bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hotspots and Frontiers in Inflammatory Tumor Microenvironment Research: A Scientometric and Visualization Analysis
Authors: Zhang Yuli , Huo Long , Wei Zhenzhen , Tang Qingfeng , Sui Hua 
Published: March 2022

Methods: Articles on inflammatory tumor microenvironment were retrieved from the Web of Science Core Collection, and the characteristics of the articles were analyzed by CiteSpace software.Background: The inflammatory tumor microenvironment is an essential feature of the tumor microenvironment. The way in which it promotes or inhibits tumor progression plays an important role in the outcome of a tumor treatment. This research aims to explore a scientific collaboration network, describe evolution of hotspots, and predict future trends through bibliometric analysis.Results: A total of 3,534 papers published by 390 institutions in 81 countries/regions were screened, and the annual quantity has been increasing rapidly in the past decades. United States was the leading country and has the most productive institutions in this field. The research topics were mainly focused on inflammation and immunity mediated by crucial factors as well as the mechanisms of angiogenesis. Additionally, the development and application of nanoparticles is currently a novel research frontier with bright prospect.Conclusion: The present scientometric study provides an overview of inflammatory tumor microenvironment research over the previous decades using quantitative and qualitative methods, and the findings of this study can provide references for researchers focusing on tumor treatment.
Serum and Urinary Neutrophil Gelatinase-Associated Lipocalin Are Not Associated With Serum Redox Parameters in Amateur Athletes After an Ultramarathon
Authors: Loureiro Adriano César Carneiro , Nocrato Gabriella Fontenele , Correia André Luis Lima , de Matos Robson Salviano , Filho Júlio César Chaves Nunes , Daher Elisabeth De Francesco , Pinto Flávio Henrique Macedo , de Oliveira Ariclécio Cunha , Ceccatto Vania Marilande , Fortunato Rodrigo Soares , de Carvalho Denise Pires 
Published: March 2022

ObjectiveTo evaluate the relationship between oxidative stress and NGAL levels in blood and urine of amateur athletes after participating in a 100 km ultramarathon.MethodologyThe sample was composed of seven athletes, submitted to anthropometric assessment, cardiopulmonary exercise test, collection of urine and blood, measurement of body weight. The rate of perceived exertion (RPE), competition duration, heart rate (HR), energy expenditure and oxygen consumption (V’O2”) were also measured during the event. The energy consumption during the race was verified at its end. The analyses were based on the means (M) and respective standard deviations (SD), with statistical significance set at 5% (p &lt; 0.05). Paired t-test was used for comparison between the periods before and after the competition, and Pearson’s correlation coefficient was used to measure the linear correlation between quantitative variables.ResultsBody mass index (BMI) of the sample was 25.75 kg/m2 ± 3.20, body fat percentage 18.54% ± 4.35% and V’O2”max 48.87% ± 4.78. Glucose, cortisol, and neutrophil gelatinase-associated lipocalin (NGAL) (p &lt; 0.01) as well as glutathione peroxidase (GPx) active were higher after the race when compared to basal values. Moreover, lactate, creatinine, microalbuminuria, and glomerular filtration rate (GFR) (p &lt; 0.001) were also higher after the race. After the competition, there was a significant correlation only between serum NGAL and creatinine, which was classified as strong and positive (r: 0.77; p &lt; 0.05). There was a significant reduction (p &lt; 0.05) of body weight after the event (72.40 kg ± 9.78) compared to before it (73.98 kg ± 10.25). In addition, we found an increase of RPE (p &lt; 0.001) after the race. The competition lasted 820.60 min (±117.00), with a 127.85 bpm (±12.02) HR, a 2209.72 kcal ± 951.97 energy consumption, 7837.16 kcal ± 195.71 energy expenditure, and 28.78 ml/kg/min–1 (±4.66) relative V’O2”max.ConclusionThe lack of correlation between oxidative stress biomarkers and serum and urine NGAL suggests that NGAL is more sensitive to inflammatory processes than to ROS levels.
Sodium Butyrate Attenuates Taurocholate-Induced Acute Pancreatitis by Maintaining Colonic Barrier and Regulating Gut Microorganisms in Mice
Authors: Xiong Yangyang , Ji Li , Zhao Yi , Liu Ailing , Wu Dong , Qian Jiaming 
Published: March 2022

