bluuebunny/crossref_metadata_2025_split huggingface dataset:
Gene-Environment interactions and the case of BMI and obesity: how much do they matter?
Authors: Huangfu Yiyue , Palloni Alberto , Beltrán-Sánchez Hiram , McEniry Mary 
Published: September 2022

Abstract
We investigate the demographic and population health implications of gene-environment interactions (GxE) in the case of BMI and obesity. We seek to answer three questions: (a) what is the first order impact of GxE effects on BMI and obesity, e.g. the direct effect of G in different E? (b) how large is the impact of GxE effects on second-order health outcomes associated with BMI and obesity, such as Type 2 Diabetes (T2D), disability, and mortality ? (c) is the range of available empirical estimates of GxE effects large enough to influence future trajectories of BMI, obesity, T2D, disability, and mortality? To limit the scope of the paper we focus on environments defined by birth cohorts. However, extensions to other environments, including but not limited to education, SES, early conditions, physical settings, are quite straightforward.
Impact of Arterial Stiffness on Echocardiographic Myocardial Work Indices in Patients with Isolated Bicuspid Aortic Valve
Authors: Toprak Cüneyt , Çakır Hakan , Karagöz Ali , Isgandarov Khagani , Biyikli Kadir , Tuncer Şeref Berk , Kargın Ramazan 
Published: September 2022

Abstract
Objective
Data related to the existence of left ventricular (LV) abnormalities in normo-functional bicuspid aortic valve (BAV) disease is scarce. Also, the impact of afterload and the involved mechanisms are unclear. In this work, we study the relationship between LV function assessed with myocardial work index (MWI) and arterial stiffness in a cohort of normo-functioning BAV patients.
Methods
In this study, we included a total of 38 consecutive patients with isolated BAV and 44 age- and gender-matched control subjects with tricuspid aortic valve (TAV). All participants underwent transthoracic echocardiography (TTE) to assess conventional parameters, global longitudinal strain (GLS), and MW by non-invasive left ventricular pressure–strain loop (LV-PSL) method. The aortic pulse wave velocity(PWV) was used to determine arterial stiffnessand wave reflection was evaluated by applanation tonometry.
Results
The mean aortic PWV was significantly higher in BAV patients (6.4 ± 0.80, 7.02 ± .1.2, p = 0.01, respectively). The statistical difference was not significant for the parameters linked to LV-MW, such as global work index (GWI) and global constructive work (GCW) between the BAV and control groups (1969 ± 259 and 2014 ± 278, p = 0.45; 2299 ± 290 and 2359 ± 345, p = 0.39 respectively). In contrast, the BAV and control groups were significantly different in terms of global work efficiency (GWE) (96.26 ± 1.69 and 97.05 ± 1.27, p = 0.02) and global wasted work (GWW) ; (78.2 ± 32.1 and 61.8 ± 24.4, p = 0.01,). Multivariable ordinary least square (OLS) regression analysis for predicting GWW demonstrated that BAV increased GWW (ß=8.4; 95% CI: 1.5–15.3; p = 0.04) and PWV increased GWW (ß=5.6; 95% CI: 0.7–10.5; p = 0.01).
Conclusion
The results of the MW analysis in this study revealed that the GWE values were lower and the GWW values were higher. Also, PWV had a significant impact on MW and it was independently associated with GWW. The association between aortic PWV and GWW may help to explain the documented mechanism of subclinical myocardial dysfunction in isolated BAV patients.
The importance of the diestrus stages (early, middle, late) to the diagnosis of the endometrial disease in the bitch
Authors: Praderio Romina Gisele , Rearte Ramiro , Stornelli María Cecilia , Mitacek María Carla García , Sota Rodolfo Luzbel , Stornelli Maria 
Published: September 2022

