bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sleep and eye disease: A review
Authors: Lee Samantha S. Y. , Nilagiri Vinay K. , Mackey David A. 
Published: March 2022

AbstractThere is a growing body of literature on the effects of sleep disorders, in particular obstructive sleep apnoea (OSA), on ocular health, with consistent evidence of an increased risk of floppy eyelid syndrome, non‐arteritic anterior ischaemic optic neuropathy, diabetic macular oedema, and other retinal vasculature changes in individuals with OSA. However, reports on OSA's associations with glaucoma, papilloedema, diabetic retinopathy, central serous chorioretinopathy, and keratoconus have been conflicting, while links between OSA and age‐related macular degeneration have only been described fairly recently. Despite numerous suggestions that OSA treatment may reduce risk of these eye diseases, well‐designed studies to support these claims are lacking. In particular, the ocular hypertensive effects of continuous positive airway pressure (CPAP) therapy for OSA requires further investigation into its potential impact on glaucoma risk and management. Reports of ocular surface complications secondary to leaking CPAP masks highlights the importance of ensuring good mask fit. Poor sleep habits have also been linked with increased myopia risk; however, the evidence on this association remains weak.
Quantifying the impact of economic sanctions on international trade in the energy and mining sectors
Authors: Larch Mario , Shikher Serge , Syropoulos Constantinos , Yotov Yoto V. 
Published: March 2022

AbstractWe study the impact of economic sanctions on international trade in the mining sector. We demonstrate that the gravity equation is well‐suited to model bilateral trade costs in mining and find that sanctions have been effective in impeding mining trade. Complete trade sanctions have reduced mining trade by about 44% on average. We also document significant heterogeneity in the sanctions effects on mining trade across industries, sanction episodes/cases, depending on the sanctioning and sanctioned countries, the type of sanctions, and the direction of trade. We take a close look at the impact of recent sanctions on Iran and Russia.
Chronic Pain and the Arcs of Suffering and Well‐Being: A Systems Model of/for Living with Psoriatic Arthritis
Authors: Singstock Mitchell , Hay M. Cameron , Hyland Kerby 
Published: March 2022

AbstractChronic pain is a phenomenon in which the biological sensations of pain interact synergistically with an individual's cultural world. Considerable anthropological work has been done on the senses and on the anthropology of chronic pain. Less attention has been given to the sensations of chronic pain, how they can escalate to suffering, and how they may be managed in daily life to enable well‐being. To develop an integrated understanding of chronic pain processes, we worked as a collaborative research team that included a patient coauthor. Together we synthesized a model that outlines the biological pathways of pain while taking into account the cultural factors that can magnify pain into arcs of suffering or temper pain toward arcs of well‐being. Drawing on scholarly literature, long‐term ethnographic research, and personal experience with autoimmune disease, we propose a dynamic model of the moment‐to‐moment arcs that maintain, magnify, or temper pain. [pain, suffering, well‐being, autoimmune disease, and systems model]Spanish abstract: El dolor crónico es un fenómeno en el que las sensaciones biológicas del dolor son sinérgicamente interactivas con el mundo cultural del individuo. Ha sido mucho trabajo antropológico en los sentidos y la antropología del dolor crónico. Menos atención ha prestado a las sensaciones del dolor crónico, su crecimiento a sufrimiento y cómo estas sensaciones pueden ser manejadas en la vida cotidiana para facilitar el bienestar. El desarrollo de un entendimiento integrativo de los procesos del dolor crónico exigió un equipo de investigación integrativo y colaborativo, lo que incluyó un paciente como coautor. Juntos, resumimos un modelo que esboza las vías biológicas del dolor mientras abarcando los factores culturales que amplifican el dolor a ciclos de retroalimentación de sufrimiento o, alternativamente, templan el dolor a ciclos de retroalimentación de bienestar. Con el apoyo de literatura académica, investigaciones en etnografía prolongadas y experiencia personal de enfermedades autoinmunitarias, propongamos un modelo dinámico de ciclos de retroalimentación instantáneos que mantienen, magnifican otemplan el dolor. [dolor, sufrimiento, bienestar, enfermedad autoinmune, modelo sistemático]
Effects of BMAL1 on dentinogenic differentiation of dental pulp stem cells via PI3K/Akt/mTOR pathway
Authors: Xu Hui , Zhao Jiajia , Chen Guangjin , Yuan Zhenglin , Liu Jiarong 
Published: March 2022

