bluuebunny/crossref_metadata_2025_split huggingface dataset:
3D modeling of the impact of ancient Yellow River floods on urban landscapes: A new look at the late imperial landscape at the Shuntianmen Site of Kaifeng City, Henan Province, China
Authors: Panpan Chen , Peng Lu , Ruixia Yang , Storozum Michael J. , Yingzhuo Zhang , Qifeng Ge , Cheng Wang , Lijie Yan , Xia Wang , Lanbo Guo , Zhen Wang , Haiguo Zhai 
Published: August 2022

AbstractFloods had a massive impact on the development of ancient cities around the world and understanding this phenomenon constitutes an essential part of the history of long‐term and dynamic human–environment interactions. There remains, however, an enormous challenge in identifying records of ancient floods in urban environments due to various sedimentation and postdepositional processes that often remove, erase, and alter such environmental records. During archaeological excavations in the famous historic city of Kaifeng, we identified records of two historical floods at the Shuntianmen site. Related stratums were carefully studied, from which dating and sediment samples were collected. These excavated stratums were also scanned to obtain digital data for modeling. Combining these data, we then applied three‐dimensional modeling to reconstruct the evolution of the natural and cultural landscape of the site since the Northern Song Dynasty (960–1127 AD), which was not possible in previous studies due to the deep burial of archaeological strata. Our results indicate that the two floods occurred during the late Ming Dynasty (1368–1644 AD) and the Qing Dynasty (1636–1912 AD), respectively. During the Northern Song Dynasty, Shuntianmen was an important part of Kaifeng, which was, at that time, the capital of China and one of the largest cities in the world. Later, during the Yuan and Ming dynasties, Shuntianmen became a suburban settlement situated along various traffic routes. During the Qing Dynasty, the area became a small village. Subsequently, the area was completely abandoned and deserted until modern Kaifeng, which was built at the same place. The evolution of the regional landscape is the direct result of the interaction between the natural environment and human activities, among which the precarious alluvial processes of the Yellow River were playing an increasingly vital role. Over the centuries, the Yellow River floods, warfare, and wind‐blown sand accumulation reduced the Kaifeng region from a prosperous capital to a comparatively deserted area.
Postoperative outcomes in robotic gastric resection compared with laparoscopic gastric resection in gastric cancer: A meta‐analysis and systemic review
Authors: Ali Muhammad , Wang Yang , Ding Jianyue , Wang Daorong 
Published: August 2022

AbstractBackgroundRobotic gastrectomy is a commonly used procedure for early gastric cancer and it also overcomes the limitation of laparoscopic. However, the complications of robotic gastrectomy (RG) still need to be assessed. Our study was designed to compare postoperative complications of RG with laparoscopic gastrectomy (LG).Materials and MethodsA meta‐analysis and systemic review were prospectively collected using the PubMed, Cochrane Library, and MEDLINE database of published studies by comparing the RG and LG with gastric cancer up to December 2021. To evaluate the postoperative outcomes, odds ratios were calculated for Dichotomous data and the mean difference with 95% confidence interval (CI) was calculated for continuous data, and measured by the random‐effect model.ResultsThirty‐two retrospective studies describing 13,585 patients (4484 RG and 9101 LG) satisfied the inclusion criteria. A statistically significant result was in blood loss (MD = −17.97, 95% Cl: −25.61 to 10.32, p < 0.001), Clavien−Dindo grade Ⅲ (odds ratio (OR) = 0.60, 95% CI: 0.48−0.76, p < 0.01), and harvested lymph node (MD = 2.62, 95% CI: 2.14−3.11, p < 0.001). There was no significant difference between robotic gastrectomy surgery (RGS) and laparoscopic gastrectomy surgery (LGS) regarding distal resection margin (DRM), proximal resection margin (PRM), conversion rate, anastomotic leakage, and overall complications.ConclusionHaving significant outcomes in Clavien–Dindo grade III, and blood loss, harvested lymph nodes are more common in RGS, and they also help in increasing the quality of life.
Identification of an immune‐related gene signature as a prognostic target and the immune microenvironment for adrenocortical carcinoma
Authors: Xu Chengdang , Qin Caipeng , Jian Jingang , Peng Yun , Wang Xinan , Chen Xi , Wu Denglong , Song Yuxuan 
Published: August 2022

