bluuebunny/crossref_metadata_2025_split huggingface dataset:
“Wanting” versus “needing” related value: An fMRI meta‐analysis
Authors: Bosulu Juvenal , Allaire Max‐Antoine , Tremblay‐Grénier Laurence , Luo Yi , Eickhoff Simon , Hétu Sébastien 
Published: August 2022

AbstractConsumption and its excesses are sometimes explained by imbalance of need or lack of control over “wanting.” “Wanting” assigns value to cues that predict rewards, whereas “needing” assigns value to biologically significant stimuli that one is deprived of. Here we aimed at studying how the brain activation patterns related to value of “wanted” stimuli differs from that of “needed” stimuli using activation likelihood estimation neuroimaging meta‐analysis approaches. We used the perception of a cue predicting a reward for “wanting” related value and the perception of food stimuli in a hungry state as a model for “needing” related value. We carried out separate, contrasts, and conjunction meta‐analyses to identify differences and similarities between “wanting” and “needing” values. Our overall results for “wanting” related value show consistent activation of the ventral tegmental area, striatum, and pallidum, regions that both activate behavior and direct choice, while for “needing” related value, we found an overall consistent activation of the middle insula and to some extent the caudal‐ventral putamen, regions that only direct choice. Our study suggests that wanting has more control on consumption and behavioral activation.
Bridging the gap between state–business interactions and air pollution: The role of environment, social responsibility, and corporate governance performance
Authors: Meng Guanfei , Li Jianglong , Yang Xiuwang 
Published: August 2022

AbstractCompared with the impact of listed corporates' environment, social responsibility, and corporate governance (ESG) on financing and market value, considerably less attention is paid to the role of ESG performance in improving environmental quality in China. However, exploring the environmental motivation of listed corporates' ESG engagement is vital for shareholder protection and corporate strategic development under state–business interactions. Thus, we study the relationship between state–business interactions and air pollution from the perspective of ESG using the dataset of Chinese listed corporates. The results demonstrate that the state–business collusion interactions increase air pollution by hindering the fulfillment of ESG. Meanwhile, this impact of heavy pollution corporates is higher than that of industrial corporates. However, the deleterious relationship might be largely improved when state–business interactions are “clean.” Finally, we observe that ESG mediates the relationship between state–business interactions and pollutants.
Risk of cutaneous adverse events in cancer patients treated with phosphatidylinositol‐3‐kinase inhibitors: A systematic review and meta‐analysis of randomized controlled trials
Authors: Wang Yushu , Ma Zhuo , An Zhuoling , Zhang Yi , Feng Xin , Yu Xiaojia 
Published: August 2022

AbstractBackgroundCutaneous adverse effects (AEs) are common following the phosphoinositide‐3‐kinase (PI3K) inhibitors treatment. We aim to estimate the incidence and risk of PI3K inhibitor‐related cutaneous AEs.MethodsThe protocol was submitted to the PROSPERO registry. We searched ClinicalTrials.gov and international databases up to July 29, 2022. Meta‐analysis was conducted by using risk ratios (RRs) with 95% confidence intervals (CIs).ResultsFourteen randomized controlled trials (RCTs) comprising 3877 patients were analyzed in this study. Compared with control arms, PI3K inhibitors showed a significant increase in the risk of all‐grade rash, high‐grade rash, and serious rash events (RR 2.29, 95% CI 1.58–3.31, p < 0.00001; RR 9.34, 95% CI 4.21–20.69, p < 0.00001; RR 5.11, 95% CI 2.11–12.36, p = 0.0003). The overall incidences of all‐grade rash and high‐grade rash were 26.2% (592/2257) and 4.4% (66/1487). Subgroup analyses of all‐grade rash according to cancer types and PI3K inhibitor assignations identified the significant associations. PI3K inhibitors also significantly increased the risk of pruritus and dry skin (RR 1.63, 95% CI 1.14–2.33, p = 0.007; RR 3.34, 95% CI 2.30–4.85, p < 0.00001), with incidences of 13.4% (284/2115) and 9.8% (141/1436) in the treatment group.ConclusionThere is a significantly increased risk of some cutaneous AEs in patients using PI3K inhibitors. Advance intervention is recommended in case of severe and life‐threatening events. Further research is required to investigate the risk factors and pathogenesis.
Sequencing of cerebrospinal fluid in non‐small‐cell lung cancer patients with leptomeningeal metastasis: A systematic review
Authors: Gao Tianqi , Chen Fengxi , Li Man 
Published: August 2022

