bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evidence of altered fatty acid metabolism in dogs with naturally occurring valvular heart disease and congestive heart failure
Authors: Wilshaw Jenny , Boswood A. , Chang Y. M. , Sands C. J. , Camuzeaux S. , Lewis M. R. , Xia D. , Connolly D. J. 
Published: May 2022

AbstractIntroductionMyxomatous mitral valve disease (MMVD) is the most common cardiac condition in adult dogs. The disease progresses over several years and affected dogs may develop congestive heart failure (HF). Research has shown that myocardial metabolism is altered in cardiac disease, leading to a reduction in β-oxidation of fatty acids and an increased dependence upon glycolysis.ObjectivesThis study aimed to evaluate whether a shift in substrate use occurs in canine patients with MMVD; a naturally occurring model of human disease.MethodsClient-owned dogs were longitudinally evaluated at a research clinic in London, UK and paired serum samples were selected from visits when patients were in ACVIM stage B1: asymptomatic disease without cardiomegaly, and stage C: HF. Samples were processed using ultra-performance liquid chromatography mass spectrometry and lipid profiles were compared using mixed effects models with false discovery rate adjustment. The effect of disease stage was evaluated with patient breed entered as a confounder. Features that significantly differed were screened for selection for annotation efforts using reference databases.ResultsDogs in HF had altered concentrations of lipid species belonging to several classes previously associated with cardiovascular disease. Concentrations of certain acylcarnitines, phospholipids and sphingomyelins were increased after individuals had developed HF, whilst some ceramides and lysophosphatidylcholines decreased.ConclusionsThe canine metabolome appears to change as MMVD progresses. Findings from this study suggest that in HF myocardial metabolism may be characterised by reduced β-oxidation. This proposed explanation warrants further research.
Histological and Top-Down Proteomic Analyses of the Visual Pathway in the Cuprizone Demyelination Model
Authors: Almuslehi Mohammed S. M. , Sen Monokesh K. , Shortland Peter J. , Mahns David A. , Coorssen Jens R. 
Published: May 2022

Abstract
A change in visual perception is a frequent early symptom of multiple sclerosis (MS), the pathoaetiology of which remains unclear. Following a slow demyelination process caused by 12 weeks of low-dose (0.1%) cuprizone (CPZ) consumption, histology and proteomics were used to investigate components of the visual pathway in young adult mice. Histological investigation did not identify demyelination or gliosis in the optic tracts, pretectal nuclei, superior colliculi, lateral geniculate nuclei or visual cortices. However, top-down proteomic assessment of the optic nerve/tract revealed a significant change in the abundance of 34 spots in high-resolution two-dimensional (2D) gels. Subsequent liquid chromatography-tandem mass spectrometry (LC-TMS) analysis identified alterations in 75 proteoforms. Literature mining revealed the relevance of these proteoforms in terms of proteins previously implicated in animal models, eye diseases and human MS. Importantly, 24 proteoforms were not previously described in any animal models of MS, eye diseases or MS itself. Bioinformatic analysis indicated involvement of these proteoforms in cytoskeleton organization, metabolic dysregulation, protein aggregation and axonal support. Collectively, these results indicate that continuous CPZ-feeding, which evokes a slow demyelination, results in proteomic changes that precede any clear histological changes in the visual pathway and that these proteoforms may be potential early markers of degenerative demyelinating conditions.
Towards digital organized crime and digital sociology of organized crime
Authors: Di Nicola Andrea 
Published: May 2022

