bluuebunny/crossref_metadata_2025_split huggingface dataset:
Short-Term Epileptic Seizures Prediction based on Cepstrum Analysis and Signal Morphology
Authors: Tajadini Bahar , Nejad Saeid Reza Seyd , Rezakhani Soheila 
Published: May 2022

Abstract
This article aims to provide and implement apatient-specific seizure (for Intervention Time (IT) detection)prediction algorithm using non-invasive data to develop warningdevices to prevent further patient injury and reduce stress.Employing algorithms with high initial data volume and computationstime to increase the accuracy is an important problem inprediction issues. Consequently, reduction of calculations is metby applying only two effective EEG signal channels without manualremoval of artifacts by visual inspection as the algorithm’sinput. AR modeling and Cepstrum detect changes due to ITperiod. We carry out the goal of higher accuracy by increasingsensitivity to interictal epileptiform discharges or artifacts andreduce errors caused by them, taking advantage of the discretewavelet transform and the comparison of two channels epochsby applying the median filter. Averaging and positive envelopemethods are introduced to patient-specific thresholds becomemore differentiated as soon as possible and can be lead to soonerprediction. We examined this method on a mathematical modelof adult epilepsy as well as on 10 patients with EEG data.The results of our experiments confirm that performance of theproposed approach in accuracy and average false prediction rateis superior to other algorithms. Simulation results have beenshown the robustness of our proposed method to artifacts anderrors, which is a step towards the development of real-timealarm devices by non-invasive techniques.
Spatial clusters of type 2 diabetes and their individual and neighborhood socioeconomic characteristics among participants of the ELSA-Brasil Cohort
Authors: de Oliveira Fernando Luiz Pereira , Pimenta Adriano Marçal , Duncan Bruce Bartholow , Griep Rosane Harter , Souza Gustavo , Barreto Sandhi Maria , Giatti Luana 
Published: May 2022

Abstract
Background: This study identified spatial clusters of T2DM among participants of the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil) residing in two cities, and verified individual and neighborhood socioeconomic environmental characteristics associated with spatial clusters of T2DM. Methods: A cross-sectional study, conducted with 4,335 participants in ELSA-Brasil (2,486 from the city of Belo Horizonte; 1,849 from the city of Salvador), using baseline data collected from 2008 to 2010. T2DM was defined as fasting glycaemia ≥ 126 mg/dL (7.0 mmol/L), or oral glucose tolerance test ≥ 200 mg/dL (11.1 mmol/L), or glycated hemoglobin ≥ 6.5% (48 mmol/L); or by antidiabetic drug use; or by the self-reported medical diagnosis of T2DM. The neighborhood socioeconomic characteristics were obtained from the Brazilian census 2011. The levels per geographic area were defined punctually according to the individual’s place of residence. A spatial data analysis was conducted with the SaTScanTM method to detect the T2DM cluster areas. This study also analyzed the individual and neighborhood socioeconomic characteristics of participants living inside and outside of identified T2DM clusters, using the hierarchical logistic regression model. Results: A total of 336 and 343 participants had T2DM in Belo Horizonte (prevalence = 13.5%) and Salvador (prevalence = 18.5%), respectively. Two cluster areas showing a high chance of T2DM were identified in the Northeastern region of Belo Horizonte and the Northern region of Salvador. In the latter city, a cluster area of low chance of T2DM was also identified, located in the Southern region. In both cities, participants living in the high T2DM cluster area were more likely to report brown or black skin color, a low level of education, and a manual work occupation; these were also considered to be low income areas. By contrast, participants in the low T2DM cluster area of Salvador were less likely to be black and to have university degrees; this was considered to be a high income area. Conclusion: More vulnerable individual and neighborhood socioeconomic characteristics were associated with living in clusters of higher occurrence of T2DM, while better individual and contextual profiles were associated with clusters of a lower prevalence of T2DM.
Analysis of influencing factors for prognosis of patients with ventricular septal perforation: a single-center retrospective study
Authors: Duan Ming-Xuan , Zhao Xi , Li Shao-Lin , Tao Jun-Zhong , Yue Zhen-Zhen , Zhao Xiao-Yan 
Published: May 2022

