bluuebunny/crossref_metadata_2025_split huggingface dataset:
SEPT2 Protein Crotonylation Promotes Metastasis and Recurrence Through AKT Pathway in Hepatocellular Carcinoma and is Associated with Poor Survival
Authors: Zhang XinYue , Liu ZeXian , Zhang YiFan , Xu LiXia , Chen MengKe , Zhou YuFeng , Yu Jun , Li XiaoXing , Zhang Ning 
Published: February 2022

Abstract
Background
Hepatocellular carcinoma (HCC) metastasis and recurrence lead to therapy failure. Posttranslational modification (PTM) mechanisms in HCC, especially those of recently discovered PTMs, such as lysine crotonylation (Kcr), are still poorly understood.
Methods
Kcr protein levels in HCC cell lines of MHCC-97H (highly invasive) cells and MHCC-97L (minimally invasive) were detected through stable isotope labeling by amino acids in cell culture (SILAC) and liquid chromatography with tandem mass spectrometry (LC–MS/MS). The differentially crotonylated proteins in these two cell lines were identified through bioinformatics analysis. Protein Kcr was confirmed by immunoprecipitation (IP) and western blotting (WB). The function of Septin2 (SEPT2) crotonylated at K74 (SEPT2-K74cr) in metastasis was examined in vivo and in vitro. The clinical significance of SEPT2-K74cr in HCC patients was determined by immunohistochemistry (IHC) assay.
Results
The crotonylation rate was higher in highly invasive cells, and higher crotonylation level in HCC cells facilitated cell migration and invasion. The crotonylated protein SEPT2 was significantly hypercrotonylated in highly invasive cells, and the de-crotonylated mutation of K74 in SEPT2 impaired SEPT2 GTPase activity and inhibited HCC metastasis in vitro and in vivo. Mechanistically, SIRT2 decrotonylated SEPT2, and P85α was found to be the downstream effector of SEPT2. SEPT2-K74R facilitated P85α degradation, suppressing PI3K pathway and inhibiting the epithelial–mesenchymal transition. SEPT2-K74cr was correlated with poor prognosis and recurrence in HCC patients.
Conclusions
We revealed the role of nonhistone protein crotonylation in regulating HCC metastasis and invasion. Crotonylation facilitated cell invasion through the crotonylated SEPT2-K74 (cr)-P85α-AKT pathway. High SEPT2-K74 crotonylation predicted poor prognosis and a high recurrence rate in HCC patients.
Sleep Disturbances In Adults With Untreated Primary Brain Tumors: Prevalence And Effect On Quality Of Life
Authors: Lin Pei-Ching , Chen Pin-Yuan , Wei Kuo-Chen , Lin Jian-her , Lin Mei-Ru , Wang Huan-Chih , Chiu Hsiao-Yean 
Published: February 2022

Abstract
Purpose: To investigate the frequency of sleep disturbances and their effects on the quality of life of adults with untreated primary benign and malignant brain tumors.Methods: This prospective study recruited 68 and 35 patients with newly diagnosed benign and malignant brain tumors, respectively. All participants completed the Chinese versions of Athens Insomnia Scale, Epworth Sleepiness Scale, Pittsburgh Sleep Quality Index, Hospital Anxiety and Depression Scale, and EORTC-QLQ-BN20 and the Taiwanese version of the Brief Fatigue Inventory. An actigraph was used to measure sleep parameters, namely total sleep time, sleep onset latency, wake after sleep onset, sleep efficiency, and dichotomy index (I<O), for at least 3 consecutive days before treatment.Results: The majority of the patients with benign and malignant tumors had meningioma (57.4%) and glioblastoma (40%), respectively. In patients with primary brain tumors, the prevalence of insomnia, poor sleep quality, and excessive daytime sleepiness was 59.2%, 77.7%, and 4.9%, respectively. Only 36 participants completed actigraphic assessments (I<O = 95.4), and 61.1% of them experienced circadian disruption (I<O ≤ 97.5). Insomnia was the only sleep parameter that significantly affected quality of life after controlling for potential confounders (B = 0.55, p = 0.02, adjusted R2 = 0.60).Conclusion: More than 60% of the patients with primary malignant and benign brain tumors experienced insomnia, poor sleep quality, and circadian disruption. Insomnia independently correlated to quality of life before cancer-related treatment. Health-care providers can apply these findings to design effective interventions targeting sleep disturbances to improve quality of life in this population.
Research on Constant Force Polishing Method of Curved Mold Based on Position Adaptive Impedance Control
Authors: Chang Guangsheng , Pan Ri , Xie Yinhui , Yang Jinxing , Yang Yong , Li Jun 
Published: February 2022

