bluuebunny/crossref_metadata_2025_split huggingface dataset:
Phase I study of AIC100 in relapsed and/or refractory advanced thyroid cancer and anaplastic thyroid cancer.
Authors: Hsu Jing Mei , von Hofe Eric , Hsu Yen-Michael , Shieh Jae-Hung , Chaekal Ok-Kyong , Guarneri Danielle , Fahey Thomas J. , Ivanidze Jana , Puc Janusz , Du Karrie , You Ashlee , Scognamiglio Theresa , Vasovic Ljiljana , Cushing Melissa , Jin Moonsoo , Van Besien Koen 
Published: June 2022

6093 Background: ICAM-1 is a cell surface glycoprotein that is typically expressed on endothelial cells and immune cells and a ligand for LFA-1 integrin. It is also overexpressed in several malignancies, in particular anaplastic and advanced thyroid cancer. We designed an affinity tuned ICAM-1-directed CAR T cell (micromolar affinity) that preferentially binds overexpressed ICAM-1 on tumor cells and spares normal cells. The CAR T cells also express somatostatin receptor 2 (SSTR2), which allows tracking of CAR T cells in vivo via DOTATATE PET/CT scan. Murine studies showed excellent responses in ICAM-1 expressing thyroid cancer without significant toxicities. We are conducting a first-in-human phase 1 clinical trial to evaluate the feasibility, safety and preliminary efficacy of ICAM-1 in patients with relapsed/refractory thyroid cancer or anaplastic thyroid cancer who are BRAF wild-type, or BRAF mutated after failure of BRAF specific therapy (NCT04420754). Methods: This is a dose-escalation study with modified toxicity probability interval design and cohorts of 3 Patients. Patients receive a single dose of 1x 107 (Cohort 1), 1 x 108 (Cohort 2) or 5 x 108 (Cohort 3) ICAM-1 CAR T cells after FLU/CY lymphodepleting (LD) chemotherapy. Additional CAR T infusion is allowed if patients achieve partial response or stable disease. Whole-body Fluorodeoxyglucose (FDG) and DOTATATE PET/CT is used to stage tumor and track CAR T cells in vivo, respectively. Results: All ICAM-1 CAR T infusion products met target transduction efficiency. Two patients with progressive anaplastic thyroid cancer received ICAM-1 CAR T therapy at dose-level I. Evaluation of CAR T cellular kinetics demonstrated transient peripheral blood CAR T cell expansion. One patient developed grade 1 cytokine release syndrome (CRS) with fever. Several tumor lesions from this patient showed DOTATATE avidity, indicating CAR T homing to the tumor, concomitant with decrease in FDG avidity, suggesting biological activity at ̃2 weeks post CAR T infusion. DOTATATE avidity at 2 weeks post CAR T infusion also appeared to match that of CAR T abundance in the blood. Updated results on additional patients and cohorts will be presented. Conclusions: Adoptive cellular therapy with ICAM-1 directed CAR T is safe and feasible at dose level 1 in patients with anaplastic thyroid cancer. DOTATATE PET allows visualization of expansion and homing of SSTR2 expressing CAR T cells, while concomitant FDG PET permits correlation with biological activity. Clinical trial information: NCT04420754.
The Effects of Diabetes and Glycemic Control on Cancer Outcomes in Individuals With Metastatic Breast Cancer
Authors: Cheung Yee-Ming M , Hughes Melissa , Harrod Julia , Files Janet , Kirkner Greg , Buckley Lauren , Lin Nancy U , Tolaney Sara M , McDonnell Marie E , Min Le 
Published: June 2022

Abstract

Background
It is unclear whether diabetes and glycemic control affects the outcomes of breast cancer, especially among those with metastatic disease. This study aims to determine the impact of diabetes and hyperglycemia on cancer progression and mortality in individuals with metastatic breast cancer (MBC).

Methods
Patients with a diagnosis of MBC between 2010 and 2021 were identified using the MBC database at 2 academic institutions. We evaluated the effects of diabetes and glycemic control on overall survival (OS) and time to next treatment (TTNT).

