bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sex‐specific metabolic signatures in methamphetamine addicts
Authors: Cheng Zhen , Peng Yaqin , Wen Jun , Chen Wenwen , Pan Weichao , Xu Xing , Lu Xue , Cai Qinglong , Ge Feifei , Fan Yu , Wang Jun , Guan Xiaowei 
Published: November 2022

AbstractMethamphetamine (METH) is a commonly abused addictive psychostimulant, and METH‐induced neurotoxic and behavioural deficits are in a sex‐specific manner. However, there is lack of biomarkers to evaluate METH addiction in clinical practice, especially for gender differences. We utilized ultra‐high‐performance liquid chromatography–tandem mass spectrometry (UHPLC–MS/MS) to detect the serum metabolomics in METH addicts and controls, specially exploring the sex‐specific metabolic alterations by METH abuse. We found that many differently expressed metabolites in METH addicts related to metabolisms of amino acid, energy, vitamin and neurological disorders. Further, METH abuse caused different patterns of metabolomics in a sex‐specific manner. As to amino acid metabolism, L‐phenylalanine, L‐tryptophan and L‐histidine in serum of male addicts and betaine in serum of female addicts were significantly changed by METH use. In addition, it seemed that purine and pyrimidine‐related metabolites (e.g., xanthosine and adenosine 5′‐monophosphate) in male and the metabolites of hormone (e.g., cortisol) and folate biosynthesis (e.g., 7,8‐dihydrobiopterin and 4‐hydroxybenzoic acid) in female were more sensitive to METH addiction. Our findings revealed that L‐glutamic acid, L‐aspartic acid, alpha‐ketoglutarate acid and citric acid may be potential biomarkers for monitoring METH addiction in clinic. Considering sex‐specific toxicity by METH, the metabolites of purine and pyrimidine metabolism in male and those of stress‐related hormones in female may be used to facilitate the accurate diagnosis and treatment for METH addicts of different genders.
A comparative interventional study of narrowband ultraviolet B alone and narrowband ultraviolet B in combination with microneedling in patients with stable vitiligo
Authors: Kaur Aneet , Barman Krishna Deb , Sahoo Bijaylaxmi , Choudhary Priya 
Published: November 2022

AbstractBackgroundVitiligo is a cosmetically concerning common disorder of depigmentation. Narrowband Ultraviolet B (NB‐UVB) phototherapy is a well‐established mode of treatment for vitiligo. Microneedling is a simple method that has been used for vitiligo treatment in adjunct with NB‐UVB and has been shown to induce repigmentation in a few studies; however, there is limited study in the literature.AimsTo compare the efficacy of NB‐UVB alone versus NB‐UVB in conjunction with microneedling in patients of stable vitiligo.MethodsThirty patients of non‐segmental vitiligo with patches tending toward symmetry, stable for at least 6 months were included. Patches on right side of body (side A) were subjected to both microneedling every 2 weeks and NB‐UVB three times a week, while patches on left side of body (side B) were subjected to NB‐UVB alone thrice weekly for 4 months or till complete resolution of lesions whichever was earlier. Patients were followed up for another 2 months. Response was assessed by photographic record and Vitiligo Area Severity Index (VASI score) calculated at baseline and every month for 6 months.ResultsThe mean VASI score improvement in both the groups as compared to baseline was statistically significant (p‐value < .01). However, the difference in mean VASI scores between the two groups was not statistically significant (p‐value = .17).ConclusionNB‐UVB is an effective modality for treatment of vitiligo, but there is no additional benefit of combining microneedling with it.
Neuromorphic Engineering: In Memory of Misha Mahowald
Authors: Mead Carver 
Published: November 2022

Abstract
We review the coevolution of hardware and software dedicated to neuromorphic systems. From modest beginnings, these disciplines have become central to the larger field of computation. In the process, their biological foundations become more relevant, and their realizations increasingly overlap. We identify opportunities for significant steps forward in both the near and more distant future.
Incidence and determinants of maternal sepsis in Ghana in the midst of a pandemic
Authors: Noora Charles Lwanga , Manu Adom , Addo-Lartey Adolphina , Mohammed Abdul Gafaru , Ameme Donne Kofi , Kenu Ernest , Torpey Kwasi , Adanu Richard 
Published: November 2022

Abstract
Background
Despite being preventable, maternal sepsis continues to be a significant cause of death and morbidity, killing one in every four pregnant women globally. In Ghana, clinicians have observed that maternal sepsis is increasingly becoming a major contributor to maternal mortality. The lack of a consensus definition for maternal sepsis before 2017 created a gap in determining global and country-specific burden of maternal sepsis and its risk factors. This study determined the incidence and risk factors of clinically proven maternal sepsis in Ghana.

