bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Pristine dwarf galaxy survey – IV. Probing the outskirts of the dwarf galaxy Boötes I
Authors: Longeard Nicolas , Jablonka Pascale , Arentsen Anke , Thomas Guillaume F , Aguado David S , Carlberg Raymond G , Lucchesi Romain , Malhan Khyati , Martin Nicolas , McConnachie Alan W , Navarro Julio F , Sánchez-Janssen Rubén , Sestito Federico , Starkenburg Else , Yuan Zhen 
Published: July 2022

ABSTRACT
We present a new spectroscopic study of the dwarf galaxy Boötes I (Boo I) with data from the Anglo-Australian Telescope and its AAOmega spectrograph together with the Two Degree Field multi-object system. We observed 36 high-probability Boo I stars selected using Gaia Early Data Release 3 proper motions and photometric metallicities from the Pristine survey. Out of those, 27 are found to be Boo I stars, resulting in an excellent success rate of 75 per cent at finding new members. Our analysis uses a new pipeline developed to estimate radial velocities and equivalent widths of the calcium triplet lines from Gaussian and Voigt line profile fits. The metallicities of 16 members are derived, including 3 extremely metal-poor stars ([Fe/H] &lt; −3.0), which translates into a success rate of 25 per cent at finding them with the combination of Pristine and Gaia. Using the large spatial extent of our new members that spans up to 4.1 half-light radii and spectroscopy from the literature, we find a systemic velocity gradient of 0.40 ± 0.10 km s−1 arcmin−1 and a small but resolved metallicity gradient of −0.008 ± 0.003 dex arcmin−1. Finally, we show that Boo I is more elongated than previously thought with an ellipticity of ϵ = 0.68 ± 0.15. Its velocity and metallicity gradients as well as its elongation suggest that Boo I may have been affected by tides, a result supported by direct dynamical modelling.
Implications from secondary emission from neutral impact on Cassini plasma and dust measurements
Authors: Johansson F L , Vigren E , Waite J H , Miller K , Eriksson A I , Edberg N J T , Dreyer J 
Published: July 2022

ABSTRACT
We investigate the role of secondary electron and ion emission from impact of gas molecules on the Cassini Langmuir probe (RPWS-LP or LP) measurements in the ionosphere of Saturn. We add a model of the emission currents, based on laboratory measurements and data from comet 1P/Halley, to the equations used to derive plasma parameters from LP bias voltage sweeps. Reanalysing several hundred sweeps from the Cassini Grand Finale orbits, we find reasonable explanations for three open conundrums from previous LP studies of the Saturn ionosphere. We find an explanation for the observed positive charging of the Cassini spacecraft, the possibly overestimated ionospheric electron temperatures, and the excess ion current reported. For the sweeps analysed in detail, we do not find (indirect or direct) evidence of dust having a significant charge-carrying role in Saturn’s ionosphere. We also produce an estimate of H2O number density from the last six revolutions of Cassini through Saturn’s ionosphere in greater detail than reported by the Ion and Neutral Mass Spectrometer. Our analysis reveals an ionosphere that is highly structured in latitude across all six final revolutions, with mixing ratios varying with two orders of magnitude in latitude and one order of magnitude between revolutions and altitude. The result is generally consistent with an empirical photochemistry model balancing the production of H+ ions with the H+ loss through charge transfer with e.g. H2O, CH4, and CO2, for which water vapour appears as the likeliest dominant source of the signal in terms of yield and concentration.
Advanced asteroseismic modelling: breaking the degeneracy between stellar mass and initial helium abundance
Authors: Verma Kuldeep , Rørsted Jakob L , Serenelli Aldo M , Aguirre Børsen-Koch Víctor , Winther Mark L , Stokholm Amalie 
Published: July 2022

