bluuebunny/crossref_metadata_2025_split huggingface dataset:
Multi-View Acoustic Field Imaging With Digital Color Holography
Authors: Hassad Saoucene , Ferria Kouider , Bouamama Larbi , Picart Pascal 
Published: June 2022

This paper proposes an approach for acoustic field imaging using simultaneous multi-view digital holography based on three-color digital off-axis holography. Considering spatio-chromatic multiplexing and the recording with a monochrome sensor, the numerical processing of time-sequences of holograms yields both the amplitude and phase of the acoustic field along three different directions of observation. Distortion analysis is presented and the acousto-optic interaction along the optical beam is discussed using a theoretical modelling. Experimental results with an emitter at 40 kHz establish the proof-of-concept of the proposed multi-view imaging for acoustic fields.
CasEcR and CasMIH Genes in the Blue Crab, Callinectes sapidus: A Temporal Evaluation and Melatonin Effects
Authors: David Daniela Dantas , de Assis Leonardo Vinícius Monteiro , Moraes Maria Nathalia , Zanotto Flávia Pinheiro , Castrucci Ana Maria de Lauro 
Published: June 2022

Environmental cues synchronize endogenous rhythms of many physiological processes such as hormone synthesis and secretion. Little is known about the diurnal pattern of hormones and gene expression of the Callinectes sapidus molt cycle. We aimed to investigate in the eyestalk and hepatopancreas of premolt and intermolt C. sapidus the following parameters: 1) the diurnal expression of the ecdysteroid receptor CasEcR isoforms, and the molt inhibiting hormone CasMIH; 2) the diurnal hemolymph ecdysteroid and melatonin levels; and 3) melatonin effects on the transcripts of the above-mentioned genes in intermolt C. sapidus. Ecdysteroid levels were higher in the premolt than the intermolt animals at all time points evaluated (ZTs). Premolt crabs displayed a variation of ecdysteroid concentration between time points, with a reduction at ZT17. No difference in the melatonin level was seen in either molt stage or between stages. In the eyestalk of intermolt animals, CasEcR expression oscillated, with a peak at ZT9, and premolt crabs have a reduction at ZT9; CasMIH transcripts did not vary along 24 h in either molt stage. Moreover, the evaluated eyestalk genes were more expressed at ZT9 in the intermolt than the premolt crabs. In the hepatopancreas, CasEcR expression showed a peak at ZT9 in premolt crabs. Exogenous melatonin (10−7 mol/animal) reduced the expression of both genes in the eyestalk at ZT17. In the hepatopancreas, melatonin markedly increased the expression of the CasEcR gene at ZT9. Taken altogether, our results are pioneer in demonstrating the daily oscillation of gene expression associated to molt cycle stages, as well as the daily ecdysteroid and melatonin levels and the remarkable influence of melatonin on the molt cycle of C. sapidus.
The Mediating and Buffering Effect of Creativity on the Relationship Between Sense of Place and Academic Achievement in Geography
Authors: Zhang Jianzhen , Ge Jiahao , Ma Yuting , Wang Ziyang , Yu Yuyao , Liang Xiaoyu , An Zhenni , Xu Yanhua 
Published: June 2022

PurposeThis study explored the relationship between sense of place and academic achievement in geography and used a mediation model to verify the mediating role of creativity in this relationship.MethodsA total of 1,037 upper secondary school students were surveyed using theSense of Place Scale, theInnovative Behavior Scale, and theirgeography test scores. SPSS (version 26.0) was used for descriptive statistical analysis and correlation analysis. The PROCESS plug-in (version 4.0) was used to test the mediating effect of creativity.Results(1) The correlation analysis showed that sense of place has a positive effect on academic achievement in geography and is related to creativity. Moreover, creativity exerts a positive effect on academic achievement in geography (2). The results of mediation analysis indicated that creativity plays mediating and buffering roles in the relationship between sense of place and academic achievement in geography after controlling for gender and residential address. The direct and indirect effects accounted for 65.708 and 34.292% of the total effect, respectively.ConclusionsThe results indicated that sense of place affected not only academic achievement in geography directly but also creativity indirectly. This conclusion provides certain ideas for the development of geography curriculums. Since academic achievement in geography is related to both sense of place and creativity, it is necessary to pay more attention to integrating sense of place in geography education and to foster creativity in curriculum development and teaching of geography.
Association Between MTHFR rs17367504 Polymorphism and Major Depressive Disorder in Taiwan: Evidence for Effect Modification by Exercise Habits
Authors: Hsieh Ming-Hong , Nfor Oswald Ndi , Ho Chien-Chang , Hsu Shu-Yi , Lee Chun-Te , Jan Cheng-Feng , Hsieh Pao-Chun , Liaw Yung-Po 
Published: June 2022

