bluuebunny/crossref_metadata_2025_split huggingface dataset:
A randomized placebo-controlled trial of convalescent plasma for adults hospitalized with COVID-19 pneumonia
Authors: Thorlacius-Ussing Louise , Brooks Patrick Terrence , Nielsen Henrik , Jensen Bitten Aagaard , Wiese Lothar , Sækmose Susanne Gjørup , Johnsen Stine , Gybel-Brask Mikkel , Johansen Isik S. , Bruun Mie Topholm , Stærke Nina Breinholdt , Østergaard Lars , Erikstrup Christian , Ostrowski Sisse Rye , Homburg Keld Mikkelsen , Georgsen Jørgen , Mikkelsen Susan , Sandholdt Håkon , Leding Cæcilie , Hovmand Nichlas , Clausen Clara Lundetoft , Tinggaard Michaela , Pedersen Karen Brorup Heje , Iversen Katrine Kjær , Tingsgård Sandra , Israelsen Simone Bastrup , Benfield Thomas 
Published: September 2022

AbstractPassive immunotherapy with convalescent plasma may be the only available agent during the early phases of a pandemic. Here, we report safety and efficacy of high-titer convalescent plasma for COVID-19 pneumonia. Double-blinded randomized multicenter placebo-controlled trial of adult patients hospitalized with COVID-19 pneumonia. The intervention was COVID-19 convalescent plasma and placebo was saline allocated 2:1. The primary outcome was clinical status 14 days after the intervention evaluated on a clinical ordinal scale. The trial was registered at ClinicalTrials.Gov, NCT04345289, 14/04/2020. The CCAP-2 trial was terminated prematurely due to futility. Of 147 patients randomized, we included 144 patients in the modified intention-to-treat population. The ordinal clinical status 14 days post-intervention was comparable between treatment groups (odds ratio (OR) 1.41, 95% confidence interval (CI) 0.72–2.09). Results were consistent when evaluating clinical progression on an individual level 14 days after intervention (OR 1.09; 95% CI 0.46–1.73). No significant differences in length of hospital stay, admission to ICU, frequency of severe adverse events or all-cause mortality during follow-up were found between the intervention and the placebo group. Infusion of convalescent plasma did not influence clinical progression, survival or length of hospitalization in patients with COVID-19 pneumonia.
Mapping cumulative pressures on the grazing lands of northern Fennoscandia
Authors: Stoessel Marianne , Moen Jon , Lindborg Regina 
Published: September 2022

AbstractTraditional grazing areas in Europe have declined substantially over the last century. Specifically, in northern Fennoscandia, the grazing land is disturbed by cumulative land-use pressures. Here we analysed the configuration of the grazing land for reindeer and sheep in northern Fennoscandia in relation to the concurrent land-use pressures from tourism, road and railway networks, forestry, industrial and wind energy facilities, together with predator presence and climate change. Our results show that 85% of the region is affected by at least one land-use pressure and 60% is affected by multiple land-use pressures, co-occurring with predator presence and rising temperatures. As such, a majority of the grazing land is exposed to cumulative pressures in northern Fennoscandia. We stress that, if the expansion of cumulative pressures leads to grazing abandonment of disturbed areas and grazing intensification in other areas, it could irreversibly change northern vegetation and the Fennoscandian mountain landscape.
Risk of thrombocytopenic, haemorrhagic and thromboembolic disorders following COVID-19 vaccination and positive test: a self-controlled case series analysis in Wales
Authors: Torabi Fatemeh , Bedston Stuart , Lowthian Emily , Akbari Ashley , Owen Rhiannon K. , Bradley Declan T. , Agrawal Utkarsh , Collins Peter , Fry Richard , Griffiths Lucy J. , Beggs Jillian , Davies Gareth , Hollinghurst Joe , Lyons Jane , Abbasizanjani Hoda , Cottrell Simon , Perry Malorie , Roberts Richard , Azcoaga-Lorenzo Amaya , Fagbamigbe Adeniyi Francis , Shi Ting , Tsang Ruby S. M. , Robertson Chris , Hobbs F. D. Richard , de Lusignan Simon , McCowan Colin , Gravenor Michael , Simpson Colin R. , Sheikh Aziz , Lyons Ronan A. 
Published: September 2022

