bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mitochondrial Mutation Leads to Cardiomyocyte Hypertrophy by Disruption of Mitochondria‐Associated ER Membrane
Authors: Yu Miao , Song Min , Zhang Manna , Chen Shuangshuang , Ni Baoqiang , Li Xuechun , Lei Wei , Shen Zhenya , Fan Yong , Zhang Jianyi , Hu Shijun 
Published: February 2025

ABSTRACTm.3243A>G is the most common pathogenic mtDNA mutation. High energy‐demanding organs, such as heart, are usually involved in mitochondria diseases. However, whether and how m.3243A>G affects cardiomyocytes remain unknown. We have established patient‐specific iPSCs carrying m.3243A>G and induced cardiac differentiation. Cardiomyocytes with high m.3243A>G burden exhibited hypertrophic phenotype. This point mutation is localised in MT‐TL1 encoding tRNALeu (UUR). m.3243A>G altered tRNALeu (UUR) conformation and decreased its stability. mtDNA is essential for mitochondrial function. Mitochondria dysfunction occurred and tended to become round. Its interaction with ER, mitochondria‐associated ER membrane (MAM), was disrupted with decreased contact number and length. MAM is a central hub for calcium trafficking. Disrupted MAM disturbed calcium homeostasis, which may be the direct and leading cause of cardiomyocyte hypertrophy, as MAM enforcement reversed this pathological state. Considering the threshold effect of mitochondrial disease, mito‐TALENs were introduced to eliminate mutant mitochondria and release mutation load. Mutation reduction partially reversed the cellular behaviour and made it approach to that of control one. These findings reveal the pathogenesis underlying m.3243A>G from perspective of organelle interaction, rather than organelle. Beyond mitochondria quality control, its proper interaction with other organelles, such as ER, matters for mitochondria disease. This study may provide inspiration for mitochondria disease intervention.
Shifting Dynamics: Who Holds the Reins in Decision‐Making With Artificial Intelligence Tools? Perspectives of Gen Z Pre‐Service Teachers
Authors: Merzifonluoglu Ayse , Gunes Habibe 
Published: February 2025

ABSTRACTArtificial intelligence (AI) is significantly shaping education and currently influencing pre‐service teachers' academic and professional journeys. To explore this influence, the present study examines 389 Generation Z pre‐service teachers' attitudes towards AI and its impact on educational decision‐making at two state universities, using an explanatory sequential mixed‐methods research design. Quantitative data were collected through the General Attitudes to Artificial Intelligence Scale (GAAIS) and an AI decision‐making survey. It was followed by qualitative data gathered via semi‐structured interviews to enrich the statistical trends with deeper thematic insights. SPSS was used for quantitative data analysis while MAXQDA was employed for a systematic analysis of the qualitative data. The analysis revealed that female pre‐service teachers held more positive attitudes towards AI, with higher levels of AI knowledge contributing to these attitudes. Negative attitudes, however, were independent of gender, academic discipline or AI familiarity. Findings also reveal that AI tools, particularly ChatGPT, are primarily used as advisors, and pre‐service teachers often adapt AI's suggestions to their preferences. AI is predominantly preferred for assignments, reports, projects and presentations. In AI acceptance, time and effort savings, innovative suggestions and unbiased recommendations are stated as key factors. However, there are ongoing trust concerns highlighting the necessity of keeping final decisions under human control. Based on these findings, comprehensive AI training for teachers and students in higher education is suggested.
Revisiting Integrated Model of Technology Acceptance Among the Generative AI‐Powered Foreign Language Speaking Practice: Through the Lens of Positive Psychology and Intrinsic Motivation
Authors: Wang Chenghao , Li Xueyun , Zou Bin 
Published: February 2025

