bluuebunny/crossref_metadata_2025_split huggingface dataset:
Peripheral non-enzymatic antioxidants as biomarkers for mood disorders: Evidence from a machine learning prediction model
Authors: Gong Yuandong , Lu Zhe , Kang Zhewei , Feng Xiaoyang , Zhang Yuyanan , Sun Yaoyao , Chen Weimin , Xun Guanglei , Yue Weihua 
Published: November 2022

BackgroundOxidative stress is related to the pathogenesis of mood disorders, and the level of oxidative stress may differ between bipolar disorder (BD) and major depressive disorder (MDD). This study aimed to detect the differences in non-enzymatic antioxidant levels between BD and MDD and assess the predictive values of non-enzymatic antioxidants in mood disorders by applying a machine learning model.MethodsPeripheral uric acid (UA), albumin (ALB), and total bilirubin (TBIL) were measured in 1,188 participants (discover cohort: 157 with BD and 544 with MDD; validation cohort: 119 with BD and 95 with MDD; 273 healthy controls). An extreme gradient boosting (XGBoost) model and a logistic regression model were used to assess the predictive effect.ResultsAll three indices differed between patients with mood disorders and healthy controls; in addition, the levels of UA in patients with BD were higher than those of patients with MDD. After treatment, UA levels increased in the MDD group, while they decreased in the BD group. Finally, we entered age, sex, UA, ALB, and TBIL into the XGBoost model. The area under the curve (AUC) of the XGBoost model for distinguishing between BD and MDD reached 0.849 (accuracy = 0.808, 95% CI = 0.719–0.878) and for distinguishing between BD with depression episode (BD-D) and MDD was 0.899 (accuracy = 0.891, 95% CI = 0.856–0.919). The models were validated in the validation cohort. The most important feature distinguishing between BD and MDD was UA.ConclusionPeripheral non-enzymatic antioxidants, especially the UA, might be a potential biomarker capable of distinguishing between BD and MDD.
Assessment of psychometric properties of the self-stigma inventory for Iranian families of persons who use drugs
Authors: Dinmohammadi Mohammadreza , Jalali Amir , Naderipour Arsalan 
Published: November 2022

BackgroundSubstance use disorder (SUD) and its related problems take a toll on the individual, family, and society. This study was conducted to determine the psychometric properties of the self-stigma scale in the families of persons who use drugs (PWUDs) in Iran.MethodsThis was a methodological and psychometric study. The study population consisted of 311 family members of PWUDs visiting outpatient and inpatient addiction treatment centers in Kermanshah who were selected using convenience sampling. The 14-item Self-Stigma Inventory for Families (SSI-F), which was developed by Yildiz et al. in 2019 using interviews and scales connected with stigma, was applied. The ten steps developed by Wilde et al. were used in this study for cultural validation. The exploratory factor analysis (EFA) (140 samples) and confirmatory factor analysis (CFA) (311 subjects) were used to confirm the construct validity, and the test-retest method was used to confirm the reliability of the tools. Cronbach's alpha was also used to test the internal consistency of the tools.FindingsThe results of EFA and CFA scales in families of PWUDs were confirmed with three factors and 14 items. The reliability degree of the tools was confirmed as 0.891 and the Cronbach's alpha was confirmed as 0.879 using the test-retest method. Pearson's correlation coefficient indicated a positive and significant status between the scale's items/factors and the scale itself.ConclusionGenerally, the results showed that the PWUDs SSI-F scale in Iranian families was valid and reliable with three factors and 14 items, and it can be used to conduct relevant studies.
Peripheral blood cytokines as potential diagnostic biomarkers of suicidal ideation in patients with first-episode drug-naïve major depressive disorder
Authors: Xu Yayun , Liang Jun , Gao Wenfan , Sun Yanhong , Zhang Yuanyuan , Shan Feng , Ge Jinfang , Xia Qingrong 
Published: November 2022

