bluuebunny/crossref_metadata_2025_split huggingface dataset:
An Analog Comparison between Rapidly and Slowly Intensifying Tropical Cyclones
Authors: Richardson Jannetta C. , Torn Ryan D. , Tang Brian H. 
Published: July 2022

Abstract
To better understand the conditions that favor tropical cyclone (TC) rapid intensification (RI), this study assesses environmental and storm-scale characteristics that differentiate TCs that undergo RI from TCs that undergo slow intensification (SI). This comparison is performed between analog TC pairs that have similar initial intensity, vertical wind shear, and maximum potential intensity. Differences in the characteristics of RI and SI TCs in the North Atlantic and western North Pacific basins are evaluated by compositing and comparing data from the fifth-generation European Centre for Medium-Range Weather Forecasts (ECMWF) Re-Analysis (ERA5) and the Gridded Satellite (GridSat) dataset. In the period leading up to the start of RI, RI TCs tend to have a stronger and deeper vortex that is more vertically aligned than SI TCs. Additionally, surface latent heat fluxes are significantly larger in RI TCs prior to the intensity change period, compared to SI TCs. The largest surface latent heat flux differences are initially located to the left of shear; subsequently, upshear and right-of-shear differences amplify, resulting in a more symmetric distribution of surface latent heat fluxes in RI TCs. Increasing azimuthal symmetry of surface latent heat fluxes in RI TCs, together with an increasing azimuthal symmetry of horizontal moisture flux convergence, promote the upshear migration of convection in RI TCs. These differences, and their evolution before and during the intensity change period, are hypothesized to support the persistence and invigoration of upshear convection and, thus, a more symmetric latent heating pattern that favors RI.
The United Kingdom’s ‘going away to university’ migration and its changing impact on local populations in the twenty-first century
Authors: Champion Tony 
Published: July 2022

Against the background of strong growth in tertiary education globally, this paper documents the continued expansion of the United Kingdom’s higher education sector in the twenty-first century and examines the impact which the British tradition of ‘going away to university’ has been having on both the receiving and sending ends of this process. For each of the UK’s 379 local and unitary authorities, it compares the numbers of modal undergraduate age (19–21 year olds) with the number that would have been living there if the late school-age population (16–18 year olds) had merely aged in place. This approach is applied initially to 2019, with the findings then being compared with those for 2001, revealing that this migration funnels school leavers into a relatively small number of university cities and towns containing up to four times as many 19–21s as 16–18s, while siphoning off over 30% of school leavers from some of the main recruiting grounds–a pattern that has intensified since 2001. This raises questions about the future scale and nature of this process and its implications for local economies, given the current questioning of role of higher education in the UK and developments such as Brexit and the COVID-19 pandemic.
Defining Minimal Clinically Important Difference and Patient Acceptable Symptom State After the Latarjet Procedure
Authors: Menendez Mariano E. , Sudah Suleiman Y. , Cohn Matthew R. , Narbona Pablo , Lädermann Alexandre , Barth Johannes , Denard Patrick J. 
Published: July 2022

