bluuebunny/crossref_metadata_2025_split huggingface dataset:
Natural Plant Tissue with Bioinspired Nano Amyloid and Hydroxyapatite as Green Scaffolds for Bone Regeneration
Authors: Li Yuzhou , Fu Yiru , Zhang He , Wang Xu , Chen Tao , Wu Yanqiu , Xu Xinxin , Yang Sheng , Ji Ping , Song Jinlin 
Published: March 2022

AbstractBone defects have been increasingly prevalent around the globe and traditional bone substitutes are constantly limited by low abundance and biosafety due to their animal‐based resources. Plant‐based scaffolds are currently studied as a green candidate but the bioinertia of cellulose to mammalian cells leads to uncertain bone regeneration. Inspired by the cross‐kingdom adhesion of plants and bacteria, this work proposes a concept of a novel plant bone substitute, involving coating decellularized plant with nano amyloids and nano hydroxyapatites, to bridge the plant scaffold and animal tissue regeneration. Natural microporosity of plants can guide alignment of mammalian cells into various organ‐like structures. Taking advantage of the bioactive nano amyloids, the scaffolds drastically promote cell adhesion, viability, and proliferation. The enhanced bio‐affinity is elucidated as positively charged nano amyloids and serum deposition on the nanostructure. Nano‐hydroxyapatite crystals deposited on amyloid further prompt osteogenic differentiation of pre‐osteoblasts. In vivo experiments prove successful trabeculae regeneration in the scaffold. Such a hierarchical design leverages the dedicated microstructure of natural plants and high bioactivity of nano amyloid/hydroxyapatite coatings, and addresses the abundant resource of bone substitutes. Not limited to their current application, plant materials functionalized with nano amyloid/hydroxyapatite coatings allow many cross‐kingdom tissue engineering and biomedical applications.
Bipolar Metal Flexible Electrospun Fibrous Membrane Based on Metal–Organic Framework for Gradient Healing of Tendon‐to‐Bone Interface Regeneration
Authors: Yang Renhao , Zheng Yunlong , Zhang Yin , Li Gen , Xu Yidong , Zhang Yin , Xu Yang , Zhuang Chengyu , Yu Pei , Deng Lianfu , Cui Wenguo , Chen Yao , Wang Lei 
Published: March 2022

AbstractMetal ions play a significant role in tissue repair, with widely application in clinical treatment. However, the therapeutic effect of metal ions is always limited due to metabolization and narrow repair capability. Here, a bipolar metal flexible electrospun fibrous membrane based on a metal–organic framework (MOF), which is bioinspired by the gradient structure of the tendon‐to‐bone interface, with a combination of regulating osteoblasts differentiation and angiogenesis properties, is constructed successfully by a continuous electrospinning technique and matching the longitudinal space morphology for synchronous regeneration. Furthermore, the MOF, acting as carriers, can not only achieve the sustainable release of metal ions, but promote the osteogenesis and tenogenesis on the scaffold. The in vitro data show that this novel hierarchical structure can accelerate the tenogenesis, the biomineralization, and angiogenesis. Moreover, in the in vivo experiment, the flexible fibrous membrane can promote tendon and bone tissue repair, and fibrocartilage reconstruction, to realize the multiple tissue synchronous regeneration at the damaged tendon‐to‐bone interface. Altogether, this newly developed bipolar metal flexible electrospun fibrous membrane based on a MOF, as a new biomimetic flexible scaffold, has great potential in reconstruct the tissue damage, especially gradient tissue damage.
Spin–Phonon Coupling in Ferromagnetic Monolayer Chromium Tribromide
Authors: Wu Jiangbin , Yao Yu , Lin Miao‐Ling , Rösner Malte , Du Zhonghao , Watanabe Kenji , Taniguchi Takashi , Tan Ping‐Heng , Haas Stephan , Wang Han 
Published: March 2022

AbstractNovel 2D magnets exhibit intrinsic electrically tunable magnetism down to the monolayer limit, which has significant value for nonvolatile memory and emerging computing device applications. In these compounds, spin–phonon coupling (SPC) typically plays a crucial role in magnetic fluctuations, magnon dissipation, and ultimately establishing long‐range ferromagnetic order. However, a systematic understanding of SPC in 2D magnets that combines theory and experiment is still lacking. In this work, monolayer chromium tribromide is studied to investigate SPC in 2D magnets via Raman spectroscopy and first principle calculations. The experimental Curie temperature and phonon shifts are found to be in good agreement with the numerical simulations. Specifically, it is demonstrated how magnetic exchange interactions affect phonon vibrations, which helps establish design fundamentals for 2D magnetic materials and other related devices.
Piezoelectric Dynamics of Arterial Pulse for Wearable Continuous Blood Pressure Monitoring
Authors: Yi Zhiran , Liu Zhaoxu , Li Wenbo , Ruan Tao , Chen Xiang , Liu Jingquan , Yang Bin , Zhang Wenming 
Published: March 2022

