bluuebunny/crossref_metadata_2025_split huggingface dataset:
Gastroduodenal artery embolization for peptic ulcer hemorrhage refractory to endoscopic intervention: A single-center experience
Authors: Khazi Zain M , Marjara Jasraj , Nance Michael , Ghouri Yezaz , Hammoud Ghassan , Davis Ryan , Bhat Ambarish 
Published: June 2022

Objective
To determine the efficacy of gastroduodenal artery embolization (GDAE) for bleeding peptic ulcers that failed endoscopic intervention. To identify incidence and risk factors for failure of GDAE.

Materials and Methods
A retrospective review of patients who underwent GDAE for hemorrhage from peptic ulcer disease refractory to endoscopic intervention were included in the study. Refractory to endoscopic intervention was defined as persistent hemorrhage following at least two separate endoscopic sessions with two different endoscopic techniques (thermal, injection, or mechanical) or one endoscopic session with the use of two different techniques. Demographics, comorbidities, endoscopic and angiographic findings, significant post-embolization pRBC transfusion, and index GDAE failure were collected. Failure of index GDAE was defined as the need for re-intervention (repeat embolization, endoscopy, or surgery) for rebleeding or mortality within 30 days after GDAE. Multivariate analyzes were performed to identify independent predictors for failure of index GDAE.

Results
There were 70 patients that underwent GDAE after endoscopic intervention for bleeding peptic ulcers with a technical success rate of 100%. Failure of index GDAE rate was 23% (n = 16). Multivariate analysis identified ≥2 comorbidities (odds ratio [OR]: 14.2 [1.68-19.2], P = 0.023), days between endoscopy and GDAE (OR: 1.43 [1.11-2.27], P = 0.028), and extravasation during angiography (OR: 6.71 [1.16-47.4], P = 0.039) as independent predictors of index GDAE failure. Endoscopic Forrest classification was not a significant predictor for the failure of index GDAE (P > 0.1).

Conclusion
The study demonstrates safety and efficacy of GDAE for hemorrhage from PUD that is refractory to endoscopic intervention. Days between endoscopy and GDAE, high comorbidity burden, and extravasation during angiography are associated with increased risk for failure of index GDAE.
Multiple non-contiguous anticoagulation-related spontaneous acute spinal intradural extramedullary hemorrhages
Authors: Brooks Christopher Alan , Mahajan Sameer , Choy Wen Jie , Rajah Jayant , Damodaran Omprakash 
Published: June 2022

Background:
Spinal intradural extramedullary hemorrhage is a rare and important pathology that may precipitate acute compressive myelopathy. It is most commonly associated with spinal trauma, neoplasia, vasculopathy, and iatrogenesis. In rare circumstances, it occurs spontaneously secondary to anticoagulant and antiplatelet medications without an underlying structural lesion. In these instances, it may be related to vasculopathy and/ or cardiovascular disease risk factors. We highlight the salient clinical and radiological features of this pathology, discuss putative mechanisms of its pathogenesis, and describe surgical considerations related to its management.

Case Description:
This report describes an elderly gentleman who presented with two discrete spinal hemorrhages associated with separate foci of bleeding, in the context of therapeutic anticoagulation, on a background of significant structural and functional cardiovascular disease with risk factors.

Conclusion:
Our report is novel in that there are no other cases, to the best of our knowledge, of multiple non-contiguous anticoagulation-related spontaneous acute spinal intradural extramedullary hemorrhages in the medical literature. This article is written with the purpose of assisting clinicians to recognize and expedite treatment of this rare pathology. Prompt diagnosis followed by urgent decompressive surgery provides the best functional outcomes.
The need for an institution-specific normal pressure hydrocephalus management protocol
Authors: Zhu Ning , Sadasivan Ananthababu Pattavilakom 
Published: June 2022

Background:
Despite the publication of international guidelines, the management of normal pressure hydrocephalus (NPH) varies due to clinician preference and varying clinical evidence. An audit was performed to review the current pathways used in clinical practice with the aim of formulating an institution-specific protocol to optimize and standardize care.

