bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cutaneous Manifestations of Novel Coronavirus Disease (COVID-19):
A Case with Staphylococcal Scalded Skin Syndrome (SSSS)
Authors: Jafari Maedeh , Hosseininasab Ali , Sinaei Reza , Ebrahimi Sarehossadat , Parvaresh Saeedeh 
Published: April 2022

Background:
The coronavirus disease 2019 (COVID‐19) was first reported in December 2019 in Wuhan, China. Skin manifestations of COVID-19 have been reported sporadically. Staphy-lococcus aureus occurs after viral infection due to unregulated IFN-α. We designed this reported case to pay more attention to the rare skin manifestations following COVID-19.

Case Report:
The patient was a 12-month-old girl who presented with fever and skin rashes. Two days before admission, erythematous rashes spread around the mouth, nose, eyes, and trunk. Ery-thematous lesions begin to peel the next day. RT-PCR of the nasopharynx was positive for COVID-19. Treatment with vancomycin and clindamycin was started. The patient was discharged with complete recovery of skin lesions.

Conclusion:
One of the early manifestations of COVID-19 in children can be fever and rash. Clini-cal suspicion led to more attention to complications of bacterial superinfection such as staphylococ-cal scalded skin syndrome.
Assessment of the Effect of Timing of Insulin Glargine Administration
(Bedtime versus Morning) on Glycemic Control in Children with Type 1
Diabetes in Cairo, Egypt: A Single Centre Experience
Authors: Abdou Marise , Shamma Radwa A. , Anwar Ghada M. , Musa Noha , Mira Marwa F. 
Published: April 2022

Background:
Diabetes control without developing hypoglycemia is challenging in Type
1 diabetes (T1D) management, with few studies evaluating the effect of insulin glargine timing on
glucoregulation.

Objectives:
The aim is to compare glycemic control using continuous glucose monitoring (CGM)
in children with T1D receiving bedtime versus morning glargine and to assess CGM effect on glycemia.

Methods:
This cross-sectional observational study was conducted on 30 pediatric patients with
T1D receiving glargine (19 at bedtime and 11 in the morning). CGM sensor was applied for 3-5
days using the I-Pro2 blood glucose sensor.

Results:
Total daily dose of glargine showed a significant correlation with HbA1C (p=0.006) and
percentage of glucose readings within average (p=0.039). HbA1C correlated significantly with
time in range (TIR) (p=0.049). Nocturnal hypoglycemia was significantly higher in the bedtime
glargine group than in the morning one (p=0.016). The morning glargine group showed better control
in terms of lower HbA1C and higher TIR, but these did not reach statistical significance. Follow-
up after 3 months revealed significant improvement in the percentage of hyperglycemia, BG
readings within average, as well as HbA1c (p:0.001).

Conclusions:
Bedtime glargine administration was associated with a higher frequency of occurrence
of nocturnal hypoglycemia. No statistically significant difference in glycemic control between
both groups was found. CGM use improved glycemic control.
Clinical and Imaging Features of Desmoplastic Fibroma of Bone for
Correct Diagnosis and Differentiation
Authors: Zhong Zhi-Wei , Wu Wen-Juan , Zhang Zu-zhuo , Cao Lei , Guo Zhe , Wu Hui-Zhao , Gao Bu-Lang 
Published: April 2022

Objective:
The objective of this study is to analyze the clinical and imaging features of
desmoplastic fibroma of bone (DFB) for correct diagnosis.

Materials and methods:
Twenty patients with DFB confirmed by pathology were enrolled, and the
imaging presentations were analyzed. Among 20 patients, plain X-ray was performed in all patients,
computed tomography (CT) was performed in 12, and magnetic resonance imaging (MRI) was conducted
on eight. The clinical and imaging presentations were analyzed and classified to assist in correct
diagnosis.

Results:
Twenty patients with DFB were retrieved, including eleven males and nine females with an
age range of 2-52 years (median 27). The DFB involved the femur in six patients, ilium in five, tibia in
four, humerus in two, lumbar vertebra in one, radius in one, and calcaneus in the remaining one. DFB
was common in the metaphysis of long bones and could involve the diaphysis and epiphysis. The imaging
presentations were divided into four types: the cystic expansile destruction in ten patients, osteolytic
destruction in five, mixed destruction in four, and paraosseous destruction in one. CT value was 30 -60
Hu in the lesion area (6 cases CT value＞45Hu). In eight patients with MRI scanning, the lesion in five
patients presented with unevenly equal or low signal on T1WI and unevenly equal or high signal on
T2WI, with irregular stripes or patches of low signal on both T1WI and T2WI. In the rest three patients,
the lesion was evenly equal or low signal on T1WI and evenly high signal on T2WI. MRI more clearly
showed a mass in the adjacent soft tissue and the range of edema in the DFB lesion.

