bluuebunny/crossref_metadata_2025_split huggingface dataset:
Do lower environmental, social, and governance (ESG) rated companies have higher systemic impact? Empirical evidence from Europe and the United States
Authors: Bax Karoline , Bonaccolto Giovanni , Paterlini Sandra 
Published: December 2022

AbstractIn recent years, companies have increasingly been characterized by environmental, social, and governance (ESG) scores, and investors and academics have raised questions concerning financial performance and investment risks. Now, as the European Banking Authority has acknowledged that ESG risks can potentially impact the economic and financial system, the debate on systemic risk has gained traction. Understanding the relationship between ESG merit and systemic risk is of utmost importance for the stability of the economic and financial system, still, research is limited. Relying on real‐world European and United Stated data, we quantify systemic risk by means of QL‐CoVaR. Empirical analyses of the entire period from 2007 to 2021 show that companies with high ESG scores tend to exhibit low QL‐CoVaR values indicating a positive effect of ESG scores. Such evidence is confirmed by clustering the individual companies into ESG portfolios and focusing on COVID‐19. Additional insights using the individual pillars are also provided.
Hemorrhagic gastric ulcer in a patient with Behcet's disease successfully treated with infliximab
Authors: Fujiwara Shun , Kawamoto Ami , Motobayashi Maiko , Hibiya Shuji , Takenaka Kento , Shimizu Hiromichi , Saito Eiko , Fujii Toshimitsu , Nagahori Masakazu , Kawata Daisuke , Umezawa Natsuka , Hosoya Tadashi , Yasuda Shinsuke , Ohtsuka Kazuo , Okamoto Ryuichi 
Published: December 2022

AbstractBehcet's disease (BD) is a multisystem immune‐mediated inflammatory disorder that occasionally involves the gastrointestinal tract. Reports on gastrointestinal involvement of BD are relatively rare, of which gastroduodenal involvement is particularly rare. Endoscopic features of gastroduodenal lesions are unknown, and treatment strategies have not been established. In this report, we present the case of a 72‐year‐old female with gastrointestinal BD who presented with extensive gastroduodenal ulcers and hematemesis that were resistant to colchicine and corticosteroid treatment, which were subsequently successfully treated with infliximab. We also review the current literature on the gastroduodenal involvement of BD. Although rare, the case highlights the importance of being aware of upper gastrointestinal manifestations of BD, as well as demonstrating the potential of infliximab to treat corticosteroid‐resistant cases.
Potential triggers for large earthquakes in open‐pit mines: A case study from Kuzbass, Siberia
Authors: Kocharyan Gevorg , Qi Chengzhi , Kishkina Svetlana , Kulikov Vladimir 
Published: December 2022

AbstractThe extraction and movement of rock during mining operations is considered a possible trigger for slip along the fault. In this study, possible anthropogenic causes were analyzed for triggering the earthquake with the local magnitude of ML = 6.1 (at a depth of 4 km just beneath the quarry), in the vicinity of the large coal open‐pit mine in Russia. This event was the largest earthquake associated with a quarry (an open pit). A sufficiently deep occurrence of the source testified that seismic vibrations were produced in a dynamic slip along a preexisting and prestressed tectonic fault. Analytical calculations were conducted of increments of normal and shear stresses at fault planes with several dip angles at depths corresponding to the probable location of the hypocenter of the Bachat earthquake. As the results show, long‐term rock excavations bring a prestressed thrust fault closer to the ultimate Coulomb strength, and stress variations at those depths may suffice to initiate a movement along the fault. By measuring seismic vibrations at different quarries and mines in Russia, the dynamic effect at the supposed depth of the source occurrence could be reliably estimated. As is shown, the ultimate anticipated dynamic deformations are noticeably lower than corresponding values produced by seismic waves of distant earthquakes in the case when the effects of dynamic triggering were observed. Accordingly, the seismic effect of explosions cannot trigger a large earthquake with deep source occurrence. Operations in open‐pit mines can only bring forward the moment of an earthquake at a potentially seismogenic fault. At the same time, the numerical calculations reveal that a branching network of underground tunnels located at several horizons can noticeably reduce the effective shear modulus of the host rock. This effect can even provoke a dynamic movement at a previously aseismic fault.
Co‐occurrence of nonsuicidal self‐injury and eating disorder pathology in adolescents
Authors: Reas Deborah Lynn , Wisting Line , Lindvall Dahlgren Camilla 
Published: December 2022

