bluuebunny/crossref_metadata_2025_split huggingface dataset:
Inventory dispensation and restocking in multiclass inventory systems: A decoupling approach
Authors: Wang Lu , Kulkarni Vidyadhar , Zhang Hanqin 
Published: September 2022

We consider an inventory system with Poisson demand arrivals arising from multiple classes. Restocking epochs are specified by a given sequence. At each epoch, we can place an order for any number of items for immediate delivery. We have to decide the inventory dispensation policy, which determines whether we should satisfy a demand, or reject it, or backlog it until the next restocking epoch. We allow class‐dependent rejection and backlogging costs. We also incorporate holding costs and procurement costs. We obtain the optimal restocking and inventory dispensation policies under the total discounted cost criterion as well as the long‐run average cost criterion. In particular, we develop efficient algorithms to compute the optimal policies (OPs) by decoupling the inventory dispensation policy from the restocking policy. We show that the OP operates as follows: At the restocking epochs, we order up to a fixed base‐stock level. We satisfy the demands from a class if the inventory is above a critical level that depends on the class and time to the next restocking epoch; else we reject or backlog it depending on whether the next restocking epoch is later or earlier than a class‐dependent critical number. The numerical experiments for the stochastic and deterministic interstocking periods are conducted to compare the OPs and costs.
Pathogen inactivation treatment of triple‐dose apheresis platelets with amotosalen and ultraviolet a light
Authors: Infanti Laura , Pehlic Vildana , Mitrovic Sandra , Holbro Andreas , Andresen Silke , Payrat Jean‐Marc , Lin Jin‐Sying , Buser Andreas 
Published: September 2022

AbstractBackgroundA triple storage (TS) set allows for pathogen inactivation (PI) treatment of triple‐dose apheresis platelet products with amotosalen + UVA. We evaluated the quality and metabolic parameters of platelet concentrates (PCs) pathogen inactivated and stored for 7 days.Materials and methodsTwelve triple‐dose products collected with two different apheresis platforms were treated with amotosalen+UVA. Products were split into three single‐dose units. Testing was made pretreatment, after splitting, at days 5 and 7 of storage.ResultsSingle‐dose PI PCs had a mean platelet content of 2.89 ± 0.35 x 1011. From baseline to day 7, pH remained stable (7.1 ± 0.1 vs. 7.0 ± 0.1), pO2 increased (11.3 ± 2.4 vs. 18.3 ± 3.5 kPa) as did LDH (201 ± 119 vs. 324 ± 203 U/L) and lactate (3.6 ± 1.7 vs. 12.1 ± 1.5 mmol/L) (all p < 0.01); pCO2 decreased (4.1 ± 0.8 vs. 1.5 ± 0.7 mmHg; p < 0.01) and so did bicarbonate (6.6 ± 1.1 vs. 2.5 ± 1.4 mmol/L), glucose (5.6 ± 1.2 vs. 0.4 ± 0.4 mmol/L) and ATP (3.4 ± 0.9 vs. 2.5 ± 1.4 nmol/108 platelets) (all p < 0.05).ConclusionTriple‐dose PCs processed with the TS sets fulfilled the quality requirements and displayed metabolic changes of expected extent during 7‐day storage.
Covid-19, Direitos Sociais Trabalhista e Jurisprudência da Crise
Authors: Dias Roberto , Tedesco Thomaz Fiterman 
Published: September 2022

O mundo passa por uma crise sanitária com reflexos econômicos imediatos e severos. O objetivo do ensaio é aferir se, em contextos econômicos de crise, o Supremo Tribunal Federal altera seu modo de decidir e, principalmente, se já o está alterando nos casos envolvendo a crise do novo coronavírus, aderindo ou não a uma “jurisprudência da crise”. Para tanto, será analisado o julgamento proferido na MC-ADIn 6363. A pesquisa será do tipo bibliográfica, por meio de pesquisa qualitativa doutrinária e jurisprudencial. Conclui-se pela possibilidade concreta de o Supremo, durante este período, continuar a aderir à postura pragmática.
Militarização da Saúde: Crise e as Relações Civis- Militares no Governo Bolsonaro
Authors: Kozicki Katya , Chueiri Vera Karam de , Silva Rick Daniel Pianaro da , Bonatto Marina 
Published: September 2022

