bluuebunny/crossref_metadata_2025_split huggingface dataset:
Influence of dietary fiber intake and soluble to insoluble fiber ratio on reproductive performance of sows during late gestation under hot climatic conditions
Authors: Moturi Joseph , Hosseindoust Abdolreza , Tajudeen Habeeb , Mun Jun Young , Ha Sang Hun , Kim Jin Soo 
Published: November 2022

AbstractThis study evaluated dietary fiber (DF) level and the ratio of soluble fiber (SF): insoluble fiber (ISF) impact on sows’ reproductive performance under heat stress. Forty sows at day 90 of gestation were assigned to four treatments. HH diet had, 20% DF, 1:4, SF:ISF ratio; HL, 20% DF, 1:6, SF:ISF ratio; LH, 14% DF, 1:4, SF:ISF, LL, 14% DF, 1:6, SF:ISF. Results showed that; lactation back-fat loss was lower (P < 0.05) in HH . Feed intake was higher (P < 0.05) in HH and HL. Farrowing duration shorter (P < 0.05) in HH. Constipation index was higher (P < 0.05) in HH and LH. Weaning piglets’ body weight was greater (P < 0.05) in HH than LH and LL. Hair cortisol was lower (P < 0.05) in HH than HL, and LL. Acetate, propionate, isovalerate, and butyrate was higher (P < 0.05) in HH and LH. Plasma zonulin, fecal lipocalin-2 were lower (P < 0.05) in HH, and HL. Superoxide dismutase tended to be higher (P = 0.056) and malondialdehyde tended to be lower (P = 0.069) in HH and HL. We opined that higher levels of dietary fiber and soluble fiber could ameliorate heat stress in gestating sows.
DLGAP4 acts as an effective prognostic predictor for hepatocellular carcinoma and is closely related to tumour progression
Authors: Dong Cairong , Huang Shenglan , Sun Liang , Yao Jinping , Yan Jinlong , Yin Xiangbao 
Published: November 2022

AbstractDisc large associated protein 4 (DLGAP4) plays an important role in neurological diseases, but the role and mechanism of DLGAP4 in hepatocellular carcinoma (HCC) remain unclear. In this study, the prognostic effect of DLGAP4 on HCC patients was investigated by means of bioinformatics. The correlation of DLGAP4 expression with the prognosis of HCC patients was evaluated by TCGA data analysis, and the correlation between DLGAP4 expression and the clinical characteristics of HCC patients was evaluated by the Wilcoxon signed rank test and logistic regression analysis. Kaplan‒Meier and Cox regression methods were used to assess the effect of DLGAP4 expression level on overall survival, and nomograms were used to illustrate the correlation between DLGAP4 gene expression and HCC risk. The genes related to DLGAP4 in HCC were screened, and GO/KEGG enrichment analysis was performed. Furthermore, in vitro and in vivo experiments were conducted to detect the effect of DLGAP4 expression on the proliferation, migration and metastasis of HCC cells. We also examined the effect of DLGAP4 expression on enriched pathway proteins to explore the possible mechanism. The expression levels of DLGAP4 were significantly higher in HCC cell lines and tissue samples than in normal liver cell lines and tissues. The expression of DLGAP4 was significantly associated with clinical characteristics. Survival analysis showed that high expression of DLGAP4 was associated with a poor prognosis in HCC. Multivariate analysis showed that high expression of DLGAP4 was an independent risk factor affecting the overall survival rate in HCC patients. By means of ROC curve analysis and nomograms, we determined the value of DLGAP4 expression in the diagnosis and prognosis evaluation of HCC. GO/KEGG enrichment analysis showed that the PPAR signalling pathway was differentially enriched in patients with high expression of DLGAP4. According to in vitro and in vivo experiments, DLGAP4 knockdown inhibited the proliferation and metastasis of HCC cells and decreased the expression of PPARβ/δ protein. In contrast, overexpression of DLGAP4 promoted the proliferation and metastasis of HCC cell, and increased the expression of PPARβ/δ protein.In contrast, overexpression of DLGAP4 promoted the proliferation and metastasis of HCC cells and increased the expression of PPARβ/δ protein. The results show a close correlation between DLGAP4 expression and clinicopathological features of HCC, and DLGAP4 can be used as a prediction biomarker of HCC.
Influence of tillage systems and sowing dates on the incidence of leaf spot disease in Telfairia occidentalis caused by Phoma sorghina in Cameroon
Authors: Kpu Kebei Andrew , Annih Mbong Grace , Ambang Agyingi Lucy , Agwah Ebile Dayan 
Published: November 2022

