bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tissue distribution and integrated pharmacokinetic properties of major effective constituents of oral Gegen-Qinlian decoction in mice
Authors: Lu Jing-Ze , Hong Dan-Dan , Ye Dan , Mu Sheng , Shi Rong , Song Yu , Feng Chu , Ma Bing-Liang 
Published: October 2022

Gegen-Qinlian decoction (GQD) is a classic traditional Chinese medicine (TCM) formula. GQD is effective against colon or liver-related diseases including ulcerative colitis, non-alcoholic fatty liver, and type 2 diabetes. In this study, a liquid chromatography-tandem mass spectrometry method was developed, validated, and then applied to reveal the tissue distribution and integrated pharmacokinetic properties of major effective constituents of oral GQD in mice. The established method was quick, sensitive, and accurate enough to analyze GQD constituents in plasma and tissue homogenate samples quantitatively. According to their concentrations in the portal vein, systemic circulation, liver and colon samples of the mice after oral administration of GQD, the concentration-time curves of the constituents were respectively plotted. The results showed that daidzein, baicalin, and baicalein had relatively high exposure levels in the livers, while puerarin, berberine, epiberberine, coptisine, palmatine, jatrorrhizine, magnoflorine, glycyrrhizic acid, and glycyrrhetinic acid were enriched in the colons. Given that these constituents have significant biological activity, they could be regarded as the major effective constituents of GQD in treating colon or liver-related diseases, respectively. In addition, the integrated pharmacokinetic properties of GQD were studied. The GQD “integrated constituent” reached peak concentration at 4.0 h in the portal vein, the systemic circulation, the livers, and the colons, with half-lives of 1.5–4.1 h and mean retention time of 4.5–6.3 h, respectively. Furthermore, the concentration of the GQD “integrated constituent” in the colons was approximately 10 times higher than that in the livers, both of which were much higher than that in the systemic circulation, indicating its accumulation in these tissues, especially in the colons. In conclusion, the tissue distribution and integrated pharmacokinetic properties of oral GQD were revealed in the study. The results of the tissue distribution study would contribute to identifying the major target tissues and effective constituents of GQD, while the results of the integrated pharmacokinetic study would help to explain the pharmacokinetic properties of oral GQD as a whole.
Validity evaluation of teacher’s core literacy questionnaire of public physical education
Authors: Zeng Xiaojin , Da Yi , Luo Lin 
Published: October 2022

ObjectiveThe purpose of this study was to develop a core literacy questionnaire for public physical education teachers in colleges and universities (TCLQ-PPE) to address the current lack of core literacy assessment tools for public physical education teachers in Chinese colleges and universities. The study measured the validity of the TCLQ-PPE questionnaire by collecting evidence of the validity of this questionnaire.MethodsAn initial pool of items was obtained from existing research tools, literature, and expert opinion. An expert review panel evaluated its content. A subsequent validation process reduced the number of items in the item pool. A validated factor analysis of the TCLQ-PPE was performed using structural equation modeling.ResultsThe TCLQ-PPE consists of five dimensions (professional beliefs, professional knowledge and skills, sports skills, work and life adaptation and reflection, and work management), consisting of a total of 40 items. The factorial validity of the TCLQ-PPE was determined by the significant loadings of all items on their expected factors, showing good data model fit and good stability between two independent samples. The Cronbach’s ɑ coefficient for each dimension was greater than 0.9.ConclusionThe TCLQ-PPE had sufficient evidence of validity. The development of the instrument showed evidence of validity for the content, response process, and internal structure.
COVID-19 vaccine acceptance and hesitancy in patients with Parkinson's disease
Authors: Zhou Yifan , Lin Zhengyu , Wan Xiaonan , Liu Jun , Ding Jianqing , Zhang ChenCheng , Ren Kang , Li Dianyou , Wu Yiwen 
Published: October 2022

