bluuebunny/crossref_metadata_2025_split huggingface dataset:
Network Association of Biochemical and Inflammatory Abnormalities With Psychiatric Symptoms in First-Episode Schizophrenia Patients
Authors: Yan Junwei , Chen Yuanyuan , Ju Peijun , Gao Jianliang , Zhang Loufeng , Li Jingwei , Wang Keming , Zhang Jie , Li Chao , Xia Qingrong , Zhu Cuizhen , Zhang Xulai 
Published: February 2022

BackgroundCardiovascular disease (CVD) risk factors such as dyslipidemia and systemic aberrant inflammatory processes may occur in patients with psychotic disorders, which may cause increased mortality. The interplay between immune and metabolic markers and its contribution to the clinical symptoms of schizophrenia (SCZ) remain unclear. This study aimed to examine the association of a series of inflammatory factors, plasma biochemical indicators, and SCZ clinical symptomatology with the severity of SCZ symptoms.MethodsA total of 115 participants, including 79 first-episode drug-naïve patients with SCZ and 36 healthy controls, were enrolled in this study. Semi-structured interviews were used to collect sociodemographic data, family history of SCZ, and medical and psychiatric history. The Brief Psychiatric Rating Scale (BPRS) and the Positive and Negative Syndrome Scale (PANSS) were administered by a clinical psychiatrist to evaluate the symptom severity of patients with SCZ. Plasma inflammatory cytokines were measured by a fully automated electrochemiluminescent immunoassay (Meso Scale Discovery).ResultsBlood routine, biochemical, and inflammation cytokine test results showed that the levels of white blood cell count, neutrophil count, natrium, CRP, IL-8, IL-6, IL-13, and IL-16 significantly increased in the case group than in the healthy controls (p &lt; 0.05), whereas levels of red blood cell count, hemoglobin concentration, mean corpuscular hemoglobin concentration, total protein, albumin, total bile acid, high-density lipoprotein (HDL), apolipoprotein A1, blood urea nitrogen, kalium and IL-15 were lower than in the healthy controls (p &lt; 0.05). Correlation network analysis results shown that the natrium, HDL and red blood cell count were the top 3 factors closely to with BPRS and PANSS related clinical symptoms among of correlation network (degree = 4). ROC curve analysis explored the IL-16, IL-8, IL-13, IL-15, natrium, and HDL had highly sensitivity and specificity to the predictive validity and effectiveness for SCZ symptoms.ConclusionOur study revealed a complex interactive network correlation among the cardiovascular risk factors, biological immunity profiles, and psychotic symptoms in first-episode patients. Abnormal inflammatory factors and CVD risk factors had high sensitivity and specificity for predicting SCZ symptoms. Generally, our study provided novel information on the immune-related mechanisms involved in early CVD risk in patients with psychotic disorders.
Feasibility and Acceptability of Game-Based Cortical Priming and Functional Lower Limb Training in a Remotely Supervised Home Setting for Chronic Stroke: A Case Series
Authors: Lim Hyosok , Marjanovic Nicholas , Luciano Cristian , Madhavan Sangeetha 
Published: February 2022

BackgroundMovement-based priming has been increasingly investigated to accelerate the effects of subsequent motor training. The feasibility and acceptability of this approach at home has not been studied. We developed a game-based priming system (DIG-I-PRIMETM) that engages the user in repeated ankle movements using serious games. We aimed to determine the feasibility, acceptability, and preliminary motor benefits of an 8-week remotely supervised telerehabilitation program utilizing game-based movement priming combined with functional lower limb motor training in chronic stroke survivors.MethodsThree individuals with stroke participated in a telerehabilitation program consisting of 20-min movement-based priming using the DIG-I-PRIMETM system followed by 30-min of lower limb motor training focusing on strength and balance. We evaluated feasibility using reported adverse events and compliance, and acceptability by assessing participant perception of the game-based training. Motor gains were assessed using the 10-m walk test and Functional Gait Assessment.ResultsAll participants completed 24 remotely supervised training sessions without any adverse events. Participants reported high acceptability of the DIG-I-PRIMETM system, reflected by high scores on satisfaction, enjoyment, user-friendliness, and challenge aspects of the system. Participants reported overall satisfaction with our program. Post-training changes in the 10-m walk test (0.10–0.31 m/s) and Functional Gait Assessment (4–7 points) exceeded the minimal clinically important difference.ConclusionOur results indicate that a remotely supervised game-based priming and functional lower limb exercise program is feasible and acceptable for stroke survivors to perform at home. Also, improved walking provides preliminary evidence of game-based priming to be beneficial as a telerehabilitation strategy for stroke motor recovery.
Symmetrical Dimethylarginine as a Diagnostic Parameter in Hermann's Tortoises (Testudo hermanni)
Authors: Lehmann Verena , Altherr Barblin , Pantchev Nikola , Öfner Sabine , Zablotski Yury , Murphy Rachel , Coyne Michael , Kölle Petra 
Published: February 2022

