bluuebunny/crossref_metadata_2025_split huggingface dataset:
Latinx fathers of transgender and gender diverse people: Journey toward acceptance and role of culture
Authors: Teran Manuel , Abreu Roberto L. , Tseung Emily S. , Castellanos Jeanett 
Published: November 2022

AbstractObjectiveThis article reports on a qualitative study, phenomenological approach, with a sample of Latinx fathers of transgender and gender‐diverse people.BackgroundResearch shows that acceptance by parental figures is crucial for the development and well‐being of transgender and gender diverse people. However, little research has focused on the experiences of fathers. Specific to Latinx fathers, cultural values, beliefs, and traditions might be instrumental in their journey toward accepting their transgender and gender diverse child.MethodsA descriptive, phenomenological approach was used in this study with Latinx fathers (N = 8). In‐depth, semistructured interviews were completed to explore the lived experiences of the fathers.ResultsQualitative analysis yielded seven main themes: (a) fear of safety and desire to protect child; (b) difficulties adjusting to child's identity; (c) seeking out information and support from other Latinx families; (d) understanding, respect, and empathy; (e) increased sense of involvement and responsibility on LGBTQ+ issues; (f) positive transformation at multiple levels; and (g) influence of Latinx cultural values and beliefs.ImplicationsFindings provide important clinical implications for practitioners, such as creating room for Latinx fathers to process and explore how different Latinx cultural values (e.g., familismo, machismo, caballerismo, religion and spirituality) might facilitate or hinder acceptance of their transgender and gender diverse child.
A qualitative study of the capabilities of family members of veterans living with operational stress injuries
Authors: Norris Deborah , Schwartz Kelly Dean , Eichler Maya , Tam‐Seto Linna , Mahar Alyson , Smith‐Evans Kimberley , Cramm Heidi 
Published: November 2022

AbstractObjectiveThis qualitative study explores the experiences of 26 family members supporting Canadian Armed Forces veterans living with mental health problems including operational stress injuries (OSIs).BackgroundThe research focusing on military‐connected families emphasizes the impacts of service on the families. Little is known about how families impact military veterans, particularly those diagnosed with OSIs. This research addresses that gap by revealing the capabilities and demands characterizing their everyday lives.MethodSemistructured interviews with 26 individuals identifying as family members of Canadian Armed Forces (CAF) veterans and three focus groups (three participants in each group for a total of nine) with family members of CAF veterans released within the preceding 10 years were conducted. The veterans were living with broadly defined diagnosed and undiagnosed mental health problems including OSIs. Using the family adjustment and adaptation (FAAR) model as an organizational framework, demands and capabilities embodied within the everyday lives of the family members were revealed.ResultsMonitoring the well‐being of the veteran, managing daily life, accessing and mobilizing resources, and caregiving were discussed as capabilities by participants in this study. These capabilities buffer the demands associated with the veteran's mental health problems.ConclusionsResults of this study endorse recommendations for family‐centered program and service development, modeled on approaches that recognize the systemic and relational contexts instrumental in supporting positive outcomes for veterans with OSIs.ImplicationsFurther research exploring the complex, interdependent, and interactional role of families supporting veterans with OSIs is warranted.
Is helicopter parenting related to college students’ mental health? A typological and cross‐cultural approach
Authors: Hwang Woosang , Jung Eunjoo , Fu Xiaoyu , Zhang Yue , Ko Kwangman , Lee Sun‐A , Lee Youn Mi , Lee Soyoung , You Hyun‐Kyung , Kang Youngjin 
Published: November 2022

