bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison of antibacterial property of herbal plant–based bio-active extract loaded polymer electrospun nanofibrous mat wound dressings
Authors: Adamu Biruk Fentahun , Gao Jing , Tan Shaojie , Gebeyehu Esubalew K 
Published: May 2022

Treating wound is challenging if there is microbial colonization. In this paper, we tried to review comparison of bacterial inhibition zone of different herbal plant bioactive loaded polymer electrospun nanofibrous wound dressings. A systematic literature search called preferred reporting items for systematic reviews and meta-analyses (PRISMA) was used to review bacterial inhibition zone of the different herbal plant bioactive loaded polymer electrospun nanofibrous mats used for wound dressing applications. The literatures were searched from PubMed, Scopus, Web of Science, and Google Scholar databases published in English from 2010 to 2021. Two hundred articles were searched out; from these, 93 articles are selected and studied their bacterial inhibition zone, among them eight have the highest bacterial inhibition zone greater than or equal to 20 mm. From the studied plant bioactive extract loaded polymer electrospun nanofibrous mat wound dressings, PVA/ Tridax procumbensviz have the highest antibacterial property (42 mm and 35 mm bacterial inhibition zone to Staphylococcus aureus and Escherichia coli, respectively). The second highest antibacterial property is PVA /honey/Curcuma longa with bacterial inhibition zone of 38 mm to S. aureus and the third one is PCL/carboxyethyl chitosan/PVA/ Matricaria chamomile L. with an inhibition zone of 37.5 mm to E. coli bacteria.
Safety and efficacy of remote ischemic conditioning combined with intravenous thrombolysis for acute ischemic stroke: A multicenter, randomized, parallel-controlled clinical trial (SERIC-IVT) Study design and protocol
Authors: Abuduxukuer Reziya , Guo Zhen-Ni , Zhang Peng , Qu Yang , Yang Yi 
Published: May 2022

Rationale: Remote ischemic conditioning (RIC) combined with intravenous thrombolysis (IVT) may improve functional outcomes in patients with acute ischemic stroke (AIS). Aim: To assess the efficacy and safety of RIC combined with IVT for AIS. Methods and design: SERIC-IVT is a multicenter, randomized, parallel-controlled, blinded endpoint clinical trial. A total of 558 patients with AIS who underwent IVT therapy will be randomly assigned 1:1 to receive RIC or sham-RIC plus standard medical therapy. The cuff pressures of the RIC group and the sham-RIC group will be 200 mm Hg and 60 mm Hg, respectively, performed twice a day for seven consecutive days. Study outcomes: The primary efficacy outcome is the proportion of patients with a favorable functional outcome as defined as a modified Rankin Scale ⩽ 1 at 90 days. Safety outcomes include mortality and adverse events within 90 days. Sample size estimates: A sample size of 558 patients with AIS (279 in each group) will allow detection of a shift of 13.14% toward favorable functional outcome at 90 days (modified Rankin Scale ⩽ 1) with 5% significance and 80% power. Discussion: RIC is a promising adjuvant treatment for AIS. SERIC-IVT will inform on whether RIC treatment combined with IVT improves functional outcomes in AIS patients and identify any safety issues.
The effects of vitamin E on non-proliferative diabetic retinopathy in type 2 diabetes mellitus: Are they sustainable with 12 months of therapy
Authors: Ho J-Ian , Ng En Yng , Chiew Yilynn , Koay Yan Yi , Chuar Pei Fen , Phang Sonia Chew Wen , Ahmad Badariah , Kadir Khalid Abdul 
Published: May 2022

