bluuebunny/crossref_metadata_2025_split huggingface dataset:
Antibacterial Activity of Pineapple Peel (Ananas comosus) Eco-enzyme Against Acne Bacterias (Staphylococcus aureus and Prapionibacterium acnes)
Authors: Ramadani Aisyah Hadi , Karima Rizkya , Ningrum Riska Surya 
Published: April 2022

Acne (acne vulgaris) is a skin disease caused by infection or inflammation of the pilosebaceous unit. Staphylococcus aureus and Prapionibacterium acnes was the main actor in the infection. Eco-enzyme that is made from pineapple peel has been stated that have inhibitory activity against gram-positive and negative bacteria, also applied as home industry soap. This study objective as scientific support that Eco-enzyme phytochemical compounds had the antibacterial activity to the acne bacteria. Eco-enzyme was composed of pineapple peel, brown sugar, and water with the ratio of 3:1:10 for 3 months fermentation time. Eco-enzyme was screened of its phytochemical compound and antibacterial activity against S.aureus and P.acnes by dilution with various concentrations (1.5625%, 3, 125%, 6.25%, 12.5%, 25%, and 50% v/v) and various control. The minimum inhibition concentration (MIC) was then tested by diffusion method to determine the inhibition zone with 3 replication using the higher concentration (50%, 75%, 100% v/v). The result showed that eco-enzyme has a clear yellow colour, contains tannin and saponin, MIC of S.aureus and P.acnes bacteria is 50%. The dilution test of eco-enzyme gives the most effective concentration to inhibit S.aureus at eco-enzyme 100% (v/v), contrasted to P. acnes which didn’t show the best inhibition concentration.
Environments. Actions of Adaptation in Architecture
Authors: Ulber Marie , Mahall Mona , Serbest Asli 
Published: April 2022

The 1960s Environments emerged as artistic practices to question our modern relationship to objects perceived as isolated entities and as products within a market logic; to context, initiative, authority, ethics, and aesthetics. As open, process-based situations, they should allow for a praxis of reappraising demarcations, roles, and concepts in the art, social, and natural world. Environments had an early, but only short influence. To this day, art and architecture continue to be widely shaped by objectifying and reifying processes, even though the limits of the systems they belong to have become obvious in confrontation with a global climate crisis.In this article, the authors re-connect to the earlier artistic and architectural practices with the aim to develop a conceptual approach to adaptive architecture. This architecture is conceived as part of open “Environments", able to dynamically react with their users to social and environmental challenges, to mediate and reframe the relations between subjects, objects, and the natural world.
ВЛАСТИВОСТІ КЛАСІВ ЦІЛИХ НА ЗРІЗКАХ ФУНКЦІЙ ТА ФУНКЦІЙ ГОЛОМОРФНИХ НА ЗРІЗКАХ В ОДИНИЧНІЙ КУЛІ
Authors: Бандура А. І. , Шегда Л.М. 
Published: April 2022

У цій статті досліджуються властивості класу цілих на зрізках функцій декількох комплексних змінних, тобто функцій, що є цілими на кожній зрізці вигляду $\{z^0+t\mathbf{b}: t\in\mathbb{C}\}$ для довільного $z^0\in\mathbb{C}^n$ і для фіксованого напрямку $\mathbf{b}\in\mathbb{C}^n\setminus\{\mathbf{0}\}$. Для функції $F$ з такого класу вводяться функція зрізки $g_z(t)=F(z+t\mathbf{b})$ $(z\in\mathbb{C}^n,$ $t\in\mathbb{C})$ та похідна за напрямком $\partial_{\mathbf{b}}F(z):=g'_z(0),$ $\partial^p_{\mathbf{b}}F(z):=\partial_{\mathbf{b}}(\partial_{\mathbf{b}}^{p-1}F(z)),$ $p\ge 2.$ Показуємо, що якщо неперервна за сукупністю змінних функція $F$ належить до цього класу, то для будь-якого $p\in\mathbb{N}$ функція $\partial_{\mathbf{b}}^p F$ також належить до того самого класу і також неперервна за сукупністю змінних. Подібний результат також встановлений для функцій, що голоморфні на зрізках в одиничній кулі.
Endoscopic strip craniectomy with orthotic helmeting for safe improvement of head growth in children with Apert syndrome
Authors: Riesel Johanna N. , Riordan Coleman P. , Hughes Christopher D. , Karsten Madeline B. , Staffa Steven J. , Meara John G. , Proctor Mark R. 
Published: April 2022

