bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Divergent Selection on Breast Meat Ultimate pH, a Key Factor for Chicken Meat Quality, is Associated With Different Circulating Lipid Profiles
Authors: Beauclercq Stéphane , Mignon-Grasteau Sandrine , Petit Angélique , Berger Quentin , Lefèvre Antoine , Métayer-Coustard Sonia , Tesseraud Sophie , Emond Patrick , Berri Cécile , Le Bihan-Duval Elisabeth 
Published: June 2022

Background: Chicken meat has become a major source of protein for human consumption. However, the quality of the meat is not yet under control, especially since pH values that are too low or too high are often observed. In an attempt to get a better understanding of the genetic and biochemical determinants of the ultimate pH, two genetic lines of broilers were divergently selected for low (pHu−) or high (pHu+) breast meat pHu. In this study, the serum lipidome of 17-day-old broilers from both lines was screened for pHu markers using liquid-chromatography coupled with mass spectrometry (LC-HRMS).Results: A total of 185 lipids belonging to 4 groups (glycerolipids, glycerophospholipids, sterols, sphingolipids) were identified in the sera of 268 broilers from the pHu lines by targeted lipidomics. The glycerolipids, which are involved in energy storage, were in higher concentration in the blood of pHu− birds. The glycerophospholipids (phosphatidylcholines, phosphatidylethanolamines) with long and polyunsaturated acyl chains were more abundant in pHu+ than in pHu− while the lysophosphatidylcholines and lysophosphatidylethanolamines, known to be associated with starch, were observed in higher quantity in the serum of the pHu− line. Finally, the concentration of the sterols and the ceramides, belonging to the sphingolipids class, were higher in the pHu+ and pHu−, respectively. Furthermore, orthogonal partial least-squares analyses highlighted a set of 68 lipids explaining 77% of the differences between the two broilers lines (R2Y = 0.77, Q2 = 0.67). Among these lipids, a subset of 40 predictors of the pHu value was identified with a Root Mean Squared Error of Estimation of 0.18 pH unit (R2Y = 0.69 and Q2 = 0.62). The predictive model of the pHu value was externally validated on 68 birds with a Root Mean Squared Error of Prediction of 0.25 pH unit.Conclusion: The sets of molecules identified will be useful for a better understanding of relationship between serum lipid profile and meat quality, and will contribute to define easily accessible pHu biomarkers on live birds that could be useful in genetic selection.
Characterizing Sleep Differences in Children With and Without Sensory Sensitivities
Authors: Hartman Amy G. , McKendry Sarah , Soehner Adriane , Bodison Stefanie , Akcakaya Murat , DeAlmeida Dilhari , Bendixen Roxanna 
Published: June 2022

ObjectivesIndividuals register and react to daily sensory stimuli differently, which influences participation in occupations. Sleep is a foundational nightly occupation that impacts overall health and development in children. Emerging research suggests that certain sensory processing patterns, specifically sensory sensitivities, may have a negative impact on sleep health in children. In this study, we aimed to (i) characterize sleep in children with and without sensory sensitivities and (ii) examine the relationship between sensory processing patterns (using the Sensory Profile-2) and sleep using validated parent- and child-reported questionnaires. We hypothesized that children with sensory sensitivities will exhibit more difficulties with sleep.MethodsWe recruited 22 children (ages 6–10) with sensory sensitivities (SS) and 33 children without sensory sensitivities (NSS) to complete validated sleep and sensory processing questionnaires: the Children’s Sleep Habits Questionnaire (CSHQ), Sleep Self-Report (SSR), and Sensory Profile-2.ResultsChildren with SS had significantly more sleep behaviors reported by both parents (p &lt; 0.001, g = 1.11) and children (p &lt; 0.001, g = 1.17) compared to children with NSS. Specifically, children with SS had higher frequencies of sleep anxiety (p = 0.004, g = 0.79), bedtime resistance (p = 0.001, g = 0.83), and sleep onset delay (p = 0.003, g = 0.95). Spearman’s ρ correlations indicated significant positive correlations between parent- and child-reported sleep. Children with SS showed a larger association and greater variability between sleep and sensory processing compared to their peers. Significant positive correlations between parent-reported sleep behaviors and sensory sensitive and avoiding patterns were identified for both children with SS and NSS. Child-reported sleep behaviors were most strongly associated with sensitive and avoiding patterns for children with NSS and seeking patterns for children with SS.ConclusionWe present evidence that sleep is impacted for children with SS to a greater extent than children with NSS. We also identified that a child’s sensory processing pattern may be an important contributor to sleep problems in children with and without sensory sensitivities. Sleep concerns should be addressed within routine care for children with sensory sensitivities. Future studies will inform specific sleep intervention targets most salient for children with SS and other sensory processing patterns.
Quality of Life Domains in Breast Cancer Survivors: The Relationship Between Importance and Satisfaction Ratings
Authors: Hinz Andreas , Zenger Markus , Schmalbach Bjarne , Brähler Elmar , Hofmeister Dirk , Petrowski Katja 
Published: June 2022

