bluuebunny/crossref_metadata_2025_split huggingface dataset:
ZNF384 Fusion Oncoproteins Drive Lineage Aberrancy in Acute Leukemia
Authors: Dickerson Kirsten M. , Qu Chunxu , Gao Qingsong , Iacobucci Ilaria , Gu Zhaohui , Yoshihara Hiroki , Backhaus Emily A. , Chang Yunchao , Janke Laura J. , Xu Beisi , Wu Gang , Papachristou Evangelia K. , D'Santos Clive S. , Roberts Kathryn G. , Mullighan Charles G. 
Published: April 2022

Abstract

ZNF384-rearranged fusion oncoproteins (FO) define a subset of lineage ambiguous leukemias, but their mechanistic role in leukemogenesis and lineage ambiguity is poorly understood. Using viral expression in mouse and human hematopoietic stem and progenitor cells (HSPC) and a Ep300::Znf384 knockin mouse model, we show that ZNF384 FO promote hematopoietic expansion, myeloid lineage skewing, and self-renewal. In mouse HSPCs, concomitant lesions, such as NRASG12D, were required for fully penetrant leukemia, whereas in human HSPCs, expression of ZNF384 FO drove B/myeloid leukemia, with sensitivity of a ZNF384-rearranged xenograft to FLT3 inhibition in vivo. Mechanistically, ZNF384 FO occupy a subset of predominantly intragenic/enhancer regions with increased histone 3 lysine acetylation and deregulate expression of hematopoietic stem cell transcription factors. These data define a paradigm for FO-driven lineage ambiguous leukemia, in which expression in HSPCs results in deregulation of lineage-specific genes and hematopoietic skewing, progressing to full leukemia in the context of proliferative stress.

Significance:
Expression of ZNF384 FO early in hematopoiesis results in binding and deregulation of key hematopoietic regulators, skewing of hematopoiesis, and priming for leukemic transformation. These results reveal the interplay between cell of origin and expression of ZNF384 FO to mediate lineage ambiguity and leukemia development.
This article is highlighted in the In This Issue feature, p. 171
PHACTR-1 (Phosphatase and Actin Regulator 1) Deficiency in Either Endothelial or Smooth Muscle Cells Does Not Predispose Mice to Nonatherosclerotic Arteriopathies in 3 Transgenic Mice
Authors: Rubin Sébastien , Bougaran Pauline , Martin Soizic , Abelanet Alice , Delobel Valentin , Pernot Mathieu , Jeanningros Sylvie , Bats Marie-Lise , Combe Christian , Dufourcq Pascale , Debette Stéphanie , Couffinhal Thierry , Duplàa Cécile 
Published: April 2022

Background:
Genome-wide association studies have revealed robust associations of common genetic polymorphisms in an intron of the PHACTR-1 (phosphatase and actin regulator 1) gene (chr6p24), with cervical artery dissection, spontaneous coronary artery dissection, and fibromuscular dysplasia. The aim was to assess its role in the pathogenesis of cervical artery dissection or fibromuscular dysplasia.

Methods:

Using various tissue-specific Cre-driver mouse lines,
Phactr1
was deleted either in endothelial cells using 2 tissue-specific Cre-driver (PDGFB [platelet-derived growth factor B]-Cre
ERT2
mice and Tie2 [tyrosine kinase with immunoglobulin and EGF homology domains]-Cre) and smooth muscle cells (smooth muscle actin-Cre
ERT2
) with a third tissue-specific Cre-driver.

Results:

To test the efficacy of the
Phactr1
deletion after cre-induction, we confirmed first, a decrease in Phactr1 transcription and Phactr1 expression in endothelial cell and smooth muscle cell isolated from Phactr1
iPDGFB
and Phactr1
iSMA
mice. Irrespective to the tissue or the duration of the deletion, mice did not spontaneously display pathological phenotype or vascular impairment: mouse survival, growth, blood pressure, large vessel morphology, or actin organization were not different in knockout mice than their comparatives littermates. Challenging vascular function and repair either by angiotensin II–induced hypertension or limb ischemia did not lead to vascular morphology or function impairment in Phactr1-deleted mice. Similarly, there were no more consequences of
Phactr1
deletion during embryogenesis in endothelial cells.

