bluuebunny/crossref_metadata_2025_split huggingface dataset:
GA/HbA1c ratio is a simple and practical indicator to evaluate the risk of metabolic dysfunction-associated fatty liver disease in type 2 diabetes: an observational study
Authors: Wang Jun-Wei , Jin Chun-Hua , Ke Jiang-Feng , Ma Yi-Lin , Wang Yu-Jie , Lu Jun-Xi , Li Mei-Fang , Li Lian-Xi 
Published: November 2022

Abstract
Background
It is still debatable whether glycated albumin/glycated hemoglobin A1C (GA/HbA1C) ratio is associated with metabolic dysfunction-associated fatty liver disease (MAFLD), and few studies have been conducted in type 2 diabetes mellitus (T2DM). Therefore, we aimed to investigate the association between GA/HbA1C ratio and MAFLD and to evaluate whether GA/HbA1C ratio can be used an indicator of MAFLD in Chinese patients with T2DM.

Methods
This cross-sectional study consisted of 7117 T2DM patients including 3296 men and 3821 women from real-world settings. Abdominal ultrasonography was performed to diagnose MAFLD. In addition to comparing the clinical characteristics among the GA/HbA1C ratio quartile groups, we also investigated the associations of GA/HbA1C ratio and quartiles with MAFLD in T2DM subjects.

Results
There was a significantly decreased trend in the MAFLD prevalence across the GA/HbA1C ratio quartiles (56.3%, 47.4%, 37.8%, and 35.6% for the first, second, third, and fourth quartile, respectively, P < 0.001 for trend) after adjusting for gender, age, and diabetes duration. Fully adjusted Binary logistic regression indicated that both GA/HbA1C ratio (OR: 0.575, 95% CI: 0.471 to 0.702, P < 0.001) and quartiles (P < 0.001 for trend) were inversely associated with the presence of MAFLD among T2DM patients. Additionally, HOMA2-IR values were clearly increased in the T2DM subjects with MAFLD compared with those without MAFLD (P < 0.001), and markedly increased from the highest to the lowest GA/HbA1C ratio quartile (P < 0.001 for trend).

Conclusions
GA/HbA1C ratio is closely and negatively associated with MAFLD in T2DM subjects, which may attribute to that GA/HbA1C ratio reflects the degree of insulin resistance. GA/HbA1C ratio may act as a simple and practical indicator to evaluate the risk of MAFLD in T2DM.
Why epigenetics is (not) a biosocial science and why that matters
Authors: Chiapperino Luca , Paneni Francesco 
Published: November 2022

AbstractEpigenetic modifications offer compelling evidence of the environmental etiology of complex diseases. Social and biographical conditions, as well as material exposures, all modulate our biology with consequences for risk predispositions and health conditions. Elucidating these complex biosocial loops is one of the main challenges animating epigenetics. Yet, research on the development of epigenetic biomarkers often pulls in a direction that departs from a view of biological determinants of health embedded in their social and material environment. Taking the example of the epigenetics of cardiovascular diseases, this paper illustrates how common understandings of epigenetic biomarkers strongly lean toward considering them as mere targets for molecular intervention, rather than as correlates of a complex biological and social patterning of disease. This reductionism about biosocial dynamics of disease, we argue, hampers the pursuit of the goals epigenetics has given itself (in cardiology and beyond). If epigenetic mechanisms point to the deep socio-environmental embeddedness of our health, we conclude, future designs and methods of this research may require an improved methodological consideration of a biosocial perspective.
Which indicator should be used? A comparison between the incidence and intensity of catastrophic health expenditure: using difference-in-difference analysis
Authors: Koo Jun Hyuk , Jung Hyun Woo 
Published: November 2022

Abstract
Background
Catastrophic health expenditure (CHE) represents out-of-pocket payment as a share of household income. Most previous studies have focused on incidence aspects when assessing health policy effects. However, because CHE incidence is a binary variable, the effect of the health policy could not accurately be evaluated. On the contrary, the intensity of CHE is a continuous variable that can yield completely different results from previous studies. This study reassesses the coverage expansion plan for four serious diseases using the intensity of CHE in Korea.

