bluuebunny/crossref_metadata_2025_split huggingface dataset:
Single-nucleotide polymorphisms and the effectiveness of taxane-based chemotherapy in premenopausal breast cancer: a population-based cohort study in Denmark
Authors: Hjorth Cathrine F. , Damkier Per , Stage Tore B. , Feddersen Søren , Hamilton-Dutoit Stephen , Rørth Mikael , Ejlertsen Bent , Lash Timothy L. , Ahern Thomas P. , Sørensen Henrik T. , Cronin-Fenton Deirdre 
Published: May 2022

Abstract
Purpose
Taxane-based chemotherapy is the primary treatment for premenopausal breast cancer. Although being inconsistent, research suggests that variant alleles alter pharmacokinetics through reduced function of OATP transporters (limiting hepatic uptake), CYP-450 enzymes (hampering drug metabolism), and ABC transporters (decreasing clearance). Reduced function of DNA repair enzymes may hamper effectiveness through dose-limiting toxicities. We investigated whether single-nucleotide polymorphisms (SNPs) were associated with breast cancer recurrence or mortality in premenopausal women diagnosed with breast cancer.

Methods
We conducted a population-based cohort study of premenopausal women diagnosed with non-distant metastatic breast cancer in Denmark during 2007‒2011, when guidelines recommended adjuvant combination chemotherapy (taxanes, anthracyclines, and cyclophosphamide). Using archived formalin-fixed paraffin-embedded primary tumor tissue, we genotyped 26 SNPs using TaqMan assays. Danish health registries provided data on breast cancer recurrence (through September 25, 2017) and death (through December 31, 2019). We fit Cox regression models to calculate crude hazard ratios (HRs) and 95% confidence intervals (CIs) for recurrence and mortality across genotypes.

Results
Among 2,262 women, 249 experienced recurrence (cumulative incidence: 13%) and 259 died (cumulative incidence: 16%) during follow-up (median 7.0 and 10.1 years, respectively). Mortality was increased in variant carriers of GSTP1 rs1138272 (HR: 1.30, 95% CI 0.95–1.78) and CYP3A rs10273424 (HR: 1.33, 95% CI 0.98–1.81). SLCO1B1 rs2306283 (encoding OATP1B1) variant carriers had decreased recurrence (HR: 0.82, 95% CI 0.64–1.07) and mortality (HR: 0.77, 95% CI 0.60–0.98).

Conclusion
Docetaxel effectiveness was influenced by SNPs in GSTP1, CYP3A, and SLCO1B1 in premenopausal women with non-distant metastatic breast cancer, likely related to altered docetaxel pharmacokinetics. These SNPs may help determine individual benefit from taxane-based chemotherapy.
BBoxDB streams: scalable processing of multi-dimensional data streams
Authors: Nidzwetzki Jan Kristof , Güting Ralf Hartmut 
Published: May 2022

AbstractBBoxDB Streams is a distributed stream processing system, which allows the handling of multi-dimensional data. Multi-dimensional streams consist of n-dimensional elements, such as position data (e.g., two-dimensional positions of cars or three-dimensional positions of aircraft). The software is an enhancement of BBoxDB, a distributed key-bounding-box-value store that allows the handling of n-dimensional big data. BBoxDB Streams supports continuous range queries and continuous spatial joins; n-dimensional point and non-point data are supported. Operations in BBoxDB Streams are performed primarily on the bounding boxes of the data. With user-defined filters (UDFs), custom data formats can be decoded, and the bounding box-based operations are refined (e.g., a UDF decodes and performs intersection tests on the real geometries of WKT encoded stream elements). A unique feature of BBoxDB Streams is the ability to perform continuous spatial joins between stream elements and previously stored multi-dimensional big data. For example, the dynamic position of a car can be efficiently joined with the static spatial data of a street network.
A bibliometric analysis of circular economy in the fields of business and economics: towards more action-oriented research
Authors: Dominko Miha , Primc Kaja , Slabe-Erker Renata , Kalar Barbara 
Published: May 2022

