bluuebunny/crossref_metadata_2025_split huggingface dataset:
Transperineal laser ablation of the prostate with EchoLaser™ system: perioperative and short-term functional and sexual outcomes
Authors: Sessa Francesco , Polverino Paolo , Bisegna Claudio , Siena Giampaolo , Lo Re Mattia , Spatafora Pietro , Pecoraro Alessio , Rivetti Anna , Conte Francesco Lupo , Cocci Andrea , Villari Donata , Minervini Andrea , Gacci Mauro , Li Marzi Vincenzo , Serni Sergio , Campi Riccardo 
Published: August 2022

ObjectiveTo date, several ultra-minimally-invasive surgical techniques are available for the treatment of male LUTS due to benign prostatic obstruction (BPO). Herein we report our preliminary experience with SoracteLite™ TPLA for the treatment of carefully selected patients with LUTS due to BPO.MethodsData from all consecutive patients undergoing TPLA at our institution between April 2021 and February 2022 were prospectively collected in a specific database. Data regarding functional and sexual outcomes evaluated by validated questionnaires and uroflowmetry were analyzed. All the procedure were performed in an outpatient setting, under local anesthesia and conscious sedation, using EchoLaser device, a multisource diode laser generator.ResultsOverall, 38 patients underwent TPLA at our institution during the study period. The median prostate volume was 46 ml (IQR 38-71). The median time to complete the procedure was 31 min (IQR 28-37). All patients but one were discharged within 8 hours of hospital stay. No perioperative Clavien-Dindo grade ≥2 complications were recorded. Median improvement in Qmax was 17%, 24% and 32% at 1 month, 3 months and last follow-up after surgery; as a result, the median postoperative IPSS at 1 month, 3 months and at last follow-up decreased by -14%, -36% and -35%, respectively. All patients preserved ejaculatory and sexual function. Two patients (5%), catheter carriers before the procedure, experienced acute urinary retention after TPLA treatment and required replacement of an indwelling catheter.ConclusionsTPLA can be a feasible, safe and effective ultra-minimally-invasive procedure for carefully selected patients with LUTS due to BPO.
Social Determinants of Health in the COVID-19 Pandemic Context of the Migrant Population Living in Settlements in Spain
Authors: Allande-Cussó Regina , García-Iglesias Juan Jesús , Miranda-Plata Rosario , Pichardo-Hexamer Rocío , Ruiz-Frutos Carlos , Gómez-Salgado Juan 
Published: August 2022

Objectives: The aim of this study was to describe and evaluate the sociodemographic profile and assess the levels of anxiety and fear, work engagement, and psychological distress on a sample of migrants living in settlements in the province of Huelva (Spain) during the COVID-19 pandemic.Methods: A descriptive cross-sectional study was conducted on a sample of 623 migrants during the months of April to June 2021, based on the Anxiety and Fear of COVID-19 (AMICO) assessment scale, the 9-item Utrecht Work Engagement Scale to assess work engagement, and the General Health Questionnaire (GHQ-12) to analyse psychological distress.Results: A low level of education, dwelling of less than 3 m2 and the desire to return to the country of origin may be related to the presence of anxiety and fear of COVID-19 and lower levels of work engagement.Conclusion: There is a need to improve the study of the concept of health of the migrant population residing in the settlements of Huelva (Spain) and the assessment of their physical and mental health, in an official way.
Flipped Classroom Formats in a Problem-Based Learning Course: Experiences of First-Year Bachelor European Public Health Students
Authors: de Jong Nynke , van Rosmalen Peter , Brancaccio Maria Teresa , Bleijlevens Michel H. C. , Verbeek Hilde , Peeters Inge G. P. 
Published: August 2022

Objectives: Students would like to see more creativity and flexibility in the performance of problem-based learning (PBL). Therefore, we applied flipped classroom formats in a course of the Bachelor European Public Health at Maastricht University to investigate the experiences of the students. The main objective was to stimulate interaction between students mutual, and between students and teachers.Methods: 304 first-year students following the course on “Ageing in Europe” in three academic years, were asked to fill out questions focussing on prior knowledge, preparation work, and group session parameters, e.g., duration, content, extent of interaction and format group session.Results: In-class activities, such as debate, making a mind map, giving a pitch, role-play e.g., were highly appreciated by students, especially the interactivity and discussions with the experts during these sessions. Students felt they applied knowledge.Conclusion: Flipped classroom formats can be used to extend the Maastricht University PBL design and students do recommend this. It can be a relevant and challenging answer on the articulated request for more creativity and flexibility in the regular PBL format.
Expression of Estrogen Receptor and Progesterone Receptor in Meningioma Patients
Authors: Prakoso Teguh Iman , Muhammad Thohar Arifin  
Published: August 2022