ObjectivesQuality of life (QoL) has been the focus of increasing interest in oncology. QoL assessment instruments implicitly assume that each QoL domain has the same meaning for each patient. The objective of this study was to analyze the importance of and the satisfaction with QoL domains and to analyze the relationship between the two.MethodsA sample of 308 breast cancer survivors was examined twice with a three-month time interval. The women completed the two QoL questionnaires Questions of Life Satisfaction (FLZ-M), which measures participants' satisfaction with eight QoL domains and the subjective importance of those domains to them, and the EORTC QLQ-C30. A sample of 1,143 women from the general population served as controls.ResultsCompared with the general population sample, the patients were less satisfied with their health and more satisfied with all other QoL domains. The subjective importance of health was lower in the patients' sample (Effect size: d = 0.38). Satisfaction with health and importance of health were slightly positively correlated (r between 0.05 and 0.08). The effect of QoL domain importance on general QoL was small (beta between −0.05 and 0.11), and interaction effects between domain importance and satisfaction on the prediction of global QoL were negligible.ConclusionIn addition to satisfaction with QoL dimensions, the subjective importance of these dimensions is relevant for psychooncological research and treatment. Health is not the only relevant QoL domain in breast cancer survivors, other domains such as finances also deserve health care providers' attention.
Efficacy of Integrated Social Cognitive Remediation vs. Neurocognitive Remediation in Improving Functional Outcome in Schizophrenia: Concept and Design of a Multicenter, Single-Blind RCT (The ISST Study)
Authors: Wölwer Wolfgang , Frommann Nicole , Lowe Agnes , Kamp Daniel , Weide Karolin , Bechdolf Andreas , Brockhaus-Dumke Anke , Hurlemann Rene , Muthesius Ana , Klingberg Stefan , Hellmich Martin , Schmied Sabine , Meyer-Lindenberg Andreas ,   For the ISST study group
Published: June 2022

BackgroundAlthough clinically effective treatment is available for schizophrenia, recovery often is still hampered by persistent poor psychosocial functioning, which in turn is limited by impairments in neurocognition, social cognition, and social behavioral skills. Although cognitive remediation has shown general efficacy in improving cognition and social functioning, effects still need to be improved and replicated in appropriately powered, methodologically rigorous randomized controlled trials (RCTs). Existing evidence indicates that effects can most likely be optimized by combining treatment approaches to simultaneously address both social cognitive and social behavioral processes.ObjectivesTo assess whether Integrated Social Cognitive and Behavioral Skill Therapy (ISST) is more efficacious in improving functional outcome in schizophrenia than the active control treatment Neurocognitive Remediation Therapy (NCRT).MethodsThe present study is a multicenter, prospective, rater-blinded, two-arm RCT being conducted at six academic study sites in Germany. A sample of 180 at least partly remitted patients with schizophrenia are randomly assigned to either ISST or NCRT. ISST is a compensatory, strategy-based program that targets social cognitive processes and social behavioral skills. NCRT comprises mainly drill and practice-oriented neurocognitive training. Both treatments consist of 18 sessions over 6 months, and participants are subsequently followed up for another 6 months. The primary outcome is all-cause discontinuation over the 12-month study period; psychosocial functioning, quality of life, neurocognitive and social cognitive performance, and clinical symptoms are assessed as secondary outcomes at baseline before randomization (V1), at the end of the six-month treatment period (V6), and at the six-month follow-up (V12).DiscussionThis RCT is part of the German Enhancing Schizophrenia Prevention and Recovery through Innovative Treatments (ESPRIT) research network, which aims at using innovative treatments to enhance prevention and recovery in patients with schizophrenia. Because this study is one of the largest and methodologically most rigorous RCTs on the efficacy of cognitive remediation approaches in schizophrenia, it will not only help to identify the optimal treatment options for improving psychosocial functioning and thus recovery in patients but also allow conclusions to be drawn about factors influencing and mediating the effects of cognitive remediation in these patients.Trial RegistrationClinicalTrials.gov NCT 02678858, German Study Register DRKS 00010033
Accelerated Global and Local Brain Aging Differentiate Cognitively Impaired From Cognitively Spared Patients With Schizophrenia
Authors: Haas Shalaila S. , Ge Ruiyang , Sanford Nicole , Modabbernia Amirhossein , Reichenberg Abraham , Whalley Heather C. , Kahn René S. , Frangou Sophia 
Published: June 2022

