bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pain Perception Following Computer-Controlled vs. Conventional Dental Anesthesia: Randomized Controlled Trial
Authors: Attia Sameh , Austermann Thomas , May Andreas , Mekhemar Mohamed , Conrad Jonas , Knitschke Michael , Böttger Sebastian , Howaldt Hans-Peter , Riad Abanoub 
Published: September 2022

Abstract
Background: The administration of local anesthesia (LA) in dental practice requires an injection which is the leading cause of patients’ fear and anxiety. Computer-controlled local anesthetic injector, designed to reduce the pain of performing local anesthesia by controlling the speed of injection. This single-blind randomised control trial aimed to compare the pain perception after computer-controlled local anesthesia (CCLA) and conventional LA. Methods: Dental students were both test and operator group versus an experienced dentist as additional operator of the LA. Data were collected regarding gender, age, medical condition, smoking habits. Additionally, operator feedback about the handling, pain at insertion and during infiltration, excitement (Dental Anxiety Scale), and complications were assessed. Results: Out of the 60 included participants, the majority were females (n = 41; 68.3%), medically healthy (n = 54; 90%), and did not receive medications (n = 54; 90%). While the participating students administered 62 (51.7%) injections, the experienced dentist administered 58 (48.3%) injections. The difference in pain perception on puncture between CCLA and conventional injections was not statistically significant (Sig. = 0.285); however, pain perception during injection was significantly different (Sig. = 0.029) between CCLA (1.65 ± 1.93) and conventional injections (2.49 ± 2.31). Conclusion: The professional experience influenced the pain perception while applying the LA. CCLA did not reduce pain on puncture significantly; however, pain perception during the injection was significantly reduced in the case of using CCLA devices compared to the conventional syringe.
Factors associated with pharmacological and psychotherapy treatments adherence in patients with Borderline personality disorder in Iran
Authors: Mohammadabadi Motahareh Sadat Mirhaj , Mohammadsadeghi Homa , Adrebili Mehrdad Eftekhar , Kolour Zahra Partovi , Kashaninasab Fatemeh , Shalbafan Mohammadreza 
Published: September 2022

Abstract
BackgroundBorderline personality disorder is a major mental illness characterized by sustained relationship instability, impulsive behavior, and intense affects. Adherence is a complex behavior, from minor refusals of treatment to abandonment of treatment, which can be affected by various factors. Therefore, the present study aimed to investigate the factors affecting pharmacological and psychotherapy adherence, patients’ attitude towards medication, and assessing medication and treatment adherence in patients with borderline personality disorder referred to an outpatient referral clinic in Tehran, Iran.MethodsThe study was a retrospective cohort study. The files of patients with borderline personality disorder referred to the outpatient clinic of the Tehran Psychiatric Institute were reviewed as the first step. In the next step, we contacted the patients and asked them to fill out the questionnaires. Data were collected using the Drug Attitude Inventory-10 (DAI-10) questionnaire and a researcher-made questionnaire to determine the attitude of patients toward pharmacological and psychotherapy treatment as well as therapeutic adherence. After collecting data, patients’ therapeutic adherence was divided into three groups: poor, partial, and good compliance. The data were analyzed by SPSS software version-22.Results Ninety-four patients were involved in the study, and fifty-four were women. In psychotherapy adherence, patients with higher education and hospital admission history have better compliance. Findings of DAI showed that 54 (57.4%) participants had negative attitudes toward medication, while 38 (40.4%) participants showed a negative attitude toward psychotherapy treatment. Additionally, the percentage of patients who had good psychotherapy adherence (44.7%) was higher than that of patients with good medication adherence (31.9%). The most common reasons for discontinuation of treatment were medication side effects (53.1%), dissatisfaction with the therapist (40.3%), and then fear of medication dependence (40%). Patients with higher education level and positive history of hospitalization in a psychiatric ward had better psychotherapy adherence (P<0.05).ConclusionsResults of the current study show that attitude toward psychotherapy is more favorable than pharmacotherapy among patients with BPD. The rationale may be medications are mainly prescribed for comorbid conditions, and do not have substantial effects on the BPD symptoms, resulting in low medication adherence.
Parallel Dual-channel Multi-label Feature Selection
Authors: Miao Jiali , Wang Yibin , CHENG Yusheng , Chen Fei 
Published: September 2022

