bluuebunny/crossref_metadata_2025_split huggingface dataset:
Recent Progress on Transition-Metal-Mediated Reductive C(sp3)–O Bond Radical Addition and Coupling Reactions
Authors: Chen Yunrong , Gong Hegui , Cheng Li , Lin Quan 
Published: May 2022

AbstractIn this short review, we summarize the recent developments on thermo-driven C(sp3)–O bond radical scission methods and their applications in the construction of C(sp3)–C bonds via conjugate addition with activated double bonds and reductive coupling mediated by economic 3d metals, in particular nickel. We have arranged the review based on three approaches for C(sp3)–O bond radical scission (vide infra). After generating the radical intermediates, their subsequent transformation into C(sp3)–C bonds enabled by C(sp3)–O cross-electrophile coupling with carbon electrophiles is discussed in detail.1	Introduction2	Direct Single-Electron Transfer to a C(sp3)–O Bond3	Radical Scission of Activated C(sp3)–O Bonds via Single-Electron Transfer to Protecting Groups4	In Situ Activation of Alcohols5	Summary and Outlook
The measurement of carbon density profile using charge exchange spectroscopy in KSTAR
Authors: Lee J. K. , Lee H. H. , Ko W. H. , Na B. , Ko J. , Lee M. W. , Lee S. G. 
Published: May 2022

The first measurement of the impurity density profile via charge exchange spectroscopy (CES) has been successfully achieved in KSTAR. Since the neutral beam density profile is essential for the measurement, the neutral beam penetration code that was originally developed for the Alcator C-mod tokamak has been optimized for the KSTAR experimental environment. The method of the impurity density measurement by the KSTAR CES system is introduced and the sensitivity analysis of various physical parameters, such as the effective charge in the estimation of the impurity density, is performed to examine the validation of the method. This method has been applied to measure the C6+ density profile affected by the resonant magnetic perturbations (RMPs), which is mainly used to suppress the edge localized modes (ELMs) in KSTAR. The dynamics of the C6+ density profile represent that the C6+ density decreases immediately after the application of RMPs but recovers soon during the ELM-suppressed phase.
Design considerations for diode-based nonlinear transmission lines
Authors: Gardner Nicholas , Durbhakula Kalyan , Caruso Anthony 
Published: May 2022

Diode-based nonlinear transmission lines (D-NLTL) are a class of pulse shaping networks capable of increasing the discrete spectral content of a pulse at high volumetric power density. However, a systematic design procedure for D-NLTLs is lacking, limiting their prototyping, evaluation, production, and adoption. To produce a D-NLTL design approach, parameters for UHF band (0.3–1 GHz) frequency generation are presented as a function of the input excitation pulse, network topology, and sub-components’ reactive value. Excitation pulse amplitude is found to have a strong effect on center frequency (fc), max frequency (fBragg), peak power (Ppeak), and RF power conversion efficiency (ηRF). In general, when cell inductance is decreased, both fc and signal propagation velocity are increased. The results are then presented as an example to design, build, test, and compare a 40-cell D-NLTL whose measured fc and fBragg are 256 and 446 MHz, respectively. Finally, we used the parameter space study results and empirical validation to present controllable waveform design rules-of-thumb.
The persuasive potential of metaphor when framing Mexican migrants and migration
Authors: De Backer Laurence , Enghels Renata 
Published: May 2022

AbstractResearch into the persuasive quality of metaphor has a long standing tradition, with the topic of migration embodying one of its pet discourse genres. Yet, only few studies have recognized the existence of identical metaphors occurring across the ideological divide. The present paper explores the way in which three US-based news outlets with broadly different group alignments and overall attitudes in relation to the issue of migration wield metaphor to frame the Mexican migration debate in the US. The data suggests that, contrary to what one might expect, the mayor point of variation between these news instances does not consist in a predilection for idiosyncratic source domains. Rather, the three news sources appear to diverge most significantly in their situational use of similar metaphors. On a methodological plane, this case study illustrates the necessity of inspecting metaphor frames more closely, attending to their semantic roles and broader context, if we want to make assertions about the ideological implications and potential social impact of metaphor on public opinion formation. On a social and theoretical level, it sheds light on the ways in which these three news outlets employ metaphors to construct the social identity of ‘Mexican migrants’ living in the US in line with their stance on the matter, and to a possibly persuasive effect.
Rabbit reproduction.
Authors: Lukefahr Steven D. , McNitt James I. , Cheeke Peter R. , Patton Nephi M. 
Published: May 2022

