bluuebunny/crossref_metadata_2025_split huggingface dataset:
Do pre-existing medical conditions affect COVID-19 incidence and fatality in Nigeria? A Geographical Perspective
Authors: Osayomi Tolulope , Adeleke Richard , Yaya Sanni , Ayanda Joy Temitope , Akpoterai Lawrence Enejeta , Fatayo Opeyemi Caleb 
Published: April 2022

AbstractClinical evidence shows the incidence of novel coronavirus is associated with pre-existing medical conditions. Thus, people with pre-existing medical conditions are more likely to be infected with COVID-19. In light of this, this paper examined the extent to which pre-existing medical conditions are related to COVID-19 incidence and mortality in Nigeria from a geographical perspective. We used the geographically weighted regression (GWR) to determine the effect and extent to which pre-existing medical conditions affect COVID-19 incidence in Nigeria. Our findings show that besides the remarkable spatial variation in COVID-19 incidence and mortality, obesity was a significant predictor of COVID-19 with its effect strongest in southwest Nigeria and other parts of the country. The conclusion of the paper is that areas with high prevalence of pre-existing medical conditions coincide with areas with high COVID-19 incidence and fatality. We recommended that there should be a spatially explicit intervention on the reduction of exposure to COVID-19 among states with high prevalence of pre-existing medical conditions through vaccination.
High-temperature behavior and structural studies on Ca14Al10Zn6O35
Authors: Kahlenberg Volker , Krüger Hannes 
Published: April 2022

Abstract
Single-crystals of Ca14Al10Zn6O35 suitable for structural investigations were grown from slow cooling of a melt with the same chemical composition in the range between 1300 and 1000 °C. Diffraction experiments performed at ambient temperature yielded the following crystallographic data: space group F23, a = 14.8468 (6) Å, V = 3272.6 (2) Å3, Z = 4. Structure determination and subsequent least‐squares refinements resulted in a residual of R(|F|) = 1.49% for 753 independent observed reflections and 55 parameters. The chiral structure is based on a tetrahedral framework of corner sharing (Zn,Al)O4-tetrahedra. Zn–Al-distributions among the four crystallographically independent T-sites have been studied. A detailed topological analysis based on natural tiles is presented. Actually, the net can be constructed from a total of four different cages (tiles). The largest cavities (face symbol: [316. 616]) have volumes of about 680 Å3 and host [AlO6][Ca14O36] heteropolyhedral clusters consisting of a central [AlO6] – octahedron surrounded by [CaO6]- and [CaO7]-groups. The calcium cations provide linkage to the tetrahedral framework, in other words, the [AlO6]-unit in the barycenter of the cluster is not directly connected to the framework. Furthermore, thermal expansion has been studied in the interval between 25 and 790 °C using in-situ high‐temperature single‐crystal diffraction. No indications for a structural phase transition were observed. From the evolution of the lattice parameters the thermal expansion tensor has been obtained. The response of the structure to variable temperature has been discussed.
NCAA Student-Athlete Training During COVID-19 Stay-At-Home Restrictions
Authors: Koziris Lymperis (Perry) 
Published: April 2022

ABSTRACT
The effects of COVID-19 restrictions were ubiquitous, including decreased physical activity globally. A recent study showed significant consequences on American student-athletes, who were forced to stay at home between March and June 2020. Inadequacy of equipment and programming hampered the resulting improvised training. Resistance exercise was the second most common mode used after cardiovascular exercise, and the primary equipment utilized was dumbbells and resistance bands. More women than men did not resistance train. More women believed they were eating less and healthier. Sleep length and disturbances increased; the latter more in women. Mental health concerns and decreased motivation to train became more frequent, especially within Division III more than Division I. The most-reported overall concerns were maintenance of fitness, sport-specific training, and health, possibly implicating the equipment/programming barriers as contributors to negative psychological effects. Providers of S&C, mental health, and other support services should plan for athletes' home situations toward any future extended lockdown.
A Graphene Oxide–Based Hydrogel with Excellent Adhesive, Tough, and Antibacterial Properties
Authors: Chai Maozhou , An Meiwen , Zhang Xiangyu 
Published: April 2022

