bluuebunny/crossref_metadata_2025_split huggingface dataset:
The uptake and utility of genetic testing and genetic counseling for hypertrophic cardiomyopathy—A systematic review and meta‐analysis
Authors: Cirino Allison L. , Harris Stephanie L. , Murad Andrea M. , Hansen Brittany , Malinowski Jennifer , Natoli Jaime L. , Kelly Melissa A. , Christian Susan 
Published: July 2022

AbstractGenetic testing and genetic counseling are routinely indicated for patients with hypertrophic cardiomyopathy (HCM); however, the uptake and utility of these services is not entirely understood. This systematic review and meta‐analysis summarizes the uptake and utility of genetic counseling and genetic testing for patients with HCM and their at‐risk family members, as well as the impact of genetic counseling/testing on patient‐reported outcomes (PROs). A systematic search was performed through March 12, 2021. Meta‐analyses were performed whenever possible; other findings were qualitatively summarized. Forty‐eight studies met inclusion criteria (47 observational, 1 randomized). Uptake of genetic testing in probands was 57% (95% confidence interval [CI]: 40, 73). Uptake of cascade screening for at‐risk relatives were as follows: 61% for cascade genetic testing (95% CI: 45, 75), 58% for cardiac screening (e.g. echocardiography) (95% CI: 40, 73), and 69% for either/both approaches (95% CI: 43, 87). In addition, relatives of probands with a positive genetic test result were significantly more likely to undergo cascade screening compared to relatives of probands with a negative result (odds ratio = 3.17, 95% CI: 2.12, 4.76). Overall, uptake of genetic counseling in both probands and relatives ranged from 37% to 84%. Multiple studies found little difference in PROs between individuals receiving positive versus negative genetic test results; however, other studies found that individuals with positive genetic test results experienced worse psychological outcomes. Genetic testing may also inform life choices, particularly decisions related to reproduction and insurance. Genetic counseling was associated with high satisfaction, increased perceived personal control and empowerment, and decreased anxiety. Approximately half to three‐quarters of patients with HCM and their relatives undergo genetic testing or cascade screening. PROs after genetic testing varied and genetic counseling was associated with high satisfaction and improved PROs.
Opportunistic vegetation in quarry soil restoration from semiarid South East Spain: Pines and spontaneous species
Authors: Luna Lourdes , Lázaro Roberto , Miralles Isabel , Solé‐Benet Albert 
Published: July 2022

AbstractThe objective of our study was to undestand the effect of two organic amendments on three planted autochthonous species in two substrates mulched with pine chips 6 years after starting an experimental restoration in a quarry for cement production in semiarid SE Spain. But because this kind of mulch contained pine cones and pine seedlings appeared after the first year of the restoration, new objectives were added to the initial one: to check if organic amendments influenced pine growth among planted vegetation and if there were competition between planted and non‐planted species. Essential soil parameters, plant cover and diversity and pine growth were measured and statistically processed with correlation analyses, ANOVA and detrended correspondence analysis. Six years after restoration, organic amendments contributed significantly to explain the differences on the tested variables. The combined effects of the two substrates and the two organic amendments effectively enhanced soil properties recovery, but they also facilitated the establishment and entry of new species in addition to planted vegetation, driving a differential plant development. Planted vegetation cover and total plant cover from amended plots were double that of control plots. The number of pines, as well as their coverage, depended on the interaction between amendment type and substrate. Organic amendments favoured opportunistic species which, despite competing with those planted, helped to control soil erosion and enhanced pedogenesis. Pine chips used as mulch and derived pine seedlings, despite not entering the experimental design, might have some potential in the restoration of these particular degraded semiarid environments.
Fine‐Tuned Morphology Based on Two Well‐Miscible Polymer Donors Enables Higher Open‐Circuit Voltage and Enhanced Stability for Highly Efficient Ternary All‐Polymer Solar Cells
Authors: Liu Miao , Wu Jingnan , Guo Xia , Wang Yang , Yin Zhihong , Zhang Maojie 
Published: July 2022