BackgroundAcute pancreatitis (AP) damages the intestinal barrier, which aggravates AP. Butyrate exhibits anti-inflammatory effects in AP, but it is unknown if such a protective effect is associated with the regulation of gut microorganisms. We aim to investigate the effects of sodium butyrate (SB) on pancreatic inflammation, colonic barrier, and gut microorganisms.MethodsC57BL/6 mice were divided into groups of sham operation (Sham), AP, 200 mg/kg SB intervention (SB-200), and 500 mg/kg SB intervention group (SB-500). Samples were harvested 24 h after the model was established. The gut microbiota was analyzed using 16S rRNA gene sequencing.ResultsPancreatic infiltration of neutrophils, macrophages, and M2-type macrophages was significantly reduced in the SB-500 intervention group. Supplementation of SB-500 improved colon mucosal histology and the expression of ZO-1 and occluding. The relative abundance of Alloprevotella and Muribaculaceae was increased and that of Akkermansia was decreased in the SB-500 group compared with the AP group. Ruminococcaceae was the most significantly increased species and Prevotellaceae was the most significantly decreased species in the SB-500 group compared with the AP group.ConclusionHigh dose of SB inhibits pancreatic inflammation probably by maintaining the intestinal barrier and regulating gut microbiota in mice with AP.
A Cross-Sectional Study of Individual Learning Passion in Medical Education: Understanding Self-Development in Positive Psychology
Authors: Zhang Shu-e , Ge Si-ao , Tian Jing , Li Qing-lin , Wang Ming-si , Wang Xiao-he , Zhang Meng , Zhao Ji-yang , Yang Li-bin , Cao De-pin , Sun Tao 
Published: March 2022

BackgroundBoosting the individual learning passion of medical students is a novel approach to improve their academic performance. It facilitates the medical education reform, motivating both policymakers and educators to focus on the function of positive psychology in the career development of medical students. Therefore, this study aimed (1) to assess the status of two types of learning passion; (2) to clarify the relationship between self-esteem and two types of learning passion among Chinese medical students; (3) to examine the mediating role of psychological capital (PsyCap) in the relationship between self-esteem and two types of learning passion, respectively; and (4) to identify the moderating role of professional identity in the relationship between PsyCap and two types of learning passion, respectively.MethodsA cross-sectional online survey was conducted from April to June 2016 in China. A total of 1,218 valid questionnaires (effective completion rate: 67.93%) were collected from four medical schools.ResultsSelf-esteem significantly and positively influenced medical students’ PsyCap (β = 0.637, P &lt; 0.01) and two types of learning passion, including harmonious learning passion (β = 0.589, P &lt; 0.01) and obsessive learning passion (β = 0.436, P &lt; 0.01). PsyCap fully mediated the relationship (β = 0.578, P &lt; 0.01) between self-esteem and harmonious learning passion positively, whereas it suppressed the relationship (β = 0.490, P &lt; 0.01) between self-esteem and obsessive learning passion. Further, professional identity significantly moderated the correlation between PsyCap and harmonious learning passion (β = −0.554, P &lt; 0.05), rather than obsessive learning passion (P &gt; 0.05).ConclusionTwo types of learning passion of medical students are positively influenced by self-esteem and PsyCap. Medical students with high-level self-esteem should possess strong PsyCap, which augments their harmonious as well as obsessive learning passion. Moreover, the positive effect of medical students’ PsyCap on harmonious learning passion is more notable among those with a lower professional identity. Finally, this study argues that strengths-based interventions of self-esteem and PsyCap are a beneficial approach for future enhancing learning passion in the domain of medical education.
A Data-Driven Clustering Method for Discovering Profiles in the Dynamics of Major Depressive Disorder Using a Smartphone-Based Ecological Momentary Assessment of Mood
Authors: van Genugten Claire R. , Schuurmans Josien , Hoogendoorn Adriaan W. , Araya Ricardo , Andersson Gerhard , Baños Rosa M. , Berger Thomas , Botella Cristina , Cerga Pashoja Arlinda , Cieslak Roman , Ebert David D. , García-Palacios Azucena , Hazo Jean-Baptiste , Herrero Rocío , Holtzmann Jérôme , Kemmeren Lise , Kleiboer Annet , Krieger Tobias , Rogala Anna , Titzler Ingrid , Topooco Naira , Smit Johannes H. , Riper Heleen 
Published: March 2022

