bluuebunny/crossref_metadata_2025_split huggingface dataset:
Diversity and activity of soil biota at a post‐mining site highly contaminated with Zn and Cd are enhanced by metallicolous compared to non‐metallicolousArabidopsis halleriecotypes
Authors: Klimek Beata , Stępniewska Klaudia , Seget Barbara , Pandey Vimal Chandra , Babst‐Kostecka Alicja 
Published: December 2022

AbstractHyperaccumulators' ability to take up large quantities of harmful heavy metals from contaminated soils and store them in their foliage makes them promising organisms for bioremediation. Here we demonstrate that some ecotypes of the zinc hyperaccumulatorArabidopsis halleriare more suitable for bioremediation than others, because of their distinct influence on soil biota. In a field experiment, populations originating from metal‐polluted and unpolluted soils were transplanted to a highly contaminated metalliferous site in Southern Poland. Effects of plant ecotypes on soil biota were assessed by measurements of feeding activity of soil fauna (bait‐lamina test) and catabolic activity and functional diversity of soil bacteria underneathA. halleriplants (Biolog® ECO plates). Chemical soil properties, plant morphological parameters, and zinc concentration in shoots and roots were additionally evaluated. Higher soil fauna feeding activity and higher bacterial community functional diversity were found in soils affected byA. halleriplants originating from metallicolous compared to non‐metallicolous ecotypes. Differences in community‐level physiological profiles further evidenced changes in microbial communities in response to plant ecotype. These soil characteristics were positively correlated with plant size. No differences in zinc content in shoots and roots, zinc translocation ratio, and plant morphology were observed between metallicolous and non‐metallicolous plants. Our results indicate strong associations betweenA. halleriecotype and soil microbial community properties. In particular, the improvement of soil biological properties by metallicolous accessions should be further explored to optimize hyperaccumulator‐based bioremediation technologies.
Lentil (Lens culinarisMedik) as nutrient‐rich and versatile food legume: A review
Authors: Kaale Lilian D. , Siddiq Muhammad , Hooper Sharon 
Published: December 2022

AbstractLentil is one of the most important food legumes consumed widely throughout the world. Lentils are produced in diverse agroecological regions, such as Asia, North and South America, Africa, and Oceania. During the last two decades (2001–2020), world production of lentils increased by 107%, from 3.15 to 6.54 million metric tons. Canada leads lentil producing countries (with 44% share of the global output), followed by India and Australia having 18% and 8% share, respectively. Being a rich source of protein, complex carbohydrates, dietary fiber, and folic acid, lentils are considered a healthy food nutritionally. Lentils also contain a number of bioactive phytochemicals, such as flavonoids, total phenolics, phytate, saponins, and tannins. Dehulling and splitting of lentils are the most‐commonly used basic processing methods. Additional value‐added operations include milling of whole or dehulled lentils and isolating fractions that are rich in protein and starch that can be used as ingredients in diverse food applications. Lentils are aligned well with the changing consumer trends towards meat alternatives, plant‐based diets, and healthy food options. Furthermore, due to increased environmental concerns for the production of meat, consumers are minimizing or even excluding meat consumption and opting for non‐meat foods produced in a sustainable manner. This review article provides an overview of lentil's production/trade, consumption trends, nutritional profile, value‐added processing, emerging research and development trends, and the role of lentil production in environmental sustainability.
TODAY’S MOST CRITICAL LEADERSHIP SKILL: NAVIGATING PARADOXES
Authors: Lewis Marianne W. , Smith Wendy K. 
Published: December 2022

AbstractThe authors, well‐known for their research into the concept of paradox, explain that “It is one thing to label challenges as paradoxical and another to know what to do about them. In our own research, we have explored that question in depth over the last 25 years. We bring that research together into an integrated model.” Within Figure 1, “The Language of Tensions,” they make the following observations: ‘‘Tensions include all types of situations where alternative expectations and demands are in opposition… Dilemmas present opposing alternatives, each option offering a logical solution on its own. Leadership problems and challenges often show up for us as a dilemma, where we feel pressure to choose between alternative options… Paradoxes are interdependent, persistent contradictions that lurk within our presenting dilemmas. They note that in their research, they “identify four organizational challenges associated with underlying paradoxes. We describe them as obligation (performing paradoxes), innovation (learning paradoxes), globalization (belonging paradoxes) and coordination (organizing paradoxes).” They also describe ‘‘The Paradox System. These integrated sets of tools enable both/and thinking. As memory aid, think ABCD: tools that shift how we think (assumptions) and how we feel (comfort), as we build static structures (boundaries), while enabling adaptive practices (dynamics).
Polyimide/Silica Nanocomposites with Enhanced Tensile Strength: Size Effects and Covalently Bonded Interface
Authors: Wang Yu , Yang Wenlong , Lin Jiaqi , Liu Xinmei , Zuo Yuhang , Sun Hongguo , Yang Ying 
Published: December 2022

