bluuebunny/crossref_metadata_2025_split huggingface dataset:
Gottfried Benn´s “brains” novella from 1916: implications for the philosophy of mind
Authors: Wolf Gunter 
Published: February 2025

Abstract
Gottfried Benn (1886–1956) was a major 20th-century German physician-poet and essayist. He successfully completed his medical studies and worked across several hospitals and disciplines, including pathology, performing many autopsies. Later in life, Benn ran his own practice to treat skin and venereal diseases in Berlin for many years. Benn is not well-known in English-speaking countries and only a few of his poems have been translated into English so far. One possible reason for this may have been his initial enthusiasm for National Socialism (as documented in essays, see below), which led to a break with other authors of his generation who had to emigrate. His novella collection "Gehirne" (Brains), published in 1918, was a significant contribution to expressionist short prose. In this work, Dr. Rönne (Benn's alter ego) searches in vain for the soul and personality in the brain matter. This leads to increasing psychological instability and depression, and Rönne can no longer carry out his medical work. The purpose of this article is to familiarize the interested reader with Benn's biography and to analyze the novella in more detail, especially in terms of the concepts of the mind’s philosophy.
Illness cognition, illness perception and related factors in patients with lymphangioleiomyomatosis
Authors: Huang Liting , Yang Lulu , Ouyang Ruoyun , Ren Siying 
Published: February 2025

Abstract

Purpose
To explore the self-perceived illness cognition and perception status, as well as the relevant factors among lymphangioleiomyomatosis (LAM) patients.

Methods
A web-based questionnaire survey was conducted in September 2023. A total of 121 LAM patients participated (including 16 patients with TSC-LAM), and the survey collected general demographic information, responses to a disease cognition questionnaire, and a simplified disease perception questionnaire.

Results
LAM patients have a higher level of negative illness cognition and a lower level of positive illness cognition, specifically characterized by helplessness (15.74 ± 4.68 points), acceptance (16.00 ± 3.28 points), and perceived benefits (16.92 ± 3.86 points). Single-factor analysis of variance found significant correlations between cultural level, age, family average monthly income, use of rapamycin, use of home oxygen therapy, hospitalization frequency, disease duration, severity of respiratory distress, activity limitation, and the helplessness score of LAM patients (p ≤ 0.05); the number of children was significantly associated with acceptance scores of LAM patients (p ≤ 0.05); and whether surgery had been performed was significantly associated with acceptance and perceived benefits scores of LAM patients (p ≤ 0.05). Disease duration and activity limitation entered the regression equation for helplessness dimension, while whether surgery had been performed entered the regression equation for perceived benefits dimension, but no factor entered the regression equation for acceptance dimension. Applying the same analysis to disease perception, we found that the average score of the Illness Perception Questionnaire was 45.43 ± 8.97, with lower scores in the reverse-scored items of individual control, treatment, and understanding.

Conclusions
LAM patients exhibit higher levels of helplessness, particularly among those with longer disease duration and greater activity limitations, leading to a more negative perception of the disease. Additionally, patients who have undergone surgical procedures tend to perceive fewer benefits. Furthermore, there is a significant correlation between illness perception and factors such as rapamycin usage, home oxygen therapy, disease duration and activity limitations caused by LAM. This indicates that clinical healthcare providers should pay more attention to LAM patients and their associated groups, providing both informational and psychological support.
Radiofrequency ablation for peribiliary hepatocellular carcinoma: propensity score matching analysis
Authors: Cui Jin , Sui Xinzi , Liu Kaiwen , Huang Min , Zheng Yuanwen , Zhao Xinya , Wang Gongzheng , Wang Ximing 
Published: February 2025

Abstract

Objectives
At present, there are no established clinical guidelines for radiofrequency ablation (RFA) of peribiliary hepatocellular carcinoma (HCC). Therefore, the aim of this study was to compare the long-term outcomes of RFA for peribiliary vs. non-peribiliary HCC.

Methods
This retrospective study included 282 patients with peribiliary HCC (n = 109) or non-peribiliary HCC (n = 173) who received RFA between February 2013 and May 2021. Local tumor progression (LTP), overall survival (OS), disease-free survival (DFS), and complications were compared before and after propensity score matching (PSM).

