bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cancer statistics forAmericanIndian andAlaskaNative individuals, 2022: Including increasing disparities in early onset colorectal cancer
Authors: Kratzer Tyler B. , Jemal Ahmedin , Miller Kimberly D. , Nash Sarah , Wiggins Charles , Redwood Diana , Smith Robert , Siegel Rebecca L. 
Published: November 2022

AbstractAmerican Indian and Alaska Native (AIAN) individuals are diverse culturally and geographically but share a high prevalence of chronic illness, largely because of obstacles to high‐quality health care. The authors comprehensively examined cancer incidence and mortality among non‐Hispanic AIAN individuals, compared with non‐Hispanic White individuals for context, using population‐based data from the National Cancer Institute, the Centers for Disease Control and Prevention, and the North American Association of Central Cancer Registries. Overall cancer rates among AIAN individuals were 2% higher than among White individuals for incidence (2014 through 2018, confined to Purchased/Referred Care Delivery Area counties to reduce racial misclassification) but 18% higher for mortality (2015 through 2019). However, disparities varied widely by cancer type and geographic region. For example, breast and prostate cancer mortality rates are 8% and 31% higher, respectively, in AIAN individuals than in White individuals despite lower incidence and the availability of early detection tests for these cancers. The burden among AIAN individuals is highest for infection‐related cancers (liver, stomach, and cervix), for kidney cancer, and for colorectal cancer among indigenous Alaskans (91.3 vs. 35.5 cases per 100,000 for White Alaskans), who have the highest rates in the world. Steep increases for early onset colorectal cancer, from 18.8 cases per 100,000 Native Alaskans aged 20–49 years during 1998 through 2002 to 34.8 cases per 100,000 during 2014 through 2018, exacerbated this disparity. Death rates for infection‐related cancers (liver, stomach, and cervix), as well as kidney cancer, were approximately two‐fold higher among AIAN individuals compared with White individuals. These findings highlight the need for more effective strategies to reduce the prevalence of chronic oncogenic infections and improve access to high‐quality cancer screening and treatment for AIAN individuals. Mitigating the disparate burden will require expanded financial support of tribal health care as well as increased collaboration and engagement with this marginalized population.
Long term Cardiovascular Manifestations of COVID - 19
Authors: Ahmed Khurshed , Sah Sudhir Prasad , Khaled Md Fakhrul Islam , Anwar AFM Azim , Hoque Md Harisul 
Published: November 2022

Although severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is well known for causing an acute respiratory disease, a number of patients after they get recovered from acute infection, subsequently experience a constellation of symptoms and events that lasts for more than 3 months. Adequate clinical data are now accumulating on the subacute and long-term effects of Covid-19 and can involve multiple organ systems. This spectrum of symptoms and late manifestations are thought to have a possible link with the covid-19 and this condition is named LONG COVID or POST-COVID. Some of the patients may show the ongoing evidence of cardiovascular damage on long term without having symptoms which may be picked up by different imaging modalities like CMR. There has been an increase in the number of COVID-19 patients in an exponential fashion so as to cause a collapse in the healthcare system in many countries across the world, with an effect not only on public health, but also on social and economic activities.
University Heart Journal 2022; 18(2): 118-124
Pengembangan Media Maze Kotaku untuk Menstimulasi Kemampuan Memecahkan Masalah pada Anak Usia 4-5 Tahun
Authors: Lestariningrum Anik , Niken Ayu Saptiwi  
Published: November 2022

