bluuebunny/crossref_metadata_2025_split huggingface dataset:
Single and Repeated Doses of EGb 761® do not Affect Pharmacokinetics or Pharmacodynamics of Rivaroxaban in Healthy Subjects
Authors: Hoerr Robert , Zimmermann Andrea , Seitz Friedeborg , Dienel Angelika 
Published: April 2022

The present drug-drug interaction study investigates whether single or repeated doses of 240 mg Ginkgo biloba extract EGb 761® alter the pharmacokinetics or pharmacodynamics of rivaroxaban in healthy subjects. This was a single-centre, two-period, fixed-sequence trial. In Period 1, rivaroxaban was taken alone. In Period 2, rivaroxaban was given on the first and last of 8 days of EGb 761® treatment. Plasma concentrations of rivaroxaban and anti-Factor Xa activity were determined until 48 h after each rivaroxaban intake. The data of forty-one healthy subjects (25 males, 16 females) aged 21–70 years were evaluable. Geometric mean ratios (90% confidence intervals) for rivaroxaban administered concomitantly with a single or multiple doses of EGb 761® vs. rivaroxaban administered alone were 97.97 (91.78, 104.58) and 96.78 (90.67, 103.31) for maximum concentration (Cmax), 98.55 (94.43, 102.84) and 97.82 (93.73, 102.08) for area under the concentration-time curve (AUC0-∞) of rivaroxaban in plasma (primary endpoints), 98.19 (92.00, 104.80) and 99.78 (93.43, 106.55) for maximum effect (Emax), 99.46 (93.63, 105.66) and 99.12 (93.25, 105.35) for area under the effect curve (AUEC0-48). All 90% confidence intervals were within the prespecified range of 80%–125%. Neither adverse events related to haemorrhages nor clinically significant findings in haematology or coagulation parameters were observed. The treatments were safe and well-tolerated. Single and repeated doses of EGb 761® neither affect plasma concentrations of rivaroxaban nor anti-Factor Xa activity in healthy subjects.
Low-Intensity Resistance Exercise Combined With Blood Flow Restriction is More Conducive to Regulate Blood Pressure and Autonomic Nervous System in Hypertension Patients—Compared With High-Intensity and Low-Intensity Resistance Exercise
Authors: Zhao Yan , Zheng Yuchan , Ma Xiaohuan , Qiang Lili , Lin Aicui , Zhou Mo 
Published: April 2022

Background: The effect of resistance exercise on the autonomic nervous system of patients with hypertension has not been identified.Objective: To explore a suitable resistance training method for hypertension patients to regulate blood pressure (BP) and autonomic nervous system function.Method: Forty-five hypertension patients aged between 55 and 70 years were randomly equally divided into three groups: the high-intensity resistance exercise (HE) group, the low-intensity resistance exercise combined with blood flow restriction (LE-BFR) group, and the low-intensity resistance exercise (LE) group. All patients performed quadriceps femoris resistance exercise. The exercise intensity of HE, LE-BFR and LE group was 65, 30 and 30% of one repetition maximum (1RM), respectively. The LE-BFR group used pressure cuffs to provide 130% of systolic pressure to the patient’s thighs during resistance exercise. The training program was 20 times/min/set with a 1-min break after each set, and was conducted five sets/day and 3 days/week, lasting for 12 weeks. The heart rate (HR), BP, root-mean-square of difference-value of adjacent RR intervals (RMSSD), low frequency (LF) and high frequency (HF) were evaluated before and after the first training and the last training.Result: Significant differences in HR were observed in both recovery states after the first and last training (p &lt; 0.01). After 12 weeks of training, the recovery speed of HR in the LE-BFR group increased significantly (p &lt; 0.01). The systolic blood pressures in the HE and LE-BFR group were significantly reduced (p &lt; 0.05 and p &lt; 0.01), and the differences among groups were significant (p &lt; 0.01). In the last recovery state, the RMSSD of the LE group was significantly lower than that in the first recovery state (p &lt; 0.01). The LF/HF ratios of the HE and LE groups in the resting and recovery states were increased significantly (all p &lt; 0.01). LF/HF ratios in the LE-BFR group in the resting and recovery state were decreased significantly (both p &lt; 0.01).Conclusion: Compared to HE and LE, LE-BFR could effectively decrease systolic pressure and regulate the autonomic nervous system function in hypertension patients.
Effect of an Ultra-Endurance Event on Cardiovascular Function and Cognitive Performance in Marathon Runners
Authors: Perrotta Andrew S. , Jeklin Andrew T. , Bredin Shannon S. D. , Shellington Erin M. , Kaufman Kai L. , de Faye Amanda , Miles Rosalin M. , Warburton Darren E. R. 
Published: April 2022

