bluuebunny/crossref_metadata_2025_split huggingface dataset:
Multifaceted amelioration of cutaneous photoageing by (0.3%) retinol
Authors: Mellody Kieran T. , Bradley Eleanor J. , Mambwe Bezaleel , Cotterell Lindsay F. , Kiss Orsolya , Halai Poonam , Loftus Zeena , Bell Mike , Griffiths Tamara W. , Griffiths Christopher E. M. , Watson Rachel E. B. 
Published: July 2022

AbstractBackgroundAlthough retinol skin care products improve the appearance of photoaged skin, there is a need for an effective retinol concentration that provides skin benefits without irritation.ObjectiveTo compare the efficacy of topical 0.1%, 0.3% and 1% retinol in remodelling the cutaneous architecture in an in vivo experimental patch test study, and to determine tolerance of the most effective formulations when used in a daily in‐use escalation study.MethodsFor the patch test study, retinol products were applied under occlusion, to the extensor forearm of photoaged volunteers (n = 5; age range 66–84 years), and 3 mm skin biopsies obtained after 12 days. Effects of different retinol concentrations, and a vehicle control, on key epidermal and dermal biomarkers of cellular proliferation and dermal remodelling were compared to untreated baseline. Separately, participants (n = 218) recorded their tolerance to 0.3% or 1% retinol over a six‐week, approved regimen, which gradually increased the facial applications to once nightly.ResultsRetinol treatment induced a stepwise increase in epidermal thickness and induced the expression of stratum corneum proteins, filaggrin and KPRP. 0.3% retinol and 1% retinol were comparably effective at inducing keratinocyte proliferation in the epidermis, whilst reducing e‐cadherin expression. Fibrillin‐rich microfibril deposition was increased following treatment with 0.3% and 1% retinol (p < 0.01); other dermal components remained unaltered (e.g., fibronectin, collagen fibrils, elastin), and no evidence of local inflammation was detected. The in‐use study found that 0.3% retinol was better tolerated than 1% retinol, with fewer and milder adverse events reported (χ2(1) = 23.97; p < 0.001).ConclusionsThis study suggests that 1% and 0.3% retinol concentrations were similarly effective at remodelling photodamaged skin in an in vivo model of long‐term use. Use of 0.3% retinol in the escalation study was associated with fewer adverse reactions when applied daily. Hence, 0.3% retinol may be better tolerated than 1% retinol, thereby allowing longer‐term topical application.
I'll have what she's having: (Social) Perceptions of default options and implications for marketing and decision making
Authors: Buchanan Tonya M. , Buchanan Joshua , Diedericks Dené , Davis Logan 
Published: July 2022

AbstractThe power that default options have in shaping choice has been well established, yet relatively little is known about how decision makers experience and interpret such preselected options. Research suggests that individuals assume defaults represent a recommended course of action, yet the basis for this recommendation is unclear. Across two experimental studies, we explored consumer theories of default recommendations, examining spontaneous and experimentally manipulated perceptions of the basis of the default, and the impact on decision making across different contexts. Evidence across diverse populations and tasks shows that options were retained to a greater extent when represented as the default, consistent with classic default effects. Furthermore, a significant default effect emerged when the decision context was framed as complex. In line with research on social influence, defaults were most effective when they were presumed to reflect the most popular option (regardless of context). Interestingly, participants rated defaults as being more likely to represent the most popular option, regardless of decision context or default explanation provided to them. These findings highlight the importance of understanding the contexts in which default choices are relied upon and how those defaults are perceived by decision makers.
Effect of flaxseed oil double emulsion with tea polyphenol on the gel characteristics, antioxidant property and water mobility in reduced‐fat pork batter
Authors: Li Yan‐ping , Bai Rong , Feng Liang , Kang Zhuang‐Li , Xu Gui‐hua , Ma Han‐Jun 
Published: July 2022

