bluuebunny/crossref_metadata_2025_split huggingface dataset:
Kata Netizen tentang Kesetaraan Gender dalam Sentimen Warganet Twitter
Authors: Azkiya Azka Al , Vega Iliana Patricia , Iqbal M. , Fatimah Zahra Nurul , Syafitri Utami Dyah 
Published: January 2022

Abstract: Gender equality is one of the goals in the Sustainable Development Goals. However, until now Indonesia is still having difficulties in achieving this goal. According to the United Nations Development Program (UNDP) data, Indonesia's Gender Inequality Index (GII) is ranked 107 out of 189 countries. In addition, according to The Global Gender Gap Index 2021 data by the World Economic Forum (WEF), Indonesia is ranked 105th out of 153 countries. This shows that Indonesia is still lagging behind in terms of gender equality. Therefore, this study aims to analyze the sentiments of Indonesian twitter netizens regarding gender equality in 2018-2021 and its accuracy. Data was collected from primary data, scraping twitter data with the keywords #kesetaraan and #gender in Indonesian. The method used is Lexicon-based Sentiment Analysis with AFINN-111 dictionary translated into Indonesian. The results obtained are that the percentage of positive sentiments tends to decrease from year to year except for 2021. On the contrary, the negative sentiments of Twitter tend to increase. This is due to controversial articles in RKUHP, RUU Cipta Kerja, Covid-19 pandemic, and the online gender-based violence. This shows that the gender equality in Indonesia is still minimal and needs to be improved.
Keywords: AFINN-111, gender equality, lexicon-based sentiment analysis, text mining, twitter
Abstrak: Kesetaraan gender termasuk tujuan pada Sustainable Development Goals. Namun hingga saat ini Indonesia masih kesulitan dalam mencapai tujuan tersebut. Menurut data United Nations Development Programme (UNDP), nilai Gender Inequality Index (GII) Indonesia menempati peringkat 107 dari 189 negara. Selain itu, menurut data The Global Gender Gap Index 2021 dari World Economic Forum (WEF), Indonesia menempati posisi ke-105 dari total 153 negara. Hal ini membuktikan gender di Indonesia masih belum setara. Oleh karena itu, penelitian ini bertujuan untuk menganalisis sentiment netizen twitter Indonesia mengenai kesetaraan gender pada 2018-202i dan akurasinya. Data dikumpulkan dari data primer yaitu scraping data twitter dengan keyword #kesetaraangender dan #gender dalam Bahasa Indonesia. Metode yang digunakan adalah Lexicon-based Sentiment Analysis dengan bantuan kamus AFINN-111 yang diterjemahkan dalam Bahasa Indonesia pada software python. Hasil yang diperoleh adalah persentase sentimen positif netizen twitter cenderung menurun dari tahun ke tahun kecuali 2021, sebaliknya sentimen negatif netizen twitter cenderung meningkat setiap tahun. Hal ini dikarenakan adanya pasal yang mengandung kontroversi pada Rancangan Kitab Undang-undang Hukum Pidana (RKUHP), RUU Cipta Kerja, adanya pandemi Covid-19, dan maraknya kekerasan berbasis gender online. Hal ini menunjukkan bahwa tingkat kesetaraan gender di Indonesia masih minim dan perlu untuk ditingkatkan kedepannya.
Kata kunci: AFINN-111, kesetaraan gender, lexicon-based sentiment analysis, text mining, twitter
Melting phase equilibrium relations in the MgSiO3-SiO2 system under high pressures
Authors: Moriguti Takuya , Yachi Yusuke , Yoneda Akira , Ito Eiji 
Published: January 2022

Abstract
Melting relations in the MgSiO3-SiO2 system have been investigated at 13.5 GPa using a Kawai-type multi-anvil apparatus. The system displays eutectic melting with the eutectic point located at SiO2/(SiO2+MgO) = 0.61 (in mol; which is denoted by XSi hereafter) and at 2350 ± 50 °C. Taking into account the eutectic compositions at lower pressures reported in previous studies, i.e., 0.556 at 1 GPa (Hudon et al. 2005) and 0.60 at 5 GPa (Dalton and Presnall 1997), the eutectic composition is slightly enriched in SiO2 with increasing pressure. The silica-rich eutectic composition is not consistent with the present peridotitic mantle composition (XSi = 0.43). Considering Si incorporation into iron alloys in a magma ocean, however, mass-balance calculations based on an E-chondrite model demonstrate that the silicate magma ocean could have XSi consistent with the present peridotitic mantle.
Host Microbiomes in Tumor Precision Medicine: How far are we?
Authors: D’Amico Federica , Barone Monica , Tavella Teresa , Rampelli Simone , Brigidi Patrizia , Turroni Silvia 
Published: January 2022

