bluuebunny/crossref_metadata_2025_split huggingface dataset:
Optimized Removal of Hydroquinone and Resorcinol by Activated Carbon Based on Shea Residue (Vitellaria paradoxa): Thermodynamics, Adsorption Mechanism, Nonlinear Kinetics, and Isotherms
Authors: Amola Liouna Adoum , Kamgaing Theophile , Tiegam Tagne Rufis Fregue , Atemkeng Cyrille Donlifack , Kuete Idris-Hermann Tiotsop , Anagho Solomon Gabche 
Published: January 2022

The present work demonstrates the adsorption of hydroquinone (HQ) and resorcinol (R) by activated carbon based on shea residue (Vitellaria paradoxa). The adsorbent was prepared chemically by impregnation with sulfuric acid and coded by the acronym CAK-S. The central composite design (CCD) was used to optimize the main factors that influence the adsorption of HQ or R by activated carbon such as the initial concentration, the pH of the solution, the contact time, and the mass of the carbon on the expected response, which is the adsorbed quantity of the target pollutants. The optimal conditions obtained from the statistical analysis are as follows: concentration of 158 mg/L, pH 3, time of 120 min, and mass of 50 mg for the adsorption of HQ and concentration of 180 mg/L, pH 3, time of 86 min, and mass of 118 mg for the adsorption of R. The maximum quantities of HQ and R adsorbed are 45.02 mg/g and 33.65 mg/g, respectively. The analysis of variance (ANOVA) showed a good relationship between the variables involved with the coefficients of determination R2 = 98.69% for the adsorption of hydroquinone and R2 = 90.55% for that of resorcinol, which means that the model is more suitable to express the adsorbed amount according to the four optimized parameters. The experimental data obtained under these optimal conditions were simulated with two and three parameter nonlinear isotherm models as well as kinetic models. The results show that Elovich kinetic model better describes the adsorption of HQ and R, indicating chemisorption with heterogeneous active sites on the surface of CAK-S. Temkin’s two-parameter model shows that adsorption occurs on heterogeneous surfaces with a nonuniform adsorption energy distribution at the surface and Sips’s three-parameter model confirms the heterogeneity of the surface with a localized adsorption of HQ or R by CAK-S. The thermodynamics study has shown that the adsorption is endothermic (

Δ

H

0

>
0

) and spontaneous (

Δ

G

0

<
0

).
X-Shaped Slotted Patch Biomedical Implantable Antenna for Wireless Communication Networks
Authors: Ahmad Sarosh , Manzoor Bilal , Naseer Salman , Santos-Valdivia Nilton , Ghaffar Adnan , Abbasi Muhammad Inam 
Published: January 2022

Biomedical implantable antennas have a major role in biomedical telemetry applications. Therefore, a compact-size low-profile implantable antenna working in industrial, scientific, and medical (ISM) band at 915 MHz is presented. The presented antenna is a simple slotted patch fed with a coaxial probe of 50 Ω impedance. The patch consists of four slotted resonators printed on a flexible Roger Duroid RT5880 substrate (

ε

r

=
2.2

,

tan
δ
=
0.0009

) with the standard thickness of 0.254 mm. The complete volume of the designed antenna is

7

mm
×
7

mm
×
0.254

mm

(

0.08

λ

g

×
0.08

λ

g

×
0.003

λ

g

). The antenna covers the bandwidth from 800 MHz to 1 GHz (200 MHz) inside skin tissue. A good agreement between the simulation and measurements of the antenna has been obtained. Finally, the specific absorption rate (SAR) values have also been analyzed through simulations as 8.17 W/kg inside skin over 1 g of mass tissue. The proposed SAR values are less than the limit of the Federal Communications Commission (FCC). This antenna is miniaturized and an ideal applicant for applications in biomedical implants.
Perceived Parental Knowledge Reduces Risk for Initiation of Nicotine and Cannabis Vaping: A Longitudinal Study of Adolescents
Authors: Mantey Dale S. , Clendennen Stephanie L. , Springer Andrew E. , Harrell Melissa B. 
Published: January 2022

