bluuebunny/crossref_metadata_2025_split huggingface dataset:
Interdependent functions of communication with adolescents and young adults in oncology
Authors: Sisk Bryan A. , Keenan Megan , Schulz Ginny L. , Kaye Erica , Baker Justin N. , Mack Jennifer W. , DuBois James M. 
Published: January 2022

AbstractBackgroundCommunication is central to patient‐centered care in adolescent and young adult (AYA) cancer. Previously, we developed a functional communication model from perspectives of parents whose children had cancer. No prior studies have established a framework for the breadth of communication functions in AYA oncology. We aimed to identify these communication functions from AYAs’ perspectives.MethodsSemistructured interviews with 37 AYAs with cancer aged 12–24 years at diagnosis from two pediatric centers during treatment or survivorship. We performed thematic analysis, using a functional communication model as an a priori framework, but remaining open to novel themes.ResultsWe identified eight interdependent functions of communication in AYA oncology that were consistent with those previously identified among parents: building relationships, exchanging information, enabling family self‐management, making decisions, managing uncertainty, responding to emotions, providing validation, and supporting hope. AYAs held varying preferences for engagement in different communication functions. While some AYAs preferred very passive or active roles, most AYAs described an interdependent process of communication involving them, their parents, and their clinicians. Parents often served as a conduit and buffer of communication between the AYA and clinician.ConclusionsInterviews with AYAs provided evidence for eight interdependent communication functions in AYA oncology. Many AYAs described the integral role of parents in communication regardless of their age. Clinicians can use this framework to better understand and fulfill the communication needs of AYA patients. Future work should aim to measure and intervene upon these functions to improve communication experiences for AYAs with cancer.
Palladium‐immobilized polymer‐coated magnetic nanocomposites as reusable catalysts for the reduction of 4‐nitrophenol
Authors: Mahanitipong Usana , Rutnakornpituk Metha 
Published: January 2022

AbstractPalladium‐immobilized polymer‐coated magnetic nanoparticles (MNP@polymer‐Pd) were successfully synthesized for use as reusable catalysts for the reduction of 4‐nitrophenol (4NP) in water. The homopolymers and copolymers (e.g. poly(poly(ethylene glycol) methacrylate), PPEGMA; poly(2‐dimethylamino)ethyl methacrylate, PDMAEMA; and poly(2‐diethylamino)ethyl methacrylate, PDEAEMA) were well designed to chemically graft on the surface of the magnetite nanoparticles (MNPs) with the rationalization that PPEGMA improved their water dispersibility and the amino‐containing polymers, e.g. PDMAEMA and PDEAEMA, enhanced the coordinating interaction with Pd and essentially improved their recycling efficiency. The presence of Pd and Fe in the nanocomposites was confirmed via energy‐dispersive X‐ray spectroscopy. The nanocomposites possessed Pd loadings ranging between 0.7006 and 0.8442 mmol g–1. The nanocomposites containing PDMAEMA or PDEAEMA showed higher immobilization efficiency of Pd on their surface than those without these amino‐containing polymers. Interestingly, the nanocomposites having PDEAEMA exhibited an improved catalytic activity for the 4NP reduction compared to those having PDMAEMA. They displayed sustainable reusability for the 4NP reduction after eight cycles without a significant loss in their catalytic performance (99% conversion). © 2022 Society of Industrial Chemistry.
Changes over 6 years in secondary health conditions and activity limitations in older adults aging with long‐term spinal cord injury
Authors: Waller Mikael , Jörgensen Sophie , Lexell Jan 
Published: January 2022

