bluuebunny/crossref_metadata_2025_split huggingface dataset:
PERSEPSI DAN TINGKAT SELF-ESTEEM PENGUNJUNG TERHADAP DESAIN ARSITEKTUR LANSEKAP WISATA SIRING TENDEAN
Authors: Hariyono Dyta Setiawati , Aina Noor 
Published: October 2022

ABSTRAK.Siring Tendean is very crowded because of its strategic location in the middle of the city. The quality of public space is a reflection of the quality of city life, where public space is able to influence human activities and behavior. Humans can give a conclusion to what they see, hear and feel and have different perceptions in evaluating physical objects. In the science of architecture, a design has an impact on the views of humans who observe it. In psychology there is what is called Self-Esteem which is a dimension of self-assessment, in the sense of whether a person overall feels good or bad. In this case, can the Siring Tendean landscape design increase visitor self-esteem (feeling better)? This study aims to evaluate the results of the landscape design design of the Siring Tendean tourist attraction from visitors' perceptions of its quality and whether it can affect the level of self-esteem of visitors, so that the research results can be used as input for the creation of environmental design results with better quality in the future. come. This study uses a mix method, namely using qualitative descriptive methods in field observations and visitor interviews, and quantitative methods for perception and self-esteem.Keywords: perception, self-esteem, public space, landscape, Siring Tendean ABSTRAKSiring Tendean ini sangat ramai dikunjungi karena letaknya strategis di tengah kota. Kualitas ruang publik menjadi cerminan dari kualitas kehidupan kota, dimana ruang publik mampu mempengaruhi kegiatan dan perilaku manusia. Manusia dapat memberikan sebuah kesimpulan terhadap apa yang mereka lihat, dengar dan rasakan serta mempunyai persepsi yang berbeda- beda dalam memberikan penilaian pada obyek-obyek fisik. Dalam ilmu arsitektur sebuah desain memberikan dampak terhadap pandangan manusia yang mengamatinya. Dalam ilmu psikologi ada yang disebut Self-Esteem yang merupakan dimensi penilaian terhadap diri sendiri, dalam arti apakah secara keseluruhan seseorang merasa dirinya baik atau buruk. Dalam hal ini apakah desain lansekap Siring Tendean dapat meningkatan self-esteem (merasa diri menjadi lebih baik) pengunjung. Penelitian ini bertujuan untuk mengevaluasi hasil rancangan desain lansekap objek wisata Siring Tendean dari persepsi pengunjung terhadap kualitasnya dan apakah dapat mempengaruhi tingkat self-esteem pengunjungnya, sehingga dari hasil penelitian dapat dipakai sebagai masukan bagi terciptanya hasil rancangan lingkungan dengan kualitas yang lebih baik di masa yang akan datang. Penelitian ini menggunakan mix methode yaitu menggunakan metode deskriptif kualitatif pada observasi lapangan dan wawancara pengunjung, dan metode kuantitatif untuk persepsi dan self-esteem.Kata kunci: persepsi, self-esteem, ruang publik, lansekap, Siring Tendean
Huge cerebral pial arteriovenous fistula in a newborn: illustrative case
Authors: Berestov Vadim , Seleznev Pavel , Obedinskaya Natalya , Korostyshevskaya Alexandra , Gofer Julia , Bondarenko Ilya , Kiselev Roman , Krasilnikov Sergey , Brusyanskaya Anna , Orlov Kirill 
Published: October 2022

BACKGROUND
Pediatric arteriovenous malformations (AVMs) and pial/dural arteriovenous fistulas (AVFs) are rare but life-threatening complications that can lead to congestive heart failure and hemorrhagic stroke in newborns and pediatric patients. The pronounced shunting in these conditions is associated with early complications and necessitates aggressive surgical management. Here, the authors describe endovascular treatment of an atypical cerebral pial AVF in a newborn.

