bluuebunny/crossref_metadata_2025_split huggingface dataset:
Properties of Additive-Manufactured Open Porous Titanium Structures for Patient-Specific Load-Bearing Implants
Authors: Zumofen Livia , Kopanska Katarzyna S. , Bono Epifania , Kirchheim Andreas , De Haller Emmanuel B. , Graf-Hausner Ursula 
Published: February 2022

Additive manufacturing has been well established in many sectors, including the medical industry. For load-bearing bone implants, titanium and its alloys, such as Ti6Al4V, are widely used due to their high strength to weight ratio and osseointegrative properties. However, bone resorption and loosening of implants is related to the significantly higher stiffness of dense Ti6Al4V, leading to stress shielding. With the aging of population, there is an increasing need for orthopedic implants with a high success rate and a long implant life span. Besides that the treatment of non-healing segmental bone defects, where the self-repairing properties of bone tissue are not sufficient, is still a challenge. In both fields of application, patient-specific titanium implants combined with functionally graded porosity designed according to locally expected loads unlock new possibilities. Many studies underline the huge potential of the new design freedom to generate open porous structures and more personalized implants with enhanced mechanical properties that also integrate well with surrounding tissues. Integration of functionally graded open porosity into implants allows for the implant to more closely mimic the mechanical properties of human bone and its internal architecture. The results of this work represent the basis for developing complex porous titanium structures with various pore sizes and shapes to tailor structural mechanical properties and biological responses. Therefore, 3D porous structures with various pore sizes and shapes were designed and manufactured in Ti6Al4V using laser powder bed fusion (PBF-LB/M). Based on these structures, the correlation of pore size and shape with cell ingrowth, morphology, metabolic activity, and early markers for bone formation (ALP activity) was investigated in static cell cultures using the osteosarcoma cell line Saos-2. Mechanical properties, such as stiffness and compression strength, were investigated with compression testing. The present study concludes that cell morphology, metabolic activity, and ALP activity are widely independent of pore shape and size within the tested range of 400–700 µm pore size. Furthermore, the mechanical properties of the evaluated structures were in the range of cortical and trabecular bone. This opens the possibility to design mechanical properties with gradient porosity without decisively affecting biological responses.
Deletion of Wild-type p53 Facilitates Bone Metastatic Function by Blocking the AIP4 Mediated Ligand-Induced Degradation of CXCR4
Authors: Li Qiji , Wang Min , Zeng Leli , Guo Wei , Xu Yuandong , Li Chenxin , Lai Yingrong , Ye Liping , Peng Xinsheng 
Published: February 2022

Background: Management of patients with prostate cancer and bone metastatic disease remains a major clinical challenge. Loss or mutation of p53 has been identified to be involved in the tumor progression and metastasis. Nevertheless, direct evidence of a specific role for wild-type p53 (wt-p53) in bone metastasis and the mechanism by which this function is mediated in prostate cancer remain obscure.Methods: The expression and protein levels of wt-53, AIP4, and CXCR4 in prostate cancer cells and clinical specimens were assessed by real-time PCR, immunohistochemistry and western blot analysis. The role of wt-p53 in suppressing aggressive and metastatic tumor phenotypes was assessed using in vitro transwell chemotaxis, wound healing, and competitive colocalization assays. Furthermore, whether p53 deletion facilitates prostate cancer bone-metastatic capacity was explored using an in vivo bone-metastatic model. The mechanistic model of wt-p53 in regulating gene expression was further explored by a luciferase reporter assay and chromatin immunoprecipitation (ChIP) assay.Results: Our findings revealed that wt-p53 suppressed the prostate cancer cell migration rate, chemotaxis and attachment toward the osteoblasts in vitro. The bone-metastatic model showed that deletion of wt-p53 remarkably increased prostate cancer bone-metastatic capacity in vivo. Mechanistically, wt-p53 could induce the ligand-induced degradation of the chemokine receptor CXCR4 by transcriptionally upregulating the expression of ubiquitin ligase AIP4. Treatment with the CXCR4 inhibitor AMD3100 or transduction of the AIP4 plasmid abrogated the pro-bone metastasis effects of TP53 deletion.Conclusion: Wt-p53 suppresses the metastasis of prostate cancer cells to bones by regulating the CXCR4/CXCL12 activity in the tumor cells/bone marrow microenvironment interactions. Our findings suggest that targeting the wt-p53/AIP4/CXCR4 axis might be a promising therapeutic strategy to manage prostate cancer bone metastasis.
Relaxation, Percolation, and Non-Spontaneous Fluctuation of Linguistic Behavior in a Quasi-Isolated System
Authors: Tilsen Sam 
Published: February 2022