Abstract
Hydrogels have attracted extensive attention in the field of wound dressing because of the high water content and a structural similarity to human soft tissue. However, the hydrogels are usually vulnerable and easy to be destroyed during movement. Moreover, the hydrogels without antibacterial function cannot prevent bacterial infection during chronic wound healing. In this work, graphene oxide (GO) containing polyacrylamide hydrogel with both adhesiveness and superior mechanical properties was prepared. Since GO possesses good photothermal conversion capability and photodynamic property, the hybrid hydrogel exhibits excellent antibacterial property under the irradiation of near-infrared light.
Screening of antibacterial activities of Bacillus spp. isolated from the Parangkusumo coastal sand dunes, Indonesia
Authors: Geraldi Almando , Famunghui Margareth , Abigail Mercyana , Siona Saragih Chesa Febrizky , Febitania Devina , Elmarthenez Henrietta , Putri Cinantya Aulia , Putri Merdekawati Ummi Amaliatush Sholichah , Sadila Aliffa Yusti , Wijaya Nabilla Hapsari 
Published: April 2022

Abstract

Background: The emergence of multidrug-resistant bacteria because of poor understanding of the issue and the misuse of antibiotics has become global health concern. Therefore, the discovery of novel antibacterial drugs is urgently needed. New antibacterial compounds may be found in the Bacillus species, which are abundant in sand dune ecosystems. Herein, we examined samples from the Parangkusumo coastal sand dunes in Indonesia.

Methods: Samples were collected from three areas in the sand dunes (the area closest to the sea, the core area of sand dunes, and the area farthest from the sea). The samples were inoculated on Luria Bertani agar. Morphological and molecular identification was performed on the basis of 16S rRNA. The samples’ antimicrobial activity was evaluated with the disc diffusion method and compared with that of opportunistic pathogenic bacteria.

Results: Five species of Bacillus were successfully isolated from the Parangkusumo coastal sand dunes. To our knowledge, this is the first report of the isolation of Bacillus aryabhattai in Indonesia. All samples showed antimicrobial activity against pathogenic bacteria. B. velezensis and B. subtilis showed antibacterial activity against Gram-positive bacteria, whereas B. aryabhattai and B. megaterium showed antibacterial activity against Gram-negative bacteria, and B. spizizenii showed antibacterial activity toward Gram-positive and Gram-negative bacteria.

Conclusion: Five Bacillus species were successfully isolated from the Parangkusumo coastal sand dunes, Indonesia, and all samples showed antimicrobial activity toward opportunistic pathogenic bacteria. The crude antimicrobial compounds from B. megaterium, B. aryabhattai, B. subtilis, and B. spizizenii showed the highest growth-inhibition activity against E. coli, P. aeruginosa, B. cereus, and S. aureus, respectively.
EKSISTENSI SPESIES IKAN INTRODUKSI PADA HASIL TANGKAPAN NELAYAN JARING INSANG (GILLNET) DI PERAIRAN WADUK PANGLIMA BESAR SOEDIRMAN KABUPATEN BANJARNEGARA
Authors: Kurnia Dhimas Ragil , Sukardi Purnama , Iqbal Achmad 
Published: April 2022

