bluuebunny/crossref_metadata_2025_split huggingface dataset:
Antimicrobial use in Canadian acute-care hospitals: Findings from three national point-prevalence surveys between 2002 and 2017
Authors: Liang Jennifer J. , Rudnick Wallis , Mitchell Robyn , Brooks James , Bush Kathryn , Conly John , Ellison Jennifer , Frenette Charles , Johnston Lynn , Lavallée Christian , McGeer Allison , Mertz Dominik , Pelude Linda , Science Michelle , Simor Andrew , Smith Stephanie , Stagg Paula , Suh Kathryn N. , Thampi Nisha , Thirion Daniel J.G. , Vayalumkal Joseph , Wong Alice , Taylor Geoffrey ,   for the Canadian Nosocomial Infection Surveillance Program
Published: March 2022

AbstractObjectives:The Canadian Nosocomial Infection Surveillance Program conducted point-prevalence surveys in acute-care hospitals in 2002, 2009, and 2017 to identify trends in antimicrobial use.Methods:Eligible inpatients were identified from a 24-hour period in February of each survey year. Patients were eligible (1) if they were admitted for ≥48 hours or (2) if they had been admitted to the hospital within a month. Chart reviews were conducted. We calculated the prevalence of antimicrobial use as follows: patients receiving ≥1 antimicrobial during survey period per number of patients surveyed × 100%.Results:In each survey, 28−47 hospitals participated. In 2002, 2,460 (36.5%; 95% CI, 35.3%−37.6%) of 6,747 surveyed patients received ≥1 antimicrobial. In 2009, 3,566 (40.1%, 95% CI, 39.0%−41.1%) of 8,902 patients received ≥1 antimicrobial. In 2017, 3,936 (39.6%, 95% CI, 38.7%−40.6%) of 9,929 patients received ≥1 antimicrobial. Among patients who received ≥1 antimicrobial, penicillin use increased 36.8% between 2002 and 2017, and third-generation cephalosporin use increased from 13.9% to 18.1% (P < .0001). Between 2002 and 2017, fluoroquinolone use decreased from 25.7% to 16.3% (P < .0001) and clindamycin use decreased from 25.7% to 16.3% (P < .0001) among patients who received ≥1 antimicrobial. Aminoglycoside use decreased from 8.8% to 2.4% (P < .0001) and metronidazole use decreased from 18.1% to 9.4% (P < .0001). Carbapenem use increased from 3.9% in 2002 to 6.1% in 2009 (P < .0001) and increased by 4.8% between 2009 and 2017 (P = .60).Conclusions:The prevalence of antimicrobial use increased between 2002 and 2009 and then stabilized between 2009 and 2017. These data provide important information for antimicrobial stewardship programs.
An analysis of 90-day emergency department visits after peripherally inserted central catheter (PICC) placement for prosthetic joint infection
Authors: Charalambous Lefko T. , Hinton Zoe , Kim Billy I. , Case Ayden , Brown Meredith , Jiranek William , Seidelman Jessica , Bolognesi Michael P. , Seyler Thorsten M. 
Published: March 2022

AbstractObjective:Research on complications with peripherally inserted central catheter (PICC) lines that are placed for the treatment of prosthetic joint infection (PJI) after total hip arthroplasty (THA) and total knee arthroplasty (TKA) is scarce. We investigated the timing, frequency, and risk factors for PICC complications during treatment of PJI after THA and TKA.Methods:We retrospectively queried an institutional database for THA and TKA patients from January 2015 through December 2020 that developed a PJI and required PICC placement at an academic, tertiary-care referral center.Results:The study included 889 patients (48.3% female) with a mean age of 64.6 years (range, 18.7–95.2) who underwent 435 THAs and 454 TKAs that were revised for PJI. The cohort had 275 90-day ED visits (30.9%), and 51 (18.5%) were PICC related. The average time from discharge to PICC ED visit was 26.2 days (range, 0.3–89.4). The most common reasons for a 90-day ED visit were issues related to the joint replacement or wound site (musculoskeletal or MSK; n = 116, 42.2%) and PICC complaints (n = 51, 18.5%). A multivariable logistic regression demonstrated that non-White race (odds ratio [OR], 2.24; 95% confidence interval [CI], 1.24–4.04; P = .007) and younger age (OR, 0.98; 95% CI, 0.95–1.00; P = .035) were associated with PICC-related ED visits. Malposition/readjustment (41.2%) and occlusion (35.3%) were the most common PICC complications leading to ED presentation.Conclusions:PICC complications are common after PJI treatment, accounting for nearly 20% of 90-day ED visits.
Changes in body weight in response to pecan-enriched diets with and without substitution instructions: a randomised, controlled trial
Authors: Guarneiri Liana L. , Paton Chad M. , Cooper Jamie A. 
Published: March 2022