Abstract
In the process of multi-label learning, feature selection methods are often adopted to solve the high-dimensionality problem in feature spaces. Most existing multi-label feature selection algorithms focus on exploring the correlation between features and labels and then obtain the target feature subset by importance ranking. These algorithms commonly use serial structures to obtain important features, which induces the excessive reliance on the ranking results and causes the loss of important features. However, the correlation between label-specific feature and label-instance is ignored. Therefore, this paper proposes Parallel Dual-channel Multi-label Feature Selection algorithm (PDMFS). We first introduce the dual-channel concept and design the algorithm model as two independent modules obtaining different feature correlation sequences, so that the algorithm can avoid the over-reliance on single feature correlation. And then, the proposed algorithm uses the subspace model to select the feature subset with the maximum correlation and minimum redundancy for each sequence, thus obtaining feature subsets under respective correlations. Finally, the subsets are cross-merged to reduce the important feature loss caused by the serial structure processing single feature correlation. The experimental results on eight datasets and statistical hypothesis testing indicate that the proposed algorithm is effective.
Comparison of remifentanil and esketamine in combination with propofol for patient sedation during fiberoptic bronchoscopy: a randomized trial
Authors: Nie Jia , CHen Wei , Jia Yu , Zhang Yu , Wang Haiying 
Published: September 2022

Abstract
Background
Ideal sedation and analgesia strategies for fiberoptic bronchoscopy have not been found. At present, propofol based sedation strategy still has some defects, such as respiratory depression and blood pressure drop, which is difficult to meet the requirements of safety and effectiveness at the same time. The aim of this study was to compare the clinical efficacy of propofol/remifentanil with propofol/esketamine for patient sedation during fiberoptic bronchoscopy. Method: Patients undergoing fiberoptic bronchoscopy were randomly assigned to receive either propofol/ remifentanil (PR group; n = 42) or propofol/esketamine (PK group; n = 42) for sedation and analgesia. Changes in blood pressure, heart rate, and oxygen saturation were monitored. The incidence of adverse reactions, the total amount of propofol usage were recorded. satisfaction level of patients and bronchoscopists was evaluated.
Results
After sedation, the arterial pressure and heart rate of patients in the PK group were stable without significant decrease. Decreases in diastolic blood pressure, mean arterial pressure, and heart rate were observed in patients in the PR group (P < 0.05). The dosage of propofol in the PR group was significantly higher than that in the PK group (144.43 ± 38.19 mg vs. 124.98 ± 35.30 mg, P = 0.012). Patients in the PR group showed more intraoperative cough (28 vs. 7, P < 0.01), postoperative vomiting (22 vs. 13, P = 0.076) and vertigo (15 vs. 13, P = 0.003). Bronchoscopists in the PK group showed more satisfaction.
Conclusion
Compared with remifentanil, the combination of esketamine with propofol in fiberoptic bronchoscopy provided more stable intraoperative hemodynamics, lower dosage of propofol, fewer incidence of adverse events, and greater bronchoscopists satisfaction.
Assessment of motor function and nutritional status in children with spinal muscular atrophy treated with nusinersen after loading period in western China
Authors: Yang Hua , Tao Qiuji , Li Dan , Yang Jie , Cai Qianyun , Gan Jing , Huang Shaoping , Luo Rong 
Published: September 2022

Abstract
Introduction: The treatment of children with spinal muscular atrophy (SMA) includes disease-modifying drugs such as nusinersen. Our aim was to summarize our experience regarding the efficacy and safety of nusinersen and nutritional status in children with SMA in western China. Methods: In this retrospective study, data from all patients with a genetically confirmed diagnosis of SMA before 18 years of age who were treated with nusinersen were collected before initiation of treatment and after 2 months of treatment. We assessed the motor function of patients with SMA using standardized scales, nutritional status and side effects of nusinersen.Results: 46 patients aged < 18 years were enrolled in this study. The patients had 2 to 3 copies of the survival motor neuron 2(SMN2) gene. After 2 months of treatment, motor function of SMA type 1, 2, and 3 improved. Children with SMA have nutritional disorders, and SMA1 patients are the most malnourished. No serious adverse effects were observed. Conclusion: Our study included patients with SMA1, SMA2, and SMA3. Motor function of all pediatric SMA patients improved after 2 months of loading period nusinersen treatment. Children with SMA, especially SMA1, are prone to malnutrition; thus, nutritional management of SMA patients should be enhanced. Our study also suggests that nusinersen is safe to use, as no major side effects requiring treatment discontinuation have been reported.
Stochastic fixed-time synchronization for multilayer derivative dynamic Cohen-Grossberg networks via quantitative control
Authors: Tan Fei , Zhou Lili 
Published: September 2022

