bluuebunny/crossref_metadata_2025_split huggingface dataset:
Chemometric model for rapid detection of urea and hydrogen peroxide in milk
Authors: Basak M , Uddin MN , Jahan RA , Rana AA , Karim MM 
Published: June 2022

A simple and cost effective method has been developed for determination of adulteration in milk with urea and hydrogen peroxide by using chemometric modeling with Fourier Transform Infrared (FTIR) spectroscopic data. Milk samples were purchased from a dairy farm (South Banasree, Dhaka, Bangladesh) and spiked at different concentrations of urea and hydrogen peroxide. Spectral data of all samples were collected using ATR-FTIR spectrophotometer. After acquisition of spectral data, they were preprocessed with transformation techniques such as multiplicative scatter correction (MSC) and savitzky-golay derivative. The predictive performance of principal component regression (PCR) and partial least-square regression (PLSR) methods were assessed by relative prediction errors and recoveries (%) were compared . PLSR shows better prediction efficiencies over PCR with R2 value 99% for urea and 95% for hydrogen peroxide.Six brands of commercial milk samples have been evaluated by this method and the samples contain 21.66-44.73 mg urea and 1.62-2.86 mg hydrogen peroxide in 100 ml milk. This method can be easily used in the quality assessment of milk.
Bangladesh J. Sci. Ind. Res.56(1), 1-8, 2021
In vitro regeneration of Mirabilis jalapa L.
Authors: Rahman MS , Nandi NC , Goswami B 
Published: June 2022

In vitro regeneration of Mirabilis jalapa L., an important medicinal plant, has been successfully established from nodal explants. Maximum numbers of shoots (8.1) were obtained using Murashige and Skoog (MS) medium containing BAP (3.0 mg/l). Next to the highest response by nodal explants of M. jalapa was shown on MS medium supplemented with 2.0 mg/l BAP +1.0 mg/l IAA + 1.0 mg/l Kn. In it, the mean value of shoot number was 7.3. The highest frequency of root induction (80%) were obtained on MS medium supplemented with IAA (0.5 mg/l) and 40 ml/l coconut water. The rooted plantlets were transferred for hardening following acclimatization and finally were successfully planted in the field.
Bangladesh J. Sci. Ind. Res.56(1), 25-28, 2021
Clinical Spectrum and Management of Ovarian Masses in Children and Adolescent up to 20 Years of Age
Authors: Khatoon Farhana , Begum Shirin Akter , Choudhury Nazneen , Yeasmin Sabiha , Begum Monowara 
Published: June 2022

Pathological type as well as management of ovarian tumor in the pediatric population are different than adult women. We performed a retrospective analysis of clinical and diagnostic aspects of ovarian tumors and tumor-like lesions in girls in order to identify characteristics associated with malignancy and it’s clinical management which is different from adult women. This is a descriptive type of cross sectional study was condunted among seventy nine female children and adolescent admitted in Bangabandhu Sheikh Mujib Medical University (BSMMU) with ovarian mass from January 2017 to December 2020. Secondary data were collected from hospital record review. The demographic data, diagnostic procedure, management and histopathological analysis of the ovarian tumor were recorded. Mean age of study population was 16.7±3.1 and age range was 8-20 Years. Benign and malignant ovarian tumor was 40.50% and 59.49% respectively. The main symptom and sign were abdominal pain and palpable mass were found in 51% and 50% cases respectively. Malignant lesion appeared as cystic in 22.44%, solid 44.89% and mixed in 32.65% cases. But benign ovarian tumor was found predominantly as cystic in 70% cases preoperatively. More than three fourth (75.51%) of malignant ovarian tumor showed one or more positive tumor marker whereas one third (33.33%) benign tumor had raised tumor marker. Large lesions in both benign and malignant cases were found in almost similar number of cases and these were 80% and 81% respectively. In the group of solid tumors, positive tumor marker results occurred more frequently in patients with malignant tumor (57.14%). Elevated serum alpha feto protein (AFP), Human Chorionic Gonadotrophin (HCG) and high Lactate Dehydrogenage (LDH) value associated more often with malignant tumor. Laparotomy was performed in all cases of study population. Among 49 malignant ovarian tumour 34 (69.3%) underwent ovary preserving surgery. All patient with benign ovarian tumor undergone conservative surgery. Predominantly solid structures noted on imaging studies, large dimension and positive tumor markers are clinical predictors of malignancy. Multicenter prospective studies are needed to improve and unify the ovarian preservation rates across the world.
Bangladesh Med J. 2021 January; 50(1) : 1-9
Radionuclide Renogram Findings in Different Kidney Diseases Referred to Institute of Nuclear Medicine and Allied Science (INMAS)
Authors: Zahid Bhuiyan Mohammed Mehedi Al , Nahar Kamrun , Mia Md Azzad , Hossain Arshad , Tasnim Humayra , Islam Md Saiful 
Published: June 2022