Background/AimRecent studies reported that folate supplementation has beneficial effects on major depression. The Methylenetetrahydrofolate reductase (MTHFR) enzyme is crucial in folate metabolism. This population-based study examined the association between MTHFR rs17367504 polymorphism and major depressive disorder based on exercise habits.MethodsTaiwan Biobank (TWB) provided demographic and genotype data between 2008 and 2015. The biobank participants were Taiwanese aged 30 to 70. Data on major depressive disorder (MDD) were obtained from the National Health Insurance Research Database (NHIRD).ResultsA total of 636 individuals were identified with MDD, whereas 17,298 individuals were considered controls. The associations of MTHFR rs17367504 and exercise with MDD risk were estimated using logistic regression models. The distribution of MTHFR rs17367504 genotype frequencies differed significantly between the MDD and control groups. We found that, compared with the AA genotype, the GG genotype was associated with a significantly increased risk of MDD [adjusted odds ratio (aOR), 1.76; 95% confidence interval (CI), 1.05–2.94; p = 0.033]. We found an interaction (p = 0.04) between rs17367504 and exercise, a well-known protective factor for MDD. A substantial increase in the risk of MDD was found among those with GG genotypes who did not exercise (aOR, 2.93; 95% CI, 1.66–5.17; p &lt; 0.001).ConclusionsOur findings indicate that MDD is related to MTHFR rs17367504 and exercise, though the mechanisms remain to be determined.
A 3-Dimensional Printed Patient-Specific Surgical Guide to Facilitate Transsphenoidal Hypophysectomy in Dogs
Authors: Escauriaza Leticia , Fenn Joe , McCue John , Roper Darren , Vandenberghe Helene , Nye George , Oxley Bill , Granger Nicolas 
Published: June 2022

ObjectiveHypophysectomy in dogs is a difficult surgery that requires specific learning and training. We aimed to evaluate the accuracy of a 3-dimensional printed patient-specific surgical guide to facilitate choosing the entry point in the basisphenoid bone before approaching the sella turcica during transsphenoidal hypophysectomy in dogs.MethodsTwo canine cadavers and 8 dogs undergoing transsphenoidal hypophysectomy for Cushing's disease treatment, involving design and fabrication of a 3-dimensional printed guide. The ideal entry point in the basisphenoid bone outer cortical layer was determined in each dog pre-operatively; its anatomical location was described with a set of measurements then compared to post-operative computed tomography measures describing the location of the outer cortical window created in the basisphenoid bone.ResultsSeveral guide designs were proposed, and a consensus reached based on surgeons' experience performing hypophysectomy. The device chosen could be applied to the size and shape of skulls encountered in this case series. The pre-planned measurements were comparable to post-operative measurement (there was also no statistical difference), with median of differences &lt;0.1 mm, which we judged as clinically acceptable.Clinical SignificanceHypophysectomy in dogs is a challenging procedure that has a learning curve and needs to be performed by specialist neurosurgeons. We propose that a low-profile 3-dimensional printed surgical guide can aid the specialist neurosurgeon to locate the burring site of the outer cortical layer of the basisphenoid bone at a pre-defined location and with good accuracy. It does not alleviate the need to understand the anatomy of the region and to know how to create a slot within the basisphenoid bone, which remains essential to enter the sella turcica. This device could help specialist veterinary neurosurgeons wishing to be trained to perform hypophysectomy.
Limited-Angle CT Reconstruction with Generative Adversarial Network Sinogram Inpainting and Unsupervised Artifact Removal
Authors: Xie En , Ni Peijun , Zhang Rongfan , Li Xiongbing 
Published: June 2022

