bluuebunny/crossref_metadata_2025_split huggingface dataset:
Temperature Profiles and Oxygenation Status in Human Skin and Subcutis Upon Thermography-Controlled wIRA-Hyperthermia
Authors: Thomsen A. R. , Saalmann M. R. , Nicolay N. H. , Grosu A. L. , Vaupel Peter 
Published: May 2022

AbstractEfficacy of wIRA immediately followed by hypofractionated radiation in the treatment of locally recurrent breast cancer and other superficial tumors is documented. A prerequisite for the additive and synergistic radiosensitizing properties of hyperthermia is the assessment of resulting temperatures of tumors and normal tissues. To assess the role of hyperthermia in reversing tumor hypoxia through its effects on local blood flow, oxygen profiles in skin, subcutis, and superficial tumors have been additionally assessed during mild hyperthermia (39–43 °C).Upon wIRA-exposure, skin surface temperatures increased from 35 to 41.6 °C within 5–12 min. Maximum temperatures of 42 °C were found in subepidermal regions, with a steady decline in deeper layers reaching 40.1 °C at a depth of 20 mm. Heating was accompanied by increases in tissue oxygen tensions. Effective hyperthermia levels (≥ 39 °C) were established in depths up to 25 mm. Following wIRA exposure, tissue temperatures returned to pretreatment levels within a few minutes, with the decay time depending on tissue depths, while pO2 values remained on therapeutical levels for 30–60 min postheat, outlasting the period needed for subsequent radiotherapy. Monitoring in the upper dermis layer of skin and recurrent breast cancers confirmed the improved O2 status during wIRA exposure and outlasted the time needed for subsequent radiotherapy.
Thermography-Controlled, Contact-Free wIRA-Hyperthermia Combined with Hypofractionated Radiotherapy for Large-Sized Lesions of Unresectable, Locally Recurrent Breast Cancer
Authors: Notter M. , Thomsen A. R. , Grosu A. L. , Münch K. , Vaupel Peter 
Published: May 2022

AbstractUnresectable locally recurrent breast cancers (LRBCs) lead to life-threatening situations and a tremendous loss of quality of life. Most patients have received radiotherapy (RT) during primary treatment and re-irradiation (re-RT) using standard doses might be denied due to the risk of unacceptable cumulative toxicity. Therefore, an effective tumor control is often abandoned.Mild hyperthermia (39–43 °C), allows for significant reductions in re-RT dose and effective tumor responses with acceptable toxicity even after heavy pretreatment. More than 280 patients have been treated with superficial hyperthermia by water-filtered infrared A (wIRA-HT), which can cover even large lesions. Hyperthermia was immediately followed by hypofractionated re-RT of 5x4 Gy, once a week.Evaluating 201 patients, overall response rate was 94%. 170 patients with macroscopic LRBC were stratified into 4 size classes (rClasses), and detailed response rates are presented. Accordingly, response rates of 31 patients with microscopic disease after resection of LRBC are communicated.RT-related acute and late toxicity was limited to grades 1 and 2. Due to this low toxicity, re-recurrences after CR and new local progression after PR could be re-treated using the same treatment schedule. Real-time thermographic and visual controls have allowed to almost exclude the risk of thermal skin damage.
Weiterführende Optimierung
Authors: Wild Jochen 
Published: May 2022

ZusammenfassungIm Forschungsvorhaben [FVA 467 II] wurden evolventisch basierte Zahnwellenverbindungen nach [DIN 5480] analysiert. Übergeordnetes Ziel hierbei war es, die zu diesem Zeitpunkt gegebenen Möglichkeiten zur Abschätzung der Kerbwirkung, vgl. unter anderem die [DIN 743] sowie die [DIN 5466], zu präzisieren und zu vervollständigen. Um dies zu erreichen, wurden am Institut für Maschinenwesen der Technischen Universität Clausthal experimentelle und am Institut für Maschinenelemente und Maschinenkonstruktion der Technischen Universität Dresden numerische Untersuchungen durchgeführt.
Asymmetry in flavour changing electromagnetic transitions of vector-like quarks
Authors: Balaji Shyam 
Published: May 2022

