bluuebunny/crossref_metadata_2025_split huggingface dataset:
Neurological complications following pediatric allogeneic hematopoietic stem cell transplantation: Risk factors and outcome
Authors: Zaidman Irina , Shaziri Tamar , Averbuch Dina , Even-Or Ehud , Dinur-Schejter Yael , NaserEddin Adeeb , Brooks Rebecca , Shadur Bella , Gefen Aharon , Stepensky Polina 
Published: December 2022

BackgroundAllogeneic hematopoietic stem cell transplantation (HSCT) is an efficient treatment for numerous malignant and nonmalignant conditions affecting children. This procedure can result in infectious and noninfectious neurological complications (NCs).ObjectiveThe objective of the study is to examine the incidence, risk factors, and outcomes of NCs in pediatric patients following allogeneic HSCT.MethodsWe performed a retrospective study of 746 children who underwent 943 allogeneic HSCTs in two large pediatric hospitals in Israel from January 2000 to December 2019.ResultsOf the pediatric patients 107 (14.3%) experienced 150 NCs. The median follow-up was 55 months. Noninfectious NCs were more common than infectious NCs (81.3% vs. 18.7%). Factors significantly associated with type of NC (infectious vs. noninfectious) were underlying disease (immunodeficiency vs. malignant and metabolic/hematologic disease) (p-value = 0.000), and use of immunosuppressive agent, either Campath or ATG (p-value = 0.041). Factors with a significant impact on developing neurological sequelae post-NC were number of HSCT &gt;1 (p-value = 0.028), the use of alemtuzumab as an immunosuppressive agent (p-value = 0.003), and infectious type of NC (p-value = 0.046). The overall survival rate of whole NC-cohort was 44%; one-third of all mortality cases were attributed to the NC. The strongest prognostic factors associated with mortality were older age at HSCT (p-value = 0.000), the use of alemtuzumab as an immunosuppressive agent (p-value = 0.004), and the existence of neurological sequelae (p-value = 0.000). Abnormal central nervous system imaging (p-value = 0.013), the use of alemtuzumab as an immunosuppressive agent (p-value = 0.019), and neurological sequelae (p-value = 0.000) had statistically significant effects on neurological cause of death.ConclusionInfectious and noninfectious NCs are a significant cause of morbidity and mortality following allogeneic HSCT in children. Further research is required to better understand the risk factors for different NCs and their outcomes regarding sequelae and survival.
Predictive value of PD-L1 expression to the efficacy of immune checkpoint inhibitors in advanced triple-negative breast cancer: A systematic review and meta-analysis
Authors: Qi Yingjie , Yan Xin , Wang Chao , Cao Hui , Liu Guangxuan 
Published: December 2022

Background: Immune checkpoint inhibitors (ICIs) have been an emerging treatment strategy for advanced triple-negative breast cancer (TNBC). Some studies have shown that high expression of programmed death-ligand 1 (PD-L1) can achieve a better response of clinical efficacy. However, the efficacy of ICIs in advanced TNBC remains controversial. In this meta-analysis, we evaluated the correlation of PD-L1 expression with the efficacy of ICIs in patients with advanced TNBC.Methods: We conducted a systematic search using four databases until March 2022 to obtain eligible randomized controlled trials (RCTs). The quality of the studies was assessed by the Cochrane risk of bias tool. Hazard ratio (HR) was extracted to evaluate the relationship between PD-L1 expression and progression-free survival (PFS) or overall survival (OS) in patients with advanced TNBC.Results: Five randomized controlled clinical trials (RCTs) with 3104 patients were included in this meta-analysis. The results demonstrated that ICIs could significantly improve the OS (HR 0.77, 95% CI 0.60–0.98, p = 0.03) in PD-L1 positive TNBC group. In the subgroup analysis, longer OS was observed (HR: 0.70, 95% CI: 0.60–0.82, p = 0.00001) in PD-L1 positive TNBC patients receiving ICIs alone or ICIs combined with nab-paclitaxel. In terms of PFS, PFS was significantly improved (HR: 0.68, 95% CI: 0.58–0.79, p &lt; 0.00001) in PD-L1 positive patients receiving first-line ICIs and chemotherapy compared to those with ICIs alone. No significant improvement was observed for OS or PFS in PD-L1 negative group.Conclusion: Our study indicated significant improvement for OS in advanced TNBC with ICIs therapy in the PD-L1 positive status, and ICIs alone or ICIs combined with nab-paclitaxel might be a excellent choice in terms of OS. Although PFS has no significant benefit in PD-L1 positive patients, the subgroup analysis showed that ICIs combined with chemotherapy could achieve the PFS benefit in the first-line treatment. However, further clinical studies are needed to validate our conclusions due to limited relevant research.
Spermidine exogenous application mollifies reproductive stage heat stress ramifications in rice
Authors: Karwa Sourabh , Taunk Jyoti , Maurya Sadhana , Das Adhip , Krishna G. K. , Arya Sunder Singh , Kumar Awadhesh , Kumar Sudhir , Kumar Pramod , Chinnusamy Viswanathan , Pal Madan 
Published: December 2022

