bluuebunny/crossref_metadata_2025_split huggingface dataset:
Integrating Core and Aeromagnetic Datasets to Evaluate Mineral Potential of Southern Nupe Basin, Nigeria
Authors: Usman Ayatu , Azuoko Geogerbest , Chizoba Joshua , Chinwuko Ifeanyi 
Published: January 2022

Abstract
Aeromagnetic and core drilled data covering parts of southern Nupe Basin was acquired and interpreted with the view to evaluating the mineral potentials of the area through interpretation of the structural features in the area; determination of the curie isotherm depth; and correlation of aeromagnetic outcomes with the core sample data from the area. Two major regional fault trends were interpreted, trending, Northeast–Southwest (NE–SW) and NNE–SSW with minor northwest–southeast (NW–SE) directions. Two depth sources in the area are delineated namely; zone of shallow seated basement which ranges from 0.42km to 1.5km and zone of deeply seated basement which ranges from 1.91 to 3.50km.Results of qualitative interpretation of the Total magnetic intensity map (TMI) and Residual intensity map reveal that the magnetic intensities ranges from 7500 to 8460 nano-Telsa (nT) and -220 to 240 nT respectively. The depth to the centroid and top of the magnetic caustic bodies ranges from 9.00 to 17.10km and 0.4 to 3.10km respectively. Juxtaposing the topographical and core drilling data reveals that the oolitic iron ore level follows the topographical level which implies that the topography of the area controls the configuration of the iron ore deposit level. All these deduction are made considering the geology of the area.
Influence of Welding Parameters On Grain Size, Haz and Degree of Dilution in 6063-t5 Alloy. Optimisation Through the Taguchi Method of the Gmaw Welding Process.
Authors: Valdenebro Jose Luis Meseguer , Conesa Eusebio José Martínez , Portoles Antonio 
Published: January 2022

Abstract
The aim of this work is to carry out the design of experiments that determine the influence of the welding parameters using Taguchi’s method on the grain size, HAZ, and the degree of dilution in 6063-T5 alloy. The welding process used is GMAW and the welding parameters are power, welding speed and bevel spacing. The study of the influence of the welding parameters on the measurements made in the welding (which are the size of heat affected zone, the degree of dilution, and the grain size) allows one to determine the quality of the joint . In addition, the welding parameter most influential in minimising the three measurements will be determined.
Deep Learning Classification of Active Tuberculosis Using Chest X-Rays: Efficacy of Transfer Learning and Generalization Performance of Cross-Population Datasets
Authors: Devasia James , Goswami Hridyanand , Lakshminarayanan Subitha , Rajaram Manju , Adithan Subathra , Bharanidharan Ambalavanan 
Published: January 2022

Abstract
Chest X-ray based diagnosis of active Tuberculosis (TB) is one of the oldest ubiquitous tests in medical practice. Artificial Intelligence (AI) based automated detection of abnormality in chest radiography is crucial in radiology workflow. Most deep convolutional neural networks (DCNN) for diagnosing TB by transfer learning from natural images and using the same dataset to evaluate the model performance and diagnostic accuracy. However, dataset shift is a known issue in predictive models in AI, which is unexplored. In this work, we fine-tuned, validated, and tested two benchmark architectures and utilized the transfer learning methodology to measure the diagnostic accuracy on cross-population datasets. We achieved remarkable calcification accuracy of 100% and area under the receiver operating characteristic (AUC) 1.000 [1.000 – 1.000] (with a sensitivity 0.985 [0.971 – 1.000] and a specificity of 0.986 [0.971 – 1.000]) on intramural test set, but significant drop in extramural test set. Accuracy on various extramural test sets varies 50% - 70%, AUC ranges 0.527 – 0.865 (sensitivity and specificity fluctuate 0.394 – 0.995 and 0.443 – 0.864 respectively). Diagnostic performance on the intramural test set observed in this study shows that DCNN can accurately classify active TB and normal chest radiographs, however the external test set shows DCNN is less likely to generalize well on models trained on specific population dataset.
Metabolomics Study with Gas Chromatography-Mass Spectrometry of Hepatotoxicity on Adult Zebrafish (Brachydanio Rerio) after Exposure to Diquat
Authors: Xiao Ye , Lin Xiang , Liu Zhong-Qun , Zhou Mei-Lan , Ren Tian-Yu , Gao Rui-Li , Shen Wen-Jing , Wang Rong , Xie Xi , Song Yan-Ting , Hu Wen-Ting 
Published: January 2022

