bluuebunny/crossref_metadata_2025_split huggingface dataset:
Redefining GBA gene structure unveils the ability of Cap-independent, IRES-dependent gene regulation
Authors: Miyoshi Keiko , Hagita Hiroko , Horiguchi Taigo , Tanimura Ayako , Noma Takafumi 
Published: July 2022

AbstractGlucosylceramide is the primary molecule of glycosphingolipids, and its metabolic regulation is crucial for life. Defects in the catabolizing enzyme, glucocerebrosidase (GCase), cause a lysosomal storage disorder known as Gaucher disease. However, the genetic regulation of GCase has not been fully understood. Here we show the redefined structure of the GCase coding gene (GBA), and clarify the regulatory mechanisms of its transcription and translation. First, alternative uses of the two GBA gene promoters were identified in fibroblasts and HL60-derived macrophages. Intriguingly, both GBA transcripts and GCase activities were induced in macrophages but not in neutrophils. Second, we observed cap-independent translation occurs via unique internal ribosome entry site activities in first promoter-driven GBA transcripts. Third, the reciprocal expression was observed in GBA and miR22-3p versus GBAP1 transcripts before and after HL60-induced macrophage differentiation. Nevertheless, these findings clearly demonstrate novel cell-type-specific GBA gene expression regulatory mechanisms, providing new insights into GCase biology.
Green synthesis of tungsten oxide (WO3) nanosheets and investigation of their photocatalytic and cytotoxicity effects
Authors: Ghazal Samaneh , Mirzaee Mahdi , Darroudi Majid 
Published: July 2022

AbstractIn the present work, the synthesis of tungsten oxide nanosheets (WO3‐NS) was performed through a sol–gel method with the usage of Na2WO4 as the tungsten source in a gelatin solution that functioned as a novel green stabilising agent. The synthesised WO3‐NS were characterised by the analysing methods of XRD, FESEM/EDX, FTIR, TGA/DTG, UV–vis, Raman, and VSM. The photocatalytic activity of the product is investigated through the exertion of methylene blue pigment, while the obtained results reported 95% of degradation in 187 min under the light of a mercury vapour lamp. The cytotoxicity effect of WO3‐NS on the human liver (Huh‐7) cell line was evaluated by the means of the MTT method, which displayed the inhibiting capabilities of these nanosheets regarding cancer cells.
The city management based on smart information system using digital technologies in China
Authors: Huang Yufang , Peng Hongtao , Sofi Massoud , Zhou Zhiyuan , Xing Tingyan , Ma Guoxing , Zhong Aocheng 
Published: July 2022

AbstractScientific planning, digital management of construction and intelligent service are needed for a smart city. This paper focusses on city management based on the smart information system and digital technologies in China. The establishment of the smart intercommunication system of landscape, water conservancy, environmental protection and other industries is basic for a smart city. This paper introduced a framework of digital technologies for the construction of a smart city, which made full use of the city information modelling based on the geographic information system, building information modelling, internet of things, and integrated digital system and service platform such as satellite remote sensing, global navigation satellite system, mobile applications, cloud computing, visualisation technology etc. The study of the case implemented show that the framework is applicable to the smart city with digital technologies that includes the data model and system, integrating the urban basic geographic data, and data of infrastructure and other public facilities related to traffic, urban construction, ‘One Map’ of land and resources etc. The governance is more effective through data acquisition, data transmission, data analysis and processing based on the data platform and system.
Power transformer oil–paper insulation degradation modelling and prediction method based on functional principal component analysis
Authors: Qu Yuehan , Zhao Hongshan , Zhao Shice , Ma Libo , Mi Zengqiang 
Published: July 2022

AbstractThis study is for the case where the available data of power transformer oil–paper insulation is limited to a small amount furfural data, to solve the problems in oil–paper insulation degradation modelling, such as few samples available, unknown function form of the degradation process, differences of individual transformers among degradation processes, and commonality of degradation trends. A power transformer oil–paper insulation degradation modelling and prediction method based on functional principal component analysis (FPCA) is proposed. First, discrete furfural data of oil–paper insulation degradation are converted into continuous functional data, and the common degradation information of transformers is extracted based on functional time warping technology. Second, the principal components of insulation degradation are extracted based on FPCA method, and the difference of degradation information of individual transformers is obtained by analysing the differential of principal component scores. Subsequently, power transformer oil–paper insulation degradation model is constructed, and finally, the degradation model is updated based on Bayesian theory and the oil–paper insulation degradation is predicted. The example results show that compared with traditional transformer oil–paper insulation degradation modelling method, the proposed method has obvious superiority in model accuracy.
Use of wireless sensor network system based on water level, rain, conductivity, oil and turbidity sensors to monitor the storm sewerage
Authors: Rocher Javier , Rego Albert , Lloret Jaime , Oliveira Luís M. L. 
Published: July 2022

