bluuebunny/crossref_metadata_2025_split huggingface dataset:
Investigation of Fracture Prevention Effects of Composite Patches Repair on Cracked Al-Plates: Experimental and Numerical study
Authors: Ranjbaran Mohammadjavad 
Published: June 2022

Abstract
Today’s cutting-edge world of science and technology calls for composite materials to be widely employed in numerous industries, including marine, aeronautical and automotive due to their excellent mechanical, chemical and thermal characteristics. In various engineering applications composite materials are cost-effective, reliable, life saver and efficient. By reducing the strength-to-weight ratio by significant amounts, composite materials have revolutionized the manufacturing process of aircrafts. In the present research, 50 rectangular cracked aluminum alloy 7075 specimens with central crack were repaired by glass-epoxy composite patches with 0,90 and-45,+45 fibers orientations. Then, the specimens were subjected to uniaxial tensile loading test experimentally using the 600KN Santam testing machine. Next, the force-displacement curve for each repaired sample was monitored and plotted by the testing machine user’s software. After that, Abaqus as a finite element software was employed to numerically simulate and perform the tensile test with XFEM method on developed three-dimensional models. Lastly, the experimental and numerical results were validated and compared precisely. It was concluded that XFEM as an effective technique is capable of predicting crack propagation with maximum 0.0266 error percentage. Moreover, specimens repaired by glass-epoxy with 0,90 fibers orientation have the optimum performance while the ones whose fibers orientation is -45,+45 extended more before failure.
Cytoprotective effect and clinical outcome of perioperative progesterone in brain tumors. A novel randomized mono-centeric microscopic evidence based research.
Authors: Raouf Mina Maher , naguib Mohab Mohamad , nanous walid zeidan , Hanna. George Abdel-shaheed , Gayd Marian Fathi , mohamad omyma shehata 
Published: June 2022

Abstract
Objectives.The primary end-point of the current study was to to provide contemporary estimate about both cytoplasmic and nuclear effects of intramuscular progesterone therapy prior to craniotomy. Secondary end-points were to track post-operative course and short term (3 months) neurological sequele.Measurments.Cellular neuronal microscopic examination by immuno-histochemistry (Progesterone receptor density ) and by H&E. Allred score for nuclear staining for PR receptors . Post-operative course included time to wean from mechanical ventilation (hours), Length of ICU stay (days) and brain neuro-imaging by brain CT). Short term outcome included sensory, motor and autonomic assessment. Patients.Two hundred fifty two (252) adult patients of both sexes aged 18–60 years, American society of anesthesia (ASA class І-ІІ ) candidate for intra-parenchymal intra-axial elective brain tumors resection , Excluded candidates included refusal to sign document for intervention, urgent craniotomy, history of endometrial or ovarian neoplasia, redo craniotomy, stented coronary arteries or history of deep venous thrombosis. Design. This research was a randomized, double-blind, placebo controlled single center study. Intervention. Two groups, the control group and Progesterone (PR) group. PR group received 1mg/ kg intramuscular progesterone five days before and five days after craniotomy, while Control group received intramuscular isotonic saline daily, five days before and five days after surgery.Setting.Fixtures performed in Minia university hospital, Neurosurgery operative theatre, Floor two (non trauma floor). The study was registered in local ethical committee on April 2020. First patient enrollment was on first of June 2020 and the patient allocation in the rank ended on 30 of December 2020. Main resultsProgesterone therapy successfully increased expression of active nuclear PR receptors on oligodendrocytes and astrocytes, provided cytoplasmic and nuclear neuro-quiescence. Progesterone gave better neurological outcome on 3 month follow- up.Conclusions.Neuronal biopsy examination represented a leap in confirming anti-neuro-inflammatory action offered by progesterone.
Unnamed Autofictions, Dissonant Co-labouring: a preface
Authors: Co-Labouring  
Published: June 2022

This preface to our keygroup conference contribution addresses the problem of collaboration and the autofictions that sustain co-labouring: working together in difficult conditions. It contains three registers of writing. Excerpts of autofictions reveal the slippery implications of contemporary collective labour in UK higher education. Questions punctuate the text to invite the reader into the problematics that sustain our working. Theory through narrative begins to articulate the ways that might enable the support and interest necessary for dignity to be possible at work.
An efficient coupling algorithm of fluid structure interaction for marine propeller flow
Authors: Zhong Jize , Wei Zihan , Qiu Changlin , Yan Xiaojie , Sun Qibin 
Published: June 2022

