bluuebunny/crossref_metadata_2025_split huggingface dataset:
Differences in risk factors for incident and recurrent preterm birth: a population-based linkage of 3.5 million births from the CIDACS birth cohort
Authors: Rocha Aline S. , de Cássia Ribeiro-Silva Rita , Fiaccone Rosemeire L. , Paixao Enny S. , Falcão Ila R. , Alves Flavia Jôse O. , Silva Natanael J. , Ortelan Naiá , Rodrigues Laura C. , Ichihara Maria Yury , de Almeida Marcia F. , Barreto Mauricio L. 
Published: April 2022

Abstract
Background
Preterm birth (PTB) is a syndrome resulting from a complex list of underlying causes and factors, and whether these risk factors differ in the context of prior PTB history is less understood. The aim of this study was to explore whether PTB risk factors in a second pregnancy were different in women with versus without previous PTB.

Methods
We conducted a population-based cohort study using data from the birth cohort of the Center for Data and Knowledge Integration for Health (CIDACS) for the period 2001 to 2015. We used longitudinal transition models with multivariate logistic regression to investigate whether risk factors varied between incident and recurrent PTB.

Results
A total of 3,528,050 live births from 1,764,025 multiparous women were analyzed. We identified different risk factors (Pdifference <0.05) between incident and recurrent PTB. The following were associated with an increased chance for PTB incidence, but not recurrent: household overcrowding (OR 1.09), maternal race/ethnicity [(Black/mixed—OR 1.04) and (indigenous—OR 1.34)], young maternal age (14 to 19 years—OR 1.16), and cesarean delivery (OR 1.09). The following were associated with both incident and recurrent PTB, respectively: single marital status (OR 0.85 vs 0.90), reduced number of prenatal visits [(no visit—OR 2.56 vs OR 2.16) and (1 to 3 visits—OR 2.44 vs OR 2.24)], short interbirth interval [(12 to 23 months—OR 1.04 vs OR 1.22) and (<12 months, OR 1.89, 95 vs OR 2.58)], and advanced maternal age (35–49 years—OR 1.42 vs OR 1.45). For most risk factors, the point estimates were higher for incident PTB than recurrent PTB.

Conclusions
The risk factors for PTB in the second pregnancy differed according to women’s first pregnancy PTB status. The findings give the basis for the development of specific prevention strategies for PTB in a subsequent pregnancy.
Connective tissue growth factor mediates bone morphogenetic protein 2-induced increase in hyaluronan production in luteinized human granulosa cells
Authors: Chang Hsun-Ming , Bai Long , Zhu Yi-Min , Leung Peter C. K. 
Published: April 2022

Abstract
Background
Hyaluronan is the main component of the cumulus-oocyte complex (COC) matrix, and it maintains the basic structure of the COC during ovulation. As a member of the transforming growth factor β (TGF-β) superfamily, bone morphogenetic protein 2 (BMP2) has been identified as a critical regulator of mammalian folliculogenesis and ovulation. However, whether BMP2 can regulate the production of hyaluronan in human granulosa cells has never been elucidated.

Methods
In the present study, we investigated the effect of BMP2 on the production of hyaluronan and the underlying molecular mechanism using both immortalized (SVOG) and primary human granulosa-lutein (hGL) cells. The expression of three hyaluronan synthases (including HAS1, HAS2 and HAS3) were examined following cell incubation with BMP2 at different concentrations. The concentrations of the hyaluronan cell culture medium were determined by enzyme-linked immunosorbent assay (ELISA). The TGF-β type I receptor inhibitors (dorsomorphin and DMH-1) and small interfering RNAs targeting ALK2, ALK3, ALK6 and SMAD4 were used to investigate the involvement of TGF-β type I receptor and SMAD-dependent pathway.

Results
Our results showed that BMP2 treatment significantly increased the production of hyaluronan by upregulating the expression of hyaluronan synthase 2 (HAS2). In addition, BMP2 upregulates the expression of connective tissue growth factor (CTGF), which subsequently mediates the BMP2-induced increases in HAS2 expression and hyaluronan production because overexpression of CTGF enhances, whereas knockdown of CTGF reverses, these effects. Notably, using kinase inhibitor- and siRNA-mediated knockdown approaches, we demonstrated that the inductive effect of BMP2 on the upregulation of CTGF is mediated by the ALK2/ALK3-mediated SMAD-dependent signaling pathway.

