bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Correlation Between Quality of Life and Positive Psychological Resources in Cancer Patients: A Meta-Analysis
Authors: Zhao Xinxin , Tong Siqi , Yang Ye 
Published: June 2022

PurposeThis study aimed to assess the evidence of the association between positive psychological resources and quality of life in patients with cancer.MethodsElectronic searching was performed to retrieve articles from PubMed, Web of Science, Embase, CNKI, and CBM (from inception to 7 April 2022). Summary correlation coefficient (r) values were extracted from each study, and 95% CIs were calculated by the random-effect model. Subgroup and sensitivity analyses were performed to investigate potential heterogeneity.ResultsIn total, sixty-six articles were included in the present study. The pooled r for resilience was 0.71 (95%CI: 0.55, 0.87), hope 0.50 (95%CI: 0.43, 0.56), self-efficacy 0.53 (95%CI: 0.46, 0.61), self-esteem 0.46 (95%CI: 0.28, 0.63), and optimism 0.30 (95%CI: 0.19, 0.40). For subgroup analysis, no significant differences were found between minors and adults.ConclusionThis study indicated that resilience, hope, optimism, self-esteem, and self-efficacy were positively correlated with quality of life in patients with cancers. Therefore, intervention programs should be focused on increasing state-like positive psychological resources to improve the quality of life in patients with cancer.
A Prospectively Validated Nomogram for Predicting the Risk of PHQ-9 Score ≥15 in Patients With Erectile Dysfunction: A Multi-Center Study
Authors: Zheng Yu , Gao Ming , Hou Guangdong , Hou Niuniu , Feng Xiao , Jannini Tommaso B. , Wei Di , Zheng Wanxiang , Zhang Lei , Dun Xinlong , Zhang Geng , Wang Fuli , Meng Ping , Jannini Emmanuele A. , Yuan Jianlin 
Published: June 2022

BackgroundAlthough erectile dysfunction (ED) often occurs simultaneously with depression, not all patients with ED suffer major depression (MD), with a PHQ-9 score ≥15 indicating MD. Because the PHQ-9 questionnaire includes phrases such as “I think I am a loser” and “I want to commit suicide,” the psychological burdens of ED patients are likely to increase inevitably after using the PHQ-9, which, in turn, may affect ED therapeutic effects. Accordingly, we endeavored to develop a nomogram to predict individual risk of PHQ-9 score ≥15 in these patients.MethodsThe data of 1,142 patients with ED diagnosed in Xijing Hospital and Northwest Women and Children's Hospital from January 2017 to May 2020 were analyzed. While the Least Absolute Shrinkage and Selection Operator regression was employed to screen PHQ-9 score ≥15 related risk factors, multivariate logistic regression analysis was performed to verify these factors and construct the nomogram. The training cohort and an independent cohort that comprised 877 prospectively enrolled patients were used to demonstrate the efficacy of the nomogram.ResultsThe IIEF-5 score, PEDT score, physical pain score, frequent urination, and feeling of endless urination were found to be independent factors of PHQ-9 score ≥15 in patients with ED. The nomogram developed by these five factors showed good calibration and discrimination in internal and external validation, with a predictive accuracy of 0.757 and 0.722, respectively. The sensitivity and specificity of the nomogram in the training cohort were 0.86 and 0.52, respectively. Besides, the sensitivity and specificity of the nomogram in the validation cohort were 0.73 and 0.62, respectively. Moreover, based on the nomogram, the sample was divided into low-risk and high-risk groups.ConclusionThis study established a nomogram to predict individual risk of PHQ-9 score ≥15 in patients with ED. It is deemed that the nomogram may be employed initially to avoid those with a low risk of MD completing questionnaires unnecessarily.
Exploring Clinical Risk Factors for Breast Cancer Among American Indian Women
Authors: Nadeau Melanie , Best Lyle G. , Klug Marilyn G. , Wise Kathryn 
Published: June 2022