AbstractPiezoelectric arterial pulse wave dynamics are traditionally considered to be similar to those of typical blood pressure waves. However, achieving accurate continuous blood pressure wave monitoring based on arterial pulse waves remains challenging, because the correlation between piezoelectric pulse waves and their related blood pressure waves is unclear. To address this, the correlation between piezoelectric pulse waves and blood pressure waves is first elucidated via theoretical, simulation, and experimental analysis of these dynamics. Based on this correlation, the authors develop a wireless wearable continuous blood pressure monitoring system, with better portability than conventional systems that are based on the pulse wave velocity between multiple sensors. They explore the feasibility of achieving wearable continuous blood pressure monitoring without motion artifacts, using a single piezoelectric sensor. These findings eliminate the controversy over the arterial pulse wave piezoelectric response, and can potentially be used to develop a portable wearable continuous blood pressure monitoring device for the early prevention and daily control of hypertension.
Shape‐Tuned Multiphoton‐Emitting InP Nanotetrapods
Authors: Kim Taehee , Kim Youngsik , Park Seongmin , Park Kyoungwon , Wang Zhen , Oh Sang Ho , Jeong Sohee , Kim Dongho 
Published: March 2022

AbstractAs the properties of a semiconductor material depend on the fate of the excitons, manipulating exciton behavior is the primary objective of nanomaterials. Although nanocrystals exhibit unusual excitonic characteristics owing to strong spatial confinement, studying the interactions between excitons in a single nanoparticle remains challenging due to the rapidly vanishing multiexciton species. Here, a platform for exciton tailoring using a straightforward strategy of shape‐tuning of single‐crystalline nanocrystals is presented. Spectroscopic and theoretical studies reveal a systematic transition of exciton confinement orientation from 3D to 2D, which is solely tuned by the geometric shape of material. Such a precise shape‐effect triggers a multiphoton emission in single nanotetrapods with arms longer than the exciton Bohr radius of material. In consequence, the unique interplay between the multiple quantum states allows a geometric modulation of the quantum‐confined Stark effect and nanocrystal memory effect in single nanotetrapods. These results provide a useful metric in designing nanomaterials for future photonic applications.
Plasmon‐Induced Disorder Engineering for Robust Optical Sensors
Authors: Shutsko Ivan , Buchmüller Maximilian , Meudt Maik , Görrn Patrick 
Published: March 2022

AbstractOptical metasurfaces address a plethora of applications in planar optics, as they enable precise control of the phase, amplitude, and polarization of light at nanoscale interaction lengths. However, their implementation requires surface nanostructuring, based on complex design and fabrication methods. In addition, exploiting narrow spectral features, e.g., for sensing, is accompanied by high demands in terms of precise post‐process alignments of probing light—impractical for compact optical systems. Here, the realization of plasmonic metasurfaces, based on silver nanoparticles (AgNPs) and using a solution‐based growth method, is demonstrated. The particle growth is mediated by localized surface plasmon resonances. The resulting nanostructures are directly applicable as self‐optimized metasurfaces in optical systems, as their fabrication and probing procedures allow the use of common—photonic and plasmonic—platforms. Information regarding the electromagnetic (EM) environment is stored during the fabrication via distinct particle positions and dimensions. The resulting optical response is inherently sensitive to deviations from this EM environment—enabling high‐performance nanoplasmonic sensing with a maximum discrete Figure of Merit* ( of 968 without the need for post‐process alignments.
Inorganic CsPbBr3 Perovskite Nanocrystals as Interfacial Ion Reservoirs to Stabilize FAPbI3 Perovskite for Efficient Photovoltaics
Authors: Chen Yuetian , Wei Ning , Miao Yanfeng , Chen Haoran , Ren Meng , Liu Xiaomin , Zhao Yixin 
Published: March 2022

