bluuebunny/crossref_metadata_2025_split huggingface dataset:
Diagnostic performance of 99mTc-HYNIC-PSMA SPECT/CT for biochemically recurrent prostate cancer after radical prostatectomy
Authors: Li Bo , Duan Lili , Shi Jingqi , Han Yunyun , Wei Wei , Cheng Xiaoliang , Cao Yong , Kader Akeban , Ding Degang , Wu Xinyu , Gao Yongju 
Published: December 2022

Objectives99mTc-HYNIC-PSMA is a novel technetium-99m-labeled small-molecule inhibitor of prostate-specific membrane antigen (PSMA) for detection of prostate cancer. The present study investigated the diagnostic yield of 99mTc-HYNIC-PSMA Single photon emission computed tomography (SPECT)/CT in 147 patients with biochemically recurrent prostate cancer after radical prostatectomy.Methods147 patients with biochemical relapse after radical prostatectomy were finally eligible for this retrospective analysis. The median prostate-specific antigen (PSA) level was 8.26 ng/mL (range, 0.22-187.40 ng/mL). Of the 147 patients, 72 patients received androgen deprivation therapy (ADT) at least 6 months before the 99mTc-HYNIC-PSMA SPECT/CT. All patients underwent planar whole-body scans and subsequent SPECT/CT of the thoracic and abdominal regions after intravenous injection of 705 ± 70 MBq of 99mTc-HYNIC-PSMA. Images were evaluated for the presence and location of PSMA-positive lesions, in which SUVmax were also measured. Detection rates were stratified according to PSA levels, ADT and Gleason scores. The relationships between SUVmax and clinical characteristics were analyzed using univariate and multivariable linear regression models for patients with positive findings.ResultsOf the 147 patients, 99mTc-HYNIC-PSMA SPECT/CT revealed at least one positive lesion in 118 patients with a high detection rate (80.3%). The detection rates were 48.6% (17/35), 85.1% (40/47), 92.1% (35/38), and 96.3% (26/27) at PSA levels of greater than 0.2 to 2, greater than 2 to 5, greater than 5 to 10, and greater than 10 ng/mL, respectively. PSMA SPECT/CT indicated local recurrence, lymph node metastases, bone metastases, and visceral metastases in 14 (9.5%), 73 (49.7%), 48 (32.7%) and 3 (2.0%) patients. The detection rates of local recurrence and metastasis increased with increasing PSA levels. The detection rate was higher in patients treated with ADT than those without (90.3% vs. 70.7%; P =0.0029). In patients with Gleason scores ≥8, detection rate was slightly higher than those with ≤7 (81.7% vs. 78.5%), but not statistically significant (P = 0.6265). Multivariable linear regression analysis showed a significant correlation of PSA levels and ADT with SUVmax (P=0.0005 and P=0.0397).Conclusions99mTc-HYNIC-PSMA SPECT/CT offers high detection rates for biochemically recurrent prostate cancer after radical prostatectomy. The detection rate and SUVmax were positively correlated with PSA levels and ADT.
Flos Puerariae-Semen Hoveniae medicinal pair extract ameliorates DSS-induced inflammatory bowel disease through regulating MAPK signaling and modulating gut microbiota composition
Authors: Chen Xiaofan , Zhang Jiahui , Li Rui , Zhang Hua , Sun Yong , Jiang Li , Wang Xiaoya , Xiong Yaokun 
Published: December 2022

Background: Inflammatory bowel disease (IBD) is a global gastrointestinal disease characterized by relapsing and remitting inflammatory conditions. Flos Puerariae (the flower of Pueraria lobata [Willd.] Ohwi and P. thomsonii Benth.) and Hovenia dulcis Thunb. (Rhamnaceae) are traditional Chinese medicines. This medicinal pair has been used to treat various diseases due to its excellent anti-oxidant and anti-inflammatory activity. However, the effects of extracts from these plants on dextran sulfate sodium (DSS)-induced colitis have not been investigated; further study is needed to improve the understanding of their mechanisms of action and potential applications.Methods: The chemical constitution of extracts from Flos Puerariae and Semen Hoveniae (PHE) was analyzed using UPLC-LTQ-Orbitrap-MS/MS. The protective effects of PHE on mice with DSS-induced colitis were evaluated through assessment of body weight loss, disease activity index (DAI) score, colon length shortening, and pathological changes. The levels of inflammatory cytokines were determined by ELISA and RT-qPCR. Biomarkers of oxidative stress (ROS, CAT, SOD, MDA, and T-AOC) were analyzed using biochemical kits. The expression of MAPK proteins was determined by Western blotting analysis. Gut microbiota were analyzed via 16S rRNA sequencing.Results: Chemical composition analysis indicated that PHE contains various bioactive compounds, including puerarin, kakkalide, tectoridin, and genistin. The findings from this study suggest that PHE could effectively modulate histopathological score, inflammatory cell infiltration, and inflammatory factor secretion. Notably, PHE ameliorated oxidative stress by inhibiting activation of the MAPK pathway, leading to decreased inflammatory mediators and restored antioxidant enzyme activity. Furthermore, PHE treatment regulated the composition of the gut microbiota by increasing the abundance of benign bacteria, such as Akkermansia, and reducing the abundance of harmful bacteria, such as Proteobacteria.Conclusion: The findings from this study demonstrate the mechanism underlying the amelioration of DSS-induced intestinal oxidative stress by PHE and its positive impact on the restoration of the composition of gut microbiota.
The impact of digital transformation on corporate total factor productivity
Authors: Li Na , Wang Xiaohong , Wang Zeren , Luan Xiangyu 
Published: December 2022

