bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Effects of a Compensatory Training Program Adding an Isoinertial Device in the Shoulder Function on Young Tennis Players
Authors: Fernandez-Fernandez Jaime , Moreno-Perez Victor , Cools Ann , Nakamura Fábio Yuzo , Teixeira Anderson Santiago , Ellenbecker Todd , Johansson Fredrik , Sanz-Rivas David 
Published: November 2022

Abstract
Fernandez-Fernandez, J, Moreno-Perez, V, Cools, A, Nakamura, FY, Teixeira, AS, Ellenbecker, T, Johansson, F, and Sanz-Rivas, D. The effects of a compensatory training program adding an isoinertial device in the shoulder function on young tennis players. J Strength Cond Res 37(5): 1096–1103, 2023—The aim of this study was to analyze whether a compensatory training program, including isoinertial flywheel training, could reduce shoulder imbalances in a group of asymptomatic young tennis players. After an initial evaluation, 26 young tennis players were assigned to either a supervised flywheel training group (FTG, n = 13) or a control group (CG, n = 13). Shoulder passive internal (IR) and external rotation (ER) range of motion (ROM) as well as shoulder IR and ER maximal isometric strength were measured before and after a 12-week training intervention, performed 3 times per week. After the intervention, results showed significant changes for IR (p < 0.001, effect size [ES] = 1.83) and ER (p < 0.001, ES = 1.77) on the dominant (D) side, and IR on the nondominant (ND) side (p < 0.001, ES = 2.24) in the FTG compared with the CG. Regarding the ROM values, results showed that the FTG achieved significantly greater increases for the IR ROM (p < 0.001, ES = 3.32) and total ROM (TROM) (p = 0.004, ES = 1.39) on the D and ND sides (IR ROM: p = 0.002, ES = 1.53; TROM: p < 0.001, ES = 2.35) than the CG. Moreover, the CG displayed larger decrements in ER ROM (p = 0.016, ES = 1.12) on the ND side after the training period than the FTG. The conducted compensatory training program was effective to increase the ER strength and IR mobility of the FTG players, which led to a reduction in the glenohumeral imbalances.
Assessing the Attainment Rates of Updated CDC Milestones Using a New Israeli Developmental Scale
Authors: Sadaka Yair , Sudry Tamar , Zimmerman Deena R. , Avgil Tsadok Meytal , Baruch Ravit , Yardeni Hadar , Ben Moshe Dror , Akiva Pinchas , Amit Guy 
Published: November 2022

OBJECTIVES
Developmental milestones norms are widely used worldwide and are fundamental for early childhood developmental surveillance. We compared a new Israeli evidence-based national developmental scale with the recently updated Centers for Disease Control and Prevention (CDC) checklists.

METHODS
We used a cohort of nearly 4.5 million developmental assessments of 758 300 full-term born children aged 0 to 6 years (ALL-FT cohort), who visited maternal child health clinics in Israel for routine developmental surveillance. Among the assessed milestones of 4 developmental domains (gross motor, fine motor, language, and personal–social) we identified milestones that had equivalents on the CDC checklists and assessed the attainment rates of the Israeli children at the ages recommended by the CDC, at which ≥75% of the children would be expected to achieve the milestone. The analysis was repeated on a subgroup of 658 958 children who were considered healthy, typically developing by their birth and growth characteristics (NORMAL-FT cohort).

RESULTS
There were 29 milestones, across all developmental domains and assessment ages, whose definitions by both tools were compatible, and could be compared. The attainment rate at the CDC-recommended age was &gt;90% for 22 (76%) and 23 (79%) milestones, and the median attainment rates were 95.2% and 96.3% in the ALL-FT and NORMAL-FT cohorts, respectively.

