bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pengaruh Undang-Undang Cipta Kerja Terhadap Digitalisasi UMKM Di Tengah Pandemi
Authors: Elvlyn Elvlyn , Marhaen Delpedro 
Published: May 2022

Penelitian ini bertujuan untuk membahas perlindungan hukum terhadap pelaku usaha serta dampak UU Cipta Kerja terhadap digitalisasi UMK-M di tengah pandemi. Penelitian ini merupakan kajian hukum yang menggunakan metode penelitian studi kepustakaan yang bersumber pada hukum positif yang berlaku di Indonesia, buku-buku, jurnal, dan karya tulis ilmiah lainnya. Hasil kajian ini menunjukkan perlindungan hukum terhadap pelaku usaha dalam digitalisasi UMK-M meliputi: kemudahan legalitas usahaÂ dan akses informasi; kemudahan pembiayaan dan insentif; larangan usaha besar dan menengah untuk memiliki dan/atau menguasai UMK; mendapatkan alokasi dan jaminan untuk produksi dan pemasaran; dan pemberian layanan bantuan serta pendampingan hukum. UU Cipta Kerja turut berdampak positif dalam mendorong digitalisasi UMK-M di tengah pandemi yang ditandai dengan meningkat transaksi e-commerce,Â nilai transaksi dagang elektronik, nilai transaksi digital banking, dan lain sebagainya.Â
Penyalahgunaan Lem Aibon Bagi Anak-Anak Di Kota Sorong Papua Barat
Authors: Rosalina Febrianti , Cahyani Vita Puspa Ningrum , Putri Violita Ramadhanti 
Published: May 2022

Penulisan karya tulis ilmiah bertujuan untuk memberikan informasi secara konferhensif kepada pembaca tentang penyalahgunaan lem aibonÂ bagi generasi mudaÂ terutama anak-anak. Penelitian ini menggunakan penelitian kualitatif. Sumber data yang digunakan berasal dari data primer dan data sekunder. Hasil penelitian berisi penjelasan tentang kandungan zat yang terdapat pada lem aibon, factor munculnya kebiasaan ngelem pada anak, dampak negatif yang ditimbulkan, bentuk perhatian khusus orang tua terhadap anak, solusi mengatasi termasuk langkah pemerintah dalam penyalahgunaan lem aibon. Dari uraian tersebutÂ disimpulkan bahwa terjadinya penyalahgunaan lem aibonÂ pada generasi muda dapat disebabkan oleh dua faktor yakni: faktor internal dan eksternal.Â
Penanggulangan Dan Pengelolaan Sampah Di Lingkungan Sekolah
Authors: Ponisri Ponisri , Syam Muhammad Ikhzan , Susena Panji Reza 
Published: May 2022

PenelitianÂ ini bertujuan untuk mengetahui jenis-jenis sampah, cara penanggulangan sampah dan cara pengolahan sampah di lingkungan sekolah. Metode yang digunakan adalah metode observasi/pengamatan langsung dan wawancara menggunakan kuiseoner serta studi pustaka. Hasil penelitian ini menunjukkan bahwa ada 2 Â jenis yaitu sampah Â organik (3 jenis) dan sampah organic ( 9 Â jenis). Cara penanggulangan sampah dapat dilakukan dengan mengurangi penggunaan sampah botol/plastik dan kertas sisa makanan, pembakaran, penimbunan dan pengomposan sampah. Sedangkan Â cara pengolahan yang dilakukan di SMP Muhammadiyah Al-Amin Sorong yaitu proses mengurangi sampah (Reduce) dan mendaur ulang (Recycle). Sedangkan dengan cara Â pengolahan Reuse, Replace, Replant, danÂ RepairÂ belum dilakukan.penanggulangan;Â pengolahan;Â sampah
Pemanfaatan Sampah Organik Dan Anorganik Untuk Mendukung Go Green Concept Di Sekolah
Authors: Febriadi Ihsan 
Published: May 2022