AbstractBackgroundAdrenocortical carcinoma (ACC) is a rare endocrine malignancy. Even with complete tumor resection and adjuvant therapies, the prognosis of patients with ACC remains unsatisfactory. In the microtumor environment, the impact of a disordered immune system and abnormal immune responses is enormous. To improve treatment, novel prognostic predictors and treatment targets for ACC need to be identified. Hence, credible prognostic biomarkers of immune‐associated genes (IRGs) should be explored and developed.Material and methodsWe downloaded RNA‐sequencing data and clinical data from The Cancer Genome Atlas (TCGA) data set, Genotype‐Tissue Expression data set, and Gene Expression Omnibus data set. Gene set enrichment analysis (GSEA) was applied to reveal the potential functions of differentially expressed genes.ResultsGSEA indicated an association between ACC and immune‐related functions. We obtained 332 IRGs and constructed a prognostic signature on the strength of 3 IRGs (INHBA, HELLS, and HDAC4) in the training cohort. The high‐risk group had significantly poorer overall survival than the low‐risk group (p < .001). Multivariate Cox regression was performed with the signature as an independent prognostic indicator for ACC. The testing cohort and the entire TCGA ACC cohort were utilized to validate these findings. Moreover, external validation was conducted in the GSE10927 and GSE19750 cohorts. The tumor‐infiltrating immune cells analysis indicated that the quantity of T cells, natural killer cells, macrophage cells, myeloid dendritic cells, and mast cells in the immune microenvironment differed between the low‐risk and high‐risk groups.ConclusionOur three‐IRG prognostic signature and the three IRGs can be used as prognostic indicators and potential immunotherapeutic targets for ACC. Inhibitors of the three novel IRGs might activate immune cells and play a synergistic role in combination therapy with immunotherapy for ACC in the future.
WD repeat domain 6 as a novelty prognostic biomarker correlates with immune infiltration in lung cancer: A preliminary study
Authors: Lv Minghe 
Published: August 2022

AbstractBackgroundWD repeat domain 6 (WDR6), a novel human WD‐repeat gene, encodes a member of the WD repeat protein family, and its tumorigenic effect has rarely been reported so far.MethodsOur study used Oncomine, TIMER2.0, GEPIA2, Kaplan–Meier plotter, PrognoScan, and TISIDB tools to analyze the differential expression between pan‐cancer, especially lung cancer, and corresponding normal tissue, and further explore the prognostic and immunological role of WDR6 expression.ResultsOur results showed WDR6 was lower expressed in lung squamous cell carcinoma than in normal tissue, but WDR6 expression was correlated obviously with clinical stage in Lung adenocarcinoma. The overall survival, first progression, postprogression survival, and Relapse‐free survival of lung cancer patients were longer in the WDR6 high‐expression group than in the low‐expression group. We found the expression of WDR6 significantly correlated with immune molecules, including immunomodulators, lymphocytes, and chemokines in lung cancer.ConclusionWDR6 can be used as a prognostic marker for lung cancer and is significantly associated with immune cell infiltration.
Voyage of selenium from environment to life: Beneficial or toxic?
Authors: Banerjee Manisha , Chakravarty Dhiman , Kalwani Prakash , Ballal Anand 
Published: August 2022

