bluuebunny/crossref_metadata_2025_split huggingface dataset:
Пригоди героя «Дольчевіти» Р. Малиновського у просторі гетеротопії
Authors: Мусій Валентина 
Published: June 2022

Метою статті є дослідження оповідання сучасного українського письменника Романа Малиновського в антропологічному аспекті. Новизна статті полягає в тому, що оповідання «Дольчевіта» уперше включено у простір літературознавчих досліджень і взагалі, і в зазначеному теоретичному аспекті. Увагу сфокусовано на ознаках гетеротопії кризового типу в картині перебування героя оповідання в літаку (поза межами конкретного й звичного для нього географічного простору). При цьому виявляються типологічні ознаки гетеротопії шляхом її порівняння з міфопоетичною та науковою моделями світу. Про гетеротопічність простору в оповіданні Р. Малиновського свідчить передовсім те, що він є для героя «іншим», що герой тимчасово також перевтілюється тут у нібито нову («іншу») людину: забуває про свої прихильності, моделює цілком віртуальну (схожу на кіно) історію своїх стосунків з незнайомою жінкою. Образ самої жінки також максимально позбавлений конкретності (невідомі ні її голос, ні її ім’я, ні її почуття, мета подорожування і так інше), тому загадкову красуню, про яку фантазує герой, можна визначити як «будь хто», «будь яка». Практичне значення. Дослідження доповнює картину процесу розвитку сучасної української прози, ним запропоновано один з напрямів вивчення суб’єктного плану художнього твору.
Концептуальний погляд на життя 90-х рр. у спогадах професора Романа Гром’яка «Вертеп» і «Вертеп-2»: наратив та поетика
Authors: Оляндер Луїза 
Published: June 2022

Мета. Стаття присвячена аналізу концептуальних поглядів на життя видатного українського вченого Романа Теодоровича Гром’яка (1937–2013) у денниках «Вертеп» (1992) та Вертеп-2 (1995), які розглядаються через поетику. Дослідницька методика. У процесі аналізу використаний синтез основоположних методів і принципів наукового дослідження, серед яких передусім герменевтичний, текстовий, типологічний, поетологічний, біографічний у їхніх взаємозв’язках та доповнюваності. Результати дослідження. У статті послідовно і всебічно розкривається проблема соціальних, політичних та філософських поглядів ученого на життя та людину в ньому на початку 90-х рр. ХХ ст. в Україні, акцентована специфіка і поетика авторського дискурсу, підкреслено його смислотворча функція, завдяки чому розширились можливості для поглибленого осмислення історичного значення «Вертеп-1» (1992) та «Вертеп-2» (1995), котрий доказово представлений як унікальний і масштабний людський документ початкового періоду становлення незалежної України. Наукова новизна. У ході дослідження через поетику схарактеризовано внесок Р. Гром’яка в наукове осмислення специфічних рис епохального часу України в його денниках через мовну акцентуацію, соціальний і психологічний стан окремої людини та її поведінку, а також через саморозкриття автора-наратора, Зосереджено увагу на органічному поєднанні об’єктивного опису з публіцистикою через організацію (полі)діалогічних ситуацій. Практичне значення. Отримані результати дослідження можуть бути використані для подальшого вивчення історії України через людський документ із зіставленням свідчень інших письменників, зокрема Д. Павличка, І. Драча та ін., які виступали з доповідями та критичними статтями. Наукові спостереження та висновки можуть бути покладені в основу лекційних курсів у вишах з історії української літератури ХХ століття і теорії літератури, а також і в шкільному викладанні українського красного письменства.
How Did the Translation of Genovefa by Christoph von Schmidt Become the 19th-Century Lithuanian Vestseller?
Authors: Navickienė Aušra 
Published: June 2022