AbstractAs technology has changed people’s lives, criminal phenomena are also constantly evolving. Today’s digital society is changing the activities of organized crime and organized crime groups. In the digital society, very different organized crime groups coexist with different organizational models: from online cybercrime to traditional organized crime groups to hybrid criminal groups in which humans and machines ‘collaborate’ in new and close ways in networks of human and non-human actors. These criminal groups commit very different organized crime activities, from the most technological to the most traditional, and move from online to offline. They use technology and interact with computers for a variety of purposes, and the distinction between the physical and virtual dimensions of organized crime is increasingly blurred. These radical developments do not seem to be accompanied by a new criminological theoretical interpretive framework, with a definition of organized crime that is able to account for the changes that digital society brings to organized crime and generate modern research hypotheses. This article proposes the concept of digital organized crime and the spectrum theory of digital organized crimes, to be embedded within a current, revised sociological theory of the organization of crime and deviance in digital society (a new theory of digital criminal organizing) and argues that the study of digital organized crime will increasingly require a digital sociology of organized crime. Criminologists are called upon to work in this direction.
User requirements for the design of smart homes: dimensions and goals
Authors: Reisinger Michaela R. , Prost Sebastian , Schrammel Johann , Fröhlich Peter 
Published: May 2022

AbstractThe ‘Smart Home’ is a strongly technology-driven field. While user-centered requirements have been reported for specific features, a considerable gap persists for design based on an everyday home context and the social and emotional nature of the home. To address this, we present a user-centered design process to question and expand narrow framings of energy-efficiency and smart control and consider the richness and variety of the domestic context as design space for smart homes. Our three-step investigation employs cultural probing, participatory design fiction, and focus groups to progress from the home context “as-is” towards a blending of values with technological responses. Our findings highlight the home as a complex construct imbued with organically grown practices and individual and collective needs, values, and emotions. Based on empirical, real-user data we present features and system expectations that address this multifaceted overall picture. This paper advises the design process of future smart home solutions in three facets: first, we discuss the value of the design process applied in this study and future possibilities to expand. Second, we show design dimensions, namely time, space, relations, individual factors, and values that allow design for a heterogeneity of users and situations. Third, we derive specific design goals to highlight directions of smart home system design: design for control, low effort, integration, evolvability, identity, sociability, and benefits.
The Language of Compassion: Hospital Chaplains’ Compassion Capacity Reduces Patient Depression via Other-Oriented, Inclusive Language
Authors: Mascaro Jennifer S. , Palmer Patricia K. , Willson Madison , Ash Marcia J. , Florian Marianne P. , Srivastava Meha , Sharma Anuja , Jarrell Bria , Walker Elizabeth Reisinger , Kaplan Deanna M. , Palitsky Roman , Cole Steven P. , Grant George H. , Raison Charles L. 
Published: May 2022

Abstract

Objectives
Although hospital chaplains play a critical role in delivering emotional and spiritual care to a broad range of both religious and non-religious patients, there is remarkably little research on the best practices or “active ingredients” of chaplain spiritual consults. Here, we examined how chaplains’ compassion capacity was associated with their linguistic behavior with hospitalized inpatients, and how their language in turn related to patient outcomes.

Methods
Hospital chaplains (n = 16) completed self-report measures that together were operationalized as self-reported “compassion capacity.” Next, chaplains conducted consultations with inpatients (n = 101) in five hospitals. Consultations were audio-recorded, transcribed, and analyzed using Linguistic Inquiry Word Count (LIWC). We used exploratory structural equation modeling to identify associations between chaplain-reported compassion capacity, chaplain linguistic behavior, and patient depression after the consultation.

Results
We found that compassion capacity was significantly associated with chaplains’ LIWC clout scores, a variable that reflects a confident leadership, inclusive, and other-oriented linguistic style. Clout scores, in turn, were negatively associated with patient depression levels controlling for pre-consult distress, indicating that patients seen by chaplains displaying high levels of clout had lower levels of depression after the consultation. Compassion capacity exerted a statistically significant indirect effect on patient depression via increased clout language.

