bluuebunny/crossref_metadata_2025_split huggingface dataset:
‘Eyesight to the Blind’: Secular and Religious Dialogue in the ‘Devil's Music’
Authors: Curtis Bruce 
Published: November 2022

AbstractI adopt a dialogic approach to refute Paul Oliver’s claim that there is no challenge to the authority of the black Church or religion in the segregated ‘race records’ of the first half of the 20th century in the United States. I dismiss the claims of some black theologians that the presence of biblical imagery in the blues means that performers were essentially religious. I show that the dialogue between secular song and religious sermons on record involved mutual parody, satire, and polemic in a common speech genre. Attacks on the Church, its members, clergy, and doctrines were common. Recorded sermons spoke back in defense. Mikhail Bakhtin's concepts offer purchase on the relations between secular and religious recordings in an ongoing struggle for hegemony in black cultural production.
Quality‐of‐life outcomes following topical melatonin application against acute radiation dermatitis in patients with early breast cancer: A double‐blind, randomized, placebo‐controlled trial
Authors: Zetner Dennis , Kamby Claus , Gülen Sengül , Christophersen Camilla , Paulsen Cecilie B. , Piga Emily , Hoffmeyer Bodil , Mahmood Faisal , Rosenberg Jacob 
Published: November 2022

AbstractThe aim of this double‐blind, placebo‐controlled, randomized study was to investigate whether topical melatonin administered during radiation therapy could increase the quality of life in patients with primary breast cancer. Patients were followed from the first radiation fraction until 3 weeks after the last. The patients applied 1 g of cream to the irradiated area of the skin twice daily, consisting of either 25 mg/g melatonin and 150 mg/g dimethyl sulfoxide, or a placebo cream. Outcomes were the European Organisation for Research and Treatment of Cancer's quality‐of‐life questionnaires for breast cancer (QLQ‐C30 and QLQ‐BR23) on the last day of radiation therapy. As a secondary outcome, we evaluated the breast symptom (BS) scores over the entire duration of the trial in a repeated measures linear model. We included 65 patients and had 17 drop‐outs, thus totaling 26 and 22 patients in the melatonin and placebo groups, respectively. BS scores on the last day of radiation did not differ between groups (p = .333). However, the linear model analyzing BS for the entire duration showed that melatonin significantly decreased the symptoms (p = .001). There was no difference in the BS score on the last day of radiation, however, we found that the patients in the melatonin group had significantly lower BS scores over the entire duration of the trial.
The endogenous Coxiella burnetii plasmid encodes a functional toxin–antitoxin system
Authors: Wachter Shaun , Cockrell Diane C. , Miller Heather E. , Virtaneva Kimmo , Kanakabandi Kishore , Darwitz Benjamin , Heinzen Robert A. , Beare Paul A. 
Published: November 2022

AbstractCoxiella burnetii is the causative agent of Q fever. All C. burnetii isolates encode either an autonomously replicating plasmid (QpH1, QpDG, QpRS, or QpDV) or QpRS‐like chromosomally integrated plasmid sequences. The role of the ORFs present in these sequences is unknown. Here, the role of the ORFs encoded on QpH1 was investigated. Using a new C. burnetii shuttle vector (pB‐TyrB‐QpH1ori), we cured the C. burnetii Nine Mile Phase II strain of QpH1. The ΔQpH1 strain grew normally in axenic media but had a significant growth defect in Vero cells, indicating QpH1 was important for C. burnetii virulence. We developed an inducible CRISPR interference system to examine the role of individual QpH1 plasmid genes. CRISPRi of cbuA0027 resulted in significant growth defects in axenic media and THP‐1 cells. The cbuA0028/cbuA0027 operon encodes CBUA0028 (ToxP) and CBUA0027 (AntitoxP), which are homologous to the HigB2 toxin and HigA2 antitoxin, respectively, from Vibrio cholerae. Consistent with toxin–antitoxin systems, overexpression of toxP resulted in a severe intracellular growth defect that was rescued by co‐expression of antitoxP. ToxP inhibited protein translation. AntitoxP bound the toxP promoter (PtoxP) and ToxP, with the resulting complex binding also PtoxP. In summary, our data indicate that C. burnetii maintains an autonomously replicating plasmid because of a plasmid‐based toxin–antitoxin system.
A model of rational equilibrium in quota‐regulated multiple‐species fisheries
Authors: Singh Rajesh , Weninger Quinn 
Published: November 2022