BackgroundAccelerated aging has been proposed as a mechanism underlying the clinical and cognitive presentation of schizophrenia. The current study extends the field by examining both global and regional patterns of brain aging in schizophrenia, as inferred from brain structural data, and their association with cognitive and psychotic symptoms.MethodsGlobal and local brain-age-gap-estimates (G-brainAGE and L-brainAGE) were computed using a U-Net Model from T1-weighted structural neuroimaging data from 84 patients (aged 16–35 years) with early-stage schizophrenia (illness duration &lt;5 years) and 1,169 healthy individuals (aged 16–37 years). Multidomain cognitive data from the patient sample were submitted to Heterogeneity through Discriminative Analysis (HYDRA) to identify cognitive clusters.ResultsHYDRA classified patients into a cognitively impaired cluster (n = 69) and a cognitively spared cluster (n = 15). Compared to healthy individuals, G-brainAGE was significantly higher in the cognitively impaired cluster (+11.08 years) who also showed widespread elevation in L-brainAGE, with the highest deviance observed in frontal and temporal regions. The cognitively spared cluster showed a moderate increase in G-brainAGE (+8.94 years), and higher L-brainAGE localized in the anterior cingulate cortex. Psychotic symptom severity in both clusters showed a positive but non-significant association with G-brainAGE.DiscussionAccelerated aging in schizophrenia can be detected at the early disease stages and appears more closely associated with cognitive dysfunction rather than clinical symptoms. Future studies replicating our findings in multi-site cohorts with larger numbers of participants are warranted.
The Safety of Propofol Versus Sevoflurane for General Anesthesia in Children: A Meta-Analysis of Randomized Controlled Trials
Authors: Zhao Ying , Qin Feng , Liu Yuhang , Dai Yanping , Cen Xiaobo 
Published: June 2022

BackgroundPropofol and sevoflurane are the most used anesthetics for pediatric surgery. Emergence agitation, postoperative nausea and vomiting and postoperative pain are the primary adverse effect of these general anesthetics. Many clinical studies had compared the safety of propofol and sevoflurane in pediatric surgery, but the results were controversial.ObjectivesTo evaluate the evidence surrounding the safety of propofol versus sevoflurane for general anesthesia in children.MethodsDatabases including PubMed, Embase, Cochrane Library, China National Knowledge Infrastructure, Wanfang Data and Vip Data were searched to collect relevant articles. Trials were strictly selected according to previously defined inclusion and exclusion criteria. RevMan 5.3 software was used for meta-analyses.ResultsTwenty randomized controlled trials recruiting 1,550 children for general anesthesia were included, with overall low-moderate methodological quality. There was evidence that compared with sevoflurane anesthesia, propofol anesthesia significantly decreased the incidence of emergence agitation (OR = 4.99, 95% CI, 3.67–6.80; P &lt; 0.00001), postoperative nausea and vomiting (OR = 1.91, 95% CI, 1.27–2.87; P  =  0.002) and postoperative pain (OR = 1.72, 95% CI, 1.11–2.64; P = 0.01) in children. However, patients who received sevoflurane tended to have shorter times to eye opening (MD = −2.58, 95% CI, −2.97– −2.19; P &lt; 0.00001) and times to extubation (MD = −1.42, 95% CI, −1.81– −1.02; P &lt; 0.00001).ConclusionsThis review reveals that the children who received propofol anesthesia had the lower risks of emergence agitation, postoperative nausea and vomiting and postoperative pain when compared with sevoflurane anesthesia. But the children who received sevoflurane recovered slightly faster than those received propofol. Considering the limitations of the included studies, better methodological quality and large controlled trials are expected to further quantify the safety of propofol and sevoflurane for general anesthesia in children.
Hybrid Models for Solving the Colebrook–White Equation Using Artificial Neural Networks
Authors: Cahyono Muhammad 
Published: June 2022

