bluuebunny/crossref_metadata_2025_split huggingface dataset:
Benefits of a laparoscopic approach for second colorectal resection after colectomy or proctectomy
Authors: Nozawa Hiroaki , Sasaki Kazuhito , Emoto Shigenobu , Murono Koji , Yokoyama Yuichiro , Sonoda Hirofumi , Nagai Yuzo , Abe Shinya , Ishihara Soichiro 
Published: October 2022

Abstract
Background: Alaparoscopic approach generally provides several benefits in patients who undergo colon or rectal surgery without jeopardizing oncological outcomes. However, there is a paucity of studies on comparative outcomes of laparoscopic versus open approaches for second primary colorectal lesions after colectomy or proctectomy.
Methods: From patients with colorectal disease who underwent surgery between 2008 and 2021 at our hospital, we collected 73 consecutive patients who had previous colorectal surgery for this retrospective study. Based on the second surgery approach (laparoscopic or open), patients were classified into the Lap (n=38) or Op group (n=35). Patients’ baseline data and perioperative and postoperative outcomes were compared between the two groups.
Results: Four patients (11%) of the Lap group needed conversion to laparotomy. The intraoperative blood loss was lower in the Lap group than the Op group (median: 50 ml vs 210 ml, p=0.0003). The time to first bowel movement was shorter in the Lap group than the Op group (median: 2.7 days vs 3.5 days, p=0.004). The operative time, frequencies of postoperative morbidities, andoverall survival did not differ between the two groups.
Conclusion: Laparoscopic surgery appeared feasible and beneficial for selected patients undergoing second colorectal resection after colectomy or proctectomy regarding blood loss and bowel function recovery without affecting other outcomes.
Body Mass Index and Risk of Internal Knee Derangement: A Mendelian Randomization Study
Authors: Cai Kaishen , Xiong Binglang , Fan Yinuo , Lai Qizhong , Lin Tianye , Chen Minghai , Liang Yupeng , Fang Hanjun , Zhou Chi , Zhang Qingwen , Chen Zhenqiu 
Published: October 2022

Abstract
Background
Traditional observational studies have found an increased risk of internal knee derangement (IKD) associated with higher body mass index (BMI). Here, we hypothesized that BMI and the risk of IKD have a causal relationship, and that high BMI is more likely to suffer from IKD.
Method
By reading the results of previous studies, we can assume that high BMI can increase the risk of IKD. The instrumental variables of BMI were obtained from the GIANT GWAS meta-analysis, which included approximately 700,000 individuals of European descent (n = 681,275). The IKD genetic data from IEU database, comprising 16,380,251 SNPs of European population. We performed MR analysis mainly by inverse-variance weighted (IVW), MR-Egger, Weighted median. In order to test the robustness of the correlation, we further conducted sensitivity analysis through Cochran’s Q test, MR-Egger intercept test and leave-one-out analysis.
Results
Genetic predisposition to higher BMI by 1 SD (SD = 4.8kg/m2) was associated with 49% higher risk of IKD (OR = 1.491; [95%CI: 1.373–1.619]; p = 1.932e-21༜0.05). Sensitivity analysis was consistent with causal interpretation, which shows that there is unlikely to be a major bias in genetic pleiotropy.
Conclusions
Our findings indicated that high BMI predicted by genes exerts a causal effect on increasing the risk of IKD. Further research is required to unravel the mechanism of BMI in IKD prevention.
Experimental Study on the Influence of Curing Conditions on the Mechanical Performance of MSWI-BA
Authors: Zhao Yao , Xu Fengchi 
Published: October 2022

Abstract
In this study, three groups of municipal solid waste incinerated-bottom ash (MSWI-BA) with different particle sizes (1.18–2.36 mm; 2.36–4.75 mm; 4.75–9.5 mm) were separately treated under natural dry, half-wet, and wet condition, to investigate the possibility of their mechanical performance. The strength of MSWI-BA was periodicity tested throughout the crushing value test. The change of microstructure and mineral components over curing time were separately analyzed via scanning electron microscopy-energy dispersive spectroscopy (SEM-EDS) and X-ray diffraction (XRD). The results show that the highest strength of MSWI-BA is obtained under half-wet curing condition. The strength development of MSWI-BA is attributed to the formation of hydration products of calcium silicate hydrate (C-S-H) and the increase in well-crystallized minerals of CaCO3. In addition, the results of the indoor long-term immersion test shows that the heavy metal leached concentrations of MSWI-BA are far below the limited values in Chinese standard (GB 5085), confirming the safety of using MSWI-BA as road construction material from the environmental perspective.
Prospective study on the organization and efficiency of online journal club
Authors: Burlov Nikita , Baranovskii Matvei , Burlova Elizaveta , Khrykov Gleb 
Published: October 2022

