bluuebunny/crossref_metadata_2025_split huggingface dataset:
Equine papillomavirus type 2‐associated, carcinomatous lesions of the penis and laryngopharynx of an elderly Icelandic horse gelding
Authors: Lale Dilara , Geyer Antonia , Jindra Christoph , Cavalleri Jessika‐Maximiliane V. , Ramsauer Anna Sophie 
Published: October 2022

AbstractA 28‐year‐old Icelandic horse gelding was presented with a laryngopharyngeal squamous cell carcinoma. The gelding had been treated for penile carcinoma in situ with a partial phallectomy 2 years earlier. Polymerase chain reaction of tumour DNA and subsequent amplicon sequencing revealed that the equine papillomavirus type 2 E6 oncogene sequences of both lesions were identical. There is strong evidence that equine papillomavirus type 2 is causally associated with genital squamous cell carcinomas and precancerous lesions. Recent reports indicate that equine papillomavirus type 2 might also play an active role in the pathogenesis of approximately 20% of equine squamous cell carcinomas in the oronasal, pharyngeal and laryngeal regions. To the authors’ knowledge, this is the first report of a horse consecutively developing a penile carcinoma in situ and a laryngopharyngeal squamous cell carcinoma that were apparently induced by the same equine papillomavirus type 2 variant. Possible equine papillomavirus type 2 infection pathways in this horse and the importance of early detection of lesions are discussed in this context.
Higher-spin gravity’s “string”: new gauge and proof of holographic duality for the linearized Didenko-Vasiliev solution
Authors: Lysov Vyacheslav , Neiman Yasha 
Published: October 2022

Abstract
We consider type-A higher-spin gravity in AdS4, holographically dual to a free U(N ) vector model on the boundary. We study the linearized version of the Didenko-Vasiliev “BPS black hole”, which we view as this theory’s equivalent of the fundamental string. The Didenko-Vasiliev solution consists of gauge fields of all spins generated by a particle-like source along a bulk geodesic, and is holographically dual to a bilocal boundary operator at the geodesic’s endpoints. Our first main result is a new gauge for this solution, which makes manifest its behavior under the boundary field equation. It can be viewed as an AdS uplift of flat spacetime’s de Donder gauge, but is not de Donder in AdS. To our knowledge, this gauge is novel even in the spin-2 sector, and thus provides a new expression for the linearized gravitational field of a massive point particle in (A)dS4. Our second main result is a proof of the holographic duality between the mutual bulk action of two Didenko-Vasiliev solutions and the CFT correlator of two boundary bilocals. As an intermediate step, we show that in a bilocal→local limit, the Didenko-Vasiliev solution reproduces the standard boundary-bulk propagators of all spins. We work in the “metric-like” language of Fronsdal fields, and use the embedding-space formalism.
Flavored anisotropic black holes
Authors: Garbayo Ana , Hoyos Carlos , Jokela Niko , Penín José Manuel , Ramallo Alfonso V. 
Published: October 2022

Abstract
We construct a black hole geometry dual to a (2+1)-dimensional defect in an ambient (3+1)-dimensional gauge theory at non-zero temperature and quark density. The geometry is a solution to the equations of motion of type IIB supergravity with brane sources, a low energy limit of an intersection of stacks of color D3-branes and flavor D5-branes. We consider the case in which the number of D5-branes is large and they can be homogeneously distributed along the directions orthogonal to the defect, creating in this way a multilayer structure. The quark density is generated by exciting a gauge field in the worldvolume of the dynamic brane sources. We study the thermodynamics of the anisotropic black hole and compute the energy density of the dual theory, as well as the pressures and speeds of sound along the directions parallel and orthogonal to the defect. We also calculate transport coefficients in the shear channel, quark-antiquark potentials, and the entanglement entropies for slab subregions. These analyses give us a good overview on how the degrees of freedom are spread, entangled, and behave in this unquenched system in the deconfining phase at strong coupling.
Magnetic and structure transition of Mn3-xFexO4 solid solutions under high-pressure and high-temperature conditions
Authors: Yamanaka Takamitsu , Hirao Naohisa , Nakamoto Yuki , Mikouchi Takashi , Hattori Takanori , Komatsu Kazuki , Mao Ho-kwang 
Published: October 2022

