bluuebunny/crossref_metadata_2025_split huggingface dataset:
Flat plate and evacuated tube collectors solar water heater system – A comparative study
Authors: Hujailan Faleh F.F. , Maleque Md Abdul , Mustafizur Md 
Published: July 2022

Abstract
Renewable energy for the sustainable energy application in the buildings are increasing day-by-day. The aim of this study is to compare flat plate and evacuated tube collectors system in solar water heating of urban building. The two types of solar water heater systems were designed and evaluated based on the requirements of the urban building dwellers. The F-chart method along with commercial software was used to study the performance efficiency of the solar water heater system at an operating temperature of 65 °C. An economic analysis was also carried out using the same tool for both types of collectors with the desired designed parameters. The performance efficiency results of flat plate and evacuated tube collector are 77 % and 67.3 %, respectively. The economic analysis showed that flat plate collector is cost-effective for the solar water heater system due to its steadiness and lower maintenance costs.
Tunnel-magnetoresistive-based Pulsed Eddy Current Probe for Inspection of Corrosion under Insulation
Authors: Mohamed Mohamoud Hussein , Sophian Ali , Sulaiman Nadzril , Adesta Erry Yulian Triblas 
Published: July 2022

Abstract
The problem of corrosion in the industrial oil and gas pipes has been one of the major contributors in catastrophic structural failures. Among the various types of corrosion, corrosion under insulation (CUI) has been known to cause serious problems. Pulsed eddy current (PEC) non-destructive testing has shown its effectiveness in detecting hidden CUI. Most PEC systems have been developed by using an inductive coil as their sensing device, while some use a magnetic sensor which potentially offers better resolution. A new probe design based on a solid-state Tunnel magnetoresistance (TMR) is presented. TMR sensors offer higher sensitivities compared to other commercially available sensors. The performance of the probe is evaluated by using ferromagnetic mild steel plates that have thicknesses in the range of 8mm to 12mm at different stand-offs with a thin aluminium sheet under the probe. The different thicknesses represent different corrosion levels, while the stand-offs and thin aluminium sheet are to mimic the insulation of different thicknesses and the cladding in the real pipeline structure. The results show an overall mean absolute error (MAE) of 0.19 mm, which is better than our existing Hall-device-based PEC probe.
Temporal Branch Ablation for the Treatment of Facial Rhytids: A New Surgical Technique
Authors: Viterbo Fausto , Fonseca Eduardo , Magnani Lucas V , Neto Balduino F M 
Published: July 2022

Abstract

Background
Frontal wrinkles are a cause of distress for many people as they age. Traditionally, these have been treated with botulinum toxin injections. However, this procedure is not free from complications and has a temporary result. This report describes a procedure involving temporal branch of facial nerve ablation, a novel and simple technique for the treatment and prevention of rhytids.

Objectives
The objective of this study was to introduce this new technique of ablation for the treatment of frontal wrinkles after analyzing 3 options of approach based on the number of ablation lines.

Methods
Fifty-one patients with a mean age of 49 years underwent nerve ablation. The temporal nerve branches were located through electrostimulation. Through a skin puncture in the temporal region, an Abbocath, with part of the plastic coating removed at its base, was introduced. The nerve branches were cauterized in oblique lines with a monopolar electric scalpel. Patients were divided into 3 groups, depending on the number of ablation lines.

Results
The median follow-up period was 20 months (range, 1-50 months). Only 3 (5.7%) patients developed unilateral relapse of muscle activity in the frontal region. Group 6 was statistically superior to Group 1. There was no statistically significant difference between Group 4 and the other 2 groups. More than 70% of patients were satisfied or very satisfied with the results.

Conclusions
Facial nerve branch ablation is a simple surgical technique for the treatment of forehead rhytids that produces less postoperative pain, features rapid recovery, and, above all, offers long-lasting results.

