bluuebunny/crossref_metadata_2025_split huggingface dataset:
STUDI TENTANG KOMPETENSI PROFESIONAL GURU DAN HASIL BELAJAR SISWA SMK BIDANG KEAHLIAN BISNIS DAN MANAJEMEN DI KOTA BANDUNG
Authors: Arfah Minati , Muhidin Sambas Ali 
Published: August 2022

Hasil belajar siswa dipengaruhi oleh banyak faktor baik faktor internal maupun faktor eksternal. Salah satu faktor yang mempengaruhi hasil belajar siswa adalah guru, karakteristik yang dimiliki guru khususnya kompetensi profesional guru merupakan faktor yang paling menentukan hasil belajar siswa. Kompetensi profesional merupakan salah satu kompetensi yang harus dimiliki oleh guru, yang mana diharapkan profesionalisme guru dapat meningkatkan mutu pendidikan. Sekaitan dengan hal tersebut, penelitian ini hendak mengkaji hubungan kompetensi profesional guru dan hasil belajar siswa yang dilakukan pada 5 SMK swasta di kota Bandung. Penelitian ini menggunakan metode survei dan data dikumpulkan melalui kuesioner yang diberikan kepada 29 orang guru SMK bidang keahlian Bisnis dan Manajemen. Data dianalisis melalui teknik analisis data korelasi rank spearman, yaitu untuk mengetahui apakah terdapat hubungan yang signifikan antara kompetensi profesional guru dengan hasil belajar siswa. Dari hasil kajian ini, menunjukkan bahwa terdapat hubungan antara kompetensi profesional guru dengan hasil belajar siswa SMK bidang keahlian Bisnis dan Manajemen pada 5 SMK swasta di kota Bandung
Physico-chemical profile of historical Ramala Water Reservoir of Chandrapur Maharashtra
Authors: Chilke Arun , Khinchi Pruthviraj 
Published: August 2022

Ramala water reservoir is located in the heart of Chandrapur city constructed by Gond king around 600 years back with the purpose to provide water to the citizens for various uses. However, at present, the condition of this reservoir is much pathetic which leads not only to the death of the fishes but the posing threat to the citizens' health. Therefore, the present work was carried out to find out the physico-chemical perspective of this lake. This study is experimental in nature. The Ramala water reservoir was the subject of study. The water samples were collected once in the middle of the month from November 2020 to March 2021. Almost all parameters except phosphate and nitrate were shown to contain under the permissible limit and indicate water may be consumed. The boom in aquatic vegetation is observed due to a high degree of eutrophication. It has been concluded through the study that the water under study is useful for human consumption and also for fisheries.

Keywords: Eutrophication; physico-chemical; pollution; water; WQI.
Prediction of outcomes for symptomatic spinal cavernous malformation surgery: a multicenter prospective clinical study
Authors: Huang Qiang , Liu Tong , Wang Lichao , Zhang Shizhong , Han Hao , Du Kangjie , Chen Xin , Zhao Zilong , Zhao Liwen , Xie Jiapeng , Zhao Lu , Peng Zhijun , Zhu Tao 
Published: August 2022

Abstract
Objective: Clinical outcome of spinal cavernous malformation (SCM) varies because of its unclear natural history and reliable prognostic prediction model for SCM patients is limited. The aim of the present study was to investigate potential factors that predict one year neurological status in postoperative patients with SCM.Methods: This was a multicenter prospective observational study in consecutive patients with SCMs. SCMs treated microsurgically between January 2015 and January 2021 were included. Outcome was defined as Frankel Scale (ranging from A to E) at one year after operation. Multivariable analyses were used to construct the best predictive model for patient outcomes.Results: We identified 268 eligible SCM patients. Neurological outcome had worsened from preoperative baseline in 51 patients (19.0%) at one year. In the multivariable logistic regression, the best predictive model for unfavorable outcome included symptom duration ≥ 26 moths (95% CI: 2.80-16.96, P < 0.001), size ≤5 mm (95% CI: 1.43-13.50, P = 0.010), complete intramedullary (95% CI: 1.69-8.14, P = 0.001), subarachnoid hemorrhage (95% CI: 2.92-12.57, P < 0.001), Frankel Grade B (95% CI: 1.91-40.93, P = 0.005) and Frankel Grade C (95% CI: 1.12-14.54, P = 0.033).Conclusions: Admission size of the lesion, morphology, symptom duration, Frankel Grade and the presence of subarachnoid hemorrhage were strong outcome predictors regarding prognostication of neurological outcome in postoperative patients with SCMs. A decision to surgically remove a symptomatic SCM should be justified by systematic analysis of all factors potentially affecting outcome.
Higher Reinfection Rate after Two-stage Revision Arthroplasty in Patients with Refractory Diabetes Mellitus: A retrospective analysis with a minimum ten-year follow up
Authors: Lin Yu-Chih , Lin Yi-Hsuan , Chou Jian-Hong , Lo Yu-Tai , Chang Chih-Hsiang , Lee Sheng-Hsun , Lin Sheng-Hsuan 
Published: August 2022

