bluuebunny/crossref_metadata_2025_split huggingface dataset:
Simulation‐based team‐training in acute stroke: Is it safe to speed up?
Authors: Høllesli Liv Jorunn , Ajmi Soffien Chadli , Kurz Martin W. , Tysland Thomas Bailey , Hagir Morten , Dalen Ingvild , Qvindesland Sigrun Anna , Ersdal Hege , Kurz Kathinka D. 
Published: November 2022

AbstractBackgroundIn acute ischemic stroke (AIS), rapid treatment with intravenous thrombolysis (IVT) is crucial for good clinical outcome. Weekly simulation‐based team‐training of the stroke treatment team was implemented, resulting in faster treatment times. The aim of this study was to assess whether this time reduction led to a higher proportion of stroke mimics (SMs) among patients who received IVT for presumed AIS, and whether these SM patients were harmed by intracranial hemorrhage (ICH).MethodsAll suspected AIS patients treated with IVT between January 1, 2015 and December 31, 2020 were prospectively registered. In 2017, weekly in situ simulation‐based team‐training involving the whole stroke treatment team was introduced. To analyze possible unintended effects of simulation training, the proportion of SMs among patients who received IVT for presumed AIS were identified by clinical and radiological evaluation. Additionally, we identified the extent of symptomatic ICH (sICH) in IVT‐treated SM patients.ResultsFrom 2015 to 2020, 959 patients were treated with IVT for symptoms of AIS. After introduction of simulation training, the proportion of patients treated with IVT who were later diagnosed as SMs increased significantly (15.9% vs. 24.4%, p = .003). There were no ICH complications in the SM patients treated before, whereas two SM patients suffered from asymptomatic ICH after introduction of simulation training (p = 1.0). When subgrouping SMs into prespecified categories, only the group diagnosed with peripheral vertigo increased significantly (2.5% vs. 8.6%, p < .001).ConclusionsSimulation training of the acute stroke treatment team was associated with an increase in the proportion of patients treated with IVT for a suspected AIS who were later diagnosed with peripheral vertigo. The proportion of other SM groups among IVT‐treated patients did not change significantly. No sICH was detected in IVT‐treated SM patients.
Patients with stage IA ovarian clear cell carcinoma do not require chemotherapy following surgery
Authors: Shuqing Li , Zhiling Zhu 
Published: November 2022

AbstractBackgroundOvarian clear cell carcinoma (OCCC) is an infrequent histological subtype of epithelial ovarian cancer (EOC). The present study aimed to investigate whether chemotherapy is indispensable for patients with stage IA OCCC.MethodsData were collected from the Surveillance, Epidemiology and End Results database between 2004 and 2015. All subjects were diagnosed with stage IA OCCC, according to their postoperative pathological reports. In the present study, 1038 patients were retrospectively investigated, among whom 692 patients received chemotherapy. Propensity score matching (PSM) was performed to prevent selection bias. The multivariate Cox proportional hazards model was used to analyze the correlation between variables and 5‐year overall survival.ResultsAn equal number of patients (n = 346) who did or did not undergo chemotherapy after PSM were further enrolled in the study. The results showed that the mortality of OCCC increased for the patients aged ≥50 years. In addition, older age was associated with lower 5‐year overall survival (p < 0.05). However, chemotherapy did not extend the 5‐year overall survival (p = 0.524) of patients with stage IA OCCC, according to the multivariate Cox regression analysis.ConclusionsChemotherapy did not affect the overall survival of patients with stage IA OCCC following surgery.
ABOblood groups and expression of blood group antigens of epithelial ovarian cancer in Chinese women
Authors: Wang Chao , Zhou Jingjing , Wang Lili , Xing Tongyu , Dai Hongji , Zhou Yao , Qi Lisha , Zhao Yanrui , Huang Caiyun , Li Ding , Li Haixin , Li Mulin Jun , Liu Ben , Zheng Hong , Chen Kexin , Li Lian 
Published: November 2022

