bluuebunny/crossref_metadata_2025_split huggingface dataset:
Treosulfan compared with reduced‐intensity busulfan improves allogeneic hematopoietic cell transplantation outcomes of older acute myeloid leukemia and myelodysplastic syndrome patients: Final analysis of a prospective randomized trial
Authors: Beelen Dietrich W. , Stelljes Matthias , Reményi Péter , Wagner‐Drouet Eva‐Maria , Dreger Peter , Bethge Wolfgang , Ciceri Fabio , Stölzel Friedrich , Junghanß Christian , Labussiere‐Wallet Hélène , Schaefer‐Eckart Kerstin , Grigoleit Goetz U. , Scheid Christof , Patriarca Francesca , Rambaldi Alessandro , Niederwieser Dietger , Hilgendorf Inken , Russo Domenico , Socié Gérard , Holler Ernst , Glass Bertram , Casper Jochen , Wulf Gerald , Basara Nadezda , Bieniaszewska Maria , Stuhler Gernot , Verbeek Mareike , La Rocca Ursula , Finke Jürgen , Benedetti Fabio , Pichlmeier Uwe , Klein Anja , Baumgart Joachim , Markiewicz Miroslaw 
Published: May 2022

AbstractThe phase III study was designed to compare event‐free survival (EFS) after treosulfan‐based conditioning with a widely applied reduced‐intensity conditioning (RIC) busulfan regimen in older or comorbid patients with acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS) undergoing allogeneic hematopoietic cell transplantation (HCT). A previously reported confirmatory interim analysis of the randomized clinical study including 476 patients demonstrated statistically significant noninferiority for treosulfan with clinically meaningful improvement in EFS. Here, the final study results and pre‐specified subgroup analyses of all 570 randomized patients with completed longer‐term follow‐up are presented. Patients presenting HCT‐specific comorbidity index >2 or aged ≥50 years were randomly assigned (1:1) to intravenous (IV) fludarabine with either treosulfan (30 g/m2 IV) or busulfan (6.4 mg/kg IV) after stratification by disease risk group, donor type, and participating institution. The primary endpoint was EFS with disease recurrence, graft failure, or death from any cause as events. EFS of patients (median age 60 years) was superior after treosulfan compared to RIC busulfan: 36‐months‐EFS rate 59.5% (95% CI, 52.2–66.1) vs. 49.7% (95% CI, 43.3–55.7) with a hazard ratio (HR) of 0.64 (95% CI, 0.49–0.84), p = 0.0006. Likewise, overall survival (OS) with treosulfan was superior compared to busulfan: 36‐month‐OS rate 66.8% vs. 56.3%; HR 0.64 (95% CI, 0.48–0.87), p = 0.0037. Post hoc analyses revealed that these differences were consistent with the confirmatory interim analysis, and thereby the treosulfan regimen appears particularly suitable for older AML and MDS patients.
Photo‐Driven Radical Addition/Cyclization of Biaryl Vinyl Ketones with CF3SO2Na and ArCF2CO2K without an External Photocatalyst
Authors: Yang Xingyu , Liu Jie , Gao Yanhui , Wang Lei , Zhang Yicheng , Li Pinhua 
Published: May 2022

AbstractA new strategy for the preparation of 10,10‐disubsituedphenanthren‐9(10H)‐ones via a photo‐driven radical addition/cyclization of biaryl vinyl ketones with CF3SO2Na and ArCF2CO2K has been developed. The reactions can proceed smoothly in air at room temperature under 380–385 nm LED irradiation without any external photocatalyst, and the corresponding products were obtained in 55–89% yields.
Gast‐modulierte Zirkular Polarisierte Lumineszenz via Ligand‐zu‐Ligand Chiralitätstransfer in Heteroleptischen PdII Käfigen
Authors: Wu Kai , Tessarolo Jacopo , Baksi Ananya , Clever Guido H. 
Published: May 2022

