bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identification of Subgroups of Children in the Australian Autism Biobank using Latent Class Analysis
Authors: Montgomery Alicia , Masi Anne , Whitehouse Andrew , Veenstra-VanderWeele Jeremy , Shuffrey Lauren , Shen Mark , Karlov Lisa , Uljarevic Mirko , Alvares Gail , Woolfenden Susan , Silove Natalie , Eapen Valsamma 
Published: August 2022

Abstract
Background: The identification of reproducible subtypes within autistic populations is a priority research area in the context of neurodevelopment, to pave the way for identification of biomarkers and targeted treatment recommendations. Few previous studies have considered medical comorbidity alongside behavioural, cognitive, and psychiatric data in subgrouping analyses. This study sought to determine whether differing behavioural, cognitive, medical, and psychiatric profiles could be used to distinguish subgroups of children on the autism spectrum in the Australian Autism Biobank (AAB).Methods: Latent profile analysis was used to identify subgroups of children on the autism spectrum within the AAB (n=1151), utilising data on social communication profiles and restricted, repetitive, and stereotyped behaviours (RRBs), in addition to their cognitive, medical, and psychiatric profiles.Results: Our study identified four subgroups of children on the autism spectrum with differing profiles of autism traits and associated comorbidities. Two subgroups had more severe clinical and cognitive phenotype, suggesting higher support needs. For the ‘Higher Support Needs with Prominent Language and Cognitive Challenges’ subgroup, social communication, language and cognitive challenges were prominent, with prominent sensory seeking behaviours. The ‘Higher Support Needs with Prominent Medical and Psychiatric and Comorbidity’ subgroup had the highest mean scores of challenges relating to social communication and RRBs, with the highest probability of medical and psychiatric comorbidity, and cognitive scores similar to the overall group mean. Individuals within the ‘Moderate Support Needs with Emotional Challenges’ subgroup, had moderate mean scores of core traits of autism, and the highest probability of depression and/or suicidality. A fourth subgroup contained individuals with fewer challenges across domains (the ‘Fewer Support Needs Group’).Limitations: Data utilised to identify subgroups within this study was cross-sectional as longitudinal data was not available.Conclusions: Our findings support the holistic appraisal of support needs for children on the autism spectrum, with assessment of the impact of co-occurring medical and psychiatric conditions in addition to core autism traits, adaptive functioning, and cognitive functioning. Replication of our analysis in other cohorts of children on the autism spectrum is warranted, to assess whether the subgroup structure we identified is applicable in a broader context beyond our specific dataset.
Synthesis of Mo–doped symbiotic mixture of Bi2WO6 and Bi6O6(OH)3(NO3)3·1.5H2O nanosheets with enhanced photocatalytic degradation for Mustard gas simulator 2-CEES
Authors: Yang Haoguo , Guo Yijun , Han Shitong , Xi Hailing , Lin Huaxiang , Yuan Rusheng , Long Jinlin , Lin Qun 
Published: August 2022

Abstract
Symbiotic mixture of Bi2WO6 and Bi6O6(OH)3(NO3)3·1.5H2O nanosheets doped with Mo (Mo-B-B) have been synthesized by a facile hydrothermal treatment. The as-prepared samples were investigated by XRD, DRS, XPS, SEM, TEM, Raman and PL. The photocatalytic activity of the samples were test by the degradation of 2-CEES under visible-light irradiation. The results showed that the doped Mo reduce the Eg of bare symbiotic mixture and improve the photocatalytic activity. The optimum amount of doped Mo is 5% that exhibit the best activity for degradation for 2-CEES. The FT-IR test confirmed that the degradation products of 2- CEES are mainly CO2 and CO.
Dispersal in Time-
the role of seed banks in patchy population dynamics of an aquatic plant
Authors: Tomowski Maxi , Lozada-Gobilard Sissi , Jeltsch Florian , Tiedemann Ralph 
Published: August 2022