AbstractThe production and leaf quality of Telfairia occidentalis in Cameroon are gravely threatened by leaf spot disease. A field study was conducted in July 2019 and 2020 to determine the influence of tillage systems and sowing dates on the incidence of Telfairia occidentalis leaf spot caused by Phoma sorghina. A randomized block design with three replications and four planting dates was used. The soil physicochemical properties were also determined. Data for disease incidence were registered once every two weeks and submitted to generalized linear model for statistical analysis. The means were separated by Duncan’s multiple range test at a 95% confidence interval. Calculations for disease incidence and statistical analysis were conducted using the Microsoft Excel program and SPSS version 23, respectively. Statistical analysis revealed that the zero tilled field generally registered a lower leaf spot disease incidence than the tilled field, which was highly significant (p ≤ 0.05). In addition, the second sowing date in the zero tilled field proved to be better in terms of low disease incidence than other sowing dates employed in the study. Therefore, to minimize the devastating effects of leaf spot disease, zero tillage coupled with the second sowing date could be exploited.
Hall current effect in bioconvection Oldroyd-B nanofluid flow through a porous medium with Cattaneo-Christov heat and mass flux theory
Authors: Khan Noor Saeed , Sriyab Somchai , Kaewkhao Attapol , Thawinan Ekkachai 
Published: November 2022

AbstractBioconvection due to microorganisms is important area of research, considerably importance for environment and sustainable fuel cell technologies. Buongiorno nanofluid model for Cattaneo-Christov heat and mass flux theory taken into account the Oldroyd-B nanofluid and gyrotactic microorganisms in a rotating system with the effects of Hall current, and Darcy porous medium is scrutinized. The constitutive equations of the problem are transformed into nondimensional equations with the help of similarity transformations. Homotopy analysis method is used to obtain the solution. Graphs and table support the comprehesive representation of the achieved results. Radial velocity is reduced with the increasing values of relaxation time, retardation time and magnetic field parameters while heat transfer is augmented with thermal relaxation time parameter. The nanoparticles concentration is reduced with the increasing values of Schmidt number and the gyrotactic microorganisms concentration is enhanced with the increasing values of Peclet number. A nice agreement is obtained while comparing the present results numerically with the published results. The proposed mathematical model is used in biochemical engineering, meteorology, power and transportation production, optoelectronic and sensing microfabrication.
Ultimate figures of merit broadband self-powered obliquely deposited antimony thin film laser detectors
Authors: Hamoudi Walid K. , Ismail Raid A. , Ismail Munaf R. 
Published: November 2022

AbstractFabrication of a fast and high detectivity infrared detector operating at room temperature represents a big challenge. Due to the small energy gap of the semiconducting materials used for infrared detectors, the noise becomes considerable factor and the possibility of operating the detector at room temperature is very limited. A study of the figures of merit antimony thin films detector grown by oblique angle deposition technique is presented. Polycrystalline antimony thin films were thermally evaporated on the glass substrates at a angles of 0, 10, 30, and70°. The aim was to develop a wideband (0.649–10.6) µm self-powered laser detectors; operating at room temperature. The deposition angle had a decisive role in the detector specifications, namely, its detectivity, responsivity, linearity, and response time. At θ = 70° deposition angle; maximum detectivity and fastest response were achieved. The variation of rise time with deposition angle was linear, and the rise time was around 50 ns at 70°. The antimony detectors showed about the same specific detectivity ~ 109 Jones at 300 k for the wavelength range of 1.064–10.6 µm.
Adsorption of Carvone and Limonene from Caraway essential oil onto Tunisian montmorillonite clay for pharmaceutical application
Authors: Agougui Chaima , Cecilia Juan Antonio , Saad Houda , Franco-Duro Francisco , Essid Rym , Khabbouchi Mohamed , Frini-Srasra Najoua 
Published: November 2022

