bluuebunny/crossref_metadata_2025_split huggingface dataset:
Determination of the antimicrobial susceptibilities of Canadian isolates of Haemophilus influenzae, Streptococcus pneumoniae and Moraxella catarrhalis
Authors:   the Canadian Antimicrobial Study Group, Blondeau J. M. , Suter M. , Borsos S. 
Published: July 2002

Abstract
The susceptibility of Canadian isolates of three respiratory tract pathogens (Haemophilus influenzae,Moraxella catarrhalis and Streptococcus pneumoniae) to several antimicrobial agents were tested by two different methods. β-Lactamase was produced by 68/211 (32.2%) of H. influenzae isolates and 64/75 (85.3%) of M. catarrhalis isolates. For S. pneumoniae, 19/156 (12.2%) isolates were resistant to penicillin (MIC ≥0.12 mg/L) and two isolates had MICs of 1.5 mg/L. For some combinations of agents and organisms, different methods gave different values for the proportion of isolates susceptible. Regardless of methodology, for H. influenzae, the most active antimicrobials based on proportion of strains susceptible were ciprofloxacin (100%) and cefpodoxime (98.5- 100%). For M. catarrhalis, the most active agents were azithromycin, cefaclor, cefixime, cefpodoxime, cefuroxime, ciprofloxacin, clarithromycin and loracarbef (100% each); the least active was ampicillin. Against penicillin-sensitive and -resistant pneumococci, the activity was not significantly different for azithromycin and clarithromycin (93.4- 100%) and ciprofloxacin (MIC 90 2.0 and 1.5 mg/L, respectively) but was different for cefuroxime (99.3% and 31.6%, respectively), cefaclor (MIC 90 0.75 and ≥256 mg/L, respectively), cefpodoxime (MIC 90 0.047 and 1.5 mg/L, respectively) and loracarbef (MIC 90 0.75 and ≥256 mg/L, respectively). This study indicates the increasing incidence, in Canada, of β-lactamase resistance in H. influenzae and M. catarrhalis and penicillin resistance in S. pneumoniae.
Multistep nucleus formation and a separate subunit contribution of the amyloidgenesis of heat‐denatured monellin
Authors: Konno Takashi 
Published: July 2002

AbstractMonellin (MN) is a sweet‐tasting plant protein known to form fibrous aggregates in the heat‐denatured state. Here the amyloid‐type aggregation process of MN is extensively characterized. The amyloidgenesis was initiated in a highly denatured state of MN. A seeding effect of skipping a lag phase of the amyloid formation kinetics established a nucleation‐dependent aggregation mechanism. A finely controlled experimental protocol revealed an additional prenucleus stage preceding the maturation of the nucleus, indicating that the initial lag phase is composed of multiple conformational events. The results obtained for the aggregation properties of the separate A and B subunit chains of MN and a recombinant single‐chain MN suggest that the B chain exclusively contributed to the amyloid‐type aggregation. These findings suggest a scheme for the amyloidgenesis of MN and their subunits, and provide a unique model of amyloidgenesis that is regulated by the subunit composition of protein.
PENGARUH METODE LATIHAN POWER TERHADAP KECEPATAN TENDANGAN DOLLYO CHAGI PADA ANGGOTA TAEKWONDO SIPJIN KABUPATEN SUKABUMI TAHUN 2019
Authors: Fauzi Hamad , Septiadi Firman , Maulana Firman 
Published: August 2022

