bluuebunny/crossref_metadata_2025_split huggingface dataset:
PENGARUH PRAKTIK KERJA INDUSTRI, PRESTASI BELAJAR DAN MOTIVASI MEMASUKI DUNIA KERJA TERHADAP KESIAPAN KERJA SISWA KELAS XI SMK
Authors: Wibowo Rizal Eko , Santoso Jarot Tri Bowo , Widiyanto Widiyanto 
Published: January 2022

Tujuan penelitian ini adalah untuk menguji pengaruh prakerin, prestasi belajar di sekolah, dan motivasi memasuki kerja terhadap kesiapan kerja. Populasi dalam penelitian ini adalah siswa kelas XI SMK Palebon Semarang. Jumlah populasi dari penelitian sebanyak 283 siswa dan sampel 166 siswa yang dihitung berdasarkan rumus Slovin dengan taraf kesalahan 5%. Metode pengumpulan data menggunakan observasi, dokumentasi dan kuesioner. Metode analisis data menggunakan analisis regresi berganda, analisis uji hipotesis, dan analisis deskriptif persentase dengan menggunakan bantuan program SPSS for Windows Release 20. Hasil penelitian menunjukkan bahwa analisis regresi berganda diperoleh persamaan Y = 30,773 + 0435X1 + 0,414X2 + 0,2147X3 + e. Secara simultan prakerin, prestasi belajar di sekolah, dan motivasi memasuki dunia kerja berpengaruh positif dan signifikan terhadap kesiapan kerja sebesar 50,9%. Sedangkan secara parsial untuk prakerin (praktik kerja industri) berpengaruh positif dan signifikan terhadap kesiapan kerja sebesar 40,83%, prestasi belajar di sekolah berpengaruh positif dan siginifikan terhadap kesiapan kerja sebesar 2,75%, dan motivasi memasuki dunia kerja berpengaruh berpengaruh positif dan siginifikan terhadap kesiapan kerja sebesar 2,72%.
Pengaruh Personality Motivation, Self-Efficacy, dan Career Adaptability Terhadap Komitmen Karir
Authors: Nuraini Umi , Susilowati Nurdian , Khoirunnisa Khoirunnisa , Ananda Delya Saski , Febriyanti Ika Dian Anggraini 
Published: January 2022

Tujuan penelitian ini adalah untuk mengetahui pengaruh minat intrinsik seperti personality motivation, self-efficacy dan career adaptability terhadap komitmen karir. Populasi dalam penelitian ini adalah mahasiswa Pendidikan Akuntansi Universitas Negeri Semarang Tahun Angkatan 2018. Desain penelitian dalam penelitian ini adalah kuantitatif. Jumlah populasi Mahasiswa Pendidikan Akuntansi adalah 119 mahasiswa. Sampel yang digunakan yaitu proportional random sampling. Diperoleh sebanyak 80 sampel. Teknik pengumpulan data menggunakan kuesioner google form secara online. Teknik analisis data yang digunakan adalah analisis regresi berganda dengan bantuan alat IBM SPSS 22. Hasil penelitian ini menunjukkan personality motivation, self-efficacy dan career adaptability secara simultan memiliki pengaruh terhadap dalam kategori cukup. Berdasarkan hasil uji hipotesis penelitian ini, dari keempat hipotesis yang diajukan terdapat tiga hipotesis diterima dan satu hipotesis ditolak. Personality motivation dan career adaptability masing-masing memiliki pengaruh signifikan terhadap komitmen karir profesi guru akuntansi pada mahasiswa pendidikan akuntansi. Sedangkan, self-efficacy tidak memiliki pengaruh signifikan terhadap komitmen karir profesi guru akuntansi pada mahasiswa pendidikan akuntansi. Penelitian ini memiliki jangkauan wilayah penelitian yang kecil. Sehingga, Penelitian belum dapat secara maksimal mengukur komitmen karir Pendidikan di Universitas Negeri Semarang untuk setiap tahun angkatan yang ada.
Pengaruh Bahan Baku, Tenaga Kerja dan Kemampuan Manajerial Terhadap Jumlah Produksi Tahu
Authors: Azizah Nur , Setiaji Khasan 
Published: January 2022