Level of Evidence: 4
When the end modifies its means: the origins of novelty and the evolution of innovation
Authors: Moczek Armin P 
Published: July 2022

Abstract
The origin of novel complex traits constitutes a central yet largely unresolved challenge in evolutionary biology. Intriguingly, many of the most promising breakthroughs in understanding the genesis of evolutionary novelty in recent years have occurred not in evolutionary biology itself, but through the comparative study of development and, more recently, the interface of developmental biology and ecology. Here, I discuss how these insights are changing our understanding of what matters in the origin of novel, complex traits in ontogeny and evolution. Specifically, my essay has two major objectives. First, I discuss how the nature of developmental systems biases the production of phenotypic variation in the face of novel or stressful environments toward functional, integrated and, possibly, adaptive variants. This, in turn, allows the production of novel phenotypes to precede (rather than follow) changes in genotype and allows developmental processes that are the product of past evolution to shape evolutionary change that has yet to occur. Second, I explore how this nature of developmental systems has itself evolved over time, increasing the repertoire of ontogenies to pursue a wider range of objectives across an expanding range of conditions, thereby creating an increasingly extensive affordance landscape in development and developmental evolution. Developmental systems and their evolution can thus be viewed as dynamic processes that modify their own means across ontogeny and phylogeny. The study of these dynamics necessitates more than the strict reductionist approach that currently dominates the fields of developmental and evolutionary developmental biology.
Shared Parental Leave: Can Transferable Maternity Leave Ever Encourage Fathers to Care?
Authors: Mitchell Gemma 
Published: July 2022

Abstract
Shared parental leave made some maternity leave transferable in the UK. The aim was to improve the position of working parents, particularly mothers, by encouraging fathers to take on more of a caring role. It has been widely acknowledged that the legislation has failed to achieve this. This article considers whether the reasons for this failure are due to the specifics of the UK’s legislative scheme itself or the model of transferable maternity leave. Comparing the experience of other countries with transferable maternity leave shows that solving many of the issues with the UK legislation would not be enough to encourage fathers to care. Instead, such comparison shows that the model of transferable maternity leave can never be the most effective tool to encourage fathers to care because it will always prioritise mothers’ caring role.
Ordering as an Alternative to Indirect Co-Perpetration
Authors: Block Johannes 
Published: July 2022

Abstract
This article explores the issue of leadership criminality with a view to construing it as ordering liability under Article 25(3)(b) of the ICC Statute. It outlines the requirements of ordering liability as they can be deduced from the practice of international criminal tribunals and the International Criminal Court. In a case study, it applies these criteria to the conduct of Bosco Ntaganda to ascertain whether he could have been convicted for ordering crimes. Based on the case study, the article discusses whether ordering, as a form of criminal responsibility, should be preferred to the theory of indirect (co-)perpetration.
Proteomic and miRNA profiling of radon-induced skin damage in mice: FASN regulated by miRNAs
Authors: Mo Wei , Xu Wanglei , Hong Min , Yang Tingyi , Shi Yuhong , Jiao Yang , Nie Jihua , Cui Fengmei , Cao Jianping , Zhang Shuyu 
Published: July 2022

Abstract
Radon is a naturally occurring radioactive gas and considered as a serious carcinogen to humans. Continuous radioactive decay of this gas emits high-energy alpha particles. Long-term radon exposure induces oxidative stress and inflammatory response, which results in chronic lung diseases. However, biological effects after radon exposure in other organs have been rarely reported. As the outermost organ of the human body, the skin suffers from environmental damage to agents such as air pollution. Epidemiological studies indicated that areas with high level of radon had a high incidence of skin cancer. However, whether radon exposure induces skin damage has not been reported yet. In this study, we established a radon-exposed mouse model and found that radon exposure affected the structure of skin tissues, which was manifested by inflammatory cell infiltration and skin atrophy. Using proteomic approach, we found 45 preferentially expressed proteins in 60 Working Level Months (WLM) group and 314 preferentially expressed proteins in 120 WLM group from radon-exposed skin tissues. Through microRNA (miRNA) sequencing profiling analysis, 57 dysregulated miRNAs were screened between the control and radon-treated mouse skin. By integrating the dysregulated proteins and miRNAs, radon-induced fatty acid synthase (FASN) was investigated in greater detail. Results showed that FASN was regulated by miR-206-3p and miR-378a-3p and involved in the pathogenesis of radon-induced skin damage. Overexpression of FASN inhibited the proliferation, and induced in WS1 cells. Our present findings illustrate the molecular change during radon-induced skin damage and the potential role of FASN during this process.
What is the ideal management of Krukenberg syndrome?
Authors: Arró Ortiz Carolina , Ramallo Darío , Guerrini Nicolás 
Published: July 2022