ObjectiveMajor Depressive Disorder (MDD) is a leading cause of disability, with a high risk of suicidal ideation (SI). Few studies have evaluated the potential of multiple cytokines as biomarkers for SI in patients with MDD. In the present study, we examined the serum levels of multiple cytokines in patients with first-episode drug-naïve MDD, with the aim to discover and identify serum cytokines-based biomarkers for identification of SI in MDD.MethodsA total of 55 patients with first-episode drug-naïve MDD were enrolled and divided into two groups: 26 MDD patients without SI and 29 MDD patients with SI. Beck Scale for Suicide Ideation was used to estimate SI. A total of 37 cytokines were measured using Multiplex Luminex Assays. The levels of serum cytokines between MDD patients without SI and MDD patients with SI were compared and diagnostic values of different cytokines were evaluated using the receiver operating characteristic (ROC) curve method for discriminating MDD patients with SI from MDD patients without SI. The relationship between the group and the abnormal cytokines were investigated in multiple linear regression models, with adjustments for age, gender, BMI, smoking, and Hamilton Depression Rating Scale-24 (HAMD-24) scores.ResultsThe levels of CCL26 and VEGF in MDD patients with SI were significantly lower than those in MDD patients without SI (all P &lt; 0.05). On the contrary, the levels of IL-17C, CXCL10, and TNF-β in MDD patients with SI were significantly higher than those in MDD patients without SI (all P &lt; 0.05). Moreover, the results of multiple linear regression revealed that group was a significant independent predictor of serum IL-17C, CCL-26, VEGF, and TNF-β levels (all P &lt; 0.05). In terms of CXC10, group was also likely to be a significant independent predictor (β = 0.257, P = 0.063). Furthermore, the AUC values of IL-17C and TNF-β were 0.728 and 0.732, respectively. Additionally, a combined panel of IL-17C and TNF-β achieved a high accuracy in discriminating MDD patients with SI from MDD patients without SI (AUC = 0.848, sensitivity = 75.9%, specificity = 72.7%).ConclusionsThese results suggested that circulating IL-17C and TNF-β may hold promise in the discovery of biomarkers for identification of SI in MDD.
Toward the upscaling of school nutrition programs in Dubai: An exploratory study
Authors: AlGurg Reem , Abu Mahfouz Nour , Otaki Farah , Alameddine Mohamad 
Published: November 2022

BackgroundSchool nutrition programs impact the intellectual, social, and emotional development of school children, as well as their future risk of developing Non-Communicable Diseases. While many stakeholders are involved in the development, implementation, and evaluation of school nutrition programs in Dubai, United Arab Emirates, little is known about the complementarity among those stakeholders, and the means to upscale school nutrition programs while ensuring effective, efficient, and equitable implementation. Accordingly, this study aims at exploring the perceptions of a diverse group of stakeholders, positioned at differing levels of the public health and education ecosystems in the United Arab Emirates, in relation to current guidelines and practices around the planning, implementation, and evaluation of school nutrition programs in Dubai, United Arab Emirates.MethodsThe current study relied on a qualitative design, based on semi-structured key informant interviews. A total of 29 interviews were carried out. Those interviewees included leaders and directors from different institutions, decision- and policy- makers, nutritionists and dieticians, school nurses and nurse managers, and school principals and vice principals. All stakeholders were interviewed by the research team. Data was transcribed, and then thematically analyzed using the health systems' model as an analytic framework.ResultsThe thematic analysis of interview data identified five interrelated themes. The first theme relates to the limited coordination across regulatory local and federal entities, and the multiplicity of guidelines issued by the different stakeholders. The challenges around the human and financial resourcing of school nutrition programs constituted the second theme. The third theme was the weakly coordinated implementation efforts. The fourth theme was the need for better performance measurement, and the fifth theme flagged the need for improved inclusiveness for health needs and cultural preferences of the diverse student body in Dubai (given that there are citizens from more than 200 nationalities co-existing in Dubai).ConclusionThis study emphasizes that all the involved stakeholders need to better collaborate to upscale the school nutrition program in Dubai. This will require the formation of a unified governing body, which would identify and develop a single stream of resources, and sets in place a reliable, all encapsulating and equitable implementation plan along with an overarching monitoring and evaluation framework.
Survival of a patient with multiple-recurrent giant retroperitoneal dedifferentiated liposarcoma for 15 years: A case report
Authors: Xia Hao , Fang Fang , Yuan Haijuan , Tu Yimei 
Published: November 2022