Introduction: Prolonged uncontrolled hyperglycaemia has shown to cause oxidative stress, inflammation, thrombosis and upregulation of angiogenesis in diabetics, which all contributes to diabetic retinopathy development and progression. Vitamin E is found to have anti-inflammatory, anti-oxidative, anti-thrombogenic and anti-angiogenesis which could play an important role in early treatment of diabetic retinopathy. This study aims to investigate the effect of Tocotrienol-rich vitamin E (Tocovid) on the progression of retinal microhaemorrhages and diabetic macular oedema in patients with diabetic retinopathy. Method: This is a multi-centred, randomized, double-blinded, placebo-controlled trial which involved 55 eligible participants. The participants in the treatment group ( n = 22) received Tocovid 200 mg twice daily while those in the placebo group ( n = 23) would receive placebo twice daily. Both groups will be on the treatment for a total duration of 12 months. Both retinal signs will be assessed at baseline, 2 months, 6 months and 12 months of treatment to determine the progression of diabetic retinopathy. Serum vascular endothelial growth factor which reflects on the angiogenesis process in the eye was analysed as well at similar time points as the retinal findings. Results: After 12 months of treatment, the placebo group had a significant increase of 23.42% in retinal microhaemorrhages ( p < 0.05), but the Tocovid group had no significant changes. Moreover, the Tocovid group showed a significant decrease of 48.38% in area of diabetic macular oedema over the 12 months period ( p < 0.05), but the placebo group had no significant changes. Meanwhile, there was no significant difference in serum vascular endothelial growth factor level when comparing between both groups. Conclusion: These findings could indicate that Tocovid has an important role in preventing early diabetic retinopathy progression.
Survival and recovery modeling of acute kidney injury in critically ill adults
Authors: Brothers Todd N , Strock Jacob , LeMasters Traci J , Pawasauskas Jayne , Reed Ronald C , Al-Mamun Mohammad A 
Published: May 2022

Objectives: Acute kidney injury is common among the critically ill. However, the incidence, medication use, and outcomes of acute kidney injury have been variably described. We conducted a single-center, retrospective cohort study to examine the risk factors and correlates associated with acute kidney injury in critically ill adults with a particular focus on medication class usage. Methods: We reviewed the electronic medical records of all adult patients admitted to an intensive care unit between 1 February and 30 August 2020. Acute kidney injury was defined by the 2012 Kidney Disease: Improving Global Outcomes guidelines. Data included were demographics, comorbidities, symptoms, laboratory parameters, interventions, and outcomes. The primary outcome was acute kidney injury incidence. A Least Absolute Shrinkage and Selection Operator regression model was used to determine risk factors associated with acute kidney injury. Secondary outcomes including acute kidney injury recovery and intensive care unit mortality were analyzed using a Cox regression model. Results: Among 226 admitted patients, 108 (47.8%) experienced acute kidney injury. 37 (34.3%), 39 (36.1%), and 32 patients (29.6%) were classified as acute kidney injury stages I–III, respectively. Among the recovery and mortality cohorts, analgesics/sedatives, anti-infectives, and intravenous fluids were significant ( p-value < 0.05). The medication classes IV-fluid electrolytes nutrition (96.7%), gastrointestinal (90.2%), and anti-infectives (81.5%) were associated with an increased odds of developing acute kidney injury, odd ratios: 1.27, 1.71, and 1.70, respectively. Cox regression analyses revealed a significantly increased time-varying mortality risk for acute kidney injury-stage III, hazard ratio: 4.72 (95% confidence interval: 1–22.33). In the recovery cohort, time to acute kidney injury recovery was significantly faster in stage I, hazard ratio: 9.14 (95% confidence interval: 2.14–39.06) cohort when compared to the stage III cohort. Conclusion: Evaluation of vital signs, laboratory, and medication use data may be useful to determine acute kidney injury risk stratification. The influence of particular medication classes further impacts the risk of developing acute kidney injury, necessitating the importance of examining pharmacotherapeutic regimens for early recognition of renal impairment and prevention.
Effect of the whole seamless connection of nursing from WeChat interactive platform on stigma and quality of life in patients with urinary system cancer
Authors: Hao Haiyan , Yang Xinyu , Zhu Huixia , Wang Ziheng , Zhang Haiyan , Huang Chunxia 
Published: May 2022

Objective To evaluate the effects of intervention by “whole seamless connection of nursing from WeChat interactive platform” on stigma and quality of life of the patients with urinary system cancer. Methods Overall, 80 patients with urinary cancer were randomly divided (40 cases per group) into control and observation groups. Routine nursing was provided to the control group, whereas positive psychological intervention was provided to the intervention group through a “whole seamless connection of nursing from the WeChat interactive platform” in addition to routine nursing. The Chinese version of social impact and cancer patients’ quality of life scales were used to evaluate the effects before and after the intervention. Results After the intervention, the total score for stigma was significantly lower ( p < 0.01), while that of quality of life was higher ( p < 0.05) in the observation group relative to the control group. Conclusions The whole seamless connection of nursing from the WeChat interactive platform could reduce stigma and improve the quality of life of patients with urinary cancer.
Workplace Psychological Distress: A Concept Analysis
Authors: Mopkins Dawn 
Published: May 2022

