bluuebunny/crossref_metadata_2025_split huggingface dataset:
Recurrent pulmonary infection leads to the diagnosis of triple A syndrome: a case report
Authors: Ali Sawssan , Murad M. Subhi , Hamdan Humam , Nakawa Wael 
Published: July 2022

Abstract
Introduction

Triple A syndrome is a very uncommon disease marked by a triad of adrenocorticotrophic hormone (ACTH)—resistant features: adrenal insufficiency, alacrimia, and achalasia. It presents in several clinical forms with undetermined incidence and shows an autosomal pattern of inheritance. It is caused by a variety of mutations in the AAAS genes which encode a protein of unknown function called ALADIN. Diagnosis depends on clinical manifestations, laboratory test results, imaging and endoscopic findings, and Schirmer’s test. The treatment includes artificial tears, glucocorticoid replacement therapy, and treatment of achalasia.

Case presentation
A 12-year-old Syrian girl was referred to Damascus University’s Children’s Hospital for recurrent pulmonary infection. Her mother had noted an absence of tears when crying since birth, diffused pigmentations since birth, especially on the cheeks and genitals, recurrent vomiting of both solid and liquid foods, and recurrent exacerbations of bronchitis and recurrent pneumonia. ACTH and blood cortisol levels indicated an adrenal insufficiency, chest computed tomography and barium swallow test results indicated achalasia, tear break-up time as well as eye examination indicated alacrimia, which led to the diagnosis of triple A syndrome. Treatment included Heller cardiomyotomy, artificial tears, and hydrocortisone (15–30 mg/m2), as well as continuous observation of ACTH levels.

Discussion
Triple A syndrome (which is characterized by the triad of achalasia, alacrima, adrenal insufficiency) is a rare multisystem disease. It has a genetic background and is potentially fatal. This syndrome is often misdiagnosed, especially in regions where it is expected to have a high prevalence rate (regions with documented cases and high rate of consanguinous marriage), This study is the first documentation of triple A syndrome in Syria, a country where consanguineous marriage is common. This syndrome should be kept in mind when a child presents with one or more of its characteristic features.
Carbon-enriched organic amendments differently affect the soil chemical, biological properties and plant biomass in a cultivation time-dependent manner
Authors: Holatko J. , Hammerschmiedt T. , Mustafa A. , Kintl A. , Radziemska M. , Baltazar T. , Jaskulska I. , Malicek O. , Latal O. , Brtnicky M. 
Published: July 2022

Abstract
Background
The farmyard manure application maintains quality of arable soils, provides nutrients, mitigates climate change by soil carbon sequestration. Biochar and other complex carbon rich amendments may stabilize organic matter derived by composting and decelerate organic carbon mineralization. However, how the combined utilization of biochar, humic substances and manure effects on soil chemical and biological properties have been least explored, especially their effect on soil basal and substrate induced respirations are needed to be further explored. Therefore, the potential of biochar and Humac (a commercial humic substances product) in combination with manure to improve the soil properties and plant growth was investigated in this experiment using barley under a short-term (12 weeks) and maize under long-term (following 12 weeks, a total of 24 weeks) cultivation.

Results
In the early phase of cultivation (12 weeks) Humac- or biochar-enriched manures (M + H, M + B, respectively) enhanced the contents of nutrient elements (carbon + 5.6% and + 7%, nitrogen + 6.7% and − 5%, sulphur − 7.9% and + 18.4%), the activity of enzymes including (β-glucosidase + 32% and + 9.6%, phosphatase + 11% and 6.3%), and dry aboveground biomass (+ 21% and + 32%), compared to the control and manure-treated soil. However, these impacts of M + H and M + B manures were reduced under longer period, i.e., at the experiment end (24 weeks). After 24 weeks of cultivation, a decrease in absolute values of all determined enzyme activities indicated putative reduction of mineralization rate due to presumed higher recalcitrance of manure-derived organic matter, with Humac, biochar amendments. Increased stability of soil organic matter reduced microbial activity due to lower availability of nutrients. Possibly, the shortened period of manure maturation could help preserve a higher amount of less degraded organic matter in the enriched manures to counteract these observed features.

Conclusions
We summarized that the biochar and humic substances combined with manure have the potential to improve the soil characteristics, plant biomass and soil health indicators but the improvements faded away in a cultivation time-dependent manner. Further studies are required to explore the structure and functioning of microbial activities under long-term experimental conditions.