Methods
We used the Korea Health Panel Study from 2013 to 2015 to conduct the analysis. The study population is households with chronic diseases patients. We divided the population into two groups: the policy beneficiary group, i.e., households with a patient of any of the four serious diseases, and the non-beneficiary group. A difference-in-difference model was employed to compare the variation in the intensity and incidence of CHE between the two groups. We defined the incidence of CHE as when the ratio of out-of-pocket medical expenses to household income is more than a threshold of 10%, and the intensity of CHE is the height of the ratio subtracting the threshold 10%.

Results
The increased rate of CHE intensity in households with four serious diseases was lower than that in households with other chronic diseases. The interaction term, which represents the effect of the policy, has a significant impact on the intensity but not on the incidence of CHE.

Conclusions
CHE indicators should be applied differently according to the purpose of policy evaluation. The incidence of CHE should be used as the final achievement indicator, and the intensity of CHE should be used as the process indicator. Furthermore, because CHE has an inherent characteristic that is measured by the ratio of household income to medical expenses, to lower this, a differential out-of-pocket maximum policy for each income class is more appropriate than a policy for strengthening the coverage for specific diseases.
Diatom frustule silica extracted from Melosira nummuloides ameliorates acetaminophen-induced acute liver injury in mice
Authors: Choi Jae Ho , Go Gyung Min , Unno Tatsuya 
Published: November 2022

AbstractMelosira nummuloides is a type of diatom in the family Melosiraceae. Diatoms are unicellular microalgae widely distributed in aquatic environments. Diatoms are known to be suitable for many industrial and biomedical applications because of their high biocompatibility and ease of use. In this study, we investigated the hepatoprotective effect of diatom frustule silica (DFS) extracted from Melosira nummuloides on hepatotoxicant-induced liver injury. Hepatoprotective effects of DFS were examined using acetaminophen-induced acute liver injury (ALI) mouse model. We evaluated the hepatoprotective effects through hepatotoxicity, pro-inflammatory cytokines, transcriptional factors, upstream signaling pathways, and histopathological analysis by DFS in an animal model of acetaminophen-induced ALI. Our results showed serum alanine aminotransferase/aspartate aminotransferase activity and hepatic malondialdehyde formation were significantly attenuated upon DFS administration. DFS also ameliorated glutathione depletion and down-regulated acetaminophen-induced CYP2E1. DFS administration also down-regulated expressions of pro-inflammatory cytokines through preventing NF-κB activation by JNK1/2 phosphorylation inhibition. These findings demonstrate that the hepatoprotective effect of DFS is associated with suppression of inflammatory responses in an animal model of acetaminophen-induced ALI.
Coordinated cyber-physical attack considering false overload of lines
Authors: Yang Jun , Sun Guanhang , Yin Jianshu 
Published: November 2022

AbstractThe application of many sensor devices and complex information communication networks in a power system brings new potential threats to the electrical cyber-physical system. In this paper, a coordinated cyber-physical attack method considering false line overload is proposed. Through the combination of physical side attack and information side attack, the false data injection attack is used to cover up the physical attack and create false overload events, leading the dispatcher to make unreasonable scheduling strategies to achieve the purpose of affecting the economic operation of the system. In response to false overload events, this paper proposes a method to select the target line of false overload. At the same time, the output cost of the generator, the cost of load reduction and the number of overload lines are used as the evaluation indices to measure the damage capability of the coordinated attack, and the evaluation indices of different dimensions are normalized using fuzzy methods. Finally, the system losses caused by different attack modes are compared and analyzed through simulation calculations, and the effectiveness of the proposed model is verified.
Diversity of root endophytic bacteria from maize seedling involved in biocontrol and plant growth promotion
Authors: Cun Haichun , Munir Shahzad , He Pengfei , Wu Yixin , He Pengbo , Ahmed Ayesha , Che Hongbing , Li Jian , He Yueqiu 
Published: November 2022

Abstract
Background
Native endophytes from maize could play a vital role in plant protection and growth promotion. The present study was undertaken to elucidate the effect of soil types and different maize varieties on culturable endophytic bacterial diversity and to use potential endophytes as biocontrol agents and plant growth promoters.

