bluuebunny/crossref_metadata_2025_split huggingface dataset:
Providing laypeople with results from dynamic infectious disease modelling studies affects their allocation preference for scarce medical resources—a factorial experiment
Authors: Rübsamen Nicole , Garcia Voges Benno , Castell Stefanie , Klett-Tammen Carolina Judith , Oppliger Jérôme , Krütli Pius , Smieszek Timo , Mikolajczyk Rafael , Karch André 
Published: March 2022

Abstract
Background
Allocation of scarce medical resources can be based on different principles. It has not yet been investigated which allocation schemes are preferred by medical laypeople in a particular situation of medical scarcity like an emerging infectious disease and how the choices are affected by providing information about expected population-level effects of the allocation scheme based on modelling studies. We investigated the potential benefit of strategic communication of infectious disease modelling results.

Methods
In a two-way factorial experiment (n = 878 participants), we investigated if prognosis of the disease or information about expected effects on mortality at population-level (based on dynamic infectious disease modelling studies) influenced the choice of preferred allocation schemes for prevention and treatment of an unspecified sexually transmitted infection. A qualitative analysis of the reasons for choosing specific allocation schemes supplements our results.

Results
Presence of the factor “information about the population-level effects of the allocation scheme” substantially increased the probability of choosing a resource allocation system that minimized overall harm among the population, while prognosis did not affect allocation choices. The main reasons for choosing an allocation scheme differed among schemes, but did not differ among those who received additional model-based information on expected population-level effects and those who did not.

Conclusions
Providing information on the expected population-level effects from dynamic infectious disease modelling studies resulted in a substantially different choice of allocation schemes. This finding supports the importance of incorporating model-based information in decision-making processes and communication strategies.
Does musculoskeletal pain interfere with motor learning in a gait adaptation task? A proof-of-concept study
Authors: Dupuis Frédérique , Pairot de Fontenay Benoit , Bouffard Jason , Bouchard Marc , Bouyer Laurent J. , Mercier Catherine , Roy Jean-Sébastien 
Published: March 2022

Abstract
Background
Experimental pain during gait has been shown to interfere with learning a new locomotor task. However, very few studies have investigated the impact of clinical pain on motor learning due to the challenges associated with clinical populations.

Objective
The first objective of this proof-of-concept study was to determine the feasibility to obtain two groups of participants with chronic ankle pathology with or without residual pain while walking. The second objective was to evaluate the impact of clinical musculoskeletal pain on motor learning during gait.

Methods
Participants with chronic isolated ankle pathology were recruited and their personal and clinical characteristics were collected (functional performance, dorsiflexion maximal strength, range of motion). To assess motor acquisition (Day 1) and retention (Day 2), participants performed an adaptation task on two consecutive days that consisted of walking while experiencing a perturbing force applied to the ankle. The level of pain during the task was measured, and participants who reported pain were attributed to the Pain group and participants without pain to the No Pain group. Learning performance was assessed by measuring ankle kinematics (Mean plantarflexion absolute error) and learning strategy was assessed by measuring the Relative timing of error and the tibialis anterior (TA) electromyographic activity.

Results
Twenty-five participants took part in the experiment. Eight (32%) were excluded because they could not be included in either the Pain or No Pain group due to the intermittent pain, leaving eight participants in the Pain group and nine in the No Pain group. Both groups were similar in terms of baseline characteristics. Musculoskeletal pain had no influence on learning performance, but the learning strategy were different between the two groups. The No Pain group showed a TA activity reduction before perturbation between the days, while the Pain group did not.