This study aims to determine the effect of power training on the speed of the Dolly Chagi kick in the Sipjin taekwondo member Sukabumi Regency. The importance of the role of the power training method to the speed of the Dolly Chagi kick in taekwondo kicks. This research uses quantitative methods (pre-experimental, pretest-posttest control group design). This study population is a member of the Sipab taekwondo Sukabumi Regency, a population of 25 people taken by 20 people. The sample of this study was all members of taekwondo with purposive sampling technique, which is the technique of determining the sample with certain considerations. The instruments used in this study include: (1) training program, (2) dollyo chagi kick speed test. Based on the results of calculations using the normality test, F-test and T-test analysis techniques. the F count result is greater than the F table, i.e. F count (2.39) and F table (2.98). and T arithmetic greater than T table that is T arithmetic (2,934) and T table (1,812). based on a significance level of 0.05, Ha was accepted, meaning that there was an influence of the power training method on the speed of the Dolly Chagi kick on members of the Sipjin Taekwondo Sukabumi Regency in 2019
PENINGKATAN DAYA SAING UMKM MINUMAN OLAHAN KOPI MELALUI STRATEGI BRANDING (STUDI KASUS: LASKAR KOPI ARJASARI)
Authors: Lukito Wahyu 
Published: August 2022

ABSTRAK. Jumlah UMKM di wilayah Bandung yang semakin bertambah, khususnya di bidang minuman olahan kopi, membuat persaingan antar para pelaku usaha meningkat. Persaingan tersebut menimbulkan masalah bagi UMKM untuk berkembang. Selain mengalami salah satu permasalahan dari eksternal tersebut, UMKM pun memiliki permasalahan internal. Mayoritas permasalahan internal yang dialami UMKM adalah dalam hal pemasaran. Dari permasalahan tersebut dibutuhkan sebuah penelitian untuk menganalisis dan merumuskan strategi branding lewat identitas visual, untuk meningkatkan daya saing UMKM minuman olahan kopi yang menjadi objek penelitian. Studi kasus dalam penelitian ini adalah Laskar Kopi Arjasari. Penelitian ini menggunakan pendekatan fenomenologi kualitatif, untuk mengetahui bagaimana kondisi operasional dan faktor-faktor yang mempengaruhi Laskar Kopi Arjasari dalam menjalankan usahanya, dengan melakukan analisis internal dan ekternal perusahaan. Diharapkan dengan dilakukannya studi analisis ini para stakeholder terkait, baik pelaku usaha maupun desainer, menjadikan penelitian ini sebagai referensi dalam menentukan strategi branding yang tepat, efektif dan efisien bagi UMKM. Strategi yang dapat dilakukan adalah fokus diferensiasi. Hasil yang dicapai, Laskar Kopi Arjasari dapat berfokus pada pengembangan value produk dan mengoptimalkan brand identity yang dimiliki. Brand identity Laskar Kopi Arjasari dapat dioptimalkan dengan cara mengimplementasikannya pada media-media promosi, baik media promosi offline maupun media promosi online.
The teachers' perceptions of the developed physics curriculum for the tenth grade in public schools affiliated with the capital Amman of the e-learning method in light of the Corona pandemic
Authors: Qadi Lina 
Published: August 2022

This study aims to detect the perceptions of teachers of the developed physics curriculum for the tenth grade of basic school in the government schools of the capital amman of the e-learning method in light of the Corona pandemic. The study used the descriptive survey method. To achieve the objectives of the study, a questionnaire consisting of (17) items was prepared. The study sample consisted of (158) male and female teachers in Jordan. The results showed that the teachers' perceptions of the developed physics curriculum for the tenth primary grade in the public schools affiliated with the Qweismeh County for the e-learning method in light of the Corona pandemic were high. The results also showed that there were no statistically significant differences in the perceptions of the teachers of the developed physics curriculum for the tenth primary grade in the government schools affiliated with the capital Amman of the e-learning method in light of the Corona pandemic due to the variable of gender and scientific qualification.
درجة ملاءمة البيئة التعليمية لدمج الطلاب ذوي الإعاقة في المدارس الحكومية بمحافظة غزة
Authors: زيديـة فـرح 
Published: August 2022