OBSERVATIONS
This AVF formed direct communication between a major cerebral artery (basilar artery) and a large draining vein (dilated deep cerebral vein). The authors performed earlier subtotal embolization of the AVF using 0.020-inch coils, which led to progressive thrombosis of the fistula with restoration of normal arterial blood flow. The patient was discharged 18 days after surgery, examination at 1.5 and 6 months showed magnetic resonance imaging signs of blood flow absence through the fistula and satisfactory condition of the infant without physical and mental developmental delay.

LESSONS
Subtotal coiling of a high-flow pial AVF in a newborn can result in a good clinical outcome.
НЕЧІТКА МОДЕЛЬ ДИСПЕРСНОГО СКЛАДУ ТВЕРДИХ ЧАСТОК ДЛЯ ОЦІНЮВАННЯ ЗАПИЛЕНОСТІ АТМОСФЕРНОГО ПОВІТРЯ
Authors: Божко Костянтин , Морозова Ірина 
Published: October 2022

В роботі розглянуто нечітку модель для оцінювання рівня запиленості атмосферного повітря на основі врахування дисперсного складу твердих часток. Модель побудована за алгоритмом Мамдані. Використано три входи і один вихід, які мають по три функції належності. Вхідні дані є значеннями концентрації твердих часток типу РМ1, РМ2.5 та РМ10. Джерелом вхідних даних є доступні із мережі в реальному часі результати вимірювань станціями екологічного моніторингу (ресурс ECOBOT). Це дозволяє оперативно здійснювати апробацію і, за необхідності, – корекцію моделі не тільки розробнику програми, але і її користувачу (експерту). База нечітких правил компактна і налічує усього 27 формул нечіткого виведення. Модель розроблена в модулі FUZZY LOGIC TOOLBOX пакету MATLAB. Окреме врахування концентрації часток із субмікронним розміром у загальному коефіцієнті запиленості є важливою особливістю моделі і надає їй перевагу перед стандартним оцінюванням, оскільки підвищує увагу експерта до вкрай шкідливого для здоров’я людини чинника забруднення.
Ethnography of Ulur-ulur Tulungagung Ritual and the Disconnected Memory
Authors: Ayuningtyas Fitria , Hakim Luqman 
Published: October 2022

This research aims to elucidate the reason behind the decline of villagers’ enthusiasm toward the Ulur-ulur ritual. Ulur-ulur ritual is a surviving agrarian ritual that was initially an integral part of and executed by four villages, including the Village of Sawo, Ngentrong, Gedangan, and Gamping Tulungagung Regency, as a manifestation of gratitude for the water of Buret Lake sustaining local’s agricultural activity. Historically, this ritual was dying in 1965, then revitalized in 1966 by the Paguyuban Sendang Tirto Mulyo. Currently, despite being set as the annual agenda of Tulungagung Tourism and officially acknowledged as an intangible cultural heritage by the Ministry of Education and Culture of Indonesia in 2020, the villagers' enthusiasm remains low. To uncover this phenomenon, this research employed an ethnographic approach. In-depth interviews and participatory research were executed to obtain data. The result showed that the ritual was constructed and operated by two memories: dhanyangan (ancestral spirit) and agricultural memories. However, the impact of the G-30-S tragedy escalated the tension in the society leading to the vandalism of the Sri-Sedono statues, which were the mnemonic device of agricultural memory. Meanwhile, the dhanyangan memory, constantly amplifying, created a clash with the more religious society’s narrative. The long vacuum period and the narrative shift make the association of ritual with the dhanyangan grow more robust, which contradicts the current social context. Furthermore, the revitalization, which was merely rooted in “defeated memory” led to the exclusion of the ritual from society.
A Comparative Study of Serum Amyloid A2 with Anti-cyclic Citrullinated Peptide antibody in the prognosis of a Group of Rheumatoid Arthritis Patients in Iraq
Authors: Abdulameer Ali , I. Abid Mohammed Khalil , H. Alosami Mohammed 
Published: October 2022

