bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prediction model for missed abortion of patients treated with IVF-ET based on XGBoost: establishment and evaluation
Authors: Yuan Guanghui , Lv Bohan , Du Xin , Zhang Huimin , Zhao Mingzi , Liu Yingxue , Hao Cuifang 
Published: May 2022

Abstract
Aim: To establish a model based on XGBoost to predict the risk of missed abortion in patients treated with in vitro fertilization-embryo transfer (IVF-ET), evaluate its prediction ability, and compare with the traditional logical regression model.Methods: The clinical data of 1017 infertile women treated with IVF-ET were collected retrospectively. The independent risk factors were screened by Univariate analysis and binary logistic regression analysis, and then all cases were randomly divided into training set and test set according to the proportion of 7:3 for model construction and verification evaluation. The prediction models are constructed by traditional logical regression method and XGBoost method respectively, and then the prediction performance of the two models is tested by resampling.Results: Binary logistic regression analysis showed that female age, male age, abnormal ovarian structure, prolactin (PRL), anti-Müllerian hormone (AMH), activated partial thromboplastin time (APTT), anti cardiolipin antibody (ACA) and thyroid peroxidase antibody (TPO-Ab) were the factors that independently influenced missed abortion (P<0.05). The AUC score and F1 score with the training set of XGBoost model were 0.877±0.014 and 0.730±0.019. They were significantly higher than those of logistic model (0.713±0.013 and 0.568±0.026). In the evaluation of the test set, the AUC score and F1 score of XGBoost model were 0.759±0.023 and 0.566±0.042. They were also higher than those of logistic model (0.695±0.030 and 0.550±049).Conclusions: We established a prediction model based on XGBoost algorithm, which can accurately predict the risk of missed abortion in patients with IVF-ET. The performance of this model is better than the traditional logical regression model.
Gender-related factors associated with delayed diagnosis of Tuberculosis in Eastern Europe and Central Asia
Authors: Turusbekova Nonna , Celan Cristina , Caraulan Liliana , Rucsineanu Oxana , Jibuti Mariam , Ibragimova Oxana , Saidova Nargis 
Published: May 2022

Abstract
Tuberculosis (TB), a preventable and treatable disease, yearly affects millions of people and takes more than a million lives. Recognizing the symptoms and obtaining the correct diagnosis are vital steps towards treatment and cure. How timely a person with TB gets diagnosed may be influenced by biological differences between the sexes, and factors that are linked to the person’s gender, in the context of the prevailing gender norms. According to our hypothesis, gender-related factors contribute to delays in the diagnosis of TB. We investigated four countries (Georgia, Kazakhstan, Republic of Moldova, and Tajikistan) of Eastern Europe and Central Asia (EECA) - a region with a high burden of drug-resistant TB, scarcity of gender-related TB information, and varying gender equality. Retrospective information was collected through desk reviews, and directly from the people with a history of TB - through in-depth interviews and focus group discussions. We did not find differences between genders in the way participants recognized TB symptoms. In three countries women de-prioritized seeking diagnosis because of their lack of access to finances, and household-related obligations. In all four countries, men, traditionally carrying the weight of economically supporting the family, tended to postpone TB diagnosis. In two countries women experienced stigma more often than men, and it was a deterrent factor to seeking healthcare. The role of gender in obtaining the correct diagnosis came forth only among the respondents from Georgia and to some extent from Kazakhstan. We conclude that there are barriers to health care seeking and TB diagnosis that affect differently women, men and gender-diverse persons in EECA region.
Thermal and Mechanical Investigations of (Bi,Pb)-2212 superconductor added with different oxide nanoparticles
Authors: Matar M. , Basma H. , Abbas S. , Awad R. 
Published: May 2022

