bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects and Processes of an mHealth Intervention for the Management of Chronic Diseases: Prospective Observational Study
Authors: Breckner Amanda , Litke Nicola , Göbl Linda , Wiezorreck Lars , Miksch Antje , Szecsenyi Joachim , Wensing Michel , Weis Aline 
Published: June 2022

Background
Mobile health (mHealth) interventions for self-management are a promising way to meet the needs of patients with chronic diseases in primary care practices. Therefore, an mHealth intervention, TelePraCMan, was developed and evaluated for patients with type 2 diabetes mellitus, chronic obstructive pulmonary disease, high blood pressure, or heart failure in a German primary care setting. TelePraCMan entails a symptom diary, an appointment manager, a manager to document goals, and a warning system. The app should foster the self-management of participating patients.

Objective
We aimed to examine the effects of TelePraCMan on patient activation and quality of life and explored the underlying contextual factors, impacts, and degree of implementation.

Methods
In a prospective observational study design, we collected data by using interviews and written questionnaires from participating patients (intervention and control groups) and primary care workers (physicians and practice assistants). The primary outcomes of interest were patient-reported quality of life (12-Item Short Form Survey) and patient activation (patient activation measure). The quantitative analysis focused on differences between patients in the intervention and control groups, as well as before (T0) and after (T1) the intervention. Interviews were analyzed by using qualitative content analysis via MAXQDA (VERBI GmbH).

Results
At baseline, 25 patients and 24 primary care workers completed the questionnaire, and 18 patients and 21 primary care workers completed the follow-up survey. The patients were predominantly male and, on average, aged 64 (SD 11) years (T0). The primary care workers were mostly female (62%) and, on average, aged 47 (SD 10) years (T0). No differences were observed in the outcomes before and after the intervention or between the intervention and control groups. In the additional interviews, 4 patients and 11 primary care workers were included. The interviewees perceived that the intervention was useful for some patients. However, contextual factors and problems with implementation activities negatively affected the use of the app with patients. The main reasons for the low participation were the COVID-19 pandemic and the target group, which seemed to have less interest in mHealth; the interviewees attributed this to the older age of patients. However, the respondents felt that the app would be better accepted in 5 or 10 years.

Conclusions
Although the TelePraCMan app was rated as very good and important by the participants, few patients used it. The digital intervention was hardly implemented and had limited impact in the current setting of German primary care.

Trial Registration
German Clinical Trials Register DRKS00017320; https://tinyurl.com/4uwrzu85
Measurement of Vital Signs Using Lifelight Remote Photoplethysmography: Results of the VISION-D and VISION-V Observational Studies
Authors: Heiden Emily , Jones Tom , Brogaard Maczka Annika , Kapoor Melissa , Chauhan Milan , Wiffen Laura , Barham Helen , Holland Jeremy , Saxena Manish , Wegerif Simon , Brown Thomas , Lomax Mitch , Massey Heather , Rostami Shahin , Pearce Laurence , Chauhan Anoop 
Published: June 2022

Background
The detection of early changes in vital signs (VSs) enables timely intervention; however, the measurement of VSs requires hands-on technical expertise and is often time-consuming. The contactless measurement of VSs is beneficial to prevent infection, such as during the COVID-19 pandemic. Lifelight is a novel software being developed to measure VSs by remote photoplethysmography based on video captures of the face via the integral camera on mobile phones and tablets. We report two early studies in the development of Lifelight.

Objective
The objective of the Vital Sign Comparison Between Lifelight and Standard of Care: Development (VISION-D) study (NCT04763746) was to measure respiratory rate (RR), pulse rate (PR), and blood pressure (BP) simultaneously by using the current standard of care manual methods and the Lifelight software to iteratively refine the software algorithms. The objective of the Vital Sign Comparison Between Lifelight and Standard of Care: Validation (VISION-V) study (NCT03998098) was to validate the use of Lifelight software to accurately measure VSs.

Methods
BP, PR, and RR were measured simultaneously using Lifelight, a sphygmomanometer (BP and PR), and the manual counting of RR. Accuracy performance targets for each VS were defined from a systematic literature review of the performance of state-of-the-art VSs technologies.

