bluuebunny/crossref_metadata_2025_split huggingface dataset:
Genetic mapping and selection of table grape fruit quality characteristics in a segregating population and evaluation of marker transferability
Authors: Moreira Laise de Sousa , Tabb Amy , Karn Avi , Zou Cheng , DeLong Jeff , Burhans Alanna , Yang Hui-Ching , Zyl Sonet van , Prins Bernard , Sun Qi , Londo Jason , Clark Matt , Naegele Rachel 
Published: October 2022

Abstract
Grape production and fruit quality traits such as cluster size, berry shape, and timing of fruit development are key aspects in selecting cultivars for commercial production. Molecular markers for some, but not all, of these traits have been identified using bi-parental or association mapping populations. Previously identified markers were tested for transferability using a test panel of commercially available grape cultivars. Markers had little to no ability to differentiate grape phenotypes based on the expected characteristics, except the marker for seedlessness. Using a biparental inter-specific cross, forty-three QTL, both previously identified and new genomic regions, associated with berry shape, number, size, cluster weight, length, and time to flower, veraison and full color were detected. KASP markers designed on newly identified QTL were tested for transferability using the same panel. Transferability was low when use types were combined, but varied when use type were evaluated separately. Comparison of a 4Mb region at the end of chromosome 18 revealed structural differences among grape species and use types. Table grape cultivars had the highest similarity in structure for this region (> 75%) compared to other grape species and commodity types.
On the Tribo-dynamics of Lubricated Point Contacts – Modeling and Experiment
Authors: Li Sheng , Kolivand Ali , Shi Zhenghong , Anisetti Anusha 
Published: October 2022

Abstract
This study proposes a modeling methodology for the description of tribo-dynamic behavior of generic point contacts, considering surface defect/failure type of excitation. A twin-disk contact setup is developed to experimentally determine the acceleration induced by lab-controlled groove surface feature present on one of the mating surfaces. The periodic passage of this artificial surface defect through lubricated contact zone leads to contact force fluctuation, and consequently normal direction dynamic relative displacement and relative velocity of the contact bodies. These dynamic responses impact the lubrication film thickness and flow, altering the tribological performance that governs the contact force. Implementing this interaction loop between dynamics and tribology, the computational simulations are shown to be able to yield fairly accurate predictions in comparison to the measured acceleration signals.
Left coronary sinus of Valsalva aneurysm dissecting into interventricular septum: a case report
Authors: Zhang Lei , Ji Donghui , Li Xiaoyun 
Published: October 2022

Abstract
Sinus of Valsalva aneurysm is extremely rare. The ruptured sinus of Valsalva aneurysm is frequently associated with other congenital defects. If the aneurysm ruptures, it causes acute symptoms of dyspnea. We describe a case of a sinus Valsalva aneurysm originating from the left coronary sinus that ruptured into the interventricular septum, diagnosed with echocardiography and cardiac computed tomography, confirmed by operational findings.
Mangement of hypogammaglobulinemia in pediatric patients with refractory lupus nephritis: Focus on belimumab
Authors: Cui jieyuan , Li chunzhen , Yuan xiaoying , Han Peitong , Zhang Dongfeng , Zhang Lei 
Published: October 2022

