bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identification of Pyroptosis Genes in cervical cancer and construction of a prognostic model for pyroptosis-associated mRNA
Authors: Kang Haojing , Wu Yinying , Yan Yanli , Bai Shuheng , Li Rong , Feng Zhaode , Xuan Wang , Li Guangzu , Li Wenyang , Liu Wanyi , Wu Fang , Hu Fengyuan , Zhang Xiangxiang , Yang Yiping , Ren Juan 
Published: September 2022

Abstract
Cervical squamous cell carcinoma and endocervical adenocarcinoma(CESC) is one of the more common tumors in women worldwide and has a higher mortality rate. However, there is a paucity of information about specific biomarkers that assist in the diagnosis and prognosis of CESC. The development of a specific prognostic model is important if we are to improve treatment strategies. Pyroptosis is a form of programmed cell death, and its different elements are related to the occurrence, invasion and metastasis of tumors. However, the role of pyroptosis in CESC progression has not been clarified. The focus of this study is to use comprehensive bioinformatics to develop pyroptosis prognostic characteristics of CESC, so as to delineate the relationship among this characteristic, tumor microenvironment and immune response of patients. In combination with clinical characteristics, risk score is an independent predictor of OS in patients with CESC. Pyroptosis Genes(PRG) score was significantly correlated with immune score, immune infiltration, immune microenvironment, cancer stem cell (CSC) index, and chemotherapeutic drug sensitivity. These findings may improve our understanding of PRGs in CESC and provide new avenues for assessing prognosis and developing more effective immunotherapeutic strategies.
Acoustic metamaterials driven transdermal drug delivery for rapid and on-demand management of acute disease
Authors: Xu Junhua , Cai Hongwei , Wu Zhuhao , Tian Chunhui , Li Xiang , Ao Zheng , Niu Vivian , Xiao Xiao , Jiang Lei , Khodoun Marat , Rothenberg Marc , Mackie Ken , Chen Jun , Lee Luke , Guo Feng 
Published: September 2022

Abstract
Transdermal drug delivery provides convenient and pain-free self-administration for personalized therapy. However, challenges remain in treating acute disease largely due to their inability to timely administrate therapeutics and precisely regulate pharmacokinetics within a short time window. Here we report the development of active acoustic metamaterials driven transdermal drug delivery for rapid and on-demand management of the acute disease. Through the integration of active acoustic metamaterials, a compact therapeutic patch is integrated for penetration of skin stratum corneum and active percutaneous transport of therapeutics with precise control of dose and rate over time. Moreover, the patch device quantitatively regulates the dosage and release kinetics of therapeutics and achieves better delivery performance in vivo than through subcutaneous injection. As a proof-of-concept application, our method can reverse life-threatening acute allergic reactions in a mouse model of anaphylaxis via a multi-burst delivery of epinephrine, showing better efficacy than a fixed dosage injection of epinephrine as the current gold standard Epi-pen strategy. This innovative method may provide a promising means to manage the acute disease for personalized medicine.
Suppression of prostate cancer cell growth by mid-infrared rays
Authors: Shima Junko , Igarashi Seiji 
Published: September 2022

Abstract
Experiments using rubber/resin foam (RB) have already shown that far-infrared rays suppress the proliferation of cancer cells1. We will report as a follow up to these findings. When RB was used, the temperature of the culture solution increased by about 0.4°C. This time, with a focus on this temperature rise, a new heating plate was manufactured, and culture experiments were conducted without using RB. It was determined that the suppression of growth was because of heat transfer, not due to the special action of RB. The distribution of heat was calculated using Planck's formula, and it was speculated that mid-infrared rays around 4.8 µm are involved in the inhibition of cancer cell proliferation. Furthermore, irradiation with a 4.8 µm mid-infrared free electron laser confirmed that the ratio of α-helix to β-sheet changed, providing corroborative evidence for growth suppression.
Outlining the Molecules Tested In Vivo for Chagas Disease, Malaria,
and Schistosomiasis Over the Last Six Years - A Literature Review
Focused on New Synthetic Drug Identities and Repurposing Strategies
Authors: de Melo Silva Vanessa Gouveia , da Conceição Juliana Maria , Vieira Costa Silva Carla Cauanny , Leal Amanda Calazans , Araújo Daniel Lopes , Nunes Janine Siqueira , da Silva Elineide Tayse Noberto , da Silva Anderson José Firmino Santos , de Barros Dias Mabilly Cox Holanda , Lima Leite Ana Cristina 
Published: September 2022

Background:
COVID-19 disrupted NTD programs in 60% of countries, impairing
public health goals. Thus, boosting NTD's research knowledge is demanding, and
in vivo screening of candidates allows for the prospect of promising options based on their
overall profile.