BackgroundAlthough major depressive disorder (MDD) is characterized by a pervasive negative mood, research indicates that the mood of depressed patients is rarely entirely stagnant. It is often dynamic, distinguished by highs and lows, and it is highly responsive to external and internal regulatory processes. Mood dynamics can be defined as a combination of mood variability (the magnitude of the mood changes) and emotional inertia (the speed of mood shifts). The purpose of this study is to explore various distinctive profiles in real-time monitored mood dynamics among MDD patients in routine mental healthcare.MethodsEcological momentary assessment (EMA) data were collected as part of the cross-European E-COMPARED trial, in which approximately half of the patients were randomly assigned to receive the blended Cognitive Behavioral Therapy (bCBT). In this study a subsample of the bCBT group was included (n= 287). As part of bCBT, patients were prompted to rate their current mood (on a 1–10 scale) using a smartphone-based EMA application. During the first week of treatment, the patients were prompted to rate their mood on three separate occasions during the day. Latent profile analyses were subsequently applied to identify distinct profiles based on average mood, mood variability, and emotional inertia across the monitoring period.ResultsOverall, four profiles were identified, which we labeled as: (1) “very negative and least variable mood” (n= 14) (2) “negative and moderate variable mood” (n= 204), (3) “positive and moderate variable mood” (n= 41), and (4) “negative and highest variable mood” (n= 28). The degree of emotional inertia was virtually identical across the profiles.ConclusionsThe real-time monitoring conducted in the present study provides some preliminary indications of different patterns of both average mood and mood variability among MDD patients in treatment in mental health settings. Such varying patterns were not found for emotional inertia.
Application of Artificial Intelligence on Psychological Interventions and Diagnosis: An Overview
Authors: Zhou Sijia , Zhao Jingping , Zhang Lulu 
Published: March 2022

BackgroundInnovative technologies, such as machine learning, big data, and artificial intelligence (AI) are approaches adopted for personalized medicine, and psychological interventions and diagnosis are facing huge paradigm shifts. In this literature review, we aim to highlight potential applications of AI on psychological interventions and diagnosis.MethodsThis literature review manifest studies that discuss how innovative technology as deep learning (DL) and AI is affecting psychological assessment and psychotherapy, we performed a search on PUBMED, and Web of Science using the terms “psychological interventions,” “diagnosis on mental health disorders,” “artificial intelligence,” and “deep learning.” Only studies considering patients' datasets are considered.ResultsNine studies met the inclusion criteria. Beneficial effects on clinical symptoms or prediction were shown in these studies, but future study is needed to determine the long-term effects.LimitationsThe major limitation for the current study is the small sample size, and lies in the lack of long-term follow-up-controlled studies for a certain symptom.ConclusionsAI such as DL applications showed promising results on clinical practice, which could lead to profound impact on personalized medicine for mental health conditions. Future studies can improve furthermore by increasing sample sizes and focusing on ethical approvals and adherence for online-therapy.
Mapping Network Connectivity Among Symptoms of Depression and Pain in Wuhan Residents During the Late-Stage of the COVID-19 Pandemic
Authors: Yang Yuan , Zhang Shu-Fang , Yang Bing Xiang , Li Wen , Sha Sha , Jia Fu-Jun , Cheung Teris , Zhang De-Xing , Ng Chee H. , Xiang Yu-Tao 
Published: March 2022

BackgroundSymptoms of depression and pain often overlap, and they negatively influence the prognosis and treatment outcome of both conditions. However, the comorbidity of depression and pain has not been examined using network analysis, especially in the context of a pandemic. Thus, we mapped out the network connectivity among the symptoms of depression and pain in Wuhan residents in China during the late stage of the COVID-19 pandemic.MethodsThis cross-sectional study was conducted from May 25, 2020 to June 18, 2020 in Wuhan, China. Participants' depressive and pain symptoms were assessed using the 9-item Patient Health Questionnaire (PHQ9) and a pain numeric rating scale (NRS), respectively. Network analyses were performed.ResultsIn total, 2,598 participants completed all assessments. PHQ4 (fatigue) in the depression community showed the highest strength value, followed by PHQ6 (worthlessness) and PHQ2 (depressed or sad mood). PHQ4 (fatigue) was also the most key bridge symptom liking depression and pain, followed by PHQ3 (sleep difficulties). There were no significant differences in network global strength (females: 4.36 vs. males: 4.29; S = 0.075, P = 0.427), network structure-distribution of edge weights (M = 0.12, P = 0.541), and individual edge weights between male and female participants.ConclusionDepressive and pain symptoms showed strong cross-association with each other. “Fatigue” was the strongest central and bridge symptom in the network model, while “sleep difficulties” was the second strongest bridge symptom. Targeting treatment of both fatigue and sleep problems may help improve depressive and pain symptoms in those affected.
A Data-Driven Framework for Identifying Intensive Care Unit Admissions Colonized With Multidrug-Resistant Organisms
Authors: Çaǧlayan Çaǧlar , Barnes Sean L. , Pineles Lisa L. , Harris Anthony D. , Klein Eili Y. 
Published: March 2022

