bluuebunny/crossref_metadata_2025_split huggingface dataset:
Direct Visualization of the Evolution of a Single‐Atomic Cobalt Catalyst from Melting Nanoparticles with Carbon Dissolution
Authors: Zhang Luyao , Li Yanyan , Zhang Lei , Wang Kun , Li Yingbo , Wang Lei , Zhang Xinyu , Yang Feng , Zheng Zhiping 
Published: May 2022

AbstractTransition metal single‐atom catalysts (SACs) are of immense interest, but how exactly they are evolved upon pyrolysis of the corresponding precursors remains unclear as transition metal ions in the complex precursor undergo a series of morphological changes accompanied with changes in oxidation state as a result of the interactions with the carbon support. Herein, the authors record the complete evolution process of Co SAC during the pyrolysis a Co/Zn‐containing zeolitic imidazolate framework. Aberration‐corrected environmental TEM coupled with in‐situ EELS is used for direct visualization of the evolution process at 200–1000 °C. Dissolution of carbon into the nanoparticles of Co is found to be key to modulating the wetting behavior of nanoparticles on the carbon support; melting of Co nanoparticles and their motion within the zeolitic architecture leads to the etching of the framework structure, yielding porous C/N support onto which Co‐single atoms reside. This uniquely structured Co SAC is found to be effective for the oxidation of a series of aromatic alkanes to produce selective ketones among other possible products. The carbon dissolution and melting/sublimation‐driven structural dynamics of transition metal revealed here will expand the methodology in synthesizing SACs and other high‐temperature processes.
A Space‐Time Conversion Vehicle for Programmed Multi‐Drugs Delivery into Pancreatic Tumor to Overcome Matrix and Reflux Barriers
Authors: Huo Taotao , Zhang Xiaoyi , Qian Min , Nie Huifang , Liang Dong , Lin Chenteng , Yang Yafeng , Guo Wei , Lächelt Ulrich , Huang Rongqin 
Published: May 2022

AbstractThe numerous biological barriers, which limit pharmacotherapy of pancreatic carcinoma, including inadequate drug accumulation in the tumor environment, a dense extracellular matrix (ECM) and efficient drug‐efflux mechanisms, illustrate the requirement of multifunctional delivery systems to overcome the individual barriers at the right place at the right time. Herein, a space–time conversion vehicle based on covalent organic framework (COF)‐coated mesoporous silica nanospheres (MSN) with a sandwiched polyethyleneimine (PEI) layer (MPCP), is designed. The space‐specific drugs‐loaded vehicle (MGPPCLP) is obtained by separately incorporating a chemotherapeutic agent (gemcitabine, G) into the MSN core, a P glycoprotein inhibitor (LY 335979, P) into the PEI layer, and an extracellular matrix disruptor (losartan, L) into the COF shell. Thereafter, a programmed drug delivery is achieved via the ordered degradation from COF shell to MSN core. Sequential release of the individual drugs, synergized with a change of nanoparticle surface charge, contribute to an obvious extracellular matrix distraction, distinct drug efflux inhibition, and consequently enhance chemotherapeutic outcomes in pancreatic carcinoma. This MPCP‐based vehicle design suggests a robust space–time conversion strategy to achieve programmed multi‐drugs delivery and represents a new avenue to the treatment of pancreatic carcinoma by overcoming extracellular matrix and drug reflux barriers.
Geometric Control of Domain Structure Stability in Ferroelectric Nanotubes
Authors: Ross Aiden , Zhuang Shihao , Zhang Mojue , Hu Jia‐Mian 
Published: May 2022

