bluuebunny/crossref_metadata_2025_split huggingface dataset:
Low frequency pulsed electromagnetic fields exposure alleviate the abnormal subchondral bone remodeling at the early stage of temporomandibular joint osteoarthritis
Authors: Ma Yuanjun , Chen Xiaohua , He Feng , Li Shi , He Rui , Liu Qian , Dong Qingshan , Zhou Shuncheng , Miao Hui , Lu Qian , Li Feifei , Yang Hongxu , Zhang Mian , Lin Yuan , Yu Shibin 
Published: September 2022

AbstractBackground Temporomandibular joint osteoarthritis (TMJOA) is characterized by abnormal subchondral bone remodeling and cartilage degeneration. As a non-invasive biophysical technology, pulsed electromagnetic field (PEMF) treatment has been proven to be efficient in promoting osteogenesis. However, the potential bone protective effect and mechanism of PEMF on abnormal subchondral bone remodeling in TMJOA are unknown. Methods Unilateral anterior crossbite (UAC) was used to create TMJOA model in rats, and 17β-estradiol (E2) were injected daily to mimic patients with high-physiological levels of estrogen. Mouse osteoblast-like MC3T3-E1 cells treated with recombinant murine IL-1β was used to establish inflammatory environmentin vitro. The treatment group were subjected to PEMF (2.0mT, 15 Hz, 2h/d). Micro-CT scanning, histological staining, real-time PCR and western blotting assays were preformed to observe the changes in the subchondral bone. Results Abnormal resorption of subchondral bone induced by UAC, characterized by decreased bone mineral density, increased osteoclast activity and expression of osteoclast-related factors (RANKL) and down-regulated expression of osteogenesis-related factors (OPG, ALP, Runx2 and OCN) at the early stage, could be reversed by PEMF exposure, which was similar to the effect of estrogen. In addition, PEMF exposure and E2supplement may have a synergistic effect to some extent. Moreover, PEMF exposure could promote the ALP activity and osteogenic mineralization ability of MC3T3-E1 cells. PEMF promoted the expression of factors related to Wnt/β-Catenin signal pathway bothin vivoandin vitro. Conclusions Appropriate PEMF exposure have a protective effect on subchondral bone in TMJOA at early stage, in which canonical Wnt/β-Catenin pathway may be involved. PEMF may be a promising biophysical approach for early intervention of TMJOA in clinic.
Automatic quantitative measurement of left atrial pressure using mitral regurgitation spectrum：Clinical study on comparison with floating cathete
Authors: Jin Yan , Wen Chao-yang , Yue Fengjie , Wang Huishan , Yin Liancheng , Mao Keming , Xin Fangran 
Published: September 2022

Abstract
To explore how to measure LAPEp accurately and quantitatively, that is, the left atrial pressure (LAP) measured and calculated by equation method using mitral regurgitation spectrum. Methods The mitral regurgitation spectrum, pulmonary arteriolar wedge pressure (PAWP) and invasive arterial systolic pressure of radial artery of 28 patients were collected simultaneously, including 3 patients with rheumatic heart disease, 15 patients with mitral valve prolapse and 10 patients with coronary artery bypass grafting, patients with moderate or above aortic stenosis were excluded. LAPBp(Doppler sphygmomanometer method), LAPEq (Equation method) and LAPC (Catheter method) were measured synchronously, and the measurement results of the three methods were compared and analyzed. We designed a special intelligent Doppler spectrum analysis software to accurately measure LAPEq. Results Found that there was no significant statistical difference between the measurement results of LAPC and LAPEq (t = 0.954, P = 0.348),and significant correlation between the two methods [r = 0.908(0.844,0.964), P < 0.001]. Although the measurement results of LAPC and LAPBP are consistent in some patients, there are significant differences in the overall case and weak correlation between the two methods [r = 0.210, (−0.101, 0.510), P = 0.090]. In MVP patients with P1 or P3 prolapse, the peak pressure difference of MR was underestimated due to the serious eccentricity of MR, which affected the accuracy of LAPBP measurement. This study had been approved by the ethics committee of the northern theater general hospital ( K-2019-17), applied prospectively for clinical trial (No. Chictr 190023812) and invention patent application (No. 202210711862.X). Conclusions This study shows that there is a good correlation between LAPEq and LAPC, which verifies that the noninvasive and direct quantitative measurement of left atrial pressure based on mitral regurgitation spectrum is feasible and has a good application prospect.
Estimator-Based Adaptive Consensus Asymptotic Tracking Control for Constrained Nonlinear MASs Under DoS Attacks and Actuator Faults
Authors: Jiang Yuqiang , Niu Ben , Wang Li , Wang Xinjun , Wang Xiaomei 
Published: September 2022