O presente artigo discute o processo de militarização do governo federal no campo da saúde pública e sua relação com a crise da democracia constitucional brasileira. Parte da premissa de que as Forças Armadas não detêm o conhecimento técnico para a gestão das atividades às quais seus integrantes têm sido designados no combate da pandemia do COVID-19. A sua primeira parte apresenta os referenciais teóricos que permitem identificar a crise da democracia constitucional. A segunda parte discute os vestígios do passado autoritário ainda presentes no constitucionalismo brasileiro, como a proibição fraca dos militares participarem na política. A terceira parte discute a politização das Forças Armadas na América Latina e seus riscos. A quarta parte trata especificamente da militarização da saúde no Brasil recente. Por fim, conclui que a militarização do atual governo e a consequente politização da caserna, no que diz respeito à saúde e no contexto da pandemia de covid-19, comprometem a democracia constitucional, na medida em que privilegiam nomeações de militares para diferentes cargos políticos e administrativos no Executivo Federal, a despeito da especialidade técnica, inclusive para o comando de estatais e ministérios não relacionados à defesa. A pesquisa se vale de fontes teóricas (livros e artigos) para a discussão do tema central proposto e também de fontes jornalísticas e informações disponibilizadas pelo próprio governo federal, em virtude da contemporaneidade do tema. O artigo é tanto prescritivo quando descritivo em suas premissas e análises.
Aspectos jurídicos da pandemia do Covid-19 e a atuação do Supremo Tribunal Federal em habeas corpus
Authors: Moraes Helena Brandão Nogueira de Oliveira , Vasconcellos Vinicius Gomes de 
Published: September 2022

Este artigo pretende analisar as decisões proferidas pelo Supremo Tribunal Federal em sede de habeas corpus catalogados como relacionados à situação de pandemia do Covid-19 com o objetivo de verificar se tal cenário determinou uma postura de desencarceramento, nos termos do reconhecido estado de coisas inconstitucional (ADPF 347) e da Recomendação 62 do CNJ. A partir do levantamento e exame das decisões concessivas proferidas no mês de abril de 2020 (concedidas no mérito ou liminares deferidas), questionou-se: a situação de pandemia do Covid-19 e a Recomendação 62 do CNJ ocasionaram impacto nas decisões do STF em habeas corpus? Constatou-se que não houve um impacto relevante na postura decisória dos Ministros do Supremo Tribunal Federal a partir do cenário de pandemia do Covid-19 e da Recomendação 62 do CNJ, pois entre 884 decisões assim catalogadas e proferidas no referido período somente 6 (seis) foram concessões com efetiva substituição da prisão por domiciliar em razão de riscos da pandemia do Covid-19, nos termos da Recomendação 62 do CNJ.
Results and SWOT Analysis of the 2022 Hong Kong Report Card on Physical Activity for Children and Adolescents With Special Educational Needs
Authors: Sit Cindy H.P. , Huang Wendy Y.J. , Wong Stephen H.S. , Wong Martin C.S. , Sum Raymond K.W. , Li Venus M.H. 
Published: September 2022

Background: Following the 2019 Hong Kong Para Report Card, the 2022 Hong Kong Para Report Card aimed to provide an updated and evidence-based assessment for nine indicators related to physical activity in children and adolescents with special educational needs and to assess the results using a SWOT (strengths, weaknesses, opportunities, and threats) analysis. Methods: Using a systematic process, the best available data on nine indicators were searched from the past 10 years and were assessed by a research work group. Letter grades were assigned and considered by stakeholders and auditors. Results: Four indicators were assigned a letter grade (overall physical activity: F [mixed device-measured and self-reported data]; sedentary behaviors: D [device-measured data]; active transportation: D−; government strategies & investment: C+). SWOT analysis highlighted opportunities for facilitating children and adolescents with special educational needs to achieve health recommendations. Conclusion: There were deteriorating trends in physical activity and sedentary behaviors. Effective, multilevel, and cross-sector interventions are recommended to promote active behavior in children and adolescents with special educational needs.
Is Real-Time Poolside Assessment of Upper Limb Errors in Front Crawl Swimming Technique Reliable and Equivalent to Video Analysis?
Authors: Pollen Travis R. , Ebaugh David , Mohring Jason , Hutchinson Dean , Silfies Sheri P. 
Published: September 2022

