bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical and genetic associations of the CLOCK circadian rhythm gene and depressive disorders in patients with alcohol dependence syndrome during the period of alcohol abstinence
Authors: Tulbaeva N. R. , Nasyrova R. F. , Smirnova D. A. , Ashurov Z. Sh. , Efremov I. S. , Dobrodeeva V. S. , Abdrakhmanova A. E. , Asadullin A. R. 
Published: October 2022

About 20% of patients with depression are diagnosed with alcohol dependence, and alcohol dependent individuals are at a higher risk of developing depression. A number of authors point to the relationship of CLOCK gene activity with both affective disorders and alcohol use/dependence disorders; in particular, variations in the CLOCK gene at the evidence level link to depression and stress.Objective: to establish clinical and genetic associations of the CLOCK circadian rhythm gene and depressive disorders during the period of abstinence in patients with alcohol dependence syndrome.Patients and methods. From June 2019 to December 2022, 402 patients (mean age 42.47±7.5 years) were examined, who underwent outpatient follow-up at a narcological dispensary not earlier than 1 month after and not later than 2 months after discharge from the hospital. All patients were diagnosed with middle-stage alcohol dependence syndrome, early remission phase. Depending on the presence of an episode of depression at the time of the examination, the main group (patients with a depressive disorder; n=128) and a comparison group (patients without a depressive disorder; n=274) were formed. Clinical interviews and psychometric study using the Montgomery–Asberg Depression Scale, were conducted for all the subjects. All subjects provided 10 ml venous blood samples for molecular, genetic and biochemical studies.Results and discussion. Correlations were found between the carriage of the TT genotype of the CLOCK gene in patients with alcohol dependence and concomitant clinical depression. Carrying the TT genotype of the CLOCK gene is presumably associated with the predominance of the following symptoms of depression, which demonstrated statistically significant differences: loss of appetite, impaired concentration, apathy, as well as with a higher overall score on the MADRS depression scale. The established association between the CLOCK gene and depression in people with alcohol dependence can be considered as a vulnerability factor in relation to the development of depression in patients with the underlying disease – alcohol dependence syndrome.Conclusion. The CLOCK gene is associated with the development of depression in patients suffering from alcohol dependence. Carriers of the TT genotype of the CLOCK gene (rs1801260) to a greater extent than carriers of other genotypes are characterized by the development of comorbid depression, as well as the predominance of such clinical symptoms as loss of appetite, impaired concentration, apathy, and a higher overall score on the MADRS depression scale.
The relationship between dissociative experiences and childhood trauma in nursing and midwifery students
Authors: Arabpour F. F. , Amini Sh. , Bidaki R. , Ashtari R. , Sepehri F. , Moghadam Ahmadi A. , Bakhshi H. , Bozorg B. 
Published: October 2022

Objective: dissociative disorders usually have a poor prognosis. Childhood trauma is one of the most important predisposing factors for it. This study aimed to investigate the relationship between dissociative experiences with childhood abuse, in nursing and midwifery students of Rafsanjan University Medical Science.Patients and methods. This cross-sectional study was carried out in nursing and midwifery students of Rafsanjan University of Medical Sciences. The students were asked to complete Dissociative Experience (DES) and Traumatic Life Events Questionnaires. Descriptive statistics, independent t-test, ANOVA, chi-square test and pearson correlation coefficient were used for statistical analysis.Results and discussion. The prevalence of moderate and severe dissociative experiences among the participated students was about 38%. Nearly 50% of the students reported to have moderate to severe childhood injuries. Significantly higher dissociative experiences scores were observed in men compare with women (P=0.015). Moderate correlations were detected between subscales of childhood traumatic life events questionnaire and dissociative experiences score (P<0.05). Conclusion. The prevalence of dissociative experiences among the studied students was moderately high which revealed the necessity and importance of psychological counseling among health professional students. A positive correlation was detected between dissociative disorders and traumatic events. Therefore, in order to reduce the chance of dissociative disorder, childhood psychological counseling is necessary in children who have had traumatic events. Keywords: dissociative disorders, adult survivors of child adverse events, nursing, midwifery>˂ 0.05).Conclusion. The prevalence of dissociative experiences among the studied students was moderately high which revealed the necessity and importance of psychological counseling among health professional students. A positive correlation was detected between dissociative disorders and traumatic events. Therefore, in order to reduce the chance of dissociative disorder, childhood psychological counseling is necessary in children who have had traumatic events.
Well-Developed Coronary Collateral Circulation Is Associated With Higher Thrombus Burden in the Setting of ST-Segment Elevation Myocardial Infarction
Authors: Vural Aslı , Kurt Devrim , Karagöz Ahmet , Günaydın Zeki Yüksel 
Published: October 2022