AbstractTo explore a novel kind of green composite material having excellent antibacterial, antifungal ability and specific-targeting capability for pharmaceutical uses, a novel kind of bio-composite was prepared using sodium purified clay as carrier of Caraway essential oil (CEO). Gas chromatography-mass spectroscopy (GC–MS) analyses of CEO reveals that Carvone (68.30%) and Limonene (22.54%) are the two major components with a minimum inhibitory concentration (MIC) value equal to 125 mg/mL against Staphylococcus (S) aureus bacteria and Candida albicans fungi. Clay from Zaghouan was purified and characterized by X-ray Photoelectron Spectroscopy (XPS), X-ray diffraction (XRD), Fourier transformed infrared spectroscopy (FT-IR) and N2 adsorption–desorption (BET method). Results obtained by chromatograph equipped with a flame ionization detector (GC-FID) show that the concentration of 130 mg/mL of essential oil and 5 h of contact with the purified clay are the optimal conditions for the bio-hybrid formation. The pseudo-second-order model can describe the kinetic study of the adsorption of Carvone and Limonene on sodium montmorillonite, and the adsorption isotherms have been established to the Langmuir type. Limonene registers a maximum adsorption value equal to 3.05 mg/g of clay however Carvone register the higher amount of adsorption (19.98 mg/g) according to its polarity and the abundance of this compound in the crude CEO. X-ray diffraction, Fourier transformed infrared spectroscopy, elemental analyses (CHN) and X-ray fluorescence characterization valid the success adsorption of CEO in sodium montmorillonite surface. The purified clay/CEO hybrid (purified clay/CEO) combined the advantages of both the clay and the essential oil used in exerting the antibacterial and antifungal activity, and thus, the composite has a double antibacterial and antifungal activity compared to the separately uses of inactive clay and CEO, suggesting the great potential application in pharmaceutical treatments.
Fluorescent silica nanoparticles as an internal marker in fruit flies and their effects on survivorship and fertility
Authors: Songvorawit Nut , Phengphuang Photchara , Khongkhieo Thitinat 
Published: November 2022

AbstractTracking and differentiating small insects at the individual levels requires appropriate marking materials because of their small size. This study proposes and investigates the use of fluorescent silica nanoparticles (FSNPs) as an internal marker owing to their good optical properties and biocompatibility. FSNPs were prepared using the water-in-oil reverse microemulsion technique with Rubpy dye as a fluorophore. The obtained particles were spherical, monodispersed in nanosize and exhibited bright orange luminescence under ultraviolet (UV) light. Internal marking was accomplished in fruit flies (Drosophila melanogaster) through feeding. The result shows that the fruit flies exhibit bright luminescence in their abdomen when exposed to UV light. The marking persistence duration of FSNPs in the fruit fly bodies is longer than those of other fluorescent dyes. Fruit flies fed with FSNPs have a longer lifespan than those fed with Rubpy dye. There was no difference in fertility and negative geotaxis response among the treatment and control groups. These findings demonstrate that FSNPs can be used as an internal marker in fruit flies, and are possibly applied with other small insects with a translucent abdomen.
Prevalence and correlation of C-shaped root canals of mandibular premolars and molars in Eastern Chinese individuals
Authors: Chen Cheng , Zhu Tingting , Wu Huili , Zhao Xiao , Leng Diya , Wang Jingyan , Yang Lianfeng , Wu Daming 
Published: November 2022

AbstractThe aim of this study was to investigate the prevalence, correlation, and differences of C-shaped root canals (CSRCs) morphology in permanent mandibular premolars and molars in Eastern Chinese individuals using cone-beam computed tomography (CBCT). A total of 8000 mandibular first premolars (MFPs), mandibular second premolars (MSPs), mandibular first molars (MFMs), and mandibular second molars (MSMs) CBCT images from 1000 patients (692 females and 308 males) were collected. The prevalence, correlation, bilateral/unilateral presence, the morphology of CSRCs, level of canal bifurcation, gender differences, and location of radicular grooves (RGs) were evaluated. The prevalence of CSRCs in MFPs, MSPs, MFMs and MSMs were 10.25%, 0.25%, 0.55% and 47.05%, respectively. The prevalence of CSRCs in MFPs of males was higher than that in females, while the prevalence of CSRCs in MSMs of females was higher than that in males (P < 0.05). The bilateral symmetry presence of CSRCs in MSMs was significant but not in MFPs, MSPs, and MFMs. RGs were predominantly found on the mesiolingual (ML) surface of premolars and the lingual surface of molars. There was a high prevalence of CSRCs in MFPs and MSMs in the Eastern Chinese population, but there was no correlation. The prevalence of CSRCs in MFPs and MSMs differ significantly by gender (P < 0.05).
Disentangling the nature of the prototype radio weak BL Lac
Authors: Marchesini E. J. , Reynaldi V. , Vieyro F. , Saponara J. , Andruchow I. , López I. E. , Benaglia P. , Cellone S. A. , Masetti N. , Massaro F. , Peña-Herazo H. A. , Chavushyan V. , Combi J. A. , Acosta-Pulido J. A. , Agís González B. , Castro-Segura N. 
Published: November 2022

