bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of traditional Chinese medicine Bailing capsule on renal anemia in maintenance hemodialysis patients
Authors: Li Yan-Lin , Cheng Fang , Chen Yan , Wang Jun , Xiao Zeng-Dong , Li Bin 
Published: April 2022

Abstract

Background:
Renal anemia (RA) is one of the most common complications in patients with end-stage renal disease, and it is also one of the reasons for the decline of quality of life and functional status in patients with end-stage renal disease. Traditional treatment methods often fail to achieve satisfactory therapeutic effects, so it is very necessary to find effective adjuvant treatment methods. Bailing capsule (BLC), a traditional Chinese medicine, which has been widely used in the treatment of RA in maintenance hemodialysis patients, but a systematic review of the efficacy and safety of this drug is currently lacking. Therefore, this study used meta-analysis to evaluate the efficacy and safety of BLC in the treatment of RA, in order to provide guidance for finding effective auxiliary methods for the treatment of RA in maintenance hemodialysis patients (MHP).

Methods:
Using the computer to retrieve PubMed, EMbase, Cochrane Library, CNKI, VIP Database, WANFANG Database, SinoMed from 1990 to 2021 and collecting the clinical randomized controlled trial and retrospective cohort study of BLC in the treatment of RA in MHP. Two researchers independently read and screened the literature, followed by evaluating the retrospective cohort studies that met the selection criteria using the Newcastle-Ottawa Scale (NOS) scale. The randomized controlled trial used the Cochrane manual standards to assess the risk of bias, and the RevMan 5.3 software was used to conduct a meta-analysis of the result data.

Results:
This study will use the method of meta-analysis to evaluate the clinical efficacy and incidence of adverse reactions of BLC in the treatment of RA in MHP through the primary and secondary outcome indicators.

Conclusion:
The results of this study will help clinicians find safe and effective adjuvant therapy in the treatment of RA in MHP.

OSF registration number:
DOI 10.17605/OSF.IO/732KP (https://osf.io/732kp).
The efficacy and safety of auricular point pressing therapy for knee osteoarthritis
Authors: He Jie , Ma Lin , Zhou Feng , Jiang Hongbo , Wang Huajie , Wang Xin , Zhao Yuxin 
Published: April 2022

AbstractBackground:Knee osteoarthritis (KOA) is one of the leading causes of disability. The effectiveness of auricular point pressing therapy for treating KOA remains controversial. This protocol describes the method of a systematic review and meta-analysis evaluating the effectiveness and safety of auricular point pressing therapy for treating KOA.Methods:Four English databases (PubMed, Embase, Cochrane Library databases and Web of Science) and 4 Chinese databases (China National Knowledge Infrastructure, Chinese Biomedical Literature Database, VIP Database for Chinese Technical Periodicals, and Wanfang) will be searched. All randomized controlled trials related to auricular point pressing therapy for KOA will be included. Extracted data will include publication details, basic information, demographic data, intervention details and patient outcomes. The primary outcome will be Western Ontario and McMaster Universities Osteoarthritis Index and visual analogue scale. Risk of bias will be assessed using the Cochrane Collaboration tool for assessing risk of bias. Article selection, data extraction and risk of bias assessment will be performed by 2 independent reviewers. If the meta-analysis is precluded, we will conduct a descriptive synthesis using a best-evidence synthesis approach. The strength of recommendations and quality of evidence will be assessed using the Grading of Recommendations Assessment Development.Results:The systematic review will provide evidence to assess the efficacy and safety of auricular point pressing therapy on KOA.Conclusion:The systematic review will provide evidence to assess the efficacy and safety of auricular point pressing therapy for KOA patients.Ethics and dissemination:For this review, ethical approval is not required. Patients will not be involved. The findings will be published in a peer-reviewed journal.INPLASY registration number:INPLASY 202220077.
A comparative study of the efficacy and safety of high-flow nasal cannula and nasal continuous positive airway pressure in neonatal respiratory distress syndrome
Authors: Wang Jiang-Jiang , Zhang Lei , Cai Na 
Published: April 2022

Abstract

Background:
When it comes to preterm newborns, respiratory distress syndrome (RDS) is the most frequent respiratory condition. Despite the fact that it is well acknowledged that preterm delivery plays a significant role, the causes of lung damage are still not completely understood. In newborns with extremely low birth weight and neonatal RDS, nasal continuous positive airway pressure has been suggested as the first respiratory assistance for spontaneous breathing. In the current research, we aim to carry out a meta-analysis to assess the effectiveness and safety of high-flow nasal cannula (HFNC) and non-invasive continuous positive airway pressure (nCPAP) in patients with neonatal respiratory distress syndrome (NRDS).