Abstract:
Background: Rheumatoid arthritis (RA) is an inflammatory disease of unknown etiology characterized by joint inflammation and the presence of autoantibodies, mostly Anti-cyclic citrullinated peptide antibody (ACCP) which are released when the body loses its ability to distinguish between self and foreign molecules. Serum amyloid A2 (SAA2) is an acute phase protein produced in response to inflammatory conditions including RA.
Objectives: To investigate the prognostic ability of SAA2 in comparison with ACCP and the prediction of disease activity and response to treatment by Methotrexate and Etanercept in Iraqi RA patients.
Patients and methods: A case control study, on a total of 150 individuals; 100 patients and 50 healthy controls. The study was carried out between November 2021 to February 2022 in Baghdad Teaching Hospital. The patients were recruited according to the American College of Rheumatology 2010 criteria. The biomarkers’ levels were measured by enzyme-linked immunosorbent assay.
Results: The levels of ACCP and SAA2 in RA patients were significantly higher compared to healthy controls (p<0.001), and were higher among patients with active disease than those with inactive disease, with the levels being higher in both categories than the healthy controls (p<0.00). Highly significant ACCP levels were found in patients without treatment than those who have received treatment (methotrexate or etanercept) (p<0.00). SAA2 level in patients without treatment were not significantly different from those of patients who have received methotrexate (p>0.05) but significantly from those who have received etanercept (p≤0.02). A significant positive correlation was found between ACCP and SAA2 (r=0.553, p<0.001), with the sensitivity being (72%, 97%) and the specificity being (98%, 84%) respectively.
Conclusion: ACCP and SAA2 have promising prognostic ability and disease activity prediction of RA with response to treatment (Methotrexate, Etanercept).
Efektivitas Cuka Apel (Apple Cider Vinegar) Sebagai Bahan Alami Bleaching Pada Gigi Yang Mengalami Diskolorasi Ekstrinsik
Authors: Mattulada Indrya Kirana , Asmah Nur , Aslan Sarahfin , Arifin Fadil Abdillah , Setiawan Putri Agung 
Published: October 2022

Pendahuluan: Gigi yang putih merupakan salah satu hal yang diidamkan masyarakat untuk menunjang penampilan sehingga seseorang dapat memiliki kepercayaan diri yang tinggi ketika berinteraksi. Stain tidak dapat hilang dengan menyikat gigi saja, penggunaan bahan alami dalam memutihkan gigi sangat berkembangi di imasyarakat dan banyak dilakukan penelitian karena bahan alami dianggap lebih aman, murah dan mudah diperoleh bilai dibandingkan dengan bahan kimia. Tujuan Penelitian: Tujuan dilakukan penelitian ini untuk mengetahui apakah cuka apel efektif sebagai bahan alami bleaching pada gigi yang mengalami diskolorasi ekstrinsik. Bahan dan Metode: Bahan pada penelitian adalah cuka apel anna konsentrasi 10%, karbamid peroksida konsentrasi 10% serta 16 buah gigi insisivus rahang atas terdiri dari 2 perlakuan yaitu perendaman larutan cuka apel anna 10% dan pengaplikasian gel karbamid peroksida 10%. Metode penelitian ini adalah kualitatif dengan jenis penelitianTrue Expermintal Laboratorium yang bertujuan untuk mengetahui suatu gejala atau pengaruh yang timbul akibat adanya perlakuan tertentu. Rancangan penelitian ini adalah pre-testiipost-test with control group design, penelitian diawali dengan perendaman kopi (diskolorasi) selama 5 hari kemudian diberi perlakuan selama 12 hari, pada hari ke 5, hari ke 10 dan hari ke 12 dilakukan pengambilan gambar pada seluruh sampel penelitian. Hasil : Hasil Penelitian ini menunjukkan hasil uji beda didapatkan nilai p-value 0,872 sehingga dapat diasumsikan bahwa cuka apel 10% dan karbamid peroksida 10% tidak memiliki perbedaan yang signifikan dalam mencerahkan gigi yang terdiskolorasi akibat kopi. Pada hasil pengukuran perubahan warna pada kelompok cuka apel 10% dan karbamid peroksida 10% berdasarkan Uji Statistik Independent T-Test diperoleh nilai 0,009 dan 0,006 yaitu signifikan dapat mencerahkan. Namun karbamid peroksida 10% memiliki efektivitas yang lebih baik. Kesimpulan: berdasrkan hasil penelitian ini menunjukkan bahwa larutan cuka apel 10% memiliki efektivitas untuk mencerahkan gigi yang mengalami diskolorasi ekstrinsik akibat kopi.
Comparison of the biomechanical differences in the occlusal movement of wild-type and BMP9 knockout mice with apical periodontitis
Authors: Peng Mengtian , Ma Xiaofei , Cao Yuying , Wang Chunjuan , Tan Qin , Chu Xinyue , Zhou Pengfei , Fu Tiwei , Liang Panpan , Ran Shidian , He Tong-Chuan , Wang Jinhua , Huang Enyi 
Published: October 2022

