bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Novel Hybrid Proportional Derivative/H-infinity Controller Design for Improved Trajectory Tracking of a Two-Link Robot Arm
Authors: Bankole Adesola Temitope , Igbonoba Ezekiel Endurance Chukwuemeke 
Published: October 2022

Abstract
In this work, a hybrid control strategy integrating proportional derivative and H-infinity control method is proposed for a serial two-link robotic manipulator. The aim of this research is to achieve an improved trajectory tracking performance of the robot arm. The H-infinity controller achieves high performance and robustness in the presence of disturbances and uncertainties, such as unwanted overreaction caused by the derivative control's quick response times, while the proportional derivative controller stabilizes the nonlinear manipulator system. Simulation results using matlab shows that, the proposed hybrid controller, which integrates the advantages of both proportional derivative and H-infinity controllers, has the lowest rise time for the second link, the lowest settling time for the two links, the lowest peak time for both links and the fastest decay of the error response. In addition, the hybrid control scheme also has the lowest mean square error value, with 53.3% improvement over H-infinity controller and 91.8% improvement over proportional derivative controller, indicating improved trajectory tracking performance when compared to pure proportional derivative and pure H-infinity controllers, respectively. It was also discovered that, the hybrid controller has the lowest Integral Absolute Error (IAE), Integral Square Error (ISE), Integral Time Absolute error (ITAE) and Integral Time Square (ITSE) for the second link, while the error values for the first link are fairly okay, showing the superior performance of the hybrid controller above PD and H-infinity controllers respectively.
Prospective observational study of dihydroartemisinin-piperaquine treatment of vivax malaria in North Sumatera, Indonesia
Authors: PASARIBU Ayodhia Pitaloka , SA'ID Ibrahim BIN , NASUTION Irma Sari , LIMAVADY Andrew , FAHMI Fahmi , BONNOT Guillaume , BIENVENU Anne-Lise , PICOT Stephane 
Published: October 2022

Abstract
Objectives. Plasmodium vivax malaria treated by dihydroartemisinin-piperaquine (DHA-PPQ) in Indonesia remains a challenge. Plasmodium falciparum resistance to DHA-PPQ was documented in Asia and it is suspected that this will also be a concern for P. vivaxmalaria. Thus it is needed to test the sensitivity of P. vivax on a regular basis. Parasite clearance time (PCT) and molecular markers of resistance are efficient sentinel tools for this goal.
Methods. A prospective observational study was conducted at North Labuhan Batu Regency (Sumatra). The outcome were the clinical and parasitological efficacy of the 3-day DHA-PPQ therapy corrected by PCR and the prevalence of Pvmdr1, PvK12 and PvPM4 molecular markers of chloroquine and DHA-PPQ resistance.
Results. During the 6-months study period, 100 patients were included and 6 were lost to follow-up. Ninety-four patients were included in the per-protocol analysis. The parasite clearance half-life increased over 18h in 8.5% of the cases while no clinical recurrence were observed during the Day-28 follow-up. None of the molecular marker of ACT resistance were detected among the samples tested.
Conclusions. This study highlighted the need for active surveillance of ACT efficacy against P. vivax malaria in Indonesia, using simple method such as PCT during observational studies, as it may provide a cost-effective early warning signal.
Skeletal muscle cell protein dysregulation highlights the pathogenesis mechanism of myopathy-associated p97/VCP R155H mutations.
Authors: Luzzi Anna , Wang Feng , Li Shan , Iacovino Michelina , Chou Tsui-Fen 
Published: October 2022