BackgroundRetroperitoneal liposarcoma (RPLS) is a variety of soft tissue sarcoma that originates from mesenchymal cells. A tumor measuring greater than 30 cm is called a “giant liposarcoma.” A part of the neoplasm tends to grow in size, recur locally, or metastasize distantly. In those with such a condition, long-term survival is uncommon. Therefore, it is necessary to present a uniform and optimized program to improve the prognosis.MethodsBy successfully treating a multiple-recurrent giant retroperitoneal dedifferentiated liposarcoma (RP DDLPS) in July 2010, we hope to devise more comprehensive strategies to improve diagnosis, therapy, and outcome.ResultsIn July 2010, we thoroughly resected a giant multifocal RPLS with a concomitant part of the gastric wall. The histopathological examination revealed a high-grade (grade III) dedifferentiated liposarcoma. The patient was discharged uneventfully on the 15th postoperative day. She relapsed after 16 months and needed another complete excision. After 9 months, she died after the fourth recidive. The patient had experienced four recurrences and underwent operations with 15 years of follow-up.ConclusionsThe above demonstrates that we were able to successfully treat the multirecurrent giant RPLS, despite the patient’s poor medical condition, with meticulous management. Moreover, this indicates that long-term survival could be achieved for high-grade RP DDLPS.
A Novel Glycolysis-Related Long Noncoding RNA Signature for Predicting Overall Survival in Gastric Cancer
Authors: Zeng Jianmin , Li Man , Dai Kefan , Zuo Bingyu , Guo Jianhui , Zang Lu 
Published: November 2022

Background: The aim of this study was to construct a glycolysis-related long noncoding RNA (lncRNA) signature to predict the prognosis of patients with gastric cancer (GC).Methods: Glycolysis-related genes were obtained from the Molecular Signatures Database (MSigDB), lncRNA expression profiles and clinical data of GC patients were obtained from The Cancer Genome Atlas database (TCGA). Furthermore, univariate Cox regression analysis, Least Absolute Shrinkage and Selection Operator (LASSO) and multivariate Cox regression analysis were used to construct prognostic glycolysis-related lncRNA signature. The specificity and sensitivity of the signature was verified by receiver operating characteristic (ROC) curves. We constructed a nomogram to predict the 1-year, 3-year, and 5-year survival rates of GC patients. Besides, the relationship between immune infiltration and the risk score was analyzed in the high and low risk groups. Multi Experiment Matrix (MEM) was used to analyze glycolysis-related lncRNA target genes. R “limma” package was used to analyze the mRNA expression levels of the glycolysis-related lncRNA target genes in TCGA. Gene set enrichment analysis (GSEA) was employed to further explore the biological pathways in the high-risk group and the glycolysis-related lncRNA target gene.Results: A prognostic signature was conducted based on nine glycolysis-related lncRNAs, which are AL391152.1, AL590705.3, RHOXF1-AS1, CFAP61-AS1, LINC00412, AC005165.1, AC110995.1, AL355574.1 and SCAT1. The area under the ROC curve (AUC) values at 1-year, 3-year, and 5-year were 0.765, 0.828 and 0.707 in the training set, and 0.669, 740 and 0.807 in the testing set, respectively. In addition, the nomogram could efficaciously predict the 1-year, 3-year, and 5-year survival rates of the GC patients. Then, we discovered that GC patients with high-risk scores were more likely to respond to immunotherapy. GSEA revealed that the signature was mainly associated with the calcium signaling pathway, extracellular matrix (ECM) receptor interaction, and focal adhesion in high-risk group, also indicated that SBSPON is related to aminoacyl-tRNA biosynthesis, citrate cycle, fructose and mannose metabolism, pentose phosphate pathway and pyrimidine metabolism.Conclusion: Our study shows that the signature can predict the prognosis of GC and may provide new insights into immunotherapeutic strategies.
Isotherm, Kinetic, and Selectivity Studies for the Removal of 133Ba and 137Cs from Aqueous Solution Using Turkish Perlite
Authors: İnan Süleyman , Kusumkar Vipul Vilas , Galamboš Michal , Viglašová Eva , Rosskopfová Oľga , Daňo Martin 
Published: November 2022

