bluuebunny/crossref_metadata_2025_split huggingface dataset:
Chemical degradation of BTK/TEC as a novel approach to inhibit platelet function and thrombosis
Authors: Trory Justin S. , Munkacsi Attila , Śledź Kamila M. , Goudswaard Lucy J. , Heesom Kate J. , Moore Samantha F. , Nabet Behnam , Aggarwal Varinder K. , Hers Ingeborg 
Published: May 2022

AbstractThe tyrosine kinase BTK plays an important role in platelet function downstream of GPVI and CLEC2 receptors and has been proposed as a novel target to prevent thrombosis in patients that are at increased risk. However, current clinically approved BTK inhibitors have off target effects and are associated with an increased bleeding risk. In this study, we therefore explored whether BTK can be targeted for degradation in human platelets by using recently developed heterobifunctional molecules that employ the proteasomal system to break down BTK. Here we confirm that human platelets are highly susceptible to BTK degraders with the generic tyrosine kinase degrader TL12-186, and the BTK degraders DD-04-15 and DD-03-171 leading to breakdown of BTK and its closely related kinase TEC, an effect that was prevented by proteasomal inhibitors. Tandem Mass Tag proteomic analysis confirmed high selectivity with TL12-186 degrading BTK/TEC, FAK/PYK2 and FER, whereas DD-04-15 and DD-03-171 degraded BTK/TEC only. GPVI-mediated platelet integrin αIIbβ3 activation, P-selectin expression, and phosphatidyl-serine exposure were largely impaired upon BTK/TEC degradation, with PAR-1-mediated responses left intact. This is the first study to demonstrate that chemical protein degraders can be successfully employed in anucleate human platelets to modulate their function.
A quick primer on Motivating Language Ability: a critical component of Motivating Language Theory
Authors: Holmes William T. 
Published: May 2022

Purpose
The purpose of this conceptual paper is to engage the field of leaders, practitioners, organizational trainers, and scholars into the idea that leader talk and the implementation of Motivating Language Theory takes ability. It takes thought and intentionality. It goes beyond just the use of the three leadership languages known as the Motivating Language Constructs that are so often written about in Motivating Language Theory research as “Motivating Language” when indeed they are not.

Design/methodology/approach
The conceptual approach behind this quick primer is to take previous research in Motivating Language Theory and refine and expand the work centered around Motivating Language Ability in order to bring greater attention and focus to Motivating Language and the necessary skills leaders need to bring it about.

Findings
The findings of this conceptual paper explicitly highlight levels of leader talk and Motivating Language usage and provides ideas and strategies for the implementation of Motivating Language Ability.

Research limitations/implications
The research implication of this conceptual paper is to assist scholars in clarifying their use of Motivating Language in research as there are times when researchers will identify Motivating Language in their research but not have Motivating Language as a significant variable.

Practical implications
The practical implication of this conceptual paper is to provide guidance and information to practitioners in the field on content that is critical for leader and organizational development.

Originality/value
The value of this conceptual paper is that it builds off of research already published and adds additional clarification and emphasis to an understudied and discussed element of Motivating Language Theory and leader talk in general.
Innovations and service firms’ performance: a firm-level mediating and moderating effects analysis for India
Authors: Islam Mohammad Monirul 
Published: May 2022

Purpose
This study aims to identify the effects of innovation types on the service firm’s financial and nonfinancial performance as well as mediation and moderation effects of innovation and the firms’ performance linkages in the Indian service sector.

Design/methodology/approach
This study uses combined data from the World Bank innovation survey 2014 and World Bank enterprise survey (WBES) 2014 for India. It classified innovations into technological innovation (service and process) and nontechnological innovation (organizational and marketing) and used financial and nonfinancial performance measures. This study applies variance-based partial least square structural equation modeling (PLS-SEM) using Smart PLS 3 software.

Findings
The study results suggest that service innovation has the highest significant effect on a firm’s financial and nonfinancial performance, followed by process innovation. Marketing and organizational innovation have a long route to contribute to a firm’s financial performance via innovative and nonfinancial performance. The study results do not find any synergy effects of innovation types. Multi-group analysis (MGA) results suggest several significant distinctions in the path relationships between small and medium-sizes and large firms.