OBJECTIVE
Bilateral coronal craniosynostosis in Apert syndrome is traditionally managed with open cranial vault remodeling procedures like fronto-orbital advancement (FOA). However, as minimally invasive procedures gain popularity, limited data exist to determine their efficacy in this syndromic population. This study examines whether endoscopic strip craniectomy (ESC) is inferior to FOA in correcting head growth in patients with Apert syndrome.

METHODS
The authors conducted a retrospective review of children with Apert syndrome over a 23-year period. Postoperative head circumferences until 24 months of age were compared for patients treated with ESC versus FOA by using normative growth curves. Intraoperative and postoperative morbidity was compared between groups.

RESULTS
The median postoperative follow-up for the FOA (n = 14) and ESC (n = 16) groups was 40 and 28.5 months, the median age at operation was 12.8 and 2.7 months, and the median operative time was 285 and 65 minutes, respectively (p < 0.001). The FOA group had significantly higher rates of blood transfusion, ICU admission, and longer hospital length of stay (p < 0.01). There were no statistically significant differences in premature reossification rates, complications, need for further procedures, or complaints of asymmetry. Compared to normative growth curves, all patients in both groups had head circumferences comparable to or above the 85th percentile at last follow-up.

CONCLUSIONS
Children with Apert syndrome and bilateral coronal craniosynostosis treated with ESC experience early normalization of head growth and cephalic index that is not inferior to those treated with FOA. Longer-term assessments are needed to determine long-term aesthetic results and the correlation between head growth and neurocognitive development in this population.
The improvement of daily fatigue in women following the intake of maca (Lepidium meyenii) extract containing benzyl glucosinolate
Authors: Honma Atsushi , Fujiwara Yumi , Takei Shin , Kino Takao 
Published: April 2022

Background: Daily fatigue is a problem for many people because of its association with other illnesses. Maca has lately attracted considerable attention as a food for recovering from fatigue. Maca is high in benzyl glucosinolate which improves endurance capacity by preventing glycogen depletion. However, its effect on fatigue has not been investigated in clinical trials on humans.Objective: The main objective of this study is to investigate the effects of maca supplements on reducing fatigue.Methods: This study evaluated the effect of the consumption of maca extract containing benzyl glucosinolate (9.6 mg/day) on fatigue in adult women. This randomized, placebo–controlled, parallel–group double–blind study enrolled 60 subjects who were allocated to consume maca extract or placebo for 4 weeks. A visual analogue scale (VAS) for fatigue was used to evaluate the results. Blood variables and adverse events were used to assess safety.Results: In both groups, the VAS of fatigue was decreased after 4 weeks compared with that before consumption. On stratification analysis, in subjects younger than 45 years, the VAS was significantly lower in the maca group, and the change between before and after supplementation was significantly larger in this group. Conclusions: It was suggested that intake of maca extract containing benzyl glucosinolate may have anti–fatigue effects in young women. So, maca supplements containing benzyl glucosinolate represent a food and drug candidate for reducing fatigue.Keywords: maca, Lepidium meyenii, benzyl glucosinolate, daily fatigue, visual analogue scale
Tumor-associated CD3- and CD8-positive immune cells in colorectal cancer: The additional prognostic value of CD8+-to-CD3+ ratio remains debatable
Authors: Kasurinen Jussi , Hagström Jaana , Kaprio Tuomas , Beilmann-Lehtonen Ines , Haglund Caj , Böckelman Camilla 
Published: April 2022

