bluuebunny/crossref_metadata_2025_split huggingface dataset:
Enhancing post traumatic growth during the COVID-19 lockdown: the roles of nature relatedness and perceived restorativeness
Authors: Zobel Sara Beomonte , Rogier Guyonne , Parolin Laura , Velotti Partrizia 
Published: February 2022

Abstract
Background
Although the negative outcomes related to traumatic events are well documented, people who experience traumatic events is able to manage the consequences in an adaptive way. This study aims to understand if perception of nature relatedness and perceived potential of restorativeness related to own house, explain Post-Traumatic Growth (PTG) in the context of a pandemic.
Methods
Through an online survey, disseminated during the national lockdown, we recruited 308 adults (Mage = 35.31; SD = 13.91; 22.7% males) administering them questionnaires to evaluate post-traumatic stress disorder (PTSD), PTG, perceived restorativeness and nature relatedness.
Results
Controlling for age and gender, we found that different facets of PTG were differently predicted by PTSD, Nature relatedness and perceived restorativeness. PTSD significantly predicted all dimension of PTG.
Conclusions
Perceived connection to nature as well as the sensation that own house is a place where one can escape from daily routine significantly predicted spiritual change and awareness of new possibilities in own life. Finally, fascination for the place where the individual lived significantly predicted spiritual change.
Implementing a complex hospital innovation: Conceptual underpinnings, program design and implementation of a Complex Innovation in an International Multi-Site Hospital Trial
Authors: Dryden-Palmer Karen , Berta Whitney B. , Parshuram Christopher S. 
Published: February 2022

Abstract
Background: Designing implementation programs that effectively integrate complex healthcare innovations is a fundamental aspect of knowledge translation. Good implementation design requires an active process. We describe a conceptually-grounded framework for the design of implementation programs for complex healthcare innovations and describe its implementation in pediatric hospital settings. Methods: We articulate the grounding implementation model and define overarching goals and principles of the implementation program design. Our Phased Reciprocal Implementation Synergy Model (PRISM) for implementation informed the articulation of the seven design principles: phased implementation approach, end-user engagement, responsive design, intentional integration with existing team processes, customizable implementation interventions, attendance to social mechanisms of influence, and inclusion of processes that support both learning and unlearning processes. These were then operationalized into implementation program, activities and innovation-specific tools. Results: The evidence informed and context responsive implementation program was applied to a complex, hospital wide implementation. Implementation interventions, education, communication and formative and summative evaluation tools were developed then customized for each participating hospital.Conclusion: Theoretically grounded and locally contexted implementation approaches are feasible for the adoption and integration of complex hospital wide innovations. Attention to the fitting of an innovation to local practices, the setting, organizational culture and end-user preferences can be achieved while maintaining the fidelity of the innovation.
Addressing caveats in current skate fisheries management: a comparative study on the morphometry and life history traits of commercially important skates blonde ray Raja brachyura and thornback ray Raja clavata.
Authors: Thys Kelly Johanna Marie , Lemey Laura , Bogaert Noémi Van 
Published: February 2022

Abstract
European skate fisheries management lacks species-specific measures due to data limitation and issues in species-specific reporting. Given these caveats, detailed information on commercially relevant skate stocks at species level is warranted. The morphometry and life-history parameters of 152 individuals (59 Raja brachyura, and 93 R. clavata) were determined for samples collected by observers within commercial fisheries, and two scientific surveys (December 2020 - August 2021) in the Southern North Sea and Eastern English Channel. The morphometry significantly differed between R. brachyura and R. clavata. Morphometric shape descriptor ratios were considered and proven more succesful in species discrimination than linear morphometric measurements. Length-weight relationships indicated faster growth for R. clavata. Age was assessed by visual inspection of enhanced vertebral centra, allowing derivation of von Bertalanffy growth parameters. The macroscopic maturity was determined, and the relationship between body size and sexual development was ascertained in maturity ogives following logistic regression. Maturity assessment revealed interspecific and intersexual differences where male R. clavata matured at the smallest size (L50 = 654 mm) and earliest age (A50 = 10.8 yrs) while female R. clavata matured at the largest size (L50 = 839 mm) and latest age (A50 = 11.5 yrs). The morphometry of congeners R. clavata and R. brachyura significantly differs, which is reflected in the life history traits: length-weight relationships, growth, and reproductive biology. These interspecific differences once again highlight the need for species-specific data collection and management considerations of commercially relevant skate stocks in the Northeast Atlantic Region.
Lessons Learned From a Failed Implementation: Effective Communication with Patients in Transmission-Based Precautions
Authors: Juskevicius Luize Fábrega , Luz Reginaldo Adalberto , Felix Adriana Maria da Silva , Timmons Stephen , Padoveze Maria Clara 
Published: February 2022

