bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison of non-operative versus operative management of resectable colorectal cancer in elderly patients: study protocol for a systematic review
Authors: Hu Richard , Selvam Rajajee , Moloo Husein , Williams Lara , Raiche Isabelle , Musselman Reilly 
Published: April 2022

Abstract
Background
In the 2021 Statistics Canada census, 18.5% of the Canadian population were senior (65 years and older), among those 1.7 million (4.5%) were aged 80 years and older. Colorectal cancer (CRC) is the third most common cancer in both men and women, with its highest incidence rate in septu- and octogenarians. As clinicians encounter a growing number of very elderly patients (80 years and older) with resectable colorectal cancer, justifying major surgery in a comorbid population with limited life expectancy is difficult. Therefore, this study aims to systemically review the available literature to compare non-operative management to surgical resection with respect to overall survival and quality of life.

Method
We designed and registered a study protocol for a systematic review. We will include all patients above the age of 80 with resectable colorectal cancer. We will search MEDLINE, EMBASE, and the Cochrane Database of Controlled Trials from January 2000 onwards. We will include randomized, non-randomized controlled trials and observational studies comparing non-operative versus operative management of resectable colorectal cancer in elderly patients. The primary outcomes will be overall survival and mortality. Secondary outcomes will include quality of life, and health services/ resources utilization (e.g., treatments, change of level of care…). Two reviewers will independently screen all citations, full-text articles, and abstract data. Potential conflicts will be resolved through discussion. The study methodological quality (or bias) will be appraised using the ROB-2 and ROBIN-I tools. If feasible, we will conduct random effects meta-analysis. Additional analyses will be conducted to explore the potential sources of heterogeneity (e.g., study design and methodological quality).

Discussion
This systematic review will synthesize the existing data on the management of colorectal cancer in the very elderly patients, and identify the gap in the literature for potential future research. More specifically, we aim to streamline non-operative outcome data on resectable colorectal cancers to aid clinicians’ decision-making with respect to survival outcomes and quality of life. The results of this study will be of interest to multiple audiences including patients, their families, caregivers, healthcare professionals, and policy makers. Results will be published in a peer-reviewed journal.
Multiple scenario simulation and optimization of an urban green infrastructure network based on complex network theory: a case study in Harbin City, China
Authors: Song Shuang , Wang Shao-Han , Shi Meng-Xi , Hu Shan-Shan , Xu Da-Wei 
Published: April 2022

Abstract
Background
Urban green infrastructure (GI) networks play a significant role in ensuring regional ecological security; however, they are highly vulnerable to the influence of urban development, and the optimization of GI networks with better connectivity and resilience under different development scenarios has become a practical problem that urgently needs to be solved. Taking Harbin, a megacity in Northeast China, as the case study, we set five simulation scenarios by adjusting the economic growth rate and extracted the GI network in multiple scenarios by integrating the minimal cumulative resistance model and the gravity model. The low-degree-first (LDF) strategy of complex network theory was introduced to optimize the GI network, and the optimization effect was verified by robustness analysis.

Results
The results showed that in the 5% economic growth scenario, the GI network structure was more complex, and the connectivity of the network was better, while in the other scenarios, the network structure gradually degraded with economic growth. After optimization by the LDF strategy, the average degree of the GI network in multiple scenarios increased from 2.368, 2.651, 2.189, 1.972, and 1.847 to 2.783, 3.125, 2.643, 2.414, and 2.322, respectively, and the GI network structure connectivity and resilience were significantly enhanced in all scenarios.

Conclusions
Economic growth did not necessarily lead to degradation of the GI network; there was still room for economic development in the study area, but it was limited under existing GI conditions, and the LDF strategy was an effective method to optimize the GI network. The research results provide a new perspective for the study of GI network protection with urban economic growth and serve as a methodological reference for urban GI network optimization.
Acupuncture for allergic rhinitis: a systematic review and meta-analysis
Authors: He Min , Qin Weishan , Qin Zongshi , Zhao Changqing 
Published: April 2022

Abstract
Background
In this study, we attempted to assess the efficacy and safety of acupuncture for allergic rhinitis (AR), and to test the robustness of the estimated effects.

