bluuebunny/crossref_metadata_2025_split huggingface dataset:
The utility of low-iodine diet in preparation for thyroid cancer therapy with radioactive iodine—A cohort study
Authors: Luo Hongxiu , Tobey Andrew , Auh Sungyoung , Cochran Craig , Behairy Noha , Merino Maria , Zemskova Marina , Klubo-Gwiezdzinska Joanna 
Published: September 2022

Objective: A low-iodine diet (LID) of &lt;50μ iodine/day is recommended as preparation for radioactive iodine (RAI) therapy in patients with differentiated thyroid cancer (DTC). The 24-h urinary iodine excretion (UIE) is utilized to evaluate the iodine-depleted status. The aim of this study was to test the association between UIE and progression-free survival (PFS).Patients and methods: In total, 70 patients with intermediate- or high-risk DTC, post-total thyroidectomy, adhered to 2 weeks of LID and had UIE measured before RAI therapy. A Cox regression model was performed to study the contribution of UIE to PFS.Results: The study group consisted of 68% (48/70) of women, aged 41.5 [IQR 31.0, 54.0] years, with tumor size 2.8 [IQR 1.8–4.5] cm, and presence of distant metastases in 22.9% (16/70) of patients. Patients were treated with 1–5 RAI dosages with the median cumulative activity of 150 [IQR 102–314] mCi (5.5 [IQR 3.8–11.6] GBq). During the follow-up of 3.7 [IQR 1.5–6.5] years, 21.4% (15/70) of patients had disease progression. The risk of progression was significantly higher in patients with UIE ≥200 µg/day at the time of RAI administration than in those with UIE &lt;200 µg/day (HR 3.35, 95% CI 1.09–10.34, and p = 0.02). However, the multivariate Cox proportional hazards regression analysis adjusted for age, tumor size, and presence of distant metastases suggested that only distant metastases were independently significantly associated with the risk of progression (HR 5.80 (1.17–28.67), p = 0.03).Conclusions: Although UIE ≥200 µg/day might be associated with worse PFS in RAI-treated DTC patients, the presence of distant metastases is a strong independent predictor of progression. Less stringent LID might be sufficient to achieve a UIE of &lt;200 µg/day.
The first case series analysis on efficacy of esmolol injection for in-hospital cardiac arrest patients with refractory shockable rhythms in China
Authors: Lian Rui , Zhang Guochao , Yan Shengtao , Sun Lichao , Gao Wen , Yang Jianping , Li Guonan , Huang Rihong , Wang Xiaojie , Liu Renyang , Cao Guangqing , Wang Yong , Zhang Guoqiang 
Published: September 2022

Background: This study assessed the effects of esmolol injection in patients with in-hospital cardiac arrest (IHCA) with refractory ventricular fibrillation (VF)/pulseless ventricular tachycardia (pVT).Methods: From January 2018 to December 2021, 29 patients with IHCA with refractory shockable rhythm were retrospectively reviewed. Esmolol was administered after advanced cardiovascular life support (ACLS)-directed procedures, and outcomes were assessed.Results: Among the 29 cases, the rates of sustained return of spontaneous circulation (ROSC), 24-h ROSC, and 72-h ROSC were 79%, 62%, and 59%, respectively. Of those patients, 59% ultimately survived to discharge. Four patients with cardiac insufficiency died. The duration from CA to esmolol infusion was significantly shorter for patients in the survival group (SG) than for patients in the dead group (DG) (12 min, IQR: 8.5–19.5 vs. 23.5 min, IQR: 14.4–27 min; p = 0.013). Of those patients, 76% (22 of 29) started esmolol administration after the second dose of amiodarone. No significant difference was observed in the survival rate between this group and groups administered an esmolol bolus simultaneously or before the second dose of amiodarone (43% vs. 64%, p = 0.403). Of those patients, 31% (9 of 29) were administered an esmolol bolus for defibrillation attempts ≤ 5, while the remaining 69% of patients received an esmolol injection after the fifth defibrillation attempt. No significant differences were observed in the rates of ≥ 24-h ROSC (67% vs. 60%, p = 0.73), ≥ 72-h ROSC (67% vs. 55%, p = 0.56), and survival to hospital discharge (67% vs. 55%, p = 0.56) between the groups administered an esmolol bolus for defibrillation attempts ≤ 5 and defibrillation attempts &gt; 5.Conclusion: IHCA patients with refractory shockable rhythms receiving esmolol bolus exhibited a high chance of sustained ROSC and survival to hospital discharge. Patients with end-stage heart failure tended to have attenuated benefits from beta-blockers. Further large-scale, prospective studies are necessary to determine the effects of esmolol in patients with IHCA with refractory shockable rhythms.
Association between ambient PM2.5 and outpatient visits of children's respiratory diseases in a megacity in Central China
Authors: Liu Le , Wang Bingya , Qian Nana , Wei Huiyan , Yang Guangmei , Wan Leping , He Yan 
Published: September 2022