AbstractThere is a need for better understanding of the risk of thrombocytopenic, haemorrhagic, thromboembolic disorders following first, second and booster vaccination doses and testing positive for SARS-CoV-2. Self-controlled cases series analysis of 2.1 million linked patient records in Wales between 7th December 2020 and 31st December 2021. Outcomes were the first diagnosis of thrombocytopenic, haemorrhagic and thromboembolic events in primary or secondary care datasets, exposure was defined as 0–28 days post-vaccination or a positive reverse transcription polymerase chain reaction test for SARS-CoV-2. 36,136 individuals experienced either a thrombocytopenic, haemorrhagic or thromboembolic event during the study period. Relative to baseline, our observations show greater risk of outcomes in the periods post-first dose of BNT162b2 for haemorrhagic (IRR 1.47, 95%CI: 1.04–2.08) and idiopathic thrombocytopenic purpura (IRR 2.80, 95%CI: 1.21–6.49) events; post-second dose of ChAdOx1 for arterial thrombosis (IRR 1.14, 95%CI: 1.01–1.29); post-booster greater risk of venous thromboembolic (VTE) (IRR-Moderna 3.62, 95%CI: 0.99–13.17) (IRR-BNT162b2 1.39, 95%CI: 1.04–1.87) and arterial thrombosis (IRR-Moderna 3.14, 95%CI: 1.14–8.64) (IRR-BNT162b2 1.34, 95%CI: 1.15–1.58). Similarly, post SARS-CoV-2 infection the risk was increased for haemorrhagic (IRR 1.49, 95%CI: 1.15–1.92), VTE (IRR 5.63, 95%CI: 4.91, 6.4), arterial thrombosis (IRR 2.46, 95%CI: 2.22–2.71). We found that there was a measurable risk of thrombocytopenic, haemorrhagic, thromboembolic events after COVID-19 vaccination and infection.
Applications of complex picture fuzzy soft power aggregation operators in multi-attribute decision making
Authors: Mahmood Tahir , Ali Zeeshan , Aslam Muhammad 
Published: September 2022

AbstractThe major theme of this analysis is to suggest a new theory in the form of complex picture fuzzy soft (CPFS) information and to initiate their major algebraic laws, score value, and accuracy values. The mathematical form of the CPFS set includes three main functions, called supporting, abstinence, and supporting against terms with a prominent characteristic that the sum of the triplet will lie in the unit interval. Further, in the consideration of the power aggregation operator using generalized t-norm and t-conorm and CPFS information, we diagnosed the mathematical concept of CPFS power averaging (CPFSPA), CPFS weighted power averaging (CPFSWPA), CPFS ordered weighted power averaging (CPFSOWPA), CPFS power geometric (CPFSPG), CPFS weighted power geometric (CPFSWPG), CPFS ordered weighted power geometric (CPFSOWPG). Moreover, the major results and their particular investigation of the invented approaches are also deliberated. Additionally, in the consideration of diagnosed operators using CPFS information, we illustrated a MADM (“multi-attribute decision-making”) tool to find the best option from the family of decisions. Finally, we have shown the supremacy and feasibility of the diagnosed operators with the help of sensitive analysis and geometrical representations.
Forward genetic screening identifies novel roles for N-terminal acetyltransferase C and histone deacetylase in C. elegans development
Authors: Malinow Rose Aria , Zhu Ming , Jin Yishi , Kim Kyung Won 
Published: September 2022

AbstractCoordinating the balance between development and stress responses is critical for organismal survival. However, the cellular signaling controlling this mechanism is not well understood. In Caenorhabditis elegans, it has been hypothesized that a genetic network regulated by NIPI-3/Tibbles may control the balance between animal development and immune response. Using a nipi-3(0) lethality suppressor screen in C. elegans, we reveal a novel role for N-terminal acetyltransferase C complex natc-1/2/3 and histone deacetylase hda-4, in the control of animal development. These signaling proteins act, at least in part, through a PMK-1 p38 MAP kinase pathway (TIR-1–NSY-1–SEK-1–PMK-1), which plays a critical role in the innate immunity against infection. Additionally, using a transcriptional reporter of SEK-1, a signaling molecule within this p38 MAP kinase system that acts directly downstream of C/EBP bZip transcription factor CEBP-1, we find unexpected positive control of sek-1 transcription by SEK-1 along with several other p38 MAP kinase pathway components. Together, these data demonstrate a role for NIPI-3 regulators in animal development, operating, at least in part through a PMK-1 p38 MAPK pathway. Because the C. elegans p38 MAP kinase pathway is well known for its role in cellular stress responses, the novel biological components and mechanisms pertaining to development identified here may also contribute to the balance between stress response and development.
Multi-hazard risk characterization and collaborative control oriented to space in non-coal underground mines
Authors: Wu Menglong , Hu Nanyan , Ye Yicheng , Wang Qihu , Wang Xianhua 
Published: September 2022