Conclusions:
Loss of PHACTR-1 function in the cells involved in vascular physiology does not appear to induce a pathological vascular phenotype. The in vivo effect of the intronic variation described in genome-wide association studies is unlikely to involve downregulation in PHACTR-1 expression.
The Impact of Edge Displacement Vaserstein Distance on UD Parsing Performance
Authors: Anderson Mark , Gómez-Rodríguez Carlos 
Published: April 2022

Abstract
We contribute to the discussion on parsing performance in NLP by introducing a measurement that evaluates the differences between the distributions of edge displacement (the directed distance of edges) seen in training and test data. We hypothesize that this measurement will be related to differences observed in parsing performance across treebanks. We motivate this by building upon previous work and then attempt to falsify this hypothesis by using a number of statistical methods. We establish that there is a statistical correlation between this measurement and parsing performance even when controlling for potential covariants. We then use this to establish a sampling technique that gives us an adversarial and complementary split. This gives an idea of the lower and upper bounds of parsing systems for a given treebank in lieu of freshly sampled data. In a broader sense, the methodology presented here can act as a reference for future correlation-based exploratory work in NLP.
Tractable Parsing for CCGs of Bounded Degree
Authors: Schiffer Lena Katharina , Kuhlmann Marco , Satta Giorgio 
Published: April 2022

Abstract
Unlike other mildly context-sensitive formalisms, Combinatory Categorial Grammar (CCG) cannot be parsed in polynomial time when the size of the grammar is taken into account. Refining this result, we show that the parsing complexity of CCG is exponential only in the maximum degree of composition. When that degree is fixed, parsing can be carried out in polynomial time. Our finding is interesting from a linguistic perspective because a bounded degree of composition has been suggested as a universal constraint on natural language grammar. Moreover, ours is the first complexity result for a version of CCG that includes substitution rules, which are used in practical grammars but have been ignored in theoretical work.
Review essay: ‘Constitutional lawyers are Dutchmen’
Authors: Wijffels Alain 
Published: April 2022

Summary
V. Bogdanor’s Beyond Brexit (2019) is a constitutional lawyer’s argument in favour of a codified constitution for the United Kingdom. During the UK’s temporary membership of the European Communities and European Union (1973-2020), main features of the constitution which still prevailed in the 1960s have changed. The author discusses parliamentary sovereignty, referendums, collective government responsibility, human rights, and devolution.
Note minime sul ius dotium in Marziano Capella
Authors: Bono Francesco 
Published: April 2022

Summary
Martianus Capella’s De nuptiis Philologiae et Mercurii, 9.898, echoes ancient jurisprudence, not only because the divinity Saturnus is depicted as a jurist, but because the passage also refers to a jurisprudential rule on dowries. The text suggests that dotem dicere is possible after a marriage has been celebrated. Legal authorities (both imperial constitutions and works by jurists) show that Saturnus’ words are consistent with principles of Roman law on dowries.
Urban privileges (‘keuren’) in medieval Flanders: charters or dynamic legal documents?
Authors: Declercq Georges 
Published: April 2022

Summary
Between 1163 and 1240 urban privileges in the county of Flanders often lack the formal characteristics typical of medieval charters. They consist solely of a list of legal articles preceded by a general heading. In Flanders, such formless law texts are traditionally known as ‘keuren’. The most famous of these documents is the so-called ‘Grote Keure’ by which Count Philip of Alsace imposed a uniform criminal law on the major towns in his realm between 1165 and 1175. In this paper, I argue that these formless law texts are dynamic legal documents that could be updated whenever this was necessary: obsolete clauses were omitted, other passages were modified and new articles were added as time went by. At first, these changes were made to the Latin texts of the ‘keuren’. In a second stage they were translated into the vernacular and these French or Dutch versions then became the basis for further changes.
The imperial policy against heretics of restricting succession in the fourth century AD, with an appendix on the Theodosian Code
Authors: Sirks Boudewijn 
Published: April 2022