High-quality limited-angle computed tomography (CT) reconstruction is in high demand in the medical field. Being unlimited by the pairing of sinogram and the reconstructed image, unsupervised methods have attracted wide attention from researchers. The reconstruction limit of the existing unsupervised reconstruction methods, however, is to use [0°, 120°] of projection data, and the quality of the reconstruction still has room for improvement. In this paper, we propose a limited-angle CT reconstruction generative adversarial network based on sinogram inpainting and unsupervised artifact removal to further reduce the angle range limit and to improve the image quality. We collected a large number of CT lung and head images and Radon transformed them into missing sinograms. Sinogram inpainting network is developed to complete missing sinograms, based on which the filtered back projection algorithm can output images with most artifacts removed; then, these images are mapped to artifact-free images by using artifact removal network. Finally, we generated reconstruction results sized 512×512 that are comparable to full-scan reconstruction using only [0°, 90°] of limited sinogram projection data. Compared with the current unsupervised methods, the proposed method can reconstruct images of higher quality.
Green Synthesis of Antibacterial Nanocomposite of Silver Nanoparticle-Doped Hydroxyapatite Utilizing Curcuma longa Leaf Extract and Land Snail (Achatina fulica) Shell Waste
Authors: Fatimah Is , Hidayat Habibi , Purwiandono Gani , Khoirunisa Khoirunisa , Zahra Hasna Azizah , Audita Rahmania , Sagadevan Suresh 
Published: June 2022

Preparation of green synthesized silver nanoparticle (AgNPs)-doped hydroxyapatite (Ag/HA) utilizing Curcuma longa leaf extract and land snail (Achatina fulica) shell waste was performed. Physicochemical characteristics and antibacterial activity of Ag/HA composite as a function of Ag content was studied. Instrumental analysis such as XRD, SEM-EDX, TEM, and XPS were employed to characterize the nanocomposites. The physicochemical study revealed the maintained porous structure of HA after Ag immobilization, and from TEM analyses, it was found that the distributed spherical particles are associated with the dispersed Ag and have a particle diameter of around 5–25 nm. Antibacterial activity of the nanocomposite was evaluated against Escherichia coli, Staphylococcus aureus, Kliebsiella pneumonia, and Streptococcus pyogenes. The results showed that the varied Ag content (1.0; 1.6; and 2.4% wt) influenced the nanoparticle distribution in the nanocomposite and enhanced the antibacterial feature.
Use of direct oral anticoagulants in primary care: a qualitative study integrating patient and practitioner perspectives
Authors: Osasu Yeyenta Mina , Mitchell Caroline , Cooper Richard 
Published: June 2022

BackgroundOlder patients with atrial fibrillation (AF) are increasingly offered direct oral anticoagulants (DOACs) to reduce the risk of catastrophic stroke, but clinical follow-up and compliance checks are still required to maintain patient safety. Although a recent qualitative meta-analysis has explored up-to-date research in this area, little is known qualitatively about clinicians’ or patients’ views and experiences of DOAC use in primary care in the UK.AimTo understand the experiences of healthcare practitioners and patients in relation to DOAC use in UK primary care.Design & settingSemi-structured interviews were undertaken. Sixteen older patients with AF taking DOACs, 10 pharmacists, and six GPs were interviewed in Sheffield, England in 2018.MethodInterview questions were developed following a systematic literature review. Interviews were audio-recorded, transcribed, and analysed using six-stage thematic analysis.ResultsThe integrated perspectives show that all three participant groups preferred DOACs over warfarin, a preference driven mainly by the safety profile compared with warfarin. GPs valued pharmacists' input in anticoagulant care, and pharmacists discussed patient safety in the context of anticoagulant audits, and highlighted the need for continuous patient education and counselling. Medication reviews by pharmacists were seen as a positive contribution to medicines optimisation.ConclusionPatients had an overriding trust in their doctors. GPs valued a collaborative approach with other clinicians, and community pharmacists appeared to highlight operational challenges in primary care that may limit the effectiveness of interventions.
ASUHAN BERPUSAT PADA KELUARGA MENINGKATKAN DUKUNGAN KELUARGA DAN KEBERHASILAN PEMBERIAN ASI AWAL
Authors: Supliyani Elin , Handayani Ina , Suhartika Suhartika 
Published: June 2022