Results
Before PSM, there were no significant differences in 5-year LTP rates (26.3% vs. 23.6%, p = 0.602), OS rates (56.6% vs. 68.0%, p = 0.586), or DFS rates (22.9% vs. 25.7%, p = 0.239) between the peribiliary and non-peribiliary groups. After PSM, there were no significant differences in the 1-, 3-, and 5-year LTP rates (13.0%, 23.1%, and 26.3% vs. 12.1%, 25.1%, and 28.2%, respectively, p = 0.857), OS rates (97.2%, 73.5%, and 56.6% vs. 95.3%, 79.5%, and 70.6%, p = 0.727), or DFS rates (59.4%, 29.4%, and 22.9% vs. 64.2%, 33.1%, and 23.8%, p = 0.568) between the peribiliary non-peribiliary groups. Peribiliary location was not a significant prognostic factor for LTP (p = 0.622) or OS (p = 0.587). In addition, mild intrahepatic bile duct dilatation was more frequent in the peribiliary group (9.2% vs. 2.8%, p = 0.045).

Conclusion
Long-term outcomes of RFA were similar for peribiliary and non-peribiliary HCC. RFA is a viable alternative for treatment of peribiliary HCC.

Critical relevance statement
The local tumor progression (LTP), overall survival (OS), and disease-free survival (DFS) rates after radiofrequency ablation (RFA) were similar for peribiliary and non-peribiliary hepatocellular carcinoma (HCC).

Key Points

There are currently no clinical guidelines for radiofrequency ablation (RFA) of peribiliary hepatocellular carcinoma (HCC).

Local tumor progression, overall survival, and disease-free survival after RFA were similar for peribiliary and non-peribiliary HCC.

RFA is a viable alternative for the treatment of peribiliary HCC.

Graphical Abstract
Tidal correlation of deep tectonic tremors increases during long-term slow slip events in the Bungo Channel, southwest Japan
Authors: Hirose Fuyuki , Kobayashi Akio 
Published: February 2025

Abstract
In the Bungo Channel along the Nankai Trough, southwest Japan, long-term slow slip events (LSSEs) of about

$${M}_{\text{w}}$$

M
w

6–7 and lasting 6–12 months occur at several-year intervals at the base of the seismogenic zone. In sync with these LSSEs, deep tectonic tremors are activated at the base of the LSSE zone. The tidal response of tectonic tremors during short-term slow slip events lasting several days has been extensively investigated, but variations of the tidal correlation of tectonic tremors over periods on the order of years remain poorly understood. Here, we investigated long-term temporal changes in the correlation between deep tectonic tremors and tides in the Bungo Channel. We found that tectonic tremors along the base of the LSSE region (region Ba) are strongly correlated with tidal shear stress and/or Coulomb failure stress under a very small apparent friction coefficient, and that these tremors are more likely to occur when the tidal stress acting in the direction promoting fault slip is large. We also found that tidal sensitivity is relatively high during LSSE periods and low during other periods. Because the LSSE region largely includes region Ba, fault coupling in region Ba during LSSE periods is undoubtedly smaller than during other periods. As a result of this low friction state, even tidal stresses much smaller than the lithostatic stress can affect the generation of deep tectonic tremor, and tidal sensitivity during LSSE periods seems to be higher than during other periods.

Graphical abstract
BOLD and DW- MRI metrics in predicting bladder urothelial carcinoma histologic grade and muscle invasion: a prospective study
Authors: Ezz Eldin Omnia , Nouh Mohamed Ragab , Refaai Khaled , Abdou Marwa Shawky , Gouda Heba Refaat , Altarawy Dina , Samir Ahmed 
Published: February 2025

Abstract

Background
The preoperative evaluation of bladder cancer (BC) pathological grade and muscle invasion is crucial for effective management outcomes. MRI is noninvasive and has no radiation exposure. MRI sequences enable anatomical and functional assessment with the capability of using functional quantitative parameters as biomarkers to analyze tissue characteristics. This study aimed to investigate the utility of apparent diffusion coefficient (ADC) and apparent transverse relaxation rate (R2*) in predicting preoperative histopathological grade and detrusor muscle invasion in bladder cancer (BC).