ObjectiveVery little is known about the breast cancer risk profile among American Indian women. Previous research shows that the proportion of American Indian/Alaska Native women with baseline characteristics (commonly known breast cancer risk factors) differs from other ethnicities. This retrospective case control study was designed to the explore the association of these factors among American Indian women with and without breast cancer.MethodsCases and controls were retrospectively selected from the medical records of American Indian women who obtained their health care from Quentin N. Burdick Memorial Health Care Facility (Indian Health Service) in Belcourt, ND. For each woman with breast cancer (n = 141), two controls were selected when possible (n = 278). Risk factors examined included woman's age, age at first live birth, age of menarche, the number of previous benign breast biopsies, the total number of first-degree relatives with breast cancer, body mass index and parity. Odds ratios and 95% confidence intervals were calculated using logistic regression.ResultsMany of the associations found among American Indian women who obtained their health care from Quentin N. Burdick Memorial Health Care Facility (Indian Health Service) in Belcourt, ND, between risk factors commonly identified in other populations and breast cancer were weakly positive. Nulliparity was the only risk factor to consistently show a positive significant association (OR = 2.87, 95% CI 1.16–0.7.12).ConclusionDisparities in breast cancer incidence, mortality and screening among Northern Plains American Indian emphasize the need to better understand the risk factors associated with breast cancer in this population. Based on the results of this study, the value of current risk prediction models in American Indian communities is uncertain and clinicians should be cautious in using these models to inform American Indian patients of their risk for breast cancer.
Factors Associated With Late Antiretroviral Therapy Initiation Among People Living With HIV in Southern Iran: A Historical Cohort Study
Authors: Afrashteh Sima , Fararouei Mohammad , Ghaem Haleh , Gheibi Zahra 
Published: June 2022

ObjectivesLate initiation of antiretroviral therapy (ART) is associated with poor outcome among people living with HIV (PLHIV) and higher risk of transmission of infection. This study was conducted to identify the determinants of late ART initiation among PLHIV in Southern Iran.MethodsA historical cohort study was conducted on 1,326 PLHIV of ≥15 years of age who were registered with the behavioral diseases counseling center (BDCC) in southern Iran from August 1997 to March 2021. Late ART initiation was defined as a CD4 cell count &lt;200 cells/mm3 or having a clinical AIDS diagnosis at the time of ART initiation. The required demographic and clinical data were collected from the patients' medical records. Multiple regression analysis was conducted to define late ART initiation associated factors.ResultsLate ART initiation was found among 81.9% of patients. Based on the results of the multivariate analysis, older age (odds ratio [OR] = 1.02, 95% CI = 1.00–1.04), being single (ORsingle/married = 1.80, 95% CI = 1.17–2.78), history of drug use (ORyes/no = 1.64, 95% CI = 1.02–2.62), year of ART initiation (OR2011−2013/2018−2021 = 3.65, 95% CI = 2.28–5.86), and possible route of transmission (ORdruginjection/sexual = 7.34, 95% CI = 1.16–46.21) were directly associated with the risk of late ART initiation.ConclusionsThe results show that the prevalence of late ART initiation was alarmingly high. For better infection control and better prognosis of infection, people at high risk need to be provided with timely services (e.g., diagnosis, treatment, training, and social support).
Case Report: Upper Thoracic Purely Extradural Spinal Meningioma With Nerve Root Attachment: A Case Report and Literature Review
Authors: Wang Zhao-Lin , Mou Jian-Hui , Sun Dong , Liu Peng 
Published: June 2022

IntroductionWe describe a case of purely extradural spinal meningioma (EDSMs) with nerve root attachment and present the clinical profiles, radiological findings, operative management, and follow-up data, along with a literature review. This case study is purely extradural spinal meningioma attached to the nerve root, and the available literature review discusses the diagnosis and treatment. Purely epidural spinal meningiomas are extremely rare, and only a few clinical reports are published on this disease. Although epidural meningioma is a benign tumor, the recurrence rate is higher when compared with ordinary meningioma.Case studyA 39-year-old male complained of chest and back pain with ring-shaped radiations to the precordial area and numbness in both the lower extremities. After a long walk, he felt disharmony in both his lower limbs. Magnetic resonance imaging showed a mass located on the left posterolateral side of the T1–T3 spinal cord and exhibited a dumbbell-type growth outward at the level of the T2–T3 intervertebral foramen. On the left side of the thoracic, a hemilaminectomy procedure was performed. The tumor was found in the ventral side of the left nerve root of T1 and was surrounded by the left nerve root of T2. To obliterate the tumor, the T2 nerve root was severed. The patient was advised to come for the follow-up on the 3rd, 6th, and 12th months postoperatively, and there were no complaints or signs of recurrence.ConclusionPurely extradural spinal meningioma with nerve root attachment is rare and has no clinical symptoms and image findings. To completely resect the lesion and avoid recurrence, the affected nerve root, epidural fat tissue, and nerve root sheath should be extensively resected and burned, coagulating the adjacent ventral posterior longitudinal ligament.
A Practical Nomogram and Risk Stratification System Predicting Cancer-Specific Survival for Hepatocellular Carcinoma Patients With Severe Liver Fibrosis
Authors: Yang Dashuai , Su Yang , Zhao Fangrui , Chen Chen , Zhao Kailiang , Xiong Xiangyun , Ding Youming 
Published: June 2022

