bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of preoperative white blood cell count on long-term outcome in patients undergoing surgery for colorectal cancer: A retrospective observational study of Chinese patients
Authors: Wang Bei , Li Lihong , Wang Shilai , Zhou Changming , Sun Zhirong , Weng Meilin 
Published: June 2022

Abstract
PurposeThe correlation between preoperative white blood cell (WBC) count and the outcome in patients who underwent surgery for colorectal cancer (CRC) was evaluated in present study.Patients and methods:A total of 8121 Chinese patients at Fudan University Shanghai Cancer Center (FUSCC) undergoing colectomy, Dixon’s or Mile’s, for CRC from January 2008 to December 2014 were enrolled in present study. Based on that the WBC optimal cut-off value was 7*109, the patients were divided into two groups, the moderate leukocytosis group (the leukocytosis group) and non-leukocytosis group. The impact of preoperative WBC count on disease-free survival (DFS) and overall survival (OS) was investigated using the Kaplan-Meier method and Cox proportional hazard models.ResultsModerate leukocytosis (≥7*109) was recognized as a prognostic factor for survival independently. Moderate leukocytosis was significantly associated with male sex (P＜0.001), advanced T stage (P＜0.001), TNM stage (P＜0.001), and no preoperative chemotherapy (P＜0.001). Moderate leukocytosis group was corelated with poorer overall survival (OS) (P＜0.001) and disease-free survival (DFS) (P = 0.024) than non-leukocytosis group. In the multivariate analysis, the moderate leukocytosis group had a 19.6% higher risk in OS (HR = 1.196, 95CI%:1.088–1.314, P < 0.001) and had a 13.1% higher risk in DFS (HR = 1.131, 95CI%:1.016–1.259, P = 0.024) than the non-leukocytosis group. We found that the association with preoperative moderate leukocytosis and poorer OS (P＜0.001) or DFS (P=0.001) in patients with no preoperative chemotherapy in subgroup analysis.ConclusionsPreoperative moderate leukocytosis is associated with shorter OS, DFS indicating poor outcome in CRC patients after surgery.
Cervical X-ray versus CT scan: Radiologic Findings in Traumatic Cervical Spine Injury in Emergency Department
Authors: Seyedrezaei Seyedeh Omolbanin , Mahdavi Sepideh , Noyani Amir , Joukar Farzaneh , Largani Hossein Amiri 
Published: June 2022

Abstract
Objective: Head and neck trauma are among the most common reasons for referring to hospitals’ emergency departments. This study aimed to compare cervical X-ray and CT scans’ accuracy in diagnosing cervical spine injuries in trauma patients in Shahroud city.Materials and Methods: The present study is a cross-sectional study on patients with traumatic cervical injuries referred to the emergency department of Imam Hossein Hospital in Shahroud city from 2018 to 2019. Both cervical X-rays and CT scans were used for all patients. Firstly, the radiography, then CT scans were performed. An emergency medicine specialist and a radiologist examined crvical X-rays and CT scans separately for diagnosing cervical spine injuries. In this paper, CT scan findings were considered as the gold standard. Sensitivity, specificity, positive and negative predictive value, positive and negative likelihood were used to determine the diagnostic value of plain radiography compared to CT scan. The Kappa agreement coefficient was also calculated.Results: Out of 115 participants, 7.8% (9 patients) had cervical spine injuries period 59.1% were male, and 40.9% were female. The mean age of patients was 39.8 ± 15.3 years. Car accidents, rollover, and motorcycle accidents with 39.1, 24.3, and 20.9%, respectively, were the most common mechanisms of causing injuries in these patients. Sensitivity, specificity, positive and negative predictive value, positive and negative likelihood ratios for cervical X-ray were 55.56, 97.17, 62.5, 26.26, 96, 19.63, and 0.46%, respectively.Conclusion: According to the present study results, the accuracy of cervical X-ray compared to CT scan in diagnosing injuries occurred to the cervical spine due to trauma is low because the sensitivity of cervical X-rays in detecting injuries is very low. Therefore, it seems that the cervical X-ray cannot be considered as a suitable tool to rule out cervical spine injuries caused by trauma.
Artificial Intelligence-Based Intravenous Fluid Monitoring and Control System for Health Care Using WSN
Authors: M Sudha , Kandasamy Ravisankar 
Published: June 2022