Renal function evaluation with the use of radio nuclide scanning is a very helpful technique. Renogram is a routine procedure in the Institute of Nuclear Medicine and Allied Sciences (INMAS), Sylhet. This is a tertiary referral hospital to north east part of the country. The aim of this study was to analyze the renal disease pattern and outcome of diuretic renogram of different types of renal diseases. This retrospective study was conducted among 223 patients who underwent 99mTc-DTPA renogram from February to October 2018 in INMAS, Sylhet. Mean age of the patients was 30.04 ± 18.52 year with age range 1 to 80 years, male to female ratio 1.5:1. USG. Clinical information and other adjuvant findings along with the ultrasound findings were collected to categorize the study subject. Most common indication for the renogram was hydronephrosis (HDN) 80.27%, followed by smaller kidney 7.17%, renal parenchymal disease 3.14%, nephrolithiasis 3.14% and others (renal cysts and renal artery stenosis). The mean and standard deviation of serum creatinine was 0.9 ± 0.51, range from 0.30 to 4.50. Among the 179 HDN patients, mild, moderate and severe cases were 37 (20.7%), 44 (24.6%) and 81 (45.3%) respectively. Most common site of involvement was left kidney (n=90, 41.3%), followed by both kidneys (n=67, 30.7%). Overall renographic findings showed obstructive disease in 144 (66.05%) patients and non- obstructive disease in 74 (33.94%) patients. It concluded that isotope renogram is very important in the evaluation of renal function especially differentiate between obstructive from non-obstructive pathology.
Bangladesh Med J. 2021 January; 50(1) : 10-14
Clinicopathological Profile of Head and Neck Cancer Patients in a University Hospital, Bangladesh
Authors: Talukdhar Sajib Kumar , Alam Sarwar , Bari Md Abdul , Sharmin Sadia , Shams Mohammad Jahan , David Arnob Barua 
Published: June 2022

In Bangladesh, the head and neck cancer is one of the most prevalent cancers. The goal of this study was to assess at the clinicopathological characteristics of individuals with head and neck cancer. This descriptive, cross-sectional study was conducted from July to December 2018, 286 patients with head and neck cancer were included at Bangabandhu Sheikh Mujib Medical University (BSMMU), Department of Clinical Oncology. A pre-made questionnaire was used to collect data from patients during face-to-face interviews. The mean age of the patients was 56.27 (±12.23) years. The bulk of the cases (77.6%) were male, and the most of the patients consumed tobacco (86%). The most common histological type among the patients was squamous cell carcinoma (92%). In terms of primary tumor location, the oral cavity (36%) was the most prevalent. Patients were most often found in stages III (32.2%) and IV (34.6%). In conclusion, head and neck cancer occurs mainly in males and tobacco users. Squamous cell carcinoma is the most frequent histological form, with the oral cavity as the main location of tumors. The majority of the patients are in advanced stages.
Bangladesh Med J. 2021 January; 50(1) : 23-26
Relation of Serum Uric Acid Concentrations with Etiology and Severity in Patients with Cirrhosis of Liver
Authors: Hasan Rashedul , Kumar Roy Projesh , Rahman Khan Md Masudur , Ahmed Farid , Alam Md Razibul , Gain Gobinda 
Published: June 2022

