bluuebunny/crossref_metadata_2025_split huggingface dataset:
Computational analysis of missense filamin-A variants, including the novel p.Arg484Gln variant of two brothers with periventricular nodular heterotopia
Authors: Gerlevik Umut , Saygı Ceren , Cangül Hakan , Kutlu Aslı , Çaralan Erdal Fırat , Topçu Yasemin , Özören Nesrin , Sezerman Osman Uğur 
Published: May 2022

BackgroundPeriventricular nodular heterotopia (PNH) is a cell migration disorder associated with mutations in Filamin-A (FLNA) gene on chromosome X. Majority of the individuals with PNH-associatedFLNAmutations are female whereas liveborn males withFLNAmutations are very rare. Fetal viability of the males seems to depend on the severity of the variant. Splicing or severe truncations presumed loss of function of the protein product, lead to male lethality and only partial-loss-of-function variants are reported in surviving males. Those variants mostly manifest milder clinical phenotypes in females and thus avoid detection of the disease in females.MethodsWe describe a novel p.Arg484Gln variant in theFLNAgene by performing whole exome analysis on the index case, his one affected brother and his healthy non-consanguineous parents. The transmission of PNH from a clinically asymptomatic mother to two sons is reported in a fully penetrant classical X-linked dominant mode. The variant was verified via Sanger sequencing. Additionally, we investigated the impact of missense mutations reported in affected males on the FLNa protein structure, dynamics and interactions by performing molecular dynamics (MD) simulations to examine the disease etiology and possible compensative mechanisms allowing survival of the males.ResultsWe observed that p.Arg484Gln disrupts the FLNa by altering its structural and dynamical properties including the flexibility of certain regions, interactions within the protein, and conformational landscape of FLNa. However, these impacts existed for only a part the MD trajectories and highly similar patterns observed in the other 12 mutations reported in the liveborn males validated this mechanism.ConclusionIt is concluded that the variants seen in the liveborn males result in transient pathogenic effects, rather than persistent impairments. By this way, the protein could retain its function occasionally and results in the survival of the males besides causing the disease.
Attitudes and acceptability of children, caregivers, and healthcare providers about using telemedicine for pediatric HIV care in a resource-limited setting
Authors: Manglani Mamta , Lala Mamatha Murad , Gabhale Yashwant , Balakrishnan Sudha , Bhuyan Khanindra , Rewari B. B. , Setia Maninder Singh 
Published: May 2022

Background
The Pediatric HIV Telemedicine Initiative is a video-linked delivery of expert services, designed to reach those previously unable to access expert HIV care. The present qualitative study was designed to understand the acceptability of telemedicine [TM] by patients, their caregivers and health care providers in the anti-retroviral therapy (ART) centers in Maharashtra.

Methods
We conducted focus group discussions with caregivers at six ART centres (three linked with TM facilities and three not linked with TM). We also conducted in-depth interviews with medical officers, counselors, and pharmacists at each centre. The data from the interviews were transcribed and translated into English for analysis. The qualitative data were analyzed using thematic framework approach.

Results
Children and caregivers who had participated in telemedicine consultation through video conference found the process acceptable, were comfortable communicating during these sessions, and did not have any specific problem to report. The advantages of TM were: consultation without having to travel to other cities; economic advantage; and prompt consultation. The total time spent during the process and technical difficulties during the TM sessions were some of the challenges. The medical officers had the opportunity to discuss difficult cases with the expert during the TM session. Some sessions were also considered a ’group counseling’ session, wherein several children and caregivers were able to interact and learn from each other and motivate each other. The health care providers at the three centers that did not currently have TM facilities expressed a desire to have these services at their centers as well. According to them, these facilities will help them address complicated and difficult pediatric HIV cases. Currently, they send their patients to referral centers or other hospitals. Since, many of these referral hospitals are situated in bigger cities, less than 50% of patients access care at these centers This is mostly due to the time constraints and finances (travel/stay) required for accessing these centres.