Summary
A distinctive common feature of the measures against heretics and apostates in the 4th century AD is that their rights regarding successions are being curtailed or even removed. How was that done and is here a general policy visible? And what was the purpose behind these measures? Was it merely the wish of relatives to keep assets in the family as Riedlberger suggests, or was it to prevent that these sects became affluent, or perhaps was there a theological dimension to it? Since the essential texts derive from the Theodosian Code, this collection of imperial constitutions is discussed as well.
Evaluating the Effect of Semantic Congruency and Valence on Multisensory Integration
Authors: Letts Elyse , Basharat Aysha , Barnett-Cowan Michael 
Published: April 2022

Abstract
Previous studies have found that semantics, the higher-level meaning of stimuli, can impact multisensory integration; however, less is known about the effect of valence, an affective response to stimuli. This study investigated the effects of both semantic congruency and valence of non-speech audiovisual stimuli on multisensory integration via response time (RT) and temporal-order judgement (TOJ) tasks [assessing processing speed (RT), Point of Subjective Simultaneity (PSS), and time window when multisensory stimuli are likely to be perceived as simultaneous (temporal binding window; TBW)]. Through an online study with 40 participants (mean age: 26.25 years; females = 17), we found that both congruence and valence had a significant main effect on RT (congruency and positive valence decrease RT) and an interaction effect (congruent/positive valence condition being significantly faster than all others). For TOJ, there was a significant main effect of valence and a significant interaction effect where positive valence (compared to negative valence) and the congruent/positive condition (compared to all other conditions) required visual stimuli to be presented significantly earlier than auditory stimuli to be perceived as simultaneous. A subsequent analysis showed a positive correlation between TBW width and RT (as TBW widens, RT increases) for the categories that were furthest from true simultaneity in their PSS (Congruent/Positive and Incongruent/Negative). This study provides new evidence that supports previous research on semantic congruency and presents a novel incorporation of valence into behavioural responses.
Synopsis of the Neotropical Sclerodermus Latreille (Hymenoptera, Bethylidae) with description of a new species attacking human beings
Authors: AZEVEDO CELSO O. , COLOMBO WESLEY D. 
Published: April 2022

We provide a Neotropical synopsis of the genus Sclerodermus Latreille. The genus is recognized by having the antenna with 11 flagellomeres, the head globoid or nearly so, the eyes present and flat, and the clypeal median lobe strongly angled and deeply separated from the lateral lobes. The strong polymorphism of having wings is an intra- and intergeneric feature and the macropterous specimens are diagnosed by having forewings with the pterostigma slender and only the R cell closed. In this synopsis we recognized seven previously known species: S. formicarius Kieffer, S. galapagensis Brues, S. iridomyrmicicola Bruch, S. macrogaster (Ashmead), S. soror Westwood, S. spilonotum Evans, and S. wilsoni Evans. The type-species, S. domesticus Latreille is also included, but their occurrence in the Neotropical Region is in doubt. Additionally, we discovered one more species, S. chicomendesi n. sp., which is described and illustrated, based on both sexes with molecular support. This species was found attacking a woman in her office in Porto Alegre, Brazil, where there was wood furniture with holes bored by beetles of the Ptinidae genus Tricorynus Waterhouse. We also provide a key to the Neotropical species of this genus and a discussion about species attacking human beings.
Tornado Radar Images and Path Directions: An Assessment of Public Knowledge in the Southeastern United States
Authors: Senkbeil Jason C. , Sherman-Morris Kathleen , Skeeter Walker , Vaughn Cole 
Published: April 2022