Apical periodontitis is a common clinical disease caused by bacteria; bacterial metabolites can cause an imbalance in bone homeostasis, bone mass reduction, and tooth loss. Bone resorption in apical periodontitis causes a concentration of stress in the tooth and periodontal tissues during occlusion, which aggravates the disease. Emerging evidence indicates that bone morphogenetic protein 9 (BMP9), also known as growth differentiation factor 2(Gdf2), may play an important role in tooth and dentoalveolar development. Herein, we investigated the role of BMP9 in the development of apical periodontitis and its effects on the biomechanics of dentoalveolar bone. Apical periodontitis models were established in five BMP9 knockout (KO) mice and five C57BL/6 WT (wild-type) mice. At baseline and 14, 28, and 42 days after modeling, in vivo micro-computed tomography analysis and three-dimensional (3D) reconstruction were performed to evaluate the apical lesion in each mouse, and confirm that the animal models were successfully established. Finite element analysis (FEA) was performed to study the stress and strain at the alveolar fossa of each mouse under the same vertical and lateral stress. FEA revealed that the stress and strain at the alveolar fossa of each mouse gradually concentrated on the tooth cervix. The stress and strain at the tooth cervix gradually increased with time but were decreased at day 42. Under the same lingual loading, the maximum differences of the stress and strain at the tooth root in KO mice were greater than those in WT mice. Thus, these findings demonstrate that BMP9 could affect the biomechanical response of the alveolar fossa at the tooth root in mice with apical periodontitis. Moreover, the effects of BMP9 on the biomechanical response of the alveolar bone may be site-dependent. Overall, this work contributes to an improved understanding of the pathogenesis of apical periodontitis and may inform the development of new treatment strategies for apical periodontitis.
Enhanced small green fluorescent proteins as a multisensing platform for biosensor development
Authors: Liang Guo-Teng , Lai Cuixin , Yue Zejun , Zhang Hanbin , Li Danyang , Chen Zhong , Lu Xingyu , Tao Liang , Subach Fedor V. , Piatkevich Kiryl D. 
Published: October 2022