CONCLUSIONS
For almost all comparable milestones of all domains and all ages, children of the Israeli cohorts achieved the milestones earlier than expected by the CDC-defined threshold age. Evidence-based analysis of milestone norms among different populations may enable adjustments of developmental scales and facilitate more personalized developmental surveillance.
Encuesta: Nivel de conocimiento de la población urbana sobre los alimentos agroecológicos
Authors: Vivas-Vivas Ramiro José , Pazmiño-Mayorga Jaime Alberto , Caicedo-Chávez Jorge David , Cepeda-Bastidas Darío Alexander , Corro-Alarcón Ivanna Katherine 
Published: November 2022

Introducción. El consumo de alimentos afecta el ambiente, por lo que es necesario investigar qué nivel de conocimiento tiene la población urbana sobre la procedencia de los alimentos que consumen. Objetivo. Diseñar, validar y determinar la confiabilidad de un instrumento para evaluar el nivel de conocimiento que tiene la población urbana respecto a los alimentos agroecológicos. Materiales y métodos. El trabajo se desarrolló en la Universidad Central del Ecuador en Quito, Ecuador, en el periodo 2020-2021. El tipo de investigación fue exploratorio-descriptivo, con un diseño no experimental y un muestreo no probabilístico estratificado. El contenido del instrumento se evaluó con el método delphi con la participación de diecisiete expertos. Se aplicaron dos pruebas piloto a 370 y 1323 participantes. La consistencia interna y el índice de homogeneidad se determinó mediante el alpha de Cronbach. La dimensionalidad del constructo se estableció con la curva de Cronbach-Mesbah. La validez del constructo se evaluó con un análisis factorial. Resultados. La validez del contenido arrojó un valor mayor al 75 % de convergencia entre expertos. En la validación de la consistencia interna el Alpha de Cronbach fue de 0,9 y el índice de homogeneidad fue mayor de 0,2. En el estudio de la dimensionalidad del constructo la curva de Cronbach-Mesbah, indicó que la unidimensionalidad se cumplió en todo el instrumento. En la validez del constructo en el análisis factorial, se observó que la medida Kaiser-Meyer-Olkin fue de 0,753. La esfericidad de Bartlett fue de 0,000 y la prueba de extracción de los factores fue mayor al 77 %. Conclusiones. El instrumento logró una validez y confiabilidad alta tanto en su contenido valorado por expertos, como en su consistencia interna, dimensionalidad y validez del constructo realizado por métodos estadísticos. El instrumento es confiable y puede ser aplicado en la población urbana.
A survey of changes in taste and food preferences related to the coronavirus disease (COVID-19) in Hungary
Authors: Sugár M. , Fusz K. , Pusztai D. , Rozmann N. , Macharia J.M. , Pintér M. , Raposa B. 
Published: November 2022

AbstractA plethora of research and empiric observation supported the claim that–among other symptoms–diseases often affect the ability to smell and the sense of taste, possibly affecting the taste- and food preferences as well.The aim of the present study was to shed light on the impact of COVID-related smell- (dysosmia/anosmia) and taste function-disorder/loss (dysgeusia/ageusia) on the food and taste preferences COVID-19 patients of different symptomatic and pre-existing conditions and demographic backgrounds.The research based on a descriptive, cross-sectional survey. In total, 514 participants filled our self-administered online questionnaire. Thirteen participants were excluded according to the exclusion criteria. Descriptive statistics, Chi-square test, t-test for correlation coefficient, were performed.The most common long COVID symptom was fatigue/weakness (53.1%) followed by anosmia (50.9%) and tachycardia (33.5%). Many participants reported dysgeusia/ageusia during the acute phase of the disease, which sometimes prevailed as a long COVID symptom. A high percentage of participants reported that they rejected all kinds of meat of animal origin except cold cuts for their duration of recuperation, which proved to be the most common dietary change during the post-COVID period so far.
Splenogonadalis fúzió egy csecsemőben
Authors: Rónaky Rebeka , Buzogány Mária , Farkas András 
Published: November 2022

