bluuebunny/crossref_metadata_2025_split huggingface dataset:
Salesforce output control and customer-oriented selling behaviours
Authors: Amenuvor Fortune Edem , Basilisco Richard , Boateng Henry , Shin Kwan Soo , Im Dohyun , Owusu-Antwi Kwasi 
Published: February 2022

PurposeThis study sets out to empirically investigate the effect of salesforce output control on perceived job autonomy, customer-oriented selling behaviours and sales performance.Design/methodology/approachData are gathered from 704 salespeople and their visiting customers in Ghana. The hypotheses are tested using the structural equations modelling technique (SEM).FindingsAccording to the findings of the study, output control has a significant and positive impact on perceived job autonomy. It also discovers that perceived job autonomy improves both customer-directed problem solving and adaptive selling behaviours. Furthermore, the study finds that customer-directed problem solving and adaptive selling behaviours both improve sales performance. Moreover, the study uncovers that perceived job autonomy mediates the relationship between output control and customer-oriented selling behaviours, whereas both customer-oriented selling behaviours mediate the relationship between perceived job autonomy and sales performance.Practical implicationsThe current study provides both practical and theoretical insights into salesforce control dynamics, job autonomy, adaptive selling behaviour, customer-directed problem-solving behaviour and sales performance. The findings have important implications for sales organisations because they can assist sales managers in determining the best type of salesforce control systems to deploy and highlight the strategic role job autonomy plays in enhancing sales performance.Originality/valueThe current study shows how output control can influence salespeople's perceived job autonomy, adaptive selling and customer-directed problem-solving behaviours, and how these can improve sales performance.
How do parties react to defections? Electoral strategies after a valence loss
Authors: CERON ANDREA , VOLPI ELISA 
Published: February 2022

AbstractSwitches produce a lack of credibility and damage a party's image, signalling weakness and an inability to select loyal MPs and preserve unity. Accordingly, we consider party out‐switching as a valence loss for the party. By combining information on party manifestos with a novel database on 2053 episodes of party switching, we investigate which electoral strategies parties adopt to reduce the negative consequences of such valence loss. Analyzing 1,131 manifestos related to 135 parties in 14 Western European democracies, from 1945 to 2015, we show that parties try to restore their positive image by investing on valence, in terms of competence, clarity and core issues. An instrumental variable approach corroborates our results. The findings have implications for spatial modelling, valence politics, issue ownership and issue competition.
Cherry‐picking industrial properties in opportunity zones
Authors: Wiley Jonathan A. , Nguyen Hana 
Published: February 2022

AbstractWe examine the impact on industrial property prices following the launch of US opportunity zones—a location‐based tax incentive program intended to attract investment into low‐income communities. Using a national sample of commercial real estate transactions, we document significantly higher transaction premiums, when matched with comparable transactions in eligible tracts that were not included in the program. Consistent with development options that are incentivized by the program, we find that premiums are concentrated at properties with the largest amounts of excess land available, and we observe no evidence of spillover effects to properties that do not possess similar optionality. Among the designated opportunity zones, significant transaction premiums appear in areas that previously demonstrate high employment and population growth. Overall, we do not find evidence to suggest that the aggregate share of commercial real estate transaction volume to opportunity zones has increased following the legislation.
Anti‐obesity effects of Chenpi: an artificial gastrointestinal system study
Authors: Falduto Maria , Smedile Francesco , Zhang Man , Zheng Ting , Zhu Jieyu , Huang Qingrong , Weeks Richard , Ermakov Alexey M. , Chikindas Michael L. 
Published: February 2022

SummaryThe gut microbiota plays a significant role in human health; however, the complex relationship between gut microbial communities and host health is still to be thoroughly studied and understood. Microbes in the distal gut contribute to host health through the biosynthesis of vitamins and essential amino acids and the generation of important metabolic by‐products from dietary components that are left undigested by the small intestine. Aged citrus peel (Chenpi) is used in traditional Chinese medicine to lower cholesterol, promote weight loss and treat various gastrointestinal symptoms. This study investigated how the microbial community changes during treatment with Chenpi using the Simulator of the Human Intestinal Microbial Ecosystem (SHIME). Two preparations of Chenpi extract were tested: Chenpi suspended in oil only and Chenpi in a viscoelastic emulsion. Short‐chain fatty acids (SCFAs) were measured during treatment to monitor changes in the microbial community of the colon presenting a decrease in production for acetic, propionic and butyric acid (ANOVA (P < 0.001) during the 15 days of treatment. 16S rRNA sequencing of microbial samples showed a clear difference between the two treatments at the different sampling times (ANOSIM P < 0.003; ADOSIM P < 0.002 [R2 = 69%]). Beta diversity analysis by PcoA showed differences between the two Chenpi formulations for treatment day 6. These differences were no longer detectable as soon as the Chenpi treatment was stopped, showing a reversible effect of Chenpi on the human microbiome. 16S rRNA sequencing of microbial samples from the descending colon showed an increase in Firmicutes for the treatment with the viscoelastic emulsion. At the genus level, Roseburia, Blautia, Subdoligranulum and Eubacterium increased in numbers during the viscoelastic emulsion treatment. This study sheds light on the anti‐obesity effect of a polymethoxyflavone (PMFs)‐enriched Chenpi extract and creates a foundation for the identification of ‘obesity‐prevention’ biomarkers in the gut microbiota.
Aging alters the metabolic flux signature of the ER‐unfolded protein response in vivo in mice
Authors: Ward Catherine P. , Peng Lucy , Yuen Samuel , Halstead John , Palacios Hector , Nyangau Edna , Mohammed Hussein , Ziari Naveed , Dandan Mohamad , Frakes Ashley E. , Gildea Holly K. , Dillin Andrew , Hellerstein Marc K. 
Published: February 2022