An efficient coupling algorithm of fluid structure interaction for propeller flow has been proposed in this paper. Inner iterations for the flow analysis in the existing fluid structure coupling method were not needed any more while the flow, vibration of the propeller and the flow mesh deformation were solved using iterations called single-loop iteration to reduce the computing time. Fluid structure coupled computations were performed for a propeller blade. Results show that the vibration of the rotating blade is excited by its hydrodynamic force and the vibration of the 1st mode is the dominant. The vibration of the blade attenuates versus time and the blade finally stabilizes at the equilibrium position. The computing time is reduced by 88.4 % using the present algorithm in this paper compared with the existing fluid structure coupling method.
Network Pharmacology-based Strategy to Investigate Pharmacological
Mechanisms of Qingbutongluo Pill for Treatment of Brucellosis
Authors: Zhou Wei-Gang , Wang Jing , He Jia-Wei , Liu Ji-Shan , Li Jian-E , Cui Qing-You , Wang Yi-Rui 
Published: June 2022

Background and Objectives:
Qingbutongluo pill (QBTLP), a Chinese herbal preparation,
has been developed to treat brucellosis for many years with a good therapeutic effect. This
study preliminarily explored its potential molecular mechanisms against brucellosis through network
pharmacology.

Methods:
The active ingredients of QBTLP were screened out mainly from the Traditional Chinese
medicine systems pharmacology database and analysis platform (TCMSP), and their potential
targets were predicted through the PubChem database and Swiss Target Prediction platform.
GeneCards, DisGeNET， Digsee， and the Comparative Toxicogenomics Database (CTD) searched
the targets corresponding to brucellosis. Then, the Venn diagram obtained intersection targets of
QBTLP and diseases. Protein-protein interaction (PPI) network analysis was performed using the
Search Tool for the Retrieval of Interacting Genes database (STRING) and visualized in Cytoscape
software. Module analysis of the PPI network and core target identification was performed using
the Molecular Complex Detection (MCODE) and the Cytohubba plugins. The Metascape data platform
was used to perform Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes
(KEGG) pathway enrichment analysis on the intersection targets, and then the “active ingredientstargets-
pathways” network was constructed using Cytoscape to screen key active ingredients.

Results:
19 key active ingredients were identified by network pharmacological, including Baicalein,
Cryptopin, etc. The core targets of QBTLP for treating brucellosis contained TNF, TLR4,
MAPK3, MAPK1, MAPK8, MAPK14, MMP9, etc. And the main pathways included the Toll-like
receptor signaling pathway, NOD-like receptor signaling pathway, TNF signaling pathway, MAPK
signaling pathway, Th17 cell differentiation, and IL-17 signaling pathway.

Conclusions:
This study explored the mechanisms of QBTLP for treating brucellosis, which may
provide a scientific basis for the clinical application of QBTLP.
Saikosaponin-A Exhibits Antipancreatic Cancer Activity by Targeting the
EGFR/PI3K/Akt Pathway
Authors: Li Qiang , Shi Chengda , Sun Linglin , Fang Rong , Zheng Shuying , Yu Mingming 
Published: June 2022

Background:
A diagnosis of pancreatic cancer is pretty grim. Saikosaponin-A (SSA) is
a Chinese herbal extract with anticancer activity. However, the therapeutic effect of SSA on pancreatic
cancer remains elusive.

Aim:
The study aims to evaluate the antitumor effects of SSA on pancreatic cancer cells in vitro
and in vivo.

Methods:
After treatment with SSA, cell viability was measured using the CCK-8 assay, DAPI
staining was performed to analyze the effect on nuclear morphology, propidium iodide (PI) staining
was used to detect the cell cycle, and Annexin V/PI double staining was conducted to analyze
apoptosis. Then, the expression of apoptosis-related proteins and EGFR/PI3K/Akt pathway-related
proteins was determined using western blotting. The binding of SSA to EGFR was analyzed by
performing molecular docking. The mouse pancreatic cancer model was established by subcutaneously
injecting pancreatic cancer cells, and after 30 days of SSA gavage, the tumor volume was
calculated. Tumor tissue sections were subjected to Ki67 immunohistochemical staining and HE
staining.

