bluuebunny/crossref_metadata_2025_split huggingface dataset:
Transverse Goldstone mode in holographic fluids with broken translations
Authors: Zhong Yuan-Yuan , Li Wei-Jia 
Published: June 2022

AbstractIn this paper we investigate the low energy shear modes in fluid systems with spontaneously broken translations by a specific holographic model. In absence of momentum relaxation, we find that there exist two decoupled gapless modes in the transverse channel, one of which is purely diffusive and the other corresponds to vortex like excitations. The diffusive mode is associated with the conservation of momentum and the vortex mode can be viewed as the Goldstone mode of the spontaneous symmetry breaking. Switching on an external source which breaks the translations explicitly but weakly, the would-be gapless modes both get relaxed and acquire a tiny mass gap. Finally, in the strong momentum relaxation regime, we find a (pseudo-)diffusive-to-sound crossover that is set by a momentum gap.
Semi-empirical relation to understand matter properties at neutron star interiors
Authors: Mallick Ritam , Kuzur Debojoti , Nandi Rana 
Published: June 2022

AbstractThe occurrence of quark matter at the center of neutron stars is still in debate. This study defines some semi-empirical parameters that try to quantify the presence and the amount of quark matter at star interiors. We find that one needs unusually accurate measurement to qualitatively deduce the occurrence of quark core at the center of stars by studying the compactness of a fast rotating star as a function of angular momentum. Nevertheless one can deduce the quark content of a static 1.4 solar mass star and extend it for a rotating star. The quark fractions in a star depend on the stiffness of the equation of state and the critical density for phase transition. As the phase transition from the neutron star to a hybrid star happens, the star shrinks, releasing significant energy. A massive neutron star usually collapses into a black hole if the phase transition happens at constant baryonic mass. Given a hadronic EoS, we have shown how one can have a critical mass of the neutron star and the corresponding maximum mass of the hybrid star for a given equation of state.
A lingua geral como identidade construida
Authors: Barros Maria Cândida D. M. , Borges Luiz C. , Meira Márcio 
Published: June 2022

Língua Geral, or Nheengatu, or Tupian origin, is analyzed as a Brazilian cultural trait, which was historically developed and generated hy different social and ethnic groups for purposes of communicating their interests. During the Brazilian colonial period, emphasis is placed on the Jesuit influence, whereby the Língua Geral was imposed upon the Indians as the "language o f the whites"; during the 19th century , Lingua Geral became known as a "Brazilian language" , hoth during the Cabanagem conflict in addition to being embraced hy the Brazilian intellectual Romanticist movement. Today lhe indigenous peoples or the Rio Negro region maintain Lígua Geral as a means of preserving their cultural identity.
A cultura dos terreiros. Um estudo de caso no candomblé na Bahia
Authors: Agier Michel 
Published: June 2022

By considering "candomblé" as the culture of a place , this article tries to surpass the simple opposition between the notion or "candomblé" as an ethnic religion, and lhe notion of "candomblé" as a service offered in an indistinct religious market. In the introduction, this attempt is situated within the theoretical framework of Afro-Brazilian studies, which is briefly reviewed. ln the case study, which is then presented (the "terreiro" in Vila Flaviana, Salvador, Bahia) , we try to give an account of tensions lying at the root of the cultural dynainics of the "terreiros". Studies based on the history or conversions and the social networks involved make it possible to evidence the internal conflicts which affect the interpretation of "candomblé"
Results of Arthroscopic Revision Rotator Cuff Repair for Failed Open or Arthroscopic Repair: A Prospective Multicenter Study on 100 Cases
Authors: Hackl Michael , Flury Matthias , Kolling Christoph , Nebelung Wolfgang , Krauss Christine A. , Kraemer Nils A. , Heuberer Philipp R. , Laky Brenda , Wellmann Mathias , Pastor Marc-Frederic , Imhoff Andreas B. , Reuter Sven , Anderle Georg , Agneskirchner Jens D. , Buess Eduard 
Published: June 2022

