bluuebunny/crossref_metadata_2025_split huggingface dataset:
Targeted Interleukin‐9 delivery in pulmonary hypertension: Comparison of immunocytokine formats and effector cell study
Authors: Heiss Judith , Grün Katja , Tempel Laura , Matasci Mattia , Schrepper Andrea , Schwarzer Michael , Bauer Reinhard , Förster Martin , Berndt Alexander , Jung Christian , Schulze P. Christian , Neri Dario , Franz Marcus 
Published: November 2022

AbstractAimsPulmonary hypertension (PH) is accompanied by pulmonary vascular remodelling. By targeted delivery of Interleukin‐9 (IL9) via the immunocytokine F8IL9, beneficial effects could be demonstrated in a mouse model of PH. This study aimed to compare two immunocytokine formats (single‐chain Fv and full IgG) and to identify potential target cells of IL9.MethodsThe Monocrotaline mouse model of PH (PH, n = 12) was chosen to evaluate the treatment effects of F8IL9F8 (n = 12) and F8IgGIL9 (n = 6) compared with sham‐induced animals (control, n = 10), the dual endothelin receptor antagonist Macitentan (MAC, n = 12) or IL9‐based immunocytokines with irrelevant antigen specificity (KSFIL9KSF, n = 12; KSFIgGIL9 n = 6). Besides comparative validation of treatment effects, the study was focused on the detection and quantification of mast cells (MCs) and regulatory T cells (Tregs).ResultsThere was a significantly elevated systolic right ventricular pressure (104 ± 36 vs. 45 ± 17 mmHg) and an impairment of right ventricular echocardiographic parameters (RVbasal: 2.52 ± 0.25 vs. 1.94 ± 0.13 mm) in untreated PH compared with controls (p < 0.05). Only the groups treated with F8IL9, irrespective of the format, showed consistent beneficial effects (p < 0.05). Moreover, F8IL9F8 but not F8IgGIL9 treatment significantly reduced lung tissue damage compared with untreated PH mice (p < 0.05). There was a significant increase in Tregs in F8IL9‐treated compared with control animals, the untreated PH and the MAC group (p < 0.05).ConclusionsBeneficial treatment effects of targeted IL9 delivery in a preclinical model of PH could be convincingly validated. IL9‐mediated recruitment of Tregs into lung tissue might play a crucial role in the induction of anti‐inflammatory and anti‐proliferative mechanisms potentially contributing to a novel disease‐modifying concept.
Conservative management of a lymphocele that formed shortly after creation of an arteriovenous fistula for hemodialysis
Authors: Zhou Meixia , Behera Tapas Ranjan , Xu Beilei , Shen Quanquan 
Published: November 2022

AbstractPatients with end‐stage renal disease require to establish vascular access for regular hemodialysis. The creation of arteriovenous fistula (AVF) is usually a safe procedure; however, there could be complications such as bleeding, hematoma, pseudoaneurysm, thrombosis, infection, and steal syndrome. A rare complication of such vascular manipulation could be formation of lymphocele. We present a case of a 67‐year‐old man who presented with a progressively enlarging mass 12 days after the surgery for AVF creation at the site of surgery in the right upper arm. Ultrasonographic examination revealed a fluid‐filled cystic structure measuring about 4.2 × 3.6 × 1.9 cm under the skin just above the anastomosis. The fluid was aspirated using ultrasound‐guided fluoroscopy that relieved the swelling. The analysis of aspirate suggested the cyst to be a lymphocele. The mass re‐enlarged to its previous size in the next 3 days. While under observation for signs of complication, regular intermittent compression and a low‐fat diet completely resolved the lymphocele over the subsequent 3 months. The less common occurrence of such lymphocele post AVF creation needs to be evaluated for its potential for complication, in the absence of which the lymphocele is amenable to conservative management using regular intermittent compression and low‐fat oral diet.
Meta‐analysis of the diagnostic accuracy of serum type IV collagen 7S concentration for the staging of liver fibrosis in nonalcoholic fatty liver disease
Authors: Honda Yasushi , Yoneda Masato , Kobayashi Takashi , Iwaki Michihiro , Kawamura Nobuyoshi , Nogami Asako , Kessoku Takaomi , Ogawa Yuji , Tomeno Wataru , Imajo Kento , Horita Nobuyuki , Saito Satoru , Kaneko Takeshi , Nakajima Atsushi 
Published: November 2022