Penelitian ini bertujuan untu membedakan jenis-jenis sampah, manfaat dan cara pengolahan sampah di lingkungan sekolah. Sampah dibedakan menjadi dua jenis yaitu sampah organik dan sampah anorganik.Â Sampah organik/mudah busukÂ berasal dari: sisa makanan, sisa sayuran dan kulit buah-buahan, sisa ikan dan daging, sampah kebun (rumput, daun dan ranting). Sampah anorganik/tidak mudah busuk berupa kertas, kayu, kain, kaca, logam, plastik , karet dan tanah.Beberapa manfaat sampah yaitu sebagai kompos/pupuk organik dan sebagai biogas. Sedangkan pengolahan sampah dapat dilakukan beberapa cara yaituÂ ReuseÂ (penggunaan kembali) yaitu menggunakan sampah-sampah tertentu yang masih memungkinkan untuk dipakai [penggunaan kembali botol-botol bekas]. ReduceÂ (pengurangan) yaitu berusaha mengurangi segala sesuatu yang dapat menimbulkan sampah serta mengurangi sampah-sampah yang sudah ada. RecycleÂ (daur ulang) yaitu menggunakan sampah-sampah tertentu untuk diolah menjadi barang yang lebih berguna [daur ulang sampah organik menjadi kompos]. Replace sendiri artinya mengganti, adapun maksudnya yaitu dengan cara mengganti barang yang ramah lingkungan.Â
Pendampingan Belajar Anak Usia Sekolah di Kelurahan Makbusun
Authors: Trisnawati Nika Fetria , Sundari Sundari 
Published: May 2022

Kegiatan pengabdian dilatar belakangi pemikiran bahwa perlunya diberikan pendampingan belajar matematika diluar jam sekolah kepada anak-anak yang bertempat tinggal diÂ Kelurahan Makbusun, sebagian besar mereka mengalami kesulitan dalam pembelajaran matematika dan di Wilayah tersebut Lembaga yang menyediakan jasa Les berlokasi jauh serta biaya yang sulit untuk dijangkau Masyarakat sekitar, sehingga anak-anak hanya bisa mengikuti pembelajaran di Sekolah dan tidak memiliki sarana lain untuk bertanya dan memahami Matematika lebih lanjut. Tujuan dari kegiatan pengabdian ini yaitu Memberikan pendampingan belajar Matematika kepada anak-anak. Dengan harapan anak-anak dapat lebih memahami dan mencintai matematika serta dapat meningkatkan hasil belajar matematika di sekolah. Metode yang digunakan dalam melaksanakan kegiatan pengabdian ini adalah metode ceramah, tanya jawab, penugasan, dan diskusi. Kegiatan pengabdian ini dilaksanakan dalam bentuk bimbingan belajar matematika yang dilaksanakan dua kali dalam satu pekan selama empat bulan kepada 16 anak yang terdiri dari siswa tingkat SD sebanyak 9 anak dan SMP sebanyak 7 anak. BerdasarkanÂ pengamatanÂ selama kegiatan pengabdian kepada masyarakat berlangsung, diperoleh beberapa hasil yang positif, diantaranya adalah: 1). Semangat dan perhatian para peserta yang sangat tinggi dalam mengikuti kegiatan dan juga semangat orang tua yang menginginkan kemajuan untuk anaknya. 2). Terdapat perubahan pemahaman dan pola pikir anak-anak yang tadinya merasa enggan dan takut belajar matematika menjadi senang belajar matematika. 3). Hasil belajar matematika siswa disekolah saat Ulangan Semester menjadi meningkat. Disisi lain, semangat belajar matematika anak-anak usia sekolah di Kelurahan Makbusun Distrik Mayamuk Kabupaten Sorong menjadi meningkat dan hasil belajar matematika di sekolah meningkat.
Peran Guru Dan Orang Tua Dalam Membangun Pendidikan Anak Di Sekolah Dasar Negeri 5 Pulau Raam
Authors: Hidayani Hidayani , Supriadi Supriadi , Rusani Irna , Anwar Zakiyah , Budiarti Marlinda Indah Eka 
Published: May 2022