AbstractAimThis study aimed to investigate the effect of the circadian clock gene Bmal1 on dentinogenic differentiation of dental pulp stem cells (DPSCs) under inflammatory conditions.MethodologyDental pulp stem cells were isolated from the pulp tissue of the healthy donor and were then stimulated with different concentrations of lipopolysaccharide (LPS) to mimic inflammatory conditions. Real‐time polymerase chain reaction was used to detect the gene expression of circadian clock genes Bmal1, Clock, Per1, Per2, Cry1, and Cry2. Western blot (WB) was applied to analyse the protein expression of circadian clock proteins (BMAL1, CLOCK) and dentinogenic differentiation‐related proteins (DSPP, DMP1). In addition, the apoptosis and osteogenic differentiation of DPSCs were also analysed in the presence of different concentrations of LPS.ResultsThe expression of circadian clock genes of DPSCs significantly changed in an inflammatory environment. WB analysis shows that BMAL1 is relevant to the dentinogenic differentiation of DPSCs. In low concentrations of LPS‐mimicked inflammatory conditions, the expression of BMAL1 increased and promoted the dentinogenic differentiation of DPSCs. However, under high concentrations of LPS‐mimicked inflammatory conditions, the expression of BMAL1 decreased and inhibited the dentinogenic differentiation of DPSCs. Moreover, the effects of BMAL1 on dentinogenic differentiation of DPSCs may be through PI3K/Akt/mTOR pathway.ConclusionsThis study showed that the circadian clock gene Bmal1 affected dentinogenic differentiation of DPSCs, providing a new insight for clinical stem cell‐based restorative dentinogenesis therapies.
Modeling heat transfer during hot water sanitization of a commercial mushroom slicer
Authors: Lele Saurabh R. , Takhar Pawan S. , Anantheswaran Ramaswamy C. 
Published: March 2022

AbstractA heat transfer model within a three‐lane mushroom slicer was solved using the Finite Element Method (FEM) to obtain a conservative estimate of the temperature at the cold spot within the slicer during hot water sanitization under natural convection. Computational fluid dynamics (CFD) modeling of the heating of a single spacer by hot water under natural convection showed that the bottom surface of the spacer heated slower compared to the top surface. This was due to buoyancy forces and density gradients during natural convection leading to the formation of a wake of cold water at the bottom of the spacer. The FEM model predicted the location of the cold spot during hot water sanitization under natural convection to be at the bottom inside surface of a spacer at the center of the upper shaft and this agreed with the experimentally determined time–temperature data. The experimentally determined time for the cold spot to reach the target temperature during sanitization at 65°C was 5.2 min, whereas that predicted by the FEM model was 6.1 min. It is recommended that the higher value of the time to reach the target temperature at the cold spot as predicted by the FEM model be used as a come‐up time to establish the minimum treatment times for sanitization at 65°C.Practical ApplicationsMany of the mushroom processing facilities use a three‐lane mushroom slicer manufactured by DutchTecSource (Netherlands). A practice used currently in the mushroom industry for routine sanitization of mushroom slicers is heating the slicer head in boiling water for an hour. Studies at Penn State have shown that Listeria monocytogenes can be eliminated from food contact surfaces using hot water sanitization. In order to validate sanitization treatments in a mushroom slicer, it is imperative to determine cold spots and the come‐up times to reach the target temperature therein. Since the geometry of this commercial three‐lane mushroom slicer is highly irregular, a FEM‐based approach was used to model heat transfer. The data obtained from this study can be used by mushroom processors to establish the minimum treatment times for hot water sanitization of commercial mushroom slicers.
Contributions of extended batch tests for assessing technical recyclability: A case study of low‐value battery flows
Authors: Mählitz Paul Martin , Korf Nathalie , Chryssos Georgios , Rotter Vera Susanne 
Published: March 2022

