bluuebunny/crossref_metadata_2025_split huggingface dataset:
Intensity Matters: Impact of Physical Activity Energy Expenditure at Moderate and Vigorous Intensity on Total and Abdominal Obesity in Children
Authors: Sardinha Luís , Magalhães João , Santos Diana , Hetherington-Rauth Megan 
Published: July 2022

Abstract
Background/Objectives:
Physical activity (PA) guidelines advocate that children should accumulate at least 60 minutes of moderate-to-vigorous PA daily. Still, it is not clear how the body composition profile may differ if the same dose of PA if accumulated at different intensities. We aimed to determine the independent associations of energy expenditure (EE) at moderate (MPA) and vigorous (VPA) PA intensity on total and abdominal fat in children and if these associations were moderated by cardiorespiratory fitness (CRF).
Subjects/Methods:
A total of 326 children, (girls = 171, boys n = 151) aged 10–12 years had PA assessed with accelerometers. Total fat mass index (FMI) and abdominal FMI were assessed with DXA. CRF was assessed by a cycle ergometer test. Linear regression models were used to model the outcomes with the inclusion of an interaction term to test for moderation effects.
Results
An inverse association was found between VPA EE and FMI (β=-0.013, p < 0.001) and abdominal FMI (β=-0.0014, p < 0.001) independent of MPA EE. In contrast, MPA EE was not related to adiposity independent of VPA EE (p > 0.05). The relationships between the PA intensities and FMI and abdominal FMI were moderated by CRF. MPA EE was positively associated with adiposity in children with high levels of CRF, whereas VPA EE remained inversely associated with adiposity regardless of CRF level, although the strength of the association was lower in those with higher CRF levels.
Conclusion
PA programs should provide opportunities for children to perform VPA in order to achieve healthier body composition profiles and avoid excess adiposity.
Circular RNA hsa_circ_0007444 inhibits ovarian cancer progression through miR-23a-3p/DICER1axis
Authors: Zhang Min , Sun Yu , Xu Hanzi , Shi Yaqian , Shen Rong , Teng Fang , Xu Juan , Jia Xuemei 
Published: July 2022

Abstract
Background
Ovarian cancer is the leading cause of death in women with gynecological malignancy. Circular RNAs are a class of noncoding regulatory RNAs reported to be involved in cancer development and progression. Previous studies, including our own, have indicated that hsa_circ_0007444 is downregulated in ovarian cancer tissues. Our study aims to elucidate the function and mechanism of hsa_circ_0007444 in ovarian cancer progression.
Methods
The expression of hsa_circ_0007444 was determined by quantitative real-time PCR (qRT-PCR). Cell proliferation, invasion, migration and apoptosis were examined by cell counting-kit 8 (CCK-8), transwell, and flow cytometry assays. Tumor growth and metastasis were assessed in vivo using Balb/c nude mouse xenograft model and tail vein injection model. And the mechanism of action of hsa_circ_0007444 was analyzed by RNA-binding protein immunoprecipitation (RIP), luciferase reporter and rescue assays.
Results
Hsa_circ_0007444 was downregulated in ovarian cancer cell lines compared with normal ovarian epithelial cell line. Gain- and loss-of-function results indicated that hsa_circ_0007444 inhibited cell proliferation, invasion, migration and increased cell apoptosis of ovarian cancer cells in vitro and inhibited the tumor growth and lung metastasis in vivo. Additionally, the results of the bioinformatics analysis, and RIP, luciferase reporter and rescue assays confirmed that hsa_circ_0007444 can interact with AGO2 and sponge the microRNA miR-23a-3p, thereby upregulating DICER1 expression, which is an important tumor suppressor in ovarian cancer.
Conclusions
Hsa_circ_0007444 can inhibit ovarian cancer progression through the hsa_circ_0007444/miR-23a-3p/DICER1 axis.
Microwave In situ Inactivation in the Treatment of Bone Giant Cell Tumor: A Mid-term Descriptive Study
Authors: Jiang Xiang , Chen Jianan , Zhou Wei , Zhang Chen , Wang Guodong , Dong Dan , Xia Pingguang , Liu Ximing , Xu Feng 
Published: July 2022