Conclusion
Some barriers were identified in studying musculoskeletal pain including the high rates of participants’ exclusion, leading to a small sample size. However, we showed that it is feasible to investigate clinical pain and motor learning. From the results of this study, musculoskeletal pain has no influence on motor learning performance but influences the learning strategy.
Acute pulmonary embolism and severe post thrombolysis renal bleeding, two deadly complications following mini-percutaneous nephrolithotomy: a rare case report
Authors: Wang Feng-Qi , Liu Wan-Zhang , Yuan He-Sheng , Huang Ting , Wang Zheng-Yi , Pan Jin-Feng , Yan Ze-Jun , Cheng Yue 
Published: March 2022

Abstract
Background
Acute pulmonary embolism and severe renal bleeding are two lethal postoperative complications, but there has been no report that involves both of them after mini-percutaneous nephrolithotomy.

Case presentation
A 62-year-old woman was admitted to our hospital with extremely severe hydronephrosis and multiple right renal calculi. After thorough examination, she received prone-position mini-percutaneous nephrolithotomy under spinal anaesthesia. Three days postoperatively, the patient complained of chest pain and dyspnea. Computed tomography pulmonary angiogram (CTPA) showed multiple embolisms in the left pulmonary artery and its branches. Symptoms were relieved after anticoagulant and thrombolysis therapy. On the 6th postoperative day, the patient developed shortness of breath, computed tomography angiography (CTA) showed massive hemorrhage in the right kidney, diffused contrast medium in the middle and lower part of the right kidney was seen during digital substraction angiography (DSA). Superselective right renal artery embolization (SRAE) was then applied using coil to occlude the responsible artery. The patient generally recovered under conscientious care and was approved to be discharged 26 days postoperatively.

Conclusions
This is the first case that involved both acute pulmonary embolism and severe post thrombolysis renal bleeding. The importance of D-dimer in the prediction and early detection of pulmonary embolism should be noted. For post thrombolysis renal bleeding, SRAE is considered as a reliable treatment.
Deleterious oral habits related to vertical, transverse and sagittal dental malocclusion in pediatric patients
Authors: Rodríguez-Olivos Lourdes Hilda Gabriela , Chacón-Uscamaita Pamela Roxana , Quinto-Argote Antony Germán , Pumahualcca Graciela , Pérez-Vargas Luis Fernando 
Published: March 2022

Abstract
Background
Malocclusion is highly reported among mixed dentition cases. Therefore, we aimed to determine the relationship of dental malocclusions in the vertical, transverse, sagittal planes with deleterious habits in pediatric patients.

Methods
A cross-sectional analytical study was carried out on 155 children aged 6–12 years attended at the clinic of the School of Dentistry of Universidad Nacional Mayor de San Marcos in 2017.

Results
Among 155 evaluated patients, 45.3% had vertical malocclusion, 52.0% had sagittal malocclusion and 13.6% had transverse malocclusion. The most frequent type of malocclusion in the vertical plane was anterior deep bite (22.2%), in the transverse plane, the edge-to-edge bite (7.1%) and the anterior crossbite (6.5%) were less frequent. Finally, in the sagittal plane, Class II Div 1 (20%) and Class III (20.7%) were the most frequent. Among the most common deleterious habits, anteroposition (58.7%) and mixed breathing (51.0%) were observed in contrast to the habit of retroposition, lip sucking and mouth breathing, which were the least frequent. Considering age and sex, children who have an atypical swallowing habit are more likely to have malocclusion in all three planes of space.

Conclusions
It is concluded that there is an association between the deleterious habits with the different types of malocclusions in the different planes of the space, being the atypical swallowing a habit that should be early diagnosed and treated interdisciplinary.
Menstrual hygiene management practice among adolescent girls: an urban–rural comparative study in Rajshahi division, Bangladesh
Authors: Ha Md. Abu Tal , Alam Md. Zakiul 
Published: March 2022

