bluuebunny/crossref_metadata_2025_split huggingface dataset:
The COVID-19 pandemic and mental health outcomes – A cross-sectional study among health care workers in Coastal South India
Authors: T Rekha , Kumar Nithin , Hegde Kausthubh , Unnikrishnan Bhaskaran , Mithra Prasanna , Holla Ramesh , Bhagawan Darshan 
Published: June 2022

Background: Frontline health care workers (HCWs) are at increased risk of developing unfavourable mental health outcomes and burnout, especially during the COVID-19 pandemic. Recognizing the early warning signs of mental distress is very important to ensure the provision of quality patient care. Methods: In this facility-based cross-sectional study, HCWs of the teaching hospitals affiliated to Kasturba Medical College, Mangalore were assessed regarding their mental health status using a semi-structured questionnaire. All doctors and nurses who were willing to participate from these teaching hospitals were included in the study. Data was collected over a period of four months (1st March -30th June 2021) till the required sample size was reached and analysed using IBM SPSS and expressed using mean (standard deviation), median (interquartile range), and proportions. Univariate analysis was done to identify the factors associated with mental health outcomes among the HCWs and the corresponding unadjusted odds ratio and 95% confidence interval were reported. Results: A total of 245 HCWs [52.2% (n=128) doctors and 47.8% (n=117) nurses] were included in our study. The proportion of participants with depressive symptoms, anxiety, and insomnia assessed using PHQ-9, GAD-7, and ISI-7 scales were 49% (n=119), 38% (n=93), and 42% (n=102) respectively. Depression, anxiety, and insomnia were more likely to be experienced by HCWs aged > 27 years, females, and involved in COVID-19 patient care. (p>0.05) Conclusions: Our findings that 38% of the examined HCWs had clinically relevant anxiety symptoms and 49% had clinically relevant depression symptoms draws attention to the importance of systematically tracking the mental health of HCWs during this ongoing pandemic. HCWs should monitor their stress reactions and seek appropriate help both on a personal and professional level. Appropriate workplace interventions including psychological support should be provided to HCWs, to ensure provision of uncompromised quality patient care.
Maize seeds storage systems and post-harvest losses in Benin: diversity, efficiency, storage insects, and implications for better products conservation
Authors: Samba Gabin , Dassou Anicet G. , Idohou Rodrigue , Anagonou Corinne M. , Dansi Alexandre 
Published: June 2022

Background: Storage pests cause extensive damages to stored products and are responsible for huge post-harvest losses affecting the quality, quantity, and germination potential of stored grains and seeds. This study aimed to investigate the variability of traditional methods of storage and conservation of maize seeds practiced by farmers to propose alternative measures for a significant reduction of post-harvest losses of seeds. Methods : Using participatory research approaches, we surveyed farmers from 21 randomly selected villages in 5 districts in southern Benin. Data were collected on the storage structures of the 3 certified and most produced maize seeds varieties. The forms under which maize seeds are stored, as well as the damage caused by the major storage insects, were determined. Results: Results showed that most farmers store maize seeds in the form of grains and spathe. Following the laboratory observation of the three maize varieties studied, the DMR / QPM variety produced only in the district of Zagnanado has a low abundance of storage insects and a low rate of post-harvest losses. Sitophilus zeamais is the most abundant pest of the three maize seed varieties followed by Prostephanus truncatus. The variety 2000 SYN EE was the most attacked by storage insects. The most promising post-harvest agricultural practice is the storage of maize with spathe saved in jute bags, in granaries or cribs. Conclusions: Storage insects contribute to the depreciation of the quality of grains, loss of grain and reduction of their germinability in stock. Improving farmers' awareness of these post-harvest practices could help to reduce the damage of storage insects.
Numerical study of two heat exchangers for the cooling of a battery pack for an electric vehicle
Authors: Morel Christophe , Pra Franck , Pham Qyunh Trang , Fiette Sébastien , Larranaga Manex , Vertiz Gorka , Arrinda Mikel 
Published: June 2022

