bluuebunny/crossref_metadata_2025_split huggingface dataset:
Acute and Chronic Physical Activity Increases Creative Ideation Performance: A Systematic Review and Multilevel Meta-analysis
Authors: Rominger Christian , Schneider Martha , Fink Andreas , Tran Ulrich S. , Perchtold-Stefan Corinna M. , Schwerdtfeger Andreas R. 
Published: May 2022

Abstract
Background
Physical activity is a health-relevant lifestyle factor associated with various benefits on physical and mental health. Several meta-analyses indicated effects of acute and chronic physical activities on elementary cognitive functions such as executive control processes, memory, and attention. Meta-analytic evidence on the effects of physical activity on creative idea generation, which involves a conglomerate of these elementary cognitive functions, is largely missing.

Objective
A twofold approach was used to evaluate (1) if there is an association between habitual physical activity and creative ideation and (2) if physical activity interventions (acute and chronic) enhance creative ideation performance.

Methods
Multilevel meta-analytic methods were applied to (1) evaluate the cross-sectional association between creative ideation performance and measures of habitual physical activity and (2) the effect of physical activity on creative ideation performance. Indicators of creative ideation (fluency, flexibility, originality, elaboration, or composite score), creativity domain (verbal, figural), population (adults, children), gender, study quality, and publication year served as moderator variables for both meta-analyses. Analyses of intervention studies additionally examined the moderator variables study design (between, within), time of measurement (during, after), and implementation of intervention (acute, chronic).

Results
The applied meta-analytic multilevel analysis indicated a medium effect for cross-sectional studies (r = 0.22, SE = 0.06, p = 0.002, 95% CI [0.10–0.34]) based on 17 effects sizes from seven studies. The pooled effects of 28 intervention studies, providing 115 effect sizes, indicated a medium effect size of Hedges’ g = 0.47 (SE = 0.09, p < 0.001, 95% CI [0.30–0.65]). Furthermore, a stronger effect was observed for chronic interventions of several days or weeks in comparison with acute interventions of one single bout.

Conclusion
This study adds important new meta-analytic evidence on the beneficial role of physical activity beyond mental and physical health outcomes: Physical activity has a positive impact on creative ideation, which expands the literature on the role of physical activity in more elementary cognitive functions such as executive control, memory, and attention. Moderator analyses suggested that chronic interventions showed stronger effects than single bouts of physical activity. Rigorously conducted randomized controlled intervention studies and more cross-sectional studies are needed to broaden the evidence in this nascent field of research.
Reading digital- versus print-easy texts: a study with university students who prefer digital sources
Authors: Bresó-Grancha Noemí , Jorques-Infante María José , Moret-Tatay Carmen 
Published: May 2022

AbstractThe transition from on-paper to on-screen reading seems to make it necessary to raise some considerations, as a greater attentional effort has been claimed for print texts than digital ones. Not surprisingly, most university students prefer this digital medium. This research aims to examine reading times by contextualizing this phenomenon into two processes: namely, word recognition and reading comprehension task on paper and on screen. Thus, two different tasks—counterbalanced into digital and print mediums—were carried out per each participant with a preference for a digital medium: a reading comprehension task (RCT) and a lexical decision task (LDT) after reading a specific story. Participants were slower reading print texts and no statistically significant differences were found in RCT accuracy. This result suggests that the task required more cognitive resources under the print medium for those with a worse comprehension performance in reading, and a more conservative pattern in digital RCT for those with a better performance.
Molecular characterization and identification of bhendi yellow vein mosaic virus with satellite DNAs infecting okra plants of district Mardan, Pakistan
Authors: Shuja Malik Nawaz , Riaz Hasan , Ali Muhammad , Qasim Muhammad , Anees Muhammad , Winter Stephan , Hassan Sabry , Hassan Mohamed M. , Elsharkawy Mohsen Mohamed 
Published: May 2022

Abstract
Background
Bhendi or okra (Abelmoschus esculentus) is an important crop widely cultivated in the Indian subcontinent. The production of okra in tropical regions is constrained by several abiotic and biotic factors. Among biotic stresses, yellow vein mosaic disease (YVMD), transmitted by the whitefly (Bemisia tabaci Genn.), causes significant production losses.