IntroductionCorporates need to break through the dilemma of system and efficiency with the help of digital transformation in the digital economy era. This paper aims to examine the influence of digital transformation on corporate total factor productivity by investigating whether and how corporate technical cooperation and ESG performance mediate and moderate the relationship between them.MethodsThis study choose Chinese A-share listed manufacturing firms from 2016–2020 as the research sample and use the FGLS regression model to test the proposed hypotheses.ResultsResults show that digital transformation has a positive effect on corporate total factor productivity, and this positive impact is more pronounced when corporates have higher ESG performance. Corporate technical cooperation plays a mediating role between digital transformation and total factor productivity. ESG performance also plays a positive moderating role in the relationship between digital transformation and corporate technical cooperation.DiscussionOur results contribute to the literature on digital transformation and corporate total factor productivity at the micro-corporate level. Further, our findings offer insights to decision-makers and regulatory bodies regarding the current practices of digital transformation and its potential economic impact.
Telehealth Listening Visits for emotionally distressed mothers of hospitalized newborns: Proof-of-concept
Authors: Segre Lisa S. , McCabe Jennifer E. , Chuffo Davila Rebecca , Arndt Stephan 
Published: December 2022

ProblemNewborn admission to the neonatal intensive care unit (NICU) is stressful. Yet in clinical practice, at best, NICU mothers are screened for depression and if indicated, referred to a mental-health specialist. At worst, no action is taken. Listening Visits, an empirically supported nurse-delivered intervention addressing emotional distress, can be conveniently provided by a NICU nurse. Prompted by the need to minimize face-to-face contacts during the pandemic, the primary purpose of this small pilot trial was to assess the feasibility of having nurses provide Listening Visits to NICU mothers over Zoom. Secondarily, we assessed pre-to post-Listening Visits depression symptom scores as a preliminary evaluation of the effectiveness of this type of support.Materials and methodsNine NICU mothers with mildly to moderately severe depression symptoms received up to six Listening Visits sessions from a NICU nurse via Zoom. Participants completed the Inventory Depression and Anxiety Symptoms-General Depression scale (IDAS-GD) at study entry and 4- and 8-weeks post enrollment. They completed the Client Satisfaction Questionnaire (CSQ) at the 8-week assessment.ResultsUsing an intent-to-treat approach, the effect of time from the mixed model analysis of IDAS-GD was statistically significant (F(2,26) = 10.50, p &lt; 0.001), indicating improvement in IDAS-GD scores from baseline to follow-up. The average CSQ score was high (M = 29.0, SD = 3.3), with 75% of participants rating the quality of help they received as “excellent”.DiscussionIn this pilot trial, we learned it is feasible to provide Listening Visits over Zoom, that this mode of delivery is associated with a significant decrease in depression symptom scores, and that women value this approach.Clinical trial registration[https://clinicaltrials.gov/], identifier [#201805961].
Concentric regulatory zones failed to halt surging COVID-19: Brooklyn 2020
Authors: Harris Jeffrey E. 
Published: December 2022

