bluuebunny/crossref_metadata_2025_split huggingface dataset:
Targeting transcription in heart failure via CDK7/12/13 inhibition
Authors: Hsu Austin , Duan Qiming , Day Daniel S. , Luo Xin , McMahon Sarah , Huang Yu , Feldman Zachary B. , Jiang Zhen , Zhang Tinghu , Liang Yanke , Alexanian Michael , Padmanabhan Arun , Brown Jonathan D. , Lin Charles Y. , Gray Nathanael S. , Young Richard A. , Bruneau Benoit G. , Haldar Saptarsi M. 
Published: July 2022

AbstractHeart failure with reduced ejection fraction (HFrEF) is associated with high mortality, highlighting an urgent need for new therapeutic strategies. As stress-activated cardiac signaling cascades converge on the nucleus to drive maladaptive gene programs, interdicting pathological transcription is a conceptually attractive approach for HFrEF therapy. Here, we demonstrate that CDK7/12/13 are critical regulators of transcription activation in the heart that can be pharmacologically inhibited to improve HFrEF. CDK7/12/13 inhibition using the first-in-class inhibitor THZ1 or RNAi blocks stress-induced transcription and pathologic hypertrophy in cultured rodent cardiomyocytes. THZ1 potently attenuates adverse cardiac remodeling and HFrEF pathogenesis in mice and blocks cardinal features of disease in human iPSC-derived cardiomyocytes. THZ1 suppresses Pol II enrichment at stress-transactivated cardiac genes and inhibits a specific pathologic gene program in the failing mouse heart. These data identify CDK7/12/13 as druggable regulators of cardiac gene transactivation during disease-related stress, suggesting that HFrEF features a critical dependency on transcription that can be therapeutically exploited.
Aberrant androgen action in prostatic progenitor cells induces oncogenesis and tumor development through IGF1 and Wnt axes
Authors: Kim Won Kyung , Olson Adam W. , Mi Jiaqi , Wang Jinhui , Lee Dong-Hoon , Le Vien , Hiroto Alex , Aldahl Joseph , Nenninger Christian H. , Buckley Alyssa J. , Cardiff Robert , You Sungyong , Sun Zijie 
Published: July 2022

AbstractAndrogen/androgen receptor (AR) signaling pathways are essential for prostate tumorigenesis. However, the fundamental mechanisms underlying the AR functioning as a tumor promoter in inducing prostatic oncogenesis still remain elusive. Here, we demonstrate that a subpopulation of prostatic Osr1 (odd skipped-related 1)-lineage cells functions as tumor progenitors in prostate tumorigenesis. Single cell transcriptomic analyses reveal that aberrant AR activation in these cells elevates insulin-like growth factor 1 (IGF1) signaling pathways and initiates oncogenic transformation. Elevating IGF1 signaling further cumulates Wnt/β-catenin pathways in transformed cells to promote prostate tumor development. Correlations between altered androgen, IGF1, and Wnt/β-catenin signaling are also identified in human prostate cancer samples, uncovering a dynamic regulatory loop initiated by the AR through prostate cancer development. Co-inhibition of androgen and Wnt-signaling pathways significantly represses the growth of AR-positive tumor cells in both ex-vivo and in-vivo, implicating co-targeting therapeutic strategies for these pathways to treat advanced prostate cancer.
Single-droplet surface-enhanced Raman scattering decodes the molecular determinants of liquid-liquid phase separation
Authors: Avni Anamika , Joshi Ashish , Walimbe Anuja , Pattanashetty Swastik G. , Mukhopadhyay Samrat 
Published: July 2022

AbstractBiomolecular condensates formed via liquid-liquid phase separation (LLPS) are involved in a myriad of critical cellular functions and debilitating neurodegenerative diseases. Elucidating the role of intrinsic disorder and conformational heterogeneity of intrinsically disordered proteins/regions (IDPs/IDRs) in these phase-separated membrane-less organelles is crucial to understanding the mechanism of formation and regulation of biomolecular condensates. Here we introduce a unique single-droplet surface-enhanced Raman scattering (SERS) methodology that utilizes surface-engineered, plasmonic, metal nanoparticles to unveil the inner workings of mesoscopic liquid droplets of Fused in Sarcoma (FUS) in the absence and presence of RNA. These highly sensitive measurements offer unprecedented sensitivity to capture the crucial interactions, conformational heterogeneity, and structural distributions within the condensed phase in a droplet-by-droplet manner. Such an ultra-sensitive single-droplet vibrational methodology can serve as a potent tool to decipher the key molecular drivers of biological phase transitions of a wide range of biomolecular condensates involved in physiology and disease.
Datasets of fingertip forces while grasping a handle with unsteady thumb platform
Authors: Rajakumar Banuvathy , SKM Varadhan 
Published: July 2022