ABSTRACTResearch on the factors influencing the acceptance of GenAI in language learning has expanded widely; however, few studies have focused on the role of language learning emotions. To enhance the effectiveness of GenAI‐powered English‐speaking instruction and the learning experience, this study expands on the Integrated Model of Technology Acceptance (IMTA) by investigating the role of various emotions and willingness to communicate in different contexts as intrinsic motivators for the acceptance of GenAI‐powered conversational chatbots. Using a questionnaire (n = 368) and pre‐ and post‐tests, the study found that EFL learners with higher communicative confidence and greater foreign language learning boredom tend to perceive GenAI chatbots as less useful for developing speaking skills. While GenAI successfully aided them in improving their speaking skills through both theme‐based and free dialogues, learners who are more willing to engage in face‐to‐face interactions with peers and teachers may not find chatbots as productive or engaging as human counterparts. The results suggest that EFL teachers should be aware of the limitations of GenAI and students' individual differences, integrating GenAI into their classrooms in a way that aligns with student's proficiency and preferences to create a harmonious and efficient GenAI‐supported language learning environment. This also underscores the importance of developing teachers' AI competence in the GenAI era.
Asymmetrical knowledge: An anthropological proposal from Argentina to study how we affectedly know with others in an unequal world
Authors: García Palacios Mariana , Shabel Paülah Nurit 
Published: February 2025

AbstractKnowledge is constructed and embedded in our bodies, which means that the material conditions of our own anatomy and environment intrinsically inform our understanding, as do the social practices in which we are immersed within our communities. Cognitive and affective processes are also thus inseparable since we know together with others, always insert in asymmetrical relationships that leave a trace on our cognitive‐affective tie to the world. As Argentinean anthropologists, we contend with the ongoing effects of universalizing “Global North” psychologies in the contexts of global inequalities that impact children as well as southern researchers. Given this, the aim of this article is to present an anthropology of knowledge that puts these two effects of inequalities in dialogue while addressing the affective‐cognitive debates from South America in conversation with contributions of authors from the “Global North.” Building upon fieldwork in our home country that explores the religious formative experiences of Toba/Qom children and the political experiences of children who live in squatter buildings, we use ethnography and the clinical method of psychology to examine the diverse ways in which children form and participate in communities, and in so doing, appropriate and transform their experiences into knowledge.
Attachment Insecurity and Coparenting Relationships: An Exploration of the Effects of a Couple‐Based Intervention for New Parents
Authors: Lee Jin‐kyung , Feinberg Mark E. 
Published: February 2025

ABSTRACTDespite extensive research about adult attachment insecurity in romantic relationships and parenting behaviors, there is a noticeable gap in the literature regarding the association between prenatal attachment insecurity and establishing postnatal coparenting relationships among new parents. While recent empirical studies have shown an increasing interest in this area, research investigating the moderation on the association between attachment insecurity and coparenting relationships through preventative intervention remains limited. This study aims to investigate if a preventative couple‐focused intervention can reduce the negative effects of attachment insecurity on coparenting relationship quality. Using data from 574 new parents living in the United States, this study compares the relationship between attachment insecurity and perceived coparenting quality between the intervention and control groups. Each parent completed a pretest questionnaire before childbirth and a posttest questionnaire approximately 1 year postpartum. Multilevel model results demonstrate that new parents with higher levels of attachment avoidance in the control group, but not in the intervention group, tended to report lower quality of coparenting. This study suggests that a couple‐focused preventative intervention can benefit new parents transitioning into parenthood, especially those with higher levels of attachment avoidance. Future research may consider how to best help new parents depending on the degree and type of attachment insecurity.
Study on Bi0.9Sm0.1ScO3 regulation of Bi0.5Na0.46Li0.04TiO3‐based energy storage properties
Authors: Du Zhongrui , Yin Qiyi , Chen Chen , Si Fan , Lin Fei , Zhu Xiangyu , Zhang Yulin , Zhang Mengjun , Zu Hao , Hu Kunhong , Zhang Fulin , Shi Fukang , Li Lu 
Published: February 2025

AbstractIn this study, (1‐x)Bi0.5Na0.46Li0.04TiO3‐xBi0.9Sm0.1ScO3(BNLT‐xBSS) relaxation ferroelectric ceramics were successfully prepared by conventional solid phase method. Multiscale analyses such as XRD and EDS confirmed that these ceramics form a solid solution with a single‐phase perovskite structure. As the doping amount of Bi0.9Sm0.1ScO3 increases, a smaller grain size is obtained at x = 0.1, and the breakdown strength increases to 350 kV/cm, resulting in a higher Wrec = 5.92 J/cm3, η = 82.2%. In addition, these ceramics demonstrate other excellent properties: (1) Thermal stability, with Wrec of 2.85 ± 0.06 J/cm3 and η of 86 ± 1.2% in the temperature range of 35°C–200°C; (2) Frequency stability, with Wrec of 2.9 ± 0.05 J/cm3 and η of 85.8 ± 1.1% in the frequency range of 5–150 Hz; (3) Fast charge/discharge rate, t0.9 is about 0.18 µs. The comprehensive experiments show that the ceramic can be used as a pulse capacitor in high‐temperature environments and has great development potential.
Treatment of obesity: will incretin agonists make bariatric surgery a thing of the past?
Authors: Lah Siehoon , Hocking Samantha L. 
Published: February 2025

