bluuebunny/crossref_metadata_2025_split huggingface dataset:
Synthesis and structural characterization using the Rietveld method of the quaternary compound CuAlGeSe4
Authors: Delgado Gerzon E. , Quintero Miguel 
Published: February 2022

Sample of the quaternary phase CuAlGeSe4, a member of the I-III-IV--VI4 semiconductor system, was synthesized by the melt and annealing technique and analyzed using X-ray powder diffraction data. The indexing and refinement of the pattern indicate that this compound crystallizes in the tetragonal system, space group I (Nº82) with unit cell parameters: a = 5.5646(3) Å, c = 10.682(2) Å, V = 330.77(5) Å3. The space group was established from a cationic and anionic distribution analysis in the tetragonal space groups: I2d (Nº 122), I2m (Nº 121), and I (Nº 82), for an ordered structure in this material. The Rietveld refinement, performed with the starting model: Cu 2c, Al 2b, Ge 2d,  2a, and Se 8g, converged to Rexp= 7.2%, RP = 7.4%, Rwp = 9.6%, and χ2 = 1.7.
Systematic Review of Treatment of Metastatic Non-Clear Cell Renal Cell Carcinoma
Authors: Brown Jason R. , Calaway Adam , Castle Erik , Garcia Jorge , Barata Pedro C. 
Published: February 2022

BACKGROUND: Metastatic and unresectable non-clear cell renal cell carcinoma comprises more than a quarter of kidney cancers but does not have standardized treatment. Non-clear renal carcinoma consists of a variety of diverse histologic subtypes, including papillary, chromophobe, collecting duct, translocation, and medullary histologies, many of which carry a poor prognosis. Many prospective clinical trials exclude these kidney cancers, and for most clinical trials of non-clear cell renal cell carcinoma, only a small number of patients are enrolled. OBJECTIVE: To perform a systematic review of recently published and currently enrolling prospective clinical trials for advanced non-clear cell renal cell carcinoma. METHODS: A systematic search of Pubmed and MEDLINE (Ovid) was conducted as per PRISMA guidelines to identify recent prospective clinical trials in non-clear cell renal cell carcinoma. To ensure a thorough search, terms not only included non-clear cell renal carcinoma but also molecular subtypes. A review of currently enrolling clinical trials was conducted on Clinicaltrials.gov and the EU Clinical Trials Register as well. RESULTS: A total of 33 prospective clinical trials with published results and 10 currently enrolling clinicals trials were identified. About half (48.5%) of these studies were reported in 2020 or 2021, and 36.4% were in the first-line setting. Treatments investigated in these trials included mTOR inhibitors, VEGF- and MET-targeted tyrosine kinase inhibitors, immune checkpoint inhibitors, and combinatorial strategies. Outcomes from these data revealed a wide range of response rate and progression free survival, favoring TKIs and immune checkpoint inhibitors -based combination regimens. CONCLUSIONS: Novel targeted therapies and immunotherapies have changed the landscape of treatment for advanced non-clear cell renal cell carcinoma. Combination regimens may provide even further clinical benefit and warrant further investigation in larger, randomized prospective clinical trials.
Peran Orang Tua dalam Membimbing Anak Belajar dari Rumah di Masa Pandemi Covid-19
Authors: Fitriah Fitriah , Asyriah Noor , Amrullah M. Kholis , Hidayatullah Hidayatullah 
Published: February 2022

The role of parents in guiding their children to study from home or study online is very important, especially for children at the elementary school level, because during the learning process, sometimes children did not understand what to do for the assignments, and some of them cannot operate the learning supporting devices properly. This condition challenges parents, because they must guide their children to study from home and derive their responsibility as Civil Servants that must be completed and cannot be abandoned.
This research was a case study that examined the role of parents who work as Civil Servants in guiding their children to study from home during the Covid-19. The data collection techniques used were semi-structured interviews, observation, and documentation to 8 parents and their children.
The study found that there were three roles of civil servant parents in guiding their children to study from home. Those roles were as a teacher in which parents teach subjects that must be mastered by their children in accordance with the educational curriculum; a facilitator in which parents provide children's needs to support the online learning process, and a motivator in which parents maintain the learning motivation of their children by giving the reward or punishment and attention.
Set Up Time Reduction Using Single Minute Exchange of Dies (SMED) and 5S: A Case Study
Authors: Runtuk Johan Krisnanto 
Published: February 2022