Abstract
Introduction/AimsTo evaluate the mid-term clinical efficacy of microwave in situ inactivation combined with bone grafting or polymethyl methacrylate (PMMA) filling in the treatment of giant cell tumor of bone (GCTB).Methods This is a retrospective, descriptive and analytical study. A total of 30 GCTB patients received microwave in situ inactivation from January 2012 to January 2020, whose clinical recurrence rate was evaluated at the last follow-up after microwave in situ inactivation surgery. The Musculoskeletal Tumor Society (MSTS) function score was used to evaluate the postoperative clinical panoramic results.Results All patients were followed up for 21 to 110 months, with an average of 63.79 months. Distal femur (40%) and proximal tibia (28%) had a higher rate of GCTB incidence. Seventeen percent of tumor patients suffered from associated pathologic fracture. The rate of Campanacci classification stage III was 60%. The average MSTS score was evaluated as 27.53 points overall at the last follow-up. In terms of complications, three, two, two and one cases developed fat liquefaction, controllable tissue rejection reaction, incision infection and degenerative changes around lesion joint, respectively, without in situ recurrences and reoperation as well as distant lung metastasis. Conclusions The method of microwave in situ inactivation combined with bone grafting or PMMA filling is prudently recommended as one of the options for the limb salvage treatment of giant cell tumor of long and periarticular bone.Level of EvidenceIV: Case series
Competitive spreading model and control strategies of negative emotions and intervention information in heterogeneous social networks
Authors: Wang Tiantian , Liu Tiezhong , Lu Yunmeng , Li XiaoWei 
Published: July 2022

Abstract
Emotions play an important role in individual decision making, and emotional contagion affects both individual and group-level behaviors. Particularly, in the case of emergencies, the contagion of negative emotions may have an extremely negative impact on the stability of society. However, emergency management is equally likely to take measures during the spread of negative emotions. In this context, we designed a model to discuss the dynamic characteristics of competing propagation of negative emotions and intervention information in heterogeneous social networks. Firstly, the basic reproduction number and propagation threshold for the propagation of negative emotions in the presence of intervening information are calculated based on the existence of the positive equilibrium points. Secondly, the existence and stability of equilibrium points of the model are analyzed based on the theory of infectious disease dynamics, Lyapunov stability and LaSalle’s invariance principle. Thirdly, three different control strategies are investigated, including uniform immunization control, active immunization control and optimal control. Finally, we numerically simulate the proposed model and the relative importance of the different factors contributing to the spread and prevalence of negative emotions is discussed through a sensitivity analysis, which can provide the best strategies for reducing the spread of negative emotions.
Patterns in the growth and thematic evolution of Artificial Intelligence research: A study using Bradford distribution of productivity and Path Analysis
Authors: Gupta Solanki , Kanaujia Anurag , Lathabai Hiran H , Singh Vivek Kumar 
Published: July 2022

Abstract
AI Applications has led to changes in social as well as economic structure of the world and caused worldwide policy changes. AI research and applications have not only increased in volume but has also expanded across various disciplines. Newer themes of research have emerged while attention on several topics has gradually faded. Therefore, there is a need to analyse and understand the patterns of growth and thematic evolution of AI research during the last decade. Motivated by the need, Bibliometric methodologies of Bradford’s law and Path analysis are employed to develop a framework for a detailed analysis. Publication and citation data of AI for the period 2010 to 2020 obtained from Web of Science when analysed using this framework, showed an exponential growth between 2016 and 2020. An increased adoption of AI in novel domains is indicated by an increase in both concentration and dispersion of the literature. Through the analysis of evolutionary trajectories contributing to growth of AI, it was observed that applications of AI are becoming common in previously unrelated areas such as water resource management, environment management, building technology, healthcare etc. These are areas which directly relate with sustainable development and the researchers have used multiple single as well as hybrid AI tools to address their problems. The article presents useful insight along these lines which can be useful for practitioners in the field of AI.
Successful clinical practices to prevent necrotizing enterocolitis drive different microbiome profiles and functional responses in the preterm intestine
Authors: Neumann Charlotte , Mahnert Alexander , Kumpitsch Christina , Kiu Raymond , Dalby Matthew , Kujawska Magdalena , Madl Tobias , Kurath-Koller Stefan , Urlesberger Berndt , Resch Bernhard , Hall Lindsay , Moissl-Eichinger Christine 
Published: July 2022

