bluuebunny/crossref_metadata_2025_split huggingface dataset:
Incidência de micro-organismos resistentes pós síndrome respiratória da COVID-19: Uma revisão integrativa
Authors: Arthur Eduarda Faria , Moizes Marciany Aparecida Fragoso , Gonzaga Rafaela Rodrigues , Venckunas Luciana Simi , Silva Beatriz Franco e , Palma Ana Luiza do Rosário 
Published: August 2022

Este estudo, objetivou a analisar a incidência de resistência bacteriana pós infecção por COVID-19. Para a realização dessa revisão de literatura do tipo integrativa, tomou-se como base de estudo: Incidência de resistência bacteriana pós infecção por COVID. Foi realizado o levantamento dos artigos na literatura, para esta revisão, nas bases de dados: LILACS, BVS (biblioteca virtual em saúde), PubMed e Scielo. Foram utilizados, para busca dos artigos, as seguintes palavras-chave e suas combinações nas línguas portuguesa e inglesa: “COVID-19”, “resistência bacteriana” e “coinfecção”. Todas as palavras foram previamente consultadas nos Descritores em Ciências da Saúde (Decs). O levantamento ocorreu entre os meses de abril a junho de 2022. A predisposição para o desenvolvimento de bactérias e fungos está se mostrando evidente em pacientes que contraíram o coronavírus. Pacientes com COVID-19 possuem dimensões relatadas de complicações, incluindo síndrome do desconforto respiratório, taxas de letalidade ou outras variáveis associadas a essas complicações. Dentre as doenças pós síndrome respiratória da COVID-19, foram encontrados estudos de caso de endocardite infecciosa de prótese valvar mitral, endocardite infecciosa da válvula nativa, endoftalmite bilateral, endocardite infecciosa mitroaórtica complicada por insuficiência cardíaca e acidente vascular cerebral hemorrágico, mucormicoses, síndrome inflamatória multissistêmica pediátrica e linfocitopenia em pacientes com talassemia. São relatos recentes, e ainda são necessários mais estudos para correlacionar a dimensão da gravidade da influência do COVID-19 com a resistência bacteriana. Concluímos que co-infecções com vários micro-organismos são comumente encontradas em pacientes infectados por SARS-CoV-2 que influenciam significativamente a gravidade e taxas de mortalidade por COVID-19.
SURVEY ON THE EXISTENCE OF THE INFORMAL SECTOR DURING THE COVID-19 PANDEMIC (Case Study In Mataram City, West Nusa Tenggara Province)
Authors: Suprianto Suprianto , Agustiani Eka , Alwi Mohammad 
Published: August 2022

The purpose of this research is to The purpose of the study was to analyze the income and welfare level of informal sector workers during the Covid-19 pandemic in the city of Mataram. The research method was carried out by means of a survey by taking a sample of 60 respondents, and as many respondents as possible were determined by chance by looking at the characteristics of the informal sector workers. The data collected will be analyzed quantitatively and qualitatively. Qualitative analysis is used to explain or explain data from field research as a support for quantitative analysis. The characteristics of informal and formal workers mostly sell in crowded places with dense population and visitors in the area of Mataram city seen from the level of education 56.7% have education equivalent to high school and above and 43.3% have graduated from junior high and elementary school with an average the average length of work is more than 10 hours a day, while the average family dependents for informal and formal workers are between 2 and 4 dependents. The average income earned by informal workers is below Rp 2,000,000, - as many as 25 respondents, 41.67% and income above Rp 2,000,000, - for 20 respondents or 33.33%. While the income of informal workers on average is above IDR 3,000,000, as many as 11 respondents, 18.33%, the rest of the income above IDR 5,000,000, as many as 4 respondents or 6.67% is obtained by fried rice traders and food stalls.total income analysis of informal workers if according to the Sajogyo criteria level with an equivalent size, then the poor category is 68.33% with an expenditure / capita / year of 450 kg - 650 kg equivalent to the value of rice / year. While the remaining 31.67% or as many as 19 respondents are at the threshold of affluent living with per capita expenditures / year above 750 kg as many as 9 respondents. While the decent living category if the competition per capita / year is higher than 960 kg equivalent to the value of rice / year as many as 10 respondents or 16.67%. Overall, the income received by informal workers during the Covid-19 pandemic decreased by 40% compared to before the Covid-19 pandemic. To further increase the income of informal workers, in particular, to increase the working time of at least 15 hours per day and to open sales services through social media (medsos) with a digital system via the internet with Go food and Go-jek services, especially for traders of cooked food such as restaurants, fresh vegetables, rice and beverage traders.
THE EFFECT OF EDMODO – BASED BLENDED LEARNING ON ACCOUNTING LEARNING OUTCOMES VIEWED SELF REGULATED LEARNING
Authors: Satiti Abidah Dwi Rahmi , Fibriyanti Yenni Vera 
Published: August 2022