Tahapan berpikir pra-operasional merupakan saat anak-anak membutuhkan sebuah media pembelajaran yang dapat menggabungkan pola pikir sederhana terutama dalam kemampuan mencari solusi dari masalah yang dihadapi. Anak terbiasa dengan bimbingan dan pendampingan yang sangat ketat dari orang dewasa disekitarnya membuat tidak memiliki kebebasan menentukan pilihan sendiri. Permasalahan ini dihadapi oleh anak di lembaga PAUD Darussalam Jabon dari 13 anak capaian kognitif terkait kemampuan memecahkan masalah hanya 4 anak yang memperoleh BSH sedangkan 2 anak dalam kategori MB dan 7 anak BB. Analisis kebutuhan dilakukan ditemukan kebutuhan media pembelajaran yang perlu diinovasi sehingga dapat menumbuhkan minat anak mencapai kemampuan memecahkan masalah sederhana. Desain penelitian adalah R & D dengan mengadopsi Borg & Gall yang digunakan hanya sampai 4 tahapan dengan keterbatasan penelitian dimiliki yaitu potensi masalah, pengumpulan data, desain produk dan validasi desain. Hasil penelitian yang diharapkan adalah prototype terkait desain dan panduan media pembelajaran maze kotaku yang akan digunakan dalam pengembangan kemampuan kognitif anak fokus pemecahan masalah. Diharapkan desain hasil produk yang divalidasi nantinya dapat digunakan dalam tahapan selanjutnya.
Kata Kunci: memecahkan masalah, maze kotaku, anak usia 4-5 tahun.
PENERAPAN PROBLEM BASED LEARNING DALAM MENINGKATKAN KEMAMPUAN BERPIKIR KRITIS SISWA MA NEGERI 1 KOTA BENGKULU
Authors: Malinda Guspita 
Published: November 2022

dengan dua siklus. Setiap siklus teridi dari empat tahapan, yaitu: (1) perencanaan, (2) pelaksanaan, (3) pengamatan, dan (4) refleksi. Subjek penelitian adalah siswa kelas XI IPS 2 MA Negeri 1 Kota Bengkulu tahun ajaran 2018/2019 dengan jumlah sebanyak 24 orang siswa. Teknik pengumpulan data dilakukan dengan tes. Instrumen penelitian terdiri dari lembar tes berpikir kritis dan lembar obeservasi. Hasil peneltian diperoleh kesmpulan bahwa penerapan model problem based learning dapat meningkatkan kemampuan berpikir kritis siswa. Hal ini ditunjukkan adanya peningkatan pada setiap siklus. Pada siklus I dengan nilai rata-rata 60,05 dan ketuntasan belajar 62,50% dan meningkat pada siklus II dengan nilai rata-rata 74,50 dan ketuntasan belajar 79,16%. Peningkatan dengan melakukan beberapa tindakan: (a) menyiapkan masalah nyata pada awal pembelajaran, (b) menyiapkan bahan ajar berupa LKS, (c) membentuk kelompok kecil dalam pembelajaran.
PEMBERDAYAAN KELOMPOK NELAYAN MELALUI PROGRAM SENTRA KELAUTAN DAN PERIKANAN TERPADU (SKPT) DI KABUPATEN MALUKU BARAT DAYA
Authors: Dewi Mutiar Fitri , Dadiara Frans Simon 
Published: November 2022

Indonesia's fisheries potential has an essential and strategic role for the national development since it influences economic, security, ecological and social aspects. With this important role, it is assumed that the living standard of Indonesia’s fishermen improved. However, based on the data from the Ministry of Maritime Affairs (2018), most Indonesia’s fishermen still live within the poverty line. This current study aims at describing the implementation of fishermen group empowerment through integrated marine and fisheries center program in Maluku Barat Daya District. The data of this study are gathered through direct observation, in-depth interview and documentation study. Then they are analyzed based on Empowerment theory by Mardikanto and Soebiato (2017). The study’s result show that the empowerment emerged in three aspects namely human, business, and institutional development. It is also found that the empowerment process is still not optimal due to several obstacles namely lack of awareness of fishermen group, characteristics of the archipelago, and inadequate communication network. To overcome these, the Fishery Department has made efforts such as giving training, distributing fishing gears, and establishing certain fishermen groups. Suggestions given by the authors are giving self-awareness and work ethics socialization, cooperating with the heads of village, and issuing local government regulation regarding fishery.

Keywords: Empowerment, Fishermen Group, Integrated Marine and Fisheries Center Program
Initial experience with pulsed field ablation for atrial fibrillation
Authors: Magni Federico T. , Mulder Bart A. , Groenveld Hessel F. , Wiesfeld Ans C. P. , Tieleman Robert G. , Cox Moniek G. , Van Gelder Isabelle C. , Smilde Tom , Tan Eng S. , Rienstra Michiel , Blaauw Yuri 
Published: November 2022