Abstract
Background: Treatment protocols for two-stage revision arthroplasty with diabetes mellitus (DM) have not yet been established. The control of glycated hemoglobin (HbA1c) in two-stage revision arthroplasty is still debated. This study aimed to clarify the importance of preoperative HbA1c levels before each stage of revision arthroplasty and to analyze the risk factors for reinfection.Methods: 588 patients suffered from first-time PJI and was treated in our institute from January 1994 to December 2010 were reviewed. The mean follow-up time was 13.8 (range, 10.2–24.8) years. Patients underwent two-stage revision arthroplasty with DM at presentation were included. The endpoint of the study was reinfection of the revision arthroplasty. Demographic, survivorship, and surgical variables were also analyzed.Results: Eighty-eight patients were identified and grouped by HbA1c level before the first stage surgery: Groups 1 and 2 had HbA1c levels < 7% and ≥ 7%, respectively. Reinfection was identified in 4.55% (2/44) and 18.18% (8/44) of the patients in Groups 1 and 2, respectively. Survivorship analysis revealed correction of the HbA1c before the final stage of revision arthroplasty as an independent factor (p < 0.001). The identified risks for reinfection were HbA1c levels ≥ 7% before final-stage surgery, ≥ 3 stages of revision arthroplasty, and extended-spectrum beta-lactamase (ESBL)-Escherichia coli PJI.Conclusion: The HbA1c level before the final stage of revision arthroplasty could affect staged revision arthroplasty outcomes. Therefore, the necessity of postponing the elective final-stage revision arthroplasty procedure for HbA1c control should be further investigated in the future.
D-beta-hydroxybutyrate exhibits protective effects against microglia activation in lipopolysaccharide-treated mice and BV-2 cells
Authors: Zhang Yuping , Liu Kun , Li Yunpeng , Ma Yujie , Wang Yu , Fan Zihan , Li Yanning , Qi Jinsheng 
Published: August 2022

AbstractMicroglia activation is the key player in neuro-inflammation, which is the central process of neuro-disorders. The protective effects of D-beta-hydroxybutyrate (BHB) against microglia activation were evaluated in lipopolysaccharide (LPS)-treated mice and BV-2 cells. Behavioral test, morphological change and immunofluorescence of microglia marker ionizing calcium-binding adaptor molecule 1 (IBA-1) in the hippocampus, and the generation of inflammatory interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α), and protective brain-derived neurotrophic factor (BDNF) and transforming growth factor-β (TGF-β) in the brain, were measured in LPS and/or BHB treated mice. In addition, the effects of BHB on the generation of IL-6, TNF-α, BDNF and TGF-β, and reactive oxygen species (ROS) level were detected in LPS-stimulated BV-2 cells. We found that BHB treatments attenuated behavioral abnormality of LPS-treated mice and reduced the number of IBA-1-positive cells with attenuation of cell morphological changes in the hippocampus. Meanwhile, BHB inhibited IL-6 and TNF-α generations; but promoted BDNF and TGF-β generations in the brain in LPS-treated mice. Furthermore, BHB concentration-dependently inhibited IL-6 and TNF-α generations, promoted BDNF and TGF-β generations, and reduced the level of reactive oxygen species with attenuation of cellular changes in LPS-stimulated BV-2 cells. In conclusion, BHB exhibits protective effects against microglia activation in LPS-treated mice and BV-2 cells, antagonizing neuro-inflammation.
Hybrid Intelligent Security Mechanism for Data Transmission among UPFs belonging to Different 5G Networks
Authors: Leu Fang-Yie , Lu Yu-Syuan , Liu Jung-Chun , Lin I-Long , He Rong-Tao , Dai Ning-Qi 
Published: August 2022

