bluuebunny/crossref_metadata_2025_split huggingface dataset:
The effects of individual music therapy in nursing home residents with dementia to improve general well-being: study protocol of a randomized controlled trial
Authors: Caramel Vanusa M. Baroni , Steen Jenny T. van der , Vink Annemieke C. , Janus Sarah I.M. , Twisk Jos W.R. , Scherder Erik J.A. , Zuidema Sytse U. 
Published: December 2022

Abstract
Background: Dementia is often associated with Neuropsychiatric Symptoms (NPS) such as agitation, depression, hallucinations, anxiety, that can cause distress for the resident with dementia in long-term care settings and can impose emotional burden on the environment. NPS are often treated with psychotropic drugs, which, however, frequently cause side effects. Alternatively, non-pharmacological treatments approaches can improve well-being and maintain an optimal quality of life (QoL) of those living with dementia. Other outcomes associated to QoL, such as pain, discomfort and sleep disruption are relevant outcomes in trials as well. Music therapy is a non-pharmacological treatment that can reduce NPS and improve wellbeing, and its associated symptoms in dementia.
Methods: The research is conducted at eight facilities of one nursing home organization in the Netherlands. The participants in the intervention group receive 30 minutes of individual music therapy (MT) in their own room by a music therapist twice a week for 12 weeks. The participants in the control group receive 30 minutes of individual attention in their own room by a volunteer twice a week for 12 weeks. Assessments will be done at baseline, 6 weeks and 12 weeks. An independent observer, blinded for the intervention or control condition, assesses directly observed wellbeing (primary outcome) and pain before and after the sessions. Nurses assess other secondary outcomes unblinded, i.e., perceived quality of life and NPS assessed with validated scales. The sleepy duration will be indirectly assessed by a wrist device called MotionWatch. Information about psychotropic drug use is derived from electronic medical chart review.
Discussion: The main purpose of this study is to assess the effects of individual music therapy on directly observed wellbeing controlled for individual attention in nursing home residents with dementia with NPS. The outcomes refer to both short-term and long-term effects consistent with therapeutic goals of care for a longer term. We hope to overcome limitations of previous study designs such as not blinded designs and music facilitators that were not only music therapists but also occupational therapists and nurses. This study should lead to more focused recommendations for practice and further research into non-pharmacological interventions in dementia.
Trial registration: The trial is registered at the International Clinical Trials Registry Platform (ICTRP) search portal in the Netherlands Trial Registration number NL7708, registration date 04-05-2019.
Post craniotomy pain management in Copenhagen rat by intraperitoneal or oral dosage of Tramadol: A comparative evaluation
Authors: Samal Sasmita , Barik Debyashreeta , Jena Sarita 
Published: December 2022

Abstract
Calvarial craniotomy in animal models involves pain and distress. However, due to their immense significance in studying the bone regeneration capabilities of various biomaterials, these animal models are extensively needed in the field of bone tissue engineering. Moderate to severe pain in laboratory animals requires adequate pain management strategies. According to previous studies, the options available for suitable analgesia for rat calvarial craniotomy are very few. For most analgesic treatments, either subcutaneous or intraperitoneal routes of administration are predominantly used. However, both routes require restraining of the animals, which may cause unnecessary pain, distress and suffering. As a well fare measure, we focused on pain management by oral administration of analgesia. In this particular study, which is a sub-study of a major experiment on bone regeneration with different polymeric scaffold materials, we have compared the analgesic efficacy of intraperitoneal (I/P) and oral administration of tramadol (10mg/kg) over a period of 96h post-surgery in rat craniotomy models. The focus of our study is to evaluate the potential pain reduction efficacy of orally administered Tramadol without any restraining involved. We have used various non-invasive methods to assess the pain-alleviating efficacy of tramadol administered through different methods.
Impact of the combined effect of diode laser (976 nm) and Sodium Fluoride gel in the Treatment of Dentin Hypersensitivity: An Ex Vivo Study
Authors: Siddig Reem Esam , Ellateef Abd Ellateef Abbass Abd , Awooda Elhadi Moheildin 
Published: December 2022

