bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development and Validation of a Health Information System for Assistance and Research in Gestational Trophoblast Disease
Authors: Martins Jaqueline , Bandiera-Paiva Paulo , Neto Antonio Rodrigues Braga , de Carvalho Lucas Ribeiro Borges , Padrini-Andrade Lucio , Machado Vitor Tonini , Junior Antonio Carlos da Silva , Sun Sue Yazaki 
Published: May 2022

Abstract
Background: The aim of this work was to develop and validate a Health Information System (HIS) composed of a Web interface for the medical team of the Gestational Trophoblastic Disease (GTD) Outpatient Clinic, as well as a MolaApp Application for patients, as it portrays a interaction between two technological devices with simultaneous application to assist in treatment, reducing time, cost and improving the quality of communication between doctors and patients. Regarding gestational trophoblastic disease, it encompasses all pathological forms of placental trophoblastic tissue proliferation. It is recommended that the patient be followed up by specialists who know the dosage of the hCG curve, in order to diagnose early evolution to a Gestational Trophoblastic Neoplasm (GTN).Methods: For the development of SIS-Mola, a team was formed with a project manager, a requirements analyst, two programmers and four systems analysts. This is a cross-sectional technological assessment research and the project phases were defined by techniques used by software engineering that covered requirements analysis, programming and development of tools, as well as test and questionnaire applicability. The study was systematized through the intrinsic parameters of care at the GTD Outpatient Clinic.Results: The tests were carried out from November 2021 to February 2022, with an invitation to 28 eligible participants to proceed with usability and functionality assessments, using a questionnaire based on the System Usability Scale - SUS and an occurrence questionnaire. The responses obtained on the Likert scale indicated excellent reliability and credibility to the HIS. In addition, participants reported high intention to use and recommend digital tools to other Reference Centers in Brazil, suggesting additional improvements.Conclusion: The HIS, after the final results, proved to meet the essential activities of the Outpatient Clinic specialized in GTD, in the treatment of the disease, because it is technically adequate, practical and easy to handle the tools between its interfaces, as well as for the efficiency for the organization in the flow of the service, in the quality of the assistance provided and in the creation of a database that will allow accurate studies for continued education, professional and scientific improvement.
Exploring consensus and divergence in different societal groups' preferences for typical urbanized landscapes: Implications for rural planning
Authors: Yang Gaoyuan , Yu Zhaowu , Hu Xinlei , Kristensen Lone Søderkvist 
Published: May 2022

Abstract
Urbanization has brought dramatic landscape changes in rural areas, leading to the emergence of urbanized landscapes (ULs). Despite the extensive preference research on rural landscapes, the ULs has hardly been studied, especially from the outsider’s perspective. In this study, we chose three outsider groups of landscape professionals (PRs), governmental officials (GOs), and city residents (CRs) to explore their preferences towards five typical ULs: hardened water bank (HWB), big pavilion (BPA), big memorial arch (BMA), big ornamental lawn (BOL), and big square (BSQ). Quantitative method of questionnaire survey was used to identify how these ULs and their related landscape characters (LCs) were rated and ranked (N = 780), and qualitative method of semi-structured interview was used to explore a more comprehensive understanding about the outsiders’ view on rural constructions (N = 45). The results revealed 1) Although distinct ratings and rankings, the outsiders had general support for the constructions of ULs, with PRs being the most demanding group. 2) Despite various demographic backgrounds, there is surprisingly broad consensus in two preference themes, i.e. a livable village and a featured village, and it posed a challenge for the landscape designers to balance the relationship between them. 3) All the five ULs being surveyed were considered to be replaceable by other landscape forms, thus it could be unnecessary to decide which specific type to be moved away or kept in rural areas, but the more important is to investigate the site-based LCs. This study provides evidence to better understand public perception on rapid landscape change and rural constructions from the perspectives of different social groups, which has some implications for planners and decision-makers to incorporate the public shared values into planning process.
Spatio-temporal Gait Parameters in Older Patients: Comparaison of a Hospitalized Population of Fallers and Non-fallers
Authors: Bourgarel Emilie , Gaillard Victor , Risser Clémence , Blanc Frédéric , Vogel Thomas , Kaltenbach Georges , Meyer Maxence , Schmitt Elise 
Published: May 2022