This article analyses the repertoire of nineteenth-century Lithuanian fiction to identify cases of bestsellers and to reconstruct their publishing history. The concept of nineteenth-century Lithuanian fiction publication is broadly understood. It includes fiction printed in the Lithuanian language in Lithuania, Lithuania Minor and the Lithuanian emigration from 1795, when the third partition of Poland and Lithuania took place and the lands of the Grand Duchy of Lithuania were annexed by Russian empire, until 1904, when the ban on printing in Latin script, which lasted for four decades after 1864, was lifted. The history of the translation and publication of German writer Christoph von Schmidt’s work Genovefa was selected as a study case. A study was conducted to find answers to various issues: Does this publication with its fifteenth editions qualify as the Lithuanian bestseller? What factors led to the large number of new editions of this title? How did contrafactions (publications with intentionally false imprints) contribute to book sales during the ban on publishing in Latin characters in Lithuania? The research findings reveal publishing trends characteristic of Europe in a phase of modernisation (new business models of the publishing industry, growing public literacy and changing public demand for reading material). In addition, they show the peculiarities of nineteenth-century book publishing and the book trade in the European regions involved in a struggle against occupation and for the preservation of their national identities.
Primary mediastinal large B-cell lymphoma with a rare <i>ALK</i> gene mutation
Authors: Kit O. I. , Kamaeva I. A. , Lysenko I. B. , Novikova I. A. , Timoshkina N. N. , Nikolaeva N. V. , Gaisultanova Ya. S. , Khamaneva N. Yu. , Pushkin A. A. 
Published: June 2022

Introduction. Primary mediastinal large B-cell lymphoma is an aggressive variant of lymphoma characterized by genetic heterogeneity. First-time therapy for primary mediastinal large B-cell lymphoma usually includes immunochemotherapy. However, a substantial proportion of patients do not respond to this therapy.Objective – to analyze clinical characteristics of primary refractory primary mediastinal large B-cell lymphoma taking into account the results of targeted next-generation sequencing (NGS).Materials and methods. A 22‑year-old patient with primary mediastinal large B-cell lymphoma who had not responded to immunochemotherapy was tested using targeted NGS for 77 genes.Results. We identified 2 rare mutations in the ALK gene with an unclear clinical value. According to the literature, these mutations are primarily found in solid tumors.Conclusion. Missense mutations identified in the ALK gene are presumably associated with the course of primary mediastinal large B-cell lymphoma, in particular, with primary refractory disease.
Antitumor effect of recombinant interferon-gamma in an experimental model of Ehrlich’s bilateral solid carcinoma
Authors: Isaeva V. G. , Grivtsova L. Y. , Zhovtun L. P. , Samborsky S. M. , Falaleeva N. A. 
Published: June 2022

Introduction.Immunotherapy, which is part of the complex and combined cancer therapy, is one of the priority areas in the treatment of cancer patients. However, the effectiveness of the use of immunotherapeutic drugs of the latest generation is not so high, and in some patients the effect of therapy was short-lived. Factors that prevent the full realization of the antitumor effect of cytostatics and immunopreparations may be the features of the antigenic composition of the tumor, as well as its cellular and stromal microenvironment. These facts contributed to the development of a new strategy, designated as immunoredaction of cancer by exposure to various biologically active agents that can change the body – tumor ratio in favor of the patient and make the tumor available for the implementation of antitumor effects of the host immune system.The study objective– experimental substantiation of the development of new immunotherapeutic approaches in the treatment of aggressive forms of cancer.Materials and methods.An experimental study of the effect of human recombinant interferon-gamma (IFNγ) on the growth of Ehrlich’s carcinoma during subcutaneous bilateral transplantation of tumor cells to animals was carried out. Transplantation of Ehrlich’s carcinoma to male F1 hybrids (SWAhC57Bl6) was performed by subcutaneous injection of 2.0 × 106 tumor cells (7‑day culture) in 0.1 ml of suspension into the lateral surface of the right and left femur with imitation of multicentric growth.Results.A day after the course of drug administration (day 6 of tumor node growth), the effect of suppressing tumor growth in relation to growth in the control group was noted. The maximum inhibition effect of 19.8 % (p<0.05) of tumor growth was obtained 5 days after the course of the drug (10 days of tumor growth, right node) and 18.5 % (p<0.001) 9 days after administration (14 days of tumor growth, left node).Conclusion.Thus, a distinct, statistically significant antitumor effect of IFNγ was established in relation to a tumor with a multicentric growth pattern.
The results of next-generation sequencing in men with borderline QT interval prolongation (pilot study)
Authors: Orlov P. S. , Ivanoshchuk D. E. , Nesterets A. M. , Kuznetsov A. A. , Ivanova A. A. , Maliutina S. K. , Denisova D. V. , Striukova E. V. , Maksimov V. N. , Maksimova S. V. 
Published: June 2022