AbstractBackgroundABO blood groups has been associated with risk of several cancers; however, the results for an association with ovarian cancer are inconsistent and little is known about the expression of histo‐blood group (ABH) antigens andABOgene in ovarian tumor tissues.MethodsTo assess the impact of genotype‐derived ABO blood types on the risk of EOC, we conducted a case–control study in 1,870 EOC and 4,829 controls. Expression of A and B antigen in 70 pairs of ovarian tumor tissues and adjacent normal tissues were detected by immunohistochemistry. Gene expression and DNA methylation profiling was conducted in ovarian tumor tissues.ResultsWe identified that blood group A was associated with increased risk for EOC compared to blood group O (OR = 1.18, 95% CI = 1.03–1.36,p = 0.019). Increased frequency of aberrant expression of histo‐blood group antigens was observed in patients with blood group A (76.5%) compared to patients with blood group O (21.1%) and B (5.0%) by immunohistochemistry (p < 0.001).ABOgene expression was down‐regulated in ovarian tumor tissues compared with paired adjacent normal tissues (p = 0.027). In addition,ABOgene expression was positively correlated withNFYB(r = 0.38,p < 0.001) and inversely correlated with DNA methylation level of four CpG sites on ABO gene (cg11879188,r = − 0.3,p = 0.002; cg22535403,r = − 0.30,p = 0.002; cg13506600,r = − 0.22,p = 0.025; cg07241568,r = − 0.21,p = 0.049) in ovarian tumor tissues.ConclusionWe identified blood group A was associated with increased EOC risk in Chinese women and provided the clues of the possible molecular mechanisms of blood group A related to ovarian cancer risk.
A robust Kibria–Lukman estimator for linear regression model to combat multicollinearity and outliers
Authors: Majid Abdul , Ahmad Shakeel , Aslam Muhammad , Kashif Muhammad 
Published: November 2022

SummaryTo circumvent the problem of multicollinearity in regression models, a ridge‐type estimator is recently proposed in the literature, which is named as the Kibria–Lukman estimator (KLE). The KLE has better properties than the conventional ridge regression estimator. However, the presence of outliers in the data set may have some adverse effects on the KLE. To address this issue, the present article proposes a robust version of the KLE based on the M‐estimator. This article also proposes some robust methods to estimate the shrinkage parameter k. The Monte Carlo simulation study and a real‐life data is used to gauge the performance of the proposed methods where the mean squared error is used as the evaluation criterion. The numerical results witness the supremacy of the proposed estimator in the presence of outliers.
Decolonisation and anti‐racism: Challenges and opportunities for (teacher) education
Authors: Le Grange Lesley 
Published: November 2022

AbstractIn the past two decades, we have seen a renewed interest in decolonisation. A proliferation of literature produced on the topic, the establishment of journals on decolonisation, student protests such as the #RhodesMustFall campaign at universities in South Africa and Oxford University in Britain, French President Emmanuel Macron's call for the repatriation of African heritage from European museums, the appointment of a Deputy Minister of Decolonisation in Bolivia, bear testimony to a heightened consciousness on the topic. Moreover, we are witnessing the internationalisation of Indigenous knowledge as colonised peoples across the globe use the spaces that globalisation affords to build solidarities in order to resist the homogenising and normalising effects of globalisation and to decentre western epistemologies. In this article, which contributes to the Special Issue onDecolonial and Anti‐racist Perceptions in Teacher Training and Education Curricula, I do three things: discuss the concept of decolonisation including its meanings produced in different geographies, discuss the connection between decolonisation and anti‐racism, present challenges and opportunities for decolonising (teacher) education programmes through the concepts ofcurrere, complicated conversation and land education. I conclude that decolonisation is not an easy task in the neoliberal university and other institutions offering initial teacher training/education. However, there always exists opportunities for invigorating decolonial desires in such teaching/learning spaces.
Quantitative flow cytometry leveraging droplet‐based constriction microchannels with high reliability and high sensitivity
Authors: Yang Guang , Yang Hongyu , Zhang Ting , Gao Chiyuan , Chen Deyong , Wang Junbo , Chen Jian 
Published: November 2022

