bluuebunny/crossref_metadata_2025_split huggingface dataset:
The efficiency and safety of Shengxuening tablet on treating and preventing iron deficiency anemia: A systematic review and meta-analysis
Authors: Zhang Yanyu , Lv Yan , Sun Yan , Li Yumeng , Wang Dehao , Niu Jicong , Zhao Pei , Zhang Mei , Wang Mingjing , Liu Weiyi , Hu Xiaomei 
Published: November 2022

Background: Iron deficiency anemia (IDA) is a public health problem worldwide. Shengxuening Tablet (SXN) has been used for the treatment of various types of anemia, attaining high efficacy.Objective: To evaluate the safety of SXN as well as its preventive and therapeutic efficacy against IDA across different population groups.Methods: PubMed, Embase, Web of Science, the Cochrane Library, the China Knowledge Network, the China Biomedical Literature Database, the Wanfang Data Knowledge Service Platform, and the China Science and Technology Journal Database was searched for relevant clinical trials through June 2022 and a systematic review and meta-analysis of the identified studies was undertaken.Results: A total of 39 trials involving 4,562 cases were included in the meta-analysis. The total efficiency of SXN was superior than the control group in improving red blood cell (RBC) count [SMD = 1.31, 95% CI (0.7, 1.91), p &lt; 0.0001], hemoglobin (Hb) [SMD = 1.11, 95% CI (0.75, 1.46), p &lt; 0.00001], mean corpuscular volume (MCV) [SMD = 0.5, 95% CI (0.33, 0.68), p &lt; 0.00001], total serum iron (SI) levels [SMD = 1.87, 95% CI (1.3, 2.44), p &lt; 0.00001], and transferrin saturation (TSAT) levels [SMD = 2.07, 95% CI (1.86, 2.27), p &lt; 0.00001]. Besides, the total effects of SXN to improve mean corpuscular hemoglobin (MCH) [SMD = 0.12, 95% CI (−0.16, 0.4), p = 0.41], mean corpuscular hemoglobin concentration (MCHC) [SMD = 0.03, 95% CI (−0.18, 0.24), p = 0.77], hematocrit (HCT) [SMD = 0.65, 95% CI (−0.25, 1.55), p = 0.16], and serum ferritin (SF) levels [SMD = 0.59, 95% CI (−0.67, 1.85), p = 0.36] and reduce the total iron binding capacity (TIBC) [SMD = 0.34, 95% CI (−0.07, 0.74), p = 0.1] was comparable to that of iron supplementation. SXN significantly raised the total effective rates of IDA [risk ratio (RR) = 1.06, 95% CI (1.02, 1.09), p = 0.0005] and was associated with fewer adverse events [RR = 0.24, 95% CI (0.18, 0.31), p &lt; 0.00001], fewer adverse pregnancy outcomes [RR = 0.34, 95% CI (0.2, 0.57), p &lt; 0.0001], and lower anemia recurrence rates during pregnancy [RR = 0.29, 95% CI (0.1, 0.84), p = 0.02]. Regarding prevention, the effects of SXN to maintain the RBC count, Hb level and other IDA-related parameters were comparable to that of control group and SXN reduced the risk of IDA incidence during pregnancy.Conclusion: SXN demonstrated promising efficacy in the treatment and prevention of IDA and outperformed routine iron formulations in terms of safety, thus rendering SXN a reliable treatment option for IDA.Systematic Review Registration:https://www.crd.york.ac.uk/prospero/, identifier: CRD42022353247.
Efficacy and safety of midazolam combined with dezocine for sedation and analgesia in digestive endoscopy: A prospective open single-center study
Authors: Chen Yongpeng , Sun Jiachen , Lu Yi , Fu Liping , Xiang Xueyuan , Liu Yanan , Zhuo Xianhua , Kurban Mirigul , Li Chujun 
Published: November 2022

