bluuebunny/crossref_metadata_2025_split huggingface dataset:
Phase plate fabrication process to simulate the turbulence effects on an optical imaging system in Korean atmospheric circumstances
Authors: Oh Han-gyol , Kang Pilseong , Lee Jaehyun , Rhee Hyug-Gyo , Ghim Young-sik 
Published: November 2022

Abstract
Telescopes which use light that has propagated through atmospheric paths detect distorted wave generated by atmosphere turbulence. The distorted wave decreases an image quality of the telescope. Adaptive optics technology can be applied to compensate the aberration caused by atmospheric turbulence. However, there are limitations in conducting experiment of the adaptive optical system with real atmosphere. Phase plate is one of the devices that can simulate the real atmosphere in laboratory. We suggest a novel two-step process for fabrication of the phase plate and present a process for manufacturing a phase plate that could simulate atmospheric turbulence similar to the actual atmosphere. The proposed fabrication method does not take additional activities such as a designing phase-screen and a phase simulation. Therefore, anyone can simply and inexpensively produce the phase plate. An analysis is conducted using the statistics of the index of the refraction fluctuation and the modal expansion from Kolmogorov theory. The goal of the experiment is to produce a phase plate for which D/r0 ≈ = 20 and r0 ≈ 7.5 cm. The target of the goal is set in consideration of the Korean atmospheric circumstances. Finally, the phase plate is manufactured by the proposed method, which follows characteristics similar to that of the actual atmosphere.
Safety and efficacy of percutaneous coronary intervention combined with catheter ablation in a single procedure for patients with coronary artery disease complicated with atrial fibrillation
Authors: Chen Lizhu , Liang Tuo , Gao Huikuan , Zhang Heping 
Published: November 2022

Abstract
Background
Coronary artery disease (CAD) always co-exists with atrial fibrillation (AF). A new delivery of cardiac interventions for patients is needed during or even after the 2019 coronavirus disease (COVID-19) pandemic. This study aimed to evaluate the safety and efficacy of percutaneous coronary interventions (PCI) combined with AF catheter ablation (AFCA) in a single procedure for patients with CAD and AF.
Methods
From Jan 2020 to Jun 2021, 40 consecutive patients who underwent both PCI and AFCA were retrospectively enrolled for this study. All patients were followed up 1, 3, 6, and 12 months after the procedure. The primary safety outcomes included cardiac tamponade, cerebrovascular accident/stroke, transient ischemic attack (TIA), thromboembolism, myocardial infarction, vascular access site complications, and bleeding. The primary efficacy outcomes included 12-month AF recurrence and in-stent restenosis (ISR).
Results
Six adverse events were reported, including small hematoma at the groin access site in two cases, minor bleeding in three cases, and stroke not related to the procedure in one case. No ISR was reported. The Kaplan-Meier analysis estimated that the AF-free success rate at 12 months was 95.7% in paroxysmal atrial fibrillation (PAF) patients and 64.7% in those with persistent atrial fibrillation (PsAF).
Conclusions
The combination of PCI and AFCA in one procedure was feasible, safe, and efficacious in patients with CAD and AF. The combined procedure can be recommended in clinical practice, during or even after the COVID-19 era.
Highly Realistic Whole Transcriptome Synthesis through Generative Adversarial Networks
Authors: Fu Suneng 
Published: November 2022

