bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Saint‐Venant type isoperimetric inequalities for assessing saturated water storage in lacunary shallow perched aquifers
Authors: Avkhadiev Farit G. , Kacimov Anvar R. 
Published: November 2022

AbstractThe Dupuit‐Forchheimer (DF) approximation for unconfined groundwater flows is reduced to 2D Poisson's equation (PE), the right hand side of which involves an intensive evapotranspiration (ET) rate. A shallow water table dips inward from a constant piezometric head boundary (closed curve) such that a “dry gap,” demarcated by another closed curve (unknown front), may emerge. Apriori estimates of the volume of the saturated zone and of the “dry gap” area are important for water resources management in drylands. We use the results from the theory of linear elasticity, torsion of elastic bars, for which PE is solved for the Prandtl function. Using the Poincaré metrics with the Gaussian constant curvature , isoperimetric inequalities are obtained for steady‐state DF flows. Conformal moments and confromal radii of the domains and 2‐D Hardy's type inequalities in domains, modeling the Saint Venant bar torsion problem, are involved in the obtained estimates. The studied boundary value problems (BVPs) are nonlinear for ET rates depending on the depth of the water table. In the DF model, the vadose zone (VZ) is considered as a “distributed sink” (similar to a standard “distributed source,” which models recharge to the water table in humid climates). The analytical VZ is collated with one obtained from a numerical solution to BVP for Richards’ equation in a 3‐D saturated‐unsaturated flow. BVPs for Richards’ equation in cylindrical domains, solved by HYDRUS software, give the pressure head, moisture content, Darcian velocity fields, and streamlines.
Motivation and Application of Haptic Systems
Authors: Kern Thorsten A. , Hatzfeld Christian 
Published: November 2022

AbstractThis chapter serves as an introduction and motivation for the field of haptic research. It provides an overview of the technical domains covered, but also introduces the philosophical and social aspects of human haptic sense. Various definitions of haptics as a perceptual and interaction modality are discussed to serve as a common ground for the rest of the book. Typical application areas such as telepresence, training, interaction with virtual environments and communication are introduced and typical haptic systems from these areas are discussed.
Haptic Software Design
Authors: Abdulali Arsen , Jeon Seokhee 
Published: November 2022

AbstractThis chapter reviews design concepts of haptic modeling and rendering software. The main focus lies in realistic kinesthetic and tactile haptic models for virtual and augmented reality based on the data collected from physical objects. We consider both data-driven algorithms providing a black-box action-response mapping and measurement-based approaches identifying parameters of physics-based models. To show the research landscape and highlight ongoing research challenges, we introduce a series of state-of-the-art methods including data-driven models with deterministic and stochastic responses, physics-based simulation using optimization-based FEM solver, and hybrid approaches of combining the concepts of both data-driven and physics-based methods. These examples also cover a wide range of haptic properties, i.e., modeling and rendering of elasticity and plasticity, tool deformation, and haptic textures.
Examples of Haptic System Development
Authors: Abbasimoshaei Alireza , Meiss Thorsten , Koev Nataliya , Reisinger Jörg 
Published: November 2022

AbstractIn this section, several examples of task-specific haptic systems are given. They shall give an insight in the process of defining haptic interactions for a given purpose and illustrate the development and evaluation process outlined in this book so far. Examples were chosen by the editors to cover different basic system structures.
Conclusion
Authors: Kern Thorsten A. , Hatzfeld Christian , Abbasimoshaei Alireza , Abdulali Arsen , Gölz Jacqueline , Reisinger Jörg , Youssef Fady 
Published: November 2022

AbstractLike any other design process, the design of haptic systems is largely influenced by the optimization of a technical system, which is based on the consideration of a large number of decisions about individual components that usually influence each other.
General System Structures
Authors: Abbasimoshaei Alireza , Kern Thorsten A. 
Published: November 2022

AbstractHaptic systems exhibit several basic structures defined by the mechanical in- and outputs, commonly known as impedance or admittance system structures. This chapter describes these structures in open-loop and closed-loop variants and presents commercial realizations as well as common applications of these structures. Based on the different properties of the structures and the intended application, hints for the selection of a suitable structure are given.
Control of Haptic Systems
Authors: Abbasimoshaei Alireza , Opitz Thomas , Meckel Oliver 
Published: November 2022

