bluuebunny/crossref_metadata_2025_split huggingface dataset:
Autosomal recessive spinocerebellar ataxia‐20 due to a novel SNX14 variant in an Indian girl
Authors: Sait Haseena , Moirangthem Amita , Agrawal Vinita , Phadke Shubha R. 
Published: February 2022

AbstractAutosomal recessive spinocerebellar ataxia‐20 is a rare disorder having distinctive coarse facies in addition to intellectual disability and cerebellar ataxia, with less than 35 cases reported worldwide. It is caused by biallelic variants in the SNX14 gene and is classified under the group of autophagy disorders. We report a 9‐year‐old girl who presented with classic clinical features of autosomal recessive spinocerebellar ataxia‐20 and cerebellar atrophy on magnetic resonance imaging of brain. Trio exome sequencing with Sanger confirmation revealed a novel splice site variant, c.140 + 3A > T in the SNX14 gene. The variant pathogenicity established by mRNA expression study showed a significant reduction in the expression levels of SNX14 gene in proband and her parents on comparison to the control. The electron microscopy of the skin fibroblasts of proband depicted numerous cytoplasmic vacuoles with variable degrees of dense staining material. In addition, we have briefly reviewed and compared the phenotypic features of published cases of autosomal recessive spinocerebellar ataxia‐20 in the literature. Coarse facies, intellectual disability with severe speech delay, hypotonia, and cerebellar atrophy were universal findings in the published cases. This is the second reported case from the Indian subcontinent.
Properties study of composites for polybutene‐1 and modified graphene oxide
Authors: Kou Jixiong , Duan Chenglong , Chen Yalan , Jia Yuanlong , Lu Siyuan , Wu Lei , Li Xingzhen , Wu Gang , Liu Chunli , Li Hui , Chen Zhenbin 
Published: February 2022

AbstractPolybutene‐1 (PB‐1) was wildly used as pipe and film with its excellent mechanical performance, great creep resistance even at high temperature, good machinability, and fillable performance. This work focused on studying the properties of composites for polybutene‐1 and modified graphene oxide (MGO). The graphene oxide (GO) was prepared using an improved Hummers method, and then it was modified with γ‐methylacryloxy propyl trimethoxysilane (KH570). After that, the obtained MGO was composited with PB‐1 by the solution blending method. The structure and properties of PB‐1 composites were investigated by Fourier transform infrared (FTIR), scanning electron microscope (SEM), X‐ray diffraction (XRD), thermogravimetric analysis (TGA), differential scanning calorimeter (DSC), universal material testing machine. The results showed that the MGO and PB‐1 presented good compatibility, and the addition of MGO could not change the crystal morphology of PB‐1. When the content of MGO was 0.75 wt% of PB‐1, the melt and crystallization temperatures were 127.5 and 70.5°C, and the strength of tensile and bending in the PB‐1/MGO composites was 27.58 and 674 MPa. Thus, the PB‐1/MGO composites have great potential for practical applications, such as in agricultural films and tubes.
Acupuncture for brain diseases: Conception, application, and exploration
Authors: Gao Xingzhou , Wang Yu , Meng Hong , Li Shaoyuan , Jiang Huili , Zhang Zixuan , He Jiakai , Zhao Yanan , Zhang Shuai , Zhai Weihang , Bao Tuya , Rong Peijing 
Published: February 2022

AbstractThe brain is probably the most complex organ in the human body. It has been the hot spot and direction of brain science research all over the world to deeply study the pathogenesis of various kinds of brain diseases and find effective treatment methods. Acupuncture is a nonpharmacological therapy of traditional Chinese medicine originating from ancient clinical practice. The research on the treatment of brain diseases by acupuncture has been constantly enriched and updated with the promotion of interdisciplinary research. In order to account for the current achievements in the field of acupuncture for brain diseases, this article reviews it in terms of conception, application, and exploration. Based on the literature review, we found that in the past decades, acupuncture has received widespread attention worldwide and many literatures have reported the clinical efficacy and underlying mechanisms of acupuncture in the treatment of brain diseases. Presently, the conception, application, and exploration of acupuncture in the treatment of brain diseases have evolved from empirical medicine to evidence‐based medicine and precision medicine, and are experiencing a deeper understanding of the information about acupuncture regulating the brain function based on interdisciplinary research.
Evolution of a discipline—The changing face of anatomy
Authors: Organ Jason M. , Comer Amber R. 
Published: February 2022