Abstract
In recent years the wireless sensor networks plays a vital role in the medical field. WSN designed for medical application is referred to as Wireless Medical Sensor Network. In recent years, due to technological advancements; many jet-set techniques have been evolved for assuring fast recovery of the patients in hospitals. From the day, where the IV fluid enters into medical field a nurse or caretaker is responsible for the monitoring of intravenous fluid level continuously. The control of IV fluid flow is done through a flow sensor with a Bluetooth connection. Similarly, ECG and EEG are responsible for the monitoring of heart beat and oxygen level and there is no mobile application for control purpose. These problems are overcome using WSN and Artificial Intelligence which is the emerging technology in the latest years. With the help of this P2N (Patient to Nurse Intercommunication system) the patient’s status is continuously monitored.
Thiol-Ene crosslinked cellulose-based gel polymer electrolyte with good structural integrity for high cycling performance lithium-metal battery
Authors: Zhang Hongbing , Wang Yujie , Dong Shuhan , Chen Wen , Yu Feng , Chen Yong 
Published: June 2022

Abstract
Gel polymer electrolytes (GPEs) are considered the most promising replacements for liquid electrolytes that can be easily applied with long-life, safe, and solid-state lithium-metal batteries. However, the mechanical properties of GPE usually deteriorate dramatically when plasticized by the liquid electrolyte, which results in a significant decrease in the performance of the battery. Therefore, the long-term structural integrity and desirable mechanical strength are critical parameters for GPE to be ustilized in the high-performance battery. Here, an environment-friendly cellulose-based GPE is crosslinked by simple and effective thiol-ene click chemistry. The thiol-ene crosslinked GPE not only possesses higher mechanical strength (10.95 MPa) and rigid structure, but also enables the LiFePO4|Li batteries with ultra-long cycling stability. The capacity retention of crosslinked cellulose GPE can reach to 84% at 0.5C even after 350 cycles, which is much better than the non-crosslinked GPE suffering a rapid capacity decline after 200 cycles. This work provides a promising GPE to replace the commercial liquid electrolyte for lithium metal battery.
Human embryonic stem cell-specific role of YAP in maintenance of self-renewal and survival
Authors: Choe Mu Seog , Bae Chang Min , Kim So Jin , Oh Seung Taek , Kwon Yu Jin , Choi Won-young , Baek Kyung Min , Chang Woochul , Kim Joong Sun , Lim Kyung Seob , Yun Seung Pil , Lee Min Young 
Published: June 2022

Abstract
Human embryonic stem cells (hESCs) have unique characteristics, i.e., self-renewal and pluripotency, that are clearly distinct from those of other types of cells. These characteristics of hESCs are tightly regulated by complex signaling mechanisms. In this study, we show that the yes-associated protein (YAP) functions in an hESC-specific manner to maintain self-renewal and survival in hESCs. hESCs reacted highly sensitively to YAP downregulation for cell survival. Interestingly, hESC displayed dynamic changes of YAP expression in response to YAP downregulation. Our results also demonstrated that YAP is critical for the maintenance of self-renewal. Meanwhile, we found that doxycycline upregulated YAP in hESCs and attenuated the decrease in cell survival induced by YAP downregulation. However, neither the decrease in the expression of self-renewal markers triggered by YAP downregulation nor neural/cardiac differentiation was affected by doxycycline treatment. Collectively, the results of this study revealed the mechanism underlying the role of YAP as well as a novel function of doxycycline in hESCs.
Mariculture carbon sink efficiency in China: Measurements and driving factors
Authors: Shi Xiuyi , Xu Yingzhi , Dong Biying , Nishino Nariaki 
Published: June 2022

