bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dynamic circadian fluctuations of glycemia in patients with type 2 diabetes mellitus
Authors: Vásquez-Muñoz Manuel , Arce-Álvarez Alexis , Álvarez Cristian , Ramírez-Campillo Rodrigo , Crespo Fernando A. , Arias Dayana , Salazar-Ardiles Camila , Izquierdo Mikel , Andrade David C. 
Published: December 2022

Abstract
Background
Diabetes mellitus (DM) has glucose variability that is of such relevance that the appearance of vascular complications in patients with DM has been attributed to hyperglycemic and dysglycemic events. It is known that T1D patients mainly have glycemic variability with a specific oscillatory pattern with specific circadian characteristics for each patient. However, it has not yet been determined whether an oscillation pattern represents the variability of glycemic in T2D. This is why our objective is to determine the characteristics of glycemic oscillations in T2D and generate a robust predictive model.

Results
Showed that glycosylated hemoglobin, glycemia, and body mass index were all higher in patients with T2D than in controls (all p < 0.05). In addition, time in hyperglycemia and euglycemia was markedly higher and lower in the T2D group (p < 0.05), without significant differences for time in hypoglycemia. Standard deviation, coefficient of variation, and total power of glycemia were significantly higher in the T2D group than Control group (all p < 0.05). The oscillatory patterns were significantly different between groups (p = 0.032): the control group was mainly distributed at 2–3 and 6 days, whereas the T2D group showed a more homogeneous distribution across 2–3-to-6 days.

Conclusions
The predictive model of glycemia showed that it is possible to accurately predict hyper- and hypoglycemia events. Thus, T2D patients exhibit specific oscillatory patterns of glycemic control, which are possible to predict. These findings may help to improve the treatment of DM by considering the individual oscillatory patterns of patients.
Efficacy of direct oral anticoagulant for renal infarction due to pulmonary vein stump thrombosis after left pneumonectomy
Authors: Iijima Yoshihito , Iwai Shun , Motono Nozomu , Uramoto Hidetaka 
Published: December 2022

AbstractBackgroundThrombosis of the pulmonary vein stump is a common complication after a left upper lobectomy and can be a source of embolism in various organs, such as the kidneys. A renal infarction, on the other hand, is a rare and often lethal condition that is usually diagnosed postmortem. Here, we present a case of renal infarction associated with pulmonary vein stump thrombosis after a left pneumonectomy, which was treated successfully with edoxaban.Case presentationA 73-year-old man was diagnosed with squamous cell lung cancer (cT1miN0M0 stage IA1). Due to pneumoconiosis, extensive lymph node infiltration into the pulmonary artery was noted and necessitated an open thoracotomy. Ultimately, a left pneumonectomy was performed. Atrial fibrillation occurred on postoperative day 3, and the patient complained of left-sided abdominal pain. Contrast-enhanced computed tomography revealed a left upper pulmonary vein thrombosis and a left renal infarction. Anticoagulant therapy was immediately initiated with heparin and warfarin. On postoperative day 13, warfarin was replaced with the direct oral anticoagulant edoxaban since the patient’s compliance and drug response to warfarin were poor. On postoperative day 19, contrast-enhanced computed tomography revealed a reduction in pulmonary vein stump thrombosis and improvement in renal infarction. Subsequently, the patient was discharged. Three months post-surgery, no infarct lesions or reduced renal function was observed on imaging.ConclusionsThe direct oral anticoagulant edoxaban could be effective in preventing recurrence or exacerbation of pulmonary vein thrombosis associated with renal infarction without bleeding complications.
Immune checkpoint inhibitors and the risk of major atherosclerotic cardiovascular events in patients with high-risk or advanced melanoma: a retrospective cohort study
Authors: Wang Charlie , Zoungas Sophia , Yan Mabel , Wolfe Rory , Haydon Andrew , Shackleton Mark , Voskoboynik Mark , Moore Maggie , Andrews Miles C. , Nicholls Stephen J. , Mar Victoria 
Published: December 2022

Abstract
Background
Immune checkpoint inhibitors (ICI) are associated with immune-mediated adverse effects, potentially involving any organ. ICI has also been associated with an increased risk of cardiovascular disease in cancer populations.

Objective
To characterize the incidence and risk of major atherosclerotic cardiovascular events associated with ICI use in a high-risk and advanced melanoma population.

