bluuebunny/crossref_metadata_2025_split huggingface dataset:
Risk factors of pregnancy outcome in patients with pulmonary hypertension
Authors: Zhao Kaixun , Yang Ziyang , Zhou Yin , Xie Nanshan , Lai Disheng , Zhang Caojin 
Published: July 2022

Abstract
OBJECTIVE: The purpose of this study is to explore the factors affecting the pregnancy outcome of patients with pulmonary hypertension, and to design a digital model predicting the pregnancy outcome of patients and judge whether patients have the conditions to continue pregnancy. METHODS: The clinical data of patients with pregnancy complicated with pulmonary hypertension hospitalized in Guangdong Provincial People's Hospital from January 1, 2014 to December 31, 2020 were retrospectively analyzed. The severity of pulmonary hypertension, the structural and functional indexes measured by echocardiography were compared, and the effects on maternal and neonatal outcomes were analyzed. RESULTS: A total of 158 patients met the inclusion and exclusion criteria. The results showed that tricuspid regurgitation velocity (P<0.001), right ventricular diameter (P<0.05), right atrial diameter (P<0.05), pulmonary artery diameter (P<0.001) and cardiac function classification (P<0.001) were risk factors for maternal outcomes; Tricuspid regurgitation velocity (P<0.001) and structural changes of right heart were risk factors for neonatal outcomes. By multivariate logistic regression analysis, tricuspid regurgitation velocity (P<0.001), cardiac function (P<0.05) and superior inferior diameter of right atrium (P<0.05) were significant risk factors for maternal outcomes, while tricuspid regurgitation velocity (P<0.001) and superior inferior diameter of right atrium (P<0.05) were significant risk factors for neonatal outcomes. Using significant risk factors, a risk score system was established to predict the pregnancy outcome. CONCLUSION: in this study, we analyzed the clinical data of patients with pregnancy complicated with pulmonary hypertension in our hospital in recent years, and found that the changes of right heart structure (the acceleration of tricuspid regurgitation velocity, and the increase of right atrium, right ventricular diameter, right ventricular outflow tract anteroposterior diameter and main pulmonary artery diameter), are influencing factors of pregnancy outcomes in patients with pulmonary hypertension. In addition, we preliminarily designed a risk score through multi factor analysis, which is helpful to predict the possible outcome of puerperium and neonatal outcomes of patients, and to provide some reference for clinicians and patients to make decisions on whether to continue pregnancy in clinical practice.
Known risk factors of the developmental dysplasia of the hip predicting more severe clinical presentation and failure of Pavlik harness treatment
Authors: Lankinen Vilma , Bakti Karim , Helminen Mika , Väli-Pakka Jarmo , Laivuori Hannele , Hyvärinen Anna 
Published: July 2022

Abstract
Purpose. Developmental dysplasia of the hip (DDH) varies from mild instability of the hip to subluxation or total dislocation of the joint. Well-known risk factors of DDH include pre-natal breech position, female sex, positive family history, hip side, primiparity and the mode of delivery. Aim of the present study was to further evaluate known risk-factors of DDH, find associations with more severe dysplasia (characterized with Ortolani positivity) and find risk factors of failure of the Pavlik harness treatment. Material and methods. All children with the diagnosis of DDH treated in Tampere University hospital in the years 1998-2018 were retrospectively identified for the study and the data was collected from the medical records. Total of 948 patients were included.Results. Breech presentation was strongly associated with Ortolani positivity (p<0.001). Among breech born infants C-section was strongly associated with Ortolani positivity (p<0.001) (OR 1.833, CI95% 1.332-2.524), whereas vaginal delivery was not (p=0.420). Breech presentation was not associated with ending up for spica casting and/or operative treatment (p=0.849) despite the association with Ortolani positivity.Ortolani positivity (p=0.002), positive family history (p=0.013) and primiparity (p=0.048) were associated with ending up for spica casting and/or operative treatment. Conclusion. Breech presentation seems to increase the risk of Ortolani positive DDH. However, these infants are likely to recover with initially started Pavlik harness treatment, as it was not associated with elevated risk for undergoing more robust treatments. Positive family history is associated with the most severe cases of developmental dysplasia of the hip, and it may predispose to the failure of the Pavlik harness treatment.
Evaluation of landslide susceptibility based on VW-AHP-IV model: a case of Pengyang County, Ningxia, China
Authors: Li Minghong , Ma Chuanming , Qiu Yang , Xiong Hanxiang , Zhang Zechen 
Published: July 2022

