionized data-driven experimental sciences and opened the door to the application of machine learning techniques. Nevertheless, the quality of any data analysis strongly depends on the quality of the data and specifically the degree to which random effects in the experimental data-generating process are quantified and accounted for. Accordingly calibration, i.e. the quantitative association between observed quantities and measurement responses, is a core element of many workflows in experimental sciences.Particularly in life sciences, univariate calibration, often involving non-linear saturation effects, must be performed to extract quantitative information from measured data. At the same time, the estimation of uncertainty is inseparably connected to quantitative experimentation. Adequate calibration models that describe not only the input/output relationship in a measurement system but also its inherent measurement noise are required. Due to its mathematical nature, statistically robust calibration modeling remains a challenge for many practitioners, at the same time being extremely beneficial for machine learning applications.In this work, we present a bottom-up conceptual and computational approach that solves many problems of understanding and implementing non-linear, empirical calibration modeling for quantification of analytes and process modeling. The methodology is first applied to the optical measurement of biomass concentrations in a high-throughput cultivation system, then to the quantification of glucose by an automated enzymatic assay. We implemented the conceptual framework in two Python packages,calibr8andmurefi, with which we demonstrate how to make uncertainty quantification for various calibration tasks more accessible. Our software packages enable more reproducible and automatable data analysis routines compared to commonly observed workflows in life sciences.Subsequently, we combine the previously established calibration models with a hierarchical Monod-like ordinary differential equation model of microbial growth to describe multiple replicates ofCorynebacterium glutamicumbatch cultures. Key process model parameters are learned by both maximum likelihood estimation and Bayesian inference, highlighting the flexibility of the statistical and computational framework.
Future prevalence of type 2 diabetes—A comparative analysis of chronic disease projection methods
Authors: Voeltz Dina , Tönnies Thaddäus , Brinks Ralph , Hoyer Annika 
Published: March 2022

Background
Accurate projections of the future number of people with chronic diseases are necessary for effective resource allocation and health care planning in response to changes in disease burden.

Aim
To introduce and compare different projection methods to estimate the number of people with diagnosed type 2 diabetes (T2D) in Germany in 2040.

Methods
We compare three methods to project the number of males with T2D in Germany in 2040. Method 1) simply combines the sex- and age-specific prevalence of T2D in 2010 with future population distributions projected by the German Federal Statistical Office (FSO). Methods 2) and 3) additionally account for the incidence of T2D and mortality rates using partial differential equations (PDEs). Method 2) models the prevalence of T2D employing a scalar PDE which incorporates incidence and mortality rates. Subsequently, the estimated prevalence is applied to the population projection of the FSO. Method 3) uses a two-dimensional system of PDEs and estimates future case numbers directly while future mortality of people with and without T2D is modelled independently from the projection of the FSO.

Results
Method 1) projects 3.6 million male people with diagnosed T2D in Germany in 2040. Compared to 2.8 million males in 2010, this equals an increase by 29%. Methods 2) and 3) project 5.9 million (+104% compared to 2010) and 6.0 million (+116%) male T2D patients, respectively.

Conclusions
The results of the three methods differ substantially. It appears that ignoring temporal trends in incidence and mortality may result in misleading projections of the future number of people with chronic diseases. Hence, it is essential to include these rates as is done by method 2) and 3).
Tuning parameters for the synthesis of MIL-53(Al): Mn doped MIL-53(Al) as a high potential catalyst for methanol dehydration
Authors: Kazemzadeh Nasrin , Halladj Rouein , Askari Sima , Kia Raza 
Published: March 2022

Abstract
Recently, many studies are dealing with developments of Metal-Organic Frameworks (MOFs), especially MIL-53(Al), which shows high thermal and mechanical stability. Among these, optimizing the synthesis condition of MIL-53(Al) to obtain appropriate characteristics has attracted much attention in academia and the industry. Here, the effect of synthesis time and ligand to metal molar ratio on the hydrothermal synthesis of MIL-53(Al) are pursued. The synthesized MIL-53(Al) samples are characterized by X-ray diffraction (XRD), the Fourier transform infrared spectroscopy (FTIR), scanning electron microscope (SEM), energy dispersive X-ray analysis (EDX), thermal gravimetric analysis (TGA), and nitrogen adsorption-desorption technique (BET). The present study shows that MIL-53(Al) can be conventionally synthesized with a high yield within a shorter reaction time than the previous studies. Furthermore, the catalytic activity of the optimized MIL-53(Al) in the pure and Mn-doped form is studied in a methanol dehydration reaction. It is thus inferred that this popular MOF in the Mn/MIL-53(Al) form has a high activity and DME selectivity during methanol conversion. Our present results confirm the merits of employing the MIL-53(Al) as a catalyst in methanol to DME conversion, which can be an avenue for the practical application of acidic catalyst.
Comparison of in-hospital mortality of COVID-19 between pregnant and non-pregnant women infected with SARS-CoV-2: a historical cohort study
Authors: Zare Marjan , Mirahmadizadeh Alireza , Akbari Mahsa , Moradian Mohammad Javad 
Published: March 2022

Abstract

Objectives
This study aimed to compare pregnant and non-pregnant women infected with SARS-CoV-2 disease (COVID-19) in terms of in-hospital mortality.

