bluuebunny/crossref_metadata_2025_split huggingface dataset:
A case study on Hoeamsa Temple, Korea: technical examination and identification of pigments and paper unearthed from the temple site
Authors: Go InHee , Mun SeongWoo , Lee JangJon , Jeong HyeYoung 
Published: February 2022

Abstract
This study applied various scientific analyses to one fragment of paper and three pigments excavated from earthenware found in the Hoeamsa Temple site at Yangju, Korea, which is believed to have been built in the early twelfth century. Radiocarbon dating of the paper fragment suggests a manufacture date between 1460 and 1646 (at a 95% confidence interval). It was estimated to have been used during the early and middle period of the Joseon dynasty (1391–1776), when the Hoeamsa Temple site was rebuilt. In addition, by staining the fiber of the paper fragment with Graff “C” stain, the paper’s raw material was identified as paper mulberry through dislocation, cross-marking, and transparent membrane, which are characteristics of the bast fiber. Efforts were made to identify their material properties and manufacturing techniques of the three types of pigments. Color difference analysis was performed by distributing the pigments in large areas to reveal characteristic differences according to the color difference of the pigment. We found that green-type pigments are malachite and atacamite, red-type pigments are hematite based on the element Fe, and white-type pigments are quartz and muscovite based on the elements Si and Al. In addition, as the size distribution of the three types of pigments is wide and has a multi-peak distribution curve, it was concluded that the pigments were used without purification.
The performance of BERT as data representation of text clustering
Authors: Subakti Alvin , Murfi Hendri , Hariadi Nora 
Published: February 2022

AbstractText clustering is the task of grouping a set of texts so that text in the same group will be more similar than those from a different group. The process of grouping text manually requires a significant amount of time and labor. Therefore, automation utilizing machine learning is necessary. One of the most frequently used method to represent textual data is Term Frequency Inverse Document Frequency (TFIDF). However, TFIDF cannot consider the position and context of a word in a sentence. Bidirectional Encoder Representation from Transformers (BERT) model can produce text representation that incorporates the position and context of a word in a sentence. This research analyzed the performance of the BERT model as data representation for text. Moreover, various feature extraction and normalization methods are also applied for the data representation of the BERT model. To examine the performances of BERT, we use four clustering algorithms, i.e., k-means clustering, eigenspace-based fuzzy c-means, deep embedded clustering, and improved deep embedded clustering. Our simulations show that BERT outperforms TFIDF method in 28 out of 36 metrics. Furthermore, different feature extraction and normalization produced varied performances. The usage of these feature extraction and normalization must be altered depending on the text clustering algorithm used.
Acceptance and Commitment Therapy to support medication decision-making and quality of life in women with breast cancer: protocol for a pilot randomised controlled trial
Authors: Smith Samuel G. , Ellison Rachel , Hall Louise , Clark Jane , Hartley Suzanne , Mason Ellen , Metherell Jamie , Olivier Catherine , Napp Vicky , Naik Jay , Buckley Sarah , Hirst Charlotte , Hartup Sue , Neal Richard D. , Velikova Galina , Farrin Amanda , Collinson Michelle , Graham Christopher D. 
Published: February 2022