Background
This study investigated the relationship between coronary collateral circulation (CCC) and intracoronary thrombus burden in patients undergoing primary percutaneous coronary intervention for ST-segment elevation myocardial infarction (STEMI). CCC and thrombus burden are predictive of clinical outcomes in patients with STEMI.

Methods
Patients with STEMI undergoing primary percutaneous coronary intervention were enrolled (n = 172). CCC was graded according to the Cohen–Rentrop classification. Patients were classified as insufficient (grade 0 or 1, n = 134) or well-developed (grade 2 or 3; n = 38) CCC. The Thrombolysis in Myocardial Infarction scale was used to evaluate intra-coronary thrombus burden. The low-thrombus-burden group comprised those with grades 0 to 2, and the high-thrombus-burden group comprised those with grades 3 or 4.

Results
Right coronary artery infarcts had a 13.830-fold higher chance of having well-developed CCC than did left anterior descending artery infarcts (P < .001). Circumflex artery infarcts had a 7.904-fold higher chance of well-developed CCC than did left anterior descending artery infarcts (P = .016). High thrombus burden was associated with a 4.393-fold higher chance for well-developed CCC than was low thrombus burden (P = .030). Low albumin levels were related to a greater chance of having well-developed CCC (P = .046).

Conclusion
Patients with well-developed CCC have higher thrombus burden than do those with insufficient CCC. Because well-developed CCC is an indicator of more severe underlying lesions, we speculate that patients with severe lesions are more prone to experience more complicated STEMI with high thrombus burden.
Energiegerechtigkeit im Windenergieausbau – Finanzielle Teilhabe als Möglichkeit zur Stärkung lokaler Akzeptanz?
Authors: Olbrich Sarah , Fünfgeld Hartmut 
Published: October 2022

Onshore wind energy development is often delayed or even prevented by local resistance. Against this backdrop, we discuss financial participation as a measure to promote local acceptance by positively influencing the perceived experience of justice. Building on the concept of energy justice, this paper investigates the extent to which different forms of financial participation are suitable for better distributing costs and benefits, creating opportunities for participation, and examining who can participate financially. In addition to a comprehensive literature review, interviews were conducted with wind turbine planners and operators. These show that stakeholders engage in financial participation to different degrees across different projects and that the preferred form of participation varies from one region to another. Moreover, no model of financial participation appears to be suited to address all dimensions of energy justice, as all models are characterised by certain advantages and disadvantages. Therefore, the availability of financial participation options alone is unlikely to increase local acceptance. Such options can, however, be effective when combined with other measures to increase acceptance.
Perbandingan Kosa Kata Bahasa Melayu Patani (Thailand) antara Dialek Yala dan Menara dalam Ranah Masyarakat
Authors: Kengmalaphi Nur Laila , Muallimin Muallimin 
Published: October 2022