Abstract
The endometrium is the uterine layer wherein embryo implantation and development take place. Complete knowledge of the endometrium's normal histology is critical for advancing the diagnosis of subclinical endometrial diseases. Several researchers studied subclinical endometritis (END) in different species but the cause/s remain unknown. Furthermore, simple and reliable diagnostic tools are still necessary to diagnose subclinical END. In the bitch, diestrus has been selected as the stage of the reproductive cycle to perform the diagnosis of END. This work aimed to perform morphometric and cytological studies in bitches with normal endometrium (NE) and END in diestrus' stages. Forty-five mixed-breed clinically healthy bitches, in diestrus, were used in this study. Biopsies and cytology were obtained from uterine horns, processed, and examined using a microscope. Samples from NE and END were selected, images acquired, and software for image analysis was used to measure the endometrial thickness (ET), external glandular diameter (EGD), internal glandular diameter (IGD), glandular density, and glandular cell height (CG). Significant differences were observed in GC height, EGD, IGD, and serum P4 concentrations along diestrus. In END, both EGD and IGD were smaller than NE. The current study showed histomorphometric characteristics that appear to be influenced by P4 concentrations. In our opinion, it is relevant to consider how far the bitch had progressed into diestrus at the moment of the diagnosis of endometrial disease. Data recorded in the present study could be helpful to clarify cases of bitches with unexplained infertility or subfertility.
IL-11 system participates in pulmonary artery remodeling and hypertension in pulmonary fibrosis
Authors: Milara Javier , Roger Inés , Montero Paula , Artigues Enrique , Escrivá Juan , Cortijo Julio 
Published: September 2022

Abstract
Background
Pulmonary hypertension (PH) associated to idiopathic pulmonary fibrosis (IPF) portends a poor prognosis. IL-11 has been implicated in fibrotic diseases, but their role on pulmonary vessels is unknown. Here we analyzed the contribution of IL-11 to PH in patients with IPF and the potential mechanism implicated.
Methods
Pulmonary arteries, lung tissue and serum of control subjects (n = 20), IPF (n = 20) and PH associated to IPF (n = 20) were used to study the expression and localization of IL-11 and IL-11Rα. Two models of IL-11 and bleomycin-induced lung fibrosis associated to PH were used in Tie2-GFP transgenic mice to evaluate the contribution of IL-11 and endothelial cells to pulmonary artery remodeling. The effect of IL-11 and soluble IL-11Rα on human pulmonary artery endothelial cells and smooth muscle cell transformations and proliferation were analyzed.
Results
IL-11 and IL-11Rα were over-expressed in pulmonary arteries and serum of patients with PH associated to IPF vs IPF patients without PH. Recombinant mice (rm)IL-11 induced lung fibrosis and PH in Tie2-GFP mice, activating in vivo EnMT as a contributor of pulmonary artery remodeling and lung fibrosis. Transient transfection of siRNA-IL-11 reduced lung fibrosis and PH in Tie2-GFP bleomycin model. Human (h)rIL-11 and soluble hrIL-11Rα induced endothelial to mesenchymal transition (EnMT) and pulmonary artery smooth muscle cell to myofibroblast-like transformation, cell proliferation and senescence in vitro.
Conclusions
IL-11 and IL-11Rα are overexpressed in pulmonary arteries of PH associated to IPF patients, and contributes to pulmonary artery remodeling and PH.
Genome-wide Transcriptome Analysis Reveals the Gene Regulatory Network in Star Fruit Flower Blooming
Authors: Qin Si , Li Xiao-Ping , Wu Chun-Mei , You Le , Peng Donghui , Ahmad Sagheer , Ren Hui , Liu Zhong-Jian , Zhai Jun-Wen , Wu Sha-Sha 
Published: September 2022

Abstract
The star fruit is a perennial woody fruit tree, which can blossom and bear fruit many times a year. The time and quantity of flowering are the key indicators of its economic value. However, the flowering molecular mechanism of star fruit is still unknown. This study provides a genome-wide analysis of the key flowering genes of star fruit. Based on a previous morphological study of flower bud differentiation, the reproductive buds, vegetative buds and mature leaves of star fruit were sampled for transcriptome analysis. The results showed that the expression of GI, COL4, COL5, FT, FCA, FVE, PIF4, LFY, SVP-like, AP1 and FUL was correlated with floral induction and transition. The expression of TFL1, SVP-like genes (Yangtao2015203 and Yangtao2021074) was correlated with the inhibition of floral transition. Thus, we proposed a putative network of flower blooming in star fruit. This study provides useful information for investigating the genetic mechanism of flowering in star fruit and other perennial woody fruit trees.
Polymer Modified Concrete containing Unsaturated Polyester by different amounts of styrene
Authors: Farokhi Ehsan Hematpouri , Fathi Mojtaba , Amani Ali 
Published: September 2022