ABSTRAK
Capaian ASI eksklusif di Indonesia belum mencapai angka yang diharapkan. Menurut data Riskesdas tahun 2018 alasan utama kegagalan pemberian ASI pada bayi 0-5 bulan adalah 68,3 % karena ASI tidak keluar. Proses menyusui akan berjalan optimal jika kondisi fisik dan psikologis ibu dalam keadaan baik. Dukungan keluarga merupakan faktor dominan yang mempengaruhi keberhasilan pemberian ASI. Dukungan dari orang terdekat sangatlah berperan dalam sukses tidaknya menyusui. Model asuhan yang berpusat pada keluarga diperlukan sebagai upaya untuk meningkatkan dukungan dalam memberikan ASI. Tujuan penelitian untuk menganalisa pengaruh model asuhan berpusat pada keluarga terhadap dukungan keluarga dan keberhasilan pemberian ASI awaL. Desain penelitian menggunakan pre-test post-test control group design, dilakukan di Praktik Mandiri Bidan Kota Bogor. Pengambilan sampel dilakukan secara purposive sampling terhadap 27 responden kelompok intervensi dan 27 kelompok kontrol. Variabel diukur menggunakan instrumen pre-test post-test sebelum dan setelah diberikan perlakuan asuhan kepada keluarga ibu hamil berupa edukasi pentingnya ASI, adaptasi psikologis ibu nifas, pijat oksitosin, cara dan posisi menyusui. Evaluasi asuhan kepada keluarga dilihat dari dukungan yang dirasakan ibu dan keberhasilan pemberian ASI sampat 7 hari postpartum. Analisa pengaruh model asuhan berpusat pada keluarga terhadap dukungan menggunakan uji Mann-Whitney, sedangkan untuk menganalisa pengaruh asuhan terhadap pemberian ASI awal menggunakan uji Chi-Squre. Hasil menunjukkan bahwa terdapat pengaruh yang bermakna model asuhan berpusat pada keluarga terhadap dukungan dan keberhasilan pemberian ASI awal (p<0.001) dan (p =0.017). Diharapkan model asuhan berpusat pada keluarga ini dapat diaplikasikan sebagai model dalam memberikan asuhan kepada ibu hamil agar mendapat dukungan dari keluarga dan berhasil memberikan ASI.

Kata Kunci : Asuhan berpusat pada keluarga, Dukungan keluarga, Pemberian ASI
Specificity, Sensitivity and Usefulness Of Neutrophil Lymphocyte Ratio In The Follow-Up Of Patients After Helicobacter Pylori Eradication Treatment
Authors: YILMAZ Gökhan , YİĞİT Ece 
Published: June 2022

Objective: The aim of this study is to determine the sensitivity and specificity of the NLR ratio in order to assess treatment effectiveness in the follow-up of patients who are endoscopic H. pylori-positive and administered eradication therapy.
Materials and Methods: The Endoscopy Unit at Istanbul Medipol University Pendik Hospital evaluated 386 individuals who underwent upper gastrointestinal endoscopy. Neutrophil and lymphocyte counts, as well as neutrophil-to-lymphocyte ratios (NLR), were compared in HP positive and negative patients. H. pylori eradication was performed on 205 HP-positive patients using a 2-week triple therapy. All patients had a complete blood count done at the same time, and NLR was computed and compared between the eradicated and non-eradicated groups.
Results: H. pylori eradication was accomplished in 100 (48.7%) of the patients, whereas the stool antigen test was positive in 105 (51.3%) of the patients. There was a statistically significant difference in neutrophil counts (P
Association Between Index of Cardio‐Electrophysiological Balance and Cardiac Remodeling
Authors: DURAN Mustafa , ÖZEN Mehmet Burak , BÜYÜKTERZİ Zafer 
Published: June 2022