Objective:
In this work, we highlighted the relevant research done between 2015-2021 in
the fields of synthetic and repurposed drugs that were tested in vivo for Chagas disease,
malaria, and schistosomiasis.

Methods:
MEDLINE, PUBMED, CAPES PERIODIC, and ELSEVIER databases were used
for a comprehensive literature review of the last 6 years of research on each area/disease.

Results:
Overall, research focused on nitro heterocyclic, aromatic nitro, nucleoside, and
metal-based scaffolds for analogue-based drug generation. Repurposing was widely assessed,
mainly with heterocyclic drugs, their analogues, and in combinations with current
treatments. Several drug targets were aimed for Chagas treatment, specific ones such as iron
superoxide dismutase, and more general ones, such as mitochondrial dysfunction. For malaria,
hemozoin is still popular, and for schistosomiasis, more general structural damage and/or
reproduction impairment were aimed at in vitro analysis of the mechanism of action.

Conclusion:
Latest in vivo results outlined trends for each disease - for Chagas Disease,
heterocyclics as thiazoles were successfully explored; for Malaria, quinoline derivatives
are still relevant, and for schistosomiasis, repurposed drugs from different classes outstood
in comparison to synthetic compounds. This study uprises the continuous development
of Chagas disease, malaria, and schistosomiasis drugs, providing researchers with
tools and information to address such unmet therapeutic needs.
Research Progress of Vitamin K2 Related Signal Pathways: A Literature
Review
Authors: Li Shimin , Ouyang Xiao 
Published: September 2022

Abstract:
Vitamin K2 products were first applied to Japanese children, which can promote the growth of
children's bones and eliminate their growing pain. At the same time, it does little harm to the human body,
so it has attracted the attention of some scholars. Later, it was also proved to be effective in treating osteoporosis,
especially for postmenopausal women. After years of research, some capabilities of VK2 have
been discovered; it has been proved that it has great clinical value in treating osteoporosis, reducing intimal
lipid deposition, diabetes, tumor, immune diseases, nervous system diseases and other diseases. There
is no doubt that VK2 is an essential nutrient for human health, once vitamin K2 is deficient, it will cause a
series of diseases. In recent years, some new evidences show that VK2 can also be used in leukemia and
other diseases, which shows that VK2 still has great development potential. As a new adjuvant drug, VK2
has attracted worldwide attention and has been used in the clinic for many years. In this article, we mainly
summarized the related research of VK2 in recent years, and expounded on several VK2-related signal
pathways and the related mechanisms of these signal pathways in treating various diseases.
Intrascrotal Extratesticular Schwannoma: A Rare Cause of Scrotal Mass
Authors: Aslan Serdar , Eryuruk Uluhan , Ogreden Ercan , Tasdemir Merve Nur , Cınar Ilkay , Bekci Tumay 
Published: September 2022

Background:
Schwannoma, also known as neurinoma, is the most common tumor of the peripheral nerves. Intrascrotal extratesticular schwannoma, which is not associated with schwannomatosis and neurofibromatosis-2, is a very rare entity and few cases have been reported in the literature. In this paper, we reported our case of extratesticular schwannoma, an extremely rare cause of scrotal mass, with ultrasound (US) and magnetic resonance imaging (MRI) findings.

Case Report:
A 22-year-old male presented with painless left scrotal swelling. Scrotal US showed an extra-testicular heterogeneous hypoechoic mass with lobulated contour in inferior part of scrotum. Scrotal MRI demonstrated well-defined extratesticular mass, which showed heterogeneous hypointens on T2 weighted-images compared with testis parenchyma. On contrast enhanced images, mass showed mild-modarate enhancement. The patient was underwent to surgery with the preliminary diagnosis of benign intrascrotal extratesticular mass. The lesion was removed with preservation of the testicles by urologists, and final diagnosis was made as scrotal schwannoma by histological and immunohistochemical examination

Conclusion:
Although there is no specific imaging finding of scrotal schwannoma, MRI can be used as a guide to surgery by helping to accurately determine whether the lesion is intra- or extratesticular. In addition, radiologists and urologists should keep schwannoma in mind in the differential diagnosis in the presence of an intrascrotal extratesticular mass.
First Report on the Antimicrobial, Antioxidant, Antihemolytic and
Antiinflammatory Activities of Extracts of Two Apiaceous Species from
Eastern Algeria
Authors: Elkolli Meriem , Elkolli Hayat , Laouer Hocine 
Published: September 2022

Background:
Plants continue to be widely used in Algeria to treat many health disorders;
hence, there is a need to find new natural substances of plant origin with effective biological
properties.