Abstract
Recently, 5G networks have gradually surrounded our living environments to color our everyday lives and make our daily activities more convenient than before. However, in 5G networks, packet P transmitted from local UPFA of a 5G network, e.g., 5G-A, to UPFB in P’s destination 5G network, e.g., 5G-B, is not secure, even not encrypted, particularly via the Internet, A ≠ B. This conducts a risk of data leakage along the connection established between UPFA and UPFB. To solve this problem, in this study, we propose an architecture that encrypts/decrypts P to prevent it from being attacked. P is encrypted by an edge computer, e.g., ECA in 5G-A before it is sent to its destination, and decrypted by another edge computer, e.g., ECB in 5G-B. In this paper, the scenario includes data transmission between two users or among n-party users, n > 2. For the former, the cryptography systems used are symmetric and asymmetric encryption/decryption approaches. For the n-party scheme, we adopt Initial Key Agreement (IKA) mechanism which employs Upflow and Downflow processes to establish a secret key for all participating ECs. Besides, message authentication code, and time stamp are also utilized to enhance the security level of data transmission. Our analyses show that this proposed approach can effectively avoid some types of attacks.
Interfacial shear strength of surface functionalized and functionalized CNT coated carbon fiber: A single fiber fragmentation study
Authors: Gogoi Rupam , Shankar Uday , Rawat Shweta , Manik Gaurav , Bandyopadhyay Anasuya 
Published: August 2022

Abstract
In this study, an effective surface functionalization of carbon fiber (CF) and its subsequent coating with functionalized carbon nanotubes (CNTs) were carried out to obtain improved interfacial shear strength (IFSS) which was validated by single fiber fragmentation test (SFFT). Functional groups, -COOH, -OH, and -NH2, were separately grafted on the CF surface using different chemical routes. Additionally, ultrasonic assisted electrophoretic deposition (EPD) technique was used to coat -COOH, -OH, and -NH2 functionalized CNTs on the sized and surface functionalized CFs. Attenuated total reflection-infrared spectroscopy (ATRIR), X-ray photoelectron spectroscopy (XPS), and field emission scanning electron microscopy (FESEM) images confirmed the successful surface functionalization and coating on CF. Neat PP and a blend of PP and maleic anhydride-grafted-styrene ethylene butylene styrene (MA-g-SEBS) were used as two different base polymer matrixes in preparing a total of 26 different SFFT samples. Silane functionalized CF coated with amine functionalized CNTs using ultrasonic assisted EPD process showed IFSS of ~ 29 MPa which was an impressive ~ 758% higher than pristine CF and highest among all the surface modified CFs. Interestingly, this translated into useful increase of ~ 13% in single fiber tensile strength of functionalized and treated CF over and above that of as received CF.
Synthesis and assessment of the cytotoxic effects of some of Novel Biginelli 3,4-dihydropyrmidine-2-(1H) one derivatives Containing 2-mercapto-3-phenyl-4(3H)-quinazolinone.
Authors: Nouri Mojtaba , Pirmohammadi Nasim , dilmaghani karim akbari , Pazhang Yaghub 
Published: August 2022

Abstract
In the present study, a new series of 3,4- dihydropyrmidine2-(1 H) one derivatives(4a-f) which linked to 2-mercapto-3-phenyl-4(3H)-quinazolinone were synthesized by using the nucleophilic substitution reaction of 2-mercapto-3-phenyl-4(3H)-quinazolinone (1) and an appropriate 6-bromomethyl-3,4- dihydropyrmidine2-(1 H) one (3a-f) in the presence of KOH as base and in CH3CN as solvent. The chemical structures of the synthesized compounds were confirmed by means of IR, 1H-NMR, 13C-NMR, Mass spectroscopy, and Elemental analysis. The cytotoxicity of the newly synthesized compounds was evaluated in vitro against the human breast cancer (MCF-7) cell line and human colon cancer cell line (HT-29) based on the results of the MTT assay. Our results indicated that the compound 4b exerted the most cytotoxic effect in the two cell lines and the IC50 values were (4.25±0.16 μM) for MCF-7 cell lines and (12.11±0.76 μM) for HT-29 cell lines. Also, compound 4b induced apoptosis more than other compounds in the two cell lines. Therefore, compound 4b may be a potential anticancer agent.
Development of a novel lipid metabolism-based signature to predict survival and immune response in triple negative breast cancer
Authors: Yang Xia , Tang Wen , He Yongtao , An Huimin , Wang Jin 
Published: August 2022