Background: The Latarjet procedure is one of the most well-established treatment options for anterior shoulder instability. However, meaningful clinical outcomes after this surgery have not been defined. Purpose: This study aimed to establish the minimal clinically important difference (MCID) and Patient Acceptable Symptom State (PASS) for commonly used outcome measures in patients undergoing the Latarjet procedure and determine correlations between preoperative patient characteristics and achievement of MCID or PASS. Study Design: Case series; Level of evidence, 4. Methods: A multicenter retrospective review at 4 institutions was performed to identify patients undergoing primary open Latarjet procedure with minimum 2-year follow-up. Data collected included patient characteristics (age, sex, sports participation), radiological parameters (glenoid bone loss, off-track Hill-Sachs lesion), and 4 patient-reported outcome measures (collected preoperatively and 2 years postoperatively): the American Shoulder and Elbow Surgeons (ASES) score, the Single Assessment Numeric Evaluation (SANE), the visual analog scale (VAS) for pain, and the Western Ontario Shoulder Instability Index (WOSI). The MCID and PASS for each outcome measure were calculated, and Pearson and Spearman coefficient analyses were used to identify correlations between MCID or PASS and preoperative variables (age, sex, sports participation, glenoid bone loss, off-track Hill-Sachs lesion). Results: A total of 156 patients were included in the study. The MCID values for ASES, SANE, VAS pain, and WOSI were calculated to be 9.6, 12.4, 1.7, and 254.9, respectively. The PASS values for ASES, SANE, VAS pain, and WOSI were 86.0, 82.5, 2.5, and 571.0, respectively. The rates of patients achieving MCID were 61.1% for VAS pain, 71.6% for ASES, 74.1% for SANE, and 84.2% for WOSI. The rates of achieving PASS ranged from 78.4% for WOSI to 84.0% for VAS pain. There was no correlation between any of the studied preoperative variables and the likelihood of achieving MCID or PASS. Conclusion: This study defined MCID and PASS values for 4 commonly used outcome measures in patients undergoing the Latarjet procedure. These findings are essential for incorporating patient perspectives into the clinical effectiveness of the Latarjet procedure and provide valuable parameters for the design and interpretation of future clinical trials.
Near infrared spectroscopy calibration strategies to predict multiple nutritional parameters of pasture species from different functional groups
Authors: Catunda Karen LM , Churchill Amber C , Power Sally A , Moore Ben D 
Published: July 2022

Near infrared reflectance (NIR) spectroscopy has been used by the agricultural industry as a rapid and inexpensive technique to quantify nutritional chemistry in plants. The aim of this study was to evaluate the performance of NIR calibrations in predicting the nutritional composition of ten pasture species that underpin livestock industries in many countries. The species comprised a range of functional diversity (C3 legumes; C3/C4 grasses; annuals/perennials) and origins (tropical/temperate; introduced/native) that grew under varied environmental conditions (control and experimentally induced warming and drought) over a period of more than two years ( n = 2622). A maximal calibration set including 391 samples was used to develop and evaluate calibrations for all ten pasture species (global calibrations), as well as for subsets comprised of the plant functional groups. This study found that the global calibrations were appropriate to predict the six key nutritional quality parameters for the studied pasture species, with the highest estimation quality found for ash (ASH), crude protein (CP), amylase-treated neutral detergent fibre (aNDF) and acid detergent fibre (ADF), and the lowest for ether extract (EE) and acid detergent lignin (ADL) parameters. The plant functional group calibrations for C3 grasses performed better than the global calibrations for ASH, CP, ADF and EE parameters, whereas for C3 legumes and C4 grasses the functional group calibrations performed less well than the global calibrations for all nutritional parameters of these groups. Additionally, the calibrations were able to capture the range of variation in forage nutritional quality caused by future climate scenarios of warming and severe drought.
Optical coherence tomography angiography (OCT angiography) in anterior ischemic optic neuropathy (AION): A systematic review and meta-analysis
Authors: Khalili Mohammad Reza , Bremner Fion , Tabrizi Reza , Bashi Ali 
Published: July 2022

Purpose To summarize the evidence available on optical coherence tomography angiography (OCTA) in patients with anterior ischemic optic neuropathy (AION). Methods Systematic searches were conducted on PubMed, Embase, Web of Science, Scopus, Cochrane, and Google Scholar Databases. The quality assessment of the included studies was performed using Newcastle -Ottawa Scale. The data were extracted to an Excel sheet. Vessel density (VD) data were pooled by random effects model, presented as pooled percentage change (PPC), and weighted mean differences (WMD). Additional subgroup analysis was also conducted. Results In initial searches in online databases, we found 3535 citations, and after screening and checking the titles and abstracts, 26 articles were ultimately eligible for our meta-analysis. The overall PPC of Intra-optic-disc (IOD) VD (−10.73%; p = 0.017, I2 = 0.0%; p = 0.898) was lower than that of radial peripapillary (RP) VD (−17.57%; p < 0.001, I2 = 44.3%; p = 0.002). The overall PPC of peripapillary choroid VD (−6.99%; p < 0.001, I2 = 0.0%; p = 0.766) was significant, but noticeably lower than the pooled percentage change of RPVD and IOD VD. The WMD of RPVD was significant when non-affected fellow eyes were compared to the healthy subjects’ eyes (−36.26; p < 0.001, I2 = 0.0%; p = 0.706). Conclusions The central retinal artery and its branches might be the main vessels which are affected in AION. The superficial retina was more affected than choroid layer in AION. Also, radial peripapillary retinal nerve fibre layer was more affected than the IOD area. OCTA might be a suitable tool for prediction of AION in susceptible eyes.
Mental representations of speech and musical pitch contours reveal a diversity of profiles in autism spectrum disorder
Authors: Wang Li , Ong Jia Hoong , Ponsot Emmanuel , Hou Qingqi , Jiang Cunmei , Liu Fang 
Published: July 2022

