bluuebunny/crossref_metadata_2025_split huggingface dataset:
Lignans: a versatile source of anticancer drugs
Authors: Mukhija Minky , Joshi Bhuwan Chandra , Bairy Partha Sarathi , Bhargava Anurag , Sah Archana N. 
Published: June 2022

Abstract
Background
Cancer is considered as the second deadliest disease globally. Plants have continuously offered unique secondary metabolites with remarkable biological applications. Lignans have gained great importance due to their biological activity. Previous studies revealed that the most remarkable bioactivity of lignan class of molecules is anticancer. They are derived from the oxidative dimerization of two phenylpropanoid units. This review covers the isolated anticancer lignans and their mechanistic aspects.

Main body
A bibliographic investigation was performed by analyzing the information available on anticancer lignans in the internationally accepted scientific databases including Web of Science, SciFinder, PubMed, Scopus, and Google Scholar. In this review we have tried to sum up the isolated anticancerous lignan, its source, active plant part, extract and various cell lines used to establish different studies. Here we have included a total number of 113 natural lignans. Many studies that mainly performed in human cell lines have reported. Very few plants have been evaluated for their in vivo anticancer activity.

Conclusion
It can be concluded that in near future the lignans may be an effective pharmacon for the treatment of cancer. Fruitful areas of future research may be in modifying natural lignans or synthesizing new lignans with structural diversity and potent pharmacological activities. Extensive studies are needed to be done highlighting the mechanism of anticancer action of explored and unexplored plants. The data will definitely attract many researchers to start further experimentation that might lead to the drugs for the cancer treatment.

Graphical Abstract
Surgeon-performed ultrasound-guided head and neck procedures during COVID-19 pandemic
Authors: Toong Liew Yew , Ghauth Sakina 
Published: June 2022

Abstract
Background
The ultrasonographic procedure is a common diagnostic and therapeutic method in daily medical practice. Surgeon-performed ultrasound (SUS) has been gaining popularity, especially during this COVID-19 pandemic.

Methods
Two ENT surgeons performed US-guided diagnostic or therapeutic procedures in the outpatient clinic. A successful SUS is defined as the diagnostic procedure's ability to facilitate the final histopathological diagnosis that can guide the subsequent treatment and disease resolution following the therapeutic procedure without the need for more invasive open surgical intervention.

Results
Out of 10 participants, 6 are males, and 4 are females. There were no complications noted. All subjects had successful tissue sampling or intervention on the first attempt for diagnostic and therapeutic SUS.

Conclusions
With COVID-19, there has been a significant shift in ordinary medical practice. SUS is proven to be a safe and effective method to facilitate the management of head and neck pathologies.
Study designs and research methodology in the field of otolaryngology
Authors: Zamzam Sameh M. , Abdel-Aziz Mosaad , Atef Ahmed , Abdel-Naseer Usama , Hamoda Mostafa , Salah Mohamed , Dewidar Hazem , Elsharkawy Louay , Fawzy Mahmoud , Shabana Mohamed , Elkhosht Mostafa , Eldesouky Hussan , Hamdy Hussien Sherif 
Published: June 2022

Abstract
Background
Scientific studies require a well-prepared cascade of steps starting from the idea and formulating a research question passing through collecting data and analysis of the results to proper writing a good article and publication. The methodology section is the core of any scientific article.

Main body
Study designs in otolaryngology can be classified as “observational studies,” “experimental (interventional) studies,” and “meta-analysis—systematic review.” There may be a huge range in quality between kinds of studies. To standardize the method of reporting the quality of studies and include all important aspects in the evaluation process, a team of scientists created the reporting guidelines checklists.

Conclusions
In this article, we give a comprehensive review that can help authors to understand study designs in otolaryngology along with the appropriate reporting guidelines used in each study.
Undulating sediments of the Cape Fear submarine landslide system, offshore U.S. Atlantic margin: Sediment waves versus creep deformation
Authors: Fillingham Jacob N. , Sawyer Derek E. , Bécel Anne 
Published: June 2022

