bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identification of prognostic alternative splicing signature in gastric cancer
Authors: Wang Zhiwu , Wu Qiong , Liu Yankun , Li Qingke , Li Jingwu 
Published: May 2022

Abstract
Background
Aberrant alternative splicing (AS) events could be viewed as prognostic indicators in a large number of malignancies. This study aims to identify prognostic AS events, illuminate the function of the splicing variants biomarkers and provide reliable evidence for formulating public health strategies for gastric cancer (GC) surveillance.

Methods
RNA-Seq data, clinical information and percent spliced in (PSI) values were available in The cancer genome atlas (TCGA) and TCGA SpliceSeq data portal. A three-step regression method was conducted to identify prognostic AS events and construct multi-AS-based signatures. The associations between prognostic AS events and splicing factors were also investigated.

Results
We identified a total of 1,318 survival-related AS events in GC, parent genes of which were implicated in numerous oncogenic pathways. The final prognostic signatures stratified by seven types of AS events or not stratified performed well in risk prediction for GC patients. Moreover, five signatures based on AA, AD, AT, ES and RI events function as independent prognostic indicators after multivariate adjustment of other clinical variables. Splicing network also showed marked correlation between the expression of splicing factors and PSI value of AS events in GC patients.

Conclusion
Our findings provide a landscape of AS events and regulatory network in GC, indicating that AS events might serve as prognostic biomarkers and therapeutic targets for GC.
Evaluating the retro-auricular incision versus reversed question mark incision and Kempe's 'T-bar' incision for decompressive hemicraniectomy
Authors: Eltabl Mohamed Ahmed , Ammar Ahmed Shawki , Saif Dalia Salah 
Published: May 2022

Abstract
Background
The proper decompression for hemicraniectomy depends on intraoperative surgical technique, so the skin incision, on the other hand, is an important variable throughout hemicraniectomy, and there are a variety of cutaneous incisions, including the Kempe T shaped, the reversed question mark and the retro-auricular incisions. We aim to compare those three types of incisions and assess their effects on the surgical outcomes regarding the skull defect size, survived beyond 1 week, post-operative complications and mortality rates.

Results
A retrospective study included 180 patients were separated into three age- and sex-matched groups according to the type of incision used for their hemicraniectomy. Data including age, sex, causes of surgery, comorbidities, the incision type, the defect area of the skull, intraoperative time and estimated blood loss were recruited for all patients. The mortality and morbidity rates at 3 months post-surgery were documented for all patients. There was a significant difference in the operative time, and the intraoperative measures of blood loss, and insignificant differences in the surviving rate after 1-week post-surgery among the three group patients. There were significant differences between the first and third patient groups compared to the second group regarding wound complications, while the first and third groups were comparable.

Conclusions
The retro-auricular incision is a safe preferable substitute for the reversed question mark and Kempe T-shaped incisions in decompressive hemicraniectomy, due to the better blood flow maintaining, lower rate of post-operative wound complications.
A bibliometric analysis of the cannabis and cannabinoid research literature
Authors: Ng Jeremy Y. , Chang Nathan 
Published: May 2022

AbstractBackgroundCannabis refers to a plant in the family Cannabaceae, which has been used medically, recreationally, and industrially. The last two decades, in particular, have seen a large increase in the volume of literature on this topic. The present bibliometric analysis aims to capture the characteristics of scholarly journal publications on the topic of cannabis and cannabinoid research.MethodsSearches were run on the Scopus database on April 02, 2021, as follows “(TITLE (cannabi* OR hashish OR marijuana OR marihuana)) AND ( LIMIT-TO ( DOCTYPE,"ar" ) OR LIMIT-TO ( DOCTYPE,"re" ) )”. Results were exported on the same day to prevent discrepancies between daily database updates. Only “article” and “review” publication types were included; no further search limits were applied. The “article” publication type includes publications featuring original research, whereas “review” includes reviews and conference papers. The following data were collected: number of publications (in total and per year), authors, and journals; open access status; publications per journal; journals publishing the highest volume of literature and their impact factors, language of publication; document type; publication country; author affiliations; funding sponsors; most highly cited publications; and most highly published authors. Trends in this subset of publications were identified and presented. Bibliometric networks were constructed using the software tool VOSviewer.ResultsA total of 29 802 publications (10 214 open access), published by 65 109 authors, were published in 5474 journals from 1829 to 2021. The greatest number of publications was published over the last 20 years. The journal that published the largest number of publications was Drug and Alcohol Dependence (n= 705). The most productive countries included the USA (n= 12 420), the UK (n= 2236), and Canada (n= 2062); many of the most common institutional affiliations and funding sponsors originated from these countries.ConclusionsThe number of publications published on the topic of cannabis follows an upward trend. Over the past 20 years, the volume of cannabis research has grown steeply, which can be attributed to a large amount of funding dedicated to researching this topic. Future research should continue to investigate changes in the publication characteristics of emerging research, as the volume of publications on this topic is expected to rapidly grow.
2D magnetotelluric inversion using hybrid stabilizing functionals: Exponential minimum support and smoothness
Authors: Song Han , Yu Peng , Wang Cheng , Zhang Luolei , Zhao Chongjin , Shi Bo , Hu Ming 
Published: May 2022

