bluuebunny/crossref_metadata_2025_split huggingface dataset:
Acute coronary syndrome after liver transplantation in a young primary biliary cholangitis recipient with dyslipidemia: a case report
Authors: Yao Siyuan , Iwashita Akiho , Yagi Shintaro , Watanabe Hirotoshi , Nishio Takahiro , Koyama Yukinori , Nagai Kazuyuki , Kamo Naoko , Taura Kojiro , Hatano Etsuro 
Published: June 2022

AbstractBackgroundPrimary biliary cholangitis (PBC) is a chronic, progressive liver disease associated with dyslipidemia. There is a consensus that PBC does not accelerate coronary artery disease despite high cholesterol levels, so the screening test for the coronary artery is not routinely performed before liver transplantation (LT). To date, no report has described the potential risk of PBC-related dyslipidemia for developing acute coronary syndrome (ACS) after LT.Case presentationA 40-year-old Asian female with a known history of PBC underwent ABO-incompatible living-donor LT, with her husband as the donor. Although she had high cholesterol and triglyceride levels that were refractory to medications, she passed all routine preoperative examinations, including cardiopulmonary function tests and infection screenings. One week after LT, she developed ACS with 90% stenosis of both the left anterior descending artery and left circumflex artery. Emergent stent implantation was successfully performed followed by dual antiplatelet therapy. The long history of PBC and associated severe dyslipidemia for 10 years would have accelerated the atherosclerosis, causing latent stenosis in the coronary artery. Inapparent stenosis might have become apparent due to unstable hemodynamics during the acute phase after LT.ConclusionsPBC-related dyslipidemia potentially brings a risk for developing ACS after LT. This experience suggests that the preoperative evaluation of the coronary artery should be considered for high-risk patients, especially those who have drug-resistant dyslipidemia.
Twinkling-guided ultrasound detection of polymethyl methacrylate as a potential breast biopsy marker: a comparative investigation
Authors: Lee Christine U. , Urban Matthew W. , Lee Miller A. , Uthamaraj Susheil , Jakub James W. , Hesley Gina K. , Wood Benjamin G. , Brinkman Nathan J. , Herrick James L. , Larson Nicholas B. , Yaszemski Michael J. , Greenleaf James F. 
Published: June 2022

AbstractSince its first description 25 years ago, color Doppler twinkling has been a compelling ultrasound feature in diagnosing urinary stones. While the fundamental cause of twinkling remains elusive, the distinctive twinkling signature is diagnostically valuable in clinical practice. It can be inferred that if an entity twinkles, it empirically has certain physical features. This work investigates a manipulable polymeric material, polymethyl methacrylate (PMMA), which twinkles and has measurable surface roughness and porosity that likely contribute to twinkling. Comparative investigation of these structural properties and of the twinkling signatures of breast biopsy markers made from PMMA and selected commercially available markers showed how twinkling can improve ultrasound detection of devices intentionally designed to twinkle. While this specific application of detecting breast biopsy markers by twinkling may provide a way to approach an unmet need in the care of patients with breast cancer, this work ultimately provides a platform from which the keys to unlocking the fundamental physics of twinkling can be rigorously explored.
Comparative study Of TVS cervical score and Bishop score in prediction of successful labour induction
Authors: Agrawal Alka , Tripathi P. S. , Bhandari Gaurav , Kheti Pramita , Madhpuriya Gulshan , Rathore Roshani 
Published: June 2022

Abstract
Background
In today's obstetric practice, induction of labour is a common procedure. Before the imaging era, the favourability of the cervix was assessed by manual examination scored as the Bishop Score. However, subjectivity and high inter- and intra-observer variability are limitations of this approach. This necessitates the implementation of an objective method of assessment. We used transvaginal sonography (TVS) as an objective method of assessment of cervix by TVS cervical score comprising of five different parameters; cervical length, funnelling at the internal os, distance from the presenting part to the external os, and cervix position. This study aims to evaluate the role of the pre-induction transvaginal ultrasonographic (TVS) cervical score in predicting labour outcome and comparing it to the Bishop score in patients undergoing induction of labour.

