bluuebunny/crossref_metadata_2025_split huggingface dataset:
Scrutinizing the role of Genetically Modified Herbs (GMHs) in the Treatment of Various Diseases
Authors: Sindhu Rakesh K. , Verma Rishu , Salgotra Twinkle , Madaan Piyush , Chandel Parteek , Batiha Gaber El-Saber , Cavalu Simona 
Published: May 2022

Background:
Medicinal plants are being manipulated by the variety of methods with genes. Genetic engineering is the alteration of genetic material of an organism via biotechnology techniques. Wide range of genetically modified medicinal plants are diligently examined possessing therapeutic efficacy for the treatment of various diseases, like diabetes, cardiovascular diseases, rheumatoid arthritis, and cancer.

Objective:
This review discloses the numerous genetically modified herbs employed in the treatment of diseases, such as diabetes, cardiovascular diseases, rheumatoid arthritis, and cancer. In addition, the review highlights the therapeutically active constituents present in these herbs, which are liable for their specific pharmacological action.

Methods:
Several review, research papers, and patents highlighting the enormous aptitude of genetically modified herbs in the treatment of various diseases were collected from medical databases, and are exhaustively studied for writing this review paper.

Results:
Due to rapid advancement in the phytochemical investigation of therapeutically active plants, and because of their potential to treat these disorders, they are being rapidly promoted and favoured nowadays. Moreover, a range of active constituents can be isolated from natural plants that can be employed in the treatment of various disorders, and due to their less toxicity they are preferred over synthetic products.

Conclusion:
Utilizing genetically modified herbs, like Azadirachta indica, Allium cepa, Acacia arabica, Allium sativum, and herbal formulations like flaxseed oil, green tea, and many more appear to be a pioneerstrategy in the therapy of these diseases, but still further investigation is required to overcome the negative outcomes of these herbs.
Review on Stenotrophomonas maltophilia: An Emerging Multidrug-
resistant Opportunistic Pathogen
Authors: Majumdar Rikhia , Karthikeyan Hariharan , Senthilnathan Vaishnavi , Sugumar Shobana 
Published: May 2022

:
Stenotrophomonas maltophilia is an opportunistic pathogen that results in nosocomial
infections in immunocompromised individuals. These bacteria colonize on the surface
of medical devices and therapeutic equipment like urinary catheters, endoscopes, and
ventilators, causing respiratory and urinary tract infections. The low outer membrane permeability
of multidrug-resistance efflux systems and the two chromosomally encoded β-
lactamases present in S. maltophilia are challenging for arsenal control. The cell-associated
and extracellular virulence factors in S. maltophilia are involved in colonization and biofilm
formation on the host surfaces. The spread of antibiotic-resistant genes in the pathogenic
S. maltophilia attributes to bacterial resistance against a wide range of antibiotics, including
penicillin, quinolones, and carbapenems. So far, tetracycline derivatives, fluoroquinolones,
and trimethoprim-sulfamethoxazole (TMP-SMX) are considered promising antibiotics
against S. maltophilia. Due to the adaptive nature of the intrinsically resistant
mechanism towards the number of antibiotics and its ability to acquire new resistance via
mutation and horizontal gene transfer, it is quite tricky for medicinal contribution against S.
maltophilia. The current review summarizes the literary data on pathogenicity, quorum
sensing, biofilm formation, virulence factors, and antibiotic resistance of S. maltophilia.
Effect of Solvents on 1-Butyl-1,2,4-Triazolium Trifluoroacetate Triggered
Synthesis of 2,3-Dihydroquinazolin
Authors: Kandasamy Elango , Satheesh Anjitha , Gokuldas Gopika , Gayathri Krishnan M. 
Published: May 2022

Background:
Quinazolinones are a class of heterocyclic compounds that have a wide variety of applications. They are also used in agrochemicals. There are several methodologies reported for the synthesis of 2,3-dihydroquinazolines using various catalysts.

