bluuebunny/crossref_metadata_2025_split huggingface dataset:
Recent progress in the development of smart supercapacitors
Authors: Xiong Chuanyin , Wang Tianxu , Zhao Zhenyang , Ni Yonghao 
Published: November 2022

AbstractRecently, with the continuous development of human society and the continuous innovation of technologies, the intelligence era has arrived. Various intelligent electronic devices continue to be developed, in which flexible wearable electronic devices are highly favored by people. To meet the requirements of the normal operation of intelligent devices, the key point lies in the development of new smart energy storage devices. Accordingly, smart supercapacitors have been widely focused on and studied by researchers recently with the introduction of intelligent functions, such as electrochromism, self‐healing, and shape memory, into supercapacitors to broaden their application fields and promote their smart development. This can meet not only people's energy needs but also people's diverse personality needs and make our life more convenient, fast, and more intelligent than ever. Therefore, it is very important to summarize related work on smart supercapacitors. Although researchers have performed much research on smart supercapacitors, there is still little literature summary on the related work of different smart supercapacitors. Accordingly, this paper mainly introduces the research progress on electrochromic, self‐healing, shape memory, and self‐charging smart supercapacitors in recent years and discusses the development prospects and challenges of smart supercapacitors.
Adopting microservices and DevOps in the cyber‐physical systems domain: A rapid review and case study
Authors: Fritzsch Jonas , Bogner Justus , Haug Markus , Franco da Silva Ana Cristina , Rubner Carolin , Saft Matthias , Sauer Horst , Wagner Stefan 
Published: November 2022

AbstractThe domain of cyber‐physical systems (CPS) has recently seen strong growth, for example, due to the rise of the Internet of Things (IoT) in industrial domains, commonly referred to as “Industry 4.0.” However, CPS challenges like the strong hardware focus can impact modern software development practices, especially in the context of modernizing legacy systems. While microservices and DevOps have been widely studied for enterprise applications, there is insufficient coverage for the CPS domain. Our goal is therefore to analyze the peculiarities of such systems regarding challenges and practices for using and migrating towards microservices and DevOps. We conducted a rapid review based on 146 scientific papers, and subsequently validated our findings in an interview‐based case study with nine CPS professionals in different business units at Siemens AG. The combined results picture the specifics of microservices and DevOps in the CPS domain. While several differences were revealed that may require adapted methods, many challenges and practices are shared with typical enterprise applications. Our study supports CPS researchers and practitioners with a summary of challenges, practices to address them, and research opportunities.
OS‐in‐the‐Loop verification for multi‐tasking control software
Authors: Choi Yunja 
Published: November 2022

SummaryEmbedded control software that controls safety‐critical IoT devices requires systematic and comprehensive verification to ensure safe operation of the device. However, rigorous verification in this domain has not been feasible due to the high complexity of embedded control software, which is characterized by the frequent use of multi‐tasking, interrupts, and periodic alarms. Realizing that two major factors, scalability and exactness, are extremely difficult to achieve at the same time but critical for effective and efficient verification in this domain, this work introduces a domain‐specific compositional OS‐in‐the‐Loop (OiL) verification approach and sets out to push the boundary in achieving both factors. The suggested approach (1) models the behavior of the underlying operating system to limit the search space using the notion of controlled concurrency, (2) performs heterogeneous composition of controllers with the formal OS model to reduce verification complexity, and (3) utilizes state‐of‐the‐art verification techniques for the purpose of comprehensive verification up to a given search depth.
Nano‐α‐Fe2O3 for enhanced denitrification in a heterotrophic/biofilm‐electrode autotrophic denitrification reactor
Authors: Yin Haoran , Lin Xiangyu , Zhao Fan , Pu Yu , Chen Yini , Tang Xinhua 
Published: November 2022