AbstractThis study presented a quantitative flow cytometry leveraging droplet‐based constriction microchannels with high reliability and high sensitivity. Droplets encapsulating single cells and even distribution of fluorescein labeled antibodies removed from targeted cells deformed through the constriction microchannel where the excited fluorescent signals were sampled and interpreted into numbers of proteins based on volume equivalence in measurement of droplets and calibration of fluorescence. To improve the detection reliability, a comprehensive analysis and comparison of multiple stripping agents such as proteinase K, guanidine hydrochloride, and urea was conducted. To improve the detection sensitivity, light modulation was used to address electrical noises and quartz microchannels were fabricated to address optical noises. As a demonstration, based on this quantitative flow cytometry of droplet microfluidics, (1) mutant p53 expressions of single cells were quantified as 1.95 ± 0.60 × 105 (ncell = 2918 of A431) and 1.30 ± 0.70 × 105 (ncell = 3954 of T47D); (2) single‐cell expressions of Ras, c‐Myc, and β‐tubulin were quantified as 1.90 ± 0.59 × 105, 4.39 ± 1.44 × 105, and 2.97 ± 0.81 × 105 (ncell = 3298 of CAL 27), 1.83 ± 0.58 × 105, 2.08 ± 0.13 × 106, and 1.96 ± 0.74 × 105 (ncell = 5459 of WSU‐HN6). As a microfluidic tool capable of quantitatively estimating single‐cell protein expressions, this methodology may provide a new quantitative perspective for the field of flow cytometry.
Early temperamental and biological predictors of dimensions of social withdrawal in childhood
Authors: Morneau‐Vaillancourt Geneviève , Ouellet‐Morin Isabelle , Pouliot Sandra , Poliakova Natalia , Feng Bei , Provost Lysandre , Forget‐Dubois Nadine , Matte‐Gagné Célia , Petitclerc Amélie , Brendgen Mara R. , Vitaro Frank , Tremblay Richard E. , Dionne Ginette , Boivin Michel 
Published: November 2022

AbstractSocial wariness and preference for solitude, two dimensions of social withdrawal, show unique associations with various socioemotional difficulties in childhood, including internalizing and peer problems. However, their early childhood predictors remain vastly undocumented. The present study aimed to examine whether early indicators of reactivity in situations of unfamiliarity such as behavioral inhibition, affect, and cortisol independently, or in interaction with emotion regulation as indexed by vagal tone, predict later social wariness and preference for solitude. Participants were 1209 children from the Quebec Newborn Twin Study. Vagal tone was assessed at 5 months, and behavioral inhibition, affect, and cortisol were assessed at 19 months in situations of unfamiliarity. Mothers, teachers, and peers evaluated social wariness and preference for solitude repeatedly from 4 to 10 years old. Findings show that three temperamental dimensions, social inhibition, nonsocial inhibition, and affect accounted for the variability in reactions to unfamiliarity. Behavioral inhibition to social unfamiliarity at 19 months predicted social wariness during the preschool years. Poor vagal regulation at 5 months exacerbated the risk associated with negative affect at 19 months to predict preference for solitude during the preschool years. Overall, results show that social wariness and preference for solitude may follow different developmental pathways.
Factor structure and psychometric properties of a multicultural Spanish‐language version of the Eating Disorder‐15 in a nonclinical sample of Chilean women
Authors: Compte Emilio J. , Cruzat‐Mandich Claudia , Pérez Ríos Leonardo , Vásquez Sofía , Gómez Nathalie , Trujillo‐ChiVacuan Eva 
Published: November 2022