Graphical abstract
AYA ‘Can-Sleep’ programme: protocol for a stepped-care, cognitive behavioural therapy-based approach to the management of sleep difficulties in adolescents and young adults with cancer
Authors: Vaughan Emma , Ftanou Maria , Lewin Jeremy , Murnane Andrew , Berger Ilana , Wiley Joshua F. , Hickey Martha , Bullen Dani , Jefford Michael , Goldin Jeremy , Stonehouse Jeremy , Thompson Kate 
Published: July 2022

Abstract
Background
Sleep problems are reported in up to 50% of adolescents and young adults (AYA) with cancer. Cognitive behavioural therapy for insomnia (CBTi) is considered the gold-standard treatment. In the AYA population, CBTi is associated with improvements in insomnia, daytime sleepiness, fatigue and quality of life. In adults, stepped-care interventions can improve accessibility to CBTi. This study aims to evaluate the acceptability and feasibility of a stepped-care CBTi programme in AYA with cancer.

Methods and analysis
AYA (target N = 80) aged 16–25 with a diagnosis of cancer will be screened using the Insomnia Severity Index (ISI) and Epworth Sleepiness Scale (ESS). When sleep difficulties are identified by the ISI and/or ESS, they will be screened for obstructive sleep apnoea and restless leg syndrome and referred to a sleep service if indicated. The remainder with sleep difficulties will be offered a stepped-care sleep programme including CBT self-management and coaching (first step). Participants will then be rescreened at 5 weeks, and those with ongoing sleep difficulties will be offered individualised CBT (second step). Recruitment and retention rates, adherence to intervention and time taken to deliver screening and intervention will be collected to assess the feasibility of the programme. AYA and clinicians will complete evaluation surveys to assess the acceptability of the AYA Can-Sleep programme.

Discussion
We seek to contribute to the evidence base regarding screening and treatment of sleep difficulties in the AYA population by implementing the AYA Can-Sleep programme and determining its feasibility and acceptability as an approach to care in an Adolescent & Young Adult Cancer Service.
Attenuation of hemodynamic response to laryngoscopy and endotracheal intubation with single dose dexmedetomidine in controlled hypertensive patients: prospective randomized double-blind study
Authors: Ismail Eman Ahmed , Mostafa Ahmed Abdelrahman , Abdelatif Mohamed M. 
Published: July 2022

Abstract
Background
Laryngoscopy and endotracheal intubation may be associated with adverse events as hypertension, tachycardia, and increased serum concentrations of catecholamines. These events are serious in patients with cardiac diseases or hypertension. This work was designed to assess the effects of single dose dexmedetomidine on hemodynamic response to endotracheal intubation in controlled hypertensive patients.

Methods
Seventy patients were randomly assigned into two equal groups; dexmed group received intravenous dexmedetomidine 0.5 mcg/kg diluted to 20 ml with 0.9% sodium chloride and control group received 20 ml of 0.9% sodium chloride. Changes in heart rate, systolic, diastolic, and mean blood pressures were recorded in both groups at baseline, after 5 min of study drug infusion, 3 min after induction and prior to intubation, 1 min after intubation, 3 min after intubation, and 5 min after intubation.

Results
Dexmed group had a significantly lower heart rate, systolic blood pressure, diastolic blood pressure, and mean blood pressure at 1 min, 3 min, and 5 min after intubation.

Conclusions
Single dose dexmedetomidine attenuated the hemodynamic response to laryngoscopy and intubation in controlled hypertensive patients.

Trial registration
ClinicalTrial.Gov (NCT03204006) (March2018).
Protective and therapeutic potentials of HDL and ApoA1 in COVID-19 elderly and chronic illness patients
Authors: AbdelHafez Mohamed Aly 
Published: July 2022

Abstract
Background
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for coronavirus disease-2019 (COVID-19). Elderly subjects, obese, and patients with chronic illnesses, are the most affected group. HDL has pleiotropic physiological functions that are affected with alteration(s) in its structure.

Main text
Inflammation whether septic, immune, or other affects HDL structure and function. COVID-19 is associated with systemic immune-inflammation due to cytokine surge. Viral interaction with erythrocytes and hemoglobin-related compounds (may cause anemia and hypoxia) and other factors may affect HDL function. Trials have been conducted to resume HDL functions using peptide preparation, nutritional, and herbal elements.

