bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exercises to escalate lower extremity muscle strength in stroke patients: a scoping review
Authors: Mewo Vonny Yessy , Chayati Nur 
Published: December 2022

Introduction: Stroke sufferers with weakness and paralysis of the lower extremities are at risk of experiencing balance disorders. It causes the risk of falling for stroke sufferers. The effects of falls can result in physical injuries such as bruises, abrasions, lacerations, and even fractures, head injuries, and bleeding. The effects of falling cause physical injury and increase the longer treatment time, so that it adds to the burden on the patient and family to pay for patient care. This literature review aims to identify the types of interventions that can increase the strength of the muscle' lower extremity to prevent falls in stroke sufferers.Method: This study used JBI Scoping Review Method (Joanna Briggs Institute) from 2 database sources: Pubmed and Ebscohost. Publication 2015-2021. Keywords to search are stroke, fall risk, intervention, body balance, muscle strength.Results: There were 1,446 articles found, and six articles were worthy of review. The interventions used are training motor imagery (MI) using structured, progressive circuit class therapy (SPCCT), taping techniques from gluteal taping and hip abductor taping using elastic bands, rehabilitation programs wearing regent suits (RS) based on electromyography (EMG), low-intensity mobility training, perturbation-based balance training (PBT) and a combined assessment of the weight-bearing ratio and the four square step test. The combination of MI with structured, SPCCT provides a greater therapeutic effect on gait and leg muscle strength in stroke patients. Gluteal taping and hip abductor taping techniques using elastic bands improve functional performance in individuals with chronic stroke. A rehabilitation program that wears an RS and EMG were more effective than usual treatment in increasing the EMG pattern during movement and activities of daily living. A PBT can help prevent falls in everyday life after stroke, and the weight-bearing ratio and four square step tests can predict falls in stroke patients more precisely than the berg balance scale.Conclusion: In conclusion, the exercises, techniques and programs performed can increase lower extremity muscle strength, improve walking balance and reduce the risk of falls in stroke patients. These interventions require different times and tools according to the training carried out.
The effect of Epigallocatechin-3-Gallate (EGCG) combined with low dose sorafenib in apoptosis and Platelet-Derived Growth Factor Receptor (PDGFR) expression in hepatocellular carcinoma rats
Authors: Rosita Emilia , Prasetyo Sigit Adi , Riwanto Ignasius , Atmodjo Wahyuni Lukita 
Published: December 2022

Background: Sorafenib is a targeting therapy in Hepatocellular carcinoma (HCC) that targets Vascular Endothelial Growth Factor Receptors 1 (VEGFR-1), VEGFR-2, and VEGFR-3; Platelet-Derived Growth Factor Receptors β (PDGFR-β); c-Kit proto-oncogenes; FLT-3 genes; RET proto-oncogenes; and Raf-1 genes that have the same function in suppressing tumor cell proliferation, angiogenesis, and promotes tumor cell apoptosis; but its high cost makes necessary to reduce the dosage by combining with other agents. Epigallocatechin-3-Gallate (EGCG) has great potential in cancer treatment because of its anti-angiogenesis, induced apoptosis, and low cost. This study aimed to examine the effects of combination EGCG with low dose sorafenib compared to standard dose sorafenib in apoptosis and PDGFR expression in HCC rats

Methods: Twenty-five male Wistar rats were randomly assigned into 4 groups: sham, control, EGCG+low dose sorafenib, and standard-dose sorafenib. Diethylnitrosamine (DEN) injection to induce HCC was carried out to all Wistar rats except for the sham group. After HCC was developed, the EGCG+low dose sorafenib group and standard-dose sorafenib group received the administration of the drugs for two weeks. PDGFR expression and apoptotic index were assessed in the last 3 groups. Data were analyzed using SPSS version 20 for Windows.
Results: There was a non-significant difference of mean PDGFR expression level between the EGCG+low dose sorafenib group and standard-dose sorafenib group (p>0.05); however, there was a lower significant difference of both groups compared to the control group (p<0.05). There was a non-significant difference of apoptotic index between low dose sorafenib+EGCG group and standard-dose sorafenib group (p>0.05); in addition, there were a higher not significantly different of both groups compared to the control group (p>0.05).
Conclusion: Combining low dose sorafenib with EGCG has a comparable effect with standard-dose sorafenib in reducing PDGFR of HCC, but not for apoptosis.
Clinical improvement of patients with moderate-to-severe psoriasis treated with methotrexate at Dr. Soetomo General Hospital, Surabaya, Indonesia
Authors: Made Putri Hendaria  , Afif Nurul Hidayati  , Evy Ervianti  , Muhammad Yulianto Listiawan  , Damayanti  , Irmadita Citrashanty  , Sylvia Anggraeni  , Menul Ayu Umborowati  , Budi Utomo  , Cita Rosita Sigit Prakoeswa  
Published: December 2022