Results
We compared 244 patients with diabetes (median age 57.6 years) to 244 patients without diabetes (matched for age, sex, ethnicity, and receptor subtype). OS at 5 years [diabetes: 54% (95% CI 47-62%) vs controls: 56% (95% CI 49-63%), P = 0.65] and TTNT at 1 year [diabetes: 43% (95% CI 36-50%) vs controls: 44% (95% CI 36-51%), P = 0.33] were similar between groups. A subgroup analysis comparing those with good glycemic control and those with poor glycemic control among patients with specific receptor subtype profiles showed no differences in OS at 5 years or TTNT at 1 year. In an 8-year landmark subgroup analysis, there was worse OS among individuals with diabetes compared to controls, and OS was found to be better among those with good glycemic control compared to those with poor control.

Conclusions
Diabetes was not associated with increased mortality in individuals with MBC at 5 years. However, diabetes and hyperglycemia were associated with worse OS among a cohort of longer-term survivors. These findings suggest that individualized diabetes and glycemic goals should be considered in patients with MBC.
Evaluation of the compatibility of C2, C3, and C4 fractal dimension values with hand-wrist and cervical vertebra maturation methods in determining skeletal maturation
Authors: Pamukcu Umut , Ispir Nebiha Gozde , Akay Gulsun , Karadag Atas Ozge , Gungor Kahraman , Toraman Meryem 
Published: June 2022

Objectives: To examine the correlation between the fractal dimension (FD) values of cervical vertebrae (C2, C3, and C4) and hand-wrist maturation (HWM) and cervical vertebra maturation (CVM) methods. In addition, the correlation between the pubertal growth spurt (PGS) and FD values was examined. Methods: The lateral cephalometric and hand-wrist radiographs of 120 subjects (61 females and 59 males) aged 8–18 years with a mean age of 13 years, were evaluated retrospectively. The CVM stages were determined in accordance with Hassel-Farman’s modification of Lamparski criteria. The HWM stages were determined in accordance with Björk and Grave-Brown criteria. Both HWM and CVM stages were divided into two according to PGS. Fractal analysis of cervical vertebrae was performed according to the White-Rudolph method. The relationships between HWM stages, CVM stages and other variables were evaluated by Spearman’s rank-order correlation coefficient. The relationships between FD values, chronological age, and divided stages were evaluated by the Pearson correlation coefficient. The Mann–Whitney U test was used to compare the FD values of two divided stages. Results: There were positive and statistically significant positive correlations between chronological age and both HWM and CVM stages. There was a positive and statistically significant correlation between CVM and HWM stages. In females and total, there were negative and statistically significant correlations between C4 FD values and divided HWM stages, and the differences between C4 FD values of divided HWM stages were also statistically significant. In total, there was a negative and statistically significant correlation between C4 FD values and divided CVM stages, and the difference between C4 FD values of divided CVM stages was also statistically significant. Conclusion: The negative correlations found between C4 FD values and divided HWM and CVM stages suggest the fractal analysis of cervical vertebrae, especially of C4, may be used as an objective tool for evaluating the PGS.
Effectiveness of a peanut ball device during labour on maternal and neonatal outcomes: protocol for a randomised controlled trial
Authors: Kamath Pratibha , Pai Muralidhar , Shenoy Revathi , Karkada Sushmitha , D’souza Sonia , Noronha Judith 
Published: June 2022

Frequent positional changes and movements during labour is one of the recommendations by the World Health Organization (WHO) to prevent prolonged labour, thereby avoiding cesarean sections. However, labour induction, continuous fetal monitoring in supine position and immobilising the women during labour are standard practices in most private hospitals. To combat these problems and to implement WHO recommendations, the peanut ball is an effective device through which frequent positional changes will be achieved without disrupting the labour procedures. The current study aims to evaluate the effectiveness of the peanut ball device during labour on maternal and neonatal outcomes and assess the stress response induced by labour in terms of maternal and neonatal cortisol in low-risk primigravid women. The study is a prospective, block randomised controlled trial with parallel arms. A total of 768 study participants will be randomised to the peanut-ball group (intervention) and standard care group (control). The intervention group will receive different peanut ball positions during labour at or after 4 cm of cervical dilatation. The primary outcomes of the study are maternal outcome that includes measurement of duration of the active and the second stage of labour, stress level as measured by serum cortisol level at 3–4 cm and at 10 cm of cervical dilatation, mode of delivery, perception of pain, behavioural response during the active stage of labour and neonatal outcomes, which includes the pattern of fetal heart rate, APGAR score, birth injuries, and umbilical serum and salivary cortisol level. The collected data will be compared between the intervention and control groups. Trial Registration: This research is registered under the CTRI (Clinical Trials Registry of India) (CTRI/2019/08/020802) (21/8/2019).
Tourette syndrome research highlights from 2021
Authors: Hartmann Andreas , Andrén Per , Atkinson-Clement Cyril , Czernecki Virginie , Delorme Cécile , Debes Nanette Marinette , Szejko Natalia , Ueda Keisuke , Black Kevin 
Published: June 2022