Originality/value
This study provides several crucial policy suggestions for the managers and policymakers concerning the effects of service and process innovation on service firms’ performance in India and the mediating factors of these relationships. The study suggests that managers should pay the highest importance to service innovation to swiftly and markedly surge service firms’ financial and nonfinancial performances. In contrast, a service firm’s innovative performance mainly results from its organizational and marketing innovations.
Comparing regions globally: impacts of COVID-19 on supply chains – a Delphi study
Authors: Seuring Stefan , Brandenburg Marcus , Sauer Philipp C. , Schünemann Daphna-Sophie , Warasthe Ronakeh , Aman Sadaf , Qian Chen , Petljak Kristina , Neutzling Daiane Mülling , Land Anna , Khalid Raja Usman 
Published: May 2022

PurposeThe COVID-19 pandemic has challenged supply chains (SCs) around the globe unprecedentedly. This study aims to gain insights on the impacts of the pandemic on SCs and their management under consideration of different regional contexts on a global scale.Design/methodology/approachA Delphi study collects the expertise of global SC academics on the SC vulnerabilities and the measures for responding to disruptions, improving resilience, and restoring operations. Data from three polls are systematically analyzed by content, frequency, and cluster analysis.FindingsThe study identifies and ranks ten major issues related to SC vulnerabilities and management strategies for specific SC processes and geographical regions. Detected differences among the considered geographical regions point towards particular challenges and call for specific measures to integrate regional contingencies into SC management. In a regional comparison, China and Iran as well as Africa clearly stand out, but also Europe/North America, India/Pakistan, and Brazil show geographical particularities.Research limitations/implicationsThe responses are collected against the COVID-19 pandemic, while the findings show differences among the regions thereby arguing for taking regional contingencies into account in managing SCs.Practical implicationsSC resilience is a core aim, which was emphasized by the COVID-19 pandemic. The findings provide insights and challenges that managers would have to meet in the different regions covered.Originality/valueThis paper contributes to existing knowledge on SC risks and SC resilience in context to extreme situations. Given that events, such as the COVID-19 pandemic, will become more frequent in the future due to climate change and geopolitical tensions, insights into how to manage SCs under extreme conditions and into regional differences are crucial.
After-sales service shaping assortment satisfaction and online repatronage intention in the backdrop of social influence
Authors: Verma Pranay 
Published: May 2022

Purpose
This paper aims to analyze online repatronage intention (ORI) in the context of after-sales service (ASS) and assortment satisfaction (AS) for professional services. This study also aims to study the influence of ASS upon AS. Additionally, the role of social influence (SI) in influencing these two and other dependent variables is examined. Finally, the effect of moderation on these hypothesized relationships by four dichotomous variables is also investigated.

Design/methodology/approach
A structured questionnaire was used to collect data from 458 customers, who had a recent experience of ASS with their respective professional service providers, through purposive sampling method.

Findings
This empirical study establishes that ASS is an antecedent to AS and ORI. The finding of this empirical study also confirms that AS has a direct positive influence on ORI and customer loyalty. This implies that satisfied customers are more likely to repatronage the professional service and would be loyal to such professional service providers. The findings also reveal that all constructs are influenced by SI. Civil status, gender, city type (metro/non metro) and income status moderate a few of the hypothesized relationships, with city type having the maximum effect.

Originality/value
To the best of the author’s knowledge, this is the first study on online purchase of professional services which proves that ASS influences AS. Given the growth of online professional services, this study provides scholars and practitioners with suggestions and recommendations on how ASS and AS can be used to build ORI and a loyalty base. This study fills the void in extant literature by examining the interrelationships between ASS, assortment satisfaction, ORI and customer loyalty.
Sustainable businesses development in post-conflict zones: a case in rural Colombia
Authors: Lopez Barrera Emiliano , Peña-Lévano Luis , Lowenberg-DeBoer James , Fontanilla-Díaz Carlos , Mosquera-Montoya Mauricio 
Published: May 2022

PurposeFarmers in Colombia have faced economic instability due to a long-lasting armed conflict. An attempt to support the rural community has been through the creation of productive alliances – a strategic association between small-scale producers and anchor companies with the assistance of the private and public sectors. By closely examining the Association of Guarupay Palm Growers (ASOPAY)'s financial cash flows, this study investigates the challenges faced by small-scale agribusinesses in an emerging economy.Design/methodology/approachThis study addresses the situation of ASOPAY, an oil palm productive alliance formed by families displaced by the Colombian armed conflict and relocated in the eastern foothills of the Andes Mountains. By closely examining ASOPAY's financial flows, the article sheds light on the economic incentives enhancing the cohesion of the small-farmers’ association.FindingsA key finding is the critical role played by institutional efforts focused by promoting policies to enhance producers income. In addition, technological transfers made through technical assistance programs may improve the association's profitability by enhancing agronomic practices, while decreasing palm mortality and disease incidence.Research limitations/implicationsThe relatively small sample used in the study might rise concerns regarding the generalization of the outcomes. However, the authors implemented strategies to overcome these limitations by incorporating the inputs from experts on the oil palm supply chain in Colombia and from experts in rural development.Originality/valueTo the authors' knowledge, this is the first study analyzing the financial success of small farmers in post-conflict zones.
Archaeological site management and the legislation challenge in Vietnam: a case study of Vuon Chuoi
Authors: Nguyen Ky Nam , Phan Quang Anh , Nguyen Ngoc Minh 
Published: May 2022