Hyperuricaemia is now an established factor to cause oxidative stress, insulin resistance and systemic inflammation. So it is likely that hyperuricemia might be involved in hepatic necroinflammation and destruction which are the common underlying pathophysiology of cirrhosis. On the other hand, as uric acid is the end product of cellular degradation, increased hepatocyte destruction due to any etiology increases the level of serum uric acid which might further aggravate hepatic necroinflammation, cirrhosis and complications. The aim of this study is to assess serum uric acid concentrations in patients of cirrhosis of liver and its relation with cirrhosis of different etiology, disease severity and liver enzymes. This cross sectional observational study was carried out in the Department of Gastroenterology, Banghabandhu Sheikh Mujib Medical University, Bangladesh during the period of September 2015 to October 2016. A total of 220 diagnosed cases of cirrhosis of liver due to any cause from inpatient and outpatient Department of Gastroenterology were enrolled as the study population. Serum uric acid level was measured in each patient and its relationship with different etiology of cirrhosis, severity of cirrhosis and liver enzymes were assessed. The mean age was found to be 47.8 ± 14.6 years and male: female ratio was 1.9:1. Majority patients (52.3%) belonged to Child-Turcotte-Pugh Class C. The mean (±SD) value of serum uric acid was 6.19 (±3.25mg/dl) and hyperuricemia (>7 mg/dl) was detected in 27.73% patients. Among all etiologies of cirrhosis, the higher mean (±SD) level of serum uric acid was found in Non-alcoholic Fatty Liver Disease (19.54 ±2.20 mg/dl). There was positive correlation of serum uric acid with liver enzymes. Mean serum uric acid level increased gradually as the cirrhotic patients progressed to higher CTP classes and there was positive correlation of serum uric acid with liver enzymes. It requires further large scale multicenter studies with increased sample size & prolong follow-up to establish serum uric acid as a risk factor of cirrhosis of liver.
Bangladesh Med J. 2021 January; 50(1) : 46-51
Outcome of Neonatal Acute Kidney Injury in a Special Care Baby Unit (SCABU)
Authors: Ferdaus Tahmina , Afroz Shireen , Mollah Md Abid Hossian , Banerjee Manisha , Khan Tofazzal Hossain 
Published: June 2022

Background: Acute kidney injury (AKI) is common in neonates admitted in Special Care Baby Unit (SCABU) with high morbidity and mortality.
Objective: The present study was intended to see the immediate hospital outcome of neonatal acute kidney injury (AKI) in a Special Care Baby Unit (SCABU).
Methods: This observational study was carried out in SCABU, in the Department of Paediatrics, Dhaka Medical College Hospital, from October 2013 to March 2014. A total of 44 neonates (from 3-28 days) with AKI were included in this study. AKI staging was done by using pediatric RIFLE criteria as Risk, Injury, Failure. Patients were managed conservatively and immediate hospital outcome was assessed by SCABU stay, multiorgan failure, resolution of AKI, mortality and dialysis as needed.
Results: Demographic profile among the study population the neonate of d”7 days old comprised the main bulk. Majority of the neonates were of average birth weight. The diagnosis was based on estimated creatinine clearance(eCCL) criteria of pRIFLE showed that 40.9% neonates were at risk of AKI, 20.5% have had already injured. Higher proportions of neonates were classified as failure (38.6%).Outcome variables of neonatal AKI predicted by pRIFLE criteria was significantly higher in failure group in respect to SCABU stay (12.1+ 7.9) p value < 0.001, multiorgan failure (41.2 %) p value 0.026 and dialysis needed (88.2 %) p value < 0.001, resolution from AKI (47.1%) p value 0.885, Mortality (41.2%) p value 0.106. Here 43% neonates with AKI were improved with normal renal function and 29% improved with impaired renal function. Increased frequency of death (28%) in this series was due to multiorgan involvement and significantly higher in failure group with adequate dialysis support.
Conclusion: From the findings of the study it can be concluded that immediate hospital outcome of neonatal AKI is worst even after adequate dialysis support. Multiorgan involvements, increase length of hospital stay at SCABU, increase need for dialysis, are the important cause of increase mortality and morbidity. So, early detection, prompt referral and immediate supportive therapy could improve the outcome of neonatal AKI.
DS (Child) H J 2018; 34(1) : 5-10
Guillain-Barré Syndrome: Outcome of Treatment by IVIG vs. Methylprednisolone in Pediatric Intensive Care Unit of a Tertiary Care Hospital
Authors: Hoque Md Shafiul , Masud Mohammed Akter Hossan , Ahmed ASM Nawshad Uddin 
Published: June 2022