Background: Meningioma is a primary intracranial benign tumor that is affected by the balance of the estrogen and progesterone hormones. This study aimed to assess the relationship between estrogen receptor (ER) expression and progesterone receptor (PR) expression in meningioma conditions.
Methods: Analytical observational research with a cross-sectional study design. The number of samples is 25 meningioma patients who performed ER and PR examinations. The research was performed at Dr. Kariadi General Hospital Semarang. Statistical test using Spearman test.
Results: Relationship of ER and PR to degree of meningioma is p = 0.181 (r = -0,276) and p = 0,056 (-0,387).
Conclusion: There is no correlation between estrogen receptor (ER) and progesterone (PR) receptor to the degree of meningioma
IMPLEMENTASI PIECES FRAMEWORK DALAM PERANCANGAN E-DOCUMENT MANAGEMENT SYSTEM WEBSITE PUSAT JAMINAN MUTU
Authors: Haryawan Cosmas , Iswanti Sari 
Published: August 2022

The Quality Assurance Center (PJM) is an important unit in a university because it carries out activities in the context of improving the quality of higher education. STMIK AKAKOM as one of the universities also has a PJM Unit, but until now document management is still done in a simple way, namely storing the data and documents on the computer belonging to PJM. Meanwhile, specifically for monitoring results, document need to be printed to be distributed to related parties. Both of these things make it difficult to access by internal or external parties. Electronic Document Management System (E-DMS) is needed to facilitate good document maintenance and management so that documents will be easily stored, searched, updated or shared with other parties and has a security when accessed. In system development, proper analysis and design are needed in order to identify the problem and the solution. Evaluation of the condition of the existing system and result of the design are evaluated using the PIECES Framework. Based on the final results, it can be seen that the E-DMS design for the PJM STMIK AKAKOM obtained good results for the 6 evaluation components, namely Performance, Information, Economics, Controls and Security, Efficiency and Service.
İntrauterin İnseminasyon (IUI) Sonrası Olan İntrauterin İkiz Gebelik ve Sağ Tubal Ektopik Gebelik Olgusu
Authors: KAPLAN İsa 
Published: August 2022

ÖZET
Amaç: Nadiren doğal gebeliklerde oluşan heterotopik gebelikte sıklıkla rüptür sonrası cerrahi tedavi gerekli olduğunda tanı konur. Bu sebeple erken tanı hasta için hayati önem taşımaktadır. Burada rüptüre tubal gebelik ve intrauterin canlı dikoryonik-diamniyotik ikiz gebelik ile prezente olan heterotopik gebelik vakası sunmayı amaçladık.
Olgu: 30 yaşında, nullipar, son adet tarihine göre 6 hafta 3 günlük intruterin inseminasyon ile ( IUI ) gebeliği olan hasta, karın ağrısı ile kliniğimize başvurdu. Yapılan fizik muayenesinde akut batın bulguları mevcuttu. Transvaginal ultrasonografisinde intrauterin yerleşimli 6 hafta 5 gün ve 6 hafta 6 gün ile uyumlu fetal kalp atımı ( FKA ) pozitif olan dikoryonik - diamniyotik ikiz gebelik tespit edildi. Batın içi douglusta yaklaşık 6-7 cm serbest mayi izlendi. Sağ adneksial alanda ektopik odak olabilecek oluşum izlendi. Yapılan tetkiklerinde Hemoglobin: 10.5 gr/dl, β-hcg: 15.000 m IU / ml olarak gelen batın muayenesinde rebaund ve defansı olan hastaya laparotomi planlandı. Laparotomik eksplorasyonda sağ tubal rüptüre ektopik odak izlendi. Batında ortalama 500-600 cc kan ve koagulum izlendi. Uterus ve her iki over normal görünüm ve cesamette izlendi. Sağ total salpenjektomi yapıldı, batın yıkanmasının ardından laparotomiye son verildi. Sağ tubanın patolojik değerlendirme sonucu ektopik gebelik, hematosalpenks olarak geldi. Postoperatif 2. gününde bakılan kontrol ultrason bakısında intrauterin dikoryonik-diamniyotik fetal kalp atımı olan 6 hafta 5 gün ve 6 hafta 6 gün ile uyumlu ikiz gebeliğin devam ettiği görüldü. Hasta postop 4. günde sorunsuz poliklinik kontrolüne gelmek üzere taburcu edildi.
Sonuç: Heterotopik gebelik nadir görülmesi sebebi ile tanı ve tedavide gecikmeler olabilmektedir. Özellikle intrauterin gebelik ultrason bakısında görülen ek yakınması olamayan hastalarda ektopik gebelik atlanabilmektedir. Bu vakamızda buna özellikle dikkat çekmek istedik.
Anahtar kelimeler: Heterotopik gebelik; ikiz gebelik; tubalektopik gebelik
The ALMaQUEST Survey. VIII. What Causes the Discrepancy in the Velocity between the CO and Hα Rotation Curves in Galaxies?
Authors: Su Yung-Chau , Lin Lihwai , Pan Hsi-An , Cobá Carlos López , Hsieh Bau-Ching , Sánchez Sebastián F. , Thorp Mallory D. , Bureau Martin , Ellison Sara L. 
Published: August 2022