BackgroundUltra-marathon running participation has become increasingly more popular in recent years; however, there is inconclusive evidence concerning the effects of participation on cognition and cardiovascular function. The purpose of this study was to examine alterations in cardiovascular function and cognitive performance and their association in ultra-marathon runners prior to and following an ultra-endurance event.MethodsIn total, 24 runners (19 males and 5 females) participated in an ultra-marathon race (FatDog120) held in British Columbia, Canada. Participants competed in varying races distances [48 km (n = 2), 80 km (n = 7), 113 km (n = 3), and 193 km (n = 12)]. Cognition was assessed prior to and upon race completion using simple reaction time, choice reaction time, discrimination reaction time, and recognition memory (% correct). Cardiovascular function was assessed prior to and upon race completion using radial applanation tonometry for diastolic pulse contour examination.ResultsCognitive performance displayed significantly (p &lt; 0.001) slower reaction times post-race for simple (30.2%), discrimination (22.7%), and choice reaction time (30.5%), as well as a significant (p &lt; 0.05) reduction in memory test performance (−8.2%). A significant association between systemic vascular resistance and choice reaction time was observed post-race (r = 0.41, p &lt; 0.05). Significant changes in post-race cardiovascular function were observed in resting heart rate (31.5%), cardiac output (27.5%), mean arterial blood pressure (−5.6%), total systemic resistance (−17.6%), systolic blood pressure (−7.0%), pulse pressure (−11.2%), and rate pressure product (22.4%). There was evidence of enhanced cardiovascular function being associated with improved cognitive performance before and after the ultra-endurance event.ConclusionUltra endurance running is associated with marked impairments in cognitive performance that are associated (at least in part) with changes in cardiovascular function in healthy adults.
Unexpected Anisotropy of the Electron and Hole Landé g-Factors in Perovskite CH3NH3PbI3 Polycrystalline Films
Authors: Garcia-Arellano Guadalupe , Trippé-Allard Gaëlle , Campos Thomas , Bernardot Frédérick , Legrand Laurent , Garrot Damien , Deleporte Emmanuelle , Testelin Christophe , Chamarro Maria 
Published: April 2022

In this work, we studied, at low temperature, the coherent evolution of the localized electron and hole spins in a polycrystalline film of CH3NH3PbI3 (MAPI) by using a picosecond-photo-induced Faraday rotation technique in an oblique magnetic field. We observed an unexpected anisotropy for the electron and hole spin. We determined the electron and hole Landé factors when the magnetic field was applied in the plane of the film and perpendicular to the exciting light, denoted as transverse ⊥ factors, and when the magnetic field was applied perpendicular to the film and parallel to the exciting light, denoted as parallel ∥ factors. We obtained |ge,⊥|=2.600 ± 0.004, |ge,∥|=1.604 ± 0.033 for the electron and |gh,⊥|=0.406 ± 0.002, |gh,∥|=0.299 ± 0.007 for the hole. Possible origins of this anisotropy are discussed herein.
New Insights into the Genomic Structure of Avena L.: Comparison of the Divergence of A-Genome and One C-Genome Oat Species
Authors: Gnutikov Alexander A. , Nosov Nikolai N. , Loskutov Igor G. , Blinova Elena V. , Shneyer Viktoria S. , Probatova Nina S. , Rodionov Alexander V. 
Published: April 2022

