bluuebunny/crossref_metadata_2025_split huggingface dataset:
Risk factors for adverse outcomes following surgical repair of esophageal atresia. A retrospective cohort study
Authors: Zouari Mohamed , Ameur Hana Ben , Krichen Emna , Saad Nesrine Ben , Dhaou Mahdi Ben , Mhiri Riadh 
Published: October 2022

SummaryEsophageal atresia (EA) is a life-threatening congenital malformation of the esophagus. Despite considerable recent advances in perinatal resuscitation and neonatal care, EA remains an important cause of mortality and morbidity, especially in low-income countries. The aim of this study was to assess risk factors for adverse outcomes following surgical repair of EA at a single center in Tunisia. We performed a retrospective analysis using medical records of neonates with surgical management of EA at our institution from 1 January 2007 to 31 December 2021. In total, 88 neonates were included with a mortality rate of 25%. There were 29 girls and 59 boys. The diagnosis of EA was suspected prenatally in 19 patients. The most common associated anomalies were congenital heart diseases. Prematurity, low birth weight, outborn birth, age at admission &gt;12 hours, congenital heart disease, postoperative sepsis, and anastomotic leak were risk factors for mortality following surgical repair of EA. Anastomotic tension was the only factor associated with short-term complications and the occurrence of short-term complications was predictive of mid-term complications. This study provides physicians and families with contemporary information regarding risk factors for adverse outcomes following surgical repair of EA. Thus, any effort to reduce these risk factors would be critical to improving patient outcomes and reducing cost. Future multi-institutional studies are needed to identify, investigate, and establish best practices and clinical care guidelines for neonates with EA.
Simulation of Forest Distribution in the Qilian Mountains of China with a Terrain-based Logistic Regression Model
Authors: Fang Shu , He Zhibin , Zhao Minmin 
Published: October 2022

Abstract
Predicting vegetation distribution strengthens ecosystem management, protection, and restoration in arid and degraded areas. However, data quality and incomplete data coverage limit prediction accuracy for Picea crassifolia Kom. (Qinghai spruce) forest in the Qilian Mountains of China. Here, we used a logistic regression model combined with high-resolution vegetation distribution data for different sampling scales and digital elevation models (DEMs) to determine the potential distribution of P. crassifolia forest in the Dayekou catchment in the Qilian Mountains. We found that the model with the best simulation accuracy was based on data with a DEM scale of 30 m and a sampling accuracy of 90 m (Nagelkerke’s R2 = 0.48 and total prediction accuracy = 83.89%). The main factors affecting the distribution of P. crassifolia forest were elevation and potential solar radiation. We conclude that it is feasible to calculate the distribution of arid mountain forests based on terrain and that terrain data at 30 m spatial resolution can fully support the simulation of P. crassifolia forest distribution.
Generation and characterization of conditional yeast mutants affecting each of the 2 essential functions of the scaffolding proteins Boi1/2 and Bem1
Authors: Sulpizio Abigail , Herpin Lancelot , Gingras Robert , Liu Wenyu , Bretscher Anthony 
Published: October 2022

AbstractBoi1 and Boi2 are closely related yeast scaffolding proteins, either of which can perform an essential function. Previous studies have suggested a role in cell polarity, interacting with lipids, components of the late secretory pathway, and actin nucleators. We report detailed studies of their localization, dynamics, and the generation and characterization of conditional mutants. Boi1/2 are present on the plasma membrane in dynamic patches, then at the bud neck during cytokinesis. These distributions are unaffected by perturbation of the actin cytoskeleton or the secretory pathway. We identify 2 critical aromatic residues, present in both Boi1 and Boi2, in the essential C-terminal Pleckstrin-Homology domain, that cause temperature-sensitive growth resulting in defects in polarized growth leading to cell lysis. The scaffolding protein, Bem1, colocalizes with Boi1 in patches at the growing bud, and at the bud neck, the latter requiring the N-terminal SH3 domain of Boi1p. Loss of function of Boi1-SH3 domain renders Bem1 essential, which can be fully replaced by a fusion of the SH3b and PB1 domains of Bem1. Thus, the 2 essential functions of the Boi1/2/Bem1 proteins can be satisfied by Bem1-SH3b-PB1 and Boi1-Pleckstrin-Homology. Generation and characterization of conditional mutations in the essential function of Bem1 reveal a slow onset of defects in polarized growth, which is difficult to define a specific initial defect. This study provides more details into the functions of Boi1/2 and their relationship with Bem1 and presents the generation of conditional mutants that will be useful for future genetic analysis.
Anomalies and transient variations of b-value in Italy during the major earthquake sequences: what truth is there to this?
Authors: Lombardi A M 
Published: October 2022