MethodsWe relied on reports of confirmed case incidence and test positivity, along with data on the movements of devices with location-tracking software, to evaluate a novel scheme of three concentric regulatory zones introduced by then New York Governor Cuomo to address an outbreak of COVID-19 in South Brooklyn in the fall of 2020. The regulatory scheme imposed differential controls on access to eating places, schools, houses of worship, large gatherings and other businesses within the three zones, but without restrictions on mobility.ResultsWithin the central red zone, COVID-19 incidence temporarily declined from 131.2 per 100,000 population during the week ending October 3 to 62.5 per 100,000 by the week ending October 31, but then rebounded to 153.6 per 100,000 by the week ending November 28. Within the intermediate orange and peripheral yellow zones combined, incidence steadily rose from 28.8 per 100,000 during the week ending October 3 to 109.9 per 100,000 by the week ending November 28. Data on device visits to pairs of eating establishments straddling the red-orange boundary confirmed compliance with access controls. More general analysis of device movements showed stable patterns of movement between and beyond zones unaffected by the Governor's orders. A geospatial regression model of COVID-19 incidence in relation to device movements across zip code tabulation areas identified a cluster of five high-movement ZCTAs with estimated reproduction number 1.91 (95% confidence interval, 1.27–2.55).DiscussionIn the highly populous area of South Brooklyn, controls on access alone, without restrictions on movement, were inadequate to halt an advancing COVID-19 outbreak.
Análisis geotécnico de la estabilidad del talud “El Álamo”, ubicado en la antigua carretera de Mil Cumbres
Authors: Arreygue Rocha José Eleazar , Ávila Ambriz G.H. , Hurtado Beltrán A. 
Published: December 2022

La carretera de Mil Cumbres se construyó en los años 1940’s para conectar la Ciudad de México con Morelia. Hoy en día, se trata de un camino viejo con poco mantenimiento y conservación, que ha presentado varios problemas de inestabilidad de taludes.
En este trabajo, se hace un análisis geomecánico del talud que se ubica en el tramo km 207+234 (México-Morelia), debido a que se h
La carretera de Mil Cumbres se construyó en los años 1940’s para conectar la Ciudad de México con Morelia. Hoy en día, se trata de un camino viejo con poco mantenimiento y conservación, que ha presentado varios problemas de inestabilidad de taludes.
En este trabajo, se hace un análisis geomecánico del talud que se ubica en el tramo km 207+234 (México-Morelia), debido a que se han presentado diferentes eventos de inestabilidad con caída de bloques de diferentes tamaños a partir del periodo de lluvias ocurrido en el año 2013. El estudio consistió en hacer trabajo de campo, laboratorio, y la aplicación de los métodos de Bieniawski y Romana para caracterizar el material que conforma al talud. Además, se utilizó el software Dips de Rocscience®, para conocer los principales mecanismos de rotura del macizo rocoso y buscar mecanismos para su estabilización.
Con los resultados obtenidos del análisis, se propusieron diferentes estrategias de estabilización con la finalidad de mitigar el desprendimiento de materiales del talud.
an presentado diferentes eventos de inestabilidad con caída de bloques de diferentes tamaños a partir del periodo de lluvias ocurrido en el año 2013. El estudio consistió en hacer trabajo de campo, laboratorio, y la aplicación de los métodos de Bieniawski y Romana para caracterizar el material que conforma al talud. Además, se utilizó el software Dips de Rocscience®, para conocer los principales mecanismos de rotura del macizo rocoso y buscar mecanismos para su estabilización.
Con los resultados obtenidos del análisis, se propusieron diferentes estrategias de estabilización con la finalidad de mitigar el desprendimiento de materiales del talud.
Current injection and luminescence properties of wurtzite InP nanowires with crystal phase transition
Authors: Azuma Yuki , Kimura Shun , Gamo Hironori , Motohisa Junichi , Tomioka Katsuhiro 
Published: December 2022

Abstract
We characterized the current injection and electroluminescence (EL) properties of wurtzite (WZ) InP nanowire (NW) light-emitting diodes (LEDs) with axial junctions. The EL spectra of two samples with the same LED junction structure exhibited two different behaviors. One showed a single EL peak originating from the zinc-blende (ZB)-InP bandgap. The other showed two EL peaks originating from the ZB and WZ phases. This difference in EL behavior is attributed to the difference in the contact position and to depletion layer spreading. Clarification of the origin of the different EL peaks is important for optimizing the NW-LED structure.
Core diameter and numerical aperture dependences on the performance of fiber-optic multimode interference sensing
Authors: Wang Kun , Mizuno Yosuke , Su Xingyu , Dong Xingchen , Kurz Wolfgang , Fink Maximilian , Lee Heeyoung , Jakobi Martin , Koch Alexander W. 
Published: December 2022

