bluuebunny/crossref_metadata_2025_split huggingface dataset:
The normative and Jural meanings of the anti‐deprivation principle vis‐à‐vis freedom of contract
Authors: Vaccari Eugenio 
Published: March 2022

AbstractContracts and clauses negotiated by the parties with the objective purpose of depriving the debtor of assets upon insolvency contravene the collective, mandatory nature of insolvency procedures and, consequently, the anti‐deprivation principle. This article provides a theoretical conceptualisation of the normative meaning of the anti‐deprivation principle by marking its separation from the principle of freedom of contract. If willingly and consistently applied by courts, this conceptualisation could provide enhanced predictability regarding the use of the anti‐deprivation principle in insolvency cases.
Di‐ and trioxides of triazolotetrazine: Computational prediction of crystal structures and estimation of physicochemical characteristics
Authors: Khakimov Dmitry V. , Zelenov Victor P. , Pivina Tatyana S. 
Published: March 2022

AbstractSimulation of crystal structures of series 1(2)‐R‐1(2)H‐[1,2,3]triazolo[4,5‐e][1,2,3,4]tetrazine 5,7‐dioxides, 1,5,7‐trioxides, 4,6‐dioxides and 3,4,6‐trioxides was carried out using an original technique based on the method of atom‐atom potentials and quantum chemistry. The effect of the position of the substituent in the triazole ring on the change in the crystal structures of these compounds and their thermochemical characteristics was studied for the first time. For some of synthesized compounds, thermochemical characteristics were investigated and differential scanning calorimetry curves were obtained. Detonation parameters were calculated, on the basis of which the prospects for the use of the considered compounds were assessed.
Controlling growth of phototrophic biofilms on limestone using CaZn2(OH)6·2H2O and ZnO nanoparticles
Authors: Lázaro‐Mass Stephania , De la Rosa‐García Susana , García‐Solis Claudia , Reyes‐Trujeque Javier , Soria‐Castro Montserrat , Fuentes Antonio F. , Quintana Patricia , Gómez‐Cornelio Sergio 
Published: March 2022

AbstractBACKGROUNDDeterioration by microbial activity is common in the built cultural heritage, where phototrophic microorganisms are primary colonizers that form complex communities associated with heterotrophic microorganisms. Therefore, this article analyses the antiphototrophic effect of ZnO and CaZn2(OH)6·2H2O (CZ) nanoparticles (NPs) on three limestone lithotype coupons (Xcambo, red limestone and shellstone). The nanomaterials were obtained via sol–gel (SG), hydrothermal (HT) and mechanochemical (MS) routes and characterized using powder X‐ray diffraction and scanning electron microscopy. Two concentrations of NPs (5000 and 10 000 μg mL−1) were applied to the coupons; afterwards, phototrophic microorganisms isolated from Chichén‐Itzá, Yucatan were inoculated. The percentage of protection was calculated with ImageJ software, and chromatic parameters were measured to identify visible changes in the stones.RESULTSThe results show differences in the protective effect and color variations depending on the nanomaterials and phototrophic microorganisms applied in the limestone coupons. CZ and ZnO protect more than 72% on the surface of shellstone and Xcambo except for ZnO‐SG in shellstone. The growth of Gloeocapsa sp. in red limestone with ZnO‐SG and CZ‐SG was equal to or greater than that of the control without NPs. In general, the NPs protect the limestone surface against phototrophic microorganisms up to 10% more than commercial algaecide. The coupons treated with ZnO‐HT and CZ‐HT have greater protection against biofilm formation than other coatings.CONCLUSIONSIn general, the coatings show a higher antiphototrophic protection than the controls, mainly the CZ‐HT coatings, with better results at lower concentration. Therefore, these nanomaterials could be used to inhibit the formation of biofilms on built cultural heritage. © 2022 Society of Chemical Industry (SCI).
Social media use, professional behaviors online, and perceptions toward e‐professionalism among dental students
Authors: Kamarudin Yasmin , Mohd Nor Nor Azlida , Libamin Ann Carnelian , Suriani Ameerah Nur Hidayah , Marhazlinda Jamaludin , Bramantoro Taufan , Ramadhani Aulia , Neville Patricia 
Published: March 2022

