bluuebunny/crossref_metadata_2025_split huggingface dataset:
Socio-economic impact of COVID-19 pandemic lockdown in Ota, Ogun State, Nigeria
Authors: Akinpelu Olusegun Peter , Owolabi Muhydeen Adedeji , Kilasho Omotunde Musiliudeen 
Published: June 2022

Abstract
The study analysis socio-economic impact of COVID-19 pandemic lockdown as perceived by the residents in different residential zones of Ota, Ogun State, Nigeria, this is aimed at proffering recommendations that guide policy framework. The study adopted survey approach. Data for the study were obtained through questionnaire administration. The study area, Ota, was stratified into three residential zones (Core, transition and sub-urban). Using systematic sampling technique, 229 residents from 2% of residential buildings were sampled in the study area. Data collected were analysed with the use of descriptive and inferential statistics. Results of the study established that majority (63.7%) did not believed in the existence of COVID-19 pandemic, while 63.8% of the residents claimed that COVID-19 pandemic was not severe in the area. Over 60% of the residents affirmed that existence of COVID-19 is a political scam. It was found that 66.8% of the residents confirmed that the lockdown had negative impact on the economy of the area. Residents perceived increased incidence of social vices as a result of COVID-19 pandemic lockdown. The COVID-19 pandemic lockdown index (CPLI) reveals theft incidence (4.41), domestic violence (3.85) and less social gathering (3.98) recorded highest index in core, transition and sub-urban respectively. However, the lockdown has least impact on governments’ palliative to the residents. It can be established that there is a no significant variation in the impact of COVID-19 pandemic lockdown in the three residential zones (p < 0.05). It is therefore, recommended that appropriate machinery for effective monitoring and feedback on governments’ intervention programme should be given needed priority.
HbA1c range determination for diabetes treatment in Google Cloud Compute Engine and SerpAPI
Authors: VALAVANDAN RAMAMURTHY , Mukherjee Surasa , R Vijay 
Published: June 2022

Abstract
In this paper, we have taken a use case in the healthcare domain for the determination of factors for an accurate range of HbA1c in diabetics’ treatment. Google Search Engine Application Program Interface (API), SerpAPI@ is evaluated for the execution of Compute engine in Google cloud. As a service in Infrastructure as a Service (IaaS), the Compute Engine gives the accurate value in HbA1c in the work orchestration in Airflow (astronomer) of Apache and Cloud Composer. We have also developed the application layer for every work stream in python and application output is stored in Google Cloud Storage. The accuracy of diabetic range determination is calculated in python as a measure for the healthcare practitioner to provide the right line of treatment for diabetic patients. A python program is developed to connect to the Google Search with a wrapper of SerpAPI in the Google Cloud Scheduler and create the JSON file schema for parameterization of Search Engine API. The results are shared with customers in the healthcare domain. We have also addressed the challenges of diabetic treatment during long-term Covid-19.
Enhancement of the Mechanical Properties of a Geopolymer Concrete Due to Chemical and Microstructural Interaction of the Binder Material
Authors: Karthikadevi S , Saraswathi.R  
Published: June 2022

Abstract
Many experimentation and researchers were made in the recent decades in concrete and advancement in the field of concrete technology were given a major focus. There are so many alternative materials that were identified and researches were carried out for better understanding. In this study, the binder which is to be cement basically is replaced with a combination of Alccofine-1203(A), Metakaolin (MK), and Ground Granulated Blast-furnace Slag (GGBS) in different ratios to arrive a geopolymer concrete mix. In addition, the study also focuses on the chemical interaction of the replacement material and its microstructure interaction. The liquid binder (l/b) ratios varied between 0.48 to 0.54, and about seven geopolymer concrete mixes were arrived and experimental investigation done for mechanical property. The maximum compressive strength obtained from the mix proportions G50M35A15 at an l/b ratio of 0.50 was taken as a mix design for the Geopolymer mix. The identified combination of Granulated Blast-furnace Slag, Metakaolin, Alccofine-1203 (GMA) is used for further study. The experimental study was conducted by casting specimens for evaluating compressive strength, tensile strength and flexural behaviour. It is found that the experimental results proves that there is a significant hike in the mechanical behaviour of the concrete. The microstructure investigation is done by SEM analysis and energy dispersive X-ray analysis (EDAX). The SEM images also indicated a good interlocking characteristics of the materials which in turn directly impacts the mechanical properties of the concrete.
Screening anlotinib responders via blood-based proteomics in non-small cell lung cancer
Authors: Lu Jun , Zhang Wei , Yu Keke , Zhang Lele , Lou Yuqing , Gu Ping , Nei Wei , Qian Jie , Xu Jun , Wang Huimin , Zhong Hua , Han Baohui 
Published: June 2022