The objective of this research was to investigate the difference effect between the Edmodo - Based Blended Learning and the conventional learning on accounting learning outcomes viewed self regulated learning. This research was an quasi experimental with nonequivalent pretest posttest control-group design. The population of research was the students in semester 4 of classes A, B, and C. The research sample was taken 2 classes, namely class B and class C. The data were analyzed by using the two-way analysis of variance and was continued with the Scheffe test. The findings showed that: (1) there was a difference effect between the Edmodo –Based Blended Learning on accounting learning outcomes; (2) there was a difference effect of the high, moderate, and low self regulated learning on accounting learning outcomes; and (3) there was not an interaction between the Edmodo – Based Blended Learning and the conventional learning with self regulated learning on accounting learning outcomes.
Ship wake forcing and performance of a living shoreline segment on an estuarine shoreline
Authors: Everett Cassandra L. , Williams Oscar , Ruggiero Emma , Larner Michael , Schaefer Rachel , Malej Matt , Shi Fengyan , Bruck Jules , Puleo Jack A. 
Published: August 2022

Investigation of the effectiveness of Natural and Nature-Based Features (NNBF) for protecting shorelines from ship wake is increasingly important with continued development along the coast, especially when combined with sea level rise. Studies that investigate the wave energy dissipation capacity of different techniques and account for variation in context will lead to improvements and innovation in designed NNBF. Few studies have examined the performance of NNBF in protecting shorelines from ship wake. In this study of a low-sloping estuarine shoreline adjacent to a major shipping route, a natural design using coir logs and wooden staking was implemented in a T-head groin configuration. Pressure transducers and electromagnetic current meters were deployed over ∼1.5 months to investigate the energy dissipation and velocity attenuation capabilities of the installation. Results indicate that ship wakes account for 25%–50% of the total daily energy impacting the shoreline at the study site. Peak background velocities are typically over 50% smaller than the largest ship wake velocities. Field data and results of the fully nonlinear Boussinesq model, FUNWAVE-TVD, indicate that the installation is capable of decreasing energy impacting the shoreline by 10%–80% and is effective over the lower 50% of the tidal range and when submerged up to twice its height. Elevation surveys of the site indicate accrual of sediment within the installation, suggesting wave diffraction patterns promoting further accretion at the site over time. Observations indicate that coir logs may be effective in reducing wave energy from ship wakes but may fail under storm conditions in a moderate fetch confined channel. Findings from this study illustrate the opportunities and challenges nature-based solutions face in addressing ship wakes, and their ability to protect shorelines under high energy stressors.
Integrated network pharmacology and hepatic metabolomics to reveal the mechanism of Acanthopanax senticosus against major depressive disorder
Authors: Gu Xinyi , Zhang Guanying , Wang Qixue , Song Jing , Li Ying , Xia Chenyi , Zhang Ting , Yang Li , Sun Jijia , Zhou Mingmei 
Published: August 2022

