bluuebunny/crossref_metadata_2025_split huggingface dataset:
CXCL13-CXCR5 axis：regulation in inflammatory diseases and cancer
Authors: binhan wang , Wang Manni , Ao Danyi , Wei Xiawei 
Published: June 2022

Abstract
Chemokine C-X-C motif ligand 13 (CXCL13), originally identified as a B-cell chemokine, leads to the homing of B cells and follicular helper T cells and plays an important role in the immune system. The interaction between CXCL13 and its receptor, the G-protein coupled receptor (GPCR) CXCR5, contributes to the formation of lymphoid follicle. The CXCL13-CXCR5 axis makes vital function to build a signaling network that regulates not only normal organisms but also the development of many diseases. However, the precise action mechanism remains unclear. In this review, we discussed the functional mechanisms of the CXCL13-CXCR5 axis under normal conditions, with special focus on its association with several diseases, such as inflammatory diseases and cancer. This axis exerts a role in promoting or inhibiting the development of these disease. At the end, for certain refractory diseases, we focus on the diagnostic and therapeutic role of CXCL13-CXCR5 axis. In particular, it aims to improve disease conditions and prolong survival by targeting various targets in this axis.
A case of abnormally dilated and tortuous Arc of Buhler and Pancreaticoduodenal arteries in the absence of Celiac Trunk stenosis
Authors: Rathod Sonali , Kolus Riley , Kim Byungchan , Gurnani Sarika , Kim Andy , Kim Erin , Tan Faisal , Roy Isabelle , Whitney Elizabeth , Wisco Jonathan 
Published: June 2022

Abstract
The Arc of Buhler is a vascular variant describing a persistent remnant of the embryologic ventral anastomosis between the celiac trunk (CT) and superior mesenteric artery (SMA). Prevalence of the Arc of Buhler is estimated to be 3% of the population with only half of those cases being hemodynamically active, invariably reported in the context of CT stenosis. We encountered a case of 1) an abnormally large and tortuous pancreaticoduodenal arcade 2) a large and tortuous Arc of Buhler in the absence of celiac axis stenosis. Absent any evidence of CT stenosis in our donor, this finding represents a previously unreported case of dilated and tortuous anastomotic connections between the celiac axis and the SMA without any obvious causative factors. Due to the abnormal position and tortuous characteristics of this aberrant vessel and the associated prevalence of Arc of Buhler, it is important for clinicians to be aware that this type of anomaly may be present in the general population. The abnormal position may increase risks of herniation and surgical complications, and the tortuous nature may cause increased risk of clot formation. Thus, it is essential that surgeons are aware of such examples of abnormal anatomy both for perioperative considerations and clinical identification of future pathologies. Purpose: To report a case of a persistent, hemodynamically active Arc of Buhler in the absence of CT stenosis. Methods: The variant was discovered during routine cadaver dissection. We acquired transverse biopsies of variant vessels and evaluated their wall thickness. Results: The donor’s anterior PDA, posterior PDA, and Arc of Buhler had larger diameters than literature reported values of a standard human body. Additionally, the posterior PDA had significantly increased wall thickness compared to the other investigated vessels. The common hepatic artery was smaller in diameter than the literature reported ranges. The splenic artery diameter was within the literature reported range. Conclusion: The Arc of Buhler is a remnant of the embryologic ventral anastomosis that is estimated to be present in 3% of the population, but hemodynamically active in only half of those cases. Previous reports have documented hemodynamically active Arcs of Buhler only in cases of CT stenosis. To the best of the authors’ knowledge, this is the first reported case of persistent and hemodynamically active Arc of Buhler in the absence of CT stenosis.
Biomechanics Beyond the Lab: Remote Technology for Osteoarthritis Patient Data - A Scoping Review
Authors: Hamilton Rebecca I. , Williams Jenny , Consortium OATech Network+ , Holt Cathy 
Published: June 2022