BackgroundAs coronavirus disease 2019 (COVID-19) vaccination campaign underway, little is known about the vaccination coverage and the underlying barriers of the vaccination campaign in patients with Parkinson's disease (PD).ObjectiveTo investigate the vaccination status and reasons for COVID-19 vaccine acceptance and hesitancy among PD patients.MethodsIn concordance with the CHERRIES guideline, a web-based, single-center survey was promoted to patients with PD via an online platform from April 2022 and May 2022. Logistic regression models were used to identify factors related to COVID-19 vaccine hesitancy.ResultsA total of 187 PD cases participated in this online survey (response rate of 23%). COVID-19 vaccination rate was 54.0%. Most participants had a fear of COVID-19 (77.5%) and trusted the efficacy (82.9%) and safety (66.8%) of COVID-19 vaccine. Trust in government (70.3%) and concerns about the impact of vaccine on their disease (67.4%) were the most common reasons for COVID-19 vaccine acceptance and hesitancy, respectively. COVID-19 vaccine hesitancy was independently associated with the history of flu vaccination (OR: 0.09, p &lt; 0.05), trust in vaccine efficacy (OR: 0.15, p &lt; 0.01), male gender (OR: 0.47, p &lt; 0.05), disease duration of PD (OR: 1.08, p &lt; 0.05), and geographic factor (living in Shanghai or not) (OR: 2.87, p &lt; 0.01).ConclusionsThe COVID-19 vaccination rate remained low in PD patients, however, most individuals understood benefits of vaccination. COVID-19 vaccine hesitancy was affected by multiple factors such as geographic factor, history of flu vaccination, disease duration and trust in efficacy of vaccine. These findings could help government and public health authorities to overcome the barrier to COVID-19 vaccination and improve vaccine roll-out in PD patients.
Magnetohydrodynamics evolution of three-dimensional magnetic null in NOAA active region 11515 initiated using non-force-free field extrapolation
Authors: Kumar Sanjay , Prasad Avijeet , Sarkar Ranadeep , Bhattacharyya Ramit 
Published: October 2022

Magnetohydrodynamics simulation of active region NOAA 11515 is performed to examine the initiation of the M5.6 flaring event that starts around 10:43 UT on 2 July 2012. The simulation is conducted using an extrapolated non-force-free magnetic field generated from the photospheric vector magnetogram of the active region as the initial magnetic field. The magnetic field shows the presence of a three-dimensional (3D) magnetic null with the corresponding dome overlying a filament and a low-lying magnetic flux rope, observed in 304 Å and 131 Å respectively. The simulated dynamics, triggered by the initial Lorentz force, lead to the bifurcations of the flux rope, which is similar to the observed bifurcation in the 131 Å brightenings. Additionally, the rope exhibits a rise and reconnects at the 3D null. These reconnections convert field lines of the rope into the anchored outer spine of the 3D null—explaining the occurrence of a nearby confined C-class flare. Further, the results show that the field lines of the flux rope reach the vicinity of the filament and become non-parallel to the field lines of the filament. This initiates the reconnections between the rope and the field lines of the filament—activating the filament for the eruption. This interesting interaction of the flux rope and filament seems to contribute to the onset of the M-class flare.
Only transesophageal echocardiography guided patent foramen ovale closure: A single-center experience
Authors: Wang Su , Zhu Ge , Liu Zhang , Zhou Jian , Zang Wangfu 
Published: October 2022

