bluuebunny/crossref_metadata_2025_split huggingface dataset:
Copula - Based Bivariate Drought Severity and Duration Frequency Analysis Considering Spatial-Temporal Variability in the Ceyhan Basin, Turkey
Authors: Esit Musa , YUCE Mehmet Ishak 
Published: January 2022

Abstract
In recent times, copula families have been mostly employed in bivariate drought duration and severity. Archimedean copulas are mainly used conveniently among various potential families for hydrologic design and water resource management. In this study, drought events are defined by standard precipitation index (SPI 1-, 3- and 6-time series) series for 24-gauge stations in Ceyhan Basin Turkey, when the value fell below zero. Both duration and severity are tested their dependence with Mann-Kendall and Spearman Rho trend test at 0.05 significant level. The different marginal distribution function is fitted to duration and severity data. Weibull and Lognormal distribution for drought duration, Weibull and Gamma distribution for drought severity are found more appropriate, respectively. The best fit copula is found to construct a joint distribution function. However, disregarding tail dependencies can cause high uncertainty in extreme quantile predictions, resulting in incorrect hydrological design findings. Hence, the influence of upper tail dependencies is tested to select the most appropriate copula function. After acquiring the best fit copula, the joint return periods are modeled for each station. Finally, considering drought risk categories (light, moderate, severe and extreme drought), spatial distributions of drought risk-return period are constructed. Apart from using univariate frequency analysis, bivariate frequency analysis is performed to model the joint return period based on copula theory that is great of importance for hydrology design and water resource management.
Decreased Copper/Selenium Ratio Among Non-Responder Healthcare Workers to SARS-CoV-2: An Evidence of High Copper/Selenium Ratio Effects on the Immune Response to COVID-19 and Symptoms
Authors: Tashakori Mahnaz , Jamalizadeh Ahmad , Nejad-Ghaderi Mohsen , Hadavi Maryam , Yousefi-Ahmadipour Aliakbar , Moghadam Fatemeh Mohseni , Rahnama Maryam , Mashayekhi Kazem 
Published: January 2022

Abstract
Background: The relationship between strong immune response to infections and trace elements such as selenium (Se) and copper (Cu) is well documented. Furthermore, Se and Cu behave as negative and positive acute phase reactants under infectious conditions, respectively. Since SARS-CoV-2 causes systemic inflammation, this study was conducted to evaluate the association of Se and Cu serum levels with symptoms and immune response to SARS-CoV-2, and then assess the Cu/Se ratio in this matter.Methods: Blood samples and nasopharyngeal swabs were obtained from 126 SARS-CoV-2 participants with mild and severe clinical symptoms. The SARS-CoV-2 infection and immune response to the virus were confirmed by RT-PCR and anti-SARS-CoV-2 IgG, respectively. The measurement of Se and Cu serum levels were analyzed by atomic absorption spectrophotometry and colorimetric assay, respectively. Finally, data were analyzed and a P-value < 0.05 was considered statistically significant.Results: The mean Se levels were higher in patients with mild symptoms (108.73 ± 5.38 μg/L, P-value = 0.0012) and IgG non-responders (110.33 ± 3.38 μg/L, P-value < 0.001), whereas, the mean Cu was higher in participants with severe symptoms (111.055 ± 11.98 μg/dL, P-value = 0.045) and IgG responders (112 ± 9.98 μg/dL, P-value = 0.0058). The Cu/Se ratio was lower (ratio < 1) in participants with no immune responses to infection and mild symptoms versus immune responder patients with severe symptoms (P-value < 0.001).Conclusion: Our results suggest that Cu/Se ratio may be considered as a nutritional biomarker of severity and immune response in SARS-CoV-2-infected patients.
Analysis of Power Law Non-Linearity in Solitonic Solutions Using Extended Hyperbolic Function Method
Authors: Ullah Naeem , Asjad Muhammad Imran , Muhammad Taseer , Akgül Ali 
Published: January 2022

Abstract
This paper retrieves the optical solitons to Biswas-Arshed equation (BAE) which is
deliberated in the lack of self-phase modulation by applying the new extended hyperbolic
function method (EHFM). Novel constructed solutions have the shape of bright,
singular, periodic singular, and dark solitons. The achieved solutions contain key applications
in engineering and physics. These solutions define the wave performance of the
governing models, actually. The outcomes disclose that our scheme is very active and
reliable. The acquired results are illustrated by 3-D and 2-D graphs to understand the
real phenomena for such sort of non-linear models.
Investigating the Influence of Friction and Material Wear on Triboelectric Charge Transfer in Metal-Polymer Contacts
Authors: Armitage Joshua Louis , Ghanbarzadeh Ali , Bryant Michael G , Neville Anne 
Published: January 2022