AbstractThis article presents the fingertip forces and moments data of the individual fingers and thumb when the thumb was placed on an unsteady platform, when the mass of the handle was systematically increased and when the thumb normal force was restricted while grasping a handle. Further, this article also includes a dataset while the thumb makes vertical movements such as extension (or upward motion) and flexion movement (or downward motion) during the static holding of a handle. An instrumented five-finger prehension handle was designed with a vertical railing on the thumb side. A slider platform was placed over the railing to mount the thumb force sensor. Further, a laser displacement sensor was mounted on top of the handle towards the thumb side to record the displacement of the thumb platform. The dataset includes fingertip forces, orientation of the handle, and the displacement data of thumb platform. This data helps therapists assess the degree of thumb disability, the contribution of ulnar fingers in establishing static equilibrium of a handheld object.
The role of plant functional groups mediating climate impacts on carbon and biodiversity of alpine grasslands
Authors: Vandvik Vigdis , Althuizen Inge H. J. , Jaroszynska Francesca , Krüger Linn C. , Lee Hanna , Goldberg Deborah E. , Klanderud Kari , Olsen Siri L. , Telford Richard J. , Östman Silje A. H. , Busca Sara , Dahle Ingrid J. , Egelkraut Dagmar D. , Geange Sonya R. , Gya Ragnhild , Lynn Josh S. , Meineri Eric , Young Sherry , Halbritter Aud H. 
Published: July 2022

AbstractPlant removal experiments allow assessment of the role of biotic interactions among species or functional groups in community assembly and ecosystem functioning. When replicated along climate gradients, they can assess changes in interactions among species or functional groups with climate. Across twelve sites in the Vestland Climate Grid (VCG) spanning 4 °C in growing season temperature and 2000 mm in mean annual precipitation across boreal and alpine regions of Western Norway, we conducted a fully factorial plant functional group removal experiment (graminoids, forbs, bryophytes). Over six years, we recorded biomass removed, soil microclimate, plant community composition and structure, seedling recruitment, ecosystem carbon fluxes, and reflectance in 384 experimental and control plots. The dataset consists of 5,412 biomass records, 360 species-level biomass records, 1,084,970 soil temperature records, 4,771 soil moisture records, 17,181 plant records covering 206 taxa, 16,656 seedling records, 3,696 ecosystem carbon flux measurements, and 1,244 reflectance measurements. The data can be combined with longer-term climate data and plant population, community, ecosystem, and functional trait data collected within the VCG.
Reading text works better than watching videos to improve acuity in a simulation of artificial vision
Authors: Rassia Katerina Eleonora K. , Moutoussis Konstantinos , Pezaris John S. 
Published: July 2022

AbstractSimulated artificial vision is used in visual prosthesis design to answer questions about device usability. We previously reported a striking increase in equivalent visual acuity with daily use of a simulation of artificial vision in an active task, reading sentences, that required high levels of subject engagement, but passive activities are more likely to dominate post-implant experience. Here, we investigated the longitudinal effects of a passive task, watching videos. Eight subjects used a simulation of a thalamic visual prosthesis with 1000 phosphenes to watch 23 episodes of classic American television in daily, 25-min sessions, for a period of 1 month with interspersed reading tests that quantified reading accuracy and reading speed. For reading accuracy, we found similar dynamics to the early part of the learning process in our previous report, here leading to an improvement in visual acuity of 0.15 ± 0.05 logMAR. For reading speed, however, no change was apparent by the end of training. We found that single reading sessions drove about twice the improvement in acuity of single video sessions despite being only half as long. We conclude that while passive viewing tasks may prove useful for post-implant rehabilitation, active tasks are likely to be preferable.
Identifying potential mechanisms between childhood trauma and the psychological response to the COVID‐19 pandemic in Germany: a longitudinal study
Authors: Rek Stephanie V. , Reinhard Matthias A. , Bühner Markus , Freeman Daniel , Adorjan Kristina , Falkai Peter , Padberg Frank 
Published: July 2022