Objective: Digestive endoscopy is an important means of diagnosing and treating gastrointestinal diseases and a tool for screening and monitoring early gastrointestinal tumors. Digestive endoscopy can be performed using midazolam combined with dezocine for sedation and analgesia. This study explored the efficacy and safety of midazolam combined with dezocine.Methods: A total of 135 patients undergoing digestive endoscopy in the Department of Gastrointestinal Endoscopy of the Sixth Affiliated Hospital, Sun Yat-sen University, from June 2021 to September 2021, were enrolled and non-blindly and non-randomly divided into a sedation-endoscopy-group (SEG, n = 45), anesthesia-endoscopy-group (AEG, n = 44), and ordinary-endoscopy-group (OEG, n = 46). Vital signs, levels of sedation and analgesia, the degree of pain during colonoscopy, satisfaction, and the incidence of complications were compared among the three groups.Results: There were no statistically significant differences in vital signs (blood pressure, pulse, respiration, and blood oxygen saturation) among the three groups before endoscopy (p &gt; 0.05). The AEG reported no pain during colonoscopy, and the pain score during colonoscopy for the SEG was lower than that for the OEG (1.11 ± 1.21 vs. 3.00 ± 1.16, p &lt; 0.001). The scores for satisfaction were 8.84 ± 1.30 points in the SEG, 8.95 ± 1.10 points in the AEG, and 6.37 ± 0.90 points in the OEG; the differences were statistically significant (p &lt; 0.001). The total incidence of complications in the AEG was 38.64% (17/44), which was significantly higher than that in the SEG [13.33% (6/45)] and OEG [13.04% (6/46)] (p &lt; 0.001). In the SEG, the overall incidence of complications in women was significantly higher than that in men (p = 0.027).Conclusion: Digestive endoscopy using midazolam combined with dezocine for sedation makes patients more comfortable, more satisfied and more compliant than the ordinary endoscopy. Additionally, it is comparable to endoscopy under general anesthesia with propofol with regard to comfort, satisfaction, and patient compliance and comparable to the ordinary endoscopy with regard to safety. Considering the shortage of anesthesiologists, the application of midazolam combined with dezocine in digestive endoscopy is worthy of clinical popularization. This study has been registered in the Hospital Ethics Committee of the Sun Yat-sen University Sixth Affiliated Hospital (Ethical Number: 2021ZSLYEC-182).
Functional study of CYP90A1 and ALDH3F1 gene obtained by transcriptome sequencing analysis of Brassica napus seedlings treated with brassinolide
Authors: Gan Qingqin , Luan Mingbao , Hu Maolong , Liu Zhongsong , Zhang Zhenqian 
Published: November 2022

Sclerotinia disease and weeds of Brassica napus greatly reduce crop yields. However, brassinolides can improve the resistance of plants to sclerotinia diseases and herbicides. In this study, we investigated the effects of brassinolide on the occurrence, physiological indices, yield, and gene expression of Fanming No. 1 seeds under sclerotinia and glufosinate stress. The results showed that soaking of the seeds in 0.015% brassinolide for 6 h reduced the incidence of sclerotinia by 10%. Additionally, in response to glufosinate stress at the seedling stage, the enzyme activities of catalase and superoxide dismutase increased by 9.6 and 19.0 U/gFW/min, respectively, and the soluble sugar content increased by 9.4 mg/g, increasing the stress resistance of plants and yield by 2.4%. LHCB1, fabF, psbW, CYP90A1, ALDH3F1, ACOX1, petF, and ACSL were screened by transcriptome analysis. ALDH3F1 and CYP90A1 were identified as key genes. Following glufosinate treatment, transgenic plants overexpressing ALDH3F1 and CYP90A1 were found to be resistant to glufosinate, and the expression levels of the ALDH3F1 and CYP90A1 were 1.03–2.37-fold as high as those in the control. The expression level of ATG3, which is an antibacterial gene related to sclerotinia disease, in transgenic plants was 2.40–2.37-fold as high as that in the control. Our results indicate that these two key genes promote plant resistance to sclerotinia and glufosinate. Our study provides a foundation for further studies on the molecular mechanisms of rapeseed resistance breeding and selection of new resistant varieties.
TikTok and YouTube as sources of information on anal fissure: A comparative analysis
Authors: Chen Zeyang , Pan Shaorong , Zuo Shuai 
Published: November 2022

