bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cluster dynamics of knowledge on efficiency of and demand for Russian studies in quantum technologies
Authors: Arutyunov V. V. 
Published: March 2022

The author evaluates the effectiveness of Russian research studies in quantum technologies (including use of quantum computers, quantum cryptography, quantum communications) in 2011–2020. The analysis is based on the Russian Science Citation Index and scientometric indicators: researcher publication activity – yearly number of publications of research findings, citations and penetration of these publications.The author found that almost till the end of the reviewed decade the number of publications and citation had been constantly increasing which evidenced on the increasing interest of Russian researches toward this area not prevented even by the 2014 crisis: at the end of the period, the number of publications outstripped the minimum of 2011 four times, and in 2013, it exceeded the citation maximum two times. The author points to the fact that the highest publication activity and citation of Russian researchers was in the area of quantum computers, and the lowest – in quantum communications; the highest demand was demonstrated in 2012 in quantum communications. The maximum penetration in the area of quantum computers of 2017 is approx. by half and twice lower than the similar indicator in quantum cryptography in 2011 and quantum communications.The relatively low indicators of penetration of research products in 2020 via all vectors are obviously of the same nature as the low citation indexes in 2020: the delayed response of scientific community to current year publications. The highly demanded vectors of studies in various areas of quantum technologies are determined. The illustrations are provided.
Pengembangan Perangkat Pembelajaran Matematika Bilingual Berbasis Kearifan Lokal Kalimantan Selatan
Authors: Ranti Mayang Gadih 
Published: March 2022

ABSTRAKPenelitian ini bertujuan untuk mengembangan perangkat pembelajaran matematika bilingual berbasis kearifan lokal kalimantan Selatan yang dilakukan untuk menjawab tantangan masa kini yaitu pentingnya mahasiswa memiliki kemampuan berbahasa Inggris dan pentingnya menjaga kelestarian unsur-unsur kearifan lokal agar tidak tergerus di tengah era globalisasi. Penelitian ini merupakan penelitian Research & Development (R & D) yang menghasilkan produk berupa perangkat pembelajaran matematika bilingual berbasis kearifan lokal Kalimantan Selatan yann terdiri atas Rencana Pembelajaran Semester (RPS), Lembar Kerja Mahasiswa (LKM) dan Tes Hasil Belajar (THB) untuk mata kuliah Statistika Dasar. Perangkat pembelajaran disusun dalam dua bahasa yaitu Bahasa Inggris dan Bahasa Indonesia dan dengan mengintegrasikan nilai-nilai kearifan lokal Kalimantan Selatan didalamnya. Proses pengembangan dilakukan melalui 4 tahap sesuai model pengembangan 4-D yaitu Define, Design, Develop, dan Disseminate. Hasil penelitian menunjukkan perangkat pembelajaran matematika bilingual berbasis kearifan lokal yang dihasilkan termasuk kategori valid, praktis dan efektif.Kata Kunci: perangkat pembelajaran, matematika bilingual, kearifan lokalABSTRACTThis study aims to develop mathematics bilingual learning pack based on local wisdom which was done to answer current challenges i.e the need of English skill for students and to maintain the local wisdom in order not to be eroded in globalization era. This research was a research & development (R & D) which resulted mathematics bilingual learning pack based on South Kalimantan Local Wisdom consists of Semester Lesson Plan, Worksheet and Evaluation Test on Elemantary Statistics topic.The learning pack was arranged in two languages, English and Indonesian, and integrated South local wisdom on it. The development was done by four phases, Define, Design, Develop and Disseminate. The results show that bilingual mathematics learning pack based on South Kalimantan Local Wisdom was valid, practical and effective.Keywords: Learning Pack, Bilingual Mathematics, Local Wisdom
A Highly Effective Biomass-Derived Solid Acid Catalyst for Biodiesel Synthesis Through Esterification
Authors: Zhang Songdang , Pan Hu , Huang Jinshu , Li Yuncong , Zhang Heng 
Published: March 2022