BackgroundThe rising prevalence of multi-drug resistant organisms (MDROs), such as Methicillin-resistant Staphylococcus aureus (MRSA), Vancomycin-resistant Enterococci (VRE), and Carbapenem-resistant Enterobacteriaceae (CRE), is an increasing concern in healthcare settings.Materials and MethodsLeveraging data from electronic healthcare records and a unique MDRO universal screening program, we developed a data-driven modeling framework to predict MRSA, VRE, and CRE colonization upon intensive care unit (ICU) admission, and identified the associated socio-demographic and clinical factors using logistic regression (LR), random forest (RF), and XGBoost algorithms. We performed threshold optimization for converting predicted probabilities into binary predictions and identified the cut-off maximizing the sum of sensitivity and specificity.ResultsFour thousand six hundred seventy ICU admissions (3,958 patients) were examined. MDRO colonization rate was 17.59% (13.03% VRE, 1.45% CRE, and 7.47% MRSA). Our study achieved the following sensitivity and specificity values with the best performing models, respectively: 80% and 66% for VRE with LR, 73% and 77% for CRE with XGBoost, 76% and 59% for MRSA with RF, and 82% and 83% for MDRO (i.e., VRE or CRE or MRSA) with RF. Further, we identified several predictors of MDRO colonization, including long-term care facility stay, current diagnosis of skin/subcutaneous tissue or infectious/parasitic disease, and recent isolation precaution procedures before ICU admission.ConclusionOur data-driven modeling framework can be used as a clinical decision support tool for timely predictions, characterization and identification of high-risk patients, and selective and timely use of infection control measures in ICUs.
Lifestyle, Physical Activity, Eating and Hygiene Habits: A Comparative Analysis Before and During the COVID-19 Pandemic in Student Population
Authors: Sekulic Marija , Stajic Dalibor , Jurisic Skevin Aleksandra , Kocovic Aleksandar , Zivkovic Zaric Radica , Djonovic Nela , Vasiljevic Dragan , Radmanovic Branimir , Spasic Marko , Janicijevic Katarina , Simic Vukomanovic Ivana , Niciforovic Jovan , Parezanovic Ilic Katarina , Barac Stevan , Lukovic Tanja , Joksimovic Stefan 
Published: March 2022

BackgroundChanging daily habits such as diet, hygiene and physical activity may be some of the consequences of the COVID-19 pandemic. The aim of the study was to analyze the effect of this pandemic on lifestyle, physical activity, eating and hygiene habits among students.MethodsThis cross-sectional study involved 171 students from the Faculty of Medical Sciences, University of Kragujevac, Serbia. Data were statistically analyzed using Wilcoxon Signed-Rank test, Marginal homogeneity test and Chi-square test. The differences were considered statistically significant when p ≤ 0.05.ResultsIn this study, it was observed that the most common physical activity before the pandemic was walking, while during the pandemic was home exercising. Compared to the period before the pandemic, there was no difference in the time spent engaging in daily physical activity (p = 0.334). However, there was a significant increase in sitting time during the pandemic (p = 0.005). Difference was noticed in the use of breakfast, the number of meals, and the type of fat in the diet before and during the pandemic (p = 0.000). During the pandemic, there was an increase in the use of fruits (p = 0.000), vegetables, and nuts (p = 0.001), while the use of fast food and alcohol have decreased. During the COVID-19 pandemic, a significant increase in the use of dietary supplements was observed (40.2%), (p = 0.008).ConclusionsGiven that the COVID-19 pandemic is ongoing, certain changes in lifestyle observed in this study should be confirmed in more extensive population studies.
Individual Surgical Treatment of Stage IV Müller-Weiss Disease According to CT/MRI Examination: A Retrospective Study of 12 Cases
Authors: Liu Wenzhou , Chen Yanbo , Zeng Gang , Yang Tao , Ma Mengjun , Song Weidong 
Published: March 2022

