bluuebunny/crossref_metadata_2025_split huggingface dataset:
Brain‐derived neurotrophic factor overexpression in taste buds diminishes chemotherapy induced taste loss
Authors: Vukmanovic Nosrat Irina , Palacios Jerry L. , Kezian Steven , Luong Gloria , Tran Andrew , Vu Kim , Henson Bradley S. , Nosrat Philip , Lutfy Kabirullah , Nosrat Christopher A. 
Published: August 2022

AbstractVismodegib is used in patients suffering from advanced basal cell carcinoma (BCC), but 100% of the patients taking it report dysgeusia and 50% discontinue the treatment. Treatment with neurotrophic factors can stimulate neuronal survival and functional improvement in injured organs. Here, we analysed novel transgenic mouse lines in which brain‐derived neurotrophic factor (BDNF) is overexpressed in taste buds, to examine whether higher levels of BDNF would reduce or prevent negative side effects of vismodegib in the taste system. BDNF plays crucial roles for development, target innervation, and survival of gustatory neurons and taste buds. The behavioural test in this study showed that vehicle‐treated wild‐type mice prefered 10 mM sucrose over water, whereas vismodegib treatment in wild‐type mice caused total taste loss. Gustducin‐BDNF mice had a significantly increased preference for low concentration of sucrose solution over water compared to wild‐type mice, and most importantly the transgenic mice were able to detect low concentrations of sucrose following vismodegib treatment. We evaluated taste cell morphology, identity, innervation and proliferation using immunohistochemistry. All drug‐treated mice exhibited deficits, but because of a possible functional upcycled priming of the peripheral gustatory system, GB mice demonstrated better morphological preservation of the peripheral gustatory system. Our study indicates that overexpression of BDNF in taste buds plays a role in preventing degeneration of taste buds. Counteracting the negative side effects of vismodegib treatment might improve compliance and achieve better outcome in patients suffering from advanced BCC.
Anterior thalamic nuclei: A critical substrate for non‐spatial paired‐associate memory in rats
Authors: Hamilton Jennifer J. , Dalrymple‐Alford John C. 
Published: August 2022

AbstractInjury or dysfunction in the anterior thalamic nuclei (ATN) may be the key contributory factor in many instances of diencephalic amnesia. Experimental ATN lesions impair spatial memory and temporal discriminations, but there is only limited support for a more general role in non‐spatial memory. To extend evidence on the effects of ATN lesions, we examined the acquisition of biconditional associations between odour and object pairings presented in a runway, either with or without a temporal gap between these items. Intact adult male rats acquired both the no‐trace and 10‐s trace versions of this non‐spatial task. Intact rats trained in the trace version showed elevated Zif268 activation in the dorsal CA1 of the hippocampus, suggesting that the temporal component recruited additional neural processing. ATN lesions completely blocked acquisition on both versions of this association‐memory task. This deficit was not due to poor inhibition to non‐rewarded cues or impaired sensory processing, because rats with ATN lesions were unimpaired in the acquisition of simple odour discriminations and simple object discriminations using similar task demands in the same apparatus. This evidence challenges the view that impairments in arbitrary paired‐associate learning after ATN lesions require the use of multimodal spatial stimuli. It suggests that diencephalic amnesia associated with the ATN stems from degraded attention to stimulus–stimulus associations and their representation across a distributed memory system.
Method for statistical evaluation of cumulative damage models applied to block loading
Authors: Hectors Kris , Van Hecke Tanja , De Waele Wim 
Published: August 2022

AbstractThere is an abundance of nonlinear fatigue damage accumulation models but a lack of verification and comparison to experimental datasets. First, an extensive two‐level block loading experimental fatigue dataset is reprocessed according to current standard practice. Next, four nonlinear damage accumulation models and the Palmgren–Miner linear damage rule are critically compared using a range of statistical metrics. For the considered dataset, the Palmgren–Miner rule consistently performs worst and the damage curve approach is found to perform significantly better than the other nonlinear models. This study shows that the current practice of performance verification of new fatigue damage accumulation models in literature is too limited which enables cherry‐picking of verification datasets to improve perceived performance. Future fatigue damage accumulation models should be verified much more rigorously to both readily available and new experimental datasets.
Latrophilin‐3 heterozygous versus homozygous mutations in Sprague Dawley rats: Effects on egocentric and allocentric memory and locomotor activity
Authors: Regan Samantha L. , Sugimoto Chiho , Dawson Hannah E. , Williams Michael T. , Vorhees Charles V. 
Published: August 2022