Discussion
TM was a feasible, acceptable, and desired approach for care of children living with HIV/AIDS. It provides support to their caregivers as well as their care providers. The ART staff from the telemedicine-linked peripheral centers were supportive of the use of TM and wanted these services to be initiated in the non-linked centers.
Dandy Style: 250 Years of British Men’s Fashion, Shaun Cole and Miles Lambert (eds) (2021)
Authors: Crookendale Carla-Mae 
Published: May 2022

Review of: Dandy Style: 250 Years of British Men’s Fashion, Shaun Cole and Miles Lambert (eds) (2021)
New Haven, CT: Yale University Press, 168 pp.,
ISBN 978-0-30025-413-6, h/bk, $35.00
Determination of the type and the length for the transition curves on the directions of high-speed train operation
Authors: Kurhan Mykola , Kurhan Dmytro , Husak Marina , Hmelevska Nelya 
Published: May 2022

In many countries around the world, a cubic parabola is used as transition curves in a simplified form. Today, the properties of many mathematical curves are well studied, which can be used as transition curves. The object of research is the process of restructuring transition curves when organizing high-speed trains operation. The use of modern means of mathematical modelling allows to add a number of dynamic characteristics for evaluation parameters of motion in the curved sections of the tracks. Thus, with an increase in speed for transition curves, both the values of unbalanced acceleration and its change in time, and also the velocity attenuation of oscillations of rolling stock when moving from a transition curve to a circular curve or to a direct section. On the basis of the conducted research, it has been found that when increasing the speed of the vehicle movement in the range from 120 to 200 km/h, the length of the stabilization section increases at the output of the curvature by an average of 20 m for every 40 km/h. The analysis showed that with correctly set parameters of transition curves, which correspond to the maximum speed of movement and radius of a circular curve, the strength and reliability of the bearing elements in the structure of the permanent way and the travel comfort are fully ensured.
Preparation of soybean dreg fiber solid emulsifier and its effect on the stability of Pickering emulsion
Authors: Zhang Ying , Duan Fangyu , Fang Jiaqi , Lu Jiahong , Wang Jinyu , Zhang Jiarui , Gao Junpeng , Yu Hansong , Fan Hongliang 
Published: May 2022

Abstract
High purity insoluble dietary fiber (HPIDF) was extracted from Okara by compound enzyme method, and solid emulsifiers with different particle sizes were prepared by wet grinding. Its composition, structure and physicochemical properties were studied, and the influence mechanism of solid emulsifiers with different particle sizes on emulsifying properties and interface stability of Pickering emulsion was systematically studied. The results showed that the particle size of HPIDF decreased significantly, the ζ-potential, contact Angle and swelling capacity of HPIDF ncrease significantly (p < 0.05). HPIDF forms an adsorption layer at the oil-water interface, and some of them are connected to form a bridge network structure, which plays a role of steric hindrance. And the emulsion has excellent stability under different environmental factors. HPIDF are suitable raw materials as natural food-grade solid emulsifiers. It is cost-effective and eco-friendly to realize the high-value utilization of Okara resources, reduce resource waste, and extend the industrial chain.
The modified Rusanov scheme for solving the phonon-Bose model
Authors: Mohamed Kamel , Abdelrahman Mahmoud A. E. 
Published: May 2022

Abstract
This paper considers the one-dimensional model of heat conduction in solids at low temperature, the so called phonon-Bose model. The nonlinear model consists of a conservation equation for the energy density e and the heat flux Q with ∣Q∣ < e. We present a simple and accurate class of finite volume schemes for numerical simulation of heat flow in arteries. This scheme consists of predictor and corrector steps, the predictor step contains a parameter of control of the numerical diffusion of the scheme, which modulate by using limiter theory and Riemann invariant, the corrector step recovers the balance conservation equation, the scheme can compute the numerical flux corresponding the real state of solution without relying on Riemann problem solvers and it can thus be turned to order 1 in the regions where the flow has a strong variation and to order 2 in the regions where the flow is regular. The numerical test cases demonstrate high resolution of the proposed finite volume scheme (modified Rusanov) and confirm its capability to provide accurate simulations for heat flow under flow regimes with strong shocks.
Effects of complementary spiritual therapy on stress, anxiety, burnout syndrome and hematological parameters of professionals in a public hospital: a randomized controlled trial
Authors: Carneiro Élida Mara , Avezum Oliveira Livia Figueira , Alves da Silva Djalma Alexandre , da Silva Catarino Jonatas , Timóteo Rodolfo Pessato , Desidério Chamberttan Souza , Rodrigues Junior Virmondes , de Fátima Borges Maria 
Published: May 2022

Abstract

Objectives
This randomized controlled trial evaluated the stress, anxiety, and burnout of professionals exposed to complementary spiritist therapy (CST), which consists in therapeutic resources as prayer, Spiritist passe, fluidic water and spiritual education or control.