Abstract
We compare the CO(1–0) and Hα kinematics in 34 nearby galaxies, selected from the ALMaQUEST and EDGE-CALIFA surveys. We use 3D-Barolo, a 3D tilted-ring model, to derive the CO and Hα rotation curves. Before comparing rotation curves in the 34 nearby galaxies, we found systematics between the MaNGA and CALIFA data using eight MaNGA-CALIFA overlapping galaxies. We assume the rotation curves based on the MaNGA data are accurate and made the corresponding correction to the CALIFA data. Our result shows that ∼56% (19/34) of our galaxies present slower Hα rotation curves compared to the CO rotation curves, with a median value of 6.5 km s−1. The remaining galaxies (15/34) show consistent CO–Hα rotation velocity within uncertainties. As a result, the Hα rotation may underestimate the total dynamical mass by 6% for a circular velocity of 200 km s−1 (the median value in our sample). Furthermore, the difference in the velocity between the CO and Hα rotational velocity is found to correlate with the difference in velocity dispersion between CO and Hα, suggesting that gas pressure plays a role in the discrepancy in velocity. After incorporating the effect of pressure support due to the turbulent gas motion into our sample, the median value of the difference in the velocities decreases to 1.9 km s−1, which in turn reduces the underestimation of the dynamical mass to ∼2%. Finally, we also investigate the role that the extraplanar diffuse ionized gas plays in the discrepancy in the velocity of CO–Hα.
Reading the CARDs: The Imprint of Accretion History in the Chemical Abundances of the Milky Way's Stellar Halo
Authors: Cunningham Emily C. , Sanderson Robyn E. , Johnston Kathryn V. , Panithanpaisal Nondh , Ness Melissa K. , Wetzel Andrew , Loebman Sarah R. , Escala Ivanna , Horta Danny , Faucher-Giguère Claude-André 
Published: August 2022

Abstract
In the era of large-scale spectroscopic surveys in the Local Group, we can explore using chemical abundances of halo stars to study the star formation and chemical enrichment histories of the dwarf galaxy progenitors of the Milky Way (MW) and M31 stellar halos. In this paper, we investigate using the chemical abundance ratio distributions (CARDs) of seven stellar halos from the Latte suite of FIRE-2 simulations. We attempt to infer galaxies’ assembly histories by modeling the CARDs of the stellar halos of the Latte galaxies as a linear combination of template CARDs from disrupted dwarfs, with different stellar masses M
⋆ and quenching times t
100. We present a method for constructing these templates using present-day dwarf galaxies. For four of the seven Latte halos studied in this work, we recover the mass spectrum of accreted dwarfs to a precision of <10%. For the fraction of mass accreted as a function of t
100, we find the residuals of 20%–30% for five of the seven simulations. We discuss the failure modes of this method, which arise from the diversity of star formation and chemical enrichment histories that dwarf galaxies can take. These failure cases can be robustly identified by the high model residuals. Although the CARDs modeling method does not successfully infer the assembly histories in these cases, the CARDs of these disrupted dwarfs contain signatures of their unusual formation histories. Our results are promising for using CARDs to learn more about the histories of the progenitors of the MW and M31 stellar halos.
The Broad Line Region and Black Hole Mass of NGC 4151
Authors: Bentz Misty C. , Williams Peter R. , Treu Tommaso 
Published: August 2022