Abstract
Progressive habitat fragmentation increasingly threatens plant species with narrow habitat requirements. While local environmental conditions largely define population growth rates and recruitment success at the patch level, dispersal is critical for population viability at the landscape scale. However, identifying dynamics of plant metapopulations in habitat networks is often confounded by the uncertainty of the extent of dormant population compartments. Here, we combined a landscape-scale assessment of an amphiphytic species’ population structure with detailed measurements of dispersal complexity in time to reveal past and present dispersal events and putative shifts in functional connectivity. Using 13 polymorphic microsatellite markers, we analyzed the genetic structure of extant Oenanthe aquatica populations and their soil seed banks in a kettle hole system to uncover hidden connectivity among subpopulations in both time and space. Considerable spatial genetic structure and isolation-by-distance (IBD) patterns suggest limited gene flow between population sites. In contrast, patch level measures of isolation and habitat availability showed minor effects on genetic diversity levels. Low differentiation along the time gradient highlights the superior role of temporal over spatial dispersal. Though some instances of recent colonisation were observed, our results suggest the actual genetic structure of kettle hole populations to result from multiple local seed rain events. Our findings uncover stepping-stone dynamics with source-sink effects based primarily on dispersal from long-term-persistent local populations to adjacent populations. Overall, spatio-temporal connectivity patterns provide support for metapopulation dynamics in our studied system and highlight the importance of persistent seed banks as long-term source of genetic diversity.
Radiation-induced sarcomas of the breast: A review of a 20-year single-centre experience
Authors: Lalla Vanessa Di , Tolba Marwan , Khosrow-Khavar Farzin , Baig Ayesha , Freeman Carolyn , Panet-Raymond Valerie 
Published: August 2022

Abstract
Purpose
Radiation-induced sarcomas (RIS) are histologically proven sarcomas within or around a previously irradiated site, per Cahan’s criteria. RIS incidence is higher in breast cancer compared to other solid cancers and prognosis remains poor given limited treatment options. This study aimed to review 20-year experience with RIS at a large tertiary care centre.
Methods
Using our institutional cancer registry database, we included patients meeting Cahan’s criteria diagnosed between years 2000 to 2020. Patient demographics, oncologic treatment, and oncologic outcomes data were collected. Descriptive statistics were used to describe demographic data. Oncologic outcomes were assessed using the Kaplan Meier method.
Results
Nineteen patients were identified. The median age at RIS diagnosis was 72 years (range 39–82) and median latency period for development of RIS was 112 months (range 53–300). All patients underwent surgery, 3 patients received systemic therapy, and 6 patients received re-irradiation as salvage treatment. The median follow-up time was 31 months (range 6-172) from diagnosis of RIS. Overall, 5 patients had local recurrence and 1 patient developed distant metastases. The median time to progression was 7 months (range 4–14). The progression-free survival (95% CI) at two years was 56.1% (37.4–84.4%). At two years follow-up after sarcoma diagnosis, the overall survival (95% CI) was 88.9% (75.5–100%).
Conclusion
While breast RIS remains rare, when managed in a high patient-volume centre, overall survival outcomes appear favorable. A significant proportion of patients recur locally after maximal treatment and require salvage therapy to improve outcome. These patients should be managed in high-volume centres where multidisciplinary expertise is available.
SMPD1 Expression Profile and Mutation Landscape Help Decipher Genotype–Phenotype Association and Precision Diagnosis for Niemann–Pick Disease Types A and B
Authors: Wang Ruisong , Qin Ziyi , Huang Long , Luo Huiling , Peng Han , Zhou Xinyu , Zhao Zhixiang , Liu Mingyao , Yang Pinhong , Shi Tieliu 
Published: August 2022

Abstract
Background: Types A and B of the rare genetic disease Niemann–Pick disease (NPD) are caused by mutations in the SMPD1 gene, which encodes sphingomyelin phosphodiesterase (ASM). Except for the liver and spleen enlargement and lung disease, the two subtypes have different onset times, survival times, ASM activities, and neurological abnormalities. To comprehensively explore the genotype-phenotype association and pathophysiological characteristics of NPD, we collected 144 NPD cases with strict quality control through literature mining. Results: The difference in ASM activity can differentiate NPD type A from other subtypes, with the ratio of ASM activity to the reference values being lower in type A (threshold 0.045 (4.45%)). Severe variations, such as deletion and insertion, can cause complete loss of ASM function, leading to type A, whereas relatively mild missense mutations generally result in type B. Among reported mutations, p.Arg3AlafsX76 mutation is highly prevalent in the Chinese population, and p.R608del mutation is common in Mediterranean countries. The expression profiles of SMPD1 from GTEx and single-cell RNA sequencing data of multiple fetal tissues showed that high expressions of SMPD1 can be observed in the liver, spleen, and brain tissues of adults and in hepatoblasts, hematopoietic stem cells, STC2_TLX1-positive cells, mesothelial cells of the spleen, vascular endothelial cells of the cerebellum and the cerebrum of fetuses, indicating that SMPD1 dysfunction is highly likely to have a significant effect on the function of those cell types during development and the clinicians need pay attention to these organs or tissues as well during diagnosis. In addition, we also predicted 21 new pathogenic mutations in the SMPD1 gene that potentially cause the NPD, signifying that more rare cases will be detected with those mutations in SMPD1. Conclusions: Our study is the first one to elucidate the effects of SMPD1 mutation on cell types and at the tissue level, which provides new insights into the genotype-phenotype association and can help in the precise diagnosis of NPD.
Simulation and Monitoring of Marine Diesel engine Machining workshop based on digital twin
Authors: Fang Xifeng , Guo Mingyi , Hu Zhongtai , Wu Qi , Zhang Shengwen , Gong Chanyuan , Wang Tongyue , Li Qun 
Published: August 2022