Abstract
Anlotinib has been demonstrated to be effective in advanced non-small cell lung cancer (NSCLC) patients. The response stratification of anlotinib remains unclear. In this study, plasma samples from 28 anlotinib-treated NSCLC patients (discovery cohort: 14 responders and 14 non-responders) were subjected to proteomic analysis, and plasma samples from 35 anlotinib-treated NSCLC patients (validation cohort) were subjected to validation analysis. Liquid chromatography-tandem mass spectrometry analysis was performed on samples with different time points, namely baseline (BL), best response (BR), and progression disease (PD). Bioinformatics analysis was performed to screen for the underlying differential proteins. Enzyme-linked immunosorbent assay was performed to detect plasma ARHGDIB, FN1, CDH1, and KNG1 levels respectively. The Kaplan-Meier survival analysis was used for biomarker-based responsive stratification. Our results indicated that differential proteins between responders and non-responders showed that proteomic technology potentially contributes to biomarker screening in plasma samples at BL. Furthermore, our results suggested that the detection of plasma ARHGDIB, FN1, CDH1, and KNG1 levels have potential predictive value for anlotinib response both in discovery cohort and validation cohort. Collectively, this study offers novel insights into the value of plasma biomarker screening via proteomic examination and suggests that plasma ARHGDIB, FN1, CDH1, and KNG1 levels could be used as biomarkers for anlotinib stratification in NSCLC patients.
Esophageal carcinosarcoma comprising of undifferentiated pleomorphic sarcoma and squamous cell carcinoma: A case report
Authors: Fang Ziyao , Pan Shu , Xu Chun , Ju Sheng , Shen Ziqing , Zhao Jun 
Published: June 2022

Abstract
Introduction:
Esophageal carcinosarcoma (ECS) is a rare malignant tumor that often presents as an intraluminal polypoid lesion in the esophageal lumen. Herein we present a case diagnosed as esophageal carcinosarcoma and treated with esophagectomy.
Case presentation:
A 68-year-old male patient was presented to the thoracic surgery department complaining of dysphagia for about three months. He was diagnosed with ECS and underwent uniport video-assisted thoracic surgery (VATS). Based on the histopathological reports, the patient was finally diagnosed as ECS, clinical T1bN0M0, pathological stage I. 11 days after the surgery, the patient was discharged from the hospital without experiencing any complications.
Conclusion
Carcinosarcoma was first described by Virchow in 1865 as a rare malignant neoplasm. The clinical manifestations of ECS includes dysphagia, chest pain and weight loss. IHC analysis indicates carcinoma and the sarcoma occurred independently. Complete resection of the esophagus with lymphadenectomy of locoregional nodes is still recommended as the best potentially curative treatment. For the prognosis of ECS compared to (ESCC), there is a controversy. Here, we reported a case of ECS comprising of squamous cell carcinoma in situ and undifferentiated pleomorphic sarcoma underwent uniport VATS esophagectomy with no serious complications, which indicate that VATS esophagectomy could be applied to ECS patients.
Exploration of inflammation-prognosis correlation and potential regulatory molecules in adamantinomatous craniopharyngioma
Authors: Jia Yibin , Wang Guanyi , Ye Yuqin , Kang Enming , Wu JunFeng , He Xiaosheng , Wang Jiayou 
Published: June 2022

