bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cu‐Zn SOD suppresses epilepsy in pilocarpine‐treated rats and alters SCN2A/Nrf2/HO‐1 expression
Authors: Wen Fang , Tan Zhi‐Gang , Xiang Jun 
Published: July 2022

AbstractObjective. Copper‐zinc superoxide dismutase (Cu‐Zn SOD) is downregulated in epilepsy, however, the role of Cu‐Zn SOD in epilepsy remains unclear.Methods. Based on the pilocarpine hydrochloride‐induced rat model of epilepsy, cortical‐striatum brain slices of rats were examined based on field excitatory post‐synaptic potentials. Pathological changes were observed by transmission electron microscope. Also using SH‐SY5Y cells, flow cytometry and TUNEL staining were applied to investigate cell apoptosis, and ELISA was applied to detect SOD activity. In addition, qRT‐PCR and western blot were performed to detect SCN2A/Nrf2/HO‐1 gene and protein expression levels, respectively.Results. Cu‐Zn SOD over‐expression suppressed epilepsy in vivo. In addition, Cu‐Zn SOD knockdown notably decreased SOD activity and induced apoptosis in SH‐SY5Y cells. Moreover, Cu‐Zn SOD silencing decreased the levels of SCN2A, Nrf2 and HO‐1. Lastly, Cu‐Zn SOD was shown to modulate the NaV1.2/Nrf2/HO‐1 axis in rats.Significance. In this model, Cu‐Zn SOD attenuated epilepsy and was shown to alter the expression level of proteins of the NaV1.2 /Nrf2/HO‐1 signalling pathway, indicating that Cu‐Zn SOD might be a target for the treatment of epilepsy.
Rare case of unforeseen tragic event of severe anaphylactic reaction to lidocaine in a paediatric patient in rural low resource setup
Authors: Harangulkar Vishal R. , Ingale Suryakant Y. , Murde Snehal G. 
Published: July 2022

Anaphylactic reaction to lidocaine is a very rare and life-threatening event. Lidocaine (xylocaine) is one of the most common anaesthetic drugs used as local anaesthetics for minor dental and other minor surgical procedure. Although minor allergic reactions after administration of lidocaine are common and easily resolved after just antihistaminic with or without steroid administration. However severe anaphylaxis leading to death is very rare; so much that the physicians might be unaware of its occurrence and its emergency management. From 1957 to 2012, there were seven reports of single case and one report of 8 cases with sufficient information for review. In paediatric patients, very few have history of allergies and due to unawareness of their allergic condition they may land in tragic event of anaphylaxis which if not managed on time can lead to death. We hereby presented such a rare case of a 14 years old female posted for a minor surgical procedure, who had anaphylactic shock due to lidocaine, followed by sudden cardiorespiratory arrest leading to death despite of all the prompt management.
Artificial intelligence - A boon for dentistry
Authors: Mitra Radhika , Tarnach Gitanjali 
Published: July 2022

Today artificial intelligence (AI) is becoming increasingly important in the healthcare industry. It can be useful in many areas where humans can be aided by new technologies. The concept of "artificial intelligence" (AI) refers to machines being capable of performing human tasks. Machine learning (ML) is an AI subdomain that "learns" intrinsic statistical patterns in data to ultimately make predictions on unseen data. Deep learning is a machine learning technique that employs multi-layer mathematical operations to learn and infer on complex data such as imagery. With the substantial growth in documented information and patient data, intelligent data computation software has become a requirement. Artificial intelligence has a wide range of applications in medicine and dentistry, from data processing and information retrieval to the use of neural networks for diagnosis and the incorporation of augmented reality and virtual reality into dental education. Artificial intelligence (AI) is being studied in dentistry for a variety of purposes, including the identification of normal and anomalous structures, disease diagnosis, and treatment outcome prediction. This review looks at some current and future applications of AI in dentistry. We are ushering in a modern age, and AI is undeniably the future of dental practise management.
Comparative Analysis of Fresh Food E-Commerce Business Models under " New Retail " —— Taking Pupu Supermarket and Hema Fresh as Examples
Authors: Liu  Junya 
Published: July 2022

