bluuebunny/crossref_metadata_2025_split huggingface dataset:
Alexa, know your limits: developing a framework for the accepted and desired degree of product smartness for digital voice assistants
Authors: Graf Erika , Zessinger Denise 
Published: May 2022

AbstractThis research investigates the conditions for the acceptance of digital voice user interfaces focusing on the accepted and desired degree of product smartness. We argue that digital voice assistants (DVAs) are different from other smart products because DVAs are not self-contained products. Smart products also work without DVAs. Therefore, the decision to buy and use a DVA is different. DVAs are not designed to work in isolation. Of course, they can be used only to talk to, but that greatly restricts what the assistants are capable of. The existing literature lacks research on the critical characteristics and properties of DVAs, as well as a categorization of their smartness in the light of the advances in artificial intelligence. The qualitative research design is based on interviews with users and non-users of DVAs. Using a qualitative content analysis, a category system for the degree of product smartness (PS) of DVAs is developed. This paper contributes to the existing literature by exploring the attributes that influence the perception of DVAs and providing a graduated framework for organizing the accepted and desired degree of smartness for DVAs. The framework suggests four gradations each representing an advanced application of artificial intelligence. Red lines appear for some applications, indicating that they are technically feasible but, at least currently, rejected. Rejection relates to the device’s autonomous decision-making and privacy control capabilities, as well as the style of interaction, when the DVA acts as though it was a friend. Future research should quantitatively investigate the relationships between user profiles and acceptance. For designers, the model provides guidance for offering user-customized settings for DVAs, according to user preferences.
Assessing the Potential of Water Reuse Uptake Through a Private–Public Partnership: a Practitioner’s Perspective
Authors: Georgiou Isabella , Caucci Serena , Morris Jonathan Clive , Guenther Edeltraud , Krebs Peter 
Published: May 2022

AbstractAround 20% of the global water abstractions are originated by the industrial sector, while water demand overall will increase by 20–33% by 2050. Wastewater could provide an alternative source of water for industrial activities. There are not many studies exploring the potential of treated wastewater use under a private–public partnership (PPP), despite their potential of contributing to an effective integrated water management through the creation of inter-sectorial synergies. This paper aims therefore to provide a holistic overview of the main factors that affect the effectiveness of PPPs in using treated municipal wastewater in the industrial sector. Through a systematic literature review, the main barriers, drivers, industries and different applications of water use are analysed. Barriers and drivers are classified through the inductive Gioia method into seven categories. The results showed that economic and technical aspects related to the feasibility of the scheme were most prominent in the literature, while water availability seems to be central driving factor for such water reuse schemes. The conclusion of PPPs in water reuse, however, relies on the possibilities for such a partnership and on bridging the needs of the two parties, which entails effective communication through negotiation and information sharing. This paper is a first step to understanding how water circularity practices under an interconnected and sustainable urban environment can be facilitated and explored.
The cost and cost efficiency of conducting a 24-h dietary recall using INDDEX24, a mobile dietary assessment platform, compared with pen-and-paper interview in Viet Nam and Burkina Faso
Authors: Adams Katherine P. , Bell Winnie , Somé Jérome W. , Colaiezzi Brooke , Wafa Sarah , Rogers Beatrice , Coates Jennifer 
Published: May 2022

