bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ultrasound Assessment of Syndesmotic Injuries in a Pediatric Population
Authors: Heitz Pierre-Henri , Miron Marie-Claude , Beauséjour Marie , DiLiddo Lydia , Hupin Mathilde , Nault Marie-Lyne 
Published: May 2022

Background: Syndesmotic injuries have a higher prevalence in athletes and can present long-term complications particularly in pediatric population. Early diagnosis is necessary and can be done using various modalities, but, they either present poor sensitivity, poor clinical feasibility or are exclusively static. Ultrasound (US) could compensate for those drawbacks. Hypothesis/Purpose: The aim of this study was to determine (1) the benefit of direct visualization of the anterior-inferior tibiofibular ligament (AiTFL) and (2) tibiofibular clear space (TFCS) cut-off points regarding the integrity of the syndesmotic ligaments using US imaging. Methods: A prospective cohort study including all suspected syndesmotic injury in a pediatric population was done. Participants had both ankles assessed with US imaging for description of AiTFL integrity as our static assessment and for TFCS measures as our dynamic evaluation. For dynamic assessment, the distance between the distal tibia and fibula was first measure in neutral position then in external rotation for each ankle. This providing a total of five different TFCS combinations for receiver operating characteristics (ROC) curves analysis. Afterward, the syndesmotic ligament complex and deltoid ligament of the injured ankle were examined using MRI as the gold standard. Results: A total of 26 participants with suspected syndesmotic injuries were included. Mean age was 14.8 years (SD = 1.3 years). Mean time between trauma and US imaging was 56 days (SD = 43.9 days). Sensitivity and specificity of direct visualization of the AiTFL were respectively 0.79 and 1.00 with four false negative tests only found on partial tears. Only two TFCS combinations had an area under the curve (AUC) greater than 0.7 and were then considered for further analysis. The two combinations were the TFCS difference between the injured and uninjured ankle in neutral position (TFCS N I-U) and external rotation (TFCS ER I-U). Cut-off points were ranging from 0.23 mm to 0.37 mm for TFCS N I-U and from 0.11 mm to 0. 30 mm for TFCS ER I-U using ROC curve analysis. Conclusion: US imaging does bring an added value as a screening tool for direct visualization of the AiTFL in pediatric patients by having a good sensitivity, an excellent specificity, a low cost and being easily accessible. The complementary use of dynamic evaluation using TFCS measures could also identify dynamic instability. Cut-off points determined in this study had good sensitivity and specificity but, by being under one millimeter, further studies using dynamic US imaging are needed.
Elevated Anxiety and Depression Symptoms in Injured and Uninjured Adolescents
Authors: Young Julie A. , Allison Ellee , Mohr Drew , Bonny Andrea E. , Valasek Amy E. , Onate James A. 
Published: May 2022