Abstract
Background
Patient education and engagement about standard and transmission-based precautions can be one important strategy to prevent adverse events related to isolation. However, most patient education is still highly prescriptive, and is thus unlikely to help patients to engage in their own care. Implementing effective communication between health workers and patients requires behavior change, leading to a meaningful dialogue between the parties involved in the education process.
Objective
this study aimed to evaluate the process of implementation of a protocol for effective communication with patients in transmission-based precautions (Com-Efe).
Methods
This is implementation researchusing qualitative methods, carried out in four sequential phases: 1) non-participant observation in inpatient wards, with the objective of assessing the context; 2) designing the intervention for the implementation of the protocol Com-Efe, based on the results obtained in the previous phase; 3) preliminary assessment and adaptation of the Com-Efe protocol, through workshops with nurses; 4) final assessment of the implementation results, through semi-structured interviews with nurses. The study was performed in a public, secondary level, teaching hospital. The Consolidated Framework for Implementation Research (CFIR) was used as the reference for both interview design and data analysis, aiming to identify barriers and enablers of the implementation process.
Results
The main factors that could have facilitated adherence were beliefs and perceived advantages in using the Com-Efe. The main barriers which may have contributed to the failure of implementation were the unfavorable climate for implementation, insufficient individual and leadership commitment, and lack of understanding of the concepts underpinning effective communication. The participants recognized they had low adherence to the Com-Efe protocol.
Conclusions
Despite using a systematic approach, the Com-Efe protocol was not fully implemented. The lessons learned in this study allowed us to propose suggestions for future implementations in similar contexts. Among these suggestions are to develop strategies to generate awareness of patient-centered care, maintaining patient autonomy, and seeking dialog for patient engagement.
Establishing The Taxa With Phylogenetic Profile And In-Silico-Ayurvedic Remedy Of Microbiome Of Bacterial Vaginosis
Authors: Bagchi Preenon , S Geethashree , IA Shylesh Murthy 
Published: February 2022

Abstract
Bacterial vaginosis (BV) is a vaginal disease commonly caused by bacteria which most commonly causes abnormal vaginal discharge during women’s reproductive-age. BV is characterized by a shift within the vaginal flora from the dominant Lactobacillus to a polymicrobial flora and is further characterized by depletion of the resident lactic-acid-producing Lactobacillus spp. BV has been associated with serious health issues, including pelvic inflammatory disease and increased susceptibility to sexually transmitted diseases (STD) but itself is not a STD. Several genes and chromosomal regions have been found to be associated with BV in various linkage analyses, case-control studies, genome-wide association studies (GWAS), and admixture mapping studies.In this work, using BV microbiome we perform metagenome analysis which enables us to understand how the microbiome responds to the host by studying the functional analysis of genes expressed. The technology is used to determine the order of nucleotides or targeted regions of DNA or RNA. Krona pie chart is used for visualization of the taxonomy. HUMAnN2 tool is used to determine the pathways and their abundance file of microbiome. Further, homology modelling of the BV gene receptors, Leucine Aminopeptidase 3 (LAP3) and Peptidase D (PEPD) was done and ligands from ayurvedic medicinal herbs were established
Errors In Pediatric Death Certificates Issued By Emergency Departments
Authors: Park Byeong Ju , Kim Sun Hyu 
Published: February 2022