AbstractDie Mehrkomponenten‐Assemblierung metallo‐supramolekularer Komplexe erlaubt die gezielte Kombination verschiedener Bausteine. Definierte multifunktionale Wirte mit einer zugänglichen Kavität können so auf nicht‐statistische Weise dargestellt werden. Wir nutzen unsere Methode der formkomplementären Assemblierung (shape complementary assembly, SCA), um erstmalig die integrative Selbstsortierung heteroleptischer PdII‐Käfige zu erzielen, welche eine durch den Gast modulierte zirkular polarisierte Lumineszenz (circularly polarized luminescence, CPL) zeigen. Ein enantiomerenreiner Ligand auf Basis von Helicen (M‐ oder P‐Konfiguration) wird dabei mit einem nicht‐chiralen, emittierenden Liganden auf Basis von Fluorenon (A oder B) kombiniert, um eine Reihe von Pd2L2L′2 Käfigen zu bilden. Die modulare Strategie ermöglicht es, die chirale Information des Helicens auf das gesamte supramolekulare System zu übertragen, was zu CPL‐Emission aus der nicht‐chiralen Komponente führt. Die Bindung eines Gastes führt zu einer 4‐fachen Erhöhung der CPL‐Intensität. Das hier vorgestellte System bietet das Potential, Bibliotheken multifunktionaler Materialien herzustellen, welche in der molekularen Erkennung, der enantioselektiven Photo‐Redox‐Katalyse und der Informationsverarbeitung eingesetzt werden können.
Green‐Light‐Driven Reductive Elimination of Chlorine from a Carbene‐Xanthylium Gold(III) Complex
Authors: Park Gyeongjin , Karimi Mohammadjavad , Liu Wei‐Chun , Gabbaï François P. 
Published: May 2022

AbstractWith the discovery of late transition metal platforms that support clean photoreductive halogen eliminations, we now describe an indazol‐3‐ylidene gold trichloride complex ([7]+) decorated at the 4‐position by a xanthylium unit. This orange complex features a low energy band in the visible part of the spectrum, assigned to the charge transfer excitation of the indazol‐3‐ylidene/xanthylium donor/acceptor dyad. Green‐light irradiation of this complex in the presence of a chlorine trap elicits the clean photoelimination of chlorine radicals, producing the corresponding gold(I) complex. This visible‐light‐induced photoreduction is very efficient, reaching quantum yields close to 10 %. A neutral analog of [7]+ featuring an anthryl group rather than a xanthylium unit proved to be perfectly photostable, supporting the importance of the xanthylium‐based photoredox unit present in [7]+.
Magnetic properties of the mononuclear iron (III) complexes with biphenyl‐disubstituted Schiff base ligand: EPR and SQUID study
Authors: Vorobeva Valerya , Starichenko Denis , Gruzdev Matvey , Chervonova Ulyana , Zaripov Ruslan , Korolev Aleksander 
Published: May 2022

The magnetic features of the mononuclear iron (III) complexes [Fe(L)2]+X−with tridentate Schiff base ligands [where L is 4‐(4‐diphenylcarboxy)‐2′‐oxysalicylidene‐N′‐ethylene‐N‐ethylene‐2′‐amine‐(carboxy‐4‐diphenyl) and X− = Cl−(1), PF6−(2) and NO3−(3) counter‐ions] have been studied by electron paramagnetic resonance (EPR) spectroscopy, SQUID (superconducting quantum interference device) magnetometry (solid), and Evans1H nuclear magnetic resonance method (solution). EPR established that compounds (1) and (2) consist of two types high‐spin (HS, S = 5/2) centers with weak distorted and strong low‐symmetry octahedral crystal fields. The signals from low‐spin centers (LS, S = 1/2) of Fe (III) are observed in the spectra of compounds2and3. SQUID revealed permanent HS behavior in (1) and mixed LS + HS in (2), (3) in wide temperature range, while solution method—only HS. Magnetic measurements allowed to estimate part of HS and LS fractions and detected antiferromagnetic exchange interactions between the neighboring Fe (III) ions in complexes.“
Active Shooter Preparedness: Is Your OR Ready?
Authors: Scott‐Herring Mary 
Published: May 2022