Abstract
The transcriptome is the most extensive and standardized among all biological data, but its lack of inherent structure impedes the application of deep learning tools. This study resolves the neighborhood relationship of protein-coding genes through uniform manifold approximation and projection (UMAP) of high-quality gene expression data. The resultant transcriptome image is conducive to classification tasks and generative learning. Convolutional neural networks (CNNs) trained with full or partial transcriptome images differentiate normal versus lung squamous cell carcinoma (LUSC) and LUSC versus lung adenocarcinoma (LUAD) with over 96% accuracy, comparable to XGBoost. Meanwhile, the generative adversarial network (GAN) model trained with 93 TcgaTargetGtex transcriptome classes synthesizes highly realistic and diverse tissue/cancer-specific transcriptome images. Comparative analysis of GAN-synthesized LUSC and LUAD transcriptome images show selective retention and enhancement of epithelial identity gene expression in the LUSC transcriptome. Further analyses of synthetic LUSC transcriptomes identify a novel role for mitochondria electron transport complex I expression in LUSC stratification and prognosis. In summary, this study provides an intuitive transcriptome embedding compatible with generative deep learning and realistic transcriptome synthesis.
Computed Tomography Analysis of Acetabular Component Anteversion after Total Hip Arthroplasty: Conventional Axial versus Functional Coronal Plane
Authors: Lee Sang-Min , Shin Won Chul , Moon Nam Hoon , Do Min Uk , Kim Jung Shin , Suh Kuen Tak 
Published: November 2022

Abstract
Aims: This study aimed to compare the accuracy and reliability of computed tomography (CT) anteversion measurements between the conventional axial plane (CAP) and functional coronal plane (FCP).
Methods: We retrospectively reviewed 68 patients who underwent primary unilateral total hip arthroplasty (THA) and postoperative CT. Values obtained using PolyWare software were considered the reference standard. The anteversion of the acetabular component was measured in the CAP as anatomical anteversion and in the reformatted FCP as radiographic anteversion using a reconstruction software. Reliability was assessed using the intraclass correlation coefficient.
Results: The mean anteversion of the acetabular component in the CAP and FCP CT images was 29.18° ± 6.06° and 21.17° ± 5.38°, respectively. The CT anteversion measurement was more accurate in the reformatted FCP than in the CAP owing to its similarity with the reference standard (20.70° ± 4.39°, p = 0.281). The CT anteversion was larger in the CAP than in the FCP, showing a significant linear correlation and a difference of 8.01°. The intra- and interobserverreliabilities were excellent for all measurement methods.
Conclusion: The reformatted FCP CT image is useful in the accurate measurement of anteversion after THA. This study will also help measure anteversion through CT.
Effect of Crataegus Azarolus on blood glucose, lipid profile and antioxidant status in streptozotocin diabetic rats fed zinc deficient diet
Authors: Triki Ramzi , Boughediri Khaoula , Chelaghmia Mohamed Lyamine , Kechrid Zine 
Published: November 2022

Abstract
Objective
zinc plays an important role in insulin's biosynthesis and storage. Consequently, its deficiency may have a deleterious impact on the progression of diabetes and associated consequences. Thus, this study was conducted to investigate the effect of Hawthorn “Crataegus Azarolus” on blood biochemical parameters, tissue zinc status, and oxidative stress biomarkers in streptozotocin diabetic rats fed zinc insufficient diet.
Methods
Thirty-two males albino Wistar rats were divided into 4 groups: 2 groups were fed zinc-sufficient diet (One non-diabetic and the other diabetic), while the others 2 groups of diabetic rats were fed zinc insufficient diet. One non-treated group and the other treated with the extract of Crataegus Azarolus (150mg/kg Body weight). Body weight and food intake were recorded regularly. After 4 weeks of dietary manipulation, fasting animals were scarified
Results
zinc deficiency feed decreased body-weight, insulin, zinc tissues (femur, liver, kidney, and pancreas), glutathione concentrations, lactic dehydrogenase, catalase, superoxide dismutase, glutathione peroxidase and glutathione reductase activities. It was also noticed that inadequate dietary zinc intake increased concentrations of glucose, cholesterol, triglycerides, urea, uric acid, creatinine, lipid peroxidation levels, and transaminases activities. However, oral administration of hawthorn extract ameliorated all the previous parameters approximately to their normal levels.
Conclusion
the present study showed that Crataegus Azarolus supplementation presumably acting as an antioxidant, and it can be a natural source for the reduction of diabetes development caused by zinc deficiency.
Identification of a DAMP receptor and its cognate peptide ligand in sweet potato (Ipomoea batatas)
Authors: Lu Hsueh-Han , Meents Anja , Fliegmann Judith , Hwang Ming-Jing , Suen Ching-Shu , Felix Georg , Mithöfer Axel , Yeh Kai-Wun 
Published: November 2022