Except for producing smoothing models, magnetotelluric inversion also requires focused inversion, which can image sharp boundaries and clear interfaces of electrical structures. The proposed minimum support (MS) and minimum gradient support (MGS) have good focusing ability; however, their focusing effect is highly dependent on the selection of the focusing parameter. For finding a more stable way to achieve a well-focused image, we have developed an exponential minimum support (EMS) stabilizing functional, which combines the properties of the exponential stabilizer and MS, and determined the enhanced focusing ability and smaller dependence on the magnitude of the focusing parameter. Moreover, we construct a model constraint with the hybrid stabilizing functionals EMS and the smoothest (SM) and fulfill the optimization based on Occam’s inversion scheme. Through theoretical analysis and model tests, we determine the selection schemes of the regularization parameter, weighting parameter between EMS and SM, and focusing coefficient in EMS to ensure the stability and reliability of this method. Afterward, we perform the inversions of the synthetic and field data. By comparing the inversion results of the two synthetic wedge models using hybrid EMS and SM and those obtained using other stabilizers, we determine that the hybrid method is capable of imaging sharp boundaries and is stable for a wide range of focusing parameter values. The inversion result of the COPROD2 field data set clearly images the high-conductivity anomalies at depths of 10–60 km and also depicts the highly conductive features within the upper mantle at depths greater than 100 km. The model tests and field data application verify the stability and capability of this method. Thus, this novel regularization approach provides a tool for sharp boundary inversion and a new reference model for deep structural interpretation.
Prior Involvement of Central Motor Drive Does Not Impact Performance and Neuromuscular Fatigue in a Subsequent Endurance Task
Authors: LAGINESTRA FABIO GIUSEPPE , CAVICCHIA ALESSANDRO , VANEGAS-LOPEZ JENNIFER E. , BARBI CHIARA , MARTIGNON CAMILLA , GIURIATO GAIA , PEDRINOLLA ANNA , AMANN MARKUS , HUREAU THOMAS J. , VENTURELLI MASSIMO 
Published: May 2022

ABSTRACT

Purpose
This study evaluated whether central motor drive during fatiguing exercise plays a role in determining performance and the development of neuromuscular fatigue during a subsequent endurance task.

Methods
On separate days, 10 males completed three constant-load (80% peak power output), single-leg knee-extension trials to task failure in a randomized fashion. One trial was performed without preexisting quadriceps fatigue (CON), and two trials were performed with preexisting quadriceps fatigue induced either by voluntary (VOL; involving central motor drive) or electrically evoked (EVO; without central motor drive) quadriceps contractions (~20% maximal voluntary contraction (MVC)). Neuromuscular fatigue was assessed via pre–post changes in MVC, voluntary activation (VA), and quadriceps potentiated twitch force (Q
tw,pot). Cardiorespiratory responses and rating of perceived exertion were also collected throughout the sessions. The two prefatiguing protocols were matched for peripheral fatigue and stopped when Q
tw,pot declined by ~35%.