Abstract
Background: The prevention of falls is a major public health issue. A fall can have serious consequences in frail patients, as are most patients hospitalized in acute geriatrics department. Gait disorders are predisposing factors for falls. They are accessible to rehabilitation and can be analyzed using tools that collect spatio-temporal parameters of walking, such as the GAITRite® mat. Objective: To find differences between the spatio-temporal gait parameters in patients who fall compared to patients who do not fall in a population of older patients hospitalized in acute geriatrics department. Material and methods: In this retrospective, observational, single-center study, patients over 75 years hospitalized in acute geriatrics department were included. For each patient, spatio-temporal gait parameters were collected using the GAITrite® mat. The patients were divided into two groups according to whether or not they had a history of fall. The spatio-temporal parameters were compared between the two groups and in relation to the general population. Results: 67 patients, with an average age of 85.9 ± 6 years, were included. Seventy percent of patients had cognitive impairment and 66% required technical walking assistance. The mean Charlson score was 7.00 +/- 1.87 and a large majority of patients was polymedicated with a mean of 7.04 +/- 3.25 medications at admission. The mean walking speed was 51.4 ± 19.9 cm/s in non-fallers group, and 47.3 ± 17.7 cm/s in fallers group (p = 0.539), indicating pathological walking in comparison with the general population of the same age (average 100 cm/s). No association was found between the spatio-temporal gait parameters and fall. Conclusion: In our population of hospitalized older adults, the spatio-temporal gait parameters didn’t seem to discriminate anymore a faller from a non-faller, probably linked to many confounding factors such as the pathological gait of the entire study population and their comorbidities.Clinical Trial registration: NCT05152069.
Estimation of genetic parameters and inbreeding depression in Piau breed pigs
Authors: de Oliveira Letícia Fernanda , Lopes Paulo Sávio , Dias Layla Cristien de Cássia Miranda , Silva Leandro Magno Dornelas e , Silva Hugo Teixeira , Guimarães Simone Eliza Facioni , Marques Daniele Botelho Diniz , Silva Delvan Alves da , Veroneze Renata 
Published: May 2022

Abstract
This study aimed to estimate genetic parameters, effective population size, inbreeding, and inbreeding depression for birth weight, weaning weight, and average pre-weaning daily weight gain (ADG) in Piau breed pigs. We used information from 3841 Piau pigs, and four linear models were fitted in single trait analyzes including or excluding maternal genetic effect, common litter effect, or a combination of these. The models’ adjustments were compared by likelihood ratio test, in which the model that presented the best fit for each trait was used to estimate (co)variance components. The inbreeding depression effect was evaluated using a linear model that included the fixed effects of sex, parity order, contemporary group, and inbreeding coefficient as a fixed covariate. Weight at birth and weaning showed low direct heritabilities (0.08 and 0.05, respectively), while ADG showed moderate heritability (0.20). Weight at birth showed high genetic correlations with weight at weaning (0.90) and with ADG (0.82). Weight at weaning and ADG also showed a high genetic correlation (0.99). There was an inbreeding increase over the generations and a reduction of the effective population size. In the last generation evaluated all animals were inbred, the average inbreeding coefficient was 0.07 and the effective population size was 20.8. It was observed a significant inbreeding effect on ADG, wherein an increase of 1% on the inbreeding coefficient resulted in a decrease of 0.005 grams on ADG. Thus, increase effective population size is mandatory for the inbreeding control and to reduce the loss of variability in this Piau population.
Non symmetry of the function ζ(s)/s
Authors: OUKIL Walid 
Published: May 2022

Abstract
We prove that ζ(s)/s ≠ ζ(1−s)/1−s for every ℜ(s) ∈ (0, 1/2) and ℑ(s) > 0 where ζ is the Riemann Zeta function. In the end of the paper, we give a discussion about the Riemann hypothesis.
Comorbidities and perceived health status in persons with history of cancer in the US
Authors: Obeng-Kusi Mavis , Vardy Janette , Bell Melanie , Choi Briana M. , Axon David R. 
Published: May 2022