We used next-generation sequencing analysis of the 3′-part of 18S rDNA, ITS1, and a 5′-part of the 5.8S rDNA region to understand genetic variation among seven diploid A-genome Avena species. We used 4–49 accessions per species that represented the As genome (A. atlantica, A. hirtula, and wiestii), Ac genome (A. canariensis), Ad genome (A. damascena), Al genome (A. longiglumis), and Ap genome (A. prostrata). We also took into our analysis one C-genome species, A. clauda, which previously was found to be related to A-genome species. The sequences of 169 accessions revealed 156 haplotypes of which seven haplotypes were shared by two to five species. We found 16 ribotypes that consisted of a unique sequence with a characteristic pattern of single nucleotide polymorphisms and deletions. The number of ribotypes per species varied from one in A. longiglumis to four in A. wiestii. Although most ribotypes were species-specific, we found two ribotypes shared by three species (one for A. damascena, A. hirtula, and A. wiestii, and the second for A. longiglumis, A. atlantica, and A. wiestii), and a third ribotype shared between A. atlantica and A. wiestii. A characteristic feature of the A. clauda ribotype, a diploid C-genome species, is that two different families of ribotypes have been found in this species. Some of these ribotypes are characteristic of Cc-genome species, whereas others are closely related to As-genome ribotypes. This means that A. clauda can be a hybrid between As- and C-genome oats.
PUBLIC SPEAKING FOR PUBLIC LIFE
Authors: Tawami Tatan , Zahratunnisa Zainab , Fadhila Naura 
Published: April 2022

Tujuan dari kegiatan Pengabdian pada Masyarakat yang berjudul Public Speaking for Public Life adalah untuk meningkatkan kesadaran akan pentingnya softskills (social skills), terutama bagi para mahasiswa atau pembelajar dalam aktifitas keseharian mereka. Penelitian ini memaparkan keterampilan-keterampilan sosial apa yang dibutuhkan untuk meningkatkan kualitas interaksi pembelajar di masyarakat serta untuk meningkatkan rasa percaya diri pembelajar. Metode pelaksanaan kegiatan ini adalah melalui diskusi interaktif secara daring pada tanggal 24 April 2021. Diskusi ini dihadiri oleh berbagai peserta; mahasiswa Sastra Inggris Unikom, Perwakilan AIYA West Java Chapter, dan peserta umum. Hasil dari diskusi ini kemudian dipaparkan secara kualitatif dan sistematis dalam penulisan artikel ini. Hasil diskusi memperlihatkan adanya peningkatan keawasaan peserta diskusi terkait dengan keterampilan sosial yang dibutuhkan dalam berinteraksi. Keterampilan sosial yang disoroti pada bagian diskusi dan interaksi adalah rasa percaya diri, berpengetahuan, dan berempati. Ketiga keterampilan sosial tersebut dapat dikatakan sebagai keterampilan dasar dalam berinteraksi dengan orang lain karena dapat memotivasi pembelajar untuk berbicara dengan pengetahuan yang memadai dan pada saat yang sama memahami apa yang dibutuhkan/tidak dibutuhkan dalam suatu interaksi sosial. Berdasarkan hasil diskusi, dapat disimpulkan bahwa belajar public speaking bermanfaat untuk meningkatkan tidak hanya nilai diri sendiri namun juga interaksi sosial di masyarakat.
Kata kunci: Rasa Percaya Diri, Berempati, Public Speaking, Berpengetahuan, dan Keterampilan
Pengembangan Business Model Canvas bagi Usaha Kecil Triple 3 Music Bandung
Authors: Iffan Muhammad 
Published: April 2022

