bluuebunny/crossref_metadata_2025_split huggingface dataset:
Recent Evolution of Glaciers in the Manaslu Region of Nepal From Satellite Imagery and UAV Data (1970–2019)
Authors: Racoviteanu Adina E. , Glasser Neil F. , Robson Benjamin A. , Harrison Stephan , Millan Romain , Kayastha Rijan B. , Kayastha Rakesh 
Published: April 2022

Glacierized mountain ranges such as the Himalaya comprise a variety of glacier types, including clean and debris-covered glaciers. Monitoring their behaviour over time requires an assessment of changes in area and elevation along with surface features and geomorphology. In this paper we quantify the surface evolution of glacier systems in the Manaslu region of Nepal over the last five decades using 2013/2019 multi-sensor imagery and elevation data constructed from 1970 declassified Corona imagery and 1970 declassified Corona imagery. We investigate area changes, glacier thickness, geodetic glacier mass balance and surface velocity changes at regional scales and focus on the Ponkar Glacier and Thulagi Glacier and Lake for an in-depth assessment of surface geomorphology and surface feature dynamics (ponds, vegetation and ice cliffs). The time series of surface elevation changes for the lower ablation area of Ponkar Glacier is extended using 2019 UAV-based imagery and field-based ablation rates measured over the period 2016–2019. Glaciers in the Manaslu region experienced a mean area loss of −0.26 ± 0.0001% a−1 between 1970 and 2019. The mean surface lowering was −0.20 ± 0.02 ma−1 over the period 1970 to 2013, corresponding to a regional geodetic mass balance of −0.17 ± 0.03 m w. e.a−1. Overall, debris-covered glaciers had slightly higher thinning rates compared to clean ice glaciers; lake-terminating glaciers had double thinning rates compared to land-terminating glaciers. Individual glacier mass balance was negatively controlled by glacier slope and mean glacier elevation. During the period 1970 to 2013, Ponkar Glacier had a geodetic mass balance of −0.06 ± 0.01 m w. e.a−1, inversely correlated with parts of the central trunk thickening. Between 2013 and 2019 there was a nine-fold increase in the thinning rates over the lower parts of the glacier tongue relative to the period 1970–2013. Ice-surface morphology changes between 1970 and 2019 on Ponkar Glacier include a decrease in ogives and open crevasses, an increase in ice cliffs and ponds and the expansion of the supraglacial debris and ice-surface vegetation. These changes point to reduced ice-dynamic activity and are commensurate with the observed recession and negative glacier mass balance over the last five decades.
Holocene Environmental Dynamics of the Lago Cochrane/Pueyrredón Valley, Central West Patagonia (47°S)
Authors: Maldonado Antonio , de Porras María Eugenia , Martel-Cea Alejandra , Reyes Omar , Nuevo-Delaunay Amalia , Méndez César 
Published: April 2022

Deglaciation modeling of the Patagonian Ice Field since the Last Glacial Maximum has been a topic of intensive research in Central West Patagonia (44°–49°S). However, the chronology of deglaciation onset, acceleration, and the subsequent thinning and recession of the different ice lobes as well as the timing and extension of large proglacial systems are still a matter of discussion. The maximum eastward extension the Lago Cochrane/Pueyrredón ice lobe was around ∼20,000–27,000 cal yrs BP; its associated proglacial lake drained toward the Pacific between 12,600 and 8,000 cal yrs BP. This study presents the first two pollen and charcoal records from the Lago Cochrane/Pueyrredón valley, spanning the last 11,650 cal yrs BP. The Laguna Maldonado record spans between 11,650 and 8,500 cal yrs BP, while the Laguna Anónima record the last 8,500 cal yrs BP, thereby overlapping chronologically. The lithological record of Laguna Maldonado shows that organic sedimentation began at the onset of the Holocene (11,650 cal yrs BP), once the site was free of glacio-lacustrine influence. Between 11,650 and 10,500 cal yrs BP, an open Nothofagus forest developed associated with high fire occurrence/frequency, followed by a transitional phase to a closer forest associated with a shift from low to high fire activity up to 9,400 cal yrs BP. Between 9,400 and 8,500 cal yrs BP, the Laguna Maldonado record suggests the development of an open forest or probably scattered patches of forest of variable size in a steppe matrix, probably related to geomorphological and paraglacial dynamics as well as climatic forcings, while the Laguna Anónima record indicates the development of a closed Nothofagus forest and high to low fire occurrence/frequency from 8,200 to 3,800 cal yrs BP. Since 3,800 cal yrs BP, a highly dynamic open forest or forest patches scattered in a grass/shrub–grass steppe matrix occurred around Laguna Anónima associated with high fire occurrence/frequency synchronous with an important increase in the presence of hunter-gatherers during the last 3,000 years. The results from the Lago Cochrane/Pueyrredón valley are integrated and discussed at the regional scale alongside other records from Central West Patagonia.
Optimization of Re-Fracturing Method and Fracture Parameters for Horizontal Well in Mahu Conglomerate Oil Reservoir
Authors: Yi Yonggang , Wang Lei , Li Jie , Chen Sen , Tian Hui , Tian Gang 
Published: April 2022

