bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association Between Wisdom and Psychotic-Like Experiences in the General Population: A Cross-Sectional Study
Authors: Wu Zhipeng , Jiang Zhengqian , Wang Zhipeng , Ji Yuqiao , Wang Feiwen , Ross Brendan , Sun Xiaoqi , Liu Zhening , Long Yicheng 
Published: April 2022

IntroductionWisdom has been empirically researched as a complex psychological characteristic that is associated with many mental health outcomes. However, its association with psychotic-like experiences (PLEs) remains unclear. This is the first work to assess wisdom, explore its association with PLEs, and test its moderating effect on the relation between the frequency of PLEs and their associated distress in the general population.MethodsFrom January 29th to February 5th, 2021, our online self-administered survey recruited 927 participants (ages 14 to 65) from thirteen Chinese provinces. Convenience sampling was employed. We measured wisdom with the 12-item three-dimensional wisdom scale (3D-WS-12) and PLEs with the 15-item positive subscale of the Community Assessment of Psychic Experiences (CAPE-P15).ResultsUsing the cut-off value of 1.47 in the mean frequency score, we divided our participants into high-PLEs group (188, 22.1%) and low-PLEs group (663, 77.9%). Three-dimensional wisdom score was decreased in the high-PLEs group compared to the low-PLEs group (Kruskal-Wallis t = 59.9, p &lt; 0.001). Wisdom was associated with less frequent PLEs (Spearman’s rho = −0.21, p &lt; 0.01) and lower distress related to PLEs (Spearman’s rho = −0.28) in the high-PLEs group (all above p &lt; 0.001), which were replicated in the low-PLEs group. Notably, wisdom significantly attenuated the distress associated with PLEs [coefficient = −0.018, Bootstrap 95% CI (−0.029, −0.008)], but only in the low-PLEs group.ConclusionOur results implicated that wisdom could protect individuals from distressful subclinical psychotic symptoms and wiser individuals have better general mental health.
Structure of Hypomanic Symptoms in Adolescents With Bipolar Disorders: A Network Approach
Authors: Yang Yuan , Zhang Wu-Yang , Zhang Yao , Li Shuying , Cheung Teris , Zhang Dexing , Jackson Todd , He Fan , Xiang Yu-Tao 
Published: April 2022

BackgroundBipolar disorders (BD) are severe mental illnesses that are often misdiagnosed or under-diagnosed. The self-report 33-item Hypomania Checklist (HCL-33) and the 33-item Hypomania Checklist – external assessment (HCL-33-EA) are well-validated scales for BD symptom detection. This study compared the network structure, central symptoms, and network stability of hypomanic symptoms measured by the HCL-33 vs. the HCL-33-EA.MethodsThis cross-sectional study was conducted from January to December 2019. Adolescents (aged between 12 and 18 years) with BD were recruited from the outpatient department of Child Psychiatry, First Affiliated Hospital of Zhengzhou University. All participants were asked to complete the HCL-33, and their caregivers completed the HCL-33-EA. Network analyses were conducted.ResultsA total of 215 adolescents with BD and their family caregivers were recruited. Node HCL17 (“talk more,” node strength = 4.044) was the most central symptom in the HCL-33 network, followed by node HCL2 (“more energetic,” node strength = 3.822), and HCL18 (“think faster,” node strength = 3.801). For the HCL-33-EA network model, node HCL27 (“more optimistic,” node strength = 3.867) was the most central node, followed by node HCL18 (“think faster,” node strength = 3.077), and HCL17 (“talk more,” node strength = 2.998). In the network comparison test, there was no significant difference at the levels of network structure (M = 0.946, P = 0.931), global strength (S: 5.174, P = 0.274), or each specific edge (all P’s &gt; 0.05 after Holm–Bonferroni corrections) between HCL-33 and HCL-33-EA items. Network stabilities for both models were acceptable.ConclusionThe nodes “talk more” and “think faster” acted as central symptoms in BD symptom network models based on the HCL-33 and HCL-33-EA. Although the most prominent central symptom differed between the two models (“talk more” in HCL-33 vs. “more optimistic” in HCL-33-EA model), networks based on each measure were highly similar and underscored similarities in BD symptom relations perceived by adolescents and their caregivers. This research provides foundations for future studies with larger sample sizes toward improving the accuracy and robustness of observed network structures.
Deciphering Risperidone-Induced Lipogenesis by Network Pharmacology and Molecular Validation
Authors: Fu Yun , Yang Ke , Huang Yepei , Zhang Yuan , Li Shen , Li Wei-Dong 
Published: April 2022

