bluuebunny/crossref_metadata_2025_split huggingface dataset:
The impacts of corrected left ventricular ejection time combined with dobutamine on hepatocellular carcinoma patients
Authors: Jian Yu , Xiaochen Ji , Zongjian Sun , Yu Nie , Shiqiang Shan 
Published: December 2022

AbstractTo evaluate the clinical effect of corrected left ventricular ejection time (LVETc) combined with dobutamine on the intraoperative management of patients undergoing hepatectomy for hepatocellular carcinoma. Sixty-eight patients with elective proposed pancreaticoduodenectomy, aged 61–78 years, body mass index 19–26 kg/m2, and ASA classification II or III, were divided into two groups (n = 34) using the random number table method: the esophageal ultrasound group (S group) and the esophageal ultrasound combined with dobutamine group (D group). In both groups, an esophageal ultrasound probe was placed after induction of anesthesia, and the left ventricular ejection time (LVET) and stroke volume (SV) were measured via a long-axis section of gastric fundus to guide fluid infusion. Nitroglycerin or a combination of dobutamine and nitroglycerine were pumped intravenously from the beginning of surgery to the completion of hemostasis after partial hepatectomy, in groups S or D, respectively. Central Venous Pressure (CVP), heart rate HR, and mean arterial pressure MAP were recorded at entry (T0), immediately after induction (T1), at the beginning of the operation (T2), during hilar occlusion (T3), after partial hepatectomy (T4), and after the operation (T5). SV and LVETc were recorded between T1 and T5. At T0 and T5, blood samples from radial artery and central vein were taken to determine the concentration of blood lactic acid, and the oxygen supply index (DO2I) and oxygen uptake rate (O2ERe) were calculated by blood gas analysis. The operation time, hilar occlusion time, intraoperative urine volume, intraoperative crystalloid and colloid infusion, intraoperative blood loss and blood transfusion, and the occurrence of cardiac gas emboli during the operation were also recorded. Adverse events of cardiovascular, pulmonary, and renal function during and after operation were registered. Sixty-four patients were included in the final analysis. Compared with group S, group D had lower CVP values at T2–T3 and higher SV values at T2–T5, reduced intraoperative blood loss, significantly increased intraoperative urine output, a smaller total dose of nitroglycerin use, and lower incidences of intraoperative hypotension and cardiac gas emboli (P < 0.05). Esophageal ultrasound detection of LVETc combined with dobutamine ensures hemodynamic stability in patients undergoing partial hepatectomy while reducing the incidence of intraoperative hypotension and air embolism.
Improvement of fibroid-associated symptoms and quality of life after US-guided high-intensity focused ultrasound (HIFU) of uterine fibroids
Authors: Tonguc Tolga , Recker Florian , Ganslmeier Judith , Strunk Holger M. , Pieper Claus C. , Ramig Olga , Welz Simone , Egger Eva K. , Mutschler Nikola , Warwas Leonie , Essler Markus , Mustea Alexander , Conrad Rupert , Marinova Milka 
Published: December 2022

AbstractUterine fibroids are the most common benign uterine tumors and can cause various severe symptoms as abnormal menstrual bleeding or pelvic pain. Therefore, the primary objective in the treatment of uterine fibroids is a sufficient symptom relief. Ultrasound (US)-guided High-intensity focused ultrasound (HIFU) is an effective non-invasive treatment strategy for ablation of uterine fibroids that can achieve a significant tumor volume reduction. The aim of the study is to evaluate if US-guided HIFU treatment can reduce fibroid-associated symptoms leading to an improvement of health-related quality of life. Fifty-five women with symptomatic uterine fibroids underwent US-guided HIFU ablation. Clinical evaluation was performed on the basis of the Uterine Fibroid Symptom and Health-Related Quality of Life Questionnaire (UFS-QOL) at baseline, 6 weeks, 3, 6, 9 and 12 months after HIFU. Imaging follow-up included contrast-enhanced ultrasound (CEUS) and contrast-enhanced MRI. A significant reduction of the Symptom Severity Scale (SSS) was observed between 6 weeks and 12 months after HIFU (49.9 ± 19.4 at baseline vs. 42.2 ± 20.1 at 6 weeks and 23.6 ± 12.7 at 12 months after treatment, p < 0.001) correlating with a significant improvement (p < 0.001) of Health-related Quality of Life (HRQL) (52.5 ± 22.7 at baseline vs. 59.8 ± 22 at 6 weeks and 77.9 ± 17.3 at 12 months after treatment). Significant postinterventional improvement was observed in every subscale of HRQL. In the majority of patients, only minor, short-lasting and self-limiting side effects were observed, e.g. soft tissue edema of the anterior lower abdominal wall in the acoustic pathway or transient moderate lower abdominal pain as during menstruation. One patient with a very large fibroid experienced strong short-lasting pain after the procedure; two patients experienced post-procedurally a transient sciatic nerve irritation. US-guided HIFU of uterine fibroids reduces disease-related symptoms and improves health-related quality of life.
Experimentally induced myopia and myopic astigmatism alter retinal electrophysiology in chickens
Authors: Vyas Sonal Aswin , Lakshmanan Yamunadevi , Chan Henry Ho-lung , Leung Tsz-wing , Kee Chea-su 
Published: December 2022