Purpose This study examines the role of perceived parental knowledge on initiation of nicotine and cannabis vaping among youth. Design Longitudinal study from a self-administered online survey. Three waves of data collected in 6-month intervals. Setting 79 public and private schools in Texas. Participants Adolescents who self-reported never using e-cigarette to vape nicotine (n=1907; weighted sample [N] = 304371) or vape cannabis (n=2212; N=351955) at baseline. Participants were in 8th, 10th, and 12th grade at baseline. Measures Self-reported measures of nicotine and cannabis vaping. Analyses Weighted multivariate logistic regression models examined role of perceived parental knowledge at baseline (Spring 2016) as a predictor of nicotine and cannabis vaping initiation at 6-month (Fall 2016) and 12 month (Spring 2017) follow-up. Covariates were age, sex, race/ethnicity, and other tobacco use. Results Initiation rates were 5.9% for nicotine vaping and 8.6% for cannabis vaping, at 12-month follow-up overall. Higher perceived parental knowledge was associated with lower odds of nicotine vaping initiation at 6 months (adj OR: .69; 95% CI: .50-.93) and 12 months (adj OR: .68; 95% CI: .50-.92). Similarly, higher perceived parental knowledge was associated with lower odds of cannabis vaping initiation at 6 months (adj OR: .58; 95% CI: .38-.87) and 12 months (adj OR: .53; 95% CI: .38-.74). Conclusion E-cigarette prevention efforts directed at adolescents should incorporate parent engagement strategies as a method of increasing actual and perceived parental knowledge of their child’s location, activities and peer groups.
Sandplay therapy could be a method to decrease disease activity and psychological stress in children with systemic lupus erythematosus
Authors: Li Jinjiao , Shi Yanjun , Zhou Wei 
Published: January 2022

Objective Although the prevalence rate of childhood-onset systemic lupus erythematosus (cSLE) is far lower than that of adults, cSLE has a high rate of organ involvement, rapid development and poor prognosis, which is more serious than that in adults. And studies have shown that a wide range of physiological, functional, nerve, and organ damage will have a great impact on the mental health of children. At present, there is no relevant psychological intervention research for cSLE in China. This paper aimed to explore the effect of Sandplay therapy on mental health and disease activity of children with cSLE. Methods Forty childrens with cSLE were randomly divided into control group (CG) and intervention group (IG); the CG were treated with glucocorticoid, immunosuppressant and other drugs, while the IG were treated with Sandplay therapy in addition to drug therapy, at the time of 0, 2, and 4 weeks after initial diagnosis, respectively. The questionnaire evaluation and related clinical indicators of the two groups were compared and analyzed (before psychotherapy intervention) at 0, 2, 4, and 12 weeks after initial diagnosis. Results There was no significant difference between the two groups in the evaluation of questionnaire and related clinical indicators at the time 0, 2 weeks after initial diagnosis respectively. At 12 weeks after the intervention, the score of Short version of the Children’s Depression Inventory (CDI-S) in the IG was significantly lower than that in the CG, the score of The Screen for Child Anxiety Related Emotional Disorders (SCARED) scale in the IG was significantly lower than that in the CG, and the Pediatric Quality of Life Inventory (PedsQL 4.0) showed that the scores of social function, school performance, and emotional health of the IG were higher than those of the CG ( p < 0.05), and the clinical indexes of the IG were better than those of the CG ( p < 0.05). Conclusion Sandplay therapy may help to slow down the occurrence and development of anxiety and depression and reduce disease activity in patients with cSLE.
Impact of the insertion of the clinical pharmacist in the Allogeneic Hematopoietic Stem Cells Transplantation team
Authors: Zanetti Maria Olívia Barboza , Rodrigues João Paulo Vilela , Varallo Fabiana Rossi , Cunha Renato Luiz Guerrino , Simões Belinda Pinto , Pereira Leonardo Régis Leira 
Published: January 2022

