bluuebunny/crossref_metadata_2025_split huggingface dataset:
Posterior-only debridement, bone fusion, single-segment versus short-segment instrumentation for mono-segmental lumbar or lumbosacral pyogenic vertebral osteomyelitis: minimum five year follow-up outcomes
Authors: Zhang Hong-Qi , Wang Yu-Xiang , Guo Chao-feng , Tang Ming-xing , Liu Shao-hua , Deng Ang , Gao Qile 
Published: August 2022

Abstract
Background
Pyogenic vertebral osteomyelitis (PVO), which is a potentially life-threatening condition and is associated with significant morbidity and mortality, is a cause of back pain that can lead to neurologic deficits if not diagnosed in time and effectively treated. The objective of this study is to compare the efficacy of posterior single-segment and short-segment fixation combined with one-stage posterior debridement and fusion for the treatment of mono-segmental lumbar or lumbosacral PVO.

Methods
Charts of all patients with mono-segmental lumbar or lumbosacral PVO were treated by single-stage posterior debridement, bone graft fusion, and pedicle screw fixation from April 2012 to January 2016. All patients were divided into two groups: sinlge-segment fixation (Group A, n = 31) and short-segment fixation (Group B, n = 36). These patients were followed up for a minimum of five years. The clinical efficacy was evaluated and compared on average operation time, blood loss, visual analog scale (VAS), erythrocyte sedimentation rate (ESR), C-Reactive protein (CRP), neurological function recovery and local lordotic angle.

Results
All 67 patients were completely cured during the follow-up. All patients had significant improvement of neurological condition and pain relief at the final follow-up. The VAS was 7.1 ± 0.7 in group A and 7.2 ± 0.6 in group B pre-operatively, which decreased to 2.1 ± 0.6 and 2.0 ± 0.7, respectively, at three months after surgery, then reduced to 0.4 ± 0.5 and 0.5 ± 0.5, respectively, at the final follow-up. ESR, CRP returned to normal limits in all patients 3 months after surgery. The mean blood loss and operation time in group A were less than that in group B (P < 0.05). The local lordotic angle in group A was increased from preoperative − 1.7 ± 7.9° to postoperative 5.8 ± 7.1°, with angle loss of 1.5 ± 0.8° at the final follow-up, respectively (P < 0.05). The local lordotic angle in group B was increased from preoperative − 1.6 ± 7.8° to postoperative 13.5 ± 6.2°, with angle loss of 1.3 ± 0.8° at the final follow-up, respectively (P < 0.05). In the mean postoperative local lordotic angle, there was significant difference between the two groups at the time of immediate postoperative period or the final follow-up (P < 0.05).

Conclusion
Posterior-only debridement, interbody graft using titanium mesh cage, posterior single-segment instrumentation and fusion represent a safe and effective treatment option for selected patients with mono-segmental lumbar and lumbosacral PVO. This approach may preserve more lumbar normal motor units with less blood loss and operation time when compared with that of short-segment fixation. But short-segment fixation was superior to the single-segment fixation in the correction of kyphosis.
Letter to the editor regarding “Epidemiologic analysis of 8000 acute vertebral fractures: evolution of treatment and complications at 10-year follow-up”
Authors: Doll Dietrich , Luedi Markus M. 
Published: August 2022

AbstractIn this letter to the editor, we discuss the article by Bigdon et al., published recently in the Journal of Orthopaedic Surgery and Research, about their accurate single-centre cohort study of 8000 vertebral fractures in 4772 patients. As the complication rate of this cohort is low, it seems that severe trauma patients needing damage control resuscitation/procedures may have undergone damage control in the first treating hospital before being transferred to the trauma centre. It will be interesting to see how both activity and health trends within the ageing population will change osteoporotic occurrence of fractures and enable more conservative trends versus operative stabilization to continue an active life even in the seventh or eighth decade.
Validation of the Behavioral Anger Response Questionnaire for Children (BARQ-C) in a large community sample of Vietnamese middle adolescents in Hanoi
Authors: Shochet Ian , Orr Jayne , Cockshaw Wendell , Tran Thach , La Nga , Nguyen Huong , Nguyen Nga , Wurfl Astrid , Nguyen Hau , Stocker Ruby , Fisher Jane 
Published: August 2022