Abstract

Background:Dentin Hypersensitivity (DH) is a painful condition with challenging treatment options.Aims:This study aims to evaluate the effects of the diode laser on dentinal tubules by a diode laser, as well as the mechanism of the diode laser (976 nm) and chemical agent (sodium fluoride gel) in occluding the dentinal tubules in vitro.Materials and Methods:Ten extracted human premolars were utilized in the current in vitro experimental SEM study. Using a diamond saw at a coronal dentin, disks of 1.0 mm thickness were cut perpendicular to the long axis of each tooth. Ten dentin disks were selected, and each disk was divided into four equal parts, pre-treated with Ethylene Diamine Tetra Acetic Acid 17%, then divided into four groups; (Group 1) control, (Group 2) diode laser 976 nm of 1 watt, (Group 3) Sodium fluoride only and (Group 4) combined laser and sodium fluoride varnish. The samples were analyzed using a scanning electron microscope at different magnifications (100µm, 50µm, 20µm, and 2µm). ANOVA Test was used to compare the diameter of the tubules and area between the four groups, with the level of significance set at a p-value of ˂0.05.Results:Group 1 (control, no treatment) showed an opening of all the dentinal tubules. Both samples of Group 2 (laser) and Group 3 (Sodium Fluoride) demonstrated partial occlusion and narrowing of most dentinal tubules, while Group 4 (combined) showed total occlusion of almost all the dentinal tubules. There is a statistically significant difference between the four groups regarding the diameter of the dentinal tubules and the area of 5×5 mm diameter on the dentin disks.Conclusions:The combination of Diode laser (976 nm) 1W and sodium fluoride varnish significantly affected the dentinal tubule occlusion, thus preventing DH.
TMEM100 Regulates Neuropathic Pain by Reducing the Expression of Inflammatory Factors
Authors: guo zhaoyang , Guo Zhu , Fan Zuoran , Shen Nana , Qi Xiaoying , Ma Yuanye , Zhu Youfu , Wu Xiaolin , Chen Bohua , Xiang Hongfei 
Published: December 2022

Abstract
There is no effective treatment for peripheral nerve injury-induced chronic neuropathic pain (NP), which profoundly impacts the quality of life of those affected. Transmembraneprotein100 (TMEM100) is considered to be a pain regulatory protein and is expressed in the dorsal root ganglion (DRG) of rats. However, the mechanism of pain regulation and the expression of TMEM100 following various peripheral nerve injuries are unclear. In this study, we constructed two pain models of peripheral nerve injury: tibial nerve injury (TNI) and chronic constriction injury (CCI). This study found that the Paw Withdrawal Mechanical Threshold (PWMT) and Paw Withdraw Thermal Latency (PWTL) of the rats in the two pain models decreased significantly, and the expression of TMEM100 in the DRG of two groups also decreased significantly. Furthermore, the decrease in the CCI group was more obvious than in the TNI group. There was no significant statistical significance (P > 0.05). We constructed an adeno-associated virus 6 (AAV6) vector expressing recombinant fluorescent TMEM100 protein and injected it into the sciatic nerve (SN) of two pain models: CCI and TNI. PWMT and PWTL were significantly increased in the two groups, along with the expression of TMEM100 in the spinal cord and DRG. It also significantly inhibited the activation of microglia, astrocytes, and several inflammatory mediators (TNF- α, IL-1 β, and IL-6). In summary, the results of this study suggested that TMEM100 might be a promising molecular strategy for the treatment of NP, and its anti-inflammatory effects might play an important role in pain relief.
A lightweight neural network designed for fluid velocimetry
Authors: Manickathan Lento , Mucignat Claudio , Lunati Ivan 
Published: December 2022

Abstract
We devise a novel Lightweight Image Matching Architecture (LIMA), which is designed and optimized for Particle Image Velocimetry (PIV). LIMA is a convolutional neural network (CNN) that performs symmetric image matching and employs an iterative residual refinement strategy, which allows us to optimize the total number of refinement steps to balance accuracy and computational efficiency. The network is trained on kinematic datasets with a loss function that penalizes larger gradients. We consider a six- (LIMA-6) and a four-level (LIMA-4) version of the network and demonstrate that they are considerably leaner and faster than a state-of-the-art network designed for optical flow (PWCIRR). LIMA-6 reconstructs the velocity field from synthetic and experimental PIV images with an accuracy comparable or superior both to PWCIRR as well as to state-of-the-art cross-correlation methods (i.e., a commercial implementation of WIDIM). Although less accurate, LIMA-4 allows a significant reduction of the computational costs with respect to any other method considered. All CNNs prove more robust than WIDIM with respect to particle loss and allow effective error reduction by increasing the particle seeding density. Thanks to reduced computational cost and memory requirement, we envision the deployment of LIMA on low-cost devices to provide affordable, real-time inference of the flow field during PIV measurements.
Anti relaxation coating induced velocity dependent population alignment in electromagnetically induced transparency
Authors: Sharma Nayan , Singh Ranjit Kumar , Subba Indra Hang , Chatterjee Souvik , Tripathi Ajay 
Published: December 2022