AbstractFerroelectric nanotubes offer intriguing opportunities for stabilizing exotic polarization domains and achieving new or enhanced functionalities by tailoring the complex interplay among the geometry, surface effects, crystal symmetry, and more. Here, phase‐field simulations to predict the room‐temperature equilibrium polarization domain structure in (001)pc PbZr0.52Ti0.48O3 (PZT) nanotubes are used (pseudocubic (pc)). The simulations incorporate the influence of surface‐tension‐induced strains, which have been ignored in existing computational studies. It is found that (001)pc PZT nanotubes can host a unique class of topological polarization domain structures comprising non‐planar flux‐closures and anti‐flux‐closures that are inaccessible with ferroelectrics of planar geometry (e.g., thin‐films, nanodots). It is shown that surface‐tension‐induced strain is significantly enhanced in thin‐walled nanotubes and thereby can lead to noticeable modulation of the flux closures. Domain stability map as a function of the nanotube wall thickness and height is established. The results provide a basis for geometrical engineering of domain structures and associated functional (e.g., piezoelectric, electrocaloric) responses in ferroelectric nanotubes.
Adenosquamous carcinoma of gallbladder associated with biliopancreatic maljunction and Todani 1c choledochal cyst: A case report
Authors: Tidjane Anisse , Boudjenan‐Serradj Nabil , Khalifa Samia , Ikhlef Nacim , Bengueddach Aicha , Larbi Hakim , Meharzi Sif el islam , Tabeti Benali 
Published: May 2022

AbstractGallbladder cancer is the fifth most frequent women cancer in Algeria. Squamous‐cell and adenosquamous carcinomas are the rarest histological type of this cancer and represent less than 7%. Malformation of the bile ducts such as a choledochal cyst or a biliopancreatic maljunction are risk factors for this cancer. This manuscript reports a rare case of an 82‐year‐old woman operated on for an adenosquamous carcinoma of the gallbladder associated with a bile duct cyst and a biliopancreatic junction abnormality. Aggressive surgery was performed combined with adjuvant oral chemotherapy. Twenty‐nine months of recurrence‐free survival was achieved by this patient suffering from this aggressive and rare form of gallbladder cancer.
Thermally stable poly(urethane‐imide)s with enhanced hydrophilicity for waterproof‐breathable textile coatings
Authors: Meena Mahipal , Kerketta Anjlina , Tripathi Manorama , Roy Prasun , Jacob Josemon 
Published: May 2022

AbstractThermally stable, waterproof, hydrophilic, breathable poly(urethane‐imide) (PUI) films were prepared as a potential replacement for the existing polyurethanes (PU) with a lower degree of thermal stability for waterproof breathable clothing. Hydrophilic PUI films were prepared by reacting 4,4′‐ diphenylmethane diisocyanate (MDI), polyethylene glycol (PEG‐1500), and pyromellitic dianhydride (PMDA), with increasing hard segment (46%–61%) and compared with polyurethane films with similar PEG content. The breathability of PUI film is significantly higher than the PU film (~20%). Interestingly, despite the high degree of water sorption, the PUI films exhibited higher waterproofness (~85%) than the PU, which has been attributed to the presence of imide functionalities. The thermal stability of PUI was higher (Tmax1 ~ 420°C, Tmax2 ~ 600°C and char yield 21%) than the analogous PU (Tmax1 ~ 360°C, Tmax2 ~ 420°C, and char yield 6%). The waterproofness, water contact angle, and glass transition temperature are found to increase with increasing imide content, while the water sorption capacity and breathability decrease. The developed PUI coated fabric withstood hydrostatic pressure of ~3000 mbar, with a WVTR of 1200 g m−2 24 h−1, bestowing it excellent candidature as a waterproof breathable fabric.
Supramolecular Nanofibers Formed by Enzyme‐Instructed Self‐Assembly for SKBR‐3 Cell Selective Inhibition
Authors: Wang Shijiang , Ma Yan , Ma Changsheng , Liu Kai , Huo Zhijun , Shang Yuna 
Published: May 2022

