bluuebunny/crossref_metadata_2025_split huggingface dataset:
An Observational Study of Therapeutic Hypothermia and Factors Associated With Mortality in Late-Preterm and Term Neonates With Hypoxic-Ischemic Encephalopathy in a Middle-Income Country
Authors: Boo Nem Yun , Neoh Siew Hong , Chee Seok Chiong ,   for the Malaysian National Neonatal Registry
Published: June 2022

ObjectivesTo investigate the types of therapeutic hypothermia (TH) used and risk factors associated with mortality in late-preterm and term neonates (LPTN, gestation of ≥35 weeks) with hypoxic-ischemic encephalopathy (HIE) in a middle-income country.DesignThis was an observational retrospective cohort study.SettingA total of 44 neonatal intensive care units (NICUs) in the Malaysian National Neonatal Registry participated in the study.PatientsAll LPTN without major malformations and diagnosed to have HIE were included.Main Outcome MeasuresNumber of in-hospital mortality, and types of TH used [no TH, TH using commercially available servo-controlled devices (SCDs), passive TH by exposing neonates to NICU’s air-conditioned ambient temperature with/without the use of cooled gel packs (P±CGPs)].ResultsOf a total of 2,761 HIE neonates, 66.3% received TH. All NICUs provided TH; 55.4% NICUs had SCDs, which was administered to 43.6% (248/569) of severe, 51.6% (636/1,232) of moderate, and 18.6% (179/960) of mild HIE neonates. P±CGPs was used on 26.9% of severe, 33.4% of moderate, and 21.1% of mild HIE neonates. There were 338 deaths. Multiple logistic regression analysis showed that 5-min Apgar scores &lt;5 (aOR: 1.436; 95% CI: 1.019, 2.023), Cesarean section (aOR: 2.335; 95% CI: 1.700, 3.207), receiving no TH (aOR: 4.749; 95% CI: 3.201, 7.045), TH using P±CGPs (aOR: 1.553; 95% CI: 1.031, 2.338), NICUs admitted &lt;50 HIE cases (aOR: 1.898; 95% CI: 1.225, 2.940), NICUs admitted 50-&lt;100 HIE cases (aOR: 1.552; 95% CI: 1.065, 2.260), moderate HIE (aOR: 2.823; 95% CI: 1.495, 5.333), severe HIE (aOR: 34.925, 95% CI: 18.478, 66.012), Thompson scores of 7–13 (aOR: 1.776; 95% CI: 1.023,3.082), Thompson scores of ≥14 (aOR: 3.641; 95% CI: 2.000, 6.629), pneumothorax (aOR: 3.435; 95% CI: 1.996, 5.914), and foreigners (aOR: 1.646; 95% CI: 1.006, 2.692) were significant risk factors associated with mortality.ConclusionBoth SCD and P±CGP were used for TH. Moderate/severe HIE and receiving passive/no TH were among the risk factors associated with mortality.
Effects of 16 Weeks of Cheerleading on Physical Self-Esteem and Mental Health of Female College Students
Authors: Deng Chenliang , Yu Qiaoyan , Luo Ganglin , Lu Shuiping 
Published: June 2022

ObjectiveThis study aimed to analyze the influence of cheerleading on female college students’ physical self-esteem and mental health.Materials and MethodsIn total, 63 female college students from the University of Electronic Science and Technology of China were trained in cheerleading for 16 weeks. The scores of each sub-field of physical self-esteem and psychological symptoms were analyzed by using Physical Self-Perception Profile (PSPP) and Symptom Checklist 90 (SCL-90), respectively, at 0 and 16 weeks of the experiment.ResultsAfter 16 weeks of cheerleading exercise, female college students had significant differences in physical attractiveness (T = 4.18), physical quality (T = 4.39), and physical self-worth (T = 3.35) before and after the experiment (P &lt; 0.01). There were significant differences in physical condition (T = 3.87) and athletic ability (T = 2.88) before and after the experiment (P &lt; 0.05). Somatization (T = 6.485), obsessive-compulsive symptoms (T = 11.716), interpersonal sensitivity (T = 10.077), depression (T = 8.403), anxiety (T = 10.767), hostility (T = 10.866), terror (T = 9.260), paranoia (T = 10.414), psychosis (T = 9.610), sleep and eating disorders (T = 9.323), total symptom index (T = 13.245), and mean score of positive symptoms (T = 12.237) were significantly different (P &lt; 0.01).ConclusionCheerleading can significantly improve the level of female college students’ physical self-esteem, especially the self-esteem level of physical attractiveness, physical quality, and physical self-worth. They also experienced significant improvement in their psychological disorders, especially somatization, depression, and sleep and eating disorders, which effectively improved their overall mental health.
Sex Differences in Bipolar Disorders: Impact on Psychopathological Features and Treatment Response
Authors: Menculini Giulia , Steardo Luca , Sciarma Tiziana , D'Angelo Martina , Lanza Laura , Cinesi Gianmarco , Cirimbilli Federica , Moretti Patrizia , Verdolini Norma , De Fazio Pasquale , Tortorella Alfonso 
Published: June 2022