As an information-bearing auditory attribute of sound, pitch plays a crucial role in the perception of speech and music. Studies examining pitch processing in autism spectrum disorder have produced equivocal results. To understand this discrepancy from a mechanistic perspective, we used a novel data-driven method, the reverse-correlation paradigm, to explore whether the equivocal findings in autism spectrum disorder have high-level origins in top–down comparisons of internal mental representations of pitch contours. Thirty-two Mandarin-speaking autistic individuals and 32 non-autistic individuals undertook three subtasks testing mental representations of pitch contours in speech, complex tone and melody, respectively. The results indicate that while the two groups exhibited similar representations of pitch contours across the three conditions, the autistic group showed a significantly higher intra-group variability than the non-autistic group. In addition, the two groups did not differ significantly in internal noise, a measure of the robustness of participant responses to external variability, suggesting that the present findings translate genuinely qualitative differences and similarities between groups in pitch processing. These findings uncover for the first time that pitch patterns in speech and music are mentally represented in a similar manner in autistic and non-autistic individuals, through domain-general top–down mechanisms. Lay abstract As a key auditory attribute of sounds, pitch is ubiquitous in our everyday listening experience involving language, music and environmental sounds. Given its critical role in auditory processing related to communication, numerous studies have investigated pitch processing in autism spectrum disorder. However, the findings have been mixed, reporting either enhanced, typical or impaired performance among autistic individuals. By investigating top–down comparisons of internal mental representations of pitch contours in speech and music, this study shows for the first time that, while autistic individuals exhibit diverse profiles of pitch processing compared to non-autistic individuals, their mental representations of pitch contours are typical across domains. These findings suggest that pitch-processing mechanisms are shared across domains in autism spectrum disorder and provide theoretical implications for using music to improve speech for those autistic individuals who have language problems.
Quality of life, psychological distress, and prognostic perceptions in caregivers of patients with multiple myeloma
Authors: O’Donnell Elizabeth K. , Shapiro Yael N. , Yee Andrew J. , Nadeem Omar , Laubach Jacob P. , Branagan Andrew R. , Anderson Kenneth C. , Mo Clifton C. , Munshi Nikhil C. , Ghobrial Irene M. , Sperling Adam S. , Agyemang Emerentia A. , Burke Jill N. , Harrington Cynthia C. , Hu Bonnie Y. , Richardson Paul G. , Raje Noopur S. , El-Jawahri Areej 
Published: July 2022

Abstract
Although caregivers of patients with multiple myeloma (MM) play a critical role in supporting their loved ones throughout the illness course, studies examining caregiver quality of life (QOL), psychological distress, and prognostic awareness are lacking. We conducted a cross-sectional, multisite study of patients undergoing treatment with MM and their caregivers. Eligible caregivers were enrolled to 1 of 3 cohorts based on lines of therapy. Caregivers completed validated questionnaires to assess their QOL, psychological distress, and perceptions of prognosis. We enrolled 127 caregivers of patients with MM (newly diagnosed [n = 43], 2-3 lines of therapy [n = 40], and ≥4 lines of therapy [n = 44]). Caregiver QOL and psychological distress did not differ by line of therapy. The rate of clinically significant anxiety, depression, and posttraumatic stress disorder symptoms were 44.1% (56/127), 15.8% (20/127), and 24.4% (31/127), respectively. When examined in dyads, caregivers reported higher rates of clinically significant anxiety (44.4% [55/124] vs 22.5% [28/124]) compared with patients with MM. Most caregivers (84.2%, 101/120) reported that the oncologist had informed them that the patient’s cancer was incurable; however, only 50.9% (58/114) and 53.6% (59/110) of caregivers acknowledged the patient’s cancer was terminal and incurable, respectively. Caregivers of patients undergoing treatment for MM experience substantial psychological distress across the disease continuum, particularly anxiety. The majority of caregivers of patients with MM report that knowing the patient’s prognosis is extremely important and report that the oncologist told them that the patient was incurable. Nevertheless, a significant portion of caregivers believe that the patient’s MM is curable.
Magnetic resonance spectroscopy associations with clinicopathologic features of estrogen-dependent endometrial cancer
Authors: Zhang Jie , Liu Qingwei , Li Jie , Liu Zhiling , Wang Ximing , Li Na , Huang Zhaoqin , Xu Han 
Published: July 2022

