bluuebunny/crossref_metadata_2025_split huggingface dataset:
On epsilon factorized differential equations for elliptic Feynman integrals
Authors: Frellesvig Hjalte 
Published: March 2022

Abstract
In this paper we develop and demonstrate a method to obtain epsilon factorized differential equations for elliptic Feynman integrals. This method works by choosing an integral basis with the property that the period matrix obtained by integrating the basis over a complete set of integration cycles is diagonal. The method is a generalization of a similar method known to work for polylogarithmic Feynman integrals. We demonstrate the method explicitly for a number of Feynman integral families with an elliptic highest sector.
Subcellular progression of mesenchymal transition identified by two discrete synchronous cell lines derived from the same glioblastoma
Authors: Kim Sojin , Park Soo-Ji , Chowdhury Tamrin , Hong Jeong-Im , Ahn Jinhee , Jeong Tae Yeong , Yu Hyeon Jong , Shin Young-Kyoung , Ku Ja-Lok , Park Jong Bae , Hur Junho K. , Lee Hwajin , Kim Kyoungmi , Park Chul‑Kee 
Published: March 2022

AbstractGlioblastomas (GBM) exhibit intratumoral heterogeneity of various oncogenic evolutional processes. We have successfully isolated and established two distinct cancer cell lines with different morphological and biological characteristics that were derived from the same tissue sample of a GBM. When we compared their genomic and transcriptomic characteristics, each cell line harbored distinct mutation clusters while sharing core driver mutations. Transcriptomic analysis revealed that one cell line was undergoing a mesenchymal transition process, unlike the other cell line. Furthermore, we could identify four tumor samples containing our cell line-like clusters from the publicly available single-cell RNA-seq data, and in a set of paired longitudinal GBM samples, we could confirm three pairs where the recurrent sample was enriched in the genes specific to our cell line undergoing mesenchymal transition. The present study provides direct evidence and a valuable source for investigating the ongoing process of subcellular mesenchymal transition in GBM, which has prognostic and therapeutic implications.
Transcriptional and post-transcriptional control of epithelial-mesenchymal plasticity: why so many regulators?
Authors: Migault Melodie , Sapkota Sunil , Bracken Cameron P. 
Published: March 2022

AbstractThe dynamic transition between epithelial-like and mesenchymal-like cell states has been a focus for extensive investigation for decades, reflective of the importance of Epithelial-Mesenchymal Transition (EMT) through development, in the adult, and the contributing role EMT has to pathologies including metastasis and fibrosis. Not surprisingly, regulation of the complex genetic networks that underlie EMT have been attributed to multiple transcription factors and microRNAs. What is surprising, however, are the sheer number of different regulators (hundreds of transcription factors and microRNAs) for which critical roles have been described. This review seeks not to collate these studies, but to provide a perspective on the fundamental question of whether it is really feasible that so many regulators play important roles and if so, what does this tell us about EMT and more generally, the genetic machinery that controls complex biological processes.
S100A16 promotes acute kidney injury by activating HRD1-induced ubiquitination and degradation of GSK3β and CK1α
Authors: Sun Yifei , Fan Ya , Wang Zheng , Li Min , Su Dongming , Liu Yun , Liang Xiubin 
Published: March 2022

AbstractThe pathogenesis of acute kidney injury (AKI) is associated with the activation of multiple signaling pathways, including Wnt/β-catenin signaling. However, the mechanism of Wnt/β-catenin pathway activation in renal interstitial fibroblasts during AKI is unclear. S100 calcium-binding protein A16 (S100A16), a new member of calcium-binding protein S100 family, is a multi-functional signaling factor involved in various pathogenies, including tumors, glycolipid metabolism disorder, and chronic kidney disease (CKD). We investigated the potential participation of S100A16 in Wnt/β-catenin pathway activation during AKI by subjecting wild-type (WT) and S100A16 knockout (S100A16+/−) mice to the ischemia–reperfusion injury (IRI), and revealed S100A16 upregulation in this model, in which knockout of S100A16 impeded the Wnt/β-catenin signaling pathway activation and recovered the expression of downstream hepatocyte growth factor (HGF). We also found that S100A16 was highly expressed in Platelet-derived growth factor receptor beta (PDGFRβ) positive renal fibroblasts in vivo. Consistently, in rat renal interstitial fibroblasts (NRK-49F cells), both hypoxia/reoxygenation and S100A16 overexpression exacerbated fibroblasts apoptosis and inhibited HGF secretion; whereas S100A16 knockdown or Wnt/β-catenin pathway inhibitor ICG-001 reversed these changes. Mechanistically, we showed that S100A16 promoted Wnt/β-catenin signaling activation via the ubiquitylation and degradation of β-catenin complex members, glycogen synthase kinase 3β (GSK3β) and casein kinase 1α (CK1α), mediated by E3 ubiquitin ligase, the HMG-CoA reductase degradation protein 1 (HRD1). Our study identified the S100A16 as a key regulator in the activation of Wnt/β-catenin signaling pathway in AKI.
First clinical experience with a novel, mobile cone-beam CT system for treatment quality assurance in brachytherapy
Authors: Karius Andre , Strnad Vratislav , Lotter Michael , Kreppner Stephan , Bert Christoph 
Published: March 2022

