bluuebunny/crossref_metadata_2025_split huggingface dataset:
Relationship of sortilin and proprotein convertase subtilisin/kexin type 9 in blood serum with the severity of carotid and coronary atherosclerosis in hypertensive patients
Authors: Vukolova Yu. Yu. , Gubareva I. V. 
Published: June 2022

Sortilin is an important molecular protein involved in lipid metabolism, atherosclerosis, and aortic valve calcification. Sortilin presumably regulates the PCSK9 signaling pathways.Aim. To study correlations of sortilin and PCSK9 with atherosclerosis development in hypertensive patients.Material and methods. The study included 161 patients aged 30 to 65 years. We performed collection of complaints and anamnesis, physical examination, blood biochemical test with the determination of total cholesterol, low-density lipoprotein cholesterol, triglycerides, blood glucose, serum creatinine with estimation of glomerular filtration rate. Serum PCSK9, sortilin and interleukins 8, 10 were determined by enzyme-linked immunosorbent assay. The following investigations were also performed: electrocardiography, echocardiography, extracranial artery ultrasound, coronary angiography.Results. Sortilin levels (b=2,37; odds ratio (OR), 10,74; 95% CI, 1,05-109,47, p=0,045), IL-8 (b=-2,42; OR, 9,74; 95% CI, 0,01-0,81, p=0,032), age (b=0,21; OR, 1,24; 95% CI, 1,12-1,37, p<0,001) were identified as independent predictors of coronary atherosclerosis with a sensitivity of 87% and a specificity of 70%. PCSK9 (b=0,005; OR, 1,00; 95% CI, 1,00-1,01, p=0,038) and IL-8 (b= -0,33; OR, 0,72; 95% CI, 0,55-0,94, p=0,014) were identified as independent predictors of carotid atherosclerosis with a sensitivity of 75% and a specificity of 71%.Conclusion. In addition to non-invasive imaging, the determination of atherosclerosis biomarkers can make a significant contribution to the diagnosis and prediction of carotid and coronary atherosclerosis progression. It is noteworthy that not only PCSK9, but also sortilin can be a potential therapeutic target. Further large-scale studies are needed.
Treatment of iron deficiency in patients after acute decompensation: a new target in the treatment of heart failure
Authors: Zhirov I. V. , Safronova N. V. , Tereshchenko S. N. 
Published: June 2022

Iron deficiency (ID) is one of the most common comorbidities in patients with heart failure (HF). ID is a strong independent predictor of outcomes in HF patients. ID reduces quality of life, exercise tolerance, and survival in patients with HF, regardless of anemia status. The latest 2021 guidelines recommend initiating ID treatment at a ferritin <100 µg/L, or 100 to 299 µg/L, when transferrin saturation is less than 20%. The FAIR-HF and CONFIRM-HF studies have shown improvements in symptoms, quality of life, and functional status in patients with stable HF and ID after intravenous administration of ferric carboxymaltose (FCM). Moreover, the results of these studies showed a reduced risk of hospitalization for HF, which was later confirmed in a subsequent meta-analysis. Finally, the AFFIRM-AHF study, which evaluated the effect of FCM administration on outcomes in patients hospitalized for acute HF/acute decompensated HF, found a significant reduction in HF-related readmissions among patients treated with FCM.
Rationale and design of the open-label, prospective, randomized study of the efficacy of intravenous versus oral iron deficiency therapy in improving left ventricular systolic function in patients with myocardial infarction (OPERA-MI)
Authors: Khastieva D R , Malkova M I , Zakirova E B , Zakirova I I , Valeeva I H , Khasanov N R 
Published: June 2022

Aim. Iron has a protective effect on cardiomyocytes during hypoxia, while iron deficiency (ID) directly affects its function, disrupting mitochondrial respiration, reducing their contractility and relaxation. Some studies have shown that ID is a predictor of adverse outcomes in patients with acute coronary syndrome (ACS). However, the impact of ID and its treatment, quality of life and prognosis of patients with ID and myocardial infarction (MI) has not been fully established. The study aim is to determine the effectiveness of intravenous ferric carboxymaltose (FCM) compared with oral iron (ferrous sulfate) in relation to left ventricular (LV) systolic function, assessed by echocardiography.Material and methods. This open-label, prospective, randomized study includes 360 patients with or without ID who were hospitalized with acute myocardial infarction (MI). Patients with ID will be randomized (1:1) to intravenous FCM and oral ferrous sulfate therapy. Treatment in groups will be started at the time of hospitalization. Patients without ID will form the control group. The follow-up period for patients will be 1 year. The primary endpoint was a reduction in LV wall motion score index (WMSI) in the FCM group compared to the ferrous sulfate group. The key secondary endpoint is a composite endpoint of cardiovascular death, non-fatal MI and stroke, and hospitalization for decompensated heart failure.Conclusion. The OPERA-MI study will determine the effect of ID treatment with intravenous FCM compared with oral ferrous sulfate on WMSI, which reflects LV systolic function.
Frequency of hemodynamic response to orthostatic stress in heart failure with reduced ejection fraction, associations with clinical blood pressure
Authors: Fedorova D. N. , Soloveva A. E. , Fudim M. , Galenko V. L. , Kozlenok A. V. , Berezina A. V. , Villevalde S. V. 
Published: June 2022

