bluuebunny/crossref_metadata_2025_split huggingface dataset:
An optimization method for untargeted MS-based isotopic tracing investigations of metabolism
Authors: Butin Noémie , Bergès Cécilia , Portais Jean-Charles , Bellvert Floriant 
Published: June 2022

Abstract
Introduction
Stable isotope tracer studies are increasingly applied to explore metabolism from the detailed analysis of tracer incorporation into metabolites. Untargeted LC/MS approaches have recently emerged and provide potent methods for expanding the dimension and complexity of the metabolic networks that can be investigated. A number of software tools have been developed to process the highly complex MS data collected in such studies; however, a method to optimize the extraction of valuable isotopic data is lacking.

Objectives
To develop and validate a method to optimize automated data processing for untargeted MS-based isotopic tracing investigations of metabolism.

Methods
The method is based on the application of a suitable reference material to rationally perform parameter optimization throughout the complete data processing workflow. It was applied in the context of 13C-labelling experiments and with two different software, namely geoRge and X13CMS. It was illustrated with the study of a E. coli mutant impaired for central metabolism.

Results
The optimization methodology provided significant gain in the number and quality of extracted isotopic data, independently of the software considered. Pascal triangle samples are well suited for such purpose since they allow both the identification of analytical issues and optimization of data processing at the same time.

Conclusion
The proposed method maximizes the biological value of untargeted MS-based isotopic tracing investigations by revealing the full metabolic information that is encoded in the labelling patterns of metabolites.
Two constructed wetlands within a Mediterranean natural park immersed in an agrolandscape reduce most heavy metal water concentrations and dampen the majority of pesticide presence
Authors: Rodrigo Maria A. , Puche Eric , Carabal Nuria , Armenta Sergio , Esteve-Turrillas Francesc A. , Jiménez Javier , Juan Fernando 
Published: June 2022

AbstractThe water concentrations of 12 heavy and other metals/metalloids were analyzed seasonally along two horizontal-flow constructed wetlands (CWs) (Tancat Mília—TM and Tancat l’Illa—TLI) located within the Mediterranean Albufera de València Natural Park during 2020–2021. A wide-scope screening of pesticides present in waters was also performed. The two CWs were created to improve water quality and increase biodiversity. They currently receive effluent waters from two different tertiary-treatment wastewater plants, and the water flows along the CWs before being discharged into the main lagoon and a smaller lagoon in TM and TLI, respectively. TLI manages to reduce (Mn) or maintain the concentration of most of the studied elements (Zn, Ni, Hg, Cr, Fe Cd, Cu) at the same level as outside (67%). Only Al, Pb, B, and As remain at a higher concentration. TM also reduces Zn and Cu and keeps the concentration of Cr, Cd, and Hg (representing 42%). Al, Pb, B, and As remain at higher concentrations, as in TLI, but Ni, Fe, and Mn are also at higher concentrations. Although both CWs vary in their ability to remove elements, no risks to human health or the environment have been detected due to the low metal concentration in their outlets, all of them (except Hg) below the legal limits for environmental quality in the European Union. With the detection of 71 compounds in water in each CW area (26 herbicides, 26 insecticides, and 19 fungicides in TLI, and 29 herbicides, 23 insecticides, and 19 fungicides in TM), we also provide evidence of the impact of pesticides, which depends on the application method (helicopter, tractor), originated from areas with high agricultural pressure (chiefly rice crops) on systems (mainly TM) created to preserve biodiversity. Nevertheless, both systems provide crucial environmental services in water quality in this agrolandscape.
The impact of unilateral BIT terminations on FDI: Quasi-experimental evidence from India
Authors: Hartmann Simon , Spruk Rok 
Published: June 2022

