bluuebunny/crossref_metadata_2025_split huggingface dataset:
Incapacitas assumendi (kan. 1095, n. 3 KPK/83) w wyroku Roty Rzymskiej c. Verginelli z 25 marca 2011 roku
Authors: Góralski Wojciech 
Published: July 2022

Autor przedstawia i komentuje negatywny wyrok Roty Rzymskiej c. Verginelli z 25 marca 2011 r. w sprawie o nieważność małżeństwa z powodu incapacitas assumendi po stronie mężczyzny (kan. 1095, n. 3 KPK/83), rozpoznawanej w trzeciej instancji (wyrok negatywny w pierwszej, pozytywny w drugiej).
O ile w pierwszej instancji, gdzie instrukcja dowodowa okazała się dość obszerna (ze- znania stron, zeznania siedmiu świadków, opinia biegłego), o tyle w drugiej instancji uzupełniono ją jedynie opinią biegłego sporządzoną na podstawie akt sprawy. Na stopniu rotalnym ograniczało się to do dotychczas zebranego materiału.
Podstawa prawna wyraźnie wskazuje na zgodę małżeńską (actus humanus), a także możliwość jej wyrażenia. Ponens słusznie podkreślił, że mając na uwadze wiele aspek- tów tej zdolności, ważne jest przede wszystkim odniesienie jej do poważnych przyczyn psychologicznych, które uniemożliwiają podmiotowi zawarcie konsensusu małżeńskiego. W uzasadnieniu faktycznym wyroku turnus rotalny ocenił materiał dowodowy zebrany w dwóch pierwszych instancjach. Pewnym mankamentem był tu brak zeznań pozwanego w drugiej instancji oraz niestawiennictwo na badanie biegłego.
Znaczącym było odrzucenie w wyroku rotalnym opinii biegłego (sporządzonej w drugiej instancji) jako niewspółbrzmiącej z innymi dowodami.
CircRNAs: A Novel Strategy in Diagnosis and Treatment of Thyroid
Cancer
Authors: Shafabakhsh Rana , Asemi Zatollah , Mansournia Mohammad Ali , Yousefi Bahman , Hallajzadeh Jamal 
Published: July 2022

Abstract:
Thyroid cancer is one of the most frequent cancers globally, and its incidence
has risen recently. The clinical behavior of thyroid cancer includes a wide range, from
benign to invasive malignant tumors. Thus, precious diagnostic activities before
therapeutic work are required. Circular RNAs (circRNAs) along with microRNAs
(miRNAs) and long non-coding RNAs (lncRNAs) are known as non-coding RNAs
(ncRNAs). Large amounts of investigations have indicated that circRNAs can participate
in multiple cellular processes, especially in tumorigenesis. Furthermore, circRNAs are
stable in blood or plasma, as well as they are specific in different tissues. Therefore,
they could serve as a potential diagnostic biomarker for cancer cells. Limited studies
investigated the role of circRNAs in some processes involved in thyroid cancer. In this
review, we summarized the current evidence on the potential clinical involvement of
circRNAs in thyroid cancer.
Current Overview of Cyclodextrin Inclusion Complexes of Volatile Oils
and their Constituents
Authors: Suvarna Vasanti , Chippa Srilaxmi 
Published: July 2022

Background:
Volatile oils and their constituents have been considered as major bioactive natural compounds due to their wide therapeutic and biological activities in the field of pharmaceuticals in human healthcare. However, due to their poor solubility, their applications are limited. Inclusion complexation of volatile oils and their volatile constituents with cyclodextrins has emerged as a promising approach for the improvement of aqueous solubility, bioavailability, and stability.

Objective:
The present review summarizes various research investigations highlighting the complexation of volatile oils and their constituents with cyclodextrins and their derivatives. Additionally, we present the glimpses of patents published between 1998-2021to highlight the significance of inclusion of volatile oil in cyclodextrins.

Methods:
The selection of articles for the current review was carried out by using keywords ‘Cyclodextrin’, ‘Essential oil’, ‘Inclusion Complex’, ‘Encapsulation’ and ‘Essential oils/ volatile oils constituents’ in certain specific databases such as Elsevier (Science direct), Pubmed Medical subject headings (MeSH) and Medline.

Result:
199 studies published were included in the review. Invitro and invivo studies revealed the efficacy of EOs and their VCs complexed with various types of CD when compared to free forms.

