bluuebunny/crossref_metadata_2025_split huggingface dataset:
Engagement and attrition with eHealth tools for remote monitoring in chronic arthritis: a systematic review and meta-analysis
Authors: Doumen Michaël , De Cock Diederik , Van Lierde Caroline , Betrains Albrecht , Pazmino Sofia , Bertrand Delphine , Westhovens René , Verschueren Patrick 
Published: October 2022

ObjectivesAlthough eHealth tools are potentially useful for remote disease monitoring, barriers include concerns of low engagement and high attrition. We aimed to summarise evidence on patients’ engagement and attrition with eHealth tools for remotely monitoring disease activity/impact in chronic arthritis.MethodsA systematic literature search was conducted for original articles and abstracts published before September 2022. Eligible studies reported quantitative measures of patients’ engagement with eHealth instruments used for remote monitoring in chronic arthritis. Engagement rates were pooled using random effects meta-analysis.ResultsOf 8246 references, 45 studies were included: 23 using smartphone applications, 13 evaluating wearable activity trackers, 7 using personal digital assistants, 6 including web-based platforms and 2 using short message service. Wearable-based studies mostly reported engagement as the proportion of days the tracker was worn (70% pooled across 6 studies). For other eHealth tools, engagement was mostly reported as completion rates for remote patient-reported outcomes (PROs). The pooled completion rate was 80%, although between-study heterogeneity was high (I293%) with significant differences between eHealth tools and frequency of PRO-collection. Engagement significantly decreased with longer study duration, but attrition varied across studies (0%–89%). Several predictors of higher engagement were reported. Data on the influence of PRO-reporting frequency were conflicting.ConclusionGenerally high patient engagement was reported with eHealth tools for remote monitoring in chronic arthritis. However, we found considerable between-study heterogeneity and a relative lack of real-world data. Future studies should use standardised measures of engagement, preferably assessed in a daily practice setting.Trial registeration numberThe protocol was registered on PROSPERO (CRD42021267936).
Five months under ice: biologging reveals behaviour patterns of overwintering freshwater turtles
Authors: Robichaud Jessica A. , Bulté Grégory , MacMillan Heath A. , Cooke Steven J. 
Published: October 2022

Winter in temperate regions is characteristically the coldest period of the year. Species in these regions adapt to freezing temperatures with physiological or behavioural mechanisms to mitigate the threats of cold exposure. For aquatic species, taking refuge under the ice minimizes the risk of experiencing freeze injury. The northern map turtle ( Graptemys geographica (LeSueur, 1817)) is one species that overwinters under the ice of lakes and rivers. Here, we observed the behaviour of free-ranging map turtles at a known overwintering site throughout an entire winter using biologgers equipped with tri-axial acceleration, temperature, and depth sensors. We observed that map turtles maintain localized locomotor activity at the overwintering site continuously during the winter. The extent and patterns of locomotor activity and habitat use varied between adult females, adult males, and juvenile females. Adult females were observed at the shallowest depths, coldest temperatures and moved the least, whereas juvenile females were observed at the deepest depths, warmest temperatures and moved the most. All groups remained at temperatures near freezing (0.98–1.39 °C) and at average depths ranging from 1.34 to 1.7 m. These behavioural patterns are consistent with a strategy to survive the winter while remaining aerobic and likely reflect differences in physiological demands.
Fixed points in supersymmetric extensions of the standard model
Authors: Hiller Gudrun , Litim Daniel F. , Moch Kevin 
Published: October 2022

AbstractWe search for weakly interacting fixed points in extensions of the minimally supersymmetric standard model (MSSM). Necessary conditions lead to three distinct classes of anomaly-free extensions involving either new quark singlets, new quark doublets, or a fourth generation. While interacting fixed points arise prolifically in asymptotically free theories, their existence is significantly constrained as soon as some of the non-abelian gauge sectors are infrared free. Performing a scan over $$\sim 200$$

∼
200

k different MSSM extensions using matter field multiplicities and the number of superpotential couplings as free parameters, we find mostly infrared conformal fixed points, and a small subset with ultraviolet ones. All settings predict low-scale supersymmetry-breaking and a violation of R-parity. Despite of residual interactions, the running of couplings out of asymptotically safe fixed points is logarithmic as in asymptotic freedom. Some fixed points can be matched to the Standard Model though the matching scale comes out too low. Prospects for higher matching scales and asymptotic safety beyond the MSSM are indicated.
Possibility of $$T_{c\bar{s}}(2900)$$ as the resonance-like structure induced by threshold effects
Authors: Ge Ying-Hui , Liu Xiao-Hai , Ke Hong-Wei 
Published: October 2022

