bluuebunny/crossref_metadata_2025_split huggingface dataset:
Behavior and welfare impacts of water provision via misting in commercial Pekin ducks
Authors: Campbell Dana L M , Belson Sue , Erasmus Marisa A , Lea Jim M 
Published: October 2022

AbstractDucks will access water to maintain feather condition and exhibit natural water-related behaviors such as wet preening. Providing water to ducks commercially is challenging as it may reduce litter and air quality leading to higher duck mortality or illness. This research aimed to measure the behavioral and welfare impacts of water provision via a misting system for commercial Pekin grower ducks in Victoria, Australia. Seven grower flocks were observed (four misted and three nonmisted in open-sided sheds) during May and November 2021. From 26 until 33 d of age, treatment ducks were provided 1 h of misting with shed curtains closed in both treatment and control sheds. At the start and end of the misting application period, external health and welfare measures were taken directly on the ducks via transect walks throughout each shed and catch-and-inspect observations on a sample of 150 ducks from each shed. Video recordings were also made of the misted and nonmisted ducks for 3 h representing time periods prior to, during, and after the 1-h misting across all sheds for all 8 d of the treatment period. Observations were made of all behavior that ducks exhibited at 10-min scan sample intervals across four cameras per shed, totaling 4,198 scans across the seven sheds. General linear mixed models showed the misting application predominantly had impacts on the patterns of behavioral change across the treatment time periods between the misted and nonmisted ducks rather than increasing or decreasing the overall expression of specific behaviors (interaction terms all P ≤ 0.003). The misted ducks increased drinking, tail wagging, and walking, and reduced preening, rooting litter, sitting, and stretching during misting relative to what they showed prior. The nonmisted ducks showed less sitting and more panting during misting relative to prior. Pearson’s Chi-square tests showed some differences between the treatment groups in feather cleanliness on the back and wings (both P &lt; 0.0001), likely resulting from pre-existing differences between sheds in blood from pin feathers. Most welfare indicators showed no positive or negative effect of the misting treatment. These results indicate overhead misting does affect duck behavior to some degree without compromising their welfare, but further research with larger water droplet sizes resulting in greater accumulation of surface water or extended durations of misting may lead to greater effects.
Valuing digital possessions: the role of affordances
Authors: Denegri-Knott Janice , Jenkins Rebecca , Lindley Siân 
Published: October 2022

AbstractIn this article, we introduce an affordance-orientated approach for the study of digital possessions. We identify affordances as a source of value for digital possessions and argue that dominant meaning-orientated approaches do not enable us to fully appreciate these sources of value. Our work recognizes that value is released and experienced in “the doing”—people must do things with digital objects to locate and obtain value in and from them. We distinguish three levels of affordance for digital possessions—low, mid, and high—and introduce the concept of digital incorporation to explain how the three levels of affordances come together, with the individual’s own intentionality to enable the achievement of goals. We draw from postphenomenological interviews with 47 individuals in the UK to provide a possession-based and lived experience approach to affordances that sheds new light on their vital role in everyday life and goals.
The rediscovered Islamic manuscripts of the Cospi Museum in the University Library of Bologna
Authors: Gigante Federica 
Published: October 2022

Abstract
This article reconstructs, by means of unpublished and newly discovered archival sources, the path of the Islamic manuscripts of the Cospi Museum from their entry into the collection of Ferdinando Cospi up to the present day, and identifies them, for the first time, in a group of manuscripts currently held in the University Library of Bologna. Although Islamic manuscripts had made their way to Italy since medieval times and numerous examples may be found in Italian libraries today, very few represent the collection of a single individual and, among these, fewer still have survived as a coherent group. The rediscovered collection of Islamic manuscripts of the Cospi Museum therefore represents a rare survival which provides new insights into early modern collecting practices in Italy, as well as new material through which to explore the history of the interaction between the Islamic world and Italy in the early modern period.
The combination of volumetric arc radiation therapy and boost high-dose rate interstitial brachytherapy for T3N2c tongue cancer: a technical report
Authors: Murakami Naoya , Sakuramachi Madoka , Kashihara Tairo , Chiba Takahito , Nakamura Satoshi , Ono Keisuke , Ueno Takao , Yoshimoto Seiichi , Yoshida Ken , Masui Koji , Akiyama Hironori , Igaki Hiroshi 
Published: October 2022