Abstract:The human gut microbiome has received a crescendo of attention in recent years due to the countless influences on human pathophysiology, including cancer. Research on cancer and anticancer therapy is constantly looking for new hints to improve the response to therapy while reducing the risk of relapse. In this scenario, the gut microbiome and the plethora of microbial-derived metabolites are considered a new opening in the development of innovative anticancer treatments for a better prognosis. This narrative review summarizes the current knowledge on the role of the gut microbiome in the onset and progression of cancer, as well as in response to chemo-immunotherapy. Recent findings regarding the tumor microbiome and its implications for clinical practice are also commented on. Current microbiome-based intervention strategies (i.e., prebiotics, probiotics, live biotherapeutics and fecal microbiota transplantation) are then discussed, along with key shortcomings, including a lack of long-term safety information in patients who are already severely compromised by standard treatments. The implementation of bioinformatic tools applied to microbiomics and other omics data, such as machine learning, has an enormous potential to push research in the field, enabling the prediction of health risk and therapeutic outcomes, for a truly personalized precision medicine.
Stimulants and Depressor Drugs in the Sleep-wake Cycle Modulation: The Case of Alcohol and Cannabinoids
Authors: Murillo-Rodríguez Eric , Carreón Cristina , Acosta-Hernández Mario Eduardo , García-García Fabio 
Published: January 2022

Abstract:A complex neurobiological network drives the sleep-wake cycle. In addition, external stimuli, including stimulants or depressor drugs, also influence the control of sleep. Here we review the recent advances that contribute to the comprehensive understanding of the actions of stimulants and depressor compounds, such as alcohol and cannabis, in sleep regulation. The objective of this review is to highlight the neurobiological mechanism engaged by alcohol and cannabis in sleep control.
Catalytic Applications of Recent and Improved Covalent Organic Frameworks
Authors: Sharma Venu , Nemiwal Meena , Kumar Dinesh 
Published: January 2022

Abstract:
Covalent Organic Frameworks (COFs) are porous crystalline materials that have emerged
as promising molecular materials in optoelectronics, catalysis, and gas storage applications. COFs exhibit
unique features, such as adaptability for various substrates, high chemical stability, tunability,
ease of working, and recyclability, making them efficient catalysts. The current mini-review article
discusses the synthesis and applications of COFs as catalysts. We hope that the present review will be
highly beneficial for researchers working in the area of COFs and their applications in catalysis.
Recent Advances in the Chemistry and Biological Activity of Sulfonamide
Derivatives
Authors: Yousif Mahmoud N.M. , El-Gazzar Abdel-Rahman B.A. , Hafez Hend N. , Fayed Ahmed A. , ElRashedy Ahmed , Yousif Nabil M. 
Published: January 2022

Abstract:
This review describes different synthetic methods for the preparation of sulfonamides.
Generally, sulfonamides are synthesized from sulfonyl chloride derivative and amino derivative. A
series of sulfonamide derivatives 7a-c, 8a,b, 9, 10, 11a,b, and 12 were synthesized in alkaline media
by reacting different amino compounds with a p-toluene sulfonyl chloride. Different amino derivatives
13, 15, 17, 19, and 21 reacted with p-tolyl sulphonyl chloride to afford sulfonylamides 14, 16,
18, 20, and 22. Different reactions of sulfonamide derivatives have been summarized. Generally, the
sulfonamide function group does not participate in any reactions, but other functional groups in the
compound are involved in various reactions. Sulfonamides exhibit different biological activities, e.g.,
antibacterial activity, anticancer activity, urease inhibitory activity, radical scavenging activity, carbonic
anhydrase inhibitory activity, non-competitive lactoperoxidase inhibitory activity, antifungal
activity, and anti-mycobacterial activity.
Global Comprehensive Outlook of Hantavirus Contagion on Humans: A
Review
Authors: Ashique Sumel , Sandhu Navjot K , Das Supratim , Haque Sk. Niyamul , Koley Kartick 
Published: January 2022

