bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparative diurnal and seasonal variations of ACTH, cortisol and aldosterone in Ouled Djellal and D’Man sheep breeds reared in arid lands
Authors: AMOKRANE-FERRAH Assia , ANANE ASSIA , BOUKENAOUI-FERROUK NOURIA , KHALDOUN MOUNIRA , AMIRAT ZAINA , MORMEDE PIERRE , KHAMMAR FARIDA 
Published: August 2022

Abstract. Amokrane-Ferrah A, Annane A, Ferrouk-Boukenaoui N, Khaldoun M, Amirat Z, Mormede P, Khammar F. 2021. Comparative diurnal and seasonal variations of ACTH, cortisol and aldosterone in Ouled Djellal and D’Man sheep breeds reared in arid lands. Biodiversitas 23: 388-395. This study aimed to explore the diurnal and seasonal variations of adrenocorticotropic hormone (ACTH), cortisol and aldosterone, main hormones involved in adaptation to the harsh climate of the Sahara Desert in two breeds of sheep (Ovis aries Linnaeus, 1758), Ouled Djellal rams (seasonal breeder) and D'Man (no seasonal breeder). Blood samples were taken every hour for 24 hours during equinoxes and solstices. Plasma ACTH levels were similar in the two breeds, with higher levels in the morning and a seasonal rhythm characterized by lower levels and dampened diurnal cycle in winter. In most experimental conditions, plasma cortisol levels showed no circadian rhythm but marked ultradian variations. The seasonal cortisol rhythm was different from the ACTH rhythm and characterized by lowest levels at equinoxes and highest levels in summer. Mean cortisol levels were higher in Ouled Djellal than in the D’Man breed, which may favor better robustness of Ouled Djellal sheep. Plasma aldosterone levels were characterized by diurnal variations with an acrophase around midnight, with large differences across breeds and seasons. In contrast to cortisol, the seasonal rhythm of plasma aldosterone showed the highest levels at equinoxes and lowest at solstices. These changes can be driven by environmental conditions and exceptionally high summer temperatures.
Measurement of Entangled States Before, During, and After a Proposed Entangled Two-Photon Molecular Excitation
Authors: Hickam Bryce , He Manni , Szoke Szilard , Cushing Scott 
Published: August 2022

Entangled photons are predicted to linearize and enhance the probability of multiphoton processes. We construct an interferometer to measure the quantum state before, during, and after an entangled excitation and distinguish it from one-photon processes.
Comments and questions should be directed to the Optica Conference Papers staff (tel: +1 202.416.6191, e-mail: cstech@optica.org).
Association of race/ethnicity with mortality in patients hospitalized with COVID-19
Authors: Richardson Safiya , Martinez Johanna , Hirsch Jamie S. , Cerise Jane , Lesser Martin , Roswell Robert O. , Davidson Karina W. ,   the Northwell Health COVID-19 Research Consortium
Published: August 2022

Objective
To evaluate racial and ethnic differences in mortality among patients hospitalized with coronavirus disease 2019 (COVID-19) after adjusting for baseline characteristics and comorbidities.

Methods
This retrospective cohort study at 13 acute care facilities in the New York City metropolitan area included sequentially hospitalized patients between March 1, 2020, and April 27, 2020. Last day of follow up was July 31, 2020. Patient demographic information, including race/ethnicity and comorbidities, were collected. The primary outcome was in-hospital mortality.

Results
A total of 10 869 patients were included in the study (median age, 65 years [interquartile range (IQR) 54–77; range, 18–107 years]; 40.5% female). In adjusted time-to-event analysis, increased age, male sex, insurance type (Medicare and Self-Pay), unknown smoking status, and a higher score on the Charlson Comorbidity Index were significantly associated with higher in-hospital mortality. Adjusted risk of hospital mortality for Black, Asian, Hispanic, multiracial/other, and unknown race/ethnicity patients were similar to risk for White patients.