We summarize selected research reports from 2021 relevant to Tourette syndrome that the authors consider most important or interesting. The authors welcome article suggestions and thoughtful feedback from readers.
Project Management in the Field of Culture and Art
Authors: Sapelkina M. 
Published: June 2022

Project management practices in various spheres of human activity have received a considerable interest over the past few decades on the territory of the Russian Federation. In the modern world, considering an increase in the role of culture in socio-economic transformations, project management can be viewed as the most effective way to create the combination of traditional and innovative principles and the necessary measures to address various problems. However, little is known about the vital processes of project management in the arts sphere and the obstacles encountered in its implementation. The proposed study generalizes the experience of project application and seeks to define a methodology for strengthening cultural policy with the project-based approach.
The relevance of the findings for governmental and non-governmental employees and the potential implications for future research will be discussed.
Innovations in IPO Deal Structure: Do Up-C IPOs Harm Public Shareholders?
Authors: Billings Mary Brooke , Hsueh Kevin , Lewis-Western Melissa F. , Shobe Gladriel 
Published: June 2022

This paper examines an innovation in capital formation that has spurred contentious debate: the Umbrella Partnership Corporation (“Up-C”) IPO. Advisors and underwriters argue that the Up-C deal structure is a driver of post-IPO value and, thus, is a value-enhancing means of raising capital that may be one solution to concerns regarding the drop in the number of publicly traded companies. Consistent with these claims, recent research suggests that organizing soon-to-be public businesses as pass-through entities (as is the case for Up-Cs) leads to superior future performance. Yet, broadening the analysis to consider abnormal stock performance and post-IPO litigation of a larger and more recent sample of exclusively Up-C IPOs, we conclude just the opposite. While the Up-C deal structure increases IPO valuations and predicts positive post-IPO operating performance, the return performance of Up-C IPOs indicates that Up-C deals harm public shareholders. Further, despite their superior earnings performance, Up-C IPOs face a significantly higher rate of post-IPO litigation as compared with non-Up-C IPOs. Because IPO investors seemingly do not anticipate the myriad ways in which the Up-C deal structure might facilitate opportunism by pre-IPO owners, they frequently turn to litigation as an ex-post settling-up mechanism. Consequently, our paper offers the first empirical evidence of downsides associated with the Up-C deal structure for public shareholders and, in so doing, affords the rarity of having academic evidence lead (as opposed to respond to) a controversial debate. This paper was This paper was accepted by Victoria Ivashina, finance. Funding: The authors gratefully acknowledge the financial support of the NYU Stern School of Business, the J. Reuben Clark Law School, and the Marriott School of Business. Supplemental Material: Data are available at https://doi.org/10.1287/mnsc.2022.4454 .
Rosalina Santa Cruz: uma trajetória radical de lutas e resistência
Authors: De Melo Ana Inês Simões Cardoso , Cesar Monica De Jesus 
Published: June 2022

Entrevista com Rosalina de Santa Cruz Leite, conhecida no meio acadêmico-profissional como Rosalina Santa Cruz, é assistente social, doutora em Ciências Sociais, professora da Pontifica Universidade Católica de São Paulo (PUC/SP), com publicações nas áreas de gênero, direitos humanos e crianças e adolescentes. Rosalina Santa Cruz personifica memórias de lutas e resistências.
PENGARUH SIZE, NPL, EQUITY TO ASSET RATIO, LDR, GWM, LABOR PRODUCTIVITY DAN MARKET CONCENTRATION TERHADAP KINERJA BANK (Studi pada Bank Umum Konvensional yang Terdaftar di BEI Tahun 2014-2018)
Authors: Kristiawan Rochmad , Prasetiono Prasetiono 
Published: June 2022

