bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison of the molecular profiling of core biopsy with surgical specimens in breast cancers and the effect of neoadjuvant therapy on the same – A North Indian study
Authors: Verma Priyanka , Sharma Neelam , Gulati Anchana , Sharma Reetika , Parashar Anupam , Kaundal Ashok 
Published: August 2022

ABSTRACT

Aims and Objectives:
The purpose of this study was to determine the concordance of core needle biopsy (CNB) and surgical specimens for determining the molecular profiling and to observe the changes in the same after neoadjuvant chemotherapy.

Materials and Methods:
This was a cross-sectional study over a period of one year on 95 cases. Immunohistochemical (IHC) staining was done as per the staining protocol in a fully automated BioGenex Xmatrx staining machine.

Results:
On CNB, estrogen receptor (ER) positivity was seen in 58 out of 95 cases, comprising 61% of the total, and on mastectomy, it was positive in 43 (45%) cases. Progesterone receptor (PR) positivity was seen in 59 (62%) cases on CNB and 44 (46%) cases on mastectomy. Total 7 (7%) were human epidermal growth factor receptor 2 (HER2)/neu positive on CNB and 8 (8%) on mastectomy, respectively. There were 15 (15.7%) that showed discordant results after neoadjuvant therapy. Estrogen status changed from negative to positive in 1 (7%) case and positive to negative in 14 (93%) cases. Progesterone status changed from positive to negative in all 15 cases (100%). There was no change in the HER2/neu status. The agreement of hormone receptor status between CNB and subsequent mastectomy in the present study was found to be substantial (kappa value for ER, PR, and HER2neu as 0.608, 0.648, and 0.648, respectively.

Conclusion:
IHC is a cost-effective method to assess hormone receptor expression. This study shows that ER, PR, and HER2/neu expression in CNB should be reassessed in excision specimens for the better management of endocrine therapy.
To compare neoadjuvant concurrent chemo-radiotherapy followed by surgery and neoadjuvant chemotherapy followed by surgery in carcinoma esophagus patients: A single institutional study in the Indian population
Authors: Purkayastha Abhishek , Sharma Neelam , Sundaram Viswanath , Jaiswal Pradeep , Husain Azhar 
Published: August 2022

ABSTRACT

Objective:
This single institutional study compared neoadjuvant concurrent chemo-radiotherapy (NACCRT) and neoadjuvant chemotherapy (NACT) followed by surgery in locally advanced middle and lower-1/3 carcinoma esophagus patients in terms of toxicity, clinical response, operative complications, disease downstaging, resection rates, pathological response, recurrence, and survival.

Materials and Methods:
This randomized prospective comparative study comprised 40 consecutive patients divided equally between two study arms NACCRT (n = 20; 41.4 Gy radiation dose; carboplatin area under the curve (AUC) 2/paclitaxel 50 mg/m2; 5 cycles) and NACT (n = 20; carboplatin AUC 5/paclitaxel 175 mg/m2; 2 cycles) from March 2014 to December 2016. Follow-up was done for 4 years. Chi-square test, Fischer’s-exact test were used for comparative analysis and Kaplan-Meier analysis for survival.

Results:
Statistically significant esophagitis in NACCRT and peripheral-neuropathy in NACT was observed (P < 0.001). NACCRT recorded more postoperative complications, higher complete resection (R0) rates, and pathologically complete response (pCR). Tumor downstaging was significant in both study groups (n < 0.001). Four-year median disease-free survival (DFS) and overall survival (OS) were 28.50 months and 38 months in NACCRT versus 28 months and 35.5 months in NACT, respectively. In both NACCRT and NACT, pCR cases showed improved median DFS and OS compared to pathological partial response (pPR) (n < 0.001).

Conclusion:
This study demonstrated significant activity and tolerable toxicity of taxane-based therapy in NACCRT and NACT. Both groups recorded no survival benefit over each other, although pCR cases resulted in statistically significant survival advantage compared to clinical partial response. NACCRT resulted in lesser toxicity, numerically higher R0-resection, pCRs, median DFS, and OS compared to NACT.
The Indian Academy of Cytologists Guidelines for Reporting Serous Effusion (IACGRSE)
Authors: Nagose Vaishali B. , Kamal Meharbano M. , Kathuria Surbhi S. , Laddhad Shraddha A. 
Published: August 2022

Context:
The Indian Academy of Cytologists published Guidelines and categories for Reporting Serous Effusions (IACGRSE) in 2020 to improve consistency and reproducibility of fluid cytology reporting and to guide patient management.