Purpose This paper aims to examine the management status quo of archaeological heritage in Vietnam seen in the case of Vuon Chuoi, a complex of Bronze Age sites located in Central Hanoi, which has been believed to be Hanoi’s first human settlement. Like other archaeological sites located in urban areas, this site has been under threat of destruction caused by land encroachment pressure. Although researchers have long waged a campaign for preservation, the dissensus among key stakeholders and the dispute over responsibility have left this site at the heart of an interminable polemic over legislation.Design/methodology/approach This research utilises a qualitative approach, and the primary data were collected throughout multiple field trips in 2019 and 2020. Several open-ended interviews were conducted with various state and nonstate actors involved in the Vuon Chuoi Complex’s management process. The discussion was also supported by analysing related legal documents retrieved from national archives and official online directories.Findings This paper dissects the current legislative and administrative framework applied in governing heritage in general and archaeological sites in Vietnam, in particular. The results indicate that existing flaws in Vietnam’s legal system are detectable, and the unsystematic organisation has led to deferment of the decision-making processes. Also, there is an apparent difference found in the attitude of the bodies in charge toward the treatment of listed and unlisted sites.Originality/value This research outlines that in the wake of urbanisation and industrialisation in Vietnam, a consensus among key stakeholders and an inclusive legal system are required to help preserve archaeological sites in urgent need of attention. Although several Vietnamese laws and regulations have been put into practice, they have shown critical barriers and gaps in conserving Vietnamese cultural heritage.
Exploring the relationship between uniform and perceived employee happiness and productivity
Authors: Moody Louise 
Published: May 2022

PurposeThe purpose of this study is to contribute to understanding of employee's relationships with their uniforms and the perceived impact on their experiences at work. An improved understanding of this relationship may provide benefits for both the employee and the organisation. Recognising an ageing workforce and increasing female representation, differences based on gender and age are of interest.Design/methodology/approachThe study aimed to explore employee views and perceptions of uniform design and potential links to their happiness and productivity at work. An online survey was developed and completed by 2,560 uniform wearers. The data were analysed through descriptive and inferential statistics. Exploratory factor analysis uncovered latent variables from among the large number of survey items. A two-way factorial ANOVA compared perceptions based on gender and age.FindingsThe results suggest participants feel that their uniform has an impact on their happiness and behaviour at work. Differences in responses to their uniform were found based on gender and age. The survey tool enabled consideration of employee views and exploratory factor analysis identified five constructs of uniform design priorities: positive feelings, experience at work, suitability and practicality, tailored to the individual, visibility and brand.Originality/valueThis research is believed to be the first survey exploring the views of UK-based uniform wearers. Key elements of uniform design have been prioritised from the employee perspective to offer an emerging model to understand employee perceptions of uniform design. These findings inform uniform manufacturers and employers in designing and developing uniform to address the needs of employees.
Marketing and operational strategies during the COVID-19 pandemic: a case study of a Hong Kong footwear enterprise
Authors: Chan Hau-Ling , Kwok Yiu-Keung , Wong Shun-Mun 
Published: May 2022

PurposeThis study aims to examine the research trends in fashion industry during the coronavirus disease 2019 (COVID-19) pandemic. Besides, it also provides an overview on the new marketing and operational strategies, and reveals the corresponding business challenges of a footwear enterprise in Hong Kong during the COVID-19 pandemic.Design/methodology/approachA comprehensive literature review is first conducted to identify the research trends in fashion industry during the COVID-19 pandemic. A qualitative exploratory case study is then used to illustrate how a footwear enterprise has coped with the COVID-19 pandemic.FindingsThe case study has showed that omni-channel retailing, collaboration with e-tailers, quick response system and mixed production strategy are adopted in the targeted case during the COVID-19 pandemic. Besides, the targeted case has also faced the challenges in the areas of sales, customer relationship management, and demand forecasting and inventory planning during the COVID-19 pandemic.Originality/valueThis study provides managerial insights on the real practices used to deal with the COVID-19 pandemic and proposes various academic future research directions in fashion industry based on the real-world observations.
Multidimensional value of customers' mobile service experiences in the food service context
Authors: Kwon Jookyung , Yu Hoyeol , Ahn Jiseon 
Published: May 2022