Linguistic behaviors arise from strongly interacting, non-equilibrium systems. There is a wide range of spatial and temporal scales that are relevant for the analysis of speech. This makes it challenging to study language from a physical perspective. This paper reports on a longitudinal experiment designed to address some of the challenges. Linguistic and social preference behavior were observed in an ad-hoc social network over time. Eight people participated in weekly sessions for 10 weeks, playing a total of 535 map-navigation games. Analyses of the degree of order in social and linguistic behaviors revealed a global relaxation toward more ordered states. Fluctuations in linguistic behavior were associated with social preferences and with individual interactions.
Total Mesorectal Excision vs. Transanal Endoscopic Microsurgery Followed by Radiotherapy for T2N0M0 Distal Rectal Cancer: A Multicenter Randomized Trial
Authors: Tang Junwei , Zhang Yue , Zhang Dongsheng , Zhang Chuan , Jin Kangpeng , Ji Dongjian , Peng Wen , Feng Yifei , Sun Yueming 
Published: February 2022

IntroductionTransanal endoscopic microsurgery (TEM) is an organ-preserving treatment alternative for patients with early rectal cancer. However, TEM alone is associated with greater risk of local recurrence and inferior survival in comparison with total meso-rectal excision (TME). As an important adjuvant therapy, radiotherapy can effectively reduce the local recurrence rate of rectal cancer. This study aimed to investigate whether TEM followed by radiotherapy can be a valid alternative to TME in T2N0M0 distal rectal cancer treatment.MethodsWe plan to recruit 168 participants meeting established inclusion criteria. Following informed consent, participants will randomly receive treatment protocols of TEM followed by radiotherapy (a total dose of 45–50.4 Gy given in 25–28 factions) or TME. Depending on post-operative pathology, the participants will receive either long-term follow-up or further treatment. The primary endpoint of this trial is 3-year local recurrence rate. The secondary end points include 3-year disease-free survival rate, 3-year overall survival rate, 3-year mortality rate, post-operative quality of life, post-operative safety index, intraoperative evaluation index and post-operative short-term evaluation index.DiscussionThis trial is the first prospective randomized trial to investigate the rectum preserving treatment by using transanal local excision followed by radiotherapy.Clinical trial registrationThe trial was prospectively registered at ClinicalTrials.gov NCT04098471 on September 20, 2019.
The Shared Safety Net Action Plan (SSNAP): a co-designed intervention to reduce delays in cancer diagnosis
Authors: Heyhoe Jane , Reynolds Caroline , Bec Remi , Wolstenholme Daniel , Grindell Cheryl , Louch Gemma , Lawton Rebecca 
Published: February 2022

BackgroundSafety netting in primary care may help diagnose cancer earlier, but it is unclear what the format and content of an acceptable safety-netting intervention would be. This project aimed to co-design a safety-netting intervention with and for primary care patients and staff.AimThis work sought to address how a safety-netting intervention would be implemented in practice; and, if and how a safety-netting intervention would be acceptable to all stakeholders.Design and settingPatient representatives, GPs, and nurse practitioners were invited to a series of co-design workshops. Patients who had and had not received a diagnosis of cancer and primary care practices took part in separate focus groups.MethodThree workshops using creative co-design processes developed the format and content of the intervention prototype. The COM-B Framework underpinned five focus groups to establish views on capability, opportunity, and motivation to use the intervention to assist with prototype refinement.ResultsWorkshops and focus groups suggested the intervention format and content should incorporate visual and written communication specifying clear timelines for monitoring symptoms and when to present back; be available in paper and electronic forms linked to existing computer systems; and be able to be delivered within a 10-minute consultation. Intervention use themes included ‘building confidence through partnership’, ‘using familiar and current procedures and systems’, and ‘seeing value’.ConclusionThe Shared Safety Net Action Plan (SSNAP) — a safety-netting intervention to assist the timely diagnosis of cancer in primary care, was successfully co-designed with and for patients and primary care staff.
Kemampuan Pemecahan Masalah Matematis dalam Menyelesaikan Soal Cerita Ditinjau dari Langkah- Langkah Polya Materi Bangun Ruang Madrasah Ibtidaiyah
Authors: Alfiandari Lely , Alman Alman , Sahidi Sahidi 
Published: February 2022