Abstract
Vector-like quarks have been of interest for a plethora of experimentally motivated reasons and have come under increased investigation recently due to their inclusion to the Standard Model (SM) appreciably improving global fits to several flavour physics and precision electroweak measurements. The addition of vector-like quark singlets breaks the unitarity of the Cabibbo-Kobayashi-Maskawa (CKM) matrix and enables tree-level flavour changing neutral (FCN) vertices. The resulting radiative flavour changing decays of these particles through the electromagnetic transition dipole moment are a key means to study their properties and search for them at experiments like the Large Hadron Collider (LHC). Despite these radiative decays providing such a clean experimental signature, an explicit analytical study of the branching ratios and CP violation resulting from these loop level processes has thus far evaded attention. We provide the formulation for the decay rates and CP asymmetry resulting from a combination of the imaginary components of the loop integrals and complex phases in the quark mixing matrix. We then apply our analytical results to study phenomenology of these states for several global fits pertaining to vector-like isosinglets t′ and b′. We find that clean collider signatures and polarisation observables can be generated for both t′ and b′.
Fate of entanglement between two Unruh-DeWitt detectors due to their motion and background temperature
Authors: Chowdhury Pratyusha , Majhi Bibhas Ranjan 
Published: May 2022

Abstract
We investigate the fate of initial entanglement between two accelerated detectors with respect to an observer attached to one of the detectors. Both (1 + 1) and (1 + 3) spacetime dimensions are being considered here, with the detectors interacting with real massless scalar fields through monopole terms. The investigation is being performed for both non-thermal as well as thermal fields. In general, irrespective of the detectors moving in the same Rindler wedge or opposite wedges, increase of the field temperature reduces the initial entanglement. In all situations, degradation of entanglement is high for high acceleration aA of our observer. Interestingly, the degradation depends on the measure of initial entanglement. For (1 + 1) dimensions, the degradation saturates for small values of aA, whereas the same fluctuates in (1 + 3) dimensions with the decrease of aA. For motions in opposite Rindler wedges, a noticeable feature we observe in (1 + 1) dimensions is that, depending on the strength of initial entanglement, there is a possibility of entanglement harvesting in the system for certain values of the observers’ acceleration. However the same is absent in (1 + 3) dimensions. The whole analysis is operationally different from earlier similar investigations. The thermal equilibrium is satisfied throughout the calculations here, by considering the Wightman functions with respect to the Rindler modes evaluated in the vacuum of Unruh modes, contrary to the use of Minkowski modes.
A genome on shaky ground: exploring the impact of mitochondrial DNA integrity on Parkinson’s disease by highlighting the use of cybrid models
Authors: Lang Martin , Grünewald Anne , Pramstaller Peter P. , Hicks Andrew A. , Pichler Irene 
Published: May 2022

AbstractMitochondria play important roles in the regulation of key cellular processes, including energy metabolism, oxidative stress response, and signaling towards cell death or survival, and are distinguished by carrying their own genome (mtDNA). Mitochondrial dysfunction has emerged as a prominent cellular mechanism involved in neurodegeneration, including Parkinson’s disease (PD), a neurodegenerative movement disorder, characterized by progressive loss of dopaminergic neurons and the occurrence of proteinaceous Lewy body inclusions. The contribution of mtDNA variants to PD pathogenesis has long been debated and is still not clearly answered. Cytoplasmic hybrid (cybrid) cell models provided evidence for a contribution of mtDNA variants to the PD phenotype. However, conclusive evidence of mtDNA mutations as genetic cause of PD is still lacking. Several models have shown a role of somatic, rather than inherited mtDNA variants in the impairment of mitochondrial function and neurodegeneration. Accordingly, several nuclear genes driving inherited forms of PD are linked to mtDNA quality control mechanisms, and idiopathic as well as familial PD tissues present increased mtDNA damage. In this review, we highlight the use of cybrids in this PD research field and summarize various aspects of how and to what extent mtDNA variants may contribute to the etiology of PD.
Change your Angle of View
Authors: Luecking Hannes , Hoelter Philip , Lang Stefan , Schmidt Manuel , Eisenhut Felix , Doerfler Arnd 
Published: May 2022

Abstract
Background
Artifacts from surrounding bony structures, especially from the petrous bones, regularly impair soft tissue computed tomography (CT) imaging of the middle and posterior fossa. This affects flat-panel CT in particular. Sinusoidal movement of the C‑arm during acquisition (i.e. craniocaudal tilting along with semicircular rotation) is supposed to reduce artifacts, thus enhancing soft tissue imaging quality.