AbstractObjectivesThis study aimed to assess self‐reported social media use, professional behaviors online, and perceptions on e‐professionalism while using social media among dental students in two Southeast Asian universities.MethodsThis cross‐sectional study involved clinical dental students at University of Malaya (UM), Malaysia (n = 150) and Airlangga University (AU), Indonesia (n = 150). A questionnaire was distributed using Google Form via WhatsApp network. Data were analyzed using descriptive, Chi‐square, and Wilcoxon rank‐sum tests.ResultsAll students responded (n = 300) and reported as active social media users. Majority spent ≥ 1 h a day on social media and checked their social media > 6 times a day. Most commonly used social media accounts were Instagram (UM: 92.7%, AU: 95.3%) and Facebook (UM: 94.7%, AU: 59.3%). A small proportion of UM and AU students admitted to posting clinical photographs, patient records, and comments about patients on social media. UM students had significantly better scores in terms of their professionalism behaviors on maintaining the integrity of the profession compared to AU students (p < 0.001). Meanwhile AU students had better scores than UM students on behaviors related to upholding colleagues’ professional image on social media (p = 0.421). Most students in UM and AU shared similar positive perceptions toward online professionalism behavior statements. Majority reported concerns over unprofessional posts online.ConclusionSelf‐reported behaviors online sometimes contradict with students’ perceptions and concerns about being unprofessional online. There is a need for clearer educational guidelines on how to instill e‐professionalism values and behaviors among dental students.
New laboratory evidence for the association between endothelial dysfunction and COVID‐19 disease progression
Authors: Liu Nan , Long Hui , Sun Jianhua , Li Huan , He Yunting , Wang Qiang , Pan Kai , Tong Yongliang , Wang Bingshun , Wu Qingming , Gong Likun 
Published: March 2022

AbstractThere is growing evidence that angiotensin‐converting enzyme 2 is highly expressed on endothelial cells, endothelial dysfunction plays a critical role in coronavirus disease 2019 (COVID‐19) progression, but laboratory evidence is still lacking. This study established a multicenter retrospective cohort of 966 COVID‐19 patients from three hospitals in Wuhan, China. We found that male (62.8% vs. 46.5%), old age [72 (17) vs. 60.5 (21)], and coexisting chronic diseases (88.5% vs. 60.0%) were associated with poor clinical prognosis in COVID‐19. Furthermore, the deteriorated patients exhibited more severe multiorgan damage, coagulation dysfunction, and extensive inflammation. Additionally, a cross‐sectional study including 41 non‐COVID‐19 controls and 39 COVID‐19 patients assayed endothelial function parameters in plasma and showed that COVID‐19 patients exhibited elevated vascular cell adhesion molecule‐1 (VCAM‐1) (median [IQR]: 0.32 [0.27] vs. 0.17 [0.11] μg/ml, p < 0.001), E‐selectin (21.06 [12.60] vs. 11.01 [4.63] ng/ml, p < 0.001), tissue‐type plasminogen activator (tPA) (0.22 [0.12] vs. 0.09 [0.04] ng/ml, p < 0.001), and decreased plasminogen activator inhibitor‐1 (0.75 [1.31] vs 6.20 [5.34] ng/ml, p < 0.001), as compared to normal controls. Moreover, VCAM‐1 was positively correlated with
d‐dimer (R = 0.544, p < 0.001); tPA was positively correlated with
d‐dimer (R = 0.800, p < 0.001) and blood urea nitrogen (R = 0.638, p < 0.001). Our findings further confirm the strong association between endothelial dysfunction and poor prognosis of COVID‐19, which offers a rationale for targeting endothelial dysfunction as a therapeutic strategy for COVID‐19.
Variation of floret development and grain setting characteristics in winter wheat responses to delayed sowing
Authors: Zhu Yuangang , Zhang Xiu , Xiao Yanyan , Chu Jinpeng , Dai Zhongmin 
Published: March 2022

AbstractBACKGROUNDWheat floret development has been a focus of research due to a desire to improve spike fertility, which majorly influences grain yield. Sowing date plays a vital role on grain yield in wheat, and increase in the grain number per spike of winter wheat (Triticum aestivum L.) has been obtained by delayed sowing. During the 2014–2015 and 2015–2016 growing seasons, variation in these developmental patterns was explored involving two winter wheat cultivars (Jimai 22 and Tainong 18) and five sowing dates (24 September; 1, 8, 15 and 22 October).RESULTSWe noticed clear differences in the grain number per spikelet; delayed sowing had a greater impact on the number of fertile florets at anthesis than grain set. Significant differences in the developmental patterns of florets among spikelet positions corresponded to variations in the floret developmental rate, with faster floret development associated with higher floret fertility. Delayed sowing did not affect the grain number near the rachis, but significantly promoted grain set on distal florets. Increased spike dry weight (SDW) did not compensate for floret size or grain weight, mainly due to enhanced assimilate partitioning to florets.CONCLUSIONDelayed sowing significantly affects floret developmental dynamics, causing differences in winter wheat floret fertility. An increased SDW concomitant with improved intra‐spike partitioning before anthesis contributes to increase the distal floret numbers per spike and then optimize winter wheat spike fertility. © 2022 Society of Chemical Industry.
Supercritical fluid chromatography with post‐column addition of supporting electrolyte solution for electrochemical determination of tocopherol and tocotrienol isomers
Authors: Yamamoto Kazuhiro , Nishimura Takuma , Machida Koichi , Kotani Akira , Hakamata Hideki 
Published: March 2022