The efficiency of 133Ba and 137Cs removal from aqueous solution is vital to mitigate ecological concerns over spreading these radionuclides in the environment. The present work focused on the use of Turkish perlite for the sorptive removal of 133Ba and 137Cs from aqueous solution by the radioindicator method. Perlite was characterized by XRF, XRD, FTIR, SEM–EDX, and BET analyses. The maximum percentage removals of 88.2% and 78.7% were obtained for 133Ba and 137Cs at pH 6 and pH 9, respectively. For both ions, the sorption equilibrium was attained relatively rapidly. Experimental kinetic data were well described with pseudo-second-order and intraparticle diffusion models. The uptake of both ions increased with the increase in metal concentration (1 × 10−5 to 5 × 10−2 mol/L) in solution. The maximum uptake capacities of 133Ba and 137Cs were found to be 1.96 and 2.11 mmol/g, respectively. The effect of competing ions decreased in the order of Ca2+>K+>Ni2+>Na+ for 133Ba sorption, whereas for 137Cs sorption, the order was determined as Ca2+>Ni2+>K+>Na+. Selectivity studies pointed out that sorption of 133Ba onto perlite is preferable to 137Cs. Therefore, Turkish perlite is a promising, cost-effective, and efficient natural material for the removal of 133Ba and 137Cs from relatively diluted aqueous solution.
New Hille Type and Ohriska Type Criteria for Nonlinear Third-Order Dynamic Equations
Authors: Hassan Taher S. , Kong Qingkai , El-Nabulsi Rami Ahmad , Anukool Waranont 
Published: November 2022

The objective of this paper is to derive new Hille type and Ohriska type criteria for third-order nonlinear dynamic functional equations in the form of a2(ζ)φα2a1ζφα1xΔ(ζ)ΔΔ+q(ζ)φαx(g(ζ))=0, on a time scale T, where Δ is the forward operator on T, α1, α2, α>0, and g, q, ai, i = 1, 2, are positive rd-continuous functions on T, and φθ(u):=uθ−1u. Our results in this paper are new and substantial for dynamic equations of the third order on arbitrary time scales. An example is included to illustrate the results.
Evaluation of Aurantiochytrium mangrovei Biomass Grown on Digestate as a Sustainable Feed Ingredient of Sea Bass, Dicentrarchus labrax, Juveniles and Larvae
Authors: Soudant Philippe , Ventura Mariana , Chauchat Luc , Guerreiro Maurean , Mathieu-Resuge Margaux , Le Grand Fabienne , Simon Victor , Collet Sophie , Zambonino-Infante José-Luis , Le Goïc Nelly , Lambert Christophe , Fernandes Fleuriane , Silkina Alla , de Souza Marcella Fernandes , de la Broise Denis 
Published: November 2022