Abstract

The objective of the project was to produce a review of available and validated technology suitable for gathering biomechanical and functional research data in patients with osteoarthritis (OA), outside of a traditional fixed laboratory setting. A scoping review was conducted using defined search terms across three databases (SCOPUS, OVID MEDLINE, and PEDRO) and additional sources of information from grey literature were added. One author carried out an initial title and abstract review, and two authors independently completed full text screenings. Out of the total 5,164 articles screened, 75 were included based on inclusion criteria covering a range of technologies in articles published from 2015. These were subsequently categorised by technology type (wearables-IMUs, wearables-other, insoles/platforms and cameras) and metric (kinematic and spatiotemporal measures (SPTs), kinetic and SPTs, joint angles/ROM only and EMG), and as suitable for portable, part remote or remote use. Those technologies that are commercially available were also identified. Results concluded that from the growing number of available and emerging technologies, there is a well-established range in use. These are primarily inertial measurement units, as well as other wearables and camera-based technologies, particularly for collection of gait SPTs. Results demonstrate that biomechanical and functional remote data collection is both feasible and has growing potential for OA researchers.
BEZ235 enhances antitumor efficacy of HPG-PCL-PTX in HCC by suppressed the PI3K/Akt/mTOR and MAPK pathway
Authors: Liu Xueke , wu Yingping , Xu We , Li Lele , Xia Xiaoping , Tang Xiaolong 
Published: June 2022

Abstract

Hepatocellular carcinoma (HCC) is the sixth most common cancer in the global. It could be a potential resistant mechanism that paclitaxel activated the PI3K/mTOR and MAPK pathway in HCC cells. So inhibiting the abnormal activation of two pathway, which may a promising targeted therapy strategy. MTT and clone formation assays were used to measure cells proliferation activity; cell cycle distribution and apoptosis were measured by flow cytometry; western blot assessed phosphorylation level of proteins associated with cell cycle, apoptosis, PI3K/mTOR and MAPK pathway; Student t test or one-way ANOVA to measure significant differences between the means.BEZ235 combined with HPG-PCL-PTX blocked the activation of PI3K/mTOR and MAPK pathway in HCC cells, effectively inhibited cells proliferation and arrested the cell cycle at the G2/M phase. The most important is that the combination of two drugs caused mitochondrial membrane potential change, induced cytochrome C release and bind to APAF-1 to initiate the caspase-9 apoptosis program, promoted HCC cell apoptosis. HPG-PCL-PTX/BEZ235 enhanced antitumor effectiveness in HepG2R cell xenograft mouse models. In vivo study suggested that BEZ235 combined with HPG-PCL-PTX enhanced effects of HPG-PCL-PTX through inhibited the PI3K/Akt/mTOR and MAPK pathway in HCC cells, supressed cells proliferation, arrested the cell cycle in a G2/M phase and promoted apoptosis. Antitumor effects of BEZ235 and HPG-PCL-PTX were also confirmed in mice bearing HepG2R tumors. Taken together, the results of this study describe a promising strategy using PTX and BEZ235 in a nanoparticle formulation for treatment of PTX-resistant HCC.
Establishment of in vitro shoot tips regeneration system of foxtail millet and obtainment of transgenic plants of SiSERK1
Authors: Guofan Wu , Wenbo Li , Nongfu Tian , Wangze Wu , Ning Yang 
Published: June 2022

Abstract

Foxtail millet (Setaria italica) would be suitable as a model plant of C4 plants given its small genome (about 490 MB) and diploid self-pollination. However, the study of foxtail millet faces the problem of low efficiency of explant regeneration and genetic transformation. In this study, a new genetic transformation system of Yugu1 foxtail millet was established with in vitro shoot tips as the explant, and, the concentrations of 6-BA and kanamycin were optimized. Thus, 0.5 mg•L-1 6-BA and 25 mg•L-1 kanamycin were the most suitable in terms of the differentiation rate of shoot tips and survival rate of differentiated seedlings. In addition, 12 transgenic foxtail millets of SiSERK1 were identified by resistance screening and PCR and identified the insertion site of one of the transgenic plants. The results of qRT-PCR showed that the expression of SiSERK1 gene in plants transformed was significantly higher than that in wild-type plants. A new method of generation of material for further study of SiSERKs is provided for foxtail millet genetics and breeding.
Polymorphisms in Plasmodium falciparum Dihydropteroate Synthetase (540pfdhps) Gene Responsible for Sulphadoxine–pyrimethamine Resistant Malaria in Jos, Nigeria
Authors: Nwankwo Nelson Jehosephat , KuKui Joel Paul , Longdet Ishaya Yohanna , Kutshik Richard Joseph 
Published: June 2022