Introduction Allogeneic Hematopoietic Stem Cells Transplantation (allo-HSCT) is capable of curing patients with neoplastic or non-neoplastic hematologic disorders or of prolonging their survival. This study assessed if the insertion of the clinical pharmacist in the allo-HSCT team modified the outcomes: transplantation-related mortality, grafting failure, incidence of Graft versus Host Disease, hospitalization time, time for grafting, number of readmissions, number of drug-related problems (DRPs), adherence and knowledge about pharmacotherapy. Methods Interventional study with historical control carried out in an allo-HSCT unit, in which the intervention group (IG) included 33 individuals who received pharmacotherapy follow-up. Control Group (CG) consisted of 28 individuals. Results A total of 250 DRPs were identified, 59 team's doubts were clarified, and 309 interventions were conducted in the IG. The DRPs mainly arose from safety (51.60%) and effectiveness (38.40%) problems. A mean of 9.36 (SD = 6.97) interventions per patient was obtained, mainly including dose reductions (19.09%), adjustments in administration time (18.12%), educational activities (15.21%) and drug removal (10.68%). Clinical significance of the interventions was considered high (75.7% extremely significant, very significant or significant), as well as their acceptability (89.7% accepted). Each patient attended a mean of 4.68 pharmaceutical consultations (SD = 1.91) after hospital discharge, presenting increase in knowledge (p = 0.0001) and in adherence (p = 0.0115). There was no evidence of differences between the groups in the other outcomes analyzed. Conclusions The pharmacotherapy follow-up allowed detecting several DRPs and performing interventions of high clinical relevance and acceptability, in addition to improving adherence and individualizing the pharmacotherapy.
Design timescapes: futuring through visual thinking
Authors: Cooper Clare M 
Published: January 2022

Encouraging designers to think about the precedents and consequences of their designs is integral to generating a design ethic that respects both our past and future generations (see Escobar, ‘Sustainability: Design for the pluriverse’, 2011, and Fry, Design Futuring, 2009). Situating designs as interventions in time also clearly acknowledges our growing responsibilities as designers in the age of the Anthropocene. The visualization of these relationships serves not only the designer engaged in the research, but those from other disciplines seeking to understand what historical or sociopolitical contexts may have informed a particular design innovation at a particular moment in time. In this reflective practitioner piece, the author presents design timescapes, a novel visual thinking tool that not only challenges designers to visualize the relationships between design and societal shifts but encourages the development of visual argumentation for design proposals. This approach is also useful in introducing the concept of design futuring to students/designers unfamiliar with this emergent field. To illustrate the various manifestations of this tool, she shares examples of where she has applied design timescapes as part of her futuring practice, and as a pedagogical tool. She concludes by offering suggestions for how this tool, in combination with emerging design futuring practice, contributes to the expansion of the resources of visual communication, design practice, research, and education.
Clinical research nurses, perspectives on recruitment challenges and lessons learnt from a large multi-site observational study
Authors: Imran Ambreen , Mpofu Sithembinkosi , Weldon Sharon Marie 
Published: January 2022

Background Recruitment of large numbers of study participants within a designated time frame for multi-site clinical research studies is a significant challenge faced by researchers. If a study does not manage to recruit targeted number of participants, it could have a significant impact on the statistical significance of the research. Purpose This paper highlights the challenges of recruitment for a large multi-site UK-based tuberculosis observational study ‘PREDICT’. Methods It uses a case-study analysis from the research nurses, perspective, and descriptive information retrieved from non-recruitment log forms to understand reasons for potential recruits not participating. Results Some of the main challenges to recruitment included patients not attending their clinic appointments, time required to obtain site-specific permissions and courier timings for blood sample collection. This paper also outlines key reasons for potential recruits who did not participate. Some of the common barriers to participation for non-recruited participants were work and family commitments, additional blood tests and language barriers. Conclusion Successful strategies which were implemented to overcome some of the challenges during the study are presented. This paper, therefore, aims to present the challenges faced, lessons learnt and successful strategies implemented to inform the planning of similar longitudinal studies of this scale in future.
Clinical and histological safety assessment of repeated intra-articular sevoflurane injections into knee joints of Sprague-Dawley rats
Authors: Achaerandio-de Nova Ainara , Berenguer-Romero María D , Nam Cham Syonghyun , Gómez-Juárez Sango Mónica , Losa-Palacios Sergio , Escudero-Jiménez Angel , Gerónimo-Pardo Manuel 
Published: January 2022