ObjectiveTo explore the relationship between ambient PM2.5 level and outpatient visits of children with respiratory diseases in a megacity, Zhengzhou, in central China.MethodsWe collected daily outpatient visit data, air pollutant data, and meteorological data at the monitoring points of Zhengzhou from the time period 2018 to 2020 and used Spearman's rank correlation to analyze the correlation between children's respiratory outpatient visits and air pollutants and meteorological factors. Generalized additive models were used to analyze the association between PM2.5 exposures and children's respiratory outpatient visits. A stratified analysis was further carried out for the seasons.ResultsFrom 2018 to 2020, the total number of outpatients with children's respiratory diseases was 79,1107, and the annual average concentrations of PM2.5, PM10, SO2, NO2, CO, and O3-8h in Zhengzhou were respectively 59.48 μg/m3, 111.12 μg/m3, 11.10 μg/m3, 47.77 μg/m3, 0.90 mg/m3 and 108.81 μg/m3. The single-pollutant model showed that the risk of outpatient visits for children with respiratory disease increased by 0.341% (95%CI: 0.274–0.407%), 0.532% (95%CI: 0.455–0.609%) and 0.233% (95%CI: 0.177–0.289%) for every 10 μg/m3 increase in PM2.5 with a 3-day lag, 1-day lag, and 1-day lag respectively for the whole year, heating period, and non-heating period. The multi-pollutant model showed that the risk of PM2.5 on children's respiratory disease visits was robust. The excess risk of PM2.5 on children's respiratory disease visits increased by 0.220% (95%CI: 0.147–0.294%) when SO2 was adjusted. However, the PM2.5 effects were stronger during the heating period than during the non-heating period.ConclusionThe short-term exposure to PM2.5 was significantly associated with outpatient visits for children's respiratory diseases. It is therefore necessary to strengthen the control of air pollution so as to protect children's health.
Using wearable devices to generate real-world, individual-level data in rural, low-resource contexts in Burkina Faso, Africa: A case study
Authors: Huhn Sophie , Matzke Ina , Koch Mara , Gunga Hanns-Christian , Maggioni Martina Anna , Sié Ali , Boudo Valentin , Ouedraogo Windpanga Aristide , Compaoré Guillaume , Bunker Aditi , Sauerborn Rainer , Bärnighausen Till , Barteit Sandra 
Published: September 2022

BackgroundWearable devices may generate valuable data for global health research for low- and middle-income countries (LMICs). However, wearable studies in LMICs are scarce. This study aims to investigate the use of consumer-grade wearables to generate individual-level data in vulnerable populations in LMICs, focusing on the acceptability (quality of the devices being accepted or even liked) and feasibility (the state of being workable, realizable, and practical, including aspects of data completeness and plausibility).MethodsWe utilized a mixed-methods approach within the health and demographic surveillance system (HDSS) to conduct a case study in Nouna, Burkina Faso (BF). All HDSS residents older than 6 years were eligible. N = 150 participants were randomly selected from the HDSS database to wear a wristband tracker (Withings Pulse HR) and n = 69 also a thermometer patch (Tucky thermometer) for 3 weeks. Every 4 days, a trained field worker conducted an acceptability questionnaire with participants, which included questions for the field workers as well. Descriptive and qualitative thematic analyses were used to analyze the responses of study participants and field workers.ResultsIn total, n = 148 participants were included (and n = 9 field workers). Participant's acceptability ranged from 94 to 100% throughout the questionnaire. In 95% of the cases (n = 140), participants reported no challenges with the wearable. Most participants were not affected by the wearable in their daily activities (n = 122, 83%) and even enjoyed wearing them (n = 30, 20%). Some were concerned about damage to the wearables (n = 7, 5%). Total data coverage (i.e., the proportion of the whole 3-week study duration covered by data) was 43% for accelerometer (activity), 3% for heart rate, and 4% for body shell temperature. Field workers reported technical issues like faulty synchronization (n = 6, 1%). On average, participants slept 7 h (SD 3.2 h) and walked 8,000 steps per day (SD 5573.6 steps). Acceptability and data completeness were comparable across sex, age, and study arms.ConclusionWearable devices were well-accepted and were able to produce continuous measurements, highlighting the potential for wearables to generate large datasets in LMICs. Challenges constituted data missingness mainly of technical nature. To our knowledge, this is the first study to use consumer-focused wearables to generate objective datasets in rural BF.
Percutaneous endoscopic drainage for acute long segment epidural abscess following endoscopic lumbar discectomy: A case report
Authors: Li Tao , Wu Hui , Yuan Jinghong , Jia Jingyu , Wu Tianlong , Cheng Xigao 
Published: September 2022