SummaryThe changes in gel characteristics, rheology and antioxidant properties, microstructure and water mobility were studied to investigate the potential use of flaxseed oil double emulsion to replace pork back‐fat (25%, 50%, 75% and 100%) in reduced‐fat pork batter. The flaxseed oil double emulsion (pH 6.0) was made of 20 mL 0.5% tea polyphenol solution (w/w), 20 mL flaxseed oil, 60 mL 4% whey protein (w/w) and 400 mL 2% Arabic gum solution. The result showed that the TBARS, L*, and a* values of pork batter significantly decreased (P < 0.05) when the flaxseed oil double emulsion replacing the pork back‐fat was ≤50%. Meanwhile, the pH, emulsification stability, hardness, springiness, gumminess, chewiness, cooking yield and G′ at 80 °C significantly increased (P < 0.05). In addition, the mobility of water in cooked batter first decreased and then increased (P < 0.05) with increasing flaxseed oil double emulsion. In addition, the microstructure of cooked pork batter with 50% flaxseed oil double emulsion has a continuous, tighter and regular structure, with the pores being smaller and more uniform. Overall, the replacement of pork back‐fat with flaxseed oil double emulsion at 50% reduced‐fat content could improve the quality of pork batter.
Conditional knockout of oestrogen receptor alpha in CD11c+ cells impacts female survival and inflammatory cytokine profile in murine lupus
Authors: Lennard Richard Mara L. , Wirth Jena R. , Khatiwada Aastha , Chung Dongjun , Gilkeson Gary S. , Cunningham Melissa A. 
Published: July 2022

AbstractOestrogen and oestrogen receptor alpha (ERα) have been implicated in systemic lupus erythematosus pathogenesis. ERα signalling influences dendritic cell (DC) development and function, as well as inflammation and downstream immune responses. We previously reported that ERα modulates multiple Toll‐like receptor‐stimulated pathways in both conventional and plasmacytoid DCs in lupus‐prone mice. For example, CD11chiMHCII+ cell numbers are reduced in mice with global ERα deficiency or when expressing a short variant of ERα. Herein, RNA‐seq analysis of CD11chi cells from bone marrow of NZM2410 mice expressing WT ERα versus ERα short versus ERα null revealed differentially expressed complement genes, interferon‐related genes and cytokine signalling (e.g., IL‐17 and Th17 pathways). To better understand the role of ERα in CD11c+ cells, lupus prone NZM2410 mice with selective deletion of the Esr1 gene in CD11c+ cells were generated. Phenotype and survival of these mice were similar with the exception of Cre positive (CrePos) female mice. CrePos females, but not males, all died unexpectedly prior to 35 weeks. DC subsets were not significantly different between groups. Since ERα is necessary for robust development of DCs, this result suggests that DC fate was determined prior to CD11c expression and subsequent ERα deletion (i.e., proximally in DC ontogeny). Overall, findings point to a clear functional role for ERα in regulating cytokine signalling and inflammation, suggesting that further study into ERα‐mediated regulatory mechanisms in DCs and other immune cell types is warranted.
How does the volatility‐timing strategy perform in mutual funds portfolios
Authors: Yin Zhida , Jiang Jilin , Qian Zongxin 
Published: July 2022

AbstractLiterature suggests that a volatility‐timing strategy improves the performance of factor portfolios in the stock market and currency carry trade. This paper shows that the performance of this strategy is mixed when applied to mutual fund portfolios. More specifically, its performance not only depends on the investment style of the mutual funds but also the time periods when it is applied.
Effect of manual lymphatic drainage combined with vacuum sealing drainage on axillary web syndrome caused by breast cancer surgery
Authors: Liu Jingyi , Chen Di , Yin Xiaoting 
Published: July 2022

