bluuebunny/crossref_metadata_2025_split huggingface dataset:
Application of the Rate Transient Analysis for Estimation of the Stimulated Reservoir Volume Associated with a Marcellus Shale Horizontal Well
Authors: Parrish Amanda , Sattari Arya , El Sgher Mohamed , Aminian Kashy , Ameri Samuel 
Published: October 2022

Abstract
the Flowing Material Balance (FMB) has become popular in recent years because it does not require static (shut-in) pressure data that are needed for the traditional material balance application. This method is particularly useful for the shale reservoirs where shut-in pressure data are rarely available. The application FMB to the shale reservoirs is challenging because of the presence of the adsorbed gas, due to high organic content, and the long time that is required to establish boundary-dominated flow (BDF) due to ultra-low permeability. However, the interference between the fracture stages in a horizontal well with multiple hydraulic fracture stages leads to an early BDF period during the production. Therefore, the production data from this early BDF period can be utilized to determine the gas in place which can be attributed to the stimulated reservoir volume (SRV) and is of more economic significance.
The objective of this study was to investigate the applicability of the FMB for estimation of the gas in the SRV associated with a Marcellus shale horizontal well with multiple hydraulic fracture stages. The available information from several existing horizontal wells at MSEEL site in West Virginia were utilized to develop a reservoir for model for a Marcellus shale horizontal well with multiple hydraulic fracture stages. To accurately simulate the production data, the adsorbed gas as wells as geomechanical factors, derived from the laboratory and published data, were incorporated in the model. The geomechanical factors account for the impairments in hydraulic fracture conductivity and the reduction in the formation (matrix and fissure) permeability caused by the reservoir depletion. The simulated production data were then analyzed by both conventional method and King method which accounts for gas desorption.
The FMB method which accounts for gas desorption was found to provides reliable estimates of the gas in place in SRV. The analysis of the production data indicated the presence of two BDF. The analysis of the data from the early BDF provided the gas in place in SRV. The analysis of the data from the late BDF provided the total gas in the reservoir. The results were found to be comparable to the values determined from the model. Therefore, the reliability of the data analysis method was confirmed.
Proppant Transport Analysis of the Anionic High Viscosity Friction Reducer in High-TDS Marcellus Shale Formation Water Environments
Authors: Ge Xiaojing , Biheri Ghith , Imqam Abdulmohsin 
Published: October 2022

Abstract
High viscosity friction reducers (HVFRs) have been recently gaining more attention and increasing in use, not only as friction-reducing agents but also as proppant carriers. Reusing of produced water has also been driven by both environmental and economic benefits. In Marcellus Shale regions, slickwater fracturing fluids are commonly used, which reduce the number of fluid additives required and foster high retained conductivity but require high water volumes and pumping rate. In contrast, HVFRs can also exhibit high retained conductivity with less water and horsepower required and much more other operational and economical advantages. Currently, most friction reducers on the market are anionic friction reducers, which are fully compatible with most produced water with low to medium level of Total Dissolved Solids (TDS) but show significant decreasing at high TDS conditions in term of their friction reduction performance in most cases. Concerns remain about performances of using anionic HVFRs with produced water to transport proppant. The ultimate objective of this experimental study is to investigate whether increasing loading of the anionic HVFR can compensate the side effects of high TDS and temperature in Marcellus Shale formation. Anionic HVFRs at 4, 6, and 8 gallons per thousand gallons (GPT) were selected and analyzed. The rheology measurement of different concentrations of anionic HVFRs were conducted with deionized (DI) water, high TDS Marcellus Shale formation water, and 30,000 mg/L NaCl solution at temperature of 60 °C. Static and dynamic proppant settling tests were conducted with various HVFR concentrations at high TDS and temperature conditions. The results showed that high TDS and temperature decreased the viscous and elastic profiles of the anionic HVFR. In particular, the elastic profile became negligible. Differences between monovalent and divalent cations effects on the rheology properties and proppant transport capability of the anionic HVFR were also negligible at high TDS and temperature conditions. Increasing loading of the anionic HVFR had very limited effects on improving its rheology properties and further proppant transport capabilities at Marcellus Shale formation conditions. Therefore, future study can be focused on modifying proppant, such as sizes and concentrations, and slurry injection rate to get better fracturing results in Marcellus Shale formation.
Parameter Estimation of Solar PV Models with an Artificial Humming Bird Optimization Algorithm using Various Objective Functions
Authors: Tummala Ayyarao , kishore indira 
Published: October 2022

