bluuebunny/crossref_metadata_2025_split huggingface dataset:
Techniques of surgical hemostasis and sealing after laparoscopic partial nephrectomy
Authors: Nosov A. K. , Mamizhev E. M. , Shchekuteev N. A. , Semeyko D. P. , Lushina P. A. , Rumyantseva D. I. , Berkut M. V. 
Published: December 2022

Background. The kidney cancer treatment remains cornerstone problem in our country for healthcare. Survival results of partial nephrectomy as a radical nephrectomy are similar in groups of patients with the same morphological features and was confirmed by previously results: “indications for nephron-sparing treatment of kidney cancer is determined with the degree of resectability, assessed subjectively by surgeon and his experience, ambitions and technical capabilities. It does not depend on oncological prognostic factors”. This thesis is actual due to oncological preoperative factors and limited only by tumor size. Therefore, development of technical capabilities, techniques and skills expand our capabilities in organ-preserving treatment.Aim. To evaluate the effectiveness and safety of bipolar coagulation with fibrin glue in comparison with the standard technique of surgical suture to the area of non-ischemic partial nephrectomy.Materials and methods. This is prospective trial which had included the results of treatment of 121 patients who received partial-nephrectomy for localized kidney cancer from 2015 to 2017 at the N.N. Petrov National Medical Research Center of Oncology. Two variants of hemostasis were used in the work: standard surgical (surgical suture) and electrohemostasis with an additional hemostatic component (fibrin glue). Among the selected patients, there were no patients with a single kidney and a pronounced violation of the excretory function of the organ.Results. The groups were comparable in terms of tumor size (р = 0.09), morphometric characteristics according to the R.E.N.A.L. scale (p = 0.07), no differences were found in clinical and morphological staging. The use of electrohemostasis with a hemostatic glue component did not significantly affect at the excretory function of the kidney, assessed on the 3rd and 10th days after laparoscopic non-ischemic resection, which indirectly confirms the functional safety of the tested technique (р >0.05). The groups did not differ significantly in terms of the blood loss, hemotransfusions (р = 0.067), and none of delayed bleeding was found which indicates the reliability of electrohemostasis using an adhesive composition.Conclusion. We proposed a patent “Method of surgical hemostasis in laparoscopic partial nephrectomy” RU2654402C1 by combining bipolar coagulation in the 90 W-effect 7–8 mode and hemostatic fibrin glue (SURGIFLO, PERCLOT). Used adhesive compositions complement the achieved electrohemostasis, and also provide sealing of the area of the resected kidney tissue.
Evaluation of quality of life of patients with solitary renal cancer metastases in bones before and after surgical treatment in combination with targeted therapy and without it
Authors: Kostritskiy S. V. , Shirokorad V. I. , Alekseev B. Ya. , Semenov D. V. , Kalpinskiy A. S. , Korneva Yu. S. 
Published: December 2022

Background. Currently, treatment tactics for oligometastatic renal cancer are a debatable topic due to relatively localized process and high risk of skeletal-related events (SRE). Therefore, the effect of treatment on quality of life of these patients is an important subject.Aim. To evaluate quality of life of patients with solitary renal cancer metastases in the bones before and after surgical treatment in combination with targeted therapy and without it.Materials and methods. The study included 64 patients with solitary bone metastases and symptoms of SRE. The patients underwent surgical treatment due to solitary bone metastases of renal cancer in combination with targeted therapy (1st group; n = 25) and without targeted therapy (2nd group; n = 39). The effects of surgical treatment on patients’ condition were evaluated using the EORTC-QLQ-C30 questionnaire.Results. In the 1st group, no statistically significant differences were shown for 8 of 30 indicators of the EORTC-QLQ-C30 questionnaire: restrictions in daily activities, dyspnea, appetite loss, nausea, vomiting, fatigue, tension, financial difficulties. The rest of the indicators showed statistically significant shift toward improvement. In the 2nd group, 7 of 30 indicators did not show statistically significant differences: restrictions in daily activities, dyspnea, sleep disorders, appetite loss, diarrhea, tension, financial difficulties. The rest of the questionnaire points also showed improvement (especially in decreased pain syndrome). In patients of the 2nd group before and after surgery, need for rest, fatigue, appetite loss and restrictions in performing work were more pronounced than in the 1st group. Additionally, after surgery patients of this group required more time in the chair and had more frequent diarrhea, while prior to surgery they complained more of nausea and fatigue. The last 2 parameters evaluating overall quality of life were higher in the 1st group before and after surgery which shows better baseline condition of these patients which was not affected by the treatment.Conclusion. Therefore, surgical treatment of renal cancer bone metastases both in combination with targeted therapy and without it significantly improves quality of life according to the results of quality of life evaluation using the EORTC-QLQ-C30 questionnaire in patients of the studied groups.
Serotype-independent protective activity of recombinant pneumolysin in a model of systemic infection caused by <i>Streptococcus pneumoniae</i> serotypes 4 and 6B
Authors: Vorobyev D. S. , Petukhova E. S. , Volokh Yu. V. , Afanasyeva O. М. , Tokarskaya M. M. , Leonova A. Yu. , Zhigunova O. V. , Semenova I. B. , Gavrilova N. F. , Yakovleva I. V. , Yastrebova N. E. 
Published: December 2022