Results
Time to exhaustion was shorter in EVO (4.3 ± 1.3 min) and VOL (4.7 ± 1.5 min) compared with CON (10.8 ± 3.6 min, P < 0.01) with no difference between EVO and VOL. ΔMVC (EVO: −47% ± 8%, VOL: −45% ± 8%, CON: −53% ± 8%), ΔQ
tw,pot (EVO: −65% ± 7%, VOL: −59% ± 14%, CON: −64% ± 9%), and ΔVA (EVO: −9% ± 7%, VOL: −8% ± 5%, CON: −7% ± 5%) at the end of the dynamic task were not different between conditions (all P > 0.05). Compared with EVO (10.6 ± 1.7) and CON (6.8 ± 0.8), rating of perceived exertion was higher (P = 0.05) at the beginning of VOL (12.2 ± 1.0).

Conclusions
These results suggest that central motor drive involvement during prior exercise plays a negligible role on the subsequent endurance performance. Therefore, our findings indicate that peripheral fatigue–mediated impairments are the primary determinants of high-intensity single-leg endurance performance.
Factors contributing to under-reporting of patient safety incidents in Indonesia: leaders’ perspectives
Authors: Dhamanti Inge , Leggat Sandra , Barraclough Simon , Rachman Taufik 
Published: May 2022

Background: Understanding the causes of patient safety incidents is essential for improving patient safety; therefore, reporting and analysis of these incidents is a key imperative. Despite its implemention more than 15 years ago, the institutionalization of incident reporting in Indonesian hospitals is far from satisfactory. The aim of this study was to analyze the factors responsible for under-reporting of patient safety incidents in Indonesian public hospitals from the perspectives of leaders of hospitals, government departments, and independent institutions. Methods: A qualitative research methodology was adopted for this study using semi-structured interviews of key informants. 25 participants working at nine organizations (government departments, independent institutions, and public hospitals) were interviewed. The interview transcripts were analyzed using a deductive analytic approach. Nvivo 10 was used to for data processing prior to thematic analysis. Results: The key factors contributing to the under-reporting of patient safety incidents were categorized as hospital related and nonhospital related (government or independent agency). The hospital-related factors were: lack of understanding, knowledge, and responsibility for reporting; lack of leadership and institutional culture of reporting incidents; perception of reporting as an additional burden. The nonhospital-related factors were: lack of feedback and training; lack of confidentiality mechanisms in the system; absence of policy safeguards to prevent any punitive measures against the reporting hospital; lack of leadership. Conclusion: Our study identified factors contributing to the under-reporting of patient safety incidents in Indonesia. The lack of government support and absence of political will to improve patient safety incident reporting appear to be the root causes of under-reporting. Our findings call for concerted efforts involving government, independent agencies, hospitals, and other stakeholders for instituting reforms in the patient safety incident reporting system.
Demographic and socioeconomic predictors of religious/spiritual beliefs and behaviours in a prospective cohort study (ALSPAC) in Southwest England: Results from the parental generation
Authors: Major-Smith Daniel , Morgan Jimmy , Halstead Isaac , Tohidinik Hamid Reza , Iles-Caven Yasmin , Golding Jean , Northstone Kate 
Published: May 2022

Background: We explored associations between possible demographic and socioeconomic causes of religious/spiritual beliefs and behaviours (RSBB) in the parental generation of the Avon Longitudinal Study of Parents and Children (ALSPAC). Methods: We used a prospective birth cohort study (ALSPAC) in Southwest England with 14,157 enrolled mothers and 14,154 associated partners. Three RSBB outcome measures collected during pregnancy were examined: religious belief (belief in God/a divine power; yes/not sure/no), religious affiliation (Christian/none/other) and religious attendance (frequency of attendance at a place of worship). Multiple demographic and socioeconomic exposures were assessed (23 in mothers and 22 in partners). We explored age-adjusted associations between each exposure and outcome using multinomial regression, in addition to exposure-age interactions. Results: Many demographic and socioeconomic factors were associated with RSBB outcomes, including age, ethnicity, marital status, education, income and deprivation. Overall, higher socioeconomic position was associated with increased levels of RSBB, particularly regarding religious attendance. For instance, compared to mothers with the lowest level of educational attainment, a degree-level education was associated with six-fold increase in the relative risk ratio of religious attendance at least once a week, relative to not attending at all (RRR=5.90; 95% CI=[4.44; 7.86]). The magnitude of these associations often varied by outcome, e.g., income was associated with religious attendance, but not religious affiliation. Although results were demographically and socially patterned, overall effect sizes were relatively small, with a largest pseudo-R2 value of 2.4%. Patterns of association were similar for both mothers and partners. Conclusion: These findings demonstrate that numerous demographic and socioeconomic factors are associated with RSBB in this population. While additional work is needed to assess whether any of these associations are causal, this descriptive paper can help inform future studies using this data by considering appropriate confounders and thus attempt to minimise bias that confounding may introduce.
The frequency of significant relationships of selected features describing feet with the torso features among youth aged 7-13
Authors: Mrozkowiak Mirosław 
Published: May 2022