One most influential things about the total production is the factors of production.This research aims to determine the effect of raw materials, labor, and managerial ability on the total production of tofu in Adiwerna Village, Adiwerna district, Tegal. The population in this study were tofu craftsmen in Adiwerna Village, Adiwerna district, Tegal Regency in the amount of 319 craftsmen and obtained sample of 76 people using simple random sampling. Data collection tool was the questionnaire or questionnaire method. analysis. The result of the research shows that there is influence between raw materials, labor, and managerial ability to total production either simultaneously or partially. The simultaneous effect of 0,518 or 59,1% whereas 40,9% is explained by other factors. Partially raw material , labor, and managerial ability to the total production are 14,67%, 16,31%, and 7,73%. The conclusion of this research is there is positive and significant influence between raw materials, labor, and managerial ability to total production. The suggestions of this study are Tofu craftsmen must pay attention to the availability of raw materials when the prices increase, they can augment labor productivity well and improve their capabilities so that the level of production can be maintained both in quantity and quality.
Tumour detection and outcomes of surveillance screening in SDHB and SDHD pathogenic variant carriers
Authors: White Gemma , Velusamy Anand , Anandappa Samantha , Masucci Michael , Breen Louise A , Joshi Mamta , McGowan Barbara , Hubbard Johnathan G H , Obholzer Rupert , Christodoulou Dimitra , Jacques Audrey , Touska Philip , Hassan Fahim-Ul , Izatt Louise , Carroll Paul V 
Published: January 2022

Objective
Succinate dehydrogenase subunit (SDHx) pathogenic variants predispose to phaeochromocytoma and paraganglioma (PPGL). Lifelong surveillance is recommended for all patients to enable prompt detection and treatment. There is currently limited evidence for optimal surveillance strategies in hereditary PPGL. We aim to detail the clinical presentation of PPGL in our cohort of non-index SDHB and SDHD pathogenic variant carriers.

Methods
Retrospective analysis of medical and genetic records from a single tertiary referral centre identified SDHB or SDHD pathogenic variants in 74 non-index cases (56 SDHB and 18 SDHD). Surveillance screening for asymptomatic relatives consisted of annual plasma metanephrine measurement and whole-body MRI with contrast at 3–5 yearly intervals.

Results
Twenty-three out of 74 non-index patients (10 SDHB and 13 SDHD) were diagnosed with PPGL, 17 patients through surveillance screening (24 tumours in total) and 6 diagnosed prior to commencement of cascade screening with symptomatic presentation. MRI with contrast identified PPGL in 22/24 screen-detected tumours and 5/24 tumours had elevated plasma metanephrine levels. Penetrance in non-index family members was 15.2 and 47.2% for SDHB carriers and 71.6 and 78.7% for SDHD carriers at age of 50 and 70 years, respectively.

Conclusion
Surveillance screening with combined biochemical testing and imaging enables early detection of PPGL in asymptomatic relatives with SDHx pathogenic variants. The presence of disease at first screen was significant in our cohort and hence further multi-centre long-term data are needed to inform counselling of family members undergoing lifelong surveillance.
Initial or salvage treatment with apatinib shows promise against radioiodine-refractory differentiated thyroid carcinoma
Authors: Qiu Xian , Cheng Lin , Sa Ri , Fu Hao , Jin Yuchen , Chen Libo 
Published: January 2022

Objective
Sorafenib and lenvatinib have been recommended as standard tyrosine kinase inhibitors (TKIs) for progressive radioiodine-refractory differentiated thyroid carcinoma (RR-DTC). However, their efficacy remains limited with unresolved drug resistance. Therefore, we conceived this open-label study based on real-world evidence to investigate the efficacy and safety of apatinib in patients with progressive RR-DTC.

Methods
Off-label use of apatinib as either initial treatment or salvage treatment for sorafenib resistance was investigated. The primary endpoint was progression-free survival (PFS) and the secondary endpoints included objective response rate (ORR), overall survival (OS), and safety.

Results
For all 28 enrolled patients, the median PFS was 15.1 months, with an ORR of 69.6%. The median OS was not reached at the data cut-off. In detail, the median PFS of 17.3 months and the ORR of 75% were determined in patients with TKI-naive RR-DTC (initial treatment group, n  = 14). And, in patients with first-line sorafenib-resistant RR-DTC (salvage treatment group, n  = 14), a median PFS of 12.0 months was reached, with an ORR of 45.5%. In the salvage treatment group, the median OS from the start of apatinib administration was 20.6 months, reaching 89.1 months from sorafenib treatment initiation. Adverse events at grade 3 or higher occurred in 64.3% of all subjects treated with apatinib.