AbstractSelenium (Se), a naturally occurring metalloid, is an essential micronutrient for life as it is incorporated as selenocysteine in proteins. Although beneficial at low doses, Se is hazardous at high concentrations and poses a serious threat to various ecosystems. Due to this contrasting ‘dual' nature, Se has garnered the attention of researchers wishing to unravel its puzzling properties. In this review, we describe the impact of selenium's journey from environment to diverse biological systems, with an emphasis on its chemical advantage. We describe the uneven distribution of Se and how this affects the bioavailability of this element, which, in turn, profoundly affects the habitat of a region. Once taken up, the subsequent incorporation of Se into proteins as selenocysteine and its antioxidant functions are detailed here. The causes of improved protein function due to the incorporation of redox‐active Se atom (instead of S) are examined. Subsequently, the reasons for the deleterious effects of Se, which depend on its chemical form (organo‐selenium or the inorganic forms) in different organisms are elaborated. Although Se is vital for the function of many antioxidant enzymes, how the pro‐oxidant nature of Se can be potentially exploited in different therapies is highlighted. Furthermore, we succinctly explain how the presence of Se in biological systems offsets the toxic effects of heavy metal mercury. Finally, the different avenues of research that are fundamental to expand our understanding of selenium biology are suggested.
Ischemic preconditioning/ischemic postconditioning alleviates anoxia/reoxygenation injury via the Notch1/Hes1/VDAC1 axis
Authors: Wang Lijun , Lai Songqing , Zou Huaxi , Zhou Xueliang , Wan Qing , Luo Yong , Wu Qicai , Wan Li , Liu Jichun , Huang Huang 
Published: August 2022

AbstractIschemic preconditioning (IPC), and ischemic postconditioning (IPost) have a significant protective effect on myocardial ischemia/reperfusion (MI/R) injury by alleviating oxidative stress and mitochondrial disturbances, although the underlying molecular mechanisms are unclear. The study was to demonstrate that cardioprotection against anoxia/reoxygenation (A/R) injury is transduced via the Notch1/Hes1/VDAC1 signaling pathway. Using mass spectrometry and tandem affinity purification (TAP), to screen for differentially expressed proteins associated with Hes1, followed by standard bioinformatics analysis. The co‐immunoprecipitation (Co‐IP) assay confirmed an interaction between Hes1 and VDAC1 proteins. H9c2 cells were transfected with Hes1 adenoviral N‐terminal TAP vector (AD‐NTAP/Hes1) and Hes1‐short hairpin RNA adenoviral vector (AD‐Hes1‐shRNA) to establish A/R injury, IPC, and IPost models, respectively. The expression of Hes1 and VDAC1 proteins were measured by western blot analysis, while the levels of reactive oxygen species (ROS), mitochondrial membrane potential (ΔΨm), and apoptosis were evaluated by flow cytometry. AD‐NTAP/Hes1 can activate the exogenous protein expression of Hes1, thus decreasing creatine phosphokinase (CPK) and lactate dehydrogenase (LDH) activity and promoting cell viability. The study found that VDAC1 was a potential target protein for Hes1 and the overexpression of Hes1 protein expression downregulated protein expression levels of VDAC1, reduced ROS production, stabilized ΔΨm, and inhibited apoptosis in H9c2 cells. Additionally, downregulation of Hes1 protein expression also upregulated VDAC1 protein expression, increased ROS production, imbalanced ΔΨm, promoted cell apoptosis, and attenuated the cardioprotection afforded by IPC and IPost. The Notch1/Hes1 signaling pathway activated by IPC/IPost can directly downregulate the protein expression of VDAC1 and consequently relieve A/R injury.
Age and depressive symptoms change predict the 4‐year self‐concept trajectory for youth after anxiety treatment
Authors: Fjermestad Krister W. , Bellika Katarina , Matre Caroline , Silverman Wendy K. , Wergeland Gro Janne 
Published: August 2022

AbstractObjectivesTo investigate the self‐concept trajectory from before to 4 years after cognitive behavioral therapy (CBT) for youth with anxiety disorders, including predictors.MethodsYouth with anxiety diagnoses (N = 179; M = 11.5 years, SD = 2.1; 53.6% girls; 46.4% boys) received CBT in community clinics. Self‐concept, anxiety/depression symptoms, and diagnostic status were assessed at pre‐, post, 1‐year, and 4‐year posttreatment.ResultsGrowth curve analyses showed that the self‐concept improved significantly over time (d = 0.07 to 0.34). Higher age and a decrease in the depressive symptom trajectory predicted increased self‐concept trajectory from baseline to 4 years posttreatment. Not dropping out of treatment also contributed positively to the self‐concept trajectory, but not above and beyond decreased depressive symptoms. The correlation between self‐concept and depressive symptoms was r = 0.60, indicating these are related but distinct.ConclusionSelf‐concept can improve after CBT, also long‐term. This change appears to primarily be associated with decreased depressive symptoms over time.
Eating disorder psychopathology and resilience in Iranian college students: A network analysis
Authors: Sahlan Reza N. , Sala Margaret 
Published: August 2022

