bluuebunny/crossref_metadata_2025_split huggingface dataset:
Valence bond glass state in the 4d1 fcc antiferromagnet Ba2LuMoO6
Authors: Mustonen O. H. J. , Mutch H. M. , Walker H. C. , Baker P. J. , Coomer F. C. , Perry R. S. , Pughe C. , Stenning G. B. G. , Liu C. , Dutton S. E. , Cussen E. J. 
Published: July 2022

AbstractB-site ordered 4d1 and 5d1 double perovskites have a number of potential exotic ground states including multipolar order, quantum spin liquids and valence bond glass states. These arise from the complex interactions of spin-orbital entangled Jeff = 3/2 pseudospins on the geometrically frustrated fcc lattice. The 4d1 Mo5+ perovskite Ba2YMoO6 has been suggested to have a valence bond glass ground state. Here we report on the low temperature properties of powder samples of isostructural Ba2LuMoO6: the only other known cubic 4d1 perovskite with one magnetic cation. Our muon spectroscopy experiments show that magnetism in this material remains dynamic down to 60 mK without any spin freezing or magnetic order. A singlet-triplet excitation with a gap of Δ = 28 meV is observed in inelastic neutron scattering. These results are interpreted as a disordered valence bond glass ground state similar to Ba2YMoO6. Our results highlight the differences of the 4d1 double perovskites in comparison to cubic 5d1 analogues, which have both magnetic and multipolar order.
Ribonucleotide reductase M2B in the myofibers modulates stem cell fate in skeletal muscle
Authors: Chen Wan-Jing , Lin I-Hsuan , Lee Chien-Wei , Yoshioka Kiyoshi , Ono Yusuke , Yan Yu-Ting , Yen Yun , Chen Yi-Fan 
Published: July 2022

AbstractThe balance among quiescence, differentiation, and self-renewal of skeletal muscle stem cells (MuSCs) is tightly regulated by their intrinsic and extrinsic properties from the niche. How the niche controls MuSC fate remains unclear. Ribonucleotide reductase M2B (Rrm2b) modulates MuSC quiescence/differentiation in muscle in response to injury. Rrm2b knockout in myofibers, but not in MuSCs, led to weakness of muscles, such as a loss of muscle mass and strength. After muscle injury, damaged myofibers were more efficiently repaired in the Rrm2b myofiber-specific knockout mice than the control mice, but these myofibers were thinner and showed weak functioning. Rrm2b-deleted myofibers released several myokines, which trigger MuSCs to differentiate but not re-enter the quiescent stage to replenish the stem cell pool. Overall, Rrm2b in the myofibers plays a critical role in modulating the MuSC fate by modifying the microenvironment, and it may lead to a possible strategy to treat muscle disorders.
The University of Pennsylvania glioblastoma (UPenn-GBM) cohort: advanced MRI, clinical, genomics, & radiomics
Authors: Bakas Spyridon , Sako Chiharu , Akbari Hamed , Bilello Michel , Sotiras Aristeidis , Shukla Gaurav , Rudie Jeffrey D. , Santamaría Natali Flores , Kazerooni Anahita Fathi , Pati Sarthak , Rathore Saima , Mamourian Elizabeth , Ha Sung Min , Parker William , Doshi Jimit , Baid Ujjwal , Bergman Mark , Binder Zev A. , Verma Ragini , Lustig Robert A. , Desai Arati S. , Bagley Stephen J. , Mourelatos Zissimos , Morrissette Jennifer , Watt Christopher D. , Brem Steven , Wolf Ronald L. , Melhem Elias R. , Nasrallah MacLean P. , Mohan Suyash , O’Rourke Donald M. , Davatzikos Christos 
Published: July 2022