The existence of different levels of bank’s performance in each Indonesian banks and the existence of banks with under level performance makes research on the factors that influence bank’s performance becomes more important to be examined. The aim of the research is to analyze the effect of size, size, Non-performing Loan (NPL), Equity to Asset Ratio (EAR), Loan to Deposit Ratio (LDR), reserve requirement (GWM), labor productivity and market concentration (which is proxied by market share of each bank) on the performance of listed conventional banks in Indonesia. The bank’s performance in this research is measured by Return on Asset (ROA).The research sample used are 25 listed conventional banks in Indonesia for the 2014-2018 period. The data selection method used in this research is purposive sampling method. The hypothesis testing of this study using multiple linear regression analysis with SPSS 26 program.The study found that size, Equity to Asset Ratio (EAR), labor productivity and market share have a significant positive effect on bank’s performance. Non-performing Loan (NPL) have a significant negative effect on bank’s performance. Loan to Deposit Ratio (LDR) and Reserve requirement (GWM) have a positive but not significant effect on bank’s performance
The shape of a word: single word characteristics’ effect on novice L2 listening comprehension
Authors: Patterson Allie 
Published: June 2022

Abstract
The purpose of this study was to expand upon available research which quantifies the relationship between single word characteristics and L2 listening comprehension. The effect of single word characteristics on L2 listening have been mostly studied in isolation in past research. Furthermore, little research exists on listening comprehension during the first years of L2 acquisition. To begin filling this gap, 172 English L2 novice participants were administered an isolated phrase transcription test in which participants must quickly attempt to transcribe phrases of four to five words they hear only one time. The independent variable word characteristics in this study were part of speech, phrasal position, word length, frequency, and Minkowski3 sensorimotor norms, an embodiment semantic variable. Word transcription probability (i.e., whether a word was transcribed or not) was analyzed using Rasch analysis and hierarchical linear mixed effects regression. Part of speech and phrasal position did not significantly predict word transcription probability. Word length, frequency, and Minkowski3 sensorimotor norms significantly predicted transcription probability. The findings of this study have implications for the creation of listening texts and theoretical models of L2 listening comprehension.
Making sense of trans-translating in blogger subtitling: a netnographic approach to translanguaging on a Chinese microblogging site
Authors: Mao Yifei , Lin Zhong , Wang Feng 
Published: June 2022

Abstract
The online digital sphere has recently witnessed a rapid growing of amateur audiovisual translation, which not only reinvigorates the current body of translation scholarship but also calls for a paradigm shift from the entrenched monolingualism. Though a plethora of studies have been conducted on fansubbing, little is known about blogger subtitling. Drawing on the netnographic data from a subtitling video blogger, @暴躁鸭仔 (baozao yazai, Grumpy Duckling for English) on a microblogging site (Weibo) in the mainland of China, we explored trans-translating by examining the translanguaging involved in the blogger’s subtitling translation. It is revealed that the blogger makes a hybrid, integrated use of multiple semiotic, orthographic, discursive and modal resources, without being confined by the boundaries amongst nameable languages, or linguistic/non-linguistic codes. The orchestration of the unified heterolingual repertoire builds up a social-media translanguaging space, wherein the tensions between translation and translanguaging due to distinct conceptual schemas are manipulated to yield synergy insofar as they dovetail into ingenious language making. We concluded that such creative translation can be retheorized as a process of trans-translating to encapsulate the subtitling experience in light of its dynamic and fluid nature, and transformative power of translanguaging. The results of this research might add to the picture of amateur subtitling and translation and that of translanguaging as well as their relation to one another.
Data mining and mathematical models in cancer prognosis and prediction
Authors: Yu Chong , Wang Jin 
Published: June 2022