Abstract
Currently, tongue cancers are primarily managed by surgery, and interstitial brachytherapy is only recommended for a selected group of early state T1-2N0 patients who refuse surgery or are medically inoperable. In this report, a case with T3N2cM0 tongue cancer who has been effectively treated by the combination of concurrent chemoradiotherapy involving volumetric arc therapy and boost high-dose rate interstitial brachytherapy is presented. Of course, surgery remains the main treatment strategy for tongue cancer patients; however, the authors believe that if volumetric arc therapy is carefully planned to reduce the mandible dose as much as possible and high-dose rate interstitial brachytherapy with a mouthpiece that protects the mandible is combined, it is possible to treat T3N2 disease, and this can be considered for patients who want to preserve organ function.
Clinicopathological Features and Outcomes Comparing Patients With Invasive Ductal and Lobular Breast Cancer
Authors: Oesterreich Steffi , Nasrazadani Azadeh , Zou Jian , Carleton Neil , Onger Tiffany , Wright Matthew D , Li Yujia , Demanelis Kathryn , Ramaswamy Bhuvaneswari , Tseng George , Lee Adrian V , Williams Nicole , Kruse Megan 
Published: October 2022

Abstract

Background
There is increasing interest in better understanding the biology and clinical presentation of invasive lobular cancer (ILC), which is the most common special histological subtype of breast cancer. Limited large contemporary data sets are available allowing comparison of clinicopathologic features between ILC and invasive ductal cancer (IDC).

Methods
The Great Lakes Breast Cancer Consortium was formed to compare clinical behavior of ILC (n = 3617) and IDC (n = 30 045) from 33 662 patients treated between 1990 and 2017 at 3 large clinical centers. We used Kaplan-Meier analysis, Cox proportional hazards modeling, and propensity score matching to evaluate treatment differences and outcomes. All statistical testing used 2-sided P values.

Results
Compared with IDC, patients with ILC were more frequently diagnosed at later stages and with more lymph node involvement (corrected P &lt; .001). Estrogen receptor–positive ILCs were of lower grade (grade 1 and 2: 90% in ILC vs 72% in IDC) but larger in size (T3 and 4: 14.3% in ILC vs 3.4% in IDC) (corrected P &lt; .001), and since 1990, the mean ILC size detected at diagnosis increased yearly. Patients with estrogen receptor (ER)–positive ILC underwent statistically significantly more mastectomies compared with ER-positive IDC (57% vs 46%). Using Kaplan-Meier analysis, patients with ER-positive ILC had statistically significantly worse disease-free survival and overall survival than ER-positive IDC although 6 times more IDCs were classified as high risk by OncotypeDx Breast Recurrence Score assay.

Conclusions
This large, retrospective, collaborative analysis with 3 clinical centers identified meaningful differences in clinicopathological features between ILC and IDC, providing further evidence that these are 2 different entities requiring different clinical management.
Online Intervention for Caregivers of Children with Early Traumatic Brain Injury: Pilot Trial
Authors: Maggard Brianna L , Gies Lisa M , Sidol Craig A , Moscato Emily L , Schmidt Matthew , Landry Susan H , Makoroff Kathi L , Rhine Tara D , Wade Shari L 
Published: October 2022

AbstractObjectiveTo assess the feasibility and acceptability of an online parenting-skills program for caregivers of young children with traumatic brain injury (TBI). Positive parenting contributes to recovery following early TBI and social and emotional development in typically developing children. Yet, few interventions have been designed to support psychosocial recovery and subsequent development after early TBI.MethodsThis study protocol was registered with clinicaltrials.gov (NCT05160194). We utilized an academic hospital’s Trauma Registry to recruit caregivers of children, ages 0–4 years, previously hospitalized for TBI. The GROW intervention integrated six online learning modules with videoconference meetings with a coach to review and practice skills while receiving in vivo coaching and feedback. Interactive modules addressed strategies for responsive parenting, stimulating cognition, and managing parenting stress. Enrollment and retention rates served as feasibility metrics and satisfaction surveys assessed acceptability.Results18 of 72 families contacted (25%) consented, and 11 of 18 (61%) completed the intervention and follow-up assessments. All participants rated the intervention as helpful and indicated that they would recommend the intervention to others. All endorsed a better understanding of brain injury and how to optimize their child’s recovery and development. Both coaches rated intervention delivery as comparable to traditional face-to-face treatment.ConclusionsLow levels of uptake and initial engagement underscore the challenges of intervening with caregivers following early TBI, which likely were exacerbated due to the COVID-19 pandemic. High levels of acceptability and perceived benefit support the potential utility of GROW while highlighting the need to improve accessibility and early engagement.
A nationwide evaluation of bevacizumab-based treatments in pediatric low-grade glioma in the UK: Safety, efficacy, visual morbidity, and outcomes
Authors: Green Katherine , Panagopoulou Paraskevi , D’Arco Felice , O’Hare Patricia , Bowman Richard , Walters Bronwen , Dahl Christine , Jorgensen Mette , Patel Pritesh , Slater Olga , Ahmed Rehana , Bailey Simon , Carceller Fernando , Collins Rhiannon , Corley Elizabeth , English Martin , Howells Lisa , Kamal Ahmed , Kilday John-Paul (JP) , Lowis Stephen , Lumb Blanche , Pace Erika , Picton Susan , Pizer Barry , Shafiq Ayad , Uzunova Lena , Wayman Harriet , Wilson Shaun , Hargrave Darren , Opocher Enrico 
Published: October 2022