BackgroundDespite improvements in habitational conditions, kidney disease is relatively common in tortoises.ObjectivesPurpose of this study was the establishment of Symmetrical dimethylarginine (SDMA) reference values for clinically healthy Hermann's Tortoises.AnimalsClinically healthy Hermann's Tortoises (n = 131) were included in the period from October 2017 to September 2019.MethodsCreatinine and other biomarkers were tested at IDEXX Laboratories, Germany using residual blood samples from Hermann's tortoises. SDMA was measured with the IDEXX test and verified by liquid chromatography-mass spectrometry at IDEXX Laboratories, USA.ResultsSDMA values ranged from 1 to 21 μg/dl (n = 131) for the IDEXX SDMA Test and SDMA values ranged from 1 to 17 μg/dl (n = 82) for LC-MS. For the comparison of the two measuring systems, the following results were obtained R2 = 0.75 (p &lt; 0.001).Conclusion and Clinical ImportanceSDMA can be measured in Hermann's Tortoises and the reference values range in clinically healthy animals is comparable to that of dogs and cats.
Study of crushing of grains of limestone under the effect of cyclic loading with the fractal dimension
Authors: Bouzeboudja Aldjia , Melbouci Bachir , Bouzeboudja Ouardia 
Published: February 2022

The grains can be of very diverse nature (size, shape, mineralogy, etc), indeed even if each grain is a fairly simple object, the set of grains is a very complex system in which the geometrical and physical properties of the grains, their forces and their orientations play a crucial role in their mechanical behavior. The measurement of their shape in soil mechanics has historically required the use of standards and diagrams to which the different grains can be compared. However, these methods are approaches and remain insufficient and incomplete for the actual measurement of their form and the understanding of their behavior remains a task far from being completed.
This work is in this context and proposes to analyze the shape and size of the grains with the fractal theory using the Box Counting method. It also makes it possible to study their influence on the crushing of the grains of the calcareous material under the effect of the cyclic loading-unloading during the oedometer test. The obtained results show that the variation of the fractal dimension, corresponding to the crushing effect of the grains, is strongly influenced by their shape, their size, their particle size distribution and the variation in the number of loading-unloading cycles.
Comparative design procedures of stone columns for liquefaction stabilization
Authors: Messafer Tahar , Hassak Mohamed Oussama , Abzar Adem 
Published: February 2022

Soil liquefaction is one of the most important and complex phenomena of soil dynamics. It is a loss of résistance of loose granular soils under a seismic shock.
The aim of this work is to study the improvement made on a liquefiable soil using a stone column solution by several methods namely observational, static and dynamic solutions. The site used for this application is located in a terminal port container in Algiers. The analysis was carried out using the test results of standard penetration and cone penetrometer tests completed during a site investigation.
A comparative study between the methods was carried out to determine the most suitable method. The results of the 3 methods showed that the sizing by taking into account the earthquake, the mesh of stone columns is denser. It was deduced that it is important to analyze by the dynamic method in seismic zones and by static or observational techniques in areas of no or low risk of liquefaction. Recommendation for further research was put forward to develop new tools in order to improve current design methods.
PENGARUH LEVERAGE, EARNING POWER, DAN KEPEMILIKAN MANAJERIAL TERHADAP MANAJEMEN LABA
Authors: Loen, SE., M.Si. Mishelei 
Published: February 2022

