bluuebunny/crossref_metadata_2025_split huggingface dataset:
Coupling field-scale and watershed models for regulatory modeling of pesticide aquatic exposures in streams
Authors: Ghebremichael Lula , Chen Wenlin , Jacobson Andy , Roy Colleen , Perkins Daniel B. , Brain Richard 
Published: February 2022

Abstract
Estimating exposure in receiving waterbodies is a key step in the regulatory process to evaluate potential ecological risks posed by the use of agricultural pesticides. The United States Environmental Protection Agency (USEPA) currently uses the Variable Volume Water Model (VVWM) to predict environmental concentrations of pesticides in static waterbodies (ponds) that receive edge-of-field runoff inputs from the Pesticide Root Zone Model (PRZM). This regulatory model, however, does not adequately characterize potential pesticide concentrations in flowing water systems (streams and rivers) drained from watershed areas. This study aims at addressing this gap by coupling the regulatory PRZM model with a watershed-level hydrological model, the Soil and Water Assessment Tool (SWAT), to predict pesticide concentrations in flowing water habitats for aquatic organisms. This coupled PRZM-SWAT model was applied in a test watershed (~HUC12), a headwater watershed of Goodwater Creek in Missouri, and simulation results at the outlet of this watershed were compared to daily and near-daily measured streamflow and atrazine concentration data from a decade-long sampling campaign. Overall, the PRZM-SWAT model captured (1) the general magnitude and temporal trend of daily atrazine concentrations, (2) the observed high-end of exposure levels (&gt;3 ppb) of atrazine concentrations, and (3) the 90th centile annual maximum for various exposure durations (1-, 4-, 7-, 21-, and 60-day rolling average), which are important exposure metrics used in assessing the potential ecological risks posed by the application of pesticides. The PRZM-SWAT model is expected to expand the utility of the field-scale regulatory model to include pesticide exposure prediction capability in flowing waterbodies from agricultural watersheds. Integr Environ Assess Manag 2022;18:1678–1693. © 2022 SETAC
KEY POINTS
A coupled PRZM-SWAT modeling approach that integrates a field-level pesticide model with a watershed-level hydrological model was developed for estimating surface runoff-driven pesticide exposure estimates in flowing waterbodies that are needed for refined ecological risk assessment. The coupled PRZM-SWAT model performed well in estimating atrazine exposure levels in flowing waterbodies (mainly the high end of exposure levels, &gt;3 ppb), needed for conducting ecological risk assessments.
Acute aerobic exercise‐conditioned serum reduces colon cancer cell proliferation in vitro through interleukin‐6‐induced regulation of DNA damage
Authors: Orange Samuel T. , Jordan Alastair R. , Odell Adam , Kavanagh Owen , Hicks Kirsty M. , Eaglen Tristan , Todryk Stephen , Saxton John M. 
Published: February 2022

AbstractEpidemiological evidence shows that regular physical activity is associated with reduced risk of primary and recurrent colon cancer. However, the underlying mechanisms of action are poorly understood. We evaluated the effects of stimulating a human colon cancer cell line (LoVo) with human serum collected before and after an acute exercise bout vs nonexercise control serum on cancer cell proliferation. We also measured exercise‐induced changes in serum cytokines and intracellular protein expression to explore potential biological mechanisms. Blood samples were collected from 16 men with lifestyle risk factors for colon cancer (age ≥50 years; body mass index ≥25 kg/m2; physically inactive) before and immediately after an acute bout of moderate‐intensity aerobic interval exercise (6 × 5 minutes intervals at 60% heart rate reserve) and a nonexercise control condition. Stimulating LoVo cells with serum obtained immediately after exercise reduced cancer cell proliferation compared to control (−5.7%; P = .002). This was accompanied by a decrease in LoVo cell γ‐H2AX expression (−24.6%; P = .029), indicating a reduction in DNA damage. Acute exercise also increased serum IL‐6 (24.6%, P = .002). Furthermore, stimulating LoVo cells with recombinant IL‐6 reduced γ‐H2AX expression (β = −22.7%; P < .001) and cell proliferation (β = −5.3%; P < .001) in a linear dose‐dependent manner, mimicking the effect of exercise. These findings suggest that the systemic responses to acute aerobic exercise inhibit colon cancer cell proliferation in vitro, and this may be driven by IL‐6‐induced regulation of DNA damage and repair. This mechanism of action may partly underlie epidemiological associations linking regular physical activity with reduced colon cancer risk.
The transfer of vaccine‐generated SARS‐CoV‐2 antibodies into infantile circulation via breastmilk
Authors: Lebbe Barbara , Reynders Marijke , Van Praet Jens T. 
Published: February 2022

