bluuebunny/crossref_metadata_2025_split huggingface dataset:
Systematic Review of Randomized Controlled Trials Evaluating the Use of Platelet-Rich Plasma for Knee Osteoarthritis: Adherence to Minimum Information for Studies Evaluating Biologics in Orthopaedics
Authors: Nakagawa Hirotaka F. , Kim James , Rinaldi Joseph , Rabinowitz Judy , Mautner Ken , DeMers Ariana , Sherman Seth , Borg-Stein Joanne , Sussman Walter I. 
Published: January 2025

Background: The Minimum Information for Studies Evaluating Biologics in Orthopedics (MIBO) guidelines were developed in May 2017 to encourage improved reporting standards, promote increased transparency and reproducibility, and enhance clinical evaluation capabilities. The MIBO guidelines consist of 23 checklist items considered necessary to critically appraise clinical studies evaluating platelet-rich plasma (PRP). Purpose: To assess randomized controlled trials that evaluated PRP for the treatment of knee osteoarthritis in order to systematically review their adherence to the MIBO guidelines. Study Design: Systematic review. Level 1a. Methods: A search was performed following the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. The inclusion criteria were randomized controlled trials reporting on knee osteoarthritis treated with intra-articular PRP. The studies were categorized into pre-, peri-, and post-MIBO groups based on the start date of data collection. The overall MIBO scores, defined as percentage of checklist items out of the 23 checklist items reported in 1 study, individual item scores, defined as percentage of studies reporting the checklist item within a specified group, and overall item score defined as the average of the individual item scores from all the included studies were calculated. Results: The review included 87 studies (7925 patients; 8118 knees). Of these, 51 studies were assigned to the pre-MIBO group, 19 studies to the peri-MIBO group, and 17 studies to the post-MIBO group. The overall MIBO score was 72%. No statistically significant differences in MIBO scores were found among the 3 MIBO groups ( P = .345). The majority of the studies (62 studies; 71%) had MIBO scores <80%. MIBO items with particularly low item scores included reporting of whole-blood characteristics (20%), platelet recovery rate (22%), PRP analysis (30%), and PRP activation (47%). No significant difference among the 3 MIBO groups was found for the item scores except for the reporting of the recipient details ( P = .012). Conclusion: This study highlights the deficiencies in adherence to the MIBO guidelines, particularly in reporting key variables such as whole-blood characteristics, platelet recovery rate, PRP analysis, and PRP activation. These findings suggest that the publication of the MIBO guidelines has not resulted in improved reporting practices in studies investigating intra-articular PRP for the treatment of knee osteoarthritis.
Lower ACLR Failure Rates in Bone–Soft Tissue Versus Soft Tissue–Only Allografts in Adults: A Systematic Review and Meta-analysis
Authors: Tabbaa Ameer , Atkins Myles , Montalvo Alicia M. , Petit Camryn B. , White Mia S. , Petushek Erich J. , Diekfuss Jed A. , Myer Gregory D. , Lamplot Joseph D. 
Published: January 2025

Background: While allografts are commonly used for anterior cruciate ligament reconstruction (ACLR), evidence to guide specific allograft selection is lacking. Purpose: To compare clinical and graft failure rates after ACLR using soft tissue–only allografts and bone–soft tissue allografts in adults. Study Design: Systematic review and meta-analysis; Level of evidence, 4. Methods: English-language studies with clinical outcome data on primary and revision ACLR in adults with nonirradiated soft tissue–only and bone–soft tissue grafts were identified in the search. Data extracted included allograft type, patient characteristics, follow-up time, and failure rates. The cumulative failure rate was defined as International Knee Documentation Committee grade C/D, graft retear, grade ≥2+ Lachman, grade ≥2+ pivot shift, and/or side-to-side KT-1000 laxity of >5 mm. The graft rupture rate was defined solely by the proportion of patients who had a graft rupture. Meta-analyses using the inverse variance method were used to estimate the pooled rates with 95% CIs. Subgroup analysis was conducted to compare allograft types and determine whether age, sex, and follow-up time influenced the estimates. Results: A total of 14 studies met the inclusion criteria: 7 investigated bone–soft tissue allografts, 6 investigated soft tissue–only allografts, and 1 investigated both. The comparative study showed a difference in the cumulative failure rate between bone–patellar tendon–bone and soft tissue–only allografts. The pooled cumulative failure rates for bone–soft tissue and soft tissue–only allografts were 11% (95% CI, 7-17) and 20% (95% CI, 14-29), respectively ( P = .05). The pooled graft rupture rates for bone–soft tissue and soft tissue–only allografts were 6% (95% CI, 4-9) and 13% (95% CI, 7-23), respectively ( P = .07). Conclusion: The meta-analysis results showed that bone–soft tissue allografts have lower cumulative failure rates than soft tissue–only allografts. Bone–soft tissue allografts may be the preferred allograft choices for ACLR.
Comparison of the use of standard heparin and 0.9% saline as lock solution in hemodialysis catheter: Importance of closure technique
Authors: Ergül Fatih , Dağ Mikail , Doğan Beyza , Erkuş Edip , Guney Ibrahim , Karaköse Süleyman 
Published: January 2025