In the current digital era, business actors need new strategies to survive in business competition, one of which is by following the development of e-commerce in order to expand the market. Triple 3 Music Bandung is a small business engaged in selling musical instruments and podcasts. The aim of this article was to convey understanding to Triple 3 Music Bandung and other parties about the business development. The method chosen in this Community Service activity was to conduct interviews with the owner of Triple 3 Music Bandung and make observations on these businesses in order to determine business development strategies using Business Model Canvas analysis. The result of this activity is the proposed of a new strategy that can be implemented in the development of the Triple 3 Music Bandung business based on the nine elements in the Business Model Canvas. The business strategy that has been implemented by the business owner of Triple 3 Music Bandung is quite good, however, it is necessary to develop a business strategy to maximize potential. It is hoped that with the new business strategy, Triple 3 Music Bandung can strengthen its market position and can increase its competitive advantage in competition with similar businesses so as to improve business performance.
Keywords: Business Model Canvas, Small Enterprise
Os caminhos da formação e da pesquisa, tecendo uma trajetória
Authors: Amorim Wagner Vinicius , Alves Teles Glauciana 
Published: April 2022

O que nasceu como uma tentativa de aproximar pesquisadores de diversas áreas, de mobilizar os membros do Conselho Editorial da SertãoCult na elaboração de um material que exprimisse a capacidade da editora em produzir obras com qualidade técnica e com relevância acadêmica, tornou-se um sucesso logo em sua primeira edição. Após o lançamento do volume Diálogos sobre a Ditadura, que reuniu alguns dos maiores pesquisadores sobre a temática no Brasil, a série Território Científico chega ao seu segundo volume elaborado a partir de uma parceria com os profissionais ligados ao Seminário da Rede de Pesquisadores sobre as Cidades Médias (ReCiMe). Eis a obra “Trajetórias de pesquisadores e os estudos das cidades médias em perspectiva”. É gratificante concluirmos mais esta contribuição para a comunidade científica, apresentando as trajetórias de algumas das maiores referências da Geografia Urbana brasileira, que no contexto da pandemia da Covid-19 ficaram tão fisicamente distantes, mas nunca tão próximos, unidos através da tecnologia, que permitiu a troca de experiências com colegas de diferentes regiões do país. Passados alguns meses da realização das entrevistas, finalmente a pandemia dá mostras de arrefecimento. O isolamento que tanto nos custou, começa a dar lugar a reencontros presenciais e estas entrevistas, mais do que um relato de experiências de pesquisa, passam a compor um registro histórico de como a crise sanitária afetou toda a nossa sociedade. Se a produção científica segue sendo alvo de constantes ataques e aqueles que se dedicam a ela ainda são encarados quase como inimigos do Estado, é mais do que pertinente, mas necessário que todos aqueles que acreditam na educação, na ciência, no conhecimento se unam e abracem projetos que busquem aproximar essa produção e o público em geral. Mais um livro se junta à nossa série, nos deixando ainda mais orgulhosos e empenhados em nossa defesa incondicional da ciência. Que venham os próximos volumes!
Respons kambing yang diberi pellet pakan lokal teramoniasi dan suplementasi Urea Gula Aren Blok (UGB)
Authors: Kaunang Ch L. , Pudjihastuti E 
Published: April 2022

