bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prediction of Multi-Epitopic Domains of a Putative Oral Vaccine against Hepatitis C Virus
Authors: Adeoti Olatunde Micheal 
Published: June 2022

For vaccine development, triggering an immune response is desired. Designing and assessing vaccine candidates for the appropriate immune response is critical for their success. Hepatitis C virus is the major cause of liver disease. Anti HCV vaccines if designed is rational decision to reinforce specific T-cell as a crucial aspect of effective antiviral treatment. This study explored the use of bioinformatics tools by retrieval of twenty (20) HCV proteins which were selected for vaccine design. These were retrieved from UniProt server based on their antigenicity, virulence, subcellular localization, essentiality non-homology and other physical parameters, including, TM helices, and relative molecular mass. BLASTp revealed 80% non-identity with Homo sapiens genes. The Epitopes obtained include: Q3S781_9HEPC52-71, POLG_HCVBK442-461, POLG_HCVJA2-21, POLG_HCVJ177-95, POLG_HCVCO445-464, POLG_HCVR61107-1126, POLG_HCVJP47-66, POLG_HCVTW664-683, POLG_HCVTR446-465, LTOR5_HUMAN23-42, POLG_HCVT5100-119, POLG_HCVJT77-96, HOIL1_HUMAN169-188, POLG_HCVJ4644-663, POLG_HCVJ847-66, TFB2M_HUMAN49-68, RSF1_HUMAN138-157, A8DGK3_9HEPC77-96, A8DHN1_9HEPC54-73, and A8DFL0_9HEPC2-21. An antigenicity score of 0.6004 was obtained with the use of VaxiJen server. The allergenicity prediction showed that the vaccine is not allergenic with the use of AllerTOP v.2.0 and AlgPred servers. The molecular weights and theoretical pI of protein were 45.1 kDa and 10.24 kDa respectively. A potentially suitable vaccine candidate with multivariant regions and immunogenic which could be antagonistic to HCV was designed.
Effectiveness of the Automated Writing Evaluation Program on Improving Undergraduates’ Writing Performance
Authors: Geng Jingxin , Razali Abu Bakar 
Published: June 2022

Automated Writing Evaluation program (AWE) has gained increasing ground in ESL/EFL writing instruction because of its instructional features, such as the instant automated writing score system and the diagnostic corrective feedback in real-time for individual written drafts. However, there is little known about how the automated feedback provided by the AWE program can impact students&rsquo; writing performance in an authentic classroom and how to make the most of it to improve students&rsquo; writing performance effectively, especially for ESL/EFL undergraduate students. This paper attempts to offer an overview of the investigation of the effectiveness of automated feedback via a literature review. According to the inclusion and exclusion criteria, eleven articles published in the past five years were finally included for the analytical synthesis. The literature review matrix for the synthesis reveals the research gaps of the previous literature in the levels of the effectiveness of the automated feedback, including the lack of the design of delayed post-test, writing performance in terms of writing traits, and students&rsquo; writing strategies regarding the use of AWE program. The conclusion highlights the need for future research by bridging the gaps of exploring the long-term internalized impact of the embedded use of automated feedback and an advanced teaching method on improving both students&rsquo; overall writing performance and analytic writing scores.
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Peningkatan Kemampuan Pemecahan Masalah Matematika Siswa SMP Kecamatan Palipi Menggunakan Pembelajaran Berbasis Masalah
Authors: Sutan Mara Doli S  , Ester  , Ronny S  , Anita Yus  , Aman Simaremare  
Published: June 2022