Abstract
Due to the current use and reliance on tornado warning polygons, several published articles have concentrated on themes related to risk perception and interpretation of risk within and outside of polygons. Despite the general success of warning polygons, not everybody is able to spatially estimate their risk by looking at maps with tornado warning polygons. Using polygons in conjunction with radar images can improve comprehension and better inform protective action decision-making for tornado warnings. Additionally, a potential latent area of research is how past tornado tracks and climatological knowledge about tornado path directions may influence tornado risk perception and protective action decision-making. In this study, we surveyed 1023 individuals across the southeastern United States. Participants were asked to rate their level of concern for a tornadic supercell moving toward two locations. They were also asked to name the direction tornadoes usually come from and travel toward in their counties. Results indicated significantly more concern about the radar reflectivity within the supercell than concern about the location of the hook echo. Additionally, the perceived directions of tornado paths across the region were inaccurate with 75 percent of the sample either not answering, indicating that they did not know the most common direction for tornado paths, or answering that tornadoes travel in uncommon or unrealistic path directions. The Atlanta metropolitan area was used as a case study to illustrate inaccurate perceptions of path directions.
Subseasonal-to-Seasonal Arctic Sea Ice Forecast Skill Improvement from Sea Ice Concentration Assimilation
Authors: Zhang Yong-Fei , Bushuk Mitchell , Winton Michael , Hurlin Bill , Delworth Thomas , Harrison Matthew , Jia Liwei , Lu Feiyu , Rosati Anthony , Yang Xiaosong 
Published: April 2022

Abstract
The current GFDL seasonal prediction system, the Seamless System for Prediction and Earth System Research (SPEAR), has shown skillful prediction of Arctic sea ice extent with atmosphere and ocean constrained by observations. In this study we present improvements in subseasonal and seasonal predictions of Arctic sea ice by directly assimilating sea ice observations. The sea ice initial conditions from a data assimilation (DA) system that assimilates satellite sea ice concentration (SIC) observations are used to produce a set of reforecast experiments (IceDA) starting from the first day of each month from 1992 to 2017. Our evaluation of daily sea ice extent prediction skill concludes that the SPEAR system generally outperforms the anomaly persistence forecast at lead times beyond 1 month. We primarily focus our analysis on daily gridcell-level sea ice fields. SIC DA improves prediction skill of SIC forecasts prominently in the June-, July-, August-, and September-initialized reforecasts. We evaluate two additional user-oriented metrics: the ice-free probability (IFP) and ice-free date (IFD). IFP is the probability of a grid cell experiencing ice-free conditions in a given year, and IFD is the first date on which a grid cell is ice free. A combined analysis of IFP and IFD demonstrates that the SPEAR model can make skillful predictions of local ice melt as early as May, with modest improvements from SIC DA.
A Bayesian Hierarchical Framework for Postprocessing Daily Streamflow Simulations across a River Network
Authors: Ossandón Álvaro , J. S. Nanditha , Mendoza Pablo A. , Rajagopalan Balaji , Mishra Vimal 
Published: April 2022

Abstract
Despite the potential and increasing interest in physically based hydrological models for streamflow forecasting applications, they are constrained in terms of agility to generate ensembles. Hence, we develop and test a Bayesian hierarchical model (BHM) to postprocess physically based hydrologic model simulations at multiple sites on a river network, with the aim to generate probabilistic information (i.e., ensembles) and improve raw model skill. We apply our BHM framework to daily summer (July–August) streamflow simulations at five stations located in the Narmada River basin in central India, forcing the Variable Infiltration Capacity (VIC) model with observed rainfall. In this approach, daily observed streamflow at each station is modeled with a conditionally independent probability density function with time varying distribution parameters, which are modeled as a linear function of potential covariates that include VIC outputs and meteorological variables. Using suitable priors on the parameters, posterior parameters and predictive posterior distributions—and thus ensembles—of daily streamflow are obtained. The best BHM model considers a gamma distribution and uses VIC streamflow and a nonlinear covariate formulated as the product of VIC streamflow and 2-day precipitation spatially averaged across the area between the current and upstream station. The second covariate enables correcting the time delay in flow peaks and nonsystematic biases in VIC streamflow. The results show that the BHM postprocessor increases probabilistic skill in 60% compared to raw VIC simulations, providing reliable ensembles for most sites. This modeling approach can be extended to combine forecasts from multiple sources and provide skillful multimodel ensemble forecasts.
Impedance Planimetry and the Changing Paradigm of Esophageal Dysphagia
Authors: Makamson Luci M. , Holm Tyler E. , Jenkins Hayley N. , Mehaffey Niall A. , Mansour Emily A. , Coleman Thomas P. , Norton Christian H. , Walker Savannah C. , McClain Jessica E. , Parker Adam C. , Brousse Brandon R. , Schaefer David C. , Kutcher Matthew E. , Moremen Jacob R. 
Published: April 2022