We interpret a region of undulatory sediments adjacent to a major headwall of the Cape Fear submarine landslide system offshore of North Carolina, USA, as sediment waves rather than creep or fault-related deformation. The wave package extends 19 km upslope from the S4 landslide headwall and thickens upslope from approximately 250 to 450 m. The field of undulating sediments displays the continuity of seismic horizons, upslope-migrating crests, downslope thinning, and wave heights and lengths of approximately 26 m and approximately 1 km, respectively, which are consistent with sediment wavefields. The Western Boundary Undercurrent formed contourites on the nearby Blake Ridge and it is possible that these sediment undulations were deposited via similar mechanisms. Ocean Drilling Program (ODP) cores near the sediment undulation field suggest that the turbidity currents also may have played a role in wave formation. Although most of the 19 km long field comprises unaltered sediment waves, we observe an approximately 5 km long zone adjacent to the landslide scarp that expresses evidence of faults that offset and deform the sediment wave strata. We interpret this deformation as the result of reduction in stress following the removal of the landslide mass. Given that the Cape Fear system has generated several episodes of potentially tsunamigenic slope failure, the future stability of the system is pertinent. Redefining these undulatory sediments as sediment waves eliminates a major slope instability mechanism of the system and is important for understanding the future slope stability hazards of Cape Fear. Our analysis highlights the importance of understanding sediment waves in hybrid submarine landslide-sediment wave systems. Geological feature: Cape Fear submarine landslide sediment waves Seismic appearance: Continuous undulating horizons Alternative interpretations: Downslope creep or faults Features with similar appearance: Extensional slope failure Formation: Alongslope and downslope currents Age: Quaternary Location: Cape Fear submarine landslide complex, offshore North Carolina Seismic data: High resolution multichannel seismic data Analysis tools: Multichannel seismic data, multibeam bathymetry, sub-bottom Chirp
Training General Practitioners in Oncology: A Needs Assessment Survey From Nepal
Authors: Gyawali Bishal , Thapa Niresh , Savage Colleen , Carson Laura M. , Jalink Matthew , Rawal Mangal , Berry Scott , Sharma Poudyal Bishesh 
Published: June 2022

PURPOSE Nepal lacks enough cancer care providers to address the growing burden of cancer in the country. One way of addressing this issue is to train general practitioners (GPs) in oncology (GPOs) so that they can task-share and task-shift oncology care. However, limited information is available regarding the current level of oncology expertise of Nepali GPs and whether they perceive a need for, and have an interest in, such a GPO training program if available in Nepal. METHODS A survey was distributed to GPs in Nepal to collect data on current oncology training and clinical practice and evaluate levels of interest and need for a GPO training program. The survey was distributed electronically from February to July 2021. RESULTS The survey obtained 71 individual responses from GPs in Nepal. The majority of respondents were male (87%), and most worked as consultants or senior consultants (63%). Only 6% of respondents had a mandatory oncology rotation during their GP training, and only 15% indicated that their GP training had adequately prepared them to care for patients with cancer. Ninety-six percent of respondents perceived a need for a GPO training program in Nepal, with 94% indicating an interest in enrolling in such a program and 71% indicating that they were very interested. CONCLUSION The findings indicate an urgent need for and an encouraging interest in establishing a GPO training program in Nepal. These findings will be used to guide the development and implementation of this type of program.
Three-Year Follow-Up of KTE-X19 in Patients With Relapsed/Refractory Mantle Cell Lymphoma, Including High-Risk Subgroups, in the ZUMA-2 Study
Authors: Wang Michael , Munoz Javier , Goy Andre , Locke Frederick L. , Jacobson Caron A. , Hill Brian T. , Timmerman John M. , Holmes Houston , Jaglowski Samantha , Flinn Ian W. , McSweeney Peter A. , Miklos David B. , Pagel John M. , Kersten Marie José , Bouabdallah Krimo , Khanal Rashmi , Topp Max S. , Houot Roch , Beitinjaneh Amer , Peng Weimin , Fang Xiang , Shen Rhine R. , Siddiqi Rubina , Kloos Ioana , Reagan Patrick M. 
Published: June 2022

