bluuebunny/crossref_metadata_2025_split huggingface dataset:
Croatian high-resolution monthly gridded dataset of homogenised surface air temperature
Authors: Perčec Tadić Melita , Pasarić Zoran , Guijarro José A. 
Published: November 2022

AbstractHomogenised climatological series and gridded data are the basis for climate monitoring and climate change detection. Considering this, monthly mean temperatures from 122 Croatian stations were homogenised, and high-resolution monthly gridded data were developed for the 1981–2018 period. Homogenisation needs to be performed on stations from the same climate region; therefore, hierarchical clustering is introduced to define those climate regions in Croatia. The breaks of homogeneity were detected by the standard normal homogeneity test on 54 stations. Regression kriging was applied to produce monthly grids for each month in the analysed period. The quality of the interpolation assessed by leave-one-out cross-validation resulted in a root mean square error of 0.7 °C. The quality of spatial interpolation is supplemented with normalised error maps. The derived homogenised station data and monthly grids are necessary for national climate monitoring, the production of climate normals and the estimation of trends. After 1999, average annual anomalies from the 30-year climate standard normal 1981–2010 were positive and up to 1.4 °C warmer than the average and only occasionally negative. The measured amount, sign and significance of the trend were accurately captured on the trend maps calculated from the monthly maps. Significant strong warming was observed and mapped over the entire Croatian territory in April, June, July, August and November. It was stronger inland than on the coast. Annual trends were significant and ranged from 0.3 °C/decade to 0.7 °C/decade. There was no observational evidence of enhanced elevation-dependent warming over elevations from 750 to 1594 m.
Explainable software systems: from requirements analysis to system evaluation
Authors: Chazette Larissa , Brunotte Wasja , Speith Timo 
Published: November 2022

AbstractThe growing complexity of software systems and the influence of software-supported decisions in our society sparked the need for software that is transparent, accountable, and trustworthy. Explainability has been identified as a means to achieve these qualities. It is recognized as an emerging non-functional requirement (NFR) that has a significant impact on system quality. Accordingly, software engineers need means to assist them in incorporating this NFR into systems. This requires an early analysis of the benefits and possible design issues that arise from interrelationships between different quality aspects. However, explainability is currently under-researched in the domain of requirements engineering, and there is a lack of artifacts that support the requirements engineering process and system design. In this work, we remedy this deficit by proposing four artifacts: a definition of explainability, a conceptual model, a knowledge catalogue, and a reference model for explainable systems. These artifacts should support software and requirements engineers in understanding the definition of explainability and how it interacts with other quality aspects. Besides that, they may be considered a starting point to provide practical value in the refinement of explainability from high-level requirements to concrete design choices, as well as on the identification of methods and metrics for the evaluation of the implemented requirements.
Cognitive load in immersive media settings: the role of spatial presence and cybersickness
Authors: Breves Priska , Stein Jan-Philipp 
Published: November 2022

AbstractFaced with the ongoing diversification and commercial success of highly immersive media technologies (e.g., VR headsets), both content producers and scientific scholars have become highly invested in understanding the psychological consequences of experiencing media in these new and lifelike ways. While many studies underscore positive effects of high media immersivity—such as increased enjoyment or persuasive success—others warn about the intense cognitive load that technologies such as VR might put on their users. In a laboratory experiment withN = 121 participants, we compare the cognitive load experienced while watching a 360° video on a laptop screen or via an immersive VR head-mounted display. Furthermore, we scrutinize two prominent explanations for the additional cognitive load in immersive media settings, i.e., the role of spatial presence and cybersickness. As expected, the VR condition results in higher cognitive load, spatial presence, and cybersickness than the 2D condition. However, by means of a parallel mediation model, we observe that only cybersickness emerges as a meaningful mediator of participants’ strained cognitive capacity; spatial presence, on the other hand, remains statistically irrelevant in this regard. We discuss our findings considering implications for media producers and future research.
Transcriptional expression of CXCL10 and STAT1 in lupus nephritis and the intervention effect of triptolide
Authors: Shi Dongliang , Li Yan , Shi Xiaomei , Yao Meihong , Wu Dan , Zheng Yuhui , Lin Qing , Yang Yinghong 
Published: November 2022

Abstract

Objective
This study screened out the key genes associated with the occurrence and development of lupus nephritis (LN) using bioinformatics methods, and then explored the expression of key genes in LN and the inhibitory effect of triptolide.