Abstract
When the denial-of-service (DoS) attacks and the actuator faults exist simultaneously, this paper considers the problem of estimator-based adaptive consensus asymptotic tracking control for a class of constrained nonlinear multi-agent systems (MASs) with the state constraints. In light of the fact that the consensus tracking performance of the researched nonlinear MASs will be seriously impaired by the DoS attacks and actuator faults, a novel secure consensus asymptotic tracking control algorithm is developed. Due to only the output information of each agent can be obtained, the design difficulty of the security control algorithm is greatly increased. Following that, an estimator that approximates the unknown nonlinearities and observes the immeasurable system states is constructed for each agent. Furthermore, the barrier Lyapunov functions (BLFs) are introduced to solve the state constraint requirements of each agent, meanwhile the dynamic surface control (DSC) technology is used to overcome the difficulty of ``explosion of complexity'' in the backstepping process. The proposed event-triggered anti-attack controller guarantees that all closed-loop signals remain bounded, and the consensus tracking errors asymptotically converge to zero. At last, the proposed control algorithm is applied to a forced damped pendulums (FDPs) to verify the correctness of the theoretical result.
Contraceptive use: Does data from the 2018 Nigeria Demographic and Health Survey indicate a shift from awareness to actual practice among sexually active childbearing women in South-south Nigeria?
Authors: Ukoji Vitalis U. , Anele Princewill O. , Imo Chukwuechefulam K. 
Published: September 2022

Abstract
Background
Nigeria has one of the highest fertility rates in the world, which is problematic for public health and a major obstacle to socioeconomic growth. Nigeria’s high fertility rate is caused in part because of low contraceptive use among sexually active childbearing women. However, the Nigerian government and other development partners are working to reduce fertility by increasing the use of contraceptives. Consequently, this research looked at sexually active childbearing women’s knowledge of and actual use of contraception in South-south Nigeria.
Methods
The study utilised cross-sectional data from the 2018 Nigeria Demographic and Health Survey. Being the sixth in the series conducted in the country, the 2018 National Demographic and Health Survey is a nationally representative survey of women of childbearing ages 15–49 years and men aged 15–59 years. One of Nigeria’s six geopolitical zones, the South-south, provided data on 4553 sexually active childbearing women, which were retrieved and analysed using descriptive and Chi-square statistics at P ≤ 0.05.
Results
Eighty-two percent of respondents knew about at least one form of contraception, and 63% and 32% agreed that using contraception prevents undesired pregnancies and spacing children, respectively. Regardless of the widespread awareness of contraceptives, approximately 82% of respondents reported they never use any form of contraception. In comparison to 4.2% who reported utilising traditional methods, 14.06% reported using modern methods. Compared to Bayelsa State (3.8%), Rivers State had the highest prevalence for ever using contraceptives (39.5%). The standard-days technique was shown to be the least frequent method of contraception, with the male condom being the most common at 36.4%. Significant influences on the usage of contraceptives included age (P = 0.00), education (P = 0.00), work status (P = 0.00), wealth index (P = 0.00), religion (P = 0.00), knowledge of contraceptive options (P = 0.00), and the desire to have more children (P = 0.00).
Conclusions
Among sexually active childbearing women in Nigeria’s South-south geopolitical zone, the high awareness of contraception has not translated into actual practice. To improve on Nigeria’s low contraceptive prevalence rate and achieve the Sustainable Development Goals for maternal health, some issues that lie between contraceptive awareness and actual adoption must be unravelled and addressed head-on.
Fast Bayesian Optimization of Needle-in-a-Haystack Problems using Zooming Memory-Based Initialization
Authors: Siemenn Alexander , Ren Zekun , Li Qianxiao , Buonassisi Tonio 
Published: September 2022