AbstractBackgroundAdherence to adjuvant endocrine therapy is affected by medication side-effects and associated distress. Previous interventions focused on educating women to enhance adherence have proved minimally effective. We co-designed an Acceptance and Commitment Therapy (ACT) intervention to enhance medication decision-making and quality of life by targeting a broader range of factors, including side-effect management and psychological flexibility. This study aims to establish key trial parameters, assess the acceptability of the intervention and the extent to which it can be delivered with fidelity, and to demonstrate “proof of principle” regarding its efficacy on primary and process outcomes.MethodsThe ACTION intervention includes an individual 1:1 ACT session followed by three group sessions involving 8–10 women and two practitioner psychologists. Participants are also provided with access to a website containing evidence-based methods for self-managing side-effects. The ACT sessions were adapted during the COVID-19 pandemic to be remotely delivered via video conferencing software. To evaluate the feasibility and acceptability of this intervention, a multi-site, exploratory, two-arm, individually randomised external pilot trial with a nested qualitative study will be undertaken. Eighty women with early stage breast cancer prescribed adjuvant endocrine therapy will be randomised (1:1) to receive treatment as usual or treatment as usual plus the ACTION intervention. The planned future primary outcome is medication adherence assessed by the ASK-12 measure. Progression to a phase III RCT will be based on criteria related to recruitment and follow-up rates, acceptability to patients, competency and fidelity of delivery, and proof of principle for change in medication adherence.DiscussionThis external pilot trial will be used to ascertain the feasibility of undertaking a future phase III RCT to definitively evaluate an ACT-based intervention to support medication taking behaviour and quality of life in women with early stage breast cancer on adjuvant endocrine therapy.Trial registrationISRCTN: 12027752. Registered 24 December 2020,https://doi.org/10.1186/ISRCTN12027752
A transcriptomic reevaluation of the accessory olfactory organ in Bichir (Polypterus senegalus)
Authors: Sakuma Atsuhiro , Zhang Zicong , Suzuki Eri , Nagasawa Tatsuki , Nikaido Masato 
Published: February 2022

AbstractFish possess one olfactory organ called the olfactory epithelium (OE), by which various chemical substances are detected. On the other hand, tetrapods possess two independent olfactory organs called the main olfactory epithelium (MOE) and vomeronasal organ (VNO), each of which mainly detects general odorants and pheromones, respectively. Traditionally, the VNO, so-called concentrations of vomeronasal neurons, was believed to have originated in tetrapods. However, recent studies have identified a primordial VNO in lungfish, implying that the origin of the VNO was earlier than traditionally expected. In this study, we examined the presence/absence of the VNO in the olfactory organ of bichir (Polypterus senegalus), which is the most ancestral group of extant bony vertebrates. In particular, we conducted a transcriptomic evaluation of the accessory olfactory organ (AOO), which is anatomically separated from the main olfactory organ (MOO) in bichir. As a result, several landmark genes specific to the VNO and MOE in tetrapods were both expressed in the MOO and AOO, suggesting that these organs were not functionally distinct in terms of pheromone and odorant detection. Instead, differentially expressed gene (DEG) analysis showed that DEGs in AOO were enriched in genes for cilia movement, implying its additional and specific function in efficient water uptake into the nasal cavity other than chemosensing. This transcriptomic study provides novel insight into the long-standing question of AOO function in bichir and suggests that VNO originated in the lineage of lobe-finned fish during vertebrate evolution.
How to achieve an optimal alignment in medial opening wedge high tibial osteotomy?
Authors: Kang Byoung Youl , Lee Do Kyung , Kim Hyeon Soo , Wang Joon Ho 
Published: February 2022

AbstractMedial opening wedge high tibial osteotomy (MOWHTO) is a widely used surgical treatment option for medial compartmental osteoarthritis with varus deformity. It is important that proper lower limb alignment is achieved. However, there has been no consensus about an optimal alignment in MOWHTO. Most studies suggest that achieving valgus alignment is necessary, and recent studies support slight valgus mechanical alignment of less than 3° of mechanical femorotibial angle. Overcorrection and undercorrection is not recommended for achieving good surgical outcomes. To prevent undercorrection and overcorrection in MOWHTO, the method of placing the weight-bearing line in the target range must be precise. There are several ways to place a weight-bearing line within the target range. While the most important factor for a successful MOWHTO is achieving an ideal mechanical axis correction, there are a few other factors to consider, including joint line obliquity, posterior tibial slope, ligament balancing, and patellar height. Several factors exist that lead to undercorrection and overcorrection. Preoperative amount of varus deformity, lateral hinge fracture, and fixation failure can result in undercorrection, while medial soft tissue laxity and the amount of correction angle and target point beyond hypomochlion can result in overcorrection. This study aimed to review the literature on optimal alignment in MOWHTO and report on the factors to be considered to prevent correction errors and how to achieve an optimal alignment.
Evolution of cooperation in prisoner's dilemma game under the coupling of aspiration and imitation rules
Authors: Wang XiaoLin , Li Cong , Fan SuoHai 
Published: February 2022

