bluuebunny/crossref_metadata_2025_split huggingface dataset:
Monitoring and Regulation of Indoor Conditions
Authors: Stojkov Marinko , Crnogorac Krešimir , Alinjak Tomislav , Crnogorac Bernarda 
Published: February 2022

This paper presents research of energy performance analysis performed by Building Energy Management System (BEMS). BEMS is a system/platform integrated with building and it is an enormous improvement in a process to develop nearly zero energy buildings (nZEB). Near zero energy consumption stands for energy efficient idea of energy independent buildings for their function during their life time. Here, BEMS with function of monitoring and regulation of cooling energy demand is developed. BEMS regulates function of ventilation fan in area below tin roof and improves working conditions by inside building temperature reduction during summer period. Described technical solution is designed inside RESCUE IPA CBC project.
Generación de bienestar en salud en América Latina y el Caribe: Un modelo DEA en presencia de bad outputs
Authors: Ayvar Campos Francisco Javier , Zamora Torres América Ivonne 
Published: February 2022

América Latina y el Caribe durante el período 1980-2015 vivió una serie de transformaciones estructurales que incidió notablemente en la dinámica de sus principales indicadores socioeconómicos. Es así como el producto interno bruto, la inversión extranjera directa, la formación bruta de capital, el gasto público, las exportaciones, las importaciones y el personal ocupado crecieron notablemente en estos arios. Sin embargo, indicadores como la pobreza, inequidad, marginación y migración siguieron la misma tendencia; consecuencia de la desigualdad entre los países y al interior de los mismos. Es así como a pesar de ser una región económicamente dinámica e inserta en los modelos económicos de desarrollo que siguen los países desarrollados está integrada por economías emergentes y con bajos niveles de desarrollo humano (Banco Mundial, 2018; PNUD, 2018).
El objetivo del documento es determinar qué tan eficiente fueron 29 economías emergentes de la región de América Latina y el Caribe en la utilización de sus recursos para generar bienestar en salud y a la par reducir la desnutrición durante el período 1980-2015. Para alcanzar dicho objetivo se parte de reconocer que el desarrollo humano es un proceso que permite que los individuos, y por ende la sociedad, alcance altos niveles de bienestar (Griffin, 2001). Siendo la salud un elemento clave para obtener dicho bienestar, ya que se encuentra muy vinculado con las otras dimensiones del desarrollo humano (Casas-Zamora, 2002). De esta forma, se considera que incidir en el uso eficiente de los recursos para generar bienestar en salud y reducir a la vez la desnutrición contribuirá a acrecentar el bienestar social de las economías emergentes de América Latina y el Caribe.
La técnica que se aplicó para medir la eficiencia fue el Análisis Envolvente de Datos (DEA) (Cooper, Seiford & Tone, 2007). Es así como se desarrolló un modelo de eficiencia en el que se estableció como output la esperanza de vida al nacer y como bad output la población en condiciones de desnutrición. Producto de la revisión de la literatura y de pruebas factoriales se establecieron como inputs del modelo la cantidad de médicos
disponibles y el gasto público en salud. El modelo DEA se orientó al output y se consideraron rendimientos variables a escala. Con la finalidad de identificar la evolución de la productividad y la eficiencia en el período estudiado, considerando la presencia de bad outputs, se calculó el índice Malmquist-Luenberger.
El documento se encuentra estructurado en cuatro apartados. En el primero, se abordan las principales características del desarrollo humano y la salud en América Latina y el Caribe; en el segundo, se presentan los argumentos teóricos del bienestar y la salud; en el tercero, se desarrollan los elementos teórico-metodológicos del Análisis Envolvente de Datos; en el cuarto, se presentan los resultados obtenidos del modelo de eficiencia; finalmente, se exponen las principales conclusiones del trabajo.
Performance of Two Aman Rice Varieties Using Varying Plant Density in the Northeastern Region Of Bangladesh
Authors: Ahmed F , Islam MN , Bhuyan MHMB 
Published: February 2022