Introduction. Research on the relationships and co-occurrence of the feet and torso features in a group of 4-6-year-old children showed that the values of the left foot features show a significantly more frequent relationship with the features of the torso than the right foot features.
Material and method. The research was carried out in the group of adolescents aged 7 to 13 and registered 12,898 observations of the value of 90 features describing torso and feet. The working stand for measuring the features of body posture and feet using the photogrammetric method consists of a computer and a card, a programme, a monitor, a printer, and a projection-receiving device with a camera for measuring selected features.
Conclusions

A similar number of features of the right and left foot is often associated with the torso features. The following features like width of the feet, the angle of the 5thhallux valgus and the left foot big toe, the heel angle and height of the right foot second arch, the height of the second longitudinal arch and the length of the left foot, and the length of the first arch of the right foot show especially frequent relationships.
The feet features show the most frequent significant relationship with the torso features of the frontal plane, whereas less of sagittal plane and occasionally of transversal plane. Torso features, which the most common features of the feet are significantly related to are the height and length of lumbar lordosis, the height of thoracic kyphosis, the angle of the torso flexion in the sagittal plane, the length of the thoracic kyphosis, the bent angle of the thoracic-lumbar spine, the depth of thoracic kyphosis, the depth of lumbar lordosis, and the inclination angle of the upper thoracic segment of the spine. The features of the feet are whereby most frequently related to the features of lumbar lordosis.
Assistência em HIV/AIDS na Atenção Básica no Semiárido nordestino
Authors: Fernandes Sâmara Fontes , Soares Themis Cristina Mesquita , Silva Maria Rocineide Ferreira da , Gomes José Giovani Nobre , Freitas Rodrigo Jácob Moreira de , Silva Richardson Augusto Rosendo da 
Published: May 2022

Objetiva-se descrever a atuação da atenção básica na assistência a pessoas vivendo com HIV/Aids em uma região de saúde do Rio Grande do Norte. Este trabalho consiste em uma pesquisa descritiva, realizada no semiárido do Rio Grande do Norte (RN), especificamente na VI Região de Saúde. Tem como participantes da pesquisa os profissionais de saúde da Atenção básica de 13 municípios da região. Como instrumento de coleta de dados foi utilizado um questionário contendo 47 questões, os quais foram organizados em três domínios: 1-Acolhimento; 2-Diagnóstico; 3-Manejo clínico, analisados a partir de estatística descritiva e aprovado pelo CEP-UERN sob parecer: 2.567.260. A partir do estudo constatou-se que a assistência direcionada a pessoas que vivem com Hiv nesta região encontra-se fragilizada, com uma atenção básica pouco estruturada e com forte dependência dos serviços de alta complexidade situados nas grandes cidades do estado.
Users' perception about primary care attributes in a Metropolitan Region of Minas Gerais
Authors: Oliveira Graziella Lage , Xavier César Coelho , Ribeiro Adalgisa Peixoto , Proietti Fernando Augusto 
Published: May 2022

ABSTRACT
Introduction: Family Health Strategy (FHS) is a tool for Primary Health Care (PHC) consolidation in Brazil, coexisting with the Traditional Health model (THS). Aim: To evaluate PHC attributes, from the user's perspective, according to PHC models in Vespasiano, Brazil. Methods: A population-based cross-sectional study carried out between 2015-2016 with home users registered in the HIPERDIA Program, using the Primary Care Assessment Tool (PCATOOL). Descriptive and comparative analyzes were performed according to PHC models. Results: 1,227 adults participated in the study. Almost all the attributes evaluated showed inadequate orientation to PHC, except the Coordination. The FHS model obtained a better evaluation when compared to the THS model (p-value <0.05). Conclusions: Users' perception of PHC was unsatisfactory in practically all dimensions/attributes, with a slightly more positive evaluation for the FHS model. Greater attention must be paid to the contact and recognition of community’s needs by PHC health professionals.