Methods
In the work-up of ischemic stroke or subarachnoid hemorrhage 40 patients underwent multi-slice CT (MS-CT) and either plain circular (cFP-CT; n = 20) or sinusoidal (sFP-CT; n = 20) flat-panel CT within a short interval. Two independent readers analyzed MS-CT and FP-CT datasets for recognizability of eight different brain structures and three typical types of artifacts according to a predetermined score.

Results
Interrater reliability was moderate for cFP-CT (κ = 0.575) and good to very good for ratings of MS-CT and sFP-CT (κ = 0.651 to κ = 1). MS-CT was rated to be significantly better than cFP-CT and sFP-CT (p < 0.0001) in the overall score. Yet, sFP-CT was rated to be significantly superior to cFP-CT (overall p < 0.0001) regarding most anatomical regions and petrous bone artifacts.

Conclusion
Compared to a standard circular protocol, sinusoidal C‑arm movement in cranial FP-CT can significantly reduce artifacts in the posterior fossa and, moreover, can improve visualization of most supratentorial and infratentorial anatomical structures.
„Rebound pain“ – von der Definition bis zur Therapie
Authors: Streb Timo , Schneider Alexander , Wiesmann Thomas , Riecke Jenny , Schubert Ann-Kristin , Dinges Hanns-Christian , Volberg Christian 
Published: May 2022

Zusammenfassung
Hintergrund
Rebound pain als Nebenwirkung einer Regionalanästhesie ist ein übermäßiges Schmerzempfinden nach Abklingen der Wirkung der lokalen Betäubung, welches deutlich über den normalen Wundschmerz nach einer Operation hinausgeht. Dieses Phänomen rückt seit ca. 10 Jahren stärker in den Fokus der Forschung. Die konkreten Ursachen sind bisher unklar, und es existieren auch noch keine zielgerichteten Therapieempfehlungen.

Ziel der Arbeit
Dieser Übersichtsartikel soll der Leserschaft einen Überblick über den aktuellen Stand der Forschung geben. Es werden die Theorien zur Pathophysiologie vorgestellt und Prophylaxe- sowie Behandlungsstrategien erläutert.

Material und Methoden
Für diese Übersichtsarbeit wurden die von 2005 bis Mai 2021 auf PubMed erschienenen Publikationen zum Thema Rebound pain durchgesehen und die Definitionen der Autoren zu Rebound pain sowie die Annahmen zur Pathophysiologie und Therapieempfehlungen zusammengefasst.

Ergebnisse und Diskussion
Insgesamt wurden 22 Originalarbeiten im Hinblick auf die Definition von Rebound pain, die Annahme der Entstehung sowie Therapieoptionen ausgewertet. Dabei zeigt sich, dass keine einheitliche Definition existiert, die Pathophysiologie nicht eindeutig geklärt ist und zum aktuellen Zeitpunkt auch noch keine klaren Empfehlungen zu Prophylaxe sowie Therapie gegeben werden können.
Radiologische Assistentenfortbildung während der COVID-19-Pandemie
Authors: Thormann Maximilian , Lerach Teresa , Gottschling Sebastian , Omari Jazan , Pech Maciej , Surov Alexey 
Published: May 2022

ZusammenfassungKontaktbeschränkungen und Abstandsregeln haben die klinische Weiterbildung vor große Herausforderungen gestellt. Innovative und interaktive Konzepte sind notwendig, um die Weiterbildung auch in Zeiten von Corona aufrechtzuerhalten. In der aktuellen Literatur sind Lehrkonzepte für Ärztinnen und Ärzte in der Facharztweiterbildung jedoch unterrepräsentiert. In dieser Arbeit wird ein onlinebasiertes Fortbildungskonzept in der Radiologie vorgestellt, das die klassische Fallvorstellung in ein dreiphasiges, interaktives Lernmodell umgestaltet. Dieses besteht aus einer selbstständigen Fallbearbeitung mit Anknüpfung an bestehendes Wissen, gefolgt von einer Falldiskussion und gezielten Fragen sowie Feedback durch die teilnehmenden Oberärztinnen und Oberärzte. Nach 12 Monaten erfolgte eine fragebogenbasierte Evaluation durch die Weiterbildungsassistentinnen und -assistenten. Hierbei zeigte sich, dass eine deutliche Mehrheit der Teilnehmerinnen und Teilnehmer das Fortbildungskonzept positiv hinsichtlich seines Schweregrades, der Repräsentativität für die klinische Tätigkeit sowie der Relevanz für den Facharzt bewerteten. Ebenso ergaben sich Erkenntnisse hinsichtlich der zukünftigen Gestaltung des Konzepts in Bezug auf Dauer, Modalität der zu besprechenden Bildgebungsverfahren und Häufigkeit. Alle Befragten gaben an, vom Format profitiert zu haben. Onlinebasierte Fortbildungskonzepte können demnach einen relevanten Beitrag zur Weiterbildung von Assistenzärztinnen und -ärzten leisten und stellen eine adäquate Alternative bzw. Erweiterung analoger Fortbildungskonzepte dar.
Composite forecasting of vast-dimensional realized covariance matrices using factor state-space models
Authors: Hartkopf Jan Patrick 
Published: May 2022