Abstract
A measurements of China’s mariculture carbon sink efficiency (MCSE) and its driving factors analysis are conducted in this paper. First, based on the Super-SBM model, the panel data from 9 Chinese coastal provinces (autonomous regions) during 2015–2019 are used to measure the MCSE in China. Second, the STRIPAT method and ridge regression method are used to explore the driving factors of China’s MCSE. Third, a blueprint for China to achieve carbon neutrality is constructed, and the advantages of mariculture carbon sink are summarized. The results show that the mariculture carbon sink has a high carbon store and carbon flux, and it has a dual value of ecology and economy. Meanwhile, mariculture carbon sink has the less negative impacts on eco-environment. Further, the MCSE, on the whole, of the 9 coastal regions in China presents an upward trend in 2015–2019, and this trend is more significant in the Pan-Pearl River Delta (PPRD) and Circum-Bohai Sea (CBS) Economic Zone. In 2019, 66.67% of the regions in the sample is the SBM-efficient DMUs on technical efficiency (TE), and 88.89% of the regions in the sample is the BSM-efficient DMUs on pure technical efficiency (PTE). Finally, driving factors analysis shows that the affluence and service industry of a region may have a positive impact on the MCSE, while the population, urbanization and international trade may have a negative impact on the MCSE to a certain extent.
Improved Outcome in Penile Cancer With Radiologically Enhanced Stratification Protocol for Lymph Node Staging Procedures: A 12-year Study in 316 Inguinal Basins
Authors: Kumar Vivekanandan , Kumar Prakrit Raj , Juette Arne , Pawaroo Davina , Ball Richard Y , Sethia Krishna K 
Published: June 2022

Abstract
BackgroundLymph node metastasis is the main determinant of survival in penile cancer patients. Conventionally clinical palpability is used to stratify patients to Inguinal Lymph node dissection (ILND) if clinically node positive (cN+) or Dynamic sentinel node biopsy (DSNB) if clinically node negative (cN0). Studies suggest a false negative rate (FNR) of around 10% (5-13%) for DSNB. To our knowledge there are no studies reporting harder end point of survival and outcomes of all clinically node positive (cN+) patients. We present our outcome data of all patients with penile cancer including false negative rates and survival in both DSNB and ILND groups. Methods158 consecutive patients (316 inguinal basins), who had lymph node surgery for penile cancer in a tertiary referral centre from Jan 2008 to 2018, were included in the study. All patients underwent ultrasound (US) +/-fine needle aspiration cytology (FNAC) and then MRI/ CT, if needed, to stage their disease. We used combined clinical and radiological criteria (node size, architecture loss, irregular margins) to stratify patients to DSNB vs ILND as opposed to clinical palpability alone. Results11.2 % i.e., 27/241 inguinal basins had lymph node positive disease by DSNB. 54.9% i.e., 39/71 inguinal basins (IBs) had lymph node-positive disease by ILND. 4 inguinal basins with no tracer uptake in sentinel node scans are being monitored at patient’s request and have not had any recurrences to date. With a mean follow-up of 65 months (range 24-150), the false-negative rate (FNR) for DSNB is 0%. Judicious uses of cross-sectional imaging necessitated ILND in 2 inguinal basins with non-palpable nodes and negative US with false positive rate of 6.3% (2/32) for ILND.ConclusionCombined clinical and radiological stratification of patients achieved a 0% false-negative rate for DSNB at a mean follow-up of 65 months. The same cohort of DSNB patients might have had 11.1% (3/27) FNR if only palpability criteria was used. 43 (28%) patients who did require cross sectional imaging as per our criteria had a low node positive rate of 4.7% (p=0.03). Mean cancer specific survival of all node-positive patients was 105 months.
Rapamycin nanoparticles improves drug bioavailability in PLAM treatment by interstitial injection
Authors: Shi Yahong , Jiao Chuqiao , Lu Xi , Nie Yifeng , Li Xiang , Han Dong 
Published: June 2022

