bluuebunny/crossref_metadata_2025_split huggingface dataset:
Detrital zircon provenance of the Cretaceous–Neogene East Coast Basin reveals changing tectonic conditions and drainage reorganization along the Pacific margin of Zealandia
Authors: Gooley Jared T. , Nieminski Nora M. 
Published: February 2022

Abstract
The Upper Cretaceous–Pliocene strata of New Zealand record ~100 m.y. of Zealandia's evolution, including development of the Hikurangi convergent margin and Alpine transform plate boundary. A comprehensive, new detrital zircon U-Pb data set (8315 analyses from 61 samples) was generated along a ~700 km transect of the East Coast Basin of New Zealand. Age distributions were analyzed and interpreted in terms of published data available for Cambrian–Cretaceous igneous and metasedimentary source terranes using a Monte Carlo mixture modeling approach. Results indicate a widespread Early Cretaceous transition in sediment source from the Gondwana interior to the Median Batholith magmatic arc prior to Late Cretaceous rifting from Antarctica. Submergence of Zealandia during a Late Cretaceous–Paleogene drift phase led to major drainage reorganization and the influx of Eastern Province sediment to the East Coast Basin. A long-lived sediment conduit that transported extraregional Western Province detritus to the south-central East Coast Basin may have developed along a structural precursor to the Alpine Fault. Marked Neogene increase of Upper Jurassic–Lower Cretaceous Torlesse Composite Terrane sediment to the central East Coast Basin resulted from exhumation of the Axial Ranges, convergence along the Hikurangi subduction margin, and concurrent development of the Alpine Fault. Concurrent influx of contemporaneous Neogene zircon in the northern East Coast Basin indicated the onset of subduction-related volcanism of the Northland–Coromandel Volcanic Arc. Middle Miocene–Pliocene exhumation and dextral translation of the Nelson region along the Alpine Fault resulted in the eastward routing of Western Province sediment to the central East Coast Basin. Finally, topography developed across the plate boundary and ultimately partitioned continental drainage of Zealandia, such that sediment from the Murihiku, Caples, and Rakaia Terranes in the Otago region was routed to the southern extent of the East Coast Basin. These results illuminate the evolution of the Zealandia continental drainage divide in response to the initiation of the Pacific-Australian plate boundary and demonstrate the power of mixture modeling and large data sets for deciphering sediment routing in dynamic tectonic environments.
Bone-targeting agents in major solid tumour metastases: a multinational cohort study
Authors: Kim Ju Hwan , Shen Chin-Yao , Au Philip Chun-Ming , Baek Yeon-Hee , Cheung Ching-Lung , Chung Wei-Pang , Kleinman Nora Joelle , Lam Tai Chung , Liao Tzu-Chi , Lin Tzu-Chieh , Shin Ju-Young , Sing Chor-Wing , Wong Ian Chi Kei , Lai Edward Chia-Cheng 
Published: February 2022

ObjectiveTo describe the epidemiology, clinical characteristics and utilisation patterns of bone-targeting agents (BTAs) in patients with bone metastases from breast, prostate and lung cancer.MethodsThis is a multinational retrospective cohort study including patients with three major solid tumours (breast, prostate and lung cancer) and newly initiated on BTAs (ie, denosumab, zoledronic acid and pamidronate). Records were retrieved from nationwide health databases from Hong Kong and Taiwan (HK and TW: 2013–2017) and Korea (KR: 2012–2016). Descriptive analyses included the annual incidence rates of bone metastases and the cumulative incidence curves of BTA initiation. We used Sankey diagrams to visualise the dynamic BTA utilisation patterns.ResultsThe annual incidence rate of bone metastases ranged from 3.5% to 4.5% in TW, from 9.6% to 10.3% in HK and from 2.9% to 3.8% in KR. We identified 14.1% (5127), 9.3% (883) and 9.4% (4800) of patients with bone metastases newly initiated on BTAs in TW, HK and KR, respectively. The most frequently used BTA in TW (67.1%) and HK (51.9%) was denosumab, while in KR (84.8%) it was zoledronic acid. Sankey diagrams indicated the proportion of patients remaining on denosumab was highest in TW and HK, while it was zoledronic acid in KR. Specifically, in TW, patients who were on bisphosphonates or had discontinued treatment frequently switched to or reinitiated denosumab.ConclusionsWe found the rate of BTA utilisation remained low across all sites and tumour types in recent years. The dynamic utilisation patterns of BTAs provide better understanding of the treatment landscape for future evaluation of associated outcomes of patients.
Surgical Treatment of Ulnar Cleft Hand with All Fingers – A Report of Two Patients
Authors: NAKAGAWA Keisuke , TAKAYAMA Shinichiro , HIDAKA Noriaki , NAKAMURA Hiroaki 
Published: February 2022