AbstractAimWe aimed to evaluate the diagnostic accuracy of the measurement of serum type IV collagen 7S (T4C7S) concentration for the staging of liver fibrosis in patients with nonalcoholic fatty liver disease (NAFLD).MethodsA systematic search or published works was carried out using the PubMed, Cochrane Library, and Web of Science Core Collection databases for studies of the accuracy of serum T4C7S concentration for the staging of fibrosis using Fibrosis stage (F)0–4 in patients with NAFLD diagnosed by liver biopsy.ResultsNine articles describing 1475 participants with NAFLD were included. For fibrosis ≥F1, with n = 849, summary estimates of sensitivity of 0.79, specificity of 0.69, and area under the curve (AUC) of 0.80 were obtained using a median T7C4S cut‐off value of 4.6 ng/ml. For fibrosis ≥F2, with n = 1,090, summary estimates of sensitivity of 0.78, specificity of 0.78, and AUC of 0.84 were obtained using a median cut‐off value of 4.9 ng/ml. For fibrosis ≥F3, with n = 1311 participants and a median cut‐off value of 5.4 ng/ml, a pooled sensitivity of 0.82, specificity of 0.81, and AUC of 0.83 were obtained. For fibrosis ≥F4, with n = 753 and a median cut‐off value of 6.6 ng/ml, a pooled sensitivity of 0.85, specificity of 0.81, and AUC of 0.85 were obtained.ConclusionsSerum T4C7S concentration was found to be an accurate method of staging liver fibrosis in patients with NAFLD.
Salivary carcinosarcoma: insight into multistep pathogenesis indicates uniform origin as sarcomatoid variant of carcinoma ex pleomorphic adenoma with frequent heterologous elements
Authors: Ihrler Stephan , Stiefel David , Jurmeister Philipp , Sandison Ann , Chaston Nicola , Laco Jan , Zidar Nina , Brcic Luka , Stoehr Robert , Agaimy Abbas 
Published: November 2022

AimsThe formal pathogenesis of salivary carcinosarcoma (SCS) remained unclear, both with respect to the hypothetical development from either preexisting pleomorphic adenoma (PA) or de novo and the clonal relationship between highly heterogeneous carcinomatous and sarcomatous components.Methods and resultsWe performed clinicopathological and molecular (targeted RNA sequencing) analyses on a large series of 16 cases and combined this with a comprehensive literature search (111 cases). Extensive sampling (average 11.6 blocks), combined with immunohistochemistry and molecular studies (PA‐specific translocations including PLAG1 or HMGA2 proven in 6/16 cases), enabled the morphogenetic identification of PA in 15/16 cases (93.8%), by far surpassing a reported rate of 49.6%. Furthermore, we demonstrated a multistep (intraductal/intracapsular/extracapsular) adenoma‐carcinoma‐sarcoma‐progression, based on two alternative histogenetic pathways (intraductal, 56.3%, versus myoepithelial pathway, 37.5%). Thereby, early intracapsular stages are identical to conventional carcinoma ex PA, while later extracapsular stages are dominated by secondary, frequently heterologous sarcomatous transformation with often large tumour size (>60 mm).ConclusionOur findings strongly indicate that SCS (almost) always develops from PA, with a complex multistep adenoma‐carcinoma‐sarcoma‐sequence, based on two alternative histogenetic pathways. The findings from this novel approach strongly suggest that SCS pathogenetically is a rare (3–6%), unique, and aggressive variant of carcinoma ex PA with secondary sarcomatous overgrowth. In analogy to changes of terminology in other organs, the term “sarcomatoid carcinoma ex PA with/without heterologous elements” might be more appropriate.
Associations between HIV stigma and social support for people living with HIV in Hyderabad, India
Authors: Tripathi Saumya , Azhar Sameena 
Published: November 2022

