bluuebunny/crossref_metadata_2025_split huggingface dataset:
Kebijakan Pertanian dan Tanaman Pangan
Authors: Dewanta Awan Setya , Hamid Edy Suandi , Priyadi Unggul , Wijayanti Diana 
Published: April 2022

Kebijakan pertanian pangan belum mengalami perubahan sejak masa orde lama hingga sekarang. Kebijakan pertanian pangan masih diprioritaskan pada swasembada pangan (beras). Akibatnya adalah keswasembadaan tersebut memiliki arti politis karena dilakukan dalam rangka penghematan devisa, pengadaan pangan yang murah, dan mengendalikan inflasi. Kondisi ini memberikan dampak yang kurang menguntungkan bagi petani padi yang menganggap padi merupakan komoditi ekonomi sebagaimana komoditi pertanian lainnya.Untuk tetap mengembangkan pertanian pangan, kebijakan pertanian pangan tidak dapat terlepas dari kebijakan pertanian secara keseluruhan dan kebijakan makro-ekonomi. Kebijakan makro di negara-negara berkembang terbukti mengurangi net protection yang diperoleh dari kebijakan pertanian (kebijakan langsung), dan terjadi diskriminasi kebijakan terhadap pertanian.
Design and Finite Element Analysis of Lawn Mower Machine
Authors: Saferi Rozi , Yanto Asmara , Sucipto Joko 
Published: April 2022

Technological advances are now being found in everyday, one of them is an android smartphone. Android can be used to control motor speed without using cables with the help of microcontroller, motor driver and bluetooth module. In this study the autors designed and performed static analysis on the framework an android-based lawn mower using Autodesk Inventor. This grass cutting machine consists of several components, that is: framework, battery, microcontroller, motor driver, relay 5v, bluetooth module and others. The design result of an android-based lawn mower have a whole dimension with length = 298.89mm, width = 334.88mm and high = 241.02mm. After static analysis is carried out on the framework obtained results: Displacement minimum 0 mm and displacement maximum 0.0909735 mm, Safety factor minimum 1.93351 and safety factor maximum 15.
3D Lattice Boltzmann Method-Discrete-Element Method with Immersed Moving Boundary Scheme Numerical Modeling of Microparticles Migration Carried by a Fluid in Fracture
Authors: Wang Dongying , Wang Zhiming 
Published: April 2022

SummaryBased on the LBM-IMB-DEM (coupled lattice Boltzmann method-discrete-element method with immersed moving boundary scheme) model, the 3D microparticles’ migration carried by a fluid in fracture is numerically investigated both considering and not considering the van der Waals adhesive force. A boundary cells’ tracing method called the layer-by-layer tracing method both applicable to 2D and 3D situations for IMB with high efficiency and accuracy is proposed, and based on its searching results, the contacts in DEM could be detected straightforwardly with a finite amount of computation. In the layer-by-layer tracing method, a limited number of points, including some cell centers and nodes, near the particle boundary are determined whether they are covered by the particle, and then the other cells in one layer could be precisely classified. In the contact detecting process for DEM, based on the boundary cells tracing results in IMB, the cells that are covered by no less than two particles are the potential cells where there may be contacts. For wall boundaries with irregular shapes, the wall solid boundary (WSB) cells are converted to circumcircle (or circumscribed sphere in 3D situation), and then the solid particle-wall interactions could be replaced by the interactions between the solid particles and those circumcircles or circumscribed spheres. Two cases, including single-particle sedimentation in a viscous fluid, two-particle Drafting-Kissing-Tumbling (DKT) simulation for both nonadhesive and adhesive particles, are used to validate the LBM-IMB-DEM method. Besides, multiparticle sedimentation tests for different particle radiuses are conducted to present the advantages of the layer-by-layer tracing method. At last, nonadhesive and adhesive microparticles’ liberation, transport, and retention carried by a fluid in fracture with irregular shapes are simulated. The numerical results show that the adhesive force that plays a dominated role for microparticles has significant effects on the mechanics of solid particles migration. Under the influence of adhesive forces, the microparticles tend to form a stable agglomerate and migrate as a whole, which is different from the situation for nonadhesive particles where they are relatively independent and basically migrate by layer. Besides, even if the fluid velocity is much lower than the critical velocity evaluated through force or torque analysis on a single particle, when the total hydrodynamic forces exerted on the agglomerate overcome the total adhesive force between the wall and the lower layer of particles, the agglomerate can start to move and liberate from the wall.
Pilot study: Advanced hemodynamic monitoring after acute spinal cord injury. Keep the pressure up?
Authors: Drotleff Niklas , Jansen Oliver , Weckwerth Christina , Aach Mirko , Schildhauer T. A. , Waydhas Christian , Hamsen Uwe 
Published: April 2022