Abstract
Needle-in-a-Haystack problems exist across a wide range of applications including rare disease prediction, ecological resource management, fraud detection, and material property optimization. A Needle-in-a-Haystack problem arises when there is an extreme imbalance of optimum conditions relative to the size of the dataset. For example, only 0.82% out of 146k total materials in the open-access Materials Project database have a negative Poisson's ratio. However, current state-of-the-art optimization algorithms are not designed with the capabilities to find solutions to these challenging multidimensional Needle-in-a-Haystack problems, resulting in slow convergence to a global optimum or pigeonholing into a local minimum. In this paper, we present a Zooming Memory-Based Initialization algorithm, entitled ZoMBI, that builds on conventional Bayesian optimization principles to quickly and efficiently optimize Needle-in-a-Haystack problems in both less time and fewer experiments by addressing the common convergence and pigeonholing issues. ZoMBI actively extracts knowledge from the previously best-performing evaluated experiments to iteratively zoom in the sampling search bounds towards the global optimum "needle" and then prunes the memory of low-performing historical experiments to accelerate compute times by reducing the algorithm time complexity from O(n3) to O(1), as the number of experiments sampled increases. Additionally, ZoMBI implements two custom acquisition functions that use active learning to further guide the sampling of new experiments towards the global optimum. We validate the algorithm's performance on two real-world 5-dimensional Needle-in-a-Haystack material property optimization datasets: discovery of auxetic Poisson's ratio materials and discovery of high thermoelectric figure of merit materials. The ZoMBI algorithm demonstrates compute time speed-ups of 400x compared to traditional Bayesian optimization as well as efficiently discovering materials in under 100 experiments that are up to 3x more highly optimized than those discovered by current state-of-the-art algorithms.
Seroprevalence and associated risk factors of Neospora caninum in cattle in the Khomas region of Namibia
Authors: Samkange Alaster , Chitanga Simbarashe , Tjipura-Zaire Georgina , Mutjavikua Vimanuka Gibs , Smith Jan Wilhelm , Neves Luis , Matjila Tshepo 
Published: September 2022

Abstract

Neospora caninumis a coccidian parasite which occurs worldwide and is one of the most important causes of abortion, especially in cattle. However, no studies have been done in Namibia to determine theN. caninumstatus in livestock. Therefore, this study aimed to determine the seroprevalence level ofN. caninumin cattle and the associated risk factors in the Khomas region of Namibia. Seven hundred thirty-six (736) serum samples were collected from female cattle in 32 farming establishments. These comprised 698 beef and 38 dairy cattle sera and were tested using a commercial IDEXXNeosporaX2® ELISA kit. Questionnaires were concurrently administered to determine possible risk factors associated withN. caninumseropositivity. A total of 42 sera were positive (all beef), giving an animal-level seroprevalence rate of 5.7%. Eight of the 32 establishments had at least one positive animal, giving a herd-level seroprevalence of 25%. There was no significant association between seropositivity and the presence of dogs, jackals, history of abortions, farm size, number of cattle or average annual rainfall. The establishments with moderate to high numbers of Feliformia were 9.8 times more likely to be seropositive toN. caninumthan those with none to low levels of the former (p = 0.0245). The authors concluded that the seroprevalence level ofN. caninumin the Khomas region was relatively low compared to other parts of the world and that the role of Feliformia in the epidemiology of bovine neosporosis needed to be further investigated.
Structural and Heat Treatment Analysis of 316l Elaborated by SLM Additive Manufacturing Process
Authors: Fri K. , Laazizi Abdellah , Bensada Mouad , Alami Mohammed El , Ouannou Abdelmalek , Akhrif Iatimad , Jai Mostapha El , FAJOUI Jamal 
Published: September 2022