Objectives We investigated the effects of repeated intra-articular injections of liquid sevoflurane to articular structures, as this inhalational anesthetic is being repurposed as an antimicrobial agent, which would make sevoflurane a novel alternative for the treatment of septic arthritis. Methods The left knees of nine Sprague-Dawley rats were injected with 150 μL of liquid sevoflurane for five consecutive days, whereas the right knees were injected with the same volume of saline to serve as controls. Animals were examined daily for clinical signs of local and systemic toxic effects attributable to sevoflurane. Rats were euthanized in groups of three at days 7, 14, and 35 after the first injection, and left and right knees were sent for histological assessment. Results Local signs on knees consisted of transient bilateral scabs, and an unexpected subcutaneous emphysema affecting only left knees, which was attributed to sevoflurane. No rat presented with limp, and animal welfare was good during the study period. Two out of the three left knees from rats sacrificed at day 7 showed mild histological changes, specifically a mild infiltration of lymphocytes. All other seven left knees as well as all nine right knees were completely normal at histological examination. Conclusion We concluded that repeated intra-articular injections of sevoflurane seemed safe for articular structures in noninfected knees. Further studies focused on the safety of intra-articular sevoflurane in infected knees, as well as on its effectiveness for the treatment of septic arthritis are warranted.
Temporal characteristics of astrocytic activation in the TNC in a mice model of pain induced by recurrent dural infusion of inflammatory soup
Authors: Zhang Leyi , Lu Chenglong , Kang Li , Li Yingji , Tang Wenjing , Zhao Dengfa , Yu Shengyuan , Liu Ruozhuo 
Published: January 2022

Abstract
Background
Astrocytic activation might play a significant role in the central sensitization of chronic migraine (CM). However, the temporal characteristics of the astrocytic activation in the trigeminal nucleus caudalis (TNC) and the molecular mechanism under the process remain not fully understood. Therefore, this study aims to investigate the duration and levels change of astrocytic activation and to explore the correlation between astrocytic activation and the levels change of cytokines release.

Methods
We used a mice model induced by recurrent dural infusion of inflammatory soup (IS). The variation with time of IS-induced mechanical thresholds in the periorbital and hind paw plantar regions were evaluated using the von Frey filaments test. We detected the expression profile of glial fibrillary acidic protein (GFAP) in the TNC through immunofluorescence staining and western blot assay. We also investigated the variation with time of the transcriptional levels of GFAP and ionized calcium binding adapter molecule 1 (Iba1) through RNAscope in situ hybridization analysis. Then, we detected the variation with time of cytokines levels in the TNC tissue extraction and serum, including c-c motif chemokine ligand 2 (CCL2), c-c motif chemokine ligand 5 (CCL5), c-c motif chemokine ligand 7 (CCL7), c-c motif chemokine ligand 12 (CCL12), c-x-c motif chemokine ligand 1 (CXCL1), c-x-c motif chemokine ligand 13 (CXCL13), interferon gamma (IFN-γ), tumor necrosis factor alpha (TNF-α), macrophage colony-stimulating factor (M-CSF), interleukin 1beta (IL-1β), interleukin 6 (IL-6), interleukin 10 (IL-10), interleukin 17A (IL-17A).

Results
Recurrent IS infusion resulted in cutaneous allodynia in both the periorbital region and hind paw plantar, ranging from 5 d (after the second IS infusion) to 47 d (28 d after the last infusion) and 5 d to 26 d (7 d after the last infusion), respectively. The protein levels of GFAP and messenger ribonucleic acid (mRNA) levels of GFAP and Iba1 significantly increased and sustained from 20 d to 47 d (1 d to 28 d after the last infusion), which was associated with the temporal characteristics of astrocytic activation in the TNC. The CCL7 levels in the TNC decreased from 20 d to 47 d. But the CCL7 levels in serum only decreased on 20 d (1 d after the last infusion). The CCL12 levels in the TNC decreased on 22 d (3 d after the last infusion) and 33 d (14 d after the last infusion). In serum, the CCL12 levels only decreased on 22 d. The IL-10 levels in the TNC increased on 20 d.

Conclusions
Our results indicate that the astrocytic activation generated and sustained in the IS-induced mice model from 1 d to 28 d after the last infusion and may contribute to the pathology through modulating CCL7, CCL12, and IL-10 release.
The interaction of canonical Wnt/β-catenin signaling with protein lysine acetylation
Authors: You Hongjuan , Li Qi , Kong Delong , Liu Xiangye , Kong Fanyun , Zheng Kuiyang , Tang Renxian 
Published: January 2022

