bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dopant‐Induced Giant Photoluminescence of Monolayer MoS2 by Chemical Vapor Transport
Authors: Ma Zhao , Ren Caixia , Wu Yu , Qiu Hailong , Liu Hongjun , Hu Zhanggui , Wu Yicheng 
Published: August 2022

AbstractSubstitutional doping of 2D transition metal dichalcogenides (TMDCs) has been recognized as a promising strategy to tune their optoelectronic properties for a wide array of applications. However, controllable doping of TMDCs remains a challenging issue due to the natural doping of these materials. Here, the controllable growth of Ti‐doped MoS2 monolayers is demonstrated via the chemical vapor transport method, and the atomic embedded structure is confirmed by scanning transmission electron microscope with a probe corrector measurements. Furthermore, the grown Ti‐doped MoS2 monolayer exhibits giant photoluminescence (PL), 85‐fold stronger than a pristine MoS2 monolayer prepared by the same method. The giant PL enhancement is attributed to dopant‐induced O‐Ti‐S units and improved interaction between the monolayer and the mica substrate, increasing the photoluminescence quantum yield and facilitating radiation recombination. The successful growth of Ti‐doped MoS2 monolayer and the improvement of its optical and electrical properties by Ti doping may provide a promising method to engineer the optoelectronic properties of 2D TMDCs materials.
Additively Manufactured Polarization Insensitive Broadband Transmissive Metasurfaces for Arbitrary Polarization Conversion and Wavefront Shaping
Authors: Zhu Jianfeng , Yang Yang , Lai Jiexin , Nulman Jaim 
Published: August 2022

AbstractArbitrarily manipulating the polarization and wavefront of electromagnetic waves using ultrathin and highly efficient devices is desirable for many systems. Ultrathin broadband polarization‐insensitive transmissive metasurfaces, which can achieve the same polarization conversion and wavefront shaping for arbitrary linearly polarized incident waves, are proposed. The meta‐atom is composed of a transmitting antenna and a receiving antenna with a group of phase delay lines connecting them. The rotation of the transmitting antenna introduces the polarization conversion, and the different lengths of the transmission lines provide [−π, π] phase shift for wavefront shaping. Both the polarization conversion and wavefront shaping functions are polarization insensitive. Differential feeding is applied to both the transmitting and the receiving patch antennas to improve the transmission efficiency. The prototypes are conveniently printed by using the additive manufacturing technique. Two polarization‐insensitive metasurfaces are designed and measured to demonstrate. One of them produces vortex beams with 90° polarization conversion, and the other achieves anomalous refraction with 45° polarization conversion.
Coupling Intracompound Charge Transfer and Cluster‐Centered Excited States in Cu(I) Halide Hybrids for Efficient White Light Emission
Authors: Liu Xing , Li Yue , Zhou Lei , Li Ming , Zhou Yuanyuan , He Rongxing 
Published: August 2022

Abstract0D hybrid organic–inorganic metal halides have attracted significant interest due to their unique optoelectronic properties, but attainment of efficient and stable white light emission (WLE) in such compounds remains a challenge. Here, efficient WLE via a molecular design that couples intracompound charge transfer and cluster‐centered excited states in 0D halide hybrids is demonstrated. Two Cu(I) halide hybrids, K(18‐crown‐6)Cu2Br3 and Na4(18‐crown‐6)5In2Cu4Br14·8H2O, are synthesized wherein luminescent [Cu4Br6]2− clusters are isolated from each other and surrounded by 18‐crown‐6 coordinated alkali metal cations. In the case of K(18‐crown‐6)Cu2Br3, [Cu4Br6]2− clusters are only partially isolated, leading to strong orange emission with a photoluminescence quantum yield (PLQY) of 53% under UV excitation. Strikingly, to a larger extent of isolation as that, in Na4(18‐crown‐6)5In2Cu4Br14·8H2O as a result of the incorporation of nonemissive [InBr4]− clusters, intense white light emission with a PLQY of 97% is achieved. The dual cluster‐centered states, coupled with a mixed metal‐to‐ligand and halide‐to‐ligand charge transfer state, are responsible for this bright white luminescence. This work provides new design principles for expanding the materials library for single‐component, solid‐state WLE.
Development of Multifunctional Materials Based on Heavy Concentration Er3+‐Activated Lead‐free Double Perovskite Cs2NaBiCl6
Authors: Zhu Keming , Wang Zhiying , Xu Hanyu , Fu Zuoling 
Published: August 2022