Abstract
BackgroundThe World Health Organization (WHO) recommends sulfadoxine–pyrimethamine (SP) for use as an intermittent preventive medication in malaria-endemic regions to help reduce the global malaria burden in a susceptible population. The therapeutic efficacy of the SP is impaired by growing SP resistance (SPR). Resistance to sulphadoxine and pyrimethamine has previously been linked to mutations in the dihydrofolate reductase (dhfr) and dihydropteroate synthetase (dhps) genes. As a result, molecular research into Plasmodium falciparum's genetic makeup will aid in the development of new antimalarial medications as well as the improvement of existing ones.MethodsThe dihydropteroate Synthetase gene (dhps) was used as a marker to study SP resistance in 100 malaria cases. The DNA of the parasite was isolated from whole blood samples obtained and kept in EDTA bottles using the Zymo extraction kits' technique. PCR and gel electrophoresis were used to identify the Plasmodium genus, Plasmodium falciparum, and the 540-dihydropteroate synthetase gene. Sangar sequencing was utilized for sequencing, and nucleotide blast, blastx, and querry-anchored alignment view with dot of the NCBI tool were employed for bioinformatic analysis.ResultsOnly 50% of the clinically tested samples were positive for Plasmodium genus, 96% for Plasmodium falciparum, and point mutations in the pfdhps gene at codon K540E in 16.67% of the isolates, according to the findings. The sequence alignment of the parasite gene's resultant nucleotide indicates a point mutation in the nucleotide sequence. Despite the fact that a point mutation occurred in the DNA's coding region, there is no mutation when the nucleotide sequence is translated into amino acids.ConclusionPlasmodium falciparum is the most common malaria species in Jos, with more than nine out of 10 (96%) malaria patients testing positive for the parasite. The discovered mutation has no influence on the amino acid sequence, and consequently has no effect on the protein's functionality. It's possible that the reported resistance isn't attributable to a mutation in the 540-dihydropteroate synthetase gene, but rather to other factors mentioned in the literature.Trial RegistrationPlateau Specialist Hospital's institutional review committee/boards accepted the research protocol, and ethical clearance was obtained. NHREC/05/01/2010b is the registration number, and it was obtained on December 11, 2019.
Access to Micro Finance Credit and its Impact on Farm Productivity of Rural Households: The Case of Machakel Woreda, Amhara Region, Ethiopia
Authors: Adamu Heruy 
Published: June 2022

Abstract
Agriculture is the main livelihood of Ethiopians and it is characterized by its low productivity and traditional backward way of production. The main objective of this paper is to analyze access to microfinance credit and its impact on the farm productivity of rural households in Machakel woreda east Gojjam zone, Ethiopia. Multistage sampling technique was employed to select sample respondents from the total population. Quantitative type of data was collected from primary and secondary sources available. A structured questionnaire was used as the main instrument of primary data collection. Using a cross-sectional data related to the fiscal year 2019/20, standard Tobit model was utilized to analyze the determinants of credit access and endogenous switching regression model was employed to evaluate the impact of credit on farm productivity. The result in the Tobit model shows that the amount of credit is positively and significantly affected by enterprise ownership, bank account, age of the household head, educational status, output per hectare, and the value of house while family size found to affect it negatively and significantly. The result from endogenous switching regression analysis shows that, the treatment is endogenous to the outcome variable. Taking into account this endogeneity problem, the study estimates the treatment effect of credit on farm productivity. The estimated treatment effect result shows that output per-hectare of credit user households is 38.05 percent more than their non-user counterparts which implies that keeping other things remain constant credit can improve the productivity of households by 38.05percent in the study area. Finally, since credit is crucial for farm productivity, the study recommends the concerned bodies to arrange the way to access formal agricultural credit for rural households.
The correlation between fractional amplitude of low-frequency fluctuation-based resting-state functional magnetic resonance imaging and facial emotion recognition ability in patients with first-episode schizophrenia
Authors: Kuang Qijie , Zhou Sumiao , Li Haijing , Mi Lin , Zheng Yingjun , She Shenglin 
Published: June 2022

Abstract
It was still unclear that the correlation between the resting-state intrinsic activity in brain regions and facial emotion recognition (FER) ability in patients with first-episode schizophrenia (FSZ). Our aim was to analyse the correlation between the fractional amplitude of low-frequency fluctuation (fALFF) and FER ability in FSZ patients. A total of 28 patients with FSZ and 33 healthy controls (HCs) completed visual search tasks for FER ability. Regions of interest (ROIs) related to facial emotion were obtained from a previous meta-analysis. Pearson correlation analysis was performed to understand the correlation between fALFF and FER ability. Our results indicated that the patients performed worse than the HCs in the accuracy performances of happy FER and fearful FER. The previous meta-analysis results showed that the brain regions related to FER included the bilateral amygdala (AMY)/hippocampus (HIP), right fusiform gyrus (FFG), and right supplementary motor area (SMA). Pearson correlation showed that the fALFF of the right FFG was associated with high-load fearful FER accuracy (r = -0.43, p = 0.022). Multiple regression analysis showed that the fALFF of the right FFG was an independent contributor to fearful FER accuracy (low-load task: B = -0.40, t = -2.29, p = 0.034; high-load task: B = -0.46, t = -3.30, p = 0.004). Our study indicated that FER ability is correlated with resting-state intrinsic activity in brain regions related to facial emotion, which may provide a reference for the study of FER in schizophrenia.
Marco metodológico para el diseño de rúbricas analíticas
Authors: Neil Carlos , Battaglia Nicolas , De Vincenzi Zemborain Marcelo Edgardo 
Published: June 2022