Abstract
This article presents an experimental investigation of the mechanical and physical behaviors of Polymer Modified Concrete containing %2.5, 5%, 7.5% and %10 Unsaturated Polyester resin with %30, 37.5% and %45 styrene. Twelve mixtures were designed and compressive strength, splitting tensile strength, water absorption, stress-strain curve, modulus of elasticity, energy absorption capacity, failure crack mode and SEM analysis were examined. The results indicated, by replacing cement with Unsaturated Polyester, the compressive and tensile strengths and the water absorption decreased about %15 to %50, but the strain and the energy absorption were increased significantly up to %110 and %30 respectively. Also, adding the amount of styrene in resin led to increase both the compressive strength and energy absorption capacity up to 25%, but according to SEM images it led the formation of a thick polymeric region with compressed layers in ITZ, cause to decrease in tensile strength and water absorption down to 25%.
C1q/TNF-related protein 9 alleviates atherosclerosis by inhibiting ox-LDL-induced VSMC-derived foam cell necroptosis via the AMPK pathway
Authors: Wang Xuedong , Huang Xingtao , Yang Mengyue , Zhang Lu , Zhang Ruoxi , Du Wenjuan , Hou Jingbo , Liu Qi 
Published: September 2022

Abstract
Necroptosis amplifies inflammation and plays an important role in atherosclerosis progression. However, the role of necroptosis of vascular smooth muscle cell (VSMC)-derived foam cells, the most abundant cells in atherosclerotic lesions, in cellular dysfunction and atherosclerosis remains unknown. In the present study, we evaluated the effect of oxidized low-density lipoprotein (ox-LDL) on VSMC-derived foam cell death and determined the role of VSMC-derived foam cell necroptosis in inflammation. Furthermore, we determined whether and how C1q/TNF-related protein 9 (CTRP9), a cardiovascular protective adipokine, protects against ox-LDL-induced cell dysfunction and atherosclerosis. Our results revealed that low concentration ox-LDL potently induced VSMC-derived foam cell necroptosis and promoted the expression of pro-atherosclerotic factors via an oxidative stress-related mechanism. CTRP9 significantly reversed ox-LDL-induced cell damage and the related dysfunction through the AMPK pathway-mediated expression of antioxidant enzymes. CTRP9 overexpression reduced atherosclerotic lesion size in the aortic sinus and enhanced features of plaque stability. Overall, our findings suggest that CTRP9 is a potential drug target to suppress atherosclerosis and stabilize plaques.
Putative Therapeutic Impact of Inflammasome Inhibitors against
COVID-19-Induced ARDS
Authors: Nabavi Seyed Fazel , Sahebnasagh Adeleh , Shahbazi Ahad , Nabavi Seyed Mohammad , Azimi Saeid , Kashani Malihe Khayat , Habtemariam Solomon , Rahmani Mojde , Badiee Mohadese , Hashemi Javad , Saghafi Fatemeh , Amini Kiumarth , Azimi Mina , Rezabakhsh Aysa 
Published: September 2022

Abstract:
Given the importance of COVID-19-induced ARDS, recently, researchers have
strived to determine underlying mechanisms involved in the inflammatory responses. In
this regard, inflammasomes possess a distinct priority for cytokine storm occurrence and,
subsequently, ARDS progression in ill patients with SARS-CoV-2 infection. In this minireview,
the characteristics of known inflammasome inhibitors and designed research in
this field were concretely deciphered.
Artificial Intelligence in Efficient Diabetes Care
Authors: Khodve Gopal Bhagwan , Banerjee Sugato 
Published: September 2022

Abstract:
Diabetes is a chronic disease that is not easily curable but can be managed efficiently.
Artificial Intelligence is a powerful tool that may help in diabetes prediction, continuous glucose
monitoring, Insulin injection guidance, and other areas of diabetes care. Diabetes, if not appropriately
managed, leads to secondary complications like retinopathy, nephropathy, and neuropathy.
Artificial intelligence helps minimize the risk of these complications through software and Artificial
Intelligence-based devices. Artificial Intelligence can also help physicians in the early diagnosis
and management of diabetes while reducing medical errors. Here we review the advancement
of Artificial Intelligence in diabetes management.
Large-Scale Evaluation of ureC (glmM) and SSA Conventional PCR for Rapid Direct Detection of Helicobacter pylori in Gastric Biopsies as Compared to rpoB-based Quantitative Real-Time PCR
Authors: Akeel Mohammed , Shehata Atef , Elhafey Ahmed , Elmakki Erwa , Aboshouk Thanaa , Ageely Hussein , Mahfouz Mohammed Salih 
Published: September 2022

Background:
Conventional polymerase chain reaction (PCR)-based methods play a major role in the direct detection of H. pylori in clinical specimens, with time-saving as compared to culture-based methods. However, specificity and sensitivity vary among different varieties of these PCRs, which consequently could affect the accuracy of diagnosis of H. pylori infection. The study aimed to evaluate the utility of ureC (glmM) and SSA conventional PCR methods for rapid direct detection of H. pylori by comparing them with rpoB-based quantitative real-time PCR.

