bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identification of bacterial lipopeptides as key players in IBS
Authors: Petitfils Camille , Maurel Sarah , Payros Gaelle , Hueber Amandine , Agaiz Bahija , Gazzo Géraldine , Marrocco Rémi , Auvray Frédéric , Langevin Geoffrey , Motta Jean-Paul , Floch Pauline , Tremblay-Franco Marie , Galano Jean-Marie , Guy Alexandre , Durand Thierry , Lachambre Simon , Durbec Anaëlle , Hussein Hind , Decraecker Lisse , Bertrand-Michel Justine , Saoudi Abdelhadi , Oswald Eric , Poisbeau Pierrick , Dietrich Gilles , Melchior Chloe , Boeckxstaens Guy , Serino Matteo , Le Faouder Pauline , Cenac Nicolas 
Published: October 2022

ObjectivesClinical studies revealed that early-life adverse events contribute to the development of IBS in adulthood. The aim of our study was to investigate the relationship between prenatal stress (PS), gut microbiota and visceral hypersensitivity with a focus on bacterial lipopeptides containing γ-aminobutyric acid (GABA).DesignWe developed a model of PS in mice and evaluated, in adult offspring, visceral hypersensitivity to colorectal distension (CRD), colon inflammation, barrier function and gut microbiota taxonomy. We quantified the production of lipopeptides containing GABA by mass spectrometry in a specific strain of bacteria decreased in PS, in PS mouse colons, and in faeces of patients with IBS and healthy volunteers (HVs). Finally, we assessed their effect on PS-induced visceral hypersensitivity.ResultsPrenatally stressed mice of both sexes presented visceral hypersensitivity, no overt colon inflammation or barrier dysfunction but a gut microbiota dysbiosis. The dysbiosis was distinguished by a decreased abundance ofLigilactobacillus murinus, in both sexes, inversely correlated with visceral hypersensitivity to CRD in mice. An isolate from this bacterial species produced several lipopeptides containing GABA including C14AsnGABA. Interestingly, intracolonic treatment with C14AsnGABA decreased the visceral sensitivity of PS mice to CRD. The concentration of C16LeuGABA, a lipopeptide which inhibited sensory neurons activation, was decreased in faeces of patients with IBS compared with HVs.ConclusionPS impacts the gut microbiota composition and metabolic function in adulthood. The reduced capacity of the gut microbiota to produce GABA lipopeptides could be one of the mechanisms linking PS and visceral hypersensitivity in adulthood.
Twisted strings in three-dimensional black holes
Authors: Ashok Sujay K. , Troost Jan 
Published: October 2022

AbstractWe revisit the classical dynamics of fundamental strings in BTZ black holes with NSNS flux. We analyze probe strings in the black hole background and determine their classical energy using a Nambu–Goto action. Three-dimensional gravity has a non-local effect on the metric surrounding a massive object which can be measured by winding strings. We also study the behaviour of short and long strings in the Wess–Zumino–Witten orbifold and show that their energy matches the long string probe analysis. In the process, we fix subtleties in the Lorentzian choice of NSNS flux. In Euclidean signature, we analyze the one-loop fundamental string partition function on the BTZ black hole and interpret the off-shell degrees of freedom as those of a coset orbifold. Finally, we speculate on how to identify the quantum Lorentzian string spectrum from the Euclidean orbifold partition function.
The external photoevaporation of planet-forming discs
Authors: Winter Andrew J. , Haworth Thomas J. 
Published: October 2022

AbstractPlanet-forming disc evolution is not independent of the star formation and feedback process in giant molecular clouds. In particular, OB stars emit UV radiation that heats and disperses discs in a process called ‘external photoevaporation’. This process is understood to be the dominant environmental influence acting on planet-forming discs in typical star-forming regions. Our best studied discs are nearby, in sparse stellar groups where external photoevaporation is less effective. However, the majority of discs are expected to reside in much stronger UV environments. Understanding external photoevaporation is therefore key to understanding how most discs evolve, and hence, how most planets form. Here, we review our theoretical and observational understanding of external photoevaporation. We also lay out key developments for the future to address existing unknowns and establish the full role of external photoevaporation in the disc evolution and planet formation process.
Stratigraphy and Sedimentary Record of the Ordovician System in Poland: a Review
Authors: Trela Wiesław 
Published: October 2022