AbstractDeveloping organic solar cells based on a ternary active layer is one of the most effective approaches to improve their photovoltaic performance. However, limited success has been achieved in all‐polymer solar cells (all‐PSCs). In this study, a ternary all‐PSC with improved efficiency and stability is realized by using J71 as the third component to adjust the host system of PBDB‐T:PG1. The deeper highest occupied molecular orbital (HOMO) energy level of J71 downshifts the mixed HOMO energy levels of donors. The two polymer donors (PDs) have good miscibility and present Förster resonance energy transfer. When blended with PG1, the optimized morphology is obtained, showing enhanced crystallinity but meanwhile slightly reduced phase separation with improved exciton dissociation and collection efficiency, suppressed charge recombination, and reduced energy loss (0.55 eV). Combining the benefits mentioned above, the ternary all‐PSC exhibits an excellent efficiency of 12.8% with simultaneously elevated open‐circuit voltage (0.96 V), short‐circuit current density (18.4 mA cm−2), and fill factor (72.2%). Moreover, the optimized ternary all‐PSC shows improved storage and thermal stability. This study demonstrates that the utilization of a ternary all‐polymer system based on two well‐miscible PDs is an effective strategy to enhance the photovoltaic performance and stability of all‐PSCs.
Properties and microstructure of copper/graphite composites with copper‐coated graphite fabricated by electroless plating and spark plasma sintering
Authors: Feng X. , Feng B. , Qin X. , Wang J. 
Published: July 2022

AbstractIn order to improve the interfacial bonding between copper and graphite, copper was coated on the graphite by electroless plating. Copper/graphite composites with copper‐coated graphite were fabricated by spark plasma sintering. The effects of copper‐coated graphite on the density, electrical conductivity, mechanical properties, friction and wear properties of copper/graphite composites were studied. The results show that: copper plating on the graphite surface can improve the wettability of graphite and copper, and the interface between them is well bonded. Compared with pure copper, the microstructure of the composites was significantly refined after adding copper‐coated graphite. The mechanical properties of the composites were significantly improved, with yield compressive strength and elastic modulus increasing by 220 % and 240 %, respectively. With the increase of copper‐coated graphite contents, the density and the conductivity of the composites gradually decreased. The friction coefficient and wear rate of the composites were significantly reduced. The friction and wear mechanisms of the composites are mainly oxidation wear, fatigue wear and adhesive wear.
Atomistic insight into the luminal allosteric regulation of vesicular glutamate transporter 2 by chloride and protons: An all‐atom molecular dynamics simulation study
Authors: Rostamipour Kiana , Talandashti Reza , Mehrnejad Faramarz 
Published: July 2022

AbstractVesicular glutamate transporters (VGLUTs) are essential components of synaptic transmission in the brain. Synaptic vesicles' luminal chloride and low pH regulate VGLUTs allosterically in a cooperative way. The luminal allosteric regulation of VGLUTs by chloride (Cl−) and proton (H+) is possible through the collective work of luminal Cl− and H+ binding site residues. However, precise atomistic details about the luminal Cl− binding to the luminal Cl− binding site and the role of allosteric activation by H+ in VGLUTs are unknown. Using all‐atom molecular dynamics simulations, this study demonstrates the critical role of Cl− binding site residues, details about Cl− binding to the luminal Cl− binding site, and the role of allosteric regulation of VGLUT2 by H+ at an atomistic level. By point mutations, we found out that Arginine (R184), Histidine (H128), and Glutamate (E191) are critical residues in the allosteric regulation of VGLUT2, R184 is the luminal Cl− binding site residue, and H128 and R88 support Cl− binding to R184. Furthermore, we found out that the protonation of H128 and E191 is important in Cl− binding to the luminal Cl− binding site. Furthermore, we investigated the essential interactions between Cl− and H+ binding site residues. Our results can give atomistic evidence for a previous experimental hypothesis about the VGLUTs luminal allosteric regulation by H+ and Cl−.
Approaches to Obtaining Fluorenes: An Alternate Perspective
Authors: Das Anusha S. , Nair Ajil R. , Sreekumar Anjana , Sivan Akhil 
Published: July 2022

AbstractFluorene is a well conjugated, planar, polycyclic aromatic organic compound that was first noticed, isolated, and purified by a French chemist, Marcellin Berthelot, in 1867. Since then, plenty of scientific investigators has spent years and decades understanding more about fluorene and its derivatives because of its high scope of applications in polymers, electronic devices, sensors, and photochromic materials. By considering the significance and novelty of the title molecule and the need for a concise assembly of its various synthetic methodologies, we tried to incorporate all the significant and recent developments and modifications regarding the synthesis of fluorenes. Here we portrayed various synthetic strategies to get different classes of fluorenes, including 9‐substituted fluorenes, spirofluorene‐based compounds, fluorenes with ring substitution, and fluorene‐based oligomers and polymers. The synthetic approaches for designing fluorene derivatives that are of high utility as well as environment friendly have been briefed in this review.
Syntheses of Mersicarpine, a Monoterpenoid Indole Alkaloid with an Atypical Tetracyclic Structure
Authors: Xiao Jie , Zhou Guang‐Hua , Ji Cong‐Bin 
Published: July 2022