Background. The development of a pneumococcal vaccine with serotype-independent activity is relevant for the whole world, as this is due to the high prevalence of Streptococcus pneumoniae (S. pneumoniae), the constant change of pathogen serotypes and the growth of antibiotic-resistant strains. In previous experiments, we revealed a protective effect of immunization with recombinant pneumolysin (rPly) in a model of systemic infection caused by S. pneumoniae serotype 3.Aim. Study of serotype-independent protective activity of rPly.Materials and methods. Strains of S. pneumoniae serotypes 4 and 6B were used. Mice were immunized intraperi-toneally two or three times with an interval of 14 days with rPly. To assess the protective activity of rPly, animals after double or triple immunization were infected intraperitoneally with S. pneumoniae .Results. rPly at a triple immunization in a dose of 25 μg protected mice from intraperitoneal infection with S. pneu- moniae serotype 4, the efficiency index increased by 2 times compared with the control. with a double immunization, rPly protected mice from intraperitoneal infection with S. pneumoniae serotype 6B, efficiency index increased by 6.61 times compared with the control.Conclusion. rPly protects animals from infection with different serotypes of S. pneumoniae, which allows us to consider it a promising drug for the development of pneumococcal vaccines with serotype-independent activity.
Clinical Application of the Persian Version of Buffalo Model Questionnaire by examining Its correlation with the Buffalo Model Test Battery
Authors: Jarollahi Farnoush , Jalaie Shoreh , Ahadi Mohsen , Ahmadi Zohreh , Khamisabadi Saeedeh 
Published: December 2022

Background and Aim: The Buffalo Model Questionnaire (BMQ) has been proposed for the screening, helping to diagnose and also monitoring the effect of rehabilitation on the improvement of Central Auditory Processing Disorder ((C)APD). In this regard, the applicability and accuracy of Persian-BMQ (P-BMQ) are evaluated by examining the correlation between the results of this questionnaire and the Buffalo model test battery.
Methods: Overall, 254 children, normal and with Specific Learning Disorder (SLD) aged between 7–12 years old participated in this cross-sectional study. The questionnaire was completed by the parents of children who were subjected to the Buffalo model test battery evaluations.
Results: In the normal group, the highest correlation (0.648) was shown between the Decoding (D) component of the P-BMQ with the Row Staggered Spondaic Word (RSSW) variable. In the SLD group, the highest correlation (0.318) was shown between the Variance-tolerance fading memory (V) component of the P-BMQ and the qualitative Persian version of the Phonemic Sentence Test (P-PST) variable. The highest correlation was considered to be between the D component of the P-BMQ with the Right Competitive word, started in the Left ear (RC-LEF) variable in the SSW test (0.498), and qualitative P-PST variable (0.471); and 0.360 between the V component of the P-BMQ and Persian version of the Speech in Noise with S/N=4 in the Left ear (P-SIN4L) of variable in the P-SIN test.
Conclusion: P-BMQ is a useful screening tool complementing the Persian Buffalo model test battery for evaluating auditory processing evaluation in children.
Keywords: Central auditory processing disorder; specific learning disorder; Buffalo model questionnaire
A UTILIZAÇÃO DE PLANTAS MEDICINAIS PELOS IDOSOS HIPERTENSOS
Authors: Souza Érica Motta de , Favarin Mariane Rezin , Hoepers Neiva Junkes , Birollo Ioná Vieira Bez , Soratto Maria Tereza 
Published: December 2022