AbstractThis study identifies the impact of Bilateral Investment Treaties (BITs) on foreign direct investments (FDI) by taking advantage of the random timing of 44 unilateral BIT terminations in India between 2013 and 2019. Using quarterly bilateral data of 138 foreign investors’ home countries (FIHCs), our difference-in-differences (DD) estimates uncover a significant reduction in FDI inflows to India in response to BIT terminations by more than 30 percent compared to countries without terminations. We identify the sudden break with investor protection for new investments as the major transmission channel. Further investigations suggest that investors do not necessarily abandon India in response to BIT terminations but apparently reroute FDI via FIHCs with BITs. Evidence from firm-level data reveals that investors revoke or reroute mainly deals (e.g. mergers and acquisitions) rather than own new projects. Moreover, similarity of some legal institutions with India offsets the negative effect of BIT terminations.
F-18-FDG PET/CT findings of paraneoplastic dermatoses
Authors: Suga Kazuyoshi 
Published: June 2022

AbstractParaneoplastic dermatoses (PD) are defined as nonspecific skin disorders which are associated with internal neoplasms, but without direct association to primary tumors or metastases. Recognition of PD and the following surveillance may lead to the diagnosis of internal malignant neoplasms including early stage ones. Accurate imaging examinations in the following searching is essential in identifying the underlying neoplasms. Since whole-body 18-fluoro-2-deoxyglucose (F-18-FDG)-positron emission (PET)/computed tomography (CT) has been widely used in early diagnosis, staging of various malignant tumors, it may play a role for detection of underlying or occult malignant neoplasms in patients with PD. However, to date, only a few reports of FDG PET/CT findings of the associated neoplasms in PD patients have been cited in the literature. The present paper shows the cases of FDG-avid associated neoplasms in patients with PD in our 10-year experience in our institute, and reviews the well-known and/or relatively common PD and their associated neoplasms, and the previously reported cases of FDG-avid associated neoplasms in these patients.
Defining the “Positive Impact” of socio-technical systems for absolute sustainability: a literature review based on the identification of system design principles and management functions
Authors: Gebler Malte , Juraschek Max , Thiede Sebastian , Cerdas Felipe , Herrmann Christoph 
Published: June 2022

AbstractSocio-technical systems represent complex interactions of humans with ecological, social and economic systems. A system’s design and its operations determine whether its impact is “negative”, “neutral/zero” or “positive” over the system life cycle with regard to its contribution to sustainable development. But coping with exceeded planetary boundaries and social challenges requires more than “net-zero” approaches to achieve biosphere resilience and healthy societies. While negative and zero impacts are widely studied, the term “positive impact” has just recently gained importance to describe the outcome of design, planning, operational, organizational or engineering processes. Various case studies, reviews and conceptual proposals exist—mostly applied in a specific context—but a clear definition is not yet detectable. Based on a review of existing literature, this paper: (i) analyzes current perceptions of negative, zero and positive impacts of socio-technical systems on absolute sustainability, (ii) summarizes the current state of knowledge on positive impact concepts for sustainable development, (iii) identifies relevant socio-technical system design principles for positive impacts on biosphere, society and economy, (iv) derives management functions and organizational prerequisites within socio-technical systems to enable positive impacts, (v) proposes a guiding framework and a definition for “positive impact of socio-technical systems for absolute sustainability”, and (vi) discusses briefly potential applications and further research demand. This review intends to synthesize existing knowledge from an industrial and engineering design perspective, and delivers an overview on the subject from a global sustainability level to the operational level. The derived insights provide a basis for method development, system design processes and new business models.
Artificial Intelligence in Bariatric Surgery: Current Status and Future Perspectives
Authors: Bektaş Mustafa , Reiber Beata M. M. , Pereira Jaime Costa , Burchell George L. , van der Peet Donald L. 
Published: June 2022

Abstract
Background
Machine learning (ML) has been successful in several fields of healthcare, however the use of ML within bariatric surgery seems to be limited. In this systematic review, an overview of ML applications within bariatric surgery is provided.

Methods
The databases PubMed, EMBASE, Cochrane, and Web of Science were searched for articles describing ML in bariatric surgery. The Cochrane risk of bias tool and the PROBAST tool were used to evaluate the methodological quality of included studies.

Results
The majority of applied ML algorithms predicted postoperative complications and weight loss with accuracies up to 98%.