AbstractIn this paper, we reveal and systemize development trends in the scientific field of the circular economy (CE). Our results imply that academic research on the CE focuses heavily on theoretical conceptualizations and technological solutions. However, these advancements alone are unlikely to help prevent from ecological collapse. With this observation in mind, we explore the potential held by a more relational, action-based approach to support a faster and more efficient transition from the linear economy to the CE. A useful combination of several bibliometric techniques gave us valuable references for re-focusing this area of science to adopt action-oriented research where a group of stakeholders collaborates and co-creates solutions. An analysis of valuable action-oriented CE studies reveals that scholars focus on the techno-economic aspect, where they develop ways to create optimal circular material and energy flows and co-design processes for products/services, as well as the organizational aspect, where they study self-sustainable community networks and participatory governance. We identify three research streams that would benefit from such action-oriented research for a faster practical implementation: sustainable supply chains, waste management, and business model innovation. A practice-based agenda is proposed to stimulate the scientific community to conduct future research on a CE that better supports companies.
Consequences of COVID-19 on the Reindeer Husbandry in Norway: a Pilot Study Among Management Staff and Herders
Authors: Fisktjønmo Guro Lovise Hole , Næss Marius Warg 
Published: May 2022

AbstractThe outbreak of COVID-19 has had an enormous impact on most of society. The most effective measure to prevent the spread has been reducing mobility, which is especially problematic for pastoralists relying on mobility to follow the movement of their livestock. We investigated to what degree Norwegian reindeer husbandry and the reindeer husbandry management system are affected by COVID-19 and government restrictions to mitigate the effects of the pandemic. For reindeer herders, our main finding was that the COVID-19 had little to no impact on their daily work. However, impacts varied by domain, with work in corrals, income, and slaughter being negatively affected. For employees in the management system, communication/contact with herders and visits/control of corrals/slaughter have been negatively affected. Employees in the management system were satisfied with how information concerning COVID-19 and prevention measures have been communicated by the central government, while the herders were mainly dissatisfied.
Chlorophyta microalgae as dietary protein supplement: a comparative analysis of productivity related to photosynthesis
Authors: Baldisserotto Costanza , Sabia Alessandra , Giovanardi Martina , Ferroni Lorenzo , Maglie Michele , Pancaldi Simonetta 
Published: May 2022

AbstractMicroalgae are studied as innovative sources of a wide range of highly valuable products, including proteins for the food/feed sectors. However, protein content varies depending on algal species, culture conditions and harvesting period. The Phylum Chlorophyta includes most of the described species of green algae. Due to their remarkable peculiarities, four Chlorophyta species belonging to two distinct classes were selected for the research: Chlorella vulgaris and Chlorella protothecoides as Trebouxiophyceae, and Neochloris oleoabundans and Scenedesmus acutus as Chlorophyceae. The algae were studied to obtain comparative results about their growth performance, and total protein content and profile under the same culture conditions. Since photosynthetic process directly influences biomass production, photosynthetic pigment, PSII maximum quantum yield and thylakoid protein content and profile were analysed. SDS-PAGE and 2D BN/SDS-PAGE were performed to expand information on the organization and assembly of the resolved thylakoid complexes of samples. Despite the algal species showed similar growth rates and photosynthetic efficiency, S. acutus showed the highest capability to accumulate proteins and photosynthetic pigments. Regarding the thylakoid protein profile, the two Trebouxiophyceae showed very similar pattern, whereas different amounts of LHCII occurred within the two Chlorophyceae. Finally, the separation of thylakoid protein complexes in 2D BN/SDS-PAGE revealed a more complex pattern in S. acutus as compared to the other species. Overall, it is suggested that a higher stability of the photosynthetic membranes can result in higher biomass and protein production. Altogether, results have highlighted the metabolic uniqueness of each strain, resulting in a non-obvious comparison with the other species.
Mammalian cumulus-oocyte complex communication: a dialog through long and short distance messaging
Authors: Marchais Mathilde , Gilbert Isabelle , Bastien Alexandre , Macaulay Angus , Robert Claude 
Published: May 2022

