bluuebunny/crossref_metadata_2025_split huggingface dataset:
Application of Ensemble Sensitivity for Hurricane Track Forecast Sensitivity and Flight Planning
Authors: Torn Ryan D. , Brennan Michael J. , Dunion Jason P. 
Published: February 2025

Abstract
The forecast motion of tropical cyclones (TCs) critically depends on the evolution of the layer-average steering flow, which is associated with features proximate and remote to the TC. Given this, it is of interest to objectively identify locations and aspects of the steering flow that will have the biggest impact on subsequent TC track forecasts, which in turn could be used to identify where to take supplemental observations, such as from aircraft, or extra rawinsondes. This paper describes the application of the ensemble-based sensitivity method to evaluate the sensitivity of TC track forecasts, which was used for synoptic surveillance flight planning for 55 potential missions during the 2019-2021 seasons. TC track sensitivity can be calculated from either operational ECMWF and GEFS ensemble output (following the GEFS upgrade to version 12). Several automated methods are developed and described that provide sensitivity guidance that is useful and can be quickly interpreted, including a time-integrated track metric, and defining the steering wind within a coordinate framework along the axis of greatest position variability, or vorticity. For the majority of cases, the sensitivity to the steering wind is maximized within 500 km of the TC center, particularly in the vicinity of nearby weaknesses in the subtropical ridge, with comparatively less sensitivity to upstream midlatitude features.
Frosted branch angiitis post COVID vaccine: A presumptive association with Behçet's disease
Authors: Alegre-Ituarte Victor , Bodaghi Bahram , Touhami Sara 
Published: February 2025

Purpose To report a case highlighting the uncommon presentation of Frosted Branch Angiitis (FBA) in Behçet's Disease (BD), notably in a patient who received a COVID vaccine one month prior to the onset of symptoms. We explore the possible role of vaccination in unmasking BD. Methods A comprehensive evaluation of a 45-year-old patient with FBA post-COVID vaccination was undertaken. Results The patient exhibited characteristic features of FBA, with classic perivascular sheathing, optic disc edema, and retinal ischemia, which manifested one month after receiving the Pfizer/BioNTech COVID vaccine. Despite a history of recurrent oral aphthosis, systemic workup for autoimmune conditions was unremarkable. Diagnosis of presumptive Behçet's Disease was made based on clinical criteria. Treatment with intravenous methylprednisolone and infliximabn (5 mg/kg) led to complete resolution of ocular symptoms and retinal signs. Conclusion FBA is an uncommon presentation of BD. This case also serves as a stark reminder of the potential consequences of vaccination on immune-mediated diseases. However, the correlation between FBA onset, COVID vaccination, and Behçet's Disease diagnosis necessitates cautious interpretation. Successful use of methylprednisolone and infliximab in achieving resolution of visual symptoms highlights potential therapeutic considerations in similar cases.
Endovascular Therapy for Large Ischemic Stroke in Directly Admitted vs Transferred Patients - A Secondary Analysis
Authors: Li Man , Zheng Lina , Nie Ximing , Wang Mengxing , Liu Xin , Duan Wanying , zhang zhe , Wen Miao , yang zhonghua , Huo Xiaochuan , Leng Xinyi , Pan Yuesong , Nguyen Thanh N , Miao Zhongrong , Liu Liping 
Published: February 2025

