bluuebunny/crossref_metadata_2025_split huggingface dataset:
Investigation into wideband electromagnetic stealth device based on plasma array and radar-absorbing materials
Authors: DENG Xuesong , DING Chenglong , WANG Yahui , LI Zhigang , CHENG Li , CHEN Zongsheng , LV Xiangyin , SHI Jiaming 
Published: July 2022

Abstract
Manipulation of electromagnetic waves is essential to various microwave applications, and absorbing devices composed of low-pressure gas discharge tubes and radar-absorbing materials (RAM) can bring new solutions to broadband electromagnetic stealth. The microwave transmission method is used to measure the physical parameters of the plasma unit. The designed structure exhibits superior absorption performance and radar cross-section (RCS) reduction capability in the 2–18 GHz band, with unique absorption advantage in the S and C frequency bands. It is found that the combination of the plasma and the RAM can significantly broaden the absorption frequency band and improve the absorption performance with excellent synergistic stealth capability. Experimental and simulation results present that broadband, wide-angle, tunable electromagnetic wave absorption and RCS reduction can be achieved by adjusting the spatial layout of the combined plasma layer and the type of RAMs, which creates opportunities for microwave transmission and selective stealth of equipment. Therefore, the wave manipulation by combined plasma array and RAM provides a valuable reference for developing numerous applications, including radar antenna stealth, spatial filter, and high power microwave shielding.
GHSR1a deficiency suppresses inhibitory drive on dCA1 pyramidal neurons and contributes to memory reinforcement
Authors: Li Na , Li Nan , Yang Liu , Gu Huating , Ji Junjie , Zhou Hao , Zhu Qianqian , Yu Ming , Sun Yuxiang , Zhou Yu 
Published: July 2022

AbstractGrowth hormone secretagogue receptor 1a (GHSR1a)—the receptor for orexigenic hormone ghrelin—is a G protein-coupled receptor that is widely distributed in the brain, including the hippocampus. Studies have demonstrated that genetic deletion of GHSR1a affects memory, suggesting the importance of ghrelin/GHSR1a signaling in cognitive control. However, current reports are controversial, and the mechanism underlying GHSR1a modulation of memory is uncertain. Here, we first report that global GHSR1a knockout enhances hippocampus-dependent memory, facilitates initial LTP in dorsal hippocampal Schaffer Collateral-CA1 synapses, and downregulates Akt activity in the hippocampus. Moreover, we show that the intrinsic excitability of GAD67+ interneurons—rather than neighboring pyramidal neurons in the dCA1—is suppressed by GHSR1a deletion, an effect that is antagonized by acute application of the Akt activator SC79. In addition, the inhibitory postsynaptic currents (IPSCs) on dCA1 pyramidal neurons are selectively reduced in mice with a GHSR1a deficiency. Finally, we demonstrate that selectively increasing the excitability of parvalbumin-expressing interneurons by hM3Dq-DREADDs increases IPSCs on dCA1 pyramidal neurons and normalizes memory in Ghsr1a KO mice. Our findings thus reveal a novel mechanism underlying memory enhancement of GHSR1a deficiency and herein support an adverse effect of GHSR1a signaling in hippocampus-dependent memory processes.
Harmonization Status of Serum Ferritin Measurements and Implications for Use as Marker of Iron-Related Disorders
Authors: Braga Federica , Pasqualetti Sara , Frusciante Erika , Borrillo Francesca , Chibireva Mariia , Panteghini Mauro 
Published: July 2022

Abstract

Background
Serum ferritin is considered a suitable biomarker of iron-related disorders. However, data about the comparability of results among commercial measuring systems (MSs) are contradictory. We performed an intercomparison study aimed at verifying the current interassay variability and its impact on clinical application of the test. Obtaining this information is vital because manufacturers continue to claim calibration alignment to different WHO preparations, which are not related to each other in terms of traceability.

Methods
Four widely used MSs were evaluated. The interassay agreement was verified using 39 human serum pools. The recovery of WHO International Standard (IS) 94/572 (the only reference material available at the time of the study) was evaluated, after assessing the material commutability. Finally, an approach for harmonizing ferritin results was proposed.

Results
Highly significant differences (P &lt; 0.00001) among ferritin concentrations assayed by different MSs were detected and the interassay CV (median 22.9%; interquartile range 21.8–25.5) overlapped the desirable intermethod bias (24.6%). IS 94/572 was commutable for use only with Access and Centaur, with Access being the only MS correctly recovering its assigned value. Accordingly, we used regression data against Access to recalibrate MSs, indirectly aligning them to IS 94/572, with a substantial improvement in degree of harmonization and traceability to higher-order reference.

