bluuebunny/crossref_metadata_2025_split huggingface dataset:
Chain Mediating Effect of Self-control and Problem Behavior on Depression among Adolescents
Authors: Jiang Maoming , Gao Kai , Wu Zhengyu , Guo Peipei 
Published: May 2022

Abstract
Depression has become a prominent psychological problem among young people. The purpose of this study was to investigate the potential relationship between Internet addiction, family climate, academic performance, self-control, behavioral biases and depressive symptoms in adolescents. Based on the survey data of the fifth wave (2017 ~ 2018) and the sixth wave (2019 ~ 2020) of the China Family Panel Studies (CFPS), this study used LISREL8.8 software to analyze 1577 10 ~ 15 data on adolescents. In this study, selected individuals responded to the same depressive symptoms-related questions in both waves of the survey. The study found that Internet addiction had no direct effect on depressive symptoms in adolescents. Family atmosphere was negatively correlated with depressive symptoms. Academic performance was positively associated with depressive symptoms. Mediating effects found that Internet addiction, family climate, and academic performance can indirectly affect depressive symptoms through the independent mediation of behavioral deviations and the chain mediation of self-control and behavioral deviations. This study also found depressive symptoms in adolescents have a certain persistence in time. Based on this study, it is necessary to pay more attention to the depression of adolescents, strengthen the training of self-control, improve the anti-frustration ability and psychological resilience, and reduce the problem behavior of adolescents. It is recommended to try to start from emotional self-regulation to promote the personality health of adolescents.
Echinococcus multilocularis protoscoleces enhance glycolysis to promote M2 Macrophages through PI3K/Akt/mTOR Signaling Pathway
Authors: Zhang Tao , Zhang Yaogang , Yang Zihan , Jiang Yuan , Sun Li , Huang Dengliang , Tian Meiyuan , Shen Yinhong , Deng Jun , Hou Jin , Ma Yanyan 
Published: May 2022

Abstract
Background: Alveolar Echinococcosis (AE) is a zoonotic parasitic disease caused by Echinococcus multilocularis, but its pathogenesis remains unclear. The primary objective of this study is to explore whether Echinococcus multilocularis protoscoleces (PSCs) regulate macrophage polarization and glucose metabolism by PI3K/Akt/mTOR signaling pathway.Methods: Macrophage polarization were analyzed by flow cytometry, PI3K, Akt, pAKT, and mTOR were detected by western blot, and cell metabolic was analyzed by seahorse.Results: Large numbers of CD68+ macrophages gathered in close liver issue from the lesion in AE patients. PSCs preferentially differentiated into M2 macrophages and the expressions of HK1, PFKL, PKM2, PI3K, pAKT, and mTOR increased with the extension of co-culture time.Conclusions: Echinococcus multilocularis protoscoleces enhance glycolysis to promote M2 macrophages through PI3K/Akt/mTOR signaling pathway.
Association of PFKM Gene Polymorphisms and Susceptibility to Cryptorchidism in a Chinese Han Population
Authors: Long Si-Yu , Ran Zhang , Yang Qin-Ni , Wang Yan-Yun , Song Ya-Ping , Zhou Bin , Zhang Lin 
Published: May 2022

Abstract
Cryptorchidism is one of the most common congenital anomalies in newborn boys. There are various risk factors that have been verified to have relationship with cryptorchidism, including exogenous and genetic, but the pathogenesis of cryptorchidism remains unclear. PFKM gene is a critical gene encodes for a regulatory enzyme, which limits the rate in the pathway of glycolysis. In order to investigate the possible association between PFKM gene polymorphisms and cryptorchidism risk, 3 tag SNPs of PFKM gene, rs2228500 (A/G), rs4075913(A/G), and rs11168417(C/T) were selected and genotyped in a hospital-based case-control study involving 140 cryptorchidism patients and 227 healthy controls. The frequency of allele G of SNP rs2228500 is increased in cryptorchidism patients compared to that in controls (p < 0.05). Genotypic frequencies of rs2228500 are associated with the susceptibility of cryptorchidism in the codominant model (p < 0.05). And compared with G/G genotype in the dominant model, notable decreased frequencies of A carriers (A/G-A/A genotypes) were observed in cryptorchidism patients (p = 0.0069, OR = 1.80, 95% CI =1.17-2.75). This research firstly revealed that PFKM gene polymorphisms were associated with cryptorchidism in a Chinese Han population.
Health and Peacebuilding in Colombia: challenges and opportunities of a community training process for the post-accord
Authors: González-Uribe Catalina , Simbaqueba Melissa Arena , León-Giraldo Sebastián , Arias-Gómez Luis F. , Rodríguez David Alejandro , Hernández-Neuta Ginna Esmeralda , Moreno-Serra Rodrigo , Bernal Oscar 
Published: May 2022