Conclusions
In conclusion, ML algorithms have shown promising capabilities in the prediction of surgical outcomes after bariatric surgery. Nevertheless, the clinical introduction of ML is dependent upon the external validation of ML.
Endoscopic Bariatric Treatment with Duodenal-Jejunal Bypass Liner Improves Non-invasive Markers of Non-alcoholic Steatohepatitis
Authors: Karlas Thomas , Petroff David , Feisthammel Jürgen , Beer Sebastian , Blüher Matthias , Schütz Tatjana , Lichtinghagen Ralf , Hoffmeister Albrecht , Wiegand Johannes 
Published: June 2022

Abstract
Purpose
People with obesity often develop non-alcoholic fatty liver disease (NAFLD) and are at high risk of progression to non-alcoholic steatohepatitis (NASH). Few therapies are effective other than bariatric surgery. We therefore analyzed data from duodenal-jejunal bypass liner (DJBL) patients regarding steatosis, fibrosis, and NASH.

Methods
Consecutive DJBL patients with type 2 diabetes underwent standardized assessments up to device removal at 48 weeks. These included aspartate and alanine transaminase (AST, ALT), controlled attenuation parameter (CAP, for steatosis), and liver stiffness measurement (LSM, for fibrosis). The NAFLD fibrosis score (NFS), fibrosis-4 score (FIB4), and enhanced liver fibrosis (ELF) test were also used to assess fibrosis and the Fibroscan-AST (FAST) score to assess NASH. Mixed models were used and missing data were accounted for with multiple imputation.

Results
Thirty-two patients (18 female, mean age 55.1, mean BMI 40.2 kg/m2) were included. After 48 weeks, the change compared to baseline with 95% CI was a factor 0.74 (0.65 to 0.84) for AST, 0.63 (0.53 to 0.75) for ALT, and a difference of − 0.21 (− 0.28 to − 0.13) for FAST, all with p < 0.001. Fibrosis based on LSM, NFS, and ELF did not change whereas FIB4 exhibited slight improvement. Eight DJBL were explanted early due to device-related complications and eight complications led to hospitalization.

Conclusions
One year of DJBL therapy is associated with relevant improvements in non-invasive markers of steatosis and NASH, but not fibrosis, and is accompanied by a substantial number of complications. Given the lack of alternatives, DJBL deserves further attention.

Graphical abstract
Ethnic Polarization and Human Development: The Conditional Effects of Minority Language Recognition
Authors: Csata Zsombor , Hlatky Roman , Liu Amy H. 
Published: June 2022

AbstractThe literature suggests ethnic diversity has a negative effect on development. Yet, we also know that government policies—e.g., recognizing multiple languages in minority-sizable areas—can attenuate these effects. In this paper, we ask: What are the socioeconomic implications of minority language recognition? We leverage a legal stipulation in Romania as a quasi-experiment: Minority languages are recognized as official in areas where the minority constitutes more than 20% of the population. We argue the recognition of minority languages builds social trust and facilitates efficiency in economic exchanges—mollifying the otherwise detrimental consequences of diversity. Using data at the municipality level, we find that in areas where only Romanian is recognized, ethnic diversity has a negative effect on development—a result consistent with the literature. This effect, however, is absent in areas where a minority language is recognized. The implications suggest that lowering the threshold for language recognition could promote even further development.
Assessing the Potency of the Novel Tocolytics 2-APB, Glycyl-H-1152, and HC-067047 in Pregnant Human Myometrium
Authors: Hossain Md Reduanul , Tolosa Jorge M. , Young Roger C. , Smith Roger , Paul Jonathan W. 
Published: June 2022

