bluuebunny/crossref_metadata_2025_split huggingface dataset:
Lithuanian Sign Language Poetry: Location as Mean of Expression of Metaphors
Authors: Teresė Anželika 
Published: March 2022

In order to solve issues in sign language linguistics, address matters pertaining to maintaining high quality of sign language (SL) translation, contribute to dispelling misconceptions about SL and deaf people, and raise awareness and understand of the deaf community heritage, this article, for the first time in a Lithuanian scientific journal, discusses authentic poetry in Lithuanian Sign Language (LSL) and inherent metaphors that are created by using the phonological parameter – location. The study covered in this article is twofold, involving both the micro-level analysis of metaphors in terms of location as a sub-lexical feature and the macro-level analysis of the poetic context. Cognitive theories underlie research of metaphors in sign language poetry in a range of sign languages. The study follows this practice. In view of the abovementioned reasons, this piece of research is new and relevant to Lithuania. The article covers qualitative analysis of 10 pieces of LSL poetry. The analysis employs ELAN software widely used in sign language research. The target is to examine how specific types of location are used for the creation of metaphors in LSL poetry and what metaphors are created. The results of the study show that LSL poetry employs a range of locations resulting in a host of metaphors created by using classifier signs and by modifying the location of the established signs. The study also reveals that LSL poetry mostly tends to create reference metaphors indicating status and power. As the study shows, LSL poets metaphorically encode status by encoding another meaning in the same sign, which results in creating double metaphors. The metaphor of identity has been determined to consist of chest signing. Notably, the poetic context has revealed that the latter metaphor can also be identified as a metaphor of life. The study goes on to note that deaf poets create metaphors related to the importance of various phenomena, significance of the lyrical subject. Notably, the study has allowed detecting locations never mentioned in previous SL research as used for the creation of metaphors. For instance, previous SL research fails to cover temporal metaphors expressed by signing in central and peripheral areas and attitudinal metaphors represented by signing near the eye. The study has also detected a sign that can be identified as a metaphor of death and that is absent in previous SL research.
Refinement and Validation of a Clinical-Based Approach to Evaluate Young Febrile Infants
Authors: Yaeger Jeffrey P. , Jones Jeremiah , Ertefaie Ashkan , Caserta Mary T. , van Wijngaarden Edwin , Fiscella Kevin 
Published: March 2022

BACKGROUND AND OBJECTIVE
For febrile infants, predictive models to detect bacterial infections are available, but clinical adoption remains limited by implementation barriers. There is a need for predictive models using widely available predictors. Thus, we previously derived 2 novel predictive models (machine learning and regression) by using demographic and clinical factors, plus urine studies. The objective of this study is to refine and externally validate the predictive models.

METHODS
This is a cross-sectional study of infants initially evaluated at one pediatric emergency department from January 2011 to December 2018. Inclusion criteria were age 0 to 90 days, temperature ≥38°C, documented gestational age, and insurance type. To reduce potential biases, we derived models again by using derivation data without insurance status and tested the ability of the refined models to detect bacterial infections (ie, urinary tract infection, bacteremia, and meningitis) in the separate validation sample, calculating areas-under-the-receiver operating characteristic curve, sensitivities, and specificities.

RESULTS
Of 1419 febrile infants (median age 53 days, interquartile range = 32–69), 99 (7%) had a bacterial infection. Areas-under-the-receiver operating characteristic curve of machine learning and regression models were 0.92 (95% confidence interval [CI] 0.89–0.94) and 0.90 (0.86–0.93) compared with 0.95 (0.91–0.98) and 0.96 (0.94–0.98) in the derivation study. Sensitivities and specificities of machine learning and regression models were 98.0% (94.7%–100%) and 54.2% (51.5%–56.9%) and 96.0% (91.5%–99.1%) and 50.0% (47.4%–52.7%).

