bluuebunny/crossref_metadata_2025_split huggingface dataset:
Geothermal renewable energy prospects of the African continent using GIS
Authors: Elbarbary Samah , Abdel Zaher Mohamed , Saibi Hakim , Fowler Abdel-Rahman , Saibi Kamal 
Published: May 2022

AbstractGeothermal energy potential is identified through the deep investigation of geological, geothermal, and geophysical information over a small area; however, this task is both expensive and complex. Geographic Information Systems (GIS) can integrate different types of data (or thematic layers) over large regions and use them to identify zones of high geothermal potential. In this study, we use GIS as a tool to construct the first regional-scale geothermal potential map of Africa from different datasets. The key objective of this study is to estimate the geothermally promising areas within Africa by integrating geological thematic layers (rock units and faults), geophysical layers (heat flow derived from aeromagnetic data and seismicity), and geothermal layers (hot springs and volcanoes) within the GIS database. A weighted overlay technique within the GIS environment is applied to these data to generate the geothermal potential map. The result shows 14 regions with a high geothermal favorability index. The geothermal potential map of Africa is useful for targeting and exploring new geothermal renewable energy sites and can reduce exploration costs and pinpoint investigation areas during preliminary geothermal studies.
The lateral joint line opening: a radiographic indicative parameter for high grade varus knees
Authors: Colyn William , Cleymans A. , Bruckers L. , Houben R. , Smeets K. , Bellemans J. 
Published: May 2022

Abstract
Purpose
It is usually assumed that the severity of varus osteoarthritis (OA) of the knee is correlated with the axis deviation of the limb. Despite this, there is currently no clear radiographic definition to define a so-called ‘high degree’ varus knee, which is characterized by a pronounced lateral ligamentous laxity. The purpose of this study was to radiographically determine if the lateral joint line opening (LJLO) is an indicative parameter when defining so-called high grade varus knees.

Methods
Two hundred forty Full length radiographs of patients with end-stage varus osteoarthritis who were scheduled for Total knee arthroplasty (TKA) were evaluated. The Hip-knee-ankle-angle (HKA-angle), Joint-line-convergence-angle (JLCA) and the lateral joint line opening were measured. The lateral joint line opening is the shortest distance between the lateral tibial plateau and the deepest point of the lateral femoral condyle. Linear regression models were used to investigate the relationships between the radiographic measurements.

Results
Hip-knee-angle-angle, joint-line-conversion-angle, and lateral joint line opening were all positively correlated (p < 0.001). An increase of 1 mm lateral joint line opening causes an increase of 0.6° joint-line-conversion-angle (p = 0.029) below a cut-off point of 4.7 mm. For lateral opening values beyond 4.7 mm, the gradient increased to 1.2 (p < 0.001). A lateral joint line opening of 4.7 mm corresponds to a hip-knee-ankle-angle of 6.0° (95% CI [5.5; 6.5]).

Conclusion
A lateral joint line opening of more than 5 mm in end-stage OA knees is indicative of increased lateral joint laxity. Those knees can be radiographically classified as so-called ‘high-grade’ varus knees.

Level of evidence
Therapeutic study, Level III.
Optimization of ethanol-extracted lignin from palm fiber by response surface methodology and preparation of activated carbon fiber for dehumidification
Authors: Fan Jie , Yu Qiongfen , Li Ming , Chen Jie , Wang Yunfeng , Zhang Ying , Li Guoliang , Ma Xun , Zhong Hao , Yu Yamei 
Published: May 2022

