bluuebunny/crossref_metadata_2025_split huggingface dataset:
Transcriptome analysis of flathead grey mullet (Mugil cephalus) ovarian development induced by recombinant gonadotropin hormones
Authors: Ramos-Júdez Sandra , Danis Theodoros , Angelova Nelina , Tsakogiannis Alexandros , Giménez Ignacio , Tsigenopoulos Costas S. , Duncan Neil , Manousaki Tereza 
Published: November 2022

Background: Treatment with recombinant gonadotropin hormones (rGths), follicle-stimulating hormone (rFsh) and luteinizing hormone (rLh), was shown to induce and complete vitellogenesis to finally obtain viable eggs and larvae in the flathead grey mullet (Mugil cephalus), a teleost arrested at early stages of gametogenesis in intensive captivity conditions. This study aimed to investigate the transcriptomic changes that occur in the ovary of females during the rGths-induced vitellogenesis.Methods: Ovarian samples were collected through biopsies from the same five females at four stages of ovarian development. RNASeq libraries were constructed for all stages studied, sequenced on an Illumina HiSeq4000, and a de novo transcriptome was constructed. Differentially expressed genes (DEGs) were identified between stages and the functional properties of DEGs were characterized by comparison with the gene ontology and Kyoto Encyclopedia. An enrichment analysis of molecular pathways was performed.Results: The de novo transcriptome comprised 287,089 transcripts after filtering. As vitellogenesis progressed, more genes were significantly upregulated than downregulated. The rFsh application induced ovarian development from previtellogenesis to early-to-mid-vitellogenesis with associated pathways enriched from upregulated DEGs related to ovarian steroidogenesis and reproductive development, cholesterol metabolism, ovarian growth and differentiation, lipid accumulation, and cell-to-cell adhesion pathways. The application of rFsh and rLh at early-to-mid-vitellogenesis induced the growth of oocytes to late-vitellogenesis and, with it, the enrichment of pathways from upregulated DEGs related to the production of energy, such as the lysosomes activity. The application of rLh at late-vitellogenesis induced the completion of vitellogenesis with the enrichment of pathways linked with the switch from vitellogenesis to oocyte maturation.Conclusion: The DEGs and enriched molecular pathways described during the induced vitellogenesis of flathead grey mullet with rGths were typical of natural oogenesis reported for other fish species. Present results add new knowledge to the rGths action to further raise the possibility of using rGths in species that present similar reproductive disorders in aquaculture, the aquarium industry as well as the conservation of endangered species.
Well-being at work and Finnish dairy farmers─from job demands and loneliness towards burnout
Authors: Kallioniemi Marja K. , Kaseva Janne , Kymäläinen Hanna-Riitta , Hakanen Jari J. 
Published: November 2022

ObjectivesNovel information about the relationships between farmers’ job demands, lack of resource, burnout, and ill health is reported based on testing the so-called “health impairment process” of the Job Demands─Resources Model (JD-R) on a representative sample of Finnish dairy farmers. The aim was to find out whether two different job demand factors; workload, societal demands and lack of resource; loneliness, were related to the indicators of ill health via burnout.MethodsThe data is based on a postal survey of 400 Finnish dairy farms. Altogether 265 questionnaires were received from 188 farms and included in the analysis. The response rate was 47 per cent among sample farms. Structural equation modelling (SEM) was used to analyze the relationships between the variables. Explanatory factor analysis was used to group the job demand and lack of resource variables.ResultsWe identified two job demand factors, which we labelled workload and societal demands and one lacking job resource, loneliness. Our theoretical model was supported in that two of the factors, namely workload and loneliness, were related to ill health indirectly via burnout. In addition, workload was directly connected with ill health. Societal job demands were not significantly related to burnout, or to ill health.ConclusionOur results suggest that farmers could benefit from means to reduce workload, especially the physical load. This topic needs further research as the restructuring process has increased farm enterprise sizes. There is a need to develop tools and projects to alleviate loneliness among farmers. Lack of social support, high workload, ill health, and burnout among farmers may have serious direct and indirect negative consequences for the sustainability of farming.
Assessment of executive functions in school-aged children: A narrative review
Authors: Souissi Sofiane , Chamari Karim , Bellaj Tarek 
Published: November 2022