AbstractIn this study, a heterotrophic/biofilm‐electrode autotrophic denitrification reactor (HAD‐BER) was constructed and nano‐ɑ‐Fe2O3 was coated on granular activated carbon (GAC) as a third electrode to enhance the nitrate removal performance. The introduction of nano‐ɑ‐Fe2O3 could stimulate microorganisms to secrete more extracellular polymeric substances (EPS), accelerating the electron transfer. Moreover, more denitrification bacteria were enriched on the particle electrodes, especially Pseudomonas and Thermomonas, which played a significant role in denitrification. The denitrification performance at different COD/N ratios (0.65–3.23) and current intensities (0–150 mA) was investigated in depth. When the nitrate concentration of the influent was 60 mg/L, nitrate was almost completely removed at the optimal current intensity (60 mA) and COD/N ratio (1.29). At the same time, there was almost no nitrite (<0.10 mg/L) and ammonia nitrogen (0 mg/L) accumulation in the effluent. This study provided a new direction for the advancement of HAD‐BER and accelerated its implementation.Practitioner Points

By introducing nano‐a‐Fe2O3 into HAD‐BER, more denitrification bacteria were enriched on the particle electrodes.
The increased contents of polysaccharide and protein content could accelerate the electron transfer.
Almost completely denitrification could be achieved at current = 60 mA and COD/N = 1.29.
The study provided a new direction for the further development of HAD‐BERs.
Assessment of idiopathic inflammatory myopathy using a deep learning method for muscle T2 mapping segmentation
Authors: Wang Fengdan , Zhou Shuang , Hou Bo , Santini Francesco , Yuan Ling , Guo Ye , Zhu Jinxia , Hilbert Tom , Kober Tobias , Zhang Yan , Wang Qian , Zhao Yan , Jin Zhengyu 
Published: November 2022

Abstract
Objective
To investigate the utility of an automatic deep learning (DL) method for segmentation of T2 maps in patients with idiopathic inflammatory myopathy (IIM) against healthy controls, and also the association of quantitative T2 values in patients with laboratory and pulmonary findings.

Methods
Structural MRI and T2 mapping of bilateral thigh muscles from patients with IIM and healthy volunteers were segmented using dedicated software based on a pre-trained convolutional neural network. Incremental and federated learning were implemented for continuous adaptation and improvement. Muscle T2 values derived from DL segmentation were compared between patients and healthy controls, and T2 values of patients were further analyzed with serum muscle enzymes, and interstitial lung disease (ILD) which was diagnosed and graded based on chest HRCT.

Results
Overall, 64 patients (27 patients with dermatomyositis, 29 with polymyositis, and 8 with antisynthetase syndrome (ASS)) and 10 healthy controls were included. By using DL-based muscle segmentation, T2 values generated from T2 maps accurately differentiated patients from those of controls (p < 0.001) with a cutoff value of 36.4 ms (sensitivity 96.9%, and specificity 100%). In patients with IIM, muscle T2 values positively correlated with all the serum muscle enzymes (all p < 0.05). ILD score of patients with ASS was markedly higher than that of those without ASS (p = 0.011), while dissociation between the severity of muscular involvement and ILD was observed (p = 0.080).

Conclusion
Automatic DL could be used to segment thigh muscles and help quantitatively assess muscular inflammation of IIM through T2 mapping.

Key Points
• Muscle T2 mapping automatically segmented by deep learning can differentiate IIM from healthy controls.
• T2 value, an indicator of active muscle inflammation, positively correlates with serum muscle enzymes.
• T2 mapping can detect muscle disease in patients with normal muscle enzyme levels.
Laparoscopic Roux-en-Y feeding jejunostomy as a long-term solution for severe feeding problems in children
Authors: van Braak H. , Gorter R. R. , van Wijk M. P. , de Jong J. R. 
Published: November 2022

