bluuebunny/crossref_metadata_2025_split huggingface dataset:
Automation Assemblages in the Internet of Things: Discovering Qualitative Practices at the Boundaries of Quantitative Change
Authors: Novak Thomas P , Hoffman Donna L 
Published: April 2022

Abstract
We examine consumers’ interactions with smart objects using a novel mixed-method approach, guided by assemblage theory, to discover the emergence of automation practices. We use a unique text data set from the web service IFTTT, (“If This Then That”), representing hundreds of thousands of applets that represent “if–then” connections between pairs of Internet services. Consumers use these applets to automate events in their daily lives. We quantitatively identify and qualitatively interpret automation assemblages that emerge bottom-up as different consumers create similar applets within unique social contexts. Our data discovery approach combines word embeddings, density-based clustering, and nonlinear dimensionality reduction with an inductive approach to the thematic analysis. We uncover 127 nested automation assemblages that correspond to automation practices. Practices are interpreted in terms of four higher-order categories: social expression, social connectedness, extended mind, and relational AI. To investigate the future trajectories of automation practices, we use the concept of the possibility space, a fundamental theoretical idea from assemblage theory. Using our empirical approach, we translate this theoretical possibility space of automation assemblages into a data visualization to predict how existing practices can grow and new practices can emerge. Our new approach makes conceptual, methodological, and empirical contributions with implications for consumer research and marketing strategy.
Changes in Container-Breeding Mosquito Diversity and Abundance Along an Urbanization Gradient are Associated With Dominance of Arboviral Vectors
Authors: Zettle MyKenna , Anderson Elsa , LaDeau Shannon L 
Published: April 2022

Abstract
Environmental conditions associated with urbanization are likely to influence the composition and abundance of mosquito (Diptera, Culicidae) assemblages through effects on juvenile stages, with important consequences for human disease risk. We present six years (2011–2016) of weekly juvenile mosquito data from distributed standardized ovitraps and evaluate how variation in impervious cover and temperature affect the composition and abundance of container-breeding mosquito species in Maryland, USA. Species richness and evenness were lowest at sites with high impervious cover (&gt;60% in 100-m buffer). However, peak diversity was recorded at sites with intermediate impervious cover (28–35%). Four species were observed at all sites, including two recent invasives (Aedes albopictus Skuse, Ae. japonicus Theobald), an established resident (Culex pipiens L), and one native (Cx. restuans Theobald). All four are viral vectors in zoonotic or human transmission cycles. Temperature was a positive predictor of weekly larval abundance during the growing season for each species, as well as a positive predictor of rapid pupal development. Despite being observed at all sites, each species responded differently to impervious cover. Abundance of Ae. albopictus larvae was positively associated with impervious cover, emphasizing that this medically-important vector not only persists in the warmer, impervious urban landscape but is positively associated with it. Positive temperature effects in our models of larval abundance and pupae occurrence in container habitats suggest that these four vector species are likely to continue to be present and abundant in temperate cities under future temperature scenarios.
Distinct Patterns of Amyloid Pathology in Autopsies of Transthyretin S77Y and A97S Amyloidosis: Significance of Symptomatology and Cell Biology
Authors: Chang Koping , Yang Wei-Kang , Li Wan-Ting , Yeh Ti-Yen , Jao Chia-Hsuan , Lin Jhih Rong , Lin Cheng Chen , Jeng Yung-Ming , Chao Chi-Chao , Hsieh Sung-Tsang 
Published: April 2022