The contents of this page will be used as part of issue TOC only. It will not be published as part of main articleVaccine‐generated maternal anti‐SARS‐CoV‐2 IgG antibodies are not transferred into infantile circulation via breastmilk.
Impact of the introduction of a low‐cost uterine balloon tamponade (ESM‐UBT) device for managing severe postpartum hemorrhage in India: A comparative before‐and‐after study
Authors: Burke Thomas F. , Shivkumar Poonam V. , Priyadarshani Preeti , Garg Lorraine , Conde‐Agudelo Agustin , Guha Moytrayee 
Published: February 2022

AbstractObjectiveTo evaluate the impact of introducing a uterine balloon tamponade (ESM‐UBT) device for managing severe postpartum hemorrhage (PPH), mainly due to uterine atony, in health facilities in India on the rates of PPH‐related maternal death and invasive procedures for PPH control.MethodsWe used a quasi‐experimental, difference‐in‐difference (DID) design to compare changes in the rates of a composite outcome (PPH‐related maternal death and/or artery ligation, uterine compression sutures, or hysterectomy) among women delivering in nine intervention facilities compared with those delivering in two control facilities, before and after the introduction of ESM‐UBT.ResultsThe study sample included 214 123 deliveries (n = 78 509 before ESM‐UBT introduction; n = 47 211 during ESM‐UBT introduction; and n = 88 403 after ESM‐UBT introduction). After introduction of ESM‐UBT, there was a significant decline in the rate of the primary composite outcome in intervention facilities (21.0–11.4 per 10 000 deliveries; difference −9.6, 95% confidence interval −14.0 to −5.4). Change in the rate of the primary composite outcome was not significant in control facilities (11.7–17.2 per 10 000 deliveries; difference 5.4, 95% confidence interval −3.9 to 14.9). DID analyses showed there was a significant reduction in the rate of the primary composite outcome in intervention facilities relative to control facilities (adjusted DID estimate −15.0 per 10 000 points, 95% confidence interval −23.3 to −6.8; P = 0.005).ConclusionIntroduction of the ESM‐UBT in health facilities in India was associated with a significant reduction in PPH‐related maternal death and/or invasive procedures for PPH control.
The feasibility of switching from IVF to IVM combined with all‐blastocyst‐culture and transfer for patients with ovarian hyperstimulation syndrome tendency
Authors: Zhao Fanxuan , Lu Xiaosheng , Gong Chaochao , Xi Haitao , Liu Xiaoming , Zhao Junzhao 
Published: February 2022

AbstractObjectiveTo investigate the feasibility of switching from in vitro fertilization (IVF) to in vitro maturation (IVM) combined with all‐blastocyst‐culture and transfer as a supplementary infertility treatment in patients with ovarian hyperstimulation syndrome (OHSS) tendencyMethodsRetrospective cohort study including 184 patients who switched from IVF and underwent 192 IVM cycles between January 2016 and December 2020. The outcomes were compared between cleavage‐stage embryo transfer (group A, n = 74) and blastocyst‐stage transfer (group B, n = 52) groups.ResultsThe OHSS rate is 0%. 66 cycles were canceled for transfer. Among the 126 transfer cycles, number of retrieved oocytes, proportion of metaphase II oocytes, cleavage rate, and proportion of high‐quality embryos on day 3 post‐fertilization are significantly lower in group A than that in group B. On the contrary, number of transferred embryos is significantly lower in group B than that in group A, whereas the rates of implantation, clinical pregnancy, and live births are significantly higher in group B than that in group A.ConclusionTimely switching to IVM combined with all‐blastocyst‐culture and transfer for patients undergoing controlled ovarian hyperstimulation and exhibiting characteristics of OHSS tendency is feasible as a supplementary infertility treatment.
Clinicopathologic features of pregnancy luteoma
Authors: Wang Lixin , Zhou Chen , Jiang Jingui , Zhang Zilan , Li Xiaohong , Zhang Weishan 
Published: February 2022