AbstractObjectiveLittle is known about the co‐occurrence of nonsuicidal self‐injurious (NSSI) behaviors and eating disorder (ED) pathology in community samples of adolescents.MethodsA total of 1558 Norwegian upper secondary school students (Grades 11, 12, and 13) completed the Deliberate Self‐Harm Inventory and a measure of ED pathology.ResultsAdolescents (53.1% F, 46.9% M) were a mean age of 17.1 years. A higher level of ED pathology was reported (12.1 vs. 5.3, p < .001) among adolescents who had a history of NSSI. Significantly higher levels of ED pathology were found among females who reported hitting themselves until bruised, head banging, severe scratching, and burning with a lighter, but not cutting, or the other forms of self‐injury. Of adolescents with a history of NSSI, 60% of females and 15% of males scored above a cutoff for ED pathology. Of adolescents scoring above a cutoff for ED pathology, 42.5% of females and 37.1% of males had engaged in lifetime NSSI.DiscussionAdolescents—in particular, females— with a history of NSSI reported significantly greater ED pathology. Notably, a higher proportion of males with ED pathology reported lifetime self‐injury than vice versa, underscoring the importance of carefully screening for the presence of self‐harm among males with ED pathology.Public Significance StatementOver 1500 upper secondary school students with an average age of 17 years completed an online survey assessing current ED pathology and lifetime NSSI. Adolescents, particularly females, with a history of self‐harm reported significantly more ED pathology. Findings also indicated the need to carefully screen for self‐harm among males with ED pathology. Parents, schools, and health professionals should be aware that self‐harm and ED pathology commonly co‐occur and warrant assessment.
Partner intrinsic characteristics influence foraging trip duration, but not coordination of care in wandering albatrossesDiomedea exulans
Authors: McCully Fionnuala R. , Weimerskirch Henri , Cornell Stephen J. , Hatchwell Ben J. , Cairo Milena , Patrick Samantha C. 
Published: December 2022

AbstractLong‐lived monogamous species gain long‐term fitness benefits by equalizing effort during biparental care. For example, many seabird species coordinate care by matching foraging trip durations within pairs. Age affects coordination in some seabird species; however, the impact of other intrinsic traits, including personality, on potential intraspecific variation in coordination strength is less well understood. The impacts of pair members' intrinsic traits on trip duration and coordination strength were investigated using data from saltwater immersion loggers deployed on 71 pairs of wandering albatrossesDiomedea exulans. These were modeled against pair members' age, boldness, and their partner's previous trip duration. At the population level, the birds exhibited some coordination of parental care that was of equal strength during incubation and chick‐brooding. However, there was low variation in coordination between pairs and coordination strength was unaffected by the birds' boldness or age in either breeding stage. Surprisingly, during incubation, foraging trip duration was mainly driven by partner traits, as birds which were paired to older and bolder partners took shorter trips. During chick‐brooding, shorter foraging trips were associated with greater boldness in focal birds and their partners, but age had no effect. These results suggest that an individual's assessment of their partner's capacity or willingness to provide care may be a major driver of trip duration, thereby highlighting the importance of accounting for pair behavior when studying parental care strategies.
Passive sampling hypothesis did not shape microbial species–area relationships in open microcosm systems
Authors: Deng Wei , Cheng Yi‐Ting , Li Zheng‐Qiang , Zhou Fa‐Ping , Yang Xiao‐Yan , Xiao Wen 
Published: December 2022

AbstractThe passive sampling hypothesis is one of the most important hypotheses used to explain the mechanism of species–area relationships (SAR) formation. This hypothesis has not yet been experimentally validated due to the confusion between passive sampling (a larger area may support more colonists when fully sampled) and sampling effects (more sampling effort will result in increased species richness when sampling is partial). In this study, we created an open microcosm system with homogeneous habitat, consistent total resources, and biodiversity background using Chinese paocai soup, a fermented vegetable, as a substrate. We made efforts to entirely exclude the influence of sampling effects and to exclusively obtain microorganisms from dispersal using microcosm and high‐throughput sequencing techniques. However, in this study, passive sampling based on dispersal failed to shape SAR, and community differences were predominantly caused by species replacement, with only minor contributions from richness differences. Ecological processes including extinction and competitive exclusion, as well as underlying factors like temporal scales and the small island effects, are very likely to have been involved in the studied system. To elucidate the mechanism of SAR development, future studies should design experiments to validate the involvement of dispersal independently.
NR4A3 fusions characterize a distinctive peritoneal mesothelial neoplasm of uncertain biological potential with pure adenomatoid/microcystic morphology
Authors: Agaimy Abbas , Brcic Luka , Briski Laurence M. , Hung Yin P. , Michal Michael , Michal Michal , Nielsen G. Petur , Stoehr Robert , Rosenberg Andrew E. 
Published: December 2022