Results
Leaves showing symptoms of YVMD were collected from okra plants in the district of Mardan, Pakistan, from which the total nucleic acid was extracted. It was found that the viral genome was 2739 bp in the length and had seven conserved open reading frames, comparable to those of monopartite begomovirus species from the Old World. Nucleotide sequence comparison revealed that the genome has 97.7% identity with bhendi yellow vein mosaic virus (BYVMV). Additionally, alpha- and betasatellite DNA components were amplified and sequenced. The alpha- and betasatellite DNA sequences were 1367 and 1346 nt in length, respectively. Sequence analysis revealed that the alpha- and betasatellite sequences shared 97.9 and 98.7% similarity with cotton leaf curl Multan alphasatellite DNA (CLCuMuA) and croton yellow vein mosaic betasatellite DNA (CroYVMB), respectively.

Conclusions
Based on the prevailing classification system, the isolate was identified as a variant of BYVMV, CLCuMuA, and CroYVB. Alphasatellite presence in the begomovirus betasatellite complex detected in the present study indicated a recent mobilization into the viral complex infecting okra in this region. The study findings may facilitate the design of new management strategies to protect this valuable crop against begomovirus infection.
Association of Hypoxia-Inducible Factor 1α Gene Polymorphisms With Breast Cancer Susceptibility: A Meta-Analysis
Authors: Islam Md. Shihabul , Jesmin  
Published: May 2022

PURPOSE Overexpression of the hypoxia-inducible factor 1α (HIF1A) gene is significantly associated with different types of cancers, including breast cancer. In this study, the effects of single-nucleotide polymorphisms rs11549465, rs11549467, and rs2057482 of the HIF1A gene and their association with breast cancer were systematically investigated through meta-analysis. MATERIALS AND METHODS After a systematic review, nine case-control studies of the HIF1A rs11549465 C/T polymorphism, six case-control studies of the HIF1A rs11549467 G/A polymorphism, and one case-control study of the HIF1A rs2057482 C/T polymorphism were included in this meta-analysis. The summary pooled odds ratios with 95% CIs were evaluated to detect the relationship between HIF1A polymorphisms and breast cancer susceptibility. RESULTS Subgroup-stratified analyses showed that the T and TT genotypes of the HIF1A rs11549465 C/T polymorphism were significantly associated with increased breast cancer risk in the Asian population under three genetic models (allele, homozygous, and recessive). HIF1A rs11549467 G/A analyses indicated that the A and AA genotypes were significantly associated with increased breast cancer risk in the Asian population under allele and dominant models. However, no association with breast cancer was observed in the White population for the HIF1A rs11549465 C/T and rs11549467 G/A polymorphisms. In addition, the HIF1A rs2057482 C/T polymorphism showed no association with breast cancer under any genetic models or by ethnicity-stratified analyses. CONCLUSION The results of this meta-analysis suggested that the HIF1A rs11549465 C/T and rs1154946 G/A polymorphisms were significantly associated with increased breast cancer risk in the Asian population, but no associations were found in the White population. Thus, HIF1A could be an important biomarker for population-based breast cancer screening.
Genomic Features of Lung-Recurrent Hormone-Sensitive Prostate Cancer
Authors: Fonseca Nicolette M. , Van der Eecken Kim , Herberts Cameron , Verbeke Sofie , Ng Sarah W.S. , Lumen Nicolaas , Ritch Elie , Murtha Andrew J. , Bernales Cecily Q. , Schönlau Elena , Moris Lisa , Van Dorpe Jo , Annala Matti , Wyatt Alexander W. , Ost Piet 
Published: May 2022

