bluuebunny/crossref_metadata_2025_split huggingface dataset:
Transforming Dyes into Fluorophores: Exciton‐Induced Emission with Chain‐like Oligo‐BODIPY Superstructures
Authors: Patalag Lukas J. , Hoche Joscha , Mitric Roland , Werz Daniel B. , Feringa Ben L. 
Published: March 2022

AbstractHerein we present a systematic study demonstrating to which extent exciton formation can amplify fluorescence based on a series of ethylene‐bridged oligo‐BODIPYs. A set of non‐ and weakly fluorescent BODIPY motifs was selected and transformed into discrete, chain‐like oligomers by linkage via a flexible ethylene tether. The prepared superstructures constitute excitonically active entities with non‐conjugated, Coulomb‐coupled oscillators. The non‐radiative deactivation channels of Internal Conversion (IC), also combined with an upstream reductive Photoelectron Transfer (rPET) and Intersystem Crossing (ISC) were addressed at the monomeric state and the evolution of fluorescence and (non‐)radiative decay rates studied along the oligomeric series. We demonstrate that a “masked” fluorescence can be fully reactivated irrespective of the imposed conformational rigidity. This work challenges the paradigm that a collective fluorescence enhancement is limited to sterically induced motional restrictions.
Coordination‐Controlled Nickel‐Catalyzed Benzylic Allylation of Unactivated Electron‐Deficient Heterocycles
Authors: Zhang Pengpeng , Wang Jin , Robertson Zoe R. , Newhouse Timothy R. 
Published: March 2022

AbstractHeterocycles are widespread in pharmaceuticals but methods for their transition metal‐catalyzed functionalization remain limited. This report describes a general, mild, and effective nickel‐catalyzed benzylic allylation and benzylation of 14 types of heterocyclic aromatic compounds, including pyridines, pyrazines, pyrimidines, pyridazines, triazines, benzimidazoles, oxazoles, thiazoles, as well as 3,3‐dimethyl‐indoles. The exquisite selectivity for benzylic sites at the 2‐position is hypothesized to be controlled by coordination of a heterocyclic nitrogen to Zn(TMP)2 subverting generally presumed pKa’s of benzylic protons. Furthermore, the broad range of heterocyclic substrates, the diversity of electrophiles, and excellent functional group compatibility suggest its future application to synthesis of complex molecules and library diversification in drug discovery.
Tandem Macrolactone Synthesis: Total Synthesis of (−)‐Exiguolide by a Macrocyclization/Transannular Pyran Cyclization Strategy
Authors: Mizukami Daichi , Iio Kei , Oda Mami , Onodera Yu , Fuwa Haruhiko 
Published: March 2022

AbstractTetrahydropyran‐containing macrolactones were synthesized by integrating Meyer–Schuster rearrangement, macrocyclic ring‐closing metathesis, and transannular oxa‐Michael addition under gold and ruthenium catalysis. Single‐step access to a variety of 14‐ to 20‐membered macrolactones containing a tetrahydropyran ring was possible from readily available linear precursors in good yields and with moderate to excellent diastereoselectivity. A 13‐step synthesis of (−)‐exiguolide, an anticancer marine macrolide, showcased the feasibility of our tandem reaction sequence for macrolactone synthesis and also demonstrated the power of transannular reactions for rapid assembly of the tetrahydropyran rings of the target natural product.
Perylene‐Based Linear Nonalternant Nanoribbons with Bright Emission and Ambipolar Redox Behavior
Authors: Wang Yanpei , Huang Yulin , Huang Tingting , Zhang Jun , Luo Teng , Ni Yong , Li Bo , Xie Sheng , Zeng Zebing 
Published: March 2022

AbstractHere we report stepwise solution‐synthesis of linear nonalternant nanoribbons (NNRs), featuring pentagonal ringsperi‐fused onto the repeating perylene unit. The X‐ray single‐crystal structures demonstrated their π‐backbones as a twisted ribbon, with the longest crystalline length of the nanoribbon up to 3.9 nm.NNRsexhibited an orange to deep‐red photoluminescence even under the room light, with absolute ΦFup to 82 %, most likely due to ring‐strain induced molecular stiffness. Benefiting from the enlarged size and the antiaromatic character of pentagons, all ofNNRspossessed ambipolar redox properties, especially for longer nanoribbons showing multiple reversible reductions and oxidations. In addition, experimental and theoretical results indicated a ground state open‐shell singlet diradicaloid for the dication of longerNNRs. Our studies reveal the intriguing nonalternant structures and physical properties of this type of nanoribbons, involving the striking effects of the multiple annulated pentagons, and also provide fundamental insights into their electronic structures.
1, 2‐trans‐Stereoselective 7‐O‐Glycosylation of Flavonoids with Unprotected Pyranoses by Mitsunobu Reaction
Authors: Shi Hailong , Yang Jian , Cheng Yao , Yang Jinlian , Lu Xiaoxia , Ma Xiaofeng 
Published: March 2022

