bluuebunny/crossref_metadata_2025_split huggingface dataset:
What do I want to feel? Emotion goals in childhood, adolescence, and adulthood
Authors: López‐Pérez Belén , Gummerum Michaela , Jiménez Marcos , Tamir Maya 
Published: September 2022

AbstractBeliefs about emotion utility can influence context‐sensitive emotion goals (i.e., desired emotional responses). Although key for emotion regulation, emotion goals have been overlooked in children and adolescents. In 2018–2019 results of Studies 1 and 2 showed that children (N = 192, Mage = 8.65, 47% girls, 96% White) were less motivated by and found anger less useful in confrontation than adolescents (N = 192, Mage = 12.96, 50% girls, 93% White) and adults (N = 195, Mage = 29.82, 51% women, 96% White). The link between emotion goals and beliefs about emotion utility was weaker in children. In 2021, Study 3 (N = 60, 8‐year‐olds, 47% girls, 90% White) ruled out expectations as a possible explanation for the previous findings. Context‐sensitive utility of emotions may be acquired during development.
Evocube: A Genetic Labelling Framework for Polycube‐Maps
Authors: Dumery C. , Protais F. , Mestrallet S. , Bourcier C. , Ledoux F. 
Published: September 2022

AbstractPolycube‐maps are used as base‐complexes in various fields of computational geometry, including the generation of regular all‐hexahedral meshes free of internal singularities. However, the strict alignment constraints behind polycube‐based methods make their computation challenging for CAD models used in numerical simulation via finite element method (FEM). We propose a novel approach based on an evolutionary algorithm to robustly compute polycube‐maps in this context.We address the labelling problem, which aims to precompute polycube alignment by assigning one of the base axes to each boundary face on the input. Previous research has described ways to initialize and improve a labelling via greedy local fixes. However, such algorithms lack robustness and often converge to inaccurate solutions for complex geometries. Our proposed framework alleviates this issue by embedding labelling operations in an evolutionary heuristic, defining fitness, crossover, and mutations in the context of labelling optimization. We evaluate our method on a thousand smooth and CAD meshes, showing Evocube converges to accurate labellings on a wide range of shapes. The limitations of our method are also discussed thoroughly.
Effect of neurofilament analysis on the diagnostic delay in amyotrophic lateral sclerosis
Authors: De Schaepdryver Maxim , Masrori Pegah , Van Damme Philip , Poesen Koen 
Published: September 2022

AbstractAimsThe aim of this study was to investigate whether neurofilament light (NfL) and phosphorylated neurofilament heavy (pNfH) in cerebrospinal fluid (CSF), sampled prior to referral to a neuromuscular reference center (NMRC), shorten the diagnostic delay in patients with amyotrophic lateral sclerosis.MethodsIn this retrospective study, patients with ALS were included with (i) determination of neurofilaments (Nfs) before referral to the NMRC (preC‐Nfs ALS, n = 58), (ii) determination of Nfs at the NMRC (C‐Nfs, n = 54) or (iii) with no determination of Nfs (C‐No Nfs, n = 180). Fifty‐six disease controls were included.ResultsThe preC‐Nfs cohort had CSF sampled 2.2 months (range: 0.6–12.0 months) before referral to the NMRC. In this cohort, the diagnostic delay was significantly shorter [median (range): 8.24 (2.37–49.7) months] than in the C‐Nfs cases [median (range): 11.4 (2.93–86.5) months; p < 0.05], but not in the C‐No Nfs cases. When including the disease progression rate and the presence of a genetic mutation as covariates, the difference ceased to exist (p = 0.14). pNfH and NfL levels in the preC‐Nfs cohort were significantly higher than in disease controls (p < 0.0001). Both Nfs showed a similar discriminating performance.ConclusionsCSF Nfs assessed before the diagnosis of ALS at a NMRC decreased the diagnostic delay in specific cases by 3 months and only when other covariates were not taken into account.
Evidence‐based guidelines for automated conservation assessments of plant species
Authors: Walker Barnaby E. , Leão Tarciso C. C. , Bachman Steven P. , Lucas Eve , Nic Lughadha Eimear 
Published: September 2022