Abstract
Modal interference in a multimode fiber (MMF) has been utilized to develop simple sensors for various physical parameters. Herein, first, we investigate the dependences of the core diameter and the numerical aperture (NA) of the MMF on the performance of multimode-interference-based strain and temperature sensing. We find that a larger core diameter leads to higher temperature sensitivity but lower strain sensitivity (absolute value) and that higher NA does not influence the temperature sensitivity but results in higher strain sensitivity (absolute value). Subsequently, using the obtained low strain sensitivity, we demonstrate strain-insensitive temperature sensing with a sensitivity of approximately 6.1 pm °C−1.
DMD-based pure-phase superpixel method for digital holography
Authors: Xie Qian , Yu Song-Tao , Wang Xuan-Kai , Zheng Yong-Guang , Yuan Zhen-Sheng 
Published: December 2022

Abstract
In this work, we implement a pure-phase superpixel (PPSP) method with a digital micromirror device (DMD). Here the DMD acts in an unconventional mode, i.e. as a phase-only modulator with hundreds of phase levels. An iterative Fourier transform algorithm is adapted to the DMD with high quality in a 2f-configuration without filters. When using 1600 × 1600 DMD pixels, the simulations show that the PPSP method in combination with the mixed-region amplitude freedom algorithm reduces the root-mean-square error by at least 33.5% compared with the conventional amplitude and phase modulation methods, and provides higher efficiency by 7.3%.
PENGARUH MEDIA VIDEO PEMBELAJARAN DAN PERAN GURU TERHADAP HASIL BELAJAR MATEMATIKA DENGAN MOTIVASI SEBAGAI VARIABEL INTERVENING ( STUDY KASUS PADA SISWA KELAS VI SD GUGUS 1 KECAMATAN BINUANG )
Authors: Lily Lily Norma Yanti 
Published: December 2022

Berdasarkan informasi data awal yang diperoleh, hasil rekapitulasi nilai rata – rata PTS semester 1 siswa kelas VI di Gugus 1 Kecamatan Binuang pada 3 tahun terakhir mengalami penurunan.Penelitian ini bertujuan untuk mengetahui pengaruh langsung dan pengaruh tidak langsung dari media video pembelajaran, peran guru terhadap hasil belajar matematika dengan motivasi sebagai variabel intervening.Penelitian ini berjenis penelitian ex post facto dengan pendekatan kuantitatif. Populasi dalam penelitian ini adalah seluruh siswa kelas VI SD di Gugus 1 Kecamatan Binuang. Adapun sampel dalam penelitian ini ada 60 orang dengan teknik pengambilan Purposive sampling. Data diuji dengan Smart PLS versi 3.0.Hasil penelitian ini menunjukkan bahwa; 1) media video pembelajaran tidak berpengaruh signifikan terhadap motivasi 2) Peran guru berpengaruh signifikan terhadap motivasi 3) media video pembelajaran berpengaruh signifikan terhadap hasil belajar 4) peran guru tidak berpengaruh signifikan terhadap hasil belajar 5) motivasi berpengaruh signifikan terhadap hasil belajar 6) media video pembelajaran tidak berpengaruh signifikan terhadap hasil belajar matematika dengan motivasi sebagai variabel intervening 7) Peran guru berpengaruh signifikan terhadap hasil belajar matematika dengan motivasi sebagai variabel intervening pada siswa kelas VI SD Gugus 1 Kecamatan Binuang.
PENGARUH RASIO LIKUIDITAS,SOLVABILITAS,DAN AKTIVITAS TERHADAP KINERJA KEUANGAN (PADA PERUSAHAAN SEKTOR HEALTHCARE YANG TERDAFTAR DI BURSA EFEK INDONESIA TAHUN 2018-2020)
Authors: LYSUS HERAWATI PRASTHIWI  
Published: December 2022

ABSTRAK: Hasil analisis rasio dapat menggambarkan kondisi keuangan suatu perusahaan dimana bisa terlihat variasi rasio keuangan pada periode tertentu. Intinya adalah untuk mengevaluasi kelayakan pilihan yang dibuat oleh organisasi dalam beroperasi. maka tujuan penelitian ini sebagai berikut: ; Untuk menganalisis apakah rasio Likuiditas, Solvabilitas dan Aktivitas berpengaruh simultan Dan Secara Parsial terhadap kinerja keuangan pada perusahaan sektor Healthcare yang terdaftar di Bursa Efek Indonesia. Untuk menganalisis manakah diantara rasio Likuiditas, Solvabilitas dan Aktivitas yang berpengaruh dominan terhadap kinerja keuangan pada perusahaan sektor Healthcare yang terdaftar di Bursa Efek Indonesia. Penelitian yang dilakukan adalah penelitian kuantitatif korelasional yang menggunakan metode statistik untuk mengukur pengaruh antara 2 variabel atau lebih ( Cresswell : 2014) Populasi Berdasarkan penelitian ini Perusahaan sektor Healthcare yang terdaftar di Bursa Efek Indonesia. Berdasarkan data per tanggal 15 November 2020, didapatkan data bahwa terdapat 23 perusahaan sektor HeathcareModel Regresi Linier Berganda serta bantuan program SPSS for Windows Versi.20 dengan persyaratan apabila nilai hitung validitas setiap item pernyataan dengan tingkat kepercayaan atau signifikansi lebih kecil dari 0,05 maka pernyataan tersebut dapat dikatakan valid. Rumus linier berganda digunakan untuk menguji pengaruh 3 variabel independent ( Current Ratio , Debt to Equity Ratio, Total Assets Turnover) dan variabel dependen (Return On Investment. Kesimpulan Penelitian ini : Rasio likuiditas, solvabilitas dan aktivitas berpengaruh simultan terhadap kinerja keuangan yang diwakili dengan Return On Investment.Rasio likuiditas, solvabilitas dan aktivitas berpengaruh parsial terhadap kinerja keuangan yang diwakili dengan Return On Investment. Rasio Likuiditas berpengaruh Dominan terhadap kinerja keuangan (Return On Investment) pada perusahaan sektor Healthcare yang tercatat di Bursa Efek Indonesia.