AbstractWe investigate the process $$B\rightarrow \bar{D}D_s \pi $$

B
→

D

¯

D
s

π

via several rescattering processes. It is shown that the triangle singularity (TS) peak around the $$D^*K^*$$

D
∗

K
∗

threshold generated from the $$\chi _{c1}K^* D^*$$

χ

c
1

K
∗

D
∗

loop is relatively narrow, which may simulate the resonance-like structure $$T_{c\bar{s}}(2900)$$

T

c

s

¯

(
2900
)

recently observed by LHCb in the $$D_s\pi $$

D
s

π

spectrum. However, the TS peak around the $$D_s^*\rho $$

D
s
∗

ρ

threshold generated from the $$D^{**} D_s^* \rho $$

D

∗

∗

D
s
∗

ρ

loop is smoothed by the broad width of $$\rho $$
ρ
, which itself can hardly describe the $$T_{c\bar{s}}(2900)$$

T

c

s

¯

(
2900
)

structure. A non-resonance TS signal around the DK threshold generated from the $$\chi _{c0}K D $$

χ

c
0

K
D

loop is also predicted.
Leptonic anomalous magnetic and electric dipole moments in the CP-violating NMSSM with and without inverse seesaw mechanism
Authors: Dao Thi Nhung , Le Duc Ninh , Mühlleitner Margarete 
Published: October 2022

AbstractThe new results on the muon anomalous magnetic moment (AMM) published by Fermilab in 2021 did not lead to a reduction of its long-pending deviation from the Standard Model (SM) value by more than 4$$\sigma $$
σ
. The explanation of this discrepancy by adding new particles to the theory puts many new physics models under tension when combined with the null results of the LHC direct searches for new particles. In this paper, we investigate the CP-violating Next-to-Minimal Supersymmetric extension of the SM (NMSSM) with and without an inverse seesaw mechanism. We compute the one-loop supersymmetric contributions to the AMM and the two-loop Barr–Zee-type diagrams with effective Higgs couplings to photons for the leptonic electric dipole moments (EDMs). The effects of the extended (s)neutrino sector on the muon AMM and on the mass of the SM-like Higgs boson can be significant. Complex phases can have an important impact on the AMM. On the other hand, the stringent limits from the EDMs on the complex phases have to be taken into account. Our calculations have been implemented in the Fortran codes and which are publicly available. Besides the leptonic AMMs and EDMs, these programs can compute the Higgs boson masses and mixings, together with Higgs boson decay widths and branching ratios taking into account the most up-to-date higher-order corrections in the NMSSM with and without inverse seesaw mechanism.
Light-cone sum rule analysis of semileptonic decays $$\varLambda _b^0 \rightarrow \varLambda _c^+ \ell ^- {\overline{\nu }}_\ell $$
Authors: Duan Hui-Hui , Liu Yong-Lu , Huang Ming-Qiu 
Published: October 2022

AbstractIn this work, we analyze the semileptonic decay processes of $$\varLambda _b \rightarrow \varLambda _c$$

Λ
b

→

Λ
c

in the light-cone sum rule approach. In order to calculate the form factors of the $$\varLambda _b$$

Λ
b

baryon transition matrix element, we use the light-cone distribution amplitudes of $$\varLambda _b$$

Λ
b

obtained from the QCD sum rule in the heavy quark effective field theory framework. With the calculation of the six form factors of the $$\varLambda _b \rightarrow \varLambda _c$$

Λ
b

→

Λ
c

transition matrix element, the differential decay widths of $$\varLambda _b^0 \rightarrow \varLambda _c^+ \ell ^- {\overline{\nu }}_\ell (\ell = e, ~\mu , ~\tau )$$

Λ
b
0

→

Λ
c
+

ℓ
-

ν
¯

ℓ

(
ℓ
=
e
,

μ
,

τ
)

and their absolute branching fractions are obtained. Additionally, the ratio of $$R(\varLambda _c^+) \equiv {\mathcal {B}}r(\varLambda _b^0 \rightarrow \varLambda _c^+ \tau ^- {\overline{\nu }}_\tau )/{\mathcal {B}}r(\varLambda _b^0 \rightarrow \varLambda _c^+ \mu ^- {\overline{\nu }}_\mu )$$

R

(

Λ
c
+

)