Abstract
The quality and life of the injected product is affected by curved mold surface quality, so the polishing of the mold is essential. Small polishing tool are controlled by constant displacement polishing in the conventional method. The force will vary when polishing the mold with small polishing tool, thus affecting the surface quality of the mold. The robot constant force polishing method is proposed to solve this problem, which is achieved by a position-based impedance control algorithm. The proposed method can produce continuous and stable force. The effect of the constant force control method on the surface quality is analyzed by simulating this paper, proving the correctness of the constant force control method. The initial roughness of the mold surface is 1.912 μm , the result is 1.419 μm in the traditional method, however the result of constant force polishing is 0.807 μm . The percentage of the decrease in surface roughness is 25.78% in the conventional method, whereas the reduce percentage is 57.79% in the constant force control(CFCP) polishing method. The feasibility of the constant force controlled polishing method is verified.
clicSANDMac for OSeMOSYS: a user-friendly interface for macOS users using open-source optimisation software for energy system planning
Authors: Cannone Carla , de Wet Nicki , Shivakumar Abhishek , Kell Alex , Tan Naomi , Yeganyan Rudolf , To Long Seng , Harrison John , Howells Mark 
Published: February 2022

Abstract
clicSAND is a user interface for OSeMOSYS users to analyse energy system models in terms of investment planning and optimal allocation of resources. The first version was only available for Windows users with at least 8 GB RAM and an installed Windows Access database to visualise the results. This paper presents an updated version of the software called clicSANDMac, which was specifically developed for macOS OSeMOSYS users and overcomes the previous limitations – as described in Section 1. The main changes to the software, its functionalities, and configuration are presented in Section 2. The paper ends with Section 3, which provides suggestions for future work and the potential impact of the clicSANDMac software.
Nuclear Excitation by Muon Capture
Authors: Gargiulo Simone , Gu Ming , Carbone Fabrizio , Madan Ivan 
Published: February 2022

Abstract
Efficient excitation of nuclei via exchange of a real or virtual photon has a fundamental importance for nuclear science and technology development. Here, we present a new mechanism of nuclear excitation based on the capture of a free muon into the atomic orbits (NEμC). The cross section of such a new process is evaluated using the Feshbach projection operator formalism and compared to other known excitation phenomena, i.e. photo-excitation and nuclear excitation by electron capture (NEEC), showing up to ten orders of magnitude increase in cross section. NEμC is particularly interesting for MeV excitations that become accessible thanks to the stronger binding of muons to the nucleus. The binding energies of muonic atoms have been calculated introducing a state of the art modification to the Flexible Atomic Code (FAC). An analysis of an experimental scenarios in the context of modern muon production facilities shows that the effect can be detectable for selected isotopes. The total probability of NEμC is predicted to be $ P \approx \SI{1e-6}{}$ per incident muon in a beam-based scenario. Given the high transition energy provided by muons, NEμC can have important consequences for isomer feeding and particle-induced fission.
A-One Health Approach on the Evaluation of COVID-19 Risk Perception and Factors Associated with the COVID-19 Vaccine Acceptance in Nigeria, West Africa
Authors: Ejeh Francis Enenche , Buba Deborah Maigawu , Reuben Rine Christopher , Jajere Saleh Mohammed , Denue Ballah A , Abunike Sarah Adamma , Malgwi Bashir Usman 
Published: February 2022