Conclusions
These findings inform our understanding of the linguistic patterns underlying compassionate and effective chaplain-patient consultations and contribute to a deeper understanding of the skillful means by which compassion may be manifest to reduce suffering and enhance well-being in individuals at their most vulnerable.
A novel and diverse set of SNP markers for rangewide genetic studies in Picea abies
Authors: Mader Malte , Blanc-Jolivet Céline , Kersten Birgit , Liesebach Heike , Degen Bernd 
Published: May 2022

AbstractWe used Double Digest Restriction site associated DNA sequencing (ddRADseq), exome sequencing (exome-seq) and targeted genotyping by sequencing (GBS) to develop new geographically informative nuclear SNP markers in Picea abies. This set of 518 loci consists of 397 loci specifically designed for the geographic differentiation of populations and 121 loci of adaptive markers for drought stress which all were identified from 26 samples in 23 populations distributed over Central Europe. This set of novel markers represents a valuable basis to study the geographic population structure and genetic differentiation of Picea abies in its natural distribution range as well as outside of its native range with a focus on Central Europe.
Functional food characteristics in organic food products—the perspectives of Italian consumers on organic eggs enriched with omega-3 polyunsaturated fatty acids
Authors: Migliore G. , Rizzo G. , Bonanno A. , Dudinskaya E. Cubero , Tóth J. , Schifani G. 
Published: May 2022

Abstract
Innovation in organic food products plays an important role in further developing its competitiveness in the market and meeting the emerging consumers’ needs. However, few studies have analysed consumers’ points of view of innovations on organic food, limited to the change in the natural food composition or the enrichment of the nutritional contents of the product. This study, using experimental auctions, aims to overcome this gap by enriching the knowledge on organic consumers’ preference for organic food with functional characteristics. Specifically, this study analyses the willingness to pay (WTP) of 110 Italian consumers for organic eggs enriched with omega-3 polyunsaturated fatty acids (PUFA), compared to standard organic eggs, and the factors underlying this choice. Findings of the study reveal that over 73% of the sample is willing to pay an average price premium of €0.16 for functional organic eggs. This choice is mainly due to both selfish factors and a high attitude towards the environment. From a theoretical perspective, these findings enrich the literature on consumers of organic food with functional characteristics. At the same time, from a managerial point of view these results could be of interest for those breeding of laying hens that want to innovate and be competitive on the market segment of functional food. Finally, this study also contributes to the political discussions regarding the organic agriculture of the future which may also include health claims.
NebulaStream: Data Management for the Internet of Things
Authors: Zeuch Steffen , Chatziliadis Xenofon , Chaudhary Ankit , Giouroukis Dimitrios , Grulich Philipp M. , Nugroho Dwi Prasetyo Adi , Ziehn Ariane , Mark Volker 
Published: May 2022

AbstractThe Internet of Things (IoT) presents a novel computing architecture for data management: a distributed, highly dynamic, and heterogeneous environment of massive scale. Applications for the IoT introduce new challenges for integrating the concepts of fog and cloud computing as well as sensor networks in one unified environment. In this paper, we present early approaches that address parts of the overall problem space. All approaches are incorporated into NebulaStream (NES), our novel data processing platform that addresses the heterogeneity, unreliability, and scalability challenges of the IoT and thus provides efficient data management for future applications.
Prescription-grade crystalline glucosamine sulfate as an add-on therapy to conventional treatments in erosive osteoarthritis of the hand: results from a 6-month observational retrospective study
Authors: Tenti Sara , Veronese Nicola , Cheleschi Sara , Seccafico Iole , Bruyère Olivier , Reginster Jean-Yves , Fioravanti Antonella 
Published: May 2022

Abstract
Objective
To evaluate the efficacy of prescription-grade Crystalline Glucosamine Sulfate (pCGS) as an add-on treatment to conventional therapy, compared to usual therapy alone, in patients with erosive osteoarthritis of the hand (EHOA).