Aims:
To evaluate category-wise agreement while using IACGRSE 2020 categories. To analyze interobserver agreement among participants with different level of training and years of experience.

Settings and Design:
A retrospective interobserver variability study.

Methods and Material:
Study was done with four participants: an expert cytopathologist and three cytopathology fellows with varying experience. Fluid smears from 60 cases with clinical and/or radiological evidence of malignancy were categorized into one of the five IACGRSE 2020 categories. The interpretations of expert cytopathologist were taken as standard.

Statistical Analysis Used:
Interobserver agreement was analyzed using Kappa statistics.

Results:
Previous cases without definitive category got classified into “Atypical cells NOS” (3.33%) and “Atypical cells, Suspicious of Malignancy” (15%). Agreement analysis for IACGRSE 2020 categories showed better concordance for inadequate (I), malignant (V), and benign (II) categories. The range of Kappa for interobserver agreement of fellows was fair to substantial (range 0.1692–0.7249). The participant with substantial diagnostic agreement with expert (κ = 0.729, 88.3%) had the most experience. Causes of major discordance were pertaining to paucity and distribution of cells, and to misinterpretation of reactive mesothelial cells.

Conclusions:
IACGRSE 2020 categories and participants’ experience were important determinants in classifying the effusion fluid cytology smears and interobserver agreement; emphasizing the need to use IACGRSE2020, and sufficient time and training required for accurate diagnosis of fluid specimens.
CSF Involvement by Nonhematolymphoid Malignancies
Authors: Balasubramaniam Vidhya Vikashini , Mohan Saranya , Reddy Suganya Kuppovi , Rekha Jinkala Sree , Gochhait Debasis , Siddaraju Neelaiah 
Published: August 2022

Introduction:
Detection of malignant cells in cerebrospinal fluid (CSF) samples in suspected cases of malignancy is critical for the management of patients. CSF involvement by nonhaematolymphoid malignancies is less common. We aimed to study the cytomorphologic characteristics of various nonhaematolymphoid malignancies in CSF.

Methods:
A retrospective cytomorphological analysis of 27 CSF cytology smears reported as positive or suspicious for nonhematolymphoid malignancies from January 2010 to April 2020 over 10 years was carried out. Smears in all cases were prepared by cytospin technique and stained with May-Grunwald-Giemsa (MGG) and papanicolaou (Pap) staining procedures. Cell immunohistochemistry/immunocytochemistry was done wherever cell block/extra slides were available.

Results:
Twenty-four of 27 cases were interpreted as “positive,” while three were reported as “suspicious” of malignancy. Nineteen of 27 cases were metastatic adenocarcinomas including three suspicious malignancy cases with the primary sites of origin being the breast (10), stomach (2), rectum (1), gall bladder (1), lung (1), and four cases of unknown primary. Of the remaining positive cases, there were five cases of metastatic medulloblastoma, two cases of metastatic pineoblastomas, and one case of metastatic extraskeletal Ewings sarcoma. Each of these metastatic malignancies had at least a single diagnostic cytomorphological clue, similar to those observed in other body cavities and primary malignancy sites.

Conclusion:
Nonhematolymphoid malignancies are readily diagnosable on CSF cytology, most of them are metastatic. Identification of malignant cells in CSF is critical, as it has therapeutic and prognostic implications.
Diagnostic Accuracy and Agreement Between Inter- and Intra-Observers in the Absence of Clinical History for Liquid-Based Preparation of Gynecology Specimens
Authors: Roslan Nur Amirah , Abu Mohd Nazri , Ismail Farid Ridhuan 
Published: August 2022

Context:
The clinical history in cytology is the best source of information to ensure the accuracy of diagnosis, facilitating a slide observer to interpret and relate their findings in screening gynecology slides.

Aims:
This study aims to evaluate the performance of slide observers to screen-blinded gynecology slides without providing any information on clinical history.

Setting and Design:
A correlational study design was conducted at the cytology laboratory, Universiti Teknologi MARA Selangor, Puncak Alam Campus.

Methods and Materials:
Fity-seven liquid-based preparation slides from gynecology specimens were screened blindly by five slide observers among Medical Laboratory Technology students who completed the enrollment of the cytology course.

Statistical Analysis Used:
The inter- and intra-observer reliability testing was measured using the kappa value of Fleiss’ and Cohen's kappa value, respectively, while the diagnostic accuracy without a clinical history was determined by the receiver operating characteristic (ROC) curve.