AbstractStorm sewerages are crucial infrastructures in water management. In this paper, a system was developed to detect the blockage of the sewerage and the presence of illegal spills in Storm sewerages. Different nodes with sensors measuring the water level, turbidity, conductivity, and oil presence are scattered in the sewerage. These nodes are connected to a master node for processing the information with a rain sensor. The rain and water level sensors are used to determine one of the four possibilities regarding the presence of water in the sewerage and whether it is raining. According to the combinations, it can be determined whether it is a normal situation or there are spills or blockages. It is shown that there are differences between sewerage with and without blockage via the water level. This can be used to determine the presence of a blockage. The identification of an illegal spill is performed with the use of conductivity, turbidity, and oil sensors. The authors determined that yellow and infrared light can determine the oil concentration in the oil sensor in a range of 0–2.2 mL oil/L water with yellow light and 0.4–20 mL oil/L water with infrared light. Finally, the conductivity sensor can determine water conductivity from 0.526 to 58.4 mS/cm.
The SVOM/ECLAIRs image trigger with wavelet-based background correction optimised with a one-year simulation of observations
Authors: Dagoneau N. , Schanne S. 
Published: July 2022

Context.The Space-based multi-band astronomical Variable Objects Monitor (SVOM) mission under development will carry four instruments, and in particular the coded-mask telescope named ECLAIRs, with a large field of view of about 2 sr, operating in the 4–150 keV energy band. The trigger software on board ECLAIRs will search for high-energy transients such as gamma-ray bursts and peculiar behaviour (e.g. strong outbursts) from known X-ray sources, in order to repoint the satellite to perform follow-up observations with the onboard narrow field of view instruments.Aims.The image trigger, one of the two algorithms implemented in the software on board ECLAIRs, produces images over periods of exposure ranging from 20 s to 20 min during which the Earth can cross the field of view. The Cosmic X-ray Background and contributions from known X-ray sources are expected to dominate the ECLAIRs astrophysical and instrumental background and must be taken into account and corrected prior to coded-mask image deconvolution in order to optimise the sensitivity to faint transients.Methods.To correct these background components, we implemented and studied a traditional fitting method and a new method based on wavelet decomposition of the detector image. In order to study and to assess the performance of these methods, we performed a 1-yr simulation of the image trigger on board ECLAIRs. From the images produced during this realistic observation scenario of the SVOM mission, we also defined a way to analyse the sky images to search for new sources.Results.We present the algorithms behind the image trigger on board SVOM/ECLAIRs. We show that the wavelet method we implemented provides similar results in terms of cleaning performance compared to the traditional fitting method, and has the benefit of not requiring any assumption on the shape of the background on the detector. We also calibrate the detection threshold to be adaptive and based on the quality of the reconstructed sky image.
Tidal excitation of auto-resonant oscillations in stars with close-by planets
Authors: Lanza A. F. 
Published: July 2022

Context. Close-by planets can excite various kinds of oscillations in their host stars through their time-varying tidal potential.
Aims. Magnetostrophic oscillations with a frequency much smaller than the stellar rotation frequency have recently been proposed to account for the spin-orbit commensurability observed in several planet-hosting stars. In principle, they can be resonantly excited in an isolated slender magnetic flux tube by a Fourier component of the time-varying tidal potential with a very low frequency in the reference frame rotating with the host. However, due to the weakness of such high-order tidal components, a mechanism is required to lock the oscillations in phase with the forcing for long time intervals (103–107 yr) in order to allow the oscillation amplitude to grow.
Methods. We propose that the locking mechanism is an auto-resonance produced by the nonlinear dependence of the oscillation frequency on its amplitude. We suggest that the angular momentum loss rate is remarkably reduced in hosts entering auto-resonance and this contributes to maintaining those systems in that regime for a long time.
Results. We apply our model to a sample of ten systems that show spin-orbit commensurability and estimate the maximum drifts of the relevant tidal potential frequencies that allow them to enter the auto-resonant regime. Such drifts are compared with the drifts expected from the tidal evolution of the planetary orbits and the stellar angular momentum loss in the magnetized winds, and we find that auto-resonance is a viable mechanism in eight systems, at least in our idealized model.
Conclusions. The duration of the auto-resonant regime and the associated spin-orbit commensurability may be comparable with the main-sequence lifetimes of the host stars, indicating that gyrochronology may not be applicable to those hosts.
Children with Conductive Hearing Loss Fitted with Hearing Aids: Outcomes and Caregiver Experiences in South Africa
Authors: van Zyl Chéri , le Roux Talita , Swanepoel De Wet 
Published: July 2022