A supercritical fluid chromatography with electrochemical detection system was developed for the simultaneous determination of tocopherol and tocotrienol isomers. The supercritical fluid chromatography with electrochemical detection system was connected with an additional pump to create a flow path to add a supporting electrolyte solution. The supporting electrolyte solution was mixed with a mobile phase in a post‐column fashion, enabling the independent control of the separation and detection. After optimization of the measurement conditions, vitamin E isomers and an internal standard substance (2,2,5,7,8‐pentamethyl‐6‐hydroxychroman) were separated within 30 min using a mixture of supercritical carbon dioxide and methanol (99:1, v/v) as a mobile phase and a cyanopropyl column (4.6 mm inner diameter × 250 mm length, 5 μm). For the electrochemical detection, methanol containing 1.0 mol/L ammonium acetate was used as a supporting electrolyte solution, and the applied potential was set at +0.8 V. This analytical method showed good linearity (5–100 μg/mL) and repeatability (less than 2.5% relative standard deviation, n = 6) and was applicable to the determination of tocopherol and tocotrienol isomers in nutrition supplements.
A sensitive and selective HPLC–MS3 method for therapeutic drug monitoring of meropenem and its validation by comparison with HPLC–MS2 methods
Authors: Cao Haiwei , Yin Lei , Cao Haihuan , Guo Haiyang , Ren Wenbo , Li Yanyan , Huang Jing 
Published: March 2022

Meropenem, a representative β‐lactam antibiotic, is widely used to treat complicated and serious infections. Therefore, it is of great significance to monitor the plasma drug concentration for individualized antimicrobial therapy. This study first describes the development and validation of high‐performance liquid chromatography–tandem mass spectrometry cubed method for monitoring meropenem in human plasma. Protein precipitation with methanol and a chromatographic analysis time of 7 min make this method simple and of high throughput. Meropenem was extracted from human plasma with recoveries >94.1%. Calibration curves were linear (R2 > 0.995) in the concentration range of 0.5–50 μg/mL. Overall accuracy and precision did not exceed 8.0% as well as no significant matrix effect was observed. The novelty of this method is that the triple‐stage mass spectrometry technology improves the selectivity and sensitivity. A comparison of the presented method and traditional liquid chromatography–tandem mass spectrometry method was assessed in 44 patients treated with meropenem and Passing–Bablok regression coefficients and Bland–Altman plots showed that no significant difference between the two methods. So the triple‐stage mass spectrometry method developed in this study is appropriate and practical for the monitor of meropenem in the daily clinical laboratory practice.
The nosographic structure of posttraumatic stress symptoms across trauma types: An exploratory network analysis approach
Authors: Ferreira Filipa , Gysi Deisy , Castro Daniel , Ferreira Tiago Bento 
Published: March 2022

AbstractThe nosographic structure of posttraumatic stress disorder (PTSD) remains unclear, and attempts to determine its symptomatic organization have been unsatisfactory. Several explanations have been suggested, and the impact of trauma type is receiving increasing attention. As little is known about the differential impact trauma type in the nosographic structure of PTSD, we explored the nosology of PTSD and the effect of trauma type on its symptomatic organization. We reanalyzed five cross‐sectional psychopathological networks involving different trauma types, encompassing a broad range of traumatic events in veterans, war‐related trauma in veterans, sexual abuse, terrorist attacks, and various traumatic events in refugees. The weighted topological overlap was used to estimate the networks and attribute weights to their links. Coexpression differential network analysis was used to identify the common and specific network structures of the connections across different trauma types and to determine the importance of symptoms across the networks. We found a set of symptoms with more common connections with other symptoms, suggesting that these might constitute the prototypical nosographic structure of PTSD. We also found a set of symptoms that had a high number of specific connections with other symptoms; these connections varied according to trauma type. The importance of symptoms across the common and specific networks was ascertained. The present findings offer new insights into the symptomatic organization of PTSD and support previous research on the impact of trauma type on the nosology of this disorder.
Endonasal Acoustic Doppler Sonography in Predicting the Survival of Nasoseptal Flap Following Previous Irradiation
Authors: Lai Calvin Chee‐Fung , Chow Samuel Man‐Wai , Tong Michael Chi‐Fai 
Published: March 2022