Objective: Pathophysiological changes in response to myocardial infarction (MI) result in cardiac remodeling. Left untreated this pathologic process contributes to impairment of ventricular function and development of malignant ventricular arrhythmias. Recently introduced ECG‐based marker index of cardio‐electrophysiological balance (iCEB) has been shown to be associated with various cardiac conditions. Herein, we aimed to investigate the association between the iCEB and cardiac remodeling in post-MI patients.
Materials and Methods: Patients aged ≥18 years presenting with acute MI who underwent successful percutaneous coronary intervention between January 2020 and January 2021 were recruited. Regarding the assessment of cardiac remodeling, left ventricular (LV) mass, LV mass index (LVMI), and relative wall thickness (RWT) were measured before the start of treatment and six months after the procedure along with the QT/QRS ratio (iCEB), and QTC/QRS ratio (iCEBc).
Results: According to our study, estimated QT/QRS (iECB) and QTc/QRS (iECBc) ratios were found to be significantly lower at six-month follow-up compared to baseline values (4.73∓0.60 vs 4.62∓0.55 & 4.93∓0.59 vs 4.78∓0.55, p
Is Elderly-Onset Rheumatoid Arthritis Different From Younger-Onset Rheumatoid Arthritis?
Authors: DURMAZ Yunus , İLHANLI İlker , USTUN CETİNKAYA Betul , CENGİZ Kıvanç 
Published: June 2022

Objectives: To compare elderly-onset rheumatoid arthritis (EORA) patients with younger-onset rheumatoid arthritis (YORA) patients in terms of sociodemographic, clinical and radiological features, and treatment responses.
Materials and Methods: 422 rheumatoid arthritis (RA) patients were evaluated retrospectively. Patients with the age of onset of disease symptoms ≥60 were considered EORA, and those 0.05).
Conclusion: There is no difference in many clinical and laboratory findings, especially disease activity scores and radiographic scores, in patients with EORA and YORA.
Çocuklarda Helicobacter pylori Enfeksiyonunda Risk Faktörleri ve Klinik Bulgular
Authors: ERDEMİR Gülin , ÖZKAN Tanju , ÖZGÜR Taner , ARSOY Hanife Ayşegül , ÇAKAR Sevim 
Published: June 2022