AbstractLeptomeningeal metastasis (LM) refers to the dissemination of malignant cells in the subarachnoid space, pia, and arachnoid mater and is a severe condition associated with metastatic solid tumors. The most common solid tumor that develops into LM is lung cancer and the incidence increased in patients with advanced non‐small‐cell lung cancer (NSCLC) with targetable mutations. However, tissue biopsy of LM is inaccessible, leading to the paucity of genomic profiles of LM to guide targeted treatments and explore biological mechanisms. In recent years, liquid biopsy is considered a minimally invasive and dynamic method to trace the genomic alterations of cancer cells and some studies started to perform sequencing of cerebrospinal fluid (CSF) in patients with LM to reveal the targeted mutations and genomic profiles. In this review, we focused on studies performed sequencing of CSF in NSCLC patients with LM and summarized the sequencing results and their commonality. As the only way to reveal the genomic landscapes of LM, our review provided evidence that sequencing of CSF is a promising management method in LM patients to dynamically guide target therapy and monitor intracranial tumor response. Furthermore, it reveals a unique genomic profile of LM including driver genes, drug‐resistant mutations, and a number of copy number variations. Sequencing of CSF in LM patients seems to provide more comprehensive genomic information than we expected and the biological significance behind the genomic alternations needs further study.
Exploring the influencing factors of wall‐following behavior in a virtual reality fire evacuation game
Authors: Wang Jing , Liu Tingting , Liu Zhen , Chai Yanjie 
Published: August 2022

AbstractIn most of fire evacuation, people follow the walls. The reasons behind this escape behavior have not been verified by experiments. In this article, we design a virtual reality (VR) fire evacuation game with realistic virtual environment to explore the effects of smoke concentration, individual familiarity with the environment, and neighbor behavior on individual wall‐following behavior. Individuals' familiarity with the environment is obtained through experimental training and the frequencies of their behavior along the wall at different smoke concentrations are recorded. From a subjective perspective, we use the presence scale to assess the immersion of the designed VR game. The results show that users have a good level of presence in the designed VR game. From an objective perspective, we analyze the game data using a statistically based approach. The analysis shows that high concentration of smoke, unfamiliar with the environment will increase individuals' reliance on walls, but neighbor behavior along the wall has no significant effect on individual wall‐following behavior.
Design, Synthesis and Cytotoxic Evaluation of N‐Acylhydrazone‐Incorporated Isoxazolo[4,5‐d]pyridazin‐4(5H)‐one Derivatives
Authors: Ozadali‐Sari Keriman , Ceylan Serenay , Yucel Evnur Sinem , Sabuncuoglu Suna , Unsal‐Tan Oya 
Published: August 2022

AbstractA series of isoxazolo[4,5‐d]pyridazin‐4(5H)‐one hybrids with N‐acylhydrazone structure was prepared and screened for their cytotoxic activities. The in vitro antiproliferative activity of the target molecules was evaluated against a panel of sixty cancer cell lines (NCI‐60) by the National Cancer Institute. Seven of the target compounds showed prominent % inhibition against various cancer cell lines at the one‐dose assay and were subsequently screened for five‐dose assay. 4d, 4e and 4g (full panel mean graph midpoint GI50=9.33, 5.25 and 7.94 μM) emerged as the most promising derivatives against multiple cancer cell lines in comparison with 5‐fluorouracil and gefitinib (full panel mean graph midpoint GI50=18.60 and 3.46 μM). They exhibited remarkable antiproliferative activity with GI50 values submicromolar concentrations against some of the cell lines. The compounds were also found to display mild toxicity to the healthy cells compared to the cancer cell lines indicating safety. Druglikeness and high oral bioavailability were predicted for most of the compounds. As a result, a current study unveiled isoxazolo[4,5‐d]pyridazin‐4(5H)‐ones bearing N‐acylhydrazone as promising anticancer agents with antiproliferative effects.
γ‐Oryzanol concentrations in various rice genotypes ripened under different air temperatures
Authors: Nakano Hiroshi , Yoshida Hiroe , Yabe Shiori , Fushimi Erina , Tanaka Ryo , Yamasaki Masanori , Nakagawa Hiroshi 
Published: August 2022