Conclusion:
This review shows the impact of cyclodextrin complexation on the solubility, bioavailability, stability, and biological activities of volatile oils and their constituents.
A Co-Encapsulation of Coenzyme Q10 and Curcumin in Liposomes Coated
with Chitosan (Q10-Cur-Lip-Chi) with Enhanced Solubility and Stability
for Good Release Performance and Antioxidative Activity
Authors: Yu Linjin , Chao Chuyan , Li Qinglan , Ye Songling , Lin Jiasen , Zhong Shuling , Xuan Qiancheng , Xu Kailin , Zhao Suqing 
Published: July 2022

Background:
Coenzyme Q10 (Q10) is a powerful lipophilic antioxidant with poor solubility in aqueous media. Curcumin (Cur) is a natural polyphenolic phytochemical molecule with poor aqueous solubility. Liposome is an improved administration of drugs yet with some drawbacks, such as low bioavailability, poor water solubility. It’s found biocompatible and permeable for nutraceutical delivery. Chitosan, a hydrophilic polymer, is often used as a polymer coating for its good biocompatible and biodegradable properties, and its relatively low toxicity level.

Methods:
Q10 and Cur co-loaded liposomes coated with chitosan (Q10-Cur-Lip-Chi) was constructed. The co-encapsulation of Q10 and Cur in liposomes coated with chitosan was verified by TEM, DLS, DSC, FT-IR, and XRPD. The release profile and antioxidant activity of Q10-Cur-Lip-Chi were accessed.

Results:
The particle size of Q10-Cur-Lip-Chi was about 1440 nm with narrow particle distribution. A
satisfactory encapsulation efficiency (EE) of Q10 was about 98%, and 25% for that of Cur. Q10-Cur-
Lip-Chi showed higher solubility and better pH resistance with 98.5% of Q10 and Cur retention at pH
7.0 - 9.0. Q10-Cur-Lip also showed great salt stability with a vesicle size change of less than 5%. PSof
Q10-Cur-Lip-Chi changed less than 10% at 4°C of storage. Q10-Cur-Lip-Chi also exhibited a good
controlled release profile with its accumulative release of less than 34% for Q10 and 30% for curcumin
after 24 h. The Q10-Cur-Lip-Chi performed a synergistic effect on antioxidant activity reaching
41.86±1.84%, which was 5.9 times higher than that of Q10, 2.5 times higher than that of Cur, and 1.7
times higher than that of the mixture.

Conclusion:
Q10-Cur-Lip-Chi improves the solubility and stability of poorly water-soluble Q10 and Cur for good release performance and antioxidative activity.
An Appraisal on Synthetic and Medicinal Aspects of Fused Pyrimidines as Anti Neoplastic
Agents
Authors: Rani Isha , Kaur Navgeet , Goyal Anju , Sharma Manish 
Published: July 2022

Abstract:
Heterocyclic compounds are recognized to possess a high grade of structural diversity and a broad spectrum
of therapeutic properties. About two-thirds of the New Chemical Entities approved by the FDA against cancer entail
heterocyclic rings and are the foundation stone of medicinal chemistry. Pyrimidine being a major heterocyclic compound
and a crucial base component of the genetic material, has emerged as the key structural component against cancer,
the deadliest disease worldwide. Though many drugs are marketed against cancer, researchers are still investigating
the more promising moieties against various malignancies due to the severity of this disease. In this review, an
attempt has been made to assemble the reported literature of the previous five years on various synthetic procedures
and the anti-cancer potential of various classes of fused pyrimidine analogs, which would help the researchers in designing
new potent derivatives. Besides this, the review intends to focus on the comprehensive discussion on biological
targets, modes of action, and structure-activity relationships of each class of fused pyrimidines as potential anticancer
agents.
Clinical Onset of Action of Incobotulinum Toxin A Preparation
Authors: Marvulli Riccardo , Ranieri Maurizio , Rizzo Laura Belinda , Marra Francesco , Ianieri Giancarlo , Megna Marisa 
Published: July 2022

Background:
Many studies in vitro compared the onset of action, maximum efficacy, and
duration of botulinum toxin type A (BoNT/A) preparations.

Objective:
In this study, we analyzed the onset of action of BoNT/A preparation free of complexing
proteins in patients with upper limb spasticity post stroke up to 30 days after treatment.

Methods:
75 patients affected by Biceps Brachii spasticity were enrolled. Outcome measures were instrumental
muscle tone modification (myometric measurement), improvement of Modified Ashworth
Scale (MAS), improvement of elbow’s passive extension, and improvement of compound muscle action
potential (cMAP) evaluated by electroneurography. We analyzed data at t0 (pre-injection), t1
(1 day after), t2 (7 days after), t3 (14 days after), and t4 (30 days after).