Waduk Panglima Besar Soedirman, Kabupaten Banjarnegara, merupakan waduk dengan fungsi untuk pembangkit listrik, irigasi pertanian, pariwisata, budidaya dan penangkapan ikan. Jaring Insang (Gillnet) merupakan salah satu alat tangkap yang banyak digunakan oleh nelayan perairan Waduk PB Soedirman. Tujuan dari penelitian ini adalah untuk mengetahui komposisi jenis-jenis hasil tangkapan nelayan jaring insang (gillnet) di Waduk Panglima Besar Soedirman, baik jenis introduksi maupun jenis lokal dan juga untuk mengetahui tingkat dominansi antar spesies dan dominansi antara ikan jenis introduksi dan ikan jenis lokal hasil tangkapan nelayan jaring insang (gillnet) di Waduk Panglima Besar Soedirman. Penelitian ini dilaksanakan pada bulan Juni sampai dengan Agustus 2019. Data jenis-jenis ikan hasil tangkapan nelayan gillnet dianalisis menggunakan rumus komposisi jenis dan rumus indeks dominansi Simpson (C). Jenis-jenis ikan hasil tangkapan nelayan jaring insang (gillnet) di Waduk Panglima Besar Soedirman diantaranya adalah Nila (Oreochromis niloticus) sebanyak 51%; Louhan (Cichlasoma trimaculatum) 21%; Betutu (Oxyeleotris marmorata) 21%; Tawes (Barbonymus gonionotus) 3%; Nilem (Osteochillus vittatus) 2%; Gabus (Channas triata) 1%; Mas (Ciprinus carpio) 1%; dan Bawal (Collosoma macropomum) 0,14%. Jenis-jenis ikan yang termasuk dalam jenis ikan introduksi adalah Nila (Oreochromis niloticus), Louhan (Cichlasoma trimaculatum), Betutu (Oxyeleotris marmorata), Mas (Ciprinus carpio) dan Bawal (Collosoma macropomum) dengan jumlah prosentase 94%. Jenis-jenis ikan yang termasuk ikan lokal adalah Tawes (Barbonymus gonionotus), Nilem (Osteochillus vittatus) dan Gabus (Channas triata) dengan prosentase prosentase 6%. Nilai indeks dominansi (C) antar spesies adalah 0,3538 yang berarti tingkat dominansi sedang dan nilai indeks dominansi (C) antara ikan jenis introduksi dan ikan jenis lokal adalah 0,8981 yang berarti tingkat dominansi tinggi.
Aloin promotes oral squamous cell carcinoma cell apoptosis and autophagy through Akt/mTOR pathway
Authors: Hu Yongxin , Xiang Xiaosong , Zhang Yuhui , Tian Zhongqi , Wang Lijian 
Published: April 2022

Aloin, a natural product, has demonstrated anticancer activity in a variety of cancers, but its role in oral squamous cell carcinoma (OSCC) has not been reported. In this study, we aimed to investigate the effects of Aloin on the biological functions of OSCC cells. Additionally, we evaluated the classical Akt/mTOR signal transduction pathway. CAL-27 OSCC cells were treated with Aloin for in vitro experiments. 5-bromo-2’-deoxyuridine (BrdU) and colony formation assays were applied to evaluate cell proliferation potential. Wound scratch and Transwell assays detected cell migration and invasion, respectively. Flow cytometry detected apoptosis. Autophagy was assessed by p62, Beclin-1, light chain 3 (LC3)-I and LC3-II protein expressions through Western blot test. Akt/mTOR signal pathway-related protein levels were also detected by Western blot test. Here, compared with the control group, Aloin treatment memorably reduced the number of BrdU-positive cells and colonies, and undermined the ability of cell migration and invasion. Moreover, Aloin promoted apoptosis and autophagy. Western blot test proved that the protein expression of p62 was down-regulated, while Beclin-1 and LC3-I/LC3-II protein expressions were up-regulated. Further investigations revealed that Aloin inhibited p-Akt and p-mTOR, suggesting that Aloin could block the activation of AKT/mTOR pathway. Our findings demonstrated that Aloin could inhibit the activation of the AKT/mTOR pathway to induce autophagic cell death, which could provide a novel vision for OSCC treatment.
Exame Químico-Metalográfico e Identificação Veicular em Automotor do Tipo Motocicleta: Relato de Caso
Authors: De Paula Miranda Leonardo , Lopes Oliveira Thatiane 
Published: April 2022

