bluuebunny/crossref_metadata_2025_split huggingface dataset:
No Association Between Donor Variables and Clinically Significant Outcomes, Reoperations, and Failure After Osteochondral Allograft Transplantation
Authors: Hevesi Mario , Wagner Kyle R. , Quigley Ryan A. , Meeker Zach D. , Yazdi Allen A. , Weissman Alexander C. , Muth Sara A. , Cohen Nate S. , Yanke Adam B. , Cole Brian J. 
Published: January 2025

Background: Mismatch between osteochondral allograft (OCA) donor and recipient sex has been shown to negatively affect outcomes. This study accounts for additional donor variables and clinically relevant outcomes. Purpose: To evaluate whether donor sex, age, donor-recipient sex mismatch, and duration of graft storage affect clinical outcomes and failure rates after knee OCA transplantation. Study Design: Cohort study; Level of evidence, 3. Methods: Patients undergoing knee OCA transplantation between 2003 and 2018 were prospectively followed. Inclusion criteria consisted of primary OCA transplantation and minimum 2-year follow-up. Patient descriptive data and allograft donor sex, age, and graft storage time before implantation were collected. Patients were evaluated for reoperation, failure, and achievement of clinically significant outcomes for International Knee Documentation Committee scores. Reoperation was defined as subsequent surgical intervention of the transplanted allograft, including second-look arthroscopy for graft evaluation, debridement, and loose body removal. Failure was defined as revision of the primary OCA transplantation or conversion to arthroplasty. A Kaplan-Meier curve determined cumulative survivability of OCA transplantations, and log-rank testing was used to compare survivorship between groups. Stepwise regression analysis was utilized to evaluate associations between donor variables and achievement of clinically significant outcomes, reoperation, and failure. Results: A total of 372 patients undergoing OCA transplantation were included and followed for a mean 5.4 years (SD, 2.7; range, 2.0-16.3). Isolated OCA transplantation was performed in 45% of cases (169/372). A mismatch in donor and recipient sex was present for more female patients (90%) than male patients (10%; P < .001). Those who had a sex-mismatched graft more frequently underwent concomitant tibial tubercle osteotomy ( P = .034). When controlling for patient sex, no other differences were seen between groups matched and mismatched by sex. Univariable and multivariable analysis found no significant difference in survival free from reoperation or failure on the basis of donor-recipient sex mismatch, donor age, or graft storage time before implantation. Conclusion: In contrast to previous historical data, no donor variables were associated with inferior clinical outcomes in patients who underwent OCA transplantation. These data can help inform graft selection, expedient recipient selection, and outcome optimization after OCA transplantation.
Screening approaches and potential of isolated lactic acid bacteria for improving fermentation of Saccharina latissima
Authors: Zioga Evangelia , Holdt Susan Løvstad , Gröndahl Fredrik , Bang-Berthelsen Claus Heiner 
Published: January 2025

Abstract
Background
With the growing interest in applying fermentation to seaweed biomasses, there is a need for fast and efficient selection of microbial strains that have the ability to 1) acidify quickly, 2) utilize seaweed constituents and c) exhibit some proteolytic activity. The present study aims to provide a fast methodology to screen large bacterial collections for potential applications in optimized seaweed fermentations, as well as investigate and assess the performance of a selected bacterial collection of the National Food Institute Culture Collection (NFICC) in seaweed fermentation. This approach is directed toward high-throughput (HT) methodologies, employing microwell assays for different phenotypical characteristics of lactic acid bacteria isolated from different sources. The overarching aim is the deeper understanding of the selection criteria when designing starter cultures for seaweed fermentation.

Results
By employing high-throughput analytical workflows, the screening processing time is minimized, and among the different strains from a well-characterized strain collection, it was possible to distinguish between strong acidifiers and to replicate similar results when the volumes were scaled from 96-well plates to lab-scale fermentations (40 mL) of whole seaweed. Lactiplantibacillus plantarum, Lacticaseibacillus paracasei and, to a lesser extent, Lacticaseibacillus rhamnosus were among the fastest strains to reach the lowest endpoint pH values (< 4.5) in less than 48 h. Although the results regarding proteolytic capacity were not sufficient to prove that the candidates can also provide some flavor generation by the cleavage of proteins, NFICC1746 and NFICC2041 exhibited potential in releasing free alanine, glutamate and asparate as free amino acids.