AbstractObjectiveThe Eating Disorder‐15 (ED‐15) is a brief measure developed for the routine assessment of eating disorder (EDs), despite its use in research settings having increased over the last few years. To assess the psychometric properties of the ED‐15 in a nonclinical sample of Chilean women.MethodA multicultural Spanish‐language version was developed through combined translation techniques. University female students (N = 380) (Mage 22.32, SD = 2.48) were recruited through social media. After providing their informed consent, participants completed a battery of questionnaires online.ResultsA bi‐factor model replicating the bi‐factor structure and providing support for the general factor showed the best fit to the data. Moderate‐to‐strong correlations with measures of EDs, physical comparison, body appreciation, social physique anxiety, and depressive symptoms are presented as evidence of concurrent and convergent validity. Items analyses revealed strong correlations between manifest variables, their correspondent latent variable and the general factor (rs = .60 to .89, ps < .001). Additionally, current findings provide support for the internal consistency of the scale (Cronbach's alpha and Omega values were ≥ .80) and test–retest reliability (ICCs = .84 to .89, ps < .001).DiscussionLike previous findings, the current study provides validity to the original bi‐factor structure of the ED‐15 and additional validity to a general factor. The availability of this multicultural Spanish‐language version would provide session‐by‐session assessment, providing crucial information throughout treatment. Also, the availability of the current measure would contribute to further research efforts in a yet understudied population such as Hispanic women.Public SignificanceThe Eating Disorder‐15 (ED‐15) is a promising measure meant to assess session‐by‐session change for clinical and research purposes. The availability of a Multicultural Spanish language version of the ED‐15 allows for routine clinical assessment and represents a contribution for research efforts in a yet understudied populations such as Hispanic women.
Economic pressures of Covid‐19 lockdowns result in increased timber extraction within a critically endangered region: A case study from the Pacific Forest of Ecuador
Authors: Tleimat Jacquelyn M. , Fritts Sarah R. , Brunner Rebecca M. , Rodriguez David , Lynch Ryan L. , McCracken Shawn F. 
Published: November 2022

AbstractAlthough the COVID‐19 lockdowns in 2020 had some environmental benefits, the pandemic's impact on the global economy has also had conservation repercussions, especially in biodiverse nations. Ecuador, which is heavily reliant on petroleum, agricultural exports, and ecotourism, experienced a rise in poverty in response to pandemic shutdowns. In this study, we sought to quantify levels of illegal timber extraction and poaching before and after the start of COVID‐19 lockdowns throughout two protected areas (Reserva Jama Coaque [JCR] and Bosque Seco Lalo Loor [BSLL]) in the endangered Pacific Forest of Ecuador. We analyzed chainsaw and gunshot acoustic data recorded from devices installed in the forest canopy from December 2019 to March 2020 and October 2020 to March 2021. Results from generalized linear mixed effects models indicated less chainsaw activity before lockdowns (βpost.lockdown = 0.568 ± 0.266 SE, p‐value = .030), although increased average rainfall also seemed to negatively affect chainsaw activity (βavg.rainfall = −0.002 ± 0.0006 SE, p‐value = .003). Gunshots were too infrequent to conduct statistical models; however, 87% of gunshots were detected during the ‘lockdown’ period. Observational data collected by rangers from these protected areas also noted an increase in poaching activities beginning mid to late 2020 and persisting into 2021. These results add to the steadily growing literature indicating an increase in environmental crime, particularly in biodiverse nations, catalyzed by COVID‐19‐related economic hardships. Identifying areas where environmental crime increased during pandemic lockdowns is vital to address both socioeconomic drivers and enforcement deficiencies to prevent further biodiversity loss and disease outbreaks and to promote ecosystem resilience. Our study also demonstrates the utility of passive acoustic monitoring to detect illegal resource extraction patterns, which can inform strategies such as game theory modeling for ranger patrol circuits and placement of real‐time acoustic detection technologies to monitor and mitigate environmental crimes.
Effects of a nuclear power plant warmwater outflow on environmental conditions and fish assemblages in a very large river (the Danube, Hungary)
Authors: Füstös Vivien , Sály Péter , Szalóky Zoltán , Tóth Balázs , Vitál Zoltán , Specziár András , Fleit Gábor , Baranya Sándor , Józsa János , Erős Tibor 
Published: November 2022

AbstractDirect or indirect effects of nuclear power plants' (NPPs) warmwater effluents on the structure of biotic assemblages are poorly known in very large rivers. We examined changes in physical habitat structure, temperature condition and their possible effects on the structure of Danubian fish assemblages due to the outflow of the Paks NPP's warmwater channel, in Hungary. Seasonal surveys conducted both upstream and downstream from the outfall showed that its hydromorphological effects were generally local and comparable to natural or other anthropogenic hydromorphological changes. The effect of the returned cooling water was more apparent in the seasonally recorded surface water temperatures and depended highly on the spatial positioning of the sampling sites. However, environmental and spatial variables accounted only for a low amount of variance in case of both shoreline and offshore fish assemblage data. Overall, we found that the outflow exerted only a local scale effect on the structure of Danubian fish assemblages. Rather, fish assemblages varied largely both inshore and offshore, which dynamics overruled any effects of the artificially elevated temperature. Our study highlights the importance of the assessment of hydrogeomorphological variability of rivers and their influence on fish assemblage variability when examining spatial effects of thermal pollution.
Sampling bias and the robustness of ecological metrics for plant–damage‐type association networks
Authors: Swain Anshuman , Azevedo‐Schmidt Lauren E. , Maccracken S. Augusta , Currano Ellen D. , Dunne Jennifer A. , Labandeira Conrad C. , Fagan William F. 
Published: November 2022

