bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of regulated add‐on sodium chloride intake on stabilization of serum lithium concentration in bipolar disorder: A randomized controlled trial
Authors: George Seena , Maiti Rituparna , Mishra Biswa Ranjan , Jena Monalisa , Mohapatra Debadatta 
Published: November 2022

AbstractObjectiveLithium‐induced natriuresis may lead to lithium retention and fluctuation of lithium levels during maintenance therapy. Therefore, the present study was conducted to evaluate the effect of add‐on sodium chloride on serum lithium levels in bipolar disorder.MethodsThis RCT was conducted in 60 patients with type I bipolar disorder who were randomized into the control group that received lithium carbonate with the advice not to take additional salt (at the table) and the test group that received sachets of sodium chloride (1 g/d) as an add‐on to lithium carbonate and were advised to restrict their additional salt intake (at the table) to 1 g/d. After baseline assessments, all patients were followed up at 4 weeks, 8 weeks, and 12 weeks when serum lithium, sodium, and potassium were estimated. Serum creatinine and aldosterone were repeated at 12 weeks. The percentage of patients showing fluctuations in serum lithium level (serum lithium <0.6 mEq/L or >0.8 mEq/L) was considered as the primary outcome measure.ResultsIn the test group, the fluctuation rate in serum lithium (26.7%) was significantly (p = 0.01) lower than that in the control group (63.3%). Serum lithium values varied significantly across sampling times in the control group but not in the test group. There was a significant difference in serum lithium between the groups at 8 and 12 weeks of follow‐up. There were no significant differences in the change in serum sodium, potassium, creatinine, aldosterone, creatinine clearance, and blood pressure within the group and between the groups. A significant positive correlation was found between serum lithium and aldosterone at baseline.ConclusionsIntake of add‐on sodium chloride (1 gm/day) may reduce the fluctuations in serum lithium during the maintenance phase of lithium therapy in type I bipolar disorder.ClinicalTrial.gov IdentifierNCT04222816.
Discussion on: Instrumented Difference-in-Differences, by Ting Ye, Ashkan Ertefaie, James Flory, Sean Hennessy and Dylan S. Small
Authors: DiazOrdaz Karla 
Published: November 2022

Abstract
I discuss the assumptions needed for identification of average treatment effects and local average treatment effects in instrumented difference-in-differences (IDID), and the possible trade-offs between assumptions of standard IV and those needed for the new proposal IDID, in one- and two-sample settings. I also discuss the interpretation of the estimands identified under monotonicity. I conclude by suggesting possible extensions to the estimation method, by outlining a strategy to use data-adaptive estimation of the nuisance parameters, based on recent developments.
ABRACADABRA literacy instruction for children with Down syndrome via telepractice during COVID‐19: A pilot study
Authors: Murphy Annemarie , Bailey Benjamin , Arciuli Joanne 
Published: November 2022

AbstractBackgroundCOVID‐19 has resulted in some educators and allied health practitioners transitioning to online delivery of literacy instruction. As far as we are aware, no studies have investigated online delivery of comprehensive literacy instruction for children with Down syndrome.AimsIn this pilot study, we explore the efficacy of online delivery of ABRACADABRA (a free literacy web application) for children with Down syndrome, alongside supplementary parent‐led shared book reading, during the COVID‐19 pandemic.SampleSix children with Down syndrome, aged 8–12 years, participated in this within‐participants design study.MethodsParticipants acted as their own controls with outcome variables measured at three timepoints: baseline, pre‐instruction and post‐instruction. Children participated in 16–18 hrs of one‐to‐one literacy instruction online over a 6‐week instruction phase, along with twice weekly parent‐led shared book reading activities.ResultsOutcomes from standardized assessments revealed statistically significant improvements in word‐ and passage‐level reading accuracy skills over the instruction phase (pre‐instruction to post‐instruction) compared with the no‐instruction control phase (baseline to pre‐instruction). Improvements in reading comprehension skills were inconsistent across assessment measures and statistical analyses.ConclusionChildren with Down syndrome can benefit from comprehensive literacy instruction delivered via telepractice. Our study provides critical initial evidence of successful service delivery during a global pandemic and beyond.
Policy shops, hired guns, and gatekeepers: The organization and distribution of policy analysts in Ontario
Authors: Migone Andrea , Howlett Michael 
Published: November 2022