AbstractMagnetic and structure transitions of Mn3–xFexO4 solid solutions under extreme conditions are clarified by neutron time-of-flight scattering diffraction and X-ray Mössbauer measurement. The ferrimagnetic-to-paramagnetic transition temperature (100 °C) of Mn2FeO4 spinel is different from the tetragonal-to-cubic structure transition temperature (180 °C). The structure transition temperature decreases with increasing pressure. The transition is not coupled with the magnetic transition. Synchrotron X-ray Mössbauer experiments have revealed the pressure effects on the distribution of Fe2+ and Fe3+ at the tetrahedral and octahedral sites in the spinel structure. Ferrimagnetic MnFe2O4 and Mn2FeO4 spinels show sextet spectral features with hyperfine structure elicited by internal magnetic fields. Cubic MnFe2O4 spinel and tetragonal Mn2FeO4 transform to high-pressure orthorhombic postspinel phase above pressures of 18.4 GPa and 14.0 GPa, respectively. The transition pressure decreases with increasing Mn content. The postspinel phase has a paramagnetic property. Mn2O10 dimers of two octahedra are linked via common edge in three dimentional direction. The occupancy of Fe2+ in the tatrahedral site is decreased with increasig pressure, indicating more oredered structure. Consequently, the inverse parameter of the spinel structure is increased with increasing pressure. The magnetic structure refinements clarify the paramagnetic and ferrimagnetic structure of MnFe2O4 and Mn2FeO4 spinel as a function of pressure. The magnetic moment is ordered between A and B sites with the anti-parallel distribution along the b axis. The nuclear tetragonal structure (aN, aN, cN) has the ferrimagnetic structure but the orthorhombic magnetic structure has the ferrimagnetic structure with the lattice constants (aM, bM, cM). The magnetic moment is ordered between A and B sites with the anti-parallel distribution along the bM axis.
The mechanisms of the subseasonal zonal oscillation of the western Pacific subtropical high in 10–25-day period and 25–50-day period
Authors: Nie Jun , Fang Jiabei , Yang Xiu-Qun 
Published: October 2022

AbstractThis study investigates the evolution characteristics and the mechanism, including the convection–circulation interaction and the air–sea interaction, of the subseasonal zonal oscillation of the western Pacific subtropical high (WPSH) in 10–25-day period and 25–50-day period. Accompanied with the westward extension of the WPSH, a suppressed convection propagates northwestward over the western Pacific with an anticyclonic circulation anomaly at its northwest. A warm sea surface temperature anomaly (SSTA) lags the anomalous convection, showing near-quadrature phase relationship in temporal, and the magnitude of SSTA in 25–50-day period is greater than that in 10–25-day period. Further analysis shows that in both two periods the westward extension of the WPSH is mainly attributed to the convection–circulation interaction. The suppressed convection-induced cooling stimulates the divergence anomaly at the northwest of the suppressed convection, causing anticyclonic anomaly through the horizontal divergence effect. In turn, the anticyclonic anomaly motivates the downward dry advection in planetary boundary layer (PBL) preceding the suppressed convection, and thus favors the propagation of the suppressed convection. Through such interaction processes, the convection and circulation anomalies are combined and propagate together, leading to the zonal oscillation of the WPSH. Moreover, it is also found that the significance of air–sea interaction in two periods is distinct due to different magnitudes of the SSTA. In 10–25-day period, the ocean has no obvious feedback on the atmospheric circulation, while in 25–50-day period, the oceanic anomaly can fully develop and impact on the atmosphere more effectively.
Solving Cubic Matrix Equations Arising in Conservative Dynamics
Authors: Benzi Michele , Viviani Milo 
Published: October 2022