Os exames de identificação veicular e ensaio químico-metalográfico são atribuições frequentemente realizadas pelo perito criminal. Destarte, o objetivo deste estudo foi identificar uma motocicleta mediante avaliação dos seus elementos identificadores e execução de exame químico-metalográfico no Número de Identificação Veicular (NIV) e sequencial alfanumérico do motor, a fim de se recuperar os caracteres originais adulterados. Trata-se de um relato de caso concernente a um automotor do tipo motocicleta, a qual exibia pintura automotiva preta e desprovida de placa alfanumérica de identificação veicular. Por meio de análise macroscópica dos elementos de identificação do veículo, constatou-se inicialmente: pintura em cor vermelha subjacente a preta disposta no tanque de combustível; plaqueta afixada ao chassi veicular manifestando características de originalidade e expressando o ano de fabricação 1999; as sequências alfanuméricas presentes no NIV e motor haviam sido, respectivamente, parcialmente e integralmente suprimidas por ação mecânica. Após preparo das superfícies metálicas do chassi e motor, aplicaram-se sobre o NIV o reagente Besseman e sobre a liga metálica do motor o ácido clorídrico concentrado (35%). Posteriormente à aplicação dos reativos, observou-se a revelação dos caracteres subjacentes originais integralmente pertencentes ao NIV, bem como se evidenciou quase que de forma integral os caracteres gravados no motor veicular. Assim, por meio dos exames elencados, foi tecnicamente possível identificar o automotor analisado. Ademais, salienta-se há uma lacuna literária relativa à temática abordada no campo das ciências forenses, o que enseja a realização de novos estudos e relatos similares.
Sociable Space and Social Policies in Iranian Urban Local Communities
Authors: Валибейги Моджтаба , Серешти Марьям 
Published: April 2022

Changes in the spatial arrangement and dominant social processes of urbanization over the past few decades in Iran have failed to allow communities to shape their social interactions. This paper is a synthesis of a quantitative and qualitative study of community responses aimed at creating good social spaces within local communities in Tehran. First, we identified Perceived Residential Environment Quality indicators (PREQ) as tools for determining the effects of environmental quality (EQ) of sociable spaces. Then key social governance-­related concerns were studied on the basis of five questions including: Are the decision-­making and regulatory processes open, rigorous and accountable? Is the environmental quality assessment process adequate? Does the government have the intention and capacity to monitor and enforce regulations? Has the interaction of community members in decisions been timely and have local actors been significantly involved? Have local governments been included in decision making? It is observed that community residents identified systematic gaps and problems in decision-­making processes and sometimes even used them to advance individual interests, because they do not feel that they are dealt with justice and see the current laws as depriving them of access to more resources. In many cases, regulatory protections and assessments of social and environmental values lagged behind the physical construction. Administrative bureaucracies without creating a real participation have been increased. Overall, we argue that as a common ground, environmental activities can bring together people in the local community but when such functioning systems are put in place to ensure community engagement. So, despite extensive formal endorsement, they should provide for an effective as opposed to a symbolic involvement of stakeholders other than governmental authorities.
NILAI ESTETIS RIAS DAN BUSANA TARI TANI MELATI DESA KALIPRAU SANGGAR SENI KALOKA KABUPATEN PEMALANG
Authors: Mahesa Gessila Siva , Indriyanto R 
Published: April 2022

