bluuebunny/crossref_metadata_2025_split huggingface dataset:
NEUROPROTECTIVE EFFECT OF VANDA TESSELLATA AS “RASNA” SPECIES, ON ALUMINIUM CHLORIDE INDUCED ALZHEIMER’S IN RATS
Authors: Raju Asirvatham , Salwa Abdul Salam , Daisy Punnackal Augustine , Aparna Ann Mathew , Boby Johns 
Published: April 2022

The present study focused on evaluation of neuroprotective effect of hydromethanolic extracts of Vanda tessellate (VT), also considered as Rasna. Aluminum Chloride (AlCl3) induces neuroinflammation in rats and finally the development of AD. PASS online and molecular docking insilico studies were conducted with PPAR-γ for β-sitosterol and AChE for gigantiol. Total 36 trained Wistar rats were divided into VI groups 6 in each. Group I - normal control, Group II – Disease control, Group III – Rivastigmine (0.3mg/kg, p.o), Group IV and V – Hydromethanolic extract of VT (HMEVT, 150mg/kg, 300mg/kg, p.o) respectively, Group VI - Ayurvedic Formulation of Rasna (AFR) (1ml/kg, p.o). All the animals received Aluminum Chloride (AlCl3) (300mg/kg, p.o) except group I. The rats were treated for 20 days but mean time behavioural study, body weight changes were monitored on 0th, 7th, 14th& 20th day. On 21th day, rats were sacrificed, brains were isolated, then antioxidant enzymes levels, protein content and neurotransmitters levels were determined. Histopathology of cortex and hippocampus parts of the brain were studied. Group II animals showed reduction in locomotor activity, increased in the number of entries as well as time spent in closed arm and time taken to climb the pole was increased but it was reversed in groups treated with 150mg/kg, 300mg/kg doses of HMEVT and AFR. Increased level of protein content, malondialdehyde, reduction in body weight and antioxidants enzymes like superoxide dismutase, catalase, glutathione were observed in disease control group and it was due to free radicals generation and were corrected and restored in groups treated with HMEVT and AFR. Moreover, the histopathological report also showed cellular level protection efficacy found with HMEVT and AFR. The neuroprotective action of HMEVT was due to the active constituents and was proved in insilico study. The order of neuroprotective efficacy was HMEVT > AFR.
Economic analysis of hospital/healthcare costs in patients with colorectal digestive anastomosis
Authors:   Department of General Surgery, „Prof. Dr. D. Gerota” Emergency Hospital , Bucharest, Romania, Munteanu Rares , Burcos Traean ,   „Carol Davila” University of Medicine and Pharmacy, Department of General Surgery, Coltea Hospital, Bucharest, Romania, Grama Florin ,   „Carol Davila” University of Medicine and Pharmacy, Department of General Surgery, Coltea Hospital, Bucharest, Romania, Dumitrescu Dan ,   „Carol Davila” University of Medicine and Pharmacy, 4th Surgery Department, Emergency University Hospital, Bucharest, Romania
Published: April 2022

Abstract: Intestinal anastomoses have always been a major problem in digestive surgery. With the use of mechanical suture devices, intestinal anastomosis techniques have improved, allowing standardization of methods and shorter duration of surgical procedures. In addition to shortening the operative time, reduced operating room utilization and length of stay (LOS), health financial strain is also reduced by a lower rate of postoperative complications, quicker recovery and socioprofessional reintegration of patients, and by lowering costs related to treating permanent disabilities such as permanent intestinal stoma. The aim of this study was to estimate the costs of surgical patients with colorectal anastomosis (mechanical or manual suturing) and to identify economically efficient surgical techniques. Material and method: Unicentric 10-year retrospective study in the Bucharest "Prof. Dr. D. Gerota" Emergency Hospital. The costs associated with manually constructed and stapled anastomoses in colorectal surgery were compared. Results: In the group with manual colorectal anastomoses (363 patients) the costs per patient were on average 5190 RON and the average hospital stay 14.95 days. In the group with mechanical colorectal anastomoses (97 patients) the average cost per patient was 5037 RON with an average hospital stay of 11.5 days. Conclusions: The use of mechanical colorectal suture devices resulted in a cost reduction of approximately 150 RON per case and a shortening of average hospital stay by 3.45 days. In addition to these direct benefits, we also list the increase in surgical volume (including the diversification of the range of operations) or indirect effects such as faster socioprofessional reintegration of patients. Keywords: intestinal anastomosis, mechanical sutures, costs
Overview of clinical trials of drugs for the treatment of patients with new coronavirus infection (COVID-19)
Authors: Shirobokov Yaroslav E. , Gladunova Elena P. , Borodulina Elena A. 
Published: April 2022