Introduction: Musculoskeletal injuries are common among adolescents with roughly half reporting an injury in the last year. Injury impairs function, but it may impact psychological or behavioral well-being as well. Mental health concerns such as anxiety and depression can negatively affect an adolescent’s quality of life. As mental health disorders are being seen more frequently in the young population it is important to understand their relationship with injury. Athletes who are no longer able to participate in their normal activities due to injury may have elevated symptoms of anxiety and depression from this sudden lifestyle change. The purpose of this study was to determine if a musculoskeletal injury is associated with elevated anxiety and depression in adolescent athletes. Methods: Adolescents between the ages of 12-18 from sports medicine clinics presenting with musculoskeletal injuries were age and sex matched to non-injured adolescents from high school health and weight training classes as well as adolescent medicine clinics. The General Anxiety Disorder-7 and Patient Health Questionnaire-9 were used to assess for anxiety and depression symptoms, respectively. Scores of ≥5 on each questionnaire were considered elevated. Chi-Square analyses analyzed the differences in proportions of elevated anxiety and depression in the injured and uninjured participants. Results: Matched data was available for 108 participants, 54 in each group. Average age was 15.99± 1.58 and 83% were females. Overall, 41% reported elevated anxiety symptoms and 36% reported elevated depressive symptoms. There were no differences in the proportion of injured adolescents that had elevated anxiety or depression compared to uninjured adolescents (p=.386 and p=.071, respectively). Discussion: Elevated anxiety and depressive symptoms are common among injured and non-injured adolescents. High rates in our sample could be impacted by the predominance of female participants, as female are more likely to experience this symptomology than males. It is possible that the severity of the injury may influence anxiety and depression symptoms, which we did not assess. In addition, participants were enrolled during COVID-19, which may have influenced the rates of elevated anxiety and depression symptoms. Elevated anxiety and depressive symptoms are associated with high levels of functional impairment. Therefore, adolescents should be routinely assessed for anxiety and depression, regardless of injured status.
Track and Field Injuries in Children and Adolescents Presenting to us Emergency Departments-An Updated Review of the National Electronic Injury Surveillance System
Authors: Caldwel Kyra , Houlihan Nathan , Whitfield Taraje , Williams Brendan A. 
Published: May 2022

Background: Running is a highly popular activity that fosters healthy lifestyle habits in athletes of all ages. Track and field is a popular competitive youth sport with injuries estimated at 0.84 per 1000 athlete exposures among high school athletes. Injury patterns have been noted to vary by age and differ from those sustained in adult runners. Prior work has examined the epidemiology of youth track and field and running related injuries, but data from the recent decade in the setting of increasing sport specialization and year-round participation is lacking. Purpose: To examine the evolving epidemiology of track and field and running related injuries prompting emergency department presentation. Methods: A retrospective review of data obtained from the National Electronic Injury Surveillance System (NEISS) database was performed identifying children 10-18 with injuries associated with the Track & Field/Running product code (5030) from 2008-2020. National injury estimates were calculated annually and overall. Descriptive statistics were utilized to summarize injury characteristics of the entire cohort. Annual injury estimates were calculated to identify trends over the study period, which included the 2020 season interrupted by the COVID-19 pandemic. Results: We identified 8,399 track and field associated NEISS cases occurring from 2008-2020 representing a national estimate of 271,788 injuries [95% Confidence Interval: 250,288 to 294,24]. The majority (52%) of injuries occurred among patients 15 to 18 years of age. Injuries occurred most frequently in the lower extremity (52%) and most commonly involved the ankle (17%) and knee (15%). Sprain/strains were the most frequent injury type (40%). The majority of patients (97%) did not require hospitalization. Injury estimates of each demographic and injury characteristic with 95% confidence intervals are reported in Table 1. There was a rising annual frequency of track and field injuries seen peaking in 2017 with a notable decline in 2020 during the COVID-19 pandemic. Conclusion: Track and field injuries requiring emergency department presentation appear to be increasing from prior study estimates, but demonstrate similar distribution of injury characteristics. Severe injuries requiring hospitalization remain rare. The majority of injuries involve the knee and ankle and involve older adolescents. This data provides meaningful data for providers caring for and counseling adolescent athletes. [Table: see text]
Sport Specialization and Exposure in a Tertiary Concussion Program
Authors: Storey Eileen P. , Master Stephen R. , Brown Naomi J. , Magrini Danielle M. , Renjilian Chris B. , Turner Christian D. , Vernau Brian T. , Ganley Theodore J. , Arbogast Kristy B. , Grady Matthew F. , Master Christina L. 
Published: May 2022

