bluuebunny/crossref_metadata_2025_split huggingface dataset:
Un bison en Provence : l’abri du bison à Ségriès, Moustiers Sainte-Marie (Alpes-de-Haute-Provence)
Authors: Paillet Eléna , Paillet Patrick , Konik Stéphane 
Published: April 2022

L’abri du bison de Ségriès constitue l’un des rares témoignages d’art préhistorique dans la région Provence-Alpes-Côte d’Azur. Au moment de sa découverte, dans les années 1960, la grotte Cosquer n’était pas encore connue et ce site était donc le seul à pouvoir revendiquer l’existence d’un art pariétal paléolithique dans la région. Il est cependant longtemps resté ignoré de la communauté scientifique, écarté de la plupart des grandes synthèses sur le sujet, autant par méconnaissance que par méfiance. En effet, l’existence d’une gravure isolée, dans une zone relativement reculée des Alpes-de-Haute-Provence, avait de quoi provoquer des doutes. L’étude réalisée à la fin des années 1960 par H. de Lumley (de Lumley 1968) était cependant venue suggérer l’authenticité de cette gravure, au parcours décidément singulier. À la faveur d’une expertise conduite en 2013 par le Centre National de Préhistoire sur la demande du Parc naturel des Gorges du Verdon et du Service Régional de l’Archéologie de la DRAC Provence-Alpes Côte d’Azur, nous avions été amenés à revoir cette gravure et à alerter sur l’état inquiétant de sa conservation. Par la suite, une opération de relevé d’art rupestre, autorisée et financée par l’État (DRAC Paca- Service régional de l’Archéologie) a permis de documenter au mieux son état de conservation et de revenir sur la question de son authenticité.
Le Mané Lud en mouvement. Déroulé de signes dans un ouvrage néolithique de pierres dressées à Locmariaquer (Morbihan)
Authors: Cassen Serge 
Published: April 2022

L’étude menée sur les orthostates enregistrés dans la tombe à couloir du Mané Lud montre qu’ils sont très probablement les ultimes témoins d’un ouvrage de pierres dressées qui, peut-être, accompagnait la ciste enfouie sous le tumulus plus ancien à l’extrémité duquel s’est adossé le dolmen daté des débuts du IVe millénaire. Les dimensions homogènes des dalles et la réalisation technique comparable des gravures sur leurs faces visibles s’ajoutent à une remarquable convergence des signes pour conclure, sans risque majeur, à l’existence d’un ensemble architectural cohérent (barre rectiligne ou barre curviligne de stèles).Si chaque signe fait partie intégrante d’un projet sémiotique, seule une lecture simultanée des signes complémentaires et concurrents gravés sur un même support permet d’en restituer le programme iconographique. Pour cela, les articulations entre les signes, qui font que ceux-ci s’affrontent ou se séparent, se complètent ou se divisent, ont été mesurées et analysées. À l’intervalle « linguistique » évalué entre chaque signe s’est ajouté l’intervalle entre chaque pierre dressée qu’il nous appartenait alors de replacer dans un ordre hypothétique de reconnaissance. Ce rangement s’est opéré en prenant appui sur les formes de la météorisation lisibles sur le granite des pierres, puis sur le sens des déplacements restitué par une lecture dynamique des signes (proue d’un bateau, parties actives des armes, etc.). Le Mané Lud en mouvement devient pour l’archéologue une analyse du déplacement, mais plus fondamentalement encore la description probable de voyages « utopiques » participant à l’explication du monde néolithique. Afin d’expliciter l’intitulé, on montrera en quoi ces assemblages de signes néolithiques sont un monde en réduction, un monde approprié qu’il a fallu ensuite animer ; de là sera portée une réflexion générale sur le pouvoir de la représentation qui prolongera la portée épistémologique du Mané Lud en images en concluant notre projet.
Les modèles biologiques sont-ils utiles pour penser l’évolution des sociétés ?
Authors: Testart Alain 
Published: April 2022

L’article se veut une critique systématique de quelques tentatives de transposition (Luca Cavalli-Sforza, Pascal Jouxtel) du modèle « néo-darwinien » aux faits sociaux ou culturels. Sa thèse principale est que l’explication darwinienne n’est épistémologiquement valide que moyennant certaines conditions assez restrictives : les variations doivent être engendrées 1° indépendamment de leur valeur adaptative, 2° selon une large gamme de variations et 3° de façon aléatoire (du moins, sans prévisibilé). Sinon ce serait ce processus d’engendrement qui déterminerait l’essentiel de l’évolution, et la sélection naturelle n’aurait plus qu’un rôle modique à jouer. Les mutations génétiques obéissent à ces conditions, ce qui fait du modèle darwinien un bon modèle pour penser l’évolution biologique. Mais les innovations sociales n’obéissent à aucune d’entre elles, ce qui rend la transposition au monde social absurde. La suite de l’article met en évidence quelques particularités de l’évolution des sociétés, très différentes de l’évolution des espèces.
Le financement basé sur les résultats (FBR) en Afrique
Authors: Paul Elisabeth , Ridde Valéry 
Published: April 2022