Abstract
Background
Depression and other forms of psychological distress are common among Vietnamese adolescents and increase the risk of mental health problems in adulthood. As anger coping is a robust predictor of adolescent mental health difficulties, and there appear to be cultural variations in anger coping, a measure of adolescent anger coping styles that has been validated using a non-Western adolescent sample is required to inform and support early intervention to prevent or treat mental health difficulties in Vietnamese adolescents. This study examined the construct validity (structural and external) of the Behavioral Anger Response Questionnaire for Children in Vietnam (BARQC-V).

Methods
Baseline data sourced from a recent randomised control trial conducted with Grade 10 Vietnamese adolescents aged 14 to 16 (N = 1084) were used to examine multiple aspects of construct validity: factorial structure (evaluated using factor analysis); internal consistency (tested using Cronbach’s alpha coefficient); and external aspect (assessed using Pearson’s correlation coefficients between the BARQC-V and Vietnamese translations of the Coping Self-Efficacy Scale, Centre for Epidemiologic Studies Depression Scale Revised, Mental Health Continuum Short Form, and the Depression Anxiety and Stress Scale).

Results
Evaluating factorial structure using confirmatory factor analysis failed to converge on a solution. Exploratory factor analysis yielded a 5-factor structure model that explained 49.32% of the BARQC-V’s total variance and was deemed to be a good fit by the final confirmatory factor analysis. Cronbach’s alpha coefficients of the 5 factors demonstrated acceptable internal reliability for the BARQC-V’s sub-scales. Concerning concurrent validity, three sub-scales predicted well-being and mental health difficulties: the maladaptive anger coping styles Rumination and Direct Anger-out were positively associated with depression and distress, and negatively associated with coping self-efficacy and mental well-being; and the adaptive anger coping style Assertion was positively associated with coping self-efficacy and mental well-being, and negatively associated with depression.

Conclusions
The BARQC-V provides a validated measure of three anger coping strategies used by adolescents in Vietnam (Rumination, Direct Anger-out, and Assertion) that can be used to improve detection and treatment of mental health difficulties in this population, and as a starting point by future research to develop a much-needed gold standard measure of anger coping for adults, adolescents and children world-wide.
Global Myeloma Trial Participation and Drug Access in the Era of Novel Therapies
Authors: Fatoki Raleigh Ayoolu , Koehn Kelly , Kelkar Amar , Al Hadidi Samer , Mehra Nikita , Mian Hira , Landgren Ola , Kazandjian Dickran , Hoffman James , Sborov Douglas W. , Mohyuddin Ghulam Rehman 
Published: August 2022

PURPOSE The globalization of clinical trials has accelerated recent advances in multiple myeloma (MM). However, it is unclear whether trial enrollment locations are reflective of the global burden of MM and whether access to novel therapies is timely and equitable for countries that participate in those trials. METHODS To assess this, we characterized where MM trials that led to US Food and Drug Administration (FDA) approvals were conducted and determined how often and quickly these drug regimens received approval in their participating trial countries on the basis of country income level and geographic region. RESULTS A systematic review was conducted to identify all MM clinical trials that met their primary endpoint, enrolled patients outside the United States, and resulted in FDA approval from 2005 to 2019. A total of 18 pivotal MM clinical trials were identified. High-income countries enrolled patients in 100% (18/18) of the trials identified, whereas upper-middle and lower-middle-income countries were represented in 61% (11/18) and 28% (5/18) of trials, respectively. No patients from low-income countries were enrolled. One trial enrolled patients in sub-Saharan Africa, and no trials enrolled patients in South Asia/Caribbean. For drugs/regimens that were approved in their participating countries, the median time from FDA approval to approval was 10.9 months. There were no drugs approved in lower-middle-income trial countries. MM trials leading to FDA approval are generally run in high-income, European, and Central Asian countries. CONCLUSION There are substantial disparities in where novel therapies are evaluated and where they are ultimately approved for use on the basis of income level and geography.
Palestinian American Women’s Marriages within and beyond Borders
Authors: Othman Enaya Hammad 
Published: August 2022

