bluuebunny/crossref_metadata_2025_split huggingface dataset:
A new case of the Myth of the Given?
Authors: Kalpokas Daniel E. 
Published: June 2022

AbstractFor some years now, an increasing number of philosophers have been holding that what is given in perception are the physical objects of our surroundings. This is the view called, among others names, “the Relational View”. Basically, this view consists in the claim that experience is not representational, it is not a matter of the subject's taking things in the world to be this or that way; rather, it is just a matter of being presented with things, of being in a certain kind of relation with them, which makes them available to us, nevertheless, to be represented in judgement or belief. The question arises, however, whether this does not imply a new fall into the Myth of the Given. In this article, I argue for an affirmative response to that question.
Radiographic appearance of a caudal vertebral chordoma in a domestic ferret (Mustela putorius furo)
Authors: Whittaker Claire PJ , Losada‐Medina Daniela , Desprez Isabelle , Sukut Sally 
Published: June 2022

AbstractA 7‐year‐old spayed female ferret was presented to the Veterinary Teaching Hospital at the Western College of Veterinary Medicine for a slow‐growing mass involving the base of the tail. Radiographs revealed a large, irregularly marginated mineralized mass centered on the fifth to seventh caudal vertebrae with osteolysis of the affected caudal vertebrae. A partial caudectomy was performed, and histopathology was consistent with a chordoma. This is the first case report describing the radiographic appearance of a chordoma in the proximal tail and only the second report to describe radiographic findings in a ferret.
Supplemental Material: Mafic magma-driven magmatic processes and compositional variation in granitic pluton construction: The Buya intrusion of West Kunlun, Northwestern China
Authors: Wang C. , al. et 
Published: June 2022

<p>Item A: Methods and Figures S1 and S2. Item B: MCS output data and related illustrations. Table S1: LA-ICP-MS U-Th-Pb isotope data of zircon. Table S2: LA-MC-ICPMS Lu-Hf isotope data of zircon. Table S3: Major- and trace-element analytical data of the Buya pluton. Table S4: Major- and trace-element analytical data of the Buya pluton. </p>
Digital health education: the need for a digitally ready workforce
Authors: Holland Brown Tamsin Mary , Bewick Mike 
Published: June 2022

Digital health education develops an understanding of the pragmatic use of digital technologies, including health apps, artificial intelligence and wearables, in the National Health Service (NHS). Staff should feel confident accessing up-to-date, quality-assured digital health solutions.Digital health is a high priority in government, NHS organisations and Royal Colleges. However, there is a gap between what is expected and the education of staff or medical students to enable implementation.Digital health education needs to be up to date and universally included within training, continuing professional development activities and medical school curriculums.During COVID-19, more families across the UK became digitally enabled with school, council, charities and governments providing access to devices, WiFi and mobile data for those that needed it. Improved digital access brings equalities in access to health information and healthcare professionals. Health app use sharply rose during COVID-19, as patients self-managed and took control of their conditions, but most health apps do not reach NHS standards.Paediatricians are well positioned to advise on appropriate health app use and advocate for improved patient access to solutions.Many paediatricians adopted remote video consultations during the COVID-19 pandemic but could soon adopt more digital health strategies to remotely track, monitor and manage conditions remotely.Patient management now includes remote consultations and digital health solutions; therefore, medical histories should capture digital access, environments and literacy.This article explains the importance of digital health education, lists accessible resources and provides examples of health apps that can be recommended.
Association of direct oral anticoagulant-proton pump inhibitor cotherapy with adverse outcomes: protocol for a population-based cohort study
Authors: Wang Mei , Paterson Michael , Thabane Lehana , Siegal Deborah , Mbuagbaw Lawrence , Targownik Laura , Holbrook Anne 
Published: June 2022

