bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nocardia farcinica pituitary abscess in an immunocompetent patient: illustrative case
Authors: Scheitler Kristen M. , Bauman Megan M. J. , Carlstrom Lucas P. , Graffeo Christopher S. , Meyer Fredric B. 
Published: October 2022

BACKGROUND
Pituitary abscess is a rare clinical entity, typically precipitated by Staphylococcus, Pseudomonas, or Aspergillus infection. Although Nocardia species–associated central nervous system abscesses have been documented in immunocompromised patients, no case of Nocardia pituitary abscesses has been previously reported.

OBSERVATIONS
A 44-year-old man presented with hemoptysis and was found to have a cavitary right lung nodule, which was presumed histoplasmosis, prompting antifungal treatment. Several months later, he developed panhypopituitarism. Magnetic resonance imaging identified a pituitary mass, which subsequently underwent transsphenoidal endoscopic biopsy. Infectious workup was negative, and the patient was discharged on intravenous ertapenem therapy. Over several months, he developed progressive headaches, and updated imaging confirmed interval enlargement of the mass with new cavernous sinus invasion. He underwent repeat endoscopic biopsy, which yielded positive cultures for Nocardia farcinica and prompted successful treatment with trimethoprim-sulfamethoxazole and linezolid.

LESSONS
The current study highlights a previously unreported clinical entity, the first pituitary abscess attributable to Nocardia sp. or N. farcinica, which arose in a young, immunocompetent individual. Although rare, atypical infections represent an important component in the differential diagnosis for sellar mass lesions.
Presacral mature cystic teratoma associated with Currarino syndrome in an adolescent with androgen insensitivity: illustrative case
Authors: Koskay Grant , Opperman Patrick , Mezzacappa Frank M. , Menousek Joseph , Fuller Megan K. , Fornoff Linden , Surdell Daniel 
Published: October 2022

BACKGROUND
Currarino syndrome is a rare disorder that classically presents with the triad of presacral mass, anorectal malformation, and spinal dysraphism. The presacral mass is typically benign, although malignant transformation is possible. Surgical treatment of the mass and exploration and repair of associated dysraphism are indicated for diagnosis and symptom relief. There are no previous reports of Currarino syndrome in an androgen-insensitive patient.

OBSERVATIONS
A 17-year-old female patient presented with lack of menarche. Physical examination and laboratory investigation identified complete androgen insensitivity. Imaging analysis revealed a presacral mass lesion, and the patient was taken to surgery for resection of the mass and spinal cord untethering. Intraoperative ultrasound revealed a fibrous stalk connecting the thecal sac to the presacral mass, which was disconnected without the need for intrathecal exploration. The presacral mass was then resected, and pathological analysis revealed a mature cystic teratoma. Postoperatively, the patient recovered without neurological or gastrointestinal sequelae.

LESSONS
Diagnosis of incomplete Currarino syndrome may be difficult but can be identified via work-up of other disorders, such as androgen insensitivity. Intraoperative ultrasound is useful for surgical decision making and may obviate the need for intrathecal exploration during repair of dysraphism in the setting of Currarino syndrome.
Program Pengabdian Masyarakat: Workshop Penulisan Artikel Ilmiah
Authors: Waskita Dana , Sulistyaningtyas Tri 
Published: October 2022

Writing scientific papers is still considered a difficult task for some lecturers, even though according to Law Number 14 of 2005 it is one of the obligations of a lecturer. For this reason, the Media and Cultural Literacy Expertise Group conducts scientific article writing workshops to help lecturers express their ideas and research results systematically according to the rules that apply in the publication of scientific papers. This activity was carried out online and offline by involving approximately 30 lecturers of the Al Islam Polytechnic Bandung. This workshop was conducted using various methods: lectures, discussions, and consultations (coaching clinic). The materials include the introduction of scientific papers, techniques for writing scientific articles, strategies to avoid plagiarism and the practice of using digital reference management programs. Evaluation of this activity was carried out using pretest-posttest and filling out a questionnaire. The results of the evaluation showed that most (96.1%) participants considered the material presented according to their needs and all participants (100%) found it very useful and motivated to write scientific articles.