AbstractObjectiveThis study aimed to explore the clinicopathological characteristics, immunophenotype, histological occurrence, diagnosis, and differential diagnosis of ovarian luteoma tumor of pregnancy.MethodsThe clinical features, histomorphology, immunohistochemistry, and reticular fiber staining results of 18 cases of luteoma tumors of pregnancy were analyzed, and related published studies were reviewed.ResultsThe 18 cases of luteoma tumors were all women who had undergone multiple pregnancies. The tumors were 1.3–15 cm in size and brownish yellow or reddish brown in color, with a soft texture. Microscopic examination revealed the eosinophilic cytoplasm of tumor cells and diffuse hyperplasia. The results of the immunohistochemical analysis were as follows: α‐inhibin, AE1/AE3, CD99, and vimentin were positive, while epithelial membrane antigen, S‐100, HMB45, and MelanA were negative. One case was positive for MelanA. The staining results of reticular fibers showed that the argyrophilic reticular fibers were black surrounding the tumor cell nests.ConclusionsLuteoma tumor of pregnancy is a rare tumor‐like lesion mostly appearing in late pregnancy. The gross, immunohistochemical staining, and reticular fiber staining results may help diagnose this disease. The disease needs to be differentiated from other diseases.
Comparative evaluation on the toxic effect of silver (Ag) and zinc oxide (ZnO) nanoparticles on different trophic levels in aquatic ecosystems: A review
Authors: Sibiya Ashokkumar , Jeyavani Jeyaraj , Santhanam Perumal , Preetham Elumalai , Freitas Rosa , Vaseeharan Baskaralingam 
Published: February 2022

AbstractSilver (Ag) and zinc oxide (ZnO) are considered to be harmful nanoparticles (NPs) to the aquatic organisms as their intake causes toxic impacts to wildlife, through direct ingestion or by the transference along trophic levels. Over usage and ultimate disposal of metallic particles from the industries subsequently lead to pollution of the aquatic environment. Exposure of NPs in aquatic ecosystem alters biological and physicochemical parameters of the water and aquatic organisms and determines their potential ecotoxicological impacts. Prolonged exposure of aquatic organisms to these NPs results in differential bioaccumulation and distribution into internal organs like liver, kidney, gills, brain, and muscle tissue. The contact of NPs to aquatic organisms induces various types of toxic traits including cytotoxicity, genotoxicity, and epigeneticity. Taking this in consideration, this present review focuses on the comparative toxic impact of ZnO and Ag NPs towards both vertebrates and invertebrates in aquatic ecosystems.
Dose–response relationships of sarcopenia parameters with incident disability and mortality in older Japanese adults
Authors: Seino Satoshi , Kitamura Akihiko , Abe Takumi , Taniguchi Yu , Murayama Hiroshi , Amano Hidenori , Nishi Mariko , Nofuji Yu , Yokoyama Yuri , Narita Miki , Shinkai Shoji , Fujiwara Yoshinori 
Published: February 2022

AbstractBackgroundSarcopenia‐related parameters may have differential impacts on health‐related outcomes in older adults. We examined dose–response relationships of body composition, muscle strength, and physical performance with incident disability and mortality.MethodsThis prospective study included 1765 Japanese residents (862 men; 903 women) aged ≥65 years who participated in health check‐ups. Outcomes were incident disability and all‐cause mortality. Fat mass index (FMI) and skeletal muscle mass index (SMI), determined using segmental multi‐frequency bioelectrical impedance analysis, handgrip strength (HGS), and usual gait speed (UGS) were measured. We determined multivariate‐adjusted hazard ratios (HRs) for disability and mortality relative to sex‐specific reference values (FMI: medians; SMI: 7.0 kg/m2 for men and 5.7 kg/m2 for women; HGS: 28 kg for men and 18 kg for women; or UGS: 1.0 m/s for both sexes). Association shapes were examined using restricted cubic splines or fractional polynomial functions.ResultsThe median follow‐up was 5.3 years; 107 (12.7%) men and 123 (14.2%) women developed disability, and 101 (11.7%) men and 56 (6.2%) women died. FMI did not impact any outcome in men and disability in women, while an FMI ≤ 7.3 kg/m2 (median) was significantly associated with higher mortality risk in women, compared with median FMI. SMI did not impact disability in either sex and mortality in women, but showed a significant inverse dose–response relationship with mortality risk in men [HRs (95% confidence intervals) of minimum and maximum values compared with the reference value: 2.18 (1.07–4.46) and 0.43 (0.20–0.93), respectively], independent of HGS and UGS. HGS and UGS showed a significant inverse dose–response relationship with disability in both sexes [HGS: 1.71 (1.00–2.91) and 0.31 (0.09–0.99), respectively, in men, 2.42 (1.18–4.96) and 0.41 (0.20–0.85), respectively, in women; UGS: 2.14 (1.23–3.74) and 0.23 (0.08–0.67), respectively, in men, 3.26 (2.07–5.14) and 0.11 (0.05–0.26), respectively, in women] and mortality in women [HGS: 6.84 (2.84–16.47) and 0.06 (0.02–0.21), respectively; UGS: 2.67 (1.14–6.27) and 0.30 (0.11–0.85), respectively], independent of body composition, but did not impact mortality in men.ConclusionsDisability risk was more dependent on muscle strength and physical performance in both sexes. Mortality risk in men was more dependent on muscle mass, and mortality risk in women was influenced by lower fat mass along with muscle strength and physical performance. Although improving muscle strength and physical performance should be the first target for health promotion, it is also necessary to pay attention to body composition to extend life expectancy in older adults.
Feasibility of iron‐based sorbents for arsenic removal from groundwater
Authors: Gonzalez‐Pech Natalia I , Molloy Anna L , Zambrano Alexandra , Lin Wayne , Bohloul Arash , Zarate‐Araiza Rafael , Avendano Carolina , Colvin Vicki L 
Published: February 2022