Abstract

The purpose of this chapter is to provide an overview of the processes and the major hormones involved in reproduction. Special emphasis has been placed on those aspects that are of direct concern to the rabbit producer. Readers wishing more detailed information regarding this topic are directed to books that deal specifically with reproductive physiology.
Arterial pressure pulse wave separation analysis using a multi-Gaussian decomposition model
Authors: Manoj Rahul , Raj Kiran V , Nabeel P M , Sivaprakasam Mohanasankar , Joseph Jayaraj 
Published: May 2022

Abstract

Objective. Methods for separating the forward–backward components from blood pulse waves rely on simultaneously measured pressure and flow velocity from a target artery site. Modelling approaches for flow velocity simplify the wave separation analysis (WSA), providing a methodological and instrumentational advantage over the former; however, current methods are limited to the aortic site. In this work, a multi-Gaussian decomposition (MGD) modelled WSA (MGDWSA) is developed for a non-aortic site such as the carotid artery. While the model is an adaptation of the existing wave separation theory, it does not rely on the information of measured or modelled flow velocity. Approach. The proposed model decomposes the arterial pressure waveform using weighted and shifted multi-Gaussians, which are then uniquely combined to yield the forward (P
F(t)) and backward (P
B(t)) pressure wave. A study using the database of healthy (virtual) subjects was used to evaluate the performance of MGDWSA at the carotid artery and was compared against reference flow-based WSA methods. Main results. The MGD modelled pressure waveform yielded a root-mean-square error (RMSE) < 0.35 mmHg. Reliable forward–backward components with a group average RMSE <2.5 mmHg for P
F(t) and P
B(t) were obtained. When compared with the reference counterparts, the pulse pressures (ΔP
F and ΔP
B), as well as reflection quantification indices, showed a statistically significant strong correlation (r > 0.96, p < 0.0001) and (r > 0.83, p < 0.0001) respectively, with an insignificant (p > 0.05) bias. Significance. This study reports WSA for carotid pressure waveforms without assumptions on flow conditions. The proposed method has the potential to adapt and widen the vascular health assessment techniques incorporating pulse wave dynamics.
Novel module architecture for wideband multichannel multi band down conversion with built in Local oscillators
Authors: Pattar Madiwalesh , Anand Gaurav 
Published: May 2022

Abstract
Wide band down converters employed in the field of electronic warfare (EW) process multiple channels simultaneously and in each channel RF signal is split and processed in multi bands. In each channel, RF signal ranging from L to C Band is split into three bands as L, S & C Bands. L Band is directly processed S & C Bands are down converted to identical Intermediate frequency (IF) in UHF to L Band using two different local oscillators (LOs) generated internally. Local Oscillator with low Phase Noise did not introduce jitter on RF input. Module architecture described here is for four channels, extendable to multiple channels.
Design of enhanced gain patch antenna at 2.4 GHz and 3.5 GHz for wireless application
Authors: Azeman Mohammad Addad , Malek Norun Abdul , Mohammad Sarah Yasmin , Ghazali Mohd Ifwat Mohd 
Published: May 2022

Abstract
In this work, the analysis of patch antenna design at the resonant frequency of 2.4 GHz and 3.5 GHz are presented. Both proposed antennas made of RT Duroid 5880 are designed and simulated using CST Studio Suite software. The antennas are designed, and their performances are examined. The antennas have been designed based on the size improvement technique to improve the fabrication tolerance. The characteristics of both antennas’ including return loss, radiation pattern, surface current and directivity or gain were compared. The optimization of patch measurement to achieve the desired resonant frequency were also displayed.
Model of galactic cosmic ray spectrum above the Earth’s atmosphere
Authors: Buchvarova M , Draganov D 
Published: May 2022

