bluuebunny/crossref_metadata_2025_split huggingface dataset:
Modeling and Simulation of the Effect of Scan Strategy on Spatter Movement in Laser Powder Bed Fusion
Authors: Cen Weihong , Liu Yangzhong , Yan Honghao , Zhou Zirong , Zhou Zhukun , Shang Xin , Chen Shenggui , Long Yu 
Published: July 2022

Abstract

Multi-laser powder layer bed fusion (M-LPBF) has wide application prospects in aerospace, biomedical and industrial fields, dramatially improving the efficency of LPBF. However, the spatter still weakens the quality of the built part. With different scanning strategies, spatter distributed in various printing locations may result in compromised processing. By far, in existing spatter models, spatters are assumed as fixed particle size or multiple fixed injection angles, which do not adapt well to the spatter injection from the melt pool. Therefore, spatter injection models with three different particles with 300 in 28µm, 500 in 55µm and 1300 in 114µm, three different initial velocities and three angle ranges are developed to simulate with gas flow under six different scanning strategies. In gas-solid coupling simulation, the spatter injection model as discrete phase and N2 as continuous phase are calculated through passing information together. Particles ejection are in line with the spatter observed by others with high speed camera. It shows that particles with average particles with 63 in 28µm, 116 in 55µm and 398 in 114µm desiposit on the base, respectively. Its removal rates out of base are 79.0%, 76.8% and 69.4%, respectively. Besides, particles in 114µm deposit more on the start side of the scanning tracks under the scanning strategy of perpendicular to gas flow than others. Most particles deposit closer to the oulet with counter gas flow. The result will provide an important reference value for M-LPBF in the way of optimizing scanning strategy to reduce the impact of spatters.
White tea extract modified green synthesis of magnetite supported Ag nanoparticles: evaluation of its catalytic activity, antioxidant and anti-colon cancer effects
Authors: Hou De-Zhi , Ling Ping , Zhu Yu , Ouyang Yi-Ming , Karmakar Bikash 
Published: July 2022

Abstract

Herein, we have demonstrated an eco-friendly procedure for the synthesis of White tea plant extract modified and Ag nanoparticles (NPs) fabricated magnetic nanocomposite (Fe3O4@W.tea/Ag). The plant derived phytochemicals acted as bio-reductant and stabilizer in situ. The resulting nanocomposite was characterized by various analytical methods like FESEM, EDX, TEM, VSM, XRD, and ICP-AES analysis. The as-synthesized bio-nanomaterial was used as an excellent heterogeneous and magnetically retrievable catalyst in the three-component condensation of 4-hydroxycoumarin, malononitrile and various aldehydes in refluxing aqueous media. The material was easily magnetically retrievable and recycled for 8 successive times without significant loss in catalytic activity. After the chemical applications we also explored the material biologically in the resistance of human colon cancer and thereby studied the cytotoxicity over two standard cell lines, HT-29 and Caco-2. The conventional MTT assay was carried out over them which revealed an increase in % cell viability dose dependently. The IC50 values observed in the two cell lines were 384.2 μg/ml and 254.6 μg/ml respectively. In addition, DPPH radical scavenging test was performed for studying anti-oxidant activity, using BHT as the positive control. The results validate the administration of Fe3O4@W.tea/Ag nanocomposite as a competent colon protective drug in the clinical trial studies over human.
Suppression or aggression: Qualitative investigation of emotion expression among Iranian female adolescents.
Authors: Aghatabay Rabea , Vaezi Aliakbar , Rahimi Mehdi , Mahmoodabad Seyed Saeed Mazloomy , Fallahzadeh Hosein , Alizadeh Somayeh 
Published: July 2022