Background: Retears after rotator cuff repair (RCR) have been associated with poor clinical results. Meaningful data regarding the role of arthroscopic revision RCR are sparse thus far. Purpose/Hypothesis: To investigate results after arthroscopic revision RCR. We hypothesized that (1) arthroscopic revision RCR would lead to improved outcomes, (2) the clinical results would be dependent on tendon integrity and (3) tear pattern, tendon involvement, and repair technique would influence clinical and structural results. Study Design: Case series; Level of evidence 4. Methods: During a 40-month period, 100 patients who underwent arthroscopic revision RCR were prospectively enrolled in this multicenter study. Outcomes were evaluated preoperatively, at 6 months (6M), and at 24 months (24M) using the Constant score (CS), the Oxford Shoulder Score (OSS), and the Subjective Shoulder Value (SSV). Tendon integrity at 2 years was analyzed using magnetic resonance imaging. A total of 13 patients (13%) were lost to follow-up, and 14 patients (14%) had a symptomatic retear before the 24M follow-up. Results: All clinical scores improved significantly during the study period (CS: preoperative, 44 ± 16; 6M, 58 ± 22; 24M, 69 ± 19 points; OSS: preoperative, 27 ± 8; 6M, 36 ± 11; 24M, 40 ± 9 points; SSV: preoperative, 43% ± 18%; 6M, 66% ± 24%; 24M, 75% ± 22%) ( P < .01). At 2 years, a retear rate of 51.8% (43/83) and a surgical revision rate of 12.6% (11/87) were observed. Mean full-thickness tear size decreased from 5.00 ± 1.61 cm2 to 3.25 ± 1.92 cm2 ( P = .041). Although the Sugaya score improved from 4.5 ± 0.9 to 3.7 ± 1.4 ( P = .043), tendon integrity did not correlate with better outcome scores. Previous open RCR, involvement of the subscapularis, chondral lesions of Outerbridge grade ≥2, and medial cuff failure were correlated with poorer SSV scores at 2 years ( P≤ .047). Patients with traumatic retears had better CS and OSS scores at 2 years ( P≤ .039). Conclusion: Although arthroscopic revision RCR improved shoulder function, retears were frequent but usually smaller. Patients with retears, however, did not necessarily have poorer shoulder function. Patient satisfaction at 2 years was lower when primary open RCR was performed, when a subscapularis tear or osteoarthritis was present, and when the rotator cuff retear was located at the musculotendinous junction. Patients with traumatic retears showed better functional improvement after revision.
Practical constraint definition in safety schemes for artificial pancreas systems
Authors: Rodríguez-Sarmiento David L , León-Vargas Fabian , Garelli Fabricio 
Published: June 2022

Introduction: Artificial pancreas systems usually define an insulin-on-board constraint ([Formula: see text]) for safety schemes to limit the insulin infusion and avoid hypoglycemia during the closed-loop performance. Several methods have been proposed with impractical considerations requiring information from the prandial events or complex procedures for ambulatory use. Methods: This paper presents a simple method that consists of two novel rules that allow finding an [Formula: see text] based only on common clinical parameters that do not require patient intervention. The method robustness was evaluated using a control system coupled to a safety layer under demanding scenarios implemented on the FDA-approved simulator for preclinical studies. Results: The method maintains a safe performance, even in the face of interpatient variability, hybrid and fully automatic implementations of an artificial pancreas system, and uncertain settings. Both proposed rules work as effectively or even better and without the patient intervention than other methods that have already been clinically validated. Conclusion: This method can be used to define a constant [Formula: see text] that ensures performance and safety of the control system, even under scenarios with incorrect clinical data. Unlike other methods, this method only requires reliable information that is easily obtained from the patient, such as their total daily dose of insulin or body mass.
Aniline exposure activates receptor-interacting serine/threonineprotein kinase 1 and causes necroptosis of AML12 cells
Authors: Jin Shuo , Zhang Tong , Fu Xinyu , Duan Zhongliang , Sun Jianwen , Wang Yue 
Published: June 2022

