bluuebunny/crossref_metadata_2025_split huggingface dataset:
Diagnostic Accuracy of Preoperative CT and Endoscopy Staging in Early Laryngeal Cancer
Authors: Stevanović Siniša , Gregurić Tomislav , Pažanin Leo , Ivkić Boris , Geber Antonela , Hadžavdić Ayla , Košec Andro 
Published: June 2022

AbstractObjectivesThis study aims to evaluate the diagnostic accuracy of preoperative computed tomography (CT) and intraoperative endoscopic tumor staging with regard to histopathologic staging in patients with early laryngeal cancer.Study DesignA retrospective nonrandomized single‐institution comparative cohort study including 109 patients.SettingA tertiary surgical center.MethodsPatients were treated for T1a, T1b, and T2a laryngeal squamous cell carcinoma by endoscopic laser surgery. The outcome measures were the presence of under‐ or overstaging in endoscopic and CT findings and positive postoperative margins.ResultsEndoscopic overstaging as compared with histopathologic T category correlated with rising tumor category (P = .001; odds ratio [OR], 69.1) and CT findings showing anterior commissure involvement (P = .002; OR, 9.54), while endoscopic understaging correlated with rising tumor histologic grade (P = .039; OR, 4.28) and smaller tumor size (P = .011; OR, 6.39). CT overstaging vs histopathologic T category correlated with CT findings showing anterior commissure involvement (P = .001; OR, 21.76), supraglottic involvement (P = .001; OR, 59.98), subglottic involvement (P = .001; OR, 39.94), rising clinical T category (P = .01; OR, 9.11), and rising tumor histologic grade (P = .004; OR, 10.95). CT understaging as compared with histopathologic T category correlated with smaller clinical T categories (P = .002; OR, 12.72) and smaller tumor histologic grade (P = .030; OR, 7.02). Rising age, rising tumor size, anterior commissure involvement on CT, and tumor extension into the supraglottis were risk factors for positive margins.ConclusionOur results indicate that CT adds little valuable information in differentiating small superficial lesions in the glottis, while systematically overstaging cases of early laryngeal cancer. In T1a and T1b glottic tumors, endoscopy should be the preferred diagnostic method.
The Most Common Type, Severity, and Expected Frequency of Injuries Vary by Defensive Position in Professional Baseball Players
Authors: Carr James B. , McElheny Kathryn D. , Corrigan Anne , Rowe Dana , Ma Kevin , Curriero Frank C. 
Published: June 2022

Background: Location, frequency, and severity of in-game injuries by defensive position played have never been determined in professional baseball players. Hypothesis: Catchers would have a higher frequency of hip and knee injuries; infielders and outfielders would have a higher frequency of general lower extremity injuries; and pitchers would have a higher frequency and severity of shoulder and elbow/forearm injuries. Study Design: Descriptive epidemiology study. Methods: The Major League Baseball Health and Injury Tracking System database was queried for all injuries in Major League Baseball and Minor League Baseball during the 2011-2019 seasons. Injuries were stratified by the following variables: athlete’s level of play at the time of injury, anatomic region injured, whether the injury occurred during a game, and position played at the time of injury (infielder, outfielder, catcher, or pitcher). Number of days missed from competition immediately after an injury was used as a surrogate for injury severity: mild (0 days missed), moderate (1-5 days), and severe (>5 days). Observed versus expected injury ratios were calculated for each anatomic region based on position played, and ratios were adjusted by the number of players per position type during a standard inning of play. Results: A total of 112,405 work-related injuries were reported, with the majority of injuries (86,520; 77%) occurring in Minor League Baseball athletes. Injuries to the leg, hand, shoulder, torso, and foot were the most common for athletes in both leagues, while hip/groin injuries were the least common. Catchers sustained the most in-game defensive head/neck injuries, while infielders and outfielders had the highest number of knee injuries. Starting and relief pitchers had the greatest total proportion of in-game defensive injuries across every other body region. Infielders and outfielders sustained injuries less frequently than expected across all body regions, while pitchers experienced more injuries than expected for all body parts. Catchers experienced more injuries than expected to the head/neck, hand, hip/groin, knee, and foot, and were more likely than other position players to sustain a knee injury that was categorized as severe based on time missed. Conclusion: The location, severity, and frequency of injuries vary by defensive position among professional baseball players.
The effects of solvents on the physical and electrochemical properties of potassium-ion conducting polymer gel electrolytes
Authors: Madhani Vaishali , Rathore Mahendra Singh , Kumar Deepak 
Published: June 2022