Kecakapan hidup merupakan kompetensi yang harus dimiliki individu dalam melanjutkan aktivitas hidup sehari-hari. Konstruksi pengetahuan, keterampilan dan sikap berbasis masalah membekali siswa untuk memeliki kecakapan yang baik. Penelitian ini untuk bertujuan meningkatkan kemampuan siswa untuk memecahkan masalah matematika menggunakan pembelajaran berbasis masalah (PBM). Pendekatan yang digunakan penelitian Tindakan kelas. Subjek adalah siswa kelas VIII SMP Kecamatan Palipi yang berjumlah 35 siswa. Hasil 1) penerapan pendekatan pembelajaran berbasis masalah dapat meningkatkan kemampauan pemecahan masalah siswa pada pokok bahasan sistem persamaan linear dua variabel di kelas VIII SMP Kecamatan Palipi setelah melewati siklus I dan II. Pada siklus I telah diperoleh secara klasikal terdapat 28 siswa atau 80% dari jumlah siswa yang mengikuti tes telah memiliki tingkat kemampuan konsep berada dalam kategori minimal cukup. Pada siklus II terdapat 33 siswa atau 94,29% dari jumlah siswa yang mengikuti tes telah memiliki tingkat kemampuan konsep berada dalam kategori minimal cukup. 2) penerapan pendekatan pembelajaran berbasis masalah dapat meningkatkan kadar aktivitas aktif siswa dalam proses belajar mengajar pada pokok bahasan sistem persamaan linear dua variabel di kelas VIII SMP Kecamatan Palipi setelah melewati siklus I dan II.
PERLINDUNGAN HUKUM TERHADAP TENAGA KESEHATAN PANDEMI COVID 19 BERDASARKAN UNDANG-UNDANG NOMOR 36 TAHUN 2009 TENTANG KESEHATAN
Authors: Anita Theresia  , Adi Wijaya  , Muhamad Japri  
Published: June 2022

Pandemic Covid 19 yang hingga saat ini masih kita alami tidak hanya memberi dampak bagi seluruh umat manusia, tetapi tenaga kesehatan sebagai garda terdepan harus bersiap dengan segala resiko yang mungkin terjadi saat menjalankan tugasnya. Sebagai garda terdepan yang setiap hari merawat pasien Covid-19 dengan resiko sangat tinggi terhadap penularan virus tersebut. Perlindungan hukum bagi para tenaga kesehatan sering terabaikan, seolah mayarakat apatis dan beropini bahwa itu sudah sebagai tugas dan tanggungjawab sebagai tenaga medis. Resiko penularan virus yang tidak hanya bisa dialami oleh tenaga kesehatan itu sendiri tetapi juga anggota keluarganya. Penulis menggunakan metode library research atau kajian pustaka. Riset kajian kepustakaan ini adalah melakukan penelitian dari buku-buku perpustakaan, majalah, jurnal dan artikel dan sumber dari internet yang relevan dengan masalah yang dibahas. Berikut kajian berdasarkan Undang-Undang Nomor 36 Tahun 2009 Tentang Kesehatan.
SOSIALISASI DAN PELATIHAN PENYUSUNAN ANGGARAN DASAR RUMAH TANGGA YANG PRODUKTIF BAGI IBU-IBU PKK DI RW 08 KELURAHAN SERPONG
Authors: Isep Amas Priatna  , Gojali Supiandi  , Udin Saprudin  , Eman Suleman  , Neneng Tita Amalya  
Published: June 2022

Pada PKM ini dengan mengambil objek pengabdian yaitu ibu-ibu yang tergabung dalam PKK RW 09 Kelurahan Serpong Kecamatan Serpong Tangerang Selatan. Mitra pengabdian pada PKM ini Pengurus RW 08. Masalah yang diambil berasal dari Tim Penggerak Pemberdayaan dan Kesejahteraan Keluarga (PKK) di RW 08 Kelurahan Serpong mencari model dalam upaya mencapai sasaran yang optimal serta mencoba merancang pelaksanaan berbagai kegiatan. Sehingga kegiatan PKK dapat terlaksana di setiap Kelurahan, terutama di Lingkup RW 08 Kelurahan Serpong Tangerang Selatan. Sebelum menentukan metode yang tepat maka tim mengumpulkan informasi dari hasil survey yang kami lakukan melalui wawancara dan observasi selanjutnya kami langsung membuat Tim Kelompok guna merancang program kegiatan yang cocok dengan kondisi obyek. Dalam pelaksanaan PKM ini kami mengadakan sosialisasi sekaligus pelatihan penyusunan anggaran dasar rumah tangga PKK yang produkstif dengan tujuan meningkatkan motivasi perorangan, kelompok/instansi/lembaga agar berperan serta secara aktif dalam upaya menyukseskan Gerakan PKK. Kedepan, pengurus RW sebagai mitra pengabdian disarankan agar memiliki jadwal secara rutin untuk mengadakan pelatihan yang menunjang pada kegiatan yang lebih produktif agar PKK semakin berkembang dan maju.
Child Custody after Divorce (Case Study of Court Decision Number 242/Pdt.G/2019/PN.Tjk)
Authors: Amalia Damayanti  , Mohammad Fajri Mekka Putra  
Published: June 2022