AbstractPolicy professionals play an important role in political and administrative systems. However, the exact configuration and distribution of such personnel within agencies remains largely unknown. Early works noted the creation of small dedicated “policy shops” in many governments after 1960 where many policy professionals were located. Studies in Canada and elsewhere subsequently confirmed this organizational form but questions such as how many professionals are employed and where these units are located within existing departmental structures remain opaque. In this article, we provide an organizational mapping of professional policy personnel in the Ontario Public Service (OPS). We find that four major personnel distribution patterns exist within the OPS with only some analysts and professionals working in “classical” policy shops. These findings underscore the need to re‐evaluate the organization and staffing of professional policy analysts in government in order to better account for the kinds of work policy professionals do in modern administrations.
Salviolone protects against high glucose‐induced proliferation, oxidative stress, inflammation, and fibrosis of human renal mesangial cells by upregulating membrane metalloendopeptidase expression
Authors: Wang Xichao , Song Ruili , Li Zhuo 
Published: November 2022

AbstractAs one of complications of diabetes mellitus, diabetic nephropathy is related to renal dysfunction. Membrane metalloendopeptidase (MME) is associated with the pathogenesis of diabetic nephropathy and exerts a protective function in high glucose (HG)‐treated podocytes. Salviolone, one of important bioactive components from Salvia miltiorrhiza, possesses an anti‐inflammatory activity. However, the roles of salviolone in renal mesangial cell dysfunction under HG condition remain unknown. The targets of salviolone in diabetic nephropathy were predicted by bioinformatics analysis. Relative mRNA level of MME was detected by qPCR in HG‐treated human renal mesangial cells (HRMCs). Cell viability was analyzed using CCK‐8 assay. Cell proliferation was investigated by EdU staining. Oxidative stress was evaluated by detection of ROS generation and levels of oxidative stress‐related biomarkers. The inflammatory cytokines and fibrosis‐related biomarkers were examined by ELISA. Our results showed that MME expression was decreased in diabetic nephropathy and HG‐treated HRMCs. Salviolone increased MME level in HG‐treated HRMCs. Salviolone mitigated HG‐induced HRMC proliferation by increasing MME expression. Salviolone attenuated HG‐induced ROS generation, MDA level increase, and SOD activity decrease through upregulating MME expression. Moreover, salviolone suppressed HG‐induced increase of levels of TNF‐α, IL‐1β, IL‐6, fibronectin, and collagen IV through upregulating MME expression. In conclusion, salviolone attenuates proliferation, oxidative stress, inflammation, and fibrosis in HG‐treated HRMCs through upregulating MME expression.
Staging Arts in the Historic City: Development Funding, Social Media Images, and Tunisia's Contemporary Public Art Scene
Authors: Malachowski Justin 
Published: November 2022

AbstractIn this paper, I examine how public art projects in the Medina of Tunis “stay in the game,” a reference to the (social) media management strategies that projects pursue to attract and keep funding. Following the 2011 “Arab Spring,” revolution, known locally as the thawra, a vibrant public art scene has formed centered in the Medina of Tunis, the highly visible but economically marginalized historic center of the city of Tunis. The formation of this public art scene is due largely to a post‐revolution influx of foreign development funding. The public art scene in the Medina of Tunis, bolstered by social media, has been widely articulated as providing visibility to marginalized communities through participatory methods. I argue that this claim paradoxically obscures the diverse lifestyles and imaginaries of the communities that public art projects aim to benefit. This paradox is rooted in both a history of mediating the historic city as an image of a modern nation, and public art's dependency on foreign funding, which draws it into maintaining foreign neoliberal interests while expressing these interests as essentially local. Meanwhile, improvements in the material conditions for residents of the Medina, expressed in terms of mirtah(comfort), remain elusive.
Immigration and economic freedom of the US states: Does the institutional quality of immigrants' origin countries matter?
Authors: Padilla Alexandre , Cachanosky Nicolás 
Published: November 2022