Conclusions
In this review article, I’ll discuss the use of reconstituted HDL (rHDL), Apo-A1 mimetic peptide D-4F, ω-3 polyunsaturated fatty acids, and the powdered roots and/or extract of Saussurea lappa (costus) to avoid comorbidity and mortality of COVID-19 in patients with chronic illness or elderly-age mortality.
Assessing supermarket patronage in Matola, Mozambique
Authors: McCordic Cameron , Frayne Bruce , Sunu Naomi 
Published: July 2022

AbstractAs an indicator of a potential broader nutrition transition, the supermarketization of urban food systems in the Global South has become a growing area of research interest. While the rising dominance of supermarkets in urban food systems has been noted in several global cities in the Global South, there have been fewer investigations into the spatial and demographic characteristics that may govern the patronage of supermarkets in smaller secondary cities. This paper assesses this supermarketization trend via an investigation of supermarket patronage in a secondary city through a 2014 household survey of Matola, Mozambique (n = 507). Using a combination of descriptive statistics and decision tree learning algorithms, the findings suggest a strong geographic pattern to supermarket patronage among the surveyed households in Matola. Further analyses comparing frequent and infrequent supermarket patrons confirms the observation that spatial distance may be a more significant determinant of supermarket patronage than household wealth among the surveyed households in Matola. These findings suggest that the spatial availability of supermarkets may play a greater role in defining the supermarketization of Matola’s food system than household entitlements. These findings also have implications for the evolving concept of urban food deserts in secondary cities, recognizing the role of spatial location in determining household access to supermarkets.
Barriers and enablers to implementing and using clinical decision support systems for chronic diseases: a qualitative systematic review and meta-aggregation
Authors: Chen Winnie , O’Bryan Claire Maree , Gorham Gillian , Howard Kirsten , Balasubramanya Bhavya , Coffey Patrick , Abeyaratne Asanga , Cass Alan 
Published: July 2022

AbstractBackgroundClinical decision support (CDS) is increasingly used to facilitate chronic disease care. Despite increased availability of electronic health records and the ongoing development of new CDS technologies, uptake of CDS into routine clinical settings is inconsistent. This qualitative systematic review seeks to synthesise healthcare provider experiences of CDS—exploring the barriers and enablers to implementing, using, evaluating, and sustaining chronic disease CDS systems.MethodsA search was conducted in Medline, CINAHL, APA PsychInfo, EconLit, and Web of Science from 2011 to 2021. Primary research studies incorporating qualitative findings were included if they targeted healthcare providers and studied a relevant chronic disease CDS intervention. Relevant CDS interventions were electronic health record-based and addressed one or more of the following chronic diseases: cardiovascular disease, diabetes, chronic kidney disease, hypertension, and hypercholesterolaemia. Qualitative findings were synthesised using a meta-aggregative approach.ResultsThirty-three primary research articles were included in this qualitative systematic review. Meta-aggregation of qualitative data revealed 177 findings and 29 categories, which were aggregated into 8 synthesised findings. The synthesised findings related to clinical context, user, external context, and technical factors affecting CDS uptake. Key barriers to uptake included CDS systems that were simplistic, had limited clinical applicability in multimorbidity, and integrated poorly into existing workflows. Enablers to successful CDS interventions included perceived usefulness in providing relevant clinical knowledge and structured chronic disease care; user confidence gained through training and post training follow-up; external contexts comprised of strong clinical champions, allocated personnel, and technical support; and CDS technical features that are both highly functional, and attractive.ConclusionThis systematic review explored healthcare provider experiences, focussing on barriers and enablers to CDS use for chronic diseases. The results provide an evidence-base for designing, implementing, and sustaining future CDS systems. Based on the findings from this review, we highlight actionable steps for practice and future research.Trial registrationPROSPEROCRD42020203716
Advanced Vesicular Systems for Antifungal Drug Delivery
Authors: Mosallam Shaimaa , Albash Rofida , Abdelbari Manar Adel 
Published: July 2022

AbstractFungal infections are considered one of the most serious conditions as their occurrence has increased lately. Fungi like Candida, Fusarium, and Aspergillus species mostly affect immunocompromised patients as they are considered opportunistic pathogens. These infections can be superficial, cutaneous, subcutaneous, or systemic fungal infections that require specific treatment. There is a wide variety of antifungal drugs that can be used to cure fungal infections; however, most of them have many systemic side effects due to their physicochemical characteristics and high toxicity profile. Hence, the current review focuses on various advanced vesicular carriers with high biocompatibility that can encapsulate the antifungal drugs owing to increase their efficacy and limit the undesirable side effects. These advanced systems can manage stability, solubility, bioavailability, safety, and effectiveness issues present in conventional systems.
Από χώρα σε χώρα: αντιξοότητες και ομαλή προσαρμογή. Εμπειρίες παιδιών προσφύγων
Authors: Γρηγορόπουλος Ηρακλής , Ντόβα Μαρία 
Published: July 2022

