bluuebunny/crossref_metadata_2025_split huggingface dataset:
Design of COMT-Knockout mouse as a preeclampsia mode
Authors: Chirinskaite Angelina V. , Fotina Aleksandra S. , Markova Ekaterina V. , Vishnyakova Polina A. , Poltavets Anastasiya S. , Sopova Julia V. , Leonova Elena I. 
Published: December 2022

Preeclampsia is a multisystem pregnancy disorder that occurs after 20 weeks of gestation, leading to e.g. preterm labor. It is characterized by hypertension, proteinuria, edema, and multiple organ dysfunction. Up to 8% of pregnancies are complicated by preeclampsia, which is one of the most serious causes of maternal and perinatal mortality [1]. For research of pregnancy disorders and development of therapy for it, a mouse model can be used due of the fact that pregnancy development in mice, especially at early stages, is somewhat similar to human and is well-studied, in particular, in terms of molecular biology [2]. One of the possible options for creating mouse models of preeclampsia is considered to be a mutation in the COMT gene encoding сatechol-O-methyltransferase [3]. This enzyme plays an important role in the catecholamines conversion and it also catalyzes the O-methylation of hydroxyestradiol producing methoxyestradiol. COMT gene knockout results in a phenotype similar to preeclampsia with elevated blood pressure and proteinuria [3]. The previous model was obtained through classic transgenesis methods with Neomycin cassette insertion in the COMT locus potentially influencing the results of the experiments. The development of the genome editing systems and its active utilization at Saint Petersburg State University made it possible to obtain a COMT-KO mouse line using CRISPR/Cas9 technology which had not been done in Russia before. This model will allow to effectively study the development of preeclampsia and ways to prevent and treat it.
This work was supported by a Saint Petersburg State University grant for the development of scientific research (ID 92561695).
Estimation of Damage Scenarios in Mexico City Caused by Nearby Crustal Earthquakes
Authors: Suárez Gerardo , Jaimes Miguel A. 
Published: December 2022

ABSTRACT
Mexico City has sustained severe damage from earthquakes located in the subduction zone and within the subducted Cocos plate. The city lies in the trans-Mexican volcanic belt (TMVB). Earthquakes in the TMVB are relatively infrequent but have reached Mw&gt;6. A recent Mw 6.9 crustal earthquake occurred in 1912, 80 km from Mexico City. Damage scenarios are estimated for two hypothetical crustal earthquakes located 40 and 80 km from the city. The seismic sources represent hazard-critical earthquakes and are based on historical seismicity and on the geological record. The probability distribution of ground acceleration is determined by ground-motion models (GMMs) from similar tectonic regions. Site effects are included to account for the geotechnical zonation of the city, and vulnerability curves are calculated for residential buildings in the cadastral record of Mexico City. The results show that an earthquake near the 1912 earthquake would produce accelerations of 37 and 148  cm/s2 on firm ground and in the lake region, respectively. In this scenario, damage is concentrated in buildings 1-2 stories high located near the transition zone. The earthquake located ∼40 km from Mexico City shows accelerations of 79 and 318  cm/s2 on firm ground and in the lake region, respectively. This scenario concentrated potential damage in buildings 1-2 stories high and broadly distributed in the region underlain by soft clays. Under both scenarios, no damage is expected in buildings higher than ∼11 stories. A deterministic approach using two potential seismic sources instead of a probabilistic seismic hazard model is used because of the lack of background seismicity and the unknown recurrence times of events in the TMVB. The results show very different damage patterns for crustal earthquakes. The two scenarios presented here may be useful for decision makers and insurance companies to estimate physical damage and to implement mitigation programs.
Sovereign debt in a post-war period: endogenous opportunities and exogenous challenges for Ukraine
Authors: Hryhoriev Hennadiy 
Published: December 2022