AbstractObjectiveThe goal of this study is to uncover latent classes of maternal and paternal helicopter parenting among American and Chinese college students, and to examine whether latent classes of maternal and paternal helicopter parenting are related to college students’ mental health (depression and self‐esteem).BackgroundPrevious studies have examined the association between helicopter parenting and college students’ well‐being. However, less is known about how the multidimensional construct of helicopter parenting is related to college students’ mental health across Western and Eastern cultural contexts.MethodWe conducted three‐step latent class analyses using nine helicopter parenting indicators for 1,386 mother–child and 1,214 father–child groups in the United States and 520 mother–child and 454 father–child groups in China. Next, we tested the association between the class membership of maternal and paternal helicopter parenting and college students’ mental health.ResultsWe identified distinct helicopter parenting latent classes among four American and Chinese parent–child groups. We also found that American college students in the strong maternal helicopter parenting latent class reported poorer mental health than those in other latent classes.ConclusionOur findings indicate that the multidimensional construct of helicopter parenting can be interpreted differently by parents and college‐aged children according to their social and cultural contexts.ImplicationsThe findings of this study suggest that it is necessary to strengthen understanding of the multidimensional construct of helicopter parenting for parents with college‐aged children to enable them to develop more appropriate parenting practices as well as support their children's well‐being.
Homogenisation of water and sediment bacterial communities in a shallow lake (lake Balihe, China)
Authors: Zhong Meifang , Capo Eric , Zhang Huayong , Hu Haiyan , Wang Zhongyu , Tian Wang , Huang Tousheng , Bertilsson Stefan 
Published: November 2022

Abstract

Planktonic and benthic bacterial communities hold central roles in the functioning of freshwater ecosystems and mediate key ecosystem services such as primary production and nutrient remineralisation. Although it is clear that such communities vary in composition both within and between lakes, the environmental factors and processes shaping the diversity and composition of freshwater bacteria are still not fully understood.

In order to assess seasonal and spatial variability in lake bacterial communities and identify environmental factors underpinning biogeographical patterns, we performed a large‐scale sampling campaign with paired water and sediment sample collection at 18 locations during four seasons in Lake Balihe, a subtropical shallow fish‐farming lake in mid‐eastern China.

Pelagic and benthic bacterial communities were distinctly different in terms of diversity, taxonomic composition and community structure, with Actinobacteria, Bacteroidetes, Cyanobacteria and Alphaproteobacteria dominating lake water, and Acidobacteria, Bacteroidetes, Chloroflexi, Gammaproteobacteria and Deltaproteobacteria dominating sediment. Nevertheless, these two communities had stronger spatial concordance and overlap in taxa during spring and autumn seasons. Together, the main drivers of both the spatial and temporal variations in Lake Balihe bacterial communities were identified as water temperature, turbidity, nitrogen and phosphorus availability, and thermal stratification controlled by wind‐mixing and activity of the dense farmed fish populations. Notably, populations affiliated with Firmicutes, known to be abundant in fish gut microbiome, were especially abundant in the summer season and locations where high fish biomass was found, suggesting a potential link between fish gut microbiome and the pelagic bacterial communities.

Our findings demonstrated seasonal homogenisation of pelagic and benthic bacterial communities linked to marked shifts in a set of seasonally‐driven environmental variables including water temperature and nutrient availability.
Migraine in the context of chronic primary pain, chronic overlapping pain disorders, and functional somatic disorders: A narrative review
Authors: Henningsen Peter , Hausteiner‐Wiehle Constanze , Häuser Winfried 
Published: November 2022

AbstractObjectiveTo contextualize migraine as the most common primary headache disorder in relation to other chronic primary pain and non‐pain functional somatic and mental conditions.BackgroundMigraine is increasingly understood as a sensory processing disorder within a broader spectrum of symptom disorders. This has implications for diagnosis and treatment.MethodNarrative review based on a search of the literature of the last 15 years on the overlap of migraine with other symptom disorders.ResultsMigraine as the prototypical primary headache disorder not only comprises many non‐headache symptoms in itself, it also shows high comorbidity with other chronic pain and non‐pain conditions (e.g., fibromyalgia syndrome, irritable bowel syndrome, functional non‐epileptic seizures, depression, anxiety, and posttraumatic stress disorder). Such “symptom disorders” share several etiological factors (e.g., female preponderance, psychological vulnerability) and psychophysiological mechanisms (e.g., altered sensory processing, pain expectancy). These facts are acknowledged by several recent integrative conceptualizations such as chronic primary pain, chronic overlapping pain conditions, or functional somatic disorders. Accordingly, migraine management increasingly addresses the total symptom burden and individual contributors to symptom experience, and thus incorporates centrally acting pharmacological and non‐pharmacological, that is, psychological and behavioral, treatment approaches.ConclusionsMigraine and also other primary headache disorders should be seen as particular phenotypes within a broader spectrum of symptom perception and processing disorders that require integrative diagnostics and treatment. A harmonization of classifications and better interdisciplinary collaboration are desirable.
Different dosage regimens of erenumab for the treatment of migraine: A systematic review and meta‐analysis of the efficacy and safety of randomized controlled trials
Authors: Gui Tiantian , Li Hao , Zhu Feng , Wang Quan , Zhou Xiaoling , Xue Qun 
Published: November 2022

