bluuebunny/crossref_metadata_2025_split huggingface dataset:
What is the appropriate use of CT in combination with tumor marker and medical examination findings in the follow-up of postoperative patients with ovarian cancer?
Authors: Matsutani Hiroki , Nakai Go , Fujiwara Satoe , Takahashi Satoru , Yamamoto Kazuhiro , Ohmichi Masahide , Osuga Keigo 
Published: April 2022

Abstract
Background
The aim of this study was to establish the appropriate use of CT in combination with tumor marker and medical examination findings in the follow-up of postoperative patients with ovarian cancer based on the recurrence pattern in CT imaging and clinical findings.
Methods
The subjects were 194 consecutive patients with primary ovarian cancer treated at our hospital between 2014 and 2019. Recurrence patterns on chest and abdominopelvic CT images obtained for routine postoperative follow-up were evaluated retrospectively to optimize scan range. Medical records were reviewed to determine whether clinical signs and symptoms (patient-reported symptoms and transvaginal ultrasound findings) and tumor markers levels can be sufficiently reliable indicators of recurrence.
Results
A total of 890 CT examinations were performed for the 194 patients. Data from the 146 patients with no residual disease at the first CT after standard treatment were analyzed. Recurrence was detected by CT in 15 patients: abdominopelvic recurrence alone in 12 patients, and concurrent chest and abdominopelvic recurrence in 3 patients (2.1%). Abdominopelvic recurrence preceded chest recurrence in all cases. At the time of CT-based recurrence, 13 patients (87%) had medical examination findings and/or elevated tumor markers, while the remaining 2 patients had neither.
Conclusions
Regular medical examination and tumor markers were useful for detecting recurrence, but overlooked 13% of patients with recurrence. This indicates that routine abdominopelvic CT is essential for follow-up. However, routine chest CT may not be beneficial unless abdominopelvic recurrence is seen.
Indications for the potential of Cry1Ab1 for inhibiting aphid development and virus transmission
Authors: Jin Liang , Zhang Binwu , Zhao Xiaodi , Aguila Luis Carlos Ramos , Lin Yi 
Published: April 2022

Abstract
Cry1A-type toxins are insecticidal proteins from Bacillus thuringiensis that are widely used to control Lepidoptera pests, and they are believed to be useless for the control of Hemiptera pests. In this paper, the purified Cry1Ab1 toxic core rarely killed peach aphids (Myzus persicae), as its Lethal Concentration 50 (LC50) was up to 1308.6 μg/ml, as measured using the membrane-encapsulation method. We then identified the proteins that bind to the Cry1Ab1 toxic core in M. persicae using pull-down assays and liquid chromatography−tandem mass spectrometry (LC-MS/MS), and then analyzed the associated functions of these proteins using the STRING database. GPN-loop GTPase 2, beta-actin, ATP synthase subunit alpha and an unknown and annotated protein, which are mainly involved in cell phagocytosis, RNA polymerase, cellular oxidative phosphorylation and other related functions, were the proteins that bound to the Cry1Ab1 toxic core. Indications from docking showed that Cry1Ab1 toxic core, ATP synthase subunit alpha and beta-actin or Cry1Ab1 toxic core, ATP synthase subunit alpha and GPN-loop GTPase 2 being a complex to exert effects. Based on the identification of Cry1Ab1-binding proteins from M.persicae, we presented here the molecular clues that Cry1A exert a negative effect on aphid growth and development, and we also proposed that Cry protein had the ability to disturb virus transmission by aphid. The two indications will result in new insights for aphid-effective Cry evaluation and improvement.
Clinical analysis of osteoporotic vertebral oblique compression fracture treated with bone cement combined with balloon
Authors: Qian zhong-lai , Deng Lei , Hu Xia-Yu , Hua Xi , Pan Ze-Jun , Zhou Quan , Li Bao-Xin , Lv Nan-Ning 
Published: April 2022