AbstractMyopia (or “short-sightedness”) and astigmatism are major causes of visual impairment worldwide. Significant amounts of astigmatism are frequently observed in infants and have been associated with myopia development. Although it is well established that both myopia and astigmatism are associated with ocular structural changes from anterior to posterior segments, very little is known on how these refractive errors alter retinal functions. This study investigated the effects of experimentally induced myopia and myopic-astigmatism on retinal electrophysiology by using an image-guided, multifocal global flash stimulation in chickens, a widely used animal model for refractive error development. Myopia and myopic-astigmatism were experimentally induced, respectively, by wearing spherical (− 10 D, n = 12) and sphero-cylindrical lenses (− 6.00 DS/− 8.00 DCx90: Hyperopic With-The Rule, H-WTR, n = 15; − 6.00 DS/− 8.00 DCx180: Hyperopic Against-The-Rule, H-ATR, n = 11) monocularly for a week (post-hatching day 5 to 12). An aged-matched control group without any lens treatment provided normal data (n = 12). Multifocal electrophysiological results revealed significant regional variation in the amplitude of induced component (IC) (central greater than peripheral; both p < 0.05) in the normal and H-ATR groups, but not in the – 10 D and H-WTR groups. Most importantly, for the first time, our results showed that both H-WTR and H-ATR groups exhibited a significantly longer implicit time of the inner retinal response at the central region when compared to the normal and – 10 D groups, highlighting a significant role of astigmatism in retinal physiology.
Plastid phylogenomics uncovers multiple species in Medicago truncatula (Fabaceae) germplasm accessions
Authors: Choi In-Su , Wojciechowski Martin F. , Steele Kelly P. , Hopkins Andrew , Ruhlman Tracey A. , Jansen Robert K. 
Published: December 2022

AbstractMedicago truncatula is a model legume that has been extensively investigated in diverse subdisciplines of plant science. Medicago littoralis can interbreed with M. truncatula and M. italica; these three closely related species form a clade, i.e. TLI clade. Genetic studies have indicated that M. truncatula accessions are heterogeneous but their taxonomic identities have not been verified. To elucidate the phylogenetic position of diverse M. truncatula accessions within the genus, we assembled 54 plastid genomes (plastomes) using publicly available next-generation sequencing data and conducted phylogenetic analyses using maximum likelihood. Five accessions showed high levels of plastid DNA polymorphism. Three of these highly polymorphic accessions contained sequences from both M. truncatula and M. littoralis. Phylogenetic analyses of sequences placed some accessions closer to distantly related species suggesting misidentification of source material. Most accessions were placed within the TLI clade and maximally supported the interrelationships of three subclades. Two Medicago accessions were placed within a M. italica subclade of the TLI clade. Plastomes with a 45-kb (rpl20-ycf1) inversion were placed within the M. littoralis subclade. Our results suggest that the M. truncatula accession genome pool represents more than one species due to possible mistaken identities and gene flow among closely related species.
Improved multi-objective differential evolution algorithm based on a decomposition strategy for multi-objective optimization problems
Authors: Fan Mingwei , Chen Jianhong , Xie Zuanjia , Ouyang Haibin , Li Steven , Gao Liqun 
Published: December 2022