Abstract
Hereditary transthyretin (ATTRv) amyloidosis is a systemic disease with amyloid deposition in the peripheral and autonomic nervous systems caused by mutation of transthyretin (TTR) gene. The mutant TTR S77Y is the second prevalent mutation in many countries. In Taiwan, A97S mutant accounts for more than 90% of cases. Although distinct clinical manifestations such as dysphagia, carpal tunnel syndrome, and sudden cardiac death occur, the underlying pathology has not been elucidated. Here, we report the first autopsy cases of ATTRv S77Y and A97S and comprehensively compare the pathology underlying the unique clinical manifestations. This study demonstrated the following: (1) distinct spatial patterns of amyloid deposits in peripheral nerves, with a tendency toward more amyloid deposition in the large peripheral nerves, particularly the median nerves, and scarcely in the sural nerves, and different amyloid distribution in different genotypes; (2) amyloid deposits in the conduction system of the heart in addition to surrounding cardiomyocytes; (3) extensive amyloid deposits in the larynx and gastrointestinal tract, contributing to the unique clinical symptom of dysphagia; and (4) characteristic TTR intracytoplasmic inclusions in the hepatocytes of A97S. The pathology of the first autopsied cases of ATTRv S77Y and A97S provides pathology and mechanisms underlying unique clinical manifestations.
Ethical Responsibilities of a Military to the Social Determinants of Health of its Service Members
Authors: Smith Hunter Jackson 
Published: April 2022

ABSTRACT
A military exists in a unique position. It is an organization in which active duty members knowingly join or are conscripted into service with the understanding that there is an increased risk of mental and/or bodily harm as compared to many other occupations. However, while the nature of the profession can inherently be dangerous, it does not follow that its members be placed at undue excess risk if that risk can be reasonably avoided or reduced. Social determinants of health are one example of influences under a military’s purview that impact health outcomes and well-being. Although the U.S. Military performs well across many health equity measures, disparities persist and require attention and redress. Military policies and practices deeply impact members’ lives during and after service, and the durability and profundity of these effects establish the ethical grounds upon which any military policy should be structured. The ethical obligation is fortified by the extent of control a military exercises over its personnel. Taken together, these factors necessitate a concerted effort by militaries to remain cognizant of the ethical impacts of their policies and practices and to ensure focus remains on the well-being and readiness of its personnel. As such, militaries have ethical responsibilities to promote healthy social determinants of health among their service members via policies and public health measures.
A Diagnosis You Cannot Afford to MIS-C: Multisystem Inflammatory Syndrome in Children Within the Active Duty Population
Authors: Attonito John , Edwards Isaac , Monson Michael 
Published: April 2022

ABSTRACT
Multisystem inflammatory syndrome in children (MIS-C), which is associated with coronavirus disease 2019 (COVID-19) and occurs in the immediately post-infectious period, has never-before been reported within the active duty population. It typically affects children, aged 5-13 years, but has been shown to affect those up to 20 years old. We present an 18-year-old active duty male that arrived at a military treatment facility emergency department with headache, neck pain, and shock without evidence of meningoencephalitis on cerebrospinal fluid analysis and with a negative COVID-19 test. He developed significant abdominal pain and cardiomyopathy. Chest computed tomography showed evidence of ground glass infiltrates, and repeat testing was positive for the COVID-19 virus. Multisystem inflammatory syndrome in children (MIS-C) was diagnosed and treated with a rapid improvement in the patient’s condition. It is a rare but potentially fatal condition that has been shown to affect patients up to the age of 20, encompassing a large part of the junior enlisted population. Multisystem inflammatory syndrome in children (MIS-C) can lead to death, yet mimic other diseases leading to delay of care. Thus, it should be considered when faced with the appropriate constellation of symptoms.
The matter density PDF for modified gravity and dark energy with Large Deviations Theory
Authors: Cataneo Matteo , Uhlemann Cora , Arnold Christian , Gough Alex , Li Baojiu , Heymans Catherine 
Published: April 2022