Abstract
Objective： To explore the clinical effect of bone cement combined with balloon expansion in the treatment of osteoporotic vertebral oblique compression fracture.Methods： This study retrospectively reviewed the patients who were diagnosed with osteoporotic vertebral oblique compression fracture between January 2017 and July 2019. According to the method of surgery, 41 patients received bone cement treatment alone (group A) and 44 patients received bone cement combined with balloon expansion (group B). The visual analogue scale (VAS), oswestry disability index (ODI), scoliosis angle (SA), height of long side (HL), height of short side (HS) and lateral height difference (LHD) before operation and 3 days and 1 year after operation were compared between the two groups. The operation time, fluoroscopic time, hospital stay, cement volume and complications were also compared between the two groups.Results：The VAS and ODI differed significantly between the groups 1 year after operation(P＜0.05). Compared with the preoperative results, there were significant differences in SA, HL, HS and LHD 3 days and 1 year after surgery(P＜0.05). There were significant differences in SA, HS and LHD 3 days and 1 year after surgery between the two groups(P＜0.05). A total of 21 patients in group A and 6 patients in group B experienced scoliosis after operation, there were also significant differences between groups(P＜0.05).Conclusions：Bone cement combined with balloon expansion and bone cement alone are all effective in the treatment of osteoporotic vertebral oblique compression fracture, but bone cement combined with balloon expansion had better long-term clinical efficacy.
Environmental sustainability evaluation of dairy manure bedding regeneration system based on emergy analysis and life cycle assessment method
Authors: Sun Xinran , Liu Yu , Li Yangyang , Chai Shengyang , Zhang Hao , Liu Yongdi , Zhao Guishen , Li Ji , Xu Ting , Wei Yuquan 
Published: April 2022

Abstract
Dairy farm bedding can be produced by composting technology using dairy manure, which offers advantages in terms of cost, availability and economic value. However, few information is available on the environmental sustainability and impacts for manure recycling systems for based on different composting methods. The resource-environmental impact and eco-economic sustainability of two manure bedding regeneration systems: forced-ventilation static-stack aerobic fermentation (FVSSAF) system (Scenario A) and bedding recovery unit (BRU) system (Scenario B) were evaluated in this study. The life cycle assessment yielded a combined environmental impact potential of 0.0170 for scenario B, much lower than the 0.1970 for scenario A. The emergy analysis showed that scenario B has a higher emergy input of about 1.34E + 18 sej/a than scenario A with 6.34E + 17 sej/a. This was due to the fact that scenario B can handle more dairy manure. Form the emergy indices of the two systems, scenario B had lighter environmental pressure and higher sustainability. In contrast, the BRU system had economic advantages and ecological sustainability, which was more suitable for large dairy farms. The trade-offs between environmental consequences, resource efficiency and economic benefits were analyzed from several perspectives in this study, and would help stakeholders to have a new understanding when choosing a bedding recycling treatment option.
RCT of an Online MBSR Intervention with Metastatic Breast Cancer Patients
Authors: Hydeman Jennifer , Ernhout Carrie , Attwood Kristopher , Hong Chi-Chen 
Published: April 2022

Abstract
PurposeThe diagnosis and treatment of cancer can result in an array of psychological and physical sequelae for patients. Mindfulness-Based Stress Reduction (MBSR) is a well-validated intervention aimed at reducing emotional distress and improving long-term treatment effects in cancer patients. Further studies employing more powerful control group designs are needed to validate MBSR in patients with advanced disease and in novel clinical settings that facilitate enrollment. Patients diagnosed with metastatic disease are highly impacted by their disease and treatment and are an under-examined high-risk population. Methods This study aimed to determine the efficacy of a 6-week modified online MBSR intervention in improving psychological and physical symptoms associated with quality-of-life, as well as biomarkers associated with their disease trajectory, in patients diagnosed with metastatic breast cancer. Results The 6-week online intervention was found to significantly improve measures of mindfulness and several psychological/quality of life indices. There were no intervention effects on biomarkers of stress or inflammation, although improved levels of mindfulness due to the intervention were negatively correlated with several pro-inflammatory cytokines, including IL-6, IL-8, and TNFα. Patients indicated high satisfaction with the content and delivery method of the intervention. Conclusions Addressing the multidimensional needs of metastatic patients requires service delivery models that integrate powerful interventions into care settings while minimizing participant burden. This study developed a novel online MBSR treatment for distressed metastatic breast cancer patients that was found to be effective in improving mindfulness and several areas pertinent to patient quality of life.
Association of urinary phthalate metabolites with estrogen receptor related cancers in American adults: A Nationwide Study, NHANES 2003-2006
Authors: Li Yifan , Zhou Xianghong , Yang Qiuxiang , Jiang Zhongyuan , Hu Dan , Wang Mingda , Wang Sheng , Jin Kun , Wei Qiang , Qiu Shi , Yang Lu 
Published: April 2022