Background: The thermal management of a battery pack designed for an electric vehicle is a key to prevent accidental events and ensure a long lifespan of the batteries. A typical accident is a thermal runaway of one or more cells in the battery which can cause fire or explosion of the battery pack. This paper presents a numerical modelling of a battery pack (BP) and its heat exchanger (HE) for an electric vehicle. The heat produced in the battery is evacuated by the HE. Methods: Two different kinds of modelling have been realized: a computational fluid dynamic (CFD) modelling and a coarse (called MOD3 for 3D Model) modelling. The CFD modelling allows the creation of fine numerical simulations of a BP, but uses large meshes, therefore the cost of each calculation is important. In order to make a large number of quite long transient simulations, a second tool called MOD3, employing only a coarse mesh, was developed in this study at the Commissariat à l’énergie atomique et aux énergies alternatives (CEA). Results: Two measurement campaigns corresponding to two different versions of the HE have been conducted at CEA. The temperature measurements allow comparisons of MOD3 to a real battery pack and to fit some heat exchange coefficients. The cells temperatures as well as the cooling liquid temperature are compared. Conclusions: The MOD3 tool has been fitted partly on CFD calculations, and partly on experimental measurements. It will be integrated in a machine learning environment by CIDETEC to take into account the thermal management of the BP in real car simulations.
Editorial
Authors: Ruellas Eloísio Alexsandro Da Silva 
Published: June 2022

The concept of death as an entity has existed in many societies since the beginning of our history. From the 15th century onwards, with the revival of Greco-Roman culture as a source of artistic inspiration, it came to be represented by a skeletal figure carrying a scythe and dressed in a hooded black robe. This was inspired by Hades, the Greek god of the underworld, and by Thanatos, the personification of death, and is an image with strong negative connotations. The theme of death can be approached from several perspectives, including positive ones. Regardless of the angle from which it is viewed, certainly in these times of pandemic, we all think or deepen our thinking about death. But what happens to humanity afterwards? Can we become better people? A socially better humankind? Can we produce really justifiable and sustainable health science? Transformations have taken place, but some were just repetitions of history disguised as contemporary innovation. As epidemiological data show the decline of the Covid-19 pandemic, life seems to be returning to “normality” in the concept of being as it was before. For those who think like this, we must not forget that what prevailed before is what brought us to where we are now and, therefore, a translational historical rescue becomes essential for survival with quality of life for both humans and humanity. Hope is still inside Pandora's box. in memory of Professor Edna Ferreira da Cunha Eloísio Alexsandro da Silva RuellasEditor In-Chief
Covid-19 pandemic in the state of Piauí (Brazil): Reported cases, deaths and bed occupancy
Authors: Costa Filho Antonio A. I. , De Oliveira Naila A. , Próspero Deyna F. A. , Guimarães Mayla R. , Ibiapina Aline R. S. , Rabi José A. 
Published: June 2022

Introduction: This work describes the evolution over time of the Covid-19 pandemic in terms of reported cases, deaths and bed occupancy in the state of Piauí (Brazil) from 6 April 2020 to 4 January 2021. Objectives: The aim is to provide quantitative information on decision-making related to preventive measures and their effectiveness. Methodology and resources: Data were surveyed from the “Covid-19 in Piauí – Panel” to support a cross-sectional study that includes gender, age group, reported deaths, and bed occupancy as variables for built-in descriptive statistics and mobile mean estimates. Results and discussion: The data pointed to a slightly higher incidence (54.63%) in women, the highest (22.64%) being among patients in the range from 30-39 years. Recovery comprised 140,420 patients (97.48%) while confirmed deaths included 2,862 patients (1.99%), along with 774 (0.53%) sub-notifications. With respect to the latter, lethality was higher (58.56%) in men, reaching 77.67% in the case of those older than 60 years. In 2020, demands for either clinical or intensive care unit beds increased quickly during the first months of the pandemic, whereas demand for stabilization beds fluctuated intensely. Conclusion: Since a high prevalence (71.55%) was observed in economically active age groups and the highest lethality occurred among the elderly, preventive measures are still required and should be continuously adopted to mitigate the spread of Covid-19 in the state of Piauí (Brazil). Keywords: Public health; Epidemiological monitoring; 2019-nCoV pandemic.
Endostar plus pembrolizumab combined with a platinum-based dual chemotherapy regime for advanced pulmonary large-cell neuroendocrine carcinoma as a first-line treatment: A case report
Authors: Zhang Sijia , Xiao Yu , Chen Leichong , Li Zhenyu , Zong Yan , Zhu Kuikui , Meng Rui 
Published: June 2022