Abstract
Metal additive manufacturing is an emerging advanced technology, it differs from conventional manufacturing methods as machining, casting and forging, which are either subtractive or forming. Firstly, the objective of this work is to elaborate a new 316L stainless steel material by Selective Laser Melting (SLM) from metallic powder according to specific operating parameters namely laser scanning speed and power. Secondly, the characterization of this developed material by 3D printing is carried out. For this purpose, metallographic observations and heat treatments at different temperatures 650, 800 and 1050°C were performed. Thus, the contribution of this study is to develop procedure and tools to enhance their mechanical properties at the level of parts obtained by conventional processes. Therefore, samples were examined by X-RF, SEM, EDS mapping, density, and hardness measurements as well. Results show that mechanical properties of additive manufactured samples can be improved in certain conditions linked to operating parameters and heat treatment. Also, this work has allowed us to confirm the resistance of the 316L stainless steel developed by SLM to high temperatures.
Depletion of BTAF1 inhibits Epithelial-to-mesenchymal Transition via the TGF-β Signal pathway in the osteosarcoma
Authors: Xia Tao , Yang Yuanqing , Ying Zhengran , Wang Zhizhou , Zhang Hailong 
Published: September 2022

Abstract
Osteosarcoma (OS) is one of the most malignant tumors of bone with a poor outcome in children and young adolescents and has a poor response to radiotherapy and chemotherapy.At present, it is urgent to find effective biomarkers to prevent and treat osteosarcoma.The BTAF1 (formerly known as TAFII170/TAF-172 and the human ortholog of Saccharomyces cerevisiae Mot1p),are evolutionarily conserved members of the SNF2-like family of ATPase proteins, and it has never been studied in OS.In this study, we first revealed BTAF1 is significantly upregulated in OS, and its expression level is highly correlated with clinicopathological parameters of OS patients. Our Survival curve analysis demonstrated that BTAF1 is a candidate predictor for predicting patient prognosis.Functional experiment results showed BTAF1 promotes the proliferation of OS cells in vitro.Silencing of BTAF1 reduces the colony-forming ability of U2OS cells in vitro and reduces tumor growth in vivo. Mechanism studies have shown that inhibition of BTAF1 reduces the epithelial-to-mesenchymal transition (EMT) through the TGF-β signaling pathway to inhibit OS progression.In summary, BTAF1 plays a regulatory role in the progression of OS,and it may be a new OS diagnostic marker and prognostic factor, providing new ideas for the treatment of OS.
Outcomes of endoscopic papillary large balloon dilatation combined with sphincterotomy for removing large common bile duct stones and risk factors for stone recurrence
Authors: Yu Sanyang , Fan Yan , Dong Shouquan , Zhao Qiu , Wang Hongling 
Published: September 2022

AbstractBackground To evaluate the outcomes of endoscopic sphincterotomy (EST) combined with endoscopic papillary large balloon dilation (EPLBD) for removing stones from large common bile duct (CBD) and identify the risk factors for stone recurrence. Methods After reviewing 69 patients with large CBD stones, 44 were included in the group treated with EST combined with EPLBD (ESLBD) and 25 patients were in included in the EPLBD group. The clinical data of both groups, including success rates of removing large CBD stones, complications, hospital stay and total costs of hospitalization were compared. In addition, the risk factors for stone recurrence were explored. Results The ESLBD and EPLBD groups showed similar success rates of stone clearance (97.27% vs 96.00%). However, the use of lithotripsy and the incidence of post-endoscopy pancreatitis (PEP) were higher in the EPLBD group. The recovery time and total costs of hospitalization were also lower in the ESLBD group. No serious complications were identified in our study, such as hemorrhage, perforation and death; and no significant differences in infection, procedural time, hospital stay and procedural costs of groups. Multiple logistic regression analysis showed that lithotripsy and maximum transverse diameter of the CBD stone were independent risk factors for stone recurrence. Conclusions ESLBD was superior to EPLBD alone for removing large CBD stones. In addition, the maximum transverse diameter of CBD stone and lithotripsy were independent risk factors for associated with stone recurrence.
Single-cell RNA-seq analysis uncovers hypoxia-induced changes in hematopoietic stem cells and fate decisions of progenitors
Authors: Wang Haijing , Cai Zhenyuan , Song Pengfei , Liu Daoxin , Jiang Feng , Xu Bo , Zhang Tongzuo 
Published: September 2022