AbstractIn this paper we consider the spatial semi-discretization of conservative PDEs. Such finite dimensional approximations of infinite dimensional dynamical systems can be described as flows in suitable matrix spaces, which in turn leads to the need to solve polynomial matrix equations, a classical and important topic both in theoretical and in applied mathematics. Solving numerically these equations is challenging due to the presence of several conservation laws which our finite models incorporate and which must be retained while integrating the equations of motion. In the last thirty years, the theory of geometric integration has provided a variety of techniques to tackle this problem. These numerical methods require solving both direct and inverse problems in matrix spaces. We present three algorithms to solve a cubic matrix equation arising in the geometric integration of isospectral flows. This type of ODEs includes finite models of ideal hydrodynamics, plasma dynamics, and spin particles, which we use as test problems for our algorithms.
Development of irrigation schedule and management model for sustaining optimal crop production under agricultural drought
Authors: Lee Taehwa , Jang Won Seok , Chun Beomseok , Ahmad Mirza Junaid , Jung Younghun , Kim Jonggun , Shin Yongchul 
Published: October 2022

AbstractAgriculture is vulnerable to drought indicating that the increasing climate crisis requires the necessity of sustainable crop production. In this study, we developed the Irrigation Schedule and Management (ISM) model based on a simulation–optimization (Soil Water Atmosphere Plant-SWAP model with Genetic Algorithm-GA) framework. The ISM model finds an optimal combination of Irrigation Water Amount (IWA) and Irrigation Interval (II) by adjusting Water Stress (WS) responding to environmental conditions (weather, soils, crops and bottom boundary conditions) throughout growing periods. By conditioning the crop (WS) and water management (IWA and II) variables, ISM improves the sustainability of optimal crop productions under different climatic-land surface conditions. The Regional Agromet Center (RAC) site in Faisalabad (at Punjab, Pakistan) was selected to test the proposed ISM model for the field validation/synthetic numerical experiments with various crops (Wheat, Corn and Potato) and soils. We demonstrated that the ISM model that reflects the relationship between crop and water management variables improved the sustainability of crop productions and Water Productivity (WP) compared to those of the conventional irrigation method at the RAC site under various environment conditions. Additionally, the ISM-based long-term crop productions showed the variations along the yearly precipitation changes indicating that optimal combinations of the crop and water management variables are considerably influenced by environmental conditions. Although uncertainties exist, our proposed ISM model can contribute to the establishment of efficient irrigation schedule/management plans under agricultural drought.
Out-of-pocket Expenses and Time Spent on Clinic Visits Among HIV Pre-exposure Prophylaxis Users and Other Clinic Attendees in Eswatini
Authors: Kohler Stefan , Dalal Shona , Hettema Anita , Matse Sindy , Bärnighausen Till , Paul Nicolas 
Published: October 2022

AbstractUser costs constitute a barrier to the uptake of HIV pre-exposure prophylaxis (PrEP), but their magnitude appears rarely assessed. In this prospective observational study, we assessed self-reported out-of-pocket expenses (OOPE) and time spent on clinic visits during a PrEP demonstration project in Eswatini. At six public primary care clinics, 240 PrEP users and other clinic attendees were interviewed after a clinic visit. Among the 79.2% of clinic attendees reporting any medical OOPE (e.g., expenses for consultations or drugs) and/or non-medical OOPE (e.g., expenses for transport, food, or phone use), the median total OOPE was $1.36 (IQR 0.91–1.96). Non-medical OOPE occurred mostly due to transport expenses. The median travel time for a clinic visit was 1.0 h (IQR 0.67–2.0). The median time spent in the clinic was 2.0 h (IQR 1.15–3.0). The median opportunity cost of a clinic visit was $7.54 (IQR 5.42–11) when valuing time spent on a clinic visit with Eswatini’s per-capita gross domestic product. Our findings can guide measures to reduce the user costs of PrEP in Eswatini and other contexts in which oral PrEP is provided through health care facilities.
Past anthropogenic activities offset dissolved inorganic phosphorus retention in the Mississippi River basin
Authors: Vilmin Lauriane , Bouwman Alexander F. , Beusen Arthur H. W. , van Hoek Wim Joost , Mogollón José M. 
Published: October 2022