BackgroundRisperidone is an atypical antipsychotic that can cause substantial weight gain. The pharmacological targets and molecular mechanisms related to risperidone-induced lipogenesis (RIL) remain to be elucidated. Therefore, network pharmacology and further experimental validation were undertaken to explore the action mechanisms of RIL.MethodsRILs were systematically analyzed by integrating multiple databases through integrated network pharmacology, transcriptomics, molecular docking, and molecular experiment analysis. The potential signaling pathways for RIL were identified and experimentally validated using gene ontology (GO) enrichment and Kyoto encyclopedia of genes and genomes (KEGG) analysis.ResultsRisperidone promotes adipocyte differentiation and lipid accumulation through Oil Red O staining and reverse transcription-polymerase chain reaction (RT-PCR). After network pharmacology and GO analysis, risperidone was found to influence cellular metabolism. In addition, risperidone influences adipocyte metabolism, differentiation, and lipid accumulation-related functions through transcriptome analysis. Intersecting analysis, molecular docking, and pathway validation analysis showed that risperidone influences the adipocytokine signaling pathway by targeting MAPK14 (mitogen-activated protein kinase 14), MAPK8 (mitogen-activated protein kinase 8), and RXRA (retinoic acid receptor RXR-alpha), thereby inhibiting long-chain fatty acid β-oxidation by decreasing STAT3 (signal transducer and activator of transcription 3) expression and phosphorylation.ConclusionRisperidone increases adipocyte lipid accumulation by plausibly inhibiting long-chain fatty acid β-oxidation through targeting MAPK14 and MAPK8.
Identification of Common Hub Genes in Human Dermal Fibroblasts Stimulated by Mechanical Stretch at Both the Early and Late Stages
Authors: Dong Chen , Liu Wei , Zhang Yu , Song Yajuan , Du Jing , Huang Zhaosong , Wang Tong , Yu Zhou , Ma Xianjie 
Published: April 2022

BackgroundMechanical stretch is vital for soft tissue regeneration and development and is utilized by plastic surgeons for tissue expansion. Identifying the common hub genes in human dermal fibroblasts (HDFs) stimulated by mechanical stretch at different stages will help elucidate the mechanisms involved and improve the efficiency of tissue expansion.MethodsA gene expression dataset (GSE58389) was downloaded from the Gene Expression Omnibus database. Differentially expressed genes (DEGs) in HDFs between cyclic mechanical stretching and static samples were identified at 5 and 24 h. Common DEGs overlapped in both the 5 h and 24 h groups. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses were performed to determine the functions of the DEGs. Protein-protein interaction networks were constructed using the STRING database. The top 10 hub genes were selected using the plug-in Cytohubba within Cytoscape. The regulatory network of hub genes was predicted using NetworkAnalyst.ResultsA total of 669 and 249 DEGs were identified at the early (5 h) and late stages (24 h), respectively. Of these, 152 were present at both stages and were designated as common DEGs. The top enriched GO terms were “regulation of autophagy” at the early stage, and “sterol biosynthetic processes” at the late stage. The top KEGG terms were “pyrimidine metabolism” and “synaptic vesicle cycle” at the early and late stages, respectively. Seven common DEGs [DEAD-box helicase 17 (DDX17), exocyst complex component 7 (EXOC7), CASK interacting protein 1 (CASKIN1), ribonucleoprotein PTB-binding 1 (RAVER1), late cornified envelope 1D (LCE1D), LCE1C, and polycystin 1, transient receptor potential channel interacting (PKD1)] and three common DEGs [5′-3′ exoribonuclease 2 (XRN2), T-complex protein 1 (TCP1), and syntaxin 3 (STX3)] were shown to be downregulated and upregulated hub genes, respectively. The GO terms of the common hub genes were “skin development” and “mRNA processing.” After constructing the regulatory network, hsa-mir-92a-3p, hsa-mir-193b-3p, RNA polymerase II subunit A (POLR2A), SMAD family member 5 (SMAD5), and MYC-associated zinc finger protein (MAZ) were predicted as potential targets in both stages.ConclusionAt the early stage, there were clear changes in gene expression related to DNA and chromatin alterations; at late stages, gene expression associated with cholesterol metabolism was increased. Common DEGs related to skin development, transcriptional regulation, and cytoskeleton rearrangement identified in both stages were found to be potential targets for promoting HDF growth and alignment under mechanical stretch.
Features of Treatment of Children with Tonsils Hypertrophy
Authors: Якимцова А.В. , Песоцкая М.В. , Куницкий В.С. 
Published: April 2022