Abstract
Background: Ventricular septal rupture (VSR) is a serious and fatal mechanical complication of acute myocardial infarction (AMI), once AMI patients are complicated with VSR, the mortality rate is as high as 90%. In this study, we explored the factors affecting the long-term prognosis of VSR patients from many aspects, and evaluated the evaluation performance of multiple scoring systems such as European Heart Surgery Risk Assessment System II (EuroSCORE II). Methods: This study retrospectively enrolled 188 patients with VSR between Dec 9, 2011 and Nov 21, 2021at First Affiliated Hospital of Zhengzhou University. All patients were followed up until Jan 27, 2022 for clinical data, angiographic characteristics, echocardiogram outcomes, intraoperative, postoperative characteristics and major adverse cardiac events (MACEs) (30-day mortality, all-cause readmissions, recurrent MI, and unstable angina). Cox proportional hazard regression analysis was used to explore the predictors of long-term mortality. Results: The median age of 188 VSR patients was 66.2±9.1 years and 97 (51.6%) were males. And there were 103 (54.8%) patients in the medication group, 34 (18.1%) patients in the percutaneous TCC group, and 51 (27.1%) patients in the surgical repair group. The average follow-up time was 857.4 days. The long-term mortality of the medically managed group, percutaneous TCC group, and surgical management group was 94.2, 32.4, and 35.3%, respectively. Whether combined with cardiogenic shock (OR 0.023, 95% CI 0.001–0.054, p=0.019), NT-pro BNP level (OR 0.027, 95% CI 0.002–0.34, p=0.005), EuroSCORE II (OR 0.530, 95% CI 0.305–0.918, p=0.024) and therapy group (OR 3.518, 95% CI 1.079–11.463, p=0.037) were independently associated with long-term mortality in patients with VSR. The cutoff point of EuroSCORE II was determined to be 14, and there were statistically significant differences between EuroSCORE II ＜ 14 group and EuroSCORE II≥14 group (HR=0.2596, 95%CI: 0.1800-0.3744, Logrank P＜ 0.001). Conclusions: The prognosis of VSR patients without operative management remains poor, more research is needed to determine the optimal timing of surgery in patients with VSR to improve clinical outcomes. Moreover, EuroSCORE II could be used as a prognostic factor for VSR patients.
Senescence-Accelerated Mice Prone 8 (SAMP8) in male as a spontaneous osteoarthritis model
Authors: Sanada Yohei , Ikuta Yasunari , Ding Chenyang , Shinohara Masahiro , Yimiti Dilimulati , Ishitobi Hiroyuki , Nagira Keita , Lee Minjung , Akimoto Takayuki , Shibata Sachi , Ishikawa Masakazu , Nakasa Tomoyuki , Matsubara Kiminori , Lotz Martin , Adachi Nobuo , Miyaki Shigeru 
Published: May 2022

Abstract
Background: Animal models of spontaneous osteoarthritis (OA) are sparse and not well characterized. The purpose of the present study is to examine OA-related changes and mechanisms in senescence-accelerated mouse-Prone 8 (SAMP8) that displays a phenotype of accelerated aging. Methods: Knees of male SAMP8 and SAM-resistant 1 (SAMR1) mice as control from 6 to 33 weeks of age were evaluated by histological grading systems for joint tissues (cartilage, meniscus, synovium and subchondral bone), and µCT analysis. Gene expression patterns in articular cartilage were analyzed by real-time PCR. Immunohistochemistry was performed for OA-related factors, senescence markers and apoptosis. Results: Starting at 14 weeks of age, SAMP8 exhibited mild OA-like changes such as proteoglycan loss and cartilage fibrillation. From 18 to 33 weeks of age, SAMP8 progressed to partial or full-thickness defects with exposure of subchondral bone on the medial tibia and exhibited synovitis. Histological scoring indicated significantly more severe OA in SAMP8 compared with SAMR1 from 14 weeks [median (interquartile range):　SAMR1:0.89 (0.56-1.81) vs SAMP8:1.78 (1.35-4.62)] to 33 weeks of age [SAMR1:1.67 (1.61-1.04) vs SAMP8:13.03 (12.26-13.57)]. Subchondral bone sclerosis in the medial tibia, bone mineral density (BMD) loss of femoral metaphysis and meniscus degeneration occurred much earlier than the onset of cartilage degeneration in SAMP8 at 14 weeks of age. Conclusions: SAMP8 are a spontaneous OA model that is useful for investigating the pathogenesis of primary OA and evaluating therapeutic interventions.
The interactive dynamics of a binary asteroid and ejecta after medium kinetic impact
Authors: Gao Yunfeng , Cheng Bin , Yu Yang 
Published: May 2022