Abstract
Considering the important roles played by aspiration and imitation rules, we explore how cooperation evolves in the spatial prisoner's dilemma game. In detail, the strategy updating rule couples the inner aspiration payoff and the external neighborâs payoff through the parameter α. Intriguingly, we find that there exists an optimal value of α leading to the highest density of cooperators for each aspiration level A. By analyzing the dynamical strategy changes of the system, we find that an optimal α helps individuals form cooperator clusters and curbs the further spread of high-payoff defectors, and thus improves the density of cooperators. Moreover, when

, the optimal value of α, which leads to the highest density of cooperators, decreases with A, the optimal range of α gradually expands and the highest cooperation level is on the rise.
The world beyond physics: How big is it?
Authors: Succi Sauro 
Published: February 2022

Abstract
We discuss the possibility that the complexity of biological systems may lie beyond the predictive capabilities of theoretical physics: in Stuart Kauffman's words, there is a World Beyond Physics (WBP). It is argued that, in view of modern developments of statistical mechanics, the WBP is smaller than one might anticipate from the standpoint of fundamental physical theories.
Managing Central Nervous System Tumors During Pregnancy
Authors: Gatson Na Tosha N. 
Published: February 2022

ABSTRACT

PURPOSE OF REVIEW
This article discusses current recommendations and special considerations for the management of central nervous system (CNS) tumors in pregnant women and provides case vignettes to emphasize important clinical concepts.

RECENT FINDINGS
Given that nearly 60% of all intracranial and spinal cord tumors, including both primary and metastatic tumor types, malignant or benign, are diagnosed in women, it is equitable to bring attention to the unique management considerations that pertain to women during specific phases of their lifespan, such as pregnancy. The pregnancy phase is marked by changes in hormonal, immunologic, and other physiologic responses. Although substantial evidence supports a pregnancy influence on tumor oncogenicity, the cumulative effect of the pregnancy state on brain tumor biology remains elusive. Furthermore, as innovative cancer treatments and surveillance technologies expand, providers must consider potential new risks to safe pregnancy maintenance. This article reviews pregnancy considerations in CNS tumor care and offers best practice approaches and considerations.

SUMMARY
Informed neuro-oncology practices on safer surgical, radiation, medical, device, and imaging techniques is of critical importance to pregnancy and fertility maintenance in cancer survivors. Expanding this knowledge relies on advocacy and a commitment to develop equitable and multidisciplinary research within the field. This also requires a focus on patient-reported outcomes and patient-centered conversations to best care for pregnant women with CNS tumors.
Revascularization Is Associated With a Reduced Stroke Risk in Patients With Sickle Cell–Associated Moyamoya Syndrome
Authors: Newman Sarah , McMahon J. Tanner , Boulter Jason H. , Malcolm James G. , Revuelta Barbero Juan M. , Chern Joshua J. , Barrow Daniel L. , Pradilla Gustavo 
Published: February 2022

BACKGROUND:
Moyamoya syndrome refers to a progressive stenosis of the internal carotid arteries and can be associated with sickle cell disease. These codiagnoses result in severe risk for stroke, even in patients on optimal medical management. Surgical revascularization has been shown to be safe in small case series.

OBJECTIVE:
To evaluate the efficacy of revascularization with direct comparison to a medically managed control group within a single institution.

METHODS:
A retrospective cohort study of medically managed vs surgically revascularized patients with moyamoya syndrome and sickle cell disease was conducted. Demographic data and outcomes including the number of prediagnosis, postdiagnosis, and postrevascularization strokes were collected. Risk factors for stroke were identified using a binary logistic regression model, and stroke rates and mortality between groups were compared.