Background: Workplace psychological distress (WPD) significantly impacts employees’ mental and physical well-being. However, WPD has not been well-defined in the literature as a concept. This concept analysis aims to clarify the concept of WPD and promote the use of the term in occupational health nursing research. Methods: Strategies introduced by Walker and Avant’s conceptual analysis method will be utilized to conceptualize WPD and its impact on employees. A literature search was conducted using Cumulative Index of Nursing and Allied Health Literature (CINAHL), Business Source Complete, and APA PsycArticles. The keyword search included the terms “workplace” AND “employee” AND “psychological distress.” Results: Antecedents of WPD are an increase in job demands, lack of control, low support, and workplace bullying. Defining attributes for WPD are extreme fatigue, role conflict, and time pressures. Consequences of WPD were identified as mental disorders, physical disorders, and loss in productivity. This concept was further illustrated using a model, borderline, and contrary case. Discussion/Conclusion: Identifying signs of WPD is of great importance in caring for employees in the workplace. Occupational health nurses can use information obtained from a workplace assessment to develop policies, implement well-being programs, and provide employee referrals.
Paper 02: A Modified Lemaire Lateral Extra-Articular Tenodesis in High Risk Adolescents Undergoing Anterior Cruciate Ligament Reconstruction: Two-Year Clinical Outcomes
Authors: Cordasco Frank , Perea Sofia Hidalgo , Brusalis Christopher , Green Daniel 
Published: May 2022

Objectives: This study aimed to evaluate the safety and efficacy of performing a lateral extra-articular tenodesis (LET) with a modified Lemaire technique (MLT) in conjunction with anterior cruciate ligament reconstruction (ACLR) in children and adolescents at increased risk for failed ACLR. Methods: A consecutive series of patients ≤19 years who underwent simultaneous ACLR and LET with minimum two-year follow-up data were reviewed. Patients were indicated for LET when one or more of the following risk factors were present: participant in high-risk competitive sport such as football, lacrosse, soccer or basketball, grade 3 pivot shift, hyperlaxity (Beighton score > 6), recurvatum, revision ACLR, contralateral ACLR, or chronic ACL insufficiency. ACLR was performed using either full-thickness quadriceps tendon (QUAD) for skeletally immature patients or bone-patellar tendon-bone (BTB) autograft for skeletally mature patients. All-epiphyseal (AE) or complete transphyseal (CT)techniques were used depending on patients’ skeletal maturity. At a minimum two-year follow-up, patient-reported outcome measures included Single Assessment Numeric Evaluation (SANE), Pediatric International Knee Documentation Committee (Pedi-IKDC), and the HSS Functional Activity Brief Scale (HSS Pedi-FABS) scores. Return-to-sport (RTS)data and second surgeries were also obtained. Results: Sixty-one consecutive patients (mean age 15.17 ±1.73 years, range 11-19 years, 62% female) were analyzed (Table 1). 59 patients (97%) participated in organized sports including soccer, basketball, football and lacrosse, with soccer being the most popular one. The average grade at the time of surgery was 9th grade. Ten patients (16%) were revision ACLR procedures. Seven (11%) patients underwent AE and 54 (89%) underwent CT ACLR. Forty-two (69%) cases employed a QUAD autograft, while 19 (31%) utilized a BTB autograft. All patients underwent a LET with a MLT and 2 patients underwent simultaneous implant mediated guided growth with a plate for structural genu valgum. At two-year follow-up, mean SANE score was 95, median Pedi-IKDC score was 91, and median HSS-Pedi Fabs score was 27. RTS rate was 91.8%. Ten patients had subsequent surgical procedures, including two hardware removal procedures for hemiepiphysiodesis, three contralateral ACLR, three meniscus surgeries, one lysis of adhesions, and one revision ACLR for BTB graft re-rupture. Two patients were lost to follow-up and excluded from the study. Conclusions: The findings suggest that concomitant LET and ACLR in adolescent patients with risk factors for failed ACLR is associated with favorable patient-reported outcomes, high return to sports participation, and low ACL re-rupture rate at two years follow-up. [Table: see text]
Paper 05: Glenoid Labral Tears are associated with Increased Neurofilament Innervation
Authors: Beretov Julia , Marvi Salman , Lam Patrick , Murrell George , Murphy Geoffrey 
Published: May 2022