Highlights. Probably causal mutations of QT interval prolongation in genes associated with LQTS were found in men of the Siberian population.Aim. To detect and study mutations in individuals with borderline prolongation of the QT interval in Siberian males.Methods. The study was conducted on the material of the international project HAPIEE in the period from 2003 to 2005 and screening of young people aged 25–44, performed in Novosibirsk. The total sample of men was 1353 people aged 25 to 69 years. From each age subgroup (25–29, 30–34, ..., 65–69 years old) 2–3 samples with the highest QT values were selected . The study group consisted of 30 men who subsequently underwent sequencing of a panel of genes. The search for mutations was carried out in genes associated with long QT syndrome (LQTS): KCNQ1, KCNH2, SCN5A, KCNE1, KCNE2, KCNJ2, CACNA1, SCN4B, KCNJ5, ANK2, CAV3, SNTA1, AKAP9, CALM1 and CALM2. All identified single nucleotide variants were verified by direct Sanger sequencing.Results. Three rare variants in the LQTS genes have been identified: p.P197L of the KCNQ1 gene, p.R176W, and p.D1003GfsX116 of the KCNH2 gene.Conclusion. In Caucasian men from the Novosibirsk population with borderline prolongation of the QT interval, probably causal substitutions in the LQTS genes – KCNH2 and KCNQ1, contributing to the prolongation of the QT interval, were found. To clarify the spectrum and frequency of occurrence of various mutations in genes, life-threatening arrhythmias in the population, additional studies are needed on extended samples.
Influence of Calcium and Nonphytate Phosphorus (NPP) on Meat-Type Quail’s Growth, Carcass Features, and Tibia Indices
Authors: Al-Ghamdi Etab Saleh 
Published: June 2022

This study aimed to evaluate the role of increasing dietary calcium (Ca) and non-phytate phosphorus (NPP) supplementation on the growth, carcass, edible portions, and tibia indicators of growing quail. The current study was conducted in a 3×3 factorial design, for this, 360 1-wk-old quails were haphazardly assigned to nine groups, each group is with three gradual levels of Ca (0.60, 0.90, and 1.20 %) and NPP (0.20, 0.40 and 0.60 %). Each group was divided into five replicates with eight-quail each. Results of the study suggested that except at 2 and 6 weeks of age, dietary Ca level did not exhibit any significant (P > 0.05) impact on body weight. Similarly, in the case of NPP, apart from the live weight at 2 and 3 weeks of age, NPP did not have a significant impact on live body weight. Further, in comparison to the low Ca level, the moderate or high Ca levels have higher values of body weight gain. During all the experiments, dietary Ca, NPP, or their mixtures had no significant (P > 0.05) impact on feed consumption. Similarly, feed conversion rate and carcass metrics were also not affected by the individual or combined application of Ca or NPP supplementation Similarly, dietary intakes of Ca or P did not have any significant effect on the various tibia indicators (P > 0.05). Results of the study can be concluded that the effect of the Ca and NPP levels in Japanese quail diets is lowered and it does not much affect the growth rate, feed utilization, carcass yields, edible components, or tibia indices.
Unmasking communication challenges with personal protective equipment amid the COVID-19 apocalypse
Authors: Yadav Anita , Baghel Jyoti , Prakash Avinash , Rawat Rajneesh 
Published: June 2022