Abstract
Substantial evidence suggests that regular tree nut consumption does not lead to changes in body weight (BW). However, these studies used a variety of dietary substitution instructions which may confound the interpretation of prior BW outcomes. The purpose of the present study was to examine the impact of daily pecan consumption, with or without isocaloric substitution instructions, on BW and composition. This was an 8-week randomised, controlled trial with three treatments: a nut-free control group (n 32) and two pecan groups. ADD (n 30) consumed pecans (68 g/d) as part of a free-living diet, and SUB (n 31) substituted the pecans (68 g/d) for isocaloric foods from their habitual diet. BW and total body fat percentage (BF) were measured, and theoretical changes in these outcomes if pecans were consumed without compensation were determined. BW increased in all groups across the intervention, and there was a trend (P = 0⋅09) for an increase in ADD (1⋅1 ± 0⋅2 kg) and SUB (0⋅9 ± 0⋅3 kg) compared to control (0⋅3 ± 0⋅2 kg). In addition, there was increased BF in SUB (1⋅0 ± 0⋅3 %; P = 0⋅005) but not ADD (0⋅1 ± 0⋅2 %) or control (−0⋅2 ± 0⋅3 %) There was a large difference in the actual v. theoretical change in BW regardless of pecan treatment (actual: 1⋅1 ± 0⋅2 and 0⋅9 ± 0⋅3 v. theoretical: 3⋅3 ± 0⋅0 and 3⋅2 ± 0⋅0 kg in ADD and SUB, respectively; P < 0⋅001). Furthermore, there was a difference in actual v. theoretical change in BF in ADD (0⋅1 ± 0⋅2 v. 1⋅2 ± 0⋅1 %; P = 0⋅002) but not SUB or control. In conclusion, daily pecan consumption for 8 weeks did not result in significant weight gain, regardless of dietary substitution instructions.
Vaccine damage schemes in the US and UK reappraised: making them fit for purpose in the light of Covid-19
Authors: Goldberg Richard 
Published: March 2022

AbstractVaccines have continued to play a crucial global role in preventing infectious diseases in the twenty-first century. The Covid-19 pandemic has underlined their importance, with vaccines seen as the best way to protect the public from coronavirus. A longstanding problem of governments has been the extent to which they should assume responsibility for the compensation of those injured by vaccines. This paper reappraises the vaccine damage schemes currently available in the US and UK in the light of the Covid-19 pandemic. It argues that any improvements to both US and UK schemes should be included in a revised national vaccine policy which takes into consideration their respective long-term national vaccine strategies to prepare for future pandemics. It supports the adoption of a UK-wide National Vaccine Injury Compensation Programme, similar to the one in the US, to be administered by the Secretary of State for Health and Social Care. To balance the need for rigorous criteria to determine causation with the need for fairness, the programme should adopt the US practice of allowing negotiated settlements between parties in circumstances where review of the evidence has not concluded that the vaccine(s) caused the alleged injury but there are close calls concerning causation.
The return of children: a comparative study on the contemporary Turkish and Irish novel
Authors: Gürle Meltem 
Published: March 2022