ABSTRACT
We present an analytical description of the probability distribution function (PDF) of the smoothed 3D matter density field for modified gravity and dark energy. Our approach, based on the principles of Large Deviations Theory, is applicable to general extensions of the standard Lambda cold dark matter (ΛCDM) cosmology. We show that late-time changes to the law of gravity and background expansion can be included through Einstein-de Sitter spherical collapse dynamics combined with linear theory calculations and a calibration measurement of the non-linear variance of the smoothed density field from a simple numerical simulation. In a comparison to N-body simulations for f(R), DGP, and evolving dark energy theories, we find per cent level accuracy around the peak of the distribution for predictions in the mildly non-linear regime. A Fisher forecast of an idealized experiment with a Euclid-like survey volume demonstrates the power of combining measurements of the 3D matter PDF with the 3D matter power spectrum. This combination is shown to halve the uncertainty on parameters for an evolving dark energy model, relative to a power spectrum analysis on its own. The PDF is also found to substantially increase the detection significance for small departures from General Relativity, with improvements of up to six times compared to the power spectrum alone. This analysis is therefore very promising for future studies including non-Gaussian statistics, as it has the potential to alleviate the reliance of these analyses on expensive high-resolution simulations and emulators.
Trajectories and radiation of charged particles in the pulsar magnetosphere
Authors: Chang Shan , Zhang Li , Jiang Zejun , Li Xiang 
Published: April 2022

ABSTRACT
Trajectories and radiation of the accelerating electrons are studied in the pulsar magnetosphere approximated as the electromagnetic field of the Deutsch’s solutions. Because the electrons are accelerated rapidly to ultra-relativistic velocity near the neutron star surface, the electron velocity vector (and then its trajectory) is derived from the balance between Lorentz force and radiation reaction force, which makes the pitch angle between electron trajectories and magnetic field lines non-zero in most part of the magnetosphere. In such a case, the spectral energy distributions (SEDs) of synchro-curvature radiation for the accelerating electrons with a mono-energetic form are calculated. Our results indicate that: (i) the pitch angle is the function of electron position (r, θ, ϕ) in the open field line regions, and increases with increasing r and θ as well as increasing the inclination angle; (ii) the radius of curvature becomes large along the particle trajectory, and (iii) the SED appears a double peak structure depending on the emission position, where the synchrotron radiation plays an important role in X-ray band and curvature radiation mainly works in GeV band, which is only determined by parameters α and ζ.
Beyond mass: detecting secondary halo properties with galaxy-galaxy lensing
Authors: Xhakaj Enia , Leauthaud Alexie , Lange Johannes , Hearin Andrew , Diemer Benedikt , Dalal Neal 
Published: April 2022

ABSTRACTSecondary halo properties beyond mass, such as the mass accretion rate (MAR), concentration, and the half mass scale, are essential in understanding the formation of large-scale structure and dark matter haloes. In this paper, we study the impact of secondary halo properties on the galaxy-galaxy lensing observable, ΔΣ. We build an emulator trained on N-body simulations to model ΔΣ and quantify the impact of different secondary parameters on the ΔΣ profile. We focus on the impact of MAR on ΔΣ. We show that a 3σ detection of variations in MAR at fixed halo mass could be achieved with the Hyper Suprime Cam survey assuming no baryonic effects and a proxy for MAR with scatter &lt;1.5. We show that the full radial profile of ΔΣ depends on secondary properties at fixed halo mass. Consequently, an emulator that can perform full shape fitting yields better than two times improvement upon the constraints on MAR than only using the outer part of the halo. Finally, we highlight that miscentring and MAR impact the radial profile of ΔΣ in a similar fashion, implying that miscentring and MAR need to be modelled jointly for unbiased estimates of both effects. We show that present-day lensing data sets have the statistical capability to place constraints on halo MAR within our assumptions. Our analysis opens up new possibilities for observationally measuring the assembly history of the dark matter haloes that host galaxies and clusters.
Long-term 3D MHD simulations of black hole accretion discs formed in neutron star mergers
Authors: Fahlman Steven , Fernández Rodrigo 
Published: April 2022