AbstractChildhood maltreatment (CM) has been associated with adverse psychosocial outcomes during the pandemic, but the underlying mechanisms are unclear. In a prospective online study using baseline and 10-week follow-up data of 391 German participants, we applied multiple mediation analyses to test to what extent COVID-19 perceived stressors mediate the association between CM and later adverse psychosocial outcomes compared to established mediators of rumination and insecure attachment. We also explored the relative importance of different COVID-19 related stressors in predicting adverse psychological trajectories using elastic net regression. Results showed that CM was longitudinally associated with all adverse psychosocial outcome. COVID-19 perceived stressors, rumination, and insecure attachment mediated this relationship and full mediation was observed for the outcomes anxiety, stress and psychological well-being. COVID-19-related concerns about the future was most strongly and consistently associated with adverse psychosocial functioning. These findings provide preliminary evidence that COVID-19 perceived stressors, in particular concerns about the future, may be a key mechanism underlying the development of adverse psychosocial outcomes in individuals with a CM history. Thus, COVID-19 perceived stressors may require a higher priority for prevention and treatment efforts in vulnerable groups. Our results warrant replication in more representative cross-cultural samples.
A dynamic AES cryptosystem based on memristive neural network
Authors: Liu Y. A. , Chen L. , Li X. W. , Liu Y. L. , Hu S. G. , Yu Q. , Chen T. P. , Liu Y. 
Published: July 2022

AbstractThis paper proposes an advanced encryption standard (AES) cryptosystem based on memristive neural network. A memristive chaotic neural network is constructed by using the nonlinear characteristics of a memristor. A chaotic sequence, which is sensitive to initial values and has good random characteristics, is used as the initial key of AES grouping to realize "one-time-one-secret" dynamic encryption. In addition, the Rivest-Shamir-Adleman (RSA) algorithm is applied to encrypt the initial values of the parameters of the memristive neural network. The results show that the proposed algorithm has higher security, a larger key space and stronger robustness than conventional AES. The proposed algorithm can effectively resist initial key-fixed and exhaustive attacks. Furthermore, the impact of device variability on the memristive neural network is analyzed, and a circuit architecture is proposed.
On the generation of realistic synthetic petrographic datasets using a style-based GAN
Authors: Ferreira Ivan , Ochoa Luis , Koeshidayatullah Ardiansyah 
Published: July 2022

AbstractDeep learning architectures have transformed data analytics in geosciences, complementing traditional approaches to geological problems. Although deep learning applications in geosciences show encouraging signs, their potential remains untapped due to limited data availability and the required in-depth knowledge to provide a high-quality labeled dataset. We approached these issues by developing a novel style-based deep generative adversarial network (GAN) model, PetroGAN, to create the first realistic synthetic petrographic datasets across different rock types. PetroGAN adopts the architecture of StyleGAN2 with adaptive discriminator augmentation (ADA) to allow robust replication of statistical and esthetical characteristics and improve the internal variance of petrographic data. In this study, the training dataset consists of > 10,000 thin section images both under plane- and cross-polarized lights. Here, using our proposed novel approach, the model reached a state-of-the-art Fréchet Inception Distance (FID) score of 12.49 for petrographic images. We further observed that the FID values vary with lithology type and image resolution. The generated images were validated through a survey where the participants have various backgrounds and level of expertise in geosciences. The survey established that even a subject matter expert observed the generated images were indistinguishable from real images. This study highlights that GANs are a powerful method for generating realistic synthetic data in geosciences. Moreover, they are a future tool for image self-labeling, reducing the effort in producing big, high-quality labeled geoscience datasets. Furthermore, our study shows that PetroGAN can be applied to other geoscience datasets, opening new research horizons in the application of deep learning to various fields in geosciences, particularly with the presence of limited datasets.
Quasi-dark resonances with antiferromagnetic order in silicon metasurfaces
Authors: Zografopoulos D. C. , Algorri J. F. , López-Higuera J. M. , Hernandez-Figueroa H. E. , Dmitriev V. 
Published: July 2022