AbstractLead halide perovskites have been very promising for versatile optoelectronic applications, whereas the inherent toxicity and instability of lead halide restrict its wide application. Herein, a kind of high‐performance multifunctional phosphor is designed based on heavy concentration Er3+‐activated lead‐free double perovskite Cs2NaBiCl6 (CNBC), which realizes the self‐sensitization of Er3+ ions and emits high‐brightness pure green emission upon dual near‐infrared (dual‐NIR) excitation. The luminescence properties can be further optimized by adding sensitizers (Yb3+/Nd3+). Interestingly, the emission intensity of the green region is heightened by 212‐fold after Yb3+ ions doping, which is 40 times higher than that of the current popular phosphors (α‐NaYF4:2%Er3+,18%Yb3+). Meanwhile, the temperature sensing properties of the thermally coupled levels (Er3+:2H11/2,4S3/2) in Cs2NaBiCl6:40%Er3+ are also investigated systematically based on the luminescence intensity ratio principle, and the maximum relative sensitivity is calculated to be as high as 1.27% K‐1 (980 nm) and 1.57% K‐1 (808 nm). Fortunately, the thermal stability and the performance for temperature readout of the studied phosphors are still maintaining a high level after doping sensitizers. The insights provided by this work will broaden the scope of lead‐free halide double perovskites in the fields of luminescence and thermometry.
Light Emitting Si‐Based Mie Resonators: Toward a Huygens Source of Quantum Emitters
Authors: Khoury Mario , Quard Hugo , Herzig Tobias , Meijer Jan , Pezzagna Sébastien , Cueff Sébastien , Abbarchi Marco , Nguyen Hai Son , Chauvin Nicolas , Wood Thomas 
Published: August 2022

AbstractSilicon‐based micro‐ and nano‐structures for light management at near‐infrared and visible frequencies have been widely exploited for guided optics and metasurfaces. However, light emission with this material has been hampered by the indirect character of its bandgap. Here it is shown that, via ion beam implantation, light emitting G‐centers can be directly embedded within Si‐based Mie resonators previously obtained by solid state dewetting. Size‐ and position‐dependent, directional light emission at 120 K is demonstrated experimentally and confirmed by finite difference time domain simulations. It is estimated that, with an optimal coupling of the G‐centers emission with the resonant antennas, a collection efficiency of about 90% can be reached using a conventional objective lens. The integration of these telecom‐frequency emitters in resonant antennas is relevant for their efficient exploitation in quantum optics applications and more generally to Si‐based photonic metasurfaces.
Cryotronic Low‐Powered Strained Polymorphic Photodetector Functionalized by Palladium Incorporated Tin Diselenide
Authors: Gupta Shubham Umeshkumar , Dalvaniya Ankit G. , Chauhan Payal , Patel Keeritkumar D. , Solanki Gunvant K. , Pathak Vivek M. , Jha Prafulla K. 
Published: August 2022

AbstractResearchers’ challenging task is to develop a material that can bear extreme environmental conditions. In this context, ‘metal dichalcogenide’ based solid‐state devices are highly beneficial for cryogenic optoelectronic applications but rarely reported. Herein, novel meta‐materials PdxSn1−xSe2 (x = 0.0, 0.2, 0.4) and their photodetector application are introduced. These ternary crystals are grown by direct vapour transport (DVT) technique in which palladium incorporated SnSe2 crystals exhibit polymorphism of hexagonal‐orthorhombic multiphase. PdxSn1−xSe2 (x = 0.0, 0.2, 0.4) single crystal photodetectors (SCPDs) demonstrate excellent photodetection in which SCPD functionalized by Pd0.4Sn0.6Se2 displays superior photoresponse. Cryogenic temperature directed blue‐shifting and sharpening of Raman peak displays noteworthy thermal‐sensing ability. Captivatingly, 10 µV low‐powered Pd0.4Sn0.6Se2 SCPD demonstrates substantial photodetection with 2.41 × 108 Jones detectivity at the cryogenic temperature of 10 K. To the best of the authors’ knowledge, a photosensor that displays excellent photodetection at a very low bias of 10 µV applied to the detector at the cryogenic temperature of 10 K is reported for the first time by them in present investigation. Higher stability, reproductiveness, and a low‐powered operating ability at a cryogenic temperature of 10 K declares Pd0.4Sn0.6Se2 as a potential candidate to design next‐generation low‐powered optoelectronic applications in cryotronics.
Reevaluation of regional lymph nodes in patients with pancreatic ductal adenocarcinoma in the pancreatic body and tail
Authors: Matsui Yuki , Hashimoto Daisuke , Satoi Sohei , Yamamoto Tomohisa , Yamaki So , Ishida Mitsuaki , Hirooka Satoshi , Ikeura Tsukasa , Sekimoto Mitsugu 
Published: August 2022