AbstractIn this work, the tensile strength of polyimide/silica composites with the covalently bonded interface (bonded PI/SiO2) is investigated by molecular dynamic simulation. It is found that the nanofiller with smaller size can bring out a larger number of hydrogen bonds and interfacial non‐bond energy in the composites, resulting in higher tensile strength. As the immobilization of the PI chains in the vicinity of SiO2, the covalently bonded interface is found to offer a greater reinforcing effect than the unbonded interface that is confirmed by the self‐diffusion coefficient. The tensile strength of 9 wt.% bonded PI/SiO2 composites is 11.34% higher than that of the unbounded composites. The tensile strength of PI/SiO2 composites is enhanced with the increase of SiO2 concentration up to critical mass percent (Xc), beyond which it will be decreased. To quantitatively predict Xc of PI/SiO2 composites, an empirical equation based on the non‐bond energy of the composites is proposed. The empirical equation showed that the Xc of PI/SiO2 composites ranged from 8.03 to 10.36 wt.%, which is consistent with experimental values. These results provided the understanding of size‐dependent covalently bonded interface structure, which would be beneficial to the design of nanocomposites with excellent mechanical performances.
Spectrum of Pediatric to Early Adulthood POLR3A‐Associated Movement Disorders
Authors: Zea Vera Alonso , Bruce Adrienne , Larsh Travis R. , Jordan Zachary , Brüggemann Norbert , Westenberger Ana , Espay Alberto J. , Gilbert Donald L. , Wu Steve W. 
Published: December 2022

ABSTRACTBackgroundPOLR3A pathogenic variants are associated with hypomyelination, hypodontia, hypogonadism, and movement disorders.CasesWe describe the range of movement disorders seen in six patients (four female, two male) with POLR3A variants [three novel (c.2214del, c.3775G>A, c.3905G>T) and six previously reported (c.760C>T, c.1771‐7C>G, c.1909+22G>A, c.2005C>T, c.2422C>T, c.3337‐11T>C)]. Patient 1 presented with a neonatal progeroid syndrome and developed parkinsonism, dystonia, ataxia, and spasticity. Patient 2 presented with infant‐onset rapidly progressive chorea, and dystonia. Three patients (patients 3, 5, 6) presented predominantly with ataxia in combination with spasticity and dystonia. Patient 4 developed segmental dystonia during adolescence and ataxia in early adulthood. Four patients had vertical gaze impairment. The most common brain MRI abnormality was T2‐weighted/FLAIR hyperintensity of the superior cerebellar peduncles and midbrain.ConclusionPOLR3A‐related disorders exhibit significant phenotypic pleomorphism. Vertical gaze dysfunction and T2‐weighted/FLAIR hyperintensity of the superior cerebellar peduncles and midbrain may be useful signs suggestive of this condition.
Physiologically‐Based Kinetic Modeling Predicts Similar In Vivo Relative Potency of Senecionine N‐Oxide for Rat and Human at Realistic Low Exposure Levels
Authors: Widjaja Frances , Alhejji Yasser , Yangchen Jamyang , Wesseling Sebastiaan , Rietjens Ivonne M. C. M. 
Published: December 2022