AbstractQuasi-dark resonances exhibiting antiferromagnetic order are theoretically investigated in a near-infrared metasurface composed of square slotted rings etched in a thin silicon layer on glass substrate. Access to the quasi-dark mode is achieved by reducing the symmetry of the metasurface according to the findings of a detailed group theory analysis. A thorough finite-element study reveals the key optical properties of the antiferromagnetic order quasi-dark mode, namely resonant wavelengths, quality factors, angular dispersion, and its robustness against optical extinction losses. It is demonstrated that the thickness of the silicon metasurface can adjust the asymmetry degree of the resonant Fano lineshape without affecting substantially its quality factor. Furthermore, tuning of the resonant wavelength can be achieved without significant modification of the Fano lineshape by controlling the angle of incidence of the impinging planewave. Overall, the work presents an all-dielectric, near-infrared metasurface for the excitation of sharp resonances with antiferromagnetic order, which can find use in emerging applications based on this particular configuration of artificial optical magnetism and/or strong field confinement and light-matter interaction.
Endogenous rhythms influence musicians’ and non-musicians’ interpersonal synchrony
Authors: Tranchant Pauline , Scholler Eléonore , Palmer Caroline 
Published: July 2022

AbstractIndividuals display considerable rate differences in the spontaneous production of rhythmic behaviors (such as speech, gait, dance). Temporal precision in rhythmic behavior tends to be highest at individuals’ spontaneous production rates; musically trained partners with similar spontaneous rates show increased synchrony in joint tasks, consistent with predictions based on intrinsic frequencies of coupled oscillators. We address whether partner-specific influences of intrinsic frequencies are evidenced in musically trained and untrained individuals who tapped a familiar melody at a spontaneous (uncued) rate individually. Each individual then synchronized with a partner from the same musicianship group at an initially cued rate that matched the partners’ spontaneous rates. Musically trained partners showed greater synchrony in joint tapping than musically untrained partners. Asynchrony increased in both groups as the partners’ difference in individual spontaneous rates increased, with greater impact for musically untrained pairs. Recurrence quantification analysis confirmed that musically untrained individuals demonstrated greater determinism (less flexibility) in their tapping than musically trained individuals. Furthermore, individuals with greater determinism in solo performances demonstrated reduced synchrony in joint performances. These findings suggest that musicians’ increased temporal flexibility is associated with decreased endogenous constraints on production rate and greater interpersonal synchrony in musical tasks.
Effect of hyperhomocysteinemia on a murine model of smoke-induced pulmonary emphysema
Authors: Nakano Hiroshi , Inoue Sumito , Minegishi Yukihiro , Igarashi Akira , Tokairin Yoshikane , Yamauchi Keiko , Kimura Tomomi , Nishiwaki Michiko , Nemoto Takako , Otaki Yoichiro , Sato Masamichi , Sato Kento , Machida Hiroyoshi , Yang Sujeong , Murano Hiroaki , Watanabe Masafumi , Shibata Yoko 
Published: July 2022

AbstractHyperhomocysteinemia was reported to enhance endoplasmic reticulum (ER) stress and subsequent apoptosis in several cells. However, the precise mechanisms of smoking susceptibility associated with hyperhomocysteinemia has not been fully elucidated. This study included 7- to 9-week-old C57BL6 male mice induced with hyperhomocysteinemia and were exposed to cigarette smoke (CS). A549 cells (human alveolar epithelial cell line) were cultured with homocysteine and were exposed to cigarette smoke extract (CSE) to observe cell viability and expression of proteins related to the ER stress. After 6 months of CS exposure, pulmonary emphysema was more severely induced in the group under the condition of hyperhomocysteinemia compared to that in the control group. The apoptotic A549 cells increased as homocysteine concentration increased and that was enhanced by CSE. Protein expression levels of ER stress markers were significantly increased after simultaneous stimulation. Notably, vitamin B12 and folate supplementation improved ER stress after simultaneous stimulation of A549 cells. In this study, we showed that hyperhomocysteinemia exacerbates CS exposure-induced emphysema in mice, suggesting that hyperhomocysteinemia and CS stimulation enhance ER stress and subsequent induced apoptosis in alveolar epithelial cells. It was suggested that there is a synergistic effect between homocysteine and CS.
Assessing temporal correlation in environmental risk factors to design efficient area-specific COVID-19 regulations: Delhi based case study
Authors: Chaudhary Vishal , Bhadola Pradeep , Kaushik Ajeet , Khalid Mohammad , Furukawa Hidemitsu , Khosla Ajit 
Published: July 2022

