bluuebunny/crossref_metadata_2025_split huggingface dataset:
A NASA–Air Force Precipitation Analysis for Near-Real-Time Operations
Authors: Kemp Eric M. , Wegiel Jerry W. , Kumar Sujay V. , Geiger James V. , Mocko David M. , Jacob Jossy P. , Peters-Lidard Christa D. 
Published: June 2022

Abstract
This article describes a new precipitation analysis algorithm developed by NASA for time-sensitive operations at the United States Air Force. Implemented as part of the Land Information System—a land modeling and data assimilation software framework—this NASA–Air Force Precipitation Analysis (NAFPA) combines numerical weather prediction model outputs with rain gauge measurements and satellite estimates to produce global, gridded 3-h accumulated precipitation fields at approximately 10-km resolution. Input observations are subjected to quality control checks before being used by the Bratseth analysis algorithm that converges to optimal interpolation. NAFPA assimilates up to 3.5 million observations without artificial data thinning or selection. To evaluate this new approach, a multiyear reanalysis is generated and intercompared with eight alternative precipitation products across the contiguous United States, Africa, and the monsoon region of eastern Asia. NAFPA yields superior accuracy and correlation over low-latency (up to 14 h) alternatives (numerical weather prediction and satellite retrievals), and often outperforms high-latency (up to 3.5 months) products, although the details for the latter vary by region and product. The development of NAFPA offers a high-quality, near-real-time product for use in meteorological, land surface, and hydrological research and applications.

Significance Statement
Precipitation is a key input to land modeling systems due to effects on soil moisture and other parts of the hydrologic cycle. It is also of interest to government decision-makers due to impacts on human activities. Here we present a new precipitation analysis based on available near-real-time data. By running the program for prior years and comparing with alternative products, we demonstrate that our analysis provides better accuracy and usually less bias than near-real-time satellite data alone, and better accuracy and correlation than data provided by numerical weather models. Our analysis is also competitive with other products created months after the fact, justifying confidence in using our analysis in near-real-time operations.
How the Environmental Lifting Condensation Level Affects the Sensitivity of Simulated Convective Storm Cold Pools to the Microphysics Parameterization
Authors: Murdzek Shawn S. , Richardson Yvette P. , Markowski Paul M. , Kumjian Matthew R. 
Published: June 2022

Abstract
Several studies have documented the sensitivity of convective storm simulations to the microphysics parameterization, but there is less research documenting how these sensitivities change with environmental conditions. In this study, the influence of the lifting condensation level (LCL) on the sensitivity of simulated ordinary convective storm cold pools to the microphysics parameterization is examined. To do this, seven perturbed-microphysics ensembles with nine members each are used, where each ensemble uses a different base state with a surface-based LCL between 500 and 2000 m. A comparison of ensemble standard deviations of cold-pool properties shows a clear trend of increasing sensitivity to the microphysics as the LCL is raised. In physical terms, this trend is the result of lower relative humidities in high-LCL environments that increase low-level rain evaporational cooling rates, which magnifies differences in evaporation already present among the members of a given ensemble owing to the microphysics variations. Omitting supersaturation from the calculation of rain evaporation so that only the raindrop size distribution influences evaporation leads to more evaporation in the low-LCL simulations (owing to more drops), as well as a slightly larger spread in evaporational cooling amounts between members in the low-LCL ensembles. Cold pools in the low-LCL environments are also found to develop earlier and are initially more sensitive to raindrop breakup owing to a larger warm-cloud depth. Altogether, these results suggest that convective storms may be more predictable in low-LCL environments, and forecasts of convection in high-LCL environments may benefit the most from microphysics perturbations within an ensemble forecasting system.

Significance Statement
Computer simulations of thunderstorms can have grid spacings ranging from tens to thousands of meters. Because individual precipitation particles form on scales smaller than these grid spacings, the bulk effects of precipitation processes in models must be approximated. Past studies have found that models are sensitive to these approximations. In this study, we test whether the sensitivity to these approximations changes with the relative humidity in the lowest 1–2 km of the atmosphere. We found that increasing the relative humidity decreases the sensitivity of simulations to the precipitation process approximations. These results can inform meteorologists about the uncertainties surrounding computer-generated thunderstorm forecasts and suggest environmental conditions where using several computer models with different precipitation process approximations may be beneficial.
Canadian Network for Mood and Anxiety Treatments (CANMAT) Task Force Report: A Systematic Review and Recommendations of Cannabis use in Bipolar Disorder and Major Depressive Disorder
Authors: Tourjman Smadar V. , Buck Gabriella , Jutras-Aswad Didier , Khullar Atul , McInerney Shane , Saraf Gayatri , Pinto Jairo V. , Potvin Stephane , Poulin Marie-Josée , Frey Benicio N. , Kennedy Sidney H. , Lam Raymond W. , MacQueen Glenda , Milev Roumen , Parikh Sagar V. , Ravindran Arun , McIntyre Roger S. , Schaffer Ayal , Taylor Valerie H. , van Ameringen Michael , Yatham Lakshmi N. , Beaulieu Serge 
Published: June 2022