Results
The VISION-D data set (17,233 measurements from 8585 participants) met the accuracy targets for RR (mean error 0.3, SD 3.6 vs target mean error 2.3, SD 5.0; n=7462), PR (mean error 0.3, SD 4.0 vs mean error 2.2, SD 9.2; n=10,214), and diastolic BP (mean error −0.4, SD 8.5 vs mean error 5.5, SD 8.9; n=8951); for systolic BP, the mean error target was met but not the SD (mean error 3.5, SD 16.8 vs mean error 6.7, SD 15.3; n=9233). Fitzpatrick skin type did not affect accuracy. The VISION-V data set (679 measurements from 127 participants) met all the standards: mean error −0.1, SD 3.4 for RR; mean error 1.4, SD 3.8 for PR; mean error 2.8, SD 14.5 for systolic BP; and mean error −0.3, SD 7.0 for diastolic BP.

Conclusions
At this early stage in development, Lifelight demonstrates sufficient accuracy in the measurement of VSs to support certification for a Level 1 Conformité Européenne mark. As the use of Lifelight does not require specific training or equipment, the software is potentially useful for the contactless measurement of VSs by nonclinical staff in residential and home care settings. Work is continuing to enhance data collection and processing to achieve the robustness and accuracy required for routine clinical use.

International Registered Report Identifier (IRRID)
RR2-10.2196/14326
Determining the Influencing Factors on Acceptance of eHealth Pain Management Interventions Among Patients With Chronic Pain Using the Unified Theory of Acceptance and Use of Technology: Cross-sectional Study
Authors: Stoppok Paula , Teufel Martin , Jahre Lisa , Rometsch Caroline , Müßgens Diana , Bingel Ulrike , Skoda Eva-Maria , Bäuerle Alexander 
Published: June 2022

Background
Chronic pain is a complex disease with high prevalence rates, and many individuals who are affected do not receive adequate treatment. As a complement to conventional therapies, eHealth interventions could provide many benefits to a multimodal treatment approach for patients with chronic pain, whereby future use is associated with the acceptance of these interventions.

Objective
This study aims to assess the acceptance of eHealth pain management interventions among patients with chronic pain and identify the influencing factors on acceptance. A further objective of the study is to evaluate the viability of the Unified Theory of Acceptance and Use of Technology (UTAUT) model and compare it with its extended version in terms of explained variance of acceptance.

Methods
We performed a cross-sectional web-based study. In total, 307 participants with chronic pain, as defined according to the International Association for the Study of Pain criteria, were recruited through flyers, posters, and web-based inquiries between December 2020 and July 2021. In addition to sociodemographic and medical data, the assessment included validated psychometric instruments and an extended version of the well-established UTAUT model. For statistical analyses, group comparisons and multiple hierarchical regression analyses were performed.

Results
The acceptance of eHealth pain management interventions among patients with chronic pain was overall moderate to high (mean 3.67, SD 0.89). There was significant difference in acceptance among age groups (W=9674.0; r=0.156; P=.04). Effort expectancy (β=.37; P<.001), performance expectancy (β=.33; P<.001), and social influence (β=.34; P<.001) proved to be the most important predictors of acceptance. The extended UTAUT (including the original UTAUT factors as well as sociodemographic, medical, and eHealth-related factors) model explained 66.4% of the variance in acceptance, thus supporting the viability of the model. Compared with the original UTAUT model (performance expectancy, effort expectancy, and social influence), the extended model explained significantly more variance (F25,278=1.74; P=.02).

Conclusions
Given the association between acceptance and future use, the knowledge of the influencing factors on acceptance should be used in the development and promotion of eHealth pain management interventions. Overall, the acceptance of eHealth pain management interventions was moderate to high. In total, 8 predictors proved to be significant predictors of acceptance. The UTAUT model is a valuable instrument for determining acceptance as well as the factors that influence acceptance of eHealth pain management interventions among patients with chronic pain. The extended UTAUT model provided the greatest predictive value for acceptance.
Instructor Development Workshops for Advanced Life Support Training Courses Held in a Fully Virtual Space: Observational Study
Authors: Kiyozumi Tetsuro , Ishigami Norio , Tatsushima Daisuke , Araki Yoshiyuki , Yoshimura Yuya , Saitoh Daizoh 
Published: June 2022

Background
Various face-to-face training opportunities have been lost due to the COVID-19 pandemic. Instructor development workshops for advanced resuscitation (ie, advanced life support) training courses are no exception. Virtual reality (VR) is an attractive strategy for remote training. However, to our knowledge, there are no reports of resuscitation instructor training programs being held in a virtual space.

