bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of sarcopenia on outcomes of patients undergoing liver resection for hepatocellular carcinoma
Authors: Yang Jinhuan , Chen Kaiwen , Zheng Chongming , Chen Kaiyu , Lin Jian , Meng Qishan , Chen Ziyan , Deng Liming , Yu Haitao , Deng Tuo , Bo Zhiyuan , He Qikuan , Wang Yi , Chen Gang 
Published: July 2022

AbstractBackgroundPrevious studies have indicated that sarcopenia is associated with poor post‐operative outcomes in liver cancer patients, but the studies are limited by confounding from mixed diseases, retrospective data, and non‐standardized measurement methods. At present, there is no research with both muscle mass and strength as predictors for hepatocellular carcinoma (HCC) outcomes. We studied the impact of sarcopenia on post‐operative outcomes in HCC patients in a cohort study designed according to the European Working Group on Sarcopenia in Older People standards.MethodsA total of 781 consecutive patients admitted to our centre were registered from May 2020 to August 2021. All participants submitted questionnaires and underwent handgrip strength, chair stand test, physical performance, and computed tomographic evaluation. Then, they were divided into three groups according to muscle mass and strength: Group A (reduced muscle mass and strength), Group B (reduced muscle strength or reduced muscle mass), and Group C (normal muscle mass and strength). The baseline data and post‐operative outcomes were compared and analysed. The primary outcome variable in this study was the presence of a major post‐operative complication, and the secondary outcome was the 90‐day re‐admission rate.ResultsA total of 155 patients [median age, 60.00 (IQR, 51.00–66.00) years; 20 females (12.90%)] were included after strict exclusion. The mean (SD) BMI was 23.37 ± 0.23 kg/m2. The mean (SD) SMI of all participants was 47.05 ± 0.79 cm2/m2, and the mean (SD) handgrip strength was 32.84 ± 0.69 kg. Among them, 77 (49.68%) patients underwent laparoscopic hepatectomy, and 73 (47.10%) patients received major hepatectomy. Regarding the post‐operative results, Group A had a higher rate of major complications [40.91% (9 of 22) vs. 11.94% (8 of 67) in Group B and 6.06 (4 of 66) in Group C; P = 0.001], higher rate of blood transfusion (77.27% vs. 46.27% in Group B and 42.42% in Group C; P = 0.015), higher hospitalization expenses (P = 0.001), and longer hospital stay (P < 0.001). There was no difference in 90‐day re‐admission rates among the three groups. Sarcopenia (hazard ratio, 10.735; 95% CI, 2.547–45.244; P = 0.001) and open surgery (hazard ratio, 4.528; 95% CI, 1.425–14.387; P = 0.010) were independent risk factors associated with major complications.ConclusionsSarcopenia is associated with adverse outcomes after liver resection for HCC. It should be evaluated upon admission to classify high‐risk patients and reduce the risk of major complications.
Identification and clinical significance of nodular regenerative hyperplasia in primary sclerosing cholangitis
Authors: Ozturk Nazli Begum , Fiel Maria Isabel , Schiano Thomas D. 
Published: July 2022

AbstractBackground and AimPrimary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease characterized by inflammation and fibrosis of intrahepatic and extrahepatic bile ducts. PSC is frequently associated with inflammatory bowel disease (IBD). Nodular regenerative hyperplasia (NRH) can occur in IBD with the use or even in the absence of thiopurine treatment. We aimed to study the significance of the presence of NRH and obliterative portal venopathy (OPV), both causes of non‐cirrhotic portal hypertension (NCPH), in patients having PSC.MethodsPatients with PSC and concurrent NRH on liver biopsy were identified from the digital pathology database covering the period 2003–2019. Evaluation of liver biopsy and the original diagnoses were confirmed on review based on standard histological features diagnostic for NRH and OPV. Clinical and laboratory data were obtained from electronic medical records.ResultsThirty‐one patients (21 male, 10 female; median age at biopsy 40.1 years) were included in the study. Twelve (38.7%) patients had OPV in addition to NRH on the liver biopsy. Nineteen (61.2%) patients had IBD including 11 with Crohn's disease (CD), 7 with ulcerative colitis (UC), and 1 with indeterminate colitis. Thirteen (41.9%) patients had evidence of portal hypertension, 10 (32.2%) with esophageal varices, 4 (12.9%) with history of variceal bleeding, 6 (19.3%) with ascites, and 14 (12.9%) with splenomegaly. Eleven (35.4%) patients had a cirrhotic‐appearing liver on imaging. Twelve (38.7%) patients had a history of prior or current thiopurine use.ConclusionsThe current study suggests that NRH with or without OPV independently occurs in patients having PSC and may lead to NCPH, even in the absence of concurrent IBD and/or thiopurine therapy.
HPV‐CCDC106 integration promotes cervical cancer progression by facilitating the high expression of CCDC106 after HPV E6 splicing
Authors: Zhi Wenhua , Wei Ye , Lazare Cordelle , Meng Yifan , Wu Ping , Gao Peipei , Lin Shitong , Peng Ting , Chu Tian , Liu Binghan , Ding Wencheng , Cao Canhui , Wu Peng 
Published: July 2022