Abstract
Objectives: Emotion expression is a critical element of adaptive emotion regulation and is positively related to psychosocial well-being. This study was conducted following another cross-sectional study by the researchers which revealed that in female adolescents in Yazd, Iran, the expression of emotions is weak. The aim of this study was to learn more about barriers to expressing emotions in female adolescent students, from their point of view, in Yazd. Design: Data were collected using two focused-group discussions, as well as six individual interviews. Results: The theme “barriers to expressing emotions in the proper ways” was obtained from the data which consisted of three categories including lack of skills, lack of knowledge and planning, and wrong attitudes. Lack of skills comprises two subcategories; “aggression due to poor communication skills” and “silence due to weakness of assertiveness skills”. Similarly, wrong attitudes encompass two subcategories; “aggression due to wrong attitudes” and “silence due to wrong attitudes”. Conclusion: The results of the present study can provide researchers and policy makers with a useful guide for development of effective interventions to promote proper emotion expression in female adolescents.
Real time PCR for confirmation of host genes expression obtained from Microarray data analysis in Herpes Simplex Virus type 6-infected human whole blood cells obtained from children under five years in Tehran province, Iran
Authors: Chenari Maryam , Rezaie Farhad , Foroushani Abbas Rahimi , Mozhgani Sayed-Hamidreza , Parhizgari Najme , Saburi Azam , Mokhtariazad Talat 
Published: July 2022

Abstract
HHV-6 virus belongs to the Beta herpes family and is a major cause of Exanthema Subitum or Roseola with high fever in children under three years old. It can cross the blood-brain barrier for this reason 15% of children develop acute febrile seizures during the febrile phase. Investigation pathogenesis of this virus in febrile patients such as the most important genes cellular pathways and main cellular pathways can be complete information on the diagnostic also therapeutic methods of the virus. For this purpose, after obtaining 11 genes with up-regulation expression important role related fever mediated HHV-6 by Microarray DNA analysis in GSE40396, we compared the expression of these genes in HHV-6 positive patients to the healthy control group.Material and MethodHHV-6 DNA was investigated in 100 whole blood samples in children under five years by Nested PCR in 2 rounds, RNA was extracted from HHV-6 positive samples, Syber green Real-Time PCR on 12 cDNA samples from patients and normal groups was conducted, and results analyzed by GraphPad prism and SPSS software.ResultThe hypothetical model shows 11 genes including AIM2, ZBP1, CASP5, GSDMD, GBP1, IL-1b, IL-18, IL-33, IFN-a, IFN-B, IRF7 are interacted with each other and in the path leading to HHV-6-induced fever. In this study, the expression of these genes showed that all of these genes except GBP1 were overexpressed. The results of molecular and statistical tests also showed that the prevalence of acute HHV-6 infection in whole blood samples from children under five in Iran is 15% with an average of ten months. ConclusionMacrophages play an important role in the development of HHV-6 fever and its mechanism through communication with PGE2. This model shows only the signaling pathways and important genes involved in the development of fever. expression of AIM-2, IL-1B, IL-33, and IRF-7 genes increased significantly following HHV-6 infection.
Design and Analysis of Low Power FINFET SRAM with Leakage Current Reduction Techniques
Authors: Chandra K.Sarath , Kishore Kakarla Hari 
Published: July 2022

Abstract
This article provides the development and examination of low-power FINFET SRAM with leakage current reduction techniques. The CMOS properties do not hold up well at lesser technology nodes due to scalability. Investigators are seeking alternatives to counteract the negative impacts of MOSFET scalability, and FINFET has been proven to be one of the ideal alternatives since it preserves less energy, removes short-channel effects, and minimizes leakage current. Since the number of portable gadgets that run on batteries has expanded dramatically, electronic items must be built to require minimal leakage power such that the gadget may run for extended periods of time. Initially, a 6t CMOS SRAM was designed and calculated for all the parameters. Later, DGFINFET SRAM was designed, and it can be observed that, compared with the CMOS-based design, the dynamic power dissipated by the FinFET-based 6T cell is reduced by 1.6 times, but it has equivalent static power dissipation. That is, the FinFET based 6T cell design significantly consumes less power than the conventional design. Also, it has 18% better hold SNM and 26% better RSNM, but its write SNM is 19% less than the CMOS 6T cell, showing that the FinFET based design has feeble writing ability. As a result, the FINFET SRAM was examined using various leakage current reduction strategies, resulting in a decrease in leakage current. Various leakage current minimization strategies are examined in order to minimize leaking current, and the suggested technique is shown to be the optimum for the development of low leakage current minimization that results in lower power leakage.
Dexmedetomidine and the Combination of Benzodiazepine and Fentanyl in Elective Endovacular Stenting of the Coronary Arteries. Comparative Analysis
Authors: Tsarkov A. V. , Levit A. L. 
Published: July 2022

