bluuebunny/crossref_metadata_2025_split huggingface dataset:
PATIENT AND CARE PARTNER VALUES WHEN CONSIDERING DEMENTIA TREATMENT OUTCOMES
Authors: Butt Maayra , Drakes Josiah , Rosa Paola , Bahti Melanie , Harkins Kristin , Karlawish Jason , Halpern Scott , Auriemma Catherine 
Published: January 2025

Abstract
We sought to understand how persons living with dementia (PWD) and their family care partners value hypothetical treatment outcomes relative to one other using a point allocation task. Participants distributed 100 points across six potential outcomes based on perceived relative importance. Outcomes included slowed decline in brain function, reduced agitation and combativeness, reduced family caregiver stress, prolonged ability to perform activities of daily living, increased time living at home, and increased socialization and engagement. Equality of distributions between outcome scores and between subgroups were compared using Wilcoxon signed-rank and rank-sum tests, respectively. 201 individuals participated (n=154 (77%) care partners and n=47 (23%) PWD). Across all participants, slowing declines in brain function scored highest (20, IQR 10, 30, p&lt; 0.05 for all pair-wise comparisons). Care partners compared to patients more highly valued reduced agitation and combativeness (15.5, (IQR 10, 25) vs 10 (IQR 3, 16), p&lt; 0.001). Patients compared to care partners more highly valued reducing family caregiver stress (16 (IQR 10, 30) vs 10 (IQR 5,20), p=0.003). Among care partners, those whose loved one had mild dementia more highly valued slowing declines in brain function (20 (IQR 10, 37.5) vs 15 (IQR 10, 25), p=0.02). Conversely, care partners of those with moderate or severe dementia more highly valued reducing agitation and combativeness (20 (IQR 10, 25) vs 12.5 (7.5, 21) p=0.007). PWD and dementia care partners expressed differing values when considering treatment outcomes. The development of future treatments should consider the most valued outcomes and disease severity to enhance potential treatment satisfaction.
PHYSICAL ATTRIBUTES LINKED TO FRAILTY IN NURSING HOME RESIDENTS: INSIGHTS FROM A CROSS-SECTIONAL STUDY
Authors: Chan Francis Kin Tung , Fung Chi Tat , Chan Ka Po , Yang Yijian 
Published: January 2025

Abstract
Frailty is a complex geriatric condition characterized by reduced physiological reserve and increased risk of adverse outcomes. Older adults in nursing homes are generally frail and have poor mobility. However, research on frailty in nursing homes is scarce compared to community settings, particularly on its association with mobility and postural stability. A cross-sectional analysis of baseline data from a two-arm cluster randomized controlled trial was conducted, involving 133 participants aged 60 and above from 20 Hong Kong residential care homes. The FRAIL-NH scale was used to assess frailty through factors such as fatigue, mobility, and nutrition for nursing home residents. Walking speed was assessed by the GAITRite computerized walkway system, postural stability with the Swaymeter. Multiple regression statistical analysis was conducted to identify associations between FRAIL-NH and physical attributes. Walking speed (Standardized Coefficients = -0.38, p&lt; 0.001), anterior-posterior body sway (Standardized Coefficients = -0.288, p=0.02), and BMI (Standardized Coefficients = -1.98, p=0.018) were significantly associated with FRAIL-NH, with walking speed as the strongest predictor account for 19.6% of total variance. However, medial-lateral body sway did not show significant association with FRAIL-NH. Additionally, no significant correlation was observed between specific muscle strength measures and FRAIL-NH. Our study highlights walking speed and anterior-posterior sway as key indicators of frailty in nursing home residents. These results identify the need for focused interventions that improve balance and mobility, which may potentially decrease frailty and risk of falling for this vulnerable population. Further research is crucial for developing effective frailty interventions in nursing homes.
PHYSICAL, COGNITIVE AND MENTAL CHARACTERISTICS AND DIGITAL HEALTH TECHNOLOGY USE AMONG PREFRAIL OLDER ADULTS
Authors: Ohta Takahisa , Hatanaka Sho , Shida Takashi , Kojima Narumi , Osuka Yosuke , Okamura Tsuyoshi , Hirano Hirohiko , Awata Shuichi 
Published: January 2025