AbstractMany real-world engineering problems need to balance different objectives and can be formatted as multi-objective optimization problem. An effective multi-objective algorithm can achieve a set of optimal solutions that can make a tradeoff between different objectives, which is valuable to further explore and design. In this paper, an improved multi-objective differential evolution algorithm (MOEA/D/DEM) based on a decomposition strategy is proposed to improve the performance of differential evolution algorithm for practical multi-objective nutrition decision problems. Firstly, considering the neighborhood characteristic, a neighbor intimacy factor is designed in the search process for enhancing the diversity of the population, then a new Gaussian mutation strategy with variable step size is proposed to reduce the probability of escaping local optimum area and improve the local search ability. Finally, the proposed algorithm is tested by classic test problems (DTLZ1-7 and WFG1-9) and applied to the multi-objective nutrition decision problems, compared to the other reported multi-objective algorithms, the proposed algorithm has a better search capability and obtained competitive results.
Effects of ultrasonic-assisted nickel pretreatment method on electroless copper plating over graphene
Authors: Peng Qingyan , Tan Xiaodong , Venkataraman Mohanapriya , Militky Jiri , Xiong Wei , Mahendran Arunjunai Raj , Lammer Herfried , Kejzlar Pavel 
Published: December 2022

AbstractIn this paper, copper deposited graphene was fabricated through electroless plating. A novel and facile pretreatment method is introduced based on ultrasonic treatment with nickel nano-particles as the catalytic core. This method abandons the sensitization and activation process in the traditional pretreatment that reduces the time and economic cost dramatically. The static contact angle was determined by an Olympus BX51M optical microscope. The surface morphology and plating composition were characterized via scanning electron microscope (SEM) and energy dispersive spectroscopy (EDS), the infrared radiation (IR) transmittance spectra of the copper plated graphene were measured by Fourier transform infrared spectroscopy (FTIR), the layer structure was measured by Raman spectrum, the phase identification was identified by X-ray diffraction (XRD), the thermogravimetric analysis (TGA) (Q5000 TA instruments, USA) was carried out to detect the thermal characteristics. The electrical resistivity of copper-plated graphene was performed in an especially designed apparatus. The results show that the surface of graphene is coarsened, and the size is reduced after ultrasonic treatment, which can facilitate the nucleation and fine particle distribution of metal. The electroless plated efficiency of copper of the nickel pretreatment copper-plated graphene is 64.27 wt%, higher than that of generic copper-plated graphene at 58.62 wt%. The resistivity decreases rapidly from 1.69 × 10–2 Ω cm of the original Gr to 0.79 × 10–2 Ω cm of Cu/Ni@Gr due to the large number of fine copper particles scattered around the graphene.
Aphid species specializing on milkweed harbor taxonomically similar bacterial communities that differ in richness and relative abundance of core symbionts
Authors: Enders Laramy , Hansen Thorsten , Brichler Kirsten , Couture John , French Elizabeth 
Published: December 2022

AbstractHost plant range is arguably one of the most important factors shaping microbial communities associated with insect herbivores. However, it is unclear whether host plant specialization limits microbial community diversity or to what extent herbivores sharing a common host plant evolve similar microbiomes. To investigate whether variation in host plant range influences the assembly of core herbivore symbiont populations we compared bacterial diversity across three milkweed aphid species (Aphisnerii, Aphis asclepiadis, Myzocallis asclepiadis) feeding on a common host plant (Asclepias syriaca) using 16S rRNA metabarcoding. Overall, although there was significant overlap in taxa detected across all three aphid species (i.e. similar composition), some structural differences were identified within communities. Each aphid species harbored bacterial communities that varied in terms of richness and relative abundance of key symbionts. However, bacterial community diversity did not vary with degree of aphid host plant specialization. Interestingly, the narrow specialist A.asclepiadis harbored significantly higher relative abundances of the facultative symbiont Arsenophonus compared to the other two aphid species. Although many low abundance microbes were shared across all milkweed aphids, key differences in symbiotic partnerships were observed that could influence host physiology or additional ecological variation in traits that are microbially-mediated. Overall, this study suggests overlap in host plant range can select for taxonomically similar microbiomes across herbivore species, but variation in core aphid symbionts within these communities may still occur.
Tyrosine-protein kinase Yes controls endothelial junctional plasticity and barrier integrity by regulating VE-cadherin phosphorylation and endocytosis
Authors: Jin Yi , Ding Yindi , Richards Mark , Kaakinen Mika , Giese Wolfgang , Baumann Elisabeth , Szymborska Anna , Rosa André , Nordling Sofia , Schimmel Lilian , Akmeriç Emir Bora , Pena Andreia , Nwadozi Emmanuel , Jamalpour Maria , Holstein Katrin , Sáinz-Jaspeado Miguel , Bernabeu Miguel O. , Welsh Michael , Gordon Emma , Franco Claudio A. , Vestweber Dietmar , Eklund Lauri , Gerhardt Holger , Claesson-Welsh Lena 
Published: December 2022