With the increased use of aniline, potential impacts on human health cannot be ignored. The hepatotoxicity of aniline is largely unknown and the underlying mechanism remains unclear. Therefore, the aim of the present study was to investigate the hepatotoxicity of aniline and elucidate the underlying mechanism. AML12 cells were exposed to different concentrations of aniline (0, 5, 10, or 20 mM) to observe changes to reactive oxygen species (ROS) production and the expression patterns of necroptosis-related proteins (RIPK1, RIPK3, and MLKL). The potential mechanism underlying aniline-induced hepatotoxicity was explored by knockout of RIPK1. The results showed that aniline induced cytotoxicity in AML12 cells in a dose-dependent manner in addition to the production of ROS and subsequent necroptosis of AML12 cells. Silencing of RIPK1 reversed upregulation of necroptosis-related proteins in AML12 cells exposed to aniline, demonstrating that aniline-induced ROS production was related to necroptosis of AML12. Moreover, aniline promoted intracellular RIPK1 activation, suggesting that the RIPK1/ROS pathway plays an important role in aniline-induced hepatotoxicity. NAC could quench ROS and inhibit necroptosis. These results provide a scientific basis for future studies of aniline-induced hepatotoxicity for the prevention and treatment of aniline-induced cytotoxicity.
Evaluation of the Addition of Angiotensin II in Patients With Shock After Cardiac Surgery at a Veterans Affairs Medical Center
Authors: Bird Stephanie , Chand Mastian , Tran Trung Ly , Ali Shahid , Awad Samir S. , Cornwell Lorraine D. , Schutz Alexander , Jimenez Ernesto 
Published: June 2022

Background: Vasoplegic shock occurs in up to 37% of cardiac surgery patients. We investigated the use of angiotensin II for treating vasoplegic shock in these patients. Objectives: We assessed clinical outcomes and mortality in patients undergoing cardiac surgery at our center between March 1, 2018 and October 31, 2020 who developed vasoplegic shock, comparing those who received angiotensin II with those who did not. Methods: This was a retrospective chart review. Response to angiotensin II was defined as increase in or maintenance of mean arterial pressure (MAP) and decrease in background vasopressor dosage. Results: Angiotensin II was administered to 7 patients (postoperatively in 4 patients [57.1%]) with vasoplegic shock and baseline norepinephrine equivalent (NEE) of 0.49 ± 0.08 μg/kg/min; 12 patients with vasoplegic shock did not receive angiotensin II. Within 3 hours of angiotensin II administration, NEE decreased by 38.0 ± 33.1%. Angiotensin patients were more likely to newly require renal replacement therapy (66.7% vs 9.1%, P = 0.03) and had a longer, although not statistically significant, postoperative stay (23.1 vs 14.0 days, P = 0.16). Despite higher NEE requirements at baseline (0.49 vs 0.30, P = 0.03) and over the next 48 hours in the angiotensin group, no between-group differences in 7-day mortality (14.3% vs 0.0%, P = 0.37) or 30-day mortality (28.6% vs 8.3%, P = 0.52) were noted. Conclusion and Relevance: In patients who developed vasoplegic shock after cardiac surgery, angiotensin II administration allowed immediate dosage reductions of other vasopressors while maintaining MAP. Despite its small sample size, this study adds to the paucity of data in these patients and highlights future research needs.
Statins and Risk of Thrombosis in Critically ill Patients with COVID-19: A Multicenter Cohort Study
Authors: Al Harbi Shmeylan , Kensara Raed , Aljuhani Ohoud , Korayem Ghazwa B. , Altebainawi Ali F. , Al Harthi Abdullah , Vishwakarma Ramesh , Alenazi Alaa M. , Almutairi Abdulmajed , Alshaya Omar , Alraddadi Sultan , Al Sulaiman Tareq , Aldakkan Latifah , Mahboob Reem , Alaamer Kholoud , Alissa Abdulrahman , Hafiz Awatif , Aldhayyan Nada , Althewaibi Sara , Alenezi Farhan , Alkhotani Nadeen Y. , Alghamdi Sara A. , Alenazi Abeer A. , Al Sulaiman Khalid 
Published: June 2022