Methods
This 6-month retrospective case–control study included patients with concomitant knee osteoarthritis and symptomatic EHOA. Participants were stratified into two groups based on whether or not pCGS (1500 mg/day) was added to the conventional therapy (education and training in ergonomic principles, exercise and use on-demand of symptomatic drugs) for hand osteoarthritis. Patients were evaluated at baseline, after 3 and 6 months. Primary outcomes were the change from baseline to month 6 in Visual Analogue Scale (VAS) hand pain and in Functional Index for Hand Osteoarthritis (FIHOA) score. A set of secondary parameters was also evaluated.

Results
123 patients were included as follows: 67 treated with pCGS in addition to conventional therapy (pCGS Group) and 56 with conventional therapy alone (Control Group). After 6 months a significant difference in VAS and in FIHOA score (p < 0.01 and p < 0.001, respectively) was observed in favor of pCGS Group. Similar results were found for morning stiffness duration (p < 0.05), health assessment questionnaire (p < 0.01) and physical and mental component score of 36-item short form (p < 0.05 and p < 0.001, respectively). A significant reduction of symptomatic drug consumption at 3 and 6 months was reported in the pCGS Group (p < 0.001). No serious adverse event was recorded in both groups.

Conclusions
Despite all the limitations inherent to an observational study, our results suggest the potential effectiveness of pCGS, when used in combination with conventional therapy in EHOA. Further randomized placebo-controlled trials are needed to confirm these positive findings.

Trial Registration
ClinicalTrials.gov, http://www.clinicaltrials.gov, date of registration: February
2, 2022, NCT05237596. The present trial was retrospectively registered.
Effects of weight loss on bone turnover, inflammatory cytokines, and adipokines in Chinese overweight and obese adults
Authors: Yu D. , Chen W. , Zhang J. , Wei L. , Qin J. , Lei M. , Tang H. , Wang Y. , Xue S. , Dong J. , Chen Y. , Xie L. , Di H. 
Published: May 2022

Abstract
Purpose
Plenty of studies have examined the long term effect of weight loss on bone mineral density. This study aimed to explore the effects of 10% weight loss on early changes in bone metabolism as well as the possible influencing factors.

Methods
Overweight and obese outpatients (BMI > 24.0 kg/m2) were recruited from the nutrition clinic and followed a calorie-restricted, high-protein, low-carbohydrate diet program. Dietary intake, body composition, serum procollagen type I N-propeptide (PINP), β-Crosslaps, PTH, 25(OH) VitD, a series of inflammatory cytokines and adipokines were measured for the participants before starting to lose weight and after 10% weight loss (NCT 04207879).

Results
A total of 75 participants were enrolled and 37 participants achieved a weight loss of at least 10%. It was found that PINP decreased (p = 0.000) and the β-Crosslaps increased (p = 0.035) in female participants. Decreases in PTH (p = 0.001), serum IL-2 (p = 0.013), leptin (p = 0.001) and increases in 25(OH) VitD (p = 0.001), serum ghrelin (p = 0.033) were found in 37 participants after 10% of their weight had been lost. Change in PINP was detected to be significantly associated with change in lean body mass (r = 0.418, p = 0.012) and change in serum ghrelin(r = − 0.374, p = 0.023).

Conclusions
Bone formation was suppressed and bone absorption was increased in female subjects after a 10% weight loss. Bone turnover was found to be associated with lean body mass and affected by the circulating ghrelin level.
Distributed neurodynamic approaches to nonsmooth optimization problems with inequality and set constraints
Authors: Luan Linhua , Wen Xingnan , Qin Sitian 
Published: May 2022

AbstractIn this paper, neurodynamic approaches are proposed for solving nonsmooth distributed optimization problems under inequality and set constraints, that is to find the solution that minimizes the sum of local cost functions. A continuous-time neurodynamic approach is designed and its state solution exists globally and converges to an optimal solution of the corresponding distributed optimization problem. Then, a neurodynamic approach with event-triggered mechanism is considered for the purpose of saving communication costs, and then, the convergence and its Zeno-free property are proved. Moreover, to realize the practical application of the neurodynamic approach, a discrete-time neurodynamic approach is proposed to solve nonsmooth distributed optimization problems under inequality and set constraints. It is rigorously proved that the iterative sequence generated by the discrete-time neurodynamic approach converges to the optimal solution set of the distributed optimization problem. Finally, numerical examples are solved to demonstrate the effectiveness of the proposed neurodynamic approaches, and the neurodynamic approach is further applied to solve the ill-conditioned Least Absolute Deviation problem and the load sharing optimization problem.
The world of inorganic pigments
Authors: Pfaff Gerhard 
Published: May 2022