BackgroundAn increasing number of studies have proved that patent foramen ovale (PFO) occlusion could reduce the incidence of recurrent stroke more than drug therapy alone under certain conditions. Which is the “best” guidance technique still remains to be discussed.MethodsA single center retrospective study enrolled 120 patients (mean age 52.51 ± 14.29 years) who underwent PFO closure between April 2019 and March 2021. 87 patients (72.5%) had suffered cryptogenic stroke (CS) at least one time, and 24 patients (20%) had repetitive episodes of hemicrania unsourced. 65 patients were in the transesophageal echocardiography (TEE) guidance group (T-group), and the other 55 patients were in the angiographic guidance group (A-group).ResultsThere were no significant differences in crucial clinical characteristics between the two groups. In T-group, the procedural success rate was higher (100% vs. 92.7%, P = 0.028), and the procedural time was shorter (23.15 ± 13.87 vs. 25.75 ± 7.19, P = 0.001). No difference was detected in the procedural complication rate. Follow-up were performed at least 12 months. At 12 months, new atrial fibrillation occurred in 1 patient (1.5%) in the T-group and in 1 patient (1.8%) in the A-group (P = 0.905). Residual shunt occurred in 1 patient (1.5%) in the T-group and in 3 patients (5.5%) in the A-group (P = 0.236). Recurrent cerebral ischemia occurred in 2 patient (3.1%) in the T-group and in 2 patients (3.6%) in the A-group (P = 0.865).ConclusionThe use of only intra-procedural TEE guidance for PFO closure is safe and effective. The whole procedure can be performed without fluoroscopy and contrast medium. The short and medium follow-up results are satisfactory, especially in the residual shunt.
IMPLEMENTASI METODE SIX SIGMA DALAM PENETAPAN STRATEGI PENINGKATAN KUALITAS JASA PERBAIKAN TURBIN
Authors: Azmi Anwar Sidik  , Sri Wahyuning Caecilia 
Published: October 2022

Companies that are involved in turbine repair service and maintenance often suffered from delayed work, which affected customer satisfaction and trust. Six-Sigma method is used to solve the delay issue. According to the research result, it is found that the capability of servicing process of a turbine in this company is 1.346s with DPMO of 560810.8. This condition is categorised as low, below the industry average in Indonesia of 2s with DPMO of 308.538. The main cause of the delay is with the unreliable work-hour prediciton, unreliability and unavailability of materials from suppliers, failure of the machines, and flawed scheduling. It is suggested to improve the service by work measurment to help predict the needs for repair schedule, rectifying the supply and maintenance system, as well as scheduling system according to the demands of repair service, repair time prediction, and the repair schedule of the machine itself
PENGELOMPOKAN PENYANDANG MASALAH KESEJAHTERAAN SOSIAL DI JAWA BARAT MENGGUNAKAN K-MEANS DAN FUZZY C-MEANS
Authors: Rohmaniah Lina , Faqih Ahmad , Suprapti Tati 
Published: October 2022

Social welfare problems still occur in some provinces in Indonesia, including in West Java. Social welfare problems cannot be completely overcome, but according to policy perceptions, they can be reduced, therefore analyses are required. Grouping data on people with social welfare problems to find out the best group based on the data will provide alternative policies and appropriate methods. The purpose of this study was to find the best group of people with social welfare problems using the k-means and fuzzy c-means methods based on the results of the DBI evaluation. The methods used for this grouping were the k-means and fuzzy c-means algorithm methods. From the results of this study, it was obtained the best 2 groups from the experiment of fuzzy c-means algorithms based on the smallest DBI assessment or close to 0 between the k-means and fuzzy c-means algorithms from each DBI value, they were k-means algorithm with value of 0.029 and fuzzy c-means algorithm with value of 0.006.
PENERAPAN ALGORITMA K-MEANS UNTUK MENGELOMPOKKAN DATA PENGIRIMAN PAKET DI KANTOR POS CIREBON
Authors: Febrian Aby , Nana Suarna  , Gifthera Dwilestari  
Published: October 2022

Pada era industri sekarang ini perkembangan ekspedisi jasa kirim mengalami peningkatan yang relatif pesat, membuat jalur perdagangan barang maupun bidang jasa menjadi meningkat untuk memenuhi kebutuhan konsumen. Salah satu ekspedisi jasa kirim yaitu PT Pos Indonesia yang merupakan Badan Usaha Milik Negara (BUMN). Kantor Pos Cirebon saat ini mempunyai banyak pesaing diantaranya yaitu JNE,TIKI, Sicepat, dan J&T. Salah satu faktor utama dalam proses pengiriman yaitu dibutuhkan keakuratan dalam mengelompokkan data pengiriman, maka diperlukan proses perhitungan yang tepat, agar dapat mencapai hasil yang akurat. Pada penelitian ini dilakukan proses clustering dengan algoritma K-Means dengan tujuan untuk mendapatkan informasi dari data pengiriman paket yang ada di Kantor Pos Cirebon pada bulan juli 2020 serta memperoleh kelompok terbaik berdasarkan hasil evaluasi DBI. Hasil cluster data pengiriman paket menggunakan algoritma K-means serta dengan perhitungan Davies Bouldin Index nilai yang paling mendekati angka 0 dengan percobaan cluster 2 sampai cluster 10 menghasilkan nilai k terbaik pada cluster 3 yaitu 0.104 dengan jumlah anggota Cluster 0: 414 items, Cluster 1: 280 items, Cluster 2: 6 items.
All InN/InGaN solid-state potentiometric chloride sensor with super Nernstian sensitivity
Authors: Xie Lingyun , Wang Peng , Yin Hongjie , Zhou Guofu , Nötzel Richard 
Published: October 2022