AbstractControl engineering is an important part for making the system more precise and provide the possibility for the system to reach the desired parameters. This chapter reviews some aspects of the control in haptic systems, including advanced forms of technical descriptions, system stability criteria and measures as well as the design of different control laws in a haptic system. A focus is set on the control of bilateral teleoperation systems including the derivation of control designs that guarantee stability as well as haptic transparency and the handling of time delay in the control loop. The chapter also includes an example for the consideration of thermal properties and non-ideal mechanics in the control of a linear stage made from an EC motor and a ball screw as well as an perception-orientated approach to haptic transparency intended to lower the technical requirements on the control and component design.
Radiation from axion star-neutron star binaries with a tilted rotation axis in the presence of plasma
Authors: Kyriazis A. 
Published: November 2022

Abstract
We investigate the form of the radiation emitted by an axion star-neutron star binary using a f(r) = sech(r/R) profile for the axion star. Our analysis takes into account the co-rotating plasma of the neutron star. We find that there is significant enhancement to the radiated power if the neutron star’s spin is tilted towards the plane of the axion star-neutron star orbit, compared to the case where it is perpendicular. We also examine whether the neutron star’s co-rotating plasma can play a role in the emitted power and we find that even though dilute axion stars can in principle radiate more efficiently than dense axion stars, they will be pulled apart by the tidal forces of the neutron star.
$$ {U}_{\mathfrak{q}}{\mathfrak{sl}}_2 $$-invariant non-compact boundary conditions for the XXZ spin chain
Authors: Chernyak Dmitry , Gainutdinov Azat M. , Saleur Hubert 
Published: November 2022

Abstract
We introduce new $$ {U}_{\mathfrak{q}}{\mathfrak{sl}}_2 $$

U
q

sl
2

-invariant boundary conditions for the open XXZ spin chain. For generic values of $$ \mathfrak{q} $$
q
we couple the bulk Hamiltonian to an infinite-dimensional Verma module on one or both boundaries of the spin chain, and for $$ \mathfrak{q}={e}^{\frac{i\pi}{p}} $$
q
=

e

iπ
p

a 2p-th root of unity — to its p-dimensional analogue. Both cases are parametrised by a continuous “spin” α ∈ ℂ.To motivate our construction, we first specialise to $$ \mathfrak{q} $$
q
= i, where we obtain a modified XX Hamiltonian with unrolled quantum group symmetry, whose spectrum and scaling limit is computed explicitly using free fermions. In the continuum, this model is identified with the (η, ξ) ghost CFT on the upper-half plane with a continuum of conformally invariant boundary conditions on the real axis. The different sectors of the Hamiltonian are identified with irreducible Virasoro representations.Going back to generic q we investigate the algebraic properties of the underlying lattice algebras. We show that if $$ \mathfrak{q} $$
q
α ∉±$$ \mathfrak{q} $$
q
ℤ, the new boundary coupling provides a faithful representation of the blob algebra which is Schur-Weyl dual to $$ {U}_{\mathfrak{q}}{\mathfrak{sl}}_2 $$

U
q

sl
2

. Then, modifying the boundary conditions on both the left and the right, we obtain a representation of the universal two-boundary Temperley-Lieb algebra. The generators and parameters of these representations are computed explicitly in terms of $$ \mathfrak{q} $$
q
and α. Finally, we conjecture the general form of the Schur-Weyl duality in this case.This paper is the first in a series where we will study, at all values of the parameters, the spectrum and its continuum limit, the representation content of the relevant lattice algebras and the fusion properties of these new spin chains.
PanScales showers for hadron collisions: all-order validation
Authors: van Beekveld Melissa , Ferrario Ravasio Silvia , Hamilton Keith , Salam Gavin P. , Soto-Ontoso Alba , Soyez Gregory , Verheyen Rob 
Published: November 2022

Abstract
We carry out extensive tests of the next-to-leading logarithmic (NLL) accuracy of the PanScales parton showers, as introduced recently for colour-singlet production in hadron collisions. The tests include comparisons to (semi-)analytic NLL calculations of a wide range of hadron-collider observables: the colour-singlet boson transverse momentum distribution; global and non-global hadronic energy flow variables related to jet vetoes and analogues of jettiness distributions; (sub)jet multiplicities; and observables sensitive to the DGLAP evolution of the incoming momentum fractions. In the tests, we also include an implementation of a standard transverse-momentum ordered dipole shower, to establish the size of missing NLL effects in such showers, which, depending on the observable, can reach 100%. This paper, together with [1], constitutes the first step towards process-independent NLL-accurate parton showers for hadronic collisions.
GLI1+ cells are a source of repair-supportive mesenchymal cells (RSMCs) during airway epithelial regeneration
Authors: Chu Xuran , Lingampally Arun , Moiseenko Alena , Kheirollahi Vahid , Vazquez-Armendariz Ana Ivonne , Koepke Janine , Khadim Ali , Kiliaris Georgios , Shahriari Felordi Mahtab , Zabihi Mahsa , Shalashova Irina , Alexopoulos Ioannis , Günther Stefan , Lebrigand Kevin , Truchi Marin , Günther Andreas , Braun Thomas , Mari Bernard , Samakovlis Christos , Li Xiaokun , Seeger Werner , Herold Susanne , Zhang Jin-San , Bellusci Saverio , El Agha Elie 
Published: November 2022