Abstract
Inorganic pigments have been very important substances for human life for thousands of years. They have contributed and continue to contribute to the beautification of our daily life and habitat and to the accentuation and differentiation of objects, and influence thoughts, moods, and feelings. The industrial manufacture of inorganic pigments based on growing chemical and physical knowledge started around 1800. Before that, pigments based on natural materials or manufactured by mostly empirical processes were used. Most of the technically relevant inorganic pigments were developed and first produced on an industrial scale in the nineteenth and twentieth centuries. Ongoing developments are aiming to improve existing conventional pigments as well as synthesize new, innovative colorants, especially in the classes of effect pigments and functional pigments. The objective of this text is to present comprehensive knowledge about inorganic pigments, including definitions, types of pigments and their properties, historical pigments, modern inorganic pigments, synthesis methods, and applications. It is also intended to show the current status of new pigment developments.

Graphical abstract
Collection of samples of inorganic pigments
Evaluating a Two-Tiered Parent Coaching Intervention for Young Autistic Children Using the Early Start Denver Model
Authors: van Noorden Lauren E. , Sigafoos Jeff , Waddington Hannah L. 
Published: May 2022

Abstract

Objectives
Early intervention can improve the outcomes of young autistic children, and parents may be well placed to deliver these interventions. The Early Start Denver Model (ESDM) is a naturalistic developmental behavioral intervention that can be implemented by parents with their own children (P-ESDM). This study evaluated a two-tiered P-ESDM intervention that used a group parent coaching program, and a 1:1 parent coaching program. We evaluated changes in parent use of the ESDM and parent stress, as well as child engagement, communication, and imitation.

Methods
Seven autistic or probably autistic children (< 60 months old) and their parents participated. A multiple-baseline design was used to compare individual changes between Baseline 1, Group Coaching (Tier 1), Baseline 2, and 1:1 Coaching (Tier 2). Parent and child behaviors were analyzed from weekly videos and graphed. Parenting stress was measured.

Results
All parents improved in their use of ESDM strategies after the Tier 1 intervention. Changes in parent fidelity during Tier 2 were mixed, but all parents maintained higher than baseline levels of fidelity. Six parents demonstrated above 75% ESDM fidelity in at least one session. There were positive changes in parent stress levels pre- post-intervention. Positive results were found for most children’s levels of engagement, imitation, and communication. There were significant positive relationships between parent fidelity and both child engagement and child functional utterances.

Conclusions
Group P-ESDM is a promising approach for improving parent fidelity and some child outcomes. Future randomized and controlled studies of group P-ESDM, using standardized outcome measures, are warranted.
COVID-19 and distortions in urban food market in India
Authors: Rajkhowa Pallavi , Kornher Lukas 
Published: May 2022

AbstractIn this paper, we study the effects of the spread of COVID-19 on retail and wholesale prices of urban markets in India, as well as price distortion between markets and the mark-up between retail and wholesale prices. Using fixed-effects panel regression models, we find that with the spread of COVID-19, prices increased for commodities with longer shelf-life such as pulses and processed items, while prices of vegetables such as onions and tomatoes declined substantially at the onset of the pandemic. Further, market distortions increased significantly for most commodities. Pulses experienced large price distortions between markets as well as mark-ups between retail and wholesale prices. We, however, do not see any major price distortions in the market for rice and wheat, which are controlled by Government’s minimum support prices.