AbstractThe aim of the study was to explore the application value of manual lymphatic drainage combined with vacuum sealing drainage in axillary web syndrome (AWS) after breast cancer surgery. From 1 April 2020 to 1 June 2020, a total of 102 patients with AWS after axillary lymph node biopsy or axillary lymph node dissection in our hospital were included in this prospective study. According to the random number table method, all patients were divided into the study group (n = 51) and the control group (n = 51). The study group received the treatment of manual lymphatic drainage combined with vacuum sealing drainage, and the control group received health education and the treatment of functional training. The efficacy observation indicators included duration time to the disappearance of relevant clinical symptoms, degree of pain, angle of abduction of the affected limb, degree of upper limb disability function and quality of life. The duration time to the disappearance of cord‐like nodules and tightness in the study group was both significantly shorter than that in the control group (both P < .05). In the time point of 1 and 3 months after the intervention, compared with that in the control group, the study group had a significantly lighter degree of pain, a better degree of upper limb disability function and higher quality of life (all P < .05). Manual lymphatic drainage combined with vacuum sealing drainage can shorten the disappearance time of relevant clinical symptoms, relieve the degree of pain, improve the upper limb disability function and improve the quality of life in patients with AWS.
Is the Freedom to Bequeath a Basic Liberty?
Authors: Berrotarán Alejandro 
Published: July 2022

ABSTRACTWhy should we recognize people's freedom to bequeath? In this article, I argue that bequeathing should be considered a basic liberty within John Rawls' scheme of justice. To do so, I begin by identifying the characteristics of the interests protected by the basic liberties. These interests are linked to the exercise or development of the two moral powers of persons, must belong to the holder of the right or freedom, and can only be limited by the externalities arising from the exercise of other fundamental interests. Subsequently, I address whether the interest covered by the right to bequeath meets these criteria. Finally, I conclude by establishing that the power to bequeath is a basic liberty that protects the interest of its holder in being partial and that can only be limited if its exercise undermines other fundamental liberties.
On the importance of parenting in externalizing disorders: an evaluation of indirect genetic effects in families
Authors: Eilertsen Espen M. , Cheesman Rosa , Ayorech Ziada , Røysamb Espen , Pingault Jean‐Baptiste , Njølstad Pål R. , Andreassen Ole A. , Havdahl Alexandra , McAdams Tom A. , Torvik Fartein A. , Ystrøm Eivind 
Published: July 2022

BackgroundTheoretical models of the development of childhood externalizing disorders emphasize the role of parents. Empirical studies have not been able to identify specific aspects of parental behaviors explaining a considerable proportion of the observed individual differences in externalizing problems. The problem is complicated by the contribution of genetic factors to externalizing problems, as parents provide both genes and environments to their children. We studied the joint contributions of direct genetic effects of children and the indirect genetic effects of parents through the environment on externalizing problems.MethodsThe study used genome‐wide single nucleotide polymorphism data from 9,675 parent–offspring trios participating in the Norwegian Mother Father and child cohort study. Based on genomic relatedness matrices, we estimated the contribution of direct genetic effects and indirect maternal and paternal genetic effects on ADHD, conduct and disruptive behaviors at 8 years of age.ResultsModels including indirect parental genetic effects were preferred for the ADHD symptoms of inattention and hyperactivity, and conduct problems, but not oppositional defiant behaviors. Direct genetic effects accounted for 11% to 24% of the variance, whereas indirect parental genetic effects accounted for 0% to 16% in ADHD symptoms and conduct problems. The correlation between direct and indirect genetic effects, or gene–environment correlations, decreased the variance with 16% and 13% for conduct and inattention problems, and increased the variance with 6% for hyperactivity problems.ConclusionsThis study provides empirical support to the notion that parents have a significant role in the development of childhood externalizing behaviors. The parental contribution to decrease in variation of inattention and conduct problems by gene–environment correlations would limit the number of children reaching clinical ranges in symptoms. Not accounting for indirect parental genetic effects can lead to both positive and negative bias when identifying genetic variants for childhood externalizing behaviors.
Evolutionary bioenergetics of ciliates
Authors: Lynch Michael , Schavemaker Paul E. , Licknack Timothy J. , Hao Yue , Pezzano Arianna 
Published: July 2022