Purpose Coagulation abnormalities are one of the most important complications of severe COVID-19, which might lead to venous thromboembolism (VTE). Hypercoagulability with hyperfibrinogenemia causes large vessel thrombosis and major thromboembolic sequelae. Statins are potentially a potent adjuvant therapy in COVID-19 infection due to their pleiotropic effect. This study aims to evaluate the effectiveness of statins in reducing the risk of thrombosis among hospitalized critically ill patients with COVID-19. Methods A multicenter, retrospective cohort study of all critically ill adult patients with confirmed COVID-19 admitted to Intensive Care Units (ICUs) between March 1, 2020, and March 31, 2021. Eligible patients were categorized based on their usage of statins throughout their ICU stay and were matched with a propensity score. The primary endpoint was the odds of all cases of thrombosis; other outcomes were considered secondary. Results A total of 1039 patients were eligible; following propensity score matching, 396 patients were included (1:1 ratio). The odds of all thrombosis cases and VTE events did not differ significantly between the two groups (OR 0.84 (95% CI 0.43, 1.66), P = 0.62 and OR 1.13 (95% CI 0.43, 2.98), P = 0.81, respectively. On multivariable Cox proportional hazards regression analysis, patients who received statin therapy had lower 30-day (HR 0.72 (95 % CI 0.54, 0.97), P = 0.03) and in-hospital mortality (HR 0.67 (95 % CI 0.51, 0.89), P = 0.007). Other secondary outcomes were not statistically significant between the two groups except for D-dimer levels (peak) during ICU stay. Conclusion The use of statin therapy during ICU stay was not associated with thrombosis reduction in critically ill patients with COVID-19; however, it has been associated with survival benefits.
Social Disparities in the Management of Trigger Finger: An Analysis of 31 411 Cases
Authors: Brodeur Peter G. , Raducha Jeremy E. , Kim Kang Woo , Johnson Cameron , Rebello Elliott , Cruz Aristides I. , Gil Joseph A. 
Published: June 2022

Background: Cost and compliance are 2 factors that can significantly affect the outcomes of non-operative and operative treatment of trigger finger (TF) and both may be influenced by social factors. The purpose of this study was to investigate socioeconomic disparities in the surgical treatment for TF. Methods: Adult patients (≥18 years old) were identified using International Classification of Diseases 9 and 10 Clinical Modification diagnostic codes for TF and Current Procedural Terminology (CPT) procedural codes (CPT: 26055) in the New York Statewide Planning and Research Cooperative System database. Each diagnosis was linked to procedure data to determine which patients went on to have TF release. A multivariable logistic regression was performed to assess the likelihood of receiving surgery. The variables included in the analysis were age, sex, race, social deprivation index (SDI), Charlson Comorbidity Index, and primary insurance type. A P-value < .05 was considered significant. Results: Of the 31 411 TF patients analyzed, 8941 (28.5%) underwent surgery. Logistic regression analysis showed higher odds of receiving surgery in females (odds ratio [OR]: 1.108) and those with workers compensation (OR: 1.7). Hispanic (OR: 0.541), Asian (OR: 0.419), African American (OR: 0.455), and Other race (OR: 0.45) had decreased odds of surgery. Medicaid (OR: 0.773), Medicare (OR: 0.841), and self-pay (OR: 0.515) reimbursement methods had reduced odds of receiving surgery. Higher social deprivation was associated with decreased odds of surgery (OR: 0.988). Conclusions: There are disparities in demographic characteristics among those who receive TF release for trigger finger related to race, primary insurance, and social deprivation.
How I treat immune-mediated thrombotic thrombocytopenic purpura after hospital discharge
Authors: Akwaa Frank , Antun Ana , Cataland Spero R. 
Published: June 2022

Abstract
Immune-mediated thrombocytopenic purpura (iTTP) is a thrombotic microangiopathy characterized by an acquired ADAMTS13 deficiency as a result of the presence of an antibody inhibitor of ADAMTS13 leading to the formation of ultralarge von Willebrand multimers. Treatment of iTTP includes plasma exchange, high-dose glucocorticoids, rituximab, and, more recently, caplacizumab, to prevent the development of exacerbations. There is the risk of both relapse and long-term complications that include neurocognitive deficits and cardiovascular events that occur in patients in remission after recovery from an acute iTTP episode. Data on the risk factors for the development of these complications, the appropriate screening, and treatment are limited due to the paucity of research. This article is a review of the current understanding on the risk factors for exacerbation, relapse, and long-term complications of iTTP and discusses an approach to observing patients with iTTP after hospital discharge and during the long-term follow-up in the outpatient setting.
Facile synthesis of degradable DOX/ICG co-loaded metal–organic frameworks for targeted drug release and thermoablation
Authors: Liu Bei , Liu Xiaoning , Zhang Xiangyu , Wu Xi , Li Chuanbo , Sun Zhaogang , Chu Hongqian 
Published: June 2022

