bluuebunny/crossref_metadata_2025_split huggingface dataset:
Attention to Progression Principles and Variables of Exercise Prescription in Workplace-Related Resistance Training Interventions: A Systematic Review of Controlled Trials
Authors: Stassen Gerrit , Baulig Lukas , Müller Ole , Schaller Andrea 
Published: March 2022

BackgroundThe workplace is an important setting for adult health promotion including exercise training such as resistance training (RT). Since the reporting of exercise training interventions is generally inconsistent, the objective of this systematic review was to investigate the attention to principles of RT progression and variables of RT exercise prescription in workplace-related RT interventions.MethodsA systematic literature search was conducted in the databases LIVIVO, PubMed, SPORTDiscus, and Web of Science (2000–2020). Controlled trials with apparently healthy “employees” and a main focus on RT were included. RT principles and variables were extracted and rated by two reviewers (reported, not reported, or unclear). Sum scores for each RT intervention and percentages regarding each principle and variable were calculated.ResultsOverall, 21 articles were included (18 primary studies, 3 protocols). Summarized narratively, the interventions showed different positive effects on strength- or performance-related and/or health- or complaint-related outcomes. The reporting of the RT principles and variables was varied [progressive overload: 94% of the studies, specificity: 78%, variation (periodization): 39%, muscle action: 94%, loading: 94%, volume; 67%, exercise selection: 89%, exercise order: 47%, rest periods between sets: 33%, rest periods between exercises: 27%, repetition velocity: 44%, and frequency: 100%].ConclusionSeveral key RT principles and variables were reported inconsistently, reducing reproducibility and pointing to the need for standardized RT intervention reporting in workplace-related interventions. Exercise science and workplace promotion should be further linked, since accurate reporting is a prerequisite for transferring robust findings into practice.
The Effect of Rifle Carriage on the Physiological and Accelerometer Responses During Biathlon Skiing
Authors: Staunton Craig A. , Sloof Luciën , Brandts Maxime , Jonsson Kårström Malin , Laaksonen Marko S. , Björklund Glenn 
Published: March 2022

PurposeInvestigate the effect of biathlon rifle carriage on physiological and accelerometer-derived responses during biathlon skiing.MethodsTwenty-eight biathletes (11F, 17M) completed two XC skiing time-trials (~2,300 m), once with and once without the biathlon rifle, with concurrent measurements of HR, skiing speed and accelerations recorded from three triaxial accelerometers attached at the Upper-spine, Lower-spine and Pelvis. Exercise intensity was quantified from HR, skiing speed as well from accelerometry-derived PlayerLoad™ per minute (PL·min−1) and average net force (AvFNet). All metrics were analyzed during Uphill, Flat and Downhill sections of the course. Relationships between accelerometry-derived metrics and skiing speed were examined.ResultsTime-trials were faster for males compared with females (mean difference: 97 ± 73 s) and No-Rifle compared to With-Rifle (mean difference: 16 ± 9 s). HR was greatest during Downhill (183 ± 5 bpm), followed by Uphill (181 ± 5 bpm) and was lowest in the Flat sections (177 ± 6 bpm, p &lt;0.05). For PL·min−1 and AvFNet there were 3-way Rifle x Gradient x Sensor-Position interactions. Typically, these metrics were greatest during Uphill and Flat sections and were lowest during Downhill sections. Rifle carriage had no impact on the AvFNet at the Lower-Spine or Pelvis. Significant positive linear relationships were identified between skiing speed and accelerometer-derived metrics during Uphill, Flat and Downhill skiing (r = 0.12–0.61, p &lt; 0.05).ConclusionsThe accelerometry-derived approach used in this study provides the potential of a novel method of monitoring the external demands during skiing. In particular, AvFNet with sensors located close to the center of mass displayed greatest utility because it followed the expected response of external intensity where responses were greatest during uphill sections, followed by flats and lowest during downhills. In addition, there were significant positive relationships between AvFNet and skiing speed ranging from small to large. Accelerometry-derived measures could provide useful estimates of the external demands in XC skiing and biathlon.
Minimally Invasive Isolated Tricuspid Valve Repair After Left-Sided Valve Surgery: A Single-Center Experience
Authors: Dai Xiaoyi , Teng Peng , Miao Sihan , Zheng Junnan , Si Wei , Zheng Qi , Qin Ke , Ma Liang 
Published: March 2022

