bluuebunny/crossref_metadata_2025_split huggingface dataset:
Long-term analysis of сanagliflozin budget impact in adult patients with type 2 diabetes mellitus and diabetic nephropathy in the Russian Federation
Authors: Avxentyev N. A. , Makarova Yu. V. 
Published: October 2022

Background. Diabetic nephropathy (DN) is a specific kidney lesion in patients with diabetes mellitus, which leads to the development of endstage kidney disease and requires substitutive renal therapy (dialysis or transplantation). Canagliflozin is a sodium-glucose co-transporter 2 (SGLT2) inhibitor, which exerts a renoprotective effect. According to the published data, the application of canagliflozin in patients with type 2 diabetes mellitus (DM2) and DN could postpone dialysis therapy for almost 13 years.Objective: to perform a long-term analysis of canagliflozin budget impact in adult patients with DM2 and DN from the point of view of the constituent entities of the Russian Federation.Material and methods. A group of comparison for canagliflozin was placebo (no renoprotective pharmacotherapy). The authors proposed a mathematical model for DN progression in groups of patients who received canagliflozin (100 mg orally, daily, long-term) or placebo. The model was based on the extrapolation of the CREDENCE study data. The model was used for the analysis of the direct costs on the lifetime pharmacotherapy and dialysis per one patient. Epidemiologic data from the federal register on the number of adult patients with DM and DN prevalence among these patients were used to evaluate the size of the target population. Based on the clinical recommendations and the medical care standards for patients with DM and the data on the actual state procurement of SGLT2 inhibitors and glucagon-like peptide-1 receptor agonists in 2021, we evaluated the share of patients with DM2+DN who currently do not receive renoprotective therapy but who must be supplied with canagliflozin according to the standards. Among this population, we determined the patients with the glomerular filtration rate within 30–90 ml/min/1.73 m2, which provides the comparability of the target population with patients included in CREDENCE clinical study.Results. Direct medical costs per one patient receiving canagliflozin therapy were 678 108 rubles, which was 52.8% (759,239 rubles) lower than without renoprotective pharmacotherapy (1,437,347 rubles). As a result, considering the modeling period and current practice, the budget costs for pharmacotherapy of patients with DM2+DN were 99.82 billion rubles, in comparison with the proposed practice, which was 47.09 billion rubles (difference in budget costs is 52.73 billion rubles, or 52.8%). The accumulated costs of the regional health care system were lower in patients receiving canagliflozin in comparison with patients without renoprotective pharmacotherapy 11 years after the beginning of treatment.Conclusion. The expansion of canagliflozin application in the therapy for patients with DM2+DN leads to the budget cost cuts in the long run due to the extension of the dialysis-free period.
Mitigating Power and Memory Constraints on a Venusian Seismometer
Authors: Tian Yuan , Herrick Robert R. , West Michael E. , Kremic Tibor 
Published: October 2022

Abstract
The nearest term pathway to the deployment of a seismometer on Venus is an instrument that can operate under ambient surface conditions on battery power. We conduct a series of studies on combined hardware and software approaches to maximize the quality of data returned under the likely restrictions of minimal on-board data storage and only being able to transmit in real time during a small fraction of a multimonth deployment. We assess likely Venus seismicity by examining different terrestrial analog settings; we find that likely Venus analog settings all fall within about an order of magnitude of mean Earth in terms of seismicity level. We use the seismic record from a station in central Alaska as a Venus surrogate for algorithm development. We tested various transmission triggers and developed a simple low-memory algorithm that mimics the common terrestrial long-term average/short-term average trigger. If the seismometer can operate in coordination with an orbiter that can remotely turn off data transmission, then the frequency content of a few seconds of data can be used to distinguish small, nearby earthquakes from large, distal ones, and total data transmission can be tuned to favor the latter. If an orbiter can also turn on transmission for other nearby seismometers, it would further enhance the ability to distinguish small- and large-magnitude earthquakes autonomously and increase the chances of capturing the initial onset of significant events.
Deformation and quaternary faulting in southeast Missouri across the Commerce geophysical lineament
Authors: Stephenson W. J. , Odum J. K. , Williams R. A. , Pratt T. L. , Harrison R. W. , Hoffman D. 
Published: October 2022