Penelitian ini bertujuan untuk menganalisis kemampuan pemecahan masalah matematis peserta didik dalam menyelesaikan soal cerita ditinjau dari langkah-langkah polya pada materi bangun ruang kelas VI. Jenis penelitian ini adalah deskriptif kualitatif dengan Teknik pengumpulan data adalah tes, wawancara, dan dokumentasi. Subjek penelitian dipilih melalui teknik purposive sampling sehigga diperoleh peserta didik Kelas VI MI Sains Al-Hidayah dengan jumlah 6 orang. Analisis data meliputi pengumpulan data, reduksi, penyajian, dan penarikan kesimpulan. Hasil penelitian diperoleh bahwa kemampuan pemecahan masalah matematis peserta didik dalam kategori tinggi adalah mampu memahami masalah, mampu merencanakan penyelesaian, mampu menyelesaikan masalah, tetapi mengalami sedikit kesulitan dalam mengecek kembali. Kemampuan pemecahan kategori sedang yakni mampu memahami masalah yang diketahui dan ditanyakan dalam soal, kurang mampu merencanakan masalah, meskipun salah dalam melaksanakan rencana penyelesaian namun tidak melakukan kesalahan perhitungan, dan belum mampu dalam melihat kembali hasil penyelesaiannya. Sedangkan kemampuan pemecahan masalah kategori rendah belum mampu memahami masalah, merencanakan penyelesaian, melaksanakan rencana penyelesaian dan belum mampu mengecek kembali hasil yang diperoleh. Kesimpulannya adalah kemampuan pemecahan masalah matematis peserta didik dalam menyelesaikan soal cerita ditinjau dari langkah-langkah polya dianalisis dengan tiga kemampuan yakni Tinggi, Sedang dan rendah.
Use of Quizizz In Improving Students' Reading Skill
Authors: Pradnyadewi Diah Ayu Manik , Kristiani Putu Enik 
Published: February 2022

Using various learning media in teaching reading are need to avoid the monotonous learning activities which make students easily bored. With increasingly sophisticated technological developments, teachers can apply the Quizizz application as learning media to improve students’ reading skill. The Quizizz application has characteristics such as avatars, themes, memes, and music which are very entertaining in the learning process. At the time they play the game, actually they are reading a lot and learning to understand the meaning of the reading. In addition, the Quizizz Application also has timely feedback, a review section, and repeats tests and follows new quizzes. This literature study reviews some papers in studying the implications of Quizziz and its advantages. The aim of this paper is to share the use of Quizizz Application in improving students reading skill. The findings of this study are expected can be an alternative learning media used by both teacher and students in supporting teaching and learning process in reading.
Motivation as Contributing Factor That Impacts Teaching Excellence in Learning
Authors: Dipa Putu Sora 
Published: February 2022

Motivation is known as a dynamic and complex thing that provides an important role in learning related to success and failure. There are many factors that greatly influence the quality of teaching motivation. The quality of teaching will be important in the learning process in various ways in education. Education is an important part of the learning process. Commitment and sincerity are things that should be considered in shaping learning patterns to achieve improvement and change. One of the factors that can influence the learning process is motivation. Teaching motivation is usually influenced by a lot of knowledge and experience from someone so that the topic or information provided can be conveyed properly. This article will explain the various factors that can improve the quality of teaching motivation that influences education and learning.

Keywords: Education, Learning, Teaching Motivation
Hubungan Pengasuh Anak dengan Perkembangan Personal Sosial Anak Usia 4 – 6 Tahun di Tk Aisyiah Kota Kupang
Authors: Yurissetiowati  
Published: February 2022