<p>With the continuous development of network marketing, the combination of online and offline mode emerges as the times require. On this basis, compare and analyze the business models of Pupu Supermarket and Hema Xiansheng, using the theoretical framework of 3W2H , analyze and compare around five basic elements, describe the status quo of business models under different e-commerce models, and analyze their core essence. Extract and summarize its successful model, and make suggestions for fresh food e-commerce, and continuously improve the business model of fresh food e-commerce.</p>
Innovation and Entrepreneurship Education in Higher Vocational Colleges Based on School Enterprise Cooperation Mode
Authors: Zhao Chunyu , Noichun Dr. 
Published: July 2022

School enterprise cooperation is not only an important way for the development of higher vocational colleges, but also
an effective method for vocational schools to cultivate high-quality technical and skilled talents for the society. In order to better
realize the sustainable development of higher vocational colleges and promote the quality and efficiency of vocational education,
it is necessary to carry out innovation and entrepreneurship education based on the school enterprise cooperation mode. On the one
hand, under the mode of school enterprise cooperation, strengthen the construction of “double qualified” teachers and cultivate
innovative high-quality teachers. On the other hand, under the school enterprise cooperation mode, realize the scientific setting and
adjustment of disciplines and majors, and deepen the teaching method reform of innovation and entrepreneurship education. Under
the mode of school enterprise cooperation, reform the innovation and entrepreneurship education, improve the teaching level, close
the relationship between schools and enterprises, transport innovation and entrepreneurship talents for the society, and promote the
high-quality development of Vocational Education in higher vocational colleges.
The Behavior of Tik Tok Users in Palopo City and Responses to the Qur'an
Authors: R. Serli , Mutakabbir Abdul , P. Ependi 
Published: July 2022

Tik Tok is a new platform that young people love, and kids are no exception. This platform encompasses all levels of society, including adults and even the elderly. TikTok has both positive and negative sides like any other medium. Therefore, this study aims to determine the understanding of the community, especially the people of Palopo, about the benefits of Tik Tok and how to use it. This research is a field study with the people of Palopo city as informants for interviews and documentation. As a result, Tik Tok is used more than a means of entertainment, which sometimes leads to verbal and physical disrespectful behaviour. Some opinions say that Tik Tok is an online media short video that shows recordings of dancing and showing TikTok-er's genitals. The people of Palopo city consider TikTokers more for entertainment filled with dancing. Therefore, it is necessary to limit access to various media, including TikTok, so as not to be carried away by immoral behaviour. Thus, the Qur'an is the key and a solution to protect yourself by not showing your aurat. It means that Tik Tok may dive without showing aurat and indulgence in lust. For further researchers, it is necessary to research the effects caused by the application and the solution before and after being exposed to the syndrome.
TAPHOGRAPH: A SPREADSHEET METHOD TO GRAPHICALLY CHARACTERIZE THE TAPHONOMY OF SKELETAL PARTICLES
Authors: CARON VINCENT , JOANNY FRANÇOIS-XAVIER , BAILLEUL JULIEN , PEROT MAXIME , CHANIER FRANK , MAHIEUX GEOFFROY 
Published: July 2022

ABSTRACTTaphonomic analysis is a useful tool to assess the intensity of alteration of skeletal remains and to help characterize depositional conditions as well as completeness and resolution of fossil assemblages. We herein introduce TAPHOGRAPH, an Excel spreadsheet script (a R code is also available), for the production of taphonomic diagrams to characterize the taphonomy of skeletal remains. The graphical representation depicts four taphonomic factors (fragmentation, abrasion, bioerosion, and encrustation) as a cumulative curve that allows visualization and comparison of the degree and variability of taphonomic alteration for different hard part types from one or more samples in a single diagram. The TAPHOGRAPH methodology is highly flexible, and can be used to assess the relative influence of mechanical versus biological (versus chemical) taphonomic alteration. The TAPHOGRAPH approach can guide inferences about hydraulic regimes, residence time at the seafloor, and intensity of different taphonomic processes.
Linkage to HIV care following HIV self-testing among men: systematic review of quantitative and qualitative studies from six countries in sub-Saharan Africa
Authors: Hlongwa Mbuzeleni , Hlongwana Khumbulani , Makhunga Sizwe , Choko Augustine , Dzinamarira Tafadzwa , Conserve Donaldson , Tsai Alexander 
Published: July 2022