Abstract
Background: Pulmonary lymphangiomyomatosis (PLAM) is a rare interstitial lung disease characterized by diffuse cystic changes caused by the destructive proliferation of smooth muscle-like cells or LAM cells. PLAM is more common in young women than other people, and a consensus is lacking regarding PLAM treatment. The clinical treatment of PLAM is currently dominated by rapamycin. By inhibiting the mTOR signaling pathway, rapamycin can inhibit and delay PLAM’s occurrence and development. However, the application of rapamycin also has shortcomings, including the drug’s low oral bioavailability and a high binding rate to hemoglobin, thus significantly decreasing the amount of drug distributed to the lungs. Methods and results: Here, we developed a new mode of rapamycin administration in which the drug was injected into the intrathecal space after being nanosized; the directional flow characteristics of the liquid in the intrathecal space were exploited to increase the drug content in the interstitial fluid to the greatest extent possible. We studied the rapamycin content in the interstitial fluid and blood after intervaginal space injection (ISI). Compared with oral administration, ISI significantly increased the drug concentration in the lung interstitial fluid. Conclusions: These results provided new ideas for treating PLAM and optimizing the dosing regimens of drugs with similar characteristics to rapamycin.
Association and interaction between metal aluminum and iron exposure and the risk of offspring’ congenital heart defects occurrence in northwestern China
Authors: Li Jing , Zhang Chunhua , Yi Bin , Mao Baohong , Liu Qian , Wang Yanxia , Dai Zhirong , You Chongge , Liu Qing 
Published: June 2022

Abstract
The purpose of this study is to explore the levels of aluminum (Al) and iron (Fe) levels in maternal peripheral blood (MB) and cord blood (CB) and the relationship to the risk of congenital heart defects (CHDs) in the offspring. This matched-based birth cohort study with 194 controls and 97 CHDs-cases (proportion = 2:1) was included in this study. Serum concentrations of Al and Fe were measured by inductively coupled plasma mass spectroscopy. Conditional logistic regression model was employed to evaluate the influence of Al/Fe and its interaction on risk of fetal CHDs, adjusted for confounders. Compared to the low quartiles of Al level in CB, risk differences were significantly detected in the highest quartiles of Al in total CHDs (aOR = 2.826, 95% CI: 1.009–7.266) and isolated CHDs (aOR = 10.713, 95% CI: 1.017–112.851). A significant dose-effect was observed between the Al level and total CHDs in both MB and CB (Ptrend < 0.05). Notably, co-exposure to high Al and Fe elicited a strong correlation on fetal heart development than low Al and low Fe in CB of total CHDs (aOR = 5.273, 95% CI: 1.897–14.657), multiple CHDs (aOR = 7.820, 95% CI: 1.672–36.588), septal defects (aOR = 4.747, 95% CI: 1.428–15.780) and PDA (aOR = 13.147, 95% CI: 2.415–71.565). Our data support that Al exposure(≥2.408 mg/L) poses a major health threat for the risk of CHDs, which can monitor fetal CHDs at-risk pregnancies.
Investigating Customers’ Continuous Trust Towards Mobile Banking Apps
Authors: Che Maohao , Say Sze Yee Ashley , Yu Han , Zhou Qingji , Shu Jared , Sun Wen , Luo Xi , Xu Hong 
Published: June 2022

Abstract
Gaining continuous trust from mobile banking customers is a critical step in retaining customers for their usage of the provided, and continually evolving services. The current study aims to investigate how customers’ continuous trust is formed at the post-use stage. Online survey responses from 450 frequent mobile banking users are collected. The data was analysed using structural equation modelling (SEM) based on a proposed model that predicts trust. The findings successfully validated the model and its reduced form. Based on which, customers’ continuous trust can be predicted by mobile banking apps’ perceived ease of use, privacy assurance and security features, organisation reputation, customer support, and customers’ previous experience. Furthermore, the interactive relationships among these proposed factors are proposed and validated in the model. In studying trust in mobile banking past the initial adoption stage, we present new knowledge on how various factors might interactively inform customers’ continuous trust. It adds to the scant literature on consumers’ continuous trust.
A COMPACT RECTENNA FOR 5G MOBILE COMMUNICATIONS
Authors: Marriwala Nikhil , B Debarpita 
Published: June 2022