This study proposes hybrid models to solve the Colebrook–White equation by combining explicit equations available in the literature to solve the Colebrook–White equation with an error function. The hybrid model is in the form of fH=fo−eA. fH is the friction factor value f predicted by the hybrid model, fo is the value of f calculated using several explicit formulas for the Colebrook–White equation, and eA is the error function determined using the neural network procedures. The hybrid equation consists of a series of hyperbolic tangent functions whose number corresponds to the number of neurons in the hidden layer. The simulation results showed that the hybrid models using five hyperbolic tangent functions could produce reasonable predictions of friction factors, with the maximum absolute relative error (MAXRE) around one tenth, or ten times lower than that produced by the corresponding existing formula. The simplified hybrid models are also given using four and three tangent hyperbolic functions. These simplified models still provide accurate results with MAXRE of less than 0.1%.
Metabolome and Transcriptome Profiling Reveal That Four Terpenoid Hormones Dominate the Growth and Development of Sanghuangporus baumii
Authors: Liu Zengcai , Tong Xinyu , Liu Ruipeng , Zou Li 
Published: June 2022

Sanghuangporus baumii is a traditional medicinal fungus that produces pharmacological terpenoids, but natural resources are insufficient for applications, and its growth and development mechanisms are poorly understood. Combining metabolomic and transcriptomic analyses, we found four terpenoid hormones and a central gene, isopentenyl diphosphate isomerase (IDI), involved in growth and development. Additionally, an exogenous hormone test was used to further confirm the importance of the four terpenoid hormones. Finally, hormone content determination and qRT−PCR were performed to explore the growth and development mechanism; we found thatcis-zeatin (CZ) plays a major role in the mycelia stage, trans-zeatin (TZ) and gibberellin A4 (GA4) are important in the primordia stage, GA4 is crucial for the fruiting bodies stage, and abscisic acid (ABA) may be a marker of maturity. The IDI gene was also found to affectterpenoid hormone content by regulating the relative gene transcript levels, thereby controlling morphological changes in S. baumii. Our results revealthe growth and development mechanisms of S. baumii and may promote the breeding and utilisation of high-quality varieties.
الدليل النقلي من السُّنَّة
Authors: الخطاف حسن 
Published: June 2022

لا يخرج الدليل الكلامي والأصولي الـمُرتبِط بالسُّنَّة النبوية استقراءً عن التواتر والآحاد والمشهور، غير أنَّه توجد إشكالية لدى الدارسين في تشكُّل هذه المصطلحات، وفي ضبط دلالاتها.
فجاءت هذه الدراسة مُبيِّنة أنَّ تشكيلها كان في منتصف القرن الثاني الهجري على يد مُتعاصِرينِ هما: واصل بن عطاء مُؤسِّس المدرسة الاعتزالية، وأبو حنيفة مُؤسِّس المدرسة الحنفية. وهذا التشكيل جاء لضبط الحدود الفكرية وأدلتها في الجانب العقدي، وما هو داخل في مفهوم التأسّي بالنبي عليه الصلاة والسلام، وأنواعه في الجانب التكليفي كما بَيَّنه الأصوليون.
وبَيَّنت الدراسة أيضاً عدم الاتِّفاق على ضبط المراد من هذه المصطلحات، وعلى وجود تداخل فيما بينها؛ فالتفريق بينها أقرب إلى الذاتي منه إلى المعياري، وقد بانَ وجود مصطلحات -إبّان التشكُّل- مُختلِفة في التسمية، ومُتَّحِدة في الدلالة، مثل: المشهور مع المعروف والمستفيض، والآحاد مع الشاذ في بعض الأحيان. وقد جاءت هذه الدراسة حصيلة مناهج عِدَّة، أبرزها: المنهج التحليلي، والمنهج النقدي.
Metode Teknologi Fermentasi Pada Limbah Organik Makanan Sebagai Bahan Alternatif Tambahan Dalam Ransum Ayam Broiler
Authors: Dughita Putri Awaliya , Haryono Awalokta Kusuma Andri , Hakim Abdul , Andika Fitroh Bagus , Norma Respati Adib 
Published: June 2022

Penelitian ini bertujuan untuk mengetahui pengaruh metode teknologi fermentasi pada limbah organik makanan sebagai bahan alternatif tambahan dalam ransum ayam broiler. Penelitian dilaksanakan bulan September 2018 di laboratorium fisika dan kimia Universitas Islam Batik Surakarta. Materi penelitian menggunakan limbah makanan rumah makan yang kemudian difermentasi. Hasil analisis proksimat limbah makanan yang difermentasi yaitu BK 88,91%, Abu 8,94%, Protein 22,40%, Lemak 5,96% dan Serat Kasar 19,12%. Berdasarkan hasil analisis proksimat menunjukkan bahwa fermentasi limbah makanan termasuk dalam bahan pakan sumber protein karena memiliki kandungan protein kasar 20% atau lebih, sedangkan fermentasi limbah rumah makan memiliki kandungan protein kasar sebanyak 22,40%. Penambahan fermentasi limbah rumah makan sebesar 15% dalam ransum ayam broiler dapat dilakukan dengan menambahkan bahan pakan lain seperti jagung, bungkil kedelai, dedak halus, tepung ikan, minyak sawit, dan premix.
Kata Kunci: limbah organik, ransum, ayam broiler
Peran Dosen Pembimbing Lapangan dalam Meningkatkan Efektifitas Program Kampus Mengajar
Authors: Fidesrinur Fidesrinur , Shah Abdullah Hakam , Amelia Zahrina 
Published: June 2022

