bluuebunny/crossref_metadata_2025_split huggingface dataset:
Colloidal lithography as a novel approach for the development of Ni-nanocavity insulin sensor
Authors: Šišoláková Ivana , Petruš Ondrej , Shepa Jana , Farka Zdeněk , Oriňak Andrej , Oriňaková Renáta 
Published: June 2022

AbstractIn this study, a highly sensitive, fast, and selective enzyme-free electrochemical sensor based on the deposition of Ni cavities on conductive glass was proposed for insulin detection. Considering the growing prevalence of diabetes mellitus, an electrochemical sensor for the determination of insulin was proposed for the effective diagnosis of the disease. Colloidal lithography enabled deposition of nanostructured layer (substrate) with homogeneous distribution of Ni cavities on the electrode surface with a large active surface area. The morphology and structure of conductive indium tin oxide glass modified with Ni cavities (Ni-c-ITO) were characterized by scanning electron microscopy (SEM) and atomic force microscopy (AFM). The diameter of the resulting cavities was approximately 500 nm, while their depth was calculated at 190 ± 4 nm and 188 ± 18 nm using AFM and SEM, respectively. The insulin assay performance was evaluated by cyclic voltammetry. Ni-c-ITO exhibited excellent analytical characteristics, including high sensitivity (1.032 µA µmol−1 dm3), a low detection limit (156 µmol dm−3), and a wide dynamic range (500 nmol dm−3 to 10 µmol dm−3). Finally, the determination of insulin in buffer with interferents and in real blood serum samples revealed high specificity and demonstrated the practical potential of the method.
Genome-wide identification and characterization of long noncoding RNAs during peach (Prunus persica) fruit development and ripening
Authors: Zhou Hui , Ren Fei , Wang Xiao , Qiu Keli , Sheng Yu , Xie Qingmei , Shi Pei , Zhang Jinyun , Pan Haifa 
Published: June 2022

AbstractLncRNAs represent a class of RNA transcripts of more than 200 nucleotides (nt) in length without discernible protein-coding potential. The expression levels of lncRNAs are significantly affected by stress or developmental cues. Recent studies have shown that lncRNAs participate in fruit development and ripening processes in tomato and strawberry; however, in other fleshy fruits, the association between lncRNAs and fruit ripening remains largely elusive. Here, we constructed 9 ssRNA-Seq libraries from three different peach (Prunus persica) fruit developmental stages comprising the first and second exponential stages and the fruit-ripening stage. In total, 1500 confident lncRNAs from 887 loci were obtained according to the bioinformatics analysis. The lncRNAs identified in peach fruits showed distinct characteristics compared with protein-coding mRNAs, including lower expression levels, lower complexity of alternative splicing, shorter isoforms and smaller numbers of exons. Expression analysis identified 575 differentially expressed lncRNAs (DELs) classified into 6 clusters, among which members of Clusters 1, 2, 4 and 5 were putatively associated with fruit development and ripening processes. Quantitative real-time PCR revealed that the DELs indeed had stage-specific expression patterns in peach fruits. GO and KEGG enrichment analysis revealed that DELs might be associated with fruit-ripening-related physiological and metabolic changes, such as flavonoid biosynthesis, fruit texture softening, chlorophyll breakdown and aroma compound accumulation. Finally, the similarity analysis of lncRNAs within different plant species indicated the low sequence conservation of lncRNAs. Our study reports a large number of fruit-expressed lncRNAs and identifies fruit development phase-specific expressed lncRNA members, which highlights their potential functions in fruit development and ripening processes and lays the foundations for future functional research.
Upgrading structure existing components using multiple UHPC-class materials
Authors: Mikutaite Vita , Donchev Ted , Petkova Diana , Haroglu Hasan 
Published: June 2022