IntroductionAcute epidural abscess after percutaneous endoscopic lumbar discectomy is a rare but grievous complication. When faced with a long-segment epidural abscess, open surgery has traditionally been performed which can lead to huge surgical trauma and unpredictable complications. For this reason, surgeons around the world are constantly looking for more minimally invasive and effective surgical methods.Patient ConcernsOur patient was a 32-year-old woman who had been receiving percutaneous endoscopic interlaminar discectomy for L5/S1 lumbar disc herniation one week ago. She returned to our institution with a fever and lower back pain.DiagnosesMagnetic resonance imaging revealed a long segment epidural abscess accompanied by a paravertebral abscess, and staphylococcus aureus was detected in a bacterial culture of pyogenic fluids extracted from the paravertebral abscess.TreatmentsWe performed percutaneous endoscopic drainage (PED) for the epidural abscess. Long-term sensitive antibiotic treatment after surgery.OutcomesImmediate pain relief was achieved and the inflammatory reaction subsided after 4 weeks of antibiotic therapy. Re-examination of the lumbar spine MRI after 1 month showed that the epidural abscess disappeared completely.ConclusionPercutaneous endoscopy allowed us to approach the epidural abscess directly, enabling the immediate drainage of the abscess with minimal trauma to the patient. The good results obtained show that percutaneous endoscopic drainage is a reliable way to treat a long-segment epidural abscess.
Evodiamine and Rutaecarpine as Potential Anticancer Compounds: A Combined Computational Study
Authors: Liu Jingli , Guo Hui , Zhou Jing , Wang Yuwei , Yan Hao , Jin Ruyi , Tang Yuping 
Published: September 2022

Evodiamine (EVO) and rutaecarpine (RUT) are the main active compounds of the traditional Chinese medicinal herb Evodia rutaecarpa. Here, we fully optimized the molecular geometries of EVO and RUT at the B3LYP/6-311++G (d, p) level of density functional theory. The natural population analysis (NPA) charges, frontier molecular orbitals, molecular electrostatic potentials, and the chemical reactivity descriptors for EVO and RUT were also investigated. Furthermore, molecular docking, molecular dynamics simulations, and the analysis of the binding free energies of EVO and RUT were carried out against the anticancer target topoisomerase 1 (TOP1) to clarify their anticancer mechanisms. The docking results indicated that they could inhibit TOP1 by intercalating into the cleaved DNA-binding site to form a TOP1–DNA–ligand ternary complex, suggesting that they may be potential TOP1 inhibitors. Molecular dynamics (MD) simulations evaluated the binding stability of the TOP1–DNA–ligand ternary complex. The calculation of binding free energy showed that the binding ability of EVO with TOP1 was stronger than that of RUT. These results elucidated the structure–activity relationship and the antitumor mechanism of EVO and RUT at the molecular level. It is suggested that EVO and RUT may be potential compounds for the development of new anticancer drugs.
Jak „widzą” niewidomi?
Authors: Chmielecki Konrad 
Published: September 2022