Le financement basé sur les résultats (FBR) dans le secteur de la santé est un modèle voyageur. En dépit de premiers écrits positifs, les preuves de son efficacité se sont érodées. En 2018, un article critique du FBR a suscité des réactions individuelles et collectives parfois virulentes. Nous analysons cette controverse à l’aide d’une analyse qualitative de ces discours. Il en ressort qu’aucun questionnement fondamental de l’approche du FBR n’est proposé par ses promoteurs, qui ne remettent pas en cause le fondement de leur modèle, mais son voyage. Cette controverse illustre l’importance des acteurs et de leurs réseaux dans la construction sociale de la réputation d’un modèle voyageur. Une fois forgée – même sans preuve –, il est difficile de la remettre en question.
A gigantic vertical zoo
Authors: FITZGERALD Des 
Published: April 2022

Why is it that when we see images of major new urban developments today – whether housing units, office blocks, or shopping malls – those developments are as likely as not to be covered in a thin canopy of trees? In this paper, I approach this question by thinking about the long history of the idea that cities are somehow bad for human beings, and especially that they are bad for our mental health. From Shanghai to Paris, from Biophilia to “cheap nature”, from Donna Haraway to Thomas Heatherwick, I examine the growing entanglement between the psychologically restorative city and the green city. I ask: what does it mean, for historical cultures of both madness and the city, that we now ask our urban spaces, recast as centres of nature and biological life, to have even a reparative relationship to mental health?
Methyl gallate isolated from Mangifera pajang kernel induces proliferation inhibition and apoptosis in MCF-7 breast cancer cells via oxidative stress
Authors: Yazan Ranneh , Fadzelly Abu Bakar Mohd , Azlen-Che Rahim , Kartinee Kassim Nur , Johnson Stanslas , Yuan-Han Teh , Abdulmannan Fadel , Mohammed S Ellulu 
Published: April 2022

Objective:
To determine the lead bioactive compound in kernel extract of Mangifera pajang and its anti-cancer activity against human breast cancer cell lines with positive estrogen receptor (MCF-7).

Methods:
The methanolic extract of dried powder kernel of Mangifera pajang was exposed to column chromatography for isolation. The structural elucidation of the isolated compound was characterized using infrared, nuclear magnetic resonance, mass spectrometry. Furthermore, cytotoxicity, morphological changes, flow cytometry and cell cycle arrest analyses were performed to examine the mechanism of anti-proliferation and apoptosis induced by methyl gallate against MCF-7.

Results:
One compound was isolated from the methanolic extract of Mangifera pajang kernel and identified as methyl gallate. The flow cytometric results demonstrated induction of apoptosis in MCF-7 cells by three concentrations of methyl gallate. The cell cycle arrest showed a significant (P<0.05) decrease in cell progression at G2/M phase of MCF-7 after treatment with 100 μM of methyl gallate. The cell percentage of early and late apoptosis was significant at 10 and 100 μM of methyl gallate. Also, methyl gallate treatment induced up-regulation of reactive oxygen species levels in MCF-7 cells with a reduction in superoxide dismutase levels.

Conclusions:
These findings indicate that isolated methyl gallate from Mangifera pajang kernel extracts induces growth inhibition and apoptosis in MCF-7 cells via up-regulating oxidative stress pathway.
Outcome of COVID-19 in Indian patients with cancer
Authors: Seshachalam* Arun , Saju* S. V. , Raju Honey Susan , Rathnam Krishnakumar , Janarthinakani Murugesan , Prasad Krishna , Patil Channappa , Anoop Parameswaran , Reddy Neelesh , Anumula Satish Kumar , Golamari Krishna Reddy , Bodepudi Sravan Kumar , Danthala Madhav , Malipatil Basawantrao , Senthilkumar G , Niraimathi Kesavan , Raman S. G. 
Published: April 2022

Background:
Managing patients with cancer during the coronavirus disease 2019 (COVID-19) pandemic has been challenging. Disruptions in cancer management have been observed due to cancellation of treatment, issues related to commuting, and dearth of health-care workers.