Mahu Oilfield, the largest conglomerate oilfield around the world, is facing the severe problems of rapid production decline and low recovery ratio. Re-fracturing of horizontal wells is an effective method to improve this situation. The study of horizontal well re-fracturing has increased popularity recently, but the optimization of re-fracturing parameters has not been thoroughly investigated, especially for the conglomerate reservoir. The optimal selection of re-fracturing parameters such as length and conductivity is unclear, which significantly influences re-fracturing treatment and economic cost. In order to fill this gap, a series of numerical models are established based on filed data to predict horizontal well production after re-fracturing. The parameters of primary hydraulic fractures are calculated by net pressure matching and are imported into the numerical models. A production matching is conducted to confirm the reliability of numerical models. The cumulative productions of different re-fracturing stimulation methods, including lengthening old fractures and perforating new fractures, are simulated, and the corresponding re-fracturing parameters are optimized. The results have shown that the length of primary fractures is smaller than designed, which means lengthening old fractures is necessary. Lengthening old fractures and perforating new fractures between primary clusters can increase production. On the condition of the same fracture length, the increasing ranges of production corresponding to perforating new fractures are larger than that of lengthening old fractures. Lengthening old fractures is particularly suitable to the situation that the length of primary fractures is smaller than designed, and the optimal value in lengthening half-length of old fractures is 160 m. By contrast, perforating new fractures between old clusters applies to the case that the cluster spacing of primary hydraulic fracturing is larger than 35 m, and the optimal fracture half-length is 140 m.
Prevalence of Hemoglobin-S and Baseline Level of Knowledge on Sickle Cell Disease Among Pregnant Women Attending Antenatal Clinics in Dar-Es-Salaam, Tanzania
Authors: Tutuba Hilda J. , Jonathan Agnes , Lloyd William , Luoga Fredrick , Marco Emanuela , Ndunguru Joyce , Kidenya Benson R. , Makani Julie , Ruggajo Paschal , Minja Irene K. , Balandya Emmanuel 
Published: April 2022

Background: Sickle cell disease (SCD) is the single most important genetic cause of childhood mortality globally. Newborn screening (NBS) is the recommended intervention aimed at early identification of babies with SCD and their linkage to care. To ensure success of NBS, pregnant women need to have the required knowledge on SCD and therefore motivation to screen their babies.Objective: The aim of this study was to determine the prevalence of hemoglobin-S and assess the baseline level of knowledge on SCD among pregnant women attending antenatal clinics in urban settings in Dar-es-Salaam, Tanzania.Methods: This cross-sectional study was conducted between August 2020 and February 2021, involving 600 pregnant women at 20–28 weeks of gestation attending antenatal clinics at Buguruni Health Center, Mbagala Hospital, and Sinza Hospital in Dar-es-Salaam, Tanzania. We administered a structured questionnaire to all participants to assess socio-demographic characteristics and baseline level of knowledge on SCD, where those scoring 7 or higher out of 10 questions were considered to have good knowledge. We screened for SCD a total of 300 participants from two centers (Buguruni Health Center and Mbagala Hospital) by using Sickle SCAN point-of-care test (BioMedomics Inc., United States). We used SPSS version 23 to analyze the data. On determining the association between level of knowledge and socio-demographic factors, we used Pearson’s Chi-square and multivariate logistic regression in ascertaining the strength of associations.Results: Of the 600 participants, the majority were of the age between 26 and 35 years (51%), with the parity of 1-3 children (55.8%) and secondary level of education (43%), while 56% were self-employed. Only 14.7% had good knowledge on SCD. The majority of the participants had ever heard of SCD (81.3%), most of them heard from the streets (42.4%), and only 2.4% heard from hospitals. Of all 600 study participants, only 2 (0.3%) knew their SCD status while 7.7% declared having a family history of SCD. A proficient level of knowledge on SCD is associated with a high level of education, occupation, and knowing personal status of SCD. Among 300 participants who were screened for SCD, 252 were Hb-AA (84%), 47 were Hb-AS (15.7%), and 1 (0.3%) was Hb-SS.Conclusion: Despite the high prevalence of hemoglobin-S among pregnant women attending antenatal clinics in urban settings in Tanzania, there is a poor level of knowledge on SCD and personal knowledge of SCD status. Maternal screening and health education on SCD should be included as part of the comprehensive package for health promotion at antenatal clinics.
Case Report: Atypical Manifestations Associated With FOXP3 Mutations. The “Fil Rouge” of Treg Between IPEX Features and Other Clinical Entities?
Authors: Gentile Micaela , Miano Maurizio , Terranova Paola , Giardino Stefano , Faraci Maura , Pierri Filomena , Drago Enrico , Verzola Daniela , Ghiggeri Gianmarco , Verrina Enrico , Angeletti Andrea , Cafferata Barbara , Grossi Alice , Ceccherini Isabella , Caridi Gianluca , Lugani Francesca , Nescis Lorenzo , Fiaccadori Enrico , Lanino Luca , Fenoglio Daniela , La Porta Edoardo 
Published: April 2022