Pada bahasa Melayu Patani (Thailand) terdapat dialek Yala dan Menara. Kedua dialek tersebut digunakan dalam ranah masyarakat Patani. Penelitian ini mengkaji perbedaan antara kedua dialek tersebut, khususnya dalam hal kosakata dengan pendekatan deskriptif kualitatif. Data penelitian berupa percakapan yang digunakan oleh masyarakat Patani, baik dialek Yala maupun dialek Menara. Ada terdapat 45 kosa kata yang dibandingkan antara dialek Yala dan Menara. Selain kata, ada 8 frasa yang dibandingkan antara Dialek Yala dan Dialek Menara. Berdasarkan temuan penelitian masyarakat patani merupakan masyarakat yang memiliki bahasa yang unik dalam komunikasi, yaitu pertama, bahasa Melayu Patani dialeknya berbeda dengan bahasa Melayu lainnya. Ciri kedua yaitu bahwa dalam bahasa Melayu Patani banyak menyingkatkan kalimat seperti "Nak gi mana" untuk pertanyaan 'Hendak pergi kemana ?". Yang ketiga, Bahasa Melayu merupakan linguafranca, bahasa yang diguankan oleh masyarakat Melayu dan Thai, berupa campur kode antara bahasa Melayu dengan bahsa Thai.Wilayah Yala dan Pattani masih tergolong dalam dialek yang sama karena kedua wilayah tersebut mempunyai jarak yang sangat dekat dan memiliki variasi dan latar belakang yang sama. Sementara itu, Dialek Menara lebih dekat dengan bahasa Melayu standar karena secara geografis lebih dekat bahasa yang digunakan di Malaysia.
Dinamika Dimensi Budaya Kerajinan Ukir Jepara : Dari Seni Hias Dinding Masjid Mantingan Menuju Pasar Internasional
Authors: Indrahti Sri 
Published: October 2022

Artikel ini mendiskripsikan tetang proses masuknya pemodal asing serta pengaruh yang ditimbulkan dalam pengelolaan industri kerjainan ukir di Jepara (1980-2010). Tujuan dari penelitian ini adalah; mengidentifikasi masalah-masalah yang dihadapi industri kerajinan ukir dalam menghadapi pemodal asing di Jepara, menemukan dan mendiskripsikan secara menyeluruh reaksi yang muncul, menemukan dan menganalisis interaksi sosial budaya orang asing dan orang pribumi, menemukan dan menganalisis proses datang-perginya pemodal asing, pengaruh yang ditimbulkan bagi keberlangsungan industri kerajinan ukir. Penelitian ini menggunakan data primer dan data sekunder. Data primer, antara lain arsip yang tersimpan di Dinarpus Jepara maupun Semarang, Dinas Perdagangan dan perindustrian Jepara tentang PMA dan PMDN, serta unit usaha kerajinan ukir. Data sekunder antara lain majalah bulanan Gema Bumi Kartini bulanan terbitan Pemkab Jepara, jurnal, hasil penelitian yang relevan dengan industri kerajinan ukir Jepara pada periode penulisan. Fakta di lapangan akan dilengkapi dengan wawancara informan pelaku, pengambil kebijakan serta komunitas yang mempunyai kepedulian pada sektor keberlangsungan industri kerajinan ukir. Tahap terakhir adalah historiografi dengan merekonstruksi berdasarkan data yang diperoleh melalui proses pengujian dan analisis kritis, untuk menyajikan informasi baru tentang pemodal asing di Jepara dalm industri kerajinan ukir.
Proenkephalin A as a marker for glomerular filtration rate in critically ill children: validation against gold standard iohexol GFR measurements
Authors: Smeets Nori J.L. , Hartmann Oliver , Schulte Janin , Schreuder Michiel F. , de Wildt Saskia N. 
Published: October 2022

Abstract

Objectives
Accurate determination of glomerular filtration rate (GFR) is important. Several endogenous biomarkers exist for estimating GFR, yet, they have limited accuracy, especially in the paediatric population. Proenkephalin A 119–159 (PENK) is a novel and promising GFR marker, but its relation with age in children remains unknown. Also, the value of PENK has never been validated against measured GFR (mGFR) in children when compared to traditional GFR markers including serum creatinine (SCr), SCr-based estimated GFR (eGFR) and cystatin C (cysC).