ABSTRACT
Current stellar model predictions of adiabatic oscillation frequencies differ significantly from the corresponding observed frequencies due to the non-adiabatic and poorly understood near-surface layers of stars. However, certain combinations of frequencies – known as frequency ratios – are largely unaffected by the uncertain physical processes as they are mostly sensitive to the stellar core. Furthermore, the seismic signature of helium ionization provides envelope properties while being almost independent of the outermost layers. We have developed an advanced stellar modelling approach in which we complement frequency ratios with parameters of the helium ionization zone while taking into account all possible correlations to put the most stringent constraints on the stellar internal structure. We have tested the method using the Keplerbenchmark star 16 Cyg A and have investigated the potential of the helium glitch parameters to constrain the basic stellar properties in detail. It has been explicitly shown that the initial helium abundance and mixing-length parameters are well constrained within our framework, reducing systematic uncertainties on stellar mass and age arising for instance from the well-known anticorrelation between the mass and initial helium abundance. The modelling of six additional Kepler stars including 16 Cyg B reinforces the above findings and also confirms that our approach is mostly independent of model uncertainties associated with the near-surface layers. Our method is relatively computationally expensive, however, it provides stellar masses, radii and ages precisely in an automated manner, paving the way for analysing numerous stars observed in the future during the ESA PLATO mission.
A Bayesian approach to high-fidelity interferometric calibration – I. Mathematical formalism
Authors: Sims Peter H , Pober Jonathan C , Sievers Jonathan L 
Published: July 2022

ABSTRACT
High-fidelity radio interferometric data calibration that minimizes spurious spectral structure in the calibrated data is essential in astrophysical applications, such as 21 cm cosmology, which rely on knowledge of the relative spectral smoothness of distinct astrophysical emission components to extract the signal of interest. Existing approaches to radio interferometric calibration have been shown to impart spurious spectral structure to the calibrated data if the sky model used to calibrate the data is incomplete. In this paper, we introduce BayesCal: a novel solution to the sky-model incompleteness problem in interferometric calibration, designed to enable high-fidelity data calibration. The BayesCal data model supplements the a priori known component of the forward model of the sky with a statistical model for the missing and uncertain flux contribution to the data, constrained by a prior on the power in the model. We demonstrate how the parameters of this model can be marginalized out analytically, reducing the dimensionality of the parameter space to be sampled from and allowing one to sample directly from the posterior probability distribution of the calibration parameters. Additionally, we show how physically motivated priors derived from theoretical and measurement-based constraints on the spectral smoothness of the instrumental gains can be used to constrain the calibration solutions. In a companion paper, we apply this algorithm to simulated observations with a HERA-like array and demonstrate that it enables up to four orders of magnitude suppression of power in spurious spectral fluctuations relative to standard calibration approaches.
Recent advances in IgG4-related kidney disease
Authors: Kawano Mitsuhiro , Saeki Takako , Ubara Yoshifumi , Matsui Shoko 
Published: July 2022

ABSTRACTRecent advances in the management and understanding of immunoglobulin (Ig)G4-related kidney disease (RKD) have emphasized the importance of urgent treatment in IgG4-related tubulointerstitial nephritis. On the other hand, to avoid long-term glucocorticoid toxicity, strategies for early withdrawal of steroids or combination of immunosuppressants, such as rituximab, and the minimum dose of steroids have been pursued. However, disease recurrence after reducing or stopping steroid therapy hampers early withdrawal of glucocorticoid maintenance therapy. In addition, knowledge has accumulated in diagnostic approaches including differential diagnosis of anti-neutrophil cytoplasmic antibodies-associated vasculitis, idiopathic multicentric Castleman’s disease, and Rosai–Dorfman disease with kidney lesion, which leads to earlier and precise diagnosis of IgG4-RKD. This review summarizes recent progress in the differential diagnosis of IgG4-RKD and related treatment strategies and recent topics of hypocomplementaemia, membranous glomerulonephritis, and IgG4-related pyelitis and periureteral lesion.
Early predictors of colchicine resistance in familial Mediterranean fever
Authors: Mosad Mosa Doaa , Shokry Doaa , Ahmed Dina B , Sobh Ali 
Published: July 2022

ABSTRACT

Objective
To explore early features that can predict colchicine resistance in familial Mediterranean fever (FMF) patients.

Methods
It included FMF cases who fulfilled the Yalcinkaya–Ozen criterion and were on colchicine for at least 6 months. Data were collected from medical files and interpreted with respect to clinical parameters, incluing the auto-inflammatory diseases activity index (AIDAI) and FMF severity score. FMF50 score assessed the treatment response. Laboratory findings and genetic analysis of Mediterranean fever (MEFV) mutations were evaluated according to the standard technique. Patients were classified into two groups according to their response to colchicine. Both groups were compared, and significant variables were entered into a logistic regression model to detect independent predictors. The diagnostic accuracy of these predictors was assessed using the receiver operating characteristic curve.