Abstract
The aim of this paper is to structure a compact size rectenna for 5G mobile communication. The scale of the antenna is to kept as small as possible here we have considered 18 X 10 X 5 mm and operating frequency of 12GHz. The antenna designed here is probably going to own its applications in mobile communication system. The antenna designed in this project is structured in such a way that it is covering a good wide range of frequency from X-band to Ka-band. The antenna designed have two symmetrical elements which increases gain, reduce return loss and improve bandwidth .And the desired antenna is interfaced with rectifier in order to increase its battery life. In this work we have achieved two resonating frequencies one at 11GHz and 34GHz with return loss at -14dB and − 18.0146dB and gain of 4.36535935watt which is converted to dc power of 4.768 Watts. In this work different parameters like return loss, Gain, Radiation pattern, rectifier design and dc power generated are improved.
Landslide Identification and Deformation Monitoring Analysis in Xining City Based on the Time Series InSAR of Sentinel-1A with Ascending and Descending Orbits
Authors: He Li , Wu Xiantan , He Zhengwei , Xue Dongjian , Bai Wenqian , Kang Guichuan , Chen Xin , Zhang Yuxiang 
Published: June 2022

Abstract

Landslide disasters occur frequently in the Loess Plateau of China, which seriously threatens the economic development and the safety of life and property. Using time-series Interferometric synthetic aperture radar (InSAR) to identify potential active landslides and monitor their deformation is conducive to prevent and reduce the harm caused by disasters. This paper takes Xining City as the research area, using the sentinel-1A radar images ascending orbit and descending orbit, the ground surface deformation rate and time series variables in the study area were obtained by using two time series InSAR technologies of small baseline subset (SBAS) and permanent scatterer (PS).Through the cross inspection of the deformation results detected by SBAS and PS technology, it is found that the deformation characteristics detected by SBAS technology are richer in space, the cumulative deformation variables are more robust, and have more advantages in the identification of active landslides. Compared with GNSS monitoring data, the cumulative deformation of landslide detected by PS technology has better fitting degree and higher accuracy. The experimental results show that time-series InSAR technology can effectively identify and monitor loess landslides, which provides a scientific basis for regional disaster prevention and control.
Diagnostic and Pathogenesis Performance of Circulating miR-146b, miR-194, and miR-214 in Liver Fibrosis
Authors: Aghajanzadeh Taha , Talkhabi Mahmood , Zali Mohammad Reza , Hatami Behzad , Baghaei Kaveh 
Published: June 2022

Abstract
Background
Liver fibrosis is the excessive accumulation of extracellular matrix proteins through the activation of hepatic stellate cells (HSCs). Due to the lack of an accurate test for early diagnosis of liver fibrosis and being invasiveness of the liver biopsy procedure, there is an urgent need for effective non-invasive biomarkers for screening the patients. Here, we aim to evaluate a diagnostic panel of circulating miRNAs (miR-146b, -194, -214) and their related mechanisms in the pathogenesis of liver fibrosis.
Methods
The expression levels of miR-146b, miR-194, and miR-214 were detected in the whole blood of NAFLD patients (N = 34) using real-time PCR (qPCR), and their correlation was calculated with the clinical factors of patients. Next, we constructed the competing endogenous RNA (ceRNA) network and performed a gene set enrichment analysis (GSEA) for HSC activation-related genes. Also, we illustrated the transcription factor (TF)-miR co-regulatory network and analyzed the survival plot for three miRNAs and core genes.
Results
The qPCR results showed that relative expression of miR-146b and miR-214 significantly increased in NAFLD patients, while miR-194 was significantly down-regulated (p < 0.05). miR-146b and miR-214 showed significant correlation with total cholesterol (r = 0.43, p = 0.03) and ALT level (r=-0.56, p = 0.004), respectively. The ceRNA network demonstrated that NEAT1 and XIST sponged candidate miRNAs. Based on GSEA analysis, 15 target mRNA were selected as core genes which are involved in HSC activation, and were mainly enriched in the NF-κB activation and autophagy. STAT3, TCF3, RELA, and RUNX1 were considered potential TFs connected to miRNAs in the TF-miR network.
Conclusions
Our study elucidated three candidate miRNAs differentially expressed in the NAFLD patients’ blood and could serve as a promising non-invasive diagnostic tool for early detection of NAFLD. Also, NF-κB activation, autophagy, and negative regulation of apoptotic process are the main potential underlying mechanisms regulated by these miRNAs in the liver fibrosis pathogenesis.