CONCLUSIONS
Compared with the derivation study, the machine learning and regression models performed similarly. Findings suggest a clinical-based model can estimate bacterial infection risk. Future studies should prospectively test the models and investigate strategies to optimize clinical adoption.
Brief Early Life Angiotensin-Converting Enzyme Inhibition Offers Renoprotection in Sheep with a Solitary Functioning Kidney at 8 Months of Age
Authors: McArdle Zoe , Singh Reetu R. , Bielefeldt-Ohmann Helle , Moritz Karen M. , Schreuder Michiel F. , Denton Kate M. 
Published: March 2022

Significance Statement
Children born with a solitary functioning kidney (SFK) can develop kidney injury as a consequence of glomerular hyperfiltration. Angiotensin-converting enzyme inhibitors (ACEis) reduce BP and are renoprotective in adults. Our study demonstrates that treatment with ACEi early in life (between weeks 4 and 8 after birth) in sheep born with a SFK prevents albuminuria and reduces glomerular hyperfiltration, thus maintaining renal functional reserve, 6 months after treatment withdrawal. Further, improvements in kidney function were associated with increased nitric oxide bioavailability. This study suggests ACEi for 1 month early in life may improve the trajectory for the development of kidney disease in individuals born with SFK.

Background
Children born with a solitary functioning kidney (SFK) are predisposed to develop hypertension and kidney injury. Glomerular hyperfiltration and hypertrophy contribute to the pathophysiology of kidney injury. Angiotensin-converting enzyme inhibition (ACEi) can mitigate hyperfiltration and may be therapeutically beneficial in reducing progression of kidney injury in those with an SFK.

Methods
SFK was induced in male sheep fetuses at 100 days gestation (term=150 days). Between 4 and 8 weeks of age, SFK lambs received enalapril (SFK+ACEi; 0.5mg/kg per day, once daily, orally) or vehicle (SFK). At 8 months, we examined BP, basal kidney function, renal functional reserve (RFR; GFR response to combined amino acid and dopamine infusion), GFR response to nitric oxide synthase (NOS) inhibition, and basal nitric oxide (NO) bioavailability (basal urinary total nitrate and nitrite [NOx]).

Results
SFK+ACEi prevented albuminuria and resulted in lower basal GFR (16%), higher renal blood flow (approximately 22%), and lower filtration fraction (approximately 35%), but similar BP, compared with vehicle-treated SFK sheep. Together with greater recruitment of RFR (approximately 14%) in SFK+ACEi than SFK animals, this indicates a reduction in glomerular hyperfiltration–mediated kidney dysfunction. During NOS inhibition, the decrease in GFR (approximately 14%) was greater among SFK+ACEi than among SFK animals. Increased (approximately 85%) basal urinary total NOx in SFK+ACEi compared with SFK animals indicates elevated NO bioavailability likely contributed to improvements in kidney function and prevention of albuminuria.

Conclusions
Brief and early ACEi in SFK is associated with reduced glomerular hyperfiltration–mediated kidney disease up to 8 months of age in a sheep model.
Characteristics of endometrial receptivity in women with different endometrial thickness
Authors: Aganezova N. V. , Aganezov S. S. , Gogichashvili K. E. 
Published: March 2022

Aim: to evaluate the expression of estrogen (ER) and progesterone (PR) receptors in the endometrium during the "implantation window" in women with a history of reproductive dysfunction with different endometrial thickness.Materials and Methods. A prospective single-center cohort comparative study was conducted. The main group included patients with hypoplastic (< 7 mm according to ultrasound data on preovulatory days) endometrium (n = 52), the comparison group consisted of women with normal endometrial thickness (n = 62) (women of both groups with reproductive dysfunctions of unclear cause), the control group included 16 healthy fertile women. An aspiration biopsy of the endometrium was performed on day 6–8 after ovulation with simultaneous collection of peripheral blood sample to measure level of estradiol (P). Endometrial biopsies were examined with histological and immunohistochemical (expression of ER, PR) methods.Results. All women had an ovulatory cycle, serum progesterone level ≥ 16.1 nmol/L (6–8 days after ovulation) and normoestrogenemia. E2/P was similar in all cohorts (p > 0.05). Indicators of endometrial expression of ER, PR, similar to healthy women (n = 16), were found in 21 % (n = 11 out of 52) and 32 % (n = 20 out of 62) in women from main and comparison groups, respectively. The remaining 79 % (n = 41 out of 52) of women with "thin" endometrium (main group) and 68 % (n = 42 out of 62) of patients with normal endometrial thickness (comparison group) had ER and PR expression indices in the endometrial glands and stroma with significant differences (p < 0.05) in all parameters (excepting PR in the endometrial stroma) from those of healthy women (control group), but without relevant differences between these cohorts (p > 0.05) regardless of endometrial thickness.Conclusion. In women with a history of reproductive disorders, parameters of ER and PR expression similar to those in women without reproductive problems, were noted with a "thin" (< 7 mm) endometrium by 50 % less often than those with normal thickness of the uterine mucosa. At the same time, the "thin" endometrium is not an absolute predictor of disorders of the hormone-receptor characteristics of the endometrium: in every fifth case, magnitude of endometrial expression ER, PR similar to healthy women were determined.
Analysis of plantar pressure during dynamic squat movement in asymptomatic volleyball athletes before and after fatigue protocol
Authors: Mora Jose Alfredo Ordenes , Serrão Ricardo José , Garcia Gabriel , Oliveira Leonardo , Federighi Baisi Chagas Eduardo 
Published: March 2022