Összefoglaló. A splenogonadalis fúzió ritka fejlődési
rendellenesség, melynek lényege az ivarmirigy (leggyakrabban a here) és a
lépszövet rendellenes kapcsolódása. A szerzők egy féléves csecsemő esetét
kívánják bemutatni, akinél már a megszületést követően észlelhető volt a bal
oldali here megnagyobbodása. A műtét előtti képalkotó vizsgálatok (ultrahang,
MRI), a fizikális vizsgálat és az intraoperatív lelet a splenogonadalis fúzió
lehetőségét vetette fel. A műtét során a makroszkóposan lépszövetnek imponáló
elváltozás eltávolításra került, majd rutinorchiopexia történt. A hisztológiai
vizsgálat alátámasztotta a feltételezett diagnózist. Az entitást 1883-ban írták
le először, azóta kevesebb mint 200 esetről számoltak be az angol nyelvű
irodalomban. Az utóbbi 30 évben magyar szerzőktől egy közlemény jelent meg. Az
elváltozás a banális szülési trauma okozta haematomára, újszülöttkori
heretorzióra, malignus heretumorra is hasonlíthat, komoly
differenciáldiagnosztikai problémát okozva. A splenogonadalis fúzió jóindulatú
elváltozás, a helyes diagnózis esetén elkerülhető a felesleges orchiectomia. Orv
Hetil. 2022; 163(7): 288–290.
Summary. Splenogonadal fusion is a rare congenital malformation
specified as the presence of splenic tissue connected to the gonads (mainly
testis). The authors present the case of a 6-month-old male infant, in whom left
inguino-scrotal mass was noticed soon after birth. The mass, based on
preoperative diagnostic setup (ultrasound, MRI), physical examination and
intraoperative findings were suspicious for splenogonadal fusion. At surgery,
the mass was resected from the testis, which macroscopically resembled a splenic
tissue. Following the resection, orchiopexy was performed. Histology confirmed
splenogonadal fusion. Since the first description of the malformation in 1883,
only less than 200 cases have been reported in the English literature. Only a
single article has been published in Hungary in the last 30 years. Splenogonadal
fusion represents a serious differential diagnostic problem. Hematoma caused by
trauma, neonatal testicular torsion, benign or malignant testicular tumors may
also present similarly. In our case, proper presumptive diagnosis made it
possible to avoid unnecessary orchiectomy. Orv Hetil. 2022; 163(7): 288–290.
Szemészeti érintettséggel járó paraneoplasiás pemphigoid
Authors: Fodor Eszter , Silló Pálma , Lukács Andrea , Kárpáti Sarolta , Nagy Zoltán Zsolt , Füst Ágnes 
Published: November 2022

Összefoglaló. A nyálkahártya-pemphigoid különleges formája a
paraneoplasiás pemphigoid, amely primer malignus betegséghez társul; lefolyása
szokatlanul gyors, és a klasszikus immunszuppresszív terápiákkal szemben
rezisztens lehet. Közleményünkben három eseten keresztül mutatjuk be a
paraneoplasiás pemphigoid megjelenését, diagnosztikáját és a terápiás
kihívásokat. A diagnózist a kórelőzményi adatok és az immunfluoreszcens
vizsgálatok segítik. A terápiás célkitűzés a progresszió lassítása
immunszuppresszív kezeléssel, amely a zajló onkológiai kezelés mellett
kontraindikált lehet. Tekintettel arra, hogy jelenleg nincs konszenzus ennek a
ritka kórképnek a diagnosztikájában és kezelésében, különösen fontos, hogy a
társszakmák (szemészet, bőrgyógyászat, fogászat, fül-orr-gégészet, onkológia,
immunológia) együttműködésével a betegség minél hamarabb felismerhető legyen, és
a kezelést ezáltal minél korábban el lehessen kezdeni. Orv Hetil. 2022; 163(18):
720–725.
Summary. Paraneoplastic mucous membrane pemphigoid, a rare
pemphigoid variant is associated with primary malignancy, and characterised by
fulminant progression and frequent ineffectivity of classical systemic
immunosuppression. In this paper, the clinical features, diagnostic and
therapeutical challenges are presented through three cases. Detailed history and
analysis of the immunofluorescent samples help the diagnosis. The therapeutic
goal is to prevent the progression with systemic immunosuppressive treatment,
which can be contraindicated during the ongoing oncological therapy. In absence
of consent in the exact diagnostic criteria and management protocol of this rare
condition, consultation with other specialists (ophthalmologist, dermatologist,
dentist, ear-nose-throat specialist, immunologist) has high importance in early
diagnosis and treatment. Orv Hetil. 2022; 163(18): 720–725.
A természetes ölősejtek szerepe az anyai-magzati immunhomeostasis fenntartásában
Authors: Lakatos Kornél , Elias Kevin M. , Berkowitz Ross S. , Hasselblatt Kathleen , Végh György , Fülöp Vilmos 
Published: November 2022