Results
This ethically approved prospective clinical study included 53 patients with suspected bladder tumors (mean age 62.85 years ± 10.02 [SD]; 49 males). Two independent readers had strong concordance in measuring ADC and R2* values (ICC > 0.9), with significantly negative correlation observed between R2* and ADC (p < 0.001). ADC cutoff value of (0.79 × 10–3 mm2/s) predicted high-grade and muscle invasive bladder cancers with diagnostic accuracies of (90.57%) and (84.9%); respectively. R2* cutoff values of (17.8/s) and (18.1/s) predicted high-grade and muscle invasive bladder cancers with diagnostic accuracies of (88.68%) and (83.02%); respectively. The conjugate R2* and ADC exhibited high diagnostic accuracies that were more impressive for predicting the histologic grade (94.2%) than for muscle invasiveness (82.7%).

Conclusions
ADC and R2* deployment for preoperative bladder cancer evaluation has excellent potential to predict tumor grades and detrusor muscle invasion, aiding in management planning.
Translational lessons from the balanced immune system in bats
Authors: Ng Wei Lun , Wang Lin-Fa 
Published: February 2025

ABSTRACT
Bats are a natural reservoir for a wide variety of notorious viruses that are deadly to humans and other mammals but cause no or minimal clinical damage in bats. The co-evolution of bats and viruses for more than sixty million years has established unique and balanced immune defenses within bats against a number of viruses. With the COVID-19 pandemic, bats have gained greater attention as a likely reservoir of the SARS-CoV-2 ancestor virus. The coupling of omics technology and bat research opens an exciting new field to understand and translate discoveries from bats to humans, in the context of infectious disease and beyond. Here, we focus on the mechanism of immunity balance in bats, the application of omics and how this might lead to improvement of human health.
Partition and Prosper: Design and Pricing of Single Bundle
Authors: Sun Hailong , Li Xiaobo , Teo Chung-Piaw 
Published: February 2025

Design and Pricing of a Single Bundle Product bundling is a widely used selling strategy among multiproduct firms, yet designing and pricing bundles optimally remain a complex challenge. In “Partition and Prosper: Design and Pricing of a Single Bundle,” Sun, Li, and Teo show that the selection and pricing of a single bundle from a range of products under multivariate normal valuations is polynomial-time solvable, provided that the associated covariance matrix can be decomposed into a positive diagonal matrix minus a positive semidefinite matrix of (small) fixed rank. Interestingly, they also show that if the individual product prices are predetermined, the optimization problem becomes NP hard even if customer valuations are independent. The authors use a Bayesian optimization algorithm combined with a novel conic integer programming reformulation to solve the problem under general valuation distributions and demonstrate the superior numerical performance of the algorithm via extensive simulations.
Emotion regulation and compassion fatigue in mental health professionals in a context of stress: A longitudinal study
Authors: Brillon P. , Dewar M. , Lapointe V. , Paradis A. , Philippe F. L. 
Published: February 2025

Introduction
Mental health professionals (MHP) are exposed to several stressors and have emotionally demanding jobs. They must effectively manage their emotions within their everyday practice. Emotion regulation is therefore a key element in understanding how MHPs can protect themselves psychologically. Abundant research shows that healthy and effective emotion regulation can protect against the negative impact of stress on compassion fatigue. However, this perspective does not consider the dynamic interaction that emotion regulation and compassion fatigue can have over time. A much less researched perspective is how compassion fatigue can change emotion regulation styles over time. The present research focused on this dynamic perspective.

Objective
We took advantage of the COVID-19 pandemic, a stressful period for MHPs, to study the effect of perceived stress on the direction of the changes in emotion regulation styles and compassion fatigue over time.

Methods
Data on stressors, perceived stress, emotion regulation styles (i.e., dysregulation, integration, and suppression), and compassion fatigue were collected from 390 MHPs at two time points over ten months.

Results
Findings from a cross-lagged path analysis suggests that perceived stress predicted increases in dysregulation over time. Moreover, there were bidirectional longitudinal associations between dysregulation and compassion fatigue, with each predicting increases in compassion fatigue and dysregulation over time, respectively.

Conclusions
This study contributes to the limited research on the factors that influence how MHPs regulate their emotions and their susceptibility to compassion fatigue. Implications of emotion regulation for MHPs’ own mental health and ability to do their work effectively are discussed.
Evaluating Covid-19 publications for sex and gender-specific health content: A bibliometric analysis
Authors: Oyasu Abigail , Salter-Volz Aysha , Yeh Chen , Muhammad Lutfiyya N. , Jagsi Reshma , Woitowich Nicole C. 
Published: February 2025

Background
Sex and gender are key variables which inform human health and disease. It remained unclear how sex and gender were considered, evaluated, reported, or analyzed within Covid-19 research. This article evaluates the proportion of Covid-19-related articles which highlighted sex- or gender-specific health content and examines associations with author gender.