Abstract
Purpose
To explore the inflammation-prognosis correlation and potential regulatory molecules in adamantinomatous craniopharyngioma (ACP)
Methods
61 ACP patients who received surgery by either sub-resection or total-resection were included. Kaplan-Meier Curves were drafted to clarify patients’ prognosis in different sub-groups. Kinds of histological staining were used to evaluate the infiltration and activation of inflammatory cells. The expression dataset of GSE94349 was downloaded from Gene Expression Omnibus (GEO) database for series of bioinformatic analysis. Online bioinformatic analysis databases (Oncomine, GEPIA, TIMER, and NetworkAnalyst, et al) were used for a pan-cancer analysis on potential molecules. Finally, fluorescence in situ hybridization (FISH) and western bolt were conducted to verify the connection between target biomarkers and macrophages.
Results
The extent of resection was irrelevant to the progress free survival (PFS) of the ACP patients. Patients with high grade of inflammation showed worse prognosis than those with low and medium grade. More inflammatory cells infiltrated in recurrent tumor but represented with an immune inhibitory phenotype. Fraction of immune cells was calculated, and ACP was loaded with more M0 macrophages and plasma cells. SERPINs were identified and then a pan-cancer analysis was conducted to verify its value in clinic. At last, single cell sequencing database and FISH results reveals SERPINs mainly expressed in macrophages and monocytes.
Conclusion
Our study reveals a connection between inflammation response and poor prognosis in ACP patients. And SERPINs, especially SERPINE1 might be key inflammatory gene, which is relevant to macrophages.
PENGARUH KOMITE AUDIT, CASH HOLDING, DAN UKURAN PERUSAHAAN TERHADAP PERATAAN LABA
Authors: Choerunnisa Erika 
Published: June 2022

Perataan laba yaitu praktik yang dilakukan oleh manajemen suatu perusahaan yang memiliki tujuan untuk mengurangi fluktuasi laba supaya laba terlihat lebih baik dimata para investor. Perataan dilakukan dengan cara meningkatkan atau menurunkan laba yang akan dilaporkan dengan memindahkan pendapatan tahun yang lebih menguntungkan ke tahun yang kurang menguntungkan. Perataan laba dihitung menggunakan Indeks Eckel (1981), indeks tersebut dapat membedakan perusahaan-perusahaan yang melakukan perataan laba dan yang tidak melakukan perataan laba. Indeks Eckel dihitung dengan cara membandingkan koefisien variasi perubahan laba bersih dengan koefisien variasi perubahan penjualan dalam satu periode. Jika mendapatkan hasil kurang dari 1 maka perusahaan tersebut digolongkan sebagai perata dan termasuk ke dalam kategori 1, sedangkan jika perusahaan tersebut mendapatkan hasil yang lebih dari 1 digolongkan bukan perata laba yang termasuk ke dalam kategori.Penelitian ini bertujuan untuk mengetahui pengaruh secara simultan dan parsial antara komite audit, cash holding, dan ukuran perusahaan terhadap perataan laba pada perusahaan yang termasuk dalam Indeks LQ45 tahun 2014-2018. Hipotesis dalam penelitian ini diuji menggunakan analisis statistik deskriptif dan analisis regresi logistik dengan menggunakan SPSS 26. Populasi dalam penelitian ini adalah perusahaan-perusahaan yang terdaftar dalam Indeks LQ45 tahun 2014-2018. Metode yang digunakan untuk pengambilan sampel adalah purposive sampling yang menghasilkan 22 sampel perusahaan terpilih dalam kurun waktu 5 tahun sehingga diperoleh total sampel pada penelitian ini sebanyak 110 sampel. Berdasarkan hasil penelitian, variabel komite audit, cash holding, dan ukuran perusahaan secara simultan berpengaruh signifikan terhadap perataan laba. Secara parsial, variabel komite audit berpengaruh negatif terhadap perataan laba. Sedangkan variabel cash holding dan variabel ukuran perusahaan tidak berpengaruh secara positif terhadap perataan laba.Kata Kunci: Perataan Laba, Komite Audit, Cash Holding, Ukuran Perusahaan
PENGARUH BLENDED LEARNING TERHADAP AKTIVITAS BELAJAR DAN HASIL BELAJAR MAHASISWA AKUNTANSI
Authors: Fadhilatunisa Della , Fakhri M Miftach , Rosidah Rosidah 
Published: June 2022

