bluuebunny/crossref_metadata_2025_split huggingface dataset:
Age-Related Differences in the Perception of Robotic Referential Gaze in Human-Robot Interaction
Authors: Morillo-Mendez Lucas , Schrooten Martien G. S. , Loutfi Amy , Mozos Oscar Martinez 
Published: September 2022

Abstract
There is an increased interest in using social robots to assist older adults during their daily life activities. As social robots are designed to interact with older users, it becomes relevant to study these interactions under the lens of social cognition. Gaze following, the social ability to infer where other people are looking at, deteriorates with older age. Therefore, the referential gaze from robots might not be an effective social cue to indicate spatial locations to older users. In this study, we explored the performance of older adults, middle-aged adults, and younger controls in a task assisted by the referential gaze of a Pepper robot. We examined age-related differences in task performance, and in self-reported social perception of the robot. Our main findings show that referential gaze from a robot benefited task performance, although the magnitude of this facilitation was lower for older participants. Moreover, perceived anthropomorphism of the robot varied less as a result of its referential gaze in older adults. This research supports that social robots, even if limited in their gazing capabilities, can be effectively perceived as social entities. Additionally, this research suggests that robotic social cues, usually validated with young participants, might be less optimal signs for older adults.
Isotopic reconstruction of the subsistence strategy for a Central Italian Bronze Age community (Pastena cave, 2nd millennium BCE)
Authors: Cortese Francesca , De Angelis Flavio , Achino Katia Francesca , Bontempo Luana , di Cicco Maria Rosa , Gatta Maurizio , Lubritto Carmine , Salari Leonardo , Silvestri Letizia , Rickards Olga , Rolfo Mario Federico 
Published: September 2022

AbstractThe Pastena cave is located in central Italy, and its best-preserved sector is Grotticella W2, which is dated radiometrically to the Early-Middle Bronze Age. The aim of this paper is to explore human diet, animal husbandry, and plant management, analysing the findings there discovered. Carbon and nitrogen stable isotope analysis was carried out on 40 charred seeds, six faunal remains, and four human individuals, investigating the whole bio-archaeological material available. To the best of our knowledge, this is one of the first papers presenting stable isotope analysis on carpological remains dated to the Italian Early-Middle Bronze Age. The obtained results are consistent with a diet based on terrestrial protein, mainly on plants, and secondly on animal products. The data suggest that plants, especially broad beans, were partially subjected to human management, while livestock was managed through different husbandry strategies. The cooperation between archaeological studies and molecular analysis allows us to contribute to clarifying the economic strategies for a Central Italian community in a scenario that is still poor in published data.
Exploration of biomarkers for the diagnosis, treatment and prognosis of cervical cancer: a review
Authors: Arip Masita , Tan Lee Fang , Jayaraj Rama , Abdullah Maha , Rajagopal Mogana , Selvaraja Malarvili 
Published: September 2022

AbstractAs the fourth most diagnosed cancer, cervical cancer (CC) is one of the major causes of cancer-related mortality affecting females globally, particularly when diagnosed at advanced stage. Discoveries of CC biomarkers pave the road to precision medicine for better patient outcomes. High throughput omics technologies, characterized by big data production further accelerate the process. To date, various CC biomarkers have been discovered through the advancement in technologies. Despite, very few have successfully translated into clinical practice due to the paucity of validation through large scale clinical studies. While vast amounts of data are generated by the omics technologies, challenges arise in identifying the clinically relevant data for translational research as analyses of single-level omics approaches rarely provide causal relations. Integrative multi-omics approaches across different levels of cellular function enable better comprehension of the fundamental biology of CC by highlighting the interrelationships of the involved biomolecules and their function, aiding in identification of novel integrated biomarker profile for precision medicine. Establishment of a worldwide Early Detection Research Network (EDRN) system helps accelerating the pace of biomarker translation. To fill the research gap, we review the recent research progress on CC biomarker development from the application of high throughput omics technologies with sections covering genomics, transcriptomics, proteomics, and metabolomics.
Distributional Validation of Precipitation Data Products with Spatially Varying Mixture Models
Authors: Warr Lynsie R. , Heaton Matthew J. , Christensen William F. , White Philip A. , Rupper Summer B. 
Published: September 2022