Abstract
Preterm infants with very low birthweight are at serious risk for necrotizing enterocolitis. To functionally analyse the principles of three successful preventive NEC regimens, we characterized faecal samples of 54 infants (< 1,500 g, n = 383) longitudinally (two weeks) with respect to gut microbiome profiles (bacteria, archaea, fungi, viruses), microbial function, virulence factors, antibiotic resistances and metabolic profiles, including human milk oligosaccharides (HMOs) and short-chain fatty acids. Probiotic Bifidobacterium longum ssp. infantis supplementation affected microbiome development globally, pointing toward the genomic potential to convert HMOs. Engraftment of Bifidobacterium substantially reduced microbiome-associated antibiotic resistance as compared to regimens using probiotic Lactobacillus rhamnosus or no supplementation. Crucially, the beneficial effects of Bifidobacterium supplementation depended on simultaneous feeding with HMOs. We demonstrate that preventive regimens have the highest impact on early maturation of the gastrointestinal microbiome, enabling the establishment of a resilient microbial ecosystem that reduces pathogenic threats in at-risk preterm infants.
Southern Extension of Raccoon dog Nyctereutes procyonoides (Mammalia: Carnivora: Canidae) range in Vietnam with comments on its conservation status in the country
Authors: Pham Thong Van , Trinh Mai Thi , Gray Russell J. , Cao Long Nhat , Nguyen Tan Van , Nguyen Manh Van , Vo Tuan Cong Anh , Nguyen Nga Thi , Nguyen Long Thi , Tran Cuong Xuan , Willcox Daniel , Nguyen Thai Van 
Published: July 2022

Abstract
Although the Raccoon dog (Nyctereutes procyonoides) has a wide global distribution, little is known about its population in Vietnam. The species is considered rare in Vietnam and few records have been published since 2004; though it is worth noting that all of these records were wildlife trade observations or anecdotal reports. Here we report Raccoon dogs recorded in the illegal wildlife trade via Facebook monitoring from January to December 2020, rescued animals documented in the same province caught by a hunter in August 2020, and camera trap records of the species detected in Pu Mat National Park in May and July 2021. Our camera trap records represent a southern extension of the known range of this species in Vietnam, and is the first known instance of the Racoon dogs recorded in-situ by camera traps in the country.
Prevalence and Clinical Characteristics of Patients with Advanced Chronic Illness and Palliative Care Needs Identified with the NECPAL CCOMS-ICO© Tool at a Tertiary Care Hospital
Authors: Calsina-Berna Agnès , Novellas Jordi Amblàs , González-Barboteo Jesús , Robles Ignasi Bardés , Alba Elba Beas , Martínez-Muñoz Marisa , Sánchez Rafael Madariaga , Alentorn Xavier Gómez Batiste 
Published: July 2022

Abstract
Background: The identification of advanced chronic patients with palliative care needs is essential since the care of advanced chronicity represents one of the main challenges for public health systems. The study aimed to determine the prevalence and characteristics of inpatients with palliative care needs in different services of a tertiary care hospital using the NECPAL CCOMS-ICO© tool.Methods: A descriptive, cross-sectional cohort study was conducted in a tertiary hospital. Patients were classified as Non-NECPAL, NECPAL I-II, and NECPAL III, depending on the NECPAL tool criteria they met. The presence of physical symptoms, emotional distress, and social risk factors was assessed. Results: Of the 602 inpatients, 236 (39.2%) were enrolled. Of them: 34 (14.4%) non-NECPAL, 202 (85.6 %) NECPAL+ [105 (44.5%) NECPAL I-II, and 97 (41.1%) NECPAL III]. Physical symptom burden was high (pain intensity ≥1 in 68.3% of patients; tiredness ≥1 in 83.5%; somnolence ≥1 in 50.6%; dyspnea ≥1 in 37.9%; anorexia ≥1 in 59.5%). 64.1% had emotional distress and 83.6% social risk factors. The NECPAL-III group contained a higher percentage of cancer patients, higher demand for palliative care, and greater need for palliative care (p<0.001). In 50.8% of cases, no referrals were made to psychology, social work, or hospital palliative support care teams. The three services with the higher number of patients with palliative care needs were: Palliative Care Unit (100%), Oncology (54.54%), and Emergency Short-stay Unit (54.16%). Conclusions: A high percentage of patients admitted to tertiary care hospitals presented palliative care needs, with multiple unmet physical, emotional, and social needs. However, these patients are rarely referred to specialized care teams, such as hospital palliative support care teams.
Alleviative effect of threonine on cadmium-induced acute liver injury in mice
Authors: Fang Zhijia , Li Yongbin , Wang Jingwen , Wang Xinran , Huang Linru , Sun Lijun , Deng Qi 
Published: July 2022