Methods:
We intend to search the following databases: PubMed, EMBASE, Cochrane Library, Wanfang database, China National Knowledge Infrastructure (CNKI), and Google Scholar, starting from their initial publication until February 2022, to identify randomized controlled trials comparing HFNC to nCPAP in patients with NRDS. The suitable papers will be chosen by 2 writers who will work independently of one another. Using the Cochrane updated technique for risk of bias, each included article will be subjected to an independent data extraction process by the 2 writers who will then independently evaluate the risk of bias. Consequently, a third author will be asked to address any discrepancies that may arise between the writers. It will be necessary to pool the data and do a meta-analysis with the help of the RevMan 5.3 software.

Results:
In this study, the effectiveness and safety of HFNC will be compared with those of nCPAP in patients with NRDS.

Conclusion:
If the results of this research are confirmed, they may serve as a summary of the most recent data for non-invasive respiratory assistance in NRDS.

Ethics and dissemination:
The study will require ethical approval.

Registration number:
DOI 10.17605/OSF.IO/BKSQ5
Effectiveness of five interventions used for prevention of gestational diabetes
Authors: Tang Qiongyao , Zhong Ying , Xu Chenyun , Li Wangya , Wang Haiyan , Hou Yu 
Published: April 2022

Abstract

Background:
Gestational diabetes mellitus (GDM) is associated with short- and long-term health issues for mother and child; preventing these complications is crucially important. This study aimed to perform a systematic review and network meta-analysis of the relationships among 5 interventions used to prevent GDM.

Materials and methods:
A comprehensive literature search was performed to pool evidence from inception to June 30, 2020. The type of studies was confined to randomized control trials and quasi-randomized control trials published in English investigating the interventions for preventing GDM, including physical activity, dietary intervention, probiotic intervention, mixed intervention, and inositol supplementation. The data were pooled together to report the odds ratio (OR) of GDM with a corresponding 95% credible interval (CrI) and generate a network plot, the surface under the cumulative ranking curve plot, and contribution plot. In addition, loop inconsistency was examined, and a funnel plot combined with Egger test was used to measure heterogeneity.

Results:
The network meta-analysis included 46 randomized control trials involving 16,545 patients. Compared with placebo, physical activity (OR: 0.64, 95% CrI: 0.46–0.88) and probiotic intervention (OR: 0.57, 95% CrI: 0.34–0.96) reduced the incidence of GDM significantly. However, dietary intervention, a combination of physical activity and diet intervention, and inositol supplementation did not significantly alter GDM risk.

Conclusions:
Physical activity and probiotic intervention are more effective than placebo in reducing the risk of developing GDM. Future work should focus on the type, duration, frequency, and timing of physical activity and probiotic intervention.
Acute abdomen caused by torsion of the omentum
Authors: Wang Yue , Huang Ran , Li Chun , Li Weisong 
Published: April 2022

Abstract

Rationale:
Torsion of the omentum and infarction are rare and unusual disorders that often present as acute abdominal pain in the population. The diagnosis of omental torsion is based on clinical and imaging examinations.

Patient concerns:
A 7-year-old girl presented with acute right lower quadrant abdominal pain, with symptoms resembling acute appendicitis.

Diagnosis:
The patient was diagnosed with omental torsion based on imaging and laparoscopy.

Interventions:
Laparoscopic exploration was performed.

Outcomes:
The patient was discharged seven days after satisfactory postoperative recovery.

Lessons:
Omental torsion should be included in the differential diagnosis of acute abdominal pain, particularly in patients with free hemorrhagic fluid in the abdominal cavity and pelvis.
Low dose sacubitril/valsartan is effective and safe in hemodialysis patient with decompensated heart failure and hypotension
Authors: Feng Yunlin , Li Wenhua , Liu Hongjun , Chen Xiuling 
Published: April 2022

Abstract

Rationale:
Severe heart failure in chronic hemodialysis (HD) patients is a great treatment challenge. Here we reported a chronic HD patient with the lowest ejection fraction reported so far and hypotension who well tolerated and benefited from angiotensin-receptor neprilysin inhibitor (ARNI) treatment.