BACKGROUND: A large number of infiltrating CD3- and CD8-positive inflammatory cells indicates an improved survival in colorectal cancer (CRC), similar to many other cancers. OBJECTIVE: We investigated the prognostic value of different combinations of CD3- and CD8-positive immune cells in CRC patients. METHODS: The densities of CD3- and CD8-positive cells in intratumoral and stromal tissues were evaluated from 539 patients, for which we calculated a CD3 tumor–stroma index, a CD8 tumor–stroma index, and a CD3–CD8 tumor–stroma index. RESULTS: High CD3 and CD8 tumor–stroma indices associated with stage I to II disease ( p <  0.001 for both). The CD3 tumor–stroma index associated with a colonic tumor location ( p = 0.006), while the CD8 tumor–stroma index associated with right-sided tumors ( p <  0.001) and histological grade 3 tumors ( p = 0.032). High intratumoral and stromal densities for CD3- and CD8-positive immune cells, the CD3 tumor–stroma index, the CD8 tumor–stroma index, and the CD3–CD8 tumor–stroma index all indicated a better DSS. CONCLUSIONS: The CD3 tumor–stroma index carries a strong prognostic value in CRC, and none of the CD3 and CD8 combinations we analyzed proved superior.
Pengembangan Modul Pembelajaran dengan Pendekatan Problem Based Learning untuk Meningkatkan Hasil Belajar Siswa
Authors: Mundus Matriyanus Ardinius , Sefaverdiana Putri Vina , Rakhmadian Miftah 
Published: April 2022

Modul diartikan sebagai media untuk belajar mandiri karena di dalamnya telah dilengkapi petunjuk untuk belajar sendiri. Artinya, pembaca dapat melakukan kegiatan belajar tanpa kehadiran pengajar secara langsung yang dipadu oleh media modul sehingga mempermudahkan pesera didik untuk belajar kapan dan dimanapun saja. Jenis pengembangan yang digunakan dalam penelitan ini adalah pengembangan atau Research and Development. Alasan peneliti memilih jenis pengembangan ini karena pengembangan merupakan suatu metode penelitian yang digunakan untuk menghasilkan produk tertentu.Hal ini relevan dengan tujuan peneliti yang ingin menghasilkan suatu produk yang valid, praktis, dan efektif, berupa modul. Penelitian dan pengembangan ini berdasarkan model pengembangan yang dipilih, yaitu model pengembangan 4D yang dikembangkan oleh S. Thiagarajan. Model pengembangan 4D terdiri atas empat tahap yaitu: 1) Define, 2) Design, 3) Development dan 4) Disseminate. Produk yang di hasilkan berupa pengembangan modul pembelajaran dengan pendekatan Problem Based Learning untuk meningkatkan hasil belajar siswa Kelas VIII SMP Ibnu Sina. Berdasarkan hasil validasi oleh ke dua ahli yang pertama ahli materi diperoleh skor 92,64 dan ahli media dengan skor 83,92 dari nilai diatas dapat disimpulkan bahwa modul pelaku ekonomi masuk ke kategori sangat layak dan sudah bisa di implementasikan ke siswa siswi SMP.
STRATEGI ELIT DAN PARTISIPASI MASYARAKAT DALAM PENYELENGGARAAN PILKADA MUNA TAHUN 2020
Authors: Sarniati Sarniati , Dirman La Ode , Bahtiar Bahtiar 
Published: April 2022