Results
Based on rpoB and 16S rRNA genes, one hundred seventy-four (174) endophytes distributed into twenty-five (25) genera were identified, in which the greatest number of isolates were classified into Bacillus (52.30%), followed by Streptomyces (13.22%), Paenibacillus (6.32%), and Pseudomonas (4.60%). Out of the total isolated strains, endophytic strains with total number thirteen (13), eighty-four (84), one hundred and five (105), and nine (9) were able to fix nitrogen, and solubilize calcium phosphate, calcium phytate, and potassium, respectively. Moreover, out of total endophytes; twenty-four (24), thirty-three (33) and twenty-one (21) endophytic strains displayed marked antagonistic effects against important fungal pathogens such as Fusarium graminearum, Rhizoctonia solani and Exserohilum turcicum, respectively.

Conclusions
Soil types play a functional role in culturable endophyte diversity and provide an isolation reference for endophytic reserves with multiple functions such as growth promoters and biocontrol agents.
Hematological and biochemical reference intervals of wild-caught and inhouse adult Indian rhesus macaques (Macaca mulatta)
Authors: Shah Niraj A. , Bhatt Laxit K. , Patel Rajesh J. , Patel Tushar M. , Patel Nayankumar V. , Trivedi Harshida G. , Patel Nilam R. , Patel Jitendra H. , Patel Satish D. , Sundar Rajesh S. , Jain Mukul R. 
Published: November 2022

Abstract
Background
Nonhuman primates are used for research purposes such as studying diseases and drug discovery and development programs. Various clinical pathology parameters are used as biomarkers of disease conditions in biomedical research. Detailed reports of these parameters are not available for Indian-origin rhesus macaques. To meet the increasing need for information, we conducted this study on 121 adult Indian rhesus macaques (57 wild-sourced and 64 inhouse animals, aged 3–7 years). A total of 18 hematology and 18 biochemistry parameters were evaluated and reported in this study. Data from these parameters were statistically evaluated for significance amongst inhouse and wild-born animals and for differences amongst sexes. The reference range was calculated according to C28-A3 guidelines for reporting reference intervals of clinical laboratory parameters.

Results
Source of the animals and sex appeared to have statistically significant effects on reference values and range. Wild-born animals reported higher WBC, platelets, neutrophils, RBC, hemoglobin, HCT, MCV, and total protein values in comparison to inhouse monkeys. Sex-based differences were observed for parameters such as RBCs, hemoglobin, HCT, creatinine, calcium, phosphorus, albumin, and total protein amongst others.

Conclusions
Through this study, we have established a comprehensive data set of reference values and intervals for certain hematological and biochemical parameters which will help researchers in planning, conducting, and interpreting various aspects of biomedical research employing Indian-origin rhesus monkeys.
The association of kynurenine pathway metabolites with symptom severity and clinical features of bipolar disorder: An overview
Authors: Bartoli Francesco , Cioni Riccardo M. , Cavaleri Daniele , Callovini Tommaso , Crocamo Cristina , Misiak Błażej , Savitz Jonathan B. , Carrà Giuseppe 
Published: November 2022

Abstract

Background
The balance between neurotoxic and neuroprotective effects of kynurenine pathway (KP) components has been recently proposed as a key element in the pathophysiology of bipolar disorder (BD) and related mood episodes. This comprehensive overview explored the link of KP with symptom severity and other clinical features of BD.

Methods
We searched Medline, Embase, and PsycInfo electronic databases for studies assessing the association of peripheral and/or central concentrations of KP metabolites with putative clinical features, including symptom severity and other clinical domains in BD.

Results
We included the findings of 13 observational studies investigating the possible variations of KP metabolites according to symptom severity, psychotic features, suicidal behaviors, and sleep disturbances in BD. Studies testing the relationship between KP metabolites and depression severity generated mixed and inconsistent findings. No statistically significant correlations with manic symptoms were found. Moreover, heterogeneous variations of the KP across different clinical domains were shown. Few available studies found (a) higher levels of cerebrospinal fluid kynurenic acid and lower of plasma quinolinic acid in BD with psychotic features, (b) lower central and peripheral picolinic acid levels in BD with suicide attempts, and (c) no significant correlations between KP metabolites and BD-related sleep disturbances.

