bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Pilot Study of the Effects of Ajwa Date Seed Extract in a Diabetic Animal with Parallel Observations on Human Subjects
Authors: Felemban Shifa , Hamouda Asmaa Fathi 
Published: May 2022

Background: most diseases are inequality of the antioxidants, pro-oxidants, and failure in resolved inflammation. Diabetes is a metabolic malfunction associated with inflammation and ends with organs failure. Alternative treatments for diabetes include a lifestyle and an anti-inflammatory diet.
Method: we investigated the effects of dietary Ajwa dates seeds extract (AJSO) against alloxan monohydrate-induced biochemical changes. We analyzed the phytochemical components of AJSO with gas chromatography-mass spectrometry and inductively coupled plasma-mass spectrometry. We determined the effects of oral AJSO on biochemical changes caused by alloxan monohydrate in rats. We also observed biochemical changes in human volunteers with or without Ajwa seed as caffeine-free coffee replacements.
Results: the results and outcomes confirmed the improvement in the rats’ biochemical analysis due to AJSO constituents. The treatment of AJSO after alloxan monohydrate injection significantly (p ≤ 0.05) decline the studied parameters NO, MDA, Amyloid A, CRP, and glucose concentrations by 47.2%, 34.8%, 55.6%, 47.4%and 60.0%, respectively, compared to treatment only with alloxan monohydrate. The volunteers treated with Ajwa seed as caffeine-free coffee replacements(group2) showed significant amelioration of inflammatory and diabetes markers as compared to the untreated group1. Group 2 showed a significant decrease in the concentration of serum NO (34.7%), MDA (43.9%), amyloid A (79.6%), CRP (60.9%), HbA1c (33.8%), Troponin T (16.4%), serum total cholesterol (14.2 %), TG (28.1%), LDL-C (6.1%), AST 8.8%, and ALT (11.6%) compared to Group1.
Conclusion: AJSO had a healthy impact by decreasing the levels of amyloid a, c-reactive protein, lipid peroxidation, nitric oxide, and improving diabetes, lipid and liver profiles in both rats and human volunteers. Further long-term investigation of higher numbers and the different types and sexes is needed in progress to confirm and validate the results.
Evaluation of QA software system analysis for the static picket fence test
Authors: Boudet Julien , Aubignac Léone , Beneux Amandine , Mazoyer Frédéric , Bessieres Igor 
Published: May 2022

AbstractIntensity modulation treatments are widely used in radiotherapy because of many known advantages. In this context, the picket fence test (PF) is a relevant test to check the Multileaf Collimator (MLC) performances. So this work compares and evaluates three analysis platforms for the PF used routinely by three different institutions. This study covers two linear accelerators (Linac) with two MLC types, a Millenium 120 MLC and Millenium 120 High Definition MLC respectively on a Varian Truebeam and Truebeam STx. Both linacs include an As 1200 portal imager (EPID). From a reference PF plan, MLC errors have been introduced to modify the slits in position or width (shifts from 0.1 to 0.5 mm on one or both banks). Then errors have been defined on the EPID to investigate detection system deviations (signal sensitivity and position variations). Finally, 110 DICOM‐RT images have been generated and analyzed by each software system. All software systems have shown good performances to quantify the position errors, even though the leaf pair identifications can be wrong in some cases regarding the analysis method considered. The slit width measurement (not calculated by all software systems) has shown good sensitivity, but some quantification difficulties have been highlighted regardless of the analysis method used. Linked to the expected accuracy of the PF test, the imager variations have demonstrated considerable influence in the results. Differences in the results and the analysis methods have been pointed out for each software system. The results can be helpful to optimize the settings of each analysis software system depending on expectations and treatment modalities of each institution.
Finger pointing to self‐manage cognitive load in learning from split‐attention examples
Authors: Zhang Shirong , de Koning Bjorn B. , Paas Fred 
Published: May 2022