Aim. To assess hemodynamic response to active standing test (AST) with beat-to-beat blood pressure (BP) monitoring, their association with office BP and symptoms of orthostatic intolerance in patients with heart failure (HF).Material and methods. Outpatient HF patients with documented left ventricular ejection fraction <40%, followed up in a HF center and receiving optimal medical therapy, underwent AST with beat-to-beat non-invasive BP monitoring.Hemodynamic response was assessed according to the European Federation of Autonomic Societies criteria.Results. The study included 87 patients (mean age, 57±10 years; men, 76%). Normal hemodynamic response to orthostatic stress was observed in 36 (41,4%) patients. Pathological response prevailed during the first minute of orthostatic stress — initial orthostatic hypotension (OH) (n=29, 33,3%) and delayed BP recovery (n=18, 20,7%). Classical OH was detected in 4 (4,6%) patients. There was no orthostatic hypertension, defined as an increase in systolic BP (SBP) ≥20 mm Hg. According to office BP, hypotension was observed in 19 (21,8%) patients (SBP <90 mm Hg in 4 patients and 90-100 mm Hg in 15), hypertension (SBP >140 mm Hg) in 11 (12,6%) patients. Pathological response to orthostatic stress were more often observed in office SBP >140 mm Hg compared to SBP ≤140 mmHg (90,9% and 53,9%, p=0,020).Orthostatic intolerance was noted in 43 (49,4%) patients and were not associated with the level of office SBP (p=0,398) or pathological responses to orthostatic stress (p=0,758 for initial OH and p=0,248 for delayed BP recovery).Conclusion. The pathological hemodynamic response in AST with beat-to-beat BP monitoring in ambulatory patients with HF is most often represented by initial OH and delayed BP recovery associated with office SBP >140 mmHg. The frequency of symptoms of orthostatic intolerance did not differ between groups depending on the presence of an inadequate response to orthostatic stress.
Impact of Capital Structure on Profitability in the Fertilizer Sector of Pakistan
Authors: Nemati Ali Raza , Majeed Afkar , Syed Mohsin Ali 
Published: June 2022

The present study relates to the impact of capital structure on profitability and the study is focused on the fertilizer sector of Pakistan. This study aims to examine whether the debt and equity financing used for financing operations impacts a company’s profitability in the fertilizer sector of Pakistan. Data from four large companies in the fertilizer sector of Pakistan representing about 89 percent of the market share is used for analysis. Data is collected from published Annual reports of these four companies. Data for eight years from 2006 to 2013 is used for analysis. SPSS is used for analyzing the data and linear regression is applied to generate the results. Regression analysis is used to analyze the relationship between capital structure and the profitability of a company. The output of regression analysis is created in the form of a scatter diagram and tables to interpret the results of the regression. Results suggest that there is no significant relationship between capital structure and profitability of a company in the fertilizer sector of Pakistan. Results also show a significant relationship between current liabilities and the profitability of the company in the fertilizer sector of Pakistan.
JEL Classification Code: E22, G32, M49
DEGRADAÇÃO DO CORPO HÍDRICO NO URBANO EM BOA VISTA– RR
Authors: De Azevedo Farias Maria Valdira , Veras Ana Sibelônia Saldanha , Alves da Paixão Shigeaki Ueki 
Published: June 2022