Abstract
Communications are crucial to ovarian follicle development and to ovulation, and while both folliculogenesis and oogenesis are distinct processes, they share highly interdependent signaling pathways. Signals from distant organs such as the brain must be processed and compartments within the follicle have to be synchronized. The hypothalamic–pituitary–gonadal (HPG) axis relies on long-distance signalling analogous to wireless communication by which data is disseminated in the environment and cells equipped with the appropriate receptors receive and interpret the messages. In contrast, direct cell-to-cell transfer of molecules is a very targeted, short distance messaging system. Numerous signalling pathways have been identified and proven to be essential for the production of a developmentally competent egg. The development of the cumulus-oocyte complex relies largely on short distance communications or direct transfer type via extensions of corona radiata cells through the zona pellucida. The type of information transmitted through these transzonal projections is still largely uncharacterized. This review provides an overview of current understanding of the mechanisms by which the gamete receives and transmits information within the follicle. Moreover, it highlights the fact that in addition to the well-known systemic long-distance based communications from the HPG axis, these mechanisms acting more locally should also be considered as important targets for controlling/optimizing oocyte quality.
Applications of Order Trees in Infinite Graphs
Authors: Pitz Max 
Published: May 2022

AbstractTraditionally, the trees studied in infinite graphs are trees of height at most ω, with each node adjacent to its parent and its children (and every branch of the tree inducing a path or a ray). However, there is also a method, systematically introduced by Brochet and Diestel, of turning arbitrary well-founded order trees T into graphs, in a way such that every T-branch induces a generalised path in the sense of Rado. This article contains an introduction to this method and then surveys four recent applications of order trees to infinite graphs, with relevance for well-quasi orderings, Hadwiger’s conjecture, normal spanning trees and end-structure, the last two addressing long-standing open problems by Halin.
Psychiatric Comorbidities of Substance Use Disorders: Does Dual Diagnosis Predict Inpatient Detoxification Treatment Outcomes?
Authors: Davis Adrian , McMaster Patrick , Christie Daniel C. , Yang Anes , Kruk Jeffrey S. , Fisher Karen A. 
Published: May 2022

AbstractComorbidity of substance use and psychiatric disorders, particularly depressive disorders, are well established. The impact of comorbidity on treatment outcomes, particularly following short-term inpatient detoxification and medical management units, has yet to be fully explored. This study reviewed 456 records of patients voluntarily presenting for medical management of substance misuse in Sydney, Australia. Documented psychiatric comorbidities and primary substance of misuse were extracted and used to predict length of stay, discharge against medical advice and number of readmissions. Our results showed that psychiatric comorbidity did not significantly predict treatment outcomes, although depression was reported in more than half our cohort, along with elevated rates of Post-traumatic Stress Disorder, anxiety disorders and bipolar affective disorders. Medication non-compliance and primary substance of misuse significantly predicted length of stay and discharge against medical advice. Further research into how specific substances interact and affect specific psychiatric disorders is needed to guide optimal treatment options.
Development and Application of Landsat-Based Wetland Vegetation Cover and UnVegetated-Vegetated Marsh Ratio (UVVR) for the Conterminous United States
Authors: Ganju Neil K. , Couvillion Brady R. , Defne Zafer , Ackerman Katherine V. 
Published: May 2022

AbstractEffective management and restoration of salt marshes and other vegetated intertidal habitats require objective and spatially integrated metrics of geomorphic status and vulnerability. The unvegetated-vegetated marsh ratio (UVVR), a recently developed metric, can be used to establish present-day vegetative cover, identify stability thresholds, and quantify vulnerability to open-water conversion over a range of spatial scales. We developed a Landsat-based approach to quantify the within-pixel vegetated fraction and UVVR for coastal wetlands of the conterminous United States, at 30-m resolution for 2014–2018. Here we present the methodology used to generate the UVVR from spectral indices, along with calibration, validation, and spatial autocorrelation assessments. We then demonstrate multiple applications of the data across varying spatial scales: first, we aggregate the UVVR across individual states and estuaries to quantify total vegetated wetland area for the nation. On the state level, Louisiana and Florida account for over 50% of the nation’s total, while on the estuarine level, the Chesapeake Bay Estuary and selected Louisiana coastal areas each account for over 6% of the nation’s total vegetated wetland area. Second, we present cases where this dataset can be used to track wetland change (e.g., expansion due to restoration and loss due to stressors). Lastly, we propose a classification methodology that delineates areas vulnerable to open-water expansion based on the 5-year mean and standard deviation of the UVVR. Calculating the UVVR for the period-of-record back to 1985, as well as regular updating, will fill a critical gap for tracking national status of salt marshes and other vegetated habitats through time and space.
Migrationsbeiräte und demokratische Regression? Akteure, Konflikte und Repräsentation im Vergleich
Authors: Kersting Norbert , Budnik Maria , Haase Annegret , Hedtke Christoph , Krahmer Alexander 
Published: May 2022