AbstractThe present study examined the association between social support and Human Immunodeficiency Virus (HIV) stigma through a survey of 150 people living with HIV (PLWH) in Hyderabad, India. Survey items to assess social support were adapted from the HIV Cost Services and Utilization Survey. HIV stigma was measured using Zelaya and Jeyaseelan scales that were previously validated in India. Multiple linear regression analysis revealed an inverse association between social support and HIV stigma across both stigma scales. Depression further intensified the level of stigma faced by PLWH who had lower levels of social support. Third‐gender individuals experienced significantly higher HIV stigma and lower social support than cisgender men. Social support must be used as a protective factor in current HIV stigma reduction interventions. Findings highlight the need to adopt a gender‐sensitive social support framework in HIV care policies to better address HIV stigma in the Indian context.
Challenging scalar fallacy in state‐wide welfare studies: AUKsub‐state comparison of civil society approaches to addressing youth unemployment
Authors: Pearce Sioned , Lagana Giada 
Published: November 2022

AbstractHere we make an original, empirical contribution to debates on welfare pluralism, the mixed economies of welfare and territorial rescaling by comparing civil society approaches to tackling youth unemployment in England, Scotland and Wales. Our core finding is that academic and policy literature's frequent characterisation of the UK as a single Liberal welfare regime is based on methodological nationalism privileging state‐wide analyses. In short, a scalar fallacy pervasive in international welfare studies. In the context of the global rise of meso‐government and so‐called ‘stateless nations’ pressing for greater autonomy, our case‐study challenges the dominant paradigm. Our analysis shows the liberal characteristics of work‐first policy orientation and marketised civil society are concentrated in England then tempered by devolved (social) policy. Based on contrasting, left‐of‐centre and civic nationalist governing traditions, grounded in multi‐level electoral politics, we show the devolved nations taking a different approach to Westminster, partially eschewing the market and incorporating collectivism and co‐production.
The affiliative power of others' pain online
Authors: Mitchell Jessie , Occhipinti Stefano , Oaten Megan 
Published: November 2022

AbstractPain is rarely suffered alone. In contemporary online contexts, publicly shared pain can command the collective attention of hundreds, even millions of people. We sought to explore the possibility that collectively attending to others' pain promotes affiliation among those with whom it is attended online and identify the mechanisms that mediate these effects. Across two experimental studies, utilizing independent group designs, physically dispersed undergraduate students attended to real‐world videos depicting either physical, social, or no‐pain online. In Study 1 (N = 74, 66.22% female, Mage = 25.31 years, SDage = 6.81 years), we found evidence for the phenomenon of pain collectively attended to online, with online videos depicting physical and social pain eliciting stronger perceptions of collective attention than the non‐painful online video. In Study 2 (Time 1: N = 185, 75.14% female, Mage = 22.62 years, SDage = 7.44 years; Time 2: N = 91, 72.53% female, Mage = 23.32, SDage = 8.19), we subsequently found collectively attending to others' physical and social pain online indirectly promoted cohesion, interpersonal closeness, and desire to affiliate among participants through perceived emotional synchrony. This pattern of indirect effects was found immediately after collective attention to painful online content (Time 1) and at 1‐week follow‐up (Time 2). Although preliminary, our findings increase practical understanding of how shared pain can be harnessed to bond physically dispersed individuals together online, the implications of which we discuss in the context of the COVID‐19 pandemic.
Optimal local impedance parameters for successful pulmonary vein isolation in patients with atrial fibrillation
Authors: Fukaya Hidehira , Mori Hitoshi , Oikawa Jun , Kawano Daisuke , Nakamura Hironori , Ishizue Naruya , Kishihara Jun , Hojo Rintaro , Tsutsui Kenta , Ikeda Yoshifumi , Kato Ritsushi , Fukamizu Seiji 
Published: November 2022