SUMMARY
The Gutenberg–Richter b-value is thought to be a proxy of stress conditions in the crust and therefore able to locate asperities as zones of stress concentration responsible for the nucleation of strong events. The scientific literature contains a broad range of case studies showing precursory drops of b, just before the occurrence of strong events, and subsequent rises, during the early part of aftershocks sequences. Translating these results into hazard assessment, the b-value has assumed the status of a candidate precursor to the occurrence of an imminent large event. This issue is analysed here for three major seismic sequences that occurred recently in Italy. In comparison to previous studies, this investigation indicates that the variability of b may not be a reliable indicator of stress or a significant precursor in these examples, and instead may be assigned to a combination of chance, inhomogeneities in the data and inefficiencies in estimation methodologies. Consequently, extreme caution is required when we interpret b-values both as a proxy of physical processes involved in a seismic sequence and as a precursor to the occurrence of imminent strong events.
Incorporating non-stationary spatial variability into dynamic species distribution models
Authors: Ward Eric J , Barnett Lewis A K , Anderson Sean C , Commander Christian J C , Essington Timothy E 
Published: October 2022

Abstract
Ecologists and fisheries scientists are faced with forecasting the ecological responses of non-stationary processes resulting from climate change and other drivers. While much is known about temporal change, and resulting responses vis-à-vis species distributional shifts, less is known about how spatial variability in population structure changes through time in response to temporal trends in drivers. A population experiencing decreasing spatial variability would be expected to be more evenly spatially distributed over time, and an increasing trend would correspond to greater extremes or patchiness. We implement a new approach for modelling this spatiotemporal variability in the R package sdmTMB. As a real-world application, we focus on a long-term groundfish monitoring dataset, from the west coast of the USA. Focusing on the 36 species with the highest population densities, we compare our model with dynamic spatiotemporal variance to a model with constant spatiotemporal variance. Of the 36 species examined, 13 had evidence to support increasing patchiness, including darkblotched rockfish, lingcod, and petrale sole. Species appearing to be more uniformly spatially distributed over time included: Dover sole, Pacific ocean perch, and Dungeness crab. Letting spatiotemporal variation change through time generally results in small differences in population trend estimates, but larger estimated differences in precision.
Lung transplantation in patients with a history of anatomical native lung resection
Authors: Iskender Ilker , Pecoraro Ylenia , Moreno Casado Paula , Kubisa Bartosz , Schiavon Marco , Faccioli Eleonora , Ehrsam Jonas , Damarco Francesco , Nosotti Mario , Inci Ilhan , Venuta Federico , Van Raemdonck Dirk , Ceulemans Laurens J 
Published: October 2022

Abstract

OBJECTIVES
History of anatomical lung resection complicates lung transplantation (LTx). Our aim was to identify indications, intraoperative approach and outcome in these challenging cases in a retrospective multicentre cohort analysis.

METHODS
Members of the ESTS Lung Transplantation Working Group were invited to submit data on patients undergoing LTx after a previous anatomical native lung resection between January 2005 and July 2020. The primary end point was overall survival (Kaplan–Meier estimation).

RESULTS
Out of 2690 patients at 7 European centres, 26 (1%) patients (14 males; median age 33 years) underwent LTx after a previous anatomical lung resection. The median time from previous lung resection to LTx was 12 years. The most common indications for lung resection were infections (n = 17), emphysema (n = 5), lung tumour (n = 2) and others (n = 2). Bronchiectasis (cystic fibrosis or non-cystic fibrosis related) was the main indication for LTx (n = 21), followed by COPD (n = 5). Two patients with a previous pneumonectomy underwent contralateral single LTx and 1 patient with a previous lobectomy had ipsilateral single LTx. The remaining 23 patients underwent bilateral LTx. Clamshell incision was performed in 12 (46%) patients. Moreover, LTx was possible without extracorporeal life support in 13 (50%) patients. 90-Day mortality was 8% (n = 2) and the median survival was 8.7 years.