Objetivou-se, neste estudo, a identificação da forma com que são utilizadas as plantas medicinais pelos hipertensos participantes de um grupo de idoso. Participaram deste estudo 11 idosos hipertensos que utilizam algum tipo de planta medicinal. Trata-se de um estudo qualitativo, exploratório e descritivo, aplicou-se entrevista semi-estruturada. Os dados foram analisados por meio da técnica de análise de conteúdo, a partir da categorização proposta por Minayo. Os resultados apontaram que os idosos adquiriram informações e orientações sobre as plantas medicinais através da família, conhecimentos transmitidos de geração em geração, relatam conseguir as plantas medicinais no quintal de casa, com os vizinhos e parentes, colhem as plantas medicinais e já a utilizam. As Plantas Medicinais que utilizam para a Hipertensão são: chuchu; limão; berinjela; erva doce, camomila e cana cidreira, sendo que nem todas são indicadas para hipertensão. Todos os idosos relataram que não receberam orientações sobre a utilização de plantas medicinais, por profissionais de saúde. Logo, observou-se a falta de capacitação e busca pela qualificação dos profissionais acerca de assuntos que envolvem as plantas medicinais, tendo em vista que estas são muitas vezes utilizadas de forma inadequada devido à falta de informação.
Cultivation of <I>Brassica rapa</I> L. subsp. <I>nipposinica</I> plants at the multi circle hydroponic installation with help of natural immunomodulators
Authors: Balashova I. T. , Bondareva L. L. , Pinchuk E. V. , Molchanova A. V. , Shevchenko T. E. , Mashcenco N. E. 
Published: December 2022

Relevance. Modern vegetable production in greenhouses is based on high tech-advantageous, such as vertical hydroponic technology. Increasing of vertical hydroponic market is conditioned with ensuring the food security of states in conditions instability of food deliveries due to violations of traditional logistic connections. The program of vertical tomato hydroponics was developed and used in practice at the FSBSI FSVC in 2010-2020. Productivity potential of Brassica rapa L. subsp. nipposinica cultivated at vertical hydroponic installation have been studied in connection with the spread of consumption of fresh greens and “yellow-green” vegetables.The goal of the study was: the productivity characteristics and analysis of biochemical composition Brassica rapa L. subsp. nipposinica cultivated at the five-circle vertical hydroponic installation with help of natural immunomodulators.Materials and methods. Materials of study: seeds and leaves (rosette of leaves) from 2 varieties of Brassica rapa L. subsp. nipposinica – Japanese variety Salad Mizuna and new variety Salut Jubileiu (originated from FSBSI FSVC); immune modulators – flavonoid glycoside linarozide and steroid glycosides moldstim and trigonellozide.Methods. Seed treatment with 0,005%-water solutions of immune modulators; cultivation plants Brassica rapa L. subsp. nipposinica at the five-circle vertical hydroponic construction; analytical methods: determination of dry meter; determination the sum of antioxidants in leaves of Brassica rapa L. subsp. nipposinica; biometry; statistical methods: one-factorial dispersion analysis and two-factorial dispersion analysis.Results. Possibility of Brassica rapa L. subsp. nipposinica plants cultivation at multi circle hydroponic installations was established by authors. Seed treatment with water solutions of immune modulators wasn’t influence on seedlings appearing (the quality of seeds was very high -99-100%). Height of plant (of rosette) the variety Mizuna was increased as the reaction on the seed treatment, but the weight of plants wasn’t change. Salut Jubileiu variety reacted with increasing the common weight of plants. Number of leaves was increased. The content of dry matter in leaves didn’t change, but the sum content of antioxidants is rise significantly after seed treatment of immune modulators. The conclusion has been made: applying of immune modulators from glycosides class could to increase the productivity, vitamin value and safety cultivation of Brassica rapa L. subsp. nipposinica plants at multi circle hydroponics installation.
Abiotic stresses and ways to overcome them on <I>Achillea millefolium</I> L. in conditions of the Western Precaucasus
Authors: Tkhaganov R. R. , Morozov A. I. , Tropina N. S. , Tkhaganov R. N. 
Published: December 2022