Abstract
A reciprocating tribometer has been modified with a high-impedance electronic measurement circuit for the purpose of addressing the question of how tribology influences triboelectrification. This measurement circuit allows for the accurate measurement of contact potential difference (CPD) and total triboelectric charge generated within the tribometer contact. These electronic properties can now be effectively compared with tribological parameters such as contact force, relative sample velocity, and friction coefficient (μ) for varying contacts. In this study we present our apparatus, alongside our findings regarding the influence of material wear mechanisms and friction on the accumulation and dissipation of triboelectric contact charges.
Notch3 Inhibits Epithelial-to-Mesenchymal Transition by Transactivating Glycogen Synthase Kinase-3-beta–Mediated Wnt/β-catenin Signaling in Breast Cancer
Authors: Chen Wei-Ling , Zhang Yong-Qu , Li Rong-Hui , Huang Wen-He , Wei Xiao-Long , Zeng De , Liang Yuan-Ke , Zeng Yun-Zhu , Li Yao-Chen , Zhang Guo-Jun 
Published: January 2022

Abstract
As a critical transformational process in the attributes of epithelial cells, epithelial-to-mesenchymal transition (EMT) is involved in tumor invasion, metastasis, and resistance to treatment, which contributes to the ultimate death of some patients with breast cancer. Glycogen synthase kinase-3-beta (GSK3β) is thought to be an EMT suppressor that down-regulates the protein, snail, a zinc finger transcription inhibitor, and regulates E-cadherin expression and the Wnt signaling pathway. Our previous studies have shown that Notch3 also inhibits EMT in breast cancer. In mammary gland cells, GSK3β physically bound and phosphorylated the intracellular domain of two Notch paralogs: N1ICD was positively regulated but N2ICD was negatively regulated. However, the relationship between Notch3, GSK3β, and EMT in breast cancer is still unclear and crosstalk between Notch3 and GSK3β has not been widely investigated.In this study, we revealed that Notch3 was an essential antagonist of EMT in breast cancer cells by transcriptionally upregulating GSK3β. In breast cancer MCF-7 and MDA-MB-231 cell lines, the silencing of Notch3 reduced GSK3β expression, which is sufficient to induce EMT. Conversely, ectopic Notch3 expression re-activated GSK3β and E-cadherin. Mechanistically, Notch3 can bind to the GSK3β promoter directly and activate GSK3β transcription. In human breast cancer samples, Notch3 expression is positively associated with GSK3β (r=0.416, P = 0.001). Moreover, high expressions of Notch3 and GSK3β mRNA are correlated to better relapse-free survival in all breast cancer patients via analysis in “the Kaplan–Meier plotter” database.In summary, our preliminary results suggested that Notch3 might inhibit EMT by trans-activating GSK3β in breast cancer cells. The suppression of Notch3 expression may contribute to EMT by transcriptionally downregulating GSK3β in breast cancer.
Laparoscopic Treatment of The Gastro-Omental Hemangioma Hemorrhage: 2 Cases Report And Review of The Literature
Authors: Yin Long-Kuan , Liu Jian-Jun , Feng Yi-Guo , Yuan Hua-Yan , Wang Wei , Bai Xiang-Yu , Wang Pan 
Published: January 2022

Abstract
Background: Spontaneous hemorrhage of gastro-omental hemangioma is a rare disease. Such patients generally have no medical history of recent abdominal trauma, abdominal surgery, anticoagulation or systemic vascular disease. Treatment strategy of this disease variates along with its development. In the acute circumstances, surgery is somehow the first priority. Among them, laparoscopic treatment should be the most frequently considered option in the large general hospital, however, such cases are rarely reported until now.Case presentation: The present report enrolled two cases admitted with upper abdominal pain. Subsequent abdominal computed tomography (CT) scan revealed masses alongside the greater curvature of the stomach. Laparoscopic surgeries were conducted immediately and the postoperative pathological examination suggested ruptured omental hemangioma with thrombosis. Both two patients recovered smoothly after surgery, and no obvious abnormalities were complained in the follow-up period.Conclusions: Clinicians should consider the possibility of spontaneous rupture of gastro-omental hemangioma in patients with abdominal stroke. The center of medical institutions with mature technology and equipment can perform laparoscopic treatment to minimize surgical trauma and promote rapid recovery of the cases with abdominal apoplexy.
Genome of a Novel Freshwater Microcystis Cyanophage Mwe-Yong1112-1
Authors: Cai Ruqian , Li Dengfeng , Lin Wei , Qin Weinan , Pan Lingting , Wang Fei , Qian Minhua , Liu Weicai , Zhou Qin , Zhou Chengxu , Tong Yigang 
Published: January 2022