Methods:
An internal audit was performed on the management of patients with NPH who presented to the Princess Alexandra Hospital, Brisbane between January 2016 and February 2019.

Results:
Forty-one patients were included in the study. Lumbar puncture (LP) was the main diagnostic test used (63.4%). About 14.6% underwent lumbar drain (LD) insertion instead. About 12.2% did not undergo either LP or LD before definitive treatment. Only 60% of all patients underwent ventriculoperitoneal shunt insertion. Overall, five treatment pathways were noted. LP + VP shunt showed the greatest average improvement in Montreal Cognitive Assessment (MoCA) or Mini-Mental State Examination (MMSE) (+3.8 ± 3.18), followed by LD + VP shunt (+3.25 ± 3.52) and sole treatment with LP (+1.83 ± 1.18). Both pre and post intervention assessment of gait and cognition were only performed in 31% and 48.8% of patients, respectively. Four types of cognitive assessment were used (MOCA 46.4%, MMSE 46.4%, Rowland Universal Dementia Assessment Scale 3.6%, and Addenbrooke’s Cognitive Examination-III 3.6%). MoCA showed greater cognition improvement (2.07) compared to MMSE (1.3) post intervention. There was no consistent objective gait assessment test used.

Conclusion:
The multiple NPH treatment pathways, low rate of pre and post objective symptom assessment, and lack of standardized gait and cognitive assessment tests demonstrate a clear need for an institution-specific NPH management protocol to standardize diagnostic workup, definitive management, and allied health assessment.
Science Teachers’ Practices During the Pandemic in Portugal
Authors: Baptista Mónica , Costa Estela 
Published: June 2022

This paper aims to examine how science teachers adapted their practices to the context of the Covid-19 pandemic and what they learned during the period of confinement.
The participants are fifteen science teachers who currently collaborate on a STEM research project. To collect the data, we used two techniques (individual interviews and teachers’ individual written reflections), which have been analysed using an inductive content analysis approach. The results reveal that adjustments have been made in the design and management of classes. Synchronous classes using digital platforms and other communication infrastructure have been held; experimental distance activities have been implemented, and online courses based on a television programme have been taught. In addition, during the period of confinement, to enable distance learning, teachers developed pedagogical skills using technological skills. Finally, this study highlights the importance of teachers’ role in crisis management, such as during the Covid-19 pandemic.
Struktur Modal, Ukuran Perusahaan, Pertumbuhan Perusahaan dan Tax Avoidance Terhadap Nilai Perusahaan
Authors: Sa'diyah Chalimatus , Hariyono Anwar 
Published: June 2022

This study aims to examine the effect of capital structure, firm size, firm growth and tax avoidance on firm value. The novelty in this study is found in the population used by manufacturing companies listed on Indonesia Stock Exchange (IDX) during the period 2017-2019. Sample determination was done by purposive sampling method, 168 samples selected on this study. This study uses quantitative methods with secondary data sources in the form of complete company annual reports. Methods of data analysis using multiple linear regression analysis. The results showed that partially the firm size and firm growth have a effect on firm value. While the capital structure and tax avoidance have no effect on firm value. Then, simultaneously the capital structure and firm size have a (significant) effect on firm value. Firm growth and tax avoidance have a effect on firm value.
Teknologi Finansial, Literasi Keuangan, dan Keputusan Investasi Produk Reksa Dana di Indonesia
Authors: Kusumahadi Teresia Angelia , Utami Novia 
Published: June 2022