Conclusions
This study demonstrated that apatinib shows promise against RR-DTC with tolerable toxicity, representing a novel initial treatment for progressive RR-DTC and effective salvage treatment for RR-DTC resistant to sorafenib.
Importance of cortactin for efficient epithelial NF-ĸB activation by Helicobacter pylori, Salmonella enterica and Pseudomonas aeruginosa, but not Campylobacter spp.
Authors: Tegtmeyer Nicole , Soltan Esmaeili Delara , Sharafutdinov Irshad , Knorr Jakob , Naumann Michael , Alter Thomas , Backert Steffen 
Published: January 2022

Abstract
Transcription factors of the nuclear factor kappa‐light‐chain‐enhancer of activated B cells (NF-ĸB) family control important signaling pathways in the regulation of the host innate immune system. Various bacterial pathogens in the human gastrointestinal tract induce NF-ĸB activity and provoke pro-inflammatory signaling events in infected epithelial cells. NF-ĸB activation requires the phosphorylation-dependent proteolysis of inhibitor of ĸB (IĸB) molecules including the NF-ĸB precursors through ubiquitin-mediated proteolysis. The canonical NF-ĸB pathway merges on IĸB kinases (IKKs), which are required for signal transduction. Using CRISPR-Cas9 technology, secreted embryonic alkaline phosphatase (SEAP) reporter assays and cytokine enzyme-linked immunosorbent assay (ELISA), we demonstrate that the actin-binding protein cortactin is involved in NF-ĸB activation and subsequent interleukin-8 (IL-8) production upon infection by Helicobacter pylori, Salmonella enterica and Pseudomonas aeruginosa. Our data indicate that cortactin is needed to efficiently activate the c-Sarcoma (Src) kinase, which can positively stimulate NF-ĸB during infection. In contrast, cortactin is not involved in activation of NF-ĸB and IL-8 expression upon infection with Campylobacter species C. jejuni, C. coli or C. consisus, suggesting that Campylobacter species pluralis (spp.) induce a different signaling pathway upstream of cortactin to trigger the innate immune response.
La motivación y el estudio de la función cuadrática con GeoGebra®
Authors: Rodriguez-Mendoza Ramiro , Suárez Oscar Jardey 
Published: January 2022

Objetivo: Describir las variables subyacentes de la motivación y estilos atribucionales de los estudiantes de educación básica de un colegio privado en Bogotá-Colombia, cuando estudian la función cuadrática apoyados en el software de Geometría dinámica GeoGebra®. Método: con enfoque metodológico mixto. Se utiliza el inventario CEAP-48, de forma adicional se realiza una entrevista a un grupo focal. Los resultados se analizan bajo el Análisis de componentes principales con la confiabilidad interna de coeficiente global α de Cronbach. Resultados: el examen como motivación y el aprendizaje y su utilidad se mantienen como variables subyacentes a la motivación, en tanto que la calificación como motivación emerge como variable después de la implementación de la Secuencia Didáctica. GeoGebra®, en el decir de los estudiantes, es un elemento de motivación y mediación toda vez que permite experimentar, comprobar y visualizar algunas conjeturas. Discusión y Conclusiones: Las categorías propias del instrumento CEAP-48 muestran los mismos resultados en el pretest y postest de la investigación como en el de los autores del mismo, lo que indica que el instrumento tiene una validez diacrónica en el tiempo. Además, el examen hace parte de la motivación del estudiante, logrando afectar sus emociones en la academia.
The Role of Artificial Intelligence in the Formation of Platform Law and its Evolution towards the Concept of Ecosystem Law
Authors: Kashkin S. Yu. , Altukhov A. V. 
Published: January 2022

Digitalization is, perhaps, a distinct marker of our time, embodying modern values and vectors of development of economic and social processes in societies and states. However, the modern scientific and technological revolution, which significantly changes the architecture and functionality of the platform law that is being formed before our eyes, invariably entails the evolution of legal concepts that improve the regulation of innovations that appear in connection with its development. The popularity and a kind of indispensability of artificial intelligence technologies in everyday life naturally requires a legal assessment of the use of smart technologies and the creation of the necessary legal conditions for effective interaction of society with network law, platform solutions and ecosystems. The paper analyzes the impact of the introduction of artificial intelligence technologies into modern digital platforms from the point of view of the transformation of the needs for legal regulation and the evolution of platform law as an important legal regulator of the development of digital ecosystems for various purposes, which gives grounds to put forward the concept of the beginning of the process of formation of ecosystem law.The authors draw attention to the fact that platform law competes with the law of the state and leads to the improvement of AI, which threatens the very existence of a person. As a result, there is a need to limit AI in the interests of ensuring human security, which is possible only within the framework of a new, «environmentally friendly» human system, i.e., an ecosystem functioning in the interests of man and humanity. In turn, such a system cannot exist without a new ecosystem law, the development of which legal science can and should predict.
Application of the Principles of Contract Law to Contractual Relations complicated by a Digital Element
Authors: Suvorov E. D. 
Published: January 2022