IntroductionThe Forkhead box protein P3 (FOXP3) is a transcription factor central to the function of regulatory T cells (Treg). Mutations in the FOXP3 gene lead to a systemic disease called immune dysregulation, polyendocrinopathy, and enteropathy, an X-linked syndrome (IPEX) characterized by the triad of early-onset intractable diarrhea, type 1 diabetes, and eczema. An atypical presentation of IPEX has been reported.MethodWe report rare cases with equivocal clinical associations that included inflammatory, kidney, and hematologic involvements screened with massively parallel sequencing techniques.ResultsTwo patients with hemizygous mutations of FOXP3 [c.779T&gt;A (p.L260Q)] and [c.1087A&gt;G (p.I363V)] presented clinical manifestations not included in typical cases of IPEX: one was a 16-year-old male patient with an initial clinical diagnosis of autoimmune lymphoproliferative syndrome (ALPS) and who developed proteinuria and decreased kidney function due to membranous nephropathy, an autoimmune renal condition characterized by glomerular sub-epithelial antibodies. The second patient was a 2-year-old child with bone marrow failure who developed the same glomerular lesions of membranous nephropathy and received a bone marrow transplantation. High levels of IgG4 in serum, bone marrow, and kidney led to the definition of IgG4-related kidney disease (IgG4 RKD) in this young boy. The circulating Treg levels were normal in the former case and very low in the second.ConclusionTwo atypical associations of functional mutations of FOXP3 that include ALPS and IgG4 RKD are described. Membranous nephropathy leading to renal failure completed in both cases the clinical phenotypes that should be included in the clinical panorama of FOXP3 failure.
Impact of COVID-19 Outbreak on the Gynecological Outpatients HPV Infection Rate in Wuhan, China: A Retrospective Observational Study
Authors: Liu Hang , Yao Qian , Li Di , Zhao Zhiming , Li Yan 
Published: April 2022

BackgroundThe recent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) outbreak has caused millions of deaths and greatly influenced the timely diagnosis and treatment of other diseases. Throughout the pandemic, there was a dramatic reduction in the prevalence of several sexually transmitted infections. However, the impact of the ongoing pandemic on human papillomavirus (HPV) infection rates has not been investigated thus far.Materials and MethodsWe retrospectively collected data regarding HPV and cervical cancer screening results of outpatients from gynecological clinics of a tertiary hospital from 1 December 2018 to 31 December 2020 in Wuhan. Based on the timeline of the SARS-CoV-2 pandemic in Wuhan, we divided this period into four relatively independent stages to compare the HPV screening visit numbers and infection rates.ResultsThere was a 50% drop in HPV screening visits and a 10% drop in HPV infection rates throughout the pandemic when compared with the numbers collected before the pandemic. Strict lockdown measures greatly decreased the HPV infection rate (17.03 vs. 8.29, P = 0.003). During the pandemic, the most prevalent HPV genotypes were HPV 16, 52, 58, and 53. After the pandemic, the HPV infection rate recovered quickly, but it was still slightly lower than the infection rate found before the outbreak (23.3 vs. 21.2%).ConclusionDuring coronavirus disease 2019 (COVID-19) pandemic, cervical cancer screening visits and HPV infection rates have decreased dramatically. The HPV transmission has also decreased after strict lockdown. Effective HPV and cervical cancer screening programs should be strengthened immediately to reduce the transmission of HPV during and after the pandemic.
Presbyopia-Correcting Intraocular Lenses Implantation in Eyes After Corneal Refractive Laser Surgery: A Meta-Analysis and Systematic Review
Authors: Sun Yang , Hong Yingying , Rong Xianfang , Ji Yinghong 
Published: April 2022