Abstract
We present the case of a 34-year-old female patient diagnosed with Krukenberg Syndrome, in which we performed total cytoreduction surgery of the lesions, with subsequent perioperative chemotherapy. After a follow-up of three years, we observe she continues without evidence of disease. In the early 1990’s Sugarbaker et al. introduced cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) as a new innovative therapy option for selected patients with peritoneal carcinomatosis. Nowadays, there is no established treatment for patients with peritoneal metastasis of colorectal cancer. There is a need for the future high-quality randomized multicenter trials to make a strong recommendation.
Does the Reader Fear God for Nothing?
Authors: Schwáb Zoltán 
Published: July 2022

Abstract
God’s speeches in Job 38–41 have been criticized by some for their arrogant tone and celebrated by others for their non-anthropocentric worldview. While these interpretations address important features of the text, they are too simple. Rather than having a non-anthropocentric perspective, God hides his fascination with Job in order to raise him to a new level of selflessness. Similarly, rather than simply being arrogant, God hides his care for Job, which also serves a pedagogical purpose. God wants Job to experience a completely unselfish fear of his maker that does not expect anything in exchange, not even God’s loving attention. While readers reflect on Job’s response, they also reflect on their own: are they willing to fear God for nothing in return?
In vitro and in vivo studies on bacteria and encrustation resistance of heparin/poly-L-lysine-Cu nanoparticles coating mediated by PDA for ureteral stent application
Authors: Awonusi Bukola O , Li Jianzhong , Li Hongwei , Wang Zhenyu , Yang Ke , Zhao Jing 
Published: July 2022

Abstract
Ureteral stents are commonly utilized as a medical device to aid the flow of urine. However, biofilm formation and encrustation complications have been clinical problems. To overcome this challenge, heparin/poly-L-lysine-copper (Hep/PLL-Cu) nanoparticle was immobilized on a dopamine-coated polyurethane surface (PU/NPs). The stability and structural properties of the nanoparticles were characterized by Zeta potential, poly dispersion index, transmission electron microscopy, atom force microscopy and contact angle. The surface composition, antibacterial potency, encrustation resistance rate and biocompatibility of PU/NPs were investigated by scanning electron microscope, X-ray photoelectron spectroscopy, antibacterial assay and MTS assay, respectively. In addition, the anti-encrustation property was studied by implanting coated NPs stents in the rat bladder for 7 days. It was shown that the size and distribution of Hep/PLL-Cu nanoparticles were uniform. PU/NPs could inhibit Proteus mirabilis proliferation and biofilm formation, and exhibit no cytotoxicity. Less encrustation (Ca and Mg salt) was deposited both in vitro and in vivo on samples, demonstrating that the NPs coating could be a potential surface modification method of ureteral material for clinical use.
Maternal blood metal concentrations are associated with C-reactive protein and cell adhesion molecules among pregnant women in Puerto Rico
Authors: Kim Christine , Cathey Amber L. , Watkins Deborah J. , Mukherjee Bhramar , Rosario-Pabón Zaira Y. , Vélez-Vega Carmen M. , Alshawabkeh Akram N. , Cordero José F. , Meeker John D. 
Published: July 2022

Background:
Studies have revealed a link between aberrant levels of maternal C-reactive protein (CRP) and cell adhesion molecules (CAMs) with adverse birth outcomes. Some epidemiologic studies have indicated that long-term metal exposures can modulate the levels of CRP and CAMs, but the associations between prenatal metal exposures and the levels of CRP and CAMs have yet to be studied more extensively. In this study, we assessed associations between maternal blood metal levels and CRP/CAMs among 617 pregnant women in the Puerto Rico PROTECT birth cohort.