AbstractThis special issue is unlike any other special issue published in this journal's history. You will not find the types of original research in anatomy and evolutionary biology that you are accustomed to seeing adorning the pages of The Anatomical Record. Instead, the articles included cover the past and future of the discipline of anatomy broadly and of the American Association for Anatomy (AAA) more narrowly, and through two specific rhetorical frames: ethics; and diversity, equity, and inclusion. The articles in this issue are divided into two sections. The first section traces the history of anatomy and addresses many of the ethical dilemmas we face as a result of that history. The second section sets the stage for how the discipline and the AAA move forward to create a more diverse, equitable, and inclusive future for students, teachers, colleagues, and everyone else we touch through our work as anatomists. While this is only the beginning of our reconciliation with our past, the future certainly looks bright.
Entropy Stabilized Oxide Nanocrystals as Reaction Promoters in Lithium‐O2 Batteries
Authors: Hegde Guruprasad S. , Sundara Ramaprabhu 
Published: February 2022

AbstractCharge transport limitations at the Li2O2 discharge product‐electrode interfaces hinder the rechargeability of Li−O2 batteries. Herein, we introduce entropy stabilized oxides (ESO) as reaction ′promoters′ in positive electrodes that can facilitate charge transport by reducing the binding energy of the intermediates. In this work, we developed a rock‐salt type entropy stabilized oxide. We show that the rock salt phase transforms into a pure, equimolar, quinary spinel on heat treatment. A Li−O2 battery with the developed ESOs at the positive electrode is cycled with an areal capacity of 1 mAh cm−2 at a current rate of 0.25 mA cm−2 to study its role as a reaction promoter. The surface, bulk, and morphological characterization are carried out for both materials. The presence of multiple cations and defects on the surface of the ESO is found to benefit the discharge product oxidation and improve the cyclic stability.
Culture versus other sources of variance in risk and benefit perceptions: A comparison of Japan and the United States
Authors: Wang Yi , Highhouse Scott , Brooks Margaret 
Published: February 2022

AbstractTo what extent do countries and people within countries vary in their perceptions about the risks and benefits of engaging in risky activities? And to what extent are these variations influenced by risk domains? We used generalizability theory to identify and quantify the variance components in perceived risk and benefit ratings that are attributable to differences between cultures, across raters within cultures, and across risk domains. Our results, based on two archival datasets from the United States and Japan, revealed that, although there is nontrivial variability in risk and benefit perceptions between American and Japanese raters, the amount of variability was smaller between cultures compared with across raters within cultures. Moreover, investment risk perceptions and gambling benefit perceptions were predominantly influenced by differences across raters within cultures, and hence, large numbers of raters would be needed to properly represent ratings of the corresponding populations. Our findings suggest that variability in risk and benefit judgments across raters from different cultures should not be simply attributed to pure cultural differences. Rather, a multi‐faceted approach, where multiple sources of variance are simultaneously considered, should be adopted to properly understand and effectively influence judgments of risk and benefit.
Firm strategy and financial performance: What is the role of sustainability? Evidence from the banking system of an emerging market
Authors: Alketbi Osha Salem , Ellili Nejla Ould Daoud , Nobanee Haitham 
Published: February 2022

AbstractThis study investigated the moderating effect of sustainability performance (SP) on the relationship between firm strategy (FS) and financial performance (FP) in the context of the UAE's banking system. The data were obtained through the content analysis by using the annual reports of all listed commercial and Islamic banks of the UAE published from 2009 to 2019. By using panel data regression, the results showed that the FP of the banks is directly enhanced by the bank's strategy. The study also found that SP plays a moderating role in the relationship between FS and FP. However, it is revealed that if the bank's SP is high, FS does not have a statistically significant impact on FP. This finding is a significant contribution to strategy and sustainability literature as it highlights the moderating role played by SP in the relationship between FS and FP.
The effect of corporate environmental, social and governance disclosure on cash holdings: Life‐cycle perspective
Authors: Atif Muhammad , Liu Benjamin , Nadarajah Sivathaasan 
Published: February 2022