IntroductionSex differences were demonstrated in bipolar disorders (BD) concerning epidemiological, clinical, and psychopathological characteristics, but consensus is lacking. Moreover, data concerning the influence of sex on treatment response in BD is contrasting. The present cross-sectional study aimed to analyze sex differences in a population of BD subjects, with specific focus on psychopathological features and treatment response.Materials and MethodsSubjects diagnosed with BD according to the Diagnostic and Statistical Manual of Mental Disorders, 5th version (DSM-5) were recruited. Socio-demographic and clinical characteristics were collected. The Hamilton Rating Scale for Depression, the Mania Rating Scale (MRS), the brief version of the Temperament Evaluation of Memphis, Pisa and San Diego—Münster version (briefTEMPS-M), and the Barratt Impulsiveness Scale−11 items (BIS-11) were used for psychopathological assessment. Treatment response was appraised with the Alda Scale. We performed bivariate analyses to compare socio-demographic, clinical, and psychopathological characteristics between men and women (p &lt; 0.05). A logistic regression was run to analyze features that were significantly associated with female sex.ResultsAmong the recruited 219 BD subjects, 119 (54.3%) were females. Women had a lower scholarity (p = 0.015) and were less frequently employed (p = 0.001). As for psychopathological features, a higher MRS total score (p &lt; 0.001) was detected among women, as well as higher BIS-11 total score (p = 0.040), and briefTEMPS-M score for anxious temperament (p = 0.006). Men showed higher prevalence of DSM-5 mixed features (p = 0.025), particularly during a depressive episode (p = 0.014). Women reported longer duration of untreated illness (DUI) (p &lt; 0.001). There were no sex differences in the Alda Scale total score when considering the whole sample, but this was significantly higher among men (p = 0.030) when evaluating subjects treated with anticonvulsants. At the logistic regression, female sex was positively associated with longer DUI (p &lt; 0.001; OR 1.106, 95% CI 1.050–1.165) and higher MRS total score (p &lt; 0.001; OR 1.085, 95% CI 1.044–1.128) and negatively associated with employment (p = 0.003; OR 0.359, 95% CI 0.185–0.698) and DSM-5 mixed features (p = 0.006; OR 0.391, 95% CI 0.200–0.762).ConclusionsThe clinical presentation of BD may differ depending on sex. The severity of BD should not be neglected among women, who may also display worse treatment response to anticonvulsants.
Comparison of Image Quality and Radiation Dose Between Single-Energy and Dual-Energy Images for the Brain With Stereotactic Frames on Dual-Energy Cerebral CT
Authors: Zhao Xiaojing , Chao Wang , Shan Yi , Li Jingkai , Zhao Cheng , Zhang Miao , Lu Jie 
Published: June 2022