Összefoglaló. A sikeres fogantatás, beágyazódás és terhesség komplex
és szervezett kommunikációt igényel az embrió (allograft) és az anya (gazda)
immunrendszere között. A különböző leukocyta-alcsoportok fontos szerepet
játszanak az immunválasz szervezésében a magzati–anyai határfelületen. Vannak
bizonyos hasonlóságok a tumorsejteknek az immunrendszert kijátszó kóros és az
embrionális eredetű trophoblastsejteknek az anyai deciduába irányuló fiziológiás
inváziója között. A decidualis vagy uterinalis természetes ölősejtek a
természetes ölősejtek speciális részhalmaza, és a macrophagokkal és a
dendritikus sejtekkel együtt a veleszületett immunrendszer részét képezik, ezért
ők az első immunsejtek, amelyek kapcsolatba lépnek bármely behatolóval, legyen
az daganat vagy embrionális szövet. Érdekes módon a decidualis természetes
ölősejtek nemcsak nem támadják meg az invazív trophoblastsejteket, hanem
kifejezetten elősegítik azok progresszióját. Angiogenikus aktivitásuk
megkönnyíti és koordinálja a kialakuló méhlepény helyi vascularis átalakulását.
Dolgozatunkban áttekintjük a trophoblastsejtek és a decidualis természetes
ölősejtek kölcsönhatásait, a decidualis természetes ölősejtek szerepét a decidua
vascularisatiójában és immunháztartásában. Orv Hetil. 2022; 163(19):
734–742.
Summary. Successful conception, implantation and pregnancy require a
complex and organized communication between the embryonal (allograft) and the
maternal (host) immune system. Different leukocyte subsets have an important
role in orchestrating the immune response at the fetal-maternal interface. There
are certain similarities between the immune invasion of tumor cells and the
physiological invasion of the trophoblastic cells of embryonic origin into the
maternal decidua. The decidual natural killer cells are a special subset of
natural killer cells and alongside with macrophages and dendritic cells, they
are part of the innate immune system therefore they are the first immune cells
contacting any intruder whether it is a tumor or embryonic tissue. Interestingly
decidual natural killer cells not only do not eliminate invasive trophoblastic
cells, but specifically promote their progression. Their angiogenic activity
facilitates and coordinates local vascular remodeling of the forming placenta.
In this article we review the different nature of trophoblastic cell and
decidual natural killer cell interaction, the role of decidual natural killer
cells in the vascularization and immune homeostasis of the decidua. Orv Hetil.
2022; 163(19): 734–742.
Physio-chemical properties of methyl red-degrading strains isolated from textile wastewater
Authors: Luong Thi Thu Huong , Dang Thi Mai Anh , Nguyen Minh Thu , Nguyen Sy Nguyen , Ho Thi Loan , Ho-Tu Cuong 
Published: November 2022