AbstractIntroductionLocal impedance (LI) parameters of IntellaNav STABLEPOINT for successful pulmonary vein isolation (PVI) of atrial fibrillation (AF) remain unclear. The purpose of this study was to seek LI data achieving successful PVI.MethodsConsecutive AF patients who underwent catheter ablation with STABLEPOINT were prospectively enrolled in two centers. PVI was performed under a constant 35‐or 40‐watt power, 20‐s duration, and >5‐g contact force. The operators were blinded to the LI data. The characteristics of all ablation points with/without conduction gaps (Unsuccess or Success tags) after the first‐attempt PVI were evaluated for the right/left PVs and anterior/posterior wall (RPV/LPV and AW/PW, respectively), and cutoff values of LI data were calculated for successful lesion formation.ResultsA total of 5257 ablation points in 102 patients (65 [58–72] years old, 65.7% male) were evaluated. The LI drop values were higher in the Success tags than Unsuccess tags on the LPV‐AW and RPV‐AW/PW (p < .001), except for the LPV‐PW (p = .105). The %LI drop values (LI drop/initial LI) were higher for the Success tags in all areas (15.8 [12.2%–19.6%] vs. 11.6 [9.7%–15.6%] in LPV‐AW: p < .001, 15.0 [11.5%–19.3%] vs. 11.4 [8.7%–17.3%] in LPV‐PW: p = .035, 15.3 [11.5%–19.4%] vs. 9.9 [8.1%–13.7%] in RPV‐AW: p < .001, and 13.3 [10.1%–17.4%] vs. 8.1 [6.3%–9.5%] in RPV‐PW, p < .001). The LI drop and %LI drop cutoff values were 20.0 ohms and 11.6%, respectively.ConclusionsAn insufficient LI drop with STABLEPOINT was associated with a gap formation during PVI, and the best cutoff values for the LI drop and %LI drop were 20.0 ohms and 11.6%, respectively.
Prevalence of atrial fibrillation and procedural outcome in patients undergoing catheter ablation for premature ventricular complexes
Authors: Zou Fengwei , Di Biase Luigi , Mohanty Sanghamitra , Zhang Xiaodong , Shetty Sai Shishir , Gianni Carola , Della Rocca Domenico G. , Lin Aung , Arosio Roberto , Schiavone Marco , Forleo Giovanni , Mayedo Angel , MacDonald Bryan , Al‐Ahmad Amin , Bassiouny Mohamed , Gallinghouse G. Joseph , Horton Rodney , Burkhardt John D. , Natale Andrea 
Published: November 2022

