bluuebunny/crossref_metadata_2025_split huggingface dataset:
Time of Day and High-Stake Cognitive Assessments
Authors: Gaggero Alessio , Tommasi Denni 
Published: December 2022

Abstract
A variety of external conditions may affect individual performance in high-stake cognitive assessments, with potentially lasting consequences on earnings and career. We provide the first causal evidence that the time of the day is an important condition affecting the performance at the moment of an evaluation. Exploiting a setting in which cognitive assessments are quasi-randomly assigned at a different time of day, we find that peak performance occurs in the early afternoon. The estimated time-of-day effects follow specific patterns consistent with the circadian rhythm, which suggests that biological factors are important determinants of performance even in economically meaningful settings.
The impact of influenza vaccination on cardiovascular diseases
Authors: Carro Amelia 
Published: December 2022

AbstractThe link between influenza and medical complications is well stablished and plays a role in the high mortality rates of this disease. Available scientific evidence suggests that influenza vaccination might reduce the risk of cardiovascular events. This setting for cardiovascular prevention beyond immunoprotection has been studied in several clinical trials. Most of them include populations with coronary artery disease. However, differences in clinical design, population included, and vaccination strategies might explain divergent results and should be interpreted with caution. The present article summarizes available literature in a manner that aids physicians in a better interpretation and encourages the implementation of influenza vaccination in cardiovascular prevention programmes.
EASY-WPW: a novel ECG-algorithm for easy and reliable localization of manifest accessory pathways in children and adults
Authors: El Hamriti Mustapha , Braun Martin , Molatta Stephan , Imnadze Guram , Khalaph Moneeb , Lucas Philipp , Nolting Julia Kathinka , Isgandarova Khuraman , Sciacca Vanessa , Fink Thomas , Bergau Leonard , Sohns Christian , Kiuchi Kunihiko , Nishimori Makoto , Heeger Christian-Hendrik , Borlich Martin , Shin Dong-In , Busch Sonia , Guckel Denise , Sommer Philipp 
Published: December 2022

AbstractAimsAccessory pathway (AP) ablation is a standard procedure for the treatment of Wolff-Parkinson-White syndrome (WPW). Twelve-lead electrocardiogram (ECG)-based delta wave analysis is essential for predicting ablation sites. Previous algorithms have shown to be complex, time-consuming, and unprecise. We aimed to retrospectively develop and prospectively validate a new, simple ECG-based algorithm considering the patients’ heart axis allowing for exact localization of APs in patients undergoing ablation for WPW.Methods and resultsOur multicentre study included 211 patients undergoing ablation of a single manifest AP due to WPW between 2013 and 2021. The algorithm was developed retrospectively and validated prospectively by comparing its efficacy to two established ones (Pambrun and Arruda). All patients (32 ± 19 years old, 47% female) underwent successful pathway ablation. Prediction of AP-localization was correct in 197 patients (93%) (sensitivity 92%, specificity 99%, PPV 96%, and NPV 99%). Our algorithm was particularly useful in correctly localizing antero-septal/-lateral (sensitivity and specificity 100%) and posteroseptal (sensitivity 98%, specificity 92%) AP in proximity to the tricuspid valve. The accuracy of EASY-WPW was superior compared to the Pambrun (93% vs. 84%, P = 0.003*) and the Arruda algorithm (94% vs. 75%, P &lt; 0.001*). A subgroup analysis of children (n = 58, 12 ± 4 years old, 55% female) revealed superiority to the Arruda algorithm (P &lt; 0.001*). The reproducibility of our algorithm was excellent (ϰ&gt;0.8; P &lt; 0.001*).ConclusionThe novel EASY-WPW algorithm provides reliable and accurate pre-interventional ablation site determination in WPW patients. Only two steps are necessary to locate left-sided AP, and three steps to determine right-sided AP.
Three-dimensional electroanatomical mapping guided right bundle branch pacing in congenitally corrected transposition of great arteries
Authors: Namboodiri Narayanan , Kakarla Saikiran , Mohanan Nair Krishna Kumar , Abhilash Sreevilasam P , Saravanan Sabari , Pandey Harsh Kumar , Vijay Jyothi , Sasikumar Deepa , Valaparambil Ajit Kumar 
Published: December 2022