Abstract
This article explores American Palestinian women’s discursive strategies and identity politics by which they take control of their marital choices. Through the analysis of sixteen in-depth interviews with second-generation Palestinian women and personal observations within the community, the article shows that nationalist and religious discourses produced by the historical contexts respectively stimulated (semi)arranged in-group marriages in the 1990s and self-initiated exogamous marriages as of the early 2000s. Among the group, Islam has become the primary form of identification, and religious discourse has been circulating within Islamic institutions post-1980s. Based on this transformation, the study draws on the strategic use of religious sentiments and Islamic discourse and argues that women’s prioritization of Islamic identity has increased their agency in spouse selection and marriage process. Women’s negotiations within an Islamic framework also expose the ways Muslim women counter and redefine gender roles by fortifying their religious beliefs and reinterpreting Islamic doctrine.
Drug susceptibility profiling and genetic determinants of drug resistance in Mycobacterium simiae isolates obtained from regional tuberculosis reference laboratories of Iran
Authors: Daneshfar Sara , Khosravi Azar Dokht , Hashemzadeh Mohammad 
Published: August 2022

Background
Among Non-tuberculous mycobacteria (NTM) which generally cause opportunistic infections, especially in immunocompromised hosts, Mycobacterium simiae (M. simiae) is one of the most important NTM, associated with pulmonary disease. The main concern about M. simiae infections is the extreme resistance of this NTM to antibiotics. There are limited studies about drug susceptibility testing (DST) and the causes of drug resistance in M. simiae. Hence, the current study aimed to identify the M. simiae isolates and to assess the drug resistance of the isolates using phenotypic and molecular methods.

Materials and methods
In this study, 50 clinical pulmonary isolates suspected of NTM were collected from regional tuberculosis reference laboratories in Iran. The isolates were identified as M. simiae by using standard biochemical tests and molecular methods. DST was performed for identified M. simiae isolates and additional 35 M. simiae isolates from the department archive, against eight drugs. The mutations in gyrA, gyrB, and rrl genes in clarithromycin and moxifloxacin resistant isolates were investigated by polymerase chain reaction (PCR) followed by sequencing.

Results
Out of 50 suspected NTM isolates, 25 isolates were detected as M. simiae species based on the biochemical tests, and 18 isolates were verified based on the rpoB gene sequence analysis to achieve a total of 53 isolates when the archive isolates were included. DST results showed that all 53 isolates were resistant to isoniazid, rifampin, and clofazimine. The rate of resistance to ethambutol and linezolid were 34 (64%), and 40 (76%) respectively. The highest susceptibility rate was demonstrated for amikacin 53 (100%) and clarithromycin 45(85%), followed by moxifloxacin 35(66%). Sequence analysis showed mutations in positions 2058 and 2059 of the rrl gene, as well non-synonymous mutation at codons 389, 444, and 571 of the gyrB gene. Sequence analysis showed no mutation in the gyrA gene. drug-resistant isolates with mutations showed higher MICs compared to non-mutant resistant isolates.

Conclusions
This study revealed amikacin, clarithromycin, and moxifloxacin as the most effective antibiotics. However, since M. simiae exhibited a high level of antibiotic resistance in vitro, therefore, species identification and determining the antibiotic susceptibility pattern of the isolates are essential before treatment.
Subjective COVID-19-related work factors predict stress, burnout, and depression among healthcare workers during the COVID-19 pandemic but not objective factors
Authors: Spányik András , Simon Dávid , Rigó Adrien , Griffiths Mark D. , Demetrovics Zsolt 
Published: August 2022

Background
Work-related stress is significantly higher among healthcare workers (HCWs) than in the general population. Elevated occupational stress has been linked to burnout syndrome and depression. Moreover, medical professionals working during infectious disease outbreaks are at especially high risk for these problems. The aim of the present study was to examine the mental health status of HCWs and possible predictors of mental health status related to the COVID-19 outbreak utilizing a complex comprehensive model.