Abstract

In this study, superconducting samples of type Bi1.6Pb0.4Sr1.9Ca1.1Cu2.1Oy,(Bi, Pb))-2212, added with CdO, CdMnO, and CdFeO nanoparticles, were synthesized using a solid state reaction technique. The samples were examined using X-ray powder diffraction (XRD) and scanning electron microscopy (SEM). Thermogravimetric analysis (TGA) was utilized to evaluate the thermal stability of the pure sample throughout the different stages of the phase formation and the effect of the nanoparticles addition. The weight loss/gain by the three additions is related to the excess of oxygen, confirmed via Iodometric titration analysis and from the findings of oxygen diffusion energy using TGA data. Vickers microhardness measurements were conducted at various applied loads (0.49–9.8 N). All of the prepared samples displayed a typical 'indentation size effect' (ISE) behavior based on the HV measurements. It was found that the optimum addition of nanoparticles, for increasing the microhardness of the (Bi, Pb)-2212 phase, was at x = 0.05 wt. %. Furthermore, various mechanical properties as Elastic modulus (E), yield strength (Y), fracture toughness(K), and brittleness index (B) were calculated for three additions of the samples studied. As for the theoretical examination of HV in the saturation limit regions, the indentation-induced cracking (IIC) model wins the comparison.
Preparation of PET/PDMS/Collagen nanofibrous membrane embedded in a microfluidic device for cell culture
Authors: Eslam Houra Mobaleghol , Tabatabaei Seyed Nasrollah , Fayazbakhsh Farzaneh , Salami Seyed Alireza , Ghanbari Hossein 
Published: May 2022

Abstract
Electrospun nanofibers can be used as membranes for cell culture applications. In addition to their high performance and cost-effectiveness, nanofibers can be made from a variety of polymers where that can be utilized in microfluidic devices as separators, filters, and for biological assessments. In this paper, we have employed a two-pump technique to prepare a hybrid nanofiber-based membrane with a biocompatible polyethylene terephthalate (PET), polydimethylsiloxane (PDMS), and collagen. The introduction of collagen creates a suitable substrate for cell attachment and decreased hydrophobicity. To sustain collagen on the fibers, the membranes were treated with glutaraldehyde vapor and then detoxified. The membrane integrity and structure were evaluated using SEM, AFM, FTIR, BET, and tensile apparatus. In addition, cell attachment capabilities and cytocompatibility were examined using SEM and Alamar Blue, respectively. The membrane was cased in a PDMS-based microfluidic device consisting of upper and lower channels. Our findings suggest that the incorporation of PET and PDMS indeed presents a superior bonding capability and prevents unwanted leakage. Then, Human Umbilical Vein Endothelial Cells (HUVECs) were cultured on the proposed membrane inside the upper channel of the device. To simulate the dynamic environment and induce cellular shear stress, the culture medium was flown through the channel and the conditions were kept overnight inside an incubator. Cellular staining by DAPI and further evaluation of cellular adhesion suggest that cells were well attached and viable inside the microfluidic device. The proposed membrane can be employed in fabrication of various biological barriers on-a-chip for the purpose of screening drugs, examining the effects of nanomaterials, and creation of in-vitro disease models.
A systematic review of the factors significantly influencing the quality of life of living liver donors
Authors: Shi Yuexian , Fan Yaru , Zhang Haiming , Cheng Mei , Zhu Zhi-Jun 
Published: May 2022

Abstract
Background Several reviews have summarized data on the medical outcomes and psychosocial status of living liver donors. However, a systematic review or synthesis of evidence on factors significantly influencing quality of life in living liver donors has not been conducted. With this systematic review, we aimed to synthesize the literature on predictors of or factors influencing quality of life in living liver donors post donation.Methods PubMed, Embase, CINHAL with full text, Web of Science and ProQuest Dissertations & Theses databases were searched for studies. The methodological quality of the individual studies was examined using a modified version of the National Institutes of Health Quality Assessment Tool. Factors influencing the four quality of life dimensions of physical functioning, psychological state, and social function and environment were extracted.Results The search yielded 6576 records, and a total of 16 articles (11 studies) were included in the systematic review. Four types of independent influencing factors, sociodemographic, donation-related, health-related, and psychosocial, were extracted from the included studies. Old age, recipient death, recent donation, postoperative complications experienced by donors, and donor concerns about their own well-being were consistently identified by several studies as negative influencing factors on physical function. Female donor, low education levels, longer hospital stay and/or more hospital visits due to donation, poor recipient outcome, recent donation, predonation concerns regarding their own well-being, and first-degree relative and spouse/partner donors were reported in several studies as negative predictors for psychological status. Factors affecting social function were considered by only two included articles.Conclusions The significant influencing factors summarized in our study provided convenient information for clinical practitioners to formulate precise interventions. Donors with these risk factors can be regarded as a vulnerable group and targeted interventions should be carried out to minimize possible negative effects.
Interplay of temperature and magnetic field on nonequilibrium transport in a correlated polar single molecular transistor with dissipation
Authors: Bhattacharyya Kuntal , Kalla Manasa , Chatterjee Ashok 
Published: May 2022