Abstract
In order to solve the current large processing workshop information degree is low, part of the information can not be immediately grasped, reaction lag and other problems. In this paper, key techniques of twin Marine diesel engine to develop digital processing workshops, the traditional Marine diesel engine processing workshop combined with digital twin technology, through the twin body build four-dimensional model the virtual workshop is established in this paper, based on the digital twin software service platform building workshop, unicom virtual workshop and physical workshop, make full use of the whole life cycle of Marine diesel engine processing data, Realize twin simulation and monitoring of physical workshop. Finally, the practical case is used to verify the practicality of the system.
In God’s virtual shoes: embodying the avatar of an omnipotent agent modulates the perception of one’s own abilities and enhances feelings of invulnerability
Authors: Frisanco Althea , Schepisi Michael , Tieri Gaetano , Aglioti Salvatore Maria 
Published: August 2022

Abstract
Immersive virtual reality can give people the illusion of owning artificial bodies (i.e., avatars) and controlling their actions. Tellingly, people appear to adhere to the newly embodied entities not just on the basis of physical traits but also behaving accordingly with the hallmarks of the represented characters. In two studies we pushed the limits of this process by testing if one’s own sense of power could be affected by embodying the anthropomorphic representation of the Christian God, that is considered an omnipotent entity. A human Muscled and a Normotype avatar were used as controls. Results showed that participants embodying the God-avatar: i) reacted to a threatening event compromising their physical safety by exhibiting a lower skin conductance response and heart rate deceleration compared to the Normotype-control avatar (Study 1); ii estimated they had more physical abilities compared to both the Normotype-control and the Muscled-control avatars (Study 2). Taken together, our findings suggest that embodying an omnipotent agent may exert an influence on people’s perception of their own limits and capabilities, nourishing feelings of physical invulnerability and strength. Our study indicates that effectively embodying virtual role models may boost achievements and have translational implications in the field of empowerment.
Changes in Self-Reported and Accelerometer-Measured Physical Activity Among Pregnant TRICARE Beneficiaries
Authors: Pebley Kinsey , Farage Gregory , Hare Marion E. , Bursac Zoran , Andres Aline , Chowdhury Sultana Mubarika Rahman , Talcott Gerald Wayne , Krukowski Rebecca A. 
Published: August 2022

AbstractBackground:Physical activity is recommended for all pregnant individuals and can prevent excessive gestational weight gain. However, physical activity has not been assessed among military personnel and other TRICARE beneficiaries, who experience unique military lifestyles. The current study assessed physical activity among pregnant TRICARE beneficiaries, both active duty and non-active duty, as measured by accelerometry and self-report data to examine potential predictors of physical activity engagement in the third trimester, and if self-report data was consistent with accelerometry data. We expected having a lower BMI, being active-duty, and having higher baseline physical activity engagement to be associated with higher physical activity at 32-weeks. We also hypothesized that accelerometry data would show lower physical activity levels than the self-reported measure.Methods:Participants were 430 TRICARE adult beneficiaries (204 Active Duty; 226 non-Active Duty) in San Antonio, TX who were part of a randomized controlled parent study that implemented a stepped-care behavioral intervention. Participants were recruited if they were less than 12-weeks gestation and did not have health conditions precluding dietary or physical activity changes (e.g., uncontrolled cardiovascular conditions) or would contribute to weight changes. Participants completed self-report measures and wore an Actical Activity Monitor accelerometer on their wrist to collect physical activity data at baseline and 32-weeks gestation.Results:Based on the accelerometer data, 99% of participants were meeting moderate physical activity guidelines recommending 150 minutes of moderate activity per week at baseline, and 96% were meeting this recommendation at 32-weeks. Based on self-report data, 88% of participants at baseline and 92% at 32-weeks met moderate physical activity recommendations. Linear regression and zero-inflated negative binomial models indicated that baseline physical activity engagement predicted moderate physical activity later in pregnancy above and beyond BMI and military status. Surprisingly, self-reported data, but not accelerometer data, showed that higher baseline activity was associated with decreased vigorous activity at 32-weeks gestation. Additionally, self-report and accelerometry data had small correlations at baseline, but not at 32-weeks.Conclusions:Future intervention efforts may benefit from intervening with individuals with lower pre-pregnancy activity levels, as those who are active seem to continue this habit.
DEVELOPMENTAL EFFECTS OF BISPHENOL A and ITS ANOLOGS BISPHENOL S, BISPHENOL F AND BISPHENOL AF ON EMBRYONIC DEVELOPMENT OF SEA URCHINS Paracentrotus lividus (Lamarck 1816) and Arbacia lixula (Linnaeus 1758)
Authors: Arslan Özlem Çakal 
Published: August 2022