Abstract
This report provides insight into the main stratigraphic and sedimentary aspects of the Ordovician System in major tectonic units of Poland: (1) East European Craton, (2) Pomeranian Block, (3) Łysogóry Block, (4) Małopolska Block, (5) Upper Silesian Block, and (6) the Sudetes. The first studies of the Ordovician rocks in Poland were conducted as early as the second half of the nineteenth century in outcrops of the Holy Cross Mountains (SE Poland). Moreover, the Ordovician rocks are exposed in the Sudetes, where they are incorporated into the tectonostratigraphic units accreted during the Variscan orogeny. Significant progress has been made since the 1950s in the recognition of the Ordovician stratigraphic and facies architecture due to numerous drilling cores, which have been mostly made in NE Poland (East European Craton). The temporal and spatial facies pattern in the Polish part of the East European Craton indicate that in the Early and Middle Ordovician this area was a part of large, epicontinental carbonate platform replaced in the Late Ordovician by fine-grained clastics of distal shelf. The Ordovician sedimentary record in the Łysogóry and Małopolska blocks (SE Poland) reveals numerous similarities to the facies architecture in the neighbouring East European Craton, especially its marginal localities. Thus, it is possible to distinguish the same eustatic events in these units corresponding to sea-level changes reported in Baltica, although locally a regional tectonic activity masked their effects. The evolution of the sedimentary basin in NW Poland (Pomeranian Block) was influenced by the collision of Baltica with Avalonia in the Late Ordovician, which resulted in the development of the Caledonian fold-and-thrust belt.
Ordovician of the Eastern Baltic palaeobasin and the Tornquist Sea margin of Baltica
Authors: Meidla Tõnu , Ainsaar Leho , Hints Olle , Radzevičius Sigitas 
Published: October 2022

Abstract
This paper summarizes recent knowledge on the palaeontology, biostratigraphy, correlation, sea-level and climate history and isotopic geochemistry of the Ordovician rocks in the western and central parts of the East European Craton, in the area extending from the southern margin of the Fennoscandian Shield to the western margin of the Ukrainian Shield. The regional chronostratigraphic standard is briefly summarized and its correlation to the global standard of the Ordovician is addressed. A two-part correlation chart of 10 areas with unique local Ordovician successions is aligned with the most recent international correlation standard of the Ordovician System and presented against the regular timescale. An updated summary of the evolution of the marine assemblages is provided, the principal gaps in the existing extremely rich palaeontological database are identified and the main bioevents are discussed.
Berberine Inhibits Herpes Simplex Virus 1 Replication in HEK293T Cells
Authors: Cui Yujuan , Zhang Liangjun , Hu Dandong , Yang Yingli 
Published: October 2022

Berberine exhibits polytrophic medicinal roles in various diseases and is safe and effective. However, its role and the underlying mechanism in the replication of herpes simplex virus 1 (HSV-1) remain unreported. This research aimed to determine the functional mechanisms of berberine on HSV-1 infection. We determined the CC50 (

405.11
±
15.67

μM) and IC50 (

45.6
±
6.84

μM) of berberine on HEK293T cells infected with HSV-1. Berberine inhibited the transcription and translation of HSV-1 activity-related genes (gD, ICP-4, ICP-5, and ICP-8) in HSV-1-infected HEK293T cells dose-dependently. Berberine also inhibited the phosphorylation of MAPK proteins (JNK and p38) and inflammatory responses induced by HSV-1 infection in HEK293T cells dose-dependently. In conclusion, berberine attenuates HSV-1 replication through its activity, infective ability, and inflammatory response. Our research indicated that berberine may be a candidate drug for HSV-1 infection.
Attenuated Sympathetic Blood Pressure Transduction in Patients With Treated Heart Failure With Reduced Ejection Fraction
Authors: Nardone Massimo , Notarius Catherine F. , Badrov Mark B. , Millar Philip J. , Floras John S. 
Published: October 2022

Background:
Heart failure with reduced ejection fraction (HFrEF) is associated with reduced cardiac β-adrenergic signal transduction in response to chronic elevations in neurally released and circulating norepinephrine. Whether elevations in muscle sympathetic nerve activity (MSNA) are accompanied by attenuated α-adrenoceptor–mediated vasoconstriction remains unclear. Therefore, the objective of the current work was to compare transduction of sympathetic firing into blood pressure (BP) in treated patients with HFrEF and healthy controls.