AbstractIntroductionIn patients with pancreatic ductal adenocarcinoma (PDAC) in the pancreatic body (Pb) and tail (Pt), the appropriate area for lymphadenectomy is controversial. This study aimed to reevaluate the extent of lymph node (LN) metastasis in Pb‐ and Pt‐PDAC, and to define the optimal area of LN dissection.Patients and methodsThis single‐center retrospective study evaluated patients with Pb‐ and Pt‐PDAC who underwent distal pancreatectomy with extended lymphadenectomy between 2006 and 2020. LN metastasis in >3.0% of patients were defined as new regional LN.ResultsThe study cohort included 135 patients with Pb‐PDAC and 42 patients with Pt‐PDAC. In patients with Pb‐PDAC, LNs around the splenic artery (SPA) had the highest metastasis‐positive rate (54.1%). LNs along the left gastric artery, common hepatic artery, celiac axis (CA), superior mesenteric artery (SMA), and splenic hilus were defined as new regional LNs. In patients with Pt‐PDAC, LNs at the splenic hilum had the highest metastasis‐positive rate (38.1%). The station and LN around the SPA were defined as new regional LNs in those with Pt‐PDAC. Metastasis beyond the newly defined regional LNs was not associated with survival. The incidence of LN metastasis was lower in patients who received preoperative chemotherapy than in those who underwent upfront surgery in both Pb‐ and Pt‐PDAC.ConclusionAlthough it needs to be verified in future multicenter studies, LN of both the CA and SMA systems should be dissected in patients with Pb‐PDAC. However, only those around the SPA and splenic hilus should be dissected routinely in those with Pt‐PDAC.
Wide range of phenotypic severity in individuals with late truncations unique to the predominant CDKL5 transcript in the brain
Authors: Keehan Laura , Haviland Isabel , Gofin Yoel , Swanson Lindsay C. , El Achkar Christelle Moufawad , Schreiber John , VanNoy Grace E. , O'Heir Emily , O'Donnell‐Luria Anne , Lewis Richard Alan , Magoulas Pilar , Tran Alyssa , Azamian Mahshid S. , Chao Hsiao‐Tuan , Pham Lisa , Samaco Rodney C. , Elsea Sarah , Thorpe Erin , Kesari Akanchha , Perry Denise , Lee Brendan , Lalani Seema R. , Rosenfeld Jill A. , Olson Heather E. , Burrage Lindsay C. ,   Undiagnosed Diseases Network
Published: August 2022

AbstractCyclin‐dependent kinase‐like 5 (CDKL5) deficiency disorder (CDD) is caused by heterozygous or hemizygous variants in CDKL5 and is characterized by refractory epilepsy, cognitive and motor impairments, and cerebral visual impairment. CDKL5 has multiple transcripts, of which the longest transcripts, NM_003159 and NM_001037343, have been used historically in clinical laboratory testing. However, the transcript NM_001323289 is the most highly expressed in brain and contains 170 nucleotides at the 3′ end of its last exon that are noncoding in other transcripts. Two truncating variants in this region have been reported in association with a CDD phenotype. To clarify the significance and range of phenotypes associated with late truncating variants in this region of the predominant transcript in the brain, we report detailed information on two individuals, updated clinical information on a third individual, and a summary of published and unpublished individuals reported in ClinVar. The two new individuals (one male and one female) each had a relatively mild clinical presentation including periods of pharmaco‐responsive epilepsy, independent walking and limited purposeful communication skills. A previously reported male continued to have a severe phenotype. Overall, variants in this region demonstrate a range of clinical severity consistent with reports in CDD but with the potential for milder presentation.
Salivary CGRP and Erenumab Treatment Response: Towards Precision Medicine in Migraine
Authors: Alpuente Alicia , Gallardo Victor J , Asskour Laila , Caronna Edoardo , Torres‐Ferrus Marta , Pozo‐Rosich Patricia 
Published: August 2022