AbstractPlants and their insect herbivores have been a dominant component of the terrestrial ecological landscape for the past 410 million years and feature intricate evolutionary patterns and co‐dependencies. A complex systems perspective allows for both detailed resolution of these evolutionary relationships as well as comparison and synthesis across systems. Using proxy data of insect herbivore damage (denoted by the damage type or DT) preserved on fossil leaves, functional bipartite network representations provide insights into how plant–insect associations depend on geological time, paleogeographical space, and environmental variables such as temperature and precipitation. However, the metrics measured from such networks are prone to sampling bias. Such sensitivity is of special concern for plant–DT association networks in paleontological settings where sampling effort is often severely limited. Here, we explore the sensitivity of functional bipartite network metrics to sampling intensity and identify sampling thresholds above which metrics appear robust to sampling effort. Across a broad range of sampling efforts, we find network metrics to be less affected by sampling bias and/or sample size than richness metrics, which are routinely used in studies of fossil plant–DT interactions. These results provide reassurance that cross‐comparisons of plant–DT networks offer insights into network structure and function and support their widespread use in paleoecology. Moreover, these findings suggest novel opportunities for using plant–DT networks in neontological terrestrial ecology to understand functional aspects of insect herbivory across geological time, environmental perturbations, and geographic space.
A multispecies, intraspecific functional traits data set on fish species from the Bay of Biscay, France
Authors: Rozanski Romane , Eme David , Boiron Leroy Anne , Rufino Marta M. , Albouy Camille 
Published: November 2022

AbstractThe global biodiversity crisis due to anthropogenic pressures jeopardizes marine ecosystem functioning and services. Community responses to these environmental changes can be assessed through functional diversity, a biodiversity component related to organism–environment interactions, and estimated through biological traits related to organism functions (locomotion, feeding mode, and reproduction). Fish play a key role in marine systems functioning and supply proteins for billions of humans worldwide, yet most of the knowledge is limited to several commercial species and little is known about the intraspecific variability of their functional traits. The data provided here consist of 867 records of individuals from 85 species of ray‐finned (Actinopterygii) and cartilaginous (Chondrichthyes) fish sampled in the Bay of Biscay (Atlantic, France) between autumn 2017 and 2019. We provided for each individual the taxonomic classification, 16 ecomorphological measures (5 directly made on fresh individuals and 11 realized using individual pictures) that were converted into nine ecomorphological traits classically documented in the literature (biomass, protrusion, oral gape shape, surface and position, eye size and position, body transversal shape and surface, pectoral fin position and caudal peduncle throttling) and eight life history traits obtained from FishBase (maximum length, average depth, depth range, trophic level, reproduction mode, fertilization mode, parental care, vertical position in the water column). These traits document several functions such as dispersion, feeding mode, habitat use, position in the food web, and reproduction. To improve the development of new traits, we provided a picture of each individual with an ROI file containing the different morpho‐anatomical measures made using “ImageJ” software and an R function to extract them. In addition, we provided the metadata from each sampling site (years, dates, stations, sampling hours, strata, gears, latitudes, longitudes, and depths) and environmental variables measured in situ (conductivity, salinity, water temperature, water density, and air temperature). This data set accounting for the intraspecific variability among 85 fish species is of interest to better understand the effects of environmental forcing in a global change context as in the Bay of Biscay, a highly fished transition zone harboring mixed assemblages of boreal, temperate, and subtropical fish species that are susceptible to display variability in functional trait to adapt to changing conditions. The data set is freely available without copyright restrictions; users should cite this paper in research products (publications, presentations, reports, etc.) derived from the data set.