AbstractAmid ongoing devastation due to Serve-Acute-Respiratory-Coronavirus2 (SARS-CoV-2), the global spatial and temporal variation in the pandemic spread has strongly anticipated the requirement of designing area-specific preventive strategies based on geographic and meteorological state-of-affairs. Epidemiological and regression models have strongly projected particulate matter (PM) as leading environmental-risk factor for the COVID-19 outbreak. Understanding the role of secondary environmental-factors like ammonia (NH3) and relative humidity (RH), latency of missing data structuring, monotonous correlation remains obstacles to scheme conclusive outcomes. We mapped hotspots of airborne PM2.5, PM10, NH3, and RH concentrations, and COVID-19 cases and mortalities for January, 2021-July,2021 from combined data of 17 ground-monitoring stations across Delhi. Spearmen and Pearson coefficient correlation show strong association (p-value < 0.001) of COVID-19 cases and mortalities with PM2.5 (r > 0.60) and PM10 (r > 0.40), respectively. Interestingly, the COVID-19 spread shows significant dependence on RH (r > 0.5) and NH3 (r = 0.4), anticipating their potential role in SARS-CoV-2 outbreak. We found systematic lockdown as a successful measure in combatting SARS-CoV-2 outbreak. These outcomes strongly demonstrate regional and temporal differences in COVID-19 severity with environmental-risk factors. The study lays the groundwork for designing and implementing regulatory strategies, and proper urban and transportation planning based on area-specific environmental conditions to control future infectious public health emergencies.
Comparison of two different contrast sensitivity devices in young adults with normal visual acuity with or without refractive surgery
Authors: Jung Hyunjean , Han Sung Uk , Kim Sangyeop , Ahn Hyunmin , Jun Ikhyun , Lee Hyung Keun , Seo Kyoung Yul , Kim Tae-im 
Published: July 2022

AbstractThis study investigated the reliability and correlation of two contrast sensitivity test (CST) devices in young adults with normal visual acuity, with or without refractive surgery. 57 patients aged 20–39 years who received both manual (OPTEC-6500) and automated CST (CGT-2000) examinations from June 19 to July 24, 2021 were retrospectively enrolled. Patients with corrected visual acuity under 20/20 or history of ocular surgery other than refractive surgery were excluded. 82 eyes of 41 patients (40 eyes with and 42 without history of refractive surgery) were enrolled. Mean time taken to complete each examination was 396.4 ± 20.4 and 286.8 ± 2.3 s using manual and automated CST, respectively (P < 0.001). Patients who underwent refractive surgery had significantly decreased area under the log contrast sensitivity formula (AULCSF) in mesopic compared with photopic conditions in automated CST examinations (AULCSF difference 0.415 vs. 0.323 in patients with and without refractive surgery, P < 0.001), but there was no significant difference in manual CST examinations. Patients who reported decreased subjective night vision had significantly decreased AULCSF in automated CST examinations, but there was no significant difference in manual CST examinations. Compared with manual CST, automated CST was quicker and correlated well with decrease in subjective night vision.
Vav2 is a novel APP-interacting protein that regulates APP protein level
Authors: Zhang Youjia , Yang Xiaxin , Liu Yongrui , Ge Liang , Wang Jiarong , Sun Xiulian , Wu Bo , Wang Junfeng 
Published: July 2022

AbstractAmyloid precursor protein (APP) is a transmembrane protein that plays critical role in the pathogenesis of Alzheimer's disease (AD). It is also involved in many types of cancers. Increasing evidence has shown that the tyrosine phosphorylation site Y682 in the intracellular tail of APP is crucial for APP function. Here, we report that Vav2, a guanine nucleotide exchange factor (GEF) for Rho family GTPase, is a novel interaction partner of APP. We found that Vav2-SH2 domain was able to bind directly to the Y682-phosphorylated intracellular tail of APP through isothermal titration calorimetry and NMR titrating experiments. The crystal structure of Vav2-SH2 in complex with an APP-derived phosphopeptide was determined to understand the structural basis of this recognition specificity. The interaction of APP and Vav2 in a full-length manner was further confirmed in cells by GST pull-down, co-immunoprecipitation and immunofluorescence staining experiments. In addition, we found overexpression of Vav2 could inhibit APP degradation and markedly increase the protein levels of APP and its cleavage productions in 20E2 cells, and this function of Vav2 required a functional SH2 domain.