Objectives:
This study was conducted during the first wave of the COVID-19 pandemic and was aimed at evaluating the 30-day all-cause mortality among patients with cancer and COVID-19 infection and the factors affecting it.

Materials and Methods:
In this retrospective study, we collected secondary data from nine tertiary care centers in South India over a period of 10 months from March to Dec 2020. Patients across all age groups with histopathologically confirmed diagnosis of cancer who were affected by COVID-19 during their evaluation or treatment were included in the study. The primary outcome variables of the present study were 30-day all-cause mortality, cancer outcomes, and COVID-19 outcomes.

Results:
A total of 206 patients were included. Median age of the cohort was 55.5 years, and the male-to-female ratio was 1:1.03. The 30-day mortality rate was 12.6%. Twenty-two patients (10.7%) had severe COVID-19 infection at the initial presentation. Predictors for severe pneumonia at the initial presentation were incomplete remission at the time of COVID-19 diagnosis and palliative intent of treatment. Severe pneumonia at the initial presentation, diagnosis of COVID-19 on or before August 2020, and need for ventilator support were associated with increased mortality.

Conclusion:
Severity of infection at the initial presentation, cancer status, and the intent of cancer treatment impact COVID-19 outcomes in patients with cancer.
Significance of too-small-to-characteriz (TSTC) pulmonary nodules in known extrapulmonary solid tumors
Authors: Mahajan* Abhishek , Monachen Matthew , Shukla Shreya , Agarwal Ujjwal , Sable Nilesh , Prabhash Kumar , Rane Swapnil , Thakur Meenakshi 
Published: April 2022

Background:
Increased use of chest computed tomography (CT) scanning and greater awareness among general radiologists has led to a rise in lung nodule identification. Nodules less than 1 cm in diameter are considered small, and the morphology of such nodules is difficult to characterize.

Objectives:
The aim of our study was to determine the significance of pulmonary nodules that are too-small-to-characterize on CT scan in patients with extrapulmonary solid tumors and to determine the characteristics that help in distinguishing malignant from benign pulmonary nodules.

Materials and Methods:
We conducted a retrospective observational study in the Department of Radiodiagnosis of the Tata Memorial Hospital, Mumbai, India, and included patients with non-pulmonary solid malignancies who had obtained baseline CT/positron emission tomography (PET) scans between January 2010 and December 2014. Demographic information, site of the primary tumor, and histological diagnosis were recorded. Baseline and follow-up CT images were read by two radiologists. The significance of associated risk factors was analyzed using Pearson's Chi-square test. A multivariable logistic regression model was used.

Results:
Our study included 200 patients and 334 nodules, of which 148 (44.3%) nodules were found to be benign and 127 (38%) were malignant. The remaining 59 (17.7%) nodules in 32 patients were indeterminate. Most nodules located at a distance of less than 10 mm from the pleura were benign, whereas more than 2/3rd of the nodules more than 10 mm away from the pleura were malignant (n = 60/94, 63.8% P = 0.0001). The mean size of the 148 benign nodules (5.3 mm) was smaller than that of the 127 malignant nodules (9.2 mm). Nearly 93% of malignant nodules were solid (P = 0.0001). About 83% of malignant nodules were round, while 7 of 10 linear-shaped nodules were either benign or indeterminate (P = 0.006). Among the nodules associated with poorly differentiated primary neoplasms, 63.6% were malignant, 25% were benign, and 11.4% were indeterminate (P = 0.005).

Conclusions:
Too-small-to-characterize pulmonary nodules detected on CT are a common clinical problem and are more likely to be benign or indeterminate even in patients with known extrapulmonary neoplasms. Using nodule size, distance from the pleura, and morphological pointers, radiologists can help clinicians decide whether there is a need for biopsy or a short-interval follow-up. We have proposed a Pulmonary Metastases Cancer Imaging and Reporting Data System (PM-CI-RADS).
KADINLARIN TAMAMLAYICI ALTERNATİF TEDAVİYE YÖNELİK TUTUMLARININ COVİD-19 KORKUSUYLA İLİŞKİSİ
Authors: ÜNVER Hacer , IŞIK Kevser , ÜNVER Zeynep 
Published: April 2022