IntroductionIn the past three decades, there has been increasing interest in assessing children’s Executive Functions (EF). However, studies on the conceptualization and operationalization of this construct are incongruent and guidance for clinicians and researchers aiming to assess EF is insufficient due to measurement variability.AimsThe purpose of this article was to examine current theories and models of EF in children, identify their assessment instruments, issues, and challenges, and discuss their impact on children’s cognitive, behavioral, social and/or emotional development.MethodsThis narrative review reflected on English and French scholarly articles on EF assessment in children. References were identified through searches of PubMed, Medline, ScienceDirect, Google Scholar, and APA PsychNet throughout the last two decades up to June 2022.ResultsThere are commonalities despite divergence in the definition and operationalization of EF. Assessment of EF requires psychometric tests as well as rating scales that must be integrated and interpreted considering the child’s biological makeup, environmental background, and cultural specificities.ConclusionCurrent EF theories, assessment tools, issues, and challenges were discussed in addition to the impact of their components’ dysfunctions on children’s development. Further studies should be conducted to develop new measurement methods and technologies to improve the ecological and ethological validity of youth assessment, treatment, and interventions.
The application of tranexamic acid in joint arthroplasty: A 20-year bibliometric analysis
Authors: Zhang Jun , Zhao Runhan , Huang Yanran , Xiong Chuang , Liang Hao , Jiwa Habu , Luo Xiaoji 
Published: November 2022

BackgroundWith the arrival of the era of the aging population, the amount of joint arthroplasty surgery keeps rising, and the articles related to the application of tranexamic acid (TXA) in joint arthroplasty (we called the application of tranexamic acid in joint arthroplasty as TIA in this study) also show a blowout growth. Therefore, we conducted a bibliometric analysis of TIA-related publications to identify the main research trends and hot spots in this field in the last 20 years.MethodsIn this study, publications in the field of TIA from January 1, 2002 to December 31, 2021 were searched in the Web of Science Core Collection (WoSCC). A total of 1,013 publications were evaluated for specific characteristics with Microsoft Excel software, CiteSpace, VOSviewer, and Online Analysis Platform of Literature Metrology (http://bibliometric.com/).ResultsA total of 1,013 TIA-related articles were included in this study, and the number of articles in this field has increased yearly over the past 20 years. The USA and China dominated in the field of TIA. The Sichuan University published the most TIA-related articles among all the institutions. Of all the authors, Professor Pei was the most productive author with 64 articles. The lack of international cooperation was a significant problem in this field during the past 20 years. Furthermore, the results of the co-citation analysis and citation bursts analysis revealed that the safety and effectiveness of TIA and the optimal use strategy were the main trends and hotspots for the current and future.ConclusionThis bibliometric study reviewed the evolution trend of TIA research, and identified the countries, institutions, authors and journals that have made significant contributions to this field in the past 20 years, as well as the limitations and deficiencies in this field. In addition, this study revealed that the effectiveness and safety of TIA and the optimal use strategy was the current or future research trend and hotspot in this field.
Dynamic structures and emerging trends in the management of major trauma: A bibliometric analysis of publications between 2012 and 2021
Authors: Du Zhe , Wang Zhenzhou , Guo Fuzheng , Wang Tianbing 
Published: November 2022