PURPOSE Pulmonary involvement is rare in metastatic hormone-sensitive prostate cancer (mHSPC) that recurs after treatment for localized disease. Guidelines recommend intensive systemic therapy, similar to patients with liver metastases, but some lung-recurrent mHSPC may have good outcomes. Genomic features of lung metastases may clarify disease aggression, but are poorly understood since lung biopsy is rarely performed. We present a comparative assessment of genomic drivers and heterogeneity in metachronous prostate tumors and lung metastases. METHODS We leveraged a prospective functional imaging study of 208 biochemically recurrent prostate cancers to identify 10 patients with lung-recurrent mHSPC. Histologic diagnosis was attained via thoracic surgery or fine-needle lung biopsy. We retrieved clinical data and performed multiregion sampling of primary tumors and metastases. Targeted and/or whole-exome sequencing was applied to 46 primary and 32 metastatic foci. RESULTS Unusually for mHSPC, all patients remained alive despite a median follow-up of 11.5 years. Several patients experienced long-term freedom from systemic treatment. The genomic landscape of lung-recurrent mHSPC was typical of curable prostate cancer with frequent PTEN, SPOP, and chromosome 8p alterations, and there were no deleterious TP53 and DNA damage repair gene mutations that characterize aggressive prostate cancer. Despite a long median time to recurrence (76.8 months), copy number alterations and clonal mutations were highly conserved between metastatic and primary foci, consistent with intrapatient homogeneity and limited genomic evolution. CONCLUSION In this retrospective hypothesis-generating study, we observed indolent genomic etiology in selected lung-recurrent mHSPC, cautioning against grouping these patients together with liver or bone-predominant mHSPC. Although our data do not generalize to all patients with lung metastases, the results encourage prospective efforts to stratify lung-recurrent mHSPC by genomic features.
Short-Term Fasting Attenuates Overall Steroid Hormone Biosynthesis in Healthy Young Women
Authors: Magyar Benjamin P , Santi Maristella , Sommer Grit , Nuoffer Jean-Marc , Leichtle Alexander , Grössl Michael , Fluck Christa E 
Published: May 2022

Abstract

Context
Fasting is stressful for the human body. It is managed by metabolic adaptations maintaining energy homeostasis and involves steroid hormone biosynthesis, but the exact interplay between energy and steroid metabolism remains elusive. Women with polycystic ovary syndrome (PCOS) suffer from disturbed metabolism and androgen excess, while in women with anorexia nervosa, cortisol and androgen production are decreased. By contrast, starvation of steroidogenic cells shifts adrenal steroid biosynthesis toward enhanced androgen production.

Aim
This study investigated the effect of fasting on steroid production in healthy women.

Methods
Twenty healthy young women fasted for 48 hours; steroid profiles from plasma and urine samples were assessed at baseline, after 24 hours, and 48 hours by liquid and gas chromatography–mass spectrometry.

Results
Fasting did not change overall steroidogenesis, although it increased progestogen production and lowered relative mineralocorticoid, glucocorticoid, and androgen production. The largest decrease in urine metabolites was seen for β-cortol, dehydroepiandrosterone, and androstenediol; higher levels were found for pregnanediol in urine and progesterone and aldosterone in serum. Activity of 17α-hydroxylase/17,20-lyase (CYP17A1), essential for androgen biosynthesis, was decreased after fasting in healthy women as were 21-hydroxylase (CYP21A2) and 5α-reductase activities. By contrast, hydroxysteroid 11-beta dehydrogenase 1 (HSD11B1) activity for cortisol inactivation seemed to increase with fasting.

Conclusion
Significant changes in steroid metabolism occurred after 48 hours of fasting in healthy women. In contrast to metabolic changes seen at baseline in PCOS women compared to healthy women, and after starving of steroidogenic cells, no androgen excess was observed after short-term fasting in healthy young women.
A View of a Landscapeand Other Church Problems
Authors: Raengo Alessandra 
Published: May 2022

AbstractThinking with Fred Moten's approach to aesthetics in the trilogy consent not to be a single being and Kevin Beasley's A view of a landscape: A cotton gin motor, 2012–18, this introduction reflects on the way the philosophical project of aesthetics is entangled in the relationships between the legal and the paralegal, law and lawlessness, sensibility and sensoriality, form and informality, nonsense and common sense, exclusion and invagination, objecthood and thingness, motion and stillness, as well as the previousness, prematurity, and postexpectancy of black generativity. Inspired by the issue's contributions’ option for incompleteness and canted temporality and by Moten's description of a “church problem” as the problem of the togetherness of things, it then approaches the issue's content thinking, practicing, or witnessing “undercommonsense” in the making, whereby the aesthetic can be understood not only as a processing site but also as a space of congregation.
Doing It, Fluid
Authors: Prettyman Michele 
Published: May 2022