ObjectiveWe aimed (1) to analyze salivary calcitonin gene‐related peptide (CGRP) levels in patients with migraine, (2) to predict erenumab response from baseline CGRP levels, and (3) to evaluate CGRP change post‐treatment.MethodsThis is a prospective observational study that measured salivary CGRP levels in healthy controls (HCs), patients with episodic migraine (EM) and patients with chronic migraine (CM). Participants collected saliva samples at baseline and, the patients who were candidates to receive erenumab, also collected saliva after 3 doses of treatment. We quantified CGRP‐like immunoreactivity (CGRP‐LI) by enzyme‐linked immunosorbent assay (ELISA) and we performed an analysis at baseline and post‐treatment through generalized linear mixed models.ResultsAt baseline, a higher headache frequency was associated with higher CGRP levels, those being even higher in the presence of depressive symptoms. A cutoff point (mean, 95% confidence interval [CI]) of 103.93 (95% CI = 103.35–104.51) pg/ml was estimated to differentiate migraine from controls with an area under the receiver operating characteristic (ROC) curve (AUC, 95% CI) of 0.801 (95% CI = 0.798–0.804). We also found that higher pretreatment salivary CGRP levels were statistically significantly associated to a higher probability of having 50% or greater reduction in headache frequency in patients with EM, but not in patients with CM. After 12 weeks of treatment with erenumab, salivary CGRP levels from patients within all spectrum of migraine frequency converged to similar CGRP values. In contrast, in patients with concomitant depressive symptoms, this convergence did not happen.InterpretationPatients with migraine not only have higher CGRP levels compared with HCs, but also the presence of depressive symptoms seems to increase salivary CGRP levels and we have evidence, for the first time, that baseline salivary CGRP concentration is associated with treatment response to erenumab. ANN NEUROL 2022;92:846–859
Successive Redox‐Reaction‐Triggered Interface Radical Polymerization for Growing Hydrogel Coatings on Diverse Substrates
Authors: Zhang Yunlei , Xu Rongnian , Zhao Weiyi , Zhao Xiaoduo , Zhang Liqiang , Wang Rui , Ma Zhengfeng , Sheng Wenbo , Yu Bo , Ma Shuanhong , Zhou Feng 
Published: August 2022

AbstractGrowing lubricating hydrogel coatings in controllable manners on diverse material surfaces demonstrates promising applications. Here, a surface modification method is reported for in situ growing hydrogel coatings onto surfaces of diverse substrates in the absence of UV assistance. It is performed by decorating substrates with a universal mussel‐inspired synthetic adhesive with catechol groups. Upon being immersed in reaction solution, these groups can assist substrate bonding and in situ capture and reduce Fe3+ into Fe2+ for decomposing S2O82− into SO4−⋅ catalytically at the interface to initiate interface polymerization of monomers. As a result, hydrogel coatings with controllable thickness could be grown on surfaces of arbitrary substrates to change their surface characteristics regardless of materials size, category, geometry and transparency, implying considerable potential in surface engineering.
A Carbon‐Carbon Bond Cleavage‐Based Prodrug Activation Strategy Applied to β‐Lapachone for Cancer‐Specific Targeting
Authors: Gong Qijie , Li Xiang , Li Tian , Wu Xingsen , Hu Jiabao , Yang Fulai , Zhang Xiaojin 
Published: August 2022

AbstractProdrugs are one of the most common strategies for the design of targeted anticancer agents. However, their application is often hampered by the modifiable groups available on parent drugs. Herein, a carbon‐carbon (C−C) bond cleavage‐based prodrug activation strategy is reported, which was successfully used to design prodrugs of β‐lapachone (β‐lap), anortho‐quinone natural product without traditional modifiable groups for the construction of C−N/C−O bond cleavage‐based prodrugs. The designed β‐lap prodrug with a reactive oxygen species‐specific trigger was quickly activated, releasing β‐lap. It exerted anticancer efficacy via NAD(P)H:quinone oxidoreductase 1 (NQO1)‐mediated futile redox cycling, resulting in potent cytotoxicity that was highly selective for NQO1‐rich cancer cells over normal cells both in vitro and in vivo. This significantly amplified the therapeutic window of β‐lap. This study provides a practical strategy for the design of prodrugs for parent drugs that do not contain traditional modifiable groups.
Autonomous Chiral Microswimmers with Self‐mixing Capabilities for Highly Efficient Enantioselective Synthesis
Authors: Arnaboldi Serena , Salinas Gerardo , Bonetti Giorgia , Garrigue Patrick , Cirilli Roberto , Benincori Tiziana , Kuhn Alexander 
Published: August 2022