Results:
All measurements decreased at t2, t3, and t4 with initial improvement at t2 and maximum
improvement at t4; no statistical difference at t1 was found.

Conclusion:
This study demonstrated the onset of Incobotulinumtoxin A efficacy started after 7 days;
this rapid action and efficacy of BoNT/A preparation could improve an intensive rehabilitation program
after some days post-injection. Early clinical onset of action could be by the absence of complexing
proteins in the preparation.
The Effects of Nano-curcumin Supplementation on Leptin and Adiponectin
in Migraine Patients: A Double-blind Clinical Trial Study from Gene
Expression to Clinical Symptoms
Authors: Sedighiyan Mohsen , Jafari Elham , Athar Sara Sohrabi , Yekaninejad Mir-Saeed , Alvandi Ehsan , Abdolahi Mina , Djalali Mahmoud 
Published: July 2022

Background:
Migraine is a disabling neurogenic disorder characterized by recurrent
headache attacks. Adipokines act as inflammatory and pain mediators that contribute to migraine
pathogenesis. Leptin and adiponectin levels change in migraine patients and are associated with
headache attacks. Curcumin can exert modulatory and analgesic effects on adipokines through
several mechanisms, from gene expression to suppressing pain. The aim of the present study was
to evaluate the effects of nano-curcumin supplementation on leptin and adiponectin gene expression,
their serum levels and migraine symptoms in patients with migraine.

Methods:
Forty-four episodic migraine patients enrolled in this trial were divided into two groups
as nano-curcumin (80 mg/day) and placebo group, over a two-month period. At the beginning
and the end of the study, the mRNA expression of leptin and adiponectin from isolated PBMCs
and their serum levels were measured using real-time PCR and ELISA method, respectively. The
headache frequencies, severity and duration of pain were also recorded.

Results:
The results of the present research showed that nano-curcumin can up-regulate adiponectin
mRNA and increase its serum level significantly (P < 0.05). In the case of leptin, a reduction
in gene expression and concentration was found in the nano-curcumin group but it was
not statistically significant (P > 0.05). Nano-curcumin also significantly reduced the frequency,
severity and duration of headaches (P < 0.05).

Conclusion:
These findings indicate that nano-curcumin supplement can be considered as a
promising approach to migraine management and clinical symptoms improvement.

Clinical Trial Registration:
IRCT20160626028637N2.
Diagnóstico de la innovación en el sector de producción de alimentos y bebidas de Pasto
Authors: Solarte Solarte Claudia Magali , Rivera Vallejo Gloria Alicia , Bolaños Delgado Sandra Lucía , Benavides Pupiales Luis Eduardo 
Published: July 2022

El estudio pretende fortalecer las capacidades de innovación del sector de producción de alimentos y bebidas del municipio de Pasto para lograr la reactivación económica de la región; de allí la necesidad de realizar una caracterización de la innovación del sector de producción de alimentos y bebidas del municipio de Pasto. La investigación se enmarca en el paradigma positivista, con un enfoque cuantitativo, tipo de investigación descriptivo-analítico; para la obtención de los resultados se empleó el software estadístico SPSS. La población está constituida por 17 empresas del sector de producción de alimentos y bebidas registradas en la Cámara de Comercio de Pasto año 2021, a quienes se les aplicó una encuesta dirigida a los gerentes. Entre los resultados, se encontraron que la mayoría de las empresas presentan la actividad económica 1081 que corresponde a la elaboración de productos de panadería, en su gran mayoría sociedades en comandita por acciones y microempresas no cuentan con un área de innovación. Como conclusiones se obtuvo que las organizaciones no se especializan en procesos de innovación, no existe asignación de recursos, ni personal experto en esta área, por ende, la cultura de innovación es deficiente e incluso consideran que innovar se constituye en un gasto y no una inversión.
Cacos de deus, cacos de casa e cacos de recusa
Authors: Da Silva Diambe 
Published: July 2022

Este relato acadêmico reflete as noções de metabolismo, coreografia e epidemia (seja a de HIV, nos anos 1980, ou de Covid, nos anos 2020) sobre o trabalho videográfico Einstein Remix, de Diambe da Silva, criado a partir do poema homônimo de Ricardo Aleixo, que é sua matéria prima. Desdobramentos sobre o pensamento implicado da filosofia ubuntu e o conceito de coreopolítica de André Lepecki decorrem deste trabalho, que acaba por criar outros poemas pela prática do erro.
Plantações , retomadas e colheitas de sonhos
Authors: Lundu JeisiEkê de 
Published: July 2022