Objective:Acanthopanax senticosus(Rupr. et Maxim.) Harms (ASH) is a traditional herbal medicine widely known for its antifatigue and antistress effects, as well as tonifying qi, invigorating spleen and kidney, and tranquilizing the mind. Recent evidence suggests that ASH has a therapeutic effect on major depressive disorder (MDD), but its mechanism is still unclear. The current study aimed to investigate the effect of ASH on MDD and potential therapeutic mechanisms.Materials and Methods:The chemical compound potential target network was predicted based on network pharmacology. Simultaneously, chronic unpredictable mild stress (CUMS) model mice were orally administrated ASH with three dosages (400, 200, and 100 mg/kg) for 6 weeks, and hepatic metabolomics based on gas chromatography–mass spectrometry (GC–MS) was carried out to identify differential metabolites and related metabolic pathways. Next, the integrated analysis of metabolomics and network pharmacology was applied to find the key target. Finally, molecular docking technology was employed to define the combination of the key target and the corresponding compounds.Results:A total of 13 metabolites and four related metabolic pathways were found in metabolomics analysis. From the combined analysis of network pharmacology and metabolomics, six targets (DAO, MAOA, MAOB, GAA, HK1, and PYGM) are the overlapping targets and two metabolic pathways (glycine, serine, and threonine metabolism and starch and sucrose metabolism) are the most related pathways. Finally, DAO, MAOA, MAOB, GAA, HK1, and PYGM were verified bounding well to their corresponding compounds including isofraxidin, eleutheroside B1, eleutheroside C, quercetin, kaempferol, and acacetin.Conclusion:Based on these results, it was implied that the potential mechanism of ASH on MDD was related to the regulation of metabolism of several excitatory amino acids and carbohydrates, as well as the expression of DAO, MAOA, MAOB, GAA, HK1, and PYGM.
Neospora caninum Infection Triggers S-phase Arrest and Alters Nuclear Characteristics in Primary Bovine Endothelial Host Cells
Authors: Velásquez Zahady D. , Rojas-Barón Lisbeth , Larrazabal Camilo , Salierno Marcelo , Gärtner Ulrich , Pervizaj-Oruqaj Learta , Herold Susanne , Hermosilla Carlos , Taubert Anja 
Published: August 2022

Neospora caninumrepresents a major cause of abortive disease in bovines and small ruminants worldwide. As a typical obligate intracellular apicomplexan parasite,N. caninumneeds to modulate its host cell for successful replication. In the current study, we focused on parasite-driven interference with host cell cycle progression. By performing DNA content-based cell cycle phase analyses inN. caninum-infected primary bovine umbilical vein endothelial cells (BUVEC), a parasite-driven S-phase arrest was detected at both 24 and 32 h p. i., being paralleled by fewer host cells experiencing the G0/G1 cell cycle phase. When analyzing S-subphases, proliferation cell nuclear antigen (per PCNA)-based experiments showed a reduced population of BUVEC in the late S-phase. Analyses on key molecules of cell cycle regulation documented a significant alteration of cyclin A2 and cyclin B1 abundance inN. caninum-infected host endothelial cells, thereby confirming irregularities in the S-phase and S-to-G2/M-phase transition. In line with cell cycle alterations, general nuclear parameters revealed smaller nuclear sizes and morphological abnormalities of BUVEC nuclei within theN. caninum-infected host cell layer. The latter observations were also confirmed by transmission electron microscopy (TEM) and by analyses of lamin B1 as a marker of nuclear lamina, which illustrated an inhomogeneous nuclear lamin B1 distribution, nuclear foldings, and invaginations, thereby reflecting nuclear misshaping. Interestingly, the latter finding applied to both non-infected and infected host cells within parasitized BUVEC layer. Additionally, actin detection indicated alterations in the perinuclear actin cap formation since typical nucleo-transversal filaments were consistently lacking inN. caninum-infected BUVEC, as also documented by significantly decreased actin-related intensities in the perinuclear region. These data indicate thatN. caninumindeed alters host cell cycle progression and severely affects the host cell nuclear phenotype in primary bovine endothelial host cells. In summary, these findings add novel data on the complexN. caninum-specific modulation of host cell and nucleus, thereby demonstrating clear differences in cell cycle progression modulation driven by other closely related apicomplexans likeToxoplasma gondiiandBesnotia besnoiti.
Phase transformation mechanism of MnCO3 as cathode materials for aqueous zinc-ion batteries
Authors: Zheng Junjie , Liu Pengcheng , Yao Jia , Gan Yi , Li Jingying , Wang Cong , Liu Xiang , Rao Yiheng , Ma Guokun , Lv Lin , Wang Hanbin , Tao Li , Zhang Jun , Wang Hao 
Published: August 2022