Abstract
Background
We studied the magnetic resonance spectroscopy (MRS) associations with clinicopathologic features of estrogen-dependent endometrial cancer (type I EC).

Methods
Totally 45 patients with type I EC who underwent preoperative multi-voxel MRS at 3.0 T were enrolled. The mean ratio of the Cho peak integral to the unsuppressed water peak integral (Cho/water) of the tumor was calculated. The Cho/water and apparent diffusion coefficient (ADC) of type I EC with and without local invasion, as well as with different levels of Ki-67 staining index (SI) (≤ 40% and > 40%), were compared. Correlation test was used to examine the relationship of Cho/water, as well as mean ADC, with Ki-67 SI, tumor stage, and tumor grade.

Results
The mean Cho/water of EC with Ki-67 SI ≤ 40% (2.28 ± 0.93) × 10−3 was lower than that with Ki-67 SI > 40% (4.08 ± 1.00) × 10−3 (P < 0.001). The mean Cho/water of EC with deep and superficial myometrial invasion was (3.41 ± 1.26) × 10−3 and (2.43 ± 1.11) × 10−3, respectively (P = 0.011). There was no significant difference in Cho/water between type I EC with and without cervical invasioin ([2.68 ± 1.00] × 10−3 and [2.77 ± 1.28] × 10−3, P = 0.866). The mean Cho/water of type I EC with and without lymph node metastasis was (4.02 ± 1.90) × 10−3 and (2.60 ± 1.06) × 10−3, respectively (P = 0.014). The Cho/water was positively correlated with the Ki-67 SI (r = 0.701, P < 0.001). There were no significant differences in ADC among groups (all P > 0.05).

Conclusion
MRS is helpful for preoperative assessment of clinicopathological features of type I EC.
In-silico analysis of interacting pathways through KIM-1 protein interaction in diabetic nephropathy
Authors: Abid F. , Rubab Z. , Fatima S. , Qureshi A. , Azhar A. , Jafri A. 
Published: July 2022

Abstract
Background
Human Kidney Injury Molecule-1, also known as HAVCR-1 (Hepatitis A virus cellular receptor 1), belongs to the cell-surface protein of immunoglobulin superfamily involved in the phagocytosis by acting as scavenger receptor epithelial cells. The study focused on pinpointing the mechanisms and genes that interact with KIM-1.

Methods
This in-silico study was done from March 2019 to December 2019. The Enrichment and protein-protein interaction (PPI) network carefully choose proteins. In addition, the diagramed gene data sets were accomplished using FunRich version 3.1.3. It was done to unveil the proteins that may affect the regulation of HAVCR1 or may be regulated by this protein. These genes were then further considered in pathway analysis to discover the dysregulated pathways in diabetic nephropathy. The long list of differentially expressed genes is meaningless without pathway analysis.

Results
Critical pathways that are dysregulated in diabetic nephropathy patients have been identified. These include Immune System (Total = 237, P < 0.05), Innate Immune System (Total = 140, P < 0.05), Cytokine Signaling Immune system (Total = 116, P < 0.05), Adaptive Immune System (Total = 85) and Neutrophil degranulation (Total = 78).