AbstractThe rapid acceleration of anthropogenic phosphorus (P) loadings to watersheds has fuelled massive freshwater and coastal eutrophication and completely changed the global P cycle. Within watersheds, emitted P is transported downstream towards estuaries. Reservoirs can retain a significant proportion of this P. In the long term, this accumulated P can however be re-mobilized, a process lacking in current global P budgets. Here, we include P cycling in a coupled integrated assessment-hydrology-biogeochemistry framework with 0.5 by 0.5-degree spatial resolution and an annual time resolution, and apply it to the Mississippi River basin (MRB). We show that, while reservoirs have aided in the net retention of P, they serve as dissolved inorganic P (DIP) sources due to the transformation of legacy P in sediments. The increasing DIP sourcing in the MRB has been offsetting P retention in streams, especially towards the end of the twentieth century. Due to its bioavailability, DIP is the most likely form to trigger eutrophication. Although P inputs into the MRB have decreased since the 1970s, legacy effects are delaying positive outcomes of remediation measures.
The analytic hierarchy process as an innovative way to enable stakeholder engagement for sustainability reporting in the food industry
Authors: D’Adamo Idiano 
Published: October 2022

AbstractThe sustainable transition, which requires a combination of natural and human resources to foster the development and protection of ecosystems, is a challenge of civil society. New approaches may be proposed to support enterprises in identifying the appropriate strategic criteria for their sustainability initiatives, which are eventually documented in corporate sustainability reports. The present paper focuses on the food industry, particularly with regard to pasta production.The analytic hierarchy process method was used to assign relevance to sustainability criteria, according to the judgment of 10 academic experts. The initial criteria were selected from the sustainability reports of a virtuous and Italian pasta producer, La Molisana S.p.A., and divided into four categories: (1) people and community, (2) innovation and new product development, (3) commitment to the environment and (4) local supply chain and traceability.
Promotion of social and economic development in the local community emerged as the most relevant criterion, followed by business development and promotion of talent. The people and community category was deemed most strategic for sustainability, while social and economic dimensions were given less relevance. Stakeholder engagement was proposed as an order winner for sustainable strategies.The present work has relevant methodological implications, as it shows that the analytic hierarchy process, applied in conjunction with a sustainability materiality matrix, may provide new and useful information for strategy and communication. In terms of operational implications, an enterprise’s historical connection to an area may attract global recognition and increase brand value through higher raw material quality, the harmonisation of human and natural resources, and synergy with the tourism industry.
Treatment of cardiac fibrosis: from neuro-hormonal inhibitors to CAR-T cell therapy
Authors: Morfino Paolo , Aimo Alberto , Castiglione Vincenzo , Gálvez-Montón Carolina , Emdin Michele , Bayes-Genis Antoni 
Published: October 2022

AbstractCardiac fibrosis is characterized by the deposition of extracellular matrix proteins in the spaces between cardiomyocytes following both acute and chronic tissue damage events, resulting in the remodeling and stiffening of heart tissue. Fibrosis plays an important role in the pathogenesis of many cardiovascular disorders, including heart failure and myocardial infarction. Several studies have identified fibroblasts, which are induced to differentiate into myofibroblasts in response to various types of damage, as the most important cell types involved in the fibrotic process. Some drugs, such as inhibitors of the renin–angiotensin–aldosterone system, have been shown to be effective in reducing cardiac fibrosis. There are currently no drugs with primarily anti-fibrotic action approved for clinical use, as well as the evidence of a clinical efficacy of these drugs is extremely limited, despite the numerous encouraging results from experimental studies. A new approach is represented by the use of CAR-T cells engineered in vivo using lipid nanoparticles containing mRNA coding for a receptor directed against the FAP protein, expressed by cardiac myofibroblasts. This strategy has proved to be safe and effective in reducing myocardial fibrosis and improving cardiac function in mouse models of cardiac fibrosis. Clinical studies are required to test this novel approach in humans.
Relationship between collaboration and normalized scientific impact in South American public universities
Authors: Limaymanta Cesar H. , Quiroz-de-García Rosalía , Rivas-Villena Jesús A. , Rojas-Arroyo Andrea , Gregorio-Chaviano Orlando 
Published: October 2022