Abstract
The implementation of fixed-time synchronization is a challenging problem for dynamic networks with derivative links. When there are derivative links in multilayer heterogeneous dynamic networks, it is difficult to obtain the fixedtime stable synchronization criteria via using the conventional Lyapunov function. So we choose a special Lyapunov function to solve the fixed-time stable synchronization criteria. In this paper, different from the comprehensive method used in lots of literature, to design and solve the fixed time controller, we use the analysis method to design a fixed time control strategy. When this strategy is used for the fixed-time synchronization of multilayer Heterogeneous networks with Cohen-Grossberg neural subnet, it will result in the designed controller does not contain differential terms, so as to reduce the difficulty in the design of fixed time controller. To be closer to reality, we consider multilayer neural networks with stochastic disturbances and nonlinear connections. When designing the controller, considering the actual communication constraints, we introduce quantization into the designed controller. Under the theoretical framework, we find that the upper limit for function of synchronization time is related to the quantization intensity, parameters of the designed Lyapunov function, parameters of the controller and a maximum eigenvalue related to the structure of multilayer Cohen-Grossberg neural networks. Finally, a simulation is supported to illustrate the effective of the derived theoretical framework.
Effects of mitochondrial dysfunction on bone metabolism and related diseases: a scientometric study from 2003 to 2022
Authors: Zhang Wei , Xia Chang-Liang , Ma Jun-Nan , Li Jia-Xuan , Chen Qi , Ou Shuan-Ji , Yang Yang , Qi Yong , Xu Chang-Peng 
Published: September 2022

Abstract
Background: In recent years, mitochondrial dysfunction has been extensively studied and published, but research in the effects of mitochondrial dysfunction on bone metabolism and related diseases is only just beginning. Furthermore, no studies have been carried out to systematically illustrate this area from a scientometric point of view. The goal of this research is to review existing knowledge and identify new trends and possible hotspots in this area.Methods: All publications related to the relationship between mitochondrial dysfunction and bone metabolism and related diseases during 2003 to 2022 are searched at the Web of Science Core Collection (WoSCC) on May 7, 2022. Four different analytical tools: VOSviewer 1.6.18, CiteSpace V 6.1, HistorCite (12.03.07) and Excel 2021 were used for the scientometric research.Results: The final analysis included 555 valid records in total. Journal of Biological Chemistry is the most famous journal in this field. China, the United States, and Korea are the most productive countries. Blanco FJ, and Sun L are the main researchers with significant academic influence. Current research hotspot are basic research on mitochondrial dysfunction and prevention or treatment of bone metabolism related diseases. Conclusion: The study of the consequences of mitochondrial dysfunction on bone metabolism and associated diseases is advancing rapidly. A number of prominent researchers have published extensive literature and are widely cited. Future research in this area will focus on oxidative stress, aging, gene expression, and the pathogenesis of bone metabolism-related diseases.
Wheat blast disease impact on global grain yield under climate change
Authors: Pequeno Diego Noleto Luz , Ferreira Thiago Berton , Fernandes José Mauricio Cunha , Singh Pawan Kumar , Pavan Willingthon , Sonder Kai , Robertson Richard , Krupnik Timothy , Erenstein Olaf , Asseng Senthold 
Published: September 2022

Abstract
Wheat blast is a devastating fungal disease of wheat crops. The disease emerged in Brazil in the 1980s and is now spreading across continents, so it is urgent to calculate the potential for wheat blast spread and estimate the impact on wheat yield globally. By coupling a wheat crop simulation model with a new wheat blast model, quantitative estimates of wheat blast vulnerability were made with geographical precision. Under current climatic conditions, 6.4 million hectares of arable land is potentially vulnerable to wheat blast. Simulations of a warmer and more humid climate in the future show how wheat blast may spread, particularly in the southern hemisphere, and reduce global wheat production by 69 million tons per year (13% decrease) by mid-century.
First occurrence of Sclerotium rolfsii associated with collar and root rot disease of faba bean and its in vitro chemical control
Authors: Paul Swapan Kumar , Gupta Dipali Rani , Mahapatra Chandan Kumar , Sohrawardy Hossain , Hossain Delwar M. , Islam Tofazzal 
Published: September 2022