Abstract
Gender disparities are pervasive throughout the HIV care continuum in sub-Saharan Africa, with men testing, receiving treatment, and achieving viral suppression at lower rates, and experiencing mortality at higher rates, compared with women. HIV self-testing (HIVST) has been shown to be highly acceptable among men in sub-Saharan Africa. However, evidence on linkage to HIV care following a reactive HIVST result is limited. In this systematic review, we aimed to synthesize the quantitative and qualitative literature on linkage to HIV care after receiving a reactive HIVST result among men in sub-Saharan Africa. We systematically searched 14 bibliometric databases. The Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) flow diagram was used to document the screening results. The Mixed Methods Appraisal Tool (MMAT) was used to assess the methodological quality of the included studies. Of 22 446 references screened, 15 articles were eligible for inclusion in this review. Linkage to HIV care following a reactive HIVST result was subject to several barriers: financial constraints due to travelling costs, potential long waiting hours at the clinics, stigma, discrimination, and privacy concerns. Rates of men seeking confirmatory testing and linking to HIV care following a reactive HIVST result were inconsistent. Combining financial incentives with HIVST was found to increase the likelihood of linkage to HIV care following a reactive HIVST result. The variable rates of linkage to HIV care following a reactive HIVST result suggest the need for further research and development of strategies to increase linkage to HIV care.
COVID-19 Prevention Measures Among Refugees: Perspectives of Healthcare Providers Working in Refugee Camps in Rwanda
Authors: Nzeyimana Zephanie , Rwibasira Gallican , Manishimwe Fraterne , Winterhalter Frieda S. , Ndoli Ella Larissa , Ngomi Nicholas Njau , Dzinamarira Tafadzwa 
Published: July 2022

Abstract
Background
The coronavirus disease 2019 (COVID-19) that emerged from Wuhan, China in 2019 rapidly spread throughout the globe in less than 6 months. In June 2020, Rwanda was a home of approximately 149,602 refugees. About 92% of the refugees were living in camps including Kiziba, Gihembe, Nyabiheke, Kigeme, Mugombwa, and Mahama. While entire world was in some level of lockdown, people living in refugee camps and other similar settings were more vulnerable to the pandemic than their counterparts who were staying in their homes. Prevention measures such as social distancing, handwashing, and face mask wearing were often difficult to implement in these settings. Current study aimed to assess perspectives of HCPs working in refugee camps on prevention of COVID-19 in camp settings.
Methods
This study was a cross-sectional study and due to movement restriction from March to June 2022, we collected data remotely by sharing a structured questionnaire, in google form, to HCPs via WhatsApp and email. The questionnaire collected HCPs’ perspectives on the feasibility of COVID-19 prevention measures, the prevalence of CIOVID-19 comorbidities, and how the pandemic can be prevented in refugee camp settings. Data were analyzed using descriptive statistics of IBM SPSS V.21.
Results
This study shows that handwashing, social distancing and wearing masks are feasible measures in refugee camp settings, voted by 71 to 100% of the HCPs. However, lockdown or stay home can be hardly applied in such settings, supported by 80.6% of the respondents. Regarding COVID-19 comorbid conditions, pregnant women in their late or recent term and Heart disease like Hypertensive disorders were voted the most common in refugee camps by 56% and 50% of the HCPs, respectively. Steps to COVID-19 prevention in camps include community awareness, preparing and activating the pandemic response task force, stopping non-essential mass gathering activities, and monitoring of COVID-19 prevention measures during essential service delivery.
Conclusions
All in all, except lockdown or stay home, other COVID-19 prevention measures like social distancing, handwashing, and face mask wearing can be easily applied in refugee camp and other similar settings.
Performance Evaluation of Cognitive Relay Networks for End User Mobile Over Mixed Realistic Channels
Authors: Khodeir Mahmoud , Al-Mistarihi Mamoun F. , Ibrahem Lama N. 
Published: July 2022