AbstractWhen people immigrate to the United States from countries with less economic freedom, they do not dampen economic freedom in their destination states. We use the Economic Freedom of North America report to rate the economic freedom of US states, and we group immigrants by how far below the United States their origin countries score in the Economic Freedom of the World report. Our major findings hold true even when states receive immigrants from countries with far less economic freedom. Most relationships between immigration and the US states' economic freedom scores are neither statistically nor economically significant.
Detailed investigation of multiple resting cardiovascular parameters in relation to physical fitness
Authors: Lind Lars , Michaëlsson Karl 
Published: November 2022

AbstractObjectiveMaximal oxygen consumption at an exercise test (VO2‐max) is a commonly used marker of physical fitness. In the present study, we aimed to find independent clinical predictors of VO2‐max by use of multiple measurements of cardiac, respiratory and vascular variables collected while resting.MethodsIn the Prospective study of Obesity, Energy and Metabolism (POEM), 420 subjects aged 50 years were investigated regarding endothelial function, arterial compliance, heart rate variability, arterial blood flow and atherosclerosis, left ventricular structure and function, lung function, multiple blood pressure measurements, lifestyle habits, body composition and in addition a maximal bicycle exercise test with gas exchange (VO2 and VCO2).ResultsWhen VO2‐max (indexed for lean mass) was used as the dependent variable and the 84 hemodynamic or metabolic variables were used as independent variables in separate sex‐adjusted models, 15 variables showed associations with p < 0.00064 (Bonferroni‐adjusted). Eight independent variables explained 21% of the variance in VO2‐max. Current smoking and pulse wave velocity (PWV) were the two major determinants of VO2‐max (explaining each 7% and 3% of the variance; p < 0.0001 and p = 0.008, respectively). They were in order followed by vital capacity, fat mass, pulse pressure, and high‐density lipoprotein (HDL)‐cholesterol. The relationships were inverse for all these variables, except for vital capacity and HDL.ConclusionSeveral metabolic, cardiac, respiratory and vascular variables measured at rest explained together with smoking 21% of the variation in VO2‐max in middle‐aged individuals. Of those variables, smoking and PWV were the most important.
Nestin+ Peyer's patch resident MSCs enhance healing of inflammatory bowel disease through IL‐22‐mediated intestinal epithelial repair
Authors: Chen Jieying , Huang Jing , Shi Jiahao , Li Minrong , Zhao Erming , Li Gang , Chen Xiaoyong , Wang Tao , Li Qiaojia , Li Weiqiang , Ma Jianping , Mao Wenzhe , Fang Rui , Hao Jiang , Huang Weijun , Xiang Andy Peng , Zhang Xiaoran 
Published: November 2022

AbstractInflammatory bowel disease (IBD) is a chronic condition characterized by gastrointestinal tract inflammation and still lacks satisfactory treatments. Mesenchymal stromal cells (MSCs) show promising potential for treating IBD, but their therapeutic efficacy varies depending on the tissue of origin. We aim to investigate whether intestine Peyer's patch (PP)‐derived MSCs have superior immunomodulatory effects on T cells and better therapeutic effects on IBD compared with bone marrow‐derived MSCs. We isolated PPs‐derived Nestin+ MSCs (MSCsPP) and bone marrow‐derived Nestin+ MSCs (MSCsBM) from Nestin‐GFP transgenic mice to explore their curative effects on murine IBD model. Moreover, we tested the effects of IL‐22 knockdown and IL‐22 overexpression on the therapeutic efficacy of MSCsPP and MSCsBM in murine IBD, respectively. We demonstrated that Nestin+ cells derived from murine PPs exhibit MSC‐like biological characteristics. Compared with MSCsBM, MSCsPP possess enhanced immunoregulatory ability to suppress T cell proliferation and inflammatory cytokine production. Moreover, we observed that MSCsPP exhibited greater therapeutic efficacy than MSCsBM in murine IBD models. Interestingly, IL‐22, which was highly expressed in MSCsPP, could alleviate the severity of the intestinal inflammation, while knockdown IL‐22 of MSCsPP remarkably weakened the therapeutic effects. More importantly, IL‐22 overexpressing MSCsBM could significantly improve the symptoms of murine IBD models. This study systemically demonstrated that murine MSCsPP have a prominent advantage in murine IBD treatment, partly through IL‐22.
Retinopathy of prematurity
Authors: Dammann Olaf , Hartnett M. Elizabeth , Stahl Andreas 
Published: November 2022