PurposeTo assess the efficacy, safety, and predictability of presbyopia-correcting intraocular lenses (IOLs) in cataract patients with previous corneal refractive surgery.MethodsA systematic literature search was performed to identify studies evaluating the clinical outcomes of presbyopia-correcting IOLs implantation in cataract surgery after laser refractive surgery. Outcomes were efficacy, safety and predictability parameters.ResultsThe authors identified 13 studies, involving a total of 128 patients and 445 eyes. Presbyopia-correcting IOLs were effective at improving distance, intermediate and near visual acuity aftercataract surgery. The proportion of post-laser surgery eyes with uncorrected distance visual acuity (UDVA) ≥ 20/25 was 0.82 [95% confidence interval (CI), 0.74-0.90] and the pooled rates of spectacle independence at near, intermediate, and far distances were 0.98 (95% CI, 0.94-1.00), 0.99 (95% CI, 0.95-1.00) and 0.78 (95% CI, 0.65-0.94) respectively. The percentage of participants who suffered from halos and glare was 0.40 (95% CI, 0.25-0.64) and 0.31 (95% CI, 0.16-0.60), respectively. The predictability had a percentage of 0.66 (95% CI, 0.57-0.75) and 0.90 (95% CI, 0.85-0.96) of eyes within ±0.5 diopters (D) and ±1.0 D from the targeted spherical equivalent.ConclusionsPresbyopia-correcting IOLs provide satisfactory results in terms of efficacy, safety and predictability in patients with previous corneal refractive surgery, but have a higher risk of photopic side effects such as halos and glare.
Maternal and Neonatal Outcomes After Assisted Reproductive Technology: A Retrospective Cohort Study in China
Authors: Tai Wen , Hu Lingmin , Wen Juan 
Published: April 2022

BackgroundWith the progress of assisted reproductive technology (ART) and the increasing number of ART pregnancy, its safety has become the focus of attention. The present study aimed to explore the associations of ART pregnancy with maternal and neonatal outcomes, as compared with naturally pregnancy.MethodsThis retrospective cohort study included all pregnant women who delivered at Women’s Hospital of Nanjing Medical University in 2011–2020. We compared maternal characteristics and pregnancy outcomes between group of ART pregnancy and group of naturally pregnancy using Logistic regression adjusted for confounders.ResultsA total of 13,604 ART pregnancies and 198,002 naturally pregnancies were included. The proportion of ART pregnancies has increased every year for the past 10 years, peaking in 2020 (9.0%). Multivariable logistic regression analysis showed that the risks of gestational diabetes, preeclampsia, moderate or severe anemia, liver-related diseases, thyroid-related diseases, preterm birth, placenta previa, postpartum hemorrhage, and cesarean section were significantly increased in ART pregnancy. For neonatal outcomes, women conceived by ART were more likely to have twins or multiples, and the risk of stillbirth or abnormal development was also significantly increased. When restriction to singletons, these risks were reduced. And the effects of ART on the risk of premature rupture of membrane, cord entanglement, intrapartum fever, cesarean section, and stillbirth or abnormal development were more pronounced in singletons pregnancies compared with that in pregnancies of twins or multiples.ConclusionWomen conceived by ART were at increased risks of several adverse pregnancy outcomes compared with women conceived naturally. Multiple pregnancies could partly explain this phenomenon. For ART pregnancy, prenatal and intrapartum monitoring should be strengthened, and neonatal outcomes should be closely observed.
Anti-RNP Antibody: A Potential Novel Predictor for Osteonecrosis in Systemic Lupus Erythematosus
Authors: Xiong Jiangbiao , Wang Gang , Xu Tian , Liu Ren , Yu Shujiao , Wang Yan , Wu Rui 
Published: April 2022