AbstractWe investigated whether finger pointing can be used as a cognitive load self‐management strategy when learning from split‐attention examples. We expected that pointing would reduce cognitive load and enhance learning performance. In a guided self‐management phase, 122 university students studied a split‐attention example under three pointing conditions (i.e., no pointing, one‐handed pointing, two‐handed pointing) or an integrated example without pointing. In the subsequent unguided self‐management phase, all students studied a new split‐attention example without pointing instructions. Results on retention and comprehension tests and self‐ratings of cognitive load after studying each split‐attention example revealed no differences between conditions. An exploratory analysis of pointing movements in the unguided self‐management phase revealed that participants who frequently pointed outperformed those who barely pointed on the comprehension test in this phase. Our findings provide some suggestive evidence for the effectiveness of pointing as a self‐management strategy in the learning from split‐attention examples.
Constructing Highly Conductive and Thermomechanical Stable Quasi‐Solid Electrolytes by Self‐Polymerization of Liquid Electrolytes within Porous Polyimide Nanofiber Films
Authors: Huang Yue , Liu Shujie , Chen Qiaojing , Jiao Kejin , Ding Bin , Yan Jianhua 
Published: May 2022

AbstractSolid electrolytes are being considered as an effective solution to replace liquid ones for building safer batteries, but they suffer either low ionic conductivity or large contact ohmic impedance. Here, a highly conductive and thermomechanically stable quasi‐solid electrolytes (QSE) by self‐polymerization of a commercially available liquid electrolytes (1,3‐dioxolane (DOL), 1,2‐dimethoxyethane (DME), lithium trifluoromethane sulfonimide (LiTFSI) and LiPF6) at room temperature in a porous polyimide nanofiber film are reported. LiPF6 initiates the ring‐opening reaction of DOL and LiTFSI promotes the self‐polymerization to form poly‐DOL (PDOL), while the plasticizer of DME solidifies the PDOL. On the other hand, polyimide has a great affinity with PDOL that facilitates to form stable QSE network. As a result, the QSE film shows a high room‐temperature ionic conductivity of 2.9 × 10−3 S cm−1, a high mechanical strength of 31 MPa, and high heat resistance to 160 °C. The LiFePO4||QSE||Li batteries with a high cathode loading of ≈18.7 mg cm−2 show great cycling performance and stable electrode/electrolyte interfaces at a high current rate of 0.5 C with a capacity retention of 91.8% over 200 cycles at room temperature.
Graphene Membranes for Multi‐Dimensional Electron Microscopy Imaging: Preparation, Application, and Prospect
Authors: Gao Xiaoyin , Zheng Liming , Yao Yating , Peng Hailin 
Published: May 2022

AbstractTechnological breakthrough in electron microscopy (EM) has started a resolution revolution in EM imaging. Nowadays, the promotion of resolution demands a robust background‐noise‐free EM support for specimen preparation, which is a primary bottleneck of high‐resolution EM imaging. Owing to the atomic thickness and excellent physical properties, graphene has attracted widespread attention in the EM field to achieve high‐resolution multi‐dimensional imaging. However, it is still challenging to prepare high‐quality suspended graphene membranes. Problems like breakage, contamination and wrinkling reduce the quality of suspended graphene membranes, which inhibit their wide and killer applications in EM imaging. In this review, suspended graphene membranes are looked deeply into for multi‐dimensional EM imaging. This study begins with a brief introduction to EM development, followed by a discussion of the synthesis of high‐quality graphene. Then it summarizes various approaches to produce suspended graphene membranes and their killer applications in multi‐dimensional EM characterization, including high‐resolution 2D imaging, cryo‐EM 3D reconstruction, and 4D in situ liquid EM. Based on current achievements, the prospects of graphene membranes for more cutting‐edge applications are finally proposed.
In Situ Anchoring Massive Isolated Pt Atoms at Cationic Vacancies of α‐NixFe1‐x(OH)2 to Regulate the Electronic Structure for Overall Water Splitting
Authors: Wang Liming , Zhang Lili , Ma Wei , Wan Hao , Zhang Xinjie , Zhang Xu , Jiang Suyu , Zheng Jin You , Zhou Zhen 
Published: May 2022

AbstractRational design and preparation of single‐atom catalysts provide a promising strategy to significantly improve the electrocatalytic activity for water splitting. In particular, single atoms anchored at cationic vacancies can enhance the stability of the catalysts and improve reaction kinetics. In this work, Pt single atoms are loaded at layered α‐Ni2/3Fe1/3(OH)2 by oxidizing Fe2+ with H2PtCl6, and specifically, Pt atoms are anchored at in situ generated iron cationic vacancies during the process, resulting in stabilized Pt single atoms in the surface of α‐Ni2/3Fe1/3(OH)2 with the maximum loading of ≈6.15 wt%. The Pt single atoms not only act as active sites for hydrogen evolution reaction but also regulate the electronic structure of NiFe hydroxides and activate Ni atoms adjacent to Pt for oxygen evolution reaction. Therefore, the water‐splitting electrolyzer assembled with such a bifunctional catalyst shows a smaller overpotential than that with RuO2 and 20 wt% Pt/C catalysts as the anode and cathode, respectively, and efficient solar‐to‐hydrogen conversion. The results demonstrate the practical application of single‐atom Pt catalysts with low cost, large loading, and facile preparation route.
High‐Temperature Flexible Nanocomposites with Ultra‐High Energy Storage Density by Nanostructured MgO Fillers
Authors: Wang Pengjian , Guo Yan , Zhou Di , Li Da , Pang Lixia , Liu Wenfeng , Su Jinzhan , Shi Zhongqi , Sun Shikuan 
Published: May 2022

