bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sleep quality of patients with papillary thyroid carcinoma: A prospective longitudinal study with 5-year follow-up
Authors: Koo Dae Lim , Park Yangmi , Nam Hyunwoo , Chai Young Jun 
Published: August 2022

Abstract
We evaluated the pre- and postoperative sleep quality of patients with newly diagnosed papillary thyroid carcinoma (PTC) who underwent thyroid surgery, and investigated the factors associated with persistent poor sleep quality. The Pittsburgh Sleep Quality Index (PSQI), Epworth Sleepiness Scale, and Stanford Sleepiness Scale were used to estimate sleep quality and daytime sleepiness. Face-to-face surveys were conducted preoperatively, and 1, 4, and 10 months after thyroid surgery. The PSQI was administered during a telephone interview about after 5 years after surgery. Forty-six patients (mean age 47.3 ± 10.1 years) with PTC (11 males, 35 females) were included in this study. Twenty-one participants underwent lobectomy and twenty-five underwent total thyroidectomy. Preoperatively, 35 (76.1%) patients showed poor sleep quality. PSQI scores at postoperative 1, 4, and 10 months were significantly lower than preoperative scores (p < 0.001). Postoperative 5-year PSQI scores decreased significantly compared to the preoperative scores (p < 0.001). Patients newly diagnosed with PTC suffered from sleep disturbance before and after surgery for at least 10 months, recovering to a comparable rate of sleep disturbance with the general population by 5 years after surgery. Higher preoperative PSQI score was at risk for prolonged poor sleep quality in patients with PTC.
Deep learning for automatic diagnosis of fundus diseases on optical coherence tomography images
Authors: Yang Songyang , Wang Qian , Huang Xia , Du Min , Li Jiao , Wang Ruifeng , Chen Peng 
Published: August 2022

Abstract
Background
There has been increasing attention on the use of deep learning systems and transfer learning to identify disease features and progression. In this study, we aimed to apply deep learning algorithms to Optical coherence tomography (OCT) images to quickly identify common referable fundus diseases.
Method
A total of 24000 OCT images (test 1) retrospectively acquired from the Kaggle database with age-related macular degeneration, choroidal neovascularization, central serous chorioretinopathy, diabetic macular edema, diabetic retinopathy, drusen, macular hole, and NOR were used to develop the model. Images were split into training, validation, and testing sets. The convolutional neural networks ResNet101 and DenseNet121 were trained to classify images. The area under the receiver operating characteristic curve (AUC), accuracy, and F1 score were calculated to evaluate the performance of the models. A total of 800 OCT images (test 2) diagnosed with the above eight diseases were collected from the Zhengzhou Eye Hospital to retest the accuracy of the models.
Results
ResNet101 performed better than DenseNet121 did. The classification performance in terms of accuracy and F1 score of ResNet101 were 0.9398 and 0.9360, respectively, in test 2. The AUC of ResNet101 for the eight diseases based on test 2 were 0.9956 (macro-average) and 0.9932 (micro-average). When using DenseNet121 in test 2, the accuracy was 0.7130, and the F1 score was 0.7116. The macro-average AUC was 0.8519, and the micro-average AUC was 0.8366.
Conclusions
Convolutional neural network ResNet101 and transfer learning showed good performance in discriminating between OCT images. As a promising adjunctive tool, our model can provide rapid provisional diagnosis for patients with common referable fundus diseases.
Aerosol Jet Printing of Piezoelectric Surface Acoustic Wave Thermometer
Authors: Deng Zhangxian , McKibben Nicholas , Ryel Blake , Estrada David , Daw Joshua 
Published: August 2022