Abstract
Galactic cosmic ray transport in the heliosphere is described by the well-known Parker transport equation. In 1969, Fisk and Axford [1] presented approximate analytical solutions to the cosmic ray transport equation. One of their solutions was later used to construct useful semi-empirical models describing the energy spectra of charged particles during the solar cycle. In this paper, a simplified model of the galactic cosmic ray spectrum is presented. The model can be used to describe the galactic spectra of protons and helium nuclei during the 11-year solar cycle in interplanetary space at about 1 AU.
Ofine noise calibration of the CAEN V1742 ADCs at the PADME experiment
Authors: Georgiev for the PADME collaboration Georgi 
Published: May 2022

Abstract
This work aims to provide robust methods for ofine calibration of the noise foor for CAEN’s V1742 sampling ADCs, used at the PADME experiment. It has been found that a part of the noise in the fnal signals originates from not fully equalized storage capacitor properties in the DRS4 chip, even after application of the CAEN’s proprietary drs4 calibration. Two approaches to ofine equalization are discussed and fnally two methods are proposed for obtaining the calibration data from random and physics trigger runs.
PADME physics program
Authors: Simeonov Radoslav 
Published: May 2022

Abstract
The complete nature of the dark matter stays unsolved in the terms of the Standard Model. A possible solution suggests complete new class of particles which participate in interactions with Standard Model particles via newly introduced mediators, the so called portals. The Positron Annihilation into Dark Matter Experiment (PADME) aims to observe indirectly one of these portals — the dark photon A’, through the reaction e<sup>+</sup>+ e<sup>-</sup> —> γ + A’. Two data acquisition runs were already performed in order to study detectors behavior, background levels and mainly to throw light in the A’ mass region for 2 - 23.7 MeV/c .
Ventilated façade solutions
Authors: Baciu I-R , Isopescu D N , Lupu M L , Maxineasa S G , Pruna L , Dan S 
Published: May 2022

Abstract
Reducing the energy consumption needed for creating suitable indoor conditions has become a significant issue on a global scale. The building’s envelope and service systems have the most important influence over the amount of energy consumed. This aspect is related to reducing the heat flux across the building envelope in summer conditions and preventing the condensation and infiltration risk in the winter period. The research regarding ventilated façades has advanced taking into account these advantages, which emphasized the need to study and create constructive solutions adapted to the conditions. In this context, this paper represents a brief introduction to ventilated façades solutions, taking into account the definition, their characteristics, the principal constructive elements, the main types of ventilated facades, and last, but not least, their advantages and disadvantages. The authors believe that the study is critical in fully comprehending the characteristics of these systems and their primary components, as well as designing and implementing them in accordance with current environmental needs. It is anticipated that comprehending this concept, as well as its evolution and trends, can contribute in the resolving of a number of ecological and societal issues.
Study on quality detection of stone surface
Authors: Liu W , Zhao M , Shang H 
Published: May 2022

Abstract
With the continuous improvement for the safety of stone installation, the quality detection of its machined surface is also improving. But its surface crack was always a difficult problem in detection. In recent years, with the rapid development of image processing technology a new method to solve this problem can be realized. In this paper, CCD camera was used to detect the surface crack and roughness of stone slabs. The research about image correction and image enhancement was carried, so as to eliminate noise and protect the crack edge in the greatest extent. The improved threshold segmentation algorithm was used to segment image of linear fracture filtering. Mathematical morphology was applied to refinement of single pixel of crack in order to gain crack size. The CCD camera and micro lens are assembled as image sensors to enlarge the surface of stone and take a sample by many taking pictures. The surface profile of the tested stone slab is obtained by reconstruction method, and the surface roughness of stone slab is finally obtained by analysis and calculation. Through this research, a fast detection technology was realized, which solves the problems of low processing efficiency and high cost in production. The result shows certain theoretical value and practical application significance.
State-of-the-Art Review: Evidence on Red Meat Consumption and Hypertension Outcomes
Authors: Allen Tara Shrout , Bhatia Harpreet S , Wood Alexis C , Momin Shabnam R , Allison Matthew A 
Published: May 2022