La rúbrica es un instrumento de evaluación que permite determinar el nivel de logro en la resolución de problemas relacionando una serie de indicadores con descriptores de niveles de dominio. Permite evaluar y sistematizar el grado de dominio de las competencias y valorar aspectos complejos, imprecisos y subjetivos. Si bien es una herramienta muy difundida en el ámbito educativo, su utilidad se ve diezmada al no establecerse criterios claros para la determinación de sus componentes, en particular los descriptores. En este trabajo desarrollamos un marco metodológico para el diseño de rúbricas analíticas que abarca todas las actividades, desde la determinación del objeto de estudio hasta la especificación de sus componentes, finalizando con su implementación Web. Proponemos un marco metodológico en un proceso iterativo e incremental que permita establecer criterios explícitos y lineamientos claros para determinar, tanto las etapas a seguir, como sus componentes. El principal beneficio será establecer un proceso para el diseño de rúbricas analíticas que permitirá generalizar su aplicación en los procesos de evaluación formativa y complementar su uso como una estrategia de aprendizaje.
Análisis de un entorno tecnológico diseñado durante la pandemia para fomentar la autorregulación del aprendizaje en educación preuniversitaria
Authors: González Carlos 
Published: June 2022

En marzo de 2020 se decreta el confinamiento con el cierre de todos los centros educativos españoles. Esta situación provoca que los centros tengan que idear metodologías para implantar el aprendizaje a distancia. El presente artículo se centra en la Etapa de Bachillerato de un centro de Baleares, que cuenta con 300 alumnos/as y 20 profesores/as.
En este artículo se muestran los resultados de un estudio realizado, que se centra en identificar y realizar un análisis mixto, a través de la metodología de estudio de caso de tipo intrínseco, los elementos de la autorregulación del aprendizaje favorecidos por el entorno enriquecido por tecnología implementado durante el confinamiento, debido a la COVID.
Los resultados y la discusión de los mismos permiten establecer los elementos, herramientas y metodologías del entorno diseñado que han influido sobre la autorregulación del aprendizaje del alumnado: el papel del docente, la actitud del alumnado y sus expectativas de autoeficacia, la planificación estratégica y las herramientas que permiten la interacción social y la reflexión en común.
Estos mismos resultados, han servido para establecer las pautas de una metodología que permita favorecer dichos aspectos una vez finalizado el confinamiento.
Metal leaching test of commercially available faucets in the Japanese market in 2016–2020
Authors: Miyoshi Taro , Simazaki Dai , Tokuyasu Marina , Masuda Takanori , Akiba Michihiro 
Published: June 2022

Abstract
In this study, metal leaching was investigated in commercially available faucets in Japan to clarify their compliance to Japanese regulations. We purchased 37 faucets from the market and analyzed the leaching of cadmium, mercury, selenium, lead (Pb), arsenic, hexavalent chromium, boron, zinc (Zn), copper, manganese, and nickel. The leaching tests were performed with and without a conditioning treatment, that simulated approximately 1-month intermittent use of faucets on weekdays, and the results were compared to estimate the changes in metal leaching during the use of faucets. The results revealed that metal leaching from most of the faucets complied with Japanese regulations. However, the levels of Pb leaching from several faucets produced by certain manufacturers exceeded the Japanese standard. The conditioning treatment was generally effective in reducing metal leaching. However, the reductions in Pb and Zn leaching tended to be lower than those of the other metals. Nickel is not legally regulated in Japan; although the number of cases where nickel concentration in leachate exceeded the water quality management target value was greater, such cases were limited to faucets primarily made of copper alloys. We believe that these results will be helpful to improve the public health associated with metal leaching from faucets.
NEED ASSESSMENT PEMBELAJARAN AKUNTANSI SELAMA MASA PANDEMI COVID-19 PADA JURUSAN S1 PENDIDIKAN AKUNTANSI FE UNY
Authors: Aghni Rizqi Ilyasa , Siswanto Siswanto , Siregar Merinda Noorma Novida , Purnama Dian Normalitasari 
Published: June 2022