BackgroundPreoperative stereotactic planning of deep brain stimulation (DBS) using computed tomography (CT) imaging in patients with Parkinson's disease (PD) is of clinical interest. However, frame-induced metal artifacts are common in clinical practice, which can be challenging for neurosurgeons to visualize brain structures.ObjectivesTo evaluate the image quality and radiation exposure of patients with stereotactic frame brain CT acquired using a dual-source CT (DSCT) system in single- and dual-energy modes.Materials and MethodsWe included 60 consecutive patients with Parkinson's disease (PD) and randomized them into two groups. CT images of the brain were performed using DSCT (Group A, an 80/Sn150 kVp dual-energy mode; Group B, a 120 kVp single-energy mode). One set of single-energy images (120 kVp) and 10 sets of virtual monochromatic images (50–140 keV) were obtained. Subjective image analysis of overall image quality was performed using a five-point Likert scale. For objective image quality evaluation, CT values, image noise, signal-to-noise ratio (SNR), and contrast-to-noise (CNR) were calculated. The radiation dose was recorded for each patient.ResultsThe mean effective radiation dose was reduced in the dual-energy mode (1.73 mSv ± 0.45 mSv) compared to the single-energy mode (3.16 mSv ± 0.64 mSv) (p &lt; 0.001). Image noise was reduced by 46–52% for 120–140 keV VMI compared to 120 kVp images (both p &lt; 0.01). CT values were higher at 100–140 keV than at 120 kVp images. At 120–140 keV, CT values of brain tissue showed significant differences at the level of the most severe metal artifacts (all p &lt; 0.05). SNR was also higher in the dual-energy mode 90–140 keV compared to 120 kVp images, showing a significant difference between the two groups at 120–140 keV (all p &lt; 0.01). The CNR was significantly better in Group A for 60–140 keV VMI compared to Group B (both p &lt; 0.001). The highest subjective image scores were found in the 120 keV images, while 110–140 keV images had significantly higher scores than 120 kVp images (all p &lt; 0.05).ConclusionDSCT images using dual-energy modes provide better objective and subjective image quality for patients with PD at lower radiation doses compared to single-energy modes and facilitate brain tissue visualization with stereotactic frame DBS procedures.
Comparative Analysis of Elderly Patients Undergoing Radical Cystectomy With Ureterocutaneostomy or Ileal Conduit With a Special Focus on Bowl Complications Requiring Surgical Revision
Authors: Mally David , John Patricia , Pfister David , Heidenreich Axel , Albers Peter , Niegisch Günter 
Published: June 2022

ObjectivesIleal conduits (ICs) carry an additional perioperative complication risk due to the bowel procedure. This analysis compares surgical outcomes in patients ≥75 years of age with ureterocutaneostomy (UCN) and IC after cystectomy (Cx).MethodsData of 527 patients included in a retrospective cystectomy database of two high volume centers (2008–2020) were queried to identify elderly patients (≥75 years) who underwent Cx either with IC or UCN. Patient characteristics of all patients [age, BMI, Charlson Comorbidity Index (CCI)], perioperative parameters (operation time, blood loss, transfusions, tumor stage), and postoperative complications (clavien &gt;IIIA, intensive care unit (ICU) stay) were compared. As special focus, bowel complications requiring surgical revision (rBCs) were analyzed. In patients with IC, the rate of ureteral implantation stenosis (USt) was recorded. As a population of special interest, patients ≥80 years of age were analyzed separately. Categorical data were compared using Fisher exact test, and continuous data were compared using Mann–Whitney U test.ResultsA total of 163 patients ≥75 years of age (125 IC, 38 UCN) were identified. Patients with UCN were older and presented with a higher CCI, though differences were not statistically different. Surgery with palliative intent was more frequent in patients with UCN (37 vs. 10%). Operation time in UCN was significantly shorter (233 vs. 305 min, p = 0.02), while blood loss and transfusion rate were comparable. Overall complication rate (Clavien-Dindo grade IIIA–IVB) was comparable (UCN 34% vs. IC 37%). However, rBC was a rare complication in UCN (3/38) as compared to patients with IC (15/125). Frequency of postoperative ICU stay (UCN 16% vs. IC 16%) and 90-day mortality did not differ (UCN 3/38 patients, IC 5/125 patients). Regarding long-term follow-up, USt requiring revision or permanent stenting was seen in 18/125 (14%) patients with IC. In patients &gt;80 years of age, results were comparable to the main cohort. Low event rate regarding complications and bias inherent of a retrospective analysis (selection bias, unequal distribution in case numbers) precludes detection of statistical differences regarding patients' characteristics and overall complication rate.ConclusionUCN is an alternative to IC in elderly and/or frail patients. Severe bowel complications are numerically less frequent and operation time is minimized.
ISOLASI DAN IDENTIFIKASI Streptomyces sp. PADA KOLAM TANAH DI DESA TENGGUR TULUNGAGUNG JAWA TIMUR
Authors: Prasetya Didik 
Published: June 2022