The paper is devoted to the application of the principles of law in contractual relations, the emergence or implementation of which are associated with the use of digital means. The development of digital technologies has caused objective changes in the structure and qualities of economic turnover. At the same time, objective changes mean those that are formed due to changes in the behavior of private entities at the micro level.The author substantiates the thesis according to which, in conditions of a lack of regulatory regulation, the relevant principles of law are in demand sources of law for resolving potential conflicts of interest. The author states that in conditions when the main categories of civil law are being revised — subjects (identity identification), objects (tokenization), transactions (ways of expressing will in the digital economy), fulfillment of obligations (smart contracts), the main thing that law will remain unchanged is its principles. The principles of law are lawthemselves; the rest is either changing forms of relations that law affects, or a changing mechanism for the implementation of legal ideas. In turn, it is the principles of law that contain invariable methods of resolving conflicts of interest, which is the main subject of law. Complicating the contractual relationship with a digital element not only does not cancel the application of principles to such relations, but at the stage of insufficient regulatory regulation as a means of implementing the principles of law requires their active use to resolve conflicts of interest.The paper classifies some cases of digital means application at the stage of concluding a contract, fulfilling obligations, and enforcement. The potential of the principles of law for resolving disputable situations in digital contractual relations at each stage of the development of contractual legal relations is shown.
Formas de la corporalidad en el pensamiento ilustrado entre España y América Latina
Authors: Morgan Muriel , Sidy Bettina , Vacca Laura Celina 
Published: January 2022

Este trabajo presenta una serie de avances de investigación en torno a la corporalidad en el contexto de las reformas borbónicas en los reinos de España. Las políticas contenidas en estas reformas implicaron un cambio sustantivo en la gestión, la representación y el manejo de los cuerpos desde las esferas de gobierno. Los pensadores de la Ilustración española fueron en esta dirección, buscando intervenir los cuerpos para interiorizar un ideal corporal ligado a la robustez, la habilidad, la fortaleza, los trabajos manuales y la disciplina para el trabajo. En esta oportunidad, el centro de análisis son tres pensadores paradigmáticos de este proceso; Campomanes, Jovellanos y Cabarrús. Mediante mecanismos específicos, ligados a instituciones determinadas, ellos propusieron una interiorización de un modelo de corporalidad ideal. El presente argumenta que, en la perspectiva de estos autores, la mente y el cuerpo debían ser alimentados de manera pragmática con el fin de modelar ciudadanos útiles en términos de productividad.
ANALISIS PERBANDINGAN KINERJA KEUANGAN BANK BNI SYARIAH DAN BANK SYARIAH MANDIRI DI MASA PANDEMI COVID-19
Authors: Surya Yoga Adi , Asiyah Binti Nur 
Published: January 2022