Efficient valorization of renewable liquid biomass for biodiesel production using the desirable biomass-based catalysts is being deemed to be an environmentally friendly process. Herein, a highly active biomass-based solid acid catalyst (SiO2@Cs-SO3H) with renewable chitosan as raw material through sulfonation procedure under the relatively mild condition was successfully manufactured. The SiO2@Cs-SO3H catalyst was systematically characterized, especially with a large specific surface area (21.82 m2/g) and acidity (3.47 mmol/g). The catalytic activity of SiO2@Cs-SO3H was evaluated by esterification of oleic acid (OA) and methanol for biodiesel production. The best biodiesel yield was acquired by Response Surface Methodology (RSM). The optimized reaction conditions were temperature of 92°C, time of 4.1 h, catalyst dosage of 6.8 wt%, and methanol to OA molar ratio of 31.4, respectively. In this case, the optimal experimental biodiesel yield was found to be 98.2%, which was close to that of the predicted value of 98.4%, indicating the good reliability of RSM employed in this study. Furthermore, SiO2@Cs-SO3H also exhibited good reusability in terms of five consecutive recycles with 87.0% biodiesel yield. As such, SiO2@Cs-SO3H can be considered and used as a bio-based sustainable catalyst of high-efficiency for biodiesel production.
Association Between Cholinesterase Inhibitors and New-Onset Heart Failure in Patients With Alzheimer's Disease: A Nationwide Propensity Score Matching Study
Authors: Hsieh Ming-Jer , Chen Dong-Yi , Lee Cheng-Hung , Wu Chia-Ling , Chen Ying-Jen , Huang Yu-Tung , Chang Shang-Hung 
Published: March 2022

BackgroundAutonomic nervous dysfunction is a shared clinical feature in Alzheimer's disease (AD) and heart failure (HF). Cholinesterase inhibitors (ChEIs) are widely used autonomic modulators in patients with AD, but their primary preventive benefit on new-onset HF is still uncertain.ObjectiveThis study examined whether ChEIs have a primary preventive effect on new-onset HF in patients with AD.MethodsThis propensity score matching (PSM) study was conducted using data from the National Health Insurance Research Database of Taiwan for 1995 to 2017. Certificated patients with AD and without a history of HF were divided into ChEI (donepezil, rivastigmine, or galantamine) users or nonusers. The primary endpoint was new-onset HF, and the secondary endpoints were myocardial infarction and cardiovascular death after 10-year follow-up.ResultsAfter screening 16,042 patients, 7,411 patients were enrolled, of whom 668 were ChEI users and 1,336 were nonusers after 1:2 PSM. Compared with nonusers, ChEI users exhibited a significantly lower incidence of new-onset HF (HR 0.48; 95% CI 0.34–0.68, p &lt; 0.001) and cardiovascular death (HR 0.55; 95% CI 0.37–0.82, p = 0.003) but not of myocardial infarction (HR 1.09; 95% CI 0.52–1.62, p = 0.821) after 10-year follow-up. The preventive benefit of ChEI use compared with Non-use (controls) was consistent across all exploratory subgroups without statistically significant treatment-by-subgroup interactions.ConclusionsPrescription of ChEIs may provide a preventive benefit associated with lower incidence of new-onset HF in patients with AD after 10-year follow-up.
Comparison of Perinatal Outcomes of Letrozole-Induced Ovulation and Hormone Replacement Therapy Protocols in Patients With Abnormal Ovulation Undergoing Frozen-Thawed Embryo Transfer: A Propensity Score Matching Analysis
Authors: Zhang Wenjuan , Liu Zhaozhao , Zhang Junwei , Ren Bingnan , Liu Manman , Li Jiaheng , Zhang Wen , Guan Yichun 
Published: March 2022

BackgroundWith the increasing use of frozen embryo transfer (FET), the best endometrial preparation protocol is continuously being discussed. The hormone replacement therapy (HRT) cycle and letrozole-induced ovulation (L-OI) cycle are available protocols for patients with abnormal ovulation. Previous comparisons of the two protocols have focused on pregnancy outcomes, with less attention to perinatal outcomes, and population heterogeneity was large; thus, convincing conclusions about which protocol is more appropriate could not be drawn.MethodsWe performed a retrospective cohort study using propensity score matching (PSM) analysis for a population of patients undergoing FET cycles in the reproductive center of the Third Affiliated Hospital of Zhengzhou University from January 2016 to September 2020. The main outcome measures were clinical pregnancy rate, live birth rate, very preterm delivery (VPTD), preterm delivery (PTD), low birth weight (LBW), macrosomia, small for gestational age (SGA), large for gestational age (LGA), hypertensive disorders of pregnancy (HDP), gestational diabetes mellitus (GDM), premature rupture of membranes (PROM), placenta previa, and congenital abnormality.ResultsA total of 8010 women were enrolled. Due to the large heterogeneity among the patients, we conducted 1:1 PSM, and 1461 women matched in each group. Compared with the HRT group, the L-OI group had a smaller proportion of thin endometrium (27.38% vs. 41.07%) and thicker endometrium on the day of embryo transfer (9.63 ± 1.82 vs. 8.91 ± 1.38). There were no significant differences in clinical pregnancy rate, early abortion rate or live birth rate between the groups. There was no significant difference in perinatal outcomes of singleton live birth, including VPTD, PTD, postterm delivery, LBW, macrosomia, SGA, LGA, GDM, HDP, placenta previa, and congenital malformation.ConclusionFor women with abnormal ovulation, the pregnancy and perinatal outcomes of HRT and L-OI protocols are reassuring. It seems that both protocols are safe and effective for endometrial preparation in frozen-thawed embryo transfer in the clinic.
Numerical Investigations of Liquid Film Offtake by Transverse Gas Flow in a Downcomer Annulus Geometry
Authors: Choi Chi-Jin , Cho Hyoung Kyu 
Published: March 2022