Objective:
The aim of this study was to investigate the bioactivity of two apiaceous species, Daucus
gracilis and Carum montanum, growing in Algeria in order to find new uses of local plants that
can replace expensive and inaccessible medicines by local people.

Methods:
The methanolic extracts (MEs) were prepared in water/methanol solvent. Afterwards, an
estimation of total phenolic content (TPC) was made. The MEs were tested for their antimicrobial
activities by the disc diffusion test; the antioxidant activity of the MEs alone and their combinations
was tested using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) and the reducing power tests. The
antihemolytic effect was tested by the stabilization of the human red blood cell (HRBC) membrane
method, and the in vitro antiinflammatory activity was evaluated by the protein denaturation method.

Results:
The MEs were found to be high in TP with 149.05 μg/mg in D. gracilis and 101.50 μg/mg in C. montanum. The best antimicrobial activity recorded with B. cereus (9.5mm) was lower than that of gentamicin (GM: 10μg) at 19-20 mm. The MEs exhibited the highest antioxidant activity (IC50=60.09 μg/ml for D. gracilis, 65.04 μg/ml for C. montanum) and reducing power effect, which was strongly concentration-dependent. The extract of D. gracilis exhibited important membrane stabilization, and the inhibition of denaturation was directly related to the concentration; Carum extract was found to be active with an IC50 value of 298.12μg/ml and Daucus with an IC50 value of 554.07μg/ml.

Conclusion:
It can be concluded that these two species can be used for food preservation and in
herbal medicine after additional toxicity and molecular characterization studies.
Non-Alcoholic Fatty Pancreas Disease: The Unsung Disease
Authors: Sevim Burak C. , Chela Harleen , Ertugrul Hamza , Malik Lyiba S. , Malik Suha , Basar Omer , Daglilar Ebubekir , Samiullah Sami , Gaballah Ayman H. , Tahan Veysel 
Published: September 2022

Abstract:
Non-alcoholic fatty pancreas disease (NAFPD) is a relatively new and emerging disease definition that is increasingly diagnosed every year, like non-alcoholic fatty liver disease (NAFLD). It is associated especially with metabolic syndrome and obesity. As awareness of pancreatic steatosis and its clinical implications increase, it is diagnosed more frequently. The researchers have explained the clinical importance of NAFPD and the diseases it causes, such as pancreatitis, pancreatic insufficiency, and pancreatic cancer. Although the definitive treatment is not yet established, the primary treatment approach is weight loss since NAFPD is associated with metabolic syndrome as well as obesity. Although pharmacological agents such as oral hypoglycemic agents have been investigated in animal experiments, studies on humans have not been conducted. Since the research on NAFPD is still insufficient, it is a subject that needs to be investigated, and further studies are needed to explore its pathophysiology, clinical impact and its management.
Causes of Variation Orders in Road Construction Projects in Tanzania
Authors: Saki Roziana , Yeom Chunho 
Published: September 2022

Background:
Variation order has long been an essential component of road construction projects worldwide, being predominantly observed in Tanzania, where road projects are particularly vulnerable.

Objective:
This study aimed to determine the sources of variation orders in Tanzanian road construction projects and provide a feasible remedy, such as reduction or eradication.

Methods:
A desk study and questionnaire were utilized as the research approach and analyzed using the relative importance index (RII) method.

Results and Discussion:
The results reveal that the most significant circumstances causing variation orders are financial problems, weather conditions, differing site conditions, changes in design, poor scheduling, lack of coordination, delay in approval, unavailability of equipment, and lack of communication.