Abstract
Background: Errors in pediatric death certificates (DCs) are rarely reported. We analyzed the errors in the pediatric DC issued by an emergency department (ED).Methods: The DCs issued at the ED to patients below the age of 18 years were retrospectively analyzed. Major and minor errors in the DC were investigated based on the WHO International Statistical Classification of Diseases and Related Health Problems (ICD-10) guidelines and evaluated based on the review of the medical records by four emergency physicians. Manner of death was classified into disease (disease group) and external causes (external group) and that two groups were compared. Results: Among the 87 cases of DCs issued by the ED, 98% of errors were confirmed in the disease group and 100% in the external group. The total number of errors in the analyzed DC was 2.3 in the disease group and 3.3 in the external group. Blank space in the cause of death (COD) or duplicated COD (18%) were most common major error in the disease group and two or more causes in a single line of COD (36%) in the external group. Among minor errors, the cases without a time interval record for the COD were the most common in 37 cases (93%) and 42 cases (89%) of the two groups, respectively.Conclusion: One or more errors were identified in 99% of pediatric DCs issued by ED, and the total number of errors was higher in the external group than in the disease group.Trial registration: none
Anti-SARS-Cov-2 Iga And Igg In Human Milk From Vaccinated Mothers After Holder Pasteurization.
Authors: Selma-Royo Marta , Gormaz María , Bäuerl Christine , Ramón-Beltrán Amparo , Cernada Maria , Esteban Maria Jesús Vayá , Martinez-Rodriguez Laura , Vento Máximo , Parra-Llorca Anna 
Published: February 2022

Abstract
Breastfeeding rendered crucial for preterm infants during COVID-19 pandemic. However, the role of donated human milk (DHM) in the protection against SARS-CoV-2 infection when own mother’s milk is not available or insufficient remains unclear. Pasteurization of DHM contributes to the loss of some biological and nutritional properties of human milk. The presence of specific breast milk SARS-CoV-2 antibodies has been demonstrated in women after COVID-19 disease and after vaccination. We aimed to evaluate the impact of Holder pasteurization on vaccinated donor women’s milk and to identify the impact on the concentrations of specific immunoglobulins (Ig) against SARS-CoV-2. A prospective, observational, exploratory pilot study in lactating women (n=12) who received the complete course of mRNA-based vaccines (BioNTech/Pfizer) against SARS-CoV-2 infection was conducted. Levels of antibodies directed to structural receptor-binding domain of the SARS-CoV-2 spike protein were determined by ELISA before and after pasteurization.IgA and IgG anti-SARS-CoV-2 immunoglobulin concentrations were significantly reduced after Holder pasteurization. Interestingly, there was a negative correlation between the initial amount of anti-SARS-CoV-2 antibodies and the percentage of their recovery after the pasteurization for both isotypes. Despite the partial loss of immunoglobulins still a high percentage of antibodies remained after the pasteurization, a mean of 70.53 (3.4)% of anti-SARS-CoV-2 IgA and 81.99 (21.89)% of IgG antibodies. Our study underscores the potential relevance of breast feeding or alternatively DHM to provide babies at risk with virus-specific SARS-CoV-2 antibodies thus protecting them against COVID-19.
Retinal Ganglion Cell Layer Thickness And Volume Measured By Optical Coherence Tomography Changes With Age, Sex, And Axial Length In A Healthy Population
Authors: Al-Hawasi Abbas , Lagali Neil 
Published: February 2022