Results:
The value of Fleiss’ kappa (κ) was 0.221—this represents a fair strength of agreement between inter-observers. An intra-observer reliability test for each slide observer was analyzed using Cohen's kappa statistic and revealed that the kappa value varied between 0.116 and 0.696, indicating slight-to-substantial agreement between intra-observers. Additionally, the sensitivity value of 94.28%, specificity value of 72.40%, a positive predictive value (PPV) of 37.28%, a negative predictive value (NPV) of 72.40%, a likelihood ratio of 14.43, and the diagnostic accuracy of 75.09% were recorded.

Conclusions:
In conclusion, the students (slide observers) from the Centre of Medical Laboratory Technology Studies who took part in this study were able to interpret, classify, and diagnose the LBP gynecologic cytopathological cases into several categories (NILM and ECA) based on the 2001 Bethesda System reporting guideline.
Clinical and Imaging Manifestations of Pediatric Melioidosis in Hainan, China
Authors: Fan Long , Wu Yehua , Mai Shengshi , Lu Hong , Zhan Yuefu 
Published: August 2022

OBJECTIVE:
The objective of this study was to investigate the clinical and imaging manifestations of melioidosis in children in Hainan Province, China, to improve its understanding.

MATERIALS AND METHODS:
We retrospectively analyzed 10 children with melioidosis in Hainan Province, China, from January 2002 to November 2021. We collected clinical and imaging data. These data were analyzed retrospectively by two radiologists with more than 10 years' radiology imaging experience.

RESULTS:
The patients' average age was 8.4 years (range: 17 days to 15 years), the male-to-female ratio was 6:4, and the average length of hospital stay was 31.5 days (5–96 days). Only two patients had underlying diseases, which were acute lymphocytic leukocyte hepatitis and hepatitis B. One patient had no onset of fever, and the other nine patients had a fever, with an average temperature of 39.5°C (38.4–40.3°C). Two patients had a low white blood cell count (0.27 × 109/L, 3.6 × 109/L), four had a normal white blood cell count, and two had a slightly high white blood cell count (13.6 × 109/L, 14.2 × 109/L). Two patients aged <1 year had a high white blood cell count >34 × 109/L and died. One patient was automatically discharged from the hospital and stopped treatment because of economic factors, and the rest improved after treatment. The neutrophil count was normal in two patients, but it was increased in the other patients. There were no data of C-reactive protein (CRP) measurements in three patients, and four of the other seven patients showed greatly elevated CRP concentrations. Among these four patients, two died and two were cured. One patient had sepsis, three had septicopyemia, and two had multiple organ dysfunction syndrome; among these six patients, one died and others improved. Four patients with pneumonia showed scattered exudation, consolidation, and nodules in both lungs, which developed into lung abscesses, as well as melioidosis and mumps. Three patients showed parotid swelling and abscess formation multilocular. One patient had liver and splenic abscesses. One patient had neck abscesses and one had perineal skin abscesses. One patient had purulent meningitis (clinical diagnosis) and disseminated intravascular coagulation (DIC), and this patient died.

CONCLUSIONS:
For patients in endemic areas, and those who have clinical manifestations of sepsis, pneumonia, mumps, and liver and splenic abscesses on imaging manifestations, the possibility of melioidosis should be considered. Microbial culture should be carried out as soon as possible, and these results of culture should be considered. Antibiotic treatment should be performed before a diagnosis. Mortality is more likely in patients who are aged <1 year and have considerably elevated CRP concentrations, multiple organ dysfunction syndrome, and central nervous system infection/DIC.
Editorial
Authors: Campos Mavare Mercedes Moraima 
Published: August 2022

La segunda edición de EDUCARE es la producción volumen 26 número ordinario del año 2022, año donde arriba al 25 aniversario y el cual es reflejo fiel del transitar académico vinculado con el quehacer investigativo propio de docentes comprometidos con el aporte al conocimiento y darlo a conocer mediante contribuciones con suficiente significancia en el contexto educativo. Este número viajará por latitudes remotas desde nuestro ámbito, pero cercano en lo que respecta al compromiso de dichos contribuyentes en la temática de cada artículo que recogen argumentaciones y posiciones propias de la ciencia que nos acobija.
Para nosotros, los responsables de la producción y divulgación son importante el arribo a este XXV aniversario de EDUCARE, porque ello nos permite esgrimir la continuidad de trabajo productivo de la misma, así como la observancia de la evolución que ha tenido en el tiempo sostenido y el camino que ha recorrido desde sus inicios hasta los actuales momentos. Estar hoy en día en plataformas que nos hacen mucho más visibles y cumplir los estándares que las mismas exigen, demuestra el logro de criterios de calidad. Es de reseñar que el cuerpo editorial ha tomado como norte la excelencia y la calidad de cada contribución a fin de conservar la acreditación obtenida en los índices nacionales e internacionales.
Development of an application to anonymize data to be shared in the cloud
Authors: Marrón David González , Ramírez Verónica Paola Corona , González Angélica Enciso , Callejas Alejandro Márquez , Hernández Iridian Sandivel Pérez 
Published: August 2022