Methods
The Cochrane methodology standard was followed to conduct this systematic review. Randomized controlled trials (RCTs) comparing acupuncture with other therapies for AR were included. Furthermore, trial sequential analysis was conducted to test the robustness of pooled results. Thirty trials with 4413 participants were included.

Results
Acupuncture improved the nasal symptoms on Total Nasal Symptom Score (TNSS) and quality of life measured by Rhinoconjunctivitis Quality of Life Questionnaire (RQLQ) in adults with AR, compared to acupuncture with no intervention. Acupuncture was also shown to be more effective than sham acupuncture for nasal symptom (RQLQ subscale, n = 489, MD − 0.60, 95% CI − 1.16 to − 0.04) and quality of life (RQLQ, n = 248, − 8.47 95% CI − 14.91, − 2.03). No clear difference was observed between acupuncture and cetirizine or loratadine. Interestingly, trial sequential analysis (TSA) failed to confirm the aforementioned results. The effect of acupuncture for children/adolescents with AR remains unclear due to insufficient data. The performance bias and attrition bias are serious in most studies that were included. Selection bias may also have affected the quality of the evidence.

Conclusion
Acupuncture may have an advantage over no intervention and sham acupuncture in improving nasal symptoms and quality of life for adults with AR. The effect of acupuncture and cetirizine or loratadine for AR may be similar. Additional trials are necessary to confirm these results.
Mesenchymal stromal cells from a progressive pseudorheumatoid dysplasia patient show altered osteogenic differentiation
Authors: Pulsatelli Lia , Manferdini Cristina , Gabusi Elena , Mariani Erminia , Ursini Francesco , Ciaffi Jacopo , Meliconi Riccardo , Lisignoli Gina 
Published: April 2022

Abstract
Background
Progressive pseudorheumatoid dysplasia (PPRD) is a rare autosomal recessive non-inflammatory skeletal disease with childhood onset and is characterized by a progressive chondropathy in multiple joints, and skeletal abnormalities. To date, the etiopathological relationship between biological modification occurring in PPRD and genetic mutation remains an open issue, partially due to the limited availability of biological samples obtained from PPRD patients for experimental studies.

Case presentation
We describe the clinical features of a PPRD patient and experimental results obtained from the biological characterization of PPRD mesenchymal stromal cells (MSCs) and osteoblasts (OBs) compared to normal cell populations. Phenotypic profile modifications were found in PPRD compared to normal subjects, essentially ascribed to decreased expression of CD146, osteocalcin (OC) and bone sialoprotein in PPRD MSCs and enhanced CD146, OC and collagen type I expression in PPRD OBs. Gene expression of Dickkopf-1, a master inhibitor of WNT signaling, was remarkably increased in PPRD MSCs compared to normal expression range, whereas PPRD OBs essentially exhibited higher OC gene expression levels. PPRD MSCs failed to efficiently differentiate into mature OBs, so showing a greatly impaired osteogenic potential.

Conclusions
Since all regenerative processes require stem cell reservoirs, compromised functionality of MSCs may lead to an imbalance in bone homeostasis, suggesting a potential role of MSCs in the pathological mechanisms of PPRD caused by WNT1-inducible signaling pathway protein-3 (WISP3) mutations. In consideration of the lack of compounds with proven efficacy in such a rare disease, these data might contribute to better identify new specific and effective therapeutic approaches.
Comparative study of the effect of solvents on the efficacy of neonicotinoid insecticides against malaria vector populations across Africa
Authors: Tchouakui Magellan , Assatse Tatiane , Mugenzi Leon M. J. , Menze Benjamin D. , Nguiffo-Nguete Daniel , Tchapga Williams , Kayondo Jonathan , Watsenga Francis , Manzambi Emile Zola , Osae Michael , Wondji Charles S. 
Published: April 2022

Abstract
Background
New insecticides with a novel mode of action such as neonicotinoids have recently been recommended for public health by WHO. Resistance monitoring of such novel insecticides requires a robust protocol to monitor the development of resistance in natural populations. In this study, we comparatively used three different solvents to assess the susceptibility of malaria vectors to neonicotinoids across Africa.

