bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessing Long Non-coding RNAs in Tobacco-associated Oral Cancer
Authors: Sehgal Shelly , Mishra Manish Kumar , Gupta Sachin , Shivangi  
Published: June 2022

Abstract:
Cancer is one of the compelling and pegged diseases battled by clinicians and researchers
worldwide. Among different types of cancer, oral cancer holds the sixth position globally. With an
escalating prevalence in Asian countries, India, China, and Pakistan constitute a large proportion of
total incidents of oral cancer patients in terms of new cases or deaths. This mounting prevalence is
ascribed to poor oral hygiene and rampant use of substances earmarked as potential risk factors for
the disease. Risk factors (dietary/lifestyle habits/occupational/environmental) trigger the activation of
oncogenes, dysregulation of lncRNA and miRNA, and silence the tumor suppressor genes, which
robustly contributes to the onset and progression of tumorigenesis in oral squamous cell carcinoma.
Evidence suggests that specific carcinogens identified in tobacco and related products alter many
cellular pathways predisposing to advanced stages of oral cancer. Long non-coding RNAs represent a
broad group of heterogenous transcripts longer than 200 nucleotides which do not translate to form
functional proteins. They regulate various cellular pathways by specifically interacting with other
RNAs, DNA, and proteins. Their role in the pathogenesis of OSCC and other cancer is still being
debated. In this review, we discuss the molecular insights of significant lncRNAs involved in some
crucial deregulated pathways of tobacco-associated OSCC. The implications and challenges to
harnessing the potential of lncRNAs as biomarkers in early diagnosis and targeted treatment have also
been analyzed.
Recent Progress in Histone Deacetylase (HDAC) 1 Inhibitors as Anticancer
Agent
Authors: Patel Preeti , Wahan Simranpreet K. , Vishakha S. , Kurmi Balak Das , Gupta Ghanshyam Das , Rajak Harish , Asati Vivek 
Published: June 2022

Abstract:
Histone deacetylases (HDACs) are essential for maintaining homeostasis by catalyzing histone
deacetylation. Aberrant expression of HDACs is associated with various human diseases. Although
HDAC inhibitors are used as effective chemotherapeutic agents in clinical practice, their applications
remain limited due to associated side effects induced by weak isoform selectivity. HDAC1 displays
unique structure and cellular localization as well as diverse substrates and exhibits a wider range of biological
functions than other isoforms. HDAC1 displays a unique structure primarily found in the nucleus
and involved in epigenetic and transcriptional regulation. HDAC1 is ubiquitously expressed and associated
with Sin3, NuRD, and CoRest transcription repressive complexes responsible for distinct cellular
processes like cell proliferation and survival. HDAC1 inhibitors have been effectively used to treat
various cancers such as gastric, breast, colorectal, prostate, colon, lung, ovarian, pancreatic, and inflammation
without exerting significant toxic effects. In this review, we summarize four major structural
classes of HDAC1 inhibitors (i.e., hydroxamic acid derivatives, benzamides, hydrazides, and thiols)
with their structural activity relationship. This review is a comprehensive work on HDAC1 inhibitors to
achieve deep insight of knowledge about the structural information of HDAC1 inhibitors. It may provide
up-to-date direction for developing new selective HDAC1 inhibitors as anticancer agents.
Ethnomedical Applications and Conservation Status of Leguminosae- Caesalpinioideae Plants in Uttar Pradesh, India
Authors: Pandey Shivaraman , Singh Lav , Srivastava Ravi Prakash , Kushwaha Arun Kumar , Dixit Pooja , Saxena Gauri , Chaudhary Lal Babu 
Published: June 2022

Background:This review highlights the folklore, ethnomedicinal uses and conservation status of Caesalpinioideae in Uttar Pradesh (India).Aims:It aims at compiling available data on traditional medicine, biological activity, phytochemical information and assessing the regional red list status of Caesalpinioideae in Uttar Pradesh. The information provided would help in formulating new drugs and medicines and addressing global conservation issues of such medicinally exploited species.Methods:The current study included an extensive and systematic review of available literature, the study of previous collections of herbarium specimens, random interviews with locals and tribals, field surveys, and GeoCAT tool-based assessment during 2016-2020. The study reports that the majority of species of Caesalpinioideae are used for curing digestive problems (about 20 species) and skin diseases (19 species).Result:Almost all the species have antimicrobial and antioxidant properties. These pharmacological activities can be attributed to the presence of various types of anthraquinones in plants.Conclusion:The regional conservation status reveals that eight species qualified for the status of regionally threatened category while two species fall under the near threatened category.
Fabrication and Optimization of Electrospun Polymeric Nanofibers
Loaded with 5-Fluorouracil and Rosemary Extract
Authors: Jamali Reza , Ghassami Erfaneh , Dinani Masoud Sadeghi , Ghasemi Razieh , Mirian Mina 
Published: June 2022

Background:
Topical 5-fluorouracil (5FU) is one of the most prescribed medications
for different types of skin cancer; however, it is associated with drug resistance and adverse effects.
Rosemary extract has promising dose-dependent antitumor effects, as well as a synergistic
effect in combination with 5-fluorouracil, besides sensitization of the 5-FU-resistant cells.