Conclusions
In a large diverse cohort of patients hospitalized with COVID-19, patients from racial/ethnic minorities experienced similar mortality risk as White patients.
Is there an association between pelvic organ prolapse and oxidative stress? A systematic review
Authors: Habes Dominik , Kestranek Jan , Stranik Jaroslav , Kacerovsky Marian , Spacek Jiri 
Published: August 2022

Introduction and hypothesis
The pathophysiology of pelvic organ prolapse (POP) has not been fully elucidated, although accumulating evidence suggests that oxidative stress is involved. The present systematic review comprehensively discusses this topic.

Methods
The PubMed/Medline, Scopus, and Web of Science databases were searched for relevant studies published up to May 2021. This systematic review was registered in the PROSPERO database (registration number CRD42021242240). Two independent researchers screened and selected articles that fulfilled predefined inclusion criteria, performed a quality assessment, and extracted the relevant data. Of 901 original articles retrieved, 8 fulfilled the selection criteria and were included in the review.

Results
Elevated levels of markers of oxidative stress, such as advanced glycation end products, hydroxynonenal and hydroxydeoxyguanosine, were found in various parts of the pelvic floor of patients with POP. Accordingly, the levels of glutathione peroxidase and superoxide dismutase, known as major antioxidant enzymes, were reduced, compared to those in healthy controls. Levels of two other markers (mitofusin 2 and nuclear factor erythroid derived 2) also support hypotheses suggesting the involvement of oxidative stress in POP.

Conclusions
In the literature available, an association between oxidative stress and pelvic organ prolapse was confirmed.
Perception towards preeclampsia and perceived barriers to early health-seeking among pregnant women in selected Hospitals of South Gondar Zone, Northwest Ethiopia: A qualitative study
Authors: Mekie Maru , Bezie Minale , Melkie Abenezer , Addisu Dagne , Chanie Ermias Sisay , Bayih Wubet Alebachew , Biru Shimeles , Hailie Mekonnen , Seid Tigist , Dagnew Enyew , Muche Tewachew , Alemu Eshetie Molla 
Published: August 2022

Background
Preeclampsia is one of the top maternal morbidity and mortality that disproportionately affects pregnant women in low and middle-income countries where access and quality of health services are limited. People in different areas perceive preeclampsia differently which directly or indirectly affects the timing and place of heath seeking. Positive perception about perceived causes, perceived complications, and prevention of preeclampsia is central for the prediction and early diagnosis of the disease. However, little is known about the perception of pregnant women towards preeclampsia in Ethiopia. This study aimed to assess the perception towards preeclampsia and perceived barriers to early health-seeking among pregnant women in selected Hospitals of South Gondar Zone, Northwest Ethiopia.

Methods
A qualitative study using phenomenological approach was implemented among 20 purposively selected pregnant women who visited health facilities for antenatal care service in four selected Hospitals of the South Gondar Zone of the Amhara Region. Data were collected through an in-depth interview (IDI) using a semi-structured interview guide from January to February 2020. Thematic analysis was executed using Open Code Software version 4.03.

Results
The majority of the participants believed preeclampsia as a pregnancy-specific hypertensive disease and mainly associated it with overweight and nutritional problems. With regards to the perceived severity, the study participants agreed that preeclampsia can lead women to death. Personal delay, lack of awareness about the disease, transport problem, and low socioeconomic condition were perceived as the major reasons for the delay to early health-seeking (the 1st and the 2nd delay). While poor service provision and long waiting times were the barriers to receive services at the health facility level (the 3rd delay).

Conclusion
The majority of the participants believed preeclampsia as a pregnancy-specific hypertensive disease and mainly associated it with overweight and nutritional problems. The finding of this study implied that awareness creation about the danger of hypertension during pregnancy and its risk reduction mechanisms shall be emphasized. The care provision at health facilities shall be improved by decreasing long waiting time which discourages service utilizations aside from improving early seeking behavior of pregnant women through different interventions.
Experiences and perceptions of people with a severe mental illness and health care professionals of a one-year group-based lifestyle programme (SMILE)
Authors: Walburg Florine , de Joode Johanna Willemina , Brandt Hella , van Tulder Maurits , Adriaanse Marcel , van Meijel Berno 
Published: August 2022

Objective
This was to elucidate the experiences and perceptions of people with severe mental illness (SMI) and their health care professionals with the SMILE (Severe Mental Illness Lifestyle Evaluation) group-based lifestyle intervention. SMILE focuses primarily on promoting healthy diet, physical activity and weight loss.