ABSTRATO
Introdução: A fadiga é uma condição comum durante a atividade física, resultando em redução da força muscular, controle motor, equilíbrio e coordenação. Mudanças na pressão plantar muitas vezes estão relacionadas à fadiga também podem aumentar o risco de lesão. Hipótese/Objetivo: Avaliar as alterações na baropodometria durante o movimento de agachamento. A hipótese é que a pressão e a carga serão maiores na perna não dominante pós-fadiga Metodologia:Foram recrutados 28 voluntários de ambos os sexos, todos participantes ativos da equipe universitária de vôlei. A distribuição da pressão plantar foi medida durante três movimentos de agachamento. A avaliação foi realizada antes e após o protocolo de fadiga, que consistiu em quatro séries de quinze segundos de salto com dez segundos de descanso entre as séries. A análise estatística foi realizada por meio do pacote estatístico PASW 19.0 (SPSS inc.) com nível de significância adotado de 5% (p ≤ 0,05). Resultados: Para o sexo feminino, houve redução significativa de 12% na pressão média do membro dominante. Para o sexo masculino, reduções significativas na pressão média do membro dominante (7,1%) e membro não dominante (9,5%) e pico de pressão do membro dominante (13,8%) e não dominante (10,1%) . Conclusões:Os processos de fadiga reduziram a pressão plantar durante o movimento de agachamento, apresentando diferentes repercussões entre os sexos, mas ambos capazes de predispor a lesões.

Palavras-chave: Kinects; Pressão; Fadiga; Esportes; Biomecânica
The Multitaper Spectrum Analysis Package in Python
Authors: Prieto Germán A. 
Published: March 2022

Abstract
Spectral analysis has been a fundamental tool in analyzing seismic signals for studying the earthquake source, propagation of seismic waveforms through the Earth, and even monitoring changes in Earth’s structure. I present an open-source Python package, multitaper, for spectral analysis using the multitaper algorithm. The package not only includes power spectral density estimation (with confidence intervals) but also includes bivariate problems such as coherence, dual-frequency correlations, and deconvolution estimation. Implementation of the sine and quadratic multitaper algorithms is also available. For the reader to quickly learn how to use the package, I briefly present several examples using earthquake records from the 2019 Mw 6.0 Mesetas, Colombia, earthquake and its aftershocks recorded at regional distances for estimating time–frequency spectrograms, spectral ratio and source time functions, and correlations between neighboring frequencies. Jupyter Notebooks are shared to reproduce the figures.
POTENCY OF CHLORELLA SPP. AS AN ANTIOXIDANT AND ANTI-INFLAMMATORY AGENT
Authors: Cahyani Fauzia Rahma , Isman Hasna Siti Munifah 
Published: March 2022

Background: Chlorella is a natural marine product that belongs to the type of unicellular green microalgae which is currently widely used as an alternative therapy because of its secondary metabolite content which has various benefits with minimal side effects. Chlorella has also been widely studied for activities such as being an antioxidant and anti-inflammatory agent that plays a role in prevention and treatment. Purpose: This literature review aims to dig up information about the potency of Chlorella as an antioxidant and anti-inflammatory agent based on several previous studies. Review: Based on the online existing literature from the PubMed and Google Scholar databases, the results of studies on the potential of Chlorella as an antioxidant and anti-inflammatory agent were analyzed. Based on the literature review, Chlorella can act as an antioxidant and anti-inflammatory agent due to the phenolic compounds, carotenoid pigments and chlorophyll, and extracellular polysaccharides (EPS) contained in it. Conclusion: Chlorella has antioxidant and anti-inflammatory activity and has the potential to prevent and treat several types of diseases.
Drug Harm Reduction in Vietnam: A Review of Stakeholders’ Perspectives and Implications for Future Interventions
Authors: Nguyen Trang Thu , Tran Mai Thi Ngoc , Le Giang Minh , Jauffret-Roustide Marie 
Published: March 2022