Abstract
Background: The GCL measurements with OCT are important for both ophthalmologists and neurologist because of the association with many ophthalmic and neurological diseases. Different factors can affect these measurements, as brain pathologies, ocular AL as well as age and sex. Studies that conducted to measure GCL have overlooked many of these factors. The purpose of this study is to examine the effect of age, sex, and axial length on normal retinal GCL thickness and volume in a healthy population without any neurological diseases.Methods: A prospective cross-sectional study to measure the retinal (GCL) thickness and total volume with optical coherence tomography (OCT) with automated segmentation and manual correction where needed. Visual acuity, axial length, and autorefraction were also measured. A mixed linear model was used to determine the association of the effect of the various parameters on the GCL thickness and volume.Results: 116 eyes of 60 subjects (12-76 years of age, 55% female) were examined of which 77% had 0 ± 2 D of spherical equivalent, and mean axial length was 23.86 mm. About 25% of the OCT-automated GCL measurements required manual correction. GCL thickness did not differ in similar anatomic regions in right and left eyes (P > 0.05). GCL volume was greater in males relative to females after adjustment for age and axial length (1.13 ± 0.07 mm3 for male vs 1.09 ± 0.09 mm3 for females; P = 0.031). GCL thickness differed between males and females in the inner retinal ring (P=0.025) but not in the outer ring (P=0.66). GCL volume declined with age (P=0.031) but not after adjustment for sex and axial length (P=0.138). GCL volume declined with longer axial length after adjustment for age and sex (P=0.048). Conclusion: Age, sex and axial length should be taken into consideration when measuring the GCL thickness and volume with OCT. Automated OCT segmentation should be reviewed for manual adjustments.
Correlated Expression of The Body, Face, and Voice During Character Portrayal in Actors
Authors: Berry Matthew , Lewin Sarah , Brown Steven 
Published: February 2022

Abstract
Actors are required to engage in multimodal modulations of their body, face, and voice in order to create a holistic portrayal of a character during performance. We present here the first trimodal analysis of the process of character portrayal in professional actors. The actors portrayed a series of stock characters (e.g., king, bully) that were organized according to a predictive scheme based on the two orthogonal personality dimensions of assertiveness and cooperativeness. We used 3D motion capture technology to analyze the relative expansion/contraction of 6 body segments across the head, torso, arms, and hands. We compared this with previous results for these portrayals for 4 segments of facial expression and the vocal parameters of pitch and loudness. The results demonstrated significant cross-modal correlations for character assertiveness (but not cooperativeness), as manifested collectively in a straightening of the head and torso, expansion of the arms and hands, lowering of the jaw, and a rise in vocal pitch and loudness. These results demonstrate what communication theorists refer to as “multichannel reinforcement”. We discuss this reinforcement in light of both acting theories and theories of human communication more generally.
Prevalence of Childhood Cataract and Associated Factors Among a Pediatric Population at A Tertiary Hospital in Ghana
Authors: Amankwaa-Frempong Doreen , Atia Kelvin , Kumah David Ben , Junior Isaiah Osei Duah , Addo Emmanuel Kofi , Ahmed Abdul-Sadik , Akuffo Kwadwo Owusu 
Published: February 2022

Abstract
Background: Childhood cataract unlike adult-related cataract has received a little attention despite the devastating consequences on the early development of the visual system and the overall impact on the quality of life of children. The existence of accurate epidemiological data is a primary step towards management strategies, however, there remains a paucity of data in sub-Saharan Africa including Ghana. Therefore, the study sought to investigate the prevalence of childhood cataract and its associated factors among a pediatric population at a tertiary health facility in Ghana. Methods: The study employed a retrospective electronic medical-record review on 263 pediatric cataract cases examined (from January 2019 to December 2020) at the pediatric ophthalmology department of the Komfo Anokye Teaching Hospital, Kumasi, Ghana. Patient clinical data including sociodemographic, signs and symptoms, primary diagnosis and associated ocular complications were gathered and analyzed using Statistical package and Service Solution (SPSS). Chi-square and regression statistics were used to summarize data at a significance of p< 0.05. Results: The prevalence of childhood cataract was 4.25% (263/6,188). The proportionate distribution of cataracts was congenital (39.5%), traumatic (33.1%) and developmental (26.6%). Over half (51.7%) of the subjects had unilateral cataract. The major complications of childhood cataracts were strabismus (5.70%), nystagmus (3.0%) and retinal detachment (1.90%). Older age (2-12 years, OR = 0.27, p<0.001; > 12 years, OR = 0.12, p<0.001) was significantly associated with reduced odds of congenital cataract. Similarly, increasing age (2-12 years, OR = 12.59, p<0.001; > 12 years, OR = 7.57, p = 0.004) and female sex (OR = 0.58, p = 0.038) was significantly associated with decreased odds of traumatic cataracts. Conversely, older age (2-12 years, OR = 11.02, p<0.001; > 12 years, OR = 26.57, p<0.001) and female sex (OR = 2.27, p = 0.008) were significantly associated with increased odds of developmental cataracts. Conclusion: Our results suggest a higher burden of childhood cataract (approximately four in every hundred children had childhood cataract). This evidence warrants the implementation of pre-school vision screening and eye health education programmes to promote early detection and prevention of avoidable vision impairment and/or blindness within the pediatric population.
Factors influencing parental decisions to terminate pregnancies following prenatal diagnoses of major fetal anomalies at a single university hospital in Thailand
Authors: Pusayapaibul Papapin , Manonai Jittima , Tangshewinsirikul Chayada 
Published: February 2022

