bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of early lumbar cistern drainage of cerebrospinal fluid and combination of edaravone and nimodipine on vasospasm, intracranial pressure, inflammatory factors in traumatic subarachnoid hemorrhage
Authors: Tong Wenjie , Jiang Yongliang , Huang Bo , Fang Jun 
Published: September 2022

Purpose: To investigate the effect of early lumbar cistern drainage (LCD) of cerebrospinal fluid (CSF) and combination of edaravone and nimodipine on vasospasm, intracranial pressure (ICP), serum inflammation, S100 and vascular endothelial growth factor (VEGF) levels in traumatic subarachnoid hemorrhage (tSAH).
Methods: Treatment was administered to 136 patients divided into control group (n = 68) and study group (n = 68). Serum inflammation was determined by assessing the levels of tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) while nitric oxide (NO), endothelin-1 (ET-1), S100 and VEGF levels were determined by enzyme-linked immunosorbent assay (ELISA). Serum C-reactive protein (CRP) level was measured by immunoturbidimetry. Perfusion weighted imaging was performed and the mean transit time (MTT), cerebral blood flow (CBF), cerebral blood volume (CBV), mean flow velocity (Vm) and pulsatility index (PI) were recorded. Glasgow coma scale (GCS) score and Montreal cognitive assessment (MoCA) score were used to compare the differences in therapeutic effect.
Results: Compared with values before treatment, Vm, PI, NO, CBF, CBV, GCS score and MoCA score were significantly increased (p < 0.05), while ICP, serum levels of TNF-α, IL-6, CRP, ET-1, S100 and VEGF and MTT significantly decreased (p < 0.05). Therapeutic response rate of the study group (89.71 %) was higher than that of control group (66.18%) (p < 0.05).
Conclusion: Early LCD of CSF and combination of edaravone and nimodipine reduces the degree of cerebral vasospasm and contribute to brain function recovery in the treatment of patients with tSAH. This therapeutic strategy requires further clinical trials before application in clinical practice.
Comparison of gemcitabine/carboplat in versus paclitaxel/cisplatin for the management of non small cell lung cancer
Authors: Wang Wei , Li Wenli , Dai Lili , Zhao Lei , Qu Kaixin 
Published: September 2022

Purpose: To determine the comparative efficacy and toxicity of gemcitabine/carboplatin and paclitaxel/cisplatin in patients with completely resected stage IIa - IIIa non-small cell lung cancer (NSCLC).
Methods: Sixty eligible NSCLC patients treated in Funan County People's Hospital were enrolled and assigned to two groups by randomization (n = 30 each). One group (CG group) received the combination of gemcitabine and carboplatin, while the second group (CP group) received a combination of cisplatin and paclitaxel. Efficacy was assessed based on 2-year progression-free survival, while adverse reactions were recorded to assess the toxicity of the chemotherapy treatments.
Results: No marked difference was found in the 2-year relapse-free survival in the two groups with similar clinical baseline characteristics after follow-up (60 % in CG group vs. 56.67 % in CP group, p = 0.826). Specifically, no significant difference was found between the two groups with regard to incidence of local metastases, distant metastases, or brain tissue metastases within 2 years, and there were no treatment-related deaths. CG group was more likely to develop leukopenia (93.33 % vs. 63.33 % for CP group, p = 0.04), but no significant difference was observed for other adverse effects such as anemia, vomiting, and nausea.
Conclusion: This study shows that adjuvant treatment using carboplatin and gemcitabine produces the same therapeutic efficacy as cisplatin and paclitaxel, but exhibits higher toxicity levels than the latter.
Clinical efficacy of combined use of Xuebijing and mild hypothermia therapy for the treatment of severe traumatic brain injury, and its effect on patient mortality and complications
Authors: Zheng Yadong , Chen Peng , Zhang Qingtao , Sun Chao , Xiang Yi , Zhou Weiduo , Xu Yi 
Published: September 2022