Гипертрофия небных миндалин (ГНМ) представляет собой актуальную проблему детской оториноларингологии в связи с широкой распространенностью данной патологии у детей и ее последствиями. Увеличение небных миндалин существенно ухудшает качество жизни, так как сопровождается затруднением носового дыхания, синдромом обструктивного апноэ сна, кашлем, голосо-речевыми нарушениями, ринолалией, повышенным рвотным рефлексом, воспалительными изменениями со стороны верхних дыхательных путей. Многообразие хирургических методов, предложенных для лечения данной патологии, не исключает риска развития интра- и послеоперационных осложнений, вплоть до летального исхода. Таким образом, поиск новых методов хирургического лечения пациентов с гипертрофией небных миндалин IIIII степени, позволяющих достичь запланированного клинического результата с минимальным риском осложнений, является важной практической задачей современной оториноларингологии. В статье рассмотрены вопросы эпидемиологии и этиология развития гипертрофии небных миндалин, существующие хирургические методы лечения и представлены результаты использования метода лазерной фотокоагуляции небных миндалин при их гипертрофии у детей, проходивших лечение в оториноларингологическом отделении УЗ ВОДКЦ за период с 01.01.2017 по 01.07.2019 г.
Hypertrophy of palatine tonsils is an urgent problem of pediatric otorhinolaryngology due to both the widespread prevalence of this pathology and its consequences. An increase in palatine tonsils significantly worsens the quality of life, as it is accompanied by difficulty in nasal breathing, obstructive sleep apnea syndrome, coughing, impaired speech and diction, nasal voices, and an increased gag reflex. The variety of surgical methods proposed for the treatment of this pathology does not exclude postoperative complications, including death. Thus, the search for new methods of surgical treatment of patients with hypertrophy of palatine tonsils II-III degree, allowing to achieve the planned clinical result with minimal risk of complications, is an important task of modern otorhinolaryngology. The article discusses the epidemiology and etiology of hypertrophy of palatine tonsils, the existing surgical methods of treatment, and presents the results of using laser photocoagulation of palatine tonsils with their hypertrophy in children undergoing treatment at the Vitebsk Regional Childrens Clinical Center for the period from 01.01.2017 to 01.07.2019.
The Role of Laryngeal Ultrasound in the Assessment and Treatment of Functional Dysphonia
Authors: Криштопова М.А. , Петрова Л.Г. , Гирса В.Н. 
Published: April 2022