≡
B
r

(

Λ
b
0

→

Λ
c
+

τ
-

ν
¯

τ

)

/
B
r

(

Λ
b
0

→

Λ
c
+

μ
-

ν
¯

μ

)

is also obtained in this work. Our results are in accord with the newest experimental result and other theoretical calculations and predictions.
Regularising experimental correlations in LHC data: theory and application to a global analysis of parton distributions
Authors: Kassabov Zahari , Nocera Emanuele R. , Wilson Michael 
Published: October 2022

AbstractWe show how an inaccurate determination of experimental uncertainty correlations in high-precision LHC measurements may undermine the reliability of the associated $$\chi ^2$$

χ
2

. We formulate the problem rigorously, and devise a regularisation procedure that increases the stability of the $$\chi ^2$$

χ
2

by altering the covariance matrix of the measurement as little as possible. We apply the procedure to the NNPDF4.0 global analysis of parton distribution functions that utilises a large amount of LHC measurements. We find that the regularised $$\chi ^2$$

χ
2

of the NNPDF4.0 determination is lowered by about $$3\sigma $$

3
σ

, without significantly altering the resulting PDFs upon refitting.
Unraveling the role of the thermal and laser impacts on the blackening of cinnabar in the mural paintings of Pompeii
Authors: Pérez-Diez Silvia , Larrañaga Aitor , Madariaga Juan Manuel , Maguregui Maite 
Published: October 2022

AbstractThe blackening of red cinnabar (α-HgS) pigment has traditionally been explained by its conversion into black metacinnabar (β-HgS). Scarce is however the scientific evidence that supports this hypothesis in polychrome artworks. As such transition occurs at around 345 °C, the thermal impact of the eruption of Mount Vesuvius in 79 AD could have induced this structural change of the pigment present in the mural paintings of Pompeii. This work aims to assess whether the mentioned volcanic eruption could be responsible of the cinnabar blackening through the formation of metacinnabar. The thermodiffractometry study of cinnabar-decorated fresco mock-ups stated that the formed β-HgS is not stable, observing its reversion into α-HgS. Moreover, sublimation of the cinnabar pictorial layer was registered, also when the cinnabar paint layer was protected by a coating of pyroclastic materials. In real blackened cinnabar Pompeian samples, it was not possible to identify metacinnabar by X-ray diffraction (XRD), but evidence of sublimation of mercury due to the thermal impact was observed. Hence, this blackening seems to be related mainly to the presence of calomel (Hg2Cl2) and a gypsum (CaSO4·2H2O) crust as degradation products of red cinnabar and the calcite mortar, respectively, and not to the formation of metacinnabar. Finally, laser-based techniques could also induce modifications in the HgS crystalline structure, resulting in an amorphous black product. Therefore, the elemental and molecular study of the species promoted by laser impact was carried out to avoid false positives in the metacinnabar detection or when the decorated surface has been subjected to laser cleaning.
Graphical Abstract
Extending periodic maps on surfaces over the 4-sphere
Authors: Wang Shicheng , Wang Zhongzi 
Published: October 2022

Let [Formula: see text] be the closed orientable surface of genus [Formula: see text]. We address the problem to extend torsion elements of the mapping class group [Formula: see text] over the 4-sphere [Formula: see text]. Let [Formula: see text] be a torsion element of maximum order in [Formula: see text]. Results including: (1) For each [Formula: see text], [Formula: see text] is periodically extendable over [Formula: see text] for some non-smooth embedding [Formula: see text], and not periodically extendable over [Formula: see text] for any smooth embedding [Formula: see text]. (2) For each [Formula: see text], [Formula: see text] is extendable over [Formula: see text] for some smooth embedding [Formula: see text] if and only if [Formula: see text]. (3) Each torsion element of order [Formula: see text] in [Formula: see text] is extendable over [Formula: see text] for some smooth embedding [Formula: see text] if either (i) [Formula: see text] and [Formula: see text] is even; or (ii) [Formula: see text] and [Formula: see text]; or (iii) [Formula: see text]. Moreover, the conditions on [Formula: see text] in (i) and (ii) cannot be removed.
Direction-optimizing Label Propagation Framework for Structure Detection in Graphs: Design, Implementation, and Experimental Analysis
Authors: Liu Xu , Lumsdaine Andrew , Halappanavar Mahantesh , Barker Kevin , Gebremedhin Assefaw 
Published: October 2022