Resumo
A bacia sedimentar Boa Vista revela, morfologicamente,
características de uma planície com relevo suave e dissecação
localizada e representada por limitados campos arenosos.
Nos estudos do CPRM (1983) a formação Boa Vista está
localizada nos melhores aqüíferos de Roraima, em Boa
Vista. As bacias hidrográficas formadas de acordo com a
movimentação de falhas transcorrentes dextrais depositaram
sedimentos na estruturação do relevo, no traçado atual da
rede de drenagem e do conjunto de lagos. Capital conta com
55 bairros. Dentre eles os da zona oeste, decorrentes do processo
de invasão em terrenos públicos e privados formados
em períodos eleitorais. Áreas ocupadas inadequadamente
geram impactos ambientais que comprometem a sustentabilidade
e refletem a qualidade de vida do homem. As áreas
mais afetadas por precipitações intensas, com inundações,
assoreamento estão ocupadas desordenadamente, e não possuem
saneamento básico. Os procedimentos metodológicos
consistiram em revisão bibliográfica e trabalho de campo que
possibilitou uma melhor condução da pesquisa. O trabalho
constou de etapas de pesquisas bibliográficas, sobre o tema
ambiental, para a interpretação do período atual que nos
faz refletir sobre a situação de inundação presenciada pela
população boavistense, quantidade de volume da água e das
grandes áreas alagadas, pesquisadas no perímetro entre as
coordenadas. O presente artigo tem por objetivo discutir
a relação entre a gestão de recursos hídricos e o exercício
da cidadania em Boa Vista-RR e intensificar campanhas de
sensibilização e de conscientização necessárias a educação,
num esforço sinergético.
Palavras-chave:
Àgua;SustentabilidadeUrbana; Degradação.
EDUCACIÓN SUPERIOR E INTERCULTURALIDAD EN MISIONES-ARGENTINA
Authors: Nuñez Yamila Irupé 
Published: June 2022

El presente artículo es parte de mi tesis de grado, en la cual se intenta describir y analizar las posibilidades y condiciones de acceso al sistema educativo superior por parte de estudiantes guaraníes (Mbya y Avá chiripa), captando las principales difi - cultades que deben enfrentar en su intento por ingresar y permanecer en la institución educativa de la sociedad dominante. Para tal fi n se toma como población objeto a los estudiantes guaraníes que ingresaron a la Facultad de Humanidades y Ciencias Sociales (FHyCS) de la Universidad Nacional de Misiones (UNaM) desde el período 2008 a 2012.
Palavras-chave
capital cultural, relaciones interétnicas, educación intercultural.
EFEITOS CONSOCIATIVOS DO BICAMERALISMO E DA REPRESENTAÇÃO NO CONGRESSO BRASILEIRO**
Authors: Branco Marcello Simão 
Published: June 2022

O artigo discute a questão da desproporcionalidade de representação no Congresso Nacional, com um enfoque não apenas voltado à Câmara dos Deputados, mas que inclui a relação desta com o Senado Federal. A partir da análise do processo legislativo brasileiro realiza-se uma reflexão comparativa sobre as possibilidades de veto às emendas constitucionais na Câmara e no Senado. Através de interpretações que levam em conta a representação tal como ela é e como poderia ser caso a desproporcionalidade na Câmara fosse corrigida, procuramos responder se os resultados poderiam ser diferentes e, com isso, causar impactos sobre as maiorias regionalmente representadas nas duas regiões mais desenvolvidas do país, Sudeste e Sul. Os dados mostram que a desproporcionalidade não é grave e equilibra a representação na federação brasileira, desigual em termos econômicos e populacionais.

Palavras-chave
Representação Legislativa, Bicameralismo, Emendas Constitucionais.
CARACTERIZAÇÃO SOCIOECONÔMICA E ESPACIAL DO SUBCENTRO COMERCIAL DA AVENIDA ATAÍDE TEIVE EM BOA VISTA-RR
Authors: De Azevedo Farias Maria Valdira , Veras Ana Sibelônia Saldanha , Alves da Paixão Shigeaki Ueki 
Published: June 2022

Boa Vista representa uma das cidades mais importantes
do estado de Roraima e, segundo o Plano Diretor (IBAM,
2005), a capital é dividida em quatro zonas (Norte, Sul,
Leste e Oeste) e para o Instituto Brasileiro de Geografia e
Estatística-IBGE, a divisão dá-se em 55 (cinquenta e cinco)
bairros. Assim, o objetivo do presente trabalho consiste
em apresentar o resultado da pesquisa, que se constitui em
conhecer o perfil dos consumidores e dos comerciantes
da Avenida Ataíde Teive e suas adjacências, quanto ao seu
abastecimento e de sua população sem que necessite sair do
local. O aporte teórico focou a teoria abordada por Silva em
Dinâmica Territorial Urbana de Boa Vista-RR, e dados empíricos
do subcentro, compôs-se de análises e interpretações
das informações apuradas, bem como a elaboração de mapas
temáticos ao visitar as empresas. Além disso, procurou-se
detectar potenciais e deficiências e, desta forma, com o diagnóstico
da situação encontrada identificou-se gargalos que
vem minizando o desenvolvimento da área. Constatou-se
que os produtos comercializados são de procedência de estados
do sudeste do país, e que o maior consumidor é cidadão
boavistense, aliado ao setor de serviços – administração pública
(servidor público/contracheque). Concluiu-se que a Av.
Ataíde Teive é carente de melhorias, tanto de infraestrutura
como sinalização, estacionamento, policiamento, bem como
na implementação de suas mercadorias, fachadas modernas,
capacitação de colaboradores, dentre outros aspectos.
Palavras-chave:
Avenida Ataíde Teive Boa Vista (Roraima); Relações de
Comércio-consumidores;subcentro; espaço urbano.
“FRONTEIRAS INTERNAS” DA AMÉRICA DO SUL: REFLEXÕES PRELIMINARES SOBRE O ESTADO PERUANO NA CONFIGURAÇÃO DO IMEDIATO PÓS-GUERRA FRIA
Authors: De Lyra Junior Américo Alves 
Published: June 2022