Methods:
Blood samples were collected from participants at 16–20 (visit 1) and 24–28 (visit 3) weeks gestation. We measured concentrations of 11 metals using inductively coupled plasma mass spectrometry (ICP-MS). From the blood samples, CRP and CAMs intercellular adhesion molecule (ICAM) and vascular cell adhesion molecule (VCAM) were also quantified using a customized Luminex assay. Linear-mixed effects models (LMEs) were used to regress CRP and CAMs on metals and included random intercepts for study participants to account for correlated repeated outcome measures. Fetal sex and visit effects were estimated using interaction terms between metal exposure variables and fetal sex, as well as visit indicators, respectively.

Results:
We observed significant positive associations between nickel and CRP (Δ: 7.04, 95% CI = 0.75, 13.73) and between lead and VCAM (Δ: 4.57, 95% CI = 1.36, 7.89). The positive associations were mainly driven by mothers carrying male fetuses. We also observed various visit-specific associations. The significant associations between metals and CRP were predominantly driven by visit 3; however, the significant associations between metals and VCAM were mainly driven by visit 1.

Conclusion:
Certain maternal blood metal levels were significantly associated with CRP and CAMs and most of these associations were differentially driven by fetal sex, as well as by timing in pregnancy. Future studies should further explore metal-CRP/CAMs associations for a better understanding of the underlying mechanism of metal-induced adverse birth outcomes.
QUANTITATIVE ANALYSIS OF CHORIOCAPILLARIS ALTERATIONS IN SWEPT-SOURCE OPTICAL COHERENCE TOMOGRAPHY-ANGIOGRAPHY DURING RADIATION RETINOPATHY
Authors: Gilli Christelle , Kodjikian Laurent , Loria Olivier , Jabour Charles , Rosier Laurence , Nhari Maxime , Nguyen Anh Minh , Herault Joël , Thariat Juliette , Salleron Julia , Mathis Thibaud 
Published: July 2022

Purpose:
To evaluate choriocapillaris alterations following proton beam therapy irradiation using swept-source optical coherence tomography-angiography, and to assess their correlation with the grade of radiation retinopathy (RR).

Methods:
Eyes with uveal melanoma evaluated before and after irradiation with proton beam therapy were included, as well as the healthy fellow eye. The gradation of RR was based on a previously published classification. Choriocapillaris flow voids area was analyzed using Phansalkar thresholding. Retinal vascularization was described by foveal avascular zone (FAZ) perimeter, FAZ area, FAZ circularity index, and percentage of nonperfusion area (PAN) in the superficial capillary plexus (SCP) or deep capillary plexus.

Results:
A total of 157 eyes of 83 patients were analyzed. Overall, there was a significant difference between the control group, the uveal melanoma before proton beam therapy group, and the grades of RR in the uveal melanoma after proton beam therapy group for FAZ perimeter (P < 0.001), FAZ area (P < 0.001), FAZ-circularity index (P < 0.001), PAN-SCP (P < 0.001), PAN-deep capillary plexus (P < 0.001), and choriocapillaris flow voids area (P < 0.001). Moreover, choriocapillaris flow voids area was significantly increased in the early stages of RR (P = 0.003) and was further significantly correlated with FAZ perimeter (P < 0.001), FAZ area (P < 0.001), FAZ-circularity index (P = 0.010), PAN-SCP (P < 0.001), and PAN-deep capillary plexus (P < 0.001).

Conclusion:
Quantitative optical coherence tomography-angiography alterations in the choriocapillaris microvascularization are an early biomarker of RR and are correlated to the severity of the disease.
Neonatal nurse practitioner job satisfaction, workforce environment, and mental well-being
Authors: Snapp Barbara , McCutchon Elizabeth Welch , Moore Tiffany A. , Teel Dedra 
Published: July 2022

ABSTRACT

Background:
Increased demand for nurse practitioners emphasizes the importance of consistent and ongoing collection of data to provide a better understanding of the NNP workforce and to promote retention and recruitment of NNPs.

Purpose:
To understand how work environment and work hours influence job or career satisfaction.

Methodology:
The National Association of Neonatal Nurse Practitioners in collaboration with the National Certification Corporation emailed an online survey to all 6,558 certified neonatal nurse practitioners (NNPs) in 2020 with 845 (12.8%) responding. Subjects included those with responsibilities in direct patient care, transport NPs, faculty/directors, and advanced practice registered nurse coordinators/managers/administrators.

