bluuebunny/crossref_metadata_2025_split huggingface dataset:
Нейроендокринна стрес-відповідь у новонароджених із ураженням нирок на тлі асфіксії
Authors: Loboda A.M. , Markevich V.Ye. 
Published: January 2022

Мета роботи. Вивчити нейроендокринну стрес-відповідь на основі дослідження динаміки інтерлейкіну-1β (ІЛ-1β) та кортизолу в сироватці крові протягом неонатального періоду у новонаро­джених із ураженням нирок на тлі асфіксії.Матеріали і методи. Обстежено 100 доношених новонароджених із ознаками ушкодження нирок: 50 дітей, які перенесли тяжку асфіксію, та 50 дітей із помірною асфіксією. Групу порівняння становили 20 малюків без асфіксії. Рівень інтерлейкіну-1β та кортизолу в сироватці визначали на 1-шу — 2-гу, ­7–8-му та 25–30-ту добу життя твердофазовим імуноферментним аналізом.Результати. У новонароджених із порушенням функції нирок на тлі асфіксії спостерігали підвищення рівня ІЛ-1β в сироватці, посилення кореляції між ним та кортизолом, що викликало зростання рівня останнього. Найвищий уміст кортизолу в сироватці спостерігали на 1-шу — 2-гу добу життя (505,28 ± 36,96 нмоль/л та 374,4 ± 11,36 нмоль/л у малюків, які перенесли тяжку та помірну асфіксію відповідно). Тривала цитокінова стимуляція кори надниркових залоз у випадку тяжкої асфіксії призводила до зміни характеру кореляції (–0,328, p < 0,05) та виснаження продукції кортизолу наприкінці нео­натального періоду.
Determination of Optimization of Nutritional Deficiencies in Plant Physiology Practicum in Hydroponic Laboratories (Axis and No-Axis System)
Authors: Sumiati  , M. Akmal Surur  
Published: January 2022

Background: Hydroponics is a method of agriculture that utilizes water as a planting medium. The purpose of the study was to find out good working procedures and nutrient solution formulas capable of showing symptoms of morphological nutritional deficiencies in plants. Methods: The plants used are the seeds of kale plants that are sown within 1 - 2 weeks (until roots, stems, and leaves grow). The design used is Random Group using three formulas with nine kinds of treatment on each formula and three repeats. Experiments were conducted on two hydroponic systems, the axis and without the axis. The parameters observed are the number of leaves, the leaves' length, the leaves' width, the plant's height, and the plant's height. Results: Observational data in the analysis using SPSS 25. The effect of treatment with test parameters is seen using ANOVA analysis and BNT advanced tests. Visual observations showed the formula of nutrient solutions 1, 2 and 3 using both the axis system and without the axis showed symptoms of nutritional deficiencies in kale plants. The axis less system experiment gave more significant results on all parameters except PD (leaf length) than the axis system based on the average results of BNT advanced tests. Conclusion: Nutrient solutions 1, 2 and 3 have a real effect on all test parameters.
The relationship of clinical and anamnestic characteristics of patients with classical trigeminal neuralgia with the anatomical characteristics of neurovascular conflict
Authors: Bakunovich A. V. , Sinitsyn V. E. 
Published: January 2022