AbstractThe glycosylation of protecting‐group‐free pyranoses with flavonoids to generate flavonoid O‐glycosides under Mitsunobu conditions was reported. The methodology allows to prepare a wide range of natural 7‐flavonoid O‐glycosides and their derivatives from commercially available chemicals in good to excellent yields with exclusive 1,2‐trans‐stereoselectivity regardless the anomeric configuration of employed pyranoses. The highly regioselective glycosylation was also achieved among different types of hydroxyl groups on the glycosyl acceptors.
Upper confidence bound integrated genetic algorithm‐optimized long short‐term memory network for click‐through rate prediction
Authors: Souissi Bilel , Ghorbel Ahmed 
Published: March 2022

AbstractData on online advertising is rising rapidly due to the fast development of science and technology. Click‐through rate (CTR) prediction has become a critical task regarding the digital advertising industry and a key element in increasing advertising profits and user experience. Therefore, this article describes the problem of CTR prediction as a function of sequence classification tasks. Then, we proposed a novel optimization strategy to solve the high‐dimensional problem and find a subset of relevant variables to ensure high performance of our model and maximize the number of clicks. Here, we introduced a feature selection and hyper‐parameter optimization approach using genetic algorithms (GA) and the upper confidence bound (UCB) model to optimize micro‐targeting technology, along with the long short‐term memory (LSTM) network‐based CTR prediction model. The efficiency of the proposed UCB‐LSTM‐GA model and two hybrid models, namely LSTM‐GA and LSTM‐PSO, is evaluated by comparing them to each other and to other machine‐learning‐based classification methods, including LSTM using a UCB algorithm (UCB‐LSTM), High‐order Attentive Factorization Machine (HoAFM), genetic algorithm‐artificial neural network (GA‐ANN), and a feature interaction graph neural network model (Fi‐GNN). Our solution achieved as high as 87%, 89%, and 92% for respectively accuracy, precision, and recall, using the popular python tools with real Avazu datasets.
Power of Partnerships: Public Health and Water Systems Protect Community Health Together
Authors: Robb Kate , Via Steve , McDonald Ambria , Kerner Bridget , Wright Sarah , DeJarnett Natasha , Bhattacharyya Sanjib , Dettmer Karen , Adams Hunter , Nix Daniel , Latshaw Megan Weil 
Published: March 2022

Key TakeawaysWater systems can positively influence public well‐being by teaming up with health agencies.Two case studies are presented that show how this collaborative work can happen at a local level.In the United States, the Lead and Copper Rule Revisions open the way for stronger communications across the water and public health sectors.
Protecting Against Water Rate Challenges With the Equivalent of Bear Spray
Authors: Wittern Matt , Gaur Sanjay 
Published: March 2022

Key TakeawaysA California water utility was sued over its water budget–based rate structure designed to help customers conserve the state's most precious resource.The case was followed closely by many in the industry looking for ways to endure the ever‐present threat of water scarcity.The utility successfully defended itself and shares lessons learned for other water agencies facing rate challenges.
When do people rely more on unique versus common attributes? The effect of power distance belief on preference for alignable versus nonalignable attributes
Authors: Lee Hyejin , Cho Hyewon 
Published: March 2022

AbstractThis research examines the relationship between power distance belief (PDB)—the extent to which people accept and endorse hierarchy and inequality—and consumers' preferences for alignable (vs. nonalignable) attributes when making a choice. Through four experiments, we find that high PDB individuals are more likely to rely on alignable attributes, while low PDB individuals are more likely to rely on nonalignable attributes. We further propose and demonstrate that cognitive flexibility underlies this effect such that high (vs. low) PDB individuals have lower cognitive flexibility, which, in turn, increases their reliance on alignable attributes when making a choice. Theoretical and managerial implications are discussed.
Synthesis of Functionalized δ‐Hydroxy‐β‐keto Esters and Evaluation of Their Anti‐inflammatory Properties
Authors: Grosse Michel , Günther Kerstin , Jordan Paul M. , Roman Dávid , Werz Oliver , Beemelmanns Christine 
Published: March 2022