Results
In all, 120 FMF children were included. After the exclusion of 16 non-compliant patients (13.3%), colchicine responders were 66 (63.4%) (group I) and colchicine-resistant cases (group II) were 38 (36.5%). The fever duration after colchicine, number of attacks before/after colchicine, skin rash/erysipelas-like erythema, myalgia/protracted febrile myalgia, AIDAI before/after treatment, FMF severity score, and the maximum colchicine dose were higher in group II. Furthermore, high C-reactive protein and neutropenia were frequent in group II. However, different MEFV mutations, including M694V were similar between the two groups. Eight variables were detected in the regression analysis model, and independent predictors were utilized to generate a scoring model.

Conclusion
This study constructed a prediction model for colchicine nonresponse based on clinical and laboratory profiles. This model will be valuable for the treatment decisions of FMF children.
The European Kidney Health Alliance (EKHA) and the Decade of the KidneyTM
Authors: Vanholder Raymond , Conway Paul T , Gallego Daniel , Scheres Eveline , Wieringa Fokko 
Published: July 2022

Abstract
The European Kidney Health Alliance (EKHA) is an advocacy organization that defends the case of the kidney patients and the nephrological community at the level of the European Union (EU), and from there, top to bottom, also at the national level of the EU member states and the EU-associated countries. The Decade of the KidneyTM is a global initiative launched by the American Association of Kidney Patients (AAKP) to create greater awareness and organize patient demands for long overdue innovation in kidney care. This article describes the medical and patient burden of kidney disease, the history of EKHA, its major activities and tools for policy action, and the need for innovation of kidney care. We then describe the Decade of the KidneyTM initiative, the rationale behind why EKHA joined this activity to emanate parallel action at the European side, the novel professionalized structure of EKHA, and its immediate targets. The final aim is to align all major stakeholders for an action plan on kidney disease comparable to Europe's successful Beating Cancer Plan, with the additional intent that the EKHA model is applied also by the respective national kidney-related societies to create a broad mobilization at all levels. The ultimate aims are that the EU considers chronic kidney disease (CKD) as a major health and health-economic problem, to consequently have CKD included as a key health research target by the European Commission, and to improve quality of life and outcomes for all kidney patients.
Care maps: De-medicalizing children with medical complexity
Authors: Dharmaraj Blossom G , Adams Sherri , Orkin Julia 
Published: July 2022

Abstract
Children with medical complexity (CMC) have extremely high health care needs. Given their chronic complex diagnoses and involvement of multiple care providers, they are often over medicalized and seen as a list of diagnoses rather than as a child. Parents of CMC are extraordinary caregivers and advocates for their children. Parental values and perspectives are critical drivers of medical decision making, therefore highlighting the importance of collaboration between all members of the medical team. For health care providers (HCPs) to holistically guide and support families, an all encompassing, big picture understanding of CMC and their family is needed, and care maps are one such vehicle to provide this insight. Care maps are a parent-created tool that can be used to provide a holistic view of the child and demonstrate the complexity of life and interrelatedness of services for CMC. Previous research has shown that care maps have been used as a resource to promote parental reflection and identify parental priorities of care. Promotion of care maps by HCPs as a valuable tool in understanding the child and family’s goals may help improve holistic understanding and promote collaborative care.
SICKLE modulates lateral root development by promoting degradation of lariat intronic RNA
Authors: Wu Chengyun , Wang Xiaoqing , Zhen Weibo , Nie Yaqing , Li Yan , Yuan Penglai , Liu Qiaoqiao , Guo Siyi , Shen Zhenguo , Zheng Binglian , Hu Zhubing 
Published: July 2022