AbstractAge is a risk factor for numerous diseases, including neurodegenerative diseases, cancers, and diabetes. Loss of protein homeostasis is a central hallmark of aging. Activation of the endoplasmic reticulum unfolded protein response (UPRER) includes changes in protein translation and membrane lipid synthesis. Using stable isotope labeling, a flux “signature” of the UPRER in vivo in mouse liver was developed by inducing ER stress with tunicamycin and measuring rates of both proteome‐wide translation and de novo lipogenesis. Several changes in protein synthesis across ontologies were noted with age, including a more dramatic suppression of translation under ER stress in aged mice as compared with young mice. Binding immunoglobulin protein (BiP) synthesis rates and mRNA levels were increased more in aged than young mice. De novo lipogenesis rates decreased under ER stress conditions in aged mice, including both triglyceride and phospholipid fractions. In young mice, a significant reduction was seen only in the triglyceride fraction. These data indicate that aged mice have an exaggerated metabolic flux response to ER stress, which may indicate that aging renders the UPRER less effective in resolving proteotoxic stress.
Idelalisib reduces regulatory T cells and activates T helper 17 cell differentiation in relapsed refractory patients with chronic lymphocytic leukaemia
Authors: Gadi Deepti , Griffith Alec , Wang Zixu , Tyekucheva Svitlana , Rai Vanessa , Fernandes Stacey M. , Machado John‐Hanson , Munugalavadla Veerendra , Lederer James , Brown Jennifer R. 
Published: February 2022

SummaryPhosphatidylinositol 3 kinase (PI3K) inhibitors such as idelalisib have been associated with potentially severe autoimmune toxicity. In the present study, we demonstrate that relapsed refractory patients with chronic lymphocytic leukaemia treated with idelalisib rituximab on the phase III registration trial show uniform decrease in regulatory T cells (Tregs) and increase in CD8 T cells with treatment. Patients who do not develop toxicity show enrichment for T cells expressing multiple chemokine receptors, while those who do develop toxicity have an activated CD8 T cell population with T helper 17 cell differentiation at baseline, which then increases, leading to an increased CD8:Treg ratio that likely triggers autoimmune toxicity.
Quantifying the prevalence of energy poverty across Canada: Estimating domestic energy burden using an expenditures approach
Authors: Das Runa R. , Martiskainen Mari , Li Grace 
Published: February 2022

AbstractEnergy poverty is gaining public attention in Canada. Based on statistical analysis of Statistics Canada's 2016 Survey of Household Spending, we estimate that 7–9% of households spent more than 10% of their income on energy expenditures. Households in the Atlantic provinces faced the most energy poverty and highest energy expenditures. Low income, geography, and dwelling conditions were the main predictors of energy poverty. Households in energy poverty also spent approximately five times more on energy expenditures as a proportion of their total expenditures compared to households not in energy poverty. Our study fills a key research gap as a limited number of studies exist on the extent and drivers of energy poverty in Canada. Further, our study's robust quantitative estimates allow benchmarking and comparative research. These estimates lay the groundwork for evidence‐based solutions—and our findings highlight the need to reconsider current policies. Considering the challenge of the ratio of energy costs to income is vital, especially in the aftermath of events such as COVID‐19 or the 2021 heatwave in western Canada, which result in different energy behaviours and needs. More broadly, in the regular day‐to‐day, energy services should be seen as necessary and decision makers ought to consider the energy burden of Canadians.
Multimodality imaging of Abernethy malformation
Authors: El‐Medany Ahmed Y. , Rego Gui , Williams Matthew , Lyen Stephen , Turner Mark 
Published: February 2022

