bluuebunny/crossref_metadata_2025_split huggingface dataset:
Generic instruments in a synchrotron radiation facility
Authors: Söderström Kristofer Rolf , Åström Fredrik , Hallonsten Olof 
Published: May 2022

Abstract
This paper explores the concept and the levels of genericity of different instruments, or beamlines, at a synchrotron radiation facility. We use conceptual tools from the sociology of science, bibliometrics and data from the European Synchrotron Radiation Facility (ESRF) publication database, enriched by data from Web of Science. The sample size is of 11,218 observations for the period 1996 to 2018. The combined data set includes the beamline name, available from the ESRF library database, which makes the instrument-level analysis possible. We operationalize instrument genericity as the disciplinary diversity in the corpus related to each instrument with a Herfindahl-based index theoretically supported by the concept of generic instruments. As a result, we gain a quantitative insight into the generic character of the instruments, as well as the way in which different scientific fields and the experimental use of instruments group and align.
The effect of academic mobility on research performance: The case of Italy
Authors: Abramo Giovanni , D’Angelo Ciriaco Andrea , Di Costa Flavia 
Published: May 2022

Abstract
This work investigates the effects of researchers’ mobility on their research performance. The reference context is that of national intrasector mobility, in a country, Italy, characterized by a research system lacking the typical elements of an academic labor market. In particular, the analysis was conducted on 568 academics working at national universities and affected by mobility in the period 2009–2014. The effect of mobility on the variation of performance at the turn of the transfer was analyzed considering the interplay of demographic/sociological characteristics of the researchers, as well as contextual factors related to both the organization of origin and destination. Results show that it is the less productive academics who represent the larger share of those who move, and more than half of the mobile academics worsen their performance after the transfer.
Diurnal Cycle and Dipolar Pattern of Precipitation over Borneo during an MJO Event: Lee Convergence and Offshore Propagation
Authors: Zhou Yihao , Wang Shuguang , Fang Juan 
Published: May 2022

Abstract
Surface precipitation anomalies over Maritime Continent islands typically lead oceanic precipitation by a week in the form of dipolar pattern before the arrival of Madden–Julian oscillation (MJO) convective phase. The authors study this dipolar pattern over Borneo during the boreal winter MJO event in January–February 2017 using cloud-permitting modeling, observation, and reanalysis datasets. The diurnal cycles of precipitation are analyzed during the local growing and decaying stages of this MJO event. Both the observation and simulation show positive precipitation anomaly over southwestern Borneo and negative anomaly over northeastern Borneo associated with the MJO easterly in the growing stage, whereas the pattern reverses in the decaying stage. Due to relatively high terrain, the low-level flows over Borneo split near the topography on the diurnal time scale. During the late afternoon and night (1700–2000 local solar time), the splitting-flow-induced wake vortices and thermally driven sea breezes tend to converge at the leeside, both contributing to leeward convergence and precipitation, which peaks at midnight. Subsequent offshore propagation during midnight and early morning develops from the leeward inland convection, and propagates northwestwards in the growing stage over west Borneo, and eastward in the decaying stage over east Borneo. Offshore propagation lasts until the next noon when sea breezes and island convection initiate. The timing and location of the offshore propagation suggest that it is not an independent convective mode. Instead, it is tied to the dipolar distribution of island precipitation modulated by the MJO.
ACCESS-C: Australian Convective-Scale NWP with Hourly 4D-Var Data Assimilation
Authors: Rennie Susan , Cooper Shaun , Steinle Peter , Dietachmayer Gary , Krysta Monika , Franklin Charmaine , Bridge Chris , Marshall Matthew , Xiao Yi , Sgarbossa Dean 
Published: May 2022