Abstract
Purpose:
Comorbidities can further challenge prognosis and general wellbeing of cancer patients. This study aimed to assess the association between comorbidities and perceived health status (PHS) of United States persons with cancer.
Methods:
This retrospective study used 2019 Medical Expenditure Panel Survey (MEPS) data and included individuals who were alive throughout the year, aged 18 to 84 years, and had diagnosis for cancer. Using adjusted logistic regression models, we estimated the association of comorbidities (no, few[1/2], and more[3 or more] comorbidities) with PHS. Analyses accounted for the complex design of MEPS.
Results:
The dataset included 28,512 participants, 1,739 of which were eligible for the study. Of these, 11.16%(95%CI 9.64,12.59%); 41.73%(95%CI 39.21,43.96%) and 47.10%(95%CI 44.86,49.73%) reported having no, few, and more comorbidities, respectively. While breast(N = 356), prostate(N = 276) and melanoma(N = 273) were the most common cancers, hypertension(88.3%), hypercholesterolemia(49.5%) and arthritis(48%) were the most prevalent comorbidities. Adjusted logistic regression showed that, compared with those with no comorbidities, persons with few, and more comorbidities had 1.58(95%CI = 0.79,3.15) and 2.27(95%CI = 1.19,4.32) times greater odds of poor PHS. Younger or male patients, those with less formal education, low-income, pain, functional limitation or poor perception of mental health were more likely to regard their health as poor.
Conclusion:
About 88% of persons with history of cancer in US 18–84 years reported at least one comorbidity. Having more comorbidities, along with several other variables, was associated with poor PHS. Comorbidities management must be given special consideration to improve the prognosis and general wellbeing of persons with cancer.
Syngeneic mammary models of intraductal carcinoma reveal progression to invasiveness in the absence of a non-obligatory in situ stage
Authors: Bernhardt Sarah Margaret , Mitchell Elizabeth , Stamnes Stephanie , Calhoun Andrea , Klug Alex , Russell Tanya , Schedin Pepper 
Published: May 2022

Abstract
Background: The incidence of ductal carcinoma in situ (DCIS), a pre-invasive malignancy of the breast, has increased sharply in the U.S. following routine mammographic screening. Since not all DCIS progress to invasive ductal cancer (IDC), identifying prognostic markers predictive of progression may reduce potential for overtreatment. Mammary myoepithelial cells serve a barrier function in the progression of DCIS to IDC, and associations between myoepithelial cell differentiation status, inflammation, and risk of DCIS progression are reported. However, immune-competent mouse models of DCIS are limited. To address this gap, we interrogated whether orthotopic transplant models using syngeneic cell lines in immune-competent mice recapitulate early breast cancer progression from in situ to invasive disease. Methods: In immune-competent BALB/c and C57BL/6 mice, we used a non-surgical method to deliver six different mouse mammary tumor cell lines (D2.OR, D2A1, 4T1, EMT6, EO771, and Py230) directly into the main lactiferous duct. Mammary glands were dissected 11-35 days later and analyzed for lesion type (DCIS and IDC), myoepithelial cell differentiation state, and immune cell influx. Results: Intraductal injection of murine mammary cancer cell lines resulted in the formation of IDC at the earliest time-points in the absence of DCIS, which associated with immune cell infiltrate and loss of myoepithelial cell differentiation markers p63, SMA, and calponin. In contrast, intraductal delivery of human breast cancer cell lines (HCC70, MCF7) into immunocompromised mice readily formed DCIS-like lesions with intact myoepithelium. Meanwhile, murine mammary tumor cells intraductally injected into immunocompromised mice still failed to develop DCIS, and rapidly progressed to IDC. These data suggest that loss of the myoepithelial barrier function and progression to invasion is not exclusively dependent on an intact immune system. Conclusions: Six different mouse mammary tumor cells lines failed to form DCIS-like lesions after intraductal injection, and instead rapidly progressed to invasive disease, even in immunocompromised hosts. To interrogate the role of the immune system in DCIS progression, improved immune-competent murine models of DCIS are needed. Of potential significance, these isogenic intraductal models may be useful for the study of invasive breast cancers that occur in the absence of a non-obligatory DCIS stage.
“Choroidal nevus through a broader vision: Retinal imaging acquisition captured with Broad Line Fundus Imaging technology.”
Authors: Castilho Gabriel , Marback Eduardo , Novais Eduardo , Guerra Ricardo 
Published: May 2022