Abstract
Remote interventions for prefrail older people are more feasible than for frail older people, but the benefits of using digital health technologies (DHT) have not been comprehensively investigated. This cross-sectional study examined whether DHT use in prefrail older people is associated with better physical/cognitive/mental function. Participants aged ≥70 years with prefrailty, as defined by the Japanese Cardiovascular Health Study criteria, were recruited from the Itabashi Longitudinal Study on Aging between 2022–2024. Exclusion criteria comprised impaired activities of daily living, Mini-Mental State Examination (MMSE) scores &lt; 23, or physician-diagnosed dementia. DHT ownership and usage, such as messaging, searching, video calls, and video viewing, were self-reported. Physical characteristics included muscle strength, body mass index, and skeletal muscle mass index. Cognitive function was assessed by MMSE, and mental health was evaluated using WHO-5. Binomial logistic regression, adjusted for demographics, lifestyle, and socioeconomic status, calculated adjusted odds ratios (aORs) and 95% confidence intervals (CIs), with non-DHT ownership as the reference. Among 2,681 participants, eligible 862 (mean age 77.0±4.5 years, 44.0% women) were analyzed. DHT ownership was inversely associated with lower handgrip strength (&lt; 28kg for men, &lt; 18kg for women) (aOR: 0.68; 95% CI: 0.47–1.00) and lower MMSE (&lt; 27) scores (aOR: 0.65; 95% CI: 0.44–0.98). The use of searching (aOR: 0.49; 95% CI: 0.28–0.83) and video calls (aOR: 0.58; 95% CI: 0.38–0.88) were inversely associated with lower WHO-5 scores. These findings suggest DHT may support physical/cognitive/mental health in prefrail older adults.
PILOT RESULTS OF A GAMIFIED TRAINING FOR CERTIFIED NURSING ASSISTANTS ON AGE-FRIENDLY HEALTHCARE
Authors: Wihry David , Wehry Susan , Hunt Angela , Metcalf Judith , Spofford Victoria 
Published: January 2025

Abstract
Certified Nursing Assistants (CNAs) are an integral part of supporting the health and wellbeing of older adults within long-term care (LTC) settings. As the Age-Friendly Healthcare movement expands to include LTC, it will be important to ensure effective and accessible training for CNAs on Age-Friendly Healthcare competencies. This poster will present the results of a pilot study examining the usability and satisfaction with an app-based training on the 4Ms of Age-Friendly Healthcare (What Matters, Medication, Mentation, Mobility). The modules are tailored to the practice needs of CNAs and use principles of gaming to increase uptake of the training. A post training survey was distributed to 127 CNAs from eight LTC communities who completed the curriculum, with a 79% response rate. 78% agreed they would prefer to learn this way versus alternative learning methods such as online learning, classroom learning, etc. (12% neither agreed nor disagreed, 10% disagreed). 85% agreed that they believe gamification is a successful delivery method for learning (8% neither agreed nor disagreed, 7% disagreed). 80% agreed that they would recommend the training program to their co-workers (13% neither agreed nor disagreed, 7% disagreed). The number of participants stating that they had a “very good” level of knowledge of Age-Friendly Healthcare increased from 25% to 39% using a retrospective pre-post rating. Qualitative feedback highlighted interactivity, brevity, and ability to engage the individual as key themes about the value of the training modules. Implications for use of gamification in Age-Friendly Healthcare training will be presented.
PREDICTING ALL-CAUSE MORTALITY USING THE SARCOPENIA PHENOTYPE: EVIDENCE FROM THE KFACS
Authors: Kim Miji , Shin Hyung Eun , Lee Daehyun , Jung Heeeun , Jang Jae Young , Cho Hyunjin , Lim Nahyun , Won Chang Won 
Published: January 2025

