bluuebunny/crossref_metadata_2025_split huggingface dataset:
ASPEK EKONOMI USAHA BUDIDAYA RUMPUT LAUT EUCHEUMA COTONII DI DESA LIYA TOGO KECAMATAN WANGI-WANGI SELATAN KABUPATEN WAKATOBI
Authors: Oliviati Wa Ode Oliviati , La Ola La Onu , Piliana Wa Ode 
Published: November 2022

Tujuan dari penelitian ini adalah untuk mengkaji besaran biaya dan penerimaan dan mengkaji besaran keuntungan usaha bisnis para nelayan setiap kali produksi. Penelitian ini di Laksanakan pada bulan Oktober sampai bulan November 2019. Penelitian ini di laksanakan pada bulan Oktober sampai bulan November 2019 di Desa Liya Togo Kecamatan Wangi-Wangi Selatan Kabupaten Wakatobi. Metode dalam penelitian ini mengunakan Meode kuantitatif dengan menghitung mengunakan rumus TC = TVC + TVC dan menghitung keuntungan usaha nelayan budidaya Rumput Laut mengunakan rumus (π) =TR-TC. Analisis data yang di gunakan dalam penelitian ini adalah analisis R/C rasio dan keuntungan. Hasil penelitian ini menunjukan rata-rata (TC) sebesar Rp 4.814.457.Rata-rata pendapatan (TR) sebesar Rp6.048.000. dan rata-rata Keuntungan (π) sebesar Rp1.233.543.Hasil penelitian ini menunjukan bahwa usaha budidya rumput laut layak untuk di kembangkan di lihat dari aspek finansial. Kata kunci :Kelayakan finansial, Budidaya Rumput Laut
PEMBINAAN NARAPIDANA DALAM PERSPEKTIF STRUKTURAL FUNGSIONAL DI RUMAH TAHANAN NEGARA KELAS IIB UNAAHA
Authors: Sumardin Oschar , Safar Misran , Bauto La Ode Monto 
Published: November 2022

Tujuan dalam penelitian ini adalah: 1) Untuk mendeskripsikan dan menganalisis proses pembinaan narapidana dalam perspektif struktural fungsional di Rumah Tahanan Negara Kelas IIB Unaaha; 2) Untuk mendeskripsikan dan menganalisis kendala pada pembinaan narapidana dalam perspektif struktural fungsional di Rumah Tahanan Negara Kelas IIB Unaaha; 3) Untuk mendeskripsikan dan menganalisis solusi dari kendala pada pembinaan narapidana dalam perspektif struktural fungsional di Rumah Tahanan Negara Kelas IIB Unaaha. Hasil penelitian menunjukkan bahwa: 1) Proses pembinaan narapidana dalam Perspektif Struktur Fungsional di Rumah Tahanan Negara Kelas IIB Unaaha, adalah terdiri dari: Pembinaan berdasarkan situasi, pembinaan perorangan, pembinaan secara kelompok pembinaan kemandirian, pembinaan kepribadian, 2) Kendala pada pembinaan narapidana yaitu: a. faktor pembinaan diantaranya kurangnya mentor dalam bidang psikologi, keagamaan, pertukangan, kerajinan tangan, perkebunan, serta kurangnya anggaran dan hasil produksi kurang laku menjadi penghambat dalam proses pembinaan; b. Kurangnya motivasi pada narapidana; c. Faktor sarana atau fasilitas; 3) Solusi dari kendala pada pembinaan yaitu: a. Kualitas petugas pemasyarakatan dalam pembinaan terdiri dari petugas sebagai pembimbing dan pendidik, pekerja sosial, wali atau orang tua, pemelihara keamanan, dan komunikator dengan masyarakat; b. Peran masyarakat dalam menunjang pembinaan dengan berinteraksi langsung dengan masyarakat dengan melakukan penyuluhan seperti pemasangan baliho, penempelan poster, dan pemanfaatan media masa seperti iklan; c. Adanya pelatihan keterampilan yang dilakukan oleh istansi pemerintahan seperti Depak, BLK, Dinkes, BNN, dan Pemberdayaan Perempuan.Kata kunci: Pembinaan Narapidana; Perspektif Struktural Fungsional; Rutan
Progression of functional and structural glaucomatous damage in relation to diurnal and nocturnal dips in mean arterial pressure
Authors: Melgarejo Jesus D. , Van Eijgen Jan , Wei Dongmei , Maestre Gladys E. , Al-Aswad Lama A. , Liao Chia-Te , Mena Luis J. , Vanassche Thomas , Janssens Stefan , Verhamme Peter , Van Keer Karel , Stalmans Ingeborg , Zhang Zhen-Yu 
Published: November 2022