Abstract
Freshwater Microcystis cyanophage Mwe-Yong1112-1 is the first virus isolated with M. wesenbergii. The complete genome of the cyanophage is 39,679 bp in length with a G+C content of 66.6%. BLASTx scanning results indicated “No significant similarity found”. Mwe-Yong1112-1 shared the highest pair-wise average nucleotide identity (ANI) value of 60.83% (below the ≥95% boundary to define a species) and the highest nucleotide sequence similarity of 17.48% (below the >50% boundary to define a genus) with the closest phage in pairwise sequence comparison (PASC). In the proteomic tree, Mwe-Yong1112-1 formed an independent branch in Siphoviridae family. Analysis indicated that cyanophage Mwe-Yong1112-1 should be considered as a novel phage presenting a novel genus in Siphoviridae family.
Effect of Workpiece Rotational Speed on Surface Quality in YAG Double-sided Planetary Lapping With the Trajectory Method
Authors: Lei Yang , Xiaoguang Guo , renke Kang , Xianglong Zhu , Yufan Jia 
Published: January 2022

Abstract
The double-sided planetary lapping technology with fixed grit is a good candidate to process thin Y3Al5O12(YAG) crystals wafer. However, the influence of workpiece rotational speed nw in the planetary wheel on grit trajectory distribution and surface quality has not been revealed, which is of most significance to obtain a better surface workpiece. To solve this problem, the mathematical model for calculating the grit trajectory left on the workpiece in double-side lapping considering the workpiece rotation is established, and a variation coefficient for uniformity of the track point distribution (NUTPD) is introduced to evaluate the trajectory uniformity. Then, the trajectory of multiple grits and the NUTPD value at different workpiece rotational speeds were simulated in MATLAB software. The simulation result showed that the workpiece rotational speed had an extraordinary effect on the uniformity of the motion trajectory leaving on the workpiece surface. The preferred workpiece rotational speed values for lapping are nw=1,3,5,7,9. By conducting a series of tests on the YAG wafer at two typically selected rotational speeds, the surface roughness Ra and the peak-to-valley (PV) error of flatness were used to characterize the uniformity of surfaces quality. The experimental results demonstrate that there was a more uniform lapping effect, when nw=5 rpm, and the Ra and PV were 147 nm, 2.62 μm, and 141 nm, 2 μm at the upper and lower surface after lapped, which was smaller. They were 161 nm, 3.05 μm, and 149 nm, 2.74 μm after lapping when nw=6 rpm. The experimental result is consistent with the simulation result, and the feasibility and validity of the trajectory method for controlling workpiece surface quality on the planetary double-side lapping were verified.
Effects of Rainfall on Human Leptospirosis in Thailand: Evidence of Multi-Province Study Using Distributed Lag Non-linear Model
Authors: Phosri Arthit 
Published: January 2022

Abstract
Leptospirosis is a zoonotic bacterial disease that remains an important public health problem, especially in tropical developing countries. Some previous studies have revealed the outbreak of leptospirosis after heavy rain, but research determining its quantitative risks associated with rainfall in Thailand, especially at the national level, remains limited. The association between rainfall and leptospirosis was examined across 60 provinces of Thailand, and the heterogeneity of the estimated effects among provinces was also assessed. Monthly number of leptospirosis surveillance and meteorological data from 2007 to 2017 were obtained from the Bureau of Epidemiology and Thai Meteorological Department, respectively. A quasi-Poisson regression framework combined with the distributed lag non-linear model was used to estimate province-specific association between rainfall and human leptospirosis, adjusting for potential confounders. Province-specific estimates were then pooled to derive regional and national estimates using random-effect meta-analysis. The results found that the highest estimated risk of leptospirosis associated with rainfall was observed at the same month (lag 0). Using 0 cm/month of rainfall as a reference, the relative risks of leptospirosis associated with heavy (90th percentile), very heavy (95th percentile), and extremely heavy (99th percentile) rainfall at the national level were 1.0994 (95% CI: 0.9747, 1.2401), 1.1428 (95% CI: 1.0154, 1.2862), and 1.1848 (95% CI: 1.0494, 1.3378), respectively. The heterogeneity of the estimates was found among provinces ( I 2 = 27.1%, p -value <0.01), where northern and north-eastern regions were identified as the highest risk of leptospirosis associated with rainfall. In particular, relative risks of leptospirosis associated with extremely heavy rainfall in northern and north-eastern regions were 1.2362 (95% CI: 0.9110, 1.6775) and 1.2046 (95% CI: 0.9728, 1.4918), respectively. Increasing rainfall was associated with increased risks of leptospirosis, especially in the northern and northeastern regions of Thailand. This finding could be used for precautionary warnings against heavy rainfall.
Comparative proteomic analysis of glomerular proteins in primary and bucillamine-induced membranous nephropathy
Authors: Kaga Hajime , Matsumura Hirotoshi , Suzuki Takehiro , Dohmae Naoshi , Odaka Masafumi , Komatsuda Atsushi , Takahashi Naoto , Wakui Hideki 
Published: January 2022