Methods
We conducted a prospective cohort study among 1476 randomly selected pregnant women in six health facilities in Ghana, from January to September 2020. Data were collected using primary data collection tools and reviewing the client’s charts. We estimated the incidence rate of maternal sepsis per 1,000 pregnant women per person-week. Poisson regression model and the cox-proportional hazard regression model estimators were used to assess risk factors associated with the incidence of maternal sepsis at a 5% significance level.

Results
The overall incidence rate of maternal sepsis was 1.52 [95% CI: 1.20–1.96] per 1000 person-weeks. The majority of the participants entered the study at 10–13 weeks of gestation. The study participants' median body mass index score was 26.4 kgm−2 [22.9—30.1 kgm−2]. The risk of maternal sepsis was 4 times higher among women who developed urinary tract infection after delivery compared to those who did not (aHR: 4.38, 95% CI: 1.58–12.18, p < 0.05). Among those who developed caesarean section wound infection after delivery, the risk of maternal sepsis was 3 times higher compared to their counterparts (aHR: 3.77, 95% CI: 0.92–15.54, p < 0.05). Among pregnant women who showed any symptoms 14 days prior to exit from the study, the risk was significantly higher among pregnant women with a single symptom (aHR: 6.1, 95% CI: 2.42–15.21, p < 0.001) and those with two or more symptoms (aHR: 17.0, 95% CI: 4.19–69.00, p < 0.001).

Conclusions
Our findings show a low incidence of maternal sepsis in Ghana compared to most Low and Middle-Income Countries. Nonetheless, Maternal sepsis remains an important contributor to the overall maternal mortality burden. It is essential clinicians pay more attention to ensure early and prompt diagnosis. Factors significantly predicting maternal sepsis in Ghana were additional maternal morbidity, urinary tract infections, dysuria, and multiple symptoms. We recommend that Ghana Health Service should institute a surveillance system for maternal sepsis as a monthly reportable disease.
The Tower
Authors: Bradney Anthony 
Published: November 2022

The image of the tower is a potent symbol in many cultures. In the ‘Epilogue’ in Blackstone’s Tower, Twining referred to the Eiffel Tower with respect to his book. This article will instead look at the Tower of Babel, the concept of the ivory tower and the tower in which Montaigne composed his essays. It will ask what lessons universities and their law schools can learn from reflecting on these mythical and real towers.
Keywords: Tower of Babel; Montaigne’s Tower; ivory tower.
A National Emergency or a Public Health Crisis? Reflecting on the 2020 and 2021 Manx Responses to the Global Pandemic
Authors: Edge Peter W 
Published: November 2022

The Isle of Man, a self-governing Crown Dependency, developed its own response to the global pandemic, including strict border controls and periods of lockdown. In 2020, this was given legal effect through the declaration of a formal State of Emergency, while, in 2021, similar measures were implemented under public health legislation without a State of Emergency. Framing the 2021 lockdowns as a public health crisis led to a more tightly focused response than the 2020 framing as a national emergency. Within this narrower range, however, the structure of the public health legislation as implemented provided less democratic accountability than the emergency powers legislation and reduced the emphasis given to the rules as laws, leading to a decrease in formality in relation to both creation and publication of these legal rules, and exacerbating a blurring between law and advice. These disadvantages were not, however, intrinsic to the public health legislation itself, and if corrected the public health response is to be preferred.
Keywords: pandemic; State of Emergency; public health, Isle of Man.
Death, Burials and Funerals
Authors: Chan Hui Yun 
Published: November 2022

Covid-19 has radically upended death and dying. Restrictive measures aimed at containing the spread of infections have resulted in a simplification or abandonment of many social and cultural practices related to burials, funerals and mourning. This article aims to examine how the pandemic has affected burials, funeral practices and mourning. It analyses the extent to which the restrictions balance the need to protect public health and the opportunity for mourners to honour the deceased. A consideration of the implications for surviving families and the wider community is important for future pandemic preparations.
Keywords: pandemic; death; burial; funeral; grief; mourning.
Idiopathic Hypertrophy of Abductor Digiti Minimi Muscle: A Case Report
Authors: Jara Ana B. , Carrillo Manuela Quiroga , Ordóñez-Reyes Camila , Santos-Barros Martha , Mendoza Doris Ellianne , Montoya Diana Paola 
Published: November 2022