Materials and methods
Article records for 134,008 publications indexed in the LitCovid database were extracted on June 1st, 2021. Metadata such as publication year, author names, and country of institutional affiliation were obtained from Elsevier’s SCOPUS database by matching PubMed Identifiers (PMIDs). Only articles with matching SCOPUS records were included in the study, resulting in a final sample of 94,488 articles. First and last author gender was assigned to a subset of 71,597 articles. Article title, abstracts, and keywords were screened for sex or gender-specific health content using a text-based search strategy. Descriptive statistics and regression analyses were used to study associations between author gender and the presence or absence of sex or gender-related health content.

Results
Only 4% of Covid-19-related articles highlighted sex or gender-related health content. Papers with women first authors were more likely to highlight sex or gender-related health content compared to papers with men as first authors (4.15% n = 1,339 vs 3.68%, n = 1,997) [X2 (1, n = 86,468) = 12,01, p = 0.0005]. Papers with women first and last authors had an increased probability of addressing sex or gender-related health with an odds ratio of 1.16 (95% CI 1.04 – 1.29). While there was no association between author gender and journal impact, articles which highlighted sex or gender-related health content were published in journals with higher CiteScores [Mdn = 5.0, Q1-Q3 (3.5–8.2) vs. Mdn = 4.7, Q1-Q3 (2.8–8.0)].

Conclusions
The paucity of publications to highlight sex or gender in the context of the Covid-19 pandemic is alarming. Research that focuses on the influence of sex and or gender is essential for advancing the scientific understanding of disease processes.
Evaluation of the variations of mandibular molars and the distance from root apex to the inferior alveolar nerve in Saudi Sub-population: Three-dimensional radiographic evaluation
Authors: Aqili Tariq Mohammed , Almuzaini Esam Sami , Aljohani Abdulbari Saleh , Saeedi Ahmed Khaled Al , Hammudah Hassan Abdulmuti , Alassaf Muath , Hakeem Muhannad M. 
Published: February 2025

Aim
To investigate the prevalence of various morphological variations in the roots and canals of lower mandibular molar teeth in the Saudi subpopulation and measure the distance from the root apices to the inferior alveolar canal (IAC).

Materials and methods
A cross-sectional analysis was conducted on 149 CBCT scans from Taibah University the College of Dentistry (TUCD). Three evaluators independently reviewed scans for anatomical features such as the number of canals, the presence of radix molaris (RM), and root-to-IANC distances. Teeth observed from the medullary cavity to the root apical layers on the coronal, sagittal and cross-section views. Data was analyzed using SPSS 21.0 software. Statistically significant differences were defined at p < 0.05.

Results
The prevalence of RM ranged between 0.7%-3.4% in lower first and second molars. The number of the canals in the apex ranged between 2–4 canals, with most molars showing three canals. The prevalence of 2 canals in lower first molars is around 2% and in lower second molars is 9.2%. A significant age-related correlation was noted in distances from the mesial and distal roots to the IAC, with values ranging from 0 to 14.7 mm.

Conclusion
The study reveals diverse root and canal morphologies and varying distances to the IANC within the Saudi subpopulation, emphasizing the necessity for precise preoperative radiographic assessments to optimize endodontic outcomes and reduce procedural risks. Findings suggest the need for further research into these anatomical variations to refine diagnostic and treatment strategies in endodontics, particularly in diverse populations to improve patient outcomes.
Mapping women’s work in India: An application of small area estimation
Authors: Srivastava Swati , Kumar Kaushalendra , McDougal Lotus , Upadhyay Ashish Kumar , Hay Katherine , Singh Abhishek 
Published: February 2025

Background
Understanding variations in women’s work participation at lower administrative levels, such as districts, is a missing link in identifying trends, patterns and variation that can offer insights into this long-term stagnation. We link data from the 2019–21 Indian National Family Health Survey and the 2011 Indian Population and Housing Census to generate estimates of women’s work within 640 districts of India, and to examine the spatial clustering of women’s work across these districts. We examine women’s work through three outcome variables, namely, district-level estimates of 1) percentage of women who worked in the past 12 months, 2) percentage of women who were self-employed in the past 12 months, and 3) percentage of women who earned cash in the past 12 months.