Context: Swimming technique is widely believed to influence performance, but this relationship has rarely been tested objectively using a real-time poolside assessment. Objective: To determine the (1) test–retest reliability, interrater reliability, and criterion validity (live vs video) of real-time poolside assessment of upper limb (UL) errors in front crawl (FC) swimming technique and (2) the relationship between UL errors and FC swimming performance. Design: Cross-sectional reliability, validity, and correlational study. Setting: Swim team practice at a college natatorium. Participants: Thirty-nine Division III college swimmers (21 women and 18 men, age = 19 [1] y, swimming experience = 11 [3] y). Main Outcome Measures: Seven UL errors in FC swimming technique, many of which involved unnecessary vertical and mediolateral motions, were assessed in real time from outside the pool during swim practice. Test–retest reliability, interrater reliability, and criterion validity were calculated using Cohen kappa (κ) and weighted kappa (κw). Swimming performance was determined by the participants’ best FC events relative to the conference records. The correlation between total UL errors and FC swimming performance was assessed with Pearson r. Results: Cohen κ and κw were moderate for the majority of errors, with the following ranges: 0.46 to 0.90 (test–retest), −0.01 to 1.00 (interrater), and 0.36 to 0.66 (criterion validity). There was a significant correlation between total UL errors and FC swimming performance: r(24) = −.59 (P = .001, R2 = .35). Conclusions: Reliability and validity were moderate for the majority of errors. The fewer UL errors swimmers made while practicing FC, the faster their best FC race times tended to be relative to the conference record. UL errors in FC swimming technique explained 35% of the variance in performance.
Smartphone-based Ecological Momentary Intervention for secondary prevention of suicidal thoughts and behaviour: protocol for the SmartCrisis V.2.0 randomised clinical trial
Authors: Barrigon Maria Luisa , Porras-Segovia Alejandro , Courtet Philippe , Lopez-Castroman Jorge , Berrouiguet Sofian , Pérez-Rodríguez María-Mercedes , Artes Antonio ,   MEmind Study Group, Baca-Garcia Enrique 
Published: September 2022

IntroductionSuicide is one of the leading public health issues worldwide. Mobile health can help us to combat suicide through monitoring and treatment. The SmartCrisis V.2.0 randomised clinical trial aims to evaluate the effectiveness of a smartphone-based Ecological Momentary Intervention to prevent suicidal thoughts and behaviour.Methods and analysisThe SmartCrisis V.2.0 study is a randomised clinical trial with two parallel groups, conducted among patients with a history of suicidal behaviour treated at five sites in France and Spain. The intervention group will be monitored using Ecological Momentary Assessment (EMA) and will receive an Ecological Momentary Intervention called ‘SmartSafe’ in addition to their treatment as usual (TAU). TAU will consist of mental health follow-up of the patient (scheduled appointments with a psychiatrist) in an outpatient Suicide Prevention programme, with predetermined clinical appointments according to the Brief Intervention Contact recommendations (1, 2, 4, 7 and 11 weeks and 4, 6, 9 and 12 months). The control group would receive TAU and be monitored using EMA.Ethics and disseminationThis study has been approved by the Ethics Committee of the University Hospital Fundación Jiménez Díaz. It is expected that, in the near future, our mobile health intervention and monitoring system can be implemented in routine clinical practice. Results will be disseminated through peer-reviewed journals and psychiatric congresses. Reference number EC005-21_FJD. Participants gave informed consent to participate in the study before taking part.Trial registration numberNCT04775160.
White cell count trajectory and type 2 diabetes in health management population: a retrospective cohort study
Authors: Yang Tengfei , Zhao Bo , Guan Xuelai , Pei Dongmei 
Published: September 2022