Abstract
Sweet potato (Ipomoea batatas) is an important tuber crop, but also target of numerous insect pests. Intriguingly, the abundant storage protein in tubers, sporamin, has intrinsic trypsin protease inhibitory activity. In leaves, sporamin is induced by wounding or a volatile homoterpene and enhances insect resistance. While the signaling pathway leading to sporamin synthesis is partially established, the initial event, perception of a stress-related signal is still unknown. Here, we identified a leucine-rich repeat receptor kinase (IbLRR-RK1) that is induced upon wounding and herbivory, and related to peptide-elicitor receptors (PEPRs) from tomato and Arabidopsis. We also identified a gene encoding a precursor protein comprising a peptide ligand (IbPep1) for IbLRR-RK1. IbPep1 represents a distinct signal in sweet potato, which might work in a complementary and/or parallel pathway to the previously described HypSys peptides to strengthen insect resistance. Notably, an inter-family compatibility in the Pep/PEPR system from Convolvulaceae and Solanaceae was identified.
Pancreatic cancer cells crave glutamine for glycosylation and CA19-9 biosynthesis through hexosamine biosynthetic pathway
Authors: Liu Chen , Deng Shengming , Xiao Zhiwen , Lu Renquan , Cheng He , Feng Jingjing , Shen Xuxia , Ni Quanxing , Wu Weiding , Yu Xianjun , Luo Guopei 
Published: November 2022

Abstract
Background: Carbohydrate antigen 19-9 (CA19-9) is the most widely used biomarker for pancreatic cancer. Since CA19-9 closely correlates with patient outcome and tumor stage in pancreatic cancer, the deciphering of CA19-9 biosynthesis provides a potential clue for treatment.
Methods: Concentration of amino acids was detected by ultrahigh-performance liquid chromatography tandem mass spectrometry. Metabolic flux of glutamine was examined by isotope tracing untargeted metabolomics. Label-free quantitative N-glycosylation proteomics was used to examine N-glycosylation alterations.
Results: Among all amino acids, glutamine was higher in CA19-9-high pancreatic cancers (> 37 U/mL, 66 cases) than in CA19-9-normal clinical specimens (≤ 37 U/mL, 37 cases). The glutamine concentration in clinical specimens was positively correlated with liver metastasis or lymphovascular invasion. Glutamine blockade using diazooxonorleucine suppressed pancreatic cancer growth and intraperitoneal and lymphatic metastasis. Glutamine promotes O-GlcNAcylation, protein glycosylation, and CA19-9 biosynthesis through the hexosamine biosynthetic pathway. UDP-N-acetylglucosamine (UDP-GlcNAc) was an intermediate product between glutamine and CA19-9.
Conclusions: Pancreatic cancer cells crave glutamine for CA19-9 biosynthesis. Glutamine blockade may be a potential therapeutic strategy for pancreatic cancer.
Digitally restored damaged Bodhisattva statue from the Tang Dynasty in Longmen Grottoes
Authors: xiaoshu li , Yusof Mohd Johari Mohd , Hiong Ser Wue , Perumal Velu , Xiufeng Wang 
Published: November 2022