AbstractThe high mountain regions of Asia contain more glacial ice than anywhere on the planet outside of the polar regions. Because of the large population living in the Indus watershed region who are reliant on melt from these glaciers for fresh water, understanding the factors that affect glacial melt along with the impacts of climate change on the region is important for managing these natural resources. While there are multiple climate data products (e.g., reanalysis and global climate models) available to study the impact of climate change on this region, each product will have a different amount of skill in projecting a given climate variable, such as precipitation. In this research, we develop a spatially varying mixture model to compare the distribution of precipitation in the High Mountain Asia region as produced by climate models with the corresponding distribution from in situ observations from the Asian Precipitation—Highly Resolved Observational Data Integration Towards Evaluation (APHRODITE) data product. Parameter estimation is carried out via a computationally efficient Markov chain Monte Carlo algorithm. Each of the estimated climate distributions from each climate data product is then validated against APHRODITE using a spatially varying Kullback–Leibler divergence measure. Supplementary materials accompanying this paper appear online.
Myxolipoma of hand in a child: case report of a rare tumor
Authors: Deka Jeena Bordoloi , Shah Mohit Veer Kumar , Shah Ritu , Bhatnagar Nidhi , Bortolotto Chandra , Jiménez Fernando 
Published: September 2022

AbstractLipomatous tumors account for less than 10% of tumors in the pediatric population. Myxolipomas (a subset of lipoma characterised by mature adipose tissue and abundant mucoid substance) are found to be even rarer. There are a few case reports in different body parts like heart, kidney, oral cavity, epiglottis, cervical and mediastinal regions. However, there are no case reports on the involvement of the hands in any age group. High resolution ultrasound is the imaging modality of choice for the initial evaluation of superficial soft tissue tumors, their site, nature and extent. In conjunction with clinical findings and age of presentation, it helps in narrowing down the differential diagnosis and planning the management. Hyperechoic fatty tumors in the pediatric hand are mostly benign and includes lipomas, lipoblastomas and fibrous hamartomas of infancy as the main differentials. A definitive diagnosis is based on a histo-pathological and molecular cytogenetic examination. This article presents a never before reported case of a rare, large, myxolipoma of the hand in a 22-month-old boy.
Clinical characteristics and outcomes of a patient population with atypical hemolytic uremic syndrome and malignant hypertension: analysis from the Global aHUS registry
Authors: Halimi Jean-Michel , Al-Dakkak Imad , Anokhina Katerina , Ardissino Gianluigi , Licht Christoph , Lim Wai H. , Massart Annick , Schaefer Franz , Walle Johan Vande , Rondeau Eric 
Published: September 2022

AbstractIntroductionAtypical hemolytic uremic syndrome (aHUS) is a rare form of thrombotic microangiopathy (TMA) often caused by alternative complement dysregulation. Patients with aHUS can present with malignant hypertension (MHT), which may also cause TMA.MethodsThis analysis of the Global aHUS Registry (NCT01522183) assessed demographics and clinical characteristics in eculizumab-treated and not-treated patients with aHUS, with (n = 71) and without (n = 1026) malignant hypertension, to further elucidate the potential relationship between aHUS and malignant hypertension.ResultsWhile demographics were similar, patients with aHUS + malignant hypertension had an increased need for renal replacement therapy, including kidney transplantation (47% vs 32%), and more pathogenic variants/anti-complement factor H antibodies (56% vs 37%) than those without malignant hypertension. Not-treated patients with malignant hypertension had the highest incidence of variants/antibodies (65%) and a greater need for kidney transplantation than treated patients with malignant hypertension (65% vs none). In a multivariate analysis, the risk of end-stage kidney disease or death was similar between not-treated patients irrespective of malignant hypertension and was significantly reduced in treated vs not-treated patients with aHUS + malignant hypertension (adjusted HR (95% CI), 0.11 [0.01–0.87],P = 0.036).ConclusionsThese results confirm the high severity and poor prognosis of untreated aHUS and suggest that eculizumab is effective in patients with aHUS ± malignant hypertension. Furthermore, these data highlight the importance of accurate, timely diagnosis and treatment in these populations and support consideration of aHUS in patients with malignant hypertension and TMA.Trial registration detailsAtypical Hemolytic-Uremic Syndrome (aHUS) Registry.Registry number: NCT01522183 (first listed 31st January, 2012; start date 30th April, 2012).Graphical abstract
Asymptotics for the twisted eta-product and applications to sign changes in partitions
Authors: Bridges Walter , Franke Johann , Garnowski Taylor 
Published: September 2022