Abstract
Quantum magneto-transport in a dissipative single molecular transistor is investigated at finite temperature in the presence of electron correlation and electron-phonon interaction within the framework of the Anderson-Holstein-Caldeira-Leggett Hamiltonian. The electron-phonon interaction and dissipation are dealt with by canonical transformations and the Coulomb correlation is treated at the mean-field level. The transport properties such as spectral function, tunneling current, differential conductance and spin polarization are determined using the Keldysh method.
Comparison of the Predictive Accuracy of Intraocular lens Power Calculation After Phototherapeutic Keratectomy in Granular Corneal Dystrophy Type 2
Authors: Yoon Sook Hyun , Jo Woo Kyung , Kim Tae-im , Seo Kyoung Yul , Choi Jinseok , Jun Ikhyun , Kim Eung Kweon 
Published: May 2022

Abstract
Granular corneal dystrophy type 2 (GCD2) is an autosomal dominant disease affecting vision. Phototherapeutic keratectomy (PTK) is advantageous in removing vision-threatening corneal opacities and postponing keratoplasty; however, it potentially disturbs accurate intraocular lens (IOL) power calculation in cataract surgery. The myopic/hyperopic Haigis-L method with or without the central island has been reported; nevertheless, an optimal method has not yet been established. To compare the predictive accuracy of post-PTK IOL power calculations in GCD2, the retrospective data of thirty eyes from July 2017 to December 2020 were analyzed. All GCD2-affected eyes underwent post-PTK standard cataract surgery using the WaveLight EX500 platform (Alcon Laboratories, Inc., Fort Worth, TX) under a single surgeon. The mean prediction error (MPE) and absolute error (MAE) with the myopic/hyperopic Haigis-L and other formulas (Barrett Universal II, Barrett True-K, Haigis, SRK/T) by standard keratometry (K) and total kera-tometry (TK), where possible, were analyzed. Barrett Universal II and SRK/T were significantly superior to the myopic/hyperopic Haigis-L regarding the MPE and MAE. TK was not significantly superior to K in the same formula. In conclusion, this study suggests that the biometries and formulas, especially Barrett Universal II and SRK/T, are potentially useful in IOL power calculation in GCD2 after PTK.
Ginsenoside CK improves skeletal muscle insulin resistance by activating DRP1/PINK1-mediated mitophagy
Authors: Li Weili , Li Haiyang , Zheng Lujuan , Xia Jing , Yang Xiaoxuan , Yuan Ye , Fan Yuying 
Published: May 2022

Abstract
(1) Background: Skeletal muscle insulin resistance is the main cause of type 2 diabetes, in which mitochondrial homeostasis plays a key role. Ginsenoside CK is the main active compound of Panax ginseng C.A. Meyer with a variety of therapeutic effects, but there are few studies on its effect and mechanism on skeletal muscle insulin resistance; (2) Methods: qRT-PCR, Western blotting and Seahorse XFp cellular metabolism were used to detect the effects of CK on mitochondrial quality and function in skeletal muscle tissue and C2C12 cells. The insulin sensitivity was examined by immunofluorescence, 2-NBDG uptake and glycogen content detection. Mitochondrial morphology was observed by MitoTracker staining and transmission electron microscopy, and mitochondrial membrane potential (ΔΨm) was measured by JC-1. Finally, co-localization and siRNA targeting were used to illustrate the mechanisms of CK-induced mitophagy. (3) Results: We found that CK alleviates skeletal muscle insulin resistance by improving mitochondrial fusion/fission dynamic balance and mitochondrial fatty acid oxidation capacity in db/db mice. In fatty acid (FA)-induced insulin resistant C2C12 cell, CK promoted the translocation of GLUT4 to the cell membrane to improve glucose uptake and glycogen synthesis, and also improved the mitochondrial quality of C2C12 cells. CK improved the damaged ΔΨm, which was based on mitophagy activation. After knockdown of mitophagy-related receptors, the results revealed that DRP1/PINK1 was the key pathway of CK-induced mitophagy. (4) Conclusions: Ginsenoside CK activates skeletal muscle mitophagy via DRP1/PINK1 pathway to maintain mitochondria quality and function, and thereby alleviating insulin resistance in diabetic mice. These results indicate that ginsenoside CK is a promising lead compound against diabetes.
Impact of the Covid-19 pandemic on the care of rare and undiagnosed diseases patients in France: a longitudinal population-based study
Authors: Soussand Louis , Kuchenbuch Mathieu , Messiaen Claude , Sandrin Arnaud , Jannot Anne-Sophie , Nabbout Rima 
Published: May 2022