Objective
This study aimed to investigate the learning effects of an instructor development workshop that was conducted in a virtual space.

Methods
In this observational study, we created a virtual workshop space by using NEUTRANS (Synamon Inc)—a commercial VR collaboration service. The instructor development workshop for the advanced life support training course was held in a virtual space (ie, termed the VR course) as a certified workshop by the Japanese Association of Acute Medicine. We asked 13 instructor candidates (students) who participated in the VR course to provide a workshop report (VR group). Reports from a previously held face-to-face workshop (ie, the face-to-face course and group) were likewise prepared for comparison. A total of 5 certified instructor trainers viewed and scored the reports on a 5-point Likert scale.

Results
All students completed the VR course without any problems and received certificates of completion. The scores for the VR group and the face-to-face group did not differ at the level of statistical significance (median 3.8, IQR 3.8-4.0 and median 4.2, IQR 3.9-4.2, respectively; P=.41).

Conclusions
We successfully conducted an instructor development workshop in a virtual space. The degree of learning in the virtual workshop was the same as that in the face-to-face workshop.
The functional role of miRNAs in inflammatory pathways associated with intestinal epithelial tight junction barrier regulation in IBD
Authors: Ochman Błażej , Kula Agnieszka , Świętochowska Elżbieta 
Published: June 2022

Abstract
Inflammatory bowel disease – Crohn's disease and ulcerative colitis – is an immune-mediated chronic disorder with still not fully elucidated complex mechanisms of pathogenesis and pathophysiology. Intestinal epithelial barrier (IEB) dysregulation is one of the major underlying mechanisms of inflammatory process induction in IBD. Proper IEB integrity is maintained to a large extent by intercellular tight junctions, the function of which can be modified by many molecules, including miRNAs. MiRNAs belong to noncoding and non-messenger RNAs, which can modulate gene expression by binding predicted mRNAs.
In this review, we summarize and discuss the potential role of miRNAs in the regulation of inflammatory signaling pathways affecting the function of the intestinal epithelial barrier in IBD, with particular emphasis on therapeutic potentials. The aim of the review is also to determine the further development directions of the studies on miRNA in the modulation of the intestinal epithelial barrier in IBD.
TGF-β signaling in diabetic nephropathy: An update
Authors: Wang Li , Wang Hong-lian , Lan Hui-yao 
Published: June 2022

Abstract
Diabetic nephropathy (DN) is a common complication in patients with diabetes and the leading cause of end-stage renal disease. Accumulating evidence shows that transforming growth factor beta-1 (TGF-β1) is a key mediator in the pathogenesis of DN. TGF-β1 binds to its receptors to activate canonical and noncanonical downstream signaling pathways to exert its biological activities. Among them, canonical Smad signaling is the major pathway responsible for the development of DN. In addition to TGF-β1, many stress molecules, such as advanced glycation end products (AGEs), angiotensin II (Ang II), and C-reactive protein (CRP), can also activate Mothers against decapentaplegic homologs (Smads) via the extracellular signal-regulated kinase (ERK)/p38 mitogen-activated protein kinase (MAPK) cross talk mechanism. Furthermore, TGF-β/Smad signaling can also cross talk with nuclear factor kappa B (NF-κB) signaling to regulate renal inflammation via the induction of IκBα by Smad7. In the context of renal fibrosis, Smad3 is pathogenic, while Smad2 and Smad7 are protective. TGF-β signaling also upregulates the pathogenic microRNAs (miRNAs) (namely, miR-21, miR-192, and miR-377) and long noncoding RNAs (lncRNAs) (namely, Erbb4-IR (intron region, IR), LncRNA9884, and Arid2-IR) but downregulates the protective miRNAs (namely, miR-29a/b and miR-200a) to mediate DN. Thus, targeting TGF-β signaling, either by blocking its ligand, its receptor (i.e., TGF-β receptor-2 [TGFBR2]), Smad3, and downstream miRNAs/lncRNAs or by overexpressing Smad7, has been shown to improve DN. In addition, pharmaceutically targeting TGF-β signaling using chemical inhibitors and traditional Chinese medicine (TCM), including Tangshen formula, Chaihuang-Yishen granule, and herbal extracts (berberine, asiatic acid, and naringenin), also shows renoprotective effect in diabetes. In summary, TGF-β signaling is a critical pathway leading to DN and may be a therapeutic target for combating DN.
Eating, drinking and travelling for fun. Backward to ‘Tourism and Gastronomy’ and forward to the Covidocene
Authors: Marques da Silva António José 
Published: June 2022