ScopeThis study aims to determine if previously developed physiologically‐based kinetic (PBK) model in rat can be modified for senecionine (SEN) and its N‐oxide (SENO), and be used to investigate potential species differences between rat and human in relative potency (REP) of the N‐oxide relative to the parent pyrrolizidine alkaloid (PA).Methods and resultsIn vitro derived kinetic parameters including the apparent maximum velocities (Vmax) and Michaelis–Menten constants (Km) for SENO reduction and SEN clearance are used to define the PBK models. The rat model is validated with published animal data, and the toxicokinetic profiles of SEN from either orally‐administered SENO or SEN are simulated. REP values of SENO relative to SEN amount to 0.84 and 0.89 in rat and human, respectively.ConclusionThe REP value can be dose‐ and species‐dependent, with the values for rat and human being comparable at low realistic exposure scenarios. In summary, PBK modeling serves as a valuable New Approach Methodology (NAM) tool for predicting REP values of PA‐N‐oxides and may actually result in more accurate REP values for human risk assessment than what would be defined using in vivo animal experiments.
Harmonic‐tuned high‐efficiency GaN power amplifier with precise AM‐AM and AM‐PM characteristics
Authors: Haider Muhammad F. , Xiao Zehua , You Fei , He Songbai 
Published: December 2022

AbstractAn optimal balance between high efficiency and high linearity is one of the main performance metrics of modern base stations to handle the deep compression of the power amplifier (PA) module. In principle, the plethora of amplitude‐to‐amplitude (AM‐AM) and amplitude‐to‐phase (AM‐PM) distortions are issues worth exploring. Therefore, this paper presents a linearized harmonic‐tuned PA that operates at 2.4 GHz. The presented PA utilizes a compact input matching network (IMN) and output MN (OMN) with shunt‐connected tunable resonant circuits augmented by the stabilization network, whose presence greatly reduces the transistor parasitics and high‐order effects. Hence, a joint embodiment of each other gives optimal fundamental impedance matching alongside harmonic terminations and precise AM/PM waveform properties. The measurement results have shown that the fabricated PA exhibits peak saturated output power of 40.9 dBm and peak drain efficiency (DE) of 67%. In addition, the AM‐AM and AM‐PM curves under continuous‐wave excitation yield a gain flatness of 0.5 dB over a 37.5 dBm power range and ±3.5° phase distortion, respectively, when the input power level is swept up to the saturation level of 40 dBm. When driven with a 5 MHz 64‐QAM OFDM signal and 6.9 dB power back‐off, the manufactured PA meets the adjacent channel leakage ratio specification of −30 dBc at an average output power of 34.5 dBm.
Design of a wide beamwidth spherical conformal antenna array for ship‐borne applications
Authors: Luo Yu , Zhao Guangying , Yan Ningning , An Wenxing , Ma Kaixue , Meng Fanyi 
Published: December 2022

AbstractThis study presents the phase setting method for a spherical conformal antenna array to achieve a wide beamwidth circularly polarized radiation pattern. A dodecahedral spherical array was fabricated and measured to validate the phase setting method. The array adopts a regular dodecahedron spatial distribution structure composed of 11 dual‐polarization elements. By exciting 11 elements simultaneously with designed phase distributions, the proposed spherical array can achieve a wide beamwidth of more than 210° with circular polarization by selecting the radius of the dodecahedron. In addition, the power division network of the array is designed and processed, and the feed network is simplified by rotating the antenna element port to control the phase. Measurements agree well with the simulations. The measured results show that the proposed spherical antenna array achieves a half‐power beamwidth of more than 210° and an axial‐ratio beamwidth of larger than 240°.
Development of Myrcene‐Based Resins with Amine Ended Poly(Propylene Glycol) Side Chains Bonded Through Hydroxyurethane Linkages
Authors: Farkhondehnia Mohammad , Younes Georges R. , Maric Milan 
Published: December 2022

AbstractHybrid non‐isocyanate poly(urethanes) (HNIPUs) are designed from a precursor whose carbonate functionality is derived from epoxy‐functional statistical copolymers. Specifically, a bio‐based diene (β‐myrcene) is copolymerized via conventional free radical polymerization with glycidyl methacrylate (GMA) at different molar ratios, producing flexible copolymers with epoxy pendant groups, which are then reacted with carbon dioxide to yield the precursors with cyclic carbonate functionality. Subsequent addition of an amine‐terminated telechelic poly(propylene glycol) (PPG) forms urethane linkages in the side chains, whose concentration is tuned by varying the GMA initial molar fraction. The NIPUs are end‐capped with silanes to enable moisture curing, resulting in HNIPUs with elongations at break up to 150%, and relatively low elastic moduli varying from 32 kPa to 50 kPa as the number of urethane side linkages increases from 6 to 22. The swelling ratio of the NIPUs is also measured in tetrahydrofuran (THF). As the number of urethane side chains increases, the swelling ratio of the NIPUs decreases (710% to 620%), indicating a higher crosslinking density. All samples have gel contents higher than 50% in THF, indicating non‐crosslinked species in the hybrid samples which confirms the relatively low reported tensile moduli.
Submillimeter T1 atlas for subject‐specific abnormality detection at 7T
Authors: Piredda Gian Franco , Caneschi Samuele , Hilbert Tom , Bonanno Gabriele , Joseph Arun , Egger Karl , Peter Jessica , Klöppel Stefan , Jehli Elisabeth , Grieder Matthias , Slotboom Johannes , Seiffge David , Goeldlin Martina , Hoepner Robert , Willems Tom , Vulliemoz Serge , Seeck Margitta , Venkategowda Punith B. , Corredor Jerez Ricardo A. , Maréchal Bénédicte , Thiran Jean‐Philippe , Wiest Roland , Kober Tobias , Radojewski Piotr 
Published: December 2022

