Impact of chronic coronary syndromes on cardiovascular hospitalization and mortality: the ESC-EORP CICD-LT registry
Authors: Kerneis Mathieu , Cosentino Francesco , Ferrari Roberto , Georges Jean-Louis , Kosmachova Elena , Laroche Cécile , Maggioni Aldo P , Rittger Harald , Steg Philippe Gabriel , Maczynska Justyna , Tavazzi Luigi , Valgimigli Marco , Gale Chris P , Komajda Michel ,   CICD investigators group, Tase M , Koci J , Kuka S , Nelaj E , Goda A , Simoni L , Beka V , Dragoti J , Karanxha J , Refatllari I , Goda A , Shehu B , Bileri A , Luzati M , Shuperka E , Gace A , Shirka E , Knuti G , Dado E , Dibra L , Gjana A , Kristo A , Bica L , Kabili S , Pjeci R , Siqeca M , Hazarapetyan L , Drambyan M , Asatrya K , Nersesyan S , Ter-Margaryan A , Zelveian P , Gharibyan H , Hakobyan Z , Sujayeva V , Koshlataya O , Rozumovitch A , Bychkovskaya E , Lavrenova T , Tkacheva L , Dmitrieva I , Serrano C , Cuoco M A , Favarato D , Garzillo C , Goes M , Lima E , Pitta F , Rached F , Segre C , Ayres S , Torres M , Hussein M S , Ragy H , Essam S , Fadala H , Hassan A , Zaghloul S , Zarif B , Elbakery A -E , Nabil M , Mohammed Mounir W , Radwan F , Elmenyawy E , Nafee W , Sabri M , Magdy Moustafa A , Helal A , Mohamed Abdelrahim E , Elseaidy A M A , Yousef A , Albert F , Dasoveanu M , Demicheli T , Dutoiu T , Gorka H , Laure C , Range G , Thuaire C , Lattuca B , Cayla G , Delelo E , Jouve B , Khachab H , Rahal Y , Lacrimini M , Chayeb S , Baron N , Chavelas C , Cherif G , Nay L , Nistor M , Vienet-Legue A , Azowa J -B , Noichri Y , Van Belle E , Cosenza A , Delhaye C , Vincent F , Gaul A , Pin G , Valy Y , Trouillet C , Laurencon V , Couppie P , Daessle J -M , De Poli F , Goioran F , Delarche N , Livarek B , Georges J L , Baron N , Ben Aziza M , Blicq E , Charbonnel C , Convers R , Gibault-Genty G , Azowa J -B , Schiele F , Perruche M L , Cador R , Kerneis M , Lesage J B , Aroulanda M J , Belle L , Madiot H , Chumburidze V , Kikalishvili T , Kharchilava N , Todua T , Melia A , Gogoberidze D , Katsiashvili T , Lominadze Z , Chubinidze T , Brachmann J , Schnupp S , Linss A , Truthan K , Ohlow M -A , Rosenthal A , Ungethüm K , Rieber J , Deichstetter M , Hitzke E , Rump S , Tonch R , Achenbach S , Gerlach A , Schlundt C , Fechner S , Ücker C , Garlichs C D , Petersen I , Thieme M , Greiner R , Kessler A , Rädlein M , Edelmann S , Hofrichter J , Kirchner-Rückert V , Klug A , Papsdorf E , Waibl P , Rittger H , Karg M , Kuhls B , Kuhls S , Eichinger G , Pohle K , Paleczny S , Tsioufis K , Galanakos S , Georgiopoulos G , Panagiotis T , Peskesis G , Pylarinou V , Kanakakis I , Stamatelopoulos K , Tourikis P , Tsoumani Z , Alexopoulos D , Bei I , Davlouros P , Xanthopoulou I , Trikas A , Grigoriou K , Thomopoulos T , Foussas S , Vassaki M , Athanasiou K , Dimopoulos A , Papakonstantinou N , Patsourakos N , Patsilinakos S , Kintis K , Tziakas D , Chalikias G , Kikas P , Lantzouraki A , Karvounis H , Didagelos M , Ziakas A , Sarrafzadegan N , Khosravi A , Kermani-Alghoraishi M , Cinque A , Fedele F , Mancone M , Manzo D , De Luca L , Figliozzi S , Tarantini G , Fraccaro C , Sinagra G , Perkan A , Priolo L , Ramani F , Ferrari R , Campo G , Biscaglia S , Cortesi S , Gallo F , Pecoraro A , Spitaleri G , Tebaldi M , Tumscitz C , Lodolini V , Mosele E , Indolfi C , Ambrosio G , De Rosa S , Canino G , Critelli C , Calzolari D , Zaina C , Grisolia E F , Ammendolea C , Russo P , Gulizia M , Bonmassari R , Battaia E , Moretti M , Bajraktari G , Ibrahimi P , Ibërhysaj F , Tishukaj A , Berisha G , Percuku L , Mirrakhimov E , Kerimkulova A , Bektasheva E , Neronova K , Kaneps P , Libins A , Sorokins N , Stirna V , Rancane G , Putne S , Ivanova L , Mintale I , Roze R , Kalnins A , Strelnieks A , Vasiljevs D , Slapikas R , Babarskiene R , Viezelis M , Brazaitis G , Orda P , Petrauskaite J , Kovaite E , Rimkiene M A , Skiauteryte M , Janion M , Raszka D , Szwed H , Szwed H , Dąbrowski R , Korczyńska A , Mączyńska J , Jaroch J , Ołpińska B , Sołtowska A , Wysokiński A , Kania A , Sałacki A , Zapolski T , Krzesinski P , Skrobowski A , Buczek K , Golebiewska K , Kolaszyńska-Tutka K , Piotrowicz K , Stanczyk A , Sobolewski P , Przybylski A , Harpula P , Kurianowicz R , Wojcik M , Czarnecka D , Jankowski P , Drożdż T , Pęksa J , Mendes M , Brito J , Freitas P , Gama Ribeiro V , Braga P , Ribeiro V G , Melica B , Pires de Morais G , Rodrigues A , Santos L , Almeida C , Pop-Moldovan A L , Darabantiu D , Lala R , Mercea S , Sirbovan I , Pop D , Zdrenghea D , Caloian B , Comșa H , Fringu F , Gurzau D , Iliesiu A , Ciobanu A , Nicolae C , Parvu I , Vinereanu D , Udroiu C A , Cotoban A G , Pop C , Dicu D , Kozma G , Matei C , Mercea D , Tarusi M , Burca M , Bengus C , Ochean V , Petrescu L , Alina-Ramona N , Crisan S , Dan R , Matei O , Lighezan D , Buzas R , Ciobotaru G , Petris A O , Costache I I , Mitu O , Tudorancea I , Parepa I R , Cojocaru L , Ionescu M , Mazilu L , Rusali A , Suceveanu A I , Sinescu C -J , Axente L , Dimitriu I , Samoila N , Mot S , Cocoi M , Iuga H , Dorobantu M , Calmac L , Bataila V , Cosmin M , Dragoescu B , Marinescu M , Tase A , Usurelu C , Dondoi R , Tudorica C C , Vintilă A -M , Ciomag R , Gurghean A , Ianula R , Isacoff D , Savulescu-Fiedler I , Spataru D , Spătaru D V , Horumbă M , Mihalcea R , Balogh C -I , Bakcsi F , Szakacs O -B , Iancu A , Doroltan P , Dregoesc I , Marc M , Niculina S , Chernova A , Kuskaeva A , Novikova D , Kirillova I , Markelova E , Udachkina E , Khaisheva L , Razumovskiy I , Zakovryashina I , Chumakova G , Gritzenko O , Lomteva E , Shtyrova T , Vasileva L , Gosteva E , Malukov D , Pyshnograeva L , Nedbaykin A , Iusova I , Gadgiev R , Grechova L , Kazakovtseva M , Maksimchuk-Kolobova N , Semenova Y , Rusina A , Govorin A , Mukha N , Radaeva E , Vasilenko P , Zhanataeva L , Kosmachova E , Tatarintseva Z , Tripolskaya N , Borovkova N , Tokareva A , Semenova A , Spiropulos N , Ginter Y , Kovalenko F , Brodskaia T , Nevzorova V A , Golovkin N , Golofeevskii S , Shcheglova E , Aleinik O , Glushchenko N , Podbolotova A , Petrova M , Harkov E , Lobanova A , Tsybulskaya N , Iakushin S , Kuzmin D , Pereverzeva K , Shevchenko I , Elistratova O , Fetisova E , Galyavich A , Galeeva Z , Chepisova M , Eseva S , Panov A , Lokhovinina N , Boytsov S , Drapkina O , Shepel