Abstract: Make-up are visual aspects in the elements of dance, which means make-up or grooming and dressing aimed at inviting the audience's attention to enjoy and interpret the content of dance offerings. The aesthetic value of the make-up and clothing of Tani Melati Dance includes the appearance value, the content or meaning value, the expression value of each form, process, color that combines the combination of results of jasmine flower ronce as village branding in realizing the purity of jasmine sambac and the activities of jasmine farmers. Key Words: Aesthetic Value, Make-up, Tani Melati Dance Abstrak: Rias dan busana adalah aspek visual dalam unsur elemen tari yang berarti berias atau dandan dan berbusana yang bertujuan untuk mengundang perhatian penonton untuk menikmati dan menginterpretasikan isi sajian tari. Nilai esteis rias dan busana Tari Tani Melati meliputi nilai kesan penampilan, nilai isi atau makna, nilai pengungkapan dari setiap perpaduan bentuk, proses, warna yang menggabungkan perpaduan dari hasil ronce bunga melati sebagai branding desa dalam mewujudkan kemurnian Jasmine Sambac dan aktivitas petani melati. Kata kunci: Nilai Estetis, Rias dan Busana, Tari Tani Melati
Rancang Bangun Prototipe Pemanen Energi Getaran pada Speed Bump Menggunakan Tranducer Piezoelectric
Authors: Pratama Legenda Prameswono , Herdiyansyah Rizal Agus , Manfaluthy Mauludi 
Published: April 2022

Listrik adalah salah satu aspek penting bagi manusia untuk menjalankan segala kegiatan sehari-hari. Seiring dengan terus meningkatnya jumlah penduduk, maka kebutuhan akan pemakaian energi listrik juga semakin meningkat. Namun, sebagian besar konsumen energi listrik masih mengandalkan PLN (Perusahaan Listrik Negara), sehingga diperlukan banyak inovasi di bidang ketenagalistrikan, terutama energi alternatif yang ramah lingkungan. Dengan memanfaatkan jumlah penduduk yang terus meningkat tiap tahunnya, maka dibuatlah alat yang dapat mengkonversikan energi tekanan dari kendaraan sepeda motor manjadi energi listrik. Metode yang digunakan didalam penelitian ini adalah metode eksperimental. Studi ini telah berhasil mengintegrasikan teknologi daur ulang energi dalam sebuah konsep pemanenan energi menggunakan tranduser piezoelectric yang divalidasi menggunakan 200 kali pijakan pada prototipe speed bump. Dari total 200 kali pijakan pada speed bump tegangan yang disimpan pada ACCU terus mengalami kenaikan tetapi tegangan yang dihasilkan oleh piezoelectric terus mengalami penurunan pada 50 pijakan pertama yaitu penambahannya sebesar 1,1V dimana tegangan ACCU awal adalah 3,4 V menjadi 4,5 V, dipijakan ke 100 penambahan tegangan masih stabil yaitu sebesar 1,1 V, dipijakan ke 150 mulai terjadi penurunan interval yaitu menjadi 0,9V, dipijakan terakhir yaitu pijakan ke 200 terjadi lagi penurunan yaitu menjadi 0,5 V.
Comparing the effects of alternate day and daily thyroxine replacement therapy in subclinical hypothyroidism
Authors: Mishra Sanjay , Gupta Arjit 
Published: April 2022