Advances in computational power have enabled the application of computational fluid dynamics (CFD) to nuclear reactor safety analyses, which require accurate predictability for two-phase flow in complex geometries. This study is aimed at validating CFD simulation of liquid film off-take in a 1/10-scale downcomer of a reactor pressure vessel under emergency core coolant (ECC) bypass conditions. Even though different flow regimes can exist simultaneously in real flow, the traditional two-phase flow models used in CFD have a disadvantage with respect to regime dependency. In this study, VOF–slip, which is a hybrid model that combines volume-of-fluid (VOF) and mixture models and is offered in STAR-CCM+ 15.04, was used to simulate the film off-take phenomenon. The key parameters in the simulation were found to be the droplet diameter and interface turbulence damping coefficient. A parametric study was performed to determine the value of the parameters that yield a reasonable liquid film thickness and ECC bypass fraction which were measured at the Seoul National University (SNU) experiment facility. For the conditions of the SNU experiment, the droplet diameter was found to be 150 μm, and the interface turbulence damping coefficient was found to be in the range of 0–30. The validation results confirmed that the VOF–slip model can describe the behavior of the liquid film and the unresolved droplet appropriately. This resulted in an improvement in predicting the ECC bypass fraction in comparison to the results using the conventional VOF model.
Multiple Dimensions of Resilience: How NEON Supports Ecology and the Research Community in the Face of Compounding Disasters
Authors: Robinson Natalie , Barnett David T. , Jones Katherine D. , Stanish Lee F. , Parker Stephanie M. 
Published: March 2022

Quantifying the resilience of ecological communities to increasingly frequent and severe environmental disturbance, such as natural disasters, requires long-term and continuous observations and a research community that is itself resilient. Investigators must have reliable access to data, a variety of resources to facilitate response to perturbation, and mechanisms for rapid and efficient return to function and/or adaptation to post-disaster conditions. There are always challenges to meeting these requirements, which may be compounded by multiple, co-occurring incidents. For example, travel restrictions resulting from the COVID-19 pandemic hindered preparations for, and responses to, environmental disasters that are the hallmarks of resilient research communities. During its initial years of data collection, a diversity of disturbances—earthquakes, wildfires, droughts, hurricanes and floods—have impacted sites at which the National Ecological Observatory Network (NEON) intends to measure organisms and environment for at least 30 years. These events strain both the natural and human communities associated with the Observatory, and additional stressors like public health crises only add to the burden. Here, we provide a case-study of how NEON has demonstrated not only internal resilience in the face of the public health crisis of COVID-19, but has also enhanced the resilience of ecological research communities associated with the network and provided crucial information for quantifying the impacts of and responses to disturbance events on natural systems—their ecological resilience. The key components discussed are: 1) NEON’s infrastructure and resources to support its core internal community, to adapt to rapidly changing situations, and to quickly resume operations following disruption, thus enabling the recovery of information flow crucial for data continuity; 2) how NEON data, tools, and materials are foundational in supporting the continuation of research programs in the face of challenges like those of COVID-19, thus enhancing the resilience of the greater ecological research community; and 3) the importance of diverse and consistent data for defining baseline and post-disaster conditions that are required to quantify the effects of natural disasters on ecosystem patterns and processes.
Integrative Analysis of the Expression Levels and Prognostic Values for NEK Family Members in Breast Cancer
Authors: Gao Wen-Liang , Niu Lei , Chen Wei-Ling , Zhang Yong-Qu , Huang Wen-He 
Published: March 2022