ABSTRACT
We examine the long-term evolution of accretion tori around black hole (BH) remnants of compact object mergers involving at least one neutron star, to better understand their contribution to kilonovae and the synthesis of r-process elements. To this end, we modify the unsplit magnetohydrodynamic (MHD) solver in flash 4.5 to work in non-uniform three-dimensional spherical coordinates, enabling more efficient coverage of a large dynamic range in length scales while exploiting symmetries in the system. This modified code is used to perform BH accretion disc simulations that vary the initial magnetic field geometry and disc compactness, utilizing a physical equation of state, a neutrino leakage scheme for emission and absorption, and modelling the BH’s gravity with a pseudo-Newtonian potential. Simulations run for long enough to achieve a radiatively inefficient state in the disc. We find robust mass ejection with both poloidal and toroidal initial field geometries, and suppressed outflow at high disc compactness. With the included physics, we obtain bimodal velocity distributions that trace back to mass ejection by magnetic stresses at early times, and to thermal processes in the radiatively inefficient state at late times. The electron fraction distribution of the disc outflow is broad in all models, and the ejecta geometry follows a characteristic hourglass shape. We test the effect of removing neutrino absorption or nuclear recombination with axisymmetric models, finding ${\sim} 50{{\ \rm per\ cent}}$ less mass ejection and more neutron-rich composition without neutrino absorption, and a subdominant contribution from nuclear recombination. Tests of the MHD and neutrino leakage implementations are included.
fBLS – a fast-folding BLS algorithm
Authors: Shahaf S , Zackay B , Mazeh T , Faigler S , Ivashtenko O 
Published: April 2022

ABSTRACTWe present fBLS – a novel fast-folding technique to search for transiting planets, based on the fast-folding algorithm (FFA), which is extensively used in pulsar astronomy. For a given light curve with N data points, fBLS simultaneously produces all the binned phase-folded light curves for an array of Np trial periods. For each folded light curve produced by fBLS, the algorithm generates the standard BLS periodogram and statistics. The number of performed arithmetic operations is $\mathcal {O}(N_p\cdot \log N_p)$, while regular BLS requires $\mathcal {O}(N_p\cdot N)$ operations. fBLS can be used to detect small rocky transiting planets, with periods shorter than one day, a period range for which the computation is extensive. We demonstrate the capabilities of the new algorithm by performing a preliminary fBLS search for planets with ultra-short periods in the Kepler main-sequence light curves. In addition, we developed a simplistic signal validation scheme for vetting the planet candidates. This two-stage preliminary search identified all-known ultra-short planet candidates and found three new ones.
Are the newly-discovered z ∼ 13 drop-out sources starburst galaxies or quasars?
Authors: Pacucci Fabio , Dayal Pratika , Harikane Yuichi , Inoue Akio K , Loeb Abraham 
Published: April 2022

ABSTRACT
The detection of two z ∼ 13 galaxy candidates has opened a new window on galaxy formation at an era only 330 Myr after the big bang. Here, we investigate the physical nature of these sources: are we witnessing star forming galaxies or quasars at such early epochs? If powered by star formation, the observed ultraviolet (UV) luminosities and number densities can be jointly explained if: (i) these galaxies are extreme star-formers with star formation rates 5−24 × higher than those expected from extrapolations of average lower-redshift relations; (ii) the star formation efficiency increases with halo mass and is countered by increasing dust attenuation from z ∼ 10−5; (iii) they form stars with an extremely top-heavy initial mass function. The quasar hypothesis is also plausible, with the UV luminosity produced by black holes of $\sim 10^8 \, \rm M_\odot$ accreting at or slightly above the Eddington rate (fEdd ∼ 1.0). This black hole mass at z ∼ 13 would require very challenging, but not implausible, growth parameters. If spectroscopically confirmed, these two sources will represent a remarkable laboratory to study the Universe at previously inaccessible redshifts.
Different Genes are Recruited During Convergent Evolution of Pregnancy and the Placenta
Authors: Foster Charles S.P. , Van Dyke James U. , Thompson Michael B. , Smith Nicholas M.A. , Simpfendorfer Colin A. , Murphy Christopher R. , Whittington Camilla M. 
Published: April 2022