Method:
Here, by using 1-butyl-1,2,4-triazolium as cation and trifluoroacetate as anion, 2,3-dihydroquinazolin-4(1H)-one has been synthesized. For the synthesis of 2,3-dihydroquinazolin-4(1H)-one condensation of anthranilamide with the corresponding aldehyde in the presence of organocatalyst and solvent is done. Using benzaldehyde as the parent aldehyde, to validate the outcome, the benzaldehydes were selected as follows a) benzaldehyde, b) 4-methoxybenzaldehyde – electron releasing group and c) 4-nitrobenzaldehyde – electronwithdrawing group. Solvent study has been done with solvents varied from polar to apolar. Both polar protic and polar aprotic solvents are used for the reactions. The polar protic solvents used were water, methanol, ethanol, isopropanol, butanol, hexane-1-ol, and glycerol. The polar aprotic solvents used are ethyl acetate, DMF,acetonitrile, and DMSO. The moderately apolar solvents used are DCM, carbon tetrachloride, 1,4 dioxane, and chloroform.

Results:
The synthesized triazolium salts are found soluble in polar aprotic, polar protic solvents and few moderately apolar solvents such as DCM, chloroform, acetonitrile, water, methanol and ethanol whereas insoluble with apolar solvents like toluene, benzene, and hexane.The yield of 2-phenyl-2,3-dihydroquinazolin-4(1H)-one was low for 1-butyl-1,2,4-triazolium trifluoroacetate based organocatalyst. But for substituted benzaldehyde, the yield was comparatively high. Comparatively, the yield for 2-(4-methoxyphenyl)-2,3-dihydroquinazolin-4(1H)-one, where the aromatic benzaldehyde had electron-donating group, is less than 2-(4-nitrophenyl)-2,3-dihydroquinazolin-4(1H)-one, where the aromatic benzaldehyde had an electron-withdrawing group.

Conclusion:
Substituted benzaldehyde gave better yields than benzaldehyde. And nitro group which is electrowithdrawing attached to benzaldehyde enhanced the electrophilic nature at carbonyl center showed higher yields than methoxy group which is electron donating attached to benzaldehyde as it deactivates the carbonyl carbon. The polar protic solvents like water, ethanol and methanol stabilizes the ionic intermediates and gave better yield. Even the moderately apolar solvents like DCM, chloroform resulted in good yields, green solvents like water, ethanol and methanol would be a better choice as solvents. The carbon chain on the solvent has got an effect on product yield. As the carbon chain increases in solvent, the yield decreases due to the separation difficulties. The polar aprotic solvents did gave better yields but not as good as polar protic solvents.
A Fuzzy Multi-Criteria Decision Making Methodology for Job Evaluation
Authors: Sarucan Ahmet , Söğüt Aysel , Baysal Mehmet Emin 
Published: May 2022

Aims:
In this study, the integrated methods Hesitant Fuzzy Analytic Hierarchy Process (HF-AHP), Fuzzy COmplex Proportional Assessment (F-COPRAS) and Fuzzy Technique for Order Performance to Ideal Solution (F-TOPSIS) were used for job evaluation studies in a food company.

Background:
There has been a decline in employee performance in the company. Unfair wages and unequal workload were identified as the reasons for the failure. Therefore, it has been observed that the staff turnover rate in the company is quite high.

Objective:
The objective is to determine a fair wage policy that will increase employee satisfaction by stratifying with job evaluation analysis between positions.

Methods:
The experts of Human Resources Department determined eight competency evaluation criteria for job evaluation studies in the proposed approach. Based on their judgments on these criteria, the competencies were rated using a linguistic scale and the weighting values were calculated using HF-AHP method. These values are inputs for the next stage. Employees were ranked using F-COPRAS and F-TOPSIS methods.

Results:
This study showed that the integrated method can be an effective alternative solution approach for calculating the weighting values and ranking of competencies in job evaluation studies.

Conclusion:
It has been shown that the use of the strata created as a result of this study is a great facilitator in determining employee pay policies.
Perbandingan Metode Exponential Smoothing dan Moving Average dalam Peramalan Retribusi Pengujian Kendaraan Bermotor di Dinas Perhubungan Kota Blitar
Authors: Setyowati Endah 
Published: May 2022