AbstractBulk lead halide perovskite films with unique optoelectronic properties and facile low‐cost processing methods are promising for various optoelectronic applications including photovoltaics. Solution‐processed colloidal inorganic perovskite nanocrystals with higher crystallinity hold good potential for devices with better stability and optoelectronic properties. To address phase stability and defect passivation issues in black phase FAPbI3 perovskite, all‐inorganic perovskite CsPbBr3 nanocrystals (CPB NCs) are adapted as an effective modifier to form CPB NC‐treated FAPbI3 perovskite films (noted as CPB NC‐FAPbI3). It is identified in this study that, the incorporated CsPbBr3 NCs not only act as surface additives for the bulk perovskite films, but can also serve as ion reservoirs to supply both cation and halide exchanges at the interface. This two‐way ion exchange in CPB NC‐FAPbI3 samples leads to the formation of a compositional gradient as FA1−xCsxPbI3−yBry layers on the bulk perovskite film surface with vertically varied x and y values. Defects at interfaces and grain boundaries are therefore effectively passivated, leading to improved stability and charge carrier dynamics. As a result, the CPB NC‐FAPbI3 perovskite based solar cells exhibit overall enhancements in device efficiency and operational stability.
Promoting justice through community‐based research: International case studies
Authors: Suarez‐Balcazar Yolanda , Balcazar Fabricio , Miranda Daniela E. , Velazquez Tesania , Arcidiacono Caterina , Garcia‐Ramirez Manuel 
Published: March 2022

AbstractCommunity‐based participatory research (CBPR) approaches to promoting justice focus on working from the ground up and giving a voice to marginalized communities regarding their concerns, potential solutions, and how to address social justice issues that matter to them. The pursuit of justice is often related to efforts to attain personal as well as collective well‐being. In this paper, we illustrate three exemplars of community psychologists' efforts to promote justice. Within each case study, we discuss the social and community context and examine how the researchers built partnerships and solidarity, developed ways of doing, and approached challenges and solutions. First, we present an example to promote economic justice through an entrepreneurship initiative developed in collaboration with young Black youth with disabilities in the United States. The second case illustrates an effort to promote reproductive justice in collaboration with Roma women and girls in Spain. The third exemplar depicts the use of life stories as a method to raise the voices of displaced, marginalized indigenous women in Peru. Based on these three case studies, we present a synthesis model of social justice. We also discuss implications for future studies emphasizing the importance of engaging community participants in research meaningful ways, developing sustainable partnerships, and decolonizing research.
Coronavirus disease 2019 (COVID‐19)–related smell and taste impairment with widespread diffusion of severe acute respiratory syndrome–coronavirus‐2 (SARS‐CoV‐2) Omicron variant
Authors: Boscolo‐Rizzo Paolo , Tirelli Giancarlo , Meloni Pierluigi , Hopkins Claire , Madeddu Giordano , De Vito Andrea , Gardenal Nicoletta , Valentinotti Romina , Tofanelli Margherita , Borsetto Daniele , Lechien Jerome R. , Polesel Jerry , De Riu Giacomo , Vaira Luigi Angelo 
Published: March 2022

AbstractBackgroundThe aim of this study was to estimate the prevalence of self‐reported chemosensory dysfunction in a study cohort of subjects who developed a mild‐to‐moderate coronavirus disease 2019 (COVID‐19) in the period from January 17, 2022, to February 4, 2022 (Omicron proxy period) and compared that with a historical series of patients testing positive for severe acute respiratory syndrome–coronavirus‐2 (SARS‐CoV‐2) infection between March and April, 2020 (comparator period).MethodsProspective study based on the 22‐item Sino‐Nasal Outcome Tool (SNOT‐22), item “sense of smell or taste” and additional outcomes.ResultsPatients’ characteristics and clinical presentations of COVID‐19 were evaluated and compared in 779 patients, 338 of the study cohort and 441 of the historical series. The prevalence of self‐reported chemosensory dysfunction during the proxy Omicron period (32.5%; 95% confidence interval [CI], 27.6–37.8) was significantly lower from that during the comparator period (66.9%; 95% CI, 62.3–71.3) (p < 0.001). Nearly one‐quarter of patients (24.6%; 95% CI, 20.1–29.5) reported an altered sense of smell during the proxy Omicron period compared to 62.6% (95% CI, 57.9–67.1) during the comparator period (p < 0.001). Similarly, the prevalence of an altered sense of taste dropped to 26.9% (95% CI, 22.3–32.0) during the proxy Omicron period from 57.4% (95% CI, 52.6–62.0) during the comparator period (p < 0.001). The severity of chemosensory dysfunction was lower in the proxy Omicron period compared to the comparator period (p < 0.001).ConclusionThe prevalence and the severity of COVID‐19–associated smell and taste dysfunction has dropped significantly with the advent of the Omicron variant but it still remains above 30%.
Airway obstruction time and outcomes in patients with foreign body airway obstruction: multicenter observational choking investigation
Authors: Igarashi Yutaka , Norii Tatsuya , Sung‐Ho Kim , Nagata Shimpei , Yoshino Yudai , Hamaguchi Takuro , Nagaosa Riko , Nakao Shunichiro , Tagami Takashi , Yokobori Shoji 
Published: March 2022