Abstract
Soft tissue masses of the foot are rare and diagnosis may be problematic. Surgical excision is the first-line treatment when a patient has discomfort, pain, or functional impairment. Few cases of hypertrophy of the abductor digiti minimi have been reported. To our knowledge, only four cases have been described in the literature. We present a case of a 6-year-old female patient diagnosed with hypertrophy of the abductor digiti minimi muscle of the left foot. We describe surgical treatment and clinical results after one year of follow-up.
Вариативность стратегий декарбонизации нефтегазовой индустрии
Authors: Блам И.Ю. , Ковалев С.Ю. 
Published: November 2022

В статье приводятся результаты сравнительного анализа климатических стратегий крупнейших нефтегазовых компаний мира. Показано, что целью декарбонизации они ставят не только сокращение выбросов парниковых газов, но и повышение конкурентоспособности, при этом их климатическая политика реализуется с учетом национальных особенностей и может существенно отличаться в зависимости от региона присутствия. В частности, описаны три типа декарбонизации – европейский, американский и российский.
Kepuasan Terapis Anak Berkebutuhan Khusus
Authors: Firdaus Muhammad Mirza , Imtitsal Rasyidah Umi 
Published: November 2022

Penelitian ini betujuan untuk mendeskripsikan kepuasan kerja terapis dalam memberikan treatment kepada anak berkebutuhan khusus. Pekerjaan ini melibatkan emosional yang cukup besar, kesabaran yang tinggi dan memiliki keperibadian yang baik. Jenis penelitian ini menggunakan penelitian kualitatif yaitu dengan penelitian yang berusaha menggambarkan objek yang diteliti berdasarkan fakta yang ada di lapangan. Metode pengumpulan data dalam penelitian ini menggunakan observasi dan wawancara mendalam dengan ke empat terapis yang telah lama bekerja lebih dari lima tahun dengan kategori usia 25-35 tahun. Hasil penelitian ini secara umum menunjukkan bahwa kepuasan kerja terapis disebabkan oleh kepedulian terapis, lingkungan kerja yang kondusif dan dukungan dari para orangtua atau wali murid yang berdampak pada kinerja yang stabil. Selain itu adanya jiwa kemanusiaan yang tinggi yang membuat keempat subjek dalam penelitian ini dapat bertahan hingga saat ini dan menjalankan profesinya sebagai terapis anak berkebutuhan khusus.
Kata kunci :Kepuasan kerja, orang terapis, anak berkebutuhan khusus
Selective internal radiation therapy of metastatic breast cancer to the liver: A meta-analysis
Authors: Liu Chenyu , Tadros George , Smith Quinn , Martinez Linda , Jeffries James , Yu Zhiyong , Yu Qian 
Published: November 2022

IntroductionThe aim of this study is to conduct a meta-analysis to assess the efficacy of yttrium-90 selective internal radiation therapy (SIRT) in treating patients with breast cancer with hepatic metastasis.MethodPubMed and The Cochrane Library were queried from establishment to January 2021. The following keywords were implemented: “breast”, “yttrium”, and “radioembolization”. The following variables and outcomes were collected: publication year, region, sample size, study design, presence of extrahepatic disease, tumor burden, infused radioactivity, breast cancer subtype, previous treatment, median survival time (MST), length of follow-up, adverse events, and radiographical response such as Response Evaluation Criteria in Solid Tumors (RECIST), modified RECIST (mRECIST), and Positron Emission Tomography Response Criteria in Solid Tumors (PERCIST).ResultsA total of 24 studies from 14 institutions were included in the present meta-analysis. On the basis of the data from 412 patients, post-embolization MST was 9.8 [95% confidence interval (CI): 9.0–11.6] months. Patients with additional extrahepatic metastasis had a poorer survival rate compared with those with localized hepatic metastasis only (MST: 5.3 vs. 15 months, p &lt; 0.0001). Patients with &lt;25% liver tumor burden exhibited more promising survival than those with &gt;25% (MST: 10.5 vs. 6.8 months, p &lt; 0.0139). On the basis of RECIST, mRECIST, and PERCIST criteria, tumor response rate was 36% (95% CI: 26%–47%), 49% (95% CI: 34%–65%), and 47% (95% CI: 17%–78%), respectively, whereas tumor control rate was 85% (95% CI: 76%–93%), 73% (95% CI: 59%–85%), and 97% (95% CI: 91%–100%), respectively.ConclusionOn the basis of the available published evidence, SIRT is feasible and effective in treating patients with breast cancer with liver metastasis. Patients with lower hepatic tumor burden and without extrahepatic metastasis demonstrated more survival benefit. Future randomized controlled trials are warranted.
Integrated spatial analysis of gene mutation and gene expression for understanding tumor diversity in formalin-fixed paraffin-embedded lung adenocarcinoma
Authors: Yamazaki Miki , Hosokawa Masahito , Matsunaga Hiroko , Arikawa Koji , Takamochi Kazuya , Suzuki Kenji , Hayashi Takuo , Kambara Hideki , Takeyama Haruko 
Published: November 2022