Conclusion:
Recommended strategies to minimize variation orders were that all involved parties should plan before the commencement of on-site work and perform detailed site investigations. Consultants should ensure that the design and specifications are within the approved budget. All participants were required to spend adequate time in the pretender planning phase. Finally, accurate information and research should be obtained regarding procurement procedures, materials, and plants.
HPLC Fingerprint Analysis Coupled with Multivariate Analysis for Quality
Assessment of Picrorhiza kurroa Rhizomes
Authors: Patel Nikunj Dhirubhai , Patel Rinkal N. , Vegad Kunjal L. , Kanaki Niranjan S. 
Published: September 2022

Background:
Kutki, the dried rhizome of Picrorhiza kurroa Royle ex Benth belonging to the family of Scrophulariaceae, has been utilized globally for liver ailments.

Objective:
Comprehensive use of kutki needs to evaluate its role as a quality control tool for dis-crimination of kutki samples, and therefore an effective HPLC fingerprinting method was estab-lished.

Methods:
Reverse-phase high-performance liquid chromatography with photodiode array (RP-HPLC-PDA) detection method coupled with multivariate analysis was developed, which was mod-est, consistent and, accurate for classification of 11 kutki samples including authentic Picrorhiza kurroa rhizomes from the market of Ahmedabad and Gandhinagar in Gujarat, India.

Results:
The method was validated for various parameters like precision, reproducibility, and stabil-ity. The lowest value of the % relative standard deviations (RSD) was 1.31%. Chromatographic fin-gerprint profiles of 11 kutki samples, including authenticated samples, were obtained by this meth-od, which showed a total of 28 peaks, and 9 peaks were important among them. Chemometric tech-niques like PCA and HCA were applied to identify the kutki samples.The Samples of kutki could be exquisitely differentiated into two clusters.

Conclusion:
HPLC-PDA method coupled with multivariate analysis divulged that chromatographic fingerprint analysis was reliable and effective for quality assessment and discrimination of kutki samples.
ONE-DIMENSIONAL BIOLOGICAL MODEL OF SYNOVIAL JOINTS REGENERATIVE REHABILITATION IN OSTEOARTHRITIS
Authors: Popov Valentin L. , Poliakov Aleksandr , Pakhaliuk Vladimir 
Published: September 2022

This work is devoted to the study of a one-dimensional phenomenological model of a focal defect regenerative rehabilitation in the articular cartilage. The model is based on six differential equations in partial derivatives of the “Diffusion-Reaction” type, which was previously used by a number of authors to study cellular processes in various tissues under cell therapy conditions. To take into account the influence of moderate mechanical stimulation of immature tissue, an indirect approach was used, as a result of which some model parameters that directly affect cell proliferation and differentiation were varied considering experimental data. The results of the model study show that moderate stimulation of immature tissue in the early stages of repair the focal articular cartilage defect under conditions of cell therapy leads to an intensification of regenerative processes in the tissue and promotes more rapid formation of the extracellular matrix.
Contra o Presidencialismo e a Representação Profissional
Authors: Paiva Julius Victorius Diógenes , Cabral Rafael Lamera Giesta 
Published: September 2022

The Brazilian legislative power was absent during the Provisional Government (1930 - 1934). While Getúlio Vargas concentrated powers, important political actors were relegated to regional isolation. However, the jurist and politician José Augusto from Rio Grande do Norte, who had been removed from the position of Senator of the Republic, kept his engagement in crucial political activities in the press in Rio de Janeiro. The paper aims to analyze how his political performance evolved in the period of the Provisional Government of Getúlio Vargas, using as primary source journalistic documents and the articles he published in the newspapers Diário de Notícias and O Jornal. In the process, we take into account the context in which the political ideas at the time were embedded. José Augusto’s standpoint was then moving towards a defense of parliamentarism and political representation based exclusively on universal suffrage, in contrast to the political movements of Vargas’ support base, which was firmly committed to presidentialism (with centralization of power) and class representation as a revolutionary alternative at a time when the country was preparing to draft its new Constitution.
PENGEMBANGAN CD INTERAKTIF UNTUK MEDIA PEMBELAJARAN MATA KULIAH GRADING JURUSAN BUSANA UNIVERSITAS NEGERI PADANG
Authors: Nelmira Weni 
Published: September 2022