BackgroundSystemic hypoperfusion plays a pivotal role in the pathogenesis of primary open-angle glaucoma (POAG). Extreme dips in mean arterial pressure (MAP) due to high 24-h variability are associated with POAG, however, whether this is driven by diurnal or nocturnal dips remains undocumented. We aimed this study to investigate the association of POAG damage with variability and dips in the diurnal and nocturnal MAP.MethodsWe conducted a retrospective longitudinal study that included 110 POAG patients who underwent 24-h ambulatory blood pressure monitoring. Our outcomes included (i) functional [visual field defects expressed as mean deviation (MD)] and (ii) structural (optic disc cupping obtained from cup-to-disc ratio) glaucoma damage. MAP variability independent of the mean (VIMmap) was computed for diurnal and nocturnal MAP. Dips were the five diurnal and three nocturnal lowest drops in MAP. We also calculated the night-to-day ratio. We applied mixed models to evaluate the progression of visual field defects and optic disc cupping in relation to diurnal and nocturnal MAP measures.ResultsThe mean age was 64.0 y (53% women). The median follow-up was 9 years. In adjusted mixed models, functional progression of glaucoma damage was associated with VIMmap (−2.57 dB change in MD per every 3 mmHg increase in VIMmap; P &lt; 0.001) and diurnal MAP dips (changes in the MD ranged from −2.56 to −3.19 dB; P &lt; 0.001). Every 5 mmHg decrease in the nocturnal MAP level was associated with −1.14 dB changes in MD [95% confidence interval (CI), −1.90 to −0.40] and 0.01 larger optic disc cupping (95% CI, 0.01–0.02). Lower night-to-day ratio was also related to both outcomes (P ≤ 0.012). Functional glaucoma damage worsened if nocturnal hypotension was combined with high variability or extreme dips in the diurnal MAP (P ≤ 0.022).ConclusionProgression of glaucoma damage in POAG associates with high variability and extreme dips in the diurnal MAP. Structural glaucoma damage seems more vulnerable to nocturnal hypotension. Ambulatory blood pressure monitoring allows the assessment of sporadic diurnal and persistent nocturnal hypotension episodes. These phenotypes might offer an opportunity to improve the risk-stratification of open-angle glaucoma (OAG).
Megameter propagation and correlation of T-waves from Kermadec Trench and Islands
Authors: Oliveira Tiago C. A. , Nielsen Peter , Lin Ying-Tsong , Kushida Noriyuki , Jesus Sérgio M. 
Published: November 2022