Abstract
Background: Phthalates are chemical substances widely used in human consumer goods. Studies have shown that phthalates exposure can affect the physiological function of estrogen receptor (ER). However, there is no comprehensive discussion on the association between phthalates exposure and ER-related cancer risk.Objective: We conducted a cross-sectional study of urinary phthalate metabolite concentrations and self-reported ER-related cancers among 3,015 participants from two cycles of the national health and Nutrition Examination Survey (NHANES), 2003-2006.Methods: Seven compounds of phthalate metabolites were examined as expoure biomarkers. We used multivariate logistic regression to estimate odds ratio (ORs) and 95% confidence intervals (CIs), adjusting for potential confounding factors. The concentration of phthalate metabolites is non-normal distribution, so quantile and log-transformation are used for analysis. Account for urine dilution, the creatinine corrected phthalate concentration was applied in our analysis. In addition, we also conducted sensitivity analysis by gender stratification and trend test to explore whether there is a concentration increase effect, so as to explore the relationship between these seven phthalate metabolites and the risk of ER-related cancers.Results: We observed a higher prevalence of ER-related cancers in the maximal quantile of MCNP (OR=2.37; 95%Cl=1.01-5.55) in adjusted model. Meanwhile, trend test also confirmed that MCNP had a positive trend with the risk of ER-related cancer (P=0.036). In subgroup analysis, the higher concentration of MCNP, the higher the risk of breast cancer. At the same time, the trend test verified our results: the results are positive (OR=3.68;95%Cl=1.15-11.74) (P=0.014).Conclusion: We provide the main evidence that urinary phthalate metabolites concentrations are positively correlated with ER-related cancers. The positive relationship between MCNP exposure and breast cancer risk is more obvious in women. Further causal studies are needed to confirm the findings in our analysis and clarify the underlying mechanisms.
Free-living Bacterial Community, Abundance and Edaphic Factors Response to Soil Depth Gradient under Contrasting Fertilization in Sugarcane Continuous Cropping Field
Authors: Zhang Hua , Fallah Nyumah , Tayyab Muhammad , Yang Ziqi , Pang Ziqin , Zhang Caifang , Lin Zhaoli , Stewart Lahand James , Ntambo Mbuya Sylvain , Abubakar Ahmad Yusuf , Lin Wenxiong 
Published: April 2022

Abstract
Although the effects of fertilization on soil N-fixing bacterial community and abundance have been investigated extensively in the surface soil (0–20 cm), the response of free-living bacterial community and abundance under contrasting fertilizations in a consecutive sugarcane monoculture field and their relationship with edaphic factors in the dipper (20–60 cm) soil layer remain elusive. In the current study, nifH gene amplicon sequencing was used to investigate N2-fixers bacterial community and abundance by leveraging high-throughput sequencing (HTS). Moreover, edaphic factors in three soil depths (0–20, 20–40 and 40–60 cm) under control (CK), organic matter (OM), biochar (BC) and filter mud (FM) amended soils were investigated. Our analysis revealed that β-glucosidase and phosphatase activities, and ammonium (NH4+-N), nitrate (NO3−-N), total carbon (TC), total nitrogen (TN) and available potassium (AK) were considerably higher in 0–20 cm in all treatments. Proteobacteria and Geobacter were dominant in all the samples, while 0–20 cm was overwhelmingly occupied by Anabaena, Enterobacter and Desulfovibrio in BC and FM amended soils, followed by Methylomonas in 20–40 cm under BC treatment. We also noticed that soil depth was the main environmental gradient that influenced soil diazotrophs and edaphic factors rather than fertilization. Together, these results suggest that soil depth had a profound impact on N-fixing bacteria, edaphic factors than fertilization regimes. Moreover, these findings were more pronounced in 0–20 cm soil depth under organic amendments compared with CK.
Correlation between dimensions of brain metastases and therapeutic results after stereotactic radiosurgery
Authors: Neto Eliseu Becco , Bastos Dhiego Chaves de Almeida , Figueiredo Eberval Gadelha , Filho Francisco de Assis de Souza , de Souza Rodrigo Becco , Prabhu Suit S 
Published: April 2022