AbstractGlioblastoma is the most common aggressive adult brain tumor. Numerous studies have reported results from either private institutional data or publicly available datasets. However, current public datasets are limited in terms of: a) number of subjects, b) lack of consistent acquisition protocol, c) data quality, or d) accompanying clinical, demographic, and molecular information. Toward alleviating these limitations, we contribute the “University of Pennsylvania Glioblastoma Imaging, Genomics, and Radiomics” (UPenn-GBM) dataset, which describes the currently largest publicly available comprehensive collection of 630 patients diagnosed withde novoglioblastoma. The UPenn-GBM dataset includes (a) advanced multi-parametric magnetic resonance imaging scans acquired during routine clinical practice, at the University of Pennsylvania Health System, (b) accompanying clinical, demographic, and molecular information, (d) perfusion and diffusion derivative volumes, (e) computationally-derived and manually-revised expert annotations of tumor sub-regions, as well as (f) quantitative imaging (also known as radiomic) features corresponding to each of these regions. This collection describes our contribution towards repeatable, reproducible, and comparative quantitative studies leading to new predictive, prognostic, and diagnostic assessments.
Comparison of lactate/albumin ratio to lactate and lactate clearance for predicting outcomes in patients with septic shock admitted to intensive care unit: an observational study
Authors: Shadvar Kamran , Nader-Djalal Nader , Vahed Noushin , Sanaie Sarvin , Iranpour Afshin , Mahmoodpoor Ata , Vahedian-Azimi Amir , Samim Abbas , Rahimi-Bashar Farshid 
Published: July 2022

AbstractThe aim of this study was to evaluate the prognostic value of the Lactate to Albumin (L/A) ratio compared to that of lactate and lactate clearance in predicting outcomes in patients with septic shock. This was a multi-center observational study of adult patients with septic shock, who admitted to intensive care units (ICUs) at Shohada and Imam Reza Hospitals, Tabriz, Iran, between Sept 2018 and Jan 2021. The area under the curve (AUC) of receiver operating characteristic (ROC) curve and multivariate logistic regression analyses were used to explore associations of the L/A ratio, lactate and lactate clearance on the primary (mortality) and secondary outcomes [ICU length of stay (LOS), duration of mechanical ventilation (MV), need of renal replacement therapy (RRT) and duration of using vasopressors] at baseline, 6 h and 24 h of septic shock recognition. Best performing predictive value for mortality were related to lactate clearance at 24 h, L/A ratio at 6 h and lactate levels at 24 h with (AUC 0.963, 95% CI 0.918–0.987, P < 0.001), (AUC 0.917, 95% CI 0.861–0.956, P < 0.001), and (AUC 0.904, 95% CI 0.845–0.946, P < 0.001), respectively. Generally, the lactate clearance at 24 h had better prognostic performance for mortality and duration of using vasopressor. However, the L/A ratio had better prognostic performance than serum lactate and lactate clearance for RRT, ICU LOS and MV duration.
Study on emergency escape route planning under fire accidents in the Burtai coal mine
Authors: Jinzhang Jia , Fengxiao Wang 
Published: July 2022

AbstractDeveloping an effective safety emergency plan for coal mines is crucial to prevent and reduce accidents, as well as improve the emergency response capability. This paper identifies and analyzes potential accident hazards in the Burtai coal mine through a comprehensive and practical investigation of risk factors. Based on a mathematical model of a mine fire disaster relief algorithm, the MATLAB software is used to conduct numerical simulations of the dynamic spreading process of the fire smoke. Several escape routes are determined based on the simulation results, including the main escape route at the working face of coal mining, the main escape route at the working face of tunneling, and the main escape route against the reverse wind in the main inclined shaft, the auxiliary adit, and the main air intake roadway. The results presented in this study can provide guidance for improving fire emergency escape and rescue plans of the Burtai coal mine.
Deep multi-modal learning for joint linear representation of nonlinear dynamical systems
Authors: Qian Shaodi , Chou Chun-An , Li Jr-Shin 
Published: July 2022

AbstractDynamical systems pervasively seen in most real-life applications are complex and behave by following certain evolution rules or dynamical patterns, which are linear, non-linear, or stochastic. The underlying dynamics (or evolution rule) of such complex systems, if found, can be used for understanding the system behavior, and furthermore for system prediction and control. It is common to analyze the system’s dynamics through observations in different modality approaches. For instance, to recognize patient deterioration in acute care, it usually relies on monitoring and analyzing vital signs and other observations, such as blood pressure, heart rate, respiration, and electroencephalography. These observations convey the information describing the same target system, but the dynamics is not able to be directly characterized due to high complexity of individual modality and maybe time-delay interactions among modalities. In this work, we suppose that the state behavior of a dynamical system follows an intrinsic dynamics shared among these modalities. We specifically propose a new deep auto-encoder framework using the Koopman operator theory to derive the joint linear dynamics for a target system in a space spanned by the intrinsic coordinates. The proposed method aims to reconstruct the original system states by learning the information provided among multiple modalities. Furthermore, with the derived intrinsic dynamics, our method is capable of restoring the missing observations within and across modalities, and used for predicting the future states of the system that follows the same evolution rule.
Influence of concomitant percutaneous transluminal angioplasty with percutaneous coronary intervention on clinical outcomes of stable lower extremity artery diseases
Authors: Lee Yonggu , Kim Byung-Sik , Shin Jeong-Hun , Kim Woohyeun , Kook Hyungdon , Park Hwan-Cheol , Park Minae , Park Sojeong , Lim Young-Hyo 
Published: July 2022