Abstract
Bodhisattvas has the highest level in practice, which is second only to or equal to Buddha. Because of the special status of the Bodhisattva, most of the statues are beside the Buddha. It is also because of her importance that she has become the first choice of many grave robbers. The heads of many existing Bodhisattva statues have been stolen. Besides that, due to environmental and other factors, many Buddha statues have been unreasonably damaged. In order to prevent secondary damage and let future generations still enjoy this magnificent art after hundreds of years, this paper will digitally restore this valuable statue. In this paper, firstly, the facial features of the same type of Bodhisattva were analyzed by MEGVII "face++" software to obtain the angle extremes of the restored data. Then, the facial features analyzed by systematic literature review(SLR) method were used for artistic processing to make it closer to the original appearance of Buddha statue. Notably, the digital restoration of the damaged Bodhisattvas could provide a new approach to the restoration plan and basis for the digitization of Longmen Grottoes. This form of restoration is also able to organically combine modern science and technology with traditional art research, which offers a new academic research method for restoring traditional art history.
Epigenetic silencing of HOXA4 gene is associated with imatinib resistance, disease progression, BCR-ABL1 transcript type and smoking status among Chronic Myeloid Leukemia patients
Authors: Radin Dariush , Hamid Mohammad , Kargar Mohammad , Jafarinia Mojtaba 
Published: November 2022

Abstract
Background
We aimed to investigate the role of HOXA4 gene methylation concerning response to imatinib, and chronic myeloid leukemia (CML) progression, also investigated the impact of the type of BCR-ABL1 transcript and smoking on methylation level.
Methods
45 CML patients at different clinical stages of the disease (including 20 good responses and 25 non-mutated imatinib-resistant patients) and 15 health controls were recruited. Methylation level of HOXA4 gene promoter was evaluated by Methylation Sensitive High-Resolution Melt (MS-HRM) analysis.
Results
There was a significant difference in the mean of HOXA4 methylation percentage between two response groups (mean = 63.8; SD = 17.79 vs mean = 47.75; SD = 14.18, P = 0. 002). HOXA4 promoter hypermethylation (51–100% methylation level) indicated a higher risk for progression to advance phase (OR = 5.75; 95% CI: 1.40-23.49; P = 0.01) and imatinib resistance (OR = 8.5; 95% CI: 1.96–36.79; P = 0.004). Importantly, the patients with b2a2 transcript and smokers were associated with a higher percentage of HOXA4 methylation (OR = 7.08; 95% CI, 1.80-27.79; P = 0.005, OR = 11.8; 95% CI, 2.67–52.67; P = 0.001 respectively).
Conclusion
Our study suggests the association of the HOXA4 gene hypermethylation with imatinib resistance and CML progression. Moreover, the BCR-ABL1 transcript type and smoking have an impact on methylation levels.
The Effect of Mechanical Ventilation Modes on Salivary Cortisol Levels of Premature Babies
Authors: Satar Mehmet , Kaplan Selin , Tuli Abdullah , Aydın Ümmühan Fulden , Yıldızdaş Hacer Yapıcıoğlu , Narlı Nejat 
Published: November 2022

Abstract
Objective: Respiratory failure is common in preterm infants and mechanical ventilation treatment may be required. Pain and stress in newborns during mechanical ventilation may have negative effects on neurological development of the babies. Salivary cortisol level is one of the important non-invasive tests to detect stress. In this study, we aimed to examine the relationship between mechanical ventilation modes and stress levels by measuring salivary cortisol level of the preterm infants.
Methods: The study group consisted of 65 preterm infants on respiratory support, and 43 control preterm infants. Neonatal Infant Pain Scale (NIPS) was used to evaluate the pain. To determine the stress level, salivary cortisol level was studied in saliva samples taken in the morning and in the evening on the 4th postnatal day.
Results: The morning and evening salivary cortisol levels of the infants in the study group were found to be significantly higher than the babies in the control group (p<0.001; p<0.001, respectively). Both morning and evening salivary cortisol levels of infants on invasive mechanical ventilation were found to be higher than the cortisol values of infants on non-invasive mechanical ventilation (p<0.001; p<0.001, respectively). Pressure Support mode and Synchronised Intermittant Positive Pressure Ventilation mode did not differ in cortisol levels either in the morning or in the evening (p=0.402; p=0.391, respectively). However in non-invasive modes, nasal Synchronised Intermittant Mandatory Ventilation caused higher cortisol levels compared to nasal Continous Positive Pressure Ventilation mode both in the morning and in the evening samples (p=0.031; p=0.038, respectively).
Conclusion: Increased salivary cortisol levels in invasive modes show that intubation causes pain and stress in newborns. For this reason, we assume that physicians and nurses have important duties for the pain and stress management of infants undergoing mechanical ventilation.
Coping with abrasion and structural failure – diverging composition of radular teeth in two Porifera-consuming nudibranch species (Mollusca, Gastropoda)
Authors: Krings Wencke , Wägele Heike , Neumann Charlotte , Gorb Stanislav N. 
Published: November 2022