Patient concerns:
This case was a 67 year old lady with decompensated heart failure and hypotension who was on regular HD. Intensified hemofiltration failed to improve her heart failure symptoms and was also retarded by hypotension.

Diagnosis:
Chronic HD with decompensated heart failure.

Interventions:
In addition to regular HD, low does sacubitril/valsartan was initiated and titrated from 12/13 mg to 24/26 mg twice daily.

Outcomes:
Sacubitril/valsartan treatment was well tolerated and did not affect ultrafiltration during HD treatment. Transthoracic echocardiology at 3 months after initiation of ARNI treatment indicated significant improvement of both systolic and diastolic cardiac function. The patient has improved from New York Heart Association class 4 to class 2.

Lessons:
Low does ARNI treatment could effectively improve cardiac function in HD patients with heart failure and hypotension. It was also safe and well tolerated.
An early diagnostic case of noonan syndrome with leukocytosis and pulmonary stenosis
Authors: Olteanu Carmen Cristina , Hodea Ana-Maria , Bulescu Cristian , Bârsan Andrei , Platon Pavel , Lază Ovidiu , Moldovan HoraŢiu 
Published: April 2022

Abstract

Rationale:
Noonan syndrome is a genetic disorder with variable clinical manifestations that affects different systems. Among the multitude of clinical findings, the main characteristics are unique facial traits, low height, and congenital cardiac abnormalities. Recognizing such a syndrome is of great importance because of its involvement of multiple organs. Therefore, a systematic and thorough evaluation according to the guidelines for the assessment and management of Noonan syndrome is needed.

Patient concerns:
A female infant, 3 months old, presented with a difficult neonatal period (respiratory distress, generalized cyanosis), typical facial dysmorphia, evolutionary height hypotrophy, persistent leukocytosis, factor VII deficit, and severe pulmonary stenosis.

Diagnosis:
Echocardiography showed severe pulmonary valve stenosis, mild pulmonary regurgitation, a 6.5 mm ostium secundum atrial septal defect, and a persistent ductus arteriosus. Laboratory reports revealed leukocytosis with monocytosis, anemia, and thrombocytopenia, but no infectious source was found.

Interventions:
In this context, a pulmonary balloon valvuloplasty was performed, with a significant decrease of the transpulmonary gradient.

Outcome:
The patient was genetically tested, and the reports were positive for Noonan syndrome (mutation in exon 13 of PTPN 11). At 3years of age, she underwent open-heart repair of the atrial septal defect and significant recurrent pulmonary stenosis. The postoperative course was uneventful, and the patient remained asymptomatic at 6months follow-up.

Conclusions:
The diagnosis was initially suggested by the characteristic unique clinical events associated with cardiac involvement and confirmed later through genetic molecular testing. Prompt treatment of the severe life-threatening pulmonary valve stenosis was important, and the patient underwent additional interventions, after which she remained stable.
Use of Anticoagulants in COVID-19: A Review
Authors: Ngu Sam , Smith John Kolton , Goldin Mark 
Published: April 2022

Background:
Coronavirus disease 2019 (COVID-19) is associated with elevated rates of major and fatal thrombotic events, postulated to be the result of a hypercoagulable state mediated through inflammatory and immunomodulatory mechanisms. Early observational studies showed that disease severity and elevated serum D-dimer levels can predict thrombotic risk in patients hospitalized with COVID-19 and reported an alarming phenomenon of breakthrough thrombosis despite standard-of-care prophylaxis, suggesting the need for enhanced thromboprophylactic strategies.

Areas of Uncertainty:
Data on anticoagulant agent selection, dosing, and duration for COVID-19 inpatients are now poised to inform updated professional society guidance. However, there remains limited high-quality data regarding postdischarge and especially ambulatory patients with COVID-19.

Data Sources:
This review includes published, peer-reviewed, observational, and randomized controlled trial data and major professional society guidance informing thrombosis prevention and treatment in patients with COVID-19.