BACKGROUND: Endovascular therapy (EVT) has been proved to benefit patients with acute large vessel occlusion (LVO) with large infarcts, but it is unknown whether the benefit isaffected by the interhospital-transfer status. We investigated the efficacy of EVT according to the interhospital-transfer status in such patients. METHODS: This was a secondary analysis of the ANGEL-ASPECT trial. Patients with acute anterior-circulation LVO and large infarcts, defined by ASPECTS 3-5 or infarct core volume 70-100mL, were enrolled from forty-six centers across China and randomized (1:1) to receive EVT with medical management (MM) versus MM alone. We dichotomized patients into two subgroups based on whether admitted directly to the EVT-capable center or transferred from a primary center. The primary outcome was the 90-day modified Rankin Scale (mRS). RESULTS: From October 2020 to May 2022, 456 patients were recruited and one withdrew consent. 455 patients were included in this analysis, with 210 (46.2%) in the direct subgroup and 245 (53.8%) in the transfer subgroup. The transfer subgroup had longer median onset-to-arrival time than the direct patients (379 vs 279mins, p <0.001), while there was no significant difference in the arrival-to-recanalization time (197 vs 205 mins, p=0.087) between the two subgroups. A significant ordinal shift of 90-day mRS towards a better functional outcome in EVT than MM (generalized odds ratio [gOR], 1.67; 95% CI, 1.03-2.70, p=0.036 versus gOR, 1.60; 95% CI, 1.02-2.50, p=0.039) was found in the direct and transfer group, respectively. There was no significant interaction of the two subgroups over the treatment effect of EVT versus MM on the primary outcome (p for interaction=0.706). CONCLUSIONS: In acute anterior-circulation LVO patients with large infarcts, the benefit of EVT compared to MM did not vary by the interhospital-transfer status.
Biogenic pyrite and metastable iron sulfides: Emerging formation pathways and geological and societal relevance
Authors: Mansor Muammar , Duverger Arnaud , Pasquier Virgil , Gorlas Aurore , Guyot François , Berg Jasmine S. , Marin-Carbonne Johanna , Cosmidis Julie , Picard Aude 
Published: February 2025

Abstract
Iron sulfide (Fe-S) minerals such as mackinawite (FeS), greigite (Fe3S4) and pyrite (FeS2) are widespread on Earth, where their formation and dissolution are strongly linked to the biogeochemical cycles of iron, sulfur, carbon, oxygen, nutrients and trace metals. Recent studies have shed light on how microorganisms mediate their formation, with breakthroughs linked to biogenic pyrite. In this review, we highlight the formation pathways of Fe-S minerals, starting with the increasingly recognized roles of Fe(III) and intermediate sulfur species (e.g. S0 and polysulfides) during the initial steps. The mechanisms by which microorganisms affect Fe-S mineral formation are compiled and discussed for low (25–35°C) and high (≥ 80°C) temperatures, with specific examples from experimental studies. The morphology and precipitation rates obtained from experiments are compared to natural environments, and their similarities and differences are critically discussed. We then review the current state of the art for Fe-S minerals in the context of the origin of life and as environmental proxies and biosignatures in the geological record using their texture and chemical and isotopic compositions. We end by highlighting the importance of Fe-S minerals for current societal issues, such as the sequestration of organic carbon, the formation of acid drainages, metal recovery and nitrate removal, and their potential use as technological bio-materials in the future.
Predictors of storage lower urinary tract symptoms after bipolar transurethral resection of the prostate
Authors: Emam Ahmed , ElSaeed Karim 
Published: February 2025

Abstract

Background
Storage lower urinary tract symptoms (LUTS) are often experienced after transurethral resection of the prostate (TURP). The purpose of this study was to determine potential risk factors that could contribute to this condition.

Methods
This prospective study included 120 consecutive patients undergoing bipolar TURP. Patients undergoing other procedures besides TURP, such as cystolitholapaxy, diverticulectomy, and urethrotomy were excluded, as were patients with neurological diseases or active urinary tract infection (UTI). The standard preoperative evaluation was done routinely, including the International Prostate Symptom Score (IPSS) with its storage and voiding sub-scores, urine culture, and abdominopelvic ultrasonography with an assessment of postvoiding residual urine (PVRU). Possible preoperative, intraoperative, and postoperative variables that may lead to storage LUTS following bipolar TURP were recorded and analyzed.

Results
Of 120 patients included in our study, 52 (43.3%) patients experienced storage LUTS at 1 week after catheter removal following bipolar TURP. Of the tested variables, age (68.5 ± 6.0 vs 63.7 ± 5.4 years), higher preoperative irritative IPSS subscore (11.0 ± 2.3 vs 8.0 ± 2.7), smaller prostate size (55.3 ± 12.7 vs 61.0 ± 16.3 gm), gross vs fine hemostasis of prostatic fossa, shorter catheter duration (2.3 ± 0.8 vs 3.0 ± 0.9 days), and post-TURP UTI were found to be statistically significant in univariate analysis. Using backward multivariate logistic regression, after adjustment of significant factors in univariate analysis, it was shown that IPSS irritative subscore was an independent factor affecting storage LUTS post-TURP (OR = 1.525; CI  1.298–1.79, P < 0.001).