Abstract
Landslide is one of the most common and severe geological disasters, which significantly endangers people's lives and properties. Therefore, the evaluation of landslide susceptibility in a specific area is important for disaster control and mitigation. This paper selected Pengyang County as the study area. It divided the indicator state levels, and further assigned a score for each indicator according to the related information values (IV) based on the analysis of graded area ratio and landslide occurrence frequency distribution. Because the solo analytical hierarchy process (AHP) method always causes large errors during the weight determination, a variable-weight based weighted information value (VW-AHP-IV) model was applied in this paper for landslide susceptibility evaluation. The study area was classified into four grades by the natural breakpoint method: high susceptibility area (11.80%), medium susceptibility area (29.23%), low susceptibility area (42.45%) and very low susceptibility area (16.52%). In addition, this paper also discussed the influences of precipitation and human activities. According to the evaluation results and discussion, the study area was classified into three prevention and control areas: focus prevention and control area, sub-focus prevention and control area, and general prevention and control area. For each area, the corresponding prevention and control suggestions were proposed in order to reduce the occurrence of landslide disasters.
Design and Analysis of Novel High-Performance III-Nitride MQW-based Nanowire White-LED using HfO2/SiO2 Encapsulation
Authors: Das Samadrita , Lenka Trupti Ranjan , Talukdar Fazal A , Velpula Ravi Teja , Nguyen Hieu Pham Trung 
Published: July 2022

Abstract
A novel, white light-emitting diode structure with improved thermal characteristics is designed for providing efficient light which may be used especially in the underground mining environment. It describes a new nano-hafnium oxide-silica based LED encapsulation material that promises enhanced package LED efficiency by 29.05% and indicates a reduction in the efficiency droop (0.491%). The enhanced power and efficiency of the LED with HfO2/SiO2-doped bi-layer are attributed to the significant minimization of overflow of electrons which is fundamentally responsible for efficiency degradation through p-GaN region. In this article encapsulant material based on nano- HfO2/SiO2 not only enhances light extraction but opens a broad new range of encapsulant engineering capabilities composites. Our designed LED is generated from a monolithic composition of blue and yellow spectrum which eventually creates the white light. This minimizes the problems related to multiple numbers of LEDs, green gap and phosphor color rendering.
Moderating effects of uric acid and gender on non-motor symptoms in asymmetric Parkinson's disease
Authors: Peron Julie , Constantin Ioana , Voruz Philippe 
Published: July 2022

Abstract
The interplay between uric acid, gender, and motor symptom asymmetry in the manifestation of non-motor symptomatology (NMS) remains to be better understood in early-stage Parkinson’s disease (PD). A total of 413 patients taking part in the Parkinson’s Progression Marker Initiative were divided into six groups based on their motor symptom asymmetry and gender. Clinical data was extracted over a 5-year follow-up period. Three-way interaction modeling was used to examine the moderating effects of gender and UA in the relationship between motor symptom asymmetry and NMS. The results highlighted significant moderating effects of uric acid on NMS in female PD patients, but not in male PD patients. Furthermore, female patients with right-sided motor symptom onset demonstrated the most preserved NMS functioning in the presence of lower serum uric acid levels, while their male counterparts showed the most impairment. This holds important clinical implications for symptom management in early-stage PD patients.
Removal of Cesium and Strontium for radioactive wastewater by Prussian blue nanorods
Authors: Yao Chuqing , Dai Yaodong , Chang Shuquan , Zhang Haiqian 
Published: July 2022