Relevance. An important place in the extensive assortment of ether-oil cultures belongs to the common yarrow (Achillea millefolium L.), phytopreparations produced on its basis are widely used in the treatment of inflammatory processes, the normalization of the gastrointestinal tract.Methodology. To provide the pharmaceutical industry with this type of medicinal raw materials, it is necessary to create adapted technologies, where an important link will be the development of techniques for adapting the culture to unstable weather conditions.Results. The studies were carried out in the conditions of the North Caucasus branch of VILAR (West Ciscaucasia) in 2019-2021, by conducting small-scale experiments. The indicators of growth and development of yarrow of the II-V years of vegetation, the yield of raw materials, the content of essential oil and its collection per hectare under unstable weather conditions were studied. It was found that with sufficient moisture supply and a comfortable level of air temperatures in 2021, a high yield of medicinal raw materials of this crop is observed. At the same time, low water supply and high temperatures in 2020 had a negative impact on plant development, a drop in yield of 1.35-1.65 t/ha was established, which led to losses in the collection of essential oil per hectare by 3.23-4.32 kg/ha. A decrease in the degree of negative impact of drought on yarrow plants of the II-IV years of vegetation was achieved through the use of silicon-containing microfertilization Siliplant. Double treatment with this drug contributed to a decrease in the yield of raw materials to 5-6% and the collection of essential oil per hectare to 5-7%. in the control – 21-24% and 22-24%, respectively. Despite the high yield of raw materials in the III-III years of yarrow vegetation, the use of Siliplant allows collecting ether-oil raw materials for 4 years. Thus, the inclusion of Siliplant microfertilization in cultivation technology allows plants to adapt to hydrothermal stress conditions and makes it possible to obtain stable yields of raw materials with a high collection of essential oil per hectare, regardless of weather conditions.
Effect of ripening on biochemical characteristics of tangerine tomatoes (<I>Solanum lycopersicum</I> L.)
Authors: Kondratyeva I. Yu. , Molchanova A. V. 
Published: December 2022

Relevance. When creating tomato varieties and hybrids, much attention is paid not only to the commercial component (yield, appearance and uniform ripening), but also to the taste qualities of the products. Salad tomato varieties with yellow, tangerine, and pink fruits are increasingly in demand. As a rule, these fruits do not store for a long time, so it is necessary to increase their storability and transportability. Fruits of this group of tomatoes have high antioxidant activity, which is due not only to the significant content of water-soluble antioxidants (such as ascorbic acid), but also carotenoids. The preservation of fruit largely depends on the dry matter content.The aim of investigation is to study biochemical parameters of tangerine tomatoes fruits under different ripening conditions.Materials and methods. Plants were grown in the greenhouse of Federal Scientific Vegetable Center. Biochemical characteristics of tomato fruits were studied during harvesting and after laying for storage in the milky ripeness phase according to the following indicators: dry matter, ascorbic acid, total content of water-soluble antioxidants, titratable acidity, monosaccharides, polyphenols and carotenoids.Results. The percentage of dry matter in tangerine tomato fruits does not change during storage, even increases slightly. The dry matter content of fruits from the open field is slightly higher than that of fruits from the greenhouse. The content of sugars and ascorbic acid in fruits with tangerine fruits after laying for ripening decreases slightly. However, the content of these compounds is higher in mature fruits immediately after picking than in fruits after ripening. The total content of antioxidants during ripening decreases, though not significantly (in 1.1-1.7 times).
The effect of mulching materials on yield, biochemical composition and preservation of fruits of bell pepper
Authors: Yanchenko E. V. , Engalychev D. I. , Engalycheva N. A. , Alekseeva K. L. 
Published: December 2022