AbstractThe prevalence of obesity continues to increase worldwide. Obesity is associated with an increased risk of cardiometabolic and other diseases, reduced quality of life and shortened life expectancy. Highly effective therapies are required to achieve meaningful and sustained weight reduction to prevent, slow or reverse disease associated with obesity. Bariatric surgery is a highly effective intervention to induce weight loss, with observational data demonstrating durability of weight loss over 10 or more years. In addition, bariatric surgery improves cardiometabolic risk factors, including hyperglycaemia and type 2 diabetes, hypertension and dyslipidaemia. Observational data have shown a reduction in all‐cause mortality, cardiovascular events and mortality and a reduction in cancer risk and mortality in patients who have undergone bariatric surgery compared to matched patients who did not have surgery. The emergence of newer incretin agonists, particularly semaglutide and tirzepatide, have demonstrated remarkable efficacy in inducing and maintaining weight loss with ongoing use. As for bariatric surgery, incretin agonist therapies also improve type 2 diabetes outcomes, cardiovascular mortality and other obesity‐related complications, with new evidence emerging and long‐term outcome data awaited. This perspective compares bariatric surgery and incretin agonist therapy, assessing their relative efficacies in weight reduction, impact on obesity‐related complications, their respective risk profiles and considerations of cost‐effectiveness and equity of access. These comparisons seek to evaluate whether these increasingly popular medications could make bariatric surgery a thing of the past.
The Cystic Fibrosis Transmembrane Conductance Receptor Brakes Allergic Airway Inflammation
Authors: Cook Daniel P. , Peebles R. Stokes 
Published: February 2025

ABSTRACTCystic fibrosis (CF) is a common autosomal recessive disease resulting from mutations of the gene that encodes the cystic fibrosis transmembrane conductance regulator (CFTR). Although severe pulmonary neutrophilic inflammation is a primary pathologic feature of CF, more recent studies reveal a role for type 2 inflammation that is characterized by eosinophilia directed by both the innate and adaptive immune systems through ILC2 and CD4+ Th2 cells, respectively. We have published that a clear type endotype exists within CF subjects stratified by Th2 inflammation, defined by increased obstructive pulmonary disease and a distinct phenotypic signature of increased allergic disease, infections, and burden of CF complications. Further, we showed an increased risk of death among CF subjects with type 2 inflammatory signatures compared to CF subjects lacking significant type 2 inflammation. The mechanisms of this heightened type 2 inflammatory signature in CF are still being defined, but it is clear that airway epithelial cells from CFTR‐deficient mice have increased expression and release of IL‐33, a key activator of ILC2 and Th2 cells, compared to persons with normal CFTR function. Further, there is strong evidence that CF regulates CD4+ Th2 function in a cell‐intrinsic fashion. These concepts are explored in this review article.
Digital Wings: The Effect of Digital Technology Adoption on Market Power
Authors: Tang Haodan , Xu Gang 
Published: February 2025

ABSTRACTThis paper evaluates the causal impact of digital technology adoption (DTA) on firms' market power using data from Chinese listed manufacturing companies. Employing staggered difference‐in‐differences strategies, we find compelling evidence that DTA has a significant and substantial positive impact on market power. We also find supportive evidence for several underlying channels through which this impact occurs: improved research and development intensity, the upgrading of human capital structure, enhanced manufacturing servitization, and increased external attention. Furthermore, we establish an inverted U‐shaped relationship between the share of DTA firms and resource misallocation within the industry‐province dimension. This study contributes to the existing literature on the digitalization paradox by extending the investigation of the market performance of digital transformation to the context of developing countries.
Population Biology of Begomovirus Viruliferous Whiteflies (Bemisia tabaci) and Its Associated Endosymbionts in the Cucurbitaceous Ecosystem of Tamil Nadu, India
Authors: Sivagnanapazham Kathiresan , Karthikeyan Gandhi , Harish Sankarasubramanian , Murugan Marimuthu , Devi Harinarayanan Usha Nandhini 
Published: February 2025