Kegiatan pengabdian masyarakat dilakukan untuk membangun semangat siswa-siswi dalam belajar. Tempat kegiatan pengabdian masyarakat di Sekolah SD Negeri 5 pulau Raam yang merupakan salah satu kelurahan distrik sorong kepulauan, Pulau Raam, Kota Sorong, Papua Barat. Kondisi pada masa pandemi yang belum diketahui kapan akan berakhir membuat peran orang tua sangat dibutuhkan. kerjasama antara guru dan orang tua sangat diperlukan untuk tercapainya tujuan pendidikan Kemudian kebijakan pemerintah daerah yang membatasi jadwal kegiatan proses belajar mengajar yang membuat guru di sekolah SD Negeri 5 Pulau RaamÂ hanya bisa masuk 3 kali dalam seminggu. Metode yang digunakan dalam melaksnakan kegiatan pengabdian ini yaitu sosialisasi dan diskusi bersama guru dan orang tua. Peserta dari pengabdian kepada masyarakat ini yaitu orang tua atau wali murid siswa-siswi dan Guru SD Negeri 5 Pulau Raam. Jumlah peserta yang mengikuti kegiatan Pengabdian ini sebanyak 15 orang dan 35 orangnya yaitu orang tua atau wali murid SD Negeri 5 pulau Raam. Total peserta sosialisasi yakni berjumlah 50 orang. Kegiatan sosialisai seperti ini sangat diperlukan orang tua agar membuka wawasan orang tua bahwa pembelajaran bukan hanya terjadi disekolah tetapi di rumah juga proses belajar dapat terjadi. Kerjasama antara guruÂ dan orang tua akan tercapai tujuan pendidikan berdasarkan Undang-Undang Dasar..
Climate-Resilient Robotic Facades: Architectural Strategies to Improve Thermal Comfort in Outdoor Urban Environments using Robotic Assembly
Authors: Fleckenstein Julia , Molter Philipp Lionel , Chokhachian Ata , Dörfler Kathrin 
Published: May 2022

In the context of dense urban environments and climate change, pedestrians’ thermal experience plays an increasingly significant role in people’s health and well-being. In this research, the authors combine the fields of architecture, climate-responsive design, and robotic fabrication with the goal of investigating strategies to improve outdoor thermal comfort for pedestrians in cities with frequent extreme heat events. Based on a case study in the city of Munich, this paper presents findings into the technological approaches and methods for location-specific climate-resilient brick facades using robotic assembly. To achieve this goal, different bricklaying patterns were investigated to create a self-shading effect and thus reduce solar radiation and ultimately achieve an improved thermal condition for pedestrians moving along urban facades at street level. Using computer-aided microclimate simulation, generic self-shading brick pattern designs were tailored to highly location-specific microclimate requirements. Robotic assembly technology was used to produce such tailored, non-standard brickwork facades. The results of this research led to a data-informed design process with a demonstrator object being realized at 1:1 scale with a height of 2 m and a length of 3 m using a collaborative robot on site. Thermal measurements on the built demonstrator provided indications of reduced surface temperatures despite high solar radiation and thus validated the location-specific self-shading effects according to solar radiation simulation.
Two Novel Intronic Mutations in the CSF1R Gene in Two Families With CSF1R-Microglial Encephalopathy
Authors: Jiang Jiwei , Li Wenyi , Wang Xiaohong , Du Zhongli , Chen Jinlong , Liu Yaou , Li Wei , Lu Zhonghua , Wang Yanli , Xu Jun 
Published: May 2022