The ongoing COVID-19 pandemic has dramatically changed our lives and health care system too. According to World Health Organisation (WHO), there have been 164,523,894 confirmed cases of COVID-19 including 3,412,032 deaths in the world (20 May 2021). This unprecedented public health emergency has affected both patients and clinicians experience regarding traditional face-to-face consultations. Amongst the most pressing of these challenges is the requirement to wear mandated personal protective equipment (PPE) which includes gloves, gowns, shoe covers, head covers, masks, respirators, eye protection, face shields, and goggles. These protective gear helps in preventing the transmission of the COVID-19 virus to both health professionals and the patients.
Comparison of Female and Male Batocera lineolata (Coleoptera: Cerambycidae) Adults with a Combination of Morphological and Mitochondrial DNA Analysis
Authors: Mei Zengxia , Li Jianqing , Yang Jie 
Published: June 2022

Abstract
Morphological and genetic characters of male and female adults of Batocera lineolata Chevrolat were studied to determine intraspecific sex differences. Morphologically, the 9th and 10th segments of the antennae of male adults have odontoid processes that the female lacks. The longitudinal stripes of each abdominal segment of female adults appear to be connected between each adjacent segment, but those of the male do not appear continuous. Female adults also have a narrow V-shaped longitudinal groove in the 5th abdominal segment, whereas males do not. Amplification of the mitochondrial cytochrome c oxidase subunit I gene, cytochrome c oxidase subunit II gene, cytochrome b gene, and ribosomal 16S rRNA gene of four mitochondrial DNA showed sequences that differed between male and female adults. The similarity of the four genes between male and female adults is 98.7%, 99.1%, 98.4%, and 98.8%, respectively. The A+T contents of the four genes in female adults were all higher than in male adults. The difference in content of A+T versus C+G base pairs in female adults was higher than in males. This method of combined morphological and genetic analysis appears to be an accurate and straightforward tool for distinguishing male and female adults of B. lineolata.
Arthropod Associations Show Naturalization with Non-Native Quercus Species in the Georgia Piedmont
Authors: Lampert Evan C. , Cylkowski Z. Ren , McDonough Katie A. , Young Collin R. 
Published: June 2022

Abstract
Native plants may coevolve with native arthropods and may be associated with greater arthropod diversity than non-native plants. Thompson Mills Forest, a state arboretum owned by the University of Georgia and located in Braselton, GA, is home to a variety of oak (Quercus L., Fagacaeae) species, both native and non-native to Georgia. Arthropods were sampled from 20 trees belonging to 12 species, 8 native and 4 non-native, using beat sheets for 10 consecutive weeks in 2018. More than 500 arthropods were collected, with Coleoptera, Araneae, and Psocodea comprising more than 70% of the arthropods collected. Neither abundance nor Shannon index varied among trees of native or non-native origin or among tree species, although both variables peaked during the middle of the sampling period. Multivariate analyses showed similar arthropod communities were associated with native and non-native oaks. The results suggest that non-native plants may naturalize and, if so, may interact with arthropod communities in similar ways as native congeners. Further research into the long-term ecological interactions with non-native plants is recommended.
High Degree of Parasitemia Induces Placental Hypoxia and Low Birth Weight
Authors: Indriana Nurfianti , Rahmah Zainabur , Milliana Alvi 
Published: June 2022

Placental malaria causes low fetal weight associated with infiltration of monocytes and parasites in the placenta resulting in placental hypoxia. Hypoxia is characterized by HIF expression. HIF-1α expression responds early to the occurrence of hypoxia (<24 hours) and HIF-2α promotes chronic hypoxia (>24 hours). There were two groups in this study, namely the control group (10 pregnant mice without Plasmodium berghei infection) and the treatment group (10 pregnant mice infected with Plasmodium berghei). Pregnant mice were operated on on the 18th day after mating. The degree of parasitemia was measured by Giemsa staining. Expression of HIF-1α and HIF-2α in placental tissue was measured by immunohistochemistry. Results by paired t test, HIF-1α expression in the placental tissue in the treatment group was higher than the control group (p=0.02), HIF-2α expression in the placental tissue was higher in the treatment group than in the control group (0, 01) the fetal weight in the treatment group was lower than in the control group (p=0.01). By using SEM analysis, the degree of parasitemia caused high expression of HIF-1α in placental tissue (tcount = 4.625, ttable = 1.96). High expression of HIF-2α in placental tissue (tcount = 2.672 ttable = 1.96). The degree of parasitemia causes low fetal weight (tcount = 27.764 ttable = 1.96). The results also showed that HIF-1 caused low birth weight (tcount = 2.376 ttable=1.96) also HIF-2α caused low fetal weight (tcount = 4.267 ≥ 1.96). Conclusions the degree of parasitemia causes high expression of HIF-1α and HIF-2α in placental tissue and low birth fetuses. Expression of HIF-1α and HIF-2 also causes low birth weight.
Keywords: malaria in pregnancy, degree of parasitemia, HIF-1α , HIF-2α , birth weight
Percepción de sobrevivientes de cáncer de mama, de la campaña publicitaria “Ayúdanos a desaparecer el cáncer de mama”
Authors: Rocha-Villanueva Ariana , Arbaiza Francisco , Gallardo-Echenique Eliana 
Published: June 2022