AbstractWe prove asymptotic formulas for the complex coefficients of $$(\zeta q;q)_\infty ^{-1}$$

(
ζ
q
;
q
)

∞

-
1

, where $$\zeta $$
ζ
is a root of unity, and apply our results to determine secondary terms in the asymptotics for p(a, b, n), the number of integer partitions of n with number of parts congruent a modulo b. Our results imply that, as $$n \rightarrow \infty $$

n
→
∞

, the difference $$p(a_1,b,n)-p(a_2,b,n)$$

p

(

a
1

,
b
,
n
)

-
p

(

a
2

,
b
,
n
)

for $$a_1 \ne a_2$$

a
1

≠

a
2

oscillates like a cosine when renormalized by elementary functions. Moreover, we give asymptotic formulas for arbitrary linear combinations of $$\{p(a,b,n)\}_{1 \le a \le b}.$$

{
p

(
a
,
b
,
n
)

}

1
≤
a
≤
b

.
Occupational risk assessment based on employees’ knowledge and awareness of hazards in mining
Authors: Patyk Michał , Nowak-Senderowska Dagmara 
Published: September 2022

AbstractAnalyses and assessments of hazards occurring in work processes are carried out by teams, in which there is usually one representative of the personnel, as the embodiment of the active participation of employees in the assessment of occupational risks. This is why the article presents research on all employees’ knowledge and awareness about risks in their work environment. The research was carried out in the form of an employee survey in one of the open-pit mines, at workstations dealing with the loading and transporting of excavated material. The survey included a list of 40 hazards divided into four groups: (1) hazards related to machines and equipment used, (2) hazards related to exposure, (3) hazards with an impact extending beyond the workstation and (4) hazards of an ergonomic nuisance nature, where employees were required to indicate which hazards apply to their workplaces and determine their level of significance, probability of occurrence and the scale of possible effects. In this way, a hierarchical identification of threats occurring at the analyzed workplaces was made, and the obtained results were used to determine the amount of occupational risk both for specific workstations and for the whole technological process. The measures of the magnitude of occupational risk obtained using the proposed method have showed that, according to the respondents, greatest risks at the workstation are associated with moving machines and vehicles and with mobile equipment. Equally important risks, which were often mentioned by employees, were those directly related to their health, i.e., related to ergonomic nuisance and exposure. Threats resulting from geological and mining conditions, considered typical for mining, were important for the surveyed miners but they were not the most important owing to proper prevention, good organization of work and high safety culture The active involvement of the crew in the process of assessing occupational hazards allowed to identify the significance of each hazard, in the opinion of the personnel working at various places and to use this ranking for determining occupational risk levels in the mining company concerned. The research has also outlined another goal to be achieved: a comparison of the relative significance of hazards identified by the employees and of the hazards listed in occupational risk assessment matrices used by mines.
Loss of disability-adjusted life years due to heat-related sleep disturbance in the Japanese
Authors: Ihara Tomohiko , Narumi Daisuke , Fukuda Sanae , Kondo Hiroaki , Genchi Yutaka 
Published: September 2022

AbstractThe purpose of this study was to quantify the sleep disturbances caused by climate change using disability-adjusted life years (DALY). The revised sleep quality index for daily sleep (SQIDS2), a self-administered questionnaire for daily sleep quality, was developed to assess daily sleep disturbances. This questionnaire referenced and simplified the Pittsburgh Sleep Quality Index (PSQI). This study was conducted in Nagoya City in August 2011 and 2012. Sleep quality was measured using SQIDS2 and PSQI. A total of 574 participants in 2011 and 710 in 2012 responded to the survey. The sleep disturbance prevalence calculated from the SQIDS2 score was correlated with the daily minimum temperature (p = 0.0067). This score increased when the daily minimum temperature was above 24.8 °C. When correcting for the PSQI score, DALY loss due to heat-related sleep disturbances in Nagoya City (population: 2,266,851) was estimated to be 81.8 years in 2012. This value was comparable to the DALY loss due to heatstroke. Sleep disturbance due to climate change was quantified using the DALY based on the PSQI. Legislators must recognize the critical impact of the damage caused by sleep disturbances due to high temperatures at night. Additionally, a daily minimum temperature of 25 °C should be the starting point when establishing a goal or guideline for nighttime temperature.
Extended High‐Frequency Ototoxicity Induced by the First Administration of Cisplatin
Authors: Sakamoto Masayuki , Kaga Kimitaka , Kamio Tomokazu 
Published: September 2022

