bluuebunny/crossref_metadata_2025_split huggingface dataset:
Interpleural location of chest drain on ultrasound excludes pneumothorax and associates with a low degree of chest drain foreshortening on the antero-posterior chest X-ray
Authors: Maly Michal , Mokotedi Masego Candy , Svobodova Eva , Flaksa Marek , Otahal Michal , Stach Zdenek , Rulisek Jan , Brozek Tomas , Porizka Michal , Balik Martin 
Published: November 2022

AbstractBackgroundThe role of chest drain (CD) location by bedside imaging methods in the diagnosis of pneumothorax has not been explored in a prospective study yet.MethodsCovid-19 ARDS patients with pneumothorax were prospectively monitored with chest ultrasound (CUS) and antero-posterior X-ray (CR) performed after drainage in the safe triangle. CD foreshortening was estimated as a decrease of chest drain index (CDI = length of CD in chest taken from CR/depth of insertion on CD scale + 5 cm). The angle of inclination of the CD was measured between the horizontal line and the CD at the point where it enters pleural space on CR.ResultsOf the total 106 pneumothorax cases 80 patients had full lung expansion on CUS, the CD was located by CUS in 69 (86%), the CDI was 0.99 (0.88–1.06). 26 cases had a residual pneumothorax after drainage (24.5%), the CD was located by CUS in 31%, the CDI was 0.76 (0.6–0.93),p < 0.01. The risk ratio for a pneumothorax in a patient with not visible CD between the pleural layers on CUS and an associated low CDI on CR was 5.97,p˂0.0001. For the patients with a steep angle of inclination (> 50°) of the CD, the risk ratio for pneumothorax was not significant (p < 0.17). A continued air leak from the CD after drainage is related to the risk for a residual pneumothorax (RR 2.27,p = 0.003).ConclusionAbsence of a CD on CUS post drainage, low CDI on CR and continuous air leak significantly associate with residual occult pneumothorax which may evade diagnosis on an antero-posterior CR.
The growth characteristics and lignans contents of Schisandra chinensis fruits from different cultivation regions
Authors: Lee Dong Hwan , Park Youngki , Jang Jun Hyuk , Son Yonghwan , Kim Ji Ah , Lee Sun-Young , Kim Hyun-Jun 
Published: November 2022

AbstractWe developed and validated an optimized method for quantifying lignans using ultra-performance liquid chromatography (UPLC) and performs correlation analysis of growth characteristics and contents of lignans. The methods for determining lignans were validated by measuring the linearity, limit of detection (LOD), limit of quantification (LOQ), accuracy, and precision using UPLC. All calibration curves showed good linearity (r2 ≥ 0.9998) within the tested ranges. The limit of detection (LOD) and limit of quantification (LOQ) were 0.003–0.02 µg/mL and 0.01–0.07 µg/mL, respectively. The precision of analysis was less than 3%. The recoveries of quantified compounds ranged from 98.4 to 101.68%. Growth characteristics of fruits were negatively correlated with content of total marker compounds. The results of this study can be used to quality-control of S. chinensis fruits used as medicinal raw materials.
Lessons from the Chinese imperial examination system
Authors: O’Sullivan Barry , Cheng Liying 
Published: November 2022

Abstract
In this paper, we set out to explore the world’s first major standardised examination system. In the field of language testing and assessment, works such as measured words (Spolsky, 1995), measured constructs (Weir, Vidakovic & Galaczi, 2013), and Cambridge English exams — the first hundred years (Hawkey & Milanovic, 2013) all point to the fact that contemporary tests reflect many years of accumulated knowledge and practice. Perhaps more importantly, they also remind us of the social and educational impact of the tests we develop. With this in mind, we explore the very first example of a standardised examination system — the Chinese imperial examination system (the Kējǔ — in Chinese Hanyu Pinyin 科举).
A brief survey on big data: technologies, terminologies and data-intensive applications
Authors: Abdalla Hemn Barzan 
Published: November 2022