Therapeutic Advances:
There remains great variability in the approach to anticoagulation in COVID-19. This article will review pathogenesis of COVID-related thrombosis and the evidence guiding thromboprophylaxis particularly in inpatients, with attention to the INSPIRATION, ACTION, RAPID, HEP-COVID, and multiplatform trials. Emerging thromboprophylaxis data from the postdischarge setting (particularly the recently published MICHELLE trial), and the outpatient setting, will be examined. Finally, thrombosis treatment considerations will briefly be reviewed.

Conclusions:
Substantial high-quality data support practice changes to COVID-19 thromboprophylaxis. Risk stratification by setting, disease severity, and biomarkers such as D-dimer is critical in considering choice, dose, and duration of anticoagulants.
Paths to Motherhood for Women with Cystic Fibrosis
Authors: Bray Leigh Ann , Campbell Caitlin Marley , Brown Janet , Ladores Sigrid 
Published: April 2022

Abstract

Purpose:
Cystic fibrosis (CF) is no longer a disease limited to childhood. With medical advancements, many of those with CF live into adulthood and have similar life goals as their non-CF peers. Most women with CF want to become mothers. However, available options and the related decision-making process is not well understood. The purpose of this study was to explore the decision-making framework of women with CF to better understand the factors they consider when deciding on a path to motherhood.

Study Design and Methods:
Qualitative interviews were performed using a grounded theory approach. Inclusion criteria were women with CF who became mothers through biological pregnancy, adoption, or gestational surrogacy. Results: Twenty-five mothers with CF were interviewed. A distinct decision-making process was identified through which women started with a desire for motherhood, assessed several factors, then eventually took the path they felt was right for them and their family.

Clinical Implications:
Our findings provide women with CF a framework that other women with CF have used to assist in making decisions about their reproductive options. Conversations about family planning should occur early and regularly between women with CF and their health care providers. The decision-making process to achieve motherhood for women with a chronic illness, such as CF, includes consideration of unique factors that should be included in clinical conversations.
Post-Concussion Symptom Catastrophizing Scale: Preliminary reliability and validity analysis of cross-sectional data
Authors: Buzzanca Katherine E. , Addeo Russell , Lahey Sarah M. , Houck Zachary , Beneciuk Jason M. 
Published: April 2022

ABSTRACT

Objective
Describe cross-sectional relationships between post-concussion symptom catastrophizing and patient-level factors in a post-concussion cohort.

Design
This cross-sectional study was conducted in an outpatient rehabilitation hospital concussion clinic and consisted of adults undergoing a neuropsychological evaluation. Cronbach’s alpha (α) assessed internal consistency for PCS-CS (Post-Concussion Symptom Catastrophizing Scale) total scores. Pearson r correlation coefficients assessed construct validity among emotional function measures and PCS-CS total scores at initial evaluation. Hierarchical regression models were used to assess criterion validity.

Results
Excellent internal consistency was observed for PCS-CS total scores (α = .953). The PCS-CS was significantly correlated with cause of injury (r = -.223, p < .01), litigation consideration (r = .309, p < .05), and history of psychiatric illness (r = .198, p < .01). The PCS-CS was significantly correlated with emotional functioning [PHQ-9 (r = .600, p < .05); GAD7 (r = .602 p < .05)], symptom rating [SCAT5 (r = .477, p < .05)], and cognitive functioning [RBANS (r = -.238, p < .05)] measures. The final regression model explained 64.7% variance in PCS-CS total scores and included the GAD-7 (b = 1.038, β = 0.466, p = 0.001) as a unique predictor.

Conclusion
Results indicate strong, positive relationships between anxiety and catastrophizing at initial neuropsychological evaluation in a post-concussion sample.
Physical Activity and Physical Activity Participation Barriers Among Adults 50 years and Older During the COVID-19 Pandemic
Authors: Wingood Mariana , Peters Denise M. , Gell Nancy M. , Brach Jennifer S. , Bean Jonathan F. 
Published: April 2022

Abstract

Objective
We examined changes in PA from pre-COVID-19 to during the COVID-19 pandemic and the factors associated with reduced PA levels among adults 50 years and older.

Design
Participants of a validation study were stratified into being “less active than before” or “equally or more active than before” COVID-19. Multivariable manual backwards analyses were used to identify self-reported barriers associated with the reduction in PA.

