bluuebunny/crossref_metadata_2025_split huggingface dataset:
Factors associated with awareness and passage of medical screening in hypertensive persons: data from the Know Your Heart study
Authors: Kashutina M. I. , Kontsevaya A. V. , Kudryavtsev A. V. , Malyutina S. K. , Ipatov P. V. , Drapkina O. M. 
Published: March 2022

Aim. To analyze the demographic, socio-economic and behavioral factors associated with awareness and passage of medical screening among the hypertension adults from Arkhangelsk and Novosibirsk.Material and methods. The database was formed as part of the Know Your Heart study (2015-2018, Arkhangelsk, Novosibirsk, n=4504). For the present study, 2216 people with hypertension were selected. Binary logistic regression was used to determine the factors associated with awareness of ongoing medical screening and active participation in them.Results. The analysis determined that 82,5% of the hypertensive residents of Arkhangelsk and Novosibirsk aged 35-69 years old are aware of the medical screening, and 51,4% have passed (are going to pass) it. General factors associated both with greater awareness of ongoing preventive measures and with greater participation in them are female sex and contacts with doctors during the year. From the point of view of awareness, such a factor as the average income level turned out to be significant, while the absence of a permanent employment and the pension status were associated with the passage of medical screening.Conclusion. The awareness of the hypertensive residents of Arkhangelsk and Novosibirsk about the medical screening was 82,5%. The coverage level is still low. The identified factors associated with greater awareness of the medical screening and more active participation showed that medical specialists should be more attentive to the men working in urban areas with a low income level. More active work is also needed to involve in preventive contacts those persons who are not in constant contact with the healthcare system. This requires the consolidated work of various institutions and departments, including the media.
Levels of angiogenesis markers in patients with different heart failure phenotypes
Authors: Shepel R. N. , Drapkina O. M. 
Published: March 2022

Aim. To assess the relationship between the levels of angiogenesis markers and various heart failure (HF) phenotypes in patients with class II-IV HF of ischemic origin.Material and methods. This cross-sectional cohort study was based on the clinical departments of the National Medical Research Center for Therapy and Preventive Medicine. The study involved 180 patients aged 30-85 years with class II-IV HF of ischemic origin as follows with (n=90) and without (n=90) metabolic syndrome (MS). All patients included in the study signed an informed consent to personal data processing, participation in a clinical trial and consent to blood biobanking. All patients were divided into three groups: HF with reduced ejection fraction (HFrEF) — left ventricular (LV) EF <40%, HF with mildly reduced EF (HFmrEF) — LVEF from 40 to 49%, HF with preserved EF (HFpEF) — LVEF >49%. In addition to the standard paraclinical investigations, angiogenesis markers were analyzed with the determination of transforming growth factor β (TGF-β), vascular endothelial growth factor A (VEGF-A), pentraxin-3 (PTX-3). Statistical analysis was performed using Microsoft Office Excel, STATISTICA 10.0 software packages (Statsoft, USA).Results. Transthoracic echocardiography determined that 74 (41,1%) patients had LVEF <50%, while 71 (39,4%) — <40%. For the group of patients with HFpEF, there was an association with an increase in TGF-β ≥7,2 ng/ml (p=0,011). The threshold level of PTX-3 ≥55 ng/ml is associated with the development of HFpEF (p=0,001). For the HFmrEF phenotype, the threshold values of VEGF-A, TGF-β and PTX-3 were determined, which did not reach the significance level. However, an upward trend in VEGF-A >200 ng/ml was noted (p=0,052). In HFrEF patients, a threshold value of VEGF-A >195 ng/ml (p=0,001) associated with reduced LVEF was determined.Conclusion. Thus, the present work showed the relevance of using PTX-3, VEGF-A and TGF-β as additional markers for assessing the HF course. So, patients with HFpEF had increased levels of PTX-3 and TGF-β, while patients with HFmrEF and HFrEF — increased VEGF-A values. Determination of the level of these angiogenesis markers should be used to improve the efficiency of diagnosis and treatment of patients with various class II-IV HF phenotypes.
EFEKTIVITAS PERMAINAN BIG MAZE TERHADAP KEMAMPUAN ANAK MENGENAL ANGKA USIA 5-6 TAHUN DI TAMAN KANAK-KANAK AN-NUR
Authors: Ramadhani Cici , Zulminiati Zulminiati 
Published: March 2022