Abstract
Background.
Interest in journal clubs is still high. All authors report positive results on subjective parameters. But objective assessments of effectiveness are limited and contradictory. The aim of this study is to share our experience and the effectiveness of the journal club.
Methods.
The prospective cohort study. Our Journal club is held online. To become a member, a person needs to go through 3 steps (application form, tests, interview). Each meeting is conducted online using the Zoom client. The date, time and specialty are chosen by voting in the Telegram channel. The meetings are held in a discussion format. During each samples participants were also tested in EBM and statistics (experimental groups), as well as the contestants (control group).
Results.
Now there were 25 members in the JC. During the year there were 21 meetings. As for the 2nd sample, experimental group had better test results (p unadjusted = 0.032, p adjusted = 0.212). Then, regarding the 3rd sample the outcomes did not differ between the groups.
Conclusion.
The subjective results match the data from other studies. Objective assessments continue to be contradictory. The main limitations may be biases. Additional research is required to help better develop the methodology of organizing and evaluating the effectiveness of journal clubs.
Different Femoral Tunnel Placement in Posterior Cruciate ligament reconstruction: A finite element Analysis
Authors: Wang Bing , Ye Yongjie , Yao Long , Wei Ancheng , Huang Xin , Wang Zhiqiang , Yu Xiaojun 
Published: October 2022

Abstract
Background
At present, there is no consensus on the optimal biomechanical method for PCL reconstruction, and the “critical corner” that is produced by the femoral tunnel is currently considered to be one of the main reasons for PCL failure. Thus, the purpose of this study was to identify one or several different tunnels of the femur, thereby reducing the influence of the "critical corner" without reducing the posterior stability of the knee.
Methods
CT and MRI data of the knee joint of a healthy adult man were collected, and computer-related software was used to reconstruct the finite element model of the knee joint, to provide different properties to different materials and to allow for the performance of a finite element analysis of the reconstructed model. The position of the femoral tunnel was positioned and partitioned according to anatomical posture, and three areas were divided (the antero-proximal region, the antero-distal region and the posterior region). In addition, we applied a posterior tibial load of 134 N to the reconstructed model, recorded and compared different tunnels of the femur, conducted peak stress at the flexion of the knee joint of 0°, 30°, 60° and 90°, and elicited the displacement of the proximal tibia.
Results
Among the 20 different femoral tunnels, the graft peak stress was lower in tunnels 4, 12 and 18 than in the PCL anatomical footpath tunnel 13, especially at high flexion angles (60° and 90°). These three tunnels did not increase the posterior displacement of the proximal tibia compared with the anatomical footpath tunnel 13.
Conclusion
In summary, among the options for PCL reconstruction of the femoral tunnel, the tunnels located 5 mm distal to the footprint and 5 mm anterior to the footprint could reduce the peak stress of the graft; additionally, it may reduce the "critical corner" and was shown to not reduce the posterior stability of the knee joint.
Neuroprotective effect of a multi strain probiotic mixture in SOD1G93A mice Through reducing SOD1 aggregation and targeting the microbe-gut-brain axis
Authors: Xin Zikai , Xin Cheng , Huo Jia , Liu Qi , Dong Hui , Li Rui , Liu Yaling 
Published: October 2022