Anak usia dini adalah anak yang berada pada rentang usia 0-6 tahun. Anak usia dini mempunyai perkembangan sangat pesat. Berdasarkan hasil penelitian, sebesar 40% dari perkembangan manusia terjadi pada usia dini sehingga usia dini dipandang sangat penting dan diistilahkan sebagai usia emas. Perkembangan anak sangat dipengaruhi oleh faktor keluarga. Terdapat banyak faktor yang dapat mempengaruhi perkembangan anak usia 4 – 6 tahun salah satunya adalah pengasuh anak. Tujuan dari penelitian ini adalah untuk mengetahui hubungan pengasuh anak dengan perkembangan personal sosial anak usia 4 – 6 tahun di TK Aisyiah Kota Kupang. Penelitian ini menggunakan studi analitik dengan pendekatan cross sectional. Populasi penelitian adalah seluruh anak usia 4 - 6 tahun di TK Aisyiah Kota Kupang tahun 2019. Sampel penelitian ini sejumlah 74 responden. Pengumpulan data dilakukan dengan menggunakan kuesioner dan lembar observasi DDST. Penelitian ini menggunakan uji Chi- Square . Hasil penelitian menunjukkan pengasuh anak memiliki nilai p-value > 0,05 (p-value = 0,604) yang artinya bahwa tidak ada hubungan signifikan antara faktor pengasuh anak dengan perkembangan personal sosial anak usia 4-6 tahun. Simpulan Tidak ada hubungan yang positif dan signifikan antara pengasuh anak dengan perkembangan personal sosial anak usia 4-6 tahun di TK Aisyiah Kota Kupang
Best Practices for Virtual Care: A Consensus Statement From the Canadian Rheumatology Association
Authors: Barber Claire E.H. , Levy Deborah M. , Ahluwalia Vandana , Mendel Arielle , Taylor-Gjevre Regina , Gerschman Tommy , Koppikar Sahil , Jilkine Konstantin , Stringer Elizabeth , Barnabe Cheryl , Aydin Sibel Zehra , Luca Nadia , Berard Roberta , Tam Keith , Burt Jennifer , Murdoch Jocelyne C. , Zinck Graeme , Lane Therese , Heeley Jennifer , Mannerow Megan , Mills Renee , Wilhelm Linda , Hartfeld Nicole M.S. , Ohata Brent 
Published: February 2022

ObjectiveTo develop best practice statements for the provision of virtual care in adult and pediatric rheumatology for the Canadian Rheumatology Association’s (CRA) Telehealth Working Group (TWG).MethodsFour members of the TWG representing adult, pediatric, university-based, and community rheumatology practices defined the scope of the project. A rapid literature review of existing systematic reviews, policy documents, and published literature and abstracts on the topic was conducted between April and May 2021. The review informed a candidate set of 7 statements and a supporting document. The statements were submitted to a 3-round (R) modified Delphi process with 22 panelists recruited through the CRA and patient advocacy organizations. Panelists rated the importance and feasibility of the statements on a Likert scale of 1–9. Statements with final median ratings between 7–9 with no disagreement were retained in the final set.ResultsTwenty-one (95%) panelists participated in R1, 15 (71%) in R2, and 18 (82%) in R3. All but 1 statement met inclusion criteria during R1. Revisions were made to 5/7 statements following R2 and an additional statement was added. All statements met inclusion criteria following R3. The statements addressed the following themes in the provision of virtual care: adherence to existing standards and regulations, appropriateness, consent, physical examination, patient-reported outcomes, use in addition to in-person visits, and complex comanagement of disease.ConclusionThe best practice statements represent a starting point for advancing virtual care in rheumatology. Future educational efforts to help implement these best practices and research to address identified knowledge gaps are planned.
Optimization strategies for the integrated management of perishable supply chains: A literature review
Authors: Mirabelli Giovanni , Solina Vittorio 
Published: February 2022

Purpose: The main purpose of this article is to systematically review the papers published in the period 2005-2020 about the integration of production, inventory and distribution activities in perishable supply chains.Design/methodology/approach: The proposed research methodology is based on several steps. First, database and keywords are selected, with the aim to search and collect the main papers, dealing with the integration of production, inventory, distribution activities in perishable supply chains. Then, a bibliometric analysis is carried out, to detect: the main publishing sources, the chronological distribution, the most used keywords, the featured authors, about the selected papers. A five-dimension classification framework is proposed to carry out a content analysis, where the papers of the literature review are classified and discussed, according to: supply chain structure, objective, perishability issues, solution approach, approach validation. Findings: Interest in the application of optimization models for integrated decision-making along perishable supply chains is strongly growing. Integrating multiple stages of the supply chain into a single framework is complex, especially when referring to perishable products. The vast majority of the problems addressed are then NP-Hard. Only a limited quantity of the selected papers aims to solve real-life case studies. There is a need for further research, which is capable of modeling and quantitatively improving existing supply chains. The potentials of Industry 4.0 are currently little explored. Originality/value: Based on the analysis of the papers published, this article outlines the current state of the art on the optimization strategies for the integrated management of perishable supply chains, which are very complex to be managed. Research trends and gaps are discussed, future challenges are presented.
A New Learning Approach to Improve Nurses' Knowledge of and Skills in Diabetes Care
Authors: Liao Hui-Chuan , Liang Wen-Miin , Chu Chien-Lun , Huang Li-Chi 
Published: February 2022

Background:
Patients' knowledge of how to care for their diabetes mellitus (DM) is critically influenced by health education, which is mostly provided by nurses. Therefore, effectively increasing nurses' knowledge of and skills in diabetes care is crucial. The aim of this study was to explore the effectiveness of the Diabetes Conversation Map™ Program (DCMP) in improving nurses' knowledge of DM care and skills in insulin injection.