AbstractHypertension (HTN) is a well-established risk factor for cardiovascular diseases (CVDs), including ischemic heart disease, stroke, heart failure, and atrial fibrillation. The prevalence of HTN, as well as mortality rates attributable to HTN, continue to increase, particularly in the United States and among Black populations. The risk of HTN involves a complex interaction of genetics and modifiable risk factors, including dietary patterns. In this regard, there is accumulating evidence that links dietary intake of red meat with a higher risk of poorly controlled blood pressure and HTN. However, research on this topic contains significant methodological limitations, which are described in the review. The report provided below also summarizes the available research reports, with an emphasis on processed red meat consumption and how different dietary patterns among certain populations may contribute to HTN-related health disparities. Finally, this review outlines potential mechanisms and provides recommendations for providers to counsel patients with evidence-based nutritional approaches regarding red meat and the risk of HTN, as well as CVD morbidity and mortality.
HOXA10 promote pancreatic cancer progression via directly activating canonical NF-κB signaling pathway
Authors: Li Jiao , Chang Jing , Wang Jinghan , Xu Dapeng , Yang Minwei , Jiang Yongsheng , Zhang Junfeng , Jiang Xiaohua , Sun Yongwei 
Published: May 2022

Abstract

Background
Although transcription factor homeobox A10 (HOXA10) plays an important role in regulating the development of the pancreas, a pathway of HOXA10 participates in pancreatic ductal adenocarcinoma (PDAC) progression has not been revealed.

Methods
Immunohistochemistry assays were applied to demonstrate the relationship between HOXA10 expression and PDAC progression. Functional assays were used to illustrate the oncogenic role of HOXA10 in PDAC progression. Regulatory mechanisms of HOXA10 induced IKKβ gene transcription and the nuclear transcription factor kappa B (NF-κB) signal pathways activation were also investigated in PDAC cells.

Results
In the current study, we show that HOXA10 expression increased in PDAC with higher tumor stage and poor patient survival in public RNA-seq data suggesting HOXA10 is associated with PDAC progression. HOXA10 promotes PDAC cell proliferation, anchorage colony formation, and xenograft growth by activating canonical NF-κB signaling both in vitro and in vivo. Mechanically, HOXA10 up-regulates IKKβ gene transcription directly and subsequently sustain the activation of NF-κB independent of tumor necrosis factor-alpha in PDAC cells.

Conclusion
Collectively, up-regulation of HOXA10 gene expression promote cell growth and tumor progression through directly activating canonical NF-κB signaling in PDAC.
Gestational age-related changes in the fetal functional connectome: in utero evidence for the global signal
Authors: Kim Jung-Hoon , De Asis-Cruz Josepheen , Cook Kevin M , Limperopoulos Catherine 
Published: May 2022

AbstractThe human brain begins to develop in the third gestational week and rapidly grows and matures over the course of pregnancy. Compared to fetal structural neurodevelopment, less is known about emerging functional connectivity in utero. Here, we investigated gestational age (GA)-associated in vivo changes in functional brain connectivity during the second and third trimesters in a large dataset of 110 resting-state functional magnetic resonance imaging scans from a cohort of 95 healthy fetuses. Using representational similarity analysis, a multivariate analytical technique that reveals pair-wise similarity in high-order space, we showed that intersubject similarity of fetal functional connectome patterns was strongly related to between-subject GA differences (r = 0.28, P &lt; 0.01) and that GA sensitivity of functional connectome was lateralized, especially at the frontal area. Our analysis also revealed a subnetwork of connections that were critical for predicting age (mean absolute error = 2.72 weeks); functional connectome patterns of individual fetuses reliably predicted their GA (r = 0.51, P &lt; 0.001). Lastly, we identified the primary principal brain network that tracked fetal brain maturity. The main network showed a global synchronization pattern resembling global signal in the adult brain.
Spatial transcriptomics unveils ZBTB11 as a regulator of cardiomyocyte degeneration in arrhythmogenic cardiomyopathy
Authors: Boogerd Cornelis J , Lacraz Grégory P A , Vértesy Ábel , van Kampen Sebastiaan J , Perini Ilaria , de Ruiter Hesther , Versteeg Danielle , Brodehl Andreas , van der Kraak Petra , Giacca Mauro , de Jonge Nicolaas , Junker Jan Philipp , van Oudenaarden Alexander , Vink Aryan , van Rooij Eva 
Published: May 2022