Amaç: Bu araştırma kadınların tamamlayıcı alternatif tedaviye yönelik tutumlarının COVID-19 korkusuyla ilişkisini belirlemek amacıyla yapıldı.
Yöntem: Tanımlayıcı kesitsel tipte yapılan araştırma 572 kadın ile yapıldı. Veri toplamada kişisel bilgi formu, COVID-19 Korkusu Ölçeği, Bütüncül Tamamlayıcı ve Alternatif Tıbba Karşı Tutum Ölçeği kullanıldı.
Bulgular: Araştırmaya katılan kadınların yaş ortalamasının 24.84±7.72 olduğu, %70.6’sının tamamlayıcı alternatif tedavi (TAT) hakkında bilgisinin olduğu, %59.3’ünün bu tedaviyi kısmen güvenli bulduğu, %63.8’inin tamamlayıcı alternatif tedaviyi kullanmadığı, bu tedavi yöntemini kullananların %59.4’ünün bitki çayları içtiği, %41.8’inin vücut direncini arttırmak için TAT kullandığı belirlendi. COVID-19 korku ve tamamlayıcı alternatif tedaviye karşı tutum puan ortalamalarının orta düzeyde olduğu, COVID-19 korkusu ile tamamlayıcı alternatif tedavi tutumu arasında negatif yönde anlamlı bir ilişki olduğu saptandı.
Sonuçlar ve Öneriler: Araştırmada eğitim düzeyi, medeni durum, kronik hastalık, COVID-19 geçirme, tamamlayıcı alternatif tedaviyi güvenli bulma gibi değişkenlerin alternatif tedaviyi kullanımı etkilediği belirlendi. Salgın hastalık durumlarında tamamlayıcı alternatif tedavi yöntemlerinin kullanımına dikkat edilmesi ve sağlık profesyonellerinden bilgi alınması önerilmektedir.
Upaya Guru Pendidikan Agama Kristen Dalam Pembentukan Karakter Remaja Di Masa Pandemi Covid-19
Authors: Nainupu Astrid Maryam Yvonny , Darmawan I Putu Ayub 
Published: April 2022

The Covid-19 Pandemic period hit Indonesia and affected the learning system in schools. Schools should run distance education. This makes it difficult for teachers in schools, including Christian Religious Education Teachers, to educate children so that their character is formed. The focus of this paper is the efforts of Christian Religious Education Teachers to shape the character of teenagers during the Covid-19 pandemic. The writing uses library research methods and Bible interpretation to provide ideas about efforts to build the character of teenagers during the pandemic. These efforts include making a teaching curriculum based on Bible teaching both doctrinally and practically, which focuses explicitly on the fruit of the Spirit in this discussion. Then apply creative learning methods based on information technology. Teachers can also take an enthusiastic approach to teenagers and become trusted friends simultaneously and guide them based on the truth of God's Word. Teachers also establish communication and provide parenting classes for parents so that parents also have the provision to shape the character of Christ in their children.AbstrakMasa Pandemi Covid-19 yang melanda Indonesia dan memengaruhi sistem pembelajaran di sekolah. Sekolah harus menjalankan pendidikan jarak jauh. Hal ini menyulitkan para guru di sekolah, termasuk guru Pendidikan Agama Kristen yang tugasnya mendidik anak-anak agar karakter mereka dibentuk. Fokus dari penulisan ini adalah usaha guru Pendidikan Agama Kristen untuk membentuk karakter anak remaja di masa pandemi Covid-19. Penulisan menggunakan metode penelitian pustaka sehingga dapat memberikan gagasan tentang upaya pembentukan karakter anak remaja tetap dapat dilakukan di masa pandemi. Usaha itu antara lain membuat kurikulum pengajaran yang berdasarkan pada pengajaran Alkitab baik secara doktrinal dan praktika yang secara khusus dalam pembahasan penulisan ini berfokus pada buah Roh. Kemudian menerapkan metode pembelajaran yang kreatif yang berbasis teknologi informasi. Guru juga dapat melakukan pendekatan secara intens kepada anak remaja dan menjadi sahabat yang dapat dipercaya sekaligus serta dapat membimbing mereka berdasarkan kebenaran Firman Tuhan. Guru juga menjalin komunikasi dan menyediakan kelas-kelas parenting bagi para orang tua sehingga orang tua juga memiliki bekal untuk membentuk karakter Kristus dalam diri anak mereka.
Немис тилини иккинчи чет тили сифaтидa мaсофaвий ўқитишдa янги aвлод ўқув aдaбиётлaрини яратиш методикаси ва уларнинг моделлари
Authors: Саттаров Уткир 
Published: April 2022