IntroductionProton pump inhibitors (PPIs) are widely used for primary and secondary prevention of upper gastrointestinal bleeding. However, there remains controversy about the overall net clinical benefit of PPIs (omeprazole, rabeprazole, pantoprazole, lansoprazole) when coprescribed with direct oral anticoagulants (DOACs; dabigatran, rivaroxaban, apixaban, edoxaban). Our objective is to explore the risk of clinically relevant events, including bleeding, thromboembolic events and death, in patients prescribed DOACs while taking PPIs versus no PPI.Methods and analysisThe protocol describes a retrospective cohort study of all Ontario residents aged 66 years or older with atrial fibrillation and at least one pharmacy dispensation for a DOAC identified using linked administrative healthcare databases covering 2009–2020. Ontario drug benefit dispensation records will be used to ascertain PPI exposure during DOAC therapy. The primary outcome is a composite of clinically relevant bleeding, thrombotic events or all-cause death. A minimum of 520 patients in total with at least one of the components of the composite outcome are needed. Poisson regression with a generalised estimating equation model will be used to calculate the adjusted incidence rate difference, incidence rate ratios 95% CI, adjusting for propensity for PPI use using inverse probability of treatment weights.Ethics and disseminationThis research is exempt from REB review under section 45 of Ontario’s Personal Health Information Protection Act. We will report our findings in a peer-reviewed biomedical journal and present them at conferences. The study will provide useful evidence to optimise the coprescription of DOACs and PPIs in practice.
Examining endothelial function and carotid artery disease in patients with inflammatory bowel disease: a systematic review protocol
Authors: Wu Hao , Hu Tingzi , Xu Meihua , Hao Hong , Hill Michael A , Xu Canxia , Liu Zhenguo 
Published: June 2022

IntroductionPatients with inflammatory bowel disease (IBD) might be at an increased risk for the development of cardiovascular disease (CVD). The present protocol is developed to review and analyse published data to determine if patients with IBD have an increased CVD burden.Methods and analysisWe will conduct a systematic review of all observational studies that examine endothelial function, arterial stiffness and carotid intima-media thickness in patients with IBD. Study selection will follow the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, and study quality will be assessed using the Newcastle-Ottawa Scale. If sufficient data are available, a meta-analysis will be conducted. The overall effect sizes will be estimated using both fixed effects models and random effects models. Statistical heterogeneity will be calculated using Higgin’s (I2) tests. Subgroup analyses, conditional number of studies retrieved and their sample size, will be stratified according to participant disease category or gender or disease activity.Ethics and disseminationFormal ethics approval is not required as individual data will not be collected. The results will be disseminated through peer-reviewed publications, conference presentations and scientific news releases.PROSPERO registration numberCRD42021274093.
The transition from the classical to the quantum regime for rubidium-87 (87Rb) vapor in terms of the second virial coefficient and the scattering length
Authors: Ajaleen Abeer A. Al , Sandouqa Ayman S. , Ghassib Humam B. 
Published: June 2022

This work focuses on two major properties of 87Rb gas for a very broad temperature range of ∼nK–3000 K. The first is the second virial coefficient B, encompassing both classical ( Bcl) and quantum ( Bq) regimes as well as, in between, the classical coefficient plus the first quantum correction ( Bqcl). The transition from the classical to the quantum regime in this system is explored. The second property is the s-wave scattering length a0 for both singlet [[Formula: see text]] and triplet [[Formula: see text]] states. The medium is incorporated into the picture via the Galitskii–Migdal–Feynman formalism. Its main output is the medium phase shifts for the system, using the “best” available interatomic potential. These are plugged into the Beth–Uhlenbeck formula to give Bq, whereas Bc l and Bqcl are readily calculated from standard expressions, the only input needed being the binary potential. Our results show that Bq exhibits clear demarcation from Bcl, especially at nK temperatures where Bose–Einstein condensation (BEC) manifests itself. Comparison to other calculations in the literature is made only for Bcl; Bq for this gas is computed here for the first time, as are [Formula: see text] and [Formula: see text] for the medium. It turns out that these scattering lengths are larger than their vacuum counterparts at BEC temperatures.
First-principles study of structural, dynamical, elastic, electronic, optical, and thermodynamic properties of Na2ZnSnS4 compound
Authors: Akil Zoheir , Zemouli Mostefa , Boutaleb Habib , Amara Kadda , Khelfaoui Friha , Elkeurti Mohammed 
Published: June 2022

The structural, dynamical, elastic, electronic, optical, and thermodynamic properties for the Na2ZnSnS4 compound is reported using the density functional theory in the framework of the full-potential linearized augmented plane wave method within the Wu and Cohen generalized gradient and Tran–Blaha modified Becke–Johnson approaches. Calculations shows that Na2ZnSnS4 is more stable in the kesterite phase. Phonon studies indicate that this compound is dynamically stable. The elastic constants are calculated and used to confirm the mechanical stability. Moreover, our compound is thermodynamically stable and the conditions of Sn-rich/Na-poor are necessary to form a single-phase Na2ZnSnS4 crystal. The shear modulus, Young’s modulus, Poisson’s ratio, anisotropy factor, Lamé’s constant, and Pugh indicator have also been calculated. The electronic properties shows that Na2ZnSnS4 has a direct gap (Γ–Γ) of 3.18 eV. The optical properties suggests that Na2ZnSnS4 is a good candidate for nonlinear optical applications. The thermodynamic properties such as Debye temperature, thermal expansion coefficient, heat capacities, and entropy are also estimated under temperature and pressure effects.
Kangaroo: Theory and Practice of Caching Billions of Tiny Objects on Flash
Authors: McAllister Sara , Berg Benjamin , Tutuncu-Macias Julian , Yang Juncheng , Gunasekar Sathya , Lu Jimmy , Berger Daniel S. , Beckmann Nathan , Ganger Gregory R. 
Published: June 2022