Background Given the increasing acceptability and legalization of cannabis in some jurisdictions, clinicians need to improve their understanding of the effect of cannabis use on mood disorders. Objective The purpose of this task force report is to examine the association between cannabis use and incidence, presentation, course and treatment of bipolar disorder and major depressive disorder, and the treatment of comorbid cannabis use disorder. Methods We conducted a systematic literature review using Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, searching PubMed, Embase, PsycINFO, CINAHL and Cochrane Central Register of Controlled Trials from inception to October 2020 focusing on cannabis use and bipolar disorder or major depressive disorder, and treatment of comorbid cannabis use disorder. The Grading of Recommendations, Assessment, Development and Evaluations (GRADE) approach was used to evaluate the quality of evidence and clinical considerations were integrated to generate Canadian Network for Mood and Anxiety Treatments recommendations. Results Of 12,691 publications, 56 met the criteria: 23 on bipolar disorder, 21 on major depressive disorder, 11 on both diagnoses and 1 on treatment of comorbid cannabis use disorder and major depressive disorder. Of 2,479,640 participants, 12,502 were comparison participants, 73,891 had bipolar disorder and 408,223 major depressive disorder without cannabis use. Of those with cannabis use, 2,761 had bipolar disorder and 5,044 major depressive disorder. The lifetime prevalence of cannabis use was 52%–71% and 6%–50% in bipolar disorder and major depressive disorder, respectively. Cannabis use was associated with worsening course and symptoms of both mood disorders, with more consistent associations in bipolar disorder than major depressive disorder: increased severity of depressive, manic and psychotic symptoms in bipolar disorder and depressive symptoms in major depressive disorder. Cannabis use was associated with increased suicidality and decreased functioning in both bipolar disorder and major depressive disorder. Treatment of comorbid cannabis use disorder and major depressive disorder did not show significant results. Conclusion The data indicate that cannabis use is associated with worsened course and functioning of bipolar disorder and major depressive disorder. Future studies should include more accurate determinations of type, amount and frequency of cannabis use and select comparison groups which allow to control for underlying common factors.
Strategies to Ensure Continuity of Care Using Telemedicine with Older Adults during COVID-19: A Qualitative Study of Physicians in Primary Care and Geriatrics
Authors: Chen Kevin , Davoodi Natalie M. , Strauss Daniel H. , Li Melinda , Jiménez Frances N. , Guthrie Kate M. , Goldberg Elizabeth M. 
Published: June 2022

Objectives: Our objective was to interview primary care physicians (PCPs) and geriatricians on their experiences using telemedicine during the COVID-19 pandemic to examine strategies used to maintain continuity of care with their patients, ages 65 and older. Methods: Using purposive sampling, we selected physicians based on community size (metro/suburban/rural) and practice setting (academic/community) and conducted semi-structured interviews via Zoom (mean: 30 minutes). Interviews were recorded, transcribed, coded, and analyzed using framework analysis. Results: We enrolled 33 physicians (15 PCPs and 18 geriatricians) from July to November 2020. Findings indicate that many physicians successfully bridged the digital divide by: assessing patients’ technological readiness in advance, being flexible with telehealth modes, using available home or facility-based staff, educating patients on telehealth privacy and usefulness, making accommodations for disabilities, and involving caregivers. Discussion: These findings can inform future policy and practice and assist physicians in resolving addressable barriers to telehealth use among older patients.
Distribution and Antimicrobial Resistance Profiles of Bacterial Aetiologies of Childhood Otitis Media in Accra, Ghana
Authors: Dayie Nicholas TKD , Bannah Vida , Dwomoh Felicia P , Kotey Fleischer CN , Donkor Eric S 
Published: June 2022