Conclusions
Our findings provide new insight into the molecular mechanism by which BMP2 promotes the production of hyaluronan in human granulosa cells.
Potential application of hydrogel to the diagnosis and treatment of multiple sclerosis
Authors: Liu Haochuan , Chen Bing , Zhu Qingsan 
Published: April 2022

Abstract
Multiple sclerosis (MS) is a chronic demyelinating disease of the central nervous system. This disorder may cause progressive and permanent impairment, placing significant physical and psychological strain on sufferers. Each progress in MS therapy marks a significant advancement in neurological research. Hydrogels can serve as a scaffold with high water content, high expansibility, and biocompatibility to improve MS cell proliferation in vitro and therapeutic drug delivery to cells in vivo. Hydrogels may also be utilized as biosensors to detect MS-related proteins. Recent research has employed hydrogels as an adjuvant imaging agent in immunohistochemistry assays. Following an overview of the development and use of hydrogels in MS diagnostic and therapy, this review discussed hydrogel’s advantages and future opportunities in the diagnosis and treatment of MS.

Graphical abstract
A multicenter non-inferior randomized controlled study comparing the efficacy of laparoscopic versus abdominal radical hysterectomy for cervical cancer (stages IB1, IB2, and IIA1): study protocol of the LAUNCH 2 trial
Authors: Wu Xin , Qiu Ling , Lou Weihua , Wang Xipeng , Zhu Tao , Zhang Yuyang , Hu Weiguo , Xue Xiaohong , Zhu Zhiling , Xiang Libing , Li Jiarui , Fang Xuhong , Gao Shujun , Feng Hua , Diao Wenjing , Zhang Hongwei , Du Ming , Bai Yongrui , Hou Yanli , Yan Weili , Feng Hao , Yu Hailing , Zhu Shurong , Du Yan , Jiang Hua 
Published: April 2022

Abstract
Background
A retrospective study and a randomized controlled trial published in late 2018 have shown that laparoscopic radical hysterectomy (RH) was associated with worse survival than abdominal RH among patients with early-stage cervical cancer. Radical hysterectomy in cervical cancer has been a classic landmark surgery in gynecology; therefore, this conclusion is pivotal. The current trial is designed to reconfirm whether there is a difference between laparoscopic RH and abdominal RH in cervical cancer (stages IB1, IB2, and IIA1) patient survival under stringent operation standards and consistent surgical oncologic principles.

Methods/design
This is an investigator-initiated, Prospective, Randomized, Open, Blinded End-point (PROBE)-controlled non-inferiority trial. A total of 780 patients with stage IB1, IB2, and IIA1 cervical cancer will be enrolled over a period of 3 years. Patients are randomized (1:1) to either the laparoscopic RH or the abdominal RH group. Patients will then be followed up for at least 5 years. The primary endpoint will be 5-year progression-free survival, and secondary endpoints include 5-year overall survival, recurrence, and quality of life measurements.

Discussion
The debate on laparoscopic versus abdominal RH is still ongoing, and high-quality evidences are needed to guide clinical practice. The study results will provide more convincing evidence-based information for early-stage cervical cancer patients and their gynecologic cancer surgeons in their choice of surgical method.

Trial registration
ClinicalTrials.govNCT04929769. Registered on 18 June 2021
Educational intervention for the prevention of occupational neck pain: protocol of randomized trial
Authors: Moradi Zohreh , Tavafian Sedigheh Sadat , Kazemi Seyedeh Somayeh 
Published: April 2022

Abstract
Background
Neck pain is one of the most common work-related musculoskeletal disorders (WMSDs). It has important social and economic consequences such as reduced productivity due to absenteeism, leave, and early retirement and financial losses due to medical expenses for the workforce especially teachers. This study aims to evaluate whether a model-based social media intervention could change the high-risk behaviors that cause work-related neck pain among teachers.

Methods
This is a randomized controlled trial that will be done in three steps. The first stage is a qualitative study to obtain the items and areas of the researcher-made questionnaire based on the health belief model (HBM), the second stage is the psychometric evaluation of the questionnaire, and the third stage is designing and implementation of model-based educational intervention in social media context. The study population is teachers who working in junior high school in the 19th district of education minister in Tehran, Iran, which are randomly divided into two groups of intervention and control. The intervention group receives training packages on social media, and the control group does not receive any training. The educational intervention tries to improve the knowledge, attitude, skills, and self-efficacy in adopting neck pain prevention behaviors among teachers. The study will also assess whether the intervention can promote preventive neck pain behavior among teachers.