Abstract
Although diquat is a widely used water-soluble herbicide in the world, its toxicity to freshwater fish has not been well characterized. In this study, gas chromatography-mass spectrometry (GC-MS) based metabolomics approach combined with histopathological examination and biochemical assays was applied to comprehensively assess the hepatotoxicity in zebrafish (Brachydanio rerio) after diquat exposure at two dosages of 0.34 and 1.69 mg·L−1 for 35 days. The results indicated that 1.69 mg·L−1 diquat exposure cause serious cellular swell and vacuolization with increased nuclear abnormality, and lead to obvious disturbance of antioxidative system and dysfunction in liver; while no obvious pathological injury could be detected, and changes in liver biochemistry were less pronounced at the dose level of 0.34 mg·L−1. Multivariate statistical analysis and pattern recognition showed different GC-MS profiles of zebrafish liver following exposure to diquat, the cluster of the treated groups were both clearly separated from the control samples. The differentially abundant metabolites mainly include carbohydrates, amino acids, lipids, nucleotides, and their derivatives. In the exposure group of 1.69 mg·L−1 diquat, severe disturbances of amino acid metabolism played important biological roles associated with inhibition of energy metabolism, reduced immunity, and disorders in neurotransmitters as pathway analysis revealed. Additionally, fluctuation of inositol, creatine, and pantothenic acid, substances associated with stress regulation and signal transduction, participating in metabolic abnormalities in zebrafish with diquat-triggered hepatic damage. Energy metabolism of zebrafish exposed on 0.34 mg·L−1 diquat more inclined to rely on anaerobic glycolysis than the normal ones. Amino acid metabolism responses were less affected, but obvious interference effects on lipid metabolism were observed with 0.34 mg·L−1 diquat exposure. These results imply increased sensitivity of metabolomics versus histopathology and clinical chemistry in recognizing liver toxicity of diquat. This study will contribute to explore possible mechanism of hepatic damages on nontarget freshwater fish induced by diquat and provide important basis for its environmental risk assessment.
Comparison of Two Different Uses of Underbody Forced-air Warming Blankets for the Prevention of Hypothermia in Patients Undergoing Arthroscopic Shoulder Surgery: a Prospective Randomized Study
Authors: Yin Wenchao , Wan Qihai , Jia Haibin , Jiang Xue , Luo Chunqiong , Zhang Lan 
Published: January 2022

Abstract
Background: Forced-air warming (FAW) is an effective method of preventing inadvertent perioperative hypothermia (IPH). However, its warming effects can be influenced by the style and position of the FAW blanket. This study aimed to compare the effects of underbody FAW blankets being placed under or over patients in preventing IPH.Methods: Patients (n=100) undergoing elective arthroscopic shoulder surgery in the lateral decubitus position were randomized into either under body (UB) group or the over body (OB) group (50 per group). The core body temperature (CBT) of the patients was recorded from baseline to the end of anesthesia. The incidences of postoperative hypothermia and shivering were also collected.Results: A steady decline in the CBT was observed in both groups up to 60 minutes after the start of FAW. After 60 minutes of warming, the OB group showed a gradual increase in the CBT. However, the CBT still decreased in UB group until 75 minutes, with a low of 35.7℃ ± 0.4℃. Then the CBT increased mildly and reached 35.8℃ ± 0.4℃ at 90 minutes. After 45 minutes of warming, the CBT was significantly different (P < 0.05). The incidence of postoperative hypothermia in the UB group was significantly higher than that in the OB group (P = 0.023).Conclusions: The CBT was significantly better when the underbody FAW blanket was placed over patients compared with under the patients. However, there was not a clinically significant difference in CBT. The incidence of postoperative hypothermia was much lower in the OB group. Therefore, placing underbody FAW blankets over patients is recommended for the prevention of IPH in patients undergoing arthroscopic shoulder surgery.Trial registration: This single-center, prospective, RCT has completed the registration of the Chinese Clinical Trial Center at 13/1/2021 with the registration number ChiCTR2100042071. It was conducted from 14/1/2021 to 30/10/2021 as a single, blinded trial in Sichuan Provincial Orthopedic Hospital.
The Relationship Between Social Support And Social Withdrawal Of Left-Behind Adolescents: A Chain Mediating Model
Authors: Wen Fangfang , Chen Chu , Yang Ke , Luo Zengqi , Xie Huiyi , Long Jiahui , Zuo Bin 
Published: January 2022