Abstract
Kinetic impacts on a binary asteroid will produce ejecta debris as well as causing a disturbance to the spin-orbit motion of the binary components. Understanding the complex interactions between the ejecta and the binary system can be crucial to both theoretical study and mission design. In this paper, we develop a detailed model for the dynamical evolution of ejecta within a binary asteroid system, in which we combined various perturbations on the ejecta and considered the collisional process with the asteroid. Taking an example scenario like the DART impact, we calculated the fate of ejecta from size 0.01 mm to 10 m and analyzed the distribution of their final deposition locations. The results show that ejecta with diameter less than 0.1 mm escape quickily under the influence of solar radiation pressure, while ejecta of larger size survive longer, i.e., a few cycles in the binary system for more than 400 days. We analyzed the influence of the coefficient of restitution between ejecta and asteroid, and found more damped collisions would allow the ejecta to survive longer in orbit. We also studied the effect of the tumbling rotation of the secondary on the distribution of ejecta on the surface of the secondary, the results suggest that a tumbling rotational state causes obvious changes in Dimorphos' surface slope, which, however, are not sufficient for triggering surface landslides. In addition, the influence of the internal structure of the primary on the evolution of the ejecta is studied, and we show it has little effect on the evolution of the ejecta but does affect the distribution of ejecta on the surface of the primary. This is due to the change of the distribution of relative acceleration on the surface of the primary, which changes the regions where the ejecta can remain.
The non-volatile electrostatic doping effect in MoTe2 field-effect transistors controlled by hexagonal boron nitride and a metal gate
Authors: Eom Jonghwa , Khan Muhammad Asghar , Khan Muhammad Farooq , Rehman Shania , Patil Harshada , Dastgeer Ghulam , Ko Byung Min 
Published: May 2022

Abstract
The electrical and optical properties of transition metal dichalcogenides (TMDs) can be effectively modulated by tuning their Fermi levels. To develop a carrier-selectable optoelectronic and memory device, we investigated intrinsically p-type MoTe2, which can be changed to n-type by charging a hexagonal boron nitride (h-BN) substrate through the application of a writing voltage using a metal gate under deep ultraviolet light. The n-type part of MoTe2 can be obtained locally using the metal gate pattern, whereas the other parts remain p-type. Furthermore, we can control the transition rate to n-type by applying a different writing voltage (i.e., − 2 to − 10 V), where the n-type characteristics become saturated beyond a certain writing voltage. Thus, MoTe2 was electrostatically doped by a charged h-BN substrate, and it was found that a thicker h-BN substrate was more efficiently photocharged than a thinner one. We also fabricated a p-n diode using a 0.8 nm-thick MoTe2 flake on a 167 nm-thick h-BN substrate, which showed a high rectification ratio of ~ 104. Finally, we demonstrate the fabrication of a non-volatile memory device using a MoTe2 field-effect transistor (FET) on h-BN with a floating metal (Au) gate. Our observations pave the way for expanding the application of TMD-based FETs to non-volatile memory devices, along with optoelectronic applications.
Cloning and Expression Analysis of Seven VvGA2ox Genes in Ovule Development of Seeded and Seedless Grapes (Vitis vinifera)
Authors: Kong Jixiang , Zhao Ting , Liu Bingchen , Li Yan , zhang chaohong 
Published: May 2022