Discussion
Work-related neck pain can have a negative impact on teachers’ health. This study is an attempt to investigate the impact of developed interventions in promoting preventive behavior regarding work-related neck pain through social media context.

Trial registration
Iranian registry of Clinical Trial (IRCT) IRCT20210301050542N1. Registered on 16 March 2021
Ethics code: IR.MODARES.REC.1399.163
Evaluation of right ventricular systolic and diastolic dysfunctions in patients with type 2 diabetes mellitus with poor glycemic control by layer specific global longitudinal strain and strain rate
Authors: Huang Jun , Li Li , Fan Li , Chen Dong-liang 
Published: April 2022

Abstract
Background
In order to evaluate right ventricular (RV) systolic and diastolic dysfunctions in patients with type 2 diabetes mellitus (T2DM) with poor glycemic control by layer specific global longitudinal strain (GLS) and strain rate (GLSr).

Methods
68 T2DM patients and 66 normal controls were enrolled for the present study. RV layer specific GLS (GLSEpi, GLSMid and GLSEndo represent the epimyocardial, middle layer and endomyocardial strains, respectively) and GLSr (GLSr-S, GLSr-E and GLSr-A represent the systole, early-diastole and late-diastole strain rate) were calculated by averaging each of the three regional peak systolic strains and strain rates along the entire RV free-wall (RVFW), entire RV free-wall and septal wall (RVFSW) on RV-focused view.

Results
The absolute values of RV layer specific GLS (GLSEpi, GLSMid and GLSEndo) in RVFW in T2DM patients were significantly lower than normal controls (P < 0.01), while GLSr-A was significantly larger than normal controls (P < 0.001). The absolute values of RV layer specific GLS (GLSEpi and GLSMid) in RVFSW in T2DM patients were significantly lower than normal controls (P < 0.05), while GLSr-A was significantly larger than normal controls (P < 0.001). HbA1c were poor negatived correlated with GLSEpi in RVFW and RVFSW in T2DM patients (P < 0.05). ROC analysis showed that RV layer specific GLS and GLSr-A had a high diagnostic efficacy in T2DM patients, and GLSr-A in RVFSW have the best diagnostic value in RV diastolic function in T2DM patients (AUC: 0.773).

Conclusion
From the research, we found that layer specific GLS and GLSr could detect the RV myocardial dysfunctions and confirmed that the impaired RV systolic and diastole functions in T2DM patients with poor glycemic control. GLSr-A in RVFSW had the best diagnostic value in evaluating RV diastolic function in T2DM patients.
Mesial temporal tau in amyloid-β-negative cognitively normal older persons
Authors: Krishnadas Natasha , Doré Vincent , Groot Colin , Lamb Fiona , Bourgeat Pierrick , Burnham Samantha C. , Huang Kun , Goh Anita M. Y. , Masters Colin L. , Villemagne Victor L. , Rowe Christopher C. ,   for the AIBL research group
Published: April 2022

Abstract
Background
Tau deposition in the mesial temporal lobe (MTL) in the absence of amyloid-β (Aβ−) occurs with aging. The tau PET tracer 18F-MK6240 has low non-specific background binding so is well suited to exploration of early-stage tau deposition. The aim of this study was to investigate the associations between MTL tau, age, hippocampal volume (HV), cognition, and neocortical tau in Aβ− cognitively unimpaired (CU) individuals.

Methods
One hundred and ninety-nine Aβ− participants (Centiloid < 25) who were CU underwent 18F-MK6240 PET at age 75 ± 5.2 years. Tau standardized uptake value ratio (SUVR) was estimated in mesial temporal (Me), temporoparietal (Te), and rest of the neocortex (R) regions and four Me sub-regions. Tau SUVR were analyzed as continuous variables and compared between high and low MTL SUVR groups.

Results
In this cohort with a stable clinical classification of CU for a mean of 5.3 years prior to and at the time of tau PET, MTL tau was visually observed in 9% of the participants and was limited to Braak stages I–II. MTL tau was correlated with age (r = 0.24, p < 0.001). Age contributed to the variance in cognitive scores but MTL tau did not. MTL tau was not greater with subjective memory complaint, nor was there a correlation between MTL tau and Aβ Centiloid value, but high tau was associated with smaller HV. Participants with MTL tau had higher tau SUVR in the neocortex but this was driven by the cerebellar reference region and was not present when using white matter normalization.