Objective:
Polymeric nanofibers loaded with 5FU and rosemary extract were optimized to combine
both ingredients in one controlled release drug delivery system, aiming to enhance the efficacy
while retaining the adverse effects.

Method:
Polymeric nanofibers loaded with 5-FU and rosemary were fabricated via electrospinning
technique. Design expert software was utilized to study the effect of independent variables,
including polymer concentration, voltage, and feeding rate on the characteristics of the resulting
nanofibers. Afterwards, the FTIR spectrum and release kinetic of the drug and extract from the
optimized nanofibers and their cytotoxic effect against A375 cell line were investigated.

Results:
The formulation composed of 6.65% PVA electrospun at 1 mL.h-1 and 17.5kV was chosen
as the optimum fabrication condition. The mean diameter of the optimized nanofibers was 755
nm. The drug and rosemary extract contents were 75.38 and 93.42%, respectively. The fabrication
yield was 100%, bioadhesion force was 1.28 N, and bead abundance was 10 per field. The cytotoxicity
of the optimized formulation was significantly higher than the control groups.

Conclusion:
According to the appropriate loading percentage, release efficiency and release kinetics,
bioadhesion force, and cytotoxicity, these nanofibers could be further investigated as a topical
treatment option to increase the efficacy of 5-FU.
Ecological Burden of e-Waste in Bangladesh—an Assessment to Measure the Exposure to e-Waste and Associated Health Outcomes: Protocol for a Cross-sectional Study
Authors: Parvez Sarker Masud , Hasan Shaikh Sharif , Knibbs Luke D , Jahan Farjana , Rahman Mahbubur , Raqib Rubhana , Islam Nafisa , Aich Nirupam , Moniruzzaman Mohammad , Islam Zahir , Fujimura Masatake , Sly Peter D 
Published: June 2022

Background
e-Waste is a rapidly growing waste stream worldwide, and Bangladesh is a hub of e-waste handling. Informal e-waste recycling operations involve crude methods for dismantling, repairing, sorting, and recycling electronic goods with bare hands and without personal health protections. Direct inhalation or dermal exposure to toxicants during informal recycling is common. Evidence suggests that e-waste–derived toxicants pollute the terrestrial ecosystem and have been linked with adverse health effects. However, e-waste recycling–related occupational health hazards have not been adequately explored in the context of Bangladesh.

Objective
Our study aims to expand the current understanding of exposure to e-waste. This study will measure the metal concentrations in biological and environmental samples and evaluate the relationship between heavy metals and the biochemical systems of the e-waste workers.

Methods
The study uses a cross-sectional study design consisting of an exposed site and a nonexposed control site. The trained team collected information on individual exposures, detailed work and medical history, and biological samples (blood, urine, and hair) from each subject. This study will measure heavy metal levels (lead, cadmium, and mercury) and biochemical parameters (hematological, hormonal, renal, and others) from the biological samples with reported physical function as outcomes of interest. In addition, we also collected soil and dust samples from both exposed and nonexposed control sites to measure the health risk. All the environmental samples will be analyzed using inductively coupled plasma mass spectrometer to determine metal concentrations. We will also conduct a qualitative investigation for a deeper understanding of the e-waste management system in Bangladesh.

Results
The protocol has been approved by the Institutional Review Boards of the International Centre for Diarrheal Disease Research, Bangladesh, and The University of Queensland’s Human Behavioral Ethics Committee. Informed written consent was obtained from all participants. We recruited 199 workers from the e-waste sites with at least 5 years of exposure and 104 control subjects with no industrial or e-waste exposure. Sample analysis is estimated to be completed in 2022.

Conclusions
Although many studies have identified potential adverse health outcomes from exposure to e-waste, there is a lack of published epidemiological research in Bangladesh. Research in this field is particularly pressing in the context of the current e-waste trend and the need to deepen the understanding of exposures and outcomes.