هدفت الدراسة لتعرف على درجة ملاءمة البيئة التعليمية لدمج الطلبة ذو الاعاقة في المدارس الحكومية بمحافظة غزة من وجهة نظر المرشدين التربويين، ولتحقيق هذا الهدف تم استخدام المنهج الوصفي بأسلوبه التحليلي، وقد استخدمت الاستبانة كأداة الدراسة على جميع المرشدين التربويين في مديرتي التعليم شرق وغرب غزة كمجتمع الدراسة بمجموع (145) كلا الجنسين للعام الدراسي 2017-2018.
توصلت الدراسة إلى أن درجة تقدير ملاءمة البيئة التعليمية بما يتعلق بإدماج الطلبة ذوي الإعاقة كبيرة، إذْ حصل المجال الاجتماعي حصل على المرتبة الأولى بوزن نسبي (75.13%)، وجاء المجال الأكاديمي الذي حصل على وزن نسبي (71.06%) في نهاية ترتيب المجالات؛ وأشارت نتائج الدارسة بأن نقص الأدوات المساعدة والتمويل المقدّم للطلبة ذوي الإعاقة هي من أبرز المعوقات التي تحوّل دون إدماج الطلبة، وسرد المرشدون العديد من التوصيات منها تنفيذ تدريبات لدعم الكادر البشري داخل المدرسة لفهم التطبيق لممارسات الدمج للطلبة ذوي الإعاقة. وعليه فإن أهم توصيات البحث هي توسيع قاعدة الخدمات المقدمة الداعمة للطلبة ذوي الإعاقة، إضافة إلى التركيز على ترسيخ البيئة الاجتماعية المدرسية المرحبة والخالية من العنف والعزل بين الطلبة بعضهم البعض لما لها من تأثيرات فعالة على أقرانهم الطلبة من ذوي الإعاقة من زيادة في إنجازهم الأكاديمي.
PENGETAHUAN PERAWAT DENGAN PENERAPAN STANDAR OPERASIONAL PROSEDUR MANAJEMEN NYERI DI RUMAH SAKIT MITRA MEDIKA TANJUNG MULIA MEDAN
Authors: Yunita Sukma , Pasaribu Masdalifa , Sharfina Dirayati , Juliani Lubis Ade 
Published: August 2022

Nyeri merupakan bagian dari pengalaman hidup sehari-hari. Nyeri mempunyai sifat yang unik, karena di satu sisi nyeri menimbulkan derita bagi yang bersangkutan, tetapi disisi lain nyeri juga menunjukkan suatu manfaat. Nyeri bukan hanya merupakan modalitas sensori tetapi juga merupakan suatu pengalaman.penelitian ini bertujuan untuk mengetahui hubungan pengetahuan perawat dengan penerapan standart operasional prosedur manajemen nyeri di rumah sakit mitra medika tanjung mulia medan .desain yang digunakan dalam penelitian ini deskriftif korasional dengan pendekatan closs sectional. Sampel penelitian ini adalah perawat IGD yang berjumlah 25 orang yang diambil berdasarkan total sampling. Instrument yang digunakan adalah kuesioner yang terdiri dari kuesioner pengetahuan dan kuesioner SOP manajemen nyeri. analisa hasil penelitian dengan uji shi-quare. Hasil penelitian menunjukkan terdapat hubungan pengetahuan dan sop manajemen nyeri dengan nilai sig-p=0,004 atau <nilai- α=0,05 . disarankan kepada perawat untuk menjaga keselamatan pasien dengan menerapkan SOP dalam setiap tindakan yang dilakukan oleh perawat.
Chronische Blepharitis
Authors: Dietrich-Ntoukas Tina 
Published: August 2022

ZusammenfassungBlepharitis ist eine häufige entzündliche Erkrankung der Augenlider einschließlich des Lidrandes, die bei Erwachsenen und Kindern auftreten und schwere Symptome hervorrufen haben kann. Je
nach anatomischer Lokalisation kann die Blepharitis in anteriore und posteriore Formen eingeteilt werden. Die Pathogenese der chronischen Blepharitis ist noch nicht vollständig geklärt, es
wird jedoch ein multifaktorielles Krankheitsgeschehen vermutet. Die Erkrankung stellt eine therapeutische Herausforderung dar.
Gran Estado Falcón Zulia, Venezuela (1881-1890). La Década del Silencio, una perspectiva histórica cultural
Authors: Boscán-Fernández Jairo Enrique , Guanipa-de-Dávila Xiomara Emilia 
Published: August 2022