AbstractHigh‐temperature performance is critical to the dielectric polymer capacitors used in environment electronic and high‐power applications. Here, the authors report a composite comprising polyimide (PI) dielectric polymers blended with high‐insulation magnesium oxide (MgO) nano‐filler that exhibits high breakdown strength, wide temperature range, and low dielectric loss. However, most dielectric polymers possess excellent energy storage properties at room temperature and cannot be used at high temperatures above 100 °C. Polyimide dielectric nanocomposites prepared by in situ polymerization, which are composed of easily prepared MgO fillers, have different morphologies, such as nanoparticles (0D), nanowires (1D), and nanoplates (2D). The experimental results show that the insulation behavior and breakdown strength of polymer composites are closely related to the morphology of MgO fillers, and the rationality of this conclusion is further proved by finite‐element simulation results. The polymer composites containing ultra‐low content (0.5 vol%) MgO nanosheets produce an ultra‐high capacitance performance, that is, the discharge energy density is 4.78 J cm−3 at 150 °C, which is significantly better than the most reported dielectric polymers and nanocomposites.
Protein‐Mimicking Nanoparticles in Biosystems
Authors: Ji Xiaoyuan , Li Qian , Song Haiyun , Fan Chunhai 
Published: May 2022

AbstractProteins are essential elements for almost all life activities. The emergence of nanotechnology offers innovative strategies to create a diversity of nanoparticles (NPs) with intrinsic capacities of mimicking the functions of proteins. These artificial mimics are produced in a cost‐efficient and controllable manner, with their protein‐mimicking performances comparable or superior to those of natural proteins. Moreover, they can be endowed with additional functionalities that are absent in natural proteins, such as cargo loading, active targeting, membrane penetrating, and multistimuli responding. Therefore, protein‐mimicking NPs have been utilized more and more often in biosystems for a wide range of applications including detection, imaging, diagnosis, and therapy. To highlight recent progress in this broad field, herein, representative protein‐mimicking NPs that fall into one of the four distinct categories are summarized: mimics of enzymes (nanozymes), mimics of fluorescent proteins, NPs with high affinity binding to specific proteins or DNA sequences, and mimics of protein scaffolds. This review covers their subclassifications, characteristic features, functioning mechanisms, as well as the extensive exploitation of their great potential for biological and biomedical purposes. Finally, the challenges and prospects in future development of protein‐mimicking NPs are discussed.
Ultrasoft Porous 3D Conductive Dry Electrodes for Electrophysiological Sensing and Myoelectric Control
Authors: Yao Shanshan , Zhou Weixin , Hinson Robert , Dong Penghao , Wu Shuang , Ives Jasmine , Hu Xiaogang , Huang He , Zhu Yong 
Published: May 2022

AbstractBiopotential electrodes have found broad applications in health monitoring, human–machine interactions, and rehabilitation. This article reports the fabrication and applications of ultrasoft breathable dry electrodes that can address several challenges for their long‐term wearable applications—skin compatibility, wearability, and long‐term stability. The proposed electrodes rely on porous and conductive silver nanowire‐based nanocomposites as the robust mechanical and electrical interface. The highly conductive and conformable structure eliminates the necessity of conductive gel while establishing a sufficiently low electrode–skin impedance for high‐fidelity electrophysiological sensing. The introduction of gas‐permeable structures via a simple and scalable method based on sacrificial templates improves breathability and skin compatibility for applications requiring long‐term skin contact. Such conformable and breathable dry electrodes allow for efficient and unobtrusive monitoring of heart, muscle, and brain activities. In addition, based on the muscle activities captured by the electrodes and a musculoskeletal model, electromyogram‐based neural–machine interfaces are realized, illustrating the great potential for prosthesis control, neurorehabilitation, and virtual reality.
A Biodegradable Hybrid Micro/Nano Conductive Zinc Paste for Paper‐Based Flexible Bioelectronics
Authors: Zareei Amin , Selvamani Vidhya , Gopalakrishnan Sarath , Kadian Sachin , Maruthamuthu Murali Kannan , He Zihao , Nguyen Juliane , Wang Haiyan , Rahimi Rahim 
Published: May 2022