Abstract
OBJECTIVE: Stereotactic radiosurgery (SRS) is an effective therapeutic method to treat brain metastases (BM). A current debate considers BM dimension as an important issue regarding SRS therapeutic result. The aim of this study was to evaluate the dimensional progression of BM after SRS and identify factors related to patients and BM leading to local recurrence.METHODS: Patients eligible for this study were those with BM from non-small cell lung cancer (NSCLC) who had been consecutively treated with SRS in 2010-2015. The dimensions of BM were measured by volume and greater diameter by nuclear magnetic resonance imaging (MRI) in T1-weighted contrast weighting using the Elements software (Brainlab). Dimensional data of BM were collected before the performance of SRS and after performing them during the follow-up of outpatients. After identifying the dimensions of BM in time progression, lesions that presented therapeutic success (reduction of BM dimensions) and local recurrence (growth of BM after SRS) were identified. Next, statistical evaluations were performed by statistical analysis at 12 months, considering epidemiological features presented by patients as well as topographic characteristics and radiological aspects of BM. RESULTS: There was no correlation, after 12 months of the performance of SRS, between initial volume of BM and local recurrence. The results obtained identify a non-cystic BM, and brain left sided BM as elements related to higher progression free survival after 12 months of SRS. CONCLUSION: Considering therapeutics in patients presenting BM, the correlation between initial volume and failure within 12 months after SRS had no statistical significance, BM located on the right side of the brain showed therapeutic fail within 12 months after SRS. Longer time of observation may be useful to confirm such results.
Patients’ Perceptions and Experiences of the COVIDCare@Home Program: Insights from a Mixed Methods Study
Authors: Jeffs Lianne , Zeng Rui Lin , Agnew Theresa , Schonewille Noah , Austin Tujuanna , Oliveira Marie , Loganathan Mayura 
Published: April 2022

Abstract
Background
Virtual models of health service delivery are being offered to patients diagnosed and recovering from COVID-19 as a key strategy to minimize the spread of the variants. Although evidence is growing in this area, more is needed to understand the experiences and perceptions of patients and their care partners associated with virtual and telehealth care to inform future care delivery efforts beyond our current pandemic. In this context, a study was undertaken to explore a virtual primary home care program led by a nurse practitioner developed for acute and post-acute COVID-19 patients and their care partners.
Methods
The study employed a mixed methods design that included a cross-sectional patient survey and semi-structured interviews with a sample of COVID-19 patients.
Results
The CC@H program was reported by study participants to have several positive benefits including needs being met and better able to manage their care at home. Qualitative results further elucidated three key themes easing anxiety by providing emotional support and checking in; 2) providing holistic compassionate care to enable self-management; and 3) viewing virtual care as efficient and convenient.
Conclusions
Our study provides interesting insights into the experiences and perceptions of COVID-19 patients receiving care through a primary health care nurse practitioner-lead virtual care program that may be useful to other organizational efforts.
The enhanced extraction of rare earth elements from coal gangue and coal fly ash
Authors: Zhang Rui , Zhang Chunming , Cao Yan 
Published: April 2022