CONCLUSIONS
The history of anatomical lung resection is rare in LTx candidates. The majority of patients are young and diagnosed with bronchiectasis. Although the numbers were limited, survival after LTx in patients with previous anatomical lung resection, including pneumonectomy, is comparable to reported conventional LTx for bronchiectasis.
Endoscopic mitral valve repair utilizing cavitron ultrasonic surgical aspirator for active endocarditis
Authors: Hosoba Soh , Ito Toshiaki , Kato Riku 
Published: October 2022

Abstract
Mitral valve repair for endocarditis in an acute setting is still challenging due to difficulties in debriding friable tissue and in leaving enough non-infected tissue for reconstruction. Endoscopic approaches for complex mitral valve procedures via a minimally invasive approach have been reported from high-volume programs. However, the role of endoscopic mitral valve surgery for acute infective endocarditis has not been clearly defined. We report our technique of endoscopic mitral valve repair using the cavitron ultrasonic surgical aspirator system for active endocarditis. The cavitron ultrasonic surgical aspirator with a low power setting provides enough debridement of the infective tissue and leaves healthy tissue adequate for repair under a totally endoscopic vision.
Why uterine transplantation requires us to rethink the role of the pre-conception welfare principle
Authors: O’Donovan Laura 
Published: October 2022

Abstract
Uterine transplantation (UTx) is a programme of treatment aimed at providing a unique solution to absolute uterine factor infertility, enabling patients to have children as a result of their own pregnancies. As a transplant procedure performed for fertility purposes it may be thought obvious that the welfare of any children created should be assessed prior to treatment provision. However, major concerns about the breadth and scope of such requirements, and the potential threat they pose to patients' reproductive autonomy, have been raised. In this paper, I analyse novel questions regarding the role of the pre-conception welfare principle in UTx. After outlining traditional critiques of the principle, I focus on the unique issues raised by its application in the two areas of medicine occupied by UTx. As a treatment for a particular form of infertility, I explore whether law and policy regulating traditional assisted reproductive technologies applies equally to the case of UTx, and whether a distinction (in welfare terms) does and should exist between fertility treatment involving gametes and embryos and gynaecological surgery for fertility purposes. As a quality-of-life-enhancing transplant, I consider and reject proposals in favour of using pre-conception welfare considerations to inform patient listing and the allocation of deceased donor uteri on the grounds that such assessments may both compromise patient autonomy and lead to unjust discrimination against particular patients or groups of patients.
Diagnosis and management of breast implant capsule recurrence following mastectomy and subpectoral implant – innovative use of ADM for reconstruction
Authors: Soh Chien Lin , Asher Christian M , Forouhi Parto , Moyle Penelope , Healy Nuala Ann , Malata Charles M 
Published: October 2022

Abstract
It is well reported that patients who have undergone breast augmentation and subsequently develop breast cancer can successfully undergo breast-conserving therapy with preservation of their implants. However, there is a paucity of literature on the radiological investigations and surgical techniques in postmastectomy implant-reconstructed patients who develop recurrences to enable preservation of their implant-based reconstruction whilst effectively treating the local recurrence. The wide adoption of acellular dermal matrix use in prosthetic breast reconstruction in recent years has made radiological evaluation of such patients challenging. Herein presented is a case of a 37-year-old woman where wide local excision of a local recurrence abutting a peri-implant capsule following previous mastectomy and implant-acellular dermal matrix (ADM) reconstruction was performed with successful preservation of reconstruction volume (and shape) using an ADM patch to repair the capsular defect whilst retaining the implant in situ. Radiological investigation facilitated and guided the surgical planning and oncological clearance.
Galaxy Zoo: Clump Scout – Design and first application of a two-dimensional aggregation tool for citizen science
Authors: Dickinson Hugh , Adams Dominic , Mehta Vihang , Scarlata Claudia , Fortson Lucy , Serjeant Stephen , Krawczyk Coleman , Kruk Sandor , Lintott Chris , Mantha Kameswara Bharadwaj , Simmons Brooke D , Walmsley Mike 
Published: October 2022