Penelitian bertujuan mengetahui kebutuhan pembelajaran Akuntansi di masa pandemi Covid-19, yang meliputi: 1) Bagaimana pelaksanaan pembelajaran; 2) Kendala yang dialami mahasiswa; 3) Kendala yang dialami dosen; 4) Kebutuhan mahasiswa untuk menunjang pembelajaran daring; 5) Kebutuhan dosen untuk menunjang pembelajaran daring. Penelitian dilaksanakan di Jurusan S1 Pendidikan Akuntansi FE UNY selama Februari-Juli 2021. Penelitian ini merupakan penelitian deskriptif eksploratorif dengan teknik pengumpulan data berupa angket. Teknik analisis data menggunakan analisis deskriptif kualitatif dan kuantitatif. Hasil penelitian menunjukkan: 1) Pembelajaran Akuntansi dilaksanakan dengan platform media seperti Besmart, Zoom, G-meet. Media pembelajaran yang digunakan antara lain modul PDF, powerpoint, video tutorial, video youtube, dan media lain sebagai penunjang proses pembelajaran bagi mahasiswa secara mandiri; 2) Kendala yang dihadapi mahasiswa adalah kurangnya bahan ajar dan kuota internet, kesulitan jaringan, kurang paham materi, dan fasilitas kurang memadai; 3) Kendala paling banyak dialami dosen adalah banyak mahasiswa pasif ketika dosen menjelaskan; 4) Kebutuhan mahasiswa untuk menunjang pembelajaran daring meliputi buku, modul PDF, video Youtube, Powerpoint, artikel jurnal, kestabilan jaringan, kuota internet, gadget, lingkungan yang mendukung, dan platform pembelajaran; 5) Kebutuhan dosen untuk menunjang pembelajaran adalah buku pegangan, modul praktikum PDF, fasilitas internet yang memadai, artikel jurnal, platform pembelajaran, serta kemampuan membuat media pembelajaran yang menarik dan interaktif. Kata Kunci: Need Assessment, Pembelajaran Daring Akuntansi, Masa Pandemi Covid-19
STATE OF CARBOHYDRATE METABOLISM AND INSULIN CONCENTRATION IN BLOOD IN PATIENTS WITH PUBERTIVE UTERINE BLEEDING
Authors: Shcherbina M. O. , Dinnik O. O. , Gulyaeva V. G. 
Published: June 2022

The state of carbohydrate metabolism, the level of immunoreactive insulin in patients with pubertal uterine bleeding, taking into account body weight, was studied. The obtained data show that in a certain part
subjects have a violation of carbohydrate metabolism, hyperinsulinemia and insulin resistance. Most often, these changes are registered in patients with excess body weight, although observed in patients with physiological growth and weight, and with a deficit of body weight.
THE ROLE OF LEPTIN AND ADIPONEKTIN IN FORMATION INSULIN RESISTANCE IN CHILDREN OF PUBERTIC AGE, WHO SUFFER FROM OBESITY
Authors: Shlyakhova N. V. 
Published: June 2022

Serum leptin and adiponectin concentrations in obese children were determined (65
children with insulin resistance and 55 children without its symptoms), as well as 25 of their peers with normal
weight. It is established that obesity in children is accompanied by increased production of leptin and
reduced - adiponectin, the changes of which are more pronounced in children with insulin resistance. Level
leptin is associated with body mass index regardless of the presence of insulin resistance, and the content
adiponectin is associated with body mass index only in children with insulin resistance.
PECULIARITIES OF CONDUCTING PSYCHOLOGICAL REHABILITATION OF CHILDREN, PATIENTS WITH TYPE 1 DIABETES MELLITUS
Authors: Demchenko O. A. , Mikhailova E. A. , Khizhnyak Oksana 
Published: June 2022

The paper presents data on the feasibility of application and psychological effectiveness
rehabilitation of children with type 1 diabetes mellitus. Based on the selected types of family relationships, the level of anxiety and neuroticism of patients and their mothers, an algorithm is proposed
psychocorrection and the degree of compensation of diabetes mellitus in the dynamics of observation due to
6 and 12 months. It is proved that the application of the Psycho-educational program of problem-targeted education of patients in combination with differentiated psychotherapy significantly improves glycemic
control and general course of type 1 diabetes mellitus in school-age children.