Method
A qualitative study with semi-structured interviews was conducted using purposive sampling. Interviews were conducted with 15 clients and 13 health care professionals (HCPs). Data were analysed according to a thematic analysis.

Results
Four overall themes were identified: interest in a lifestyle programme; group-based setting; changes in lifestyle behaviour; and preconditions for changing health behaviour. The results showed that clients valued the programme and were interested in the subject of lifestyle. The group-based setting was seen as a positive and important aspect of the intervention. Making lifestyle changes was acknowledged as difficult, especially in combination with the presence of psychiatric symptoms. Clients acquired an improved awareness of different aspects related to lifestyle behaviour. Irrespective of weight loss achieved, clients found their efforts successful with relatively ‘small’ changes. Some needed more support during the intervention than others. The practical activities in group sessions were regarded as most useful. HCPs were enthusiastic about the programme and their interactions with lifestyle improvements.

Conclusions
The results of this study shed light on different aspects that were considered important when delivering a lifestyle intervention to people with SMI. We recommend considering these aspects when implementing a lifestyle intervention in a mental health care setting for clients with SMI.
Risk of peripheral artery occlusive disease in patients with lower leg fracture who received fixation and non-fixation treatments: A population cohort study
Authors: Shih Pin-Keng , Chen Jian-Xun , Lin Mei-Chen , Wu Shih-Chi 
Published: August 2022

Background
The risk of peripheral artery occlusive disease (PAOD) in patients with lower leg fracture who underwent fixation procedures is not yet completely understood. Therefore, the current study aimed to examine the risk of subsequent PAOD in patients with lower leg fracture who received fixation and non-fixation treatments.

Methods
We included 6538 patients with lower leg fracture who received non-fixation treatment and a matched cohort comprising 26152 patients who received fixation treatment from the National Health Insurance Database. Patients were frequency matched according to age, sex, and index year. The incidence and risk of PAOD in patients with lower leg fracture who received fixation and non-fixation treatments were evaluated via the stratification of different characteristics and comorbidities.

Results
Non-fixation treatment, male sex, older age (≥ 50 years old), diabetes mellitus, and gout were associated with a significantly higher risk of lower extremity PAOD compare to each comparison group, respectively. Moreover, there was a significant correlation between fixation treatment and a lower risk of lower extremity PAOD in women (adjusted hazard ratio [aHR] = 0.58, 95% confidence interval [CI] = 0.38–0.90), women aged > 50 years (aHR = 0.61, 95% CI = 0.38–0.96), and patients with coronary artery disease (aHR = 0.43, 95% CI = (0.23–0.81). Further, patients with fixation treatment had a significantly lower risk of lower extremity PAOD within 2 years after trauma (aHR = 0.57, 95% CI = 0.34–0.97). The Kaplan–Meier analysis showed that the cumulative incidence of PAOD was significantly higher in the non-fixation treatment group than in the fixation treatment group at the end of the 10-year follow-up period (log-rank test: P = 0.022).

Conclusion
Patients with lower leg fracture who received non-fixation treatment had a significantly higher risk of PAOD than those who received fixation treatment. Moreover, the risk of PAOD was higher in women aged > 50 years, as well as in coronary artery disease patients who received non-fixation treatment than in those who received fixation treatment. Therefore, regular assessment of vessel patency are recommended for these patients. Nevertheless, further studies must be conducted to validate the results of our study.
Impact of pre-treatment prognostic nutritional index and the haemoglobin, albumin, lymphocyte and platelet (HALP) score on endometrial cancer survival: A prospective database analysis
Authors: Njoku Kelechi , Barr Chloe E. , Ramchander Neal C. , Crosbie Emma J. 
Published: August 2022

Purpose
The Onodera’s prognostic nutritional index (PNI) and the haemoglobin, albumin, lymphocyte and platelet (HALP) score are immune-nutritional indices that correlate with survival outcomes in several adult solid malignancies. The aim of this study was to investigate whether PNI and HALP are associated with survival outcomes in endometrial cancer.

