bluuebunny/crossref_metadata_2025_split huggingface dataset:
Translation and Cross-cultural Adaptation of the Self-care of Hypertension Inventory for Thais With Hypertension
Authors: Phonphet Chennet , Suwanno Jom , Thiamwong Ladda , Mayurapak Chidchanok , Ninla-aesong Putrada 
Published: January 2022

Background
Self-care is essential for treating hypertension by lowering and controlling blood pressure, to ultimately reduce cardiovascular disease. A valid and reliable hypertension self-care measure is needed for the Thai population.

Objective
The aim of this study was to translate a cross-cultural adaptation of the Self-care of Hypertension Inventory (SC-HI) into Thai and conduct a pretest of the Thai SC-HI (version 2.0).

Methods
We performed a methodological study. The stepped approach included translation of the original version of the SC-HI into Thai (forward), synthesis of translation, translation of the Thai version back to English, expert committee review, and pretesting. Pretest phase for feasibility, interobserver agreement, and temporal stability tests were performed in 140 patients with hypertension.

Results
Translation equivalence was obtained between the Thai and the original US versions. The item-level content validity index was rated by 9 experts; the relevance, clarity, simplicity, and ambiguity criteria were all 1.00. Similarly, the scale-level content validity indices were 1.00 for the overall instrument and the self-care maintenance, self-care management, and self-care confidence scales. The item-level intraclass correlation coefficients (ICCs) had a range of 0.97 to 1.00 for interobserver agreement and 0.95 to 1.00 for test-retest, respectively. The interobserver ICCs were 0.99 for the total scale and 3 separate scales. The test-retest ICCs were 0.99 for the total scale, with a range of 0.97 to 0.99 for the three separate scales.

Conclusion
The process of cross-cultural adaptation warranted validity and reliability testing of the Thai SC-HI. Psychometric testing of this instrument is needed for evaluation in a large sample of individuals with hypertension.
Surgical Treatment for Pneumothorax and Tumor-bronchial Fistula Secondary to Pulmonary Metastasis of Osteosarcoma in Pediatric and Adolescent Patients
Authors: Kawakubo Naonori , Hishiki Tomoro , Arakawa Ayumu , Nakajima Miho , Kumamoto Tadashi , Nakagawa Kazuo , Kawai Akira , Ogawa Chitose 
Published: January 2022

Background:
Pneumothorax and tumor-bronchial fistula are rare complications of pulmonary metastasis of osteosarcoma.

Observations:
We herein report the cases of 3 pediatric and adolescent patients who developed pneumothorax or tumor-bronchial fistula during treatment of pulmonary metastasis of osteosarcoma with chemotherapeutics or antiangiogenic agents. Two patients developed pneumothorax, and the other patient developed tumor-bronchial fistula. All of the patients finally underwent the surgery to treat their complications.

Conclusions:
Although it is not a curative surgery, surgery for pneumothorax and tumor-bronchial fistula is acceptable. The operative procedure should be considered on the basis of the predicted prognosis of the patient.
Perinatal Care of Childhood Sexual Abuse Survivors
Authors: Head Morgan L. , Heck Jennifer L. 
Published: January 2022

Abstract

Background:
An estimated one in nine women seeking perinatal care is a survivor of childhood sexual abuse (CSA), yet CSA may be unknown to nurses and other health care providers. Childhood sexual abuse can have adverse physical and psychological effects for survivors, and the intimacy of perinatal care can trigger distress like intrusive thoughts.

Purpose:
To explore available literature about CSA survivors and perinatal care. Specific aims were to 1) identify nursing actions that ease undesirable feelings during perinatal care for CSA survivors and 2) identify gaps in the literature on perinatal care for CSA survivors.

Study Design and Methods:
Following the PRISMA-ScR Checklist, MEDLINE and CINAHL databases were searched using: “Child Abuse, Sexual,” “Perinatal Care,” and “Parturition.” Initial yield was 109 records.