Penelitian dilakukan untuk melihat karakteristik dari pengguna teknologi finansial reksa dana di Indonesia, hubungan antara penggunaan teknologi finansial investasi dan literasi keuangan terhadap keputusan investasi, serta perbedaan literasi keuangan antara investor yang menggunakan teknologi finansial dan investor yang tidak menggunakannya. Dengan menggunakan sampel sebanyak 219 responden yang pernah atau sedang memiliki produk investasi reksa dana, kami menemukan bahwa sebagian besar responden pernah menggunakan teknologi finansial, dengan Bibit dan Bareksa sebagai platform yang paling sering digunakan.
Dengan menggunakan metode OLS, ditemukan bahwa keputusan investasi dipengaruhi secara positif dan signifikan oleh variabel literasi keuangan. Sebaliknya, penggunaan teknologi finansial tidak memiliki pengaruh terhadap keputusan investasi yang dilakukan. Selain itu, investor yang menggunakan layanan teknologi finansial memiliki skor literasi keuangan yang lebih rendah dibandingkan dengan investor yang tidak menggunakan teknologi finansial. Temuan ini menekankan kepada kita perlunya sosialiasi yang lebih merata mengenai teknologi finansial dan literasi keuangan, yang pada akhirnya diharapkan berdampak pada meningkatnya inklusi keuangan.
Bukovyna dialect of the village Yuzhynets
Authors: Koliesnik Liudmyla 
Published: June 2022

The article deals with description of one dialect as a system. The purpose of of this study is to describe the main features of the dialect v. Yuzhynets, manifested in oral dialectal speech, at all language levels. Attention is drawn to typical phonetic, morphological and syntactic dialectal features.
The author’s own records from this dialect (2015) and dictionary materials are the source base of the study. The interview method was used to record the material. We created a relaxed communication situation and encouraged speakers to talk about different topics.
The author applied the method of continuous selection of linguistic facts from transcribed texts, the method of their synthesis, description, comparison and comparison with other dialects and literary language.
It should be emphasized that the speech of villagers of different sexes and ages has all the typical features of speech, but it differs from number and frequency. Naturally, most of these features are in the speech of the oldest villager. Тypical phonetic features: change and alternation of sounds, different nature of sounds compared to literary language. The features of word change of noun parts of speech and conjugation of verbs, morphological features of nouns (vacillation in the genus), adjectives (creation of degrees of comparison), dialectal forms of pronouns, numerals and adverbs are characterizes for the dialect morphological system. The peculiar prepositional-noun constructions in the syntactic structure of dialect speech, active use of dialectal conjunctions and amplifying particles are revealed. The manifestations of ancient original features of the Ukrainian language were observed: consistent use of the vocative form, remnants of the dual form, «honorable» plural, the forms plusquamperfect. Some previously unknown words and phrases have been found, they enriches the vocabulary of the dialect. It is specially noted that men’s speech is exposed to greater, but not critical external influence. The no significant external influences on the dialectal system were noted, despite the relative proximity village to the border regional territories. The obtained results make it possible to resistance of dialectal features to leveling and therefore this dialect is typical Bukovyna dialect. Some previously unrecorded tokens and phrases that supplement the vocabulary of the dialect are recorded.
Keywords: dialect, Bukovyna dialects, typical dialect features, dialect speech, dialect text.
Pengaruh Model Problem Based Learning pada Pembelajaran Fisika Siswa SMA
Authors: Gumay Ovilia Putri utami 
Published: June 2022

Penelitian ini dilatarbelakangi oleh permasalahan yang peneliti peroleh yaitu masih rendahnya hasil belajar fisika siswa karena kurangnya keterlibatan dan kemandirian siswa secara aktif dalam pembelajaran. Masalah dalam penelitian ini adalah Apakah ada pengaruh model Problem Based Learning terhadap pembelajaran fisika siswa SMA?. Tujuan dalam penelitian ini adalah untuk mengetahui pengaruh model Problem Based Learning terhadap pembelajaran fisika siswa SMA. Jenis Penelitian ini adalah penelitian eksperimen sungguhan, desain penelitiannya berbentuk control-group pretest-postest. Populasi penelitian ini yaitu seluruh siswa kelas X SMA Negeri Purwodadi Kabupaten Musi Rawas Tahun Pelajaran 2018/2019 yang berjumlah tiga kelas. Sebagai sampelnya adalah kelas X.1 berjumlah 42 siswa dan siswa kelas X.3 yang berjumlah 36 siswa, Teknik pengumpulan data yang digunakan adalah tes. Data yang diperoleh dianalisis menggunakan uji-t. Berdasarkan hasil analisis uji-t untuk tes akhir pada taraf signifikansi = 0,05 diperoleh thitung > ttabel (thitung = 2,65 > ttabel = 1,67), sehingga dapat disimpulkan bahwa ada pengaruh model Problem Based Learning terhadap pembelajaran Fisika Siswa SMA.
Pengembangan E-Modul Praktikum Fisika Berbasis Inkuiri pada Materi Elastisitas dan Hukum Hooke untuk Siswa SMA/SMK
Authors: Sinensis Arini Rosa , Firdaus Thoha , Sofiah Aninatus , Widayanti Widayanti 
Published: June 2022

