bluuebunny/crossref_metadata_2025_split huggingface dataset:
A novel senescence-related lncRNA signature that predicts prognosis and the tumor microenvironment in patients with lung adenocarcinoma
Authors: Fang Xueying , Huang Enmin , Xie Xiaopeng , Yang Kai , Wang Shuqian , Huang Xiaoqing , Song Mei 
Published: November 2022

Background: Cellular senescence has recently been considered a new cancer hallmark. However, the factors regulating cellular senescence have not been well characterized. The aim of this study is to identify long non-coding RNAs (lncRNAs) associated with senescence and prognosis in patients with lung adenocarcinoma (LUAD).Methods: Using RNA sequence data from the Cancer Genome Atlas Lung Adenocarcinoma (TCGA-LUAD) and senescence genes from the CellAge database, a subset of senescence-related lncRNAs was first identified. Then, using univariate and multivariate Cox regression analyses, a senescence lncRNA signature (LUADSenLncSig) associated with LUAD prognosis was developed. Based on the median LUADSenLncSig risk score, LUAD patients were divided into high-risk and low-risk groups. Kaplan-Meier analysis was used to compare the overall survival (OS) in the high- and low-risk score subgroups. Differences in Gene Set Enrichment Analysis (GSEA), immune infiltration, tumor mutation burden (TMB), tumor immune dysfunction and exclusion (TIDE) module score, chemotherapy, and targeted therapy selection were also compared between the high-risk and low-risk groups.Results: A prognostic risk model was obtained consisting of the following nine senescence-related lncRNAs: LINC01116, AC005838.2, SH3PXD2A-AS1, VIMS-AS1, SH3BP5-AS1, AC092279.1, AC026355.1, AC027020.2, and LINC00996. The LUADSenLncSig high-risk group was associated with poor OS (hazard ratio = 1.17, 95% confidence interval = 1.102–1.242; p &lt; 0.001). The accuracy of the model was further supported based on receiver operating characteristic (ROC), principal component analysis (PCA), and internal validation cohorts. In addition, a nomogram was developed consisting of LUADSenLncSig for LUAD prognosis, which is consistent with the actual probability of OS. Furthermore, immune infiltration analysis showed the low-risk group had a stronger anti-tumor immune response in the tumor microenvironment. Notably, the levels of immune checkpoint genes such as CTLA-4, PDCD-1, and CD274, and the TIDE scores were significantly higher in the low-risk subgroups than in high-risk subgroups (p &lt; 0.001). This finding indicates the LUADSenLncSig can potentially predict immunotherapy efficacy.Conclusion: In this study, a lncRNA signature, LUADSenLncSig, that has dual functions of senescence phenotype identification and prognostic prediction as well as the potential to predict the LUAD response to immunotherapy was developed.
Characterization of magnetorheological fluids based on capillary magneto-rheometer
Authors: Wen Mingfu , Du Yueqian , Liu Runduo , Li Zeqin , Rao Longshi , Xiao Hongwei , Ouyang Yi , Niu Xiaodong 
Published: November 2022

Magnetorheological fluids (MRFs) are a class of smart magnetic controlled materials whose rheological properties can be controlled by a magnetic field. These materials have advantages of short response time, high dynamic range and low energy consumption. Due to their excellent properties, MRFs have a widely application potential in the field of impact mitigation. As the shear rate dependent viscosity of MRFs is astonishing for the shear thinning effect, thus it is crucial to study the rheological properties cross a wide range of shear rates for guiding the design and application of MRFs based adaptive impact absorbers. Commercial rotational rheometers are usually used to test the rheological properties of MRFs, but their range of measuring shear rates are limited. Commercial capillary rheometers are designed to measure the rheological behavior over a wide range of shear rates, but they’re usually lack of ability to measure with magnetic field. In order to study the rheological properties of MRFs under higher shear rate and applied magnetic field, a lab-made speed-controlled capillary magneto-rheometer is developed in the presnt work; The expressions for equivalent shear rate and apparent viscosity of MRFs under the dimensional constraint of the set-up are derived. In addition, the theoretical expression of shear rate of MRFs is modified by Rabinowitsch correction. Then, the rheological properties of three particle volume fractions (10%, 15%, and 20%)of MRFs with different magnetic field strengths (6 mT, 13 mT, 20 mT, and 25 mT)are tested and analyzed, and the rheological characteristic curves of MRFs with shear rate range of 101s−1–105s−1 are obtained with the normalized characterization using Mason number. According to the experimental results, the MRFs show an obvious shear thinning phenomenon as shear rate increases, and in the Mason number based normalized characterization, the curves of different particle volume fractions are collapse to a master curve.
Interfacial treatment-induced high-strength plant fiber/phenolic resin composite
Authors: Zhou Shaoqian , Chen Xueying , Huang Rixin , Lin Yi , Ye Xiaoxia 
Published: November 2022