Conclusions
An imbalance of KP metabolism toward the neurotoxic branches is likely to occur in people with BD, though evidence on variations according to specific clinical features of BD is less clear. Additional research is needed to clarify the role of KP in the etiopathogenesis of BD and related clinical features.
Text, Materiality, and Enshrinement Practices: Visual Culture of a BuddhistDhāraṇīin Late Medieval Korea
Authors: Lee Seunghye 
Published: November 2022

AbstractThis article examines woodblock prints of the Sūtra of the Dhāraṇī of the Precious Casket Seal of the Concealed Complete-Body Relics of the Essence of All Tathāgatas, a short text that came to serve as a backbone for the textual relic cult and, starting in the early Koryŏ, became an important part of consecratory deposits of Buddhist icons. This article focuses on how material embodiments of dhāraṇīs were enshrined in the Korean context and how such enshrinement defined their function and meaning. Through an analysis of the Dhāraṇī of the Precious Casket Seal in diverse forms, visual designs, and ritual contexts from the eleventh to the fourteenth century, the article demonstrates that the materiality of this important dhāraṇī was key to its performativity as a sacred object that could consecrate otherwise manmade architectural or iconic entities. By so doing, this study reveals key aspects of the Buddhist visual culture that have long remained obscure, while contributing to the growing scholarship on textual materiality in premodern Korea.
Kim Chŏnghŭi and His Epigraphic Studies: Two Silla Steles and Their Rubbings
Authors: Shin Jeongsoo 
Published: November 2022

Abstract
Theoretically, ink rubbings are secondary to the steles they come from, but they served as primary sources for epigraphers who were more interested in literati inscriptionality than they were in the three-dimensional monumentality of the steles. In this shifting status of the two media, textual form and calligraphic style play a subtle yet critical role in the appreciation of inscriptions. Beginning in the late eighteenth and early nineteenth centuries, scholars in China and Korea exchanged rubbings of ancient steles to build friendships. Conflicting interpretations, however, arose when discussing the calligraphic style of Korean inscriptions. Chinese fascination with Korean steles is understood as part of their investigation into the remnants of Chinese heritage on the Korean peninsula. Korean scholars, in turn, attempted to suggest that Korean culture kept abreast with that of China from early times onward. Using two case studies of the Mujangsa and Hwangch’oryŏng Steles, this article discusses how self-serving agendas motivated scholars of both countries.
North Korean Calligraphy: Gender, Intimacy, and Political Incorporation, 1980s–2010s
Authors: Chizhova Ksenia 
Published: November 2022

AbstractA ubiquitous part of everyday life, North Korean calligraphy is an easily overlooked and yet integral element of the country’s mass mobilization art. Under the curation of Kim Jong Il (Kim Chŏngil, 1941–2011), calligraphy was mobilized as a mechanism for the articulation of organistic national unity centered on the ruling Kim family and captured through the idea of the “social and political living body” (sahoe chŏngch’i chŏk saengmyŏngch’e), which mediated the familial transition of power. Cultivating penmanship identical to that of his father and expanding the hagiographic project around the revolutionary calligraphy of his parents, Kim Il Sung (Kim Ilsŏng, 1912–94) and Kim Jong Suk (Kim Chŏngsuk, 1917–49), Kim Jong Il worked out an image of charismatic familial embodiment by means of the script. In addition, calligraphy constitutes a disciplinary apparatus that coordinates performances of political intimacy, bodily training, and political interpretation within the space of everyday life. Drawing on the North Korean calligraphy textbooks, art periodicals, and visual archive, this article contextualizes the dichotomy of the idiosyncratic style of the male leaders and the feminized, ubiquitous Ch’ŏngbong style, connected with the figure of Kim Jong Suk. Special attention is given to the body symbolism and somatic discipline of North Korean calligraphy, which underlie its political efficacy as inscriptional and hermeneutic practice.
Mothers, Daughters, and the Lash
Authors: Baker Courtney R. 
Published: November 2022