ObjectiveMajor trauma is currently a global public health issue with a massive impact on health at both the individual and population levels. However, there are limited bibliometric analyses on the management of major trauma. Thus, in this study we aimed to identify global research trends, dynamic structures, and scientific frontiers in the management of major trauma between 2012 and 2021.MethodsWe searched the Web of Science Core Collection to access articles and reviews concerning the management of major traumas and conducted a bibliometric analysis using CiteSpace.ResultsOverall, 2,585 studies were screened and published by 403 institutions from 110 countries/regions. The most productive country and institution in this field of research were the USA and Monash University, respectively. Rolf Lefering was the most prolific researcher and Holcomb JB had the most co-citations. Injury published the highest number of articles, and the Journal of Trauma was the most co-cited journal. A dual-map overlay of the literature showed that the articles of most publications were confined to the areas of medicine/medical/clinical and neurology/sports/ophthalmology. Document clustering indicated severe traumatic brain injury, traumatic coagulopathy, and resuscitative endovascular balloon occlusion as the recent hot topics. The most recent burst keywords were “trauma management,” “neurocritical care,” “injury severity,” and “emergency medical services.”ConclusionThe dynamic structures and emerging trends in the management of major trauma were extensively analyzed using CiteSpace, a visualization software. Based on the analysis, the following research hotspots emerged: management of severe traumatic brain injury and massive hemorrhage, neurocritical care, injury severity, and emergency medical service. Our findings provide pertinent information for future research and contribute toward policy making in this field.
Relationship between physical activity levels of Portuguese physical therapists and mental health during a COVID-19 pandemic: Being active is the key
Authors: Almeida Laura Cristina , Grilo Ana , Carolino Elisabete , Tomás Maria Teresa 
Published: November 2022

IntroductionPhysical activity is essential for a healthy life and quality of life, representing a fundamental role in individuals' physical and mental health. Concomitantly, the physical therapist, through the promotion of physical activity and exercise, can improve mental health, an essential factor in the current pandemic, triggering anxiety, fear, and depression crisis.ObjectiveTo verify physical activity among Portuguese physical therapists and its association with mental health during pandemic times.MethodsAn online questionnaire was applied through social media to all Portuguese physical therapists between October 21, 2021, and January 14, 2022. It contained general characterization questions of the sample, the IPAQ-SF questionnaire to assess physical activity levels, the Goldberg General Health Questionnaire (GHQ-28), which assesses the levels of mental health and the WHO Well-Being Index (WHO-5) to assess the subjective wellbeing.ResultsThe sample totaled 286 respondents (82% female), with a mean age of 33. Of the total answers, 82% practiced physical activity, 45% had moderate levels of physical activity, and 19% vigorous. Physical therapists in these categories had lower values in the GHQ-28 and higher in the WHO-5. Those with better mental health also showed better subjective wellbeing (r = −0.571, p = 0.000).ConclusionThe data obtained showed that physical therapists mostly have moderate and vigorous levels of physical activity and that physical activity positively influences individuals' mental health and wellbeing, which proved to be a key factor due to the pandemic situation.
Medical disaster response: A critical analysis of the 2010 Haiti earthquake
Authors: Arnaouti Matthew Keith Charalambos , Cahill Gabrielle , Baird Michael David , Mangurat Laëlle , Harris Rachel , Edme Louidort Pierre Philippe , Joseph Michelle Nyah , Worlton Tamara , Augustin Sylvio ,   The Haiti Disaster Response – Junior Research Collaborative (HDR-JRC)
Published: November 2022