Abstract
Background: Anti-phospholipase A2 receptor autoantibody (PLA2R Ab)-associated membranous nephropathy (MN) is the most common form of primary MN (pMN). On the other hand, bucillamine (BCL), an antirheumatic drug developed in Japan, was reported to cause a rare form of secondary MN (sMN). Between these MN forms, comparative proteomic analysis of glomerular proteins has not been performed.Methods: We used renal biopsy specimens from 6 patients with PLA2R Ab (+) pMN, 6 patients with PLA2R Ab (‒) pMN, 6 patients with BCL-induced sMN, and 5 control cases (time 0 transplant biopsies). Proteins were extracted from laser-microdissected glomeruli and analyzed using mass spectrometry. The quantification values of protein abundance in each MN group were compared with those in the control group.Results: More than 800 proteins with high confidence were identified. Principal component analysis revealed a different distribution between the pMN and sMN groups. For further analysis, 441 proteins matched with ≥3 peptides were selected. Among the pMN and sMN groups, we compared the profiles of several protein groups based on the structural and functional characteristics, such as immunoglobulins, complements, complement-regulating proteins, podocyte-associated proteins, glomerular basement membrane proteins, and several proteins that are known to be associated with kidney diseases, including MN. In all MN groups, increased levels of immunoglobulins (IgG, IgA, and IgM), complements (C3, C4, and C9), complement factor H-related protein 5, type XVIII collagen, calmodulin, polyubiquitin, and ubiquitin ligase were observed. For some proteins, such as type VII collagen and nestin, the fold-change values were significantly different between the pMN and sMN groups.Conclusions: Between the pMN and BCL-induced sMN groups, we observed common and different alterations in protein levels such as known disease-associated proteins and potential disease marker proteins. Proteomic analysis of glomerular proteins is a useful approach to improve our understanding of the pathogenesis of glomerular diseases, including MN.
An 'Intermetallic' Molecular Nanomagnet with the Lanthanide Coordinated Only by Transition Metals
Authors: Magott Michał , Brzozowska Maria , Baran Stanisław , Vieru Veacheslav , Pinkowicz Dawid 
Published: January 2022

Abstract
Magnetic molecules known as molecular nanomagnets (MNMs; or single molecule magnets SMMs) may be the key to ultra-high density data storage. A single sub-nanometer MNM is capable of storing a single bit of information while being 2-3 orders of magnitude smaller than the magnetic domains in the current HDD technology. The best performing molecular nanomagnets are designed by carefully arranging p-element donor atoms (C, N or O) around the central magnetic ion. This strategy, however, seems to be reaching its limit as the magnetic memory effect disappears above 80 K for this class of compounds. Inspired by the structure of the hardest intermetallic magnet SmCo5, we have synthesized a nanomagnetic molecule where the central lanthanide (Ln) ion ErIII is coordinated solely by three transition metal (TM) ions in a perfectly trigonal planar fashion. The molecule [ErIII(ReICp2)3] (ErRe3) constitutes the first example of a molecular nanomagnet (MNM; or single molecule magnet SMM) with unsupported Ln-TM bonds and paves the way towards molecular intermetallics with strong direct magnetic exchange interactions. Such interactions are believed to be crucial for quenching the quantum tunneling of magnetization which limits the application of Ln-SMMs as sub-nanometer magnetic memory units.
Evaluation of Saving Energy by Using the Power of Plant Composites as a Thermal Insulation; A case study: Effect of a Local Date Palm Fibers
Authors: Hajihosseini Firouzeh , Mahmoudi Jafar 
Published: January 2022