AbstractBackgroundMigraine is a worldwide epidemic neurological disorder that has a significant influence on the quality of life. Migraine attacks are considered to be related to a calcitonin gene‐related peptide (CGRP) signaling molecule, and anti‐CGRP medications are used to abort and prevent migraine attacks. Erenumab, a monoclonal antibody that targets the CGRP receptor, is the first migraine preventive medication approved by the US Food and Drug Administration. In the present study, we evaluate the efficacy and safety of erenumab.ObjectiveThis study aims to systematically assess the efficacy and safety of erenumab as a migraine preventive treatment compared to a placebo.MethodsRandomized, placebo‐controlled, single or double‐blind trials were searched through MEDLINE, Embase, Cochrane Library, andClinicalTrials.govup to May 2022. The efficacy outcomes we collected include changes from baseline on monthly migraine days, monthly acute migraine‐specific medication days, ≥50% responder rate, ≥75% responder rate, and 100% responder rate at week 12. Safety outcomes include treatment emergent adverse events, serious adverse events, and any adverse event that leads to discontinuation of treatment. The study was registered with PROSPERO (Registry number: CRD42022338861).ResultIn all eight included trials, we found that erenumab (28, 70, and 140 mg) is very effective and has a significantly greater reduction in baseline monthly migraine days (28 mg: mean difference [MD] = −1.1, 95% confidence interval [CI]: −2.0 to −0.2,p = 0.020; 70 mg: MD = −1.4, 95% CI: −1.8 to −1.1,p < 0.001,I2 = 26%; 140 mg: MD = −1.8, 95% CI: −2.1 to −1.4,p < 0.001,I2 = 0%) than placebo at week 12, especially with 140 mg. Otherwise, we found that there were no statistical differences in the occurrence of adverse events (7 mg: risk ratio [RR] = 0.9, 95% CI: 0.7 to 1.2,p = 0.570; 21 mg: RR = 1.0, 95% CI: 0.8 to 1.2,p = 0.730; 28 mg: RR = 0.9, 95% CI: 0.7 to 1.1,p = 0.340; 70 mg: RR = 1.0, 95% CI: 0.9 to 1.0,p = 0.230,I2 = 0%; 140 mg: RR = 1.0, 95% CI: 0.9 to 1.1,p = 0.880,I2 = 40%) between the erenumab and placebo groups.ConclusionsIn our study, we found that erenumab, especially at the dose of 140 mg, is an effective and well‐tolerated preventive treatment for migraine.
Results from an extended study on the reliability of a questionnaire for the diagnosis of sensitive skin: Confirmations and improvements
Authors: Borghi Alessandro , Guarneri Fabrizio , Montesi Leda , Pacetti Lucrezia , Donelli Irene , Corazza Monica 
Published: November 2022