Introduction. Classical trigeminal neuralgia (TN) is a common disease, largely diagnosed by measuring the anatomical parameters of the trigeminal nerve and the adjacent artery using MRI. For an adequate assessment the significance of the identified changes, it may be necessary to adjust for the individual characteristics of the patient, such as gender, age, duration of the TN, and clinical severity of TN.The aim of the study was to identify the relationship of anatomical changes in the intercisternal portions of the trigeminal nerves and adjacent arteries with the clinical and anamnestic data of patients with classic trigeminal neuralgia.Materials and methods. The FIESTA MR sequences of 133 patients were analyzed: 86 patients with verified trigeminal neuralgia (55±11 years) and 47 patients of the control group (51±16 years). The cross-sectional areas (CSA) and diameter ratio of nerves, diameters of adjacent arteries and neurovascular distances were measured in the context of gender, age, duration and therapy of neuralgia.Results. After dividing the group of TN patients into three conditional age groups (up to 50 years old, 50–65 years old, and over 65 years old), the ANOVA analysis revealed a decrease in the CSA in older age groups (medians 3,2 mm2; 2,15 mm2; 1,85 mm2; p=0,0193) and an increase in the diameter of the adjacent artery (median 1 mm; 1,3 mm; 1,2 mm; p=0,018). At the same time, on the opposite sides of the TN, only a tendency towards a decrease in the CSA remained (median 4,45 mm2; 3,45 mm2; 3,05 mm2; p=0,0016). The CSA of the nerves in the operated patients were less than ones in the patients with conservative treatment (median 2,9 mm2 and 2 mm2; p<0,05). In patients with TN, right-sided lesion prevailed. The duration of the TN was 9±7,8 years (from 1 year to 33 years) for patients who had an accurately documented date of manifestation of TN (N=56), no direct correlations of the MR-parameters with the duration of TN were found. A simple correlation analysis between MR-parameters and the patients age revealed a linear relationship only for the decrease of the CSA: on the right side (p=0,014) in patients with TN and on both sides in control patients (р=0,005–0,013).Conclusion. Theas data make it possible to more clearly distinguish significant MR changes in TN, taking into account the clinical and anamnestic data of patients.The revealed MR patterns of an increase in the caliber of the adjacent artery and a decrease in the CSA, which are pathognomonic for a clinically significant neurovascular conflict, are often asymptomatic age-related changes in elderly patients, which reduces their potential diagnostic value. In connection with this circumstance, the comparison of seemingly significant anatomical changes with similar ones on the opposite side of the lesion is of exceptional importance.
- la noción del tiempo -
Authors: Venegas Romero Pablo 
Published: January 2022

Si miramos un tanto atrás, el tiempo aparentó detenerse en el espacio, como definiendo nuevas fronteras o configurando un tiempo imaginario3, sin embargo diciembre abre una ventana que nos regresa al futuro, recuperando una realidad que cada día se sentía más inasible. En este trayecto muchos trabajos persistieron, las investigaciones no se han detenido, por el contrario, se supieron sobrellevar a pesar de los intermedios4; así es como en este contexto, la contribución de los artículos aceptados para este número, continúa con un manifiesto valor desde la perspectiva de nuestro enfoque y alcance editorial, asumiendo la tarea de reflexionar y pensar el arte, y de visibilizar los métodos de pesquisa desarrollados en el contexto de procesos creativos.
Para el número actual recibimos trabajos profundos que contribuyen de manera significativa al desarrollo del conocimiento específico; el arte, la imagen y el sonido, las circunstancias contemporáneas, el teatro en gran medida, en esta ocasión terminan por armar el cuerpo del texto.
Uso de aromaterapia en gestantes: una revisión de la literatura
Authors: Angarita-Navarro Ariadna Maria , Casas-Cárdenas Paula Daniela , López-Aguirre Jineth Paola 
Published: January 2022

