bluuebunny/crossref_metadata_2025_split huggingface dataset:
Potential association with malnutrition and allocation of combination medical therapies in hospitalized heart failure patients with reduced ejection fraction
Authors: Kawakubo Yumiko , Shiraishi Yasuyuki , Kohsaka Shun , Kohno Takashi , Goda Ayumi , Nagatomo Yuji , Nishihata Yosuke , Saji Mike , Takei Makoto , Ikegami Yukinori , Niimi Nozomi , Sandhu Alexander Tarlochan Singh , Nakano Shintaro , Yoshikawa Tsutomu , Fukuda Keiichi ,   West Tokyo Heart Failure Registry, Shiraishi Yasuyuki , Kohsaka Shun , Kohno Takashi , Goda Ayumi , Nagatomo Yuji , Nishihata Yosuke , Saji Mike , Takei Makoto , Ikegami Yukinori , Nakano Shintaro , Yoshikawa Tsutomu 
Published: May 2022

AbstractMalnutrition is common in patients with heart failure with reduced ejection fraction (HFrEF) and may influence the long-term prognosis and allocation of combination medical therapy. We reviewed 1231 consecutive patient-level records from a multicenter Japanese registry of hospitalized HFrEF patients. Nutritional status was assessed using geriatric nutritional risk index (GNRI). Combination medical therapy were categorized based on the use of beta-blockers, renin-angiotensin system inhibitors, and mineralocorticoid receptor antagonists. The composite outcome of all-cause death and HF rehospitalization was assessed. The mean age was 72.0 ± 14.2 years and 42.6% patients were malnourished (GNRI < 92). At discharge, 43.6% and 33.4% of patients were receiving two and three agents, respectively. Malnourished patients had lower rates of combination medical therapy use. The standardized GNRI score was independently associated with the occurrence of adverse events (hazard ratio [HR]: 0.88, 95% confidence interval [CI] 0.79–0.98). Regardless of the GNRI score, referenced to patients receiving single agent, risk of adverse events were lower with those receiving three (HR: 0.70, 95% CI 0.55–0.91) or two agents (HR: 0.70, 95% CI 0.56–0.89). Malnutrition assessed by GNRI score predicts long-term adverse outcomes among hospitalized HFrEF patients. However, its prognosis may be modified with combination medical therapy.
Short and long-term effect of dexamethasone on the transcriptome profile of primary human trabecular meshwork cells in vitro
Authors: Kathirvel Kandasamy , Lester Karen , Haribalaganesh Ravinarayanan , Krishnadas Ramasamy , Muthukkaruppan Veerappan , Lane Brian , Simpson David A. , Goljanek-Whysall Kasia , Sheridan Carl , Bharanidharan Devarajan , Willoughby Colin E. , Senthilkumari Srinivasan 
Published: May 2022

AbstractIn the quest of identifying newer molecular targets for the management of glucocorticoid-induced ocular hypertension (GC-OHT) and glaucoma (GCG), several microarray studies have attempted to investigate the genome-wide transcriptome profiling of primary human trabecular meshwork (TM) cells in response to dexamethasone (DEX). However, no studies are reported so far to demonstrate the temporal changes in the expression of genes in the cultured human TM cells in response to DEX treatment. Therefore, in the present study, the time-dependent changes in the genome-wide expression of genes in primary human TM cells after short (16 hours: 16 h) and long exposure (7 days: 7 d) of DEX was investigated using RNA sequencing. There were 199 (118 up-regulated; 81 down-regulated) and 525 (119 up-regulated; 406 down-regulated) DEGs in 16 h and 7 d treatment groups respectively. The unique genes identified in 16 h and 7 d treatment groups were 152 and 478 respectively. This study found a distinct gene signature and pathways between two treatment regimes. Longer exposure of DEX treatment showed a dys-regulation of Wnt and Rap1 signaling and so highlighted potential therapeutic targets for pharmacological management of GC-OHT/glaucoma.
In vitro cytotoxicity and osteogenic potential of quaternary Mg-2Zn-1Ca/X-Mn alloys for craniofacial reconstruction
Authors: Prasadh Somasundaram , Gupta Manoj , Wong Raymond 
Published: May 2022