The purpose of this study is to present possible scenarios for assessing the levels of Ukraine’s sovereign debt burden in the context of the cumulative effect of Ukraine’s pre-war and post-war debt accumulation to avoid sovereign debt overload or even sovereign default and achieve debt relief.The methodology of the article is based on the theory of international finance using the scientific method of system dynamics as an applied method of analysis. The main purpose of the article was to find the way out of the concession debt trap, but the Russian military aggression against Ukraine in February 2022 significantly changed the purpose of the analysis. As a result, as far as possible, an element of military economics was added to the article.The dynamic interpretation of the research problem is formulated as: “What are the possible dynamics of falling into a sovereign debt trap and, ultimately, into political dependence through external infrastructure financing before and after the war, and how can such a trap be avoided?” It is necessary to recognize such a trap in advance, because, fortunately, Ukraine has not yet fully got there.The results of the study are important in the application of the national debt policy model.
JEL classіfіcatіon: C73, E17, H56, H60, H81
Corporate cultural responsibility as a component of company branding in Ukraine
Authors: Humenna Oleksandra , Bedii Nazar 
Published: December 2022

The objective of the study is to reveal the essence and features of corporate cultural responsibility (CCR) and its role in managing the company’s brand.Research methods. The research is based on the Synthesis Methods, including comparative analysis, interpretation, and applying systematic research synthesis.Research results. The article reveals the need to introduce and use CSR as a branch of corporate social responsibility. The relevance of the study is due to the importance of using CCR in the formation of business and marketing strategies of companies and brands, which can provide economic benefits and even affect the level of national security.The study emphasizes that today, during the full-scale Russian war against Ukraine and the genocide of Ukrainians by the Russian Federation, the issue of protection, preservation, promotion, and development of Ukrainian culture by businesses operating in Ukraine is more urgent than ever before. Therefore, the article substantiates the role of CCR in Ukraine as a phenomenon that will encourage businesses to take a responsible approach to the choice of influencers with whom businesses cooperate for advertising purposes; implementing elements of Ukrainian culture in its products, services, and/or communications; priority provision of sponsorship (financial or media) support for advertising purposes specifically to Ukrainian cultural figures and/or projects; proofreading of information about the culture and history of Ukraine, provided they are used in products, services and communications.The usage of the results. According to the results of the study, a list of steps for implementing the CCR in Ukrainian business for successful branding is proposed as recommendations, namely the implementation of the CCR at the level of company strategy; corporate culture of the company; product/service; in the company’s external communications. The proposed recommendations should solve the following tasks: cultural and social – the development and popularization of Ukrainian culture in Ukraine and the world; business and communication – reducing business reputational risks and strengthening the reputation of a company or its brand among Ukrainian consumers, which will have a long-term positive economic effect on business. Conclusions. The proposed recommendations are designed to solve the following two tasks – cultural and social: development and popularization of Ukrainian culture in Ukraine and in the world; business and communication: reducing business reputational risks and strengthening the reputation of the company or its brand among Ukrainian consumers, which under other normal circumstances will have a long-term positive economic effect on business. Further research in the area of the introduction of CCR in Ukraine will be aimed at deepening the analysis of the impact of CCR on modern brands and determining the economic effects of CCR on the activities of companies.
JEL classіfіcatіon: М14, L21
Identification of Pathogenic Bacteria in Food Samples from Cafeterias of A University in Denpasar, Indonesia
Authors: Anak Agung Ayu Lila Paramasatiari  , Putu Indah Budiapsari  , Putu Arya Suryanditha  , Ni Wayan Widhidewi  
Published: December 2022

Highlights:

Eschericia colli was the most contaminant bacteria among food samples from Warmadewa Cafeterias
Further suggestions to increase the hygiene in food processing must be offered.