Conclusion
The top 5 genes that are interacting directly with HIVCR1 include CASP3, CCL2, SPP1, B2M, and TIMP1 with degrees 161, 144, 108, 107, and 105 respectively for Immune system pathways (Innate Immune System, Cytokine Signaling Immune system, Adaptive Immune System and Neutrophil degranulation).
Preoperative chemoradiotherapy with capecitabine and triweekly oxaliplatin versus capecitabine monotherapy for locally advanced rectal cancer: a propensity-score matched study
Authors: Li Anchuan , Huang Tingxuan , Zheng Rong , Chi Pan , Li Zhihua , Wang Xiaozhong , Xu Benhua 
Published: July 2022

Abstract
Background
Distant metastasis has been the main failure pattern for locoregionally advanced rectal cancer (LARC) patients, and intensified neoadjuvant chemotherapy has become a popular research topic. The present study aimed to compare the survival outcomes, acute toxicities and surgical complications in LARC patients who received preoperative chemoradiotherapy with triweekly oxaliplatin and capecitabine (triweekly XELOX) or capecitabine.
Methods: Between 2007 and 2017, patients with clinically staged II-III rectal cancer who were treated with preoperative chemoradiotherapy using either triweekly XELOX (oxaliplatin 130 mg/m2 plus capecitabine 825 mg/m2) or capecitabine were included. Variables potentially influencing chemotherapy treatment selection were used to generate propensity scores (PS). The association between chemotherapy regimens and survival endpoints, including distant metastasis-free survival (DMFS), overall survival (OS) and disease-free survival (DFS), were evaluated and adjusted with PS. The acute toxicities and surgical complications were also compared.

Results
A total of 810 patients were included in the analysis; 277 (34.2%) patients received triweekly XELOX, and 533 (65.8%) received capecitabine. The pathological complete response (pCR) rates were 20.2 and 19.9% (P = 0.912) for the groups treated with triweekly XELOX and capecitabine, respectively. The 5-year DMFS, OS and DFS with triweekly XELOX versus capecitabine were 75.6% vs. 77.6% (P = 0.555), 79.2% vs. 83.3% (P = 0.101), and 69.9% vs. 73.7% (P = 0.283), respectively. Triweekly XELOX was not associated with an increased risk of severe toxicity during chemoradiotherapy, but it increased the risk of postoperative complications compared to capecitabine. After PS adjustment, the differences between the two groups remained insignificant in pCR rate, survival outcomes, and acute toxicities, and the difference in surgical complications disappeared.

Conclusions
Triweekly XELOX or capecitabine concurrent with neoadjuvant radiotherapy leads to similar long-term survival outcomes, acute toxicities and surgical complications in LARC patients.
Prognostic value of tumor-infiltrating lymphocytes in DCIS: a meta-analysis
Authors: Wu Shuang-Ling , Yu Xinmiao , Mao Xiaoyun , Jin Feng 
Published: July 2022

Abstract
Background
Tumor infiltrating lymphocytes (TILs) have been shown to be associated with the prognosis of breast ductal carcinoma in situ (DCIS). In this systematic review and meta-analysis, we investigated the role of TILs and TIL subsets in predicting the recurrence risk of DCIS.

Method
PubMed, Medline, Web of Science, Embase and Cochrane were searched to identify publications investigating the prognostic role of TILs in DCIS. After study screening, data extraction and risk of bias assessment, a meta-analysis was performed to assess the association between TILs (total TILs, CD4+, CD8+, FOXP3+, PD-L1+ TILs) and the risk of DCIS recurrence.

Results
A pooled analysis indicated that dense stromal TILs in DCIS were associated with a higher recurrence risk (HR 2.11 (95% CI 1.35–3.28)). Subgroup analysis showed that touching TILs (HR 4.73 (95% CI 2.28–9.80)) was more precise than the TIL ratio (HR 1.49 (95% CI 1.11–1.99)) in estimating DCIS recurrence risk. Moreover, the prognostic value of TILs seemed more suitable for patients who are diagnosed with DCIS and then undergo surgery (HR 2.77, (95% CI 1.26–6.07)) or surgery accompanied by radiotherapy (HR 2.26, (95% CI 1.29–3.95)), than for patients who receive comprehensive adjuvant therapies (HR 1.16, (95% CI 1.35–3.28)). Among subsets of TILs, dense stromal PD-L1+ TILs were valuable in predicting higher recurrence risk of DCIS.

Conclusion
This systematic review and meta-analysis suggested a non-favorable prognosis of TILs and stromal PD-L1+ TILs in DCIS and indicated an appropriate assessment method for TILs and an eligible population.