ObjectiveThe purposes of current research were to investigate the time-dependent dynamic alteration of white cell count (WCC) in health management populations and to analyse its association with the type 2 diabetes mellitus (T2DM).DesignRetrospective cohort research.SettingShengjing Hospital of China Medical University in China’s Shenyang.ParticipantsThe number of non-diabetic subjects (median age: 40 years) totaled 7924 in the present work.Primary and secondary outcome measuresAssessment and grouping of changes in WCC between 2016 and 2019 were accomplished through group-based trajectory modelling. Newly diagnosed incidence associated with T2DM was estimated based on varying trajectories of WCC by the Kaplan-Meier method. Statistical differences in the incidences of new-onset T2DM among various WCC trajectory groups were examined through log-rank test. The influence of WCC trajectory alterations on the new-onset T2DM was evaluated with a multiparameter Cox (proportional-hazards) model.ResultsDuring a 3-year (2016–2019) period, the T2DM development was noted in 3.14% (249) of the subjects. The trajectory model of WCC change was divided into four groups. For participants with low stability (trajectory 1), medium stability (trajectory 2), medium stability (trajectory 3) and high stability (trajectory 4), the incidence of T2DM was separately 2.2%, 2.62%, 4.82% and 7.4%, respectively. After adjusting for the underlying confounders, new-onset T2DM HRs (95% CIs) for trajectories 3 and 4 were separately 1.94 (1.32 to 2.83) and 3.08 (1.82 to 5.21) compared with the trajectory 1, implying that the T2DM risks were statistically significantly high.ConclusionThe 3-year T2DM incidence was impacted independently by the WCC trajectory fluctuations. The grouping trajectory can reflect the dynamic change of WCC over time, which is more representative than the measured WCC at a single time point.
Orang Asli Health and Lifeways Project (OA HeLP): a cross-sectional cohort study protocol
Authors: Wallace Ian J , Lea Amanda J , Lim Yvonne A L , Chow Steven K W , Sayed Izandis bin Mohd , Ngui Romano , Shaffee Mohd Tajudin Haji , Ng Kee-Seong , Nicholas Colin , Venkataraman Vivek V , Kraft Thomas S 
Published: September 2022

IntroductionNon-communicable disease (NCD) risk is influenced by environmental factors that are highly variable worldwide, yet prior research has focused mainly on high-income countries where most people are exposed to relatively homogeneous and static environments. Understanding the scope and complexity of environmental influences on NCD risk around the globe requires more data from people living in diverse and changing environments. Our project will investigate the prevalence and environmental causes of NCDs among the indigenous peoples of Peninsular Malaysia, known collectively as the Orang Asli, who are currently undergoing varying degrees of lifestyle and sociocultural changes that are predicted to increase vulnerability to NCDs, particularly metabolic disorders and musculoskeletal degenerative diseases.Methods and analysisBiospecimen sampling and screening for a suite of NCDs (eg, cardiovascular disease, type II diabetes, osteoarthritis and osteoporosis), combined with detailed ethnographic work to assess key lifestyle and sociocultural variables (eg, diet, physical activity and wealth), will take place in Orang Asli communities spanning a gradient from remote, traditional villages to acculturated, market-integrated urban areas. Analyses will first test for relationships between environmental variables, NCD risk factors and NCD occurrence to investigate how environmental changes are affecting NCD susceptibility among the Orang Asli. Second, we will examine potential molecular and physiological mechanisms (eg, epigenetics and systemic inflammation) that mediate environmental effects on health. Third, we will identify intrinsic (eg, age and sex) and extrinsic (eg, early-life experiences) factors that predispose certain people to NCDs in the face of environmental change to better understand which Orang Asli are at greatest risk of NCDs.Ethics and disseminationApproval was obtained from multiple ethical review boards including the Malaysian Ministry of Health. This study follows established principles for ethical biomedical research among vulnerable indigenous communities, including fostering collaboration, building cultural competency, enhancing transparency, supporting capacity building and disseminating research findings.
Clinical characteristics of ocular myasthenia gravis and outcomes of secondary generalisation: a systematic review protocol
Authors: Fang Clarissa E H , Bokre Desta , Wong Sui H 
Published: September 2022