AbstractLignin is a renewable bioresource that can be used for a variety of value-added applications. However, the effective separation of lignin from lignocellulosic biomass remains an ongoing challenge. In this study, lignin was extracted from waste palm fiber and successfully converted into a dehumidifying material. The following four process parameters of lignin extraction from palm fiber were optimized systematically and comprehensively using the response surface methodology: reaction time, extraction temperature, ethanol concentration and solid/liquid ratio. The results revealed that under the optimum processing conditions (111 min of extraction at 174 °C using 73% ethanol at 1/16 g/mL solid/liquid ratio), the extraction yield of lignin was 56.2%. The recovery of ethanol solvent was as high as 91.8%. Further, the lignin could be directly used without purification to produce lignin-based activated carbon fibers (LACFs) with specific surface area and total pore volume of 1375 m2/g and 0.881 cm3/g, respectively. Compared with the commercial pitch-based activated carbon fiber, the LACF has a higher specific area and superior pore structure parameters. This work provides a feasible route for extracting lignin from natural palm fiber and demonstrates its use in the preparation of activated carbon fiber with a remarkable performance as a solid dehumidification agent.
Graphical Abstract
A multi-component reaction for covalent immobilization of lipases on amine-functionalized magnetic nanoparticles: production of biodiesel from waste cooking oil
Authors: Amini Yalda , Shahedi Mansour , Habibi Zohreh , Yousefi Maryam , Ashjari Maryam , Mohammadi Mehdi 
Published: May 2022

AbstractA new approach was used for the immobilization of Thermomyces lanuginosus lipase (TLL), Candida antarctica lipase B (CALB), and Rhizomucor miehei lipase (RML) on amine-functionalized magnetic nanoparticles (Fe3O4@SiO2-NH2) via a multi-component reaction route (using cyclohexyl isocyanide). The used method offered a single-step and very fast process for covalent attachment of the lipases under extremely mild reaction conditions (25 °C, water, and pH 7.0). Rapid and simple immobilization of 20 mg of RML, TLL, and CALB on 1 g of the support produced 100%, 98.5%, and 99.2% immobilization yields, respectively, after 2 h of incubation. The immobilized derivatives were then used for biodiesel production from waste cooking oil. Response surface methodology (RSM) in combination with central composite rotatable design (CCRD) was employed to evaluate and optimize the biodiesel production. The effect of some parameters such as catalyst amount, reaction temperature, methanol concentration, water content for TLL or water-adsorbent for RML and CALB, and ratio of t-butanol (wt%) were investigated on the fatty acid methyl esters (FAME) yield.
Graphical Abstract
Identifying tsunami traces beyond sandy tsunami deposits using terrigenous biomarkers: a case study of the 2011 Tohoku-oki tsunami in a coastal pine forest, northern Japan
Authors: Shinozaki Tetsuya , Sawai Yuki , Ikehara Minoru , Matsumoto Dan , Shimada Yumi , Tanigawa Koichiro , Tamura Toru 
Published: May 2022

AbstractThe distributions of sandy tsunami deposits do not reflect the true extents of tsunami inundation areas, leading to underestimates of inundation by past tsunamis and thus the magnitudes of their associated tsunamigenic earthquakes. To archive the sedimentological and geochemical features of the 2011 Tohoku-oki tsunami deposit, we performed visual observations and computed tomography, grain-size, water content, and organic geochemical analyses of sediments from a coastal forest at Oirase Town, northern Japan. Stratigraphic observations revealed the 2011 tsunami deposit to be a landward-thinning interbedded sand and soil layer that became ambiguous in landward locations. The sediment samples from the inundated area did not contain marine-sourced biomarkers; instead, peak concentrations of isolongifolene, an organic compound derived fromPinusin the forest, were observed within or just above the sandy tsunami deposits in sediment sections. Peak isolongifolene concentrations were also detected in landward soils inundated by the tsunami in which no sand layer was observable, but were not observed beyond the inundation limit. Although this characteristic biomarker is unique to this and similar depositional environments, these results suggest that lateral changes of the concentrations of environment-specific biological proxies in the sedimentary column may record tsunami inundation.
Post-colostomy internal hernia of the stomach treated with laparoscopic gastropexy: a case report
Authors: Tada Yoichiro , Orihara Junpei , Wada Yamato , Uchinaka Ei , Osaki Tomohiro , Ashida Keigo , Tatebe Shigeru , Kuroda Seika , Hirooka Yasuaki 
Published: May 2022

Abstract
Background
Internal hernias are formed by the protrusion of internal organs through an aperture formed congenitally or postoperatively. Internal hernias are most commonly associated with the small intestine. Only two cases of a post-sigmoid colostomy internal hernia of the stomach have been reported. This hernia arises from the space between the lifted sigmoid colon and the left abdominal wall. In the two aforementioned cases, treatment comprised suturing of the sigmoid colon to the lateral abdominal wall and changing of the intraperitoneal route to an extraperitoneal one. Herein, we present a very rare case who underwent laparoscopic gastropexy for a post-sigmoid colostomy internal hernia of the stomach.