IntroductionAnal fissure is a common colorectal disease impacting patients' life quality with high incidence. Social media platforms are becoming a kind of health information source nowadays. This study aims to evaluate and compare the quality of anal fissure-related videos on TikTok and YouTube.Materials and methodsOne hundred videos were sourced from TikTok and YouTube, respectively and videos were screened further. The completeness of six types of content within the videos is assessed, including the definition of disease, symptoms, risk factors, evaluation, management and outcomes. Finally, the DISCERN instrument, Patient Education Materials Assessment Tool and Global Quality scale are used to assess video display quality and content. A correlation analysis is undertaken considering the video features, DISCERN, PEMAT and GQS scores.ResultsPhysicians and non-profit organizations contributed almost all video content among selected videos. A statistically significant correlation between DISCERN classification and duration, PEMAT understandability, PEMAT actionability and GQS scores is recorded. DISCERN total scores were significantly positively correlated with video duration, PEMAT understandability, PEMAT actionability and GQS scores. GQS scores were significantly positively correlated with duration, PEMAT understandability and PEMAT actionability scores. For content, the videos mainly described management and symptoms while containing limited information on the disease evaluation, and outcomes.ConclusionsThe sources of uploaders on YouTube are more diverse than TikTok, and the quality of videos is also relatively higher on YouTube. Even so, the video quality of the two platforms still needs to be further improved. Health information without integrity, reliability and practicability impacts patients' disease perception and health-seeking behavior, leading to serious consequences. Much effort must be taken to improve the quality of videos regarding anal fissures on the two platforms, which will facilitate the development of public health education on this issue.
Evaluating new simplified assays for harm reduction from methanol poisoning using chromotropic acid kits: An analytical study on Indian and Iranian alcoholic beverages
Authors: Rafizadeh Ali , Bhalla Ashish , Sharma Neha , Kumar Kuldeep , Zamani Nasim , McDonald Rebecca , Roberts Darren M. , Hassanian-Moghaddam Hossein 
Published: November 2022

BackgroundIngestion of methanol can result in severe irreversible morbidity, and death. Simple and easy methods to detect methanol and other hazardous additives prior to consumption can prevent fatalities. This form of harm reduction is analogous to the widely practiced “pill testing” of recreational drugs in various countries. We aimed to evaluate the performance of two qualitative and quantitative kits to simultaneously identify the presence of methanol and formaldehyde in alcoholic beverages, and compare this to the standard gas chromatographic (GC) method.MethodsTwo-hundred samples of Indian and Iranian alcoholic drinks were examined by two new qualitative and quantitative chemical kits designed based on a modified chromotropic acid (CA) method, as well as a gold standard GC method.ResultsMethanol levels were similar when evaluated by GC and quantitative method (Z = – 0.328, p = 0.743). The 75th percentile of methanol level detection was 4,290 mg L−1 (range; 0–83,132) using GC compared to that of 4,671 mg L−1 (range; 0–84,960) using the qualitative kit (predefined color intensity reflecting the methanol/ethanol ratio). The quantitative kit was able to detect all methanol-contaminated and non-contaminated samples (110 and 60 cases, respectively: 100% sensitivity). In 25 samples, GC analysis showed no methanol; but the qualitative kit detected possible toxic substances. Formaldehyde measurement by UV/Vis analysis showed the presence of formaldehyde in 23 samples (92%) with a median 912 [IQR 249, 2,109; range 112–2,742] mg L−1.ConclusionMethanol and formaldehyde can be easily detected using these simple CA chemical kits. Qualitative positive results may indicate the risk of poisoning if the beverage is consumed. CA kits can be used in community setting by public health units and community organizations to monitor for methanol contamination and inform a public health response to reduce methanol-related harms to the public.
L’aménagement du val de Maine
Authors: Jeanneau Jacques 
Published: November 2022