Results:
Applying inclusion and exclusion criteria produced 14 full-text articles. Findings suggest that obtaining consent, promoting safety, trust, and control, fostering a healthy nurse–patient relationship, and inquiring about abuse may improve how CSA survivors experience perinatal care. Gaps in literature include nursing assessments for history of CSA with nonverbal cues.

Clinical Implications:
For all patients, nurses should foster security and trust. It is critical that CSA survivors be in control of their care. Procedures should be thoroughly explained, and most importantly, consent should be obtained prior to every physical touch. Nurses must ask about history of CSA because it is part of patient-centered care, which is central to nursing.
Prevalence of Burnout Among Cardiothoracic Radiologists
Authors: Eisenberg Ronald L. , Sotman Timothy E. , Czum Julianna M. , Montner Steven M. , Meyer Cristopher A. 
Published: January 2022

Purpose:
We investigated the impact of modality-specific volumes and other potential stressors on burnout and career-choice satisfaction.

Materials and Methods:
An anonymous survey of 36 questions was sent by email to all 875 faculty members of the STR. These included 11 multiple-choice questions, 23 Likert questions, and 2 free-text questions. The Maslach Burnout Index was used to assess the prevalence of the 3 components of burnout (emotional exhaustion, depersonalization, and low professional accomplishment), and we assessed variations among the potential sources of stress with respect to the respondent sex, career stage, and practice setting. Respondents were asked to estimate daily work volume as if interpreting only chest radiographs (CXRs) or only chest/cardiac computed tomography (CT). Statistical analysis was performed using Excel (Microsoft), open-source statistical computing package pandas and SciPy for Python, and Jupyter Notebook, an open-source interactive computing platform.

Results:
Although financial concerns (49.3%), lack of input into decisions (48.6%), and inadequate staffing (45.2%) were additional stressors, the major sources were work-life balance (67.4%) and workload (66.8%), which were more frequently cited by women than men (78.9% vs. 60.8%, P=0.001). Emotional exhaustion and depersonalization were related to higher CXR volumes. Although 83.2% were satisfied being a diagnostic radiologist, 18.8% had thought of leaving medicine. More than half of all radiologists interpreted ≥150 CXRs daily (51.1% vs. 53.6%); more in private practice read ≥200 CXRs (23.2% vs. 14.7%). Of the academic radiologists, 80.2% interpreted 21 to 49 CTs; twice as many in private practice read ≥50 CTs (25.5% vs. 12.7%).

Conclusions:
The contributing factors to cardiothoracic radiologist burnout vary by sex, career stage, and practice setting. Several stressors, especially work-life balance, were associated with higher burnout prevalence. Most respondents expressed career-choice satisfaction. Defining threshold work volumes associated with higher rates of burnout is an important first step in defining burnout prevention guardrails.
Opportunistic Salpingectomy at the Time of Laparoscopic Cholecystectomy for Ovarian Cancer Prevention
Authors: Matsuo Koji , Chen Ling , Matsuzaki Shinya , Mandelbaum Rachel S. , Ciesielski Katharine M. , Silva Jack P. , Klar Maximilian , Roman Lynda D. , Accordino Melissa K. , Melamed Alexander , Elkin Elena , Hershman Dawn L. , Wright Jason D. 
Published: January 2022

Objective:
To perform a cost-effectiveness analysis to examine the utility and effectiveness of OS performed at the time of elective cholecystectomy [laparoscopic cholecystectomy (LAP-CHOL)].

Summary Background Data:
OS has been adopted as a strategy to reduce the risk of ovarian cancer in women undergoing hysterectomy and tubal sterilization, although the procedure is rarely performed as a risk reducing strategy during other abdominopelvic procedures.