Pemanfaatan Teknologi dan Informasi harus dioptimalkan dengan baik dalam pembelajaran salah satunya digunakan untuk mengembangkan bahan ajar. Penelitian bertujuan untuk mengembangkan E-modul praktikum fisika berbasis inkuiri pada materi elastisitas dan hukum hooke. Metode yang digunakan adalah Research and Development (R&D). Prosedur pengembangannya dengan model 4D yang terdiri Define (Pendefinisian), Design (Perancangan), Develop (Pengembangan), dan Disseminate (Penyebaran). Instrumen yang digunakan adalah lembar validasi dan kepraktisan produk yaitu berupa angket. Lokasi uji coba produk E-modul ini adalah di SMK Nurul Huda Sukaraja dengan sampel 20 siswa dari kelas XI Multimedia. Hasil uji kelayakan dari ahli (media dan materi) adalah sangat valid dengan perolehan presentase 83,7%. Hasil penelitian uji kepraktisan e-modul skala kecil diperoleh presentase 95,69%, Hasil uji kepraktisan e-modul skala besar diperoleh presentase 95,38% dengan kriteria sangat praktis. Dengan demikian e-modul praktikum fisika yang dikembangkan layak dan praktis digunakan sebagai sebagai bahan ajar pembelajaran praktikum fisika SMA/SMK.
Identifikasi Kemampuab Berpikir Kreatif Siswa Kelas VIII SMP Mambaul Hisan Ngadiluwih Kediri dalam Pemecahan Masalah Materi Tekanan Zat
Authors: Karomah Siti Afidatul , Kurniawan Husni Cahyadi , Sunarmi Nani 
Published: June 2022

kemampuan berpikir kreatif sangat penting dimiliki oleh siswa dalam proses pembelajaran terutama pelajaran fisika. Kemudian dilakukan penelitian yang bertujuan mengidentifikasi tingkat kemampuan berpikir kreatif Kelas VIII SMP Mambaul Hisan Ngadiluwih Kediri dalam pemecahan masalah materi tekanan zat. Aspek kemampuan berpikir kreatif yang diujikan meliputi kelancaran, keluwesan, keaslian, dan elaborasi. Pengumpulan data melalui tes tulis dan wawancara, dimana data yang diperoleh berupa data kuantitatif kemudian dianalisis secara deskriptif. Hasil penelitian menunjukkan kemampuan berpikir kreatif siswa kemampuan tinggi berada tingkat 3 yakni kreatif mampu memenuhi tiga aspek yang diujikan. Siswa kemampuan sedang berada tingkat 2 yakni cukup kreatif mampu memenuhi dua aspek yang diujikan. Siswa kemampuan rendah ada di tingkat 1 dan tingkat 0, siswa tingkat 1 kurang kreatif hanya memenuhi satu aspek saja dan siswa tingkat 0 belum memenuhi salah satu aspek berpikir kreatif yang diujikan.
Pengembang Instrumen Tes Berbasis Literasi Sains Materi Fluida Statis Kelas XI SMA
Authors: Algiranto Algiranto 
Published: June 2022