Objectives: Pain is a common presentation following glenohumeral labral injuries. However, the source of that pain is undetermined. We aimed to determine if there is a differential expression of nerve fibres around the glenoid labrum and if torn labra have increased neuronal expression compared to untorn labra. Methods: Labral tissue was collected at 3, 5, 9 and 12 o clock during total shoulder arthroplasty (n = 7). Samples were also collected at 3, 5 and 12 o clock during rotator cuff repair (n = 16), anterior labral repair (n = 6), type II superior labral anterior to posterior (SLAP) repair (n = 4) and capsular release for idiopathic capsulitis (n = 5). Sections were immunostained with antibodies to neurofilament, a specific neuronal marker which is used to identify central and peripheral nerve fibres, and the concentration and intensity of immunostained-positive cells assessed. Results: The concentration of neurofilament staining was similar in the superior, anterior, posterior and inferior glenoid labrum in untorn labra (8 neurofilament expressing cells/mm2, p > 0.05). Torn labra exhibited a 3-4-fold increase in neuronal expression which was isolated to the location of the tear in SLAP (p = 0.09) and anterior labral tears (p = 0.02). The concentration of neurofilament expressing cells in torn glenoid labrum samples were comparable to the glenoid labrum of adhesive capsulitis samples (p > 0.05). Figure 3. Mean (SD) neurofilament expressing cells per mm2 at 12 o’clock (A), 3 o’clock (B) and 5 o’clock (C) using labral tissue from patients with either a; RCT (n = 16), anterior labral tear (n = 6), SLAP tear (n = 4) or a frozen shoulder (n = 5). *p <0.05 compared using a one-way ANOVA with post-hoc analysis. Conclusions: This study supports the hypothesis that following a traumatic tear of the anterior or superior labrum, the labrum in that region becomes populated with new nerves fibres and that these fibres are likely to be responsible for many of the symptoms noted by patients with superior (SLAP) and/or anterior labral (Bankart) tears.
Paper 07: Predictors of Return to Sport in High-Level Athletes Following Hip Arthroscopy for Femoroacetabular Impingement
Authors: Monahan Peter , Jimenez Andrew , Owens Jade , Maldonado David , Saks Benjamin , Sabetian Payam , Ankem Hari , Lall Ajay , Domb Benjamin 
Published: May 2022

Objectives: The purpose of this study is to identify clinical and radiographic factors that predict return to sport in high-level athletes and to determine thresholds for significant predictors. Methods: Data were reviewed on all patients who underwent primary hip arthroscopy between November 2008 and August 2018. Patients were included if they played professional, college, or high school sports within 1 year before surgery and had preoperative, 3-month, 1-year, and 2-year postoperative patient reported outcome (PRO) scores for modified Harris Hip Score (mHHS), Hip Outcome Score-Sport Specific-Subscale (HOS-SSS), and Non-Arthritic Hip Score (NAHS). Patients were divided into groups based on whether they returned to sport (RTS). Multivariate logistic regression and receiver operator characteristic (ROC) analysis were used to evaluate the correlation between significant variables and RTS. Results: A total of 136 patients with a mean age of 20.8 ± 7.07 years were included. Competition level, postoperative alpha angle, change in alpha angle, and postoperative PROs were significantly different between groups. The multivariate logistic regression model identified postoperative alpha angle as a statistically significant predictor of return to sport [P < .001, S > 9.97 (OR 0.85, CI 0.79-0.91)]. The ROC curve for postoperative alpha angle demonstrated acceptable discrimination between patients returning to sport and patients not returning to sport with an area under the curve of 0.71 and a threshold value of 46˚. Athletes with a postoperative alpha angle ≤ 46˚ returned to sport at a rate of 71.2%, while those with a postoperative alpha angle > 46˚ returned to sport at a rate of 28.1% [(P < .001, S > 9.97 (OR 6.3, CI 2.6-15.2)] Conclusions: Postoperative alpha angle was identified as a predictor of return to sport in high-level athletes. The odds of returning to sport were 6.3 times greater in athletes with postoperative alpha angles ≤ 46˚ compared to athletes with angles > 46˚.
Paper 12: Biomechanical Comparison of Anatomic Restoration of the Ulnar Footprint Versus Traditional Ulnar Tunnels in Ulnar Collateral Ligament Reconstruction
Authors: Chang Edward , Looney Austin , Roach William , Clark DesRaj , Nagda Sameer , Colantonio Anthony Le Donald 
Published: May 2022