Methods:
A decision model was created to examine women 40, 50, and 60 years of age undergoing LAP-CHOL with or without OS. The lifetime risk of ovarian cancer was assumed to be 1.17%, 1.09%, and 0.92% for women age 40, 50, and 60 years, respectively. OS was estimated to provide a 65% reduction in the risk of ovarian cancer and to require 30 additional minutes of operative time. We estimated the cost, quality-adjusted life-years, ovarian cancer cases and deaths prevented with OS.

Results:
The additional cost of OS at LAP-CHOL ranged from $1898 to 1978. In a cohort of 5000 women, OS reduced the number of ovarian cancer cases by 39, 36, and 30 cases and deaths by 12, 14, and 16 in the age 40–, 50–, and 60-year-old cohorts, respectively. OS during LAP-CHOL was cost-effective, with incremental cost-effectiveness ratio of $11,162 to 26,463 in the 3 age models. In a probabilistic sensitivity analysis, incremental cost-effectiveness ratio for OS were less than $100,000 per quality-adjusted life-years in 90.5% or more of 1000 simulations.

Conclusions:
OS at the time of LAP-CHOL may be a cost-effective strategy to prevent ovarian cancer among average risk women.
The Problem of Appetite Loss After Major Abdominal Surgery
Authors: Wagner Martin , Probst Pascal , Haselbeck-Köbler Michael , Brandenburg Johanna M. , Kalkum Eva , Störzinger Dominic , Kessler Jens , Simon Joe J. , Friederich Hans-Christoph , Angelescu Michaela , Billeter Adrian T. , Hackert Thilo , Müller-Stich Beat P. , Büchler Markus W. 
Published: January 2022

Objective:
To systematically review the problem of appetite loss after major abdominal surgery.

Summary of Background Data:
Appetite loss is a common problem after major abdominal surgery. Understanding of etiology and treatment options is limited.

Methods:
We searched Medline, Cochrane Central Register of Controlled Trials, and Web of Science for studies describing postoperative appetite loss. Data were extracted to clarify definition, etiology, measurement, surgical influence, pharmacological, and nonpharmacological treatment. PROSPERO registration ID: CRD42021224489.

Results:
Out of 6144 articles, we included 165 studies, 121 of which were also analyzed quantitatively. A total of 19.8% were randomized, controlled trials (n = 24) and 80.2% were nonrandomized studies (n = 97). The studies included 20,506 patients undergoing the following surgeries: esophageal (n = 33 studies), gastric (n = 48), small bowel (n = 6), colon (n = 27), rectal (n = 20), hepatobiliary (n = 6), and pancreatic (n = 13). Appetite was mostly measured with the Quality of Life Questionnaire of the European Organization for Research and Treatment of Cancer (EORTC QLQ C30, n = 54). In a meta-analysis of 4 randomized controlled trials gum chewing reduced time to first hunger by 21.2 hours among patients who had bowel surgery. Other reported treatment options with positive effects on appetite but lower levels of evidence include, among others, intravenous ghrelin administration, the oral Japanese herbal medicine Rikkunshito, oral mosapride citrate, multidisciplin-ary-counseling, and watching cooking shows. No studies investigated the effect of well-known appetite stimulants such as cannabinoids, steroids, or megestrol acetate on surgical patients.

Conclusions:
Appetite loss after major abdominal surgery is common and associated with increased morbidity and reduced quality of life. Recent studies demonstrate the influence of reduced gastric volume and ghrelin secretion, and increased satiety hormone secretion. There are various treatment options available including level IA evidence for postoperative gum chewing. In the future, surgical trials should include the assessment of appetite loss as a relevant outcome measure.
Astrocyte biomarker signatures of amyloid-β and tau pathologies in Alzheimer’s disease
Authors: Ferrari-Souza João Pedro , Lukasewicz Ferreira Pâmela C. , Bellaver Bruna , Tissot Cécile , Wang Yi-Ting , Leffa Douglas T. , Brum Wagner S. , Benedet Andréa L. , Ashton Nicholas J. , De Bastiani Marco Antônio , Rocha Andréia , Therriault Joseph , Lussier Firoza Z. , Chamoun Mira , Servaes Stijn , Bezgin Gleb , Kang Min Su , Stevenson Jenna , Rahmouni Nesrine , Pallen Vanessa , Poltronetti Nina Margherita , Klunk William E. , Tudorascu Dana L. , Cohen Annie , Villemagne Victor L. , Gauthier Serge , Blennow Kaj , Zetterberg Henrik , Souza Diogo O. , Karikari Thomas K. , Zimmer Eduardo R. , Rosa-Neto Pedro , Pascoal Tharick A. 
Published: January 2022