Introducción: Algunas mujeres, durante su gestación pueden padecer de sintomatología molesta que interfiere con su cotidianidad, molestias como náuseas, vómitos, dolores lumbares, y fluctuaciones emocionales. Tales molestias podrían manejarse con técnicas como la aromaterapia, propendiendo por ofrecer bienestar sin posibles efectos adversos para el binomio madre e hijo. El objetivo de este artículo es identificar los beneficios que produce la aromaterapia en la gestación mediante una revisión documental. Metodología: Se realizó una búsqueda de artículos científicos en bases de datos como: Science direct, google academic, EBSCO, Pubmed, Gale Power Search, BASE (Bielefeld academic search engine), Proquest; utilizando los DECS Aromatherapy, Pregnancy, Lavandula, Citrus, Jengibre y Rosa en inglés y español, usando el conector booleano AND, de esta búsqueda se obtuvo 50 artículos de investigación que cumplían con el objetivo propuesto. Resultados: se identificó la utilización de la aromaterapia como recurso para las náuseas, vómitos y el dolor, además de lograr mejorar el sueño y disminuir la fatiga. Conclusiones: Se determina entonces que los aceites esenciales usados en los estudios fueron eficaces disminuyendo síntomas molestos en la mayoría de las gestantes participantes de los estudios analizados
Análisis estadístico para la caracterización de los egresados del programa de arquitectura, diseño y urbanismo de la Universidad Francisco de Paula Santander
Authors: García-Martínez Ruth Stella , Díaz-Umaña Yannette 
Published: January 2022

Este articulo forma parte de la investigación a los egresados del Plan de estudio de arquitectura de la Universidad Francisco de Paula Santander (UFPS) desde la perspectiva estadística válida para determinar la caracterización de sus egresados desde la primera cohorte en 2005 hasta la última cohorte de 2020, del mismo modo busca conocer la incursión y el impacto en el medio laboral de los mismos, el estudio se realiza mediante un análisis estadístico descriptivo abordando aspectos como las condiciones socioeconómicas, el estado laboral, la formación en posgrados, los reconocimientos que han recibido. Los datos recabados ofrecen un recurso de evaluación y retroalimentación a fin de mejorar la formación de los nuevos profesionales y plantear estrategias que les permita satisfacer las necesidades reales de medio.
Investor Response to Bad News versus Good News Management Earnings Guidance
Authors: Josefy A. Bree , Rees Lynn , Tse Senyo 
Published: January 2022

SYNOPSIS
Prior research consistently reports stronger stock price responses to bad news management guidance than to good news guidance. Based on this result, several studies use the direction of guidance as a proxy for its credibility. We propose that managers opportunistically issue some small bad news guidance for the purpose of reducing earnings expectations to beatable levels. We expect investors to view small bad news guidance as less credible than small good news guidance. We find that investors respond less to small bad news guidance than to similar magnitudes of good news guidance. We show that investor skepticism is justified because small bad news guidance is generally less accurate than the prevailing consensus analyst forecast, whereas other guidance is typically more accurate than the prevailing consensus analyst forecast. Furthermore, the likelihood that bad news guidance is less accurate than the prevailing analyst forecast has increased since the mid-1990s.
Data Availability: Data are available from the public sources cited in the text.
JEL Classifications: D84; G10; M41.
Real-world Evidence of Efficacy and Safety of SGLT2 Inhibitors as Adjunctive Therapy in Adults With Type 1 Diabetes: A European Two-Center Experience
Authors: Palanca Ana , van Nes Falco , Pardo Felipe , Ampudia Blasco F. Javier , Mathieu Chantal 
Published: January 2022

OBJECTIVE
To evaluate real-world efficacy and safety of sodium–glucose cotransporter 2 inhibitor (SGLT2i) use in combination with insulin in people with type 1 diabetes.

RESEARCH DESIGN AND METHODS
We conducted a retrospective cohort European two-center study. Data on demographics, HbA1c, weight, insulin use, renal function, and adverse events were collected for 199 adults with type 1 diabetes who initiated a SGLT2i adjunct to insulin. Subgroup analyses were performed to identify who benefited most and who was more at risk for adverse events.

RESULTS
Overall, significant reductions in mean HbA1c (−0.5%), weight (−2.9 kg), and daily insulin (−8.5%) were achieved after 12 months. The greatest reduction in HbA1c was obtained in individuals with baseline HbA1c &gt;8% (−0.7% [64 mmol/mol]). The most weight loss was observed in subjects with BMI &gt;27 kg/m2 (−3.5 kg). Individuals with baseline estimated glomerular filtration rate (eGFR) &lt;90 mL/min/1.73 m2 showed an increase in eGFR (4.5 mL/min/1.73 m2), whereas those with urinary albumin-to-creatinine ratio (UACR) &gt;15 mg/g showed a decrease in UACR (−16.6 mg/g). Fifty-seven individuals (28.6%) reported adverse events: 45 with genital infections (22.6%), 5 ketosis episodes (2.5%), and 7 diabetic ketoacidosis (DKA) (3.5%). No severe hypoglycemia events were reported.

