bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cost-effectiveness of a structured medication review approach for multimorbid older adults: Within-trial analysis of the OPERAM study
Authors: Salari Paola , O’Mahony Cian , Henrard Séverine , Welsing Paco , Bhadhuri Arjun , Schur Nadine , Roumet Marie , Beglinger Shanthi , Beck Thomas , Jungo Katharina Tabea , Byrne Stephen , Hossmann Stefanie , Knol Wilma , O’Mahony Denis , Spinewine Anne , Rodondi Nicolas , Schwenkglenks Matthias 
Published: April 2022

BackgroundInappropriate polypharmacy has been linked with adverse outcomes in older, multimorbid adults. OPERAM is a European cluster-randomized trial aimed at testing the effect of a structured pharmacotherapy optimization intervention on preventable drug-related hospital admissions in multimorbid adults with polypharmacy aged 70 years or older. Clinical results of the trial showed a pattern of reduced drug-related hospital admissions, but without statistical significance. In this study we assessed the cost-effectiveness of the pharmacotherapy optimisation intervention.MethodsWe performed a pre-planned within-trial cost-effectiveness analysis (CEA) of the OPERAM intervention, from a healthcare system perspective. All data were collected within the trial apart from unit costs. QALYs were computed by applying the crosswalk German valuation algorithm to EQ-5D-5L-based quality of life data. Considering the clustered structure of the data and between-country heterogeneity, we applied Generalized Structural Equation Models (GSEMs) on a multiple imputed sample to estimate costs and QALYs. We also performed analyses by country and subgroup analyses by patient and morbidity characteristics.ResultsTrial-wide, the intervention was numerically dominant, with a potential cost-saving of CHF 3’588 (95% confidence interval (CI): -7’716; 540) and gain of 0.025 QALYs (CI: -0.002; 0.052) per patient. Robustness analyses confirmed the validity of the GSEM model. Subgroup analyses suggested stronger effects in people at higher risk.ConclusionWe observed a pattern towards dominance, potentially resulting from an accumulation of multiple small positive intervention effects. Our methodological approaches may inform other CEAs of multi-country, cluster-randomized trials facing presence of missing values and heterogeneity between centres/countries.
The impact of the modified schedules of anatomy education on students’ performance and satisfaction: Responding to COVID-19 pandemic in South Korea
Authors: Yun Young Hyun , Jo Dong Hyun , Jeon Su Kyoung , Kwon Hyeok Yi , Jeon Yu Mi , Shin Dong Hoon , Choi Hyung Jin 
Published: April 2022

BackgroundThe coronavirus disease 2019 (COVID-19) pandemic substantially undermined medical education and healthcare systems. Owing to the pandemic in South Korea, most medical schools needed to be flexible when conducting online and offline classes, but the guidelines did not reflect the specificity of medical schools. This study described the impact of modified anatomy education schedules at the Seoul National University College of Medicine (SNUCM) on students’ academic performance and satisfaction.MethodsAnatomy education in SNUCM is divided into three regional units (the upper and lower limbs, trunk, and head and neck). Owing to the COVID-19 pandemic, the schedule was mixed with simultaneous and rotating schedules. The authors conducted exceptions for online lectures, cadaver dissections, and written and practical examinations in three classes of approximately 50 students each. Furthermore, the authors assessed students’ performance using three sets of written and practical examinations, and students completed a questionnaire regarding modified anatomy laboratory schedules.ResultsDespite the pandemic events in Seoul and South Korea during the laboratory sessions, all sessions were completed without any confirmed COVID-19 cases among the students, faculty, and staff. Most of the scores on the written and practical examinations significantly decreased in 2020 compared to those in 2019. However, in the trunk session that used the virtual anatomy application, the score on the practical examination in 2020 was significantly higher than that in 2019. Over 70% (79 and 77 out of 105 respondents on the upper and lower limbs and trunk, respectively) and 53% (55/105) students reported that there were no significant difficulties in studying anatomy in a face-to-face laboratory.ConclusionsIn conclusion, an adequate education program for cadaver dissection should be developed and provided to overcome the pandemic restrictions. The study findings could serve as a reference for anatomy education during the COVID-19 pandemic.
Thrombus characteristics evaluated by acute optical coherence tomography in ST elevation myocardial Infarction
Authors: Eriksen Erlend , Herstad Jon , Pertiwi Kartika Ratna , Tuseth Vegard , Nordrehaug Jan Erik , Bleie Øyvind , van der Wal Allard C. 
Published: April 2022

Aims
ST elevation myocardial infarction (STEMI) is caused by an occlusive thrombosis of a coronary artery. We wanted to assess if the thrombus can be characterized according to erythrocyte content and age using intravascular optical coherence tomography (OCT) in a clinical setting.