Abstract
In this work, novel Prussian blue tetragonal nanorods were prepared by template-free solvothermal methods for removal of radionuclide Cs and Sr. It was worth that Prussian blue nanorods exhibited the better adsorption performance than co-precipitation PB or Prussian blue analogue composites. Thermodynamic analysis implied that adsorption process was spontaneous and endothermic which was described well with Langmuir isotherm and pseudo-second-order equation, the maximum adsorption capacity of PB nanorod was estimated to be 194.26 mg g− 1 and 256.62 mg g− 1 for Cs+ and Sr2+. The adsorption mechanism of Cs+ and Sr2+ was studied by X-ray photoelectron spectroscopy, X-ray diffraction and 57Fe Mössbaure spectroscopy, the results revealed that Cs+ entered in PB crystal to generate a new phase, the most of Sr2+ was trapped in internal crystal and the other exchanged Fe2+. Furthermore, the effect of co-existing ions and pH for PB adsorption process were also investigated. The results suggest that PB nanorods were outstanding candidate for removal of Cs+ and Sr2+ from radioactive wastewater.
Selection of outsourcing logistics providers in the context of low-carbon strategies: A grey-VIKOR method and its application
Authors: Cheng Cheng , Wang Xiaomin , Ren Xiaohang 
Published: July 2022

Abstract
As more attention is given to climate change and sustainable development, enterprises start to care about carbon emissions related to their supply chains. One important issue faced by an enterprise is to select a logistics provider who can provide a high-quality service with low carbon levels. To solve this issue, this paper firstly proposes selection criteria from the perspective of low carbon levels. The selection criteria are based on comprehensive strength, financial status, market competitiveness, development potential and low carbon level. Next, this paper applies an information entropy VIKOR model to evaluate the proposed selection criteria. Subsequently, in order to check the applicability of our proposed selection model and to illustrate how to use the selection model, this paper took S company and its four logistics providers as a case study. Related suggestions are also proposed based on the evaluation results. One finding of this paper is to establish a decision-making framework to evaluate logistics suppliers in an environment using low-carbon level criteria.
Pharmacological evaluation of Embelin in Benzo[α]pyrene induced experimental model of cognitive and memory impairment in mice
Authors: Goal Akansh , Singh Shamsher , Raj Khadga , Arora Ripmi 
Published: July 2022

Abstract
Alzheimer's disease (AD) is a neurodegenerative disease that affects the neurons in the hippocampus, resulting in cognitive and memory impairment. The production of amyloid-beta (Aβ) plaques, neurofibrillary tangles, and neuroinflammation in neurons are the most prominent clinical characteristics of AD. It has been proven that Embelin (Emb) possess antioxidant, anti-inflammatory, and neuroprotective properties. Therefore, we assessed the therapeutic potential of Emb in Benzo(α)pyrene (BaP)-induced cognitive impairment in experimental mice. BaP (5 mg/kg, i.p) was given to mice daily for 28 days, and Emb (2.5, 5, and 10 mg/kg, i.p) was given for 14 days after the BaP treatment. Locomotor activity was evaluated using open-field and spatial working, and non-spatial memory was evaluated using novel object recognition tasks (NORT), Morris water maze (MWM), and Y- maze. At the end of the study, the animal tissue homogenate was used to check biochemicals, neuroinflammation, and neurotransmitter changes. BaP treated mice showed a significant declined in locomotor activity, learning and memory deficits and augmented oxidative stress (lipid peroxidation, nitrite and GSH). Further, BaP promoted the release of inflammatory tissue markers, decreased acetylcholine, dopamine, GABA, serotonin and norepinephrine and increased glutamate concentration. However, treatment with embelin at dose-dependently prevented biochemical changes, improved antioxidant levels, reduced neuroinflammation, restored neurotransmitter concentration and inhibited the NF-κB pathway. The current study's finding suggested that Emb improved cognitive functions through antioxidant, anti-inflammatory, neuroprotective mechanisms and inhibition of acetylcholinesterase (AChE) enzyme activities and Aβ-42 accumulation.
Does invasion science encompass the invaded range? A comparison of the geographies of invasion science versus management in the U.S.
Authors: Munro Lara , Griffin Bridget , Laginhas Brittany , Bradley Bethany A. 
Published: July 2022