Methyl red (MR)-reducing strains isolated from textile wastewater were identified and tested for physio-chemical properties. The bacterial colonies picked from the mineral medium supplemented with textile wastewater were transferred onto the mineral medium containing MR for the test. Two strains, namely SYK and STXL2, demonstrating the ability of MR decolorization in the agar medium were selected and purified. The strains SYK and STXL2 incubated in the liquid mineral medium with MR were able to reduce 100 % and 95.5 % of MR after 4 days incubation, respectively. Gram staining of both strains confirmed these two isolates were gram positive. The SYK strain has white, irregular and dry colonies while the STXL2 strain has orange, opaque, circular and glossy colonies. Both strains have short rod shape of cell under SEM images. The two strains were able to grow in the media such as Luria-Bertani medium, Meat-peptone broth, and Nutrient broth. The strain SYK were able to grow quickly in the medium with maltose while the strain STXL2 used glucose as the best carbon source. Biochemical tests showed that both strains had positive reaction in Voges-Proskauer test and negative reactions in lipase, cellulose, amylase, citrate, and gelatin hydrolysis tests. The SYK strain had positive reactions in protease, urease, and ammonia tests while the STXL2 strain had positive reaction in nitrate reduction test. The sequences of 16S rNA genes identified the SYK and STXL2 strains as Streptomyces cellulosae (100 % of similarity) and Rhodococcus ruber (99 % of similarity), and registered in the GenBank via the accessing number MZ414193 and MZ414194, respectively.
KARAKTERISASI RADIOACTIVE FISSION WASTE (RFW) DARI PRODUKSI RADIOISOTOP LUTESIUM-177 MENGGUNAKAN PROGRAM ORIGEN2
Authors: Rosmayani Lena , Rohanda Anis , Abdullatif R Farzand 
Published: November 2022

KARAKTERISASI RADIOACTIVE FISSION WASTE (RFW) DARI PRODUKSI RADIOISOTOP LUTESIUM-177 MENGGUNAKAN PROGRAM ORIGEN2. Jenis maupun jumlah limbah radioaktif hasil produksi nuklir terus meningkat seiring dengan berkembangnya pemanfaatan teknologi nuklir sehingga diperlukan pengelolaan yang baik agar tidak membahayakan masyarakat atau lingkungan. Produksi radioisotop untuk kedokteran nuklir menjadi salah satu sumber limbah radioaktif yang dihasilkan reaktor nuklir. Beberapa radiosotop yang diproduksi di teras Reaktor Serba Guna G.A Siwabessy (RSG–GAS) di antaranya Molibdenum-99, Iodium-125, Iridium-192 dan Lutesium-177 (177Lu). Penelitian ini bertujuan untuk mengetahui karakterisasi limbah produksi 177Lu yang dilakukan dengan menggunakan program komputer ORIGEN2 untuk mendapatkan sifat-sifat limbah RFW sehingga diperoleh teknik pengolahan limbah yang sesuai. Pada penelitian ini dilakukan karakterisasi limbah radioaktif pada produksi radioisotop 177Lu dari Target Lu2O3 pada berbagai posisi CIP pada daya 15 MWt dan 30 MWt dengan lama waktu iradiasi pada masing-masing tingkat daya selama 8 dan 12 hari. Dalam produksi radioisotop, target diiradiasi di fasilitas iradiasi teras RSG-GAS, target ditempatkan dalam ampul kuarsa yang kemudian ditempatkan di kapsul dalam (inner capsule) aluminium. Kemudian inner capsule aluminium tersebut dimasukkan ke dalam kapsul luar dan ditempatkan ke posisi iradiasi. Pasca Iradiasi target didinginkan dan selanjutnya dilakukan pengambilan radioisotop 177Lu. Pengambilan sampel radioisotop pasca iradiasi membentuk beberapa jenis limbah. Salah satunya adalah limbah fisi radioaktif (RFW) sebagai produk sampingan dengan sifat yang berbeda-beda. Selain dari target, limbah radioaktof juga dapat dihasilkan dari kapsul target. Iradiasi target membuat kapsul target yang terbuat dari kuarsa dan aluminium juga teraktivasi dan menjadi radioaktif. Maka dari itu dilakukan perhitungan konsentrasi aktivitas limbah hasil produksi radioisotop 177Lu. Hasil karakterisasi limbah RFW menggunakan program komputer ORIGEN2 dengan variasi fluks di berbagai posisi CIP pada daya 15 MWt maupun 30 MWt dengan lama iradiasi 8 maupun 12 hari diperoleh total konsentrasi aktivitas limbah dari produksi radioisotop 177Lu memiliki konsentrasi aktivitas diantara 1,06x1016 – 1,24x1016 Bq/g. Oleh karena itu, Limbah radioaktif RFW hasil produksi 177Lu diklasifikasikan dalam limbah radioaktif tingkat sedang berdasarkan Peraturan Pemerintah mengenai pengelolaan limbah radioaktif dan diperlukan pengelolaan yang teliti guna menjamin keselamatan.Kata kunci: RFW, Radioisotop, Lutesium-177, ORIGEN.
Молекулярный профиль нейроэндокринных опухолей
Authors: Исянгулова А. З. , Гордиев М. Г. 
Published: November 2022