Abstract

Tourism and Gastronomy (T&G) was published in 2002. Even today, this book is an indispensable reference for researchers from different disciplinary perspectives who study how food and beverage are linked to leisure mobility. At that time, the contributors witnessed a major shift in consumer behaviour, which would soon turn the act of eating and drinking into a first-order driver of this sector of activity. The objective of the editors was to map the evolution of this new trend and predict the future of gastronomy and culinary heritage in tourism. This paper will revisit T&G to fully understand how, in only twenty years, what was before just a ‘non-optional’ part of the package became a prosperous niche, and later a primary component of recreational travels. The ‘throw-back’ approach adopted here will enable us to reflect on how the COVID-19 crisis impacts holidaymakers’ choices, which could help in the design of more efficient recovery plans.
Efficient way to ensure the data security in cloud computing
Authors: Pallikonda Anil Kumar , Chaduvula Kavitha , Markapudi Baburao , Jyothi Ch Rathna , Indira D N V S L S 
Published: June 2022

Abstract
This manuscript proposes a cloud data storage security, which has always been an important aspect of Quality of Service (QOS). Here, an effectual and flexible distributed scheme (DS) with Explicit Dynamic Data Support (EDDS) is proposed to ensure the accuracy of user data in the cloud. By using hemimorphic token with distributed verification of erasure-coded data, the proposed scheme achieves the integration of storage correctness insurance and data error localization. The proposed scheme supports secure and efficient dynamic operations on data blocks, such as data update, delete and append. The performance analysis shows that the proposed scheme is highly efficient.
ALIH KODE DAN CAMPUR KODE PADA IKLAN DI AKUN INSTAGRAM CARUBANID
Authors: Dewi Dyah Ayu Resita , Soleh Dwi Rohman , Puspitasari Dhika 
Published: June 2022

<p>Penelitian ini bertujuan untuk mendeskripsikan alih kode dan campur kode pada iklan di akun instagram <em>CarubanID </em>dan mendeskripsikan faktor-faktor penyebab terjadinya alih kode dan campur kode pada iklan di akun instagram <em>CarubanID</em>. Penelitian ini dilaksanakan selama 5 bulan, mulai bulan Februari sampai dengan bulan Juni 2019, dimulai dengan mencari data sampai dengan menulis laporan. Penelitian ini menggunakan metode penelitian kualitatif. Data penelitian ini didapat dari hasil melihat kenyataan sesungguhnya yang berupa tulisan-tulisan, lalu dianalisis dan ditafsirkan dengan objektif untuk kemudian dideskripsikan dalam bentuk kata-kata dan bahasa. Data berupa alih kode dan campur kode pada iklan di akun instagram <em>CarubanID</em>. Peneliti mengumpulkan sebanyak-banyaknya iklan yang kemudian terkumpul sebanyak 52 iklan. Pengumpulan data dilakukan dengan penelaahan terhadap dokumen tertulis. Hasil penelitian ini menunjukkan bahwa terdapat 33 data alih kode dan 50 data campur kode. Dari 33 data terdapat 4 bentuk alih kode yaitu, alih kode dari bahasa Inggris ke bahasa Indonesia, alih kode dari bahasa Indonesia ke bahasa Inggris, alih kode dari bahasa Indonesia ke bahasa Jawa, dan alih kode dari bahasa Jawa ke bahasa Indonesia. Dari 50 data terdapat 3 bentuk campur kode yaitu, campur kode bahasa Indonesia dan bahasa Inggris, campur kode bahasa Indonesia dan bahasa Jawa, dan campur kode bahasa Indonesia, bahasa Inggris, dan bahasa Jawa. Faktor-faktor penyebab terjadinya alih kode dan campur kode pada iklan di akun instagram <em>CarubanID </em>ada 4 yaitu, karakter bisnis dari pembuat iklan, teknis penulisan terpengaruh oleh bahasa lisan, kurangnya penguasaan bahasa yang akan digunakan, dan adanya bahasa serapan.</p>
ANALISIS ASPEK GRAMATIKAL DAN LEKSIKAL PADA CERPEN “FILOSOFI KOPI” KARYA DEE LESTARI
Authors: Rohmawati Nurvita , Suharto Teguh , Meikayanti Ermi Adriani 
Published: June 2022