Abstract :
Foodborne diseases still remain a problem especially in public areas. This study aimed to identify pathogenic bacteria in foods sold at the cafeterias of Universitas Warmadewa, Denpasar, Indonesia. The presence of pathogenic bacteria in the food samples was identified using the brain heart infusion (BHI) agar for the growth of Escherichia coli and Streptococcus aureus, selenite for Shigella and Salmonella, and alkaline peptone for Vibrio cholerae, then bacterial culture was conducted to identify the species. The results showed that Escherichia coli were found in two food samples, kangkong and jinggo rice, with the colony counts of 50-118. Escherichia coli was the most commonly found contaminant in food samples from the Warmadewa Cafeterias. Further suggestions must be offered to increase hygiene in the food processing by advising the stalls’ owners to serve good foods and conducting regular inspections to assess the food quality.
Clinical Importance of Sarcopenia And How It Impacts Orthopaedic-Trauma Patients and The Surgical Outcomes
Authors: Fauzi Ahmad , Idrial David , Asdi Akbar Rizki Beni 
Published: December 2022

Highlights:

Sarcopenia can cause deleterious effects on patients.
The Asian Working Group for Sarcopenia (AWGS) and the European Working Group on Sarcopenia in Older People (EWGSOP) provide the most widely used criteria to diagnose sarcopenia.
Knowledge of sarcopenia should be a trigger for clinicians and surgeons to evaluate the treatment plan and anticipate the implications experienced by the patients.

Abstract:
Sarcopenia is a condition of low muscle strength, mass, and low physical performance that is affected by age (primary sarcopenia) and one or combination of systemic diseases, physical inactivity, and insufficient intake of energy (secondary sarcopenia). This condition affects one in ten healthy adults aged ≥60 years. There are two widely used criteria to diagnose sarcopenia, the Asian Working Group for Sarcopenia (AWGS) and the European Working Group on Sarcopenia in Older People (EWGSOP). These working groups created algorithms to facilitate the diagnosis. Establishing the diagnosis is crucial because it has deleterious impacts on patients, such as increasing risks of mortality, morbidity, falls, complications during and after surgery, disability, prolonged hospitalization, and fractures. Sarcopenia is considered an independent mortality risk. It is paramount for physicians to assess this condition before treating the patients because it can predict the risk and plan better treatment options to achieve better outcomes. Early assessment is crucial, even for surgeons. Sarcopenia also negatively impacts patients who had surgery. Up to 44% patients who underwent orthopedic trauma surgery had sarcopenia. The high percentage was affected by the increased risk of falls and fractures. On that account, this condition needs to be treated. The main treatments for this condition are exercise dan adequate nutrition intake. The recommended exercise as a first-line treatment is resistance or strength training. Overall, knowledge on sarcopenia can prepare clinicians and surgeons in anticipating the implications of sarcopenia.
Hubungan Tingkat Pengetahuan terhadap Perilaku Swamedikasi Gastritis pada Mahasiswa Prodi Farmasi Universitas Hang Tuah di Surabaya
Authors: Kresnamurti Angelica , Farida Nuraini , Jayanto Irvan 
Published: December 2022