AbstractBackgroundBevacizumab is increasingly used in children with pediatric low-grade glioma (PLGG) despite limited evidence. A nationwide UK service evaluation was conducted to provide larger cohort “real life” safety and efficacy data including functional visual outcomes.MethodsChildren receiving bevacizumab-based treatments (BBT) for PLGG (2009–2020) from 11 centers were included. Standardized neuro-radiological (RANO-LGG) and visual (logMAR visual acuity) criteria were used to assess clinical–radiological correlation, survival outcomes and multivariate prognostic analysis.ResultsEighty-eight children with PLGG received BBT either as 3rd line with irinotecan (85%) or alongside 1st/2nd line chemotherapies (15%). Toxicity was limited and minimal. Partial response (PR, 40%), stable disease (SD, 49%), and progressive disease (PD, 11%) were seen during BBT. However, 65% progressed at 8 months (median) from BBT cessation, leading to a radiology-based 3 yr-progression-free survival (PFS) of 29%. Diencephalic syndrome (P = .03) was associated with adverse PFS. Pre-existing visual morbidity included unilateral (25%) or bilateral (11%) blindness. Improvement (29%) or stabilization (49%) of visual acuity was achieved, more often in patients’ best eyes. Vision deteriorated during BBT in 14 (22%), with 3-year visual-PFS of 53%; more often in patients’ worst eyes. A superior visual outcome (P = .023) was seen in neurofibromatosis type 1-associated optic pathway glioma (OPG). Concordance between visual and radiological responses was 36%; optimized to 48% using only best eye responses.ConclusionsBBTs provide effective short-term PLGG control and delay further progression, with a better sustained visual (best &gt; worst eye) than radiological response. Further research could optimize the role of BBT toward a potentially sight-saving strategy in OPG.
Angiotensin receptor blockade is associated with increased risk of giant cell arteritis
Authors: Zhao Sizheng Steven , Lyu Houchen , Zeng Chao , Lei Guanghua , Wei Jie , Mackie Sarah L 
Published: October 2022

Abstract

Objectives
Angiotensin II is implicated in GCA pathology. We examined whether the use of angiotensin receptor blockers (ARBs) is associated with GCA risk compared with angiotensin-converting enzyme inhibitors (ACEis) or other antihypertensives.

Methods
We performed a matched cohort study including adults who were initiators of antihypertensives in UK primary care data between 1995 and 2019. Treatment-naïve individuals without prior GCA or PMR were categorized into three groups—ARB initiators, ACEi initiators, or other antihypertensive initiators (beta-blockers, calcium channel blockers, diuretics or alpha-adrenoceptor blockers)—and followed for up to 5 years. Incident GCA was defined using validated Read codes, with age of onset ≥50 years and two or more glucocorticoid prescriptions. Inverse probability–weighted Cox models were used to model outcome risk, adjusting for lifestyle parameters, comorbidities and comedications.

Results
Among &gt;1 million new starters of antihypertensives (81 780 ARBs, 422 940 ACEis and 873 066 other antihypertensives), the incidence rate of GCA per 10 000 patient-years was 2.73 (95% CI 2.12, 3.50) in the ARB group, 1.76 (95% CI 1.25, 2.39) in the ACEi group and 1.90 (95% CI 1.37, 2.56) in the other antihypertensives group. The hazard of GCA was higher in ARB initiators [hazard ratio (HR) 1.55; 95% CI 1.16, 2.06] than initiators of ACEis, but similar between initiators of other antihypertensives and ACEis (HR 1.08; 95% CI 0.87, 1.35).