Label Propagation is not only a well-known machine learning algorithm for classification but also an effective method for discovering communities and connected components in networks. We propose a new Direction-optimizing Label Propagation Algorithm (DOLPA) framework that enhances the performance of the standard Label Propagation Algorithm (LPA), increases its scalability, and extends its versatility and application scope. As a central feature, the DOLPA framework relies on the use of
frontiers
and alternates between label
push
and label
pull
operations to attain high performance. It is formulated in such a way that the same basic algorithm can be used for finding communities or connected components in graphs by only changing the objective function used. Additionally, DOLPA has parameters for tuning the processing order of vertices in a graph to reduce the number of edges visited and improve the quality of solution obtained. We present the design and implementation of the enhanced algorithm as well as our shared-memory parallelization of it using OpenMP. We also present an extensive experimental evaluation of our implementations using the LFR benchmark and real-world networks drawn from various domains. Compared with an implementation of LPA for community detection available in a widely used network analysis software, we achieve at most five times the F-Score while maintaining similar runtime for graphs with overlapping communities. We also compare DOLPA against an implementation of the Louvain method for community detection using the same LFR-graphs and show that DOLPA achieves about three times the F-Score at just 10% of the runtime. For connected component decomposition, our algorithm achieves orders of magnitude speedups over the basic LP-based algorithm on large-diameter graphs, up to 13.2× speedup over the Shiloach-Vishkin algorithm, and up to 1.6× speedup over Afforest on an Intel Xeon processor using 40 threads.
Inhibition of Wnt Signaling in Colon Cancer Cells via an Oral Drug that Facilitates TNIK Degradation
Authors: Zhou Kun , Cheong Jae Eun , Krishnaji Subrahmanian Tarakkad , Ghalali Aram , Fu Haojie , Sui Lufei , Alix-Panabières Catherine , Cayrefourcq Laure , Bielenberg Diane , Sun Lijun , Zetter Bruce 
Published: October 2022

Abstract
We have synthesized an oxetane derivative of the benzimidazole compound mebendazole (OBD9) with enhanced solubility and strong anticancer activity in multiple types of cancer cells, especially colorectal cancer. In this report, we provide evidence that OBD9 suppresses colorectal cancer growth by interfering with the Wnt signaling pathway, a main driver of cell growth in colorectal cancer. Specifically, we find that OBD9 induces autophagic degradation of TNIK (traf2 and Nck-interacting kinase), which promotes T-cell factor-4 (TCF4)/beta-catenin–mediated gene expression. Thus, OBD9 as a TNIK inhibitor blocks Wnt/beta-catenin signaling at the final step of transcriptional activation. We suggest that OBD9 provides a potential novel autophagy-mediated, Wnt-damping therapeutic strategy for the treatment of colorectal cancer.
Distinct Mechanisms of Mismatch-Repair Deficiency Delineate Two Modes of Response to Anti–PD-1 Immunotherapy in Endometrial Carcinoma
Authors: Chow Ryan D. , Michaels Tai , Bellone Stefania , Hartwich Tobias M.P. , Bonazzoli Elena , Iwasaki Akiko , Song Eric , Santin Alessandro D. 
Published: October 2022

Abstract

Mismatch repair–deficient (MMRd) cancers have varied responses to immune-checkpoint blockade (ICB). We conducted a phase II clinical trial of the PD-1 inhibitor pembrolizumab in 24 patients with MMRd endometrial cancer (NCT02899793). Patients with mutational MMRd tumors (6 patients) had higher response rates and longer survival than those with epigenetic MMRd tumors (18 patients). Mutation burden was higher in tumors with mutational MMRd compared with epigenetic MMRd; however, within each category of MMRd, mutation burden was not correlated with ICB response. Pretreatment JAK1 mutations were not associated with primary resistance to pembrolizumab. Longitudinal single-cell RNA-seq of circulating immune cells revealed contrasting modes of antitumor immunity for mutational versus epigenetic MMRd cancers. Whereas effector CD8+ T cells correlated with regression of mutational MMRd tumors, activated CD16+ NK cells were associated with ICB-responsive epigenetic MMRd tumors. These data highlight the interplay between tumor-intrinsic and tumor-extrinsic factors that influence ICB response.