<p>Cerpen Filosofi Kopi Karya Dee Lestari ditemukan banyak aspek gramatikal dan leksikal. Untuk itulah, penelitian ini bertujuan untuk mendeskripsikan penggunaan aspek gramatikal dan leksikal pada Cerpen Filosofi Kopi Karya Dee Lestari. Penelitian ini termasuk jenis penelitian deskriptif kualitatif. Waktu penelitian selama 4 bulan, mulai Maret sampai Juni 2019. Sumber data penelitian menggunakan sumber data sekunder berupa cerpen. Instrumen penelitian berbentuk dokumen yaitu berupa cerpen. Pengumpulan data menggunakan teknik dokumentasi. Teknik analisis data menggunakan analisis isi. Prosedur penelitian berupa persiapan yaitu mencari referensi, pelaksanaan yaitu menganalisis arsip, dan tahap penyelesaian yaitu simpulan. Berdasarkan analisis aspek gramatikal ditemukan ada tiga bentuk yaitu referensi (pengacuan), subtitusi (penyulihan), dan konjungsi (penghubung). Referensi dari data yang ditemukan terdapat aku, kami, malam itu, dan bagai. Subtitusi yang ditemukan diganti dengan kata mereka dan dia. Konjungsi terdapat ada kata hubung karena, hingga, atau dan tetapi. Hasil analisis aspek leksikal ditemukan enam bentuk yaitu repetisi, sinonimi, kolokasi, hiponimi, antonimi, dan ekuivalensi. Repetisi berupa pengulangan kata buku, 50 Juta, dan minuman itu. Sinonimi ditemukan data berupa persamaan kata menyelinap, menyusup, dan cemas. Kolokasi ditemukan data berupa kata yang berdampingan yaitu golongan jaringan pembuatan kopi. Hiponimi ditemukan data berupa hubungan atas bawah yang maknanya pada lingual lainnya yaitu macam-macam kopi. Antonimi ditemukan data berupa lawan kata lugu, datang, dan sempurna. Ekuivalensi ditemukan data berupa proses afiksasi dari kata dasar bentuk, tanam, dan sindir.</p>
IMPLEMENTASI METODE PEMBELAJARAN SUGESTOPEDIA DAN TOTAL PHYSICAL RESPONSE (TPR) UNTUK MENGEMBANGKAN KEMAMPUAN BERBICARA SISWA PAUD
Authors: Suryantini Nunik , Cahyono Bambang Eko Hari , Ricahyono Sigit 
Published: June 2022

Penelitian ini bertujuan untuk mendiskripsikan dan menjelaskan implementasi metode pembelajaran sugestopedia dan Total Physical Response (TPR) untuk mengembangkan kemampuan berbicara siswa PAUD. Penelitian ini merupakan penelitian deskriptif kualitatif. Subjek dari penelitian ini adalah siswa usia 4-5 tahun PAUD Joy Kota Madiun. Teknik yang digunakan dalam penelitian ini adalah observasi, wawancara, dan dokumentasi. Hasil penelitian menunjukkan bahwa metode suggestopedia dan total physical response TPR adalah metode yang tepat digunakan dalam pembelajaran di masa pandemi covid 19, maka diharapkan agar dikembangkan implementasinya pada kelompok usia yang berbeda dan aspek perkembangan anak yang lain.