Penelitian ini bertujuan mengembangkan dan menghasilkan produk berupa CD Interaktif pembelajaran Grading dalam bentuk compact disk (CD Interaktif). Penelitian ini merupakan penelitian pengembangan yaitu Research and Development (R & D) dengan desain penelitian pengembangan yang digunakan yaitu model four D (4-D models), terdiri dari tahap pendefenisian (define), perencanaan (design), pengembangan (develop) dan penyebaran (disseminate). Teknik analisis yang digunakan adalah teknik analisis deskriptif. Prosedur pengembangan produk mencakup uji validasi, uji praktikalitas dan uji efektifitas. Hasil uji validasi media CD Interaktif yang dinilai oleh validator dengan tiga kriteria yaitu syarat didaktik, syarat konstruksi dan syarat teknis dengan rata-rata 93 % dengan kategori sangat valid. Berdasarkan uji validitas, maka media CD Interaktif Grading ini telah valid dan dapat digunakan. Praktikalitas media CD Interaktif oleh mahasiswa dinilai sangat praktis (94,58 %). Jadi media CD Interaktif mudah digunakan, menarik, jelas dan menimbulkan minat pada pembelajaran Grading. Efektivitas media CD Interaktif dapat dinilai sangat efektif dimana terjadi peningkatan hasil belajar mahasiswa sebanyak 17,69%. Hal ini menunjukkan bahwa pembelajaran Grading dengan menggunakan media CD Interaktif dapat membantu memaksimalkan proses dan hasil belajar sesuai dengan tujuan yang diharapkan.
MENINGKATKAN AKTIVITAS DAN HASIL BELAJAR SISWA PADA MATA PELAJARAN TEKNOLOGI INFORMASI DAN KOMUNIKASI DI SMP NEGERI 7 PADANG
Authors: Arman Arman 
Published: September 2022

The purpose of this class action research to find out the application of the method of learning Flashcard learning outcomes against grade VIII.I SMP Negeri Padang in 7 subjects, information and communication technology. Flashcard is one method of learning in the form of presentation of the learning material through the image. These image is a series of messages was presented with information on each painting that is written on the back. The research method used the class Act (Classroom Action Research) with the analysis of the percentage against the result of learning. This research was conducted as many as three cycle with many meetings each cycle is two times. The results showed that Flascard learning methods can increase the activity and results of student learning. The average student learning activities at each cycle.
PERANGKAT PEMBELAJARAN FISIKA BERBASIS MODEL PEMBELAJARAN PROBLEM BASED LEARNING (PBL) DENGAN PENDEKATAN GUIDE INQUIRY PADA MATERI FLUIDA DINAMIS TERINTEGRASI BENCANA ANGIN TOPAN
Authors: Riyaningtyas Retno , Yulkifli Yulkifli , Fauzi Ahmad 
Published: September 2022

This research is motivated importance of community preparedness to face the threat of hurricanes. This research aims to develop devices based learning high school physics teaching model of problem based learning with guided inquiry approach to the material dynamically integrated fluid cyclone with valid criteria, practical and effective. This type of research is a research-development using a model 4-D comprising the steps define, design, develop and dessiminate. In the define phase-end preliminary analysis, the analysis of the students, the task analysis, material analysis and the analysis of learning goals. At the design stage to do the preparation beracuan test criteria, the selection of media, format selection and initial design learning device. On Stage develop expert assessment (validation) and test development (practicalities and effectiveness) learning device. Data were analyzed using descriptive percentages. Results of the research is already successfully developed a learning tool in the form of high school physics syllabus, lesson plans, modules and assessments on integrated dynamic fluid material cyclone with very valid category with a percentage of 94.52%, very practical with a percentage of 88.91% and effectively with the percentage of 78 , 52%.
Gambaran Pelaksanaan Praktek Pelatihan Tata Boga di UPTD Balai Latihan Kerja (BLK) Kabupaten Sijunjung
Authors: Azzuhra Andiny Putri , Setiawati Setiawati 
Published: September 2022

The research was distributed by implementation of training practices attended by trainess at UPTD Balai Latihan Kerja. The purpose of this research to know : (1) description of implementation of culinary training in opening activities, (2) description of implementation of culinary training in the main activities, (3) description of implementation of culinary training in closing activities. This study uses a quantitative approach with a descriptive type. This research was carried at UPTD Balai Latihan Kerja Kabupaten Sjijunjung. The population in this study were 20 people, the entire population in this study became respondents. Techniques with data collection tools are using questionnaires and analysis of percentage calculation data. The results of this study indicate that (1) implementation of cooking practies in the opening activities is good, (2) implementation of cooking practies in the main activities is good,(3) implementation of cooking practies in the closing activities is good. The conclusion of this study is that the implementation of culinary practices has been good. Suggestions for this study training participants to be able to increase knowledge, skills and instructors are able to deliver material to tarinees.