Conclusions
In an Aβ− CU cohort, tau tracer binding in the mesial temporal lobe was age-related and associated with smaller hippocampi, but not with subjective or objective cognitive impairment.
Application of exosomes in the diagnosis and treatment of pancreatic diseases
Authors: Han Li , Zhao Zhirong , Yang Ke , Xin Mei , Zhou Lichen , Chen Siping , Zhou Shibo , Tang Zheng , Ji Hua , Dai Ruiwu 
Published: April 2022

AbstractPancreatic diseases, a serious threat to human health, have garnered considerable research interest, as they are associated with a high mortality rate. However, owing to the uncertain etiology and complex pathophysiology, the treatment of pancreatic diseases is a challenge for clinicians and researchers. Exosomes, carriers of intercellular communication signals, play an important role in the diagnosis and treatment of pancreatic diseases. Exosomes are involved in multiple stages of pancreatic disease development, including apoptosis, immune regulation, angiogenesis, cell migration, and cell proliferation. Thus, extensive alterations in the quantity and variety of exosomes may be indicative of abnormal biological behaviors of pancreatic cells. This phenomenon could be exploited for the development of exosomes as a new biomarker or target of new treatment strategies. Several studies have demonstrated the diagnostic and therapeutic effects of exosomes in cancer and inflammatory pancreatic diseases. Herein, we introduce the roles of exosomes in the diagnosis and treatment of pancreatic diseases and discuss directions for future research and perspectives of their applications.
Timing shift-based bi-residual network model for the detection of electricity stealing
Authors: Lu Jie , Li Jingfu , Feng Wenjiang , Zou Yongqi , Zhang Juntao , Li Yuan 
Published: April 2022

AbstractWith the increasing number of electricity stealing users, the interests of countries are jeopardized and it brings economic burden to the government. However, due to the small-scale stealing and its random time coherence, it is difficult to find electricity stealing users. To solve this issue, we first generate the hybrid dataset composed of real electricity data and specific electricity stealing data. Then, we put forward the timing shift-based bi-residual network (TS-BiResNet) model. It learns the features of electricity consumption data on two aspects, i.e., shallow features and deep features, and meanwhile takes time factor into consideration. The simulation results show that TS-BiResNet model can detect electricity stealing behaviors that are small scaled and randomly coherent with time. Besides, its detection accuracy is superior to the benchmark schemes, i.e., long short-term memory (LSTM), gated recurrent unit (GRU), combined convolutional neural network and LSTM (CNN-LSTM) and Bi-ResNet.
An adaptive task scheduling algorithm for 3-D target imaging in radar network
Authors: Wang Dan , Zhang Qun , Luo Ying , Liu Xiaowen , Liang Jia 
Published: April 2022

AbstractAn effective task scheduling method is the premise and guarantee for cooperative imaging in radar network. In this article, an adaptive task scheduling algorithm for three-dimensional (3-D) target imaging in radar network is investigated. The aim of our strategy is to achieve the multiple 3-D target imaging tasks with the minimal task time. Firstly, the 3-D target image can be reconstructed by high-resolution inverse imaging aperture radar (ISAR) images from three views, and the sparse imaging algorithm based on compressed sensing (CS) is adopted to acquire the ISAR images of the targets. Then, the adaptive task scheduling optimization model is constructed. Through the steps of target Information perception, radar selection and adjustment of imaging terminal time, the optimal task scheduling strategy is obtained and the resource utilization of radar network is significantly improved. Finally, the experiments highlight the effectiveness of our proposed task scheduling method.
The existence of positive solutions for the Neumann problem of p-Laplacian elliptic systems with Sobolev critical exponent
Authors: Kou Bingyu , An Tianqing 
Published: April 2022

AbstractThe paper aims to consider a class of p-Laplacian elliptic systems with a double Sobolev critical exponent. We obtain the existence result of the above problem under the Neumann boundary for some suitable range of the parameters in the systems.
Optimal feedback control for fractional evolution equations with nonlinear perturbation of the time-fractional derivative term
Authors: Suechoei Apassara , Sa Ngiamsunthorn Parinya 
Published: April 2022