Abstract
Background: Although the use of belimumab in children with lupus nephritis has increased over the past few years, there are limited data on the safety of belimumab in such patients with hypogammaglobulinemia. There are few reports of an association between hypogammaglobulinemia and infection in LN patients receiving belimumab treatment.
Methods: We reviewed 27 patients with lupus nephritis and nephrotic-range proteinuria admitted to Hebei Children's Hospital from January 2019 to June 2022. In all 27 patients, 12 received intravenous (IV) belimumab (at a dose of 10 mg per kilogram of body weight) plus standard systemic lupus erythematosus (SLE) therapy (SoC) (belimumab group), and the other 15 received SoC (glucocorticoids plus cyclophosphamide or mycophenolate mofetil) (control group). Estimated SLEDAI-score, total amount of urine protein in 24 hours, the serum level of IgG, IgM, IgA and C3, total B lymphocyte count (BLC) , total white lymphocyte count (WBC), erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) level were measured 5 times (at week 0, 4, 12, 24 and 52, respectively) in two groups.
Results: Hypogammaglobulinemia was observed in 22/27 (81.5%) participants prior to initiatial treatment of LN patients with nephrotic range proteinuria. Participants developed hypogammaglobulinemia by week 4, 5 patients in the belimumab group and 1 patient in control group received 1-2 IVIG treatments at weeks 16-26 due to severe or recurrent infections. The incidence of infection was significantly higher in patients in the belimumab group than in the control group, and the IVIG serum level was significantly lower than the control group. However, infection rates and serum IgG levels were not significantly different between the two groups at weeks 24 and 52. We also found that CRP level of patients in the belimumab group was significantly lower than in the control group at week 4 and week 24 respectively (P<0.05), and ESR level of patients in the belimumab group was also significantly lower than in the control group at week 12 (P<0.05). At week 52, WBC of patients in the belimumab group was significantly higher than in the control group(P<0.05).
Conclusions: Hypogammaglobulinemia is a complication of refractory LN，obtaining IgG level before initiating belimumab in pediatric patients with refractory lupus nephritis，and close monitoring of hypogammaglobulinemia after belimumab use in pediatric patients. Immunoglobulin replacement therapy should be initiated as soon as possible if patients develop recurrent infections.
Experimental study on longitudinal-torsional ultrasonic vibration drilling of carbon fiber reinforced plastics/titanium alloy stacks
Authors: Zhou Zhiyuan , Yong Feng , Xu Weiwei , Zhou Haojie , Qin Yuyan , Jia Xiaolin 
Published: October 2022

Abstract
Carbon fiber reinforced plastics (CFRP)/Titanium alloy (Ti) stacks are being extensively applied in the aerospace industry for excellent mechanical properties. However, their poor machinability poses great challenges to the aircraft manufacturing industry. In this study, longitudinal-torsional ultrasonic vibration drilling (LT-UVD) is innovatively introduced to improve the quality of CFRP/Ti drilling. First, the separation mode of LT-UVD was analyzed by kinematic equation. Then, an experimental platform was built based on LT-UVD vibration actuator to carry out CFRP/Ti drilling experiments. The thrust force, interface temperature, hole wall quality, hole defects, Ti chip morphologies and tool wear in conventional drilling (CD), Longitudinal ultrasonic vibration drilling (L-UVD), and LT-UVD were compared in the experiment. The experimental results show that compared with CD and L-UVD, the thrust force of CFRP in LT-UVD decreases by 20.36%-40.55% and 2.04%-14.61%, and the thrust force of Ti decreases by 19.08%-24.83% and 1.95%-9.34%. At the same time, a relatively low maximum interface temperature is achieved in LT-UVD. In addition, the hole size accuracy, surface roughness for hole inner surface, and delamination factor are improved in LT-UVD. Due to the existence of torsional vibration in LT-UVD, the cavity and fiber pull-out defects, chip breaking performance, and tool wear of CFRP are improved. Finally, it is observed by high-speed camera that the damage forms of the interface area are different when drilling CFRP/Ti stacks with different drilling sequence.
Vascular comorbidity is associated with decreased cognitive functioning in inflammatory bowel disease
Authors: Patel Ronak , Marrie Ruth Ann , Bernstein Charles N , Bolton James M , Graff Lesley A. , Marriott James J , Figley Chase R , Kornelsen Jennifer , Mazerolle Erin L , Uddin Md Nasir , Fisk John D. 
Published: October 2022

Abstract
Background: Reports of cognitive impairment in inflammatory bowel disease (IBD) have been mixed. IBD and cardiovascular disease are often co-morbid, yet it remains unknown whether vascular comorbidity confers a risk for decreased cognitive functioning, as observed in other populations.
Methods: Participants with IBD were recruited from a longitudinal study of immune-mediated disease. Participants were administered a standardized neuropsychological test protocol, evaluating information processing speed, verbal learning and memory, visual learning and memory, and verbal fluency/executive function. Cognitive test scores were standardized using local regression-based norms, adjusting for age, sex, and education. Vascular risk was calculated using a modified Framingham Risk Score (FRS). We tested the association between FRS and cognitive test scores using a quantile regression model, adjusting for IBD type.
Results: Of 84 IBD participants, 54 had ulcerative colitis and 30 had Crohn’s disease; mean (SD) age was 53.36 (13.95) years, and a high proportion were females (n = 58). As the risk score (FRS) increased, participants demonstrated lower performance in information processing speed (β=-0.12; 95% CI: -0.24, -0.006) and verbal learning (β=-0.14; 95% CI: -0.28, -0.01) at the 50th percentile. After adjusting for IBD type, higher FRS remained associated with lower information processing speed (β=-0.13; 95% CI: -0.24, -0.03).
Conclusion: Vascular comorbidity is associated with lower cognitive functioning in persons with IBD, particularly in the areas of information processing speed and verbal learning. These findings suggest that prevention, identification, and treatment of vascular comorbidity in IBD may play a critical role for improving functional outcomes in IBD.
A prediction method for influenza during COVID-19 in Shanxi Province, China: LSTM-SARIMA hybrid model based on Singular Spectrum Analysis
Authors: Zhao Zhiyang , Zhai Mengmeng , Li Guohua , Gao Xuefen , Wang Xuchun , Ren Hao , Cui Yu , Qiao Yuchao , Ren Jiahui , Chen Limin , Qiu Lixia 
Published: October 2022

