bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cathepsin F is a potential marker for senescent human skin fibroblasts and keratinocytes associated with skin aging
Authors: Takaya Kento , Asou Toru , Kishi Kazuo 
Published: September 2022

Abstract Cellular senescence is characterized by cell cycle arrest and the senescence-associated secretory phenotype (SASP) and can be triggered by a variety of stimuli, including deoxyribonucleic acid (DNA) damage, oxidative stress, and telomere exhaustion. Cellular senescence is associated with skin aging, and identification of specific markers of senescent cells is essential for development of targeted therapies. Cathepsin F (CTSF) has been implicated in dermatitis and various cancers and participates in cell immortalization through its association with Bcl family proteins. It is a candidate therapeutic target to specifically label and eliminate human skin fibroblasts and keratinocytes immortalized by aging and achieve skin rejuvenation. In this study, we investigated whether CTSF is associated with senescence in human fibroblasts and keratinocytes. In senescence models, created using replicative aging, ionizing radiation exposure, and the anticancer drug doxorubicin, various senescence markers were observed, such as senescence-associated β-galactosidase (SA-β-gal) activity, increased SASP gene expression, and decreased uptake of the proliferation marker BrdU. Furthermore, CTSF expression was elevated at the gene and protein levels. In addition, CTSF-positive cells were abundant in aged human epidermis and in some parts of the dermis. In the population of senescent cells with arrested division, the number of CTSF-positive cells was significantly higher than that in the proliferating cell population. These results suggest that CTSF is a candidate for therapeutic modalities targeting aging fibroblasts and keratinocytes.
When Markets Aren’t Markets: a Reply to David Rondel
Authors: Dillingh Savriël 
Published: September 2022

AbstractIn a recent article in this journal, David Rondel argues that symbolic (or semiotic) objections to markets hold significant argumentative force. Rondel distinguishes betweenIncidentalmarkets andPervasivemarkets, where Incidental markets describe individual instances of exchange and Pervasive markets comprise the social management of goods by an institutional market arrangement. In this reply, I specify a key insight that buttresses Rondel’s distinction. The distinction as it is currently characterized fails to identify when Incidental markets become Pervasive. This opaqueness allows scholars that defend markets without limits to question the analytical distinctiveness of Incidental and Pervasive markets. I show that by incorporating the market’s price mechanism as an indicator of a properly Pervasive market, Rondel’s distinction is not only able to tackle the aforementioned retort, but also allows for important reflections on what types of institutions should be considered markets at all.
Enhancement of instrumented ultrasonic tracking images using deep learning
Authors: Maneas Efthymios , Hauptmann Andreas , Alles Erwin J. , Xia Wenfeng , Noimark Sacha , David Anna L. , Arridge Simon , Desjardins Adrien E. 
Published: September 2022

Abstract
Purpose:
Instrumented ultrasonic tracking provides needle localisation during ultrasound-guided minimally invasive percutaneous procedures. Here, a post-processing framework based on a convolutional neural network (CNN) is proposed to improve the spatial resolution of ultrasonic tracking images.

Methods:
The custom ultrasonic tracking system comprised a needle with an integrated fibre-optic ultrasound (US) transmitter and a clinical US probe for receiving those transmissions and for acquiring B-mode US images. For post-processing of tracking images reconstructed from the received fibre-optic US transmissions, a recently-developed framework based on ResNet architecture, trained with a purely synthetic dataset, was employed. A preliminary evaluation of this framework was performed with data acquired from needle insertions in the heart of a fetal sheep in vivo. The axial and lateral spatial resolution of the tracking images were used as performance metrics of the trained network.

Results:
Application of the CNN yielded improvements in the spatial resolution of the tracking images. In three needle insertions, in which the tip depth ranged from 23.9 to 38.4 mm, the lateral resolution improved from 2.11 to 1.58 mm, and the axial resolution improved from 1.29 to 0.46 mm.