AbstractIn order to realize accurate risk assessment and collaborative control of multi-hazard risk in non-coal underground mines, a space-oriented risk characterization and collaborative control model of multi-hazard risk in non-coal underground mines is proposed. Statistical analysis of non-coal underground mine accidents from 2000 to 2022, revealing the characteristics of non-coal underground mine accidents and 5 risk types were identified, including cage fall accident, powered haulage accident, fire accident, mine water inrush accident, and roof fall and rib spalling accident. A multi-hazard risk analysis and assessment framework for non-coal underground mines based on the inherent risk of the system, the vulnerability of the disaster-bearing body and the adaptability of the disaster-bearing area is proposed. The multi-hazard inherent risks in non-coal underground mines are comprehensively identified and evaluated in five aspects, including hazardous equipment and facilities, hazardous materials, hazardous processes, hazardous operations and hazardous places, and the characterization and unified measurement of multi-hazard risk is realized by combining the vulnerability index of disaster-bearing body and the adaptability index of disaster-bearing area. Regional multi-hazard risk aggregation is achieved through the Nemerow pollution index and space-oriented multi-hazard risk is obtained. Constructed a multi-hazard safety risk collaborative control system of source identification, classification and control, process control, continuous improvement, and full participation. Finally, the validity and rationality of the risk characterization model and the risk collaborative control system are verified. The research can both support the formulation of macro policies for non-coal underground mines and provide guidance for the specific spatial layout.
Carcass detection and consumption by facultative scavengers in forest ecosystem highlights the value of their ecosystem services
Authors: Inagaki Akino , Allen Maximilian L. , Maruyama Tetsuya , Yamazaki Koji , Tochigi Kahoko , Naganuma Tomoko , Koike Shinsuke 
Published: September 2022

AbstractScavenging is a common feeding behavior that provides ecosystem services by removing potentially infectious waste from the landscape. The importance of facultative scavenging is often overlooked, but likely becomes especially important in ecosystems without obligate scavengers. Here, we investigated the ecological function of vertebrate facultative scavengers in removing ungulate carcasses from Japanese forests that lack obligate scavengers. We found that mammals detected carcasses first more often than birds, and that raccoon dogs (Nyctereutes procyonoides) were the most frequent scavenger to first detect carcasses. However, we found no evidence of there being species that signal the location of carrion to other species via social cues. Instead, higher temperatures promoted earlier detection of the carcasses by scavengers, likely related to increased olfactory signals. The carcasses were completely consumed on average in 7.0 days, reasonably similar to other systems regardless of habitat, indicating that facultative scavengers are providing ecosystem services. Larger carcasses tended to take longer to deplete, but carcasses were consumed faster in warmer temperatures. Our results indicate that facultative scavengers were capable of consuming carrion and contributing ecosystem services in a forest ecosystem that lacks obligate scavengers.
Mechanistic insight into the role of mevalonate kinase by a natural fatty acid-mediated killing of Leishmania donovani
Authors: Prasad Surendra Rajit , Kumar Prakash , Mandal Saptarshi , Mohan Anu , Chaurasia Radhika , Shrivastava Ashish , Nikhil Pallaprolu , Aishwarya Dande , Ramalingam P. , Gajbhiye Rahul , Singh Shriya , Dasgupta Arunava , Chourasia Mukesh , Ravichandiran V. , Das Prolay , Mandal Debabrata 
Published: September 2022