A design of an interface is proposed to be developed as a lightweight application that allows the use of different algorithms to anonymize proposed by various authors, the application focuses on adapting data from distributed applications that must interact using the JSON lightweight Data Interchange Format. The user interaction is minimized for the anonymization process, an interface is provided to facilitate the selection process of the anonymization algorithms that users choose.
Las Retromemorias y antifaces textuales en las narrativas autobiográficas de Rosario Castellanos y Tununa Mercado
Authors: Ippolito Fiordaliza 
Published: August 2022

Narrar una autobiografía desde la narrativa de la infancia hace que la autobiografía retroceda a un pasado y buscar momentos específicos de nuestras vidas que marque momentos históricos. Esas memorias yo llamo retromemorias ya que ese pasado regresa con otro rostro textual en los que los recuerdos se mezclan con las memorias y aparecen ciertos silencios, pues desde allí existen huecos en el que el autor debe recorrer muchas veces a la ficción para poder llenar ciertos vacíos que se presentan en los espacios autobiográficos. Las voces narrativas de Rosario Castellanos en Balún Canán (2007) y La Madriguera (1996) de Tununa Mercado forman conscientemente el otro yo desde sus perspectivas narrativas al regresar al presente y contar sus vidas desde la mirada de una niña para así jugar con la noción entre, pasado y presente y entre inocencia y realidad. Este trabajo tiene como propósito analizar el dominio de las memorias autobiográficas desde la subjetividad desde la mirada de un yo que habla desde su infancia, analizaremos la novela de Rosario Castellanos en Balún Canán y La Madriguera de Tununa Mercado, exploraremos el lenguaje y las técnicas narrativas de la autobiografía en cada una de ellas. Examinaremos el doble papel del yo, el yo que habla y el yo que escribe, el yo público y el yo privado. Analizaremos las temáticas dentro de las novelas y sus personajes que se entornan en un mensaje político y social en cada una de ellas.
The effect of a novel toothpaste in children with white spot lesions
Authors: Yilmaz Muesser Ahu , Kulan Yildiz Pinar , Gokkaya Berna , Ozsalih Bilsel Seda , Kargul Betul , Admin  
Published: August 2022

Abstract
Objective: To investigate the effect of a novel mineral containing toothpaste in comparison to a fluoride toothpaste in children with white spot lesions.
Method: The clinical study was conducted from 2016 to 2018 at Marmara University Department of Pediatric Dentistry Clinic after approval from the ethics review committee of Yeditepe University, Istanbul, Turkey, and comprised children of either gender aged 4-5 years having white spot lesions. They were randomly allocated into two groups. The FT ( Fluoridated Toothpaste ) group was given a 500ppm fluoridated toothpaste, while the Mineral Containing Toothpaste (MCT) group was given toothpaste containing calcium glycerophosphate, magnesium chloride, and 12% xylitol. The white spot lesions were examined using Laser Fluorescence (LF) at baseline and after a month of usage. The two readings were compared. Stimulated saliva was collected for measuring the salivary potential of hydrogen, buffering capacity, and streptococcus mutans. Data was analysed using SPSS 19.
Results: Of the 26 children, 10(38%) were girls and 16(62%) were boys. The overall mean age was 4.77+/-0.54 years. There were 13(50%) subjects in each of the two groups. Of the 381 measurements done, 198(52%) were in the MCT group and 183(48%) in the FT group. LF scores decreased in both the groups (p=0.001). The remineralising potential was not significantly different (p=0.866), while salivary buffering capacity and potential of hydrogen increased in both the groups but the change was not significant (p>0.05). The number of children positive for streptococcus mutans decreased in both the groups (p>0.05).
---Continue
Real-Time Continuous Glucose Monitoring for People Living With Type 1 Diabetes
Authors: Barbara Angela M. , Grobelna Aleksandra 
Published: August 2022