Marriage is the legally or formally recognized union of two people, a man and a woman, as partners who are physically and mentally bonded with the aim of forming a harmonious family or household. However, not all marriages last forever. When a marriage ends, divorce can occur. Divorce itself brings legal consequences, one of which is regarding child custody. Child custody after the occurrence of a divorce based on the provisions of Article 41 letter (a) of Law Number 1 of 1974 stipulates that both parents are obliged to continue to care for and educate their child for the benefit of the child and if there is a dispute regarding the control of the child, the court gives its decision. However, in reality a lot has happened in nurturing and educating child after the divorce, as in the case of Number 242/Pdt.G/2019/PN.Tjk.
Corticosteroid, Platelet-Rich Plasma, and Ozone Injections for Sinus Tarsi Syndrome
Authors: Toy Serdar , Tuncer Kutsi , Topal Murat , Aydın Ali 
Published: June 2022

Background: Sinus tarsi syndrome is characterized by permanent pain on the anterolateral side of the ankle due to chronic inflammation characterized by fibrotic tissue remnants and synovitis accumulation after repeated traumatic injuries. Few studies have documented the outcome of injection treatments for sinus tarsi syndrome. We sought to determine the effects of corticosteroid and local anesthetic (CLA), platelet-rich plasma (PRP), and ozone injections on sinus tarsi syndrome.
Methods: Sixty patients with sinus tarsi syndrome were randomly divided into three treatment groups: CLA, PRP, and ozone injections. Outcome measures were visual analog scale, American Orthopedic Foot and Ankle Society Ankle-Hindfoot Scale (AOFAS), Foot Function Index, and Foot and Ankle Outcome Score before injection compared with 1, 3, and 6 months after injection.
Results: At the end of months 1, 3, and 6 after injection, significant improvements were observed in all three groups compared with baseline (P < .001 for all). At months 1 and 3, improvements in AOFAS scores were similar in the CLA and ozone groups; those in the PRP group were lower (P = .001 and P = .004, respectively). At month 1, improvements in Foot and Ankle Outcome Score were similar in the PRP and ozone groups and higher in the CLA group (P < .001). At 6-month follow-up, there were no significant differences in visual analog scale and Foot Function Index results among the groups (P > .05).
Conclusions: Ozone, CLA, or PRP injections could provide clinically significant functional improvement for at least 6 months in patients with sinus tarsi syndrome.
Assessing the size at maturity, spawning, and condition of the truncate soft-shell clam (Mya truncata) of southern Baffin Island, Nunavut, Canada
Authors: Wood Jessica M. , Donovan Meghan , Grant Scott M. 
Published: June 2022