ZusammenfassungHessen und Nordrhein-Westfalen nahmen nach langen Auseinandersetzungen in vielen Kommunen in den 1990ern die Ausländerbeiräte bzw. Integrationsräte als Repräsentationsgremium der Menschen mit Migrationshintergrund in ihre Gemeindeordnungen auf. Diese fokussierten auf Selbstbestimmung und relativ unabhängige Beiratsstrukturen mit einer Urwahl der migrantischen Mitglieder. Weiterführende Rechte wie z. B. Anhörungsrechte, Antragsrechte und höhere Budgets waren umstritten – aber die Gremien waren in der Bürgerschaft wie bei den Gemeinderatsmitgliedern akzeptiert. Diese demokratischen Innovationen in beiden Ländern wurden am Ende der 2010er teilweise zurückgenommen und die Migrationsräte als Kommissionen zum Teil der Lokalverwaltung untergeordnet. Im sächsischen Leipzig wurde dem Migrationsrat weitreichende Rechte übertragen – aber die Urwahl erst 2020 implementiert. Die vergleichenden Untersuchungen greifen den Konflikt um Anerkennung dieser Rechte in Gelsenkirchen, Leipzig und in der hessischen Kleinstadt Bebra auf. Der Beitrag beschreibt den divergierenden rechtlichen Rahmen, die politische Kultur, die historischen Auseinandersetzungen bei der Einführung der Migrationsräte, Konflikte bei der Ausweitung der Rechte und der Ressourcen wie auch die Probleme der Migrationsräte. Dabei spielen als Akteure externe Advokatoren, wie die Wohlfahrtsverbände, Kirchen, politische Parteien und die kommunalen Verwaltungen eine zentrale Rolle.
Genetic insights into an Apennine population of the Italian red deer
Authors: Giovannelli Francesca , Mori Emiliano , Zaccaroni Marco , Dessì-Fulgheri Francesco , Baratti Mariella 
Published: May 2022

AbstractThe red deer Cervus elephus has been a common species in Italy until the Middle Ages and the Renaissance, when its distribution range started to considerably decrease, due to gradual deforestation and hunting pressure. Afterwards, the red deer has been reintroduced to many regions of the world, including Italy. In the Italian Apennines, the Acquerino-Cantagallo Natural Reserve (ACQUERINO) hosts one of the largest peninsular red deer populations, originated from a series of successful reintroductions. In this study, we meant to detect the level of genetic variability of Acquerino-Cantagallo Natural Reserve deer population and to investigate the genetic relationships with the other Italian and European populations. We identified five mitochondrial DNA control region (D-loop) haplotypes, four falling in lineage A and one falling in lineage C, derived from at least two maternal lineages, confirming that ACQUERINO population should be the result of multiple reintroductions. Haplotype diversity (H = 0.50) and nucleotide (π = 0.004) diversity were low, but included into the deer range values. ACQUERINO population showed low levels of genetic diversity when compared to other European and Mediterranean populations, confirming that this expanding population may have been generated from a low number of founders.
Artemyrianosins A–J, cytotoxic germacrane-type sesquiterpene lactones from Artemisia myriantha
Authors: Zhang Xin , Ma Yun-Bao , He Xiao-Feng , Li Tian-Ze , Geng Chang-An , Su Li-Hua , Tang Shuang , Gao Zhen , Chen Ji-Jun 
Published: May 2022