ABSTRACT
Galaxy Zoo: Clump Scout  is a web-based citizen science project designed to identify and spatially locate giant star forming clumps in galaxies that were imaged by the Sloan Digital Sky Survey Legacy Survey. We present a statistically driven software framework that is designed to aggregate two-dimensional annotations of clump locations provided by multiple independent Galaxy Zoo: Clump Scout volunteers and generate a consensus label that identifies the locations of probable clumps within each galaxy. The statistical model our framework is based on allows us to assign false-positive probabilities to each of the clumps we identify, to estimate the skill levels of each of the volunteers who contribute to Galaxy Zoo: Clump Scout and also to quantitatively assess the reliability of the consensus labels that are derived for each subject. We apply our framework to a data set containing 3561 454 two-dimensional points, which constitute 1739 259 annotations of 85 286 distinct subjects provided by 20 999 volunteers. Using this data set, we identify 128 100 potential clumps distributed among 44 126 galaxies. This data set can be used to study the prevalence and demographics of giant star forming clumps in low-redshift galaxies. The code for our aggregation software framework is publicly available at: https://github.com/ou-astrophysics/BoxAggregator
Homeobox A3 and KDM6A cooperate in transcriptional control of aerobic glycolysis and glioblastoma progression
Authors: Yang Rui , Zhang Guanghui , Dong Zhen , Wang Shanshan , Li Yanping , Lian Fuming , Liu Xiaoran , Li Haibin , Wei Xiaonan , Cui Hongjuan 
Published: October 2022

AbstractBackgroundAlterations in transcriptional regulators of glycolytic metabolism have been implicated in brain tumor growth, but the underlying molecular mechanisms remain poorly understood.MethodsKnockdown and overexpression cells were used to explore the functional roles of HOXA3 in cell proliferation, tumor formation, and aerobic glycolysis. Chromatin immunoprecipitation, luciferase assays, and western blotting were performed to verify the regulation of HK2 and PKM2 by HOXA3. PLA, Immunoprecipitation, and GST-pull-down assays were used to examine the interaction of HOXA3 and KDM6A.ResultsWe report that transcription factor homeobox A3 (HOXA3), which is aberrantly highly expressed in glioblastoma (GBM) patients and predicts poor prognosis, transcriptionally activates aerobic glycolysis, leading to a significant acceleration in cell proliferation and tumor growth. Mechanically, we identified KDM6A, a lysine-specific demethylase, as an important cooperator of HOXA3 in regulating aerobic glycolysis. HOXA3 activates KDM6A transcription and recruits KDM6A to genomic binding sites of glycolytic genes, targeting glycolytic genes for transcriptional activation by removing the suppressive histone modification H3K27 trimethylation. Further evidence demonstrates that HOXA3 requires KDM6A for transcriptional activation of aerobic glycolysis and brain tumor growth.ConclusionsOur findings provide a novel molecular mechanism linking HOXA3-mediated transactivation and KDM6A-coupled H3K27 demethylation in regulating glucose metabolism and GBM progression.
Neurological applications of belzutifan in von Hippel-Lindau disease
Authors: Zhang Yue , Nguyen Catherine C , Zhang Nigel T , Fink Nicolas S , John Jordan D , Venkatesh Omkar G , Roe Jonathan D , Hoffman Steven C , Lesniak Maciej S , Wolinsky Jean-Paul , Horbinski Craig , Szymaniak Brittany M , Buerki Robin A , Sosman Jeffrey A , Shenoy Niraj K , Lukas Rimas V 
Published: October 2022

Abstract
Von Hippel-Lindau (VHL) disease is a tumor predisposition syndrome caused by mutations in the VHL gene that presents with visceral neoplasms and growths, including clear cell renal cell carcinoma, and central nervous system manifestations, such as hemangioblastomas of the brain and spine. The pathophysiology involves dysregulation of oxygen sensing caused by the inability to degrade HIFα, leading to the overactivation of hypoxic pathways. Hemangioblastomas are the most common tumors in patients with VHL and cause significant morbidity. Until recently, there were no systemic therapies available for patients that could effectively reduce the size of these lesions. Belzutifan, the first approved HIF-2α inhibitor, has demonstrated benefit in VHL-associated tumors, with a 30% response rate in hemangioblastomas and ~30%–50% reduction in their sizes over the course of treatment. Anemia is the most prominent adverse effect, affecting 76%–90% of participants and sometimes requiring dose reduction or transfusion. Other significant adverse events include hypoxia and fatigue. Overall, belzutifan is well tolerated; however, long-term data on dosing regimens, safety, and fertility are not yet available. Belzutifan holds promise for the treatment of neurological manifestations of VHL and its utility may influence the clinical management paradigms for this patient population.
Association of hyperglycemia and molecular subclass on survival in IDH-wildtype glioblastoma
Authors: Liu Elisa K , Vasudevaraja Varshini , Sviderskiy Vladislav O , Feng Yang , Tran Ivy , Serrano Jonathan , Cordova Christine , Kurz Sylvia C , Golfinos John G , Sulman Erik P , Orringer Daniel A , Placantonakis Dimitris , Possemato Richard , Snuderl Matija 
Published: October 2022

Abstract

Background
Hyperglycemia has been associated with worse survival in glioblastoma. Attempts to lower glucose yielded mixed responses which could be due to molecularly distinct GBM subclasses.