Methods
Seventy-six professionals were randomized to CST or control: to maintain the routine for 5 weeks. The ISSL scale, anxiety and depression Beck’s indices, Maslach instrument, subjective well-being and WHOQOL-BREF were used at baseline and five-week. Blood count and cytokine dosage were collected at baseline, one-week and five-week. Analysis using the intention to treat approach.

Results
The means of variation of stress (exhaustion phase) between baseline and five-week were −1.50 ± 3.31 in the CST and 0.72 ± 3.50 in the control (p=0.036), effect size for CST group was d=0.65, which is considered medium effect. CST showed decrease in emotional exhaustion and negative affects, and increase in lymphocytes, erythrocyte parameters and platelets between the baseline and five-week (p<0.05). Reduction in IL-1β and increase in total lymphocyte count were observed with 2–3 sessions per week, but that does not maintain when the number of sessions is decreased. Participants receiving ≥7 sessions reduced emotional exhaustion, depersonalization and stress, and improved hematological parameters throughout the study (p<0.05).

Conclusions
CST may be effective in reducing stress (exhaustion phase) compared to control. Higher frequency of interventions promotes better psychic state, evidenced by large effect size for emotional exhaustion in burnout, and improves hematological parameters of professionals.
Does the use of chitosan covered gauze for postpartum hemorrhage reduce the need for surgical therapy including hysterectomy? A databased historical cohort study
Authors: Biele Carolin , Radtke Laura , Kaufner Lutz , Hinkson Larry , Braun Thorsten , Henrich Wolfgang , Dückelmann Anna M. 
Published: May 2022

Abstract

Objectives
Postpartum hemorrhage (PPH) is still one of the leading causes of maternal mortality worldwide. Recently effective PPH therapy with uterine packing with the chitosan-covered gauze was shown. This databased retrospective case–control study compares the therapy success of the chitosan tamponade with that of the balloon tamponade and medical therapy only.

Methods
All women who delivered at a university hospital between May 2016 and May 2019 with PPH were included. Based on the applied therapy, women were divided into three groups: medical therapy only, balloon tamponade and chitosan tamponade. The groups were compared in terms of therapy success, side-effects and reasons for PPH. Primary outcome was the need for surgical/radiological measures including hysterectomy, secondary outcomes were differences in hemoglobin levels, duration of inpatient stay, admission to intensive care unit, number of administered blood products and inflammation parameters.

Results
A total of 666 women were included in the study. 530 received medical therapy only, 51 the balloon tamponade and 85 the chitosan tamponade. There were no significant differences in the need for surgical therapy, but a significantly lower number of hysterectomies in the chitosan tamponade group than in the balloon tamponade group. There were no relevant differences in secondary outcomes and no adverse events related to the chitosan tamponade. Since the introduction of chitosan tamponade, the number of PPH related hysterectomies dropped significantly by 77.8%.

Conclusions
The chitosan tamponade is a promising treatment option for PPH. It reduces the postpartum hysterectomy rate without increased side effects compared to the balloon tamponade.
Synthesis of composite membranes from polyacrylonitrile/carbon resorcinol/formaldehyde xerogels: gamma effect study, characterization and ultrafiltration of salted oily wastewater
Authors: Awadallah-F Ahmed , Hefni Hassan H. H. , Awadallah Ahmed E. , Badr Emad A. , Badr Magd M. 
Published: May 2022