Abstract
The Global Leadership Initiative on Sarcopenia (GLIS) has sought to establish a consensus on sarcopenia diagnosis, which involves reduced muscle mass and strength. We investigated the association between sarcopenia phenotypes (low muscle mass, muscle strength, and physical performance) and all-cause mortality. We conducted a prospective 6-year follow-up analysis of 2,400 older adults (52.8% women; mean age 76.0±3.9 years) enrolled in the Korean Frailty and Aging Cohort Study. Participants were included if they had undergone dual-energy X-ray absorptiometry, handgrip strength testing, and physical performance assessments at baseline (2016–2017). Discrete-time Cox proportional hazards models evaluated the association between sarcopenia and all-cause mortality. According to the GLIS criteria, the prevalence of sarcopenia was 15.4% in men and 7.5% in women. Totally, 203 deaths occurred, with 6-year mortality rates of 2.1 (95% confidence interval [CI]: 1.9–2.5) per 100 person-years in individuals without sarcopenia, and 4.8 per 100 person-years (95% CI: 3.6–6.3) in those with sarcopenia. After adjusting for potential confounders, reduced muscle mass and muscle strength were significantly associated with an increased risk of all-cause mortality (hazard ratio [HR]: 1.56, 95% CI: 1.09–2.24). Moreover, the presence of all three criteria of sarcopenia was associated with an increased risk of all-cause mortality (HR: 1.87, 95% CI: 1.27–2.67), while reduced muscle mass and physical performance were not significantly associated with mortality (p=0.06). In conclusion, the conceptual definition of sarcopenia outlined by the GLIS, which includes both reduced muscle mass and muscle strength, is associated with premature mortality among community-dwelling older adults.
PREVENTION OF SEVERE EVENTS IN OLDER PEOPLE IN SWEDEN – POSSIBILITIES AND CHALLENGES
Authors: Bravell Marie Ernsth , Johansson Linda , Finkel Deborah 
Published: January 2025

Abstract
Older adults are at high risk of malnutrition, falls, pressure ulcers and poor oral health. In Sweden the quality register Senior Alert is trying to improve the preventive work among older people. This study used data from Senior Alert to understand how the preventive work process functions in different care settings. Data included 2957 persons that were assessed in Senior Alert: 864 in nursing homes, 226 in home care and 1829 in hospital. Descriptive and comparative analyses were performed to understand how many were assessed as having risk, and then the actions planned and follow-ups. The results demonstrated that people who were assessed in hospital had risks of some kind in almost half of the cases (46%), in comparison to nursing homes (29%) and home care (8%). Planned actions differed between the settings: in nursing homes, actions were more often planned to prevent poor oral health (29%) whereas hospital staff more often planned actions to prevent falls (73%), malnutrition (71%) and pressure ulcers (57%). Planned actions were significantly less in home care. Follow-ups follow the same patterns, where follow-up in home care were significantly smaller than in nursing homes and hospitals in all areas. Home care provides good opportunities to provide preventive care, as it is more continuous than, for example, hospital care. Additional analyses identified particular actions planned and performed, for a fine-grained investigation of preventive care in Sweden.
REACTANCE/HEIGHT AS A POTENTIAL BIOIMPEDANCE INDICATOR OF FRAILTY AMONG COMMUNITY-DWELLING OLDER ADULTS
Authors: Lafontant Kworweinski , Zamarripa Estefania , Tice Abigail , Blount Amber , Suarez Jethro Raphael , Kim Dahee , Stout Jeffrey , Thiamwong Ladda 
Published: January 2025

Abstract
Frailty is prevalent among older adults and is characterized by reductions in physical function and muscle quality. Despite the emerging clinical utility of bioelectrical impedance analysis (BIA), little is known about how bioimpedance indices, such as phase angle (PhA), Levi’s Muscle Index (LMI), reactance/height (Xc/Height), and resistance/height (R/Height), relate to physical function (i.e., handgrip strength, postural sway, Timed-Up-and-Go, Sit-to-Stand, Short Physical Performance Battery) and frailty. This study aimed to investigate these relationships in community-dwelling older adults. We cross-sectionally compared physical function measures and bioimpedance indices between frail, pre-frail, and robust categories as determined by the FRAIL questionnaire in 150 community-dwelling older adults (female, n = 137; age = 73.9 ± 6.9 years; BMI = 30.5 ± 6.4 kg/m2) using Kruskal-Wallis H and one-way ANOVA tests. Spearman rho (ρ) and Pearson r correlation coefficients were used to assess relationships between variables. PhA (r = -0.15, p = 0.07) and LMI (ρ = 0.05, p = 0.57) were not significantly associated with FRAIL scores, unlike Xc/Height (r = -0.29, p &lt; 0.001) and R/Height (r = -0.20, p = 0.02). Among the bioimpedance indices, only Xc/Height differed significantly between frailty categories (F(2,147) = 6.55, p = 0.002) while all physical function assessments except postural sway differed between the categories (p &lt; 0.05). These results suggest that only Xc/Height may be indicative of frailty among older adults. However, these conclusions may be limited by the use of the FRAIL questionnaire; future research should compare LMI and PhA using multiple frailty assessments.
RELIABILITY OF REMOTE SELF-ADMINISTRATED DIGITAL COGNITIVE ASSESSMENTS
Authors: Huynh Duong , Patterson Mary , Huang Bin 
Published: January 2025