PurposeStudies at 3T have shown that T1 relaxometry enables characterization of brain tissues at the single‐subject level by comparing individual physical properties to a normative atlas. In this work, an atlas of normative T1 values at 7T is introduced with 0.6 mm isotropic resolution and its clinical potential is explored in comparison to 3T.MethodsT1 maps were acquired in two separate healthy cohorts scanned at 3T and 7T. Using transfer learning, a template‐based brain segmentation algorithm was adapted to ultra‐high field imaging data. After segmenting brain tissues, volumes were normalized into a common space, and an atlas of normative T1 values was established by modeling the T1 inter‐subject variability. A method for single‐subject comparisons restricted to white matter and subcortical structures was developed by computing Z‐scores. The comparison was applied to eight patients scanned at both field strengths for proof of concept.ResultsThe proposed method for morphometry delivered segmentation masks without statistically significant differences from those derived with the original pipeline at 3T and achieved accurate segmentation at 7T. The established normative atlas allowed characterizing tissue alterations in single‐subject comparisons at 7T, and showed greater anatomical details compared with 3T results.ConclusionA high‐resolution quantitative atlas with an adapted pipeline was introduced and validated. Several case studies on different clinical conditions showed the feasibility, potential and limitations of high‐resolution single‐subject comparisons based on quantitative MRI atlases. This method in conjunction with 7T higher resolution broadens the range of potential applications of quantitative MRI in clinical practice.
Safety and immunogenicity of mRNA COVID‐19 vaccine in inpatients with muscular dystrophy
Authors: Saito Tomoko , Saito Toshio , Hashimoto Hiroya , Ogata Katsuhisa , Kobayashi Michio , Takada Hiroto , Kuru Satoshi , Kimura Takashi , Nakamura Akinori , Matsumura Tsuyoshi 
Published: December 2022

AbstractIntroduction/AimsDue to muscular weakness and cardiopulmonary dysfunction, patients with muscular dystrophy (MD) have an increased risk of serious complications from coronavirus disease‐2019 (COVID‐19). Although vaccination is recommended, COVID‐19 vaccination safety and immunogenicity in these patients are unknown. We investigated reaction frequency, post‐vaccine antibody titers after two mRNA COVID‐19 vaccine doses, and clinical predictors of antibody response among patients with MD.MethodsWe recruited 171 inpatients with MD receiving two BNT162b2 mRNA COVID‐19 vaccine doses from seven hospitals. Blood samples were obtained from 53 inpatients before the first dose and 28 to 30 days after the second dose, and antibody titers were measured.ResultsOverall, 104 (60.8%) and 115 (67.6%) patients had side effects after the first and second doses, respectively. These were generally mild and self‐limited. Multiple logistic regression analysis showed that a bedridden state was associated with reduced side effects (odds ratio [OR] = 0.29; 95% confidence interval [CI], 0.12 to 0.71). The antibody titers of all participants changed from negative to positive after two vaccine doses. The geometric mean titer (GMT) of the inpatients was 239 (95% CI, 159.3 to 358.7). Older age (relative risk [RR] = 0.97; 95% CI, 0.95 to 0.99) and bedridden state (RR = 0.27; 95% CI, 0.14 to 0.51) were associated with a lower antibody titer. Patients with myotonic dystrophy type 1 (DM1) had a lower GMT than patients with other MDs (RR = 0.42; 95% CI, 0.21 to 0.85).DiscussionCOVID‐19 vaccination is safe and immunogenic in inpatients with MD. Patients with DM1 appear to have a poorer COVID‐19 antibody response than those with other MDs.
The state of pelvic floor muscle dynamometry: A scoping review
Authors: El‐Sayegh Batoul , Cacciari Licia P. , Primeau Francois L. , Sawan Mohamad , Dumoulin Chantal 
Published: December 2022