Methods
The GEO2R online tool in the GEO database was used to perform differential analysis of gene expression in LN tissues and normal kidney tissues. The GO function and KEGG pathway enrichment analysis of differentially expressed genes (DEGs), STRING, and Cytoscape software were used to build a protein–protein interaction network (PPI) to screen out the Hub gene. Mouse glomerular mesangial cells (MMC) were randomly divided into a control group, an interferon-γ (IFN-γ) stimulation group, and a triptolide intervention group. The relative expression of CXCL10 mRNA in each group was detected by real-time fluorescent quantitative PCR (RT-PCR). CXCL10 secretion was detected by enzyme-linked immunosorbent assay (ELISA), and Western blot was used to detect the expression of the JAK/STAT1 signaling pathway–related proteins STAT1 and p-STAT1 in each group.

Results
Bioinformatics showed that there were 22 DEGs expression differences in the GEO database. The GO enrichment analysis showed that biological process (BP) such as the type I interferon signaling pathway, innate immune response, IFN-γ-mediated signaling pathway, virus defense response, and immune response were significantly regulated by DEGs. Through the combination of String database analysis and cytoscape software, it was found that STAT1 and CXCL10 are closely related to LN. Experimental results showed that IFN-γ induces the expression of CXCL10 mRNA and protein by activating the JAK/STAT1 signaling pathway, while triptolide inhibits the expression of CXCL10 mRNA and protein by inhibiting the JAK/STAT1 signaling pathway.

Conclusion
STAT1 and CXCL10 are the key genes in the occurrence and development of LN. IFN-γ induces the expression of CXCL10 by activating the JAK/STAT1 signaling pathway, while triptolide inhibits the expression of CXCL10 by blocking the JAK/STAT1 signaling pathway. Inhibition of the JAK/STAT1 signaling pathway and CXCL10 expression is expected to become a potential target for the treatment of LN.

Key Points• Bioinformatics showed that there were 22 DEGs expression differences in the GEO database.• Through the combination of String database analysis and Cytoscape software, it was found that STAT1 and CXCL10 are closely related to LN.• Experimental results showed that IFN-γ induces the expression of CXCL10 mRNA and protein by activating the JAK/STAT1 signaling pathway, while triptolide inhibits the expression of CXCL10 mRNA and protein by inhibiting the JAK/STAT1 signaling pathway.
Differentiation and Maturation of Muscle and Fat Cells in Cultivated Seafood: Lessons from Developmental Biology
Authors: Bomkamp Claire , Musgrove Lisa , Marques Diana M. C. , Fernando Gonçalo F. , Ferreira Frederico C. , Specht Elizabeth A. 
Published: November 2022

Abstract
Cultivated meat, also known as cultured or cell-based meat, is meat produced directly from cultured animal cells rather than from a whole animal. Cultivated meat and seafood have been proposed as a means of mitigating the substantial harms associated with current production methods, including damage to the environment, antibiotic resistance, food security challenges, poor animal welfare, and—in the case of seafood—overfishing and ecological damage associated with fishing and aquaculture. Because biomedical tissue engineering research, from which cultivated meat draws a great deal of inspiration, has thus far been conducted almost exclusively in mammals, cultivated seafood suffers from a lack of established protocols for producing complex tissues in vitro. At the same time, fish such as the zebrafish Danio rerio have been widely used as model organisms in developmental biology. Therefore, many of the mechanisms and signaling pathways involved in the formation of muscle, fat, and other relevant tissue are relatively well understood for this species. The same processes are understood to a lesser degree in aquatic invertebrates. This review discusses the differentiation and maturation of meat-relevant cell types in aquatic species and makes recommendations for future research aimed at recapitulating these processes to produce cultivated fish and shellfish.
Workplace Mental Health Disclosure, Sustainable Employability and Well-Being at Work: A Cross-Sectional Study Among Military Personnel with Mental Illness
Authors: Bogaers Rebecca , Geuze Elbert , van Weeghel Jaap , Leijten Fenna , van de Mheen Dike , Rüsch Nicolas , Rozema Andrea , Brouwers Evelien 
Published: November 2022