AbstractUnderstanding why various organisms evolve alternative ways of living requires information on both the fitness advantages of phenotypic modifications and the costs of constructing and operating cellular features. Although the former has been the subject of a myriad of ecological studies, almost no attention has been given to how organisms allocate resources to alternative structures and functions. We address these matters by capitalizing on an array of observations on diverse ciliate species and from the emerging field of evolutionary bioenergetics. A relatively robust and general estimator for the total cost of a cell per cell cycle (in units of ATP equivalents) is provided, and this is then used to understand how the magnitudes of various investments scale with cell size. Among other things, we examine the costs associated with the large macronuclear genomes of ciliates, as well as ribosomes, various internal membranes, osmoregulation, cilia, and swimming activities. Although a number of uncertainties remain, the general approach taken may serve as blueprint for expanding this line of work to additional traits and phylogenetic lineages.
Implementing precision medicine in endoscopy practice
Authors: Kuo Chen‐Ya , Wu Jer‐Wei , Yeh Jen‐Hao , Wang Wen‐Lun , Tu Chia‐Hung , Chiu Han‐Mo , Liao Wei‐Chih 
Published: July 2022

AbstractIn contrast to the “one‐size‐fits‐all” approach, precision medicine focuses on providing health care tailored to individual variabilities. Implementing precision medicine in endoscopy practice involves selecting the appropriate procedures among the endoscopic armamentarium in the diagnosis and management of patients in a logical sequence, jointly considering the pretest probabilities of possible diagnoses, patients' comorbidities and preference, and risk–benefit ratio of the individual procedures given the clinical scenario. The aim of this review is to summarize evidence‐supported strategies and measures that may enhance precision medicine in general endoscopy practice.
Saffron and retinal neurodegenerative diseases: Relevance of chemical composition
Authors: Maggi Maria A. , Consonni Roberto , Cagliani Laura R. , Prestipino Gianfranco , Bisti Silvia , Picco Cristiana 
Published: July 2022

AbstractSaffron is an ancient spice largely used in traditional medicine. It has been found to be effective in treatment of retinal neurodegenerative diseases like age‐related macular degeneration and Stargardt. In the present manuscript, it is shown that saffron’s neuroprotective power is strongly related to the bioactivity of all its chemical components. Nuclear magnetic resonance spectroscopy and “in vitro” experiments confirm the relevance of crocins for saffron efficacy. These results underline the importance of strictly defining the chemical composition of the natural compounds in saffron to optimize their effectiveness in the treatment of diseases.
Involving families in the care of Indigenous infants: A philosophical exploration of Indigenous ways of knowing to inform nursing research and practice in the neonatal intensive care unit
Authors: Carrier Leah , Dame Jessy , Wright Amy L. , Latimer Margot 
Published: July 2022

AbstractAims and objectivesTo explore the use of Indigenous philosophies and ways of knowing as a means to critique, understand and improve the care of Indigenous infants and families in the neonatal intensive care unit (NICU).BackgroundThe ability of health professionals to provide culturally safe and equitable care to Indigenous infants and their families can affect infant development and long‐term health outcomes. Research suggests that family involvement in care benefits both the infant and their family, but there is limited research that addresses the experience of Indigenous families in the NICU and advances understanding of how nurses involve Indigenous families in their infants' care.DesignA discursive, critical review will be presented to outline the assumptions of Indigenous philosophies and to explore how the consideration and implementation of Indigenous ways of knowing can improve the nursing care of Indigenous infants and their families in the NICU.MethodFirst, our subjective positioning as Indigenous nurses and as health researchers is described. Second, our understanding of Indigenous philosophical frameworks and how these approaches fit in the context of the philosophy of science is defined. Third, the key elements of an Indigenous philosophical paradigm are described. Fourth, an application of Indigenous paradigms to supporting the care of Indigenous infants and families in the NICU context is made.ConclusionsAn Indigenous philosophical approach to nursing is ideal for understanding and improving the experiences of Indigenous infants and families in the NICU. This approach allows nurses to critically analyse the history and legacy of colonialism and its impact on the health and wellbeing of Indigenous peoples. By prioritising the voices and concerns of Indigenous families in the clinical setting and in nursing research, nurses can better understand the experiences of these families in the NICU and use strengths‐based approaches to facilitate family involvement in care.Relevance to clinical practiceThe application of Indigenous philosophies in the nursing context can be used to inform the care of Indigenous infants and families in the NICU. Potential benefits include improved therapeutic relationships between nurses and Indigenous families, and increased uptake of parent‐led interventions in nursing practice, which may lead to improved health outcomes for Indigenous infants in the NICU and throughout their subsequent development.
Systematic review and meta‐analysis of randomization controlled and nonrandomized controlled studies on nurse‐led nonpharmacological interventions to improve cognition in people with dementia
Authors: Suh Yujin , Lee Sumi , Kim Go‐Eun , Lee JuHee 
Published: July 2022