Abstract
We demonstrate an all-solid-state potentiometric sensor constructed from solid-state InN/InGaN sensing- and reference electrodes with the epitaxial InN/InGaN layers directly grown on Si substrates. The sensor, evaluated in KCl aqueous solution, exhibits super-Nernstian sensitivity of −78 mV/decade with good linearity for concentrations of 0.01–1 M, which is the physiologically relevant range. Good stability and re-usability are demonstrated by a long-time drift below 0.2 mV h−1 and standard deviation of 8 mV for repeated measurements over 10 d. These properties fulfil the requirements for compact, robust and highly sensitive all-solid-state sensors and sensor arrays.
ANALISIS USAHA PEMANFAATAN LIMBAH KULIT KAYU GERGAJIAN DI UD. SUMARNI KECAMATAN SUKAMAJU KABUPATEN LUWU UTARA
Authors: Nuryanti Dewi Marwati 
Published: October 2022

Utilization of waste lumber skin in addition to increasing revenue can also make efficient use of natural wood and wood folk and reduce environmental damage. Waste processing of lumber skin held in UD. Sumarni starting from procurement of raw materials, sawing, drying, sorting, packaging and marketing. Waste lumber skin used as raw materials generally durian (Durio zibethinus) wood and some kind of small porous timber such as teak (Tectona grandis L.F), Uru (Elmerrillia sp), Jabon (Anthocephalus sp) with a minimum length of 1 (one) meter, a minimum thickness of 1.5 cm, and is not easily cracked / broken. Within a year the amount of Waste lumber skin than can be processed by UD.Sumarni as many as 360 trucks equivalent to 5.184 sm. Of waste treatment is obtained revenue amounted to Rp. 890.400.000,- with a total cost of Rp. 744.530.000,- in order to obtain a gain of Rp. 145.870.000,- per year or Rp. 458.710,69 per m³ and break even point was 67.78 m³ or Rp. 188.190.476,19 per year. In order for the processing of waste lumber skin got gain, then UD.Sumarni should result in the production of over 67,78 m³ per year or earn an income above Rp. 188.190.476,19 per year.
ANALISIS SIKAP PETANI TERHADAP PROGRAM SEKOLAH LAPANG-PENGELOLAAN TANAMAN TERPADU (SL-PTT) PADI DI KOTA PALOPO
Authors: Intisari Intisari , Halik Hamja Abdul 
Published: October 2022