Abstract
Background: Although the use of vasopressors to maintain hemodynamic goals after acute spinal cord injury (SCI) is still recommended, evidence regarding the target values and possible risks of this practice is limited and data on hemodynamic parameters unaffected by catecholamines are rare. In this pilot study we show the hemodynamic profile of patients with acute SCI mainly unbiased by vasopressor use and other factors that influence the cardiovascular system. Methods: From March 2018 until March 2020, we conducted a prospective, single-center pilot study including 30 patients with acute SCI. Factors that could affect the cardiocirculatory system other than the SCI (sepsis, pre-existing heart disease or multiple trauma) led to the exclusion. A total of 386 measurements were performed using the PiCCO™ system. Results: Mean systemic vascular resistance index (SVRI, 1447.23±324.71 dyn*s*cm-5*m2), mean central venous pressure (CVP, 10.69±3.16) and mean global end-diastolic volume index (GEDVI, 801.79±158.95 ml/m2) deviated from the reference range while mean cardiac index (CI), mean stroke volume index (SI), mean arterial pressure (MAP), and mean heart rate (HR) were within the reference range as indicated in the literature. A mixed model analysis showed a significant negative relationship between norepinephrine treatment and MAP (83.97 vs 73,69 mmHg, p<0.001), SVRI (1463.40 vs 1332,14 dyn*s*cm-5*m2, p=0.001) and GEDVI (808.89 vs 759,39 ml/m2, p=0,001).Conclusion: These findings could lead to an adaptation of the target range for SVRI and MAP in patients with acute SCI and therefore reduce the use of vasopressors.
Activation of autophagy induces monocrotaline-induced pulmonary arterial hypertension by FOXM1-mediated FAK phosphorylation
Authors: Li Shaojun , Zhai Cui , Zhang Nana , Wang Jian , Cao Meng , Luan Jing , Liu Huan , zhang Qianqian , Zhu Yanting 
Published: April 2022

Abstract
Background: Activation of autophagy induces the proliferation of pulmonary artery smooth muscle cells (PASMCs) and vascular remodeling in rats, and therefore improves the development of pulmonary arterial hypertension (PAH). However, the possible mechanisms underlying autophagy in PAH have not been completely understood. The aims of this study are to address these issues. Method: Rat models of PAH were induced by intraperitoneally injection of monocrotaline (MCT). The right ventricle systolic pressure (RVSP), right ventricular hypertrophy index (RVHI), percentage of medial wall thickness (%MT), α-smooth muscle actin (α-SMA) staining and Ki67 staining were performed to evaluate the development of PAH. The protein levels of forkhead box M1 (FOXM1), focal adhesion kinase (FAK), phospho-FAK, and LC3B were determined by immunoblotting and immunohistochemistry. Results: FOXM1 protein level and the activation of FAK and autophagy were significantly increased in MCT-induced PAH rats. Pharmacological inhibition of FOXM1 and FAK suppressed MCT-induced autophagy activation, and reduced RVSP, RVHI and %MT, and ameliorated the proliferation of pulmonary arterial smooth muscle cells in MCT-induced PAH rats. Conclusion: FOXM1 induces the development of PAH by activation of FAK and consequent stimulating autophagy in MCT-treated rats.
Who’s Missing Out? Supply-demand mismatch analysis of urban ecosystem services in Singapore
Authors: Qiu Jiahui , Law Andrea , Richards Daniel R. , Gaw Leon Yan-Feng , Shaikh Shaikh Fairul Edros Bin , Jaung Wanggi , Carrasco Roman L 
Published: April 2022