<p><em>The purpose of the reasearch to find out and analyze the effect of Leverage, Earning Power, and Managerial Ownership of Earnings Management, Study on Companies Conducting Right Issues on the Indonesia St</em><em>ock Exchange for the period 2016-2020</em><em>.</em><em> T</em><em>he analytical method used in this study </em><em>namely by </em><em>using descriptive statistical methods and multiple regression then using classical assumption and hypothesis testing using T test, F test and R² test, sampling using purposive sampling method with a population of 55 from the population obtained 18 samples. The results showed that partially or according to the results of the T test, that Leverage, Earning Power, and Managerial Ownership have a significant effect on Study Management in Companies Conducting Right Issues on the Indon</em><em>esia Stock Exchange for the 2016-2020</em><em> period.</em></p><div id="essential_id_for_layout" style="position: fixed; width: 100%; height: 100%; top: 0px; left: 0px; bottom: 0px; right: 0px; display: none; background-color: rgba(0, 0, 0, 0.3); z-index: 9999999; cursor: pointer;"> </div>
Sistem Prediksi Persediaan Stok Darah Dengan Metode Least Square Pada Unit Transfusi Darah Studi Kasus PMI Kota Cirebon
Authors: Hatta Muhammad , Fauziah Fitri Alfi 
Published: February 2022

Unit Transfusi darah (UTD) sebagai penyedia pasokan darah diperlukan untuk memenuhi permintaan darah, namun dalam kenyataannya, stok darah tidak selalu memenuhi permintaan darah. Jumlah stok golongan darah di UTD tergantung pada donor darah yang secara sukarela mendonorkan darah. Sel darah merah hanya memiliki rentang hidup 35 hari sejak mereka disumbangkan, jika mereka telah melewati waktu itu darah tidak dapat digunakan untuk transfusi. Faktor atau parameter yang mempengaruhi jumlah produk darah menuntut, yaitu lingkungan, wabah penyakit dan perbedaan daya tahan tubuh masing-masing golongan darah. Selain itu, jenis-jenis produk darah juga memiliki sejumlah permintaan berbeda tergantung pada tingkat kebutuhan darah untuk kesehatan. Sehingga perlu sebuah sistem prediksi persediaan stok obat untuk periode berikutnya, dalam prediksi menggunakan adalah metode Least Square. Hasil dari penelitian ini adalah sistem informasi prediksi kebutuhan stok daraah untuk periode berikunya sehingga memudahkan petugas dalam mengelola data-data serta data laporan permintaan darah dan stok darah per periode.
Penerapan Metode Simple Additive Weighting Untuk Menentukan Penggunaan Dana Bantuan Operasional Sekolah
Authors: Irawan Puja , Sokibi Petrus , Susanto Ivan 
Published: February 2022

Dana Bantuan Operasional Sekolah (BOS) merupakan salah satu bentuk upaya pemerintah untuk mendukung pendidikan di Indoensia. Dana BOS dapat diterima oleh sekolah dengan mengikuti persyaratan yang berlaku. Penentuan penggunaan dana BOS umunya dilakukan dengan hasil suara terbanyak yang didapatkan ketika rapat penggunaan dana BOS. Hal tersebut dianggap kurang efektif karena tidak jelas keprioritasaanya, sehingga untuk mendapatkan hasil keputusan yang lebih efektif solusinya adalah dengan menggunakaan sebuah sistem untuk menunjang keputusan.Sistem Pendukung Keputusan untuk menentukan penggunaan dana BOS dilakukan dengan menggunakan metode Simple Additive Weighting (SAW). Sistem ini berbasis web yang dibuat dengan memanfaatkan seperangkat komputer yaitu laptop dan menggunakan bahasa pemrograman PHP (Hypertext Preprocessor) serta menggunakan database MySQL. Sistem ini dapat digunakan untuk melakukan pengajuan dan menghitung data pengajuan. Dari hasil perhitungan tersebut Kepala Sekolah dapat memilih pengajuan yang akan disetujui dengan mempertimbangkan hasil perhitungan metode SAW. Sistem ini menghasilkan informasi berupa laporan penggunaan dana BOS yang dapat dilihat oleh guru dan orang tua siswa. Kelebihan dari sistem ini adalah informasi penggunaan dana BOS disertai dengan tingkat keprioritasannya karena sistem ini menerapkan metode SAW untuk menunjang keputusan penentuan penggunaan dana BOS, namun laporan yang dihasilkan hanya sebagai informasi penggunaan dana BOS bukan untuk laporan kepada kementrian pendidikan dan kebudayaan.