Methods
Mosquitoes were collected from May to July 2021 from three agricultural settings in Cameroon (Njombe-Penja, Nkolondom, and Mangoum), the Democratic Republic of Congo (Ndjili-Brasserie), Ghana (Obuasi), and Uganda (Mayuge). Using the CDC bottle test, we compared the effect of three different solvents (ethanol, acetone, MERO) on the efficacy of neonicotinoids against Anopheles gambiae s.l. In addition, TaqMan assays were used to genotype key pyrethroid-resistant markers in An. gambiae and odds ratio based on Fisher exact test were used to evaluate potential cross-resistance between pyrethroids and clothianidin.

Results
Lower mortality was observed when using absolute ethanol or acetone alone as solvent for clothianidin (11.4‒51.9% mortality in Nkolondom, 31.7‒48.2% in Mangoum, 34.6‒56.1% in Mayuge, 39.4‒45.6% in Obuasi, 83.7‒89.3% in Congo and 71.1‒95.9% in Njombe pendja) compared to acetone + MERO for which 100% mortality were observed for all the populations. Similar observations were done for imidacloprid and acetamiprid. Synergist assays (PBO, DEM and DEF) with clothianidin revealed a significant increase of mortality suggesting that metabolic resistance mechanisms are contributing to the reduced susceptibility. A negative association was observed between the L1014F-kdr mutation and clothianidin resistance with a greater frequency of homozygote resistant mosquitoes among the dead than among survivors (OR = 0.5; P = 0.02). However, the I114T-GSTe2 was in contrast significantly associated with a greater ability to survive clothianidin with a higher frequency of homozygote resistant among survivors than other genotypes (OR = 2.10; P = 0.013).

Conclusions
This study revealed a contrasted susceptibility pattern depending on the solvents with ethanol/acetone resulting to lower mortality, thus possibly overestimating resistance, whereas the MERO consistently showed a greater efficacy of neonicotinoids but it could prevent to detect early resistance development. Therefore, we recommend monitoring the susceptibility using both acetone alone and acetone + MERO (4 µg/ml for clothianidin) to capture the accurate resistance profile of the mosquito populations.

Graphical Abstract
Longitudinal dynamics of microvascular recovery after acquired cortical injury
Authors: Lin Xiaoxiao , Chen Lujia , Jullienne Amandine , Zhang Hai , Salehi Arjang , Hamer Mary , C. Holmes Todd , Obenaus Andre , Xu Xiangmin 
Published: April 2022

AbstractAcquired brain injuries due to trauma damage the cortical vasculature, which in turn impairs blood flow to injured tissues. There are reports of vascular morphological recovery following traumatic brain injury, but the remodeling process has not been examined longitudinally in detail after injury in vivo. Understanding the dynamic processes that influence recovery is thus critically important. We evaluated the longitudinal and dynamic microvascular recovery and remodeling up to 2 months post injury using live brain miniscope and 2-photon microscopic imaging. The new imaging approaches captured dynamic morphological and functional recovery processes at high spatial and temporal resolution in vivo. Vessel painting documented the initial loss and subsequent temporal morphological vascular recovery at the injury site. Miniscopes were used to longitudinally image the temporal dynamics of vascular repair in vivo after brain injury in individual mice across each cohort. We observe near-immediate nascent growth of new vessels in and adjacent to the injury site that peaks between 14 and 21 days post injury. 2-photon microscopy confirms new vascular growth and further demonstrates differences between cortical layers after cortical injury: large vessels persist in deeper cortical layers (> 200 μm), while superficial layers exhibit a dense plexus of fine (and often non-perfused) vessels displaying regrowth. Functionally, blood flow increases mirror increasing vascular density. Filopodia development and endothelial sprouting is measurable within 3 days post injury that rapidly transforms regions devoid of vessels to dense vascular plexus in which new vessels become increasingly perfused. Within 7 days post injury, blood flow is observed in these nascent vessels. Behavioral analysis reveals improved vascular modulation after 9 days post injury, consistent with vascular regrowth. We conclude that morphological recovery events are closely linked to functional recovery of blood flow to the compromised tissues, which subsequently leads to improved behavioral outcomes.
Vehicle routing problems based on Harris Hawks optimization
Authors: Alweshah Mohammed , Almiani Muder , Almansour Nedaa , Al Khalaileh Saleh , Aldabbas Hamza , Alomoush Waleed , Alshareef Almahdi 
Published: April 2022