AbstractRepair-supportive mesenchymal cells (RSMCs) have been recently reported in the context of naphthalene (NA)-induced airway injury and regeneration. These cells transiently express smooth muscle actin (Acta2) and are enriched with platelet-derived growth factor receptor alpha (Pdgfra) and fibroblast growth factor 10 (Fgf10) expression. Genetic deletion of Ctnnb1 (gene coding for beta catenin) or Fgf10 in these cells using the Acta2-Cre-ERT2 driver line after injury (defined as NA-Tam condition; Tam refers to tamoxifen) led to impaired repair of the airway epithelium. In this study, we demonstrate that RSMCs are mostly captured using the Acta2-Cre-ERT2 driver when labeling occurs after (NA-Tam condition) rather than before injury (Tam-NA condition), and that their expansion occurs mostly
between days 3 and 7 following NA treatment. Previous studies have shown that lineage-traced peribronchial GLI1+ cells are transiently amplified after NA injury. Here, we report that Gli1 expression is enriched in RSMCs. Using lineage tracing with Gli1Cre−ERT2 mice combined with genetic inactivation of Fgf10, we show that GLI1+ cells with Fgf10 deletion fail to amplify around the injured airways, thus resulting in impaired airway epithelial repair. Interestingly, Fgf10 expression is not upregulated in GLI1+ cells following NA treatment, suggesting that epithelial repair is mostly due to the increased number of Fgf10-expressing GLI1+ cells. Co-culture of SCGB1A1+ cells with GLI1+ cells isolated from non-injured or injured lungs showed that GLI1+ cells from these two conditions are similarly capable of supporting bronchiolar organoid (or bronchiolosphere) formation. Single-cell RNA sequencing on sorted lineage-labeled cells showed that the RSMC signature resembles that of alveolar fibroblasts. Altogether, our study provides strong evidence for the involvement of mesenchymal progenitors in airway epithelial regeneration and highlights the critical role played by Fgf10-expressing GLI1+ cells in this context.
Altered thymocyte development observed in EphA4-deficient mice courses with changes in both thymic epithelial and extracellular matrix organization
Authors: García-Ceca Javier , Montero-Herradón Sara , González Ana , Plaza Rosa , Zapata Agustín G. 
Published: November 2022

AbstractEph receptors and their ligands, Ephrins, are involved in the thymocyte-thymic epithelial cell (TEC) interactions, key for the functional maturation of both thymocytes and thymic epithelium. Several years ago, we reported that the lack of EphA4, a Eph of the subfamily A, coursed with reduced proportions of double positive (DP) thymocytes apparently due to an altered thymic epithelial stroma [Munoz et al. in J Immunol 177:804–813, 2006]. In the present study, we reevaluate the lymphoid, epithelial, and extracellular matrix (ECM) phenotype of EphA4−/− mice grouped into three categories with respect to their proportions of DP thymocytes. Our results demonstrate a profound hypocellularity, specific alterations of T cell differentiation that affected not only DP thymocytes, but also double negative and single positive T cell subsets, as well as the proportions of positively and negatively selected thymocytes. In correlation, thymic histological organization changed markedly, especially in the cortex, as well as the proportions of both Ly51+UEA-1− cortical TECs and Ly51−UEA-1+ medullary TECs. The alterations observed in the expression of ECM components (Fibronectin, Laminin, Collagen IV), integrin receptors (VLA-4, VLA-6), chemokines (CXCL12, CCL25, CCL21) and their receptors (CXCR4, CCR7, CCR9) and in vitro transwell assays on the capacity of migration of WT and mutant thymocytes suggest that the lack of EphA4 alters T-cell differentiation by presumably affecting cell adhesion between TECs and T-TEC interactions rather than by thymocyte migration.
Global weak attractors in the dynamics of bodies with vector-type microstructure
Authors: Bisconti Luca , Mariano Paolo Maria 
Published: November 2022