Objective: To describe two novel heterozygous splicing variants of the CSF1R gene responsible for CSF1R-microglial encephalopathy in two unrelated Han Chinese families and further explore the relationship between the pathological and neuroimaging findings in this disease.Methods: The demographic data, detailed medical history, and clinical manifestations of two unrelated Han families with CSF1R-microglial encephalopathy were recorded. Some family members also underwent detailed neuropsychological evaluation, neuroimaging, and genetic testing. The probands underwent whole-exome sequencing (WES) or next-generation sequencing (NGS) to confirm the diagnosis. The findings were substantiated using Sanger sequencing, segregation analysis, and phenotypic reevaluation.Results: Both families presented with a dominant hereditary pattern. Five of 27 individuals (four generations) from the first family, including the proband and his sister, father, uncle, and grandmother, presented with cognitive impairments clinically during their respective lifetimes. Brain magnetic resonance imaging (MRI) depicted symmetric, confluent, and diffuse deep white matter changes, atrophy of the frontoparietal lobes, and thinning of the corpus callosum. The proband’s brother remained asymptomatic; brain MRI revealed minimal white matter changes, but pseudo-continuous arterial spin labeling (pCASL) demonstrated a marked reduction in the cerebral blood flow (CBF) in the bilateral deep white matter and corpus callosum. Seven family members underwent WES, which identified a novel splice-site heterozygous mutation (c.2319+1C&gt;A) in intron 20 of the CSF1R gene in four members. The proband from the second family presented with significant cognitive impairment and indifference; brain MRI depicted symmetric diffuse deep white matter changes and thinning of the corpus callosum. The proband’s mother reported herself to be asymptomatic, while neuropsychological evaluation suggested mild cognitive impairment, and brain MRI demonstrated abnormal signals in the bilateral deep white matter and corpus callosum. NGS of 55 genes related to hereditary leukodystrophy was performed for three members, which confirmed a novel splice-site heterozygous mutation (c.1858+5G&gt;A) in intron 13 of the CSF1R gene in two members.Conclusions: Our study identified two novel splicing mutation sites in the CSF1R gene within two independent Chinese families with CSF1R-microglial encephalopathy, broadening the genetic spectrum of CSF1R-microglial encephalopathy and emphasizing the value of pCASL for early detection of this disease.
Derivation and Validation of a Screening Model for Hypertrophic Cardiomyopathy Based on Electrocardiogram Features
Authors: Guo Lanyan , Gao Chao , Yang Weiping , Ma Zhiling , Zhou Mengyao , Liu Jianzheng , Shao Hong , Wang Bo , Hu Guangyu , Zhao Hang , Zhang Ling , Guo Xiong , Huang Chong , Cui Zhe , Song Dandan , Sun Fangfang , Liu Liwen , Zhang Fuyang , Tao Ling 
Published: May 2022

BackgroundHypertrophic cardiomyopathy (HCM) is a widely distributed, but clinically heterogeneous genetic heart disease, affects approximately 20 million people worldwide. Nowadays, HCM is treatable with the advancement of medical interventions. However, due to occult clinical presentations and a lack of easy, inexpensive, and widely popularized screening approaches in the general population, 80–90% HCM patients are not clinically identifiable, which brings certain safety hazards could have been prevented. The majority HCM patients showed abnormal and diverse electrocardiogram (ECG) presentations, it is unclear which ECG parameters are the most efficient for HCM screening.ObjectiveWe aimed to develop a pragmatic prediction model based on the most common ECG features to screen for HCM.MethodsBetween April 1st and September 30th, 2020, 423 consecutive subjects from the International Cooperation Center for Hypertrophic Cardiomyopathy of Xijing Hospital [172 HCM patients, 251 participants without left ventricular hypertrophy (non-HCM)] were prospectively included in the training cohort. Between January 4th and February 30th, 2021, 163 participants from the same center were included in the temporal internal validation cohort (62 HCM patients, 101 non-HCM participants). External validation was performed using retrospectively collected ECG data from Xijing Hospital (3,232 HCM ECG samples from January 1st, 2000, to March 31st, 2020; 95,184 non-HCM ECG samples from January 1st to December 31st, 2020). The C-statistic was used to measure the discriminative ability of the model.ResultsAmong 30 ECG features examined, all except abnormal Q wave significantly differed between the HCM patients and non-HCM comparators. After several independent feature selection approaches and model evaluation, we included only two ECG features, T wave inversion (TWI) and the amplitude of S wave in lead V1 (SV1), in the HCM prediction model. The model showed a clearly useful discriminative performance (C-statistic &gt; 0.75) in the training [C-statistic 0.857 (0.818–0.896)], and temporal validation cohorts [C-statistic 0.871 (0.812–0.930)]. In the external validation cohort, the C-statistic of the model was 0.833 [0.825–0.841]. A browser-based calculator was generated accordingly.ConclusionThe pragmatic model established using only TWI and SV1 may be helpful for predicting the probability of HCM and shows promise for use in population-based HCM screening.
Numerical Simulation of Long-Term Deterioration of Rock Mass Supported by Shotcrete Lining
Authors: Kong Chao , Wang Haiyan , Zhao Kai , Gao Xinqiang 
Published: May 2022