Abstract
Background: Preliminary data suggest that COVID-19 pandemic has generated a switch from face-to-face to remote care for individuals with chronic diseases. However, few data are reported for rare and undiagnosed diseases (RUDs). We aimed to assess the impact of the COVID-19 pandemic on the activities of the French reference network for RUDs in 2020.Results: In this observational, cross-sectional study, we extracted and analyzed the data of the French national registry for RUDs collected between Jan 1, 2019 and Dec 31, 2020. We compared the annual longitudinal evolution of face-to-face and remote care activities between 2019 and 2020 focusing on adult and pediatric patients. Compared to 2019, 2020 was marked by a decrease in rare diseases (RD) care activities (-12%) which mostly occurred during the first lockdown (-45%) but did not catch up. This decrease mostly concerned face-to-face care activities albeit a third of this decrease was compensated by telehealth activities which was multiplied by 9 during the first lockdown but decreased afterwards as in person care resumed. Finally, the total number of patients receiving care was lower in 2020(-9%) with a drastic decrease of cases with newly confirmed diagnosis (-47%).Conclusion: Although telehealth was quickly introduced, RUD patient care was strongly affected by the COVID-19 pandemic in France with a decline in the number of patients treated and new patients included. This is likely to result in delays in patient diagnosis and care over the next few years.
Barriers and facilitators to physical activity in people with an inflammatory joint disease: A mixed methods study
Authors: Bell Kirsty , Conde Monserrat , Hendry Gordon , Rafferty Danny , Steultjens Martijn 
Published: May 2022

Abstract
Background
Physical activity has been shown to be of great benefit to people with an inflammatory joint disease (IJD), however people with an IJD have been shown to be very inactive compared to the general population. The aims of this study were to explore 1) whether the transition from a National Health Service (NHS)-run exercise programme into exercising in the community could be achieved successfully; and 2) the barriers and facilitators during the transition period.
Methods
This study adopted a complementary mixed-methods study design including a qualitative approach using focus groups and a prospective cohort study. Descriptive statistics were used to summarise the cohort study data. All variables were assessed for normality of distribution using the Sharpiro-Wilk test. Paired t-tests or Wilcoxon tests were undertaken for two consecutive assessment timepoints; one-way repeated measures ANOVAs or Friedman’s tests for three consecutive assessment timepoints. Micro-interlocutor analysis was used to analyse the focus group data. Areas of congruence and incongruence were explored by confirming the statistical results against the qualitative results. The adapted ecological model of the determinants of physical activity was then used as a framework to describe the findings.
Results
A successful transition was defined as still exercising in the community 6-months post discharge from the NHS-run Inflammatory Arthritis Exercise Programme. This was self-reported to be 90% of the cohort. An individual barrier to physical activity in people with an IJD was found to be the unpredictable nature of their condition. Other barriers and facilitators found were similar to those found in the general population such as recreation facilities, locations, transportation and cost. Other facilitators were similar to those found in people living with other chronic long-term conditions such as the importance of peer support.
Conclusions
90% of the cohort data were defined as a successful transition. People with an IJD have similar barriers and facilitators to exercise as the general population and those living with other chronic long-term conditions. A barrier which appears to be unique to this population group is that of the unpredictable nature of their condition which needs to be considered whenever tailoring any intervention.
The Radiographic Morphometry Of The Distal End Radius İn Anatolian Population
Authors: Nalbant¹ Asrın , İsmailoğlu² Eren , Turhan³ Ebru , Duygu Özden Bedre 
Published: May 2022