AbstractThis paper derives rational ecological–economic equilibrium outcomes—capital and variable input allocations, harvests, discards, revenue, costs, and stock abundances—in a spatially heterogeneous, multispecies fishery that is regulated with individual fishing quotas (IFQs). The production setting is decentralized; a manager chooses species‐specific, seasonal, and spatially nondelineated quotas. Industry controls all aspects of harvesting operations. We present a solution concept and computational algorithm to solve for equilibrium harvests, discards, and profits across species, space, and time (within the regulatory cycle). The rational equilibrium mapping that we derive, used recursively, can be used to implement management‐preferred bioeconomic outcomes. The model offers an essential IFQ regulation‐to‐outcome mapping that enables more precise implementation of management goals in multiple‐species and heterogeneous fishery settings.Recommendations for Resource ManagersKnowing where and when individual tradeable fishing quotas will be utilized across heterogeneous space and time in multiple‐species fisheries is essential for effective fisheries management.Ad hoc models, while simple, contribute to “implementation uncertainty” whereby predicted mortality, discards, cost, and rent outcomes across fish species, space, and time are poorly matched to the realized outcomes that are implemented by resource users.A model of rational equilibrium mortality, discards, costs, and rent across space and time offers and powerful tool to improve the management of quota‐regulated fisheries.
The role of physical activity in the regulation of body weight: The overlooked contribution of light physical activity and sedentary behaviors
Authors: Bourdier Pierre , Simon Chantal , Bessesen Daniel H. , Blanc Stéphane , Bergouignan Audrey 
Published: November 2022

SummaryThe role of physical activity (PA) in the regulation of body weight is still a major topic of debate. This may be because studies have essentially focused on the effects of moderate/vigorous PA (MVPA) on body weight while overlooking the other components of PA, namely, light‐intensity PA (LPA, daily life activities) and sedentary behaviors (SB, too much sitting). In this review, we will (i) describe the history of changes in PA behaviors that occurred with modernization; (ii) review data from cross‐sectional and longitudinal studies that examined the associations between PA, SB, and measures of obesity; (iii) review interventional studies that investigated the effects of changes in PA and SB on body weight and adiposity; and (iv) discuss experimental studies that addressed potential biological mechanisms underlying the effects of PA and SB on weight regulation. Overall recent findings support the importance of considering all components of PA to better understand the regulation of energy balance and suggest an important role for LPA and SB in addition to MVPA on body weight regulation. Longitudinal large‐scale rigorous studies are needed to advance our knowledge of the role of PA/SB in combating the obesity epidemic.
Developing refractive management recommendations for patients undergoing cataract surgery: A Delphi study
Authors: Charlesworth Emily , Ursell Paul , Ho Kam Chun , Keay Lisa , Elliott David B. 
Published: November 2022