AbstractAssessing species’ extinction risk is vital to setting conservation priorities. However, assessment endeavors, such as those used to produce the IUCN Red List of Threatened Species, have significant gaps in taxonomic coverage. Automated assessment (AA) methods are gaining popularity to fill these gaps. Choices made in developing, using, and reporting results of AA methods could hinder their successful adoption or lead to poor allocation of conservation resources. We explored how choice of data cleaning type and level, taxonomic group, training sample, and automation method affect performance of threat status predictions for plant species. We used occurrences from the Global Biodiversity Information Facility (GBIF) to generate assessments for species in 3 taxonomic groups based on 6 different occurrence‐based AA methods. We measured each method's performance and coverage following increasingly stringent occurrence cleaning. Automatically cleaned data from GBIF performed comparably to occurrence records cleaned manually by experts. However, all types of data cleaning limited the coverage of AAs. Overall, machine‐learning‐based methods performed well across taxa, even with minimal data cleaning. Results suggest a machine‐learning‐based method applied to minimally cleaned data offers the best compromise between performance and species coverage. However, optimal data cleaning, training sample, and automation methods depend on the study group, intended applications, and expertise.
A roadmap for the conservation of freshwater mussels in Europe
Authors: Sousa Ronaldo , Zając Tadeusz , Halabowski Dariusz , Aksenova Olga V. , Bespalaya Yulia V. , Carvalho Francisco , Castro Paulo , Douda Karel , da Silva Janine P. , Ferreira‐Rodríguez Noé , Geist Juergen , Gumpinger Clemens , Labecka Anna M. , Lajtner Jasna , Lewin Iga , Lopes‐Lima Manuel , Meira Alexandra , Nakamura Keiko , Nogueira Joana Garrido , Ondina Paz , Ożgo Małgorzata , Reis Joaquim , Riccardi Nicoletta , Shumka Spase , Son Mikhail O. , Teixeira Amílcar , Thielen Frankie , Urbańska Maria , Varandas Simone , Wengström Niklas , Zając Katarzyna , Zieritz Alexandra , Aldridge David C. 
Published: September 2022

AbstractEurope has a long history of human pressure on freshwater ecosystems. As pressure continues to grow and new threats emerge, there is an urgent need for conservation of freshwater biodiversity and its ecosystem services. However, whilst some taxonomic groups, mainly vertebrates, have received a disproportionate amount of attention and funds, other groups remain largely off the public and scientific radar. Freshwater mussels (Bivalvia, Unionida) are an alarming example of this conservation bias and here we point out six conceptual areas that need immediate and long‐term attention: knowledge, threats, socioeconomics, conservation, governance and education. The proposed roadmap aims to advance research, policy and education by identifying the most pressing priorities for the short‐ and long‐term conservation of freshwater mussels across Europe.
Alternative corporate governance: Does tax enforcement improve the performance of mergers and acquisitions in China?
Authors: Zhang Liguang , Peng Liao , Fu Xinhong , Zhang Zhe , Wang Yunchen 
Published: September 2022

AbstractResearch Question/IssueWe study whether tax enforcement can function as a corporate governance mechanism in emerging countries with weak tax enforcement. In the case of China, we examine whether and how external monitoring by tax authorities constrains insiders' opportunistic behavior in corporate mergers and acquisitions (M&As).Research Findings/InsightsWe employ the implementation of the third stage of the China Tax Administration Information System (CTAIS‐3) as a quasi‐natural experiment and adopt a difference‐in‐differences (DID) approach. We find that strengthening tax enforcement by CTAIS‐3 can improve the efficiency of M&As by reducing agency problems in the decision‐making process. Our conclusions remain unchanged under a series of robustness checks. Moreover, the results show that the impact is mainly observed in regions with stronger local government taxation motivation and in firms with poorer internal or external governance and poorer accounting information.Theoretical/Academic ImplicationsWe find that strengthening tax enforcement can improve M&A decisions even in emerging markets, which provides direct evidence for the predictions from theory that tax authorities play a governance role in supervising corporate insiders. Our paper also extends the literature on the determinants of M&A performance from the perspective of tax authorities.Practitioner/Policy ImplicationsThis study has policy implications for governments around the world to improve corporate governance by strengthening tax enforcement. The Chinese government applying advanced information technology to tax enforcement can provide a reference for other countries.
Regulatory variants in a novel distal enhancer regulate the expression of CYP3A4 and CYP3A5
Authors: Collins Joseph M. , Nworu Adaeze C. , Mohammad Somayya J. , Li Liang , Li Chengcheng , Li Chuanjiang , Schwendeman Ethan , Cefalu Mattew , Abdel‐Rasoul Mahmoud , Sun Jessie W. , Smith Sakima A. , Wang Danxin 
Published: September 2022