Purpose: To investigate the clinical efficacy of combined use of Xuebijing and mild hypothermia therapy in severe traumatic brain injury (TBI), and its effect on mortality and incidence of complications.
Methods: Eighty-six severe TBI patients admitted to The Fourth People's Hospital of Chongqing were selected. Patients were randomly and equally assigned to control group (COG) who received conventional treatment, and study group (EXG) given a combination of Xuebijing and mild hypothermia therapy. Relevant clinical indicators and therapeutic effects were compared.
Results: Post-treatment levels of inflammatory indices, including procalcitonin (PCT), tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) were significantly reduced, with lower levels in EXG (p < 0.05). Between-group differences were seen in human leukocyte antigen-DR isotype (HLA-DR), CD3+, CD4+, CD8+, and C3 indicators (p < 0.05). EXG had significantly lower protein expression levels of neuron-specific enolase (NSE) and S100 beta than COG (p < 0.05). After treatment, plasma protein levels of coagulation indices, viz, prothrombin time (PT) and activated partial thromboplastin time (APTT) were lower than pre-treatment levels, with even much lower levels in EXG (p < 0.05). There were reduced incidence of lung infection, acute gastrointestinal injury, acute respiratory distress syndrome (ARDS) and hypernatremia (p < 0.05). More patients had better recovery in EXG (p < 0.05) than in control group.
Conclusion: The combined therapy improves the prognosis of severe TBI, lowers the levels of inflammatory factors, ameliorates plasma coagulation, and enhances immunity with a high degree of safety. However, further clinical trials should be undertaken prior to application in clinical practice
FMNL1 promotes growth and metastasis of breast cancer by inhibiting BRCA1 via upregulation of HMGA1
Authors: Zhang Qian , Yang Hua , Tang Caiyi , Wang Qian , Ren Lili , Jia Chao , Zou Hui 
Published: September 2022

In the earlier published article, “Herbei Province” included in the affiliation of the second author is incorrect. “Chongqing” is a municipality directly under the Central Government and does not belong to "Hebei Province”. At the request of the author, the correct affiliation is provided above. New citation: Zhang Q, Yang H, Tang C, Wang Q, Ren L, Jia C, et al. FMNL1 promotes growth and metastasis of breast cancer by inhibiting BRCA1 via upregulation of HMGA1. Trop J Pharm Res 2021; 20(8):1559-1564 doi: 10.4314/tjpr.v20i8.2. Erratum: 2022; 21(8): 1807 doi: 10.4314/ tjpr.v 21i8.31
Earlier citation: Zhang Q, Yang H, Tang C, Wang Q, Ren L, Jia C, et al. FMNL1 promotes growth and metastasis of breast cancer by inhibiting BRCA1 via upregulation of HMGA1. Trop J Pharm Res 2021; 20(8):1559-1564 doi: 10.4314/tjpr.v20i8.2
Regulation of RhoA/ROCK1 signaling pathway by miR 26b in sepsis induced acute lung injury
Authors: Mao Yi , Gao Yi , Zhao Zhiwei , Zhang Jinbo , Dong Meiping , Cao Liexiang 
Published: September 2022

Purpose: To investigate the role of miR-26b in the regulation of RhoA/ ROCK1 signaling pathway in acute lung injury (ALI) caused by sepsis.
Methods: Thirty male rats were randomized into sham group (SG), cecal ligation and puncture (CLP) group (CG) and miR-26b mimic group (MG). Hematoxylin and eosin (H & E) staining assay was performed to determine the pathological characteristics of rat lung tissues in each group, while enzyme-linked immunosorbent assay (ELISA) was conducted to determine TNF-α and IL-1β levels. The miR-26b expression was evaluated by quantitative reverse transcription polymerase chain reaction (qRT-PCR), while RhoA and Rock1 protein levels were assessed using western blotting.
Results: The CG had significant lung injury in comparison with the SG. There were significant elevation in TNF-α and IL-1β levels (p < 0.05). RhoA and ROCK1 levels in lung tissue were noticeably elevated in CG (p < 0.05). After treatment, lung injury in MG was reduced in contrast to CG. The MG showed statistically significant decrease (p < 0.05) in the levels of TNF-α and IL-1β, while the lung tissue mRNA expression and the RhoA and ROCK1 expression levels were significantly reduced in MG (p < 0.05).
Conclusion: The MiR-26b mimics plays an important role in the treatment of ALI induced by sepsis in rats by regulating RhoA/ROCK1 signaling pathway. Thus, the findings of this study provide a theoretical basis for clinical studies on the use of miR-26b in the therapy of sepsis.
Annexin A1 mimetic peptide Ac2 26 alleviates renal inflammatory injury in diabetic mouse model by suppressing p38MAPK/NF κB
Authors: Zhang Kangyi , Teng Xiaochun 
Published: September 2022