AbstractWe evaluated the anti-leishmanial efficacy of different saturated medium-chain fatty acids (FAs, C8–C18) where FA containing C8 chain, caprylic acid (CA), was found to be most potent against Leishmania donovani, the causative agent for visceral leishmaniasis (VL). Different analogs of CA with C8 linear chain, but not higher, along with a carboxyl/ester group showed a similar anti-leishmanial effect. Ergosterol depletion was the major cause of CA-mediated cell death. Molecular docking and molecular dynamic simulation studies indicated the enzyme mevalonate kinase (MevK) of the ergosterol biosynthesis pathway as a possible target of CA. Enzyme assays with purified recombinant MevK and CA/CA analogs confirmed the target with a competitive inhibition pattern. Using biochemical and biophysical studies; strong binding interaction between MevK and CA/CA analogs was established. Further, using parasites with overexpressed MevK and proteomics studies of CA-treated parasites the direct role of MevK as the target was validated. We established the mechanism of the antileishmanial effect of CA, a natural product, against VL where toxicity and drug resistance with current chemotherapeutics demand an alternative. This is the first report on the identification of an enzymatic target with kinetic parameters and mechanistic insights against any organism for a natural medium-chain FA.
Evaluation of circulating extracellular vesicles and miRNA in neutered and obese female dogs
Authors: da Silva Nunes Paola Caroline , Mazzarella Rosane , da Silveira Juliano Coelho , Dellova Deise Carla Almeida Leite 
Published: September 2022

AbstractAdipose tissue is a metabolic and endocrine organ, and its adipocytes can synthesize and secrete extracellular vesicles (EVs), thus allowing intercellular communication. EVs are nanoparticles that transport lipids, proteins, metabolites, and nucleic acids (mRNA and microRNAs). MicroRNAs (miRNAs) are small, non-coding RNAs that regulate gene expression. miR-132, miR-26b, and miR-155 are associated with obesity, lipid metabolism and adipogenesis. The aim of this study was to evaluate the enriched EVs fraction containing miRNAs (miR-132, miR-26b, and miR-155) in serum from obese female dogs. Thirty-two neutered females in good general condition were recruited, including 21 obese and 11 healthy controls. The initial evaluation of the females included a general physical examination and laboratory tests. Small EVs (sEVs) were isolated from whole blood by serial centrifugation and ultracentrifugation, and nanoparticle analysis was used to determine the size and concentration of serum sEVs. miRNAs were extracted from sEVs enriched fraction and analyzed by real-time polymerase chain reaction. Obese female dogs with hypertriglyceridemia showed an increase in the sEVs concentration and in the expression of miR-132 and miR-26b in sEVs enriched fraction. No changes were observed in the group of obese female dogs with normal serum biochemical profile and in relation to miR-155 expression. These results suggest that obese female dogs with hypertriglyceridemia may present alterations in sEVs and in the expression of miRNAs related to lipid metabolism and adipogenesis.
Integrated optical frequency comb for 5G NR Xhauls
Authors: Lima Eduardo Saia , Borges Ramon Maia , Andriolli Nicola , Conforti Evandro , Contestabile Giampiero , Sodré Arismar Cerqueira 
Published: September 2022

AbstractWe experimentally demonstrate the use of optical frequency combs (OFCs), generated by a photonic integrated circuit (PIC), in a flexible optical distribution network based on fiber-optics and free-space optics (FSOs) links, aimed at the fifth generation of mobile network (5G) Xhauls. The Indium Phosphide (InP) monolithically integrated OFC is based on cascaded optical modulators and is broadly tunable in terms of operating wavelength and frequency spacing. Particularly, our approach relies on applying the PIC in a centralized radio access network (C-RAN) architecture, with the purpose of optically generating two low-phase noise mm-waves signals for simultaneously enabling a 12.5-km of single-mode fiber (SMF) fronthaul and a 12.5-km SMF midhaul, followed by a 10-m long FSO fronthaul link. Moreover, the demonstrator contemplates two 10-m reach 5G wireless access networks operating in the 26 GHz band, i.e. over the frequency range 2 (FR2) from the 5G NR standard. The proposed integrated OFC-based 5G system performance is in accordance to the 3rd Generation Partnership Project (3GPP) Release 15 requirements, achieving a total wireless throughput of 900 Mbit/s.
A study on moment tensor inversion of acoustic emission response on damaging localization of gas-bearing coal under load
Authors: Niu Yue , Wang Enyuan , Li Zhonghui 
Published: September 2022