Abstract
Pulmonary large-cell neuroendocrine carcinoma (LCNEC) is a rare and highly aggressive cancer with a very poor prognosis. The proper treatment decision and possible prognosis outcome for advanced LCNEC is always an enormous challenge due to its scarcity. Here, we presented a 59-year-old male patient with advanced LCNEC with a non-neuroendocrine immunophenotype who received endostar plus pembrolizumab combined with a platinum-based dual chemotherapy regime as a first-line treatment. At present, the patient’s condition is well controlled by medication only and has a progression-free survival of more than 2 years. Adverse effects recorded for this patient during treatment courses include nausea, vomiting, II–III quality bone marrow toxicity, and PD-1 blockage-related hypothyroidism. This case report discussed the feasibility of immunotherapy, anti-angiogenesis agents, and chemotherapy as a first-line therapy in advanced LCNEC.
Modelling, design and parametric analysis of a levitation based energy harvester
Authors: Kogodu Thirthappa Prajwal , Krishnan Manickavasagam 
Published: June 2022

Abstract
Levitation based energy harvester (LBEH) is an energy harvesting technology which is used to convert the existing kinetic energy into electrical energy. The technique utilizes a levitating magnet which in a closed container vibrate or moves for the subjected vibrations. An outer coil which will extract energy into electrical voltage is carefully selected or designed or the rating. In this research work, a conventional LBEH is designed, simulated, and studied for a particular vibration data. The same is carried out in the FEM analysis software. The system is also mathematically derived and analyzed in the numerical tool. The results obtained from the numerical and FEM tool are compared. At the end of the research work, a parametric study is carried out for the variations in the input characteristics such as frequency, nature of vibrations and other parameters. Results obtained indicate that the power developed is maximum with a value of 0.7 V and 10 mW for the designed natural frequency of 10 Hz and decreases on either side as the bandwidth varies from 5 to 15 Hz.
Law and Technology in the US Law School Industry
Authors: Fish Jessica L. H. , Haskell John D. 
Published: June 2022

Abstract
Law schools are increasingly pressured to rethink the character of next generation research, policy impact and curricular training in the wake of computer-oriented technologies. For all its heralded importance and the proliferation of markets and talk around the topic of law and technology within the law school industry, there are still no systematic scholarly attempts to understand how these dynamics currently play out in practice for law schools, what such an investigation might tell us about the present and future composition of legal academia, or how one might begin in the first place to even identify, gather and make sense of data toward these ends. The purpose of this paper is two-fold: on the one hand, to analyse the methodological and theoretical challenges involved in this sort of blended empirical/qualitative study that might be applied to similar studies in any global context, and on the other hand, to draw out a clearer picture of the dynamics of organizational change in US law schools in relation to the phenomena of digital technologies – and all too often underexplored, to unpack some of the dynamics of culture, profession and wealth at play. In more vernacular terms, our aim here is to get a better sense of how and what we talk about when we talk about law and technology as legal academics.
L3 acquisition of aspect: the influence of structural similarity, analytic L2 and general L3 proficiency
Authors: Eibensteiner Lukas 
Published: June 2022

Abstract
Research has shown that many factors influence the transfer process in L3 acquisition (e.g., language distance, L2-status, proficiency in the L2/L3). Regarding the L2/L3 acquisition of aspect, a lot of research on the influence of the L1 has been conducted; however, to date, only a very limited amount of studies has analysed the influence an L2 exerts on the acquisition of aspect in an L3. The present study, therefore, focuses on L3 acquisition of perfective/imperfective aspect. We investigated 109 German-speaking learners of L3 Spanish with previous linguistic L2 knowledge in English. Data were elicited by means of a language background questionnaire, a c-test for overall proficiency measures in the L3, an oral retelling of two picture-based narratives, and two semantic interpretation tasks to measure the participants’ knowledge of aspect in the L2 and the L3 (i.e., analytic proficiency). The findings provide empirical evidence that L2 English positively influences the acquisition of aspect in L3 Spanish if structural similarities between the L2 and the L3 exist. However, positive L2 transfer seems to depend on L2 and L3 proficiency levels.
Interleukin-2 expands neuroprotective regulatory T cells in Parkinson’s disease
Authors: Markovic Milica , Yeapuri Pravin , Namminga Krista L. , Lu Yaman , Saleh Maamoon , Olson Katherine E. , Gendelman Howard E. , Mosley R. Lee 
Published: June 2022

Abstract

Background
Pharmacological approaches that boost neuroprotective regulatory T cell (Treg) number and function lead to neuroprotective activities in neurodegenerative disorders.