Abstract
Background: Nowadays, as more and more Chinese farmers in rural area went to city for work, they left their kids at home. These kids were left-behind adolescents and they developed without their parental accompany. The family function of left-behind adolescents was deficient, which may result in their social withdrawal in social situations. Therefore, in this study, in order to improve left-behind adolescents’ psychological and behavior problems, we aimed to investigate their level of social withdrawal and its impact factors. Method: There were 339 left-behind adolescents and 289 non-left-behind adolescents recruited from a Chinese junior high school. Their social withdrawal, social support, relative deprivation, and resilience were measured through questionnaires. Results: The results showed that compared with non-left-behind adolescents, left-behind adolescents had lower social support and resilience, but their social withdrawal and relative deprivation were higher; besides, left-behind adolescents’ social support negatively predicted social withdrawal, while relative deprivation and resilience played a chain mediating role between them. Conclusion: This study found that compared with none-left-behind adolescents, left-behind adolescents had difficulty in social adaptation. However, there was a “context-process-outcome” model in which social support negatively predicted social withdrawal, while relative deprivation and resilience played a chain mediating role between them. In sum, this study provided suggestions to promote the mental health and social behavioral development of left-behind adolescents.
Comparison of Animal Models for Premature Ovarian Insufficiency Induced by Different Doses of Cyclophosphamide: a Network Meta‑analysis
Authors: Qi Yiwen , Zhu Yue-meng , Li Bin 
Published: January 2022

Abstract
IntroductionCyclophosphamide (CTX), is reported to be extensively used to establish POI animal model. But the most effective dose has not been systematically concluded yet. This systematic review and network meta-analysis is aimed to compare and rank the different doses of cyclophosphamide in the CTX-induced POI rat model.MethodsRandomized controlled trials of CTX-induced rat POI model were searched in four databases from inception to December, 2021. A network meta-analysis was conducted to analyze the data of included publications. The quality assessment was assessed by SYRCLE’s risk of bias tool. Data were analyzed with STATA 15.0 and Review Manager 5.3.Result205 records were searched and a total of 14 articles met inclusion criteria, Compared by Ovarian morphological changes, estrous cycle and hormone level (FSH, E2, AMH), the loading dose of 200mg/kg CTX with the maintenance dose of 8mg/kg CTX for consecutive 14 days showed the best efficacy in inducing rat POI model.
Weighted Gene Correlation Network Analysis Applied to Identify the Immune Cell-related Hub Genes in ANCA Nephritis
Authors: Jin Juan , Zhang Di , Liang Mingzhu , He Wenfang , Zhang Jinshi 
Published: January 2022

Abstract
Background: Antineutrophil cytoplasmic antibody (ANCA) associated vasculitis (AAV) is the most common reason caused rapidly progressive glomerulonephritis worldwide. But the molecular mechanisms of ANCA - associated nephritis (AAN) have not been thoroughly expounded. So that，we aim to seek the potential molecular pathogenesis of AAN by bioinformatic.Result: Finally, four hub genes, PBK, CEP55, CCNB1 and BUB1B, were identified. These four hub geneswas verified higher in AAN than normal.Conclusion: Those four genes identified by integrated bioinformatics analysis may play a critical role in AAN. May offering a new insights and potential therapeutic to the AAN
Should the Preference-based Index Set of Values Be Country- or Disease-specific? An Analysis Using Data From Women With Symptoms of Overactive Bladder
Authors: Rocha Ana Paula Rodrigues , Brusaca Luiz Augusto , Sousa Ana Jéssica dos Santos , Oliveira Ana Beatriz , Driusso Patricia 
Published: January 2022