Abstract
We present a reanalysis of reverberation mapping data from 2005 for the Seyfert galaxy NGC 4151, supplemented with additional data from the literature to constrain the continuum variations over a significantly longer baseline than the original monitoring program. Modeling of the continuum light curve and the velocity-resolved variations across the Hβ emission line constrains the geometry and kinematics of the broad line region (BLR). The BLR is well described by a very thick disk with similar opening angle (θ

o
≈ 57°) and inclination angle (θ

i
≈ 58°), suggesting that our sight line toward the innermost central engine skims just above the surface of the BLR. The inclination is consistent with constraints from geometric modeling of the narrow-line region, and the similarity between the inclination and opening angles is intriguing given previous studies of NGC 4151 that suggest BLR gas has been observed temporarily eclipsing the X-ray source. The BLR kinematics are dominated by eccentric bound orbits, with ∼10% of the orbits preferring near-circular motions. With the BLR geometry and kinematics constrained, the models provide an independent and direct black hole mass measurement of

log

M

BH

/

M

⊙

=

7.22

−
0.10

+
0.11

or

M

BH

=

1.66

−
0.34

+
0.48

×

10

7

M
⊙, which is in good agreement with mass measurements from stellar dynamical modeling and gas dynamical modeling. NGC 4151 is one of the few nearby broad-lined Seyferts where the black hole mass may be measured via multiple independent techniques, and it provides an important test case for investigating potential systematics that could affect the black hole mass scales used in the local universe and for high-redshift quasars.
Hematology Parameter Based on Tubex TF® Color Scale Result in Typhoid Fever Patients
Authors: Nugraheni Enny , Syahrurachman Agus , Dewi Beti , Nainggolan Leonard , Arodes Evy Suryani , Mulyadi Mulyadi 
Published: August 2022

BACKGROUND: Infection with Salmonella enterica subspecies serovar Typhi and Paratyphi A, B, and C causes typhoid and paratyphoid fever. This is a major source of mortality and morbidity, especially in youngsters. Typhoid fever frequently causes non-specific symptoms. Symptoms that appear obstructively are comparable to those seen in other infectious illnesses and have similar clinical manifestations. Complications can be avoided with early detection and treatment.

AIM: This study will look at the hematology parameter profile to determine whether there are any hematological differences between patients with high and low antibodies.

METHODS: The research was conducted in Bengkulu, Indonesia, in June 2020 until July 2021. Subject collection was done according to inclusion and exclusion criteria. Subjects have given informed consent. The research included a total of 39 subject patients. Demographic data were collected using a questionnaire and 3 mL of blood was taken. Blood was examined for Tubex TF® and hematological examination. Statistical analysis used independent t-test and performed with SPSS.

RESULTS: The research included a total of 39 subject patients. Most were male and most were aged 21–25 years. The most common symptom felt by the subject was gastrointestinal complaints. The analysis was carried out based on the color scale value of the Tubex TF® which was divided into two groups, 4 color scale groups and 6 color scale groups. Hematological parameters of hemoglobin, hematocrit, WBC, platelets, monocytes, lymphocytes, and neutrophils showed no significant difference. However, color scale group 6 showed lower value than 4 color scale group.

CONCLUSION: Hematological indicators in typhoid fever were not substantially changed in Tubex TF®-positive typhoid fever patients. Clinicians can offer the same therapy in instances with typhoid fever, despite having differing positive Tubex TF® scores.
Functional Recognition Theory and Type 2 Immunity: Insights and Uncertainties
Authors: Rahimi Rod A , Sokol Caroline L 
Published: August 2022

Abstract
Type 2 immunity plays an important role in host defense against helminths and toxins while driving allergic diseases. Despite progress in understanding the biology of type 2 immunity, the fundamental mechanisms regulating the type 2 immune module remain unclear. In contrast with structural recognition used by pattern recognition receptors, type 2 immunogens are sensed through their functional properties. Functional recognition theory has arisen as the paradigm for the initiation of type 2 immunity. However, the vast array of structurally unrelated type 2 immunogens makes it challenging to advance our understanding of type 2 immunity. In this article, we review functional recognition theory and organize type 2 immunogens into distinct classes based on how they fit into the concept of functional recognition. Lastly, we discuss areas of uncertainty in functional recognition theory with the goal of providing a framework to further define the logic of type 2 immunity in host protection and immunopathology.
Pneumomediastinum in the COVID-19 era: to drain or not to drain?
Authors: Patel Nian , Nicolae Robert , Geropoulos Georgios , Mandal Pallabhi , Christou Chrysanthos D. , Gavala Marianna , Madouros Nikolaos , Papapanou Michail , Mogal Rahul , Giannis Dimitrios , Kechagias Konstantinos S. , Panagiotopoulos Nikolaos 
Published: August 2022