AbstractThis paper examines the impact of corporate environmental, social and governance (ESG) disclosure on cash holdings, specifically during various stages of the firm life cycle of S&P 1500 indexed firms. Using a sample of 9811 firm‐year observations from 2006 to 2015, we document a significantly negative relation between ESG disclosure and cash holdings in the introduction, growth and shake‐out/decline stages, and those lower cash holdings are associated with higher firm performance and a positive value of cash. Our findings are robust to alternative econometric specifications, alternative measures, additional control variables, propensity score matching and the use of an instrumental variable approach. Overall, our study offers useful insights into the global debate on ESG.
Focal epilepsy presenting as tongue tremor: A case report
Authors: Salari Mehri , Rezaei Kamran , Mirdehghan Alimohammad , Behzadi Arya , Etemadifar Masoud 
Published: February 2022

AbstractPlenty of etiologies are reported to cause tongue tremor. Focal epilepsy presenting as isolated tongue tremor is a rare condition, suggesting how variable the focal seizure presentation may be. This paper reports a case of focal epilepsy due to presence of a cavernous angioma in the region of cortical motor area related to tongue movements. It is an clinical example of pathological conditions affecting the tongue area in motor homunculus.
Metal‐Enabled Reactions of Nitrenes with Alkynes: Beyond Gold Catalysis
Authors: Ren Miaofeng , Wang Yu‐Chao , Ren Shangfeng , Huang Keke , Liu Jin‐Biao , Qiu Guanyinsheng 
Published: February 2022

AbstractAs versatile synthons, nitrenes have attracted great attention. Two research topics, including nitrene precursor development and nitrene‐based transformations, have been thoroughly investigated so far. Generally, different nitrene precursors under various metal catalysis have allowed for the differentiation of the reactivity of the resulting nitrene, thus enabling diverse C−H insertions, aziridinations, and sulfimidations with high reaction efficiency and reaction generality. Among the addition of nitrenes with unsaturated bonds, the reaction of nitrenes and alkynes is still in its initial stage, although various metal‐catalyzed transformations, typically, rhodium‐catalyzed sulfinamate‐derived nitrene/alkyne metalation, have been well‐developed. Two types of plausible mechanism, radical and electrophilic models, have been proposed. The simple preparation of acyl nitrenes and their enantioselective reaction with alkynes, as well as their applications in biologically interesting architectures, is of great interest. In this review, we would like to describe the reaction of nitrenes with alkynes under metal catalysis. To increase readability, this review will be presented according to mechanistic pathways and types of metal.
Rare‐earth Yttrium Exchanged Cu‐SSZ‐39 Zeolite with Superior Hydrothermal Stability and SO2‐Tolerance in NH3‐SCR of NOx
Authors: Yu Rui , Kong Haiyu , Zhao Zhenchao , Shi Chuan , Meng Xiangju , Xiao Feng‐Shou , De Baerdemaeker Trees , Parvulescu Andrei‐Nicolae , Müller Ulrich , Zhang Weiping 
Published: February 2022

AbstractWith the increasingly stringent restrictions on engine exhaust gases, efforts to enhance the activity, hydrothermal stability, and SO2‐tolerance of NH3‐SCR catalysts are highly desirable and challenging. Here, we present the concept of controlled sitings of the metal active sites by modifying Cu‐SSZ‐39 with yttrium (Y) as the rare‐earth metal for enhanced NH3‐SCR performances. Cu(0.25)‐Y(0.12)‐AEI(10) shows superior NOx conversion even after harsh hydrothermal aging at 900 °C, conditions under which standard Cu‐AEI cannot withstand. After long‐term SO2 poisoning, Cu(0.25)‐Y(0.12)‐AEI(10) shows a significantly higher NOx conversion than both Cu‐AEI and conventional Cu‐CHA. The structure‐activity correlation obtained from multiple characterizations, kinetics analyses and DFT calculations reveal that the Y ions act to inhibit dealumination during hydrothermal aging, as a sacrificial agent for SO2‐poisoning, and to stabilize catalytically active Cu centers within the zeolite framework. This synthesis concept provides insight into design of more stable and active NH3‐SCR catalysts in future.
Career practitioners’ response to career development concerns in the time of COVID‐19
Authors: Osborn Debra S. , Hayden Seth C. W. , Marks Laura Reid , Hyatt Tristen , Saunders Denise , Sampson James P. 
Published: February 2022