AbstractHuman papillomavirus (HPV) integration and high expression of HPV oncogenes (E6 and E7) are important mechanisms for HPV carcinogenesis in cervical cancer. However, the relationship between HPV integration and HPV E6 spliced transcripts, as well as the underlying mechanisms of HPV integration in carcinogenesis after HPV E6 splicing remains unclear. We analyzed HPV‐coiled‐coil domain containing 106 (CCDC106) integration samples to characterize the roles of HPV integration, E6 spliceosome I (E6*I), and high CCDC106 expression in cervical carcinogenesis. We found that E6 was alternatively spliced into the E6*I transcript in HPV‐CCDC016 integration samples with low p53 expression, in contrast to the role of E6*I in preventing p53 degradation in cervical cancer cells. In addition, CCDC106 was highly expressed after HPV‐CCDC106 integration, and interacted with p53, resulting in p53 degradation and cervical cancer cell progression in vitro and in vivo. Importantly, when E6*I was highly expressed in cervical cancer cells, overexpression of CCDC106 independently degraded p53 and promoted cervical cancer cell progression. In this study, we explored the underlying mechanisms of HPV‐CCDC106 integration in HPV carcinogenesis after HPV E6 splicing, which should provide insight into host genome dysregulation in cervical carcinogenesis.
Safety and efficacy of molnupiravir in SARS‐CoV‐2‐infected patients: A real‐life experience
Authors: De Vito Andrea , Colpani Agnese , Bitti Alessandra , Zauli Beatrice , Meloni Maria Chiara , Fois Marco , Denti Lucia , Bacciu Sara , Marcia Claudia , Maida Ivana , Babudieri Sergio , Madeddu Giordano 
Published: July 2022

AbstractSince the start of the severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2) pandemic, several treatments have been proposed to cure coronavirus disease 2019 (COVID‐19) and prevent it. Molnupiravir is a ribonucleoside prodrug of N‐hydroxycytidine with an in vitro and in vivo activity against SARS‐CoV‐2. We conducted a retrospective cohort study that included all people treated with molnupiravir between January 10, 2022, and March 31, 2022, at the University Hospital of Sassari. Molnupiravir was prescribed, according to the Italian Agency of Drug indications, to patients with recent symptom onset (≤5 days), no need for oxygen supplementation, and with a high risk of disease progression for the presence of chronic diseases. We included 192 people with a mean age of 70.4 ± 15.4 years, with 144 (75%) patients over 60 years. During the follow‐up, 20 (10.4%) patients showed a disease progression. At the multivariate analysis, older age, having neurological disease, having dyspnea at the onset of the symptoms, and acquiring SARS‐CoV‐2 infection during hospital admission were associated with an increased risk of progression. In contrast, an early start of treatment was associated with a reduced risk of disease progression. Molnupiravir was also extremely safe since 13 (6.8%) adverse events were reported, with only one interruption. Our study shows that monlupiravir confirmed its efficacy and safety in a real‐life cohort that included a high percentage of elderly people with a high comorbidity burden.
Impact of reduced ENSO variability and amplitude on ISMR prediction in the long‐lead forecasts of monsoon mission CFS
Authors: Pillai Prasanth A. , Rao Suryachandra A. , V. Gangadharan Kiran , Pradhan Maheswar , Srivastava Ankur , Jain Deepesh K. 
Published: July 2022