Analisis deret berkala (times series) merupakan salah satu model atau teknik peramalan yang banyak dilakukan dalam berbagai bidang, di antaranya analisis deret berkala pada retribusi pengujian kendaraan bermotor. Peramalan dalam retribusi pengujian kendaraan bermotor diperlukan untuk mengetahui apakah bulan selanjutnya dapat memenuhi target atau tidak. Karena besarnya retribusi pengujian kendaraan bermotor menggambarkan besar kas Dinas Perhubungan, yang dijadikan acuan penyelenggaraan rencana program-program penunjang sektor lain. Pada penelitian ini dilakukan peramalan data retribusi pengujian kendaraan bermotor pada Dinas Perhubungan Kota Blitar dengan metode exponential smoothing dan moving average yang bertujuan untuk mengetahui perbandingan keefektivitasan kedua metode tersebut dalam meramalkan retribusi pengujian kendaraan bermotor. Pada penelitian ini diperoleh hasil bahwa metode yang sesuai untuk meramalkan jumlah retribusi pengujian kendaraan bermotor Dinas Perhubungan Kota Blitar adalah metode single exponential smoothing dengan peramalan jumlah retribusi pengujian kendaraan bermotor pada bulan September 2020 sebesar Rp. 49.995.278.
Effectiveness and Utility of Virtual Reality Infection Control Simulation for Children With COVID-19: Quasi-Experimental Study
Authors: Yu Mi , Yang Mi Ran 
Published: May 2022

Background
It is essential that nurses quickly learn the proper methods for preventing and controlling nosocomial infection and managing intensive care patients during the COVID-19 pandemic, including the donning and doffing of personal protective equipment (PPE). Virtual reality (VR) simulation offers the advantage of learning in a safe environment with a sense of realism similar to that of an actual clinical setting and has been reported to enhance self-efficacy in infection control, safety performance, and learning satisfaction among students.

Objective
This study aims to develop a virtual reality infection control simulation (VRICS) program regarding donning and doffing of PPE and respiratory care for pediatric patients admitted to an isolation unit for COVID-19 and to identify the effects of the program on PPE knowledge, infection control performance, and self-efficacy for nursing students. Additionally, the realism of the VRICS program and the students’ level of satisfaction with the program were assessed.

Methods
This was a quasi-experimental study based on a controlled pretest-posttest design. Third- and fourth-year nursing students were divided into an experimental group (n=25) who participated in a VRICS program and a control group (n=25) with no participation. Data were collected from November 13 to December 10, 2021, and analyzed using descriptive statistics and the t test, paired t test, Mann-Whitney U test, and Wilcoxon matched-pair signed-rank test. The VRICS program consisted of a prebriefing, including direct practice of donning and doffing PPE, VR simulation, and debriefing. The VR simulation comprised 3 sessions: donning and inspection of PPE in the dressing room before entering the negative-pressure isolation unit; assessing for suction care, nasopharyngeal suctioning, and checking of COVID-19 patients in the negative-pressure isolation unit; and doffing PPE in the dressing room. The total execution time for the program was 180 min.

Results
Compared with the control group, the experimental group showed significantly greater improvements in PPE knowledge (z=–3.28, P<.001), infection control performance (t48=4.89, P<.001), and self-efficacy (t36.2=4.93, P<.001). The experimental group’s mean scores for realistic immersion and learner satisfaction were 4.49 (SD 0.50) points and 4.75 (SD 0.38) points (on a 5-point Likert scale), respectively.

Conclusions
The VR simulation training program involving pediatric COVID-19 patients combined skills training effectively and enhanced theoretical knowledge, respiratory care skills, and infectious disease preparedness. Thus, it could be applied to training nurses to respond more effectively to public health situations involving infectious diseases, including the COVID-19 pandemic.
Aspek Gramatikal dan Leksikal pada Lirik Lagu Jaga Slalu Hatimu Karya Grup Band Seventeen
Authors: Putri Putri Nurmala Sari , Goziyah Goziyah 
Published: May 2022