Background: Bleeding and thrombotic occlusion are complications of Central venous catheters. When selecting a catheter lock solution, factors such as bleeding, thrombotic occlusion, infection, and cost-effectiveness must be considered. Methods: The study included 35 patients who used heparin as a locking solution and 35 patients who used 0.9% saline, retrospectively. In our center, after injecting the solution equal to the catheter lumen volume from the syringe, approximately 1 cc of locking solution is left in the syringe, the catheter is locked and the syringe is removed from the catheter after locking. Intergroup complications were observed. Results: No significant difference was observed between the groups concerning the catheter insertion site ( p = 0.143 and 0.143). Additionally, no significant differences were found between the groups in terms of thrombosis and bleeding complications ( p = 0.314 and 0.239, respectively). Conclusion: Our study concluded that heparin locking is not superior to normal saline locking in terms of catheter dysfunction. We aimed to emphasize that the technique of catheter locking is more important than the type of lock solution used.
Neutrophils to lymphocytes ratio as a predictor of BCG response in non-muscle invasive bladder cancer
Authors: Higazy Ahmed , Elsawy Amr , Lofty Ahmed , Abdallah Hany M , Radwan Ahmed 
Published: January 2025

Aim: To evaluate the role of preoperative neutrophils to lymphocytes ratio (NLR) as a predictor for the response to BCG in patients with non-muscle invasive bladder cancer (NMIBC). Materials: Nighty six patients with NMIBC were prospectively included in our study. Our study population was classified into two groups, based on pre-operative (NLR) either ⩽ or > 3. After receiving BCG, patients were followed up for 3 years to evaluate the correlation between BCG failure and (NLR). Results: Nighty two patients were evaluated at the end of our study. The NLR > 3 group of patients showed a higher age and T stage compared to the NLR ⩽ 3 group with a significant difference. BCG failure was reported to be higher in the NLR > 3 group with a failure rate of 66.7% compared to 28.3% in the other group ( p-value < 0.001). Time to failure in NLR > 3 group compared to NLR ⩽ 3 group was 10.44 ± 4.3 and 15 ± 3.9 months respectively with a ( p-value = 0.002). Univariate and multivariate logistic regression revealed that the most significant predictors of BCG failure were NLR > 3, Initial T stage, and age respectively. Conclusion: BCG response is highly affected by the NLR, with a higher failure rate with NLR > 3.
Associations Between Sleep Duration and Lifestyle Risk Factors Among Adolescents: A Cross-Sectional Study
Authors: Li Yueqi , Chang Jen Jen , Burroughs Thomas E. 
Published: January 2025

Purpose Examining the associations between sleep duration and lifestyle risk factors and assessed whether sex modify such associations among U.S. adolescents. Design Cross-sectional study among high school students from the 2015-19 national Youth Risk Behavior Survey. Setting US, national. Subjects High school students grade 9-12 (n = 31 871). Measures Students reported hours of sleep on an average school night categorized into “less than 6 hours”, “6 to 7 hours” and “8 hours and more”. Lifestyle risk factors including physical inactivity, insufficient breakfast consumption, current tobacco use, and current binge drinking were self-reported and dichotomized. Analysis Multivariable logistic regression models were used to estimate associations between sleep duration and lifestyle risk factors, adjusting for confounders. Results Compared to students with 8 hours and more of sleep, students with 6 to 7 hours and less than 6 hours of sleep had 79% and 228% ( P < .01) increased odds of insufficient breakfast consumption; and had 22% ( P = 0.0014) and 74% ( P < .01) increased odds of binge drinking, respectively. There is a significant interaction between sleep duration and sex ( P < .05) for physical inactivity and current tobacco use. Conclusion Insufficient sleep is common among US adolescents and is associated with increased risks of multiple lifestyle risk factors, which suggests great needs for multilevel interventions to address sleep deprivation and promote good sleep hygiene among adolescents.
Electroacupuncture improves postoperative cognitive dysfunction by inhibiting ferroptosis via the TFR1-DMT1-FPN pathway
Authors: Chen Tianren , Zhang Binsen , Zhang Xiaojia , Tang Lu , Wang Chunai 
Published: January 2025