Abstract: The purpose of this research is to identify, analyze and understand the Elite strategies, community participation and the implications of elite strategies and community participation on the results of the Regional Election. The theory used in this research is the theory of social practice by Pierre Bourdieu, methodologically this research is a qualitative research by collecting the data using observation and in-depth interviews technique. The results of this study indicate that the TERBAIK candidate pair fully empowers political elites and party elites in socializing to become campaign teams, empowers volunteer teams and approaches religious elites and civil elites. The pair of candidates for TERBAIK has also built good communication so that they have the full support of two former Muna Regents who still have a strong mass among the Muna community, namely the former Muna Regent for the 2000-2010 period and the former Muna Regent for the 2010-2015 period and other bureaucratic elites in Muna Regency. While the RAPI candidate pair did not empower the political elite and their supporting/supporting parties in socializing, the RAPI candidate pair maximized the teams and volunteers that were formed long before the Regional Election stage began and approached the religious elite and the civil elite. Several traditional and religious leaders were involved in practical politics so that there was disharmony between communities after the determination of the winner. The increasing political participation in the Regional Election is because apart from the vigur of the two pairs of candidates, alsi because of material rewards. In winning a candidate pair, the communication that is built is unconsciously influenced by history and the agreement of the Ancestors, affected by the district (ghoera) and social stratification (kaomu and walaka). Keywords: Community Participation, Elite Strategy, Implications, Regional Election Results
Coagulation Profile in COVID-19 Patients and its Relation to Disease Severity and Overall Survival: A Single-Center Study
Authors: Abd El-Lateef Amal Ezzat , Alghamdi Saad , Ebid Gamal , Khalil Khalid , Kabrah Saeed , Abdel Ghafar Muhammad Tarek 
Published: April 2022

Objectives: This study aims to investigate hemostatic changes in patients with coronavirus disease (COVID-19) and their relationship to disease severity and survival.Methods: This study included 284 patients with COVID-19 who attended the Security Forces Hospital, Makkah, Saudi Arabia between October 2020 and March 2021, and retrospectively reviewed their demographic, radiological, and laboratory findings. The coagulation profile was assayed at the time of diagnosis for platelet counts using an automated hematology analyzer; Sysmex XN2000 while international normalized ratio (INR), activated partial thromboplastin time (aPTT), fibrinogen, D-dimer, factor VIII, ristocetin cofactor (RiCoF), and von Willebrand factor antigen (VWF-Ag) were measured by Stago kits on a Stago automated coagulation analyzer (STA Compact Max®).Results: In this study, 32.3% of the cases had severe disease, while 8.8% of the cases died. D-dimer, factor VIII, and RiCoF were the only independent predictors of disease severity, with factor VIII and RiCoF having significantly higher areas under the curve (AUCs) than D-dimer (all p &lt; 0.001). Furthermore, age, aPTT, and factor VIII were associated with an increased risk of mortality in multivariate Cox regression analysis, with factor VIII having a higher AUC of 0.98 than aPTT with an optimal cut-off value of &gt;314 IU/dl in predicting mortality. Cases with factor VIII levels &gt;314 IU/dl, compared to those with factor VIII levels &lt;314 IU/dl, were associated with a significantly shorter mean overall survival time (20.08 vs. 31.35 days, p &lt; 0.001), a lower survival rate (30.3% vs. 99.2%, p &lt; 0.001), and a 16.62-fold increased mortality risk.Conclusion: RiCoF is a novel predictor of disease severity in COVID-19, while factor VIII is confirmed as a predictor of severity and mortality in COVID-19 patients and is associated with lower overall survival and increased mortality risk.
Diagnostic Value of Bronchoalveolar Lavage Fluid Metagenomic Next-Generation Sequencing in Pneumocystis jirovecii Pneumonia in Non-HIV Immunosuppressed Patients
Authors: Sun He , Wang Feilong , Zhang Ming , Xu Xiaoyong , Li Miaomiao , Gao Wei , Wu Xiaodong , Han Huize , Wang Qin , Yao Gehong , Lou Zheng , Xia Han , Shi Yi , Li Qiang 
Published: April 2022