Conclusions
With the described methodology, a large number of terrestrial lactic acid bacteria (LAB) isolates were screened for their performance and possible application for fermentation of brown sewaeeds. With a a fast conversion of sugars to organic acids, three potential new plant-isolated strains from NFICC, specifically Lactiplantibacillus plantarum ssp. argentoratensis (NFICC983), Lacticaseibacillus paracasei (NFICC1746) and Lacticaseibacillus rhamnosus (NFICC2041), were identified as promising candidates for future synthetic consortia aimed at application in bioprocessed seaweed. The combination of such strains will be the future focus to further optimize robust seaweed fermentations.
Positron emission tomography tracers for synucleinopathies
Authors: Xiang Jie , Zhang Zhentao , Wu Shengxi , Ye Keqiang 
Published: January 2025

AbstractSynucleinopathies, such as Parkinson’s disease, dementia with Lewy bodies, and multiple system atrophy, are characterized by the aggregation of α-synuclein. Variations in brain distribution allow for differentiation among these diseases and facilitate precise clinical diagnosis. However, distinguishing between synucleinopathies and Parkinsonism with tauopathies poses a challenge, significantly impacting clinical drug development. Therefore, molecular imaging is crucial for synucleinopathies, particularly for clinical diagnosis, assessment of drug efficacy, and disease surveillance. In recent years, advances in molecular imaging have led to rapid development of α-synuclein-specific tracers for positron emission tomography (PET), most of which are still in pre-clinical stages. Interestingly, some of these tracers share similar compound skeletal structures and are currently undergoing optimization for clinical application. Despite this progress, there remain challenges in developing α-synuclein tracers. This review summarizes recent findings on promising PET tracers and discusses representative compounds’ characteristics while offering suggestions for further research orientation.
Performance Evaluation of Torque-Controlled Expansion Anchors with Improved Sleeve and Header Details
Authors: Hur Moo-Won , Chae Kyoung-Hun , Lee Hyun-Ho , Park Tae-Won 
Published: January 2025

Abstract
This study assesses improvements in the head and extension sleeve parts for a post-installed anchor. The sleeve and head details were proposed to enhance the structural performance of the post-installed anchor, and the optimal structural shape was determined through finite element analysis. The analysis results revealed that the anchor's performance was most efficiently improved when the sleeve length was 9.0 mm and the head length was 3.0 mm. In the model with these dimensions applied, the performance improved approximately 1.71 times compared to the existing model, validating the effectiveness of the proposed structural details. The improved pull-out strength test of anchor diameter M12 showed an increase of 1.25 times in normal-strength concrete and 1.28 times in high-strength concrete, with an embedded depth of 50 mm. The improved pull-out strength test of anchor diameter M16 showed that the pull-out strength increased by 1.42 times for normal-strength concrete and about 1.33 times for high-strength concrete. This research proposes a modified equation that reflects changes in the effective embedded depth and diameter. A comparison of the proposed equation with that of European Technical Approval Guideline (ETAG) showed that the correlation coefficient changed from 0.908 to 0.962, and the coefficient of variation changed from 18.9 to 10.4%, meaning that the proposed equation reflected the actual experimental values more accurately.
Asymmetries in factors influencing non-fungible tokens’ (NFTs) returns
Authors: Benedek Botond , Nagy Bálint Zsolt 
Published: January 2025

AbstractThe asymmetries of factors influencing the return of cryptocurrencies have already been well documented; however, in the case of NFTs, only information asymmetries and hedging properties related to asymmetries were studied. Therefore, the present study examines factors affecting NFT returns, from market-related factors (crypto-market index return and stock market index return) to the Amihud illiquidity ratio and Google search trends during different market conditions. The wavelet coherences-based methodology was applied separately during the boom, bust, normal, and turbulent periods identified by structural breakpoints. Based on 14 NFT projects between April 2019 and July 2022, results show two fundamental asymmetries influencing these NFT returns. First, there is an asymmetry in the behavior of the factors in different periods; second, there is an asymmetry in how illiquidity manifests itself over NFTs that do or do not possess cash flow-generating potential.
Experimental and numerical investigation into pile spacing effects on the dynamic response of coastal pile foundation bridges considering current-wave-earthquake forces
Authors: Alsultani Riyadh , Karim Ibtisam R. , Khassaf Saleh I. 
Published: January 2025