Pendidikan tinggi pada abad 21 menuntut dosen dan mahasiswa untuk bersama-sama membentuk lingkungan belajar student centered learning. Penelitian ini bermaksud untuk mengetahui: (1) perspektif mahasiswa terhadap model blended learning, (2) pengaruh model blended learning terhadap aktivitas belajar dan hasil belajar (3) perbedaan hasil belajar mahasiswa kelompok eksperimen dengan kelompok kontrol. Penelitian ini adalah penelitian kuantitatif dengan jenis penelitian eksperimen. Adapun desain penelitian yang digunakan adalah quasi experimental. Populasi penelitian ini adalah mahasiswa semester 1 jurusan akuntansi. Teknik pengambilan sampel menggunakan purposive sampling sehingga sampel penelitian adalah kelas A sebanyak sebanyak 47 orang sebagai kelas eksperimen dan kelas C sebanyak 45 orang sebagai kelas kontrol. Analisis yang digunakan pada penelitian ini yaitu analisis deskriptif dan analisis inferential yaitu paired sample t test dan independent sample t test. Hasil penelitian menunjukkan bahwa: (1) perspektif mahasiswa terhadap model blended learning berada pada kategori baik (2) terdapat pengaruh blended learning terhadap hasil belajar dengan nilai sig kurang dari 0.05, sedangkan mean aktivitas kelompok eksperimen lebih baik dibandingkan kelompok kontrol, dan (3) terdapat perbedaan hasil belajar mahasiswa kelompok eksperimen dengan kelompok kontrol.
KECURANGAN PEMBELAJARAN DARING PADA AWAL PANDEMI: DIMENSI FRAUD PENTAGON
Authors: Christiana Angela , Kristiani Alvina , Pangestu Stevanus 
Published: June 2022

Penelitian ini bertujuan untuk mengetahui pengaruh determinan kecurangan pembelajaran daring selama pandemi COVID-19 menggunakan dimensi fraud pentagon. Variabel independen dalam penelitian ini yaitu, tekanan, peluang, rasionalisasi, kemampuan, dan arogansi. Penelitian ini menggunakan data primer yang diperoleh dengan teknik survei daring dan instrumen kuesioner. Proses analisis dan pengolahan data penelitian dilakukan dengan analisis regresi berganda pada perangkat lunak IBM SPSS Statistics versi 25 dengan jumlah sampel sebanyak 387 mahasiswa akuntansi. Hasil pengujian yang telah dilakukan menunjukkan bahwa variabel tekanan, rasionalisasi, dan kemampuan berpengaruh signifikan terhadap perilaku kecurangan pembelajaran daring. Sedangkan variabel peluang dan arogansi tidak berpengaruh signifikan terhadap perilaku kecurangan pembelajaran daring
PENGARUH KOMPETENSI KEJURUAN AKUNTANSI DAN KEMATANGAN VOKASIONAL TERHADAP KESIAPAN KERJA MELALUI INTERVENING SELF-EFFICACY
Authors: Sholihah Nur Halizatus , Listiadi Agung 
Published: June 2022

Tujuan utama sekolah menengah kejuruan yaitu menciptakan sumber daya manusia yang siap bekerja sesuai bidang keahliannya, namun berdasarkan observasi awal diketahui bahwa masih kurangnya kesiapan kerja siswa yang terlihat pada data jumlah keterserapan kerja tamatan SMKN 2 Buduran program keahlian akuntansi tiga tahun terakhir (2017-2019) yang mengalami penurunan setiap tahunnya. Penelitian kuantitatif ini bertujuan menganalisis pengaruh kompetensi kejuruan akuntansi dan kematangan vokasional secara langsung maupun tidak langsung melalui intervening self-efficacy terhadap kesiapan kerja. Populasi dalam penelitian ini adalah seluruh siswa kelas XII program keahlian akuntansi SMKN 2 Buduran tahun pelajaran 2020/2021 yang berjumlah 107 siswa. Sampel diambil menggunakan teknik sampel jenuh. Data dikumpulkan dengan teknik dokumentasi dan kuesioner yang sudah teruji validitas serta reliabilitasnya. Selanjutnya data dianalisis menggunakan metode analisis deskriptif, analisis regresi linier sederhana, dan analisis jalur. Diperoleh hasil penelitian bahwa kompetensi kejuruan akuntansi tidak berpengaruh pada kesiapan kerja, namun berpengaruh tidak langsung melalui intervening self-efficacy. Kompetensi kejuruan akuntansi dan kematangan vokasional berpengaruh pada self-efficacy. Kematangan vokasional dan self-efficacy berpengaruh pada kesiapan kerja, serta self-efficacy dapat memediasi pengaruh kematangan vokasional terhadap kesiapan kerja.
PENGARUH PERHATIAN ORANG TUA TERHADAP KEBIASAAN BELAJAR SISWA KELAS X JURUSAN AKUNTANSI SMK NEGERI 2 BALIGE
Authors: Sibarani Blasius Erik 
Published: June 2022