Abstract
Background: p97/VCP, a hexametric member of the AAA-ATPase super family, has been associated with a wide range of cellular protein pathways such as proteasomal degradation, unfolding of polyubiquitinated proteins, and autophagosome maturation. Autosomal dominant p97/VCP mutations cause a rare hereditary multisystem disorder called IBMPFD/ALS (Inclusion Body Myopathy with Paget’s Disease and Frontotemporal Dementia/Amyotrophic Lateral Sclerosis), characterized by progressive weakness and subsequent atrophy of skeletal muscles and impacting bones and brains, such as Parkinson's disease, Lewy body disease, Huntington's disease, and amyotrophic lateral ALS. Among all disease-causing mutations, Arginine 155 to Histidine (R155H/+) was reported to be the most common one, affecting over 50% of IBMPFD patients, resulting in disabling muscle weakness, which might eventually be life-threatening due to cardiac and respiratory muscle involvement.
Methods:Induced pluripotent stem cells (iPSCs) offer an unlimited resource of cells to study pathology’s underlying molecular mechanism, perform drug screening, and investigate regeneration. Using R155H/+ patients' fibroblasts, we generated IPS cells and corrected the mutation (Histidine to Arginine, H155R) to generate isogenic control cells before differentiated them into myotubes. Further proteomic analysis allowed us to identify a series of differentially expressed proteins associated with the R155H mutation.
Results: Our results showed that R155H/+ cells were associated with dysregulated expression of several proteins involved in skeletal muscle function, cytoskeleton organization, cell signaling, intracellular organelles organization and function, cell junction, and cell adhesion.
Conclusions: Our findings provide molecular evidence of dysfunctional protein expression in R155H/+ myotubes and provide new therapeutic targets for the treatment of IBMPFD/ALS.
A Matrix Completion Method for Cycle-based Traffic Volume Estimation Using Sampled Trajectory Data
Authors: Tan Chaopeng , Yao Jiarong , Tang Keshuang 
Published: October 2022

Abstract
Cycle-based volume can describe the fluctuation of traffic demand in a more sophisticated manner, which is helpful for performance evaluation and optimization of signalized intersections. Solely using sampled vehicle trajectory data for traffic volume estimation has received increasing attention recently. However, most existing methods commonly rely on historical data or site-specific vehicle arrival distributions. This study proposes a data-driven method for cycle-based volume estimation at signalized intersections. Using the sampled trajectory data, the cyclic vehicle arrival is represented as an arrival flow rate vector to discretize the continuous arrival flow. So for a TOD (time-of-day) period, an incomplete arrival rate matrix can be constructed with a rasterization standardization step to ensure equal sizes of the arrival rate vector for each cycle. The cycle-based volume estimation problem is then transformed into a matrix completion problem, and solved through the Singular Value Thresholding (SVT) algorithm. The proposed method is evaluated through an empirical case and two simulation cases. Empirical case results show that given a penetration rate of 8.4%, the proposed method can reach 5.7% for hourly volume estimation and 17.6% for cycle-based volume estimation. Even under a penetration rate of 3.4%, it shows better robustness than three existing methods, A simulation case is done to explore the sensitivity of the proposed method to the degree of saturation, the number of lanes and the penetration rate, while another simulation case demonstrates the applicability of the proposed method in large-scale network, which is also one advantage of the proposed data-driven approach.
Evaluating the System Reliability of the Bridge StructureUsing the Unit Half-Logistic Geometric Distribution
Authors: Tolba Ahlam , Taha Ahmed , El-Desouky Beih 
Published: October 2022

Abstract
Recently, reliability concept is widely used in manufacturing fields and manyother fields. In this paper, a system of five components with a bridge networkcomponent is studied. All components are assumed to be identical and havea changeable failure rate with time. Moreover, all components are assumed tohave the unit half-logistic geometric distribution. In addition, some propertiesincluding mean time to failure (MTTF), \[Alpha]-fractiles, and reliability equivalencefactor (REF) are studied. The bridge system is improved due to the reduc-tion and the duplication methods. Finally, numerical results are presented to illustrate the difference between these methods.
Evaluation of the content of metals and contamination indices generated by environmental liabilities, in Tacna, Peru
Authors: Quiroz César Julio Cáceda , choque Gisela July maraza , Mamani Milena Carpio , Quispe Gabriela de Lourdes Fora 
Published: October 2022

Abstract
Abandoned mines are environmental liabilities with a high potential for contamination of rivers, soils, and entire ecosystems, which constitutes a threat to wildlife, flora, and fauna, in addition to socio-environmental, economic, and human health risks. The objective of this study was to determine the degree of contamination of 5 abandoned mines to evaluate their potential environmental and social impact. The presence and concentration of arsenic, barium, cadmium, lead, chromium, mercury, and free cyanide by mass spectrometry, and hexavalent chromium by ion chromatography. The environmental indices of geoaccumulation, contamination factor, and contamination load were used to evaluate the level of contamination for each area. The results showed high contamination with a high content of arsenic (2,046 mg Kg− 1), cadmium (650 mg Kg− 1), lead (26,131 mg Kg− 1), free cyanide (92 mg Kg− 1), mercury (26.4 mg Kg− 1) above the established maximum limits, not detecting the presence of hexavalent chromium (0.03 mg Kg− 1). In Peru, there are many abandoned mines, so it is a latent danger of an environmental disaster. Therefore, it is essential to assess heavy metal contamination together with environmental risks, to establish efficient mitigation measures.
Association of sleep disturbance with clock genes and neurotransmitters in preschoolers with autism spectrum disorder
Authors: Zhu KaiXuan , Wang YunLei , Wang YuXiang , Wang XianNa , Bai Chen , Li XingZhu , Zhang HaoJie , Zhang Tong , Zhang Yan 
Published: October 2022