AbstractVascular endothelial (VE)-cadherin in endothelial adherens junctions is an essential component of the vascular barrier, critical for tissue homeostasis and implicated in diseases such as cancer and retinopathies. Inhibitors of Src cytoplasmic tyrosine kinase have been applied to suppress VE-cadherin tyrosine phosphorylation and prevent excessive leakage, edema and high interstitial pressure. Here we show that the Src-related Yes tyrosine kinase, rather than Src, is localized at endothelial cell (EC) junctions where it becomes activated in a flow-dependent manner. EC-specific Yes1 deletion suppresses VE-cadherin phosphorylation and arrests VE-cadherin at EC junctions. This is accompanied by loss of EC collective migration and exaggerated agonist-induced macromolecular leakage. Overexpression of Yes1 causes ectopic VE-cadherin phosphorylation, while vascular leakage is unaffected. In contrast, in EC-specific Src deficiency, VE-cadherin internalization is maintained and leakage is suppressed. In conclusion, Yes-mediated phosphorylation regulates constitutive VE-cadherin turnover, thereby maintaining endothelial junction plasticity and vascular integrity.
Speech Intervention for Children With Cleft Palate Using Principles of Motor Learning
Authors: Hanley Leah , Ballard Kirrie J. , Dickson Alicia , Purcell Alison 
Published: December 2022

Purpose:
This is a pilot study to apply an articulatory kinematic speech intervention that uses the principles of motor learning (PML) to improve speech and resonance outcomes for children with cleft palate. It is hypothesized that (a) treatment that applies select PML during practice will improve production of treated phonemes, representing both active and inconsistent passive errors, at word level in children with cleft palate; (b) effects of practice on phonemes with active or inconsistent passive errors will generalize to untreated exemplars of treated phonemes; and (c) learning will be retained for at least 1-month posttreatment.

Method:
A multiple-baseline design across participants combined with a crossover single-case experimental model was used. Participants attended two 8-week blocks of twice-weekly face-to-face speech therapy (40–50 min/treatment) to treat active and inconsistent passive cleft speech errors using articulatory kinematic speech intervention that applied PML. The participants were four children with cleft-type speech errors. The primary dependent variable measured was percentage of words correct across treatment items, generalization items, and control items. Perceptual accuracy of target words was scored. Effect sizes were calculated to quantify the magnitude of treatment effect.

Results:
For three children with active and inconsistent passive cleft speech errors and one child with active cleft speech errors and developmental phonological speech errors, this approach resulted in improvements to their treated items and generalization to their untreated items. Inconsistent passive cleft speech errors were particularly responsive to the treatment in the three children who presented with these errors.

Conclusion:
This Phase I study has shown that articulatory kinematic speech intervention that applies the PML is effective in improving the speech outcomes for children with cleft palate and that there is validity in pursuing further research into this approach.

Supplemental Material:

https://doi.org/10.23641/asha.21644831
Noise-Vocoded Sentence Recognition and the Use of Context in Older and Younger Adult Listeners
Authors: Moberly Aaron C. , Varadarajan Varun V. , Tamati Terrin N. 
Published: December 2022

Purpose:
When listening to speech under adverse conditions, older adults, even with “age-normal” hearing, face challenges that may lead to poorer speech recognition than their younger peers. Older listeners generally demonstrate poorer suprathreshold auditory processing along with aging-related declines in neurocognitive functioning that may impair their ability to compensate using “top-down” cognitive–linguistic functions. This study explored top-down processing in older and younger adult listeners, specifically the use of semantic context during noise-vocoded sentence recognition.