Conclusion:
The results provide strong indications of the potential of CNNs to improve the spatial resolution of ultrasonic tracking images and thereby to increase the accuracy of needle tip localisation. These improvements could have broad applicability and impact across multiple clinical fields, which could lead to improvements in procedural efficiency and reductions in risk of complications.
The amelioration of degraded larch (Larix olgensis) soil depends on the proportion of Aralia elata litter in larch-A. elata agroforestry systems
Authors: Gao Pingzhen , Zhu Jiaojun , Yan Qiaoling , Yang Kai , Zhang Jinxin 
Published: September 2022

AbstractResearch has indicated that introducing Aralia elata into larch plantations forms an agroforestry system which could provide economic benefits for local farmers and improve degraded soils. However, the impact of litter mixtures on soil chemical and microbial properties in this agroforestry system are unclear, which limits efficient management of the agroforestry system. A 365-d incubation experiment examined the effect of litter mixtures of different proportions of larch (L) and A. elata (A) on soil chemical and microbial properties. The results show that levels of mineral N, available P, microbial biomass carbon and nitrogen, cumulative C mineralization, and activities of hydrolases and oxidases increased with an increase of A. elata in the litter mixtures. Concentration of total soil carbon, nitrogen, and phosphorous did not change (except for total nitrogen). Compared with larch litter alone, levels of mineral N, available P, microbial biomass carbon and nitrogen, cumulative C mineralization, and the activities of hydrolases and oxidases increased by 7.6–433.5%. Most chemical and microbial properties were positively correlated with mixed litter proportions and the initial levels of N, P, K, Ca, Mg, Mn, Zn and Cu in the litter, while negatively correlated with the initial concentrations of C, Fe and lignin, C/N and lignin/N ratios. The results indicate that A. elata litter can improve degraded larch soil and the degree depends on the proportion of A. elata litter in the litter mixtures.
Roles of technologies for future teaching in a pandemic: activity, agency, and humans-with-media
Authors: Villa-Ochoa Jhony Alexander , Molina-Toro Juan Fernando , Borba Marcelo C. 
Published: September 2022

AbstractResearch literature on the role of mathematics teachers during the COVID-19 crisis shows that teacher preparation for emergency situations is required. In reporting on this exploratory study, we present and analyse lesson plans created by seven future teachers for mathematics classes during the pandemic. Data were collected between April and October 2021 from 16 four-hour class sessions in a Mathematics Degree Program at a public university in Medellín, Colombia. The notion of Humans-with-Media and the Learning by Expanding theory were used as frameworks to understand what roles prospective mathematics teacher (PMTs) assign to technologies for teaching in pandemic conditions. The PMTs’ uses of technology for teaching mathematics during a pandemic were categorized. The results show that technology was used to reorganize and reproduce mathematics teaching practices. This report addresses the impact of technology on the activity system, and we conclude with a discussion of opportunities and limitations of students’ conceptions about teaching and technology during a pandemic.
DNA barcoding to assess species identification in museum samples of Amphiliidae and natural samples of Cichlidae from Southern Mozambique
Authors: Ferrari Claudio , Tovela Erica , Taviani Elisa , Nonnis Marzano Francesco 
Published: September 2022

AbstractThe biodiversity protection and monitorning is one of main goals of natural history musems worldwide. Conservation issues are particularly important for freshwater fish which are one of the most threatened taxa for the consequences of climate change and human activies. In Mozambique freshwater rivers are poorly explored and the impact of aquaculture and human activities on local biodiversity in almost unknown. Here we propose the barcoding analysis of cytochrome c oxidase I (COI) mitochrondrial DNA of 41 frehswater fishes catched in four rivers of southern Mozambique and 53 from a museum collection. As evidence of previous knowledge gaps, barcoding results revealed twenty new haplotypes described for the first time in the taxa Cichlidae and Amphilidae. From a methodological point of view, the barcoding approach demonstrated a critical point connected to the requested 650 bp length of amplified sequences. In fact, high weight genomic DNA is unattainable from museum samples and also in wildlife samples collected in pristine rivers. For this reason we furtherly tested the efficiency of DNA mini-barcoding analysis for 53 fish from a museum collection. The Mini-barcode method retrieved 56.6% of sequences successfully analyzed versus 3% of barcoding. The high performance of this thecniques is discussed in relation to biodiversity monitoring and to fill the taxonomy gaps in museum collections.
A Pragmatic Randomized Controlled Trial Targeting Perfectionism in Young Adolescents
Authors: Osenk Ivana , Johnson Catherine , Wade Tracey D. 
Published: September 2022