Keywords: scientific articles, writing techniques, hybrid workshop
Studi Yuridis Tentang Jenis Dan Jalur Pendidikan Di Indonesia
Authors: Arif Rembangsupu  , Kadar Budiman  , Bidin  , Puspita  , Muhammad Yunus Rangkuti  
Published: October 2022

Landasan yuridis formal pelaksanaan pendidikan di negara kita adalah Undang-Undang Republik Indonesia No. 20 tahun 2003 tentang Sistem Pendidikan Nasional. Jenis pendidikan dalam satuan pendidikan ada 8 jenis pendidikan yang terdiri dari : 1). Pendidikan umum, 2). Pendidikan Kejuruan, 3). Pendidikan akademik, 4). Pendidikan profesi, 5). Pendidikan vokasi, 6). Pendidikan keagamaan, 7). Pendidikan khusus, 8). Pendidikan kedinasan. Jalur pendidikan adalah wahana yang dilalui peserta didik untuk mengembangkan potensi dirinya dalam suatu proses pendidikan yang sesuai dengan tujuan pendidikan. Jalur pendidikan di Indonesia terdiri atas pendidikan formal, nonformal. Kata jalur yang dimaksud adalah wahana yang dilalui peserta didik untuk mengembangkan potensi diri dalam suatu proses pendidikan. Ketiga jalur tersebut formal, nonformal, dan informal fungsinya saling melengkapi dan memperkaya
Combining SDLC Method and ITIL Framework by Involving Auditors
Authors: Rahmani Hani , Hikmawati Erna 
Published: October 2022

The framework that provides best practice in IT service management is called IT Infrastructure Library (ITIL). The IT service management leads to the management of a service, this service is generated through the system development process. Each system has a different scale, characteristics, requirements, types, and properties but has the same stage in its development, that is by implementing the System Development Life Cycle (SDLC)
Software developers on IT projects must implement SDLC by selecting a particular model process. But many IT development teams do not pay attention to software management frameworks or standards so that they will experience difficulties in planning, reporting work results, monitoring, controlling, etc., especially when all personnel in the team don’t have sufficient experience. It would be better if every software house company and IT Consultant applies the general framework and standardization so that the software development process will be more directed and produced high quality services.
In conducting the SDLC process, an accountant is needed, in this case the auditor who has a role as an information provider in describing business processes in a company activity, the auditor also plays a role as controller that ensuring the system is in accordance with accounting regulations, and accountants also act as checker of the system so that the auditors must involved in the initial design of a system. The application of ITIL in the SDLC process will have an impact on the ease of the auditor in carrying out the duties.
Potential of Garlic Filtrate as An Alternative Anticoagulant for Whole Blood Samples
Authors: Nuswantoro Ari , Berlianti Jessica Ningtyas 
Published: October 2022

Synthetic anticoagulants such as heparin, citric, and ethylenediaminetetraacetic acid (EDTA) are commonly used to prevent blood clots. In contrast, its widespread use in clinical laboratories is still constrained by price, its toxic nature, and its short shelf life. Therefore, an alternative material that is relatively cheap, non-toxic, and easy to obtain and process in a ready-to-use form is needed. Garlic contains allicin and ajoene, which are anti-platelet and anti-thrombogenic. This study’s aim is to explore the potential of garlic filtrate as an alternative anticoagulant. Blood from 16 individuals was used and separated into four groups: non-anticoagulant, 50 μL/mL garlic filtrate, 100 μL/mL garlic filtrate, and 150 μL/mL heparin, for a total of 64 treatments. The Lee and White method showed that non-anticoagulated blood had normal clotting times (mean 8 minutes and 56 seconds), whereas heparin plasma and garlic filtrate plasma had longer clotting times (more than 20 minutes); and this is statistically different based on the ANOVA test with a significance value (p) of 0.000 < 0.05. On spectrophotometric measurements, the levels of calcium ions in heparinized plasma and serum were 8.66 mg/dL and 8.52 mg/dL, respectively, while in garlic plasma filtrate of 50 μL/mL and 100 μL/mL were 4.13 mg/dL and 3.58 mg/dL, respectively; this is also statistically different based on the ANOVA test with a significance value of 0.000 < 0.05. The differences indicate that garlic filtrate can extend clotting time and reduce calcium ions therefore it is worth reviewing as an alternative anticoagulant.
Correlation of left atrial strain with the recurrence of atrial fibrillation after cardioversion
Authors: Arshinova I. A. , Poltavskaya M. G. , Sedov V. P. , Bogdanova A. A. , Suvorov A. Y. , Kuchina A. Y. 
Published: October 2022