AbstractAimsThe ideal pacing strategy has been the Achilles’ heel for patients with congenitally corrected transposition of great arteries (ccTGA) with bradycardia. Various pacing modalities were documented in the literature. This article describes a novel pacing strategy and its feasibility in ccTGA with an intact ventricular septum.Methods and resultsWe prospectively recruited three patients with ccTGA who presented with symptomatic complete heart block to our institute and were evaluated. All patients were planned for conduction system pacing. Those who had more than moderate or severe systemic atrioventricular regurgitation and systemic ventricular dysfunction were planned for conduction system pacing with an additional lead in the coronary sinus (CS) tributary, i.e. bundle branch pacing optimized cardiac resynchronization therapy with the intention to achieve incremental benefit. Since right bundle pacing is not described previously and in view of anatomical complexity in location, three-dimensional (3D) anatomical mapping was done with the EnSite system and later right bundle capture is identified conventionally as that of a left bundle in a normal heart. All three patients have stable lead positions and adequate thresholds at short-term follow-up.ConclusionIn this report, we demonstrated the feasibility of permanent physiological pacing of the systemic ventricle by capturing the right bundle with 3D anatomical mapping guidance, which results in physiological activation of the systemic ventricle.
Particle-associated bacteria in seawater dominate the colony-forming microbiome on ZoBell marine agar
Authors: Heins Anneke , Harder Jens 
Published: December 2022

Abstract
Planktonic particle-associated bacteria comprise particle-attached and motile free-living cells. These groups were obtained by settlement in Imhoff cones. Dilution plating on marine agar 2216 (ZoBell marine agar) and microscopic counts indicated a cultivability of 0.7% (0.4%–1.2%) of bacteria in coastal seawater collected at Helgoland Roads, North Sea. Particle-associated bacteria presented a minority population in seawater, but had a larger cultivability of 25% (0.9%–100%) for populations collected by settlement of particles and 5.7% (0.9%–24%) for populations collected by filtration. Partial 16S rRNA gene sequences indicated that 84% of the cultured taxa were either enriched in particle-associated microbiomes or only found in these microbiomes, including Sulfitobacter and other Rhodobacteraceae, Pseudoalteromonas, Psychromonas, Arcobacter and many Flavobacteriaceae. Illumina-based 16S rRNA V3V4 amplicon sequences of plate communities revealed that nearly all operational taxonomic units had a cultivated and described strain in close phylogenetic proximity. This suggested that decades of strain isolation from seawater on ZoBell marine agar had achieved a very good coverage of cultivable genera abundant in nature. The majority belonged to particle-associated bacteria, complementing observations that abundant free-living seawater bacteria often require cultivation conditions closer to their natural habitat like liquid cultivation in oligotrophic medium.
A cytotoxic triterpenoid from a Periplaneta americana-derived, Gordonia hongkongensis WA12-1-1
Authors: Wang Jie , He Mengying , Zeng Huanxiong , Liu Wenbin , Luo Xiongming , Ma Yan , Chen Zhiyu , Jin Xiaobao 
Published: December 2022

Abstract
The secondary metabolites produced by microorganisms are a source of novel compounds with antitumor activities. In this study, we isolated biologically active secondary metabolites produced by microorganisms in the intestinal tract of Periplaneta americana. Based on the 16S rRNA gene sequencing, Gordonia hongkongensis WA12-1-1 was identified as the main microorganisms in the intestinal tract of P. americana. The obtained sequence was deposited in the National Center for Biotechnology Information (NCBI) database under the accession number MZ348554. The isolated secondary metabolites were separated and purified by thin layer chromatography, silica gel column chromatography, Sephadex column chromatography, open octadecyl silane column chromatography, high-performance liquid chromatography (HPLC), and semipreparative HPLC. Next, the structure of individual compounds was determined by ultraviolet spectroscopy, nuclear magnetic resonance, and mass spectrometry. A total of 20 compounds were isolated from the secondary metabolites produced by G. hongkongensis WA12-1-1. A total of 12 compounds were obtained from the crude ethyl acetate extract of the culture supernatant and eight from the cellular fraction. Compound 1 was identified as a triterpenoid named gordonterpene and showed cytotoxicity against A549 and HepG2 cell lines. These findings form a basis for further studies on the bioactivity of gordonterpene to tumor cells.
Numt Parser: Automated identification and removal of nuclear mitochondrial pseudogenes (numts) for accurate mitochondrial genome reconstruction in Panthera
Authors: de Flamingh Alida , Rivera-Colón Angel G , Gnoske Tom P , Kerbis Peterhans Julian C , Catchen Julian , Malhi Ripan S , Roca Alfred L 
Published: December 2022