Abstract
Background
Despite the increasing interest in combination therapy for the treatment of cancer, controlled delivery of different therapeutics with high body-clearance efficacy and cancer cell specificity remained a great challenge. In this study, a novel codelivery system was synthesized through one-pot coordination-driven self-assembly of 2-methylimidazole, zinc ion and chemotherapeutic drug (doxorubicin, DOX), followed by a surface decoration of photothermal agent (indocyanine green, ICG). To improve the targeting specificity performance, folic acid-conjugated polyethylene glycol (FA-PEG) antennas was connected on the surface of nanoparticles.

Results
The hybrid nanoparticles keep stable under neutral physiological condition but decompose when exposed to acidic environment, resulting in the on-demand release of DOX and ICG for chemo-photothermal combined therapy. Moreover, by switching the initial large size (~ 94 nm) to an ultrasmall size (∼10 nm) in cancer cells, the nanoparticles hold great potential to avoid nanotoxicity for clinical applications.

Conclusions
This work provides a new strategy for co-delivery of different therapeutics for combined cancer therapy with high cancer cell specificity and low nanotoxicity.
GridScore: a tool for accurate, cross-platform phenotypic data collection and visualization
Authors: Raubach Sebastian , Schreiber Miriam , Shaw Paul D. 
Published: June 2022

Abstract
Background
Plant breeding and crop research rely on experimental phenotyping trials. These trials generate data for large numbers of traits and plant varieties that needs to be captured efficiently and accurately to support further research and downstream analysis. Traditionally scored by hand, phenotypic data is nowadays collected using spreadsheets or specialized apps. While many solutions exist, which increase efficiency and reduce errors, none offer the same familiarity as printed field plans which have been used for decades and offer an intuitive overview over the trial setup, previously recorded data and plots still requiring scoring.

Results
We introduce GridScore which utilizes cutting-edge web technologies to reproduce the familiarity of printed field plans while enhancing the phenotypic data collection process by adding advanced features like georeferencing, image tagging and speech recognition. GridScore is a cross-platform open-source plant phenotyping app that combines barcode-based systems with a guided data collection approach while offering a top-down view onto the data collected in a field layout. GridScore is compared to existing tools across a wide spectrum of criteria including support for barcodes, multiple platforms, and visualizations.

Conclusion
Compared to its competition, GridScore shows strong performance across the board offering a complete manual phenotyping experience.
Developing a bioinformatics pipeline for comparative protein classification analysis
Authors: Pelosi Benedetta 
Published: June 2022

Abstract
Background
Protein classification is a task of paramount importance in various fields of biology. Despite the great momentum of modern implementation of protein classification, machine learning techniques such as Random Forest and Neural Network could not always be used for several reasons: data collection, unbalanced classification or labelling of the data.As an alternative, I propose the use of a bioinformatics pipeline to search for and classify information from protein databases. Hence, to evaluate the efficiency and accuracy of the pipeline, I focused on the carotenoid biosynthetic genes and developed a filtering approach to retrieve orthologs clusters in two well-studied plants that belong to the Brassicaceae family: Arabidopsis thaliana and Brassica rapa Pekinensis group. The result obtained has been compared with previous studies on carotenoid biosynthetic genes in B. rapa where phylogenetic analysis was conducted.

Results
The developed bioinformatics pipeline relies on commercial software and multiple databeses including the use of phylogeny, Gene Ontology terms (GOs) and Protein Families (Pfams) at a protein level. Furthermore, the phylogeny is coupled with “population analysis” to evaluate the potential orthologs. All the steps taken together give a final table of potential orthologs. The phylogenetic tree gives a result of 43 putative orthologs conserved in B. rapa Pekinensis group. Different A. thaliana proteins have more than one syntenic ortholog as also shown in a previous finding (Li et al., BMC Genomics 16(1):1–11, 2015).

Conclusions
This study demonstrates that, when the biological features of proteins of interest are not specific, I can rely on a computational approach in filtering steps for classification purposes. The comparison of the results obtained here for the carotenoid biosynthetic genes with previous research confirmed the accuracy of the developed pipeline which can therefore be applied for filtering different types of datasets.