AbstractAimsTo discuss the advantages and limitation of the different pelvic floor muscle (PFM) dynamometers available, both in research and industry, and to present the extent of variation between them in terms of structure, functioning, psychometric properties, and assessment procedures.MethodsWe identified relevant studies from four databases (MEDLINE, Compendex, Web of Science, and Derwent Innovations Index) up to December 2020 using terms related to dynamometry and PFM. In addition, we conducted a hand search of the bibliographies of all relevant reports. Peer‐reviewed papers, conference proceedings, patents and user's manuals for commercial dynamometers were included and assessed by two independent reviewers.ResultsOne hundred and one records were included and 23 PFM dynamometers from 15 research groups were identified. From these, 20 were considered as clinical dynamometers (meant for research settings) and three as personal dynamometers (developed by the industry). Overall, significant heterogeneity was found in their structure and functioning, which limits development of normative data for PFM force in women. Further research is needed to assess the psychometric properties of PFM dynamometers and to standardize assessment procedures.ConclusionThis review points up to the heterogeneity of existing dynamometers and methods of assessing PFM function. It highlights the need to better document their design and assessment protocol methods. Additionally, this review recommends standards for new dynamometers to allow the establishment of normalized data.
An update on gender‐affirming phallus construction using the radial forearm free‐flap
Authors: Gottlieb Lawrence , Cripps Courtney 
Published: December 2022

AbstractAimsThe history of phallus construction parallels the advances made in plastic and reconstructive surgery whereby the era of microsurgery revolutionized numerous techniques. In 1993, we reported our early experience in phalloplasty. While the originally presented technique was a modification of the original design reported by Chang and Hwang, we now present further modifications of the past 30 years.MethodsThrough critical review of our technical modifications, as well as others', we present a comprehensive review of elements of the radial forearm free flap phallus construction.ResultsA radial forearm free flap is harvested and tubed to form the following components: urethra, shaft, and glans of the neophallus. When excess adipose tissue exists, the excess thickness is accommodated by increasing the proximal width of the flap. To optimize the venous drainage, the radial and ulnar superficial veins as well as the radial deep veins are included within the flap; however, venous flow is optimized through creation of an arteriovenous fistula within neo‐glans. To lengthen the native urethra, labia minora and vaginal mucosal flaps are employed at a preliminary stage during vaginectomy. New coronoplasty modifications offer esthetic refinements. Updates in scrotal reconstruction and implantation of erectile devices complete the total genitourinary reconstruction.ConclusionsPhallus construction has evolved significantly over time. While numerous techniques exist, no standard of care has been identified. Continue surgical evolution will provide modern solutions for problems most often encountered to improve overall outcomes for transgender and gender‐diverse patients pursuing masculinizing genitourinary reconstruction.
Nursing outcomes in wound care management: A mixed method study
Authors: Lommi Marzia , Raffaele Barbara , Tolentino Diaz Maria Ymelda , Montini Graziella , Puleio Cinzia , Porcelli Barbara 
Published: December 2022

AbstractAimThe aim of the study was to analyse the management of chronic wound outcomes and the experience of patients with chronic ulcers.DesignExplanatory mixed method.MethodsThis study consisted in a sequential explanatory mixed method with a quantitative and a qualitative phase. In the first phase, quantitative data were collected during a longitudinal study, in a convenience sample of 44 patients presenting at a nursing outpatients' clinic. Linear regression was conducted to evaluate the associations between variables. In phase two, 14 patients from the initial sample were interviewed, and the data were analysed using Giorgi's descriptive phenomenological method.ResultsThe participants, mostly males, in conditions of comorbidity and polypharmacotherapy, were mainly affected by venous leg ulcers. An association between the quality of life of patients (both physical and mental) and some socio‐demographic and clinical factors has been confirmed. I Variance analysis showed a significant wound improvement across all the measurement times. The themes identified through the qualitative analysis were: “Cared by self,” “Cared by Healthcare Providers” and “Quality of life”.