Abstractδ‐Hydroxy‐β‐keto esters and δ,β‐dihydroxy esters are characteristic structural motifs of statin‐type natural products and drug candidates. Here, we describe the synthesis of functionalized δ‐hydroxy‐β‐keto esters in good yields and excellent enantioselectivities using Chan's diene and modified Mukaiyama‐aldol reaction conditions. Diastereoselective reduction of δ,β‐dihydroxy esters afforded the respective syn‐ and anti‐diols, and saponification yielded the corresponding acids. All products were evaluated for their anti‐inflammatory properties, which uncovered a surprising structure‐activity relationship.
Closure of spontaneous cerebrospinal fluid leakage via fistula at the lateral wall of the sphenoid sinus using a bone pile
Authors: Takabayashi Kosuke , Gotoh Shuho , Yamasaki Maeho , Takizawa Katsumi 
Published: March 2022

AbstractThis report describes a case of spontaneous cerebrospinal fluid leak through a narrow canal‐like fistula in the lateral wall of the sphenoid sinus, which was managed through rigid reconstruction. Rigid reconstruction of the skull base was performed by fitting a pile‐shaped bone into the fistula like the pile‐driving technique.
Bochdalek hernia with liver herniation
Authors: Kanatani Mao , Taniguchi Hirokazu , Kusabiraki Kimiho , Masaki Yasuaki , Tsuda Takeshi , Abo Hitoshi 
Published: March 2022

AbstractBochdalek hernia with liver herniation is rare and mimics a pulmonary mass. This case was hospitalized for masses found in the lower field of the right lung on a chest radiograph. The patient was diagnosed with Bochdalek hernia with liver herniation with three‐dimensional images created from thoracoabdominal‐enhanced computed tomography.
Severe pancytopenia caused by trifluridine/tipiracil in patients with metastatic colorectal cancer and an impaired renal function: A case report
Authors: Shibutani Masatsune , Okazaki Yuki , Kashiwagi Shinichiro , Nagahara Hisashi , Fukuoka Tatsunari , Iseki Yasuhito , Maeda Kiyoshi , Hirakawa Kosei , Ohira Masaichi 
Published: March 2022

AbstractAlthough the incidence of hematological toxicity due to Trifluridine/tipiracil (FTD/TPI) treatment is high, the incidence of severe adverse events has been reported to be relatively low. However, it should be noted that patients with renal impairment are prone to severe hematological adverse events.
Unravelling Anion Solvation in Water‐Alcohol Mixtures by Single Entity Electrochemistry
Authors: Saw En Ning , Kanokkanchana Kannasoot , Amin Hatem M. A. , Tschulik Kristina 
Published: March 2022

AbstractInvited for this month's cover picture is the group of Prof. Dr. Kristina Tschulik from the Ruhr University Bochum (Germany). The cover picture illustrates how the different solvent shells forming in water/alcohol solvent mixtures can be probed by single particle electrochemistry thanks to the resulting difference in diffusion speeds of the solvated ions. This effect is reflected in the time needed for the full oxidation of a single nanoparticle arriving at a microelectrode, which is limited by the halide ion transport towards the nanoparticle under suitable conditions. Read the full text of the Research Article at 10.1002/celc.202101435.
Volumetric intersections: Modularization approaches for freeform prefab concrete construction
Authors: Stieler David , Schwinn Tobias , Menges Achim 
Published: March 2022

AbstractThe pursuit for more load‐adapted, individualized, and at the same time precise building geometries is driving innovation in digital fabrication with concrete towards greater formal freedom and higher degrees of prefabrication. This article reviews the opportunities of using three‐dimensional (3D)‐printed formwork in the context of pre‐fabricated concrete construction. It identifies the geometric specificities future planning tools need to address to incorporate the steps of modularization and fabrication into automatized planning processes from design to production. By reviewing the state‐of‐the‐art fabrication methods for nonstandard concrete geometries, we highlight possible applications and challenges for additive formwork and introduce a volumetric modeling approach to modularize surface and mesh‐based 3D design models into solid segments that can form the basis for further formwork planning.
Adrenal gland cytology reporting: a multi‐institutional proposal for a standardized reporting system
Authors: Trabzonlu Levent , Jager Lucy , Tabibi Seena , Compton Margaret L. , Weiss Vivian L. , Kanber Yonca , Robila Valentina , Antic Tatjana , Maleki Zahra , Morency Elizabeth , Barkan Güliz A. 
Published: March 2022