Abstract
Background: Overactive bladder (OAB) and urinary incontinence (UI) are common conditions among women. However, no studies have evaluated the utility value of this population using different country-specific value sets. We aimed to 1) verify the difference between the preference-based index extracted from the Short Form six dimensions (SF-6Dv1) questionnaire in women with OAB using different country-specific value sets; 2) translate and cross-culturally adapt the King's Health Questionnaire Five Dimension (KHQ-5D) into Brazilian Portuguese; and 3) examine the association between utility index obtained by the SF-6Dv1 and KHQ-5D. Methods: This cross-sectional study included 387 women over 18 years of age with OAB symptoms, divided into groups with and without UI. All participants answered the sociodemographic questionnaire, KHQ, KHQ-5D, and SF-6Dv1. To the statistical analysis a two-way mixed ANOVA was applied to verify the interaction between the presence of UI and utility index obtained from different country-specific value sets. Post-hoc multiple comparisons were applied following the main analysis. Spearman’s test was applied to verify the correlation between the utility values of SF-6Dv1 and KHQ-5D. The significance level was set at 5%. Results: We evaluated 298 women classified according to the presence of UI (119 without UI vs. 179 with UI). The main analysis showed a statistically significant interaction between the presence of UI and the utility index obtained from the different countries (p = 0.005, Cohen’s d= 0.02). The post-hoc analyses showed that there was a statistically significant main effect of the utility index obtained from different countries (p <0.001, d = 0.63) and in the presence of UI (p = 0.012, d = 0.02). The correlations between the utility indices obtained from different countries using the SF-6Dv1 and KHQ-5D were significant, positive, and small. Conclusions: The differences between the indices obtained in different countries and groups with and without UI, assessed using the SF-6Dv1, are shown. The correlation between general and specifics preference-based measures was small; therefore, the SF-6Dv1 should be used with caution in cost-utility studies for this population. We recommend that in women with OAB, the value set for GPBM be obtained in countries where cost utility is applied.
Derivation and External Validation of a Simple Prediction Rule for the Development of Respiratory Failure in Hospitalized Patients With Influenza
Authors: Ayuso Blanca , Lalueza Antonio , Arrieta Estibaliz , Romay Eva Maria , Marchán-López Álvaro , García-Pais María Jose , Folgueira Dolores , Gude María José , Cueto Cecilia , Serrano Antonio , Lumbreras Carlos 
Published: January 2022

Abstract
BACKGROUND: Influenza viruses cause seasonal epidemics worldwide with a significant morbimortality burden. Clinical spectrum of Influenza is wide, being respiratory failure (RF) one of its most severe complications. This study aims to elaborate a clinical prediction rule of RF in hospitalized Influenza patients.METHODS: a prospective cohort study was conducted during two consecutive Influenza seasons (December 2016 - March 2017 and December 2017 - April 2018) including hospitalized adults with confirmed A or B Influenza infection. A prediction rule was derived using logistic regression and recursive partitioning, followed by internal cross-validation. External validation was performed on a retrospective cohort in a different hospital between December 2018 - May 2019. RESULTS: Overall, 707 patients were included in the derivation cohort and 285 in the validation cohort. RF rate was 6.8% and 11.6%, respectively. Chronic obstructive pulmonary disease, immunosuppression, radiological abnormalities, respiratory rate, lymphopenia, lactate dehydrogenase and C-reactive protein at admission were associated with RF. A four category-grouped seven point-score was derived including radiological abnormalities, lymphopenia, respiratory rate and lactate dehydrogenase. Final model area under the curve was 0.796 (0.714-0.877) in the derivation cohort and 0.773 (0.687-0.859) in the validation cohort (p<0.001 in both cases). The predicted model showed an adequate fit with the observed results (Fisher’s test p>0.43). CONCLUSION: we present a simple, discriminating, well-calibrated rule for an early prediction of the development of RF in hospitalized Influenza patients, with proper performance in an external validation cohort. This tool can be helpful in patient´s stratification during seasonal Influenza epidemics.
The Independent Association Between Age and Serum Cholesterol Levels in Patients with Familial Hypercholesterolemia
Authors: He Jinchun , Wang Yaodong , Zhang Yanpei , He Zhijie 
Published: January 2022