AbstractObjectiveEating disorder (ED) psychopathology is common among Iranian college students. Resilience (i.e., the ability to bounce back and adapt in the face of adverse and stressful conditions) has been found to be a protective factor against ED psychopathology in the West. However, no research to date has examined resilience as a protective factor against ED psychopathology in Iran. The current study used network analysis to examine an ED and resilience network in an Iranian sample.MethodParticipants were Iranian college students (N = 478) who completed the Farsi‐Eating Disorder Examination‐Questionnaire and Farsi‐Brief Resilience Scale. We estimated a network of ED symptoms and resilience processes and identified central and bridge symptoms.ResultsCentral ED and resilience nodes were discomfort in seeing one's own body, feeling guilty about eating due to shape/weight, and thinking about shape and weight making it difficult to concentrate. Having a hard time making it through stressful events bridged with binge eating and fear of losing control over eating.ConclusionProcesses related to managing stress and binge eating appear to maintain the association between ED symptoms and resilience processes.
Personality and mentalization: A latent profile analysis of mentalizing problematics in adult patients
Authors: Gagliardini Giulia , Gullo Salvatore , Teti Arianna , Colli Antonello 
Published: August 2022

AbstractBackgroundThe aim of this study was to investigate the relationship between patients' mentalizing problematics and their personality; specifically, it aimed to identify clusters of individuals characterized by specific patterns of mentalizing imbalances and to analyze the relationship between these and diagnosis of personality disorder (PD), nonmentalizing modes, emotion dysregulation, and interpersonal reactivity.MethodsFour hundred therapeutic dyads were recruited. A part of these (n = 183) only completed clinician‐report measures, Mentalization Imbalances Scale, and Modes of Mentalization Scale, while others (n = 217) also completed patients' self‐report measures, which were Reflective Functioning Questionnaire, Difficulties in Emotion Regulation Scale, and Interpersonal Reactivity Index.ResultsA latent profile analysis enlightened the presence of four clusters with problematics in the dimensions of mentalization, indicated by cluster names: (1) Affective‐self‐automatic profile (ASA‐P) (with higher percentage of PDs); (2) External profile (E‐P) (with lower percentage of PDs); (3) Others‐automatic‐affective profile (OAA‐P); (4) Cognitive‐self‐automatic profile (CSA‐P). Multivariate analysis of variances confirmed that the four clusters differed in relation to the quality of mentalization, emotional dysregulation and interpersonal reactivity, with higher levels of nonmentalization modes, uncertainty about mental states and emotion dysregulation in ASA‐P, higher levels of good mentalization in E‐P, lower impulsivity in CSA‐P, and greater empathic concern in OAA‐P.
“You say you're inclusive, but can you show us?” The importance of cultural competence when working with sexual minorities in a mental health setting
Authors: Bishop Joshua , Crisp Dimity A. , Grant Janie Busby , Scholz Brett 
Published: August 2022

AbstractObjectivesSexual minorities experience higher rates of psychological distress than heterosexual people, likely due to minority stress. While rates of help‐seeking by sexual minorities are high, sexual minorities report greater dissatisfaction with mental health service providers. This dissatisfaction may result from poor cultural competence practices. Our study sought to determine the importance of service provider cultural competence practices to a community sample of sexual minority people.MethodsParticipants (n = 274) were sexual minority Australians recruited from affirming Facebook groups, organizations, and research‐based organizations. To measure the importance of cultural competence practices, participants completed a modified online version of the Gay Affirming Practices Scale (GAP) and responded to open‐ended questions.ResultsBetween 80% and 99% of participants endorsed each item on the GAP, indicating the importance of service providers demonstrating an array of culturally affirming practices. No significant associations were found between overall GAP score and age or sexual orientation, though further analyses revealed individual items on the GAP showed associations with age. A structured tabular thematic analysis, of open‐ended participant responses, found positive attitudes, knowledge, and affirming practices were the three most important characteristics for service providers seeking to demonstrate culturally competent practices, mirroring the tripartite model (attitudes, knowledge, and skills) of cultural competence.ConclusionRecommendations for service providers to demonstrate cultural competence include: utilizing affirming practices such as inclusive language, increasing knowledge about sexual minorities, and utilizing education resources such as cultural competence workshops, lived experience stories, and seeking mentorship from service providers with expertise in working with sexual minorities.
Is there benefit to concurrent x‐ray imaging of the wrist, forearm and elbow in paediatric patients following a fall on the outstretched hand?
Authors: Sgualdino Daniel G , Neep Michael J , Spuur Kelly , Hughes Clarissa 
Published: August 2022