Ушбу мақола немис тилини иккинчи чет тили сифaтидa мaсофaвий ўқитишдa янги aвлод ўқув aдaбиётлaрини яратиш методикаси ва уларнинг моделлари хусусида бўлиб, унда ўқув адабиётларини яратиш методикаси, ўқув адабиётнинг таълим жараёнидаги функциялари, немис тилини иккинчи тил сифатида ўқитиш бўйича янги авлод ўқув адабиётлари амалий машғулотларда қўлланувчи дарсликлар ҳақида ҳам тўхталиб ўтилган.
A new dataset of river flood hazard maps for Europe and the Mediterranean Basin
Authors: Dottori Francesco , Alfieri Lorenzo , Bianchi Alessandra , Skoien Jon , Salamon Peter 
Published: April 2022

Abstract. In recent years, the importance of continental-scale hazard maps for
riverine floods has grown. Nowadays, such maps are used for a variety of
research and commercial activities, such as evaluating present and future
risk scenarios and adaptation strategies, as well as supporting management plans for national and
local flood risk. In this paper we present a new set of
high-resolution (100 m) hazard maps for river flooding that covers most
European countries, as well as all of the river basins entering the
Mediterranean and Black Sea in the Caucasus, the Middle East and northern
Africa. The new river flood hazard maps represent inundation along
329 000 km of the river network, for six different flood return periods,
expanding on the datasets previously available for the region. The input
river flow data for the new maps are produced by means of the hydrological
model LISFLOOD using new calibration and meteorological data, while
inundation simulations are performed with the hydrodynamic model
LISFLOOD-FP. In addition, we present here a detailed validation exercise
using official hazard maps for Hungary, Italy, Norway, Spain and the UK,
which provides a more detailed evaluation of the new dataset compared with
previous works in the region. We find that the modelled maps can identify on
average two-thirds of reference flood extent, but they also overestimate
flood-prone areas with below 1-in-100-year flood probabilities, while for
return periods equal to or above 500 years, the maps can correctly identify
more than half of flooded areas. Further verification is required in the northern
African and eastern Mediterranean regions, in order to better understand the
performance of the flood maps in arid areas outside Europe. We attribute the
observed skill to a number of shortcomings of the modelling framework, such
as the absence of flood protections and rivers with an upstream area below 500 km2 and the limitations in representing river channels and the topography of
lowland areas. In addition, the different designs of reference maps (e.g.
extent of areas included) affect the correct identification of the areas for
the validation, thus penalizing the scores. However, modelled maps achieve
comparable results to existing large-scale flood models when using similar
parameters for the validation. We conclude that recently released
high-resolution elevation datasets, combined with reliable data of river
channel geometry, may greatly contribute to improving future versions of
continental-scale river flood hazard maps. The new high-resolution database
of river flood hazard maps is available for download at
https://doi.org/10.2905/1D128B6C-A4EE-4858-9E34-6210707F3C81 (Dottori et
al., 2020a).
Cosmogenic ages indicate no MIS 2 refugia in the Alexander Archipelago, Alaska
Authors: Walcott Caleb K. , Briner Jason P. , Baichtal James F. , Lesnek Alia J. , Licciardi Joseph M. 
Published: April 2022

Abstract. The late-Pleistocene history of the coastal Cordilleran Ice Sheet remains
relatively unstudied compared to chronologies of the Laurentide Ice Sheet.
Yet accurate reconstructions of Cordilleran Ice Sheet extent and the timing
of ice retreat along the Pacific Coast are essential for paleoclimate
modeling, assessing meltwater contribution to the North Pacific, and
determining the availability of ice-free land along the coastal Cordilleran
Ice Sheet margin for human migration from Beringia into the rest of the
Americas. To improve the chronology of Cordilleran Ice Sheet history in the
Alexander Archipelago, Alaska, we applied 10Be and 36Cl dating to
boulders and glacially sculpted bedrock in areas previously hypothesized to
have remained ice-free throughout the local Last Glacial Maximum (LLGM;
20–17 ka). Results indicate that these sites, and more generally the coastal northern Alexander Archipelago, became ice-free by 15.1 ± 0.9 ka (n = 12 boulders; 1 SD). We also provide further age constraints on deglaciation along the southern Alexander Archipelago and combine our new ages with data from two previous studies. We determine that ice retreated from the outer coast of the southern Alexander Archipelago at 16.3 ± 0.8 ka (n = 14 boulders; 1 SD). These results collectively indicate that
areas above modern sea level that were previously mapped as glacial refugia
were covered by ice during the LLGM until between ∼ 16.3 and
15.1 ka. As no evidence was found for ice-free land during the LLGM, our
results suggest that previous ice-sheet reconstructions underestimate the
regional maximum Cordilleran Ice Sheet extent, and that all ice likely
terminated on the continental shelf. Future work should investigate whether
presently submerged areas of the continental shelf were ice-free.