CONCLUSIONS
Our real-world data on SGLT2i showed promising results in reductions in HbA1c, weight, and insulin requirements in type 1 diabetes. Benefits were more pronounced in individuals with higher baseline HbA1c and BMI. DKA remained a major concern, despite educational measures. Further real-life evidence is still required for evaluation of SGLT2i longer-term effects and their impact on reno-cardiovascular outcomes.
Improvements in Awareness and Testing Have Led to a Threefold Increase Over 10 Years in the Identification of Monogenic Diabetes in the U.K.
Authors: Pang Lewis , Colclough Kevin C. , Shepherd Maggie H. , McLean Joanne , Pearson Ewan R. , Ellard Sian , Hattersley Andrew T. , Shields Beverley M. 
Published: January 2022

OBJECTIVE
Maturity-onset diabetes of the young (MODY) is a rare monogenic form of diabetes. In 2009, &gt;80% of U.K. cases were estimated to be misdiagnosed. Since then, there have been a number of initiatives to improve the awareness and detection of MODY, including education initiatives (Genetic Diabetes Nurse [GDN] project), the MODY probability calculator, and targeted next-generation sequencing (tNGS). We examined how the estimated prevalence of MODY and other forms of monogenic diabetes diagnosed outside the neonatal period has changed over time and how the initiatives have impacted case finding.

RESEARCH DESIGN AND METHODS
U.K. referrals for genetic testing for monogenic diabetes diagnosed &gt;1 year of age from 1 January 1996 to 31 December 2019 were examined. Positive test rates were compared for referrals reporting GDN involvement/MODY calculator use with those that did not.

RESULTS
A diagnosis of monogenic diabetes was confirmed in 3,860 individuals, more than threefold higher than 2009 (1 January 1996 to 28 February 2009, n = 1,177). Median age at diagnosis in probands was 21 years. GDN involvement was reported in 21% of referrals; these referrals had a higher positive test rate than those without GDN involvement (32% vs. 23%, P &lt; 0.001). MODY calculator usage was indicated in 74% of eligible referrals since 2014; these referrals had a higher positive test rate than those not using the calculator (33% vs. 25%, P = 0.001). Four hundred ten (10.6%) cases were identified through tNGS. Monogenic diabetes prevalence was estimated to be 248 cases/million (double that estimated in 2009 because of increased case finding).

CONCLUSIONS
Since 2009, referral rates and case diagnosis have increased threefold. This is likely to be the consequence of tNGS, GDN education, and use of the MODY calculator.
A randomized crossover study of compounded liquid sildenafil for treatment of generalized megaesophagus in dogs
Authors: Mehain Susan O. , Haines Jillian M. , Guess Sarah C. 
Published: January 2022

Abstract

OBJECTIVE
To determine whether delivery of compounded liquid sildenafil directly to the stomach of dogs with megaesophagus (ME) would affect esophageal clearance, regurgitation frequency, body weight, or quality of life.

ANIMALS
10 client-owned otherwise healthy dogs with stable ME.

PROCEDURES
A randomized crossover study was performed. Dogs received either sildenafil (1 mg/kg, PO, q 12 h) or a placebo for 14 days, followed by a 7-day washout period, then the opposite treatment for 14 days. Esophageal clearance time was assessed by means of videofluoroscopy prior to treatment and on day 1 of each treatment period. Owners maintained logs of regurgitation episodes and quality of life.