ABSTRACTThe sweet potato whitefly, Bemisia tabaci (Gennadius) (Hemiptera: Aleyrodidae) is a polyphagous, phloem sap‐feeding pest of highly economically important crops. This pest infests more than 600 horticultural and agricultural crops. It is thought to be a complex of physically similar cryptic species with variations in their genetic, physiological and biological characteristics. In the present study, the incidence of the cryptic species B. tabaci and the viruliferous nature of whiteflies with begomovirus in cucurbitaceous crops from seven agroclimatic zones of Tamil Nadu were assessed. Based on the available sequence data, we report the occurrence of four major cryptic species of whiteflies recorded in Tamil Nadu. The identified cryptic species of B. tabaci, viz., Asia I, Asia II (5), Asia II (7) and Asia II (8) were observed in all 22 locations in Tamil Nadu. The predominant occurrence of B. tabaci Asia I was recorded in three agroclimatic zones, viz., the western, north western and high‐rainfall zones of Tamil Nadu. Asia II (5) was detected in all six agroclimatic zones, while Asia II (8) was detected in the western, north western and southern zones of Tamil Nadu. Asia II (7) was the only cryptic species recorded in the western zone of Tamil Nadu. Studies on endosymbiont associations with these whiteflies revealed the presence of Portiera (PP593660), Fritchea (PP600138), Cardinium (PP600148), Hamiltonella (PP593664), Wolbachia (PP593662) and Rickettsia (PP590220) in the reported cryptic species of B. tabaci. Hap_2, hap_14, hap_35, hap_42, hap_79 and hap_80 were the haplotypes of B. tabaci on cucurbitaceous crops in Tamil Nadu. Asia II (5) exhibited the highest haplotype diversity, and Asia I showed a high level of nucleotide diversity. These results will be useful for understanding outbreaks of B. tabaci and developing efficient management strategies for viruses that are transmitted by B. tabaci.
Invasive and Native Non‐Crop Plants Support Aphidophagous Insects in Chilli Pepper Agroecosystems
Authors: Melo‐Cerón Clara‐Inés , Martínez‐Falcón Ana Paola , Quijano Joel , Duque‐Gamboa Diana N. , Toro‐Perea Nelson , Manzano Maria R. 
Published: February 2025

ABSTRACTUnderstanding the complex interactions between aphids, their natural enemies and surrounding plants is crucial to effectively manage pest aphids in Capsicum crops. While it is known that aphidophagous communities can be found both within and around Capsicum crops, which specific plant species support these beneficial insects remains largely unknown. This study aimed to identify key plant species that could be conserved to promote natural pest control. We sampled and identified pest and non‐pest aphids, as well as aphidophagous insects, for over 3 years in 30 Capsicum crops and surrounding non‐crop vegetation in Colombian chilli pepper agroecosystems. By combining field observations with molecular techniques, we determined plant‐insect associations and the trophic structure of the community. We found that the presence of crop flowers and fruits led to nestedness in plant‐insect interaction networks, while flowering crops alone resulted in modularity in the plant‐aphid network. A core group of plant and insect species, including Capsicum, the invasive weed Sorghum halepense, the native plants Parthenium hysterophorus and maize (Zea mays), and various aphid and generalist aphidophagous species, formed the most significant interactions within the network. These findings suggest that a diverse plant community, including both native and invasive species, can enhance aphidophagous insect populations and provide a foundation for sustainable pest management strategies in chilli pepper agroecosystems.
Skin development in the gray short‐tailed opossum (Monodelphis domestica)—From skin respiration to thermoregulation
Authors: Ferner Kirsten 
Published: February 2025