AbstractPurposeCurrently, there are no UK optometric guidelines regarding the pre and postoperative refractive management of patients undergoing cataract surgery. This study used a Delphi method to gain consensus on best practice.MethodsEighteen recommendations targeted areas of concern/variability in advice that were highlighted in an earlier focus group study of refractive management for patients who had received cataract surgery. These covered three topics: preoperative target refraction discussions, postoperative refractive management and driving advice postoperatively. The recommendations were then developed using evidence from optometry and ophthalmology clinical expertise and the research literature. Eighteen recommendations underwent a process of agreement and modification using a Delphi study consisting of a panel of 22 highly experienced optometrists (N = 11, 25 years mean clinical experience) and ophthalmologists (N = 11, 17 years mean clinical experience) who rated and commented upon the importance and feasibility of each recommendation. The responses were considered by the research team and the recommendations modified and/or removed prior to a second Delphi round of responses to a modified series of recommendations. Consensus of opinion was defined as greater than 80% of panellists ‘agreed’ or ‘strongly agreed’ on the recommendation for both importance and feasibility.ResultsFourteen of the 18 recommendations reached consensus in the first round. A second round of the Delphi method saw 17 modified recommendations scored and commented upon by 20 clinicians. Fifteen recommendations reached consensus after two rounds of the Delphi method.ConclusionsRecommendations to guide the pre and postoperative refractive management of patients undergoing cataract surgery were agreed between highly experienced optometrists and ophthalmologists using a 2‐round Delphi method. Patients would benefit from consistent target refraction discussions, postoperative refractive management and driving advice, and recommendations were of particular benefit to less experienced optometrists.
Risk Factors for the Drift Phenomenon in O‐arm Navigation‐Assisted Pedicle Screw Placement during Spinal Deformity Surgery
Authors: Zhao Jianquan , Jiang Heng , Zhuge Yingjie , Gao Rui , Wang Ce , Ma Jun , Zhou Xuhui 
Published: November 2022

ObjectiveIntraoperative O‐arm navigation systems improve the accuracy of spinal instrumentation placement. However, deviation of the pedicle screw from the guide line might occur. The aim of the present study was to explore the causes of and countermeasures for the drift phenomenon during pedicle screw implantation with the aid of an O‐arm three‐dimensional navigation system in spinal deformity surgery.MethodsThis was a retrospective analysis of 341 patients with spinal deformity who underwent O‐arm navigation system‐assisted pedicle screw placement from July 2015 to June 2019. The patient's general condition, Cobb angle, apical vertebra position, softness index, spinal release status, fixed reference frame position, and distance between the navigation vertebral body and the reference frame were collected and compared by independent‐samples t test or Pearson's chi‐square analysis. The potential risk factors for the drift phenomenon were identified using binary logistic regression analysis.ResultsThe drift phenomenon occurred in 57 patients during the first navigation‐assisted pedicle screw placement, for an incidence of 16.7% (57/341). There were significant differences in factors such as the apical vertebra position, softness index, spinal release status, and distance between the vertebral body and the reference frame when the drift phenomenon occurred (P < 0.05). Binary logistic regression analysis showed that the softness index, spinal release status, and distance between the vertebral body and the reference frame when drifting occurred were independent risk factors for the drift phenomenon during O‐arm navigation‐assisted pedicle screw placement.ConclusionDuring the use of an O‐arm navigation system to assist with pedicle screw placement, pedicle screws should not be placed away from the reference frame, and spinal osteotomy and release should be performed after pedicle screw placement. In addition, the accuracy of O‐arm navigation‐assisted pedicle screw placement will be affected more in those with larger softness indices.
Pathologic acne in pre‐pubertal children: A case series and review on when to refer to pediatric endocrinology
Authors: Shope Chelsea , Ritter Alexandra , Matlock Kristal , Wine Lee Lara 
Published: November 2022

AbstractAcne vulgaris is an extremely common chronic disease of the pilosebaceous unit. Despite its ubiquity, acne in the childhood years of approximately ages 1–6 years is exceedingly rare. Physicians should be suspicious of underlying systemic disease processes in patients of this age who present with onset of acne lesions, as pre‐pubertal acne in childhood has a distinctly different pathology than that of other age groups. Through a case series, we highlight the importance of a thorough work‐up and provide a review on when to refer to pediatric endocrinology to rule out precocious puberty and tumors as the cause of pre‐pubertal acne.
Cold stress triggers freezing tolerance in wheat (Triticum aestivum L.) via hormone regulation and transcription of related genes
Authors: Wang R. , Yu M. , Xia J. , Ren Z. , Xing J. , Li C. , Xu Q. , Cang J. , Zhang D. 
Published: November 2022