Artykuł porusza problematykę nowej widzialności i reprodukcji pola społecznego „widzenia” u osób niewidomych jako „podmiotów wizualnych” w perspektywie studiów kultury wizualnej. Przyjmując założenie, że kultura wizualna pociąga za sobą rozważania na temat ślepoty, niewidzialnego, niewidomego w perspektywie społecznej, autor śledzi, w jaki sposób niewidomi funkcjonują jako podmioty wizualne w społeczeństwie wizualnym, czyli osoby konstytuujące aktywny społecznie środek wzroku (niezależnie od jego biologicznej zdolności widzenia) oraz jako efekt szeregu kategorii podmiotów wzrokowych. W tym kontekście Nicholas Mirzoeff odwołuje się do przykładu niewidomych, którzy na początku ery panoptycznej stali się przedmiotem społecznej troski państwa, co doprowadziło do powstania instytucji państwowych dla niewidomych. Panoptyzm stworzył niewidomych jako „naturalny” cel społeczeństwa, państwa i troski, właśnie dlatego, że „widzenie” i „bycie widzianym” stały się problematyczne w trosce dyscyplinarnego państwa narodowego. W eseju The Question of Cultural Identity Stuart Hall wyróżnia trzy typy podmiotów: oświeceniowy, socjologiczny i postmodernistyczny. Odniesienie do racjonalnego podmiotu dotyczy także osób niewidomych. Mitchell wspomina Optykę René Descartesa, w której filozof uważał wzrok za „rozszerzoną formę dotyku”, porównując go do „kija używanego przez niewidomych” do wzmocnienia ścieżki w realnej przestrzeni. Podobnie w perspektywie podmiotu ponowoczesnego warto przywołać model „widzenia bez patrzenia” Paula Virilia – reprodukcji intensywnej ślepoty, która jest ostatnią formą „industrializacji ślepoty” przez „maszyny widzenia”. Koncepcja podmiotu fraktalnego Jeana Baudrillarda dowodzi, że życie niewidomych jest „społeczną konstrukcją widzenia”. Podmiot wizualny, który znajdujemy w koncepcji bioobrazów W.J.T. Mitchell, prowadzi nas do wniosku, że obrazy można tworzyć tak, jak obrazy przedmiotu, wyczuwając je w wyobraźni. Nicholas Mirzoeff proponuje wprowadzenie terminu „zdarzenie wizualne” zamiast pojęcia „podmiot wizualny”; jest on generowany w interfejsie z technologią wizualną w procesie komunikacji za pośrednictwem komputera, w którym mogą uczestniczyć również osoby niewidome. Wreszcie, The Passing Billa Violi zostało zinterpretowane w kontekście obrazów wewnętrznych. Trudno nie przywołać tej koncepcji, mówiąc o obrazach, które są efektem „widzenia” niewidomych. Obrazy generowane przez „oko umysłu” pochodzą ze snów, wspomnień, obrazów i wyobrażeń, w których widzimy siebie, ale z punktu widzenia obserwatora – osoby niewidomej. Viola przypisuje tę funkcję wewnętrznych obrazów kamerze wideo, która działa jak świadomość, stając się odzwierciedleniem naszego „ja”. Według Violi można opisać dynamikę świadomości, która na jednym końcu umieszcza obrazy zewnętrzne (także postrzegane przez niewidomych) i obrazy wewnętrzne (stany uczuć, emocje, marzenia senne i społeczne skutki „widzenia”).
Wzorzec dziennikarza według przekazu tygodnika katolickiego „Niedziela”
Authors: Maciaszek Paweł 
Published: September 2022

W tekście przybliżono wzorzec dziennikarza przedstawiony na łamach tygodnika katolickiego „Niedziela”. Celem prezentacji jest znalezienie odpowiedzi na pytania: W jaki sposób powinien wykonywać on swoją pracę? Czy znajdują się objaśnienia, dzięki którym może dokładniej rozumieć dziennikarskie zadania i właściwie je realizować? Objaśnienia te autor odnalazł w tygodniku „Niedziela”; w znajdujących się tam tekstach opisane są następujące zagadnienia związane z dziennikarstwem: misja, profesjonalizm, rzetelność, otwartość, twórczość, uczciwość, etyczność, odpowiedzialność moralna, wyrażanie miłości do Boga – Prawdy, wartości chrześcijańskie. Do realizacji wskazanego celu posłużyły także znajdujące się w „Niedzieli” teksty opisujące błędne pojmowanie pracy dziennikarskiej i tworzenie złego medialnego przekazu. Dziennikarz nierozumiejący dziennikarskiej służby i odrzucający wartości odznacza się brakiem profesjonalizmu, promuje „gwiazdorski styl dziennikarstwa”, zastępuje służbę komercjalnością, posługuje się fałszywymi informacjami, zaprzestaje dążenia do prawdy i wydobywania dobra.
W opracowaniu wykorzystane zostały metody: opisowa i hermeneutyczna; pozwoliły one na przedstawienie podjętego zagadnienia w świetle zgromadzonych publikacji oraz zinterpretowanie przywoływanych z nich treści. W ten sposób odnaleziono odpowiedzi na pytanie o wzorzec dziennikarza.
FAKTOR-FAKTOR YANG MEMPENGARUHI MINAT NASABAH MENABUNG DI BANK SUMSEL BABEL KCP TANJUNG SAKTI
Authors: Munandar Jepri Aris , Onsardi Onsardi 
Published: September 2022