Abstract
Restricting the use of BPA, environmental concentrations of Bisphenol S, bisphenol F and bisphenol AF begin to increase. Because of, no data is available about the possible toxic effects of BPA analogs on sea urchin embryos, this study aims to investigate the developmental effects of bisphenol and its analogs on sea urchin embryos by embryotoxicity bioassay with two sea urchin species Paracentrotus lividus and Arbacia lixula. The EC50 (Effective Concentration 50) for 72 hours was determined as 1.396 mg-BPA/L for sea urchin A. lixula and 0.676 mg-BPA/L (EC50) was estimated for BPA for P. lividus. The EC50 for BPS, BPF, and BPAF were determined as 2,673 mg-BPS/L, 1,129 mg-BPF/L, and 0,314 mg-BPAF/L for A. lixula. It can be concluded that these chemicals adversely affect the embryonic developmental stages of the P. lividus and A. lixula this is of great ecological importance due to the hazard at the population level.In this way, result of this study present the nominal effective concentrations of BPA and its analogs and the suitability of the species for use as a biomarker in ecotoxicology tests.
Young serum protects against memory impairment in APP/PS1 transgenic mice by blocking neutrophil infiltration
Authors: Guo Kaihua , Qi Fangfang , Zuo Zejie , Hu Kaishun , Wang Rui , Wu Tong , Liu Hao , Tang Jiaoling , Wang Qingbo , Xie Yufeng , Tan Liren , Yang Yunjie , Zhang Xiaoran , Xu Jie , Yao Zhibin , Wang Shengwen , Wu Long-Jun 
Published: August 2022

Abstract
Activation of innate immunity in the brain is a prominent feature of Alzheimer's disease (AD). The present study investigated the regulation of innate immunity by young serum in a transgenic AD mouse model. We found that young serum significantly reduced the number of neutrophils and microglial reactivity in the brains of APP/PS1 mice. Neutrophil depletion via Ly6G neutralizing antibodies mimicked the benefits of young serum on AD brain functions. Serum proteomic analysis of young serum revealed significant enrichment of the factors VEGF-A and CXCL1, which are crucial for neutrophil migration and chemotaxis, leukocyte migration, and cell chemotaxis. Intravenously injected VEGF-A reversed Aβ-induced decreases in Cdk5 and increases in CXCL1 in vitro and blocked neutrophil infiltration into the AD brain. Endothelial Cdk5 overexpression conferred an inhibitory effect on CXCL1 and neutrophil infiltration and thereby restored memory in APP/PS1 mice. Our data uncover a previously unknown link between blood-derived VEGF signaling and neutrophil infiltration and provide a rationale for targeting endothelial Cdk5 signaling as a potential therapeutic strategy for AD.
Ecological speciation of Japanese Hedgehog mushroom: Hydnum subalpinum sp. nov. is distinguished from its sister species H. repando-orientale by means of integrative taxonomy
Authors: Sugawara Ryo , Aoki Wataru , Yamada Akiyoshi , Nakagiri Akira , Endo Naoki 
Published: August 2022