Abstract
Biases in invasion science have led to a taxonomic focus on plants, particularly a subset of well-studied plants, and a geographic focus on invasions in Europe and North America. Geographic biases could also cause invasion science to focus on a subset of the invaded range, potentially leading to an incomplete understanding of the ecology and management of plant invasions. While broader, country-level geographic biases are well known, it is unclear whether these biases extend to a finer scale and thus affect insights within the invaded range. This study assessed whether research sites for ten well-studied invasive plants in the U.S. are geographically biased relative to each species’ known invaded range. We compared the distribution, climate, and land uses of research sites for 735 scientific articles to manager records from EDDMapS and iMap Invasives representing the invaded range. We attributed each study to one of five types: impact, invasive trait, mapping, management, and recipient community traits. While the number of research sites was much smaller than the number of manager records, they generally encompassed similar geographies. However, research sites tended to skew towards species’ warm range margins. For all but one species, at least one study type encompassed a significantly different climate space from manager records, suggesting that some level of climatic bias is common. Impact and management studies occurred within the same climate space for all species, suggesting that these studies focus on similar areas – likely those with the greatest impacts and management needs. Manager records were more likely to be found near roads, which are both habitats and vectors for invasive plants, and on public land. Research sites were more likely to be found near a college or university. Overall, we did not find evidence for substantial geographic biases in research studies of these well-studied species, suggesting that researchers are generally doing a good job of exploring the impacts, traits, and management implications of invasions across the extents of the invaded range. However, the consistent climatic biases and spatial clustering of specific study types suggests that researchers and managers should use caution when developing inference for understudied geographic areas.
Sex differences in inflammation in the hippocampus and amygdala across the lifespan associations with cognitive bias
Authors: Hodges Travis E. , Lieblich Stephanie E. , Rechlin Rebecca K. , Galea Liisa A.M. 
Published: July 2022

Abstract
Background: Cognitive symptoms of major depressive disorder, such as negative cognitive bias, are more prevalent in women than in men. Cognitive bias involves pattern separation which requires hippocampal neurogenesis and is modulated by inflammation in the brain. Previously, we found sex differences in the activation of the amygdala and the hippocampus in response to negative cognitive bias that varied with age. Given the association of cognitive bias to neurogenesis and inflammation, we examined associations between cognitive bias, neurogenesis in the hippocampus, and cytokine and chemokine levels in the ventral hippocampus (HPC) and basolateral amygdala (BLA) of males and females across the lifespan. Results: After cognitive bias testing, males had more IFN-γ, IL-1β, IL-4, IL-5, and IL-10 in the ventral HPC than females in adolescence. In young adulthood, females had more IFN-γ, IL-1β, IL-6, and IL-10 in the BLA than males. Middle-aged rats had more IL-13, TNF-α, and CXCL1 in both regions than younger groups. Neurogenesis in the dorsal hippocampus was negatively associated with negative cognitive bias in young adult males. Conclusions: Overall, the association between negative cognitive bias, hippocampal neurogenesis, and inflammation in the brain differs by age and sex. Hippocampal neurogenesis and inflammation may play greater role in the cognitive bias of young males compared to a greater role of BLA inflammation in adult females. These findings lay the groundwork for the discovery of sex-specific novel therapeutics that target region-specific inflammation in the brain and hippocampal neurogenesis.
Shared and distinct neural correlates of first and second language morphological processing in bilingual brain
Authors: Yuan Zhen , Gao Fei , Hua Lin , Paulo Armada-da-Silva , Zhang Juan , Li Defeng , Chen Zhiyi , Du Meng 
Published: July 2022