Methods
In a countrywide cross-sectional survey among HCWs (N = 2087), work-related stress, COVID-19 -related objective work factors (displacement, frontline working) and subjective work factors (insecurity, unpredictability, workload), perceived stress, work-related stress, burnout and depression were assessed between the second and third wave of COVID-19 pandemic in Hungary.

Results
COVID-19-related objective factors did not predict directly stress, burnout, and depression, whereas feelings of insecurity and unpredictability in relation to the COVID-19 situation at work had a significant medium-sized total effect (also considering the indirect effect via stress) on burnout and depression.

Conclusions
In order to prevent subsequent mental health problems during crisis situations, such as the COVID-19 pandemic, healthcare management should create a more predictable work environment and a safer work experience for healthcare workers and provide mental health support.
Measurement challenges and causes of incomplete results reporting of biomedical animal studies: Results from an interview study
Authors: Bruckner Till , Wieschowski Susanne , Heider Miriam , Deutsch Susanne , Drude Natascha , Tölch Ulf , Bleich André , Tolba René , Strech Daniel 
Published: August 2022

Background
Existing evidence indicates that a significant amount of biomedical research involving animals remains unpublished. At the same time, we lack standards for measuring the extent of results reporting in animal research. Publication rates may vary significantly depending on the level of measurement such as an entire animal study, individual experiments within a study, or the number of animals used.

Methods
Drawing on semi-structured interviews with 18 experts and qualitative content analysis, we investigated challenges and opportunities for the measurement of incomplete reporting of biomedical animal research with specific reference to the German situation. We further investigate causes of incomplete reporting.

Results
The in-depth expert interviews revealed several reasons for why incomplete reporting in animal research is difficult to measure at all levels under the current circumstances. While precise quantification based on regulatory approval documentation is feasible at the level of entire studies, measuring incomplete reporting at the more individual experiment and animal levels presents formidable challenges. Expert-interviews further identified six drivers of incomplete reporting of results in animal research. Four of these are well documented in other fields of research: a lack of incentives to report non-positive results, pressures to ‘deliver’ positive results, perceptions that some data do not add value, and commercial pressures. The fifth driver, reputational concerns, appears to be far more salient in animal research than in human clinical trials. The final driver, socio-political pressures, may be unique to the field.

Discussion
Stakeholders in animal research should collaborate to develop a clear conceptualisation of complete reporting in animal research, facilitate valid measurements of the phenomenon, and develop incentives and rewards to overcome the causes for incomplete reporting.
Outdoor School: Contemporary Environmental Art, Diane Borsato and Amish Morrell (Eds)
Authors: Modigliani Leah 
Published: August 2022

Review of: Outdoor School: Contemporary Environmental Art, Diane Borsato and Amish Morrell (Eds)
Madeira Park, BC: Douglas and McIntyre (2021), 192 pp., h/bk, ISBN: 9-781-7716-2284-4, $44.95
Biosynthesis of silver nanoparticles using nanocurcumin extracted from fresh turmeric of Vietnam
Authors: Kim Anh Le Thi , Dai Vuong Le , Quoc Bao Vo-Van , Phuong Nga Nguyen Thi , Luan Le Van 
Published: August 2022

Abstract
This study presents a novel process to synthesize curcumin nanoparticles from fresh turmeric. An ultrasonic-assisted cajeput oil in water emulsion technique was used to synthesize nanocurcumin. The prepared nanocurcumin was spherical with an average size of 47 nm and size distribution of 5–80 nm. The synthesized nanocurcumin showed improved aqueous-phase solubility, and it was used as a reducing agent and stabilizer for biosynthesizing silver nanoparticles. Furthermore, the X-ray diffraction pattern of the silver nanoparticles showed four distinct diffraction peaks at 38.3°, 44.6°, 65.1°, and 78.1° corresponding to the lattice planes of face-centered cubic silver ((111), (200), (220), and (311)). Transmission electron microscopy analysis indicated the average size and maximum size distribution (80 %) of the silver nanoparticles were 10.9 nm and 5–15 nm, respectively. UV–visible spectroscopy measurement of samples indicated the localized surface plasmon resonance absorbance of an aqueous dispersion of silver nanoparticles at 406 nm. Zeta potential analysis revealed a negative charge with a magnitude of −27.2 mV, which indicated higher aqueous dispersion stability of the silver nanoparticles prepared from nanocurcumin. The nanoparticles showed antibacterial activity against Vibrio parahaemolyticus.
A new modified technique to study the dynamics of fractional hyperbolic-telegraph equations
Authors: Khan Hassan , Hajira  , Khan Qasim , Kumam Poom , Tchier Fairouz , Singh Gurpreet , Sitthithakerngkiet Kanokwan , Tawfiq Ferdous Mohammed 
Published: August 2022