Methods
Critically ill children and term-born neonates were included in this single-centre, prospective study. Iohexol-based mGFR, SCr, and cysC were determined in each patient. eGFR was calculated using the bedside Schwartz equation, incorporating SCr and height. Spearman correlation coefficients were calculated to determine the correlation between mGFR and PENK, SCr, cysC and eGFR.

Results
For 97 patients (56 children and 41 neonates), mGFR, SCr, cysC and PENK levels were available. PENK levels were higher in young children and decreased to adult PENK reference values around two years of age. PENK levels were highly correlated with mGFR (ρ=−0.88, p<0.001), and similar to mGFR–eGFR correlation (ρ=−0.87, p<0.001). For cysC and SCr the correlation with mGFR was lower (ρ=−0.77 and ρ=−0.46, respectively. Both p<0.001).

Conclusions
The correlation of PENK with mGFR was as good as SCr-based eGFR-mGFR correlation. To determine the added value of PENK in paediatric clinical care and prior to implementation, PENK reference values are needed and the development and validation of a paediatric PENK-based eGFR equation is necessary.
Fractal analysis of structural characteristics and prospecting of the Luanchuan polymetallic mining district, China
Authors: Cui Zhongliang , Huang Eugene , Liu Guanghua , Chen Hao , Guo Xinyu 
Published: October 2022

Abstract
The Luanchuan polymetallic mining district (LPMD) covers many major deposits of the East Qinling metallogenic belt in Henan Province, central China. It has attracted much attention because of its various types of minerals, abundant mineral reserves and huge metallogenic potential. Systematic research on the geology of LPMD has been carried out previously, and it is concluded that the formation of the ore deposits is dominantly controlled by fault structure. However, there are few reports on the quantitative characterization of fault structure and spatial distribution of deposits and the coupling relationship between them. This study applies fractal theory to the illustration of the characteristics of inter-relationship between fault structure and spatial distribution of the ore deposits in LPMD, which then may serve as a basis for further ore exploration. Our results indicate that the capacity dimension (CPDs) of integrated fault structure, NW-trend fault and NE-trend fault for the area investigated are 1.7206, 1.6539 and 1.2145, respectively; while the information dimension (IND) of which is 1.7143, 1.6559 and 1.2222, respectively. The studied area has superior geological environment for potential ore deposits, with major contribution from the NW-trend fault. Spatial distribution dimension value of metallic ore is 0.8873. Quantity fractal dimension and Density fractal dimension values of the metallic deposits are 1.1154 and 1.115, respectively. Quantitatively, the main ore deposits discovered in this area mainly fall on either CPD ≥ 1.49, IND ≥ 1.38 or 1.49 > CPD ≥ 1.00, 1.38 > IND ≥ 1.00. Qualitatively, conditions that facilitate ore deposits require higher fractal dimension values. Among the areas studied, we found that Rank I area is the most ideal region that fulfilled the quantitative and qualitative conditions, which is consistent with the actual location of the ore deposits discovered.
Characterization of Lie-type higher derivations of triangular rings
Authors: Ashraf Mohammad , Ansari Mohammad Afajal , Akhter Md Shamim 
Published: October 2022

Abstract
Let

𝔄

{\mathfrak{A}}

be a triangular ring and let

p
n

⁢

(

U
1

,

U
2

,
…
,

U
n

)

{p_{n}(U_{1},U_{2},\dots,U_{n})}

denote the

(

n
-
1

)