Abstract
Surface acoustic wave (SAW) transducers are a subclass of micro-electromechanical systems (MEMS) that generate an acoustic emission when electrically stimulated. These transducers can also convert surface strain into readable electrical signals. By monitoring variations in scattering parameters, a SAW device can detect physical properties of host structures and external factors like temperature. Traditional fabrication of SAW transducers requires labor- and cost-intensive subtractive processes that produce large volumes of hazardous waste. This study utilizes an innovative aerosol jet printer to fabricate SAW transducers by directly writing consistent, high-resolution, silver comb electrodes onto a Y-cut LiNbO3 piezoelectric substrate. The printed, two-port, 20 MHz SAW transducers were validated as a thermometer, which exhibited excellent linearity and repeatability from 25 °C to 200 °C. Sensitivities of the printed SAW thermometer are -96.9×10-6 °C-1 and -92.0×10-6 °C-1 when operating in pulse-echo mode and pulse-receiver mode, respectively. These results highlight a repeatable path to additively manufacture compact and high-frequency SAW transducers.
Immune response to SARS-CoV-2 infections in children with secondary immunodeficiencies
Authors: Kuczborska Karolina , Krzemińska Ewelina , Buda Piotr , Heropolitańska-Pliszka Edyta , Piątosa Barbara , Książyk Janusz 
Published: August 2022

Abstract
Background and PurposeIt is a matter of research, whether children with immunodeficiencies are able to generate an effective immune response to prevent SARS-CoV-2 reinfection. This study aimed to evaluate and compare the seroconversion rates and cellular immunity to COVID-19 in immunocompetent children and those with secondary immunodeficiencies. MethodsIn 55 children — 28 immunocompromised and 27 immunocompetent — hospitalized with confirmed SARS-CoV-2 infection, the level of IgG antibodies against the Spike protein was determined on two to three occasions. In those children from the study group, whose immunosuppressive treatment did not alter during the study (n=13) and in selected children from the control group (n=11), flow-cytometric evaluation of lymphocyte subsets was performed twice — two weeks and three months post-infection. ResultsSeroconversion reached 96.3% in both studied groups, however, the immunocompromised cohort achieved lower titers of detectable anti-S antibodies. There was no correlation between seroconversion or titers of antibodies and the total number of lymphocytes or their subsets. In the immunocompetent cohort, we reported a significant decrease in NK cells during the infection. In this group and the entire study population, a positive correlation was noticed between the CD4+/CD8+ T cell ratio and the severity of COVID-19 pneumonia. ConclusionsChildren with secondary immunodeficiencies seroconvert in equal percentages but with a significantly lower titer of anti-S antibodies compared to their immunocompetent peers. Lower number of NK cells in the immunocompetent cohort may result from their participation in antiviral immunity. Whereas reduced CD4+/CD8+ T cell ratios among immunocompromised children can be a protective factor against a severe COVID-19.
PVA coated AgNPs/SiO2 for detection of gentian violet with high sensitivity
Authors: Xu Yanru , Wang Yanqing , Jia Zhiyong 
Published: August 2022

Abstract
Improving the detection limit of surface-enhanced Raman scattering (SERS) is a significant issue for the design and preparation of plasmon substrate. It always suffers from the weak absorption affinity of probe molecules on nanoscale surface, uncontrollable aggregation behaviors of nanoparticles and strong fluorescence of detected substance. In this paper, AgNPs/SiO2 substrate is prepared by rapid thermal annealing method with mean size of 87.9 ± 30.7 nm. A layer of 5–30 nm PVA (polyvinyl alcohol) film is used as the stabilizer of AgNPs. With PVA coating, AgNPs can improve the detection limit of gentian violet by three magnitudes, compared with that on undecorated AgNPs which is just 10− 5 mol/L. In the sensitive detection of coated AgNPs/SiO2 substrate, PVA possibly play three significant roles, absorption increaser between gentian violet and silver nanoparticles, fluorescence inhibiter of gentian violet and stabilizer of Ag nanoparticles. The results provide a modification method for improving SERS sensitivity of plasmon substrate, which use convenient and low-cost rapid thermal annealing as the patterning method and PVA as the coater, an advantageous technology for plasmon substrate application into trace detection.
Persistent headache after first-ever ischemic stroke: clinical characteristics and factors associated with its development
Authors: Lebedeva Elena R. , Ushenin Anton V. , Gurary Natalia M. , Gilev Denis V. , Kislyak Nadezda V. , Olesen Jes 
Published: August 2022