IntroductionA deeper understanding of intratumoral heterogeneity is essential for prognosis prediction or accurate treatment plan decisions in clinical practice. However, due to the cross-links and degradation of biomolecules within formalin-fixed paraffin-embedded (FFPE) specimens, it is challenging to analyze them. In this study, we aimed to optimize the simultaneous extraction of mRNA and DNA from microdissected FFPE tissues (φ = 100 µm) and apply the method to analyze tumor diversity in lung adenocarcinoma before and after erlotinib administration.MethodTwo magnetic beads were used for the simultaneous extraction of mRNA and DNA. The decross-linking conditions were evaluated for gene mutation and gene expression analyses of microdissected FFPE tissues. Lung lymph nodes before treatment and lung adenocarcinoma after erlotinib administration were collected from the same patient and were preserved as FFPE specimens for 4 years. Gene expression and gene mutations between histologically classified regions of lung adenocarcinoma (pre-treatment tumor in lung lymph node biopsies and post-treatment tumor, normal lung, tumor stroma, and remission stroma, in resected lung tissue) were compared in a microdissection-based approach.ResultsUsing the optimized simultaneous extraction of DNA and mRNA and whole-genome amplification, we detected approximately 4,000–10,000 expressed genes and the epidermal growth factor receptor (EGFR) driver gene mutations from microdissected FFPE tissues. We found the differences in the highly expressed cancer-associated genes and the positive rate of EGFR exon 19 deletions among the tumor before and after treatment and tumor stroma, even though they were collected from tumors of the same patient or close regions of the same specimen.ConclusionOur integrated spatial analysis method would be applied to various FFPE pathology specimens providing area-specific gene expression and gene mutation information.
The joint association of physical activity and sedentary behavior with metabolic syndrome among urban men aged 60+ years in regional China
Authors: Lou Qinglin , Wu Haidi , Li Guang , Hu Yan , Ye Qing , Gu Shouyong , Xu Fei 
Published: November 2022

ObjectivesMetabolic syndrome (MetS) is a major public health issue worldwide, which is preventable through physical activity (PA) promotion and sedentary behavior (SB) reduction. However, the joint association of PA and SB with MetS was not well-investigated, particularly in elderly people. This study aimed to examine separate and joint associations of PA and SB with MetS among elderly urban men in China.MethodsIn this cross-sectional study conducted in mid-2018, participants were urban men aged 60+ years randomly selected from in Nanjing of China. Exposure variables were PA and SB. The outcome variable was MetS. A participant was categorized as “having MetS” or “not having MetS” in the analysis. Independent variables were PA and SB, which were categorized as “sufficient PA or insufficient PA” and “shortened SB or prolonged SB”, respectively. Mixed-effects logistics regression models were applied to calculate odds ratios (ORs) and 95% confidence intervals (CIs) to assess the association of PA and SB with MetS.ResultsTotally, 5,520 from 5,792 eligible participants were randomly recruited and their mean age was 68.9 (standard deviation: 16.9) years. The prevalence of MetS was 30.8% (95%CI = 29.6%, 32.0%) among urban men aged 60+ years in the study. After adjustment for potential confounders, subjects with sufficient PA were less likely (OR = 0.77, 95%CI = 0.67, 0.88) to experience MetS, independently of SB, relative to their counterparts with insufficient PA, while a lower odds (OR = 0.74; 95%CI = 0.61, 0.89) of experiencing MetS was examined for participants with shortened SB, also independently of PA, compared to those with prolonged SB in the study. Furthermore, compared to participants with insufficient PA and prolonged SB, those either within categories of insufficient PA and shortened SB (OR = 0.81; 95%CI = 0.65, 0.99), sufficient PA and prolonged SB (OR = 0.80; 95%CI = 0.70, 0.92), or sufficient PA and shortened SB (OR = 0.41; 95%CI = 0.26, 0.63) were at significantly lower risk to experience MetS, respectively.ConclusionsPA was negatively associated with MetS, and SB was positively linked to MetS, which were independent of each other. Moreover, sufficient PA and shortened SB might exert additively joint influence on MetS. This study has important implications that concurrent PA promotion and SB reduction shall be encouraged for people to optimize the effectiveness of MetS prevention.
PENGARUH PERSEPSI HARGA DAN KUALITAS TERHADAP NIAT BELI ULANG PRODUK PRIVATE LABEL BRAND (NON-FOOD CATEGORY) DI TOSERBA YOGYA & GRIYA KOTA BANDUNG
Authors: Ratnafuri Riska Fitri , Gunawan Theresia , Istiharini Istiharini 
Published: November 2022