ObjectiveBlood supply to the nasoseptal flap may be compromised in patients who had previous irradiation to the head and neck region, hence, affecting its viability. Here, we evaluate the role of an endonasal acoustic Doppler sonography in predicting the survival of the nasoseptal flap in this group of patients.Study DesignRetrospective cohort.MethodsRetrospective review of patients with previous irradiation to the head and neck region who had undergone endoscopic endonasal surgeries requiring nasoseptal flap as reconstruction. Survival rates of nasoseptal flap were compared between groups where endonasal Doppler was used.ResultsA total of 28 patients were identified with previous irradiation to the head and neck region who had undergone endoscopic endonasal surgeries requiring nasoseptal flap as reconstruction. The overall survival rate of nasoseptal flap is 67.8% (19 out of 28). Endonasal acoustic Doppler was used in 17 of these patients, of which 13 patients had a positive signal. The flap survival rate in the Doppler‐positive group compared to the non‐Doppler group was significantly better at 100% vs 45.4% (P = .003). Among those where the endonasal Doppler was used, the flap survival rate with a negative doppler signal was significantly worse at 25%, compared with 100% flap survival in those with positive doppler signal (P = .006). The positive predictive value of a positive endonasal Doppler signal with flap survival is 100%.ConclusionThe use of endonasal acoustic Doppler may be useful in predicting the viability of nasoseptal flap in postirradiated patients who need a local mucosal flap coverage.Level of Evidence3 Laryngoscope, 133:244–247, 2023
Comparing the M.D. Anderson Symptom and Dysphagia Inventories for Head and Neck Cancer Patients
Authors: Yarschenko Adam H. , Yannitsos Demetra H. , Weppler Sarah , Barbera Lisa , Quon Harvey , Sun Qiao , Smith Wendy 
Published: March 2022

ObjectivesWhere patient‐reported outcome measures (PROMs) may be administered at multiple patient visits, it is advantageous to capture these symptoms with as few questions as possible. In this study, the M.D. Anderson Head and Neck Symptom Inventory (MDASI‐HN), and the M.D. Anderson Dysphagia Inventory (MDADI) is compared to determine if using the MDASI‐HN alone would overlook symptoms identified with MDADI.MethodsThe MDASI‐HN and the MDADI were completed by 156 patients, postradiotherapy for head and neck cancer (HNC). Associations between the two instruments were analyzed using correlation analysis, unsupervised machine learning, and sensitivity analysis.ResultsLittle correlation was found between the two surveys; however, there was overlap between MDASI‐HN dry mouth and many MDADI items, confirming that dry mouth is an important factor in difficulty swallowing, and patient QoL. Taking longer to eat (MDADI), was the most commonly reported item overall, with 85 (54%) patients rating it as moderate–severe. Dry mouth was the most endorsed MDASI‐HN item (68, 44%). There were 51 patients missed by the MDASI‐HN, reporting no moderate–severe symptoms, but reported one or more moderate–severe QoL impacts on MDADI. If patients who reported a score of 2 or higher on the MDASI‐HN Dry Mouth item are flagged as requiring follow‐up, the number of patients missed by MDASI‐HN drops to 15.ConclusionIn an HNC clinic where MDASI‐HN is routinely administered, assessment of symptoms and QoL might be enhanced by reducing the value at which MDASI Dry Mouth is considered moderate–severe to 2.Level of Evidence3 Laryngoscope, 132:2388–2395, 2022
Biomimetic Biomaterials Based on Polysaccharides: Recent Progress and Future Perspectives
Authors: Silva Rodrigo Duarte , de Carvalho Layde Teixeira , de Moraes Rodolfo Minto , Medeiros Simone de Fátima , Lacerda Talita Martins 
Published: March 2022