Abstract
Background and purpose
On-site cone-beam computed tomography (CBCT) has gained in importance in adaptive brachytherapy during recent years. Besides treatment planning, there is increased need particularly for image-guidance during interventional procedures and for image-guided treatment quality assurance (QA). For this purpose, an innovative CBCT device was rolled out at our hospital as the first site worldwide. We present the first clinical images and experiences.

Materials and methods
The novel CBCT system is constructed of a 121 cm diameter ring gantry, and features a 43.2 × 43.2 cm2 flat-panel detector, wireless remote-control via tablet-PC, and battery-powered maneuverability. Within the first months of clinical operation, we performed CBCT-based treatment QA for a total of 26 patients (8 with breast, 16 with cervix, and 2 with vaginal cancer). CBCT scans were analyzed regarding potential movements of implanted applicators in-situ during the brachytherapy course.

Results
With the presented device, treatment QA was feasible for the majority of patients. The CBCT scans of breast patients showed sufficient contrast between implanted catheters and tissue. For gynecologic patients, a distinct visualization of applicators was achieved in general. However, reasonable differentiations of organic soft tissues were not feasible.

Conclusion
The CBCT system allowed basic treatment QA measures for breast and gynecologic patients. For image-guidance during interventional brachytherapy procedures, the current image quality is not adequate. Substantial performance enhancements are required for intraoperative image-guidance.
An SDP-based approach for computing the stability number of a graph
Authors: Gaar Elisabeth , Siebenhofer Melanie , Wiegele Angelika 
Published: March 2022

AbstractFinding the stability number of a graph, i.e., the maximum number of vertices of which no two are adjacent, is a well known NP-hard combinatorial optimization problem. Since this problem has several applications in real life, there is need to find efficient algorithms to solve this problem. Recently, Gaar and Rendl enhanced semidefinite programming approaches to tighten the upper bound given by the Lovász theta function. This is done by carefully selecting some so-called exact subgraph constraints (ESC) and adding them to the semidefinite program of computing the Lovász theta function. First, we provide two new relaxations that allow to compute the bounds faster without substantial loss of the quality of the bounds. One of these two relaxations is based on including violated facets of the polytope representing the ESCs, the other one adds separating hyperplanes for that polytope. Furthermore, we implement a branch and bound (B&B) algorithm using these tightened relaxations in our bounding routine. We compare the efficiency of our B&B algorithm using the different upper bounds. It turns out that already the bounds of Gaar and Rendl drastically reduce the number of nodes to be explored in the B&B tree as compared to the Lovász theta bound. However, this comes with a high computational cost. Our new relaxations improve the run time of the overall B&B algorithm, while keeping the number of nodes in the B&B tree small.
A mobile app for the treatment of female mixed and urgency incontinence: a cost-effectiveness analysis in Sweden
Authors: Ekersund J. , Samuelsson E. , Lindholm L. , Sjöström M. 
Published: March 2022