Permasalahan dalam penelitian ini adalah rendahnya kebiasaan belajar pada siswa kelas X Jurusan akunatansi SMK Negeri 2 Balige dikarenakan rendahnya perhatian orang tua. Tujuan penelitian ini adalah untuk mengetahui pengaruh perhatian orang tua terhadap kebiasaan belajar siswa kelas X Jurusan Akuntansi SMK Negeri 2 Balige. Penelitian ini dilaksanakan di SMK Negeri 2 Balige. Populasi dalam penelitian ini adalah seluruh siswa kelas X Jurusan Akuntansi SMK Negeri 2 Balige yang berjumlah 107 siswa. Teknik pengambilan sampel yaitu dengan Simpel Random Sampling. Jumlah sampel yang digunakan yaitu sebanyak 100 responden. Data yang diperoleh dianalisis dengan menggunakan teknik analisis PLS (Partial Least Square) melalui software SmartPLS. Teknik pengumpulan data dalam penelitian ini berupa kuesioner. Data yang diperoleh dianalisis dengan menggunakan uji PLS Algoritma, PLS Bootstrapping dan pengujian hipotesis dengan menggunakan Uji-t. Hasil analisis yang diperoleh rata-rata varians direfleksikan diatas 0,5 dan indikator outer loading lebih tinggi dari 0,6. Data dari perhitungan untuk hipotesis perhatian orang tua berpengaruh terhadap kebiasaan belajar siswa diperoleh nilai p-value sebesar 0,002 sedangkan taraf nyata atau α sebesar 0,05 yang berarti hipotesis diterima sehingga dapat disimpulkan bahwa perhatian otang tua berpengaruh terhadap kebiasaan belajar siswa. Kata Kunci: Kebiasaan Belajar, Partial Least Square (PLS), Perhatian Orang Tua
IMPLEMENTASI APLIKASI QUIZIZZ UNTUK KEAKTIFAN PESERTA DIDIK KELAS DARING PADA MATA PELAJARAN AKUNTANSI KEUANGAN
Authors: Astuti Rohana Intan , Utomo Supri Wahyudi , Yusdita Elana Era 
Published: June 2022

Tujuan dalam penelitian ini adalah keaktifan peserta didik didalam kelas pada mata pelajaran akuntansi keuangan dengan menggunakan aplikasi Quizizz untuk melengkapi pembelajaran daring dengan media Whatsapp Grup dan Google Classroom agar materi pelajaran akuntansi keuangan dapat dipahami dengan mudah oleh peserta didik. Metode yang digunakan dalam penelitian ini menggunakan metode kualitatif deskriptif. Informan menggunakan 11 orang yang terdiri dari 1 guru akuntansi keuangan dan 10 peserta didik kelas XI AKL 2 di SMK PGRI Wonoasri. Hasil penelitian menggunakan aplikasi Quizizz ini sangat membantu untuk pembelajaran daring, meningkatkan belajar dan pemahaman peserta didik. Aplikasi Quizizz lebih mudah diakses dan digunakan dari pada aplikasi yang pernah peserta didik gunakan yaitu Google Classroom. Namun aplikasi Quizizz memiliki keterbatasan apabila sinyal tidak stabil saat mengerjakan soal bisa keluar dari aplikasi, meskipun dapat melanjukan soal namun cukup menghambat pengerjaan. Aplikasi Quizizz ini cukup menyenangkan, seru bagi peserta didik yang dapat beradaptasi dengan pembelajaran daring, sedangkan bagi peserta didik yang memiliki gaya belajar auditori yang harus mendengar penjelasan materi secara langsung dari guru saat pembelajaran di kelas, aplikasi Quizizz tidak berhasil menumbuhkan semangat belajarnya.
RETINOL-BINDING PROTEIN 4 IN PATIENTS WITH DIABETES MELLITUS TYPE 2: RELATIONSHIP WITH THE LATEST BIOMARKERS / FACTORS CARDIOVASCULAR RISK
Authors: Gorshunska Maryana 
Published: June 2022