Abstract
Cancer is a fetal and complex disease. Individual differences of the same cancer type or the same patient at different stages of cancer development may require distinct treatments. Pathological differences are reflected in tissues, cells and gene levels etc. The interactions between the cancer cells and nearby microenvironments can also influence the cancer progression and metastasis. It is a huge challenge to understand all of these mechanistically and quantitatively. Researchers applied pattern recognition algorithms such as machine learning or data mining to predict cancer types or classifications. With the rapidly growing and available computing powers, researchers begin to integrate huge data sets, multi-dimensional data types and information. The cells are controlled by the gene expressions determined by the promoter sequences and transcription regulators. For example, the changes in the gene expression through these underlying mechanisms can modify cell progressing in the cell-cycle. Such molecular activities can be governed by the gene regulations through the underlying gene regulatory networks, which are essential for cancer study when the information and gene regulations are clear and available. In this review, we briefly introduce several machine learning methods of cancer prediction and classification which include Artificial Neural Networks (ANNs), Decision Trees (DTs), Support Vector Machine (SVM) and naive Bayes. Then we describe a few typical models for building up gene regulatory networks such as Correlation, Regression and Bayes methods based on available data. These methods can help on cancer diagnosis such as susceptibility, recurrence, survival etc. At last, we summarize and compare the modeling methods to analyze the development and progression of cancer through gene regulatory networks. These models can provide possible physical strategies to analyze cancer progression in a systematic and quantitative way.
Exploring phytochemical constituents ofAchillea arabicaKotschy. ethanolic flower extract by LC-MS/MS and its possible antioxidant and antidiabetic effects in diabetic rats
Authors: Hanalp Hanife Ceren , Dogan Abdulahad , Saygi Tuba Kusman , Donmez Fatih , Battal Abdulhamit 
Published: June 2022

AbstractThe aim of this study was to reveal the antidiabetic and antioxidant effects of ethanolic lyophilized extract ofAchillea arabicaflower extract against streptozotosine (STZ)-induced in diabetic rats and to determine its phytochemical content by liquid chromatography with tandem mass spectrometry (LC-MS/MS). After toxicity test, 35 female rats were divided into five groups. Control, diabetes mellitus (DM),A.arabica(400 mg/kg) extract, DM + A. arabica(400 mg/kg) extract and DM + Glibenclamide (2 mg/kg). It was determined that while diabetic rats treatedA.arabicaplant extract significantly decreased blood glucose level, serum glucose, HbA1c, liver and kidney damage biomarker levels, and malondialdehyde (MDA) content compared to the DM group, it caused fluctuations in antioxidant enzyme levels. According to LC-MS/MS results ofA. arabicaflower extract, quinic acid (2439.9 μg/g), cyranoside (858.4 μg/g), chlorogenic acid (698.7 μg/g), and cosmosiin (347.8 μg/g) were determined as major compounds, respectively. In addition, two new compounds were determined in this extract according to nuclear magnetic resonance (NMR) and Mass analyses and these compounds were named edremitine and achillosine, respectively. Thus,A.arabicaflower extract has possible therapeutic effects to prevent high blood glucose level and oxidative stress caused by DM in liver and kidney via its high phenolic content.
Gastric stem cells promote inflammation and gland remodeling in response to Helicobacter pylori via Rspo3‐Lgr4 axis
Authors: Wizenty Jonas , Müllerke Stefanie , Kolesnichenko Marina , Heuberger Julian , Lin Manqiang , Fischer Anne‐Sophie , Mollenkopf Hans‐Joachim , Berger Hilmar , Tacke Frank , Sigal Michael 
Published: June 2022

AbstractHelicobacter pylori is a pathogen that colonizes the stomach and causes chronic gastritis. Helicobacter pylori can colonize deep inside gastric glands, triggering increased R‐spondin 3 (Rspo3) signaling. This causes an expansion of the “gland base module,” which consists of self‐renewing stem cells and antimicrobial secretory cells and results in gland hyperplasia. The contribution of Rspo3 receptors Lgr4 and Lgr5 is not well explored. Here, we identified that Lgr4 regulates Lgr5 expression and is required for H. pylori‐induced hyperplasia and inflammation, while Lgr5 alone is not. Using conditional knockout mice, we reveal that R‐spondin signaling via Lgr4 drives proliferation of stem cells and also induces NF‐κB activity in the proliferative stem cells. Upon exposure to H. pylori, the Lgr4‐driven NF‐κB activation is responsible for the expansion of the gland base module and simultaneously enables chemokine expression in stem cells, resulting in gland hyperplasia and neutrophil recruitment. This demonstrates a connection between R‐spondin‐Lgr and NF‐κB signaling that links epithelial stem cell behavior and inflammatory responses to gland‐invading H. pylori.