Methodology
This observational prospective study included 100 pregnant women admitted for labour induction at a single tertiary care centre. The TVS examination which consisted of five parameters was performed after the clinical Bishop scoring. The TVS scores were compared with the Bishop scores for all patients. Labour induction was done within one hour of examination and the outcome of the induction was recorded.

Results
The mean age was 25.87 years [SD = 4.35]. Labour induction was successful in 74% of patients. At cut-off Scores of ≥ 4, TVS cervical Score performed better than Bishop Score (Sensitivity 93.24 vs. 67.57%, Specificity 73.08 vs. 65.38%). ROC analysis indicated that Area Under Curve (AUC) was more for TVS Score (0.91, 95% CI 0.84–0.97), compared to Bishop Score.

Conclusion
Transvaginal ultrasonography is an objective method of cervical assessment. We conclude from our study that the use of TVS score which consists of five different parameters in cervical assessment provides a better prediction of successful labour induction than the Bishop score, and so can prevent various complications associated with induction failure.
The role of triphasic CT imaging and 18F FDG PET CT on detection of extrahepatic metastases and proper staging of HCC: a comparative study
Authors: Barakat Mai M. K. , Badran Ethar M. , Allam Yasmine Emad Aldin Hassan , Alsabbagh Zenat Ahmed , Abdelrahman Ahmed S. 
Published: June 2022

Abstract
Background
Extrahepatic metastases and proper staging of HCC are mandatory for proper assessment of the disease process and its exact extent. Subsequently, clinicians can put precise management and treatment strategies for patients with metastatic HCC. 18FFDG PET/CT is one of the best imaging modalities for the proper detection of metastases and staging. It can provide both functional information and high contrast resolution of CT.

Results
On comparison between 18F FDG PET/CT and triphasic CT regarding metastases PET/CT showed greater sensitivity (92.3%) and specificity (84.4%), than triphasic CT (51.3%), (81/3%), and (76.9%), respectively. PET/CT revealed that the SUV max cutoff point for diagnosis of HCC was > 3.PET/CT revealed an SUV max cutoff point of > 5.57 for predicting that HCC has extrahepatic metastases. PET/CT revealed an SUV max cutoff point of > 3.35 for differentiating between metastatic and nonmetastatic lesions.

Conclusions
PET/CT combines the advantages of the excellent functional information provided by PET and the contrast resolution of CT. It increases the rate of detection of extrahepatic metastases, so it is more sensitive than triphasic CT in the staging of HCC. Using the standard uptake value proved to be efficient in HCC diagnosis and staging being more related to the functional activity of the tumor cells.
Strategic Parent Meets Detached Child? Parental Intended Bequest Division and Support From Children
Authors: Ho Christine 
Published: June 2022

Abstract
While the literature shows that elderly parents may use bequests to reward children who provide them with time support, there is limited evidence on whether younger, less needy parents base their intended bequest division on alternative forms of support from children. This study uses data from the June 2018 Singapore Life Panel and focuses on a sample of 4,125 adult children and their middle-aged and older parents. From family fixed-effects estimation, I find that parents intend to leave larger bequest shares to coresident children and to children who provide greater material support. Parents also intend to bequeath more to children in whom they confide frequently, while children in whom they confide rarely receive more bequests only if they provide greater material support. The results suggest that parents may interpret physical and emotional proximity to children as signs of filiality for which they may reward them, while detached children may earn such rewards through material support. This study demonstrates the existence of coresidence-for-bequest and money-for-bequest exchanges between adult children and their middle-aged and older parents. These exchanges may translate into future caregiving-for-bequests when parents become elderly, and may thus have broader implications for both individual and societal well-being.
More
Authors: Owen Ianna Hawkins 
Published: June 2022

