bluuebunny/crossref_metadata_2025_split huggingface dataset:
Promoción del desarrollo de la comprensión lectora a través de un Ambiente Virtual de Aprendizaje (AVA) en el área de lengua castellana.
Authors: Zapata Arias Sandra Elena 
Published: July 2022

La propuesta de intervención buscaba promover el desarrollo de la comprensión lectora a través de un Ambiente Virtual de Aprendizaje (AVA) en el área de lengua castellana en los estudiantes del grado décimo de la Institución Educativa Alberto Lebrún Múnera del municipio de Bello. Para ello, se partió del diagnóstico de las habilidades que los estudiantes tenían en comprensión lectora y basándose en los resultados, se implementó una unidad didáctica; por último, se evaluó los conocimientos adquiridos. Tomando la metodología Investigación Acción Participativa (IAP), se obtuvieron los datos a partir de ejercicios de comprensión lectora y la evaluación.
Se puede afirmar, que en la actualidad el rol docente se debe ubicar en la comprensión de las nuevas formas de enseñar y aprender en un mundo digital y globalizado, y que la incorporación de propuestas que sean llamativas para los estudiantes, como el uso de la plataforma Edmodo, se convierte en una herramienta metodológica de alto impacto para el área de lengua castellana. Con este proyecto se logró fortalecer los diferentes niveles de lectura y de pensamiento de la comprensión lectora, por medio de diversas herramientas que estimularon en los estudiantes el interés y la motivación por aprender.
Evaluation of Beta-2 Integrin and Platelets Roles in Sickle Cell Disease Pathogenicity in Basrah Governorate Patients
Authors: Al-Mishrey Maha K. 
Published: July 2022

Sickle cell disease (SCD) comprises an inherited blood disorder that is life long and affects many people globally. In spite of the development in treatment, SCA is a considerable cause of mortality and morbidity. The present study tries to assess the role of leukocytes represented by β integrin(CD18) and platelets and their productivity in the pathogenicity of disease during the steady state and crisis in comparison with the healthy as-control group, SCD patients (15) enrolled during crisis and steady state (follow up) showed a significant increase in leukocytes and platelets cells productivity during crisis when compared to the steady state and in the steady state when compared to the healthy control group . In this study, SCD pathophysiology in steady state and crisis affected by the platelets account and leukocyte activation triggered by inflammatory factors and reflex on the adherence and attachment between cells and blood vessel led to vascular occlusion (VOC).
Gold nanoparticles’ concentration dependent reactivity to alendronate, memantine, andtobramycin
Authors: Eissa Dina M. , Mabrouk Mokhtar M. , Ebeid El Zeiny M. , Hamid Mohamed A. Abdel 
Published: July 2022

Abstract
Turkevich gold nanoparticles are the original nanoparticles that have been modified over time. Its combination with targeting medications such as alendronate, memantine, and tobramycin will provide additional benefits intargeting specific areas in the bone, brain, and microorganisms, respectively.Hence, The reactivity and stability of nanoparticles with various drugconcentrations (milli-,micro-, and nano-levels) have been studied. Withalendronate, the absorbance spectra of nanoparticles at λmax 520 nm werealways stable and no redshifts occurred. In contrast, the spectra with memantineand tobramycin were stable at the nano-level and redshifts occurred at the milli-& micro- levels. HRTEM and DLS revealed that the core diameter was relativelystable in all cases, whereas the hydrodynamic diameter & zeta potential variedwith varying drug concentrations. Increasing concentration increasedhydrodynamic diameter slightly with memantine (from 64.99 to 98.41 nm),dramatically with tobramycin (from 135.3 to 332.16 nm), and almost negligiblywith alendronate (from 52.08 to 58.94 nm ). Zeta Potential, conversely, isreduced as concentration increases. Memantine had the greatest reduction innegativity, followed by tobramycin, but alendronate had a slight increase innegativity. Benefits from this research would be in targeted drug delivery, wherestability and reactivity of gold nanoparticles are critical.
PRevention of COVID-19 with Oral Vitamin D supplemental Therapy in Essential healthCare Teams (PROTECT): Ancillary study of a randomised controlled trial
Authors: Hosseini Banafsheh , Tremblay Cecile L , Longo Cristina , Golchi Shirin , White John , Quach Caroline , Ste-Marie Louis-Georges , Platt Robert , Ducharme Francine 
Published: July 2022