Background: Otitis media (OM), also known as middle ear infection, is a clinically significant childhood disease. In sub-Saharan Africa, there is a paucity of contemporary reports on its bacterial aetiologies and antimicrobial resistance. Aim: To investigate the OM bacterial aetiologies and their antimicrobial resistance patterns among children visiting the Ear, Nose, and Throat clinics of 3 healthcare facilities in Accra, Ghana – Princess Marie Louise Children’s Hospital, 37 Military Hospital, and Mamprobi Hospital. Methods: This cross-sectional study involved 100 children below 13 years old with suppurative otitis media. Following standard bacteriological methods, sterile ear swabs were used to take middle ear discharges from the study participants for culture and antimicrobial susceptibility testing. A standard questionnaire was also used to collect data on socio-demographic and clinical characteristics. Results: The major OM bacterial aetiologies were Pseudomonas aeruginosa (38.5%), Klebsiella pneumoniae (19.8%), Proteus mirabilis (11.5%), and Staphylococcus aureus (10.4%). The majority of the bacteria demonstrated low to moderate resistance (0%-33.3%) to most of the antibiotics. Eight of the bacteria (4 each of Klebsiella pneumoniae and Escherichia coli) were extended-spectrum beta-lactamase (ESBL) producers; 6 ampicillinase (Amp C)-producing organisms (4 Citrobacter spp. and one each of Morganella morganii and Serratia marcescens) were also identified, and they showed high antibiotic resistance. Conclusions: The predominant OM aetiologies were Pseudomonas aeruginosa, Klebsiella pneumoniae, Proteus mirabilis, and Staphylococcus aureus, and they were generally susceptible to most of the antibiotics tested. Amikacin, cefepime, ciprofloxacin, and meropenem could be valuable in the empirical management of childhood OM.
Armadillo regulates nociceptive sensitivity in the absence of injury
Authors: Hale Christine , Moulton Julie , Otis Yvonne , Ganter Geoffrey 
Published: June 2022

Abnormal pain has recently been estimated to affect ∼50 million adults each year within the United States. With many treatment options for abnormal pain, such as opioid analgesics, carrying numerous deleterious side effects, research into safer and more effective treatment options is crucial. To help elucidate the mechanisms controlling nociceptive sensitivity, the Drosophila melanogaster larval nociception model has been used to characterize well-conserved pathways through the use of genetic modification and/or injury to alter the sensitivity of experimental animals. Mammalian models have provided evidence of β-catenin signaling involvement in neuropathic pain development. By capitalizing on the conserved nature of β-catenin functions in the fruit fly, here we describe a role for Armadillo, the fly homolog to mammalian β-catenin, in regulating baseline sensitivity in the primary nociceptor of the fly, in the absence of injury, using under- and over-expression of Armadillo in a cell-specific manner. Underexpression of Armadillo resulted in hyposensitivity, while overexpression of wild-type Armadillo or expression of a degradation-resistant Armadillo resulted in hypersensitivity. Neither underexpression nor overexpression of Armadillo resulted in observed dendritic morphological changes that could contribute to behavioral phenotypes observed. These results showed that focused manipulation of Armadillo expression within the nociceptors is sufficient to modulate baseline response in the nociceptors to a noxious stimulus and that these changes are not shown to be associated with a morphogenetic effect.
Network meta-analysis of immune-oncology monotherapy as first-line treatment for advanced non-small-cell lung cancer in patients with PD-L1 expression ⩾50%
Authors: Freemantle Nick , Xu Yingxin , Wilson Florence R. , Guyot Patricia , Chen Chieh-I , Keeping Sam , Konidaris Gerasimos , Chan Keith , Kuznik Andreas , Atsou Kokuvi , Glowienka Emily , Pouliot Jean-Francois , Gullo Giuseppe , Rietschel Petra 
Published: June 2022