Abstract
In an uncoated vapor cell, transmission spectra obtained for electromagnetically induced transparency (EIT) for D2 line of 87Rb shows asymmetry and (or) absorption in the presence of magnetic field. In this study, complete conversion from asymmetry/absorption to transmission is found by using octadecyltrichlorosilane (OTS) as an anti-relaxation coating. The experimental results were interpreted as velocity dependent population alignment in the ground states induced by the coating which results in the conversion from absorption to transmission. A simple theoretical model based on density matrix is presented for qualitative interpretation of the results.
Impact of Covid-19 lockdown on trap fishery in Olaikuda Region of Palk Bay, South India
Authors: Mariasingarayan Yosuva , Singaravelu Velvizhi , Alagarsamy Sakthivel , Julius Arockia Kevikumar , bai Abdul Salam Kather 
Published: December 2022

Abstract

The present work analysed the fish catches and associated prices of trap fisheries during the regular and COVID-19 lockdown along the Olaikuda fishing village, Palk Bay region. The main target fishery in this region is coral associated fishes. A total of 713 kg of fishes harvested from the trap for eight months of study. The higher and lower average catch was recorded in May and April during 2020 lockdown respectively. But in the regular fishing months, the higher and lower average catch was recorded in July and March 2020 respectively. The total value of harvested fishes during the regular fishing months was ₹ 66,137 and in lockdown months ₹ 54,583 with the cumulative value of ₹ 1,20,720 as against the operation cost of ₹70,750 excluding the cost of craft. Thus, COVID-19 lockdown influenced the price of export quality fishes belonging to the family Scaridae due to which the fishes were sold at lower prices leading to low income of trap fishers. Data on this type of work is not available to compare the present situation. Therefore, long term study will be conducted in different trap fishing areas to compare the catch data along with market value for better understanding.
The Opposite Effects of Estradiol and Progesterone on Woman’s Disgust Processing
Authors: Liu Mei , Zhang Xia , He Zhengming , Liang Yuan , Zou Bihong , Gu Simeng , Wang Fushun 
Published: December 2022

Abstract
Ovarian hormones play a critical role in emotion processing, which might be the major reason for the high rates of major depressive disorders in women. However, the exact roles of estradiol and progesterone on the basic emotions remain unclear. To this end, we performed a behavioral and an rs-fMRI study. Experiment 1 examines the specific influence of these two ovarian hormones on pathogen disgust and moral disgust processing across the menstrual cycle using the single category implicit association test (SC-IAT) and explicit measures of disgust intensity task. In experiment 2, we used the amygdala, dorsal anterior cingulate cortex(dACC), and insula as a seed to explore the menstrual cycle effects on intrinsic connectivity networks related to emotion processing. The behavioral results showed that women during the luteal phase had higher D scores and shorter response times (RTs) to disgust stimuli (both for pathogen disgust and moral disgust stimuli) compared to the menses phase and follicular phase. Instead, women during the follicular phase had fewer disgust feelings and longer response time (RTs) to pathogen stimuli compared to the menses phase and luteal phase, but this effect was moderated by the intensity of the stimuli. Furthermore, there was no difference in subject moral disgust feelings between the three cycle phases. The rs-fMRI studies showed that luteal phase women have higher functional connectivity in the salience network compared to the follicular phase. And compared to the menstrual phase, follicular phase women have lower functional connectivity in the anterior insula and amygdala. In summary, the more negative attitude to disgust stimuli and the enhanced functional connectivity of the salience network shown during the luteal phase may be associated with high progesterone levels, whereas the lower disgust feelings and reduced functional connectivity of the amygdala shown during the follicular phase may be associated with high estradiol levels.
Visual tracking of viral infection dynamics reveals the synergistic interactions between cucumber mosaic virus and broad bean wilt virus 2
Authors: Kwon Min-Jun , Kwon Sun-Jung , Kim Myung-Hwi , Choi Boram , Byun Hee-Seong , Kwak Hae-Ryun , Seo Jang-Kyun 
Published: December 2022