ObjectiveHepatocellular carcinoma (HCC) is the second leading cause of cancer-related deaths worldwide. This study aims to construct a novel practical nomogram and risk stratification system to predict cancer-specific survival (CSS) in HCC patients with severe liver fibrosis.MethodsData on 1,878 HCC patients with severe liver fibrosis in the period 1975 to 2017 were extracted from the Surveillance, Epidemiology, and End Results database (SEER). Patients were block-randomized (1,316 training cohort, 562 validation cohort) by setting random seed. Univariate and multivariate COX regression analyses were employed to select variables for the nomogram. The consistency index (C-index), the area under time-dependent receiver operating characteristic curve (time-dependent AUC), and calibration curves were used to evaluate the performance of the nomogram. Decision curve analysis (DCA), the C-index, the net reclassification index (NRI), and integrated discrimination improvement (IDI) were used to compare the nomogram with the AJCC tumor staging system. We also compared the risk stratification of the nomogram with the American Joint Committee on Cancer (AJCC) staging system.ResultsSeven variables were selected to establish the nomogram. The C-index (training cohort: 0.781, 95%CI: 0.767–0.793; validation cohort: 0.793, 95%CI = 95%CI: 0.779–0.798) and the time-dependent AUCs (the training cohort: the values of 1-, 3-, and 5 years were 0.845, 0.835, and 0.842, respectively; the validation cohort: the values of 1-, 3-, and 5 years were 0.861, 0.870, and 0.876, respectively) showed satisfactory discrimination. The calibration plots also revealed that the nomogram was consistent with the actual observations. NRI (training cohort: 1-, 2-, and 3-year CSS: 0.42, 0.61, and 0.67; validation cohort: 1-, 2-, and 3-year CSS: 0.26, 0.52, and 0.72) and IDI (training cohort: 1-, 3-, and 5-year CSS:0.16, 0.20, and 0.22; validation cohort: 1-, 3-, and 5-year CSS: 0.17, 0.26, and 0.30) indicated that the established nomogram significantly outperformed the AJCC staging system (P &lt; 0.001). Moreover, DCA also showed that the nomogram was more practical and had better recognition.ConclusionA nomogram for predicting CSS for HCC patients with severe liver fibrosis was established and validated, which provided a new system of risk stratification as a practical tool for individualized treatment and management.
Clinical Study on the Application of Preserved Urethral Mucosa at the Prostatic Apex in Transurethral Plasmakinetic Resection of the Prostate
Authors: Liang Jun-Qiang , Ma Wang-Teng , Lu Bin-Wei , Dai Liang , Zhao Yu-Ming , Zhang Ji-Dong , Tian Bao , Liu Qing-Li 
Published: June 2022

ObjectiveTo explore the differences in the clinical efficacy, complications, and safety of transurethral plasmakinetic resection of the prostate (PKRP) by the conventional approach versus the approach preserving the urethral mucosa at the prostatic apex in the treatment of benign prostatic hyperplasia (BPH).MethodsA total of 90 patients with PKRP admitted to the First Hospital of Qinhuangdao from December 2018 to March 2021 were selected and divided into a control group (conventional PKRP, n = 45) and an observation group (PKRP with preserved urethral mucosa at the prostatic apex, n = 45). The clinical efficacy, safety, and sexual function of the groups were evaluated using the patients’ International Prostate Symptom Score (IPSS), quality of life (QoL), prostate volume, maximum flow rate (Qmax), post-void residual (PVR), blood loss, surgical resection efficiency, and surgical complication data.ResultsThe differences in the preoperative indicators, glandectomy quality, and glandectomy rate between the groups were not statistically significant (P &gt; 0.05). However, in the observation group, the surgery time and blood loss were significantly lower compared with the control group, and the resection efficiency was significantly higher, with statistical significance (P &lt; 0.05). In the follow-up, one month after surgery, the IPSS and QoL were lower in the observation group than in the control group, and the differences were statistically significant (P &lt; 0.05); three months after surgery, the PVR, IPSS, QoL, and Qmax scores were similar between the groups, with no statistical significance (P &gt; 0.05). In terms of surgical complications, the incidences of urinary incontinence and other complications after catheter extraction were significantly lower in the observation group than in the control group, and the differences between the groups were statistically significant (P &lt; 0.05).ConclusionCompared with conventional PKRP, PKRP with preserved urethral mucosa at the prostatic apex can lead to immediate urinary continence after catheter extraction, reduce intraoperative blood loss, and shorten the surgery time, thus improving the surgical efficiency.
Genomic Landscape of Metastatic Lymph Nodes and Primary Tumors in Non-Small-Cell Lung Cancer
Authors: Chen Bing , Li Rutao , Zhang Junling , Xu Lin , Jiang Feng 
Published: June 2022