AbstractThe technical advancements and the availability of massive amounts of data on the Internet draw huge attention from researchers in the areas of decision-making, data sciences, business applications, and government. These massive quantities of data, known as big data, have many benefits and applications for researchers. However, the use of big data consumes a lot of time and imposes enormous computational complexity. This survey describes the significance of big data and its taxonomy and details the basic terminologies used in big data. It also discusses the technologies used in big data applications as well as their various complexities and challenges. The survey focuses on the various techniques presented in the literature to restrain the issues associated with big data. In particular, the review concentrates on big data techniques in accordance with processing, security, and storage. It also discusses the various parameters associated with big data, such as availability and velocity. The study analyses big data terminologies and techniques in accordance with several factors, such as year of publication, performance metrics, achievement of the existing models, and methods utilized. Finally, this review article describes the future direction of research and highlights big data possibilities and solicitations with a detailed sketch of the big data processing frameworks.
Comparison of protocols with respiratory-gated (4D) motion compensation in PET/CT: open-source package for quantification of phantom image quality
Authors: Martinez-Movilla Andrea , Mix Michael , Torres-Espallardo Irene , Teijeiro Elena , Bello Pilar , Baltas Dimos , Martí-Bonmatí Luis , Carles Montserrat 
Published: November 2022

Abstract
Background
Patient’s breathing affects the quality of chest images acquired with positron emission tomography/computed tomography (PET/CT) studies. Movement correction is required to optimize PET quantification in clinical settings. We present a reproducible methodology to compare the impact of different movement compensation protocols on PET image quality. Static phantom images were set as reference values, and recovery coefficients (RCs) were calculated from motion compensated images for the phantoms in respiratory movement. Image quality was evaluated in terms of: (1) volume accuracy (VA) with the NEMA phantom; (2) concentration accuracy (CA) by six refillable inserts within the electron density CIRS phantom; and (3) spatial resolution (R) with the Jaszczak phantom. Three different respiratory patterns were applied to the phantoms. We developed an open-source package to automatically analyze VA, CA and R. We compared 10 different movement compensation protocols available in the Philips Gemini TF-64 PET/CT (4-, 6-, 8- and 10-time bins, 20%-, 30%-, 40%-window width in Inhale and Exhale).

Results
The homemade package provided RC values for VA, CA and R of 102 PET images in less than 5 min. Results of the comparison of the 10 different protocols demonstrated the feasibility of the proposed method for quantifying the variations observed qualitatively. Overall, prospective protocols showed better motion compensation than retrospective. The best performance was obtained for the protocol Exhale 30% (0.3 s after maximum Exhale position and window width of 30%) with RC$$_{VA}=1.6\pm 1.3$$

VA

=
1.6
±
1.3

, RC$$_{CA}=0.90\pm 0.09$$

CA

=
0.90
±
0.09

and RC$$_{R}=0.6 \pm 0.4$$

R

=
0.6
±
0.4

. Among retrospective protocols, 8 Phase protocol showed the best performance.

Conclusion
We provided an open-source package able to automatically evaluate the impact of motion compensation methods on PET image quality. A setup based on commonly available experimental phantoms is recommended. Its application for the comparison of 10 time-based approaches showed that Exhale 30% protocol had the best performance. The proposed framework is not specific to the phantoms and protocols presented on this study.
Surgical approach for appendicitis in neutropenia: a case report and review of the literature
Authors: Uthayanan Ushanthan , Kolb Walter , Schmied Bruno , Bischofberger Stephan 
Published: November 2022

Abstract
Background
Acute appendicitis is a common abdominal pathology, particularly in younger patients presenting with abdominal pain. The clinical presentation is typically characterized by right lower quadrant pain (with local peritonitis) accompanied by fever and nausea. In neutropenic patients it is challenging to diagnose acute appendicitis. It is much more challenging because the characteristic symptoms are different, and diagnosis may be delayed or missed.

Case presentation
We present the case of a 33-year-old Caucasian male patient with fever, abdominal pain, and an absolute granulocyte count of 0 × 109/L. Abdominal CT demonstrated an uncomplicated acute appendicitis. We initiated a conservative in-hospital treatment with intravenous antibiotic therapy and simultaneous bone marrow stimulation, with close monitoring. On day three, there was evidence of monocyte increase, one of the first signs of bone marrow regeneration, and delayed laparoscopic appendectomy was performed. The perioperative and postoperative course was uneventful.