RESULTS:
Of the 29 identified patients, 66% were medically managed and 34% underwent surgical revascularization (50% direct and 50% indirect). Calculated stroke rates were 1 per 5.37 (medical management), 1 per 3.43 (presurgical revascularization), and 1 per 23.14 patient-years (postsurgical revascularization). There was 1 surgical complication with no associated permanent deficits. No risk factors for stroke after time of diagnosis were found to be significant.

CONCLUSION:
The results of this study demonstrate that revascularization is associated with a significant reduction in stroke risk, both relative to prerevascularization rates and compared with medical management. According to these findings, surgical revascularization offers a safe and durable preventative therapy for stroke and should be pursued aggressively in this patient population.
Anatomy and development of the pectoral fin vascular network in the zebrafish
Authors: Paulissen Scott M. , Castranova Daniel M. , Krispin Shlomo M. , Burns Margaret C. , Menéndez Javier , Torres-Vázquez Jesús , Weinstein Brant M. 
Published: February 2022

ABSTRACT
The pectoral fins of teleost fish are analogous structures to human forelimbs, and the developmental mechanisms directing their initial growth and patterning are conserved between fish and tetrapods. The forelimb vasculature is crucial for limb function, and it appears to play important roles during development by promoting development of other limb structures, but the steps leading to its formation are poorly understood. In this study, we use high-resolution imaging to document the stepwise assembly of the zebrafish pectoral fin vasculature. We show that fin vascular network formation is a stereotyped, choreographed process that begins with the growth of an initial vascular loop around the pectoral fin. This loop connects to the dorsal aorta to initiate pectoral vascular circulation. Pectoral fin vascular development continues with concurrent formation of three elaborate vascular plexuses, one in the distal fin that develops into the fin-ray vasculature and two near the base of the fin in association with the developing fin musculature. Our findings detail a complex, yet highly choreographed, series of steps involved in the development of a complete, functional, organ-specific vascular network.
PRDM paralogs antagonistically balance Wnt/β-catenin activity during craniofacial chondrocyte differentiation
Authors: Shull Lomeli C. , Lencer Ezra S. , Kim Hyun Min , Goyama Susumu , Kurokawa Mineo , Costello James C. , Jones Kenneth , Artinger Kristin B. 
Published: February 2022

ABSTRACT
Cranial neural crest cell (NCC)-derived chondrocyte precursors undergo a dynamic differentiation and maturation process to establish a scaffold for subsequent bone formation, alterations in which contribute to congenital birth defects. Here, we demonstrate that transcription factor and histone methyltransferase proteins Prdm3 and Prdm16 control the differentiation switch of cranial NCCs to craniofacial cartilage. Loss of either paralog results in hypoplastic and disorganized chondrocytes due to impaired cellular orientation and polarity. We show that these proteins regulate cartilage differentiation by controlling the timing of Wnt/β-catenin activity in strikingly different ways: Prdm3 represses whereas Prdm16 activates global gene expression, although both act by regulating Wnt enhanceosome activity and chromatin accessibility. Finally, we show that manipulating Wnt/β-catenin signaling pharmacologically or generating prdm3−/−;prdm16−/− double mutants rescues craniofacial cartilage defects. Our findings reveal upstream regulatory roles for Prdm3 and Prdm16 in cranial NCCs to control Wnt/β-catenin transcriptional activity during chondrocyte differentiation to ensure proper development of the craniofacial skeleton.
Behavioural analysis of swarming mosquitoes reveals high hearing sensitivity in Anopheles coluzzii
Authors: Feugère Lionel , Roux Olivier , Gibson Gabriella 
Published: February 2022