PURPOSE Brexucabtagene autoleucel (KTE-X19) autologous anti-CD19 chimeric antigen receptor (CAR) T-cell therapy is approved for the treatment of relapsed/refractory mantle cell lymphoma (MCL). Outcomes after a 3-year follow-up in the pivotal ZUMA-2 study of KTE-X19 in relapsed/refractory MCL are reported, including for subgroups by prior therapy (bendamustine and type of Bruton tyrosine kinase inhibitor [BTKi]) or high-risk characteristics. METHODS Patients with relapsed/refractory MCL (one to five prior therapies, including prior BTKi exposure) received a single infusion of KTE-X19 (2 × 106 CAR T cells/kg). RESULTS After a median follow-up of 35.6 months, the objective response rate among all 68 treated patients was 91% (95% CI, 81.8 to 96.7) with 68% complete responses (95% CI, 55.2 to 78.5); medians for duration of response, progression-free survival, and overall survival were 28.2 months (95% CI, 13.5 to 47.1), 25.8 months (95% CI, 9.6 to 47.6), and 46.6 months (95% CI, 24.9 to not estimable), respectively. Post hoc analyses showed that objective response rates and ongoing response rates were consistent among prespecified subgroups by prior BTKi exposure or high-risk characteristics. In an exploratory analysis, patients with prior bendamustine benefited from KTE-X19, but showed a trend toward attenuated T-cell functionality, with more impact of bendamustine given within 6 versus 12 months of leukapheresis. Late-onset toxicities were infrequent; only 3% of treatment-emergent adverse events of interest in ZUMA-2 occurred during this longer follow-up period. Translational assessments revealed associations with long-term benefits of KTE-X19 including high-peak CAR T-cell expansion in responders and the predictive value of minimal residual disease for relapse. CONCLUSION These data, representing the longest follow-up of CAR T-cell therapy in patients with MCL to date, suggest that KTE-X19 induced durable long-term responses with manageable safety in patients with relapsed/refractory MCL and may also benefit those with high-risk characteristics.
Ciltacabtagene Autoleucel, an Anti–B-cell Maturation Antigen Chimeric Antigen Receptor T-Cell Therapy, for Relapsed/Refractory Multiple Myeloma: CARTITUDE-1 2-Year Follow-Up
Authors: Martin Thomas , Usmani Saad Z. , Berdeja Jesus G. , Agha Mounzer , Cohen Adam D. , Hari Parameswaran , Avigan David , Deol Abhinav , Htut Myo , Lesokhin Alexander , Munshi Nikhil C. , O'Donnell Elizabeth , Stewart A. Keith , Schecter Jordan M. , Goldberg Jenna D. , Jackson Carolyn C. , Yeh Tzu-Min , Banerjee Arnob , Allred Alicia , Zudaire Enrique , Deraedt William , Olyslager Yunsi , Zhou Changwei , Pacaud Lida , Madduri Deepu , Jakubowiak Andrzej , Lin Yi , Jagannath Sundar 
Published: June 2022

PURPOSE CARTITUDE-1, a phase Ib/II study evaluating the safety and efficacy of ciltacabtagene autoleucel (cilta-cel) in heavily pretreated patients with relapsed/refractory multiple myeloma, yielded early, deep, and durable responses at 12 months. Here, we present updated results 2 years after last patient in (median follow-up [MFU] approximately 28 months), including analyses of high-risk patient subgroups. METHODS Eligible patients had relapsed/refractory multiple myeloma, had received ≥ 3 prior lines of therapy or were double refractory to a proteasome inhibitor and immunomodulatory drug and had received prior proteasome inhibitor, immunomodulatory drug, and anti-CD38 therapy. Patients received a single cilta-cel infusion 5-7 days after lymphodepletion. Responses were assessed by an independent review committee. RESULTS At a MFU of 27.7 months (N = 97), the overall response rate was 97.9% (95% CI, 92.7 to 99.7); 82.5% (95% CI, 73.4 to 89.4) of patients achieved a stringent complete response. Median duration of response was not estimable. Median progression-free survival (PFS) and overall survival (OS) were not reached; 27-month PFS and OS rates were 54.9% (95% CI, 44.0 to 64.6) and 70.4% (95% CI, 60.1 to 78.6), respectively. Overall response rates were high across all subgroups (95.1%-100%). Duration of response, PFS, and/or OS were shorter in patients with high-risk cytogenetics, International Staging System stage III, high tumor burden, or plasmacytomas. The safety profile was manageable with no new cilta-cel–related cytokine release syndrome and one new case of parkinsonism (day 914 after cilta-cel) since the last report. CONCLUSION At approximately 28 months MFU, patients treated with cilta-cel maintained deep and durable responses, observed in both standard and high-risk subgroups. The risk/benefit profile of cilta-cel remained favorable with longer follow-up.
“Mourners Are the Soundtrack of Life”
Authors: Hagay Re'ee 
Published: June 2022