AbstractPurpose Disclosure of mental illness to a supervisor can have positive (e.g. supervisor support) and negative consequences (e.g. stigma). However, research on the association between disclosure and sustainable employability and well-being at work is scarce. The aim of this study was to investigate the association between the disclosure decision (yes/no), experiences with the decision (positive/negative) and sustainable employment and well-being at work among military personnel with mental illness (N = 323). Methods A cross-sectional questionnaire study was conducted. Descriptive and regression (linear and ordinal) analyses were performed. Comparisons were made between those with positive and negative disclosure experiences. Results Disclosure decision (yes/no) was not significantly associated with any of the measures of sustainable employability and well-being at work. However, positive disclosure experiences were significantly associated with higher scores on almost all measures of sustainable employability and well-being at work. Those with negative disclosure experiences reported significantly more shame (Mpos = 2.42, Mneg = 2.78, p < .05) and discrimination (Mpos = 1.70, Mneg = 2.84, p < .001). Those with a positive disclosure experience, reported significantly more supervisor support (Mpos = 3.20, Mneg = 1.94, p < .001). Conclusion We did not find evidence that the disclosure decision itself is related to measures of sustainable employment and well-being at work. In contrast, how participants had experienced their (non-)disclosure decision was significantly related to almost all measures. This emphasizes the importance of the work environments reactions to disclosure and mental illness in the workplace. Future research and interventions should focus on increasing the likelihood of positive disclosure experiences through creating a more inclusive work environment, with more supervisor support and less stigma.
Evolution of Coronary Calcium Screening for Assessment of Atherosclerotic Cardiovascular Disease Risk and Role in Preventive Cardiology
Authors: Wong Nathan D. 
Published: November 2022

Abstract
Purpose of Review
Coronary artery calcium (CAC) is an important measure of subclinical atherosclerosis and strongly predicts atherosclerotic cardiovascular disease (ASCVD) outcomes. The purpose of this review is to discuss the key studies that have helped to establish its role as an important screening tool and its place in preventive cardiology.

Recent Findings
Epidemiologic studies document a strong relation of age, race/ethnicity, and risk factors with the prevalence and extent of CAC. Large-scale registry and prospective investigations show CAC to be the strongest subclinical disease predictor of ASCVD outcomes, with higher CAC scores associated with successively higher risks and those with a CAC score of 0 having a long-term “warranty” against having events. Moreover, CAC is associated with greater initiation of preventive health behaviors and therapy. Current US guidelines utilize CAC to inform the treatment decision for statin therapy. Further study is underway to document whether CAC screening will ultimately improve clinical outcomes.

Summary
CAC is well established as the most important subclinical cardiovascular disease measure for prediction of future ASCVD outcomes and can be used for informing the treatment decision for preventive therapies.
Value Change, Value Conflict, and Policy Innovation: Understanding the Opposition to the Market-Based Economic Dispatch of Electricity Scheme in India Using the Multiple Streams Framework
Authors: Goyal Nihit , Iychettira Kaveri 
Published: November 2022

AbstractAs policy innovation is essential for upscaling responsible innovation, understanding its relationship to value change(s) occurring or sought in sociotechnical systems is imperative. In this study, we ask: what are the different types of values in the policy process? And, how does value change influence policy innovation? We propose a disaggregation of values and value change based on a four-stream variant of the multiple streams framework (MSF), a conceptual lens increasingly used for explaining policy innovation in sociotechnical transitions. Specifically, we posit that the values that ‘govern’ problem framing, policy design, political decision making, and technological diffusion can evolve relatively independently, potentially leading to value conflict. We apply this framework to the ongoing case of the market-based economic dispatch of electricity (MBED) policy in the Indian energy transition using content analysis. We find that the MBED scheme—with its emphasis on efficiency (problem), economic principles (policy), low-cost dispatch (technology), and centralization (politics)—attempts value change in each stream. Each instance of value change is, however, widely contested, with the ensuing value conflicts resulting in significant opposition to this policy innovation. We conclude that a disaggregation of values based on the MSF can facilitate an analysis of value change and value conflict in sociotechnical transitions and lay the foundation for systematically studying the relationships among technological change, value change, and policy change.
The Ethics of Supernumerary Robotic Limbs. An Enactivist Approach
Authors: Di Stefano Nicola , Jarrassé Nathanaël , Valera Luca 
Published: November 2022