Plant straw fibers have been used widely in composite materials as reinforcement due to their advantages of low density, easy degradation, low cost, and abundance. However, the mechanical properties and water resistance of the as-prepared composites are limited due to the poor compatibility between plant straw fibers and polymer matrix. In this work, the rice straw fibers were pretreated with the silane coupling agent, lipase, and hydrothermal, and then blended with phenolic resin to prepare composites. The results showed that the pretreatment of the fibers can improve their compatibility with the resin matrix and improve the comprehensive mechanical properties and the thickness swelling of composites. When the mass ratio of fiber to resin is 1:1 and the hot-pressing condition is 160°C and 11 min, the static bending strength, elastic modulus, and thickness swelling of the phenolic resin/lipase-treatment rice straw fibers (PF/L-SF) composite reached 23.03 MPa and 2588.39 MPa, which increased by 32.9% and 30.5% compared with the unmodified fiber/phenolic resin composite (PF/SF).
Elevated cerebrospinal fluid protein levels associated with poor short-term outcomes after spinal cord stimulation in patients with disorders of consciousness
Authors: He Qiheng , Li Tianfei , Xiong Ying , Xia Xiaoyu , Dang Yuanyuan , Chen Xueling , Geng Xiaoli , He Jianghong , Yang Yi , Zhao Jizong 
Published: November 2022

BackgroundSpinal cord stimulation (SCS) is a promising treatment for patients with disorders of consciousness (DoC); however, the laboratory examinations and different electrodes (permanent #39286 vs. temporary percutaneous #3777, Medtronic, USA) that are associated with postoperative outcomes are unclear. The study aims to study the association between the change in postoperative cerebrospinal fluid (CSF) protein level and improvement in consciousness after SCS in DoC patients and to explore whether different electrodes were associated with elevated CSF protein levels.Materials and methodsA total of 66 DoC patients who received SCS treatment from December 2019 to December 2021 were retrospectively analyzed. Patients were grouped according to their elevated CSF protein level. The clinical characteristics of the patients and SCS stimulation parameters were compared. The preoperative sagittal diameter of the spinal canal is the distance from the midpoint of the posterior border of the vertebral body to the midpoint of the posterior wall of the spinal canal at the level of the superior border of C3. The postoperative sagittal diameter of the spinal canal is the distance from the midpoint of the posterior edge of the vertebral body to the anterior edge of the stimulation electrode. Patients with improved postoperative CRS-R scores greater than 3 or who progressed to the MCS + /eMCS were classified as the improved group and otherwise regarded as poor outcome.ResultsWe found that more DoC patients had elevated CSF protein levels among those receiving SCS treatment with permanent electrodes than temporary percutaneous electrodes (P = 0.001), and elevated CSF protein levels were significantly associated with a reduced sagittal diameter (P = 0.044). In DoC patients receiving SCS treatment, we found that elevated CSF protein levels (P = 0.022) and preoperative diagnosis (P = 0.003) were significantly associated with poor outcomes at 3 months. Logistic regression analysis showed that elevated CSF protein levels were significantly associated with poor outcomes (OR 1.008, 95% CI 1.001–1.016, P = 0.032).ConclusionThe results suggest that reducing the effect of electrode pads on anatomical changes may help improve the outcomes of DoC patients receiving SCS treatment. CSF protein levels are associated with poor postoperative outcomes and whether they are potential biomarkers in DoC patients receiving SCS treatment remain further exploration.
The value of circulating lymphocytic subpopulations in the diagnosis and repair of ischemic stroke patients with dizziness
Authors: Wang Yong , Huang Yichen , Li Sicheng , Lin Jixian , Liu Yang , Gao Yanqin , Zhao Jing 
Published: November 2022