Penelitian ini bertujuan untuk (1) Mendeskripsikan karateristik instrumen tes berbasis literasi sains materi fluida statis untuk peserta didik kelas XI SMA. (2) Mendeskripsikan kelayakan instrumen tes berbasis literasi sain materi fluida statis untuk peserta didik kelas XI SMA. (3) Mendeskripsikan hasil respon guru dan peserta didik terhadap tes berbasis literasi sain materi fluida statis untuk peserta didik kelas XI SMA. Jenis penelitian ini adalah Research and Development (R&D). Subjek penelitian adalah siswa kelas XI SMA Negeri 3 Merauke. Teknik pengumpulan data yang digunakan meliputi tes, angket, dan dokumentasi. Instrumen tes yang dikembangkan berbentuk tes uraian berwacana yang mencakup empat kategori literasi sains. Hasil karakteristik instrumen tes berbasis literasi sains adalah, terdapat empat indikator soal dengan jumlah soal tes literasi sains yang dikembangkan sebanyak 20 butir soal uraian dengan 4 kategori utama literai sains yakni: Pengetahuan sains, Penyelidikan hakikat sains, Sains sebagai cara berpikir, Interaksi Sains, Teknologi, dan Masyarakat. Butir soal mempunyai kategori literasi sains serta dikaitkan dengan kehidupan sehari-hari. Butir soal mempunyai tingkat kesulitan dan penskoran yang berbeda. Instrumen tes berbasis literasi sains berfungsi untuk mengukur tingkat pemahaman siswa. Kelayakan instrumen tes yang dikembangkan dinyatakan valid. Reliabilitas instrumen tes berbasis literasi sains yang dikembangkan dalam kategori reliabel.
Loss of Cxcr2 in Myeloid Cells Promotes Tumour Progression and T Cell Infiltration in Invasive Bladder Cancer
Authors: Ismail Nur Faezah Binti , Foth Mona , Yousef Amal Rahil Elgaddafi , Cui Ningxuan , Leach Joshua D.G. , Jamieson Thomas , Karim Saadia A. , Salmond Jonathan M. , Morton Jennifer P. , Iwata Tomoko 
Published: June 2022

BACKGROUND: CXCR2 is a chemokine receptor expressed in myeloid cells, including neutrophils and macrophages. Pharmacological inhibition of CXCR2 has been shown to sensitize tumours to immune checkpoint inhibitor immunotherapies in some cancer types. OBJECTIVE: To investigate the effects of CXCR2 loss in regulation of tumour-infiltrating myeloid cells and their relationship to lymphocytes during bladder tumorigenesis. METHODS: Urothelial pathogenesis and immune contexture was investigated in an OH-BBN model of invasive bladder cancer with Cxcr2 deleted in myeloid cells ( LysMCre Cxcr2 flox/flox). CXCR2 gene alterations and expression in human muscle invasive bladder cancer were analysed in The Cancer Genome Atlas. RESULTS: Urothelial tumour pathogenesis was significantly increased upon Cxcr2 deletion compared to wildtype mice. This was associated with a suppression of myeloid cell infiltration in Cxcr2-deleted bladders shortly after the carcinogen induction. Interestingly, following a transient increase of macrophages at the outset of tumour formation, an increase in T cell infiltration was observed in Cxcr2-deleted tumours. The increased tumour burden in the Cxcr2-deleted bladder was largely independent of T cells and the status of immune suppression. The Cxcr2-deleted mouse model reflected the low CXCR2 mRNA range in human bladder cancer, which showed poor overall survival. CONCLUSIONS: In contrast to previous reports of increased CXCR2 signalling associated with disease progression and poor prognosis, CXCR2 was protective against bladder cancer during tumour initiation. This is likely due to a suppression of acute inflammation. The strategy for sensitizing checkpoint immunotherapy by CXCR2 inhibition in bladder cancer may benefit from an examination of immune suppressive status.
Handbook of Florida Agricultural Laws: Environmental and Conservation Regulations
Authors: Olexa Michael T. , Brock Connor 
Published: June 2022