Objective: The aim of this study was to investigate the role of ferroptosis in the occurrence of postoperative cognitive dysfunction (POCD) using a mouse model and to elucidate whether electroacupuncture (EA) can improve POCD by suppressing ferroptosis via the transferrin receptor 1 (TFR1)—divalent metal transporter 1 (DMT1)—ferroportin (FPN) pathway. Methods: The experiment involved three groups: the control group, the POCD group and the POCD + EA group. The POCD animal model was established using sevoflurane anesthesia and tibial fracture. Cognitive and behavioral changes in mice were assessed using the novel object recognition test (NORT) and the Morris water maze (MWM) test, 1 and 3 days after surgery. Transmission electron microscopy was performed to observe changes in the mitochondrial structure of hippocampal tissue. Enzyme-linked immunosorbent assay was conducted to determine the levels of glutathione (GSH) and iron ion (Fe) concentrations. Western blot analysis was used to measure the expression of TFR1, DMT1 and iron pump protein. Quantitative reverse transcription-polymerase chain reaction (qRT-PCR) was employed to detect the mRNA levels of DMT1 and FPN. Results: Based on the experimental results of the MWM test and the NORT, we found that EA can improve POCD in mice. Observation by projection electron microscopy showed that EA improved the mitochondrial structure in the hippocampus. The enzyme-linked immunosorbent assay (ELISA) results showed that EA suppressed ferroptosis in the hippocampal area. The qRT-PCR and Western blot results suggested that EA suppresses ferroptosis by regulating the TFR1-DMT1-FPN pathway. Conclusion: This study reveals that sevoflurane and tibial fractures cause cognitive damage through the mechanism of ferroptosis, while EA may inhibit ferroptosis through the TFR1-DMT1-FPN pathway and improve POCD when induced in this way.
A Qualitative Inquiry of Patients Using Virtual Reality to Mitigate Cancer Pain
Authors: Groninger Hunter , Ali Nadia , Gomes Kylie , Violanti Diana 
Published: January 2025

Introduction Virtual reality (VR) is a rapidly evolving technology that has been shown to improve pain severity in different disease states, including cancer. To date, VR pain studies have used off-the-shelf products for pain distraction. What are user preferences for VR content to mitigate cancer pain?. Objective Through qualitative inquiry, we aim to explore and understand user preferences for VR distraction therapies to mitigate cancer-related pain. Methods We conducted semi-structured interviews of 12 patients participating in a VR cancer pain therapy clinical trial. Using a grounded theory approach, emerging themes and subthemes were analyzed to elucidate patient experiences and preferences for VR content. Results Participants described distinct themes related to VR use, specifically experiences of immersion, distraction, relaxation, and safety. Higher experience of immersion and distraction were associated with improvement in cancer pain severity. Some participants had to adapt to VR technology to use it successfully. Regarding future VR content development, participants voiced preferences for content related to home, childhood, natural environments, and family and friends. Conclusion Patients associate higher levels of virtual immersion and familiar, natural virtual experiences with successful VR distraction therapy for cancer pain analgesia.
Skill transfer of upper limb prosthesis control after training in a virtual reality environment
Authors: Maas Bart , Tchimino Jack , van Dijk Bram , Murgia Alessio , van der Sluis Corry K , Bongers Raoul M 
Published: January 2025