Conclusions
The harmonization among evaluated ferritin MSs is far from optimal, with the implementation of traceability to different WHO ISs being a factor of confusion. A recalibration approach, however, would permit measurement harmonization, allowing the use of common decision thresholds.
Endoscopic versus fluoroscopic esophageal dilatations in children with esophageal strictures: 10-year experience
Authors: Marom Adi , Davidovics Zev , Bdolah-Abram Tali , Ledder Oren 
Published: July 2022

Summary
Esophageal strictures in children may cause dysphagia, choking during feeds, and failure to thrive. They can be treated by balloon dilatations, either under endoscopic or fluoroscopic guidance; there is no literature comparing the methods. Retrospective review of the medical records of children (0–18 years) who were treated with balloon dilatations between 2010 and 2020. The primary outcome was the number of dilatation sessions required until clinical success after 3 months. Secondary outcomes were long-term success at 12 months, and complications of bleeding and perforation. Forty-six patients underwent 174 dilatation sessions. Success rates in the endoscopy and fluoroscopy groups were similar: 62% versus 67% (p = 0.454) at 3 months and 57% versus 67% (p = 0.721) at 12 months. Complication rate was lower in the endoscopy group (0% vs. 15%, p &lt; 0.001). Both endoscopic and radiologic-guided balloon dilatations were shown to be equally effective, but endoscopic guidance had fewer complications.
Genetic Variation and Population Structure of the Old World Bollworm Helicoverpa armigera (Hübner, 1808) (Lepidoptera: Noctuidae) in Ethiopia
Authors: Fite Tarekegn , Tefera Tadele , Husemann Martin , Getaneh Gezahegne , Villinger Jandouwe 
Published: July 2022

Abstract
Helicoverpa armigera is one of the most destructive insect pests of economically valuable crops in the world. Despite its economic importance, the population genetic structure of this insect remains unexplored in Ethiopia. To investigate the genetic diversity and population structure of H. armigera, we sampled 170 individuals from 15 populations throughout Ethiopia. We sequenced a fragment of the mitochondrial cytochrome b (cyt b) gene and five exon-primed intron-crossing (EPIC) markers. Twenty cyt b haplotypes with low-to-moderate haplotype diversity (mean Hd = 0.537) and high nucleotide diversity (mean Pi = 0.00339) were identified. The most frequently observed and widely distributed cyt b haplotype was designated as Hap_1 (67.058%), which is identical to sequences found across the globe. Tajima’s D and Fu’s F for the cyt b data were negative, supporting a model of population expansion. Within populations, a mean of 2.493 alleles/locus was recorded across the five EPIC loci, ranging from 1.200 to 3.600 alleles/locus. The highest mean effective number of alleles/population was 2.369 and the lowest was 1.178. The mean observed heterozygosity (HO) of the five loci (0–0.289; mean 0.104 ± 0.020) was lower than the expected heterozygosity (HE) (0.095–0.523; mean 0.258 ± 0.028). AMOVA detected significant genetic structure with 61% of the total molecular genetic variation of EPIC genotypes occurring between populations, suggesting a considerable degree of differentiation among populations. STRUCTURE analyses clustered the H. armigera populations into three distinct population groups but very low isolation by distance (R2 = 0.0132, P &lt; 0.05).
Intergovernmental Yet Dynamically Expansive: Concordance Legalization as an Alternative Regional Trading Arrangement in ASEAN and Beyond
Authors: Tan Hsien-Li 
Published: July 2022

Abstract
The conventional regional trading arrangement landscape holds two primary models. One is the ‘dynamically expansive supranational model’ of the European Union (EU) that progressively enlarges its community beyond the constituent treaty through its evolving laws and institutions. The other is the ‘static intergovernmental model’ of the United States-Mexico-Canada Agreement (USMCA) where members strictly uphold obligations in the original agreement – no more and no less. A certain genre of Asia-Pacific regional trading arrangements (and beyond in the global South) sits uncomfortably within this bifurcated landscape. Sovereignty-centric, they seek a dynamic and ever-expanding community like the EU but, firmly rejecting supranationalism, insist on intergovernmental modalities as seen in the USMCA. Unsurprisingly, they have not been effective. Using post-2007 integration data from the Association of Southeast Asian Nations, this article presents concordance legalization as a new explanatory framework in this landscape, demonstrating how one can regionalize successfully despite being simultaneously agenda expansive and intergovernmentally operational. Concordance legalization’s four-pronged strategy – the constituent treaty explicitly entrenching intergovernmentalism to facilitate dynamic agenda expansion; the dual-step system of primary and secondary laws (with a carefully calibrated use of hard and soft instruments); the organizational hierarchy that expands, implements and exerts intra-regional accountability pressures through numerous meetings and monitoring mechanisms (rather than adjudication) that enforce compliance – has enabled this curious success.
Fertility History and Risk of Cognitive Impairment Among Older Parents in the United States
Authors: Zhang Yan 
Published: July 2022

Abstract

Objectives
I work from a gendered life-course perspective to examine the association between older parents’ fertility history (i.e., timing and parity) and their risk of cognitive impairment in the United States.