AbstractMarsupials are born at an early stage of development, and compared to eutherians, skin development is slow, and a functional change during skin ontogenesis occurs. The skin development in 36 gray short‐tailed opossums (Monodelphis domestica) has been examined using histological, morphometric, and μCT methods during postnatal development from neonate to adult. The aim of the study is to follow the structural and functional transition of the skin in this immature marsupial species. Additionally, the postnatal development of the external appearance and the cardiac and respiratory systems is looked at to assess skin development in relation to the general development. The skin of the newborn gray short‐tailed opossum is thin and undifferentiated (no hair follicles, no sebaceous and sweat glands). Numerous subepidermal capillaries allow for gaseous exchange via the skin. A dense cutaneous capillary net with a high capillary volume density (0.25 ± 0.04) is present at term, indicating significant cutaneous gas exchange in the neonate. The capillary volume density decreases markedly during the first postnatal week (0.08 ± 0.01). In the same time period, the skin diffusion barrier increases from 27 ± 4 to 87 ± 1 μm. From this age on, the skin development is characterized by thickening of the different cutaneous layers and beginning formation of hair follicles. First, hair covering the skin, sweat glands, and subcutaneous fat are observed by day 28, indicating the onset of thermoregulation. The total skin thickness in the gray short‐tailed opossum increases from 58 μm at birth to 726 μm by day 35, when the pelage is fully developed. The cardiac and respiratory systems are immature at birth. A fenestrated interatrial septum is present for the first 4 days, allowing skin respiration. Between day 4 and day 7, the lung enters the saccular stage of lung development and is mature enough to meet the respiratory needs of the growing organism. During a long period of postnatal development, the structural differentiation of the skin results in a functional shift from transcutaneous gas exchange to thermoregulation in later life.
Perceptions of procedural fairness and space for personal narrative: an experimental study of form design
Authors: MEERS JED , RYAN AISLING , TOMLINSON JOE 
Published: February 2025

AbstractApplication forms – the most mundane of documents – are often the compulsory interface between an individual and the state. From social security and immigration, to health and social care, application forms are ubiquitous across almost all areas of government bureaucracy. However, socio‐legal research on administrative justice tends to examine these forms from the perspective of front‐line decision makers, instead of form fillers. Drawing on a survey experiment with 655 recipients of Universal Credit (a means‐tested social security benefit) in the United Kingdom, we demonstrate how the inclusion of space for personal narrative in a local welfare application form – the ability to set out one's circumstances in full – significantly increases perceptions of procedural fairness. Our findings demonstrate how seemingly small changes to form design can have a considerable impact on the perceived fairness of an application process and the importance of grounding administrative justice research in the experiences of people who regularly interact with the administrative processes of the state.
The Automated Subcutaneous Implantable Cardioverter‐Defibrillator Screening in Patients With Leadless Pacemakers
Authors: Dyrbuś Maciej , Machowicz Joanna , Kurek Anna , Gąsior Mariusz , Tajstra Mateusz 
Published: February 2025

ABSTRACTBackgroundThe number of leadless pacemakers (LPMs) implantations has seen a major growth in recent years. Indications for LPMs often overlap with indications for subcutaneous implantable cardioverter‐defibrillators (sICDs), as they are mostly recommended in patients in whom transvenous devices are deemed ineligible or contraindicated. Before sICD implantation, the patient should pass screening to verify the stability of QRS morphology in intrinsic and paced rhythms. The aim of this study was to evaluate the percentage of positive sICD screening in patients with a previously implanted LPM and evaluate the concordance between the vectors during the intrinsic and paced rhythm.MethodsTwenty‐two patients who underwent implantation of the ventricular LPM from May to October 2024 were included in the present study. After the implantation, automated sICD screening was performed using the dedicated system, across 2–4 body positions, both during intrinsic and paced rhythms, in nominal, and emergency output.ResultsAll patients had the devices implanted in the interventricular septal location. Screening for QRS indicated that 94.1% of patients fulfilled the criterion for implantation of sICD in at least one vector during intrinsic rhythm, while only 23.8% and 28.5% passed screening during nominal and emergency pacing outputs, respectively. Positive screening concordance in at least one vector was observed in 23.5% of patients.ConclusionsDespite almost all patients having undergone successful screening during intrinsic rhythm, the low rates of positive QRS assessment were observed during pacing, what might raise potential concerns for an optimal coexistence of LPM and sICD in daily clinical practice.