AbstractThe INDDEX24 Dietary Assessment Platform (INDDEX24) was developed to facilitate the collection of 24-h dietary recall (24HR) data. Alongside validation studies in Viet Nam and Burkina Faso in 2019–2020, we conducted activity-based costing studies to estimate the cost of conducting a 24HR among women of reproductive age using INDDEX24 compared with the pen-and-paper interview (PAPI) approach. We also modelled alternative scenarios in which: (1) 25–75 % of dietary reference data were borrowed from the INDDEX24 Global Food Matters Database (FMDB); (2) all study personnel were locally based and (3) national-scale surveys. In the primary analysis, in Viet Nam, the 24HR cost US $111 004 ($755/respondent, n 147) using INDDEX24 and $120 483 ($820/respondent, n 147) using PAPI. In Burkina Faso, the 24HR cost $78 105 ($539/respondent, n 145) using INDDEX24 and $79 465 ($544/respondent, n 146) using PAPI. In modelled scenarios, borrowing dietary reference data from the FMDB decreased the cost of INDDEX24 by 17–34 % (Viet Nam) and 5–15 % (Burkina Faso). With all locally based personnel, INDDEX24 cost more than PAPI ($498 v. $448 per respondent in Viet Nam and $456 v. $410 in Burkina Faso). However, at national scales (n 4376, Viet Nam; n 6500, Burkina Faso) using all locally based personnel, INDDEX24 was more cost-efficient ($109 v. $137 per respondent in Viet Nam and $123 v. $148 in Burkina Faso). In two countries and under most circumstances, INDDEX24 was less expensive than PAPI. Higher INDDEX24 survey preparation costs (including purchasing equipment) were more than offset by higher PAPI data entry, cleaning and processing costs. INDDEX24 may facilitate cost-efficient dietary data collection.
Higher rank motivic Donaldson–Thomas invariants of via wall-crossing, and asymptotics
Authors: CAZZANIGA ALBERTO , RALAIVAOSAONA DIMBINAINA , RICOLFI ANDREA T. 
Published: May 2022

AbstractWe compute, via motivic wall-crossing, the generating function of virtual motives of the Quot scheme of points on
${\mathbb{A}}^3$
, generalising to higher rank a result of Behrend–Bryan–Szendrői. We show that this motivic partition function converges to a Gaussian distribution, extending a result of Morrison.
Loyalty and Competence: The Political Selection of Local Cadres in China
Authors: Jia Linan 
Published: May 2022

AbstractScholarly debate on the role of various contributing factors in cadre promotion yields conflicting evidence for different administrative levels in China, yet rarely has any quantitative evidence been presented for below the county level. This study explores the causal relationship between loyalty, competence and promotion at the township level. Based on an original dataset of local cadre training records, this paper utilizes cadres’ training experience at Party schools and academic institutions to account for loyalty and competence at the local level. Using a rigorous data-preprocessing method – coarsened exact matching (CEM) – this paper explores the causal effects of cadre training on promotion. The empirical results show that Party school training significantly increases the probability of promotion for township-level cadres, while university training contributes to chances of promotion to a lesser but indispensable degree. Moreover, local cadres who are both Party school and university trained enjoy the best chances of promotion.
Scurrying seafarers: shipboard rats, plague, and the land/sea border
Authors: Skotnes-Brown Jules 
Published: May 2022

AbstractThis paper provides a broad overview of spatial, architectural, and sensory relationships between rats and humans on British and American vessels from approximately the 1850s–1950s. Taking rats as my primary historical actors, I show how humans attempted to prevent the movement of these animals between ports across three periods. Firstly, the mid- to- late-nineteenth century, where few attempts were made to prevent rats from boarding ships, and where a multiplicity of human/rat relationships can be located. Secondly, the 1890s–1920s, in which port authorities erected anti-rat borders to lock these animals on land or at sea. Finally, the 1920s–50s, where ships were reconstructed to eliminate all possibilities of rodent inhabitation and to interrupt their transit between ports. Ship rats, I argue, not only demonstrate the fragility of historical rodent-control efforts, but also encourage oceanic historians to consider how animals have negotiated and shaped boundaries between spheres of land and sea.
Capture and express, question and understand: Gloves in gestural electronic music performance
Authors: Schacher Jan 
Published: May 2022

AbstractGesture-based musical performance with on-body sensing represents a particular case of wearable connection. Gloves and hand-sensing interfaces connected to real-time digital sound production and transformation processes enable empty-handed, expressive musical performance styles. In this article, the origins and developments of this practice as well as a specific use case are investigated. By taking the technical, cognitive, and cultural dimensions of this media performance as foundation, a reflection on the value, limitations, and opportunities of computational approaches to movement translation and analysis is carried out. The insights uncover how the multilayered, complex artistic situations produced by these performances are rich in intersections and represent potent amplifiers for investigating corporeal presence and affective engagement. This allows to identify problems and opportunities of existing research approaches and core issues to be solved in the domain of movement, music, interaction technology, and performance research.
The Diurnal Path to Persistent Convective Self‐Aggregation
Authors: Jensen Gorm G. , Fiévet Romain , Haerter Jan O. 
Published: May 2022