AbstractThe focus review discusses the synthesis of an important member of the monoterpene indole alkaloid family, mersicarpine. Biosynthetically, mersicarpine, isolated from the Kopsia fruticosa and Kopsia arborea, is proposed to share the same biogenetic pathway as melodinine E and leuconolam, and has a fused tetracyclic [6.5.6.7] ring system characterized by an unusual tetrahydro‐2H‐azepine ring and a hemiaminal motif. As a consequence, this intriguing structural feature has attracted considerable attention from synthetic chemists. The review focuses on the synthesis of mersicarpine from its first synthesis to the most recent one, ranging from 2008–2022.
Early Warning of Coal Spontaneous Combustion: A Study of CO Response Mechanism Based on PANI/Ti3AlC2 Composite Gas Sensing Film**
Authors: Wang Xu‐Wei , Hu Xiang‐Ming , Liang Yun‐Tao , Wu Ming‐Yue , Xue Di , Yu Xiao‐Xiao , Liu Jin‐Di , Dong Hao , Luo Chong‐Yang , Yang Zhen‐Yu 
Published: July 2022

AbstractFire accidents caused by coal spontaneous combustion seriously affect the production safety of coal mines. Carbon monoxide (CO) is an important gas indicator used for monitoring and early warning detection of coal spontaneous combustion. Therefore, the development of CO sensors with low cost, low power consumption, and environmental protection is highly desirable. This can be achieved through deep optimization of semiconductor CO sensors as alternatives to infrared detection and electrochemical sensors. In this paper, Ti3AlC2 (MXenes)/polyaniline (PANI) composite were studied as semiconductor CO sensors. The optimal added amount of Ti3AlC2 was determined by testing at gas concentrations of 100 ppm and 150 ppm CO. The morphology, structure, and chemical characteristics of each composite were analyzed by field emission transmission electron microscopy (SEM‐EDS), Fourier infrared spectrometry, UV‐visible near infrared spectrophotometer, X‐ray photoelectron spectroscopy (XPS), and thermogravimetric techniques. Compared to pure PANI material, the SEM‐EDS experimental results showed Ti3AlC2 with an increased number of PANI flake structures, generating more CO gas adsorption sites. The XPS results showed Ti3AlC2 was able of improving the protonation and oxidation degree of PANI, thereby improving its gas sensing performance. Accordingly, a sensing mechanism model was proposed, revealing the excellent sensing performance originating from the gas sensing enhancement effect of heterojunction. In sum, this study provided a scientific basis for the design and development of CO sensors with low cost, low power consumption, and future environmental protection.
Novel Ortho‐Linkage Donor‐Acceptor Type Host Materials for Efficiently Red Phosphorescence Organic Light‐Emitting Diodes
Authors: Yang Yong‐Jian , Wei Jia‐Jia , Xiang‐YangLiu  , Li Runlai , Zhang Zhen‐Ming 
Published: July 2022

AbstractHigh performance device is the key issue for organic light‐emitting diodes (OLEDs) industrialization. In this instance, efficient hosts, emitters, as well as other functional layer materials are essential for the realization of high‐performance OLEDs. Herein, we develop a series of D−A type host materials, TPATRZ, CzTRZ, and POXTRZ with ortho‐linking strategy. The ortho‐linkage makes TPATRZ, CzTRZ, and POXTRZ highly twisted conformations, which reducing the degree of intramolecular conjugation and maintain high triplet energies of these materials. The red phosphorescence organic light emitting diodes by using Ir(piq)2(acac) as dopant, TPATRZ, CzTRZ, and POXTRZ as host materials achieved relative high device performance with over 20 % external quantum efficiency and flat efficiency roll‐off. The EQEs of the champion devices remain above 22 % at the practical luminance (500 and 1000 cd m−2). The device hosted by POXTRZ achieved the highest external quantum efficiency of 24.0 %, as well as smallest efficiency roll‐off of 6.3 % at 1000 cd m−2. These results further extend the possibilities of ortho‐linkage D−A type host materials and make them have a promising application in OLEDs.
An Efficient Ni(II) Laurate Promoted Heterocyclization of Symmetrical Thioureas with Maleic Anhydride and Mechanistic Approach toward Higher Substituted Thiazolidine‐4‐one‐5‐acetic Acids
Authors: Yıldırım Ayhan , Öztürk Serkan 
Published: July 2022

