bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association of Life’s Essential 8 and Life’s Simple 7 with metabolic-associated fatty liver disease in the United States
Authors: Fu Wei , Cheng Guo-Bin , Zhao Jun-Long , Lv Lin-Ya , Ding Yao 
Published: February 2025

BACKGROUND
Cardiovascular health (CVH) plays a crucial role in overall health, but its association with metabolic-associated fatty liver disease (MAFLD) remains unclear.
AIM
To investigate the relationship between CVH, measured using Life’s Essential 8 (LE8) and Life’s Simple 7 (LS7), and the prevalence of MAFLD.
METHODS
This cross-sectional study had a sample of 2234 individuals, representing approximately 120 million individuals in the United States. Baseline parameters were compared between the LE8 and LS7 groups. Logistic regression models were used to evaluate the relationship between LE8, LS7, and MAFLD, while taking into account confounding factors. The investigation employed restricted cubic splines to investigate non-linear associations. Subgroup analyses and sensitivity studies were performed to evaluate the strength and reliability of the results.
RESULTS
Higher LE8 and LS7 scores were significantly associated with a decreased risk of MAFLD, even after controlling for demographic, socioeconomic, and clinical variables. This association demonstrated a non-linear pattern, with the most dramatic risk reduction observed at higher CVH levels. Individual CVH components, notably healthy behaviors and factors, exhibited strong relationships with MAFLD. Subgroup analyses indicated consistent relationships across several demographics. Sensitivity tests utilizing other MAFLD definitions validated the robustness of the findings.
CONCLUSION
Higher adherence to CVH criteria, as indicated by LE8 and LS7 scores, is associated with a significantly lower risk of MAFLD. These results emphasize the need to advance CVH to control and avoid MAFLD.
Survival of patients with hepatopulmonary syndrome related to cirrhotic and non-cirrhotic (schistosomiasis) portal hypertension
Authors: Rolim Melissa M , Farsoun Liana G , Luna Carlos F , Markman-Filho Brivaldo , Querette Paulo , Lopes Edmundo P , Domingues Ana L 
Published: February 2025

BACKGROUND
The hepatosplenic schistosomiasis (HSS) with portal hypertension can cause vascular complications such as hepatopulmonary syndrome (HPS). HPS increases the risk of mortality in patients with cirrhosis; however, there is no data on the mortality of patients with HSS and HPS.
AIM
To perform a survival analysis of patients with HPS related to cirrhotic and non-cirrhotic (schistosomiasis) portal hypertension.
METHODS
From August 2023 to January 2024, medical records and the official mortality information service of 121 patients who participated in a cross-sectional study on HPS between 2010 and 2012 were analyzed. Survival curves were created using the Kaplan-Meier method, and comparisons were performed using the log-rank test. Cox regression models estimated the hazard ratios (HR).
RESULTS
Overall, data of 113 patients were analyzed; most (55.8%) had HSS and concomitant cirrhosis (HSS/cirrhosis). Meanwhile, HPS was present in 39 (34.5%) patients. Death occurred in 65 patients [57.5%; 95% confidence interval (CI): 48%-67%. The average time to death was lower in those with HPS when compared to those without HPS (3.37 years vs 5.65 years; P = 0.017). According to the cause of liver disease, patients with HSS/cirrhosis died earlier, and their risk of death was twice as high compared with patients with HSS without cirrhosis (HR: 2.17; 95%CI: 1.3-3.60; P = 0.003). Meanwhile, there were no differences when comparing the two groups with and without HPS (HR: 1.01; 95%CI: 0.59-1.73; P = 0.967).
CONCLUSION
Patients with HSS and concomitant cirrhosis had a lower survival rate, but there was no difference in survival regardless of the presence of HPS.
Hepatitis B virus confers innate immunity evasion through hepatitis B virus-miR-3 down-regulation of cGAS-Sting-IFN signaling
Authors: Xu Zhen-Yu , Gao Jia-Shi , He Ying , Xiao Xin-Qiang , Gong Guo-Zhong , Zhang Min 
Published: February 2025