IntroductionPulsed field ablation (PFA) was recently introduced for the treatment of symptomatic atrial fibrillation (AF) with the claim of selectively ablating the myocardium while sparing surrounding tissues. We present our initial experience with a PFA catheter for pulmonary vein isolation (PVI) and describe procedural findings and peri-procedural safety of the first 100 patients.Materials and methodsWe investigated 100 patients treated for symptomatic AF using the FARAWAVE PFA catheter (Farapulse, Menlo Park, CA, USA) between July 2021 and March 2022. Procedure workflow and electrophysiological findings at the time of ablation, peri-procedural complications, and operator learning curves are described.ResultsThe mean age of patients was 62.9 ± 9.4 years, 62% were male subjects and 80% had paroxysmal AF. The median CHA2DS2-VASc score was 1.5 (IQR: 1.0–2.0) and the mean left atrial volume index was 35.7 ± 9.6 ml/m2. In 88 (88%) patients, PVI alone was performed and in 12 (12%) patients additional ablation of the posterior wall was performed. 3D-electroanatomic mapping was performed in 18 (18%) patients. Procedures without mapping lasted for 52.3 ± 16.6 min. The mean number of applications per pulmonary vein (PV) was 8.1 ± 0.6. In all patients (100%), all PVs were confirmed to be isolated. The learning curves of the two operators who performed &gt; 20 procedures showed a negligible variation of performance over time and practice did not significantly predict procedure time [Operator 1 (senior): R2 = 0.034, p = 0.35; Operator 2 (junior): R2 = 0.004, p = 0.73]. There was no difference between the procedure times between senior and junior operators (Operator 1: 46.9 ± 9.7 min vs. Operator 2: 45.9 ± 9.9 min; p = 0.73). The only complications observed were two cases of bleeding at the site of percutaneous access.ConclusionOur initial experience shows that use of the PFA catheter for pulmonary vein isolation (PVI) is safe, fast, and easy to learn.
Real-world intravascular ultrasound (IVUS) use in percutaneous intervention-naïve patients is determined predominantly by operator, patient, and lesion characteristics
Authors: Tindale Alexander , Panoulas Vasileios 
Published: November 2022

BackgroundIntravascular Ultrasound (IVUS) has been shown to improve clinical outcomes in patients undergoing percutaneous intervention (PCI) in numerous trials. However, it is still underutilized outside of trial settings, and most trials include a significant proportion of patients with prior PCI. The aim of this study is to look at real-world use and outcomes in PCI-naïve patients who undergo IVUS-guided intervention.Methods and resultsProspectively collected data from 10,574 consecutive patients undergoing their index PCI was retrospectively analyzed. 455 (4.3%) patients underwent IVUS, with a median follow-up of 4.6 years. Patients undergoing IVUS had higher levels of comorbidities including diabetes (27.5% vs. 19.7%, p &lt; 0.001), hypertension (58.0% vs. 47.9%, p &lt; 0.001), hypercholesterolemia (51.6% vs. 39.2%, p &lt; 0.001) and were generally older (65.9 ± 14.5 vs. 64.5 ± 13.4 years, p = 0.031) with higher mean baseline creatinine levels (95.4 ± 63.3 vs. 87.8 ± 46.1 μmol/L). The strongest predictor of IVUS use was the operating consultant graduating from medical school after the year 2000 [OR 14.5 (3.5–59.8), p &lt; 0.001] and the presence of calcific lesions [OR 5.2 (3.4–8.0) p &lt; 0.001]. There was no significant difference in MACE nor 1-year mortality between patients undergoing IVUS-guided or angiography-only PCI on unadjusted analysis [OR 1.04 (0.73—1.5), p = 0.81, OR 1.055 (0.65–1.71) p = 0.828] nor mortality throughout the study period (HR 0.93 (0.69—1.26), p = 0.638). This held true for stents longer than 28 mm. Propensity matched analysis of patients similarly showed no mortality difference between arms for all patients and those with longer stents (p = 0.564 and p = 0.919).ConclusionThe strongest predictors of IVUS use in PCI-naïve patients are the operator’s year of graduation from medical school and proxy measures of calcific lesions. On both matched and adjusted analysis there was no evidence of improved mortality nor reduced MACE in this specific retrospective cohort, although this may well be explained by significant selection bias.
In situ repair or reconstruction of the abdominal aorta-iliac artery by autologous fascia-peritoneum with posterior rectus sheath for the treatment of the infected abdominal aortic and iliac artery aneurysms: A case series and literature review
Authors: Li Lubin , Liu Guolong , Yu Benxiang , Niu Wenqiang , Pei Zhigang , Zhang Juwen , Che Haijie , Song Fubo , Yang Mu 
Published: November 2022