The optimal method of anesthetic management in percutaneous coronary interventions (PCI) is procedural analgosedation that in most cases is provided by the combination of benzodiazepine and an opioid analgesic. However, there are no protocols and recommendations for its implementation at this time.The objective: to choose an adequate and safe method of analgosedation for elective endovascular stenting of coronary arteries.Subjects and Methods. A randomized study was conducted from September 2021 to January 2022. The group where analgosedation with fentanyl and sibazon was used included 33 patients. 30 patients were enrolled in the group of analgosedation with dexmedetomidine. A comparison was made in terms of the level of sedation (RASS scale), hemodynamic parameters, blood oxygen saturation (SpO2), the incidence of anginal pain at the stage of stenting and the need for additional analgesia, and the level of serum troponin T.Results. Dexmedetomidine significantly induces a deeper level of sedation (RASS -2) compared to the combination of benzodiazepine and fentanyl (RASS -1) at the stage of intracoronary stent placement (p < 0.001). In the group of analgosedation with dexmedetomidine, there was a statistically significant decrease in blood pressure and heart rate versus the group of analgosedation with fentanyl and sibazon (p < 0.05). Analgesia with narcotic analgesics was required 9.1 times lower (p =0.028) at the stage of installation of intracoronary stents in the group of dexmedetomidine analgosedation versus the group of fentanyl and sibazon analgosedation (OR 0.11; 95% CI 0.13–0.92).Conclusion. Anesthesia for elective percutaneous coronary interventions with dexmedetomidine may be more adequate and safer than the combination of a benzodiazepine and an opioid analgesic. At the stage of coronary artery stenting, dexmedetomidine provides deeper sedation, significant prevention of the development of anginal pain, a pronounced hypotensive and negative chronotropic effect compared to analgosedation with fentanyl and sibazon.
Using the posterior TAP block for postoperative analgesia for major liver surgery in pediatrics
Authors: Bespalov E. K. , Zaitsev A. Yu. , Novikov D. I. , Dubrovin K. V. , Filin A. V. 
Published: July 2022

Anesthesiological provision of pediatric liver surgery is associated with problems related to perioperative analgesia. Standard methods of anesthesia can have contraindications and complications.The objective: To evaluate the safety and efficacy of the posterior TAP block for postoperative analgesia in pediatric liver surgery.Subjects and Methods. A prospective, single, blind, placebo-controlled pilot study was conducted. The participants were children aged 2 to 7 who underwent liver resection. The patients were divided into groups. In Control Group, combined anesthesia was performed. In Study Group, it was combined with a bilateral posterior TAP block. Pain in the postoperative period was assessed by the FLACC scale.Results. The intensity of pain in the postoperative period was higher in Control Group. More patients required tramadol administration in Control Group. There was no difference in the occurrence of the PONV syndrome. No complications associated with the block were noted.Conclusion. The posterior TAP block has a clinically significant analgesic effect and can be used for perioperative pain relief during pediatric liver surgery. This method is relatively safe. Impaired hemostasis system is not an absolute contraindication to a TAP block.
THE INFLUENCE OF LIQUIDITY, PROFITABILITY, SOLVENCY AND STOCK PRICES ON STOCK LIQUIDITY LQ 45
Authors: Juwita Anita , Pratama Putu Aditya 
Published: July 2022

This research to determine the effect of liquidity, profitability, solvency and stock prices on stock liquidity of LQ45 for companies listed at the Indonesia Stock Exchange period 2013-2020. The research method uses a quantitative approach and the population were all LQ45 companies listed at the BEI period 2013-2020. The sampling method using non-probability sampling with purposive sampling technique. This study using secondary data of financial statements and analysis technique using panel data regression model Eviews 10. The results showed that liquidity and solvability not affect on stock liquidity of LQ45 companies. Profitability has a positive and significantly effect on stock liquidity of LQ45 companies and stock prices have negative and significantly effect on stock liquidity of LQ45 companies.
A New Approach to Developing the Quality of Yoghurts with Functional Ingredients
Authors: Dunchenko Nina , Yankovskaya Valentina 
Published: July 2022