The experiment was conducted to assess the performance of two popular rice varieties with varying spacing at a farmer's field in Darbost union of Jaintapur Upazila under the Sylhet district of Bangladesh during aman season 2016. Two aman rice varieties (BRRI dhan34 and Binadhan-17), and four levels of plant density (15×10 cm, 20×10 cm, 20×15 cm, and 25×15 cm) were tested in a factorial randomized complete block design (RCBD) with three replications. The results indicated that yield and yield attributes of rice differed significantly due to varieties, spacing, and their interaction. It was recorded that var. Binadhan-17 showed maximum flag leaf length (34.33 cm), maximum number of filled grains m−2 (27855), maximum grain weight m−2 (654.58) contributed to increase grain yield (6.55 t ha−1) in closer spacing (20×10 cm), which ultimately increased grain yield. Therefore, the results of the present study suggested that rice var. Binadhan-17 could be transplanted at 20×10 cm spacing for getting maximum yield (6.55 t ha−1) in northeastern region of Bangladesh.
Bangladesh Agron. J. 2021, 24(2): 1-12
Light Interception and Productivity of Maize Intercropped With Legumes in Kharif Season
Authors: Naher Q , Hossain MA 
Published: February 2022

The experiment was carried out at the Bangladesh Agricultural Research institute, Joydebpur, Gazipur during 2012 to evaluate the intercepted PAR in maize intercropped withlegumein comparison to monoculture for better weed suppression, productivity and economic benefits in kharif season. There were 17 treatments in the experiment viz., T1= Sole maize (no weeding), T2= Maize + Mungbean (no weeding), T3= Maize + Mungbean (weeding at 20 DAE), T4= Maize + Mungbean (weeding at 40 DAE), T5= Maize + Mungbean (weeding at 20 and 40 DAE), T6= Maize + Soybean (no weeding), T7= Maize + Soybean (weeding at 20 DAE), T8= Maize + Soybean (weeding at 40 DAE), T9= Maize + Soybean (weeding at 20 and 40 DAE), T10= Maize + Blackgram (no weeding), T11= Maize + Blackgram( weeding at 20 DAE), T12= Maize + Blackgram( weeding at 40 DAE), T13= Maize + Blackgram (weeding at 20 and 40 DAE) T14 =Sole maize (weed free), T15= Sole Mungbean (weed free), T16=Sole Soybean (weed free) and T17= Sole Blackgram (weed free).The results showed that PAR was significantly affected by cropping system, where it was higher in intercropping systems compared to sole crop . Regarding weed control, intercrops were more effective than sole crops and it was related to lower availability of PAR for weeds in intercropping systems. The highest grain yield (8.05 t ha-1). was obtained from weed free sole maize Among all intercropping, maize + mungbean along with two hand weeding gave the highest yield (maize: 7.18 t ha-1; 572.6 kg ha-1 mungbean), maize equivalent yield (MEY) = 12.49t ha-1and BCR = 2.84). From the study it can be concluded that maize mungbean intercropping with two hand weedings at 20 and 40 DAE would be the best in reducing weed growth, producing maximum yield and net return in intercropping systems under kharif season.
Bangladesh Agron. J. 2021, 24(2): 137-149
PEMBERDAYAAN WANITA MELALUI USAHA KRUPUK LELE ORGANIK DI DESA SUMBERNGEPOH, LAWANG KABUPATEN MALANG
Authors: Suhartatik Suhartatik , Purwati Titik , Bangun Wilyati Agustina 
Published: February 2022

Women's empowerment is the focus of this community service activity in partnership with mothers from the Krupuk Business Group, Ibu Mujiati and Ibu Tuni. The purpose of this activity is to solve the problems faced by the organic catfish cracker business group partners in Sumberngepoh Village, Lawang, Malang Regency, in terms of production and management aspects. The targets to be achieved from this activity are training and additional production equipment for partners as an effort to empower the community.
Method of program implementation This activity goes through three stages, namely the planning stage, the implementation stage and the evaluation stage. The results achieved from this activity are: 1) a solution to production problems by adding/procuring new production equipment and raw materials for making organic catfish crackers; 2) the existence of solutions to management problems by holding management training which includes production, marketing, sanitation and hygiene. The final result shows that there are indicators of success with increased knowledge of partners and productivity of organic catfish crackers that increase with management training.
SOSIALISASI MENINGKATKAN IMUNITAS KESEHATAN IBU DI MASA PANDEMI DI LINGKUNGAN RW 07 KARANGBESUKI KOTA MALANG
Authors: Bangun Wilyati Agustina , Suhartatik Suhartatik , Purwati Titik 
Published: February 2022