Conclusions
Initiation of ARBs is associated with a higher risk of GCA compared with ACEis or other antihypertensives. Mechanistic studies of angiotensin receptor biology will provide further clarity for our findings.
New treatment strategies for human epidermal growth factor receptor 2-positive breast cancer in 2023
Authors: Banys-Paluchowski Maggie , Krawczyk Natalia , Stickeler Elmar , Müller Volkmar , Fehm Tanja 
Published: October 2022

Purpose of review
Taxanes in combination with trastuzumab and pertuzumab are the established first-line standard in the treatment of human epidermal growth factor receptor 2 (HER2)-positive metastatic breast cancer. In the last years, several new HER2-targeted therapies, including antibody–drug conjugates (ADCs) and tyrosine kinase inhibitors, have been approved for therapy after trastuzumab or dual blockade. In this review, the current treatment algorithms are discussed, including these new treatment options.

Recent findings
The ADC T-DM1 was the established second-line standard based on the results of the EMILIA trial. Recently, the DESTINY-Breast03 trial compared T-DM1 with the new ADC trastuzumab deruxtecan (T-DXd) in patients with disease progression after treatment with taxanes and trastuzumab. T-DXd was associated with an improved progression-free survival and a trend toward improved overall survival, establishing T-DXd as a new second-line standard. The HER2CLIMB trial demonstrated a significant progression-free survival and overall survival benefit for the tyrosine kinase inhibitor tucatinib in combination with trastuzumab and capecitabine after T-DM1 and trastuzumab/pertuzumab. This benefit was also observed in patients with active brain metastases defining this combination as the preferred second or third-line option in these patients.

Summary
New treatment strategies in HER2-positive metastatic breast cancer have substantially improved the clinical outcome of these patients, including those with active brain metastases.
Chronic Strongyloidiasis in the Primary Care Setting
Authors: Sy Hendrik , Zalcgendler Sara , Edelman Deborah 
Published: October 2022

Abstract

Strongyloides stercoralis can persist for decades in the human host through autoinfection. It can lead to hyperinfection syndrome, which has a high mortality rate and is associated with corticosteroid use. Twelve patients presented to our primary care clinic in New York with eosinophilia and were found to have chronic strongyloidiasis. The patients' characteristics are summarized and the current literature on screening of strongyloidiasis is reviewed. We aim to increase awareness for this condition among primary care providers that care for immigrant populations, especially with widespread use of corticosteroids for the treatment of coronavirus disease 2019.
Disseminated intravascular coagulation in a cohort of adult acute leukemia patients: a single center experience
Authors: Alnuaimy Sarah L. , Shamoon Rawand P. 
Published: October 2022

Objectives
We aimed to detect the incidence of disseminated intravascular coagulation (DIC) in patients with acute leukemia (AL) and find out its association with types of AL and patients’ clinical and pathological parameters.

Methods
In this prospective study, 59 newly diagnosed adults with AL were clinically examined and screened for DIC presentation time. Coagulation tests, including prothrombin time, activated partial thromboplastin time, fibrinogen level, D-dimer, antithrombin, and protein C and protein S levels were all assessed. The International Society for Thrombosis and Hemostasis scoring system was adopted to diagnose overt DIC.

Results
The age of the studied patients ranged from 15 to 81 years with a median of 41 years; male to female ratio was 1.1:1. acute myeloid leukemia (AML) constituted 64.4% of the total cases (38 patients). DIC was detected in 28 patients (47.5%); its incidence was higher in AML than in acute lymphoblastic leukemia (ALL) (52.6% vs. 38.1%). Overt DIC was significantly associated with bleeding manifestations, duration of symptoms, and leukocytosis (P-values = 0.050, 0.044, and 0.003, respectively). Bleeding events were encountered in 50.8% of patients (25 AML and 5 ALL patients). Bleeding was associated significantly with leukocytosis, thrombocytopenia, and low fibrinogen level. Thrombosis was found in two patients (3.4%) at presentation.