AbstractPlant lateral roots (LRs) play vital roles in anchorage and uptake of water and nutrients. Here, we reveal that degradation of lariat intronic RNAs (lariRNAs) modulated by SICKLE (SIC) is required for LR development in Arabidopsis (Arabidopsis thaliana). Loss of SIC results in hyper-accumulation of lariRNAs and restricts the outgrowth of LR primordia, thereby reducing the number of emerged LRs. Decreasing accumulation of lariRNAs by over-expressing RNA debranching enzyme 1 (DBR1), a rate-limiting enzyme of lariRNA decay, restored LR defects in SIC-deficient plants. Mechanistically, SIC interacts with DBR1 and facilitates its nuclear accumulation, which is achieved through two functionally redundant regions (SIC1–244 and SIC252–319) for nuclear localization. Of the remaining amino acids in this region, six (SIC245–251) comprise a DBR1-interacting region while two (SICM246 and SICW251) are essential for DBR1–SIC interaction. Reducing lariRNAs restored microRNA (miRNA) levels and LR development in lariRNA hyper-accumulating plants, suggesting that these well-known regulators of LR development mainly function downstream of lariRNAs. Taken together, we propose that SIC acts as an enhancer of DBR1 nuclear accumulation by driving nuclear localization through direct interaction, thereby promoting lariRNA decay to fine-tune miRNA biogenesis and modulating LR development.
Single-crystal-like germanium thin films on large-area, compliant, light-weight, flexible, single-crystal-like substrates
Authors: Kim Kyunghoon , Radhakrishnan Gokul , Droopad Ravi , Goyal Amit 
Published: July 2022

Abstract
Germanium (Ge) films were heteroepitaxially grown on flexible, large-area, single-crystal-like metallic substrates. Multiple, heteroepitaxial, buffer layers of nanoscale dimensions were deposited on the triaxially textured, single-crystal-like, thermo-mechanically processed Ni–W alloy substrates. Ge films were deposited on a CeO2-terminated, heteroepitaxial buffer stack on the metallic substrate using electron beam evaporation. X-ray diffraction θ–2θ scans showed a very strong Ge (400) peak and the full width at half-maximum (FWHM) of the Ge (400) rocking curve was 0.93°. The Ge (111) ϕ-scan showed a FWHM value ∼4°. Based on the X-ray ω-scan, ϕ-scan and (111), (110), and (001) X-ray pole-figures, the Ge film deposited on the flexible, metallic substrate had a cube-on-cube heteroepitaxial relationship with the single-crystal-like metallic substrate. Reflection-high-energy-diffraction (RHEED) patterns from the Ge layer was streaky indicative of a smooth and essentially single-crystal-like Ge film. Cross-section TEM examination revealed a sharp interface between the Ge film and the topmost buffer layer, CeO2, with a low defect density. The CeO2 layer serves as a highly compliant layer that modulates its lattice parameter to attain excellent lattice-matching to the heteroepitaxial Ge layer. Ge films grown on these flexible metal substrates exhibited electron mobilities in the range of 175–250 cm2V–1s–1. Such single-crystal-like semiconductor films on low-cost, flexible, large-area, scalable, single-crystal-like metallic substrates could potentially enable high-performance electronic devices for a range of applications.
Increased Renal Expression of Complement Components in Patients With Liver Diseases: Nonalcoholic Steatohepatitis, Alcohol-Associated, Viral Hepatitis, and Alcohol-Viral Combination
Authors: Frost Kayla L , Jilek Joseph L , Thompson Austin D , Klein Robert R , Sinari Shripad , Torabzedehkorasani Elmira , Billheimer Dean D , Schnellmann Rick G , Cherrington Nathan J 
Published: July 2022