ABSTRACT
Mosquitoes of many species mate in station-keeping swarms. Mating chases ensue as soon as a male detects the flight tones of a female with his auditory organs. Previous studies of hearing thresholds have mainly used electrophysiological methods that prevent the mosquito from flying naturally. The main aim of this study was to quantify behaviourally the sound level threshold at which males can hear females. Free-flying male Anopheles coluzzii were released in a large arena (∼2 m high×2 m×1 m) with a conspicuous object on the ground that stimulated swarming behaviour. Males were exposed to a range of natural and synthetic played-back sounds of female flight. We monitored the responses of males and their distance to the speaker by recording changes in their wingbeat frequency and angular speed. We show that the mean male behavioural threshold of particle velocity hearing lies between 13 and 20 dB sound particle velocity level (SVL) (95% confidence interval). A conservative estimate of 20 dB SVL (i.e. &lt;0.5 µm s−1 particle velocity) is 12–26 dB lower than most of the published electrophysiological measurements from the Johnston's organ. In addition, we suggest that (1) the first harmonic of a female’s flight sound is sufficient for males to detect her presence, (2) males respond with a greater amplitude to single-female sounds than to the sound of a group of females and (3) the response of males to the playback of the flight sound of a live female is the same as to that of a recorded sound of constant frequency and amplitude.
Scopus based bibliometric and scientometric analysis of occupational therapy publications from 2001 to 2020
Authors: Sau Koushik , Nayak Yogendra 
Published: February 2022

Background: Occupational therapy (OT) is one of the allied health professions that had its first journals way back in 1920. The main objective of this study was to find out the publication trend in the field of OT research for the period of 2001-2020 using the principles of bibliometrics and scientometrics. Methods: The data was retrieved from Scopus from the past 20-years (2001-2020). VOSviewer software was used to find year-wise publications in OT-specific and non-OT-specific Journals along with top journals, countries, organisations, authors, cited articles, and highly used keywords. Results: There was a steady growth of OT articles from the past 20-years. Scopus indexes 16 OT-specific journals are identified. American Journal of Occupational Therapy, British Journal of Occupational Therapy Journal, Australian Occupational Therapy Journal, Scandinavian Journal of Occupational Therapy and Canadian Journal of Occupational Therapy are the leading publications and citations. Comparison of OT-specific and non-OT journals inferred that the OT-specific papers are three times more published in non-OT journals. There is a trend in publishing multidisciplinary medical journals than OT journals. The US publishes the highest number of articles, followed by the UK, Australia, Canada, and Germany. Though the US alone produced a considerable number of articles (9517), only five organisations are listed in the top-20, compared to Canada (n=6) and Australia (n=5). Australia represents the highest published authors (n=11/20), and Canada represents a highly cited author from the top-cited publications. The “occupational therapy”, “rehabilitation”, “stroke”, “physical therapy,” and “activities of daily living” are the five common keywords used by OT authors. This study lists top-20 journals along with their CiteScore and Journal Impact Factor. Conclusions: This study will help the budding researchers in OT to select a suitable quality journal for publication and, further, helpful for research promotion, researcher incentivising, grant allocations, and policymakers in the OT field.
Mucosal microbiome is predictive of pediatric Crohn’s disease across geographic regions in North America
Authors: Shah Rajesh , Hoffman Kristi , Denson Lee , Kugathasan Subramaniam , Kellermayer Richard 
Published: February 2022

Background: Patients with Crohn’s disease (CD) have an altered intestinal microbiome, which may facilitate novel diagnostic testing. However, accuracy of microbiome classification models across geographic regions may be limited. Therefore, we sought to examine geographic variation in the microbiome of patients with CD from North America and test the performance of a machine learning classification model across geographic regions. Methods: The RISK cohort included 447 pediatric patients with CD and 221 non-inflammatory bowel disease controls from across North America. Terminal ileum, rectal and fecal samples were obtained prior to treatment for microbiome analysis. We divided study sites into 3 geographic regions to examine regional microbiome differences. We trained and tested the performance of a machine learning classification model across these regions. Results: No differences were seen in the mucosal microbiome of patients with CD across regions or in either the fecal or mucosal microbiomes of controls. Machine learning classification algorithms for patients with CD performed well across regions (area under the receiver operating characteristic curve [AUROC] range of 0.85-0.91) with the best results from terminal ileum. Conclusions: This study demonstrated the feasibility of microbiome based diagnostic testing in pediatric patients with CD within North America, independently from regional influences.