Abstract
The GA2ox proteins in plants play important roles in the regulation of growth and development, involving in the conversion of physiologically active gibberellins to inactive gibberellins. In this study, we identified 13 VvGA2ox genes in a grape genome-wide analysis and performed bioinformatics analysis for these genes. Phylogenetic analysis of VvGA2ox with homologous in Arabidopsis, maize, and peach showed that these protein can be divided into three subfamilies. Gene structure analysis and synteny analysis of GA2ox gene family revealed that VvGA2ox genes have undergone a complex evolutionary process. Gene expression analysis of tissue-specific for seven VvGA2ox genes suggested that these were lower expression in the vigorous growth tissues. Considering that gibberellin can regulate seed development, in order to further determine the influence of VvGA2ox on seed development, seven VvGA2ox genes were performed with qRT-PCR. The expression profiling of VvGA2ox genes in ‘Pinot noir’ and ‘Thompson seedless’ during various stages of seed development revealed that VvGA2ox3c, VvGA2ox4 and VvGA2ox7 may participate in seed-specific regulation. In summary, these results show that VvGA2ox has a significant difference between seedless and seeded varieties, which may be related to seedless traits.
Human intracranial pulsatility during the cardiac cycle: a computational modelling framework
Authors: Causemann Marius , Vinje Vegard , Rognes Marie E. 
Published: May 2022

Abstract
Background: Today's availability of medical imaging and computational resources set the scene for high-fidelity computational modelling of brain biomechanics. The brain and its environment feature a dynamic and complex interplay between the tissue, blood, cerebrospinal fluid (CSF) and interstitial fluid (ISF). Here, we design a computational platform for modelling and simulation of intracranial dynamics, and assess the models' validity in terms of clinically relevant indicators of brain pulsatility. Methods: We develop finite element models of fully coupled cardiac-induced pulsatile CSF flow and tissue motion in the human brain environment. The three-dimensional model geometry is derived from magnetic resonance images (MRI), features a high level of detail including the brain tissue, the ventricular system, and the cranial subarachnoid space (SAS). We model the brain parenchyma at the organ-scale as an elastic medium permeated by an extracellular fluid network and describe flow of CSF in the SAS and ventricles as viscous fluid movement. Representing vascular expansion during the cardiac cycle, a pulsatile net blood flow distributed over the brain parenchyma acts as the driver of motion. Additionally, we investigate the effect of model variations on a set of clinically relevant quantities of interest. Results: Our model predicts a complex interplay between the CSF-filled spaces and poroelastic parenchyma in terms of ICP, CSF flow, and parenchymal displacements. Variations in the ICP are dominated by their temporal amplitude, but with small spatial variations in both the CSF-filled spaces and the parenchyma. Induced by ICP differences, we find substantial ventricular and cranial-spinal CSF flow, some flow in the cranial SAS, and small pulsatile ISF velocities in the brain parenchyma. Moreover, the model predicts a funnel-shaped deformation of parenchymal tissue in dorsal direction at the beginning of the cardiac cycle. Conclusions: Our model accurately depicts the complex interplay of ICP, CSF flow and brain tissue movement and is well-aligned with clinical observations. It offers a qualitative and quantitative platform for detailed investigation of coupled intracranial dynamics and interplay, both under physiological and pathophysiological conditions.
Effective communication for message prioritization in DTN for disaster scenarios
Authors: Rosas Erika , Andrade Orlando , Hidalgo Nicolás 
Published: May 2022

Abstract
When disaster strikes, effective communication is crucial for emergency responses and accessing a victim’s location. Using smartphone-based Delay Tolerant Networks (DTNs) is the prevalent proposed approach to work around network disruptions. One of the challenges in these networks is high-traffic congestion, since buffer limitation produces message drop before they are delivered. In this article, a congestion control strategy using message prioritization is presented for DTNs to increase network resilience facing high message congestion. We measure congestion considering the free space in the buffers of the nodes involved in the routing or by counting the messages deleted from the buffer in a fixed period to improve the availability and immediacy of information for disaster scenarios. We evaluated the proposed strategies using The ONE simula-tor to test different mobility models and communication protocols. Results show that the strategy improved delivery rate, buffer usage, eliminated messages, overhead, and latency for the highest priority messages. The best results were obtained in terms of latency, which fits our disaster scenario since timely information is vital. The trade-offs are a slightly lower average delivery rate and a decrease in the lowest priority message delivery rate.
Sustained Elimination of Iodine Deficiency within the third decade after Compulsory Iodine Supplementation Policy in South of IRAN
Authors: Jeddi Marjan , Habib Ashkan , Salehi Alireza 
Published: May 2022