Abstrak
Penelitian ini bertujuan untuk mendeskripsikan (1) bagaimana bentuk kohesi gramatikal pada lirik lagu “Jaga Slalu Hatimu” karya Group Band Seventeen, dan (2) kohesi leksikal pada lirik lagu “Jaga Slalu Hatimu” karya Group Band Seventeen. Metode penelitian menggunakan penelitian deskriptif kualitatif. Teknik pengumpulan data menggunakan teknik dokumentasi dengan mengunduh lagu Jaga Selalu Hatimu karya Grup Band Seventeen. Hasil dan pembahasan menemukan adanya aspek gramatikal yang ditemukan berupa pengacuan (Referensi) dengan ditemukan kata aku dan kau, pelepasan (Elipsis) dengan ditemukan kata setiap, dan konjungsi (Perangkaian) dengan ditemukan kata dan. Aspek leksikal yang ditemukan adalah repetisi (Pengulangan) dengan ditemukan kata kau mampu dan kau bisa, dan sinonimi (Padanan Kata) dengan ditemukan kata mampu, bisa, mencintaimu, dan menyayangimu. Berdasarkan hasil penelitian ini, ditemukan aspek gramatikal dan aspek leksikal dalam lirik lagu Jaga Selalu Hatimu yang dinyanyikan oleh Grup Band Seventeen yang menghadirkan makna yang mendalam tentang perjalanan kisah cinta seseorang yang penuh kesetiaan akan rasa cinta kepada seseorang yang disayanginya. Aspek gramatikal dan aspek leksikal saling membangun sehingga lagu Jaga Slalu Hatimu menjadi lagu yang berkesan bagi para pendengarnya.
Kata Kunci : aspek gramatikal; aspek leksikal; lirik lagu;
Gender Equality in the Global Research Publication: The Bibliometric Review and Scientific Visualization
Authors: Abd. Rasyid Syamsul Bahri 
Published: May 2022

Despite the progress over the years, there are still many challenges to achieving basic human rights, namely “gender equality”. The language of “gender equality” was mobilized by feminists as a way to incorporate women's rights into the international development agenda. Using bibliometric analysis of scientific journal articles taken from the Scopus database, which totaled 504 journal articles, this study aims to document evidence of research activities in 2012-2021 in the Scopus database, and visualize it using VOSviewer and NVivo 12 plus software. The article reports on the publication and its citation structure, key trends, and its growing push toward co-authoring. This study also visualizes the most prominent topics and authors in the form of a network, using VOSviewer's bibliometric analysis and mapping of themes and their correlations using NVivo 12 plus. The novelty of this research is the composition of limitations in the Scopus database, as well as data processing using VOSviewer and NVivo 12 plus software. Further research, it is necessary to enrich the composition of limitations in the Scopus database, and compare it with the Web of Science database.
Therapeutic horticulture as a potential tool of preventive geriatric medicine improving health, well-being and life quality – A systematic review
Authors: Heród Anna , Szewczyk-Taranek Bożena , Pawłowska Bożena 
Published: May 2022

Abstract
The global population of older people grows systematically and with age, the physical and cognitive abilities of people decline. The amount of evidence that gardening may provide substantial health benefits and enhance the quality of ageing is increasing. This paper presents a systematic review of the therapeutic effects of horticulture and gardening on clients aged ≥60 years. It encompasses articles published in English between January 1, 2010, and December 31, 2021. The literature survey shows that the interest in the topic has grown significantly in recent years as over half of the published studies are from 2019 to 2021. Most of this work was done in Asia (60%), America, Europe, Australia and New Zealand. The most commonly used interventions were active horticultural therapy programs or gardening, but 20% of the studies explored the passive connection of being outside. The fitness of the elderly was measured using 33 psychological tests, 32 physiological and functional parameters and different kinds of self-developed questionnaires and interviews. The most commonly used psychological tests were the Geriatric Depression Scale, Self-rated Health and Quality of Life, Mini-Mental State Examination, Friendship Scale, Lubben Social Network Scale, and the Attitudes to Ageing Questionnaire. The physiological and functional parameters included heart rate variability, blood pressure, electroencephalography, brain nerve growth factors, and different types of biomarkers. The study outcomes demonstrated positive results of horticultural therapy on human health and well-being, particularly in a psychological dimension and to a smaller but still significant extent physiological aspect.
Startup Accelerators
Authors: Bańka Michał , Salwin Mariusz , Waszkiewicz Aneta Ewa , Rychlik Szymon , Kukurba Maria 
Published: May 2022