Abstract
Introduction Hearing aids are a frequent management option for children with conductive hearing loss (CHL) and it is necessary to determine the efficacy of outcomes. Limited information regarding caregivers' perceptions and experiences are available to examine outcomes in this population.
Objectives To describe hearing aid outcomes and caregivers' experiences for children with CHL who wear behind-the-ear (BTE) hearing aids.
Methods Retrospective review of clinical data from 19 children between 0 and 13 years of age with CHL, who were fitted with BTE hearing aids between January 2017 and March 2020. Hearing aid outcomes were documented at one month post-hearing aid fitting, via average daily use and caregiver and teacher reports obtained through the Parents' Evaluation of Aural/oral performance of Children (PEACH) and the Teachers' Evaluation of Aural/oral performance of Children (TEACH). Telephonic surveys were conducted with 13 caregivers to explore their experiences. Qualitative data from open-ended questions were analyzed thematically.
Results The average hearing aid use was 6.5 hours/day (2.0 standard deviation, SD; range 4.1–10.3) for bilateral hearing aid users. Questionnaire results indicated that most children (PEACH – 83.3% and TEACH – 92.3%) used their hearing aids more than 75% of the time. Participants performed better in quiet environments with limited sensitivity to loud sounds at home and at school. Reported challenges included stigma and device compliance.
Conclusions Children with CHL used their hearing aids for comparable hours (5–8 hours/day), as reported for children with sensorineural hearing loss, but less than the recommended 10 hours/day required for adequate language development. Caregivers reported benefits equivalent to expectations, with challenges similar to those reported in high-income countries.
MRI Findings in Case of Post–COVID-19 Vaccination Rhabdomyolysis: A Rare Postvaccination Adverse Effect
Authors: Kalekar Tushar M. , Jaipuria Radhika K. , Navani Rahul Srichand 
Published: July 2022

AbstractIn the era of this pandemic, without any proper and efficacious availability of antiviral agents against the novel coronavirus disease 2019 (COVID-19), vaccines have come as a hope for humankind. Although adverse reactions are common after getting the COVID-19 vaccine, serious or life-threatening side effects are very uncommon in these new emergency-approved vaccines. In this case report, we describe an unusual case of adverse reaction in a patient who received the COVID-19 vaccination. The patient who received the COVID-19 vaccination presented with progressive right lower limb pain and swelling, which further progressed to bilateral shoulder pain and swelling. Ultrasonography, Doppler, and magnetic resonance imaging of right lower limb were done for the patient.
Is There Gender (In)Equality in Pediatric Surgery? An Online Survey on Gender-Related Career Opportunities
Authors: Kueppers Julia , Heuer Luisa D. , Szavay Philipp O. , Zundel Sabine 
Published: July 2022

Abstract
Introduction The highest percentage of female surgeons is found in pediatric surgery but most departments are led by men. The aim of this study is to evaluate gender-related career goals, perceived career opportunities, and reasons for differences.
Materials and Methods An online questionnaire was created and distributed to pediatric surgeons in Germany, Switzerland, and Austria between July and September 2020. Participants were asked to state current position, career goals, and perceived career opportunities in comparison to a colleague of the opposite gender. Reasons for gender-related differences were asked for as free-text comments.
Results A total of 182 questionnaires were analyzed. The overall gender ratio was balanced but junior positions were predominantly held by women, while there were more men in leading positions. Most women pursued a position as a consultant, while the majority of men aimed for a leading position. Men mostly regard both genders to have the same career opportunities, whereas most women believe the chances of men to be better. From the free-text answers, three following categories for gender-related differences in career chances were derived: (1) absences due to maternity, (2) differing support and bias arising from gender-related stereotypes, and (3) assumed personality traits.
Conclusion There are gender-related differences in career opportunities in pediatric surgery. Gender equality is needed not only to overcome injustice but also to maximize team efficiency and collaboration. Career support needs to be gender-independent and (unconscious) bias needs to be recognized and eradicated.
Neuroimaging Findings in COVID-19 Associated Rhino-Orbital-Cerebral Mucormycosis: A Review
Authors: Reghunath Anjuna , Ghasi Rohini Gupta , Sharma Anuradha , Bagri Neha , Jain Swarna Gupta 
Published: July 2022

AbstractThe involvement of the neurological system by coronavirus has been well established. Since its onset, the systemic manifestations of coronavirus disease 2019 (COVID-19) have been evolving rapidly and imaging plays a pivotal role in diagnosing the various primary and secondary effects of the disease. As the pandemic continues to defy human civilization, secondary impacts of the disease and the treatment given to patients afflicted with the disease have stemmed up. Rhino-orbital-cerebral mucormycosis is one such potentially dangerous infection now commonly seen in COVID-19 patients, especially the ones treated with immunosuppressants. Early diagnosis is key for COVID-19-associated mucormycosis (CAM), and radiologists should be well aware of its alarming neurological manifestations from the involvement of parenchyma, meninges, vessels, cranial nerves, and skull base. This review highlights the magnetic resonance imaging features of neuraxial involvement in CAM.
Nickel distribution in
Authors: van der Ent Antony , Spiers Kathryn M. , Brueckner Dennis , Erskine Peter D. 
Published: July 2022