Methods and results
We performed manual thrombus aspiration in 66 STEMI patients. OCT was done of the thrombus remnants after aspiration. A light intensity ratio was measured through the thrombus. Forty two of the aspirates had thrombus which could be analyzed histomorphologically for analysis of erythrocyte and platelet content, and to determine the age of thrombus as fresh, lytic or organized. There were 11 red, 21 white and 10 mixed thrombi. Furthermore, 36 aspirates had elements of fresh, 7 of lytic and 8 of organized thrombi. There was no correlation between colour and age. OCT appearance could not predict erythrocyte or platelet content. The light intensity ratios were not significantly different in fresh, lytic or organized thrombi.

Conclusion
OCT could not differentiate between red and white thrombi, nor determine thrombus age.
A Multifunctional Adaptive and Interactive AI system to support people living with stroke, acquired brain or spinal cord injuries: A study protocol
Authors: Ottoboni Giovanni , La Porta Fabio , Piperno Roberto , Chattat Rabih , Bosco Annalisa , Fattori Patrizia , Tessari Alessia 
Published: April 2022

Background
Acquired brain injury and spinal cord injury are leading causes of severe motor disabilities impacting a person’s autonomy and social life. Enhancing neurological recovery driven by neurogenesis and neuronal plasticity could represent future solutions; however, at present, recovery of activities employing assistive technologies integrating artificial intelligence is worthy of examining. MAIA (Multifunctional, adaptive, and interactive AI system for Acting in multiple contexts) is a human-centered AI aiming to allow end-users to control assistive devices naturally and efficiently by using continuous bidirectional exchanges among multiple sensorimotor information.

Methods
Aimed at exploring the acceptability of MAIA, semi-structured interviews (both individual interviews and focus groups) are used to prompt possible end-users (both patients and caregivers) to express their opinions about expected functionalities, outfits, and the services that MAIA should embed, once developed, to fit end-users needs.

Discussion
End-user indications are expected to interest MAIA technical, health-related, and setting components. Moreover, psycho-social issues are expected to align with the technology acceptance model. In particular, they are likely to involve intrinsic motivational and extrinsic social aspects, aspects concerning the usefulness of the MAIA system, and the related ease to use. At last, we expect individual factors to impact MAIA: gender, fragility levels, psychological aspects involved in the mental representation of body image, personal endurance, and tolerance toward AT-related burden might be the aspects end-users rise in evaluating the MAIA project.
Association between GnRH analogue use and atopic diseases in patients with prostate cancer: A population-based retrospective cohort study
Authors: Lin Sheng-Feng , Lin Hsiu-Chen , Lee Mei-Yu , Keller Joseph Jordan , Wang Li-Hsuan 
Published: April 2022

Purpose
Gonadotropin-releasing hormone (GnRH) analogues reduce testosterone levels to castration levels in patients with prostate cancer. However, the role of testosterone in atopic diseases has remained undefined. We aimed to investigate this role.

Materials and methods
This retrospective cohort study was conducted using the National Health Insurance Research Database (NHIRD). Patients with prostate cancer were categorized into two groups according to whether they received GnRH analogue treatment (study group I) or not (study group II), and men without prostate cancer and with no GnRH analogue use were defined to comprise the comparison group after their ages and index years were matched with group II. Cox proportional hazard models were used to assess the hazard ratio (HR) of atopic diseases.

Results
Group I, group II, and the comparison group comprised 663, 2,172, and 8,688 individuals, respectively. Group I had a significantly lower risk of atopic diseases (adjusted HR: 0.66, 95% CI, 0.49–0.89, p < 0.01) than did group II. A reduced risk of atopic diseases was found when GnRH analogues were prescribed for 2 months (adjusted HR 0.53, 95% CI, 0.29–0.97, p = 0.04) and 2–14 months (adjusted HR 0.66, 95% CI, 0.49–0.89, p = 0.007). No significant difference in the risk of atopic diseases between group II and the comparison group was observed.