Abstract
Hypoxia is a common phenomenon in about 5–10% of the world's population who maladapted to the high altitude environment. Hypoxia is associated with multiple pathophysiological processes, among which hematologic problems are the best-known. However, the underlying molecular mechanism remains unclear, especially in the early stage of hematopoiesis. Single-cell RNA sequencing (scRNA-seq) captures instantaneous transitions between different states of the cell population and can therefore be employed to enhance our understanding of cell fate choices in hematopoiesis. In this study, hematopoietic stem cells and their progeny were collected in homeostasis as the control group and after 13 days of exposure to hypoxia as the treatment group. scRNA-seq was employed to establish an atlas of hematopoietic stem progenitor cells and identify differences in the choice of cell fate. 4,909 and 3,482 cells were obtained in hypoxia and control groups, respectively. An atlas was established, and 14 cell types were identified. After hypoxic treatment, trajectory analysis found a bias toward erythroid and mononuclear lineages, and cell cycle genes are more likely to be involved in erythropoiesis. Cell communication in the niche was explored, and mesenchymal stem cells were found to be related to mononuclear differentiation and mobilization. In addition, stem cells were increased in the quiescent state. These findings highlight the influence of hematopoiesis in the bone marrow when the body overcomes hypoxia, and provide new clues on the molecular mechanism of maladaptation to high altitudes.
Fremanezumab Improved Migraine and Headache Attributed to Glioblastoma -Case Report-
Authors: Kawamura Shin , Katsuki Masahito , Kashiwagi Kenta , Koh Akihito 
Published: September 2022

Abstract
Fremanezumab, one of anti-calcitonin gene-related peptide monoclonal antibodies, is widely used for migraine prophylaxis. However, its efficacy for headache attributed to glioblastoma has not been reported. We herein report a 66-year-old man who had right temporoparietal glioblastoma which recurred despite surgical and chemo-radiological treatment. He had migraine and headache attributed to glioblastoma, but fremanezumab improved them. Our case suggested that fremanezumab’s possible efficacy for not only migraine but also headache attributed to intracranial neoplasia.
A NIR Fluorescent Probe Benzopyrylium Perchlorate-based for Visual Sensing and Imaging of SO 2 Derivatives in Living Cells
Authors: Luo Xiao Ye , Xie Juan , Zhao Guang Lian , Li Gui Yong , Qu Hang Da , Yang Yu Zhu 
Published: September 2022

Abstract
Endogenous sulfur dioxide (SO2), as a gas signal molecule, has a certain physiological functions. Understanding the role of endogenous SO2 in human physiology and pathology is of great significance to the biological characteristics of SO2,which bring
challenges to develop fluorescent probes with excellent performance. Herein, we rationally designed and constructed a novel near-infrared bioprobe benzaldehyde-benzopyrylium (BBp) by employing the nucleophilic addition benzopyrylium perchlorate fluorophore and benzaldehyde moiety by means of C=C/C=O group that serves as both fluorescence reporting unit. Probe BBp exhibit excellent sensing performance with fluorescent “On−Off”rapid response (100 s ) and long-wavelength emission (670 nm). With the treatment of HSO3−, the color of BBp solution obviously varies from purple to colorless, and the fluorescent color varies from red to colorless. By the fluorescence and colorimetric changes, probe BBp was capable of sensitive determination HSO3-with low limits of detection (LOD) of 0.43 μM, realizing visual quantitative monitoring SO2 derivative levels. Due to the low phototoxicity and good biocompatibility, it was successfully applied to monitor SO2 derivatives and fluorescence imaging in HepG2 and HeLa living cells. Hopefully, this work supplies a new strategy for designing NIR fluorescent probes for quantitative determination SO2 derivatives in biological samples.