AbstractEnteral feeding is a common problem in children with gastric emptying disorders. Traditional feeding methods in these patients often show a high rate of complications and maintenance issues. Laparoscopic Roux-en-Y feeding jejunostomy (LRFJ) has been described in a few patients as a minimal invasive option for enteral access in these children. The aim of this study is to evaluate the outcomes of the LRFJ procedure in our tertiary referral center. We conducted a retrospective case-series including all patients, aged 0–18 years old, that underwent a LFRJ procedure between August 2011 and December 2020 for the indication of oral feeding intolerance due to delayed gastric emptying. Outcomes evaluated were complications (short and long term) and parenteral satisfaction. In total, 12 children were identified that underwent LRFJ for the indication of oral feeding intolerance due to delayed gastric emptying. A total of 16 complications were noted in 8/12 patients (67%). Severity classified by Clavien-Dindo were grade I (n = 13), grade II (n = 1), and grade IIIB (n = 2). In 11/12 patients, parents were satisfied with the results. Conclusions: Although minor complications after LRFJ are common in our patients, this technique is a safe solution in patients with gastric emptying disorders leading to a definitive method of enteral feeding and high parenteral satisfaction.

What is Known:• Traditional tube feeding in children (duodenal, PEG-J-tubes) with severe delayed gastric emptying can be challenging with a high rate of complications and maintenance issues.• Open loop jejunostomy and Roux-en-Y jejunostomy are alternative, permanent methods of feeding but either invasive or are accompanied by severe complications. Little is known in the literature about laparoscopic Roux-en-Y feeding jejunostomy.

What is New:• Laparoscopic Roux-en-Y feeding jejunostomy is a permanent, safe and minimal invasive alternative option for enteral feeding in children with severe delayed gastric emptying..
Critical Aspects Concerning Large-scale Production of a Batch-annealed Medium-Mn 780 MPa Grade for Automotive Applications
Authors: Steineder K. , Krizan D. , Stadler M. , Ritsche S. , Berger E. , Holtmann N. , Schnitzer R. , Schneider R. 
Published: November 2022

AbstractThis article presents the results of the development of a medium-Mn780 grade at large scale production via conventional LD-converter route at the voestalpine steel plant in Linz. It highlights the property profile of the newly developed grade—being a well-balanced global-formability type for demanding deep drawing operations and crash applications. Furthermore, it offers the possibility of weight reduction by replacing grades with lower strength levels.The article highlights critical aspects of the application of the material that had to be overcome. The first aspect addresses the often-observed presence of extensive yield point elongation (YPE) in medium-Mn steels. This contribution clearly shows that YPE can be avoided by a two-step heat treatment. The second aspect concerns the robustness of the manufacturing process and refers to the sensitivity of mechanical properties to the intercritical annealing temperature, which is a concern for industrial scale production. Based on the large-scale material, this contribution can emphasize that, with a precise temperature control during a batch annealing cycle, stable mechanical properties throughout an entire coil can be achieved. The third aspect addresses the necessary suitability of the material for the resistance spot welding process. In our first investigations, the material revealed rather low cross tension strength (CTS) after welding with standard parameters. Therefore, the chemical composition was adjusted and a double-pulse regime was established to vastly increase CTS.Considering all the above-mentioned aspects, this contribution represents a compilation of critical points and possible solutions towards the large-scale implementation and subsequent use of the present material by the automotive industry.
RaQuN: a generic and scalable n-way model matching algorithm
Authors: Schultheiß Alexander , Bittner Paul Maximilian , Boll Alexander , Grunske Lars , Thüm Thomas , Kehrer Timo 
Published: November 2022

AbstractModel matching algorithms are used to identify common elements in input models, which is a fundamental precondition for many software engineering tasks, such as merging software variants or views. If there are multiple input models, an n-way matching algorithm that simultaneously processes all models typically produces better results than the sequential application of two-way matching algorithms. However, existing algorithms for n-way matching do not scale well, as the computational effort grows fast in the number of models and their size. We propose a scalable n-way model matching algorithm, which uses multi-dimensional search trees for efficiently finding suitable match candidates through range queries. We implemented our generic algorithm named RaQuN (Range Queries on $$\text {N}$$
N
input models) in Java and empirically evaluate the matching quality and runtime performance on several datasets of different origins and model types. Compared to the state of the art, our experimental results show a performance improvement by an order of magnitude, while delivering matching results of better quality.
Minimizing patients total clinical condition deterioration in operating theatre departments
Authors: Mashkani Omolbanin , Ernst Andreas T. , Thiruvady Dhananjay , Gu Hanyu 
Published: November 2022