AbstractBackground and ObjectiveTwo steryl ferulates (γ‐oryzanol), that is, cycloartenyl ferulate and 24‐methylenecycloartanyl ferulate, were previously isolated as biomarkers for heat stress during ripening in rice (Oryza sativa L.). γ‐Oryzanol is also known to exert several biomedical effects, such as antihyperlipidemic, antidiabetic, anti‐inflammatory, and anticancer activities. In the present study, we aimed to determine the effect of air temperature during 1–30, 1–15, and 16–30 days after heading on the concentrations of γ‐oryzanol using 92 rice genotypes.FindingsThe concentration of cycloartenyl ferulate had strong negative correlations with daily maximum air temperatures during 16–30 days after heading. However, the concentrations of 24‐methylenecycloartanyl ferulate and total γ‐oryzanol exhibited strong positive correlations with daily minimum air temperatures during 1–15 days after heading. Moreover, there were strong genotypic differences in the concentrations of these compounds.ConclusionThe concentrations of cycloartenyl ferulate, 24‐methylenecycloartanyl ferulate, and total γ‐oryzanol can be modulated by the selection of cultivars and growing seasons.Significance and NoveltyThis study investigates the concentrations of cycloartenyl ferulate, 24‐methylenecycloartanyl ferulate, and total γ‐oryzanol in 92 rice genotypes ripened under different air temperatures, which provided essential information for the development of rice cultivars and farming methods modulating γ‐oryzanol concentration.
Oxidation of Thiosulphate using TCNQFn (n=0, 2, 4) Derivatives with a Tuneable Driving Force: Electrochemical and Spectrophotometric Detection of a Protonated Intermediate
Authors: Alzubidi Anbrah E. , Bond Alan M. , Martin Lisandra L. 
Published: August 2022

AbstractFluorine substituent effects associated with the
and
(n=0, 2, 4, TCNQ=7,7,8,8‐tetracyanoquinodimethane) half‐cell reactions provide access to a wide driving force range (∼850 mV) which is available to tune redox reactions; in this case the oxidation of
to
by
or
. The
‐
/
redox chemistry was studied by steady‐state and transient cyclic voltammetry and UV‐visible spectrophotometry in acetonitrile containing 5 % water and
as the supporting electrolyte. In this mixed solvent system, all the
(n=0, 2, 4)‐
/
reactions were thermodynamically favourable, as were those of
(n=2, 4). However,
does not oxidize
. These findings lead to a prediction that the reversible potential for the
/
half‐cell reaction lies between −0.083 and −0.278 V vs SHE. Interestingly, in the investigation of the reaction of
and
in a 1 : 2 concentration ratio, a protonated
intermediate was detected. In contrast, when the oxidant was
(2,5‐difluoro‐7,7,8,8‐tetracyanoquinodimethane) or
(2,3,5,6‐tetrafluoro‐7,7,8,8‐tetracyanoquino‐dimethane), no evidence for an analogous protonated intermediate was found. However, if equimolar ratios of
(n=0, 2, 4) and
were used, the intermediate was again detected. The structure of the intermediate, described as
for convenience, is unknown, but this derivative of the redox chemistry is kinetically very stable and only very slowly deprotonated to
or reduced by excess
to give oxidized
and deprotonated
. Mechanisms are provided to explain the formation of the protonated intermediate.
PROTOCOL: Arts‐based interventions for offenders in secure criminal justice settings to improve rehabilitation outcomes: An evidence and gap map
Authors: Tallent Jacqueline , Phillips Jes , Coren Esther 
Published: August 2022

AbstractThis is the protocol for a Campbell evidence and gap map. The objective of this evidence and gap map is to presents the existing research on the impact of arts‐based interventions in secure criminal justice settings (SCJS) that aim to improve desistance outcomes for offenders. It will indicate the quality of available evidence, highlighting the gaps and informing future research priorities. Importantly, it will also identify where the evidence could be systematically reviewed. This would clearly produce a more comprehensive understanding of the available knowledge and an opportunity to move forward in a more direct and focussed way, with the potential to influence research, intervention development, and inform funding decisions.
Bone morphogenetic protein pathway responses and alterations of osteogenesis in metastatic prostate cancers
Authors: Provera Meredith D. , Straign Desiree M. , Karimpour Parvanee , Ihle Claire L. , Owens Philip 
Published: August 2022