{(n-1)}

th commutator of elements

U
1

,

U
2

,
…
,

U
n

∈
𝔄

{U_{1},U_{2},\dots,U_{n}\in\mathfrak{A}}

.
Suppose that

ℕ

{\mathbb{N}}

is the set of nonnegative integers and

𝔏
=

{

ξ
r

}

r
∈
ℕ

{\mathfrak{L}=\{{\xi_{r}}\}_{r\in\mathbb{N}}}

is
a sequence of additive mappings on

𝔄

{\mathfrak{A}}

such that

ξ
0

=

i
⁢

d
𝔄

{\xi_{0}=id_{\mathfrak{A}}}

, the identity mapping
on

𝔄

{\mathfrak{A}}

, and for each

r
∈
ℕ

{r\in\mathbb{N}}

,

ξ
r

⁢

(

p
n

⁢

(

U
1

,

U
2

,
…
,

U
n

)

)

=

∑

i
1

+

i
2

+
⋯
+

i
n

=
r

p
n

⁢

(

ξ

i
1

⁢

(

U
1

)

,

ξ

i
2

⁢

(

U
2

)

,
…
,

ξ

i
n

⁢

(

U
n

)

)

{\xi_{r}(p_{n}(U_{1},U_{2},\dots,U_{n}))=\sum_{i_{1}+i_{2}+\cdots+i_{n}=r}p_{n%
}(\xi_{i_{1}}(U_{1}),\xi_{i_{2}}(U_{2}),\dots,\xi_{i_{n}}(U_{n}))}

for all

U
1

,

U
2

,
…
,

U
n

∈
𝔄

{U_{1},U_{2},\dots,U_{n}\in\mathfrak{A}}

with

U
1

⁢

U
2

⁢
⋯
⁢

U
n

=
0

{U_{1}U_{2}\cdots U_{n}=0}

.
In this paper, it is shown that under certain conditions

𝔏
=

{

ξ
r

}

r
∈
ℕ

{\mathfrak{L}=\{{\xi_{r}}\}_{r\in\mathbb{N}}}

has the standard form, that is, there exist a higher derivation

{

d
r

}

r
∈
ℕ

{\{{d_{r}}\}_{r\in\mathbb{N}}}

on

𝔄

{\mathfrak{A}}

and a family

{

h
r

}

r
∈
ℕ

{\{{\mathrm{h}_{r}}\}_{r\in\mathbb{N}}}

of additive mappings

h
r

:

𝔄
→

𝒵
⁢

(
𝔄
)

{h_{r}:\mathfrak{A}\rightarrow\mathcal{Z}(\mathfrak{A})}

satisfying

h
r

⁢

(

p
n

⁢

(

U
1

,

U
2

,
…
,

U
n

)

)

=
0

{h_{r}(p_{n}(U_{1},U_{2},\dots,U_{n}))=0}

for all

U
1

,

U
2

,
…
,

U
n

∈
𝔄

{U_{1},U_{2},\dots,U_{n}\in\mathfrak{A}}

with

U
1

⁢

U
2

⁢
⋯
⁢

U
n

=
0

{U_{1}U_{2}\cdots U_{n}=0}

such that
for each

r
∈
ℕ

{r\in\mathbb{N}}

,

ξ
r

⁢

(
U
)

=

d
r

⁢

(
U
)

+

h
r

⁢

(
U
)

{\xi_{r}(U)=d_{r}(U)+h_{r}(U)}

for all

U
∈
𝔄

{U\in\mathfrak{A}}

.
Approximate controllability results in α-norm for some partial functional integrodifferential equations with nonlocal initial conditions in Banach spaces
Authors: Ndambomve Patrice , Kpoumie Moussa El-Khalil , Ezzinbi Khalil 
Published: October 2022