Swamedikasi merupakan suatu upaya yang dilakukan untuk mengobati penyakit ringan dengan pemilihan obat-obatan yang tepat. Jika swamedikasi tidak dilakukan dengan tepat akan membuat penyakit semakin parah. Pengetahuan yang baik dapat membantu masyarakat melakukan swamedikasi dengan baik dan tepat. Gastritis adalah gangguan kesehatan yang disebabkan oleh faktor iritasi dan infeksi pada mukosa dan submukosa lambung. Tujuan penelitian ini adalah untuk menganalisis tingkat pengetahuan terhadap perilaku swamedikasi pada mahasiswa. Rancangan penelitian yang digunakan adalah analitik observasional, dengan desain penelitian Cross Sectional. Tehnik pengumpulan sampel menggunakan Purposive Sampling, dengan jumlah sampel 96 orang yang memenuhi kriteria inklusi. Instrumen penelitian ini adalah kuisioner pengetahuan dan perilaku sebanyak 10 pertanyaan dengan pilihan jawaban berskala Guttman yang telah valid dan skala likert yang telah valid 11 pertanyaan. Penelitian ini dilakukan pada bulan Juni-Agustus 2021 pada Prodi Farmasi Universitas Hang Tuah di Surabaya. Analisis data menggunakan SPSS versi 26. Analisis statitik korelasi pada penelitian ini menggunakan korelasi Rank Spearman. Hasil analisis menunjukkan taraf singnifikasi sebesar 0,041 yang berarti adanya hubungan yang signifikan antara tingkat pengetahuan dan perilaku swamedikasi gastritis, Nilai r hitung diperoleh sebesar 0,347 menunjukkan bahwa kedua variabel memiliki hubungan cukup. Dari hasil korelasi dapat menunjukkan angka korelasi positif yang berarti kedua variabel tersebut memiliki jenis hubungan yang searah.
EFFECT OF SONICATION ON THE PROPERTIES OF COMPOSITE POLYPYRROLE/MICROCELLULOSE AND ITS POTENTIAL AS A CAPACITOR
Authors: Sitorus Berlian , Pranata Deni , Bara’allo Malino Mariana 
Published: December 2022

The research aims to see the effect of sonication on the properties and capacitance of composites made of microcellulose isolated from Oil Palm Empty Fruit Bunches and Polypyrrole (PPy). PPy is a conductive polymer limited by its inflexibility; hence PPy is blended with microcellulose which can serve as a good matrix to increase the flexibility of PPy. The procedure to isolate the microcellulose was done by delignification, bleaching, and hydrolysis. In order to see the effect of sonication, hydrolysis was undertaken in two different ways : (i) without sonication and (ii) using sonication. Besides, the polymerization time for pyrrole was also varied: 4 and 16 hours and simultaneously composited with each microcellulose from (i) and (ii). The results show an increase in cellulose crystallinity from 35.6% without sonication to 40% after sonication, while the diameter of the sonicated microcellulose fibers tends to be smaller than the counterpart. The 4-hour polymerization time shows that the composite containing the unsonicated microcellulose has a higher capacitance than the composite with the sonicated microcellulose, 14.8 nF and 8.8 nF, respectively. Meanwhile, a similar capacitance is measured for the 16-hour polymerization, 1.90 nF and 2.68 nF, using the sonicated and un-sonicated microcellulose. Overall, although the capacitances of the composites are in the nanofarad scale, it can be said that the composite can be potentially used as a capacitor.
Faktor-Faktor yang Mempengaruhi Penggunaan Aplikasi E-Wallet Dana Di Kota Samarinda
Authors: Utami Rezki Aguswidya , Irwansyah Irwansyah 
Published: December 2022

ABSTRACT This study develops the Unified Theory of Acceptance and Use of Technology 2 (UTAUT 2) model. UTAUT 2 consists of the variables of performance expectancy, effort expectancy, social influence, facilitating conditions, hedonic motivation, price value, habit, behavioral intention, and use behavior. This study aims to examine the effect of the factors in the UTAUT 2 model on user behavior in using the DANA e-wallet application.This study uses a quantitative approach with an explanatory type. A sample of 90 users of the DANA application in Samarinda City was selected by accidental sampling. The causality test uses partial least squares.The results showed that performance expectancy and price value have positive and significant effects on behavioral intention; habit and behavioral intention have positive and significant effects on use behavior; effort expectancy and facilitating conditions have negative and insignificant effects on use behavior; social influence has negative yet significant effect on behavioral intention; and hedonic motivation has positive but not significant effect on behavioral intention. Keywords: UTAUT 2, Performance Expectancy, Effort Expectancy, Social Influence, Facilitating Conditions, Hedonic Motivation, Price Value, Habit, Behavioral Intention, Use Behavior
KERAGAMAN SPESIES TUMBUHAN BERKHASIAT OBAT BERDASARKAN PENGETAHUAN MASYARAKAT DESA PENYANGGA EKOSISTEM GAMBUT TAHURA OKH PROVINSI JAMBI
Authors: Anggraini Dera , Iswandaru Dian , Wulandari Christine , Novriyanti Novriyanti 
Published: December 2022