AbstractConcomitant percutaneous transluminal angioplasty (PTA) at the time of percutaneous coronary intervention (PCI) is often performed because lower extremity artery disease (LEAD) commonly coincides with coronary artery disease. We investigated the impact of concomitant PTA on both cardiovascular and limb outcomes in the Korean National Health Insurance Service registry. Among 78,185 patients undergoing PCI, 6563 patients with stable LEAD without limb ischemia were included. After 1:5 propensity score matching was conducted, 279 patients in the PTA + PCI group and 1385 patients in the PCI group were compared. Multivariate Cox proportional hazard models showed that the risk of all-cause death was higher in the PTA + PCI group than in the PCI group, whereas the risks of myocardial infarction, repeat revascularization, stroke, cardiovascular death and bleeding events were not different between the 2 groups. In contrast, the risks of end-stage renal disease and unfavorable limb outcomes were higher in the PTA + PCI group. Mediation analyses revealed that amputation and PTA after discharge significantly mediated the association between concomitant PTA and all-cause death. Concomitant PTA was not associated with an increased risk of cardiovascular events but may increase the risk of all-cause death mediated by unfavorable renal and limb outcomes in patients with stable LEAD.
R-spondin3 is a myokine that differentiates myoblasts to type I fibres
Authors: Mita Yoshitaka , Zhu Haonan , Furuichi Yasuro , Hamaguchi Hiroki , Manabe Yasuko , Fujii Nobuharu L. 
Published: July 2022

AbstractMuscle fibres are broadly categorised into types I and II; the fibre-type ratio determines the contractile and metabolic properties of skeletal muscle tissue. The maintenance of type I fibres is essential for the prevention of obesity and the treatment of muscle atrophy caused by type 2 diabetes or unloading. Some reports suggest that myokines are related to muscle fibre type determination. We thus explored whether a myokine determines whether satellite cells differentiate to type I fibres. By examining the fibre types separately, we identified R-spondin 3 (Rspo3) as a myokine of interest, a secreted protein known as an activator of Wnt signalling pathways. To examine whether Rspo3 induces type I fibres, primary myoblasts prepared from mouse soleus muscles were exposed to a differentiation medium containing the mouse recombinant Rspo3 protein. Expression of myosin heavy chain (MyHC) I, a marker of type I fibre, significantly increased in the differentiated myotubes compared with a control. The Wnt/β-catenin pathway was shown to be the dominant signalling pathway which induces Rspo3-induced MyHC I expression. These results revealed Rspo3 as a myokine that determines whether satellite cells differentiate to type I fibres.
A 19 day earth tide measurement with a MEMS gravimeter
Authors: Prasad Abhinav , Middlemiss Richard P. , Noack Andreas , Anastasiou Kristian , Bramsiepe Steven G. , Toland Karl , Utting Phoebe R. , Paul Douglas J. , Hammond Giles D. 
Published: July 2022

AbstractThe measurement of tiny variations in local gravity enables the observation of subterranean features. Gravimeters have historically been extremely expensive instruments, but usable gravity measurements have recently been conducted using MEMS (microelectromechanical systems) sensors. Such sensors are cheap to produce, since they rely on the same fabrication techniques used to produce mobile phone accelerometers. A significant challenge in the development of MEMS gravimeters is maintaining stability over long time periods, which is essential for long term monitoring applications. A standard way to demonstrate gravimeter stability and sensitivity is to measure the periodic elastic distortion of the Earth due to tidal forces—the Earth tides. Here, a 19 day measurement of the Earth tides, with a correlation coefficient to the theoretical signal of 0.975, has been presented. This result demonstrates that this MEMS gravimeter is capable of conducting long-term time-lapse gravimetry, a functionality essential for applications such as volcanology.
Improvement of energy conservation using blockchain-enabled cognitive wireless networks for smart cities
Authors: Rani Shalli , Babbar Himanshi , Shah Syed Hassan Ahmed , Singh Aman 
Published: July 2022