The truncate soft-shell clam Mya truncata is an important source of country food for Inuit communities across the territory of Nunavut, Canada. M. truncata also plays an important role in marine ecosystems, yet there is little understanding of their life history and condition in Canadian Arctic waters. To provide a foundation on which aspects of the life history and condition of M. truncata of Baffin Island can be monitored in the future with a changing climate and fishery development, this study estimated size at maturity and provides insights into the spawning cycle and weight-length condition indices of clams from inner Frobisher Bay and the north shore of the Hudson Strait. Male and female M. truncata exhibited similar lengths at 50% attainment of sexual maturity, 31 mm and 32 mm shell length (SL), respectively. Most (77%) of the sexually mature M. truncata collected from inner Frobisher Bay in late August and 35% of clams collected from the Hudson Strait in early September were in the ripe stage of gonadal development. These results lead us to suggest a spring spawning season and that M. truncata invest in gonadal development for the next year’s spawning during the late summer-early autumn ice-free season while phytoplankton concentrations are high. Dry bodyweight-SL relationships were used to show that M. truncata condition can differ significantly over small and large spatial scales based on plotted 95% confidence intervals.
Update in the Relationship between Gut Microbiota and Kawasaki Disease
Authors: Jiao Fuyong , Ding Xiaojin , Feng Jianying , Wang Juyan , Zhang Ling 
Published: June 2022

Kawasaki disease (KD) is an acute febrile systemic necrotizing medium and small vasculitis in children, mainly affecting children under 5 years old, and has become the main cause of pediatric acquired heart disease in developing countries. The exact etiology of this disease is still unclear. At present, researcheson KD are mostly limited to susceptibility gene, infection and immunity. How ever, there are few studies on the correlation between intestinal flora and KD. In recent years, some studies have found that KD is related to the imbalance of intestinal flora, and the abundance and structure of intestinal flora in children with KD change, which contributes to the occurrence and development of KD by affecting the release of inflammatory factors, damaging the intestinal barrier function and activating the autoimmune system. This review aims to elucidate the relationship between gut microflora and KD, and the mechanism of action and that of probiotics
Prevalence of Maternal Complications after Caesarean Section in Women with Abnormal BODY MASS INDEX (BMI)
Authors: Karamat Shahida , Mubarik Sana , Khokhar Naeem Akhtar , Resham . , Jabbar Asifa Abdul , Khatoon Nusrat 
Published: June 2022

Objective: To determine the frequency and maternal complications of cesarean section in women with BMI >25 kg/m2.
Methodology: This descriptive Case series was done at the Gynaecology and Obstetric Unit III, Civil Hospital Karachi for 6 months i.e. May - Nov 2013. Total 164 obese pregnant women who presentedat gestational age >37 weeks, singleton pregnancy with cephalic presentation were included. Data consists of information on demographic items, gestational age, and parity. BMI was calculated by taking weight in kg divided by height in m2. Patients were monitored for progress of labour and mode of delivery was recorded. Maternal complications were identified and noted in pre design proforma.
Results: Frequency of maternal complications in women with BMI >25 kg/m2 was found in 57.14%women.Induced labour was the commonest i.e. 35.1% women followed by primary post-partum hemorrhage (PPH) 13% and shoulder dystocia was observed in 9.1%.
Conclusion: The burden of overweight and obesity in pregnant females belong to local population is high. So it is concluded that pre pregnancy normal body weight females with high BMI during pregnancy require special follow-ups and counselling sessions during pregnancy and delivery.
Frequency of Cardiomyopathy in Children having Thalassemia Major: A Cross-Sectional Study
Authors: Jamali Abdul Rauf , Mujeeb-u-Rehman . , Chand Ram , Jokhio Dilawar Khan , Kubar Naseem Ahmed , Memon Naseer Ahmed , Chohan Muhammad Nadeem 
Published: June 2022