An ulnar cleft hand is a rare congenital deformity presenting with a cleft between the ring and little finger. It may be associated with the absence of a finger. The goals of treatment are cleft closure, increasing the length of the hypoplastic little finger and preservation of function. We report two patients with ulnar cleft hand without missing fingers. Both underwent cleft closure. One was treated by lengthening of the fifth metacarpal with an external fixator, and the other by finger translocation. Both patients achieved a near normal length of the little finger and a reasonable functional and aesthetic outcome. Level of Evidence: Level V (Therapeutic)
Slips of the tongue and what to do about them
Authors: Yaffe Philip 
Published: February 2022

Each "Communication Corner" essay is self-contained; however, they build on each other. For best results, before reading this essay and doing the exercise, go to the first essay "How an Ugly Duckling Became a Swan," then read each succeeding essay.
One of the most dreaded hobgoblins of public speaking is the pervasive fear that you will say something you didn't really mean to say. This is indeed a problem, but perhaps much less so than you might imagine.
Reciclagem e gestão do ambiente urbano: o trabalho dos catadores de resíduos sólidos na metrópole paulistana em tempos de políticas neoliberais
Authors: Marques Marta Inez Medeiros 
Published: February 2022

A atividade de coleta de resíduos sólidos, tradicionalmente desenvolvida por um dos segmentos mais precarizados da classe trabalhadora nas cidades, tem sido alvo de um conjunto de mudanças, e a criação do Movimento Nacional de Catadores de Recicláveis em 2001, bem como a aprovação da Política Nacional de Resíduos Sólidos (Lei nº 12.305/2010) no final governo Lula, é evidência disso. O objetivo deste artigo é analisar os fundamentos dessas mudanças e as suas relações com transformações recentes observadas no mundo do trabalho e na gestão pública, bem como com o crescente apelo político e mercadológico exercido pela defesa da sustentabilidade ambiental, a partir do estudo do que ocorre na cidade de São Paulo. Em tempos de crise ambiental e do trabalho, dentre outras crises, além dos resíduos sólidos, reciclam-se discursos, políticas e práticas econômicas
La mélodie française comme témoignage d’une réception : le cas d’invocation
Authors: Pasini Lucia 
Published: February 2022

Tout au long de cet article, j’esquisse en première instance les contours d’un appareil conceptuel afin de définir les termes dans lesquelles je situe mon travail, et je montre ensuite par le biais de l’exemple d’Invocation à quel point la prise en compte du genre mélodique dans une optique littéraire s’avère fructueuse. L’analyse de cet exemple est à son tour divisée en deux parties : une première où il est question de situer la mélodie dans son contexte de production, et une deuxième où l’on se tourne effectivement vers le morceau et ses caractéristiques particulières. En proposant un appareil conceptuel pour concevoir littérairement la mélodie française, je m’appuie sur trois pôles théoriques de références, dont la provenance est hétérogène, à savoir : la théorie de la réception ; la notion de « fenêtre herméneutique », telle que la présente Lawrence Kramer ; et la notion de « réseau des textes possibles », telle qu’en parle Michel Charles. Ensuite, je présente un exemple isolé pour montrer le potentiel d’une conception littéraire de la mélodie française comme témoignage de la réception par les compositeurs des textes poétiques qu’ils choisissent pour leurs morceaux.
Transforming Lord’s Supper: Indonesian Protestant Responses to the Covid-19 Pandemic
Authors: Iwamony Rachel 
Published: February 2022