Abstract
Faba bean (Vicia faba L.), a promising grain legume, widely grown in central and northern part of Bangladesh. Disease symptoms resembling to collar and root rot was observed in an experimental field of Bangladesh Agricultural University, Mymensingh, Bangladesh. Disease incidence was ranged between 11–19%. Water-soaked sunken lesions were appeared on the collar region followed by the expansion of rotten areas along with white mycelial mass. The associated pathogen was isolated and identified as Sclerotium rolfsii (Teleomorph: Athelia rolfsii) based on the morphological characteristics and sequence analysis of ITS regions. The isolates grew well in both PDA and OMA media but optimum radial growth (3.31 cm/day) was observed in PDA media. The optimum temperature and pH for radial growth were 30°C and 7.0, respectively. Host range assay revealed that S. rolfsii isolates were strongly virulent to several other important crops such as tomato, brinjal chili, pea and chick pea indicating its potential threat to future agricultural production. Although the isolates were sensitive to Amistar Top, Score and Provax fungicides but Provax was more effective to inhibit the mycelial growth of S. rolfsii at 10 ppm. To best of our knowledge, this is the first confirmed report of S. rolfsii causing collar rot of faba bean in Bangladesh and their in vitro chemical control.
Absence of New T-wave Inversion After Successful Primary Percutaneous Coronary Intervention
Authors: Jamil Araj , Ahmed Shahid , Ahmed Ishfaq , Rasheed Ghulam , Ahmed Bilal , Bhutto Aslam Latif , Hussain Sabir 
Published: September 2022

Abstract
BACKGROUNDNew beginning of T Wave Inversion (TWI) after the primary PCI was taken as no negative T waves on the presenting ECG and considered as a new TWI case. Major Adverse Cardiac Events (MACE) which included occurrence of nonfatal myocardial infarction, cardiovascular mortality, and re-hospitalization for heart failure was taken as primary endpointThe primary aim of the study was to determine the frequency of absence of new T wave inversion (TWI) after successful Primary Percutaneous Coronary Intervention (PPCI) in patients. The secondary aim of the study was to assess the association between the development of new TWI after successful PCI and MACE after 30-days of the procedure.METHOD This 06 months prospective observational study was conducted at the Department of Interventional Cardiology at the National Institute of Cardiovascular Disease (NICVD), Karachi, Pakistan.Non-probability, Consecutive Sampling was used to collect the study sample. All patients aged between 18 to 65 years, both male and female, who presented with acute STEMI (within 12 hours of chest pain) and underwent successful primary PCI were included in this study. RESULTSA total of 310 patients were enrolled with no missing data and incomplete information was found. Out of 310, most of the study population was male (237) as compared to female (73). Non-Diabetic, Non-hypertensive, Non-Smoker, Non-Obese, and with no Family History were not statistically significant with new TWI after 30 min and 48 hrs successful PCI in acute STEMI patients. MACE after 30 days was observed to be a not statistically significant factor as well with respective with new TWI after 30 min and 48 hrs successful PCI in acute STEMI patients, however, all patients were observed to be free from MACE after 30 daysCONCLUSION Overall in our study population, we have observed new TWI frequently observed in all age groups with gender distribution and comorbid factors. Although our primary objective was straightly observed in the minimal population as absence of T wave frequency observed to be minimal.
Exploration and Exploitation Methods Using (1+1)-Evolutionary Algorithms for Better Ranking Models
Authors: Ibrahim Osman Ali Sadek 
Published: September 2022