AbstractBackgroundThe number of individuals aging with long‐term spinal cord injury (SCI) is increasing. Still, there is limited knowledge about changes in secondary health conditions (SHCs) and activity limitations over time.ObjectivesTo determine changes in SHCs and activity limitations in older adults aging with long‐term SCI over 6 years, and to investigate how changes in SHCs and activity limitations are associated with gender, age, and injury characteristics.DesignLongitudinal cohort study from the Swedish Aging with Spinal Cord Injury Study (SASCIS).SettingCommunity settings, Sweden.ParticipantsFrom the initial 123 participants in the SASCIS: 78 individuals (32% women); mean age 68 years; mean time since injury 31 years; injury levels C1‐L3, AIS A‐D.InterventionsNot applicableMain Outcome MeasureBowel and bladder function and problems, pain, spasticity, and the Spinal Cord Independence Measure (SCIM III).ResultsOver 6 years, bowel‐related problems increased (31% to 47%, p = .015) and the occurrence of constipation doubled to 24% (p = .013). There were increases in frequent urinary tract infections (10% to 26%, p = .004), use of indwelling urinary catheters (15% to 23%, p = .031), and other bladder‐related problems (4% to 22%, p < .001). The occurrence of pain was high (85%), with no significant change. Spasticity increased from 41% to 62% (p < .001). Activity limitations increased (SCIM III total score mean 67 to 61, p < .001, with significant decreases in all subscales). The increase in bowel‐related problems was greater in males, and the deterioration in self‐care was greater in participants with longer time since injury and with traumatic injuries.ConclusionsThese findings support the notion that SHCs and activity limitations increase over time in older adults aging with long‐term SCI. The results can inform clinicians and call for a proactive, holistic approach in the long‐term follow‐up to support healthy and active aging.
Microfluidic fabrication of β‐phase enriched poly(vinylidene fluoride) microfibers toward flexible piezoelectric sensor
Authors: Meng Xiangyi , Li Qingqing , Hu Zhijun , Guo Mingyu 
Published: January 2022

Abstractβ‐phase enriched piezoelectric poly(vinylidene fluoride) (PVDF) films/fibers are often prepared by high‐energy costing methods, including mechanical stretching, high‐electric field or electrospinning. In this study, PVDF piezoelectric microfibers, for the first time, were prepared by microfluidic spinning technology. The β‐phase enriched PVDF microfibers with various diameters could be easily obtained inside the microfluidic channel due to the mass transfer induced phase inversion of the inner PVDF solution. The influence of diameter of the fibers, PVDF concentration of the inner phase and water content of the outer phase on the β‐phase content and crystallinity degree of the obtained fibers was studied in detail. The obtained β‐phase enriched fiber was weaved into meshes. Flexible piezoelectric fabrics were then developed based on these meshes, and further used as in‐situ and real time human motion monitoring. This simple and effective strategy provides a promising microfluidic spinning technique toward the development of functional microfibers and wearable piezoelectric sensors, which may also give some implies for the industrial wet‐spinning of piezoelectric PVDF fibers in the future.
Deflagration to Detonation Transition in Cast Explosives: Revisiting the Classical Model
Authors: Gupta Rishi , Kumar Mayank , Singh Santosh Kumar , Singla Gulshan Kumar , Narang Rajiv 
Published: January 2022

AbstractUnderstanding the deflagration to detonation transition (DDT) in solid explosives is important from the viewpoint of safety, especially in situations where detonation is undesirable. Relevant examples include the storage or safe disposal of life‐expired or unserviceable explosives and ammunition. The present work proposes improvements on the existing mathematical models for predicting DDT in cast explosives. The earlier classic studies on this topic utilized the isothermal Modified Tait EOS for modelling the compression of the unreacted explosive and incorporated the experimentally measured pressure rise profile in their DDT calculations. This work implements various isentropic EOS, such as the Hugoniot EOS and the Walsh mirror image approximation EOS, to model the compression of the solid explosive. Moreover, since measured pressure rise profiles are available in the literature for a very limited set of explosives and operating conditions, a generalized mathematical model for the pressure rise of the burnt gas under various clearance volumes is proposed in this work. The pressure‐rise model matches the reported profiles reasonably well for Pentolite 50/50 and diethylnitramine dinitrate (DINA). The integrated model indicates that the combination of Hugoniot EOS and Adams & Pack DDT model provides the most conservative estimate for the run‐up distance to DDT among the alternatives considered. We also report that the run‐up distance to detonation depends linearly on the initial clearance volume provided to the cast explosive.
Quantitative analysis of wall thinning of bimetallic clad steel tube based on pulsed eddy current
Authors: Xiong Jingyi , Liang Wei , Ding Yu , Yao Junming 
Published: January 2022

AbstractBimetallic clad steel tube (BCST) has been widely adopted in onshore and offshore oil and gas transportation due to its excellent corrosion resistance and mechanical properties. Aged BCSTs are susceptible to the initiation of various types of defects, including corrosion, dents, cracking/leakage, and wall‐thinning defects. However, due to the complex structure of BCST and the different materials of inner and outer tubes, it is difficult to implement conventional nondestructive testing. In light of this, a finite element simulation model is established based on the pulsed eddy current testing technology in this paper. Through a series of simulation analyses, the influence of tubing material, defect location, and other factors on the detection results is intensively investigated. By establishing the mapping relationship between the detection signal characteristics and the wall thickness reduction ratio, it is confirmed that there is a quadratic relationship between the differential voltage peak value and the wall thickness reduction, and the defect identification and quantitative evaluation are carried out. The validity of the proposed defect identification and quantitative evaluation method is verified by experiments, which provides a theoretical basis for BCST nondestructive testing and state maintenance. This work facilitates BCSTs structural integrity management and state maintenance decisions, which are critical to the safe operation of the oil and gas system.
Functional investigation of lncRNAs and target cytochrome P450 genes related to spirotetramat resistance in Aphis gossypii Glover
Authors: Peng Tianfei , Liu Xuemei , Tian Fayi , Xu Hongfei , Yang Fengting , Chen Xuewei , Gao Xiwu , Lv Yuntong , Li Jianyi , Pan Yiou , Shang Qingli 
Published: January 2022