Abstract
Following the peace agreement process in Colombia and to guarantee the right to health, a national educational program to train community leaders in technical education in public health was designed and implemented. Using qualitative methodologies, we sought reflections about the impact of the training process on the 'participant's life projects, collecting information from previous and current experiences and expectations after the program. Participants (n = 44) included peasants, afro-Colombian and indigenous communities, displaced people, victims of the armed conflict, and ex-combatants of the Revolutionary Armed Forces of Colombia - Army of the People (FARC-EP). Data collection through ethnographic observation, focus groups, and individual semi-structured interviews took place between October and November 2018. Results indicate that the participants saw the program as an opportunity to meet their goals and have better opportunities for their lives; change their way of thinking, and be reflective and open to discussion. Historical governmental and institutional abandonment was identified as a barrier for trust in the program and uncertainty on its potential benefits. Daily life co-existence during the training was a challenge between participants given their diverse backgrounds in the context of conflict in Colombia. It is important to create friendly and explanatory strategies to generate trust with and among participants accompanied with psychological support, ease successful interaction, and generate wellbeing through the program's implementation.
Exploring the Antecedents of Technostress at Work: A Meta-Analysis
Authors: Kotek Magdalena , Vranjes Ivana 
Published: May 2022

Abstract
Technostress, one of the adverse consequences of technology use, has been in the forefront of recent scientific investigations. Drawing on Tarafdar et al. ‘s (2007) framework, this study consolidated available information on personal, environmental and technology factors that lead to technostress perceptions at work: techno-complexity, techno-insecurity, techno-invasion, techno-overload and techno-uncertainty. We conducted a random-effects meta-analysis of quantitative primary studies that investigated predictors of these five technostress dimensions. Systematic database searches (Web of Science, Scopus and PsychInfo), backward searches and announcements yielded 482 unique studies. We identified 21 eligible studies and extracted 254 effect sizes concerning individual differences, technological characteristics, and the organisational environment. Our results suggest that a multitude of predictors is involved in the manifestation of technostress, whereas the most prominent meta-analytic summary effects concern mindfulness, perceived complexity/effort and required technology usage. These findings imply that individual differences expose employees differently to technostress and establish technological features as well as the organisational context as determining forces in technostress formation. Yet, the dispersion of available research has led to very small subsets for analysis and subjected this study to limitations that manifested as imprecise summary effects. The current study was pre-registered on aspredicted.org (#67112).
Treatment of Extramedullary Plasmacytoma of the Rectum with Endoscopic Mucosal Resection: A Case Report and Literature Review
Authors: Fan Ling , Fu Yan , Liu Yi , Huang Hua 
Published: May 2022

Abstract
Purpose Extramedullary plasmacytoma (EMP) is an unusual plasma cell disease.We report a case of EMP arising in the rectum, which is fully removed using endoscopic mucosal resection (EMR).Methods The patient’s clinical, endoscopic, and histologic data were reviewed, as well as the past literature of rectal EMP with a focus on the clinical presentation, treatment and outcome.Results A 64-year-old woman was referred to our hospital with recurrent diarrhea for longer than half a month. She underwent colonoscopy which revealed a polypoid lesion. The lesion was fully excised using EMR, and histopathological examination coupled with immunohistochemistry of the endoscopic biopsy confirmed a primary EMP of the rectum. She did not receive radiotherapy or chemotherapy after being diagnosed with EMP and experienced no recurrence or progression during the 6-month follow-up period.Conclusion Rectal EMP is an extremely rare clinical entity, Only 13 cases have been reported in the English-language literature as far as we know. Clinical suspicion is infrequent owing to its location and nonspecific manifestations. The diagnosis of EMP requires biopsy-proven monoclonal plasma cell infiltration of a single lesion, and the exclusion of multiple myeloma. Although EMP is a highly radiosensitive tumor, endoscopic therapy is increasingly becoming a good option for colorectal EMP when complete endoscopic resection of the tumor is possible. Generally, rectal EMP has an indolent course and the prognosis is favorable, but occasionally it may progress to multiple myeloma, or relapse. Therefore, the patients of EMP should be followed-up for a long time.
MicrobiotaCN: an on-line, standard, convenient and comprehensive microbiome data analysis platform based on self-built gut prokaryotic genome collection
Authors: Zheng Bo , Xu Junming , Qin Junjie , Fan Tingting , Li Lulu , Chen Yan , Jiang Yuyang 
Published: May 2022