BACKGROUND
Hepatitis B virus (HBV) evades the innate immunity and leads to persistent chronic infection, but the molecular mechanism is still not well known.
AIM
To investigate whether HBV-miR-3 is involved in HBV immune evasion.
METHODS
HBV-miR-3 agomir and antagomir were employed to verify the effectiveness of HBV-miR-3 on cGAS-Sting-IFN pathway through the experiments on relative luciferase activity, cGAS protein expression, Sting phosphorylation and interferon (IFN) production.
RESULTS
HBV-miR-3 down-regulates cGAS protein expression post-transcriptionally by inhibition of cGAS 3’-untranslated region (3’-UTR) activity, which results in lower Sting phosphorylation and IFN production. HBV-miR-3 antagomir rescued cGAS protein expression, Sting phosphorylation and IFN-β production.
CONCLUSION
HBV-miR-3 plays an important role in HBV immunity evasion by targeting cGAS 3’-UTR and interfering with cGAS-Sting-IFN pathway.
<i>In Vivo</i> Antidiarrhoeal Activity and Molecular Docking Studies of a Coumarin Isolated from the Root Extract of <i>Impatiens ethiopica</i> Grey-Wilson
Authors: Yimer Sileshi , Yeshak Mariamawit Y. , Tadesse Solomon , Asres Kaleab , Bisrat Daniel 
Published: February 2025

Impatiens ethiopica Grey-Wilson has been traditionally used in the treatment of infectious diseases. This study aimed to evaluate the antidiarrhoeal potential of I. ethiopica root extract and its major constituent. The investigation employed in vivo models, including castor oil-induced diarrhoeal model, antienteropooling test, and charcoal meal test in mice. The 80% methanol extract of I. ethiopica significantly reduced the frequency of defecation, faecal weight, and diarrhoea onset at administered doses of 100, 200, and 400 mg/kg. The active root extract was sequentially separated into four fractions based on solubility using petroleum ether, chloroform, methanol, and water. Further fractionation of the methanol fraction via column chromatography yielded scopoletin (7-hydroxy-6- methoxycoumarin), confirmed through spectroscopic analysis. Scopoletin also exhibited significant antidiarrhoeal activity by reducing intestinal fluid accumulation and gastrointestinal (GI) motility at doses of 10, 20, and 40 mg/kg. Scopoletin is suggested to act on prostaglandin synthase (PGS, COX-2; PDB ID: 4COX), showing a promising docking score of −7.941 kcal/mol. It exhibits a strong binding affinity, forming hydrogen bonds with SER530 and engaging in - stacking interactions with TYR385 and TRP387 at specific COX-2 binding sites. These findings highlight that the antidiarrhoeal activity of I. ethiopica was attributed to the presence of scopoletin. Overall, these results uphold the traditional use of I. ethiopica roots in the treatment of diarrhoea and highlight the potential of scopoletin as antidiarrhoeal compound.
Grocery Shopping and Eating Behaviors Differ Between Persons With and Without a Spinal Cord Injury
Authors: Donato Zachary J. , Levy Adam S. , Sneij Alicia , LaVela Sherri L. , Berg Arthur S. , Shapiro Lauren T. , Farkas Gary J. 
Published: February 2025

Background:
Spinal cord injury (SCI) heightens the susceptibility to neurogenic obesity, which is driven by alterations in energy metabolism and suboptimal dietary habits after injury. Those with SCI may adjust their grocery shopping and eating behaviors, notably influencing overall health outcomes.

Objectives:
To assess differences in grocery shopping and eating behaviors between persons with and without (controls) SCI.

Methods:
In an online, cross-sectional study, adults with (n = 207) and without (n = 52) SCI completed a one-time survey that assessed grocery shopping behavior (shopping frequency and who completed the shopping) and eating behaviors, including the frequency of consuming alcoholic beverages, fast food, and preferences for fried food. Regression analyses were employed for group comparisons, controlling for relevant measures.

Results:
Compared to the controls, a smaller proportion of persons with SCI grocery shopped independently in person (P = .002), and a greater proportion relied on others to fulfill grocery needs (P = .008). Individuals with SCI demonstrated a reduced monthly frequency of overall (P = .019) and independent in-person grocery shopping than controls (P = .014). In contrast, the monthly frequency of grocery shopping through delivery and from their caregivers was similar (P &gt; .05). Fried food and fast-food intake were comparable (P &gt; .05), whereas alcoholic beverage consumption was lower in individuals with SCI than controls (P = .006).

Conclusion:
People with SCI reported obtaining groceries less often than controls, and a greater proportion relied on others, rather than themselves, to fulfill grocery needs. These findings highlight the influence of SCI on biobehavioral activities affecting neurogenic obesity, suggesting potential targets for interventions to enhance health outcomes post-SCI.
The Effect of a Low-Glycemic Index Diet on Postprandial Hypotension in Individuals With Chronic Spinal Cord Injury: Results From a Pilot Study
Authors: Farrow Matthew , Li Jia , Chahande Sana , Minarsch Raquel , Orchard Tonya , Schwab Jan , Yarar-Fisher Ceren 
Published: February 2025

Background:
One in two individuals with spinal cord injury (SCI) experiences postprandial hypotension (PPH), a decline (&gt;20 mm Hg) in systolic blood pressure (SBP) within 2 hours after eating. Consuming meals with a low glycemic index (GI) could prevent or lessen PPH.