AbstractIn Infancy and History Agamben (1993) suggests, following Benjamin’s footsteps, that true experience is only possible in infancy, a time that has not yet been expropriated by the bareness of modern life. The kind of potentiality that he attributes to infancy signifies the emergence of a new self, which, rather than moving into the mechanical domain of “work,” prefers to remain in the creative territory of “play,” where it is possible to transform old societal structures into new ones.Agamben’s approach to play and its non-chronological temporality offers useful clues in revealing the dynamics of the increasing number of contemporary childhood narratives in Irish and Turkish literature, where characters resist the linear structure of the bildungsroman and the corresponding model of progress, eventually forming a culture of adolescents resistant to maturity. Focusing on some common features of these novelistic characters, such as playfulness, self-experimentation, and messianic idealism, this paper argues that the return of children to contemporary Turkish and Irish novel opens a new terrain of possibilities that offer liberation from the poverty of experience Agamben attributes to modern society.
The impact of exercise and cumulative physical activity on energy intake and diet quality in adults enrolled in the Midwest Exercise Trial for the Prevention of Weight Regain
Authors: Ptomey Lauren T. , Montgomery Robert N. , Gorczyca Anna M. , Szabo-Reed Amanda N. , Sullivan Debra K. , Hastert Mary , Foster Rachel N.S. , Washburn Richard A. , Donnelly Joseph E. 
Published: March 2022

AbstractThe purpose of this study was to assess impact of different volumes of exercise as well as cumulative moderate to vigorous physical activity (MVPA) on energy intake (EI) and diet quality, as assessed by the Healthy Eating Index-2010(HEI-2010), across a 12-month weight maintenance intervention. Participants were asked to attend group behavioural sessions, eat a diet designed for weight maintenance and exercise either 150, 225 or 300 min/week. Dietary intake was assessed by 3-d food records, and MVPA was assessed by accelerometry. Two hundred and twenty-four participants (42·5 years of age, 82 % female) provided valid dietary data for at least one time point. There was no evidence of group differences in EI, total HEI-2010 score or any of the HEI-2010 component scores (all P > 0·05). After adjusting for age, sex, time, group and group-by-time interactions, there was an effect of cumulative MVPA on EI (1·08, P = 0·04), total HEI-2010 scores (–0·02, P = 0·003), Na (–0·006, P = 0·002) and empty energy scores (–0·007, P = 0·004. There was evidence of a small relationship between cumulative daily EI and weight (β: 0·00187, 95 % CI 0·001, P = 0·003). However, there was no evidence for a relationship between HEI total score (β: −0·006, 95 % CI 0·07, 0·06) or component scores (all P > 0·05) and change in weight across time. The results of this study suggest that increased cumulative MVPA is associated with clinically insignificant increases in EI and decreases in HEI.
n-3 PUFA can reduce IL-6 and TNF levels in patients with cancer
Authors: Guo Yongzhong , Ma Bo , Li Xinhua , Hui Hui , Zhou Yun , Li Na , Xie Xiaomei 
Published: March 2022

AbstractCurrent studies on inhibitory effects of n-3 PUFA on pro-inflammatory cytokines have inconsistent results. Thus, a meta-analysis of randomised controlled trials was conducted to identify the effects of n-3 PUFA administration on circulating IL-6 and TNF in patients with cancer. Studies that examined the effects of n-3 PUFA administration on circulating IL-6 and TNF in patients with cancer were identified by searching PubMed and EMBASE from January 1975 to February 2021. Differences in n-3 PUFA administration and control conditions were determined by calculating standardised mean differences (SMD) with 95 % CI. Twenty studies involving 971 patients met the inclusion criteria. The overall SMD were 0·485 (95 % CI 0·087, 0·883) for IL-6 and 0·712 (95 % CI 0·461, 0·962) for TNF between n-3 PUFA administration and control conditions. Sources of heterogeneity were not found through subgroup and meta-regression analyses. Publication bias was observed in TNF with a slight contribution to the effect size. n-3 PUFA can reduce circulating IL-6 and TNF levels in patients with cancer. Results supported the recommendation of n-3 PUFA as adjuvant therapy for patients with cancer, possibly excluding head and neck cancer, owing to their anti-inflammatory properties.
The First Global Revivalist? Reuben Archer Torrey and the 1902 Evangelistic Campaign in Australia
Authors: Treloar Geoffrey R. 
Published: March 2022