RESUMO
Introdução: A Estratégia Saúde da Família (ESF) é um instrumento para consolidação da Atenção Primária à Saúde (APS) no Brasil, coexistindo com o modelo tradicional. Objetivo: Avaliar os atributos da APS, na perspectiva do usuário, segundo modelos de APS em Vespasiano, Brasil. Métodos: Estudo transversal de base populacional realizado entre 2015-2016 com usuários domiciliares e cadastrados no Programa HIPERDIA, utilizando o Primary Care Assessment Tool (PCATOOL). Análises descritivas e comparativas foram realizadas segundo os modelos de APS. Resultados: Participaram do estudo 1.227 adultos, cuja avaliação mostrou inadequada orientação dos serviços para a APS, exceto para o atributo Coordenação. O modelo ESF obteve melhor avaliação quando comparado ao modelo tradicional (p-valor<0,05). Conclusões: A percepção dos usuários foi insatisfatória para praticamente todos os atributos, sendo mais positiva para o modelo da ESF. Maior atenção deve ser dada ao contato e reconhecimento das necessidades da comunidade pelos profissionais de saúde da APS.
Когда и почему мигранты приобретают жилье в России и как это связано с интеграцией?
Authors: Варшавер Евгений Александрович , Иванова Наталия Сергеевна , Рочева Анна Леонидовна 
Published: May 2022

Статья отвечает на вопросы о том, когда и почему закавказские и среднеазиатские мигранты приобретают жилье в России и как приобретение жилья связано с интеграцией. Основной тестируемой моделью является теория линейной ассимиляции, дополненная резидентным компонентом. Эмпирическая база исследования — массовый всероссийский опрос в социальных сетях (N=4888), проведенный по анкете, посвященной связи резидентных и интеграционных переменных. Авторы используют корреляционно-регрессионный анализ, зависимой переменной выступает факт наличия недвижимости в собственности у респондента или одного из членов его семьи. В число независимых переменных включены по-разному сконструированные показатели интеграции. Согласно полученным результатам, хотя есть статистически значимая связь между большинством резидентных, интеграционных и прочих переменных, и все они связаны со временем, прошедшим с момента первой поездки в Россию, именно длительность присутствия в стране в первую очередь объясняет факт покупки жилья. Если принять во внимание этот фактор, большинство интеграционных переменных оказывается не связано с покупкой жилья. Содержательный вывод состоит в том, что даже если из показателей интеграции покупка жилья не следует, она может состояться по факту того, что мигрант давно в России. Эти результаты показывают, что для России в части резидентного поведения мигрантов в целом релевантна теория линейной ассимиляции с дополнениями, внесенными в нее транснациональной моделью.
Благодарность. Статья подготовлена при поддержке гранта Российского научного фонда (проект РНФ № 18-78-10086) «Анализ механизмов формирования этномиграционных анклавов в российских городах».
Методика прогнозирования результатов выборов с использованием комбинирования методов аналитического и трендового моделирования
Authors: Воробьев Андрей Анатольевич , Ноздрачева Екатерина Дмитриевна 
Published: May 2022

Работа посвящена исследованию возможностей прогнозирования рейтинга политических партий на коротких временных рядах с помощью данных социологических опросов ВЦИОМ по выборной тематике. Рассмотрены три основные группы методов: трендовое моделирование, экспертные оценки, аналитическое моделирование.
В результате теоретического анализа и проведенных экспериментов выявлена низкая точность прогнозов, полученных только с помощью методов, относящихся к группе трендового моделирования. Поэтому предложена методика, позволяющая повысить точность прогнозирования за счет корректировки полученных в результате логарифмической аппроксимации прогнозов. С помощью иерархической кластеризации находится вектор значений, состоящий из коэффициентов уравнений аппроксимации и описывающий наиболее «похожую» электоральную ситуацию в прошлом. Затем «остаток», вычисленный как разница суммы прогнозных значений и 100%, пропорционально перераспределяется в соответствии с участниками избирательной кампании. Для прогнозирования рейтинга партий, где значения временного ряда не превышают 5%, предпочтительнее применять метод среднего темпа роста.