AbstractPerfectionism has adverse impacts on mental health and academic outcomes. We evaluated a 5-lesson classroom intervention for young adolescents delivered by teachers for impact on perfectionism, well-being, self-compassion, academic motivation and negative affect, at post-intervention and 3-month follow-up. Classes (N = 636 students, Mage = 13.68, SD = 0.60) were randomized to intervention (n = 343) or classes as usual (n = 293). Data were analyzed using linear mixed models adjusted for baseline observation and clustering. At post-intervention no differences were found between the groups. At 3-month follow-up, anxiety showed a significant increase in the control group with no increase in the intervention group (d = 0.23; 95% CI: 0.05, 0.40); females in the control group had a significant decrease in well-being from post-intervention to 3 month follow-up compared to the intervention group (d = 0.33; 95% CI: 0.08, 0.58); students with high levels of perfectionistic concerns in the intervention had significantly lower perfectionistic strivings at 3 month follow-up than the control group ((d = 0.34, 95% CI: 0.19, 0.49). This intervention shows promising results when delivered by teachers. Australian New Zealand Clinical Trials Registry (ANZCTR) Trial Number: ACTRN12621000457842 (April 19, 2021).
Congenital Mandibular Hypoplasia: Patient-Specific Total Joint Replacement as a Line Extension in the Treatment of Complex Craniofacial Anomalies
Authors: Zimmerer Rüdiger M. , Sander Anna Katharina , Schönfeld Annika , Lethaus Bernd , Gellrich Nils-Claudius , Neuhaus Michael-Tobias 
Published: September 2022

Abstract
Introduction
Congenital mandibular hypoplasia (CMH) remains challenging because of the underlying combined hard and soft tissue deficiency. Treatment options include craniofacial distraction, orthognathic surgery, and autologous grafts, although the latter produces inadequate results after distraction and autologous grafting. Unsatisfactory long-term stability may cause relapse, necessitating reoperation.

Material and Methods
We investigated the feasibility of using alloplastic total joint replacement (TJR) in growing and young adult CMH patients. The primary outcome was long-term reconstruction stability, without implant failure. Secondary outcomes were TMJ function and pain, and jaw movements achieved during surgery.

Results
Three patients (age: 9–22 years) were treated by the same surgeon at one institution during 2018–2021. Anamnesis and clinical parameters were obtained from patient records. Preoperative 3D-scans were superimposed with postoperative 3D-scans and preoperative plans, including TJR-implant STL files, to measure jaw movement. All patients underwent prior reconstructive surgery. Mandibular movement of 16.4–20.1 mm in the sagittal direction was achieved. Post-TJR follow-up ranged from 24 to 42 months. No long-term complications occurred. At the latest follow-up, the maximal interincisal opening was between 21 and 40 mm, and all implants were functioning, without failure.

Conclusion
In selected CMH cases, alloplastic TJR can deliver satisfactory medium-term results with predictable and stable outcomes, even in growing patients.
A New Ratio-Metric pH Probe, “ThiAKS Green” for Live-Cell pH Measurements
Authors: Akyol Ali , Baykal Doruk , Akdağ Akın , Şensoy Özge , Son Çağdaş Devrim 
Published: September 2022