AbstractThe COVID‐19 pandemic has had a world‐wide impact on all areas of individuals’ health, including physical, psychological, financial, familial, social, and vocational. In the United States, the unemployment rate rose from 3.5% (5.8 million) to 13.3% (21 million) in May 2020 before dropping to 7.9% in October 2020. Cognitive information processing (CIP)is one career theory that addresses career needs of clients and society. In this article, we examine the impact of COVID‐19 on mental health and wellness, highlight differences for marginalized groups, and demonstrate how CIP theoretical elements may have been impacted by COVID‐19, and provide strategies enhancing client growth in these domains during a time when largescale social and physical distancing is recommended. The CIP‐based differentiated service delivery model is also described as a means for extending and providing access to career services.
Group career construction counseling with disadvantaged prospective university students
Authors: Maree J. G. , Jordaan Joyce , Hartung Paul J. 
Published: February 2022

AbstractWe investigated the value of a three‐phase, six‐step group‐based career construction counselling intervention for prospective university students from disadvantaged backgrounds using an integrative, QUALITATIVE‐quantitative design. The participants completed measures of career adaptability and career decision‐making difficulties before and after the intervention. Results indicated that the girls’ career adaptability scores increased more than those of the boys. Notable pretest and posttest score differences were also found for both the boys and the girls in all three main career decision‐making difficulties categories including Lack of Readiness, Lack of Information, and Inconsistent Information. While encouraging, longitudinal research with larger samples and more diverse participants in diverse contexts is necessary to more fully determine the value of the approach used here.
Disiloxanes Containing Tertiary Amine and Dioxaborolane Groups as Bifunctional Electrolyte Additive for Improved Cycling Life of LiNi0.8Co0.1Mn0.1O2/Graphite Batteries
Authors: Chen Cheng , Yan Xiaodan , Zhang Lingzhi 
Published: February 2022

AbstractA new disiloxane compound with tertiary amine and dioxaborolane group, N,N‐dimethyl‐2‐(3‐(1,1,3,3‐tetramethyl‐3‐(3‐(2‐(4,4,5,5‐tetramethyl‐1,3,2‐dioxaborolan‐2‐yl)ethoxy)propyl)disiloxanyl)propoxy)ethan‐1‐amine (TMBDSA), is designed and synthesized as functional electrolyte additive for improving the cycling stability of high‐capacity nickel‐rich LiNi0.8Co0.1Mn0.1O2 (NCM811). The NCM811/graphite full cell test shows that the cycling stability is considerably improved by adding TMBDSA (0.2 wt.%) in the baseline electrolyte, retaining 88 % of initial capacity as compared with 71 % for the cell with the baseline electrolyte at 1 C after 200 cycles. Even at a high rate of 10 C, the cell with TMBDSA delivers a high capacity of 140.2 mAh/g and outstanding cycling stability at high temperatures of 55 °C. The surface analysis and density functional theory calculation reveal that TMBDSA is oxidized prior to the carbonate components in the electrolyte to form a protective interphase layer on the cathode surface. In addition, TMBDSA can significantly suppress the hydrolysis of LiPF6 and the dissolution of transition metal ions (Ni, Co, and Mn) owing to the acid scavenging function of tertiary amine moiety. All the results demonstrate that TMBDSA can be potentially used as an efficient electrolyte additive for improving the cycling life of high energy density lithium‐ion batteries using nickel‐rich NCM811 cathode.
Pd‐Modified De‐alloyed Au−Ni‐Microelectrodes for In Situ and Operando Mapping of Hydrogen Evolution
Authors: Kund Julian , Romer Jan , Oswald Eva , Gaus Anna‐Laurine , Küllmer Maria , Turchanin Andrey , von Delius Max , Kranz Christine 
Published: February 2022

AbstractTo date most studies focusing on light‐driven water splitting for green energy conversion schemes depend on bulk analyses of the produced hydrogen using, e. g., head‐space gas chromatography. In this contribution, we present the fabrication of Pd‐modified microelectrodes for in situ electrochemical hydrogen measurements using de‐alloyed Au−Ni microelectrodes. Stability studies and pH‐dependent investigations revealed the stability of these microsensors over a period of seven days, and confirmed their applicability in a pH range of 3–10 with a limit of detection (LOD)<1 μmol/L. First in situ proof‐of‐principle electrochemical imaging of hydrogen generated at a microelectrode and operando studies of hydrogen evolution at earth‐abundant cobalt hydrogen evolution catalysts using the developed Pd‐microsensors in combination with scanning electrochemical microscopy (SECM) demonstrated the potential of these microsensors for operando studies in light‐driven heterogeneous catalysis.
Rational Optimization of Dihydropyrimidinone‐Quinoline Hybrids as Plasmodium falciparum Glutathione Reductase Inhibitors
Authors: Adigun Rasheed A. , Malan Frederick P. , Balogun Mohammed O. , October Natasha 
Published: February 2022