AbstractSupernumerary robotic limbs are innovative devices in the field of wearable robotics which can provide humans with unprecedented sensorimotor abilities. However, scholars have raised awareness of the ethical issues that would arise from the large adoption of technologies for human augmentation in society. Most negative attitudes towards such technologies seem to rely on an allegedly clear distinction between therapy and enhancement in the use of technological devices. Based on such distinction, people tend to accept technologies when used for therapeutic purposes (e.g., prostheses), but tend to raise issues when similar devices are used for upgrading a physical or cognitive ability (e.g., supernumerary robotics limbs). However, as many scholars have pointed out, the distinction between therapy and enhancement might be theoretically flawed. In this paper, we present an alternative approach to the ethics of supernumerary limbs which is based on two related claims. First, we propose to conceive supernumerary limbs as tools that necessarily modify our psychological and bodily identity. At the same time, we stress that such a modification is not ethically bad in itself; on the contrary, it drives human interaction with the environment. Second, by comparing our view with the extended mind thesis, we claim that the mediation through tools is crucial for the formation of novel meanings and skills that constitute human interaction with the world. We will relate the latter claim to enactivism as a helpful theoretical perspective to frame issues related to artificial limbs and, more in general, to technologies for augmentation. Based on this approach, we finally sketch some suggestions for future directions in the ethics of supernumerary limbs.
Repentance as Rebuke: Betrayal and Moral Injury in Safety Engineering
Authors: Dekker Sidney W. A. , Layson Mark D. , Woods David D. 
Published: November 2022

AbstractFollowing other contributions about the MAX accidents to this journal, this paper explores the role of betrayal and moral injury in safety engineering related to the U.S. federal regulator’s role in approving the Boeing 737MAX—a plane involved in two crashes that together killed 346 people. It discusses the tension between humility and hubris when engineers are faced with complex systems that create ambiguity, uncertain judgements, and equivocal test results from unstructured situations. It considers the relationship between moral injury, principled outrage and rebuke when the technology ends up involved in disasters. It examines the corporate backdrop against which calls for enhanced employee voice are typically made, and argues that when engineers need to rely on various protections and moral inducements to ‘speak up,’ then the ethical essence of engineering—skepticism, testing, checking, and questioning—has already failed.
Broadband optical frequency comb generation based on single electro-absorption modulation driven by radio frequency coupled signals
Authors: Jiang Pan , Li Peili , Fan Yiming 
Published: November 2022

AbstractBroadband optical frequency comb (OFC) generation based on a single electro-absorption modulator (EAM) is proposed. The EAM is driven by a radio frequency (RF) multi-frequency signal generated by a multiplication coupler composed of an electrical power splitter and an arithmetic circuit. Thus the number of comb-lines of the generated OFC can be increased. A complete theoretical model of OFC generation by an EAM driven by nth power of the RF source is established, and the performance of the OFC is analyzed by using OptiSystem software. The results show that, the number of comb-lines of the OFC is positively correlated with the number of multiplication of the RF source signal. The frequency spacing of the comb-lines is twice the frequency of the RF source signal and is tunable by adjusting the frequency of the RF source signal. Increasing chirp factor and modulation index of EAM could increase the number of comb-lines of the generated OFC. The amplitude of the RF source signal had little impact on the flatness of the OFC and the average OFC power. The scheme developed is not only simple and low-cost, but also can produce a large number of comb-lines.
Graphical Abstract
Pointwise Expansion of Degenerating Immersions of Finite Total Curvature
Authors: Michelat Alexis , Rivière Tristan 
Published: November 2022