BackgroundTo determine whether dizziness can contribute to stroke as a main cause still remains challenging. This study aims to explore clinical biomarkers in the identification of ischemic stroke patients from people with dizziness and the prediction of their long-term recovery.MethodsFrom January 2018 to June 2019, 21 ischemic stroke patients with a main complaint of dizziness, 84 non-stroke dizziness patients and 87 healthy volunteers were recruited in this study. Then, their peripheral blood samples were collected, and the percentages of circulating lymphocytes T cells, CD4+ T cells, CD8+ T cells, T−/− cells (DNTs), CD4+ regulatory T cells (Tregs), CD8+ Tregs, B cells and regulatory B cells (Bregs) were examined to identify biomarkers with clinical value.ResultsAccording to our data, a significant difference in the DNTs proportion was detected between non-stroke dizziness and ischemic stroke patients with dizziness (p = 0.0009). The Bregs proportion in ischemic stroke patients with dizziness was lower than that in non-stroke dizziness patients (p = 0.035). In addition, the percentage of Bregs and DNTs within lymphocytes in patients’ peripheral blood exhibited a significant negative correlation with stroke occurrence (Bregs, p = 0.039; DNTs, p = 0.046). Moreover, the Bregs and DNTs within lymphocytes were negatively related to participants’ age, while presented a weak relationship with clinical risks like smoking, hypertension, and diabetes. Then, area under the receiver operating characteristic curve (AUC) of Bregs and DNTs together was 0.768, the risk factors and Bregs or DNTs ranged from 0.795 and 0.792, respectively, and the AUC value of risk factors, Bregs and DNTs combination was further increased to 0.815. Furthermore, the Bregs percentage within lymphocytes at admission was also a potential predictor of repair at discharge and the following 3 months.ConclusionBregs and DNTs could be the clinical biomarkers together in the identification of ischemic stroke patients from people with dizziness.
The effects of anesthesia methods and anesthetics on postoperative delirium in the elderly patients: A systematic review and network meta-analysis
Authors: Zhuang Xuhui , He Yuewen , Liu Yurui , Li Jingjing , Ma Wuhua 
Published: November 2022

Study objectivePostoperative delirium (POD) is one of the serious postoperative complications in elderly patients, which is always related to long-term mortality. Anesthesia is often considered a risk factor for POD. This systematic review and network meta-analysis (NMA) aimed to assess the impact of different anesthesia methods and anesthetics on POD.MeasurementsWe searched for studies published in PubMed, Embase, Web of Science, Scopus, and Cochrane Library (CENTRAL) from inception to 18 March 2022. RevMan 5.3 and CINeMA 2.0.0 were used to assess the risk of bias and confidence. Data analysis using STATA 17.0 and R 4.1.2. STATA 17.0 was used to calculate the surface under the cumulative ranking curve (SUCRA) and provide network plots with CINeMA 2.0.0. NMA was performed with R 4.1.2 software gemtc packages in RStudio.Main resultsThis NMA included 19 RCTs with 5,406 patients. In the pairwise meta-analysis results, only regional anesthesia (RA) with general anesthesia (GA) vs. GA (Log OR: –1.08; 95% CI: –1.54, –0.63) were statistically different in POD incidence. In the NMA results, there was no statistical difference between anesthesia methods, and psoas compartment block (PCB) with bupivacaine was superior to the desflurane, propofol, sevoflurane, and spinal anesthesia with bupivacaine of POD occurrence.ConclusionOur study indicated that RA and GA had no significant effect on POD, and there was no difference between anesthesia methods. Pairwise meta-analysis showed that, except for RA with GA vs. GA, the rest of the results were not statistically different. Besides, PCB with bupivacaine may benefit to reduce POD incidence.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/dis play_record.php?ID=CRD42022319499, identifier PROSPERO 2022 CRD42022319499.
Tamper-sensitive pre-formed ReRAM-based PUFs: Methods and experimental validation
Authors: Wilson Taylor , Cambou Bertrand 
Published: November 2022

In this paper, we present the characterization of pre-formed resistive random access memories to design physical unclonable functions and experimentally validate inherent properties such as tamper sensitivity and a self-destroy mode. The physical unclonable functions were tested for repetitive use, temperature effects, and aging. The variations during successive response generation cycles and drift rates are quantized to explore their reliability. We define tamper-sensitivity as the ability to detect tampering attacks. To establish tamper sensitivity, the cells were characterized for higher current sweeps, and the injected current at which they break down is extracted and analyzed to determine suitable operating ranges. Our experimental results show that at least 91% of the cells can generate keys protected by the scheme, while 22% of the sensing elements are triggered. Finally, the cells were characterized for high Voltage sweeps to be able to destroy the physical unclonable functions on-demand when tampering activity is detected. A fixed Voltage of 1.9 V is enough to destroy the entire array.
Autonomic symptoms in migraine: Results of a prospective longitudinal study
Authors: Ray Jason C. , Cheema Sanjay , Foster Emma , Gunasekera Lakshini , Mehta Dwij , Corcoran Susan J. , Matharu Manjit S. , Hutton Elspeth J. 
Published: November 2022