Abstract
The subsequent activated carbons of resorcinol-formaldehyde xerogels are synthesized and exposed to wide range of gamma irradiation dose. Xerogels and their subsequent activated carbons are characterized by diverse techniques; FTIR, Raman, porosity analysis, SEM, EDX and AFM. The composite membranes are fabricated from polyacrylonitrile and activated carbon xerogels as composite membranes to be utilized in ultrafiltration process of salted oily wastewater. The soybean oil is exploited as organic feeding solution. The results declared that values of flux and rejection reach 157 (L m−2 h−1) and 99.8 (%), respectively. Overall, the best performing composite membrane is conducted by maximizing pure water flux. The optimally synthesized membrane performs well for purification of salted oily wastewater, and a significant increment in permeate flux is obtained with soybean oil rejection is at ∼99.8% and with maximum flux is at 32 (L m−2 h−1). Further, the composite membranes showed good promise for ultrafiltration of salted oily wastewater.
Technical-Tactical Demands of 3 × 3 International Basketball Games According to Game Outcome, Player Sex, and Competition Phase
Authors: Ferioli Davide , Conte Daniele , Scanlan Aaron T. , Vaquera Alejandro 
Published: May 2022

Abstract
Ferioli, D, Conte, D, Scanlan, AT, and Vaquera, A. Technical-tactical demands of 3 × 3 international basketball games according to game outcome, player sex, and competition phase. J Strength Cond Res 37(2): 403–412, 2023—Despite the popularity of 3 × 3 basketball rapidly growing on a global scale, a paucity of data exist on player demands during competition, particularly considering various factors. This study aimed to quantify the technical-tactical demands of international-level 3 × 3 basketball games according to game outcome, player sex, and competition phase. Overall, 96 players from 24 national teams (48 players across 12 teams in each sex) competing at the 2019 European Basketball Cup 3 × 3 were included in this study. Technical-tactical demands during games including shooting, game-related, and possession-related statistics were retrospectively gathered from public sources or analyzed using video analyses. Linear mixed models and effect size analyses were used to determine differences in demands according to game outcome (wins vs. losses), player sex (males vs. females), and competition phase (group games vs. finals games). Winning teams (p < 0.05, small-large) scored more shots, shot more efficiently, secured more rebounds, committed fewer turnovers and fouls, and drew more fouls to shoot free-throws. Differences between sexes (p < 0.05, small-moderate) showed male teams shot more efficiently, scored more 2-point shots, and scored more points, whereas female teams attempted more 1-point shots, committed more turnovers, and had more possessions. Considering the competition phase, more blocks were completed during group games, and more points per possession were achieved during finals games (p < 0.05, small). This study provides foundation normative values regarding the technical-tactical demands of 3 × 3 game-play during an international competition, with reported data able to be used by practitioners in developing precise, sex-specific training and tactical strategies to optimize team success.
The Effect of Stress on Semantic Memory Retrieval: A Multiverse Analysis
Authors: Heyman Tom , Boere Robin , de Jong Sebastiaan , Hoogeterp Lotte , Kraaijenbrink Joyce , Kuipers Charlotte , van Dijk Martijn , van Rijn Lotte , van Wijk Twan 
Published: May 2022

Stress is often associated with negative consequences, and this also applies in the context of memory retrieval. However, Smith, Hughes, et al. (2019) proposed that this relationship only holds for information stored in episodic memory, because it relies on the hippocampus. In contrast, conceptual knowledge is stored in semantic memory, which is associated with neocortical and striatal brain regions that are upregulated during stress. Indeed, Smith, Hughes, et al. (2019) found that people experiencing acute psychosocial stress performed better on a subsequent trivia questionnaire compared to a control group. Moreover, performance correlated positively with cortisol reactivity. These findings are important, novel, and perhaps somewhat surprising, hence it is important to establish their generalizability. The latter is accomplished in the present study through a multiverse analysis. The results showed that the effect is relatively robust to variations in the scoring rules for the trivia questionnaire, the type of statistical model being used, and the inclusion versus exclusion of gender as a covariate in the analyses. However, we obtained mostly null effects when using the change in psychological stress levels as a predictor variable, and/or when only considering questions that were actually answered. The latter finding in particular is worrisome as it might point to alternative explanations. That is, stress might improve performance, because participants are more engaged with the task or are more prone to guess, regardless of its (potential) impact on semantic memory retrieval. Hence, it is premature to conclude that stress enhances semantic memory.
Į besimokantįjį orientuotas mokytojų ir švietimo pagalbos specialistų ugdymas, taikant personalizuotą mokymąsi
Authors: Ališauskienė Stefanija 
Published: May 2022