Abstract
By focusing on the issue of the Lord’s Supper, this article explores the contextual theological responses of three Protestant churches in the eastern part of Indonesia towards the Covid-19 pandemic. The article argues that discourses on the Lord’s Supper in response to the pandemic reflected the mission theology of these communities in terms of their beliefs (doctrine) and practices (rites, structures, order, community). Through online interviews and document analysis, the researcher discovered that churches made significant contextual transformations during the first period of the pandemic. The pandemic challenged these churches to make significant theological responses to fulfill their mission. They changed traditional rituals to adapt to distancing guidelines. In contrast to the belief in the importance of church buildings, the homes of church members were transformed into church-centers. Solidarity among congregational members was stronger than before the pandemic, with ways for members to contact and support each other from home.
The lncRNA DANCR promotes development of atherosclerosis by regulating the miR-214-5p/COX20 signaling pathway
Authors: Zhang Ruolan , Hao Yuming , Zhang Jinrong 
Published: February 2022

Abstract
Background
Although long non-coding RNA differentiation antagonizing non-protein coding RNA (DANCR) has been reported to be involved in atherosclerosis (AS) development, its specific mechanism remains unclear.

Methods
DANCR expression levels in blood samples of AS patients and oxidized low-density lipoprotein (ox-LDL) treated vascular smooth muscle cells (VSMCs) and human umbilical vein endothelial cells (HUVECs) were detected by quantitative real-time polymerase chain reaction (qRT-PCR). The small interfering RNA targeting DANCR (si-DANCR) was used to silence DANCR expression. Cell viability was assessed by CCK-8 assay. Cell apoptosis was evaluated by flow cytometry. Levels of inflammatory cytokines, anti-oxidative enzyme superoxide dismutase (SOD) activity, and malonaldehyde (MDA) were detected by specific commercial kits. An animal AS model was established to confirm the role of DANCR/microR-214-5p/COX20 (the chaperone of cytochrome c oxidase subunit II COX2) in AS development.

Results
DANCR was significantly increased in the blood samples of AS patients and ox-LDL treated VSMCs and HUVECs. DANCR downregulation obviously increased viability and reduced apoptosis of ox-LDL-treated VSMCs and HUVECs. Meanwhile, DANCR downregulation reduced the levels of inflammatory cytokines, including interleukin (IL)-6 (IL-6), IL-1beta (IL-1β), IL-6 and tumor necrosis factor (TNF)-alpha (TNF-α) and MDA while increasing the SOD level in ox-LDL-treated VSMCs and HUVECs. DANCR regulated COX20 expression by acting as a competing endogenous RNA (ceRNA) of miR-214-5p. Rescue experiments demonstrated that miR-214-5p downregulation obviously attenuated si-DANCR-induced protective effects on ox-LDL-caused endothelial injury.

Conclusions
Our results revealed that DANCR promoted AS progression by targeting the miR-214-5p/COX20 axis, suggesting that DANCR might be a potential therapeutic target for AS.
Analysis of gene expression in early seed germination of rice: landscape and genetic regulation
Authors: Li Haoxuan , Li Xiaozheng , Wang Guanjie , Zhang Jianhua , Wang Guanqun 
Published: February 2022

Abstract
Background
Seed germination is a crucial process, which determines the initiation of seed plant life cycle. The early events during this important life cycle transition that called early seed germination is defined as initially water uptake plus radicle growing out of the covering seed layers. However, a specific genome-wide analysis of early seed germination in rice is still obscure.