Background Controlling a myoelectric arm prosthesis after amputation is a skill that is difficult to master and requires extensive training since muscles need to be activated in a specific manner. One novel type of training places the prosthesis user in a virtual reality environment (VRE) to train; however, it is not yet clear if skill transfer occurs from the training to actual prosthesis use. Objective The aim of the current study is to examine skill transfer of VRE training. Methods A total of 20 able-bodied participants were divided into two training groups. One group trained with a newly developed VRE system and the other trained using a prosthesis simulator. Both groups performed five training sessions in a pre-test/post-test design where functional control, motivation and perceived workload were measured. Results The results showed that both groups improved from pre-test to post-test on functional control and motivation but not on the workload. Interestingly, almost no differences in improvements between groups were found indicating that there was no difference in effectiveness between training methods. Conclusion Based on these results, we can conclude that we found skill transfer of VRE training. Therefore, VRE training is an effective training method for arm prosthesis control and has valuable potential for implementation in a rehabilitation setting.
Clinicopathological Features and Prognoses of Patients With Splenic Metastases From Breast Cancer: A Single-Centre, Retrospective Study
Authors: Xie Xiaofeng , Ma Mingrui , Bai Xue , Hu Jing , Zheng Haijie , Guo Xiongqi , Huang Jiayi , Chen Xuelian , Chen Liping , Lan Xiaofeng , Song Lin , Du Caiwen 
Published: January 2025

Purpose Splenic metastases (SM) from breast cancer (SMBC) are exceedingly rare. To date, the relevant literature is primarily based on pan-tumour species, with only a few studies exploring SM specifically in relation to breast cancer. As such, the present retrospective study explored the clinicopathological characteristics and prognoses of patients with SMBC at the breast care centre of the authors’ hospital. Methods Data from patients newly diagnosed with metastatic breast cancer (MBC) between June 2017 and June 2022 were extracted from medical records at the authors’ hospital. Clinicopathological characteristics and their associations with progression-free survival (PFS [time from diagnosis of initial recurrence and/or metastasis to diagnosis of SM]), first overall survival (1stOS [time from diagnosis of breast cancer to death or last follow-up visit]), and second overall survival (2ndOS [time from diagnosis of SM to death or last follow-up visit]) were analysed in patients with SMBC. Results In total, 1009 patients with MBC were identified, of whom 18 (1.7%) had SM. T1 and T2 stages were documented in 15 (83.3%) patients, whereas N2 and N3 were documented in 13 (62.2%). 14 (77.8%) patients were oestrogen receptor and/or progesterone receptor positive. A Ki-67 index ≥ 30% accounted for 72.2% (13/18) of cases, and all patients were histological grade II or III. Liver and/or lung metastases were documented in all 18 (100%) patients. Median PFS was 6.3 months. The median 1stOS and 2ndOS were 41.8 and 10.6 months, respectively. The number of previous treatment lines before diagnosis of SM was a significant adverse prognostic factor for PFS, and disease-free survival was a significant adverse prognostic factor for 1stOS. Conclusion SMBC commonly presents with diffuse multiple organ metastases in the terminal stage of malignancy and has a poor prognosis, which may provide deeper insight into SMBC for clinicians.
The Nonclinical Safety Assessment of a Novel Anti-CEACAM5 Antibody Exatecan Conjugate Predicts a Low Risk for Interstitial Lung Disease (ILD) in Patients—The Putative Mechanism Behind ILD
Authors: Sloot Willem N. , Bertotti Elisa , Onidi Manuela , Paoletti Andrea , Salve Ilse De , Tavano Patrizia , Vigna Enrico , Mueller Gundi 
Published: January 2025

The therapeutic window of antibody drug-conjugates (ADC) remains challenging due to safety issues such as interstitial lung disease (ILD) observed with specific deruxtecan-based ADCs. To avoid ILD, we designed M9140 by conjugating the maleimide-containing hydrophilic β-glucuronide linker to exatecan and our anti-CEACAM5 (CarcinoEmbryonic Antigen-related Cell Adhesion Molecule 5) specific antibody. Following repeated iv-infusion at 3 to 30 mg/kg of M9140 every 3 weeks, the pathological findings obtained in cynomolgus monkeys were confined to gastrointestinal and hematolymphoid tissues and resembled the toxicity of exatecan. At 24 mg/kg or higher, transient reductions in neutrophil and reticulocyte counts were observed with each dosing event along with reversible anemia throughout the study. The no observed adverse effect level was 24 mg/kg and the maximum tolerated dose was 30 mg/kg. The difference in toxicity by this small dose increment was correlated with a 2.5-fold difference in plasma exatecan exposure indicating antigen-independent toxicity. As anticipated, no lung toxicity was found with M9140 in these studies that were similar in study design to those used to confirm ILD with trastuzumab-deruxtecan in monkeys. Since the non-human primate model is regarded as predictive for the ILD risk in humans, this result indicates a low risk for ILD when applying M9140 to patients. The current M9140 safety data are discussed with special focus on the absence or presence of ILD with other antibody camptothecin-conjugates, for which a hypothetical pathogenic mechanism is postulated here. The favorable nonclinical profile of M9140 warrants further investigation in patients with CEACAM5-overexpressing tumors.
Recycling potential of 3D printed support waste as eco-friendly polymeric composites
Authors: Mathiazhagan N , Palaniyappan Sabarinathan , Tamilselvan M , Sivakumar Narain Kumar 
Published: January 2025