AbstractIntroductionAtrial fibrillation (AF) and premature ventricular complexes (PVC) are common arrhythmias. We aimed to investigate AF prevalence in patients with PVC and its impact on PVC ablation outcomes.MethodsConsecutive patients undergoing PVC ablation at a single institution between 2016 and 2019 were included and prospectively followed for 2 years. Patients with severe valvular heart disease, hyperthyroidism, malignancy, alcohol use disorder and advanced renal/hepatic diseases were excluded. Twelve‐lead electrocardiograms were used to diagnose AF and assess PVC morphology. All PVCs were targeted for ablation using 4‐mm irrigated‐tip catheters at standardized radiofrequency power guided by 3‐D mapping and intracardiac echocardiography. Patients were followed with remote monitoring, device interrogations and office visits every 6 months for 2 years. Detection of any PVCs in follow‐up was considered as recurrence.ResultsA total of 394 patients underwent PVC ablation and 96 (24%) had concurrent AF. Patients with PVC and AF were significantly older (68.2 ± 10.8 vs. 58.3 ± 15.8 years, p < .001), had lower LV ejection fraction (43.3 ± 13.3% vs. 49.6 ± 12.4%, p < .001), higher CHA2DS2‐VASc (2.8 ± 1.3 vs. 2.0 ± 1.3, p < .001) than those without. PVCs with ≥2 morphologies were detected in 60.4% and 13.7% patients with vs without AF (p < .001). At 2‐year follow‐up, PVC recurrence rate was significantly higher in patients with vs without AF (17.7% vs. 9.4%, p = .02).ConclusionAF was documented in 1/4 of patients undergoing PVC ablation and was associated with lower procedural success at long‐term follow‐up. This was likely attributed to older age, worse LV function and higher prevalence of multiple PVC morphologies in patients with concurrent AF.
Efficacy of professionally administered chemical agents as an adjunctive treatment to sub‐marginal instrumentation during the therapy of peri‐implant mucositis
Authors: Dommisch Henrik , Hoedke Daniela , Valles Cristina , Vilarrasa Javi , Jepsen Søren , Pascual La Rocca Andres 
Published: November 2022

AbstractAimTo evaluate the efficacy of professionally administered chemical agents as an adjunctive treatment to sub‐marginal instrumentation (SMI) in the therapy of peri‐implant mucositis.Materials and MethodsThe primary outcome criteria were reduction in bleeding on probing (BOP), whereas resolution of disease, elimination of suppuration, including suppuration on probing, reduction of peri‐implant probing pocket depth, reduction of plaque, and patient‐reported outcome measures were considered as secondary outcome parameters. A literature search was performed on three electronic databases (01/1980 to 05/2022) focused on clinical studies with at least 3 months of follow‐up, and meta‐analyses were performed when appropriate.ResultsFrom a total of 139 publications, 40 articles were identified for full‐text reading, and 5 randomized controlled clinical trials (RCTs) on antimicrobial photodynamic therapy (aPDT), 1 RCT on chlorhexidine (CHX), and 1 RCT on sodium hypochlorite (NaOCl) were included. Three studies had a low risk of bias and four had a mid‐level (some concerns) risk of bias. The application of aPDT, 0.95% NaOCl, or 0.12% CHX as an adjunctive treatment to SMI showed no difference in changes in BOP and PD compared with SMI alone (p > .05).ConclusionsWithin the limitations of this review and based on a low level of evidence from seven RCTs, it is concluded that the professional adjunctive topical application of aPDT, 0.95% NaOCl, and 0.12% CHX may not be effective to improve changes for BOP and PD when compared with SMI alone.
Efficacy of chemical approaches for implant surface decontamination in conjunction with sub‐marginal instrumentation, in the non‐surgical treatment of peri‐implantitis: A systematic review
Authors: de Waal Yvonne C. M. , Winning Lewis , Stavropoulos Andreas , Polyzois Ioannis 
Published: November 2022

AbstractAimTo answer the following PICOS question: In adult patients with peri‐implantitis, what is the efficacy of sub‐marginal instrumentation combined with chemical surface decontamination in comparison with sub‐marginal instrumentation with or without placebo, in terms of changes in probing depth (PD) and/or bleeding on probing, as reported in prospective randomized controlled trials, non‐randomized controlled trials, or prospective cohort studies, with a minimum of 6‐month “follow‐up”.Materials and MethodsA systematic literature search was performed in PubMed, Web of Science, Embase, Scopus, Ovid Medline, and The Cochrane Library of the Cochrane Collaboration (CENTRAL) for articles published until March 2022. Data addressing the primary and secondary outcomes were extracted.ResultsThe search gave 2033 results of which 3 fulfilled the inclusion criteria. Two studies investigated the use of anti‐microbial photodynamic therapy as adjunct to sub‐marginal instrumentation and the third study assessed the adjunctive use of a desiccant material. A meta‐analysis was not deemed meaningful because of the large heterogeneity among the studies. All three studies showed favourable results in terms of PD reduction for chemical surface decontamination over control approaches, but were inconsistent or showed no differences for the other outcome variables.ConclusionsAdjunctive chemical approaches for implant surface decontamination may offer an advantage over sub‐marginal instrumentation alone, in terms of improved PD.
Effect of cold plasma on different polyphenol compounds: A review
Authors: Kumar Sitesh , Pipliya Sunil , Srivastav Prem Prakash 
Published: November 2022