RESULTS
Compounded liquid sildenafil moved into the stomach during 21 of 30 (70%) videofluoroscopy sessions. Sildenafil resulted in a significant reduction in the number of regurgitation episodes (median, 3.5 episodes/wk; range, 0 to 14.5 episodes/wk), compared with baseline (median, 6.5 episodes/wk; range, 1.5 to 19.5 episodes/wk) and the placebo (median, 4 episodes/wk; range, 0 to 28 episodes/wk), and a significant increase in body weight (median, 22.05 kg; range, 6 to 26.3 kg), compared with baseline (median, 21.55 kg; range, 5.1 to 26.2 kg) and the placebo (median, 22.9 kg; range, 5.8 to 25.9 kg). There were no differences in esophageal clearance times or quality-of life-scores between sildenafil and placebo.

CLINICAL RELEVANCE
Although significant differences with placebo administration were identified, clinically relevant improvements were not seen with the use of compounded liquid sildenafil in dogs with ME.
A noninvasive method of temperature measurement using a noncontact handheld infrared thermometer fails to correlate with rectal temperature in dogs and cats
Authors: Barton James C. , Didier Martine D. , Silvestrini Paolo , German Alexander J. , Ferriani Riccardo 
Published: January 2022

Abstract

OBJECTIVE
To perform a retrospective, multicenter observational study that compares the agreement of rectal temperature with the temperature measured with noncontact infrared thermometer (NCIT) in a population of dogs and cats.

Animals
168 dogs and 61 cats.

PROCEDURES
NCIT readings were taken in triplicate from the medial pinna, then rectal temperature was taken with a standard digital rectal thermometer (RT). Ambient room temperature, signalment, presence of icterus, skin and coat color, reason for presentation, and final diagnosis were recorded.

RESULTS
In dogs, median (range) body temperature reflected by RT and NCIT measurements was 38.4 °C (33.4 to 40.3 °C) and 36.3 °C (30.8 to 40.0 °C), respectively. In cats, median (range) body temperature reflected by RT and NCIT measurements was 38.3 °C (36.2 to 40.0 °C) and 35.7 °C (31.8 to 38.0 °C), respectively. There was a weak positive correlation between body temperatures measured by NCIT and RT in dogs (Kendall tau = 0.154), but there was no correlation in cats (Kendall tau = –0.01). A significant, albeit weak, agreement was seen between temperature measured by NCIT and RT in dogs (Kappa value, 0.05), but not cats (Kappa value, –0.08). In both species, NCIT tended to underread body temperature, compared with RT (dogs: mean ± SD bias –2.2 ± 1.51 °C; cats: mean bias –2.7 ± 1.44 °C), with the degree of low measurements lessening as body temperature increased.

CLINICAL RELEVANCE
Given both poor correlation and agreement in body temperature measured by NCIT and rectal thermometer, NCIT measurements cannot be recommended at the current time as a means to determine body temperature in dogs and cats.
Discharge summaries provided to owners of pets newly diagnosed with cancer exceed recommended readability levels
Authors: Medland Julia E. , Marks Steven L. , Intile Joanne L. 
Published: January 2022

Abstract

OBJECTIVE
To analyze the readability of discharge summaries distributed to owners of pets newly diagnosed with cancer.

SAMPLE
118 discharge summaries provided to pet owners following initial consultation.

PROCEDURES
A database search identified records of new patients that had been presented to the North Carolina State Veterinary Hospital medical oncology service between June 2017 and January 2019. Owner-directed portions of the summaries provided at the time of discharge were copied and pasted into a document and stripped of all identifying information. Readability of summaries was assessed with the use of 2 previously established readability calculators: the Flesch-Kincaid Grade Level (FKGL) and Flesch Reading Ease (FRE) tests.

RESULTS
Mean ± SD FKGL was 11.9 ± 1.1 (median, 11.9; range, 8.6 to 15.5; target ≤ 6), and the mean ± SD FRE score was 43 ± 5.9 (median, 42.7; range, 25.5 to 58.1; target ≥ 60). There were no significant differences in FKGL or FRE scores among discharge summaries for patients with the 4 most common tumor types diagnosed or the described treatment options. Ninety-three percent (110/118) of summaries were scored as difficult or very difficult to read.