O presente artigo discuti o fim da ordem internacional da Guerra Fria e as pautas emergentes para as novas agendas inter¬nacionais do século XXI. Nesse proces¬so, observam-se as configurações dos atores internacionais nos cenários global e regional. No tocante ao último cenário, vislumbra-se a América do Sul que se reordenou a partir de Estados com “má¬quinas” aperfeiçoadas ou não. Essa divisão permite criação de “fronteiras interna” que revelam como países reagiram diante das mudanças mundiais. O caso peruano é o objeto de investigação central, com os esforços governamentais para adequar a nação à realidade imposta pela globali¬zação. Esforços que não lograram efeitos plenamente positivos, tendo-se fenômenos como a ocorrência do narcotráfico nesse país.
Palavras-Chave:
Guerra Fria; Peru; Estados Modernos.
Outcome study of proximal femur fracture in patients having cardiac diseases
Authors: Singh Khushwinder , Mahindra Pankaj , Garg Rajnish 
Published: June 2022

To assess the outcome of fracture in patients with cardiac diseases, evaluate delay in surgery & study the quality of life post hospital discharge.A prospective review of the medical records of 32 cases who underwent surgery at Dayanand Medical college & Hospital, Ludhiana was performed. Patients were selected with proximal femur fracture having cardiac diseases after fulfilling the inclusion and exclusion criteria. After taking detailed history and examination, the patients were followed up after 4-6 weeks and 3-4 months. A detailed structured performa was filled and functional assessment was done using HHS.We had final follow up of all 32 patients which were included in the study managed by PFN. Modified HHS was accessed at 4-6 weeks and 3-4 months and found to be 41.19 (SD =12.89) & 64.66 (SD =13.35) respectively. No mortality was observed during the follow up. Presence of cardiac comorbidities increased the chances of hip fracture and poor HHS was observed among the patients in the study. Although no significant difference on HHS was observed among the subtypes of cardiac diseases. Most common cause of delay in surgery was the use of antiplatelet agents and delay in surgery affected the HHS significantly in a way that more the delay, poor was the HHS. Presence of comorbidities like hypertension, diabetes mellitus decreased the mean HHS. Occurrence of complications also affected the HHS. More the complications, poor was the HHS.Patients with hip fracture with a diagnosis of CVD, have greater risk of hip fracture with longer length of hospital stay and hence higher cost per hospital stay. Presence of more comorbidities along with CVD shows a significant association in the functional outcome.
Short-term functional outcomes of anatomic single-bundle ACL reconstruction using modified I.D.E.A.L technique
Authors: Rasul Barham M. , Fatah Rebar M. Noori 
Published: June 2022

To achieve a satisfactory knee function and successful return to sports activities in patients with an ACL injury, it is essential to accurately reproduce the native ligament anatomy and biomechanics by placing the graft in the anatomical position within the ACL footprint. Our objectives are to investigate the short-term functional outcomes of an anatomic single-bundle reconstruction using the modified I.D.E.A.L technique of femoral tunnel placement, with 1-year follow-up.A retrospective observational study of 120 patients who developed ACL rupture and underwent anatomic single-bundle reconstruction in TUY MALIK private hospital/ Sulaymaniyah city/Iraq from March 2020 till March 2022. The functional outcomes of the procedure were assessed using the subjective knee evaluation scores (IKDC, Lysholm, and Tegner scores) preoperative and 1-year postoperatively.The mean preoperative IKDC score was 50.96 (40.22- 60.91), and 1-year postoperative score was 83.81 (72.41-95.40), with a (p-value 0.000), whereas the mean Lysholm score was 51.17 (40-67) and 86.19 (75-95) preoperative and postoperative, respectively, with a (p-value 0.000). The mean Tegner score was 7.59 preinjury, while 3.63 before the operation and 7.18 after the operation with (p-value 0.000), representing a statistically significant enhancement in functional outcomes between preoperative and final clinical follow-up assessment.Reconstructing ACL anatomically by placing the graft in the modified I.D.E.A.L position within the native femoral footprint can reestablish near-normal knee biomechanics, obtain unrestricted knee range of motion, and successful return to preinjury activity level.
Comparison of functional outcomes for displaced extra-articular distal radius fractures managed by operative and non-operative methods: A prospective cohort study
Authors: Nazeer Muhammed , Nazeer Muhammed Ehsan , Kamath Jagannath , Shetty Harshit , Maheshan Harish , Jain Manesh Kumar 
Published: June 2022