AbstractBACKGROUNDSpirotetramat is a tetramic acid derivative insecticide with novel modes of action for controlling Aphis gossypii Glover in the field. Previous studies have shown that long noncoding RNAs (lncRNAs) and cytochrome P450 monooxygenases (P450s) are involved in the detoxification process. However, the functions of lncRNAs in regulating P450 gene expression in spirotetramat resistance in A. gossypii are unknown.RESULTSIn this study, we found CYP4CJ1, CYP6CY7 and CYP6CY21 expression levels to be significantly upregulated in a spirotetramat‐resistant (SR) strain compared with a susceptible (SS) strain. Furthermore, knockdown of CYP4CJ1, CYP6CY7 and CYP6CY21 increased nymph and adult mortality in the SR strain following exposure to spirotetramat. Drosophila ectopically expressing CYP380C6, CYP4CJ1, CYP6DA2, CYP6CY7 and CYP6CY21 showed significantly decreased mortality after spirotetramat exposure, and CYP380C6, CYP4CJ1 and CYP6CY21 are putative targets of six lncRNAs. Silencing of lncRNAs MSTRG.36649.2/5 and MSTRG.71880.1 changed CYP6CY21 and CYP380C6 expression, altering the sensitivity of the SR strain to spirotetramat. Moreover, MSTRG.36649.2/5 did not compete for microRNA (miRNA) binding to regulate CYP6CY21 expression.CONCLUSIONOur results confirm that CYP380C6, CYP4CJ1, CYP6DA2, CYP6CY7 and CYP6CY21 are potentially involved in the development of spirotetramat resistance in A. gossypii, and MSTRG.36649.2/5 and MSTRG.71880.1 probably regulate CYP6CY21 and CYP380C6 expression other than through the “sponge effect” of competing for miRNA binding. Our results provide a favorable molecular basis for studying cotton aphid P450 genes and lncRNA functions in spirotetramat resistance development.
The effect of both Pt decoration and the defects on the adsorption of graphene for SO2
Authors: Qu Yongfeng , Ding Jijun , Chen Haixia , Hu Wenbo , Fan Huiqing 
Published: January 2022

AbstractWe systematically investigate the combined effect of both the defects, including single vacancy defects (SV) and Stone‐Wales defects (SW), and the decoration of Pt atom on the structural, electronic, and adsorption properties of graphene for SO2 molecule using the density functional theory (DFT). The calculations reveal that Pt atom can be stably combined on both SV defected graphene (SVG) and SW defected graphene (SWG) with the high‐binding energy of −7.03 and −2.61 eV, respectively. In addition, the SO2 molecule is chemically adsorbed on Pt‐decorated graphene with SV defects and SW defects, their adsorption energies are −1.402 and −1.891 eV, respectively. The adsorption of SO2 can significantly change the conductivity of the adsorbed system, which shows that Pt decorated SVG and SWG have good sensitivity to SO2. Moreover, compared with Pt decorated SVG, Pt decorated SWG has better adsorption ability for SO2 gas molecules, which corresponds to larger adsorption energy, strong orbital hybridization, and the obvious increase of conductivity. These results indicate that the combination of defects and Pt atom decoration can tune the electronic and adsorption properties of graphene, and provide insight into the application of graphene‐based gas sensors for SO2 gas molecules.
Microbiome analysis in women with endometriosis: Does a microbiome exist in peritoneal fluid and ovarian cystic fluid?
Authors: Oishi Sugiko , Mekaru Keiko , Tanaka Suguru E. , Arai Wataru , Ashikawa Kyota , Sakuraba Yoshiyuki , Nishioka Mikiko , Nakamura Rie , Miyagi Maho , Akamine Kozue , Aoki Yoichi 
Published: January 2022