The ototoxicity induced by cisplatin results in high‐frequency hearing loss. The sound‐pressure thresholds at extended high frequencies of 8 to 20 kHz were measured in 12 patients with head and neck cancer before and after the first administration of cisplatin. Ototoxicity was defined statistically by the newly introduced regression‐line analysis. This analysis revealed that the threshold of 1 of the 12 patients increased evenly from 8 to 10 kHz, and the damage to the hearing system of this patient was permanent. The reasons for such a low rate of ototoxicity might be the long‐term administration of low doses of cisplatin and the addition of fosfomycin.
Oxygenation of Advanced Head and Neck Cancer: Prognostic Marker for the Response to Primary Radiochemotherapy
Authors: Vanselow Bernhard , Eble Michael J. , Rudat Volker , Wollensack Petra , Conradt Christian , Dietz Andreas 
Published: September 2022

Recent clinical studies suggest that the degree of tumor oxygenation may be predictive of the response of radiation therapy for cancer. In an exploratory investigation of cervical lymph node metastases in 27 patients with advanced squamous cell carcinoma of the oropharynx and hypopharynx, this relationship was investigated by means of oxygen measurements with an Eppendorf Po2 histograph. The measurements were made before the start of radiation therapy and after the first week of therapy. Clinical response was evaluated 6 weeks after the completion of therapy. Before therapy, marked hypoxia was observed in the lymph node metastases, with a mean Po2 value of 16.1 ± 8.2 mm Hg and a hypoxic fraction (Po2 < 10 mm Hg) of 56.4% ± 20.0%. After the first week of radiation (9 Gy) there was a general reoxygenation (ΔPo2 = 5.0 ± 10.1 mm Hg, P < 0.05; Δhypoxic fraction = −11.3% ± 31.3%, P = 0.11). A relationship between the degree of reoxygenation and tumor response was not observed. Patients without at least partial lymph node response (n = 8) showed poorer pretherapeutic oxygenation (Po2 mean = 11.1 ± 2.9 mm Hg) than those who responded to the therapy (n = 19, PO2 mean = 18.2 ± 8.8 mm Hg). In this investigation of a defined set of patients with advanced carcinoma of the oropharynx and hypopharynx, we found that pretherapeutic oxygenation data are predictive for the therapeutic response to radiation therapy or radiochemotherapy.
Facial Nerve Stimulation and Postparotidectomy Facial Paresis
Authors: Reilly Jacquelyn , Myssiorek David 
Published: September 2022

OBJECTIVEWe sought to evaluate the association of intraoperative facial nerve stimulation and postoperative facial nerve paresis/paralysis.STUDY DESIGN AND SETTINGEighty‐nine consecutive patients who underwent parotidectomy by a single surgeon were retrospectively analyzed for age, gender, size of tumor, tumor histology, and intraoperative use of a facial nerve stimulator.RESULTSFacial paresis developed in 22% (10 of 46) of the patients who were stimulated and 22% (5 of 23) of the nonstimulated patients. These results were not statistically significant (P = 1.0000). There was no permanent paralysis in either group. The tumor type and size and gender and age of the patient did not affect the outcome.CONCLUSIONThere was no difference in the incidence of postoperative facial nerve paresis or paralysis between the stimulated and nonstimulated patients. Routine use of a stimulator is not necessary during parotid surgery because its use does not prevent or promote facial nerve injury.
Follow‐up of 366 Ears after Tympanostomy Tube Insertion: Why is it Draining?
Authors: Kalcioglu M. Tayyar , Cokkeser Yasar , Kizilay Ahmet , Ozturan Orhan 
Published: September 2022