Abstract
Background It is poorly described how often headache attributed to stroke continues for more than 3 months, i.e. fulfils the criteria for persistent headache attributed to ischemic stroke. Our aims were: 1) to determine the incidence of persistent headache attributed to past first-ever ischemic stroke (International headache society categories 6.1.1.2); 2) to describe their characteristics and acute treatment; 3) to analyse the prevalence of medication overuse headache in patients with persistent headache after stroke; 4) to evaluate factors associated with the development of persistent headache after stroke.Methods The study population consisted of 550 patients (mean age 63.1, 54% males) with first-ever ischemic stroke, among them 529 patients were followed up at least three months after stroke. Standardized semi-structured interview forms were used to evaluate these headaches during professional face-to-face interviews at stroke onset and telephone interviews at 3 months.Results At three months, 61 patients (30 women and 31 men, the mean age 60.0) of 529 (11.5%) follow-up patients had a headache after stroke: 34 had a new type of headache, 21 had a headache with altered characteristics and 6 patients had a headache without any changes. Therefore 55 (10.4%) patients had a persistent headache attributed to ischemic stroke. Their clinical features included: less severity of accompanying symptoms, slowly decreasing frequency and development of medication overuse headache in one-third of the patients. The following factors were associated with these headaches: lack of sleep (29.1%, p = 0.009; ОR 2.3; 95% CI 1.2–4.3), infarct in cerebellum (18.2%, p = 0.003; OR 3.0; 95% CI 1.4–6.6), stroke of undetermined etiology (50.9%, p = 0.003; ОR 2.3; 95% CI 1.3–4.1), less than 8 points by NIHSS score (90.9%, p = 0.007; OR 3.4; 95% CI 1.4–8.6) and low prevalence of large-artery atherosclerosis (12.7%, p = 0.006; OR 0.3; 95% CI 0.2–0.80).Conclusion Persistent headache attributed to ischemic stroke is not rare and frequently leads to medication overuse. The problem is often neglected because of other serious consequences of stroke but actually, it has a considerable impact on quality of life. It should be a focus of interest in the follow-up of stroke patients.
Treatments for the control of Neoechinorhynchus buttnerae (Acanthocephala) in tambaqui Colossoma macropomum
Authors: Nunes Bruna Rafaela Caetano , Lopes Yuri Vinicius Andrade , Souza Ricardo Henrique B. , Pazdiora Raul Dirceu , Ushizima Thiago Tetsuo , Medeiros Simone Paiva , Corrêa Lorrayne Tavares , Cardoso Igor Izidoro , Andrade Matheus Vitor Vieira , Maciel-Honda Patricia Oliveira , Chagas Edsandra Campos , Sebastião Fernanda de Alexandre 
Published: August 2022

Abstract

Intensive fish farming with inadequate management can imbalance the fish-pathogen-environment relationship, culminating in diseases outbreaks. In the case of tambaqui Colossoma macropomum farming, it may be affected by acanthocephalosis, a parasitic infection without a specific and safe treatment yet. The objective of this study was to evaluate the effect of the active ingredients in trichlorfon, albendazole, piperazine and ivermectin, as well as calcium hydroxide and diatomaceous earth incorporated to the feed, to control Neoechinorhynchus buttnerae (Acanthocephala) in tambaqui. A 63-day trial was conducted in a completely randomized experimental design, with 7 treatments, 3 replicates each and 54 fish per treatment. Fish were sampled for weight gain and parasite count on days 0, 15, 35, and 63. In general, the efficacy of anthelmintics was low in the treatment of N. buttnerae in tambaqui. Nevertheless, among the tested products, calcium hydroxide and diatomaceous earth showed promising results (48.17% and 36.44% efficacy, respectively), followed by ivermectin and piperazine (15.93% and 12.63%, respectively). Future studies are warranted to test longer drug administration periods, novel products, and diverse experimental conditions to treat N. buttnerae in tambaqui, to provide information to develop strategies for disease management.
Specific energy consumption and heat recovery system of cassava starch production in the integrated agro-industrial system
Authors: Giau Vo , Kien Tran Trung , Thanh Tran Van , Hieu Tran Thi , Thao Nguyen Thi Phuong , Son Le Thanh , Schnitzer Hans , Luu Tran Le , Hai Le Thanh 
Published: August 2022