Conclusions
Variable prognostic factors were related to storage LUTS following TURP; however, preoperative IPSS irritative subscore was an independent factor associated with such a condition, which should be emphasized during preoperative patient counseling.
Can a novel set of handgrips on a walking frame increase stability and support users when transferring to/from a chair?
Authors: Thies Sibylle Brunhilde , Bevan Susan , Wassall Matthew , Mootien Cynthia Poolay , Kenney Laurence , Howard David 
Published: February 2025

Abstract

Introduction
One important aspect of walking aid use is transferring safely to the aid from sitting and transferring back to the chair after walking, since these activities have been associated with falls in older adults. Standard frames require their user to push off the chair or ask for help from a carer, which may over time lead to back pain. This study’s aim was to assess whether novel handgrips located above the rear feet of a walking frame would facilitate safe transfer as compared to utilizing only the seat cushion or armrests of the chair.

Methods
In a gait lab-based trial 10 healthy older adults repeatedly transferred from sitting to standing, pushing off the chair’s seat cushion, armrests, or using the new lower handles on the frame (alone or in combination with the seat cushion or armrest). The stability margin ‘SM’, defined as the distance between the centre of pressure and the nearest edge of the base of support for the user-device-chair system, was calculated as a mechanical measure of stability. Specifically, SM provides a measure of how close the system is to the point of tipping over. Additionally, 13 older frame users tried to use the new handgrips to transfer to/from the new frame and gave interviews which were thematically analysed.

Results
Stability for the 10 healthy older adults was statistically either equivalent or better when using one or both handles on the novel frame as compared to pushing off the chair’s seat cushion or armrests. Amongst the 13 older frame users the frame’s new handgrips were useful to those living in the community and one person living in care, and they perceived them to facilitate independence and control.

Discussion & conclusions
The novel handgrips offer continuous support when getting up/sitting down and are well-received by those able to use them. The significance of the research lies in the reported number of falls during transfer from sitting to standing and vice versus, with underlying causes reported including loss of support. The proposed design is timely considering the documented increases in frailty and walking aid use in our ageing population.
Pilot randomised controlled trial on the feasibility and intervention satisfaction with an educational group programme for adults with attention deficit hyperactivity disorder and their caregivers
Authors: Skliarova Tatiana , Gråwe Rolf W. , Vaag Jonas , Mandahl Arthur , Kolltveit Inger , Løvås Ina , Torgersen Terje , Lara-Cabrera Mariela L. 
Published: February 2025

Abstract

Background
This pilot randomised controlled trial (RCT) study presents a patient-centred educational group programme collaboratively developed with user representatives and caregivers from two organisations and health personnel from a community mental health centre (CMHC). The objectives were to investigate the feasibility of the psychoeducational programme and the satisfaction of outpatients and caregivers with programme participation. This RCT explored the potential benefits of this innovative psychoeducational programme for adults recently diagnosed with attention deficit hyperactivity disorder (ADHD).

Methods
This pilot study employed a two-arm RCT design and recruited 60 outpatients from a Norwegian CMHC. The CMHC clinicians offered the intervention group (IG) participants a two-session, patient-centred, peer-cofacilitated programme along with the standard treatment. The control group (CG) received the standard treatment and a 1-h individual informational session during the same period. The recruitment, attendance, and dropout rate indicators were assessed for feasibility. Acceptability was assessed via the Client Satisfaction Questionnaire four-item scale (CSQ-4) and a three-item scale evaluating patient satisfaction with the information provided about ADHD. In addition, four patient-reported outcome measures (PROMs) were applied: one scale to assess self-efficacy, two to assess ADHD symptoms, and one for quality of life. The statistical analysis applied intention-to-treat (ITT) and per-protocol (PP) analyses.

Results
In total, 56 outpatients were divided into the IG (n = 30) or CG (n = 26), and the recruitment rate was 93.3%, with a dropout rate of 16%. The attendance rate was 92%, and the retention rates for the IG and CG were 56.6% and 76.9%, respectively. Concerning intervention satisfaction, the ITT analysis conducted using a linear mixed model revealed statistical improvements in satisfaction, with the scale measuring satisfaction with the information and the CSQ-4 scale. In addition, caregivers expressed high satisfaction with the programme, as measured by the CSQ-4 scale. Regarding PROMs, the ITT and PP analyses yielded mixed findings.