Methods
This historical cohort study was conducted on hospitalized women of reproductive ages (15–49 years) infected with SARS-CoV-2 in Fars province, Iran during 15 March 2019–10 May 2021.

Results
Out of the 5,322 patients, 330 were pregnant. The fatality rate of SARS-CoV-2 was 1.2% amongst pregnant women and 3.5% amongst non-pregnant ones. Pregnant and non-pregnant women reported the same history of smoking, opium use, previous COVID-19 infection, vaccination against SARS-CoV-2, and COVID-19 symptoms (p>0.05 for all). However, the pregnant women were younger and had fewer underlying diseases (p<0.001 for both). The results revealed no significant difference between the two groups regarding in-hospital clinical manifestations including the number of days after the onset of COVID-19 symptoms, mechanical ventilation, and long involvement (cRR; 95% CI=0.99 (0.96–1.02), 1.18 (0.72–2.02), and 0.95 (0.88–1.02), respectively). Nonetheless, Intensive Care Unit (ICU) admission was significantly higher in pregnant women (cRR; 95% CI=2.37(1.85–3.02)). After adjusting for age, history of underlying diseases, and ICU admission, pregnant women showed lower in-hospital mortality due to COVID-19 compared to non-pregnant women (aRR; 95% CI=0.32 (0.12–0.87)).

Conclusions
Based on the current study findings, pregnant women showed lower in-hospital mortality due to COVID-19 compared to non-pregnant ones. Nevertheless, they should follow the same recommendations as non-pregnant women, avoiding exposure to the virus and receiving medical treatment and vaccination. Further studies are recommended to address the follow-up of recovered pregnant women, their babies, and puerperium.
COVID-era sociolinguistics: introduction to the special issue
Authors: Sneller Betsy 
Published: March 2022

Abstract
In the 18 months that have passed since COVID-19 was declared a global pandemic, linguists around the world have had to grapple with the practical and ethical issues that arose from trying to collect data in a safe and remote way while participants are experiencing an acute disaster. The current collection presents insights from a number of sociolinguistic research projects that were either initiated in response to the pandemic or that adjusted their research methods mid-trajectory. A concluding discussion article underscores that the honest reflections and concrete suggestions in this collection will remain relevant beyond the COVID-19 pandemic. They will be of value to any (socio)linguist who is navigating the ethics of fieldwork in uncertain or traumatic contexts, who is recruiting and retaining participants via remote means, or who is figuring out how to rapidly change their data collection methods.
Institutions and Moral Demandingness
Authors: Belic Jelena 
Published: March 2022

Abstract
How much should we sacrifice for the sake of others? While some argue in favour of significant sacrifices, others contend that morality cannot demand too much from individuals. Recently, the debate has taken a new turn by focusing on moral demands under non-ideal conditions in which the essential interests of many people are set back. Under such conditions, in some views, moral theories must require extreme moral demands as anything less is incompatible with equal consideration of everyone’s interests. The insistence on the extremeness of moral demands, however, presupposes a simplistic account of non-ideal conditions as characterized mainly by the non-compliance of many individuals. Non-ideal conditions are also characterized by institutional non-compliance, whereby institutions often do not do what they ought to do. Institutional non-compliance is significant as it increases the size of moral demands significantly, thereby exacerbating the conflict between these demands and the self-interest of individuals subjected to these institutions. I argue that individuals have a meta-interest in not experiencing such internal conflicts as these can undermine their affirmation of self-respect. Meta-interest can be advanced by adopting the promotion of just institutions as an ultimate aim, as such institutions lessen the conflict and, accordingly, enable us to live more harmonious lives. Moreover, the promotion of just institutions allows us to affirm our sense of self-respect under non-ideal conditions too. Because the promotion of just institutions is in our self-interest, this is not an extreme but a moderate moral demand.
The role of relaxation and retardation phenomenon of Oldroyd-B fluid flow through Stehfest’s and Tzou’s algorithms
Authors: Awan Aziz Ullah , Riaz Samia , Abro Kashif Ali , Siddiqa Ayesha , Ali Qasim 
Published: March 2022