Conclusion:
DFB is a rare tumor with strong local aggressiveness, cystic bone destruction, formation of
tumor bone trabeculae, soft tissue masses on imaging presentations, low signals on T1WI and T2WI in
the lesion, but no periosteal reaction or calcification, which are helpful for diagnosis of the disease and
differentiation from other ones.
Natural Anti-inflammatory and Anti-allergy Agents: Herbs and Botanical Ingredients
Authors: Saini Rashmi , Dhiman Neena K. 
Published: April 2022

Abstract:Allergies have been known to be an abnormally vigorous immune response in which the immune system fights off an allergen or antigen, initiating mast cells to release histamine into the blood. Substances that prevent mast cells from releasing histamine are considered antiallergic agents. The drugs utilized to treat allergy are mast cell stabilizers, steroids, anti-histamine, leukotriene receptor antagonists, and decongestants. Anti-histamine drugs have side effects such as drowsiness, confusion, constipation, difficulty urinating, blurred vision, etc. The use of medicinal plants for the effective and safe management of diseases has recently received much attention. Various herbs are utilized for their antiallergic and anti-histaminic properties. Some of the herbs useful in the management of allergic diseases of the respiratory tract, like Piper longum, Ocimum tenuiflorum, Solanum xanthocarpum have been discussed. Ample scientific evidence is available for the anti-histaminic and antiallergic activity of Azadirachta indica, Aloe vera, Tinospora cordifolia, and many other such herbs are safer to use as antiallergic agents have been reported. The review summarizes a wide variety of herbs and botanical ingredients with their common scientific names and distribution for easy identification and usage as safe antiallergic agents and discusses their molecular mechanisms involved in combating allergic reactions.
Application of Watermarking Technology based on Deep Learning in Face
Recognition
Authors: Wang Dehui , Liu Jinfu , Zhang Yingqian , Zhang Nian , Wang Xingyuan 
Published: April 2022

Background:
Face recognition which belongs to biometric recognition has great application value. Nowadays, face recognition based on deep learning has been widely used in many fields such as internet payment, network login and authentication. However, the face recognition deep learning model are easily replaced and tampered with. Once the models are illegally attacked, it will infringe the intellectual property rights of the model owner and cause economic losses. To deal with these threats, we use watermarking technology to add identity into the face recognition deep learning model. When it is replaced or tampered with, we can prove that the model belongs to us by extracting the watermarks.

Objective:
In this study, our innovate framework is designed to add watermarks into the face recognition deep learning model as identity, which makes it have features of both trigger sets and data sets. The model will be robust enough to resist common machine learning attacks. With special watermarks, its ownership can be guaranteed.

Method:
We construct a special watermark trigger set and embed it into the model, which makes it trained without human intervention and annotation. To be flexible for a variety of applications, this scheme uses chaotic sequences to label a watermark trigger set, which guarantees the non-generalization of the watermark. The initial value and parameters used in the method are designed respectively as key to the model. We train 4 models with different number of trigger samples, which is used to study the effect of the number of trigger samples on the model accuracy.

Results:
We successfully propose a watermarking method for adding identity to the face recognition deep learning model. Watermark extraction rate of the proposed framework is 100%, which means our method can successfully prove ownership of the face recognition deep learning model. In destructive experiments, Models subject to fine-tuning attack still have high face recognition rates which are over 99.00%, and extraction rates of watermarks of each model is 100%. Under overwriting attack, the extraction rates of watermarks of models are less than 25%, models cannot maintain the original performance, which means that watermarks can provide protection until the model loses its ability. The experimental results indicate that the proposed scheme is robust against common machine learning attacks and it prevent the model from being replaced and tempering with.