Objectives. To determine how harm reduction should be applied in low-resource countries such as Vietnam by exploring the perspectives of people who use drugs (PWUD), health care professionals, and policymakers regarding methadone treatment and harm reduction strategies.Methods. We conducted 2 qualitative studies in Vietnam between 2016 and 2021. We interviewed 62 PWUD and 22 experts in drug policy development and drug treatment programs, conducted observations at methadone clinics and harm reduction program meetings, and analyzed drug policy documents.Results. PWUD considered methadone treatment only as a transition to a drug-free life. Policymakers deemed harm reduction ineffective and continued to enforce arrest and incarceration of PWUD. Drug intervention programs are not yet geared to providing specialized services. Effective communication strategies and information on evidence-based harm reduction models are inadequate to help policymakers make the right decisions.Conclusions. Harm reduction principles have not been fully adopted in Vietnam. A harm reduction strategy based on a more humanistic approach that goes beyond a biomedicalized approach is urgently needed in Vietnam and other countries in the Global South. (Am J Public Health. 2022;112(S2):S182–S190. https://doi.org/10.2105/AJPH.2022.306764 )
Validation Survey of Yellow Fever Reactive Mass Vaccination Campaign in Rural Gurage Zone, Southern Ethiopia 2021
Authors: Asrat Yosef , Sisay Chalachew , Waldetensai Abate , Wossen Mesfin , Taddesse Musse , Assefa Yonas , Abera Negash , Mohammed Ahmed , Abayneh Aschalew 
Published: March 2022

Abstract
Background: The Ethiopian public health institute reported a Yellow fever outbreak in March 2020 based on a single laboratory confirmed sample from Ethiopia's Southern nation nationalities and people region, Gurage Zone, Enor-ener district. About 702,906 people were targeted and 652,811 received the vaccine. The campaign administrative data coverage was 93%. This study validates the yellow fever vaccination coverage in the 13 districts. Method: A cluster survey was used to validate the yellow fever vaccination coverage. The sample size required was 816 people, assuming a two-sided test with a precision of 0.05, a design effect of 2.5, 17 respondents per cluster, a proportion of those with complete vaccinations based on previous administrative coverage of 93%, and a non-response rate of 5%. The sampling interval was calculated by dividing the total population of the districts by 48 (the desired number of clusters). Result: Only 813 (99.6 %) of the 816 study participants were included in the analysis. Overall, 97.5 % of people were immunized against Yellow Fever, with a 95 % confidence interval (0.962-0.985). The majority of responders (526 (64.7 %) were female, with a vaccination rate of 98.5 %. About 101 respondents (12.4 %; 95 % CI) were between the ages of 35 and 40. (10.2- 14.9). The majority of respondents (716 (89 %) with a 95 % CI (86-90) had the Yellow fever card, and 77 (9.4 %) claimed to be vaccinated, with the remaining 20 (2.6 %) not vaccinated. Yellow fever vaccine coverage was 96 % in Chaha district; 95 % CI (93.1-97.9), 97.7 % in Abeshge district; 95 % CI (94.2-99.3), 100 % in Wolkite; 95 % CI (94-100), 98.3 % in Enor-ener district; 95 % CI (95.8-99.5), and 100 % in Gunchire (89-100). The adverse events following immunization were fever 0.4%, headache 0.4% and seizure 0.1%. Conclusion: According to this survey, there were data disparities between the survey and administrative data in the mass vaccination program coverage estimate. The mass vaccination campaign against yellow fever in the selected five districts were successful since the estimated coverage exceeded the desired threshold of 80%.
Minimal non-abelian nodal braiding in ideal metamaterials
Authors: Qiu Chunyin , Qiu Huahui , Zhang Qicheng , Liu Tingzhi , Fan Xiying , Zhang Fan 
Published: March 2022