AbstractIntroduction and hypothesisA previous randomized controlled trial (RCT) demonstrated that the app Tät II, for self-management of mixed urinary incontinence (MUI) and urgency urinary incontinence (UUI), yielded significant, clinically relevant improvements in symptom severity and quality of life (QoL) compared with a control group. We aimed to assess the cost-effectiveness of Tät II.MethodsA cost–utility analysis with a 1-year societal perspective was carried out, comparing Tät II with an information app. Data were collected alongside an RCT: 122 community-dwelling women aged ≥18 years with MUI or UUI ≥2 times/week were randomized to 3 months of Tät II treatment focused on pelvic floor muscle training (PFMT) and bladder training (BT;n= 60), or to an information app (n= 62). Self-assessed data from validated questionnaires were collected at baseline and at 3-month and 1-year follow-ups. Costs for assessment, treatment delivery, incontinence aids, laundry, and time for PFMT and BT were included. We calculated quality-adjusted life-years (QALYs) using the International Consultation on Incontinence Modular Questionnaire Lower Urinary Tract Symptoms Quality of Life. The incremental cost-effectiveness ratio (ICER) between the groups was our primary outcome. Sensitivity analyses were performed.ResultsThe mean age was 58.3 (SD = 9.6) years. Annual overall costs were €738.42 in the treatment group and €605.82 in the control group; annual QALY gains were 0.0152 and 0.0037 respectively. The base case ICER was €11,770.52; ICERs in the sensitivity analyses ranged from €−9,303.78 to €22,307.67.ConclusionsThe app Tät II is a cost-effective treatment method for women with MUI and UUI.
Green function estimates on complements of low-dimensional uniformly rectifiable sets
Authors: David Guy , Feneuil Joseph , Mayboroda Svitlana 
Published: March 2022

AbstractIt has been recently established in David and Mayboroda (Approximation of green functions and domains with uniformly rectifiable boundaries of all dimensions. arXiv:2010.09793) that on uniformly rectifiable sets the Green function is almost affine in the weak sense, and moreover, in some scenarios such Green function estimates are equivalent to the uniform rectifiability of a set. The present paper tackles a strong analogue of these results, starting with the “flagship" degenerate operators on sets with lower dimensional boundaries. We consider the elliptic operators $$L_{\beta ,\gamma } =- {\text {div}}D^{d+1+\gamma -n} \nabla $$

L

β
,
γ

=
-
div

D

d
+
1
+
γ
-
n

∇

associated to a domain $$\Omega \subset {\mathbb {R}}^n$$

Ω
⊂

R

n

with a uniformly rectifiable boundary $$\Gamma $$
Γ
of dimension $$d < n-1$$

d
<
n
-
1

, the now usual distance to the boundary $$D = D_\beta $$

D
=

D
β

given by $$D_\beta (X)^{-\beta } = \int _{\Gamma } |X-y|^{-d-\beta } d\sigma (y)$$

D
β

(
X
)

-
β

=

∫
Γ

|
X
-
y
|

-
d
-
β

d
σ

(
y
)

for $$X \in \Omega $$

X
∈
Ω

, where $$\beta >0$$

β
>
0

and $$\gamma \in (-1,1)$$

γ
∈
(
-
1
,
1
)

. In this paper we show that the Green function G for $$L_{\beta ,\gamma }$$

L

β
,
γ

, with pole at infinity, is well approximated by multiples of $$D^{1-\gamma }$$

D

1
-
γ

, in the sense that the function $$\big | D\nabla \big (\ln \big ( \frac{G}{D^{1-\gamma }} \big )\big )\big |^2$$

|

D
∇

(

ln

(

G

D

1
-
γ

)

)

|

2

satisfies a Carleson measure estimate on $$\Omega $$
Ω
. We underline that the strong and the weak results are different in nature and, of course, at the level of the proofs: the latter extensively used compactness arguments, while the present paper relies on some intricate integration by parts and the properties of the “magical" distance function from David et al. (Duke Math J, to appear).
Differential effects of the translocator protein 18 kDa (TSPO) ligand etifoxine and the benzodiazepine alprazolam on startle response to predictable threat in a NPU-threat task after acute and short-term treatment
Authors: Brunner Lisa-Marie , Maurer Franziska , Weber Kevin , Weigl Johannes , Milenkovic Vladimir M. , Rupprecht Rainer , Nothdurfter Caroline , Mühlberger Andreas 
Published: March 2022

Abstract

Rationale
Benzodiazepines have been extensively investigated in experimental settings especially after single administration, which mostly revealed effects on unpredictable threat (U-threat) rather than predictable threat (P-threat). Given the need for pharmacological alternatives with a preferable side-effect profile and to better represent clinical conditions, research should cover also other anxiolytics and longer application times.