AbstractWe investigate the dynamics of bodies with vector-type microstructure. We consider linear constitutive relations and a nonlinear coupling between macroscopic and microscopic motions, determined by gyroscopic-type inertia. Based on an existence result obtained in the presence of viscous-type stress components, we determine the existence of a global attractor; its weak nature derives from the lack of uniqueness determined by the nonlinear coupling.
Human metabolism and excretion kinetics of benzotriazole UV stabilizer UV-327 after single oral administration
Authors: Fischer Corinna , Leibold Edgar , Hiller Julia , Göen Thomas 
Published: November 2022

AbstractUV-327 (2-(5-chloro-benzotriazol-2-yl)-4,6-di-(tert-butyl)phenol) is used as an ultraviolet (UV) absorber in plastic products and coatings. Due to its ubiquitous distribution in the environment, human exposure is conceivable. In the study presented herein, initial information on the human in vivo metabolism of UV-327 was obtained by single oral administration to three volunteers. Urine and blood samples were collected up to 72 h after exposure. One study participant additionally donated plasma samples. Maximum blood and plasma levels of UV-327 and its two monohydroxylated metabolites UV-327-6-mOH and UV-327-4-mOH were reached 6 h post-exposure. Almost the entire amount found in blood and plasma samples was identified as UV-327, whereas the two metabolites each accounted for only 0.04% of the total amount, indicating that UV-327 is well-absorbed from the intestine, but only partially metabolized. Plasma to blood ratios of UV-327, UV-327-6-mOH, and UV-327-4-mOH ranged from 1.5 to 1.6. Maximum urinary excretion rates of UV-327, UV-327-6-mOH, UV-327-4-mOH, and UV-327-4 + 6-diOH were reached 9–14 h post-exposure. However, only about 0.03% of the orally administered dose of UV-327 was recovered as UV-327 and its metabolites in urine, indicating that biliary excretion may be the major route of elimination of UV-327 and its hydroxylated metabolites. The present study complements the insight in the complex absorption, distribution, metabolism, and elimination (ADME) processes of benzotriazole UV stabilizers (BUVSs).
Evaluation of double expression system for co-expression and co-immobilization of flavonoid glucosylation cascade
Authors: Matera Agata , Dulak Kinga , Sordon Sandra , Waśniewski Kacper , Huszcza Ewa , Popłoński Jarosław 
Published: November 2022

Abstract

Glucosylation cascade consisting of Leloir glycosyltransferase and sucrose synthase with in situ regeneration system of expensive and low available nucleotide sugars is a game-changing strategy for enzyme-based production of glycoconjugates of relevant natural products. We designed a stepwise approach including co-expression and one-step purification and co-immobilization on glass-based EziG resins of sucrose synthase from Glycine max (GmSuSy) with promiscuous glucosyltransferase YjiC from Bacillus licheniformis to produce efficient, robust, and versatile biocatalyst suited for preparative scale flavonoid glucosylation. The undertaken investigations identified optimal reaction conditions (30 °C, pH 7.5, and 10 mM Mg2+) and the best-suited carrier (EziG Opal). The prepared catalyst exhibited excellent reusability, retaining up to 96% of initial activity after 12 cycles of reactions. The semi-preparative glucosylation of poorly soluble isoflavone Biochanin A resulted in the production of 73 mg Sissotrin (Biochanin A 7-O-glucoside). Additionally, the evaluation of the designed double-controlled, monocistronic expression system with two independently induced promoters (rhaBAD and trc) brought beneficial information for dual-expression plasmid design.

Key points
• Simultaneous and titratable expression from two independent promoters is possible, although full control over the expression is limited.
• Designed catalyst managed to glucosylate poorly soluble isoflavone.
• The STY of Sissotrin using the designed catalyst reached 0.26 g/L∙h∙g of the resin.

Graphical Abstract
[111In]In-CP04 as a novel cholecystokinin-2 receptor ligand with theranostic potential in patients with progressive or metastatic medullary thyroid cancer: final results of a GRAN-T-MTC Phase I clinical trial
Authors: Lezaic Luka , Erba Paola Anna , Decristoforo Clemens , Zaletel Katja , Mikolajczak Renata , Maecke Helmut , Maina Theodosia , Konijnenberg Mark , Kolenc Petra , Trofimiuk-Müldner Malgorzata , Przybylik-Mazurek Elwira , Virgolini Irene , de Jong Marion , Fröberg Alide C , Rangger Christine , Di Santo Gianpaolo , Skorkiewicz Konrad , Garnuszek Piotr , Solnica Bogdan , Nock Berthold A. , Fedak Danuta , Gaweda Paulina , Hubalewska-Dydejczyk Alicja 
Published: November 2022

Abstract
Introduction
Medullary thyroid cancer (MTC) is a rare malignant tumour of the parafollicular C-cells with an unpredictable clinical course and currently suboptimal diagnostic and therapeutic options, in particular in advanced disease. Overexpression of cholecystokinin-2 receptors (CCK2R) represents a promising avenue to diagnostic imaging and targeted therapy, ideally through a theranostic approach.