Abstract
Sleep disturbance is often reported in children with autism spectrum disorder, but the mechanisms involved remain unclear. In the current study 44 children with autism spectrum disorder and 44 with typical development were assessed via a sleep questionnaire and the Apple Watch. Neurotransmitter levels and clock gene mRNA levels were determined in all children. Children with autism spectrum disorder had a higher prevalence of sleep disturbance (p < 0.001) and had more sleep problems than children with typical development, including shorter total sleep time, lower sleep efficiency, and longer awake time (all p < 0.001). Orexin levels (p < 0.001) and clock gene mRNA levels were lower in children with autism spectrum disorder (both p < 0.05), and leptin levels were higher (p = 0.034). These results demonstrate the importance of clock genes and neurotransmitters in the pathogenesis of sleep disturbance in children with autism spectrum disorder. Trail registration number: ChiCTR2100046234, 2012/5/12.
Dielectric and thermodynamic study of Carbon dioxide(CO2) - methanol (CH3OH) mixture.
Authors: Fuentes-Azcatl Raúl , Domı́nguez Hector 
Published: October 2022

Abstract
In this paper is calculated and analyzed the dielectric behavior of carbon dioxide - methanol mixture and evaluate how the correct reproduction of the electrical properties of carbon dioxide and methanol influences the mixture of these two molecules. A comparison of two carbon dioxide models and three methanol models is made, where the CO2/ϵ model reproduces and improves the dielectric constant and for the methanol the TraPPE 2015 and MeOH-4P models improve the dielectric constant ϵ, the surface tension γ , and the liquid density ρ of the pure liquid at T=298.15 K and p=1 bar.
Mesalazine Inhibits amyloid formation and destabilizes pre-formed amyloid fibrils in the human insulin
Authors: Bardineshin Fatemeh , Bahramikia Seifollah , Khodarahmi Reza , Hadi Faranak 
Published: October 2022

Abstract
Amyloid formation due to protein aggregation is associated with several amyloid diseases (amyloidosis). The use of small organic ligands as inhibitors of protein aggregation is an attractive strategy to treatments for these diseases. In the present study, we evaluated the in vitro inhibitory and destabilizing effects of Mesalazine on human insulin protein fibrillation. To induce fibrillation, human insulin was incubated in 50 mM glycine buffer (pH 2.0) at 50°C. The effect of Mesalazine on insulin amyloid aggregation was studied using spectroscopic, imaging, and computational approaches. Based on the results, the Mesalazine in a concentration dependent manner (different ratios (1:0.1, 1:0.5, 1:1 and 1:5) of the insulin to Mesalazine) prevented the formation of amyloid fibrils and destroyed pre-formed fibrils. In addition, our molecular docking study confirmed the binding of Mesalazine to insulin through hydrogen bonds and hydrophobic interactions. Our findings suggest that Mesalazine may have therapeutic potential in the prevention of insulin amyloidosis and localized amyloidosis.
Population-based cortical mapping of callosal connections in the human brain
Authors: Xiong Yirong , Yang Liyuan , Wang Changtong , Zhao Chenxi , Luo Junhao , Wu Di , Ouyang Yiping , de Schotten Michel Thiebaut , Gong Gaolang 
Published: October 2022

Abstract
The corpus callosum (CC) is the principal white matter (WM) bundle supporting communication between the two brain hemispheres. Despite its importance, a comprehensive mapping of callosal connections is still lacking. Here, we constructed the first bidirectional population-based callosal connectional atlas between the midsagittal section of the CC and the cerebral cortex of the human brain by means of diffusion-weighted imaging tractography. The estimated connectional topographic maps within this atlas have the most fine-grained spatial resolution, demonstrate histological validity, and were reproducible in two independent samples. This new resource will revolutionize the investigation of interhemispheric communication and come with a user-friendly companion online tool (CCmapping) for easy access and visualization of the atlas.
Evaluation of Aedes aegypti sugar feeding behaviour in a semi-field system in Tanzania
Authors: Tenywa Frank Chelestino , Musa Jeremiah John , Musiba Revocatus Musyangi , Swai Johnson Kyeba , Mpelepele Ahmad Bakar , Okumu Fredros Okech , Maia Marta Ferreira 
Published: October 2022