International Registered Report Identifier (IRRID)
DERR1-10.2196/38201
Total postprandial hepatic non-esterified and dietary fatty acid uptake is increased and insufficiently curbed by adipose tissue fatty acid trapping in prediabetes with overweight
Authors: Ye Run Zhou , Montastier Émilie , Noll Christophe , Frisch Frédérique , Fortin Mélanie , Bouffard Lucie , Phoenix Serge , Guérin Brigitte , Turcotte Éric E. , Carpentier André C. 
Published: June 2022

<p>Excessive lean tissue uptake of fatty acids (FA) is important in the development of insulin resistance and may be caused by impaired dietary FA (DFA) storage and/or increased non-esterified FA (NEFA) flux from adipose tissue intracellular lipolysis. Cardiac and hepatic total postprandial FA uptake of NEFA+DFA has, however, never been reported in prediabetes with overweight. Twenty individuals with impaired glucose tolerance (IGT) and 19 participants with normal glucose tolerance (NGT) and normal fasting glucose underwent postprandial studies with whole-body positron emission tomography/computed tomography (PET/CT) with oral [18F]-fluoro-thia-heptadecanoic acid and dynamic PET/CT with intravenous [11C]-palmitate. Hepatic (97[range 36-215]mmol/6h <em>vs</em>. 68[23-132]mmol/6h, P=0.03), but not cardiac (11[range 4-24]mmol/6h <em>vs</em>. 8[3-20]mmol/6h, P=0.09) uptake of most sources of postprandial FA (NEFA+DFA uptake) integrated over 6 hours was higher in IGT <em>vs.</em> NGT. DFA accounted for lower fractions of total cardiac (21[5-47]% <em>vs</em>. 25[9-39]%, P=0.08) and hepatic (19[6-52]% <em>vs</em>. 28[14-50]%, P=0.04) uptake in IGT <em>vs</em>. NGT. Increased adipose tissue DFA trapping predicted lower hepatic DFA uptake, and was associated with higher total cardiac fatty acid uptake. Hence, enhanced adipose tissue DFA trapping in the face of increased postprandial NEFA flux is insufficient to fully curb increased postprandial lean organ FA uptake in prediabetes with overweight (ClinicalTrials.gov; NCT02808182). </p>
PENERAPAN PRINSIP UTI POSSIDETIS JURIS DALAM PENETAPAN BATAS DARAT INDONESIA DAN TIMOR LESTE
Authors: Melkianus Paulus Ekon Yanto 
Published: June 2022

Abstrak
Indonesia dan Timor Leste menetapkan batas darat dalam Provisional Agreement on the Land Boundary, 2005 berdasarkan prinsip uti possidetis juris, yang dimaknai batas negara baru harus mengikuti batas wilayah dari negara yang pernah mendudukinya dan tidak dapat dikesampingkan oleh prinsip hak menentukan nasib sendiri. Namun, batas darat yang ditetapkan dalam Persetujuan Sementara itu, tidak dapat memuat batas darat secara definitif sebab masih terdapat 4 (empat) segmen batas yang tidak dapat disepakati, yakni segmen Noelbesi-Citrana, Manusasi-Subina dan Mota Malibaka. Penelitian ini bertujuan untuk menganalisis alasan-alasan kegagalan Indonesia dan Timor Leste menyelesaikan batas darat dan menjelaskan prinsip hukum yang tepat diterapkan dalam penetapan batas di 4 (empat) segment tersebut. Jenis penelitian yang digunakan dalam penulisan artikel ini adalah penelitian normatif. Hasil penelitian dapat dibuktikan bahwa Indonesia-Timor Leste gagal menetapkan batas darat di 4 (empat) segmen batas itu karena kelemahan dari prinsip uti possidetis juris yang mewajibkan negara baru untuk mengikuti batas yang ditetapkan oleh negara kolonial terdahulu. Oleh karena itu, prinsip hukum yang tepat untuk diterapkan adalah prinsip uti possidetis juris yang dimaknai kembali mencakup batas kerajaan terdahulu yang diakui dan terpelihara oleh masyarakat adat secara turun temurun.
Kata Kunci: perbatasan negara bagian; perjanjian batas negara bagian; uti possidetis juris