Results
In this study, the physiological characteristics of rice seed during seed germination are determined to define key points of early seed germination. Transcriptome analyses of early phase of seed germination provided deeper insight into the genetic regulation landscape. Many genes involved in starch-to-sucrose transition were differentially expressed, especially alpha-amylase 1b and beta-amylase 2, which were predominantly expressed. Differential exon usage (DEU) genes were identified, which were significantly enriched in the pathway of starch and sucrose metabolism, indicating that DEU events were critical for starch-to-sucrose transition at early seed germination. Transcription factors (TFs) were also dramatic expressed, including the abscisic acid (ABA) responsive gene, OsABI5, and gibberellic acid (GA) responsive genes, GAI. Moreover, GAI transactivated GA responsive gene, GAMYB in vivo, indicating a potential pathway involved in early seed germination process. In addition, CBL-interacting protein kinase (CIPK) genes, such as CIPK13, CIPK14 and CIPK17 were potentially interacted with other proteins, indicating its pivotal role at early seed germination.

Conclusion
Taken together, gene regulation of early seed germination in rice was complex and protein-to-gene or protein-to-protein interactions were indispensable.
Mapping and ablation of left atrial roof-dependent tachycardias using an ultra-high resolution mapping system
Authors: Miyazaki Shinsuke , Hasegawa Kanae , Yamao Kazuya , Ishikawa Eri , Mukai Moe , Aoyama Daisetsu , Nodera Minoru , Yamaguchi Junya , Shiomi Yuichiro , Tama Naoto , Ikeda Hiroyuki , Fukuoka Yoshitomo , Ishida Kentaro , Uzui Hiroyasu , Iesaka Yoshito , Tada Hiroshi 
Published: February 2022

Abstract
Background
Left atrial roof-dependent tachycardias (LARTs) are common macroreentrant atrial tachycardias (ATs). We sought to characterize clinical LARTs using an ultra-high resolution mapping system.

Methods
This study included 22 consecutive LARTs in 21 patients who underwent AT mapping/ablation using Rhythmia systems.

Results
Three, 13, 4, and 2 LART patients were cardiac intervention naïve (Group-A), post-roof line ablation (Group-B), post-atrial fibrillation ablation without linear ablation (Group-C), and post-cardiac surgery (Group-D), respectively. The mean AT cycle length was 244 ± 43 ms. Coronary sinus activation was proximal-to-distal or distal-to-proximal in 16 (72.7%) ATs. The activation map revealed 13 (59.1%) clockwise and 9 (40.9%) counter-clockwise LARTs. A 12-lead synchronous isoelectric interval was observed in 10/19 (52.6%) LARTs. The slow conduction area was identified on the LA roof, anterior/septal wall, and posterior wall in 18, 6, and 2 ATs, respectively. Twenty concomitant ATs among 13 procedures were also eliminated, and peri-mitral AT coexisted in 7 of 9 non-group-B patients. In group-B, the conduction gap was predominantly located on the mid-roof. Sustained LARTs were terminated by a single application and linear ablation in 6 (27.3%) and 9 (40.9%), while converting to other ATs in 7 (31.8%) LARTs. Complete linear block was created without any complications in all, however, ablation at the mid-posterior wall was required to achieve block in 4 (18.2%) procedures. During 14.0 (6.5–28.5) months of follow-up, 17 (81.0%) and 19 (90.5%) patients were free from any atrial tachyarrhythmias after single and last procedures.

Conclusions
The LART mechanisms were distinct in individual patients, and elimination of all concomitant ATs was required for the management.
Chronic diseases, chest computed tomography, and laboratory tests as predictors of severe respiratory failure and death in elderly Brazilian patients hospitalized with COVID-19: a prospective cohort study
Authors: Junior Alberto Frisoli , Azevedo Elaine , Paes Angela Tavares , Lima Eliene , Campos Guerra João Carlos , Ingham Sheila Jean Mc Neill 
Published: February 2022

Abstract
Background
The primary risk factors for severe respiratory failure and death in the elderly hospitalized with COVID-19 remain unclear.