BackgroundInfected abdominal aortic and iliac artery aneurysms are considered acute and severe diseases with insidious onset, rapid development, and high mortality in vascular surgery. Currently, there is no better treatment, either anatomic or extra-anatomical repair.Case presentationFrom February 2018 to April 2022, 7 patients with infected abdominal aortic and iliac artery aneurysms did not have sufficient autologous venous material for repair. With the consent of the Ethics Committee of the hospital, it uses the autologous peritoneal fascial tissue with rectus sheath to repair or reconstruct the infected vessels in situ. There were 5 cases of infected abdominal aortic aneurysm, 1 case of an infected common iliac aneurysm, and 1 case of the infected internal iliac aneurysm. Aortoduodenal fistula was found in 3 cases, all of them were given duodenal fistula repair and gastrojejunostomy and cholecystostomy. Three cases of infected abdominal aortic aneurysms were repaired with the autologous peritoneal fascial tissue patch, and 2 cases of infected abdominal aortic aneurysms were reconstructed by the autologous peritoneal fascial tissue suture to bifurcate graft in situ, the autologous peritoneal fascial tissue suture reconstructed the rest 2 cases of infected iliac aneurysm to tubular graft in situ. It was essential that Careful debridement of all infected tissue and adequate postoperative irrigation and drainage. Antibiotics were administered perioperatively, and all patients were subsequently treated with long-term antibiotics based on bacterial culture and susceptibility results of infected tissues and blood. All 7 patients had underwent surgery successfully. But there were 2 cases died of anastomotic infection or massive hemorrhage after the operation, the other 5 cases survived. The follow-up time was 2–19 months. The enhanced CT of postoperation showed that the reconstructed arteries were smooth without obvious stenosis or expansion, and no abdominal wall hernia occurred.ConclusionIn situ repair or reconstruction with autologous peritoneal fascial tissue with rectus sheath is a feasible treatment for the infected aneurysm patients without adequate autologous venous substitute, but it still needs long-term follow-up and a large sample to be further confirmed.
Analysis of blood lipid changes and influencing factors in physical examination population of a city in central China
Authors: Zhu Boya , Wang Wenjing , Li Mengying , Peng Shuzhen , Tan Xiaodong 
Published: November 2022

PurposeThe prevalence of cardiovascular diseases (CVDs) associated with lipid levels is increasing worldwide. Our purpose is to analyze the distribution level and influencing factors of lipid in the whole population and to put forward suggestions for preventing abnormal lipid levels.MethodsThe study was based on a sample of 91,480 Chinese who participated in a nationwide physical examination program in Wuhan, a midland city in China, in 2018. The distribution of blood lipid in the population was observed using average, and the relationship between the influencing factors and blood lipid level was observed by quantile regression (QR).ResultsA total of 91,480 people were evaluated in this study, among which 59,165 (64.68%) were female with a mean age of 51.71 ± 10.82 years. QR results showed that different physical examination indexes had different effects on lipid levels. Fasting plasma glucose (FBG) has the largest QR coefficient and BMI had positive effects on total cholesterol (TC), triglyceride (TG), and low-density lipoprotein cholesterol (LDL-C). In males, age has a positive influence on TC, LDL-C, and high-density lipoprotein cholesterol (HDL-C), while in females, age has a positive influence on all four indexes.ConclusionWe found that the TC and LDL-C levels of females were more susceptible to age than males, and the lipid levels of older females were higher than males. BMI has a greater effect on lipid levels in males than in females. Regardless of gender should pay attention to dyslipidemia caused by diabetes and abnormal liver function.
Unsupervised mobile app-based cognitive testing in a population-based study of older adults born 1944
Authors: Öhman Fredrik , Berron David , Papp Kathryn V. , Kern Silke , Skoog Johan , Hadarsson Bodin Timothy , Zettergren Anna , Skoog Ingmar , Schöll Michael 
Published: November 2022