ABSTRACTActive shooter events, including those in health care facilities, are expected to increase in incidence. Perioperative personnel may be underprepared for such an event. Understanding how to make the best decision regarding whether to escape, hide, or fight, and being aware of the communication channels during these types of events are crucial to adequate preparation. Health care facilities and critical areas such as the OR should be prepared for an active shooter event. This article briefly describes a firsthand shooting event experience at Johns Hopkins Hospital and includes a review of the literature on active shooter events in health care settings to determine the most practical application of event preparedness for staff members working in the OR. It also discusses the highly relevant concept of patient abandonment.
Poly(3,4‐ethylenedioxythiophene):Poly(styrene sulfonate) in antibacterial, tissue engineering and biosensors applications: Progress, challenges and perspectives
Authors: Gupta Sonal , Datt Ram , Mishra Anamika , Tsoi Wing Chung , Patra Asit , Bober Patrycja 
Published: May 2022

AbstractWith the advancement of applications in biomedicines and bioelectronics, conducting polymers have attained huge significant attention. For such applications, poly(3,4‐ethylenedioxythiophene):poly(styrene sulfonate) (PEDOT:PSS) is considered a potential conducting polymer because of its low cost, considerable stability, high conductivity and mechanical strength. Most importantly, its easy aqueous solution processability makes it more attractive. Over the last few years, PEDOT:PSS has been predominantly explored and investigated for different optoelectronic flexible devices, and recently it has been studied for biomedical applications. PEDOT:PSS based materials have made progress in biomedicines due to their properties such as biocompatibility, cell proliferation, antibacterial, nontoxicity and so forth. To adjust the desirable properties, special attention is required for altering the structure of PEDOT:PSS material. PEDOT:PSS offers excellent antibacterial properties against both gram‐positive and gram‐negative bacteria. Moreover, PEDOT:PSS demonstrates an important role in sensing human body humidity, pressure control, glucose detection, as well as employed in human sweat sensors. Besides these, PEDOT:PSS has been studied as a scaffold for endothelial cell preservation. There are several issues which need to be resolved in the future, such as improved biocompatibility and stability to explore the PEDOT:PSS based composite materials in biomedical applications. However, a related review article is lacking, directed on the PEDOT:PSS biomedical applications, namely, antibacterial, tissue engineering, and biosensing. Therefore, the current article summarizes importance of PEDOT:PSS for biomedical applications, and main emphasis is given to its recent advances, challenges and perspectives.
TMEDA‐Catalyzed Regioselective Decarboalkoxy C−N Bond Formation: A Unified Direct Access to Indolo[2,1‐a]isoquinoline and Dibenzopyrrocoline Alkaloids
Authors: Yadav Lalit , Kumar Shyamlal Bharti Rajesh , Tiwari Mohit K. , Rahaman T. A Abdul , Sen Janmejaya , Chaudhary Sandeep 
Published: May 2022

AbstractAn unprecedented TMEDA‐catalyzed, regioselective, decarboethoxy direct C−N coupling protocol towards the synthesis of dibenzopyrrocolines 17 a–i and 5,6‐dihydroindolo[2,1‐a]isoquinoline 15 a–f/18 a–c alkaloids via the identification of N,N,N′,N′‐tetramethylethylenediamine (TMEDA) as a homogeneous catalyst is reported. The transition‐metal‐free, TMEDA‐catalytic novel protocol is operationally simple and showed a wide range of functional group tolerance and substrate compatibility. The gram‐scale application and synthesis of naturally occurring Cryptaustoline (dibenzopyrrocoline) alkaloid, further highlights the importance and versatile nature of the developed protocol. This finding also offers a TMEDA‐catalyzed direct synthesis of dibenzopyrrocolines and substituted 5,6‐dihydroindolo[2,1‐a]isoquinoline compounds in a one‐pot. The probable reaction pathway involves the free‐radical sequential approach via a single electron transfer (SET) mechanism.
Chemoenzymatic Synthesis of Globo‐series Glycosphingolipids and Evaluation of Their Immunosuppressive Activities
Authors: Chiang Pei‐Yun , Adak Avijit K. , Liang Wei‐Lun , Tsai Chen‐Yen , Tseng Hsin‐Kai , Cheng Jing‐Yan , Hwu Jih Ru , Yu Alice L. , Hung Jung‐Tung , Lin Chun‐Cheng 
Published: May 2022