Abstract
In this interview essay Michele Prettyman talks with filmmaker, moving image artist, curator, and producer Elissa Blount Moorhead about her work, the power of collaboration, and her innovative praxis. Taking some inspiration from black musical traditions, which are central to Blount Moorhead's roots, Prettyman borrows the essay's title phrasing, “Doing It, Fluid,” from a song by the group the Blackbyrds. The song's aggregation of an array of sonic components embodies the capacities of black expressive life to animate multiple creative impulses at once, providing a compelling analogy to Blount Moorhead's “fluid” practices of black making, gathering, and collaboration. The introductory essay outlines ways in which fluidity is useful both as an analytic and as an approach to studying Blount Moorhead's work, which often reveals unseen nuances in Black life by visually reconstituting images, artifacts, memories, and speculative histories. Prettyman also explores Blount Moorhead's role in shaping an art and moving image collective of Black media makers in Baltimore, coining the phrase “the Baltimore Arts and Image Renaissance (BAIR),” and citing Baltimore as an important base for Blount Moorhead, Bradford Young, and filmmaker Radha Blank, among others, and as a hub for TNEG, a film production studio helmed by Blount Moorhead, Malik Hassan Sayeed, and Arthur Jafa. Together the essay and interview reveal the impact of Blount Moorhead's praxis and the ways in which contemporary Black filmmakers remain connected to histories of Black creative collectives while also reimagining black aesthetic and technological possibilities.
Accessible analysis of longitudinal data with linear mixed effects models
Authors: Murphy Jessica I. , Weaver Nicholas E. , Hendricks Audrey E. 
Published: May 2022

ABSTRACT
Longitudinal studies are commonly used to examine possible causal factors associated with human health and disease. However, the statistical models, such as two-way ANOVA, often applied in these studies do not appropriately model the experimental design, resulting in biased and imprecise results. Here, we describe the linear mixed effects (LME) model and how to use it for longitudinal studies. We re-analyze a dataset published by Blanton et al. in 2016 that modeled growth trajectories in mice after microbiome implantation from nourished or malnourished children. We compare the fit and stability of different parameterizations of ANOVA and LME models; most models found that the nourished versus malnourished growth trajectories differed significantly. We show through simulation that the results from the two-way ANOVA and LME models are not always consistent. Incorrectly modeling correlated data can result in increased rates of false positives or false negatives, supporting the need to model correlated data correctly. We provide an interactive Shiny App to enable accessible and appropriate analysis of longitudinal data using LME models.
Clay Column Chromatography for Optical Resolution: A Series of Derivatized Amino Acids
Authors: Yamagishi Akihiko , Yamamoto Shohei , Takimoto Kazuyoshi , Tamura Kenji , Kamon Masumi , Sato Fumi , Sato Hisako 
Published: May 2022

Abstract
Chromatographic resolution of a series of derivatized amino acids was attempted on a column packed with an ion-exchange adduct of Δ-[Ru(phen)3]2+ (phen = 1,10-phenanthroline) and synthetic hectorite. An amino acid was modified to N-3, 5-dinitrobenzoyl amino acid methyl ester (denoted by DNB-aa-me). For aa = Ala, Phe, Leu, Ile, Ser, Val, Thr, Tyr, Asp and Glu, racemic DNB-aa-me was resolved nearly to baseline separation on being eluted with methanol. For aa = Trp and His, racemic DNB-aa-me was resolved partially. No resolution was achieved for Pro and Lys. The mechanism of chiral discrimination was investigated by means of solid-state vibrational circular dichroism spectroscopy.
Effects of Exercise Training Intensity and Duration on Skeletal Muscle Capillarization in Healthy Subjects: A Meta-analysis
Authors: LIU YUJIA , CHRISTENSEN PETER M. , HELLSTEN YLVA , GLIEMANN LASSE 
Published: May 2022

ABSTRACT

Purpose
This study aimed to investigate the effect of intensity and duration of continuous and interval exercise training on capillarization in skeletal muscle of healthy adults.

Methods
PubMed and Web of Science were searched from inception to June 2021. Eligibility criteria for studies were endurance exercise training >2 wk in healthy adults, and the capillary to fiber ratio (C:F) and/or capillary density (CD) reported. Meta-analyses were performed, and subsequent subgroup analyses were conducted by the characteristics of participants and training scheme.