Background: Subclinical hypothyroidism (SCH) is defined as serum thyroid-stimulating hormone (TSH) level above upper limit of normal despite normal levels of serum free thyroxine. According to recommendations, L-thyroxine treatment for hormone replacement therapy should be continued on daily basis. However, some trials have challenged daily regimen for management of hypothyroidism and have suggested dosage scheduling at weekly, twice-a-week or alternate day as possible alternatives having similar effect as for daily regimen.Methods: Study was prospective randomized cross-over intervention design. Thyroid functions (T3, T4 and TSH) were measured using third generation non-isotopic immunochemiluminescence method using standard protocol. 120 patients with clinically established hypothyroidism were enrolled in study.Results: Difference in mean TSH levels of group I and group II were not found to be statistically significant at baseline (8.247±2.288 mIU/ml versus 8.210±2.650; p=0.935), at 6 weeks (2.337±1.792 mIU/ml versus 2.843±2.410 mIU/ml; p=0.195) and at 12 weeks (2.508±1.180 mIU/ml versus 2.831±1.200 mIU/ml; p=0.191). Difference in mean T3 levels of group I and group II were not found to be statistically significant at baseline (1.118±0.199 ng/dl versus 1.184±0.187 ng/dl; p=0.061), at 6 weeks (1.266±0.295 ng/dl versus 1.196±0.289 ng/dl; p=0.192) and at 12 weeks (1.121±0.211 ng/dl versus 1.179±0.203 ng/dl; p=0.174). Difference in mean T4 levels group I and group II were not found to be statistically significant at baseline (8.422±2.054 µg/dl versus 7.899±2.333 µg/dl; p=0.196), at 6 weeks (8.852±2.836 µg/dl versus 8.533±2.672 µg/dl; p=0.527) and at 12 weeks (8.159±2.235 µg/dl versus 7.990±2.463 µg/dl; p=0.728).Conclusions: The findings of present study show that alternate day L-thyroxine is a viable solution for the management of SCH.
Urinary bladder paraganglioma: a clinical dilemma in diagnosis and management: our experience at a tertiary care center
Authors: Kriplani Akshay , Jain Deep , Kulshreshtha Mayank , Jayadeva Reddy Suraj , Pandit Shruti , Reddy Bathi Sourabh , Sachdev Gurvansh Singh , Hiremath Vivekanand Kedarlingayya , Chawla Arun 
Published: April 2022

Urinary bladder paraganglioma (UBP) are rare neuroendocrine tumors with variable biological behavior. High index of suspicion in the preoperative evaluation would enable the clinician to formulate appropriate management of the rare tumors. Clinical and pathological data of seven cases evaluated and treated as per a devised protocol for suspected bladder paraganglioma from 2008 to 2019 was retrospectively reviewed. Among the seven cases, UBP’s were predominantly seen in middle aged men. Most of these presented with storage symptoms (85.71%; n=7) and gross painless hematuria (42.85%; n=3). Three patients were hypertensives and post-micturition syncope was seen in two patients. Among the seven patients two patients had functionally active tumors confirmed by elevated urinary and serum markers for catecholamine excess. Functional tumors, nonfunctional tumors involving uretero-vesical junction or broad based polypoidal tumor were considered for partial cystectomy. Other small nonfunctional tumors underwent trans-urethral resection of bladder tumour (TURBT). Follow up protocol included repeat ultrasound, check cystoscopy and completion TURBT at one month and annually thereafter. Repeat urinary catecholamines at 1 month was done in functional UBP. Cystoscopic examination of a bladder lesion which are solid, sessile and predominantly intramural, a prior to a definitive planned surgery may differentiate UBP from urothelial cancer. Most of the non-functional UPB are diagnosed by histopathological examination. In symptomatic cases, functional evaluation with biochemical estimation of catecholamine excess allow better treatment planning and avoiding intraoperative hemodynamic instability. Due to high recurrence rate life-long follow-up despite complete excision is strongly recommended.
Morquio syndrome or something cryptic: think!
Authors: Singh Jasmine , Kumar Pankaj , Randev Shivani , Guglani Vishal 
Published: April 2022

<p class="abstract">Morquio syndrome (MS) or mucopolysaccharidosis type IV A is an autosomal recessive lysosomal storage disorder caused by deficiency of N-acetylgalactosamine-6-sulfate sulfatase. The disorder is marked by characteristic physical features, skeletal abnormalities and normal intellect. We report a nine year old boy who presented with coarse facial features, barrel shaped chest, rhizomelic limb shortening and intellectual disability. Along with facial features, the initial radiological survey pointed to the diagnosis of MS. However when the urinary glycosaminoglycans came to be negative, the radiographs and clinical features were reviewed which led us to a rare syndrome with significantly different treatment and prognosis. A pediatrician should keep a high index of suspicion to pick up mimics of mucopolysaccharidosis as the variable prognosis and management protocol might be life saving in some cases. </p>