Objectives
The present study compared the acute and short-term effects of the translocator protein 18 kDa (TSPO) ligand etifoxine and the benzodiazepine alprazolam on P-threat and U-threat while controlling for sedation.

Methods
Sixty healthy male volunteers, aged between 18 and 55 years, were randomly assigned to receive a daily dose of either 150 mg etifoxine, 1.5 mg alprazolam, or placebo for 5 days. On days 1 and 5 of intake, they performed a NPU-threat task including neutral (N), predictable (P), and unpredictable (U) conditions, while startle responsivity and self-reports were studied. Sedative effects were assessed using a continuous performance test.

Results
Neither alprazolam nor etifoxine affected startle responsivity to U-threat on any of the testing days. While etifoxine reduced the startle response to P-threat on day 1 of treatment for transformed data, a contrary effect of alprazolam was found for raw values. No effects on self-reports and no evidence of sedation could be observed for either drug.

Conclusions
None of the anxiolytic substances had an impact on startle potentiation to U-threat even after several days of intake. The effects of the anxiolytics on startle responsivity to P-threat as well as implications for future studies are discussed.
Electrochemical sensing of macromolecules based on molecularly imprinted polymers: challenges, successful strategies, and opportunities
Authors: Mazzotta Elisabetta , Di Giulio Tiziano , Malitesta Cosimino 
Published: March 2022

AbstractLooking at the literature focused on molecularly imprinted polymers (MIPs) for protein, it soon becomes apparent that a remarkable increase in scientific interest and exploration of new applications has been recorded in the last several years, from 42 documents in 2011 to 128 just 10 years later, in 2021 (Scopus, December 2021). Such a rapid threefold increase in the number of works in this field is evidence that the imprinting of macromolecules no longer represents a distant dream of optimistic imprinters, as it was perceived until only a few years ago, but is rapidly becoming an ever more promising and reliable technology, due to the significant achievements in the field. The present critical review aims to summarize some of them, evidencing the aspects that have contributed to the success of the most widely used strategies in the field. At the same time, limitations and drawbacks of less frequently used approaches are critically discussed. Particular focus is given to the use of a MIP for protein in the assembly of electrochemical sensors. Sensor design indeed represents one of the most active application fields of imprinting technology, with electrochemical MIP sensors providing the broadest spectrum of protein analytes among the different sensor configurations.Graphical abstract
Molecular characterisation of an atypical coconut-like odour in cocoa
Authors: Porcelli Caterina , Steinhaus Martin 
Published: March 2022

AbstractParallel application of an aroma extract dilution analysis (AEDA) to the volatiles isolated from a sample of fermented cocoa with an atypically pronounced coconut note and to the volatiles isolated from a reference cocoa sample revealed coconut-like smelling compounds δ-octalactone, δ-2-octenolactone, γ-nonalactone, γ-decalactone, δ-decalactone, and δ-2-decenolactone as potential causative odorants. Quantitation of these six compounds and calculation of odour activity values as ratios of the concentrations to the odour threshold values suggested δ-2-decenolactone as the crucial compound. Chiral analysis showed the presence of pure (R)-δ-2-decenolactone, commonly referred to as massoia lactone. Its key role for the coconut note was finally demonstrated in a spiking experiment: the addition of (R)-δ-2-decenolactone to the reference cocoa in an amount corresponding to the concentration difference between the two samples was able to provoke a coconut note in an intensity comparable to the one in the atypically smelling cocoa. To avoid an undesired coconut note caused by (R)-δ-2-decenolactone in the final products, the chocolate industry may consider its odour threshold value, that is 100 µg/kg, as a potential limit for the acceptance of fermented cocoa in the incoming goods inspection.
Bi-Hamiltonian Recursion, Liu–Pandharipande Relations, and Vanishing Terms of the Second Dubrovin–Zhang Bracket
Authors: Iglesias Francisco Hernández , Shadrin Sergey 
Published: March 2022