Abstract
Background
The study objectives were to ascertain the efficacy of vitamin D supplementation in rapidly increasing serum vitamin D and of implementation of a hybrid (virtual and in-person) trial.
Methods
In a randomised triple-blind controlled trial, healthcare workers were allocated to receive an oral bolus of 100,000 IU with 10,000 IU/week vitamin D3 or placebo. The co-primary outcomes of this ancillary study were the change from baseline in serum 25-hydroxyvitamin D [(Δ) 25(OH)D] and proportion with vitamin D sufficiency (25(OH)D ≥ 75nmol/L), at endpoint. Adherence to supplements and procedures as well as adverse event rates were documented.
Results
Thirty-four (19 intervention, 15 control) subjects were randomised, with 28 (41%) virtual visits. After 44.78 ± 11.00 days from baseline, a significant adjusted group difference of 44.2 (34.7, 53.8) nmol/L was observed in the Δ 25(OH)D (95%CI) in favor of supplementation; 77.8% of intervention, and 13.3% of control, patients were vitamin D sufficient (OR:6.11, 95%CI:1.6, 22.9). The adherence to intervention was 94.7% in the intervention and 100% in the control groups. Irrespective of visit type, high adherence was observed in sampling procedures and completion of fortnightly online questionnaire. No adverse events attributable to vitamin D were reported.
Conclusion
The vitamin D supplementation rapidly and safely raised 25(OH)D levels to sufficient levels for a biological effect. Similarly high adherence to study procedures was observed with virtual and in-person participation.
Trial registration:
This trial was registered at https://clinicaltrials.gov on July 23, 2020 (#NCT04483635)
Dual-objective modelling and optimization for a low-carbon waste classified collection problem
Authors: Lu Xulong , Pu Xujin , Wang Hongfeng , Fu Yaping 
Published: July 2022

Abstract
Recently, waste collection has become a research hotspot and an urgent problem to be solved due to the explosive growth of waste. With the improvement of the quality of life, there are various kinds of waste, which has caused great difficulties for waste collection. As a result, waste classified collection is proposed worldwide. However, the existing research on waste collection pays little attention to waste classification, and most of them aim to minimize the cost without consideration of it. In this paper, we consider the pretreatment and classification of waste transfer stations. In recent years, global warming caused by carbon emission has already become a serious problem. Therefore, this work proposes a dual-objective multi-depot two-echelon green vehicle routing problem with various pickups to optimize waste classified collection for the first time, and then we establish a mixed-integer programming model. To solve our investigated model effectively, we design a multi-objective brain storm optimization algorithm where a novel clustering strategy based on rank method and differential mutation are used. Compared with two classical multi-objective optimization algorithms on some generated test instances and a real-world case, the experimental results show that the proposed model helps sanitation departments improve economic and environmental benefits of waste classified collection, and the proposed algorithm is an excellent optimizer to solve the concerned problem
The correlation analysis between childhood behavioral disturbance and maternal alexithymia: an observational study
Authors: Lin Yu-Chen , Lee Wei-Yang 
Published: July 2022