Many social-media and IoT services have very large working sets consisting of billions of tiny (≈100 B) objects. Large, flash-based caches are important to serving these working sets at acceptable monetary cost. However, caching tiny objects on flash is challenging for two reasons:
(i)
SSDs can read/write data only in multi-KB “pages” that are much larger than a single object, stressing the limited number of times flash can be written; and
(ii)
very few bits per cached object can be kept in DRAM without losing flash’s cost advantage. Unfortunately, existing flash-cache designs fall short of addressing these challenges: write-optimized designs require too much DRAM, and DRAM-optimized designs require too many flash writes.

We present
Kangaroo
, a new flash-cache design that optimizes both DRAM usage and flash writes to maximize cache performance while minimizing cost. Kangaroo combines a large, set-associative cache with a small, log-structured cache. The set-associative cache requires minimal DRAM, while the log-structured cache minimizes Kangaroo’s flash writes. Experiments using traces from Meta and Twitter show that Kangaroo achieves DRAM usage close to the best prior DRAM-optimized design, flash writes close to the best prior write-optimized design, and miss ratios better than both. Kangaroo’s design is Pareto-optimal across a range of allowed write rates, DRAM sizes, and flash sizes, reducing misses by 29% over the state of the art. These results are corroborated by analytical models presented herein and with a test deployment of Kangaroo in a production flash cache at Meta.
A quantificação do trabalho mecânico como recurso de avaliação do controle postural
Authors: Castro Pedro Cláudio Gonsales de , Coelho Daniel Boari , Goroso Daniel Gustavo , Lopes José Augusto Fernandes , Moreira Maria Cecília dos Santos Moreira Cecília dos Santos 
Published: June 2022

O estudo tem por objetivo propor dois métodos de cálculo para a quantificaçao do trabalho mecânico (W) como recurso para análise do controle postural em indivíduos submetidos a perturbaçoes motoras, visuais e/ou que estao em processo de reabilitaçao física. Neste estudo se aborda a quantificaçao do W realizado pelo sistema muscular após a extensao do tronco para postura ereta (auto-perturbaçao) em indivíduos com visao preservada (VP) e privaçao momentânea da visao (PMV) por meio de dois métodos denominados: i) Trabalho mecânico total (Wtot) e ii) Trabalho mecânico do centro de massa (WCM). A amostra constituiu-se de 10 voluntários saudáveis, do sexo masculino com idades de 25,6 (± 2,2) anos. Foram realizadas cinco tentativas para cada voluntário em ambas as condiçoes. Para coleta dos dados foi utilizado um sistema de imagem para rastreamento optoeletrônico tridimensional, composto de 8 câmeras de vídeo, com freqüência de captaçao de 200 Hz. Observou-se pela análise de regressao linear que o Wtot e WCM apresentam forte correlaçao entre as duas condiçoes (r2 = 0,77 para a condiçao VP e r2 = 0,84 para a condiçao PMV) e pelo teste t de Student observou-se diferenças estatisticamente significativas (p<0,10) na primeira tentativa entre os voluntários com VP e PMV para o Wtot durante o intervalo pós-perturbaçao, bem como diferenças no WCM nos intervalos [0,80]ms e [0,100]ms. Concluiu-se que os métodos que calculam o Wtot e o WCM possibilita investigar o controle postural após perturbaçoes motoras e visuais podendo ser utilizado como recurso na reabilitaçao física.
Fear among the elderly of suffering recurring falls: the gait as a determining factor of functional independence
Authors: Rezende Adriana Arruda Barbosa , Silva Iris Lima e , Cardoso Fabrício Bruno , Beresford Heron 
Published: June 2022