Methods:
Twenty-three treated patients with HFrEF (4 females, left ventricular ejection fraction: 28±2%) and 22 healthy controls (6 females) underwent a 7-minute resting measurement of continuous beat-to-beat BP (finger photoplethysmography), heart rate (electrocardiography), and MSNA (microneurography). Sympathetic-BP transduction was quantified using both signal averaging, whereby the BP response to each MSNA burst was serially tracked over 15 cardiac cycles and averaged to derive the peak change in BP, and cross-spectral analysis of low-frequency (0.04–0.15 Hz) MSNA and BP oscillations.

Results:

Compared with controls, patients with HFrEF had less sympathetic-BP transduction (0.7±0.3 versus 0.2±0.3 mm Hg;
P
<0.01), and lower low-frequency oscillations in MSNA (120±56 versus 64±32 arbitrary units
2
;
P
<0.01) and BP (3.1±1.6 versus 2.0±1.7 mm Hg
2
;
P
<0.01). In subgroup analysis, resting sympathetic-BP transduction was lower in patients with HFrEF with normal resting MSNA compared to healthy controls (0.7±0.3 versus 0.4±0.3 mm Hg;
P
=0.01) and further attenuated (0.1±0.1 mm Hg;
P
=0.03) in patients with HFrEF with elevated resting MSNA.

Conclusions:
Treated HFrEF is associated with lower sympathetic-BP transduction, even when MSNA is not elevated, and diminishes further with disease progression. These adaptations may serve to limit the adverse consequences of oscillatory surges in sympathetic vasoconstrictor discharge on stroke volume.
Junzi 君子 as a Confucian Feminist Ideal
Authors: Herr Ranjoo Seodu 
Published: October 2022

Abstract
I propose a conception of Confucian feminism faithful to the original vision of the Confucian masters centered on the moral ideal of the junzi. Although the junzi 君子 has traditionally been conceived as male-gendered, my proposal for Confucian feminism is predicated on reclaiming the junzi as a gender-transcending feminist ideal. It follows in the footsteps of two premodern Korean female Confucian scholars, Yun-ji-dang and Chōng-il-dang, who deserve to be considered the first Confucian feminists. Recognizing their Confucian feminism’s limitations, however, I explore necessary conditions for reimagining the ideal of the junzi as a feminist ideal in contemporary Confucian East Asia.
Qing 情 in Confucian Thought
Authors: Shun Kwong-loi 
Published: October 2022

Abstract
While the term qing is often translated as “emotions”, it differs from the contemporary notion of emotions in two respects. Its scope also includes such items as likes, dislikes and desires, and it is often used to refer not just to the actual responses of humans but also to the condition of the heart/mind that underlies such responses. The paper examines the evolvement of the term leading to this usage, and explores the different views of qing that evolved leading to the Song-Ming Confucian view of qing as a basic part of the human constitution that needs to be properly nourished.
Tycho Brahe’s Health and Death: What Can We Learn from the Trace Element Levels Found in His Hair and Bone Samples?
Authors: Karpenko Vladimír , Kučera Jan 
Published: October 2022