Abstract
As a toxic pollutant, cadmium (Cd) can cause severe liver injury. In the previous study, we found that threonine (Thr) significantly alleviated the toxic effect of Cd in yeast. To investigate the effect of Thr on Cd-induced liver damage in mice, twenty-four mice were evenly divided into control, Cd-exposed, and low/high dose of Thr-treatment groups (0.04, 0.08 mmol/kg/day) for 7 days of continuous treatment. Thr significantly reduced the aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels, exhibiting alleviative effect on hepatic injury. Further investigation showed that Thr significantly reduced the Cd-induced inflammation (tumor necrosis factor-α and interleukin-6), and inhibited the increase of apoptosis factors (Bax and Caspase-3). Thr also reduced liver malondialdehyde (MDA) and O2− level, and restored superoxide dismutase (SOD) activity. In conclusion, Thr alleviated Cd-induced hepatic tissue and dysfunction through reducing the formation of free radicals O2−, lipid peroxidation, inflammation, and inhibiting the expression of Bax and Caspase-3.
The eruption of 22 April 2021 as observed by SolarOrbiter, STEREO and Earth bound instruments
Authors: Rodriguez L. , Warmuth A. , Andretta V. , Mierla M. , Zhukov A. N. , Shukhobodskaia D. , Niemela A. , A. Maharana , West M. J. , Kilpua E. K. J. , Möstl C. , D'Huys E. , Veronig A. M. , Auchère F. , Battaglia A. F. , Benvenuto F. , Berghmans D. , Dickson E. C. M. , Dominique M. , Gissot S. , Hayes L. A. , Katsiyannis T. , Kraaikamp E. , Landini F. , Magdalenic J. , Mann G. , Massa P. , Nicula B. , Piana M. , Podladchikova O. , Sasso C. , Schuller F. , Stegen K. , Susino R. , Uslenghi M. , Verbeeck C. 
Published: July 2022

Abstract
The Extreme Ultraviolet Imager (EUI) onboard Solar Orbiter ob-served an eruption through both of its channels (17.4/30.4 nm) of its Full Sun Imager, on 22 April 2021. At the time, the spacecraft was at 0.87 au from the Sun,and 98◦ east of the Sun-Earth line. The eruption was slightly back-sided, emerging close to the southwest limb, starting at 04:24 UT, with the source located at S20W103 from the Solar Orbiter perspective. The Solar Orbiter coronagraph, Metis, observed the CME at 06:05 UT. The Spectrometer/Telescope for Imaging X-rays (STIX) on Solar Orbiter sampled the associated X-ray flare, which was partially occulted. This allowed the characterization of both the thermal plasmaand any potential contribution of non-thermal electrons in the tenuous coronal source. The X-ray source location is compared to the extreme ultraviolet coronal structures seen by EUI, and it is established that STIX imager only sees the top part of the flaring loops, while most of the flare – in particular the non-thermal foot points – remain occulted.
From the Earth’s perspective the eruption source region was observed at S20W05 (close to disk centre), the Atmospheric Imaging Assembly (AIA), onboard the Solar Dynamics Observatory (SDO) and the Sun Watcher using Active Pixel System detector and Image Processing (SWAP), onboard the PRoject for OnboardAutonomy (PROBA2) observed dimmings and an associated large-scale coronal wave starting around 04:07 UT. The Extreme Ultraviolet Imager (EUVI) on the Solar-TErrestial RElations Observatory (STEREO-A), located 53◦ east of the Sun-Earth line at the time, observed similar signatures of an eruption starting around 04:17 UT, on-disk at S20W50. The corresponding CME was observedas a partial halo CME shortly after (∼06:00 UT) by the C2 Large Angle and Spectrometric Coronagraph (LASCO), from the Earth perspective onboard the SOlar and Heliospheric Observatory (SOHO), and by the STEREO-A/COR2 coronagraph as a clear structured CME around 05:23 UT.
The corresponding ICME arrived at Earth on 24 April 2021, it was driving ashock and created minor geomagnetic storm conditions. We simulate the CMEwith the 3D MHD heliospheric model EUHFORIA. We provide an analysis ofthe eruption as observed by these various instruments from different vantage points. The combination of data from Solar Orbiter as well as other space-based assets with numerical modeling clearly showcases the scientific potential for the science phase of Solar Orbiter, and the unique observations available.
Single Posterior Approach for Circumferential Debridement and Anterior Reconstruction Using fibular allograft in Patients with Skipped Multifocal Spinal Tuberculosis
Authors: Chiu Yen-Chun , Yang Shih-Chieh , Kao Yu-Hsien , Tu Yuan-Kun 
Published: July 2022