Aim: To determine the frequency of cardiomyopathy in children having Thalassemia major diagnosed on the basis of Echocardiography.
Study Design: A cross-sectional study.
Place and Duration: Paediatric department at Peoples medical college hospital (PMCH), Nawabshah from September 2019 to March 2020.
Methodology: A total of 236 Thalessemic children visiting as outpatients or inpatients meeting inclusion criteria were enrolled. Informed consent was taken from the patients or their attendants. All demographic variables that included age, gender, address, educational status, family history, age of diagnosis of the disease, start of treatment and number of transfusions graded as none, occasional, were included. Echocardiography findings were performed and then recorded.
Results: Mean age of the patients was 10.60±4.064 (5-18) years, 110(49.1%) study subjects were female and 126(50.8%) were male patients. While 75(31.78%) study subjects have family history of thalassemia. A total of 87(36.9%) study subjects have left ventricular dysfunction, 13(14.9%) have global dysfunction, 11(12.6%) have isolated systolic dysfunction and 63(72.4%) have isolated diastolic dysfunction.
Conclusion: In -thalassemia, heart disease is the key determinant of prognosis and survival. In this study we found a significant number of thalassemia children having cardiac involvement and ventricular dysfunction.
An Improbable Amino‐Functionalized Fullerene Spacer Enables 2D/3D Hybrid Perovskite with Enhanced Electron Transport in Solar Cells
Authors: Zhou Weiran , Jia Lingbo , Chen Muqing , Li Xingcheng , Su Zhenhuang , Shang Yanbo , Jiang Xiaofen , Gao Xingyu , Chen Tao , Wang Mingtai , Zhu Zonglong , Lu Yalin , Yang Shangfeng 
Published: June 2022

Abstract2D perovskites possess superior humidity stability but inferior power conversion efficiency (PCE) compared with 3D perovskites due to their typically insulating spacers. Size of the spacer cation is determinative for the formation of 2D perovskite, and fullerene is believed not to be capable of templating 2D perovskite structure because of its larger size than the width of the lead‐halide octahedron despite its well‐known strong electron‐accepting ability. Herein, a novel amino‐functionalized fullerene derivative (abbreviated as C60‐BPAM) is developed and an ‘improbable’ spacer for 2D/3D hybrid perovskite solar cells (PSCs), achieving enhanced electron transport is applied. Unlike most of the reported alkylammonium spacers that are based on insulating organic tails, the incorporation of a highly conductive fullerene tail within C60‐BPAM2+ leads to increased electron density in 2D/3D perovskite and induces an additional built‐in electric field, facilitating electron transport in PSCs. Besides, the 2D/3D hybrid structure helps to passivate both of the shallow‐ and deep‐level defects within perovskite. As a result, the PCE of 2D/3D PSCs improves from 19.36% (3D MAPbI3 PSCs) to 20.21%. Moreover, the 2D/3D PSCs show significant improvement in the humidity stability compared to the 3D counterparts.
All‐Direct‐Ink‐Writing of Artistic Supercapacitors: Toward On‐Demand Embodied Power Sources
Authors: Lee Seong‐Sun , Kim Se‐Hee , Ahn David B. , Lee Kwon‐Hyung , Jo Yejin , Jeong Sunho , Lee Sang‐Young 
Published: June 2022

AbstractDespite the extensive studies on printed power sources for user‐customized shape‐versatile electronics, most of them have still focused on printing of electrochemically active materials, with little attention to passive components such as current collectors and packaging, thus hindering their versatile application. Here, all‐direct‐ink‐writing (DIW) of artistic supercapacitors (ASCs) as a facile and scalable strategy to enable power source‐unitized monolithic electronic devices with various form factors is demonstrated. Interdigitated nickel current collectors embedded inside a polyurethane support layer are fabricated using DIW printing, which can facilitate the subsequent printing of multi‐scale, ultrathick electrodes. Interstitial voids between the DIW‐printed adjacent electrode layers are densely infiltrated by click‐crosslinkable electrolyte inks with well‐tuned rheological properties. The void‐free electrode/electrolyte assembly is conformally printed with a waterproof packaging ink to enable hermetic encapsulation, eventually producing all‐DIW‐printed ASCs with efficient space utilization, design diversity, and dimensional scalability. Notably, the resulting ASC can be seamlessly unitized with arbitrary‐shaped 3D objects (e.g., miniature pagodas), allowing for the potential development of on‐demand embodied power sources for electronic devices.
Soft and Tough Microcapsules with Double‐Network Hydrogel Shells
Authors: Lee Sangmin , Hamonangan Wahyu Martumpal , Kim Jong Hyun , Kim Shin‐Hyun 
Published: June 2022