Conclusion
Preliminary evidence indicates that a two-session, patient-centred, peer-cofacilitated psychoeducational programme is feasible and well-received, with high ratings for satisfaction from outpatients and caregivers.

Cliniclatrials.gov Identifier
NCT03547843, 27/01/2022.
Comparative analysis between Reverdin-Isham Osteotomy (RIO) and minimally invasive intramedullary nail device (MIIND) in association with AKIN osteotomy for Hallux valgus correction
Authors: Biz Carlo , Bragazzi Nicola Luigi , Di Rita Anna , Pozzuoli Assunta , Belluzzi Elisa , Rodà Maria Grazia , Ruggieri Pietro 
Published: February 2025

Abstract

Background
Hallux valgus (HV) is a widespread condition that leads to discomfort in daily life. There are different surgical techniques for HV. This retrospective and comparative study aimed to compare the clinical and radiographic outcomes of the Reverdin-Isham osteotomy (RIO) and the Minimally Invasive Intramedullary Nail Device (MIIND) surgical techniques.

Methods
One hundred ninety-six patients with mild-to-severe HV were enrolled and divided into two groups: 98 patients with mild-moderate HV and 98 with moderate-severe HV, treated with the RIO and MIIND techniques, respectively. Radiographic and clinical evaluations were assessed preoperatively at 3, 12 and 60 months after surgery. Radiologically, the Hallux Valgus Angle (HVA), Intermetatarsal Angle (IMA), Distal Metatarsal Articular Angle (DMAA) and Tibial Sesamoid Position (TSP) were evaluated. Clinically, the AOFAS hallux metatarsophalangeal-interphalangeal scale and the Numeric Rating Scale (NRS-11) for pain were assessed. A propensity score matching (PSM) model was implemented to compare the two techniques.

Results
In the RIO group, the mean HVA correction from preoperative value to 60 months of follow-up was 8.69° (p < 0.0001), the mean IMA correction was 2.42° (p < 0.0001), and the mean DMAA correction was 0.09°. In the MIIND group, the mean HVA correction was 24.92° (p < 0.0001), the mean IMA correction was 8.75° (p < 0.0001), and the mean DMAA correction was 6.28° (p < 0.0001). The mean AOFAS score improved over time, and NRS-11 decreased in both groups. After PSM model application, the variables that impacted the allocation to RIO or MIIND techniques were age, preoperative HVA values and HV severity.

Conclusion
Our study demonstrates the efficacy of RIO for mild-moderate HV and MIIND for moderate-severe HV. Radiographic and clinical outcomes improved in both groups, but older patients with higher HVA and severe HV should be treated with the MIIND technique to achieve satisfactory outcomes.

Level of evidence
III, retrospective cohort study.
The revised Canadian Bleeding (CAN-BLEED) score for risk stratification of bleeding trauma patients: a mixed retrospective—prospective cohort study
Authors: Tran Alexandre , Lamb Tyler , Fernando Shannon M. , Charette Manya , Nemnom Marie-Joe , Matar Maher , Lampron Jacinthe , Vaillancourt Christian 
Published: February 2025

Abstract

Background
Traumatic hemorrhage is a significant cause of morbidity and mortality. There is considerable interest in risk stratification tools to aid with early activation of intervention pathways for bleeding patients. In this study, we refine the Canadian Bleeding (CAN-BLEED) score for the prediction of major interventions in bleeding trauma patients.

Methods
We conducted a mixed retrospective-prospective cohort study. We included a retrospective cohort from the CAN-BLEED derivation study, from September 2014 to September 2017. We also conducted a prospective cohort from May 2019 to August 2021 and included both datasets for refinement of the CAN-BLEED score. The primary outcome was major intervention, defined by a composite of massive transfusion, embolization, or surgery for hemostasis. Predictors were pre-specified based on previous validation work. We used a stepdown procedure and regression coefficients to create a clinical risk stratification score. We used bootstrap internal validation to assess optimism-corrected performance.

Results
We included 1368 patients in the overall cohort. Incidence of penetrating injury was 23% and median injury severity score was 17. The overall incidence of the need for major intervention was 17%. The revised score included 8 variables: systolic blood pressure, heart rate, lactate, penetrating mechanism, pelvic instability, Focused Abdominal Sonography for Trauma positive for free fluid, computed tomography positive for free fluid, or contrast extravasation. The C-statistic for the simplified score is 0.89. A score cut-off of less than 2 points yielded a 97% (94–98%) sensitivity in ruling out the need for major intervention.