Abstract
Background
From the perspective of children's psychological development and psychoanalysis, the primary caregiver's response to children's behavior has a considerable impact on children's emotional and behavioral development. If caregivers lack the ability to empathize, difficulties in detecting and responding to children's emotions, which may lead to children's emotional and behavioral disorders. The purpose of this study is to preliminarily explore the correlation between children's behavioral and emotional disorders and the mother's inability to express emotions.
Method
We collected a total of 78 cases from outpatient clinics, aged between 3–13 years old. The Taiwan version of the " Toronto Alexithymia Scale" and "Children's Behavior Checklist" questionnaires were used as research tools, which were filled out by the mothers themselves. We use Spearman correlation tool for follow-up analysis.
Results
The factor 1, 2 and 3 of TAS are positively correlated with somatic complaint subscale of CBCL. (F2: p < 0.01; F1 and F3:P < 0.05); The factor 1 of TAS is positively correlated with internal subscale of CBCL(p < 0.05) and withdrawn subscale of CBCL(p < 0.05). We found significant associations TAS-Total and the SC subscale of CBCL (p < 0.05), and factor 1 of TAS and WD of CBCL on boy alone (p < 0.05). However, negative related association was noted between TAS-F3 and the SP subscale of CBCL (p < 0.05).
Conclusion
We infer that when mothers are less able to distinguish internal emotional feelings, children's emotions and behaviors tend to be internalized, and they are more likely to show withdrawal, complaints of physical discomfort, and depression and anxiety. In addition, boys tend to show withdrawal traits in the internalization dimension; girls tend to show depression and anxiety in that respectively. This study preliminarily shows that there is a partial correlation between mother’s alexithymia and children's emotional and behavioral disorders, and it is worth further exploring the impact of caregivers' emotional traits on children's growth in the future.
Federated Learning Algorithms for Generalized Mixed-effects Model (GLMM) on Horizontally Partitioned Data from Distributed Sources
Authors: Li Wentao , Tong Jiayi , Anjum Md. Monowar , Mohammed Noman , Chen Yong , Jiang Xiaoqian 
Published: July 2022

Abstract
Objectives: This paper developed federated solutions based on two approximation algorithms to achieve federated generalized linear mixed effect models (GLMM). The paper also proposed a solution for numerical errors and singularity issues. And compared the developed model’s outcomes with each other, as well as that from the standard R package (‘lme4’). Methods: The log-likelihood function of GLMM is approximated by two numerical methods (Laplace approximation and Gaussian Hermite approximation), which supports federated decomposition of GLMM to bring computation to data. To solve the numerical errors and singularity issues, the loss-less estimation of log-sum-exponential trick and the adaptive regularization strategy was used to tackle the problems caused by federated settings. Results: Our proposed method can handle GLMM to accommodate hierarchical data with multiple non-independent levels of observations in a federated setting. The experiment results demonstrate comparable (Laplace) and superior (Gaussian-Hermite) performances with simulated and real-world data. Conclusion: We modified and compared federated GLMMs with different approximations, which can support researchers in analyzing versatile biomedical data to accommodate mixed effects and address non-independence due to hierarchical structures (i.e., institutes, region, country, etc.).
Evaluation of a smartphone-based visual body composition application with artificial intelligence trained by 4-compartment model
Authors: Graybeal Austin , Brandner Caleb , Tinsley Grant 
Published: July 2022

Abstract
The aim of this study was to assess the precision and agreement of a visual body composition (VBC) application using a 4-compartment (4C) model criterion. Body composition estimations were collected from 102 participants using methods required for a 4C model and a VBC application using two different smartphone types. Intraclass correlation coefficients (0.96–0.99) and root mean square coefficients of variation (0.5%-3.0%) showed good reliability for body fat %, fat mass (FM), and fat-free mass (FFM) between and within smartphone types. There were no significant mean differences between 4C model estimates and the VBC estimates for the total sample, by sex, and for white and Black/African-American participants. VBC estimates demonstrated equivalence with the 4C model for all variables, but revealed proportional biases that underestimated BF% and FM at higher degrees of each variable. VBC applications trained by a 4C model are reliable and produce body composition estimates equivalent with a 4C.
Risk Factors of the Retention of Deciduous Teeth in Adolescents Aged 12–15: A Cross-sectional Study
Authors: Liu Junyu , Shi Xiaotong , Hou Ruxia , Liu Jiajia , Yang Tingting , Li Ran , Zhao Bin , Feng Guoqing , Li Junming , Wang Xiangyu 
Published: July 2022