AbstractHydrogel‐shelled microcapsules allow communication with the surrounding through molecule‐selective exchanges, serving as microcarriers for cells, drugs, catalysts, and nanoparticle sensors. However, the low mechanical stability of hydrogels has restricted their use in strong shear flows or compressive fields. Here, microcapsules are designed composed of water core and double‐network (DN) hydrogel shell using water‐in‐oil‐in‐water‐in‐oil triple‐emulsion templates to secure high mechanical stability as well as molecular size‐selective permeation. Monodisperse triple‐emulsion droplets are prepared using microfluidic devices. The core water contains divalent ions and the outer water layer contains poly(ethylene glycol)diacrylate (PEGDA) and sodium alginate. The PEGDA is first photocrosslinked by ultraviolet irradiation and the alginate is second ionically crosslinked with an infusion of divalent ions from the core by rupturing the middle oil layer. The resulting DN shells show excellent mechanical stability in comparison with single‐network (SN) shells made of PEGDA only. Enhanced elasticity of the DN enables the microcapsules to elastically deform and fully recover the original state for wide ranges of strain and strain rate. Moreover, the DN shells show a threshold force for the shell rupture almost one order of magnitude larger than the SN and maintain their integrity under violent shear flows.
Defect‐Rich Molybdenum Sulfide Quantum Dots for Amplified Photoluminescence and Photonics‐Driven Reactive Oxygen Species Generation
Authors: Zhu Houjuan , Zan Wenyan , Chen Wanli , Jiang Wenbin , Ding Xianguang , Li Bang Lin , Mu Yuewen , Wang Lei , Garaj Slaven , Leong David Tai 
Published: June 2022

AbstractTransition metal dichalcogenide (TMD) quantum dots (QDs) with defects have attracted interesting chemistry due to the contribution of vacancies to their unique optical, physical, catalytic, and electrical properties. Engineering defined defects into molybdenum sulfide (MoS2) QDs is challenging. Herein, by applying a mild biomineralization‐assisted bottom‐up strategy, blue photoluminescent MoS2 QDs (B‐QDs) with a high density of defects are fabricated. The two‐stage synthesis begins with a bottom‐up synthesis of original MoS2 QDs (O‐QDs) through chemical reactions of Mo and sulfide ions, followed by alkaline etching that creates high sulfur‐vacancy defects to eventually form B‐QDs. Alkaline etching significantly increases the photoluminescence (PL) and photo‐oxidation. An increase in defect density is shown to bring about increased active sites and decreased bandgap energy; which is further validated with density functional theory calculations. There is strengthened binding affinity between QDs and O2 due to lower gap energy (∆EST) between S1 and T1, accompanied with improved intersystem crossing (ISC) efficiency. Lowered gap energy contributes to assist e−–h+ pair formation and the strengthened binding affinity between QDs and 3O2. Defect engineering unravels another dimension of material properties control and can bring fresh new applications to otherwise well characterized TMD nanomaterials.
Self‐Powered Smart Shoes with Functional Ribbon Units for Monitoring Human Gait
Authors: Jung In‐Jun , Chang Seung‐Hwan 
Published: June 2022

AbstractThis study presents novel, self‐powered smart shoes that can detect various gait patterns and harvest electrical energy. A functional ribbon unit made of polyvinylidene fluoride (PVDF) ribbon and conductive fabric tape is used for the energy harvester, and a dynamic sensor is used for monitoring the gait patterns. To determine the optimal number of ribbon units and effective elongation levels for energy harvesting, static tensile and repetitive electromechanical tests are performed. In addition, the generated output voltage and energy storage capacity according to the ribbon configuration are experimentally investigated. To enhance the energy‐harvesting efficiency of the functional ribbon unit, a high‐stiffness lightweight carbon composite frame is installed at the heel part inside the smart shoes, and three ribbon units are fastened to it. From the performance test, it is concluded that the harvester generates sufficient electric power, which is stored in successive capacitors; subsequently, the generated electric power is stored in a lithium‐ion battery. Moreover, various gait patterns are successfully identified, and gait speed is estimated using the proposed smart shoes.