Purpose: To investigate the protective role of mimetic peptide Ac2-26 of annexin A1 (ANXA1) in regulating p38MAPK/NF-κB for renal inflammatory injury in a diabetic mouse model.
Methods: The mice were divided into three groups (control, model and Ac2-26; n = 8). Control was untreated, normal mice, while Ac2-26 was treated with mimetic peptide Ac2-26 after induction of type I diabetes with streptozotocin (60 mg/kg). The model group was not further treated after induction of diabetes. The fasting blood glucose (FBG), blood lipid, and renal function were evaluated. Serum inflammatory factors in renal tissue were also assessed.
Results: Compared with the model group, there was a significant decrease in the levels of FBG, blood lipids (TG, TC, LDL and ox-LDL), KI, 24 h urinary protein, Cr and BUN, and significant increase in body weight in AC2-26 group (p < 0.001). There was a marked decrease in TNF-α, IL-6, IL-1β, and IL-18 levels, as well as levels of mRNA and protein expressions of p38MAPK, NF-κBP6 and ANXA1 in AC2-26 group when compared with the model group (p < 0.001).
Conclusion: ANXA1 is the target gene of p38MAPK, and mimetic peptide Ac2-26 alleviates renal inflammation by suppressing p38MAPK/NF-κB pathway, thus improving renal function in diabetic mice models. This finding suggests a probable approach to developing an effective treatment for renal inflammation in diabetic renal injury.
Decision Support System for Scoring In Informatics Engineering Practicum Assistant With Simple Additive Weighting (Saw) Method Web 2.0 Based
Authors: Hasibuan Liyando Hermawan , Munaji Achmad Arif , Deolika Agatha , Chitayae Nadya , Setiawan Erik 
Published: September 2022

Abstract— In this modern era, the assessment of an individual with other individuals is still in the subjective stage, a human being assesses the abilities of other humans by using various points of view. Likewise, what Pratikan did to his Pratikum Assistants gave them an assessment that was in accordance with what they had, but the assessment sometimes had different parameters so that the conclusions between one person and another were different, there was no similarity in judging one person.
With the Simple Additive Weighting (SAW) method, the problem can be solved with the help of this method. Websites that have become part of social life and are closely integrated in daily activities. So using the SAW method, one of the alternatives in the assessment can provide a Pratikum Assistant.
The results obtained from these values ​​can provide a new perspective on various kinds of problems. Deciding that no Practicum Assistant can be reused or the results of a given Assessor can help create a new resolution to the pattern of scoring in Practicum Assistants.
Detection of Color Domination of Image Pieces as a Digital Puzzle Machine
Authors: Himamunanto Agustinus Rudatyo , Haeni B Haeni B 
Published: September 2022

Puzzle adalah permainan menata kembali kepingan obyek gambar, yang dapat melatih kreativitas, keteraturan, dan tingkat konsentrasi. Permasalahan dalam permainan puzzle akan semakin rumit saat ukuran kepingan semakin kecil sehingga jumlah kepingan semakin banyak. Tantangannya adalah, bagaimana selalu dapat membuat susunan puzzle baru dan menyusun ulang pemulihan potongan secara cepat. Fokus dalam penelitian ini adalah mengatur potongan puzzle secara random dan berupaya melakukan reposisi puzzle menggunakan metode usulan yaitu DCD (Dominan Color Detection). Metode DCD bekerja dengan menggunakan metode color histogram utuk melakukan pelacakan citra berdasarkan informasi dominan warnanya. Metode Eucledian Distance selanjutnya dipergunakan untuk mengukur tingkat kemiripan citra . Indikasi kemiripan citra puzzle digunakan untuk melakukan reposisi puzzle. Berdasarkan hasil pengujian diketahui bahwa akurasi ketepatan hasil reposisi pada sample citra logo, berjumlah 30 citra uji, adalah 100% berhasil memperoleh utuh kembali sesuai citra input logo. Metode ini berpeluang dipergunakan sebagai alternatif pengamanan akses dan juga sebagai model mesin sederhana pada pencarian gambar berbasis potongan gambar.
El CNB del nivel Preprimario: problemas, fortalezas y debilidades
Authors: Paiz Paz Mindy Gabriela 
Published: September 2022