AbstractThe Dubrovin–Zhang hierarchy is a Hamiltonian infinite-dimensional integrable system associated to a semi-simple cohomological field theory or, alternatively, to a semi-simple Dubrovin–Frobenius manifold. Under an extra assumption of homogeneity, Dubrovin and Zhang conjectured that there exists a second Poisson bracket that endows their hierarchy with a bi-Hamiltonian structure. More precisely, they gave a construction for the second bracket, but the polynomiality of its coefficients in the dispersion parameter expansion is yet to be proved. In this paper we use the bi-Hamiltonian recursion and a set of relations in the tautological rings of the moduli spaces of curves derived by Liu and Pandharipande in order to analyze the second Poisson bracket of Dubrovin and Zhang. We give a new proof of a theorem of Dubrovin and Zhang that the coefficients of the dispersion parameter expansion of the second bracket are rational functions with prescribed singularities. We also prove that all terms in the expansion of the second bracket in the dispersion parameter that cannot be realized by polynomials because they have negative degree do vanish, thus partly confirming the conjecture of Dubrovin and Zhang.
Sharp decreases in survival probabilities in the long-finned pilot whales in Strait of Gibraltar
Authors: Pons Miquel , De Stephanis Renaud , Verborgh Philippe , Genovart Meritxell 
Published: March 2022

AbstractThe Strait of Gibraltar has some of the highest maritime activity in the world. Its populations of cetaceans are threatened by noise, chemical pollution, and collisions by the many boats crossing the strait. One of the greatest threats identified in cetaceans in the Mediterranean are epizootics that severely affect the most sensitive vital rate in long-lived species: adult survival. By a multi-event analysis of a 16-year database of long-finned pilot whale photo identification capture–recapture data, we analysed adult survival in the Strait of Gibraltar’s resident population and evaluated the possible effects of epizootics on this vital rate. We identified the large effect of a morbillivirus epizootic that occurred in 2006–2007, but we also revealed a second collapse in survival in 2011, probably due to another morbillivirus epizootic. These episodes seem to affect sexes differently, with females being less affected than males. Interestingly, the morbillivirus epizootic not only sharply decreased survival after the episode, but the effect extended over time, probably showing post-epizootic sequelae. These disease outbreaks have increased during the last decades worldwide and could be linked to anthropogenic threats such as organochlorine contamination. This may explain the high frequency of epizootics in the Gibraltar area. We warn about the conservation status of this long-finned pilot whale population and recommend the application of measures to reduce contamination on this nutrient-rich area to improve conditions for many marine species inhabiting this area.
Age-Dependent Reference Values for hs-Troponin T and NT-proBNP and Determining Factors in a Cohort of Healthy Children (The LIFE Child Study)
Authors: Kiess Alexandra , Green Jessica , Willenberg Anja , Ceglarek Uta , Dähnert Ingo , Jurkutat Anne , Körner Antje , Hiemisch Andreas , Kiess Wieland , Vogel Mandy 
Published: March 2022

AbstractThis study aimed to provide reliable pediatric reference values for N-terminal pro-brain natriuretic peptide (NT-proBNP) and high-sensitive Troponin T (hsTnT) obtained from a population of well children and investigate for associations with sex, pubertal status, body mass index (BMI), and serum lipid levels. We analyzed hsTnT and NT-proBNP values obtained from 4826 samples provided by 2522 children aged 0.25–18 years participating in a prospective longitudinal population-based cohort study, “LIFE child” in Leipzig, Germany (Poulain et al., Eur J Epidemiol 32:145–158, 2017). NT-proBNP values decreased throughout childhood from values over 400 ng/L at 3 months to 138 ng/L in females and 65 ng/L in males by 18 years of age. Values dropped rapidly with advancing pubertal stage. We found a strong association between lower NT-proBNP values and higher BMI or elevated serum lipids, the latter effect being more pronounced in males. For hsTnT levels, approximately half of the measurements were below the detection limit. However, 76% of those aged 3 months and 21% of those aged 6 months had values exceeding the adult cut-off limit. Females had slightly higher levels in the first 2 years of life but this was reversed during puberty. In males, there was an upward trend from pubertal stage 2 onward. We identified a positive association between hsTnT and BMI but a negative association with low-density lipoprotein (LDL) cholesterol and triglyceride levels in boys but not in girls. Based on a large number of healthy children, we have established reliable reference values for NT-proBNP and hsTnT for use in everyday clinical practice. We have also identified important associations between certain metabolic and cardiac markers.Clinical Trial Registration ClinicalTrial.gov (NCT02550236).