Abstract
To handle the difficulties of modeling and prediction caused by the abnormal influenza sequence during COVID-19, this study established a hybrid prediction model of Long-Short Term Memory neural network (LSTM) and seasonal autoregressive integrated moving average (SARIMA) based on Singular spectrum analysis (SSA), which provided an effective scientific basis for the high-precision prediction of influenza in Shanxi Province during the COVID-19. Seasonal-trend decomposition using Loess (STL) was adopted to analyze the season characteristics of the ratio of weekly influenza-like illness (ILI) patients in Shanxi Province, China, from the 14th week in 2010 to the 13th week in 2021. The SARIMA model, the LSTM model and the LSTM-SARIMA hybrid model based on SSA were established to predict the influenza in Shanxi Province during the COVID-19. Mean Absolute Error (MAE) and Mean Absolute Percentage Error (MAPE) were used to evaluate the performance of the models. Affected by the COVID-19, the influenza time sequence in Shanxi Province has been complicated since the beginning of 2020, with the peak incidence much lower than before. Compared with those of the SARIMA model, the MAE and MAPE of the LSTM-SARIMA hybrid model based on SSA decreased by 28.9 and 32.2%, respectively, in fitting performance; in terms of prediction performances, the MAE and MAPE decreased by 52.5 and 52.1%, respectively. Compared with those of the LSTM model, the MAE and MAPE of the LSTM-SARIMA hybrid model based on SSA decreased by 26.2 and 27.5%, respectively, in fitting performance; in terms of prediction performances, the MAE and MAPE decreased by 35.0 and 35.3%, respectively. The fitting and prediction performances of the LSTM-SARIMA hybrid model based on SSA were better than those of the SARIMA and the LSTM models. Generally speaking, we can apply the LSTM-SARIMA hybrid model based on SSA to the prediction of influenza during the COVID-19, and offer a leg-up for public policy.
Family UNited: Piloting of a new universal UNODC family skills programme to improve child mental health, resilience and parenting skills in Indonesia and Bangladesh
Authors: Haar Karin , El-Khani Aala , Narotama Narendra , Hussain Amir , Fitri Eva , Badrujaman Aip , Wahyuni Eka , Naheeaan Shah Mohammad , Yassine Ali , Maalouf Wadih 
Published: October 2022

Abstract
Background
Family is one of the most influential social institutions and caregivers act as the main protective factors for children’s mental health and resilience skills. Family skills programmes support caregivers to be better parents and strengthen positive age-specific and age-appropriate family functioning and interactions. We developed a universal, brief and light programme for implementation in low-resource settings; the Family UNited (FU) programme and conducted a pilot study to show feasibility of implementation, replicability and effectiveness in improving family functioning, child behaviour and resilience.
Methods
We recruited caregivers with children aged 8-14 years through schools in East Java, Indonesia and Dhaka, Bangladesh to the FU programme. Demographic data, emotional and behavioural difficulties of children, child resilience and parental skills and family adjustment measures were collected from children and caregivers before, 2 and 6 weeks after the intervention. Outcome was assessed through the SDQ (Strengths and Difficulties Questionnaire), PAFAS (Parenting and Family Adjustment Scales) and CYRM-R (Child and Youth Resilience Measure).
Results
We enrolled 29 families in Bangladesh and allocated 37 families to the intervention and 33 to the control group in Indonesia. Overall, there was no effect over time in the control group on any of the PAFAS subscales, whereas significant reductions in scores were found on six of the seven subscales in either country in the intervention group, most prominently in caregivers with higher scores at baseline. We found highly significant reductions in total SDQ scores in the intervention group in both countries, whereas there was no effect over time in the control group in Indonesia. Boys in the intervention group in Indonesia and in Bangladesh seemed to have benefitted significantly on the SDQ as well as the total resilience scale. Overall, on the CYRM-R, particularly children below the 33rd percentile at pre-test benefitted substantially from the programme.
Conclusions
The implementation of a brief family skills programme was seemingly effective and feasible in resource-limited settings and positively improved child mental health, resilience and parenting practices and family adjustment skills. These results suggest the value of such a programme and call for further validation through other methods of impact assessment and outcome evaluation.
Trial registration
Clinical Trial Registration: ISRCTN (number pending payment, technically approved), retrospectively registered, 22 September, 2022.
Quantum spin Hall states and topological phase transition in germanene
Authors: Bampoulis Pantelis , Castenmiller Carolien , Klaassen Dennis , Mil Jelle van , Liu Yichen , Liu Cheng-cheng , Yao Yugui , Ezawa Motohiko , Rudenko Alexander , Zandvliet Harold 
Published: October 2022