Abstract
Purpose: To describe the peculiarities in imaging acquisition of fourteen patients with choroidal nevus using the Broad Line Fundus Imaging (BLFI) technology.Study Design: Single-center, retrospective, cross-sectional analysis.Methods: We retrospectively reviewed the clinical records of 14 patients with choroidal nevus. We analyzed the retinal images by deconstructing them into color channels (Red, Green, and Blue) with broad line fundus imaging technology. The lesions were categorized as detectable or undetectable. Detectability was qualitatively characterized as dark or light following assessment by two experienced ophthalmologists.Results: We have found that choroidal nevus is undetectable in the blue channel (BC) (435 - 500 nm) and the green channel (GC) (500-585 nm). The only visible changes are related to the drusen, which appeared in BC and GC as light focal dots, correlated to the yellowish foci in the true-color image. On the red channel (RC) (585-640 nm), all lesions revealed the same pattern: a well-defined dark spot, with enhanced contrast, allowing the better visualization, measuring, and characterization of the nevus when compared with the other color channels, including the true-color imaging.Conclusion: BLFI application in choroidal nevus might be helpful at presentation, refining the diagnostic reliability, and monitoring, as it allows for better detection of alterations in the lesions. The peculiarities of the choroidal nevus are better assessed when using the RC due to its longer wavelength and deeper penetration in the retina and choroid.
Development and validation of a novel 12 to 23 Y-STR multiplex and its forensic casework application
Authors: Navarro-López Belén , Baeta Miriam , Granizo-Rodríguez Eva , Moreno-López Olatz , Kleinbielen Tamara , Ferragut Joana Francesca , Picornell Antònia , de Pancorbo Marian M 
Published: May 2022

Abstract
Y chromosomal short tandem repeats (Y-STRs) are used in forensic investigations as a useful complementary tool to autosomal markers. The ongoing development of new kits with an increasing number of markers makes it necessary to update populations typed in the Y-STR Haplotype Reference Database to reach at least 23 Y-STRs. A novel Y-STR multiplex panel was developed to offer a cost-efficient alternative to update Y-STR haplotypes from 12 to 23 loci. This panel includes the eleven markers, DYS448, DYS456, DYS458, DYS635, Y-GATA H4, DYS576, DYS481, DYS549, DYS533, DYS570 and DYS643, as well as DYS385a/b for traceability purpose. Developmental validation of this panel was conducted following the recommendations of the Scientific Working Group on DNA Analysis Methods (SWGDAM), showing highly sensitivity, tolerance to common inhibitors as well as high species specificity. It was efficient for degraded DNA samples and for detection of male mixtures. When applying it for extending the current data of the Ibiza population, both the discrimination capacity and the haplotype diversity increased from 0.5952 to 0.9048 and from 0.9808 to 0.9977, respectively. Together, the study demonstrates the suitability of this panel in forensic casework.
The secret life of wild animals revealed by accelerometer data: How landscape diversity and seasonality influence the behavioural types of European hares
Authors: ULLMANN WIEBKE , FISCHER CHRISTINA , KRAMER-SCHADT STEPHANIE , PIRHOFER-WALZL KARIN , ECCARD JANA A. , WEVERS PHILIPP , HARDERT ANGELIQUE , SLIWINSKI KATHARINA , CRAWFORD MICHAEL S. , GLEMNITZ MICHAEL , BLAUM NIELS 
Published: May 2022