<p><em>Manufacturing excellence represents the goal for every manufacturing industry all around the world. Reducing waste could help achieve manufacturing excellence since waste could happen in every manufacturing industry. PT. As one of the food and beverages industry, </em><em>PT. </em><em>MNO also focuses on reducing waste in the production process, especially in the filling department. Similar to other departments, the filling department also has planned and unplanned stoppages. As one of the planned stoppages, the setup activities represent one of the highest waste contributions in the filling department. Therefore, PT. MNO can reduce the setup time using the Single Minute Exchange of Dies (SMED) and 5S method. Then, the overall equipment effectiveness (OEE) calculation can show the differences between filling machine productivity before and after Single Minute Exchange of Dies (SMED) and the 5S method. As a result, the setup time is reduced from 34 minutes to 13 minutes by using the Single Minutes Exchange of Dies (SMED) method implementation. After the 5S method implementation, the setup time becomes ten minutes. The overall equipment effectiveness (OEE) calculation result shows better productivity after SMED and 5S method implementation in the filling department by the increasing OEE rate from 76% to 78% in the end.</em></p><p><em> </em></p><p><em>Keywords: Setup, waste, planned stoppages, Single Minute Exchange of Dies (SMED), 5S, Overall Equipment Effectiveness (OEE)</em></p>
Manajemen Asuhan Kebidanan pada Nn. R dengan Kista Bartholin
Authors: B Sarafudin Nurfani , Sundari Sundari , Erawati Micha 
Published: February 2022

Berdasarkan studi pendahuluan yang dilakukan di RSKDIA Sitti Fatimah tanggal 12 desember 2019, jumlah ibu dengan gangguan sistem reproduksi dari bulan November 2018- desember 2019 didapatkan mioma uteri sebanyak 17 kasus, kista ovarium sebanyak 23 kasus, menometroragi sebanyak 12 kasus, kista bartholin sebanyak 4 kasus dan berdasarkan data Indonesia, sebuah penelitian deskriptif retrospektif yang dilakukan di RSUD Dr. Soetomo Surabaya, periode 2012-2014, melaporkan dari jumlah kunjungan divisi penyakit menular seksual ditemukan 46 pasien kista bartholin(1,29%) dan 25 pasien abses Bartholini (0,7% ). Kista bartholin adalah infeksi pada kelenjar bartholini atau barthonilitis juga dapat menimbulkan pembekakan pada alat kelamin luar wanita. Biasanya disertai dengan nyeri hebat bahkan sampai tidak bisa berjalan. Juga dapat disertai demam, sering pembekakan pada kelamin yang memerah.) Besar kelenjar bartholini ini berdiameter sekitar 0,5 cm yang ditemukan dilabia minora, biasanya tak teraba bila dilakukan palpasi. Pasien yang dikaji dalam laporan tugas akhir ini adalah Nn”R” , 27 tahun, belum menikah, Suku Makassar, Agama Islam, Pendidikan SMA, Pekerjaan Wiraswasta, Alamat Jl. Laccukang lr.1 No.13, dan Pasien masuk di RS mengeluh ada benjolan sebesar biji kelereng di labia mayora sebelah kanan dan di rasakan sejak 2 minggu yang lalu dan akan dilakukan tindakan marsupialisasi. Hasil tinjauan kasus dengan tinjauan pustaka telah diuraikan dan tidak ditemukan adanya kesenjangan antara tinjauan kasus dengan tinjauan pustaka serta upaya yang dilakukan berdasarkan lingkup tugas, wewenang, dan tanggung jawab bidan. Setelah mengevaluasi hasil yang telah dilakukan pada Nn” R” disimpulkan bahwa hasil Kista Bartholin sudah teratasi, isi kista telah dikeluarkan, leukosit kembali normal dan nyeri terasa berkurang.
Manajemen Asuhan Kebidanan Antenatal Care pada Ny. A dengan Hiperemesis Gravidarum Tingkat II
Authors: Amahoru Rifkawati , M Azrida , Hadriyanti Hamang Sitti 
Published: February 2022