La vallée de la Maine, sans doute guidée par des failles, est un chapelet de petites plaines alluviales submersibles , bordées par deux niveaux discontinus de terrasses et dominées par des coteaux appalachiens.
Jadis, la Maine à Angers se divisait en plusieurs bras, et il n'existait qu'un seul pont. Au XIXème siècle, les Angevins ont canalisé la rivière en un unique chenal et construit des quais et deux autres ponts .
Aujourd'hui, les prairies inondables, difficilement constructibles, constituent pour Angers une précieuse réserve foncière. D'importants travaux d'aménagement sont en cours : remblaiement des prairies, plan d'eau, quatrième pont, voie express de berge et rénovation des bas quartiers. Ces mutations d'un célèbre paysage, qui posent un certain nombre de problèmes, suscitent des craintes que l'auteur juge excessives.
Les interrelations dans le tertiaire supérieur nantais. Étude sur la dynamisation d'une économie urbaine.
Authors: Mesnard Annie , Vigarié André 
Published: November 2022

Les entreprises de prestations de services dans les villes ne sont pas simplement juxtaposées ; elles sont réunies par des réseaux d'interrelations qui sont une nécessité fonctionnelle. L'étude cherche à analyser le "milieu" constitué par ces réseaux, en prenant comme exemple le cas de Nantes. Elle tend à déceler les mécanismes et les processus sous-jacents, la faculté de dynamisation ou de freinage que ce "milieu" peut avoir spontanément pour l'économie urbaine.
Le point de départ est constitué pour l'ensemble d'une enquête collective et de monographies de détail qui permettent d'aborder successivement : le cadre général que constitue l'ensemble tertiaire nantais, les formes générales des interrelations externes et internes, l'analyse aussi précise que possible des réseaux d'interrelations abordée par des méthodes nouvelles, les conséquences sur la centralité et la dynamisation urbaine de Nantes, avec en conclusion, la généralisation de ces problèmes.
L'industrialisation récente de l'agglomeration d’Angers. Un aménagement volontaire nécessaire dans l'activité professionnelle angevine : un nouvel espace industriel organisé et l'exemple d'un grand établissement intégré : l'usine Thomson.
Authors: Lazzarotti Raymond 
Published: November 2022

Angers a une situation économique intermédiaire, entre celle des métropoles et celle des espaces non métropolisés. La ville bénéficie de la poussée démographique importante de l'Anjou dans son ensemble, mais aussi la supporte. Pourtant, elle n'a disposé d'un développement et d'un équipement industriels valables que tardivement, lorsqu'elle a aménagé plusieurs zones industrielles, et lorsque l'accélération de l'exode rural lui a confié définitivement la mission de fournir un emploi urbain aux migrants des campagnes. La décentralisation des usines lui fournit une seconde occasion d'essor industriel : c'est l'autre thème d'étude principal, illustré par l'analyse des entreprises d'électronique (Thomson, Honeywell-Bull...). Les conséquences pour l'agglomération en sont
soulignées.
Culture post-urbaine à Los-Angelès
Authors: Brino Giovanni 
Published: November 2022