AbstractWe propose a dynamic factor state-space model for the prediction of high-dimensional realized covariance matrices of asset returns. Using a block LDL decomposition of the joint covariance matrix of assets and factors, we express the realized covariance matrix of the individual assets similar to an approximate factor model. We model the individual parts, i.e., the factor and residual covariances as well as the factor loadings, independently via a tractable state-space approach. This results in closed-form Matrix-F predictive densities for the distinct covariance elements and Student’s t predictive densities for the factor loadings. In an out-of-sample forecasting and portfolio selection exercise we compare the performance of the proposed factor model under different specifications of the residual dynamics. These includes block diagonal residuals based on the GICS sector classifications and strict diagonality assumptions as well as combinations of both using linear shrinkage. We find that the proposed model performs very well in an empirical application to realized covariance matrices for 225 NYSE-traded stocks using the well-known Fama–French factors and sector-specific factors represented by exchange traded funds.
Corruption and partisan polarization: evidence from the European Union
Authors: Apergis Nicholas , Pinar Mehmet 
Published: May 2022

AbstractRecent work documents that even though partisan polarization may have detrimental economic and social outcomes, polarized societies lead to better governance and less corruption. However, the effect of corruption on partisan polarization has been mostly ignored by the literature. By using various measures of partisan polarization and corruption, this paper demonstrates that corrupt behaviours are associated with more partisan polarization in the European Union, indicating that a stronger presence of corruption leads to higher partisan polarization. The findings are robust to the use of different polarization measures, methodologies, and a battery of control variables. This paper’s main finding, increased corruption leading to increased partisan polarization, provides another important mechanism beyond the standard socio-economic factors that led to the current rise in support of parties opposing to European Union and rise of populist parties in European Union. Polarized societies tend to generate inefficient economic outcomes and the alleviation of corruption could improve economic outcomes by decreasing partisan polarization.
The Generalized Langevin Equation in Harmonic Potentials: Anomalous Diffusion and Equipartition of Energy
Authors: Didier Gustavo , Nguyen Hung D. 
Published: May 2022

AbstractWe consider the generalized Langevin equation (GLE) in a harmonic potential with power law decay memory. We study the anomalous diffusion of the particle’s displacement and velocity. By comparison with the free particle situation in which the velocity was previously shown to be either diffusive or subdiffusive, we find that, when trapped in a harmonic potential, the particle’s displacement may either be diffusive or superdiffusive. Under slightly stronger assumptions on the memory kernel, namely, for kernels related to the broad class of completely monotonic functions, we show that both the free particle and the harmonically bounded GLE satisfy the equipartition of energy condition. This generalizes previously known results for the GLE under particular kernel instances such as the generalized Rouse kernel or (exactly) a power law function.
Harnessing the liver to induce antigen-specific immune tolerance
Authors: Gottwick Cornelia , Carambia Antonella , Herkel Johannes 
Published: May 2022