AbstractFor the first time, readily available Ni(II) laurate catalyzed thia‐Michael addition of symmetrical N,N‐disubstituted thioureas to maleic anhydride and subsequent cyclization in toluene afforded novel thiazolidine‐4‐one‐5‐acetic acids with good yields in a short reaction time. The efficiency and low cost of the renewable, eco‐friendly laurate based homogenous Lewis acid catalyst and the fact that cyclization proceeds in a much shorter time means that this synthetic method is interesting from a green chemistry point of view. The catalyst can be reused for many times without any significant loss of activity.
Engineering Bioactive M2 Macrophage‐Polarized, Anti‐inflammatory, miRNA‐Based Liposomes for Functional Muscle Repair: From Exosomal Mechanisms to Biomaterials
Authors: Luo Zhiwen , Qi Beijie , Sun Yaying , Chen Yisheng , Lin Jinrong , Qin Haocheng , Wang Ning , Shi Runjie , Shang Xiliang , Chen Shiyi , Chen Jiwu 
Published: July 2022

AbstractSevere inflammation and myogenic differentiation disorder are the major obstacles to skeletal muscle healing after injury. MicroRNAs (miRNAs) play an important role as regulatory molecules during the process of muscle healing, but the detailed mechanism of miRNA‐mediated intercellular communication between myoblasts and macrophages remains unclear. Here, it is reported that myoblasts secrete miRNAs‐enriched exosomes in the inflammatory environment, through which miR‐224 is transferred into macrophages to inhibit M2 polarization. Further data demonstrate that WNT‐9a may be a direct target of miR‐224 for macrophage polarization. In turn, the secretome of M1 macrophages impairs myogenic differentiation and promotes proliferation. Single‐cell integration analysis suggests that the elevation of exosome‐derived miR‐224 is caused by the activation of the key factor E2F1 in myoblasts and demonstrates the RB/E2F1/miR‐224/WNT‐9a axis. In vivo results show that treatment with antagomir‐224 or liposomes containing miR‐224 inhibitors suppresses fibrosis and improves muscle recovery. These findings indicate the importance of the crosstalk between myoblasts and macrophages via miRNA‐containing exosomes in the regulation of macrophage polarization and myogenic differentiation/proliferation during muscle healing. This study provides a strategy for treating muscle injury through designing an M2 polarization‐enabling anti‐inflammatory and miRNA‐based bioactive material.
Private credit in dual banking countries: Does bank ownership type matter?
Authors: Noordin Nazrul Hazizi , Mohd Rasid Mohamed Eskandar Shah , Ibrahim Mansor H. 
Published: July 2022

AbstractThis study investigates how the effects of government and foreign bank ownership on private credit vary in the cases of Islamic and conventional banks using data extended from Claessens and van Horen (2014) of 29 dual banking countries from 1995 to 2017. In support of the political view of financial development, we find that the presence of state‐owned Islamic banks seem to be slightly less harmful to private credit flows than their conventional peers, particularly in the period after the global financial crisis. We also document evidence showing that countries with a larger foreign Islamic bank presence tend to have deeper credit markets postcrisis. However, such advantages may often be outweighed by the costs associated with increased penetration by foreign conventional banks.
Contributions to expenditure in endoscopic stone management: a costly process
Authors: Mondschein Romy , Bolton Damien , Tan Sarah , Vu Minh Hang , McCahy Philip 
Published: July 2022