Abstract
Background: The quality of the metagenomic data analysis depends on the quality of the reference database; however, the current database has some shortcomings. Different studies often use different reference databases for metagenomic analysis, resulting in inconsistent results, which can only be analyzed in isolation, and the results obtained from multiple projects are difficult to compare. Our work aimed to create a novel collection of human gut prokaryotic genomes, MBCN, as a reference database in a standardized metagenomic analysis platform named MicrobiotaCN that allows researchers to perform metagenomic analysis by the same standard pipeline efficiently.Results: About 2,477 human gut metagenomic samples were screened, and 16,785 MAGs (metagenomic assembled genomes) were assembled using a standardized pipeline. In addition, MAGs were combined with the representative genomes from the RefSeq and UHGG collections to cluster with 95% ANI clusters, and pan-genome for each cluster's genomes were constructed. MBCN collection contained 14,166 genomic species-level clusters. Kraken2 database was built with pan-genomes of MBCN and mOTUs database with the representative genomes of each cluster of MBCN. Comparing the Kraken database built by MBCN with other collections like UHGG on simulated reads and virtual bio-projects, the database built by MBCN was found to have a better assignment rate and more accurate profiling. In virtual bio-project and practical applications, MBCN had the potential to discover more biomarkers than other databases. We profiled 1,082 human gut metagenomic samples with MBCN Kraken2 database and organized the profiles and metadata on the platform, allowing users to get metagenomic profiles by the same standard pipeline. Simultaneously, common statistical and visualization tools for microbiome research were integrated into the on-line analysis platform.Conclusions: The reference database built based on MBCN was more comprehensive and accurate for profiling metagenomic reads, which integrates the use of the MicrobiotaCN online analysis platform will obtain a unified, one-stop metagenomic data analysis result. Thus, this could be a valuable resource for researchers to obtain profiles by a unified comprehensive reference database from different studies for meta-analysis. All data are available for free at http://www.microbiota.cn.
Clinical characteristics of active cytomegalovirus infection in patients with systemic lupus erythematosus of different sexes
Authors: Dai Nini , Zhou Rong , Li Xin , Zhao Jinxia , Li Qiuyu 
Published: May 2022

Abstract
Objective
To investigate the clinical characteristics of active cytomegalovirus (CMV) infection in patients with systemic lupus erythematosus (SLE) of different sexes.
Methods
SLE patients between September 2011 and March 2018 at Peking University Third Hospital were reviewed, and were followed up until the occurrence of active CMV infection, and their clinical data were collected. The clinical symptoms, laboratory tests, and follow-up data in patients of different sexes were analyzed statistically.
Results
Among 45 SLE patients with CMV active infection, 8 were male and 37 were female. The proportion of male patients with positive anticardiolipin antibody was higher than that of female patients (62.5% vs 8.1%, P = 0.002), and male patients had a higher proportion (50%) of abnormal liver function than female patients (50% vs 13.5%, P = 0.039). After 1:1 matching, active CMV infection occurred earlier in male patients (P = 0.041).
Conclusion
In our study, the proportion of positive anticardiolipin antibody and abnormal liver function were higher in male patients with SLE combined with active CMV infection. Active CMV infection occurred earlier in the course of SLE in male patients.
Utility of pathogenicity scores as diagnostic and prognostic markers for MPS disorders: In-silico analysis in MPS I
Authors: Kadali Srilatha , Bodiga Vijaya Lakshmi , Naushad Shaik Mohammad 
Published: May 2022