Abstract
Delayed response (delay of the elasticity) and time needed for initial stress can lead to relaxation and retardation phenomenon; this is because of the consistent behavior of viscoelastic fluid on thermodynamic principles. In this context, the aim of this article is to investigate the unsteady, incompressible, and Oldroyd-B viscoelastic fluid under wall slip conditions to know the hidden aspects of relaxation and retardation. The motion of the liquid is assumed over a flat vertical plate which moves through an oscillating velocity. A fractional model is developed by using the modern definition of the non-singular kernel proposed by Caputo and Fabrizio. We have obtained a semi-analytical solution of the non-dimensional model by using the Laplace transformation that satisfies our imposed suitable boundary conditions. We have tackled the Laplace inverse by employing Stehfest’s and Tzou’s algorithms. The velocity is enhanced by decreasing the estimations of relaxation time λ as well as slip parameter, and the temperature is also increasing for a considerable measure of the fractional factor. The effects of different fractional and physical parameters are plotted using Mathcad software based on the relaxation and retardation phenomenon of Oldroyd-B viscoelastic fluid.
Covid-19 und das Arbeitsmarktverhalten von Frauen und Männern
Authors: Tertilt Michèle 
Published: March 2022

Zusammenfassung
In Folge von Covid-19 sind bisher mehr Männer als Frauen gestorben.1 Aber wirtschaftlich sind Frauen von der Pandemie stärker betroffen als Männer. In ihrer Thünen-Vorlesung vor dem Verein für Socialpolitik im Herbst 2021 erläutert Michèle Tertilt die Auswirkungen der Corona-Pandemie auf das Arbeitsmarktverhalten von Frauen und Männern und die sich dadurch ergebenden langfristigen Konsequenzen. Tertilt berichtet zunächst von einer empirischen Studie, in der sie gemeinsam mit Koautoren untersucht hat, inwieweit sich das relative Arbeitsangebot von Frauen und Männern in der Pandemie in einer Reihe von Ländern verändert hat. Sie stellt außerdem Ergebnisse eines quantitativen Modells vor, das die mittel- und langfristigen Konsequenzen der Pandemie für die Geschlechtergerechtigkeit am Arbeitsmarkt und insbesondere für das Lohngefälle vorhersagen soll.
Nextness and story organization: ‘my day’ sequences in parent-child interaction
Authors: Kim Younhee , Carlin Andrew P. 
Published: March 2022

AbstractIn this paper we offer a longitudinal Conversation Analysis of talk lasting 18 months between a father and son, which reveals changes in the child’s level of Interactional Competence (IC). We propose an index of developing IC based upon Sacks’ distinction between “invited” and “volunteered” stories. While stories have a “socialization function” we suggest stories may be tracked in terms of IC also. What has been called “today narrative” routines (“What did you do at school today”, etc.), initiated by the father, predominate in a series of conversations. The analysis reveals how the child is encouraged to take extended turns through the father’s questions and comments, which are developed into a storytelling sequence. We observe that the child’s responses to the initial inquiries become more elaborate over time. Furthermore, there is a gradual resistance to the invited story format because it inhibits how the child organizes his stories. Volunteered stories obtain a more personal ‘voice’. The paper showcases the nexus between socialization and interactional competence.
KCNQ Channels Enable Reliable Presynaptic Spiking and Synaptic Transmission at High Frequency
Authors: Zhang Yihui , Li Dainan , Darwish Youad , Fu Xin , Trussell Laurence O. , Huang Hai 
Published: March 2022

The presynaptic action potential (AP) is required to drive calcium influx into nerve terminals, resulting in neurotransmitter release. Accordingly, the AP waveform is crucial in determining the timing and strength of synaptic transmission. The calyx of Held nerve terminals of rats of either sex showed minimum changes in AP waveform during high-frequency AP firing. We found that the stability of the calyceal AP waveform requires KCNQ (KV7) K+channel activation during high-frequency spiking activity. High-frequency presynaptic spikes gradually led to accumulation of KCNQ channels in open states which kept interspike membrane potential sufficiently negative to maintain Na+channel availability. Blocking KCNQ channels during stimulus trains led to inactivation of presynaptic Na+, and to a lesser extent KV1 channels, thereby reducing the AP amplitude and broadening AP duration. Moreover, blocking KCNQ channels disrupted the stable calcium influx and glutamate release required for reliable synaptic transmission at high frequency. Thus, while KCNQ channels are generally thought to prevent hyperactivity of neurons, we find that in axon terminals these channels function to facilitate reliable high-frequency synaptic signaling needed for sensory information processing.SIGNIFICANCE STATEMENTThe presynaptic spike results in calcium influx required for neurotransmitter release. For this reason, the spike waveform is crucial in determining the timing and strength of synaptic transmission. Auditory information is encoded by spikes phase locked to sound frequency at high rates. The calyx of Held nerve terminals in the auditory brainstem show minimum changes in spike waveform during high-frequency spike firing. We found that activation of KCNQ K+channel builds up during high-frequency firing and its activation helps to maintain a stable spike waveform and reliable synaptic transmission. While KCNQ channels are generally thought to prevent hyperexcitability of neurons, we find that in axon terminals these channels function to facilitate high-frequency synaptic signaling during auditory information processing.