Methods
We conducted a retrospective cohort study of patients with high-risk or advanced melanoma (AJCC stage II, III or IV) presenting to an academic tertiary hospital between 2015–2020. The main outcome was major atherosclerotic cardiovascular events (MACE) including acute myocardial infarction, ischemic stroke, acute limb ischemia and coronary revascularization.

Results
The study cohort consisted of 646 patients, including 289 who had been treated with ICI. The incidence of MACE was higher in the ICI treated group (3.6 vs. 0.9 events per 100-person years). After adjusting for age, sex, smoking history and prior BRAF and/or MEK inhibitor use, ICI treatment was associated with an increased risk of MACE (HRadj 2.8, 95% CI 1.1–6.9, p = 0.03). Elevated risk was especially pronounced in patients with a past history of MACE (HR 14.4, 95% CI 1.9–112.3, p = 0.01).

Conclusion
Patients with high-risk or advanced melanoma are at an increased risk of atherosclerotic cardiovascular events following ICI treatment, particularly those with a history of cardiovascular disease.
Policy stakeholder perspectives on barriers and facilitators to launching a community-wide mass drug administration program for soil-transmitted helminths
Authors: Roll Amy , Saxena Malvika , Orlan Elizabeth , Titus Angelin , Juvekar Sanjay Kamlakar , Gwayi-Chore Marie-Claire , Avokpaho Euripide , Chabi Félicien , Togbevi Comlanvi Innocent , Belou Elijan Abiguel , Nindi Providence , Walson Judd L. , Ajjampur Sitara S. R. , Ibikounlé Moudachirou , Kalua Khumbo , Aruldas Kumudha , Means Arianna Rubin 
Published: December 2022

Abstract
Background
Recent evidence suggests that soil-transmitted helminth (STH) transmission interruption may be feasible through community-wide mass drug administration (cMDA) that deworms community members of all ages. A change from school-based deworming to cMDA will require reconfiguring of STH programs in endemic countries. We conducted formative qualitative research in Benin, India, and Malawi to identify barriers and facilitators to successfully launching a cMDA program from the policy-stakeholder perspective.

Methods
We conducted 40 key informant interviews with policy stakeholders identified as critical change agents at national, state/district, and sub-district levels. Participants included World Health Organization country office staff, implementing partners, and national and sub-national government officials. We used the Consolidated Framework for Implementation Research to guide data collection, coding, and analysis. Heat maps were used to organize coded data and differentiate perceived facilitators and barriers to launching cMDA by stakeholder.

Results
Key facilitators to launching a cMDA program included availability of high-quality, tailored sensitization materials, and human and material resources that could be leveraged from previous MDA campaigns. Key barriers included the potential to overburden existing health workers, uncertainty of external funding to sustain a cMDA program, and concerns about weak intragovernmental coordination to implement cMDA. Cross-cutting themes included the need for rigorous trial evidence on STH transmission interruption to gain confidence in cMDA, and implementation evidence to effectively operationalize cMDA. Importantly, if policy stakeholders anticipate a cMDA program cannot be sustained due to cost and human resource barriers in the long term they may be less likely to support the launch of a program in the short term.

Conclusions
Overall, policy stakeholders were optimistic about implementing cMDA primarily because they believe that the tools necessary to successfully implement cMDA are already available. Policy stakeholders in this study were cautiously optimistic about launching cMDA to achieve STH transmission interruption and believe that it is feasible to implement. However, launching cMDA as an alternative policy to school-based deworming will require addressing key resource and evidence barriers.
Trial registration This study was registered in the U.S. National Library of Medicine Clinical Trials registry (NCT03014167).
Deep 3D mesh watermarking with self-adaptive robustness
Authors: Wang Feng , Zhou Hang , Fang Han , Zhang Weiming , Yu Nenghai 
Published: December 2022