Abstract
The intracellular signaling pathways that regulate myometrial contractions can be targeted by drugs for tocolysis. The agents, 2-APB, glycyl-H-1152, and HC-067047, have been identified as inhibitors of uterine contractility and may have tocolytic potential. However, the contraction-blocking potency of these novel tocolytics was yet to be comprehensively assessed and compared to agents that have seen greater scrutiny, such as the phosphodiesterase inhibitors, aminophylline and rolipram, or the clinically used tocolytics, nifedipine and indomethacin. We determined the IC50 concentrations (inhibit 50% of baseline contractility) for 2-APB, glycyl-H-1152, HC-067047, aminophylline, rolipram, nifedipine, and indomethacin against spontaneous ex vivo contractions in pregnant human myometrium, and then compared their tocolytic potency. Myometrial strips obtained from term, not-in-labor women, were treated with cumulative concentrations of the contraction-blocking agents. Comprehensive dose–response curves were generated. The IC50 concentrations were 53 µM for 2-APB, 18.2 µM for glycyl-H-1152, 48 µM for HC-067047, 318.5 µM for aminophylline, 4.3 µM for rolipram, 10 nM for nifedipine, and 59.5 µM for indomethacin. A single treatment with each drug at the determined IC50 concentration was confirmed to reduce contraction performance (AUC) by approximately 50%. Of the three novel tocolytics examined, glycyl-H-1152 was the most potent inhibitor. However, of all the drugs examined, the overall order of contraction-blocking potency in decreasing order was nifedipine > rolipram > glycyl-H-1152 > HC-067047 > 2-APB > indomethacin > aminophylline. These data provide greater insight into the contraction-blocking properties of some novel tocolytics, with glycyl-H-1152, in particular, emerging as a potential novel tocolytic for preventing preterm birth.
Sexual Function and Problematic Use of Smartphones and Social Networking Sites
Authors: Fuzeiro Vanessa , Martins Catarina , Gonçalves Cátia , Santos Ana Rolos , Costa Rui Miguel 
Published: June 2022

ABSTRACT

Background
The use of social networking sites (SNS) sometimes acquires an addictive-like quality, often referred to as problematic use of SNS. This condition overlaps with problematic (addictive-like) use of smartphones, as the latter are commonly used for online social networking in addition to other activities that may gain addictive-like qualities. There is ample evidence that problematic use of smartphones and SNS is associated with poorer mental health, but research on associations with sexual function is scarce.

Aim
To examine if sexual difficulties are related to problematic use of SNS and smartphones.

Methods
Data from 4 studies conducted in Portugal between October 2019 and December 2021 (analyzed for the first time) were collapsed, resulting in 946 women and 235 men providing data on sexual function and problematic use of smartphones, and in 536 women and 194 men providing data on sexual function and problematic use of SNS. Female sexual function was assessed with the Female Sexual Function Index and the Female Sexual Distress Scale – Revised (FSDS-R). Male sexual function was assessed by the International Index of Erectile Function. Problematic smartphone use was measured by the Smartphone Addiction Scale – Short Version (SAS-SV). Problematic use of SNS was measured by the Internet Addiction Scale (IAT) specifically adapted to online social networking.

Outcomes
Participants rated their symptoms of problematic use of smartphones and SNS, as well as their sexual function.

Results
In women, problematic use of SNS correlated with lower sexual arousal (r = -0.22), difficulties lubricating (r = -0.13), difficulties having orgasms (r = -0.20), sexual dissatisfaction (r = -0.23), coital pain (r = -0.19), and greater sexual distress (r = 0.33). In men, problematic use of SNS correlated with lower erectile function (r = -0.26), lower desire (r = -0.17), intercourse dissatisfaction (r = -0.20), overall sexual dissatisfaction (r = -0.30), and more difficulties having orgasms (r = -0.20). For both sexes, correlations between sexual function and problematic smartphone use were in the same direction, but were generally weaker and, in most cases, become nonsignificant after controlling for problematic use of SNS.

Clinical Implications
Addictive-like use of SNS might be a risk factor for sexual difficulties.

Strengths & Limitations
This study is innovative and well-powered to uncover associations between poorer sexual function and addictive-like use of new technologies. The lack of representativeness of the sample warrants caution.