Materials and methods
A translational study (GRAN-T-MTC) conducted through a Phase I multicentre clinical trial of the indium-111 labelled CP04 ([111In]In-CP04), a CCK2R-seeking ligand was initiated with the goal of developing a theranostic compound. Patients with proven advanced/metastatic MTC or short calcitonin doubling time were enrolled. A two-step concept was developed through the use of low- and high-peptide mass (10 and 50 μg, respectively) for safety assessment, with the higher peptide mass considered appropriate for therapeutic application. Gelofusine was co-infused in a randomized fashion in the second step for the evaluation of potential reduction of the absorbed dose to the kidneys. Imaging for the purpose of biodistribution, dosimetry evaluation, and diagnostic assessment were performed as well as pre-, peri-, and postprocedural clinical and biochemical assessment.

Results
Sixteen patients were enrolled. No serious adverse events after application of the compound at both peptide amounts were witnessed; transient tachycardia and flushing were observed in two patients. No changes in biochemistry and clinical status were observed on follow-up. Preliminary dosimetry assessment revealed the highest dose to urinary bladder, followed by the kidneys and stomach wall. The effective dose for 200 MBq of [111In]In-CP04 was estimated at 7±3 mSv and 7±1 mSv for 10 μg and 50 μg CP04, respectively. Administration of Gelofusine reduced the dose to the kidneys by 53%, resulting in the organ absorbed dose of 0.044±0.019 mSv/MBq. Projected absorbed dose to the kidneys with the use of [177Lu]Lu-CP04 was estimated at 0.9±0.4 Gy/7.4 GBq. [111In]In-CP04 scintigraphy was positive in 13 patients (detection rate of 81%) with superior diagnostic performance over conventional imaging.

Conclusion
In the present study, [111In]In-CP04 was shown to be a safe and effective radiopharmaceutical with promising theranostic characteristics for patients with advanced MTC.
Effects of Dexmedetomidine on Systemic Inflammation and Postoperative Complications in Laparoscopic Pancreaticoduodenectomy: A Double‐blind Randomized Controlled Trial
Authors: Chen Yan‐Xin , Du Lin , Wang Li‐Nan , Shi Yong‐Yong , Liao Min , Zhong Min , Zhao Gao‐Feng 
Published: November 2022

AbstractBackgroundLaparoscopic pancreaticoduodenectomy (LPD) may induce intense inflammatory response which might be related to the patient's outcomes. Clinical dexmedetomidine (DEX) has been widely used for opioid‐sparing anesthesia and satisfactory sedation. The objective of this study was to investigate the influence of DEX on inflammatory response and postoperative complications in LPD.MethodsNinety‐nine patients undergoing LPD were randomly assigned to two groups: normal saline (NS) and DEX. The primary outcome was the neutrophil‐to‐lymphocyte ratio (NLR) differences postoperatively within 48 h. Secondary outcomes were postoperative complications, the length of postoperative hospital stay and the incidence of ICU admission. Other outcomes included anesthetics consumption and intraoperative vital signs.ResultsNLR at postoperative day 2 to baseline ratio decreased significantly in the DEX group (P = 0.032). Less major complications were observed in the DEX group such as pancreatic fistula, delayed gastric emptying and intra‐abdominal infection (NS vs. DEX, 21.7% vs. 13.6%, P = 0.315; 10.9% vs. 2.3%, P = 0.226; 17.4% vs. 11.4%, P = 0.416, respectively) though there were no statistical differences. Three patients were transferred to the ICU after surgery in the NS group, while there was none in the DEX group (P = 0.242). The median postoperative hospital stay between groups were similar (P = 0.313). Both intraoperative propofol and opioids were less in the DEX group (P < 0.05).ConclusionsIntraoperative DEX reduced the early postoperative inflammatory response in LPD. It also reduced the use of narcotics that may related to reduced major complications, which need additional research further.