Abstract
Exploring new topological phases and phenomena has become a vital topic in condensed matter physics and material sciences. Recent studies reveal that a braided colliding nodal pair can be stabilized in a multi-gap system with PT or C_2z T symmetry. Beyond the conventional single-gap abelian band topology, this intriguing phenomenon exemplifies non-abelian topological charges. Here, we construct ideal acoustic metamaterials to realize non-abelian braiding with the fewest band nodes. We experimentally observe an elegant but nontrivial nodal braiding process, including nodes creation, braiding, collision, and repulsion (i.e., failure to annihilate), and measure the mirror eigenvalues to elucidate the essential braiding consequence. The latter, at the level of wavefunctions, is of prime importance since the braiding physics essentially aims to entangle multi-band wavefunctions. Furthermore, we experimentally unveil the highly intricate correspondence between the edge responses and the bulk non-abelian charges. Our findings pave the way for developing non-abelian topological physics that is still in its infancy.
Proteomic study of hepatic apoptosis induced by overexpression of G0S2
Authors: Qiu Yaxin , Zhou Xiaoming , Zhang Zhenyuan , Sun Wenxiu , Ma Shizhan 
Published: March 2022

Abstract
Background: G0S2 was initially identified in blood mononuclear cells after the induction of cell cycle progression. The translation of G0S2 produces a small basic protein 103 amino acids in length. Initially, G0S2 was thought to mediate re-entry into the cell cycle by promoting the transition from the G0 to the G1 phase. Recent studies have identified roles for G0S2 in cancer, inflammation, and various metabolic processes. In lipid metabolism, G0S2 binds to ATGL and inhibits lipolysis. G0S2 also binds specifically to BCL-2 and inhibits the formation of the antiapoptotic body BCL-2/Bax, which in turn favors apoptosis. Whether there are other mechanisms and the proteins involved in these processes are not known; therefore, we used proteomics to identify differentially expressed proteins related to G0S2.Methods: G0S2-overexpressing adenovirus was injected into C57/BJL mice, the livers were collected, and proteins were identified by mass spectrometry. The identified proteins were analyzed by Gene Ontology (GO) and KEGG.Results: In total, 3765 liver proteins were identified, of which 3745 were quantified. The expression of 320 proteins was found to be upregulated, and that of 101 proteins was downregulated. These results indicated that G0S2 overexpression significantly altered the proteomic profile. There were 63 differential proteins involved in apoptosis, of which 45 were up-regulated and 18 were down-regulatedConclusion: Our preliminary study showed that G0S2 overexpression in the liver led to specific protein spectrum changes, with 63 differentially expressed proteins involved in the regulation of apoptosis, elucidating an important relationship between G0S2 and apoptosis. This finding indicated that G0S2 may involve in cancer, neurodegenerative diseases and numerous metabolic diseases an apoptotic factor, providing new insights into the mechanisms of disease development.
Structural synthesis of the new type 4DOF robot manipulators for industry and medicine
Authors: Soltanov Suleyman 
Published: March 2022

Abstract
Different types of overconstrained \({\left\{d\right\}}_{0}^{5}\) robot manipulators are widely applied in industry and medicine. By applying advanced scientific approaches, the design of the new type of serial and parallel overconstrained robot manipulators with wider working zone, high speed and less singular configuration is an actual issue. In this research work, the structural synthesis of the new type of spatial serial and parallel type robot manipulators with four degrees of freedom (4DOF) is performed by using the transformation of a plane-cylinder (\(PC\)) higher kinematic pair. In this case, the number of spatial mobility \(\lambda = 4\) and the number of constraints \(d = 2\) for the plane-cylinder higher kinematic pair are found with analytical method. For each of the designed spatial serial and parallel type 4DOF robot manipulators, along the gripper has the same mobility in the subspace \({\left\{{\lambda }_{i}\right\}}_{1}^{5}\), the direction of their constraints is determined by applying different configurations on the coordinate axes (revolute and translation on \(x, y, z\) axes). The 3D models of the newly designed 4DOF robot manipulators are indicated in the tables, and new 4DOF robot manipulators specially designed to be used in industry and medicine are presented.