Abstract
Nuclear mitochondrial pseudogenes (numts) may hinder the reconstruction of mtDNA genomes and affect the reliability of mtDNA datasets for phylogenetic and population genetic comparisons. Here, we present the program Numt Parser, which allows for the identification of DNA sequences that likely originate from numt pseudogene DNA. Sequencing reads are classified as originating from either numt or true cytoplasmic mitochondrial (cymt) DNA by direct comparison against cymt and numt reference sequences. Classified reads can then be parsed into cymt or numt datasets. We tested this program using whole genome shotgun-sequenced data from 2 ancient Cape lions (Panthera leo), because mtDNA is often the marker of choice for ancient DNA studies and the genus Panthera is known to have numt pseudogenes. Numt Parser decreased sequence disagreements that were likely due to numt pseudogene contamination and equalized read coverage across the mitogenome by removing reads that likely originated from numts. We compared the efficacy of Numt Parser to 2 other bioinformatic approaches that can be used to account for numt contamination. We found that Numt Parser outperformed approaches that rely only on read alignment or Basic Local Alignment Search Tool (BLAST) properties, and was effective at identifying sequences that likely originated from numts while having minimal impacts on the recovery of cymt reads. Numt Parser therefore improves the reconstruction of true mitogenomes, allowing for more accurate and robust biological inferences.
Vegetation community dynamics during naturalized developmental restoration ofPinus tabulaeformisplantation in North warm temperate zone
Authors: Qiu Zhenlu , Zhang Mei , Wang Kefan , Shi Fuchen 
Published: December 2022

AbstractThe study is to explore the dynamics of community structure, diversity, interspecific relationships and stability during naturalized developmental vegetation restoration which realized by natural interaction between plantation and native trees without human’s involvement. The naturalized developmental restored forests in Baxianshan National Reserve were divided into three typical stages (i.e. Pinus tabulaeformis forest stage, mixed forest stage and near-natural forest stage) according to the ratio of P. tabulaeformis coverage to arbor layer, and the zonal natural secondary forests for control. According to the data of each wood gauge, we focused on the dynamics of community in terms of structure, diversity and stability. We found that, (i) The composition of dominant populations kept stable since the mixed forests stage and the α-diversity increased with restoration; (ii) The diameter class structure of tree layer exhibited a tendency of bell-shaped type toward inverted J-type, indicating an active regenerating and developmental status; (iii) Niche width of dominant populations such as Juglans mandshurica, Quercus mongolica, Quercus variabilis and Tilia amurensis increased during restoration, while that of Quercus dentata population decreased after playing a pioneer role; (iv) The proportion of negative association and high niche overlapped population pairs (&gt;0.5) both decreased with restoration. In summary, naturalized developmental restoration has promoted the actively developing and regenerating of populations and improved the healthy restoration of plantation community. The status and interrelationships of populations were still being adjusted. The results provide a reference for revealing the dynamic characteristics of vegetation community development in naturalized developmental restoration of plantations.
Review of meteorite irradiation tests to support next C-type asteroid missions
Authors: Kereszturi Á , Gyollai I , Juhász Z , Pál B D , Rácz R , Rezes D , Sulik B 
Published: December 2022