Abstract
Reducing energy consumption and green house gas emissions is a crucial issue in the cassava starch processing industry. In this study, the integrated system combining livestock, cassava cultivation and cassava production at the same area will lead to both zero emission goal and economic efficiency, a typical example of an effective agro-industrial symbiosis. A heat exchange/recovery system was applied including the economizer, the heat exchanger tank, the biogas tank, and the boiler. The economizer attached to the boiler’s chimney transfers heat from exhaust gases for pre-heating feed water entering boiler. The biogas tank recovers energy from the wastewaters of starch production and livestock farm, and the generated biogas was used as fuel for the boiler. Excess heat from the production was used for evaporating (removal of) NH3 in wastewater flow from the biogas tank, and for heating the biogas system in oder to enhance the efficiency of methane production. A biochar filter was attached to economizer for adsorption of released ammonium, and the biochar after adsorption was combined with sludge from the biogas tank to produce a solid biofertilizer. The energy and exergy efficiency, energy losses, and exergy destruction for heat recovery system were analyzed. The specific energy consumption (SEC) was used to evaluate the overall energy efficiency for cassava starch factory with a capacity of 200 tons/day. The results show that there is a high potential to recyle waste into energy in the cassava starch industry, and the total energy saving and reducing GHG emissions per year of the cassava starch factory were 5.4%/year and 278,773 tons CO2/year, respectively.
Application of Percutaneous Endoscopic Interlaminar Discectomy or Open Lumbar Microdiscectomy in Treating Senile Patients Over 60 Years Old with Symptomatic Lumbar Disc Herniation: A Two-year Retrospective Study
Authors: Liao Ye-Hui , Ye Ru-Pei , Tang Chao , Ma Fei , Tang Qiang , Wang Gaoju , Wang Qing , Zhong Dejun 
Published: August 2022

Abstract
Background: Percutaneous endoscopic interlaminar discectomy (PEID) had been successfully used in the treatment of lumbar disc herniation. However, few reports have focused on the treatment of senile lumbar disc herniation (SLDH) in patients aged over 60 years via PEID. Methods: We included 42 patients with SLDH from January 2019 to June 2020 in this retrospective study. The patients were divided into the PEID group (n = 19) and the open lumbar microdiscectomy (OLM) group (n = 23) according to the type of surgical procedure they underwent. Basic clinical information, surgical information, and clinical effects were compared between the two groups.Results: The estimated blood loss, bed-rest time, and hospital stay in the PEID group were less than those in the OLM group (P < 0.05 each) but the surgery time in the PEID group was longer than that in the OLM group (P < 0.05). The visual analgesia scores for back pain (VAS-BP), visual analgesia scores radiating to the lower legs (VAS-LL), and Oswestry disability index (ODI) scores of the two groups were significantly decreased after surgery compared to the baseline scores (P < 0.05). The VAS-BP at the 1st week and 3rd month post-operation and the ODI at the 12th month and 24th month in the PEID group were lower than those in the OLM group (P < 0.05 each). Conclusion: Both PEID and OLM are safe and efficacious methods of treating SLDH. Compared with OLM, PEID has more advantages in reducing surgical trauma and decreasing postoperative low back pain in the early postoperative period. The long-term clinical results of both techniques seem to be effective without any of them being superior to the other in elderly patients.
Trends of Tourette Syndrome in children From 2011 to 2021: A Bibliometric Analysis
Authors: Yang Cuiling , Zhang Jie , Zhao Qiong , Zhang Jinjing , Zhou Jiang , Wang Li 
Published: August 2022

Abstract
Background
Tourette Syndrome (TS) has attracted the attention of researchers worldwide. However, no bibliometric analysis of the published publications is available. This study aims to examine the present research state of TS in children by CiteSpace, as well as to identify current research hotspots and frontiers.
Method
We chose publications indexed in the Web of Science Core Collection (WoSCC) database for studies related to TS in children from 2011 to 2021. We built online cooperation maps of countries, institutions, authors, journals, references, and keywords by CiteSpace, and identified hotspots and frontiers of study for children's TS.
Results
A total of 1232 publications about TS in children were downloaded from the WoSCC. The USA (414) was the country with the highest rate of production, and University College London (87) was the institution that had the highest publication rate. Andrea Eugenio Cavanna was the most prolific author (39 papers). There was inactive cooperation between institutions, countries, and authors. The Journal of European Child & Adolescent Psychiatry was the most active journal. Hot topics focused on epidemiology, comorbidity, deep brain stimulation, behavioral therapy, pharmacological treatment, and risk factors of TS in children.
Conclusions
According to the CiteSpace results, this study found that authors, countries, and institutions were not actively working together. Current research hotspots mainly consist of epidemiology, comorbidity, deep brain stimulation, and behavioral therapy. The main research trends include comorbidity, pharmacological treatment, and risk factors. Therefore, international cooperation should be strengthened in the future, and it should be mindful of the psychiatric comorbidities of TS, the choice of intervention measures, and early warning of risk factors.
Consensus on an implicit bias and health disparities curriculum in neonatal medicine: a Delphi study
Authors: Mavis Stephanie , Caruso Catherine , Carr Cara , Dyess Nicolle , French Heather , Dadiz Rita , Vasquez Margarita , Johnston Lindsay , Gillam-Krakauer Maria , Chess Patricia , Izatt Susan , Payne Allison , Carbajal Melissa , Bonachea Elizabeth , Gray Megan 
Published: August 2022