Tujuan penelitian ini adalah untuk melihat pengaruh pemberian pellet pakan hijauan lokal (B.mutica) teramoniasi dan suplementasi UGB terhadap produktivitivitas ternak. Penelitian ini dilaksanakan selama 8 bulan. Ternak yang digunakan terdiri dari 30 ekor kambing jantan lokal, berumur 9 bulan dengan berat badan berkisar 20-25 kg. Ransum perlakuan terdiri dari: R0 = Konsentrat (1% dari bobot badan) + rumput B.mutica teramoniasi (100%) + 300 gram UGB (kontrol), R1= Pellet dari campuran konsentrat (1% dari bobot badan) dan rumput B.mutica teramoniasi (100%)+300 g UGB. Data yang diperoleh dianalisis dengan menggunakan t-test. Parameter yang diamati adalah konsumsi bahan kering, pertambahan bobot badan harian, dan status metabolis darah. Rataan konsumsi bahan kering pakan dalam penelitian ini berkisar 405 – 650 g/ekor/hari. Hasil penelitian ini menunjukkan bahwa menunjukkan bahwa perlakuan R1 sangat nyata lebih tinggi dari perlakuan R0. Rataan PBBH dalam penelitian ini berkisar 90,20-110,40 g/ekor/hari. Hasil penelitian menunjukkan bahwa menunjukkan bahwa perlakuan R1 sangat nyata lebih tinggi dari perlakuan R0. Rataan kadar Ca darah dalam penelitian ini berkisar 9,9-10,1 mg/dL rataan kandungan P darah dalam penelitian ini berkisar 6,3-8,1 mg/dL, rataan kandungan Na dalam darah pada penelitian ini berkisar 102-149 149 mmol/L, rataan kandungan Mg dalam darah pada penelitian ini berkisar 4.4 mg/dL-5.9 mg/dL dan rataan kandungan Cl darah dalam penelitian ini berkisar 100 mmol/L -121 mmol/L. Hasil analisis statistik menunjukkan bahwa perlakuan tidak memberikan pengaruh yang nyata terhadap kandungan Ca, P, Na, Ca, Mg, dan Cl dalam darah. Namun demikian semua nilai parameter status metabolis darah dalam penelitian ini menunjukkan kecenderungan meningkat akibat perlakuan. Dari penelitian ini dapat disimpulkan bahwa pemberian pakan pellet campuran konsentrat (1% dari bobot badan) dan rumput B.mutica teramoniasi (100%) + 300 g UGB memberikan respons yang optimal terhadap konsumsi bahan kering, pertambahan bobot badan harian dan status metabolis darah ternak kambing.Kata kunci : Pellet, B.mutica, Amoniasi, UGB, Kambing.
Prevalensi infeksi parasit cacing Ascaris suum pada usus halus babi di tempat penampungan Desa Motoling, Minahasa Selatan
Authors: Tiwa A.J. , Podung A.J. , Pudjihastuti E. , Assa G.V.J. , Paath J.F. 
Published: April 2022

Penelitian ini bertujuan mengukur prevalensi infeksi parasit cacing pada usus halus ternak babi di lokasi penampungan dan pemotongan Desa Motoling, Minahasa Selatan. Penelitian ini menggunakan sampel 50 ekor ternak babi yang dipotong dan diambil usus halusnya dan diamati parasit cacing serta diukur prevalensinya berdasarkan ras ternak, jenis kelamin dan umur ternak. Metode penelitian yang digunakan yaitu ekplorasi deskriptif. Ternak babi yang ditampung dan dipotong selain berasal dari daerah sekitar tempat penampungan, juga berasal dari luar daerah, seperti Minahasa, Kotamobagu dan Palu. Berdasarkan hasil identifikasi parasit cacing dan pengamatan yang diperoleh pada penelitian ini, didapatkan cacing Ascaris suum. Prevalensi parasit Ascaris suum ditemukan dari sampel sebesar 12%, Infeksi parasit Ascaris suum hanya didapatkan pada babi ras jenis Landrace dengan prevalensi 16,2%. Berdasarkan jenis kelamin ternak, prevalensi parasit cacing lebih tinggi pada ternak jantan 21,1%, sedangkan ternak betina prevalensi 6,5%. Berdasarkan umur, didapati tingkat infeksi tertinggi pada kelompok umur ternak 6-7 bulan dengan prevalensi 19,2%, umur 7 – 8 bulan prevalensi sebesar 5,0%. Kesimpulannya teridentifikasi cacing dewasa Ascaris suum menginfeksi usus halus ternak babi di tempat penampungan babi siap potong di Desa Motoling. Prevalensi infeksi lebih tinggi pada kelompok babi ras landrace dibandingkan Duroc dan babi lokal. Berdasarkan jenis kelamin ternak, prevalensi infeksi A. suum lebih tinggi pada babi jantan dibandingkan betina. Berdasarkan umur babi, prevalensi infeksi A. suum lebih tinggi pada babi umur 6-7 bulan dibandingkan babi diatas umur 7 dan 8 bulan.Kata Kunci : , Ternak babi , usus halus , Ascaris suum
Analisis perbedaan perilaku konsumen dalam pembelian daging ayam ras pada pasar Tradisional dan Modern di kota Manado
Authors: Utiah M P , Kalangi J. K.J , Oroh F. N.S 
Published: April 2022