: Fractures of the distal radius are one of the most common injuries seen in our day-to-day practice. It accounts for almost 4% of the injuries seen in the emergency department. Despite its high incidence and the substantial possible implications of suboptimal management, no high-level evidence regarding the best treatment method yet exists. The study aimed to compare the functional outcomes of extra articular distal radius fractures managed operatively with those managed conservatively. In this prospective cohort study conducted between November 2018 to September 2020, 18 to 65 years old patients with displaced extraarticular distal radial fracture were treated surgically or conservatively. DASH and Modified Mayo Wrist Score were calculated after a follow up of one year.: At the end of 12 months the patients were evaluated, and it was noticed that patients who were treated operatively had significantly better functional and clinical outcomes, as indicated by significantly higher Mayo scores than patients treated conservatively by casting (all p values &#60; 0.05). The DASH scores were lower in the patients who had undergone operative management. Patients treated with volar plate fixation were able to resume activities of daily living few weeks earlier compared to those managed with K-wire fixation and conservative group. Therefore, we can conclude that volar plate fixation gives significantly better clinical and functional results than other methods of treatment.
To evaluate the role of VAC therapy in open fractures after primary fixation in term of faster and more effective wound healing
Authors: Verma Ashutosh , Patel Jaydeep , Saroj Atul Kumar , Kumar Shailesh , Agarwal Sudhanshu , Yadav Atul 
Published: June 2022

Vacuum-assisted closure (VAC) is a noninvasive, active wound management system that exposes a wound bed to local sub atmospheric pressure, removes fluid from the extravascular space, improves circulation, and enhances the proliferation of granulation tissue. The purpose of this study is to know the rate of wound infection, number of days required for making the wound fit for skin cover procedures, number of days required for formation of uniform granulation tissue bed in the wound healing treated by Vacuum Assisted Closure after primary fixation of fracture.Patients between 18 to 60 years were included in this prospective randomized controlled trial. Primary internal Fixation of fracture was done as soon as possible followed by VAC application. Functional outcome of cases recorded during each follow up according to Johner and Wruh’s (1983).According to this study, 30 patients with open fractures of both bone leg after primary internal fixation with VAC application. During follow up effective decrease (mean ± SD) in wound size after VAC therapy was 9.97±9.59 cm2 with P-value 0.0481. This technique has resulted in the effective decrease in wound size, infection and give a better functional outcome.The greatest advantage of VAC was found to facilitate rapid formation of granulation tissue on wounds with exposed tendons, bones, raw area wounds and exposed implants hence decrease healing time and minimize soft tissue defect coverage procedures.
The Ethos of God and Man in the Christos Yannaras’ Works
Authors: Leśniewski Krzysztof 
Published: June 2022

Etos Boga i człowieka w twórczości Christosa Yannarasa
Objawienie prawdy o Bogu jako Trójcy ma bezpośredni wpływ na tożsamość i kondycję osoby ludzkiej. Bycie osobą jest nierozerwalnie związane z etosem. Niniejszy artykuł analizuje istotę etosu Boga w odniesieniu do tradycji chrześcijańskiej i etosu osoby ludzkiej stworzonej na obraz i podobieństwo Boże na podstawie myśli teologicznej znanego prawosławnego myśliciela religijnego — Christosa Yannarasa (ur. 1935). Prawda o tym, że Bóg działa w sposób osobowy, jest bardzo ważnym założeniem dla zrozumienia osobowej tożsamości i etosu człowieka. Jedynie w relacji do Boga, który jest Trójcą Przenajświętszych Osób, nasz ludzki etos może być wolny od zwodniczej wizji egzystencjalnej samonegacji oraz indywidualistycznej etyki i moralności.