Conclusion:
The robustness of the proposed method is capable of resisting machine learning attacks and fine-tuning attacks. It also provides good fidelity, safety, practicality, completeness and effectiveness. With the help of special watermarks, related departments can effectively manage face recognition deep learning models. Besides, it can facilitate the commercialization of intelligent models.
Enamel Hypoplasia as a Marker for Sex Estimation: A Review
Authors: Caldas Inês Morais , Madureira-Carvalho Áurea , Pereira Maria Lurdes 
Published: April 2022

Abstract:
Changes in enamel during teeth development are permanently recorded, and some, like
enamel hypoplasia (EH), can be linked with stressful events. As males and females may respond
differently to stress, EH may have a different prevalence between the sexes. The present work
mainly aims to identify which factors may lead to the different EH types, analyse how they manifest
between sexes, and check if, in the presence of EH, one can infer about a person’s sex. Our
results point to occasional differences in EH prevalence in deciduous dentition between sexes, with
males displaying more EH. As for permanent dentition, EH prevalence appears to be strongly associated
with the living conditions, namely nutrition, occluding any possible sex bias. Therefore,
EH in deciduous teeth can be useful for sex estimation; yet, in permanent dentition, other factors
may be responsible for the differences and more studies, with control of environmental factors (for
example, twin studies) are needed to understand if sex differences exist as well.
An Overview of Biological Importance, Pharmacological Aspects, and
Analytical Techniques of Bavachin from Psoralea corylifolia Linn.
Authors: Patel Dinesh Kumar 
Published: April 2022

Background:
Psoralea corylifolia Linn belongs to Leguminosae family is commonly known as ‘Bakuchi’ in Ayurvedic system of medicine. P. corylifolia is an important medicinal herb used for the treatment of Leucoderma, psoriasis and leprosy. P. corylifolia seed contain psoralen, psoralidin, isopsoralen, neobavaisoflavone, corylin, bavachin, and bavachalcone. P. corylifolia has been used for the treatment of asthma, vitiligo, nephritis, calvities and cough. Bavachin is a pure phytochemical, found to be present in the seeds and fruit of P. corylifolia.

Methods:
In order to know the medicinal properties and therapeutic benefit of bavachin in the medicine, numerous scientific research data have been collected from different literature sources and analyzed. Medicinal importance and pharmacological activities of bavachin has been investigated through literature data analysis of different scientific research works. Scientific research data has been collected from databases such as PubMed, Google, Google Scholar, Science Direct, and Scopus using words Psoralea corylifolia and bavachin. Further maximum scientific article of bavachin with respect to its pharmacological activities, medicinal importance, and analytical data of has been collected from these databases and presented here with proper citation.

Results:
Data analysis of scientific research works of bavachin revealed the biological importance of bavachin in the medicine. Bavachin showed anti-inﬂammatory, anticancer, anti-bacterial, lipid-lowering and cholesterol-reducing properties in the medicine. Bavachin has multiple pharmacological activities including platelet aggregation, α-glucosidase activities and antibacterial potential. Bavachin has a potential estrogen supplement for estrogen replacement therapy. Present work summarized biological potential of bavachin on inflammatory disorders, articular cartilage degeneration, cardiovascular disease, hyperglycemia, Parkinson's disease, Alzheimer's disease, apoptosis, melanin synthesis, estrogen Receptor, UDP-glucuronosyltransferase 1A1 and various form of pathogenic infection. Analytical data revealed the significance of an HPLC-UV, HPLC, HPLC-ECD, HPLC-DAD, IT-MS, HPLC, HPLC/TOF-MS, LC-MS/MS and ILUAE techniques for separation, identification and quantification of bavachin in different samples.

Conclusion:
Literature data analysis revealed the biological importance and therapeutic potential of bavachin in the medicine for the treatment of various form of human disorders.
STATE OF PROOXIDANT AND ANTIOXIDANT BLOOD SYSTEMS IN WHITE RATS WITH EXPERIMENTAL DIABETES MELLITUS
Authors: Zaiats L. M. , Fedorchenko Yu. V. 
Published: April 2022