Penelitian ini bertujuan untuk menganalisis perbedaan perilaku konsumen yang membeli daging ayam ras pada Pasar tradisional dan pasar modern di kota Manado. Penelitian ini dilakukan menggunakan metode survey dengan berpedoman pada kuesioner. Lokasi penelitian di tentukan secara purposive pada pasar bersehati dan Jumbo swalayan masing masing mewakili pasar tradisional dan pasar modern. Penentuan sampel menggunakan teknik Accidental Sampling. Hasil penelitian menunjukkan bahwa faktor-faktor yang mempengaruhi perilaku konsumen dalam pembelian daging ayam ras adalah faktor Karakteristik konsumen yang meliputi variabel umur, pendidikan, pekerjaan, dan pendapatan, faktor produk yang meliputi variabel lokasi, promosi, dan kualitas, serta faktor harga yang meliputi variabel harga. Hasil penelitian menunjukkan terdapat perbedaan yang signifikan antara perilaku konsumen yang berbelanja daging ayam ras di Pasar tradisional dan Pasar modern di Kota Manado (P<0,05).
Analisis faktor konsentrat pakan komersil berbeda terhadap sifat-sifat produksi ayam ras petelur
Authors: Utiah W. , Paputungan U. , Tangkau L.M.S. 
Published: April 2022

Pada masa ini banyak tersedia berbagai jenis ransum komersial (konsentrat) untuk ayam petelur yang diproduksi oleh perusahaan pakan ternak, dimana komposisi zat-zat makanannya telah tercantum sehingga nilai nutrisi pakan yang disusun dapat dihitung kadarnya. Tujuan penelitian ini untuk mengetahui apakah ada pengaruh pemberian jenis konsentrat komersil yang berbeda terhadap konsumsi ransum, rasio efisensi penggunaan ransum, Hen Day Egg Production (HDEP) dan Berat Telur. Penelitian ini dilaksanakan pada peternakan ayam ras petelur yeng terletak di Kelurahan Matali Kecamatan Kotamobagu Timur Kota Kotamobagu. Ayam petelur yang digunakan adalah Strain Silver sebanyak 240 ekor berumur 78 minggu. Penelitian ini menggunakan Rancangan acak Lengkap (RAL) yang terdiri dari 3 perlakuan dan 8 ulangan. Rancangan ini digunakan untuk menganalisis pengaruh perlakuan tiga jenis konsentrat komersil terhadap konsumsi ransum, rasio efisensi penggunaan ransum, Hend Day Ggg Production (HDEP) dan Berat telur, yaitu Konsentrat komersil A (RA), Konsentrat komersil B (RB) dan Konsentrat komersil C (RC). Hasil penelitian menunjukkan bahwa untuk konsumsi ransum, rasio efisiensi ransum, Hen Day Egg Production dan berat telur untuk Konsentrat komersil A (RA), Konsentrat komersil B (RB) dan Konsentrat komersil C (RC) menunjukkan berbeda tidak nyata. Hal ini disebabkan karena komposisi zat-zat makanan dan asam-asam amino dalam ransum sesuai dengan kebutuhan ayam petelur. Dengan pengertian bahwa konsentrat komersil yang digunakan dalam penelitian ini (RA, RB dan RC) mempunyai kualitas yang hampir sama. Dari penelitian ini dapat disimpulkan bahwa Konsentrat komersil walaupun dari produsen yang berbeda memiliki kandungan zat-zat makanan yang lengkap dan seimbang.Kata Kunci: Konsentrat komersil, ayam ras petelur, konsumsi ransum, berat telur