AbstractAstrocytes can adopt multiple molecular phenotypes in the brain of Alzheimer’s disease (AD) patients. Here, we studied the associations of cerebrospinal fluid (CSF) glial fibrillary acidic protein (GFAP) and chitinase-3-like protein 1 (YKL-40) levels with brain amyloid-β (Aβ) and tau pathologies. We assessed 121 individuals across the aging and AD clinical spectrum with positron emission tomography (PET) brain imaging for Aβ ([18F]AZD4694) and tau ([18F]MK6240), as well as CSF GFAP and YKL-40 measures. We observed that higher CSF GFAP levels were associated with elevated Aβ-PET but not tau-PET load. By contrast, higher CSF YKL-40 levels were associated with elevated tau-PET but not Aβ-PET burden. Structural equation modeling revealed that CSF GFAP and YKL-40 mediate the effects of Aβ and tau, respectively, on hippocampal atrophy, ultimately leading to cognitive impairment. Our results suggest the existence of distinct astrocyte biomarker signatures in response to brain Aβ and tau accumulation, which may contribute to our understanding of the complex link between reactive astrogliosis heterogeneity and AD progression.
Investigating childhood maltreatment as a modifier of genetic risk for cardiovascular disease in the UK Biobank
Authors: Urquijo Helena , Soares Ana Gonçalves , Fraser Abigail , Howe Laura D , Carter Alice R 
Published: January 2022

AbstractCardiovascular disease (CVD) is influenced by genetic and environmental factors. Childhood maltreatment is associated with CVD and may modify genetic susceptibility to cardiovascular risk factors. We used genetic and phenotypic data from 100,833 White British UK Biobank participants (57% female; mean age = 55.9 years). We regressed nine cardiovascular risk factors/diseases (alcohol consumption, body mass index [BMI], low-density lipoprotein cholesterol, lifetime smoking behaviour, systolic blood pressure, atrial fibrillation, coronary heart disease, type 2 diabetes, and stroke) on their respective polygenic scores (PGS) and self-reported exposure to childhood maltreatment. Effect modification was tested on the additive and multiplicative scales by including a product term (PGS*maltreatment) in regression models.On the additive scale, childhood maltreatment accentuated the effect of genetic susceptibility to higher BMI. Individuals not exposed to childhood maltreatment had an increase in BMI of 0.12 SD (95% CI: 0.11, 0.13) per SD increase in BMI PGS, compared to 0.17 SD (95% CI: 0.14, 0.19) in those exposed to all types of childhood maltreatment. On the multiplicative scale, similar results were obtained for BMI though these did not withstand to Bonferroni correction. There was little evidence of effect modification by childhood maltreatment in relation to other outcomes, or of sex-specific effect modification.Our study suggests the effects of genetic susceptibility to a higher BMI may be moderately accentuated in individuals exposed to childhood maltreatment. However, gene*environment interactions are likely not a major contributor to the excess CVD burden experienced by childhood maltreatment victims.
Graph Convolutional Neural Networks for Histological Classification of Pancreatic Cancer
Authors: Wu Weiyi , Liu Xiaoying , Hamilton Robert B. , Suriawinata Arief A. , Hassanpour Saeed 
Published: January 2022