Abstract
Accurate photovoltaic (PV) models are essential to optimize grid operations and dynamic energy management. This article proposes parameter estimation of solar PV models using Artificial Humming bird Optimization (AHO) algorithm. The AHO algorithm is inspired by hummingbird flight dynamics and mimics hummingbird foraging behaviour. Three objective functions are developed to minimize the root mean square difference between the experimental and estimated currents. The first objective function is based on the conventional RMSE, while the second is developed using the Lambert W function, and the third is developed using the iterative Newton Raphson approach. The proposed AHO algorithm is applied to estimate the parameters for a single diode model (SDM), a double diode model (DDM), and a PV module. The AHO algorithm achieves an RMSE of 7.2985E-04 for SDM and 7.4080E-04 for DDM. The proposed AHO algorithm's performance is compared to the findings of other algorithms reported in the literature.
Successful creation of CsPb(Br1-xClx)3/ZnS core/shell perovskite nanocrystals for pure deep-blue LEDs with high luminance and efficiency
Authors: Hong Yongju , Yu Chungman , Je Hyeondoo , Kim Taekyung , Baik Hionsuck , Tomboc Gracita Raquel , Kim Youngseo , Ha Jung Min , Joo Jinwhan , Kim Chai Won , Woo Han Young , Park Sungnam , Choi Dong Hoon , Lee Kwangyeol 
Published: October 2022

Abstract
Light-emitting diodes (LEDs) are the rapidly developing core components of current display and lighting technology. Metal halide perovskite nanocrystals (MHP NCs) have recently been used as the deep-blue-light-emitting component in LEDs and are considered to have the greatest potential for growth in practical applications. However, the vulnerability of MHP NCs to the environment and the ion migration during the operation of LEDs pose formidable obstacles to the practical application of MHP NCs. Herein, we show that mixed-halide CsPb(Br1-xClx)3 NCs enclosed by epitaxially grown ZnS shells (CPBC/ZnS) are integral to ensuring a stable perovskite-based deep-blue-light-emitting diode (PeLED). We found that epitaxial ZnS shells protect the MHP NCs from the environment, and that the interparticle ion migration between MHP NCs could be effectively suppressed during LED operation, affording an exceptional external quantum efficiency (EQE) of 3.63% at an emission peak of 451 nm and a maximum luminance of 1687 cd m-2. Our results demonstrate that the epitaxial encapsulation of MHP NCs is a powerful strategy for the fabrication of high-efficiency, high-stability PeLEDs with a deep-blue emission.
New approaches and technical considerations in detecting outlier measurements and trajectories in longitudinal children growth data
Authors: Massara Paraskevi , Asrar Arooj , Bourdon Celine , Ngari Moses , Keown-Stoneman Charles DG , Maguire Jonathon L , Birken Catherine S , Berkley James A , Bandsma Robert HJ , Comelli Elena M 
Published: October 2022

Abstract
Background:Growth studies rely on longitudinal measurements, typically represented as trajectories. However, anthropometry is prone to errors that can generate outliers. While various methods are available for detecting outlier measurements, a gold-standard has not been identified and there is no established method for outlying trajectories. Thus, outlier types and their effects on growth pattern detection remain under-investigated. This work aimed to assess the performance of six methods at detecting different types of outliers, propose two novel methods for outlier trajectory detection, and evaluate how outliers affect growth pattern detection.
Methods: We included 393 healthy infants from The Applied Research Group for Kids (TARGet Kids!) cohort and 1651 children with severe malnutrition from the co-trimoxazole prophylaxis clinical trial. We injected outliers of three types and six intensities, applied four outlier detection methods for measurements (model-based and World Health Organization cut-offs-based) and two for trajectories. We also assessed growth pattern detection before and after outlier injection using time series clustering and latent class mixed models. Error type, intensity, and population affected method performance.
Results: Model-based outlier detection methods performed the best for measurements with precision between 5.72-99.89%, especially for low error intensities and moderate errors. The clustering-based outlier trajectory method had high precision 14.93-99.12%. Combining methods improved detection rate up to 21.82% in outlier measurements. Finally, when comparing growth groups with and without outliers, the outliers were shown to alter group membership by 57.9 -79.04%.
Conclusions: World Health Organization cut-offs-based techniques were shown to perform well on few, very particular cases (extreme errors of high intensity), while model-based techniques performed well, especially for moderate errors of low intensity. Clustering-based outlier trajectory detection performed exceptionally well across all types and intensities of errors, indicating a potential strategic change in how outliers in growth data are viewed. Finally, the importance of detecting outliers was shown given its impact on children growth studies, as shown by comparing results of growth group detection.
Maternal and perinatal outcomes of prolonged second stage of labour: a historical cohort study of over 51,000 women
Authors: Young Catriona , Bhattacharya Sohinee , Woolner Andrea , Ingram Amy , Smith Nicole , Raja Amalraj , Black Mairead 
Published: October 2022