AbstractGlycosphingolipids (GSLs) play essential roles in many important biological processes, making them attractive synthetic targets. In this paper, a viable chemoenzymatic method is described for the synthesis of globo‐series GSLs, namely, Gb4, Gb5, SSEA‐4, and Globo H. The strategy uses a chemically synthesized lactoside acceptor equipped with a partial ceramide structure that is uniquely extended by glycosyltransferases in a highly efficient one‐pot multiple enzyme (OPME) procedure. A direct and quantitative conversion of Gb4 sphingosine to Globo H sphingosine is achieved by performing two‐sequential OPME glycosylations. A reduction andN‐acylation protocol allows facile incorporation of various fatty acids into the lipid portions of the GSLs. The chemically well‐defined lipid‐modified Globo H‐GSLs displayed some differences in their immunosuppressive activities, which may benefit the structural modifications of Globo H ceramides in finding new types of immunosuppressive agents. The strategy outlined in this work should be applicable to the rapid access to other complex GSLs.
Bausteine zu einer Oral History der Wissenschaftsgeschichte Wissenschaft als Arbeitsprozess. Interview mit Wolfgang Lefèvre
Authors: Grote Mathias , te Heesen Anke , Lefèvre Wolfgang 
Published: May 2022

AbstractWie kann man einen historischen Blick auf das eigene Fach werfen? Diese Frage ist nicht einfach zu beantworten – will man einerseits nicht in einer Nabelschau und Hagiographie enden, andererseits aber auch keinen umfassenden Entwurf einer zukünftigen Historiographie vorlegen. Die hier als Bausteine zu einer Oral History der Wissenschaftsgeschichte in loser Folge publizierten Interviews mit bekannten Protagonisten der Berliner Wissenschaftsgeschichte von ca. 1970–1990 in West und Ost rücken die Geschichte des Faches deshalb in einem bestimmten Milieu in den Fokus und versuchen, die Historiographie jenseits einer Institutionen‐ oder Theoriegeschichte voranzutreiben. Welche Motivationen oder Probleme bewegten einzelne Wissenschaftler:innen, sich der Geschichte ihres Faches zu widmen oder sich etwa aus der Soziologie oder Philosophie in die Wissenschaftsgeschichte zu bewegen? Welche Ausbildungspraxen existierten in diesem heterogenen, zwischen den Disziplinen angesiedelten Feld, welche Anregungen bezog man aus welchen Kontexten? Wie war Lehre strukturiert und welche Netzwerke bildeten sich mit der Zeit? Kurz: Mit welchem Interesse kam man zur Wissenschaftsgeschichte und was wurde daraus? Die Auswahl der Interviewees erfolgt ohne Anspruch auf Vollständigkeit oder Proporz; der Fragenkatalog der Interviews richtet sich individuell nach den Biographien und dem Werk und entfaltet sich oft spontan im Gespräch. Die Interviews wurden digital aufgezeichnet, transkribiert, der Schriftsprache angepasst, gegebenenfalls gekürzt, annotiert und von den Interviewees authentifiziert. Wir beabsichtigen mit dieser Serie von Interviews zunächst die Dokumentation rezenter Geschichte durch eine Oral History, die subjektive Wahrnehmungen und persönliche Erlebnisse einschließt. Auf diese Weise werden Segmente einer größtenteils ungeschriebenen Geschichte anhand von Biographien erfahrbar und damit auch einer weiteren kritischen Bearbeitung und Integration in ein Gesamtbild zugänglich. Da uns im Zuge der jeweiligen Vorbereitung und Durchführung, Transkription und Abstimmung der Interviews daran gelegen war, aus Sicht der Akteure wichtige Sammelbände und Aufsätze, Graue Literatur oder Monographien zu erfassen, wird nebenbei eine kommentierte Bibliographie zur Geschichte der Wissenschaftsgeschichte entstehen. Unsere Hoffnung besteht darin, mittels dieser Sammlung mit Berlin einen fruchtbaren Raum und mit den 1970er und 1980er Jahren eine produktive Zeit des Faches jenseits von Reminiszenz oder Nostalgie zu erkunden nicht zuletzt auch, um den Blick für gegenwärtige Herausforderungen des Faches zu schärfen.Mathias Grote, Anke te Heesen
LncRNA MALAT1 promotes decidualization of endometrial stromal cells via sponging miR‐498‐3p and targeting histone deacetylase 4
Authors: Shi Lijuan , Zhu Lihua , Gu Qiao , Kong Chengcai , Liu Xinmei , Zhu Zonghao 
Published: May 2022