The use of microalgae as a sustainable source of n-3 long-chain polyunsaturated fatty acids (LC-PUFA) as an alternative to fish oils from small pelagic fish (e.g., anchovy, sardine) has received growing interest in the past few years. The present study aimed to: (i) produce Aurantiochytrium mangrovei biomass by heterotrophic fermentation using a medium containing anaerobic digestion liquid effluent, and (ii) evaluate a biomass rich in n-3 LC-PUFA and good quality proteins as a feed ingredient for sea bass juveniles and larvae. Two 800 L bioreactors were used to produce Aurantiochytrium biomass in non-axenic conditions. Biomass was then filtered through a crossflow filtration system (300 Kda ceramic membrane) and freeze-dried. Sea bass juveniles (32.7 ± 4.2 g) were fed both a control diet and a diet containing 15% of freeze-dried A. mangrovei biomass for 38 days. Juvenile survival percentage was 90% on average in both dietary conditions. Similar growth was observed between fish fed with both diets, demonstrating the feasibility to replace 15% of a standard fish feed by Aurantiochytrium biomass. The liver of sea bass juveniles fed with the A. mangrovei diet contained significantly higher proportions of 22:6n-3, 22:5n-6, and 20:4n-6 than those fed with the control diet, while the proportions of 16:0, 16:1n-7, and 18:1n-9 were significantly lower. The secondary oxidation, as measured by malonylaldehyde (MDA) content, in the liver and muscle of juveniles fed with the microalgae diet tended to be higher than in fish fed the control diet, but the differences were not statistically significant. Although the larvae survival percentage was low for all the tanks after 41 days of rearing, the inclusion of 15% of hydrolyzed A. mangrovei biomass in the larvae micro-diet did not impair the development of sea bass larvae and only marginally affected their lipid composition. In the future, we have to further optimize a sustainable workflow between Aurantiochytrium cultivation and fish feed production and confirm the zootechnical and biochemical results.
Kajian Penumbuhan Kawasan Strategis Tanjungsari Dan Pakunden Kota Blitar
Authors: Sari Nindya , Shofarini Dian Indah 
Published: November 2022

Sebagai kota dengan beragam daya tarik wisata, Kota Blitar menerima kunjungan wisatawan dari dalam Kota Blitar maupun luar Kota Blitar. Wisatawan dari luar Kota Blitar pada umumnya melewati Kelurahan Tanjungsari dan Pakunden sebagai pintu masuk ke Kota Blitar dari arah barat. Kedua kelurahan ini merupakan bagian dari BWP IV (RDTR BWP Kota Blitar 2017-2037) dan direncanakan untuk pengembangan agrowisata. Penelitian ini bertujuan untuk mengidentifikasi potensi lokasi Kelurahan Tanjungsari dan Kecamatan Pakunden sebagai penunjang pariwisata di Kota Blitar dengan menggunakan metode deskriptif dan mengoptimalkannya menggunakan matriks Strenghts, Weaknesses, Opportunities and Threats (SWOT). Berdasarkan hasil analisis, konsep pengembangan kawasan Kelurahan Tanjungsari dan Pakunden dapat direncanakan sebagai Kawasan Pendukung Kegiatan Pariwisata di Kota Blitar. Arahan pengembangan berikut dilakukan sesuai dengan rencana kegiatan pengembangan, antara lain mengembangkan konektivitas dengan daya tarik wisata utama di Kota Blitar, menumbuhkan showroom produk khas daerah, dan mengembangkan berbagai kegiatan pariwisata berbasis potensi daerah.
Kajian Aspek Fonologis Pemerolehan Bahasa Anak Usia Dini Di Kampung Setro Kota Surabaya
Authors: Dewi Kiki Ananda Dewi , Widayati Wahyu , Tobing Victor Maroli Tua 
Published: November 2022