Methods:
A total of 402 non-repeated gastric biopsy specimens were subjected to DNA extraction followed by conventional ureC (glmM) and SSA PCR, and rpoB-based quantitative real-time PCR, which was used as the gold standard.

Results:
H. pylori was detected in 119 (29.6%), 126 (31.34%), and 187 (46.5%) of the tested specimens using ureC (glmM) PCR, SSA PCR, and real-time quantitative PCR, respectively. The specificity of the SSA PCR was higher than that of ureC (glmM) PCR (99.5% and 98.6%, respectively). The SSA PCR was more sensitive than the ureC (glmM), (66.8% and 62%, respectively). The diagnostic accuracy of SSA PCR (84.33%) was higher than that of ureC (glmM) PCR (81.59%).

Conclusion:
Overall, SSA PCR is more specific, sensitive, and diagnostically accurate than ureC (glmM) PCR, giving the SSA PCR assay superiority as a simple, rapid, and accurate diagnostic tool for direct detection of H. pylori in gastric tissue specimens.
Structural Insights and Pharmaceutical Relevance of Plumbagin in Parasitic Disorders: A Comprehensive Review
Authors: Singh Amrat Pal , Sharma Alok 
Published: September 2022

Abstract:Recently, natural products have been became the center of attraction for the scientific society and exploration of their biologically abilities is proceeding continuously. In search for novel antiparasitic agents with an objective of protecting humans from parasitic infections, the present work was focused on naphthoquinones possessing antiparasitic activity. Among naphthoquinones, plumbagin is one of the secondary metabolites exhibiting diverse biological properties such as antibacterial, antimalarial, antiinflammatory, insecticidal and antiparasitic. Plumbagin is reported to have antischistosomiasis, anti-haemonchosis, anti-fascioliasis, antiotoacariasis, anti-leishmaniasis, antimalaria, antiallergic and anthelmintic activities. Besides, various methods of extraction of plumbagin from different methods, their effectiveness against different parasites, and the structure-activity relationship reported by different researchers. This work highlight on recent advancements in the phytochemistry of plumbagin, studies associated with various biological activities. The structure-activity relationship studies have also been summarized. To conclude, present review could be beneficial for the scientific community to get better insight into medicinal research of plumbagin and may provide a new horizon for the rational design of plumbagin based compounds.
The emergence and development history of Demak Bintoro Kingdom
Authors: Rokhman M Nur , Yuliana Lia , Zulkarnain Zulkarnain 
Published: September 2022

This research is aimed to find the emergence and development of Demak kingdom. This research used the five stages historical research method according to Kuntowijoyo, which are topic selection, heuristic, verification, interpretation and writing. Kasultanan Demak is the first Islamic kasultanan in Java which was founded by Raden Patah in 1478. Demak area covers Jepara, Semarang, Tegal, Lembang, Jambi, islands among Kalimantan and Sumatera and some areas in Kalimantan islands. The glory era was in Sultan Trenggana administration who ruled from 1521-1546 M. After the death of Sultan Trenggana, there was power seizure in Demak Kingdom. This seizure occured between the Prince of Sekar Seda ing Lepen and Sunan Prawata who was the only son of Sultan Trenggana. Thus, there was murder conducted by Sunan Prawata towards the Prince of Sekar Seda ing Lepen. The son of Prince of Sekar Seda ing Lepen whose name was Arya Panangsang from Jipang avenged his father’s death by murdering Sunan Prawoto. One of dukes who fighted againts Arya Panangsang was Joko Tingkir. He was one of Sultan Trenggono’s son-in-law and ruled in Pajang. Reputedly, Joko Tingkir had purebred line of Majapahit that is Brawijaya V who was expelled by Girindrawardhana and subserved in Demak Kingdom. Keywords: maket, administration, and Islam Mataram
Revitalization of South Sulawesi socio-cultural values relating to democracy in the era of regional autonomy
Authors: Jumadi Jumadi , Nur Rifai , Patahuddin Patahuddin 
Published: September 2022