AbstractDecidualization of human endometrial stromal cells (hESCs) is important for the maintenance of a successful pregnancy. Histone deacetylase 4 (HDAC4) was reported to be involved in the dysfunction of decidua‐derived mesenchymal stem cells. However, the role of HDAC4 underlying decidualization of hESCs remains unclear. We intended to explore the function and molecular mechanism of HDAC4 in hESCs. In vitro expansion of hESCs using a serum‐free medium was used to confirm the characteristics of hESCs. Gene expression in hESCs was evaluated by reverse transcription‐quantitative polymerase chain reaction. CCK‐8 assay, TUNEL staining, flow cytometry analysis, and Western blot analysis were performed to test the effects of HDAC4 and metastasis‐associated lung adenocarcinoma transcript 1 (MALAT1) on hESCs. RNA pull‐down and luciferase reporter assays were performed to validate the relationship between genes. In this study, the characteristics of hESCs were sustained in serum‐free medium during a process of propagation. HDAC4 knockdown suppressed hESCs viability and promoted hESCs apoptosis. HDAC4 was targeted by miR‐498‐3p in hESCs. MALAT1 bound with miR‐498‐3p in hESCs. HDAC4 expression was positively regulated by MALAT1 and negatively regulated by miR‐498‐3p in hESCs. HDAC4 upregulation countervailed the effects of MALAT1 silencing on hESCs proliferation, apoptosis, and decidualization of hESCs. Overall, MALAT1 facilitated the decidualization of hESCs via binding with miR‐498‐3p and upregulating HDAC4, which might provide a new direction for the maintenance of a successful pregnancy.
Luminescent Pyrrole‐Based Phosphaphenalene Gold Complexes: Versatile Anticancer Tools with Wide Applicability
Authors: Fermi Valentina , Regulska Elzbieta , Wolfram Anna , Wessling Patrick , Rominger Frank , Herold‐Mende Christel , Romero‐Nieto Carlos 
Published: May 2022

AbstractInvited for the cover of this issue are the groups of Christel Herold‐Mende and Carlos Romero‐Nieto at the Universities of Heidelberg and Castilla–La Mancha. The image depicts the use of phosphaphenalene gold(I) complexes for the treatment of brain cancer. Read the full text of the article at 10.1002/chem.202104535.
Controllable Zeolite AST Crystallization: Between Classical and Reversed Crystal Growth
Authors: Yue Qiudi , Kutukova Kristina , Li Ang , Čejka Jiří , Zschech Ehrenfried , Opanasenko Maksym 
Published: May 2022