Background: Psoriasis is a complex, chronic disease with increasing global incidence. Studies on the effectiveness of psoriasis therapy in Indonesia are limited. This study aimed to evaluate the patient’s clinical improvement with moderate-to-severe psoriasis vulgaris using the Psoriasis Area and Severity Index with ≥75% score reduction (PASI75).
Methods: This is a retrospective study involving patients diagnosed with psoriasis vulgaris who visited the Dermatology and Venereology Outpatient Clinic in Dr. Soetomo General Hospital between January 2016 and December 2018. The electronic medical record obtained data on demographic characteristics, the number of visits, psoriasis at initial (PASI) score before and after treatment, type and dose of treatment, and comorbidities. Data were analyzed using SPSS version 23 for Windows.
Results: Overall, 54 patients with psoriasis vulgaris were included. Almost all subjects were adults (≥18 years old) and presented with severe PASI (PASI score > 10) (96.3%). The majority of the subjects (64.8%) successfully achieved PASI75. Most subjects received methotrexate (72.2%); the most frequent dosage was 15 mg/week (61.5%). A significant association was found between methotrexate treatment and a larger improvement in PASI scores (p=0.001).
Conclusion: moderate-to-severe psoriasis therapy in terms of PASI75 achieved a satisfactory success rate of 64.8%, and the improvement of PASI score was significantly better in patients who received methotrexate. Further studies in Indonesia are needed to explore the effectiveness of psoriasis therapy and its factors.
Faculty members’ readiness for interprofessional education
Authors: Eka Ni Gusti Ayu , Manik Marisa Junianti , Houghty Grace Solely , Puspitasari Vivien , Marlina Mona , Suryadinata Neneng 
Published: December 2022

Introduction: Healthcare is a complex system that requires collaboration across health professions. However, a plethora of reports has identified poor communication and collaboration within healthcare teams which could lead to patient safety issues. Interprofessional education (IPE) is an educational strategy to promote communication and collaboration between healthcare professionals. Despite knowing the readiness among students, opinions among faculty members regarding the need for IPE at UPH (Universitas Pelita Harapan) have yet to be examined despite the important roles of both students and faculties in developing an IPE curriculum. This study aimed to investigate the readiness among medical and nursing faculty members in establishing an IPE curriculum at UPH.
Methods: This study applied a quantitative study design using the Readiness for Interprofessional Learning Scale (RIPLS) by Parsell and Bligh (1999) which was translated to Indonesian and tested for its validity and reliability. The translated RIPLS questionnaire was administered to a total of 60 participants which consisted of 30 nursing and 30 medical faculty members. Subsequently, both descriptive and Mann-Whitney statistical analyses were conducted.
Results: Findings revealed a statistically significant difference between the IPE scores (RIPLS) of nursing faculties and medical faculties (U = 652, z = 3.028; p = 0.012, r = 0.390). This demonstrates that the nursing faculty members (Median 4.30) indicated a higher level of readiness or more positive attitude towards IPE compared to the medical faculty members (Median 4.07).
Conclusions: This study highlights that faculty members have a positive attitude or readiness toward IPE, with nursing faculties indicating higher levels of readiness than their counterparts in the medical faculty. Further exploration using a qualitative method is also important to understand the faculty members’ readiness for IPE as well as the commitments of faculty members and leadership on delivering IPE.
Stress associated with hypertension in middle-age and elderly in Binong, Tangerang
Authors: Pakpahan Martina , Eka Ni Gusti Ayu , Florensa Maria Veronika Ayu 
Published: December 2022