AbstractThe cytochrome P450 3As (CYP3As) are abundantly expressed in the liver and metabolize many commonly prescribed medications. Their expression is highly variable between individuals with little known genetic cause. Despite extensive investigation, cis‐acting genetic elements that control the expression of the CYP3As remain uncharacterized. Using chromatin conformation capture (4C assays), we detected reciprocal interaction between a distal regulatory region (DRR) and the CYP3A4 promoter. The DRR colocalizes with a variety of enhancer marks and was found to promote transcription in reporter assays. CRISPR‐mediated deletion of the DRR decreased expression of CYP3A4, CYP3A5, and CYP3A7, supporting its role as a shared enhancer regulating the expression of three CYP3A genes. Using reporter gene assays, we identified two single‐nucleotide polymorphisms (rs115025140 and rs776744/rs776742) that increased DRR‐driven luciferase reporter expression. In a liver cohort (n = 246), rs115025140 was associated with increased expression of CYP3A4 mRNA (1.8‐fold) and protein (1.6‐fold) and rs776744/rs776742 was associated with 1.39‐fold increased expression of CYP3A5 mRNA. The rs115025140 is unique to the African population and in a clinical cohort of African Americans taking statins for lipid control rs115025140 carriers showed a trend toward reduced statin‐mediated lipid reduction. In addition, using a published cohort of Chinese patients who underwent renal transplantation taking tacrolimus, rs776744/rs776742 carriers were associated with reduced tacrolimus concentration after adjusting for CYP3A5*3. Our results elucidate a complex regulatory network controlling expression of three CYP3A genes and identify two novel regulatory variants with potential clinical relevance for predicting CYP3A4 and CYP3A5 expression.
Teleintervention for users of augmentative and alternative communication devices: A systematic review
Authors: Bekteshi Saranda , Konings Marco , Karlsson Petra , Criekinge Tamaya Van , Dan Bernard , Monbaliu Elegast 
Published: September 2022

AimTo synthesize existing evidence on the effectiveness of speech‐language teleinterventions delivered via videoconferencing to users of augmentative and alternative communication (AAC) devices.MethodA systematic literature search was conducted in 10 electronic databases, from inception until August 2021. Included were speech‐language teleinterventions delivered by researchers and/or clinicians via videoconferencing to users of AAC devices, without restrictions on chronological age and clinical diagnosis. The quality of the studies included in the review was appraised using the Downs and Black checklist and the Single‐Case Experimental Design Scale; risk of bias was assessed using the Risk Of Bias In Non‐Randomized Studies ‐ of Interventions and the single‐case design risk of bias tools.ResultsSix teleinterventions including 25 participants with a variety of conditions, such as Down syndrome, autism, Rett syndrome, and amyotrophic lateral sclerosis met the inclusion criteria. Five studies used a single‐case experimental design and one was a cohort study. Teleinterventions included active consultation (n = 2), functional communication training (n = 2), brain–computer interface (n = 1), and both teleintervention and in‐person intervention (n = 1). All teleinterventions reported an increase in participants’ independent use of AAC devices during the training sessions compared to baseline, as well as an overall high satisfaction and treatment acceptability.InterpretationSpeech‐language teleinterventions for users of AAC devices show great potential for a successful method of service delivery. Future telehealth studies with larger sample sizes and more robust methodology are strongly encouraged to allow the generalization of results across different populations.What this paper adds

Individuals can learn to use augmentative and alternative communication (AAC) devices independently during tele‐AAC interventions.
Service providers and recipients reported an overall high satisfaction and acceptability for AAC services delivered via teleinterventions.
Speech‐language teleinterventions may be an effective method of providing AAC intervention services.
Missed antenatal diabetes care appointments and neonatal outcomes for pregnancies with Type 1 and Type 2 diabetes
Authors: Stafl Lenka , Benham Jamie L. , Frehlich Levi , Donovan Lois E. , Yamamoto Jennifer M. 
Published: September 2022