Abstract
In the face of rapid urban densification, many cities have seen a decline in the extent of urban green spaces which are also the very landscape that provide a myriad of benefits for human well-being. This results in a mismatch between the ecosystem service supply from the urban natural landscape, and demand from the urban dwellers. While the mapping of ecosystem service supply and demand has been widely conducted for ecosystem service assessments, spatially explicit assessments of supply-demand balances and distributions are rarely explored in the urban context. Using Singapore as a case study, we mapped out the distribution of mismatches in six urban ecosystem services. In addition, we investigated the potential influence that a lived experience of ecosystem service supply-demand mismatch may have on residents’ perception towards the importance of ecosystem services. We found that the level of mismatch is predicted by proportion of unmanaged vegetation and distance to nature reserves. This is likely due to the distribution of unmanaged vegetation around the island state. Except for the noise abatement ecosystem service, we failed to find evidence of correlation between mismatch and Singaporeans’ perceived importance of ecosystem services, except in the case of noise abatement. This could potentially be influenced by the hyper-connectedness of Singapore’s landscape, allowing a locally unmet demand for ecosystem services to be fulfilled in a location with higher supply.
Facing Posttraumatic Stress Disorder in Brazil: A Survey of Therapist Practices
Authors: Cameoka Michelli Carrijo , Santi Luísa Jobim , Vermes Joana Singer , Rodrigues Carlos Manoel Lopes 
Published: April 2022

Abstract
Background
Brazil is a large, diverse, and heterogeneous country, and to date few studies have delved into the prevalence of PTSD within its population, or into how it has been treated. The aim of the present study was to report and discuss the results of a survey addressing the professional approaches adopted by Brazilian clinicians in treating PTSD.
Methods
Exploratory cross-sectional study targeted at therapists that had treated at least one PTSD case throughout their career. The data were collected from February 27th to May 8th, 2020, from a convenience sample (n = 208) of psychologists and physicians using an online form. The main subject matters were the psychotherapeutic treatments; diagnostic procedures; screening and assessment techniques; and difficulties and challenges.
Results
Less than half of the total sample (48.1%) declared they used instruments for screening and diagnosing. Cognitive behavioral therapy (CBT) was the most adhered to theoretical model (49%), more than 20 theoretical affiliations were mentioned, and 86 clinicians (41.3%) disclosed adherence to more than one theory, denoting an eclectic group. The individual case analysis, the scientific evidence, and treatment acceptance were ranked the most relevant criteria when selecting treatment. The most empirically supported trauma-focused psychotherapies were not among the more widely used. Lack of PTSD content in undergraduate courses (38.5%) was considered an important barrier to effective treatment.
Conclusions
The results may help mental health policymakers and providers devise strategies to bridge the gap between research and actual service delivery. The apparent short supply of training and supervision on evidence-based therapies poses an opportunity for colleges and other educational centers.
Examining the world’s countries in terms of outbreak, control, and vaccination against COVID-19
Authors: ebrahimi roghaye , Mirzaei Abasat 
Published: April 2022

Abstract
Objective: More than two years has passed from the emergence of COVID-19 challenging worldwide. countries adopted various approaches against this disease, such that some countries could control its outbreak and effects within a shorter time than other counties but many countries are still in an abnormal state. The statistical population used in this research consisted of the published associated with COVID-19 data of countries from WHO website. These data were analyzed through data mining and using R software. k-means algorithm was employed for clustering.
Results: The results indicated that the countries in the third cluster have undergone the worst level of damage in terms of variables related to outbreak, though they have had a better performance in terms of public vaccination compared to the countries of other clusters. The countries in the second cluster were found to be less afflicted in terms of transmission, mortality, and active cases, but regarding individual recovery, the number of tests taken, the variables related to public vaccination, the first cluster counties have shown a better performance. This study indicated that conterminous countries have a similar status against COVID-19. This can be due to similarities in political, cultural, social, economic, and other structures.
Personalized tumor antigen-pulsed dendritic cell therapy synergizes with simultaneous blockade of PD-1/TIM-3 to treat lung cancer
Authors: Hu Weidong , Chen Chen , Huang Jingyu , Wang Yujin , Wang Qingwen , Hu Liwen , Guo Zixin , Li Sheng 
Published: April 2022