AbstractRobust 3D mesh watermarking is a traditional research topic in computer graphics, which provides an efficient solution to the copyright protection for 3D meshes. Traditionally, researchers need manually design watermarking algorithms to achieve sufficient robustness for the actual application scenarios. In this paper, we propose the first deep learning-based 3D mesh watermarking network, which can provide a more general framework for this problem. In detail, we propose an end-to-end network, consisting of a watermark embedding sub-network, a watermark extracting sub-network and attack layers. We employ the topology-agnostic graph convolutional network (GCN) as the basic convolution operation, therefore our network is not limited by registered meshes (which share a fixed topology). For the specific application scenario, we can integrate the corresponding attack layers to guarantee adaptive robustness against possible attacks. To ensure the visual quality of watermarked 3D meshes, we design the curvature consistency loss function to constrain the local geometry smoothness of watermarked meshes. Experimental results show that the proposed method can achieve more universal robustness while guaranteeing comparable visual quality.
Nutritional composition of tauco as Indonesian fermented soybean paste
Authors: Herlina Vika Tresnadiana , Lioe Hanifah Nuryani , Kusumaningrum Harsi Dewantari , Adawiyah Dede Robiatul 
Published: December 2022

AbstractTauco is a fermented soybean paste like miso but typical from Indonesia, commonly used as umami seasoning. This study objective was to evaluate the nutritional composition of diverse tauco products found in Indonesia and to determine a potential tauco product characterized by certain amino acids related to umami peptides (Asp, Glu, Gly, Ser, Thr, Val). Proximate composition, NaCl salt, total sugars, total acids, and total amino acid profiles of 24 tauco products, collected from 24 producers in 7 provinces in Indonesia, were analyzed. The proximate composition mapped tauco into solid (containing 29.2–35.3% moisture on wet weight basis or ww), semisolid (42.2–54.5% ww moisture), and liquid (56.2–68.1% ww moisture). Solid tauco composed of 54.7–65.2% carbohydrates, 10.0–22.8% ashes, 7.13–16.9% NaCl salt, 9.72–11.9% crude proteins, 11.9–27.0% total sugars, 6.98–23.4% crude fats, 1.24–2.18% total acids, and 11.4–17.5% total amino acids on dry weight basis (dw). In contrast, liquid tauco consisted of 8.47–56.5% dw carbohydrates, 17.1–73.8% dw ashes, 10.7–68.4% dw NaCl, 20.4–30.9% dw crude proteins, 4.45–29.9.5% dw total sugars, 1.30–18.9% dw crude fats, 1.65–5.36% dw total acids, and 14.1–24.6% dw total amino acids. All tauco had a slight acidic pH, ranged from 4.38 to 5.91. Glu and Asp were the dominant amino acids of tauco, comprising 25–40% of total amino acids. Mapping of total amino acid profile mentioned a tauco product, characterized by the highest concentration of amino acids related to umami peptides. This finding leads to the exploration of umami peptides to reveal the science behind its traditional use as umami seasoning.
Wrapping collagen-based nanoparticle with macrophage membrane for treating multidrug-resistant bacterial infection
Authors: Li Yuanyuan , Xiong Jianming , Hu Yi , Miao Wenjun , Huang He 
Published: December 2022

AbstractNowadays, multidrug-resistant (MDR) bacterial infectious diseases has become a thorny issue in the healthcare field. Owning to its intrinsic merits, photodynamic therapy (PDT) shows tremendous strengths in fighting against MDR bacterial infections. However, most photodynamic nanoplatforms exhibit unsatisfactory targeting efficiency towards bacteria and infection site, which may compromise the bactericidal effect of PDT. Herein, we firstly reported a bacteria-targeted collagen-based nanoparticle, named Ce6/Col/MM, for treating methicillin-resistant Staphylococcus aureus (MRSA)-infected wound. Ce6/Col/MM was fabricated by wrapping chlorin e6 (Ce6)-loaded collagen-based nanoparticles with macrophage membrane (MM), showing excellent photodynamic activity and good biocompatibility. In vitro studies demonstrated that Ce6/Col/MM could target to bacteria and then exhibit prominent antibacterial capacity against planktonic MRSA under light irradiation. Furthermore, the treatment of MRSA-infected wound in mice with Ce6/Col/MM plus light illumination resulted in potent bacterial inactivation and accelerated wound healing, accompanied by favorable histological compatibility. Collectively, Ce6/Col/MM with superior targeting ability towards bacteria, effective photodynamic antibacterial potency and minimal safety concerns, might be a powerful bactericidal nanoagent for treating infections caused by MDR bacteria.
Graphical Abstract
Integrated framework for existing building alternatives by the building information modeling
Authors: Mahmoud Heba Mustafa , Fayad Aly Abdel , Nassar Ayman H. 
Published: December 2022