AbstractThe operating theatre is the most crucial and costly department in a hospital due to its expensive resources and high patient admission rate. Efficiently allocating operating theatre resources to patients provides hospital management with better utilization and patient flow. In this paper, we tackle both tactical and operational planning over short-term to medium-term horizons. The main goal is to determine an allocation of blocks of time on each day to surgical specialties while also assigning each patient a day and an operating room for surgery. To create a balance between improving patients welfare and satisfying the expectations of hospital administrators, we propose six novel deterioration rates to evaluate patients total clinical condition deterioration. Each deterioration rate is defined as a function of the clinical priorities of patients, their waiting times, and their due dates. To optimize the objective functions, we present mixed integer programming (MIP) models and two dynamic programming based heuristics. Computational experiments have been conducted on a novel well-designed and carefully chosen benchmark dataset, which simulates realistic-sized instances. The results demonstrate the capability of the MIP models in finding excellent solutions (maximum average gap of 4.71% across all instances and objective functions), though, requiring large run-times. The heuristic algorithms provide a time-efficient alternative, where high quality solutions can be found in under a minute. We also analyse each objective function’s ability in generating high quality solutions from different perspectives such as patients waiting times, the number of scheduled patients, and operating rooms utilization rates. We provide managerial insights to the decision makers in cases where their intention is to meet KPIs and/or maintaining trade-offs between patients and administrators expectations, more fair assignments, or ensuring that the most urgent patients are taken care of first.
LES and PIV Investigation of the Flow Past a Cactus-Shaped Cylinder with Four Ribs
Authors: Zhdanov Oleksandr , Green Richard , Busse Angela 
Published: November 2022

AbstractThe flow past a cactus-shaped cylinder with four ribs is investigated numerically using large eddy simulations (LES) at Reynolds number of 20,000 and experimentally using particle image velocimetry (PIV) at Reynolds number of 50,000. In both approaches, the full range of angle of attack is covered. LES results show a good qualitative and quantitative match of the aerodynamic properties to previous experimental data, although the value of the critical angle of attack is slightly lower. The results confirm that there is no Reynolds number dependency within the investigated range allowing a comparison of the flow fields from the present LES and PIV. Significant variations of the flow patterns with the angle of attack are found and quantified using the recirculation length and wake width. Overall, the observed angle of attack dependence resembles the behaviour of the square cylinder. However, the studied cylinder has a narrower wake at all angular orientations. Proper orthogonal decomposition is used to identify large coherent structures in the flow. At all angles of attack the first two modes remain dominant making it possible to reconstruct the periodic vortex shedding process using a low-order model.
The Intransparency of Parentheticalism
Authors: Freitag Wolfgang 
Published: November 2022

AbstractIt has frequently been observed that typical utterances of the form “I believe that P” are assertions of the embedded proposition P. Yet that the matrix clause “I believe that” should be semantically idle creates an interesting puzzle: linguistic orthodoxy holds that the utterance is an assertion about one’s doxastic state, not about the content of this state. In response to the puzzle, Tim Henning has recently proposed a new semantic theory, parentheticalism, according to which “S believes that P” expresses P from S’s point of view: the at-issue content in belief ascriptions is the embedded proposition P. The puzzle is then claimed to be resolved as follows: as speaker and doxastic subject are identical in the first-person case, “I believe that P” expresses P from the speaker’s own point of view. In this paper, I argue, first, that parentheticalism is highly doubtful and, second, that even if parentheticalism were true, it would be unable to resolve the transparency puzzle.
Pure shift amide detection in conventional and TROSY-type experiments of 13C,15N-labeled proteins
Authors: Haller Jens D. , Bodor Andrea , Luy Burkhard 
Published: November 2022