BACKGROUND: The new coronavirus infection (SARS-CoV-2), better known as COVID-19, quickly evolved into a worldwide pandemic with a significant public health burden. Currently, there are no approved drugs or preventive therapeutic strategies to combat infection. However, there are hundreds of clinical studies around the world to discover effective treatments for COVID-19.
AIM: The purpose of the research is to conduct a content analysis of the published clinical trials devoted to the treatment of COVID-19, as well as to the synthesis of clinical experience in order to gain insight into potentially effective drugs.
MATERIALS AND METHODS: Clinical results published in PubMed, Medline, eLIBRARY, Cochrane Library.
RESULTS: The review summarized the results of clinical studies of potential therapeutic drugs used in COVID-19 therapy.
CONCLUSIONS: By the 15 of August 2021 no medications had been registered to treat the infection.
Gene expression of the congenital immunity in tissues of the placenta and fetal membranes in full-term pregnancy
Authors: Kaganova Maria A. 
Published: April 2022

AIM: To assess the level of expression of TLR2, TLR4, TLR7 genes in the placenta and fetal membranes during full-term physiological pregnancy, without signs of onset of labor.
MATERIALS AND METHODS: The study was carried out at the premises of City Clinical Hospital No. 1 named after N.I. Pirogov (Samara), and included 15 pregnant women at 37-41 weeks of gestation without somatic pathology, exacerbation of chronic and acute inflammatory diseases, obstetric complications (placental insufficiency, preeclampsia). All patients were delivered by elective caesarean section due to fetal malposition. The level of expression of TLR2, TLR4, TLR7 genes was determined by reverse transcription and real-time PCR (RT-PCR) on the basis of the laboratory of NPO DNA-Technology using a set of reagents Proba NK.
RESULTS: The data on the features of TLR2, TLR4, TLR7 expression in the placenta and membranes during full-term pregnancy were obtained. Direct correlations were found between the production of TLR2, TLR4, TLR7 of the fetal membranes and TLR2 of the placenta. The expression of placental TLR4 and TLR7 was not associated with the production of the TLRs. Significant differences were revealed in pregnant women with inflammatory and involutive-dystrophic changes in the placenta and the level of TLR4 expression.
CONCLUSIONS: The expression of the Toll-like receptors (TLRs) in the tissues of the fetoplacental complex occurs uniformly during physiological pregnancy. There are positive correlations between the expression of TLR2, TLR4, TLR7 of the fetal membranes and TLR2 of the placenta, as well as its mass. The most significant indicator of the inflammatory process is the placental expression of TLR4.
Teologi Misi sebagai Teologi Amanat Agung
Authors: Widjaja Fransiskus Irwan , Ginting Daniel , Hutagalung Sabar Manahan 
Published: April 2022

From the beginning of human creation, God's call never changes. Since the first man fell into sin, God has continued to take the initiative to look for the lost, from the old covenant to the new covenant and even himself sent, but to this day, the world is still not evangelized. Jesus himself was present for three and a half years, and sent twelve disciples, even the calling and commission of the Great Commission was continued by the church and believers, but from the facts and facts, the world was still not entirely accessible. After two thousand years, the call and commission of the Great still cannot be fulfilled. This article is a reflective study using a hermeneutical approach to biblical texts that speak of the great commission of Jesus Christ. Mission theology is the theology of the Great Commission needs to be developed to complete. AbstrakDari awal penciptaan manusia, panggilan Allah tidak pernah berubah. Sejak manusia pertama jatuh dalam dosa, Allah terus berinisiatif mencari yang terhilang, dari perjanjian lama sampai perjanjian baru bahkan diriNya sendiri di utus, tetapi sampai hari ini, dunia masih tetap belum terinjili. Yesus sendiri hadir selama tiga setengah tahun, dan mengutus dua belas murid, bahkan panggilan dan tugas Amanat Agung dilanjutkan oleh gereja dan orang percaya, tetapi dari fakta dan kenyataan, dunia masih belum seluruhnya terjangkau. Setelah dua ribu tahun, panggilan dan amanat Agung tetap belum bisa digenapi. Artikel ini merupakan kajian reflektif dengan menggunakan pendekatan hermeneutis atas teks-teks Alkitab yang berbicara tentang amanat agung Yesus Kristus. Teologi misi merupakan teologi Amanat Agung perlu dikembangkan untuk menuntaskan.
Membangun Pola Pengajaran melalui Mezbah Keluarga sebagai Gaya Hidup Keluarga Kristen Masa Kini
Authors: Baskoro Paulus Kunto , Budiyana Hardi 
Published: April 2022