In 2020, the outbreak of a new virus that shocked the world, namely Coronavirus Disease (Covid 19). There are some ways to survive from the pandemic such as obeying government instructions and increase the immunity of body. The purpose of the community service is to provide counseling or social outreach, as well as provide education related to improving maternal health and immunity during the pandemic. The activities of Community Service cover several stages. First, coordinating about the Community Service Agenda with the Head of Neighborhood and Citizens Associations. Second, the executor team prepare some materials of socialization. Third, the executor team conduct the educational outreach. In conclusion, improving maternal health and immunity can be reached by consuming healty food, providing healthy life, and avoiding stress.
Dysregulated Peripheral Invariant Natural Killer T Cells in Plaque Psoriasis Patients
Authors: Hu Yifan , Chen Youdong , Chen Zeyu , Zhang Xilin , Guo ChunYuan , Yu ZengYang , Xu Peng , Sun Lei , Zhou Xue , Gong Yu , Yu Qian , Shi Yuling 
Published: February 2022

Background: Psoriasis is a common immune-mediated skin disease that involves T-cell-mediated immunity. Invariant natural killer T (iNKT) cells are a unique lymphocyte subpopulation that share properties and express surface markers of both NK cells and T cells. Previous reports indicate that iNKT cells regulate the development of various inflammatory diseases. IL-17 is a key cytokine in the pathogenesis of psoriasis and a key therapeutic target. Secukinumab is a fully human IgG1κ antibody that targets IL-17A, thereby antagonizing the biological effects of IL-17.Objective: To explore the expression of iNKT cells in psoriasis patients and the effect of secukinumab on them.Methods: We examined the frequencies of iNKT cells, Tregs, naïve and memory CD4+and CD8+T cells in the PBMCs as well as their cytokine production in a cohort of 40 patients with moderate-to-severe plaque psoriasis and 40 gender- and age-matched healthy controls. We further collected peripheral blood of another 15 moderate-to-severe plaque psoriasis patients who were treated with secukinumab and evaluated the proportion of iNKT cells in the PBMCs at baseline and week 12.Results: The frequencies of conventional CD4+ T cells, CD8+ T cells, and Tregs in the PBMCs were comparable between psoriasis patients and healthy controls, but the frequencies of Th17 cells, Tc1 cells and Tc17 cells were increased in psoriasis patients. The frequency of peripheral iNKT cells and CD69+iNKT cells was significantly decreased in psoriasis patients. Both iNKT2 cells and iNKT17 cells were increased in psoriasis patients, but the ratio of iNKT2 cells vs iNKT17 cells was significantly reduced in psoriasis patients. After receiving secukinumab, the proportion of iNKT cells in the PBMCs of patients was increased, while the proportion of iNKT17 cells was decreased.Conclusion: Dysregulated iNKT cells may be involved in the pathogenesis of psoriasis and secukinumab may play a regulatory role on iNKT cells.
Plasmodium Circumsporozoite Protein Enhances the Efficacy of Gefitinib in Lung Adenocarcinoma Cells by Inhibiting Autophagy via Proteasomal Degradation of LC3B
Authors: Lu Xiao , Zhang Jiao , Li Yan-Qi , Liu Quan-Xing , Zhou Dong , Deng Xu-Feng , Qiu Yuan , Chen Qian , Li Man-Yuan , Liu Xiao-Qing , Dai Ji-Gang , Zheng Hong 
Published: February 2022