IntroductionOn January 12, 2010, a 7.0 magnitude earthquake struck the Republic of Haiti. The human cost was enormous—an estimated 316,000 people were killed, and a further 300,000 were injured. The scope of the disaster was matched by the scope of the response, which remains the largest multinational humanitarian response to date. An extensive scoping review of the relevant literature was undertaken, to identify studies that discussed the civilian and military disaster relief efforts. The aim was to highlight the key-lessons learned, that can be applied to future disaster response practise.MethodsPreferred Reporting Items for Systematic reviews and Meta-Analyses extension for Scoping Reviews guidance was followed. Seven scientific databases were searched, using consistent search terms—followed by an analysis of the existent Haitian literature. This process was supplemented by reviewing available grey literature. A total of 2,671 articles were reviewed, 106 of which were included in the study. In-depth analysis was structured, by aligning data to 12 key-domains, whilst also considering cross-sector interaction (Civilian-Civilian, Military-Military, and Civilian-Military). Dominant themes and lessons learned were identified and recorded in an online spreadsheet by an international research team. This study focuses on explicitly analysing the medical aspects of the humanitarian response.ResultsAn unpreceded collaborative effort between non-governmental organisations, international militaries, and local stakeholders, led to a substantial number of disaster victims receiving life and limb-saving care. However, the response was not faultless. Relief efforts were complicated by large influxes of inexperienced actors, inadequate preliminary needs assessments, a lack of pre-existing policy regarding conduct and inter-agency collaboration, and limited consideration of post-disaster redevelopment during initial planning. Furthermore, one critical theme that bridged all aspects of the disaster response, was the failure of the international community to ensure Haitian involvement.ConclusionsNo modern disaster has yet been as devastating as the 2010 Haiti earthquake. Given the ongoing climate crisis, as well as the risks posed by armed conflict—this will not remain the case indefinitely. This systematic analysis of the combined civilian and military disaster response, offers vital evidence for informing future medical relief efforts—and provides considerable opportunity to advance knowledge pertaining to disaster response.
Intestinal neuronal dysplasia presenting as psoas abscess: A case report
Authors: Ren Bing Bing , Zhang Bo , Chen Shu Xian , Han Hong Qiu , Sun Da Qing 
Published: November 2022

BackgroundIntestinal neuronal dysplasia (IND) is a rare condition mainly affecting the children. Constipation and abdominal distension have been reported as common manifestations. In addition, the reports about adult cases are scarce.Case reportA 31-year-old man presented with pain in his left hip and intermittent fever for 1 month. The whole abdomen CT and pelvic contrast-enhanced MRI revealed a left psoas abscess (PA). The patient has been given anti-infective treatment and underwent CT-guided drainage of left PA with a temporary drain. But the patient's condition did not improve significantly. Then, the colonoscopy revealed that it may be the PA secondary to inflammatory bowel disease. But the pathology was not in line with inflammatory bowel disease. We finally performed an ileostomy surgery and took the whole layer of intestinal wall for biopsy. The pathological result revealed that a large number of proliferative ganglion cells and circuitous hyperplastic nerve fibers were found in the submucosa and muscular layer of the intestinal wall. Given pathological results and clinical manifestations, the patient was diagnosed with IND-B.ConclusionIn this case, we first report an extremely rare case of adult IND manifesting as PA. So, this unusual case provides a new supplement to adult cases of IND.
Natriuretic peptide testing and heart failure diagnosis in primary care: diagnostic accuracy study
Authors: Taylor Clare J , Ordóñez-Mena José M , Lay-Flurrie Sarah L , Goyder Clare R , Taylor Kathryn S , Jones Nicholas R , Roalfe Andrea K , Hobbs FD Richard 
Published: November 2022

BackgroundNatriuretic peptide (NP) testing is recommended for patients presenting to primary care with symptoms of chronic heart failure (HF) to prioritise referral for diagnosis.AimTo report NP test performance at European Society of Cardiology (ESC) and National Institute for Health and Care Excellence (NICE) guideline referral thresholds.Design and settingDiagnostic accuracy study using linked primary and secondary care data (2004 to 2018).MethodThe sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of NP testing for HF diagnosis was assessed.ResultsIn total, 229 580 patients had an NP test and 21 102 (9.2%) were diagnosed with HF within 6 months. The ESC NT-proBNP threshold ≥125 pg/mL had a sensitivity of 94.6% (95% confidence interval [CI] = 94.2 to 95.0) and specificity of 50.0% (95% CI = 49.7 to 50.3), compared with sensitivity of 81.7% (95% CI = 81.0 to 82.3) and specificity of 80.3% (95% CI = 80.0 to 80.5) for the NICE NT-proBNP ≥400 pg/mL threshold. PPVs for an NT-proBNP test were 16.4% (95% CI = 16.1 to 16.6) and 30.0% (95% CI = 29.6 to 30.5) for ESC and NICE thresholds, respectively. For both guidelines, nearly all patients with an NT-proBNP level below the threshold did not have HF (NPV: ESC 98.9%, 95% CI = 98.8 to 99.0 and NICE 97.7%, 95% CI = 97.6 to 97.8).ConclusionAt the higher NICE chronic HF guideline NP thresholds, one in five cases are initially missed in primary care but the lower ESC thresholds require more diagnostic assessments. NP is a reliable ‘rule-out’ test at both cut-points. The optimal NP threshold will depend on the priorities and capacity of the healthcare system.
Underlying cancer risk among patients with fatigue and other vague symptoms: a population-based cohort study in primary care
Authors: White Becky , Renzi Cristina , Barclay Matthew , Lyratzopoulos Georgios 
Published: November 2022