AbstractIntroductionAdolescence is a critical period characterized by significant physical, emotional, cognitive, and social changes, including the monthly occurrence of menstruation of adolescent girls. Despite being an inevitable natural event, most societies consider menstruation and menstrual blood as taboos and impure. Such consideration prevents many adolescent girls from proper health education and information related to menstrual health, which forces them to develop their ways of managing the event. This study attempted to explore the pattern, the urban–rural differences, and the determinants of menstrual hygiene management practices (MHMP) among adolescent girls in the Rajshahi division, Bangladesh.MethodologyUsing a cross-sectional study design with multistage random sampling, we collected data from 586 adolescent girls (aged 14–19 years) from the Rajshahi division of Bangladesh. The MHMP was measured using eight binary items, where the value from zero to five as ‘bad,’ six as ‘fair,’ and seven-eight as ‘good’ practices. Finally, we employed bivariate analysis and multinomial logistic regression analysis.FindingsOnly 37.7% continuously used sanitary pads. Among the cloth users, nearly three-fourths reused cloths, and about 57% used water and soap to wash them. About 49% changed menstrual absorbent, and 44% washed their genitalia three times daily. About 41% used water only to wash genitalia, and 55% buried sanitary materials under the soil. Around 36.9% of the girls practiced bad, 33.4% fair, and 29.7% good menstrual management. We found significant differences in MHMP among adolescent girls between urban and rural areas (32.3% vs. 27.7% good users,p ≤ 0.05). Multinomial logistic regression found that place of residence, age, family size, parental education, and age at first menstruation were the significant determinants of MHMP.ConclusionAlthough there are some cases of sanitary pad use, still menstrual hygiene management is unhealthy in most cases. The continuous supply of sanitary pads at affordable cost, change in existing social norms about menstruation, proper education, information, and services are essential for achieving health-related SDG goals in both rural and urban areas of Bangladesh.
Larrea divaricata: anti-inflammatory and antioxidant effects on macrophages and low density lipoproteins
Authors: Peralta Ignacio , Marrassini Carla , Saint Martin Malen , Cogoi Laura , Alonso María Rosario , Gugliucci Alejandro , Anesini Claudia 
Published: March 2022

AbstractBackgroundThe oxidized low density lipoprotein (ox-LDL) contributes to inflammation and oxidative stress through the activation of macrophages under hyperglycemia contributing to the development of diabetes mellitus and to atherosclerosis. Plants are a source of effective and innocuous antioxidants.Larrea divaricataCav. (Zygophyllaceae) is used in Argentina folk medicine for its anti-inflammatory properties.MethodsThe aim of this work was to study the antioxidant and anti-inflammatory effects of the aqueous extract (AE) ofL. divaricataon macrophages under glucose stimulation and on human LDL and HDL particles under free radical generators.ResultsAE reduced the lipid peroxidation (17%), nitric oxide (NO) (47-50%), tumor necrosis factor-α (TNF-α) (32%) and free radicals (50%) induced by glucose on macrophages. Also prevented HDL nitration (28%), thus preserving its function and structure and inhibited LDL oxidation. The effect on the nitrosative stress was mainly driven by nordihydroguaiaretic acid (NDGA).ConclusionsThese results suggest a potential usefulness of AE as an adjuvant phytotherapy in patients with diabetes mellitus and atherosclerosis.
Patients’ and providers’ perspectives on e-health applications designed for self-care in association with surgery – a scoping review
Authors: Wikström Lotta , Schildmeijer Kristina , Nylander Elisabeth Mueller , Eriksson Kerstin 
Published: March 2022

Abstract
Background
Before and after major surgery, access to information in a user-friendly way is a prerequisite for patients to feel confident in taking on the responsibility for their surgical preparation and recovery. Several e-health applications have been developed to support patients perioperatively. The aim of this review was to give an overview of e-health applications designed for self-care associated with surgery by providing a scoping overview of perspectives from providers and patients.

Methods
We searched the following data sources to identify peer-reviewed quantitative and qualitative studies published between 2015 and 2020: CINAHL, Google Scholar, MEDLINE, PsycInfo, Web of Science, and Scopus. After identifying 960 titles, we screened 638 abstracts, of which 72 were screened in full text. Protocol register: 10.17605/OSF.IO/R3QND.