AbstractCytotoxicity of any biomedical material needs to be investigated for successful application within the human tissues. In this study, manganese in low amounts of 0.3, 0.5 and 0.7 (wt.%) was added to Mg2Zn1Ca alloy using Disintegrated Melt Deposition (DMD) followed by hot extrusion and the extruded alloys were tested for in vitro cytocompatibility using cell viability assays (CCK-8, LDH enzyme release assay, cell cytoskeleton and cell morphology) and in vitro osteogenic potential was evaluated using ALP, Alizarin Red and RT-PCR assays. Addition of manganese improved the cell viability and osteogenic potential in variable concentrations. The Mg2Zn1Ca /0.3 Mn and Mg2Zn1Ca /0.5 Mn alloys showed increased cell viability percentage compared to Mg2Zn1Ca alloys. The cytotoxicity percentage at the end of 24 h culture for Mg2Zn1Ca /0.3 Mn alloys showed lesser cytotoxicity percentage (~ 8%) when compared to the Mg2Zn1Ca /0.5 Mn (~ 13%) and Mg2Zn1Ca /0.7 Mn (~ 16%) samples. All the alloys showed good initial cell attachment, osteogenic potential and cell spreading. The results of this study validates great potential of Mg2Zn1Ca alloys with manganese addition and exhibited great potential for to be used as temporary implant materials in craniofacial reconstruction.
Population-based study for the comorbidities and associated factors in Ménière’s disease
Authors: Kim Min Hee 
Published: May 2022

AbstractTo date, no study has reported the objective metabolic laboratory findings worldwide or the comorbidities for Ménière’s disease (MD) using a population-based design in Asian populations. The aim of this study was to investigate the comorbidities and associated factors for MD using the Korean National Health Insurance Service database. This retrospective population-based study was conducted using a data from the National Sample Cohort database from 2009 to 2015. We only enrolled patients whose records showed a prescription for MD medicine and audiometry findings as well as an appropriate diagnostic code. We also included a matched cohort without MD who were enrolled randomly and matched for sex, age, year of diagnosis, income level, and residential area with the MD group with a ratio of 10:1. We evaluated comorbidities including autoimmune, allergic, metabolic diseases and cancer and the health screening data including general characteristics (height, weight, waist circumference, body mass index, and blood pressure), laboratory findings (fasting glucose, cholesterol, triglyceride, high-density lipoproteintryglyceride (HDL) cholesterol, low-density lipoproteintryglyceride cholesterol, hemoglobin, creatinine, aspartate aminotransferase and alanine aminotransferase, and gamma-glutamyltrans- peptidase (rGT)), and general health behaviors (smoking, alcohol, and exercise) of the MD group, and compared these characteristics with those of the MD-free control group. A total of 2,013 and 20,130 participants were included in the MD and MD-free control groups (1,640 and 15,458 for health screening data). We found the increase in incidence of allergic rhinitis and allergic asthma, decrease in systolic blood pressure, HDL cholesterol, and rGT, and less frequent alcohol consumption and less prevalent smoking in the MD group. No significant differences were observed between the groups in the incidence of autoimmune diseases, and cerebro- and cardiovascular disease as well as health screening data and objective laboratory findings. Inconsistence with published studies, the results of this study suggest that the autoimmunity and metabolic disorder, and skeletal growth might not be associated with the onset of MD. Another well-designed study for other races will be needed to the generalization of this study results.
The first experience with fully endoscopic posterior cervical foraminotomy and discectomy for radiculopathy performed in Viet Duc University Hospital
Authors: Dinh Son Ngoc , Dinh Hung The 
Published: May 2022

AbstractThe aim of the article is to present the first experience of applying a full-endoscopic posterior cervical foraminotomy and discectomy performed at Viet Duc University Hospital in Hanoi and describe the outcomes of such surgical intervention. This surgical series includes 20 patients underwent surgery through full-endoscopic posterior cervical foraminotomy and discectomy. The definitive diagnosis of the patients and the evidence for surgical treatment was radiculopathy due to lateral or intraforaminal disk herniation, foraminal stenosis, and lateral recess stenosis. Patients with discogenic cervical radiculopathy but with a contraindication to endoscopic posterior cervical foraminotomy and discectomy were not subject to surgical intervention. All patients underwent a CT and MRT examination of the cervical spine before and after surgery as complementary diagnostic methods. Besides radiological diagnostic methods, electroneuromyography and spondylography were performed with functional samples, i.e., with head tilts in the front and back, to eliminate segmental instability. The timing and degree of the root pain syndrome regression were assessed using a VAS scale (visual and analog scale) with a subsequent comparison of preoperative and postoperative performance. Immediately after the operation, all patients noted a complete or nearly complete regression of the pain syndrome.
Prediction of future healthcare expenses of patients from chest radiographs using deep learning: a pilot study
Authors: Sohn Jae Ho , Chen Yixin , Lituiev Dmytro , Yang Jaewon , Ordovas Karen , Hadley Dexter , Vu Thienkhai H. , Franc Benjamin L. , Seo Youngho 
Published: May 2022