BackgroundPresenting to primary care with fatigue is associated with slightly increased cancer risk, although it is unknown how this varies in the presence of other ‘vague’ symptoms.AimTo quantify cancer risk in patients with fatigue who present with other ‘vague’ symptoms in the absence of ‘alarm’ symptoms for cancer.Design and settingCohort study of patients presenting in UK primary care with new-onset fatigue during 2007–2015, using Clinical Practice Research Datalink data linked to national cancer registration data.MethodPatients presenting with fatigue without co-occurring alarm symptoms or anaemia were identified, who were further characterised as having co-occurrence of 19 other ‘vague’ potential cancer symptoms. Sex- and age-specific 9-month cancer risk for each fatigue–vague symptom cohort were calculated.ResultsOf 285 382 patients presenting with new-onset fatigue, 84% (n= 239 846) did not have co-occurring alarm symptoms or anaemia. Of these, 38% (n= 90 828) presented with ≥1 of 19 vague symptoms for cancer. Cancer risk exceeded 3% in older males with fatigue combined with any of the vague symptoms studied. The age at which risk exceeded 3% was 59 years for fatigue–weight loss, 65 years for fatigue–abdominal pain, 67 years for fatigue–constipation, and 67 years for fatigue–other upper gastrointestinal symptoms. For females, risk exceeded 3% only in older patients with fatigue–weight loss (from 65 years), fatigue–abdominal pain (from 79 years), or fatigue–abdominal bloating (from 80 years).ConclusionIn the absence of alarm symptoms or anaemia, fatigue combined with specific vague presenting symptoms, alongside patient age and sex, can guide clinical decisions about referral for suspected cancer.
Uso de <em>Musa</em> spp. no tratamento antiparasitário em animais: Revisão de literatura
Authors: da Silva Lisete de Oliveira , Furtado Rafaela Luca , Fiscuk Eduarda Barruffe , Ferreira Vitória Santos , Camargo Eduarda , da Silva Bruna Zafalon , França Raqueli Teresinha , Gorczak Rochelle 
Published: November 2022

A fitoterapia caracteriza-se na utilização de substratos naturais, em diferentes preparações, para melhora de estados patológicos, seja na atenuação ou na cura dos mesmos, bem como na sua profilaxia. A fitoterapia é uma alternativa ao uso de anti-helmínticos, embora financeiramente acessível para o caso de algumas plantas, normalmente está associada ao conhecimento empírico, portanto carece de maiores estudos científicos para determinar a eficácia das diversas espécies de plantas com potencial antiparasitário. Dentre elas está a bananeira (Musa spp.) que vem sendo citada como um fitoterápico com atividade anti-helmíntica principalmente por possuir em sua composição taninos que exercem ação direta sobre helmintos, interferindo no ciclo natural destes parasitas. Partindo desse princípio, o objetivo da presente revisão é descrever os estudos científicos que utilizaram Musa spp. como alternativa para o tratamento antiparasitário em Medicina Veterinária. Os estudos descritos na presente revisão apresentam resultados, bem como metodologias distintas entre si, embora as análises coproparasitológicas tenham sido semelhantes entre todos os estudos revisados. Todavia as formas e os intervalos de administração, quantidade/dose e frequência diferenciam-se entre estudos, e poucos realizaram testes de toxicidade da Musa spp. Portanto a utilização da Musa spp. como antiparasitário ainda carece de estudos na medicina veterinária, bem como estudos sobre a sua toxicidade, dosagem e frequência de administração.