Introduction: It is widely recognized that stress cannot be eliminated from one's life and that stress may be associated with the prevalence of hypertension, for which the role of stress as a risk factor is being debated in terms of its correlation with hypertension incidence. This study examined the correlation between the stress of the middle-aged and elderly with hypertension.
Methods: This study applied a cross-sectional study using purposive sampling to recruit the respondents in Binong Tangerang, Indonesia. A modified questionnaire was used to collect the demographic data, stress, and smoking behavior. Blood pressure examinations were also conducted to identify the level of hypertension.
Results: A total of 145 respondents consisted of 79 (54.5%) middle age and 66 (45.5%) elderly were examined. Most of the respondents (82.8%) were female, and half of them were Sundanese (50.3%). Half of the respondents were categorized as pre-hypertension (42.8- 53.1%), where most of the respondents had non-smoking behavior (82%), and half of them were at the level of severe stress (57.2%). There was a significant correlation between respondents’ stress levels and hypertension (p-value < 0.05).
Conclusion: Stress is related to hypertension in middle age and elderly in the Binong community. Therefore, stress management training is needed to promote the quality of life for middle age and elderly with hypertension at Posbindu in the Binong community.
Nurse students’ satisfaction towards blended learning program
Authors: Sukadarma I Gusti Ngurah Ketut , Suastra I Wayan , Pujawan I Gusti Ngurah , Nitiasih Putu Kerti , Permana I Gede Yoga 
Published: December 2022

Purpose: The implementation of online learning during Covid-19 presents challenges especially for nursing education. Nurse students during online learning did not receive enough opportunities to learn clinical skill. Blended learning becomes an alternative in nursing education during Covid-19 pandemic because it offers both face-to-face and online learning.
Participants and methods: The participants of the current study were nurse students in nursing education university in Bali. 105 nurse students were invited to join blended learning program. After blended learning program, they were asked to fill an online questionnaire. 10 students were also invited to join interview.
Results: The results confirmed that students are satisfied with the interaction (M=3.77, SD=.783), instruction (M=4.04, SD=.794), instructor (M=3.88, SD=.685), and course management (M=4.06, SD=.657) of blended learning implementation. However, in terms of technology the students are neither satisfied nor dissatisfied (M=3.41, SD=.800) with blended learning program.
Conclusion: This study concluded that blended learning could be used as an alternative teaching and learning approach for nursing education especially in Covid-19 pandemic era.
Nursing care and the psychology effects on post-care nurses serving COVID-19 patients in Vera Cruz isolation room, Dili, Timor-Leste
Authors: Soares Domingos , Nursalam  , Carvalho Joaquim Gregorio de , Oqui Maximiano , Barros Ivonia , Silva Valente da 
Published: December 2022

Introduction: Coronavirus 2 (SARS-CoV-2) is a syndrome of acute respiration that is serious like corona acid ribonucleic detected, made separation and identification in pneumonia sick patients in Wuhan, China in December 2019 (WHO, 2020). Timor-Leste on May 1, 2020, 24 cumulative cases was confirmed, 16 cases recovered, 12 cases are still being treated, and 12 patients experienced psychological pressure from patients and health professional. This study aimed to determine the knowledge of nurses; nursing service and the psychological influence of nurses after providing care for Covid-19 patients.
Method: Qualitative research with a phenomenological approach has been used in this study, ten nurses who have worked serving Covid-19 patients participated in this study, and data was collected using interview guidelines, voice recorder, deep-interview, data analysis techniques by organizing data, grouping, categorical data, topic and answer formulation, data assessment and writing the results.
Result: The majority of nurses understand and apply Covid-19 prevention, but some are confused the cause. Have not carried out nursing care according to the standards of the International Counsel of Nursing (ICN) and the Timor-Leste Nursing Association, as (assessment, diagnosis, intervention, implementation, and nursing evaluation), reasoned: new job, no format, less manpower, no orientation from senior, emergency time. The majority experienced psychological effects after providing care to the Covid-19 patient.
Conclusion: This study concluded that nurses understand Covid-19, the nursing care implementation is not yet based on ICN and ETNA standards and after returning home the nurses experienced psychological effects.
Pregnancy care and the relationship between psychological factors and selfcare for pregnant women during the COVID-19 pandemic
Authors: Anggasari Yasi , Laili Uliyatul , Masruroh Nur 
Published: December 2022