Abstract
Based on the analysis of Tycho Brahe’s hair and bones for the presence of elevated levels of the elements iron (Fe), cobalt (Co), arsenic (As), silver (Ag) and gold (Au), this paper tries to find their likely sources and to judge whether the unusual concentrations in which they were found could have been due to some form of medication. On the basis of an osteopathological study, an attempt is made moreover to arrive at a comprehensive picture of Brahe’s health. As a possible source of the elements in question, his three elixirs and their compositions are discussed. Additionally, further inorganic medicines of the period containing the above-mentioned elements are presented and, where possible, their medical usage is discussed. While a combination of pathological data and probable medication is used to draw a general picture of Brahe’s health and potential illnesses, some questions cannot be conclusively answered, however, until more data about the astronomer’s health conditions come to light.
Assessing the Projected Changes in European Air Stagnation due to Climate Change
Authors: Maddison Jacob W. , Abalos Marta , Barriopedro David , García-Herrera Ricardo , Garrido-Perez Jose M. , Ordóñez Carlos , Simpson Isla R. 
Published: October 2022

Abstract
Air pollution is a major environmental threat to human health. Pollutants can reach extreme levels in the lower atmosphere when weather conditions permit. As pollutant concentrations depend on scales and processes that are not fully represented in current global circulation models (GCMs), and it is often too computationally expensive to run models with atmospheric chemistry and aerosol processes, air stagnation is often used as a proxy for pollution events with particular success in Europe. However, the variables required to identify air stagnation can have biases in GCM output, which adds uncertainty to projected trends in air stagnation. Here, the representation of air stagnation in GCMs is assessed for Europe in the historical period and in end-of-century projections based on a high-emission scenario using three methods for identifying air stagnation. The monthly frequency of stagnation during summer and autumn is projected to increase with climate change when stagnation is identified by a well-established index. However, this increase is not present when air-stagnation frequency is estimated using a statistical model based on the synoptic- to large-scale atmospheric circulation. This implies that the projected increases in air stagnation are not driven by an increase in frequency or severity of large-scale circulation events that are conducive to stagnation. Indeed, projected changes to the atmospheric circulation in GCMs, in particular a reduction in atmospheric block frequency, would suggest a reduction in future air stagnation. Additional analyses indicate that the projected increases in stagnation frequency follow the trend toward more frequent dry days, which is apparently unrelated to the large-scale drivers of air stagnation.
Dynamics and Impacts of the North Pacific Eddy-Driven Jet Response to Sudden Stratospheric Warmings
Authors: Dai Ying , Hitchcock Peter , Simpson Isla R. 
Published: October 2022

Abstract
In this study, observations and simulations are used to investigate the mechanisms behind the different surface responses over the North Pacific and North Atlantic basins in response to sudden stratospheric warmings associated with a polar-night jet oscillation event (PJO SSWs). In reanalysis and a free-running preindustrial simulation, on average, a negative North Atlantic Oscillation (NAO) response is seen, corresponding to an equatorward shift of the eddy-driven jet. This is considered as the canonical tropospheric response to PJO SSWs. In contrast, the response over the North Pacific is muted. This basin-asymmetric response is shaped by the North Pacific air–sea interactions spun up by the tropospheric precursor to PJO SSWs, which prevent the Pacific eddy-driven jet from responding to the downward influence from the stratosphere. To isolate the downward influence from the sudden warming itself from any preconditioning of the troposphere that may have occurred prior to the warming, a nudging technique is used by which a reference PJO SSW is artificially imposed in a 195-member ensemble spun off from a control simulation. The nudged ensembles show a more basin-symmetric negative Northern Annular Mode (NAM) response, in which the eddy-driven jet shifts equatorward in both the Pacific and Atlantic sectors. Monitoring the atmospheric and oceanic conditions in the North Pacific before and at the onset of PJO SSWs may be useful for forecasting whether a basin-asymmetric negative NAO or basin-symmetric negative NAM response is more likely to emerge. This can be further used to improve subseasonal-to-seasonal predictions of weather and climate.