Abstract
The Australian Bureau of Meteorology recently upgraded its convection-allowing numerical weather prediction system, known as the Australian Community Climate and Earth System Simulator (ACCESS-C). ACCESS-C includes seven domains covering major population centers, nested inside the Bureau’s global NWP system. The upgrade included the introduction of data assimilation, with hourly cycling 4D-Var. With a much newer version of the Unified Model to provide the forecast, a range of storm attribute diagnostics to improve forecasting of severe weather events could be introduced. This paper details the configuration of the new version of ACCESS-C. Some verification compared with its predecessor (a downscaling system of comparable resolution) is presented. Of greater note is an exploration of the differences in the model characteristics between the new and old systems, which will affect how users interpret the outputs.
An overview of current drugs and prophylactic vaccines for coronavirus disease 2019 (COVID-19)
Authors: Alagheband Bahrami Armina , Azargoonjahromi Ali , Sadraei Samin , Aarabi Aryan , Payandeh Zahra , Rajabibazl Masoumeh 
Published: May 2022

AbstractDesigning and producing an effective vaccine is the best possible way to reduce the burden and spread of a disease. During the coronavirus disease 2019 (COVID-19) pandemic, many large pharmaceutical and biotechnology companies invested a great deal of time and money in trying to control and combat the disease. In this regard, due to the urgent need, many vaccines are now available earlier than scheduled. Based on their manufacturing technology, the vaccines available for COVID-19 (severe acute respiratory syndrome coronavirus 2 (SAR-CoV2)) infection can be classified into four platforms: RNA vaccines, adenovirus vector vaccines, subunit (protein-based) vaccines, and inactivated virus vaccines. Moreover, various drugs have been deemed to negatively affect the progression of the infection via various actions. However, adaptive variants of the SARS-CoV-2 genome can alter the pathogenic potential of the virus and increase the difficulty of both drug and vaccine development. In this review, along with drugs used in COVID-19 treatment, currently authorized COVID-19 vaccines as well as variants of the virus are described and evaluated, considering all platforms.Graphical abstract
Genomic analysis of two Chinese isolates of hyphantria cunea nucleopolyhedrovirus reveals a novel species of alphabaculovirus that infects hyphantria cunea drury (lepidoptera: arctiidae)
Authors: Peng Xiaowei , Zhang Wenying , Lei Chengfeng , Min Shuifa , Hu Jia , Wang Qinghua , Sun Xiulian 
Published: May 2022

Abstract
Background
Baculoviruses act as effective biological control agents against the invasive pest Hyphantria cunea Drury. In this study, two Chinese Hyphantria cunea nucleopolyhedrovirus (HycuNPV) isolates, HycuNPV-BJ and HycuNPV-HB, were deep sequenced and compared with the Japanese isolate, HycuNPV-N9, to determine whole-genome level diversity and evolutionary history.

Results
The divergence of the phylogenetic tree and the K2P distances based on 38 core-gene concatenated alignment revealed that two Chinese HycuNPV isolates were a novel species of Alphabaculovirus that infected Hyphantria cunea in China. The gene contents indicated significant differences in the HycuNPV genomes between the Chinese and Japanese isolates. The differences included gene deletions, acquisitions and structural transversions, but the main difference was the high number of single nucleotide polymorphisms (SNPs). In total, 10,393 SNPs, corresponding to approximately 8% of the entire HycuNPV-N9 genome sequence, were detected in the aligned reads. By analyzing non-synonymous variants, we found that hotspot mutation-containing genes had mainly unknown functions and most were early expressing genes. We found that the hycu78 gene which had early and late promoter was under positive selection. Biological activity assays revealed that the infectivity of HycuNPV-HB was greater than that of HycuNPV-BJ, and the killing speed of HycuNPV-HB was faster than that of HycuNPV-BJ. A comparison of molecular genetic characteristics indicated that the virulence differences between the two isolates were affected by SNP and structural variants, especially the homologous repeat regions.