AbstractThe vehicle routing problem (VRP) is one of the challenging problems in optimization and can be described as combinatorial optimization and NP-hard problem. Researchers have used many artificial intelligence techniques in order to try to solve this problem. Among these techniques, metaheuristic algorithms that can perform random search are the most promising because they can be used to find the right solution in the shortest possible time. Therefore, in this paper, the Harris hawks optimization (HHO) algorithm was used to attempt to solve the VRP. The algorithm was applied to 10 scenarios and the experimental results revealed that the HHO had a strong ability to check for and find the best route as compared to other metaheuristic algorithms, namely, simulated annealing and artificial bee colony optimization. The comparison was based on three criteria: minimum objective function obtained, minimum number of iterations required and satisfaction of capacity constraints. In all scenarios, the HHO showed clear superiority over the other methods.
Upper and lower plane bed definitions revised
Authors: Ohata Koji , Naruse Hajime , Izumi Norihiro 
Published: April 2022

AbstractSedimentary structures in ancient deposits are clues to reconstruct past geohazards. While parallel lamination formed by plane beds is one of the most common sedimentary structures in event deposits such as turbidites, the formative conditions for plane beds remain unclear. In the literature, two types of plane beds (upper and lower plane beds) exist and are supposed to develop under different shear stresses, particle sizes, and flow regimes. Here, we present new phase diagrams based on the compilation of existing data regarding formative hydraulic conditions for plane beds to clarify the formation processes associated with the two types of plane beds. The diagrams indicated that the data form two separate populations and the gap between them corresponds to the threshold condition of the particle entrainment into suspension. Lower plane beds form when sediment particles move only as bed load. This phase space can be discerned from fine sand to gravel and differs from the conventional view in which the formation of the lower plane bed is limited to grain sizes above 0.7 mm. In addition, our phase diagrams suggest that upper plane beds appear under conditions of the active suspended load. Our analyses demonstrate that the suspended load contributes to the formation of plane beds, whereas other mechanisms can also produce fine-grained plane beds in flows with low bed shear stress. Thus, the results of this study suggest that the existing interpretations on fine-grained parallel lamination such as Bouma’s Tddivision need to be reconsidered. The bedform phase diagrams newly established in this study will be useful for estimating the flow conditions from the geologic records of event beds.
Opinion dynamics in finance and business: a literature review and research opportunities
Authors: Zha Quanbo , Kou Gang , Zhang Hengjie , Liang Haiming , Chen Xia , Li Cong-Cong , Dong Yucheng 
Published: April 2022

AbstractOpinion dynamics is an opinion evolution process of a group of agents, where the final opinion distribution tends to three stable states: consensus, polarization, and fragmentation. At present, the opinion dynamics models have been extensively studied in differrent fields. This paper provides a review of opinion dynamics in finance and business, such as, finance, marketing, e-commerce, politics, and group decision making. Furthermore, identified research challenges have been proposed to promote the future research of this topic.
Social inequalities experienced by children of immigrants across multiple domains of life: a case study of the Windrush in England and Wales
Authors: Wallace Matthew , Wilson Ben , Darlington-Pollock Frances 
Published: April 2022

AbstractIt is well known that children of immigrants experience inequality. Less is known about how inequalities compare across multiple life domains and multiple generations. We conduct a case study of England and Wales, focussing on children of Caribbean immigrants (the ‘Windrush generation’). We use large-scale census data to compare inequalities across five domains of life—education, employment, occupation, housing, and health—separately for women and men across three distinct generations: the one-point-five generation, second-generation, and two-point-five generation. The children of the Windrush generation experience social inequality in all life domains, relative to comparable groups of the White British population, although there is considerable variation according to sex and generation. Men of all generations are uniformly disadvantaged; children of the Windrush are more disadvantaged if they belong to the two-point-five generation. Inequality is pervasive, persistent, and strongly indicative of segmented adaptation.
Assessing and managing attention-deficit hyperactivity disorder in people with intellectual disability
Authors: Perera Bhathika , McCarthy Jane , Courtenay Ken 
Published: April 2022