The deterioration of rock mass and shotcrete lining has major consequences on the long-term performance of tunnels in the weak rock mass. In this study, the long-term behavior of rock mass and shotcrete in tunnels was simulated by using the three-dimensional finite difference method, considering the nonlinear deterioration mechanism. The degradation of rock mass was simulated by weakening the mechanical parameters, while the deterioration of shotcrete was modeled by decreasing the thickness. The support pressure, internal force, and displacement of the secondary lining were monitored with the gradual degradation of rock mass and shotcrete. As a consequence, the factor of safety (FoS) evolution with time was discussed. The results indicated that 1) the deterioration of both rock mass and shotcrete would significantly increase the rock pressure on the secondary lining, leading to an increase in the displacement (0–14 mm). The FoS of the secondary lining was reduced by 85%. 2) The influence of shotcrete’s deterioration on the secondary lining was relatively less, and the rock pressure on the secondary lining increased from 0 kPa to 13.8 kPa. The long-term safety of the tunnel is remarkably affected by the deterioration of rock mass, depending on the deterioration characteristics of the rock mass. Therefore, the deterioration characteristics of rock mass should be fully considered in tunnel maintenance.
Clinicopathologic Characteristics and Outcomes of Massive Multinodular Goiter: A Retrospective Cohort Study
Authors: Chen Qiang , Su Anping , Zou Xiuhe , Liu Feng , Gong Rixiang , Zhu Jingqiang , Li Zhihui , Wei Tao 
Published: May 2022

BackgroundThyroidectomy for massive goiters is challenging because of the increased risk of tracheomalacia, combined sternotomy, postoperative morbidity, and mortality, whereas studies investigating the clinicopathologic characteristics, postoperative morbidities, and surgical outcomes of massive goiters are limited.MethodsPatients with goiters undergoing thyroid surgery between 2009 and 2019 were retrospectively reviewed. A total of 227 patients were enrolled and divided into massive goiter group and large goiter group according to the weight of the goiter. Clinicopathologic characteristics, postoperative morbidities, and surgical outcomes were compared between the two groups.ResultsSeventy-four patients (32.6%) had a goiter weighing more than 250 g and 153 patients (67.4%) were categorized in the large goiter group. Compared to large goiter patients, massive goiter patients had higher rates of retrosternal extension (82.4% vs. 30.7%), combined sternotomy (12.2% vs. 1.3%), intensive care unit admission (25.7% vs. 7.2%), transient hypoparathyroidism (41.9% vs. 25.5%), and transient recurrent laryngeal nerve palsy (10.8% vs. 3.3%) as well as prolonged length of hospital stay (P &lt; 0.05).ConclusionsMassive goiter patients were at increased risk of combined sternotomy, intensive care unit admission, postoperative morbidities as well as prolonged length of hospital stay after thyroidectomy compared to large goiter patients, but most of them can be treated through a cervical approach with a favorable outcome.
A Prognostic Signature for Clear Cell Renal Cell Carcinoma Based on Ferroptosis-Related lncRNAs and Immune Checkpoints
Authors: Dong Yunze , Liu Ding , Zhou Hongmin , Gao Yuchen , Nueraihemaiti Yimingniyizi , Xu Yunfei 
Published: May 2022