Background: Guillain-Barré Syndrome (GBS) deserves a serious attention in children. The treatment of GBS consists of supportive and immune-modulator treatments, among which intravenous immunoglobulin (IVIG) is considered as most effective. But IVIG is costly and many patients cannot afford.
Objective: To document the outcome of treatment of GBS patients by IVIG and Methylprednisolone.
Methods: This is a retrospective study conducted in the Pediatric intensive care unit of Dhaka Shishu Hospital from January 2013 to December 2016. Data was collected from the admission record file in pediatric intensive care unit of Dhaka Shishu Hospital. A total of 36 patients up to the age of 15 years presenting with Guillain-Barré Syndrome were included in the study. Treatment modalities including supportive, Intravenous Immunoglobulins (IVIG) and steroids were selected in patients with GBS depending upon indication and facilities available. Those who were unable to provide IVIG due to financial constrain were treated with Methylprednisolone. Results were analyzed using SPSS (version 16) for Windows.
Results: During the study period, a total of 36 patients were diagnosed and treated as GBS in pediatric intensive care unit. Among those, 34 (94.4%) patient were classical GBS. Most patients were in the age range of 3-5 years (21, 58.3%). Total 19 (52.8%) patients were treated with IVIG and rest was treated with steroid (17, 47.2%). 16 (44.4%) patient needed mechanical ventilation and among the patient needed mechanical ventilation 9 (56.3%) got treatment with IVIG and 7 (43.7%) got treatment with Methylprednisolone. After treatment 31 (86.2%) patients were improved and 5 (13.8%) were expired. Among the improved patient 16 (84.2%) were treated with IVIG and 15 (88.2%) were treated with Methylprednisolone.
Conclusion: Treatment outcome of GBS patient with Methylprednisolone is comparable with IVIG and can be considered in case of financial constrain.
DS (Child) H J 2018; 34(1) : 30-35
Clinical Pattern of Pediatric Tuberculosis in a Tertiary Care Hospital in Bangladesh
Authors: Ahsan Mohammed Rizwanul , Hussain Manzoor , Makbul Sabrina , Sarkar Probir Kumar , Al Mamun ABM Mahfuj Hasan 
Published: June 2022