Berbagai spesies tumbuhan sebenarnya telah dimanfaatkan oleh berbagai tipologi masyarakat di dunia karena diyakini dapat memelihara kesehatan dan meringankan bahkan mengobati berbagai masalah tubuh. Akan tetapi pengetahuan mengenai hal ini pada masyarakat yang tinggal di sekitar ekosistem gambut belum terdokumentasikan secara ilmiah. Penelitian ini bertujuan untuk mengidentifikasi dan mengulas keragaman spesies tumbuhan berkhasiat obat atau pemelihara kesehatan masyarakat sekitar gambut Tahura Orang Kayo Hitam (OKH). Salah satu desa di Tahura OKH Provinsi Jambi dipilih untuk diteliti dengan pemilihan responden secara purposive. Data mengenai berbagai spesies tumbuhan berkhasiat obat atau pemelihara kesehatan, khasiat tiap spesies tumbuhan, bagian tubuh spesies tumbuhan yang sering digunakan, teknik pemanfaatan, dan intensitas penggunaannya digali melalui wawancara terbuka dengan panduan kuisioner. Temuan penelitian menunjukkan sebanyak 31 spesies tumbuhan digunakan masyarakat untuk mengatasi berbagai permasalahan kesehatan. Masalah kesehatan yang paling banyak diobati menggunakan tumbuhan diantaranya ialah tekanan darah tinggi (hipertensi), nyeri kaku pada sendi, radang sendi, dan demam. Spesies yang paling banyak disebut bermanfaat berdasarkan pengetahuan masyarakat ialah kunyit (Curcuma longa). Selain itu ada pula sirsak (Annona muricata), duku (Lansium domesticum), kumis kucing (Orthosiphon aristatus), dan jahe merah (Zingiber officinale).
ANALISIS KEBUTUHAN BAHAN AJAR MATA KULIAH GIZI DAN KESEHATAN BERORIENTASI LAHAN BASAH
Authors: Yulinda Ratna , Putri Rizky Febriyani 
Published: December 2022

Tujuan penelitian ini untuk menganalisis kebutuhan bahan ajar mata kuliah Gizi dan Kesehatan berorientasi lahan basah. Analisis kebutuhan bahan ajar ini merupakan bagian dari tahapan pendefinisian (define) pada penelitian lain yang menggunakan pengembangan bahan ajar dengan model 4D (Define, Design, Develop, Dessiminate). Teknik pengumpulan data menggunakan teknik angket melalui penyebaran googleform. Penelitian ini dilakukan pada bulan Mei sampai dengan Juni 2021 di program studi Pendidikan IPA FKIP Universitas Lambung Mangkurat. Partisipan dalam penelitian ini adalah mahasiswa program studi pendidikan IPA yang telah menempuh mata kuliah gizi dan kesehatan. Jumlah partisipan sebanyak 91 orang. Hasil penelitian menunjukkan bahwa sebagian besar mahasiswa membutuhkan bahan ajar berupa modul, buku ajar, Lembar Kerja Mahasiswa (LKM) dan Hand Out dengan memuat kearifan lokal daerah Kalimantan Selatan. Kegiatan pembelajaran yang diharapkan adalah melalui kegiatan observasi (praktikum), ceramah, diskusi serta Tanya jawab. Berdasarkan hasil tersebut dapat disimpulkan bahwa diperlukan bahan ajar yang berupa modul maupun buku ajar yang memuat kearifan lokal daerah Kalimantan Selatan, serta dosen pengampu mata kuliah merancang kegiatan pembelajaran yang disertai dengan observasi, ceramah, diskusi serta tanya jawab.
PENGARUH MODEL PEMBELAJARAN INKUIRI TERBIMBING TERHADAP HASIL BELAJAR PESERTA DIDIK KELAS V PADA MATA PELAJARAN IPA
Authors: Nanda Suci , Zannah Fathul , Riadin Agung 
Published: December 2022