AbstractGeneralising classical result of Müller and Šverák (J. Differ. Geom. 42(2), 229-258, 1995), we obtain a pointwise estimate of the conformal factor of sequences of conformal immersions from the unit disk of the complex plane of uniformly bounded total curvature and converging strongly outside of a concentration point towards a branched immersions for which the quantization of energy holds. We show that the multiplicity associated to the conformal parameter becomes eventually constant to an integer equal to the order of the branch point of the limiting branched immersion. Furthermore, we deduce a$$C^0$$C0convergence of the normal unit in the neck regions. Finally, we show that these improved energy quantizations hold for Willmore surfaces of uniformly bounded energy and precompact conformal class, and for Willmore spheres arising as solutions of min-max problems in the viscosity method.
Astrocytes in Chronic Pain: Cellular and Molecular Mechanisms
Authors: Lu Huan-Jun , Gao Yong-Jing 
Published: November 2022

AbstractChronic pain is challenging to treat due to the limited therapeutic options and adverse side-effects of therapies. Astrocytes are the most abundant glial cells in the central nervous system and play important roles in different pathological conditions, including chronic pain. Astrocytes regulate nociceptive synaptic transmission and network function via neuron–glia and glia–glia interactions to exaggerate pain signals under chronic pain conditions. It is also becoming clear that astrocytes play active roles in brain regions important for the emotional and memory-related aspects of chronic pain. Therefore, this review presents our current understanding of the roles of astrocytes in chronic pain, how they regulate nociceptive responses, and their cellular and molecular mechanisms of action.
Historical biogeography highlights the role of Miocene landscape changes on the diversification of a clade of Amazonian tree frogs
Authors: Ortiz Diego A. , Hoskin Conrad J. , Werneck Fernanda P. , Réjaud Alexandre , Manzi Sophie , Ron Santiago R. , Fouquet Antoine 
Published: November 2022

AbstractThe diversification processes underlying why Amazonia hosts the most species-rich vertebrate fauna on earth remain poorly understood. We studied the spatio-temporal diversification of a tree frog clade distributed throughout Amazonia (Anura: Hylidae:Osteocephalus,Tepuihyla, andDryaderces) and tested the hypothesis that Miocene mega wetlands located in western and central Amazonia impacted connectivity among major biogeographic areas during extensive periods. We assessed the group’s diversity through DNA-based (16S rRNA) species delimitation to identify Operational Taxonomic Units (OTUs) from 557 individuals. We then selected one terminal for each OTU (n = 50) and assembled a mitogenomic matrix (~14,100 bp; complete for 17 terminals) to reconstruct a Bayesian, time-calibrated phylogeny encompassing nearly all described species. Ancestral area reconstruction indicates that each genus was restricted to one of the major Amazonian biogeographic areas (western Amazonia, Guiana Shield and Brazilian Shield, respectively) between ~10 and 20 Mya, suggesting that they diverged and diversified in isolation during this period around the Pebas mega wetland. After 10 Mya and the transition to the modern configuration of the Amazon River watershed, most speciation within each genus continued to occur within each area. InOsteocephalus, only three species expanded widely across Amazonia (< 6 Mya), and all were pond-breeders. Species with other breeding modes remained mostly restricted to narrow ranges. The spectacular radiation ofOsteocephaluswas probably driven by climatic stability, habitat diversity and the acquisition of new reproductive modes along the Andean foothills and western Amazonia. Our findings add evidence to the importance of major hydrological changes during the Miocene on biotic diversification in Amazonia.
Gewissheitsschwund: Über transformatives Führen in der ampeligen Lern-Koalition
Authors: Korte Karl-Rudolf 
Published: November 2022

ZusammenfassungFühren und Entscheiden in Zeiten der Krisenpermanenz und dem damit einhergehenden Gewissheitsschwund wäre schon für erprobte Koalitionsformate eine große Herausforderung. Für die Ampel-Koalition sind diese ungleich größer. Die im vorliegenden Beitrag skizzierten vier Spielarten des transformativen Regierens deuten an, wie das Politikmanagement in der Transformation gelingen kann.