Objective
To determine the association of chronic diseases, chest computed tomography (CT), and laboratory tests with severe respiratory failure and mortality in older adults hospitalized with COVID-19.

Method
This was a prospective cohort with 201 hospitalized older adults with COVID-19. Chronic diseases, chest CT, laboratory tests, and other data were collected within the first 48 h of hospitalization. Outcomes were progression to severe respiratory failure with the need of mechanical ventilation (SRF/MV) and death.

Results
The mean age was 72.7 ± 9.2 years, and 63.2% were men. SRF/MV occurred in 16.9% (p < 0.001), and death occurred in 8%. In the adjusted regression analyses, lung involvement over 50% [odds ratio (OR): 3.09 (1.03–9.28; 0.043)], C-reactive protein (CRP) > 80 ng/mL [OR: 2.97 (0.99–8.93; 0.052)], Vitamin D < 40 ng/mL [OR: 6.41 (1.21–33.88; 0.029)], and hemoglobin < 12 g/mL [OR: 3.32 (1.20–9.20; 0.020)] were independent predictors for SFR/MV, while chronic atrial fibrillation [OR: 26.72 (3.87–184.11; 0.001)], cancer history [OR:8.32 (1.28–53.91; 0.026)] and IL-6 > 40 pg/mL [OR:10.01 (1.66–60.13; 0.012)] were independent predictors of death.

Conclusion
In hospitalized older adults with COVID-19, tomographic pulmonary involvement > 50%, anemia, vitamin D below 40 ng/mL, and CRP above 80 mg/L were independent risk factors for progression to SRF/MV. The presence of chronic atrial fibrillation, previous cancer, IL-6 > 40 pg/mL, and anemia were independent predictors of death.
The application research of AI image recognition and processing technology in the early diagnosis of the COVID-19
Authors: Chen Wenyu , Yao Ming , Zhu Zhenyu , Sun Yanbao , Han Xiuping 
Published: February 2022

Abstract
Background
This study intends to establish a combined prediction model that integrates the clinical symptoms,the lung lesion volume, and the radiomics features of patients with COVID-19, resulting in a new model to predict the severity of COVID-19.

Methods
The clinical data of 386 patients with COVID-19 at several hospitals, as well as images of certain patients during their hospitalization, were collected retrospectively to create a database of patients with COVID-19 pneumonia. The contour of lungs and lesion locations may be retrieved from CT scans using a CT-image-based quantitative discrimination and trend analysis method for COVID-19 and the Mask R-CNN deep neural network model to create 3D data of lung lesions. The quantitative COVID-19 factors were then determined, on which the diagnosis of the development of the patients' symptoms could be established. Then, using an artificial neural network, a prediction model of the severity of COVID-19 was constructed by combining characteristic imaging features on CT slices with clinical factors. ANN neural network was used for training, and tenfold cross-validation was used to verify the prediction model. The diagnostic performance of this model is verified by the receiver operating characteristic (ROC) curve.

Results
CT radiomics features extraction and analysis based on a deep neural network can detect COVID-19 patients with an 86% sensitivity and an 85% specificity. According to the ROC curve, the constructed severity prediction model indicates that the AUC of patients with severe COVID-19 is 0.761, with sensitivity and specificity of 79.1% and 73.1%, respectively.