Abstract
Background: Recently, some studies in Iran have shown mild to moderate iodine levels in the adults and pregnant population despite iodine sufficiency in children. We designed this study to evaluate the urine iodine status and salt intake of adult household of the city of Sadra, Fars province in southern Iran and to assess its possible influencing factors.Method: Participant households for this cross-sectional study were chosen based on randomized cluster sampling. Two subjects over 18 years of age from each household were invited. 92 subjects (24 men, 68 women) were enrolled. Subjects were asked for 24-hour urine collection, examined for thyroid disorders and sent for thyroid ultrasonography and thyroid function tests. Urine samples were tested for iodine, sodium and creatinine levels. Household salt intakes were estimated.Results: Median urine iodine content (UIC) in the population was 175 (IQR: 117 – 250) µg/L and the median salt consumption per person per day was 9.59 (IQR: 7.34 – 14.55) gr. Gender, methods of salt storage, goiter or thyroid nodules, salt added by cooking stage or subclinical hypothyroidism had no effect on UIC while individuals with hypertension and lower education levels had significantly lower iodine levels. UIC had a significant positive correlation with urine sodium and TSH levels and a negative correlation with thyroid volume and T4. Conclusion: Iodine status in the adult population of city of Sadra is categorized as sufficient despite inadequate iodine levels in Tehran. Contributing factor can be the higher use of salt or possible high environmental iodine concentrations in Sadra.
Obstructive sleep apnea severity is associated with decreased bone mineral density in patients with type 2 diabetes: a retrospective study
Authors: Chen Qingshi , chen zhiyu , Cai Donglu , Chen Yanfeng , Liu dexin 
Published: May 2022

Abstract
BackgroundThere is currently no literature detailing whether diabetes mellitus (DM) combined with obstructive sleep apnea (OSA) accelerates the loss of bone mineral density (BMD). This study, therefore, aimed to explore the association between the severity of respiratory disorders and decreased BMD in T2DM patients with OSA.MethodsA total of 144 T2DM patients were evaluated between 2013 and 2021. Among them, 69 patients with combined T2DM and OSA were selected as the case group, while the other 75 were chosen as the control group. OSA was diagnosed making use of polysomnography (PSG), with its severity evaluated by an apnea hypopnea index (pAHI). Lumbar spine and femoral neck (FN) BMD, and hip geometry parameters were measured using dual-energy X-ray absorptiometry (DXA). Serum HbA1c levels were surveyed using a glucometer. Analysis of variance (ANOVA) and multivariate ANOVA was used for studies.ResultsLow BMD and osteoporosis were prevalent in 59.4% of the patients. Univariate analysis revealed that increasing age was significantly correlated with decreasing lumbar bone mineral density (P < 0.05). The prevalence of low BMD and osteoporosis, as indicated by femoral and lumbar spine BMD and hip geometry parameters, was increased remarkably in the severe OSA group than in the mild and moderate OSA groups (P < 0.05). The hip joint geometry parameters found to be significant in the one-way ANOVA were not significant in the multiple regression analysis.ConclusionOSA severity is significantly associated with a change in the incidence of diabetics with osteoporosis. Our results, together with the strong existing evidence, suggest that close attention should be paid to BMD in T2DM patients with OSA.Clinical Trial RegistrationchiCTR2100048363
Morphology and phylogeny of Neokamalomyces indicus—an addition of Septoria-like new genus and species to Mycosphaerellaceae from India
Authors: Yadav Sanjay , Verma Sanjeet Kumar , Singh Raghvendra , Singh Vinay Kumar , Chaurasia Balmukund , Singh Paras Nath , Kumar Shambhu 
Published: May 2022

Abstract
A new hyaline coelomycetous fungus was discovered on living leaves of Ficus benghalensis (Moraceae) is described and illustrated. Morphologically, it is similar to Septoria or Septoria-like genus, but based on cultural characteristics and multigene (LSU-RPB2-ITS) phylogenetic analysis, this strain represents an additional lineage in Mycosphaerellaceae. Hence, a new genus and species as Neokamalomyces indicus is proposed.