Abstract
Amyotrophic lateral sclerosis is a devastating neurodegenerative disease characterized by the formation of intracellular protein aggregations and the selective loss of motor neurons. Inflammatory response imbalance was considered to be a risk factor and disease-modifier and involved in the regulation of abnormal protein aggregation in ALS disease. The “microbiota-gut-brain axis” is a bidirectional communication system, which has been shown play some regulatory role in neuroinflammation and abnormal protein aggregation of neurodegenerative disorders. But whether probiotics can exert effects on ALS disease through “microbiota-gut-brain axis” is not clear. In our present study, we first report on superoxide dismutase 1-positive aggregates in intestinal myenteric neurons of SOD1G93A mice. This phenomenon was accompanied by structural disorder of myenteric neurons and enteric glial cells, impaired barrier function and overactivated pro-inflammatory response in intestine. This pathological change is different in colon and ileum, suggesting that it may be related to the difference of microbiota in their lumen. Oral administration of a multi-strain probiotic mixture containing Lactobacillus acidophilus, Bifidobacterium longum and Enterococcus faecalis not only improved the gut barrier function and pro-inflammatory response of spinal cord and intestine but also reduced aberrant SOD1 aggregation in myenteric neurons and spinal cord. This effect is accompanied by the alteration of gut microbiota composition and the increased level of short-chain fatty acids. Together, these findings might imply a potential benefit of microbiota-gut-brain axis axis-based therapy in ALS.
STIFMap employs a convolutional neural network to reveal spatial mechanical heterogeneity and tension-dependent activation of an epithelial to mesenchymal transition within human breast cancers
Authors: Weaver Valerie , Stashko Connor , Hayward Mary-Kate , Northey Jason , Pearson Neil , Ironside Alastair , Lakins Johnathon , Goyette Marie-Anne , Mayo Lakyn , Russnes Hege , Hwang E , Kutys Matthew , Polyak Kornelia 
Published: October 2022

Abstract
Intratumor heterogeneity in breast cancer associates with poor patient outcome. Tissue fibrosis and stromal stiffening accompany breast cancer development and associate with the aggressiveness of human breast cancer subtypes. Whether human breast cancers demonstrate stiffness heterogeneity, and if this is linked to breast tumor aggression remains unclear. To answer these questions, we developed a spatial method to measure the stiffness heterogeneity in human breast tumor tissues that also quantifies the local stromal stiffness each cell experiences and permits correlation with biomarkers of tumor aggression. Here, we present Spatially Transformed Inferential Force Maps (STIFMaps) to predict the elasticity across whole tissue sections with micron-resolution. The method exploits computer vision to precisely automate AFM indentation and then uses a trained convolutional neural network to predict matrix elasticity using collagen morphological features and ground truth AFM data. Because STIFMaps is compatible with biomarker staining we used the approach to register high-elasticity regions within sections of human breast tumors with markers of mechanical activation and an epithelial to mesenchymal transition (EMT) that associated with tumor aggression. The findings herein highlight the utility of STIFMaps for assessing the mechanical heterogeneity of human breast tissues across length scales from single cells to whole tissues. The method also reveals, for the first time, a direct association between stromal stiffness and EMT, thereby implicating stromal stiffness as a driver of human breast cancer aggression.
Network Contagion of COVID-19 on US Industries
Authors: Levin Michael 
Published: October 2022

Abstract
The applications of Network Science have been limited in finance, but recently Zhu et. al (2016) have created a methodology in which co-movements between a given industry and the overall stock market can be represented by nodes and transitions between these movement states can be represented as edges. This modeling approach creates network structures that provide information on the susceptibility of markets to contagious risk that can be studied with network methods. This paper builds on this methodology to study the effect of the COVID-19 pandemic on contagious financial risk across industrial sectors. I propose a novel metric to measure an industry’s susceptibility to contagion at a point in time. I apply this metric to a sample of U.S. industrial ETFs before and after the onset of the pandemic. My results suggest that COVID-19 led to increases in the susceptibility to contagious risk across all sectors.
Assessing the feasibility, fidelity and acceptability of a behaviour change intervention to improve tractor safety on farms: Protocol for the BeSafe tractor safety feasibility study
Authors: Surendran Aswathi , McSharry Jenny , Bligh Francis , McNamara John , Meredith David , O'Hora Denis 
Published: October 2022