Abstract
Background: The rate of termination of pregnancy (TOP) for fetal anomalies and the factors affecting TOP vary among different populations. Optimisation of prenatal care and counselling requires understanding the factors influencing parental decisions in the relevant population. This study aimed to evaluate the rate of TOP after diagnoses of major fetal anomalies and assess factors associated with TOP-related decisions at a university hospital in Thailand.Methods: A retrospective chart review was conducted at the Fetal Anomaly Clinic of the university hospital in Thailand. Medical records of all women with singleton pregnancies prenatally diagnosed with major fetal anomalies before 24 gestational weeks between 2010 and 2020 were reviewed.Results: During the study period, 461 cases of major fetal anomalies were diagnosed, and 264 (57.3%) of these pregnancies were terminated. Three factors influencing parental TOP decisions were lethal anomalies (odds ratio [OR], 177.41; 95% confidence interval [CI], 46.97–670.15; p <0.001), presence of genetic abnormalities (OR, 11.93; 95% CI, 4.93–28.91; p <0.001) and an early gestational age of <20 weeks (OR, 3.81; 95% CI, 2.01–7.22; p <0.001).Conclusions: Over half of the pregnant women whose records were reviewed and who were prenatally diagnosed with major fetal anomalies terminated their pregnancies. Fetal factors, particularly lethality, genetic abnormalities and early gestational age at diagnosis, showed the most powerful associations with parental TOP decisions. Other maternal background factors were not key considerations.
The Retrospective Evaluation Of Endocrine Manifestations In Chinese Patients With Wilson’s Disease
Authors: Zhang Mei-Yan , Zheng Zi-Wei , Shi Zhi-Feng , Xu Meng-Hui , Wang Rou-Min , Xu Wan-Qing , Wu Zhi-Ying , Dong Yi 
Published: February 2022

Abstract
Purpose: The endocrine manifestations of Wilson’s disease (WD) tended to be ignored, especially as initial clinical aspects. Currently there was a paucity of studies for endocrine involvement in WD patients. We aim to explore the explicit impact of WD on the endocrine system, to reduce the misdiagnosis.Methods: A retrospective study was performed in 37 female patients with WD. They were recruited from the Second Affiliated Hospital of Zhejiang University School of Medicine from October 2018 to October 2020. Each patient was diagnosed with WD according to clinical evaluation and genetic test. Their menstrual, pregnancy and childbirth history, and sex hormone levels were collected and analyzed.Results: The average age of menarche was 13.7 ± 2.0 years. The proportion of delayed menarche was 37.8%. The patients with irregular menstruation after menarche accounted for 50%. Among 65 conceptions of 37 WD patients, the spontaneous abortion, induced abortion, preterm birth, and full-term delivery rate was 46.2%, 27.7%, 12.3% and 13.8% respectively. The abnormal hormone levels of the 35 cases mainly consisted of 14 cases (40%) with increased PRL, 10 cases with decreased P (28.6%), 8 cases (22.9%) with increased SHBG and 6 cases (17.1%) with increased T.Conclusion: The endocrinologic manifestations among WD patients could be not uncommon. WD patients could manifest as irregular menstruation, recurrent abortion, and even infertility. These minor aspects as a presenting feature of WD are prone to be neglected. Therefore, WD should be encountered in the differential diagnosis of endocrine system dysfunction.