Рост заболеваемости нейроэндокринными опухолями увеличивает интерес к изучению генетического ландшафта новообразований. В большей степени нейроэндокринные опухоли (НЭО) исследованы в контексте наследственных генетических синдромов, включая гены, такие как MEN1, VHL, TSC1 / TSC2, NF1 и CDKN1B. Взаимосвязь между наследственными (генеративными) мутациями в генах системы репараций ДНК и нейроэндокринными опухолями на сегодня практически не изучена.В условиях ГАУЗ «Республиканский клинический онкологический диспансер Министерства здравоохранения Республики Татарстан имени профессора М. З. Сигала» был изучен молекулярный профиль пациентов с диагнозом «нейроэндокринная опухоль» в зависимости от наследственного анамнеза. В проведенном исследовании у каждого четвертого пациента обнаруживались патогенные мутации. У 33 % пациентов при наличии наследственного анамнеза выявлены патогенные, либо условно-патогенные мутации
Clinical significance of club cell protein CC16 in respiratory medicine
Authors: Shapovalova M. M. , Avdeev S. N. , Budnevsky A. V. , Tribuntseva L. V. 
Published: November 2022

One of the most important areas of modern medicine is the search for molecular biomarkers that open up new possibilities in fundamental research of pathological processes, allowing to diagnose human diseases with high accuracy and to implement a personalized approach to prescribe effective therapy. Currently, one of the promising molecular biomarkers in respiratory medicine is club cell protein (CC16, or secretory globulin SCGB1A1). Club-shaped cells are known to be involved in pulmonary homeostasis and regulate the progression of acute and chronic inflammatory processes in the bronchopulmonary system. Immunomodulation and regulation of inflammation by club-shaped cells is mediated by secretion of CC16 protein, which has pronounced anti-inflammatory, anti-allergic, and anti-tumor properties.The aim of the review is to collect and analyze data from recent domestic and foreign studies on the role of club-shaped cells and their CC16 protein in physiological and pathological processes in the airways.Conclusion. Based on the data of domestic and foreign studies presented in the review, it can be concluded that club-shaped cells and their secretory globulin SCGB1A1 play an important role in the physiological and pathological processes in the respiratory tract. Thus, club cell protein may serve as a molecular biomarker for diagnosing and monitoring the progression of certain bronchopulmonary diseases, for individual assessment of the treatment efficacy, and as a basis for the development of new therapies in respiratory medicine.
Various approaches to improving adherence of patients with tuberculosis. Prospects for the use of additive technologies in TB practice
Authors: Naumov A. G. , Shprykov A. S. 
Published: November 2022

Tuberculosis (TB) remains a global problem up to this day. Against the background of the successes achieved in the fight against this infection, many problems have not yet been fully solved. These problems include drug resistance of the pathogen, comorbidity and multimorbidity of TB, the search for new types of drugs, the management and prevention of undesirable side effects of long-term chemotherapy, etc. These problems can only be solved through collaboration between health care professionals and patients. Timely abacillation, closing of decay cavities and stabilization of the clinical condition are practically impossible without such cooperation. Therefore, an important task of phthisiology is to stabilize the patient’s adherence to anti-TB therapy throughout the course of treatment.The aim of the review is to describe existing and innovative ways to improve the level of adherence of TB patients to anti-TB therapy.Conclusion. Current methods to improve adherence of TB patients, both in Russia and other countries, need to be improved and adequately funded. Additive technologies that more effectively reduce the risks of unmotivated discontinuation of polychemotherapy may be the solution.