Abstract
Background: Skipped multifocal spinal tuberculosis (TB) is an atypical presentation of spinal TB. Surgical treatment for these unusual cases remains a challenge for spine surgeons. In our institute, we used single-stage circumferential debridement and anterior reconstruction with fibular allograft followed by posterior instrumentation through posterior-only approach for these patients. This study aimed to determine the efficacy and feasibility of this technique.Methods: Twelve patients with skipped multifocal spinal TB who received our treatment method from January 2012 to June 2020 were enrolled in this study. The visual analog score (VAS), laboratory data, comorbidities, complications, and neurologic status based on Frankel scale were recorded. The patients’ clinical conditions were evaluated based on modified Brodsky’s criteria and Oswestry Disability Index (ODI).Results: All the patients were infection free at the end of the treatment. The average VAS score was 7.5 (range, 7 to 8) before surgery and decreased to 2.1 (range, 1 to 3) one year postoperatively. No one experienced any severe complications such as neurologic deterioration, fixation failure, or bone graft dislodgement. Out of the three patients requiring debridement surgery, two had wound infection and one had seroma formation. The ODI score improved from 76.8 (range, 70 to 84) preoperatively to 25.5 (range, 22 to 28) one year after surgery. All patients achieved good or excellent outcome based on modified Brodsky’s criteria one year postoperatively.Conclusions: In our study, the patients could achieve a good clinical outcome. This technique could be an alternative for patients with skipped spinal TB.
ATPergic signaling disruption in human sepsis as a potential source of biomarkers for clinical use
Authors: Leite Rafael Olivé , de Souza Priscila Oliveira , Haas Clarissa Branco , Silveira Fernando da , Mohr Kauan , Bertoni Ana Paula Santin , Soares Mayara S. Pereira , Azambuja Juliana H. , Prá Morgana Dal , Cruz Lorraynne Letycia Prado da , Gelsleichter Nicolly Espindola , Begnini Karine , Haskó George , Wink Márcia R. , Spanevello Roselia M. , Braganhol Elizandra 
Published: July 2022

Abstract
Sepsis is a life-threatening organ dysfunction caused by a dysregulated inflammatory response to infection. To date, there is no specific treatment established for sepsis. In the extracellular compartment, purines such as adenosine triphosphate (ATP) and adenosine play essential roles in the immune/inflammatory responses during sepsis and septic shock. The balance of extracellular levels among ATP and adenosine are intimately involved in the signals related to immune stimulation/immunosuppression balance. Specialized enzymes, including CD39, CD73, and adenosine deaminase (ADA), are responsible to metabolize ATP to adenosine which will further sensitize the P2 and P1 purinoceptors, respectively. Disruption of the purinergic pathway had been described in the sepsis pathophysiology. Although purinergic signaling has been suggested as a potential target for sepsis treatment, the majority of data available was obtained using pre-clinical approaches. We hypothesized that, as a reflection of deregulation on purinergic signaling, septic patients exhibit differential measurements of serum, neutrophils and monocytes purinergic pathway markers when compared to two types of controls (ward and healthy). It was observed that ATP and ADP serum levels were increased in septic patients, as well as the A2a mRNA expression in neutrophils and monocytes. Both ATPase/ADPase activities were increased during sepsis. Serum ATP and ADP levels, and both ATPase and ADPase activities were associated with the diagnosis of sepsis, representing potential biomarkers candidates. In conclusion, our results advance the translation of purinergic signaling from pre-clinical models into the clinical setting opening opportunities for so much needed new strategies for sepsis and septic shock diagnostics and treatment.