AbstractA focal adenomatoid‐microcystic pattern is not uncommon in peritoneal mesothelioma, but tumors composed almost exclusively of this pattern are distinctly rare and have not been well characterized. A small subset of mesotheliomas (mostly in children and young adults) are characterized by gene fusions including EWSR1/FUS::ATF1, EWSR1::YY1, and NTRK and ALK rearrangements, and often have epithelioid morphology. Herein, we describe five peritoneal mesothelial neoplasms (identified via molecular screening of seven histologically similar tumors) that are pure adenomatoid/microcystic in morphology and unified by the presence of an NR4A3 fusion. Patients were three males and two females aged 31–70 years (median, 40 years). Three presented with multifocal/diffuse and two with a localized disease. The size of the individual lesions ranged from 1.5 to 8 cm (median, 4.7). The unifocal lesions originated in the small bowel mesentery and the mesosigmoid. Treatment included surgery, either alone (three) or combined with hyperthermic intraperitoneal chemotherapy (two), and neoadjuvant or adjuvant chemotherapy (one case each). At the last follow‐up (6–13 months), all five patients were alive and disease‐free. All tumors were morphologically similar, characterized by extensive sieve‐like microcystic growth with bland‐looking flattened cells lining variably sized microcystic spaces and lacked a conventional epithelioid or sarcomatoid component. Immunohistochemistry confirmed mesothelial differentiation, but most cases showed limited expression of D2‐40 and calretinin. Targeted RNA sequencing revealed an NR4A3 fusion (fusion partners were EWSR1 in three cases and CITED2 and NIPBL in one case each). The nosology and behavior of this morphomolecularly defined novel peritoneal mesothelial neoplasm of uncertain biological potential and its distinction from adenomatoid variants of conventional mesothelioma merit further delineation as more cases become recognized.
Impact of anti‐SARS‐CoV‐2 monoclonal antibodies in the management of patients with lymphoma and COVID19: A retrospective study
Authors: Assanto Giovanni Manfredi , Di Rocco Alice , Malfona Francesco , Capriata Marcello , Del Giudice Ilaria , Petrucci Luigi , Girardi Paola , D’Elia Gianna Maria , Martelli Maurizio , Gentile Giuseppe , Micozzi Alessandra , Pulsoni Alessandro 
Published: December 2022

AbstractCOVID19 in patients affected by lymphoma represents an important challenge because of the higher mortality rate. Anti‐SARS‐CoV‐2 monoclonal antibodies (anti‐S MoAbs) appear promising in this setting. We report a monocentric retrospective study including 176 patients affected by lymphoma which developed SARS‐CoV‐2 infection since the start of COVID19 pandemic. Overall, mortality was 13.1%, with a decreasing trend between first waves to the last wave of pandemic (18.5% vs. 9.4%, p 0.076). Patients receiving anti‐S MoAbs (41.3%) showed inferior mortality rate (overall survival, OS 93.2% vs. 82.7%, p 0.025) with no serious toxicity, reduced documented pneumonia (26% vs. 33%, p 0.005), and reduced need of oxygen support (14.5% vs. 35.7%, p 0.003). Among patients who received 3 doses of vaccine, the employment of anti‐COVID MoAbs showed a trend of superior survival versus those who did not receive Anti‐S MoAbs (OS rates 97.3% vs. 84.2%, p 0.064). On multivariate analysis, active haematological disease (OS 72% (HR 2.49 CI 1.00–6.41), bendamustine exposure (OS 60% HR 4.2 CI 1.69–10.45) and at least one comorbidity (HR 6.53 CI 1.88–22.60) were independent prognostic factors for death. Our study confirms the adverse prognostic role of COVID‐19 in lymphoma patients in presence of active disease, comorbidities and previous exposure to bendamustine. In our experience, anti‐S MoAbs represented a therapeutic option in vaccinated patients.
Inequalities in the omission of axillary dissection in sentinel lymph node positive patients in the Netherlands: Innovative hospitals are early adopters of a de‐escalating approach
Authors: van Steenhoven Julia E. C. , van Maaren Marissa C. , Verreck Eline E. F. , Schipper Robert J. , Nieuwenhuijzen Grard A. P. , Kuijer Anne , Siesling Sabine , van Dalen Thijs 
Published: December 2022