Introduction. The use of new covering materials is an important modern agrotechnique for cultivating of bell pepper in the open ground, which allows to minimize chemical treatments, increasing the yield, quality and preservation quality of vegetable products.The purpose of this work is to study the effect of various mulching materials (black polyethylene film and spandbond «Agrotex 60 perforated mulch») on the yield of bell pepper and also on biochemical composition of fruits and on their preservation quality in relation to the ripeness phase.Methods. The objects of the study were the fruits of two bell pepper hybrids of domestic and foreign breeding (respectively Nathalie F1 and Anetta F1), grown in the open ground using mulching materials. The experiments were laid according to standard methods adopted in vegetable growing. Storage was carried out in accordance with the methodological guidelines for conducting research on the storage of vegetables.Results. The use of mulching materials contributed to an increase in total yield and the yield of standard products in the crop structure, and also positively affected the accumulation of solids, vitamin C, monosaccharides, disaccharides and as a whole – the sum of sugars. The domestic hybrid Natalie F1 (74.9%), grown using black film as a mulching material, as compared to foreign hybrid Anetta F1 (71.3%), was characterized by better preservation quality. Significant differences in the chemical composition of fruits depending on the ripeness phase were revealed. Fruits laid for storage in full biological ripeness (red) were characterized by an increased amount of weight loss on all storage options. A positive effect on the storage persistence of bell pepper fruits with use of mulching materials on all variants of the experiment was also established.
The use of Language In International Agreements According to The 1969 Vienna Convention And Its Implementation In Indonesian National Law
Authors: Elvardi Jean , Hasan Firman , Pratama Arya Putra Rizal 
Published: December 2022

The use of language in international agreements is very important to establish international cooperation. It is also noteworthy that according to the Indonesian law, the international agreements related to several matters adopted by the government shall be translated to Bahasa Indonesia. However, the terms contained in Indonesian national law, in Bahasa Indonesia, often tend to be different from the meanings contained in international law, such as the 1969 Vienna Convention on the Law of Treaties. Thus, they often have multiple interpretations. As such, the use of language, especially relating to international agreements, can be a trigger for legal disputes. In this regard, using a legal research method by analyzing the international legal instruments and Indonesian national law, this paper digs into the use of language related to the adoption of an international agreement to an Indonesian Law, especially regarding the terms of “ratification,” “accession,” and others. It is argued that there is a difference of perspective within the “adoption of an international agreement” regarding the terms of “ratification” and “accession” under the 1969 Vienna Convention.
Fake Accounts on Social Media as a Criminal Act of Electronic Information Manipulation in Indonesia
Authors: Rezky Michelle , Ibrahim Aji Lukman 
Published: December 2022

There are often cases where irresponsible individuals create social media accounts using other people's personal identities as if the account is the original account of the person whose identity is being used, hereinafter referred to as fake social media accounts. Such actions can be threatened with Article 35 jo. Article 51 paragraph (1) of Law Number 11 of 2008 concerning Information and Electronic Transactions (ITE Law). The type of research used by the author in this study is prescriptive normative law research with a statute approach and a case approach. In Verdict Number 1739/Pid.Sus/2020/PN Jkt.Brt, the defendant was declared guilty of committing a crime under Article 28 paragraph (1) jo. Article 45A paragraph (1) ITE Law. Not only fulfilling the elements in Article 28 paragraph (1) of the ITE Law, but the defendant also fulfilled the elements in Article 35 of the ITE Law. However, the defendant was not found guilty of a criminal offense under Article 35 of the ITE Law, even though Article 35 of the ITE Law was one of the prosecutor's indictments. Based on this research, the defendant was not found guilty of a criminal offense under Article 35 of the ITE Law because the form of the indictment in Verdict Number 1739/Pid.Sus/2020/PN Jkt.Brt is less precise. The form of indictment used by the public prosecutor is an Alternative Indictment where ideally the public prosecutor ought to use Cumulative Indictment on a concursus realis crime that the defendant committed.