Abstract
Cucumber mosaic virus (CMV) is one of the most prevalent plant viruses in the world, and causes severe damage to various crops. CMV has been studied as a model RNA virus to better understand viral replication, gene functions, evolution, virion structure, and pathogenicity. However, CMV infection and movement dynamics remain unexplored due to the lack of a stable recombinant virus tagged with a reporter gene. In this study, we generated a CMV infectious cDNA construct tagged with a variant of the flavin-binding LOV photoreceptor (iLOV). The iLOV gene was stably maintained in the CMV genome after more than four weeks of serial passages between plants. Using the iLOV-tagged recombinant CMV, we visualized CMV infection and movement dynamics in living plants in a time course manner. We also examined whether CMV infection dynamics is influenced by co-infection with broad bean wilt virus 2 (BBWV2). Our results revealed that both the viruses infected the same cells, with BBWV2 having a synergistic effect on the dynamics of CMV infection. Our findings suggest that iLOV-tagged CMV is a useful tool for in planta visual tracking of the virus in functional analyses of viral and host genes involved in viral infection and pathogenicity.
Comprehensive RNA-Seq-based study and metabolite profiling to identify genes involved in podophyllotoxin biosynthesis in Linum album Kotschy ex Boiss. (Linaceae)
Authors: Danaeipour Zahra , Garoosi Ghasemali , Tohidfar Masoud , Bakhtiarizadeh Mohammad Reza , Mirjalili Mohammad Hossein 
Published: December 2022

Abstract
Linum album is a well-known rich source of anticancer compounds, i.e., podophyllotoxin (PTOX) and other lignans, which play an important role in the plant defensive system. In the present study, the RNA-Seq data of flax (L. usitatissimum) under aluminum toxicity, zinc and K+ deficiency, drought stress, ABA, and Fusarium treatments were analyzed to identify common DEGs and then examined in L. album, using HPLC and qRT-PCR. Commonly DEGs analysis identified EP3 with a significant increase in all stresses. The highest expression increase was found for laccase )LAC11(, lactoperoxidase )POD(, 4-coumarate-CoA ligase )4CL(, and secoisolariciresinol (SECO) dehydrogenase )SDH(. A quantitative expression showed that the SDH gene had an increasing trend in L. album root and its expression trend was different in the plant shoot. The gene expressions of deoxyPTOX synthase (2-ODD), excluding drought stress, and 5'-desmethyl-yatein O-methyltransferase (OMT1) revealed a rising trend. HPLC analysis confirmed the results of gene expression. SECO content increased under drought stress, and 6-metoxyPTOX content was more than PTOX in both tissues. Identified modifications of critical genes related to PTOX biosynthesis in response to multiple stresses can provide a baseline for improving PTOX content.
Fabrication of a liquid scintillator based on 7-Diethylamino-4- methylcoumarin for radiation detection
Authors: Min Su Jung , Park Yong Dae , Yoon Seon Kwang , Lee Chae Hun , Seo Bum Kyoung , Cheong Jae Hak , Roh Changhyun , Hong Sang Bum 
Published: December 2022

Abstract
Organic scintillation detectors are widely used to measure the presence or absence of radiation. With these devices, there are advantages in that they are easy to manufacture, large in size, and have a short fluorescence decay time. However, they are not suitable for gamma measurements because they are composed of a low-atomic-number material. In this regard, alternative materials for the secondary solute used in basic organic scintillators have been investigated, and the applicability of alternative materials, the detection characteristics, and neutron/gamma identification tests were all assessed. 7-Diethylamino-4-methylcoumarin (DMC), selected as an alternative material, is a benzopyrone derivative in the form of colorless crystals with high fluorescence, a high quantum yield in the visible region, and excellent light stability. In addition, it has a large Stokes shift, and solubility in a solvent is good. Through an analysis in this study, it was found that the absorption wavelength range of DMC coincides with the emission wavelength range of PPO, which is the primary solute used with DMC. Finally, it was confirmed that the optimal concentration of DMC was 0.08 wt%. As a result of performing gamma and neutron measurement tests using a DMC-based liquid scintillator, it was found to perform well (FOM = 1.42) compared to a commercial liquid scintillator, BC501A.
Association of A1AT genetic polymorphism and NSCLC: a case- control study in Egyptian population
Authors: El-dawa Aliaa , Elsaid Afaf , refaat Sherif , El-khawaga omali 
Published: December 2022