AbstractClustering of tropical thunderstorms constitutes an important climate feedback because it influences the radiative balance. Convective self‐aggregation (CSA) is a profound modeling paradigm for explaining the clustering of tropical oceanic thunderstorms. However, CSA is hampered in the realistic limit of fine model resolution when cold pools—dense air masses beneath thunderstorm clouds—are well‐resolved. Studies on CSA usually assume the surface temperature to be constant, despite realistic surface temperatures varying significantly between night and day. Here we mimic the diurnal cycle in cloud‐resolving numerical experiments by prescribing a surface temperature oscillation. Our simulations show that the diurnal cycle enables CSA at fine resolutions, and that the process is even accelerated by finer resolutions. We attribute these findings to vigorous combined cold pools emerging in symbiosis with mesoscale convective systems. Such cold pools suppress buoyancy in extended regions (∼100 km) and enable the formation of persistent dry patches. Our findings help clarify how the tropical cloud field forms sustained clusters under the diurnal forcing and may have implications for the origin of extreme thunderstorm rainfall and tropical cyclones.
Evaluating Spatial and Temporal Dynamics of River‐Floodplain Surface Water Connectivity Using Hydrometric, Geochemical and Microbial Indicators
Authors: Brooks Alexander C. , Covino Tim , Hall Ed K. 
Published: May 2022

AbstractWater‐mediated linkages that connect landscape components are collectively referred to as hydrologic connectivity. In river‐floodplain systems, quantifying hydrologic connectivity is challenging yet enables descriptions of hydrologic function that emerge from complex, heterogeneous interactions of underlying geomorphic, climatic and biologic controls. Here, we quantify surface water hydrologic connectivity using field indicators and develop a connectivity strength metric across a river‐floodplain system. To measure connectivity strength, we analyzed hydrometric data, conservative tracers, and natural occurring geochemical and microbial tracers across streamflows. We developed empirical models of hydrologic connectivity and predicted daily connectivity strength values across sites and assessed the sensitivity of connectivity to streamflow variability. Some floodplain areas were consistently connected or disconnected to the river, while other floodplain areas exhibited variable connectivity strength through the season. Of the locations with intermittent connectivity, some disconnected quickly and others had a prolonged disconnection phase. At the river‐floodplain system scale, we found hydrologic connectivity always increased with streamflow while across‐system variance in connectivity peaked at intermediate streamflow. Floodplain locations with intermittent surface connectivity demonstrated inter‐annual variability in hydrologic connectivity as a function of climate variability. Our results suggest that intermediate flows are critical periods for seasonal connectivity regimes and understanding the influence of changing climate on full flow durations will be required to predict impacts on river‐floodplain connectivity.
Hypertension treatment cascade in India: results from National Noncommunicable Disease Monitoring Survey
Authors: Amarchand Ritvik , Kulothungan Vaitheeswaran , Krishnan Anand , Mathur Prashant 
Published: May 2022

AbstractHypertension is a major risk factor for ischemic heart disease and stroke. We estimated prevalence, awareness, treatment, and control of hypertension along with its determinants in India. We used data from the National NCD Monitoring Survey-(NNMS-2017-2018) which studied one adult (18–69 years) from a representative sample of households across India and collected information on socio-demographic variables, risk factors for NCDs and treatment practices. Blood pressure was recorded digitally and hypertension was defined as systolic blood pressure (SBP) ≥ 140 mmHg or diastolic blood pressure (DBP) ≥ 90 mmHg or currently on medications. Awareness was defined as being previously diagnosed with hypertension by a health professional; on treatment as taking a dose of medication once in the last 14 days and; control as SBP < 140 mmHg and DBP < 90 mmHg. Multivariate Logistic regression was performed to estimate determinants. Out of 10,593 adults with a blood pressure measurement (99.4%), 3017 (28.5%; 95% CI: 27.0–30.1) were found to have hypertension. Of these hypertensives, 840 (27.9%; 95% CI: 25.5–30.3) were aware, 438 (14.5%; 95% CI: 12.7–16.5) were under treatment and, 379 (12.6%; 95% CI: 11.0–14.3) were controlled. Significant determinants of awareness were being in the age group 50–69 years (aOR 2.45 95% CI: 1.63–3.69), women (1.63; 95% CI: 1.20–2.22) and from higher wealth quintiles. Those in the age group 50–69 (aOR 4.80; 95% CI: 1.74–13.27) were more likely to be under treatment. Hypertension control was poorer among urban participants (aOR 0.55; 95% CI: 0.33–0.90). Significant regional differences were noted, though without any clear trend. One-fifth of the patients were being managed at public facilities. The poor population-level hypertension control needs strengthening of hypertension services in the Universal Health Coverage package.
SAPAP3 regulates epileptic seizures involving GluN2A in post-synaptic densities
Authors: Zhang Yanke , Wu Junhong , Yan Yin , Gu Yixue , Ma Yuanlin , Wang Min , Zhang Hui , Tao Kaiyan , Lü Yang , Yu Weihua , Jing Wei , Wang Xuefeng , Tian Xin 
Published: May 2022