Conclusions
The combined prediction model for severe COVID-19 pneumonia, which is based on deep learning and integrates clinical aspects, pulmonary lesion volume, and radiomics features of patients, has a remarkable differential ability for predicting the course of disease in COVID-19 patients. This may assist in the early prevention of severe COVID-19 symptoms.
Physical environmental opportunities for active play and physical activity level in preschoolers: a multicriteria analysis
Authors: Nobre Juliana Nogueira Pontes , Morais Rosane Luzia De Souza , Prat Bernat Viñola , Fernandes Amanda Cristina , Viegas Ângela Alves , Figueiredo Pedro Henrique Scheidt , Costa Henrique Silveira , Camargos Ana Cristina Resende , de Alcantara Marcus Alessandro , Mendonça Vanessa Amaral , Lacerda Ana Cristina Rodrigues 
Published: February 2022

Abstract
Background
Active play opportunities seems to influence the level of physical activity during childhood. However, a gap remains about which environmental opportunities including the daycare physical environment could have a positive impact on the level of physical activity in preschoolers.

Objectives
(1) To develop an index to measure the environmental opportunities of free active play for preschoolers of middle-income countries; (2) to check the relationship and contribution of the index to explain objectively the level of physical activity.

Methods
A quantitative, cross-sectional, exploratory study with 51 preschool children. The established criteria for the index according to the literature were: (1) Outdoor time on typical days of the week. (2) Outdoor time on a typical weekend day. (3) The presence of internal space and external environment in the child’s home that allows playing. (4) Presence of patio with space for games at the school. (5) Presence of a playground with a toy at the school. We applied multi-attribute utility theory for the determination of the multicriteria index of physical environmental opportunities. Pearson’s correlation analysis and simple linear regression were used to verify the association between the index and the physical activity level.

Results
The index showed a positive correlation with the level of physical activity, e.g., the average time of MVPA (r = 0.408, p = 0.003). The univariate linear regression demonstrated that the quality of physical environmental opportunities for physical activity explained 20% of the preschooler’s classification as active and 16% of the time in moderate to vigorous physical activity (p < 0.001).

Conclusion
Physical environmental opportunities for active play have a positive effect on physical activity in preschoolers and should be encouraged in different social segments.
The relationship between peak inspiratory flow and hand grip strength measurement in men with mild chronic obstructive pulmonary disease
Authors: Tsuburai Takahiro , Komase Yuko , Tsuruoka Hajime , Oyama Baku , Muraoka Hiromi , Hida Naoya , Kobayashi Takayuki , Matsushima Shinya 
Published: February 2022

Abstract
Background
Chronic obstructive pulmonary disease (COPD) decreases quality of life and muscular strength. Inspiratory flow is important for inhalants in the bronchi but is complicated to measure in routine practice. We hypothesized that hand grip strength (HGS) would correlate with inhalation rate in patients with mild COPD.

Methods
The COPD patients were recruited at the St. Marianna University School of Medicine, Yokohama Seibu Hospital, from 2015 to 2018. We measured peak inspiratory flow (PIF) through an In-Check flow meter attached with Diskus [PIF(D)] and Turbuhaler [PIF(T)] inhalers. The 6-min walking test (6MWT), and the fraction of exhaled nitric oxide (FENO), spirometry, HGS, or forced oscillation technique (FOT) parameters were measured.

Results
Forty-four subjects were enrolled. All were men, with a mean age (± SD) of 77.8 ± 9.36 years. Thirty-nine patients had mild COPD. PIF(D) was 110 (80, 140) L/min (median, interquartile range), PIF(T) was 80 (70, 90) L/min, and HGS was 28.7 (13.8, 43.6) kgf. PIF(D) and PIF(T) were significantly correlated (r = 0.443, p = 0.003). PIF(D) was significantly correlated with age (r = − 0.327, p = 0.030) and HGS (r = 0.326, p = 0.031). PIF(T) was significantly correlated with age (r = − 0.328, p = 0.030), FVC (r = 0.351, p = 0.019), 6MWT distance (r = 0.392, p = 0.011), and HGS (r = 0.328, p = 0.030).

Conclusion
HGS might be more useful for predicting PIF than other parameters. Also, elderly COPD patients need to be taught inhaled methods carefully.