Conclusion
We discuss the different treatment strategies in patients with neutropenia presenting with acute appendicitis (i.e., conservative management, delayed appendectomy, and immediate appendectomy) based on our experience and a review of the literature. In summary, delayed laparoscopic appendectomy at the onset of granulocyte regeneration under antibiotic and G-CSF therapy represents a viable surgical option for adults as well as for children and should be discussed compared with conservative therapy.
Government intervention model based on behavioral heterogeneity for China’s stock market
Authors: Zhou Zhong-Qiang , Li Jie , Zhang Wei , Xiong Xiong 
Published: November 2022

AbstractActive government intervention is a striking characteristic of the Chinese stock market. This study develops a behavioral heterogeneous agent model (HAM) comprising fundamentalists, chartists, and stabilizers to investigate investors’ dynamic switching mechanisms under government intervention. The model introduces a new player, the stabilizer, into the HAM as a proxy for the government. We use the model to examine government programs during the 2015 China stock market crash and find that it can replicate the dynamics of investor sentiment and asset prices. In addition, our analysis of two simulations, specifically the data-generating processes and shock response analysis, further corroborates the key conclusion that our intervention model not only maintains market stability but also promotes the return of risk asset prices to their fundamental values. The study concludes that government interventions guided by the new HAM can alleviate the dilemma between reducing price volatility and improving price efficiency in future intervention programs.
Exploring the “how” in research partnerships with young partners by experience: lessons learned in six projects from Canada, the Netherlands, and the United Kingdom
Authors: Nguyen Linda , van Oort Bente , Davis Hanae , van der Meulen Eline , Dawe-McCord Claire , Franklin Anita , Gorter Jan Willem , Morris Christopher , Ketelaar Marjolijn 
Published: November 2022

AbstractBackgroundInvolvement of young partners by experience in research is on the rise and becoming expected practice. However, literature on how to promote equitable and meaningful involvement of young people is scarce. The purpose of this paper is to describe and reflect on different approaches between researchers and young partners by experience based on six research projects conducted in Canada, Netherlands, and United Kingdom.MethodsFrom six exemplar research projects, at least one researcher and one young partner by experience were asked to collaboratively (1) describe the project; (2) summarise the values and practicalities of the project; and (3) reflect on their partnership. Thematic analysis was applied to the findings from these reflective exercises, which included meeting summaries, recordings, and notes.ResultsAll projects shared similar values, including mutual respect between all team members. Young partners were offered a variety of opportunities and approaches to being involved, for example in recruiting participants, co-analysing or (co-)presenting results. Supports were provided to the teams in a variety of ways, including organizing accessible meetings and having dedicated facilitators. Regular and proactive communication was encouraged by using asynchronous modes of communication, establishing reference documents, and a personal approach by facilitators. Facilitators aimed to tailor the needs of all team members by continuously discussing their preferred roles in the project. While most projects did not offer formal research training, various learning and skill development opportunities were provided throughout, including presenting skills or advocacy training.ConclusionWith this paper, we demonstrated the value of reflection, and we invite others to reflect on their partnerships and share their lessons learned. Our recommendations for involvement of young people in research are: (1) Remember that it is okay to not know what the partnership might look like and there is no single recipe of how to partner; (2) Take the time to invest in partnerships; (3) Provide ongoing opportunities to reflect on partnerships; (4) Consider how to balance the power dynamics; and (5) Consider how to incorporate diversity in the background of young partners in research.
Super-selective and staged glue embolization for labral AVMs using ultra-thin microcatheters: report of two cases
Authors: Sawano Miyuki , Tanoue Shuichi , Tanaka Norimitsu , Koganemaru Masamichi , Kuhara Asako , Kugiyama Tomoko , Shinjo Yasumoto , Abe Toshi 
Published: November 2022

Abstract
Background
Treating arteriovenous malformation (AVM) is challenging because of the high recurrence rate and because incomplete resection or embolization can induce aggressive growth. However, a standard strategy is not fully established. Although transcatheter arterial embolization (TAE) is currently almost always part of the treatment, in many cases, single treatment is not curative and only palliative. Additionally, the success and complication rates associated with TAE alone are unclear, and there has been limited study of staged TAE for facial AVMs. Furthermore, few reports have described the details of the procedure.

