bluuebunny/crossref_metadata_2025_split huggingface dataset:
Subsidization of Renal Replacement Therapy in Ghana: Far more overdue
Authors: Okyere Perditer , Okyere Isaac , Essuman Grace , Attakora Joseph , Serwaa Dorcas , Donkoh Irene Esi , Ephraim Richard K.D. 
Published: April 2022

Abstract
Background: The incidence of end stage kidney disease (ESKD) seems to be increasing in Ghana as with the rest of the world. This study compared the sociodemographic features, diagnostic characteristics (clinical, biochemical and imaging) and clinical outcomes of ESKD patients who chose either renal replacement therapy (RRT) or conservative therapy as well as the factors that influenced their choice. Methods: A cross-sectional retrospective study of 382 ESKD patient records at the Komfo Anokye Teaching Hospital (KATH) nephrology clinic during the period of 2006 to 2018. Sociodemographic, diagnostic (clinical, biochemical and imaging) and therapeutic data were obtained, organized and analyzed with Statistical Package for the Social Sciences (SPSS).Results: Of the 382 patients, 321 had conservative therapy whiles 61 had renal replacement therapy. The mean age of participants was 47.71±16.10 years. Major clinical features were bipedal swelling (60), fatigue (37) and facial swelling (32). Chronic glomerulonephritis (31.4%), hypertension (30.3%) and diabetes mellitus nephropathy (28.2%) were the majority predisposing conditions. The RRT patients were more on NifecardXL (82.0) Bisoprolol (32.8%) Aspirin (19.7%) Ranitidine (26.2%), Metformin (13.1%) and Lasix (78.7%) than their conservative therapy counterparts. Whereas conservative therapy patients were more on Irbesartan/Lisinopril (57.9%) and NaHCO3 (52.0%) than their RRT counterparts. Diastolic blood pressure (DBP) (p=0.047), uremic gastritis (p=0.007), anaemia, uraemia, haematuria and hyperkalaemia (p < 0.001) were higher in conservative therapy patients than RRT patients with RRT patients showing better corticomedullary differentiation (38.1% vs. 27.7%, p < 0.001) and normal echotexture (15.0% vs. 11.6%, p=0.005). Variables significantly associated with the decision to opt for conservative therapy were age, gender, occupation and duration of illness. Duration of illness was an independent variable.Conclusion: Conservative therapy is associated with worse clinical features and biochemical derangements than RRT in our participants. Early referrals to nephrologist as well as subsidized RRT should be targeted.
Effects of Let-7c on the Processing of Hepatitis B Virus Associated Liver Diseases
Authors: Zhang Like , Jiang Xia , Wang Guiqi , Kanda Tatsuo , Yokosuka Osamu , Zhai Congjie , Zhang Lei , Liu Peng , Zhao Zengren 
Published: April 2022

Abstract
Background
The most common type of cancer of the digestive system is hepatocellular carcinoma. In China, many patients harbour HBV. The lin28B/Let-7c/MYC axis is associated with the occurrence of many cancers. Therefore, we aimed to illuminate the function of the lin28B/Let-7c/MYC axis in hepatocellular carcinoma. We aimed to evaluate the critical involvement of lin28B and Let-7c in the carcinogenesis of human hepatocellular carcinoma (B-HCC).
Methods
Data from the GEO database were used to analyse differentially expressed genes and IRGs. A protein − protein interaction (PPI) network and Venn diagram were generated to analyse relationships. Real-time RT-PCR, Western blotting, and cell counting kit-8 assays were used to examine the association of lin28B, Let-7c, and MYC with cell proliferation.
Results
A total of 2552 functionally annotated differentially expressed RNAs were analysed in HBV patients from the GSE135860 database. In addition, 46 let-7c target genes were screened in HBV patients, and the interactions were analysed through PPI network analysis. The results confirmed that Let-7c and its target genes play a key role in HBV-related diseases. Next, we discovered a gradual decrease in Let-7c expression during the progression from HBV-associated chronic hepatitis (B-CH) and HBV-associated liver cirrhosis (B-LC) to B-HCC. We found evidence for a negative association between lin28B expression and Let-7c expression. The expression of MYC was obviously upregulated when Let-7c was inhibited.
Conclusion
Our results highlight that Let-7c and lin28B participate in the carcinogenesis of HBV-associated diseases through the lin28B/Let-7c/MYC axis.
Accurate Neural Network Classification Model for Schizophrenia Disease Based on Electroencephalogram Data
Authors: Luján Miguel Ángel , Sotos Jorge Mateo , Santos José L. , Borja Alejandro L. 
Published: April 2022