On 18 June 2020 and 4 March 2021, very energetic low-frequency underwater T-wave signals (2 to 25 Hz) were recorded at the Comprehensive Nuclear-Test-Ban Treaty (CTBT) International Monitoring System (IMS) hydrophone stations in the Pacific Ocean (Stations HA11 and HA03) and the South Atlantic Ocean (Station HA10). This work investigates the long-range (megameters) propagation of these T-waves. Their sources were three powerful submarine earthquakes in the Kermadec Trench and Islands, located at approximately 6000, 8800, and 15100 km from Stations HA11, HA03, and HA10, respectively. Arrival time and back azimuth of the recorded T-waves were estimated using the Progressive Multi-Channel Correlation algorithm installed on the CTBT Organization (CTBTO) virtual Data Exploitation Centre (vDEC). Different arrivals within the duration of the earthquake signals were identified, and their correlations were also analyzed. The data analysis at HA03 and HA10 revealed intriguing T-wave propagation paths reflecting, refracting, or even transmitting through continents, as well as T-wave excitation along a chain of seamounts. The analysis also showed much higher transmission loss (TL) in the propagation paths to HA11 than to HA03 and HA10. Moreover, strong discrepancies between expected and measured back azimuths were observed for HA11, and a three-dimensional (3D) parabolic equation model was utilized to identify the cause of these differences. Numerical results revealed the importance of 3D effects induced by the Kermadec Ridge, Fiji archipelago, and Marshall Islands on T-wave propagation to HA11. This analysis can guide future improvements in underwater event localization using the CTBT-IMS hydroacoustic sensor network.
The presence of diabetic retinopathy closely associated with the progression of non-alcoholic fatty liver disease: A meta-analysis of observational studies
Authors: Zhang Guo-heng , Yuan Tian-hao , Yue Zhen-sheng , Wang Lin , Dou Guo-Rui 
Published: November 2022

Background and Objective: Although growing evidence indicates that non-alcoholic fatty liver disease is related to diabetic retinopathy (DR), research results significantly vary. Therefore, we conducted a meta-analysis to assess the association between the progression of non-alcoholic fatty liver disease and the onset of DR.Methods: PubMed, Embase, and Cochrane databases were searched until 7 November 2021. Combined odds ratios (ORs) and 95% confidence intervals (CIs) were used to assess the association.Results: We identified 18 studies involving 12,757 patients. The pooled effect assessment showed that liver fibrosis was positively correlated with DR (OR = 1.69, 95%CI 1.30–2.20; p &lt; 0.0001); non-alcoholic fatty liver disease was not associated with the risk of DR (OR = 1.15, 95%CI 0.75-1.76; p = 0.51); non-alcoholic fatty liver disease was positively correlated with DR in patients with type 1 diabetes (OR = 2.96, 95%CI 1.48–5.94; p = 0.002). In patients with type 2 diabetes, there was no association between non-alcoholic fatty liver disease and DR (OR = 0.92, 95%CI 0.59–1.43; p = 0.70). Subgroup analysis showed no correlation in both Asian and Caucasian races.Conclusion: There is a significant correlation between liver fibrosis and DR. This suggests that the ocular examination of DR could be helpful in predicting whether patients with non-alcoholic fatty liver disease would progress to liver fibrosis.
Association between electroconvulsive therapy and depressive disorder from 2012 to 2021: Bibliometric analysis and global trends
Authors: Cai Haipeng , Du Ruonan , Yang Kebing , Li Wei , Wang Zhiren 
Published: November 2022

BackgroundDepressive disorder is a chronic mental illness that is vulnerable to relapse, imposes a huge economic burden on society and patients, and is a major global public health problem. Depressive disorders are characterized by depressed mood, decreased energy and interest, and suicidal ideation and behavior in severe cases. They can be treated through pharmacotherapy and psychotherapy or physical treatments such as electroconvulsive therapy (ECT). In patients with suicidal ideation, behavior, or refractory depressive disorder ECT has a faster onset of action and better efficacy than pharmacotherapy. This study used bibliometric and visual analyses to map the current state of global research on ECT for depressive disorder and to predict future research trends in this area.Materials and methodsA literature search was performed for studies on ECT and depressive disorder in the Web of Science Core Collection (WoSCC) database. All studies considered for this paper were published between 2012 and 2021. Bibliometric and co-occurrence analyses were performed using the CiteSpace software.ResultsIn total, 2,184 publications were retrieved. The number of publications on ECT and depressive disorder have been increasing since 2012, with China being a emerging hub with a growing influence in the field. Zafiris J. Daskalakis is the top author in terms of number of publications, and The Journal of ECT is not only the most published journal but also the most co-cited journal in the field. Co-occurrence analysis showed that electroconvulsive therapy, treatment-resistant depression, bipolar disorder, hippocampus, efficacy, and electrode placement are current research hotspots. Molecular biomarkers, neuroimaging predictors, and late-life depression will become research hotspots in the future.ConclusionOur analysis made it possible to observe an important growth of the field since 2012, to identify key scientific actors in this growth and to predict hot topics for future research.
The prognostic role of sex and hemoglobin levels in patients with oral tongue squamous cell carcinoma
Authors: Tagliabue Marta , D’Ecclesiis Oriana , De Berardinis Rita , Gaeta Aurora , Martinoli Chiara , Piana Andrea Fausto , Maffini Fausto , Gandini Sara , Ansarin Mohssen , Chiocca Susanna 
Published: November 2022