Introduction: Research on the efforts made to prevent the transmission of COVID-19 in pregnant women with online antenatal care and the telehealth method as well as visits to obstetric polyclinics with improved service strategies have been carried out. However, the strategy of midwifery care by paying attention to the anxiety experienced by pregnant women in carrying out self-care during pregnancy during a pandemic and combined with policies from health workers has not been studied. The strategy applied in a pandemic situation must take into account the socio-demographic conditions of the community. Therefore, the purpose of this study was to explore the factors that influence maternity care and find interventions and strategies to develop prenatal care guidelines. This research has the potential to be applied to the socio-demographic conditions of the middle class.
Methods: The data used in this study were psychological and self-care data for pregnant women during the COVID-19 pandemic, involving 65 respondents at the Endang Widayat Maternity Hospital Sidoarjo from April to June 2021. This study is a mixed method study so the data collection process includes quantitative data. and qualitative data. Quantitative data were collected through questionnaires given to pregnant women, while qualitative data was conducted by conducting in-depth interviews with health workers who carried out pregnancy check-ups.
Results: This study showed that more than half (61.5%) of respondents had moderate self-efficacy and low psychological factors or anxiety. In addition, the bivariate analysis showed that age, education, occupation, parity status, and psychological factors have a significant association with self-efficacy with p-value respectively 0.01, 0.00, 0.03, 0.01, and 0.00.
Conclusion: The study was conducted to explore the factors that influence pregnancy care and that self-efficacy is related to age, education, occupation, and parity. Self-efficacy also affects the psychological factors of mothers during the Covid 19 pandemic. Pregnancy care during the Covid 19 pandemic is focused on increasing the mother's ability in daily self-care to minimize the spread of Covid 19 to pregnant women.
How face mask usage duration and type affect tear break-up time (TBUT): A survey of health professionals at Sanglah Hospital Denpasar
Authors: William Andy , Sutyawan Wayan Eka , Juliari I Gusti Ayu Made , Widiana I Gde Raka , Rahayu Ni Kompyang , Kusumadjaja I Made Agus 
Published: December 2022

Background: As society adapts to the new normal during the Corona Virus Disease 2019 (COVID-19) pandemic, face masks have become one of the health protocols required in the community, especially among health professionals. Wearing a mask regularly for an extended period may lead to dry eye symptoms, which cause discomfort and affect the quality of life. This study aimed to determine the association between the face mask usage duration and type with tear break-up time (TBUT) reduction among health professionals at Sanglah Hospital Denpasar.
Methods: This cross-sectional analytic study was conducted from December 2021 to January 2022. A simple cluster random sampling method was used to obtain 107 health professionals who wore face masks, aged 21-55 years old, and were qualified for both the inclusion and exclusion criteria. The data were collected using a questionnaire and a TBUT test. A chi-square test and multiple logistic regression analysis were performed to determine the association. The p<0.05 was significant.
Results: TBUT reduction was experienced by 30 subjects (29%) after wearing face masks, with an average of about 6±4 seconds. The duration of mask usage ≥6.5 hours per day significantly increased the risk of TBUT reduction by 2.708 times higher than the duration <6.5 hours per day (AOR 2.708; 95% CI 1.099-6.673; p=0.027). Using a non-N95 mask increased the risk of TBUT reduction by 4.545 times higher than the N95 mask (AOR 4.545, 95%CI 0.556-37.135; p=0.125).
Conclusion: There was an association between face mask usage duration and type with TBUT reduction.
Nutraceuticals of nano-betel (Piper betle L.) leaves: prevent COVID-19 and oral cavity disease
Authors: I Gusti Ayu Ari Agung  , Sri Wahjuni  , Dewa Made Wedagama  , I Wayan Weta  , Anak Agung Wiradewi Lestari  
Published: December 2022