AbstractThis article describes the mourning interwoven into the process of writing Ahuva ‘Ozeri's biography. The nonlinear temporality of the mourning produced by the child mourner from Tel Aviv's Yemenite Quarter is juxtaposed with national representations of Yemeni Jews, constructed as an origin of Jewish homogeneity rooted in the past. Hagay focuses on ‘Ozeri's cinematic performance against the background of south Tel Aviv, revealing a twofold memory of loss, both Mizrahi and Palestinian. ‘Ozeri emerges as a singer who drew on multiple resources of mourning positioned across putative national and regional borders of urban and global Southern geographies. ‘Ozeri is narrated not only as a child mourner but also as the last mourner, in the face of progressive national time. Hagay concludes by asking what is lost with the last mourner's departure from the world, when one loses the ability to recognize one's own loss through its reflection in the other's ruins.
The Cemetery for theKimsesiz
Authors: Zengin Aslı 
Published: June 2022

AbstractThe Turkish cemeteries for the kimsesiz (literally, people who have no one) are graveyards where the state buries the bodies of those people who remain unidentified or unclaimed after a certain period of time. In practice, they are burial sites for the social outcast, namely homeless and underclass people, victims of honor crimes, disowned members of blood families, premature babies, and more recently, unaccompanied refugees. They also contain the bodies of political detainees who have been “disappeared” under police interrogation and state violence, along with radical leftists and Kurdish guerrillas deemed “unidentified.” This article focuses on the cemetery for the kimsesiz in Kilyos, Istanbul in order to discuss the spatial ordering of death in the margins of social and political life in Turkey. These margins may be ethnic, religious, sectarian, or economic as well as gendered or sexed and sometimes medical. A close focus on this mortal topography of margins demonstrates the state's complicated relationship with the category of kimsesiz and the limits of social legibility and belonging in Turkey.
Effects of the COVID-19 pandemic on the management of ST-Segment elevation myocardial infarction in Indonesia: a cohort study
Authors: Ginanjar Eka , Mansjoer Arif , Rusdi Lusiani , Ramadantie Rizky , Habib Hadiki , Liastuti Lies Dina , Nasution Sally Aman , Alwi Idrus , Rahman Abdul Rashid Abdul 
Published: June 2022

Background: ST-segment elevation myocardial infarction (STEMI) is a form of acute coronary syndrome with high mortality rate. Management of STEMI should be performed as soon as possible to prevent further damage. With the emergence of coronavirus disease 2019 (COVID-19), it may face obstacles. To overcome those problems, some changes in policy focusing on fibrinolytic therapy in STEMI patients have been applied. This study aimed to identify the effects of COVID-19 in management of STEMI patients in Indonesia. Methods: This retrospective study was conducted in Dr. Cipto Mangunkusumo Hospital (CMH), the national referral center in Indonesia. We compared data between 2018 to 2019 and 2020 to 2021 as before and during COVID-19 pandemic period, respectively. We analyzed the effects of COVID-19 on STEMI patients' visits to hospital i.e., monthly hospital admission and symptoms-to-hospital, management of STEMI i.e., the strategies and time of reperfusion, and clinical outcomes of STEMI patients i.e., major adverse coronary event and mortality. Results: There was a significant statistically reduced mean of monthly hospital admissions from 11 to 7 (p = 0.002) and prolonged duration of symptoms-to-hospital during COVID-19 from 8 to 12 hours (p = 0.005). There was also a decrease in primary percutaneous coronary intervention (PPCI) procedures during COVID-19 (65.2% vs. 27.8%, p<0.001), which was accompanied by an increased number of fibrinolytic (1.5% vs. 9.5%, p<0.001) and conservative therapy (28.5% vs. 55.6%, p <0.01). Moreover, there was also a prolonged duration of diagnosis-to-wire-crossing time (160 vs. 186 minutes, p = 0.005), meanwhile, percentage of urgent PCI, door-to-needle time, and clinical outcomes were not statistically significant. Conclusions: During COVID-19 pandemic, the number STEMI patients declined in monthly hospital admission, delays in symptoms-to-hospital time, changes in type of reperfusion strategy, and delays in PPCI procedures in CMH. Meanwhile, fibrinolytic time and clinical outcomes were not affected.
Cost and pollution by the use of xylene in cervical cytology in four Peruvian hospitals
Authors: Moya-Salazar Jeel , Salazar-Hernández Richard , Rojas-Zumaran Victor , Cruz-Gonzales Gloria , Contreras-Pulache Hans 
Published: June 2022