Abstrak
Kemampuan berbahasa pada anak diperoleh pertama kali pada usia dini. Tentunya kemampuan tersebut didasarkan pada pemerolehan fonologi pada anak. Pemerolehan fonologi pada anak usia dini menjadi berbeda bunyinya akibat dari keterbatasan pada alat ucapnya. Hal tersebut didasarkan karena pada usia dua hingga tiga tahun organ wicara pada anak belum matang sempurna, sehingga ujaran yang diproses menjadi berbeda bentuk, yaitu berubah, bertambah, atau berkurang. Proses pemerolehan fonologi tentu berhubungan erat dengan teori pemerolehan fonologi. Salah satu teori yang terdapat dalam pemerolehan fonologi adalah teori proses fonologi alamiah yang memiliki ciri khas menindas, membatasi, dan mengatur. Tujuan dilaksanakan penelitian ini, yaitu untuk mendeskripsikan penindasan, pembatasan, dan pengaturan pada pemerolehan fonologi anak usia dini 2-3 tahun. Jenis penelitian ini adalah penelitian kualitatif dengan data berbentuk kata dari ujaran anak usia dini. Metode penelitian yang digunakan ada dua, yaitu metode simak dan metode catat. Sedangkan metode analisis data yang digunakan adalah metode padan. Hasil dari penelitian ini mengacu pada teori Stampe mengenai pemerolehan fonologi, yaitu terjadi penindasan pada fonem homorgan, terjadi pembatasan pada fonem hambat tegang, dan terjadi pengaturan pada proses produksi fonem sukar

Abstract
Language skills in children are obtained for the first time at an early age. Of course, this ability is based on the acquisition of phonology in children. The acquisition of phonology in early childhood becomes different in sound as a result of limitations in the speech apparatus. This is based on the fact that at the age of two to three years, the speech organs in children are not yet fully mature, so the processed speech becomes different forms, namely changing, increasing, or decreasing. The process of acquiring phonology is certainly closely related to the theory of phonological acquisition. One of the theories contained in the acquisition of phonology is the theory of natural phonological processes which have the characteristics of oppressing, limiting, and regulating. The purpose of this research is to describe the suppression, limitation, and regulation in the acquisition of phonology for early childhood 2-3 years. This type of research is a qualitative research with data in the form of words from the speech of early childhood. There are two research methods used, namely the listening method and the note-taking method. While the data analysis method used is the equivalent method. The results of this study refer to Stampe's theory of phonological acquisition, namely suppression of homoorganic phonemes, restrictions on tense inhibitory phonemes, and regulation of the production process of difficult phonemes.
FORMULASI SEDIAAN CREAM DAN UJI AKTIVITAS ANTIBAKTERI PADA EKSTRAK ETANOL KOMBINASI KULIT PISANG (Musa paradisiaca) DAN KULIT NANAS (Ananas comosus) TERHADAP BAKTERI PENYEBAB JERAWAT Propionibacterium acnes
Authors: Sembiring Pintata 
Published: November 2022

Background: Acne vulgaris is a chronic inflammatory skin disease with a complex pathogenesis, involving sebaceous glands, follicular hyperkeratosis, bacterial overgrowth, immune and inflammatory responses. Objective: This formulate the ethanol extract of banana peel and pineapple peel into cream preparations and to test the effective antibacterial activity of the combination of banana peel and pineapple peel ethanol extract cream against Propionibacterium acnes. Methods: This research was conducted experimentally with maceration extraction using 70% ethanol as solvent. Acne cream is made with a concentration ratio between (Banana peel: Pineapple peel) namely F1 (Cream Base), F2 (5%:15%), F3 (7.5%:12.5%), F4 (10%:10% ), F5 (12.5%:7.5%), F6 (15%;5%), F7 (20%:0%) and F8 (0%;20%). Then, the physical stability test was carried out in the form of organoleptic test, viscosity test, pH test, homogeneity test, spreadability test and cream type test. Followed by testing the bacteria Propionibacterium acnes in Na media. Results: The antibacterial activity test on F3 showed that the diameter of 20.18 mm was relatively larger than F1 of 0mm, F2 of 18.63 mm, F4 of 18.38 mm, F5 of 16.48 mm, F6 of 18.28 mm, F7 of 13.91 mm and The F8 is 16.11 mm. Conclusion: Cream preparations from formula 1 to formula 8 the cream stability organoleptic test, viscosity test, pH test, homogeneity test, test spreadability and cream type test. The cream preparation in formula 3 has the widest diameter for antibacterial activity compared to other formulas.