Conclusions
The genomes of the two Chinese HycuNPV isolates were characterized, they belonged to a novel species of Alphabaculovirus that infected Hyphantria cunea in China. We inferred that the loss or gain of genetic material in the HycuNPV-HB and HycuNPV-BJ genomes resulted in new important adaptive capabilities to the H. cunea host. These results extend the current understanding of the genetic diversity of HycuNPV and will be useful for improving the applicability of this virus as a biological control agent.
Surgical treatment of acute aortic dissection in a patient with SLE and prior antiphospholipid syndrome on therapy for over 30 years: a case report
Authors: Yamamoto Taira , Endo Daisuke , Shimada Akie , Matsushita Satoshi , Asai Tohru , Amano Atsushi 
Published: May 2022

Abstract
Background
In patients with systemic lupus erythematosus (SLE), lengthy treatment and long-term steroid use are the main risk factors for developing aortic aneurysms or aortic dissections. In patients with cardiac tamponade, hemodynamic collapse may lead to acute renal and hepatic failure.

Case presentation
We report the successful treatment of a 55-year-old woman with SLE since the age of 21. She suddenly felt chest pain approximately 2 weeks before developing fever and vomiting and was admitted to our hospital. Initially, she had severe liver dysfunction and was admitted to the hepatology department, where treatment for fulminant hepatitis was initiated. However, computed tomography (CT) showed an acute aortic dissection (DeBakey type II) and severe bloody pericardial effusion. Therefore, we performed emergency pericardial drainage. Plasma exchange therapy was initiated as emergency aortic surgery was deemed impossible due to impaired liver function tests and coagulation. Ten days later, the patient developed peritonitis due to small bowel perforation, and laparotomy was performed for abscess drainage and perforation closure. She had received steroid pulse therapy at the age of 21. At 40 years of age, she developed deep vein thrombosis due to antiphospholipid antibodies and was prescribed prednisolone. She was ambulatory at 3 months after the onset of acute aortic dissection, and CT revealed a rapidly enlarging true aneurysm in the distal arch. We performed elective aortic surgery. Although there were no antiphospholipid antibodies, surgery could have led to a devastating antiphospholipid syndrome. Therefore, we decided to treat the patient with triple therapy. Methylprednisolone was intravenously administered intraoperatively and at 1 day postoperatively. The patient was discharged without complications after returning to her usual oral prednisolone regimen.

Conclusions
The patient described herein had a systemic circulatory failure due to cardiac tamponade, accompanied by liver failure. This condition is a significant cause of death in patients with aortic dissection-associated SLE and is extremely dangerous. However, multi-specialty intervention helped the patient recover, and she has been attending the outpatient clinic. Aortic surgery requiring hypothermia in SLE patients with antiphospholipid syndrome and a history of thrombocytopenia or thrombosis requires a multi-disciplinary treatment team, including cardiac surgeons and medical experts.
Non-technical skills in pre-hospital care in the Czech Republic: a prospective multicentric observational study (NTS study)
Authors: Peran David , Sykora Roman , Vidunova Jana , Krsova Ivana , Pekara Jaroslav , Renza Metodej , Brizgalova Nikola , Cmorej Patrik Ch. 
Published: May 2022

Abstract
Background
Non-technical skills (NTS) are important for the proper functioning of emergency medical ambulance crews but have hardly been researched in the conditions of clinical pre-hospital care.
The primary objective of this study, therefore, is to describe the use of NTS in practice. The secondary objective is to compare if the performance of NTS varies according to the type of case.

Methods
In this multicentric observational study the modified Team Emergency Assessment Measure (TEAM) score was used to assess the performed NTS of two or more crews on site. The evaluation consisted of leadership, teamwork and task management, rated by a field supervisor.
The study observations took place in real clinical pre-hospital emergency medical cases when two or more crews were dispatched between October 2019 and August 2020. The sample size was determined by researchers prior to the study to at least 100 evaluated events per each of the three participating emergency medical services.
The results are presented as median and interquartile range. The internal reliability, consistency and validity of test items and results were evaluated. The Kruskal–Wallis test and the post hoc Mann-Whitney U test with Bonferroni correction were used for multiple comparisons of three groups.

Results
A total of 359 events were evaluated. Surprisingly, the median value for all eight items was as high as 3.0 with a similar interquartile range of 1.0. There were no differences observed by case type (CPR vs. TRAUMA vs. MEDICAL) except from item 1. A post hoc analysis revealed that this difference is in favour of a higher rated performance of non-technical skills in CPR.