AbstractDeviation of the H+ concentration from optimum values within the organelles is closely associated with irregular cellular functions that cause the onset of various diseases. Therefore, determining subcellular pH values in live cells and tissues is valuable for diagnostic purposes. In this study, we report a novel ratiometric fluorescence probe 1H-pyrazole-3-carboxylic acid, 4-(benzo[d]thiazol-2-yl)-3-(2,4-dihydroxy-3-methylphenyl)-1H-pyrazole-5-carboxylicacid4-(2-benz othiazolyl)-5-(2,4-dihydroxy-3-methylphenyl), to which we will refer as ThiAKS Green (Thiazole AKyol shifting green), that is pH sensitive. The results presented here show that the probe can penetrate the cell membrane in less than 30 minutes and does not show any detectable toxicity. The measured color shifts up on pH change are linear and most significant around physiological pH (pKa=7.45), thus making this probe suitable for live-cell imaging and intracellular pH measurements. During the long-incubation periods following the application of the probe and the fluorescent microscopy measurements, it shows stable properties and is easy to detect in live cells. In conclusion, the results suggest that ThiAKS Green can be used to obtain precise information on the H+ distribution at various compartments of the live cells.
A Broadband Achromatic Dielectric Planar Metalens in Mid-IR Range
Authors: Yuan Ye , Yan Zilong , Zhang Peifeng , Chang Zhu , Peng Fengjiang , Chen Ruotong , Yang Zhenyuan , Chen Shizheng , Zhao Qing , Huang Xiaoping 
Published: September 2022

AbstractMetalens are planar lenses composed of the subwavelength arrays, which have unconventional and versatile functionalities to manipulate the light fields compared with the traditional lens. It is noted that the most metalens are designed in a monochromatic mode in the visible or mid-infrared range (mid-IR), however, the broadband range is needed in many practical applications, such as spectroscopy, sensing, and imaging. Here, we design and demonstrate a broadband achromatic dielectric metalens in the mid-IR range of 4 µm–5 µm for near diffraction-limited (1.0λ) focusing. The broadband achromatic propagation and focusing of the metalens are designed and simulated by constructing and optimizing the phase profile. The Pancharatnam-Berry (P-B) phases of all the elements contribute to the main phase increment of the whole phase profile of the metalens. The additional phase is constructed and optimized by using the random search algorithm to obtain the optimized size of all the elements. The focusing efficiency of the achromatic metalens is also optimized and averaged as the result of phase optimization within a wide band for the building elements, while it is lowered comparing with the regular metalens without broadband achromatic designing. Using this combined designing approach, various flat achromatic devices with the broadband metalens can find a new way for full-color detection and imaging.
The Cheeger cut and Cheeger problem in metric graphs
Authors: Mazón José M. 
Published: September 2022

AbstractFor discrete weighted graphs there is sufficient literature about the Cheeger cut and the Cheeger problem, but for metric graphs there are few results about these problems. Our aim is to study the Cheeger cut and the Cheeger problem in metric graphs. For that, we use the concept of total variation and perimeter in metric graphs introduced in Mazón (Math Eng 5(1):1–38, 2023.https://doi.org/10.3934/mine.2023009), which takes into account the jumps at the vertices of the functions of bounded variation. Moreover, we study the eigenvalue problem for the minus 1-Laplacian operator in metric graphs, whereby we give a method to solve the optimal Cheeger cut problem.
The effects of exercise training induced calories expenditure on type 2 diabetes related cardio metabolic physiological parameters and adipocytokines
Authors: zadeh Mahmoud Asle Mohammadi , Afrasyabi Saleh , Mohamadi Zaynab Asle 
Published: September 2022

Abstract
Background
Recently, many studies have examined the effects of various training on pro-inflammatory and anti-inflammatory adipocytes. The results of these studies are contradictory. Some have reported positive effects and others have reported negative effects. However, there is no research to study the effect of exercise on similar energy expenditures on adipocytes. Hence the purpose of this study was the effects exercise training induced calories expenditure on type 2 diabetes related cardio metabolic physiological parameters and adipocytokines.

Methods
Sixty-eight men patients with type 2 diabetes [12 weeks] were randomized to 4 groups according to training regimens. the groups are [1] HIIT [n = 17], [2] RT[n = 17], [3] AT[n = 18], and [4] AT + RT n = 16]. For 12 weeks [4 days/week, 20–30 min/season], participants performed training sessions with 300 kcal energy expenditure. Before and after 12 weeks interventions, Anthropometric and physiological variables and Glucose, insulin, FFA, LDL, HDL, TG, TC collected and analyses. Leptin, SFRP5, LGR4 and Irisin levels in Serum were assessment by ELISA.