AbstractNo comprehensive cost estimates exist for performing ureteropyeloscopy (URS), which is increasingly utilised as a treatment of upper tract urolithiasis in Australia. To estimate expenditure associated with URS in an Australian public hospital setting and determine factors contributing to increased cost. Patients who underwent flexible URS for urolithiasis over a 2-year period at a Victorian public health site were included. Data describing demographics, stone factors, disposable equipment and admission length were retrospectively collected. Procedures were performed using reusable flexible scopes. Previously validated costing models for cystoscopic stent extraction, theatre and recovery per hour and ward admission were used to attach cost to individual episodes. The cost of emergency stent insertion was beyond the scope of this study. 222 patients underwent URS; the combined total number of procedures was 539, comprising 202 stent extractions and 115 stent insertions in addition to 222 URS. Mean procedural cost was $2885 (range $1380–$4900). Mean episode cost excluding emergency stent insertion was $3510 (range $1555–$7140). A combination of flexible scopes, operative time and disposable equipment accounted for nearly 90% of the total procedural cost. Significant cost is associated with URS for treatment of renal and ureteric stones. A large burden of the cost is time in theatre, equipment and the need for multiple associated procedures per episode. Utilising other available treatments such as extracorporeal shockwave therapy (SWL) where appropriate may reduce the financial burden of URS and associated procedures.
Is the performance at the implicit association test sensitive to feedback presentation? A Rasch-based analysis
Authors: Epifania Ottavia M. , Robusto Egidio , Anselmi Pasquale 
Published: July 2022

AbstractThe Implicit Association Test (IAT) is commonly used for the indirect assessment of psychological constructs. While the features of the IAT that might influence the performance of the respondents have been extensively investigated, the effect of informing the respondents about the correctness of their responses (i.e., feedback presentation) has been poorly addressed so far. The study addresses this issue by presenting an across-domain (implicit prejudice and food preference) Rasch-based analysis of IAT data obtained with and without feedback presentation. Results showed that speed was influenced by the interaction between feedback presentation and associative condition, whereas accuracy was influenced by the associative condition. This result varied across-domain. Results suggested that IATs administered with feedback presentation provide more accurate information on the construct of interest.
Effects of an amino acid buffered hypochlorite solution as an adjunctive to air-powder abrasion in open-flap surface decontamination of implants failed for peri-implantitis: an ex vivo randomized clinical trial
Authors: La Monaca Gerardo , Pranno Nicola , Mengoni Fabio , Puggioni Gianluca , Polimeni Antonella , Annibali Susanna , Cristalli Maria Paola 
Published: July 2022

Abstract
Objectives
To evaluate ex vivo the efficacy of an amino acid buffered hypochlorite solution supplemented to surface debridement with air-powder abrasion in removing bacterial biofilm following open-flap decontamination of implants failed due to peri-implantitis.

Materials and methods
This study was an ex vivo, single-blind, randomized, intra-subject investigation. Study population consisted of 20 subjects with at least three implants failed for peri-implantitis (in function for > 12 months and progressive bone loss exceeding 50%) to be explanted. For each patient, implants were randomly assigned to surface decontamination with sodium bicarbonate air-powder abrasion (test-group 1) or sodium bicarbonate air-powder abrasion supplemented by amino acid buffered hypochlorite solution (test-group 2) or untreated control group. Following open-flap surgery, untreated implants (control group) were explanted. Afterwards, test implants were decontaminated according to allocation and explanted. Microbiological analysis was expressed in colony-forming units (CFU/ml).

Results
A statistically significant difference in the concentrations of CFU/ml was found between implants of test-group 1 (63,018.18 ± 228,599.36) (p = 0.007) and implants of test-group 2 (260.00 ± 375.80) (p < 0.001) compared to untreated implants (control group) (86,846.15 ± 266,689.44). The concentration of CFU/ml on implant surfaces was lower in test-group 2 than in test-group 1, with a statistically significant difference (p < 0.001).

Conclusion
The additional application of amino acid buffered hypochlorite solution seemed to improve the effectiveness of implant surface decontamination with air-powder abrasion following open-flap surgery.
Clinical relevance.
Lacking evidence on the most effective method for biofilm removal from contaminated implant surfaces, the present experimental study provides further information for clinicians and researchers.
Optimization of the structural complexity of artificial neural network for hardware-driven neuromorphic computing application
Authors: Udaya Mohanan Kannan , Cho Seongjae , Park Byung-Gook 
Published: July 2022

AbstractThis work focuses on the optimization of the structural complexity of a single-layer feedforward neural network (SLFN) for neuromorphic hardware implementation. The singular value decomposition (SVD) method is used for the determination of the effective number of neurons in the hidden layer for Modified National Institute of Standards and Technology (MNIST) dataset classification. The proposed method is also verified on a SLFN using weights derived from a synaptic transistor device. The effectiveness of this methodology in estimating the reduced number of neurons in the hidden layer makes this method highly useful in optimizing complex neural network architectures for their hardware realization.