Introducción: A finales del siglo XIX, la pérdida y posterior recuperación de la autonomía del estado Zulia (Venezuela), generó un debate entre centralistas y autonómicos digno de análisis historiográfico Objetivo: Interpretar el proceso histórico-cultural acontecido en el occidente venezolano durante el periodo 1881-1890, con la creación del Estado Falcón-Zulia por parte del presidente Antonio Guzmán Blanco; se reconocen las circunstancias que justifican la pasividad de los zulianos ante una decisión que atropellaba su autonomía regional. Metodología: Representa una investigación documental, sustentada en la revisión de fuentes primarias correspondientes al Archivo Histórico del Estado Zulia, y referencias secundarias que esclarecen el pensamiento de los hombres letrados y económicamente privilegiados del siglo XIX. Resultados y discusión: Inicialmente los zulianos toleraron pasivamente la medida integracionista, sin embargo, 9 años después se propicia un movimiento por la recuperación de la autonomía pérdida, materializándose en 1890 la decisión formal de devolverle al Zulia su condición de estado soberano. Esa tardía reacción se corresponde con el respeto que la dirigencia marabina expresaba hacia la figura de Guzmán Blanco por su condición de dirigente garante de la estabilidad política y el desarrollo comercial nacional; en contraposición a las características de los caudillos que lo suceden en el poder central, quienes comienzan a interferir con lo que había sido en la década de 1880 un proceso autónomo en relación al desarrollo comercial regional. Conclusiones: El capítulo de historia regional analizado y la resolución del conflicto planteado significaron la reafirmación del exacerbado regionalismo que identifica al pueblo zuliano.
Precautionary measures for infectious diseases in the light of Islamic Shariah (An Analytical study)
Authors: Aziz Dr. Asma , U dduja Kashaf , Naz Shama 
Published: August 2022

Islam is not only a religion of religious adulation but also provides a complete and sufficient knowledge on all stages of human life. It has provided us complete knowledge on maintenance of human’s health and purifications. Furthermore, it has guided us to abstain from all the harmful things which causes damage to human’s life. Among all the sicknesses, infectious diseases cause the most hazardous effect on mankind all around the world. In recent COVID-19 pandemic situation, World Health Organization (WHO) has specified the precautionary measures to ensure the safety of human health. According to the guidelines instructed by World Health Organization, Government and health specialists around the world take some initiatives to control the extent of infectious virus. It is considered to be the most contagious when people are most symptomatic. In general, there are few or no treatment options for viral diseases. There are some precautions to be taken to overcome the pandemic. These steps include; frequently cleaning of hands with soap or alcohol based sanitizer, covering nose and mouth when coughing or sneezing, keeping distance from persons with cold and flu. Islam is a complete code of life for mankind. It strongly emphasis on the precautions and cleanliness. Hence in present-day condition the guidelines provided by health organizations are already mentioned in Islamic Shariah and was followed by ?a??bahs and Islamic authorities. No doubt we must consider Islamic teachings for the betterment of society. Firstly, as a Muslim it is important to seek Allah’s protection and being a responsible citizen, it is obligatory to act upon the precautions specified by the health specialists and strictly follow the rules indicated by Government. In this article, the traditions and teachings of Holy Prophet SAW regarding the health, cleanliness and religious rituals are discussed along with the safety measurements provided by WHO which includes cleanliness, better healthy food, quarantine, and social distancing etc. will be discussed thoroughly.
Impact of IL-10-1082A\G promoter gene polymorphism and production in lung cancer patients
Authors: Nomi Aqeel Wadi , Darweesh Mayyada F. 
Published: August 2022