AbstractOur objective was to develop deep learning models with chest radiograph data to predict healthcare costs and classify top-50% spenders. 21,872 frontal chest radiographs were retrospectively collected from 19,524 patients with at least 1-year spending data. Among the patients, 11,003 patients had 3 years of cost data, and 1678 patients had 5 years of cost data. Model performances were measured with area under the receiver operating characteristic curve (ROC-AUC) for classification of top-50% spenders and Spearman ρ for prediction of healthcare cost. The best model predicting 1-year (N = 21,872) expenditure achieved ROC-AUC of 0.806 [95% CI 0.793–0.819] for top-50% spender classification and ρ of 0.561 [0.536–0.586] for regression. Similarly, for predicting 3-year (N = 12,395) expenditure, ROC-AUC of 0.771 [0.750–0.794] and ρ of 0.524 [0.489–0.559]; for predicting 5-year (N = 1779) expenditure ROC-AUC of 0.729 [0.667–0.729] and ρ of 0.424 [0.324–0.529]. Our deep learning model demonstrated the feasibility of predicting health care expenditure as well as classifying top 50% healthcare spenders at 1, 3, and 5 year(s), implying the feasibility of combining deep learning with information-rich imaging data to uncover hidden associations that may allude to physicians. Such a model can be a starting point of making an accurate budget in reimbursement models in healthcare industries.
Mean-field nature of synchronization stability in networks with multiple interaction layers
Authors: del Genio Charo I. , Faci-Lázaro Sergio , Gómez-Gardeñes Jesús , Boccaletti Stefano 
Published: May 2022

AbstractThe interactions between the components of many real-world systems are best modelled by networks with multiple layers. Different theories have been proposed to explain how multilayered connections affect the linear stability of synchronization in dynamical systems. However, the resulting equations are computationally expensive, and therefore difficult, if not impossible, to solve for large systems. To bridge this gap, we develop a mean-field theory of synchronization for networks with multiple interaction layers. By assuming quasi-identical layers, we obtain accurate assessments of synchronization stability that are comparable with the exact results. In fact, the accuracy of our theory remains high even for networks with very dissimilar layers, thus posing a general question about the mean-field nature of synchronization stability in multilayer networks. Moreover, the computational complexity of our approach is only quadratic in the number of nodes, thereby allowing the study of systems whose investigation was thus far precluded.
Anisotropic suppression of hyperuniformity of elastic systems in media with planar disorder
Authors: Puig Joaquín , Elías Federico , Aragón Sánchez Jazmín , Cortés Maldonado Raúl , Rumi Gonzalo , Nieva Gladys , Pedrazzini Pablo , Kolton Alejandro B. , Fasano Yanina 
Published: May 2022

AbstractDisordered hyperuniform materials with vanishing long-wavelength density fluctuations are attracting attention due to their unique physical properties. In these systems, the large-scale density fluctuations are strongly suppressed as in a perfect crystal, even though the system can be disordered like a liquid. Yet, hyperuniformity can be affected by the different types of quenched disorder unavoidably present in the host medium where constituents are nucleated. Here, we use vortex matter in superconductors as a model elastic system to study how planar correlated disorder impacts the otherwise hyperuniform structure nucleated in samples with weak point disorder. Planes of defects suppress hyperuniformity in an anisotropic fashion: while in the transverse direction to defects the long-wavelength density fluctuations are non-vanishing, in the longitudinal direction they are smaller and the system can eventually recover hyperuniformity for sufficiently thick samples. Our findings stress the need of considering the nature of disorder and thickness-dependent dimensional crossovers in the search for novel hyperuniform materials.
Cross-Sectional and Longitudinal Associations Between Quality of Parent–Child Interaction and Language Ability in Preschool-Age Children With Developmental Language Disorder
Authors: Jokihaka Suvi , Laasonen Marja , Lahti-Nuuttila Pekka , Smolander Sini , Kunnari Sari , Arkkila Eva , Pesonen Anu-Katriina , Heinonen Kati 
Published: May 2022

Purpose:
This study explores whether the quality of parent–child interaction is associated with language abilities cross-sectionally and longitudinally up to preschool-age among children with developmental language disorder (DLD).

Method:

Participants were 97 monolingual children with DLD and their parents from the Helsinki Longitudinal SLI study, HelSLI (baseline, age in years;months,
M
= 4;3,
SD
= 0;10), of which 71 pairs were followed longitudinally (age in years;months,
M
= 6;6,
SD
= 0;5). Video recordings from three play sessions were scored for child, parent, and dyadic behavior using Erickson's sensitivity scale protocol and mutually responsive orientation at baseline. Children's expressive and receptive language and language reasoning ability were assessed at baseline, and expressive and receptive language were assessed at follow-up.