Methods
I analyze nationally representative data from 9 waves over 16 years of the Health and Retirement Study (2000–2016). The sample includes 14,543 respondents (6,108 men and 8,435 women) aged 50 and older at the baseline survey. I examine the relationship between parity, age at first birth, and age at last birth with risk of cognitive impairment using nonlinear discrete-time hazard models.

Results
Adjusting for the effects of full covariates, there are U-shaped relationships between women’s age at last birth and risk of cognitive impairment and between women’s parity and risk of cognitive impairment. In the sensitivity tests, the relationships remain robust when sampling weights are applied, or mortality selection is corrected.

Discussion
Fertility timing and parity are likely factors associated with the risk of cognitive impairment for older women. Understanding fertility history and its impact on cognition can help identify the most vulnerable subpopulations, so that more effective interventions can be made to improve cognitive functioning among older adults.
Everyday Justice: Legal Aid for Jewish Displaced Persons, Germany, 1945–1950
Authors: Brot Rivka 
Published: July 2022

Abstract
Welfare workers volunteering with the American Jewish Joint Distribution Committee (JDC), a Jewish welfare organization, delivered crucial legal assistance to Holocaust survivors gathered in displaced persons (DP) camps in the American Zone of occupied Germany; however, today their story is largely forgotten. Their legal aid program embodied a unique relationship between social work and law. JDC relief workers developed a legal consciousness in response to the many injustices they witnessed in the DP camps, which allowed them to identify the gap between the basic support provided by relief programs, and the actual needs of the DPs. From this awareness they gradually developed a program of legal welfare, assisted Jews in their daily interactions with Americans and Germans, provided them with legal instruction and education, and protected them when conflicts arose. These JDC volunteers were fueled by a sense of moral responsibility and compassion for the Jewish DPs, who were forced to live in a foreign and often hostile environment. Remarkably, this story has largely been neglected in Holocaust scholarship, though the archives have yielded hundreds of reports by JDC welfare workers, as well as the papers of Oskar Mintzer, a key figure in the creation of the JDC’s legal aid program. The JDC was at the forefront of an unprecedented humanitarian crisis, and this aspect of its work represents a forgotten milestone in the development of a more holistic approach to refugee assistance and support. This study offers a starting point for further research in order to better understand humanitarian aid for asylum seekers, DPs, and refugees in the twenty-first century.
Comparative genomic analyses of multiple backcross mouse populations suggestSGCGas a novel potential obesity-modifier gene
Authors: Kuhn Tanja , Kaiser Katharina , Lebek Sandra , Altenhofen Delsi , Knebel Birgit , Herwig Ralf , Rasche Axel , Pelligra Angela , Görigk Sarah , Khuong Jenny Minh-An , Vogel Heike , Schürmann Annette , Blüher Matthias , Chadt Alexandra , Al-Hasani Hadi 
Published: July 2022

AbstractTo nominate novel disease genes for obesity and type 2 diabetes (T2D), we recently generated two mouse backcross populations of the T2D-susceptible New Zealand Obese (NZO/HI) mouse strain and two genetically different, lean and T2D-resistant strains, 129P2/OlaHsd and C3HeB/FeJ. Comparative linkage analysis of our two female backcross populations identified seven novel body fat-associated quantitative trait loci (QTL). Only the locus Nbw14 (NZO body weight on chromosome 14) showed linkage to obesity-related traits in both backcross populations, indicating that the causal gene variant is likely specific for the NZO strain as NZO allele carriers in both crosses displayed elevated body weight and fat mass. To identify candidate genes for Nbw14, we used a combined approach of gene expression and haplotype analysis to filter for NZO-specific gene variants in gonadal white adipose tissue, defined as the main QTL-target tissue. Only two genes, Arl11 and Sgcg, fulfilled our candidate criteria. In addition, expression QTL analysis revealed cis-signals for both genes within the Nbw14 locus. Moreover, retroviral overexpression of Sgcg in 3T3-L1 adipocytes resulted in increased insulin-stimulated glucose uptake. In humans, mRNA levels of SGCG correlated with body mass index and body fat mass exclusively in diabetic subjects, suggesting that SGCG may present a novel marker for metabolically unhealthy obesity. In conclusion, our comparative-cross analysis could substantially improve the mapping resolution of the obesity locus Nbw14. Future studies will throw light on the mechanism by which Sgcg may protect from the development of obesity.
Basolateral Amygdala SIRT1/PGC-1α Mitochondrial Biogenesis Pathway Mediates Morphine Withdrawal-Associated Anxiety in Mice
Authors: Yin Fangyuan , Zhang Jinyu , Liu Yige , Zhai Yifang , Luo Danlei , Yan Xinyue , Feng Yue , Lai Jianghua , Zheng Haibo , Wei Shuguang , Wang Yunpeng 
Published: July 2022