Nessa empreitada escrita performativa faço um caminho de volta para minha criança, retorno a erê guardada em minha caixinha de sonhos para tratar feridas e reencontrar novas encruzilhadas para lidar com o necrocapital urbano. Esse texto nasce da vontade de tramar futuros entendendo que para isso é preciso encontrar na beirada dos barrancos e nos campos, legado de minhas ancestrais as ferramentas necessárias para travar batalhas estelares. o direito ao sonho e ao devaneio, a penumbra, o reencanto, a feitiçaria presente na junção das palavras e no eco dos silêncios.
Situaciones de aprendizaje para la inclusión de la temática ambiental en las clases de química en la secundaria costarricense
Authors: Wendy Villalobos-González  , Kenneth Castillo- Rodríguez  
Published: July 2022

El estudio consistió en la elaboración y evaluación de un Taller de Química Ambiental (TQA) dirigido a estudiantes y profesores de Enseñanza de las Ciencias Naturales de la Universidad Estatal a Distancia de Costa Rica (UNED-CR), con la finalidad de abarcar una serie de situaciones de aprendizaje (SA) para incluir la temática ambiental presente en el Programa de Química de Educación Diversificada del Ministerio de Educación Pública (MEP). El taller se denominó La Química del Ambiente: Una Estrategia para la Inclusión en el Currículo en Secundaria. Las SA incluyeron actividades como: estudios de caso, experimentos caseros, uso de simuladores y proyectos de investigación. El taller se realizó a través de Microsoft Teams® de forma asincrónica, tuvo una duración de dos semanas y contó con una población de 39 participantes. Al finalizar, se aplicó una evaluación mediante un cuestionario tipo encuesta (Forms Office 365®). Se determinó que el taller les facilitó a las personas docentes materiales, herramientas didácticas y situaciones de aprendizaje actualizadas y atractivas para el alumnado con el fin de fomentar habilidades científicas en el aula.
EKSPLORASI KERAGAMAN DAN KAJIAN TAKSONOMI PTERIDOPHYTA SEBAGAI POTENSI EKOWISATA DI KAWASAN PUNCAK DULAMAYO KABUPATEN GORONTALO
Authors: Febriyanti Febriyanti 
Published: July 2022

English translation. This study aims to find out the diversity of pteridophyta species and their taxonomic studies based on morphological character and analysis of Pteridophyta phenetic relationships in the peak area of Dulamayo Gorontalo Regency through exploration and interview methods. Exploration was conducted to obtain species diversity data and taxonomic data of pteridophyta by identifying and recording all morphological characteristics of pteridophyta (Rhizome, Ptiolus and Lamina) found at the research site. Further identification of the micromorphological character of pteridophyta (Scales and Trioma) was carried out at the Laboratory of Botany Of Biology Faculty of MIPA Gorontalo State University. Determination of pteridophyta diversity index using Sahon Wiener formula while phenetic relationship data is analyzed using gower General Similarity Coefficient formula on MVSP softwere. Based on the results of the study obtained 13 species of nail plants that have morphological character variations with a diversity index of H'= 1,087 which fall into the moderate category, namely species Asplenium trichomane, Phymatosorus scolopendria, Christella parasitica and Nephrolepis cordifolia found in kawsan waterfall UPSA, species Sphaerostephanos unitus, Dicksonia circutaria, Balantium antarcticum, Polybotrya alfredii, Pneumatopteris costata, Dryopteris filix-mas, Cyathea arborea, Nephrolepis biserrate and Sellaginella willdenowii are found in the Arboretum. The genetic distance obtained from the analysis of kinship relationships with the phenotic method is at a coefficient of 66% (0.69) which divides into two main clusters based on morphological character similarities.
Development and Assessment of Bioactive Coatings for the Prevention of Recurrent Caries Around Resin Composite Restorations
Authors: Firoozmand LM , Alania Y , Bedran-Russo AK 
Published: July 2022

SUMMARY

Objective
To develop hydrophilic resin-based surface coatings containing bioactive agents (proanthocyanidins from Vitis vinifera and calcium silicate) and assess their protective role at the dentin and enamel margins of cervical restorations against demineralization under simulated conditions of high and low caries activity.