Family is the best place for education. Good education for fathers, mothers and especially for children. Because children are an inheritance for the next family. What happens in family life become a patron for orther families. A strong family will build a strong church, a strong church will bulid a strong country. Many people underestimate an education in the family. So that it cannot be denied that there are so many Chirstian families that have experienced destruction because they do not have a correct teaching pattern. Education in the family must be built with the best teaching patterns. The family altar is one of the best patterns of family education. This is important to understand and imply in today’s family life into a lifestyle to build teaching patterns. This writing uses a descriptive literature method to provide and ideal description of the teaching pattern in the family through the family altar for each heart. With an end goal. First, every family realizes how important the family altar is to be part of Christian family ecudation; Second, the entire Christian family applies this pattern of teaching to the family which becomes a divine inheritance for all of its descendants; Third, the formation of a strong Christian family and a strong spiritual life, because is hat the best teaching pattern through the family prayer altar. AbstrakKeluarga menjadi tempat yang terbaik bagi sebuah pendidikan. Baik pendidikan bagi bapak, ibu dan terlebih bagi anak-anak. Sebab anak-anak adalah warisan bagi keluarga selan-jutnya. Apa yang terjadi dalam kehidupan keluarga menjadi sebuah patron bagi keluarga yang lain. Keluarga yang kuat akan membangun sebuah gereja yang kuat, gereja yang kuat akan membangun sebuah negara yang kuat. Banyak orang menganggap sepele sebuah pendidikan dalam keluarga. Sehingga tidak bisa dipungkiri banyak sekali keluarga-keluarga Kristen yang mengalami kehancuran karena tidak memiliki sebuah pola pengajaran yang benar. Pendidikan dalam keluarga harus dibangun dengan sebuah pola pengajaran yang terbaik. Mezbah keluarga menjadi salah satu pola yang terbaik dalam pendidikan keluarga. Hal ini penting untuk dipahami dan diimplikasikan dalam kehidupan keluarga masa kini menjadi sebuah gaya hidup membangun pola pengajaran. Penulisan ini menggunakan metode diskriptif literatur untuk memberikan pemapa-ran yang ideal tentang pola pengajaran dalam keluarga melewati mezbah keluarga setiap hati. Dengan sebuah tujuan akhirnya Pertama, setiap keluarga menyadari betapa pentingnya mezbah keluarga menjadi bagian pendidikan keluarga Kristen; Kedua, seluruh keluarga Kristen menerap-kan pola pengajaran tersebut dalam keluarga yang menjadi sebuah warisan ilahi bagi seluruh keturunannya; Ketiga, terbentukanya keluarga Kristen yang kuat dan kehidupan rohani yang kokoh, karena memiliki pola pengajaran terbaik lewat mezbah doa keluarga.
Quality of Health Services on Outpatient Satisfaction Levels: A Literature Review
Authors: Harahap Afni Basyariah , G Ermi , Nasution Sri Lestari Ramadhani 
Published: April 2022

The aims of the study is to determine the Service Quality on Outpatient Satisfaction Level. Patient satisfaction is a critical metric that is frequently used to assess the quality of health care services. Clinical outcomes, patient retention, and medical malpractice lawsuits are all affected by patient satisfaction. Patients are satisfied when they receive services that fulfill their expectations; they then opt to rate the services and behave based on their satisfaction. Service quality comprises five dimensions: reliability, responsiveness, assurance, empathy, and concrete value. Institutions must take numerous steps to ensure reliable services, including continual education and training of staff
Innovative Application of Soy Protein Isolate and Combined Crosslinking Technologies to Enhance the Structure of Gluten-Free Rice Noodles
Authors: Ojukwu Moses , Mat Easa Azhar 
Published: April 2022