BackgroundWomen and men differ genetically, biologically (sex) and by social construct (gender), possibly impacting on prognostic factors in predicting cancer survival. Hemoglobin levels and immune system activation are players acting in this scenario which could play a role in partly determining prognosis between patients of different sex/gender (S/G). Here, we investigate these factors in patients affected by tongue squamous cell carcinoma.MethodsThis is an observational retrospective cohort study. We collected tongue cancer patients’ clinical data, including hemoglobin levels and neutrophil lymphocyte ratio (NLR). Overall survival (OS) and disease-free survival (DFS) were compared between women and men considering confounding and prognostic factors in multivariate Cox proportional hazard models. Stratified analyses were also conducted by sex and tumor stage.Result576 patients, 39.9% women and 60.1% men, were found eligible for the analysis. Men were more often smokers (p&lt;0.001), alcohol consumers (p&lt;0.001), overweight or obese (p&lt;0.001) and undergoing radiotherapy (p=0.002). In multivariate models for stage I-II, men showed half risk of death and relapse compared to women (HR=0.44; 95%CI 0.24-0.81, p=0.009; HR=0.55; 95%CI 0.34-0.87, p=0.01, for OS and DFS respectively). Moreover, low hemoglobin levels appeared to be an independent prognostic factor for women but not for men in terms of both OS and DFS. Specifically, women with low hemoglobin levels showed a worse tumor outcome (HR=2.66; 95%CI 1.50-4.70; HR=2.09; 95%CI 1.24-3.53, for OS and DFS respectively). Low hemoglobin levels appeared to be a poor OS prognostic factor for women at stage I-II (p&lt;0.004) but not for men (p=0.10). Women with advanced stage tumors, NLR&gt;2.37, who did not performed Radiotherapy and with depth of invasion (DOI)&gt; 10 were associated with a significant increase in relapse and death (all p&lt;0.05).ConclusionIn our cohort of patients with oral tongue squamous cell carcinoma, men present better OS and DFS than women with early stages tumors. Low hemoglobin level was an independent prognostic factor for women, especially at early-stage tumors. For advanced stages (III-IV), sex is not a significant factor related to patients’ prognosis.
The full management from first-line to third-line treatments in patients with Her-2–negative advanced gastric cancer
Authors: Chang Chunxiao , Pei Yanqing , Xu Jun , Zhang Wenyu , Zhang Jianbo , Shi Shengbin 
Published: November 2022