Results:
SSA inhibited the proliferation of pancreatic cancer cells. As the concentration of SSA
increased, the proportions of BxPC-3 and MIA PaCa-2 cells in the G0/G1 phase increased, the
proportions of early and late apoptotic cells also increased, and the apoptosis rate gradually increased.
Apoptosis inhibitor experiments indicated that SSA promoted the activation of caspase 3
to induce apoptosis in pancreatic cancer cells. In addition, SSA treatment significantly reduced the
levels of phosphorylated EGFR, Akt, and PI3K in the two cell lines. Molecular docking results
showed that SSA may have potential binding sites in EGFR. Results of the xenograft experiment
confirmed the antitumor effects of SSA, as evidenced by the decreased tumor weight and downregulated
expression of Ki67.

Conclusions:
The results revealed that SSA exerted inhibitory effects on pancreatic cancer cells.
These effects may be related to the inactivation of the EGFR/PI3K/Akt signalling pathway.
Metabolic Syndrome in Behçets Disease Patients: Keep an Eye on the Eye
Authors: Gheita Tamer A. , ElAdle Suzan S. , Latif Eiman Abdel , Abdel-Fattah Yousra H. , Shebini Emad El , El-Gazzar Iman I. , El-Saadany Hanan M. , Samy Nermeen , El-Mallah Reem , Salem Mohamed N. , Eesa Nahla , Shereef Rawhya El , El Khalifa Marwa , Tharwat Samar , Nasef Samah I. , Ibrahim Maha Emad , Khalil Noha M. , Abdalla Ahmed M. , Abd Elazeem Mervat I. , Noor Rasha Abdel , Sallam Rehab , El-Bahnasawy Amany , Shanawany Amira El , Senara Soha , Fathi Hanan M. , Bakry Samah A. El , Elsaman Ahmed , Najjar Amany El , Ragab Usama , Talaat Esraa A. , Hammam Nevin , El-Hindawy Aya K. , Ismail Faten 
Published: June 2022

Background:
Metabolic syndrome (MetS) is characterized by insulin resistance, high blood pres-sure/sugar, dyslipidemia, and obesity. Whether MetS and its components affect the development of Behçet's Disease (BD) remains unclear.

Aims:
The aim was to determine the frequency of MetS among BD patients and to study its relationship with disease characteristics.

Methods:
The study included 1028 adult BD patients recruited from 18 specialized rheumatology centers. 51 healthy matched control were considered. Behçet Disease Current Activity Form (BDCAF) and the BD damage index (BDI) were estimated. Adult Treatment Panel-III criteria were used to define MetS.

Results:
The mean age of patients was 36.8 ± 10.1 years, M:F 2.7:1 and disease duration 7.01 ± 5.2 years. Their mean BDCAF was 5.1 ± 4.6 and BDI 5.5 ± 2.8. MetS was present in 22.8% of patients and in 5.9% of control (3.9 fold higher-risk). Patients with MetS had a significantly increased age at onset (31.8 ± 9.2 vs. 29 ± 8.5 years) and higher frequency of genital ulcers (96.2% vs. 79.7%), skin involvement (73.1% vs. 50.4%), arthritis (48.3% vs. 29.1%) (p<0.0001) and CNS manifestations (18.8% vs. 13%) (p=0.042) compared to those without it. Eye involvement was significantly increased in those with MetS (82.1% vs. 74.2%) (p=0.003) with increased frequency of posterior uveitis (67.1% vs. 43.5%), retinal vessel occlusion (35.9% vs. 21.3%), retinal vasculitis (41.9% vs. 26.4%) (p<0.0001) and vitritis (37.2% vs. 24%) (p=0.001). BDCAF was significantly lower (3.9 ± 4.3 vs. 5.6 ± 4.6) and BDI higher (7.4 ± 2.7vs5 ± 2.6) (p<0.0001).

Conclusion:
BD patients with MetS are predisposed to mucocutaneous, musculoskeletal, neuropsychiatric and ocular manifestations with consequently increased damage. The involvement of the deeper structures of the eye should alarm rheumatologists to keep in mind that all patients should have an eye examination, especially those with MetS.
A Case of Wild-type Cardiac Transthyretin Amyloidosis Diagnosed by
Non-invasive Methods
Authors: Lizarazo Ortega David Andrés , Valderrama Bibiana Pinzón , González-Robledo Gina , Trujillo Patricia Bernal 
Published: June 2022

Introduction:
Transthyretin amyloid cardiomyopathy was considered a rare pathology.
However, recent studies show a significant prevalence in patients with degenerative aortic stenosis and
heart failure with preserved ejection fraction.