AbstractAimsArrhythmogenic cardiomyopathy (ACM) is an inherited cardiac disorder that is characterized by progressive loss of myocardium that is replaced by fibro-fatty cells, arrhythmias, and sudden cardiac death. While myocardial degeneration and fibro-fatty replacement occur in specific locations, the underlying molecular changes remain poorly characterized. Here, we aim to delineate local changes in gene expression to identify new genes and pathways that are relevant for specific remodelling processes occurring during ACM.Methods and resultsUsing Tomo-Seq, genome-wide transcriptional profiling with high spatial resolution, we created transmural epicardial-to-endocardial gene expression atlases of explanted ACM hearts to gain molecular insights into disease-driving processes. This enabled us to link gene expression profiles to the different regional remodelling responses and allowed us to identify genes that are potentially relevant for disease progression. In doing so, we identified distinct gene expression profiles marking regions of cardiomyocyte degeneration and fibro-fatty remodelling and revealed Zinc finger and BTB domain-containing protein 11 (ZBTB11) to be specifically enriched at sites of active fibro-fatty replacement of myocardium. Immunohistochemistry indicated ZBTB11 to be induced in cardiomyocytes flanking fibro-fatty areas, which could be confirmed in multiple cardiomyopathy patients. Forced overexpression of ZBTB11 induced autophagy and cell death-related gene programmes in human cardiomyocytes, leading to increased apoptosis.ConclusionOur study shows the power of Tomo-Seq to unveil new molecular mechanisms in human cardiomyopathy and uncovers ZBTB11 as a novel driver of cardiomyocyte loss.
Soil and water pollution and human health: what should cardiologists worry about?
Authors: Münzel Thomas , Hahad Omar , Daiber Andreas , Landrigan Philip J 
Published: May 2022

AbstractHealthy soil is foundational to human health. Healthy soil is needed to grow crops, provides food, and sustains populations. It supports diverse ecosystems and critical ecological services such as pollination. It stores water and prevents floods. It captures carbon and slows global climate change. Soil pollution is a great and growing threat to human health. Soil may be polluted by heavy metals, organic chemicals such as pesticides, biological pathogens, and micro/nanoplastic particles. Pollution reduces soil’s ability to yield food. It results in food crop contamination and disease. Soil pollutants wash into rivers causing water pollution. Deforestation causes soil erosion, liberates sequestered pollutants, and generates airborne dust. Pollution of air, water, and soil is responsible for at least 9 million deaths each year. More than 60% of pollution-related disease and death is due to cardiovascular disease. Recognizing the importance of pollution to human health, the European Commission and the EU Action Plan for 2050: A Healthy Planet for All, have determined that air, water, and soil pollution must be reduced to levels that cause no harm to human or ecosystem health. We are thus required to create a toxic-free environment, respect the concept of a safe operating space for humanity, and sustain the health of our planet for future generations. This review article summarizes current knowledge of the links between soil health and human health and discusses the more important soil pollutants and their health effects.
Targeted temperature management after out of hospital cardiac arrest: quo vadis?
Authors: Krychtiuk Konstantin A , Fordyce Christopher B , Hansen Carolina M , Hassager Christian , Jentzer Jacob C , Menon Venu , Perman Sarah M , van Diepen Sean , Granger Christopher B 
Published: May 2022

AbstractTargeted temperature management (TTM) has become a cornerstone in the treatment of comatose post-cardiac arrest patients over the last two decades. Belief in the efficacy of this intervention for improving neurologically intact survival was based on two trials from 2002, one truly randomized-controlled and one small quasi-randomized trial, without clear confirmation of that finding. Subsequent large randomized trials reported no difference in outcomes between TTM at 33 vs. 36°C and no benefit of TTM at 33°C as compared with fever control alone. Given that these results may help shape post-cardiac arrest patient care, we sought to review the history and rationale as well as trial evidence for TTM, critically review the TTM2 trial, and highlight gaps in knowledge and research needs for the future. Finally, we provide contemporary guidance for the use of TTM in daily clinical practice.