CLINICAL RELEVANCE
Owner-directed written information regarding a diagnosis of cancer at a single teaching hospital exceeded readability levels recommended by the American Medical Association and NIH and was above the average reading level of most US adults. Efforts to improve readability are an important component of promoting relationship-centered care and may improve owner compliance and patient outcomes.
Successful outcome of shell fractures in freshwater turtles treated with plate or screws and wire fixation techniques: 51 cases (2014–2019)
Authors: Patson Courtney N. , Lemley Erin M. , Smalley Eric W. , Doss Grayson A. , Mans Christoph 
Published: January 2022

Abstract

OBJECTIVE
To evaluate the outcome of surgical fixation of shell fractures in rehabilitated wild freshwater turtles.

ANIMALS
51 freshwater turtles with 86 shell fractures.

PROCEDURES
The medical record database of a wildlife rehabilitation center in Wisconsin was searched from 2014 through 2019 for records of freshwater turtles with shell fractures repaired with a plate technique, screws and wire technique, or both. Signalment, fracture location, therapeutic approach (including the type of hardware used for repair), dry-docking duration, time to hardware removal, postremoval care, and outcome were evaluated.

RESULTS
36 of 51 (71%) turtles with shell fractures experienced successful fracture healing following surgical hardware fixation, and 33 (65%) were released. Shells of 38 (75%) turtles were repaired with plates only, 5 (10%) turtles with wire only, and 8 (16%) turtles with a combination of plates and screws and wires. Of the 51 turtles, 13 (25%) did not survive > 4 weeks following hardware repair, leaving 38 animals available to assess fracture healing. Median time to start staged removal was 42 days (range, 35 to 49 days) and to complete removal of the applied hardware was 56 days (range, 26 to 77 days). Complications associated with placement of the hardware occurred in 6 of 38 (16%) turtles. Complications included screw hole infection (4/38 [11%]), fracture necrosis (1/38 [3%]), and deep screw hole penetration (1/38 [3%]).

CLINICAL RELEVANCE
Results indicated that shell fractures in freshwater turtles treated with surgical fixation techniques had a successful outcome. Most complications were minor, and fractures improved with time, resulting in acceptable fracture healing for release.
FIGUR NARATIF DALAM SENI PATUNG
Authors: Prasetyo Asep 
Published: January 2022

Tema yang diangkat adalah tentang figur naratif yang divisualisasikan melalui karya seni tiga dimensi. Kecintaan seniman terhadap mainan anak dan pengaruh siaran televisi berdampak pada penciptaan karya.Aktifitas mengumpulkan mainan dan menonton film animasi merupakan suatu kesenangan tersendiri bagi seniman yang secara tidak sadar telah memengaruhi seniman dalam berbuat atau pun membuat karya seni yang dilakukan selama ini. Begitu juga dengan cerita dari sebuah film, juga dijadikan sebagai konsep dalam berkarya.Sebuah cerita naratif juga dijadikan sebagai konsep atas perwujudan karya, seperti halnya dalam komik, penikmat dapat langsung menangkap pesan yang masuk di dalamnya, karena adanya teks yang memperkuat gambar. Dalam pembuatan karya seniman mencoba menghadirkan cerita naratif dalam wujud karya tiga dimensi.Dalam perwujudan karya yang menempatkan cerita sebagai landasan awal dalam membuat bentuk, didapati sebuah realitas baru saat proses pengerjaan karya dengan teknik dan material. Teknik yang dipakai seniman yang mayoritas menggunakan material dari barang temuan menyebabkan cerita tidak dapat diwujudkan secara terperinci dan detail seperti halnya pada komik ataupun pada novel grafis.Kata kunci: figur, naratif, cerita, kumpulan