Abstract
Background
The high heterogeneity of triple negative breast cancer (TNBC) is the main clinical challenge for individualized therapy. Considering that fatty acid metabolism (FAM) plays an indispensable role in tumorigenesis and development of TNBC, we proposed a novel FAM-based classification to characterize the tumor microenvironment immune profiles and heterogeneous for TNBC.
Methods
Weighted gene correlation network analysis (WGCNA) was performed to identify FAM-related genes from 221 TNBC samples in Molecular Taxonomy of Breast Cancer International Consortium (METABRIC) dataset. Then, non-negative matrix factorization (NMF) clustering analysis was applied to determine FAM clusters based on the prognostic FAM-related genes, which chosen from the univariate/multivariate cox regression model and the least absolute shrinkage and selection operator (LASSO) regression algorithm. Then, a FAM scoring scheme was constructed to further quantify FAM features of individual TNBC patient based on the prognostic differentially expressed genes (DEGs) between different FAM clusters. Systematically analyses were performed to evaluate the correlation between the FAM scoring system (FS) with survival outcomes, genomic characteristics, tumor microenvironment (TME) features and immunotherapeutic response for TNBC, which were further validated in the Cancer Genome Atlas (TCGA) and GSE58812 datasets. Moreover, the expression level and clinical significancy of the selected FS gene signatures were further validated in our cohort.
Results
1860 FAM-genes were screened out using WGCNA. Three distinct FAM clusters were determined by NMF clustering analysis, which allowed to distinguish different groups of patients with distinct clinical outcomes and tumor microenvironment (TME) features. Then, prognostic gene signatures based on the DEGs between different FAM clusters were identified using univariate cox regression analysis and Lasso regression algorithm. A FAM scoring scheme was constructed, which could divide TNBC patients into high and low-FS subgroups. Low FS subgroup, characterized by better prognosis and abundance with effective immune infiltration. While patients with higher FS were featured with poorer survival and lack of effective immune infiltration. In addition, two independent immunotherapy cohorts (Imvigor210 and GSE78220) confirmed that patients with lower FS demonstrated significant therapeutic advantages from anti-PD-1/PD-L1 immunotherapy and durable clinical benefits. Further analyses in our cohort found that the differential expression of CXCL13, FBP1 and PLCL2 were significantly associated with clinical outcomes of TNBC samples.
Conclusions
This study revealed FAM plays an indispensable role in formation of TNBC heterogeneity and TME diversity. The novel FAM-based classification could provide a promising prognostic predictor and guide more effective immunotherapy strategies for TNBC.
Extracellular vesicles from biological fluids as potential biomarkers for prostate cancer
Authors: Choi Wendy Y. , Sánchez Catherine , Li Jiao Jiao , Dinarvand Mojdeh , Adomat Hans , Ghaffari Mazyar , Khoja Leila , Vafaee Fatemeh , Joshua Anthony M. , Chi Kim N. , Guns Emma S. Tomlinson , Hosseini-Beheshti Elham 
Published: August 2022

Abstract
Purpose
Despite the high incidence of false positives, prostate specific antigen (PSA) screening remains a widely used diagnostic test for prostate cancer, driving an urgent need for the discovery of better biomarkers for early prostate cancer detection. Extracellular vesicles (EV) secreted from cancer cells are present in various biological fluids, carrying distinctly different cellular components compared to normal cells, and have great potential to be used as a source of biomarkers.
Methods
EV from serum and urine of healthy men and prostate cancer patients were isolated, and characterised by transmission electron microscopy, particle size analysis, and western blot. Proteomic and cholesterol liquid chromatography-mass spectrometry (LC-MS) analyses were conducted.
Results
There was a successful enrichment of exosomes isolated from serum and urine. EV derived from biological fluids of prostate cancer patients had significant differences in composition when compared with those from healthy controls. Analysis of matched serum and urine samples from six prostate cancer patients revealed specific EV proteins common in both types of biological fluid for each patient.
Conclusion
Some of the EV proteins identified from our analyses have potential to be used as prostate cancer biomarkers, either to depict cancer progression or for disease diagnosis through non-invasive testing.
EDUKASI GIZI BAGI IBU BALITA DI WILAYAH KERJA PUSKESMAS LAPAI KECAMATAN NANGGALO KOTA PADANG
Authors: Azrimaidaliza Azrimaidaliza , Femelia Welly , Chalida Nadia Nur , Putri Rahmi 
Published: August 2022