IntroductionThis study aims to assess the value of metagenomic next-generation sequencing (mNGS) of bronchoalveolar lavage fluid (BALF) in the diagnosis of Pneumocystis jirovecii pneumonia (PJP) and its mixed infection in non-human immunodeficiency virus (HIV) immunosuppressed patients.MethodsA total of 198 non-HIV immunosuppressed patients with severe pneumonia were enrolled, including 77 PJP patients and 121 patients infected by other pathogens. BALF-mNGS and traditional detection methods were used.ResultsThe positive detection rate of various pathogens of BALF-mNGS was higher than that of the conventional methods, especially for mixed pathogens. The sensitivity and specificity of BALF-mNGS for the diagnosis of PJP were 97.40% and 85.12%, respectively. Compared with traditional methods, the sensitivity of BALF-mNGS was significantly higher than that of blood fungal G (BG)/lactate dehydrogenase (LDH) and BALF-microscopy (p&lt;0.05), and its specificity was significantly higher than that of BG/LDH (p&lt;0.05). In addition, the average detection time of BALF-mNGS (32.76 ± 10.32 h) was also significantly shorter than conventional methods (p&lt;0.01), especially for mixed infections that were common in non-HIV immunosuppressed patients. In patients only detected as positive by BALF-mNGS, the underlying diseases mainly manifested as hematological malignancies with agranulocytosis and within 8 months after hematopoietic stem cell or solid organ transplantation.ConclusionsBALF-mNGS technology is faster, more sensitive, and more comprehensive in detecting P. jirovecii and its mixed infection in immunosuppressed patients.
Application of the Reflectionless Discrete Perfectly Matched Layer for Acoustic Wave Simulation
Authors: Gao Yingjie , Zhu Meng-Hua 
Published: April 2022

The perfectly matched layer (PML) is one of the most popular absorbing boundary conditions for simulating seismic waves. In theory, the PML can absorb incident waves at any incident angle and any frequency in a medium. However, numerical reflections will be generated after the PML has been discretized. Therefore, how to reduce the reflections of discrete PML has been a research topic for more than 2 decades. In this paper, we adopt the reflectionless discrete PML (RD-PML) for seismic wave and implement the RD-PML based on the acoustic wave equation, and then compare its absorbing performance with that of the conventional discrete PML. Our numerical experiments show that the RD-PML has advantages over the conventional discrete PML. In homogeneous model, a thick enough RD-PML can effectively eliminate reflections. In heterogeneous model, a thin-layer RD-PML can obtain better absorbing performance even than the thick-layer conventional discrete PML. The absorbing performance of the RD-PML can be improved by using the periodic boundary without increasing the amount of computation and memory. RD-PML provides a new perspective to understand the discretization of PML, and may play an important role in promoting the development of PML technology.
Recent Advances on Mg–Li–Al Systems for Solid-State Hydrogen Storage: A Review
Authors: Sazelee Noratiqah , Ali Nurul Amirah , Yahya Muhammad Syarifuddin , Mustafa Nurul Shafikah , Halim Yap Firdaus Abdul , Mohamed Saiful Bahri , Ghazali Muhammad Zahruddin , Suwarno Suwarno , Ismail Mohammad 
Published: April 2022

The problem of providing compact and safe storage solutions for hydrogen in solid-state materials is demanding and challenging. The storage solutions for hydrogen required high-capacity storage technologies, which preferably operate at low pressures and have good performances in the kinetics of absorption/desorption. Metal hydrides such as magnesium hydride (MgH2) are promising candidates for such storage solutions, but several drawbacks including high onset desorption temperature (&gt;400°C) and slow sorption kinetics need to be overcome. In this study, we reviewed the recent developments in the hydrogen storage performance development of MgH2 and found that the destabilization concept has been extensively explored. Lithium alanate or LiAlH4 has been used as a destabilizing agent in MgH2–LiAlH4 (Mg–Li–Al) due to its high capacity of hydrogen, which is 10.5 wt.%, and low onset desorption temperature (∼150°C). In this article, a review of the recent advances in the Mg–Li–Al system for the solid-state hydrogen storage material is studied. We discussed the effect of the ratio of MgH2 and LiAlH4, milling time, and additives in the Mg–Li–Al system. After the destabilization concept was introduced, the onset of the desorption temperature and activation energy of MgH2 were reduced, and the sorption properties improved. Further study showed that the intermetallic alloys of Li0.92Mg4.08 and Mg17Al12 that were formed in situ during the dehydrogenation process provide synergetic thermodynamic and kinetic destabilization in the Mg-Li-Al composite system.De/rehydrogenation measurements indicate that the intermetallic alloys of Li0.92Mg4.08 and Mg17Al12 were fully reversibly absorbed and desorbed hydrogen. Next, the remaining challenges and a possible development strategy of the Mg–Li–Al system are analyzed. This review is the first systematic study that focuses on the recent advances in the Mg–Li–Al system for storage solutions for hydrogen in solid-state materials.
Clinical and Genetic Features of Chinese Patients With NIPA1-Related Hereditary Spastic Paraplegia Type 6
Authors: Fu Jun , Ma Mingming , Li Gang , Zhang Jiewen 
Published: April 2022