Results:
At baseline, engaged child behavior, parent's supportive guidance, and fluent and attuned dyadic behavior were associated with better receptive language ability, and engaged child behavior and dyadic synchrony were positively associated with language reasoning ability in 3- to 6-year-olds. The child's positive engagement and fluent and attuned dyadic behavior at baseline were associated with better expressive and receptive language abilities at follow-up in 6- to 7-year-olds, respectively.

Conclusions:
Fluent and attuned dyadic behavior is associated with better receptive language ability in preschool-age children. Parent behavior alone was not associated with language ability. A connected and mutually attuned parent–child relationship could be a protective factor for language development for children with DLD.
Development and deployment of a digital twin for monitoring of an adaptive clamping mechanism, used for high performance composite machining
Authors: Weckx Sam , Meyers Bart , Jordens Jeroen , Robyns Steven , Baake Jonathan , Lietaert Pieter , De Geest Roeland , Maes Davy 
Published: May 2022

AbstractIn this work, we present a cloud‐based digital twin for monitoring of a clamping technology for machining of composite parts. Supporting large and/or freeform composite parts is crucial to avoid bending during drilling. Bending of the part will lead to delamination and frayed edges of the drilled holes. The new active clamping technology allows to realise a stabilised fixture, localised in the area where the drilling occurs, to avoid bending. This significantly improves the quality of the drilled holes. The clamping device is equipped with an IoT edge device, with a bidirectional communication to the cloud. The cloud‐based digital twin analyses the quality of the drilled holes based on computer vision, monitors the drill wear and detects incorrect operation of the active clamping device. All data is stored in the cloud. By means of a knowledge graph, which acquires and integrates information into an ontology and provides a central information access, it will be easier for a data scientist to query this data and to gain new insights in the operation of the drill with active clamping device. The full deployment occurs on the Microsoft Azure cloud platform. This transforms the standard machine into an Industry 4.0 compliant machine.
Prognosefaktoren bei älteren Dialysepatienten beachten
Authors: Völker Linus Alexander , Brinkkötter Paul Thomas 
Published: May 2022

ZUSAMMENFASSUNGDer Anteil betagter und hochbetagter Patienten mit terminaler Niereninsuffizienz hat aufgrund der demografischen Entwicklung und der besseren medizinischen Versorgung deutlich zugenommen. Ob jedoch die Einleitung der Dialyse mit einem Überlebensvorteil und/oder einer Verbesserung der Lebensqualität einhergehen, ist umstritten. Dies betrifft insbes. multimorbide und gebrechliche („frail”) Patienten. Zur optimalen Patienten- und Angehörigenberatung gehören deshalb Kenntnisse zu prognostisch relevanten Faktoren, um im Sinne einer partizipativen Entscheidungsfindung („shared decision making“) das Vorgehen festzulegen – sowohl im Hinblick auf die Dialysebehandlung als auch auf die Formen des konservativen Krankheitsmanagements. Die aktuell verfügbaren Prognosefaktoren entstammen zumeist retrospektiven Registerstudien und sind somit einer ausgeprägten Verzerrung („bias“) ausgesetzt. Neben dem erforderlichen nephrologischen Fachwissen ist eine altersmedizinische Expertise hilfreich, um eine optimale Versorgung der Patienten zu gewährleisten.
Phototherapeutische Keratektomie bei Salzmannʼscher nodulärer Degeneration. Welche Auswirkung hat die Wahl des Excimerlasers auf den Erfolg der
Behandlung?
Authors: Mahler Susanne Barbara Claudia , Adams Christian , Daas Loay , Langenbucher Achim , Seitz Berthold 
Published: May 2022