This revised document is part of the Handbook of Florida Agricultural Laws, which was designed to provide an accurate, current, and authoritative summary of the principal Florida laws that directly or indirectly relate to agriculture. It provides a basic overview of the many rights and responsibilities that farmers and farm land owners have under Florida laws. Many readers may value this handbook because it informs them about these rights and responsibilities, and it provides them with good contacts for more detailed information. However, the reader should be aware that because the laws, administrative rulings, and court decisions on which this handbook is based are subject to constant revision, portions of this handbook could become outdated at any time. Many details of cited laws are also left out due to space limitations.
FE118/FE118: Handbook of Florida Agricultural Laws: Environmental and Conservation Regulations (ufl.edu)
PEMANFAATAN KEKAYAAN BUDAYA DAERAH UNTUK PENGEMBANGAN USAHA UMKM KOTA BANDUNG
Authors: Dora Yenny Maya , Sari Oktora Yogi , Sakti Intan Widuri , Saefudin Nugraha , Budiansyah Yusep 
Published: June 2022

Pandemi covid 19 yang melanda dunia berimbas kepada para UMKM, dimana pendapatan para UMKM menurur tajam. Sehingga banyak UMKM yang mengalami mati suri bahkan ada yang bangkrut. Hal ini diakibatkan karena untuk mencegah penyebaran Virus Covid pemerintah membatasi mobilitas semua warganya. Untuk mengatasi hal ini Para UMKM dituntut untuk lebih dapat meningkatkan daya kreativitas dan inovasi terhadap produk yang mereka tawarkan. Mengingat selama pandemi Covid 19 pdroduk yang paling minati adalah produk-produk yang berkaitan dengan kesehatan, maka kreativitas dan inovasi produk dapat memanfaatkan kekayaan budaya daerah yang ada. Kegiatan Pengabdian kepada Masyarakat ini bertujuan untuk mengajarkan kepada para UMKM untuk memanfaatkan kekayaan budaya daerah sebagai bahan kreativitas dan inovasi serta cara menjalin kemitraan guna membantu pengembangan usaha mereka. Metode yang digunakan pada kegiatan pengabdian Kepada Masyarakat ini menggunakan metode daring melalui Zoom Meeting. Materi disampaikan oleh dua narasumber, yaitu : Narasumber dari Hamzah Batik dan Dosen Manajemen Universitas Widyatama. Hasil dari kegiatan ini para UMKM mengerti cara memanfaatkan kekayaan budaya daerah untuk menghasilkan produk yang kreatif dan inovatif serta cara menjalin kemitraan dengan sesama pelaku UMKM. Implikasinya dari kegiatan ini muncul ide-ide produk kreatif dan inovatif yang bersumber dari kekayaan budaya daerah serta terjalin kemitraan antar beberapa UMKM.
SOSIALISASI DAN PENDAMPINGAN PENANAMAN KOPI TERSERTIFIKASI DI DESA RAWABOGO KECAMATAN CIWIDEY
Authors: Komarasakti Dekrita , Komara Erwan , Panjaitan Biller , Ansori Surya 
Published: June 2022

Pengabdian kepada masyarakat atau yang disingkat PKM, adalah salah satu kegiatan tridharma perguruan tinggi yang bertujuan membantu masyarakat tertentu dalam beberapa aktivitas tanpa mengharapkan imbalan dalam bentuk apapun. Secara umum program ini dirancang oleh berbagai universitas atau institut yang ada di Indonesia, salah satunya adalah Universitas sangga Buana YPKP Bandung Jawa Barat untuk memberikan kontribusi nyata bagi bangsa masyarakat, khususnya dalam mengembangkan dan meningkatkan kesejahteraan. Tujuan PKM kali ini adalah memberikan solusi berdasarkan kajian akademik atas kebutuhan, tantangan, atau persoalan yang dihadapi masyarakat, baik secara langsung maupun tidak langsung dalam mengelola sumber daya alam di Desa Rawa Bogo di Kecamatan Ciwidey di Kabupaten Bandung dalam bentuk sosialisasi dan pendampingan menanam bibit kopi tersertifikasi. Metode yang akan digunakan dalam pencapaian tujuan yaitu dengan pendekatan sosial kewilayahan dan pendampingan membuat administrasi proposal bantuan bibit kopi tersertifikasi, pemetaan wilayah penanaman serta pembentukan kelompok tani melalui diskusi forum kelompok sesuai kebutuhan lapangan.