Patients and methods
Women undergoing management for endometrial cancer were recruited to a single centre prospective cohort study. Pre-treatment PNI and HALP scores were computed for study participants and analysed as continuous variables and by selecting cut-off values based on previous publications. Both parameters were analysed in relation to overall, endometrial cancer-specific and recurrence-free survival using Kaplan-Meier estimation and multivariable Cox proportional regression.

Results
A total of 439 women, with a median age of 67 years (interquartile range (IQR), 58, 74) and BMI of 31kg/m2 (IQR 26, 37) were included in the analysis. Most had low-grade (63.3%), early-stage (84.4% stage I/II) endometrial cancer of endometrioid histological subtype (72.7%). Primary treatment was surgery in 98.2% of cases. Adjusted overall mortality hazard ratios for PNI and HALP as continuous variables were 0.97(95%CI 0.94–1.00, p = 0.136) and 0.99(95%CI 0.98–1.01, p = 0.368), respectively. Women with pre-treatment PNI ≥45 had a 45% decrease in both overall (adjusted HR = 0.55, 95% CI 0.33–0.92, p = 0.022) and cancer-specific mortality risk (adjusted HR = 0.55, 95%CI 0.30–0.99, p = 0.048) compared to those with PNI <45. There was no evidence for an effect of PNI on recurrence free survival. HALP scores were associated with adverse clinico-pathologic factors, but not overall, cancer-specific or recurrence-free survival in the multivariable analysis.

Conclusion
PNI is an independent prognostic factor in endometrial cancer and has the potential to refine pre-operative risk assessment.
Usefulness of the delta neutrophil index in predicting surgery in patients with foot and ankle infection
Authors: Shin Ji eun , Deok Seo Kyung , Cha Hyun Jae , Lee Jong Wook , Heo Youn Moo , Kim Kwang Kyoun , Kim Tae Gyun , Kang Chan , Lee Gi Soo , Song Jae Hwang 
Published: August 2022

Background
In foot and ankle infections, cases with apparent soft-tissue necrosis or purulent fluid collections definitely require surgical treatments. However, clinicians often have difficulty in determining whether to perform surgery in ambiguous cases without these findings. This study aimed to investigate the impact of the delta neutrophil index as a predictor of surgical treatment in patients with foot and ankle infections.

Methods
In total, 66 patients diagnosed with foot and ankle infections who underwent the delta neutrophil index test were retrospectively investigated. Medical records, including data on diabetes mellitus status, delta neutrophil index values, white blood cell count, polymorphonuclear leukocyte count, erythrocyte sedimentation rate, and C-reactive protein level, were retrospectively investigated. Logistic regression models were analyzed for the correlation between biomarkers, such as the delta neutrophil index and surgical treatment. The area under the curve was investigated to evaluate the cut-off value of the logistic model in predicting surgery.

Results
The relationship between the delta neutrophil index and surgical treatment was analyzed. The delta neutrophil index, adjusted for diabetes mellitus, was the best predictor of future surgical intervention. Based on the Youden index, the cutoff point (the equation’s adjusted by diabetes mellitus) for the prediction of surgical treatment was defined as a probability of 0.3, with sensitivity and specificity of 82.4% and 77.6%, respectively.

Conclusions
Based on the present study, the delta neutrophil index can help clinicians decide the appropriate surgical treatment for foot and ankle infections at the right time.
Saúde mental de policiais militares do Nordeste brasileiro: Uma revisão integrativa de literatura / Mental health of military police officers in Northeast Brazil: An integrative literature review
Authors: Lima Taynara Kelle de Menezes , Nogueira Clarissa De Pontes Vieira 
Published: August 2022