Engineered light, oxygen, and voltage (LOV)-based proteins are able to fluoresce without oxygen requirement due to the autocatalytic incorporation of exogenous flavin as a chromophore thus allowing for live cell imaging under hypoxic and anaerobic conditions. They were also discovered to have high sensitivity to transition metal ions and physiological flavin derivatives. These properties make flavin-binding fluorescent proteins (FPs) a perspective platform for biosensor development. However, brightness of currently available flavin-binding FPs is limited compared to GFP-like FPs creating a need for their further enhancement and optimization. In this study, we applied a directed molecular evolution approach to develop a pair of flavin-binding FPs, named miniGFP1 and miniGFP2. The miniGFP proteins are characterized by cyan-green fluorescence with excitation/emission maxima at 450/499 nm and a molecular size of ∼13 kDa. We carried out systematic benchmarking of miniGFPs in Escherichia coli and cultured mammalian cells against spectrally similar FPs including GFP-like FP, bilirubin-binding FP, and bright flavin-binding FPs. The miniGFPs proteins exhibited improved photochemical properties compared to other flavin-binding FPs enabling long-term live cell imaging. We demonstrated the utility of miniGFPs for live cell imaging in bacterial culture under anaerobic conditions and in CHO cells under hypoxia. The miniGFPs’ fluorescence was highly sensitive to Cu(II) ions in solution with Kd values of 67 and 68 nM for miniGFP1 and miniGFP2, respectively. We also observed fluorescence quenching of miniGFPs by the reduced form of Cu(I) suggesting its potential application as an optical indicator for Cu(I) and Cu(II). In addition, miniGFPs showed the ability to selectively bind exogenous flavin mononucleotide demonstrating a potential for utilization as a selective fluorescent flavin indicator. Altogether, miniGFPs can serve as a multisensing platform for fluorescence biosensor development for in vitro and in-cell applications.
Cardiovascular and hepatic disease associations by magnetic resonance imaging: A retrospective cohort study
Authors: Kwan Alan C. , Sun Nancy , Driver Matthew , Botting Patrick , Navarrette Jesse , Ouyang David , Hussain Shehnaz K. , Noureddin Mazen , Li Debiao , Ebinger Joseph E. , Berman Daniel S. , Cheng Susan 
Published: October 2022

BackgroundHepatic disease is linked to cardiovascular events but the independent association between hepatic and cardiovascular disease remains unclear, given shared risk factors.MethodsThis was a retrospective study of consecutive patients with a clinical cardiac MRI (CMR) and a serological marker of hepatic fibrosis, the FIB-4 score, within one year of clinical imaging. We assessed the relations between FIB-4 scores grouped based on prior literature: low (&lt; 1.3), moderate (1.3–3.25), and high (&gt;3.25), and abnormalities detected by comprehensive CMR grouped into 4 domains: cardiac structure (end diastolic volumes, atrial dimensions, wall thickness); cardiac function (ejection fractions, wall motion abnormalities, cardiac output); vascular structure (ascending aortic and pulmonary arterial sizes); and cardiac composition (late gadolinium enhancement, T1 and T2 times). We used Poisson regression to examine the association between the conventionally defined FIB-4 category (low &lt;1.3, moderate 1.3–3.25, and high &gt;3.25) and any CMR abnormality while adjusting for demographics and traditional cardiovascular risk factors.ResultsOf the 1668 patients studied (mean age: 55.971 ± 7.28, 901 [54%] male), 85.9% had ≥1 cardiac abnormality with increasing prevalence seen within the low (82.0%) to moderate (88.8%) to high (92.3%) FIB-4 categories. Multivariable analyses demonstrated the presence of any cardiac abnormality was significantly associated with having a high-range FIB-4 (prevalence ratio 1.07, 95% CI: 1.01–1.13); notably, the presence of functional cardiac abnormalities were associated with being in the high FIB-4 range (1.41, 1.21–1.65) and any vascular abnormalities with being in the moderate FIB-4 range (1.22, 1.01–1.47).ConclusionsElevated FIB-4 was associated with cardiac functional and vascular abnormalities even after adjustment for shared risk factors in a cohort of patients with clinically referred CMR. These CMR findings indicate that cardiovascular abnormalities exist in the presence of subclinical hepatic fibrosis, irrespective of shared risk factors, underscoring the need for further studies of the heart-liver axis.
Congenitally corrected transposition with left ventricular outflow obstruction and cardiac malposition: One-and-a-half ventricular repair vs. Fontan pathway?
Authors: Liu Rui , Pang Kunjing , Rui Lu , Zhang Benqing , Wang Chao , Li Shoujun 
Published: October 2022