Abstract
Cognitive relay network is a spectrum dynamic paradigm that exploits the unused portions of the licensed spectrum. This is based on merging both cooperative relaying techniques and cognitive radio network to achieve spectrum efficiency and enhance the overall system performance. In this paper, the presence of mobile users at the destination node is considered. Here, the end users can navigate at relatively fast vehicular velocities causing dynamic multipath fading and high Doppler shift. which can be fairly modeled using Nakagami-m fading channel (i.e., m < 1). In a spectrum scarcity environment, a secondary user must deploy an optimal power allocation policy to get higher transmission rates while the overall interference affecting the primary user (PU) is kept below a certain threshold value. In particular, the outage probability performance is studied over the mixed Rayleigh and Nakagami-m fading channels for different scenarios based on the statistical characteristics of signal-to-noise ratio. The first scenario is the cognitive dual hop amplify and forward relay network over independent and non-identical (i.n.i.d) distributed mixed fading channels. In the second scenario, the cognitive relay network consists of a single amplify and forward relay in addition to the direct link transmission with a selection combining at the destination over i.n.i.d distributed mixed fading channels. Numerical results are presented to evaluate the impact of the fading parameter, m, the maximum aggregated intrusion constraint, and the locations of the primary users (PUs) on different channel scenarios at high vehicular speeds.
New advanced approach for processing natural polymers chitin and guar gum for developing new bioactive biocompatible drug delivery systems for oral administration of insulin
Authors: Sayed howida Abouel Fetouh El , A.Aleem E.E. , Mohammed N. H. , Ismail A. M. 
Published: July 2022

Abstract
Two nanocomposites samples of oral administrations insulin-drug delivery systems: insulin@chitin and insulin@chitin-grafted (g)-guar gum are prepared by using a modified sol-gel method. The novelty of this preparations is that, it is the first time to load insulin vials on such safe ecofriendly natural polymers using water as green solvent. The traces number of chemical agents used in these preparations are below the toxicity limits. Native chitin and chitin-g-guar gum crosslinked copolymer are used as inert bioactive carriers for insulin vials. Guar gum increased the numbers of functional groups of the copolymer. Spectrophotometric monitoring of insulin release at physiological temperature, 37 ± 0.5ºC and buffer solutions pH 1.2, 6.8, 7.4. These tested aqueous solutions simulating biological body fluids of stomach, intestine colon and blood stream. Insulin release from insulin@chitin only at pH 7.4 as monitored by spectrophotometry. No insulin released can be monitored at pH 1.2, and 6.8 due strong bonding of insulin to acetyl group of chitin. In contrast, insulin@chitin- g-guar gum showed sustained targeting insulin-release followed the order: pH 6.8 > pH 7.4 > pH 1.2. The release data obeyed pseudo second order kinetic model indicating that this coplymer is heterogeneous solid surface of energetically different active sites and each insulin molecule occupied two active sites. Slow rate of insulin release at pH 1.2 indicated its protection against stomach juice. The kinetic results and the physicochemical characteristics porosity, swelling ratio, peptide&amino acid sequence, zeta potential, particle size showed that: insulin loaded on chitin by chemisorbed monolayer and it is loaded on the copolymer by chemi-, and phyi-sorption forces. Both insulin@chitin and insulin@chitin-g-GG nanocomposites showed negative zeta potential indicating adequate stability against coagulation. However, insulin@chitin-g-GG nanocomposite showed more monodispersed particle size distribution (than insulin@chitin) enhancing insulin release.
Transcriptomic analysis of alternative splicing associated with crassulacean acid metabolism in pineapple (Ananas comosus)
Authors: Qin Yuan , Li Junzhang , Liao Jingyi , Fang Yunying , Wang Xiaomei , Aslam Mohammad , Cheng Yan , Zheng Ping 
Published: July 2022