AbstractAbernethy malformation, or congenital extrahepatic portosystemic venous shunt, is a rare anomaly involving the portal venous system. Despite its rarity, it is increasingly being reported, and therefore, it is important to diagnose given the potential adverse clinical consequences if left untreated. It has a spectrum of presentations, ranging from complete lack of symptoms, to causing hepatic carcinoma, hepatic encephalopathy, severe pulmonary hypertension, and diffuse pulmonary arteriovenous malformation. We herein describe the case and echocardiographic, computed tomography, and magnetic resonance imaging findings of a transgender individual, with this anomaly detected incidentally during adulthood.
Rib fractures in adult horses as a cause of poor performance; diagnosis, treatment and outcome in 73 horses
Authors: Hall Suzy , Smith Roger , Ramzan Peter H. L. , Head Marcus , Robinson Natalie , Parker Russell 
Published: February 2022

AbstractBackgroundRib fractures in adult horses are poorly documented.ObjectivesTo describe the presenting signs, diagnosis, treatment and outcome of horses diagnosed with rib fracture.Study designRetrospective case series.MethodThe clinical records and diagnostic images of all adult horses diagnosed with a rib fracture at three referral centres over a 15‐year period were reviewed.ResultsSeventy‐three horses met the inclusion criteria. Horses presented due to either resistance to ridden work and poor performance (n = 41), lameness (n = 21) or trauma (n = 7). In four horses, the presenting complaint was not recorded. Clinical assessment and palpation localised the site of injury in 18/47 cases where recorded. Nuclear scintigraphic examination identified all fracture sites in which it was performed (59/59). In 10/24 horses, radiographic examination confirmed rib fracture. Ultrasonographic examination confirmed rib fracture in 58/59 horses (98%; 95% CI 92‐100). Six horses underwent surgery due to ongoing clinical signs and non‐healing fracture; all other horses were managed conservatively. Fifty‐five horses were available for long‐term follow up (>1 year), of which 28 (51%; 95% CI 38‐64) returned to their previous level of exercise. Twelve horses did not return to their previous level of exercise due to lameness unrelated to the rib fracture and seven horses were subjected to euthanasia, of which three were as a result of the rib fracture. Eight horses did not return to their previous level of exercise for other reasons.Main limitationsIncomplete data set due to retrospective case series.ConclusionsAlthough uncommon, rib fractures should be considered in cases of reduced performance or resistance during ridden exercise. Palpation may be unrewarding. Scintigraphy and ultrasonography are useful in identifying the fracture site. Rib fractures in horses carry a fair prognosis and can be managed conservatively in most cases.
Global benefits of non‐continuous flooding to reduce greenhouse gases and irrigation water use without rice yield penalty
Authors: Bo Yan , Jägermeyr Jonas , Yin Zun , Jiang Yu , Xu Junzeng , Liang Hao , Zhou Feng 
Published: February 2022

AbstractNon‐continuous flooding is an effective practice for reducing greenhouse gas (GHG) emissions and irrigation water use (IRR) in rice fields. However, advancing global implementation is hampered by the lack of comprehensive understanding of GHGs and IRR reduction benefits without compromising rice yield. Here, we present the largest observational data set for such effects as of yet. By using Random Forest regression models based on 636 field trials at 105 globally georeferenced sites, we identified the key drivers of effects of non‐continuous flooding practices and mapped maximum GHGs or IRR reduction benefits under optimal non‐continuous flooding strategies. The results show that variation in effects of non‐continuous flooding practices are primarily explained by the UnFlooded days Ratio (UFR, that is the ratio of the number of days without standing water in the field to total days of the growing period). Non‐continuous flooding practices could be feasible to be adopted in 76% of global rice harvested areas. This would reduce the global warming potential (GWP) of CH4 and N2O combined from rice production by 47% or the total GWP by 7% and alleviate IRR by 25%, while maintaining yield levels. The identified UFR targets far exceed currently observed levels particularly in South and Southeast Asia, suggesting large opportunities for climate mitigation and water use conservation, associated with the rigorous implementation of non‐continuous flooding practices in global rice cultivation.
Game‐based, gamified, and gamefully designed assessments for employee selection: Definitions, distinctions, design, and validation
Authors: Landers Richard N. , Sanchez Diana R. 
Published: February 2022

AbstractReflecting practitioner efforts to improve existing psychometric assessments, a new games‐related class of assessments and assessment design approaches has emerged, and research is beginning to examine it as well. Understanding this class of assessments requires understanding of three major terms. First,game‐based assessmentrefers to an assessment method in which job candidates are players participating in a core gameplay loop while trait information is inferred. Second,gameful designrefers to practices by assessment professionals using game mechanics or other game concepts to guide their decision‐making in assessment design. Third,gamificationrefers to practices by assessment professionals changing existing assessments by adding game mechanics and applying game concepts to them. Whereas game‐based assessment is itself an assessment method, the other two are (re)design strategies. In this review, we explore these distinctions in finer terms, describe the game design and development processes necessary to create a functional game‐based assessment, describe theoretical and practical concerns related to the use or addition of game mechanics in traditional assessment methods, and present evaluation guidelines for the entire assessment class. Overall, we conclude that the future of games‐related assessment is promising, but further progress will require a focus on interdisciplinary understanding and much greater integration of design and development into assessment theory.
Increase in heart rate‐dependent left atrial pressure is associated with symptoms in patients with paroxysmal atrial fibrillation
Authors: Fukuhara Eiji , Mine Takanao , Kishima Hideyuki , Kitagaki Ryo , Ishihara Masaharu 
Published: February 2022