AbstractAs a revivalist who appeared to have initiated a world-wide awakening of Christianity and was also an early leader of the fundamentalist movement, Reuben A. Torrey is generally regarded as a major figure in the early twentieth-century history of evangelicalism. By tracing its origins and results, this article attributes Torrey's rise to prominence in the global evangelical movement to the evangelistic campaign he conducted in Australia in 1902. Setting this episode in the context of the history of international revivalism, it identifies Torrey as the first global revivalist in influence as well as geographical range. In place of the traditional providential interpretation, the analysis proposes the alignment of the revivalist theology, methods, and achievement exhibited in the Australian campaign with the hopes and expectations of the preexisting conservative evangelical subculture as a “functionalist” explanation of Torrey's impact. As the reason for Torrey's transformed standing in the evangelical movement in America and the wider world, the 1902 Australian campaign also emerges as a revealing case study of the dynamics of global evangelicalism and the function of international revivalism at the beginning of the twentieth century.
Interparental conflict and depressive symptoms among Chinese adolescents: A longitudinal moderated mediation model
Authors: Luo Rui , Chen Fumei , Ke Li , Wang Yun , Zhao Yunyan , Luo Yuhan 
Published: March 2022

AbstractWhile the detrimental effect of interparental conflict on adolescent depression is well-established, the underlying mechanisms linking the two continue to be inadequately understood. This study investigated the mediating role of family functioning and the moderating role of cultural beliefs about adversity in the association between interparental conflict and adolescent depression. The samples included 651 Chinese adolescents (mean age at Time 1 = 13.27 years; 56.5% girls) from a two-wave longitudinal study with data spanning 1 year. The findings from path modeling analyses provided evidence for the mediating role of family functioning; these findings indicated that interparental conflict can damage family functioning, which in turn exacerbates the risk of adolescent depression. The moderating role of cultural beliefs about adversity was also demonstrated by interactions between interparental conflict and cultural beliefs about adversity, as well as, family functioning and cultural beliefs about adversity. The results indicated a buffering role of cultural beliefs about adversity on the deleterious effect of interparental conflict on adolescent depression. They also suggested that lower levels of family functioning was associated with increased depression among adolescents were lower in cultural beliefs about adversity.
ARCH Project and the Global Initiatives of Disaster Health Management
Authors: Yanasan Alisa , Pongpamon Natthanicha , Pattanarattanamole Ratrawee , Rojsaengroeng Rapeeporn , Natsukawa Tomoaki , Katsube Tsukasa , Kubo Tatsuhiko , Toyokuni Yoshiki , Ikeda Shuichi 
Published: March 2022

AbstractObjective:The prime aim of Project for Strengthening the ASEAN Regional Capacity on Disaster Health Management (ARCH Project) is to strengthen the disaster health management (DHM) capacity in the context of personal level, Emergency Medical Team (EMT), and the regional collaboration. The ARCH Project was implemented with reference to international trends of DHM and seeks to contribute to the development of global standards.Methods:The project established the Project Working Groups that consisted of representatives of ASEAN Member States (AMS) to develop standard operating procedures (SOP) for international EMT (I-EMT) coordination. Furthermore, it aimed to organize training sessions along with implementation of the regional collaboration drill (RCD) in accordance with I-EMT minimum requirements and in line with coordination standards set by the WHO.Results:The ARCH Project developed the SOP and common platform for I-EMT coordination, organized training, and conducted RCDs with reference to the WHO’s EMT initiative. Furthermore, it also contributed to the development of the EMT Minimum Data Set (MDS), an international standard DHM tool that underwent testing at the RCDs before the WHO endorsement and its utilization in actual disaster response.Conclusion:In the process of strengthening ASEAN regional capacity in DHM, the project is constantly capturing international trends and also making significant contributions in the development of global systems and tools.
Integrated Differential Phase Contrast (IDPC)-STEM Utilizing a Multi-Sector Detector for Imaging Thick Samples
Authors: Li Zhongbo , Biskupek Johannes , Kaiser Ute , Rose Harald 
Published: March 2022

AbstractThe integrated differential phase contrast (IDPC) method is useful for generating the potential map of a thin sample. We evaluate theoretically the potential of IDPC imaging for thick samples by varying the focus at different sample thicknesses. Our calculations show that high defocus values result in enhanced anisotropy of the contrast transfer function (CTF) and uninterpretable images, if a quadrant detector is applied. We further show that applying a multi-sector detector can result in an almost isotropic CTF. By sector number-dependent calculations for both Cc/C3-corrected and C3-corrected scanning transmission electron microscopy (STEM), we show that the increase of detector sectors not only removes the anisotropy of the CTF, but also improves image contrast and resolution. For a proof-of-principle IDPC-STEM (uncorrected) experiment, we realize the functionality of a 12-sector detector from a physical quadrant detector and demonstrate the improvement in contrast and resolution on the example of InGaN/GaN quantum well structure.
The WTO in Crisis: Closing the Gap between Conversation and Action or Shutting Down the Conversation?
Authors: Low Patrick 
Published: March 2022