Introducción: Existe una creciente tendencia por parte de las marcas de tratar temas sociales y, en base a ello, los consumidores generan diferentes percepciones. Objetivo: Analizar cómo perciben las mujeres que han superado el cáncer de mama la campaña publicitaria “Ayúdanos a desaparecer el cáncer de mama” de Oncosalud. Metodología: El enfoque fue fenomenológico. Se utilizó la técnica de entrevista semiestructurada, con lo cual se analizaron las percepciones de quince mujeres que superaron esta enfermedad. Resultados: Los resultados indican que las mujeres sobrevivientes al cáncer de mama perciben la publicidad sobre este tema de manera positiva. Ellas exigen que, si la marca va a realizar una campaña sobre un tema tan delicado, el mensaje debe elaborarse de la forma más pulcra posible. Conclusiones: Su difícil experiencia de vida como pacientes oncológicas les otorga una percepción muy particular sobre lo que se debe mostrar tanto en los mensajes audiovisuales como en las redes sociales.
MELATIH KETERAMPILAN PSIKOMOTORIK SISWA MELALUI PENGGUNAAN LEMBAR KERJA SISWA (LKS)
Authors: Miranti Kiki , Rusyadi Ahmad , Fahmi Fahmi 
Published: June 2022

Education is one way to produce capable and skilled human beings. The education curriculum wants students' achievement competencies to meet the cognitive, affective, psychomotor domains in every learning process. However, the community paradigm that uses the cognitive domain as the basis for student success makes most of the education in conventional-based schools that focuses on the cognitive domain only. This makes students' abilities in the psychomotor realm not appear. Psychomotor skills will emerge by inviting students to work actively in learning. One way that teachers can do is to use student worksheets (LKS). This study aims to train students' psychomotor skills using LKS. The results showed that students' psychomotor skills can be trained well if repeated learning is carried out using LKS.Keywords: Psychomotor skills, LKS, students.ABSTRAKPendidikan merupakan salah satu cara untuk menghasilkan manusia yang berkemapuan dan juga berketarampilan. Kurikulum pendidikan menginginkan kompetensi capian siswa memenuhi ranah kognitif, afektif, psikomotorik dalam setiap proses pembelajaran. Akan tetapi, paradigma masyarakat yang menjadikan ranah kognitif sebagai dasar keberhasilan siswa membuat sebagian besar pendidikan di sekolah berbasis konvensional yang menitikberatkan pada ranah kognitif saja. Hal ini menjadikan kemampuan siswa pada ranah psikomotorik tidak muncul. Keterampilan psikomotorik akan muncul dengan mengajak siswa bekerja aktif dalam pembelajaran. Salah satu cara yang dapat dilakukan guru adalah dengan menggunakan lembar kerja siswa (LKS). Penelitian ini bertujuan untuk melatih keterampilan psikomotorik siswa dengan menggunakan LKS. Hasil penelitian menunjukkan bahwa keterampilan psikomotorik siswa dapat dilatih dengan baik jika dilakukan pembelajaran berulang-ulang menggunakan LKS.Kata kunci: Keterampilan psikomotorik, LKS, siswa.