AbstractRetinopathy of prematurity (ROP) is a devastating neurovascular disease of the retina in newborn infants that can lead to vision deficits or even blindness. In this concise review we discuss our current knowledge about diagnosis, etiology, pathogenesis, intervention, and outcomes of the disease. Major advancements have been made both in categorizing the disease in the new International Classification of Retinopathy of Prematurity, Third Edition classification and in treating severe ROP with anti‐vascular endothelial growth factor (VEGF) agents. New development always creates new questions and opens up new areas of research. We will discuss in this review both the benefits and downsides of the new anti‐VEGF treatment approaches in ROP, especially in light of our improved understanding of the underlying ROP pathophysiology. We also offer pointers to areas where more research is needed.What this paper adds

Concise update on all aspects of retinopathy of prematurity (ROP), including advances in understanding and treatment.
Benefits and risks of the new treatment method of anti‐vascular endothelial growth factor injections in ROP are discussed.
New research areas that deserve attention in the coming years are identified.
Gross motor change after inpatient rehabilitation for children with acquired brain injury: A 10‐year retrospective review
Authors: Ryan Jennifer L. , Zhou Chuanlin , Levac Danielle E. , Fehlings Darcy L. , Beal Deryk S. , Hung Ryan , Wright F. Virginia 
Published: November 2022

AbstractAimTo estimate gross motor change in inpatient school‐aged children with subacute acquired brain injury (ABI), identify factors associated with gross motor change, and describe inpatient physiotherapy focus.MethodThis retrospective chart review involved inpatient children (5–18 years) with subacute ABI who had either two Gross Motor Function Measure (GMFM‐88) assessments or one GMFM‐88 with another pre/post gross motor outcome measure. Outcome change scores and Goal Attainment Scaling (GAS) T scores were calculated. Regression analyses examined factors predicting gross motor change. GAS goal areas were analysed to determine physiotherapy focus.ResultsOf the 546 charts screened, 266 (118 female) met study criteria. The GMFM‐88 was generally administered first, followed by other measures. GMFM‐88 (n = 202), Community Balance and Mobility Scale (n = 89), and Six‐Minute Walk Test (6MWT) (n = 98) mean change scores were 18.03% (SD 19.34), 17.85% (SD 10.77), and 142.3 m (SD 101.8) respectively. The mean GAS T score was 55.06 (SD 11.50). Lower baseline scores and increased time between assessments were most predictive of greater GMFM‐88 change (r ≥ 0.40). Twenty‐five percent of GAS goals were ambulation‐based.InterpretationAppropriate outcome measure selection is integral to detecting gross motor change in pediatric inpatient ABI rehabilitation. Mean change score estimates can be used to compare standard inpatient rehabilitation with new treatment approaches.
Clinical utility of intraoperative electrocorticography for epilepsy surgery: A systematic review and meta‐analysis
Authors: Goel Keshav , Pek Valérie , Shlobin Nathan A. , Chen Jia‐Shu , Wang Andrew , Ibrahim George M. , Hadjinicolaou Aristides , Roessler Karl , Dudley Roy W. , Nguyen Dang K. , El‐Tahry Riëm , Fallah Aria , Weil Alexander G. 
Published: November 2022