PurposeDespite the importance of mobile experiences in the food service industry, extant studies do not empirically examine customers' behavior. Thus, the authors examine this issue by using utility theory to understand the role of multidimensional customers' perceived value in the formation of a positive attitude.Design/methodology/approachCustomers' perceived service, process, and relationship values are hypothesized to affect satisfaction, which in turn affects attitudinal loyalty to food delivery applications. Also, the authors explore whether attitudinal loyalty influences customers' behavioral loyalty. Hypotheses are examined using data from US customers of food delivery applications. Partial least squared structural equation modeling is used.FindingsResults show that customers' perceived service, process, and relationship valuation of mobile experiences influence satisfaction, whereas only the process value influences satisfaction and attitudinal loyalty. Moreover, customers' behavioral loyalty is positively affected by satisfaction and attitudinal loyalty.Research limitations/implicationsService, process, and relationship values have been shown as an important indicator of customers' positive attitude toward food delivery service providers. Thus, this study provides a better understanding of the relationship between customers' mobile service experience and their behavior will allow service providers to design better mobile services.Originality/valueThe study extends utility theory to mobile the food delivery context. Specifically, this research demonstrates why and how customers decide to use mobile food delivery application.
Trauma-informed training and education for professionals in Australia: a scoping review
Authors: McNaughton Kimie Maree , Isobel Sophie , Phelan Liam , Quilty Emma 
Published: May 2022

Purpose
Trauma-informed care and practice (TICP) has gained international attention since the mid-1990s, but its recent adoption in Australia has been met with various barriers, including a lack of training and education opportunities to enhance professional knowledge and practice. This paper aims to identify and further understand what is occurring in TICP training and education for health and human service professionals in Australia; specifically, what is known about TICP content and training strategies being used.

Design/methodology/approach
A scoping methodology was used to undertake a systematic search of the literature to identify and map the scope and nature of research activity on TICP training and education for professionals in Australia. Based on the predetermined inclusion and exclusion criteria, removal of duplications, abstract review and full-text screening, six studies met the inclusion criteria for content analysis in this review.

Findings
The studies showed that TICP training and education was occurring predominantly in the Australian health sector for nursing professionals and improved knowledge, confidence to respond to disclosures of trauma and approaches to care. Training was commonly delivered through one-day workshops and brief Web-based approaches. The findings suggested that there is a need for consensus on TICP content to ensure that fidelity to the principles of TICP is promoted in unique workplace settings and for ongoing commitment by relevant stakeholders and funding bodies.

Originality/value
To the best of the authors’ knowledge, this is the first review exploring what is happening across disciplines and sectors for trauma-informed education. The findings have implications for clinicians, professionals, educators and researchers.
Perceived competence overrides gender bias: gender roles, affective trust and leader effectiveness
Authors: Hu Lingyan , Jiang Ning , Huang He , Liu Yan 
Published: May 2022

PurposeDespite abundant research on the negative effect of gender stereotypes on female leaders, it remains unclear whether leader competence perceived by the subordinates could overcome this backlash effect. Drawing on expectation states theory and expectancy violation theory, the authors investigate how the interaction among leaders' gender roles, leader sex and subordinates' perceived leader competence influences leader effectiveness through subordinates' affective trust.Design/methodology/approachData were collected through two-wave surveys among 489 participants from various sectors in different parts of China. SPSS and Hayes PROCESS were used to test the hypotheses.FindingsHigh competence perceived by the subordinates helps female leaders to overturn the negative effect of masculinity and strengthen the positive effect of femininity, whereas this positive moderation does not hold for male leaders.Originality/valueThis study addresses the ongoing debate about “female advantage” in leadership by showing that female leaders benefit from high perceived competence and are penalized by low perceived competence to a greater extent than male leaders in terms of leader effectiveness.
A relational identification perspective on why and when servant leadership foster employees' extra-role customer service
Authors: Cai Di , Wang Haiyue , Yao Li , Li Mingyu , Men Chenghao 
Published: May 2022

PurposeCustomer service is crucial for organizations' survival and competitiveness in the hospitality industry. The purpose of this study is to examine how and when servant leadership affects extra-role customer service.Design/methodology/approachThe hypotheses were tested with a sample of 302 employees from a passenger transport company in China.FindingsResults demonstrate that servant leadership was positively related to extra-role customer service and that this relation was mediated by relational identification. In addition, the mediating effect of relational identification in the relation between servant leadership and extra-role customer service was contingent on prosocial motivation.Originality/valueThe study is the first to explore the relation between servant leadership and extra-role customer service from the perspective of relational identification and the moderating role of prosocial motivation.