Conclusion
The revised CAN-BLEED score offers a clinically intuitive and internally validated tool with excellent performance in identifying patients requiring major intervention for traumatic bleeding. Further efforts are required to evaluate its performance with an external validation.
Enzymes involved in trehalose-chitin synthesis in Haemonchus contortus could be vaccine candidates for goats
Authors: Wen Zhaohai , Amu Jilata , Aimulajiang Kalibixiati , Feng Jiajun , Chen Cheng , Xu Yongde , Lu Mingmin , Xu Lixin , Song Xiaokai , Li Xiangrui , Yan Ruofeng 
Published: February 2025

Abstract

Background
Trehalose-6-phosphate synthase (HcTPS) and trehalose-6-phosphate phosphatase (HcGOB) are key enzymes for trehalose synthesis in Haemonchus contortus. In addition, previous studies have also demonstrated that HcTPS and HcGOB can regulate the function of host immune cells in vitro, and are important immunosuppressive molecules. Therefore, this study evaluated the potential of HcTPS and HcGOB as vaccine candidates through in vitro and in vivo experiments.

Methods
To evaluate the inhibitory effects of polyclonal antibodies on egg hatching and larval development, anti-rHcTPS and anti-rHcGOB antibodies were incubated separately with eggs and first-stage larvae (L1s) under controlled in vitro conditions. For immunization studies, recombinant proteins (rHcTPS and rHcGOB) were formulated with Quil-A adjuvant, and administered to goats through subcutaneous injection. Vaccine efficacy against Haemonchus contortus infection was determined through comprehensive analysis of multiple parasitological parameters, including: (1) egg abnormality rate, (2) hatching success rate, (3) reduction egg output rates, and (4) reduction in adult worm burden.

Results
The results of in vitro experiments showed that polyclonal antibodies against HcTPS and HcGOB had no effect on the hatching rate of eggs, but significantly affected the development from L1s to infectious third stage larvae (L3s). After immunization with recombinant HcTPS protein (rHcTPS) and recombinant HcGOB protein (rHcGOB), high levels of antigen-specific immunoglobulin G (IgG) were produced in goats, and remained till the end of the experiment. Compared with the Quil-A adjuvant control group, the number of deformed eggs in the rHcTPS protein- immunized group and the rHcGOB protein- immunized group were significantly increased. In the rHcTPS protein-immunized group and the rHcGOB protein-immunized group, the deformity rate of eggs was 9.59% and 17.30%, respectively, and the hatching rate of eggs was reduced by 11.27% and 13.71%, respectively. Moreover, compared with the Quil-A adjuvant control group, the number of eggs and adults in the HcTPS protein- immunized group decreased by 64.47% and 60.93%, respectively, and the number of eggs and adults in the rHcGOB protein- immunized group decreased by 63.97% and 69.54%, respectively. Furthermore, compared with the control group (Quil-A adjuvant), the trehalose content in the rHcTPS protein- immunized group and the rHcGOB protein- immunized group was also significantly reduced.

Conclusions
These findings indicate that rHcTPS and rHcGOB exhibit superior immune protective effects, rendering them promising candidates for vaccine development.

Graphical Abstract
From defensive reasoning to innovation: how digital tools foster positive emotions in organizations
Authors: Tian Guyang , Yang Yang , Zhang Xue , Zhao Manlu , Tian Yezhuang 
Published: February 2025

Abstract
Researchers of organizational learning and innovation have frequently claimed that defensive reasoning is an inducer of negative emotions present in most organizations, inhibiting continuing innovation and development and individuals’ effective learning. Although a significant amount of research has been conducted on the factors that reduce defensive reasoning in an organization, the breakthrough process and its outcomes have not yet been studied. This study uses narrative network analysis on longitudinal data from a Chinese tourist resort to explore how organizational factors—such as institutional environments, social media platforms, and virtual-reality role transformations—help employees overcome defensive reasoning and foster innovation. It demonstrates how digital management tools and corporate social platforms transform negative emotions into positive, creativity-enhancing actions. By analyzing individual defenses from both general and job position perspectives, the study introduces a comprehensive theoretical framework that highlights the role of emotional guidance and digital tools in reducing defensiveness, promoting collaboration, and improving organizational effectiveness and innovation.