Abstract
Background: Immunotherapy has become a promising innovation in human cancer treatment. However, only a minority of patients were benefited from immunotherapy, including PD-1/PD-L1 blockade, dendritic cell vaccine. Why these novel therapies failed and how to improve their therapeutic efficacy in cancer patients, particularly those with lung cancers, remain elusive. Methods: The function of dendritic cells (DCs) was analyzed by various ex vivo and in vivo assays. Bone marrow were exploited in vitro to drive DCs to load whole tumor antigens (thereafter named Ag-DC) for T cell priming in vitro and in vivo. In both syngeneic and endogenous lung tumor models, the therapeutic effect, underlying mechanisms and acquired resistance of Ag-DC therapy were examined. Finally, the safety and efficacy of combination therapy of Ag-DC and simultaneous blockade of PD-1 and TIM-3 were investigated.Results: The function of DCs is repressed with respect to phagocytosis of tumor cells and antigen-dependent T cell priming in lung tumor microenvironment. DCs derived from bone marrow in vitro are able to stimulate tumor antigen-specific T cell activation and subsequent killing of tumor cells. Local or systemic administration of whole tumor antigen-pulsed DCs (Ag-DCs) elicits potent T cell activation, enriched tumor-infiltrating lymphocytes, and increased memory T cells, contributing to fewer and smaller lung tumors. In addition, Ag-DC therapy induces expression of immune checkpoint molecules PD-1 and TIM-3 on T cells, which rationalizes the great synergistic efficacy of combination therapy of Ag-DC and simultaneous blockade of PD-1 and TIM-3.Conclusions: These findings suggest that bone marrow derived DCs in vitro loaded with whole tumor antigens can inhibit lung tumor initiation and progression by triggering strong T-cell antitumor activity, pulmonary recruitment, and tumor infiltration. Simultaneous blockade of PD-1 and TIM-3 synergizes with Ag-DC therapy in lung cancer treatment, representing a novel combination therapy for lung cancer.
Curcumin piperidone derivatives induce anti-proliferative and anti-migratory effects in LN-18 human glioblastoma cells
Authors: Chan Kok Meng , Razali Nur Syahirah Che , Lam Kok Wai , Rajab Nor Fadilah , Jamal A Rahman A , Kamaluddin Nurul Farahana 
Published: April 2022

Abstract
Curcumin has demonstrated potential cytotoxicity across various cell lines despite its poor bioavailability and rapid metabolism. Therefore, our group have synthesized curcuminoid analogues with piperidone derivatives, FLDP-5 and FLDP-8 to overcome these limitations. In this study, the analogues were assessed on human glioblastoma LN-18 cells in comparison to curcumin. Results from cytotoxicity assessment showed that FLDP-5 and FLDP-8 curcuminoid analogues caused death in LN-18 cells in a concentration-dependent manner after 24-h treatment with much lower IC50 values of 2.5 µM and 4 µM respectively, which were more potent compared to curcumin with IC50 of 31 µM. Moreover, a significant increase (p<0.05) in the level of superoxide anion and hydrogen peroxide upon 2-h and 6-h treatment confirmed the oxidative stress involvement in the cell death process induced by these analogues. These analogues also showed potent anti-migratory effects through inhibition of LN-18 cells’ migration and invasion. In addition, cell cycle analysis showed that these analogues are capable of inducing S-phase cell cycle arrest during the 24-h treatment, which explained the reduced proliferation indicated by MTT assay. In conclusion, these curcuminoid analogues exhibit potent anti-cancer effects with anti-proliferative and anti-migratory properties towards LN-18 cells as compared to curcumin.
Lycopene alleviates inflammatory explosion and oxidative stress in lipopolysaccharide-induced reprodu ctive system injury of male rats
Authors: Li Yu , Zhu Jinde , Liang Weining , Cai Hongcai , Shang Xuejun , Zhang Nan , Zhang Wei 
Published: April 2022

Abstract
Male reproductive system infection and inflammation negatively impacts male infertility through various mechanisms, while the factors precipitating these mechanisms remain obscure. Lipopolysaccharide (LPS) causes damage to male reproductive system by causing fatty acid metabolism disorder and induces inflammation. It is reported that Lycopene (LYC) has anti-inflammatory and antioxidant activities, perhaps being a treatment option for male infertility. The present study aimed to investigate the effects of LYC on LPS-induced testicular injury in male rats. The rats were treated with LPS (5 mg/kg i.p.).LYC was given at 5 mg/kg, i.g. for 4weeks, starting the 24 hours after treatment of LPS. The levels of interleukin1alpha(IL-1α), interleukin1beta(IL-1β), tumor necrosis factor alpha(TNF-α), monocyte chemotactic pretein1(MCP-1) and interleukin6(IL-6) in serum, testis and epididymis. Testicular and epididymal glutathione peroxidase(GSH-Px), superoxide dismutase(SOD), catalase (CAT) were measured. Testicular histopathological examination and epididymal sperm quality were further evaluated. LPS impaired testicular function by increasing the level of inflammatory cytokines and decreasing antioxidant capacity. LYC supplement reduces cytokines levels in serum, testis and epididymis and increases antioxidant activity. In conclusion, LYC can protect male infertility by extenuating male reproductive system inflammatory burst, and enhancing antioxidant defense, which is a new treatment strategy for male reproductive system infection and male infertility.
Are Happier People More Compliant? Global Evidence on Preventive Health Behaviours During Covid-19 Lockdowns
Authors: Krekel Christian , Swanke Sarah , De Neve Jan-Emmanuel , Fancourt Daisy 
Published: April 2022