Results:
Satisfaction with career choice as an NNP was reported as very satisfied by 58% (n = 493) and mostly satisfied by 37% (n = 310). Satisfaction with current job as an NNP was reported as very satisfied for 30% (n = 252), with 51% being mostly satisfied (n = 435). Age influenced satisfaction scores, with NNPs aged 61 years or older having a higher mean score than NNPs aged 31–40 years (p = .041). The majority of NNPs did not use all of their available paid time off (72%; n = 609) and respondents worked an additional 248 extra hours per year. NNPs experience bullying (58%) and/or lateral violence (32%). Seventeen percent have called in sick for mental health reasons (n = 147).

Conclusions:
Neonatal nurse practitioners' satisfaction is multifactorial. Those who reported taking time off for self-prescribed mental health indicated less job satisfaction, more work hours, poor work/life balance, and a less-than-optimum work environment.

Implications:
Overall, NNPs are satisfied with their career choice but are less satisfied with their job choice. Understanding factors that influence mental well-being and job satisfaction will improve recruitment and retention of nurse practitioners.
Progress in pediatric obesity: new and advanced therapies
Authors: Cuda Suzanne , Censani Marisa 
Published: July 2022

Purpose of review
In this review, we discuss new medical and surgical options for the treatment of children and adolescents with obesity. We review the impact of COVID-19 on this vulnerable population. We also discuss the recent availability of screening tests for rare genetic causes of obesity.

Recent findings
COVID-19 increased the prevalence of obesity among children and adolescents. This population is at increased risk for severe disease. The field of pediatric obesity has benefited from the approval of two new antiobesity medications: liraglutide and setmelanotide. We discuss indications for their use. New guidelines for surgical options for the treatment of children and adolescents with obesity are reviewed. These options are increasingly used as part of the comprehensive care for these children.

Summary
The epidemic of childhood obesity continues. COVID-19 and the associated isolation contributed to the problem. However, promising new medical and surgical therapies and screening tests for rare genetic causes of obesity are available. These new diagnostic and therapeutic options bring renewed enthusiasm to the treatment of children and adolescents with obesity and increased recognition that obesity is a chronic disease starting in childhood deserving intervention to prevent consequences.
iOBPdb – A Database for Experimentally Determined Functional Characterization of Odorant Binding Proteins
Authors: Shukla Shalabh , Nakano-Baker Oliver , MacKenzie Devin , Sarikaya Mehmet 
Published: July 2022

Summary/AbstractOdorant binding proteins, OBPs, are a diverse family of small, globular, extra-cellular proteins solubilize volatile organic compounds (VOCs) so they can be internalized and transported by an organism. Since their initial discovery in the early eighties 1, thousands of OBPs have been identified through genome sequencing and characterized by fluorescence ligand binding assays 2. While individual OBPs have been studied in the context of their roles in specific organism, there have been no studies towards the understanding of the comparative structure-function relations of all known OBPs, primarily due to a lack of a centralized database that incorporates the binding affinity with the structure of all OBPs. Incorporating OBP information into a database requires not only an extensive search of all existing resources, but also creating a useful platform that relates sequence structures to target functions. Combining 215 functional studies containing 381 unique OBPs from 91 insect species we created a database, iOBPdb: https://iobpdb.herokuapp.com, of OBP binding affinities for a wide range of VOC targets. We demonstrate here that the construction of this initial database provides powerful search and associative capabilities including interrogating odor binding proteins as clusters and groups by sequence similarity versus protein and target molecular weights, and by the functional groups of the VOC targets. The comparative interrogation of the probe-target recognition allows for a more comprehensive understanding of the underlying structural features of all OBPs that had not been possible by only examining the OBPs individually. We present our results in a variety of phylogenetic representations as well as providing the binding profiles of OBP groups to VOC functional moieties. Potential applications include development of molecular probes for biosensors, novel bioassays and drugs, discovery of novel pesticides which inhibit VOC / OBP interactions, as well providing a foundational basis for the functional understanding of odor sensing and perception in the brain.Abstract Figure