AbstractLatrophilin‐3 (LPHN3) is a brain specific G‐protein coupled receptor associated with increased risk of attention deficit hyperactivity disorder (ADHD) and cognitive deficits. CRISPR/Cas9 was used to generate a constitutive knockout (KO) rat of Lphn3 by deleting exon 3, based on human data that LPHN3 variants are associated with some cases of ADHD. Lphn3 KO rats are hyperactive with an attenuated response to ADHD medication and have cognitive deficits. Here, we tested KO, heterozygous (HET), and wildtype (WT) rats to determine if there was a gene‐dosage effect. We tested the rats in home‐cage activity starting at postnatal day (P)35 and P50, followed by tests of egocentric learning (Cincinnati water maze [CWM]), spatial learning (Morris water maze [MWM]), working memory (radial water maze [RWM]), incidental learning (novel object recognition [NOR]), acoustic startle response (ASR) habituation, tactile startle response (TSR) habituation, prepulse modification of acoustic startle, shuttle‐box passive avoidance, conditioned freezing, and a mirror image version of the CWM. KO and HET rats were hyperactive. KO and HET rats had egocentric (CWM) and spatial deficits (MWM), increased startle response, and KO rats showed less conditioned freezing on contextual and cued memory; there were no effects on working memory (RWM) or passive avoidance. The selective gene‐dosage effect in Lphn3 HET rats indicates that Lphn3 exhibits dominate expression on functions where it is most abundantly expressed (striatum, hippocampus) but not on behaviors mediated by regions of low expression. The data add further evidence to the impact of this synaptic protein on brain function and behavior.
How do we feed grazing livestock in the future? A case for knowledge‐driven grazing systems
Authors: Horn Juliane , Isselstein Johannes 
Published: August 2022

AbstractGrassland degradation has been observed worldwide and is often a result of overexploitation or abandonment. Knowledge‐driven and precise grazing management is required to use grasslands' potential in a sustainable way. Information gaps lead to inefficiencies in grazing land management and ecosystem service provision. Rapid advances in automated sensors and information technologies for information acquisition on herbage availability, controlling animal grazing behaviour and setting up data‐driven decision support tools have the potential to improve grazing management. Sensors and IT‐based methods allow spatiotemporal dynamics in herbage mass and quality and sward structure and botanical composition to be obtained automatically. These monitoring methods enable a spatially and temporally precise adjustment of the forage allowance and stocking density. Virtual fencing (VF) is an innovative digital tool for fine‐tuned spatiotemporal control of grazing animals. VF enables farmers to adjust grazing flexibly and dynamically by moving the virtual borders on a mobile user interface and sending new coordinates to the GPS receiver unit on each animal's VF collar. VF promises high efficiency with no obvious negative impacts on animal welfare. The potential of VF is enormous, but its economic viability still needs to be verified and its acceptance by authorities and the public needs to be supported. A decision support system that optimizes grazing management and agronomic and ecological outcomes by integrating and analysing multiple data at high spatial and temporal resolution can provide sufficient knowledge and confidence in grazing management decisions. Integration of key technologies into a holistic concept can take grazing management to the next level.
Cold crystallization and morphology control of ZnO nanostructures for chemical sensors
Authors: Masuda Yoshitake 
Published: August 2022