Abstract:
Hantaviruses are rodent viruses that have been identified as etiologic agents of 2 diseases in
humans: hemorrhagic fever with renal syndrome (HFRS) and nephropathiaepidemica (NE) in the Old
World and Hantavirus pulmonary syndrome (HPS) in the New World. Orthohantavirus is a genus of
single-stranded, enveloped, negative-sense RNA viruses in the family Hantaviridae of the order Bunyavirales.
The important reservoir of Hantaviruses is rodents. Each virus serotype has its unique rodent
host species and is transmitted to human beings with the aid of aerosolized virus, which is shed in
urine, faeces and saliva and hardly by a bite of the contaminated host. Andes virus is the only Hantavirus
identified to be transmitted from human-to-human and its major signs and symptoms include fever,
headache, muscle aches, lungs filled with fluid, etc. In early 1993, this viral syndrome appeared in the
Four Corner location in the southwestern United States. The only accepted therapeutics for this virus is
Ribavirin. Recently, serological examinations to identify Hantavirus antibodies have become most
popular for investigation among humans and rodent reservoirs.
The Chance of COVID-19 Infection after Vaccination
Authors: Khalili-Tanha Ghazaleh , Khazaei Majid , Soleimanpour Saman , Ferns Gordon A , Avan Amir 
Published: January 2022

Abstract:
The outbreak of COVID-19 that was first reported in Wuhan, China, has constituted a new
emerging epidemic that has spread around the world. There are some reports illustrating the patients
getting re-infected after recovering from COVID-19. Here, we provide an overview of the biphasic
cycle of COVID-19, genetic diversity, immune response, and a chance of reinfection after recovering
from COVID-19. The new generation of COVID-19 is a highly contagious and pathogenic infection
that can lead to acute respiratory distress syndrome. Whilst most patients suffer from a mild form of
the disease, there is a rising concern that patients who recover from COVID-19 may be at risk of reinfection.
The proportion of the infected population is increasing worldwide; meanwhile, the rate and
concern of reinfection by the recovered population are still high. Moreover, there is little evidence on
the chance of COVID-19 infection even after vaccination, which is around one percent or less. Although
the hypothesis of zero reinfections after vaccination has not been clinically proven, further
studies should be performed on the recovered class in clusters to study the progression of the exposure
with the re-exposed subpopulations to estimate the possibilities of reinfection and, thereby, advocate
the use of these antibodies for vaccine creation.
Channel Capacity of Molecular Signaling via Diffusion in Confined Microenvironment
Authors: Chude-Okonkwo Uche A.K. 
Published: January 2022

Aims:
To model molecular signal propagation in confined environment.

Background:
Molecular communication (MC) is rooted in the concepts of understanding, modeling,
and engineering information exchange among naturally and artificially synthesized nanosystems. To
develop or analyze an MC system, there is the need to model the communication channel through
which the molecular signal diffuse, from the transmitter to the receiver. Many models for the diffusion-
based MC channel have been proposed in the literature for evaluating the performance of MC
systems. Most of the contemporary works assume, and rightly so for some scenarios, that the MC
channels under consideration have infinite boundaries. However, this assumption becomes invalid in
bounded domains such as the interiors of natural cells and artificially synthesized nanosystems.

Objective:
In this paper, the model of molecular propagation in a confined. microenvironment is employ
to explore the effect of such an environment on the MC system.

Method:
The mutual information of the channel and specifically the closed-form expression of the
channel capacity of the molecular signaling in the confined geometry is derive.

Result:
Numerical results showing the variation in the channel capacity as the function of the channel
dimension are presented.