Σκοπός της παρούσας έρευνας ήταν η διερεύνηση των αντιξοοτήτων που αντιμετώπισαν ή/και συνεχίζουν να αντιμετωπίζουν τα συμμετέχοντα παιδιά και των παραγόντων εκείνων που (για τα ίδια) λειτούργησαν ή/και συνεχίζουν να λειτουργούν ως παράγοντες ομαλής προσαρμογής (προστατευτικοί παράγοντες- ψυχική ανθεκτικότητα). Η κατανόηση της εμπειρίας του κάθε μεμονωμένου πρόσφυγα είναι ιδιαίτερα σημαντική για τον σχεδιασμό των υπηρεσιών (όχι μόνο υγείας) στο πλαίσιο που ακολουθεί τη φυγή. Χρησιμοποιήθηκε ποιοτική μεθοδολογία. Συμμετείχαν 15 μαθητές/τριες (επτά κορίτσια) από πρόγραμμα ένταξης στο Ελληνικό δημοτικό σχολείο σε περιοχή της κεντρικής Μακεδονίας. Η ηλικία τους κυμαινόταν από τα 6 έως τα 12 έτη. Η συλλογή δεδομένων πραγματοποιήθηκε με ημιδομημένες συνεντεύξεις και η επεξεργασία τους με βάση την Ερμηνευτική Φαινομενολογική Ανάλυση (IPA). Από τη συστηματική ανάλυση των αφηγήσεων προέκυψαν 3 κεντρικές θεματικές και οι υπο-θεματικές τους , οι οποίες οδηγούν στη νοηματοδότηση της εμπειρίας των παιδιών που συμμετείχαν. Συνολικά, η ανάλυση των δεδομένων ανέδειξε το γεγονός ότι η μετακίνηση σε μια νέα χώρα υπέβαλε τα παιδιά της συγκεκριμένης έρευνας σε πιεστικά γεγονότα για την αντιμετώπιση των οποίων σημαντικό ρόλο έπαιξε η αξιοποίηση των προσωπικών τους δυνατοτήτων.
UJI KANDUNGAN FORMALIN PADA AYAM BROILER YANG DI JUAL DI PASAR TRADISIONAL DAN PASAR MODERN DI WILAYAH DEPOK SLEMAN YOGYAKARTA
Authors: Kristiani Eva Runi , Febriani Heni , Franklin Quezia 
Published: July 2022

Ayam merupakan salah satu sumber protein hewani yang banyak dikonsumsi masyarakat dan sangat dibutuhkan sebagai sumber gizi untuk kesehatan masyarakat, produk tersebut menjadi berbahaya bagi kesehatan masyarakat bila tidak terjamin keamanannya seperti penggunaan bahan tambahan (kima dan alami) untuk pengawet, termasuk formalin. Penelitian ini bertujuan untuk mengetahui ada tidaknya kandungan formalin pada ayam broiler yang dijual dipasar tradisional dan pasar modern di wilayah Depok, Sleman, Yogyakarta. Jenis Penelitian yang digunakan adalah penelitian eksperimental dengan pendekatan Â deskriptif. Pelaksanaanya dilakukan di Laboratorium STIKES Wira Husada Yogyakarta. Sampel diambil dengan metodeÂ teknikÂ cluser random sampling. Jumlah sampel yang diambil sebanyak 27 sampel dari pasar tradisional dan pasar modern wilayah Depok Sleman Yogyakarta. Sampel kemudian dianalisi menggunakan reagen FeCL3. Hasil penelitian menunjukan bahwa 6 dari 27 sampel ayam broiler tersebut positif mengandung formalin.Â Kata Kunci: Analisis Kualitatif, Formalin, Ayam broiler.
PENERAPAN PRINSIP HIGIENE SANITASI DENGAN KEBERADAAN HAZARD BIOLOGIS PADA PERALATAN DI KANTIN UNIVERSITAS
Authors: Musfirah Musfirah , Rahayu Atikah , Agustin Helfi 
Published: July 2022