Abstract
In response to the widely circulated asexual provocation “Why have sex when there is cake?” this essay explores the productive overlap between asexuality's nonsexual pleasures associated with food and feedism's sexual pleasures associated with eating. Building on a long-standing interest in Audre Lorde's interventions concerning erotic pleasure, “More” theorizes “quantity” as an antihierarchical queer framework for perceiving, thinking, and holding such experiences. Toward this end, the essay closely reads an asexual pride poster, a painting by Wayne Thiebaud, and a photograph by Nayland Blake.
Glucocorticoids enhance chemotherapy-driven stress granule assembly and impair granule dynamics, leading to cell death
Authors: Schwed-Gross Avital , Hamiel Hila , Faber Gabriel P. , Angel Mor , Ben-Yishay Rakefet , Benichou Jennifer I. C. , Ishay-Ronen Dana , Shav-Tal Yaron 
Published: June 2022

ABSTRACT
Stress granules (SGs) can assemble in cancer cells upon chemotoxic stress. Glucocorticoids function during stress responses and are administered with chemotherapies. The roles of glucocorticoids in SG assembly and disassembly pathways are unknown. We examined whether combining glucocorticoids such as cortisone with chemotherapies from the vinca alkaloid family, which dismantle the microtubule network, affects SG assembly and disassembly pathways and influences cell viability in cancer cells and human-derived organoids. Cortisone augmented SG formation when combined with vinorelbine (VRB). Live-cell imaging showed that cortisone increased SG assembly rates but reduced SG clearance rates after stress, by increasing protein residence times within the SGs. Mechanistically, VRB and cortisone signaled through the integrated stress response mediated by eIF2α (also known as EIF2S1), yet induced different kinases, with cortisone activating the GCN2 kinase (also known as EIF2AK4). Cortisone increased VRB-induced cell death and reduced the population of cells trapped in mitotic catastrophe. These effects were mediated by the core SG proteins G3BP1 and G3BP2. In conclusion, glucocorticoids induce SG assembly and cell death when administered with chemotherapies, suggesting that combining glucocorticoids with chemotherapies can enhance cancer cell chemosensitivity.
Imaging findings of lower limb involvement following COVID-19
Authors: Godoy Ivan Rodrigues Barros , Rodrigues Tatiane Cantarelli , Zamariolli Gabriela dos Santos , Dias Gustavo Pimenta de Figueiredo , Yamada André Fukunishi , Skaf Abdalla Youssef 
Published: June 2022

Coronavirus disease 2019 (COVID-19) is known mainly by the severe acute respiratory syndrome, with myalgia as a common clinical symptom. Recent reports described musculoskeletal complications related to COVID-19 such as myositis, neuropathy and arthropathy. Radiologists and ordering physicians should be aware of lower limb complications following severe COVID-19 for optimal patient care.
New Cycles and Systemic Crises of the World Economy
Authors: Basovskaya Elena , Basovskiy Leonid 
Published: June 2022

The purpose of the work was to identify new long-term cycles of modern world economic dynamics. In the world economic dynamics, long-term - half-century cycles were identified, identified as the cycles of N. Kondratiev, which were formed during the formation of the industrial economy. The transition to a post-industrial economy could change the cyclic nature of economic dynamics. To assess possible changes in the system of long-term cycles of economic dynamics, a spectral analysis of the series of per capita GDP of the leaders of the world economy in terms of labor productivity was performed. The results showed that in the 20th century the economic dynamics of Great Britain and the United States formed powerful cycles with a period of 25-30 years. A spectral analysis of the series of per capita GDP in the world for the period 1962-2019 has been performed. The results obtained indicate that at the turn of the 20th-21st centuries, powerful cycles with a period of 25-30 years were formed in world economic dynamics, significantly exceeding half-century cycles in terms of power.
Econometric models with a cyclic (harmonic) component are constructed to estimate the parameters of cycles. At the first stage of research, the model of world per capita GDP was guarded, the optimized period of which was 65. At the second stage, a model was built, the optimized period of which was 25 years. The possibility of the existence of two models indicates that in the economic systems of developed countries, in the world economy, transitional processes are taking place. Both models may reflect the beginning of the formation at the beginning of the second decade of a new technological order, characteristic of the post-industrial economic system. This means the possibility of a systemic global economic crisis in 2022-2023.
Actual Problems of Financial Planning of Income, Expenses and Coverage of the State Budget Deficit in the Subject of the Federation on the Materials of the Tula Region
Authors: Yarovova V. , Tarasova I. 
Published: June 2022