AbstractThe development of chiral catalysts plays a very important role in various areas of chemical science. Heterogeneous catalysts have the general advantage of allowing a more straightforward separation from the products. One specific case of heterogeneous catalysis is electrocatalysis, being potentially a green chemistry approach. However, a typical drawback is that the redox conversion of molecules occurs only at the electrode/electrolyte interface, and not in the bulk of the electrolyte. The second limitation is that the electrodes have to be physically connected to a power supply to induce the desired reactions. To circumvent these problems, we propose here a complementary approach by replacing macroscopic electrodes with an ensemble of self‐propelled redox active microswimmers. They move autonomously in solution while transforming simultaneously a prochiral starting compound into a specific enantiomer with a very high enantiomeric excess, accompanied by a significantly increased production rate of the favorite enantiomer.
Cocoa butter equivalent from Kpangnan butter and Pequi oil
Authors: Ghazani Saeed M. , Guedes Andréa Madalena Maciel , Antoniassi Rosemar , Chiu Ming Chih , Marangoni Alejandro G. 
Published: August 2022

AbstractNovel cocoa butter equivalents were designed using dry fractionated Pequi oil and solvent fractionated Kpangnan butter. Static crystallization of binary mixtures into the triclinic form (β2) was achieved after 12 days of static crystallization at room temperature for all mixtures and after 4 days only for the 80:20 w/w and 90:10 w/w fractionated Kpangnan: Pequi oil mixtures. However, after 60 days of storage at 22°C, all binary blends (except 100% fractionated pequi oil and 100% fractionated Kpangnan butter) were crystallized in the most stable triclinic crystal form (β1). Here we also reported a higher melting behavior for the fractionated Pequi oil: fractionated Kpangnan (80:20 w/w and 90:10 w/w), after 4 days of static crystallization at room 22°C, which, based on the x‐ray results, could be addressed to completion of crystal polymorphic transition to the triclinic β2 form during 4 days of storage. Our results suggest that the 70:30 w/w fractionated Pequi oil: Kpangnan mixture after 60 days of storage at 22°C showed a melting point of 34°C, a stable triclinic β2 form, and a triglyceride composition of 28% POP, 4.6% POS, and 33% SOS displayed solid‐state characteristics, melting point, and crystal structure, of a novel cocoa butter equivalent.
Development of nanostructured green divalent manganese‐coordinated polyurea
Authors: Laxmi  , Shahzaib Adnan , Alam Manawwer , Ghosal Anujit , Zafar Fahmina , Nishat Nahid 
Published: August 2022

AbstractThe work presented here reports the greener synthesis of polyurea (GPUa) via in‐situ solvent‐free precipitation polymerization of toluene diisocyanate (TDI) (used as monomer) and water. The divalent manganese [Mn(II)] ions were incorporated into GPUa to form Mn(II)‐GPUa to enhance its applicability. The structure of GPUa and Mn(II)‐GPUa was validated by Fourier‐transform infrared and proton nuclear magnetic resonance spectral techniques. The morphology along with the elemental analysis of GPUa and Mn(II)‐GPUa was assessed by X‐ray diffraction analysis and field emission scanning electron microscopy along with energy‐dispersive X‐ray spectroscopy. Thermal degradation behavior and stability of GPUa and Mn(II)‐GPUa were investigated by thermo‐gravimetric, differential thermal, differential scanning calorimetry, and integral procedure decomposition temperature analysis. Furthermore, the batch adsorption method was used to examine the adsorption behavior of Mn(II)‐GPUa. The study's results indicated that Mn(II)‐GPUa might be used as an eco‐friendly, thermally stable material and adsorbent, making it suitable as an effective dye adsorbent for wastewater treatment. The current work is aligned with Green chemistry principles (Principles 1, 2, 3, 4, 5, 6, 8, and 12).
Dual Photoredox Cobalt Catalyzed [4+1] Annulation and C−H Alkoxylation
Authors: Kumar Shreemoyee , Nair Akshay M. , Volla Chandra M. R. 
Published: August 2022

AbstractHerein, we developed two distinct pyridineN‐oxide directed C−H activation protocols to achieve [4+1] annulation and alkoxylation of benzamide derivatives by merging Co‐catalysis with visible‐light photoredox catalysis. The protocols deliver the respective products in good yields under facile conditions at room temperature. The use of an inexpensive photocatalyst coupled with molecular oxygen bypassing the need of stoichiometric oxidants forms the chief highlight of the work. The protocols are scalable and the products could be further modified. Additionally, preliminary studies were carried out to probe the reaction mechanism.