BackgroundMobile app-based tools have the potential to yield rapid, cost-effective, and sensitive measures for detecting dementia-related cognitive impairment in clinical and research settings. At the same time, there is a substantial need to validate these tools in real-life settings. The primary aim of this study was thus to evaluate the feasibility, validity, and reliability of mobile app-based tasks for assessing cognitive function in a population-based sample of older adults.MethodA total of 172 non-demented (Clinical Dementia Rating 0 and 0.5) older participants (aged 76–77) completed two mobile app-based memory tasks—the Mnemonic Discrimination Task for Objects and Scenes (MDT-OS) and the long-term (24 h) delayed Object-In-Room Recall Task (ORR-LDR). To determine the validity of the tasks for measuring relevant cognitive functions in this population, we assessed relationships with conventional cognitive tests. In addition, psychometric properties, including test-retest reliability, and the participants’ self-rated experience with mobile app-based cognitive tasks were assessed.ResultMDT-OS and ORR-LDR were weakly-to-moderately correlated with the Preclinical Alzheimer's Cognitive Composite (PACC5) (r = 0.3–0.44, p &lt; .001) and with several other measures of episodic memory, processing speed, and executive function. Test-retest reliability was poor–to-moderate for one single session but improved to moderate–to-good when using the average of two sessions. We observed no significant floor or ceiling effects nor effects of education or gender on task performance. Contextual factors such as distractions and screen size did not significantly affect task performance. Most participants deemed the tasks interesting, but many rated them as highly challenging. While several participants reported distractions during tasks, most could concentrate well. However, there were difficulties in completing delayed recall tasks on time in this unsupervised and remote setting.ConclusionOur study proves the feasibility of mobile app-based cognitive assessments in a community sample of older adults, demonstrating its validity in relation to conventional cognitive measures and its reliability for repeated measurements over time. To further strengthen study adherence, future studies should implement additional measures to improve task completion on time.
Maternal diabetes and the role of neonatal reticulocyte hemoglobin content as a biomarker of iron status in the perinatal period
Authors: Babacheva Evgeniya , Rallis Dimitrios , Christou Helen , Mitsiakos George , Mikos Themistoklis , Dampala Kalliopi , Tsakalidis Christos , Kioumi Anna , Goulis Dimitrios G. , Soubasi Vasiliki 
Published: November 2022

AimsWe aimed to evaluate the effects of maternal diabetes on neonatal iron status, measuring erythrocyte indices including hemoglobin, hematocrit, reticulocytes, mean corpuscular volume (MCV), percent (%) hypochromia, ferritin, and additionally mean reticulocyte hemoglobin content (MCHr) as an early marker of iron deficiency, and examine the association between neonatal MCHr, red cell indices, and ferritin.Materials and MethodsWe conducted a hospital-based prospective cohort study in a tertiary neonatal unit of a University Hospital from 2018 to 2020. We enrolled 126 maternal-infant pairs of mothers whose pregnancy was associated with diabetes and 74 maternal-infant pairs from uncomplicated pregnancies. Erythrocyte indices were analyzed within the first twelve hours after birth. Erythrocyte parameters were compared between infants of the diabetes and the non-diabetic group. We examined the correlation of the neonatal MCHr with perinatal characteristics, including gestation, birth weight, maternal body mass index, the erythrocytic indices, maternal diabetes, maternal obesity, prematurity, small-for-gestational-age status, maternal preeclampsia, and maternal anemia. Finally, we evaluated the discordance between neonatal MCHr and neonatal ferritin.ResultsInfants of the diabetes group had a significantly lower MCHr (32.6 pg vs. 34.2 pg, p=0.003) compared with infants of uncomplicated pregnancies. Neonatal MCHr was significantly correlated with maternal hypochromia (r=-0.237, p=0.004) and neonatal MCV (r=0.674, p&lt;0.001). Neonatal MCHr was significantly associated with maternal diabetes [standardized coefficients 0.21, 95% confidence interval (CI) 0.05-0.58, p=0.003) and maternal preeclampsia (standardized coefficients 0.17, 95% CI 0.02-0.92, p=0.019), after adjusting for maternal anemia, maternal obesity, prematurity, and small-for-gestational-age status. Those results were consistent also when analyzing maternal-infant pairs with pre-existing diabetes, and maternal-infant pairs with gestational diabetes. There was significant discordance between neonatal MCHr and neonatal ferritin (p=0.001).ConclusionsMCHr was significantly lower in infants of mothers whose pregnancy was associated with diabetes compared with infants of non-diabetic mothers and correlated with neonatal and maternal red cell indices of iron deficiency. Since there was significant discordance between neonatal MCHr and ferritin during the first postnatal day, it is possible that MCHr could be used as a screening test for iron deficiency, especially in infants.