AbstractCold crystallization and morphology control of ZnO nanostructures have been achieved. Various ZnO nanostructures, such as ZnO rod arrays, high c‐axis‐oriented stand‐alone ZnO self‐assembled films, ZnO particulate films, ZnO nanorod arrays, semicircular ZnO nanowhisker assemblies, bunched rose‐ and core–shell‐like ZnO particles, twin ZnO nanoarray assemblies, ZnO nanotubes, and ZnO nanoflowers, have been developed using the hexagonal crystal structure of ZnO. These structures have advantages, such as high anisotropy, high specific surface area, high crystallinity, and characteristic crystal facets, and can be applied in devices such as photoelectric conversion sensors, chemical sensors, gas sensors, batteries, and catalysts. Additionally, various nanostructures using other oxide materials are expected to be developed by applying the scientific knowledge obtained from the cold crystallization and morphology control of ZnO. Cold crystallization, which is a long‐standing challenge in the field of ceramics, has been realized, which is a historical turning point in the field of ceramics research.
Preparation and properties of ferrimagnetic glass–ceramic foams based on pyrite slag
Authors: Qu Xiaoyan , Liu Jianan , Zhang Meimei , Zhu Chaofeng , Zhao Yujun 
Published: August 2022

AbstractBy employing a melt‐sintering method, we prepared a new type of ferrimagnetic glass–ceramic foam (FGCF) using ferrimagnetic glass–ceramic and foaming agent SrCO3. The ferrimagnetic glass–ceramics were fabricated based on pyrite slag by a melt‐quenching method. The effects of foaming agent content, sintering temperature and time on microstructure, magnetic properties, microwave absorption performance, compressive strength, and thermal conductivity of the as‐obtained FGCF were analyzed. This foaming process at 1100°C for 40 min with 3‐wt% SrCO3 provided an FGCF with a bulk density of .693 g/cm3, a porosity of 63.60%, a specific saturation magnetic moment of 5.2 A m2/kg, a compressive strength of 2.61 MPa, a thermal conductivity of .241 W/(m K), and the calculated reflection loss of −12.1 dB for a layer thickness of 9 mm.
Effect of microwave‐assisted acid extraction on the physicochemical properties and structure of soy hull polysaccharides
Authors: Cai Wenqi , Zhang Hongyun , Chen XinRu , Yan Shiyu , Yang Lina , Song Hong , Li Jun , Liu Jun , Yu Hansong , Liu He , Zhu Danshi 
Published: August 2022

SummaryThis study aimed to investigate the effect of the extraction method on the physicochemical and structural properties of soy hull polysaccharide (SHP). Four types of SHP were extracted from soy hulls under the conditions of microwave‐assisted oxalic acid (or citric acid) extraction and hot water extraction: MOSP, MCSP, HOSP and HCSP. The results showed the polysaccharide extraction rate of MOSP, HOSP, MCSP and HCSP was 11.97%, 8.99%, 6.22% and 4.74% respectively. SHP is mainly composed of arabinose, galactose, mannose and galacturonic acid, and the relative molecular weight range was 104–106 Da. FT‐IR showed that SHP contained hydroxyl, amido, ester, carboxyl and ether bonds. The fingerprints of SHP showed that the main chain composition and molecular weight of the four SHPs were similar, and the main constituent unit was 1,4‐α‐D‐GalpA. In addition, the branched chains of polysaccharides contained 1,5‐α‐L‐arabinoside bond, β‐ 1,4‐mannoside bond and β‐1,4‐galactoside bond.
Left, right, left, right: 24–36‐months‐olds’ planning and execution of simple alternating actions
Authors: Schröer Lisanne , Cooper Richard P. , Mareschal Denis 
Published: August 2022

AbstractThis study investigated toddlers' ability to control simple alternating pattern actions, and how this relates to motor competence and executive functions. 70 toddlers between 24 and 36 months of age were instructed to sort coins in an alternating pattern into two boxes; left, right, left, right etc. Executive functions and memory competence performance were assessed in additional small games. The results showed that the ability to plan and execute actions according to a simple extended alternating pattern improved over toddlerhood. Furthermore, working memory and motor competence scores were both independent predictors of the ability to plan and execute simple alternating actions. These findings underscore the fact that between 24 and 36 months of age is a period in which the ability to string together multiple actions in a sequence to achieve a distal goal is still developing.
Changes in selective attention to articulating mouth across infancy: Sex differences and associations with language outcomes
Authors: Lozano Itziar , López Pérez David , Laudańska Zuzanna , Malinowska‐Korczak Anna , Szmytke Magdalena , Radkowska Alicja , Tomalski Przemysław 
Published: August 2022