Abstract
Background
Prolonged second stage of labour has been associated with adverse maternal and perinatal outcomes. The maximum length of the second stage from full dilatation to birth of the baby remains controversial. Our objective was to determine whether extending second stage of labour was associated with adverse maternal and perinatal outcomes.
Methods
A retrospective cohort study was conducted using routinely collected hospital data from 51,689 births in Aberdeen Maternity Hospital between 2000 and 2016. The hospital followed the local guidance of allowing second stage of labour to extend by an hour compared to national guidelines since 2008 (nulliparous and parous). The increasing duration of second stage of labour was the exposure. Baseline characteristics, maternal and perinatal outcomes were compared between women who had a second stage labour of (a) ≤ 3 hours and (b) > 3 hours duration for nulliparous women; and (a) ≤ 2 hours or (b)> 2 hours for parous women using univariate analysis. The following were then adjusted for: age, BMI, parity, smoking status, deprivation category, induced birth, epidural, oxytocin, gestational age, baby birthweight and mode of birth. The length of second stage was entered as a continuous variable
Results
Each hourly increase in the second stage of labour was associated with an increased risk of tears (aOR 1.52 95% CI 1.49-1.56), having an episiotomy (aOR 2.10 95% CI 2.06-2.14) and postpartum haemorrhage (aOR 1.55 95% CI 1.53-1.58). The rates of caesarean and forceps delivery also increased threefold when second stage duration increased (aOR 3.38 95% CI 3.26-3.50, aOR 3.18 95% CI 3.11-3.26, respectively.) No statistically significant adverse perinatal outcomes were found on multivariate analysis.
Conclusions
As the duration of second stage of labour increased, the risk of tears, episiotomies and PPH increases significantly. Women were 3 times more likely to have a forceps or caesarean birth. No association was found between adverse perinatal outcomes and the duration of second stage of labour in this study.
Correlation between AI-measured lacquer cracks extension and development of myopic choroidal neovascularization
Authors: Crincoli Emanuele , Miere Alexandra , Ferrara Silvia , Sacconi Riccardo , Battista Marco , Catania Fiammetta , Souied Eric H. , Querques Giuseppe 
Published: October 2022

Abstract
Objectives
To investigate the correlation between the AI-measured area of the lacquer cracks (LC) at their first detection and the occurrence of a choroidal neovascularization (CNV) during the follow up in patients affected by pathologic myopia. Secondary outcome was the detection of a correlation between the time to onset of CNV with both baseline LC area and LC area increase during follow up.
Methods
Optical coherence tomography (OCT) acquisitions of patients diagnosed with LC were retrospectively analyzed. The study population was divided in a CNV group (showing documented onset of a CNV) and a n-CNV group (no CNV development during follow-up). LC area was measured using MatLab software after application of a customized method for LC segmentation on infrared (IR) enface images.
Results
Fifty-five (55) patients with a mean follow-up of 5.1 ± 1.4 years were included. LC area at baseline was 2.82 ± 0.54 mm2 and 1.57 ± 0.55 mm2 in CNV (20 patients) and n-CNV group (35 patients) group respectively (p < 0.001). LC area increase was significantly higher in CNV group (p = 0.009). Time to onset of CNV was linearly correlated with both LC area at baseline (p = 0.006) and LC area increase (p < 0.001).
Conclusions
Myopic CNV development is associated with lager LC areas and higher LC area increase during time. Earlier CNV onset is inversely correlated with LC area and LC area increase.
Perfect Crystals: Microgravity capillary counterdiffusion crystallization of human manganese superoxide dismutase for neutron crystallography
Authors: Borgstahl Gloria , Lutz William , Azadmanesh Jahaun , Lovelace Jeffrey , Kolar Carol , Coates Leighton , Weiss Kevin 
Published: October 2022