AbstractCell‐targeted peptides are recommended for precision cancer treatment due to their comparable targeting properties, small molecular size, and good biocompatibility. However, unpredictable bioactivity, low penetration rate and poor stability greatly limit its efficacy. Supramolecular self‐assembly based on synthetic peptide has great potential to solve related problems and achieve better therapeutic effects. Herein, we report and compare the effects of two different assembly pathway, heating‐cooling, and enzyme instruction, on the penetrability of SKBR‐3 cell targeted peptides. It was found that enzyme‐instructed self‐assembly (EISA) resulted in hydrogels composed of uniform supramolecular nanofibers, whereas heating‐cooling resulted in solutions and precipitations composed of slightly different nanoparticles. The nanofibers formed by EISA showed enhanced cellular uptake (2.54 μM), which was significantly higher than the 1.06 μM of the nanoparticles formed by temperature regulation. Thus, EISA is a promising strategy to improve the cell penetration rate of targeted peptides and could provide a better solution for precision cancer treatment.
Active fault detection and isolation in linear time‐invariant systems: A geometric approach
Authors: Flores‐León Héctor , Begovich Ofelia , Ruiz‐León Javier , Ramírez‐Treviño Antonio 
Published: May 2022

AbstractIn this work, a novel approach on active fault detection and isolation for linear time‐invariant systems, named forced diagnosability, is proposed. This approach computes a continuous state feedback law to render a fault diagnosable, even when it cannot be diagnosed by using passive diagnosis methods. To do that, this work derives novel geometric relationships between unobservability and
‐invariant subspaces that, under certain conditions, guarantee the existence of such state feedback law. The objective of the state feedback law is to force all the faults, except the one required to be diagnosed, named
, to reside in an unobservability subspace. This effectively decouples the effect of
on the system output, from the effect of the other faults, allowing the design of a residual generator to detect and isolate the desired fault. The proposed state feedback law continuously forces diagnosability, and it can be computed in polynomial time. This avoids testing faults only at fixed time intervals and solving complex optimization problems required in other active diagnosis approaches. A numerical example is presented to illustrate the efficiency of the proposed approach.
Production of afucosylated antibodies in CHO cells by coexpression of an anti‐FUT8 intrabody
Authors: Joubert Simon , Guimond Julie , Perret Sylvie , Malenfant Félix , Elahi S. Mehdy , Marcil Anne , Parat Marie , Gilbert Michel , Lenferink Anne E.G. , Baardsnes Jason , Durocher Yves 
Published: May 2022

AbstractSome effector functions prompted by immunoglobulin G (IgG) antibodies, such as antibody‐dependent cell‐mediated cytotoxicity (ADCC), strongly depend on the N‐glycans linked to asparagine 297 of the Fc region of the protein. A single α‐(1,6)‐fucosyltransferase (FUT8) is responsible for catalyzing the addition of an α‐1,6‐linked fucose residue to the first GlcNAc residue of the N‐linked glycans. Antibodies missing this core fucose show a significantly enhanced ADCC and increased antitumor activity, which could help reduce therapeutic dose requirement, potentially translating into reduced safety concerns and manufacturing costs. Several approaches have been developed to modify glycans and improve the biological functions of antibodies. Here, we demonstrate that expression of a membrane‐associated anti‐FUT8 intrabody engineered to reside in the endoplasmic reticulum and Golgi apparatus can efficiently reduce FUT8 activity and therefore the core‐fucosylation of the Fc N‐glycan of an antibody. IgG1‐producing CHO cells expressing the intrabody secrete antibodies with reduced core fucosylation as demonstrated by lectin blot analysis and UPLC‐HILIC glycan analysis. Cells engineered to inhibit directly and specifically alpha‐(1,6)‐fucosyltransferase activity allows for the production of g/L levels of IgGs with strongly enhanced ADCC effector function, for which the level of fucosylation can be selected. The quick and efficient method described here should have broad practical applicability for the development of next‐generation therapeutic antibodies with enhanced effector functions.
Application of digital technologies for sustainable product management in a circular economy: A review
Authors: Rusch Magdalena , Schöggl Josef‐Peter , Baumgartner Rupert J. 
Published: May 2022