Case-presentation
We report two cases of AVM of the upper lip in patients who were successfully treated by staged super-selective TAE at several-month intervals using ultra-thin microcatheters and n-butyl-2-cyanoacrylate.

Conclusion
Staged and super-selective TAE may prevent complications and provide high curability and might be a useful treatment in cases of AVM.
The role of miRNAs in viral myocarditis, and its possible implication in induction of mRNA-based COVID-19 vaccines-induced myocarditis
Authors: AbdelMassih Antoine , Agha Hala , El-Saiedi Sonia , El-Sisi Amal , El Shershaby Meryam , Gaber Hanya , Ismail Habiba-Allah , El-Husseiny Nadine , Amin Abeer Reda , ElBoraie Aly , Ayad Aya , Menshawey Esraa , Sefein Fady , Osman Ibrahim Ihab , Moursi Mai , Hanafy Maram , Abdelaziz Mariam Sherif , Arsanyous Mariem Badr , Khaled-Ibn-El-Walid Mariam , Tawfik Marwa Gamal , Habib Menna , Mansour Mina Ehab , Ashraf Mirette , Khattab Mohamed Ayman , Alshehry Nada , Hafez Nada , ElDeeb Naheel Essam , Ashraf Nirvana , Khalil Noha , AbdElSalam Noheir Ismail , Shebl Noura , Hafez Nouran Gamal Ali , Youssef Nourhan Hatem , Bahnan Odette , Ismail Passant , Kelada Peter , Menshawey Rahma , Saeed Rana , Husseiny Reem Jalal , Yasser Reem , Sharaf Safa , Adel Veronia , Naeem Youstina , Nicola Youstina Nagy Farid , Kamel Aya , Hozaien Rafeef , Fouda Raghda 
Published: November 2022

Abstract
Background
Several reports of unheeded complications secondary to the current mass international rollout of SARS-COV-2 vaccines, one of which is myocarditis occurring with the FDA fully approved vaccine, Pfizer, and others.

Main body of the abstract
Certain miRNAs (non-coding RNA sequences) are involved in the pathogenesis in viral myocarditis, and those miRNAs are interestingly upregulated in severe COVID-19. We hypothesize that the use of mRNA-based vaccines may be triggering the release of host miRNAs or that trigger the occurrence of myocarditis. This is based on the finding of altered host miRNA expression promoting virus-induced myocarditis.

Short conclusion
In conclusion, miRNAs are likely implicated in myocarditis associated with mRNA vaccines. Our hypothesis suggests the use of miRNA as a biomarker for the diagnosis of mRNA vaccine-induced myocarditis. Additionally, the interplay between viral miRNA and the host immune system could alter inflammatory profiles, hence suggesting the use of therapeutic inhibition to prevent such complications.
An integration into the diagnostic workflow in a pediatric patient suspected of having Marfan syndrome
Authors: Oro Maria , Tarsitano Marina , Rivieccio Maria , Piscopo Carmelo , Petti Maria Teresa , Bukvic Nenad , Della Monica Matteo , Chetta Massimiliano 
Published: November 2022

Abstract
Background
The genetic approach to Marfan syndrome (MFS) has evolved over the last few decades, as has our understanding of the variants’ potential structural and functional consequences. It has been proposed that next-generation sequencing be used to improve genetic diagnosis and patient management. To this end, we used a targeted NGS custom panel to perform genetic analysis in a patient with MFS and his or her family members.

Case presentation
Here, we describe a novel germ-line heterozygous missense variant (transversion c.5371 T > A) found in exon 43 of the FBN1 gene of a patient (proband) with MFS. FBN1 (ENSG0000166147) and TGFB2 (ENSG0000166147) were included in a targeted sequencing panel for MFS (ENSG0000163513). This new variant c.5371 T > A was identified only in the proband, not in unaffected family members or healthy controls.