ObjectiveTo assess the prevalence and burden of autonomic symptoms in migraine, and determine the relationship with migraine frequency.BackgroundAutonomic symptoms in migraine have been theorized to occur in the setting of inter-ictal sympathetic hypoactivity and hyper-sensitivity. There is limited data prospectively assessing cranial and extra-cranial autonomic symptoms with a validated instrument, or longitudinal data on the relationship between migraine disease activity and autonomic symptoms.MethodsPatients attending a single tertiary academic center were recruited into a prospective cohort study between September 2020 and June 2022. In addition to standard clinical care, they completed several surveys including the Composite Autonomic Symptom Scale (COMPASS-31) questionnaire, a validated survey of autonomic symptoms.ResultsA total of 43 patients (66.7% female, median age 42, IQR 17) were included in the final analysis. There was a baseline 20 monthly headache days (MHD) (IQR 21.7), and 65.1% of the population had chronic migraine by ICHD-3 criteria. A significantly elevated weighted COMPASS-31 score was reported in 60.5% of respondents (mean 30.3, SD 13.3) at baseline. After 12 months treatment, significant improvements were reported in migraine frequency (median MHD 20–8.7) and disability (median Migraine Disability Assessment Score 67–48), but not in autonomic symptoms (mean score 30.3, SD 11.2).ConclusionAutonomic symptoms were frequently reported in patients with migraine. However, they did not correlate with headache frequency or reversion to episodic frequency. Further study is required to elucidate specific approaches and treatments for autonomic symptoms, and further evaluate the underlying pathophysiological mechanisms.
The effects of conjugated linoleic acid supplementation on lipid profile in adults: A systematic review and dose–response meta-analysis
Authors: Asbaghi Omid , Ashtary-larky Damoon , Naseri Kaveh , Saadati Saeede , Zamani Mohammad , Rezaei Kelishadi Mahnaz , Nadery Maryam , Doaei Saeid , Haghighat Neda 
Published: November 2022

BackgroundThe findings of trials investigating the effect of conjugated linoleic acid (CLA) administration on lipid profile are controversial. This meta-analysis of randomized controlled trials (RCTs) was performed to explore the effects of CLA supplementation on lipid profile.MethodsTwo authors independently searched electronic databases including PubMed, Web of Science, and Scopus until March 2022, in order to find relevant RCTs. The random effects model was used to evaluate the mean and standard deviation.ResultsIn total, 56 RCTs with 73 effect sizes met the inclusion criteria and were eligible for the meta-analysis. CLA supplementation significantly alter triglycerides (TG) (WMD: 1.76; 95% CI: −1.65, 5.19), total cholesterols (TC) (WMD: 0.86; 95% CI: −0.42, 2.26), low-density lipoprotein cholesterols (LDL-C) (WMD: 0.49; 95% CI: −0.75, 2.74), apolipoprotein A (WMD: −3.15; 95% CI: −16.12, 9.81), and apolipoprotein B (WMD: −0.73; 95% CI: −9.87, 8.41) concentrations. However, CLA supplementation significantly increased the density lipoprotein cholesterol (HDL-C) (WMD: −0.40; 95% CI: −0.72, −0.07) concentrations.ConclusionCLA supplementation significantly improved HDL-C concentrations, however, increased concentrations of TG, TC, LDL-C, apolipoprotein A, and apolipoprotein B.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/#recordDetails, identifier: CRD42022331100.
Frailty affects prognosis in patients with colorectal cancer: A systematic review and meta-analysis
Authors: Cai Minghao , Gao Zhongyan , Liao Junyi , Jiang Yuanping , He Yong 
Published: November 2022