AbstractDespite the widespread use of intraoperative electrocorticography (iECoG) during resective epilepsy surgery, there are conflicting data on its overall efficacy and inability to predict benefit per pathology. Given the heterogeneity of iECoG use in resective epilepsy surgery, it is important to assess the utility of interictal‐based iECoG. This individual patient data (IPD) meta‐analysis seeks to identify the benefit of iECoG during resective epilepsy surgery in achieving seizure freedom for various pathologies. Embase, Scopus, and PubMed were searched from inception to January 31, 2021 using the following terms: "ecog", "electrocorticography", and "epilepsy". Articles were included if they reported seizure freedom at ≥12‐month follow‐up in cohorts with and without iECoG for epilepsy surgery. Non‐English articles, noncomparative iECoG cohorts, and studies with <10% iECoG use were excluded. This meta‐analysis followed the PRISMA 2020 guidelines. The primary outcome was seizure freedom at last follow‐up and time to seizure recurrence, if applicable. Forest plots with random effects modeling assessed the relationship between iECoG use and seizure freedom. Cox regression of IPD was performed to identify predictors of longer duration of seizure freedom. Kaplan–Meier curves with log‐rank test were created to visualize differences in time to seizure recurrence. Of 7504 articles identified, 18 were included for study‐level analysis. iECoG was not associated with higher seizure freedom at the study level (relative risk = 1.09, 95% confidence interval [CI] = 0.96–1.23,p = .19,I2 = 64%), but on IPD (n = 7 studies, 231 patients) iECoG use was independently associated with more favorable seizure outcomes (hazard ratio = 0.47, 95% CI = .23–.95,p = .037). In Kaplan–Meier analysis of specific pathologies, iECoG use was significantly associated with longer seizure freedom only for focal cortical dysplasia (FCD;p < .001) etiology. Number needed to treat for iECoG was 8.8, and for iECoG in FCD it was 4.7. We show iECoG seizure freedom is not achieved uniformly across centers. iECoG is particularly beneficial for FCD etiology in improving seizure freedom.
Biomedical knowledge graph embeddings for personalized medicine: Predicting disease‐gene associations
Authors: Vilela Joana , Asif Muhammad , Marques Ana Rita , Santos João Xavier , Rasga Célia , Vicente Astrid , Martiniano Hugo 
Published: November 2022

AbstractPersonalized medicine is a concept that has been subject of increasing interest in medical research and practice in the last few years. However, significant challenges stand in the way of practical implementations, namely in regard to extracting clinically valuable insights from the vast amount of biomedical knowledge generated in the last few years. Here, we describe an approach that uses Knowledge Graph Embedding (KGE) methods on a biomedical Knowledge Graph (KG) as a path to reasoning over the wealth of information stored in publicly accessible databases. We built a Knowledge Graph using data from DisGeNET and GO, containing relationships between genes, diseases and other biological entities. The KG contains 93,657 nodes of 5 types and 1,705,585 relationships of 59 types. We applied KGE methods to this KG, obtaining an excellent performance in predicting gene‐disease associations (MR 0.13, MRR 0.96, HITS@1 0.93, HITS@3 0.99, and HITS@10 0.99). The optimal hyperparameter set was used to predict all possible novel gene‐disease associations. An in‐depth analysis of novel gene‐disease predictions for disease terms related to Autism Spectrum Disorder (ASD) shows that this approach produces predictions consistent with known candidate genes and biological pathways and yields relevant insights into the biology of this paradigmatic complex disorder.
Better together: Relationship quality and mental health among cardiac patients and spouses
Authors: Bouchard Karen , Gareau Alexandre , Sztajerowska Karolina , Greenman Paul S. , Lalande Kathleen , Tulloch Heather 
Published: November 2022

AbstractReductions in marital relationship quality are pervasive post‐cardiac event. It is not yet understood how relationship quality is linked to mental health outcomes in couples where one member has established cardiovascular disease (CVD) and the interdependence within dyads is seldom measured. This research is required as psychological distress has been independently linked to CVD incidence, morbidity, and mortality. This study assessed associations of relationship quality with depression and anxiety among patients with CVD and their spouses. Participants completed questionnaires measuring four dimensions of relationship quality and mental health. Data were analyzed using an Actor‐Partner Interdependence Model with hierarchical moderation analyses. 181 dyads (N = 362 participants) comprised the study sample. Most patients had coronary artery disease (66.3%) and 25.9% were female. Patients reported higher relationship satisfaction and fewer anxiety symptoms than did spouses. Patients and spouses with high dyadic consensus and affectional expression reported fewer mental health symptoms, but only when the other partner also perceived high levels of consensus and affectional expression in the relationship. Patients and spouses with low dyadic cohesion reported worse mental health symptoms (actor effects), but those effects were no longer significant when both the patient and the spouse appraised the relationship as having high levels of dyadic cohesion. Taken together, relationship quality is linked to mental health symptoms in patients with CVD and their spouses. Longitudinal and experimental studies are now warranted to further substantiate the cross‐sectional findings of this study.