The aim of present work is to investigate the effect of different solvent mixed within poly (vinylidiene fluoride-hexafluoropropylene) (PVDF-HFP) based Potassium ion conducting polymer gel electrolytes. The samples are prepared using solution casting method and the comparative behavior of adding carbonate and glyme in PVDF-HFP/KClO4 matrix is investigated. Subsequently, polymer gel electrolytes are characterized using X-ray diffractometer to analyze the structural features of the electrolyte films. The XRD results reveal that the prepared electrolyte films using both solvents demonstrate semi-crystalline nature. The surface morphology is studied using scanning electron microscopy and significant changes in surface morphology of the polymer gel electrolyte films is observed on introducing carbonate and glyme solvents. Thermal properties and effects of temperature on the prepared electrolytes is examined using differential scanning calorimetry and investigations reveal significant effect of temperature on the heat flow into the polymer gel electrolytes samples. The weight loss of the electrolyte samples with temperature is studied using Thermogravimetric analysis and it is observed that carbonate and glyme based electrolyte offer weight loss of about 7–8 %. The ionic conductivity of 2.53×10−7 Scm−1 and 3.67×10−4 Scm−1 while electrochemical stability window of ∼2.5 V is obtained for both polymer gel electrolytes with carbonate and glyme based solvents. The reversibility of K-ion has been established using cyclic voltammetry measurements.
Dignity in fragile older women receiving daily municipality care
Authors: Kaldestad Kari , Nåden Dagfinn 
Published: June 2022

Background:Dignity is an important ideal in the nursing of older women who need municipal care. Dignity can be challenged when health is impaired by feeling grief and suffering associated with bodily changes and impaired functions. Aim and research questions:The study aimed to deepen the understanding of the meaning of dignity in the life of fragile older women who daily needed help from municipal care service. The research questions are: What is older women’s experience of dignity, and what is it not to be met with dignity when needing service from municipality care? Research design: The study has a qualitative design, and the methodology is based on Gadamer’s ontological hermeneutics. Ten women receiving municipal care, aged from 66 to 91 were interviewed in their home environments. Kvale and Brinkmanns’ three levels of interpretation were applied in the analysis of the interviews: self-understanding, a critical understanding based on common sense, and theoretical understanding. Ethical considerations: The study follows the guidelines for good scientific practice according to the Declaration of Helsinki and was approved by the Norwegian Centre for Research Data. Results: The interviews revealed fragments of the women’s unique life history. Two themes emerged from the interpretation: Confirming encounters provide human dignity; and Not being confirmed as a human being violates human dignity. Conclusions:For the women, dignity is about feeling seen and understood by the individual nurse and this takes place both in conversation and in bodily care. Not being seen or confirmed gives rise to suffering. The reason for this seems to be lack of competence on the part of the staff or little continuity.
Evaluation of a pet-separating automatic feeder and high-frequency meal feeding for weight loss in multi-cat households
Authors: Witzel-Rollins Angela , Murphy Maryanne , Springer Cary M , Moyers Tamberlyn D , Albright Julia D 
Published: June 2022

Objectives The objectives of this study were two-fold: (1) to determine if a feeder system providing individualized food access and automatic dispensing of meals makes weight-loss programs in multi-cat homes easier for cat owners; and (2) to assess if feeding six meals daily reduces food-seeking behavior and increases calorie requirements vs two meals per day. Methods Adult cats with body condition scores (BCSs) of 7/9 or greater underwent a weight-loss plan for up to 6 months using a traditional feeding bowl with two meals per day (B2) or an automatic feeder with two meals (A2) or six meals (A6) per day. Cats were weighed at weeks 0, 2, 4, 6, 10, 14, 18, 22 and 26 and food intake was adjusted to maintain weight-loss rates between 0.5% and 1.5% body weight per week. Owner questionnaires were completed at each study visit. Results Twenty-three cats were included in the study. Cats fed from the automatic feeders were more likely to reach ideal body condition ( P = 0.006), with 83.2% of cats in A6, 40% of cats in A2 and no cats in B2 achieving a BCS of ⩽6/9. Owners of cats fed from automatic feeders reported the weight-loss plan was easier vs owners of cats fed from bowls ( P = 0.01). Owners using the automatic feeders also reported fewer incidences of certain food-seeking behaviors. Neither percent body weight lost per week nor calorie intake per kg differed between groups. Conclusions and relevance Feeding six instead of two meals daily did not result in faster rates of weight loss or the need to increase calorie intake to maintain appropriate rates of weight loss. However, use of an automatic feeder that provided separated, portioned meal feeding made the weight-loss program easier, reduced food-seeking behaviors and improved the overall success of the weight-loss plan.
Ear-tipping practices for identification of cats sterilized in trap–neuter–return programs in the USA
Authors: Dalrymple Aimee M , MacDonald Lauren J , Kreisler Rachael E 
Published: June 2022