AbstractPurposeTo investigate the relationship between the microbiome of the female genital tract and endometriosis.MethodsThis prospective cohort study included 36 women who underwent laparoscopic surgery for ovarian tumor from July 2019 to April 2020. Of them, 18 had endometriosis, and 18 did not have endometriosis. Vaginal secretions, endometrial fluid, peritoneal fluid, and ovarian cystic fluid were collected during surgery. Next‐generation sequencing of bacterial 16S rRNA was performed to characterize the microbiome.ResultsSpecific microbiomes were not detected in either peritoneal fluid or ovarian cystic fluid regardless of the presence or absence of endometriosis and the type of cyst. When the cutoff value of infectious bacterial abundance in the vagina was set as 64.3%, there were many cases more than a cutoff value in the endometriosis group significantly (p = 0.01). When the cutoff value of infectious bacterial abundance in the endometrium was set as 18.6%, there were many cases more than a cutoff level in the endometriosis cases significantly (p = 0.02).ConclusionPeritoneal fluid and ovarian cystic fluid are almost sterile, although dysbiosis may occur in the vaginal and endometrial microbiome in women with endometriosis.
New-Onset Vitiligo Following COVID-19 Disease
Authors: Herzum A. , Micalizzi C. , Molle M. F. , Parodi A. 
Published: January 2022

Abstract

Background
Coronavirus disease 2019 (COVID-19) disease and vaccines have been associated to various skin reactions, which are mostly similar amongst them. New onset of vitiligo and hypopigmentations have been described following COVID-19 vaccination, but never after COVID-19 infection.

Objectives
We present the case of a 45-year-old woman, who developed vitiligo 2 weeks after COVID-19 disease. Skin lesions stabilized after 1 month of initial spreading.

Results
Vitiligo is a relatively common acquired pigmentary disorder, possibly caused by a T CD8+ cell-mediated autoimmune process, which may be enhanced after the immune activation of COVID-19 disease. Molecular mimicry and bystander activation have been advocated as possible pathogenic mechanisms of vitiligo after COVID-19 vaccination. The same mechanisms may also be involved as possible vitiligo triggers during COVID-19 disease.

Conclusions
Clinicians should be aware of this possible autoimmune cutaneous reaction to COVID-19 disease.
High‐Throughput DNA Tensioner Platform for Interrogating Mechanical Heterogeneity of Single Living Cells
Authors: Hang Xinxin , He Shiqi , Dong Zaizai , Li Yun , Huang Zheng , Zhang Yanruo , Sun Hong , Lin Long , Li Hu , Wang Yang , Liu Bing , Wu Nan , Ren Tianling , Fan Yubo , Lou Jizhong , Yang Ruiguo , Jiang Lan , Chang Lingqian 
Published: January 2022

AbstractCell mechanical forces play fundamental roles in regulating cellular responses to environmental stimulations. The shortcomings of conventional methods, including force resolution and cellular throughput, make them less accessible to mechanical heterogeneity at the single‐cell level. Here, a DNA tensioner platform is introduced with high throughput (>10 000 cells per chip) and pN‐level resolution. A microfluidic‐based cell array is trapped on “hairpin‐structured” DNA tensioners that enable transformation of the mechanical information of living cells into fluorescence signals. By using the platform, one can identify enhanced mechanical forces of drug‐resistant cells as compared to their drug‐sensitive counterparts, and mechanical differences between metastatic tumor cells in pleural effusion and nonmetastatic histiocytes. Further genetic analysis traces two genes, VEGFA and MINK1, that may play deterministic roles in regulating mechanical heterogeneities. In view of the ubiquity of cells’ mechanical forces in the extracellular microenvironment (ECM), this platform shows wide potential to establish links of cellular mechanical heterogeneity to genetic heterogeneity.
All‐Nanofiber‐Based Janus Epidermal Electrode with Directional Sweat Permeability for Artifact‐Free Biopotential Monitoring
Authors: Yang Xianqing , Wang Shuqi , Liu Mengyuan , Li Lianhui , Zhao Yangyong , Wang Yongfeng , Bai Yuanyuan , Lu Qifeng , Xiong Zuoping , Feng Simin , Zhang Ting 
Published: January 2022