ABSTRACT
Effect of space weathering of airless asteroids could be better understood by artificial irradiation tests on meteorites in laboratories. This work surveys the infrared and Raman analysis based interpretation of simulated charged particle irradiation tests in order to better understand near-future observational possibilities of asteroid visiting missions and also to support the planning of next missions and directions of detector improvement. Recent works properly targeted different meteors and meteor relevant minerals, evaluating bulk meteorite spectra, during the irradiation tests. He+, (Ne+, Kr+), and Ar+ ions were used with fluxes characteristic for inner planetary system solar wind, considering 1–10 million yr exposure durations. Although main meteorite minerals were irradiated and analysed, one missing aspect is that only bulk analysis have been done, not minerals separately in their original embedded context. Some Earth based mineral references were also analysed; however, they might not necessarily behave similar to the same type of reference minerals and irradiation effect is poorly known for feldspar, troilite, and magnetite. Darkening should be also further analysed for separate minerals too, together with the record of peak shape and position changes. Infrared ATR analysis might still provide such data in the future using the recently emerged technology, as well as Raman analysis – however for flyby missions’ infrared is the useful method while Raman can be used only at in situ missions. The overview including the tables to support the identification of specific missing information related gaps in our current knowledge and directions for future research.
Quantifying the dust in SN 2012aw and iPTF14hls with ORBYTS
Authors: Niculescu-Duvaz Maria , Barlow M J , Dunn William , Bevan Antonia , Ahmed Omar , Arkless David , Barker Jon , Bartolotta Sidney , Brockway Liam , Browne Daniel , Esmail Ubaid , Garner Max , Guz Wiktoria , King Scarlett , Kose Hayri , Lampstaes-Capes Madeline , Magen Joseph , Morrison Nicole , Oo Kyaw , Paik Balvinder , Primrose Joanne , Quick Danny , Radeka Anais , Rodney Anthony , Sandeman Eleanor , Sheikh Fawad , Stansfield Camron , Symister Delayne , Taylor Joshua , Wilshere William , Wesson R , De Looze I , Clayton G C , Krafton K , Matsuura M 
Published: December 2022

ABSTRACTCore-collapse supernovae (CCSNe) are capable of producing large quantities of dust, with strong evidence that ejecta dust masses can grow significantly over extended periods of time. Red–blue asymmetries in the broad emission lines of CCSNe can be modelled using the Monte Carlo radiative transfer code damocles, to determine ejecta dust masses. To facilitate easier use of damocles, we present a Tkinter graphical user interface (GUI) running damocles. The GUI was tested by high school students through the Original Research By Young Twinkle Students programme, who used it to measure the dust masses formed at two epochs in Type IIP CCSNe, SN 2012aw and iPTF14hls, demonstrating that a wide range of people can contribute to scientific advancement. Bayesian methods quantified uncertainties on our model parameters. From the red scattering wing in the day 1863 Hα profile of SN 2012aw, we constrained the dust composition to large (radius &gt;0.1 μm) silicate grains, with a dust mass of $6.0^{+21.9}_{-3.6}\times 10^{-4}~\mathrm{ M}_\odot$. From the day 1158 Hα profile of SN 2012aw, we found a dust mass of $3.0^{+14}_{-2.5}\times 10^{-4}$ M⊙. For iPTF14hls, we found a day 1170 dust mass of 8.1$^{+81}_{-7.6}\times 10^{-5}$ M⊙ for a dust composition consisting of 50 per cent amorphous carbon and 50 per cent astronomical silicate. At 1000 d post-explosion, SN 2012aw and iPTF14hls have formed less dust than the peculiar Type II SN 1987A, suggesting that SN 1987A may have formed a larger dust mass than typical Type IIP’s.
Total electron content depression in the nightside Martian ionosphere: statistical results from Mars Express MARSIS measurements and implications
Authors: Cao Yutian , Niu Dandan , Liang Wenjun , Cui Jun , Wu Xiaoshu , Wan Xin , Zhong Jiahao , Li Lei , Rong Zhaojin , Wei Yong 
Published: December 2022