Sikap menyebabkan orang-orang berperilaku secara cukup konsisten terhadap suatu obyek. Sikap menggambarkan pula kecenderungan dari seseorang untuk melakukan tindakan tertentu yang berkaitan dengan objek sikap. SL-PTT adalah sebuah program yang dikeluarkan oleh pemerintah untuk mengembangkan kemampuan petani dalam mengolah lahan pertaniannya sehingga bisa meningkatkan kesejahteraan petani. Apa yang diajarkan di sekolah lapang ini tentunya diharapkan dapat diaplikasikan dalam kegiatan usahataninya. Ilmu yang diperoleh dalam sekolah lapang dapat ditransfer ke petani lainnya untuk pengembangan bersama. Oleh karena itu, sangatlah penting jika pemerintah ingin mengembangkan dan memperbaiki pelaksanaan program ini dapat mempelajari sikap petani terhadap program SL-PTT Padi. Penelitian ini bertujuan untuk menganalisis sikap petani terhadap program SL-PTT Padi di Kota Palopo. Sampel dalam penelitian ini diambil secara acak dimana akan dipilih tiga orang petani per kelompok tani yang melaksanakan program SL-PTT Padi di Kota Palopo, yaitu 80 x 3 petani = 240 responden. Analisis data yang digunakan dalam penelitian ini adalah pengukuran sikap Model Fishbein dengan menggunakan model multiatribut yaitu :Attitudeo = å bi ei.Hasil penelitian menujukkan sikap petani terhadap Program SL-PTT Padi di Kota Palopo adalah 548,23 yang artinya positif atau suka, karena berada dalam inetrval 477,41 – 626,20 (positif / suka). Sikap ini bisa dipengaruhi oleh pengetahuan petani akan program tersebut, atau pengetahuan lainnya yang terkait dengan program tersebut. Pengetahuan atau informasi yang diperoleh petani tentang program ini atau kegiatan-kegiatan dalam program ini cukup baik, apakah itu diperoleh dari pengalaman pribadi atau informasi dari orang lain.
KARAKTERISTIK PADI LOKAL AROMATIK DI KECAMATAN SEKO
Authors: Arzam AR Taruna Shafa , Yasin Sitti Maryam , Sapareng Sukriming , Rino Rino , Idris Muh Yusuf , Yasmin Yasmin 
Published: October 2022

Penelitian ini bertujuan membedakan karakter aroma padi lokal Seko yang ditanam pada dataran tinggi. Penelitian dilaksanakan di Kecamatan Seko Kabupaten Luwu Utara Sulawesi Selatan. Pemilihan lokasi dilakukan secara sengaja setelah menilai kelayakan lokasi (Judgement Sampling). Data primer diperoleh secara langsung dari lapangan dengan mengamati dari kelima hamparan jenis padi lokal aromatik Seko. Pengujian aroma dilakukan dengan dua cara yaitu dimasak dan tabung reaksi. Pengamatan kedua terhadap karakteristik morfologi dan agronomi. Pengujian dengan metode dimasak menampilkan karakter aroma dengan golongan aromatik yang lebih banyak daripada aroma sedang, sedangkan pada pengujian metode tabung reaksi menampilkan golongan aromatik yang lebih sedikit karena faktor jumlah beras yang digunakan lebih sedikit sehingga aroma yang tercium menjadi lebih lemah. Padi lokal Seko memiliki sifat-sifat morfologis yang spesifik, mulai dari daun, batang, malai, gabah dan beras dengan rasa nasi wangi dan pulen. Dengan perbaikan teknik budidaya, potensi hasil dapat mencapai 5,2 sampai 7,0 t/ha GKP. Untuk pelestarian dan pengembangan lebih lanjut, diperlukan usaha penangkaran padi jenis ini agar tetap terjaga keberadaannya.
ADAPTASI KEBERAGAMAN VARIETAS TERHADAP PERTUMBUHAN DAN PRODUKSI PADA WILAYAH MARGINAL PERTANAMAN BAWANG MERAH (Allium ascalanicum L.)
Authors: Upe Ambo , Sau Tenri 
Published: October 2022

Penelitian bertujuan mendapatkan varietas dengan adaptasi luas yang mampu tumbuh dan menghasilkan produksi optimal pada lahan marginal pertanaman bawang merah, yang dapat meningkatkan kesejahteraan petani, mengurangi ketergantungan impor bawang merah, menjadi pengekspor bawang merah menuju kedaulatan pangan. Metode yang akan dipakai adalah metode Rancangan Acak Kelompok (RAK) yang teridiri dari lima varietas bawang merah sebagai perlakuan yaitu varietas Bima Brebes, Tajuk, Bauji, Super Philip, dan Lokal Enrekang. Setiap perlakuan diulang sebanyak tiga kali. Pengolahan data dengan SPSS Software, Versi 22, dan jika terdapat pengaruh yang nyata, maka dilakukan uji beda dengan Uji Duncan pada taraf α=0,05. Penelitian dilaksanakan pada lahan percobaan STIP Puangrimaggalatung Sengkang. Parameter yang diamati terdiri atas pertumbuhan dan produksi tanaman bawang merah. Hasil analisis menunjukan bahwa varietas bawang merah yang cukup adaptif adalah bawang merah varietas Bima Brebes dan mampu mengahasilkan rataan produksi sebesar 12.08 t ha-1
KAPASITAS ADAPTASI PETANI KAKAO TERHADAP PERUBAHAN IKLIM
Authors: Idawati Idawati , Fatchiya Fatchiya , Tjitropranoto Tjitropranoto 
Published: October 2022