AbstractA series of dihydropyrimidinone‐based antimalarial compounds were designed and synthesised based on the previously identified amide‐based quinoline hybrids which showed good resistance reversal ability against the resistant strain of Plasmodium falciparum. The aromatic ring on the dihydropyrimidinone of the original hits was exchanged for a methyl group to bring the molecular weights below 500 Da and also determine the effect of the aromatic ring count on the resistance reversal ability of the hybrids. Apart from the previously used amide bond, the hybrid linker was also extended to the triazole linker. Although the triazole linker is synthetically easier to access, the use of an amide linker seems to have an activity advantage. The synthesised compounds in addition to the previously identified hits were subjected to molecular docking particularly targeting the orthosteric site of Plasmodium falciparum glutathione reductase (PfGR) protein. The ligand with the best binding interaction was rationally optimised to increase its suitability as a competitive inhibitor against the cofactor of the PfGR. Two of the optimised ligands showed better binding affinities than the cofactor while one of the two ligands displayed hydrophobically packed correlated hydrogen‐bond which is very important in maintaining the ligand stability within the protein. In silico ADME predictions of the synthesised compounds indicate that these compounds possess good pharmacokinetic properties.
Secondary malignant neoplasms after bone and soft tissue sarcomas in children, adolescents, and young adults
Authors: Kube Stefanie J. , Blattmann Claudia , Bielack Stefan S. , Kager Leo , Kaatsch Peter , Kühne Thomas , Sorg Benjamin , Kevric Matthias , Jabar Susanne , Hallmen Erika , Sparber‐Sauer Monika , Klingebiel Thomas , Koscielniak Ewa , Dirksen Uta , Hecker‐Nolting Stefanie , Gerß Joachim W. O. 
Published: February 2022

BackgroundIncreased survival in young sarcoma patients comes along with a higher incidence of second malignant neoplasms (SMNs). The incidence, latency, histiotype, and outcome of these patients were analyzed because this information is essential to design evidence‐based long‐term follow‐up care programs for young sarcoma survivors.MethodsPatients entered on clinical trials or registered in registries with a primary sarcoma in 1 of the cooperative sarcoma study groups in the framework of the Society for Pediatric Oncology and Hematology (GPOH) were screened for SMNs. Descriptive analysis, the Kaplan‐Meier method, the Gray model, the Fine‐Gray model, and the Cox regression model were used for the statistical analyses.ResultsA total of 159 out of 7079 (2.2%) patients were registered with a SMN. Among them, 104 solid SMNs (65%) and 56 hematologic SMNs (35%) occurred. Median latency from first diagnosis of sarcoma to the diagnosis of SMN was 6.8 years (range, 0‐26.7 years). Cumulative incidence of SMN was 8.8% after 30 years. Five‐year‐survival was 67.1% (95% confidence interval [CI], 66.0‐68.2) for the 7079 patients and it was 45.1% (95% CI, 36.2‐53.6) after the diagnosis of a SMN (subcohort of n = 159 patients).ConclusionsThere is a remarkable high cumulative incidence of SMNs after bone and soft tissue sarcomas in children, adolescents, and young adults. Therefore, effective transition as well as risk adapted long‐term follow‐up care programs should be developed and offered to young sarcoma survivors.Lay Summary

Bone sarcomas and soft tissue tumors are rare tumors in children, adolescents, and young adults.

The treatment varies, but may comprise chemotherapy, surgery, and/or radiotherapy.

Developing a subsequent malignant tumor is a long‐term risk for the patients.

To better characterize this risk, we analyzed the data of 7079 patients (up to 21 years old) with bone sarcomas or soft tissue tumors.

Our findings provide a basis to counsel young sarcoma survivors on their individual risk of subsequent malignant tumors.

Moreover, these data can help to establish recommendations for aftercare in young sarcoma survivors.