AbstractBACKGROUNDArsenic is one of the most serious drinking water contaminants around the world. The development of iron oxide materials, including nanoparticles, as sorbents for arsenic remediation has shown promising results in recent years. Some of these materials are already used as commercial‐grade arsenic sorbents. However, the use of iron‐oxide nanoparticles (IONPs) has barely been used in real‐world conditions. This work compares commercial IONPs with three proven arsenic sorbents.RESULTSThe full chemical characterization includes electron microscopy, X‐ray diffraction and X‐ray photon spectroscopy to determine morphology, crystalline structure and elemental analysis, respectively. Arsenic remediation studies also were conducted in both batch and column set‐ups with real water samples from Salamanca, Mexico. The conditions (pH 8, high concentration of silica and presence of other interferences) found in this site are outside the recommended parameters of operations for most of the arsenic sorbents. All of the materials observed a negative effect because of silica presence. However, the effects observed in batch did not correlate directly to the column tests. This is important when evaluating the viability of using sorbents in specific conditions.CONCLUSIONSA feasibility analysis revealed that some commercial sorbents can treat water with the conditions presented in the selected site, but the cost of treatment is not viable for developing countries. In addition, the generated waste by using these sorbents would be substantial. These challenges could be diminished by using nanoparticles, yet the commercially‐available IONPs do not fill this gap. Better designed nanomaterials are still needed for arsenic removal. © 2022 Society of Chemical Industry (SCI).
5‐Sulfosalicylicacid an organocatalyst for the synthesis of highly functionalized piperidines through the multicomponent reaction
Authors: Gadge Dhananjay D. , Kulkarni Pramod S. 
Published: February 2022

AbstractThe synthetic protocol was developed for the synthesis of highly derivatized piperidines molecules in high yield with 5‐sulfosalicylic acid as an organocatalyst via a multicomponent reaction between the aromatic aldehydes, the aromatic anilines, and the β‐ketoesters at room temperature. The method has numerous advantages over other reported methods, such as the use of an inexpensive, reusable, nontoxic, and metal‐free catalyst along with readily available precursors, mild reaction conditions, and simple workup procedures. Instrumental techniques like high‐resolution mass spectroscopy (HRMS), proton nuclear magnetic resonance (1H NMR), 13‐carbon nuclear magnetic resonance (13C NMR), and Fourier transform infrared (FTIR) spectroscopy were used to confirm the structure and relative stereochemistry of the compounds. In this protocol, an anti‐isomer has been obtained as a major product at room temperature. Syn: Anti diastereomeric ratio has been confirmed by1H NMR.
A cross‐sectional study of SARS‐CoV‐2 seropositivity among healthcare workers and residents of long‐term facilities in Italy, January 2021
Authors: Bordino Valerio , Marengo Noemi , Garlasco Jacopo , Cornio Alessandro Roberto , Meddis Davide , Ditommaso Savina , Giacomuzzi Monica , Memoli Gabriele , Gianino Maria Michela , Vicentini Costanza , Zotti Carla Maria ,   Collaborating group
Published: February 2022