Abstract
Mucopolysaccharidoses (MPSs) is a major group of the lysosomal storage disorders (LSDs) with defective degradation of glycosaminoglycans (GAGs). Enzyme replacement therapy or bone marrow transplantation are the key therapeutic options available. Early diagnosis and appropriate intervention improve the therapeutic efficacy. We have used FATHMM, I-Mutant, PolyPhen-2, PATHER, PHD-SNP, SNP&GO, SIFT, PROVEAN, CUPSAT, SNAP2 for in silico analysis. These in silico tools and urinary GAG levels helped in monitoring the response to enzyme replacement therapy (ERT). Enzyme activity was inversely associated with SNAP2 (r= -0.36, p=0.04), Polyphen-2 (r= - 0.44, p=0.009) and Evolutionary preservation time (r= -0.396, p=0.02). This suggests that subjects having mutations with higher SNAP2 and Polyphen-2 score tend to have lower enzyme activity. ERT lead to 7 – 31% decrease in urinary GAG levels in seven MPS I patients. The determined pathogenicity scores are serving as prognostic markers indicating a response to therapy. Urinary GAG excretion is the primary end point to monitor the therapeutic efficacy.
What impact have COVID-19 induced changes in working practice had on greenhouse gas emissions? A rapid review
Authors: Spear Morwenna , Willcock Simon , Ormondroyd Graham , Dimitriou Athanasios , Roberts George , Loxton Ceri , Lewis Ruth , Cooper Alison , Law Rebecca-Jane , Edwards Adrian 
Published: May 2022

Abstract
The changes in working practice over the pandemic went through several distinct phases: the initial ‘lockdown’ period, a period of relaxation in some restrictions, and a longer-term period where working from home (WFH) was preferred if possible but many other aspects of life returned to near-normal. This Rapid Review was accompanied by high level life cycle assessment (LCA), to quantify the environmental profile of products, processes and behaviours based on energy use and commuting activity of office workers over a 7 day period. We aimed to describe trends in environmental effects, specifically regarding greenhouse gas emissions relating to energy usage and commuting behaviour, during the pandemic. For the rapid literature review, 32 studies were identified. § Rapid Review findings corroborated the life cycle assessment findings that energy for space heating (both at home and in the office) and transport dominated the greenhouse gas emissions profile.§ Domestic energy consumption remained elevated after easing restrictions with a displacement of energy normally consumed in business premises.§ Overall, there was a net reduction in consumption and greenhouse gas emissions with greater working from home.§ There has been a shift away from public transport with a negative effect on greenhouse gas emissions.§ Travel distance and mode of transport are significant factors in determining the magnitude of benefits seen when working from home.§ Air quality is reported to have been affected by the lockdown period, but no studies have directly evaluated the working from home component of this.For the Life cycle assessment, analysis was based on 10 workers at home or in an office in typical UK housing and a typical office with two transport options for commuting (car and train), over 7 days. A clear benefit was seen in reducing greenhouse gas emissions for working from home compared to office work with travel by car, and a smaller benefit for working from home compared to office work by train. The working from home scenario had significantly lower impact than both the car and train commute scenarios on marine ecotoxicity and freshwater ecotoxicity indicators.
Numerical Solutions of (3+1)-Dimensional mKdV and (3+1)-Dimensional mBBM Equations and their Applications in Water Waves
Authors: GUPTA ARUN KUMAR , Hazarika Jyotishman 
Published: May 2022

Abstract
In this manuscript, the Optimal Homotopy Asymptotic Method (OHAM) has been implimented to construct the approximate solutions of (3 + 1)-dimensional mKdV equation and (3 + 1)-dimensional mBBM equation. These (3 + 1)-dimensional differential equations are deemed more convincing from physical phenomena standpoint as opposed to the corresponding (1 + 1) and (2 + 1)-dimensional equations. The solutions obtained by OHAM are illustrated graphically to its exact solution counterpart. This paper presents new possibilities to solve higher dimensional NPDEs numerically, which has not been attempted previously in the literature as per the best possible information of the authors. The technique examined here is plausible, efficacious, and can be employed to compute new numerical solutions of NPDEs arising in mathematical physics.
Simultaneous bilateral laparoscopic cortical-sparing adrenalectomy for bilateral pheochromocytomas in multiple endocrine neoplasia type 2
Authors: Qi Xiao-Ping , Lian Bi-Jun , Fang Xu-Dong , Dong Fang , Li Feng , Jin Hang-Yang , Zhang Ke , Wang Kang-Er , Zhang Yi 
Published: May 2022