AbstractLarge coupling networks in uniformly 13C,15N-labeled biomolecules induce broad multiplets that even in flexible proteins are frequently not recognized as such. The reason is that given multiplets typically consist of a large number of individual resonances that result in a single broad line, in which individual components are no longer resolved. We here introduce a real-time pure shift acquisition scheme for the detection of amide protons which is based on 13C-BIRDr,X. As a result the full homo- and heteronuclear coupling network can be suppressed at low power leading to real singlets at substantially improved resolution and uncompromised sensitivity. The method is tested on a small globular and an intrinsically disordered protein (IDP) where the average spectral resolution is increased by a factor of ~ 2 and higher. Equally important, the approach works without saturation of water magnetization for solvent suppression and exchanging amide protons are not affected by saturation transfer.
Fast and slow skeletal myosin binding protein-C and aging
Authors: Perazza L. R. , Wei G. , Thompson L. V. 
Published: November 2022

AbstractAging is associated with skeletal muscle strength decline and cardiac diastolic dysfunction. The structural arrangements of the sarcomeric proteins, such as myosin binding protein-C (MyBP-C) are shown to be pivotal in the pathogenesis of diastolic dysfunction. Yet, the role of fast (fMyBP-C) and slow (sMyBP-C) skeletal muscle MyBP-C remains to be elucidated. Herein, we aimed to characterize MyBP-C and its paralogs in the fast tibialis anterior (TA) muscle from adult and old mice. Immunoreactivity preparations showed that the relative abundance of the fMyBP-C paralog was greater in the TA of both adult and old, but no differences were noted between groups. We further found that the expression level of cardiac myosin binding protein-C (cMyBP-C), an important modulator of cardiac output, was lowered by age. Standard SDS-PAGE along with Pro-Q Diamond phosphoprotein staining did not identify age-related changes in phosphorylated MyBP-C proteins from TA and cardiac muscles; however, it revealed that MyBP-C paralogs in fast skeletal and cardiac muscle were highly phosphorylated. Mass spectrometry further identified glycogen phosphorylase, desmin, actin, troponin T, and myosin regulatory light chain 2 as phosphorylated myofilament proteins in both ages. MyBP-C protein-bound carbonyls were determined using anti-DNP immunostaining and found the carbonyl level of fMyBP-C, sMyBP-C, and cMyBP-C to be similar between old and adult animals. In summary, our data showed some differences regarding the MyBP-C paralog expression and identified an age-related reduction of cMyBP-C expression. Future studies are needed to elucidate which are the age-driven post-translational modifications in the MyBP-C paralogs.
Rapamycin not dietary restriction improves resilience against pathogens: a meta-analysis
Authors: Phillips Eleanor J. , Simons Mirre J. P. 
Published: November 2022

Abstract Dietary restriction (DR) and rapamycin both increase lifespan across a number of taxa. Despite this positive effect on lifespan and other aspects of health, reductions in some physiological functions have been reported for DR, and rapamycin has been used as an immunosuppressant. Perhaps surprisingly, both interventions have been suggested to improve immune function and delay immunosenescence. The immune system is complex and consists of many components. Therefore, arguably, the most holistic measurement of immune function is survival from an acute pathogenic infection. We reanalysed published post-infection short-term survival data of mice (n = 1223 from 23 studies comprising 46 effect sizes involving DR (n = 17) and rapamycin treatment (n = 29) and analysed these results using meta-analysis. Rapamycin treatment significantly increased post infection survival rate (lnHR =  − 0.72; CI =  − 1.17, -0.28; p = 0.0015). In contrast, DR reduced post-infection survival (lnHR = 0.80; CI = 0.08, 1.52; p = 0.03). Importantly, the overall effect size of rapamycin treatment was significantly lower (p < 0.001) than the estimate from DR studies, suggesting opposite effects on immune function. Our results show that immunomodulation caused by rapamycin treatment is beneficial to the survival from acute infection. For DR, our results are based on a smaller number of studies, but do warrant caution as they indicate possible immune costs of DR. Our quantitative synthesis suggests that the geroprotective effects of rapamycin extend to the immune system and warrants further clinical trials of rapamycin to boost immunity in humans.