Background: In the latest rankings, breast cancer ranks first in incidence and fifth in mortality among female malignancies worldwide. Early diagnosis and treatment can improve the prognosis and prolong the survival of breast cancer (BC) patients. The NIMA-related kinase (NEK), a group of serine/threonine kinase, is a large and conserved gene family that includes NEK1–NEK11. The NEK plays a pivotal role in the cell cycle and microtubule formation. However, an integrative analysis of the effect and prognosis value of NEK family members on BC patients is still lacking.Methods: In this study, the expression profiles of NEK family members in BC and its subgroups were analyzed using UALCAN, GEPIA2, and Human Protein Atlas datasets. The prognostic values of NEK family members in BC were evaluated using the Kaplan–Meier plotter. Co-expression profiles and genetic alterations of NEK family members were analyzed using the cBioPortal database. The function and pathway enrichment analysis of the NEK family were performed using the WebGestalt database. The correlation analysis of the NEK family and immune cell infiltration in BC was conducted using the TIMER 2.0 database.Results: In this study, we compared and analyzed the prognosis values of the NEKs. We found that NEK9 was highly expressed in normal breast tissues than BC, and NEK2, NEK6, and NEK11 were significantly highly expressed in BC than adjacent normal tissues. Interestingly, the expression levels of NEK2, NEK6, and NEK10 were not only remarkably correlated with the tumor stage but also with the molecular subtype. Through multilevel research, we found that high expression levels of NEK1, NEK3, NEK8, NEK9, NEK10, and NEK11 suggested a better prognosis value in BC, while high expression levels of NEK2 and NEK6 suggested a poor prognosis value in BC.Conclusion: Our studies show the prognosis values of the NEKs in BC. Thus, we suggest that NEKs may be regarded as novel biomarkers for predicting potential prognosis values and potential therapeutic targets of BC patients.
Fine Mapping of the MAP2K5 Region Identified rs7175517 as a Causal Variant Related to BMI in China and the United Kingdom Populations
Authors: Lu Ce , Wang Hai-Jun , Song Jie-Yun , Wang Shuo , Li Xue-Ying , Huang Tao , Wang Hui 
Published: March 2022

Background: Genome-wide association studies (GWASs) have consistently identified MAP2K5 as an obesity susceptibility gene. To deepen our understanding of the potential causal genetic variants of this region, a fine-mapping study of MAP2K5 was conducted.Methods and Results: SNPs rs7175517 (G &gt; A) and rs4776970 (T &gt; A) were identified as the leading SNPs associated with BMI in both Chinese and the United Kingdom populations. Second, colocalization of GWAS and expression quantitative trait loci (eQTL) analyses and bioinformatic analyses indicated that rs7175517 is the functionally leading variant in the MAP2K5 gene region. Dual-luciferase assays indicated that the G allele of rs7175517 reduced the mRNA expression of MAP2K5 in HEK293T cells. The possible mechanism was that the G allele interacted with more RNA repressors from nuclei extracts, which was evidenced by electrophoretic mobility shift assays (EMSAs). Furthermore, the pathway enrichment analyses of the products from DNA pull-down and protein mass spectrometry demonstrated that the G allele of rs7175517 might interact with RNA catabolic or splicing transcription factors, which consequentially increased adiposity deposition.Conclusion: SNP rs7175517 of the MAP2K5 gene was the putative causal variant associated with BMI. More precisely designed in vitro or animal experiments are warranted to further delineate the function of MAP2K5 in adipogenesis.
Association of APEX1 and XRCC1 Gene Polymorphisms With HIV-1 Infection Susceptibility and AIDS Progression in a Northern Chinese MSM Population
Authors: Liu Bangquan , Wang Kaili , Wu Jiawei , Hu Yuanting , Yang Xun , Xu Lidan , Sun Wenjing , Jia Xueyuan , Wu Jie , Fu Songbin , Qiao Yuandong , Zhang Xuelong 
Published: March 2022

Background: Some studies have shown that the base excision repair (BER) pathway has an effect on HIV-1 replication. APEX1 and XRCC1 as key BER genes may affect DNA repair capacity. However, the roles of single nucleotide polymorphisms (SNPs) in APEX1 and XRCC1 and their impact on HIV-1 infection and AIDS progression remain unclear.Methods: A custom-designed 48-Plex SNPscan Kit was used for detection of single nucleotide polymorphisms. 601 HIV-1-infected men who have sex with men (MSM) and 624 age-matched healthy individuals were recruited in northern China. Four SNPs (rs1130409, rs1760944, rs2307486 and rs3136817) in APEX1 gene and three SNPs (rs1001581, rs25487 and rs25489) in XRCC1 gene were genotyped. The generalized multifactor dimension reduction (GMDR) method was used to identify the SNP-SNP interactions.Results: In this study, rs1130409 G allele, rs1001581 C allele and rs25487 C allele were associated with a higher risk of HIV-1 infection susceptibility (p = 0.020, p = 0.007 and p = 0.032, respectively). The frequencies of APEX1 haplotype TT and XRCC1 haplotype CT showed significant differences between cases and controls (p = 0.0372 and p = 0.0189, respectively). Interestingly, stratified analysis showed that the frequency of rs1001581 C allele was significantly higher in AIDS patients with the CD4+ T-lymphocyte count &lt;200 cells/μl than those with &gt;200 cells/μl (p = 0.022). Moreover, significant gene-gene interactions among rs1130409, rs1001581 and rs25487 were identified by GMDR (p = 0.0107). Specially, individuals with five to six risk alleles have a higher susceptibility to HIV-1 infection than those with zero to two risk alleles (p &lt; 0.001).Conclusion:APEX1 and XRCC1 gene polymorphisms were associated with the susceptibility to HIV-1 infection and AIDS progression in MSM populations in northern China.
EGFR Mutation and 11q13 Amplification Are Potential Predictive Biomarkers for Immunotherapy in Head and Neck Squamous Cell Carcinoma
Authors: Dou Shengjin , Zhang Lin , Wang Chong , Yao Yanli , Jiang Wen , Ye Lulu , Li Jiang , Wu Sicheng , Sun Debin , Gong Xiaoli , Li Rongrong , Zhu Guopei 
Published: March 2022