AbstractDuring the deformation and fracture process, the acoustic emission (AE) signals can be produced for the of coal, rock and other solid materials, which revealing the damage localization evolution process. The effect of gas adsorption and pressure can change mechanical properties of coal mass and affect its damage development. Based on this, the experimental system for gas-bearing coal loading and AE monitoring was constructed, to analyze AE response characteristics under the joint action of loading stress and gas pressure on coal specimen. Afterwards, the damage localization evolution process of coal mass was studied with the moment tensor inversion method. Results showed that temporal response of AE signals was closely related to the damage degree and loading level of coal specimen, which could reveal its local severe damage and final failure characteristics. The spatial distribution and spread trend of AE fracture events inside coal specimen could be calculated through the moment tensor inversion method. It was basically consistent with the results of crack expansion on the specimen surface. The zones, where fracture events occurred intensively, gathered and spread in a continuous trend, were conductive to forming the macrocrack belt macroscopically. It could be regarded as the hazard zone with dynamic failure occurrence. Moreover, when the coal specimen faced the critical failure, the precursor characteristics of AE response appeared with the shear fracture events dominated markedly. The study results provide a new research idea for revealing the damaging localization evolution process under the coupling effect of stress and gas and lay the application foundation.
The effect of job satisfaction regulating workload on miners’ unsafe state
Authors: Chen Lei , Li Hongxia , Zhao Lin , Tian Fangyuan , Tian Shuicheng , Shao Jiang 
Published: September 2022

AbstractMiners’ unsafe behavior is the main cause of accidents in coal mines, and unsafe state have an important influence on unsafe behavior among miners. To minimize accidents from the source of accident chain, we evaluated the impact of workload on miners’ unsafe state. It is important for coal enterprises to monitor miners’ unsafe state and to prevent unsafe accidents. Workload is divided into two dimensions: work time and work demand. Meanwhile, we introduced job satisfaction as a moderating variable. Through empirical research methods, first-line employees from two coal mines in China were enrolled in the questionnaire survey. Regression analysis was used to verify the impact of workload and its various dimensions, job satisfaction, and miners’ unsafe state. We found that workload, work time and work demand have significant positive effects on miners’ unsafe state. Job satisfaction plays a moderating effect in the relationship between workload and miners’ unsafe state. To some extent, a higher job satisfaction was associated with reduced workload, reduced occurrence of miners’ unsafe state and minimal incidences of unsafe accidents. On this basis, measures were proposed to improve miners’ unsafe state in terms of workload and job satisfaction. This study informs the establishment of effective intervention measures to monitor miners’ unsafe state and is also beneficial to the improvement of coal mine safety.
CTLA-4-Ig internalizes CD80 in fibroblast-like synoviocytes from chronic inflammatory arthritis mouse model
Authors: Miura Yoko , Isogai Shyuntaro , Maeda Shinji , Kanazawa Satoshi 
Published: September 2022

AbstractCD80 interact with CD28 and CTLA-4 on antigen-presenting cells, and function in the co-stimulatory signaling that regulates T cell activity. CTLA-4-Ig is used to treat RA by blocking co-stimulatory signaling. Chronic inflammatory arthritis was induced in D1BC mice using low-dose arthritogenic antigens and treated with CTLA-4-Ig. We performed histopathology of the joints and lymph nodes, serological examination for rheumatoid factors, and flow cytometric analysis of isolated synovial cells, including CD45−FLSs and CD45+synovial macrophages. CTLA-4-Ig treatment ameliorated the chronic inflammatory polyarthritis. There was a decrease in the number of infiltrating lymphoid cells in the joints as well as in the levels of RF-IgG associated with a decrease in the number of B cells in the lymph nodes; more than 15% of CD45−FLSs expressed CD80, and a small number of them expressed PD-L1, indicating the presence of PD-L1/CD80 cis-heterodimers in these cells. CTLA-4-Ig internalized CD80, but not PD-L1, in isolated synovial cells. Gene ontology analysis revealed that CTLA-4-Ig internalization did not significantly alter the expression of inflammation-related genes. The therapeutic effect of CTLA-4-Ig appears to extend beyond the lymph nodes into the inflamed synovial compartment through the synergistic inactivation of T cells by the CD80 and PD-L1 axes.