Salah satu masalah pendidikan yang ada pada saat ini yaitu pada proses pembelajaran yang hanya menekankan peserta didik untuk menghafal berbagai informasi tanpa bisa mengaitkannya dengan kehidupan sehari – hari. Melalui model pembelajaran inkuiri terbimbing, peserta didik dapat mengembangkan aspek kognitif, afektif dan psikomotorik secara seimbang. Penelitian ini bertujuan untuk mengetahui apakah ada pengaruh model pembelajaran inkuiri terbimbing terhadap hasil belajar IPA peserta didik kelas V di SDN 1 Panarung. Penelitian ini menggunakan metode penelitian kuantitatif eksperimen dengan desain penelitian pretest – posttest control group design. Hasil penelitian ini menunjukkan bahwa terdapat pengaruh yang signifikan dalam penggunaan model pembelajaran inkuiri terbimbing terhadap hasil belajar IPA peserta didik kelas V SDN 1 Panarung dengan taraf signifikan < 0,05 atau 0,007 < 0,05.
Coubertin y la Carta Olímpica: un ejemplo de Constitución transnacional o soft-Constitución = Coubertin and the Olympic Chart: An example of transnational Constitution or Soft-Constitution
Authors: Muñiz Pérez Julio César 
Published: December 2022

Resumen: El movimiento olímpico manifiesta desde sus orígenes unos objetivos y unos valores que constituyen su razón de ser. En este trabajo se exponen los valores que inspiraron a Coubertin y a cuya promoción sirve el Movimiento Olímpico, así como su plasmación concreta en la Carta Olímpica. Esta plasmación en la Carta Olímpica se acompaña de un estudio sistemático de la evolución de la Carta y los valores en ella recogidos para determinar la vigencia del pensamiento de Coubertin en la misma, así como el planteamiento de su carácter de “Constitución transnacional”, junto a los retos de futuro que todavía se plantean. Abstract:The Olympic movement has manifested, since its origins, objectives and values that constitute its raison d'être. This paper presents the values that inspired Coubertin and whose promotion the Olympic Movement serves, as well as their concrete embodiment in the Olympic Charter. The Charter is accompanied by a systematic study of the evolution of the Charter and the values it embodies in order to determine the relevance of the Olympic Movement's values. The evolution of the Charter and the values contained therein to determine the relevance of Coubertin's thinking in the Charter, so its character as a "transnational Constitution”, as well as the challenges tofo the future that still remain.
The effect of balance, arm muscle strength, and coordination of batting skills cricket
Authors: Anggraeni Yulia , Pelana Ramdan , Hernawan  
Published: December 2022

This study aims to determine direct and indirect effects, and also the simultaneous effect of exogenous variables with endogenous variables. The research method is an associative quantitative approach, with test and measurement techniques. The data analysis technique uses a path analysis approach. In this study, The population is 60 athletes from the DKI Jakarta and Java cricket plate athletes. The sampling technique is total sampling. So, the number of samples in this study is 60 people consisting of 30 male athletes and 30 female athletes. Batting skills using the batting tee test. Balance using a balance test. Arm muscle strength using Pull and Push Dynamometer test, Coordination Instrument using Coordination test. The results of this study is the direct effect of variable X1 on Y = 0.271. The direct effect of variable X2 on Y = 0.478. The direct effect of variable X3 on Y = 0.216. The direct effect of variable X1 on X3 = 0.121. The direct effect of the X2 variable on X3 = 0.665. The indirect effect of variable X1 on Y through X3 = 0.121 x 0.216 = 0.026. The indirect effect of variable X2 on Y through X3 = 0.665 x 0.290 = 0.075.