AbstractAberrantly synchronized neuronal discharges in the brain lead to epilepsy, a devastating neurological disease whose pathogenesis and mechanism are unclear. SAPAP3, a cytoskeletal protein expressed at high levels in the postsynaptic density (PSD) of excitatory synapses, has been well studied in the striatum, but the role of SAPAP3 in epilepsy remains elusive. In this study, we sought to investigate the molecular, cellular, electrophysiological and behavioral consequences of SAPAP3 perturbations in the mouse hippocampus. We identified a significant increase in the SAPAP3 levels in patients with temporal lobe epilepsy (TLE) and in mouse models of epilepsy. In addition, behavioral studies showed that the downregulation of SAPAP3 by shRNA decreased the seizure severity and that the overexpression of SAPAP3 by recombinant SAPAP3 yielded the opposite effect. Moreover, SAPAP3 affected action potentials (APs), miniature excitatory postsynaptic currents (mEPSCs) and N-methyl-D-aspartate receptor (NMDAR)-mediated currents in the CA1 region, which indicated that SAPAP3 plays an important role in excitatory synaptic transmission. Additionally, the levels of the GluN2A protein, which is involved in synaptic function, were perturbed in the hippocampal PSD, and this perturbation was accompanied by ultrastructural morphological changes. These results revealed a previously unknown function of SAPAP3 in epileptogenesis and showed that SAPAP3 may represent a novel target for the treatment of epilepsy.
RNA-binding protein MEX3D promotes cervical carcinoma tumorigenesis by destabilizing TSC22D1 mRNA
Authors: Zheng Zhi , Chen Xiaojing , Cai Xiaoyun , Lin Hui , Xu Junfen , Cheng Xiaodong 
Published: May 2022

AbstractRNA-binding proteins (RBPs) have been related to cancer development. Their functions in cervical cancer, however, are virtually unknown. One of these proteins, Mex-3 RNA-binding family member D (MEX3D), has been recently found to exhibit oncogenic properties in a variety of cancer types. In this present study, the functional roles and the regulatory mechanisms underlying MEX3D were examined in cervical cancer. The detection of MEX3D mRNA expression levels in cervical tissues was performed using reverse transcription-quantitative PCR. For functional analysis, for detecting apoptosis and cell proliferation in cervical cancer cells, the Cell Counting Kit-8, colony formation, and flow cytometry were utilized (SiHa and CaSki). The potential mechanisms of MEX3D were assessed and elucidated utilizing western blot analysis, RNA pull-down, RNA immunoprecipitation, and mRNA stability assays. For verification of MEX3D role in vivo, mouse xenograft models were established. When compared to normal cervical tissues, MEX3D expression was observed to be higher in cervical cancer tissues. MEX3D expression was increased in human papillomavirus (HPV) 16 positive cervical cancer tissues and positively regulated by HPV16 E7. When MEX3D expression was knocked down in cervical cancer cells, cell proliferation was decreased, colony formation was inhibited, and apoptosis was promoted. Furthermore, in a mouse xenograft model, knocking down MEX3D expression reduced cervical cancer tumor growth. In addition, MEX3D acted as an RBP to reduce TSC22 domain family protein 1 (TSC22D1) mRNA stability by directly binding to TSC22D1 mRNA. The findings revealed that MEX3D is upregulated by HPV16 E7 and has a crucial oncogenic in cervical cancer development via sponging TSC22D1 for destabilizing its mRNA levels. According to the findings of this study, MEX3D may be a potential therapeutic target for treating cervical cancer patients.
HIV- 1 lentivirus tethering to the genome is associated with transcription factor binding sites found in genes that favour virus survival
Authors: Suleman Saqlain , Payne Annette , Bowden Johnathan , Haque Sharmin Al , Zahn Marco , Fawaz Serena , Khalifa Mohammad S. , Jobling Susan , Hay David , Franco Matteo , Fronza Raffaele , Wang Wei , Strobel-Freidekind Olga , Deichmann Annette , Takeuchi Yasuhiro , Waddington Simon N. , Gil-Farina Irene , Schmidt Manfred , Themis Michael 
Published: May 2022