AbstractHigh-resolution seismic-reflection data acquired at three sites along the surface projection of the Commerce geophysical lineament in southeast Missouri reveal a complex history of post-Cretaceous faulting that has continued into the Quaternary. Near Qulin, Missouri, approximately 20 m of apparent vertical fault displacement has occurred in the Quaternary. Reflection data collected at Idalia Hill, about 45 km to the northeast, reveal a series of reverse and possibly right-lateral strike-slip faults with Quaternary displacement. In the Benton Hills, 45 km northeast of Idalia Hill, seismic data image a complicated series of anticlinal and synclinal fault-bounded blocks immediately north of the Commerce fault. We infer that most of the deformation imaged in the upper 400 m of these three data sets occurred since post-Cretaceous time, and a significant portion of it occurred during Quaternary time. Collectively, these seismic data along with geomorphic and surface-geologic evidence suggest (1) the existence of at least one potential seismogenic structure in southeastern Missouri outside the main zones of New Madrid seismicity, and (2) these structures have been active during the Quaternary. The geographic location of the imaged deformation suggests it is related to structures along with the Commerce geophysical lineament.
Deconvolution of teleseismic body waves for enhancing structure beneath a seismometer array
Authors: Li Xiao-Qing , Nábělek John L. 
Published: October 2022

Abstract
We discuss three stacking deconvolution techniques for enhancing signal of Earth structure contained in the seismograms of teleseismic body waves recorded by a seismometer array. The goal of the deconvolution is to remove from the seismograms the complications due to the source. For three-component data, the removal of the source can be efficiently achieved by deconvolving one component from another, as in the receiver function analysis. In the case of an array, if the structure beneath individual stations varies, the source wavelet can be estimated and removed from the seismograms by stacking. This allows structural analysis in the situations when only single-component seismometers are used or when a particular component can provide additional independent information. Here we compare the efficacy of conventional time-domain stacking, cepstral averaging, and autocorrelation stacking. The latter is a new approach developed here. For cepstral averaging, we present conditions that stabilize the convergence. Examples are presented using synthetics and real data from a broadband seismic array experiment conducted in the Cascadia subduction zone (Oregon) in 1993 to 1994. Data from subduction zones are particularly well suited because of the spatially rapidly varying structure. We find that all three methods work well for low frequencies, which are not sensitive to the time alignment of the seismic traces. The latter two methods do not require precisely aligned seismograms, and their advantage becomes evident at higher frequencies where the appropriate time alignment is harder to achieve. At high frequencies, time-domain stacking is likely to fail.
Outlier detection from a mixture distribution when training data are unlabeled
Authors: Sain Stephan R. , Gray H. L. , Woodward Wayne A. , Fisk Mark D. 
Published: October 2022

AbstractWe consider the difficult task of using seismic signals (or any other discriminants) for detecting nuclear explosions from the large number of background signals such as earthquakes and mining blasts. Given a ground-truth database (i.e., labeled data), Fisk et al. (1996) consider the problem of detecting outliers (nuclear explosions) from a single background-signal population, and their approach has been applied successfully in several regions around the world. Wang et al. (1997) attack the problem in terms of modeling the background as a mixture distribution and looking for outliers (nuclear events) from that mixture. However, those authors only considered the case in which at least some fraction of the training sample was labeled, that is, at least some ground-truth information was available, and the number of distinct classes of events was known. In the current article, we extend these results to the case in which no events in the training sample are labeled and also to the case in which the number of event types represented in the training sample is unknown. One can view the mixture approach as a robust method for fitting a density to training data that may not be normally distributed whether or not the data consist of identifiable components that have a physical interpretation. The technique is demonstrated using simulated data as well as two sets of seismic data.
Personalized rehabilitation of patients after COVID-19: the experience of the Republic of Mari El
Authors: Khamitov R. F. , Soboleva E. A. 
Published: October 2022