AbstractThis essay examines women’s literary mourning as expressed in the trope of lashing in Toni Morrison’s 2008 novel A Mercy. Structural ties, bonds, and lashes grant affective bonds in A Mercy a dangerous and sometimes lethal edge. This essay examines the fraught bonding and binding—or, to use the language of A Mercy, the lashing—that deforms the relationship between mothers and daughters and produces an archive of intergenerational mourning that struggles to be transmitted and deciphered. This essay seeks to understand how language and affective bonds influence the narrative management of women’s bodies and the form of the novel itself. The invitation to mourn extends beyond the book’s characters and to the reader. A Mercy disturbs the potentially stabilizing authority of the written word, expanding the practice of literary mourning from the world of the book to the world of the book’s reader. Lashed to a language that promises our undoing, the reader—like the women in the novel—confronts the originary violences of patriarchy, settler colonialism, and slavery that define the newness of the “New World.”
Health literacy on COVID-19 and COVID-19 vaccinations in Indonesia
Authors: Kalanjati Viskasari P. , Hasanatuludhhiyah Nurina , d'Arqom Annette , Muhammad Azlin , Marchianti Ancah Caesarina Novi , Arsyi Danial H. , Permana Putu Bagus Dharma , Susila I Made Dwi Yudiartana Putra , Pratiwi Octaviana Galuh , Purwitasari Diana 
Published: November 2022

Introduction: Health literacy on the coronavirus disease 2019 (COVID-19) affects people’s capability to ascertain their health and health care quality during the pandemic. The objective of this study was to determine the levels of health literacy about COVID-19 vaccines and vaccinations (Vaccines and Vaccinations literacy-VL) in the Indonesian adult general population, assessing the perceptions of the respondents about current adult immunization and beliefs about vaccinations in general, and analyzing correlations of these variables with the VL levels. Methods: A cross-sectional study using a rapid survey was administered via the Internet. Data were analyzed using descriptive and inferential statistics; the internal consistency of the VL scales was evaluated using Cronbach’s alpha coefficient; the inter-correlation between the functional and interactive-critical VL questions, the underlying components (factors) and each question’s load on the components were identified using a Principal Component Analysis (PCA). An alpha level lesser than 0.05 was considered significant. Results: Responses to functional- and interactive/ critical- VL questions were acceptable and showed internal consistency (Cronbach’s alpha = 0.817 and 0.699, respectively), lowest values observed were 0.806 for functional scale and 0.640 for the interactive-critical scale. The PCA demonstrated that there were two components accounting for 52.45% of the total variability. Approximately 60% of respondents were females (n=686). Almost all respondents used the internet to seek information regarding COVID-19 and COVID-19 vaccinations. Many used at least one social media actively with 74.4% of respondents sometimes believing the validity of this information. Conclusions: High scores were observed in both functional- and interactive/ critical-VL, and were quite in a balance between sexes in the prior VL and higher in females for the latter; these were also closely related to the educational level and age group. It is crucial to increase public health literacy in managing the pandemic.
Clinical spectrum and short-term outcome of post-COVID multisystem inflammatory syndrome in children after the 2019 pandemic: a longitudinal cohort study
Authors: Kumar Sudesh , Bhattacharya Piyali , Arya Nikhil , Kumari Anamika , Chattopadhyay Nandita 
Published: November 2022

Background As a post-COVID complication in children, multisystem inflammatory syndrome in children (MIS-C) is important because of its varied and life-threatening manifestations. With this background, this study attempts to focus on MIS-C cases in an underprivileged rural setting in north-eastern India, with most patients being treated with methylprednisolone rather than intravenous immunoglobulin due to financial constraints. Methods In this prospective longitudinal cohort study at MGM Medical College, 27 MIS-C cases diagnosed following WHO criteria were included. Laboratory and radiological investigations, including echocardiography, were performed as required for diagnosis and to assess prognosis. Most patients were treated with methylprednisolone. A follow-up assessment was done six weeks after discharge for any residual impairment. Results The most frequently affected age group was 5–10 years (59.28%), while respiratory (48.14%) and cardiac (40.74%) were the most commonly involved systems. Logistic regression studies established a significant association between serum ferritin level and prolonged hospital stay (coefficient 0.0674, p=0.0041), possibly due to greater complications in cases with high ferritin levels. Organ impairment was found to increase the need for inotrope use (coefficient 3.8797, p=0.00584). Most cases were treated with methylprednisolone alone (85.18%) with a favourable response and no death occurred. Conclusion The favourable response in cases treated with methylprednisolone only affirms the effectiveness of the drug as a cheaper alternative in a resource-poor setting. The study highlights that higher ferritin levels in complicated cases leads to prolonged hospitalisation and the increased need for inotropes in cases with organ impairment.