Abstract
Background
Effective elimination of the COVID-19 pandemic is dependent on the COVID-19 vaccines that are readily available and acceptable to the public. This study evaluated the COVID-19 risk perception and factors associated with COVID-19 vaccine acceptance in Nigeria.
Methods
A cross-sectional online survey with a structured questionnaire employing a Snowball sampling method was administered among Nigerian adults from the beginning of COVID-19 mass vaccination in March 2021 till December 2021. Data collected were analysed using descriptive statistics, Chi-square and multivariable regression. Participants’ general knowledge regarding COVID-19, willingness to accept COVID-19 vaccines, perception of seriousness, susceptibility of COVID-19 were assessed.
Results
From the 402 responses received, the mean age of the respondents was 35.1 ± 11.9 years, with the majority being males (288 (71.6%)) and non-health workers (349 (86.8%)). Overall, COVID-19 knowledge was good, with a mean score of 6.2 ± 0.19 (range 0–8) and a COVID-19 vaccine acceptance rate of 65.67%. We found a consistent positive relationship between respondents’ COVID-19 knowledge and their willingness to accept COVID-19 vaccines. Respondents who believed that the 5G network is not the cause of COVID-19 were two times more likely to receive the COVID-19 vaccine (aOR 2.38; 95%CI 1.05–5.36; p = 0.04). Furthermore, our comparisons of respondents’ age groups and marital status revealed higher odds of being willing to accept COVID-19 vaccines among respondents who were age 50 ≥ years old (aOR 7.35; 95% CI: 1.69–31.93; p = 0.008) and those who were singles (aOR 4.39; 95% CI: 1.86–10.33; p = 0.001), respectively. However, non-healthcare workers with high income and educational status were unwilling to accept COVID-19 vaccines. Surprisingly, although 303 (75.4%) of the respondents believed COVID-19 is a severe disease, only 119 (45.1%) are confident of contracting the COVID-19 should they fail to adhere to infection prevention and control (IPC) measures.
Conclusion
the study revealed that the intention to receive the COVID-19 vaccine varied across demographic characteristics, level of education, income and employment status, and perceived severity and susceptibility to COVID-19. We recommend continuous public health education on the risk of COVID-19 and the vital role vaccine will play in ending this pandemic.
Research through action: Study design and protocol on the implementation of an integrated place-based primary intervention in a multicultural context
Authors: Maillet Lara , Manceau Luiza Maria , Desjardins France , Gagnon Suzanne , Naraziah Lavanyah , Malham Sabina Abou 
Published: February 2022

Abstract
Our project specifically aims at improving the adaptation capacity of primary services in order to answer the complex needs of vulnerable people. The aim is to co-build, with our collaborators and partners, environment-based strategies enabling the coordination of primary services offered by health, social and community responders all the while ensuring the continuity of care (informational, relational and contact) of vulnerable people, especially refugees. A particular attention is brought toward the experiential knowledge of the health system users. This is why at least three citizen-partners are part of the research team since the beginning of the project.Goals: This research-action aims at implementing a “meshing innovation”, meaning an intervention that is integrated, lasting and based on the needs of a community located in a Sherbrooke neighbourhood in order to improve the care of refugee people in a continuum of primary services. To reach this goal, we have 5 specific objectives. The overall goal of this project is to improve the services trajectory in the health and social services network for refugee people in Quebec. The implementation of a meshing innovation, through this pilot project, is a first step toward this overall goal. Method: This project falls within a participative research approach, based on the symmetry principle of the researchers and field stakeholders’ knowledge. To do so, we choose three distinct sources of data: (1) literature review, (2) focus group (N=9 twice), and (3) semi-structured interviews (N=10).Expected results: Concretely, an Implementation guide of establishment strategies for integrated interventions enabling the improvement of primary care for refugees will be written and will constitute the basis for an appropriation workshop for the members of the two joint research networks focused on primary practices (RRAPPL) (Université de Laval and Université de Sherbrooke) and, eventually, in other fields interested in adapting and implementing these strategies. In addition to this guide, we wish to facilitate the care of refugees by family practitioners of the territory; this is why many of them are part of the project. Explicit ties will help raising awareness toward other family practitioners working in medical clinics of the territory while trying to facilitate a specific attribution to these practitioners through the Quebec Family Doctor Finder (GAMF). With this project, we strongly hope to promote the vulnerability factors of refugees to the Health and Social Services Department (MSSS) and to the Quebec General Practitioners Federation (FMOQ) in order to change the priority at the GAMF. Finally, a scientific publication will be written for an international journal.
Surface Functionalization of Organosilica Nanoparticles with Au Nanoparticles inhibits Cell Proliferation and Induces Cell Death in 4T1 Mouse Mammary Tumor Cells for DNA and Mitochondrial-synergized Damage in Radiotherapy
Authors: Mochizuki Chihiro , Kayabe Yukihito , Nakamura Junna , Kato Shigeki , Igase Masaya , Mizuno Takuya , Nakamura Michihiro 
Published: February 2022