Aim. To evaluate the correlation of values of left atrial (LA) strain in patients with atrial fibrillation (AF) who underwent cardioversion (CV) with AF recurrence, hospitalization or death in early and late periods after cardioversion.Material and methods. 85 patients of the University Clinical Hospital No. 1 of Sechenov University were examined: 30 men (35.3 %) and 55 women (64.7 %), the average age was 70 ± 8 years. All patients underwent speckle tracking, the parameters of LA strain and LA stiffness index were determined upon admission to the hospital after CV; after 1, 3, 6 months, a relapse of AF, the fact of hospitalization for cardiovascular reasons, and death were detected.Results. 4 people died during the follow-up, 37 hospitalizations were registered due to a relapse of AF, 7 developed a long-term persistent/permanent form of AF. The predictors associated with the onset of adverse events at the 3rd month were: reduction of the negative peak in the 4-chamber position (risk ratio (HR) 1.26, 95 % confidence interval (CI) 1.05, 1.51; p=0.009), reduction of LA strain in the 4-chamber position (HR 0.85, CI 0.75, 0.96; p=0.007), reduction of positive strain peaks in the 4-chamber (HR 0.44, CI 0.25, 0.77; p<0.001) position. When analyzing the data of the sixth month of observation, the predictors were: reduction of negative strain peak in 4-chamber (HR 1.33, CI 1.05, 1.69, p=0.009) and 2-chamber (HR 1.23, CI 1.01, 1.5; p=0.029) positions, reduction of global longitudinal strain LA (HR 0.83, CI 0.72, 0.95; p=0.004), high left atrial stiffness index (HR 15.3, CI 6.56, 35.9; p<0.001).Conclusion. Evaluation of LA strain parameters during speckle- tracking may be promising in patients with AF after CV, since their decrease correlates well with the risk of adverse events in the long-term periods (3 and 6 months after CV).
Bio-inspired polymer array vapor sensor with dual signals of fluorescence intensity and wavelength shift
Authors: Zhao Zhihao , Ge Yinghao , Xu Lingyun , Sun Xiaohan , Zuo Jing , Wang Zhenglin , Liu Hongyang , Jiang Xiangyu , Wang Dong 
Published: October 2022

Organic vapor sensors based on polymer owing to their tunable molecular structures and designable functions have attracted considerable research interest. However, detecting multiple organic vapors with high accuracy and a low detection limit is still challenging. Herein, inspired by the mammalian olfactory recognition system, organic vapor sensors based on one-dimensional microfilament array structures with a wide range of sensing gases are demonstrated. By introducing aggregation-induced emission (AIE) molecules, sensors possess dual-optical sensing mechanisms of variation in fluorescence intensity and wavelength. By virtue of the synergistic effects of dual signals, superb accuracy and incredibly low detection limit are achieved for identifying analytes. In particular, the polymer/AIE microfilament array can detect acetone vapor down to 0.03% of saturated vapor pressure. In the saturated vapor of acetone, the fluorescence intensity of the sensor arrays was reduced by 53.7%, while the fluorescence wavelength was red-shifted by 21 nm. Combined with the principal component analysis (PCA) algorithm, the polymer/AIE molecular sensor arrays accomplished the classification and identification of acetone, ethanol, methylene chloride, toluene, and benzene. This bioinspired approach with dual sensing signals may broaden practical applications to high-performance gas sensors for precise molecular detection.
Decellularized fennel and dill leaves as possible 3D channel network in GelMA for the development of an in vitro adipose tissue model
Authors: Grilli Francesca , Pitton Matteo , Altomare Lina , Farè Silvia 
Published: October 2022