AbstractBackgroundProstate cancer is a common cancer in men that annually results in more than 33 000 US deaths. Mortality from prostate cancer is largely from metastatic disease, reflecting on the great strides in the last century of treatments in care for the localized disease. Metastatic castrate resistant prostate cancer (mCRPC) will commonly travel to the bone, creating unique bone pathology that requires nuanced treatments in those sites with surgical, radio and chemotherapeutic interventions. The bone morphogenetic protein (BMP) pathway has been historically studied in the capacity to regulate the osteogenic nature of new bone. New mineralized bone generation is a frequent and common observation in mCRPC and referred to as blastic bone lesions. Less common are bone destructive lesions that are termed lytic.MethodsWe queried the cancer genome atlas (TCGA) prostate cancer databases for the expression of the BMP pathway and found that distinct gene expression of the ligands, soluble antagonists, receptors, and intracellular mediators were altered in localized versus metastatic disease. Human prostate cancer cell lines have an innate ability to promote blastic‐ or lytic‐like bone lesions and we hypothesized that inhibiting BMP signaling in these cell lines would result in a distinct change in osteogenesis gene expression with BMP inhibition.ResultsWe found unique and common changes by comparing these cell lines response and unique BMP pathway alterations. We treated human PCa cell lines with distinct bone pathologic phenotypes with the BMP inhibitor DMH1 and found distinct osteogenesis responses. We analyzed distinct sites of metastatic PCa in the TCGA and found that BMP signaling was selectively altered in commons sites such as lymph node, bone and liver compared to primary tumors.ConclusionsOverall we conclude that BMPs in metastatic prostate cancer are important signals and functional mediators of diverse processes that have potential for individualized precision oncology in mCRPC.
On enhanced estimation and monitoring of population variance using robust auxiliary parameters based estimators
Authors: Yadav Subhash Kumar , Ahmad Shabbir , Riaz Muhammad 
Published: August 2022

SummarySearching for efficient estimators of population variance as compared to sample variance has been the key area of interest of the researchers. Auxiliary variable has helped very much in finding estimators more efficient than sample variance. Auxiliary variable is greatly correlated with main study variable. Many authors including Isaki (J Am Stat Assoc 1983, 78, 117) used positively correlated auxiliary variable in the form of various conventional and non‐conventional auxiliary parameters and suggested different ratio type estimators of population variance. In this article, we have suggested a naïve class of variance estimators based on some robust auxiliary parameters, which deals with the outliers in the data. The properties including bias and Mean Square Error (MSE) of suggested family of estimators are studied up to first order of approximation. The theoretical as well as empirical comparison of introduced family of estimators is carried out with competing variance estimators. The estimator with the least MSE is recommended in different areas of applications. At last, the Shewhart type control charts based on the proposed estimators are also studies for application in quality control.
Iterative detection of CO‐OFDM signals with phase errors using circular random variables
Authors: Rezenom Seare H. , Takawira Fambirai 
Published: August 2022

SummaryWe propose a low‐complexity graph‐based iterative algorithm for the detection of coherent optical OFDM signals in the presence of residual carrier frequency offset and phase noise. We exploit the circular properties of the frequency offset and phase noise and derive graphical messages using the Gaussian probability density function. The proposed algorithm shows similar error rate performance as the existing algorithm at a much lower implementation complexity.
Hybrid optimization for fault‐tolerant and accurate localization in mobility assisted underwater wireless sensor networks
Authors: Nain Mamta , Goyal Nitin , Rani Shikha , Popli Renu , Kansal Isha , Kaur Preet 
Published: August 2022