Case presentation
Our patient, a 67-year-old woman, was undergoing chemoradiation for rectal cancer and planned to undergo abdominoperineal resection. However, tumor perforation resulted in a high fever and a right gluteal abscess; therefore, a sigmoid colostomy was performed through the intraperitoneal route in the left lower abdomen. One month after the surgery, the patient presented to our emergency room with vomiting, abdominal pain, and abdominal distension. Computed tomography revealed a markedly distended stomach caused by the obstruction of the pylorus secondary to the colostomy; laparoscopic gastropexy was performed subsequently and the postoperative course was uneventful.

Conclusions
This is the first report on the laparoscopic gastropexy treatment of a post-sigmoid colostomy internal hernia of the stomach; our findings may help physicians manage such hernias.
A case of severe sciatica caused by a lymphocele after renal transplantation
Authors: Yamada Naoto , Kumagai Motoi , Suzuki Kenji S 
Published: May 2022

Abstract
Background
Sciatica is commonly caused by lumbar spinal disease. However, it can also be caused by tumors, infectious diseases, or muscle entrapment. We present a case of sciatica caused by a lymphocele after renal transplantation.

Presentation
A 50-year-old man who had undergone renal transplantation presented with sciatica and low back pain without leg edema. The patient was diagnosed with lumbar disc herniation during the first medical examination. Regardless of the treatment, the symptoms were exacerbated and red flag signs of low back pain were observed. Compression of the sciatic nerve by the lymphocele was confirmed by computed tomography. The sciatica was improved by ethanol injection for the lymphocele.

Conclusions
We encountered a rare case of severe sciatica without edema caused by lymphocele after renal transplantation. Careful examination is required to make a different diagnosis of lymphocele from other lumbar spinal diseases.
Psychometric properties of the Chinese version of the trust between People and Automation Scale (TPAS) in Chinese adults
Authors: Cai Jie , Sun Qian , Mu Zeyue , Sun Xiaoning 
Published: May 2022

AbstractTrust in automation plays a leading role in human-automation interaction. As there lack of scales measuring trust in automation in China, the purpose of this study was to adapt the trust between People and Automation Scale (TPAS) into Chinese and to demonstrate its psychometric properties among Chinese adults. A total of 310 Chinese adults were randomly selected as sample 1, and 508 Chinese adults as sample 2. Results of the item analysis revealed that each item had a good quality, and the exploratory factor analysis (EFA) and confirmatory factor analysis (CFA) suggested that the two-factor model with 12 items was the best fitting model. In addition, the TPAS was positively correlated with Interpersonal Trust Scale (ITS), proving good evidence based on relations to other variables to support the TPAS. In sum, the study suggested that the Chinese version of the TPAS could be used as an effective tool to assess trust in automation in the Chinese context.
Perceptions and experiences of COVID-19 vaccines’ side effects among healthcare workers at an Egyptian University Hospital: a cross-sectional study
Authors: Orebi Hisham Ahmed , Emara Hesham Elsayed , Alhindi Abdallah Ahmoud , Shahin Mohamed Reda , Hegazy Arwa Hassan , Kabbash Ibrahim Ali , Saied Shimaa M. 
Published: May 2022