Abstract
Background:
Retention of deciduous teeth (RDT) is a tooth replacement abnormality that affects the oral cavity and health of adolescents. However, evidence of the quantitative effects of determinants on RDT is still limited. A better understanding of the quantifying determinants of RDT would support evidence-based policymaking to reduce the incidence of RDT in China and other developing areas globally.
Methods:
The target population of this study focuses on the 12- to 15-year-old age group amounting to 11,351 sample individuals derived from the Fourth National Oral Health Survey of China (2015) and the First Oral Health Survey of Shanxi Province, China (2018). Propensity score matching(PSM) method and logical regression model were employed to explore the epidemiological characteristics and determinants of RDT in adolescents.
Results:
The retention rate of deciduous teeth (RRDT) of adolescents aged 12–15 in Shanxi Province was 11.74% (95% confidence interval [CI]: 9.78–13.70%). Dental caries was found to be a risk factor, with a corresponding odds ratio (OR) of 1.22 (95%CI: 1.04–1.43). Relative to a non-only child, the OR of an only-child was 0.72 (95%CI: 0.60–0.86). For adolescents, brushing their teeth every day and having their teeth examined can lower their risk of RDT. The education level of the mother and body mass index were found to be protective factors of RDT.
Conclusions:
Socio-economic factors and individual characteristic behaviours are closely related to the RDT of adolescents aged 12–15 years. More attention should be paid to the RDT of adolescents in China and other areas worldwide.
Municipal Wastewater Treatment uses Vertical flow followed by horizontal flow in a two-stage hybrid constructed wetland planted with Calibanus hookeri and Canna indica (Cannaceae)
Authors: Singh Krishna Kumar , Vaishya Rakesh Chandra 
Published: July 2022

Abstract
The utilization of hybrid constructed wetland systems has recently expanded due to more rigorous municipal wastewater discharge and also complex wastewaters treated in hybrid constructed wetlands (HCWs). A lab-scale two-stage Experimental setup of Vertical flow followed by horizontal flow hybrid constructed wetland (VFHCW- HFHCW) configuration was built. First stage vertical flow hybrid constructed wetland reactor with the surface area was 1963.49 cm2 and second stage horizontal flow hybrid constructed wetland reactor with the surface area was 2025 cm2. The HCW unit was planted with two type plants: Calibanus hookeri and Canna indica (Cannaceae). Influent Municipal wastewater flow rate 112.32 lit./day, hydraulic loading rate (HLR) 0.55 meter/day, and hydraulic retention time One day. The efficiency was evaluated in municipal wastewater quality improvement and Physico-chemical analysis in our laboratory. The removal rate after the second stage horizontal flow of BOD3 at 27oC, COD, TSS, TP, NH3-N, and NO3-N reached 92.75%, 89.90%, 85.45%, 88.83%, 99.09%, and 96.05%, respectively. The results shown after both stage hybrid constructed wetland VFHCW- HFHCW, treated effluent of Municipal wastewater produced high-quality effluent which may be reused in gardening, agriculture, and flushing in toilet purpose according to Bureau of Indian Standards (BIS) code for practices. However, in the future, hybrid constructed wetlands could be standards design criteria developing and enhancing the performance standards and economic meets both to make more popular technology of the hybrid constructed wetland (HCW).
Targeted deletion of ecto-5′-nucleotidase results in retention of inosine monophosphate content in postmortem muscle of medaka (Oryzias latipes)
Authors: Murakami Yu , Ando Masashi , Futamata Ryota , Horibe Tomohisa , Ueda Kazumitsu , Kinoshita Masato , Kobayashi Toru 
Published: July 2022

Abstract
Inosine monophosphate (IMP) is an important indicator of meat freshness and contributes to its umami taste. An attractive strategy for enhancing umami is to suppress the IMP-degrading activity and increase the IMP content in the skeletal muscle through genome editing technology using the CRISPR-Cas9 system. However, the molecular mechanisms underlying IMP degradation remain unclear. We cloned two ecto-5’-nucleotidase genes, designated as ecto-5′-nucleotidase-a (nt5ea) and ecto-5′-nucleotidase-b (nt5eb), from medaka (Oryzias latipes), a vertebrate model organism. Expression analysis using embryos showed that nt5ea or nt5eb overexpression remarkably upregulated IMP degradation, and that the IMP degrading activity was higher in Nt5ea than in Nt5eb. Furthermore, we established frame-shifted or large deletion (lacking nt5ea or nt5eb locus) mutant strains and assayed the effects of gene disruptions on the amount of IMP in skeletal muscle. The nt5ea-deficient medaka showed significantly higher levels of IMP at 48 h postmortem than did the wild-type fish. The nt5eb mutants also exhibited higher IMP contents compared to the wild types, but the increase was less than that in the nt5ea mutants. Our results demonstrated that nt5e is an important regulator of IMP levels in skeletal muscle and that its loss of function was effective in maintaining IMP content.
Discovery of common loci and candidate genes for controlling salt-alkali tolerance and yield-related traits in Brassica napus L.
Authors: Zhang Yan , Zhang Qi , Wang Han , Tao Shunxian , Cao Hanming , Shi Yiji , Bakirov Aldiyar , Xu Aixia , Huang Zhen 
Published: July 2022