The article discusses the theoretical and practical tasks of planning revenues and expenditures in the regional budget. The dynamics and structure of the financial resources on the example of the Tula region for a number of years are analyzed from the perspective of budget consolidation. The impact of regional budget finances on the investment opportunities of the regional budget and the distribution of gross product in a crisis is considered. Based on the actual material, the role assigned to regional budget finances in achieving benchmarks for socio-economic development is revealed. The problems of repayment of the budget deficitt of the subject of the federation and possible ways to solve them are identified. The problems of the budget process are identified and directions for further improvement of the policy of financing public expenditures and diversification of sources of covering the regional budget deficit are proposed.
The representativeness of the actual data and the author's calculation and forecast estimates is achieved on the basis of the use of general scientific and special research methods, such as analysis and synthesis, comparison, detailing, dialectical, balance and normative methods; elements of systematic and integrated approaches to finding solutions.
The practical significance of the study is determined by the all-Russian attitude to strengthening budgetary federalism, motivating the regions of Russia in the direction of reducing the level of subsidization into revenue part of the budget of the region, reducing its deficit, increasing the share of its own sources of covering all planned budget allocations.
Assessing the effectiveness of learning a complex motor activity in children aged 9-10 years
Authors: Matczak Dawid , Wieczorek Marta 
Published: June 2022

Introduction
Learning is a complex and multi-dimensional process that depends on cognitive and emotional processes and the development of functional systems of the human body. One type of learning is motor learning. Its course and effects depend on many factors, one of the factors may be gender. Differences between intellectual and motor learning tend to be blurred when learning a complex motor activity takes place.
Purpose
The cognitive aim of the study is to assess the effectiveness (speed, efficiency, durability) of learning a complex motor activity in a selected group of girls and boys.
Materials and methods:
The study was conducted among 73 children (44 boys and 29 girls) aged 9 - 10 years. The teaching experiment method consisting of three stages was used. The research tool is a program of learning to juggle with three tennis balls. Learning speed was assessed using the Learning Speed Rate (LSR); efficiency was based on the results of subsequent stages as part of the experiment, whereas durability was evaluated on the basis of the effect compliance between stages of the experiment.
Results:
The speed, efficiency and durability of learning a complex motor activity in children participating in the study showed similar levels. Slow learning was dominant among both girls and boys. Yet, boys achieved better learning effects than girls, but these differences were not statistically significant. The subjects showed high durability of learning effects.
Conclusions:
The effectiveness of learning a complex motor activity is characterized by inter-subject variability. Gender makes distinction in terms of speed, efficiency and durability of learning a complex motor activity.
Inverse lithography source and mask optimization via Bayesian compressive sensing
Authors: Sun Yiyu , Li Yanqiu , Liu Lihui 
Published: June 2022

Source and mask optimization (SMO) is a key technique to guarantee the lithographic fidelity for 14-5 nm technology nodes. The balance between lithography fidelity and computational efficiency is a big issue for SMO. Our earlier works of compressive sensing SMO (CS-SMO) effectively accelerated the SMO procedure by sampling monitoring pixels. However, the imaging fidelity of the results of these methods can be further improved. This paper proposes a novel Bayesian compressive sensing source and mask optimization (BCS-SMO) method, to the best of our knowledge, to achieve the goals of fast SMO and high fidelity patterns simultaneously. The SMO procedure can be achieved by solving as a series of re-weighted

l
1

-norm reconstruction problems, and the weights can be updated in every iteration. The results demonstrate that, with similar computational efficiency, the BCS-SMO method can significantly improve lithographic fidelity over the current CS-SMO method.
Effect of methylprednisolone treatment on COVID-19: An inverse probability of treatment weighting analysis
Authors: Porta Lorenzo , Huang Sih-Shiang , Wei Chen , Su Chin-Hua , Hsu Wan-Ting , Sheng Wang-Huei , Lee Chien-Chang 
Published: June 2022

Objectives
While corticosteroids have been hypothesized to exert protective benefits in patients infected with SARS-CoV-2, data remain mixed. This study sought to investigate the outcomes of methylprednisone administration in an Italian cohort of hospitalized patients with confirmed SARS-CoV-2 infection.