Objectives Ear-tipping practices and the meaning of the ear tip in trap–neuter–return (TNR) programs have not been well documented. The purpose of this study was to report the frequency of common ear-tipping practices in the USA, to identify the most effective methods and to establish a foundation for ear-tipping practice standards. Methods An anonymous 24-question survey was advertised from 4 to 20 October 2021 to individuals who participate in TNR programs that routinely perform ear tipping. Results There were 526 survey responses from individuals who participate in TNR programs, of whom 410 completed the survey. For ear-tip meaning, nearly 100% of respondents indicated that an ear tip meant that a cat had been sterilized. Several respondents answered that it also indicated rabies vaccination or socialization status, with 92 (22%) selecting both, 79 (19%) selecting rabies only and 50 (12%) selecting unsocial only. The majority of respondents tipped the left ear (81%), used a visual estimate to determine the cut (92%) and described the ideal silhouette as straight across (92%). The median percentage of cats where ear tips bled after initial hemostasis was 5% (interquartile range [IQR] 2–10), and the median percentage of negative feedback regarding the ear tip was 1% (IQR 0–5). In terms of weighted rank order, the most common feedback was that too much ear tip was removed (5.5), followed by a cat being ear tipped in error (4.7), persistent bleeding (4.2) and not enough ear tip being removed (4.2). Responses revealed heterogeneity regarding technique for both excision and hemostasis, as well as personnel performing the procedure. There were no significant associations between techniques and bleeding or negative feedback. Conclusions and relevance There is variation in the methods for performing an ear tip, as well as what an ear tip signifies. Standards for this procedure would be helpful.
Feline non-erosive immune-mediated polyarthritis: a multicentre, retrospective study of 20 cases (2009–2020)
Authors: Wootton Florence , Glanemann Barbara , Langley-Hobbs Sorrel , Breheny Craig , Fowlie Samuel , Whitworth Fiona , Silvestrini Paolo , Threlfall Anna , Sorrell Stephanie , Black Vicki 
Published: June 2022

Case series summary Cats with non-erosive immune-mediated polyarthritis (IMPA) were identified from seven referral hospitals between 2009 and 2020 for a multicentre retrospective case series. Data were obtained from hospital records and referring veterinarians were contacted for follow-up. Twenty cases were identified: 12 castrated males (60%), one entire male (5%) and seven spayed females (35%). Common clinical signs included lameness (n = 20/20) and pyrexia (n = 10/18). Three cats presented with and two cats developed ligament laxity during treatment. Thirteen cats (65%) were diagnosed with non-associative IMPA and seven (35%) with associative IMPA. Comorbidities identified included chronic enteropathy (n = 3/7), feline immunodeficiency virus (n = 1/7), feline herpesvirus (n = 1/7), bronchopneumonia (n = 1/7) and discospondylitis (n = 1/7). Sampling of the tarsal joints most frequently identified an increased proportion of neutrophils, consistent with IMPA. Eighteen cats (90%) received immunosuppressants. Eleven cats were started on prednisolone; eight had a poor response resulting in the addition of a second agent, euthanasia or acceptance of the persisting signs. One cat received ciclosporin and required an alternative second agent owing to adverse effects. Five cats were started on prednisolone and ciclosporin; three had a poor response and required an alternative second agent. One cat received prednisolone and chlorambucil and had a good response. Two cats (10%) received meloxicam and had a good response, although the clinical signs recurred when medication was tapered. A good outcome was achieved in 14/20 cats (70%) with IMPA. In the cats with a poor outcome 4/6 were euthanased and 2/6 had chronic lameness. Relevance and novel information Prognosis for feline IMPA can be good. Multimodal immunosuppression was often required. IMPA should be considered in lame cats, with or without pyrexia, when there is no evidence of trauma or infection. The tarsal joints should be included in the multiple joints chosen for sampling. Ligament laxity can occur in non-erosive feline IMPA.
Exploring the contemporary Moon Under Water through illustration: nostalgia and the power of the image
Authors: Black Stephanie 
Published: June 2022