Conclusion:
Results showed that the channel capacity increases with the decrease in the channel dimension.
Subsequently, as the dimension of the channel tends to the nanoscale range typical of many
artificially synthesized nanosystems, the effect of the channel width on the capacity and by induction
on many other system metrics increases.
In Silico
Study of Pubchem Compounds for Solanum torvum as Antiviral Agent against SARS-CoV-2
Authors: Vaithilingam Subramaniyan , Vivekanandan Lakshmipathy , Krishna Moorthy S. 
Published: January 2022

Background:
The recent epidemic outbreak of a novel coronavirus called SARS-CoV-2 has caused suffering among many people in the form of respiratory tract infection. Currently, there are no targeted drugs, and effective treatment options remain limited.

Objective:
In order to rapidly discover new compounds for clinical purposes, in silico drug design and virtual drug screening have been initiated to identify new drug leads that target the main protease of the COVID-19 virus. Mpro is a key CoV enzyme, which plays a pivotal role in mediating viral replication and transcription, making it an attractive drug target for this virus.

Methods:
The present study was done to investigate the PubChem compounds of an ayurvedic herb Solanum torvum as an effective antiviral agent against COVID-19. The PubChem compounds like Torvoside H, Torvoside A, Torvoside E, Torvoside F, Torvonin A, 2,3,4-trimethyltriacontane, Torvanol A Q27134802, 5-hexatriacontanone, Jurubine, Tritriacontan-3-one, Torvanol A, Chlorogenone Spirostane-3,6-dione of Solanum torvum were downloaded from NCBI PubChem database acting as ligands for protein ligand docking. The 3D structure of the viral MPro (PDB ID: 6yb7) was retrieved from the RCSB PDB database. The active sites and binding sites were analyzed, and Docking molecular simulations were realized among a total of 12 ligands against COVID-19.

Results:
The PubChem compounds from the fruits of Solanum torvum showed good docking score and protein-ligand interaction, indicating that the PubChem compounds can cure the COVID-19 disease and act as an effective antiviral agent.

Conclusion:
Most of the PubChem compounds in the fruits of Solanum torvum showed better paramagnetic parameters.
Survivorship of Patients After Long Intensive Care Stay With Exploration and Experience in a New Zealand Cohort (SPLIT ENZ): Protocol for a Mixed Methods Study
Authors: Sutton Lynsey , Bell Elliot , Every-Palmer Susanna , Weatherall Mark , Skirrow Paul 
Published: January 2022

Background
Post Intensive Care Syndrome (PICS) was defined by the Society of Critical Care Medicine in 2012 with subsequent international research highlighting poor long-term outcomes; reduced quality of life; and impairments, for survivors of critical illness. To date, there has been no published research on the long-term outcomes of survivors of critical illness in New Zealand.

Objective
The aim of this study is to explore long-term outcomes after critical illness in New Zealand. The primary objectives are to describe and quantify symptoms and disability, explore possible risk factors, and to identify unmet needs in survivors of critical illness.

Methods
This will be a mixed methods study with 2 components. First, a prospective cohort study of approximately 100 participants with critical illness will be followed up at 1, 6, and 12 months after hospital discharge. The primary outcome will be disability assessed using the World Health Organization Disability Assessment Scale 2.0. Secondary outcomes will focus on mental health using the Hospital Anxiety and Depression Scale and the Impact of Events Scale-revised, cognitive function using the Montreal Cognitive Assessment (Montreal Cognitive Assessment–BLIND), and health-related quality of life using the European Quality of Life-Five Dimension-Five Level. The second element of the study will use qualitative grounded theory methods to explore participants experiences of recovery and highlight unmet needs.

Results
This study was approved by the New Zealand Northern A Health and Disability Ethics Committee on August 16, 2021 (21/NTA/107), and has been registered with the Australian New Zealand Clinical Trials Registry on October 5, 2021. SPLIT ENZ is due to start recruitment in early 2022, aiming to enroll 125 patients over 2 years. Data collection is estimated to be completed by 2024-2025 and will be published once all data are available for reporting.

Conclusions
Although international research has identified the prevalence of PICS and the extent of disability in survivors of critical illness, there is no published research in New Zealand. Research in this field is particularly pressing in the context of COVID-19, an illness that may include PICS in its sequelae.