Резюме. Мета: вивчити стан прооксидантно-антиоксидантної систем крові у білих щурів при експериментальному цукровому діабеті.
Матеріали і методи. Модель цукрового діабету відтворювали шляхом внутрішньоочеревинного введення білим щурам стрептозотоцину фірми «Sigma» (США), розведеного в 0,1 М цитратному буфері з рН 4,5, з розрахунку 60 мг/кг маси тіла. Контрольній групі тварин внутрішньоочеревинно вводили еквівалентну дозу 0,1 М цитратного буферного розчину з рН 4,5. У сироватці крові визначали вміст дієнових кон’югатів, активність каталази через 14, 28, 42 і 70 діб після ін’єкції стрептозотоцину.
Результати. Біохімічні дослідження сироватки крові показали, що у тварин з цукровим діабетом спостерігається підвищення рівня дієнових кон’югатів на всіх етапах експерименту: через 14 діб на 31,8%, через 28 діб на 104,4%, через 42 доби на 112,5% і через 70 діб на 125,4%. Водночас у сироватці зростала активність каталази. Зокрема через 14 діб концентрація даного ензиму була підвищена на 46,6 %, через 28 діб на 74,8%, через 42 доби – на 29,3%. Через 70 діб дослідження відмічалося зменшення активності каталази на 28,1% у порівнянні з показником контрольної групи тварин.
Висновки. Експериментальний цукровий діабет протягом усього періоду дослідження супроводжується інтенсифікацією процесів ліпопероксидації, що проявляється достовірним підвищенням у сироватці крові вмісту дієнових кон’югатів. На тлі розвитку цукрового діабету у сироватці крові відмічається виснаження ферментної ланки антиоксидантної системи, про що свідчить зменшення каталазної активності, яка особливо виражена на 70-у добу експерименту.

Ключові слова: стрептозотоцин-індукований діабет, дієнові кон’югати, каталаза.
The Impact of Health Care Funding on Interprofessional Collaboration and Integrated Service Delivery in Primary and Allied Care: Protocol for a Scoping Review
Authors: Archer Jessica , Robinson Luke , Brown Ted 
Published: April 2022

Background
Improving funding models and implementing policies that facilitate greater interprofessional collaboration and integration at the primary and allied health level could improve the ongoing quality and safety and future sustainability of the wider health care system by reducing inefficiencies and inequalities. Defining these key health care funding–related models, policies, and concepts, identifying research gaps, and systematically mapping the associated literature will inform future research on this topic.

Objective
The aim of this scoping review is to provide a descriptive overview of contemporary health care funding models and the key policies involved in the delivery of primary and allied health care. Further, it will investigate the impact these models and policies have on interprofessional collaboration and integrated service delivery at the primary and allied health care levels.

Methods
A search of published and grey literature will be conducted using the following databases: the Allied and Complementary Medicine Database, CINAHL, Embase, Emcare, MEDLINE, PsycINFO, Scopus, Open Access Theses and Dissertations, and Web of Science. The search will be limited to resources available in the English language and published since 2011. Following the search, an independent screening of titles and abstracts will be undertaken by 2 independent reviewers, with a third reviewer available to resolve any potential disagreements. Full-text resources will then be assessed against the inclusion criteria following the same process. Extracted data will be presented using a convergent narrative approach, accompanied by tables and figures.

Results
Electronic database searches have retrieved 8013 articles. The results of this scoping review are expected in May 2022.

Conclusions
The findings from this review will be used to inform future research projects investigating the role of primary health care funding, interprofessional collaboration, and service integration in improving health care access, efficiency, effectiveness, and sustainability.

International Registered Report Identifier (IRRID)
DERR1-10.2196/36448
Analisis Unsur Intrinsik Dan Nilai Pendidikan Karakter Dalam Geguritan Ginal-Ginul
Authors: Sumerta Gede Budi , Ludy Paryatna Ida Bagus Made , Purnami Ida Ayu Putu 
Published: April 2022