Abstract
Rapeseed (Brassica napus L.) is one of the most important oil crops in the world. Its yield is decided by multiple yield-related traits, which is also susceptible to environmental factors. Many yield-related quantitative trait loci (QTLs) have been reported in Brassica napus; however, no studies have been conducted to investigate both salt-alkali tolerance and yield-related traits simultaneously. Here, specific-locus amplified fragment sequencing (SLAF-seq) technologies were utilized to map the QTLs for salt-alkali tolerance and yield-related traits. A total of 65 QTLs were identified, including 30 QTLs for salt-alkali tolerance traits and 35 QTLs for yield-related traits, accounting for 7.61–27.84% of the total phenotypic variations. Among these QTLs, 18 unique QTLs controlling two to four traits were identified by meta-analysis. Six novel and unique QTLs were detected for salt-alkali tolerance traits. By comparing these unique QTLs for salt-alkali tolerance traits with those previously reported QTLs for yield-related traits, seven co-localized chromosomal regions were identified on A09 and A10. Combining QTL mapping with transcriptome of two parents under salt and alkaline stresses, thirteen genes were identified as the candidates controlling both salt-alkali tolerance and yield. These findings provide useful information for future breeding of high-yield cultivars resistant to alkaline and salt stresses.
Elements That Impact on Participants’ Psychological Suffering in Simplified Fire Drills
Authors: Zhao Longlong , Su Peng 
Published: July 2022

Abstract
Necessary fire drills can effectively prevent or reduce fire hazards on the one hand, and on the other hand, they may also bring a certain amount of psychological suffering to participants. In order to identify elements influencing participants' psychological suffering, this study distributed a specially designed questionnaire to postgraduate students who had experienced fire drills in London. The questionnaires were designed on the awareness of precaution, the level of participation, the rank of satisfaction, the number of fire drills experienced, procedural arrangements, and the participants' general evaluation, and this research assessed their impact on participants' psychological suffering with the help of multiple regression. An analysis of the 656 questionnaires shows that the awareness of precaution, the level of participation, the rank of satisfaction, the number of fire drills experienced, procedural arrangements, and the participants' general evaluation all significantly impacted participants' psychological suffering. Based on these, we offered four recommendations that could efficiently decrease participants' psychological suffering. They are gradually improving participants' awareness of precaution, increasing the degree of components' engagement in fire drills, redesigning the procedural arrangement of simplified fire drills timely, and limiting the frequency of fire drills appropriately.
Co-immunization with pre-erythrocytic antigens alongside circumsporozoite protein can enhance sterile protection against Plasmodium sporozoite infection.
Authors: Sather Noah , Vigdorovich Vladimir , Patel Hardik , Watson Alexander , Raappana Andrew , Reynolds Laura , Selman William , Beeman Suzannah , Edlefsen Paul , Kappe Stefan 
Published: July 2022

Abstract
Malaria-causing Plasmodium parasites have a complex life cycle and present numerous antigen targets that may contribute to protective immune responses. The currently recommended vaccine—RTS,S—functions by targeting the P. falciparum circumsporozoite protein (CSP), which is the most abundant surface protein of the sporozoite form responsible for initiating infection of the human host. Despite showing only moderate efficacy, RTS,S has established a strong foundation for the development of next-generation subunit vaccines. Our previous work characterizing the sporozoite surface proteome identified additional non-CSP antigens that may be useful as immunogens individually or in combination with CSP. In this study, we examined eight such antigens using the rodent malaria parasite P. yoelii as a model system. We demonstrate that despite conferring weak protection individually, co-immunizing each of several of these antigens alongside CSP, could significantly enhance the sterile protection achieved by CSP immunization alone. Thus, our work provides compelling evidence that a multi-antigen pre-erythrocytic vaccine approach may enhance protection compared to CSP-only vaccines. This lays the groundwork for further studies aimed at testing the identified antigen combinations in human vaccination trials that assess efficacy with controlled human malaria infection.