AbstractThe relationship between international collaboration and scientific impact is studied in the context of South American universities. This study aims to comprehensively analyze the strength of this relationship using nonparametric statistical methods. The records are the 244,300 papers published in journals indexed in Scopus (2011–2020) by researchers affiliated to 10 South American public universities and extracted with Scival support. There is a marked trend of collaborative work, since 93% of publications were collaborative at institutional, national or international level, with a higher percentage of international collaboration. A refined analysis of the geographic collaboration of publications in Q1 journals further evidences the frequency of international collaboration. In the top 4 collaborating partner institutions for each university, the presence of the Centre National de la Recherche Scientifique of France (CNRS) is observed, followed by the National Council for Scientific and Technical Research of Argentina (Conicet). It is proven that there is a statistically significant relationship (p < .01) in each of the 10 universities between collaboration (number of countries) and normalized impact (FWCI). The results confirmed the hypothesis of this study and the authors provide practical recommendations for science policy makers and researchers, including the promotion of strategic collaboration between different institutional sectors of society to increase the impact of publications.
Effect of inoculation with prion dilutions within the dynamic range of ELISA absorbance on prion incubation period
Authors: Cassmann Eric D. , Brown Quazetta L. , Frese Alexis J. , Lambert Zoe J. , Greenlee M. Heather West , Greenlee Justin J. 
Published: October 2022

AbstractThis study examines the effect of various infectious prion titers within the dynamic range as measured by ELISA on incubation period. We inoculated ovinized transgenic mice with seven decreasing dilutions of a fast-incubating scrapie strain. The highest inoculum group was a 20% w/v brain homogenate from a sheep with scrapie. The subsequent six inoculum dilutions ranged from the highest ELISA optical density reading of 4.000 to a dilution where scrapie prions were not detectable by ELISA. Multiple comparison analysis demonstrated variation in the incubation periods between some inoculum groups. Incubation periods were similar between inoculum groups unless their optical density differed by more than ≈2 units of absorbance. These data will inform the interpretation of future studies that compare incubation periods in experimentally inoculated animals for TSE research.
Does seasonality affect snoring? A study based on international data from the past decade
Authors: Wang Ping , Chen Cai , Wang Xingwei , Zhang Ningling , Lv Danyang , Li Wei , Peng Fulai , Wang Xiuli 
Published: October 2022

Abstract

Background
Though snoring is often regarded as a harmless condition that coincides with sound sleep, it is a sleep disorder that can be a potential indicator of more severe conditions such as sleep apnea syndrome. In the present study, we investigated the association between seasonal variations and snoring.

Method
Search index for snoring (SIS) data were obtained from Google Trends and Baidu Index. SIS data were collected for the USA, India, Germany, Russia, Japan, Australia, China, and Brazil from 2011 to 2020, with the periodicity of the relationship between seasonal time series data and snoring evaluated using a time series decomposition model.

Result
The highest average SIS growth rates from 2011 to 2020 were observed for Brazil, Japan, and Germany, with average SIS values of 94%, 68%, and 49%, respectively. The SIS of the USA, Russia, Japan, Brazil, Australia, Germany, and India increased by 22.3%, 12.4%, 11.9%, 35.4%, 12.3%, 28.0%, and 55.8%, respectively, in comparison with their SIS values in 2019, whereas for China, it decreased by 13.7%. Relative to countries in the southern hemisphere, those in the northern hemisphere showed comparable SIS trends, increasing from September to February and decreasing from March to August.

Conclusion
The SIS data showed cyclical changes over the study period. The search index for snoring increased during the cold season or the heating season, suggesting that snoring is associated with seasonal changes.