Results
Diagnostic measures confirm that our model-based estimates are robust enough to provide reliable district-level estimates of women’s work in India. Women’s work and cash earnings were lowest in the districts of the central, eastern, and northern regions, and highest in the southern region. Self-employment rates for women were generally low in Indian districts, except for districts in Himachal Pradesh and the north-eastern region.

Conclusions
Considerable spatial heterogeneity in women’s work has been found across 640 districts of India. Our study demonstrates that estimated percentage of women who worked in the past 12 months, estimated percentage of women who earned cash in the past 12 months and estimated percentage of women who were self-employed in the past 12 months all vary substantially at the district level. Having only state-level estimates may thus be inadequate to inform efforts to remediate low levels of women’s work in India. The insights from our current study may help in the formulation and implementation of targeted policies that increase opportunities for women to expand their paid work in India.
Optimal fiber mix and prediction model for compressive strength of hybrid fiber reinforced concrete
Authors: Gao Ping , Xie Weihong , Ling Yongqiang , Xu Hongfa 
Published: February 2025

Incorporating single or mixed types of fibers into concrete is an effective method for enhancing its performance. This study aimed to investigate the optimal fiber mix for hybrid fiber reinforced concrete (HFRC) that includes end-hooked steel fibers (ESF), corrugated steel fibers (CSF), and polypropylene fibers (PF), and to predict its compressive strength. To this end, three combinations of HFRC were designed: ESF and CSF (EC-HFRC), ESF and PF (EP-HFRC), and CSF and PF (CP-HFRC), respectively. Plain concrete and single-fiber reinforced concrete with the same mix proportions were also designed for comparison. The compressive strength test results demonstrate slight to moderate enhancement in the concrete’s compressive strength when hybrid fibers are employed. The hybrid effects observed in both EP-HFRC and CP-HFRC are superior to those of EC-HFRC. The optimal fiber mixing combinations are identified as 0.2% PF combined with 1.5% ESF for EP-HFRC and 0.2% PF along with 1.5% CSF for CP-HFRC. Compared with single steel fiber admixture and no fiber admixture, the mixing of hybrid fibers can significantly impact the failure mode of concrete. A novel mathematical model, based on the theory of composite mechanics, has been proposed to accurately predict the compressive strength of single steel fiber reinforced concrete and EC-HFRC, as evidenced by its close alignment with experimental data. The results of this paper provide substantial theoretical support for the design and optimization of HFRC.
Fundus autofluorescence features specific for EYS-associated retinitis pigmentosa
Authors: Kominami Taro , Tan Tien-En , Ushida Hiroaki , Jain Kanika , Goto Kensuke , Bylstra Yasmin M. , Sajiki Ai Fujita , Mathur Ranjana S. , Ota Junya , Lim Weng Khong , Nishiguchi Koji M , Fenner Beau J. 
Published: February 2025

Purpose
To assess the utility of fundus autofluorescence (FAF) patterns for predicting the EYS genotype in retinitis pigmentosa (RP) patients.

Methods
This retrospective, multi-institutional study analyzed FAF images from 200 RP patients (74 with EYS and 126 without EYS) from Singapore and Japan. Seven FAF patterns including the infinity sign and a broad banded hyper-autofluorescent leading edge were evaluated for their association with the EYS genotype.

Results
The infinity sign and broad banded hyperautofluorescent leading edge occurred more frequently in EYS eyes (p = 0.0014 and p = 0.036 respectively). Logistic regression analysis showed that the infinity sign was predictive of EYS (p = 0.003). The combined FAF parameters predicted EYS with a specificity of 95.20%, sensitivity of 25.68% and accuracy of 69.50%, with a cut-off value 0.5 based on the probability of seven FAF parameters.

Conclusions
In this multinational cohort study of patients with RP, we demonstrated that specific FAF patterns, particularly the infinity sign, have clinical utility in identifying patients with EYS-associated disease. These findings may be useful for clinicians and geneticists when genotyping patients with RP, and may also enhance our understanding of underlying pathophysiology of EYS-associated RP, which is a prevalent cause of RP in Asia and elsewhere.