BackgroundThe aim of this study was to retrospectively evaluate the efficacy of full management from first-line to third-line treatments in patients with human epidermal growth factor receptor 2 (Her-2)–negative advanced gastric cancer (GC).MethodsThe efficacy and survival time of a total of 126 patients who received the first-line treatment with oxaliplatin plus fluoropyrimidine (S-1 or capecitabine or fluorouracil), the second-line treatment with nab-paclitaxel, and the third-line treatment of immune checkpoint inhibitors between September 2019 and December 2021 were analyzed.ResultsA total of 42, 36, and 48 patients received CapeOX, FOLFOX, and SOX as a first-line treatment, respectively. All patients received nab-paclitaxel alone as a second-line treatment. In addition, 31, 56, and 39 patients received nivolumab, sintilimab, and tislelizumab as a third-line treatment, respectively. The median PFS1, median PFS2, and median PFS3 was 6.9 months [95% confidence interval (CI), 6.8–7.4], 5.5 months (95% CI, 5.3–5.7), and 3.5 months (95% CI, 3.4–3.7). The median PFS3 was 3.8 months (95% CI, 3.3–4.2) and 3.5 months (95% CI, 3.3–3.7) among the Epstein–Barr virus (EBV)-positive and EBV-negative, respectively (P = 0.09). In addition, the median PFS3 was 4.2 months (95% CI,3.6–4.7) and 3.5 months (95% CI, 3.3–3.6) in the patients with programmed death ligand 1 (PD-L1) combined positive score (CPS) ≥5 and CPS &lt;5, respectively (P = 0.02). The median OS was 17.4 months (95% CI, 17.2–18.1). The multivariate analysis showed that the two parameters were associated with a significantly longer OS: number of metastatic sites &lt;3 and PD-L1 CPS ≥5.ConclusionThe patients who received three lines of treatment had a long survival time, and the efficacy of immunotherapy was not affected by the EBV subtypes in advanced GC. The toxicity was managed, and the concept of full management needs to be confirmed in the future.
Integrated network pharmacology and experimental verification to investigate the mechanisms of YYFZBJS against colorectal cancer via CDK1/PI3K/Akt signaling
Authors: Li Jinxiao , Zhou Fangyuan , Shang Luorui , Liu Na , Liu Yuhan , Zhang Mengqi , Wang Shuhan , Yang Shenglan 
Published: November 2022

BackgroundColorectal cancer (CRC) is a common digestive tract malignancy with rising incidence and morbidity worldwide during recent years. Yi-Yi-Fu-Zi-Bai-Jiang-San (YYFZBJS), a traditional Chinese medicine formula, has showed positive effects against cancers. However, the mechanisms underlying its anticancer effects requires investigation.MethodsInformation on bioactive compounds, potential YYFZBJS targets, and CRC-associated genes, was obtained from public databases. The key targets and ingredients as well their corresponding signaling pathways were identified using bioinformatic approaches, including Kyoto encyclopedia of genes and genomes (KEGG) analyses, gene ontology (GO), and protein–protein interaction (PPI). Subsequently, molecular docking was used to verify the main compounds-targets. Potential YYFZBJS therapeutic effects against CRC were validated in vitro and in vivo.ResultsUsing pharmacological network analysis, 40 YYFZBJS active compounds and 21 potential anti-CRC targets were identified. YYFZBJS was an important regulator of CRC through various targets and signaling pathways, particularly the cell cycle and PI3K/AKT pathway. Additionally, YYFZBJS suppressed the proliferation of CRC cells. Flow cytometry showed that YYFZBJS induced apoptosis and cell cycle arrest in the G2/M phase. Western blotting analysis indicated that YYFZBJS reduced the protein levels of CDK1, p-AKT, and p-PI3K, without altering total PI3K and AKT protein levels. In vivo analysis found that YYFZBJS inhibited tumor growth and PI3K/AKT signaling in a mouse model of CRC.ConclusionAs predicted by network pharmacology and validated by the experimental results, YYFZBJS inhibited proliferation, induced apoptosis and arrested cell cycle progression in CRC by modulating the CDK1/PI3K/Akt signaling pathway.
A successful case of preimplantation genetic testing for monogenic disorder for aplasia cutis congenita
Authors: Yang Xiu-Fang , Shi Shang-Wen , Ye Yun , Chen Kang 
Published: November 2022

BackgroundAplasia cutis congenita (ACC), also called congenital cutaneous hypoplasia, is a serious disease in newborns. Children with ACC often die due to wound infections and bleeding. How the incidence of ACC can be reduced is a question that needs to be solved urgently.Case reportWe reported a mother who had delivered two children with ACC, both of whom were diagnosed with ACC type VI, skin defects, limb deformities, and congenital heart malformations. One infant died a few days after birth, and another died in utero in the second trimester. Genetic testing in both children showed a heterozygous mutation in the ITGB4 gene [17q25 exon 8, c. 794 dupC, (p. Ala266fs) and exon 15, c. 1860G &gt; A]. The mother later successfully gave birth to a healthy baby using Preimplantation Genetic Testing for Monogenic disorders(PGD-M).ConclusionThe PGD-M technique is highly valuable in reducing the incidence of ACC and improving the prognoses of newborns.
Case report: Clinical and genetic analysis of a family with nonsyndromic auditory neuropathy
Authors: Jiang Lan , Xu Hongen , Liu Danhua , Zhang Sen , Xu Ying 
Published: November 2022