AbstractEpidermal electronics have been developed with gas/sweat permeability for long‐term wearable electrophysiological monitoring. However, the state‐of‐the‐art breathable epidermal electronics ignore the sweat accumulation and immersion at the skin/device interface, resulting in serious degradation of the interfacial conformality and adhesion, leading to signal artifacts with unstable and inaccurate biopotential measurements. Here, the authors present an all‐nanofiber‐based Janus epidermal electrode endowed with directional sweat transport properties for artifact‐free biopotential monitoring. The designed Janus multilayered membrane (≈15 µm) of superhydrophilic‐hydrolyzed‐polyacrylonitrile (HPAN)/polyurethane (PU)/Ag nanowire (AgNW) can quickly (less than 5 s) drive sweat away from the skin/electrode interface while resisting its penetration in the reverse direction. Along with the medical adhesive (MA)‐reinforced junction‐nodes, the adhesion strength among the heterogeneous interfaces can be greatly enhanced for robust mechanical‐electrical stability. Therefore, their measured on‐body electromyography (EMG) and electrocardiography (ECG) signals are free of sweat artifacts with negligible degradation and baseline drift compared to commercial Ag/AgCl gel electrodes and hydrophilic textile electrodes. This work paves a way to design novel directional‐sweat‐permeable epidermal electronics that can be conformally attached under sweaty conditions for long‐term biopotential monitoring and shows the potential to apply epidermal electronics to many challenging conditions.
Biomimetic Activator of Sonodynamic Ferroptosis Amplifies Inherent Peroxidation for Improving the Treatment of Breast Cancer
Authors: Zhou Anwei , Fang Tianliang , Chen Kerong , Xu Yurui , Chen Zhuo , Ning Xinghai 
Published: January 2022

AbstractFerroptosis is a type of nonapoptotic cell death and is gradually emerging as an important anticancer treatment. However, its therapeutic efficacy is impaired by low intracellular levels of reactive oxygen species (ROS) and long‐chain polyunsaturated fatty acids, significantly limiting its therapeutic potential. Herein, a multimodal strategy to improve ferroptosis is presented, in which a state‐of‐art engineered erythrocyte, termed as sonodynamic amplified ferroptosis erythrocyte (SAFE), is developed for simultaneously activating ferroptosis and oxygen‐riched sonodynamic therapy (SDT). SAFE is composed of internalizing RGD peptide and red blood cell membrane hybrid camouflaged nanocomplex of hemoglobin, perfluorocarbon, ferroptosis activator (dihomo‐γ‐linolenic acid, DGLA), and sonosensitizer verteporfin. It is identified that SAFE, under ultrasound stimulation, can not only substantially supply oxygen to overcome tumor hypoxia associated therapeutic resistance, but effectively activate ferroptosis through the coeffect of SDT triggered ROS production and DGLA mediated lipid peroxidation. In vivo studies reveal that SAFE selectively accumulates in tumor tissues and induces desirable anticancer effects under mild ultrasound stimulation. Importantly, SAFE can effectively inhibit tumor growth with minimal invasiveness, resulting in a prolonged survival period of mice. Therefore, a multimodal ferroptosis therapy driven by oxygen‐riched sonodynamic peroxidation of lipids, significantly advancing synergistic cancer treatment, is presented.
Eight‐Component Nanoporous High‐Entropy Oxides with Low Ru Contents as High‐Performance Bifunctional Catalysts in Zn‐Air Batteries
Authors: Jin Zeyu , Lyu Juan , Hu Kailong , Chen Zuhuang , Xie Guoqiang , Liu Xingjun , Lin Xi , Qiu Hua‐Jun 
Published: January 2022

AbstractOne major challenge in heterogeneous catalysis is to reduce the usage of noble metals while maintaining the overall catalytic stability and efficiency in various chemical environments. In this work, a series of high‐entropy catalysts are synthesized by a chemical dealloying method and find the increased entropy effect and non‐noble metal contents would facilitate the formation of complete oxides with low crystallinity. Importantly, an optimal eight‐component high‐entropy oxide (HEO, Al‐Ni‐Co‐Ru‐Mo‐Cr‐Fe‐Ti) is identified, which exhibits further enhanced catalytic activity for the oxygen evolution reaction (OER) as compared to the previously reported quinary AlNiCoRuMo and the widely‐used commercial RuO2 catalysts, and at the same time similar catalytic activity for the oxygen reduction reaction (ORR) as the commercial Pt/C with a half‐wave potential of 0.87 V. Such high‐performance bi‐functional catalysts, however, only require a half loading amount of Ru as compared to the quinary AlNiCoRuMo, due to the underlying Cr‐Fe synergistic effects on tuning the electronic structures at active surface sites, as revealed by the first‐principles density functional theory calculations of the authors. The eight‐component HEO also demonstrates excellent stability under continuous electrochemical working conditions, suitable for a wide range of applications such as metal‐air batteries.