Conclusions
The overall result of the performance of non-technical skills can be regarded as very good and can serve for further evaluations. The crews achieved better parameters of NTS in leadership in resuscitation situations in comparison with general medical events.

Trial Registration
The study is registered at Clinical Trials under the ID: NCT04503369.
Minimizing sample bias due to stigmatized behaviours: the representativeness of participants in a cohort study of alcohol in pregnancy
Authors: Tappin David , Mackay Daniel , Reynolds Lucy , Fitzgerald Niamh 
Published: May 2022

Abstract
Background
Stigmatized behaviours are often underreported, especially in pregnancy, making them challenging to address. The Alcohol and Child Development Study (ACDS) seeks to inform prevention of foetal alcohol harm, linking self-report as well as a maternal blood alcohol biomarker with child developmental outcomes. Samples were requested using passive, generic consent. The success of this approach at minimizing bias is presented comparing characteristics of women who provided samples to those who did not.

Methods
All pregnant women in the study city were sent a Patient Information Sheet (PIS) with their first NHS obstetric appointment letter. The PIS informed them that the NHS would like to take an extra blood sample for research purposes, unless they opted out. Neither the women nor the midwives were informed that the samples might be tested for an alcohol biomarker. This paper examines the extent to which women who provided the extra sample were representative of women where no sample was provided, in terms of routinely collected information: age; body mass index; area-based deprivation; previous pregnancies, abortions and caesarians; smoking status and carbon monoxide level; self-reported alcohol use, gestation and birth weight of their baby. Chi-square and Mann-Whitney U tests were used to compare groups.

Results
3436 (85%) of the 4049 pregnant women who attended their appointment provided the extra sample. Women who did not were significantly younger (p < 0.001), more materially deprived (p < 0.001), and less likely to be considered for intervention based on self-reported alcohol use (p < 0.001). There were no significant differences between the two groups on other routine data.

Conclusions
The use of passive consent without disclosure of the specific research focus resulted in a high level of sample provision. There was no evidence that study blinding was breached, and women who provided a sample were more likely to report alcohol consumption. Passive consent to draw additional blood for research purposes at routine antenatal venipuncture reduced sampling bias compared to asking women to give blood for an alcohol study. This methodology may be useful for other stigmatised behaviours.
Relationship between HER2 overexpression and long-term outcomes of early gastric cancer: a prospective observational study with a 6-year follow-up
Authors: Li Hui , Li Longsong , Zhang Nan , Wang Zixin , Xu Ning , Linghu Enqiang , Chai Ningli 
Published: May 2022

Abstract
Background
Studies have confirmed the prognostic value of the expression status of human epidermal growth factor receptor 2 (HER2) in advanced gastric cancer. However, its role in early gastric cancer (EGC) remains largely unknown. This study explored the association between HER2 overexpression and clinical outcomes of patients with EGC.

Methods
A total of 211 patients who had undergone endoscopic treatment for pN0 EGC were enrolled. The HER2 expression status was assessed using immunohistochemistry (IHC).

Results
The prevalence of HER2 overexpression was 14.2%. HER2 overexpression showed a significant correlation with tumor location (P = 0.033). Multivariate analysis showed that HER2 overexpression was significantly associated with an increased risk of tumor recurrence in pN0 EGC (hazard ratio [HR] = 3.97; 95% confidence interval [CI] 1.30–12.14; P = 0.016) but not overall survival (OS) or disease-specific survival (DSS). Of the included patients, age was associated with OS (HR = 1.11; 95% CI 1.04–1.18; P = 0.002], whereas lymphovascular invasion was significantly associated with poor DSS (HR = 33.66; 95% CI 3.05–371.25; P = 0.004).