IntroductionRice productivity is severely hampered by heat stress (HS) which induces oxidative stress in this crop. This oxidative stress can be alleviated using various exogenous chemicals, including spermidine (Spd). Therefore, the present study was carried out to characterize HS components and to elucidate the role of exogenous Spd application in rice at the flowering stage.MethodsTwo contrasting rice genotypes, i.e. Nagina22 (N22) and Pusa Basmati-1121 (PB-1121) were placed in temperature tunnels and exposed to HS (38–43°C) with and without Spd (1.5 mM) foliar application during the heading stage till the end of the anthesis stage.ResultHeat stress induced the production of H2O2and thiobarbituric acid reactive substances, which resulted in lower photosynthesis, spikelet sterility, and reduced grain yield. Interestingly, foliar application of Spd induced antioxidant enzyme activities and thus increased total antioxidant capacity resulting in higher photosynthesis, spikelet fertility, and improved grain yield under HS in both genotypes. Under HS with Spd, higher sugar content was recorded as compared to HS alone, which maintained the osmotic equilibrium in leaf and spikelets. Spd application initiatedin vivopolyamine biosynthesis, which increased endogenous polyamine levels.DiscussionThis study corroborates that the exogenous application of Spd is promising in induction of antioxidant defence and ameliorating HS tolerance in riceviaimproved photosynthesis and transpiration. Thereby, the study proposes the potential application of Spd to reduce HS in rice under current global warming scenario.
Negative workplace gossip and turnover intention among Chinese rural preschool teachers: The mediation of ego depletion and the moderation of bianzhi
Authors: He Can , Wei Hua 
Published: December 2022

IntroductionIn China, the high turnover rates of teachers have become one of the biggest obstacles to the development of rural preschool education. Objective: Based on the social information processing theory and the strength model of selfcontrol, this study examined the relationship between negative workplace gossip and turnover intention and the role of ego depletion and bianzhi in this relationship.MethodsThe questionnaire method was applied, and 411 rural preschool teachers in Hubei Province, China, participated in the survey.ResultsThe correlation results showed that negative workplace gossip was positively correlated with ego depletion, and ego depletion was positively correlated with turnover intention. After controlling for age, negative workplace gossip positively predicted turnover intention. The mediation analysis indicated that ego depletion played a mediating role in the relationship between negative workplace gossip and turnover intention. Moreover, the mediation effect was moderated by bianzhi. Negative workplace gossip had a stronger effect on the ego depletion of teachers without bianzhi than on that of teachers with bianzhi.ConclusionThe current research is the first to clarify that ego depletion mediates the relationship between negative workplace gossip and turnover intention, and the mediation effect is moderated via bianzhi. These findings expand our understanding of the influential factors and formation mechanisms of turnover intention. In practice, this study provides a novel perspective for policymakers and administrators to reduce the turnover intention among rural preschool teachers in China.
Investigation of the effect of flipped listening instruction on the listening performance and listening anxiety of Chinese EFL students
Authors: Qiu Yu , Luo Wei 
Published: December 2022