AbstractIn Smart Cities’ applications, Multi-node cooperative spectrum sensing (CSS) can boost spectrum sensing efficiency in cognitive wireless networks (CWN), although there is a non-linear interaction among number of nodes and sensing efficiency. Cooperative sensing by nodes with low computational cost is not favorable to improving sensing reliability and diminishes spectrum sensing energy efficiency, which poses obstacles to the regular operation of CWN. To enhance the evaluation and interpretation of nodes and resolves the difficulty of sensor selection in cognitive sensor networks for energy-efficient spectrum sensing. We examined reducing energy usage in smart cities while substantially boosting spectrum detecting accuracy. In optimizing energy effectiveness in spectrum sensing while minimizing complexity, we use the energy detection for spectrum sensing and describe the challenge of sensor selection. This article proposed the algorithm for choosing the sensing nodes while reducing the energy utilization and improving the sensing efficiency. All the information regarding nodes is saved in the fusion center (FC) through which blockchain encrypts the information of nodes ensuring that a node’s trust value conforms to its own without any ambiguity, CWN-FC pick high-performance nodes to engage in CSS. The performance evaluation and computation results shows the comparison between various algorithms with the proposed approach which achieves 10% sensing efficiency in finding the solution for identification and triggering possibilities with the value of $$\alpha = 1.5$$

α
=
1.5

and $$\gamma = 2.5$$

γ
=
2.5

with the varying number of nodes.
Evaluation of the microbial reduction efficacy and perception of use of an ozonized water spray disinfection technology
Authors: Mascarenhas Luis Alberto Brêda , dos Santos Laerte Marlon Conceição , Oliveira Fabricia Oliveira , Rodrigues Leticia de Alencar Pereira , Neves Paulo Roberto Freitas , Moreira Greta Almeida Fernandes , Santos Alex Alisson Bandeira , Lobato Gabriela Monteiro , Nascimento Carlos , Gerhardt Marcelo , Machado Bruna Aparecida Souza 
Published: July 2022

AbstractThe development of new approaches for the decontamination of surfaces is important to deal with the processes related to exposure to contaminated surfaces. Therefore, was evaluated the efficacy of a disinfection technology using ozonized water (0.7–0.9 ppm of O3) on the surfaces of garments and accessories of volunteers, aiming to reduce the spread of microbial pathogens in the workplace and community. A Log10 microbial reduction of 1.72–2.40 was observed between the surfaces tested. The microbial reductions remained above 60% on most surfaces, and this indicated that the disinfection technology was effective in microbial log reduction regardless of the type of transport used by the volunteers and/or their respective work activities. In association with the evaluation of efficacy, the analysis of the perception of use (approval percentage of 92.45%) was fundamental to consider this technology as an alternative for use as a protective barrier, in conjunction with other preventive measures against microbiological infections, allowing us to contribute to the availability of proven effective devices against the spread of infectious agents in the environment.
Molecular dynamics simulations explore effects of electric field orientations on spike proteins of SARS-CoV-2 virions
Authors: Kuang Zhifeng , Luginsland John , Thomas Robert J. , Dennis Patrick B. , Kelley-Loughnane Nancy , Roach William P. , Naik Rajesh R. 
Published: July 2022

AbstractEmergence of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its current worldwide spread have caused a pandemic of acute respiratory disease COVID-19. The virus can result in mild to severe, and even to fatal respiratory illness in humans, threatening human health and public safety. The spike (S) protein on the surface of viral membrane is responsible for viral entry into host cells. The discovery of methods to inactivate the entry of SARS-CoV-2 through disruption of the S protein binding to its cognate receptor on the host cell is an active research area. To explore other prevention strategies against the quick spread of the virus and its mutants, non-equilibrium molecular dynamics simulations have been employed to explore the possibility of manipulating the structure–activity of the SARS-CoV-2 spike glycoprotein by applying electric fields (EFs) in both the protein axial directions and in the direction perpendicular to the protein axis. We have found out the application of EFs perpendicular to the protein axis is most effective in denaturing the HR2 domain which plays critical role in viral-host membrane fusion. This finding suggests that varying irradiation angles may be an important consideration in developing EF based non-invasive technologies to inactivate the virus.
Home-cage behavior in the Stargazer mutant mouse
Authors: Schirmer Catharina , Abboud Mark A. , Lee Samuel C. , Bass John S. , Mazumder Arindam G. , Kamen Jessica L. , Krishnan Vaishnav 
Published: July 2022