Abstract
Background
Sugar feeding behaviour is an essential aspect for mosquito survival, fitness, reproduction, and competence. Understanding the behaviour of Aedes aegypti is a fundamental phenomenon for the development of new interventions for controlling the vectors. The objective of the current study was to investigate i) the time in an Ae. aegyptimosquito’s adult life when they are most likely to sugar feed ii) if sugar sources availability limits Ae. aegypti blood feeding with the aim of informing control strategies using attractive-targeted sugar baits (ATSBs)
Methods:
The preference of Ae. aegypti to feed on sugar or blood and the effect of sugar source availability on Ae. aegypti blood feeding was studied at different chronological and physiological ages in semi-field conditions in Bagamoyo, Tanzania. Experiments were done through a series of paired–choice assays whereupon mosquitoes were allowed to choose between a sugar meal or a blood meal in the form of a rabbit.
Results
In the first five days post emergence, Aedes aegypti mosquitoes were equally likely to opt for a sugar meal or a blood meal. However, after the first gonotrophic cycle Ae. aegypti prefer to feed on blood meal (OR=9.4; 95%CI= [6.7-13.0]; p<0.001) over a sugar meal (OR=1). Moreover, a nulliparous Ae. aegypti mosquitoes are less likely to blood feed if they have both sugar and blood sources available (OR=0.06; 95%CI [0.02-0.16] p<0.001).
Conclusion
In this study, sugar meal is observed to be a part of Ae. aegypti life particularly at the younger stage (nulliparous stage). Therefore, there is potential for the development of interventions such as attractive toxic sugar baits (ATSBs).
HFD-induced downregulation of TRPV2 mediates hepatic steatosis via p21 signaling
Authors: Wei Pengfei , Li Lixuan , Ran Chenqiu , Jin Mingyue , Zhao Huijuan , Yang Kelaier , Wang Yu , Jia Mengyang , Pan Hongyan , Li Qiang , Guo Jing 
Published: October 2022

Abstract

The global prevalence and incidence of nonalcoholic fatty liver disease (NAFLD) exhibit a growing trend. Although its underlying mechanism is still unknown, NAFLD is characterized by a significant accumulation of lipids. Here we report that high-fat diet (HFD) feeding HFD induced hepatic steatosis in mice, accompanied by a reduction in the expression and function of hepatic TRPV2. By conditional knockout TRPV2 in hepatocytes, we found that HFD-induced hepatic steatosis was exacerbated. In vitro model of NAFLD, we found TRPV2 regulated the lipid accumulation in HepG2 cells, and TRPV2 activation inhibited the expression ofp21andp16which are cellular senescence markers. Finally, we found administration of probenecid, TRPV2 agonist, impaired HFD-induced hepatic steatosis and suppressed HFD-induced elevation inp21andp16. Collectively, our findings imply that hepatic TRPV2 protects against the accumulation of lipids by modulatingp21signaling.
Effectiveness of Sublaminar Mersilene tape Augmented Pedicle Screws Fixation for Osteoporotic Vertebral Compression Fracture: Low-cost Modality
Authors: Kakadiya Ghanshyam , Chaudhary Kshitij 
Published: October 2022