Abstract
The realization of the topological field-effect transistor requires an electric field-induced transition from a topological state with dissipationless conductive channels (`On') to a trivial insulator state (`Off'). Monoelemental and buckled quantum spin Hall insulators with large topological band gaps are ideal candidates to investigate topological phase transitions. We provide compelling experimental evidence that low-buckled epitaxial germanene is a quantum spin Hall insulator with a large bulk gap and robust metallic edge states. The low-buckled structure of germanene allows for topological phase transitions to take place. Upon the application of a critical transversal electric field, the topological gap closes and germanene becomes a Dirac semimetal. Increasing the electric field further results in opening of a trivial gap and disappearance of the edge states. This reversible electric field-induced switching of the topological state and the sizeable gap make germanene suitable for room-temperature topological field-effect transistors, which could revolutionize low-energy electronics and spintronics.
Ultrasonographic assessment of diaphragmatic function in preterm infants on Non-Invasive Neurally Adjusted Ventilatory Assist (NIV-NAVA) compared to Nasal Intermittent Positive-Pressure Ventilation (NIPPV): A prospective observational study
Authors: Elkhouli Mohamed , Tamir-Hostovsky Liran , BSc Jenna Ibrahim , Nasef Nehad , Mohamed Adel 
Published: October 2022

Abstract
Purpose of the study: NIV-NAVA mode for respiratory support in preterm infants is not well-studied. The aim of this study was to describe diaphragmatic function, diaphragmatic excursion (DE) and thickness fraction (DTF), in preterm infants < 30 weeks’ gestation supported by NIV-NAVA compared to NIPPV using bedside ultrasonography.
Methods: In this consecutive prospective study, DE, diaphragmatic thickness at end of expiration (DTexp), end of inspiration (DTins), and DTF were assessed using bedside ultrasound. Lung aeration evaluation using lung ultrasound score (LUSs) was performed for the two groups. Diaphragmatic measurements and LUSs were compared for the 2 groups (NIV-NAVA group versus NIPPV group). Statistical analyses were conducted using SPSS software version 22.
Results: Out of 70 infants evaluated, 40 were enrolled. Twenty infants were on NIV-NAVA (mean [SD] study age of 25.7 [0.9] weeks) and 20 infants were on NIPPV (mean [SD] study age of 25.1 [1.4] weeks p= 0.15). Baseline characteristics and respiratory parameters at the time of the scan, showed no significant difference between groups. DE was significantly higher in NIV-NAVA with a mean SD 4.7 (1.5) versus 3.5 (0.9) in NIPPV, p=0.007. Additionally, the mean (SD) of DTF for the NIV-NAVA group was 81.6 (30) vs 78.2 (27) for NIPPV group [p=0.71]. Both groups showed relatively high LUSs but no significant difference between groups [12.8 (2.6) vs 12.6 (2.6) p=0.8].
Conclusion: Preterm infants managed with NIV-NAVA showed significantly higher DE compared to those managed on NIPPV. Longitudinal studies to assess diaphragmatic function over time are needed.
Trial Registry: Clinicaltrials.gov (NCT05079412)
Date of registration 09/30/2021
Abstract publication/presentation: Portions of this paper were presented at the Pediatric Academic Society (PAS) meeting in Denver, USA, May 2022 as poster presentation as well as at the 4th Neonatal Research Day- Toronto, Canada on April, 2022 as an oral presentation.
Bidirectional Formation-involved Consensus for Uncertain Multi-Lagrange Systems under Directed Signed Topology Networks
Authors: Ma Xinru , Liu Jingyi , Li Hengyu , Xie Yonghao , Zhang Tiehui , Wang Zhaoyan , Wang Yueying , Liu Jun , Xie Shaorong , Luo Jun 
Published: October 2022