Tenggur Village, Rejotangan District, Tulungagung Regency is a village where the majority of its residents work as fish farmers. Currently, one of the diseases that attack fish is thought to be caused by infection with Aeromonas hydrophila bacteria, the fish's body parts will bleed, especially the chest, abdomen and at the base of the fins, and the fish will die even though the pond is well maintained. Fish disease control is currently still using chemicals so that the impact of beneficial bacteria will be destroyed in the pond environment and residues of compounds in fish that will be harmful to health if consumed. Streptomyces bacteria are bacteria that are able to produce enzymes and antibiotics that can be used as biocontrol agents for several diseases caused by bacteria. The purpose of this study was to isolate and identify Streptomyces bacteria from soil ponds in Tenggur Tulungagung Village, East Java. Isolation was carried out using the serial dilution method. Streptomyces were isolated from an earthen pond with a depth of 15 cm from the soil surface and planted on Yeast Extract Malt Agar (ISP4) media. The growing colonies were observed macroscopically and microscopically, as well as biochemical tests using the Guide to the Classification and Identification of the Actinomycetes and Their antibiotics from Lechevalier and Waksman (1973). The results showed 4 isolates of Streptomyces sp.1, Streptomyces sp.2, Streptomyces sp.3, Streptomyces sp.4. The four isolates will later be tested against Aeromonas hydrophyla bacteria, which is the cause of Motile Aeromonas septicemia.
ANALISIS KUALITAS FISIK DAN BAKTERIOLOGI AIR BERSIH PERUSAHAAN DAERAH AIR MINUM DESA SELANBAWAK TABANAN
Authors: Jirna I Nyoman 
Published: June 2022

ABSTRACTIntroduction: PDAM water Selanbawak village is water used by people at Selanbawak Village for their daily needs such as drinking water. Drinking water qualify the requirements of physics, microbiology, chemistry and radioactivity (Permenkes 492 of 2010). In 2020 there occur a landslide disaster which cause damage to pipes, causing health problems such as diarrhea. Methods: The research used quantitative with a descriptive design using the simple random sampling technique of 179 populationsThe study was conducted to determine the quality of clean water from PDAM based on physical and bacteriological parameters from January to April 2021 at the homes of the residents of Banjar Selanbawak kaja, then physical and bacteriological examinations using the Most Probable Number (MPN) method were carried out at Panureksa Utama Laboratory. Results: The results of physical quality from 15 samples (100%) qualify the health requirements based on Permenkes RI No. 492 / MENKES / PER / IV / 2010. Meanwhile, examination of Coliform bacteria (67%) with the category fulfilling the health requirements and examination of Escherichia coli bacteria (73%) with the category fulfilling the requirements based on Permenkes RI No. 492 / MENKES / PER / IV / 2010. Conclusion: Based on these results, it can be concluded that most of the PDAM water still qualify health requirements.Keywords: Selanbawak, physical, bacteriology, PDAM water
PERBANDINGAN IDENTIFIKASI Toxoplasma gondii MENGGUNAKAN METODE POLYMERASE CHAIN REACTION (PCR) DAN METODE ENZYME LINKED FLUORESCENT ASSAY (ELFA)
Authors: Mushlih Miftahul , Nurfitriana Alifia , Ningsih Kurnia Wahyu , Azizah Nurul , Arian Nia Lukita 
Published: June 2022

Toxoplasmosis is an infectious disease that does not show specific symptoms. This study aimed to determine the differences results of T. gondii detection in human blood using the PCR (polymerase chain reaction) with the ELFA (Enzym Linked Fluorescent Assay) method. The research was done by descriptive exploratory methods. Samples taken from 9 West Sumatra Pramita Clinics Laboratory and 1 person came from Sidoarjo as a control. Data analyzes was conducted by a chi-square test with a 95% confidence level. In the ELFA method detects IgG Anti-Toxoplasma. Whereas the molecular test detects B1 gene target. The serological test was able to detect 9 patients of toxoplasmosis and 1 patient was negative/ control. The molecular test showed a specific band with 195 bp in length. The accuracy of the molecular test was 77% (T count (4.4) T table (3.84). Based on the results its can be concluded that there a difference in identification between the PCR method and the ELFA method.
Indicators of nonspecific resistance of the organism in patients with destructive forms of erysipelas
Authors: Vasylevskaya L. A. 
Published: June 2022

Purpose of the study. to evaluate the indicators of nonspecific resistance of the organism in patients with destructive forms of erysipelas.
Materials and methods. 114 case histories of patients who were hospitalized in the center of purulent - septic surgery of KNP "City Hospital G3" in Zaporozhye for the period 2019-2020 were analyzed.
According to the forms of the disease, patients were distributed as follows: erythematous - 24 (21.0%) - control group; bullous - 28 (24.6%), phlegmonous form - 48 (42.1%), necrotic - 14 (12.3%). Among the latter, 10 patients were aggravated by sepsis. 6 patients died, mortality was 60%.
Results. Complementary activity of blood serum in patients with destructive forms of erysipelas in a favorable course of the disease is significantly increased, which is not observed in patients with sepsis. A significant increase in the HCT- test provides information on the degree of functional irritation of peripheral blood neutrophils under the influence of pathogens. But its increase almost 2 times until the moment of clinical recovery indicates the ongoing stimulation of phagocytic cells of peripheral blood, which caused changes in the metabolic profile of cast iron. The decrease in phagocytic activity in patients with sepsis may be due to a defect in the absorption capacity of polymorphonuclear leukocytes, and its progressive decrease, to some extent, may be a marker of adverse disease outcome.
Conclusion. The degree of changes in the indicators of nonspecific resistance of the organism makes it possible to assess the reserves of the immune response, to determine the intensity and dynamics of destructive forms of erysipelas.
IS CANCER SCREENING DURING WAR?
Authors: Kovalov O. O. 
Published: June 2022