Case Presentation:
An 85-year-old woman presented with a four-month history of pain in the rib cage
with a history of diffuse large B-cell lymphoma of the oral cavity, essential thrombocytosis and
dyslipidemia. She had no significant family history. A transthoracic echocardiogram showed
degenerative aortic stenosis and normal systolic function with preserved left ventricular ejection
fraction of 70%. Bone-avid tracer cardiac scintigraphy with technetium-99m-labeled hydroxymethylene
diphosphonate with SPECT-CT documented grade two myocardial uptake according to the
Perugini scale. MRI evidenced late patchy enhancement in the myocardium associated with diffuse
subendocardial enhancement. Laboratory tests showed the absence of mutation in the transthyretin
(TTR) gene, serum and urine immunofixation electrophoresis (IFE) negative for monoclonal protein
and serum-free light chain (sFLC) assay with a normal kappa/lambda (K/L) ratio. All these findings
were compatible with a non-invasive diagnosis of wild-type cardiac amyloidosis.

Conclusion:
The accepted criteria for the definitive non-invasive diagnosis of amyloid
cardiomyopathy are based on myocardial uptake by scintigraphy (with SPECT), serum and urine
immunofixation electrophoresis, serum-free light chain assay and suggestive findings on
echocardiography and/or MRI. Genetic testing should differentiate between ATTRv (v for variant) and
ATTRwt (wt for wild type) forms.
Simple and Rapid LC-MS/MS Method for Determination of Perampanel
in Human Plasma and Application to Bioequivalence Study
Authors: Zou Qiao-gen , Gao Pan 
Published: June 2022

Background:
Perampanel (PER) is a third-generation antiepileptic drug (AED). Several
methods have been developed for the quantification of perampanel in plasma. The pharmacokinetic
characteristics of perampanel in healthy Chinese ubjects have not been comprehensively
reported.

Objective:
A simple, fast and sensitive LC-MS/MS method was established and validated for the
quantification of perampanel in human plasma and its application to a bioequivalence study.

Methods:
Chromatographic separation was accomplished on a ZORBAX Eclipse XDB-Phenyl
column (4.6 mm × 75 mm, 3.5 μm) using a binary gradient with mobile phase (A) (water containing
5 mmol/L ammonium acetate and 0.1% formic acid and (B) acetonitrile-water (95:5, v/v) at a
flow rate of 0.9 mL/min and sample preparation was by one-step protein precipitation via acetonitrile.

Results:
The total run time in this study was 4.5 min and the retention time of perampanel and
perampanel-d5 (internal standard) were 2.30 min and 2.32 min, respectively. The method was developed
and validated over the concentration range of 2.00-500 ng/mL for perampanel, with a
correlation coefficient greater than 0.9992. The inter-day precision was 3.1%-3.8% and accuracy
was 98.9%-103.5%. The intra-day precision was 2.4%-6.8% and the accuracy was 97.6%-
104.9%. The extraction recovery ranged from 99.23%-103.84% and the matrix effect was not
significant. Perampanel was proved to be stable in solution and human plasma under different
tested conditions. The validated method was successfully applied to a randomized, open-label, 2-
period, crossover bioequivalence study in healthy Chinese subjects, and the results indicated that
bioequivalence was achieved for 2 formulations of the 4-mg perampanel tablet under both fasting
and fed conditions, and both treatments were safe and well-tolerated by all study subjects.

Conclusion:
The validated method was successfully applied to a bioequivalence study of perampanel
in human plasma and has achieved satisfactory results.
Successful Pre-Clinical Management of Irinotecan-Debilitated Animals: A Protein-
Based Accessory Phytomedicine
Authors: Rangel Gisele F. P. , Ramos Márcio V. , do Carmo Luana D. , Rabelo Liviane M. A. , Silva Alfredo A. V. , de Sousa Tamiris F. G. , Lima Júnior Roberto C. P. , Wong Deysi V. T. , Leitão Renata F. C. , Magalhães Pedro J. C. , Sousa Brandon F. , Frederico Marisa J. S. , Alencar Nylane M. N. 
Published: June 2022

Background:
Calotropis procera is a laticiferous plant (Apocynaceae) found in tropical regions all over the
world. The ultrastructural characteristics of laticifers, their restricted distribution among different taxonomic groups,
and in some species in each clade, as peptidases from latex, make them very attractive for biological analysis.

Objective:
The study aims to investigate the effects of LP-PII-IAA (laticifer protein (LP) sub-fraction II (PII) of C.
procera presenting an iodoacetamide-inhibited cysteine proteinase activity) on irinotecan-induced intestinal mucositis,
a serious adverse effect of this medicine for the treatment of cancer.