AbstractLentiviral vectors (LV) are attractive for permanent and effective gene therapy. However, integration into the host genome can cause insertional mutagenesis highlighting the importance of understanding of LV integration. Insertion site (IS) tethering is believed to involve cellular proteins such as PSIP1/LEDGF/p75, which binds to the virus pre-integration complexes (PICs) helping to target the virus genome. Transcription factors (TF) that bind both the vector LTR and host genome are also suspected influential to this. To determine the role of TF in the tethering process, we mapped predicted transcription factor binding sites (pTFBS) near to IS chosen by HIV-1 LV using a narrow 20 bp window in infected human induced pluripotent stem cells (iPSCs) and their hepatocyte-like cell (HLC) derivatives. We then aligned the pTFBS with these sequences found in the LTRs of native and self-inactivated LTRs. We found significant enrichment of these sequences for pTFBS essential to HIV-1 life cycle and virus survival. These same sites also appear in HIV-1 patient IS and in mice infected with HIV-1 based LV. This in silco data analysis suggests pTFBS present in the virus LTR and IS sites selected by HIV-1 LV are important to virus survival and propagation.
Nano-crumples induced Sn-Bi bimetallic interface pattern with moderate electron bank for highly efficient CO2 electroreduction
Authors: Ren Bohua , Wen Guobin , Gao Rui , Luo Dan , Zhang Zhen , Qiu Weibin , Ma Qianyi , Wang Xin , Cui Yi , Ricardez–Sandoval Luis , Yu Aiping , Chen Zhongwei 
Published: May 2022

AbstractCO2 electroreduction reaction offers an attractive approach to global carbon neutrality. Industrial CO2 electrolysis towards formate requires stepped-up current densities, which is limited by the difficulty of precisely reconciling the competing intermediates (COOH* and HCOO*). Herein, nano-crumples induced Sn-Bi bimetallic interface-rich materials are in situ designed by tailored electrodeposition under CO2 electrolysis conditions, significantly expediting formate production. Compared with Sn-Bi bulk alloy and pure Sn, this Sn-Bi interface pattern delivers optimum upshift of Sn p-band center, accordingly the moderate valence electron depletion, which leads to weakened Sn-C hybridization of competing COOH* and suitable Sn-O hybridization of HCOO*. Superior partial current density up to 140 mA/cm2 for formate is achieved. High Faradaic efficiency (>90%) is maintained at a wide potential window with a durability of 160 h. In this work, we elevate the interface design of highly active and stable materials for efficient CO2 electroreduction.
Natural transformation allows transfer of SCCmec-mediated methicillin resistance in Staphylococcus aureus biofilms
Authors: Maree Mais , Thi Nguyen Le Thuy , Ohniwa Ryosuke L. , Higashide Masato , Msadek Tarek , Morikawa Kazuya 
Published: May 2022

AbstractSCCmec is a large mobile genetic element that includes the mecA gene and confers resistance to β-lactam antibiotics in methicillin-resistant Staphylococcus aureus (MRSA). There is evidence that SCCmec disseminates among staphylococci, but the transfer mechanisms are unclear. Here, we show that two-component systems mediate the upregulation of natural competence genes in S. aureus under biofilm growth conditions, and this enhances the efficiency of natural transformation. We observe SCCmec transfer via natural transformation from MRSA, and from methicillin-resistant coagulase-negative staphylococci, to methicillin-sensitive S. aureus. The process requires the SCCmec recombinase genes ccrAB, and the stability of the transferred SCCmec varies depending on SCCmec types and recipients. Our results suggest that natural transformation plays a role in the transfer of SCCmec and possibly other mobile genetic elements in S. aureus biofilms.