IntroductionGiven the fact that flipped instruction especially with the aid of technology has gained momentum in second language (L2) instruction, numerous L2 researchers have explored the usefulness of flipped classroom for L2 learning.MethodsAs an attempt to further this research area, the current research examined the effect of flipped listening instruction on the Chinese English as a foreign language (EFL) students’ listening performance and listening anxiety using a quasi-experimental research design. To this end, a total number of 44 EFL learners from two intact classes in a Chinese language school were selected as the participants of the research and they were randomly assigned as the control group (N = 21) and an experimental group (N = 23). Within a course of one semester, the control group was instructed employing traditional listening instruction, while the experimental group were taught based on the flipped mode of instruction.ResultsThe data collection was carried out by administering the listening section of IELTS and Foreign Language Listening Anxiety Scale (FLLAS).DiscussionThe results of ANCOVA revealed that the flipped listening instruction significantly enhanced listening performance of the participants. Also, the flipped classroom substantially reduced listening anxiety of the EFL learners. The outcomes of this research might provide notable implications for EFL practitioners.
Association of prescribed oral stimulants on cocaine use among patients enrolled in opioid agonist treatment: A retrospective longitudinal cohort study
Authors: Tatangelo Mark , Tahsin Farah , Morin Kristen A. , Marsh David C. 
Published: December 2022

ObjectivesThe objective of this study was to measure the association of prescribed oral stimulants with the consumption of cocaine among a population of patients receiving Opioid Agonist Therapy (OAT).MethodsThe study was a retrospective clinical cohort study using the medical records of all patients receiving OAT who attended treatment clinics within the Canadian Addiction Treatment Centers (CATC) in Ontario from April 2014 to February 2021. Linear mixed-effects models were fit for the exposure of prescribed oral stimulants, and the outcome of a positive urinalysis drug screen for cocaine. Covariates for age, sex, and a random effect for patients were fitted to account for differences between and within patient observations over time.ResultsAmong patients receiving OAT therapyn= 314 patients were prescribed oral stimulants andn= 11,879 patients were not prescribed oral stimulants among Ontario CATC clinics (n= 92,n= 145 physicians), the mean age at enrollment for patients receiving oral stimulants was 37.0,SD= 8.8, with 43.6% female patients and for patients not receiving oral stimulants mean age was 36.6,SD= 10.7, with 39.6% female patients. Linear mixed effects models showed no difference in cocaine-positive urine tests over time for fixed effectsB= 0.001, however, when considering the Interclass correlation coefficient (ICC) between the fixed effects, we found that time since the prescription of an oral stimulant was associated with a decrease of ICC = −0.14 in cocaine positive urine tests. Increasing age at prescription ICC = −0.92, and being male ICC = −0.23 were associated with decreasing cocaine-positive urine.ConclusionThe use of oral stimulant prescriptions to treat cocaine use had no clinically significant benefit in a real-world setting. Patients who receive prescriptions for oral stimulants consume more cocaine before and after treatment compared to patients without an oral stimulant prescription. We also observed that cocaine use was reduced with increased time since treatment initiation.
Food safety knowledge, needed and trusted information of pork consumers in different retail types in Northern Vietnam
Authors: Le Trang Thi-Huyen , Langley Shonara Jayde , Dunham Jordan Gibson , Dang-Xuan Sinh , Unger Fred , Ngo Hai Hoang Tuan , Nguyen-Thanh Luong , Nguyen-Viet Hung , Toribio Jenny-Ann 
Published: December 2022