AbstractBackgroundThere is limited information regarding the association between missed appointments and neonatal outcomes for diabetes in pregnancy.Study MethodsThis retrospective live birth cohort included pregnant women with Type 1 or 2 diabetes who attended specialized clinics from 2008 to 2020. The association between at least one missed antenatal diabetes appointments and outcomes were assessed using logistic regression and reported as adjusted odds ratios (aOR) (95% confidence interval). Mediation analyses were conducted to examine if above target HbA1c mediated these relationships.ResultsThe cohort included 407 and 902 women with Type 1 and 2 diabetes, respectively, of whom 25.1% and 34.5% missed at least one appointment. Women with Type 1 diabetes who missed an appointment were more likely to have a caesarean section (aOR 1.95 [1.15, 3.31]) and their babies more likely to be admitted to the neonatal intensive care unit (aOR 2.25 [1.35, 3.75]). Women with Type 2 diabetes who missed an appointment were more likely to have a large‐for‐gestational‐age infant (aOR 1.61 [1.13, 2.28]), and an extreme large‐for‐gestational‐age infant (aOR 1.69 [1.02, 2.81]) compared with women who did not miss appointments. Above target HbA1c mediated the relationship between missed appointments and caesarean delivery in Type 1 diabetes and large‐for‐gestational age and extreme large‐for‐gestational age in Type 2 diabetes.ConclusionIn individuals with Type 1 and 2 diabetes, there are differences in neonatal outcomes between those who missed an appointment compared to those who did not. It remains unclear if missed diabetes appointments are causative or a marker of other health behaviours or risk factors leading to neonatal morbidity.
Different patterns of exosomal α‐synuclein between Parkinson's disease and probable rapid eye movement sleep behavior disorder
Authors: Yan Yi‐Qun , Pu Jia‐Li , Zheng Ran , Fang Yi , Gu Lu‐Yan , Guo Tao , Si Xiao‐Li , Zhou Cheng , Chen Ying , Liu Yi , Guan Xiao‐Jun , Xu Xiao‐Jun , Yan Ya‐Ping , Yin Xin‐Zhen , Zhang Min‐Ming , Tao Zhi‐Hua , Zhang Bao‐Rong 
Published: September 2022

AbstractBackground and purposeThe insidious onset of Parkinson's disease (PD) makes early diagnosis difficult. Notably, idiopathic rapid eye movement sleep behavior disorder (iRBD) was reported as a prodrome of PD, which may represent a breakthrough for the early diagnosis of PD. However, currently there is no reliable biomarker for PD diagnosis. Considering that α‐synuclein (α‐Syn) and neuroinflammation are known to develop prior to the onset of clinical symptoms in PD, it was hypothesized that plasma total exosomal α‐Syn (t‐exo α‐Syn), neural‐derived exosomal α‐Syn (n‐exo α‐Syn) and exosomal apoptosis‐associated speck‐like protein containing a caspase activation and recruitment domain (ASC) may be potential biomarkers of PD.MethodsIn this study, 78 PD patients, 153 probable iRBD patients (pRBD) and 63 healthy controls (HCs) were recruited. α‐Syn concentrations were measured using a one‐step paramagnetic particle‐based chemiluminescence immunoassay, and ASC levels were measured using the Ella system.ResultsIt was found that t‐exo α‐Syn was significantly increased in the PD group compared to the pRBD and HC groups (p < 0.0001), whilst n‐exo α‐Syn levels were significantly increased in both the PD and pRBD groups compared to HCs (p < 0.0001). Furthermore, although no difference was found in ASC levels between the PD and pRBD groups, there was a positive correlation between ASC and α‐Syn in exosomes.ConclusionsOur results suggest that both t‐exo α‐Syn and n‐exo α‐Syn were elevated in the PD group, whilst only n‐exo α‐Syn was elevated in the pRBD group. Additionally, the adaptor protein of inflammasome ASC is correlated with α‐Syn and may facilitate synucleinopathy.
A stated preference survey to explore patient preferences for novel preventive migraine treatments
Authors: Hubig Lena T. , Smith Timothy , Chua Gin Nie , Lloyd Andrew J. , Powell Lauren , Johnston Karissa , Harris Linda , L'Italien Gilbert , Coric Vladimir , Lo Siu Hing 
Published: September 2022