Abstract
Electroencephalogram is a useful interface system that translates the human electrical brain activity into voltage signals. By these means, the recorded brain waves can be employed to characterize, classify, or diagnose mental disorders. A novel neural network model to classify patients with schizophrenia based on electroencephalograms is presented. The proposed model decomposes the multichannel electroencephalogram records into a group of multivariate novel radial basis functions using a fuzzy means algorithm. The decomposition permits to extract different electroencephalogram channel information and distinguish between two sort of classes i.e., schizophrenic patients and healthy controls. Results show improved accuracy compared to classical algorithms reported in the literature i.e., Support Vector Machine, Bayesian Linear Discriminant Analysis, Gaussian Naive Bayes, K-Nearest Neighbour or Adaboost. As a result, the method presented in this paper achieves the highest balanced accuracy, recall, precision and F1 score values, close to 93 % in all cases. The model presented in this paper may be integrated in real time tools involved during the diagnostic of schizophrenia.
Electrochemical determination of 4-bromophenoxyacetic acid based on eGr/CeO2 composite
Authors: Du Haijun , Zhang Yan , Wang Xin , Hu Huali , Ai Jixing , Zhou Huanxi , Yang Yang 
Published: April 2022

Abstract
Plant growth regulators determination is of great importance for crops quality monitoring. In this work, 4-bromophenoxyacetic acid (4-BPA), one of the phenoxyacetic acid, is detected via electrochemical method for the first time. eGr/CeO2 composite was constructed for the sensing materials due to the synergistic effect of excellent catalytic active sites of CeO2 and good electron transference of electrochemical exfoliated graphene (eGr). The designed eGr/CeO2 sensor has the active surface area of 0.097cm2 and the roughness factor of 2.425. The eGr/CeO2 sensor displayed a good linearity in a wide range from 0.3 to 150 µmol/L and the lowest detection limit is 0.06 µmol/L for 4-BPA detection. Electrochemical determination for 4-BPA is following a diffusion-controlled process on eGr/CeO2 electrode, which involves 2e in the transference processes. This developed eGr/CeO2 sensor has excellent stability with the relative standard deviation (RSD) of 2.35% in 10 continuous measurements, and good reproducibility with RSD of 3.6% in six replicated measurements. Moreover, the recoveries are in the range of 90% − 108% for detecting the 4-BPA in apple juice. The proposed eGr/CeO2 sensor shows a great potential for plant growth regulators detecting in corps.
Evaluation of the Neutrophil-lymphocyte ratio in the prediction of systemic infection in normal newborns in Lubumbashi: Cross-sectional study.
Authors: Assumani Amir Yuma N’Simbo , Nkodila Aliocha Natuhoyila , Gini Jean Lambert Ehungu , Wakamb Gray Kateng A , Mutoba Gauthier Kasansaika , Sangwa Kasim N’simbo , Ngongo Maguy Omoy , Wembonyama Stanislas Okitosho , Luboya Oscar Numbi 
Published: April 2022

Abstract
Background and Purpose: Despite progress in the surveillance of newborns in hospitals around the world in general and the country in particular, systemic infection remains a major concern. The purpose of this study to assess the ability of neutrophil-lymphocyte ratio (NLR) to predict systemic infection in newborns in clinics in Lubumbashi.Methods: Cross-sectional and analytical study that included 430 normal newborns in 25 medical facilities in the city of Lubumbashi, chosen in a simple random manner during the period from November 2015 to December 2017. The clinical and biological characteristics of newborns were studied. Results: out of 430 children who performed a complete blood count, 106 had an NLR> 3, a frequency of systemic infection of 24.7%. The mean values ​​of neutrophils, lymphocytes, esosinophils, basophils monocytes were significantly higher in patients with an NLR> 3. Mean RNL values ​​were 2.5 ± 1.2, it was 1.9 ± 0.6 in children with NLR≤3, and 4.3 ± 1.2 in those with RNL> 3. The area under the curve (AUC) for NLR, Neutrophil, Lymphocyte and Platelet were 0.887, respectively; 0.738, 0.639 and 0.552. NLR is more sensitive and specific in predicting systemic infection compared to neutrophil, lymphocyte and platelet count.Conclusion: The results show that NLR is an effective indicator in the diagnosis of systemic infection than neutrophil, lymphocyte and platelet count.
Green Synthesis of Silver Nanoparticles from Corn Cob Aqueous Extract for Colorimetric Cysteine Detection in Serum Simulated with Cysteine Samples
Authors: Thayumanavan Palvannan , Ragunathan Subash Chandra Bose , Chandrababu Rejeeth , Muthusamy Ganesan , Abdulhaniff Parveen 
Published: April 2022