BackgroundThis study reported the individual surgical treatment of 12 cases with stage IV Müller-Weiss disease (MWD) according to CT/MRI examination.MethodsIn total, 12 cases diagnosed with stage IV MWD in our hospital from 2015 to 2019 were included in the retrospective study. Relevant clinical outcomes were evaluated preoperatively and postoperatively.ResultsThe follow-up results showed satisfactory outcomes in all cases. All the cases were presented with tenderness and chronic pain on the midfoot dorsum, and three cases were also presented with tenderness and pain on the lateral side of the midfoot, in which calcaneal cuboid arthritis was revealed by CT/MRI. The American Orthopedic Foot and Ankle Society (AOFAS) scores elevated from 62.5 ± 6.8 (range: 53–74) preoperatively to 95.3 ± 7.2 (range: 73–100) postoperatively (P &lt; 0.005). The Visual Analog Scale (VAS) scores declined from 4.2 ± 0.9 (range: 3–5.5) preoperatively to 0.5 ± 0.3 (range: 0–2) postoperatively (P &lt; 0.001). On the weight-bearing lateral view of the foot, the Tomeno-Méary angle (TM lat) changed from −11.2 ± 4.2 (range: −17.2 to −2.8) degrees preoperatively to −2.4 ± 3.9 (range: −10.2 to 5.2) degrees postoperatively (P &lt; 0.001).ConclusionsThe fusion of the talus-navicular joint and the adjacent affected joint provide good clinical outcomes. The CT/MRI scans are helpful to identify the adjacent joint arthritis and provide indications for individual treatment for Stage IV MWD.
Is Preemptive Kidney Transplantation Associated With Improved Outcomes when Compared to Non-preemptive Kidney Transplantation in Children? A Systematic Review and Meta-Analysis
Authors: Rana Magar Reshma , Knight Simon , Stojanovic Jelena , Marks Stephen D. , Lafranca Jeffrey A. , Turner Samuel , Dor Frank J. M. F. , Pengel Liset H. M. 
Published: March 2022

Main Problem: Preemptive kidney transplantation (PKT) is performed prior to dialysis initiation to avoid dialysis-related morbidity and mortality in children and adolescents. We undertook a systematic review to compare clinical outcomes in PKT versus kidney transplantation after dialysis initiation in paediatric patients.Methods: The bibliographic search identified studies that compared paediatric recipients of a first or subsequent, living or deceased donor PKT versus non-preemptive kidney transplant. Methodological quality was assessed for all studies. Data were pooled using the random-effects model.Results: Twenty-two studies (n = 22,622) were included. PKT reduced the risk of overall graft loss (relative risk (RR) .57, 95% CI: .49–.66) and acute rejection (RR: .81, 95% CI: .75–.88) compared to transplantation after dialysis. Although no significant difference was observed in overall patient mortality, the risk of patient death was found to be significantly lower in PKT patients with living donor transplants (RR: .53, 95% CI: .34–.83). No significant difference was observed in the incidence of delayed graft function.Conclusion: Evidence from observational studies suggests that PKT is associated with a reduction in the risk of acute rejection and graft loss. Efforts should be made to promote and improve rates of PKT in this group of patients (PROSPERO).Systematic Review Registration:https://clinicaltrials.gov/, CRD42014010565
Ecological Contraception: Hormone-Free Contraception
Authors: Занько С.Н. , Дородейко В.Г. , Журавлев А.Ю. 
Published: March 2022

Внутриматочная контрацепция сегодня – это не только популярный, но и динамично развивающийся метод предупреждения нежеланной беременности. Разнообразные средства позволяют индивидуализировать выбор, а их доказанная эффективность наряду с безопасностью и хорошей переносимостью обеспечивают удовлетворенность использованием, а потому высокую приверженность самих женщин этому методу.В статье рассматриваются возможности использования и преимущества некоторых отечественных белорусских разработок «Медицинского предприятия Симург».Только при использовании внутриматочной контрацепции (ВМК) «Юнона» применяется дифференцированный подход и индивидуальный подбор контрацептива, что позволяет избежать большинства вероятных осложнений. В Республике Беларусь и других странах, где применяются ВМК «Юнона», он широко используется.
Intrauterine contraception today is not only a popular but also a dynamically developing method of preventing unwanted pregnancy. Different means allow individualizing the choice, and their proven effectiveness along with safety and good tolerance ensure satisfaction with use and therefore high adherence of women to this method.The article discusses the possibilities of use and advantages of some domestic Belarusian developments of "Medical Enterprise Simurg".Only IUD "Yunona" uses a differentiated approach and individual selection of contraceptive which allows to avoid most of possible complications. IUDs "Yunona" are widely used in the Republic of Belarus and other countries where they are administered.