Abstract
(1) Background: Studies have suggested that age and the serum total cholesterol (TC) concentration are independent risk factors for cardiovascular disease (CVD) in patients with familial hypercholesterolemia (FH); however, the relationship between age and TC in patients with FH is unclear. We aimed to investigate the correlation between age and TC in patients with FH. (2) Methods: In this retrospective, controlled not matched analysis, a total of 103 patients with FH and 106 non-FH controls were recruited into the study from 2004 to 2017. Spearman and partial correlation analyses, as well as multiple regression analyses, were used to evaluate the relationship between TC and age. (3) Results: There were no significant differences in age, gender, or BMI between the FH group and the control group (p > 0.05). Family history of CVD, TC, low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), lipoprotein (a) (Lp(a)) and non-HDL-C levels were significantly higher in patients with FH compared to the control (p < 0.01). Additionally, the serum TC levels for ages ≥ 50 years were significantly higher than those for ages < 50 years (p < 0.05) in FH patients. In both Spearman and partial correlation analyses, age was found to be significantly correlated with serum TC (p < 0.001) in the FH group but not in the control group, which was confirmed by further multiple linear regression analyses and logistic regression analyses. (4) Conclusions: Age is an independent factor influencing serum TC level in patients with FH, and it is necessary to conduct early screening and early intervention.
RF-EMF Exposure Emitted From Mobile/cellular Phone and Risk of Glioma, Meningioma and Acoustic Neuroma: A Meta-analysis
Authors: Feng Yuxin , Zhou Zhiru , Fei Quanming , Wang Ying 
Published: January 2022

Abstract
IntroductionTo evaluate the association between mobile/cellular phone use and risk of three intracranial tumors (glioma, meningioma and acoustic neuroma) based on case-control studies through pooling the published data .MethodsWe conducted a systematic literature search in databases including PubMed, EMBASE, and the Cochrane Library up to September 2021. The primary outcome was the risk of tumors by mobile/cellular phone use, which was measured by pooling each odds ratio (OR) and its 95% confidence interval (CI). The random- or fixed-effects model was applied to combine the results depending on the heterogeneity of the analysis.ResultsWe ultimately included 6 articles for glioma, 6 articles for meningioma and 8 for acoustic neuroma from 1999 to 2015 . There was no significant association between mobile/cellular phone use and risk of glioma (OR, 0.98; 95% CI, 0.81-1.17; I²=76.9%, p=0.001) and acoustic neuroma (OR, 0.98; 95% CI, 0.76-1.25; I²=60.7%, p=0.013). And no statistical significance was observed between any subgroup of duration of use and these two type of cancer. Howerver, mobile phone use was associated with decrease the risk of meningioma, especially when the time since first use was between 0-5 years (OR, 0.83; 95% CI, 0.76-0.90; I²=39.5%, p=0.142) and 5-10 years (OR, 0.83; 95% CI, 0.75-0.93; I²=32.3%, p=0.194), while the protective effect disappeared in longer term (more than 10/11 years)(OR, 0.91; 95% CI, 0.80-1.03; I²=0.0%, p=0.870). ConclusionEvidence from our study mobile/cellular phone use may decreased risk of meningioma. Further studies are needed to explore the possible influence of long-term use of mobile phone and underlying mechanism.
Knowledge, attitude and practices of residences toward antimicrobial usage and resistance in Gondar, Northwest Ethiopia
Authors: Dejene Haileyesus , Birhanu Rediet , Tarekegn Zewdu Seyoum 
Published: January 2022

Abstract
Background

Antimicrobials are essential for human and animal health. Drug resistance to an antimicrobial agent follows the introduction of a new antimicrobial agent. Evidence suggests that the public plays an important role in the risk, increase, and spread of antimicrobial resistance. The purpose of this study was to assess the knowledge, attitudes, and practices of the Gondar city residences regarding antimicrobial use and resistance.
Methods

A cross-sectional study was conducted from April to July 2021 on 400 randomly selected Gondar city residents using a pretested semi-structured questionnaire. The descriptive and Chi-square tests were used to analyse the data.
Results

The response rate was one hundred percent. Approximately 75% of respondents were men, with 32% having completed secondary school. Nearly 74% and 35% of participants were married and worked in various government jobs, respectively. Furthermore, 48%, 54%, and 50% of respondents, respectively, had moderate knowledge, a positive attitude, and good practice concerning antimicrobial use and resistance. The chi-square analysis revealed a significant (p < 0.05) disparity between knowledge and educational level, marital status, and position in the house. The respondents' attitude level was also significantly associated (p < 0.05) with their educational level, marital status, occupation, and position in the house. Respondents' practice level was also significantly associated (p 0.05) with their educational level and occupation. The study also found a significant relationship between respondents' knowledge and attitude (χ2 = 215.23, p ≤ 0.001), knowledge and practice (χ2 = 147.2, p ≤ 0.001), and attitude and practice (χ2 = 116.03, p ≤ 0.001).
Conclusion

This study found that study participants had some misconceptions about antimicrobial use and resistance. As a result, enforcing antimicrobial regulation and educating people about antimicrobial use are both recommended.