AbstractDuring the last decade completion axillary lymph node dissection (cALND) was gradually omitted in sentinel lymph node positive (SLN+) breast cancer patients. However, adoption varies among hospitals. We analyzed factors associated with the omission of cALND in all Dutch SLN+ patients. As one of the focus hospital‐related factors we defined “innovative” as the percentage of gene‐expression profile (GEP) deployment within the indicated group of patients per hospital as a proxy for early adoption of innovations. cT1‐2N0M0 SLN+ patients treated between 2011 and 2018 were selected from the Netherlands Cancer Registry. Hospitals were defined to be innovative based on their GEP use. Multivariable logistic regression (MLR) was performed to assess the relationship between innovative capacity, patient‐, treatment‐ and hospital‐related characteristics and cALND performance. 14 317 patients were included. Treatment in a hospital with high innovative capacity was associated with a lower probability of receiving cALND (OR 0.69, OR 0.46 and OR 0.35 in modestly, fairly and very innovative, respectively). Other factors associated with a lower probability of receiving a cALND were age 70 and 79 years and ≥79 years (ORs 0.59 [95% CI: 0.50‐0.68] and 0.21 [95% CI: 0.17‐0.26]) and treatment in an academic hospital (OR 0.41 [95% CI: 0.33‐0.51]). Factors associated with an increased probability of undergoing cALND were HR−/HER2− tumors (OR 1.46 [95% CI: 1.19‐1.80]), macrometastatic lymph node involvement (OR 6.37 [95% CI: 5.70‐7.13]) and mastectomy (OR 4.57 [95% CI: 4.09‐5.10]). Patients treated in a hospital that early adopted innovations were less likely to receive cALND. Our findings endorse the need for studies on barriers and facilitators of implementing innovations.
Depression, anxiety, and psychological distress in Vietnamese pharmacy and non‐pharmacy students during COVID‐19 pandemic
Authors: Tran Van De , Nguyen Trung Kien , Dewey Rebecca Susan , Le Minh Hoang , Pham Duy Toan 
Published: December 2022

AbstractBackgroundGlobally, the coronavirus disease‐19 (COVID‐19) pandemic has had a devastating psychological impact on people, especially the healthcare workers/students, in many different community settings. Limited research has been reported on the mental health issue of healthcare students in Vietnam.ObjectivesThis study investigated and quantified depression, anxiety, and psychological distress levels among healthcare students, with an emphasis on comparing those studying pharmacy to students in other healthcare‐related disciplines, in Vietnam during the COVID‐19 pandemic.MethodsA cross‐sectional study recruited 2246 respondents between September 7 and October 7, 2021, in which 230 were pharmacy students with a mean age of 20.0 ± 1.6 years and most of them had a low COVID‐19 fear level. The standardized Patient Health Questionnaire–4 (PHQ‐4) scale, consisting of two subscales of PHQ‐2 and Generalized Anxiety Disorder‐2 (GAD‐2), was utilized for the screening of depression and anxiety levels.ResultsPharmacy students scored significantly higher on the PHQ‐4 psychological distress measure than non‐pharmacy students (mean 2.23 vs. 1.90, p = 0.039). Compared to non‐pharmacy students, pharmacy students had higher rates of anxiety (10.4% vs. 6.5%, p = 0.028).ConclusionThe prevalence of anxiety was higher among pharmacy students in comparison to non‐pharmacy students. These findings present a need to recognize and conduct early intervention measures for mental health problems in healthcare students, especially pharmacy students, during recovery from the COVID‐19 pandemic.
Development of 14‐gene signature prognostic model based on metastasis for colorectal cancer
Authors: Li Tong , Yu Qian , Liu Te , Yang Wenjing , Chen Wei , Jin Anli , Wang Hao , Ding Lin , Zhang Chunyan , Pan Baishen , Wang Beili , Guo Wei 
Published: December 2022