The development of 3D scaffold-based models would represent a great step forward in cancer research, offering the possibility of predicting the potential in vivo response to targeted anticancer or anti-angiogenic therapies. As regards, 3D in vitro models require proper materials, which faithfully recapitulated extracellular matrix (ECM) properties, adequate cell lines, and an efficient vascular network. The aim of this work is to investigate the possible realization of an in vitro 3D scaffold-based model of adipose tissue, by incorporating decellularized 3D plant structures within the scaffold. In particular, in order to obtain an adipose matrix capable of mimicking the composition of the adipose tissue, methacrylated gelatin (GelMA), UV photo-crosslinkable, was selected. Decellularized fennel, wild fennel and, dill leaves have been incorporated into the GelMA hydrogel before crosslinking, to mimic a 3D channel network. All leaves showed a loss of pigmentation after the decellularization with channel dimensions ranging from 100 to 500 µm up to 3 μm, comparable with those of human microcirculation (5–10 µm). The photo-crosslinking process was not affected by the embedded plant structures in GelMA hydrogels. In fact, the weight variation test, performed on hydrogels with or without decellularized leaves showed a weight loss in the first 96 h, followed by a stability plateau up to 5 weeks. No cytotoxic effects were detected comparing the three prepared GelMA/D-leaf structures; moreover, the ability of the samples to stimulate differentiation of 3T3-L1 preadipocytes in mature adipocytes was investigated, and cells were able to grow and proliferate in the structure, colonizing the entire microenvironment and starting to differentiate. The developed GelMA hydrogels mimicked adipose tissue together with the incorporated plant structures seem to be an adequate solution to ensure an efficient vascular system for a 3D in vitro model. The obtained results showed the potentiality of the innovative proposed approach to mimic the tumoral microenvironment in 3D scaffold-based models.
The relation between SARS-CoV-2 cases in Bahrain and meteorological parameters: 27 months of data
Authors: Alnaser Waheeb E. , Alnaser Naser W. , Almarabheh Amer J. , Al-Ansari Ahmed M. , Al-Aali Hala H. , Ghanem Amjad Z. 
Published: October 2022

Background: There has been a belief in and strong thought about the existence of a relationship between meteorological parameters and the spread of SARS-CoV-2. Many studies have been conducted but with a short period of investigation, i.e., not more than 4 months. Therefore, the relation between 27 months of SARS-CoV-2 recorded data and meteorological parameters is reported. The aim of this study is to use this vast data to examine whether average temperature, average wind speed, and absolute humidity are clearly correlated with the number of infected SARS-CoV-2 cases in Bahrain or not, which may be applicable to countries that have similar topography.Method: The official recorded data of SARS-CoV-2 cases in Bahrain from the first day that SARS-CoV-2 cases were detected (February 24, 2020) until May 18, 2022, along with 4 meteorological parameters (temperature, wind speed, relative humidity, and absolute humidity) were used. The data were analyzed using SPSS where a p-value less than 0.05 was considered as statistically significant.Result: There is a negative significant correlation between new daily cases of SARS-CoV-2 and temperature, T, and absolute humidity, AH, (r = −0.290, −0.317; p &lt; 0.001, respectively). The results also show a positive significant correlation between daily cases of SARS-CoV-2 and wind speed (V) (r = −0.110; p = 0.002). No correlation was found between daily cases of SARS-CoV-2 and relative humidity (r = −0.028; p = 0.429). An empirical relation is reported, allowing the estimation of SARS-CoV-2 cases in Bahrain as a function of three weather parameters: T, AH, and V.
Characterization of polycyclic aromatic hydrocarbons in soil in a coal mining area, East China: Spatial distribution, sources, and carcinogenic risk assessment
Authors: Ren Mengxi , Zheng Liugen , Hu Jie , Chen Xing , Zhang Yanhai , Dong Xianglin , Wei Xiangping , Cheng Hua 
Published: October 2022

The polycyclic aromatic hydrocarbon (PAH) pollution process in mining areas, particularly coal mining areas, has accelerated because of coal chemical production and gangue accumulation. In this study, PHAs concentrations in surface soil was determined via gas chromatography–mass spectrometry. The composition, spatial distribution and sources of PAHs were analyzed, and their potential carcinogenic risks were evaluated.Results showed a wide PAH concentration range (218–1548 ng g−1). The high molecular weight proportion in contaminated areas was significantly higher than in uncontaminated areas. Clear differences in PAH distribution were detected in contaminated areas, with higher concentrations in the soils near an industrial park and coal gangue piles. The results of positive matrix factorization (PMF) in contaminated area revealed that coking, oil and biomass combustion, and vehicle emissions and coal combustion, contributed 31%, 26%, 24%, and 19%, respectively, to the detected PAHs. In contrast with the 10% contribution rate of the coking source in uncontaminated areas. The Monte Carlo method was used to assess the cancer risk to residents in the study areas. The carcinogenic health risk values for adults in the contaminated areas was higher than the safety standard (2.92 × 10−6) prescribed by the United States Environmental Protection Agency at 95% confidence level. Sensitivity analysis showed that the relative exposure duration (ED) and soil surface area of skin exposure were the most significant parameters for adults, and ED and body weight for children. The cancer risk for both adults and children in contaminated areas was five times than that in uncontaminated areas.
Correlation between Hashimoto’s thyroiditis and polycystic ovary syndrome: A systematic review and meta-analysis
Authors: Hu Xiaojie , Chen Yuquan , Shen Yiting , Zhou Siyuan , Fei Wenting , Yang Yuxin , Que Huafa 
Published: October 2022