Soy protein isolate (SPI) may serve as a health-enhancing functional ingredient in many food products due to the content of isoflavones. However, the high protein content may also be exploited as a structure modifier in gluten-free noodles. We applied Soy protein isolate to improve rice flour noodles’ structure, textural, and cooking properties by combining cross-linking and cold gelation of soy protein isolate using microbial transglutaminase and glucono-δ-lactone, respectively. The simultaneous cross-linking yielded noodles with improved structure and textural properties, mainly due to a more robust microstructure resulting from an increase in intermolecular protein cross-linking promoted by microbial transglutaminase and glucono-δ-lactone. However, the structurally enhanced noodles showed longer cooking time and reduced cooking yield upon drying. This was solved by employing pre-drying steaming treatments for 5 or 10 min to yield noodles with shorter cooking times, lower cooking losses, and improved cooking yield. We have also developed an alternative process technology using superheated steam (SHS) technology. The superheated steam technology made it possible to open up the structurally enhanced air-dried noodles by promoting faster gelatinization, as evidenced by reduced enthalpy, increased cooking yield, and sustained crystallinity of the starch granules noodle matrix.
Factors related to overweight and obese populations maintaining metabolic health
Authors: Lin Yi-Hsuan , Chang Hsiao-Ting , Tseng Yen-Han , Chen Harn-Shen , Chiang Shu-Chiung , Chen Tzeng-Ji , Hwang Shinn-Jang 
Published: April 2022

Background
For people who are overweight or obese, maintaining a metabolically healthy status can decrease the risks of developing cardiovascular diseases and Type 2 diabetes. Despite this, only a limited amount of research has discussed the metabolically healthy overweight and obesity (MHOO) population in Asia and the factors associated with them maintaining their metabolic health.

Methods
This study enrolled 195 MHOO participants from communities in northern Taiwan during 2009–2010 (baseline). Of the 195 participants, 89 completed the follow-up assessment after a median follow-up time of nine years. Body type was determined by body mass index (BMI, kg/m2). We defined overweight as a BMI ≥ 24 kg/m2 and <27 kg/m2 and defined obese as a BMI ≥ 27 kg/m2. Metabolic health was defined as the absence of cardiometabolic diseases and the presence of ≤1 of the cardiometabolic risk factors, namely hypertension, hyperglycemia, hypertriglyceridemia, and low serum high-density lipoprotein cholesterol. Metabolic health, BMI, and other covariates were evaluated at both baseline and follow-up. Generalized estimating equations (GEE) models were used to analyze the factors associated with maintenance of metabolic health during the follow-up period.

Results
At baseline, the mean age of the study participants was 47.4 (SD 5.3) years and 46 (51.7%) of the participants were women. There were 51 (57.3%) individuals who maintained their metabolic health status at the time of the nine-year follow-up. The detrimental factors pertaining to metabolic health included older age, longer duration until follow-up, BMI ≥ 27 kg/m2, and increase in waist circumference. No significant relationships were observed between sociodemographic factors and lifestyle factors, such as sex, level of education, cigarette smoking, alcohol consumption, and physical activity, and sustained metabolic health among MHOO individuals.

Conclusions
To maintain metabolic health and prevent negative changes in health status, control of bodyweight and waist circumference should remain a priority for MHOO individuals even when there are no metabolic disorders present.
A roadmap for sustaining biodiversity and ecosystem services through joint conservation and restoration of northern drainage basins
Authors: Heino Jani , Koljonen Saija 
Published: April 2022

Abstract1. Freshwater ecosystems and their biota are more seriously threatened than their marine and terrestrial counterparts. A solution to halt increasing negative impacts of anthropogenic development would be to reconsider the basics of nature conservation (i.e. protection of pristine and near‐pristine areas) and restoration (i.e. returning an impacted site to as natural condition as possible) through inclusion of the knowledge on abiotic and biotic dynamics of rivers draining pristine catchments. In boreal and Arctic regions, such comparisons are still possible because in addition to harbouring strongly modified drainage basins, some of the most natural drainage basins are also situated in these high‐latitude areas.2. A suitable approach for simultaneous planning of joint river conservation and restoration would be to (i) examine how well different kinds of rivers are covered by existing protected area networks and (ii) to restore parts of degraded rivers to facilitate colonization by aquatic and riparian organisms that have found havens in existing protected areas. This joint approach is a two‐way road, as conservation and restoration benefit from each other by allowing river networks to facilitate movements of organisms and matter, thereby mimicking natural riverine meta‐systems in anthropogenically modified drainage basins, with restored sites acting as stepping‐stones between protected areas.3. We argue that existing policy instruments should consider the fact that river ecosystems are spatially and temporally dynamic meta‐systems. These characteristics should be given due attention in conservation and restoration rather than relying on a static approach where a snap‐shot classification of river reaches is thought to be enough without considering underlying ecological dynamics. Taking ecological dynamics into account would contribute to sustainable management and maintenance of biodiversity and ecosystem services.
Motion modeling from 4D MR images of liver simulating phantom
Authors: Kavaluus Henna , Koivula Lauri , Salli Eero , Seppälä Tiina , Saarilahti Kauko , Tenhunen Mikko 
Published: April 2022