Abstract
Purpose: To assess the feasibility of simultaneous bilateral laparoscopic or open cortical-sparing adrenalectomy (LCSA or OCSA) for bilateral pheochromocytomas (bPHEO) in multiple endocrine neoplasia type 2 (MEN2).Methods: A total of 31 patients (54.8% women) were diagnosed with MEN2 related bPHEO, in who 29 underwent varying specific adrenal surgery. We systematically analyzed and evaluated their clinical profiles, mutation types, tumor histopathologic features, and follow-up records. Results: All 31 patients with bPHEO associated with RET-C634 mutations, as MEN2A (90.3%) and RET-M918T, as MEN2B (9.7%), respectively, were at a median age at initial presentation of 38 years (range, 23–78). Of these, 27 (87.1%) presented with synchronous and other 4 (12.9%) with metachronous. Among 29 underwent initial CSA, and in 23 (79.3%), of whom 18 had SB-LCSA and 5 had SB-OCSA duration of the same anesthesia (synchronous surgery); whereas metachronous CSA was in 6 (20.7%). There were less bleeding volume, and shorter hospitalizations between in SB-LCSA compared with those in SB-OCSA, as well as synchronous surgery versus metachronous (hybrid) surgery (all P < 0.05). An initial bilateral postoperative corticosteroid replacement was necessary in 14 patients (45.2%). During a median follow-up period of 7 years (range, 1.8–23), 3 of these patients (10.3%) showed a persistent/recurrent disease and needed reoperation. Whereas the remaining 2 patients respectively presenting MEN2A died of MTC metastasis or MEN2B declined surgery in who chose waiting watchful.Conclusions: SB-LCSA for treatment of these synchronous bPHEO is safe and feasible, should be recommended as a prioritized surgical approach of choice.
Neurological Complications in Systemic Inflammatory Diseases
Authors: Casanova Ignacio , Prada Alejandro , De Silanes Carlos López , Gonzaga Luis , Barrio Laura , Eimil Miriam , Oyanguren Beatriz , Alcántara Pilar , Saíz Miguel Ángel , Díaz Blanca , González Miriam , González Marta 
Published: May 2022

Abstract:
Systemic inflammatory diseases could produce neurologic complications, and they are
frequently incorporated in the differential diagnosis of neurological symptoms. There are wellestablished
criteria to meet the diagnosis of neurologic manifestations of these systemic diseases.

Methods:
However, the range of clinical presentations varies in each condition, and the prevalence
of these complications differs between studies. Hence, in many cases, an etiological relationship is
not clearly defined.

Results and Conclusion:
For these reasons, it is challenging to make an accurate diagnosis. We analyzed
the spectrum of neurological manifestations in a cohort of patients with systemic lupus erythematosus,
rheumatoid arthritis, Behçet disease and sarcoidosis in order to improve our current
knowledge of these complications.
Cerebral Vasoreactivity in a Fabry Disease Patient
Authors: Siniscalchi Antonio , La Russa Antonella , Lochner Piergiorgio , Petrone Alfredo , Russo Bina 
Published: May 2022

Background:
Fabry disease (FD) is a rare X-linked multisystem lysosomal storage disease
caused by partial or total deficiency of a-galactosidase A (GLA). A progressive involvement of the
kidneys, heart, and brain arteries has been reported. Using the transcranial color-coded duplex Doppler
(TCCD), we report the case of a Fabry disease (FD) patient with a reduction in the cerebrovascular
reactivity of the basilar artery (BA).

Methods:
A 46-year-old male asymptomatic FD patient underwent ultrasound intracranial investigation.

Case Report:
We report the case of a 46-year-old man affected by asymptomatic FD, who
presented to our observation for episodes of vertigo. Cerebral MRI and AngioMRI were found to be
normal. There was no postural hypotension observed. Otolaryngology and cardiac examinations revealed
no pathological condition. A TCCD showed normal cerebral vascular reactivity (CVR) in the
bilateral middle cerebral arteries (MCA), breath-holding index (BHI) was 1.3 in the right MCA (RMCA)
and 1.4 in left MCA (LMCA), and BHI in the basilar artery (BA) was reduced (BHI: 0,56).

Conclusion:
This case suggests an earlier alteration of CVR in the posterior cerebral circulation than
in the anterior cerebral circulation in an asymptomatic FD patient. This alteration of CVR may be an
earlier marker of FD diagnosis.