This study was carried out with 60 sedentary elderly females, aged between 68 and 70 years and with histories of falls, registered in the “Idoso Feliz” Program in the city of Rio de Janeiro/RJ, and sought to identify the fear of having repeated falls. Initially, an inquiry was done about the occurrence of falls in the group participating in the research. Interviews were then made by means of the Falls Efficacy Scale- International-Brazil to evaluate the group in relation to the concern with falling during the practice of 16 daily activities. Their dynamic gait profile was also evaluated using the Dynamic Gait Index. In relation to the concern by the elderly with falling, 40.11% mentioned no concern, 30% reported some concern, 25.33% moderate concern, and 4.6% were very concerned. The activities for which they showed more concern: taking a bath, walking on slippery or irregular surfaces, walking in a crowded place, and going out to social events. On evaluating the dynamic gait index, the majority of the population had a result considered predictive of falls since most of the elderly scored less than 19 points. It could be concluded that the majority of the investigated population showed at least low or moderate concern for suffering recurrent falls in the practice of everyday life activities, physical activities, and social activities, especially when these require muscular strength and balance. This can be justified, in part, by the unsatisfactory dynamic gait index detected, which implies the presence of abnormalities in that biomechanical function.
Associação entre desempenho funcional e quedas em idosas classificadas segundo a faixa etária
Authors: Amarante Thiago Rogério Padilha , Gomes Anna Raquel Silveira , Santos Flavia Pinotti dos , Coelho Rodrigo Augusto , Valderramas Silvia 
Published: June 2022

Objetivo: Avaliar o desempenho funcional e o histórico de quedas de idosas. Método: Estudo observacional de corte transversal, onde foram selecionadas 57 idosas da comunidade, divididas em 3 grupos, segundo a faixa etária: G1- 60 a 69 anos; G2- 70 a 79 anos e G3- 80 a 89 anos. Foram avaliados: mobilidade funcional ("Timed Up & Go Test"); potência muscular (Teste de sentar e levantar 5 vezes); força de preensão manual (dinamômetro manual JAMAR®), histórico e prevalência de quedas. A análise das diferenças intergrupos foi realizada por meio da ANOVA One way e post hoc Tukey. As correlações foram avaliadas por meio do teste de Spearman. Resultados: Idosas do G3 quando comparadas aos grupos G1 e G2, apresentaram diminuição da FPM (18,08 ± 3,29 Kgf vs. 28,10 ± 4,26 Kgf; 18,08 ± 3,29Kgf vs. 22,92 ± 4,01, p = 0,001), da potencia muscular (14,44 ± 2,85s vs. 12,27 ± 2,34s; 14,44 ± 2,85s vs. 13,16 ± 2,27s, p = 0,04) e da mobilidade funcional (11,56 ± 3,10s vs. 8,57 ± 2,25s; 11,56 ± 3,10s vs. 10,30 ± 2,58s, p = 0,004). A maior prevalência de quedas foi nas idosas do G2 (52,6%) sendo que, nos últimos 6 meses, 26% caíram 1 vez, 5% caíram 2 vezes; 10% caíram 3 e 4 vezes. As idosas do G1 e G3 caíram 1 vez. A frequência de quedas apresentou correlação com mobilidade funcional (r = -0,52, p = 0,018). A idade apresentou correlação com a força de preensão manual (r = -0,67, p = 0,0001), potencia muscular (r = 0,31, p = 0,02) e com mobilidade funcional (r = 0,49, p = 0,0001). Conclusão: A prevalência de quedas foi maior na faixa etária entre 70-79 anos e quanto maior a idade pior o desempenho musculoesquelético e funcional.
Desempenho isocinético dos músculos do joelho de atletas de futsal durante a pré-temporada e o meio de temporada
Authors: Stedile Augusto Rech , Pasqualotto Lidiane Aparecida , Tadiello Gerson Saciloto , Finger André Luis Temp , Marchi Thiago de , Bonetti Leandro Viçosa 
Published: June 2022

O futsal é um esporte de múltiplos sprints, com constantes mudanças de direção, de velocidade e chutes. Além disso, as demandas impostas aos atletas durante uma temporada regular podem resultar em desequilíbrios musculares entre os membros e entre os músculos extensores e flexores do joelho, consequentemente, diminuindo a performance muscular e aumentando o risco de lesões nos atletas. Objetivo: Analisar as diferenças bilaterais; e o impacto de uma temporada regular na força dos músculos do joelho e as relações entre os músculos extensores e flexores. Método: As informações provenientes de um banco de dados sobre as avaliações de pré-temporada e meio de temporada de 15 atletas profissionais de futsal do sexo masculino foram analisadas. O dinamômetro isocinético foi utilizado no modo concêntrico-concêntrico para avaliar os músculos extensores e flexores do joelho nas velocidades angulares de 60º/s, 120º/s, 180º/s e 240º/s.Resultados: Não foram encontradas diferenças significativas nos valores de pico de torque (PT) dos extensores e flexores do joelho e na razão flexores/extensores na comparação entre os membros quando comparados na mesma avaliação e velocidade angular. Entretanto, os valores de PT da avaliação do meio de temporada mostraram-se, em sua maioria, significativamente maiores quando comparados às avaliações de pré-temporada. Conclusão: Estes achados indicam que o treinamento prescrito durante a temporada foram adequados, permitindo aos atletas o aumento da força muscular e evitando desequilíbrios musculares.
Indoleamine 2,3-Dioxygenase 1 Deletion–Mediated Kynurenine Insufficiency in Vascular Smooth Muscle Cells Exacerbates Arterial Calcification
Authors: Ouyang Liu , Yu Changjiang , Xie Zhiyong , Su Xiaoyan , Xu Zengmei , Song Ping , Li Jian , Huang Hui , Ding Ye , Zou Ming-Hui 
Published: June 2022