Abstract
In this work, we discuss the approximate controllability of some nonlinear partial functional integrodifferential equations with nonlocal initial condition
in Hilbert spaces. We assume that the corresponding linear part is approximately controllable. The results are obtained by using fractional power theory and α-norm, the measure of noncompactness and the Mönch fixed-point theorem, and the theory of analytic resolvent operators for integral equations. As a result, we obtain a generalization of the work of Mahmudov
[N. I. Mahmudov,
Approximate controllability of evolution systems with nonlocal conditions,
Nonlinear Anal. 68 2008, 3, 536–546],
without assuming the compactness of the resolvent operator. Our results extend and complement many other important results in the literature. Finally, a concrete example is given to illustrate the application of the main results.
Remarks on the Belitskii–Lyubich and discrete Markus–Yamabe conjectures
Authors: Sart Frédéric 
Published: October 2022

Abstract
In this paper we prove the Belitskii–Lyubich conjecture for triangular and gradient mappings. These results resemble those obtained for the discrete Markus–Yamabe conjecture. However, the proofs are quite different, which sheds new light on the subject. We complete the picture by showing that the general versions of the two conjectures can be turned into theorems at little cost, simply by relaxing their spectral condition.
Identification of a novel necroptosis-associated miRNA signature for predicting the prognosis in head and neck squamous cell carcinoma
Authors: Guan Jiezhong , Liu Xinyu , Wang Kang , Jia Yiqun , Yang Bo 
Published: October 2022

Abstract
Head and neck squamous cell carcinoma (HNSCC) is one of the most aggressive malignancies that have a poor prognosis. Necroptosis has been demonstrated in recent years to be a form of inflammatory cell death occurring in multicellular organism, which plays complex roles in cancer. However, the expression of necroptosis-related miRNAs and genes in HNSCC and their correlations with prognosis remain unclear. In this study, R software was used to screen differentially expressed miRNAs downloaded from The Cancer Genome Atlas. A prognostic model containing six necroptosis-related miRNAs (miR-141-3p, miR-148a-3p, miR-331-3p, miR-543, miR-425-5p, and miR-7-5p) was generated, whose risk score was validated as an independent prognostic factor for HNSCC. Target genes of the key miRNAs were obtained from TargetScan, miRDB, and miRTarBase, and 193 genes in the intersection of the three databases were defined as consensus genes. Kyoto Encyclopedia of Genes and Genomes and Gene Ontology analyses indicated that the composition of the tumor microenvironment as well as specific pathways may be closely related to necroptosis in HNSCC. Nine key genes were also obtained by the MCODE and cytoHubba plug-ins of Cytoscape: PIK3CD, NRAS, PTK2, IRS2, IRS1, PARP1, KLF4, SMAD2, and DNMT1. A prognostic model formed by the key gene was also established, which can efficiently predict the overall survival of HNSCC patients. In conclusion, necroptosis-related miRNAs and genes play important roles in tumor development and metastasis and can be used to predict the prognosis of HNSCC.
Mechanisms and influential variables on the abrasion resistance hydraulic concrete
Authors: Guo Jinjun , Gao Minghao , Wang Kun , Zhang Peng 
Published: October 2022

Abstract
Abrasion damage is inevitable for hydraulic structure concrete, to increase the service life of large water conservancies and to keep them running safely and reliably, hydraulic concrete requires a high abrasion resistance. This review synthesizes current practices defined by scientific literature in a format focused on allowing quick comparison and understanding of the current scenario of anti-abrasion concrete enhancing mechanism, measuring methods, and approaches to enhance concrete abrasion resistance. Besides, the review highlights the application of widely used materials and potential materials application, like silica fume and fibers which are mature research at present, and effective but preliminary used materials like nanoparticles, to better understand the development of higher abrasion resistance of concrete. According to the present research, it indicate that incorporating enhancement materials into concrete to achieve better abrasion resistance are basically through the way of hardening cement paste, controlling internal crack propagation, or using stronger coarse aggregate to enhance its ability for anti-abrasive. Finally, based on the systematic literature review, a discussion on major areas holding the significant potential to improve current practices is presented and practical recommendations are provided to advance toward more direct and optimized methods.