Trial Registration
Australian New Zealand Clinical Trials Registry ACTRN1262100133588; https://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=382566&showOriginal=true&isReview=true

International Registered Report Identifier (IRRID)
PRR1-10.2196/35936
Relationship Between Time of Ischemia and Global Longitudinal Strain of Left Ventricle in Patients with ST-Segment Elevation Myocardial Infarction who were Successfully Reperfused
Authors: Widodo Setiawan , Mumpuni Hasanah , Taufiq Nahar 
Published: January 2022

Background: Coronary heart disease (CHD) is a problem that contributes to morbidity and mortality. Acute myocardial infarction with ST-Segment Elevation Myocardial Infarction (STEMI) is the most common manifestation of CHD. Cardiac muscle damage caused by STEMI is dynamic. The longer coronary is occluded, the area of ​​infarction will be greater than cause biomechanical changes in the myocardium. Speckle Tracking Echocardiography (STE) through a longitudinal strain parameter is a technique of assessing myocardial deformation and predicting the infarct area immediately after reperfusion therapy.
Method: This study was an analytic observational study with a cross-sectional method. Subjects were STEMI patients who were successfully reperfused and fulfilled the inclusion and exclusion criteria. Transthoracic echocardiography was performed within 12 hours after reperfusion. Strain analysis was done offline at the work station. A normality test was performed to determine the type of correlation test used. The influence of confounding factors was analyzed by bivariate and multivariate. A value of p <0.05 was said to be statistically significant.
Results: There were 43 subjects, ischemia time and global longitudinal starin (GLS) ​​were obtained. A normality test using Shapiro Wilk revealed that data distribution of the two variables was abnormal. The Spearman correlation test was used to assess the relationship between the two variables and found a negative correlation between the time of ischemia and GLS (r = -0.546; p = 0.000). Bivariate and multivariate analyses were performed to assess the influence of confounding factors. From the multivariate test, it was found that ischemia time was an independent factor influencing GLS value (p = 0.002).
Conclusion: There is a negative correlation between ischemia time and left ventricular GLS in STEMI patients who were successfully reperfused (r = -0.546; p = 0.000).
Risk Stratification and Mortality in Mitral Stenosis Patients
Authors: Maharani Erika , Mumpuni Hasanah , Hidayati Fera 
Published: January 2022

Background: Rheumatic mitral stenosis is the most common valvular abnormalities found in developing countries. Mortality risk in those populations was poorly investigated. In addition, hemodynamic, morphological, and mechanical factors that influence or predict outcome of rheumatic mitral stenosis have not been identified.
Aims: To determine predictive factors affecting outcome in rheumatic mitral stenosis patients.
Method: This retrospective cohort study was conducted at the National General Hospital Dr. Sardjito, Yogyakarta, Indonesia. The study recruited patients from the Valvular Heart Disease Registry from May 2014 to November 2020. New York Heart Association (NYHA) functional classification, invasive or surgical treatment, and incidence of death were recorded. The baseline rhythm from electrocardiography (ECG) was categorized as sinus rhythm and atrial fibrillation or atrial flutter. Based on the findings of trans thoracal echocardiography (TTE), subjects who had moderate to severe pure rheumatic mitral stenosis (or followed by mitral regurgitation and / or less significant tricuspid regurgitation as a natural history) and subjects with rheumatic mitral stenosis with a combination of other heart valve problems (of which severity more significantly) classified as groups I and II. The mitral valve area (MVA), mitral valve gradient (MVG), left atrial diameter (LA), and mean pulmonary artery pressure (mPAP) were then analyzed.
Results: A total of 477 patients (mean age 44.08 ± 10.93 years; 71.5% female) were enrolled in this study. There were 61 deaths during the median follow up of 393 days of which 35 deaths occurred in group I and 26 deaths occurred in group II. Kaplan Meier curve shows the 1 year survival rate is higher in group I than group II which is 92.5% and 92%, respectively. Bivariate followed by multivariate analysis showed MVG and mPAP were predictive risk factors for mortality in group I with p = 0.020 and p = 0.021. MVG parameter values evaluated from echocardiography with a cut-off of more than 10 mmHg and mPAP parameters with a cut-off of more than 50 mmHg were independent predictive risk factors for mortality. Thus, patients were at higher risk of death if MVG > 10 mmHg and mPAP > 50 mmHg
Conclusion: One year survival rate in group I was higher than group II. MVG and mPAP were risk factors for predicting mortality in group I.