Durability and mechanical properties of UHPC help to develop solutions to upgrade structures. Cementitious UHPC concrete has a minimum specified compressive strength (120-150 MPa), superior resistance to compression, ductility, eco-efficiency and insulation. It is usually used with fibres included to achieve the specified requirements of the mixture. Sprayable UHPC types for inclined applications and leave leave-in-place form solutions have been developed and are used for repair and strengthening purposes.
A combination of UHPC and post tensioning is used to create an optimal reinforcement solution. UHPC represented an innovation in post-tensioning for the first time in the United Kingdom, creating a possibility to cast anchoring blocks that are compact, aesthetically pleasing and safer to install. Prefabricated anchors for the bridge exterior and anchors poured on site for the bridge interior were used.
UHPC-steel composite deck is an effective solution to improve a steel bridge’s strength and stiffness. Studies of overlays in bridge decks showed that UHPC substrates exhibit a higher bond strength than normal strength concrete (NSC) and further analysis of techniques for bonding surfaces with UHPC.
Future tendencies about structure improvements using UHPC and GFRP are reviewed.
Plasmodium vivax – eine langfristige Parasitose?
Authors: Rieke Burkhard 
Published: June 2022

ZUSAMMENFASSUNG
Die Liste der Malariaerreger, die den Menschen befallen können, umfasst nach klassischer Lehre Plasmodium (Pl.) falciparum, Pl. vivax, Pl. ovale und Pl. malariae; seit einigen Jahren ist Pl. knowlesi hinzugetreten. Von besonderem Interesse ist wegen der gravierenden klinischen Konsequenzen vor allem die Malaria tropica durch Pl. falciparum. Gegen diese richtet sich in der Reisemedizin auch die medikamentöse Malariaprophylaxe. Die anderen Parasiten gelten als selten und zumeist beherrschbar. Die WHO etwa vereinfacht im Weltmalariabericht 2021 {1] die Situation so sehr, dass sie überhaupt nur von „allen Malariafällen“ und einem Prozentsatz durch Pl. vivax spricht. Dieser Prozentsatz ist demnach von rund 8 % vor 20 Jahren auf nur noch 1,9 % im Jahr 2020 zurückgegangen. „Fälle“ impliziert dabei Erkrankte, die eine nachweisbare Parasitämie haben. Behandlungsziel ist dann die Entfernung der im Blut zirkulierenden Parasiten.
Patients with Somatic and Comorbid Mental Disorders have Similar
Psychological Capacity Impairment Profiles like Patients with Mental
Disorders
Authors: Muschalla Beate , Jöbges Michael 
Published: June 2022

Abstract
Objectives In patients with somatic illness and additional mental
disorder, not only motor or sensory functions may be impaired, but also
psychological capacities. These become more and more important for work ability
in our modern working world. There are presently no data about the type and
distribution of psychological capacity impairments in patients with comorbid
somatic and mental disorders. These data are however important for estimation of
diagnostic and therapy requirements.
Methods 402 orthopedic, cardiological, and neurological patients with
additional mental disorders were investigated with a structured clinical
assessment for mental disorders (MINI) and psychological capacity impairments
(Mini-ICF-APP).
Results In all three somatic indications at least half of the comorbid
patients had any clinically relevant psychological capacity impairment.
Neurological patients (67%) and orthopedic patients (72%) were
more often affected than cardiological patients (50.5%). Orthopedic
patients are slightly more impaired in self-care; neurological and orthopedic
patients are more impaired in mobility; and cardiological patients are less
impaired in assertiveness.
Conclusion In comparison of all three somatic patient groups with mental
disorders the number of psychological capacity impairments is similar. In
contrast to patients with mental disorders only (i. e. those without
somatic comorbidity), the psychological impairment quality in comorbid patients
may be influenced by the somatic illness. The data from this study are important
in order to estimate diagnostic and therapeutic needs, such as capacity training
or compensation of psychological capacity impairments.
Effect of intensified training on cognitive function, psychological state & performance in trained cyclists
Authors: Costello Sarah E. , Rossiter Jack R. W. , Howatson Glyn , Bell Phillip G. , O'Neill Barry V. , van Someren Ken , Haskell‐Ramsay Crystal F. 
Published: June 2022