ObjectiveTo explore risk factors for developing osteonecrosis in patients with systemic lupus erythematosus (SLE).MethodsTwenty-six SLE patients with osteonecrosis from January 2018 to December 2019 were described. Fifty SLE patients without osteonecrosis were selected as controls from the SLE database (total 2,680) of our hospital during the same period. Clinical manifestations and laboratory tests were recorded and analyzed, especially antibodies. Univariate and multivariate analyses were used to evaluate possible associated risk factors.ResultsTwenty-six (3 male, 23 female) SLE patients with osteonecrosis were confirmed by X-ray and magnetic resonance imaging. The median course from SLE onset to osteonecrosis onset was 45 (range 2–302) months. Seven (27%) patients had a single joint involved and 19 (73%) patients had two or more joints involved. Besides, the incidence of femoral head osteonecrosis (FHON), knee ON, and humerus head ON were 85% (22/26), 27% (7/26), and 12%(3/26), respectively. The multivariate logistic regression analysis showed that the score of European Consensus Lupus Activity Measurement (ECLAM) at SLE onset [odds ratio (OR) 1.37; 95% confidence interval (CI) 1.07–1.75], a cumulative dose of prednisone above 10 g (OR 15.49; 95% CI 3.38–84.61), and positive of independent anti-RNP antibodies (OR 3.35; 95% CI 0.80–10.73) were significantly associated with osteonecrosis in SLE.ConclusionThe score of ECLAM at SLE onset, a cumulative dose of prednisone above 10 g, and positive anti-RNP antibodies are associated with osteonecrosis in SLE. Herein, we reported for the first time that anti-RNP antibodies were associated with osteonecrosis in SLE patients and might be a novel predictor.
Three-Dimensional Analysis of Choroidal Vessels in the Eyes of Patients With Unilateral BRVO
Authors: Chen Lulu , Yuan Mingzhen , Sun Lu , Chen Youxin 
Published: April 2022

PurposeTo investigate the three-dimensional analysis of choroidal vascular changes in eyes with monocular branch retinal vein occlusion (BRVO) using swept-source optical coherence tomography (SS-OCT).MethodsTwenty two unilateral BRVO patients with superior-temporal branch retinal vein occlusion and 27 healthy eyes were analyzed retrospectively. OCT and OCT angiography (OCTA) images of 12 * 12 mm centered on the foveal of each eye were analyzed. Three-dimensional choroidal vascularity index (CVI), choroidal thickness, and choriocapillaris density were compared among BRVO eyes, fellow eyes, and healthy control eyes. En face CVI maps in BRVO eyes were generated to analyze the dilatation pattern of choroidal vessels.ResultsCVI values in a few 1 * 1 mm grids in the non-affected hemi side were higher in BRVO eyes compared with the fellow eyes and control eyes (p&lt; 0.05). Choriocapillaris density decreased in both BRVO eyes and fellow eyes compared with normal eyes while choriocapillaris density was higher in a few grids in the non-affected hemi side in BRVO eyes compared with fellow eyes (p&lt; 0.05). Choroidal dilatation pattern was categorized into four types and inferior choroidal dilatation and posterior pole choroidal dilatation were the major types.ConclusionThree-dimensional CVI tended to increase in non-affected hemi side and choroidal vessels tended to dilate in adjacent areas in BRVO eyes. Choriocapillaris density decreased in both eyes of monocular BRVO patients. The choroidal changes suggested that choroidal redistribution occurred in BRVO.
Bibliometric Analysis of Birt-Hogg-Dubé Syndrome From 2001 to 2021
Authors: Liu Shixu , Xia Kun , Liu Xiaohong , Duan Yuanyuan , Hu Mu , Xia Hongsheng , Lv Jiayu , Zhang Lili , Liu Yanyi , Xia Xiao , Li Guangxi , Cui Xiangning 
Published: April 2022

BackgroundBirt-Hogg-Dubé syndrome (BHD) is a rare autosomal dominant inherited disorder caused by germline mutations in folliculin (FLCN). Despite our significantly evolved understanding of BHD over the past decades, no bibliometric analyses have been conducted in this field. This study aimed to analyze and visualize the characteristics of publication outputs, the research hotspots, and scientific frontiers about BHD using bibliometric analysis.MethodsAll relevant literature on BHD was culled from the Web of Science Core Collection (WoSCC) database. Valid data were extracted from the articles and visually analyzed using CiteSpace and VOSviewer.ResultsA total of 751 qualifying papers were included. Publication outputs concerning BHD increased over time. The dominant position of the United States and Japan in BHD research field was evident. National Cancer Institute (the USA) and Yokohama City University (Japan) were the two most productive organizations. W. Marston Linehan exerted a considerable publication impact and had made the most remarkable contributions in the field of BHD. Plos One was the journal with the highest publication outputs, and half of the top 10 journals and co-cited journals belonged to Q1 or Q2. Keyword citation bursts revealed that management, tumor suppressor, flcn gene, spectrum, diagnosis, risk, computed tomography were the emerging research hotspots.ConclusionResearch on BHD is prosperous. International cooperation between countries and organizations is also expected to deepen and strengthen in the future. Our results indicated that FLCN-associated pathways involved in the pathogenesis of BHD, specific options for early diagnosis, and molecular-targeting therapies will remain research hotspots in the future.