THE COMPARATIVE EVALUATION OF PERMETRIN-BASED DRUGS FOR ECTOPARASITOSIS OF DOGS AND CATS
Authors: Tishyn O. L. , Yuskiv I. D. , Stetsko T. I. , Perih Zn. M. , Bogach O. M. 
Published: January 2022

The article presents data about effectiveness of the new domestic antiparasitic drug «Antiparasitic Spray Fipromax» in comparison to the reference drug «Permethrin» when used for therapeutic and prophylactic purposes for ectoparasitosis of dogs and cats of different breeds.
According to the results of studies at 8 hours after usage of the experimental drug «Antiparasitic Spray Fipromax» its effectiveness for syphanopterosis in dogs was 88.8 %, and after usage of the reference drug «Permethrin» its effectiveness for syphonapterosis in dogs was 87.3 %. In experiments on cats, it was found that at 8 hours after usage of the experimental drug, its effectiveness for syphonapterosis of cats was 88.1 %, and after usage of the reference drug – 85.3 %. From the first and third days after the application of drugs on fur of dogs and cats of the experimental and control groups, parasitological studies did not reveal fleas of the species Ctenocephalus canis, Ctenocephalus felis and Pulex irritans. Thus, presented for research drugs «Antiparasitic Spray Fipromax» and «Permethrin» in dogs and cats showed 100 % effectiveness during the siphonapterose invasion.
After usage of the experimental drug, intensity of the trichodectosis invasion in dogs in this group decreased for 1 day from 18.8 ± 2.34 to 1.5 ± 0.22 specimens/100 cm², and after usage of the reference drug also decreased in the control group from 19.3 ± 2,81 to 2.0 ± 0.37 specimens/100 cm² of body surface. It means that the effectiveness of the drug «Antiparasitic Spray Fipromax» for the trichodectosis invasion of dogs was 92.0 %, and the reference drug «Permethrin» – 89.7 %. on the 1st day after application. At entomological examination on 2 and 7 days after treatment of animals, live imago-hair follicles were not detected, so the drugs showed 100 % effectiveness.
During the determination of drug effectiveness for disinfection of open-air aviaries, it was found that before usage, the average intensity of flea invasion in quarters ranged from 13.3 ± 1.15 to 14.2 ± 1.08 specimens/m2 of surface. After disinfection of aviary with the experimental drug, the average intensity of invasion after 8 hours was 1.3 ± 0.33 specimens/m2, and after treating with the reference drug – 2.8 ± 0.40 specimens/m2 of the surface and after 24 and 72 hours no fleas were found in quarter.
According to the results of determination of insecticidal and acaricidal activity in vitro in the concentration recommended by the manufacturer, it was found that direct aerosol spraying of the drug «Antiparasitic Spray Fipromax» on wingless insects-ectoparasites and Ixodes mites of different stages of development (imago, nymphs) for 10 and 30-minute exposure, caused to their destruction, respectively.
Studies have shown that for exodidosis of dogs at 8 hours after usage of the experimental drug, its effectiveness was 89.0 %, and after usage of the reference drug – 85.3 %. As early as the 24th hour of the experiment, no Ixodes ricinus and Dermacentor reticulatus ticks were detected on the skin of dogs. Therefore, usage of the studied drugs in ixodidosis invasion of animals showed 100 % efficiency.