AbstractDigital technologies (DTs), such as the Internet of Things, big data, artificial intelligence, or blockchain, are considered as enablers for a more sustainable and circular economy. So far, literature on these topics has mostly focused on specific DTs and subareas of sustainable product management (SPM). The aim of this paper is to provide a more comprehensive overview of current and potential examples of DT applications in SPM (e.g., product design/assessment, supply chain management, and business models). The collected examples (n = 146) were analyzed based on a systematic literature review, using quantitative and qualitative content analysis. Deductive and inductive analyses of the examples revealed the potential of DTs in terms of their usability along the product life cycle, their role as enablers for circular economy strategies and in specific SPM activities. DT application often entails only incremental improvements, for example, increased efficiency of existing processes, with more radical forms of improvement remaining relatively scarce. There is clear room for greater adoption and optimization of DTs, in various areas of SPM, so as to accelerate the transition towards a more sustainable and circular economy.
Dandelion‐like Nanospheres Synthesized by CoO@CuO Nanowire Arrays for High‐Performance Asymmetric Supercapacitors
Authors: Li Xiuzhen , Huang Weiguo , Zhong Yuxue , Liao Leiping , Cheng Yujun , Zheng Kun , Liu Jingquan 
Published: May 2022

AbstractRecently, three‐dimensional‐structure materials have attracted enormous attention in energy‐storage fields on account of their excellent electrochemical performance. In this study, hierarchical nanospheres consisting of mesoporous CoO@CuO nanowires on a three‐dimensional conductive Ni foam are prepared by a one‐step hydrothermal method combined with a subsequent annealing process. Compared to CoO or CuO alone, the as‐obtained CoO@CuO/Ni hybrid nanowires show good electronic conductivity owning to the abundant existence of O vacancies in them. In a three‐electrode system, the area capacitance of the prepared CoO@CuO/Ni electrode reaches 2.94 F cm−2 (1.32 C cm−2) at 1 mA cm−2, and the CoO@CuO/Ni electrode presents an outstanding cycle performance. Moreover, a CoO@CuO/Ni//AC ASC asymmetric supercapacitor is fabricated and found to display a high energy density of 20.22 Wh kg−1 at 800 W kg−1. Hence, this novel CoO@CuO/Ni hybrid nanowires with excellent electrochemical properties shows outstanding potential in the practical application of high‐energy storage devices.
Electrochemical Formation and Reactivity of a Mn‐Peroxo Complex Bearing an Amido N5 Ligand
Authors: Massie Allyssa A. , Kostopoulos Nikolaos , Grotemeyer Elizabeth N. , Noël Jean‐Marc , Jackson Timothy A. , Anxolabéhère‐Mallart Elodie 
Published: May 2022

AbstractHerein we report the electrochemical generation of a mononuclear MnIII(OO) (peroxo) complex supported on a dpaq ligand (dpaq=2‐(bis(pyridin‐2‐ylmethyl)amino)‐N‐(quinolin‐8‐yl)acetamide) for the first time, and its reactivity in N,N‐dimethylformamide. The formation of the MnIII(dpaq)(OO) complex is probed by low temperature electronic absorption spectro‐electrochemistry experiments. An analysis of the reduction of the MnIII(dpaq)(OO) complex is carried out combining cyclic voltammetry and simulations. The involvement of a MnII(dpaq)(OOH) complex is proposed based on CV data and is corroborated by DFT computations.
Quantum Efficiency of Electrochemiluminescence Generation by Tris(2,2’‐bipyridine)ruthenium(II) and Tri‐n‐propylamine Revisited from a Kinetic Reaction Model
Authors: Ding Jialian , Zhou Ping , Su Bin 
Published: May 2022

AbstractElectrochemiluminescence quantum efficiency (ECL‐QE) is an important parameter to evaluate the energy conversion ability of luminophores and analytical sensitivity of corresponding ECL systems. Herein, taking tris(2,2’‐bipyridine)ruthenium(II) (Ru(bpy)32+) and tri‐n‐propylamine (TPrA) coreactant system as an example, the ECL‐QE was evaluated in terms of a kinetic reaction model, in which Ru(bpy)33+ was considered to be the key intermediate in a reaction scheme consisting of competitive oxidative reduction and catalytic reaction routes. It was calculated as the product of electrochemical excitation efficiency (ηex) and light emission efficiency (i. e., photoluminescence quantum yield, PLQY). We used finite element simulations to examine the variation of ηex with the electrode material, applied potential, concentration and distance from the electrode surface. ηex was found to be largely determined by the electrochemical oxidation rate of TPrA that varied by several orders of magnitude with the electrode material. The estimation of ECL‐QE helped in selecting the appropriate conditions for efficient ECL generation and sensitive analysis.
Prozessmodule schneller und flexibler integrieren
Authors: Maurmaier Mathias 
Published: May 2022