AbstractGood product recyclability is a prerequisite for the transition to a circular economy. However, today's product complexity and diversity in the urban mine result in heterogeneous and variable waste flows affecting process recycling efficiency (RE) and thus product recyclability. For batteries, waste flow composition and subsequent RE are determined by usage behavior, collection, and sorting into chemical battery subsystems. This study aims to demonstrate how extended batch tests (EBTs) can be used as a method to (a) determine battery‐specific RE and (b) derive recommendations for assessing and improving the recyclability of batteries. Three EBTs comprising extensive characterization methods were carried out with mixtures of zinc‐based (AZ) and lithium‐based (LIB) batteries. The results showed that 0.20–0.27 kg/kg of the input mass was lost through flue gas and not recyclable. The metal fraction (0.15–0.19 kg/kg) was easily recyclable, while the mineral fractions of LIBs posed challenges for recycling and recovery (RR) due to the high elemental heterogeneity and pollutants originating from individual battery subsystems. In total, 0.79 kg/kg of AZs was recyclable, whereas 0.52 kg/kg of LIBs and 0.58 kg/kg of AZLIBs (a mixture of both) were recyclable after further treatment. In conclusion, the study demonstrated how the EBT approach can be used to extend recyclability assessment by providing waste flow characteristics for comparison with output quality requirements, enabling assignment of battery‐specific RE and identification of poorly recyclable battery subsystems. Thus, the EBT approach can help improve and assess technical recyclability in the future.
Anachronic: Viral Socialities and Project Time among HIV Support Groups in Barbados
Authors: Murray David A. B. 
Published: March 2022

AbstractFrom 2005 to 2015, up to five support groups for people living with HIV (PLHIV) operated in Barbados. However, by early 2020, all but one had disappeared. What caused the demise of these groups and why? What does this demise tell us about the HIV response in Barbados, and more particularly, everyday life for PLHIV? More generally, what does it tell us about “viral socialities” (ties formed between groups of people as they confront the lived effects of infection and discrimination attributable to HIV) and the effects of “project time” (a time frame delimited through the priorities of global HIV/AIDS agencies) on these socialities? Through ethnographic and archival research methods, this article reveals how multiple, unstable project times create and transform viral socialities of Barbadian PLHIV with anachronic effects for some—i.e., a sense of alienation or being “out of time” in relation to the priorities of the global HIV response.
Cyphoderia ampulla(Cyphoderiidae: Rhizaria), a tale of freshwater sailors: The causes and consequences of ecological transitions through the salinity barrier in a family of benthic protists
Authors: González‐Miguéns Rubén , Soler‐Zamora Carmen , Useros Fernando , Nogal‐Prata Sandra , Berney Cédric , Blanco‐Rotea Andrés , Carrasco‐Braganza María Isabel , de Salvador‐Velasco David , Guillén‐Oterino Antonio , Tenorio‐Rodríguez Daniel , Velázquez David , Heger Thierry J. , Sanmartín Isabel , Lara Enrique 
Published: March 2022

AbstractThe salinity barrier that separates marine and freshwater biomes is probably the most important division in biodiversity on Earth. Those organisms that successfully performed this transition had access to new ecosystems while undergoing changes in selective pressure, which often led to major shifts in diversification rates. While these transitions have been extensively investigated in animals, the tempo, mode, and outcome of crossing the salinity barrier have been scarcely studied in other eukaryotes. Here, we reconstructed the evolutionary history of the species complexCyphoderia ampulla(Euglyphida: Cercozoa: Rhizaria) based on DNA sequences from the nuclear SSU rRNA gene and the mitochondrialcytochrome oxidase subunit Igene, obtained from publicly available environmental DNA data (GeneBank, EukBank) and isolated organisms. A tree calibrated with euglyphid fossils showed that four independent transitions towards freshwater systems occurred from the mid‐Miocene onwards, coincident with important fluctuations in sea level. Ancestral trait reconstructions indicated that the whole family Cyphoderiidae had a marine origin and suggest that ancestors of the freshwater forms were euryhaline and lived in environments with fluctuating salinity. Diversification rates did not show any obvious increase concomitant with ecological transitions, but morphometric analyses indicated that species increased in size and homogenized their morphology after colonizing the new environments. This suggests adaptation to changes in selective pressure exerted by life in freshwater sediments.
Implications of “slower” ventricular tachycardia on clinical management and detection and therapy function of implantable cardioverter defibrillators
Authors: Kantharia Bharat K. , Shah Arti N. 
Published: March 2022