Conclusions
A decreased risk of atopic diseases was observed in patients with prostate cancer treated with GnRH analogues. Further studies are warranted to verify the association between testosterone levels and atopic diseases.
Identifying content to improve risk assessment communications within the Risk Profile: Literature reviews and focus groups with expert and non-expert stakeholders
Authors: Ellermann C. , McDowell M. , Schirren C. O. , Lindemann A.-K. , Koch S. , Lohmann M. , Jenny M. A. 
Published: April 2022

Objective
To improve consumer decision making, the results of risk assessments on food, feed, consumer products or chemicals need to be communicated not only to experts but also to non-expert audiences. The present study draws on evidence from literature reviews and focus groups with diverse stakeholders to identify content to integrate into an existing risk assessment communication (Risk Profile).

Methods
A combination of rapid literature reviews and focus groups with experts (risk assessors (n = 15), risk managers (n = 8)), and non-experts (general public (n = 18)) were used to identify content and strategies for including information about risk assessment results in the “Risk Profile” from the German Federal Institute for Risk Assessment. Feedback from initial focus groups was used to develop communication prototypes that informed subsequent feedback rounds in an iterative process. A final prototype was validated in usability tests with experts.

Results
Focus group feedback and suggestions from risk assessors were largely in line with findings from the literature. Risk managers and lay persons offered similar suggestions on how to improve the existing communication of risk assessment results (e.g., including more explanatory detail, reporting probabilities for individual health impairments, and specifying risks for subgroups in additional sections). Risk managers found information about quality of evidence important to communicate, whereas people from the general public found this information less relevant. Participants from lower educational backgrounds had difficulties understanding the purpose of risk assessments. User tests found that the final prototype was appropriate and feasible to implement by risk assessors.

Conclusion
An iterative and evidence-based process was used to develop content to improve the communication of risk assessments to the general public while being feasible to use by risk assessors. Remaining challenges include how to communicate dose-response relationships and standardise quality of evidence ratings across disciplines.
Quantitative analysis of regional distribution of tau pathology with 11C-PBB3-PET in a clinical setting
Authors: Yousefzadeh-Nowshahr Elham , Winter Gordon , Bohn Peter , Kneer Katharina , von Arnim Christine A. F. , Otto Markus , Solbach Christoph , Anderl-Straub Sarah , Polivka Dörte , Fissler Patrick , Strobel Joachim , Kletting Peter , Riepe Matthias W. , Higuchi Makoto , Glatting Gerhard , Ludolph Albert , Beer Ambros J. ,   for the Alzheimer’s Disease Neuroimaging Initiative
Published: April 2022

Purpose
The recent developments of tau-positron emission tomography (tau-PET) enable in vivo assessment of neuropathological tau aggregates. Among the tau-specific tracers, the application of 11C-pyridinyl-butadienyl-benzothiazole 3 (11C-PBB3) in PET shows high sensitivity to Alzheimer disease (AD)-related tau deposition. The current study investigates the regional tau load in patients within the AD continuum, biomarker-negative individuals (BN) and patients with suspected non-AD pathophysiology (SNAP) using 11C-PBB3-PET.

Materials and methods
A total of 23 memory clinic outpatients with recent decline of episodic memory were examined using 11C-PBB3-PET. Pittsburg compound B (11C-PIB) PET was available for 17, 18F-flurodeoxyglucose (18F-FDG) PET for 16, and cerebrospinal fluid (CSF) protein levels for 11 patients. CSF biomarkers were considered abnormal based on Aβ42 (< 600 ng/L) and t-tau (> 450 ng/L). The PET biomarkers were classified as positive or negative using statistical parametric mapping (SPM) analysis and visual assessment. Using the amyloid/tau/neurodegeneration (A/T/N) scheme, patients were grouped as within the AD continuum, SNAP, and BN based on amyloid and neurodegeneration status. The 11C-PBB3 load detected by PET was compared among the groups using both atlas-based and voxel-wise analyses.

Results
Seven patients were identified as within the AD continuum, 10 SNAP and 6 BN. In voxel-wise analysis, significantly higher 11C-PBB3 binding was observed in the AD continuum group compared to the BN patients in the cingulate gyrus, tempo-parieto-occipital junction and frontal lobe. Compared to the SNAP group, patients within the AD continuum had a considerably increased 11C-PBB3 uptake in the posterior cingulate cortex. There was no significant difference between SNAP and BN groups. The atlas-based analysis supported the outcome of the voxel-wise quantification analysis.