AbstractPaper‐based electronics are emerging as a new class of technology with broad areas of application. Despite several efforts to fabricate new types of flexible electronic devices by screen printing of conductive paste, many of them are often nonbiodegradable, toxic, and expensive, limiting their practical use in bioresorbable paper‐based electronics. To address this need, a highly conductive and biodegradable bimodal conductive paste is developed using cost‐effective zinc‐based micro and nanoparticles with a facile low‐temperature sintering process compatible with paper substrates. The two‐step sintering process involves the removal of the insulating zinc oxide layer by spray coating acetic acid followed by a heat press sintering process to ensure the formation of highly packed and continuous metallic traces. The required conditions for the heat press sintering process are systematically studied using electrical, optical, and mechanical characterization techniques. The results of these investigations revealed an ultra‐packed microstructure with high electrical conductivity (0.5 × 105 S m−1) and low oxide content that is obtained with a heat press sintering setting of 220 °C for 60 s. Finally, as a proof of concept, the conductive paste with an optimized sintering process is used to fabricate a wearable wireless heater for remote‐controlled release of therapeutics. The controlled delivery of the system is validated in the practical and on‐demand delivery of antibiotics for eradicating commonly found bacteria such as Staphylococcus aureus in dermal wound infections. The biocompatibility of all the materials and manufacturing process is validated by NIH/3T3 fibroblast cells via MTT assay and live/dead staining.
Immobilized Molecules’ Impact on the Efficacy of Nanocarbon Organic Sensors for Ultralow Dopamine Detection in Biofluids
Authors: Suriyaprakash Jagadeesh , Gupta Neeraj , Shan Lianwei , Wu Lijun 
Published: May 2022

AbstractDopamine (DA) is a key neurotransmitter that regulates many behaviors and physical functions in the human body. Therefore, there is a significant technological demand for an affordable point‐of‐care (POC) device to monitor low DA levels up to 10−12min human biofluids. This can be achieved if the underlying interaction mechanism of analyte– materials–transduction is tuned at the molecular level in the carbon‐based organic sensors, and such knowledge is deficient in current literature. Herein, the one‐step facile molecular engineering approach is adopted to develop three organic‐based sensors consisting of different arylamines (hydroxyl/carboxyl/sulfonate) anchored to the surface of 2D‐reduced graphene oxide (rGO). The impact of immobilized molecules on their efficacy is studied in detail by experimental and computational approaches. The carboxyl–arylamine attached to rGO surface outperforms others, resulting in the detection of DA up to 10 × 10−12m(at a larger linear range of 10−10–10−4m) in the presence of interferents. As a proof of concept, a POC device is designed and evaluated in serum, artificial sweat, and urine samples, exhibiting exceptional results. The rational understanding and fundamental science behind the tunable features of carbon‐based organic sensors presented in this work will enable the development of innovative probes for detecting neurotransmitters and related biomolecules.
Na‐Ion Battery with Graphite Anode and Na3V2(PO4)3 Cathode via Solvent‐Co‐Intercalation Process
Authors: Subramanyan Krishnan , Akshay Manohar , Lee Yun‐Sung , Aravindan Vanchiappan 
Published: May 2022

AbstractSpent Li‐ion batteries are efficiently recycled by extracting and reusing the anode active material, graphite, through a simple yet effective and scalable technique as anode for the sodium‐ion battery (SIB). The recovered graphite (RG) half‐cell rendered a capacity of >120 mAh g−1 via the solvent‐co‐intercalation process. An in situ impedance is performed to assess the robustness of the electrolyte for the extended cycling. The performance of RG is evaluated in a full‐cell with carbon‐coated Na3V2(PO4)3 cathode, which exhibits capacity retention of 78% after 100 cycles. In addition, a temperature dependence performance of the full‐cell is studied from −10 to 40 °C, where it exhibits outstanding low‐temperature performance. The full‐cell provides an energy density of 78 Wh kg−1 at ambient temperature conditions. Recovery of active materials for SIB will drive down the cost/kWh and act as a green technology to dispose of spent Li‐ion batteries.
Dynamic Interplay between Structural Variations and 3D Genome Organization in Pancreatic Cancer
Authors: Du Yongxing , Gu Zongting , Li Zongze , Yuan Zan , Zhao Yue , Zheng Xiaohao , Bo Xiaochen , Chen Hebing , Wang Chengfeng 
Published: May 2022