Continuous glucose monitoring (CGM) is a method of glucose testing in which a sensor is inserted into the skin and continuously monitors interstitial glucose concentrations. Real-time continuous glucose monitoring (rtCGM) systems automatically measure glucose and display a recent glucose value.
Evidence suggests that rtCGM may improve hemoglobin A1C and time in range in adults and pediatric patients with type 1 diabetes, but this is uncertain.
Limited evidence suggests that in people with type 1 diabetes, there is little to no difference between rtCGM and self-monitoring of blood glucose (SMBG) on quality of life, diabetic ketoacidosis, and severe adverse events.
Safety evidence suggests that rtCGM may decrease severe hypoglycemia in adults and pediatric patients with type 1 diabetes, but this is uncertain.
rtCGM may be more cost-effective in the long term than SMBG in adults with type 1 diabetes.
Mapping photovoltaic power plants in China using Landsat, random forest, and Google Earth Engine
Authors: Zhang Xunhe , Xu Ming , Wang Shujian , Huang Yongkai , Xie Zunyi 
Published: August 2022

Abstract. Photovoltaic (PV) technology, an efficient solution for mitigating the impacts of climate change, has been increasingly used across the world to
replace fossil fuel power to minimize greenhouse gas emissions. With the world's highest cumulative and fastest built PV capacity, China needs to
assess the environmental and social impacts of these established PV power plants. However, a comprehensive map regarding the PV power plants' locations and extent remains scarce on the country scale. This study developed a workflow, combining machine learning and visual interpretation methods with big satellite data, to map PV power plants across China. We applied a pixel-based random forest (RF) model to classify the PV power plants from composite images in 2020 with a 30 m spatial resolution on the Google Earth Engine (GEE). The resulting classification map was further improved by a visual interpretation approach. Eventually, we established a map of PV power plants in China by 2020, covering a total area of 2917 km2. We found that most PV power plants were situated on cropland, followed by barren land and grassland, based on the derived national PV map. In addition, the installation of PV power plants has generally decreased the vegetation cover. This new dataset is expected to be conducive to policy management, environmental assessment, and further classification of PV power plants. The dataset of photovoltaic power plant distribution in China by 2020 is available to the public at https://doi.org/10.5281/zenodo.6849477 (Zhang et al., 2022).
Reactive Hyperplasias in the Oral Mucosa: Case Series
Authors: BAĞCI Nuray , PEKER İlkay , ÜÇOK Özlem 
Published: August 2022

Aim: Reactive hyperplasias are often encountered tumor-like exophytic lesions of the oral mucosa, but they are not a neoplasm. Local factors such as dental calculus, food residue stuck between teeth, incompatible prosthetic restoration, and systemic factors such as hormonal changes play a role in the etiology of these hyperplasia. The aim of this presentation is to evaluate the possible etiological factors, clinical, and radiological findings of 10 reactive hyperplasia cases seen in different regions of the mouth.
Case report: Ten patients (seven females and three males) with a mean age 40.2 applied to our clinic with complaints of swelling in the mouth. In the medical anamnesis, it was learned that three (30%) patients had recently given birth and the related swelling started to occur in the second trimester of pregnancy, three (30%) patients had different diseases such as heart, hypertension, diabetes, and cholesterol, and were under regular medication for systemic disease. There is no finding on extraoral examination. In intraoral examination, mass lesions which red and/or pink, lobular/nodular, painless, pedunculated and/or sessile, and smooth and/or ulcerated was seen on the maxilla of six patients, mandible of three patients, and lower lip mucosa of one patient. Poor oral hygiene in seven (70%) patients, prosthetic restoration in the lesion-related area in two (20%) patients, and attrition incisal tooth surface and diastema in one (10%) patient were found. Radiographic examination revealed that minimal resorption on the alveolar crest in the lesion-related area of only three (30%) patients was seen. All lesions were histopathologically examined after surgical excision. According to the clinic, radiographic and histopathological features, diagnosis of the lesions was made as pyogenic granuloma (four cases; 40%), peripheral ossifying fibroma (three cases; 30%), traumatic fibroma (two cases; 20%) and peripheral giant cell granuloma (one case; 10%).
Conclusion: It was concluded that the lesions examined in this case series were mostly caused by local factors. The clinical findings observed in the patients were red nodular mass, painless, soft, and smooth-surfaced. In the radiographic examination, no finding was detected in most of the lesions.