AbstractBackgroundA safe and effective vaccine is the ultimate key to mitigating the COVID-19 pandemic. Vaccine acceptance is influenced by various factors, including perceptions about the vaccine’s safety and side effects. The side effects vary depending on the type of the vaccine, but they are mainly mild, local, temporary, and self-limiting.MethodsA cross-sectional study was carried out at Tanta University Hospitals, including 1246 healthcare workers who received either the first or the second dose of the COVID-19 vaccine, selected via a systematic random sampling technique using a self-administered structured validated questionnaire for data collection from November 2021 to January 2022. Qualitative data were presented as frequencies and percentages and analyzed using Chi-square and Fisher’s exact tests.ResultsThe prevalence of one or more side effects was 91.3%. Among participants, about two-thirds believed in vaccine safety and its necessity (65.4% and 63.6%, respectively). Significantly more participants (46.9%) were concerned about AstraZeneca thrombotic complications than other vaccine types. The top five side effects reported by participants were injection site pain (64.8%), sense of fatigue (57.1%), headache (49.9%), muscle pain (48.7%), and fever (46.5). Most of the side effects were significantly higher among participants vaccinated with AstraZeneca. Side effects impacted work capacity of 23.4%, which was significantly higher among participants who received AstraZeneca (33.6%).ConclusionParticipants had a good level of belief in vaccination safety and necessity. Healthcare workers who got the AstraZeneca vaccination reported more adverse effects than other vaccines. Injection site pain, fatigue, headache, muscle pains, and fever were the most frequently reported side effects. More research on vaccination safety is needed to understand the long-term adverse effects of vaccinations better, improve the public trust, and accelerate vaccine adoption.
Strategies for precision vagus neuromodulation
Authors: Ahmed Umair , Chang Yao-Chuan , Zafeiropoulos Stefanos , Nassrallah Zeinab , Miller Larry , Zanos Stavros 
Published: May 2022

AbstractThe vagus nerve is involved in the autonomic regulation of physiological homeostasis, through vast innervation of cervical, thoracic and abdominal visceral organs. Stimulation of the vagus with bioelectronic devices represents a therapeutic opportunity for several disorders implicating the autonomic nervous system and affecting different organs. During clinical translation, vagus stimulation therapies may benefit from a precision medicine approach, in which stimulation accommodates individual variability due to nerve anatomy, nerve-electrode interface or disease state and aims at eliciting therapeutic effects in targeted organs, while minimally affecting non-targeted organs. In this review, we discuss the anatomical and physiological basis for precision neuromodulation of the vagus at the level of nerve fibers, fascicles, branches and innervated organs. We then discuss different strategies for precision vagus neuromodulation, including fascicle- or fiber-selective cervical vagus nerve stimulation, stimulation of vagal branches near the end-organs, and ultrasound stimulation of vagus terminals at the end-organs themselves. Finally, we summarize targets for vagus neuromodulation in neurological, cardiovascular and gastrointestinal disorders and suggest potential precision neuromodulation strategies that could form the basis for effective and safe therapies.
THC and CBD affect metabolic syndrome parameters including microbiome in mice fed high fat-cholesterol diet
Authors: Gorelick Jonathan , Assa-Glazer Tal , Zandani Gil , Altberg Anna , Sela Noa , Nyska Abraham , Madar Zecharia 
Published: May 2022

Abstract
Background
Nonalcoholic fatty liver disease (NAFLD) is associated with metabolic syndrome, which often includes obesity, diabetes, and dyslipidemia. Several studies in mice and humans have implicated the involvement of the gut microbiome in NAFLD. While cannabis and its phytocannabinoids may potentially be beneficial for treating metabolic disorders such as NAFLD, their effects on liver diseases and gut microbiota profile have yet to be addressed. In this study, we evaluated the therapeutic effects of the two major cannabinoids, delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD), on NAFLD progression.

Methods
NAFLD was induced by feeding mice a high fat-cholesterol diet (HFCD) for 6 weeks. During this period, the individual cannabinoids, THC or CBD, were added to the experimental diets at a concentration of 2.5 or 2.39 mg/kg. Profile of lipids, liver enzymes, glucose tolerance, and gene expression related to carbohydrate lipids metabolism and liver inflammation was analyzed. The effect of THC or CBD on microbiota composition in the gut was evaluated.