Context. The γ-ray emitting source WISE J141046.00+740511.2 has been associated with a Fermi-LAT detection by crossmatching with Swift/XRT data. It has shown all the canonical observational characteristics of a BL Lac source, including a power-law, featureless optical spectrum. However, it was only recently detected at radio frequencies and its radio flux is significantly low.
Aims. Given that a radio detection is fundamental to associate lower-energy counterparts to Fermi-LAT sources, we aim to unambiguously classify this source by performing a multiwavelength analysis based on contemporaneous data.
Methods. By using multifrequency observations at the Jansky Very Large Array, Giant Metrewave Radio Telescope, Gran Telescopio Canarias, Gemini, William Herschel Telescope and Liverpool observatories, together with Fermi-LAT and Swift data, we carried out two kinds of analyses. On one hand, we studied several known parameters that account for the radio loudness or weakness characterization and their application to blazars (in general) and to our source (in particular). And, on the other hand, we built and analyzed the observed spectral energy distribution (SED) of this source to try to explain its peculiar characteristics.
Results. The multiwavelength analysis indicates that WISE J141046.00+740511.2 is a blazar of the high-frequency peaked (HBL) type that emits highly polarized light and that is likely located at a low redshift. In addition, the one-zone model parameters that best fit its SED are those of an extreme HBL (EHBL); this blazar type has been extensively predicted in theory to be lacking in the radio emission that is otherwise typical of canonical γ-ray blazars.
Conclusions. We confirm that WISE J141046.00+740511.2 is indeed a highly polarized BL Lac of the HBL type. Further studies will be conducted to explain the atypical low radio flux detected for this source.
Tonometrie: Rückblick und Ausblick (Teil 1)
Authors: Yaïci Rémi , Geerling Gerd 
Published: November 2022

ZusammenfassungDer intraokulare Druck (IOD) ist ein wichtiger physikalischer Parameter der
Physiologie des Auges. Ein erhöhter IOD wurde früh als Ätiologie für
Augenerkrankungen vermutet. In diesem 1. Teil des Beitrags wird neben den
physiologischen Grundlagen die Kontakttonometrie vorgestellt, die sowohl die
erste instrumentelle Methode mit den Indentationstonometern als auch den
Goldstandard mit dem Goldmann-Applanationstonometer darstellt.
Additive-Free Synthesis of 3H-1,2,4-Triazol-3-ones via a Formal [3+2] Cycloaddition Reaction of Hydrazonoyl Chlorides with KOCN
Authors: Yavari Issa , Golmoradi Fateh , Khaledian Omid 
Published: November 2022

AbstractA direct and speedy approach for the synthesis of 1,5-disubstitued-3H-1,2,4-triazol-3-ones via a formal [3+2] cycloaddition reaction of hydrazonoyl chlorides with KOCN is described. The reaction proceeds in EtOH at room temperature with no need for any base and catalyst. KCl is the sole byproduct of this efficient synthetic procedure which can be isolated after reaction completion using water in which the products precipitated.
A Synthesis of Furan-2-iminophosphoranes under Appel-Type Reaction Conditions
Authors: Yavari Issa , Saffarian Hamed , Khaledian Omid 
Published: November 2022

AbstractPhenacylmalononitriles reacted with triphenylphosphine and carbon tetrachloride in an Appel-type, cyclization/aromatization reaction to afford 5-aryl-2-[(triphenylphosphoranylidene)amino]-3-furonitriles in yields of 75–92%. The reaction proceeded smoothly in the presence of excess amounts of Ph3P and CCl4 without any base or catalyst at room temperature. The structure of one product was confirmed by X-ray crystallographic analysis.
Synthesis of 1H-Isochromenes and 1,2-Dihydroisoquinolines by Indium(III)-Catalyzed Cycloisomerization of ortho-(Alkynyl)benzyl Derivatives
Authors: Sarandeses Luis A. , Sestelo José Pérez , Seoane-Carabel Fabio , Alonso-Marañón Lorena 
Published: November 2022