Conclusions
Problematic (addictive-like) use of SNS was associated with male and female sexual difficulties. This corroborates previous research.
Prophylaxis against spontaneous bacterial peritonitis: Too much or too little?
Authors: Dhanani Muhammad , Krishnamoorthy Aparna , Ciolino Jody D. , Gupta Kalpana , Strymish Judith M. 
Published: June 2022

Abstract
Prophylaxis against spontaneous bacterial peritonitis (SBP) is recommended for select patients with cirrhosis, but long-term antibiotic therapy has risks. We evaluated concordance with guideline recommendations in 179 veterans with cirrhosis; 55% received guideline-concordant management of SBP prophylaxis. Despite stable guideline recommendations since 2012, guideline adherence remains low.
Making the body politic through medicine: taste, health and identity in the Dutch Republic, 1636–1698
Authors: Hendriksen Marieke M.A. 
Published: June 2022

AbstractHow, where and by whom were bodies shaped, maintained and politicized through medicine, diet and taste in the seventeenth-century Low Countries? The medicinal use of foodstuffs, tastes and diets played an important role in the maintenance and restoration of health in the early modern period. Simultaneously, the metaphor of the body politic has been used widely in historical regimes, yet the focus tends to be on royalty or elite bodies, and on political literature and the medical metaphors used in relation to the body politic in such documents. In the seventeenth-century Low Countries, politically engaged medical men published popular medical literature aimed at the lower and middle classes in which they offered advice on diet and taste, which was aimed not only at maintaining and restoring health, but also at shaping emerging national tastes and identities. This chapter analyses six of the most popular medical and pharma-botanical works in the vernacular by seventeenth-century Dutch physicians. It shows that politics – and, by extension, ideas about the body politic – influenced popular medicine, and thus shaped the health, bodies and identities of the lower and middle classes through diet and taste.
Dimension estimates for iterated function systems and repellers. Part I
Authors: FENG DE-JUN , SIMON KÁROLY 
Published: June 2022

AbstractThis is the first paper in a two-part series containing some results on dimension estimates for
$C^1$
iterated function systems and repellers. In this part, we prove that the upper box-counting dimension of the attractor of any
$C^1$
iterated function system (IFS) on
${\Bbb R}^d$
is bounded above by its singularity dimension, and the upper packing dimension of any ergodic invariant measure associated with this IFS is bounded above by its Lyapunov dimension. Similar results are obtained for the repellers for
$C^1$
expanding maps on Riemannian manifolds.
Automatic taxonomic identification based on the Fossil Image Dataset (>415,000 images) and deep convolutional neural networks
Authors: Liu Xiaokang , Jiang Shouyi , Wu Rui , Shu Wenchao , Hou Jie , Sun Yongfang , Sun Jiarui , Chu Daoliang , Wu Yuyang , Song Haijun 
Published: June 2022

AbstractThe rapid and accurate taxonomic identification of fossils is of great significance in paleontology, biostratigraphy, and other fields. However, taxonomic identification is often labor-intensive and tedious, and the requisition of extensive prior knowledge about a taxonomic group also requires long-term training. Moreover, identification results are often inconsistent across researchers and communities. Accordingly, in this study, we used deep learning to support taxonomic identification. We used web crawlers to collect the Fossil Image Dataset (FID) via the Internet, obtaining 415,339 images belonging to 50 fossil clades. Then we trained three powerful convolutional neural networks on a high-performance workstation. The Inception-ResNet-v2 architecture achieved an average accuracy of 0.90 in the test dataset when transfer learning was applied. The clades of microfossils and vertebrate fossils exhibited the highest identification accuracies of 0.95 and 0.90, respectively. In contrast, clades of sponges, bryozoans, and trace fossils with various morphologies or with few samples in the dataset exhibited a performance below 0.80. Visual explanation methods further highlighted the discrepancies among different fossil clades and suggested similarities between the identifications made by machine classifiers and taxonomists. Collecting large paleontological datasets from various sources, such as the literature, digitization of dark data, citizen-science data, and public data from the Internet may further enhance deep learning methods and their adoption. Such developments will also possibly lead to image-based systematic taxonomy to be replaced by machine-aided classification in the future. Pioneering studies can include microfossils and some invertebrate fossils. To contribute to this development, we deployed our model on a server for public access at www.ai-fossil.com.