Abstract
While morphology constitutes a crucial component for linguistic and psycholinguistic theories as well as the human language faculty, the neural bases of morphological processing in the human brain remains to be elucidated. This current study aims at exploring the extent to which the second language (L2) morphological processing would resemble or differ from that of their first language (L1) in adult Chinese-English bilinguals. Bilingual participants were asked to complete a morphological priming lexical decision task drawing on derivational morphology, which is present for both Chinese and English, when their electrophysiological and optical responses were recorded concurrently. Functional near-infrared spectroscopy (fNIRS) revealed a neural dissociation between morphological and semantic priming effects in the left fronto-temporal network, while L1 Chinese engaged enhanced activation in the left prefrontal cortex for morphological parsing relative to L2 English. In the early stage of lexical processing, cross-language morphological processing manifested a difference in degree, not in kind, as revealed by the early left anterior negativity (ELAN) effect. In addition, L1 and L2 shared both early and late structural parsing processes (P250 and 300 ~ 500 ms negativity, respectively). Therefore, the current results support a unified competition model for bilingual development, where bilinguals would primarily employ L1 neural resources for L2 morphological representation and processing.
Telemedicine in the treatment of gestational diabetes: pregnancy outcomes and maternal satisfaction.
Authors: Montori Sara , Lugli Francesca , Monesi Marcello , Scutiero Gennaro , Greco Pantaleo , Verteramo Rosita 
Published: July 2022

Abstract
PURPOSE The treatment of gestational diabetes requires several outpatient visits, from diagnosis until delivery, to prevent maternal and fetal complications associated to hyperglycemia. In literature there is poor evidence about the telemedicine systems superiority in improving pregnancy outcomes, in women with gestational diabetes.The aim of the study is to evaluate the maternal and fetal outcomes and the degree of satisfaction in gestational diabetes treatment, through exclusive telemedicine versus outpatient follow-up.METHODS 62 consecutive women with gestational diabetes were recruited by the Diabetology Unit of Ferrara: 29 randomized to a weekly remote control (telemedicine group); 33 checked in presence every two or three weeks (conventional group). To assess satisfaction with diabetes care, 58 women replied postpartum to the modified Oxford Maternity Diabetes Treatment Satisfaction Questionnaire.RESULTS No statistically significant differences were found in most of the obstetric and neonatal clinical parameters evaluated in both groups. The analysis of the questionnaire answers showed favorable scores in all areas explored. Telemedicine follow-up makes women feel more controlled (P= 0.007) and fits better to their lifestyle (P = 0.001). It also emerged that almost all women treated with telemedicine would recommend this method to a relative or a friend.CONCLUSION Telemedicine follow-up proved to be safe both on metabolic control and pregnancy outcomes; furthermore, it significantly decreases outpatient visits and increases women satisfaction. Studying the impact of telemedicine is also necessary, considering the difficulties associated with the Sars-COV-2 pandemic. In the future, it is desirable to expand the cohort of patients.
Corticostriatal projections relying on GABA levels encode exercise-induced functional recovery in cerebral ischemic mice
Authors: Xing Ying , Zhang Anjing , Li Congqin , Han Jing , Wang Jun , Luo Lu , Chang Xuechun , Tian Zhanzhuang , Bai Yulong 
Published: July 2022

Abstract
Stroke is a neurological disorder characterized by high disability and death worldwide. The occlusion of the middle cerebral artery (MCAO) supplying the motor cortical regions and its projection pathways regions can either kill the cortical neurons or block their projections to the spinal cord and subcortical structure. The cerebral cortex is the main striatal afferent, and the medium spiny neurons of the striatum have been identified as the major output neurons projecting to substantia nigra and pallidum. Thus, disconnection of the corticostriatal circuit often occurs in the model of MCAO. In this study, we hypothesize that striatal network dysfunction in cerebral ischemic mice ultimately modulates the activity of striatal projections from cortical neurons to improve dysfunction during exercise training. In this study, we observed that corticostriatal circuit originating from glutamatergic neurons can partially medicate improvement of motor and anxiety-like behavior in mice with exercise. Furthermore, exercise or activation of a single optogenetic corticostriatal circuit can increase the striatal gamma-aminobutyric acid (GABA) level. Using the GABA-A receptor antagonist, bicuculline, we further identified that the glutamatergic projection of the cortex in the striatum relies on activity of GABAergic synapse to modulate exercise-induced functional recovery. Overall, those results reveal that the dorsal striatum-projecting subpopulation of cortical glutamatergic neurons can influence GABA levels in the striatum, playing a critical role in modulating exercise-induced improvement of motor and anxiety-like behavior.