AbstractCanonical Wnt/β-catenin signaling is a complex cell-communication mechanism that has a central role in the progression of various cancers. The cellular factors that participate in the regulation of this signaling are still not fully elucidated. Lysine acetylation is a significant protein modification which facilitates reversible regulation of the target protein function dependent on the activity of lysine acetyltransferases (KATs) and the catalytic function of lysine deacetylases (KDACs). Protein lysine acetylation has been classified into histone acetylation and non-histone protein acetylation. Histone acetylation is a kind of epigenetic modification, and it can modulate the transcription of important biological molecules in Wnt/β-catenin signaling. Additionally, as a type of post-translational modification, non-histone acetylation directly alters the function of the core molecules in Wnt/β-catenin signaling. Conversely, this signaling can regulate the expression and function of target molecules based on histone or non-histone protein acetylation. To date, various inhibitors targeting KATs and KDACs have been discovered, and some of these inhibitors exert their anti-tumor activity via blocking Wnt/β-catenin signaling. Here, we discuss the available evidence in understanding the complicated interaction of protein lysine acetylation with Wnt/β-catenin signaling, and lysine acetylation as a new target for cancer therapy via controlling this signaling.
The Singularity Paramagnetic Peak of Bi0.3Sb1.7Te3 with p-type Surface State
Authors: Huang Shiu-Ming , Wang Pin-Cing , Chen Pin-Cyuan , Hong Jai-Long , Cheng Cheng-Maw , Jian Hao-Lun , Yan You-Jhih , Yu Shih-Hsun , Chou Mitch M. C. 
Published: January 2022

AbstractThe magnetization measurement was performed in the Bi0.3Sb1.7Te3 single crystal. The magnetic susceptibility revealed a paramagnetic peak independent of the experimental temperature variation. It is speculated to be originated from the free-aligned spin texture at the Dirac point. The ARPES reveals that the Fermi level lies below the Dirac point. The Fermi wavevector extracted from the de Haas–van Alphen oscillation is consistent with the energy dispersion in the ARPES. Our experimental results support that the observed paramagnetic peak in the susceptibility curve does not originate from the free-aligned spin texture at the Dirac point.
Significance of inflammatory biomarkers and urethral histology in patients with urethral stricture disease in relation to treatment outcome—a single centre prospective study in the north-eastern part of India
Authors: Bagchi Puskal Kumar , Saurabh Nikhil , Phukan Mandeep , Barua Sasanka Kumar , Sarma Debanga , Puthenveetil Rajeev Thekumpadam 
Published: January 2022

Abstract
Background
Inflammation plays a very important role in defining the urethral stricture. Inflammatory biomarkers may play an important role in predicting the underlying pathophysiology as well as outcome of surgery. Histology of urethral strictures along with histology of urethra proximal and distal to stricture segment may have a role in predicting the outcome of the surgery. The literature discussing this aspect is rare; thus, this novel study aimed to find out the role of inflammatory biomarkers and urethral histology in predicting the outcome of surgery in urethral stricture disease.

Methods
This prospective study had 105 patients with age more than 15 years with urethral stricture. Baseline characteristics, routine blood tests including inflammatory blood markers (CRP, ESR, HbA1C, fasting insulin, serum ferritin, etc.) were recorded. They underwent various types of surgery, and first biopsy was taken from stricture segment and second biopsy from proximal to stricture segment and third biopsy from distal to stricture segment and evaluated for the presence of features of lichen sclerosus and inflammation. Primary endpoint was to diagnose the role of inflammatory biomarkers and histology of stricture in stricture recurrence.

Results
Their mean age was 43.3 ± 13.46 years. Mean CRP of 11.54 ± 3.64 in patients with failure and 9.59 ± 2.77 in patients with successful outcome (p 0.025). Other inflammatory biomarkers like HbA1C, fasting insulin, ESR, serum ferritin, NLR had no significant correlation with the outcome. The presence of features of lichen sclerosus like hyperkeratosis and severe inflammation in stricture segment predicted higher likelihood of failure. Histology of proximal and distal segment of urethral stricture had no significant relationship in predicting outcome. Staged urethroplasty with buccal mucosal graft outperformed single-stage urethroplasty in biopsy-proven LS strictures.

Conclusions
The present study found a negative impact of increased CRP and the presence of features of lichen sclerosus in urethral histology with the outcome of urethral stricture disease. Thus, our study confirms that inflammatory biomarkers (CRP) and histology of stricture segment play a significant role predicting the outcome of surgery.