AbstractBackgroundIt remains unclear why some patients with the same heart rate during an atrial fibrillation (AF) have subjective symptoms, whereas others do not. We assessed the hypothesis that different responses of arterial and left atrial blood pressures to rapid stimulation may be associated with the symptoms of AF.MethodsA total of 110 patients who underwent catheter ablation for paroxysmal AF were retrospectively studied. Asymptomatic AF was defined as a European Heart Rhythm Association score of Ⅰ for AF‐related symptoms. The left atrial pressure (LAP) was measured during sinus rhythm (SR), in 10 pacing per minute (ppm) increments from 100 ppm to the Wenckebach block rate in high right atrial pacing.ResultsAsymptomatic AF was observed in 19/110 patients (17%). Patients with symptomatic AF showed higher E/e′ ratio and gradual LAP increase that was dependent on the pacing rate. Patients with asymptomatic AF had decreased LAP at 100 ppm compared that at SR, and thereafter, LAP gradually increased depending on the pacing rate. The rate of LAP change compared to that at SR was significantly lower in patients with asymptomatic AF than that in patients with symptomatic AF. The rate of LAP change was independently associated with AF symptoms.ConclusionPatients with asymptomatic AF showed lower E/e′ ratio and decreased LAP at 100 ppm to rapid stimulation, followed by a steady increase in LAP afterwards. Factors other than left ventricular diastolic dysfunction may be involved in AF symptoms.
TRASS: a global approach to assess the severity of truncal acne
Authors: Auffret N. , Nguyen J.M. , Leccia M.‐T. , Claudel J.P. , Dréno B. 
Published: February 2022

AbstractIntroductionOnly a small amount of published data regarding truncal acne is available, and no proper tool to assess its severity exists.AimThe aim of the study was to provide dermatologists with an easy‐to‐use tool to assess truncal acne (TRASS, truncal acne severity scale) using a global approach.MethodsA scoring tool that assesses the severity of acne (based on GEA and ECLA scales) on the trunk using a global approach was built, including three sub‐scores: family history, clinical signs and quality of life (QoL). In order to test TRASS, the experts used photographs of 47 patients attending their clinics with truncal acne. The regression optimized (ROP) model was applied to assess the diagnosis performance of TRASS and to identify items contributing to the classification of the patients. Internal testing was made to demonstrate the robustness of the model. Correlation analyses between the different items were performed to evaluate the interaction between the different items and their impact on the severity grading of truncal acne.ResultsPatients with the most severe acne were identified by TRASS. The error level was 6.6% after internal validation and 10.4% when using the median value or the centile 75th (6.6% and 10.4%). Correlation was significant between systemic treatment and scars (P = 0.0025) and nodules (P = 0.01988) and between location and QoL (P = 0.0095).ConclusionTruncal acne severity scale is the first global, patient‐centred approach to evaluate truncal acne by scoring the importance of each factor independently from its clinical severity. TRASS may allow the practitioner to choose and validate the most suitable therapy together with the patient in order to treat his or her truncal acne successfully and to limit treatment failure.
Genetic diversity of Aedes albopictus (Skuse) in Sarawak, Malaysia and other regions of the world
Authors: Lau Koon Weng , Low Van Lun , Chen Chee Dhang , Sofian‐Azirun Mohd 
Published: February 2022

AbstractThis study inferred the genetic diversity and dispersal pattern of Aedes albopictus, for the first time from various populations in Sarawak, the largest Malaysian state situated in northwest Borneo Island. A set of sequences of 120 Ae. albopictus from Sarawak aligned as 633 characters of the cytochrome c oxidase subunit I (COI) revealed 22 haplotypes (A1–A22), of which A1 was the most widespread haplotype. The overall haplotype and nucleotide diversities were 0.65014 and 0.00176, respectively, with no significant genetic differentiation and high gene flow (Nm = 1.07). The genetic distances among the populations ranged from 0 to 0.0227. In the global dataset, sequence alignment of Ae. albopictus from Sarawak and other regions of the world revealed 72 haplotypes. Based on uniquely shared haplotypes, Ae. albopictus in Sarawak has a close affinity with those from Southeast Asian and Oceania regions.