Abstract

Background
Anxiety is a negative emotion that contributes to craving and relapse during drug withdrawal. Sirtuins 1 (SIRT1) has been reported to be critical in both negative emotions and drug addiction. However, it remains incompletely elucidated whether SIRT1 is involved in morphine withdrawal-associated anxiety.

Methods
We established a mouse model of anxiety-like behaviors induced by morphine withdrawal and then detected neuronal activity with immunofluorescence and mitochondrial morphology with electron microscopy, mitochondrial DNA contents with quantitative real-time PCR, and mitochondrial function with the ATP content detection kit and the Mitochondrial Complex IV Activity Kit in the basolateral amygdala (BLA). The mitochondrial molecules were detected by western blot. Then we used virus-mediated downregulation and overexpression of SIRT1 in BLA to investigate the effect of SIRT1 on anxiety and mitochondrial function. Finally, we examined the effects of pharmacological inhibition of SIRT1 on anxiety and mitochondrial function.

Results
We found that BLA neuronal activity, mitochondrial function, and mtDNA content were significantly higher in morphine withdrawal mice. Furthermore, the expression levels of mitochondrial molecules increased in BLA cells. Virus-mediated downregulation of SIRT1 in BLA prevented anxiety-like behaviors in morphine withdrawal mice, whereas overexpression of SIRT1 in BLA facilitated anxiety-like behaviors in untreated mice through the SIRT1/ peroxisome proliferator activated receptor gamma coactivator 1-alpha pathway. Intra-BLA infusion of selective SIRT1 antagonist EX527 effectively ameliorated anxiety-like behaviors and mitochondrial dysfunction in mice with morphine withdrawal.

Conclusion
Our results implicate a causal role for SIRT1 in the regulation of anxiety through actions on mitochondrial biogenesis. Inhibitors targeting SIRT1 may have therapeutic potential for the treatment of opioid withdrawal-associated anxiety.
Prevalence and factors associated with faecal carriage of extended-spectrum β-lactamase-producing Enterobacterales among peripartum women in the community in Cambodia
Authors: de Lauzanne Agathe , Sreng Navin , Foucaud Elsa , Sok Touch , Chon Thida , Yem Chhaily , Hak Veasna , Heng Sothada , Soda Meng , Gouali Malika , Nadimpalli Maya , Inghammar Malin , Rabenandrasana Mamitina Alain Noah , Collard Jean Marc , Vray Muriel , Hello Simon Le , Kerleguer Alexandra , Piola Patrice , Delarocque-Astagneau Elisabeth , Guillemot Didier , Huynh Bich Tram , Borand Laurence ,   BIRDY study group, Zo Andrianirina Zafitsara , Diatta Marguerite , Diouf Jean Baptiste , Sarr Fatoumata Diene , Faye Joseph , Goyet Sophie , Herindrainy Perlinot , Kermorvant-Duchemin Elsa , Lach Siyin , Ngo Veronique , Padget Michael , Rakotoarimanana Feno Manitra Jacob , Raheliarivao Bodonirina Tanjona , Randrianirina Frédérique , Seck Abdoulaye , Tarantola Arnaud , Youssouf Armya Abdou 
Published: July 2022

Abstract

Background
In Southeast-Asia, where many conditions associated with dissemination of ESBL-producing Enterobacterales (ESBL-E) in the community are met, data from the community are scarce but show high ESBL-E carriage prevalence. Maternal ESBL-E colonization is considered a risk factor for neonatal colonization, which is the first step towards developing neonatal sepsis. Despite this, ESBL-E carriage prevalence and its risk factors during pregnancy or postpartum remain undefined in Southeast-Asia.