BACKGROUNDWith the development of new technologies and the changing patient profiles, cytopathology departments receive increasing numbers of adrenal gland cytology specimens. In this study, the authors analyzed archival adrenal gland cytology cases and attempted to implement a diagnostic reporting system.DESIGNRetrospective electronic medical record search was performed for adrenal gland cytology specimens in seven tertiary care centers. The cytology diagnoses were grouped in 7 categories: nondiagnostic, nonneoplastic, benign adrenal cortical elements (BACE), primary neoplasm of noncortical origin (NONC), atypia of undetermined significance (AUS), suspicious for malignancy (SM), and malignant (MAL). If available, histopathology results of concurrent and/or follow‐up biopsies and/or resections were documented.RESULTSA total of 473 adrenal gland cytology cases were included. BACE cases comprised 21.8%, whereas MAL cases were 57.5% of all cases. For BACE and MAL categories, there were 100% and 98.9% correlation, respectively, in the cases with histopathology follow‐up. Six of 10 NONC cases had histopathology diagnoses and there were 3 pheochromocytomas and 3 schwannomas. Twenty‐one AUS cases had histology follow‐up and 10 (47.6%) of them were malignant. Six cases of SM had histopathology follow‐up, and all of them were malignant on the follow‐up.CONCLUSIONSThe authors propose a 7‐tier diagnostic scheme for adrenal gland cytology. The risk of malignancy was 98.9% in MAL cases (87/88) in the cohort. The only case with discordance was reported as “adrenal cortical adenoma with marked atypia”' on resection. There was no difference between endoscopic ultrasound‐guided and percutaneous methods. Further studies are needed to validate and make this approach universal.;
Organic Polymers Combining Boron Cluster and Triazine: An Ultra‐efficient Adsorption Separator toward Cationic Dyes
Authors: Yang Ziqiong , Chen Hao , Huang Bihong , Huang Miluo , Ding Qiong , Zhang Haibo 
Published: March 2022

AbstractAlthough organic polymer/framework materials have demonstrated outstanding potential for application as dye scavenger in hydrology system, challenges on adsorption capacity limited their industrial utilization in the fields such as sewage treatment and environmental safety. Herein, we synthesized boron cluster organic polymers (BOPs) by grafting four triazine derivative molecules onto a boron cluster (B12H122−) in aqueous phase through an ion‐exchange process. Remarkably, the resulting BOPs have a maximum adsorption capacity of 2053 mg g−1 and 1033 mg g−1, respectively, for rhodamine B (RB) and methylene blue (MB) from the aqueous phase. Even in RB/MB mixtures, BOPs exhibited a selective separation capacity via simply adjusting the pH values. The high stability, striking recyclability and excellent selectivity further indicated the promise of this adsorption separator for potential applications in dye removal and separation.
Regional differences in treatment and outcome for myeloma patients in Sweden: A population based Swedish myeloma register study
Authors: Wålinder Göran , Genell Anna , Juliusson Gunnar , Svensson Ronald , Santamaria Antonio Izarra , Crafoord Jacob , Carlson Kristina , Knut‐Bojanowska Dorota , Veskovski Ljupco , Lauri Birgitta , Lund Johan , Turesson Ingemar , Hansson Markus , Blimark Cecilie Hveding , Nahi Hareth 
Published: March 2022

AbstractBackgroundWe wanted to evaluate if health care for multiple myeloma (MM) patients is equal in different regions of Sweden.AimTo study differences in survival for MM depending on health care region and early use of modern treatment.Methods and resultsData from the Swedish Myeloma Register from patients diagnosed between 2008 and 2017 was used. Cohorts were defined by the six healthcare regions (labeled A–F) in Sweden and modern initial treatment was defined as including certain drug combinations. To adjust for time to treatment bias, survival analyses were performed also for patients alive 6 months after diagnosis. In all treated MM patients (n = 5326), we observed a superior overall survival (OS) for region A compared to all other regions (p < .01 for all respectively). After adjusting for time to treatment there was also a superior survival in the region with highest use of modern initial treatment (region A) compared to the regions defined in the study as having intermediate and low use (p < .01 for both). In patients receiving autologous stem cell transplantation (ASCT) a superior survival was observed for region A compared to all regions besides region B. Similar results were seen when adjusting for a time to treatment bias. In patients not receiving ASCT, 75 years or older and adjusted for time to treatment bias, a difference was noted only between region A and E (log rank p = .04, HR 1.2, CI 1.00–1.44, p = .06). In multivariate analyses including age, international staging system stage and time period of diagnosis, differences in survival remained for patients receiving ASCT between region A versus C, D, E and F (p = .01, p < .01, p < .01, p = .03).ConclusionWe observed a superior survival in region A for patients receiving ASCT. Explanations may be higher usage of modern initial treatment or regional residual confounding. For patients not receiving ASCT, 75 years or older, differences in survival could be adjusted for.
Preorganized Homochiral Pyrrole‐Based Receptors that Display Enantioselective Anion Binding
Authors: Karges Johannes , Cohen Seth M. 
Published: March 2022