BackgroundAuditory neuropathy (AN) is a hearing disorder caused by the failure of inner hair cells, auditory nerve synapses and/or auditory nerves. With the development of high-throughput sequencing technology, the genetic factors of AN have been revealed, and genetic testing has become an important tool for identifying different types of AN.Case descriptionTo study the genetic cause of nonsyndromic auditory neuropathy in a Chinese family. The family was from Henan Province with three affected individuals. The audiological examinations were performed on the affected individuals, and whole-exome sequencing was carried out on the proband. The suspected pathogenic variants screened by the bioinformatic analysis were validated using Sanger sequencing in the family members. We identified three novel variants c.3277G &gt; A (p.Glu1093Lys), c.4024-4G &gt; T, and c.898-2A &gt; G of the OTOF gene in the three children with AN. The first two variants were inherited from their father, and the third variant was inherited from their mother. A minigene assay was designed to test the effect of c.4024-4G &gt; T on splicing. The variants c.3277G &gt; A, c.4024-4G &gt; T, and c.898-2A &gt; G could be classified as likely pathogenic/pathogenic following the ACMG guidelines, and they are considered as the genetic causes for the patients in the family.ConclusionNew pathogenic/likely pathogenic variants of the OTOF gene were identified in a family with AN, enriching the mutational spectrum of the OTOF gene.
Clinical and ultrasound findings of pentalogy of Cantrell in a newborn: A case report
Authors: Wang Dan , Zheng Bin , Zhai Bo , Mo Juan , Yang Kaihua , Huo Yaling 
Published: November 2022

BackgroundPentalogy of Cantrell is a rare and deadly syndrome, manifesting as intracardiac anomalies and ventricular diverticulum. Echocardiographers have an insufficient understanding of pentalogy of Cantrell, which may lead to missed diagnoses, especially in cases lacking the most obvious signs.Case summaryOne of twin male infants, at a gestational age of 37 weeks, was found with a cardiac murmur and a pulsatile mass in the midline supraumbilical abdomen for 2 days. Echocardiography on admission indicated congenital heart disease. A cardiac murmur was detected in the 3–4 intercostal space and extensively spread. The infant was diagnosed with pentalogy of Cantrell by ultrasound and computed tomography angiography (CTA) preoperatively. The patient underwent heart deformity surgery and was followed up for 16 months. The patient's cardiac structure and function returned to normal.ConclusionIntracardiac anomaly and ventricular diverticulum are the primary manifestations of pentalogy of Cantrell. Pentalogy of Cantrell may be diagnosed by combining the ultrasound and CTA findings.
143.4 W high power combined white supercontinuum source using a (7 × 1) supercontinuum fiber combiner
Authors: Sun Chang , Ge Tingwu , Cao Kang , Wang Zhiyong 
Published: November 2022

We demonstrate a 143.4 W high power combined white supercontinuum (SC) source using a (7 × 1) SC fiber combiner. Based on the criteria of adiabatic tapering and brightness conservation, a (7 × 1) SC fiber combiner is designed and theoretically investigated, and the simulated results of the transmission efficiencies of laser at different wavelengths of the combiner verify that the combiner has the ability of combining white SC sources efficiently. Then, the (7 × 1) SC fiber combiner is fabricated, and three white SC fiber laser sources with average power of about 50 W are set up for beam combining experiment. Finally, a 143.4 W high power combined white SC source is achieved with high combining efficiency of 97.4%. and the corresponding combined SC spectrum ranges from 450 nm to 1700 nm, which remains consistent with the overall spectral range of the three SC sources. The experiment result indicates that the (7 × 1) SC fiber combiner is greatly capable of combining high power white SC sources efficiently, thereby increasing the average power of the white SC source significantly. To the best of our knowledge, this is the first demonstration of a fiber combiner for high power white SC sources with such a high combining efficiency.