This article uses images from the visual essays produced for Plume of Feathers, an audio-visual project, to examine the notion of ‘reflective nostalgia’ as an attitude towards meaning-making within image creation, in particular illustration that can counter certain political uses of images that present a restorative–nostalgic world view. The project at the core of the article is concerned with the decline of public houses and their social function in the UK. However, the image of the pub is embroiled within the visual rhetoric related to the UK’s (2016) Brexit referendum. This article explores the ways in which the illustrated image can provide a different view of the pub that reveals the conceptual construction of the notion of ‘pub’ and offers a critical alternative. The constructed nature of the illustrated image is then explored for its potential to visualize the past differently, following Svetlana Boym’s proposal of reflective nostalgia in The Future of Nostalgia (2001) in order to address problems in the present. The article proposes that reflective nostalgia’s utility as a critical tool lies in its consideration of the key role played by the surface of the image, through the material signifiers of age. As illustrators, embracing these nostalgic triggers when making images allows the viewer to reconnect to the past with critical distance, thereby returning politics to the surface of the image, something that Fredric Jameson saw in Postmodernism, Or the Cultural Logic of Late Capitalism (1991) as recuperated and rendered politically neutral. Illustration is therefore cast as a meaning-making practice that shapes the world it operates within, with the article suggesting that by making nostalgic images, illustrators can exercise their agency as agitators.
The prevalence of Implanon discontinuation and associated factors among Ethiopian women: A systematic review and meta-analysis
Authors: Habte Aklilu , Tamene Aiggan , Woldeyohannes Demelash , Bogale Biruk , Ermias Dejene , Endale Fitsum , Gizachew Addisalem , Wondimu Merertu , Sulamo Dawit 
Published: June 2022

Background: Implanon discontinuation before the recommended time is problematic, as it puts women at risk of unwanted pregnancies and unsafe abortions, along with negative maternal health outcomes. Although the magnitude and determinants of Implanon discontinuation have been studied in Ethiopia, the results were inconsistent, with significant variability. Hence, this systematic review and meta-analysis aimed at estimating the pooled prevalence of Implanon discontinuation and its determinants in Ethiopia. Methods: A comprehensive search of studies published before 18 February 2022 was done using electronic databases such as PubMed, Embase, Google Scholar, Scopus, Web of Science, Science Direct, and Cochrane Library. The relevant data were extracted using a Microsoft Excel 2013 and analyzed using STATA Version 16. A random-effect meta-analysis model was used to compute pooled prevalence and odds ratio. The Cochrane Q test statistics and I2 tests were used to assess the heterogeneity of the included studies. A funnel plot, Begg’s, and Egger’s tests were used to check for the presence of publication bias. Results: A total of 11 studies with 4320 study participants were included in this meta-analysis. The overall pooled prevalence of Implanon discontinuation in Ethiopia was found to be 32.62% (95% confidence interval = 24.10, 41.13). There was significant heterogeneity among the included studies ( I2 = 97.4%, p < 0.001). However, there was no statistical evidence of publication bias ( p = 0.533). Dissatisfied with service provision at the time of insertion (odds ratio = 3.92, 95% confidence interval = 1.54, 6.29), not having pre-insertion counseling (odds ratio = 2.98, 95% confidence interval = 1.91, 5.04), the absence of post-insertion follow-up (odds ratio = 4.03, 95% confidence interval = 2.17, 5.90), and the presence of side effects (odds ratio = 2.93, 95% confidence interval = 1.87, 3.98) were found to be determinants of Implanon discontinuation. Conclusion: According to this systematic review and meta-analysis, one-third of Ethiopian women discontinued Implanon before the recommended time (3 years). Program managers and service providers should consider using more evidence-based and participatory counseling approaches to enhance client satisfaction. Furthermore, family planning service delivery points should be equipped to manage and reassure women who are experiencing side effects.
Evolving landscape of first-line combination therapy in advanced renal cancer: a systematic review
Authors: Lalani Aly-Khan A. , Heng Daniel Y. C. , Basappa Naveen S. , Wood Lori , Iqbal Nayyer , McLeod Deanna , Soulières Denis , Kollmannsberger Christian 
Published: June 2022