Background: For patients with advanced non-small-cell lung cancer (NSCLC) and high (⩾50%) programmed cell death-ligand 1 (PD-L1) expression, effective first-line immune-oncology monotherapies with significant survival benefits are approved, cemiplimab being the most recent. In a phase III trial, cemiplimab demonstrated significantly improved overall survival (OS) and progression-free survival (PFS) versus chemotherapy in patients with advanced NSCLC and PD-L1 ⩾50%. A systematic literature review and network meta-analysis (NMA) was conducted to identify/compare the efficacy/safety of cemiplimab versus pembrolizumab or other immune-oncology monotherapies from randomized-controlled trials (RCTs) published from January 2010 to November 2020. Methods: Relevant RCTs were identified by searching databases and conference proceedings as per ISPOR, NICE, and Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. NMA with time-varying hazard ratios (HRs) was performed for OS and PFS. Analyses were conducted for objective response rate (ORR) and safety/tolerability. Fixed-effect models were used due to limited evidence. Various sensitivity analyses were conducted to validate the base case analyses. Results: The feasibility assessment determined that EMPOWER-Lung 1, KEYNOTE-024, and KEYNOTE-042 trials were eligible. IMpower110 was excluded because an incompatible PD-L1 assay (SP142) was used for patient selection. For first-line advanced NSCLC with PD-L1 ⩾50%, cemiplimab was associated with statistically significant improvements in PFS [HR (95% credible interval [CrI]): 0.65 (0.50–0.86), 1–12 months] and ORR [odds ratio (OR) (95% CrI): 1.64 (1.04–2.62)], and comparable OS [HR (95% CrI): 0.77 (0.54–1.10), 1–12 months] versus pembrolizumab. There was no evidence of differences between cemiplimab and pembrolizumab for Grade 3–5 adverse events (AEs) [OR (95% CrI): 1.47 (0.83–2.60)], immune-mediated AEs [1.75 (0.33–7.49)], and all-cause discontinuation due to AEs [1.21 (0.58–2.61)]. Conclusions: Considering the limitations of indirect treatment comparisons, in patients with advanced NSCLC and PD-L1 ⩾50%, cemiplimab monotherapy demonstrated significant improvements in PFS and ORR, comparable OS, and no evidence of differences in safety/tolerability versus pembrolizumab.
Sternocleidomastoid Tendon as a Consistent Landmark for Identifying the Spinal Accessory Nerve: A Case Series
Authors: McCann Adam , Boeckermann Lauren , Jawad Basit A. , Moreno Kattia , Patil Yash 
Published: June 2022

ObjectiveWe propose a standardized approach of using the tendon of the sternocleidomastoid (SCM) muscle to locate the spinal accessory nerve (SAN) in neck dissection.Study DesignCross‐sectional anatomic study.SettingTertiary academic medical center.MethodsAdult patients aged ≥18 years undergoing primary neck dissection for head and neck cancer were included. Anatomic measurements included the length of the SCM tendon, the distance from the mastoid tip to the entrance of the SAN into the SCM, the distance from the SAN to the distal edge of the SCM tendon, and the perpendicular distance from the anterior edge of the SCM to the SAN. Five cadaveric specimens also underwent bilateral modified radical neck dissections with the same anatomic measurements taken.ResultsTwenty‐two living subjects and 5 cadavers were included. No statistical correlation was noted between patient demographics and any measurement. The mean (SD) length of the SCM tendon was 63.7 mm (11.8) in living subjects and 61.5 mm (10.4) in cadaveric specimens. The average distance from the mastoid tip to the entrance of SAN into the SCM was 51.6 mm (12.2) in living subjects and 51.6 mm (7.1) in cadaveric subjects. The distance of the SAN insertion into the SCM muscle from the anterior edge was 8.9 mm (3.4) in living subjects and 16.2 mm (7.2) in cadaver specimens. Laterality was compared in the cadaveric specimens; there was no statistically significant difference in any of the measurements between sides.ConclusionThis study demonstrates the SCM tendon to be a reliable and safe surgical landmark to identify and preserve the SAN during neck dissection.
Public Perception of SARS-CoV-2 Vaccines Among Psoriasis Patients in Social Media: Content, Sentiment, and Engagement Analysis
Authors: Yee Danielle , Khan Sabrina , Zagona-Prizio Caterina , Maynard Nicole , Reddy Rasika , Khan Samiya , Mehta Manan , Armstrong April W. 
Published: June 2022