The problem of cancer during the war and after the end of hostilities in Ukraine will worsen. According to some estimates, cancer incidence and mortality in our country may exceed the pre-war level.
Along with exposure to carcinogens, important factors that influence the development of cancer in people after the war are the massive demographic movements of the population, which increase the risk of transmission of oncogenic bacteria and viruses, such as Helicobacter pylori, Epstein-Barr virus, hepatitis B and C viruses and human papilloma virus. Sexually transmitted infections, including as a result of violence against civilians, occupy a special place in this series.
Today in Ukraine there is not only an urgent need for oncological screening, but all the possibilities for this. Self-sampling technology for cervical cancer screening is indispensable and has no alternative. They allow for mass surveys of the population, refugees and displaced persons affected by hostilities, without diverting health care resources for this.
The Qvintip test from the Swedish company Aprovix can be used not only to detect oncogenic human papillomavirus DNA strains, but also for PCR diagnosis of most sexually transmitted infections - bacterial vaginosis, candidiasis, gonorrhea, chlamydia, detection of trichomonas, ureaplasma, mycoplasma, treponema.
Screening in Ukraine is financed by the non-governmental non-profit organization of the charitable Foundation "World Against Cancer", created in the first days of the war.
Effectiveness of Treatment of Chronic Pelvic Pain Caused by Disharmonal Uterine Pathology in Women of Fertile Age
Authors: Можейко Л.Ф. , Маркова Е.Д. 
Published: June 2022

Хроническая тазовая боль – одна из серьезнейших проблем женского здоровья, свидетельствующая о наличии заболеваний, неблагоприятным образом отражающихся на репродуктивном здоровье и качестве жизни. Среди причин обращения к гинекологу 10% занимает хроническая тазовая боль, обусловленная дисгормональной патологией матки.В статье приведен анализ патофизиологических и патоморфологических основ развития тазовой боли, а также особенностей восприятия боли у женщин с дисгормональной патологией матки.Характер, морфология и механизмы возникновения боли различаются в зависимости от патологии: при лейомиоме характер болей зависит от расположения миоматозного узла, плотности распределения нервных волокон в псевдокапсуле миомы и прилегающем миометрии. Причины возникновения боли также связывают с механическим сдавлением нервных сплетений, перерастяжением брюшины и ишемией узла.Показана эффективность лекарственного средства природного происхождения миомин в терапии доброкачественной опухоли матки, сочетанной с неатипической гиперплазией эндометрия, клинически проявляющейся развитием симптома хронической тазовой боли. Установлены положительная динамика снижения проявлений симптомов патологии, удобство и безопасность применения лекарственных средств, а также регрессивные изменения в процессе лечения. Установлена целесообразность использования предложенных схем терапии.
Chronic pelvic pain is one of the most serious women’s health problems, indicating the presence of diseases that adversely affect reproductive health and quality of life. Among the reasons for visiting a gynecologist, 10% is occupied by chronic pelvic pain caused by disharmonious pathology of the uterus.The article provides an analysis of the pathophysiological and pathomorphological foundations of the development of pelvic pain, as well as the characteristics of pain perception in women with disharmonic pathology of the uterus.The nature, morphology and mechanisms of pain differ depending on the pathology: in leiomyoma, the nature of pain depends on the location of the myomatous node, the distribution density of nerve fibers in the pseudocapsule of the fibroids and the adjacent myometrium. The causes of pain are also associated with mechanical compression of the nerve plexuses, hyperextension of the peritoneum and node ischemia.The effectiveness of the natural drug myomine in the treatment of benign uterine tumors combined with non-atypical endometrial hyperplasia, which is clinically manifested by the development of a symptom of chronic pelvic pain, has been shown. A positive trend in reducing the manifestations of symptoms of pathology, the convenience and safety of the use of drugs, as well as regressive changes in the treatment process were established. The expediency of using the proposed therapy regimens has been established.