Abstract
To better describe the complex behaviors of multi-agent systems (MAS), this paper proposes a bidirectional formation-involved (FI) consensus control method for multi-Lagrange systems (MLS). It primarily considers the Lagrange systems with uncertain parameters and employs the bipartite topology in communication network. Under bidirectional formation control, the validity of this control protocol and the stability of the MLS are verified, by determining the consistency convergence of the Lyapunov function of the systems. For the given stabilized MLS, the leader is added with first-order linear system to provide trajectory guidance. With cooperative-competitive interactions, MLS perform the FI complex behavior considering trajectory tracking. The experiment part provides sufficient simulation examples that are selected to be consistent with the systems in the theoretical part.
Development and Validation of a Stability Indicating RP-HPLC Method of a Synthetic Thiophene Chalcone and its degradation products
Authors: Raheja Radhika , Pise Nikita , Prabhu Arati 
Published: October 2022

Abstract
The current paper describes a simple accurate, precise, and robust reversed-phase high-performance liquid chromatographic-stability-indicating assay method using isocratic elution for quantitative estimation of a 1-(4-benzyloxy)phenyl-3-(2-thienyl)prop-2-en-1-one; a benzyl thiophene chalcone (TC) synthesized in our laboratory for anti-Alzheimer’s activity and its degradation products obtained from forced degradation studies. The method was developed using Thermo Scientific C18 column (250 x 4.6 mm, 5 µm) as stationary phase and sodium acetate buffer (pH 3.0): acetonitrile (40:60, v/v) as the mobile phase at 1 ml/min flow rate and 280 nm as detection wavelength. TC eluted at a retention time of 27.4 min. The method was validated as per ICH guidelines. Linearity was obtained in the range of 5–15 µg/ml, the limit of detection was found to be 0.323 µg/ml and the limit of quantification was found to be 0.978 µg/ml. Inter-day and intra-day precision was 0.59% and 0.90% respectively. TC was subjected to forced degradation studies in basic, acidic, oxidative, thermal, photolytic, and thermal humidity stress conditions in accordance with ICH guidelines. It was found to be stable under thermal and thermal-humidity stress but degraded to different extents under acidic and basic hydrolytic conditions, oxidative stress, and photolytic conditions.
Analysis of characteristics and prognostic factors among young patients with lung cancer
Authors: Li Mengqi , Yang Hao , Mu Junhao , Li Weiyi , Yang Li , Mei Tonghua 
Published: October 2022

Abstract
Purpose
To assess characteristics and prognostic factors among 18–40-year-old patients with lung cancer.
Methods
A retrospective analysis was performed using clinical data of 18–40-year-old patients diagnosed with primary lung cancer in the Department of Respiratory and Critical Care Medicine and Department of Thoracic Surgery of the First Affiliated Hospital of Chongqing Medical University from 1 January 2015 to 1 January 2021. The patients’ characteristics and prognostic risk factors were analysed.
Results
This study included 284 patients (74 males and 210 females). Their median age was 36 years. In total, 77.11% of patients were asymptomatic at initial diagnosis. Moreover, 14.08%, 3.87% and 10.21% of patients had a smoking history, personal tumour history and family tumour history, respectively. Furthermore, 59.86% of the lesions were located on the right side, 58.10% were located in the upper lobe, 88.03% were sized ≤ 3 cm, 93.31% were adenocarcinomas, 84.51% were TNM stage 0-I and 90.85% required surgical treatment. Significant differences in smoking history, cough and expectoration, tumour density, tumour size, pathological type, disease stage and treatment modalities were noted between men and women. Multivariate analysis revealed that smoking history, disease stage, surgical treatment and targeted therapy were independent prognostic factors for overall survival.
Conclusion
The onset of lung cancer in 18–40-year-old people was insidious, and the symptoms were atypical, mainly in patients with early adenocarcinoma. Surgical treatment and targeted therapy were factors improving prognosis. Early diagnosis and treatment are thus crucial for improving the prognosis of young patients with lung cancer.