Methods
Patients with confirmatory testing for SARS-CoV-2 were retrospectively enrolled from a tertiary university hospital in Milan, Italy from March 1st to April 30th, 2020 and divided into two groups by administration of corticosteroids. Methylprednisolone was administered to patients not responding to pharmacological therapy and ventilatory support at 0.5-1mg/kg/day for 4 to 7 days. Inverse probability of treatment weighting (IPTW) was used to adjust for baseline differences between the steroid and non-steroid cohorts via inverse probability of treatment weight. Primary outcomes included acute respiratory failure (ARF), shock, and 30-day mortality among surviving patients.

Results
Among 311 patients enrolled, 71 patients received steroids and 240 did not receive steroids. The mean age was 63.1 years, 35.4% were female, and hypertension, diabetes, heart disease, and chronic pulmonary disease were present in 3.5%, 1.3%, 14.8% and 12.2% respectively. Crude analysis revealed no statistically significant reduction in the incidence of 30-day mortality (36,6% vs 21,7%; OR, 2.09; 95% CI, 1.18–3.70; p = 0.011), shock (2.8% vs 4.6%; OR, 0.60; 95% CI = 0.13–2.79; p = 0.514) or ARF (12.7% vs 15%; OR, 0.82; 95% CI = 0.38–1.80; p = 0.625) between the steroid and non-steroid groups. After IPTW analysis, the steroid-group had lower incidence of shock (0.9% vs 4.1%; OR, 0.21; 95% CI,0.06–0.77; p = 0.010), ARF (6.6% vs 16.0%; OR, 0.37; 95% CI, 0.22–0.64; p<0.001) and 30-day mortality (20.3% vs 22.8%; OR 0.86; 95% CI, 0.59–1.26 p = 0.436); even though, for the latter no statistical significance was reached. Steroid use was also associated with increased length of hospital stay both in crude and IPTW analyses. Subgroup analysis revealed that patients with cardiovascular comorbidities or chronic lung diseases were more likely to be steroid responsive. No significant survival benefit was seen after steroid treatment.

Conclusions
Physicians should avoid routine methylprednisolone use in SARS-CoV-2 patients, since it does not reduce 30-day mortality. However, they must consider its use for severe patients with cardiovascular or respiratory comorbidities in order to reduce the incidence of either shock or acute respiratory failure.
Sexual health behavior, health status, and knowledge among queer womxn and trans men in Kenya: An online cross-sectional study
Authors: Haase Stephanie , Müller Alex , Zweigenthal Virginia 
Published: June 2022

Introduction
Little research has been conducted on the sexual health needs and risk behaviors of queer womxn and trans men, making it difficult to identify specific health needs and disparities. This is especially the case in the Global South, where their needs are poorly understood. This study presents findings on demographics, sources of information, sexual (risk) behaviors, and substance use in Kenyan queer womxn and trans men.

Methods
An online survey among 335 Kenyan queer womxn and trans men was used to collect data on sexual health, risk behavior, health information sources, and substance use. The participants needed to have had at least one self-identified female sexual partner.

Results
The sample presented young, highly-educated queer womxn and trans men. A high incidence of childhood sexual trauma found was found. Risk behaviors included sexual activities with partners of multiple genders, violence, and low use of barrier methods. One in three participants had been treated for an STD in the previous year. The incidences of smoking and drinking were high, and a quarter of participants indicated having taken drugs at least once a month or more. The internet was either the first or second most important source of sexual health information for 44.1% of the participants, followed by schools (30.9%).

Discussion and conclusion
Our findings indicate that queer womxn and trans men are at risk of negative sexual health outcomes due to a lack of appropriate information, risk behavior, substance use, and low uptake of sexual health services. Kenya’s Penal Code still criminalizes consensual same-sex activities and may play a role in perpetuating barriers that prohibit them from making healthier choices. Developing tailored programming and policies require local, national, and global stakeholders to engage with the inclusion of queer womxn and trans men’s sexual health needs within strategic planning and healthcare delivery.