AbstractObjectiveA recently proposed self‐assessment questionnaire aimed at diagnosing sensitive skin provided promising results in a relatively small population. The main objectives were: (i) to assess the reliability of the aforementioned questionnaire in a larger population and verify the cut‐off score previously found to predict skin sensitivity (defined as positivity to LAST, lactic acid stinging test) and (ii) to define a formula that yields the probability of a positive LAST result.MethodsAdult volunteers were included in this observational, cross‐sectional, extended study. Both LAST‐positive subjects, who were considered as having sensitive skin (‘patients’) and negative ones (‘controls’) completed the questionnaire, which concerned sensitivity to possible triggers of unpleasant skin sensations in real life. A cumulative score (questionnaire‐based skin sensitivity score, 0–10) was calculated from the sum of all items.ResultsThree hundred and sixty‐four subjects were enrolled, 214 patients and 150 controls. The mean questionnaire‐based skin sensitivity score was significantly higher among patients than controls. Using two different methods, cut‐off values of 4 and 5 were defined for the identification of LAST‐positive subjects, with 76.6% and 72.8% accuracy, respectively. Scores below 4 or above 5 showed a high (80% or better) negative or positive predictive value, respectively. The coefficients found that in multivariate analysis for each questionnaire item, gender and age allowed us to calculate the probability of LAST positivity with higher precision taking into account the ‘relative weight’ of each factor.ConclusionWith small variations in the results, the self‐assessment questionnaire confirmed its reliability for diagnosing sensitive skin in clinical practice.
Preclinical study probing primary stability of dental implants in synthetic and natural bones
Authors: Shetty Vibha , S Santhosh Kumar , Mishra Deepa , N Rakesh , Barui Srimanta , Basu Bikramjit 
Published: November 2022

AbstractThe natural bone is a biological example of a polymer–ceramic composite with a higher volume fraction of nanosized ceramic (around 65% hydroxyapatite) dispersed in polymer (collagenous) matrix. The loading of a dental implant involves the biomechanical interactions of the implant with such natural composites in the jaw bones of human subjects. In particular, the insertion torque responses of the dental implant are related to the implant design, in particular the external thread morphology, which influences the primary stability of the implant. In this study, the effect of the bone properties (polyurethane‐based synthetic bone, porcine and human cadaver lumbar bone) and clinically relevant implant driving protocols on the insertion and removal torques of newly designed implant variants (hybrid threads with macro‐ and micro‐threads) were assessed, quantitatively and qualitatively. It was observed that torque response increased with an increase in bone density, irrespective of the implant designs. The torque response of the implants in both synthetic and natural bones was benchmarked with the commercially available implant. The implants with bone cutting partial macro‐threads at the apical end without inter thread gap exhibited comparable clinically relevant results with respect to control implants and were found to be most suitable for implantation into natural bone.
Utilisation of flavonoids from Lycium barbarum L. leaves cross‐linked with whey protein for the stabilisation and delivery of β‐carotene emulsions
Authors: Fan Yanli , Sun Xiazhi , Fang Tian , Ma Maimai , Wu Yuxing , Zha Xiaotong 
Published: November 2022

SummaryAlthough β‐carotene is an essential nutrient for the maintenance of human health, it is insoluble in water and extremely unstable, which limits its application. Here, we prepared a stable emulsification system of whey protein (WP)‐Lycium barbarum L. leaves flavonoids (LBLF) complex as a carrier to load β‐carotene. The rheological properties, antioxidant properties and stability of emulsion were studied, and the effects of emulsion on the biological retention of β‐carotene and stability were investigated. The results indicate that, compared with WP, the WP‐LBLF emulsion has smaller particles, a smaller creaming index, and significantly enhanced chemical stability under light and heat treatment conditions. The thiobarbituric acid value of the WP‐LBLF emulsion (0.031 ± 0.016 mg/kg) was dramatically lower than that of the WP emulsion (0.045 ± 0.012 mg/kg) (P < 0.05). In the simulated gastrointestinal digestion experiment, the retention rate of β‐carotene was higher in WP‐LBLF emulsion. Additionally, the WP‐LBLF emulsion loaded with β‐carotene has good salt tolerance and heat stability. In our study, WP‐LBLF was used as an emulsifier to load β‐carotene emulsion to improve its bioavailability and stability, which provides a new preparation and application method for a complex functional emulsifier.
Androgen deprivation therapy duration is significantly associated with Testosterone recovery in Japanese patients with prostate cancer
Authors: Arai Masashi , Kosaka Takeo , Yasumizu Yota , Takeda Toshikazu , Matsumoto Kazuhiro , Oya Mototsugu 
Published: November 2022