Context Hyperaccumulator plants are of considerable interest for their extreme physiology. Stackhousia tryonii is a nickel (Ni) hyperaccumulator plant endemic to ultramafic outcrops in Queensland (Australia) capable of attaining up to 41 300 μg g−1 foliar Ni. Aims This study sought to elucidate the distribution of Ni in S. tryonii by using synchrotron X-ray fluorescence micro-computed tomography (XFM-CT), complemented with elemental maps acquired from physically sectioned plant organs. Its Ni-enriched cylindrical photosynthetic stems make them particularly well suited samples for synchrotron XFM-CT. Methods XFM-CT enables ‘virtual sectioning’ of a sample, avoiding artefacts arising from physical sample preparation. The method can be used on fresh samples that are frozen during the analysis, which preserves ‘life-like’ conditions by limiting radiation damage. It also prevents/minimises other artefacts. Key results The results showed that Ni is mainly concentrated in the apoplastic space surrounding epidermal cells, and in some epidermal cell vacuoles. This finding is significant because this ‘free’ solute Ni is likely to be lost during physical sectioning. Conclusions and implications This case study has highlighted the utility of the XFM-CT approach for visualising metals within intact plant organs, which may be used across the plant sciences.
What role do Australian health professionals play in helping people choose their home care package services?
Authors: Cornell Victoria , Lowies Braam , Lushington Kurt , Helliar Christine 
Published: July 2022

The home care package (HCP) scheme provides funds to eligible older Australians for social, personal and clinical care services, and aims to assist people to age in-home. Uncorroborated evidence suggests older Australians rely on health professionals – especially general practitioners – to prompt HCP assessments, choose service providers and manage HCP funds thereafter. This was confirmed in a survey involving 502 older Australians aged >65 years receiving HCP funds. As more Australians survive to older age, further research is needed to establish with general practitioners their needs regarding the delivery of in-home care information, clinic practice resources, trainee education and continuing professional development.
A Photometric Study of Two Contact Binaries: CRTS J025408.1+265957 and CRTS J012111.1+272933
Authors: Ma Shuo , Liu Jin-Zhong , Zhang Yu , Hu Qingshun , Lü Guo-Liang 
Published: July 2022

Abstract
We performed new photometric observations for two contact binaries (i.e., CRTS J025408.1+265957 and CRTS J012111.1+272933), which were observed by the 1.0 m telescope at Xingjiang Astronomical Observatory. From our light curves and several survey data, we derived several sets of photometric solutions. We found that CRTS J025408.1+265957 and CRTS J012111.1+272933 were A- and W-type W UMa, respectively. The results imply that the spot migrates or disappears in the two contact binaries, which were identified by chromospheric activity emissions (e.g., H
α
emission) from LAMOST spectra. From the O−C curves, the orbital periods of the two contact binaries may be increasing, which is interpreted by the mass transfer from the less massive component to the more massive one. With mass transferring, the two contact binaries may evolve from the contact configurations to semi-detached ones as predicted by the theory of thermal relaxation oscillation.
A systematic evaluation of the computational tools for ligand-receptor-based cell–cell interaction inference
Authors: Wang Saidi , Zheng Hansi , Choi James S , Lee Jae K , Li Xiaoman , Hu Haiyan 
Published: July 2022

AbstractCell–cell interactions (CCIs) are essential for multicellular organisms to coordinate biological processes and functions. One classical type of CCI interaction is between secreted ligands and cell surface receptors, i.e. ligand-receptor (LR) interactions. With the recent development of single-cell technologies, a large amount of single-cell ribonucleic acid (RNA) sequencing (scRNA-Seq) data has become widely available. This data availability motivated the single-cell-resolution study of CCIs, particularly LR-based CCIs. Dozens of computational methods and tools have been developed to predict CCIs by identifying LR-based CCIs. Many of these tools have been theoretically reviewed. However, there is little study on current LR-based CCI prediction tools regarding their performance and running results on public scRNA-Seq datasets. In this work, to fill this gap, we tested and compared nine of the most recent computational tools for LR-based CCI prediction. We used 15 well-studied scRNA-Seq samples that correspond to approximately 100K single cells under different experimental conditions for testing and comparison. Besides briefing the methodology used in these nine tools, we summarized the similarities and differences of these tools in terms of both LR prediction and CCI inference between cell types. We provided insight into using these tools to make meaningful discoveries in understanding cell communications.