Results
We included 15 studies which met our inclusion criteria. Data from several surgical contexts revealed that the most common self-care actions in e-health applications were preoperative preparations and self-assessments of postoperative recovery. Motivational factors for self-care were information, combined with supportive reminders and messages, and chat features. Although there was great variance in research designs and technical solutions, a willingness to engage with and adhere to e-health seemed to increase patients’ self-care activities and thereby accelerate return to work and normal activities. In addition, the need for physical visits seemed to decrease. Even though age groups were not primarily studied, the included studies showed that adult patients of any age engaged in surgical self-care supported by e-health. The providers’ perspectives were not found.

Conclusions
E-health applications supporting perioperative self-care indicated a positive impact on recovery. However, experiences of healthcare professionals delivering e-health associated with surgery are missing. Additionally, studies based on patients’ perspectives regarding willingness, adherence, and motivation for self-care supported by e-health are sparse. A need for studies examining the supporting role of e-health for self-care in the surgical context is therefore needed.
Knowledge support for ankle fractures in the Swedish Fracture Register – a qualitative study of physicians’ experiences
Authors: Rydberg Emilia Möller , Insulan Johan , Rolfson Ola , Mohaddes Maziar , Ahlstrom Linda 
Published: March 2022

Abstract
Background
The aim of this study is to investigate the experiences of physicians presented with a knowledge support system while registering data on ankle fractures in the Swedish Fracture Register. The present study aims to answer the following research questions:
• “How is receiving knowledge support while registering a fracture in the Swedish Fracture Register experienced by the physicians using it?”.
• “Can a feeling of increased usability of a quality register be achieved by providing the user with real-time feedback?”.

Methods
A total of 20 physicians using the Swedish Fracture Register were recruited using a purposive sampling strategy. Qualitative content analysis was performed on individual semi-structured interviews performed in May and June 2020.

Results
The present study demonstrates that the knowledge support system in the Swedish Fracture Register was perceived by the physicians as strengthening the evidence base and improving the quality of ankle fracture treatment. The knowledge support system was evaluated as a good tool for validating clinical decisions and managing the information that needs to be processed to make informed decisions.

Conclusions
The present study affirms that being provided with knowledge support is appreciated by physicians, increase value for work and enhance the initiative to register. The physicians experienced that the knowledge support provided an appreciated validation of the clinical decisions taken and a feeling of improved care. When incorporating knowledge support into an NQR, consideration must be given to physicians’ fears of becoming overly reliant on a template and losing control of the clinical base.
Role of indocyanine green in anomalous arterial supply to the normal dorsobasal segment of the lung
Authors: Iijima Yoshihito , Ishikawa Masahito , Iwai Shun , Motono Nozomu , Usuda Katsuo , Morinaga Masafumi , Yamagishi Shigeki , Koizumi Kiyoshi , Uramoto Hidetaka 
Published: March 2022

Abstract
Background
Anomalous systemic arterial supply to normal basal lung segments is a rare congenital malformation, in which aberrant arteries arising from the systemic circulation flow into the basal segment of the lung and return to normal pulmonary veins without abnormal bronchial branching. It presents a left-to-right shunt, resulting in volume overload of the pulmonary circulation, and consequently, pulmonary hypertension. Therefore, nearly all cases require surgery. Herein, we present a case, in which indocyanine green was used to demarcate the lung segment perfused by an anomalous systemic artery.

Case presentation
A 15-year-old boy was diagnosed with an anomalous artery originating from the celiac artery and supplying the right dorsobasal lung segment (S10). Via three-port video-assisted thoracoscopic surgery, the anomalous artery was ligated and processed with an auto-stapler. Indocyanine green was injected intravenously to identify the tissue perfused by the anomalous artery, and the lung was resected.