Abstract
Context: Landscape composition and configuration, as well as seasonal landscape dynamics shape the behaviour, movement and energy expenditure in animals, i.e. foraging, hiding or fleeing, and ultimately survival. Especially in highly modified agricultural systems it is crucial to gain an understanding of how animal behaviour is influenced by landscape composition and configuration to ensure sustainable land management concepts. Objectives: We show how landscape composition and configuration and seasonal dynamics affect animal behavioural types, accounting for the different life-history events in both sexes. Methods: We investigated 34 European hares in two contrasting agricultural landscapes differing in landscape composition and configuration (simple vs. complex) by using tri-axial accelerometer data to classify the animals’ behaviour into five categories: resting, foraging, moving, grooming and standing upright (i.e. vigilance behaviour). We then tested whether the amount of behaviours per category changed with landscape composition and configuration, season and sex. Results: During peak breeding, hares in areas of high habitat diversity rested more, moved less and spent less time searching for resources. In winter, however, hares moved more and rested less in areas of high habitat diversity.Conclusions: High habitat diversity is particularly important during the breeding season, allowing animals to allocate enough energy into reproduction. In winter hares in areas of low habitat diversity may not find enough thermal and anti-predator shelter to move as much as they would need to cover their requirements. Hence, high habitat diversity guarantees species persistence in human-altered agricultural areas throughout the year.
Geomorphology, land-use, and hemeroby of foothills in Colombian Orinoquia: classification and correlation at a regional scale.
Authors: Niño Larry , Jaramillo Alexis , Villamizar Víctor , Rangel Orlando 
Published: May 2022

Abstract
In the management of ecosystem services, it is significant to relate land use with the physical characteristics of the terrain, which allows establishing the conditioning factors of human activities and planning their distribution. These analyzes are based on thematic cartography, usually generated with visual classifications of satellite images. Traditional mapping techniques involve limiting the timely availability of information by taking extended periods for interpretation and integration of multiple data sets. This article presents a methodology to overcome these difficulties, implements big data, machine learning, and cloud computing to generate timely thematic cartography and spatial analysis to support land use planning. The study area was delimited according to altitudinal levels that define braided and anastomosed river systems. Acquisition, processing, and classification of input data for modeling were performed on the Google Earth Engine platform. The spatial correlation between hemeroby and geomorphology was calculated with the odds ratio and its respective confidence interval. Maps of 27 geomorphological units, 11 types of land use, and six hemeroby levels are presented at a scale of 1: 50,000. Confusion matrices of implemented classification models were also reported, allowed evaluating global, user's, and producer's accuracy. Correlations between relict of natural areas with the structural environment and urban infrastructure with alluvial fans stand out. The information generated by these procedures is essential for planning land use and prioritizing the maintenance of ecosystem services.
Evaluating seasonal variation in trace element content of savory
Authors: Miladinović Dragoljub , Dimitrijević Marija , Mrmošanin Jelena , Marković Marija , Pavlović Aleksandra 
Published: May 2022

Abstract
Background and aimsSatureja kitaibelii Wierzb. ex Heuff. (savory) is one of the most popular herbs in Serbia, used as a culinary plant, as well as tea in traditional medicine. The objective of this study was an analysis of seasonal variation in trace element contents in the soil and S. kitaibelii, at the Kravlje village, southeastern Serbia, with emphasis on potential aspects of health promotion.MethodsWe studied the total content of B, Si, Cr, Mn, Ni, Cu and Zn in the soil and savory using inductively coupled plasma-optical emission spectrometry. The obtained results were analyzed by chemometric methods: hierarchical cluster analysis (HCA) and principal component analysis (PCA).ResultsChemical, statistical and chemometric analysis confirmed a variation in trace element content of studied soil and plant samples. The lowest contents of the studied elements in the soil, except for silicon, were recorded in the vegetative stage. In the plant, the boron content is the highest: 10.5-14.9 mg/kg and the chromium content is the lowest: 0.17-1.2 mg/kg. The highest values of soil-to-plant transfer factor were recorded for five elements (except Si and Cr) in the vegetative stage.ConclusionThe present study revealed that savory from Serbia can be considered an accumulator of boron and a potential source of valuable trace elements. A significant percentage of daily intake of B, Cr and Ni, can be provided with three cups of tea per day of plants collected in the vegetative and flowering stages.