Penelitian ini bertujuan untuk menjelaskan dan menunjukkan keberadaan unsur intrinsik dan nilai pendidikan karakter dalam geguritan Ginal-Ginul. Penelitian ini menggunakan metode penelitian deskriptif kualitatif. Subjek penelitian ini adalah geguritan Ginal-Ginul. Objek dari penelitian ini adalah unsur intrinsik dan nilai pendidikan karakter yang terdapat dalam geguritan Ginal-Ginul. Metode pengumpulan data dilaksanakan dengan studi dokumentasi. Intrumen pengumpulan data menggunakan kartu data. Analisis data dimulai dari reduksi data, pemaparan data, menyimpulkan dan verifikasi. Data mengenai unsur intrinsik diperoleh berupa terdapat 12 tokoh cerita yang dibagi menjadi dua jenis tokoh yaitu tokoh utama dan tokoh tambahan; masing-masing tokoh memiliki penokohan yang berbeda; ada tiga jenis latar yang ditemukan yaitu latar tempat, waktu dan suasana; alur yang digunakan berupa alur lurus (progresif); gaya bahasa utamanya paribasa yang ada berupa sesawangan, pepindan, sesonggan dan sesimbing; Sudut pandang yang digunakan adalah sudut pandang pengarang sebagai pengarang serba tahu; amanatnya adalah diharapkan generasi muda berperilaku sesuai dengan nilai pendidikan karakter; Tema geguritan ini adalah ilmu pengetahuan. Data mengenai nilai pendidikan karakter diperoleh berupa nilai ketekunan; nilai kejujuran; nilai keberanian; nilai kepedulian; nilai disiplin; nilai kewarganegaraan; nilai rasa hormat; nilai tanggung jawab.Kata Kunci: Unsur Intrinsik, Nilai Karakter, Geguritan
Emigration of Russian doctors abroad: reasons and potential of reemigration
Authors: Grebenyuk A. A. , Krasnikova E. S. 
Published: April 2022

The article presents the results of an empirical study. The aim of the study is to identify the real factors of the emigration of Russian doctors abroad in the period from 2013 to 2019. The theoretical part of the study was built within the framework of a sociological approach. The theory of “attraction and pushing” by Everett Lee was taken as a basis. In the course of the study, 10 in-depth interviews were conducted with Russian doctors who at the time of the study were permanently living and working abroad. The uniqueness of the results of this study lies in the fact that the empirical object of the study is not doctors who want to go abroad, but doctors who have already moved and at the time of the study are permanently residing abroad. In each interview, questions were asked on the following topics: reasons for moving from Russia, how was the decision-making process to move, how the respondent chose a country for a new place of residence, what were the costs of moving, the respondent’s attitude to the Russian healthcare system, the question of returning to Russia.The article is divided into two parts. The ﬁrst part provides a detailed analysis of the research results with quotes from respondents. The second part describes 4 groups of identiﬁed factors of emigration of Russian doctors: pull factors abroad in general, pull factors in the healthcare system abroad, push factors in Russia as a whole, push factors in the healthcare system in Russia. According to the results of the study, it was revealed that the push factors of the emigration of Russian doctors abroad over the attractive ones. Extremely low return migration attitudes have been identiﬁed. Also, no signiﬁcant impact of socio-political and natural-climatic factors of pushing out on the process of emigration of Russian doctors was revealed.
flexibilização da confidencialidade nas reproduções humanas assistidas frente ao direito fundamental à identidade genética
Authors: Klitche Vinícius Daniel , Favero Sabrina 
Published: April 2022

O estudo analisa a possibilidade de flexibilização do anonimato do(a) doador(a) nas reproduções humanas assistidas heterólogas frente ao direito à identidade genética. A confidencialidade do(a) doador(a) é fundamental nessa forma de reprodução, cuja utilização tem se popularizado nos últimos tempos. Há, entretanto, controvérsia se esse anonimato pode ser mitigado, sobretudo quando confrontado com o direito fundamental à identidade genética. No Brasil, embora não exista legislação especifica sobre o assunto, há diversos projetos de lei em trâmite no Congresso com o escopo de regulamentar o tema. A proteção do anonimato está assentada em critério utilitarista e na sobreposição da socioafetividade, ao passo que a mitigação tutela o direito do indivíduo em conhecer sua origem biológica. A conclusão é que existe uma tendência legal, doutrinária e jurisprudencial em admitir a flexibilização quando em conflito com o direito à identidade genética. A pesquisa foi desenvolvida em três tópicos: no primeiro, analisou-se a reprodução humana assistida como um produto dos avanços tecnológicos, sociais e jurídicos; no segundo, discorreu-se sobre o direito fundamental à identidade genética e se seu conhecimento gera algum vínculo filiatório; e, por fim, analisou-se algumas situações em que o rompimento do anonimato se mostra necessário, bem como os argumentos contrários à flexibilização. A pesquisa é qualitativa teórica, amparada por literatura especializada, com análise da legislação atinente ao tema, tendo sido utilizado o método dedutivo.