Conclusion
Our results suggest that 11C-PBB3-PET can effectively analyze regional tau load and has the potential to differentiate patients in the AD continuum group from the BN and SNAP group.
Performance Drawing: New Practices Since 1945, Maryclare Foá, Jane Grisewood, Birgitta Hosea and Carali McCall (2020)
Authors: Davis Penny 
Published: April 2022

Review of: Performance Drawing: New Practices Since 1945, Maryclare Foá, Jane Grisewood, Birgitta Hosea and Carali McCall (2020)
London, New York and Dublin: Bloomsbury Visual Arts, Bloomsbury Publishing Plc, 264 pp.,
ISBN 978-1-7883-1384-1, h/bk, £85.00
Flgelharmonische – nur isotrop oder auch negativ inotrop?
Authors: Müller Swen 
Published: April 2022

Flügelharmonische – nur isotrop oder auch negativ inoptrop?
Als riesige Rotationsmaschinen erzeugen Windenergieanlagen (WEA) sowohl mäßig laute hörbare Geräusche als auch unhörbare Druckpulse durch die Passage der Flügel vor dem Mast. Die Oberwellen dieser Pulsfolge (Flügelharmonische) fallen zügig zu höheren Frequenzen ab und liegen bei üblichen Setbacks weit unterhalb der Wahrnehmungsschwelle, sind bei Windkraftgegnern aber dennoch sehr beliebt zum Schüren von Ängsten vor angeblichen gesundheitlichen Gefahren. Anhand der öffentlich zugänglichen Daten der letzten Messkampagne der BGR im Sommer 2021 wird gezeigt, dass selbst die Worst-case Immissionen moderner Megawatt-WEAs immer noch sehr deutlich unter der Wahrnehmungsschwelle liegen, insbesondere, wenn man nur die G-gewichtete Summe der isolierten Flügelharmonischen betrachtet.
Die Auswertung zeigt außerdem, dass bei der ungewichteten Summe die Windgeräusche unter 0.2 Hz den Einzahlwert dominieren, bei der gehörrichtigen G-Bewertung hingegen das breitbandige Rauschen oberhalb der Flügelharmonischen. Der Schalldruckpegel nur der isolierten Flügelharmonischen wird von beiden Zahlenwerten deutlich überschätzt.
Ein Vergleich zu alltäglichen Immissionssituationen in verschiedenen Verkehrsmitteln zeigt, dass man in ihnen mindestens 100-facher und bei Tunneldurchfahrten sogar millionenfach stärkerer Infraschallintensität ausgesetzt sein kann – ohne gesundheitliche Folgen.
Piscicultura no estado do Maranhão: perspectivas para aceleração da produção de peixes nativos
Authors: Souza Antonio Carlos Freitas , Guimarães Erick Cristofore , Santos Jadson Pinheiro , Costa Francisca Neide , Viana Diego Carvalho 
Published: April 2022

A aquicultura mundial tem se destacado dentre as cadeias de produção de proteína animal, com rápido crescimento, contribuindo de forma relevante para a geração de emprego e renda, além disso, mesmo com todas as dificuldades encontradas no ano 2020, continuou crescendo em diversas partes do mundo. Objetivou-se com este trabalho apresentar e compilar dados de produção da piscicultura do estado do Maranhão. O trabalho tem caráter exploratório e utiliza o método de pesquisa bibliográfica, quali-quantitativo, por meio de consulta de dados em plataformas oficiais a partir de uma abordagem cronológica da produção da piscicultura que ocorreu de janeiro de 2013 até março de 2021. Essa compilação de dados constata crescimento da piscicultura no estado do Maranhão nos últimos anos frente ao cenário do país. Nos últimos 4 anos, acumulou crescimento de 97,52%, partindo de uma produção de 24.150 toneladas ano de 2016 para 47.700 toneladas em 2020, ganhando posição de destaque na cadeia produtiva nacional. Devido o estado possuir características ambientais adequadas para o desenvolvimento da piscicultura, aliado a expressiva produção de grãos e os recentes incentivos fiscais advindos do governo estadual, torna-o potencial candidato de nos próximos anos se consolidar como grande produtor de pescado de cultivo e assumir posição de destaque na produção de peixes nativos no Brasil.
Childcare, Parental Behavior and Well-Being during Childhood
Authors: Haeck Catherine , Lebihan Laetitia , Lefebvre Pierre , Merrigan Philip 
Published: April 2022