<p><strong>The objective of the research is to study the role of field advisory lecturer (FAL) in encouraging the effectiveness of teaching assistance program (TAP). The research conducted by using descriptive qualitative method with 4 FALs who supervised 36 students throughout TAP batch 1 and batch 2 around Jakarta and Tangerang. The research finding shows that (1) FAL take important roles in TAP to coordinate planning, actuating, reporting with ministry of education, provincial education office, school and university to assure the positive impact for each side, and (2)TAP is one of Ministry of Education, Culture, Research and Technology policies to synergize between school and university to accelerate basic education quality which is need comprehensive policy dealing conversion within curriculum of each department and its program continuity. It suggest that TAP to be socialized each task among parties, considering curriculum each department for credit semester and assuring continuity of the program</strong></p><p><strong>Keywords – </strong><em>Efektivitas, DPL, Program Kampus Mengajar, MBKM </em></p>
Pemberian Serbuk Kulit Kayu Manis Terhadap Kadar Glukosa Darah Lansia Dengan Diabetes Mellitus
Authors: Kurniawati Dewi , Amelia Dona , Rani Dini 
Published: June 2022

Diabetes melitus adalah kelompok penyakit metabolik dikarakteristikan dengan tingginya kadar glukosa didalam darah (hiperglikemia). Cara pencegahan untuk menurunkan kadar glukosa darah adalah melalui pengobatan non farmakologi yang salah satunya dengan pemberian serbuk kulit kayu manis.Tujuan penelitian ini adalah untuk Untuk mengetahui pengaruh penurunan kadar glukosa dalam darah dengan pemberian serbuk kulit kayu manis terhadap penderita DM tipe II pada lansia. Jenis penelitian adalah Quasi eksperimen dengan metode pendekatan one group pre test-post test with control design. Sampel dalam penelitian ini yaitu sebanyak 30 orang responden lansia serta kadar glukosa darah puasa responden > 100 mg/dL, tiap sampel diberikan serbuk kulit kayu manis sebanyak 1 gr selama 7 hari. Kadar glukosa darah diperiksa 2 kali pada kelompok kontrol dan 2 kali pada kelompok intervensi. Penelitian ini menggunakan analisis paired sampel t-test. Hasil penelitian menunjukkan terjadi penurunan kadar glukosa darah puasa penderita DM tipe II yang signifikan pada kelompok inetervensi dengan nilai p=0,001. Dari penelitian ini dapat disimpulkan bahwa penggunaan serbuk kulit kayu manis dapat menurunkan kadar glukosa darah pada lansia dengan diabetes mellitus.
Pengaruh Visual Album Musik Terhadap Strategi Marketing Brand Studi Kasus Album “MITO” DPR Ian
Authors: Florencine Celia Regina , Kurniawan Ferren Valerie , Fortuna Ivania , Setiabudi Miranda 
Published: June 2022

Di zaman yang serba modern, pengaruh strategi marketing sangat penting untuk meningkatkan suatu brand image. Strategi marketing tentu dilakukan dengan berbagai cara dan dalam berbagai media. Salah satunya pengaruh visual dari suatu brand atau produk yang dapat diingat serta dapat meningkatkan brand awareness kepada para audience. Studi ini dilakukan berdasarkan studi kasus dari album musik “MITO” oleh DPR IAN yang memiliki konsep visual yang unik. Studi ini juga bertujuan untuk mengetahui pentingnya pengaruh visual terhadap marketing suatu brand maupun produk. Metode penelitian dari studi ini dilakukan berdasarkan data primer yaitu secara kuantitatif melalui survey yang dibagikan kepada para audience yang sesuai dengan target market di salah satu platform sosial media serta berdasarkan data sekunder yang diperoleh dari beberapa jurnal dan artikel.

Kata kunci : Strategi Marketing, Album Musik, Visual, Brand/Produk, Cover