Background:
IDO1 (indoleamine 2,3-dioxygenase 1) is the rate-limiting enzyme for tryptophan metabolism. IDO1 malfunction is involved in the pathogenesis of atherosclerosis. Vascular smooth muscle cells (VSMCs) with an osteogenic phenotype promote calcification and features of plaque instability. However, it remains unclear whether aberrant IDO1-regulated tryptophan metabolism causes VSMCs osteogenic reprogramming and calcification.

Methods:

We generated global
Apoe
(
apolipoprotein E
) and
Ido1
double knockout mice, and
Apoe
knockout mice with specific deletion of IDO1 in VSMCs or macrophages. Arterial intimal calcification was evaluated by a Western diet–induced atherosclerotic calcification model.

Results:

Global deficiency of IDO1 boosted calcific lesion formation without sex bias in vivo. Conditional IDO1 loss of function in VSMCs rather than macrophages promoted calcific lesion development and the abundance of RUNX2 (runt-related transcription factor 2). In contrast, administration of kynurenine via intraperitoneal injection markedly delayed the progression of intimal calcification in parallel with decreased RUNX2 expression in both
Apoe
−/−
and
Apoe
−/−
Ido1
−/−
mice. We found that IDO1 deletion restrained RUNX2 from proteasomal degradation, which resulted in enhanced osteogenic reprogramming of VSMCs. Kynurenine administration downregulated RUNX2 in an aryl hydrocarbon receptor–dependent manner. Kynurenine acted as the endogenous ligand of aryl hydrocarbon receptor, controlled resultant interactions between cullin 4B and aryl hydrocarbon receptor to form an E3 ubiquitin ligase that bound with RUNX2, and subsequently promoted ubiquitin-mediated instability of RUNX2 in VSMCs. Serum samples from patients with coronary artery calcification had impaired IDO1 activity and decreased kynurenine catabolites compared with those without calcification.

Conclusions:
Kynurenine, an IDO1-mediated tryptophan metabolism main product, promotes RUNX2 ubiquitination and subsequently leads to its proteasomal degradation via an aryl hydrocarbon receptor–dependent nongenomic pathway. Insufficient kynurenine exerts the deleterious role of IDO1 ablation in promoting RUNX2-mediated VSMCs osteogenic reprogramming and calcification in vivo.
Superior electromagnetic interference shielding effectiveness of functionalized MWCNTs filled flexible thermoplastic polymer nanocomposites
Authors: Sit Subhashis , Nath Krishnendu , Das Narayan Chandra , Chakraborty Goutam 
Published: June 2022

Carbon nanotubes (CNTs) impart great multi-functionality when reinforced with a polymer matrix. This paper shows the qualitative and quantitative improvements of the mechanical, electrical, and electromagnetic interference shielding effectiveness properties with the additions of the multiwalled carbon nanotubes (MWCNTs) and functionalized MWCNTs (FMWCNTs) in ethylene methyl acrylate (EMA) polymer. Mechanical characterization is performed through tensile testing, and electromagnetic interference shielding effectiveness (EMI SE) is calculated from the scattering parameters obtained from the vector network analyzer. Both properties improve compared to neat polymer with the reinforcement loadings up to a critical value, from where the properties start to degrade due to the agglomeration of the CNTs. FMWCNTs provide better performance in terms of properties over the MWCNT reinforced nanocomposites. Morphological characterization using a scanning electron microscope justifies a lower percolation threshold of FMWCNT/EMA composite by better electrical conductive network formation. At 10 wt% of FMWCNT loading, the FMWCNT/EMA composite shows 25.1 dB of EMI shielding efficiency combined with excellent mechanical and electrical properties extending its potential use in both industry and academia as an excellent flexible EMI shielding material.