Background: Pediatric tuberculosis (TB) contribute a significant proportion of the TB burden in Bangladesh yet little is known about the clinical characteristics of this childhood TB which remains unclear.
Objectives: This study of paediatric TB is designed to evaluate the clinical profile of childhood TB to determine the various clinical presentation of various type of childhood TB among the patients admitted in Dhaka Shishu(Children) Hospital.
Methods: This is a cross-sectional retrospective study, we reviewed all case file of TB patients from January to June 2018 in the Division of Pediatrics medicine of Dhaka Shishu (Children) Hospital, Dhaka, Bangladesh.
Results: Among 51cases of tuberculosis most cases presented in the age between 1 to 5 years 21(41.18%), 7(13.73%) were within 1 year, 17(33.33%) were 6 to 10 years, 6(11.76%) were above 10 years of age. Most of them were male 27(52.94%) and 24(47.06%) were female. Maximum cases presented with symptoms of Fever 48(94.12%), Cough (84.31%), Vomiting 25(49.02%), Cold 36(70.59%), abdominal pain (18.8%), Breathlessness 12(23.53%), Convulsion 6(11.76%), lymphadenopathy 5 (16.13%), Swelling 4(7.84%) and Skin lesion 1(1.96%). Finally among all Tuberculosis cases most of them were Pulmonary TB 32(62.76%) and other forms of TB were abdominal TB 6(11.76%), CNS TB 5(9.80%), TB lymphadenitis 3(5.88%), miliary TB 2(3.92%), Disseminated TB 2(3.92%) and Tubercular abscess 1(1.96%).
Conclusion: In this study pulmonary tuberculosis patients are more commonly found than extra-pulmonary tuberculosis in pediatric age group.
DS (Child) H J 2019; 35(1) : 9-13
Correlation of Acid-Base Status with Mortality of Neonates Admitted in PICU
Authors: Hoque Md Shafiul , Sarkar Prabir Kumar 
Published: June 2022

Background: The human organs and tissues function under a tightly controlled pH in the range of 7.35 to7.45. Depending on the degree of deviation of pH outside this narrow range, several homeostatic responses are activated in an effort to restore normal acid-base status.
Objectives: To study the acid-base disturbances in neonates admitted in PICU.
Methods: This study was conducted in Pediatric Intensive Care Unit (PICU) of Dhaka Shishu (Children) Hospital for a period of six monthsfrom January to June 2018. Hundred neonates attending pediatric emergency services with various ailments were curolled. Arterial blood gas (ABG) analysis was estimated in these neonates. Ethical committee approval was taken. Results: Metabolic acidosis was the most common acid-base disorder. Fifty-seven neonates had metabolic acidosis.Significant correlation was observed between metabolic acidosis and pathological conditions like birth asphyxia and sepsis.
Conclusion: Metabolic acidosis is the most common acid base disorder in critically ill neonates.In this study it was the most common cause of mortality. If we do earlyintervention in correction of acid-base abnormality, the outcome is likely to get improved in neonates.
DS (Child) H J 2019; 35(1) : 37-41
Sociodemographic Profile and Comorbidities of Children with Epilepsy Attending in Child Development Centre (CDC) of Dhaka Shishu Hospital
Authors: Quaderi Humaira Rafiqa , Sharker Shaoli , Kanta Shayla Imam , Mahbub Mustafa 
Published: June 2022

Background: Epilepsy is the most common conditions encountered in most paediatric neurology clinics in many parts of the developing world. It is important to understand the sociodemographic profile of children with epilepsy and also to recognize the comorbidities associated with themfor planning management and developing wider services within the country.
Objectives: The present study aimed at understanding the socio-demographic profileand comorbidities of children with epilepsy, seeking treatment at a tertiary care hospital in Bangladesh.
Methods: This retrospective observational study was conducted in an epilepsy clinic of Paediatric Neuroscience Department of Dhaka Shishu Hospital (DSH) over a period of 3 years from January 2013 to December 2015. During this period 1 year follow up record of each patient was analysed. Information on biodemographic data, clinical and developmental assesment made by a multidysciplinary team was analysed.
Results: A total 120 children who had epilepsy were included in this study.The median age at presentation was 2.4 years. Male were 69(58%) and female were 51(42%). Most of the children came from rural area (58%, n=70). Middle income families were over presented (58%). 82% had a history of perinatal asphyxia. Motor, speech impairment and malnutrition were found more who had H/O perinatal asphyxia (P value 0.002,0.005 and 0.03 respectively.
Conclusion:In conclusion, epilepsy is one of the commonest neurological morbidity in our environment. This study has provided important information about sociodemographic profile and associated comorbidities in children with epilepsy. This information can be used as a guideline for developing services for children with epilepsy and in prevention of some detectable causes in our countries like birth asphyxia which is found large number in this study.
DS (Child) H J 2019; 35(1) : 48-54
Antibiotic Resistance among Enteric Fever Pathogens in a Tertiary Care Children Hospital of Bangladesh
Authors: Rahman Md Mizanur , Bhuiyan AKM Tajuddin 
Published: June 2022