Abstract
Radiotherapy is one of the most effective cancer treatments. Au nanoparticles (NPs) are one of the most used X-ray sensitizing materials however the effective small sub-nm size of Au NPs used for X-ray sensitizers is disadvantageous for cellular uptake. Here, we propose the surface functionalization of organosilica NPs (OS) with Au NPs (OS/Au), which combined the 100 nm size of OS and the sub-nm size of Au NPs, and synthesized effective Au materials as an X-ray sensitizer. The X-ray sensitizing potential for 4T1 mouse mammary tumor cells was revealed using a multifaceted evaluation combined with a fluorescence microscopic cell imaging assay. The number of polyethyleneimine (PEI)-modified OS (OS/PEI) and OS/Au (OS/Au/ PEI) uptake per 4T1 mouse mammary tumor cell was the same; however, 4T1 cells treated with OS/Au/PEI exhibited significant inhibition of cell proliferation and increases in cell death by X-ray irradiation at 8Gy. The non-apoptotic death of OS/Au/PEI-treated 4T1 cells was increased by DNA and mitochondrial-synergized damage increase and showed potential applications in radiotherapy.
Structural Equation Model on Creativity and Innovation of Library Personnel in Davao Region
Authors: Fajagutana MAEdLS Archie B. , Guhao Jr Eugenio S. 
Published: February 2022

Abstract
The purpose of the study was to establish the best fit model of creativity and innovation as influenced by organizational commitment, employee engagement and work environment of library personnel in Davao Region. A total of 400 library personnel were selected using the universal sampling technique. Structural equation modelling was used to find the best fit model. The results showed that organizational commitment, employee engagement and work environment have a significant relationship with creativity and innovation of library personnel. Moreover, the best fit Model 4 depicted the direct causal relationship of organizational commitment, employee engagement and work environment was found to be the final and best fit model on creativity and innovation of library personnel.
A new target-oriented imperialist competitive-based algorithm to solve target coverage problem in directional sensor networks
Authors: Saadati Mahshad , fard Mojtaba Mousavi , Mohamadi Hosein 
Published: February 2022

Abstract
Today, directional sensor networks (DSNs) have received a great deal of attention. A DSN is composed of several self-configurable directional sensors with adjustable spherical sectors of limited angles, which can provide coverage on several targets distributed randomly within a defined area. One of the most significant problems associated with this type of networks, which has been already proved as an NP-hard problem, is monitoring the maximum number of targets by means of minimum number of sensors. Another aspect of the problem is how to extend the lifetime of such networks concerning the limited power source of the sensors. An appropriate solution to this problem is the use of scheduling technique in environments with densely-distributed sensors. In this paper, we proposed an imperialist competitive-based scheduling algorithm capable of providing near-optimal coverage through determining the priority of the targets that can be monitored by fewer sensors. To evaluate the proposed algorithm performance, the obtained results were compared to those of a target-oriented greedy-based algorithm already proposed in the literature. The final results showed the acceptable competency of the proposed algorithm in terms of solving the problem in hand.
Fighting for water in South Africa: public participation, water rights claiming and strengthening governance
Authors: Masiangoako Thato , Khunou Kelebogile , Potter Alana 
Published: February 2022