Only high-quality products are competitive, and competitive products have to meet all kinds of requirements, from regulatory documentation to consumer expectations. Functional foods, such as yogurt, are designed with targeted properties, which is a complex task that requires a methodologically universal approach. The research objective was to develop and test a new approach to developing the targeted properties in functional yoghurts.
The research featured a new technology and formulation of functional yogurt with sea buckthorn and cryopowdered germinated rye. The study involved qualimetric forecasting methodology, as well as standard quality assessment tools and methods.
The new approach included several stages: 1) identifying requirements for product quality and production processes, 2) analyzing discrepancy reports, 3) predicting the effect of quality-forming factors, and 4) developing universal solutions to ensure the required properties. The research resulted in a nomenclature of consumer expectation indicators and a comprehensive assessment formula. It revealed the reasons behind the poor quality of yogurt at different stages. The key requirements for yoghurt included: 1) high moisture-binding capacity, 2) natural functional ingredients that give the product high consumer properties and reduce the risk of microbiological spoilage. The article introduces a formulation and production technology for the new functional yogurt, which proved to have a high content of vitamin C, potassium, and β-carotene. The sensory evaluation demonstrated its high consumer properties.
The new approach to the development and production technology proved to be effective. It can be used in the design and quality control of yoghurts with functional ingredients.
Deficit irrigation with wastewater in direct sowed silage maize reduces CO2 emissions from soil by providing carbon savings
Authors: Yerli Caner , Sahin Ustun , Kiziloglu Fatih Mehmet , Oztas Taskin , Ors Selda 
Published: July 2022

AbstractDirect sowing and deficit irrigation practices can reduce the effect of wastewater on CO2 emissions from soil by providing carbon savings. Therefore, the effect of domestic recycled wastewater uses at different levels in irrigation under conventional tillage and direct sowing practices on the CO2 emission from soil at the end of the vegetation period of silage maize was investigated by comparing it with full irrigation of fresh water. Both organic carbon and CO2 emissions in the second year in fully irrigated treatments were higher than those in the first year. The CO2 emission in the full irrigation with wastewater (0.263 g m−2 h−1), compared to full irrigation with fresh water and 33 and 67% deficit irrigations with wastewater, was higher at 23.4, 25.0, and 59.3%, respectively. Direct sowing practice also (0.193 g m−2 h−1) resulted in 17.0% less CO2 emissions compared to conventional tillage. The positive linear relationships of H2O emission and the soil moisture content at different depths (5, 10, and 20 cm) with CO2 emission were significant, and the negative relationships with the soil temperatures were also found. It has been concluded that deficit irrigation and direct sowing applications can be practical for reducing CO2 emissions from soil in wastewater irrigation conditions.
Benzoxazine: A Privileged Scaffold in Medicinal Chemistry
Authors: Tang Zilong , Tan Yuhuan , Chen Hongjuan , Wan Yichao 
Published: July 2022

Background:
Benzoxazine is one of the most important privileged scaffolds in medicinal chemistry. Compounds bearing benzoxazine moiety usually have a variety of biological activities, such as anti-inflammatory, anti-microbial, anti-tuberculosis, anti-oxidant and anti-cancer activities. The fascinating bioactivity profile of benzoxazine scaffold in various fields has prompted medicinal chemists to design and discover novel benzoxazine derivatives as potential therapeutic candidates with the desired biological properties.

Objective:
This review aimed to provide a comprehensive elucidation on the recent advances of benzoxazine derivatives in medicinal chemistry.

Method:
We have searched the recent literatures about benzoxazine derivatives from the online resources and databases, such as pubmed, scifinder and google scholar.