Two years after the onset of the COVID-19 pandemic, not only the diagnosis and treatment, but also rehabilitation of patients at different times after the disease became relevant.The aim. To develop and analyze the efficiency of personalized hospital-based rehabilitation programs for COVID-19 patients.Methods. Retrospective analysis of medical records of 109 patients with COVID-19 admitted to the rehabilitation department. A team of physiotherapist, pulmonologist and psychiatrist used simulators (bicycle ergometer, treadmill, motomed, and stepper), physiotherapeutic exercises, training of respiratory muscles with Threshold IMT (Philips, Netherlands) simulators, psychotherapy, and physiotherapy.Results. A total of 109 patients, 59 (54%) men and 50 (46%) women, aged 56.54 ± 11.73 уears suffered from moderate (41%), severe (40%) and very severe (19%) COVID-19. 25% of the patients had concomitant diabetes mellitus, 65% – arterial hypertension, and 22% – ischemic heart disease. Patients with 5 rehabilitation points (5RP) on Rehabilitation Routing Scale walked a median distance of 110 [40; 248] m in the 6-minute walk test (6MWT), 4RP – 300 [240; 350] m in 6MWT, 3RP — 400 [360; 431] m in 6MWT. The difference in 6MWT distance was significant only between 4RP and 3RP groups (p < 0.001). By the end of rehabilitation program, 6MWT increased by 90 m in 5RP group, by 120 m – in 4RP group, and by 89 m in patients with 3RP (p = 0.036 between RPs and 4RP groups; р = 0.007 between 3RP and 5RP groups, respectively). SpO2 was over 95% in all patients by the end of rehabilitation.Conclusion. Comorbid patients after severe COVID-19 demonstrated better rehabilitation potential seen as improvement of exercise tolerance and respiratory status. The original personalized rehabilitation programs improve significantly impaired body functions early on after severe COVID-19.
Effects of physical rehabilitation on exercise tolerance in post-COVID patients: results of an open controlled trial
Authors: Chikina S. Yu. , Kuleshov A. V. , Nikitina N. V. , Meshcheryakova N. N. 
Published: October 2022

The issue of physical rehabilitation of post-COVID patients stays relevant up to this day. Most publications discuss inpatient rehabilitation and only few publications describe outpatient physical rehabilitation of such patients.The aim. Our study was performed to investigate efficacy of outpatient physical rehabilitation of post-COVID patients with lung injury.Methods. This was a prospective non-randomized open controlled study. All patients with COVID-19-associated lung injury were referred to supervised outpatient rehabilitation program. We analyzed 6-minute walk test (6-MWT) results, evaluation of dyspnea using Borg scale and assessment of oxygen saturation (SpO2) using pulse oxymeter before and after walking.Results. The rehabilitation group included 24 patients and the control group included 6 patients. The baseline and demographic findings did not differ significantly between the groups. The 6-minute distance (6-MWD) (р = 0.000018), heat rate at rest (р = 0.017) and after walking (р = 0.017), dyspnea after walking (р = 0.017), oxygen saturation at rest (р = 0.030) and after walking (р = 0.0021) improved significantly in the rehabilitation group and did not change significantly in the control group. At the end of the study, 6-MWD increased by 63.2 ± 36.3 m in the rehabilitation group compared to 14.0 ± 28.8 m in the control group (р = 0,01) and exertional dyspnea score increased by 0 (0 – 1) compared to 1 (1 – 2) in the control group (p = 0.033).Conclusion. Supervised outpatient physical rehabilitation in outpatient settings can accelerate physical recovery in post-COVID patients with lung injury.
Chronic obstructive pulmonary disease and COVID-19
Authors: Zaryanova E. A. , Osipova G. L. , Osipova V. V. 
Published: October 2022

Recently, single studies have described the picture of COVID-19 in patients with chronic obstructive pulmonary disease (COPD). Further study of this comorbid condition will help to assess the course and prognosis of each condition correctly, develop an effective plan for the management of patients with COPD during the pandemic caused by SARS-CoV-2 infection.The aim. The article is an analytical review of the scientific literature from PubMed, Google Scholar, medRxiv, bioRxiv in order to study the clinical features of COVID-19 in patients with COPD. The published studies of the new coronavirus infection showed that patients with COPD account for 2% among those infected with SARS-CoV-2. However, further studies are needed to study the course of COVID-19 in patients with COPD. The conducted studies indicate a high level of ACE2 receptors to SARS-CoV-2 in current smokers and patients with COPD, which may explain the easier penetration of SARS-CoV-2 into the host organism and the severe course of the disease in this population.Conclusion. Although a number of clinical studies strongly suggest that men have more severe COVID-19 than women, the patient’s gender is not always taken into account. It is possible that the more severe course of COVID-19 is associated with the increased prevalence of smoking and COPD in men as compared to women to a lesser extent than with the high production of testosterone and X-linked inheritance of the androgen gene and the ACE2 gene.
Improving the Ability of Teachers in Utilizing the Surrounding Environment as a Learning Resource in the Era of the Covid-19 Pandemic Through In-House Training at SD Negeri Banjarharjo, Kalibawang, Kulon Progo in 2021
Authors: Kandibah Umi 
Published: October 2022