AbstractUrban expansion is undergoing rapid growth, prompting several nations to create financial and administrative capitals outside congested urban areas, leaving the existing buildings unoccupied. To investigate the possibilities of changing the real estate’s usage, the owners of these existing buildings turned to feasibility study experts for assistance in making the optimum alternatives. An integrated framework between value engineering and building information modeling, especially appropriate for existing buildings, is required to aid decision-makers in selecting the best options for current building utilization. Previous studies only investigated the value engineering alternatives during the design phase, when they decided to reduce project costs using construction materials alternatives. Still, they overlooked existing building alternatives in terms of changing the kind of usage of such buildings. So, they need an integrated model between value engineering and building information modeling, especially applicable to an existing structure, to determine the optimum usage type for the existing building. Value engineering and building information modeling must be connected to profit from both outputs simultaneously. And used the multi-criteria decision-analysis method. Today’s analytic hierarchy process is the most widely used. This paper provides an integrated framework between value engineering and building information modeling that can be applied to existing buildings to assist in determining the best alternative in terms of the type of usage for such existing structures by conducting BIM methodologies such as a feasibility study which includes present value, cash flow and the bank interest rate, and BIM software such as Revit and Primavera. The multi-criteria decision analysis method was used to focus on what is important, logical, consistent, and easy to use. MCDA which considered a process for evaluating options with conflicting criteria and choosing the best solution, similar to a cost–benefit analysis, but evaluates numerous criteria rather than just cost. The findings revealed that this integrated framework, which includes feasibility studies and comparison tables, may be implemented in the future while taking into account time and location constraints.
Mental health services in Ukraine during the early phases of the 2022 Russian invasion
Authors: Goto Ryunosuke , Pinchuk Irina , Kolodezhny Oleksiy , Pimenova Nataliia , Skokauskas Norbert 
Published: December 2022

BackgroundIn February 2022, Russia began its invasion of Ukraine. War increases the demand for mental healthcare among affected populations, but with devastating losses across the nation, it is unclear if Ukrainian mental health services are able to meet the needs of the people.AimsWe aimed to evaluate the state of Ukrainian in-patient mental health services, which remains the backbone of the nation's psychiatric services, early in the 2022 Russian invasion.MethodWe conducted a nationwide cross-sectional study on Ukrainian in-patient mental health facilities during the 2022 Russian invasion. Using an online questionnaire, we obtained responses from the heads of 32 in-patient mental health facilities across Ukraine, representing 52.5% of all in-patient mental health facilities in the nation. We gathered information on hospital admissions, staff, humanitarian aid received and the additional needs of each facility.ResultsHospital admissions were reduced by 23.5% during the war (April 2022) compared with before the war (January 2022). Across facilities, 9.6% of hospital admissions in April 2022 were related to war trauma, with facilities reporting percentages as high as 30.0%. Facilities reported reductions in staff, with 9.1% of total medical workers displaced and 0.5% injured across facilities. One facility reported that 45.6% of their total medical workers were injured. Although facilities across Ukraine have received humanitarian aid (such as medical supplies, food, volunteers), they reported additionally needing equipment as well as more staff.ConclusionsThe mental health service structure in Ukraine has been severely damaged during the 2022 invasion, with staff shortages despite a significant number of hospital admissions related to war trauma.
Axatilimab for Chronic Graft-Versus-Host Disease After Failure of at Least Two Prior Systemic Therapies: Results of a Phase I/II Study
Authors: Kitko Carrie L. , Arora Mukta , DeFilipp Zachariah , Zaid Mohammad Abu , Di Stasi Antonio , Radojcic Vedran , Betts Courtney B. , Coussens Lisa M. , Meyers Michael L. , Qamoos Hope , Ordentlich Peter , Kumar Vinit , Quaranto Christine , Schmitt Aaron , Gu Yu , Blazar Bruce R. , Wang Trent P. , Salhotra Amandeep , Pusic Iskra , Jagasia Madan , Lee Stephanie J. 
Published: December 2022