Conclusion:
Benzoxazine is a versatile structure and building block in medicinal chemistry. Benzoxazine derivatives have gained considerable attention from medicinal chemists due to their various pharmacological properties and multiple modification sites. This review might help medicinal chemists to seek for new drug candidates with better bioactivities and pharmacokinetics properties.
Expression of MCMs in Endometrial Cancer and its Biological Correlation
Analysis
Authors: Guo Ruixia , Zhen Yu , Fu Hanlin , Si Lulu , Lai Tianjiao , Chu Danxia 
Published: July 2022

Purpose:
Minichromosome maintenance (MCM) has been demonstrated to be involved
in tumorigenesis and pathogenesis of many cancer types. However, the role of MCMs in endometrial
cancer (EC) has not been elucidated.

Materials and Methods:
We first employed GEPIA, cBioPortal, and R software to perform the differential
expression analysis, survival analysis, and gene alteration analysis of the MCMs family.
Then, GSE17025 and GSE63678 datasets and CTPAC were used to verify the mRNA and protein
expression levels of MCM4. In addition, the internal mechanism of the MCM4 was investigated by
comparing MCM4 expression-correlated differentially expressed genes (DEGs) from GEPIA and
MCM4-interacted genes from STRING. Last, Gene Ontology and Kyoto Encyclopedia of Genes
and Genomes (KEGG) pathway analyses were performed to identify MCM4-related biological
processes.

Results:
Compared with normal tissues, only MCM2 and MCM4 expression were significantly upregulated
in EC tissues. High expression of MCM4 was related to worse clinicopathological features
and poor prognosis in EC cohorts. Additionally, a certain degree of gene alterations in the
MCM2-7 gene was observed. By comparing MCM4 expression-correlated DEGs and MCM4-
interacted genes, six genes were obtained: SSRP1, ORC1, GINS1, CDK2, DBF4 and GINS3.
Functional enrichment analysis suggested that MCM4 may be involved in regulating the biological
processes of DNA replication and the p53 signaling pathway.

Conclusion:
This was the first comprehensive study to disclose the biological effects of MCMs in
EC, indicating that MCM4 could be used as a new prognostic biomarker and potential therapeutic
target for EC.
Stapled Surgery for Hemorrhoidal Prolapse: From the Beginning to Modern Times
Authors: Sturiale Alessandro , Fabiani Bernardina , Menconi Claudia , Cafaro Danilo , Celedon Porzio Felipe , Naldini Gabriele 
Published: July 2022

Introduction:
Hemorrhoidal disease is the most common proctologic condition in
adults. Among the different surgical procedures, one of the greatest innovations is represented by
the stapled hemorrhoidopexy. The history of this technique started with a single stapler use passing
through a double stapler technique to resect the adequate amount of prolapse, finally coming to the
use of high volume devices.

Methods:
Nevertheless, each device has its own specific feature, the stapler is basically made up
with one or more circular lines of titanium staples whose height may be variable. The procedure is
based on different steps: Introduction of the CAD, evaluation of the prolapse, fashioning purse
string or parachute suture, the introduction of the stapler head beyond the suture, pull the wires
through the window, close the stapler and keep pulled the wires of the suture held together with forceps,
fire using two hands, open the stapler and remove it and check the staple line and then check
the specimen. One of the latest innovations in stapled surgery is Tissue Selective Therapy. It is a
minimally invasive procedure in which there is a partial circular stapled hemorrhoidopexy focused
on the prolapsing piles with bridges of normal mucosa left.

Results:
Several studies have reported that SH is a safe and effective procedure to treat hemorrhoidal
prolapse. It is a quicker procedure with a shorter hospital stay and earlier return to work if compared
with the conventional treatment. This is due to less postoperative pain, postoperative bleeding,
wound complications and constipation. Furthermore, the first generation devices had worse
outcomes if compared with those of the new generation stapler that showed lower postoperative
complication rates with better anatomical and symptomatic results.

Conclusions:
Stapled procedure for the treatment of symptomatic hemorrhoidal prolapse represents
one of the most important innovations in proctology of the last century bringing with it the new revolutionary
concept of the rectal intussusception as a determining factor involved in the natural history
of the disease. Stapled hemorrhoidopexy marked an era in which the surgeon may offer the patients
a safe, effective treatment with less pain and fast recovery.