Objective: To investigate the genetic mutation characteristics of non-small cell lung cancers (NSCLC) with and without lymph node metastasis.Methods: Primary lesions and metastatic lymph node lesions of 36 Chinese NSCLC patients were tested for somatic mutations, tumor mutation burden, phylogenetic and clonal evolutional analysis using a 1021-gene panel by next-generation sequencing (NGS) with an average sequencing depth of 671X.Results: In this study, eighteen patients with lung adenocarcinoma (LUAD) and 18 with lung squamous cell carcinoma (LUSC) were included. Different groups had distinct characteristics of gene mutations. CTNNB1 gene mutations were only present in Nome_LC LUAD patients (p &lt; 0.05). ARID1A mutation was however the only gene with significant alterations (p &lt; 0.05) in Nome_LC in LUSC. Phylogenetic trees of mutated genes were also constructed. Linear and parallel evolutions of metastatic lymph nodes were observed both in LUAD and LUSC.Conclusion: LUSC exhibited more genetic mutations than LUAD. Intriguingly, there was significant difference in gene mutations between Meta_LC and Nome_LC. CTNNB1 gene alteration was the key mutation in LUAD that seems to promote proliferation of the tumor and then determine T stage. On the other hand, proliferation of the tumor was characterized by ARID1A missense mutation in LUSC, thus influencing the T stage as well. Lymph node metastasis could display both linear and parallel evolutionary characteristics in NSCLC. Different metastatic lymph nodes might have exactly the same or different mutated genes, underlining the heterogeneous genomic characteristics of these cancer types.
Application of proficiency testing scheme at determining the tank capacity on the results of laser 3D scanning
Authors: Samoilenko Oleksandr , Zaiets Volodymyr , Adamenko Oleksandr , Akolzin Ivan , Glushko Yurii 
Published: June 2022

A three-level proficiency testing scheme is proposed in the form of the interlaboratory comparisons for the determination of the tank capacity of all possible types calculated by the laboratories’ own software. The proficiency testing scheme will be available to any accredited or non-accredited laboratory worldwide. Each laboratory chooses from the proposed computational tasks what it needs. To protect the confidentiality of the information within the framework of this scheme, all the Participants generate their individual codes, which they indicate in the file name with the results of their calculations.
The laboratories are suggested to pass successfully three levels of operation characteristics testing ranked by the increase of the set tasks:
1) calculation of the tanks’ interval capacities without introducing any corrections by their 3D models prepared by the Provider;
2) calculation of the tanks' interval capacities by introducing all necessary corrections by their 3D models prepared by the Provider;
3) calculation of the tanks’ interval capacities by scans that have not been subjected to preliminary preparation by the Provider.
To participate in the first level of the proficiency testing, it is necessary to:
— download the program of proficiency testing of the first level from the site SE «Ukrmetrteststandart» https://metrology.kiev.ua/ru/mezhlaboratornye-sravneniya;
— download files with point coordinates on the tank wall from Google disk Comparison: http://bit.ly/vgsucsm;
— calculate interval capacities of the tanks without the introduction of any corrections;
— send files with calibration tables of the tanks to the Provider’s e-mail: vgsucsm@gmail.com;
— if the submitted data is suitable for analysis, then register and pay for the service;
— receive the results of the proficiency testing via your e-mail;
— read the publication of the proficiency testing results in the journal «Measurement infrastructure» https://mi-journal-online.org.
At the first level of the proficiency testing, the payment is fulfilled only for the registration of the Participant and the execution of the documents on the completion of this level.
PEMODELAN TEROWONGAN PADA BATUAN DENGAN METODE FINITE ELEMENT
Authors: Wally Junaida , Riza Muhammad , Setiyarto Y. Djoko 
Published: June 2022