R , Vasilyev D , Yavelov I , Kochergina A , Sedykh D , Tavlueva E , Duplyakov D , Antimonova M , Kocharova K , Libis R , Lopina E , Osipova L , Bukatov V , Kletkina A , Plaksin K , Suyazova S , Nedogoda S , Chumachek E , Ledyaeva A , Totushev M , Asadulaeva G , Tarlovskaya E , Kozlova N , Mazalov K V , Valiculova F , Merezhanova A , Efremova E , Menzorov M , Shutov A , Garganeeva A , Aleksandrenko V , Kuzheleva E , Tukish O , Ryabov V , Belokopytova N , Lipnyagova D , Simakin N , Ivanov K , Levashov S , Karaulovskaya N , Stepanovic J , Beleslin B , Djordjevic-Dikic A , Giga V , Boskovic N , Nedeljkovic I , Dzelebdzic S , Arsic S , Jovanovic S , Katic J , Milak J , Pletikosic I , Rastovic M , Vukelic M , Lazar Z , Lukic Petrov J , Stankov S , Djokic D , Kulic N , Stojiljkovic G , Stojkovic G , Stojsic-Milosavljevic A , Ilic A , Ilic M D , Petrovic D , Martínez Cámara A , Rodriguez-Padial L , Sánchez-Aguilera Sánchez-Paulete P , Iniesta Manjavacas A M , Irazusta F J , Merás P , Rial V , Cejudo L , Fernandez Anguita M J , Martinez Mateo V , Gonzalez-Juanatey C , de Dios S , Martí D , Suarez R C , Garcia Fuertes D D , Pavlovic D , Mazuelos F , Suárez de Lezo J , Marin F , Rivera Caravaca J M , Veliz Martínez A , Zhurba S , Mikitchuk V , Sokolov M , Levchuk N , Zhurba S 
Published: April 2022

Abstract

Aims
In Europe, global data on guideline adherence, geographic variations, and determinants of clinical events in patients with chronic coronary syndrome (CCS) remain suboptimal. The European Society of Cardiology (ESC) EURObservational Research Programme (EORP) Chronic Ischemic Cardiovascular Disease Long-Term (CICD-LT) registry is a prospective European registry, and was designed to describe the profile, management, and outcomes of patients with CCS across the ESC countries.

Methods and results
We aimed to investigate clinical events at 1-year follow-up from the ESC EORP CICD-LT registry.
One-year outcomes of 6655 patients from the 9174 recruited in this European registry were analysed. Overall, 168 patients (2.5%) died, mostly from cardiovascular (CV) causes (n = 97, 1.5%). Northern Europe had the lowest CV mortality rate, while southern Europe had the highest (0.5 vs. 2.0%, P = 0.04). Women had a higher rate of CV mortality compared with men (2.0 vs. 1.3%, P = 0.02). During follow-up, 1606 patients (27.1%) were hospitalized at least once, predominantly for CV indications (n = 1220, 20.6%). Among the population with measured low-density lipoprotein-cholesterol level at 1 year, 1434 patients (66.5%) were above the recommended target. Age, history of atrial fibrillation, previous stroke, liver disease, chronic obstructive pulmonary disease or asthma, increased serum creatinine, and impaired left ventricular function were associated with an increased risk of CV death or hospitalization.

Conclusion
In the CICD registry, the majority of patients with CCS have uncontrolled CV-risk factors. The 1-year mortality rate is low, but these patients are frequently hospitalized for CV causes. Early identification of comorbidities may represent an opportunity for enhanced care and better outcomes.