The research aims to improve the ability of teachers to utilize the surrounding environment as a learning resource and increase the professionalism of school principals in the era of the COVID-19 pandemic. The method used in this research is analytical descriptive, which is a study to collect data, describe, process, analyze, interpret and conclude data so that a systematic picture is obtained. Document data collection, observation, and interviews. The research subjects were 9 teachers of Banjarharjo Public Elementary School, Kalibawang Kulon Progo consisting of 6 class teachers and 3 subject teachers. The data collection in this school action research was carried out using instruments consisting of: 1) an instrument for observing participants' abilities, and 2 ) the ability of researchers in managing IHT. The data analysis used in this research is descriptive quantitative data analysis. The expected target in this study is that teachers are able to utilize learning resources with the surrounding environment. The results of the study on the ability of teachers to use the surrounding environment as a learning resource, it was found that an increase in the average score of the first cycle to the second cycle reached 0.50, while based on the percentage there was an increase of 12.45%, with the last average percentage of the second cycle reaching 87 .89%, thus the level of teacher ability has shown a significant increase above the indicator of success, 85%, when viewed from the results based on the conversion of the average value of the second cycle reaching 4, with the "very good" category. Furthermore, the results of research related to the management of the implementation of In House Training (IHT) by researchers in delivering material using the surrounding environment as a learning resource, the results obtained are the average score in cycle I; 3.29, with a percentage of 82.12%, the conversion value reached; 3, with the "Satisfactory" category, while in the second cycle the research results total average score of 3.59, based on a percentage of 89.65%, value conversion; 4, with the category "Very Satisfactory", when compared to cycle I; there is an increase; 7.53%, if it is concluded that the implementation of IHT can have a positive impact on increasing the ability of participants to utilize learning resources using the surrounding environment.

Keywords: Learning Resources, the surrounding environment, In House Training (IHT)
Pengaruh Likuiditas, Profitabilitas, Dan Solvabilitas Terhadap Kebijakan Dividen Pada Perusahaan Otomotif Yang Terdaftar Di Bursa Efek Indonesia Periode 2016-2020
Authors: Rizkiyeh Rizkiyeh , Sudarsono Bambang 
Published: October 2022

Effect of Liquidity, Profitability, and Solvency on Dividend Policy in Automotive Companies Listed on the Indonesia Stock Exchange (IDX) 2016-2020. Under the guidance of Drs. Bambang Sudarsono, MM.This study aims to determine the effect of liquidity, profitability, and solvency variables on dividend policy in automotive companies listed on the Indonesia Stock Exchange (IDX) in 2015-2020.The approach used in this research is quantitative research. The number of samples in this study were 7 companies. The data analysis technique used in this research is multiple linear regression analysis, with hypothesis testing statistical t-test and statistical f-test.Based on the research that has been done, the results show that liquidity and profitability have a significant positive effect on dividend policy, while solvency has no effect on dividend policy, but liquidity, profitability and solvency have a simultaneous positive and significant effect on dividend policy.
TARIAN RANUP LAMPUAN: MENINGKATKAN PERKEMBANGAN FISIK MOTORIK KASAR ANAK USIA DINI
Authors: Tursina Ade , Mahriza Rita , Ramaida Agus 
Published: October 2022