Cafetaria in university must meet the nutritious and healthy snacks for students. The quality of healthy and nutritious food is influenced by hygienic, good sanitation and free-hazard contamination aspects on the canteen management. Poor sanitation and hygiene utensils and storage management can increase food contamination.This study aimed to determine the association of implementation of food and hygiene sanitation with the biological hazard on eating utensils. This study used cross-sectional design and was conducted in May 2017. The number of canteen sample were 9 canteen and 15 food handlers. The data were collected by microbiological quality checks on tableware and cookware which were often used by the food handlers in food management, observation sheet of sanitary conditions of eating utensils, and questionnaires to find out the implementation of food sanitation hygiene in the canteen. The analytical statistic method used Fisher test. The results study indicate the implementation of hygiene sanitation principle was not associated with the existence of biological hazard of germs in tableware (p = 0,538) and cookware (p = 0,476) variable. Knowledge and practice of food safety needs to be increased through training on food security and food sanitation hygiene among food handlers.
Chondrosarcoma patient characteristics, management, and outcomes based on over 5,000 cases from the National Cancer Database (NCDB)
Authors: Ottesen Taylor D. , Shultz Blake N. , Munger Alana M. , Amick Michael , Toombs Courtney S. , Friedaender Gary E. , Grauer Jonathan N. 
Published: July 2022

Introduction
Chondrosarcoma, although relatively uncommon, represents a significant percentage of primary osseous tumors. Nonetheless, there are few large-cohort, longitudinal studies of long-term survival and treatment outcomes of chondrosarcoma patients and none using the National Cancer Database (NCDB).

Methods
Chondrosarcoma patients were identified from the 2004–2015 NCDB datasets and divided on three primary tumor sites: appendicular, axial, and other. Demographic, treatment, and long-term survival data were determined for each group. Multivariate Cox analysis and Kaplan-Meier survival curves were generated to assess long-term survival over time for each.

Results
In total, 5,329 chondrosarcoma patients were identified, of which 2,686 were appendicular and 1,616 were axial. Survival was higher among the appendicular cohort than axial at 1-year, 5-year, and 10-year (89.52%, 75.76%, and 65.24%, respectively). Multivariate Cox analysis identified patients in the appendicular cohort to have significantly greater likelihood of death with increasing age category, distant metastases at presentation, and male sex (p<0.001 for each). Best outcomes for seen for those undergoing surgical treatment (p<0.001). Patients in the axial cohort were with increased likelihood of death with increasing age category and distant metastases (p<0.001), while surgical treatment with or without radiation were associated with a significant decrease (p<0.001). Kaplan-Meier survival analysis showed worst survival for the axial cohort (p<0.001) and patients with distant metastases at presentation (p<0.001). Survival was not significantly different between older (2004–2007) and more recent years (2012–2016) (p = 0.742).

Conclusions
For both appendicular and axial chondrosarcomas, surgical treatment remains the mainstay of treatment due to its continued superiority for the long-term survival of patients, although advancements in survival over the last decade have been insignificant. Presence of distant metastases and axial involvement are significant, poor prognostic factors perhaps because of difficulty in surgical excision or extent of disease.
Effects of transcutaneous tibial nerve stimulation on females with overactive bladder syndrome in multiple sclerosis a protocol for a systematic review and meta-analysis
Authors: Tu Huan , Li Ning , Liu Wanna , Fan Zhonghe , Kong Dezhi 
Published: July 2022

Background
Overactive bladder (OAB) is a problem that increasingly affects adults and the elderly, especially women. It may affect quality of life, ability to participate and overall wellbeing. Transcutaneous tibial nerve stimulation (TTNS) is a form of neuromodulation involving the use of electrical impulses to address urinary symptoms. There are many randomized controlled trials that have shown that TTNS is effective at treating overactive bladder. In recent years, TTNS has gained increasing attention for this condition. But its effect in females remains controversial and evidence is lacking. Therefore, the main purpose of this study will be to systematically evaluate the effect of TTNS on females with OAB in Multiple sclerosis (MS) by conducting a systematic review and meta-analysis, and also to provide a reference for the application of TTNS in OAB.

Methods
A systematic review of eligible articles will be conducted using Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA) guidelines. A comprehensive search of the literature will be conducted in PubMed, Web of Science, The Cochrane Library, Chinese National Knowledge Infrastructure Database (CNKI), Wanfang Data, Weipu Electronics, and other databases. We will include randomized controlled trials about TTNS in females with OAB in MS. Two reviewers will screen titles, abstracts, and full texts independently. We will use a hierarchy of recommended assessment, development, and assessment methods to assess the overall certainty of the evidence and report findings accordingly. Endnote X9 will be used to select the studies and Review Manager V.5.4 (Cochrane Collaboration) will be used to conduct the meta-analysis. The mean difference or standard deviation with 95% confidence interval (CI) will be used in the computation of continuous variables to synthesize data.

Results
The results will provide evidence for judging whether TTNS is effective in females with OAB and MS.

Conclusion
This study will provide reliable evidence for the effect of TTNS in female patients with OAB and MS.

Trial registration
Systematic review registration: PROSPERO CRD42021256861.