AbstractBackground and purposeA novel method of retrospective liver modeling was developed based on four‐dimensional magnetic resonance (4D‐MR) images. The 4D‐MR images will be utilized in generation of the subject‐specific deformable liver model to be used in radiotherapy planning (RTP). The purpose of this study was to test and validate the developed 4D‐magnetic resonance imaging (MRI) method with extensive phantom tests. We also aimed to build a motion model with image registration methods from liver simulating phantom images.Materials and methodsA deformable phantom was constructed by combining deformable tissue‐equivalent material and a programmable 4D CIRS‐platform. The phantom was imaged in 1.5 T MRI scanner with T2‐weighted 4D SSFSE and T1‐weighted Ax dual‐echo Dixon SPGR sequences, and in computed tomography (CT). In addition, geometric distortion of the 4D sequence was measured with a GRADE phantom. The motion model was developed; the phases of the 4D‐MRI were used as surrogate data, and displacement vector fields (DVF's) were used as a motion measurement. The motion model and the developed 4D‐MRI method were evaluated and validated with extensive tests.ResultThe 4D‐MRI method enabled an accuracy of 2 mm using our deformable phantom compared to the 4D‐CT. Results showed a mean accuracy of <2 mm between coordinates and DVF's measured from the 4D images. Three‐dimensional geometric accuracy results with the GRADE phantom were: 0.9‐mm mean and 2.5 mm maximum distortion within a 100 mm distance, and 2.2 mm mean, 5.2 mm maximum distortion within a 150 mm distance from the isocenter.ConclusionsThe 4D‐MRI method was validated with phantom tests as a necessary step before patient studies. The subject‐specific motion model was generated and will be utilized in the generation of the deformable liver model of patients to be used in RTP.
Hidden Local Symmetry Breaking in Silver Diamondoid Compounds is Root Cause of Ultralow Thermal Conductivity
Authors: Xie Hongyao , Bozin Emil S. , Li Zhi , Abeykoon Milinda , Banerjee Soham , Male James P. , Snyder G. Jeffrey , Wolverton Christopher , Billinge Simon J. L. , Kanatzidis Mercouri G. 
Published: April 2022

AbstractTypically, conventional structure transitions occur from a low symmetry state to a higher symmetry state upon warming. In this work, an unexpected local symmetry breaking in the tetragonal diamondoid compound AgGaTe2 is reported, which, upon warming, evolves continuously from an undistorted ground state to a locally distorted state while retaining average crystallographic symmetry. This is a rare phenomenon previously referred to as emphanisis. This distorted state, caused by the weak sd3 orbital hybridization of tetrahedral Ag atoms, causes their displacement off the tetrahedron center and promotes a global distortion of the crystal structure resulting in strong acoustic–optical phonon scattering and an ultralow lattice thermal conductivity of 0.26 W m−1 K−1 at 850 K in AgGaTe2. The findings explain the underlying reason for the unexpectedly low thermal conductivities of silver‐based compounds compared to copper‐based analogs and provide a guideline to suppressing heat transport in diamondoid and other materials.
Bacteria‐Elicited Specific Thrombosis Utilizing Acid‐Induced Cytolysin A Expression to Enable Potent Tumor Therapy
Authors: Qin Wenjun , Xu Wenxuan , Wang Longyu , Ren Debao , Cheng Yibin , Song Wen , Jiang Tao , Ma Lixin , Zhang Cheng 
Published: April 2022

AbstractGiven the special microenvironment of solid tumors, live microorganisms have emerged as drug delivery vehicles and therapeutic agents. Here, an acid‐induced therapeutic platform is constructed using attenuated Escherichia coli to express the cytolysin A protein. The bacteria can target and colonize tumor tissues without causing notable host toxicity. Bacterial infection can disrupt blood vessels and trigger thrombosis in tumor tissues, resulting in the cut‐off of nutrient supply to tumor cells and the arrest of tumor growth. The expression of cytolysin A induced by the acidic tumor microenvironment further strengthens thrombosis and provides a complementary therapeutic option due to its pore‐forming function. In a xenograft mouse tumor model, this strategy reduces tumor proliferation by 79% and significantly prevents tumor metastasis, thus paving a new avenue for bacteria‐based tumor therapy.