Zusammenfassung
Fragestellung Ziel dieser Studie war es, den Unterschied im Behandlungserfolg nach phototherapeutischer Keratektomie (PTK) bei Salzmannʼscher nodulärer Degeneration (SND) mittels
zweier Excimerlaser mit unterschiedlichen Spezifikationen zu untersuchen.
Patienten und Methoden Im Zeitraum von 2007 bis 2017 wurden 272 PTKs, die an 246 Augen mit SND von 181 Patienten durchgeführt wurden, retrospektiv untersucht. Bis 2014 wurde für die
PTK nach manueller Pannektomie der Excimerlaser MEL70 (Carl Zeiss Meditec Vertriebsgesellschaft mbH, Oberkochen, Deutschland) verwendet, danach der Amaris 750S (Schwind eye-tech-solutions
GmbH, Kleinostheim, Deutschland). Der Therapieerfolg wurde anhand folgender Parameter beurteilt: Visus, Refraktion und Astigmatismus sowie die Pachymetrie und die Endothelzellmessung zu den
Zeitpunkten T1 = präoperativ, T2 = 6-Wochen-Kontrolle, T3 = 6-Monats-Kontrolle. Zum Vergleich der Daten wurden der Wilcoxon-Mann-Whitney-U-Test und der Chi-Quadrat-Test mit einem
Signifikanzniveau von 5% genutzt.
Ergebnisse Nach 6 Monaten stieg der Visus nur in der Schwind-Gruppe signifikant um 0,17 ± 0,33 (logMAR p < 0,013). In der Zeiss-Gruppe stieg der Visus nur um 0,11 ± 0,36 (logMAR
p < 0,057). Auch für die Refraktion konnte nach 6 Monaten nur für die Schwind-Gruppe eine signifikante Änderung um 3,35 ± 2,76 dpt sphärisches Äquivalent (SEQ) (p < 0,001) gezeigt
werden. In der Zeiss-Gruppe veränderte sich das SEQ nicht signifikant (p < 0,676). Der topografische Astigmatismus verbesserte sich nach 6 Monaten in beiden Studiengruppen signifikant um
1,73 ± 1,99 dpt in der Schwind-Gruppe (p < 0,001) und um 1,99 ± 2,21 dpt in der Zeiss-Gruppe (p < 0,0001). Haze musste in der Schwind-Gruppe in 12,7% der Fälle behandelt werden und in
der Zeiss-Gruppe in 16,2% der Fälle. Eine Endothelzellschädigung zeigte sich in keiner der beiden Gruppen.
Schlussfolgerung In beiden Studiengruppen profitierten die Patienten von einer PTK bei SND. Für die Schwind-Gruppe konnte jedoch eine signifikant größere Verbesserung von Visus und
Refraktion festgestellt werden als für die Zeiss-Gruppe. Im Gegensatz zum üblichen hyperopisierenden Effekt der PTK bei anderen Diagnosen zeigte sich bei SND ein sog. „myopic shift“, der
sich aus den oft mittelperipher liegenden SND-Knoten und dem damit verbundenen asymmetrischen Tränenfilmpooling präoperativ erklären lässt.
Agonism of GPR120 Prevented High Glucose-Induced Apoptosis of Retinal Endothelial Cells through Inhibiting NLRP3 Inflammasome
Authors: Ding Xiaoju , Xie Haijuan , Shan Wuqiang , Li Ligang 
Published: May 2022

Abstract
Purpose GPR120 has been reported to ameliorate inflammation in diabetes and diabetic complications. In this study, GW9508, the GPR120 agonist, was utilized in human retinal
microvascular endothelial cells (HRMECs) exposed to high glucose (HG) to investigate the involvement of GPR120 in cellular viability and apoptosis as well as the association with the NLRP3
inflammasome.
Methods The expression of GPR120 in HRMECs cultured under HG was firstly detected by Western blotting. HRMECs were then assigned to the normal control, GW9508, HG, and HG + GW9508
groups. The expression of the NLRP3 inflammasome consists of NLRP3, ASC, and caspase-1 and was detected by Western blotting and the downstream IL-1β and IL-18 by ELISA. The cellular
viability and apoptosis of HRMECs were detected by CCK-8 and flow cytometry, respectively. The expressions of apoptosis-related proteins Bax and Bcl-2 were detected by Western blotting.
Finally, nonspecific siRNA (NS) or GPR120 siRNA (siGPR120) was transfected to the cells, followed by stimulation with or without GW9508 or HG, and the expression of NLRP3, ASC, and caspase-1
were detected by Western blotting in these groups.
Results GPR120 is expressed in HRMECs, and HG can reduce its expression in a time-dependent manner. GW9508 can attenuate inflammation by reducing the expression of NLRP3, ASC,
caspase-1, IL-1β, and IL-18 under HG. GW9508 rescues the viability of HRMCs and reduces cell apoptosis by preventing an increase in Bax expression and the reduction in Bcl-2
expression. Additionally, knockdown of GPR120 by siRNA weakened the effects of GW9508 on NLRP3 inflammasome expression.
Conclusions Activation of GPR120 protects retinal vascular endothelial cells from HG through inhibiting NLRP3 inflammasome. Thus, GPR120 might be a potential therapeutic target to
reduce retinal endothelial damage in diabetic retinopathy.