ABSTRACT
Low temperatures limit the geographic distribution and yield of plants. Hormones play an important role in coordinating the growth and development of plants and their tolerance to low temperatures. However, the mechanisms by which hormones affect plant resistance to extreme cold stress in the natural environment are still unclear.
In this study, two winter wheat varieties with different cold resistances, Dn1 and J22, were used to conduct targeted plant hormone metabolome analysis on the tillering nodes of winter wheat at 5 °C, −10 °C and −25 °C using an LC–ESI–MS/MS system. We screened 39 hormones from 88 plant hormone metabolites and constructed a partial regulatory network of auxin, jasmonic acid and cytokinin.
GO analysis and enrichment of KEGG pathways in different metabolites showed that the ‘plant hormone signal transduction’ pathway was the most common. Our study showed that extreme low temperature increased the most levels of auxin, cytokinin and salicylic acid, and decreased levels of jasmonic acid and abscisic acid, and that levels of auxin, jasmonic acid and cytokinin in Dn1 were higher than those in J22. These changes in hormone levels were associated with changes in gene expression in synthesis, catabolism, transport and signal transduction pathways. These results differ from the previous hormone regulation mechanisms, which were mostly obtained at 4 °C.
Our results provide a basis for further understanding the molecular mechanisms by which plant endogenous hormones regulate plant freezing stress tolerance.
Empirical Likelihood-Based Inference for Functional Means with Application to Wearable Device Data
Authors: Chang Hsin-wen , McKeague Ian W. 
Published: November 2022

AbstractThis paper develops a nonparametric inference framework that is applicable to occupation time curves derived from wearable device data. These curves consider all activity levels within the range of device readings, which is preferable to the practice of classifying activity into discrete categories. Motivated by certain features of these curves, we introduce a powerful likelihood ratio approach to construct confidence bands and compare functional means. Notably, our approach allows discontinuities in the functional covariances while accommodating discretization of the observed trajectories. A simulation study shows that the proposed procedures outperform competing functional data procedures. We illustrate the proposed methods using wearable device data from an NHANES study.
The interplay between gastrocnemius medialis force–length and force–velocity potentials, cumulative EMG activity and energy cost at speeds above and below the walk to run transition speed
Authors: Monte Andrea , Tecchio Paolo , Nardello Francesca , Bachero‐Mena Beatriz , Ardigò Luca Paolo , Zamparo Paola 
Published: November 2022

AbstractThe aim of this study was to investigate the interplay between the force–length (F–L) and force–velocity (F–V) potentials of gastrocnemius medialis (GM) muscle fascicles, the cumulative muscle activity per distance travelled (CMAPD) of the lower limb muscles (GM, vastus lateralis, biceps femori, tibialis anterior) and net energy cost (Cnet) during walking and running at speeds above and below the walk‐to‐run transition speed (walking: 2–8 km h−1; running: 6–10 km h−1). A strong association was observed between Cnet and CMAPD: both changed significantly with walking speed but were unaffected by speed in running. The F–L and F–V potentials decreased with speed in both gaits and, at 6–8 km h−1, were significantly larger in running. At low to moderate walking speeds (2–6 km h−1), the changes in GM force potentials were not associated with substantial changes in CMAPD (and Cnet), whereas at walking speeds of 7–8 km h−1, even small changes in force potentials were associated with steep increases in CMAPD (and Cnet). These data suggest that: (i) the walk to run transition could be explained by an abrupt increase in Cnet driven by an upregulation of the EMG activity (e.g., in CMAPD) at sustained walking speeds (>7 km h−1) and (ii) the reduction in the muscle's ability to produce force (e.g., in the F–L and F–V potentials) contributes to the increase in CMAPD (and Cnet). Switching to running allows regaining of high force potentials, thus limiting the increase in CMAPD (and Cnet) that would otherwise occur to sustain the increase in locomotion speed.
Design of Structure Parameters of Sliding Vane Pump Based on Lifting Characteristics
Authors: Wang Shuolong , Cao Nai , Zhang Anlei , Zhao Xiangyang , Fan Zhuoying , Chen Yashu , Wang Lei , Niu Chengcheng 
Published: November 2022