Pneumomediastinum (PNM) is a rare clinical finding, usually with a benign course, which is managed conservatively in the majority of cases. However, during the COVID-19 pandemic, an increased incidence of PNM has been observed. Several reports of PNM cases in COVID-19 have been reported in the literature and were managed either conservatively or surgically. In this study, we present our institutional experience of COVID-19 associated PNM, propose a management algorithm, and review the current literature. In total, 43 Case Series were identified, including a total of 747 patients, of whom 374/747 (50.1%) were intubated at the time of diagnosis, 168/747 (22.5%) underwent surgical drain insertion at admission, 562/747 (75.2%) received conservative treatment (observation or mechanical ventilation. Inpatient mortality was 51.8% (387/747), while 45.1% of the population recovered and/or was discharged (337/747). In conclusion, with increased incidence of PNM in COVID-19 patients reported in the literature, it is still difficult to assign a true causal relationship between PNM and mortality. We can, however, see that PMN plays an important role in disease prognosis. Due to increased complexity, high mortality, and associated complications, conservative management may not be sufficient, and a surgical approach is needed.
The effectiveness of the pregnancy adapted YEARS algorithm to safely identify patients for CT pulmonary angiogram in pregnant and puerperal patients suspected of having pulmonary embolism
Authors: Potgieter Riaan , Becker Piet , Suleman Farhana 
Published: August 2022

Background: Pulmonary thromboembolism is one of the leading causes of maternal death worldwide. Globally there has been increasing physician reliance on CT pulmonary angiogram for definitive diagnoses and exclusion of pulmonary thromboembolism. The problem, however, arises when considering the high radiation penalty from performing these investigations, highlighted by the low diagnostic yield. Of recent, the pregnancy-adapted YEARS algorithm has shown promise in international studies as a possible alternative for stratifying risk of pulmonary thromboembolism during the pregnancy and puerperal period.Objectives: To determine the effectiveness of the pregnancy adapted YEARS algorithm to safely minimise the number of true negative CT pulmonary angiograms for patients suspected of having pulmonary embolism in our clinical setting.Method: A cross-sectional study was performed in a tertiary hospital in Gauteng on puerperal and pregnant patients suspected of having pulmonary embolism. We retrospectively applied the pregnancy adapted YEARS algorithm and reviewed the various outcomes.Results: The pregnancy adapted YEARS algorithm proved effective in safely identifying patients for CT pulmonary angiography. By retrospectively applying the algorithm, there could have been a 25.7% scan reduction, whilst maintaining a negative predictive value of 100.0%.Conclusion: As physician reliance on radiological investigations increases, we must remain cognisant of the added radiation exposure and the long-term adverse effects of ionising radiation. The pregnancy-adapted YEARS algorithm provides a safe, reproducible alternative to aid our bid going forward.
Predictors of sleepiness in obstructive sleep-apnea syndrome
Authors: Suliman Lucy Abd El-Maaboud , Ali Raed El Metwally , Shehata Mohammed El Desoky Abu , Mohammed El-Shimaa S. 
Published: August 2022

Abstract

Introduction
Excessive daytime sleepiness is a common complaint among patients with obstructive sleep apnea (OSA). On the contrary, OSA has been cited as the most common medical issue linked to excessive daytime sleepiness. In patients with OSA, there is considerable interindividual unpredictability in sleepiness, the determinants of this variability are obscure; also, there is disparity in data correlating subjective with objective sleepiness.

Aim
The aim of this research is to survey the predictors that assess sleepiness in patients newly diagnosed with and how they correlate to the degree of OSA severity.

Patients and methods
A cross-sectional research of 80 patients with recently diagnosed OSA using polysomnography (PSG) (apnea–hypopnea index ≥5/h). Subjective sleepiness was estimated by Epworth Sleep Scale (ESS) (≥10). However, objective sleepiness was determined by Psychomotor Vigilance Test (PVT) (mean lapse ≥2). Participants were also analyzed using the basic language Morningness scale, the STOP-BANG, and Berlin Questionnaires, and the interleukin 6 level was tested.

Results
There were four groups of participants (a: sleepy by ESS and PVT, b: sleepy by PVT only, c: sleepy by ESS only, and d: nonsleepy reference group). Sleepiness was found to be protected by longer habitual sleep duration, morning chronotype, and higher sleep efficacy [P=0.001 and odds ratio (OR)=0.549 and P=0.01 and OR=0.114 and P=0.001 and OR=0.025, respectively]. Sleepiness was attributed with no specific chronotype and a greater arousal index (P=0.043 and OR=9.14 and P=0.002, OR=1.14). In group 1, the level of interleukin 6 was higher.

Conclusion
Sleepiness in OSA was associated with short sleep duration, evening, and no specific chronotype, increased arousal index, and lower sleep efficacy. These findings will help to guide future research into the development of sleepiness in OSA.