ObjectiveWe aim to systematically assess the clinical characteristics of ocular myasthenia gravis (OMG) and report on the proportion of patients who develop secondary generalised myasthenia gravis (SGMG).IntroductionOMG is an autoimmune neuromuscular junction disorder resulting in ptosis and diplopia. A proportion of patients with OMG develop weakness in their limbs, respiratory or bulbar muscles, that is, convert to SGMG. The proportion of patients converting to SGMG reported in the literature have been varied. We therefore aim to systematically assess the clinical characteristics of OMG and outcomes of SGMG reported in the literature to date.Inclusion criteriaStudies describing a population of adults with OMG, that is, MG with ocular symptoms and signs only, seen consecutively through a clinical service, reporting on patient characteristics and the outcome of SGMG. Studies on paediatric and congenital myasthenia gravis will be excluded.MethodsWe will conduct an electronic database search for randomised controlled trials, prospective non-randomised studies, observational studies and retrospective studies in MEDLINE, Embase, Cochrane Central Register of Controlled Trials and Web of Science. Exploratory database search was conducted on 1 December 2021. Eligibility criteria will include quantitative and qualitative articles written in any language and containing data on OMG. Additional studies will be identified by reviewing bibliographies of retrieved articles. Two independent reviewers will screen titles and abstracts and extract data from full texts, reporting outcomes according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Data extraction of key characteristics will be completed using customised forms. Methodological quality will be assessed using the Joanna Briggs Institute critical appraisal forms.Ethics and disseminationEthical approval is not required for this review, as it will only include published data. Findings will be published in a peer-reviewed journal and disseminated across ophthalmic networks.PROSPERO registration numberCRD42021285257.
Effect of a programme of muscular endurance, balance and gait exercises with and without the use of flexible and minimalist shoes in older women with medial knee osteoarthritis: study protocol for a randomised controlled trial
Authors: Pereira Daniel Borges , Souza Tatiane Silva de , Fuzinato Carolina Tayama , Hagihara Rodrigo Jugue , Ribeiro Ana Paula 
Published: September 2022

IntroductionStudies have indicated that gait intervention programmes with minimalist shoes are effective for reducing pain, improving functionality and reducing knee joint overload in older women with knee osteoarthritis (OA). Other clinical trials with knee and foot muscle strength training and/or dynamic balance training have also shown clinical and functional effectiveness. Despite promising strategies, there is no evidence of the combination of shoes with gait intervention programmes. Thus, the objective of this randomised clinical trial is to investigate the effects of therapeutic programme of muscular resistance, balance and gait exercises with and without the use of low-cost, flexible shoes on the clinical, functional and biomechanical aspects of older women with medial knee OA.Methods and analysisThis randomised controlled trial with blinded evaluators will involve 36 older women. Twenty-four older women with knee OA (medial compartment) will be randomised to the intervention groups with minimalist shoes (GIC; n=12) or in a barefoot condition (GID; n=12), and 12 older women to the control group (n=12). The intervention protocol will consist of knee-foot muscle resistance and static balance training, reactive and proactive dynamic balance training, and gait training with visual feedback. The intervention will have a duration of two consecutive months, twice a week, totalling 16 sessions. The primary outcomes will be walking pain measured by Visual Analogue Scale and questionnaires: Western Ontario McMaster Universities Osteoarthritis Index and Lequesne Algofunctional. The secondary outcomes will be: 6-min walk test, Falls Risk Awareness Questionnaire, Timed Up and Go Test, and distribution of plantar load during gait and balance by pressure platform. Data will be analysed according to an intention-to-treat approach.Ethics and disseminationThis study involves human participants and was approved by the ethics committee of the Universidade Santo Amaro, School Medicine, São Paulo/SP, Brazil (N°4.091.006). Participants gave informed consent to participate in the study before taking part. Investigators will communicate trial results to participants and healthcare professionals through scientific databases, social media, publications and conferences.Trial registration numberRBR-10j4bw25 in Brazilian Clinical Trial Registry.