Abstract
In this study described a green approach for synthesizing silver nanoparticles (AgNPs) with corncob acting as a reducing and stabilizing agent to rapidly detect of L-Cysteine (Cys). To obtain an appropriate condition of synthesizing AgNPs variations in the reactant condition such as concentration, pH, and processing speed were altered. The synthesized AgNPs, that have sizes of 50–100 nm were capped by corncob extract (CCB), became virtually hexagonal and re-dispersed well in aqueous solution. AgNPs were explored for their possible structural characterization. Significantly, the CCB/AgNPs combination demonstrated very high sensitivity for Cys detection with a 30 nM limit of detection (LOD) and selective detection of Cys among 12 amino acids. Furthermore, the CCB/AgNPs combination was applied to detect Cysteine human serum with an error rate of less than 5%. As a result of this work, a rapid approach for Cys detection employing green-synthesized AgNPs was developed.
The exploration of ultrasound-assisted modified paramedian technique for spinal anesthesia in elderly
Authors: Shi Yi-sa , Zeng Wei , Zheng Qi-hui , Du Sheng-fang 
Published: April 2022

Abstract
Background:At present, there are two techniques which are widely applied clinically, including midline technique and paramedian technique,both of them are difficultfor residents when faced with elderly.We aim to explore the feasibility of ultrasound-assisted modified paramedian technique for spinal anesthesia in elderly,in order to provide clinicians with a new and easy-to-operate technique.Methods:A total of 150 elderly patients who were scheduled for urology surgery under spinal anesthesia in our hospital were randomly divided into three groups (n=50) : midline technique group ( group M), paramedian technique group ( group P) and modified paramedian technique group ( group PM) with 50 patients in each group.All spinal anesthesia were performed by the same second-year resident.Results:Compared with groups M and P , group PM had a significantly higher first-attempt success rate (P<0.05,specially in patients aged 65-74 years)，fewer attempts（P<0.05）and higher patient satisfaction score（P<0.05）. Compared with group M,the time taken to perform spinal anesthesia and the number of needle redirections were significantly reduced in group PM (P<0.05), and there was no statistically significant difference between groups PM and P . There were no statistically significant differences in the cases of inconsistency between ultrasound-assisted and landmark-guided location of intervertebral space, the time taken to ultrasound-assisted location,the onset time to pain block at T10,the incidence of hypotension ,anesthesia effect and the incidence of headache, low back pain, nausea and vomiting within 24 hours after surgery.Conclusions: The modified paramedian technique in spinal anesthesia for elderly patients can significantly improve the first-attempt success rate, reduce the number of attempts and reduce procedure time and the damage to patients’ tissue during operation. Compared with the traditional midline and paramedian techniques, modified paramedian technique achieves complementary advantages of the others,easy to learn,which effectively solves the difficulty of spinal anesthesia during the procedure in elderly patients and provides a new operation path for lumbar puncture.It is worthy of further research and application.Trial registration:Prospectively registered at China Clinical Trial Registry, registration number ChiCTR2100047635, date of registration: 21/06/2021.
Characteristics for renal recovery after acute kidney injury in cohorts of elderly and non elderly: a multicenter retrospective cohort study
Authors: zhao xiujuan , li chengjian , lu yunwei , li shu , guo fuzheng , xue haiyan , wang zhenzhou , jiang yulan , liu shaoguang , chai mingming , du tonghai , zhu fengxue 
Published: April 2022