ABSTRACTAthletes often undertake intensified training loads prior to competition with the goal of functionally overreaching for temporary performance enhancement; however, little is known about the impact of this on cognitive function. The aim of this study was to investigate the effect of intensified training induced fatigue on cognitive function, psychological state and performance in trained cyclists. Twenty‐three trained male cyclists were randomly assigned to an intensified training group or a control group for two‐weeks, followed by a two‐week taper period. At baseline, one‐week, two‐weeks and post‐taper, participants undertook a series of cognitive, performance, mood and recovery‐stress assessments. The training intervention significantly increased training volume, load and strain by 108%, 116% and 151% respectively. Peak and mean power output on a maximal test and time trial significantly decreased by 4.8% and 9.4% following the two‐week training intervention compared to baseline, in addition to a 169% change in total mood disturbance and significant disruption to recovery‐stress balance. No change in any cognitive measure was observed across the study period. Following a two‐week taper, performance, mood and well‐being measures returned to baseline. Two weeks of intensified training resulted in overreaching as identified by performance and psychological measures. Cognitive function was not sensitive to intensified training promoting caution with its use as a measure for the early identification of overreaching.
Theory and applications of integral transform: analytical and numerical study of nonlinear partial differential equations
Authors: Hussain Arshad , Saifullah Sayed , Ali Amir 
Published: June 2022

Abstract
This article discusses theory, properties, and applications of the novel integral transform known as

J

-transform (

J

T) for fractional differential equations. Several fundamental theorems on fractional Riemann-Liouville and Caputo derivatives as well as proofs of some important results and functions are presented using the proposed transform. The exact and approximate solutions to numerous fractional differential equations (nonlinear Whitham- Broer-Kaup and KdV equations) are presented with numerical illustrations for validity, accuracy, and efficiency. It is observed that this fast-converging transform is a functional and valuable method to study a wide range of nonlinear problems in science and engineering.
Towards a unified interpretation of the early Universe in R
2-corrected dark energy model of F(R) gravity*
Authors: Chen Hua , Katsuragawa Taishi , Matsuzaki Shinya 
Published: June 2022

Abstract

-corrected dark energy (DE) models in

gravity have been widely investigated in recent years, which not only removes the weak singularity potentially present in DE models but also provide us with a unified picture of the cosmic history, including the inflationary and DE epochs. Towards the unified interpretation of dynamical DE all over the cosmic history in the class of

-corrected DE models, we explore the universal features of the scalaron dynamics in the radiation-dominated epoch, along with the chameleon mechanism, by keeping our eyes on the inflationary and DE epochs. We show that the scalaron evolution does not follow a surfing solution and is mostly adiabatic before big bang nucleosynthesis (BBN), even properly including the kick by the nonperturbative QCD phase transition, hence a catastrophic consequence claimed in the literature is not applied to this class of DE models. This is due to the presence of the gigantic scale hierarchy between

correction and DE, so is the universal feature for the class of

-corrected DE models. The prospects for the post- or onset-inflationary epoch would be pretty different from what the standard

inflationary scenario undergoes due to the presence of the chameleon mechanism.
Low-frequency, low-intensity ultrasound modulates light responsiveness of mouse retinal ganglion cells
Authors: Zhuo Shun-Yi , Li Guo-Feng , Gong Hai-qing , Qiu Wei-Bao , Zheng Hai-Rong , Liang Pei-Ji 
Published: June 2022