Results
Reduced PA levels during COVID-19 were reported among 244/503 participants (43%). After adjusting for demographics and health conditions, factors that increased the odds of reduced PA levels during COVID-19 were lacking access to workout places, feeling too anxious, and difficulty committing to PA. Factors that decreased the odds of reduced PA levels during COVID-19 were self-identifying a heart or lung associated diagnosis that impacts PA and having a 12-month retrospective history of falling.

Conclusions
The PA participation barriers identified to be associated with a reduction in PA can be used as a starting point for a conversation regarding PA participation during COVID-19.
Automated Dual-energy Computed Tomography-based Extracellular Volume Estimation for Myocardial Characterization in Patients With Ischemic and Nonischemic Cardiomyopathy
Authors: Abadia Andres F. , Aquino Gilberto J. , Schoepf U. Joseph , Wels Michael , Schmidt Bernhard , Sahbaee Pooyan , Dargis Danielle M. , Burt Jeremy R. , Varga-Szemes Akos , Emrich Tilman 
Published: April 2022

Objectives:
We aimed to validate and test a prototype algorithm for automated dual-energy computed tomography (DECT)-based myocardial extracellular volume (ECV) assessment in patients with various cardiomyopathies.

Methods:
This retrospective study included healthy subjects (n=9; 61±10 y) and patients with cardiomyopathy (n=109, including a validation cohort n=60; 68±9 y; and a test cohort n=49; 69±11 y), who had previously undergone cardiac DECT. Myocardial ECV was calculated using a prototype-based fully automated algorithm and compared with manual assessment. Receiver-operating characteristic analysis was performed to test the algorithm’s ability to distinguish healthy subjects and patients with cardiomyopathy.

Results:
The fully automated method led to a significant reduction of postprocessing time compared with manual assessment (2.2±0.4 min and 9.4±0.7 min, respectively,P<0.001). There was no significant difference in ECV between the automated and manual methods (P=0.088). The automated method showed moderate correlation and agreement with the manual technique (r=0.68, intraclass correlation coefficient=0.66). ECV was significantly higher in patients with cardiomyopathy compared with healthy subjects, regardless of the method used (P<0.001). In the test cohort, the automated method yielded an area under the curve of 0.98 for identifying patients with cardiomyopathies.

Conclusion:
Automated ECV estimation based on DECT showed moderate agreement with the manual method and matched with previously reported ECV values for healthy volunteers and patients with cardiomyopathy. The automatically derived ECV demonstrated an excellent diagnostic performance to discriminate between healthy and diseased myocardium, suggesting that it could be an effective initial screening tool while significantly reducing the time of assessment.
Sideroxyarcus emersonii gen. nov. sp. nov., a neutrophilic, microaerobic iron- and thiosulfate-oxidizing bacterium isolated from iron-rich wetland sediment
Authors: Kato Shingo , Itoh Takashi , Iino Takao , Ohkuma Moriya 
Published: April 2022

A neutrophilic iron-oxidizing bacterium, strain MIZ01T, which was previously isolated from a wetland in Ibaraki, Japan, was taxonomically characterized in detail. Strain MIZ01T was a motile, curved-rod shaped, Gram-stain-negative bacterium. It was able to grow at 10–40 °C (optimally at 30–35 °C) and at pH 5.5–7.0 (optimally at pH 6.0). It grew microaerobically and chemolithoautotrophically using thiosulfate, in addition to ferrous iron, as the sole electron donor. Major cellular fatty acids of strain MIZ01T were C16 : 1
ω7c/C16 : 1
ω6c and C16 : 0. The complete genome sequence (2.74 Mbp) was determined, showing that its DNA G+C content was 60.0 mol%. Phylogenetic analyses indicated that strain MIZ01T belonged to the family

Gallionellaceae

, class

Betaproteobacteria

, and was closely related to an isolate tentatively named ‘Sideroxydans lithotrophicus’ ES-1 (98.2 % of 16S rRNA gene sequence similarity). Based on its phenotypic and phylogenetic characteristics, we conclude that strain MIZ01T represents a new genus and species in the family

Gallionellaceae

for which we propose the name Sideroxyarcus emersonii gen. nov., sp. nov. The type strain is strain MIZ01T (=JCM 39089T=DSM 111897T).