AimForeign body airway obstruction (FBAO) is a major public health concern worldwide for infants and older adults. This study determines the association between airway obstruction time and neurological outcomes to plan an effective response for patients with FBAO.MethodsThis multicenter retrospective observational study was carried out among patients with life‐threatening FBAO in Japan over a period of 4 years. The duration of airway obstruction was calculated from the time of the accident to the time of foreign body removal. The study examined the relationship between airway obstruction time and outcome. The primary outcome was vegetative state or death at hospital discharge.ResultsAmong 119 patients, 68 were in the category of vegetative state or death. Logistic regression analysis showed that longer airway obstruction time (adjusted odds ratio 1.04; 95% confidence interval 1.01–1.07) was associated with vegetative state or death. When the cut‐off value was set at 10, the sensitivity was 0.88, the specificity 0.47, with the area under the curve 0.69. Using the other cut‐off value of 4 min, the negative predictive value was 1.00.ConclusionLonger airway obstruction time was associated with vegetative state or death for patients with FBAO. The incidence of vegetative state or death increased when the airway obstruction time exceeded 10 min. Meanwhile, 4 min or less may be set as a target time for foreign body removal in order to prevent vegetative state or death and plan an effective response.
Decreasing Multiple Sclerosis Treatment Expenditures and Improving Quality at the Health System Level
Authors: Langer‐Gould Annette , Cheng Stephen C. , Li Bonnie H. , Smith Jessica B. , Kanter Michael H. ,   for the Kaiser Permanente Southern California Multiple Sclerosis specialist group
Published: March 2022

ObjectiveThis study was undertaken to evaluate a multicomponent health system intervention designed to reduce escalating disease‐modifying treatment (DMT) expenditures and improve multiple sclerosis (MS) outcomes by increasing use of preferred formulary and highly effective DMTs (HETs).MethodsWe conducted a trend study of treatment utilization and expenditure outcomes prior to (2009–2011) and during (2012–2018) MS Treatment Optimization Program (MSTOP) implementation in Kaiser Permanente Southern California (KPSC) compared to a Kaiser Permanente region of similar size. Annual relapse rates (ARRs) were obtained from KPSC's electronic health records.ResultsAdherence to preferred formulary DMTs increased from 25.4% in 2011 to 72.2% in 2017 following MSTOP implementation in KPSC and 22.1% to 43.8%, respectively, in the comparator. KPSC's annual DMT expenditures in 2018 were less than in 2011 despite an 11.3% increase in DMT‐treated members. The decline in average per patient per year of treatment expenditures from a peak of $43.1 K in 2014 to $26.3 K in 2018 in KPSC was greater than the comparator, which peaked at $52.1 K and declined to $40.0 K in 2018. Over the 7 years following initiation of MSTOP, cumulative MS DMT expenditures were $161.6 million less than the comparator. HET use increased to 62.5% of per patient treatment‐years versus 32.4% in the comparator. This corresponded to a 69% decline in adjusted ARR (95% confidence interval = 64.1–73.2%;p < 0.0001) among DMT‐treated patients in KPSC.InterpretationA novel, expert‐led health system intervention reduced MS DMT expenditures despite rising prices while simultaneously reducing MS relapse rates. Our focus on health system progress toward meaningful, measurable targets could serve as a model to improve quality and affordability of MS care in other settings. ANN NEUROL 2022;92:164–172
Mesoionische Imine (MIIs): Starke Donoren und vielseitige Liganden für Übergangsmetalle und Hauptgruppensubstrate
Authors: Rudolf Richard , Neuman Nicolás I. , Walter Robert R. M. , Ringenberg Mark. R. , Sarkar Biprajit 
Published: March 2022