BackgroundHead and neck squamous cell carcinoma (HNSCC) is one of the most common malignant cancers. The treatment of HNSCC remains challenging despite recent progress in targeted therapies and immunotherapy. Research on predictive biomarkers in clinical settings is urgently needed.MethodsNext-generation sequencing analysis was performed on tumor samples from 121 patients with recurrent or metastatic HNSCC underwent sequencing analysis. Clinicopathological information was collected, and the clinical outcomes were assessed. Progression-free survival (PFS) was estimated using the Kaplan-Meier method and cox regression model was used to conduct multivariate analysis. Fisher’s exact tests were used to calculate clinical benefit. A p value of less than 0.05 was designated as significant (p &lt; 0.05).ResultsChromosome 11q13 amplification (CCND1, FGF3, FGF4, and FGF19) and EGFR mutations were significantly associated with decreased PFS and no clinical benefits after treatment with a programmed death 1 (PD-1) inhibitor. The same results were found in the combined positive score (CPS) ≥ 1 subgroup. In patients who were treated with an EGFR antibody instead of a PD-1 inhibitor, a significant difference in PFS and clinical benefits was only observed between patients with CPS ≥ 1 and CPS &lt; 1.ConclusionChromosome 11q13 amplification and EGFR mutations were negatively correlated with anti-PD-1 therapy. These markers may serve as potential predictive biomarkers to identify patients for whom immunotherapy may be unsuitable.
Epigenetic Signatures Discriminate Patients With Primary Sclerosing Cholangitis and Ulcerative Colitis From Patients With Ulcerative Colitis
Authors: de Krijger Manon , Hageman Ishtu L. , Li Yim Andrew Y. F. , Verhoeff Jan , Garcia Vallejo Juan J. , van Hamersveld Patricia H. P. , Levin Evgeni , Hakvoort Theodorus B. M. , Wildenberg Manon E. , Henneman Peter , Ponsioen Cyriel Y. , de Jonge Wouter J. 
Published: March 2022

BackgroundPrimary sclerosing cholangitis (PSC) is a chronic inflammatory liver disease affecting the intra- and extrahepatic bile ducts, and is strongly associated with ulcerative colitis (UC). In this study, we explored the peripheral blood DNA methylome and its immune cell composition in patients with PSC-UC, UC, and healthy controls (HC) with the aim to develop a predictive assay in distinguishing patients with PSC-UC from those with UC alone.MethodsThe peripheral blood DNA methylome of male patients with PSC and concomitant UC, UC and HCs was profiled using the Illumina HumanMethylation Infinium EPIC BeadChip (850K) array. Differentially methylated CpG position (DMP) and region (DMR) analyses were performed alongside gradient boosting classification analyses to discern PSC-UC from UC patients. As observed differences in the DNA methylome could be the result of differences in cellular populations, we additionally employed mass cytometry (CyTOF) to characterize the immune cell compositions.ResultsGenome wide methylation analysis did not reveal large differences between PSC-UC and UC patients nor HCs. Nonetheless, using gradient boosting we were capable of discerning PSC-UC from UC with an area under the receiver operator curve (AUROC) of 0.80. Four CpG sites annotated to the NINJ2 gene were found to strongly contribute to the predictive performance. While CyTOF analyses corroborated the largely similar blood cell composition among patients with PSC-UC, UC and HC, a higher abundance of myeloid cells was observed in UC compared to PSC-UC patients.ConclusionDNA methylation enables discerning PSC-UC from UC patients, with a potential for biomarker development.