Objectives
We investigated whether low-dose interleukin 2 (IL-2) expands Treg populations and protects nigrostriatal dopaminergic neurons in a model of Parkinson’s disease (PD).

Methods
IL-2 at 2.5 × 104 IU/dose/mouse was administered for 5 days. Lymphocytes were isolated and phenotype determined by flow cytometric analyses. To 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) intoxicated mice, 0.5 × 106 of enriched IL-2-induced Tregs were adoptively transferred to assess the effects on nigrostriatal neuron survival.

Results
IL-2 increased frequencies of CD4+CD25+CD127lowFoxP3+ Tregs that express ICOS and CD39 in blood and spleen. Adoptive transfer of IL-2-induced Tregs to MPTP-treated recipients increased tyrosine hydroxylase (TH)+ nigral dopaminergic neuronal bodies by 51% and TH+ striatal termini by 52% compared to control MPTP-treated animal controls.

Conclusions
IL-2 expands numbers of neuroprotective Tregs providing a vehicle for neuroprotection of nigrostriatal dopaminergic neurons in a pre-clinical PD model.
Biological applications of ternary quantum dots: A review
Authors: Aladesuyi Olanrewaju A. , Lebepe Thabang C. , Maluleke Rodney , Oluwafemi Oluwatobi S. 
Published: June 2022

Abstract
Semiconductor nanomaterials, also known as quantum dots (QDs), have gained significant interest due to their outstanding optical properties with potential biological and biomedical applications. However, the presence of heavy toxic metals such as Cd, Pb, and Hg in conventional QDs have been a major challenge in their applications. Therefore, it is imperative to seek a viable alternative that will be non-toxic and have similar optical properties as the conventional QDs. Ternary I–III–VI QDs have been found to be suitable alternatives. Their optical properties are tunable and have emissions in the near-infrared region. These properties make them useful in a wide range of biological applications. Hence, this review focuses on the recent progress in the use of ternary QDs in Forster resonance energy transfer (FRET), nanomedical applications such as drug and gene delivery. It also discusses the biophotonic application of ternary I–III–VI QDs in optical imaging, biosensing, and multimodal imaging. Furthermore, we looked at the pharmacokinetics and biodistribution of these QDs, and their toxicity concerns. Finally, we looked at the current status, challenges, and future directions in the application of these ternary QDs.
Multicenter dose-escalation Phase I trial of mitomycin C pressurized intraperitoneal aerosolized chemotherapy in combination with systemic chemotherapy for appendiceal and colorectal peritoneal metastases: rationale and design
Authors: Raoof Mustafa , Sullivan Kevin M. , Frankel Paul H. , Fakih Marwan , Synold Timothy W. , Lim Dean , Woo Yanghee , Paz Isaac Benjamin , Fong Yuman , Thomas Rebecca Meera , Chang Sue , Eng Melissa , Tinsley Raechelle , Whelan Richard L. , Deperalta Danielle , Reymond Marc A. , Jones Jeremy , Merchea Amit , Dellinger Thanh H. 
Published: June 2022

AbstractObjectivesPeritoneal metastasis (PM) from appendiceal cancer or colorectal cancer (CRC) has significant morbidity and limited survival. Pressurized intraperitoneal aerosolized chemotherapy (PIPAC) is a minimally invasive approach to treat PM. We aim to conduct a dose-escalation trial of mitomycin C (MMC)-PIPAC combined with systemic chemotherapy (FOLFIRI) in patients with PM from appendiceal cancer or CRC.MethodsThis is a multicenter Phase I study of MMC-PIPAC (NCT04329494). Inclusion criteria include treatment with at least 4 months of first- or second-line systemic chemotherapy with ineligibility for cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS-HIPEC). Exclusion criteria are: progression on chemotherapy; extraperitoneal metastases; systemic chemotherapy intolerance; bowel obstruction; or poor performance status (ECOG>2). Escalating MMC-PIPAC doses (7–25 mg/m2) will be administered in combination with standard dose systemic FOLFIRI. Safety evaluation will be performed on 15 patients (dose escalation) and six expansion patients: 21 evaluable patients total.ResultsThe primary endpoints are recommended MMC dose and safety of MMC-PIPAC with FOLFIRI. Secondary endpoints are assessment of response (by peritoneal regression grade score; Response Evaluation Criteria in Solid Tumors [RECIST 1.1], and peritoneal carcinomatosis index), progression free survival, overall survival, technical failure rate, surgical complications, conversion to curative-intent CRS-HIPEC, patient-reported outcomes, and functional status. Longitudinal blood and tissue specimens will be collected for translational correlatives including pharmacokinetics, circulating biomarkers, immune profiling, and single-cell transcriptomics.ConclusionsThis Phase I trial will establish the recommended dose of MMC-PIPAC in combination with FOLFIRI. Additionally, we expect to detect an early efficacy signal for further development of this therapeutic combination.
Podcast Sebagai Media Alternatif Praktik Jurnalistik Radio oleh Tempo
Authors: Muslimah Fauziah 
Published: June 2022