Kehamilan dengan Hiperemesis gravidarum berdasarkan data Word Health Organization WHO (2015) mencapai 14,8% dari seluruh kehamilan di dunia dengan angka kejadian yang beragam yaitu mulai dari 0,3 di Swedia, 0,5% di California, 0,8% di Canada, 10,8% di China, 0,9% di Norwegia, 2,2% di Pakistan dan 1,9% di Turki serta di Amerika Serikat, prevalensi hiperemesis gravidarum adalah 0,5-2%, sedangkan angka kejadian hyperemesis gravidarum di Indonesia adalah mulai dari 1-3% dari seluruh kehamilan. Hiperemesi Gravidarum adalah mual muntah yang terjadi pada awal kehamilan sampai umur kehamilan 20 minggu. Keluhan muntah kadang-kadang begitu hebat di mana segala apa yang dimakan dan diminum dimuntahkan. Sehingga dapat mempengaruhi keadaan umum dan mengganggu pekerjaan sehari-hari, berat badan menurun, dehidrasi, dan terdapat aseton dalam urine bahkan seperti gejala penyakit apenditis, pielitis dan sebagainya. Pasien yang dikaji dalam Laporan Tugas Akhir ini adalah Ny.”A”. pengkajian dilakukan dengan mengumpulkan data secara subjektif dan objektif dengan diagnosa aktual hiperemesis gravidarum tingkat II, diagnosa masalah potensial antisipasi terjadinya hiperemesis gravidarum tingakat III, dan tidak ada tindakan kolaborasi. Berdasarkan tinjauan pustaka, evaluasi yang dilakukan penulis tidak mendapatkan permasalahan atau kesenjangan karena seluruh masalah yang ada pada Ny “A” dapat diatasi dengan baik. Tujuan disusunnya laporan Tugas Akhir (LTA) ini untuk memberikan asuhan kepada Ny “A” dengan hiperemesis gravidarum di RSKDIA Sitti Fatimah Makassar tahun 2019. Dengan menggunakan pendekatan Manajemen Asuhan Kebidanan sesuai dengan kewenangan bidan .
Protocolo antibiótico pre y posquirúrgico de terceros molares
Authors: Anampa Paucar Marian Antonia , Butron Alvarez Ximena Dayana , Mamani Colque Ivana Daniela , Quispe Ticona Darmely Helen , Mamani Ticona Elias Juan , Rodriguez Espinoza Luhana , Vargas Quispe Rosmery Esmeralda , Sosa Huanca Carlos André 
Published: February 2022

El tratamiento quirúrgico dental de terceros molares, frecuentemente, requiere un protocolo antibiótico profiláctico y un tratamiento farmacológico posterior a la cirugía. Analizar dichos protocolos fue el objetivo de este estudio; para ello se realizaron búsquedas electrónicas en las principales bases de datos (PubMed, SciELO, Science y repositorios de diferentes universidades) en las cuales se identificaron ensayos, revisiones sistemáticas, metaanálisis, tesis y estudios de diferentes tipos. La búsqueda se filtró entre el periodo 2016 a 2021 y se determinó que antibióticos como la amoxicilina, amoxicilina/ácido clavulánico, son los antibióticos profilácticos de primera elección, ya que sobresalen por diferentes propiedades, entre ellas, reducción significativa del riesgo de infección (hasta un 99.9 %). La profilaxis tiene como fin prevenir el posible desarrollo de enfermedades infecciosas, también evitar proliferación y diseminación de bacterias que puedan originar estas, sobre todo en pacientes no inmunocompetentes.
O idoso portador de Alzheimer e o cuidador familiar: contribuições da teoria de alcance de metas de Imogene King
Authors: Bezerra Any Karoliny Soares , Bezerra Eduarda Karolyne Silva , Nogueira Emília Cervino , Almeida Jussiana Penha da Silva , Ramos Letícia de Souza , Vieira Manuela de Carvalho Martins 
Published: February 2022

Objetivo: Refletir sobre a contribuição da Teoria do Alcance de Metas de Imogene King na construção de uma assistência efetiva ao cuidador familiar do idoso portador de Alzheimer. Metodologia: Revisão integrativa de literatura realizada nas bases de dados: SCIELO, BVS, LILACS e Medline/Pubmed a partir de estudos disponíveis em inglês, português e espanhol, publicados entre 2016 e 2021. Resultados: Foram selecionados 19 artigos que possuíam relevância para esta revisão. Entre os sintomas neuropsiquiátricos apresentados pelos idosos, apatia, ansiedade e depressão são os mais frequentes. Estudos também apontam perda de memória, linguagem, funções cognitivas, controle emocional, social e perda da motivação. Os cuidadores de idosos com Alzheimer necessitam de suporte profissional de saúde, organização da família, atenção médica pessoal e apoio emocional. É importante incentivar o bem-estar próprio do cuidador para garantir e melhorar o acesso aos cuidados de saúde, prevenir o declínio funcional desses cuidadores, oferecendo orientações sobre o cuidado de maneira adequada e com menor risco. Devem-se utilizar tecnologias de cuidado adaptadas para o ambiente domiciliar e gerontotecnologias que contribuem diretamente no cuidado, assim promovendo um cuidado informativo e educativo. Conclusão: O cuidador familiar é aquele que possui o maior contato com o idoso portador de Alzheimer. Neste sentido, a Teoria do Alcance de Metas proposta por Imogene King permite compreender sobre o impacto do cuidado ao paciente portador de Alzheimer no cuidador familiar, suas necessidades pessoais, bem como a estratégias que podem ser utilizadas a fim se alcançar as metas estabelecidas no apoio a esse cuidador.
INTELLECTUAL UTOPIA OF YURII SHEREKH
Authors: Vasylenko Vadym 
Published: February 2022