Financial performance as a measurement to determine the process of implementing financial resources owned by the company. Covid-19 pandemic has an impact on the banking sector, resulting in non-performing financing due to debtor arrears as a result of many people losing their jobs and difficulties in paying credit. This study has the objective of analyzing the comparative financial performance between Mandiri Shariah Bank and BNI Shariah Bank during the Covid-19 pandemic, using quarterly financial statements 1, 2, 3 and 4 for 2019 and quarter 1 for 2020 and through Independent testing T-Test sample. There are financial performance differences between BNI Shariah Bank and Mandiri Shariah Bank from ROA, NPF and BOPO aspects, whereas in terms of CAR and ROE aspects show significantly there are no differences performances between BNI Shariah Bank dan Mandiri Shariah Bank. This paper recommends that BNI Syariah pay attention to the ROE and NPF ratio, while to Bank Syariah Mandiri to pay attention to the CAR, ROA and BOPO ratios. Kinerja keuangan sebagai alat ukur untuk mengetahui proses melaksanakan sumberdaya keuangan yang dipunyai oleh perusahaan. Pandemi Covid-19 berdampak pada sektor perbankan sehingga mengakibatkan pembiayaan tidak lancar karena penunggakan debitur sebagai akibat dari banyaknya masyarakat kehilangan pekerjaan dan kesulitan untuk pembayaran pembiayaan. Penelitian ini mempunyai tujuan yakni melakukan analisis perbandingan kinerja keuangan antara Bank Syariah Mandiri dengan Bank BNI Syariah selama pandemi Covid-19, dengan menggunakan catatan laporan keuangan triwulan 1, 2, 3 dan 4 untuk tahun 2019, triwulan 1 untuk tahun 2020 dengan melalui pengujian Independen Sampel T-Test. Terdapat perbedaan antara kinerja keuangan Bank BNI Syariah dan Bank Syariah Mandiri dari aspek ROA, NPF dan BOPO, dan sedangkan dari segi aspek CAR dan ROE menunjukkan bahwa secara signifikan tidak ada perbedaan antara kinerja keuangan Bank Syariah Mandiri dan Bank BNI Syariah. Paper ini merekomendasikan kepada BNI Syariah agar memperhatikan rasio ROE dan NPF, sedangkan kepada Bank Syariah Mandiri agar memperhatikan rasio CAR, ROA dan BOPO.
EFEKTIVITAS PENERAPAN MODEL PEMBELAJARAN KOOPERATIF TIPE STAD (STUDENT TEAM ACHIEVMENT DIVISON) TERHADAP HASIL BELAJAR KOGNITIF PESERTA DIDIK SECARA DARING
Authors: Murtihapsari Murtihapsari , Patandean Sri Neni , Surbakti Putri Sarera , Larasati Christiana Niken , Toding Manuella Tandi 
Published: January 2022

Pembelajaran daring yang efektif dapat dilakukan melalui penerapan model yang tepat dan sangat tergantung dengan lingkungan belajar. Salah satu model pembelajaran dapat digunakan model kooperatif tipe STAD (Student Team Achievment Division) yang dilakukan secara daring di masa pandemi COVID-19. Tujuan penelitian ini antara lain untuk mengetahui adanya pengaruh, perbedaan hasil belajar kognitif dari uji T, efektivitas pembelajaran kooperatif tipe STAD (Student Team Achievment Division) terhadap hasil belajar kognitif yang dilaksanakan secara daring menggunakanN-gain dan analisis angket untuk mengetahui efektivitas melalui jawaban responden. Metode penelitian yang digunakan pre-experimental design dimana desain penelitiannya yaitu one group pretest-posttest design. Penelitian ini tidak dapat dipilih secara random. Desain penelitian ini hanya menggunakan satu kelompok saja yaitu kelompok eksperimen dan sampel yang digunakan sejumlah 46 (empat puluh enam) yaitu kelas X IPA 1. Alat pengumpulan data adalah observasi, wawancara, dan angket melalui google form. Hasil penelitian ini ditunjukkan adanya pengaruh sebesar 55%, untuk uji T mempunyai nilai sig.(2-tailed) sebesar 0,00 jadi H1 diterimadan H0 ditolak sehingga terdapat perbedaan yang signifikan dalam penggunaan model pembelajaran koopetatif tipe STAD (Student Team Achievment Division) terhadap hasil belajar kognitif peserta didik pada materi reaksi redoks, adanya peningkatan hasil belajar dengan tafsiran efektivitas N-gain sebesar 60% termasuk dalam kategori cukup efektif dananalisisangket untuk jawaban responden masuk kategori cukup baik
Research on the Water Production Tracking Method of Horizontal Well in Heavy Oil Reservoir with Bottom Water
Authors: Yue Pan , Kai Wang , Chenyang Tang , Ke Li , He Liu 
Published: January 2022

Abstract
At present, the model of heterogeneous fluid production in horizontal wells in bottom water reservoirs does not comprehensively consider the influence of parameters such as flow, length, and position of each production section, resulting in the distortion of interpretation results. Using the Green function and the Newman product method, this paper derives heterogeneous fluid production in horizontal wells in the bottom water heavy oil reservoir. The Stehfest numerical inversion algorithm was used to obtain the bottom fluid pressure solution of the horizontal well production in the bottom water heavy oil reservoir with the wellbore storage effect and skin effect. By drawing the typical chart of horizontal well test in sections, the new model can be divided into five typical flow stages: wellbore storage stage, transition stage, radial flow stage, linear flow stage, and late stable flow stage. Based on the interpretation of conventional parameters, such as permeability, well storage, and skin effect, the new model can further diagnose the parameters such as liquid production length, liquid production position, and liquid production volume of each horizontal section. The field application examples verify the validity of the research results and broad application prospects.