SummaryMobility prediction and fault tolerance are extremely difficult due to underwater characteristics. Energy drain is one of the major causes for node faults. Hence, in this research article, a hybrid optimization algorithm is developed for fault‐tolerant and accurate localization in UWSN. In this technique, Artificial Butterfly Optimization (ABO) algorithm is applied for finding the distance between the anchors and the sensors. Each non‐localized node runs ABO algorithm for finding the distance amid the anchor or beacon nodes. Then, applying Quaternion‐based Backtracking Search Optimization (QBSA) algorithm, non‐localized sensor nodes are localized and to decrease the localization error based on the Received Signal Strength Indicator (RSSI), battery energy, and distance parameters. Aqua‐Sim a tool kit of NS2 is an open‐source software developed for Underwater Wireless Sensor Network research, and this proposed algorithm will be implemented using this software. By simulation results, it is shown that the proposed optimization algorithm reduces the localization error, latency, and cost and energy consumption.
Typha for paludiculture—Suitable water table and nutrient conditions for potential biomass utilization explored in mesocosm gradient experiments
Authors: Haldan Kerstin , Köhn Nora , Hornig Anja , Wichmann Sabine , Kreyling Jürgen 
Published: August 2022

AbstractDrainage has turned 650,000 km2 of peatlands worldwide into greenhouse gas sources. To counteract climate change, large‐scale rewetting is necessary while agricultural use of rewetted areas, termed paludiculture, is still possible. However, more information is required on the performance of suitable species, such as cattail, in the range of environmental conditions after rewetting. We investigated productivity and biomass quality (morphological traits and tissue chemical composition) of Typha angustifolia and Typha latifolia along gradients of water table depth (−45 to +40 cm) and nutrient addition (3.6–400 kg N ha−1 a−1) in a six‐month mesocosm experiment with an emphasis on their high‐value utilization, e.g., as building material, paper, or biodegradable packaging. Over a wide range of investigated conditions, T. latifolia was more productive than T. angustifolia. Productivity was remarkably tolerant of low nutrient addition, suggesting that long‐term productive paludiculture is possible. Low water tables were beneficial for T. latifolia productivity and high water tables for T. angustifolia biomass quality. Rewetting will likely create a mosaic of different water table depths. Our findings that the yield of T. angustifolia and tissue chemical composition of T. latifolia were largely unaffected by water table depth are therefore promising. Depending on intended utilization, optimal cultivation conditions and preferable species differ. Considering yield or diameter, e.g., for building materials, T. latifolia is generally preferable over T. angustifolia. A low N, P, K content, high Si content and high C/N‐ratio can be beneficial for processing into disposable tableware, charcoal, or building material. For these utilizations, T. angustifolia is preferable at high water tables, and both species should be cultivated at a low nutrient supply. When cellulose and lignin contents are relevant, e.g., for paper and biodegradable packaging, T. angustifolia is preferable at high water tables and both species should be cultivated at nutrient additions of about 20 kg N ha−1 a−1.
Choice of benthic macroinvertebrate‐based metrics for assessing water quality in the littoral zone under anthropogenic disturbance in southern Lake Kivu (East Africa)
Authors: Hyangya Béni Lwikitcha , Kankonda Alidor Busanga , Dusabe Marie‐Claire , Murhimanya Jean‐Diste Kulimushi , Kaningini Boniface Mwenyemali , Masilya Pascal Mulungula 
Published: August 2022

AbstractBenthic macroinvertebrates are widely used to assess the ecological quality of fresh waters. This is because they are in direct contact with the aquatic environment and respond differently to pollutants and changes in the watershed, which are difficult to assess by toxicological or chemical monitoring alone. This study used benthic macroinvertebrate parameters to assess the quality of the nearshore waters of lake Kivu. Twenty‐six metrics covering various aspects of the community were tested using whisker plots to compare their sensitivity in discriminating between reference and disturbed stations. Nine parameters (% EPT taxa, % Diptera taxa, % Chironomid taxa, % Insect taxa; % no Insects taxa, ratio EPT/Chironomid taxa, % moderate tolerant taxa, % very moderate tolerant taxa, Family Biotic Index) were found to be sensitive and were able to discriminate between reference and disturbed stations. All sensitive metrics, with the exception of the percentage of EPT taxa, were positively and/or negatively correlated with the physico‐chemical parameters affected by the changes in the littoral zone. The combined values of the three calculated biotic indices (ASPT, BMWP, and FBI) showed that the biological water quality varies from moderate to good in the reference stations and from average to poor in the disturbed stations. It is concluded that metrics based on benthic macroinvertebrates are effective for assessing water quality in the littoral zone of Lake Kivu in the context of the lack of historical water quality databases and specific tools for toxicological assessment. It is suggested to compare the performance of this approach with others currently used in bio‐indication.