AbstractAims and objectivesTo evaluate nurse‐led nonpharmacological interventions for improving cognition in people with dementia.BackgroundStarting in 2006, donepezil was administered worldwide to improve cognition; however, its side effects limited its therapeutic value for long‐term use, prompting a need for nonpharmacological interventions to improve cognition. Nurse‐led nonpharmacological interventions are especially important because they are effective in terms of resources and costs, reduce patient latency and improve patient safety and satisfaction.MethodsA systematic review was identified by searching 10 electronic databases. The search period was between 1 January 2007, and 30 September 2021. Languages were limited to English and Korean. The inclusion criteria were studies of nurse‐led interventions that evaluated cognition using validated instruments. The exclusion criteria were qualitative research, scale development studies, abstracts and grey literature. Quality appraisal of research was conducted using the Risk of Bias in Nonrandomized Studies of Interventions for quasi‐experimental studies and the Risk of Bias 2.0 for randomised controlled studies. This study was conducted in accordance with PRISMA reporting guideline (Appendix S1). The search protocol was registered in the PROSPERO (CRD 42021229358).ResultsA total of 24 studies were included in the systematic review, and 15 studies were included in the meta‐analysis. Meta‐analysis included 8 RCT and 7 quasi‐experimental studies. The studies (11 quasi‐experimental studies and 9 randomised controlled studies) demonstrated low to moderate quality of evidence for improving the cognition of people with dementia. The meta‐analysis showed that nurse‐led single nonpharmacological interventions more effectively improved cognition than complex interventions in people with dementia.ConclusionNurse‐led nonpharmacological interventions were effective for improving cognition in people with dementia.Relevance to clinical practiceNurses are qualified professionals with expertise in providing nonpharmacological interventions to improve cognition in people with dementia. Nurse‐led nonpharmacological interventions for this purpose should be developed in future research.
Clinical characteristic and prognostic factors in high‐grade endometrial neuroendocrine carcinoma
Authors: Zhang Zhifang , Wang Jing , Wu Xiaomei , Liu Yuan , Xi Xiaowei 
Published: July 2022

AbstractAimThe aim of the present study was to summarize the clinical characteristics and analyze the independent prognostic factors in patients with high‐grade endometrial neuroendocrine carcinoma (ENC).MethodsPatients diagnosed with ENC, endometrioid adenocarcinoma (EAC), endometrial clear‐cell carcinoma (ECC), endometrial serous carcinoma (ESC), endometrioid carcinoma with mucinous features (EMC) from 1987 to 2016 were screened from the National Cancer Institute database (surveillance, epidemiology, and end results [SEER]). Kaplan–Meier were used to assess survival. Univariate and multivariate Cox proportional hazards analysis were done to examine factors affecting survival.ResultsThe median survival times of ENC were 11 months, shorter than that of EAC, ECC, ESC, and EMC (p < 0.01). There was no significant difference in ages, survival rate, and median survival time between large‐cell ENC (LCENC) and small‐cell ENC (SCENC), which were all belong to ENC. In a multivariable model, the hazard ratio (HR) of death for women with Federation International of Gynecology and Obstetrics (FIGO) stage I‐II of ENC was 0.37 compared to FIGO stage III‐IV (p < 0.01). The HR of patients who under the surgery was 0.39 compared to the patients who without surgery (p < 0.01), and the HR of patients who received chemotherapy was 0.51 compared to the patients who did not received chemotherapy (p < 0.01). Radiotherapy did not significantly reduce the mortality risk of patients.ConclusionENC was a kind of devastating endometrial cancers with the poorest prognosis. Surgical treatment and chemotherapy were necessary for improving prognosis of ENC. Early diagnosis favored better prognosis. There was no prognostic difference between with and without radiotherapy.