Abstrak: Penelitian ini bertujuan untuk dapat memperoleh gambaran menegnai bagaimana efektivitas mengenal angka 1-10 melalui permainan Big Maze pada anak usia 5-6 tahun di TK An-Nur. Penelitian ini menggunakan metode eksperimen ( quasi experimen) . sampel pada penelitian ini adalah kelompo B1 kelas eksperimen menggunakan permainan Big Maze untuk mengenal angka 1-10 dan kelompok B2 Kelas kontrol menggunkan permainan uar tangga angka untuk mengenalkan angka 1-10. Adapun teknik yang digunakan dalam pengumpulan data penelitian ini adalah tes yang digunakan untuk melihat pengaruh penggunaan Big Maze terhadap mengenal angka anak di Taman Kanak-kanak An-Nur. Hasil penelitian mnunjukkan bahwa hasil belajar di kelas eksperimen memiliki nilai rata-rata sebesar 85,625 dan rata-rata kelas kontrol 75,625. Yang berarti bahwa ada terjadinya peningkatan di kelas eksperimen ketika menggunkan permainan Big Maze , maka penggunaan permainan Big Maze efektif digunakan pada kemampuan mengenal angka 1-10 usia 5-6 tahun di taman kanak-kanak annur.
Imaging the Upper 10 km Crustal Shear-Wave Velocity Structure of Central Myanmar via a Joint Inversion of P-Wave Polarizations and Receiver Functions
Authors: Yao Jiayuan , Wu Shucheng , Li Tianjue , Bai Yiming , Xiao Xiao , Hubbard Judith , Wang Yu , Thant Myo , Tong Ping 
Published: March 2022

Abstract
Myanmar occupies a complex region in the active Indo-Burma subduction system. To illuminate the upper 10 km crustal structure of central Myanmar and obtain new insight into the subduction system, we jointly use P-wave polarizations and receiver functions (RFs) to construct a high-resolution VS profile based on a Bayesian Markov chain Monte Carlo approach. This obtained profile clearly delineates six tectonic units and their boundaries, including the Indo-Burman ranges (IBR), the IBR-fore-arc basin boundary, the fore-arc basin, the volcanic arc, the back-arc basin, and the Sunda plate. The Sunda plate has relatively higher upper crustal VS (&gt;3.0 km/s) and thinner sedimentary cover (∼1 km) compared with the Central Myanmar basin in the Burma plate. The fore-arc basin, containing thick sediments (&gt;10 km), and the back-arc basin, with thinner sediments (∼1–6 km), are separated by a region with higher VS (∼3.0 km/s), which represents crystallized magma beneath the volcanic arc. A narrow zone of relatively high-VS (∼2.6–2.7 km/s) ophiolites is situated between the fore-arc basin and the IBR. We also find a narrow zone of high-VS (∼2.9 km/s) metamorphic rocks contained within the low-VS (≲2.3 km/s) IBR. This study suggests that the proposing joint inversion of two types of single-station measurements, that is, P-wave polarizations and RFs, can robustly and computationally efficiently image the shallow VS structure and provide a reliable uncertainty estimation.
Pomiędzy światem „czynnego alkoholizmu” a rzeczywistością zdrowienia. Mechanizmy (re)socjalizacyjne anonimowych alkoholików
Authors: Trzebiatowski Jakub 
Published: March 2022

Celem artykułu jest przedstawienie specyfiki mechanizmów (re)socjalizacji anonimowych alkoholików w perspektywie zamiany subświata „czynnego alkoholizmu” na rzeczywistość zdrowienia.
Prezentowane w opracowaniu konkluzje i wnioski formułowałem w oparciu o badania jakościowe, które zyskały charakter monograficzno-biograficzny. Wykorzystałem procedurę badań terenowych oraz procedurę badań sondażowych pogłębionych. Przyjąłem ponadto kryteria metodologii teorii ugruntowanej. Próba badawcza liczyła 18 zdrowiejących alkoholików poznańskich grup AA.
W wyniku przeprowadzonych badań empirycznych wyselekcjonowałem cztery mechanizmy (re)socjalizacji: afiliacyjno-afektywny, komunikacyjno-poznawczy, katharsis – budowania nowej tożsamości oraz podtrzymywania nawrócenia. Za sprawą wspomnianych mechanizmów aktorzy społeczni zyskiwali szansę na alternację – subświat terapeutyczny AA stopniowo stawał się „rzeczywistością podstawową” – „światem życia codziennego” zdrowiejących alkoholików.
Effect of Anodal Transcranial Direct Current Stimulation to Flexor Digitorum Superficialis Muscle Activities in Stroke Subjects
Authors: Mursyida Ana , Masduchi Reni Hendrarati , Subadi Imam 
Published: March 2022