Background: Almost all lung adenocarcinoma (LUAD) patients with EGFR mutant will develop resistance to EGFR-TKIs, which limit the long-term clinical application of these agents. Accumulating evidence shows one of the main reasons for resistance to EGFR-TKIs is induction of autophagy in tumor cells. Our previous study found that circumsporozoite protein (CSP) in Plasmodium can suppress autophagy in host hepatocytes. However, it is unknown whether CSP-mediated inhibition of autophagy could improve the anti-tumor effect of EGFR-TKIs.Methods: We constructed A549 and H1975 cell lines with stable overexpression of CSP (OE-CSP cells). CCK-8, Lactate Dehydrogenase (LDH), flow cytometry, and colony analysis were performed to observe the effect of CSP overexpression on cell viability, apoptosis rate, and colony formation ratio. The sensitizing effect of CSP on gefitinib was evaluated in vivo using a subcutaneous tumor model in nude mice and immunohistochemical assay. The role of CSP in regulation of autophagy was investigated by laser confocal microscopy assay and western blotting. A transcriptome sequencing assay and real-time polymerase chain reaction were used to determine the levels of mRNA for autophagy-related proteins. Cycloheximide (CHX), MG132, TAK-243, and immunoprecipitation assays were used to detect and confirm proteasomal degradation of LC3B.Results: OE-CSP A549 and H1975 cells were more sensitive to gefitinib, demonstrating significant amounts of apoptosis and decreased viability. In the OE-CSP group, autophagy was significantly inhibited, and there was a decrease in LC3B protein after exposure to gefitinib. Cell viability and colony formed ability were recovered when OE-CSP cells were exposed to rapamycin. In nude mice with xenografts of LUAD cells, inhibition of autophagy by CSP resulted in suppression of cell growth, and more marked apoptosis during exposure to gefitinib. CSP promoted ubiquitin-proteasome degradation of LC3B, leading to inhibition of autophagy in LUAD cells after treatment with gefitinib. When LUAD cells were treated with ubiquitin activating enzyme inhibitor TAK-243, cell viability, apoptosis, and growth were comparable between the OE-CSP group and a control group both in vivo and in vitro.Conclusion: CSP can inhibit gefitinib-induced autophagy via proteasomal degradation of LC3B, which suggests that CSP could be used as an autophagy inhibitor to sensitize EGFR-TKIs.
The Rational Design of a Financially Viable Microbial Electrolysis Cell for Domestic Wastewater Treatment
Authors: Aiken Daniel C. , Curtis Thomas P. , Heidrich Elizabeth S. 
Published: February 2022

Microbial electrolysis cells (MECs) are yet to achieve commercial viability. Organic removal rates (ORR) and capital costs dictate an MEC’s financial competitiveness against activated sludge treatments. We used numerical methods to investigate the impact of acetate concentration and the distance between opposing anodes’ surfaces (anode interstices width) on MEC cost-performance. Numerical predictions were calibrated against laboratory observations using an evolutionary algorithm. Anode interstices width had a non-linear impact on ORR and therefore allowable cost. MECs could be financially competitive if anode interstices widths are carefully controlled (2.5 mm), material costs kept low (£5–10/m2-anode), and wastewater pre-treated, using hydrolysis to consistently achieve influent acetate concentrations &gt;100 mg-COD/l.
Insulin Resistance Promotes the Formation of Aortic Dissection by Inducing the Phenotypic Switch of Vascular Smooth Muscle Cells
Authors: Zheng Hui , Qiu Zhihuang , Chai Tianci , He Jian , Zhang Yuling , Wang Chaoyun , Ye Jianqiang , Wu Xiaohui , Li Yumei , Zhang Li , Chen Liangwan 
Published: February 2022

BackgroundInsulin resistance (IR) plays a key role in the development of type 2 diabetes mellitus (T2DM) and is one of its most important characteristics. Previous studies have shown that IR and T2DM were independent risk factors for a variety of cardiovascular and cerebrovascular diseases. However, there are few studies on the relationship between IR and aortic dissection (AD). The goal of this research was to find evidence that IR promotes the occurrence of AD.MethodsThrough the statistical analysis, we determined the proportion of glycosylated hemoglobin (HbA1c) abnormalities (HbA1c &gt; 5.7) in people with acute thoracic aortic dissection (ATAD) and compared the difference of messenger RNA (mRNA) and protein expression of GluT1 in the thoracic aorta of normal people and those with ATAD to find evidence that IR is a causative factor in AD. The mouse model of IR and AD and the IR model of human aortic vascular smooth muscle cells (HA-VSMC) were established. Real time-PCR (RT-PCR) and Western blotting were used to study the mRNA and protein expression. Hematoxylin and eosin (H&amp;E), Masson, and elastic fiber staining, and immunofluorescence were used to study the morphological structure.ResultsThe proportion of HbA1c abnormalities in patients with ATAD was 59.37%, and the mRNA and protein expression of GluT1 were significantly lower than that in normal people. Fasting glucose concentration (FGC), serum insulin concentration (SIC), and the homeostasis model assessment of insulin resistance (HOMA-IR) of mice was obviously increased in the high-fat diet group and the protein expressions of Glut1 and GluT4 were reduced, indicating that the mouse IR model was successfully established. The incidence of AD was different between the two groups (IR: 13/14, Ctrl: 6/14), and the protein expression of MMP2, MMP9, and OPN were upregulated and SM22 and α-SMA were downregulated in mice. The expressions of mRNA and protein of GluT1 and SM22 in HA-VSMCs with IR were reduced and OPN was increased.ConclusionCombined results of clinical findings, mouse models, and cell experiments show that IR induced the phenotypic switching of vascular smooth muscle cells (VSMCs) from contractile to synthetic, which contributes to the occurrence of AD. It provides a basis for further research on the specific mechanism of how IR results in AD and a new approach for the prevention and treatment of AD.
Age-Related Electrocardiographic Characteristics of Male Junior Soccer Athletes
Authors: Cavarretta Elena , Sciarra Luigi , Biondi-Zoccai Giuseppe , Maffessanti Francesco , Nigro Antonia , Sperandii Fabio , Guerra Emanuele , Quaranta Federico , Fossati Chiara , Peruzzi Mariangela , Pingitore Annachiara , Stasinopoulos Dimitrios M. , Rigby Robert A. , Adorisio Rachele , Saglietto Andrea , Calò Leonardo , Frati Giacomo , Pigozzi Fabio 
Published: February 2022