Abstract
Crassulacean acid metabolism photosynthesis pathway highlights the possible of sustainable production on margin agricultural land and crop improvement with higher water use efficiency by engineering CAM into C3 crops. A comprehensive view of the regulatory network of CAM photosynthesis is prerequisite for utilization CAM pathway. Diverse factors were involved in the regulation but many of them remain unexplained. Alternative splicing (AS) is a common and crucial posttranscriptional mechanism which get deep involved in responding to biotic and abiotic stresses. Using all the available RNA-seq data of pineapple, which is the most economic valuable CAM crops with abundant omics resource, we re-assembled a reference transcriptome and used to perform alternative splicing analysis associated with crassulacean acid metabolism. The results shown that AS events were prevalent in pineapple. CAM core genes, circadian clock genes, stomatal movement and starch metabolism related genes were found to be significantly differentially alternative spliced between photosynthesis and non-photosynthesis tissues across time course. Isoform switch events were found in many DAS genes, which indicated the sensitivity of AS across the CAM processes in pineapple. The dataset described here also contributed to identify promising candidate genes such as nAco00160 involved in CAM photosynthesis. Our results suggested that AS play an important regulatory role in CAM photosynthesis in pineapple and would help to gain a more systematic understanding about the regulatory networks of CAM photosynthesis.
Biomarkers for Isolated Congenital Heart Disease Based on Maternal Amniotic Fluid Metabolomics analysis
Authors: Yuan Xuelian , Li Lu , Kang Hong , Wang Meixian , Zeng Jing , Lei Yanfang , Li Nana , Yu Ping , Li Xiaohong , Liu Zhen 
Published: July 2022

Abstract
Introduction: Congenital heart disease (CHD) is one of the most prevalence birth defects in the world. The pathogenesis of CHD is complex and unclear. With the development of metabolomics technology, the variations in metabolites may provide a new clue for CHD occurrence and may serve as a biomarker during pregnancy.Method: Maternal amniotic fluid (AF) samples during second and third trimester were utilized to analyze the metabolomics of CHD and normal fetuses. Differential comparison and randomForest were used to screen metabolic biomarkers. Results: A total of 2472 metabolites were detected and they were distributed differentially between the cases and controls. Setting the selection criteria of fold change (FC) ≥ 2, p value < 0.01 and the variable importance for the projection (VIP) ≥ 1.5, we screened out 118 differential metabolites. Within the prediction model by randomForest, PE(MonoMe(11,5)/MonoMe(13,5)), N-feruloylserotonin and 2,6-Di-tert-butylbenzoquinone were showed good prediction effect. Differential metabolites were mainly concentrated in aldosterone synthesis and secretion, drug metabolism, nicotinate and nicotinamide metabolism pathways, which may be related to the occurrence and development of CHD.Conclusion: This study provides a new database on CHD metabolic biomarkers and mechanism research. These results need to be further verified in larger samples.
Reconstructing NDVI and land surface temperature from cloud cover pixels of Landsat-8 images and assessing vegetation health index in the Northeast region of Thailand
Authors: Mohanasundaram S. , Baghel Triambak , Thakur Vishal , Udmale Parmeshwar , Shrestha Sangam 
Published: July 2022

Abstract
Critical applications of satellite data products include monitoring vegetation dynamics using vegetation indices such as Normalized Difference Vegetation Index (NDVI) and thermal characteristics such as Land Surface Temperature (LST) variations across different spatial and temporal scales. One of the major problems with passive remote sensing satellite data products is cloud and shadow cover that void the information from a specific image. The cloud cover problems further amplified during monsoon seasons as the formation of clouds are more frequent during these seasons. The present study proposes temporal aggregation of images and developing Harmonic Analysis of Time Series (HANTS) and Pixel-wise Multiple Linear Regression (PMLR) algorithms for retrieving cloud contaminated NDVI and LST information from Landsat-8 (L8) data products, respectively. The developed algorithms were applied in the northeastern part of Thailand to recover the missing NDVI and LST values from time series of L8 images acquired in 2018. The predicted NDVI and LST values at artificially clouded locations were compared with the corresponding clear pixel values. Additionally, the model predicted LST and NDVI values were also compared with MODIS LST and NDVI data sets. The calculated root mean square (RMSE) values were ranging from 0.004 to 0.05 and 1.05°C to 3.11°C for NDVI and LST variables, respectively. The validation statistics show that these models can be satisfactorily applied to retrieve NDVI and LST values from cloud-contaminated pixels of L8 images. Furthermore, a vegetation health index (VHI) calculated at province level show that most of the western provinces showed a healthy vegetation condition than other provinces in the northeast of Thailand.