AbstractDespite the reduction in interannual variability and amplitude of El Nino Southern Oscillation (ENSO) after 2000, its influence on Indian summer monsoon rainfall (ISMR) is stronger than in the previous decades. Meanwhile, our analysis with high‐resolution Monsoon Mission Climate Forecast system (MMCFS, ~38 km horizontal resolution) indicates a sharp decrease in ISMR skill and ENSO–ISMR teleconnection since 2000 at long lead (3 months, Feb IC) hindcasts. At the same time, ISMR skill is intensified for a short lead (1 month, Apr IC). The persistence skill of ENSO decreased after 2000, but the decrease is more severe for January–March initial months. So the ENSO skill will be lower for models initialized during these months compared with other months. Also, the Feb IC hindcast has a similar ENSO teleconnection pattern during both periods and hence it failed to capture the modified influence of ENSO after 2000, such as the absence of dipole anomalies in the Indian Ocean and stronger subsidence over India. Thus, the model hindcasts that depend heavily on ENSO teleconnection for ISMR simulation have reduced skill in recent years. The role of other predictors along with ENSO for Apr IC hindcasts is hence evident in the current period. It is shown that after 2000, tropical Atlantic SST anomalies contributed significantly to ISMR interannual variability in observations. In these, Atlantic Meriodnal Mode (AMM) influences ISMR through off‐ equatorial circulation in absence of ENSO during the second period. Atlantic zonal mode has a weaker influence in absence of ENSO during both periods. Atlantic SST influence on ISMR is captured by April IC hindcasts during period 2, while Feb IC has the opposite relationship. Thus, the presence of another predictor in the form of tropical Atlantic SST along with strong ENSO–ISMR teleconnection makes the short lead hindcast of ISMR more skilful in the recent period for MMCFS.
Understanding passengers’ satisfaction and loyalty towards ridesharing services
Authors: Shamsudin Mohd Farid , Abu Bakar Abdul Rahim , Hashim Fariza 
Published: July 2022

AbstractThis study examines the ridesharing services in a developing economy, with the aim of revealing the factors influencing passengers’ satisfaction and loyalty. This study is important as the ridesharing industry is growing at a tremendous rate and will ultimately attract many new players in the market. Offered abundant choices, consumers are exploring the best ridesharing services that meet their satisfaction. As the switching costs and brand loyalty are lower for on‐demand services, it is pertinent to understand ridesharing passengers’ satisfaction and loyalty. The findings of this study are based on a questionnaire survey of 200 ridesharing passengers. The results reveal that both brand image and price significantly influence customer satisfaction. However, in terms of customer loyalty, only brand image is statistically significant. Price did not have a significant impact on customer loyalty. Overall, this research corroborated previous studies on the positive relationship of customer satisfaction and customer loyalty. The paper concludes by providing numerous theoretical and practical implications based on the findings of the study
Multi‐proxy reconstruction of the Holocene vegetation and land use dynamics in the Julian Alps, north‐west Slovenia
Authors: Caf Nina , Sabatier Pierre , Šmuc Andrej , Ogrinc Nives , Dolenec Matej , Rapuc William , Potočnik Doris , von Grafenstein Ulrich , Andrič Maja 
Published: July 2022

AbstractSmall mountain lakes are natural archives for understanding long‐term natural and anthropogenic impact on the environment. This study focused on long‐term (last ca. 13 000 years) vegetation changes and sedimentary processes in the catchment area of Lake Planina pri jezeru (1430 m a.s.l.) by using mineralogical, geochemical and palynological methods. Palynological results suggest that regional vegetation between 12 900 and 11 700 cal a bp was a herbaceous–forest tundra (Pinus, Artemisia, Poaceae). Climate warming at the beginning of the Holocene (ca. 11 700 cal a bp) caused the transition from a wetland (Cyperaceae) to an eutrophic lake with alternating anoxic (pyrite) and oxic conditions (gypsum). In addition, the surrounding area became forested (Picea, Larix, Ulmus). Fagus expanded at 10 200 cal a bp and Abies at 8200 cal a bp. Between 7500 and 4300 cal a bp, human impact on the environment was barely noticeable and mostly limited to grazing. During 4300–430 cal a bp human impact became more evident and gradually increased. The greatest influence was observed from 430 cal a bp onwards, when excessive exploitation of the surrounding area (logging and grazing) severely eutrophicated the lake.
Hepatic arterial infusion oxaliplatin plus raltitrexed and chemoembolization in hepatocellular carcinoma with portal vein invasion: A propensity score‐matching cohort study
Authors: Chen Shiguang , Yuan Bo , Yu Wenchang , Wang Xiaolong , He Chengjian , Chen Chuanben 
Published: July 2022