Abstract
Background: Failure to recover renal function after acute kidney injury (AKI) is associated with an increase in long-term mortality. The characteristics of renal recovery in elderly and nonelderly cohorts are not clear. The purpose of this study was to explore the risk factors for renal nonrecovery among elderly and nonelderly patients with acute kidney injury (AKI).Methods: A multicenter retrospective cohort of 583 critically ill patients with AKI was examined. All patients were divided into two cohorts, age < 63 and age ≥ 63 years old; on the basis of renal recovery at 30 days after AKI, the two patient cohorts were further divided into a renal recovery group and a renal nonrecovery group. Multivariate logistic regression was used to analyze the risk factors affecting renal recovery in the two cohorts.Results: The 30-day renal recovery rate of patients aged < 63 years was 67.5% (191/283), multivariate analysis showed that the independent risk factors affecting renal nonrecovery in age < 63 years old included AKI stage, blood lactate level and hemoglobin level, the AUC for predicting renal nonrecovery was 0.876 (95% CI, 0.835-0.917). The 30-day renal recovery rate of patients aged ≥ 63 years was 32.3% (97/300), multivariate analysis showed that the independent risk factors for renal nonrecovery in age ≥ 63 years old included diabetes mellitus, surgery with general anesthesia, AKI stage, APACHE II score and hemoglobin level. The AUC for predicting renal nonrecovery was 0.863 (95% CI, 0.816-0.909).Conclusions: The renal nonrecovery after AKI in patients aged ≥ 63 years was more strongly affected by multiple risk factors, such as diabetes mellitus, surgery with general anesthesia and APACHE II score, in addition to hemoglobin and AKI stage.
Theoretical study of metal-free catalytic for catalyzing CO-oxidation with a synergistic effect on P and N co-doped graphene
Authors: Hadsadee Sarinya , Jungsuttiwong Siriporn , Zhang Rui-Qin , Rungrotmongkol Thanyada 
Published: April 2022

Abstract
P and N co-doped graphene (PNxCy-G with x = 1, 2, 3 and y = 0, 1, 2) is designed to enhance graphene reactivity with a synergistic effect of the P and N atoms for the CO oxidation reaction, focusing on the influence of the N dopant concentration on graphene. The calculated results indicate that increasing two or three coordinated N to P can facilitate charge transfer from the surface onto O2 molecules. However, the adsorbed O2 molecule breaks apart on PN3-G surface, affecting CO oxidation performance. Furthermore, PN2C1-G exhibits excellent catalytic activity towards the oxidation of CO via the ER mechanism, which catalyzes CO oxidation with the rate-determining step of only 0.26 eV for the first and 0.25 eV for the second oxidation at 0 K. Additionally, the catalytic oxidation of PN2C1-G via Eley-Rideal mechanism prefers to occur at room temperature (298.15 K), with a rate-determining step of 0.77 eV. The reaction rates at 298.15K is calculated to be 5.36 x1016 mol s–1. The rate constants are obtained according to harmonic transition state theory, which could be supportive for catalytic oxidation of CO on the experiment.
An optimal control model for the transmission dynamics of Lassa fever
Authors: Madubueze Chinwendu E. , Chazuka Zviiteyi 
Published: April 2022

Abstract
In this paper, a mathematical model for Lassa fever transmission dynamics with rodent logistic growth is developed and analysed. The stability analysis of the autonomous system of the model is presented. The sensitivity analysis of the parameters is performed using the Partial Rank Correlation Coefficient (PRCC) technique. The non-autonomous model is further analysed for stability of disease-free periodic equilibrium(DFPE) in terms of reproduction number ratio, $R_{0t}.$ It shown that DFPE is locally asymptotically stable when $R_{0t}<1$ and unstable if $R_{0t}>1$. Additionally, the optimal control model is formulated with five control measures namely; personal protective equipment and avoiding hunting of rodents, proper handling of food, treatment and isolation, cleaning and disinfecting the environment, and rodent control. Simulations of the optimal control model show that the combined implementation of the five control measures reduce Lassa fever spread in the population. However, when there is limited resources to implement the five control measures, three or four combined control measures can be implemented provided that proper handle of food is among the combined control measures.
Characterization of the Complete Mitochondrial Genome Sequence of Contracaecum sp. (Nematoda: Ascarididae) from China
Authors: Deng Yuan-Ping , Li Rong , Wang Hui-Mei , Liu Guo-Hua , Tu Ya 
Published: April 2022