La croissance de Los Angeles jusqu’ici sans précédent et sans aucune autre analogie a fourni l'occasion de créer un modèle tout neuf de super-city, entièrement fondé sur le transport individuel, le seul qui soit vraiment adéquat par ses dimensions et par ses qualités d'environnement aux fins poursuivies par la nouvelle société de consommation.
La culture très particulière qui a commencé à se développer sur le territoire angélinien et qui a eu Hollywood comme matrice d'origine, peut être définie sans hésitation comme une culture post-urbaine dans la mesure où elle a su l'emporter sur la dichotomie existant entre la culture urbaine et la culture suburbaine, rendant par là possibles une forme et un fonctionnement de type urbain différent de celui conçu par les urbanistes traditionnels.
Du point de vue géographique, à cause de la totale artificialisation du territoire, Los Angelès a fini par se configurer comme le prototype le plus évident et en même temps le plus paradoxal de région volontaire, qui est le concept formulé par la géographie culturelle américaine la plus avancée pour désigner le modèle régional le plus antithétique à celui de région traditionnelle.
A propos de cette hypothèse de croissance du territoire, unique en son genre, l'auteur se demande quel sens peut encore avoir un terme traditionnel comme celui de planification (planning) et quel rôle effectif peut avoir joué un organisme administratif comme le Service de Planification Urbaine de Los Angelès dans la formation de l'image de la ville.
La maitrise de l'eau dans les près-marais de l'estuaire de la Loire : étude comparée.
Authors: Gras Jacques 
Published: November 2022

Water-control in the "marsh-meadows" of the Loire estuary : a comparative study.
The Loire estuary is fringed on both its Northern and Southern banks with plains that are partially occupied by large marshy areas communicating with the stream.
When the Loire is in spate, or swollen by the tide, or just during the heavy showers of the cold season, those marshes are flooded. In the hot season, on the contrary, they are usually free from water and open to the herds. Towards the end of summer they are often too dry and it becomes then necessary to send them water from the stream, when an exceptionnally hig tide occurs. Wood or metal water-gates, electrically or hand-operated, enable the producers grouped in associations to control the flow of water, to drain or irrigate as required.
Such systems are extremely old. The text studies the devices
built in the Middle-Ages (12th century) and especially in the 18th and
19th centuries. They have continually been improved, though not everywhere, and the survey describes the latest ones, which are much more important on the Southern bank, in the "Pays de Retz", than in the North.
Why do so many differences exist from one area to another ?
Is it because the Physical Geography of those "marsh-meadows", (which are never totally alike), demands the use of particular techniques for everyone of them ? Or does the North-South opposition reflect a historical situation dating back to two thousand years, when the Loire acted as a border between the Gallo-roman territories, and when the Aquitaine spread as far -as the
left bank ? Should those differences be accounted for in terms of Physical or in terms of mental habits ? Or both ?
L’industrie minière dans la mer : perspectives d’une recherche géographique
Authors: Spinelli Giorgio 
Published: November 2022

The exploitation of hydrocarbons and polymetallic nodules seems to become more and more promising. Anyway
the actual degree of knowledge on deep-sea mining resources and metallurgic technics on nodules suggest more cautious evaluations. Geography can give a valuable support to better understand the true chances of deep-sea mining, respect to same resources inshore, and their possible relations with the ports and coastal industries.
Les retombées sur les littoraux de l’exploitation offshore des hydrocarbures
Authors: Lerat Serge 
Published: November 2022

L’auteur souligne que l’offshore fournit actuellement le quart de la production mondiale de pétrole. Cela ne
peut pas ne pas entraîner de retombées sur les littoraux : directes sous la forme d’aménagement côtier, indirectes sous la forme des répercussions économiques diverses. D’où la possibilité d’établir une hiérarchie de ces retombées, dans laquelle il apparaît qu’elles sont d’autant plus importantes que le littoral était antérieurement plus développé.
Man and the Mediterranean Deltas
Authors: Varani Luigi 
Published: November 2022