OBJETIVO: identificar la problemática que enfrenta la aplicación del CNB en el nivel Preprimario, sus fortalezas y debilidades para poder aportar soluciones ya que se constituye como una herramienta valiosa en la problemática educativa del país. MÉTODO: se utilizó el método investigativo y hermenéutico tomando en consideración opiniones y puntos de vista de pedagogos y personas vinculadas al tema. RESULTADOS: como producto de la escasa inversión pública en educación se demuestra que la mayor parte de maestras del nivel Preprimario no han recibido la inducción pertinente ni el apoyo en materiales e insumos que deberían tener para poder realizar exitosamente su labor. CONCLUSIÓN: el CNB del nivel Preprimario se constituye en una herramienta valiosa que vino a constituirse como un elemento innovador de la educación de los niños y niñas de la segunda infancia y que tiene como competencias el prepararlos con valores, juicio crítico y aprestamiento eficaz para enfrentarse a los desafíos del nivel Primario.
Ambientes familiares y aprendizaje durante la pandemia del COVID -19
Authors: Pineda Escobar Elvia Amarilis 
Published: September 2022

OBJETIVO: describir cómo son los espacios de los ambientes familiares de los estudiantes en la educación virtual y su relación con el aprendizaje, según la percepción de los educandos. MÉTODO: se trabajó desde un enfoque mixto, diseño de triangulación concurrente y alcance descriptivo y explicativo. La muestra se eligió de manera intencionada por conveniencia quedando determinada por la participación voluntaria, y quedó constituida por 23 estudiantes del INEB Telesecundaria Ciudad Peronia y 18 estudiantes del INEB Telesecundaria El Calvario, además de nueve madres y un padre de familia. RESULTADOS: los padres de familia revelan en la entrevista, que los espacios que ocupan sus hijos para recibir clases virtuales durante la pandemia COVID- 19, varían, unos tienen buena iluminación y son amplios y cómodos, pero la mayoría son pequeños, en ocasiones no tiene un lugar fijo, trabajan algunas veces en la recámara e incluso afuera de la casa, en general las familias son de escasos recursos. CONCLUSIÓN: los estudiantes y padres de familia de los centros educativos de Telesecundaria Ciudad Peronia y El Calvario, afirman que reciben clases en la sala o en sus habitaciones, los ambientes familiares se vuelven salones de clases con condiciones no aptas para el aprendizaje.
Las estrategias innovadoras y el aprendizaje significativo
Authors: Fuentes Martínez Iraida Lisseth 
Published: September 2022

OBJETIVO: determinar las estrategias innovadoras que han aplicado los docentes para el logro de un aprendizaje significativo. MÉTODO: enfoque mixto. El tipo de muestra es no probabilístico, se realizó un muestreo denominado censo, porque toda la población fue seleccionada para este estudio, con un total de 48 profesores, de los cuales 46 respondieron y 2 se abstuvieron. RESULTADOS: se reveló que los profesores en su mayoría manifiestan que periódicamente utilizan estrategias innovadoras en la modalidad híbrida y las actividades sincrónicas las usan para el logro de un aprendizaje significativo en las sesiones de aprendizaje, utilizan la clase invertida, evidenciando las opciones que nos brinda esta es la más adecuada para ellos. La herramienta que más utilizan los profesores con sus estudiantes es la plataforma Moddle. CONCLUSIÓN: las estrategias innovadoras que más aplican en su acción educativa, en la modalidad asincrónica es la plataforma Moddle, tales como el portafolio, el foro, el correo y la web educativa; en la modalidad sincrónica se utilizó para las conversaciones en forma oral o escrita, Zoom, por medio de las videoconferencias, el WhatsApp, para mantener fluida la comunicación asertiva con sus estudiantes, en su acción educativa en su orden de selección eligió la opción múltiple u otros y las herramientas de organizadores gráficos le fueron de mucha utilidad para el aprendizaje significativo.
Uma análise do home office e dos seus impactos causados no âmbito do conflito trabalho-família
Authors: Santos Darlim Yasmim Souza dos , Almeida Damiana Machado de , Menegazzi Raquel Boff 
Published: September 2022