Objectives:
To determine the effect of a low-GI diet on PPH and postprandial glucose and insulin in individuals with chronic SCI (&gt;1 year postinjury).

Methods:
Eleven participants (6 males, 5 females; age 43 ± 11 years) with chronic SCI (C4-C7, 7; T4-T12, 4) took part in a randomized crossover study (low GI vs. high GI). On each occasion, BP, glucose, and insulin were measured in the fasted state and for 2 hours after consuming a breakfast meal (60% carbohydrate, 28% fat, 12% protein) in laboratory-controlled conditions. Participants wore an ambulatory BP monitor and continuous glucose monitor for 3 days at home, and consumed study meals that were macronutrient-matched across conditions.

Results:
The maximum decrease in systolic blood pressure (SBP) following the laboratory-controlled breakfast meals tended to be lower in the low-GI (14 ± 12 mm Hg) compared to the high-GI (24 ± 25 mm Hg) diet (d = 0.52, P = .056). Serum glucose (P &lt; .01) and insulin (P = .026) concentrations were lower at 30 minutes in the low-GI diet. In the home setting, peak glucose concentrations were lower after lunch (P = .011) and dinner (P &lt; .01) in the low-GI diet.

Conclusion:
A low-GI meal may be an effective solution to reduce the magnitude of PPH and peak glucose concentrations in individuals with chronic SCI.
Comparação da capacidade de selamento de três materiais restauradores provisórios
Authors: GIL ANDERSON CARLOS , NAKAMURA VÍTOR CÉSAR , LOPES RAFAEL PAIVA , LEMOS ÉRICO DE MELLO , CALDEIRA CELSO LUIZ 
Published: February 2025

O objetivo deste trabalho foi avaliar in vitro com auxílio decorante a infiltração marginal em cavidades preenchidas com trêsdiferentes materiais seladores provisórios: Bioplic®, Coltosol® e Provi®.Foram utilizados 36 dentes humanos extraídos unirradiculares. Após acirurgia de acesso, os espécimes foram divididos aleatoriamente em cincogrupos de acordo com o material restaurador provisório, sendo trêsgrupos de estudo e dois grupos controle (G1= Coltosol®; G2= Bioplic®;G3= Provi®, G4 e G5+ controles) Ao final os espécimes foram imersosem solução de azul de metileno. Os resultados mostraram que o Bioplic®apresentou os maiores valores de infiltração, seguido pelo Coltosol® eProvi®, nesta ordem. O grupo de dentes selados com Provi® apresentouuma diminuição significativa no score quando comparado com oBioplic®, sendo que não foram observadas diferenças entre estesmateriais e o Coltosol®. Diante dos resultados obtidos pode-se concluir que o material restaurador provisório que melhor promoveu selamentomarginal foi o Provi®
Estudo epidemiológico das fissuras labiopalatinas na Bahia
Authors: DE FREITAS MARIA DA CONCEIÇÃO ANDRADE , BATISTA TIAGO SANTOS , PEREIRA MÔNICA CILER GOMES , BRANDÃO MARIANNA MENDONÇA , MARIANETTI LÍVIA VAZ SAMPAIO , DE ALMEIDA PAULO PLESSIN 
Published: February 2025

As fissuras labiopalatinas atingem a face média pela rupturado lábio e/ou palato. São reconhecidas pela Organização Mundial deSaúde como um relevante problema de saúde pública. Objetivo:Descrever os casos de fissuras labiopalatinas ocorridos na Bahia, quantoo gênero, tipo de fissura, síndromes associadas, etnia e localizaçãogeográfica. Metodologia: Os dados foram retirados dos prontuários doCentro de Anomalias Craniofaciais das Obras Sociais Irmã Dulce entre2000 e 2010. Resultados: Dos 1752 pacientes analisados, 52,3% eram dogênero masculino e 47,7% feminino, sem diferença estatisticamentesignificativa. A fissura transforame incisivo teve a maior prevalência(47,3%), sendo o lado esquerdo o mais afetado. Houve predominância de53% nas fissuras unilaterais. Da amostra total, 1,1% estavam relacionadasa síndromes. A de Pierre Robin foi a mais prevalente e todo os casosestavam associados a fissura pós-forame incompleta. Quanto à etnia, asmaiores taxas foram negra (30%) e parda (23,7%). A maioria dos casosregistrados reside nos municípios do interior da Bahia. Conclusão: Estesresultados fornecem instrumentos epidemiológicos para que os gestores de saúde pública estabeleçam protocolos de prevenção e tratamentointerdisciplinar para anomalias craniofaciais.
AVALIAÇÃO DA PADRONIZAÇÃO DE PREPARAÇÕES ALIMENTÍCIAS EM UMA UNIDADE DE ALIMENTAÇÃO E NUTRIÇÃO HOSPITALAR
Authors: ALEXANDRE LUCIANE DE PAULA , PAGAMUNICI LILIAN MARIA , RUIZ SUELEN PEREIRA , MARDIGAN LAURA PAULINO 
Published: February 2025