BackgroundThe prevalence of colorectal cancer has remained high. Most patients have already developed into the middle and advanced stage when they are diagnosed with colorectal cancer, and a small number of them are accompanied by metastasis. In recent years, frailty has been recognized as an important factor affecting the prognosis of colorectal cancer. The aim of this study was to assess the value of frailty on prognosis in patients with colorectal cancer after treatment.MethodWe systematically searched PubMed, Embase, Web Of Science databases up until March2022. A total of 18 studies were retrieved that met the inclusion criteria, including 9 prospective studies and 9 retrospective studies. Frailty screening tools, proportion of frail patients, and outcomes of colorectal cancer patients after treatment were recorded.Result18 studies were included with a total of 352,535 participants. Regardless of differences in frailty screening and treatment approaches, outcomes for frailty patients were less favorable in all studies. Compared with the non-frail group, the frail group had higher mortality, more serious complications, more postoperative blood transfusions and delirium, and more support outside the home.ConclusionAlthough there is no uniform standard for frailty screening, assessing the frailty of colorectal cancer patients is of great significance for predicting prognosis of patients after treatment.
Purpura with regular shape in an adolescent: Beware of dermatitis artefacta
Authors: Chen Yuhao , Li Lin , Lu Jing 
Published: November 2022

BackgroundPurpura is common in pediatric patients, mostly diagnosed as IgA-related vasculitis (Henoch–Schönlein purpura), idiopathic thrombocytopenic purpura (ITP), and thrombotic thrombocytopenic purpura (TTP). However, in some cases, for example, cases with dermatitis artefacta, it could puzzle a physician or pediatrician for a long time, with great challenges in diagnosis.Case presentationWe present the case of a 13-year-old boy with recurrent painful purpura on both upper limbs. The physical exam was unremarkable, except for right blepharoptosis and scars from burns. The diagnostic tests were normal. Through repeated communication, the patient was finally diagnosed as having dermatitis artefacta, accompanied by underlying psychological problems.ConclusionsBefore dermatitis artefacta was diagnosed, we spent a lot of money and effort on the diagnosis. Therefore, in order to determine the diagnosis as soon as possible and save on unnecessary medical expenses, we propose a rapid process for the diagnosis of purpura of dermatitis artefacta in children.
Neuropharmacological efficacy of metformin for stroke in rodents: A meta-analysis of preclinical trials
Authors: Fu Wenqiao , Tang Yin , Che Xudong , Tan Jiahe , Ma Yinrui , He Zhaohui 
Published: November 2022

Background: Stroke, including ischemic stroke, intracerebral hemorrhage, and subarachnoid hemorrhage (SAH), remains a leading cause of mortality globally. Different stroke subtypes have similar detrimental effects in multiple fields of health. Previous research has shown that metformin plays a neuroprotective role in experimental animal models of stroke; however, a preclinical quantitative analysis on the ability of metformin to treat stroke is still lacking. This meta-analysis evaluates the efficacy of metformin in improving stroke prognosis in rodent models of stroke.Methods: Relevant preclinical trials were retrieved from PubMed, EMBASE, and the Web of Science. The neurological score (NS), brain water content (BWC), infarct size, rotarod test, TUNEL, neuron quantity, microglia quantity, and p-AMPK levels were compared between a control group and a metformin group using the standardized mean difference (SMD) and corresponding confidence interval (CI). Quality was assessed with SYRCLE’s risk of bias tool.Results: Fifteen articles published from 2010 to 2022 were included in the meta-analysis. The metformin group had statistically significant differences compared to the control group in the following aspects: NS (SMD −1.45; 95% CI −2.32, −0.58; p = 0.001), BWC (SMD −3.22; 95% CI −4.69, −1.76; p &lt; 0.0001), infarct size (SMD −2.90; 95% CI −3.95, −1.85; p &lt; 0.00001), rotarod test (SMD 2.55; 95% CI 1.87, 3.23; p &lt; 0.00001), TUNEL (SMD -3.63; 95% CI −5.77, −1.48; p = 0.0009), neuron quantity (SMD 3.42; 95% CI 2.51, 4.34; p &lt; 0.00001), microglia quantity (SMD −3.06; 95% CI -4.69, −1.44; p = 0.0002), and p-AMPK levels (SMD 2.92; 95% CI 2.02, 3.82; p &lt; 0.00001). Furthermore, sensitivity analysis and stratified analysis were conducted for heterogeneous outcome indicators.Conclusion: Overall, metformin treatment improves severe outcomes triggered by stroke. Despite the limitations intrinsic to animal studies, this systematic review may provide a vital reference for future high-quality preclinical trials and clinical use.