Kata Kunci: Sistem Pendukung Keputusan, Bantuan Operasional Sekolah, Web.
Elementos constituintes da identidade docente de duas professoras experientes dos anos iniciais do ensino fundamental
Authors: Francine Ferreira da Silva Jéssica , Gestoso de Souza Ana Paula , Massako Murakami Tiba Aline 
Published: February 2022

Resumo: A aprendizagem da docência percorre a trajetória pessoal, os processos formativos e profissionais dos professores e sofre influência de diferentes aspectos, sendo estes responsáveis pela construção da identidade profissional docente. Por essas reflexões, este estudo procurou responder: quais elementos caracterizam a constituição da identidade docente de duas professoras experientes dos anos iniciais do Ensino Fundamental? Esses elementos podem ter influenciado na escolha e interesse de participarem de um programa de mentoria? De que maneira? Buscou-se identificar elementos e características desse processo, por meio da análise de memoriais de formação, e observar de que maneiras essa constituição influenciou na escolha e no interesse de atuarem em um programa de mentoria. Sob um viés qualitativo, foram analisados o percurso da infância e escolarização, a formação inicial, o início da docência e a trajetória de atuação profissional, com enfoque no início da carreira. Os resultados apontam que a família, o exemplo/modelo de professores, os colegas de trabalho, as experiências de formação continuada, o comprometimento político, o envolvimento em processos reflexivos e o ser resiliente, influenciaram fortemente na construção da identidade docente das professoras. Nesse sentido, observou-se que alguns desses elementos, constituintes de suas identidades docentes, como o apoio recebido por seus pares (iniciantes e experientes) no início da carreira, a busca constante por formação continuada e o comprometimento e engajamento político parecem ter influenciado na escolha dessas professoras de atuarem como mentoras de professores iniciantes.
Palavras-chave: Desenvolvimento profissional docente. Formação contínua. Memoriais de formação.
Overseas Job Opportunity among Fresh Graduate of Healthcare Workers: A SWOT Analysis
Authors: Tukayo Isak Jurun Hans , Hardy Syaifoel , Yuliyanik  , Fakhruddin Akhir , Afzal Ridha , Al-Jaidah Mahmood Abdulrahman Mahmood 
Published: February 2022

The chronic reasons why Indonesian healthcare workers are reluctant to work abroad are allegedly due to inadequate English language proficiency and family encouragement. The demand, opportunities, and benefits of working abroad are increasing from year to year. Unfortunately, the opportunity is poorly anticipated. The objective is to explore the current demand, challenges and offer strategies to elevate the interest of Indonesian healthcare workers to work abroad. This study used a quantitative method with the Strength, Weaknesses, Opportunity, Threats (SWOT) Analysis supported by the PICOT (Participants, Intervention, Comparison, Outcome, Time) model to differentiate the demand, interest, and challenges of the professions. A mixed questionnaire was distributed among the population of 148 students from 3 majors: nursing (n-84), midwifery (n=23), and environmental health (n=61) collected randomly as the purposive sampling. The population were graduates holders (n=87) and diploma holders (n=61), i.e. nursing (n=84), midwifery (n=23), and environmental health (n=61). Results showed that nursing professional was more dominant and demanded abroad. The participants were interested if the training was provided (n=141 or 84%). The weakness was lack of language proficiency (n=93), and lack of preparation (n=76). The challenges mainly were due to inadequate preparation (languages, family support, and financial). The study recommended a structured preparation program with an integrated approach during college time.
Jatuhnya Nilai Rupiah dan Krisis Ekonomi Menurut Pemikiran Ibnu Taimmiyah
Authors: Hafizi Royyan , Zubaedah Putri Amalia 
Published: February 2022