AbstractBackgroundMetastasis is the main cause of death of colorectal tumors, in our study a prognosis model was built by analyzing the differentially expressed genes between metastatic and non‐metastatic colorectal cancer (CRC). We used this feature to predict CRC patient prognosis and explore the causes of colorectal tumor metastasis by characterizing the immune status alteration.MethodsCRC patient data were obtained from TCGA and GEO databases. We constructed a risk prognostic model by using Cox regression and the least absolute shrinkage and selection operator (LASSO) based on CRC metastasis‐related genes. We also obtained a nomogram to predict the prognosis of CRC patients. Finally, we explored the underlying mechanism of these metastasis‐related genes and CRC prognosis using immune infiltration analysis and experimental verification.ResultsAccording to our prognostic model, in TCGA, the area under the curve (AUC) values of the training and test sets were 0.72 and 0.76, respectively, and 0.68 for the GEO external data set. This suggested that the treatment and prognosis of patients could be effectively determined. At the same time, we found that the B and T cells in both tissues and peripheral blood of high MR‐risk score patients were mostly in immune static or inactivated states compared with those of low MR‐risk score patients.ConclusionsMR‐risk score has a direct correlation with CRC patient prognosis. It is useful for predicting the prognosis and patient immune status for these patients.
UHPLC–MS/MS method for simultaneous quantification of doripenem, meropenem, ciprofloxacin, levofloxacin, pazufloxacin, linezolid, and tedizolid in filtrate during continuous renal replacement therapy
Authors: Kai Makoto , Tanaka Ryota , Suzuki Yosuke , Goto Koji , Ohchi Yoshifumi , Yasuda Norihisa , Tatsuta Ryosuke , Kitano Takaaki , Itoh Hiroki 
Published: December 2022

AbstractBackgroundSince severe infections frequently cause acute kidney injury (AKI), continuous renal replacement therapy (CRRT) is often initiated for regulation of inflammatory mediators and renal support. Thus, it is necessary to decide the antibiotic dosage considering the CRRT clearance in addition to residual renal function. Some of the hemofilters used in CRRT are known to adsorb antibiotics, and clearance of antibiotics may differ depending on the adsorptive characteristics of hemofilters. Although assay systems for blood and CRRT filtrate concentrations are required, no method for measuring antibiotics concentrations in filtrate has been reported. We developed a UHPLC–MS/MS method for simultaneous quantification of antibiotics commonly used in ICU, comprising carbapenems [doripenem (DRPM) and meropenem (MEPM)], quinolones [ciprofloxacin (CPFX), levofloxacin (LVFX) and pazufloxacin (PZFX)] and anti‐MRSA agents [linezolid (LZD), and tedizolid (TZD)] in CRRT filtrate samples.MethodsFiltrate samples were pretreated by protein precipitation. The analytes were separated with an ACQUITY UHPLC CSH C18 column under a gradient mobile phase consisting of water and acetonitrile containing 0.1% formic acid and 2 mM ammonium formate.ResultsThe method showed good linearity over wide ranges. Within‐batch and batch‐to‐batch accuracy and precision for each drug fulfilled the criteria of the US Food and Drug Administration guidance. The recovery rate was more than 87.20%. Matrix effect ranged from 99.57% to 115.60%. Recovery rate and matrix effect did not differ remarkably between quality control samples at different concentrations.ConclusionThis is the first report of a simultaneous quantification method of multiple antibiotics in filtrate of CRRT circuit.
Dysregulated ceRNA network modulated by copy number variation‐driven lncRNAs in breast cancer: A comprehensive analysis
Authors: Zhu Xiaotao , Song Jialu , Wang Mingzheng , Wang Xiaohui , Lv Lin 
Published: December 2022

AbstractBreast cancer is a malignancy harmful to physical and mental health in women, with quite high mortality. Copy number variations (CNVs) are vital factors affecting the progression of breast cancer. Detecting CNVs in breast cancer to predict the prognosis of patients has become a promising approach to accurate treatment in recent years. The differential analysis was performed on CNVs of long noncoding RNAs (lncRNAs) as well as the expression of lncRNAs, microRNAs (miRNAs) and mRNAs in normal tissue and breast tumor tissue based on The Cancer Genome Atlas (TCGA) database. The CNV‐driven lncRNAs were identified by the Kruskal–Wallis test. Meanwhile, a competitive endogenous RNA (ceRNA) network regulated by CNV‐driven lncRNA was constructed. As the Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses revealed, the mRNAs in the dysregulated ceRNA network were mainly enriched in the biological functions and signaling pathways, including the Focal Adhesion‐PI3K‐Akt–mTOR‐signaling pathway, the neuronal system, metapathway biotransformation Phase I and II and blood circulation, etc. The relationship between the CNVs of five lncRNAs and their gene expression in the ceRNA network was analyzed via a chi‐square test, which confirmed that except for LINC00243, the expression of four lncRNAs was notably correlated with the CNVs. The survival analysis revealed that only the copy number gain of LINC00536 was evidently related to the poor prognosis of patients. The CIBERSORT algorithm showed that five lncRNAs were correlated with the abundance of immune cell infiltration and immune checkpoints. In a word, by analyzing CNV‐driven lncRNAs and the ceRNA network regulated by these lncRNAs, this study explored the mechanism of breast cancer and provided novel insights into new biomarkers.