Results
Fifty-seven trials from 38 studies were included (10%/90%, athletic/sedentary). C:F was measured in 391 subjects from 47 trials, whereas CD was measured in 428 subjects from 50 trials. Exercise training increased C:F (mean difference, 0.33 (95% confidence interval, 0.30–0.37)) with low heterogeneity (I
2 = 45.08%) and CD (mean difference, 49.8 (36.9–62.6) capillaries per millimeter squared) with moderate heterogeneity (I
2 = 68.82%). Compared with low-intensity training (<50% of maximal oxygen consumption (V̇O2max)), 21% higher relative change in C:F was observed after continuous moderate-intensity training (50%–80% of V̇O2max) and 54% higher change after interval training with high intensity (80%–100% of V̇O2max) in sedentary subjects. The magnitude of capillary growth was not dependent on training intervention duration. In already trained subjects, no additional increase in capillarization was observed with various types of training.

Conclusions
In sedentary subjects, continuous moderate-intensity training and interval training with high intensity lead to increases in capillarization, whereas low-intensity training has less effect. Within the time frame studied, no effect on capillarization was established regarding training duration in sedentary subjects. The meta-analysis highlights the need for further studies in athlete groups to discern if increased capillarization can be obtained, and if so, which combination is optimal (time vs intensity).
Sociodemographic characteristics of community eye screening participants: protocol for cross-sectional equity analyses in Botswana, Kenya, and Nepal
Authors: Allen Luke N , Nkomazana Oathokwa , Kumar Mishra Sailesh , Ratshaa Bakgaki , Ho-Foster Ari , Rono Hillary , Roshan Abhiskek , Macleod David , Kim Min , Patricia Marques Ana , Bolster Nigel M , Burton Matthew J , Gichangi Michael , Karanja Sarah , Bastawrous Andrew 
Published: May 2022

Background: Attendance rates for eye clinics are low across low- and middle-income countries (LMICs) and exhibit marked sociodemographic (SD) inequalities. We aimed to quantify the association between a range of SD domains and attendance rates from vision screening in programmes launching in Botswana, Kenya and Nepal. Methods: We will develop a set of sociodemographic questions and introduce them into routine community-based eye screening programmes in Kenya, Botswana and Nepal, targeting children aged 5-18 years and adults. Our study design is a rolling survey, embedded within the Peek screening programme. The sociodemographic questions will be asked of 10% of all those presenting to be screened, and 100% of those identified with an eye problem. We will also collect data on whether people referred to ophthalmic clinic for treatment or further assessment attended, and we will use logistic regression to report odds ratios for this outcome attendance) for each socioeconomic domain in each country. We hypothesise that attendance rates will be lowest among marginalised sociodemographic groups such as older, less educated, less wealthy women. To identify the most appropriate sociodemographic items we will perform a literature review, and then hold workshops with researchers, academics, programme implementers, and programme designers in each country to tailor the domains and response options to the national context. We will report outcome data at 6 and 12 months, identifying the groups facing the highest barriers to access. Discussion: This low-risk, embedded, pragmatic, observational data collection will enable eye screening programme managers to accurately identify which sociodemographic groups are facing the highest systematic barriers to accessing care at any point in time. This information will be used to inform the development of service improvements to improve equity.
Comparative evaluation of different types of bariatric surgery
Authors: Prodan A. , Dzhyvak V. 
Published: May 2022

Introduction. The use of bariatric surgery as a treatment for obesity has increased dramatically over the past few years. Because the results in obese patients with type 2 diabetes were so impressive, the International Diabetes Federation recommended considering bariatric surgery as an acceptable treatment option in patients with a BMI of 30-35 kg / m2 when diabetes cannot be adequately controlled with traditional therapies.
The aim of the study is to compare the results of bariatric surgery in patients with metabolic syndrome according to the dynamics of body mass index and major orexigenic and anorexigenic hormones.
Material and Methods. The results of surgical treatment of 19 patients with morbid obesity (5 men and 14 women) aged 44 ± 3.26 years with a body mass index ˃40 kg / m2 were evaluated. The control group consisted of 12 patients with normal body mass index and no manifestations of metabolic syndrome.
Results. Our study also demonstrated the positive effect of LGAE on hormonal parameters with a decrease in ghrelin and leptin. This helped reduce BMI by 10.12% after 6 months. At the same time there is an increase in adiponectin and resistin.
Conclusions. LGAE in patients with ghrelin-associated obesity is possible as an alternative intervention, given its good tolerability. Or, as the first preparatory stage of comprehensive surgical treatment in obese patients who are not good candidates for standard bariatric surgery.