Permasalahan gizi pada balita menunjukkan kecenderungan peningkatan di Indonesia termasuk di kota-kota besar seperti Kota Padang. Salah satu permasalahan gizi tersebut adalah stunting. Kondisi stunting dapat berdampak pada tumbuh dan kembang anak pada usia berikutnya bahkan berisiko mengalami penyakit degeneratif pada usia dewasa. Tujuan kegiatan edukasi gizi pada ibu balita adalah untuk meningkatkan pengetahuan dan pemahaman ibu balita mengenai pentingnya 1000 Hari Pertama Kehidupan (HPK) dalam mengatasi permasalahan gizi balita. Kegiatan berupa penyuluhan langsung pada kelompok kecil mengenai 1000 HPK dan didukung dengan media leafleat. Sasaran kegiatan adalah ibu hamil dan ibu balita yang berkunjung ke salah satu Posyandu yang berada di Wilayah Kerja Puskesmas Lapai Kecamatan Nanggalo, Kota Padang. Mitra kegiatan ini adalah Puskesmas Lapai tepatnya bekerjasama dengan tenaga gizi dan tenaga kesehatan termasuk kader yang melaksanakan kegiatan di Posyandu di Puskesmas tersebut. Monitoring dan evaluasi keberhasilan kegiatan dinilai dari hasil pre dan post-test yang disampaikan kepada sasaran kegiatan. Kegiatan edukasi terlaksana dengan baik walaupun masih dalam suasana pandemi COVID-19 dan penerapan PPKM. Kegiatan ini dihadiri oleh 12 ibu balita, 2 orang kader dan 2 orang petugas kesehatan dari Puskesmas Lapai. Berdasarkan hasil pre dan post test diperoleh peningkatan pengetahuan baik ibu balita (66,7% menjadi 83,3%). Dengan demikian, kegiatan edukasi berupa penyuluhan melalui kerjasama institusi pendidikan dan institusi kesehatan agar dapat dilaksanakan melalui kegiatan Posyandu setiap bulannya untuk mencegah terjadinya permasalahan gizi pada balita.
PENGEMBANGAN EKONOMI MASYARAKAT MELALUI PROGRAM HIDROPONIK PERSPEKTIF MAQASHID SYARIAH DI KECAMATAN WONOCOLO
Authors: Amaliyah Een Rizki , Ansar Lukman 
Published: August 2022

Abstrak Artikel ini yang berjudul “Pengembangan Ekonomi Masyarakat Melalui Program Hidroponik Perspektif Maqashid Syariah di Kecamatan Wonocolo” ini merupakan hasil penelitian yang menjawab pertanyaan tentang Bagaimana pengembangan ekonomi masyarakat Kecamatan Wonocolo melalui program hidroponik perspektif maqashid syariah.Metodologi penelitian yang digunakan adalah kualitatif deskriptif dengan menggunakan metode wawancara. Dalam penelitian ini yang diwawancarai adalah tiga narasumber meliputi Ketua LPMK (Lembaga Pemberdayaan Masyarakat Kelurahan), Ketua RW 04 dan Ketua Kelompok Tani KRPL Serpis yang mendukung data-data penelitian.Hasil penelitian ini menyatakan bahwa tujuan dari program hidroponik adalah pengembangan masyarakat dengan melalui beberapa bentuk kegiatan, seperti pelatihan untuk menambah daya kreativitas anggota Kelompok Tani KRPL Serpis. Selain itu tujuan dengan diadakannya program hidroponik adalah agar menjadikan anggota kelompok tani mandiri dalam perekonomian. Hal ini dibuktikan dengan adanya laporan keuangan tiap bulan yang meliputi pencatatan hasil penjualan. Selain itu bentuk dari kreativitas anggota kelompok tani dibuktikan dengan adanya program pembuatan olahan makanan, minuman dan kerajinan kokedama yang hasil dari penjualan akan masuk dalam kas kelompok tani.Selanjutnya hasil analisis mengenai maqashid syariah dalam program ini bahwa unsur yang paling dilindungi adalah harta, akal dan jiwa. Perlindungan terhadap harta dalam program ini dibuktikan dengan adanya kegiatan ekonomi seperti menjual hasil panen yang bisa mencukupi kebutuhan anggota kelompok tani. Selanjutnya dalam perlindungan akal dalam program ini melalui kegiatan pelatihan yang bisa menambah kreativitas anggota kelompok tani. Dan yang terakhir yaitu unsur menjaga jiwa. Dapat diketahui bahwa Surabaya yang merupakan Kota metropolitan yang sesak dengan macam aktivitas, maka dengan adanya kebun hidroponik menambah tempat untuk bisa mengurangi rasa penat ketika berkunjung di kebun.