Abstract1H-Isochromenes and 1,2-dihydroisoquinolines are synthesized by regioselective indium(III)-catalyzed intramolecular hydrofunctionalization of o-(alkynyl)benzyl derivatives. The reaction with o-(alkynyl)benzyl alcohols and amines proceeds using indium triiodide (5–10 mol%) in toluene at 80–100 °C via regioselective 6-endo-dig intramolecular alkyne hydroalkoxylation or hydroamination in good yields. Alternatively, the cycloisomerization reaction of o-(alkynyl)benzaldehydes and imine derivatives using InI3 (5 mol%) and the Hantzsch ester (120 mol%) takes place, under milder reaction conditions, to give a variety of functionalized 1H-isochromenes and 1,2-dihydroisoquinolines through a domino cycloisomerization/reduction approach.
Recent Developments in Isoindole Chemistry
Authors: Wang Xiang , Weintraub Rachel A. 
Published: November 2022

AbstractIsoindoles are highly reactive aromatic heterocycles that have a variety of important applications in areas such as medicine, analytical detection, and solar energy. Due to their highly reactive nature, isoindoles can be used to access their derivatives, which possess a diverse array of biological activities. However, their reactivity also makes isoindoles unstable and thus, difficult to prepare. Consequently, there has been a need for the development of novel methods that address some of the synthetic challenges and limitations, as well as reactions that utilize isoindoles to access potentially useful compounds. This review will give an overview of the novel reactions reported within the past decade (2012 to 2022) that involve 2H- and 1H-isoindoles and fused isoindoles as reactants, key intermediates, or products. This review is divided into two parts, with the first part focusing on the synthesis of isoindoles and the second part focusing on reactions of isoindoles. The scopes and limitations of the methods described therein will be discussed and the significance of their contributions to the literature will be highlighted. Similar reactions will also be compared.1	Introduction2	Synthesis of Isoindoles2.1	Synthesis of 2H-Isoindoles2.2	Synthesis of 1H-Isoindoles3	Reactions of Isoindoles3.1	Reactions of 2H-Isoindoles3.2	Reactions of 1H-Isoindoles4	Conclusions
A Brief Review of Thrombolytics for Venous Interventions
Authors: Grewal Sukhdeep K. , Hedrick Amanda L. , Man Louise , Sharma Aditya M. , Desai Kush R. , Khaja Minhaj S. 
Published: November 2022

AbstractAnticoagulation continues to be the mainstay of therapy for the management of venous thromboembolism. However, anticoagulation does not lead to the breakdown or dissolving of the thrombus. In an acute pulmonary embolism, extensive thrombus burden can be associated with a high risk for early decompensation, and in acute deep venous thrombosis, it can be associated with an increased risk for phlegmasia. In addition, residual thrombosis can be associated with chronic thromboembolic pulmonary hypertension and postthrombotic syndrome in a chronic setting. Thrombolytic therapy is a crucial therapeutic choice in treating venous thromboembolism for thrombus resolution. Historically, it was administered systemically and was associated with high bleeding rates, particularly major bleeding, including intracranial bleeding. In the last two decades, there has been a significant increase in catheter-based therapies with and without ultrasound, where lower doses of thrombolytic agents are utilized, potentially reducing the risk for major bleeding events and improving the odds of reducing the thrombus burden. In this article, we provide an overview of several thrombolytic therapies, including delivery methods, doses, and outcomes.
Antithrombotic Therapy after Deep Venous Intervention
Authors: Xiao Nicholas , Genet Matthew , Khaja Minhaj , Desai Kush R. 
Published: November 2022

AbstractChronic deep venous disease (CVD) can result in significant morbidity and impact on quality of life due to a spectrum of symptoms, including lower extremity edema, venous claudication, and venous ulcers. CVD can be secondary to both thrombotic and nonthrombotic disease processes, including postthrombotic syndrome from prior deep vein thrombosis (DVT) or iliac vein compression syndrome. Endovascular therapy has become a mainstay therapy for CVD patients, with venous stent placement frequently performed. However, the management of anticoagulation following venous stent placement is not well-studied, with no large trials or consensus guidelines establishing an optimal regimen. The current knowledge gap in antithrombotic therapy is magnified by heterogeneity in practice and data collection, along with incomplete reporting in available studies. Furthermore, most published datasets are antiquated in the setting of rapid evolution in technique and technology available for deep venous intervention. Herein, we summarize the current available literature and offer an approach to anticoagulation and antiplatelet management following deep venous intervention for CVD.