IntroductionFood safety is an important public health concern globally. Risk communication is one of crucial element to manage food safety. While current food safety studies have focused on contamination of hazards or risk factors, limited research exists on consumer concerns, knowledge and perception about the actual risk food poses to their health. This study aimed to assess and compare the knowledge and perceptions regarding food safety, and the information needed and trusted by pork consumers in Northern Vietnam.MethodsA total of 225 consumers recruited from three different market types: modern urban, traditional urban and traditional rural, were interviewed using a questionnaire between November to December 2019.ResultsThe majority of participants (81.8%) were female and consumers interviewed at modern urban retail were younger than those interviewed at traditional retail settings (p &lt; 0.01). Sixty-five percent of participants across the three retail types agreed that microbes were the most common hazards which can make them sick, but the adverse health effect due to chemical hazards was ranked higher than that of biological hazards. Most participants often received food safety information that was about animal diseases (such as African swine fever most recently), chemical contamination and the unknown origin of food rather than about food poisoning and measures to prevent it. Food safety messages from television and professional experts were the most trusted sources and consumer preference was for information about the origin of food (traceability) and how to choose safe food. Participants were willing to receive food safety information daily to weekly. A lack of perception and awareness about animal welfare related to pig farming or slaughtering was reported by most respondents (84.3%).DiscussionThese findings provide insight on Vietnamese consumer knowledge gaps, information demand and communication channels for food safety, so that risk communicators and managers can implement better food safety awareness campaigns and communication to consumers.
Larvicidal Effect of Hyptis suaveolens (L.) Poit. Essential Oil Nanoemulsion on Culex quinquefasciatus (Diptera: Culicidae)
Authors: Peniche Taires , Duarte Jonatas L. , Ferreira Ricardo M. A. , Sidônio Igor A. P. , Sarquis Rosângela S. F. R. , Sarquis Ícaro R. , Oliveira Anna E. M. F. M. , Cruz Rodrigo A. S. , Ferreira Irlon M. , Florentino Alexandro C. , Carvalho José C. T. , Souto Raimundo N. P. , Fernandes Caio P. 
Published: December 2022

Mosquitoes can be vectors of pathogens and transmit diseases to both animals and humans. Species of the genus Culex are part of the cycle of neglected diseases, especially Culex quinquefasciatus, which is an anthropophilic vector of lymphatic filariasis. Natural products can be an alternative to synthetic insecticides for vector control; however, the main issue is the poor water availability of some compounds from plant origin. In this context, nanoemulsions are kinetic stable delivery systems of great interest for lipophilic substances. The objective of this study was to investigate the larvicidal activity of the Hyptis suaveolens essential oil nanoemulsion on Cx. quinquefasciatus. The essential oil showed a predominance of monoterpenes with retention time (RT) lower than 15 min. The average size diameter of the emulsions (sorbitan monooleate/polysorbate 20) was ≤ 200 nm. The nanoemulsion showed high larvicidal activity in concentrations of 250 and 125 ppm. CL50 values were 102.41 (77.5253–149.14) ppm and 70.8105 (44.5282–109.811) ppm after 24 and 48 h, respectively. The mortality rate in the surfactant control was lower than 9%. Scanning micrograph images showed changes in the larvae’s integument. This study achieved an active nanoemulsion on Cx. quinquefasciatus through a low-energy-input technique and without using potentially toxic organic solvents. Therefore, it expands the scope of possible applications of H. suaveolens essential oil in the production of high-added-value nanosystems for tropical disease vector control.
Contextualizing Lecturer Performance Indicators to Online Teaching and Learning Activities: Insights for Application during the COVID-19 Pandemic And Beyond
Authors: Maulana Amalia E. , Arli Denni 
Published: December 2022

The purpose of this research study is to explore insights to create more contextual lecturer performance indicators (LPIs); and to gain a fairer and more useful evaluation tool for lecturers in the online environment during the COVID-19 pandemic. This significant change in conditions has forced higher education to understand the new requirements, especially of lecturers, who have played a central role in creating engaging moments for students in online classes. This study adopts a qualitative approach, based on the need for a more in-depth exploration of new phenomena. It explores students’ daily lives in class, which were expressed through social media, and gains further understanding through in-depth interviews with students and lecturers. The results indicate that most of the items taken from the Social-Task-Technology-Fit (STTF) framework remain the same; there are not many changes compared to the era before the pandemic. However, some aspects have new meanings that need to be revisited to capture the lecturers' performance in the new context. Three new themes emerged from the exploration study which have never been discussed in previous studies on LPIs for online teaching, especially in abnormal conditions such as a pandemic. The first theme concerns the variations in digital literacy of lecturers and the implications for lecturers' performance. The second theme is the dynamic ratio of social versus task activities, which implies the need to focus on academic (task-oriented) or non-academic (social) tasks. The third theme is the degree of controllability of each performance. This study provides awareness of the importance of weighting in evaluating lecturer performance, especially when not all lecturers are digitally literate, not all factors are controllable, and the ratios between social versus task requirements are not the same. These weighted evaluations have never been discussed in previous studies, which mainly used quantitative surveys. In addition, these insights can also be applied to online learning beyond the pandemic. The study results can be used by higher education information management to design more contextual LPIs for the early detection of issues with lecturer performance.
PENGARUH PEMBERIAN PUPUK NPK-DGW COMPACTION YANG DIBUDIDAYA PADA JENIS TANAH YANG BERBEDA TERHADAP PERTUMBUHAN DAN PRODUKSI TANAMAN TOMAT (Lycopersicum esculentum Mill)
Authors: Haeba Haeba , Nurdin Dahlia , Makmur Makmur 
Published: December 2022