Abstract
The NASA mission Perfect Crystals used the microgravity environment on the International Space Station (ISS) to grow crystals of human manganese superoxide dismutase (MnSOD) - an oxidoreductase critical for mitochondrial vitality and human health. The mission’s overarching aim is to perform neutron protein crystallography (NPC) on MnSOD to directly visualize proton positions and derive a chemical understanding of the concerted proton electron transfers performed by the enzyme. Large crystals that are perfect enough to diffract neutrons to sufficient resolution are essential for NPC. This combination, large and perfect, is hard to achieve on Earth due to gravity-induced convective mixing. Capillary counterdiffusion methods were developed that provided a gradient of conditions for crystal growth along with a built-in time delay that prevented premature crystallization before stowage on the ISS. Here, we report a highly successful and versatile crystallization system to grow a plethora of crystals for high-resolution NPC.
Multicenter Randomized Controlled Trial comparing Oral Chloral Hydrate and Intranasal combination of Dexmedetomidine and Ketamine for Procedural Sedation in Children: study protocol
Authors: Jang Young-Eun , Joo Eun-Young , Lee Ji-Hyun , Kim Eun-Hee , Kang Pyoyoon , Park Jung-Bin , Kim Hee-Soo , Kim Jin Tae 
Published: October 2022

Abstract
Background

Oral chloral hydrate is widely used in pediatric sedation. Intranasal dexmedetomidine has been increasingly used for pediatric sedation; however, its improvement is warranted. The combination of dexmedetomidine with ketamine can improve onset and hemodynamic stability while maintaining sedative efficacy. This study aims to determine the efficacy and safety of intranasal combination of dexmedetomidine and ketamine compared to oral chloral hydrate.

Methods

This is a prospective, parallel-arm, single-blinded, multi-center, randomized controlled trial with 1:1 allocation, designed to compare the effects of intranasal combination of dexmedetomidine and ketamine with those of oral chloral hydrate. We shall enrol 136 patients aged < 7 years old in this study. Prior to the procedure, we shall randomise each patient into the control group (oral chloral hydrate 50 mg/kg) or study group (intranasal dexmedetomidine 2 µg/kg and ketamine 3 mg/kg). The primary outcome will be the rate of achieving an adequate sedation level (6-point Pediatric Sedation State Scale 1, 2, or 3) within 15 min. In addition, we shall measure the sedation time, sedation failure rate, completion of procedure, adverse events, patient acceptance, and physician satisfaction.

Discussion

This study will provide evidence of the efficacy and safety of the intranasal combination of dexmedetomidine and ketamine in comparison with oral chloral hydrate.

Trial registration

: ClinicalTrials.gov, NCT04820205. Registered on 19th March 2021
LINC01468 drives NAFLD-HCC progression through CUL4A-linked degradation of SHIP2
Authors: Tang Bo , wang Hongquan , Wang Yan , Lai Shihui , Zhao Liang , Liu Wenhui , Liu Shiqian , Chen Haiqiang , Wang Jinhua , Du Guan-Hua 
Published: October 2022