Lung cancer a deadliest malignant disease , Cytokines play a critical role in regulating host immune response toward cancer and determining the overall fate of tumorigenesis. So this study aimed to investigate the impact gene variation of IL-10 promotor region on production of IL-10 cytokine and their effect on lung cancer outcome. The aim of this study is the detection of IL-10-1082A\G polymorphism and IL-10 serum level with it correlation to progression of disease. A Case-control study was performed to 150 Lung cancer patients patients 54 females and 96 males and matched with age and gender attending to Middle Euphrates Cancer Center in AL-Najaf province with group of 60 healthy individual as control. Blood sample was collected from all patients and control. IL-10 level were measured by enzyme-linked immunosorbent assay (ELISA). Single nucleotide polymorphism detected by ARMS-PCR technique. The result shown that IL-10-1082 G/A significantly (P<0.05) high frequencies of homozygous GG, and G allele carrier in lung cancer patients, in contrast homozygous AA and AG genotype and A allele appear at low frequency with patients. The data showed that genetic variants of the IL-10 affect the IL-10 production and associated with the progression of disease.
A EXPERIÊNCIA COM O CORPO MOTRIZ: criação e poética em dança contemporânea
Authors: Silva Kleber Rodrigo Lourenço 
Published: August 2022

Este artigo é a reelaboração de um capítulo da minha dissertação de mestrado, intitulada Da dança armorial ao corpo motriz: em busca do corpo brincante, apresentada em 2015 na Universidade Estadual Paulista (Unesp). Busco refletir sobre uma experiência de pesquisa em dança contemporânea: a criação do espetáculo Negro de estimação (2007), compartilhando aspectos do seu processo criativo que caracterizam a investigação por uma poética em dança, bem como relatos da trajetória da obra, que esteve em cartaz por treze anos. Esses apontamentos provocam reflexões sobre escrita em dança, performance e historicidade nas artes. O espetáculo aborda as linguagens do teatro e da dança, criando uma dramaturgia singular, que expõe as tensões vividas pelo sujeito negro em sociedade e os seus descentramentos. Nesse contexto de pesquisa, articularam-se também pensamentos sobre as matrizes e motrizes culturais nas artes negras performativas, dando origem à terminologia “corpo motriz” – método de investigação corporal no espetáculo. Quer-se, aqui, gerar reflexões sobre a linguagem em dança e seus modos de produção no panorama atual da cena brasileira.
PPP2R1A neurodevelopmental disorder is associated with congenital heart defects
Authors: Baker Elizabeth K. , Solivio Beulah , Pode‐Shakked Ben , Cross Laura Ann , Sullivan Bonnie , Raas‐Rothschild Annick , Chorin Odelia , Barel Ortal , Bar‐Yosef Omer , Husami Ammar , Hopkin Robert J. , Prada Carlos E. , Stottmann Rolf W. , Weaver Kathryn Nicole 
Published: August 2022

AbstractProtein phosphatase 2A (PP2A) is a heterotrimeric serine/threonine phosphatase that regulates numerous biological processes. PPP2R1A encodes the scaffolding “Aα” subunit of PP2A. To date, nearly 40 patients have been previously reported with 19 different pathogenic PPP2R1A variants, with phenotypes including intellectual disability, developmental delay, epilepsy, infant agenesis/dysgenesis of the corpus callosum, and dysmorphic features. Apart from a single case, severe congenital heart defects (CHD) have not been described. We report four new unrelated individuals with pathogenic heterozygous PPP2R1A variants and CHD and model the crystal structure of several variants to investigate mechanisms of phenotype disparity. Individuals 1 and 2 have a previously described variant (c.548G>A, p.R183Q) and similar phenotypes with severe ventriculomegaly, agenesis/dysgenesis of the corpus callosum, and severe CHD. Individual 3 also has a recurrent variant (c.544C>T, p.R182W) and presented with agenesis of corpus callosum, ventriculomegaly, mild pulmonic stenosis, and small patent foramen ovale. Individual 4 has a novel variant (c.536C>A, p.P179H), ventriculomegaly, and atrial septal defect. To conclude, we propose expansion of the phenotype of PPP2R1A neurodevelopmental disorder to include CHD. Further, the R183Q variant has now been described in three individuals, all with severe neurologic abnormalities, severe CHD, and early death suggesting that this variant may be particularly deleterious.
Pervaporative desalination of high salinity water using chitosan‐based thin film composite membranes
Authors: Li Zhelun , Baig Absar , Shahidi Kazem , Hudson Alexander , Roth Leah , Hatahet Mason , Wang Xuezhen 
Published: August 2022