Aqueous rechargeable zinc-ion batteries (ZIBs) have been given more and more attention because of their high specific capacity, high safety, and low cost. The reasonable design of Mn-based cathode materials is an effective way to improve the performance of ZIBs. Herein, a square block MnCO3 electrode material is synthesized on the surface of carbon cloth by a one-step hydrothermal method. The phase transition of MnCO3 was accompanied by the continuous increase of specific capacity, and finally maintained good cycle stability in the charge–discharge process. The maximum specific capacity of MnCO3 electrode material can reach 83.62 mAh g−1 at 1 A g−1. The retention rate of the capacity can reach 85.24% after 1,500 cycles compared with the stable capacity (the capacity is 61.44 mAh g−1 under the 270th cycle). Ex situ characterization indicates that the initial MnCO3 gradually transformed into MnO2 accompanied by the embedding and stripping of H+ and Zn2+ in charge and discharge. When MnCO3 is no longer transformed into MnO2, the cycle tends to be stable. The phase transformation of MnCO3 could provide a new research idea for improving the performance of electrode materials for energy devices.
Sensitive electrochemical detection of p-nitrophenol by pre-activated glassy carbon electrode integrated with silica nanochannel array film
Authors: Su Ruobing , Tang Hongliang , Xi Fengna 
Published: August 2022

Convenient, rapid and sensitive detection of p-nitrophenol (p-NP), one of the priority environmental pollutants, in environmental samples is of great significance. Electrochemical sensor with simple fabrication process, high sensitivity and selectivity, good antifouling, and regeneration performance is highly desirable. Herein, an electrochemical sensing platform is demonstrated based on the integration of vertically-ordered mesoporous silica-nanochannel film (VMSF) on electrochemical pre-activated glassy carbon electrode (p-GCE), which is able to realize ultrasensitive detection of p-NP in environmental samples. Electrochemical pre-activation of GCE is achieved through a simple and green electrochemical polarization process including anodic oxidation at high voltage and the following cathodic reduction at low voltage. The p-GCE possesses enhanced active area and introduced active sites, and enables stable binding of VMSF. VMSF is easily grown on p-GCE through the electrochemically assisted self-assembly (EASA) method within 10 s. Owing to the hydrogen bonding between silanol groups and p-NP, VMSF nanochannels display strong enrichment effect for the detection of p-NP. The developed VMSF/p-GCE sensor can achieve sensitive detection of p-NP ranging from 10 nM to 1 μM and from 1 to 30 μM with a limit of detection (LOD) of 9.4 nM. Considering the antifouling ability of VMSF, detection of p-NP in pond water is achieved.
Unexpected kinetically controlled organoselenium-based isomaleimide: X-ray structure, hirshfeld surface analysis, 3D energy framework approach, and density functional theory calculation
Authors: Shaaban Saad , Ferjani Hela , Abd El-Lateef Hany M. , Khalaf Mai M. , Gouda Mohamed , Alaasar Mohamed , Yousef Tarek A. 
Published: August 2022