Abstract

Accumulating evidence suggests that long noncoding RNAs (lncRNAs) are deregulated in hepatocellular carcinoma (HCC) and play a role in the pathogenesis of non-alcoholic fatty liver disease (NAFLD). However, the current understanding of the role of lncRNAs in NAFLD-associated HCC is limited. In this study, transcriptomic profiling analysis of three paired human liver samples from patients with NAFLD-driven HCC and adjacent samples showed that LINC01468 expression was significantly upregulated.In vitroandin vivogain- and loss-of-function experiments showed that LINC01468 promotes the proliferation of HCC cells through lipogenesis. Mechanistically, LINC01468 binds SHIP2 and promotes cullin 4A (CUL4A)-linked ubiquitin degradation, thereby activating the PI3K/AKT/mTOR signaling pathway, resulting in the promotion ofde novolipid biosynthesis and HCC progression. Importantly, the SHIP2 inhibitor reversed the sorafenib resistance induced by LINC01468 overexpression. Moreover, ALKBH5-mediated N6-methyladenosine (m6A) modification led to stabilization and upregulation of LINC01468 RNA. Taken together, the findings indicated a novel mechanism by which LINC01468-mediated lipogenesis promotes HCC progression through CUL4A-linked degradation of SHIP2. LINC01468 acts as a driver of HCC progression from NAFLD, highlights the potential of the LINC01468-SHIP2 axis as a therapeutic target for HCC.
EDIL3 is a Potential Prognostic Biomarker and Correlates with Immune Infiltrates in Gastric Cancer
Authors: Ke Bin , Liang Zheng-Kai , Li Bin , Wang Xue-Jun , Liu Ning , Liang Han , Zhang Ru-Peng 
Published: October 2022

Abstract
Epidermal Growth Factor-like repeats and Discoidin I-Like Domains 3 (EDIL3) is a secretory protein that play important roles in embryonic development and various illnesses such as cancer. However, the biological function of EDIL3 in gastric cancer (GC) is still unclear. In this study, the GEPIA, HPA, MethSurv, SMART, STRING, GeneMANIA, LinkedOmics TIMER, TIMER2.0, TISIDB, and RNAactDrug databaseswere used to comprehensively analyze the roles of EDIL3 in GC. To validate the in silico findings, EDIL3 expression was measured in our collected GC tissues. Meanwhile, several in vitro experiments were performed to test the function of EDIL3 in GC. We found that EDIL3 was highly expressed in GC and associated with adverse clinical features. In vitro assays revealed that EDIL3 promotes the proliferation, migration, and invasion of GC cells. The functions of EDIL3 and co-expression genes were significantly associated with extracellular structure organization and extracellular matrix receptor interaction. EDIL3 expression was positively associated with numerous tumour-infiltrating immune cells and their biomarkers. In conclusion, this study demonstrated that EDIL3 might function as an oncogene and is associated with immune infiltration in GC. EDIL3 could be used as a potential therapeutic target for GC.
Systematic Review: Interventions to Quit Tobacco Products for Young Adults
Authors: Park Eunhee , Zhou Yanjun , Chen Chia-Hui , Chacko Thomas , Mahoney Martin , Chang Yu-Ping 
Published: October 2022

Abstract
Introduction: Young adulthood is an important period for smoking cessation; however, there is limited evidence of smoking-cessation interventions for young adults. The aims of this study were to identify evidence-based smoking-cessation strategies for young adults, examine gaps in the literature regarding smoking cessation among young adults, and discuss methodological issues/challenges related to smoking-cessation studies for young adults.
Methods: Studies tested interventions for smoking cessation among young adults (18 to 26 years old), excluding pilot studies. Five main search engines were used, including PubMed, the Cumulative Index of Nursing and Allied Health Literature (CINAHL), EMBASE, PsycINFO, and Web of Science. The search was conducted for articles published from January 2009 to December 2019. Intervention characteristics and cessation outcomes were reviewed, and methodological quality was evaluated.
Results: A total of 14 articles met inclusion criteria, including randomized controlled studies and repeated cross-sectional studies. Interventions included the following: text messaging (4/14, 28.6%), social media use (2/14, 14.3%), web-or app-based intervention (2/14, 14.3%), telephone counseling (1/14, 7.1%), in-person counseling (3/14, 21.4%), pharmacological (1/14, 7.1%), and self-help booklet (1/14, 7.1%). The intervention duration and frequency of contact with participants differed and yielded varied outcomes.
Conclusions: Multiple interventions are used for young adults’ smoking cessation. Available literature is inconclusive about the type of intervention that is most effective for young adults. However, the following interventions showed promising results based on RCT studies: text-based, social media, phone call, booklet-based counseling, and pharmacological. Future studies must compare the relative effectiveness of these intervention modalities.