Abstract
Background: In Ireland, the agriculture sector reports the highest number of fatalities even though farmers constitute only 6% of the working population. Tractor-related behaviours are implicated in 55% of all vehicle work-related fatalities and 25% of reported injuries, and many of these occur in farmyards. There is limited research on the feasibility and acceptability of behaviour change interventions to improve tractor safety. Target behaviours that promotes safe operation in farmyards, determining and addressing blind-spots of tractors, were identified, and an intervention was developed following the Behaviour Change Wheel Approach. The objective of the study is to examine the feasibility, fidelity and acceptability of a behaviour change intervention to enhance the safe operation of tractors in farmyards with a particular focus on tractor blind spots.
Method: A single group, pre-post feasibility study will be undertaken. Approximately 16 farmers from four major farm types will be recruited for the study between August and September 2022. The intervention involves an in-person demo session, facilitated discussion and personalised safety training procedure with safety goals. Data will be collected from participants at baseline (3-10 days before the intervention), during the intervention, and the follow-up session (7-30 days after the intervention). Quantitative data will be collected through a pre-intervention interview and feedback surveys. A pre and post-intervention qualitative interview will also be conducted with the participants and will be supplemented with qualitative data from recruitment logs, observational memos and logs and feedback from recruiters. Evaluation of the feasibility, acceptability and fidelity of the intervention will be guided by a pre-determined feasibility checklist, fidelity framework and theoretical framework of acceptability, respectively. Interviews will be analysed using the content analysis
Discussion: The current study can determine the feasibility and fidelity of delivering a systematic, theoretically driven, tailored behaviour change intervention. It will also assess whether the intervention, its ingredients, and delivery are acceptable to the farming population. This study will also inform the development of a future larger trial to test the effectiveness of the intervention.
Trial registration: ISRCTN Identifier: ISRCTN22219089. Date applied 29th July 2022
Identification of SNHG16 and Its Derived Tumor Immune Gene Signatures for Predicting Prognosis and Efficacy of Immunotherapy in Bladder Cancer
Authors: Li Yu-chen , Zhu Yu-yan , Fu Yang , Guo Dan-yang , Yu Meng , Li Ze-liang , Shi Du , Kong Chui-ze Z. 
Published: October 2022

Abstract
Background

In the era of individualized therapy,there is a great need to incorporate lncRNAs into preclinical models to develop prognostic or therapeutic biomarkers.We sought to apply the tumor immune-associated lncRNA – SNHG16 to develop and validate a predictive model constructed from SNHG16 and associated immune gene signatures in BC patients obtained from independent public datasets and clinical internal cohorts, to assess the benefit of immune checkpoint inhibitors treatment and the prognosis in BC patients.

Materials and methods

A novel immune-related and independent predictive model was developed for prognosis and immunotherapeutic evaluation of bladder cancer, based on the identification and analysis of the immune-related SNHG16. Based on the training (TCGA-BLCA) and external validation datasets, the SNHG16-associated immune gene signature was applied to classify BC patients into low- and high-risk groups. Cell proliferation assay and Transwell assay were used to detect the function of related genes.

Results

There were significant differences in prognosis and response to immunotherapy among patients in the different risk groups. Univariate and multivariate analyses confirmed the SNHG16-associated immune gene signature to be an independent predictor of BC prognosis. In addition,in vitro functional assay data confirmed the cancer biological function of SNHG16 and its associated immune signature genes.

Conclusions

Immune-associated lncRNA-SNHG16 and its associated immune gene signatures are reliable tools for predicting BC prognosis and response to immunotherapy and may provide valuable insights for deciding the treatment for BC. Further, the model will provide useful guidance for clinical judgment and personalized regimen-selection for immunotherapy of bladder tumors.
Genome-wide association study reveals candidate genes for traits related to meat quality in Colombian Creole hair sheep
Authors: Revelo Herman Alberto , López-Alvarez Diana , Palacios Yineth , Vergara Oscar David , Bustamante Moris , Ariza Manual Fernando , Castro Susan Lorena , Ortiz Yurani , Álvarez Luz Angela 
Published: October 2022