Results
Serum irisin concentrations were significantly higher in AT [%20.4] compared to other groups. Leptin, SFRP5 and LGR4 were significantly higher in HIIT [%-21.7, %48.1 and %30.9 respectively] compared to other groups. Serum SFRP5 concentrations were significantly increased in 4 groups[P > 0.05]. However, leptin and LGR4 were significantly decreased and increased in 3 groups expect in RT group[P > 0.05]. And irisin concentrations were significantly increased in AT group only[P > 0.05]. And many variables indicated positive and negative relationship between together [P > 0.05].

Conclusions
The findings of the present study showed that if exercised with energy expenditure equal to HIIT training, it has the greatest effect on improving inflammatory and anti-inflammatory indicators in type 2 diabetic patients, as well as glycemic and lipid-chemical variables.
‘What is important is seldom urgent and what is urgent is seldom important’: a study of the strategic implications of the urgency effect in a competitive setting
Authors: Papi Mauro 
Published: September 2022

AbstractThe urgency effect refers to people’s tendency to choose a relatively unimportant task (with unambiguously low payoff) over a relatively important task (with unambiguously high payoff), when the former is spuriously framed as urgent. In this paper I study a simple model in which two payoff-maximising task suppliers compete for a population of heterogeneous decision-makers. Task suppliers offer tasks of various importance, and can exert costly effort to manipulate the perceived urgency of the offered tasks. Decision-makers are of two kinds: they either choose more important over less important tasks by disregarding the urgency frames (fully rational) or behave like fully rational decision-makers, except that they are subject to the urgency effect (boundedly rational). I study the unique symmetric equilibrium of the resulting game and derive the conditions under which the urgency effect has detrimental effects on the decision-makers’ welfare. Furthermore, I examine the implications of several policies aimed at correcting the failure, which include educating boundedly rational decision-makers and auditing task suppliers that use urgency framing.
Analyzing the Application of the Sustainable Development Goals for Egypt Using a Neutrosophic Goal Programming Approach
Authors: Badr Elsayed , Seidy Essam El , Elrayes Amani , Rabie Aya 
Published: September 2022

Abstract
Sustainable development necessitates the implementation of appropriate policies that integrate multiple competing objectives on economic, environmental, energy, and social criteria. Multi-criteria decision analysis with goal programming is a popular and widely used technique for studying decision problems with multiple competing objectives. Real-world situations frequently involve imprecise and incomplete information, making neutrosophic goal programming models the most appealing option. We presented a novel neutrosophic goal programming model that incorporates optimal resource allocation to simultaneously satisfy prospective goals on economic development, energy consumption, workforce, and greenhouse gas emission reduction by 2030, as applied to Egypt’s key economic sectors in this paper. We also compared the outcomes of fuzzy goal programming and neutrosophic goal programming. We show that neutrosophic goal programming approach is more accurate than fuzzy goal programming approach because it deals with incomplete and indeterminate information and has three independent degrees: truth membership degree, indeterminacy–membership degree, and falsity–membership degree. The presented model examines opportunities for improvement and the effort required to implement sustainable development plans. The model also provides valuable insights to decision makers for strategic planning as well as investment allocations for sustainable development. Numerical illustration is also provided for validation and application of the proposed model.
Strategic sentiments and emotions in post-Second World War party manifestos in Finland
Authors: Koljonen Juha , Öhman Emily , Ahonen Pertti , Mattila Mikko 
Published: September 2022

AbstractWe contribute to the growing number of studies on emotions and politics by investigating how political parties strategically use sentiments and emotions in party manifestos. We use computational methods in examining changes of sentiments and emotions in Finnish party manifestos from 1945 to 2019. We use sentiment and emotion lexicons first translated from English into Finnish and then modified for the purposes of our study. We analyze how the use of emotions and sentiments differs between government and opposition parties depending on their left/right ideology and the specific type of party manifesto. In addition to traditional sentiment and emotion analysis, we use emotion intensity analysis. Our results indicate that in Finland, government and opposition parties do not differ substantially from each other in their use of emotional language. From a historical perspective, the individual emotions used in party manifestos have persisted, but changes have taken place in the intensity of using emotion words. We also find that in comparison with other parties, populist parties both appeal to different emotions and appeal to the same emotions with different intensities.