AbstractBackgroundAbout 55% of hepatocellular carcinoma (HCC) cases in China are advanced HCC at the initial diagnosis. We aimed to evaluate the efficacy and safety of hepatic arterial infusion chemotherapy (HAIC) for HCC with portal vein tumor thrombosis (PVTT) compared to transcatheter arterial chemoembolization (TACE) after propensity score matching (PSM).MethodsA propensity score‐matched cohort study was performed in patients with advanced HCC with PVTT who underwent either HAIC using oxaliplatin plus raltitrexed or TACE at three institutions between January 2016 and January 2021. Overall survival (OS), progression‐free survival (PFS), objective response rate (ORR), and adverse events were compared between the groups.ResultsAfter PSM, 44 pairs of patients were assessed. The HAIC group had longer OS (11.2 [95% confidence interval [CI]: 9.9–12.5] vs. 9.0 [95% CI: 5.3–12.7] months; p = 0.010), better PFS (5.6 [95% CI: 3.7–7.9] vs. 2.0 [95% CI: 1.3–2.7] months; p = 0.006), and a higher ORR (Response Evaluation Criteria in Solid Tumors [version 1.1]: 56.8% vs. 18.2%; p < 0.001) than the TACE group. In multivariate analysis, HAIC was identified as an independent favorable prognostic factor for survival.ConclusionsCompared to TACE, HAIC significantly increased the ORR of HCC with portal invasion and prolonged survival without causing a significant increase in severe adverse events.
Effect of topographic variations and tillage methods on gully erosion in the black soil region: A case‐study from Northeast China
Authors: Tang Jie , Liu Gang , Xie Yun , Wu Yongqiu , Wang Daan , Gao Yan , Meng Lingqin 
Published: July 2022

AbstractGully erosion is considered to be a severe land degradation process around the world. The combined effects of tillage methods and topographic variation on gully erosion are poorly understood. This study investigated permanent gullies in three farmland, geomorphic areas in the black soil region of Northeastern China: low mountains and hills, tableland, and rolling hill areas. Cross‐sectional measurements were used to obtain estimates of volumetric soil loss from the gullies. Digital contour maps and remote sensing images were used to obtain the topography and row direction data. The results showed that tableland area had the greatest volumetric soil loss and was the most prone to develop gully erosion, followed by the low mountains and hills, and finally the rolling hill areas. Topography was the dominant control on gully erosion and volumetric soil loss and length density increased first and then decreased as a function of increase of slope gradient. Farmland with slope gradient between 15° and 20° had the most serious gully erosion. Hillslope gullies were classified into three types by morphological indicators. Compared to other geomorphic areas, low mountains and hills had the most gully types and the greatest variability of morphology. Surface areas and volumes were related to gully type. Different tillage methods have affected the frequency of gully occurrence. Cross‐slope tillage areas were more prone to develop gully erosion than contoured tillage and up and down slope tillage areas, especially for farmlands with slope of 5 to 10°. The results suggest that gully erosion could be reduced if up and down slope tillage was used for slope gradients less than 15° and contoured tillage was used for slope gradient greater than 15°. This study demonstrates the combined effect of topographic variations and tillage methods on gully erosion, and highlights the importance of considering different tillage methods under different geographical conditions to control gully erosion.
Acute exacerbations of chronic rhinosinusitis: The current state of knowledge
Authors: Walters Zoe A. , Sedaghat Ahmad R. , Phillips Katie M. 
Published: July 2022

AbstractObjectivesAcute exacerbations of chronic rhinosinusitis (AECRS) are distinct from baseline symptomatology related to chronic rhinosinusitis (CRS). In this review, we seek to examine the literature on AECRS to synthesize the definition, epidemiology, pathophysiology, treatment, and impact of AECRS on CRS patients.MethodsA comprehensive narrative review of the scientific literature, identified by searching PubMed from inception through April 2022, was performed.ResultsAECRS is defined in consensus guidelines as a worsening of chronic sinus disease symptomatology, with a return to baseline, typically after intervention with systemic antibiotics and/or corticosteroids. The working definition used across the literature, however, is broad and heterogeneous. The pathophysiology of AECRS is incompletely understood but is hypothesized to include an interplay of environmental and patient‐specific factors. AECRS have been found to have a negative impact on quality‐of‐life measures, independent of baseline CRS symptomatology, and impact how patients and physicians view overall disease control. Treatment for AECRS includes oral antibiotics and systemic corticosteroids, although their efficacy for AECRS is unclear. Appropriate use of medical and surgical treatment for CRS can reduce the frequency of AECRS.ConclusionsAECRS are a distinct entity in CRS patients and should be independently assessed when evaluating patients for CRS control. The efficacy of systemic medication usage for AECRS is currently unclear, but appropriate medical management of baseline CRS can reduce the frequency of AECRS. More research is needed to further understand this phenomenon, including a more precise and prospective definition, defined epidemiology, and how to appropriately treat.Level of Evidence5
Predicting larval alewife transport in Lake Michigan using hydrodynamic and Lagrangian particle dispersion models
Authors: Rowe Mark D. , Prendergast Sara E. , Alofs Karen M. , Bunnell David B. , Rutherford Edward S. , Anderson Eric J. 
Published: July 2022