ABSTRACTPancreatic ductal adenocarcinoma has some of the worst prognostic outcomes among various cancer types. Detection of histologic patterns of pancreatic tumors is essential to predict prognosis and decide about the treatment for patients. This histologic classification can have a large degree of variability even among expert pathologists. This study proposes a graph convolutional network-based deep learning model to detect aggressive adenocarcinoma and less aggressive pancreatic tumors from benign cases. Our model uses a convolutional neural network to extract detailed information from every small region in a whole-slide image. Then, we use a graph architecture to aggregate the extracted features from these regions and their positional information to capture the whole-slide level structure and make the final prediction. We evaluated our model on an independent test set and achieved an F1 score of 0.85 for detecting neoplastic cells and ductal adenocarcinoma, significantly outperforming other baseline methods. If validated in prospective studies, this approach has a great potential to assist pathologists in identifying adenocarcinoma and other types of pancreatic tumors in clinical settings.
INCIDENCE OF HEPATITIS B AND C VIRUSES AMONG THE SCAVENGERS IN KWARA STATE, NIGERIA
Authors: Raufu Yusuf Olanrewaju , Olayinka Adewoye Solomon , Olawale Sawyerr Henry , Raimi Morufu Olalekan 
Published: January 2022

AbstractBackgroundPoor economic situations in developing nations had made scavenging a means of livelihood for millions of youth and women across the globe. Lack of proper source segregation of wastes in developing countries has increased the potential for the transmission of pathogens like Hepatitis B Virus (HBV) and Hepatitis C Virus (HCV).ObjectivesThis study addressed issues relating to waste scavenging, the potential risk in waste scavenging work and seroprevalence of Hepatitis B and C Virus and its relationship with wastes scavenging among wastes scavengers in Kwara State.MethodsA cross-sectional study was conducted among the scavengers working for major scrap dealers in the three senatorial districts of Kwara State. Consequently, to accomplish the objectives, both primary and secondary data sources were used. The primary data were collected via questionnaires, interviews, blood test and field observations. Whereas the secondary data were extracted from different published and unpublished materials. 240 respondents were administered with questionnaires and undergone hepatitis surface antigen test for both hepatitis B and C in nine of the sixteen local government area in the state. The data were analyzed using statistical package for social science (SPSS version 23) for descriptive and inferential at 5% level of significance. The prevalence of an HBV and HCV infection biological markers (HBsAg and HCsAg) and their associations with exposure to bio-medical waste, socio-demographic factors, and history of occupational injuries was examined.ResultsThe seroprevalence of HBV and HCV infection among the scavengers were found to be 8.3% and 5% respectively indicating that scavengers are at risk of HBV and HCV infection.ConclusionsIt was discovered that there are incidences of Hepatitis B and C virus co-infection among scavengers. Also, awareness and compliance to the usage of PPE was found to be an important factor for protection scavengers against the virus. Therefore, vaccination against HBV, enforcement of usage of PPE, good hygiene practices, regular trainings on occupational safety, proper monitoring by regulatory agency and inclusion of scavengers in mandatory health insurance scheme will help to control risk of HBV and HCV infection among scavengers.
A model-based approach to improve intranasal sprays for respiratory viral infections
Authors: Basu Saikat , Akash Mohammad Mehedi Hasan , Lao Yueying , Balivada Pallavi A , Ato Phoebe , Ka Nogaye K , Mituniewicz Austin , Silfen Zachary , Suman Julie , Chakravarty Arijit , Joseph-McCarthy Diane 
Published: January 2022