Objectives: Current techniques for ulnar collateral ligament (UCL) do not reproduce the anatomic ulnar footprint of the UCL. The purpose of this study was to describe a novel UCL reconstruction technique that utilizes proximal-to-distal ulnar bone tunnels to better recreate the anatomy of the UCL and compare the biomechanical profile at time zero between this technique, the native UCL, and the traditional docking technique. Our hypothesis was that the biomechanical profile of the anatomic technique is similar to the native UCL and traditional docking technique. Methods: Ten matched cadaveric elbows were potted with the forearm in neutral rotation. The palmaris longus tendon graft was harvested, and bones were sectioned 14 cm proximal and distal to the elbow joint. Specimen testing included: (1) native UCL testing performed at 90° flexion with 0.5 Nm valgus moment preload, (2) cyclic loading from 0.5-to-5 Nm valgus moment for 1000 cycles at 1 Hz, and (3) load to failure at 0.2 mm/s. Elbows then underwent UCL reconstruction with one elbow of each pair receiving the classic docking technique using either anatomic (proximal-to-distal) or traditional (anterior-to-posterior) tunnel locations. Specimen testing was then repeated, as described above. Results: There was no difference between maximum load at failure or valgus angle between the anatomic or traditional tunnel location techniques (34.90 ± 10.65 Nm vs. 37.28 ± 14.26 Nm, P = 0.644) or the native UCL (45.83 ± 17.03 Nm, P = 0.099). Additionally, there was no difference in valgus angle after 1000 cycles across the anatomic (4.58 ± 1.47°), traditional (4.08 ± 1.28°), or native UCL (4.07 ± 1.99°). Anatomic group and the native UCL had similar valgus angles at failure (24.13 ± 5.86° vs. 20.13 ± 5.70°, P = 0.083), while the traditional group had a higher valgus angle at failure compared to the native UCL (24.88 ± 6.18° vs. 19.44 ± 5.86°, P = 0.015). Conclusions: UCL reconstruction with the docking technique utilizing proximal-to-distal ulnar tunnels to restore the anatomic ulnar footprint better recreates the anatomy of the UCL while providing valgus stability comparable to reconstruction with docking technique using traditional anterior-to-posterior ulnar tunnel locations. These results suggest that utilization of the anatomic tunnel location in UCL reconstruction has similar biomechanical properties compared to the traditional method at the time of initial fixation (i.e., not accounting for healing following reconstruction in vivo) while keeping the ulnar tunnels further from the ulnar nerve. Further studies are warranted to determine if an anatomically based UCL reconstruction results in differing outcomes compared to traditional reconstruction techniques.
PAPER 14: Excision of Hook of Hamate Fractures in Elite Baseball Players: Surgical Technique and Return to Play
Authors: Leibman Matthew , Engler Ian 
Published: May 2022

Objectives: Hook of hamate fractures are relatively common in baseball players, but diagnosis and surgical technique can be challenging. Outcomes following surgical excision, as well as optimal surgical technique, in elite baseball players have not been clearly established. Our hypothesis was that excision of hook of hamate fractures in elite professional and collegiate baseball players with a tailored technique would lead to high rates of return to play within a short time. Methods: eview of a single academic hand surgery practice from 2006-2020 found 42 elite athletes competing at professional (20) or varsity collegiate (22) baseball levels who underwent surgical excision of 42 hook of hamate fractures with a standardized technique. The clinical history, timing of surgery, complications, and time to return to play were recorded for each patient. Results: All patients underwent an excision of their hook of hamate fracture at an average of 7.2 weeks (range 0.5 – 52 weeks) from the onset of symptoms. All patients but one were able to return to full pre-injury level of baseball participation within 6 weeks from the date of surgery, with a mean return to sport of 5.4 weeks (range 3-8 weeks). Two patients returned to the operating room – one for scar tissue formation causing ulnar nerve compression and one for residual bone fragment causing pain and ulnar nerve compression. Conclusions: Surgical excision of hook of hamate fractures in elite baseball players showed a very high rate of return to play within six weeks. Meticulous adherence to the described surgical technique tailored to athletes optimizes clinical outcomes and avoids complications.