Methods
Suboptimal resin composite restorations were placed on cervical cavity preparations on buccal and lingual surfaces of thirty-two molars after a contamination protocol. Groups were divided according to the resin-based coatings (n=8): resin without bioactive (C), resin containing 2% enriched Vitis Vinifera (VVE), and resin coat containing 10% calcium silicate (CaSi). The control group did not receive a resin (NC). To simulate a hydrolyticenzymatic degradation, specimens were subjected to 2-month storage followed by incubation in esterase at 37°C for 8 days. Afterwards, recurrent caries was induced using a pH-proteolytic model on half of the specimens to simulate high caries activity, and the other half remained in simulated body fluid (SBF). Measurements of cross-section microhardness (KHN) and infiltration with rhodamine-B assessed the micropermeability (MP), the extent of demineralization (ED), and the demineralization area (DA). Data were analyzed using analysis of variance (ANOVA) and post-hoc tests (α=0.05).

Results
VVE and CaSi presented higher cross-sectional KHN values for enamel and dentin (p&lt;0.001). The bioactive coatings resulted in lower MP, ED, and DA compared to NC (p&lt;0.005) in enamel and dentin. CaSi coating preserved the enamel from demineralization (p=0.160).

Conclusion
The application of bioactive coatings represents a potential strategy to protect the enamel-dentin margins of resin restorations.
A “Cátedra por Nariño” na Colômbia
Authors: Girón Daisy Johana Fernández , Felício Helena Maria dos Santos 
Published: July 2022

Neste artigo, analisa-se o desenvolvimento da “Cátedra por Nariño” implementada nos anos de 1980 no Departamento de Nariño, Colômbia, a partir dos participantes da mesma. Utilizaram-se como referenciais teóricos autores como: Shirley Grundy, Paulo Freire, Henry Giroux; dentre outros. Para isto, nesta pesquisa qualitativa interpretativa, foi feito um estudo bibliográfico acerca do objeto de estudo, bem como a realização de entrevistas com alguns professores envolvidos neste processo curricular. Como resultados deste trabalho se construiu como foi o surgimento da “Cátedra por Nariño”, seu desenvolvimento, a conexão da proposta curricular alternativa com a lutas sociais da época, a expansão do projeto dentro de Nariño, e a maneira como finalizou.
E-CITIZENSHIP: THE DIGITAL CITIES PROGRAM, A TOOL FOR A NEW MODEL OF CITIZENSHIP IN BRAZIL
Authors: Barros Manoel Joaquim F. de , Melo Paulo , Lefrançois Denise A 
Published: July 2022

The main objective of this study is to discuss, from a contemporary perspective, how public policies which introduced the concept of digital cities have giving new meanings for the model of citizenship in Brazil and at the same time being an introduction to smart cities projects in near future. What this research is trying to demonstrate is how the digital cities program and its deployments can be a trigger to a new citizenship model in the country. The start point of this study was the concept of citizenship in the context of the dynamics of digital cities. The methodological path followed by the researchers was a qualitative exploratory and bibliographical approach, which begin with the state of art of various aspects of citizenship within the perspective of the public policy that implemented the digital cities program. As a result, it was observed that when there is a massive penetration of digital technologies in the society, in particular in the public sector management, the implementation of citizenship occurs more easily; however, there is still a large portion of the population that remains outside of this process, no longer because of difficulties to have access to internet, which was a limiting factor in the past, but for not understanding the mechanisms of participation and interaction, the new possibilities of internet access nor the importance of using information, what may configure a case of digital illiteracy.
Assessment of Competencies in Technology Operation and Concepts among Teachers in a Philippine State University
Authors: Batan Michael B. , Treceñe Jasten K. D. , Delos Santos Jessie R. N. , Paler Ramelito R. 
Published: July 2022

Being prepared to use technology and knowing how that technology can support student learning have become integral skills in every teacher’s professional repertoire. This study aimed to assess the level of information and communications technology competencies of teachers in higher education, particularly in the technology operations and concepts skills. The study utilized the descriptive design which involved a questionnaire adopted from the National ICT Competency Standard for Teachers. Using the sample size estimation formula for a finite population, 104 teachers in a state university in the Philippines were considered respondents of the study. Responses from the questionnaires were directly encoded and analyzed using the Microsoft Excel application using descriptive statistics such as frequency counts, percentage, and mean. Based on the results, teachers reported a basic competency in understanding and the effective use of the internet and network applications and resources. Also, teachers show a basic competency level in demonstrating knowledge and skills in information and data management. Moreover, teachers reported being proficient in demonstrating knowledge and skills in basic computer operation and other information devices, including basic troubleshooting and maintenance and the use of office and teaching productivity tools. Training can be provided to teachers on technology operations and concepts to further advance their skills and competence which can be applied in their teaching and learning process.