Resumo: O presente trabalho trata-se de uma revisão integrativa que objetivou apontar o que a literatura científica discorre acerca da saúde mental de policiais militares do Nordeste brasileiro. A busca de materiais foi realizada em duas importantes plataformas científicas do país: Biblioteca Digital Brasileira de Teses e Dissertações (BDTD) e Periódicos CAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior. Foram empregados para a pesquisa os termos: “Policia”; “Militares” e “Saúde Mental”. Após aplicação dos critérios de seleção, foram incluídos e analisados 9 estudos. Foram elaborados e discutidos os seguintes tópicos de categorização dos principais resultados encontrados: estresse e burnout; relação entre saúde mental e exercícios físicos; percepção de si e do contexto de trabalho; e questões de gênero. Observou-se que a maioria dos trabalhos apontaram a necessidade de realização de mais estudos com policiais, visando a fomentação de políticas e ações em benefício da saúde/saúde mental desses profissionais.Palavras-chaves: Saúde Mental; Policiais Militares; Nordeste. Abstract: The present work is an integrative review that aimed to point out what the scientific literature says about the mental health of military police in the Brazilian Northeast. The search for materials was carried out in two important scientific platforms in the country: Brazilian Digital Library of Theses and Dissertations (BDTD) and CAPES Periodicals - Coordination for the Improvement of Higher Education Personnel. The following terms were used for the research: “Police”; “Military” and “Mental Health”. After applying the selection criteria, 9 studies were included and analyzed. The following topics for categorizing the main results found were elaborated and discussed: stress and burnout; relationship between mental health and physical exercise; self-perception and the work context; and gender issues. It was observed that most of the works pointed to the need to carry out more studies with police officers, aiming at promoting policies and actions for the benefit of these professionals' mental health/health.Keywords: Mental Health; Military Police; North East.
Uma Revisão Crítica da Abrasividade em Cremes Dentais Convencionais e Clareadores / A Critical Review of Abrasiveness in Conventional Toothpastes and Whitening
Authors: Maia Maria Mariana Martins , Silva Bianca Fernandes , Andrade Bruno Vidal , Hora Taniele Andrade Teixeira da , Soares Ana Flávia 
Published: August 2022

Resumo: A presença de agentes abrasivos nos dentifrícios se torna necessária para promover uma limpeza eficaz da superfície dentária. Essa revisão de literatura visa comparar o grau de abrasividade entre dentifrícios convencionais e clareadores, verificando correlação entre a quantidade e o tipo de abrasivo. Realizou-se uma revisão bibliográfica de estudos publicados nos últimos sete anos (2016-2022), por meio de busca nas bases de dados: PubMED (National Library of Medicine) e BVS (Biblioteca Virtual em Saúde). Após a exclusão, foram encontrados 10 artigos, os quais focavam na abrasividade dos dentifrícios. A partir desses artigos, pode-se notar que o tipo, concentração e dureza influenciam diretamente no grau de desgaste, assim como o flúor tem um papel fundamental para minimizar o desgaste. Com isso, pode-se concluir que, de modo geral, os dentifrícios clareadores são mais abrasivos que os convencionais.Palavras-chave: Dentifrícios; Abrasão Dentária; Clareamento Dental. Abstract:The presence of abrasive agents in dentifrices is necessary to promote effective cleaning of the tooth surface. This literature review aims to compare the degree of abrasiveness between conventional and whitening toothpastes, verifying a correlation between the amount and type of abrasive. A literature review of studies published in the last seven years (2016-2022) was carried out through a search in the following databases: PubMED (National Library of Medicine) and VHL (Virtual Health Library). After exclusion, 10 articles were found, which focused on the abrasiveness of toothpastes. From these articles, it can be noted that the type, concentration and hardness directly influence the degree of wear, just as fluorine plays a key role in minimizing wear. With this, it can be concluded that, in general, whitening dentifrices are more abrasive than conventional ones.Keywords: Toothpaste; Dental Abrasion; Tooth whitening.
Videoconsejos “Tu Farmacéutico Informa” en Youtube: análisis de eficacia e impacto en la educación sanitaria de los internautas
Authors: Jardón Vassallo Carlos 
Published: August 2022

El Doctor Google es un fenómeno habitual en nuestro día a día. Antes de ir a la consulta con el médico/farmacéutico o después de ella acudimos a Internet para buscar información relacionada con nuestra salud y con los términos que nos ha comentado el profesional sanitario.
La búsqueda de información sanitaria on line es una práctica que realizó el 67% de los españoles entre 16 y 74 años en 2020, según datos de la Oficina de Estadística de la Unión Europea – Eurostat. Un porcentaje de búsqueda que se sitúa por encima de la media europea y que permanece en crecimiento desde el año 2017 en que se situaba en el 57% de los españoles.