Abstract
Limited by the harsh downhole working environment and its structural feature, the sliding vane pump (SVP), which is an all-metal artificial lift method considered to be widely used in thermal recovery well and high gas/oil ratio well, has not been widely applied as expected. To further improve the efficiency of SVP, this study explores how to optimize the structure parameters and the usage of the pump based on its lifting characteristics, in view of the stagnation in the development of SVP. The main results show that (a) optimization of the inlet (outlet) position parameters will bring effective pre-expansion (precompression) of each chamber once it enters the closed state, to avoid ineffective suction and high-pressure backflow. (b) The mathematical model of the pressure difference between the two sides of the vane at any position is derived by means of piecewise function. (c) Increasing the number of vanes can not only increase the mean value of instantaneous displacement but also shorten the discharge period and reduce the flow pulsation. Compared with the adjacent even number of vanes, the odd number of vanes has a more uniform instantaneous displacement. (d) A larger cross-sectional area of the rotor groove can result in a lower volume efficiency at the same gas–liquid ratio, and the effect of rotor groove on volume efficiency is more significant under high gas–liquid ratio conditions.
Research on Strengthening Mechanism of Rare Earth Cemented Carbide Tool Material
Authors: Hao Zhaopeng , Qiu Yuan , Fan Yihang 
Published: November 2022

Abstract
In this paper, the first principle method based on density functional theory is adopted to establish the interface model of WC/WC-Co through the software Materials Studio (MS). On the basis of this interface structure, rare earth element Y is doped, and then the energy of WC/WC-Co before and after doping is calculated respectively. The electronic structure is analyzed, and the calculation results of the two structures are compared. Finally, the grain growth is simulated by cellular automata of matlab to verify our calculation and analysis results. The results show that the interfacial adhesion work increases and the interface structure is more stable after doping Y element. The interface energy decreases and plays a role in grain refinement.
On the Feasibility of Using an Ultra-Fast DirectMS1 Method of Proteome-Wide Analysis for Searching Drug Targets in Chemical Proteomics
Authors: Solovyeva Elizaveta M. , Bubis Julia A. , Tarasova Irina A. , Lobas Anna A. , Ivanov Mark V. , Nazarov Alexey A. , Shutkov Ilya A. , Gorshkov Mikhail V. 
Published: November 2022

Abstract
Protein quantitation in tissue cells or physiological fluids based on liquid chromatography/mass spectrometry is one of the key sources of information on the mechanisms of cell functioning during chemotherapeutic treatment. Information on significant changes in protein expression upon treatment can be obtained by chemical proteomics and requires analysis of the cellular proteomes, as well as development of experimental and bioinformatic methods for identification of the drug targets. Low throughput of whole proteome analysis based on liquid chromatography and tandem mass spectrometry is one of the main factors limiting the scale of these studies. The method of direct mass spectrometric identification of proteins, DirectMS1, is one of the approaches developed in recent years allowing ultrafast proteome-wide analyses employing minute-scale gradients for separation of proteolytic mixtures. Aim of this work was evaluation of both possibilities and limitations of the method for identification of drug targets at the level of whole proteome and for revealing cellular processes activated by the treatment. Particularly, the available literature data on chemical proteomics obtained earlier for a large set of onco-pharmaceuticals using multiplex quantitative proteome profiling were analyzed. The results obtained were further compared with the proteome-wide data acquired by the DirectMS1 method using ultrashort separation gradients to evaluate efficiency of the method in identifying known drug targets. Using ovarian cancer cell line A2780 as an example, a whole-proteome comparison of two cell lysis techniques was performed, including the freeze-thaw lysis commonly employed in chemical proteomics and the one based on ultrasonication for cell disruption, which is the widely accepted as a standard in proteomic studies. Also, the proteome-wide profiling was performed using ultrafast DirectMS1 method for A2780 cell line treated with lonidamine, followed by gene ontology analyses to evaluate capabilities of the method in revealing regulation of proteins in the cellular processes associated with drug treatment.