The presence of podcasts is a form of development of radio journalism practice in the era of convergence. This article discusses three podcast programs on Tempo media: Berita Utama Koran Tempo, Apa Kabar Tempo, and Celetuk Bahasa Tempo. This article uses a qualitative approach to examine how the play on-demand aspect as one of a podcast's characteristics works in radio journalism practices. The results show that three Tempo podcast content applies content production practices that cannot be separated from the character of radio media, such as auditive, emphasizing conversation, at a glance, and global. The article also shows that although podcasts come with the concept of play on-demand that allows listeners to re-listen to old episodes, podcasts have not succeeded in building interaction between the mass media and their listeners. Thus, interactivity as one of the characteristics of radio journalism has not been fully present in this podcast.
Efeitos de um programa de intervenção musical na linguagem de crianças bem pequenas
Authors: Covre Josiane Fernanda , Aiello Ana Lúcia Rossito , Gil Maria Stella de Alcantara 
Published: June 2022

No desenvolvimento infantil a linguagem tem um papel fundamental por impactar nos processos cognitivos, na socialização e outros fatores que compõem o desenvolvimento das crianças até os cinco anos de idade. A literatura apresenta estudos que demonstram que a exposição à música, seja pela educação musical, seja pela musicoterapia pode oferecer suporte ao desenvolvimento de diferentes capacidades relacionadas ao uso da linguagem. O objetivo deste estudo foi verificar se um programa de intervenção musical altera o desempenho em linguagem de crianças bem pequenas. Participaram do estudo 13 crianças de 26 meses de idade (média) frequentadoras de uma creche de uma cidade do interior de São Paulo. Utilizou-se um delineamento de avaliação contínua. As crianças foram avaliadas pelo Denver II e Inventário Portage Operacionalizado (IPO) (áreas de linguagem e cognição). Elas foram expostas a 12 sessões de intervenção musical com duração de 30 minutos cada, sendo reavaliadas pelo IPO após a intervenção. Houve incremento no desempenho das crianças na área de cognição de 38% e na área de linguagem de 22%. O programa de intervenção musical realizado contribuiu para estimular o desenvolvimento da linguagem dos participantes, sendo possível afirmar que crianças a partir de 24 meses podem beneficiar-se com a participação regular em atividades musicais dirigidas no que se refere ao desempenho em linguagem
Evidenciômetro: uma ferramenta de avaliação da qualidade científica de alegações em saúde - parte I
Authors: Freitas Hercules , Gomes Pietra Almeida Rebello de Lima , Toledo Letícia Lopes Domingos 
Published: June 2022

A avaliação da validade científica de alegações em saúde é complexa e, frequentemente, subjetiva. Com o propósito de assegurar maior objetividade e reprodutibilidade ao processso, além fornecer uma ferramenta simples para profissionais e a população, propôs-se a criação de um “Evidenciômetro”. O instrumento do evidenciômetro será desenvolvido em duas etapas, sendo a primeira correspondente a este trabalho. Primeiro, um modelo de detecção do nível de evidência foi gerado, além de um aplicativo web de fácil utilização. Depois, alegações em saúde foram coletadas para análise sistemática da literatura e, finalmente, validação contra o modelo. O evidenciômetro, gerado aqui, permite a avaliação de evidências científicas através de critérios objetivos (i.e., número de evidências, tamanho amostral e de efeito), além de garantir ao público a capacidade de conhecer a validade de alegações comuns em saúde.