AbstractWe study the optimal feedback control for fractional evolution equations with a nonlinear perturbation of the time-fractional derivative term involving Caputo fractional derivatives with arbitrary kernels. Firstly, we derive a mild solution in terms of the semigroup operator generated by resolvents and a kernel from the general Caputo fractional operators and establish the existence and uniqueness of mild solutions for the feedback control systems. Then, the existence of feasible pairs by applying Filippov’s theorem is obtained. In addition, the existence of optimal control pairs for the Lagrange problem has been investigated.
The association of adolescent e-cigarette harm perception to advertising exposure and marketing type
Authors: Hung Man , Spencer Andrew , Goh Clarissa , Hon Eric S. , Cheever Val Joseph , Licari Frank W. , Moffat Ryan , Raymond Ben , Lipsky Martin S. 
Published: April 2022

Abstract
Background
Despite controversy over their possible health consequences, manufacturers of e-cigarettes employ a variety of marketing media to increase their popularity among adolescents. This study analyzed the relationship between adolescent e-cigarette harm perception and five types of e-cigarette advertising exposures: social media, radio, billboard, newspaper, and television.

Methods
This study used data from Wave 4.5 of the Population Assessment of Tobacco and Health Study (PATH). PATH collects demographic data and interview individuals about issues pertaining to tobacco use, health outcomes, attitudes, and behaviors. This study applied factor analysis to three individual PATH harm perception items to develop a composite harm perception score. Using linear regression, the study explored the relationship of harm perception and participant responses to their recalled viewing of five different types (i.e., newspaper, radio, billboard, television and social media) of advertisements within the past 30 days. A second analysis explored if adjusting for exposure to anti-tobacco messaging and environmental factors such as family approval mitigated the association of harm perception and advertisement types.

Results
The study sample consisted of 12,570 (weighted N = 23,993,149) individuals aged 12 to 17 years old. Unadjusted past 30-day exposure to newspaper, radio, billboard, and social media advertising all correlated with a reduced harm perception, but only the associations for newspaper and social media were statistically significant (p<0.05). After adjusting for environmental support factors, exposure to warning labels, and anti-tobacco advertisements, the analysis yielded statistically significant associations between increased e-cigarette harm perception and exposure to radio, billboard, and television advertisements (p<0.05). Adjusting for covariates also reduced the association of marketing and harm perception for all forms of media.

Conclusion
E-cigarette advertising influences adolescent perceptions of harm in e-cigarette use, particularly for social media and newspaper advertisements. This association weakens when adjusted for covariates such as environmental support and exposure to anti-tobacco marketing. These findings provide evidence for policy makers to continue anti-tobacco marketing and incorporate environmentally supportive strategies such as holistic, family-centered educational approaches to reduce e-cigarette use among adolescents.
Divergent responses of plant biomass and diversity to short-term nitrogen and phosphorus addition in three types of steppe in Inner Mongolia, China
Authors: Guo Ning , Xie Mingyang , Fang Zhao , Jiao Feng , Han Xiaoyu 
Published: April 2022

Abstract
Background
Understanding the response of the plant community to increasing nitrogen (N) and phosphorus (P) inputs is helpful for managing and protecting grassland ecosystems in semiarid areas. However, information about different types of steppe responses to N and P availability in semiarid grasslands is limited. In 2017–2018, two field experiments were conducted with six levels of N (from 5 to 30 g N m−2 yr−1) and P (from 2.5 g to 15 g P m−2 yr−1) additions in three different temperate steppes, including meadow steppe (MS), typical steppe (TS), and desert steppe (DS), in northern China to study the effects of these addition rates on community biomass and diversity.

Results
Our results showed that plant biomass and diversity in the three steppe types in Inner Mongolia responded differently to elevated N and P inputs. Increasing P promoted aboveground and belowground biomass more than increasing N in the three temperate steppes. Short-term N and P additions reduced plant diversity to some extent, with the most pronounced decreases in MS and DS. It is noteworthy that there were response thresholds for plant diversity and biomass in response to N and P inputs in different steppe types (e.g., 10 g P m−2 yr−1). Furthermore, redundancy analysis and stepwise regression analysis revealed that changes in soil properties induced by nutrient addition and climate conditions jointly regulated changes in vegetation biomass and diversity.

Conclusions
The plant biomass and diversity of three steppe types in Inner Mongolia respond divergently to elevated N and P inputs. Our results indicate that regional differences in climate and soil substrate conditions may jointly contribute to the divergent responses of plant biomass and diversity to short-term N and P addition. Our analyses provide new insights into managing and protecting grassland ecosystems. Considering that the effects of nutrient addition on plant diversity and productivity may have increasing effects over time, studies on long-term in situ nutrient addition are necessary.