Abstract
Introduction: Distal radius fractures are arguably the most common orthopedic injuries encountered by orthopedic surgeons. Correction of dorsal tilt and radial height is essential to restore normal biomechanics of the wrist joint. This study aims to report the morphometry of the distal radius in the Anatolian population and compare it with similar studies in other races and humans.Methods: One hundred and twenty-four consecutive plain radiographs of the wrist joint were included. Radiographs that were not centered or rotated to the wrist joint were excluded from the study. Four radiological parameters were examined on all radiographs: radial height, radial tilt, ulnar variance, and palmar tilt. Only radiographs with fused physiques of the distal radius were considered.Results: Radial tilt angle was 23.35±1.96, palmar tilt angle was 15.7±, radial height (mm) was 10.55±4.34, ulnar variance (mm) was 0.32±1.79 (Table 1 ). When the data were compared with gender, only radial height values ​​showed a significant difference (p<0.001). The highest rate of negative ulnar variance was found (43.5%).Conclusion: Distal radius morphometry varies according to the patient's race, ethnicity, and structure. Comprehensive knowledge of the morphometry of the distal radius of the local population becomes critical for the treating surgeon. The results of this study can also be used as reference data for anatomical fit when treating DER injuries in the Anatolian population.
Understanding Pseudopapilledema on Spectral Domain Optical Coherence Tomography
Authors: Bassi Shikha , Pamu Ramesh , Varghese Anjaly 
Published: May 2022

Abstract
Objective: Optic nerve head drusen (ONHD), peripapillary hyperreflective ovoid mass like structures (PHOMS) and horizontal hyperreflective lines (HHL) are commonly seen in eyes with pseudopapilledema on spectral domain optical coherence tomography (SDOCT) .The objective of this study is to assess the frequency of ONHD, PHOMS and HHL on spectral domain OCT in the eyes diagnosed to have pseudopapilledema on clinical evaluation.Methods: Retrospective case control study of patients with pseudopapilledema and SD OCT imaging of the optic nerve head (n=48 eyes) and controls (n=20 eyes) .Volumetric OCT scans through the optic nerve head were studied to diagnose ONHD, HHL and PHOMS. The mean retinal nerve fiber layer thickness (RNFL) of eyes with ONHD was compared in eyes with deep drusens(DD) and both deep and superficial drusens(DSD). One proportion z test was used to find the difference in proportions.Results: 48 eyes of 27 subjects were studied. ONHD as described by the optic disc drusen study consortium was noted in 19 eyes (39.48%), p value-0.032 ,PHOMS in 31 eyes (64.6%),p value 0.043,HL in 19 eyes (39.48%) ,p value-0.032. Mean RNFL thickness were significantly lower in inferior and temporal quadrants in eyes with both DSD when compared to the eyes with DD only. (p value.008)Conclusions: PHOMS are more frequently seen than ONHD and HHL in eyes with pseudopapilledema. Absence of ONHD on SD OCT doesn’t preclude the diagnosis of pseudopapilledema.
Carbon-Oxygen Surface Formation Enhances Secondary Electron Yield in Cu, Ag and Au
Authors: Brown M. , Diaz L. , Aslan A. , Sanati M. , Portillo S. , Schamiloglu E. , Joshi R. P. 
Published: May 2022

Abstract
First-principles calculations coupled with Monte Carlo simulations are used to probe the role of a surface CO monolayer formation on secondary electron emission (SEE) from Cu, Ag, and Au (110) materials. It is shown that formation of such a layer increases both the secondary electron emission in all systems. Analysis of calculated total density of states (TDOS) in Cu, Ag, and Au, and partial density of states (PDOS) of C and O confirm the formation of a covalent type bonding between C and O atoms. It is shown that such a bond modifies the TDOS and extended it to lower energies, which is then responsible for an increase in the probability density of secondary electron generation. Furthermore, a reduction in inelastic mean free path is predicted for all systems. Our predicted results for the secondary electron yield (SEY) compare very favorably with experimental data in all three materials, and exhibit increases in SEY. This is seen to occur despite increases in the work function for Cu, Ag, and Au. The present analysis can be extended to other absorbates and gas atoms at the surface, and such analyses will be present elsewhere.