Abstract
Lung cancer mortality is higher than other forms of cancer. Genetic tendency in cancer sufferers has long been known. Given the link between AATD and numerous lung disorders, it is worth investigating if this genetic trait is linked to a higher risk of developing LC, as the lung is the most afflicted organ in individuals with severe AATD. Methods: a case-control study was performed on 124 (NSCLC) cases with 124 healthy controls from 2021 to 2022, in the oncology center of Mansoura university. Peripheral blood was used to obtain genomic DNA. ARMS-PCR was used to genotype SNPs and other chemical parameters. Result: Molecular study for A1AT rs17580 and rs8004738 genotypes showed that NSCLC cases were significantly associated with a higher proportion of mutant S (T) and mutant Z (A) allele (p = 0.042, 0.041 respectively). Different A1AT genotypes MS, MZ, SS, SZ, ZZ investigated no significant association with NSCLC or NLR. Conclusion: significant impact of S and Z alleles on NSCLC risk and potential benefit for identifying and protecting these individuals who may be vulnerable to carcinogens.
Predicting the potential suitable distribution area of Emeia pseudosauteri in Zhejiang Province based on the MaxEnt model
Authors: Li Sheng , Wang Zesheng , Zhu Zhixin , Tao Yizhou , Xiang Jie 
Published: December 2022

Abstract
Human activities, including urbanization, industry, agricultural pollution, and land use, have contributed to the increased fragmentation of natural habitats and decreased biodiversity in Zhejiang Province as a result of socioeconomic development. Numerous studies have demonstrated that the protection of ecologically significant species can play a crucial role in restoring biodiversity. Emeia pseudosauteri, for instance, is recognized as an outstanding environmental indicator species, umbrella species, and flagship species due to its distinctive biological characteristics and high public appeal. Assessing and projecting the potentially suitable regions of Emeia pseudosauteri in Zhejiang Province can aid in the conservation of the province's biodiversity in its entirety. In this study, the MaxEnt ecological niche model was utilized to assess the habitat suitability of Emeia pseudosauteri in Zhejiang Province and comprehend the potential distribution pattern and environmental characteristics of suitable habitats for Emeia pseudosauteri in Zhejiang Province. (1) The mean value of area under the receiver operating characteristic (ROC) curve (AUC) for the MaxEnt model was 0.985, with a standard deviation of 0.011, and the model prediction results were excellent and credible. (2) Among the 11 environmental variables used in modeling, seasonal changes in temperature, elevation, and distance to rivers contributed more to the prediction of the potentially suitable distribution area of Emeia pseudosauteri. (3) According to the results of the comprehensive prediction model, Emeia pseudosauteri was mainly distributed in Zhejiang Province in areas with elevations of 50–300 m, seasonal changes in temperature of 7.7°C to 8°C, and proximity to rivers. This study provides a scientific basis for the future conservation of Emeia pseudosauteri habitat and population rebreeding and offers corresponding suggestions for the resource management and industrialization of Emeia pseudosauteri.
Metabolomics Study of Patients with Chronic Heart Failure Based on Nuclear Magnetic Resonance
Authors: Juan Sun , MaheMuti Ailiman , Abudouwayiti Aihaidan , Abuduhalike Refukaiti 
Published: December 2022

Abstract
Objective: To determine the metabolic changes accompanying heart failure and identify novel diagnostic biomarkers.
Methods: Plasma samples were collected from 100 healthy controls and 200 heart failure patients who were admitted to the First Affiliated Hospital of Xinjiang Medical University from January 2021 to January 2022. The samples were analyzed by proton nuclear magnetic resonance. The differential metabolites among the three groups were identified by principal component analysis and orthogonal partial least squares discriminant analysis(OPLS-DA), and the correlation between metabolite concentration and heart failure was evaluated.
Results: Compared to the healthy control group, the serum levels of 3-hydroxybutyrate, alanine, citrulline and acetone were significantly higher in the HFmrEF and HFrEF groups (P<0.05). Furthermore, these metabolites were present in significantly higher concentrations in the HFrEF compared to the HFmrEF group (P<0.05).
Conclusion: The heart failure patients have a distinct metabolome, and 3-hydroxybutyric acid, alanine, citrulline and acetone are potential biomarkers of cardiac dysfunction. Metabolomics can provide a reliable diagnostic method for heart failure.