Method:
A quasi-experimental design was adopted that used a pre-test and a posttest. A total of 18 nurses were included in the intervention group, while 19 nurses were in the control group receiving conventional teaching. A structured questionnaire regarding knowledge of and skills in DM care was administered before the program and then one month after.

Results:

Knowledge of DM and skills in insulin injection improved significantly in the intervention group compared to the control group (
p
< .001 vs.
p
< .01).

Conclusion:

The DCMP can be used to increase nurses' knowledge of DM and their skills in caring for DM. It leads to more effective learning than conventional teaching.

[
J Contin Educ Nurs
. 2022;53(2):90–96.]
Vasculitis livedoide asociada a mononeuritis múltiple
Authors: Roverano Susana , Ortiz Alberto , Martínez Carlos , Langhi Juan Carlos , Paira Sergio 
Published: February 2022

Se presenta un varón de 64 años, obeso, hipertenso, con diabetes no-insulinodependiente de 6 años de evolución. Se presentó a la consulta con úlceras dolorosas en miembros inferiores de aparición estival, de 10 meses de evolución y relataba parestesias de 20 meses de evolución. La electromiografía reveló la presencia de una mononeuritis múltiple que luego progresó a polineuropatía axonal mixta. Necrosis dérmica asociada a trombos ﬁbrinoides, depósitos de material hialino con inﬁltrado inﬂamatorio mixto fue observado en la biopsia de piel, llegándose al diagnóstico de vasculitis livedoide. La misma no sería una verdadera vasculitis, sino un fenómeno vaso-oclusivo que debe diferenciarse de otras vasculitis (vasculitis cutáneas de pequeños vasos, panarteritis nodosa, síndrome anti-fosfolipídico, estasis venoso crónico, pioderma gangrenoso, entre otros). El compromiso neurológico es excepcional en esta vasculopatía, habiendo sido descriptos sólo 5 casos con esta asociación.
Características clínicas y demográficas de sujetos con patologías reumáticas ingresados a rehabilitación: estudio descriptivo retrospectivo
Authors: Abudarham Julia , Dilascio Sofía Anabela , Gallo Sabrina , Kramer Marcia Daiana , Maiarú Mariano , Ostolaza Marco , Sanchez Correa Cecilia Mariel 
Published: February 2022

Antecedentes: Las enfermedades reumáticas (ER) son afecciones que comprometen al sistema musculoesquelético y existen más de 100 tipos. Los autores de este estudio no encontramos antecedentes que describan características de los sujetos con ER admitidos en un servicio de rehabilitación en Argentina.
Objetivo: Describir y analizar una muestra de sujetos con ER ingresados en el Servicio de Kinesiología del Instituto de Rehabilitación Psicofísica (I.Re.P.) de la Ciudad Autónoma de Buenos Aires entre enero de 2010 y diciembre de 2015.
Peculiarities of nurses work for nursing patients with chronic leg ulcers
Authors: Čerkauskaitė Sonata , Česnauskienė Audronė 
Published: February 2022

Legs ulcers are one of the most difficult Problem to solve in modern medicine. Although a wide variety of drugs and mechanical methods have been developed to treat ulcers, no marked improvement has yet been discovered in either wound healing or the social status of patients. Leg ulcers are not only a common, difficult to treat, but also economically unprofitable health condition requiring a lot of care, work and knowledge.
Study aim – to evaluate peculiarities of nurses work for nursing patients with chronic leg ulcers.
Study methods. Quantitative research method using an anonymous questionnaire for nurses caring for patients with chronic leg ulcers. Descriptive statistics of results.
Results. Nurses working in a hospital at least once a week care for patients with chronic leg ulcers, which are usually localized in the calf, foot, ankle areas. Patients with other comorbid conditions (e. g. diabetes, arterial hypertension and other) are needed specific nursing needs – longer wound healing, prevention of infections and bleeding, balanced diet and temperature control. Nursing patients with chronic leg ulcers the body position of the nurses mostly is forced, they work bent over. The work of nurses is most complicated by the lack of nursing assistants.