Abstract

Objective. Ultrasound modulates the firing activity of retinal ganglion cells (RGCs), but the effects of lower-frequency, lower-intensity ultrasound on RGCs and underlying mechanism(s) remain poorly understood. This study aims to address these questions. Approach. Multi-electrode recordings were used in this study to record the firing sequences of RGCs in isolated mouse retinas. RGCs’ background firing activities as well as their light responses were recorded with or without ultrasound stimulation. Cross-correlation analyses were performed to investigate the possible cellular/circuitry mechanism(s) underlying ultrasound modulation. Main results. It was found that ultrasound stimulation of isolated mouse retina enhanced the background activity of ON-RGCs and OFF-RGCs. In addition, background ultrasound stimulation shortened the light response latency of both ON-RGCs and OFF-RGCs, while enhancing part of the RGCs’ (both ON- and OFF-subtypes) light response and decreasing that of the others. In some ON-OFF RGCs, the ON- and OFF-responses of an individual cell were oppositely modulated by the ultrasound stimulation, which suggests that ultrasound stimulation does not necessarily exert its effect directly on RGCs, but rather via its influence on other type(s) of cells. By analyzing the cross-correlation between the firing sequences of RGC pairs, it was found that concerted activity occurred during ultrasound stimulation differed from that occurred during light stimulation, in both spatial and temporal aspects. These results suggest that the cellular circuits involved in ultrasound- and light-induced concerted activities are different and glial cells may be involved in the circuit in response to ultrasound. Significance. These findings demonstrate that ultrasound affects neuronal background activity and light responsiveness, which are critical for visual information processing. These results may also imply a hitherto unrecognized role of glial cell activation in the bidirectional modulation effects of RGCs and may be critical for the nervous system.
Anthropogenic aerosol impacts on Pacific Coast precipitation in CMIP6 models
Authors: Allen Robert J , Zhao Xueying 
Published: June 2022

Abstract
Studies show anthropogenic aerosols (AAs) can perturb regional precipitation, including the tropical rain belt and monsoons of the Northern Hemisphere (NH). In the NH mid-latitudes, however, the impact of AAs on regional climate and precipitation remains uncertain. This work investigates the influence of AAs on wintertime precipitation along the North American Pacific Coast using models from the Coupled Model Intercomparison Project phase 6 (CMIP6). Over the early to mid-20th century, when U.S. and European AA and precursor gas emissions rapidly increased, a robust wintertime precipitation dipole pattern exists in CMIP6 all-forcing and AA-only forcing simulations, with wetting of the southern Pacific Coast (southward of ∼40∘ N) and drying to the north. A corresponding dynamical dipole pattern also occurs—including strengthening of the east Pacific jet southward of ∼40∘ N and weakening to the north—which is related to a Rossby wave teleconnection that emanates out of the tropical Pacific. Over the 21st century, when AAs are projected to decrease, an opposite hydro-dynamic dipole pattern occurs, including drying southward of 40∘ N (including California) and wetting to the north. Although Pacific Coast precipitation is dominated by natural variability, good multi-model agreement in the forced component of Pacific Coast precipitation change exists, with the AA pattern (north south dipole) dominating the greenhouse gas (uniform) pattern in the historical all-forcing simulations. A high level of agreement in individual model-realization trends also exists, particularly for the early part of the 20th century, suggesting a robustness to the human signature on Pacific Coast precipitation changes. Thus, historical precipitation responses along the Pacific Coast are likely to have been driven by a mixture of natural variability and forced changes. Natural variations appear to drive a large fraction of this change, but human influences (i.e. aerosols) are likely to have preconditioned the variability of the climate in this region.
Tribunal secretaries re-examined—comparative legal framework, best practices, and terms of appointment
Authors: Schroeder Hans-Patrick , Junge Wolfgang 
Published: June 2022

Abstract
The tribunal secretary has had a short but stellar career so far. Within 20 years of first being recognized as a wide-spread and potentially problematic phenomenon in international arbitration, it has since been the object of decisions in various jurisdictions, institutional rules, and extensive academic analysis. The authors aim to sort through the different views in an effort to suggest best practices and model terms of appointment.
mapDATAge: a ShinyR package to chart ancient DNA data through space and time
Authors: Liu Xuexue , Orlando Ludovic 
Published: June 2022