AbstractInvited for the cover of this issue are Maksym Opanasenko and co‐workers at Charles University in Prague, IKTS and deepXscan GmbH in Dresden. The image depicts a controllable crystallization mechanism that can be switched from classical to reversed crystal growth by manipulating the interplay between silica particles and the structure‐directing agent. Read the full text of the article at 10.1002/chem.202200590.
Further refining 2020ESGO/ESTRO/ESPmolecular risk classes in patients with early‐stage endometrial cancer: A propensity score–matched analysis
Authors: Nero Camilla , Pasciuto Tina , Cappuccio Serena , Corrado Giacomo , Pelligra Silvia , Zannoni Gian Franco , Santoro Angela , Piermattei Alessia , Minucci Angelo , Lorusso Domenica , Fanfani Francesco , Scambia Giovanni 
Published: May 2022

BackgroundThe integration of molecular features with clinicopathological findings in endometrial cancer classification seems to be able to significantly refine risk assessment. Nevertheless, clinical management remains challenging, and different therapeutic options are available for each class. Further prognostic characterization of the subgroups within each risk class could be helpful in the decision‐making process.MethodsThis study evaluated the role of the 2020 European Society of Gynaecological Oncology (ESGO)/European Society for Radiotherapy and Oncology (ESTRO)/European Society of Pathology (ESP) risk assessment system and the three prognostic profiles adopted in the PORTEC‐4a trial in predicting disease‐free and overall survival in a retrospective study cohort of patients with early‐stage endometrial cancer. Patients were selected according to a 1:2 propensity score matching analysis. Moreover, the sequencing of 29 genes was undertaken for tumor samples.ResultsThe study included 137 patients. No differences in disease‐free or overall survival at 5 years were observed among the 2020 ESGO/ESTRO/ESP risk classes without molecular features (p = .766 andp = .176, respectively). Once molecular features were integrated, the probability of overall survival was significantly different (p = .011). When the three prognostic profiles were applied, the probability of recurrence had apvalue of .097, and significant differences were observed in overall survival (p = .004). Among patients experiencing recurrence, 17.6% showed mutations inBRCA1/2, RAD50, BRIP1, andXRCC2, whereas 22.5% had PD‐L1–positive expression and anMUTYHmutation.ConclusionsFurther stratification within each risk class according to the most relevant prognostic features could better define the prognosis of patients with early‐stage endometrial cancer. Nearly half of the patients who experienced recurrence showed a targetable molecular alteration for which dedicated trials should be encouraged.
Effects of post‐flowering heat stress on chlorophyll content and yield components of a spring wheat diversity panel
Authors: Fu Jianming , Krishna Jagadish S. V. , Bowden Robert L. 
Published: May 2022

AbstractHigh temperature has been a major limiting factor for wheat (Triticum aestivum L.) productivity and will become a significant driver of yield loss as global warming progresses. Many wheat‐growing regions worldwide experience terminal heat stress during the grain‐filling period, resulting in grain yield reduction. A sustainable solution to mitigate heat stress‐induced damage is to develop heat‐tolerant cultivars. To achieve this, identifying tolerant lines is essential to incorporate heat stress resilience into commercial varieties. Our working hypothesis was that retaining chlorophyll content during post‐flowering heat stress will reduce yield losses. In this study, we evaluated the terminal heat stress tolerance of 254 diverse spring wheat lines from North American and Australian wheat‐breeding programs in two independent experiments. The plants were grown in individual pots under controlled environments. Significant genetic variation was observed for the ability to retain post‐stress chlorophyll content and yield components. Grain yield per plant and individual grain weight were significantly correlated with chlorophyll content under heat stress. The reduction in grain yield per plant was contributed more by the reduction of the individual grain weight than by the grain number under heat stress. A highly tolerant line, cultivar Otis, retained 79.2% chlorophyll content relative to control, and also recorded 55% greater chlorophyll content than the average of all 254 lines, at the end of 16 d of severe heat stress treatment. Mapping populations are being developed using Otis, with an aim to identify the genetic basis of chlorophyll retention under terminal heat stress. Resilient wheat lines identified with high grain weight under stress will serve as useful resources for abiotic stress breeding programs.