Results
While not alleviating hepatic steatosis, THC or CBD treatment influenced a number of parameters in the HFCD mouse model. CBD increased food intake, improved glucose tolerance, reduced some of the inflammatory response including TNFa and iNOS, and partially mitigated the microbiome dysbiosis observed in the HFCD fed mice. THC produced a much weaker response, only slightly reducing inflammatory-related gene expression and microbiome dysbiosis.

Conclusions
The results of this study indicate the potential therapeutic effects of individual phytocannabinoids are different from the effects of the cannabis plant possessing a mixture of compounds. While CBD may help ameliorate symptoms of NAFLD, THC alone may not be as effective. This disparity can putatively be explained based on changes in the gut microbiota.
Formulation and optimization of polymeric agglomerates of Bosentan monohydrate by crystallo-co-agglomeration technique
Authors: Varia Umang , Patel Azad , Katariya Hitesh , Detholia Krunal 
Published: May 2022

Abstract
Background
The polymeric spherical agglomerate of Bosentan monohydrate was prepared by crystallo-co-agglomeration technique, for enhancing the micrometric properties and solubility of the drug. The agglomerates were developed using two distinct solvents, DCM as a good solvent and bridging liquid and water as a weak solvent, respectively. Hydrophilic polymer like HPMC K100M is used as a hardening agent which gives mechanical strength to the agglomerates, and PEG6000 is used as a wetting agent. Other excipients like talc which was used as a size enhancer, and PVA was used as an emulsifier agent. The formulation was optimized by Box–Behnken design. The concentration of talc and PEG6000, as well as rotation speed, was considered as independent variables. The particle size, angle of repose, and % drug content were used as dependent variables to investigate the effect of independent variables on dependent variables. The spherical crystal agglomerates were subjected to various physicochemical evaluations.

Results
The results revealed that as the concentration of talc and PEG6000 increases, the sphericity and particle size of the agglomerates increase, and at a low agitation, speed agglomerates become more spherical and coarser, which is confirmed by FESEM. The characterization like FTIR confirms no interaction with excipients, while XRPD confirms the polymorphic changes, and gas chromatography (GC) confirms the concentration of residual organic solvents in PDE limits. The optimized formulation of SAs showed a good angle of repose which is 30.33 ± 0.35, and the % cumulative drug release at 20 min was 94.14 ± 0.628%. Finally, the FDTs of the optimized batch were prepared.

Conclusions
The comparison of the in vitro release study of pure drugs with agglomerates and fast dispersible tablets of agglomerates confirms the solubility improvement. Finally, it can be concluded that the polymorphic crystal agglomerates enhance the solubility and micrometric properties of Bosentan monohydrate.
Anticipating experimentation as the ‘the new normal’ through urban living labs 2.0: lessons learnt by JPI Urban Europe
Authors: Bylund Jonas , Riegler Johannes , Wrangsten Caroline 
Published: May 2022

AbstractUrban living labs (ULLs) can be an important way to approach multi-stakeholder co-creation with regard to urban transitions and transformations. They have become a common type of co-creative experimentation, offering the opportunity to research and innovate on a wide variety of challenges in everyday settings. They test hypotheses to create pathways for a transition to sustainable urbanisation. However, there is mounting concern from practice, innovators, and research that there is little systematic integration of practical outputs. Moreover, the question of how ULLs should be designed, and by whom, requires comparative longer-term assessment. Implementation and operation requires knowledge of the risks involved. The long-term impacts of ULLs on particular places, and the general understanding of how they contribute to urban transformations, are not well theorized. Thus, intended and potential contributions to urban transformations could remain unrealized. Based on experience from a series of stakeholder dialogues and co-production formats at various ULL related conferences and workshop, this paper offers policy recommendations and directions regarding the future direction for JPI Urban Europe its main programme for 2021–2027, the European Partnership Driving Urban Transitions to a Sustainable Future in the Horizon Europe Framework Programme. It may also help other urban research and innovation funders and programming actors support sustainable transformations through urban living labs.