Background: Stroke is the main causes of upper extremity weakness that may affect physicalindependency resulting in long-term disability. Previous studies showed that A-tDCS can improve neurological damage. A-tDCS causes depolarization and inducesbrainsynapticplasticity in strokesubjects.Aim: To analyze the effect of Anodal-tDCS to the flexor digitorum superficialis muscles activities in stroke subjects.Material and Methods: This experimental study was conducted from April to September 2020. Eightpatients who suffered first attack ischemic stroke, aged 40 to 70 years old, were recruited from PMR out patient clinic at Dr.Soetomo General Hospital Surabaya. Subjects were randomized in to experimental and control group. The control group was given occupational therapy for 30 minutes, while the experimental group was given A-tDCS with intensity 2 mA for 20 minutes and occupational therapy for 30 minutes in 5 consecutive days. Measurement of FDS muscle activities using sEMG were performed before and after interventionin both groups. Results: There was an increase of FDS muscles activities after treatment incontrol group (p=0,048) while there was no similar result in treatment group (p=0,188). Thechangeofmuscles activities was notdifferent betweengroups(p=0,974).Conclusion: tDCS provides no significant benefit in terms of muscle activities in patients with stroke. Small number of samples and other several factors might limit the significancy of current study. Further study is needed to determine the benefit of A-tDCS as a rehabilitation modality in patient with stroke.
The Relationship Between Histopathological Grading and Metastasis in Colorectal Carcinoma Patients
Authors: Minhajat Rahmawati , Benyamin Andi Fachruddin , Miskad Upik Andariana 
Published: March 2022

Introduction: To Colorectal cancer (CRC) is a malignancy in the large intestine caused by uncontrolled cell growth. The cause of death due to metastasis and the prognosis is determined by the stage that can be assessed using Dukes classification or TNM (Tumor Nodes Metastasis) staging system. Determination of histopathological grading is important because of the differences in radiosensitivity, local behaviour and the metastasis tendency. The aim of this study is to determine the relationship between histopathological grading and metastasis in colorectal cancer patients. Methods: This study is a cross-sectional study using secondary data from the medical records of CRC patients at the RS. Dr. Wahidin Sudirohusodo and its networking hospital, that were obtained by consecutive sampling. Inclusion criteria are all patients who had surgery and have the results of histopathology, radiology and other datas that may be used as a reference for determining the staging based on the Dukes classification and TNM staging system Results: The number of CRC patients during January 2008 to April 2012 was 268 patients, 55,6% of them were males and mostly their age were around 51-60 years old (25,4%). Most of the CRC location was in the rectum (61,2%) and the highest number of metastasis location was in lymph nodes (40,4%). Out of 179 patients who had result of histopathological examination, adenocarcinoma type (100%) and moderately differentiated adenocarcinoma (45,3%) were the most frequently histopathological grading found. Most of the CRC stage based on the TNM staging system was stage IV (27,4%) and based on the Dukes classification was stage D (26,8%). There is a significant relationship (p<0,001) between histopathological grading and metastasis, and it showed that poorly differentiated adenocarcinoma was more frequent in advanced stage, based on both the Dukes classification and TNM staging system. Conclusions: There is a significant relationship between histophological grading and metastasis. Poorly differentiated adenocarcinoma is more likely to be found in advanced stage of CRC.
Pelatihan Kader Posyandu Dan Posbindu Untuk Meningkatkan Performa Kader Di Wilayah Puskesmas Gondangrejo Kabupaten Karanganyar
Authors: Marufah Siti , Listyaningsih Endang , Handayani Selfi , Balgis Balgis , Riyadi Slamet , Setyoko Arif 
Published: March 2022