AbstractInfants' attention to the mouth is thought to support language acquisition, yet this relation has been scantly tested longitudinally. This study assessed attention to the mouth and the eyes at 5.5 (n = 91; Polish, 49% females) and 11 months, between time‐point changes and their associations with language development in infancy (11 months) and toddlerhood (24 months). Sex differences were also explored. Results showed an age‐related increase in looking to the mouth, and the magnitude of this change was associated with productive language, but only in toddlerhood. By contrast, looking to the eyes did not change and its duration at 5.5 months correlated with language development at 2 years. Exploratory analyses showed that in females but not males, reduced mouth‐looking was related to better language outcomes in toddlerhood. Thus, looking to the mouth in infancy likely plays a long‐term role in language acquisition and is potentially modulated by participant sex.
Effecting change and improving practice in a regional Emergency Department: A Mental Health Nurse Practitioner's perspective
Authors: O'Sullivan Margaret 
Published: August 2022

Abstract
Providing appropriate, timely intervention and care to people who present with mental health issues to an Emergency Department presents unique ongoing challenges, often affecting patient experiences and outcomes. To address such concerns, a Mental Health Liaison Nurse role, led by a Mental Health Nurse Practitioner, was introduced to a regional Emergency Department. This role provided integrated emergency‐based mental health clinical practice, with positive findings reported in a recently published multi‐site translational research project. With sound quantitative and qualitative evidence detailing the benefits of this role, the experiential perspective from a clinician working in this frontline space further confirms the importance of having access to such a position in leading cultural and systemic change. This discussion article identifies key processes that align current research with the clinical perspective. Such processes recognize the challenges of implementing a new role and moving forward from these to embed consistent clinical practices. The need to build sound internal and external stakeholder partnerships, effect change implementation, and assign recommendations to ensure sustainability of improved practice and processes are highlighted in this paper. This article is, therefore, designed to assist other advanced practice nurses, who may be embarking on a similar journey and want to influence organizational policy and practice.
Relationship between items of DMIST and healing of diabetic foot ulcers
Authors: Tsuchiya Sayumi , Suriadi  , Sanada Hiromi , Sugama Junko , Oe Makoto 
Published: August 2022

AbstractA monitoring tool for the wound‐healing process of diabetic foot ulcers (DFUs) was developed. It comprises seven domains, namely, depth, maceration, inflammation/infection, size, tissue type of the wound bed, type of wound edge, and tunnelling/undermining. It was named “DMIST” based on the initials of its domains. Although DMIST is useful for assessing wound‐healing processes, the monitoring items related to wound healing remain unclear, thereby making the selection of optimal care based on the assessment difficult. We identified the relationship between the DMIST items and wound healing. This study was a secondary analysis of five previous investigations and was conducted using DMIST based on the diabetic foot ulcer assessment scale score and DFU images. Multivariate logistic regression was used to calculate odds ratios (ORs) and 95% confidence intervals (95% CIs) after simultaneously controlling for potential confounders. The examined DFU healing status revealed that some DFUs healed at 4 weeks from baseline, whereas some DFUs did not. Variables considered in the models were the scores of each DMIST domain. The study population comprised 146 Indonesian patients and 33 Japanese patients. Depth, maceration, and size were associated with DFU healing at 4 weeks from baseline [depth: OR = 0.317 (95% CI: 0.145‐0.693, P = 0.004); maceration: OR = 0.445 (95% CI: 0.221‐0.896, P = 0.023); size: OR = 0.623 (95% CI: 0.451‐0.862, P = 0.004)]. Our findings suggest that appropriate management of maceration promotes DFU healing.
The experiences of spousal and adult child caregivers of stroke survivors in transitional care: A qualitative systematic review
Authors: See Toh Wen Xiu Samantha , Lim Wei Heong Joshua , Yobas Piyanee , Lim Siriwan 
Published: August 2022