Abstract
Indonesia and Timor Leste set land boundaries in the Provisional Agreement on the Land Boundary 2005 based on the principle of uti possidetis juris, which means that new state boundaries must follow the territorial borders of the country that was once occupy it and cannot be overridden by the principle of self-determination.However, the land boundaries defined in the Provisional Agreement cannot contain land boundaries definitively because there are still 4 (four) boundary segments that cannot be agreed upon, namely the Noelbesi-Citrana, Manusasi-Subina and Mota Malibaka segments.This study aims to analyze the reasons for the failure of Indonesia and Timor Leste to resolve land boundaries and explain the appropriate principles applied in the determination of boundaries in the 4 (four) segments. This type of research used in writing this article is normative research.The results of this study can be proven that Indonesia-Timor Leste failed to establish land boundaries in the 4 (four) boundary segments because of the weakness of the uti possidetis juris principle which obliged the new country to follow the boundaries set by the previous colonial state.Therefore, the right legal principle to apply is the principle of uti possidetis juris which is re-interpreted to include the boundaries of the previous kingdom which were recognized and maintained by indigenous peoples from generation to generation.
Keywords: states borders; states boundary agreements; uti possidetis juris
PENGHIDUPAN KEMBALI BADAN HUKUM PENDIDIKAN TINGGI PASCA PUTUSAN MK NOMOR 11-14-21-126-136/PUU-VII/2009
Authors: Akbar Nursasmita Muhammad 
Published: June 2022

ABSTRAK
Pendidikan tinggi mengalami berbagai dinamika perkembangan, salah satunya pengelolaan perguruan tinggi dengan sistem badan hukum. Dalam sejarahnya konsep badan hukum pendidikan telah dibatalkan oleh Mahkamah Konstitusi. Pada tahun 2012, DPR bersama Pemerintah membahas dan mengesahkan UU Perguruan Tinggi (UU PT), dimana dalam UU PT tersebut mencantumkan kembali klausul badan hukum dengan berbagai atribut otonomi yang dimilikinya. Hal tersebut menimbulkan polemik pada masyarakat. Dalam artikel ini penulis menjelaskan bagaimana proses pembatalan UU BHP oleh Mahkamah Konstitusi dilanjutkan proses pembahasan UU PT sehingga konsep badan hukum kembali dimasukkan di dalam UU PT, hingga pada akhirnya penulis membahas mengenai relasi antara MK dan DPR khususnya dalam hal pelaksanaan putusan MK di dalam proses pembuatan Undang-Undang. Metode penelitian yang dipilih adalah yuridis normatif, dengan pendekatan perundang-undangan, konseptual dan sejarah. Kesimpulan yang dapat diambil bahwa relasi antara MK dan DPR memiliki dinamika yang sangat bergantung pada kemauan para aktor politik serta dapat menggambarkan berjalannya sistem check and balances dalam kehidupan bernegara.
Kata kunci: badan hukum pendidikan; mahkamah konstitusi; pendidikan tinggi.

ABSTRACT
Higher education experiences various developmental dynamics, one of which is the management of higher education institutions with a legal entity system. Historically, the concept of an educational legal entity has been canceled by the Constitutional Court. In 2012, the DPR and Government discussed and ratified the PT Act, which PT Act re-included clauses of legal entities with various attributes of autonomy. This has led to a polemic in society. In this article, the writer explains how the process of cancellation of the BHP Act by the Constitutional Court, then discussion process of PT Act until the concept of legal entities is re-included in PT Act, finally author discusses the relationship between Constitutional Court and DPR, especially in terms of implementing the Constitutional Court's decision in law making process. The research method chosen was normative juridical, with a statutate, conceptual and historical approach. The conclusion that can be drawn is that the relationship between Constitutional Court and DPR was dynamic which is highly dependent on the will of political actors and can describe the operation of the system of checks and balances in state life.
Keywords: constitutional court; educational legal entities; higher education.
KONSEKUENSI HUKUM LOGO YANG DIDAFTARKAN SEBAGAI CIPTAAN DAN MEREK SEBELUM BERLAKUNYA UNDANG-UNDANG NOMOR 28 TAHUN 2014 TENTANG HAK CIPTA
Authors: Havinando Adi Arief 
Published: June 2022