Background: Renal cell carcinoma (RCC) is a common malignancy with approximately 30% of cases diagnosed at the advanced or metastatic stage. While single-agent vascular endothelial growth factor-targeted therapy has been a mainstay of treatment, data from multiple phase III trials assessing first-line immune checkpoint inhibitor (ICI) combinations have demonstrated a significant survival benefit. Methods: A systematic search of the published and presented literature was performed to identify phase III trials assessing ICI combination regimens in RCC using search terms ‘immune checkpoint inhibitors’ AND ‘renal cell carcinoma,’ AND ‘advanced’. Results: Six phase III trials showed significant benefits for ICI combinations compared with sunitinib. Nivolumab plus ipilimumab significantly improved overall survival [OS; median, 47.0 versus 26.6 months, hazard ratio (HR) = 0.68, 95% confidence interval (CI) = 0.58–0.81, p < 0.0001) and progression-free survival (PFS; median 11.6 versus 8.3 months, HR = 0.73, 95% CI = 0.61–0.87, p = 0.0004) in International Metastatic renal cell carcinoma Database Consortium intermediate and poor-risk patients. OS was also significantly improved for ICI plus tyrosine kinase inhibitor combinations regardless of risk, including pembrolizumab plus either axitinib (HR = 0.73, 95% CI = 0.60–0.88, p < 0.001) or lenvatinib (HR = 0.66, 95% CI = 0.49–0.88, p = 0.005) and nivolumab plus cabozantinib (HR = 0.66, 95% CI = 0.50–0.87, p = 0.003). No new safety signals were identified. Conclusions: Phase III first-line trials of ICI combinations showed survival benefits compared with a control arm of sunitinib. Global access to these combinations should be made available to patients with advanced RCC.
A Minority of Athletes Pass Symmetry Criteria in a Series of Hop and Strength Tests Irrespective of Having an ACL Reconstructed Knee or Being Noninjured
Authors: Markström Jonas L. , Naili Josefine E. , Häger Charlotte K. 
Published: June 2022

Background: Between-leg symmetry in 1-leg hop and knee strength performances is considered important after anterior cruciate ligament reconstruction (ACLR) to facilitate a safer return to sport. While few athletes with ACLR demonstrate symmetry in test batteries, reference data for noninjured athletes are lacking, thus questioning how ACLR-specific poor symmetry is. Hypothesis: Athletes with ACLR (hamstring autograft) show lower symmetry and have a lower proportion of symmetric individuals than noninjured athletes for knee flexion strength but not for hop for distance, vertical hop, and knee extension strength. Study design: Cross-sectional. Level of Evidence: Level 3. Methods: A total of 47 athletes with ACLR (median 13.0 months post-ACLR) who had returned to their sport, and 46 noninjured athletes participated. Symmetry was calculated between the worse and better legs for each test and combinations of them using the limb symmetry index (LSIWORSE-BETTER, ranging from 0% to 100%). The 2 groups were compared for these values and the proportions of individuals classified as symmetric (LSIWORSE-BETTER ≥90%) using independent t-tests and Fisher’s exact tests, respectively. Results: Athletes with ACLR were less symmetric than noninjured athletes for knee flexion strength with a lower LSIWORSE-BETTER (83% vs 91%, P < 0.01) and a lower proportion of symmetric individuals (39% vs 63%, P = 0.04). No differences between groups were revealed for the hop tests, knee extension strength, or combinations of tests ( P > 0.05). Only 17% of the athletes with ACLR and 24% of the noninjured athletes demonstrated symmetric performances for all 4 tests. Conclusion: Athletes with ACLR (hamstring autograft) showed poorer symmetry in knee flexion strength than noninjured athletes, although both groups had few individuals who passed the test battery’s symmetry criteria. Clinical relevance: Symmetry is uncommon among athletes irrespective of ACLR and should be considered regarding expected rehabilitation outcomes and return-to-sport decisions post-ACLR.