Produksi dan produktifitas tomat tiap tahunnya masih fluktuatif tahun lalu produksinya mengalami peningkatan kembali yaitu dari 635.475ton menjadi 725.973ton, hal ini terjadi karena sebabkan oleh teknik budidaya yang belum di kelolah secara baik, sebagai solusi penggunaan pupuk majemuk berupa NPKdengan jenis tanah yang berbeda yang diharapkan mampu meningkatkan produksi tanaman tomat adapun penelitian ini dilaksanakan di Desa Lombong Timur, Kecamatan Malunda, yang berlangsung dari bulan Juli 2019 sampai dengan bulan September 2019. Penelitian (RAK) yang terdiri dari 2 (dua) faktor yaitu: pemberian berbagai jenis tanah yang terdiri dari 3 jenis yaitu : Tanah humus, Tanah aluvial, dan Tanah berpasir. Faktor kedua pemberian pupuk NPK-DGW Compaction yaitu: tanpa pemberian, 2 gr/tanaman, dan 4 gr/tanaman. Hasil penelitian sebagai berikut: interaksi antara pemberian pupuk NPK DGW Compaction dan berbagai jenis tanah tidak memberikan pengaruh baik pada tinggi tanaman, jumlah daun, jumlah cabang, umur berbunga, umur panen, jumlah buah dan berat buah. Begitu pula dengan pemberian pupuk NPK DGW Compaction juga tidak memberikan pengaruh baik pada tinggi tanaman, jumlah daun, jumlah cabang, umur berbunga, umur panen, jumlah buah dan berat buah. Tetapi pemberian jenis tanah humus memberikan pengaruh baik pada tinggi tanaman, jumlah daun, jumlah cabang, umur berbunga, umur panen, jumlahbuah dan berat buah.
First-principles study for self-limiting growth of GaN layers on AlN(0001) surface
Authors: Sokudo Haruka , Akiyama Toru , Ito Tomonori 
Published: December 2022

Abstract
The GaN thickness dependence of surface structural stability and adsorption behavior of Ga adatom in GaN layers on a AlN(0001) surface are investigated on the basis of first-principles calculations to clarify the self-limiting growth on AlN(0001) surface during metal-organic vapor phase epitaxy. The calculations demonstrate that the stability of reconstructed GaN layers on a AlN(0001) surface is similar to that of a GaN(0001) surface irrespective of the GaN film thickness. Furthermore, we find that the adsorption of a Ga adatom on the AlN(0001) surface easily occurs compared with that on AlN(0001) surface with GaN layers. The difference in the adsorption behavior implies that the growth of GaN layers on a AlN(0001) surface is suppressed. The calculated results provide theoretical guidance for understanding the self-limiting growth of GaN layers, resulting in the formation mechanism of GaN quantum wells.
Analysis of 1.2 kV GaN polarisation superjunction diode surge current capability
Authors: Sheikhan Alireza , Narayanankutty Gopika , Narayanan E. M. Sankara , Kawai Hiroji , Yagi Shuichi , Narui Hironobu 
Published: December 2022

Abstract
The surge current capability of power diodes is one of the essential parameters that needs to be considered for high power density operations in power electronic applications. Gallium Nitride (GaN) is emerging as the next generation of power semiconductor devices due to its superior material characteristics. This work presents the device working principle, characteristics, and the surge capability of 1200 V GaN polarisation superjunction (PSJ) hybrid diodes. The experimental results show that the GaN PSJ diode can withstand a surge current of 60 A which is around 8 times its rated current and a surge energy of 5.4 J. Additionally, despite having a merged PiN and Schottky structure, no bipolar current flow due to the activation of p-doped GaN can be observed until breakdown. This can also be confirmed through the device forward characteristic which shows a unique saturation behaviour at about 76 A without any bipolar region.