Цель исследования: повышение эффективности диагностики и объективизации эффекта комплексного лечения пациентов с функциональными дисфониями с помощью УЗИ гортани. Материалы и методы: исследование гортани с помощью УЗИ проводилось здоровым лицам без дисфонии (n10) и пациентам с функциональной дисфонией/афонией (n20). Основными видами лечения пациентов были комплексное медикаментозное лечение и фонопедия (G1, n10) или фонопедия с ультразвуковой биологической обратной связью (G2, n10). Результаты: УЗИ гортани в B-режиме и в режиме доплерографии с фонаторными пробами позволяет визуализировать нарушение координации работы мышц гортани в виде напряжения вестибулярного отдела гортани, ограничения подвижности, наличия неполного смыкания и отсутствие вибрации голосовых складок при фонации. Более быстрое и стойкое восстановление голоса наблюдалось в группе пациентов, получавших комплексное медикаментозное лечение и фонопедию с ультразвуковой биологической обратной связью, по сравнению с группой пациентов, получавших комплексное медикаментозное лечение и фонопедию без ультразвуковой биологической обратной связи (p0,005). Заключение: УЗИ гортани в B-режиме и режиме доплерографии с фонаторными пробами позволяет глубже понять патофизиологические процессы функциональной дисфонии. Фонопедическое лечение с биологической обратной связью является эффективным методом лечения функциональной дисфонии.
The purpose of the study is to improve diagnosis and treatment of patients with functional dysphonia by using ultrasound of the larynx. Materials and methods. Larynx ultrasonography was performed to healthy people without dysphonia (n10) and patients with functional dysphonia/aphonia (n20). Complex medication therapy and oropharyngeal muscle exercise therapy without ultrasound biofeedback (G1, n10) or oropharyngeal muscle exercise therapy with ultrasound biofeedback (G2, n10) were used. Results. Larynx ultrasonography is a minimally invasive, easily reproducible, and inexpensive method of laryngeal examining. It may become a perfect tool for functional dysphonia identification with its later monitoring. The group of patients receiving complex medication therapy and oropharyngeal muscle exercise therapy with ultrasound biofeedback compared to the group of patients without ultrasound biological feedback had significantly higher functional results (p0.005). Conclusion. Larynx ultrasonography is a perfect tool for understanding the pathophysiology of functional dysphonia. Oropharyngeal muscle exercise therapy with ultrasound biofeedback is an effective treatment tool for functional dysphonia.
DISTRIBUSI DAN PENGGUNAAN HABITAT EMPAT SPESIES FELIDAE DI TAMAN NASIONAL BUKIT BARISAN SELATAN
Authors: Supartono Toto , Nasihin Iing , Tawaqal Feizal 
Published: April 2022

The polulation of Cat Family (Felidae) in Southeast Asia has declined in nature owing to its lost habitat, fragmentation one and massive hunting. Meanwhile, the research of Asiatic Golden Cats, Sunda Clouded Leopards, Marbled Cats, and Asian Leopard Cats is not much conducted. This research aimed to find out their distribution and habitat use in Southern Bukit Barisan National Park (BBSNP). The data intake employed Camera Trap, then analyzed by occupancy model with single season and single species applying R-software. It was found that Asiatic Golden Cat Occupancy Model yielded 0.75 in Intensive Protection Zone or Zona Perlindungan Intensive (IPZ) and 0.4 occupancy value in northen parts of Sourthern Bukit Barisan National Park (BBSNP). Furthermore, its Sunda Clouded Leopards resulted in 0.50 in IPZ and 0.42 occupancy value in northen parts of BBSNP. Its Asian Leopard Cats was 0.16 occupancy value in IPZ and unexecuted occupancy model in northen parts of BBSNP due to extremly low detection.
Leadership Development in the Flow of Work: Leveraging Technology to Accelerate Learning
Authors: Young Stephen , Diaz Jessica , De Coutere Bert , Downs Holly 
Published: April 2022

"A recent industry trend survey of CEOs found that only 11% of organizations report having a strong enough bench to fill leadership roles (Rhyne, 2021). As such, effective leadership development is an imperative for any high-performing organization. Rather than focusing time, money, and energy on only a small subset of “high-potential” employees, organizations can realize the full potential of their entire workforce by providing tech-enabled leadership development to leaders at all levels. This paper shares the following insights for Chief Learning Officers interested in leveraging evidence-based practices to accelerate leader development at scale and unlock the collective potential of their workforce: •	A brief overview of why we need new ways to develop leaders and a high-level description of the new digital assessment and development tools that meet individuals where they are – offering a highly personalized approach to development in-the-flow of work. •	A review of eight research-based learning practices that provide a foundation for leveraging technology to make in-the-flow leadership development better, faster, and more accessible to leaders at all levels. For every learning practice, we provide implementation tips and discuss illustrative example tools. •	We conclude with a discussion around the strategic use of the eight learning practices for enabling better organization-wide development outcomes. "
Methodological aspects of the detection of minimal residual disease in patients with acute leukemia
Authors: Galtseva I. V. , Smirnova S. Y. , Parovichnikova E. N. 
Published: April 2022