AbstractSeveral species of fish in large lakes and marine environments have a pelagic larval stage, and are subject to variable transport that can ultimately regulate survival and recruitment success. Alewife, Alosa pseudoharengus, are subject to transport by complex coastal currents during their pelagic larval stage (~ 30 d). We assessed backward‐trajectory simulations, consisting of a Lagrangian particle dispersion model linked to the Finite Volume Community Ocean Model, to estimate likely hatch locations of aged larval alewife collected from locations on both the eastern and western sides of Lake Michigan during July 2015. We used four deployments of three satellite‐tracked drifter buoys in coastal waters to assess model skill in estimating the origin of a drifter from its final location. We found that the trajectories of drifters varied greatly, depending on wind events and associated coastal transport processes, including upwelling/downwelling and coastal jet currents. In 2 of 12 cases, the backward trajectory simulations failed to predict the drifter origin, associated with transport of 170 km in a narrow coastal jet current. In the remaining 10 cases, the known drifter origin was within 3.5 km of the spatial patch of predicted possible origins for a scenario of horizontal diffusivity (188 m2 s−1) consistent with the offshore model grid resolution. Modeled backward trajectories estimated that alewife originated from the same side of the lake where they were collected, within ~ 100 km of the collection site. Our paper demonstrates the utility of hydrodynamic models to estimate a region of origin for aged larval fish.
Dynamically Phototunable and Redox‐Responsive Hybrid Supramolecular Hydrogels for 3D Culture of Chondrocytes
Authors: Yang Weiya , Teng Lijing , Sun Xiaomin , Liu Jia , Huang Yongrui , Zhao Qi , Song Wenjing , Ren Li 
Published: July 2022

AbstractDespite the promising application of chondrocyte encapsulated within supramolecular hydrogels to create cartilage‐like tissue, matching the degradation of supramolecular hydrogels with the cartilage matrix is challenging. Here, an appropriate phototunable and redox‐responsive hybrid supramolecular hydrogel are reported through the synergic crosslinking strategy, in which the gelatinization is driven by quadruple hydrogen bonding stabilized by thermo‐triggered hydrophobic interactions of branched hyaluronic acid supramolecular polymer and dynamic disulfide bond. The non‐covalently cross‐linked network endows hydrogel scaffold with unique self‐healed and shear‐thinning behavior, while the dynamic covalent network endows hydrogels with phototunable and redox‐responsive performance. The mechanical performance of hybridized supramolecular hydrogel can be modulated by controlling photoinitiators (PI) or thiol bonds (SH) content. Besides, the gene expression, protein secretion and histological staining results show that the chondrocytes encapsulated within the hybrid supramolecular hydrogels can maintain chondrocyte phenotype and facilitate the secretion of the cartilaginous specific matrix. Thus, the developed hybrid supramolecular hydrogels hold great potential in chondrocyte carrier for chondrogenesis.
Creep and Recovery Behavior of Vitrimers with Fast Bond Exchange Rate
Authors: Perego Alessandro , Khabaz Fardin 
Published: July 2022

AbstractVitrimers encompass the desirable mechanical properties of thermosets with the recyclability of thermoplastics. This ability arises from the rearrangement of the vitrimer covalent network upon heating via a bond shuffling mechanism while its cross‐link density remains preserved. This unique feature makes vitrimers interesting candidates for the design of materials that combine dimensional stability at high temperatures and solvent resistance with the ability to be reshaped and processed. Despite these advantages, vitrimer exhibits significant creep at operating conditions where thermosets show little or no creep. As the mechanical properties of vitrimers not only depend on their chemical composition but also on the dynamics of the polymer chains, molecular dynamics (MD) simulations can provide detailed molecular mechanisms of the system of interest under macroscopic stress‐induced deformations. In this regard, the recently developed MD/Monte Carlo simulation methodology capable of capturing the bond exchange mechanics in vitrimers is used to study the creep and recovery response of a coarse‐grained model thermoset and vitrimer with a fast bond exchange rate. The time‐stress superposition principle is then successfully applied to the creep response. The resulting universal curves enable us to predict the long‐time creep behavior of both systems extending the timescale from 4 to over 10 orders of magnitude.