OBJECTIVETympanostomy tube insertion is one of the most frequently performed procedures in otolaryngology. Complications, such as otorrhea, tympanosclerosis, and cholesteatoma, have been reported in the literature after its application.STUDY DESIGNThis study reports the complications encountered with 239 children (439 ears) with a follow‐up of 7 to 73 months (median, 29 months) after tympanostomy tube insertion. Hearing results and middle ear pressures were compared and complications were noted in 366 ears that were available for the study.RESULTSOtorrhea developed in 3 (0.8%) cases. Tympanosclerosis was seen in 74 (20.2%) cases. Tympanic membrane perforation, retraction pocket, granulation tissue, and atelectasis were seen in 4.6%, 5.2%, 1.1%, and 6%, respectively. No patients developed cholesteatoma after tube insertion. Hearing results were improved postoperatively in 93.4% of patients (median, 14.2 dB) and worse in 6.6% of patients (median, 8.3 dB). The average extrusion time was 7.3 months for grommet and 16.3 months for T‐tubes.CONCLUSIONMultifactor etiologies show some unsolved or misunderstood underlying pathology, or unmentioned environmental factor such as atopy due to rich flora and humidity might exist to consider in the pathophysiology of the otorrhea.
Minimally Invasive Laser Contraction Myringoplasty for Tympanic Membrane Atelectasis*
Authors: Ostrowski Vincent B. , Bojrab Dennis I. 
Published: September 2022

OBJECTIVEWe sought to develop a minimally invasive surgical technique using the CO2 laser to reduce or eliminate tympanic membrane atelectasis in a select group of patients.STUDY DESIGNThirty‐seven ears with varying degrees of tympanic membrane atelectasis underwent CO2 laser myringoplasty with the patients under intravenous sedation in the operating room setting. Atelectasis severity was graded for each patient and documented before and after laser myringoplasty through photodocumentation. Patients were followed for 1 year with comparison tympanic membrane photography.SETTINGThe study was conducted in a tertiary care private otology‐neurotology practice.RESULTSLaser myringoplasty significantly reduced retraction pocket severity in most patients. No patients required resection of the retraction pocket or tympanoplasty. The most favorable outcomes were observed in patients with atelectasis addressed early rather than later in its more advanced stages.CONCLUSIONLaser contraction myringoplasty can reduce or eliminate atelectatic areas of the tympanic membrane through immediate contraction and “tightening” of the tympanic membrane tissues. Clinicians should use a standardized tympanic membrane atelectasis grading format.SIGNIFICANCEA minimally invasive surgical technique for addressing tympanic membrane atelectasis is described, and a tympanic membrane at‐electasis grading system is presented based on size, location, and depth of the atelectatic region.
A Randomized Trial of Temperature‐Controlled Radiofrequency, Continuous Positive Airway Pressure, and Placebo for Obstructive Sleep Apnea Syndrome
Authors: Woodson B. Tucker , Steward David L. , Weaver Edward M. , Javaheri Shahrokh 
Published: September 2022

OBJECTIVEThe study goal was to determine the effectiveness of (1) multilevel temperature‐controlled radiofrequency tissue ablation (TCRFTA) or (2) continuous positive airway pressure (CPAP) for the treatment of mild to moderate obstructive sleep apnea syndrome (OSAS).STUDY DESIGN AND METHODSWe conducted a randomized, placebo‐controlled, 2‐site trial, comparing TCRFTA (n=30) and CPAP (n=30) with sham‐placebo (n=30) using intention‐to‐treat analysis.RESULTSCompared with pretreatment baseline, TCRFTA improved reaction time, OSAS‐specific quality of life (QOL), and subjective sleepiness (all P < 0.05). Compared with sham‐placebo, TCRFTA improved QOL, airway volume, apnea index, and respiratory arousal index (all P < 0.05). TCRFTA side effects and complications were mild, temporary, and similar to sham‐placebo. CPAP improved QOL and sleepiness compared with baseline and QOL when compared with sham‐placebo (all P < 0.05). Significant differences were not seen between TCRFTA and CPAP outcomes.CONCLUSIONTCRFTA and CPAP each improve QOL for mild‐moderate OSAS patients. TCRFTA improvements may result from changes in airway volume, apnea index, and respiratory arousal index.