Dans la Méditerranée les deltas des fleuves européens sont des extensions de formation «récente» : leur histoire
naturelle est synchrone à l’histoire de l’homme. En effet, pendant les derniers millénaires et plus encore pendant les derniers siècles, histoire naturelle et histoire humaine se sont révélées très interdépendantes. L’homme, avec le contrôle sur le réseau hydrographique et sur le drainage des eaux, n’a pas seulement créé de nouveaux espaces économiques, mais aussi est devenu un agent très important qui a dirigé la croissance et l’installation naturelle des deltas. De façon que, si pendant longtemps c’est le fleuve qui a dominé ce milieu amphibie, de nos jours c’est l’homme le protagoniste et l’organisateur de ces nouveaux espaces.
L’étude du rapport entre l’homme et les deltas des certains fleuves européens (Ebre, Rhône, Po, Tevere et Danube) a permis de voir et de comprendre les analogies et les différences pour ce qui concerne l’organisation économique. Aujourd’hui l’action humaine actualise certains problèmes de l’environnement de façon qu’on commence à considérer l’importance de la protection du milieu naturel des deltas au lieu de leur excessive exploitation.
Travaux et trafics sur les cours d’eau entre Loire et Vilaine vers 1852
Authors: Prioul Christian 
Published: November 2022

En 1855, E. Grangez fait paraître un «Précis historique et statistique des voies navigables de la France...». Son
exploitation dans un esprit géohistorique permet de dresser un tableau des travaux et des trafics entre Loire et Vilaine au moment précis de leur apogée. Ainsi se trouve mise en perspective la tendance contemporaine à transformer les «cours d’eau» en «plans d’eau».
TGV et trace des voies ferrées en Bretagne
Authors: Le Rhun Pierre-Yves 
Published: November 2022

Les performances du TGV sur les voies ferrées bretonnes seront médiocres. Une véritable concurrence entre le rail
et la route ne peut s’établir sans que l’on améliore le tracé des voies ferrées : l’héritage du Second Empire est devenu un facteur limitant qui contrarie les efforts de désenclavement ferroviaire. L’auteur propose des solutions permettant de tirer meilleur parti du TGV en Bretagne.
L’évolution quaternaire du relief au Costa Rica
Authors: Bergoeing J.P. 
Published: November 2022

Pays de montagnes, le Costa Rica se caractérise par différents types de modelés qui se disposent en paliers altitudinaux :
Entre 3.800 et 3.500 mètres d'altitude domaine du modelé paléo-glaciaire. de 3.500 à 2.800 mètres d’altitude : modelé paléo-nival. de 2.800 à 1.000 mètres d’altitude : modelé multifaces.
de 1.000 à 100 mètres d’altitude : modelé multiconvexe où foisonnent les cônes de déjections, terrasses fluviales, talus d’érosion et solifluxion généralisée. Au-dessous de 100 mètres d’altitude c’est le domaine des plaines inondables, comme la grande plaine du Nord (San Carlos) laquelle s’étale jusqu’au lac de Nicaragua et du rio San Juan (graben de Nicaragua).
Les différentes formes de modelés au Costa Rica sont les témoins de crises climatiques survenues pendant le Quaternaire. Elles se sont traduites par des phases rhexistasiques, donc plus arides et des phases biostasiques plus humides. Ceci a donné en altitude, des traces manifestes d’au moins une glaciation récente (Wurm terminal), sur les hauts sommets de la Cordillère de Talamanca et notamment au Cerro Chiripo (3.819 m).
Le Haut Pays de Retz : Un espace en voie de dévitalisation ?
Authors: Jaulin Jacques 
Published: November 2022

An observation of population figures and an analysis of economic activity show the district of Legé and its neighbouring municipalities to be an area in the process of losing its vitality.
Explanations for this are to be found in Legé’s geographical position, its isolation, and the passivity of its leading citizens.
In spite of efforts to bring about a development of its amenities, the situation remains disconcerting.
Pouvoir associatif et pouvoir local : Quelles mutations dans les sociétés péri-urbaines ?
Authors: Guimbretière Dominique 
Published: November 2022

L’arrivée de nouvelles populations dans les communes rurales proches des villes modifie les rapports sociaux.
L’analyse des associations est un indicateur de changements socio-politiques et un révélateur des conflits et du degré d’intégration.
L’exemple des communes péri-urbaines de la Roche-sur-Yon montre les difficultés de l’insertion des populations nouvelles, notamment pour la conquête du pouvoir communal.