Abstract
Hydnum repando-orientale is an East Asian species closely related to H. boreorepandum and H. repandum; all three species produce edible mushrooms. We identified two ecological groups of H. repando-orientale in Japan: a temperate group occurring in Fagaceae-dominated forest at < 1200 m a.s.l. (ROF), and a subalpine group occurring in coniferous forest in highland at > 1900 m a.s.l. (ROC). We re-examined the taxonomy of the two ecological groups of H. repando-orientale using integrative approaches. Phylogenies of the two ecological groups and other related species were inferred from the internal transcribed spacer (ITS) and gene portions encoding the large subunit of nc rRNA (LSU), translation elongation factor-1 alpha (TEF1), RNA polymerase II largest subunit (RPB1), and RNA polymerase II second-largest subunit (RPB2). The concatenated phylogenetic tree separated the two ecological groups into well-supported sister clades. Also, species delimitations based on the topological congruence (GCPSR) and multispecies coalescent model (GMYC and BP&P) supported to separate the two ecological groups. Morphological analysis showed that ROC specimens had significantly larger basidiospores, compared with ROF specimens. Mon-mon mating tests using six ROF, three ROC, and three H. boreorepandum strains each showed independent incompatible groups, whereas one ROC strain showed compatibility with both ROC and ROF populations. Based on these results, we defined the ROC group as a new species, H. subalpinum. Because H. repando-orientale and H. subalpinum have smaller genetic divergence in nc rDNA and maintain slight sexual compatibility, they may have recently speciated in East Asia.
Towards Hybrid Collaboration Spaces - A Model of Support Requirements for Hybrid Collaboration
Authors: Augstein Mirjam , Neumayr Thomas , Schönböck Johannes , Kovacs Carrie 
Published: August 2022

Abstract
Triggered by the COVID-19 pandemic, the popularity of hybrid work and collaboration has increased drastically in recent years. This raises a need for diverse and flexible Hybrid Collaboration Spaces (i.e., the physical and virtual rooms in which hybrid collaborative interactions happen) tailored to the respective settings. So far, to the best of our knowledge, no general formal elicitation of requirements for such spaces has taken place. The elicitation and definition of (user or system) requirements is often a lengthy and costly process. This is even more true for novel settings which lack an established catalog of lessons learned. Moreover, requirements established for one scenario might be poorly generalizable to other scenarios. In this conceptual work, we first systematically compare existing CSCW models and frameworks, and then propose a novel two-view model of requirements for hybrid meetings and collaboration spaces. Our model builds upon and joins the descriptive power of two existing instruments: the Domino framework and its hybrid collaborative coupling styles of Neumayr et al., and Bill Buxton's Media Spaces (i.e., Person, Task, and Reference Space). It is intended to allow for the a priori estimation of which support mechanisms might be beneficial in a certain hybrid collaboration scenario.
Acid Ceramidase Gene Therapy Ameliorates Pulmonary Arterial Hypertension with Right Heart Dysfunction
Authors: Katz Michael G. , Hadas Yoav , Vincek Adam , Freage-Kahn Lina , Shtraizent Nataly , Madjarov Jeko M. , Pastuszko Peter , Eliyahu Efrat 
Published: August 2022

Abstract
BackgroundUp-regulation of ceramides in pulmonary arterial hypertension (PAH), contributing to perturbations in sphingolipid homeostasis and the transition of cells to a senescence state. We assessed the safety, feasibility, and efficiency of acid ceramidase gene transfer in a rodent PAH model.MethodsA model of PAH was created by the combination of pneumonectomy and injection of Sugen toxin. Magnetic resonance imaging and right heart catheterization confirmed development of PAH. Animals were subjected to intratracheal administration of synthetic adeno-associated viral vector (Anc80L65) carrying the acid ceramidase (Anc80L65.AC), an empty capsid vector, or saline. Therapeutic efficacy was evaluated 8 weeks after gene delivery.ResultsHemodynamic assessment four weeks after PAH model creation demonstrated an increase in the mean pulmonary artery pressure to 30.4 ± 2.13 mmHg versus 10.4 ± 1.65 mmHg in sham (p < 0.001), which was consistent with the definition of PAH. We documented a significant increase in pulmonary vascular resistance in the saline-treated (6.79 ± 0.85 mm Hg) and empty capsid (6.94 ± 0.47 mm Hg) groups, but not in animals receiving Anc80L65.AC (4.44 ± 0.71 mm Hg, p < 0.001). Morphometric analysis demonstrated an increase in medial wall thickness in control groups in comparison to those treated with acid ceramidase. After acid ceramidase gene delivery, a significant decrease of pro-inflammatory factors, interleukins, and senescence markers was observed.ConclusionGene delivery of acid ceramidase provided tropism to pulmonary tissue and ameliorated vascular remodeling with right ventricular dysfunction in pulmonary arterial hypertension.