A utilização de fichas técnicas no preparo de alimentosassegura que refeições servidas em unidades de alimentação e nutrição(UAN) sejam padronizadas nos aspectos sensoriais e nutricionais.Métodos aleatórios resultam em alimentos com excesso de sódio egordura, contribuindo para ocorrência de doenças crônicas nãotransmissíveis (DCNT). Os objetivos do trabalho foram avaliar apadronização de preparações alimentícias em UAN Hospitalar e verificara satisfação dos comensais em relação aos cardápios. Foram investigadosos métodos de produção dos alimentos, por meio de observação eentrevista com 12 cozinheiros. A satisfação dos comensais foi avaliadacom questionários, aplicados no horário de almoço, uma vez por semana,durante 2 meses. Constatou-se que 66,67% dos cozinheiros não sãoesclarecidos sobre a importância da padronização das preparaçõesalimentares; 33,34% não seguem o cardápio padrão; 83,37% não utilizammedidores para adição de ingredientes e usam temperos industrializados.Dos comensais avaliados, 36,25% sentem desconforto abdominal e47,50% sede excessiva após as refeições; 52,50% relataram cardápiosrepetitivos e 47,50% muito calóricos. Conclui-se que na UAN avaliada,não há padronização nas preparações alimentícias, portanto os alimentos oferecidos aos comensais e pacientes podem veicular altas quantidades desódio, gorduras, favorecendo ao surgimento de DCNT.
PENGARUH LINGKUNGAN KERJA TERHADAP KINERJA KARYAWAN PADA PENGECER WARALABA INDOMARET WILAYAH KOTA BANDUNG
Authors: Her Susilo Maulkre , Seprhianti Zhena 
Published: February 2025

Background : Performance is the result of work in terms of quality and quantity achieved by an employee in carrying out his duties in accordance with the responsibilities given to him. Of the several factors that influence performance, one of them is the working environment. Working environments are a place where there are a number of groups where there are several supporting facilities to achieve company goals in accordance with the company's vision and mission. Working environment that are not conducive will hinder target achievement and potentially threaten business continuity. Research objectives : This study investigates the impact of the working environment on employee performance at Indomaret Fresh, Bandung City. Novelty : This research offers novelty by using a sample of Indomaret employees of the Indomaret Fresh type who work in a shop environment that provides the most complete daily necessities compared to minimarkets or other types of Indomaret. Research methodology : This research uses a Single Cross-Sectional Design. The sampling technique chose purposive sampling and used the method of determining saturated samples. Primary data was obtained from collecting Indomaret Fresh employee questionnaires from four locations totaling 60 respondents. Findings : In the analysis, the regression equation Y = 32,971+0.563X was obtained, and the correlation value was 0.662 or strong with a determination of 42.9%. The hypothesis test that the significance obtained is 0.000 < 0.05, thus there is a strong and significant influence between the working environment on employee performance. Conclusion: There is a relationship that can be said to be strong between a working environment and employee performance, and there is quite a significant influence between a working environment and employee performance. By increasing a good working environment, employee performance at Indomaret Fresh will further improve and the better the working environment which is also balanced by increasing HR capabilities, the target achievement will be achieved.
Tourism Experience Architecture to Achieve The SDGs (A Study at Cangkuang Temple Tourism Area)
Authors: Robiansyah Anton , Nuswantara Dian Anita 
Published: February 2025

Objective: This study aims to develop an experience-based tourism development model (experiencescapes) that balances the economic, education and environmental aspects of natural and historical attractions in Cangkuang Temple.

Theoretical Framework: This study explores the intersection of Sustainable Development Goals (SDGs) 4, 8, and 13, in the context of tourism management and destination development.