Objectives Patients presenting with dysphagia can encounter a pathway to therapy and relief that is expensive and frustrating. High resolution impedance planimetry (HRIP) is a new mechanism for enhancing and possibly hastening that process. A balloon with integrated pressure sensors is utilized to measure luminal geometry and pressure by volume-controlled distention. Esophagogastric junction (EGJ) distensibility and body contractility are assessed at the time of other endoscopic procedures. Here we describe a single-center experience utilizing HRIP in the endoscopic evaluation of patients presenting with dysphagia. Methods A prospectively maintained registry of patients undergoing impedance planimetry assessments at an academic medical center was queried for demographics, procedural details, and patient-reported outcomes. Results Data was reviewed for 122 procedures performed by two providers. HRIP was performed in 63 (52%) patients for initial dysphagia assessment, 36 (30%) for follow-up assessment, and 20 (16%) as a procedural adjunct at the time of other planned procedures. HRIP contractile response was characterized as normal in 36%, absent in 32%, and diminished/disorganized in 14%. These results motivated clinical planning for surgical referral in 7 (5%) patients, 31 (26%) additional testing, and 82 (68%) continued medical management and follow-up. Discussion HRIP is an emerging endoscopic modality which can streamline diagnostic work-up and therapeutic planning for patients with symptomatic dysphagia. Using functional esophageal assessment at the time of other diagnostic and therapeutic procedures, HRIP may expedite care and lead to improved patient satisfaction and clinical outcomes.
Through the Eyes of Dr Sherman—That 10 Percent
Authors: Aaland Mary 
Published: April 2022

As chief of surgery at Grady Memorial Hospital in Atlanta Roger Sherman trained generations of trauma surgeons, including me. Our relationship had three phases, each with a specific lesson that stayed with me throughout my career: first, the interview for a fellowship; second, my training at Grady, or “Grady 101;” and third, relating to important people outside of surgical practice, which I understood to be “that 10 percent” that really, really disliked me. I was caught during a time when there was a severe contraction of the number of training programs in surgery. Despite the red flag of having gone to four different residencies, Dr. Sherman still decided to offer me fellowship position. Training at Grady meant seeing more patients with severe trauma and burns than most surgeons see in a lifetime, with an autonomy that was coupled with responsibility and the expectation of accountability. The 10 percent often included non-surgical consultants and administrators that might be adversarial at first but could provide support if they were informed about the impact of their decisions on patients. Being part of Dr. Sherman’s staff was a privilege. In his words “surgery … is an awesome responsibility afforded to only a few … a high honor surpassed only by being trusted to teach others this demanding and marvelous craft.”
Indigenous strengths-based approaches to healthcare and health professions education – Recognising the value of Elders’ teachings
Authors: Kennedy Andrea , Sehgal Anika , Szabo Joanna , McGowan Katharine , Lindstrom Gabrielle , Roach Pamela , Crowshoe Lynden (Lindsay) , Barnabe Cheryl 
Published: April 2022

Background A strengths-based lens is essential for the pursuit of health equity among Indigenous populations. However, health professionals are often taught and supported in practice via deficit-based approaches that perpetuate inequity for Indigenous peoples. Deficit narratives in healthcare and health education are reproduced through practices and policies that ignore Indigenous strengths, disregard human rights, and reproduce structural inequalities. When strengths are recognised it is possible to build capacities and address challenges, while not losing sight of the structural factors impacting Indigenous peoples’ health. Objective In this paper, we examine Indigenous strengths-based approaches to policy and practice in healthcare and health professions education when delivered alongside teachings shared by Elders from the Cree, Blackfoot and Métis Nations of Alberta, Canada. Method Literature and Elders’ teachings were used to shift strengths-based approaches from Western descriptions of what might be done, to concrete actions aligned with Indigenous ways. Results Four pointers for future action adopting a strengths-based approach are identified: enacting gifts – focusing on positive attributes; upholding relationality – centring good relationships; honouring legacy – restoring self-determination; and reconciling truth – attending to structural determinants of health. Conclusion Identified directions and actionable strategies offer a promising means to advance Indigenous health equity through strengths-based actions that change existing narratives and advance health equity.