O presente estudo buscou analisar o trabalho no home office e os seus impactos causados no âmbito do conflito trabalho-família. Nesta senda, com a inserção da COVID-19, as organizações implementaram trabalho remoto e os colaboradores começaram a trabalhar em home office, desencadeando consequências causadas no âmbito trabalho-família. Esse estudo se caracteriza como descritivo com abordagem quantitativa, compondo uma amostra de 49 respondentes. Quanto ao procedimento técnico, foi aplicado o levantamento de dados por meio de uma survey. Para a coleta de dados, utilizou-se a escala conflito trabalho-família validada por Bastos et al. (2014). Foi possível perceber os impactos do home office no âmbito trabalho-família, visto que as demandas do trabalho interferem na vida familiar (x = 4,35), bem como as demandas da família interferem nas atividades de trabalho (x = 3,16). Os respondentes afirmaram que os maiores desafios enfrentados foram não ter acesso às ferramentas ou informações necessárias para realizar o trabalho (n = 15) e manter uma rotina de trabalho regular (n = 24). Quanto à satisfação no trabalho, em relação às condições, 38,77% dos respondentes afirmaram que se o home office continuar por mais tempo as organizações terão que tomar medidas cabíveis para aprimorar essa forma de trabalho. Sugere-se para pesquisas futuras, a realização de estudos com abordagem mista, com o público multifacetado e com a inserção de outras características de perfil.

ABSTRACT
This study sought to analyze the home office and its impacts caused in the context of work-family conflict. In this path, with the insertion of COVID-19, organizations implemented remote work and employees began to work from home offices, triggering consequences in the work-family scope. This study is characterized as descriptive with a quantitative approach, comprising a sample of 49 respondents. As for the technical procedure, data collection was applied through a survey. For data collection, the work-family conflict scale validated by Bastos et al. (2014) was used. It was possible to perceive the impacts of the home office in the work-family context, as the demands of work interfere in family life (x = 4.35), as well as the demands of the family interfere in work activities (x = 3.16). Respondents stated that the biggest challenges they faced were not having access to the tools or information necessary to carry out the work (n = 15) and maintaining a regular work routine (n = 24). As for job satisfaction, in relation to conditions, 38.77% of respondents said that if the home office continues for longer, it is necessary to take appropriate measures to improve this way of working. The sample studied is a limitation of this study, so it is suggested for future research to carry out studies with a mixed approach, with a multifaceted public and with the inclusion of other profile characteristics.
Development of technology for obtaining protein hydrolysate from offal of category II
Authors: Tokysheva G. M. , Kakimov M. M. , Tultabayeva T. Ch. , Mashanova N. S. , Makangali K. K. 
Published: September 2022

The object of research chosen in the work is low-value products of slaughter and processing of livestock, in particular by-products of category II. Having a sufficient protein content and a number of other properties necessary for the production of protein hydrolysates. At the same time, the use of such secondary products seems promising, since in this case, on the one hand, prerequisites are created for the creation of low-waste technologies, and on the other hand, it becomes possible to produce combined products with an optimal ratio of nutrients. The research results show a high content of glycine, alanine, glutamic acid, serine, and proline in wool by-products, i. e. those amino acids that are mainly contained in collagen. Collagen hydrolysate was obtained by enzymatic hydrolysis of legs with a put joint. Taking into account the peculiarities of the preparation of the components, the technological process was worked out and a technological scheme for obtaining protein hydrolysate was proposed.
PENTINGNYA KUALITAS KOMUNIKASI PERAWAT DAN DOKTER SEBAGAI UPAYA PENINGKATAN KEPUASAN PASIEN DI RUMAH SAKIT
Authors: Paramitha Dewi Setya , Kirana Rita , Akbar Muhaimin MPR Andrey Rizky 
Published: September 2022

The collaboration practice in health services most often in hospitals is hospital team between nurses and doctors. Barriers that make collaboration not maximized due to lack of communication between them. The purpose of this study was to determine the relationship between the communication quality of nurses and doctors with patient satisfaction. The research method used a quantitative analytic design with a Cross Sectional approach. The number of research samples is 77 patients in the inpatient ward. The sampling technique used Accidental Sampling. Data analysis used Spearman Rank statistical test. The results showed that the communication quality of nurses and doctors in the very good category was 98.7%, patient satisfaction was in the very satisfied category 94.8% and there was a relationship between the communication quality of nurses and doctors with patient satisfaction, the value (p = 0.000 < 0.05) with correlation coefficient 0.490 moderate relationship. The results show that collaborative practice between nurses and doctors must be maintained and interprofessional collaboration education is an effective strategy to build collaboration since health education between nurses and doctors.
Keywords: doctors, communication, nurses, patient satisfaction