AbstractObjectiveThe objective of this study was to explore patient preference for attributes of calcitonin gene‐related peptide (CGRP) inhibitors for the preventive treatment of migraine and to describe differences in treatment preferences between patients.BackgroundCGRP inhibitors are a novel class of migraine drugs specifically developed for the preventive treatment of migraine. Clinicians should understand patient preferences for CGRP inhibitors to inform and support prescribing choices.MethodsPatients with migraine in the US and Germany were recruited to participate in an online discrete choice experiment (DCE) survey, which presented hypothetical treatment choices using five attributes: mode of administration, side effects, migraine frequency, migraine severity, and consistency of treatment effectiveness. Attribute selection was informed by a literature review and semi‐structured patient interviews (n = 35), and evaluated using patient cognitive debriefing interviews (n = 5).ResultsOf 680 who consented to participate, 506 participants completed the survey and were included in the study (US = 257; Germany = 249). Overall, participants placed highest importance (preference weight, beta = 1.65, p < 0.001) on the treatment's ability to reduce the severity of migraine (mild vs. unchanged severity), followed by consistent treatment effectiveness (beta = 1.13, p < 0.001), and higher chance of reduced migraine frequency (beta = 1.00, p < 0.001). Participants preferred an oral tablet every other day (beta = 1.00, p < 0.001) over quarterly infusion, quarterly injections (p = 0.019), or monthly injection (p < 0.001). Preference for all treatment attributes were heterogeneous, and the subgroup analyses found that participants naïve to CGRP monoclonal antibody treatments had a stronger preference for oral therapy compared to those with such experience (p = 0.006).ConclusionIn this DCE assessing CGRP inhibitors attributes, the main driver of patient choice was treatment effectiveness, specifically reduced migraine severity, and consistent treatment effectiveness. Further, patients exhibited an overall preference for an oral tablet every other day over injectables. Patients' experience with previous treatments informs the value they place on treatment characteristics.
Helicobacter pylori and cardiovascular risk: Only a dead Helicobacter is a good Helicobacter?
Authors: Wernly Sarah , Semmler Georg , Völkerer Andreas , Flamm Maria , Aigner Elmar , Niederseer David , Wernly Bernhard , Datz Christian 
Published: September 2022

AbstractObjectivesHelicobacter pylori (H. pylori) and cardiovascular (CV) disease share common symptoms and underlie many general medical complaints. Preliminary studies suggest an association between H. pylori positivity and CV risk, and gastroenterological guidelines recommend eradication of H. pylori in patients with manifest atherosclerosis. Therefore, the aim of this study was to examine the reciprocal association of H. pylori positivity and CV risk for their independence of shared risk factors.MethodsWe included 3284 asymptomatic participants of a colorectal cancer screening cohort who were offered and underwent upper gastrointestinal endoscopy. We calculated the 10‐year risk for a CV event using the novel SCORE2 for each patient. We evaluated the association between H. pylori positivity and CV risk assessed by SCORE2 using both multilevel logistic and linear regression. We adjusted for age, sex and the concomitant diagnosis of metabolic syndrome. Lastly, we assessed the association between H. pylori status and mortality using proportional hazard Cox regression.ResultsIn total, 2659 patients were H. pylori negative and 625 H. pylori positive. Helicobacter pylori positivity was associated with SCORE2 and remained so (r = .33; 95% CI 0.09–0.57; p = .006) after adjustment for age, sex, and the diagnosis of metabolic syndrome. Also, SCORE2 was associated with higher odds for H. pylori positivity (aOR 1.03 95% CI 1.01–1.05; p = .02) even after multivariable adjustment. Helicobacter pylori positivity was associated with neither CV (HR 0.60 95% CI 0.14–2.63; p = .50) nor all‐cause (HR 1.20 95% CI 0.77–1.87; p = .43) mortality during a median follow‐up of 9 years.ConclusionsIn our study, H. pylori positivity and CV risk were independently associated. This did not translate into a dissimilar CV mortality between H. pylori positive and H. pylori negative patients. However, the overwhelming majority of our patients underwent H. pylori eradication. We, therefore, think that H. pylori eradication is at least safe from a cardiovascular perspective and warranted from gastrointestinal standpoint.
The perceived fair duration of unemployment benefits for older workers. The role of lifetime achievements in the labour market
Authors: Senghaas Monika , Osiander Christopher , Stephan Gesine , Struck Olaf , Wolff Richard 
Published: September 2022

AbstractThe welfare state regulates social policies and reallocates scarce resources. For the social legitimacy of the welfare state, it is important that the public supports the principles underlying this reallocation. This article examines the impact of different activities during the life course on public deservingness perceptions of older unemployed people. In a factorial survey experiment conducted among a random sample of individuals drawn from German administrative employment records, we examine the maximum duration of benefit receipt which is perceived as fair for older unemployed persons with different biographies. The results indicate strong public support for a nexus between previous contributions and benefit entitlements. Besides financial contributions to unemployment insurance, parenting and further training are considered to be ‘lifetime achievements’ which justify longer unemployment benefit receipt. We interpret these findings as an expression of a generalised form of reciprocity which guides perceptions of deservingness regarding older unemployed persons.