This study aimed to determine affectin factors customersâ€™ saving interest at Sumsel Babel Kcp Tanjung Sakti Bank. The data collection techniques of this study were observation, and questionnaire. The object of this study were customers of Sumsel Babel Kcp Tanjung Sakti Bank in 2019 with a total of 2855. The sample of this study was a non-probability sampling technique with purposive sampling with more than 100 customers. This study used the Slovin formula in sampling with an error rate of 10% and the sample in this study amounted to 97 people. This study used several data analysis techniques, namely instrument test, classical assumption test, respondent response analysis, classical assumption test, multiple linear regression analysis, determinant coefficient, and hypothesis testing. The results of the tests that have been carried out can be concluded that Knowledge (X_1), Products (X_2) and Promotion (X3) on the dependent variable savings interest (Y). It can be seen in the F test which states the value of F_count> Ftable, namely (163.654> 2.702 ) and (sig Î± = 0.000 <0.050), in other word that H_3 is accepted, meaning that simultaneously Knowledge (X_1), Product (X_2) and Promotion (X3) variables have a significant effect toward customersâ€™ saving interest (Y) at Bank Sumsel Babel KCP Tanjung Sakti.Â Keywords: Products, Promotion, and Interest in Saving
PENGARUH PELATIHAN TERHADAP KINERJA KARYAWAN DENGAN MOTIVASI SEBAGAI VARIABEL INTERVENING PADA USAHA KONVEKSI ADIGUNA KOTA BENGKULU
Authors: Saefulloh Azis , Ekowati Sri 
Published: September 2022

This study aimed to find outthe effect of training on employee performance with motivation as an Intervening variable in the Adiguna Convection Business at Bengkulu City. There were several factors that would be discussed in this study, including training and motivation as Intervening variables. The object in this study were 40 employees at the Adiguna Convection Business in Bengkulu City. In this study, the researcher employed data collection methods through conducting observation, interviews and distributing questionnaires. There were several data analysis techniques employed in this study, including using instrument tests, classical assumption tests, analysis of respondent responses, simple linear regression analysis, determinant coefficient, and hypothesis testing. From the results of the tests that have been carried out, it can be concluded that the Training variable (X) has a positive and significant effect on Employee Performance (Y) at the Adiguna Convection Business in Bengkulu City.Then, the motivation variable (Z) mediates training positively and significantly on employee performance (Y) at the Adiguna Convection Business in Bengkulu City. Moreover, from the results of the simple linear regression test, the regression equation is gained as follows: The first equation, Z = 3.530 + 1.053 (X). The second equation Y = 0.749 + 1.095 (X). Third equation Y = 2.067 + 1.027 (Z)Â Keywords: Training, Motivation And Employee Performance
PENGARUH MARKETING ONLINE DAN E-SERVICE QUALITY TERHADAP KEPUTUSAN PEMBELIAN (Studi Kasus Pembelian Produk Labbaik Chicken)
Authors: Setiadi Yulius Wahyu 
Published: September 2022

This study aims to determine the effect of Online Marketing and E-Service Quality on purchasing decisions, either partially or simultaneously. The independent variables in this study are online marketing (X1), e-service quality (X2), and the dependent variable, namely purchasing decisions (Y). In this research, the writer uses the method of collecting data by means of observation, distributing questionnaires or questionnaires. And the research location is in Labbaik Chicken, Bengkulu city. The population and sample of this research are all consumers who buy fast food products at Labbaik Chicken, and the determination of the sample in this study uses purposive sampling technique, with the criteria namely (1) Respondents who have bought food or beverage products from Labbaik Chicken Bengkulu City, (2) ) Respondents who have updated information about fast food products on their social networks, (3) Respondents who come directly to fast food restaurants. Since the population in this study is unknown, the authors use the MSI method (method of successive interval) by transforming the ordinal scale data into interval scale data, with 5-10 samples for indicators in all variables used, namely 12 indicators with The minimum sample results are 60 respondents and the maximum sample is 120 respondents, in this study the number of samples used is 120 respondents who are considered to have met the requirements. The data analysis techniques in this study the authors used several data analysis techniques, namely instrument test, classical assumption test, multiple linear regression analysis, determinant coefficient, and hypothesis testing. From the results of the tests that have been done, it can be concluded that Online Marketing (), and E-Service Quality () on the dependent variable of Purchase Decision (Y) have a significant effect, this can be seen in the F test which states the value>, namely (99.579> 3.074 ) and (sig = 0.000 <0.050), thus it can be concluded that it is accepted that the online Marketing () and E-Service Quality () variables simultaneously have a significant influence on Purchasing Decisions (Y), in Labbaik Chicken, Bengkulu City.Â Keywords:Â Online Marketing, E-Service Quality Purchasing Decisions