AbstractUsually, to find the analytical and numerical solution of the boundary value problems of fractional partial differential equations is not an easy task; however, the researchers devoted their sincere attempt to find the solutions of various equations by using either analytical or numerical procedures. In this article, a very accurate and prominent method is developed to find the analytical solution of hyperbolic-telegraph equations with initial and boundary conditions within the Caputo operator, which has very simple calculations. This method is called a new technique of Adomian decomposition method. The obtained results are described by plots to confirm the accuracy of the suggested technique. Plots are drawn for both fractional and integer order solutions to confirm the accuracy and validity of the proposed method. Solutions are obtained at different fractional orders to discuss the useful dynamics of the targeted problems. Moreover, the suggested technique has provided the highest accuracy with a small number of calculations. The suggested technique gives results in the form of a series of solutions with easily computable and convergent components. The method is simple and straightforward and therefore preferred for the solutions of other problems with both initial and boundary conditions.
Knowledge in action: what the feet can learn to know
Authors: Pettinen Katja 
Published: August 2022

AbstractThis article deploys Peircean approach to bodily skills, foregrounding motricity as a semiotically mediated and a “suprasubjective” process. By examining two contrasting skills – javelin and martial arts – I draw out the relevance of dynamic movement to the semiotics of sport and embodiment. These contrasting movements expose different epistemological assumptions since they emerge in distinct cultural traditions. To attend to the cultural dimension of movement practices – including the mediation of signs making certain movement forms seem reasonable or desirable in the first place – I highlight ecological dimensions of each somatic tradition. This ecological focus aligns with Peirce’s project of tracking how semiotic signs are positioned and mediated. To make ecological factors of motricity more recognizable, I contrast somatic engagements that take place on synthetic, predictable substrates and somatic engagements that take place on variable, unpredictable ground. In a similar way to the classic gestalt figure-ground relations, where perception of a figure depends on the particulars of the ground, I suggest that the ground upon which somatic action occurs shapes the way we make sense of it epistemologically. These different grounds – both literally and figuratively – operate representationally via thirdness: they lead us to conceptualize movement in culturally and historically particular ways.
Fencing blindfolded: extending meaning through sound, floor, and blade
Authors: Koncul Ana 
Published: August 2022

Abstract
Fencing for the blind and visually impaired is an emerging sub-discipline of fencing that creates unusual conditions for meaning-making through interaction between embodied endowments and worldly affordances. With the rules of fencing slightly adjusted to the needs of the blindfolded participants – regardless of their sightedness – the discipline requires the fencers to engage in a duel by relying on other than visual cues. This article explores what an autoethnographic account of experiences of participation in fencing for the blind and visually impaired brings to debates on the embodied, and specifically sensory difference. The discussion of these experiences intersects with debates on affect, affordance, and habit, with all three having important roles in related semiotic processes. Presented vignettes draw upon the author’s lived experiences of participation in fencing for the blind and visually impaired and are analyzed as part of a mixed-method autoethnographic study, accompanied by sensory methodologies, with a focus on an inquiry beyond the visual. The vignettes elucidate how we make sense of our surroundings through a complex engagement with the ecology of sensory and affective processes. In addition to exploring the role of affective and pre-conceptual aspects of our experiences, the article seeks to understand how semiosis occurs through both exposure to as well as the active pursuit of specific environmental signs available to us. The article also derives from biosemiotics to examine the complex relationship between meaning-making processes and habits. Finally, the autoethnographic account provides an insight into how we habituate the world and our embodied differences and thus enable meaning-making processes.