AbstractStructural variations (SVs) are the greatest source of variations in the genome and can lead to oncogenesis. However, the identification and interpretation of SVs in human cancer remain technologically challenging. Here, long‐read sequencing is first employed to depict the signatures of structural variations in carcinogenesis of human pancreatic ductal epithelium. Then widespread reprogramming of the 3D chromatin architecture is revealed by an in situ Hi‐C technique. Integrative analyses indicate that the distribution pattern of SVs among the 3D genome is highly cell‐type specific and the bulk remodeling effects of SVs in the chromatin organization partly depend on intercellular genomic heterogeneity. Meanwhile, contact domains tend to minimize these disrupting effects of SVs within local adjacent genomic regions to maintain overall stability. Notably, complex genomic rearrangements involving two key driver genes CDKN2A and SMAD4 are identified, and their influence on the expression of oncogenes MIR31HG, MYO5B, etc., are further elucidated from both a linear view and 3D perspective. Overall, this work provides a genome‐wide resource and highlights the impact, complexity, and dynamicity of the interplay between structural variations and high‐order chromatin organization, which expands the current understanding of the pathogenesis of SVs in human cancer.
Soil health within transitions from irrigation to limited irrigation and dryland management
Authors: Bhandari Krishna B. , Acosta‐Martínez Veronica , Pérez‐Guzmán Lumarie , West Charles P. 
Published: May 2022

AbstractThe decline in groundwater supply in the Texas High Plains is forcing some growers to convert center‐pivot irrigated cropland to dryland production. Transitioning toward reduced water input can lead to declines in soil health. We assessed short‐term changes in soil health indicators in two transition scenarios: (a) from high irrigation method to low irrigation method (center pivot to subsurface drip) and (b) from high irrigation method to dryland (center pivot to dryland), in comparison to continuous center‐pivot management. We monitored changes in chemical and biological indicators in four fields for each transition scenario and in three pivot‐irrigated fields. There were declines in soil water content, potassium (K), sodium (Na), and soil organic carbon with transition from irrigation to reduced irrigation and dryland. Severe drought in the final year revealed reduced amounts of multi‐enzyme activities, total ester‐linked fatty acid methyl ester (EL‐FAME), and total fungi. Transitioning to low water‐input management in this environment complicates efforts to maintain microbial components of soil health. Longer‐term comparisons are needed to detect slow changes in soil health indicators on producers’ fields.
Boosted Charge‐Carrier Transport in Triple‐Cation Perovskites by Ultrasonic Vibration Post Treatment
Authors: Wang Yuzhuo , Ahmadian‐Yazdi Mohammad‐Reza , Ni Yangyang , Jiang Yexin , Eslamian Morteza , Jin Zuanming , Chen Qianli 
Published: May 2022

AbstractUltrasonic vibration imposed on the substrate of a drying perovskite solution film has previously been proposed as a nearly annealing‐free method to improve film quality and thus the photovoltaic performance for perovskite solar cells. However, an in‐depth understanding of the underlying mechanism of the improved film quality via ultrasonic vibration is still lacking. In this work, the effects of substrate vibration post treatment on the carrier lifetime and mobility are studied in triple‐cation perovskite films. With 80 s of annealing‐free vibration, the perovskite film demonstrates much stronger photoluminescence intensity and much longer carrier lifetime up to 2.634 µs, 2 orders of magnitude longer than that of the thermal annealed films. Optical pump terahertz probe spectroscopy reveals that the charge‐carrier mobility increases to 121 ± 44 cm2 V−1 s−1 when subjected to 80 s vibration followed by annealing. Such mobility is about 80 ± 40 cm2 V−1 s−1 higher than that of other polycrystalline organic–inorganic hybrid perovskite thin films of similar composition. The diffusion length is improved to nearly 1.5 times. The new understanding on the vibration‐induced charge‐carrier transport properties paves the way for the application of ultrasonic vibration toward the performance improvement of perovskite‐based electronic devices.