AbstractCommunities in South Africa employ a diverse range of strategies to actively claim their right to water. This paper examines two rights claiming strategies – protest and litigation – through the lens of two case studies. The first case study examines the struggles of the residents of Makhanda, a small town in the predominantly rural Eastern Cape Province, who formed a coalition to advocate for the dissolution of the municipal council for failing to fulfil its constitutional mandate to provide basic services. The second case examines the struggles of the residents of Marikana, an informal settlement in the City of Cape Town, where residents are forced to live in unlit, unhygienic and undignified conditions as a result of inadequate services provision. Although access to water is a justiciable right in South Africa, there is a curious paucity of legal rights mobilisation, with only one court case reaching the Constitutional Court. The article presents the following findings. First, communities employ different methods to claim their water rights, including engagement with government through formal channels, mobilisation, protest, litigation and self-supply. Water is a justiciable human right. Second, litigation is a valuable component of rights-claiming but is most effective if used alongside other strategies like community organisation and protest. Third, water rights can be achieved alongside struggles to secure other rights, like the right to housing, or holding local government accountable. In the two case studies, the legal tools of land expropriation and provincial intervention were employed to indirectly gain access to water services. Finally, community mobilisation, combined with strategic partnerships, plays a critical role in sustaining long-term efforts to claim water rights.
Developing a novel tool for assessing water service sustainability in rural areas of sub-Saharan Africa
Authors: Mvongo Victor Dang , Defo Célestin , Tchoffo Martin 
Published: February 2022

Abstract
The present study aimed to develop a tool for assessing water service sustainability in rural areas of sub-Saharan Africa. This tool is called the ‘Water Service Assessment Tool’ (WaSAT) and is based on the Water Service Sustainability Index (WSSI) which consists of 21 indicators grouped into six dimensions (economic, environmental, social, technical, institutional, and governance). The WaSAT was developed using Microsoft Excel and PowerApps platforms. This tool provides a solid baseline on the sustainability of water services and identifies priority actions to be taken to move services toward sustainability.
Climate change impact on the estimation of reference evapotranspiration, water requirement, and irrigation requirement in irrigated areas (a case study: Bardsir plain)
Authors: Rajabi Morteza , Jalalkamali Navid , Naghizadeh Mahdi 
Published: February 2022

Abstract
Climate change impacts have been felt deeply by farmers of the Bardsir region, which is situated in the southeast of Iran. The current research focuses on the climate change impacts on the region's agricultural sector by the horizon of 2051. In the first step, by means of data generated by two micro lysimeters, the best-localized formula for estimating reference evapotranspiration was derived. Then the irrigation requirements of wheat, barley, rape, corn, alfalfa, potato, and onion crops were estimated by GFDL-ESM2M and Had GEM2-ES model outputs with two scenarios, RCP4.5 and RCP8.5. According to the findings, under both scenarios, the irrigation requirements of all plants will be increasing. Assuming that the current water consumption patterns remain unchanged, this will increase the total annual water demand of the plain from its present value of 331.9 to 369.66 million cubic meters (MCM) in the RCP4.5 scenario and 375.58 MCM in the RCP8.5 scenario based on GFDL-ESM2M model output. These values would be 345.11 and 349.85 MCM for RCP4.5 and RCP8.5, respectively, based on Had GEM2-ES model output by 2051. To conserve the current cultivation area, GCM models indicate, under a pessimistic scenario, even after modernizing the irrigation systems of the region the plain will encounter negative balance due to groundwater overdraft.
Soil loss estimation and prioritization using geographic information systems and the RUSLE model: a case study of the Anger River sub-basin, Western Ethiopia
Authors: Moisa Mitiku Badasa , Dejene Indale Niguse , Merga Biratu Bobo , Gemeda Dessalegn Obsi 
Published: February 2022

Abstract
Soil erosion is a major environmental problem that affects people's livelihoods and environmental health, particularly in developing countries. The present study aimed to identify soil erosion hotspot areas and prioritization in the Anger River sub-basin for conservation planning. The Revised Universal Soil Loss Equation (RUSLE) model and geospatial technologies were adopted to identify soil erosion hotspot areas and prioritization of the sub-watershed for conservation planning. Key parameters such as rainfall data, soil data, slope length and steepness factor, cover management, and conservation practices were used to estimate potential soil erosion risk in the sub-watershed. The results showed that the annual soil loss rate in the Anger River Sub-basin ranged between 0 and 932.6 t/ha/year with a mean annual soil loss of 83.7 t/ha/year. About 1,140.7 km2 (43.6%) and 220.6 km2 (8.4%) were categorized under very severe and severe soil loss types, respectively. The mid- and upstream areas, as well as the steeper parts of the sub-watershed, were highly exposed to soil erosion. This research provides tangible evidence in the decision-making process for soil and water conservation practices at a sub-watershed scale. Moreover, further research should be conducted at a micro-watershed scale to minimize the effects of soil erosion on the health and sustainability of the watershed.