Methods:
LP-PII-IAA is composed of closely related isoforms (90%) of peptidases derived from catalysis and an osmotin
protein (5%). Animals receiving co-administration of LP-PII-IAA presented a significant decrease in mortality,
absence of diarrhea, histological preservation, and normalization of intestinal functions.

Results:
Clinical homeostasis was accompanied by a reduction in MPO activity and declined levels of IL-1β, IL-6 and
KC, while the IL-10 level increased in LP-PII-IAA-treated animals. COX-2 and NF-kB immunostaining was reduced
and the levels of oxidative markers (GSH, MDA) were normalized in animals that received LP-PII-IAA.

Conclusion:
We suggest that peptidases from the latex of Calotropis procera were instrumental in the suppression of
the adverse clinical and physiological effects of irinotecan.
An Analytical Model of Multi-intrusion Detection for Heterogeneous Wireless
Sensor Networks Applied in the Monitoring Area
Authors: Assad Noureddine , Moujahdi Chouaib , Hannani Asmaa El , Hanine Mohamed , Lachgar Mohamed 
Published: June 2022

Aim:
For a Wireless Sensor Network (WSN), the sensor node deployment is a critical issue
since it reflects the coverage quality. It is the most fundamental issue in WSNs, and it has a great effect
on the overall WSN application performance. When it is necessary to deploy randomly sensor
nodes in a field of interest to form a WSN, ensuring a high coverage quality becomes difficult. In the
random deployment scenario, the most difficult aspect of sensing coverage is to find how well the
sensor nodes cover the field of interest. In this paper, we analyze the intrusion detection in a WSN
which is defined as a mechanism for monitoring and detecting any intruder in a field of interest, with
the objective of enhancing the detection quality in a random WSN. It is required to establish more
specific measurements of node density and sensor range that impact the overall system performance
especially in the intrusion detection application. To enhance the quality of intrusion detection, several
probabilistic models are adopted for heterogeneous WSN in the random deployment scenario.

Methods:
Multi-intrusion detection model probability in a heterogeneous wireless sensor network for
random deployment was used.

Results and Discussion:
In both homogeneous and heterogeneous WSNs, we analyzed our probabilistic
model for multi-intrusion detection in single and multi-sensing detection.

Conclusion:
Our probabilistic models are useful in selecting the critical parameters of WSN in order
to meet the detection quality requirement.
A Novel Construction Method of (OP) Polynomial and Rational Fuzzy
Implications
Authors: Papadopoulos Basil K. , N. Rapti Maria 
Published: June 2022

Abstract:
In this article, we develop new constructed methods with specific conditions. The first
method is a generalization of convex combination using n fuzzy implications. The second method
is a parameterization of Lukasiewicz implication in an Ordering Property (OP) fuzzy implication
form. The innovation in this work is the presentation of three new constructed methods of (OP)
polynomial and (OP) rational fuzzy implications. We investigate some families of Ordering Property (OP) and Ordering Property (OP) Rational fuzzy implications. To these methods, we give
some coefficient conditions in order to satisfy basic properties like ordering property (OP), identity
property (IP) and contrapositive symmetry (CP).

Background:
Fuzzy implication functions are one of the main operations in fuzzy logic. They generalize the classical implication, which takes values in the set {0, 1}, to fuzzy logic, where the truth
values belong to the unit interval [0, 1]. The study of this class of operations has been extensively
developed in the literature in the last 30 years from both theoretical and applicational points of
view.

Introduction:
In this paper, we develop five new methods for constructing fuzzy implications with
specific properties. The paper starts by presenting the first fuzzy implication construction machine
that uses n fuzzy implications with specific conditions. Next, we parameterize Lukasiewicz implication and create new families of (OP) polynomial and (OP) rational implications. For each method
we investigate which conditions are satisfied and we give some examples.

Methods:
The first constructed method uses n fuzzy implications in a linear product representation.
The second method is an (OP) polynomial implication a parameterized Lukasiewicz implication.
The third method is a rational implication with five parameters. In the fourth method we give a
general form in the previous method by changing variables x and y with increasing functions. Finally, the last method is another (OP) rational implication with three parameters.

Results:
In each method we present the properties that are satisfied. We generalize the (OP) polynomial and rational by replacing the variables with monotonic functions or add powers on them.
Finally, we generalize and we give examples of new produced fuzzy implications.

Conclusion:
As a future work, we can create new families of rational implications by changing the
polynomials of the numerator and denominator so that they satisfy more properties. Finally, the
new methods we presented can contribute in the construction of uninorms and copulas under certain conditions.