AbstractHerein, a new scaffold for anion recognition based on a tripodal tris(pyrrolamide) motif is presented. The receptors were able to bind to a variety of anions with high affinity. Using density functional theory methods, the three‐dimensional geometry of the receptor‐anion complex was calculated. These calculations show that the receptors bind anions via a preorganized cavity of amide and pyrrole hydrogen bond donor groups. Based on these findings, homochiral tris(pyrrolamide) receptors were prepared, which produced 1.6‐fold greater affinity for (S)‐(+)‐mandelate over (R)‐(−)‐mandelate, demonstrating the ability to differentiate between these enantiomeric anions. The interaction of (S)‐(+)‐mandelate and (R)‐(−)‐mandelate within the homochiral receptor was examined by solution NMR spectroscopy and theoretical calculations. These findings indicate that the preorganized positioning of the pyrrole groups and subsequent sterics allows to differentiate between the stereoisomeric anions.
Alignments between e‐waste legislation and the Sustainable Development Goals: the United Kingdom, Brazil, and Ghana case studies
Authors: Lopes dos Santos Kauê , Jacobi Pedro Roberto 
Published: March 2022

AbstractThe first two decades of the 21st century had a significant increase in e‐waste generation. While improper recycling technologies applied to this type of waste pose severe risks to the environment and human health, several e‐waste management legislation has been recently enforced worldwide, reaching 78 countries and covering 71% of the global population. In common, most of them aim to recycle minerals and plastic from the disposed waste of electric and electronic equipment (WEEE) to reinsert them in the industry, promoting the so‐called circular economy. From the comparative case study of countries that integrate the world‐system in different social and economic conditions – the United Kingdom (as core or developed country), Brazil (as semi‐periphery or emergent country), and Ghana (as periphery or developing country) –, this article aims to understand to what extent the national legislation on e‐waste management in these territories align with the Sustainable Development Goals 3, 6, 8, 11, 12, 14, and 15. This research has an exploratory approach and is methodologically structured as a controlled comparison of most different cases. Results reveal that selected legislation has different levels of alignment with SDG, ranging from generic mentions of social‐environmental topics to description of legal instruments to be enforced regarding environmental preservation, improvement of population's life quality, and changes in the unsustainable production, consumption, and disposal patterns. The article also seeks to contribute to the geographical debate by establishing the relation between e‐waste legislation and SDG, considering the territorial particularities of the case studies.
Fibrinogen regulates lesion border‐forming reactive astrocyte properties after vascular damage
Authors: Conforti Pasquale , Mezey Szilvia , Nath Suvra , Chu Yu‐Hsuan , Malik Subash C. , Martínez Santamaría Jose C. , Deshpande Sachin S. , Pous Lauriane , Zieger Barbara , Schachtrup Christian 
Published: March 2022

AbstractReactive astrocytes at the border of damaged neuronal tissue organize into a barrier surrounding the fibrotic lesion core, separating this central region of inflammation and fibrosis from healthy tissue. Astrocytes are essential to form the border and for wound repair but interfere with neuronal regeneration. However, the mechanisms driving these astrocytes during central nervous system (CNS) disease are unknown. Here we show that blood‐derived fibrinogen is enriched at the interface of lesion border‐forming elongated astrocytes after cortical brain injury. Anticoagulant treatment depleting fibrinogen reduces astrocyte reactivity, extracellular matrix deposition and inflammation with no change in the spread of inflammation, whereas inhibiting fibrinogen conversion into fibrin did not significantly alter astrocyte reactivity, but changed the deposition of astrocyte extracellular matrix. RNA sequencing of fluorescence‐activated cell sorting‐isolated astrocytes of fibrinogen‐depleted mice after cortical injury revealed repressed gene expression signatures associated with astrocyte reactivity, extracellular matrix deposition and immune‐response regulation, as well as increased gene expression signatures associated with astrocyte metabolism and astrocyte‐neuron communication. Systemic pharmacologic depletion of fibrinogen resulted in the absence of elongated, border‐forming astrocytes and increased the survival of neurons in the lesion core after cortical injury. These results identify fibrinogen as a critical trigger for lesion border‐forming astrocyte properties in CNS disease.