AbstractLong‐term care facilities (LTCFs) are high‐risk settings for SARS‐CoV‐2 infection. This study aimed to describe SARS‐CoV‐2 seropositivity among residents of LTCFs and health‐care workers (HCWs). Subjects were recruited in January 2021 among unvaccinated HCWs of LTCFs and hospitals and residents of LTCFs in Northern Italy. Information concerning previous SARS‐CoV‐2 infections and a sample of peripheral blood were collected. Anti‐S SARS‐CoV‐2 IgG antibodies were measured using the EUROIMMUN Anti‐SARS‐CoV‐2 QuantiVac ELISA kit (EUROIMMUN Medizinische Labordiagnostika AG). For subjects with previous COVID‐19 infection, gender, age, type of subject (HCW or resident), and time between last positive swab and blood draw were considered as possible determinants of two outcomes: the probability to obtain a positive serological result and antibody titer. Six hundred and fifty‐eight subjects were enrolled. 56.1% of all subjects and 65% of residents presented positive results (overall median antibody titer: 31.0 RU/ml). Multivariable models identified a statistically significant 4% decrease in the estimated antibody level for each 30‐day increase from the last positive swab. HCWs were associated with significant odds for seroreversion over time (OR: 0.926 for every 30 days, 95% CI: 0.860–0.998), contrary to residents (OR: 1.059, 95% CI: 0.919–1.22). Age and gender were not factors predicting seropositivity over time. Residents could have a higher probability of maintaining a seropositive status over time compared to HCWs.
TET2 is required for Type I IFN‐mediated inhibition of bat‐origin swine acute diarrhea syndrome coronavirus
Authors: Duan Yueyue , Yuan Cong , Suo Xuepeng , Cao Liyan , Kong Xiangyu , Li Xiangtong , Zheng Haixue , Wang Qi 
Published: February 2022

AbstractSwine acute diarrhea syndrome coronavirus (SADS‐CoV) is a newly discovered bat‐origin coronavirus with fatal pathogenicity for neonatal piglets. There is no vaccine to prevent SADS‐CoV infection or clinically approved drugs targeting SADS‐CoV. Therefore, unraveling cellular factors that regulate SADS‐CoV for cell entry is critical to understanding the viral transmission mechanism and provides a potential therapeutic target for SADS‐CoV cure. Here, we showed that Type I interferon (IFN‐I) pretreatment potently blocks SADS‐CoV entry into cells using lentiviral pseudo‐virions as targets whose entry is driven by the SADS‐CoV Spike glycoprotein. IFN‐I‐mediated inhibition of SADS‐CoV entry and replication was dramatically impaired in the absence of TET2. These results suggest TET2 is found to serve as a checkpoint of IFN‐I‐meditated inhibition on the cell entry of SADS‐CoV, and our discovery might constitute a novel treatment option to combat against SADS‐CoV.
Comparison of performance between three SARS‐CoV‐2 molecular assays (Aptima™, Laboratory Developed Test‐Fusion, and R‐GENE®) with special attention to turnaround time, a key point in laboratory management
Authors: Lefeuvre Caroline , Pivert Adeline , Przyrowski Emilie , Bouthry Elise , Darviot Estelle , Mahieu Rafaël , Lunel‐Fabiani Françoise , Ducancelle Alexandra , Le Guillou‐Guillemette Hélène 
Published: February 2022

AbstractThe emergence of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) highlights the importance of rapid diagnostic testing to identify individuals with SARS‐CoV‐2 infections and to limit the spread of the virus. Many molecular assays have become commercially available to cope with this surging demand for timely diagnosis of COVID‐19 cases, but identifying individuals requires accurate diagnostic tools. We compared the performance of three molecular SARS‐CoV‐2 assays: Aptima™ SARS‐CoV‐2 assay running on the Panther system (Hologic), an in‐house assay (Laboratory Developed Test, LDT) running on the Fusion module of the Panther Fusion system (LDT‐Fusion; Hologic), and the R‐GENE® SARS‐CoV‐2 assay (bioMérieux). In addition, we also evaluated the turnaround time. This parameter is crucial to managing the SARS‐CoV‐2 diagnosis and represents a key point in the quality management at the laboratory. Aptima™ and LDT‐Fusion assays exhibited an excellent positive percent agreement (PPA) (100.0%), while the R‐GENE® assay showed a slightly decreased PPA (98.2%). The Hologic assays have a higher throughput with less hands‐on time than the R‐GENE® assays (24–25 vs. 71 min). Both Hologic assays are used on a fully automated random‐access testing system with on‐demand testing capabilities that avoid run series, unlike the R‐GENE® assay. Automated random‐access testing systems should be preferred during periods of high SARS‐CoV‐2 prevalence.