Conclusions
Overt DIC was common in patients with AL at presentation, mostly in AML. Routine testing for coagulopathy in newly diagnosed AL patients will possibly aid in improving the overall patients’ survival.
Vascular healing responses to paclitaxel coated balloons or everolimus eluting stents for the treatment of in-stent restenosis. Insights from optical coherence tomography
Authors: McInerney Angela , Salazar Carlos , Pérez-Vizcayno María José , Jimenez-Quevedo Pilar , Jiménez-Valero Santiago , Brugaletta Salvatore , Romaguera Rafael , Nombela-Franco Luis , Travieso-Gonzalez Alejandro , Jerónimo-Baza Adrián , Tirado-Conte Gabriela , Fernández-Ortiz Antonio , Escaned Javier , Alfonso Fernando , Macaya Carlos , Gonzalo Nieves 
Published: October 2022

Background
Treatment of in-stent restenosis (ISR) remains a significant challenge. Current options include repeat stenting or drug-coated balloons. However, there is a paucity of data regarding vascular healing after these strategies. We, aimed to compare optical coherence tomography (OCT)-based vessel healing after treatment with paclitaxel-coated balloons (PCB) or everolimus-eluting stents (EES).

Methods
An OCT substudy (baseline and 6–9 months) of patients from RIBS IV and RIBS V, two prospective multicenter, randomized controlled clinical trials comparing PCB vs. EES in patients with ISR was performed.

Results
Sixty-four patients were included (30 PCB and 34 EES). There were no differences in the baseline or angiographic characteristics between groups. Both groups had the same proportion of drug-eluting and bare-metal stent (BMS) ISR. Baseline OCT analysis did not show differences in the qualitative characteristics of the ISR nor the restenotic tissue burden. Follow-up OCT showed a larger mean lumen area in the EES group (6.03 ± 1.5 vs. 5.24 ± 1.3 mm2; P = 0.043) but no difference in angiographic restenosis (P = 0.66). Percentage tissue coverage was higher with PCB vs. EES (26 ± 13 vs. 19 ± 11%; P = 0.031). EES-treated ISR more frequently had uncovered struts at follow-up [21 (72%) vs. 12 (44%); P = 0.034]. Tissue covering struts more frequently had a high backscatter structure after PCB [21 (78%) vs. 16 (55%); P = 0.07].

Conclusions
Compared with EES, ISR treated with PCB demonstrated more strut coverage with mainly high backscattering tissue. Larger OCT-defined neointimal proliferation in PCB-treated ISR did not translate into higher angiographic restenosis rates.
Effectiveness and safety of acupuncture and moxibustion for chronic prostatitis: A protocol for an overview of systematic reviews and meta-analysis
Authors: Zhou Xingchen , Lv Zhizhen , Hong Shuangwei , Hu Huijie , Tian Yu , Wu Shuang , Wang Kaizheng , Wei Zicheng , Lv Lijiang 
Published: October 2022

Background:
Chronic prostatitis (CP) refers to a disease characterized by local pain and discomfort, urination discomfort, and quality of life. Acupuncture (ACU) and moxibustion are widely used in the treatment of CP, and the curative effect is satisfactory. Several systematic reviews (SRs) and meta-analyzes have reported the effectiveness of ACU and moxibustion in treating patients with CP. However, the evidence is not systematically integrated. This overview aims to integrate and evaluate the reliability of these SRs and the evidence generated from the ACU and moxibustion for CP meta-analysis.

Methods:
We will make a comprehensive retrieval in seven databases as following: Embase, Cochrane Library, Pubmed, Chinese databases SinoMed (previously called the Chinese Biomedical Database), Chinese National Knowledge Infrastructure (CNKI), Chinese Scientific Journals Database (VIP), and Wanfang Data (WF). The time is limited from the construction of the library to May 2021. We will use the Assessment of Multiple Systematic Reviews-2 (AMSTAR-2) tool to evaluate methodological quality. Preferred Reporting Items for Systematic Reviews and Meta-analysis Protocols (PRISMA-P) will be used in the report checklist to assess the quality of reports in the study. The GRADE will be used to evaluate the included SRs and meta-analysis. Our reviewers will conduct SRs, qualification evaluation, data extraction, methodological quality and evidence quality screening in pairs. The outcomes of interest include: NIH-Chronic Prostatitis Symptom Index (NIH-CPSI), effective rate, other CP symptom scales, EPS-WBC, and adverse events. Evidence will be combined based on patient subgroups and results where appropriate.

Results:
The results will be published in a peer-reviewed journal.

Trial registration number:
INPLASY202150018.

Conclusion:
This overview will provide comprehensive evidence of ACU and moxibustion for patients with CP.