Abstract
Background: Gradually kyphosis and collapse are a natural history of osteoporotic vertebral compression fractures (OVCF). The principle of OVCF is fixing instability, providing anterior support, and decompression. The osteoporotic spine has weak and rarified trabeculae in the cancellous bone and pedicles, which offers little resistance against screw pull-out. The sublaminar implant relies on the lamina for holds that is the strongest part of vertebrae. The study purpose was to assess the safety and efficacy of sublaminar mersilene tape augmented pedicle screws fixation as a novel and low-cost modality for OVCFs instrumentation fixation.
Methods: A retrospective study of 40 consecutive patients of the OVCFs. All patients were operated with open decompression, pedicle screw fixation, and sublaminar mersilene tape augmentation. Preoperative and postoperative clinical (visual analog scale [VAS], modified Oswestry disability index [M-ODI], neurologic deficit, revision surgeries, and infection) and radiological (axial collapse, fracture union, implant failure/back out,) parameters were compared to describe the utility of sublaminar mersilene tape augmented pedicle screws for OVCFs treatment.
Results: Compete neurological improvement was noted in 38 patients and two patients had Frankel Garde D neurology. The mean VAS was significantly improved from preoperative 8.98±0.60 to 2.76±0.54, final follow-up and M-ODI from 80.10±6.90 to 15.30±6.90. The mean local kyphosis angle was improved from 23.20°±5.90° preoperative to 5.30°±3.9°postoperatively and 3.30°± 2.50°loss of correction at final follow-up. There was no pseudoarthrosis and implant failure noted. No iatrogenic dural or nerve injury.
Conclusion: Sublaminar mersilene tape augmentation relies on the lamina for its hold, which is the strongest part of an osteoporotic vertebra. Sublaminar mersilene tape augmented pedicle screws fixation is a novel and low-cost modality for OVCFs. It provides significant improvement in clinical and radiological outcomes. This technique is an easy learning curve, user-friendly and safe, which makes this a viable alternative option for OVCFs fixation.
Geometric Programming Approximation to Dynamic Programming
Authors: Amuji Harrison O. , Igboanusi Chinemerem , Onukwube Obioma G. 
Published: October 2022

Abstract
In this paper, we have developed a geometric programming approximation to dynamic programming. The method has additional advantages of providing the cost involved in decision making and also eliminates the course of dimensionality which restricted the application of dynamic programming to small problems. We also obtained the optimal dual decision variables. We stated two lemmas, and through them, we proved that the optimal allocation policy is the same as the optimal primal decision variables and that the sum of cost matrix in Dynamic programming is the same as the cost coefficient in Geometric programming. We applied the method on a problem and obtained the optimal cost for decision making to be ₦97.30 and optimal decision policy to be (0.1, 0.2, 1, 3). This policy means that lecturers should combine to teach courses in year two and year three but each lecturer handles one course in year four and three courses in year five.
Inferring the fractional nature of Wu Baleanu trajectories
Authors: Conejero J. Alberto , Garibo-i-Orts Oscar , Lizama Carlos 
Published: October 2022

Abstract
We infer the parameters of fractional discrete Wu-Baleanu time series by using machine learning architectures based on recurrent neural networks. Our results shed light on how clearly one can determine that a given trajectory comes from a specific fractional discrete dynamical system by estimating the fractional exponent and the scaling factor.
The level of Kuwaiti society's commitment to Health protective behavior and its relationship to Somatic Symptoms and some variables
Authors: Haggag Abdelmotaleb Abdelkader 
Published: October 2022

Abstract
The extent of adherence to preventive health behavior varies from one individual to another, from one race to another, and from one society to another as a result of many cultural, social, psychological, demographic and environmental factors. Therefore, when study adherence to preventive health behavior, it is necessary to pay attention to the cultural context, differences between societies, and individual differences. This research aimed to know the level of Kuwaiti society's commitment to health protective behavior that includes: interpersonal support, general behavior, self- knowledge, nutrition behavior, health care and to determine the extent of prevalence of somatic symptoms among Kuwaiti society. Is there the correlation between the level of Kuwaiti society's commitment to health protective behavior and somatic symptoms? Is there an effect of some variables that include: (age, gender, nationality, education level, marital status, economic level, health status, obesity) on health protective behavior and somatic symptoms? An Internet-based cross-sectional study was conducted where the participants from different categories in Kuwaiti society were targeted using total population sampling. 700 participants from Kuwaiti society were recruited, between September4 and October 28, 2022. Participants completed two self-reported scales. The scales included the Somatic Symptom Scale–8 (SSS-8) and the Health Protective Behavior Scale (HPBS). The results reveal that there is low level of Kuwaiti society's commitment to health protective behavior. There is moderate level of Kuwaiti society's commitment to nutrition behavior, health care and interpersonal support. There is low level of the somatic symptoms among participants. The most common somatic symptoms among the participants were feeling a headache, insomnia and sleep problems and feeling tired or lacking in energy. There was a negative correlation between somatic symptoms and the total score of health protective behavior scale (HPBS) and the following dimensions: interpersonal support, general behavior, nutrition behavior, health care. The groups most committed to preventive health behavior were: high -income people, Non-obese people, participants who aged 25-40 years, Females, Separated/divorced, Non-Kuwaiti, Participants with primary, intermediate and secondary qualifications. The groups most at risk of physical symptoms were: obese people, Patients with chronic diseases, residents, females.