Method: This study uses a mixed approach, combining qualitative and quantitative methods. Qualitative data were obtained through observations, interviews, and focus group discussions (FGD) with tourism managers and experts, while quantitative data were collected by distributing questionnaires to 50 visitors to measure the quality of the tourism experience.

Results and Discussion: The results show that all dimensions of the tourism experience quality at natural and historical tourist attractions are important for enhancing visitor experiences. Based on these findings, physical designs of the tourism area, such as gazebos, gardens, and museums, are proposed to improve comfort and visitor experience while maintaining the cultural and natural characteristics of the location.

Research Implications: This research provides valuable insights into the factors influencing the quality of the tourism experience and can be used to design more effective and sustainable tourism areas. The findings are expected to help tourism managers enhance the appeal of natural and historical attractions and contribute to the development of more inclusive and educational tourism.

Originality/Value: This study adds value by combining visitors' experience perspectives on natural and historical tourist attractions with the physical design of tourism areas to improve the quality of those experiences. The findings also introduce the concept of "experiencescapes" in designing deeper and more meaningful tourism experiences for visitors.
Effect of Innovative Glassy House and Secondary Reflectors Combination with Nanocoating on Fast and Slow Increase of Receiver Temperature in Parabolic Solar Collector
Authors: Mohammed Ajmi Abd  , Alaa Y. Ali  
Published: February 2025

The purpose of this work is to enhance the ability of the receiver for increasing in temperature absorbing, firstly achieving a rapid rise the temperature in a relatively short time through geometric variables, and secondly, achieving higher temperatures and maintaining them over time for long periods using nano-coatings.The present study related to the development of parabolic dish solar concentrator as a design by using the concept of a glass house with an attempt to invent and manufacture small-sized secondary reflectors to be placed inside the greenhouse which is placed on the side of the receiver at an angle of 45° to reflect the rays that may pass directly without passing through the receiver. The three primary modifications include, copper receiver, a glassy spherical cover, and secondary reflectors. A copper tube is made up of coil in spiral shape and it is fixed in the focus of dish to obtain maximum solar energy. The higher absorber temperature was 58°C with out any modification.The absorber temperature increased with first modification to( 87°C,50%), by using second modification (a glassy spherical ) it was found that the glass cover improved the rapid and greater temperature rise which increased to (132°C, 137%), Also by using of a glassy spherical cover with secondary reflectors (third modification), the increasing absorber temperature are raised to (162°C ,179%). The temperature of the receiver will be less lost with an increase in wind speed in the second and third modifications.Thirdly, a nanocoating was used for each of (CuO, TiO2) to determine the extent to which it is possible to achieve an increase in the absorbed temperature for a relatively long time without any modification once which increased to (71°C,22.4% for CuO nanocoating) and decreased to (50C, -60% for TiO2 nanocoating). Using the third modification with nanocoating and for a relatively long period time, this research found that the temperature increased (175°C,201 % for CuO nanocoating), and ( 115 C, 98% for TiO2 nanocoating).This means that the nanocoating of (TiO2) without an air-tight cover leads to a decrease in the absorption efficiency compared to the absorbing surface alone, but it increases with the use of the third modification, while the coating with (CuO) increases the absorbed temperature in both cases and is more efficient than titanium oxide, the higher temperature difference of the nanocoating is due to higher thermal conductivity of CuO nanoparticles.These results can enhance the improvement of designs used for the same purpose in the future.
Reimaging the Magdalene
Authors: Jolley Siobhán 
Published: February 2025

This book offers a new, intersectional feminist approach to utilising and interpreting the visual reception of Mary Magdalene.Through employment of Liberative Reception Criticism, which develops traditional reception theory in line with liberative hermeneutics, via the insights of intersectionality as critical theory, Siobhan Jolley provides a novel means of analysing how women, and particularly the Magdalene, are imaged in Christian tradition.
Knowledge of both the biblical figure of Mary Magdalene and her cultural reception continue to be dominated by long-discredited ideas about her life and sexuality, which bear the hallmarks of their development under patriarchy. Through close study of relevant biblical texts and extracanonical accounts, and a comprehensive survey of the Magdalene’s presentation in the Italian art of the Counter-Reformation, Jolley demonstrates that the patriarchal portrayal of the Magdalene as a sexualised penitent and mournful witness to the resurrection is sustained by its mythic attachment to biblical text. Rather than adopting the same tropes uncritically, we are invited to look again at artworks and related texts in order to explore what happens when the influence of patriarchy is actively and intersectionally resisted. Ultimately, the Magdalene is transformed from a reductive and patriarchally mythologised figure to a multidimensional character, who is relatable and liberative as an exemplar.