Abstract
Exploration and Exploitation methods in Evolutionary Algorithms (EA) play a fundamental role for obtaining an optimal solution. Exploration technique target is for search large portion of the search space, while Exploitation procedure is used for converge the current solution to the nearest local or global optimal solution. Example of Exploration procedure in EA is mutation process and Exploitation procedure can be accomplished using crossover process or better initialization at the beginning. This paper uses four probability distributions random generator for mutation process in (1+1)-Evolutionary Algorithms ((1+1)-EAs) for examining their mutation behaviors. In addition, this paper uses ranking models from Dependent Click Model and Linear Regression algorithms as initial solution in (1+1)-EAs for better Exploitation. From the experimental results, the exploration process using Gaussian Random Number (GRN) generator with exploitation procedure using Linear Regression (LR) model and Dependent Click (DC) model initialization in (1+1)-EAs outperformed other methods for evolving steps on training dataset. On the other hand, Levy Random Number generator with LR outperformed other methods used for results on unseen test datatset, while GRN is the strongest competitor compared to Levy for these Predictive rank results. Furthermore, state-of-the-art method in the previous studies Combining Simulated Annealing with (1+1)-Evolutionary Strategy outperformed the predictive ranking and evolving results on testing and training data for both with or without initialization by other Linear ranking compared to novel (1+1)-Evolutionary Gradient Strategy method and other (1+1)-Evolutionary Strategy. This paper demonstrated the results and findings obtained using MQ2008 dataset and providing their package codes.
Biofilm competency of Desulfovibrio vulgaris Hildenborough facilitates colonization in the gut and represses adenoma development in a rat model of colon cancer
Authors: Amos-Landgraf James , busi Susheel , De Leόn Kara , Montonye Dan , Wall Judy 
Published: September 2022

Abstract
Sulfate-reducing bacteria including Desulfovibrio spp. have been associated with suppression of tumor incidence and growth of colorectal cancer (CRC) in human and animal studies. However, other studies suggest that Desulfovibrio spp. are decreased in healthy controls. To address this dichotomy, we treated a rat model of CRC with biofilm-forming and biofilm-deficient strains of Desulfovibrio vulgaris Hildenborough (DvH) to evaluate tumor development. The biofilm-forming DvH stably colonized the rat colon after neonatal administration. Contrarily, the biofilm-deficient strain was undetectable one-week after treatment. The colonic adenoma burden was significantly reduced in the biofilm-forming DvH treated rats compared to the control and biofilm-deficient group. In contrast, known mucin degrading bacteria were increased in the control groups correlating with increased expression of the colonic mucin gene, MUC2, and DNA repair genes MSH2, ATM, and MGMT. This indicates that sulfate reducing biofilm forming bacteria can colonize and protect the colonic epithelium from adenoma initiation.
Risk factors for prolonged postoperative ileus after intracranial tumor surgery
Authors: Miao Fangfang , Fan Long , Feng Xuexin , Feng Kunpeng , Jia Bin , Wang Tianlong 
Published: September 2022

Abstract
Background: Prolonged postoperative ileus (PPOI) is the most frequent postoperative complication and significantly increases postoperative morbidity and medical costs. The objective of this study was to identify the incidence and independent risk factors of PPOI after intracranial tumor surgery, so as to allow for advanced planning to reduce the incidence of PPOI.Methods: After retrospective review of data from patients who underwent intracranial tumor surgery from January 2018 to March 2021, a total of 1135 patients (447 males and 688 females; median age 51 [41–61] years) were included in the study. Clinical parameters were compared between patients with PPOI and those without PPOI. Multivariate logistic regression analysis was performed to identify independent risk factors associated with PPOI.Results: In total, 121 of 1135 (10.7%) patients experienced PPOI. Operation time ≥4 h (OR = 1.71, 95% CI 1.07–2.74, p = 0.03) and no flatus within postoperative 24 h (OR = 1.86, 95% CI 1.25–2.76, p = 0.002) were the independent risk factors of PPOI. In addition, in-hospital length of stay was longer and medical costs were higher in patients with PPOI than in those without PPOI (all p < 0.001).Conclusions: Independent risk factors for PPOI are operation time ≥4 h and no flatus within postoperative 24 h. Patients with these risk factors should be carefully monitored, and steps such as attempting to shorten the duration of surgery and utilizing measures to facilitate flatus should be taken to minimize the development of PPOI and prevent the occurrence of secondary adverse events.Trial registration: The study protocol was registered at Chinese Clinical Trial Registry (ChiCTR2200057468) on 13/03/2022.