AbstractSophisticated dual‐chamber atrioventricular and rate‐responsive pacing therapies, cardiac resynchronization therapy (CRT), detection and therapies for ventricular tachycardia and fibrillation (VT/VF) form some major components of multitask functions of current implantable cardioverter defibrillators (ICDs). Appropriate programming of these devices is necessary for them to perform all such tasks precisely. In this report, we describe a case of a patient with Chagas cardiomyopathy with marked cardiomegaly, scarred ventricles, prior epicardial and endocardial ablations and on antiarrhythmic pharmacotherapy for VT, who presented with symptomatic wide complex tachycardia at a slower rate than definition of VT, and in whom programming for detection and therapy for “slow” VT could not be performed due to default technological limitation of the CRT‐D.
Prospects for Augmenting Team Interactions with Real‐Time Coordination‐Based Measures in Human‐Autonomy Teams
Authors: Wiltshire Travis J. , van Eijndhoven Kyana , Halgas Elwira , Gevers Josette M. P. 
Published: March 2022

AbstractComplex work in teams requires coordination across team members and their technology as well as the ability to change and adapt over time to achieve effective performance. To support such complex interactions, recent efforts have worked toward the design of adaptive human‐autonomy teaming systems that can provide feedback in or near real time to achieve the desired individual or team results. However, while significant advancements have been made to better model and understand the dynamics of team interaction and its relationship with task performance, appropriate measures of team coordination and computational methods to detect changes in coordination have not yet been widely investigated. Having the capacity to measure coordination in real time is quite promising as it provides the opportunity to provide adaptive feedback that may influence and regulate teams’ coordination patterns and, ultimately, drive effective team performance. A critical requirement to reach this potential is having the theoretical and empirical foundation from which to do so. Therefore, the first goal of the paper is to review approaches to coordination dynamics, identify current research gaps, and draw insights from other areas, such as social interaction, relationship science, and psychotherapy. The second goal is to collate extant work on feedback and advance ideas for adaptive feedback systems that have potential to influence coordination in a way that can enhance the effectiveness of team interactions. In addressing these two goals, this work lays the foundation as well as plans for the future of human‐autonomy teams that augment team interactions using coordination‐based measures.
How to Cover Additional Cooling Load Needs During COVID-19 Pandemic?
Authors: Erdemir Dogan , Dincer Ibrahim 
Published: March 2022

Abstract
It has been crystal clear to everyone that the fresh air supply is one of the highest priorities to keep people under safe indoor conditions during the COVID-19 pandemic. In many buildings, either there are no mechanical ventilation systems or the air conditioning systems do not have adequate capacity to meet the additional cooling loads for the increased fresh air requirement. Providing fresh air without disturbing the thermal conditions in the building requires a substantially increased cooling load and operating costs. On the other hand, there may not be adequate power infrastructure to meet this additional energy demand item in many regions. In this technical brief paper, we aim to emphasize the importance of heat storage systems and provide a quick solution to illustrate that they can meet the fresh air demands without requiring additional chiller or chiller capacity. In addition, it is observed that heat storage systems can be a convenient solution to meet the urgent and additional cooling loads in a more sustainable way.
UK poSt Arthroplasty Follow-up rEcommendations (UK SAFE): what does analysis of linked, routinely collected national datasets tell us about mid–late term revision risk after knee replacement?
Authors: Smith Lindsay K , Garriga Cesar , Kingsbury Sarah R , Pinedo-Villanueva Rafael , Delmestri Antonella , Arden Nigel K , Stone Martin , Conaghan Philip G , Judge Andrew 
Published: March 2022