AbstractDrug delivery for viral respiratory infections, such as SARS-CoV-2, can be enhanced significantly by targeting the nasopharynx, which is the dominant initial infection site in the upper airway, for example by nasal sprays. However, under the standard recommended spray usage protocol (“Current Use”, or CU), the nozzle enters the nose almost vertically, resulting in sub-optimal deposition of drug droplets at the nasopharynx. Using computational fluid dynamics simulations in two anatomic nasal geometries, along with experimental validation of the generic findings in a different third subject, we have identified a new “Improved Use” (or, IU) spray protocol. It entails pointing the spray bottle at a shallower angle (almost horizontally), aiming slightly toward the cheeks. We have simulated the performance of this protocol for conically injected spray droplet sizes of 1 – 24 μm, at two breathing rates: 15 and 30 L/min. The lower flowrate corresponds to resting breathing and follows a viscous-laminar model; the higher rate, standing in for moderate breathing conditions, is turbulent and is tracked via Large Eddy Simulation. The results show that (a) droplets sized between ∼ 6 – 14 μm are most efficient at direct landing over the nasopharyngeal viral infection hot-spot; and (b) targeted drug delivery via IU outperforms CU by approximately 2 orders-of-magnitude, under the two tested inhalation conditions. Also quite importantly, the improved delivery strategy, facilitated by the IU protocol, is found to be robust to small perturbations in spray direction, underlining the practical utility of this simple change in nasal spray administration protocol.
Accelerated waning of immunity to SARS-CoV-2 mRNA vaccines in patients with immune mediated inflammatory diseases
Authors: Dayam Roya M. , Law Jaclyn C. , Goetgebuer Rogier L. , Chao Gary Y. C. , Abe Kento T. , Sutton Mitchell , Finkelstein Naomi , Stempak Joanne M. , Pereira Daniel , Croitoru David , Acheampong Lily , Rizwan Saima , Rymaszewski Klaudia , Milgrom Raquel , Ganatra Darshini , Batista Nathalia V. , Girard Melanie , Lau Irene , Law Ryan , Cheung Michelle W. , Rathod Bhavisha , Kitaygorodsky Julia , Samson Reuben , Hu Queenie , Hardy W. Rod , Haroon Nigil , Inman Robert D. , Piguet Vincent , Chandran Vinod , Silverberg Mark S. , Gingras Anne-Claude , Watts Tania H. 
Published: January 2022

ABSTRACTBackgroundLimited information is available on the impact of immunosuppressants on COVID-19 vaccination in patients with immune-mediated inflammatory diseases (IMID).MethodsThis observational cohort study examined the immunogenicity of SARS-CoV-2 mRNA vaccines in adult patients with inflammatory bowel disease, rheumatoid arthritis, ankylosing spondylitis, or psoriatic disease, with or without maintenance immunosuppressive therapies. Antibody and T cell responses to SARS-COV-2, including neutralization against SARS-CoV-2 variants were determined before and after 1 and 2 vaccine doses.ResultsWe prospectively followed 150 subjects, 26 healthy controls, 9 IMID patients on no treatment, 44 on anti-TNF, 16 on anti-TNF with methotrexate/azathioprine (MTX/AZA), 10 on anti-IL-23, 28 on anti-IL-12/23, 9 on anti-IL-17, and 8 on MTX/AZA. Antibody and T cell responses to SARS-CoV-2 were detected in all participants, increasing from dose 1 to dose 2 and declining 3 months later, with greater attrition in IMID patients compared to healthy controls. Antibody levels and neutralization efficacy against variants of concern were substantially lower in anti-TNF treated patients than in healthy controls and were undetectable against Omicron by 3 months after dose 2.ConclusionsOur findings support the need for a third dose of mRNA vaccine and for continued monitoring of immunity in these patient groups.FundingFunded by a donation from Juan and Stefania Speck and by Canadian Institutes of Health (CIHR) /COVID-Immunity Task Force (CITF) grants VR-1 172711 and VS1-175545 (T.H.W. and A.C.G); CIHR FDN-143250 (T.H.W.), GA2-177716 (V.C., A.C.G., T.W.), GA1-177703 (A.C.G.) and the CIHR rapid response network to SARS-CoV-2 variants, CoVaRR-Net (to A.C.G.).