Abstract
Rare earth elements (REEs) are unrenewable, uneven distributed and less productive worldwide, but technological-critical and strategic important. Searching for alternative REEs resource has motivated many interests and technological advancement. The recent example was studies launched by U.S. on the recovery of REEs from coal and coal byproducts, since substantial REEs have been found in coal recourses despite in their lower occurrence. The extraction of REEs from coal and coal products face many technological challenges because REEs mainly exist in the inorganic lattice structure of coal and its byproducts, such as silicon-aluminum oxides. In this study, coal gangue and fly ash were selected as two representative coal by-products to extract REEs. The extraction of their REEs was alternative to the direct conventional acid leaching procedure. In this study, the realization of the CFA activation was initialized before moving-on to the conventional acid leaching. The activation of selected coal byproducts was subject to the calcination at the elevated temperatures using sodium carbonate (Na 2 CO 3 ). Studies regarding effects of the temperature and the Na 2 CO 3 dosage during the calcination as well as pH adjustment during leaching on the following-up maximize the extraction efficiency of REEs were intensively investigated. The results showed that the best practices achieved by 93.2% and 95.8% for coal fly ash and coal gangue in the extraction efficiency of REEs, upon the mixing molar ratio of silicon-aluminum oxides in coal byproducts and sodium carbonate at 1:1, the calcination temperature at 850°C and the acid leaching pH at 2.
Impact of water-quality modelling simplifications on the optimal positioning of sensors in looped water distribution networks
Authors: Piazza Stefania , Sambito Mariacrocetta , Freni Gabriele 
Published: April 2022

Abstract
To develop an efficient monitoring system for looped piped water systems, an adequate model for evaluating water quality is necessary. Several literature studies have used advective-reactive models to analyse water quality, neglecting diffusive transport, which is claimed to be irrelevant in turbulent flows. Although this may be true in simple systems such as linear transport pipes, the presence of laminar flows in looped systems may be significant, especially at night and in the peripheral parts of the network. The present paper compares the current EPANET advective model, an updated version of EPANET in which diffusion-dispersion equations were implemented and a newly developed diffusive-dispersive model under dynamic conditions that uses the random walk method. The results demonstrated the inadequacy of the advective model in reproducing data from the experimental campaign. Additionally, a significant difference in sensor positioning was found based on the numerical model used.
Mass-based hybrid nanofluid algorithm for entropy generation analysis of flow adjacent to a warmed and down-pointing rotating vertical cone
Authors: Dinarvand Saeed , Berrehal Hamza , Khan Ilyas , Andualem Mulugeta 
Published: April 2022

Abstract
In the present study, the flow, heat transfer, and entropy generation of aqueous copper oxide-silver hybrid nanofluid over a down-pointing rotating vertical cone in the presence of a cross magnetic field has been investigated numerically. The modeling is done by using of the mass-based algorithm and the entropy generation analysis will be implemented in combination with the mentioned model. Five shapes of nanoparticle including the sphere, brick, cylinder, platelet, and disk as well as two types of boundary conditions containing the linear surface temperature (LST) and linear surface heat flux (LSHF) have been considered to present a collection of critical results. The governing PDEs are converted to the dimensionless ODEs using the similarity transformation method and the simplified ODEs are solved numerically by Runge–Kutta–Fehlberg approach coupled with a shooting procedure for some values of the emerged parameters. After achieving the excellent agreement of the computational results with previous reports, the results are presented for the behavior analysis of the hydrodynamics/thermal boundary layers, the skin friction and Nusselt number as well as entropy generation and Bejan number. The highest Nusselt number has been computed for a state of hybrid nanofluid, which shows a remarkable heat transfer augmentation relative to the states of mono-nanofluid and regular fluid; however, the skin friction values always should be considered and controlled. The entropy generation number enhances with the mass of the second nanoparticle (silver), while the reverse trend is demonstrated for the Bejan number. Further, the lowest value of entropy generation number belongs to the cylindrical shape of nanoparticles in the LST case. Consequently, reliable treatment of the mass-based algorithm for the entropy analysis is a substantial achievement of the present research.