AbstractAutoimmune diseases develop when the adaptive immune system attacks the body’s own antigens leading to tissue damage. At least 80 different conditions are believed to have an autoimmune aetiology, including rheumatoid arthritis, type I diabetes, multiple sclerosis or systemic lupus erythematosus. Collectively, autoimmune diseases are a leading cause of severe health impairment along with substantial socioeconomic costs. Current treatments are mostly symptomatic and non-specific, and it is typically not possible to cure these diseases. Thus, the development of more causative treatments that suppress only the pathogenic immune responses, but spare general immunity is of great biomedical interest. The liver offers considerable potential for development of such antigen-specific immunotherapies, as it has a distinct physiological capacity to induce immune tolerance. Indeed, the liver has been shown to specifically suppress autoimmune responses to organ allografts co-transplanted with the liver or to autoantigens that were transferred to the liver. Liver tolerance is established by a unique microenvironment that facilitates interactions between liver-resident antigen-presenting cells and lymphocytes passing by in the low blood flow within the hepatic sinusoids. Here, we summarise current concepts and mechanisms of liver immune tolerance, and review present approaches to harness liver tolerance for antigen-specific immunotherapy.
Ultrastructural and biochemical classification of pathogenic tau, α-synuclein and TDP-43
Authors: Tarutani Airi , Adachi Tadashi , Akatsu Hiroyasu , Hashizume Yoshio , Hasegawa Kazuko , Saito Yuko , Robinson Andrew C. , Mann David M. A. , Yoshida Mari , Murayama Shigeo , Hasegawa Masato 
Published: May 2022

AbstractIntracellular accumulation of abnormal proteins with conformational changes is the defining neuropathological feature of neurodegenerative diseases. The pathogenic proteins that accumulate in patients' brains adopt an amyloid-like fibrous structure and exhibit various ultrastructural features. The biochemical analysis of pathogenic proteins in sarkosyl-insoluble fractions extracted from patients’ brains also shows disease-specific features. Intriguingly, these ultrastructural and biochemical features are common within the same disease group. These differences among the pathogenic proteins extracted from patients’ brains have important implications for definitive diagnosis of the disease, and also suggest the existence of pathogenic protein strains that contribute to the heterogeneity of pathogenesis in neurodegenerative diseases. Recent experimental evidence has shown that prion-like propagation of these pathogenic proteins from host cells to recipient cells underlies the onset and progression of neurodegenerative diseases. The reproduction of the pathological features that characterize each disease in cellular and animal models of prion-like propagation also implies that the structural differences in the pathogenic proteins are inherited in a prion-like manner. In this review, we summarize the ultrastructural and biochemical features of pathogenic proteins extracted from the brains of patients with neurodegenerative diseases that accumulate abnormal forms of tau, α-synuclein, and TDP-43, and we discuss how these disease-specific properties are maintained in the brain, based on recent experimental insights.
Pharyngolaryngeal semiology and prognostic factors in multiple system atrophy
Authors: El Fassi N. , Gallois Y. , Crestani S. , Fichaux-Bourrin P. , Ory F. , Fabbri M. , Pavy le Traon A. , Woisard V. 
Published: May 2022

Abstract
Introduction
Multiple system atrophy (MSA) is a rare degenerative neurological disorder in adults. It induces parkinsonian and/or cerebellar syndrome associated with dysautonomia. Pharyngolaryngeal symptoms are common. Our aim is to describe the Pharyngolaryngeal semiology on one hand, and to ascertain whether the presence of these symptoms represents a prognostic factor for MSA on the other.

Methods
Thus, we carried out a retrospective, single-centre study, on a cohort receiving care at the centre of reference for MSA. The patients were referred for otorhinolaryngology assessment. The data was collected over the year 2020 with the help of computer software from the university hospital centre (UHC). Firstly, we described the Pharyngolaryngeal semiology specific to MSA by questioning patients, and by the results of nasofibroscopic examinations and swallowing tests. We then used multivariate analysis of variance to describe the prognostic factors of MSA progression (in UMSARS I and II points per month of progression) and survival (number of years between the first symptoms and death).

Results
This study included a hundred and one patients and made it possible to define a Pharyngolaryngeal semiology profile of MSA, which is: a reduction in laryngeal mobility (primarily vocal cord abduction defects), abnormal movements (particularly at rest or when initiating a movement) and a defect in the protection mechanisms of the upper airways. The swallowing difficulties are moderate and the main mechanisms are delayed pharyngeal swallow and/or an oro-pharyngeal transport defect. In the multivariate analyses, the contributing factors are laryngeal anomalies, modification of solid food to fluid food and nutritional complication.

Conclusion
ENT specialists should pay close attention to problems in the Pharyngolaryngeal dynamic and then consider a neurological cause. They can also itemize the clinical factors that could have a negative effect on the prognosis of the patient with MSA. Indeed, early detection makes it possible to provide care for respiratory and nutritional complications.