Conclusions
Given the massive amount of data generated by gene panel analysis, clinical interpretation of genetic variants may become more difficult. As a result, 3D modeling and multidisciplinary approaches should be used in the analysis and annotation of observed variants. The analysis of the protein’s conformational structure in relation to the identified variant could provide useful information. These data can be used to classify observed variants (pathogenic vs non-pathogenic) linked to the MFS phenotype, as well as to track disease progression and potential target treatments.
Oncology Providers' and Professionals' Experiences With Suicide Risk Screening Among Patients With Head and Neck Cancer: A Qualitative Study
Authors: Turner Kea , Stover Angela M. , Tometich Danielle B. , Geiss Carley , Mason Arianna , Nguyen Oliver T. , Hume Emma , McCormick Rachael , Powell Sean , Hallanger-Johnson Julie , Patel Krupal B. , Kirtane Kedar S. , Jammigumpula Neelima , Moore Colin , Perkins Randa , Rollison Dana E. , Jim Heather S.L. , Oswald Laura B. , Crowder Sylvia , Gonzalez Brian D. , Robinson Edmondo , Tabriz Amir Alishahi , Islam Jessica Y. , Gilbert Scott M. 
Published: November 2022

PURPOSE: There has been limited study of the implementation of suicide risk screening for patients with head and neck cancer (HNC) as a part of routine care. To address this gap, this study assessed oncology providers' and professionals' perspectives about barriers and facilitators of implementing a suicide risk screening among patients with HNC. MATERIALS AND METHODS: All patients with HNC with an in-person visit completed a suicide risk screening on an electronic tablet. Patients reporting passive death wish were then screened for active suicidal ideation and referred for appropriate intervention. Interviews were conducted with 25 oncology providers and professionals who played a key role in implementation including nurses, medical assistants, patient access representatives, advanced practice providers, physicians, social workers, and informatics staff. The interview guide was based on the Consolidated Framework for Implementation Research. Interviews were transcribed and analyzed for themes. RESULTS: Participants identified multilevel implementation barriers, such as intervention level (eg, patient difficulty with using a tablet), process level (eg, limited nursing engagement), organizational level (eg, limited clinic Wi-Fi connectivity), and individual level (eg, low clinician self-efficacy for interpreting and acting upon patient-reported outcome scores). Participants noted facilitators, such as effective care coordination across nursing and social work staff and the opportunity for patients to be screened multiple times. Participants recommended strengthening patient and clinician education and providing patients with other modalities for data entry (eg, desktop computer in the waiting room). CONCLUSION: Participants identified important intervention modifications that may be needed to optimize suicide risk screening in cancer care settings.
Knowledge of perianal Crohn's disease among nurses in an Italian tertiary centre
Authors: Napolitano Daniele , Cioffi Federica , Marocchini Giannina , Bernabei Tiziana , Leonetti Alessia , Fanali Caterina , Orgiana Nicoletta , Amatucci Valeria , Gasbarrini Antonio , Ratto Carlo , Litta Francesco , Scaldaferri Franco 
Published: November 2022

Background: Patients with Crohn's disease can develop anal and perianal lesions, such as fistulas, ulcers, skin tags, perianal abscesses and strictures. Perianal Crohn's disease (PCD) is a condition that has a major impact on patients' quality of life. The multidisciplinary team includes a nurse who manages the patient according to evidence-based medicine. Clinical practice and post-registration training are the way forward for nurses to acquire the skills needed to deliver quality care. Aims: This study explored the assessment of nurses' knowledge of PCD. A cross-sectional survey was used to look at the nurses' knowledge. Methods: The questionnaire was administered over 2 months, between September and October 2019. The questionnaire was anonymous, validated by a panel of experts in the field and consisted of 30 questions to assess knowledge and two questions to assess the need for training. It was directed to 120 clinical nurses in the departments of medicine and abdominal surgery. Results: There were 120 nurses enrolled, and 64.2% of nurses had cared for patients with PCD at least once. The survey showed a fairly low level of knowledge of the diagnostic and therapeutic care pathways for patients affected by PCD. On the other hand, a high need for training and in-depth study of the subject emerged. Conclusion: The nurse, an integral part of the multidisciplinary team, plays an important role in the education of these patients. Nurses' present level of knowledge can certainly be improved thanks to their willingness to undertake training courses or to use information tools.