Abstract
In this paper, we study the long-term impacts on parental health and behaviors of a low-fee universal childcare program for children aged zero to five years old. We follow families for more than 10 years after the reform. For families with preschool children, we show that the adverse effects documented in previous studies on maternal depression and parental behaviors persist over time. However, once children enter school, most negative effects of the program on parental mental health and behaviors fade away. Only the negative effect on positive interactions may have persisted over time.
Familiarity and Race Bias: Evidence from a Television Competition (and the Case for More Women Judges?)
Authors: Chong Bruno Z. , Chong Marco Z. 
Published: April 2022

Abstract
While social interaction is claimed to help reduce racial bias, the evidence is mixed. We argue that not only interaction, but familiarity among agents may help reduce race bias. We use new data from MasterChef, a nationally syndicated television competition that cover 10 years. We find that familiarity does not help reduce race bias. When judges are all Caucasian they appear to favor Caucasian contestants and set back minority contestants in the final placements. Interestingly, we find an analogous finding with minority judges. Female judges are the only ones who show no bias.
Importance of cerebrospinal fluid storage conditions for the Alzheimer’s disease diagnostics on an automated platform
Authors: Ferrer Rosa , Zhu Nuole , Arranz Javier , Porcel Inmaculada , El Bounasri Shaimaa , Sánchez Oriol , Torres Soraya , Julve Josep , Lleó Alberto , Blanco-Vaca Francisco , Alcolea Daniel , Tondo Mireia 
Published: April 2022

Abstract

Objectives
Alzheimer’s disease (AD) is considered the most common cause of dementia in older people. Cerebrospinal fluid (CSF) Aβ1-42, Aβ1-40, total Tau (t-Tau), and phospho Tau (p-Tau) are important biomarkers for the diagnosis, however, they are highly dependent on the pre-analytical conditions. Our aim was to investigate the potential influence of different storage conditions on the simultaneous quantification of these biomarkers in a fully-automated platform to accommodate easier pre-analytical conditions for laboratories.

Methods
CSF samples were obtained from 11 consecutive patients. Aβ1-42, Aβ1-40, p-Tau, and t-Tau were quantified using the LUMIPULSE G600II automated platform.

Results
Temperature and storage days significantly influenced Aβ1-42 and Aβ1-40 with concentrations decreasing with days spent at 4 °C. The use of the Aβ1-42/Aβ1-40 ratio could partly compensate it. P-Tau and t-Tau were not affected by any of the tested storage conditions. For conditions involving storage at 4 °C, a correction factor of 1.081 can be applied. Diagnostic agreement was almost perfect in all conditions.

Conclusions
Cutoffs calculated in samples stored at −80 °C can be safely used in samples stored at −20 °C for 15–16 days or up to two days at RT and subsequent freezing at −80 °C. For samples stored at 4 °C, cutoffs would require applying a correction factor, allowing to work with the certainty of reaching the same clinical diagnosis.
Influencers as political agents? The potential of an unlikely source to motivate political action
Authors: Naderer Brigitte 
Published: April 2022

Abstract
The impact of social media influencers (SMIs) on brand-related outcomes has been well researched, yet whether this influence also impacts political participation and what role the relationship between SMIs and their audiences play has not been sufficiently examined to date. Basing this study on the Balance Model, I investigated the potential of an unlikely vs. a likely source and the role of similarity with a SMI based on a shared topic interest to elicit the intention for political action in an experimental study (n = 222). The perceived similarity with the SMI was examined as a mediator and the role of the shared topic interest with the SMI as a potential moderator. The results indicate that a likely source for political information generated a greater topic fit. The perceived similarity with the source depended on the shared topic interest between the source and the participants. This is a key finding, as perceived similarity with the source in turn predicted the intention to take political action, which positively activated participants who shared the topic interest of the unlikely source even if they did not indicate a topic interest in politics. Thus, a shared interest with a SMI might make even those not interested in politics more open to political participation.