BackgroundTricuspid regurgitation after left-sided valve surgery was associated with terrible outcomes and high perioperative mortality for surgical treatment. In current years, minimally invasive isolated tricuspid valve repair is increasingly performed in our institution to address tricuspid regurgitation.MethodsThirty-seven consecutive patients with previous left-sided valve surgery underwent minimally invasive isolated tricuspid valve repair in our institution between November 2017 and December 2020. Twenty-nine patients(78.4%) were women and the mean age of patients was 58.4 ± 8.5 years. Follow-up was 100% complete with a mean follow-up time of 17.2 ± 9.5 months.ResultsBoth the in-hospital and 30-day mortalities were 2.7%. The overall NYHA class had improved significantly during the follow-up (p &lt; 0.001). The grade of TR had decreased before discharge (p &lt; 0.001) and during the follow-up (p &lt; 0.001) compared with the preoperative level although severe TR was recurrent in one patient.ConclusionsMinimally invasive isolated tricuspid valve repair has acceptable early and midterm outcomes, may be the preferred surgical option to address tricuspid regurgitation after previous left-sided valve surgery when it is feasible.
Case Report: Reconstruction of Medialis Malleolus (1/4 of the Ankle Joint) After Resection of Distal Tibia Tumor With an Uncemented Three-Dimensional-Printed Prosthesis
Authors: Wang Shang , Luo Yi , Zhang Yuqi , Wang Yitian , Zheng Chuanxi , Tu Chongqi , Zhou Yong 
Published: March 2022

IntroductionFew patients presented with a distal tibial tumor that only invaded a small area of bone in the medial malleolus. There have been no previous cases in which only the medial or lateral malleolus was removed and reconstruction was complete. This article describes our attempt to reconstruct the medial malleolus (1/4 of the ankle joint) after resection of a distal tibial tumor with an uncemented three-dimensional (3D)-printed prosthesis.Case DescriptionA 39-year-old man presented with a lump in the right medial malleolus, and biopsy results suggested fibrosarcoma. To preserve the patient's normal bone and function, we only removed the medial malleolus and reconstructed the ankle joint using a personalized 3D-printed prosthesis. The patient had no complications other than necrosis of the skin flap that covered the wound. The patient recovered well after undergoing an additional skin flap transfer. Follow-up at 7 months and again at 3 years after surgery showed good ankle function and stability, with no pain or complications.ConclusionThe 3D-printed partial ankle prosthesis had a good matching degree, strength, and osseointegration ability, but also had a few complications. The patient achieved satisfactory ankle function and stability. However, a longer follow-up period is needed, and more research is required to confirm the efficacy of the prosthesis.
Correlation Between Hypothyroidism During Pregnancy and Glucose and Lipid Metabolism in Pregnant Women and Its Influence on Pregnancy Outcome and Fetal Growth and Development
Authors: Xu Da , Zhong Haolin 
Published: March 2022