Dampak perubahan iklim menjadi salah satu penyebab hama penyakit pada tanaman kakao semakin meningkat dan sulit terkendalikan, menjadi penyebab degradasi lahan dan akhirnya menurunkan produksi perkakaoan nasional. Tujuan penulisan adalah: (1) Menganalisis kapasitas adaptasi petani kakao terhadap perubahan iklim (2) Menganalisis adopsi inovasi penyuluhan terhadap perubahan iklim dan (3) Menganalisis usahatani kakao berkelanjutan terhadap perubahan iklim. Metode penulisan adalah kajian ilmiah studi literatur dengan teknik review dan sintesis berbagai hasil penelitian. Hasil yang diperoleh adalah (1) Beradaptasi dengan kondisi alam yang berubah membutuhkan suatu kapasitas adaptasi (adaptive capacity) petani kakao terhadap perubahan iklim dalam bentuk kemampuan adopsi inovasi transfer teknologi, kemampuan kelembagaan, kemitraan, modal sosial dan akses terhadap modal usaha; (2) Upaya adaptasi dibutuhkan proses penyuluhan sebagai proses adopsi ide, praktik atau objek dalam suatu proses pembelajaran perubahan perilaku yang dimulai dari pengetahuan, sikap dan keterampilan dan menerapkan inovasi (proses adaptasi); dan (3) Keberlanjutan usahatani kakao dalam meningkatkan produktivitas dengan cara meningkatkan keterampilan dan daya adaptasi petani terhadap perubahan iklim, penggunaan pupuk organik dan pestisida ramah lingkungan serta penguatan kelembagaan kelompok tani untuk membangun kesamaan persepsi, komitmen, dan keterpaduan antar-subsektor, pusat dan daerah pada lingkup pertanian dan stakeholder terkait
PERTUMBUHAN DAN PRODUKSI KEDELAI TERHADAP PEMBERIAN BOKASHI ECENG GONDOK DENGAN DUA JENIS AKTIFATOR
Authors: Asrijal Asrijal , Upe Ambo , Rahmawati Rahmawati , Sulfiani Sulfiani , Aslidayanti Aslidayanti 
Published: October 2022

Penelitian bertujuan untuk mengetahui pertumbuhan dan produksi kedelai terhadap pemberian bokashi eceng gondok dengan dua jenis aktifator. Penelitian dilaksanakan di Desa Leweng Kecamatan Takkalalla Kabupaten Wajo. Metode yang digunakan adalah Rancangan Acak Kelompok (RAK), terdiri atas tiga (3) perlakuan yaitu Tanpa Bokashi (b0), Bokashi 2 tha-1 dengan Aktivator EM4 (b1), dan Bokashi 2 tha-1 dengan Aktivator Tadabur (b2). Setiap perlakuan diulang sebanyak tiga kali sehingga jumlah kombinasi perlakuan sebanyak 9 kombinasi (9 petakan perlakuan). Hasil penelitian menunjukkah bahwa Rata-rata produksi kedelai per hektar aplikasi bokashi eceng gondok dengan aktifator EM4 sebanyak 0,80 ton perhektar, sedangkan aplikasi bokashi eceng gondok dengan aktifator Tadabur sebanyak 0,79 ton perhektar. Aplikasi bokashi eceng gondok dengan aktifator EM4 jauh lebih baik, dibandingkan dengan bokashi eceng gondok dengan aktifator Tadabur