Introduction. The study of minimal residual disease (MRD) has become an integral part of various treatment protocols for acute leukemia. Methods of polymerase chain reaction (PCR) and multicolor fl ow cytometry (MFC) are most widely used to assess MRD.Aim — to characterize the main technologies for the detection of residual tumor cells in acute leukemiaMain findings. Various approaches for detecting MRD are described: PCR with patient-specifi c primers for rearranged genes of immunoglobulin and/or T-cell receptors, reverse transcription PCR for detecting chimeric transcripts and assessing the expression of overexpressed genes, as well as the basics of detecting MRD by MFC. Each of these approaches has its own advantages, disadvantages, and limitations of use.
Blood groups and acute respiratory viral infection COVID-19
Authors: Zubareva L. M. , Donskov S. I. 
Published: April 2022

Introduction. Polysaccharides, glycoproteins and glycolipids, which determine the group-specifi c properties of human blood, are both structural elements of the whole organism and determine its predisposition to certain somatic and infectious diseases. Thus, the blood group of an individual can be used among other markers and/or prognostic factors of the occurrence and course of certain groups of diseases.Aim — analysis of literature sources characterizing the relationship of blood groups with COVID-19 ARVI, as well as the mechanisms underlying this relationship.Main findings. The Oaß(I) phenotype ensures an individual’s resistance to infection with the SARS-CoV-2 virus and allows for a relatively mild course of the disease. The Aß (II) phenotype is a risk factor for the development of COVID-19 ARVI, in its severe course, the occurrence of complications and increased mortality. An additional component of protection in the form of a negative Rh-affi liation of the infected person is not excluded. The protective properties of the Oaß(I) phenotype are associated with the absence of polysaccharide A in an individual and the presence of anti-A antibodies. The increased risk of COVID-19 ARVI among Aß (II) individuals is due to the large polymorphism of polysaccharide A in the environment and the lack of natural immunity to other forms of polysaccharide A in this group.
Use of eltrombopag in treatment programs for patients with aplastic anemia
Authors: Mikhailova E. A. , Luchkin A. V. , Abramova A. V. , Fidarova Z. T. , Troitskaya V. V. , Dvirnyk V. N. , Galtseva I. V. , Kovrigina A. M. , Alimova G. A. , Obukhova T. N. , Abramova T. V. , Parovichnikova E. N. , Savchenko V. G. 
Published: April 2022

Introduction. The use of thrombopoietin receptor agonists, especially eltrombopag, in the treatment of aplastic anemia (AA) patients who did not respond to the previous immunosuppressive therapy (IST), is accompanied by the development of a hematological response in 40–60 % of patients.Aim — to study the effi cacy of using eltrombopag in treatment programs for AA patients refractory to previous IST.Methods. The study included 20 AA patients who were treated at the National Research Center for Hematology from 2015 to 2020. These patients did not respond to the conducted IST (ATG + CsA). Eltrombopag was administered at a dose of 150 mg/day. The results of treatment were assessed at 3 and 6 months: the achievement of hematological improvement, partial and complete remission, as well as the identifi cation of possible clonal evolution were determined.Results. Eleven out of 20 (55 %) patients responded to treatment: 2 patients developed hematological improvement, 6 patients — partial remission, 3 patients — complete remission. All 11 patients responded to treatment within 12 months from the start of eltrombopag, but further positive dynamics of hematological parameters are possible. The median duration of treatment with eltrombopag was 11 (1–48) months. Most of the patients were treated with eltrombopag in combination with CsA. The duration of the course of treatment with eltrombopag depended on the response received (stable hematological improvement, remission, as well as the detection of clonal evolution) or its absence and the need for ATG or BMT. An aberrant karyotype was found in 2 AA patients who received eltrombopag: in one patient monosomy of chromosome 7 was detected 1 month after the start of treatment, in another patient, 37 months later, a clone with a derivative of chromosome 16 from t(1;16) and subclone with complex disorders of the karyotype without signs of myelodysplasia in the bone marrow.Conclusion. The inclusion of the TPO receptor agonist eltrombopag in the treatment program for AA patients allows for a stable hematological response and remission of AA for patients who have not responded to IST. The effectiveness of eltrombopag is determined by adherence to the treatment algorithm, the optimal duration of the course, and the dose of the drug used. There is still a need for long-term observation of the patient and control morphological and cytogenetic studies.