PURPOSE Chronic graft-versus-host disease (cGVHD) remains the major cause of late morbidity after allogeneic hematopoietic cell transplantation. Colony-stimulating factor 1 receptor (CSF-1R)–dependent macrophages promote cGVHD fibrosis, and their elimination in preclinical studies ameliorated cGVHD. Axatilimab is a humanized monoclonal antibody that inhibits CSF-1R signaling and restrains macrophage development. PATIENTS AND METHODS This phase I (phI)/phase II (phII) open-label study (ClinicalTrials.gov identifier: NCT03604692 ) evaluated safety, tolerability, and efficacy of axatilimab in patients age ≥ 6 years with active cGVHD after ≥ 2 prior systemic therapy lines. Primary objectives in phI were to identify the optimal biologic and recommended phII dose and in phII to evaluate the overall (complete and partial) response rate (ORR) at the start of treatment cycle 7. RESULTS Forty enrolled patients (17 phI; 23 phII) received at least one axatilimab dose. In phI, a dose of 3 mg/kg given once every 4 weeks met the optimal biologic dose definition. Two dose-limiting toxicities occurred at the 3 mg/kg dose given once every 2 weeks. At least one treatment-related adverse event (TRAE) was observed in 30 patients with grade ≥ 3 TRAEs in eight patients, the majority known on-target effects of CSF-1R inhibition. No cytomegalovirus reactivations occurred. With the 50% ORR at cycle 7 day 1, the phII cohort met the primary efficacy end point. Furthermore, the ORR in the first six cycles, an end point supporting regulatory approvals, was 82%. Responses were seen in all affected organs regardless of prior therapy. Fifty-eight percent of patients reported significant improvement in cGVHD-related symptoms using the Lee Symptom Scale. On-target activity of axatilimab was suggested by the decrease in skin CSF-1R–expressing macrophages. CONCLUSION Targeting profibrotic macrophages with axatilimab is a therapeutically promising novel strategy with a favorable safety profile for refractory cGVHD.
A kidney resident macrophage subset is a candidate biomarker for renal cystic disease in preclinical models
Authors: Li Zhang , Zimmerman Kurt A. , Cherakara Sreelakshmi , Chumley Phillip H. , Collawn James F. , Wang Jun , Haycraft Courtney J. , Song Cheng J. , Chacana Teresa , Andersen Reagan S. , Croyle Mandy J. , Aloria Ernald J. , Hombal Raksha P. , Thomas Isis N. , Chweih Hanan , Simanyi Kristin L. , George James F. , Parant John M. , Mrug Michal , Yoder Bradley K. 
Published: December 2022

ABSTRACT
Although renal macrophages have been shown to contribute to cyst development in polycystic kidney disease (PKD) animal models, it remains unclear whether there is a specific macrophage subpopulation involved. Here, we analyzed changes in macrophage populations during renal maturation in association with cystogenesis rates in conditional Pkd2 mutant mice. We observed that CD206+ resident macrophages were minimal in a normal adult kidney but accumulated in cystic areas in adult-induced Pkd2 mutants. Using Cx3cr1 null mice, we reduced macrophage number, including CD206+ macrophages, and showed that this significantly reduced cyst severity in adult-induced Pkd2 mutant kidneys. We also found that the number of CD206+ resident macrophage-like cells increased in kidneys and in the urine from autosomal-dominant PKD (ADPKD) patients relative to the rate of renal functional decline. These data indicate a direct correlation between CD206+ resident macrophages and cyst formation, and reveal that the CD206+ resident macrophages in urine could serve as a biomarker for renal cystic disease activity in preclinical models and ADPKD patients.
This article has an associated First Person interview with the first author of the paper.
THE INFLUENCE OF INTERNET ADDICTION ON ANXIETY INDICATORS IN MEDICAL UNIVERSITY STUDENTS
Authors: Derevyannich Evgeny V. , Balashova Natalia A. , Yaskevich Roman A. , Moskalenko Olga L. 
Published: December 2022

The purpose of the study. To study the influence of Internet addiction on anxiety indicators in medical university students.
Materials and methods. The study included 145 students of both sexes studying at a medical university. To assess the level of Internet addiction, the S. Chen scale – CIAS (Chen Internet addiction Scale) used in the adaptation of Malygin V. L. and Feklisov K. A. To identify and assess the severity of anxiety disorders, the hospital scale of anxiety and depression – HADS used.
Results. It found that 8.2% of the surveyed medical students revealed a pronounced and stable pattern of Internet-dependent behavior on the CIAS scale. Symptoms of anxiety of varying severity were twice as common among female students. When studying the influence of Internet-dependent behavior on anxiety indicators, it was found that among students with Internet addiction, people with symptoms of anxiety of varying severity were more common, compared with students who are prone to Internet addiction and do not have addiction.
Conclusion. The results of the study demonstrated the presence of a high level of anxiety disorders in medical university students with Internet addiction.