ObjectiveA growing body of research suggests that patients with polycystic ovary syndrome (PCOS) may be at increased risk of developing Hashimoto’s thyroiditis (HT), and having both conditions can make the condition worse. However, current research views are not uniform. Therefore, to explore the link between PCOS and HT, we conducted this study.MethodsFrom the establishment of the database to August 2022, we searched 2 databases to study the correlation between Hashimoto’s and polycystic ovary syndrome. Two authors independently screened the articles for eligibility, and three authors extracted relevant data. Statistical analysis was performed using STATA16.0 software.ResultsA total of 20 studies were included, including 7 case-control studies and 13 cross-sectional studies. A total of 13 countries and 7857 participants were embraced. Studies have demonstrated that both PCOS patients have an increased risk of HT, and meanwhile, HT patients also have an increased risk of PCOS compared with controls. The study also incorporated that the prevalence of HT in PCOS patients in India and Turkey was higher than in other countries, and the prevalence of HT in PCOS patients in South America was higher than in Asia and Europe.ConclusionsIn conclusion, our study illustrates that there is a correlation between PCOS and HT, and it is necessary to further study the underlying mechanism between PCOS and HT. At the same time, it is of great significance to regularly screen PCOS patients for HT risk and HT patients for PCOS risk.Systematic Review Registrationhttps://www.crd.york.ac.uk/prospero/, identifier CRD 42022351168.
The relationship between urinary iodine concentration and papillary thyroid cancer: A systematic review and meta-analysis
Authors: Zhang Xueqi , Zhang Fan , Li Qiuxian , Aihaiti Renaguli , Feng Chuyao , Chen Deshi , Zhao Xu , Teng Weiping 
Published: October 2022

BackgroundThe effect of iodine on papillary thyroid cancer (PTC) has been controversial for many years. Since urinary iodine is an effective indicator of iodine intake, some recent epidemiological studies have described the relationship between urinary iodine concentration (UIC) and PTC.MethodsWe searched PubMed, Embase, Cochrane Library, and Web of Science for case-control studies about UIC and PTC published before September 2022. Results are presented as the overall odds ratio (OR) and 95% confidence intervals (CI).ResultsAccording to the analysis of the included studies, excessive iodine intake (UIC≥300ug/L) was positively associated with the occurrence of PTC patients compared with healthy controls (OR4.05, 95%CI 1.64-10.02, P=0.002). Meanwhile, adequate iodine exposure (100≤UIC&lt;200ug/L) may play a protective role in the occurrence of PTC compared with healthy individuals (OR 0.36, 95%CI 0.14-0.91, P=0.03) while the difference in the prevalence of insufficient iodine intake (UIC&lt;100ug/L) and iodine above requirements (200≤UIC&lt;300ug/L) among the two groups were not significant (deficiency: OR 0.38, 95%CI 0.13-1.16, P=0.09; above requirements: OR 0.92, 95%CI 0.40-2.10, P=0.84). After comparing the UIC levels of PTC patients with those of other thyroid diseases, we found that there was also no significant difference in the incidence of different levels of UIC in the two groups (excessive: OR 1.25, 95%CI 0.87-1.80, P=0.22; above requirements: OR 0.93, 95%CI 0.77-1.14, P=0.49; adequate: OR 0.96, 95%CI 0.78-1.17, P=0.67; deficiency: OR 1.02, 95%CI 0.86-1.22, P=0.80). The result of this meta-analysis also did not support the relationship between UIC and the BRAF mutation and lymph node metastasis (LNM) of PTC patients. Besides, we also found that studies on the relationship between urinary iodine and PTC may be influenced by the way UIC was measured.ConclusionThe 10 case-control included studies involved a total of 6,544 participants. The results of this meta-analysis showed excessive iodine intake, that is, UIC≥300ug/L was associated with the occurrence of PTC but not with BRAF mutation and LNM while adequate iodine intake (100≤UIC&lt;200ug/L) may be one of the protective factors for PTC.