AbstractIn many childhood-onset genetic epilepsies, seizures are accompanied by neurobehavioral impairments and motor disability. In the Stargazer mutant mouse, genetic disruptions of Cacng2 result in absence-like spike-wave seizures, cerebellar gait ataxia and vestibular dysfunction, which limit traditional approaches to behavioral phenotyping. Here, we combine videotracking and instrumented home-cage monitoring to resolve the neurobehavioral facets of the murine Stargazer syndrome. We find that despite their gait ataxia, stargazer mutants display horizontal hyperactivity and variable rates of repetitive circling behavior. While feeding rhythms, circadian or ultradian oscillations in activity are unchanged, mutants exhibit fragmented bouts of behaviorally defined “sleep”, atypical licking dynamics and lowered sucrose preference. Mutants also display an attenuated response to visual and auditory home-cage perturbations, together with profound reductions in voluntary wheel-running. Our results reveal that the seizures and ataxia of Stargazer mutants occur in the context of a more pervasive behavioral syndrome with elements of encephalopathy, repetitive behavior and anhedonia. These findings expand our understanding of the function of Cacng2.
The adverse impact of herbicide Roundup Ultra Plus in human spermatozoa plasma membrane is caused by its surfactant
Authors: Torres-Badia Mercedes , Solar-Malaga Soraya , Serrano Rebeca , Garcia-Marin Luis J. , Bragado M. Julia 
Published: July 2022

AbstractThe scarce research about the worldwide used glyphosate-based herbicide Roundup is controversial in human reproduction, especially spermatozoa. This study investigates the in vitro effect in human spermatozoa of Roundup Ultra Plus (RUP), its active ingredient glyphosate and its non-active, surfactant. Human spermatozoa were incubated (1 h, 37 °C) in presence/absence of RUP 0.01%, glyphosate, or equivalent surfactant concentration. Motility and sperm parameters were analyzed by C.A.S.A and flow cytometry, respectively. RUP significantly increases sperm plasma membrane lipid disorganization in a concentration-dependent manner while it decreases plasma membrane integrity. RUP significantly increases the death spermatozoa population after A23187-induced acrosome reaction, without affecting sperm viability, mitochondrial membrane potential, ROS content, acrosome membrane damage, phosphatidylserine exposure, A23187-induced acrosome reaction or GSK3 phosphorylation. RUP also significantly decreases motile and the a + b sperm populations. Interestingly, all sperm effects caused by RUP 0.01% are mimicked by its surfactant POEA at equivalent concentration. However, glyphosate does not affect any sperm parameter, even using 10-times higher concentration than the RUP 0.01% equivalent. RUP disturbs lipid organization and integrity of human sperm plasma membrane and reduces motility, without affecting viability or functional parameters. Importantly, RUP adverse effects in human spermatozoa are caused by the surfactant and no by glyphosate.
The relationship between serum sex hormone and cardiac echocardiographic findings in healthy men
Authors: Yeo Yohwan , Park Seung Woo , Lee Sang-Chol , Song Yun-Mi 
Published: July 2022

AbstractSerum sex hormones are known to be associated with cardiovascular disease (CVD), but effects in healthy men on cardiac function have not been well quantified. The authors sought to evaluate an association of sex hormones with cardiac structure and function. Study participants were 857 Korean men without significant cardiovascular diseases participating in the Healthy Twin Study. We estimated the associations of total testosterone (TT) and sex hormone-binding globulin (SHBG) with cardiac structure and function measured by echocardiography using a linear mixed regression model with consideration of random and fixed effects of covariates. The ratio of peak early diastolic velocity of mitral inflow over peak early diastolic mitral annular velocity (E/e’) and left atrial volume index (LAVI), functional parameters reflecting left ventricle (LV) filling pressure, were inversely associated with TT even after further cross-adjustment for SHBG level. There was a positive association between LAVI and SHBG, regardless of TT adjustment. These findings suggest that serum testosterone level is positively associated with LV diastolic function independent of SHBG level.