AbstractPervaporation is regarded as one of the most promising technologies for desalination due to its extremely low energy consumption and ability to process high salinity solutions. As an easily accessible natural material with various advantages, chitosan is a promising material for pervaporative desalination. However, the research in this regard is scarce, and all existing works only focus on the desalination of NaCl solutions. Since chitosan has the potential to chelate with various ions, its desalination performance for different salt solutions might vary. In this study, we applied chitosan‐based membranes to pervaporative desalination for various salt solutions. The effects that feed salts, feed concentration, and temperatures had on their performance were comprehensively investigated. Moreover, two types of chitosan (Chitosan‐K and Chitosan‐D) were utilized to investigate the impact of chitosan types and confirm the universality of the conclusion. It was found that the feed salts significantly impact the desalination performance of chitosan membrane depending on their chelation level with chitosan polymers, and the cations (rather than anions) of the salts have a more significant effect. The salt rejection was almost complete at all tested conditions, demonstrating chitosan to be a promising material for pervaporative desalination.
Preparation and properties of modified graphene oxide / polyacrylamide composite nanoparticle gel system
Authors: Chen Yang , Li Xin , Zheng Shuang , Tian Yuqin , Zhu Rongjiao , Feng Xia , Liu Cunhui , Zhang Yichen 
Published: August 2022

AbstractGraphene oxide (GO) itself has a high viscous force on water and is very hydrophilic. To improve its hydrophobicity, adsorption performance, surface activity and stability, GO is needed to be modified for petroleum drive regulation applications. Therefore, GO was functionally modified with octadecylamine, and their structures were characterized by FT‐IR, X‐ray photoelectron spectroscopy (XPS), TGA, and SEM. Furthermore, the effective modification of long chain alkyl amine was verified. Then, the composite nanoparticle gel system was prepared by the interaction of modified graphene oxide (X‐GO) with polyacrylamide (HPAM) via chemical or physical forces. The optimal preparation conditions were determined by the response surface method (RSM). Under the optimal preparation conditions, the blocking rate can reach 95.27%. Turbiscan Lab stability omnipotent stability analysis and viscoelasticity testing showed that the composite gel system had good stability and viscoelasticity. The particle size result showed that the composite system was a nano system. In addition, the X‐GO/HPAM composite nanoparticle gel system also showed good temperature resistance, salt resistance, and shear resistance in performance tests. Finally, the result of the core‐blocking rate and breakthrough pressure test showed that it had good blocking performance, with a blocking rate of more than 95%.
Phenotype‐informed polygenic risk scores are associated with worse outcome in individuals at risk of Alzheimer's disease
Authors: Nordengen Kaja , Pålhaugen Lene , Bettella Francesco , Bahrami Shahram , Selnes Per , Jarholm Jonas , Athanasiu Lavinia , Shadrin Alexey , Andreassen Ole A. , Fladby Tormod 
Published: August 2022

AbstractIntroductionPatients with predementia Alzheimer's disease (AD) and at‐risk subjects are targets for promising disease‐modifying treatments, and improved polygenic risk scores (PRSs) could improve early‐stage case selection.MethodsPhenotype‐informed PRSs were developed by selecting AD‐associated variants conditional on relevant inflammatory or cardiovascular traits. The primary outcome was longitudinal changes in measures of AD pathology, namely development of pathological amyloid deposition, medial temporal lobe atrophy, and cognitive decline in a prospective cohort study including 394 adults without AD dementia.ResultsHigh‐risk groups defined by phenotype‐informed AD PRSs had significantly steeper volume decline in medial temporal cortices, and the high‐risk group defined by the cardiovascular‐informed AD PRS had significantly increased hazard ratio of pathological amyloid deposition, compared to low‐risk groups.DiscussionAD PRSs informed by inflammatory disorders or cardiovascular risk factors and diseases are associated with development of AD pathology markers and may improve identification of subjects at risk for progression of AD.