Abstract
Contracaecum spp. is a zooparasitic anisakid nematode and occurs in gastrointestinal tracts of vertebrate/invertebrate animals, humans included, causing gastrointestinal pain, diarrhea, and increasingly severe vomiting. To date, thousands of sequences have been published in GenBank, while complete mitochondrial genomes (mitogenome) of Contracaecum spp. are still limited. Although the complete mitogenome of Contracaecum species isolated from night herons in Beijing has been reported, the detailed information about it is still puzzling. In the present study, we describe the detailed characteristics within the complete mt DNA Contracaecum sp.. The AT-content in the complete mitogenome of Contracaecum sp. was 72.2%. The nucleotide diversity (Pi) among genus Contracaecum ranged from 0.124 (cox1) to 0.181 (nad4). Based on the computational algorithms Maximum Likelihood (ML) and Bayesian Inference (BI) within Ascaridoidea and Heterakoidea, the results supported Contracacum sp. Beijing isolate was a new species in the genus Contracaecum, and supported the family Ascaridiidae was paraphyletic.
NeuroMorpho Access Tool: A Simple GUI for Accessing NeuroMorpho.Org Database
Authors: Zaletel Ivan , Vidaković Marko , Nowakowski Richard S. 
Published: April 2022

Abstract
The use of open-access data has become increasingly prevalent in modern neuroscience research. These data are commonly used as a supplement to practical experimental research, but there is also an increasing body of literature which relies exclusively on the use of such publicly available data. Although freely available, these databases usually require an adequate level of training in bioinformatics and/or programming for a researcher to access them, which limits their usability. One of the oldest, most utilized and maintained databases of neuron and glia cell morphology is the NeuroMorpho.Org database, which can be access through the use of application programing interface (API). In the present paper we introduce the NeuroMorpho Access Tool (NMAT), a simple and user-friendly graphical user interface (GUI) program, which allows easy and fast access to the NeuroMorpho.Org database to any neuroscientist, regardless of their previous bioinformatics knowledge. The core of NMAT was built in Python, utilizes the NeuroMorpho.Org API in order access the database, and has a GUI built in Qt environment. The program is lightweight, consists of only one executable file and does not require any extensive accompanying instructional or technical documentation. The current version of the program enables the users to obtain cell reconstruction data together with morphometry data and also acquire images of cell reconstructions. The main advantage of NMAT is its multithreading capability, which allows the users to gain access to a large amount of data in a very short time period. Thus, NMAT may prove as a usefully tool which would complement the highly utilized NeuroMorpho.Org database.
Facile development of multifunctional photoluminescent linen fabrics for high performance textile applications
Authors: Ahmed Esraa , Maamoun Dalia , Hassan Talaat M. , Khattab Tawfik 
Published: April 2022

Abstract
Linen fibers were coated with a luminous, flame-retardant, and hydrophobic smart nanocomposite utilizing the pad-dry-curing process. Ecologically-friendly ammonium polyphosphate and lanthanide-activated strontium aluminum oxide (LSAO) nanoparticles were immobilized into linen fabric using the eco-friendly RTV silicone rubber. Scanning electron microscopy (SEM), energy-dispersive X-ray (EDX), X-ray fluorescence (XRF) spectroscopy, Fourier-transform infrared (FTIR) spectroscopy, and transmission electron microscopy (TEM) were employed to examine the morphological characteristics and elemental compositions of LSAO nanoparticles and treated linen textiles. The self-extinguishing properties of the treated linen textiles were tested for their fire-resistance. After 24 washing cycles, the coated linen samples retained their flame-retardant properties. The treated linen's superhydrophobicity rose in direct proportion to the LSAO concentration. After being excited at 365 nm, the colorless luminescent film that was coated on linen surface gave out an emission wavelength of 519 nm. The photoluminescent linen was monitored to create a range of different colors, including off-white in daytime light and green under UV radiation, according to the CIE Lab colorimetric coordinates and photoluminescence spectra. Emission, excitation and lifetime spectral analysis of the treated linen revealed persistent phosphorescence. For mechanical and comfort evaluation, the coated linen textiles' bending length and air permeability were assessed. Excellent UV protection and enhanced antibacterial properties were found in the treated linens. Large-scale manufacturing of multipurpose technical fabrics, such as tents, might benefit from the current simple technique.