ABSTRACT
Thermal electron depression and energetic electron depletion are two well-known features of the nightside Martian ionosphere. While the latter has been extensively studied in the past, there is no report of systematic and firm identification of the former and hence the correlation between them is unknown. Applying an automatic procedure to the Mars Express total electron content (TEC) measurements, we identify a large number of TEC depression features that amount to one-third of the available nightside measurements. Similar to the observation of energetic electron depletion, large amplitude TEC depression is more frequently observed near strong magnetic fields, as an expected result of the established solar-wind-driven scenario that the shielding of precipitating electrons by closed magnetic loops is responsible for the observed reduction in thermal electron density. However, small amplitude depression appears to be uniformly distributed across the Martian surface, implying an alternative origin yet to be determined. Contrary to our expectation, TEC depression and energetic electron depletion are not usually collocated, but this dilemma may simply reflect the complexity of the magnetic field topology with respect to the spacecraft trajectory.
Assessing university policies for enhancing societal impact of academic research: A multicriteria mapping approach
Authors: Kuipers-Dirven Rosa , Janssen Matthijs , Hoekman Jarno 
Published: December 2022

Abstract
While there is a prolific debate on evaluating the societal impact of academic research, so far little attention has been paid to assessing the design and implementation of suitable organizational strategies. This article argues that evaluation methods are needed which are both formative and sensitive to diverging views on what defines and constitutes societal impact. We use a participatory deliberation method, the Multicriteria Mapping (MCM) approach, to examine how stakeholders appraise the use of university policy options for enhancing societal impact, and understand on what basis they judge the performance of these options. Focusing on a large Dutch research-based university, we conduct 22 interviews with academics, management, and support staff as well as strategic policy officers to examine how they rank and discuss the expected performance of university policy options identified in previous literature. Our results show that interviewees base their scores on criteria related to policy options’ expected organizational output and external outcomes, as well as their practical and, to a lesser degree, cultural, and financial feasibility. The resulting rankings also point at contrasts in the perceived potential of policy options, with interviewees assigning priority to providing researchers with recognition and rewards for impact-based activities. We conclude by discussing how MCM can be used as a formative evaluation method to assess and select policies and inform decision-making that fit a university’s particular situation. Besides drawing lessons for the context of our illustrative case, we also reflect on the relevance of the evaluation method and our findings for other universities.
Power of Bayesian and Heuristic Tests to Detect Cross-Species Introgression with Reference to Gene Flow in the Tamias quadrivittatus Group of North American Chipmunks
Authors: Ji Jiayi , Jackson Donavan J , Leaché Adam D , Yang Ziheng 
Published: December 2022

Abstract
In the past two decades, genomic data have been widely used to detect historical gene flow between species in a variety of plants and animals. The Tamias quadrivittatus group of North America chipmunks, which originated through a series of rapid speciation events, are known to undergo massive amounts of mitochondrial introgression. Yet in a recent analysis of targeted nuclear loci from the group, no evidence for cross-species introgression was detected, indicating widespread cytonuclear discordance. The study used the heuristic method HYDE to detect gene flow, which may suffer from low power. Here we use the Bayesian method implemented in the program BPP to re-analyze these data. We develop a Bayesian test of introgression, calculating the Bayes factor via the Savage-Dickey density ratio using the Markov chain Monte Carlo (MCMC) sample under the model of introgression. We take a stepwise approach to constructing an introgression model by adding introgression events onto a well-supported binary species tree. The analysis detected robust evidence for multiple ancient introgression events affecting the nuclear genome, with introgression probabilities reaching 63%. We estimate population parameters and highlight the fact that species divergence times may be seriously underestimated if ancient cross-species gene flow is ignored in the analysis. We examine the assumptions and performance of HYDE and demonstrate that it lacks power if gene flow occurs between sister lineages or if the mode of gene flow does not match the assumed hybrid-speciation model with symmetrical population sizes. Our analyses highlight the power of likelihood-based inference of cross-species gene flow using genomic sequence data. [Bayesian test; BPP; chipmunks; introgression; MSci; multispecies coalescent; Savage-Dickey density ratio.]