Purpose:To observe the correlation between hypothyroidism during pregnancy and glucose and lipid metabolism in pregnant women and its influence on a pregnancy outcome and fetal growth and development.MethodsAbout 152 patients with hypothyroidism during pregnancy in our hospital from June 2017 to June 2020 were selected as the observation group and divided into the overt hypothyroidism (OH) group, the subclinical hypothyroidism (SCH) group, and the low T4 group. Another 60 pregnant women with normal antenatal examination and normal thyroid function were selected as the normal group. The glucose and lipid metabolism indexes of each group were compared. The pregnant women in the OH group and the SCH group were given levothyroxine intervention, and the pregnancy outcome and infant development of the two groups were compared.ResultsThe fasting blood glucose and hemoglobin A1c, triglyceride and low-density lipoprotein of the OH group and the SCH group were higher than the low T4 group and the normal group, and the OH group was higher than the SCH group (p &lt; 0.05). The incidence of premature delivery and premature rupture of membranes at term (PROM at term) in the hypothyroidism non-control group was higher than the hypothyroidism control group (p &lt; 0.05). The mental development index and the psychomotor development index in the hypothyroidism non-control group were lower than the hypothyroidism control group (p &lt; 0.05).ConclusionPregnant women with hypothyroidism during pregnancy are more prone to glucose and lipid metabolism disorder, which increases the risk of premature delivery and PROM at term, and has certain influence on the intellectual development and psychomotor development of infants.
The Minimally Invasive Star-Shaped Incision Technique and the Linear Incision Technique With Tissue Preservation for Percutaneous Bone Conduction Devices: A Retrospective Cohort Study
Authors: Strijbos Ruben M. , Salameh Samer , Bezdjian Aren , Daniel Sam J. , Thomeer Hans GXM. 
Published: March 2022

PurposeTo compare intra- and postoperative outcomes between the standard linear incision technique with tissue preservation (LITT-P) and the minimally invasive star-shaped incision (SSI).Study DesignA retrospective cohort study.MethodsPrimary outcomes evaluated operative time, implant survival, and intra-operative complications. A secondary outcome evaluated soft tissue tolerability assessed by the Holger's classification.ResultsA total of 38 implants were placed (19 LITT-P; 19 SSI). The median and mean surgical duration for the LITT-P group was statistically shorter than the SSI group (p = 0.0001). No intra-operative complications were reported for both surgical approaches. Five implants were lost during postoperative follow-up: one in the LITT-P and four in the SSI cohort. Both cohorts showed favorable soft tissue tolerability. Less Holgers 1 and 2 and more Holgers 3 soft tissue reactions were observed after the LITT-P compared to the SSI.ConclusionThe novel SSI approach could be an alternative option based on the theoretical benefits and found favorable (and similar) soft tissue outcomes. Implant loss and surgical time are aspects to investigate regarding long-term durability and warrant further research.
Identification of Potential Molecular Mechanism Related to Infertile Endometriosis
Authors: Li Xiushen , Guo Li , Zhang Weiwen , He Junli , Ai Lisha , Yu Chengwei , Wang Hao , Liang Weizheng 
Published: March 2022

ObjectivesIn this research, we aim to explore the bioinformatic mechanism of infertile endometriosis in order to identify new treatment targets and molecular mechanism.MethodsThe Gene Expression Omnibus (GEO) database was used to download MRNA sequencing data from infertile endometriosis patients. The “limma” package in R software was used to find differentially expressed genes (DEGs). Weighted gene co-expression network analysis (WGCNA) was used to classify genes into modules, further obtained the correlation coefficient between the modules and infertility endometriosis. The intersection genes of the most disease-related modular genes and DEGs are called gene set 1. To clarify the molecular mechanisms and potential therapeutic targets for infertile endometriosis, we used Gene Ontology (GO), Kyoto Gene and Genome Encyclopedia (KEGG) enrichment, Protein-Protein Interaction (PPI) networks, and Gene Set Enrichment Analysis (GSEA) on these intersecting genes. We identified lncRNAs and miRNAs linked with infertility and created competing endogenous RNAs (ceRNA) regulation networks using the Human MicroRNA Disease Database (HMDD), mirTarBase database, and LncRNA Disease database.ResultsFirstly, WGCNA enrichment analysis was used to examine the infertile endometriosis dataset GSE120103, and we discovered that the Meorangered1 module was the most significantly related with infertile endometriosis. The intersection genes were mostly enriched in the metabolism of different amino acids, the cGMP-PKG signaling pathway, and the cAMP signaling pathway according to KEGG enrichment analysis. The Meorangered1 module genes and DEGs were then subjected to bioinformatic analysis. The hub genes in the PPI network were performed KEGG enrichment analysis, and the results were consistent with the intersection gene analysis. Finally, we used the database to identify 13 miRNAs and two lncRNAs linked to infertility in order to create the ceRNA regulatory network linked to infertile endometriosis.ConclusionIn this study, we used a bioinformatics approach for the first time to identify amino acid metabolism as a possible major cause of infertility in patients with endometriosis and to provide potential targets for the diagnosis and treatment of these patients.
President’s Message for the inaugural edition of the ISAK Journal
Authors: Mike Marfell-Jones 
Published: March 2022