Conclusions
With anomalous systemic arterial supply to normal basal lung segments, indocyanine green can be particularly helpful in identifying the boundaries of the perfused area. Then, the affected tissue can be resected by thoracoscopic surgery.
Exploring the Y-Balance-Test scores and inter-limb asymmetry in soccer players: differences between competitive level and field positions
Authors: González-Fernández Francisco Tomás , Martínez-Aranda Luis Manuel , Falces-Prieto Moisés , Nobari Hadi , Clemente Filipe Manuel 
Published: March 2022

Abstract
Background
The postural stability seems to be important in the physical development of the soccer player and the specific tasks related to the game. In addition, it is related to the injury risk and therefore, with the injury prevention and retraining processes. In this context, the Y Balance Test (YBT) is presented as a tool to assess dynamic postural control.

Objective
This study aimed to explore the differences and possible correlations in the YBT scores and inter-limb asymmetry for anterior (ANT), posteromedial (PM) and posterolateral (PL) directions by category and field position in soccer players.

Methods
173 males soccer players aged between 14 and 33 years old agreed to participate. Five categories and six field position were considered in this study. A standardised protocol was used at multiple clubs during the pre-season assessment of musculoskeletal function in soccer players. All the players performed the Y Balance Test (YBT) (official YBT Kit), assessing the dominant and non-dominant leg for three YBT directions (anterior-AN, posteromedial-PM and posterolateral-PL), inter-limb asymmetry and composite score.

Results
For AN, amateur and semiprofessional obtained the highest values for Dominant and Non-Dominant legs (Rangemean = 101.8–109.4%) and the lowest level in PRO players (mean: 62.0%). Concerning PM-PL, semiprofessional (Rangemean = 126.4–132.7%, dominant and non-Dominant respectively), followed by professional and amateur reported higher scores compared to youth categories. Inter-limb asymmetry showed higher values in lower age categories. The best composite scores were detected in semiprofessionals (Rangemean = 113.3–126.7% for dominant and Rangemean = 113.8–129.7% for non-Dominant leg), compared with the rest of the categories and for each field position evaluated.

Conclusion
Comparisons between field-positions revealed that centre-backs were worse than wingers and forwards. In order to explain variations in dynamic balance between competitive levels within the same age-group, special considerations about training programmes and related co-variables should be considered.
Broad thermal spectrum metagenomic laccase with action for dye decolorization and fentin hydroxide treatment
Authors: Lima Natália Sarmanho Monteiro , Gomes-Pepe Elisângela Soares , Campanharo João Carlos , de Macedo Lemos Eliana Gertrudes 
Published: March 2022

AbstractLaccases are multicopper oxidases that act on various phenolic and non-phenolic compounds, enabling numerous applications including xenobiotic bioremediation, biofuel production, drug development, and cosmetic production, and they can be used as additives in the textile and food industries. This wide range of uses makes these enzymes extremely attractive for novel biotechnology applications. Here, we undertook the kinetic characterization of LacMeta, a predicted as homotrimeric (~ 107,93 kDa) small laccase, and demonstrated that this enzyme performs best at an acidic pH (pH 3–5) towards ABTS as substrate and has a broad thermal spectrum (10–60 °C), which can promote high plastic action potential through dynamic environmental temperature fluctuations. This enzyme showed following kinetic parameters: kcat = 6.377 s−1 ± 0.303, Km = 4.219 mM, and Vmax = 24.43 µM/min (against ABTS as substrate). LacMeta almost completely degraded malachite green (50 mg/mL) in only 2 h. Moreover, the enzyme was able to degrade seven dyes from four distinct classes and it respectively achieved 85% and 83% decolorization of methylene blue and trypan blue with ABTS as the mediator. In addition, LacMeta showed potential for the degradation of two thirds of an agricultural fungicide: fentin hydroxide, thus demonstrating its biotechnological aptitude for bioremediation. The results of this study suggest that LacMeta has potential in textile wastewater treatment and that it could help in the bioremediation of other human/environmental toxins such as pesticides and antibiotic compounds belonging to the same chemical classes as the degraded dyes.Graphical Abstract