The paper examines the literary-critical views of Yurii Sherekh of the Artistic Ukrainian Movement’s (MUR) period, clarifes his understanding of ‘visnykivstvo’ and ‘Kyiv neoclassicism’ as literary phenomena, the content and significance of the theory of ‘national organic style’, and the idea of antaeism. The worldview and aesthetic positions of Yurii Sherekh are considered in the context of ideological and literary discussions of the late 1940s. The research involved the literary-critical and historical literary studies written by Yurii Sherekh in the postwar period and interpreted their textual connections with the works by Yurii Sherekh himself and by his intellectual associates and opponents. Yurii Sherekh’s idea of the ‘national organic style’ was not only one of the stages of the literary researcher’s worldview evolution, but also a certain result of the development of Ukrainian literary-critical thought in the mid-20th century. This idea grew out of the literary experience of the 1920s and was associated with the process of updating the national artistic tradition and adopting Western Europe literature’s achievements in the 1940s. The approval of the idea of ‘national-organic style’ in the ideological and aesthetic concepts of Yurii Sherekh was accompanied by the rejection of the ‘Vistnyk’s’ and ‘neoclassical’ traditions. The analysis of the main points of Yurii Sherekh’s polemic with Dmytro Dontsov as a symbolic representative of the “Vistnyk’s” ideology and Volodymyr Derzhavyn as the main supporter of the ‘neoclassicism’ theory reveals some inconsistency of Yurii Sherekh’s definitions of neoclassicism. Yurii Sherekh’s idea of antaeism was a certain Ukrainian equivalent of European existentialism, rooted in the history and philosophy of Ukrainian resistance.
The paradox of Yuri Sherekh’s theory was in combining the desire for modernity with the return to tradition, while the dogmatism of his ‘national organic’ approach to certain phenomena and works somewhat ideologized his assessments and views. There are reasons to tell about the conventionality of Yurii Sherekh’s division of the Ukrainian mid-20th century writers into ‘organists’ and ‘Europeists’, who visualized, on his opinion, two main directions of Ukrainian literature’s development. In fact, the various types of ‘Europeanism’ and ‘organicity’ were inevitably intertwined.
EGR1 and KLF4 as Diagnostic Markers for Abdominal Aortic Aneurysm and Associated With Immune Infiltration
Authors: Guo Chunguang , Liu Zaoqu , Yu Yin , Zhou Zhibin , Ma Ke , Zhang Linfeng , Dang Qin , Liu Long , Wang Libo , Zhang Shuai , Hua Zhaohui , Han Xinwei , Li Zhen 
Published: February 2022

BackgroundFormation and rupture of abdominal aortic aneurysm (AAA) is fatal, and the pathological processes and molecular mechanisms underlying its formation and development are unclear. Perivascular adipose tissue (PVAT) has attracted extensive attention as a newly defined secretory organ, and we aim to explore the potential association between PVAT and AAA.MethodsWe analyzed gene expression and clinical data of 30 PVAT around AAA and 30 PVAT around normal abdominal aorta (NAA). The diagnostic markers and immune cell infiltration of PVAT were further investigated by WGCNA, CIBERSORT, PPI, and multiple machine learning algorisms (including LASSO, RF, and SVM). Subsequently, eight-week-old C57BL/6 male mice (n = 10) were used to construct AAA models, and aorta samples were collected for molecular validation. Meanwhile, fifty-five peripheral venous blood samples from patients (AAA vs. normal: 40:15) in our hospital were used as an inhouse cohort to validate the diagnostic markers by qRT-PCR. The diagnostic efficacy of biomarkers was assessed by receiver operating characteristic (ROC) curve, area under the ROC (AUC), and concordance index (C-index).ResultsA total of 75 genes in the Grey60 module were identified by WGCNA. To select the genes most associated with PVAT in the grey60 module, three algorithms (including LASSO, RF, and SVM) and PPI were applied. EGR1 and KLF4 were identified as diagnostic markers of PVAT, with high accurate AUCs of 0.916, 0.926, and 0.948 (combined two markers). Additionally, the two biomarkers also displayed accurate diagnostic efficacy in the mice and inhouse cohorts, with AUCs and C-indexes all &gt;0.8. Compared with the NAA group, PVAT around AAA was more abundant in multiple immune cell infiltration. Ultimately, the immune-related analysis revealed that EGR1 and KLF4 were associated with mast cells, T cells, and plasma cells.ConclusionEGR1 and KLF4 were diagnostic markers of PVAT around AAA and associated with multiple immune cells.
Assessment of Associations Between Serum Lipoprotein (a) Levels and Atherosclerotic Vascular Diseases in Hungarian Patients With Familial Hypercholesterolemia Using Data Mining and Machine Learning
Authors: Németh Ákos , Daróczy Bálint , Juhász Lilla , Fülöp Péter , Harangi Mariann , Paragh György 
Published: February 2022