<p><strong>Pendahuluan:</strong> Kader yang merupakan tangan panjang dari Puskesmas memiliki peranan yang penting dalam bidang kesehatan, karena memiliki fungsi strategis dalam menangani masalah kesehatan perseorangan maupun masyarakat. Setiap bulan kader melaksanakan kegiatan layanan pemeriksaan di posyandu lansia dan balita serta posbindu dengan supervisi bidan pembina wilayah serta dibawah tanggungjawab Puskesmas. Puskesmas Gondangrejo terdapat di Kabupaten karanganyar yang memiliki 93 buah posyandu dengan 240 kadernya yang tersebar di seluruh wilayah kecamatan. Hampir 100% kader merangkap sebagai kader posyandu lansia maupun balita serta posbindu. Oleh karena itu kemampuan dan ketrampilan kader perlu selalu ditingkatkan melalui pelatihan untuk meningkatkan kualitas layanan kesehatan. Pengabdian ini bertujuan untuk memberikan pelatihan kader posyandu dan posbindu di wilayah Puskesmas Gondangrejo Karanganyar.</p><p><strong>Metode :</strong> Pengabdian dilakukan dengan memberikan pelatihan kader tentang antropometri kepada kader baik untuk dewasa, lansia dan bayi (materi dan praktik), pelatihan juga diisi motivasi sebagai kader kesehatan melalui kegiatan <em>ice breaking</em> dilanjutkan dengan analisis hasil secara diskriptif, selain itu dilakukan evaluasi keberhasilan program pengabdian. Pengabdian dilaksanakan di Puskesmas Gondangrejo pada bulan februari 2020 dengan subyek kader kesehatan.</p><p><strong>Hasil dan Pembahasan : </strong>Pengabdian dilaksanakan dengan baik dan mendapat dukungan penuh oleh kepala puskesmas. Puskesmas mendapatkan manfaat dengan meningkatnya pengetahuan dan ketrampilan kader, sehingga meningkatkan performa dari kader. Pengabdian ini juga memberikan sumbangsih besar dalam peningkatan motivasi kader. Antusiasme kader kesehatan terlihat dari disiplinnya kader yang mengikuti program juga keaktifan dalam diskusi. Pemahaman materi mengalami peningkatan dilihat dari nilai rata-rata nilai postest yang meningkat 27%. Motivasi kader meningkat menjadi 100% dengan peningkatan ketrampilan sebesar 98% dan kader merasakan kebermanfaatan sebanyak 100% dari pengabdian ini.<strong></strong></p><p><strong>Kesimpulan :</strong>Pengabdian ini memberikan sumbangsih bagi peningkatan performa kader posyandu dan posbindu di wilayah puskesmas gondangrejo Karanganyar.</p><p><strong> </strong></p><p><strong>Kata kunci: Pelatihan; Kader; Performa; Puskesmas.</strong></p>
Leadership Principles in Uncertain Times. Presidential Address to the AOA, June 10, 2021
Authors: Hu Serena S. 
Published: March 2022

Abstract:
One of the core foundations of leadership is communication. This past pandemic year gave us lessons in how to improve communication during uncertain times as well as examples of strong leadership in the public sphere. The AOA has formulated important Leadership Principles to guide future educational offerings. I will discuss the importance of these Leadership Principles and give examples of how we can apply these principles.
Comparison of outcomes of trans-subclavian versus trans-apical approaches in transcatheter aortic valve implantation
Authors: Tomala Olaf , Zamvar Vipin , Bing Rong , Pessotto Renzo , Cruden Nick 
Published: March 2022

Abstract
Background
Many patients are unsuitable for conventional femoral transcatheter aortic valve implantation (TAVI) but there is limited evidence as to which alternative approach has the best outcomes. We compared clinical outcomes in patients undergoing trans-subclavian (TS) or trans-apical (TA) TAVI.
Methods
This was a national retrospective observational study of patients undergoing surgical TAVI in Scotland between January 2013 and March 2020. The pre-operative patient characteristics, intraoperative details and post-operative outcomes were compared between TS and TA cohorts using data from the National Institute of Cardiovascular Outcomes Research (NICOR) registry.
Results
Among 1055 patients who underwent TAVI, TS or TA access was used in 50 (4.7%) and 90 (8.5%) patients respectively. Self-expanding Medtronic Evolut R valves were used in 84% of TS procedures, while balloon-expandable Edwards SAPIEN valves were used in all TA procedures. The TS group had a lower mean logistic EuroSCORE than the TA group (27.31 ± 19.44% vs 34.92 ± 19.61% p = 0.029). The TS approach was associated with a higher incidence of moderate postprocedural aortic regurgitation (12.5% vs 2.4%, p = 0.025). There was no significant difference in 30-day, 1-year or overall all-cause mortality.
Conclusions
Both trans-subclavian and trans-apical access are viable approaches for patients requiring non-transfemoral TAVI. Differences in peri-procedural indices reflect the disparate patient populations and factors governing prosthesis choice, and short- and long-term mortality was similar.
Presepsin and platelet to lymphocyte ratio predict the progression of septic subclinical acute kidney injury to septic acute kidney injury and the prognosis of subclinical septic acute kidney injury patients: a pilot study
Authors: Shimoyama Yuichiro , Umegaki Osamu , Kadono Noriko , Minami Toshiaki 
Published: March 2022