ObjectiveDue to the fear generated by COVID‐19 in Spring 2020, many patients postponed their scheduled outpatient visits. To differentiate those patients with prostate cancer (PCa) whose androgen deprivation therapy (ADT) injection treatment can be postponed, we investigated the characteristics of testosterone (T) recovery in Japanese patients after they received combined ADT and radiation therapy (RT).MethodsWe included 81 patients with PCa treated with ADT and RT at Keio University Hospital from January 2013 to December 2018. T‐recovery was defined as the time interval between the last ADT injection and 3–6 months after T‐normalization. The Kaplan–Meier method was used to estimate time to T‐recovery. Cox proportional hazards models identified T‐recovery predictors.ResultsThe 50% cumulative incidence of T‐recovery was 7.0 months for the 6‐short‐term group (defined as patients having ≤6 months of ADT therapy) versus 13.0 months for the 6‐long‐term group (>6 months of therapy) (p < 0.001). The incidence was 7.0 months for the 12 short‐term‐ADT (ST) group versus 18.0 months for the 12 long‐term‐ADT (LT) group (p < 0.001). Multivariate analysis revealed that a shorter duration of ADT was associated with a shorter time to T‐recovery (hazard ratio, 0.253; 95% CI, 0.138–0.465; p < 0.001). No other factors were significant predictors of T‐recovery.ConclusionAndrogen deprivation therapy duration is significantly associated with T‐recovery in Japanese patients with PCa. If a patient undergoes ADT for more than 6 or 12 months, it is possible to postpone their outpatient visits for 13 and 18 months, respectively.
Chemical modification of acellular fish skin as a promising biological scaffold by carbodiimide cross‐linker for wound healing
Authors: Abbasnezhad Sara , Biazar Esmaeil , Aavani Farzaneh , Kamalvand Mahshad , Heidari Keshel Saeed , Pourjabbar Bahareh 
Published: November 2022

AbstractBiological matrices can be modified with cross‐linkers to improve some of their characteristics as scaffolds for tissue engineering. In this study, chemical cross‐linker 1‐Ethyl‐3‐(3‐dimethylaminopropyl) carbodiimide (EDC) was used with different ratios (5, 10, 20, 30, and 40 mM) to improve properties such as mechanical strength, denaturation temperature, and degradability of the acellular fish skin as a biological scaffold for tissue engineering applications. Morphological analysis showed that the use of cross‐linker at low concentrations had no effect on the structure and textiles of the scaffold, while increasing mechanical strength, denaturation temperature, and degradation time. Cytotoxicity and cellular studies showed that the optimal cross‐linker concentration did not significantly affect cell viability as well as cell adhesion. In general, utilising the carbodiimide cross‐linker with the optimal ratio can improve the characteristics and function of the biological tissues such as acellular fish skin.
Effects of textual prompting and constant time delay on social communication skills of young adults with Prader Willi syndrome during online socialisation activities
Authors: Vascelli Luca , Berardo Federica , Iacomini Silvia , Scorza Maristella , Cavallini Francesca 
Published: November 2022

AbstractBackgroundSocial communication skills are critical for full participation in social activities in primary life contexts for adolescents and young adults with neurodevelopmental disorders.MethodTwo young adults with Prader Willi syndrome participated in an online socialisation programme with elderly and adolescent conversational partners. We used a multiple baseline across conversational partners design for each participant to investigate the effects of textual prompts and constant time delay on the number of initiations and follow‐up questions. We evaluated the social validity.ResultsBoth participants improved their social communication skills during online socialisation with partners. Participants with Prader Willi syndrome enjoyed participating in this study. Elderly conversational partners reported a slight decrease in loneliness following online socialisation.ConclusionThe use of textual prompts and constant time delay may be helpful to promote opportunities for interaction among segments of the population potentially at risk of social isolation during online socialisation.