Conclusion
This study shows that HER2 overexpression is significantly associated with tumor recurrence in pN0 EGC. Hence, Her2 testing at diagnosis is important and differential treatment and/or follow up strategies for patients with Her2 overexpression may merit future study.
Feasibility of a novel self-collection method for blood samples and its acceptability for future home-based PrEP monitoring
Authors: Cannon Chase A. , Ramchandani Meena S. , Golden Matthew R. 
Published: May 2022

Abstract
Background
Most non-clinic based HIV pre-exposure prophylaxis (PrEP) programs require fingersticks to self-collect blood specimens for laboratory monitoring, a technique that often results in inadequate blood volume for quantitative syphilis and HIV serological testing. We evaluated the acceptability and feasibility of using the Tasso OnDemand™ device as a self-sampling method for PrEP monitoring tests and compared results from samples obtained using the Tasso device to clinician-collected blood samples.

Methods
We enrolled study subjects online and in a sexual health clinic and HIV clinic in Seattle, WA, USA to assess the acceptability of blood self-sampling and preferences for home-based PrEP monitoring. We compared HIV antigen/antibody, quantitative rapid plasma reagin and creatinine results in paired self-collected and clinical specimens collected from a subset of participants.

Results
Of 141 participants, 124 (88%) were interested in collecting samples for PrEP monitoring at home. Among 48 who completed blood collections, 94% found the Tasso device easy to use and 95% felt they could perform self-sampling at home. Of 27 participants who used two devices, 100% collected sufficient blood to perform up to two tests while 33% collected sufficient serum for three tests. Agreement in test results between paired samples was high.

Conclusions
These pilot data suggest that using the Tasso self-collection device is acceptable and could feasibly be used to obtain serum specimens sufficient for guideline-recommended PrEP monitoring, though use of a larger volume device may be preferable.
Memantine for the patients with mild cognitive impairment in Parkinson’s disease: a pharmacological fMRI study
Authors: Kawashima Shoji ,   RCIP-Nagoya Study Group, Shimizu Yoko , Horiba Mitsuya , Ueki Yoshino , Akanabe Ryohei , Kan Hirohito , Kasai Haruaki , Kunitomo Hiroshi , Tanaka Satoshi , Toyota Takenari , Kawashima Shoji , Mizuno Masayuki , Okita Kenji , Matsukawa Noriyuki , Matsukawa Noriyuki 
Published: May 2022

AbstractBackgroundMild cognitive impairment in Parkinson’s disease (PD-MCI) is associated with an increased risk of cognitive decline. PD-MCI is characterized by impairments in executive function and visuospatial recognition. The visuospatial n-back test is useful for assessing both domains. The 0-back test reflects visuospatial recognition, while the 1-back and 2-back tests reflect working memory. Cholinesterase inhibitors are effective in the treatment of PD-MCI and dementia in PD (PDD). Although some studies have reported the efficacy of memantine for PDD, the therapeutic efficacy of memantine in patients with PD-MCI remains uncertain.MethodsThis study aimed to investigate the effects of memantine on brain function in patients with PD-MCI, using a randomized double-blinded crossover protocol and functional MRI (fMRI). Ten patients who completed 16 weeks of follow-up were included. They were randomly assigned to either the memantine or placebo. Patients in the memantine group received 5 mg/day of memantine in the first week. The memantine dose was increased by 5 mg/day per week, until a final dose of 20 mg/day. Patients in the placebo group received the placebo following the same regimen as memantine. After the intervention, they underwent a 4 weeks washout period. Following the crossover protocol, a second intervention was conducted after the washout period. In each intervention, fMRI and neuropsychological tests were performed at the maximum dose period. Comparing the memantine and placebo groups, we investigated difference in the brain regions using the visuospatial n-back test.ResultsThere were no significant regions enhanced by memantine comparing with placebo at any load of n-back tests. In contrast, exploring regions reduced by memantine, we found significant reduction of activations within right lingual gyrus and left superior frontal gyrus in comparison between 2-back and 0-back test. A number of correct answers of the 2-back test and time to complete Trail Making Test-A were worse during memantine intervention.ConclusionsMemantine did not improve visuospatial working memory of the patients with PD-MCI. Treatment for PD should be planned carefully considering the impact on cognitive function. Further study is needed to establish new therapeutic strategy.Trial registrationUMIN000046104. Retrospectively registered.First registration date: 28 Sept 2017.