Background: Ferroptosis is a potential target for cancer therapy, and lncRNAs can also affect ferroptosis by regulating related genes. The pathogenesis of clear cell renal cell carcinoma (ccRCC) regarding the regulation of ferroptosis by lncRNAs is still unknown.Methods: We constructed a risk model based on data in ccRCC patients obtained from the TCGA database and validated the diagnostic and prognostic value of the model. In addition, immune function and immune checkpoint variability analysis validated the association of ferroptosis with ccRCC tumor immunity.Results: The characteristics of ferroptosis-related lncRNAs (FRLs) were significantly correlated with the prognosis of ccRCC patients. The prognostic characteristics of FRLs were independent prognostic factors in ccRCC patients. Gene function in the high-risk group was associated with oxygen metabolic processes and immune pathways. Immune checkpoint variability analysis showed that HAVCR2, NRP1, and HHLA2 were upregulated in the low-risk group, while CD44, TNFRSF18, TNFSF14, TNFRSF8, CD276, and TNFRSF25 were upregulated in the high-risk group.Conclusions: The prognostic characteristics of FRLs can effectively predict the prognosis of ccRCC patients and provide a new direction for clinical treatment.
The Distribution Pattern of Ocular Residual Astigmatism in Chinese Myopic Patients
Authors: Tang Changting , Du Zijing , Wu Guanrong , Tan Xuanyun , Zang Siwen , Yu Honghua , Hu Yijun 
Published: May 2022

PurposeWe aimed to investigate the distribution of ocular residual astigmatism (ORA) and its associations with age, gender, manifest refraction, and other ocular indicators in Chinese patients with myopia.DesignThis is a multi-center retrospective cross-sectional study.MethodThe study included 7,893 patients with myopia (7,893 eyes) aged 18–40 years from five ophthalmic centers. Anterior segment biometrics of the eyes were collected from the Pentacam. ORA and its summated vector mean were calculated using Alpins vector analysis. Compensation factor (CF) was used to evaluate the relation between ORA and corneal astigmatism. ORA in different age, gender, and refraction groups was compared. The Spearman correlation was adopted to reveal multiple ocular indicators associated with ORA, which were integrated into a multiple linear regression model to predict ORA.ResultsDistribution of ORA was slightly positively skewed (Skewness= 2.111, Kurtosis = 19.660, KS P &lt; 0.0001). Mean ORA was 0.74 ± 0.39 D (95% normal range: 0.14–1.54 D). Among all the subjects, 22.4% of the eyes had an ORA magnitude of 1.0 D or more. Undercompensation or full-compensation of anterior corneal astigmatism (ACA) by ORA prevailed in both J0 (76.99%) and J45 (58.48%). Women had higher ORA power than men (0.77 ± 0.36 D vs. 0.73 ± 0.41 D, P &lt; 0.0001). Participants with less negative spherical equivalent (SE) or higher manifest astigmatism (MA) also had higher ORA (all P &lt; 0.0001). ORA was significantly correlated with ACA (r = 0.405) and posterior corneal astigmatism (PCA, r = 0.356). The multivariate logistic regression analysis showed strong predictability of ORA magnitude &gt;1.0 D using anterior segment parameters (area under the receiver operating characteristic curve: 0.739).ConclusionORA is present in Chinese adults with myopia and is affected by multiple ocular factors. Our findings may provide valuable information about ORA distribution in candidates for refractive surgery, helping optimize the outcome of astigmatism correction.