SUMMARYAttention-deficit hyperactivity disorder (ADHD) is a common neurodevelopmental disorder with a higher prevalence rate in people with intellectual disability compared with their peers without such disability. The classic presentation is that of inattention and/or hyperactivity and impulsivity, but these symptoms can manifest differently in people with intellectual disability. Despite a higher prevalence, the rate of diagnosis and treatment of ADHD in intellectual disability remains low. This article discusses the clinical presentation of ADHD in people with intellectual disability and the relationship between ADHD and other comorbid conditions, such as autism and bipolar disorder. Pharmacological and non-pharmacological interventions are discussed from a practical and a clinical point of view.
Combined Nerve and Tendon Transfers for C7-T1 Brachial Plexus Avulsion Injury
Authors: Xu Bin , Tong Jing-Song , Dong Zhen , Zhang Cheng-Gang , Gu Yu-Dong 
Published: April 2022

BACKGROUND:
In patients with C7-T1 brachial plexus avulsions, complete loss of hand function is commonly seen. However, the reconstruction of hand function is difficult.

OBJECTIVE:
To report the outcomes of hand function recovery after combined nerve and tendon transfers in C7-T1 brachial plexus injury.

METHODS:
From 2012 to 2019, 8 patients with C7-T1 brachial plexus injury underwent combined nerve and tendon transfers for hand function restoration, which included the following: (1) the pronator teres motor branch to the anterior interosseous nerve and brachialis motor branch to the flexor digitorum superficialis branch for finger flexion, (2) the supinator motor branch to the posterior interosseous nerve for finger extension, (3) the brachioradialis tendon transfer for thumb opposition, and (4) the radial branch of the superficial radial nerve to the sensory branch of the ulnar nerve for sensory reconstruction. Patients were evaluated for functional improvement of finger flexion, finger extension, thumb opposition, and sensory recovery.

RESULTS:
No clinical donor deficits were observed. Seven of eight patients recovered finger and thumb flexion (4 patients scored British Medical Research Council grade M4 and 3 scored M3). The average grip strength was 3.4 kg. All patients regained finger extension (4 scored M4 and 4 scored M3), thumb opposition, and protective sensation on the ulnar hand. Patients were able to use their reconstructed hands in daily lives.

CONCLUSION:
Combined nerve and tendon transfers are reliable and effective. This strategy could be an option for hand function reconstruction after C7-T1 brachial plexus injury.
Clinical efficacy of Vortioxetine and escitalopram in the treatment of depression
Authors: Shao Shichuan , Sun Baomin , Sun Huiqing 
Published: April 2022

Objectives: This study was aimed to investigate the efficacy and safety of vortioxetine hydrobromide in the treatment of major depressive disorder (MDD).
Methods: One hundred and eighty patients with the newly diagnosed depression in our hospital between August 2018 and August 2019 were selected and randomly divided into an observation group and a control group, 90 each group. The control group was treated with escitalopram, and the observation group was treated with voltaxetine. The efficacy and adverse reactions were evaluated by the Hamilton Depression scale-17 (HAMD-17), Sheehan Disability Scale (SDS), Perceived Deficits Questionnaire-Depression (PDQ-D), and treatment emergent symptom scale (TESS) before treatment and at the end of the 8th and 24th week after treatment.
Results: At the end of the 8th and 24th week after treatment, the HAMD-17 scores of the two groups were lower than those before treatment (P<0.05); at the end of the 8th and 24th week after treatment, the PDQ-D and SDS scores of the two groups were lower than those before treatment (P<0.05), and the above scores of the observation group were lower than those of the control group (P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05).
Conclusion: Voltaxetine can improve cognitive function and clinical symptoms of patients with severe depression and has high safety, which is worth clinical attention.
doi: https://doi.org/10.12669/pjms.38.5.5230
How to cite this:Shao S, Sun B, Sun H. Clinical efficacy of Vortioxetine and escitalopram in the treatment of depression. Pak J Med Sci. 2022;38(5):---------. doi: https://doi.org/10.12669/pjms.38.5.5230
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.