Abstract
This research focuses on assessing the potential use of the power of local palm fiber (Zahedi) as an eco-friendly composite in order to help the sustainable development. Local date palm fibers are separated into individual fibers and washed in water and then heated in an oven at 60 ° C to dry completely in order to investigation of physical properties. The developed composites were characterized in different ratio and compared in terms of physical and morphological properties. Afterwards, the analysis of scanning electron microscopy (SEM) and dispersive energy spectroscopy (EDS) from date palm fibers of Zahedi was carried out to determine the chemical and microstructure composition of the fibers. It was found that carbon and oxygen, are the only compatible and primary compounds in this palm fiber. Analyzing in the longitudinal direction of the fibers, it can be mentioned that the surface of the samples in nanoscale is irregular with many impurities, cells and pores. Also, the Scanning Electron Microscopy analysis of the fiber diameter shows the average range of the diameter is 107–135 µm. Plant-based composites were characterized in seven ratios by combining the date palm fibers with industrial cornstarch as a matrix which creates the insulator composite totally natural. The amount of thickness swelling and water absorption observed in this study was approved and appropriate for a volume ratio of 1:1 in comparison with other studied compounds. The thermal resistance of the three specimens tested by experiment. To evaluate the insulation capability, the specimens were placed at a chamber in a position to act as an obstacle to the thermal transmission. In this case, by increasing the temperature up to 80°c on one side (inside the chamber) and recording the temperature rise on the opposite side, the thermal insulation ability of the specimens was assessed. According to the results of the practical experiments, combining date palm fiber (DPF) with cornstarch resin as a matrix illustrated that the composite material is applicable, safe and useful as a thermal insulation material at a maximum of 80 °c which is appropriate for preventing heat transfer in buildings.
Prognosis of Skin cancer in Hamadan, Iran (2008-2018)
Authors: Khanlarzadeh Elham , Sobhan Mohammad Reza , Nazari Sasan , Basir Hamidreza Ghasemi , Nazari Saman 
Published: January 2022

Abstract
Objective

Skin cancer is the most common cancer in the world. The study was aimed to determine the prognosis of skin cancer in Hamadan, Iran.
Methods

A cross- sectional study was conducted retrospectively at Sina Hospital in Hamadan, Iran. A total of 3276 cases that had been diagnosed with skin cancer from 2008 to 2018 were reviewed. The variables included early symptoms, location involved, metastasis, prognosis and treatments, were recorded in checklist.
Results

The mean age of the patients were 65.30 ± 14.6 years. The highest and lowest number of skin cancers were on the nose and trunk (29.3 and 3.3%). There was also no significant relationship between radiotherapy, invasion and treatment with skin cancer. The most common pathological type of skin cancers was Basal Cell Carcinoma (BCC). The highest relative invasion was related to Melanoma (26.4%) and the lowest relative invasion was related to BCC (2.1%). The prognosis of skin cancer and 5-year survival rate of patients was 90.7%, respectively.
Conclusion

The most common age of the patients with skin cancer is in the seventh decade of life. The prognosis of patients with different types of skin cancers in this study was very good, indicating that it usually improves.
The comparison of standard and tubeless percutaneous nephrolithotomy (PCNL) in children up to 18 years old
Authors: Mousavi-bahar Seyed Habibollah , Amirhasani Shahriar , Kiani Kian , Moradi Abbas 
Published: January 2022

Abstract
Background

The Percutaneous nephrolithotomy (PCNL) is an endourological method applied as the standard or tubeless method for kidney stones treatment.
Material and Methods

In a retrospective study, 88 surgery units involving 75 children up to 18 years old with kidney stones who underwent the surgery for 8 years with one of the two methods of standard or tubeless PCNL were evaluated and compared considering the success rate of operation, hemoglobin, and hematocrit drop, medications, transfusion, duration of surgery and the length of hospital stay.
Results

Among the 88 patients, 47 cases were operated with the standard PCNL and 41 cases by tubeless method. In children whom operated by standard and tubeless PCNL, the complete success rate of operation was 87.2% and 100% (P = 0.006), the need for blood transfusion was 2.1% and 0% (P = 1.00), the need for opioids was 27.7% and 14.6% (P = 0.134), the decrease in hemoglobin was -1.82±0.94 and -1.30±0.98 mg/dl (P = 0.024), the decrease in hematocrit was -5.40±2.66 and -3.52 ± 3.11 mg/dL (P = 0.003), mean surgery duration was 109.30±53.27 and 101.46±31.92 minutes (P = 0.414), the duration of postoperative hospitalization was 3.38±1.76 and 2.46±1.27 days (P = 0.007) and the frequency of fever was 23.4% and 7.3% (P = 0.04), respectively.
Conclusion

The success rate of kidney stone surgery in children with the tubeless PCNL is higher than the standard method, and its complications are lower.