ObjectivesThis study was to assess the mid-term results of the one-and-a-half ventricular repair (hemi-Mustard and bidirectional Glenn procedures combined with the Rastelli procedure) and Fontan pathway for correcting congenitally corrected transposition of great artery (ccTGA) patients with left ventricular outflow tract obstruction (LVOTO) and cardiac malposition.MethodsIn this retrospective study, 74 consecutive ccTGA with LVOTO and cardiac malposition underwent the one-and-a-half ventricular repair (group A; 33 cases) and Fontan operation (group B; 41 cases) between October 2011 and March 2018. The Median follow-up time was 49 (20–84) and 42 (7–85) months in groups A and B, respectively. To estimate excise tolerance the 6-min walk test (MWT) was performed.ResultsNo in-hospital death. Compared with group A, group B have significantly less CPB, mechanical ventilation time, and intensive care unit stay, but prolonged pleural effusions developed more frequently in Group B. The survival probability was 90.2% (95% CI, 80.2–100%) and 97.2% (95% CI, 92–100%) at 7 years (p = 0.300) in group A and B. The probability of freedom from re-intervention were 80.6% (95% CI, 66.5–97.6%) and 97.2% (95% CI, 92–100%) at 7 years (p = 0.110). Longitudinal repeated measured echo data at every follow-up time shows that group A has more systemic ventricular EF% (p &lt; 0.001) and less moderate systemic ventricular valve regurgitation (p &lt; 0.001) compared with group B. Estimated by 6 MWT, group A has better outcomes for 6-min walk distance.ConclusionsFor correction of ccTGA with LVOTO and cardiac malposition, the one-and-a-half ventricular repair had superior midterm heart function and excise tolerance.
Correlation of left ventricular myocardial work indices with invasive measurement of stroke work in patients with advanced heart failure
Authors: Landra Federico , Mandoli Giulia Elena , Chiantini Benedetta , Barilli Maria , Merello Giacomo , De Carli Giuseppe , Sciaccaluga Carlotta , Lisi Matteo , Flamigni Filippo , D’Ascenzi Flavio , Focardi Marta , Fineschi Massimo , Iadanza Alessandro , Bernazzali Sonia , Maccherini Massimo , Valente Serafina , Cameli Matteo 
Published: October 2022

ObjectivesThis study aimed to explore the correlation between left ventricular (LV) myocardial work (MW) indices and invasively-derived LV stroke work index (SWI) in a cohort of patients with advanced heart failure (AHF) considered for heart transplantation.BackgroundLeft ventricular MW has emerged as a promising tool for diagnostic and prognostic purposes in heart failure (HF) but its relationship with hemodynamic data derived from right heart catheterization (RHC) has not been assessed in patients with advanced heart failure yet.Materials and methodsConsecutive patients with AHF considered for heart transplantation from 2016 to 2021 performing RHC and echocardiography as part of the workup were included. Conventional LV functional parameters and LV MW indices, including LV global work index (GWI), LV global constructive work (GCW), LV global wasted work (GWW), LV global work efficiency (GWE), and other were calculated and compared with invasively-measured LV SWI.ResultsThe population included 44 patients. Median time between RHC and echocardiography was 0 days (IQR: 0–24). Median age was 60 years (IQR: 54–63). For the most part, etiology of HF was non-ischemic (61.4%) and all patients were either on class NYHA II (61.4%) or III (27.3%). Median left ventricular ejection fraction was 25% (IQR: 22.3–32.3), median NT-proBNP 1,377 pg/ml (IQR: 646–2570). LV global longitudinal strain (GLS) significantly correlated with LV SWI (r = –0.337; p = 0.031), whereas, LV ejection fraction (EF) did not (r = 0.308; p = 0.050). With regard to LV MW indices, some of them demonstrated correlation with LV SWI, particularly LV GWI (r = 0.425; p = 0.006), LV GCW (r = 0.506; p = 0.001), LV global positive work (LV GPW; r = 0.464; p = 0.003) and LV global systolic constructive work (GSCW; r = 0.471; p = 0.002).ConclusionAmong LV MW indices, LV GCW correlated better with invasively-derived SWI, potentially representing a powerful tool for a more comprehensive evaluation of myocardial function.