AbstractSummaryAncient DNA datasets are increasingly difficult to visualize for users lacking computational experience. Here, we describe mapDATAge, which aims to provide user-friendly automated modules for the interactive mapping of allele, haplogroup and/or ancestry distributions through space and time. mapDATAge enhances collaborative data sharing while assisting the assessment and reporting of spatiotemporal patterns of genetic changes.Availability and implementationmapDATAge is a Shiny R application designed for exploring spatiotemporal patterns in ancient DNA data through a graphical user interface. It is freely available under GNU Public License in Github: https://github.com/xuefenfei712/mapDATAge.Supplementary informationSupplementary data are available at Bioinformatics online.
microbiomeMarker: an R/Bioconductor package for microbiome marker identification and visualization
Authors: Cao Yang , Dong Qingyang , Wang Dan , Zhang Pengcheng , Liu Ying , Niu Chao 
Published: June 2022

AbstractSummaryCharacterizing biomarkers based on microbiome profiles has great potential for translational medicine and precision medicine. Here, we present microbiomeMarker, an R/Bioconductor package implementing commonly used normalization and differential analysis (DA) methods, and three supervised learning models to identify microbiome markers. microbiomeMarker also allows comparison of different methods of DA and confounder analysis. It uses standardized input and output formats, which renders it highly scalable and extensible, and allows it to seamlessly interface with other microbiome packages and tools. In addition, the package provides a set of functions to visualize and interpret the identified microbiome markers.Availability and implementationmicrobiomeMarker is freely available from Bioconductor (https://www.bioconductor.org/packages/microbiomeMarker). Source code is available and maintained at GitHub (https://github.com/yiluheihei/microbiomeMarker).Supplementary informationSupplementary data are available at Bioinformatics online.
No Knowledge of ‘Public Funds’? An Investigation into Social Work Practitioners’ Confidence and Knowledge When Working with Adults with ‘No Recourse to Public Funds’
Authors: Hines Zoë , Leishman Eppie 
Published: June 2022

Abstract
Literature suggests health and social care professionals lack the knowledge and confidence required to work effectively with those subject to immigration control. However, thus far few studies have focused on the social work profession. Using quantitative methods, this study explored social work practitioners’ knowledge and confidence of the entitlements of adults with ‘no recourse to public funds’ (NRPF) to adult social care services, through an anonymous, online, national survey (n = 113). Using statistical tests for parametric data, several significant results were found. Training attendance had a statistically significant relationship with knowledge and confidence. Seniority level, years of experience and number of adults with NRPF worked with had statistically significant relationships with confidence but not knowledge. Findings suggest that respondents had adequate knowledge of Care Act assessments. However, confidence was low and knowledge was poor around the entitlements of asylum seekers specifically, access to advocacy and use of human rights assessments. Hence, it is suggested that social work employers should prioritise training on NRPF entitlements, focusing on the areas of poor knowledge found in this study. Moreover, further research with adults with NRPF is needed to better understand their experiences of accessing adult social care.
Media power and politics in framing and discourse theory
Authors: Roslyng Mette Marie , Dindler Camilla 
Published: June 2022

AbstractTwo widely applied entrances to critically analyze mediated political communication are framing and discourse theory. While media discourse and framing are used in close connection in academic literature, we examine how the approaches theorize media power and politics differently. Framing theory examines how issues are constructed interactively, represented in mediated form, and interpreted within an institutionalized policy sphere. Some framing studies critically examine structural or hegemonic power. However, the preoccupation with manifest interactions entails a diminished sensibility to systematic exclusion. Discourse theory provides a post-foundational conceptualization of politics as the political in which media discourses are antagonistic, contingent, and open to change. Discourse theory expands media power to include (subversive) positions beyond hegemonic politics. We argue that applying either discourse or framing theory in media studies has theoretical and analytical consequences and that theoretical sensitivity will strengthen the discriminatory power of framing and discourse theory as two distinct fields.