AbstractPile spacing significantly influences the dynamic response of coastal pile foundation bridges, particularly under complex loading conditions. This study presents a novel methodology for optimizing the distribution of piles within a nine-pile cap and evaluates the effects of varying pile spacings on the dynamic fluid-structure interaction. An experimental investigation was conducted to assess the dynamic response of three scaled bridge specimens with pile spacings of 2.5D, 2.0D, and 1.5D (where D is the pile diameter) under combined current-wave forces during seismic events. The acceleration and displacement responses were measured using the innovative Reality Water Structure Earthquake Interaction Test (RWSEIT) system. The results revealed that reduced pile spacing (1.5D) led to a significant increase in both acceleration and displacement responses, indicating higher vulnerability under dynamic loading. In contrast, wider spacing (2.5D) demonstrated improved stability, with reduced displacement and acceleration, thereby enhancing the overall structural resilience. The analysis also highlighted the critical role of water depth, current velocity, and wave properties in modulating the dynamic response. Complementary 3D numerical models were developed using the Finite Element DIANA Software, and the numerical results closely matched the experimental findings, thereby validating the model’s accuracy. These insights contribute to more sustainable infrastructure design, aligning with global efforts to enhance the resilience and longevity of coastal structures while minimizing environmental impact. These findings provide crucial insights into the fluid-structure interactions of coastal bridges, offering practical guidance for the design and assessment of deepwater pile foundations under seismic and hydrodynamic forces.
Secure Digital Data Visual Sharing Schemes in Multi-Owner Public Cloud Environment Applications
Authors: Chekka Ratna Babu , Babu B Ravindra 
Published: January 2025

The use of cloud computing for storing and processing cyber data via the internet has grown widespread in the field of cyber security. Ensuring the secure sharing of cyber data, including texts, images, audio, and video, over the cloud is paramount. However, cloud computing encounters significant challenges concerning cyber data security, authentication, and privacy. The prevailing approaches to data security encounter challenges such as the generation of intricate keys, intensive computation for large keys, and susceptibility to attacks by intruders. Scalability presents its own set of obstacles in maintaining cyber data privacy and ensuring secure communication. A significant privacy concern arises from the frequent changes in membership and data sharing among multiple owners. This paper introduces a novel approach to secure data sharing within data centres by proposing a scheme that employs Private Key Dynamic Visual Cryptography (PK-DVC), Multiple Key Encryption Visual One-Time Pad (MK-VOTP), and visual steganography for encoding and decoding. MK-VOTP is used for data encryption, facilitating data owners' encryption via utilising their identity with supplementary security features. Subsequently, the encrypted data is kept in the cloud, guaranteeing heightened security protocols. Visual steganography is employed for further authentication purposes. Decrypting the original data requires users who fulfil the encrypted properties. This increases security and reduces critical size, allowing several authenticated owners to share data without conflicts. Combining all shares recreates the original picture. The approach described in the paper sounds innovative and addresses several key challenges in ensuring secure data sharing within data centers, particularly in the context of cloud computing. The proposed scheme main components are Private Key Dynamic Visual Cryptography (PK-DVC), Multiple Key Encryption Visual One-Time Pad (MK-VOTP), and Visual Steganography. These three components plays important role in further authenticating the encrypted data or providing additional security measures beyond encryption. By combining these techniques, the proposed scheme aims to provide robust security for sharing cyber data in cloud environments. The use of dynamic keys, multiple encryption layers, and steganography can enhance data security, making it challenging for intruders to access or decipher sensitive information.
Potential benefits of GLP-1 analogues and metformin in patients with osteoarthritis
Authors: Skowronek Anna , Piekarska Martyna , Dąbek Katarzyna , Ochwat Michał , Sudoł Maria , Mierzwa Gabriela , Kajtel Aleksandra , Skowronek Tomasz 
Published: January 2025

Introduction and purpose
Osteoarthritis (OA) is the most prevalent chronic joint disorder. It is the primary cause of chronic pain. Known risk factors for OA include obesity and type 2 diabetes mellitus (T2DM). One of the challenges in managing OA is the absence of disease-modifying treatments. Since obesity is an independent risk factor of OA, the use of medications like GLP-1 analogs and metformin may benefit patients with OA. The purpose of our article was to provide an overview of the findings from studies on the use of the mentioned drugs in OA patients.

Materials and methods
To write this article, databases such as PubMed and Google Scholar were searched using the following terms: osteoarthritis, glucagon-like peptide-1 (GLP-1), obesity, anti-obesity medications.

Description of the state of knowledge
Research on the effects of GLP-1 analogs in OA patients has yielded inconclusive results. Some studies showed that semaglutide provided benefits in reducing knee osteoarthritis symptoms in obese, nondiabetic patients. For those with knee OA and T2DM, GLP-1 receptor agonists lowered body weight and pain intensity. Furthermore, patients treated with GLP-1 receptor agonists have a reduced risk of knee surgery and lower cartilage loss velocity. Patients receiving semaglutide who underwent arthroplasty procedures experienced lower risks of prosthetic infections and hospital readmissions. The use of metformin was associated with reduced rates of joint replacement surgery.