It is with both pleasure and pride that ISAK announces the first edition of the International Journal of Kinanthropometry which will showcase research in the area of Anthropometry and its applications. Other than in this first issue, where contributions have been by invitation and evaluated for acceptability by the editorial team, the journal will only publish refereed scientific papers plus research reviews and case studies.
You will see that we have an interesting selection of papers for you to read and I thank all contributors for both their research and their willingness to share it with us.
The journal marks yet another significant milestone in ISAK’s development and will stand or fall on both the quantity and quality of papers submitted. Although we anticipate that the majority of papers submitted will come from ISAK members, it is not a requirement that submitters and/or co-authors be members of ISAK.
Our sincere gratitude for this production goes to the Journal’s Editor-in-Chief, Dr Anup Adhikari and the publication team led by Dr Babu Balraj from IOR Press.
The Main Aspects of Pharmaceutical Assistance in the Sale of Anthelmintic Medicines
Authors: Кирилюк А.А. 
Published: March 2022

По данным ВОЗ, гельминтозы занимают третье место в структуре инфекционных заболеваний. Рост заболеваемости обусловлен сбросом сточных вод в поверхностные водные объекты или непосредственно на землю, повышением миграции населения из стран с теплым климатом, увеличение численности домашних животных. В последнее время получена информация о развивающейся у гельминтов устойчивости к лекарственным средствам. В первой части статьи приводится понятие и классификация гельминтов, систематизирована информация о клинической картине наиболее часто встречающихся гельминтозов. Вторая часть посвящена 17 противогельминтным лекарственным средствам, зарегистрированным в Республике Беларусь. Приводится актуальная и систематизированная информация о показаниях и противопоказаниях по применению, побочных реакциях и лекарственных взаимодействиях с позиции причинно-следственных связей, опирающихся на фармакодинамические и фармакокинетические особенности лекарственных средств. Приведен алгоритм оказания фармацевтическим работником грамотной фармацевтической помощи (в т. ч. фармацевтического консультирования) посетителю, обратившемуся в аптеку с вопросом о приобретении противогельминтных средств.
Аccording to WHO, helminthiases rank the third place in the structure of infectious diseases. In addition, the increasing of the incidence is due to the discharge of wastewater into other water bodies or onto the ground, an increasing the population migration from countries with a warm climate, and an increasing the number of domestic animals. The increase of morbidity of helminthiasis is associated with the discharge of wastewater into other water objects or onto the ground, the migration of people from countries with a warm climate, and the large number of domestic animals. Recently the reports about helminths with drug resistance are received. In the first part, the concept and classification of helminths is given, and clinical information on the most common helminthiases is systematized. The second part of the article is devoted to 17 anthelmintic medicines that are registered in the Republic of Belarus. Actual and systematic information about medical uses and contraindications, adverse reactions and drug interactions were systematizedaccording to pharmacodynamic and pharmacokinetic of medicines, and cause-effect relationships. An algorithm of pharmaceutical consulting has been developed to help pharmacists give advices to a visitor with helminthiasis.
The Role of Vitamin D in High Cardiovascular Risk Hypertension
Authors: Гончар К.В. , Якубова Л.В. 
Published: March 2022