ABSTRAKLogo saat ini bukan hanya sebagai identitas semata, tapi lebih dari itu peran dari logo telah menjadi suatu urgensi untuk mempresentasikan makna terkait suatu daerah, sosial, ekonomi, dan sebagainya sehingga logo perlu didaftarkan sebagai sebuah karya intelektual. Sebelum berlakunya UU Nomor 28 Tahun 2014 tentang Hak Cipta, logo sebagai sebuah karya intelektual masih dapat dicatat sebagai sebuah ciptaan dan merek. Namun, ketika berlakunya UU Nomor 28 Tahun 2014 tentang Hak Cipta, logo tidak lagi dapat dimohonkan untuk dicatat sebagai sebuah ciptaan. Dengan menggunakan penelitian yuridis normatif dan pendekatan perundang-undangan dan konseptual, penelitian ini dimaksudkan untuk menganalisis penerapan hukum positif yang ada dengan praktek yang terjadi di masyarakat. Berdasarkan kajian analisis menunjukkan hasil bahwa kasus tumpang tindih terhadap suatu karya intelektual yang didaftarkan sebagai ciptaan dan merek menjadi salah satu konsekuensi hukum seperti konsekuensi itikat tidak baik dari pihak yang memungkinkan memanfaatkan karya intelektual berupa logo untuk didaftarkan secara pribadi tanpa hak sehingga dapat ditiru dan dimodifikasi sebagai klaim dari kepemilikian pihak lain. Selain itu, konsekuensi hukum lainnya memicu timbulnya kegiatan passing off. Kata kunci: hak cipta; konsekuensi hukum; logo.
ABSTRACTLogo is not only an identity, more than that the logo has become an urgency to present meanings related to an area, social, economic, and so on, so the logo needs to be registered as an intellectual property rights. Before the enactment of Law number 28 of 2014 about Copyright, a logo as intellectual property works can still be recorded as a copyright and a trademark. However, when Law number 28 of 2014 about Copyright estabilished, after that a logo can no longer requested to be recorded as a copyright. By using normative juridical research and statutory and conceptual approaches, this study is intended to analyze the application of existing positive law with practices that occur in society. Based on the analysis, the results show that an overlapping case of a copyright law that is registered as a copyright and a trademark is one of the legal consequences such as a bad faith consequence from the party that allows the use of intellectual works in the form of logos to be registered privately without rights so that they can be copied and modified as claims from ownership of other parties. In addition, other legal consequences trigger passing off activities. Keywords: copyright; legal consequence; logo.
REFORMASI AGRARIA DALAM KERANGKA OTONOMI DAERAH
Authors: Fauzi Ahmad 
Published: June 2022

ABSTRACT
Penelitian ini membahas bagaimana pembaruan agraria dipercayai sebagai proses perombakan agraria di daerah dan pembangunan kembali struktur sosial masyarakat, serta terjaminnya kepastian penguasaan atas tanah bagi rakyat sebagai sumberdaya kehidupan mereka, sistem kesejahteraan sosial dan jaminan sosial bagi rakyat di daerah. Metode penelitian yang digunakan yuridis normatif, hanya meneliti normanya saja sehingga hanya meneliti bahan kepustakaan. Penelitian ini menggunakan spefikasi penelitian yang bersifat deskriptif analitis yaitu penelitian yang menggambarkan secara menyeluruh dan sistematis dari pokok masalah. Hasil yang diperoleh diharapkan memberikan gambaran yang sebenarnya dari permasalahan, maka daerah diharapkan mampu meningkatkan daya saing dengan memperhatikan prinsip demokrasi, pemerataan, keadilan, keistimewaan, dan kekhususan serta potensi dan keanekaragaman daerah dalam sistem Negara Kesatuan Republik Indonesia. Urusan pelayanan pertanahan secraa yuridis formal adalah merupakan urusan wajib yang diberikan oleh Undang-undang kepada pemerintahan daerah, untuk tercapainya kepastian dan perlindungan hukum serta keadilan dan kemakmuran bagi seluruh rakyat Indonesia pemerintah mengeluarkan Peraturan Presiden Nomor 86 Tahun 2018 tentang Reforma Agraria. Keywords: agraria; otonomi daerah; reformasi.
ABSTRACT
This study discusses how agrarian reform is believed to be a process of overhauling land in the region and rebuilding the social structure of society, as well as ensuring certainty over land tenure for the people as their source of livelihood, social welfare system and social security for the people in the region. The research used is normative juridical, only researching the norms so that only researching library materials. In this study, the author uses research specifications that are descriptive analytical, namely research that describes thoroughly and systematically from the subject matter. From the results obtained, it is expected to provide a true picture of the problem. So the regions are expected to be able to increase competitiveness by taking into account the principles of democracy, equity, justice, privilege, and specificity as well as the potential and diversity of regions in the system of the Unitary State of the Republic of Indonesia. The affairs of land services are mandatory matters given by law to regional governments. To achieve legal certainty and protection as well as justice and prosperity for all Indonesian people, the government issued Presidential Regulation Number 86 of 2018 concerning Agrarian Reform. Keywords: agrarian; reform; regional autonomy.