Straipsnyje su skaitytojais dalijamasi pagrindiniais rezultatais, pasiektais kuriant, diegiant ir išbandant inovatyvią personalizuotu mokymusi grįstą pedagogų rengimo praktiką. Ši praktika sukurta ir įgyvendinta bendradarbiaujant Lietuvos pedagogų ugdymo centrams - Vilniaus universiteto Šiaulių akademija, Vilniaus universitetu ir Vytauto Didžiojo universitetu, bei Islandijos universitetu ir Korko universitetu Airijoje[1]. Šiame straipsnyje dalijamasi pagrindiniais pasiekimais, susijusiais su sukurta personalizuotu mokymusi grindžiamo pedagogų ugdymo koncepcija bei šios koncepcijos pagrindu atnaujintomis pedagogų rengimo studijų programomis, taip pat su įdiegtos pedagogų ugdymo studijų programose personalizuotu mokymusi grindžiamos koncepcijos raiška. Šio tyrimo metodologija grindžiama antrine duomenų analize bei projekto INTERPEARL[2] pasiekimų ataskaitų analizę. INTERPEARL projekto metu įgytos žinios ir patirtis patvirtina prielaidą, kad į besimokantįjį orientuotoje paradigmoje mokytojo vaidmuo keičiasi, bet tampa kitaip svarbus. Mokytojas labiau veikia kaip pagalbininkas, taikydamas lankstų mokymosi tempą ir diferencijuotą vertinimo praktiką, o ne tiesiogiai perteikia žinias. Kartu su kitais aktualiais klausimais į besimokantįjį orientuotame mokymosi procese svarbiausi yra du aspektai: gebėjimas parinkti ir pasirinkti veiklą bei tinkamus vertinimo metodus, taip pat besimokančiojo gebėjimas prisiimti atsakomybę už savo mokymąsi, darantis didelę įtaką mokymosi pasiekimams

[1] KA203 – Strateginės partnerystės aukštajam mokslui. Projektas INTERPEARL: Inovatyvus mokytojų ugdymas taikant personalizuotą mokymąsi 2018-1-LT01-KA203-046979
Clinical Decision Support for Newborn Weight Loss: A Randomized Controlled Trial
Authors: Flaherman Valerie J. , Robinson Andrew , Creasman Jennifer , McCulloch Charles E. , Paul Ian M. , Pletcher Mark J. 
Published: May 2022

BACKGROUND AND OBJECTIVE
The Newborn Weight Tool (NEWT) can inform newborn feeding decisions and might reduce health care utilization by preventing excess weight loss. Clinical decision support (CDS) displaying NEWT might facilitate its use. Our study’s objective is to determine the effect of CDS displaying NEWT on feeding and health care utilization.

METHODS
At an hospital involved in NEWT development, we randomly assigned 2682 healthy infants born ≥36 weeks gestation in 2018–2019 either to CDS displaying NEWT with an electronic flag if most recent weight was ≥75th weight loss centile or to a control of usual care with NEWT accessed at clinician discretion. Our primary outcome was feeding type concordant with weight loss, defined as exclusive breastfeeding for those not flagged, exclusive breastfeeding or supplementation for those flagged once, and supplementation for those flagged more than once. Secondary outcomes included inpatient and outpatient utilization in the first 30 days. We used χ2 and Student’s t tests to compare intervention infants with control and to compare trial infants with those born in 2017.

RESULTS
Feeding was concordant with for 1854 (74.5%) trial infants and did not differ between randomized groups (P = .65); concordant feeding was higher for all trial infants than for infants born in 2017 (64.4%; P &lt; .0005). Readmission occurred for 51 (3.8%) CDS infants and 45 (3.4%) control infants (P = .56). Among the 60% of trial infants with outpatient records available, there were 3.5 ± 1.7 visits with no differences between randomized groups (P = .10).

CONCLUSIONS
At an hospital involved in NEWT development, CDS displaying NEWT did not alter either feeding or health care utilization compared with discretionary NEWT access.