AbstractAimTo synthesize and present the currently available literature on the experiences of spousal and adult child caregivers of stroke patients in transitional care.DesignThis is a qualitative systematic review.Data SourcesEight electronic databases (PubMed, CINAHL, Cochrane, Embase, Web of Science, PsychINFO, ProQuest and Scopus) were searched from September 2020 to April 2022 for relevant literature and grey literature. Qualitative studies exploring the experiences of sspousal or adult child caregivers of stroke survivors up till 1 year after discharge were included.Review MethodsThe selection of articles was done by two independent reviewers who screened the titles and the abstracts of studies, and the full texts of selected articles. Quality appraisal and data extraction of selected articles were undertaken by two independent reviewers using Joanna Briggs Institute (JBI) critical appraisal tools. Data synthesis was conducted using a meta‐aggregative approach recommended by JBI.ResultsA total of 19 papers were included in this review. A total of three synthesized findings centred around caregivers' experience with healthcare professionals, changes in their life roles and needs, effects of caregiving and how they adapted to their changes were aggregated.ConclusionSpousal and adult child caregivers faced multiple barriers during transitional care, such as the lack of resources and an inability to cope with changes in their lives. Support and adequate preparation were key facilitators in easing stroke caregivers into their role.ImpactThe findings from this review can be used to guide future implementations of caregiver education programmes and comprehensive discharge planning for stroke survivors.
Social determinants of health on human immunodeficiency virus care quality in Indonesia
Authors: Qur'aniati Nuzul , Sweet Linda , De Bellis Anita , Hutton Alison 
Published: August 2022

AbstractAimsThe aim was to examine the social determinants of health on human immunodeficiency virus care quality for children in Indonesia.DesignA qualitative design using constructivist grounded theory methods was utilized.MethodsData were collected between 2019 and 2020 using in‐depth‐ interviews and memo writing. In total, 23 semi‐structured individual interviews with healthcare professionals, 12 with children with human immunodeficiency virus, and eight family members were conducted. Data were analysed with the two‐step initial coding and focused coding, along with the constant comparative method, theoretical sensitivity and memo writing.ResultsFive themes were constructed from participants' perspectives on human immunodeficiency virus care for children: (1) living with a low‐socioeconomic status, (2) lacking instrumental support, (3) experiencing complicated procedures for public health insurance, (4) limited Human Immunodeficiency Virus care services for children and (5) lacking care coordination, policies and practices.ConclusionChildren living with human immunodeficiency virus had poor health outcomes, due to having a low‐socioeconomic status, reduced access to healthcare, coupled with a lack of social support services.ImpactThis study demonstrated how the social determinants of health negatively impact the quality of care for Indonesian children with human immunodeficiency virus and their families. Understanding these determinants would benefit health professionals, in particular nurses, to consider these factors in their assessment to create a holistic care plan for children living with human immunodeficiency virus and their families. Addressing the social determinants of health would beneficially enhance outcomes and well‐being of children living with human immunodeficiency virus health in Indonesia.
Animals and Relational Egalitarianism(s)
Authors: Bengtson Andreas 
Published: August 2022

ABSTRACTAccording to relational egalitarianism, a society is just insofar as the relations in that society are equal. Exclusively, relational egalitarians have been concerned with why humans, in particular adults, must relate as equals. This is unfortunate since relational egalitarians claim to be in line with the concerns of real‐life egalitarians; but real‐life egalitarians, such as vegans and vegetarians, clearly care about injustices committed against non‐human animals. In this article, I thus explore the role of non‐human animals in relational egalitarianism. I distinguish four accounts of relational egalitarianism and argue that they differ in what they imply for relationships between humans and animals. Interestingly, it will also become clear that in relational egalitarianism, a relation may not only be unequal or equal; it may also be non‐unequal.