Dalam pemodelan suatu terowongan pada batuan sangat penting untuk memperhatikan kondisi geologi dari lokasi terowongan tersebut. Sebab pada batuan terdapat bidang diskontinu yang akan mempengaruhi model suatu terowongan. Dimana salah satunya berupa joint. Joint merupakan bagian lemah dari batuan. Dengan adanya joint maka displacement yang terjadi di sekitar terowongan menjadi lebih besar.
Pada studi ini analisis dilakukan menggunakan metode empirik, dari metode empirik akan diperoleh rekomendasi penggalian dan penyangga yang sesuai dengan kondisi geologi. Kemudian hasil tersebut akan diverifikasi dengan menggunakan metode finite element PHASE2 dan Plaxis 3D Tunnel. Pemodelan tanah/batuan yang digunakan untuk PHASE2 adalah Mohr Coulumb dan Hoek and Brown dengan mempertimbangkan joint maupun tidak ada joint. Pemodelan tanah/batuan untuk Plaxis 3D Tunnel adalah Mohr Coulumb. Pada Metode finite element terowongan akan ditinjau untuk kondisi unsupport dan support.
Nilai yang akan dianalisis pada metode numerik adalah besarnya deformasi yang terjadi di sekitar terowongan, tegangan yang bekerja di sekitar terowongan, bending moment dan shear force yang bekerja pada shotcrete.
ANALISIS STABILITAS LERENG PADA RUAS JALAN ABE-ARSO STA 3+700 DENGAN PERKUATAN GEOTEKSTIL
Authors: CHANDRA ALFIAN ADIE 
Published: June 2022

Ruas jalan Abe â€“ Arso merupakan jalur penghubung antara Kota Jayapura dan Kabupaten Keerom dan merupakan jalur utama perekonomian sebelum adanya jembatan youtefa bagi warga Keerom. Longsor yang terjadi pada ruas jalan Abe-Arso STA 3+700 sangat menganggu dan mengurangi aktifitas perekonomian dan dirasa perlu untuk dilakukan penelitian mengenai penyebab dan penanganan longsoran, Salah satu alternatif penanganan longsor yaitu menggunakan geotekstil, karena geotekstil bersifat permanen dan dalam pengerjaan atau pemasangannya tidak membutuhkan waktu yang begitu lama. Penelitian ini bertujuan untuk memperoleh faktor penyebab longsor yang terjadi di lokasi penelitian dan untuk memperoleh angka keamanan lereng jika penanganan longsor menggunakan geotekstil.
Berdasarkan metode keseimbangan gaya dan elemen hingga di peroleh faktor dominan penyebab dari kelongsoran yang terjadi dilapangan adalah: beban gempa dengan angka keamanan sebesar 0,1116, beban dengan muka air tanah sebesar 0,91. Hasil analisis pada lereng asli dengan perkuatan geotekstil yang dilakukan dengan perhitungan manual diperoleh angka kemanan sebesar 6,4 dan menggunakan plaxis diperoleh angka kemanan sebesar 6,9, kedua nilai tersebut > 1,3, lereng dalam kondisi stabil jika menggunakan perkuatan dengan geotekstil.

Kata kunci: Stabilitas lereng, geotekstil, faktor keamanan, plaxis
The chimerical world in Bertolt Brecht's drama "The Vision of Simona Mashar" and in Leon Feuchtwanger's novel "Simon"
Authors: Borkovska O. 
Published: June 2022

The article analyzes the creation of a "chimerical" world in Bertolt Brecht'sdrama "The Vision of Simon Mashar" and Leon Feuchtwanger's novel "Simon"."Irrational", "improbable", "fictional", "unusual" – there are characteristics thatunderlie the concept of "chimerical".
Extraordinary metamorphoses with characters who become in a dreamacquire the features of historical characters, who are promised to act this wayand not otherwise, a shift in time and space - the main characteristics of21"chimerical" prose or drama. Bertolt Brecht's play „The Vision of SimoneMashar”and Leon Feithwanger’s novel “Simon” is the story of Jeanne d’Arc, whoprompted the protagonist Simone to perform feats in the name of her nativeFrance, against the German invaders. Brecht created his play in direct contactwith Feuchtwanger, but as a result the authors published two different worksthat have different conceptual meanings, but the main idea of the both works is- the struggle of the French against the German occupiers. The motif of a book andthe motif of a dream are of great importance in two works, which help to connectthe fictional and the real chronotope. It is from the book that Simon learns thestory of Jeanne d’Arc. In the dream, Simon imitates the features of Jeanne d'Arcand fights. Like Jeanne d'Arc, Simon is executed by her compatriots. The workswere written during the Second World War, so the great importance is played byhistorical studies- the idea and prerequisites for the creation of the work. It isresearched how chimericaly is realized in epic drama and realistic psychologicalnovel, and how it is related to the "V-effect" in Brecht's dramas.