Background Psoriasis patients may seek information about the SARS-CoV-2 vaccine and their disease from social media platforms. Analyses of social media interactions may help guide dermatologists’ educational efforts during this pandemic. Objectives This study analyzes social media interactions among patients with psoriasis and psoriatic arthritis regarding the SARS-CoV-2 vaccine to determine the misinformation circulating and the apprehension to receiving the vaccine. Methods Publicly accessible Facebook and Reddit groups regarding psoriasis and psoriatic arthritis were identified. Posts uploaded between March 1, 2021 and July 31, 2021 which contained information about the SARS-CoV-2 vaccine were extracted. First-order themes, sub-themes, sentiment scores and engagement scores were assigned to each post. Results 345 posts within the first-order theme of vaccination decision and 1379 posts within the first-order theme of vaccine reaction were analyzed. Within vaccination decision, common sub-themes for refusing the vaccine include fear of psoriasis flare up, vaccine is experimental, vaccine is unnecessary, vaccine is dangerous, and concern for reaction/vaccine efficacy while on psoriasis medications. 41.4% of posts contained positive sentiment; whereas, 38.3% contained negative sentiment. Within vaccine reaction, common sub-themes identified were no change to psoriasis, skin/joint flare up, skin flare up attributed specifically to stopping psoriasis medications, skin/joint improvement, and skin flare up but vaccine was worth it. 77.8% of posts contained positive sentiment; whereas, 6.2% contained negative sentiment. Conclusions Our study identified common SARS-CoV-2 vaccine concerns within the psoriasis community which should be used to guide educational efforts.
Nafeasite, NaFe3+(AsO3OH)2⋅H2O, a new framework arsenate from the Torrecillas mine, Iquique Province, Chile
Authors: Kampf Anthony R. , Schlüter Jochen , Malcherek Thomas , Paulenz Bianca , Pohl Dieter , Ma Chi , Dini Maurizio , Molina Donoso Arturo A. 
Published: June 2022

AbstractThe new mineral nafeasite (IMA2021-103), NaFe3+(AsO3OH)2⋅H2O, was found at the Torrecillas mine, Iquique Province, Chile, where it is a secondary alteration phase associated with anhydrite, gypsum, halite, lavendulan, magnesiokoritnigite and natrojarosite. Nafeasite occurs in tightly intergrown aggregates of equant crystals. Crystals are light to medium pink and transparent, with vitreous lustre and white streak. The Mohs hardness is ~2½. The density is 3.23(2) g⋅cm–3. Optically, nafeasite is biaxial (+), with α = 1.679(3), β = 1.682(3), γ = 1.730(5) (white light); 2V = 27(2)°; and slight r < v dispersion. The empirical formulae of the holotype and cotype (based on 9 O atoms per formula unit) are Na0.98K0.02Fe0.92Al0.07As2.00O9H4.01 and Na0.97Fe0.68Al0.33As2.00O9H4.01, respectively. Nafeasite is monoclinic, space group C2, with cell parameters: a = 18.6876(16), b = 8.6769(7), c = 14.8100(10) Å, β = 105.238 (5)°, V = 2317.0(3) Å3 and Z = 12. The structure, refined to R1 = 5.03% for 5979 Io > 2σI reflections, is based on a loose 3D framework of alternating AsO3OH tetrahedra and Fe3+O6 octahedra.
The oral ferroportin inhibitor vamifeport improves hemodynamics in a mouse model of sickle cell disease
Authors: Nyffenegger Naja , Zennadi Rahima , Kalleda Natarajaswamy , Flace Anna , Ingoglia Giada , Buzzi Raphael M. , Doucerain Cédric , Buehler Paul W. , Schaer Dominik J. , Dürrenberger Franz , Manolova Vania 
Published: June 2022

Abstract
Sickle cell disease (SCD) is an inherited hemolytic anemia caused by a single point mutation in the β-globin gene of hemoglobin that leads to synthesis of sickle hemoglobin (HbS) in red blood cells (RBCs). HbS polymerizes in hypoxic conditions, leading to intravascular hemolysis, release of free hemoglobin and heme, and increased adhesion of blood cells to the endothelial vasculature, which causes painful vaso-occlusion and organ damage. HbS polymerization kinetics are strongly dependent on the intracellular HbS concentration; a relatively small reduction in cellular HbS concentration may prevent HbS polymerization and its sequelae. We hypothesized that iron restriction via blocking ferroportin, the unique iron transporter in mammals, might reduce HbS concentration in RBCs, thereby decreasing hemolysis, improving blood flow, and preventing vaso-occlusive events. Indeed, vamifeport (also known as VIT-2763), a clinical-stage oral ferroportin inhibitor, reduced hemolysis markers in the Townes model of SCD. The RBC indices of vamifeport-treated male and female Townes mice exhibited changes attributable to iron-restricted erythropoiesis: decreased corpuscular hemoglobin concentration mean and mean corpuscular volume, as well as increased hypochromic and microcytic RBC fractions. Furthermore, vamifeport reduced plasma soluble VCAM-1 concentrations, which suggests lowered vascular inflammation. Accordingly, intravital video microscopy of fluorescently labeled blood cells in the microvasculature of Townes mice treated with vamifeport revealed diminished adhesion to the endothelium and improved hemodynamics. These preclinical data provide a strong proof-of-concept for vamifeport in the Townes model of SCD and support further development of this compound as a potential novel therapy in SCD.