Artikel ini menjelaskan mengenai pemikiran ibnu taimmiyah terhadap jatuhnya nilai mata uang dan krisis ekonomi dan juga jatuhnya nilai rupiah serta krisis ekonomi di Indonesia. Metode penelitian yang digunakan adalah melalui pendekatan kualitatif dengan mencari beberapa referensi dan literature review yang mendukung materi penelitian. Dalam penelitian ini penulis menemukan masalah mengenai sebab jatuhnya mata uang rupiah serta krisis ekonomi yang terjadi di Negara Indonesia. Penelitian ini bertujuan agar pembaca dapat memahami sebab jatuhnya mata uang yang pernah terjadi pada masa ibnu Taimiyah dan mengkorelasikan dengan jatuhnya nilai rupiah saat ini di Indonesia, selain itu penelitian ini bertujuan agar pembaca dapat memahami mengenai krisis ekonomi menurut pemikiran ibnu Taimmiyah, dalam artikel ini juga akan di paparkan solusi yang bisa diterapkan agar krisis moneter dapat diatasi secara efektif dan efisien berdasarkan pandangan ibnu Taimmiyyah. Hasil penelitian ini yaitu: Menurut Ibnu Taimiyyah, jatuhnya nilai mata uang disebabkan karena pencetakan uang yang terlalu banyak. Ibnu Taimiyyah mengatakan bahwa otoritas pemerintah harus mencetak mata uang koin (emas maupun perak) sesuai dengan nilai transaksi yang adil dari penduduk,tanpa keterlibatan kezaliman didalamnya. Menurut Ibnu Taimiyyah Inflasi tersebut terjadi Karena adanya peredaran mata uang yang tidak seimbang, yaitu dengan pencetakan fulus yang nilai nominalnya tidak seimbang dengan kandungan logam, sehingga apabila dibelanjakan untuk emas dan perak, maupun barang-barang berharga lainnya, nilai mata uang tersebut menjadi menurun, dan akhirnya timbul inflasi. Kemudian Ibnu Taimiyyah memberikan solusi pemikirannya terhadap krisis moneter yaitu dengan memperhatikan tiga hal yaitu : mekanisme pasar yang stabil, regulasi harga yang harus ditetapkan pemerintah secara adil, dan kebijakan moneter oleh pemerintah.
PENERAPAN MODEL PEMBELAJARAN BERBASIS MASALAH UNTUK MENINGKATKAN HASIL BELAJAR SISWA KELAS XI IPA PADA MATERI ASAM BASA
Authors: Nur Rizki Amalia , Haeruddin Haeruddin , Tewa Yuniati 
Published: February 2022

Telah dilakukan penelitian dengan judul “Penerapan Model Pembelajaran Berbasis Masalah untuk Meningkatkan Hasil Belajar Siswa Kelas XI IPA 1 SMAN 10 Kendari pada Materi Asam Basa”. Penelitian ini bertujuan : (1) untuk mengetahui hasil belajar siswa kelas XI IPA 1 SMAN 10 Kendari yang diajar dengan model pembelajaran berbasis masalah pada materi asam basa; (2) untuk mengetahui aktivitas belajar siswa kelas XI IPA 1 SMAN 10 Kendari dan mengajar guru dengan menggunakan model pembelajaran berbasis masalah di SMAN 10 Kendari; (3) untuk mengetahui respon siswa kelas XI IPA 1 SMAN 10 Kendari terhadap model pembelajaran berbasis masalah pada materi asam basa; (4) untuk mengetahui pengaruh model pembelajaran berbasis masalah pada siswa siswa kelas XI IPA 1 SMAN 10 Kendari pada materi asam basa. Jenis penelitian ini yaitu penelitian eksperimen dengan desain penelitian yaitu one group pretest posttest design. Sampel penelitian ini yaitu siswa kelas kelas XI IPA 1 SMAN 10 Kendari yang berjumlah 20 siswa. Hasil penelitian ini menunjukkan bahwa rata-rata hasil belajar siswa mengalami peningkatan setelah diajar dengan model pembelajaran berbasis masalah yaitu 73,50. N-gain yang diperoleh sebesar 0,65 dengan kategori keefektifan tinggi, sehingga model pembelajaran berbasis masalah dapat dikatakan efektif diajarkan pada siswa kelas XI IPA 1 pada materi asam basa. Terdapat pengaruh yang signifikan model pembelajaran berbasis masalah terhadap hasil belajar siswa SMAN 10 Kendari pada materi asam basa
FITOKIMIA DAN UJI AKTIVITAS ANTIOKSIDAN EKSTRAK ETANOL DAUN SONI (Dillenia serrata Thunb) DENGAN METODE DPPH
Authors: Purnawati Alna , Nurlansi Nurlansi , Nasrudin Nasrudin 
Published: February 2022