Abstract
Inflammatory liver diseases, including nonalcoholic steatohepatitis (NASH), alcohol-associated liver disease (ALD), hepatitis C virus (HCV), and ALD/HCV, account for nearly 2 million deaths annually. Despite increasing evidence that liver dysfunction impacts renal physiology, there is limited supportive clinical information, due to limited diagnosis of liver disease, complexity in liver disease etiology, and inadequacy of renal function tests. Human kidney biopsies with liver and renal pathology were obtained from patients with nonalcoholic fatty liver disease (NAFLD), NASH, ALD, HCV, and ALD/HCV (n = 5–7). Each liver disease showed renal pathology with at least 50% interstitial nephritis, 50% interstitial fibrosis, and renal dysfunction by estimated glomerular filtration rate (NAFLD 36.7 ± 21.4; NASH 32.7 ± 15.0; ALD 16.0 ± 11.0; HCV 27.6 ± 11.5; ALD/HCV 21.0 ± 11.2 ml/min/1.73 m2). Transcriptomic analysis identified 55 genes with expression changes in a conserved direction in response to liver disease. Considering association with immune regulation, protein levels of alpha-2-macroglobulin, clusterin, complement C1q C chain (C1QC), CD163, and joining chain of multimeric IgA and IgM (JCHAIN) were further quantified by LC-MS/MS. C1QC demonstrated an increase in NASH, ALD, HCV, and ALD/HCV (42.9 ± 16.6; 38.8 ± 18.4; 39.0 ± 13.5; 40.1 ± 20.1 pmol/mg protein) relative to control (19.2 ± 10.4 pmol/mg protein; p ≤ 0.08). Renal expression changes identified in inflammatory liver diseases with interstitial pathology suggest the pathogenesis of liver associated renal dysfunction. This unique cohort overcomes diagnostic discrepancies and sample availability to provide insight for mechanistic investigations on the impact of liver dysfunction on renal physiology.
I Get by With a Little Help From My Peers
Authors: Phillips Kathryn E. , Roney Linda N. 
Published: July 2022

Abstract
Graduate nursing students faced numerous stressors while pursuing their education during the COVID-19 pandemic, with many working clinically while studying. The purpose of this pilot was to explore support strategies and decrease stress in first-year students enrolled in a doctor of nursing practice program during a time of uncertainty and crisis. Graduate students were assigned to practice a three-minute mindfulness activity and connect with a fellow student for a month. Students reported mindfulness benefits and social support. Modeling healthy practices is critical to support mastery of skills that will promote positive reactions to challenges in their future practice settings.
Long-term cognitive and behavioral outcomes following early exposure to general anesthetics
Authors: Ing Caleb , Bellinger David C. 
Published: July 2022

Purpose of review
Nearly 100 clinical studies have been published evaluating neurodevelopmental outcomes in children following surgery and anesthesia. These studies have reported mixed results, likely attributable at least in part to significant heterogeneity in their study designs, types and numbers of exposures, patient populations evaluated, and most importantly, the outcomes that were assessed. This review aims to summarize the results from clinical studies evaluating behavioral outcomes in children exposed to surgery and anesthesia.

Recent findings
Children with early exposure to surgery and anesthesia were found to have limited to no differences in intelligence when compared with unexposed children. However, several studies have reported more behavioral problems in children exposed to general anesthesia. An increased incidence of attention-deficit hyperactivity disorder has also been reported in anesthetic exposed children, particularly after multiple exposures.

Summary
Nearly all clinical studies of anesthetic neurotoxicity are observational in nature, so the associations between anesthetic exposure and behavioral deficits cannot yet be directly attributed to the anesthetic medication. However, the finding of deficits in some neurodevelopmental domains and not others will help guide the selection of appropriate outcomes in future studies of anesthetic neurotoxicity that can further evaluate whether anesthetic medications have an impact on neurodevelopment in children.
Anesthesia for digestive tract endoscopy
Authors: Pardo Emmanuel , Camus Marine , Verdonk Franck 
Published: July 2022

Purpose of review
Nonoperating room anesthesia for digestive tract endoscopy has its own specificities and requires practical training. Monitoring devices, anesthetic drugs, understanding of procedures and management of complications are critical aspects.

Recent findings
New data are available regarding risk factors for intra- and postoperative complications (based on anesthesia registries), airway management, new anesthetic drugs, techniques of administration and management of advances in interventional endoscopy procedures.

Summary
Digestive tract endoscopy is a common procedure that takes place outside the operating room most of the time and has become more and more complex due to advanced invasive procedures. Prior evaluation of the patient's comorbidities and a good understanding of the objectives and constraints of the endoscopic procedures are required. Assessing the risk of gastric content aspiration is critical for determining appropriate anesthetic protocols. The availability of adequate monitoring (capnographs adapted to spontaneous ventilation, bispectral index), devices for administration of anesthetic/sedative agents (target-controlled infusion) and oxygenation (high flow nasal oxygenation) guarantees the quality of sedation and patient’ safety during endoscopic procedures. Knowledge of the specificities of each interventional endoscopic procedure (endoscopic retrograde cholangiopancreatography, submucosal dissection) allows preventing complications during anesthesia.