The purpose of this study is to analyze the effect of Perceived Price and Quality on Repurchase Intention for private label brand products (non-food category) at Yogya & Griya department stores, Bandung. This study uses 140 respondents who had purchased private label products (non-food category) twice in the last three months as sample consumers. The sampling used in this study is non-probability sampling technique. The method used is purposive sampling. This study uses questionnaire to collect data. Using the causal relationship method, it is employed the Validity Test, Reliability Test, the Classical Assumption Test, hypothesis test using the F test and t test, as well as analyze the Coefficient of Determination and Multiple Linear Regression. The result of this study shows that Perceived Price (X1) and Perceived Quality (X2) have a positive and significant effect on Repurchase Intention (Y), both partially and simultaneously, it can be said that Perceived Price and Quality are the determining factors in the Repurchase Intention of private label brand products (non-category), meaning that the higher the perceived price and quality, the more it will increase repurchase intention for private label brand products (non-food category).
Keywords: Private Label Brand, Perceived Price, Perceived Quality, Repurchase Intention
Peter Brook: Threads of Time
Authors: Brook Peter 
Published: November 2022

"First there was the master conjurer adept at musicals, farces, opera and Shakespeare. Then there was the philosopher-king … who has devoted his energies to a quest for a theatre that was simple in form and rich in meaning." - Michael Billington
The theatre's greatest contemporary director tells the story of his life. Peter Brook was the modern stage's greatest inventor. For over 50 years he held audiences spellbound with his critically acclaimed productions. This is his account of his life. Born in 1925 in London, at 21 Brook became the enfant terrible of British theatre, directing major post-war productions of Shakespeare at Stratford-upon-Avon, opera at Covent Garden and new plays in London's West End. He even made films. In 1964 he produced Peter Weiss's Marat/Sade for the RSC and his whole approach to theatre became radicalised. Throughout the 1970s and 1980s Brook began exploring the roots of non-Western theatre which once again changed his view of what theatre could be for actors and audiences. His journey took him to Paris where he founded a company at the Bouffes du Nord theatre. Brook's autobiography charts all the stages of his aesthetic and spiritual journey, and touches on all parts of a career that has been widely reported but never previously talked about from his personal perspective.
Emerging cures for cancer: peptides from scorpion and spider venom
Authors: He Jiayi , Xue Yedong 
Published: November 2022

Animal toxins have shown applicability in treatments of various diseases, here some investigations of scorpion and spider venom peptides as cancer treatments have been presented. Scorpion peptides are believed to have antitumor and analgesic effects and may present the potential to be applied in human medicine as a drug for cancer. Similarly, some spider peptides either directly or indirectly are also proved to regulate tumour cell growth and death. Mechanism involved includes promoting cell apoptosis to prevent translocation of cancer cells thus control tumour growth. Such effects make these peptides promising drug candidates for cancer treatment. All five of scorpion venom peptide drugs being approved by FDA for clinical treatment, from which remarkable treating outcomes have been observed when treating cancers. In this paper, general aspects of different scorpion venoms as well as their anticancer mechanism have been thoroughly analysed, from which the successful application of Buthus martensii Karsch analgesic peptide in treating carcinoma was elected as the representative case.