AbstractWir berichten über die Synthese und die Reaktivität mesoionischer Imine (MIIs) des 1,2,3‐Triazolin‐5‐imin Typs. Die MIIs sind über eine Basen‐mediierte Cycloaddition eines substituierten Acetonitrils mit einem aromatischen Azid, Methylierung nach etablierten Methylierungsrouten und anschließender Deprotonierung zugänglich. C=O‐Streckschwingungen in MII−CO2− und −Rh(CO)2Cl‐Komplexen wurden bemüht um die Gesamtdonorstärke zu bestimmen. Die MIIs sind stärkere Donoren als N‐Heterocyclische Imine (NHIs). MIIs sind exzellente Liganden für Hauptgruppenelemente und Übergangsmetalle, in welchen sie Substituenten‐induzierte Fluor‐spezifische Wechselwirkungen zeigen oder C−H‐Aktvierungen eingehen. DFT‐Berechnungen haben Einblicke in die Grenzorbitale der MIIs gegeben. Die Rechnungen sagen im Vergleich zu verwandten Liganden eine relative kleine HOMO–LUMO Lücke vorraus. MIIs können potentiell sowohl als π‐Donor‐ als auch π‐Akzeptorliganden wirken. Dieser Bericht demonstiert das Potential von MIIs spannende Eigenschaften mit einem gewaltigen Zukunftspotential zu entwickeln.
X‐ray Electron Density Study of the Chemical Bonding Origin of Glass Formation in Metal–Organic Frameworks**
Authors: Sarkar Sounak , Grønbech Thomas Bjørn Egede , Mamakhel Aref , Bondesgaard Martin , Sugimoto Kunihisa , Nishibori Eiji , Iversen Bo Brummerstedt 
Published: March 2022

AbstractGlass‐forming metal–organic frameworks (MOFs) have novel applications, but the origin of their peculiar melting behavior is unclear. Here, we report synchrotron X‐ray diffraction electron densities of two zeolitic imidazolate frameworks (ZIFs), the glass‐forming Zn‐ZIF‐zni and the isostructural thermally decomposing Co‐ZIF‐zni. Electron density analysis shows that the Zn−N bonds are more ionic than the Co−N bonds, which have distinct covalent features. Variable‐temperature Raman spectra reveal the onset of significant imidazolate bond weakening in Co‐ZIF‐zni above 673 K. Melting can be controlled by tuning the metal–ligand and imidazole bonding strength as shown from thermal analysis of nine solid‐solution CoxZn1−x‐ZIF‐zni (x=0.3 to 0.003) MOFs, and a mere 4 % Co‐doping into Zn‐ZIF‐zni results in thermal decomposition instead of melting. The present findings demonstrate the key role of the metal–ligand bonds and imidazolate bonds in controlling the delicate balance between melting and decomposition processes in this class of ZIF compounds.
Estimating Phosphorescent Emission Energies in IrIII Complexes Using Large‐Scale Quantum Computing Simulations**
Authors: Genin Scott N. , Ryabinkin Ilya G. , Paisley Nathan R. , Whelan Sarah O. , Helander Michael G. , Hudson Zachary M. 
Published: March 2022

AbstractHere we calculate T1→S0 transition energies in nine phosphorescent iridium complexes using the iterative qubit coupled cluster (iQCC) method to determine if quantum simulations have any advantages over classical methods. These simulations would require a gate‐based quantum computer with at least 72 fully‐connected logical qubits. Since such devices do not yet exist, we demonstrate the iQCC method using a purpose‐built quantum simulator on classical hardware. The results are compared to a selection of common DFT functionals, ab initio methods, and empirical data. iQCC is found to match the accuracy of the best DFT functionals, but with a better correlation coefficient, demonstrating that it is better at predicting the structure–property relationship. Results indicate that the iQCC method has the required accuracy to design organometallic complexes when deployed on emerging quantum hardware and sets an industrially relevant target for demonstrating quantum advantage.
Steering Self‐Assembly of Three‐Dimensional Iptycenes on Au(111) by Tuning Molecule‐Surface Interactions
Authors: Grossmann Lukas , Ringel Eva , Rastgoo‐Lahrood Atena , King Benjamin T. , Rosen Johanna , Heckl Wolfgang M. , Opris Dorina , Björk Jonas , Lackinger Markus 
Published: March 2022

AbstractSelf‐assembly of three‐dimensional molecules is scarcely studied on surfaces. Their modes of adsorption can exhibit far greater variability compared to (nearly) planar molecules that adsorb mostly flat on surfaces. This additional degree of freedom can have decisive consequences for the expression of intermolecular binding motifs, hence the formation of supramolecular structures. The determining molecule‐surface interactions can be widely tuned, thereby providing a new powerful lever for crystal engineering in two dimensions. Here, we study the self‐assembly of triptycene derivatives with anthracene blades on Au(111) by Scanning Tunneling Microscopy, Near Edge X‐ray Absorption Fine Structure and Density Functional Theory. The impact of molecule‐surface interactions was experimentally tested by comparing pristine with iodine‐passivated Au(111) surfaces. Thereby, we observed a fundamental change of the adsorption mode that triggered self‐assembly of an entirely different structure.