Abstract
Accelerators have been becoming increasingly popular among young entrepreneurs interested in developing products, attracting investors, or establishing relations with industry represented by large companies.
The focus of the studies is to conduct literature review due to the small number of scientific articles are available on this topic. The article aims to show the current state of knowledge about startup accelerators and the support they provide. It outlines what added value accelerators offer in their programs for young innovative companies.
To achieve the stated aim, the authors combine a systematic literature review with a bibliometric analysis. The results of this research will be helpful in better matching the developed project with existing accelerator programs on the market. It can contribute to a better understanding of the principles governing the programs, program expectations of the accelerator and its partners with respect to the proposed solutions (corporations, business angels, and venture capital funds).
THE EFFECT OF HEXAGON FRAUD ON FRAUD FINANCIAL STATEMENTS WITH GOVERNANCE AND CULTURE AS MODERATING VARIABLES
Authors: Lastanti Hexana Sri , Murwaningsari Etty , Umar Haryono 
Published: May 2022

Tujuan penelitian ini adalah untuk memperoleh bukti empiris mengenai faktor-faktor yang mempengaruhi kecurangan laporan keuangan dengan governance and culture sebagai variabel pemoderasi. Faktor-faktor pemicu kecurangan laporan keuangan menggunakan Fraud Hexagon Model (Vousinas, 2019) yang terdiri dari stimulus, opportunity, capability, rationalization, ego dan collusion. Penelitian ini menggunakan unit analisis perusahaan sektor perbankan yang terdaftar di Bursa Efek Indonesia dengan periode penelitian tahun 2014-2020. Hasil pengambilan sampel dengan menggunakan teknik purposive sampling diperoleh 231 data observasi. Hasil pengujian data empiris menunjukkan bahwa opportunity berpengaruh positif terhadap kecurangan laporan keuangan baik pada saat tidak dimoderasi maupun dimoderasi oleh governance and culture. Governance and culture memperlemah pengaruh opportunity terhadap kecurangan laporan keuangan. Namun variabel lain berupa pressure, rationalization, capability, ego/arrogance dan collusion tidak berpengaruh terhadap kecurangan laporan keuangan.

The purpose of this study is to obtain empirical evidence regarding the factors that influence financial statement fraud with governance and culture as moderation variables. Factors triggering financial statement fraud using the Fraud Hexagon Model (Vousinas, 2019) which consists of stimulus, opportunity, capability, rationalization, ego and collusion. This research uses the analysis unit of banking sector companies listed on the Indonesia Stock Exchange with a research period of 2014-2020. The results of sampling using purposive sampling techniques obtained 231 observation data. The results of empirical data testing showed that opportunity had a positive effect on financial statement fraud both when it was not moderated or moderated by governance and culture. Governance and culture weakens the influence of opportunities on financial statement fraud. But other variables in the form of pressure, rationalization, capability, ego / arrogance and collusion have no effect on financial statement fraud
Vers une gouvernance régionale du Bien-vieillir ? Des « gerontopôles » en quête de légitimité
Authors: ROGAY Raphaël 
Published: May 2022

Face au vieillissement de leur territoire et à l’augmentation de leurs capacités d’action, des acteurs locaux et régionaux se sont fédérés, à partir de 2007, afin de constituer plusieurs gérontopôles susceptibles de contribuer à la recherche clinique et à l’innovation en gérontologie. Dans cette contribution, je montre que ces organisations, peu étudiées, se sont développées autour de deux modèles aux degrés différents de légitimation : un modèle hospitalo-centré et un modèle holiste. J’analyse les ressorts de la légitimation régionale des gérontopôles holistes, tout en montrant que ces ressorts déterminent leurs contenus d’intervention. A l’échelle nationale, il apparaît finalement que si la diversité des gérontopôles gêne leur légitimation, ces difficultés sont autant le fruit de contradictions émanant du pouvoir central lui-même. En effet, l’État régulateur, enclin à encourager les territoires à développer des réponses localisées aux défis qu’ils rencontrent, peine à accorder une reconnaissance à des organisations polymorphes qui sont précisément le fruit de contextes locaux et régionaux. La recherche d’une légitimation nationale risque dès lors de conduire les gérontopôles à une homogénéisation qui fragiliserait le maintien d’une légitimité régionale durement acquise. Cette contribution s’appuie sur l’étude transversale de huit gérontopôles et sur l’étude longitudinale du gérontopôle Nouvelle-Aquitaine dont je fus un observateur participant autant qu’un participant observateur. L’enquête se fonde sur l’analyse d’un corpus de presse, d’un ensemble de documents de littérature grise, d’une dizaine d’observations participantes et de vingt-deux entretiens semi-directifs conduits dans le cadre d’une thèse de doctorat cifre.