AbstractThe multilateral trading system faces numerous challenges that are more profound than at any time in its seven-decade history. It has become commonplace to ask whether the system is in terminal decline. More than a dozen issues facing the WTO are identified in the paper, eight of which are defined as systemic. That is because they permeate and debilitate multiple facets of the workings of the WTO, including the capacity to negotiate, enforce disciplines, monitor policies, and ensure transparency. In no prioritized order, systemic issues arise in the areas of dispute settlement, development, decision-making, transparency, relations between states and markets, subsidies, emerging issues including climate change and digitalization, and trade and health. Other outstanding issues may not be as pervasive in impact, but can nevertheless undermine WTO relevance and effectiveness. All WTO members stand to lose in the absence of predictable multilateral trade rules that pre-commit parties to certain policies and processes. But in today's world, full convergence of all trade rules is a pipe dream. The system needs to balance convergence with managed divergence. Does the non-discrimination principle need to be layered by prior agreement in ways that ensure mutual gains from exchange?
Letting the Music ‘Speak For Itself’? Dvořák as Strategist
Authors: Branda Eva 
Published: March 2022

‘I only write music and let it speak for itself’ – such was Antonín Dvořák's attitude, according to Josef Kovařík, the composer's personal secretary in New York. Indeed, throughout his career, Dvořák seemed reluctant to share his views publicly. He did not contribute articles to Czech periodicals, his acquaintances were well aware of his dread of making public appearances and speeches, and contemporary critics often commented on his humble and unenterprising nature.Yet Dvořák was not as passive as his alleged statement to Kovařík would imply. While visiting England during the 1880s, he became particularly concerned about forging a certain kind of image for himself in the Czech lands. Not only did Dvořák take an interest in English reviews of his music, he also sent several of these critiques to his contacts at home with the request that they be reprinted in Czech translation in the newspapers and journals of Prague. He proved to be equally strategic in some of his other professional choices, including the surprising decision to dedicate his patriotic cantata Hymnus: Heirs of the White Mountain ‘to the English people’, which can be understood as a clever tactical ploy, meant to signal the composer's international credentials to audiences at home.Drawing upon various letters and the many excerpted English reviews that appeared in the Czech press, this article shows that Dvořák played an active part in determining which aspects of his reception in England would be relayed to the Czech public. More broadly, the article examines Dvořák's role as strategist – an aspect of the composer's career that has remained largely unexplored. Ultimately, Dvořák was mindful of what Michael Beckerman calls ‘the public-relations aspect of nationalism’, and the suggestion that he was content simply to let the music ‘speak for itself’ does not tell the whole story.
The Limits of Indonesia and India Trade Cooperation: The Case of Import Tariffs on Refined Palm Oil 2019–2020
Authors: Karim Moch Faisal , Tiffani Claeri 
Published: March 2022

AbstractThis article examines limitations present in India–Indonesia bilateral trade relations. Since January 2019, India has imposed higher import tariffs on Indonesian refined, bleached, deodorised palm oil (RBDPO) than those imposed on Indonesia's main competitor Malaysia. This tariff policy weakened Indonesia's exports, given that India is Indonesia's third-largest export destination for palm oil. To overcome these tariff disparities, the Indonesian government responded with a trade-off strategy, offering to lower its import tariffs on India's raw sugar in exchange for a reduction in India's import tariffs on Indonesia's RBDPO. However, this strategy has thus far failed to generate a satisfying outcome for Indonesia. This article examines the obstacles in enacting such a strategy from the Indonesian perspective. By mobilising the concept of reluctance in international politics, this article argues that India's reluctance hinders Indonesia's trade-off strategy. This reluctance is evidenced by India's hesitation and recalcitrance, resulting in delays, and reversal of policy as well as ignoring Indonesian requests regarding the trade-off strategy. This could indicate that India does not prioritise Indonesia in its Indo-Pacific vision, particularly in enhancing cooperation with Southeast Asian nations, particularly Indonesia.