Kata Kunci: Rasio likuiditas, solvabilitas, aktivitas Return On Investment
Multisensed Emotions as Adaptation Controllers in Human-to-Serious NeuroGames Communication
Authors: Dias Sofia , Jelinek Herbert , Hadjileontiadis Leontios 
Published: December 2022

<p>Emotion is a complex combination of experiences of consciousness, bodily sensation and behavior, reflecting personal significance of externally and/or internally triggered changes. As an indispensable part of human communication, emotions could be represented within the digital world as means that could control the human interaction with the digital artifacts. When this is combined with gamification, a more engaging communication for the player is established. In this article, we explore how multisensed emotions of players could be used as adaptation controllers within the emotion-aware serious neurogames (SNGs). We first briefly describe the emotion sensing and recognition landscape, examining the emotion-source sensing and emotion inferring approaches. We then discuss the SNGs design framework and the way human-to-SNG communication is set. Additionally, we describe the way the adaptation of the SNG characteristics can be driven by the inferred emotions, towards the achievement of the desired SNG goals. In addition, we demonstrate the feasibility and design characteristics of such multisensed emotion-aware SNGs, by presenting a related application case, namely EmoSense, and evaluate its acceptance as a technological solution in the field of neurofeedback. Finally, we discuss challenges and opportunities in the field. </p>
Profil Keterampilan Proses Sains Mahasiswa Melalui Praktikum Kimia Organik I
Authors: Huliadi Huliadi 
Published: December 2022

Keterampilan proses sains adalah keterampilan dasar yang diperlukan untuk menemukan, mempelajari, menguji, dan membuktikan konsep ilmiah melalui karya ilmiah di laboratorium alam atau buatan. Tujuan penelitian ini adalah untuk mengidentifikasi keterampilan proses sains mahasiswa program studi pendidikan kimia FSTT UNDIKMA pada praktikum kimia organik I. Penelitian ini merupakan penelitian kualitatif. Instrumen penelitian yang digunakan adalah rubrik penilaian Keterampilan proses sains. Keterampilan proses sains yang diukur dibagi menjadi sembilan indikator. Hasil penelitian menunjukkan nilai rata-rata dari sembilan indikator keterampilan proses sains sebesar 2,1. Skor terendah diperoleh pada keterampilan mendefinisikan variabel secara operasional, mengorganisasikan data penelitian, dan menganalisis data dengan skor masing-masing 1,2, 1,3 dan 1,3. Skor tertinggi diperoleh oleh indikator merancnag percobaan. Berdasarkan temuan peneliti, keterampilan proses ilmiah mahasiswa perlu terus dilatih untuk mewujudkan sumber daya manusia yang unggul di abad 21.

Improving Student Collaboration Skills Using Science-Based Student Worksheets

Science process skills are the basic skills needed to discover, study, test, and prove scientific concepts through scientific work in natural or artificial laboratories. The purpose of this study was to identify the science process skills of students of the chemistry education study program FSTT UNDIKMA in organic chemistry practicum I. This research is a qualitative research. The research instrument used was the rubric for the assessment of science process skills. The measured science process skills are divided into nine indicators. The results showed that the average value of the nine indicators of science process skills was 2.1. The lowest scores were obtained on the skills of defining variables operationally, organizing research data, and analyzing data with scores of 1.2, 1.3 and 1.3, respectively. The highest score was obtained by the experimental design indicator. Based on the research findings, students' scientific process skills need to be continuously trained to create superior human resources in the 21st century