Abstract
Genome-wide association studies (GWAS) allow identifying genomic regions related to traits of economic importance in animals of zootechnical interest.
Objective: To conduct a genome-wide association study on muscle growth traits using Illumina OvineSNPs50 BeadChip array.
Methods: We analyzed SNP (single-nucleotide polymorphism) data to conduct a GWAS for pH and water-holding capacity (WHC) traits in the Longissimus dorsi (LD) muscle in 167 Creole hair sheep of 12 months old belonging to Pelibuey (CHSP, n=60), Ethiopian (CHSE, n=44), and Sudan (CHSS, n=63) breeds. We measured pH and WHC after seven days of maturation. Genotype data were obtained from an Illumina OvineSNP50 BeadChip array. The GWAS was done using a mixed linear model (MLMA) and based on the Ovis aries v3.1 genome.
Results: CHSE showed the lowest meat juice release and, consequently, the highest water-holding capacity (WHC=30.6±0.1), suggesting that this breed has better performance in the meat industry compared with CHSS (WHC=41.7±0.1) and CHSP (WHC=36.8±0.1). We obtained 11 candidate genes associated with WHC (ELOVL2, ARAP2, LOC101102527, SHOC2, AIPL1, CSRNP3, IFRD, KDM8, NANS, DAPK1, IBN2, TPM2 ). Particularly, ELOVL2, ARAP2, IBN2, and TPM2 genes are involved in muscle contraction and fatty acid composition in sheep.
Conclusion: In this study, we generated a baseline for GWAS related to meat quality traits in Colombian Creole hair sheep, that can be used for future genomic selection plans.
Is Ventricular Lavage a Novel Treatment of Neonatal Posthemorrhagic Hydrocephalus? A Meta analysis
Authors: Parenrengi Muhammad Arifin , Ranuh I. G. M Aswin R. , Suryaningtyas Wihasto 
Published: October 2022

Abstract
Introduction
Intraventricular hemorrhage (IVH) may produce obliterative arachnoiditis, which disrupts the flow and absorption of cerebrospinal fluid (CSF), resulting in posthemorrhagic hydrocephalus (PHH). PHH gives a high risk of neurofunctional impairment.
Ventricular lavage is the treatment of choice for PHH in neonates with IVH for decades. It’s developing with the combination of fibrinolytic therapy also called drainage, irrigation and fibrinolytic therapy (DRIFT), and with the using of neuroendoscopic apparatus also called neuroendoscopic lavage (NEL).
Methods
This review is a meta-analysis using the PRISMA method guideline, including the clinical studies comparing ventricular lavage (VL) with standard treatment of PHH between 2000 and 2021.
Results
VL group reduce the shunt dependency compared to standard treatment (OR = 0.22; 95CI 0.05 to 0.97; p = 0.05). VL group has less infection risk compared to the standard treatment group (RR = 0.20; 95CI 0.07 to 0.59; p < 0.05). The severe neurofunctional outcome is similar between the two groups (OR = 0.99; 95CI 0.13 to 7.23; p = 0.99). The early approach treatment group may give better neurofunctional outcome compared to the late approach (OR = 0.14; 95CI 0.06 to 0.35; p < 0.05).
Conclusion
VL reduce the shunt dependency on the PHH, decreasing the shunt’s related infection rate. The early ventricular lavage may give benefit for the neurocognitive outcome.
Mammalian Diversity, Abundance and Habitat Preferences in Godebe National Park, Amhara Regional State, Ethiopia
Authors: Melese Getahun Tassew , Taju Muhabaw 
Published: October 2022

Abstract
In Ethiopia, the number of protected areas is increasing mainly to conserve the biodiversity resources facing anthropogenic threats and thereby mitigate the ever-changing temperature change and its effects. The study was conducted in Godebe Park with the target of assessing the variety, distribution, abundance, and habitat preferences of untamed mammalian species within the park. A stratified sampling technique was wont to collect data using line transect across four major habitat types. The information were analysed employing a speed sheet and R software version 4.2. Fifteen mammalian species were identified by direct sighting and indirect indicators under five orders and ten families. Carnivora was the family richest, whereas Bovidae was the species’ richest family. Combretum - Terminalia Woodland was the species richest with the best diversity (H′ = 1.98) and evenness (J = 0.73). Savana was the poorest in species richness whereas the smallest amount of diversity and evenness were recorded within the Riverine habitat (H′ = 1.15) and (J = 0.42). The best similarity in species occurrences was between Combretum - Terminalia Woodland and Riverine habitats(S = 0.75) and therefore the least similarity was between Combretum - Terminalia Woodland and Savana (0.52). Cercopithecus aethiops were the foremost abundant (relative abundance = 46.22%) followed by Hystrix cristata (17.78%) whereas the smallest amount abundant was Erythrocebus patas (0.44%). The National park is endowed with moderate wild mammalian diversity distributed all told major habitat types. The foremost preferable habitat type was the riverine forest with the foremost abundant of Cercopithecus aethiops. The National park is surrounded by resettlements and commercial farming harbouring ecological threats. A way of ownership should be developed by stakeholders and officials so the threats to the park should be removed.