Background: Mutations in the NIPA1 gene cause hereditary spastic paraplegia (HSP) type 6 (SPG6), which is a rare type of HSP with a frequency of less than 1% in Europe. To date, less than 30 SPG6 families and limited NIPA1 mutations have been reported in different ethnic regions. The clinical features are variable.Methods: We screened for NIPA1 mutations by whole exome sequencing or next generation sequencing in 35 unrelated Chinese families with HSP. The clinical manifestations were evaluated.Results: Two variants of NIPA1 were identified in three index patients (3/35, 8.6%), two of whom carried a previously reported common variant c.316G &gt; A (p.G106R), and the third patient harbored a novel likely pathogenic variant c.126C &gt; G (p.N42K). Both variants were de novo in the three index patients. The phenotype was pure HSP in two patients and complicated HSP with epilepsy in the third one.Conclusion:NIPA1-related HSP is more common in China than it in Europe. Both pure and complicated form of HSP can be found. The variant c.316G &gt; A is a hotspot mutation, and the novel variant c.126C &gt; G expands the mutational spectrum. The phenomenon of de novo mutations in NIPA1 emphasizes the need to consider autosomal dominant HSP-related genes in sporadic patients.
Predictability of 6 Intraocular Lens Power Calculation Formulas in People With Very High Myopia
Authors: Chu Yi-Ching , Huang Tzu-Lun , Chang Pei-Yao , Ho Wei-Ting , Hsu Yung-Ray , Chang Shu-Wen , Wang Jia-Kang 
Published: April 2022

PurposeTo investigate the accuracy of 6 intraocular lens (IOL) power calculation formulas in predicting refractive outcomes in extremely long eyes.SettingDepartment of Ophthalmology, Far Eastern Memorial Hospital, Taiwan.DesignRetrospective comparative study.MethodsIn this retrospective single-center study, we reviewed 70 eyes of 70 patients with axial length (AL) ≥ 28 mm who had received an uneventful 2.2 mm corneal wound phacoemulsification and in-the-bag IOL placement. The actual postoperative refractive results were compared to the predicted refraction calculated with 6 formulas (Haigis, Hoffer Q, Holladay 1, SRK/T, T2, Barrett Universal II formulas) using IOLMaster 500 as optical biometry in the User Group for Laser Interference Biometry (ULIB) constants.ResultsOverall, the Haigis and Barrett formulas achieved the lowest level of mean prediction error (PE) and median absolute error (MedAE). Hoffer Q, Holladay 1, SRK/T, and T2 had hyperopic prediction errors (p &lt; 0.05). The Hoffer Q and Holladay 1 had significantly more MedAE between the 6 formulas. After the mean PE was zeroed out, the MedAE had no significant difference between each group. The absolute error tends to be larger in patients with longer AL. The absolute errors were 30.0–37.1% and 60.0–64.3% within 1.0 D of all patients compared to predicted refraction calculated using various formulas.ConclusionThe Haigis and Barrett Universal II formulas had a better success rate in predicting IOL power in high myopic eyes with AL longer than 28 mm using the ULIB constant in this study. The postoperative refractive results were inferior to the benchmark standards, which indicated that the precision of IOL power calculation in patients with high myopia still required improvement.