Abstract
To combat the public health crisis of Covid-19, governments and public health officials have been asking individuals to substantially change their behaviours for prolonged periods of time. Are happier people more willing to comply with such measures? Using three independent, large-scale surveys covering about 119,000 adult respondents across 35 countries, including longitudinal data from the UK, we find that past and present life satisfaction predicts compliance with preventive health behaviours during Covid-19 lockdowns. The association is stronger for those with higher levels of life satisfaction. A loss in life satisfaction, on the contrary, predicts lower compliance. We explore risk-avoidance and pro-social motivations for this relationship, and find suggestive evidence that people who are older or have certain medical preconditions seem to be behave in line with risk-avoidance, whereas motivations of people who are less at risk of Covid-19 seem more mixed. Overall, our findings indicate that life satisfaction is important, both as a policy end in itself and for complying with new long-term preventive health measures.
Contactless crystallization method of protein by a magnetic force booster
Authors: MAKI Syou , HAGIWARA Masayuki 
Published: April 2022

Abstract
We developed a new type of compact magnetic force booster by which we succeeded in crystallizing proteins (hen egg white lysozyme) while making them levitate in a solution without contacting the container. This technique is noteworthy in the practical merit that we could control the growth of crystals from the initial stage of nucleation merely in a magnetic field of a few Tesla. The shape of the booster was designed in accordance with the dynamical stability against external forces acting on the crystals. Under a stable condition, the crystals condensed spherically, and formed a “shell shaped” crystallization with a hollow interior. Our magnetic force booster has the potential for innovation, especially in the field of protein crystal engineering.
Screening for anti-neoplastic enzymes producing halophilic bacterial extract and their antioxidant activity due to carotenoid synthesis
Authors: Rathakrishnan Deepalaxmi , Gopalan Arun Kumar 
Published: April 2022

Abstract
Out of 1127 halophilic bacteria, salt-loving microorganisms from different geographical locations in India isolated, twenty-eight strains were studied for antioxidant qualities for its usage in cancer medicines. The methanolic extracts were extracted and analyzed for anti-cancer effect through anti-neoplastic enzymes (L-asparaginase and L-glutaminase) screening, while antioxidant capabilities were investigated for fifteen isolates using both radical and non-radical assays.. The extracts also have enhanced radical scavenging ability against the stable 2,2'azinobis (3-ethylbenzothiazoline-6-sulfonic acid) disodium salt radical cation (86.34 ± 0.007 mM TE/g extract), nitric oxide (64.79 ± 0.004 µg/mL), phosphomolybdenum (1.69 ± 0.024 mg AAE/g extract), ferric reducing power (28.19 ± 0.012 mM Fe (II) E/mg) and showed better Ic50 values on 1,1-diphenyl- 2-picrylhydrazyl (5.48 mg/ml) assay. All of the studies has been done three times, and the results are significantly better than the standards utilized. Finally, four potent halophilic isolates from various antioxidant activities were chosen. These isolates could synthesize carotenoids that possessed anti-oxidant activities when grown in the halophilic medium was identified by UV/Visible spectra analysis. Secondary metabolite investigations using GC-MS study and LC-MS/MS analysis confirmed that isolated strains had the potential to produce compounds that might be used primarily as therapeutics. The enormous anti-oxidant potential of the strains Staphylococcus arlettae, Bacillus subtilis, B. tequilensis, and B. haynesii extracts could be used as a natural free radical scavenger to prevent oxidative-stress-related illnesses like cancer, neurodegeneration, as well as in the food safety markets in general.