Abstract
Objective: This study aimed to determine whether presepsin can predict the progression of septic subclinical acute kidney injury (AKI) to septic AKI among intensive care unit (ICU) patients.Results: Presepsin values were measured immediately after ICU admission (baseline) and on Days 2, 3, and 5 after ICU admission. Glasgow Prognostic Score, neutrophil to lymphocyte ratio, platelet to lymphocyte ratio (PLR), Prognostic Index, and Prognostic Nutritional Index were measured at baseline. Presepsin values and these indices were compared between septic AKI and septic subclinical AKI patients. There were 38 septic AKI patients and 21 septic subclinical AKI patients. Receiver operating characteristic curve analyses revealed the following cut-off values for AKI (relative to subclinical AKI): 708.0 (pg/ml) for presepsin on Day 1 (AUC, 0.69; sensitivity, 82%; specificity, 52%), 1283.0 (pg/ml) for presepsin on Day 2 (AUC, 0.69; sensitivity, 55%; specificity, 80%), and 368.66 for PLR (AUC, 0.67; sensitivity, 71%; specificity, 62%). Multivariate logistic regression analyses revealed PLR to be a predictor of septic subclinical AKI (odds ratio, 1.0023; 95% confidence interval, 1.0000-1.0046; p=0.046). Presepsin and PLR predicted the progression of septic subclinical AKI to septic AKI and the prognosis of subclinical septic AKI patients.
Exploratory study on interaction between bacteria and fungi from mulberry to intestine of Bombyx mori
Authors: Li Chengxu , Xu Shuo , Xiang Chunjie , Xu Shixia , Zhou Qihai , zhang junfeng 
Published: March 2022

Abstract
Many kinds of antibiotics in the environments deeply affect the microbial composition, but their effect on the interactions among the host microbiota is still poorly understood. This study used Bombyx mori as the model organism by feeding the antibiotics-treated mulberry leaf, preliminarily explored the effects of antibiotic exposure on the interaction of bacteria and fungi in the worm’s intestine. Our results showed that the elimination of fungi significantly reduced the bacterial richness and diversity in the worm’s intestine after exposure of anti-fungal amphotericin B, while the elimination of bacteria dramatically increased the richness and diversity of fungi after exposure of anti-bacterial ampicillin-streptomycin. The results revealed the intestinal bacteria and fungi of Bombyx mori were markedly shaped by the mulberry leaf flora. Anti-bacterial antibiotics enhanced the correlation between the host gut fungi and the diet-deriving fungi, while anti-fungal antibiotics weakened the correlation between the host gut bacteria and the diet-deriving bacteria. The data preliminarily established a simple model to explore the effect of antibiotics on the host microbiota interactions, and provided a way for further study on the environmental factors of intestinal bacteria-fungi interaction.
Appropriateness and adherence to guidelines in perioperative antimicrobial prophylaxis in patients undergoing clean surgery: results from a Quality Control Circle intervention
Authors: Zou Jian , Zhong Jia-yun , Liu Yu , Huang Dan , Liu Yan-xin , Li Xi-wen , Gong Wen-jun , Tao Jia 
Published: March 2022

Abstract
The present study aimed to exam the effect of quality control circle (QCC) activities on promoting the appropriate implementation of preoperative antibiotic prophylaxis in clean surgery. A QCC activity team was established to grasp the current situation of PAP in clean surgery procedure, set target, formulated corresponding countermeasures and implement and review them in stages. The plan-do-check-act method was cyclically applied. The appropriateness of PAP before (July to December 2018) and after (April to September 2019) the implementation of QCC activities were evaluated based on relevant international and Chinese perioperative antimicrobial prophylaxis guidelines. The appropriate rate of PAP was significantly improved from 68.72% (n=406) before QCC to 93.7% (n=508) post QCC implementation (P＜0.01). A significant improvement (P＜0.05) was also determined for each category: selection (from 78.82 to 96.06%), duration (from 90.15 to 96.46%), indication (from 94.09 to 97.64%), timing of first dose (from 96.55 to 99.21%), antibiotic usage (from 96.8 to 99.41%), re-dosing of antibiotic (from 96.55 to 99.21%). The appropriate application of PAP is improved through QCC activities, providing a useful reference for the prevention of antimicrobial-resistant bacteria and the development of medical quality improvement activities.