Abstract
Early diagnosis of cognitive impairment and dementia relies on comprehensive, evidence-based cognitive assessment, which currently requires a clinic visit and access to skilled healthcare providers. This poses a challenge for people who live in areas with inadequate primary care services and those who have economic, insurance, or other transient hardships (transportation, time, etc.) that limit their access to healthcare services. Digital cognitive assessments (DCAs) with remote testing capabilities have emerged as an efficient and cost-effective solution. The aim of this study was to validate the reliability of BrainCheck, a platform for DCAs, when self-administered remotely. A total of 46 participants (60.9% female; age range 52-76) remotely completed a battery of eight BrainCheck cognitive assessments twice on the same device (iPad=8, iPhone=5, laptop=33): the participants self-administered in one session and were administered by a research coordinator (examiner) in the other session. The inter-session interval (ISI) varied across participants, from within the same day to 21 days apart. Testing outcomes, including the duration of time needed to complete the battery, the raw score from each assessment, and the raw overall score, were compared between the two sessions. We found moderate or good agreement between self- and examiner-administered performance, with intraclass correlation ranging from 0.59 to 0.83. Results from mixed-effects modeling further confirm the non-significant difference between self- vs. examiner-administered testing performance, which is independent of other factors including testing order, ISI, device, and participants’ demographic characteristics. These results demonstrate the feasibility of remote self-administration using BrainCheck.
RESILIENCE COMPONENTS, POSTOPERATIVE COMPLICATIONS, AND QUALITY OF LIFE DETERIORATION AFTER PANCREATECTOMY
Authors: Choi Jung-Yeon , Kim Kwang-il 
Published: January 2025

Abstract

Background
Resilience, the ability to adapt positively to adversity, remains a multisystemic process with no standardized objective measurement methods. The aim of this study was to identify the association between resilience components and frailty, postoperative complications, and quality of life changes after pancreatectomy in older patients.

Methods
This study evaluated older patients (aged ≥ 65) scheduled for pancreatectomy between August 2020 and December 2023. Patients who underwent a Comprehensive Geriatric Assessment and signed informed consent were included. Frailty was determined by multidimensional frailty score more than 5. Neurohumoral resilience was measured using the ACTH stimulation test, cardiovascular autonomic function using orthostatic blood pressure measurement, and cognitive-motor function using dual-task gait tests. The primary outcome was postoperative complications, and the secondary outcome was the deterioration in quality of life one year after pancreatectomy.

Results
A total of 57 patients were included in the analysis. Among them, 17 (29.8%) were classified as frail, 10 patients (17.5%) experienced postoperative complications, and 12 patients (24.5%) had worsened quality of life after one year. Low blood pressure and slow usual gait speed was associated with frailty. Diminished cortisol responsiveness correlated with frailty and postoperative complications. Quality of life deterioration was associated with differences between dual-task (serial 7) gait speed and fast gait speed.

Conclusion
This study highlights the potential association between multidomain resilience components, frailty, and clinical outcomes in older patients undergoing pancreatectomy. Future research should focus on developing robust, objective, and reliable resilience metrics for clinical use.
SAFETY AND EFFECTS OF HEAT-INACTIVATED LACTOBACILLUS PARACASEI D3.5 (LPD3.5) ON MENTAL WELLBEING IN OLDER ADULTS
Authors: Lloyd Amanda , Warren-Walker Alina , Holt Nigel , Lynch Doug , Kay Denis , Stephens Kevin , Jain Shalini , Yadav Hariom 
Published: January 2025