Background: Sport specialization is an important area of focus within pediatric sports medicine with studies relating specialization to the rising incidence of sport-related injuries. The relationship between sport specialization and concussion remains unexplored. Hypothesis/Purpose: The objective of this study was to assess the prevalence of sport specialization and its relationship to concussion in athletes seen in a tertiary concussion program. Methods: Athletes completed a sport specialization questionnaire as part of a comprehensive intake questionnaire and were classified into low, moderate, or high specialization groups using a previously published 3-point scale. Categories were derived from their responses to 3 binary questions: 1) Have you quit other sports to focus on 1 sport? 2) Do you train >8 months out of the year in 1 sport? 3) Do you consider your primary sport more important than other sports? Results: Of the 1,098 athletes, ages 8-19 years, who completed the questionnaire, 572 (52%) were female, 718 (65.5%) had a sports-related concussion (SRC) and 439 (40%) had a prior history of concussion. The cohort was categorized into low (n=568, 51.7%), moderate (n=339, 30.9%), or high (n=191, 17.4%) sport specialization groups. Athletes reported their primary sport was more important than other sports (702, 64%) and training >8 months out of the year in 1 sport (594, 54%) more commonly than quitting other sports to focus on 1 sport (270, 25%). Sport specialization differed by primary sport (Figure 1), but did not significantly differ when primary sport was grouped by level of contact (p=0.47). Sport specialization did not significantly differ by sex, race, or ethnicity, but significantly differed by insurance (p=0.014) and age (p=0.0001), with greater specialization among those with private insurance and adolescents, respectively. Moderately or highly specialized athletes were significantly more likely than less specialized athletes to present with a SRC compared to a non-SRC (p<0.0001) and to report prior history of concussion (p=0.005). After controlling for demographic and sport participation factors, only endorsement of training more than 8 months out of the year in one sport was significantly associated with SRC (p=0.001) and prior concussion (p=0.007). Conclusion: Sport specialization is prevalent among youth athletes with concussion. Training >8 months out of the year in a single sport is associated with SRC and prior history of concussion. Further research is warranted to evaluate how exposure among specialized athletes relates to concussion.
Connecting Through Conversation: A Novel Video-Feedback Intervention to Enhance Long-Term Care Aides’ Person-Centred Dementia Communication
Authors: O’Rourke Deanne J. , Lobchuk Michelle M. , Thompson Genevieve N. , Lengyel Christina 
Published: May 2022

Objective To pilot test a novel communication intervention incorporating a video-feedback component on the person-centred dementia communication skills of long-term care aides. Methods Effectiveness was assessed using a single group pre-test/post-test design. 11 care aide-resident dyads participated in the study. Objective outcomes included provider statements demonstrating linguistic (i.e., reciprocity, clarity/coherence, and continuity categories) and relational elements of person-centred dementia communication, measured via video-recorded observations of usual care interactions. Subjective outcomes of care aide communication confidence/competence, satisfaction with the resident relationship, relationship closeness, and self-reflection at work were measured using self-report questionnaires. Results In respect to observed person-centred dementia communication skills, there was an increase in the use of linguistic statements in the reciprocity and continuity categories, as well as total linguistic statements overall. Relational statements and overall person-centred dementia communication (i.e., linguistic plus relational strategies) increased. Care aide-reported communication confidence and competence, relationship closeness with the resident, and self-reflection at work also increased after the communication intervention. Discussion The communication intervention showed promise as an effective approach to enhance person-centred dementia communication behaviours in care aides. These results support undertaking a larger trial to examine the intervention’s effectiveness more fulsomely.
Is the Presence of Helicobacter Pylori in the Colonic Mucosa, Provocative of Activity in Ulcerative Colitis?
Authors: Ranjbar Javad , Geramizadeh Bita , Bagheri Lankarani Kamran , Jowkar Zahra , Mirzai Mitra , Moazamian Elham 
Published: May 2022