Reduction of 4,4′-diselanediyldianiline (1) followed by the reaction with bromo-4-(bromomethyl)benzene afforded the corresponding 4-((4-bromobenzyl)selanyl)aniline (2) in 85% yield. N-Maleanilic acid 3 was obtained in 94% yield via the reaction of selenoamine 2 with toxilic anhydride. Subsequent dehydration of N-maleanilic acid 3 using acetic anhydride furnished the unexpected isomaleimide 5-((4-((4-bromophenyl)selanyl)phenyl)imino)furan-2(5H)-one (4) instead of the maleimide 5. The molecular structure of compound 4 was confirmed by mass spectrometry, 1H- and 13C-NMR spectroscopy, and X-ray diffraction analysis. Their cytotoxicity was assessed against two oligodendrocytes, and their respective redox properties were evaluated using 2′,7′-dichlorodihydrofluorescein diacetate (H2-DCFDA) assay. Furthermore, their antiapoptotic potential was also evaluated by flow cytometry. The compound crystallizes in triclinic P-1 space group with unit cell parameters a = 5.7880 (4) Å, b = 9.8913 (6) Å, c = 14.5951 (9) Å, V = 1731.0 (3) Å3 and Z = 2. The crystal packing is stabilized by intermolecular hydrogen bonding, π···π, C-Br···π stacking interactions, and other non-covalent interactions. The mapping of different Hirshfeld surfaces and 2D-fingerprint were used to investigate intermolecular interactions. The interaction energies that stabilize the crystal packing were calculated and graphically represented as framework energy diagrams. We present a computational investigation of compound 4’s molecular structure at the Density Functional Theory level using the B3LYP method and the 6-31G ++ basis set in this paper. The optimized structure matches the experimental outcome. The global reactivity descriptors and molecular electrostatic potential (M.E.P.) map emphasize the molecule’s reactive locations, allowing reactivity prediction. The charge transfer properties of molecules can be estimated by examining Frontier molecular orbitals.
Shale Lithofacies and Its Effect on Reservoir Formation in Lower Permian Alkaline Lacustrine Fengcheng Formation, Junggar Basin, NW China
Authors: Tang Yong , He Wenjun , Zheng Menglin , Chang Qiusheng , Jin Zhijun , Li Jiao , Zhang Yuanyuan 
Published: August 2022

Lower Permian Fengcheng Formation is considered to be a high-quality alkaline lacustrine shale oil resource in the Junggar Basin, NW China. Based on core and thin section observation, X-ray diffraction, scanning electron microscope, low-pressure N2 adsorption, and high-pressure mercury intrusion porosimetry, different shale lithofacies, and pore structures were examined. According to the mineral composition, shales in well My 1 are divided into five types: dolomitic mudstone, calcareous mudstone, siliceous mudstone, tuffaceous mudstone, and argillaceous mudstone, each of which shows its pore structure distribution. Intragranular pores, inter-crystalline pores associated with clays and pyrites, dissolution pores, and microfractures were commonly observed. There are three segments of pore structures including &lt;50 nm, 50 nm-4 μm, and &gt;4 μm. Clay minerals mainly contribute to mesopores, especially in argillaceous mudstones. The dissolution of carbonate minerals and feldspars is significant for macropores predominantly in dolomitic mudstones and tuffaceous mudstones, respectively. Micron-scale microfractures associated with laminae dominate in dolomitic mudstones. Therefore, the dolomitic mudstones, especially with lamination, and tuffaceous mudstones are proposed to be favored shale lithofacies with great exploration potential in the Mahu Sag.
Dose dependency of aliquot sizes and age models from modern alluvial fan deposits of Helan Mountain, China
Authors: Liu Xiuying , Li Xiao , Zhao Qiuyue , Pan Baolin , Wang Junping , Wei Mingjian 
Published: August 2022

Alluvial fan deposits are identified as evidence of regional climatic variations and tectonic events; therefore, it is crucial to establish absolute time series by dating alluvial fan deposits. Limited exposure to light poses a challenge to accurately estimating the buried ages for alluvial deposits with optically stimulated luminescence (OSL). This challenge has been positively developed by controlling the number of grains on each disk to measure and choosing suitable statistical models for the equivalence dose (De) distribution to analyze. In this research, three modern alluvial samples and one modern loess-like sample were collected from the Dashuigou alluvial fan of Helan Mountain, China. The De distributions of these four samples were studied by the application of small aliquots (1-, 3-, and 5-mm aliquots) of quartz OSL with the average dose model, central age model, unlogged minimum age model (MAM), lowest 5%, internal/external consistency criterion minimum age model (IEU), and finite mixture model. It is concluded that an overestimation of De lower than 1 Gy can be obtained using quartz OSL dating of 1-mm aliquots (∼50 grains) with MAM and IEU for the alluvial sediments. The lowest 5% method may underestimate the De values of the 1-mm aliquots for young samples. This research makes the dose dependency of aliquot sizes and age models more definite and opens up the possibility of dating paleoalluvial deposits to establish a chronological framework to decipher the implications of paleoclimates and tectonics.