Background: Enteric fever, a public health problem endemic in Bangladesh involves multiple systems. Fluoroquinolones and third generation cephalosporins are first line drugs used in treatment, which has led to increased minimal inhibitory concentration (MIC) of ciprofloxacin causing therapeutic failure. In recent years using these drug some treatment failure found.
Objectives: To study the antibiotic resistance among enteric fever pathogens in young children and to study the isolation rate of S. typhi and S. paratyphi among different age groups of children.
Methods: A prospective study was done in Pediatric Infectious & Community Pediatrics Department of Dhaka shishu (Children) Hospital among admitted children age 1 to 15 years from January 2018 to January 2019. During this period 62 blood culture samples with growth of S.typhi & S.paratyphi were processed. The antibiotic susceptibility was done by modified Kirby disk diffusion.
Results: During this 1 year from 72 admission days, 216 suspected enteric fever children admitted in Pediatric Infectious & Community Pediatric Department. Out of these 216 patients, isolation rate of enteric fever pathogens by blood cultures was 62 (28.7%). Majority of the isolates were S. typhi (75.8%) and S. paratyphi A were 24.2%. Among them 40(64.5%) isolates were from 5 to 15 years of age. Antibiotic resistance pattern was Ampicillin 37.1%, Chloramphenicol 30.64%, Co-trimoxazole 35.48%, Ceftriaxone (0%), Azithromycin (19.35%), resistance or reduced susceptibility to Ciprofloxacin was found in 77.41%, Nalidixic acid 100%, ten isolates (16.12%) were MDR. The most susceptible antibiotic was ceftriaxone while most resistant was nalidixic acid.
Conclusion: The increasing numbers of enteric fever pathogens with decreasing susceptibility to ciprofloxacin and azithromycin is a concern. Increasing dependency to ceftriaxone and cefixime may cause resistance to these drugs near future. So, we can choose older drugs again in some cases.
DS (Child) H J 2019; 35(1) : 55-58
Efficacy of Methylprednisolone and Lignocaine on Propofol Injection Pain in Pediatric Surgical Patients: A Randomized Clinical Trial
Authors: Islam Md Jahirul , Jahan Ismat 
Published: June 2022

Background: Mild to severe pain or discomfort on injection of propofol used for the induction of anaesthesia is often observed in pediatric population.
Objectives: This study was designed to compare the efficacy of methylprednisolone and lignocaine in reducing the pain of propofol injection in patients scheduled for pediatric surgery.
Methods: Total 135 children scheduled for elective surgery were divided into three groups: saline (group S, n=45), lignocaine 20 mg (Group L, n=45) and methylprednisolone 125 mg diluted into 2 ml of distilled water (Group MP, n=45). Drugs were administered after tourniquet application and occlusion was released after 1 min and 25% of the total dose of propofol (2 mg/kg) was administered at the rate of 0.5 ml/s. Pain on propofol injection was evaluated by four-point verbal rating scale. Data were analyzed by using SPSS version 21.
Results: The overall incidence of pain was 65.9% in the saline group, 23.8% in the lignocaine group and 30.5% in the methylprednisolone group. Intensity of pain was significantly less in patients receiving methylprednisolone and lignocaine than those receiving saline (p< 0.05).
Conclusion: Pre-treatment with intravenous methylprednisolone was found to be as effective as lignocaine in reducing propofol injection-induced pain.
DS (Child) H J 2019; 35(1) : 59-62