Significance Statement
Stratospheric sudden warming events (SSWs) occur when the eastward winds usually found above the Arctic in the winter spontaneously and rapidly reverse. Following their occurrence, the Northern Hemisphere surface westerlies move southward, sometimes over both the North Atlantic and North Pacific and other times over the North Atlantic only. We therefore wanted to understand this uncertainty in the North Pacific surface westerlies response. We find that the North Pacific surface westerlies response to SSWs can be muted by air–sea interactions over the North Pacific. Our results highlight the importance of monitoring the atmospheric and oceanic conditions in the North Pacific before the occurrence of SSWs to forecast whether the Pacific westerlies are likely to respond to SSWs.
Characteristics of Surface “Melt Potential” over Antarctic Ice Shelves based on Regional Atmospheric Model Simulations of Summer Air Temperature Extremes from 1979/80 to 2018/19
Authors: Orr Andrew , Deb Pranab , Clem Kyle R. , Gilbert Ella , Bromwich David H. , Boberg Fredrik , Colwell Steve , Hansen Nicolaj , Lazzara Matthew A. , Mooney Priscilla A. , Mottram Ruth , Niwano Masashi , Phillips Tony , Pishniak Denys , Reijmer Carleen H. , van de Berg Willem Jan , Webster Stuart , Zou Xun 
Published: October 2022

Abstract
We calculate a regional surface “melt potential” index (MPI) over Antarctic ice shelves that describes the frequency (MPI-freq; %) and intensity (MPI-int; K) of daily maximum summer temperatures exceeding a melt threshold of 273.15 K. This is used to determine which ice shelves are vulnerable to melt-induced hydrofracture and is calculated using near-surface temperature output for each summer from 1979/80 to 2018/19 from two high-resolution regional atmospheric model hindcasts (using the MetUM and HIRHAM5). MPI is highest for Antarctic Peninsula ice shelves (MPI-freq 23%–35%, MPI-int 1.2–2.1 K), lowest (2%–3%, <0 K) for the Ronne–Filchner and Ross ice shelves, and around 10%–24% and 0.6–1.7 K for the other West and East Antarctic ice shelves. Hotspots of MPI are apparent over many ice shelves, and they also show a decreasing trend in MPI-freq. The regional circulation patterns associated with high MPI values over West and East Antarctic ice shelves are remarkably consistent for their respective region but tied to different large-scale climate forcings. The West Antarctic circulation resembles the central Pacific El Niño pattern with a stationary Rossby wave and a strong anticyclone over the high-latitude South Pacific. By contrast, the East Antarctic circulation comprises a zonally symmetric negative Southern Annular Mode pattern with a strong regional anticyclone on the plateau and enhanced coastal easterlies/weakened Southern Ocean westerlies. Values of MPI are 3–4 times larger for a lower temperature/melt threshold of 271.15 K used in a sensitivity test, as melting can occur at temperatures lower than 273.15 K depending on snowpack properties.
Baroclinic Tidal Cusps from Satellite Altimetry
Authors: Zaron Edward D. 
Published: October 2022

Abstract
The spatially averaged frequency spectrum of sea level has been computed at 4 cycle-per-year resolution and a Nyquist frequency of 0.5 cycles per hour using dual-satellite crossover data from the Jason and CryoSat-2 satellite altimeter missions. The novelty of the analysis is that it reveals unambiguous peaks due to high-frequency tidal signals, even after removing the predicted barotropic tide, without the usual aliasing caused by altimeter sampling. The tidal continuum, that is, a tidal cusp, is present in the spectrum in the diurnal and semidiurnal tidal bands, and a Lorentzian model spectrum has been fit within each band to identify the properties of the non-phase-locked tidal variability. An interesting feature of the semidiurnal tidal continuum is the unambiguous presence of an inner and an outer band, characterized by different Lorentzian bandwidths of roughly (180 day)−1 and (30 day)−1. Considering different latitude ranges, it is clear that the tidal continuum is most prominent in the range from −30° to 30° latitude. Within this range, it is found that 1.05-cm2 variance is associated with the semidiurnal continuum, and slightly less than half of this variance, 0.41 cm2, is associated with the slower, (180 day)−1 bandwidth, variability. The ratio of non-phase-locked to total baroclinic variability is about 62% in this latitude band, a value that is consistent with previous model-based estimates for this quantity. Quantification of the properties of the tidal continuum poleward of 30° latitude is not possible with the present data, due to the small size of the tidal signal compared to the mesoscale variability and other sources of noise.