Background: Epidemiologic studies have shown world-wide increasing incidence of ulcerative colitis (UC) as an autoimmune disease of intestine. In the meantime, gastrointestinal H. Pylori infection is being decreased. Objectives: There are very few studies about comparing the presence of H. Pylori in the colon and the disease activity of UC. There is no study form Iran. In this study, we tried to investigate the presence of H. Pylori in the mucosa of colon by molecular and microbiological as well as pathological methods to find any association between the presence of this organism in the colon and the presence and activity of UC. Patients and Methods: In 100 patients who referred to colonoscopy clinic, colonoscopy was performed. Fifty-seven patients with the new diagnosis of UC were considered as cases and 43 patients with normal screening colonoscopy for polyps were considered as controls. Colon biopsies were evaluated according to histopathology, clinical findings, and laboratory results to confirm the diagnosis and the degree of activity in the cases of UC. Molecular studies were also performed to evaluate the presence of H. Pylori genome in the colon biopsies. A sample of colon was also cultured for H. Pylori. ELISA test was performed in a sample of blood to evaluate the level of IL-10 and IL-17 as regulatory cytokines of inflammation. Results: Cases with the diagnosis of UC showed significantly higher number of positive colonic H. Pylori comparing to normal colonic mucosa. Also, the presence of H. Pylori genome in the colon was associated with higher activity in the cases with UC and higher levels of inflammatory mediators especially IL17 and lower levels of inhibitory mediators such as IL-10. Conclusion: Colonic colonization of H. Pylori was higher in the patients with UC and higher activity of this disease comparing with normal control colonic mucosa.
Subjective Social Status and Mental Health Outcomes: The Role of Mindfulness
Authors: Heitz Hannah K. , Mitchell Amanda M. 
Published: May 2022

Positive personal resources have been shown to buffer the relationship between low subjective social status and poor mental health outcomes. However, limited data exist in relation to the role of mindfulness. The current study investigated how mindfulness moderates the relationship between subjective social status with life satisfaction and subjective well-being. Three hundred and twenty-two adults completed measures assessing subjective social status, as measured by the society and community ladders, mindfulness, life satisfaction, and well-being. Using PROCESS, a macro for SPSS and SAS, mindfulness was found to significantly moderate the relationship between society ladder and life satisfaction (△ R2 = .02, 95% confidence interval (CI) [−0.93, −0.15], p = .007) as well as the community ladder and life satisfaction (△ R2 = .01, 95% CI [−.92, −0.11], p = .013). No significant moderating effect was found between the society ladder and subjective well-being (95% CI [−0.59, 1.73], p = .335) or the community ladder and subjective well-being (95% CI [−0.82, 1.54], p = .551). These findings underscore the value of investigating how positive personal resources, such as mindfulness, impact the subjective social status-well-being relationship. Additional research examining the subjective social status–health relationship through a strengths-based lens will be fruitful in identifying resources that promote positive outcomes in the face of economic marginalization.
Maternal serum CFHR4 protein as a potential non-invasive marker of ventricular septal defects in offspring: evidence from a comparative proteomics study
Authors: He Jing , Xie Liang , Yu Li , Liu Lijun , Xu Hong , Wang Tao , Gao Yuyang , Wang Xuedong , Duan You , Liu Hanmin , Dai Li 
Published: May 2022

Abstract
Background
Despite advances in diagnosis of congenital heart defects, there is no non-invasive biomarker clinically available for the early detection of fetal ventricular septal defects (VSD).

Methods
This study was to profile differentially expressed proteins (DEP) in the first trimester maternal plasma samples that were collected in the 12th–14th week of gestation and identify potential biomarkers for VSD. Maternal plasma samples of ten case–control pairs of women (who had given birth to an isolated VSD infant or not) were selected from a birth cohort biospecimen bank for identifying DEPs by using high-performance liquid chromatography-tandem mass spectrometry-based comparative proteomics.

Results
There were 35 proteins with significantly different levels between cases and controls, including 9 upregulated and 26 downregulated proteins. With Gene Ontology, Kyoto Encyclopedia of Genes and Genomes pathway enrichment, and protein–protein interaction analyses, most of the DEPs were clustered in pathways related to B cell-mediated immune responses, complement activation, and phagocytosis. Three DEPs were validated using enzyme-linked immunosorbent assay in another set of samples consisting of 31 cases and 33 controls. And CFHR4, a key regulator in complement cascades, was found to be significantly upregulated in cases as compared to controls.