AbstractNature is a source of diverse materials, including polysaccharides, which have been used to improve the quality of life. Besides being abundant and renewable, polysaccharides possess many advantages, such as biodegradability and biocompatibility, which allow them to be applied in different fields. They can be used in the design and development of renewable materials, thus contributing to a more sustainable society. Because of their advantages and versatility, polysaccharides may be incorporated in many systems, particularly biomimetic ones, to create outstanding sustainable solutions to problems that still need to be solved. Hence, nature not only offers resources but an inspiration to overcome issues. In this sense, this work aims to present an overview of current relevant biomimetic systems based on polysaccharides. Chitosan, cellulose, xanthan gum, alginates, pullulan, hyaluronic acid, schizophyllan, and oligomeric cyclodextrins are covered. The application of these polysaccharides in the design of biosensors, systems for environmental remediation, structural materials, drug delivery systems, tissue engineering among others is described. Finally, the challenges that still need to be faced and opportunities of application of these materials for the development of bioinspired technologies in the next future are highlighted.
Hierarchically Chiral Nanostructures Self‐Assembled from Nanoparticle Tethered Block Copolymers
Authors: Zhao Hongmeng , Xu Zhanwen , Lin Jiaping 
Published: March 2022

AbstractChiral nanostructures of nanoparticle assemblies have attracted tremendous interest for their fascinating functional properties. Herein, through theoretical simulations, it is shown that nanoparticle tethered block copolymers can self‐assemble into hierarchically chiral nanostructures. Twofold helices are formed in the hierarchically chiral nanostructures: the diblock copolymers form helical supercylinders while the nanoparticles arrange into chiral assemblies wrapped around the helical supercylinders. The hierarchically chiral nanostructures can be formed in a large parameter window. Circular dichroism calculations demonstrate that the coexistence of polymeric helices and chiral nanoparticle assemblies improves the chiroptical activity. These findings can provide guidelines for designing hierarchically ordered chiral nanostructures with advanced functional properties.
Flame‐Retardant PEDOT:PSS/LDHs/Leather Flexible Strain Sensor for Human Motion Detection
Authors: Zong Yan , Tan Sha , Ma Jianzhong 
Published: March 2022

Flexible piezoresistive sensors have demonstrated great potential in human–motion–detection applications. However, it still remains a challenge to fabricate strain sensors with high sensitivity, broad sensing range, and good linear response to strain. In this report, a simple and scalable fabrication strategy is developed to construct high performance strain sensors by using leather as the substrates to filtrate poly(3,4‐ethylenedioxythiophene): poly(4‐styrenesulfonate) (PEDOT:PSS) modified layered double hydroxides (LDHs) suspensions. The naturally aligned collagen fibers in leather enable size selection for the 2D conductive materials and as such dual‐conductive pathways are effectively formed on the surface and in the matrix of leather. Due to the unique design of conductive networks, the prepared sensor possesses high gauge factor (maximum value of 2326.84), tunable strain range (0–70%), fast tensile response time (160 ms), and good stability in 1000 stretching‐relaxing/compression‐relaxing cycles, making it suitable for various human motion detections including coughing and large‐scale motions of joint bending. In addition, the incorporated LDHs is a non‐toxic flame retardant, which is helpful to reduce electronic fire risk and can bring added value to the sensor.
Cationic Conjugated Polyelectrolytes with Aggregation‐Induced Ratiometric Fluorescence
Authors: Mei Li‐Jun , Li Chong , Zhao Peng‐Ju , Chen Tao , Tian Rui , Guo Jing , Zhu Ming‐Qiang 
Published: March 2022

AbstractThe molecular diversity of aggregation‐induced emission remains a challenge due to the limitation of conventional synthesis methods. Here, a series of novel neutral and cationic conjugated polymers composed of various ratios of tetraarylethylene (TAE) containing a bridged oxygen (O) and fluorene (F) units is designed and synthesized via the geminal cross‐coupling (GCC) of 1,1‐dibromoolefins. The incorporation of TAE segments into the conjugated backbone of polyfluorene produces pronounced aggregation‐induced ratiometric fluorescence, i.e., aggregation‐induced emission (AIE) at 520–600 nm and grows synergistically with aggregations‐caused quenching (ACQ) at 400–450 nm. The content of fluorene unit in the polymer backbones determines the intensity of the initial fluorescence in the blue light region. The huge distinction (about 150 nm) in dual emission wavelengths caused by the environment change makes these conjugated polyelectrolytes particularly suitable for ratiometric fluorescence sensing. Based on electrostatic interaction mechanism, the gradual addition of heparin into the cationic conjugated polymers aqueous solutions can induce dual‐color fluorescence changes with a detection limit of 9 × 10−9 m. This work exhibits the great facility of using GCC reaction to synthesis the conjugated TAE polymers with superior AIE properties and special functions.