This research aims to understand the principles of democracy enforcement in the implementation of regional autonomy, to promote and to revitalize the South Sulawesi socio-cultural values relating to the issue of democracy in the era of regional autonomy, the development of the region potency and the diversity of community to achieve regional and national progress. South Sulawesi since the empire era has posessed socio-cultural values that are closely related to the principles of democracy enforcement. The Socio-cultural values are potential for the regional development, especially in the era of regional autonomy. Social values, one of them are embedded in the democracy principles and foundations in South Sulawesi as the legal basis for organizing the kingdom in South Sulawesi: “rusa’ taro datu, ten rusa’ taro ade’, rusa’ taro ade’ ten rusa’ taro anang, rusa’ anang ten rusa’ taro tomaegae”.means that the decision of datu / king can be canceled by ade ' (council) but the decision of ade' can not be canceled by the king / datu, the decision of ade' can be canceled by public figures, but the willingness of public figures can not be canceled by public figures, the willingness of public figures can be canceled by the society, but the willingness of the society can not be canceled by public figures. This means the highest decision belongs to the society. Keywords: Socio-Cultural Values and Democracy in the era of regional Autonomy.
STRENGTHENING SOCIAL CAPITAL IN IMPLEMENTING SEGORO AMARTO MOVEMENT TO ALLEVIATE POVERTY IN YOGYAKARTA CITY
Authors: Satlita Lena , Dewi Utami , Priyanto Anang 
Published: September 2022

This article aims to examine the efforts of stakeholders to strengthen social capital in implementing Segoro Amarto Movement to decrease the number of poverty in Yogyakarta City. The research method of this article was descriptive-qualitative. The data were colected through depth interview, focus group discussion, observation and documentation. The research shows that the implementation of Segoro Amarto Movement Gerakan Segoro Amarto (GSA) had not succeed yet in alleviating poverty in Yogyakarta city since all of actors have not employed social capital well. In strengthening social capital, it needs the mixed between top down and bottom up approach in which the government, community and other stakeholders such as private business, universities and non-governmental organization actively involve in building and enhancing trust, norm and networks to implement Segoro Amarto Movement.Keywords: Segoro Amarto Movement (GSA), social capital, poverty
Distorsión de la imagen corporal en adolescentes con sobrepeso y obesidad
Authors: Carvajal Navarrete Natalia , Esparza Meza Eva María 
Published: September 2022

<p class="p1"><span class="s1">El objetivo del presente estudio fue determinar la distorsión en la percepción de la imagen corporal, en un grupo de 269 adolescentes (127 hombres y 142 mujeres) de entre 11 y 16 años, estudiantes de una Secundaria Técnica de la Ciudad de México. Para recabar la información se utilizaron el dibujo de la figura humana y un cuestionario breve, así como datos antropomórficos (peso y estatura) de cada participante. El análisis estadístico se llevó a cabo mediante el Paquete Estadístico para las Ciencias Sociales (SPSS), aplicando X<sup>2</sup> (ji-cuadrada), con un nivel de significancia de 0.05. Los resultados obtenidos muestran que existe una mayor subestimación de la imagen corporal a medida que el peso aumenta; lo mismo ocurrió con la negación de dicha subestimación, ya que se encuentra en mayores porcentajes en aquellos individuos con mayor peso. El grado de distorsión de la imagen corporal no varió en función al sexo ni la edad.<span class="Apple-converted-space"> </span></span></p>
Ensuring safe working conditions in the arrangement of household towns of overhauled buildings
Authors: Korol Elena A. , Petrosyan Rima S. 
Published: September 2022

Introduction. Construction production is characterized by special conditions for the production of works, which include the need to organize residential camps at the construction site to ensure balanced working and rest conditions for workers.
Materials and methods. For buildings of residential camps, design standards are provided that reflect not only the requirements common to all buildings and structures, but also take into account their temporary period of operation with possible reuse. The design of the territories of residential towns is also determined by the norms an.rules developed for them. The overhaul of buildings is subject to the same requirements for the organization of construction sites. However, repair and construction work carried out in conditions of dense urban development, in urbanized areas, predetermine an additional set of studies in the field of ensuring safe conditions for the production of repair and construction work in buildings in operation. The organization of the production of capital repairs also has its own characteristics associated with limiting the time they are carried out in an operated building in one shift to minimize the negative impacts from industrial noise on residents, the formation of construction waste, and the movement of vehicles. The purpose of the study is to identify factors that affect the safety of life and work of workers employed in the repair and construction industry, and to develop measures to reduce their impact in the production process.
Results. The result of the research is the proposed toolkit for assessing the factor of tightness of the territory in the design of residential towns for organizing the production process of capital repairs of buildings, taking into account labor safety requirements.
Conclusions. Formalization of requirements for the design and operation of residential camps in the implementation of regional programs for the overhaul of multi-apartment residential buildings is necessary, taking into account the cramped conditions for performing repair and construction processes of varying complexity in operated buildings, without resettling residents, and is harmonized with the requirements for safe working conditions in the process of new construction.