Представлен обзор литературных данных по влиянию витамина D на состояние пациентов с артериальной гипертензией, сочетающейся с ожирением и дислипидемией. Описаны потенциальные механизмы, благодаря которым витамин D может влиять на сосудистую стенку, функцию эндотелия, уровень холестерина и липопротеинов низкой плотности, толерантность к глюкозе, уровень инсулина и чувствительность к нему, количество рецепторов к инсулину, участвовать в процессах воспаления. Представлены результаты исследований, описывающих эффекты приема препаратов витамина D при сердечно-сосудистых заболеваниях, сахарном диабете. Описано влияние витамина D на подавление кальцификации сосудов, ингибирование пролиферации гладкомышечных клеток сосудов, регуляцию уровня провоспалительных цитокинов и ренин-ангиотензин-альдостероновой системы. Выполненный нами анализ литературных данных свидетельствует о необходимости продолжения исследований с оценкой эффективности коррекции сниженного уровня витамина D в крови у пациентов с АГ, протекающей в сочетании с ожирением, дислипидемией.
A review of literature data on the effect of vitamin D on the condition of patients with arterial hypertension combined with obesity and dyslipidemia is presented. The potential mechanisms by which vitamin D can affect the vascular wall, endothelial function, cholesterol and low-density lipoprotein levels, glucose tolerance, insulin levels and sensitivity to it, the number of insulin receptors, and can participate in inflammatory processes, are described. The results of studies describing the effects of taking vitamin D drugs in cardiovascular diseases, diabetes mellitus are presented. The effect of vitamin D on the suppression of vascular calcification, inhibition of vascular smooth muscle cell proliferation, and regulation of the level of proinflammatory cytokines and the renin-angiotensin-aldosterone system is described. Our analysis of the literature data indicates the need to continue research to assess the effectiveness of correction of reduced levels of vitamin D in the blood of patients with hypertension, occurring in combination with obesity, dyslipidemia.
Clinical Management of Endogenous Hypercortisolism during the COVID-19 Pandemic
Authors: Радюк Д.В. , Данилова Л.И. , Журавлев В.А. , Романовский А.А. , Лущик М.Л. 
Published: March 2022

В статье рассматривается тактика ведения эндогенного гиперкортизолизма в условиях пандемии COVID-19. Указаны риски для пациентов во время высокой заболеваемости COVID-19 и методы их коррекции. Отдельное внимание уделено мерам, применяемым для снижения риска инфицирования пациентов с гиперкортизолизмом, их близких и медицинского персонала. Представлен алгоритм обследования пациентов и аспекты дифференциальной диагностики различных вариантов гиперкортизолизма. Подробно разобраны диагностические тесты и сформированы подходы к их корректной интерпретации. Проведен разбор методов диагностики с учетом высокой распространенности COVID-19. Суммированы критерии для пациентов, которые нуждаются в срочном обследовании и лечении. Дан анализ существующим методам лечения. Перечислены показания и основные подходы к хирургическому лечению различных вариантов гиперкортизолизма. Отдельное внимание уделено роли медикаментозной терапии в лечении гиперкортизолизма. Представлены схемы терапии, даны рекомендации по контролю в ходе лечения и дальнейшему наблюдению.
The article deals with clinical managing of endogenous hypercortisolism during the COVID-19 pandemic. Special attention is paid to the medical therapy in the treatment of hypercortisolism.The risks for patients during the high incidence of COVID-19 and methods of their correction are specified. Special attention is paid to the measures used for risk reduction of infection of patients with hypercortisolism, their relatives and medical personnel. The algorithm of examination of patients and aspects of differential diagnostics of various variants of hypercortisolism are presented. Diagnostic tests are analyzed in detail and approaches to their correct interpretation are formed. The analysis of diagnostic methods is carried out taking into account the high prevalence of COVID-19. The criteria for patients who need urgent examination and treatment are summarized. The analysis of existing treatment methods is given. Indications and main approaches to surgical treatment of various variants of hypercortisolism are listed. Special attention is paid to the role of medical therapyin the treatment of hypercortisolism. Treatment regimens are presented, recommendations are given for monitoring during treatment and further monitoring.