Conclusions
GLP-1-based therapies and metformin, due to their pleiotropic effects, may provide advantages by alleviating joint inflammation and facilitating weight loss in OA patients. Additional research is required to validate these outcomes and identify the most effective treatment approaches for managing OA.
Crossing Borders, Opening Minds? VET Tandem Partnerships in a Dutch- German Cross-Border Region
Authors: Wilde Stephanie , Kremer Hugo , Stelzer Jana 
Published: January 2025

Purpose: The purpose of this paper is to discuss the potential contribution of cross-border vocational education and training (VET) exchange partnerships within the context of tandem exchanges between VET institutions in the Rhine-Waal Euregio region in the Netherlands and Germany. These tandem exchanges offer learners and teachers in VET the opportunity to develop new perspectives on their training pathways, the labour market and learning approaches in each context respectively. This occurs through the discussion and debate ignited by the exchanges, as well as through visits to relevant VET institutions, companies and other institutions in the border region.
Approach: The approach taken in the paper uses both documentary analysis of a long-standing cross-border VET network, Ler(n)ende Euregio, as well as an interview-based study. Group interviews were held with teachers and school leadership teams from three tandem partnerships in North-Rhine Westphalia and the Netherlands, namely in the Rhine-Waal border region. The interviews revealed aspects of the motivation for the tandems and the challenges involved.
Findings: The findings showed that learning opportunities for the students and the teachers are considerable and include: Gaining an insight into their vocational training pathway in the neighbouring country, and thereby reflecting on their own VET experience; developing social, intercultural and linguistic competences. This occurs particularly because of the switch between host and guest modes. Further, such exchanges can play a role in tackling prejudice in both cross-border contexts. Challenges faced by the tandem partnerships include: Maintaining continuity in the participating VET institutions and the teachers responsible for the exchanges and overcoming logistical and bureaucratic hurdles. Greater recognition of cross-border exchanges through certification for learners and dedicated time on the curriculum could be positive steps.
Conclusion: The paper concludes that tandem partnerships in the Dutch-German border region offer a sustainable and accessible addition to the palette of mobilities available to learners and, significantly, also to teachers, in VET. The potential, particularly for learners who may not otherwise travel abroad during their training, is considerable, and is arguably relevant to other cross-border regions and international contexts.
The Role of Higher Education Through the Eyes of Hungarian Undergraduate Students and Graduates: A Qualitative Exploratory Study
Authors: Kocsis Zsófia , Pusztai Gabriella 
Published: January 2025

Context: Most education systems equip graduates with the professional knowledge and cognitive skills needed to enter the world of work. However, there are other competencies also important for young graduates to become successful employees. Due to the growing uncertainty that characterizes the labour market, the demand for non-cognitive skills (communication, collaboration, critical thinking etc.) that support employee development potential and better integration has increased significantly. However, higher education institutions often transmit a culture that is different from that of workplaces. The aim of our study is to explore the role of the examined higher education institution in preparing students for the labour market. Our long-term goal is to support institutional development on the basis of this data.
Methods: To answer these questions, semi-structured inteviews were conducted. Qualitative research methods were preferred, which offer the possibility of uncovering hidden mechanisms. The selection criterion for participants (n=18) was that they had obtained their diploma within the last three years, while, for the other portion of the interviewees, a selection criterion was that they were full-time students. The participants are students of the same rural higher education institution. To ensure the validity and reliability of the research results, personal triangulation was validated using the intercoding technique, which is suitable for a priori coding.
Results: The results confirmed that higher education institutions provide a good foundation for entering to the labour market, but the development of broad competencies is less advanced. Frequent reference was made to the dominance of theory at the expense of practical orientation. Additionally, participants emphasized that they did not see relevance of the course material and its future applicability to the labour market, and, in some cases, they mentioned problems relating to the attitudes of instructors and the quality of the training provided for the students. A portion of the undergraduate students who work (in addition to being in school) believe that they acquired the most important skills during student employment and not during their higher education studies.
Conclusions: One of the challenges for higher education is to prepare students to meet employers' needs by developing students’ competencies. During their years in higher education, students should be equipped with a set of competencies that will ensure their integration into the labour market. Our current research contributes to this goal by mapping the competencies, and highlighting where there is room for improvement which can contribute to graduates' success at work.