Telah dilakukan penelitian Fitokimia dan Uji Aktivitas Antioksidan Ekstrak Etanol Daun Soni (Dillenia serrata Thunb) dengan Metode DPPH. Penelitian ini bertujuan untuk mengetahui senyawa metabolit sekunder dan aktivitas antioksidan dari ekstrak Ekstrak Etanol Daun Soni (Dillenia serrata Thunb).Senyawa metabolit sekunder yang terkandung dalam ekstrak etanol daun Daun Soni ditentukan dengan metode fitokimia, sedangkan aktivitas antioksidannya dengan metode DPPH. Daun soni yang digunakan adalah daun soni kering yang telah dihaluskan. Sebanyak 500g daun soni dimaserasi selama 3x24 jam dengan pelarut etanol 96% yang sudah didestilasi. Ekstrak kemudian dikumpulkan dan dipekatkan sehingga diperoleh ekstrak kental sebanyak 145 g. Ekstrak di uji fitokimia dan antioksidan. Hasil uji fitokimia menunjukkan bahwa ekstrak etanol daun soni mengandung alkaloid, flavonoid, steroid, saponin, polifenol, dan tanin.Ekstrak etanol daunsonimemiliki aktivitas antioksidan kuat dengan nilai IC50 sebesar 15.3048 ± 0.2365 ppm.
Penerapan Model Pembelajaran Problem Solving untuk Meningkatkan Hasil Belajar SISWA KELAS X MIA 1 pada Materi Pokok Larutan Elektrolit dan Non Elektrolit SMA Negeri 1 Wonggeduku
Authors: Sari Winda , Saefuddin Saefuddin , Dahlan Dahlan 
Published: February 2022

Penelitian ini bertujuan untuk mengetahui : (1) Peningkatan aktivitas guru dan siswa yang diajar menggunakan model pembelajaran problem solving (2) hasil belajar kimia siswa kelas X MIA 1 setelah diajar dengan menggunakan model pembelajaran problem solving pada materi elektrolit dan non elektrolit, (3) keefektifan penerapan model pembelajaran problem solving terhadap hasil belajar siswa kelas X IPA 2 pada materi larutan elektrolit dan non elektrolit, dan (4) respon siswa terhadap penerapan model pembelajaran problem solving pada materi elektrolit dan non elektrolit. Penelitian ini menggunakan metode pre-eksperiment, desain penelitian yang digunakan adalah One-group Pretest Posttest Design, yaitu penelitian dilaksanakan pada satu kelompok saja tanpa ada kelompok pembanding. Teknik pengumpulan data dilakukan dengan pemberian instrumen penelitian berupa soal pilihan ganda berjumlah 20 butir soal, lembar bservasi dan angket. Hasil penelitian ini menunjukkan bahwa: (1) Persentase aktivitas siswa yang diajar menggunakan model pembelajaran problem solving meningkat dengan persentase pada pertemuan 1 sebesar 86 % menjadi 89,4 % pada pertemuan kedua, dan untuk aktivitas guru meningkat dari 85 % pada pertemuan pertama menjadi 85,5 % pada pertemuan kedua (2) Hasil belajar kimia siswa kelas X MIA 1SMAN 1 WONGGEDUKU yang diajar menggunakan model problem solving pada pokok bahasan larutan elektrolit dan nonelektrolit siswa berada pada kategori sedang dengan nilai rata-rata 78,1. (3) Penerapan model problem solving dalam proses pembelajaran cukup efektif dengan nilai rata-rata N-gain sebesar 0,69 (sedang). (4) Siswa memberikan respon yang sangat positif terhadap penggunaan model pembelajaran problem solving dengan skor respon sebesar 76% atau berada pada kategori sangat baik.