Giriş ve Amaç: Helicobacter pylori(H.pylori) enfeksiyonu tüm dünyada en yaygın kronik enfeksiyonlardan biridir. Gelişmekte olan ülkelerde bulaş genellikle çocukluk döneminde olmaktadır. Düşük sosyoekonomik seviyede yaşayanlarda daha sık görülmektedir. Tamamen asemptomatik olabileceği gibi, gastrointestinal ve ekstraintestinal semptomlarla karşımıza çıkabileceği de bilinmektedir. Bu çalışmada çocuklarda H.pylori seroprevalansının saptanması, risk faktörleri ve semptomların değerlendirilmesi amaçlanmıştır.
Gereç ve Yöntemler: Çalışmaya Bursa ilinde beş farklı ilköğretim okulundan randomizasyonla 6-16 yaş arası 489 öğrenci alındı. Kabul eden ailelerden sosyoekonomik bilgileri ve çocuklarındaki semptomları sorgulayan anketleri doldurmaları istendi. Okullara gidilerek çocukların antropometrik ölçümleri yapıldı. H.pylori İmmunglobulin G (IgG) çalışılmak üzere çocuklardan 5 ml kan örneği alındı. Çocuklar H.pylori IgG pozitifliğine göre 2 gruba ayrılarak sosyoekonomik özellikler ve semptomlar karşılaştırıldı.
Bulgular: Çalışmaya 489 öğrenci alındı, %48,7 kız ve %51,3 erkekti. Yaş ortalaması 9,9±2,3 yıldı. H. pylori seropozitifliği %44 çocukta saptandı. Kızların %52,1’i, erkeklerin %36,3’ü seropozitif bulundu (p=0,0001). Sosyoekonomik faktörlerden babanın eğitim düzeyi azaldıkça çocukta H. pylori sıklığının arttığı saptandı (p=0,005). H. pylori seropozitif olanlarda boy ve vücut ağırlığı Z skorları negatif olanlara göre anlamlı olarak düşüktü (p=0,012 ve p=0,03;sırasıyla). Yaş gruplarına göre bakıldığında H.pylori seropozitiflerde 6-10 yaşta vücut ağırlığının ( p=0,03), 10 yaşından büyüklerde ise boy uzunluğunun (p=0,04) daha geri olduğu saptandı.
Sonuç: Bursa ilinde ilköğretim çağında saptanan H.pylori seropozitivite sıklığı Türkiye verileri ile uyumludur. Vücut ağırlığı ve boy uzunluğunun seropozitiflerde daha geri olduğu görülmüştür. Seropozitivitenin 10 yaştan küçük çocuklarda vücut ağırlığını, 10 yaştan büyük olanlarda ise boy uzunluğunu ön planda etkilediği görülmüştür. Sonuç olarak çocuklarda H.pylori, bulaş sonrası asemptomatik kalabilen ancak çocuklarda büyümeyi olumsuz etkilediği unutulmaması gereken önemli bir faktördür.
LİPÖDEMDE SUBKÜTAN YAĞ DOKUSU KALINLIĞI İLE ADİPOKİNLER ARASINDAKİ İLİŞKİ
Authors: ÜNLÜ Zeliha , ÇAVUŞOĞLU Tuğba , KOSOVA Funda , AYDIN Ali 
Published: June 2022

Giriş ve Amaç: Adipokinler ve disfonksiyonel yağ dokusu arasındaki ilişkide subkutan yağ dokusundan ziyade viseral yağ dokusundaki değişikliklerin rolüne dikkat çekilmiştir. Özellikle cilt altı yağ dokusunun etkilendiği lipödemde adipokinler hakkında bilgi yetersizdir. Bu çalışmada lipödemli hastalarda adiponektin, ghrelin, resistin ve visfatin düzeylerinin ve bunların yağ doku kalınlığı ile ilişkisinin araştırılması amaçlandı. Bu amaçla cilt altı yağ dokusu kalınlığı ultrasonografi ile objektif olarak değerlendirildi.
Gereç ve Yöntemler: Lipödem tanısı almış toplam 19 kadın hasta ve yaş farkı olmayan 15 sağlıklı kadın çalışmaya dahil edildi. Deri ve deri altı yağ dokusu kalınlıkları ultrasonografik olarak ölçüldü. Tüm deneklerin serum adiponektin, ghrein, resistin ve visfatin seviyeleri sandviç ELISA protokolü kullanılarak ölçüldü.
Bulgular: Lipödemli hastalarda, uyluk ve baldırda subkutan subkutan doku kalınlığı ve toplam deri-subkutan kalınlığı kontrollere kıyasla, uyluktaki deri kalınlığı dışında önemli ölçüde arttı (P0.05). Lipödemli hastalarda ve kontrollerde ultrason ile adiponektin, ghrelin, resistin ve visfatin ile deri, deri altı ve toplam kalınlık ölçümleri arasında anlamlı bir ilişki bulunmadı (P>0.05). İstatistiksel olarak anlamlı olmasa da detaylı incelendiğinde adipokinler ve ultrason ölçümleri arasındaki ilişkide gruplar arasında pozitif veya negatif korelasyonlar gözlendi.
Sonuç: Bulgularımıza göre, serum adipokin düzeyleri ile deri altı yağ dokusu kalınlığı arasında anlamlı bir ilişki bulunmamakla birlikte, tamamen ilgisiz oldukları tartışmalıdır. Daha geniş serilerde yapılacak çalışmalar adipokinlerin cilt altı doku kalınlığı ile ilişkisine ve ultrasonografinin önemine ışık tutacaktır.