Methods
Clinical, laboratory, and molecular data on 89 IDH-wt GBMs profiled by clinical next-generation sequencing and treated with Stupp protocol were reviewed. IDH-wt GBMs were sub-classified into RTK I (Proneural), RTK II (Classical) and Mesenchymal subtypes using whole-genome DNA methylation. Average glucose was calculated by time-weighting glucose measurements between diagnosis and last follow-up.

Results
Patients were stratified into three groups using average glucose: tertile one (&lt;100 mg/dL), tertile two (100–115 mg/dL), and tertile three (&gt;115 mg/dL). Comparison across glucose tertiles revealed no differences in performance status (KPS), dexamethasone dose, MGMT methylation, or methylation subclass. Overall survival (OS) was not affected by methylation subclass (P = .9) but decreased with higher glucose (P = .015). Higher glucose tertiles were associated with poorer OS among RTK I (P = .08) and mesenchymal tumors (P = .05), but not RTK II (P = .99). After controlling for age, KPS, dexamethasone, and MGMT status, glucose remained significantly associated with OS (aHR = 5.2, P = .02). Methylation clustering did not identify unique signatures associated with high or low glucose levels. Metabolomic analysis of 23 tumors showed minimal variation across metabolites without differences between molecular subclasses.

Conclusion
Higher average glucose values were associated with poorer OS in RTKI and Mesenchymal IDH-wt GBM, but not RTKII. There were no discernible epigenetic or metabolomic differences between tumors in different glucose environments, suggesting a potential survival benefit to lowering systemic glucose in selected molecular subtypes.
Nutritional and health-promoting attributes of millet: current and future perspectives
Authors: Samtiya Mrinal , Aluko Rotimi E , Dhaka Namrata , Dhewa Tejpal , Puniya Anil Kumar 
Published: October 2022

Abstract
Millet is consumed as a staple food, particularly in developing countries, is part of the traditional diet in a number of relatively affluent countries, and is gaining popularity throughout the world. It is a valuable dietary energy source. In addition to high caloric value, several health-promoting attributes have been reported for millet seeds. This review describes many nutritional characteristics of millet seeds and their derivatives that are important to human health: antioxidant, antihypertensive, immunomodulatory or anti-inflammatory, antibacterial or antimicrobial, hypocholesterolemic, hypoglycemic, and anti-carcinogenic potential, and their role as modulators of gut health. There are several varieties, but the main focus of this review is on pearl millet (Cenchrus americanus [synonym Pennisetum glaucum]), one of the most widely eaten millet crops grown in India, though other millet types are also covered. In this article, the health-promoting properties of the natural components (ie, proteins, peptides, polyphenols, polysaccharides, oil, isoflavones, etc.) present in millet seeds are discussed. Although many of these health benefits have been demonstrated using animal models in vitro studies, human intervention-feeding trials are required to confirm several of the potential health benefits of millet seeds. Based on the nutritional and health-promoting attributes known for pearl millet (discussed in this review), finger millet and foxtail millet are suggested as good candidates for use in future nutritional interventions for improved human health.
Multiple Lytic Bone Lesions Mimicking Langerhans Cell Histiocytosis: A Case of Infantile Mendelian Susceptibility to Mycobacterial Disease due to STAT1 Deficiency
Authors: He Yingyi , Zhang Hui , Li Chunjie , Su Xiaoling , Gan Wenting , Wang Pengfei , Xiao Weiqiang 
Published: October 2022

Abstract
We present the first infantile disseminated Bacillus Calmette-Guérin (BCG) disease case with STAT1 deficiency, which is manifested by multiple Langerhans cell histiocytosis–like osteolytic lesions. The diagnosis of BCG-induced osteomyelitis was not initially considered until the additional biopsy revealing granulomatous inflammation, a key pathological diagnostic component for mycobacterial infection.