AbstractIntroductionConcurrent X‐ray imaging of the wrist, forearm and elbow in paediatric patients following a fall on the outstretched hand (FOOSH) is intended to minimise the risk of an undetected co‐occurring injury and is typically performed on patients aged 0–10 years. The purpose of this study was to explore the benefit of this strategy and to identify if age could provide evidence for imaging.MethodsA 12‐month retrospective review of all X‐ray examinations of the wrist, forearm and distal humerus of patients aged 0–10 years referred from the Emergency Department of Logan Hospital, Queensland was undertaken. The frequency, type and location of radiographic abnormalities and the requested examinations region of interest (ROI), referral notation and patient's age were recorded. Analysis was made by descriptive statistics.ResultsFour hundred and seventy‐six examinations met the studies inclusion criteria, 4.8% (n = 23) identified an abnormality outside of the documented ROI. On review of the admission and treatment notes, 1.7% (n = 8) were deemed to have detected traumatic abnormalities as a direct outcome of concurrent imaging. No age‐related evidence for imaging was identified.ConclusionThis study demonstrates limited benefit (1.7%) to concurrent imaging following a FOOSH. The results suggest that a thorough physical evaluation of the paediatric upper limb performed by the referrer is sufficient to accurately guide X‐ray imaging. These findings have the potential to positively impact a reduction in the number of X‐rays performed on paediatric patients and in turn contribute to limiting radiation dose. Further studies may be beneficial in verifying the study's findings.
Screening of undernutrition in children with Hirschsprung disease using preoperative anthropometric parameters: A multicenter cross‐sectional study
Authors: Wang Di , Zhu Tianqi , Zhu Liye , Ji Chunyi , Zhou Bingyan , Zhang Guofeng , Yin Qiang , Yang Heying , Feng Jiexiong 
Published: August 2022

AbstractBackgroundThe prevalence of malnutrition is unknown in patients with Hirschsprung disease. Undernutrition is associated with poor clinical outcomes. This study aims to describe the nutrition status among patients with Hirschsprung disease at admission.MethodsWe retrospectively used data from children with Hirschsprung disease admitted to three pediatric surgery centers in China from January 2016 to December 2020. The weight‐for‐age z scores (WAZ), height‐for‐age z scores (HAZ), and body mass index‐for‐age z scores (BAZ) were calculated as the reference for nutrition risk according to the World Health Organization child growth standards. The nutrition status of enrolled children was described and nutrition risk in each clinical characteristic was compared. The association between nutrition status and clinical outcomes was analyzed using univariate and multivariate logistic regression.ResultsA total of 624 patients were included in this study. The mean WAZ, HAZ, and BAZ of all patients was −0.64 ± 1.40, −0.45 ± 1.78, and −0.43 ± 1.50, respectively. Moderate to severe overall undernutrition was 16.3% (102/624). We found that WAZ and BAZ were significantly reduced with the length of aganglionic segments (P = 0.001). Children who had a definitive surgery at 3 years of age or older had significantly lower HAZ (P = 0.001). A multivariate regression model assessing postoperative Hirschsprung‐associated enterocolitis showed that the WAZ was one of the independent risk factors (P = 0.001).ConclusionUndernutrition is prevalent among children with Hirschsprung disease. Nutrition assessment to identify individuals at risk of undernutrition for further intervention is necessary.