Significance:
The molecular mechanism of MMRd is associated with response to anti–PD-1 immunotherapy in endometrial carcinoma. Tumors with epigenetic MMRd or mutational MMRd are correlated with NK cell or CD8+ T cell–driven immunity, respectively. Classifying tumors by the mechanism of MMRd may inform clinical decision-making regarding cancer immunotherapy.
This article is highlighted in the In This Issue feature, p. 247
Assessment of Patterns of Atherectomy Use
Authors: Brown Craig S. , Eton Ryan E. , Yaser Jessica M. , Syrjamaki John D. , Corriere Matthew A. , Henke Peter K. , Englesbe Michael J. , Osborne Nicholas H. 
Published: October 2022

Background
Atherectomy has become the fastest growing catheter‐based peripheral vascular intervention performed in the United States, and overuse has been linked to increased reimbursement, but the patterns of use have not been well characterized.

Methods and Results

We used Blue Cross Blue Shield of Michigan Preferred Provider Organization and Medicare fee‐for‐service professional claims data from the Michigan Value Collaborative for patients undergoing office‐based laboratory atherectomy in 2019 to calculate provider‐specific rates of atherectomy use, reimbursement, number of vessels treated, and number of atherectomies per patient. We also calculated the rate that each provider converted a new patient visit to an endovascular procedure within 90 days. Correlations between parameters were assessed with simple linear regression. Providers completing ≥20 office‐based laboratory atherectomies and ≥20 new patient evaluations during the study period were included. A total of 59 providers performing 4060 office‐based laboratory atherectomies were included. Median professional reimbursement per procedure was $4671.56 (interquartile range [IQR], $2403.09–$7723.19) from Blue Cross Blue Shield of Michigan and $14 854.49 (IQR, $9414.80–$18 816.33) from Medicare, whereas total professional reimbursement from both payers ranged from $2452 to $6 880 402 per year. Median 90‐day conversion rate was 5.0% (IQR, 2.5%–10.0%), whereas the median provider‐level average number of vessels treated per patient was 1.20 (IQR, 1.13–1.31) and the median provider‐level average number of treatments per patient was 1.38 (IQR, 1.26–1.63). Total annual reimbursement for each provider was directly correlated with new patient‐procedure conversion rate (
R
2
=0.47;
P
<0.001), mean number of vessels treated per patient (
R
2
=0.31;
P
<0.001), and mean number of treatments per patient (
R
2
=0.33;
P
<0.001).

Conclusions
A minority of providers perform most procedures and are reimbursed substantially more per procedure compared with most providers. Procedural conversion rate, number of vessels, and number of treatments per patient represent potential policy levers to curb overuse.
On the Natural History of Coronary Artery Disease: A Longitudinal Nationwide Serial Angiography Study
Authors: Mohammad Moman A. , Stone Gregg W. , Koul Sasha , Olivecrona Göran K. , Bergman Sofia , Persson Jonas , Engstrøm Thomas , Fröbert Ole , Jernberg Tomas , Omerovic Elmir , James Stefan , Bergström Göran , Erlinge David 
Published: October 2022

Background
The long‐term course of coronary atherosclerosis has not been studied in large nationwide cohorts. Understanding the natural history of coronary atherosclerosis could help identify patients at risk for future coronary events.

Methods and Results
All coronary artery segments with <50% luminal stenosis in patients with a first‐time coronary angiogram between 1989 and 2017 were identified (n=2 661 245 coronary artery segments in 248 736 patients) and followed until a clinically indicated angiography within 15 years was performed or until death or end of follow‐up (April 2018) using SCAAR (Swedish Coronary Angiography and Angioplasty Registry). The stenosis progression and incidence rates were 2.6% and 1.45 (95% CI, 1.43–1.46) per 1000 segment‐years, respectively. The greatest progression rate occurred in the proximal and middle segments of the left anterior descending artery. Male sex and diabetes were associated with a 2‐fold increase in risk, and nearly 70% of new stenoses occurred in patients with baseline single‐vessel disease (hazard ratio, 3.86 [95% CI, 3.69–4.04]). Coronary artery segments in patients with no baseline risk factors had a progression rate of 0.6% and incidence rate of 0.36 (95% CI, 0.34–0.39), increasing to 8.1% and 4.01 (95% CI, 3.89–4.14) per 1000 segment‐years, respectively, in patients with ≥4 risk factors. The prognostic impact of risk factors on stenosis progression was greatest in younger patients and women.

Conclusions
Coronary atherosclerosis progressed slowly but more frequently in the left coronary artery in men and in the presence of traditional risk factors. Coronary artery segments in patients without risk factors had little or no risk of stenosis progression, and the relative impact of risk factors appears to be of greater importance in younger patients and women. These findings help in the understanding the long‐term course of coronary atherosclerosis.