Conclusions
Subsequent logistic regression and receiver operating characteristic analysis suggested maternal serum CFHR4 as a promising biomarker of fetal VSD. Further studies are warranted to verify the findings.
Diverging trends of plasticizers (phthalates and non-phthalates) in indoor and freshwater environments—why?
Authors: Nagorka Regine , Birmili Wolfram , Schulze Jona , Koschorreck Jan 
Published: May 2022

AbstractBackgroundEuropean chemicals management aims to protect human health and the environment from legacy and emerging contaminants. The plasticizer market changed in response to the restriction of low molecular weight (LMW) phthalate plasticizers such as Di (2-ethylhexyl) phthalate (DEHP) due to their hazardous properties. We investigated patterns and trends of 19 regulated and emerging plasticizers in house dust from German homes and in suspended particulate matter (SPM) from major German rivers. The samples were used from the mid-2000s and late 2010s from two governmental long-term monitoring programs in Germany.ResultsWhile the sum of the respective plasticizer levels hardly changed over the study period, we observed a significant decrease of LMW phthalates in both house dust (2003/06, 80% of the ∑plasticizer concentration; 2014/17, 31%) and SPM (2005, 48%; 2017, 28%). This was accompanied by their substitution with high molecular weight (HMW) phthalates and non-phthalates. HMW phthalates increased from 19% of the ∑plasticizer concentration to 46% between the mid-2000s and the late 2010s in house dust, and from 50% to 63% in SPM samples. Diisononyl phthalate (DINP) replaced DEHP as the dominant plasticizer in both compartments. A significant tenfold increase (p < 0.05) was observed in SPM samples for Di (2-propylheptyl) phthalate (DPHP) (1–13%), compared to low levels in house dust (2014/17, 1%). Non-phthalates increased to 23% of the ∑plasticizer concentration in house dust but only to 9% in SPM (mid-2000s: house dust, < 1%; SPM, 1.5%). In recent house dust samples, Di (2-ethylhexyl) terephthalate (DEHT) had the third highest concentration of all plasticizers and contributed 18% to the total load, whereas Tris (2-ethylhexyl) trimellitate (TOTM) was one of the major non-phthalates in SPM samples.ConclusionsUnlike in the indoor environment, the substitution of LMW phthalates in the aquatic environment was characterized by a significant shift towards plasticizers with potentially hazardous properties. DPHP and TOTM were identified by European chemical regulation as potentially endocrine disrupting compounds and persistent, bioaccumulative and toxic compounds. Our data document the need for integrated chemicals management to safeguard the transition to a non-toxic environment.
Model verification tools: a computational framework for verification assessment of mechanistic agent-based models
Authors: Russo Giulia , Parasiliti Palumbo Giuseppe Alessandro , Pennisi Marzio , Pappalardo Francesco 
Published: May 2022

AbstractBackgroundNowadays, the inception of computer modeling and simulation in life science is a matter of fact. This is one of the reasons why regulatory authorities are open in considering in silico trials evidence for the assessment of safeness and efficacy of medicinal products. In this context, mechanistic Agent-Based Models are increasingly used. Unfortunately, there is still a lack of consensus in the verification assessment of Agent-Based Models for regulatory approval needs. VV&UQ is an ASME standard specifically suited for the verification, validation, and uncertainty quantification of medical devices. However, it can also be adapted for the verification assessment of in silico trials for medicinal products.ResultsHere, we propose a set of automatic tools for the mechanistic Agent-Based Model verification assessment. As a working example, we applied the verification framework to an Agent-Based Model in silico trial used in the COVID-19 context.ConclusionsUsing the described verification computational workflow allows researchers and practitioners to easily perform verification steps to prove Agent-Based Models robustness and correctness that provide strong evidence for further regulatory requirements.