AbstractTen new germacrane-type sesquiterpenoids, artemyrianosins A–J (1–10), were isolated from the aerial parts of Artemisia myriantha. Their structures were elucidated by spectral analyses including UV, IR, HRESIMS, 1D and 2D NMR, ECD and the absolute configurations of compounds 1 and 7–9 were characterized using X-ray crystallography. All isolates were tested their cytotoxicity against three human hepatoma cell lines (HepG2, Huh7, and SK-Hep-1), and compounds 1–3, 7, and 10 showed cytotoxicity with IC50 values ranging from 43.7 to 89.3 μM. Among them, the most active compound 3 exhibited activity against three human hepatoma cell lines with IC50 values of 43.7 μM (HepG2), 47.9 μM (Huh7), and 44.9 μM (SK-Hep-1).
Graphical Abstract
Hepatocyte Mitochondrial Dynamics and Bioenergetics in Obesity-Related Non-Alcoholic Fatty Liver Disease
Authors: Legaki Aigli-Ioanna , Moustakas Ioannis I. , Sikorska Michalina , Papadopoulos Grigorios , Velliou Rallia-Iliana , Chatzigeorgiou Antonios 
Published: May 2022

Abstract

Purpose of the Review

Mitochondrial dysfunction has long been proposed to play a crucial role in the pathogenesis of a considerable number of disorders, such as neurodegeneration, cancer, cardiovascular, and metabolic disorders, including obesity-related insulin resistance and non-alcoholic fatty liver disease (NAFLD). Mitochondria are highly dynamic organelles that undergo functional and structural adaptations to meet the metabolic requirements of the cell. Alterations in nutrient availability or cellular energy needs can modify their formation through biogenesis and the opposite processes of fission and fusion, the fragmentation, and connection of mitochondrial network areas respectively. Herein, we review and discuss the current literature on the significance of mitochondrial adaptations in obesity and metabolic dysregulation, emphasizing on the role of hepatocyte mitochondrial flexibility in obesity and NAFLD.

Recent Findings

Accumulating evidence suggests the involvement of mitochondrial morphology and bioenergetics dysregulations to the emergence of NAFLD and its progress to non-alcoholic steatohepatitis (NASH).

Summary

Most relevant data suggests that changes in liver mitochondrial dynamics and bioenergetics hold a key role in the pathogenesis of NAFLD. During obesity and NAFLD, oxidative stress occurs due to the excessive production of ROS, leading to mitochondrial dysfunction. As a result, mitochondria become incompetent and uncoupled from respiratory chain activities, further promoting hepatic fat accumulation, while leading to liver inflammation, insulin resistance, and disease’s deterioration. Elucidation of the mechanisms leading to dysfunctional mitochondrial activity of the hepatocytes during NAFLD is of predominant importance for the development of novel therapeutic approaches towards the treatment of this metabolic disorder.
Clinical Considerations of Ultra-processed Food Addiction Across Weight Classes: an Eating Disorder Treatment and Care Perspective
Authors: Wiss David 
Published: May 2022

AbstractPurpose of ReviewTo examine the prevalence rates of ultra-processed food addiction across different weight classes and offer guidelines for diagnosis and treatment. Clinicians are provided with practical considerations in the assessment of ultra-processed food addiction beyond the use of validated instruments.Recent FindingsThe weighted mean prevalence of ultra-processed food addiction is approximately 20% worldwide and varies widely based on the sample. At first glance, there appears a linear relationship between ultra-processed food addiction and BMI class. Further investigation indicates a J-shaped curve with heightened prevalence among the underweight. These findings highlight the need to assess for additional factors that may increase objective or subjective food addiction symptoms including eating disorders, dietary restraint, and other mental health diagnoses.SummaryWhile clinical considerations across different weight classes vary, overemphasis on weight status may detract from the clinical utility of the ultra-processed food addiction construct. Considering weight status in conjunction with other psychiatric symptoms helps to better understand the various biopsychosocial mechanisms that influence eating behavior and can inform individualized treatment strategies.