Abstract
OBJECTIVEDespite longstanding and recurrent calls for effective implicit bias (IB) education in health professions education as one mechanism to reduce ongoing racism and health disparities, evidence-based IB curricula for neonatal-perinatal medicine (NPM) are limited. We aim to determine the key IB curricular elements for teaching NPM fellows, advanced practice providers, and attending physicians. STUDY DESIGNA modified Delphi study was performed with content experts in IB and health disparities who had educational relationships to those working and training in the neonatal intensive care unit. RESULTThree Delphi rounds were conducted. Experts reached consensus on a variety of items for inclusion in an IB curriculum, including educational goals, learning objectives, teaching strategies, and educator principles.CONCLUSIONEssential IB curricular components for the field of neonatal medicine were defined using rigorous consensus building methodology.
The Role of Socio-cultural learning during and after the COVID-19 Pandemic: Evidence from Indonesia
Authors: Sari Harmita , Hadiansah Deni 
Published: August 2022

Abstract
This research investigates how socio-cultural learning process influences students’ experience and interaction during and after the COVID-19 pandemic which subsequently influencing their E-Learning performance. 734 valid respondents were recruited for an online survey study. Structural Equation Modeling (SEM) was used to test the research hypotheses. This study found that socio-cultural learning has a crucial role in students’ experience and interaction. However, social-cultural learning has a greater effect on students’ experience than students’ interaction. Furthermore, mediator variables, students’ experience and interaction, partially mediate the relationship between socio-cultural learning and E-Learning performance. The result of the current study contributes to extend literature education field toward socio-cultural and E-Learning simultaneously. It also develops a new view into the determinants factor to influence students’ experience and interaction.
Integrated single cell transcriptomics of cerebrospinal fluid cells in early Multiple Sclerosis
Authors: Straeten Frederike , Zhu Jing , Börsch Anna-Lena , Zhang Baohong , Li Kejie , Lu Ina , Gross Catharina , Heming Michael , Li Xiaolin , Rubin Rebekah , Ouyang Zhengyu , Wiendl Heinz , Mingueneau Michael , Hörste Gerd Meyer 
Published: August 2022

Abstract
Multiple sclerosis (MS) is a chronic and often disabling autoimmune disease of the central nervous system (CNS). Cerebrospinal fluid (CSF) surrounds and protects the CNS and analyzing CSF can aid the diagnosis of CNS diseases. Several recent studies have leveraged single cell RNA-sequencing (scRNA-seq) to identify MS-associated changes in CSF cells that are considerably more altered than blood cells in MS. However, not all alterations were replicated across all studies. We therefore integrated multiple available scRNA-seq datasets of CSF cells from MS patients with early relapsing-remitting disease. We provide a searchable and interactive resource of this integrated analysis (https://CSFinMS.bxgenomics.com) facilitating diverse visualization and analysis methods without requiring computational skills. In the present meta-analysis, we replicated the known expansion of B lineage and the recently described expansion of natural killer (NK) cells and some cytotoxic T cells and decrease of monocytes in the CSF in MS. The previous observation of the abundance of Th1-like Th17 effector memory cells in the CSF was not replicated. Expanded CSF B lineage cells resembled class-switched plasma blasts/cells (e.g., SDC1/CD138, MZB1) as expected. Our integrative meta-analysis thus validates increased cell type diversity and B cell maturation in the CSF in MS and improves accessibility of available data.