Nowadays 3D printing has excellent potential and attention over the traditional manufacturing technology and has more recycling possibilities. The present study focuses on the conversion of 3D printing raft support waste from the Fused Filament Fabrication (FFF) process and this waste can be converted into usable ecofriendly composites using ultrasonic joining technique. The joining study was done on the 3D printed supports of Poly Lactic Acid (PLA), Carbon fibre reinforced Poly Lactic Acid (CPLA), and Ceramic reinforced Poly Lactic Acid (CEPLA) samples. The samples are welded with 6 different combinations such as similar welding of PLA, CPLA and CEPLA, and dissimilar welding of CEPLA/CPLA, CEPLA/PLA, and CPLA/PLA. Similar and dissimilar ultrasonic welding was done with respect to varying the printing process parameters such as layer height, raster orientation and printing speed. The impact of various printing parameters on the joint possessions of the 3D printed supports was analysed in terms of the mechanical properties such as tensile strength and shore hardness value. The results show that, the maximum tensile strength was observed on the similar joints of Carbon fibre reinforced Poly Lactic Acid (CPLA) samples with layer height of 0.1 mm, printing speed of 20 mm/s and raster orientation of 90°. Fractured samples clearly shows that all the samples are failed under brittle mode of fracture and at lower printing speed the samples are evenly deposited, which results in proper bonding or fusion of the Joined raft support samples. This kind of refabrication method provides more benefit with lesser energy utilization compared to filament extrusion method for recycling of the 3D printed waste.
Protocol for optimizing robot-assisted autism therapy sessions through gaze analysis: A pilot study investigating optimal trial count for children with comorbid autism spectrum disorder and intellectual disability
Authors: Zahid Zunera , Ali Sara , Ayaz Yasar , Hassan Syed Mustafa , Nawaz Raheel 
Published: January 2025

Background Autism spectrum disorder poses challenges in social communication and behavior, while Intellectual disabilities are characterized by deficits in cognitive, social, and adaptive skills, frequently accompanied by stereotypies and challenging behaviors. Despite the progress made in autism spectrum disorder research, there is often a lack of research focusing on individuals with co-occurring autism spectrum disorder and intellectual disability. Robot-assisted autism therapies are effective in addressing these needs. However, there is a lack of consensus on the optimal number of therapy sessions required for effective outcomes, particularly in children with comorbid autism and intellectual disability. Objectives This study aims to investigate the optimal number of therapy sessions required for effective outcomes in robot-assisted autism therapy, specifically focusing on children with comorbid autism and intellectual disability. Gaze analysis metrics, including the average number of eye contact and average inter-eye contact delay, are utilized to assess therapy effectiveness. Methods This study integrates gaze analysis focusing on the average number of eye contact and average inter-eye contact delay as performance metrics. A pilot investigation was conducted to explore the critical temporal window for optimal trial count in robot-assisted autism therapy for children with autism. A mathematical model was introduced and validated for eight children with autism spectrum disorder, encompassing 56 experiments conducted over 7 weeks (one trial per week). Robots presented 8 cues in 3 categories (visual, speech, motion) with 16 cues per trial. Results and Conclusions The results, validated using single-sample Wilcoxon signed-rank tests, revealed that the unsaturated state, with a median score of 3.44, exhibited significantly lower average inter-eye contact delay (p-value = 0.014, r = 0.86) and significantly higher average number of eye contact (p-value = 0.014, r = 0.87) compared to the hypothesized medians. These findings suggest that the unsaturated state occurring in the critical temporal window has significantly higher average number of eye contact and lower average inter-eye contact delay compared to the saturated state. This study underscores the importance of tailored and targeted interventions for children with autism spectrum disorder, facilitating the development of cost-effective, time-efficient, evidence-based treatments.