Perkembangan fisik motorik kasar menjadi penting bagi anak usia dini karena berkaitan dengan aspek perkembangan lainnya seperti kepercayaan diri maupun konsep diri, sehingga perlu stimulasi yang tepat. Penelitian ini bertujuan untuk mengetahui bagaimana kegiatan guru dalam upaya meningkatkan kemampuan motorik kasar melalui Tarian Ranup Lampuan di TK Islam Nasurullah dan untuk mengetahui bagaimana peningkatan perkembangan motorik kasar anak melalui Tarian Ranup Lampuan di TK Islam Nasurullah. Metode penelitian yang digunakan adalah penelitian tindakan kelas (action classroom research) melalui dua siklus dengan melibatkan sebanyak 17 anak pada kelompok B di TK Islam Nasurullah. Hasil penelitian ini berupa peningkatan kemampuan guru dalam mengoptimalkan kemampuan motorik kasar anak melalui tarian Ranup Lampuan. Hal ini tampak dari keseluruhan kemampuan guru yaitu siklus I mendapat nilai rata-rata 3,3 dengan kategori “Baik” dan pada siklus II yaitu dengan nilai rata-rata 4,0 dengan kategori “Sangat Baik” dan Tarian Ranup Lampuan dapat meningkatkan kemampuan motorik kasar anak kelompok B1. Apabila dilihat dari hasil rata-rata ketercapaian anak pada siklus 1 yaitu 57,2%, dengan kriteria “Berkembang Sesuai Harapan”. Sedangkan pada siklus II anak meningkat mencapai nilai rata-rata 86,6% dengan kriteria “Berkembang Sangat Baik”. Hal ini telah mencapai kriteria keberhasilan yakni 80%.
Isolation of Total RNA with the Zymo Quick-RNA Miniprep Kit
Authors: Vitucci Eva CM , McCullough Shaun D. 
Published: October 2022

Abstract
This protocol describes the use of the ZYMO Quick-RNA miniprep kit for the isolation and purification of total RNA from cells grown in culture. The conditions described below were developed for the isolation of RNA from H441 and HULEC from the alveolar-capillary region exposure (ACRE) model. Disclaimer: The contents of this article have been reviewed by the US Environmental Protection Agency and approved for publication and do not necessarily represent Agency policy. Mention of trade names or commercial products does not constitute endorsement or recommendations for use. NOTE: There is a consolidated PDF version of this protocol in the supplementary files section below.
Ocean variability beneath Thwaites Eastern Ice Shelf driven by the Pine Island Bay Gyre strength
Authors: Dotto Tiago Segabinazzi , Heywood Karen , Hall Rob , Scambos Ted , Zheng Yixi , Nakayama Yoshihiro , Hyogo Shuntaro , Snow Tasha , Wahlin A. K. , Wild Christian , Truffer Martin , Muto Atsuhiro , Alley Karen , Boehme Lars , Bortolotto Guilherme , Tyler Scott , Pettit Erin 
Published: October 2022

Abstract
West Antarctic ice shelf thinning is primarily caused by ocean-driven basal melting. Here we assess ocean variability below Thwaites Eastern Ice Shelf (TEIS) and reveal the importance of local ocean circulation and sea-ice. Measurements obtained from two sub-ice-shelf moorings, spanning January 2020 to March 2021, show warming of the ice shelf cavity and an increase in meltwater fraction of the upper sub-ice layer. Combined with ocean modelling results, our observations suggest that meltwater from Pine Island Ice Shelf feeds into the TEIS cavity, adding to horizontal heat transport there. We propose that a weakening of the Pine Island Bay gyre caused by prolonged sea-ice cover from April 2020 to March 2021 allowed meltwater-enriched waters to enter the TEIS cavity, which increased the temperature of the upper layer. Our study highlights the sensitivity of ocean circulation beneath ice shelves to local atmosphere-sea-ice-ocean forcing in neighbouring open oceans.
Dynamic behavior of a class of predator-prey model with two time delays
Authors: Peng Yuhui , Ren Meirong , Qian Youhua 
Published: October 2022

Abstract
In this paper, three modified Lesile-Gower predator-prey models with two time delays are considered. Taking the time delay as bifurcation parameter, when Hopf bifurcation occurs, the critical value corresponding to time delay is obtained. By using normal form theory and central manifold argument, the direction of Hopf bifurcation and the stability of bifurcation periodic solution can be determined. Finally, numerical simulation is performed to support theoretical analysis.