Method:
Eighty-four adults with age-normal hearing (45 young normal-hearing [YNH] and 39 older normal-hearing [ONH] adults) participated. Participants were tested for recognition accuracy for two sets of noise-vocoded sentence materials: one that was semantically meaningful and the other that was syntactically appropriate but semantically anomalous. Participants were also tested for hearing ability and for neurocognitive functioning to assess working memory capacity, speed of lexical access, inhibitory control, and nonverbal fluid reasoning, as well as vocabulary knowledge.

Results:
The ONH and YNH listeners made use of semantic context to a similar extent. Nonverbal reasoning predicted recognition of both meaningful and anomalous sentences, whereas pure-tone average contributed additionally to anomalous sentence recognition. None of the hearing, neurocognitive, or language measures significantly predicted the amount of context gain, computed as the difference score between meaningful and anomalous sentence recognition. However, exploratory cluster analyses demonstrated four listener profiles and suggested that individuals may vary in the strategies used to recognize speech under adverse listening conditions.

Conclusions:
Older and younger listeners made use of sentence context to similar degrees. Nonverbal reasoning was found to be a contributor to noise-vocoded sentence recognition. However, different listeners may approach the problem of recognizing meaningful speech under adverse conditions using different strategies based on their hearing, neurocognitive, and language profiles. These findings provide support for the complexity of bottom-up and top-down interactions during speech recognition under adverse listening conditions.
X-ray analysis of JWST’s first galaxy cluster lens SMACS J0723.3−7327
Authors: Liu A. , Bulbul E. , Ramos-Ceja M. E. , Sanders J. S. , Ghirardini V. , Bahar Y. E. , Yeung M. , Gatuzz E. , Freyberg M. , Garrel C. , Zhang X. , Merloni A. , Nandra K. 
Published: December 2022

Context. SMACS J0723.3−7327 is the first galaxy cluster lens observed by James Webb Space Telescope (JWST). Based on its early release observation data, several groups have reported the results on strong lensing analysis and mass distribution of this cluster. The new lens model dramatically improves upon previous results, thanks to JWST’s unprecedented sensitivity and angular resolution. However, limited by the angular coverage of the JWST data, the strong lensing models only cover the central region. Conducting an X-ray analysis on the hot intracluster medium (ICM) is necessary to obtain a more complete constraint on the mass distribution in this very massive cluster.
Aims. In this work, we perform a comprehensive X-ray analysis of J0723 with an aim to obtain accurate ICM hydrostatic mass measurements, using the X-ray data from Spectrum Roentgen Gamma (SRG)/eROSITA and Chandra X-ray observatories. By comparing the hydrostatic mass profile with the strong lensing model, we aim to provide the most reliable constraint on the distribution of mass up to R500.
Methods. Thanks to the eROSITA all-sky survey and Chandra, which provide high signal-to-noise ratio (S/N) and high angular resolution data, respectively, we were able to constrain the ICM gas density profile and temperature profile with good accuracy both in the core and to the outskirts. With the density and temperature profiles, we computed the hydrostatic mass profile, which was then projected along the line of sight to compare with the mass distribution obtained from the recent strong lensing analysis based on JWST data. We also deprojected the strong lensing mass distribution using the hydrostatic mass profile obtained in this work.
Results. The X-ray results obtained from eROSITA and Chandra are in very good agreement. The hydrostatic mass profiles we measured in this work, both projected and deprojected, are in good agreement with recent strong lensing results based on JWST data, at all radii. The projected hydrostatic mass within 128 kpc (the estimated Einstein radius) is (8.0 ± 0.7)×1013 M⊙, consistent with the strong lensing mass reported in recent literature. With the hydrostatic mass profile, we measured R2500 = 0.54 ± 0.04 Mpc and M2500 = (3.5 ± 0.8)×1014 M⊙, while the R500 and M500 are 1.32 ± 0.23 Mpc and (9.8 ± 5.1)×1014 M⊙, with a relatively larger error bar due to the rapidly decreasing S/N in the outskirts. We also find that the radial acceleration relation in J0723 is inconsistent with the RAR for spiral galaxies, implying that the latter is not a universal property of gravity across all mass scales.