Background and aims: Premature mortality due to atherosclerotic vascular disease is very high in Hungary in comparison with international prevalence rates, though the estimated prevalence of familial hypercholesterolemia (FH) is in line with the data of other European countries. Previous studies have shown that high lipoprotein(a)- Lp(a) levels are associated with an increased risk of atherosclerotic vascular diseases in patients with FH. We aimed to assess the associations of serum Lp(a) levels and such vascular diseases in FH using data mining methods and machine learning techniques in the Northern Great Plain region of Hungary.Methods: Medical records of 590,500 patients were included in our study. Based on the data from previously diagnosed FH patients using the Dutch Lipid Clinic Network scores (≥7 was evaluated as probable or definite FH), we trained machine learning models to identify FH patients.Results: We identified 459 patients with FH and 221 of them had data available on Lp(a). Patients with FH had significantly higher Lp(a) levels compared to non-FH subjects [236 (92.5; 698.5) vs. 167 (80.2; 431.5) mg/L, p &lt; .01]. Also 35.3% of FH patients had Lp(a) levels &gt;500 mg/L. Atherosclerotic complications were significantly more frequent in FH patients compared to patients without FH (46.6 vs. 13.9%). However, contrary to several other previous studies, we could not find significant associations between serum Lp(a) levels and atherosclerotic vascular diseases in the studied Hungarian FH patient group.Conclusion: The extremely high burden of vascular disease is mainly explained by the unhealthy lifestyle of our patients (i.e., high prevalence of smoking, unhealthy diet and physical inactivity resulting in obesity and hypertension). The lack of associations between serum Lp(a) levels and atherosclerotic vascular diseases in Hungarian FH patients may be due to the high prevalence of these risk factors, that mask the deleterious effect of Lp(a).
Impact of Succinylcholine vs. Rocuronium on Apnea Duration for Rapid Sequence Induction: A Prospective Cohort Study
Authors: Tang Lijun , Zhao Xiao , Li Shitong , Huang Lina , Li Jinbao , Chen Lianhua , Huang Shiwei 
Published: February 2022

ObjectiveThe present study aimed to evaluate the impact of 1.5 mg/kg succinylcholine or 1.2 mg/kg rocuronium, vs. 1.0 mg/kg succinylcholine on apnea duration in patients underwent rapid sequence induction (RSI).MethodsThis prospective cohort study was conducted in the Department of Anesthesiology in Shanghai General Hospital from July 2020 to November 2020. Apnea duration was defined as the time from apnea prompted by the PETCO2 waveform to the time the point of oxygen saturation declined to 90% (T90) and 95% (T95) after succinylcholine or rocuronium administration. The primary outcome included T90 and T95 changes in 1.5 mg/kg vs. 1.0 mg/kg succinylcholine groups and 1.5 mg/kg succinylcholine vs. 1.2 mg/kg rocuronium groups.ResultsA total of 265 participants were subjected for analysis. The succinylcholine (1.0 mg/kg) group had a significantly longer T90 (50.72, 95% confidence interval [CI, 7.60, 94.38], P = 0.015) and T95 (48.09, 95% CI [7.11, 89.07], P = 0.012) than the succinylcholine (1.5 mg/kg) group. In addition, significantly longer T90 (56.84, 95% CI [16.24, 97.44], P = 0.003) and T95 (50.57, 95% CI [12.58, 88.57], P = 0.003) were observed in the rocuronium (1.2 mg/kg) group than those in the succinylcholine (1.5 mg/kg) group. No severe side events were observed during the operation.ConclusionRocuronium and the lower dose of succinylcholine may be recommended to patients underwent RSI.