AbstractThermal processing has been predominantly used in the food industry to improve food safety and shelf life. However, heat treatment induces detrimental effects like cooked flavor, texture change, and alteration in sensory attributes. These disadvantages encouraged the food industry to adopt non‐thermal food processing technologies. Cold plasma is a promising non‐thermal food processing method that uses charged, highly reactive gaseous molecules and species to inactivate contaminating microorganisms present in foods. Thus, it has attracted the attention of scientists globally. This review gives the reader an overview of cold plasma technology fundamentals and the detailed mechanism of interaction of reactive plasma species with the polyphenol compounds (simple phenolic acid, individual phenolic compounds, flavonoids, and anthocyanin) present in food. The impact of cold plasma on polyphenol compounds mainly depends on the food matrix and plasma process parameters, viz. voltage, feed gas, and treatment time. Among various polyphenols, flavonoids are degraded faster because of their high ability to scavenge plasma‐generated free radicals. The reactive species cause oxidative degradation, double bond cleavage of polyphenol compounds, and aid in the extraction of phenolic compounds. The cold plasma technology has both positive and negative impacts on polyphenol concentration.
Core microbiome of corals Pocillopora damicornis and Pocillopora verrucosa in the northeastern tropical Pacific
Authors: Ostria‐Hernández Martha L. , Hernández‐Zulueta Joicye , Vargas‐Ponce Ofelia , Díaz‐Pérez Leopoldo , Araya Rubén , Rodríguez‐Troncoso Alma P. , Ríos‐Jara Eduardo , Rodríguez‐Zaragoza Fabián A. 
Published: November 2022

AbstractIdentifying the core microbiome structure of a metaorganism can be used to monitor the impact of a perturbation against it and the changes in its stability (i.e., dysbiosis), resistance, and resilience. The core‐microbiome interaction regulates holobiont health and homeostasis and is an indicator of the resilience of the whole community. This study determined the exclusive and shared core microbiome taxa of two reef‐building coral species (Pocillopora damicornis and P. verrucosa), as well as the surrounding seawater and sediment, in six coral communities along the Northeastern tropical Pacific region. We also analysed the putative metabolic functions of the most abundant OTUs of these core microbiomes and evaluated the influence of anthropogenic stressors (i.e., tourism, fishery, eutrophication, among others) on core microbiome composition. Bacterial diversity was assessed by sequencing the V4 region of the 16S rRNA. The bacterial families Planctomycetaceae, Oceanospirillaceae, and Moraxellaceae presented the highest relative abundances in corals samples, while Flavobacteriaceae and Rhodobacteraceae dominated in seawater samples. In the sediment samples, Pseudoalteromonadaceae, Oxalobacteraceae, Moraxellaceae, and Pseudonocardiaceae had the highest representation. The core microbiomes of the two coral species, seawater, and sediment, shared 571 OTUs. The P. damicornis core microbiome varied between sites with low and moderately‐high anthropogenic stressors. The core microbiomes of both coral species showed an increase in the relative abundance of the families Planctomycetaceae and Pseudomonadaceae in the sites with moderate‐high anthropogenic stressors, associated with higher values of ammonium, chlorophyll a, and extinction coefficient. In contrast, the core microbiome of P. verrucosa, seawater, and sediments did not vary between sites with different anthropogenic stress conditions. Aerobic chemoheterotrophy was the metabolic function with the highest occurrence in all substrates' core microbiomes, followed by ureolysis and photoautotrophy.