ObjectiveTo identify patients at risk of mid-late term revision of knee replacement (KR) to inform targeted follow-up.DesignAnalysis of linked national datasets from primary and secondary care (Clinical Practice Research Datalink (CPRD GOLD), National Joint Registry (NJR), English Hospital Episode Statistics (HES) and Patient Reported Outcome Measures (PROMs)).ParticipantsPrimary elective KRs aged ≥18 years.Event of interestRevision surgery ≥5 years (mid–late term) postprimary KR.Statistical methodsCox regression modelling to ascertain risk factors of mid–late term revision. HRs and 95% CIs assessed association of sociodemographic factors, comorbidities, medication, surgical variables and PROMs with mid–late term revision.ResultsNJR-HES-PROMs data were available from 2008 to 2011 on 188 509 KR. CPRD GOLD-HES data covered 1995–2011 on 17 378 KR. Patients had minimum 5 years postprimary surgery to end 2016. Age and gender distribution were similar across datasets; mean age 70 years, 57% female. In NJR, there were 8607 (4.6%) revisions, median time-to-revision postprimary surgery 1.8 years (range 0–8.8), with 1055 (0.6%) mid–late term revisions; in CPRD GOLD, 877 (5.1%) revisions, median time-to-revision 4.2 years (range 0.02–18.3), with 352 (2.0%) mid–late term revisions.Reduced risk of revision after 5 years was associated with older age (HR: 0.95; 95% CI 0.95 to 0.96), obesity (0.70; 0.56 to 0.88), living in deprived areas (0.71; 0.58 to 0.87), non-white ethnicity (0.58; 0.43 to 0.78), better preoperative pain and functional limitation (0.42; 0.33 to 0.53), better 6-month postoperative pain and function (0.33; 0.26 to 0.41) or moderate anxiety/depression (0.73; 0.63 to 0.83) at primary surgery.Increased risk was associated with male gender (1.32; 1.04 to 1.67); when anticonvulsants (gabapentin and pregabalin) (1.58; 1.01 to 2.47) or opioids (1.36; 1.08 to 1.71) were required prior to primary surgery.No implant factors were identified.ConclusionThe risk of mid–late term KR revision is very low. Increased risk of revision is associated with patient case-mix factors, and there is evidence of sociodemographic inequality.
Internet-based cognitive-behavioural writing therapy for reducing post-traumatic stress after severe sepsis in patients and their spouses (REPAIR): results of a randomised-controlled trial
Authors: Gawlytta Romina , Kesselmeier Miriam , Scherag Andre , Niemeyer Helen , Böttche Maria , Knaevelsrud Christine , Rosendahl Jenny 
Published: March 2022

ObjectivesTo investigate the efficacy, safety and applicability of internet-based, therapist-led partner-assisted cognitive-behavioural writing therapy (iCBT) for post-traumatic stress disorder (PTSD) symptoms after intensive care for sepsis in patients and their spouses compared with a waitlist (WL) control group.DesignRandomised-controlled, parallel group, open-label, superiority trial with concealed allocation.SettingInternet-based intervention in Germany; location-independent via web-portal.ParticipantsPatients after intensive care for sepsis and their spouses of whom at least one had a presumptive PTSD diagnosis (PTSD-Checklist (PCL-5)≥33). Initially planned sample size: 98 dyads.InterventionsICBT group: 10 writing assignments over a 5-week period; WL control group: 5-week waiting period.Primary and secondary outcome measuresPrimary outcome: pre–post change in PTSD symptom severity (PCL-5). Secondary outcomes: remission of PTSD, depression, anxiety and somatisation, relationship satisfaction, health-related quality of life, premature termination of treatment. Outcomes measures were applied pre and post treatment and at 3, 6 and 12 months follow-up.ResultsTwenty-five dyads representing 34 participants with a presumptive PTSD diagnosis were randomised and analysed (ITT principle). There was no evidence for a difference in PCL-5 pre–post change for iCBT compared with WL (mean difference −0.96, 95% CI (−5.88 to 3.97), p=0.703). No adverse events were reported. Participants confirmed the applicability of iCBT.ConclusionsICBT was applied to reduce PTSD symptoms after intensive care for sepsis, for the first time addressing both patients and their spouses. It was applicable and safe in the given population. There was no evidence for the efficacy of iCBT on PTSD symptom severity. Due to the small sample size our findings remain preliminary but can guide further research, which is needed to determine if modified approaches to post-intensive care PTSD may be more effective.Trial registration numberDRKS00010676.