AbstractThe repeated evolution of the same traits in distantly related groups (convergent evolution) raises a key question in evolutionary biology: do the same genes underpin convergent phenotypes? Here, we explore one such trait, viviparity (live birth), which, qualitative studies suggest, may indeed have evolved via genetic convergence. There are &gt;150 independent origins of live birth in vertebrates, providing a uniquely powerful system to test the mechanisms underpinning convergence in morphology, physiology, and/or gene recruitment during pregnancy. We compared transcriptomic data from eight vertebrates (lizards, mammals, sharks) that gestate embryos within the uterus. Since many previous studies detected qualitative similarities in gene use during independent origins of pregnancy, we expected to find significant overlap in gene use in viviparous taxa. However, we found no more overlap in uterine gene expression associated with viviparity than we would expect by chance alone. Each viviparous lineage exhibits the same core set of uterine physiological functions. Yet, contrary to prevailing assumptions about this trait, we find that none of the same genes are differentially expressed in all viviparous lineages, or even in all viviparous amniote lineages. Therefore, across distantly related vertebrates, different genes have been recruited to support the morphological and physiological changes required for successful pregnancy. We conclude that redundancies in gene function have enabled the repeated evolution of viviparity through recruitment of different genes from genomic “toolboxes”, which are uniquely constrained by the ancestries of each lineage.
Genomic characterisation reveals a dominant lineage of SARS-CoV-2 in Papua New Guinea
Authors: Palou Theresa , Wilmot Mathilda , Duchene Sebastian , Porter Ashleigh , Kemoi Janlyn , Suarkia Dagwin , Andersson Patiyan , Watt Anne , Sherry Norelle , Seemann Torsten , Sait Michelle , Turharus Charlie , Nguyen Son , Schlebusch Sanmarié , Thompson Craig , McMahon Jamie , Vaccher Stefanie , Lin Chantel , Esoram Danoi , Howden Benjamin P , Susapu Melinda 
Published: April 2022

Abstract
The coronavirus disease pandemic has highlighted the utility of pathogen genomics as a key part of comprehensive public health response to emerging infectious diseases threats, however, the ability to generate, analyse, and respond to pathogen genomic data varies around the world. Papua New Guinea (PNG), which has limited in-country capacity for genomics, has experienced significant outbreaks of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) with initial genomics data indicating a large proportion of cases were from lineages that are not well defined within the current nomenclature. Through a partnership between in-country public health agencies and academic organisations, industry, and a public health genomics reference laboratory in Australia a system for routine SARS-CoV-2 genomics from PNG was established. Here we aim to characterise and describe the genomics of PNG’s second wave and examine the sudden expansion of a lineage that is not well defined but very prevalent in the Western Pacific region. We generated 1797 sequences from cases in PNG and performed phylogenetic and phylodynamic analyses to examine the outbreak and characterise the circulating lineages and clusters present. Our results reveal the rapid expansion of the B.1.466.2 and related lineages within PNG, from multiple introductions into the country. We also highlight the difficulties that unstable lineage assignment causes when using genomics to assist with rapid cluster definitions.
CircLDLR Modulates the Proliferation and Apoptosis of Vascular Smooth Muscle Cells in Coronary Artery Disease Through miR-26-5p/KDM6A Axis
Authors: Dai Huangdong , Zhao Naishi , Zheng Yue 
Published: April 2022

Abstract:
The purpose of this study was to investigate the effect of circLDLR on the proliferation and apoptosis of vascular smooth muscle cells (VSMCs) in coronary artery disease and its regulatory mechanism. The expression of KDM6A was detected by qRT-PCR or Western blot. VSMCs were transfected with miR-26-5p mimic/inhibitor or OE KDM6A. Cell proliferation and apoptosis were assessed. Luciferase reporter gene assays were used to examine interactions between miR-26-5p and KDM6A in VSMCs. Downregulation of circLDLR was associated with increased miR-26-5p in coronary artery disease tissues. In addition, circLDLR could inhibit cell proliferation and promote cell apoptosis by regulating miR-26-5p. Moreover, the overexpression of KDM6A reduced VSMCs proliferation and increased apoptosis in an miR-26-5p/circLDLR axis–dependent manner. CircLDLR modulates the proliferation and apoptosis of VSMCs through miR-26-5p/KDM6A axis.