Background: Cytological samples are cleared with xylene in two or three baths during a Pap test, however, this solvent has a high degree of toxicity, and being a controlled reagent infers high costs for its purchase and implications for environmental pollution. We estimated the impact of xylene during the Pap test in terms of the number of liters and cost of two baths of xylene, and also estimated the impact with three baths Methods: This cross-sectional study was carried out in four hospitals of EsSalud in Peru in two stages. First, the analysis of the impact due to the use of two baths of xylene was conducted during the period 2015–2019, and second, the estimates were calculated based on the assumption of three baths of xylene for the years 2020–2025. The assumption was based on the recommendations of the 2018 EsSalud cytology guideline. The monthly amount of xylene was ~10 liters per bath/month and the cost per liter was estimated at 8.13 USD (27 soles). Results: For the staining of 594,898 cytology tests, 7,848 liters of xylene were necessary, resulting in a cost of 60,861 USD (202,068 soles) during the period 2015–2019. The estimates showed a maximum assumption of 9,483 liters and 77,110 USD (256,040 soles) for the use of three baths of xylene in the four EsSalud hospitals (p = 0.0025) during the period 2020–2025. Conclusions: We determined that there was a high economic impact of using xylene with two baths from 2015 to 2019 and a dramatic increase in costs with the possible use of three baths of xylene in the Pap test for the following five years.
O juízo de prelibação na fase homologatória dos acordos de colaboração premiada: controle a partir das balizas fixadas no art. 3º-B, § 4º, da Lei nº 12.850/2013
Authors: Matos Francisco Tojal Dantas , Madera Nunes Mariana , Vasconcellos Vinicius Gomes de 
Published: June 2022

Neste artigo, a partir de revisão bibliográfica, analisa-se o controle judicial na fase homologatória dos acordos de colaboração premiada. Embora a Lei n. 13.964/2019 tenha alterado substancialmente o regramento do instituto, pormenorizando os espaços de atuação do julgador na fase de homologação, notadamente quanto à necessidade de verificação dos aspectos formais da delação – regularidade, legalidade, adequação e voluntariedade –, deixou de prever as balizas para realização do juízo de prelibação dos pactos. Isso acarreta riscos à indispensável vinculação do julgador, no momento do sentenciamento, aos termos do negócio jurídico homologado. Portanto, almeja-se responder ao seguinte problema: quais são os limites do controle judicial sobre o mérito do acordo de colaboração premiada no momento da homologação? Após assentar o conceito de juízo homologatório e os poderes do magistrado em tal momento, sustentar-se-á a tese de que a análise perfunctória dos elementos probatórios perpassa pelo controle acerca da concreta identificação dos fatos, idônea definição das capitulações jurídicas e coerente verificação da relevância, utilidade e interesse público dos acordos, tendo por base os parâmetros legais previstos no artigo 3º-B, § 4º, da Lei n. 12.850/2013. Assim, busca-se alcançar maior segurança jurídica e previsibilidade na utilização do instituto da colaboração premiada no sistema de justiça criminal negocial pátrio.
Self-rated health in Swedish pregnant women: a comprehensive population register study
Authors: Khalaf Atika , Johansson Marianne , Ghani Rania Mahmoud Abdel , Ny Pernilla 
Published: June 2022

Background/Aims Sociodemographic factors are associated with perceived overall health status or ‘self-rated health’. However, research using data from the comprehensive population register in Sweden to examine self-rated health in pregnant women is limited. This study aimed to examine sociodemographic factors associated with self-rated health before, during and after pregnancy in low-risk pregnant women, based on comprehensive population register data in Sweden. Methods This was a retrospective analysis of the Swedish pregnancy register (Graviditets registret). Data from 167 523 women were tested with group comparisons and ordinal regression analyses. Results Women between the ages of 25 and 29 years and primiparas were less likely to self-rate their health lower. Women born outside Scandinavia, those whose education did not reach university level, jobseekers, those on parental leave and students were more likely to report lower self-rated health. Women with risky behaviours, such as alcohol consumption and those who smoked and/or snuffed were more likely to report lower self-rated health. Conclusions The findings indicate that preventive and health promoting actions in the midwifery profession should build on awareness of possible associated sociodemographic factors.