61 patients with type 2 diabetes mellitus were examined (disease duration 6.29 ± 0.67 years)
overweight or obese, middle-aged, with hormonal and metabolic manifestations of insulin resistance (fasting hyperinsulinemia, elevated HOMA-IR indices and
levels of free fatty acids, hypoadiponectinemia, hypertriglyceridemia). Significant increase in circulating levels of retinol-binding protein 4 (RVP4) was verified.
with HOMA-IR indices, osteoprotegerin, progranulin, matrix metalloproteinase 9.
The influence of sex on the severity of RVP4 increase and the associated pattern of macro- / microangiopathies were determined. The prospects of using circulating levels РВР4 as a quality are substantiated
a new biomarker of cardiovascular risk.
PREDICTORS OF MYOCARDIAL REMODELING IN PATIENTS WITH ACROMEGALIA
Authors: Khizhnyak Oksana , Mikityuk Myroslava , Sulima T. N. 
Published: June 2022

The role of a number of clinical and laboratory indicators as possible predictors is analyzed
type of myocardial remodeling in patients with acromegaly. Specific anamnesis data were revealed,
levels of somatotropin, insulin-like growth factor-1, prolactin in the blood, as well as melatonin excretion, which promote the development of different types of myocardial remodeling. Results
are presented in the form of prognostic estimates, the use of which makes it possible to improve early
diagnosis of acromegaloid cardiomyopathy and prognosis for the patient by using modern
pharmacological correction.
Epidemiological analysis of arboviruses in the Triângulo Mineiro from 2014 to 2018
Authors: Gomes Pires João Vítor , Nakajima Noah Romero , Hattori Wallisen Tadashi , De Oliveira Stefan Vilges 
Published: June 2022

Objective: To study the pattern of presentation of arbovirus cases in the Triângulo Mineiro region, Minas Gerais, Brazil. Methods: Cross-sectional, descriptive study with quantitative analysis of data obtained from the Information System of Notifications of Diseases of the Ministry of Health from 2014 to 2018. Results: 106,040 cases of Dengue, 1,691 of Zika, and 421 of Chikungunya were reported. The year with the most Dengue and Zika notifications was 2016; Chikungunya was in 2017. The municipalities with the highest incidence were Água Comprida, Gurinhatã and Araporã, while the lowest were Cascalho Rico, Indianópolis and Cachoeira Dourada. There were more reports from adult females. Conclusion: In the studied region, there was the simultaneous circulation of the three investigated arboviruses, especially Dengue, similar to other Brazilian regions. This study can contribute to planning public policies for the prevention and control of arboviruses.
Kaznodziejstwo. Tom 1: Kościół powszechny
Authors: Panuś Kazimierz 
Published: June 2022

The first volume of the scholarly monograph titled Preaching presents a synthetic panorama of Christian preaching from the time of the apostles to the pontificate of Pope Francis. This volume presents great masters of the pulpit along with their times and exceptional sermons, which enraptured audiences with the beauty of the Gospel of Jesus Christ and led people to salvation. After presenting evangelization in the time of the apostles, forms of preaching and their great representatives in the Middle Ages, modern period, and present day are introduced. This publication also contains the texts of sermons and homilies or important pronouncements about preaching characteristic of a certain time or preacher because sermons were always an important part of cultural life, while many of them have become the literary relics of numerous nations.