Objectives
To estimate the prevalence of ESBL-E faecal colonization among peripartum women in the community of an urban and a rural area in Cambodia, to investigate ESBL-E genomic characteristics and to identify associated risk factors.

Methods
Epidemiological data and faecal samples from 423 peripartum women were collected in an urban and rural areas in Cambodia (2015–16). Bacterial cultures, antibiotic susceptibility tests and ESBL gene sequencing were performed. Risk factor analysis was conducted using logistic regression.

Results
The prevalence of ESBL-E faecal carriage was 79.2% (95% CI 75.0%–82.8%) among which Escherichia coli (n = 315/335, 94.0%) were most frequent. All isolates were multidrug resistant. Among 318 ESBL-E, the genes most frequently detected were blaCTX-M-15 (41.5%), blaCTX-M-55 (24.8%), and blaCTX-M-27 (15.1%). Low income, undernutrition, multiparity, regular consumption of pork, dried meat, and raw vegetables, were associated with ESBL-E faecal carriage.

Conclusions
The high prevalence of ESBL-E carriage observed among peripartum women in Southeast-Asia and the identified associated factors underline the urgent need for public health measures to address antimicrobial resistance, including a ‘One Health’ approach.
Randomized Controlled Trial of Ketamine and Moderate Sedation for Outpatient Endoscopy in Adults
Authors: Edelson Jerome C , Edelson Cyrus V , Rockey Don C , Morales Amilcar L , Chung Kevin K , Robles Matthew J , Marowske Johanna H , Patel Anish A , Edelson Scott F. D , Subramanian Stalin R , Gancayco John G 
Published: July 2022

ABSTRACT

Introduction
Ketamine is an effective sedative agent in a variety of settings due to its desirable properties including preservation of laryngeal reflexes and lack of cardiovascular depression. We hypothesized that ketamine is an effective alternative to standard moderate sedation (SMS) regimens for patients undergoing endoscopy.

Materials and Methods
We conducted a randomized controlled trial comparing ketamine to SMS for outpatient colonoscopy or esophagogastroduodenoscopy at Brooke Army Medical Center. The ketamine group received a 1-mg dose of midazolam along with ketamine, whereas the SMS group received midazolam/fentanyl. The primary outcome was patient satisfaction measured using the Patient Satisfaction in Sedation Instrument, and secondary outcomes included changes in hemodynamics, time to sedation onset and recovery, and total medication doses.

Results
Thirty-three subjects were enrolled in each group. Baseline characteristics were similar. Endoscopies were performed for both diagnostic and screening purposes. Ketamine was superior in the overall sedation experience and in all analyzed categories compared to the SMS group (P = .0096). Sedation onset times and procedure times were similar among groups. The median ketamine dose was 75 mg. The median fentanyl and midazolam doses were 150 mcg and 5 mg, respectively, in SMS. Vital signs remained significantly closer to the physiological baseline in the ketamine group (P = .004). Recovery times were no different between the groups, and no adverse reactions were encountered.

Conclusions
Ketamine is preferred by patients, preserves hemodynamics better than SMS, and can be safely administered by endoscopists. Data suggest that ketamine is a safe and effective sedation option for patients undergoing esophagogastroduodenoscopy or colonoscopy (clinicaltrials.gov NCT03461718).
Our Galaxy’s youngest disc
Authors: Li Chengdong , Binney James 
Published: July 2022

ABSTRACT
We investigate the structure of our Galaxy’s young stellar disc by fitting the distribution functions (DFs) of a new family to 5D Gaia data for a sample of $47\, 000$ OB stars. Tests of the fitting procedure show that the young disc’s DF would be strongly constrained by Gaia data if the distribution of Galactic dust were accurately known. The DF that best fits the real data accurately predicts the kinematics of stars at their observed locations, but it predicts the spatial distribution of stars poorly, almost certainly on account of errors in the best-available dust map. We argue that dust models could be greatly improved by modifying the dust model until the spatial distribution of stars predicted by a DF agreed with the data. The surface density of OB stars is predicted to peak at $R\simeq 5.5\, \mathrm{kpc}$, slightly outside the reported peak in the surface density of molecular gas; we suggest that the latter radius may have been underestimated through the use of poor kinematic distances. The velocity distributions predicted by the best-fitting DF for stars with measured line-of-sight velocities v∥ reveal that the outer disc is disturbed at the level of $10\, \mathrm{km\, s}^{-1}$ in agreement with earlier studies, and that the measured values of v∥ have significant contributions from the orbital velocities of binaries. Hence the outer disc is colder than it is sometimes reported to be.