IntroductionVery limited data exist on normal age-related ECG variations in adolescents and no data have been published regarding the ECG anomalies induced by intensive training, which are relevant in pre-participation screening for sudden cardiac death prevention in the adolescent athletic population. The purpose of this study was to establish normal age-related electrocardiographic measurements (P wave duration, PR interval, QRS duration, QT, and QTc interval) grouped according to 2-year age intervals.MethodsA total of 2,151 consecutive healthy adolescent Soccer athletes (trained for a mean of 7.2 ± 1.1 h per week, 100% male Caucasians, mean age 12.4 ± 1.4 years, range 7–18) underwent pre-participation screening, which included ECG and transthoracic echocardiography in a single referral center.ResultsTheir heart rate progressively slowed as age increased (p &lt; 0.001, ranging from 80.8 ± 13.2 to 59.5 ± 10.2 bpm), as expected. The P wave, PR interval, and QRS duration significantly increased in older age classes (p = 0.019, p = 0.001, and p &lt; 0.001, respectively), and after Bonferroni's correction, the difference remained significant in all age classes for QRS duration. The QTc interval diminished progressively with increasing age (p = 0.003) while the QT interval increased progressively (p &lt; 0.001).ConclusionsSignificant variations in the normal ECG characteristics of young athletes exist between different age groups related to increasing age and training burden, thus, age-specific reference values could be adopted, as already done for echocardiographic measurements, and may help to further discriminate potentially pathologic conditions.
Understanding Clinician Macrocognition to Inform the Design of a Congenital Heart Disease Clinical Decision Support System
Authors: Assadi Azadeh , Laussen Peter C. , Freire Gabrielle , Trbovich Patricia 
Published: February 2022

Background and ObjectivesChildren with congenital heart disease (CHD) are at risk of deterioration in the face of common childhood illnesses, and their resuscitation and acute treatment requires guidance of CHD experts. Many children with CHD, however, present to their local emergency departments (ED) with gastrointestinal and respiratory symptoms that closely mimic symptoms of CHD related heart failure. This can lead to incorrect or delayed diagnosis and treatment where CHD expertise is limited. An understanding of the differences in cognitive decision-making processes between CHD experts and ED physicians can inform how best to support ED physicians when treating CHD patients.MethodsCardiac intensivists (CHD experts) and pediatric emergency department physicians (ED physicians) in a major academic cardiac center were interviewed using the critical decision method. Interview transcripts were coded deductively based on Schubert and Klein's macrocognitive frameworks and inductively to allow for new or modified characterization of dimensions.ResultsIn total, 6 CHD experts and 7 ED physicians were interviewed for this study. Although both CHD experts and ED physicians spent a lot of time sensemaking, their approaches to sensemaking differed. CHD experts reported readily recognizing the physiology of complex congenital heart disease and focused primarily on ruling out cardiac causes for the presenting illness. ED physicians reported a delay in attributing the signs and symptoms of the presenting illness to congenital heart disease, because these clinical findings were often non-specific, and thus explored different diagnoses. CHD experts moved quickly to treatment and more time anticipating potential problems and making specific contingency plans, while ED physicians spent more time gathering a range of data prior to arriving at a diagnosis. These findings were then applied to develop a prototype web-based decision support application for patients with CHD.ConclusionThere are differences in the cognitive processes used by CHD experts and ED physicians when managing CHD patients. An understanding of differences in the cognitive processes used by CHD experts and ED physicians can inform the development of potential interventions, such as clinical decision support systems and training pathways, to support decision making pertaining to the acute treatment of pediatric CHD patients.