Introduction: Betel leaf is very popular in Asia and known to have a function as traditional medicine. And is often referred to as the "Golden Heart of Nature". This is because the betel leaf has an effect such as antimicrobial, antiviral, radioprotective, antioxidant, antiseptic, bactericidal, anti-inflammatory, antiallergic, wound healing, antiplatelet, antibacterial, antifungal, and immunomodulatory activity. Nutraceutical nano-betel leaf extract contains rich in minerals, vitamins, antioxidants, phenolic compounds, and essential oils. Effectively protects the mouth from pathogens. This research aims to review the nutraceuticals of nano-betel leaf extract to prevent COVID-19 and oral cavity disease.
Methods: This systematic review study was conducted through six steps: (1) framing the questions (based on theory); (2) Run a search (on Scopus, Google Scholar, EBSCO, ProQuest, and Science Direct publishing articles from 2020 to 2022); (3) Determine the relevant research; (4) Determine the articles come from diverse backgrounds; (5) Extraction of data from individual studies; (6) Synthesis of results using the narrative method.
Results: Betel leaf contains nutrients for oral health, immunomodulators, and COVID-19, namely protein, amino acids, vitamins A, B, C, and K, as well as minerals such as Mg, K, Ca, Fe, I, P, Zn, essential oil (eugenol, hydroxylchavicol, allylpyrocatechol, quercetin, etc). Betel leaf nano extract has a significant role as antioxidants, anti-inflammatory, antimicrobial, and antivirus, which act as anti-oral cavity disease and anti-COVID-19. Betel leaf nano extract has a significant role in curing various oral cavity diseases related to COVID-19, including fungal infections, toothache, conjunctivitis, re-current HSV, oral ulcerations, xerostomia or decreased salivary flow, and gingivitis.
Conclusion: Betel leaf nano extract has a significant role in curing oral cavity disease and COVID-19. It is recommended that research into the oral disease and COVID-19 drugs combined with viable ingredients substances from betel leaf.
Early external neurolysis surgery reduces the pain and improves the functional outcomes and quality of life among traumatic brachial plexus injury patients
Authors: Farhadi Azmi , Arfianti Lydia , Suroto Heri 
Published: December 2022

Introduction: Traumatic brachial plexus injury (TBPI) is a debilitating and devastating injury that significantly impacts individuals’ quality of life. This study aimed to evaluate the functional outcomes, pain improvement and quality of life after external neurolysis surgery in TBPI patients.
Methods: A retrospective study was conducted at Dr Soetomo Hospital in Surabaya, Indonesia. Data of TBPI patients who were operated with external neurolysis surgery from 2003 to 2020 were collected. The functional outcome was measured using disabilities of the arm, shoulder, and hand (DASH) score, the pain assessment with pain visual analog score (VAS) and the quality of life with 36-item short-form (SF-36). The outcomes were also compared between those who had the surgery less or more than 6 months after the injury.
Results: A total of 493 TBPI patients were diagnosed between 2003 to 2020. Out of total, 37 patients had external neurolysis surgery, mean age of 31±12.5 years, were included in the analysis. External neurolysis surgery in TBPI patients improved all DASH, VAS and SF-36 scores and these improvements were likely influenced by sex, age, occupation, affected side and the level of the injury. In addition, our data also suggested that the patients who had external neurolysis surgery before 6 months had better outcomes than those after 6 months after the injury in term of DASH, VAS and SF-36 scores.
Conclusion: In TBPI cases, earlier external neurolysis surgery could result in better pain reduction, functional outcome and quality of life outcomes.
Association of neutrophil-lymphocyte ratio (NLR) with the anthracycline-based neoadjuvant chemotherapy (NAC) clinical response in locally advanced breast cancer (LABC) in young women
Authors: Vania Idelia Winantyo  , Vidi Vianney Chrisana Magrit Tanggo  , Iskandar Ali  
Published: December 2022

Background: Breast cancer in young women is one of the leading causes of cancer death in young women worldwide, including in Indonesia. Most patients come to the hospital at the advanced stage. Neoadjuvant chemotherapy (NAC) is the standard treatment for locally advanced breast cancer. However, half of breast cancer patients had a negative response to therapy.
Methods: A retrospective cohort, analytic observational study to determine the association between NLR and anthracycline-based NAC clinical response in locally advanced young age breast cancer in Dr. Soetomo General Hospital, Surabaya.
Results: We analyze a total of 44 patients. 81.8% had stage IIIB, 93.2% >50 mm tumor size. Most of the cases had invasive ductal carcinoma type (86.4%), grade 3 (52.3%), and Luminal B HER2-negative type (34.1%). 52.3% of patients had a negative clinical response. The mean NLR was 3.07 ± 1.69, with a cut-off value of 2.805. There was no significant association between age, tumor size, histopathological type, grade, and subtype with neoadjuvant chemotherapy clinical response. There was a significant relationship between NLR with anthracycline-based NAC clinical response in locally advanced young age breast cancer (p < 0.001).
Conclusion: There was a significant relationship between NLR with the anthracycline-based neoadjuvant chemotherapy clinical response in young women with LABC.