Abstract
Background: Most molluscs forage with their radula, a chitinous membrane with embedded teeth. As teeth are interfaces between the individual and its ingesta, trophic specialisations can be reflected by morphology, composition, and mechanical properties of the radula. Adaptations to the ingesta – especially with regard to mechanisms contributing to the reduction of structural failure and wear – are well studied in the heavily mineralized teeth of Polyplacophora and Patellogastropoda. For the rather chitinous teeth of non-limpet snails, we are however confronted with a large gap of knowledge.
Results: For this study, we selected nudibranch gastropods, which are of high interest, when studying trophic specialisations, because taxa are strongly adapted to forage on certain prey types. To shed some light on this type of radula, we here investigated two species – Felimare picta and Doris pseudoargus, which are similar with regard to their food preference (Porifera-consuming). Tooth morphologies were documented using scanning-electron-microscopy and mechanical properties were tested by nanoindentation, to develop hypotheses on functional adaptations of the radula to the ingesta. We found that tooth morphologies and mechanical properties are rather similar in both species, indicating that teeth are similar in their function. In the search for the reasons of the specific mechanical properties, we studied the material composition. Teeth were visualized using confocal laser scanning microscopy (CLSM), to determine the degree of tanning, and analysed with energy-dispersive X-ray spectroscopy (EDX), to determine the elemental composition. Our results show, that the inorganic content and the emitted autofluorescence signal differ between the species. This was especially prominent, when studying the inner and outer sides (leading and trailing edges) of teeth. In F. picta, we detected high proportions of Si, whereas teeth of D. pseudoargus contained high amounts of Ca, which influenced the autofluorescence signal in CLSM. Using nanoindentation we determined high Young’s modulus and hardness values for the leading edges of teeth, which seem to correlate with the Si- and Ca-content.
Conclusions: This is a new set of data for non-limpet gastropods, rendering that their teeth can be mechanically enhanced via different chemical pathways to reach similar properties in reducing structural failure and abrasion.
Examining the quality of news media reporting of complex mental illness in relation to violent crime in Australia
Authors: Graham Madeline , Ross Anna , Morgan Amy , Paton Elizabeth 
Published: November 2022

Abstract
Purpose

News reporting on mental illness can perpetuate stigma. An understanding of the current picture of such reporting is important to identify areas for improvement. This study investigated the quality of Australian news media coverage of complex mental illness in the context of crime and violence over a 2-year period, prior to the release of new media guidelines.

Methods

This research utilised a systematic search of Australian news articles that were published between July 2018 and July 2020 and reported on mental illness in relation to violent crime. Researchers developed a Mental Illness and Crime Reporting Quality Framework to determine quality scores for news articles according to 11 relevant factors in media guidelines. An additional 11 characteristics of articles were extracted for further descriptive analysis.

Results

One-hundred and twenty-eight Australian news articles met inclusion criteria. The average quality score was 50 (SD = 13.91) out of a possible maximum score of 100 (range 11 – 78). Strengths and weaknesses were identified as some criteria were consistently met, and other criteria were met rarely or not at all. There were emerging trends between quality scores and article characteristics, including publication source, though these analyses were not statistically significant.

Conclusion

The findings indicate that Australian news coverage of complex mental illness and violent crime met half of the criteria of reporting guidelines that minimises risk of perpetuating or reinforcing stigma. This demonstrates significant opportunity to improve the overall quality of media reporting on crime and mental illness. Future research should evaluate the impact of the guidelines on the quality of news reporting after their implementation by utilising a similar methodology, using these findings as a baseline measure.