Abstract
A healthy gastrointestinal (GI) tract and its microbiome are crucial for maintaining overall health, while microbiome abnormalities can lead to various health issues including brain health and impact quality of life (QOL). These issues are often linked to dysregulation of the gut-brain axis. Although probiotics and prebiotics are common strategies to improve gut and brain health, they have limitations. Postbiotics, offering stable and predictable exposure, present an attractive alternative. In this open-label pilot study, we tested PoZibio®, a postbiotic containing heat-inactivated Lactobacillus paracasei D3.5 (LpD3.5), in 13 healthy older adults (≥50 years) over 30 days to assess its safety, tolerability, and impact on GI function and QOL. Participants consumed four LpD3.5/PoZibio capsules daily and completed the SF-36 and GSRS surveys before and after the study. PoZibio was found to be safe and well-tolerated, with notable improvements in emotional well-being and gastrointestinal symptoms. However, due to the study’s open-label design, small sample size, and short duration, these findings should be interpreted cautiously. Larger, placebo-controlled trials are needed to confirm PoZibio’s potential benefits for the gut-brain axis and overall health.
SELF-REPORTED FALL RISK AND FEAR OF FALLING OF OLDER ADULTS: THE MEDIATING AND MODERATING IMPACT OF HEALTH LITERACY
Authors: Kim Dahee , Thiamwong Ladda , Emrich Christopher , Li Yingru , Xie Rui 
Published: January 2025

Abstract
Objectives: Older adults who perceive more fall risks in their daily lives may have a higher fear of falling (FOF). Despite, as a human agency, health literacy of older adults may improve their health and well-being outcomes, but the role of health literacy in fall risk-FOF association has been less highlighted. This study investigated mediating and moderating impacts of their health literacy on the fall risk-FOF association. Methods. This study used data from 176 community-dwelling older adults (MeanAge = 74.49, SDAge = 7.16). Self-reported fall risk was measured using the CDC STEADI fall risk checklist. FOF was assessed using the Short Falls Efficacy Scale International. Health literacy was reported as the level of confidence in filling out a medical form by oneself. This study employed the SPSS PROCESS Macro to test the mediation and moderation models. Results. Older adults’ health literacy moderated their self-reported fall risk-FOF association. The more fall risks older adults perceive, the higher FOF the Low health literacy group showed, whereas the lower FOF the High health literacy group reported. This indicates that health literacy would buffer the impact of fall risk in daily life on FOF in late adulthood. However, we found no indirect impact of self-reported fall risk on FOF via health literacy. Conclusion. These findings highlight the role of health literacy in mitigating the impact of self-reported fall risk on FOF of older adults. This study suggests health literacy as an agency that enhances health and well-being in older adults’ remaining lives.
SENSOR-BASED MONITORING OF PHYSICAL ACTIVITY IN OLDER ADULTS SIX MONTHS POST-FALL: MODERATING FACTORS
Authors: Schmidt Laura , Stuckenschneider Tim , Kwiecien Robert , Zieschang Tania 
Published: January 2025

Abstract
Older individuals who have experienced a fall often experience concerns about falling, impaired activities of daily living, and reduced physical activity (PA). Changes in PA following a fall are often influenced by moderators such as age or fall history; however, these moderators remain understudied. Therefore, this project investigates the association between moderators and changes in PA in older adults after a fall. Participants aged ≥60 years were recruited if they presented to the emergency department following a fall without hospital admission. Moderators were collected through a home-based geriatric assessment conducted within four weeks after the fall. PA was measured within four weeks and six months after the fall using an accelerometer (activPAL4, PAL Technologies Ltd., UK). Associations between moderators and changes in PA were calculated fitting Linear Mixed Model (LMM) in R (R Core Team, 2023 Version 4.3.2 (2023-10-31). A total of 178 valid datasets were analyzed. LMM analysis revealed a significant average increase in step count over time (p=0.006). Notably, female participants showed a significant larger increase in steps per day (+1,777.9, 95% CI: 292.2 – 3263.7, p=0.019) than male participants. In women, fall history (95% CI: -1009.5 – (-207.4), p=0.003) and age (95% CI: -315.8 – (-82.5), p&lt; 0.01) were negatively associated with step counts. Given the healthcare challenges associated with falls in older adults, our findings underscore the importance of early identification of moderators in emergency department settings. Identifying these factors may enable targeted interventions for individuals at risk of functional decline post-fall, potentially preventing further functional decline.