AbstractAus Sicht der Automatisierung ist die schnelle und flexible Einbindung von Prozessmodulen und Package Units in vorhandene Automatisierungsstrukturen in der Prozessindustrie immer noch herausfordernd. Abhilfe schafft das MTP‐Konzept (Module‐Type‐Package‐Konzept), das seit dem vergangenen Herbst von PI gehostet wird.
Neue Wege für den technischen Einkauf
Authors: Schulze Thorsten , Gandert Etwina 
Published: May 2022

AbstractAutomation24 bietet konfigurierbare und lagerhaltige Produkte der Bereiche Fabrik‐ und Prozessautomation an. Im Interview mit CITplus beantwortet der Geschäftsführer, Thorsten Schulze, Fragen für die Nutzer des Online‐Shops.
Ein Fünftel Energie in der Belebung eingespart
Authors: Sienk Thorsten 
Published: May 2022

AbstractDie Investition in neue Gebläsetechnik für die Belebung in der KLäranlage Berghei macht sich für den Erftverband schnell bezahlt. Bei etwa 20% weniger Stromkosten war der Return on Investment in gerade einmal drei Jahren erreicht.
Intelligente Pumpensysteme
Authors: Pastow Moritz 
Published: May 2022

AbstractDas Pumpen‐überwachungssystem von Lewa macht Pumpen Smart‐Factory‐ready: Neben dem Erkennen von Störungen und Prozessabweichungen liefert Smart Monitoring auch wichtige Kennzahlen zur wirtschaftlichen Bewertung der Anlage. Lewa unterstützt zusätzlich mit Betriebsanalysen der Laufzeitdaten. Dabei liegt die Datenhoheit immer beim Betreiber.
Single‐cell profiling reveals novel cellular heterogeneity of monocytes during Hymenoptera venom allergy
Authors: Chao Wen‐Cheng , Liao Wen‐Ting , Wang Jing‐Rong , Sung Hsiao‐Ni , Chen Hsin‐Hua , Lin Fang‐Ping , Huang Jou‐Yu , Liu Kuan‐Ting , Ko Tai‐Ming 
Published: May 2022

AbstractBackgroundHymenoptera stings can induce dysregulated inflammation and immediate hypersensitivity reactions including anaphylaxis. However, the molecular mechanisms underlying peripheral immune responses during Hymenoptera venom allergy (HVA) remain elusive.MethodsHere we determined the single‐cell transcriptomic profiling from highly heterogeneous peripheral blood cells in patients with HVA through unbiased single‐cell RNA sequencing and multiple models of computational analyses.ResultsThrough clustering analysis by uniform manifold approximation and projection, we revealed an increased number of monocytes in the acute phase and identified innate immune responses, leukocyte activation, and cellular detoxification as the main involved biological processes. We used filter analysis to identify that CLU that encodes clusterin was highly expressed in monocytes, and the co‐expressed genes of CLU further supported the key role of monocyte. We further used pseudo‐temporal ordering of cells and scRNA velocity analysis to delineate disease‐associated monocyte lineages and states in patients with HVA.ConclusionsOur comprehensive molecular profiling of blood samples from patients with HVA revealed previously unknown molecular changes, providing important insights into the mechanism of venom allergy and potential therapeutic targets.
The long‐term impact of alveolar ridge preservation with xenograft bone mineral on peri‐implant health after 5 years in function: A retrospective cohort study of 108 patients assessed clinically and radiologically
Authors: Sayardoust Shariel , Norstedt Wilhelm , Shah Furqan A. 
Published: May 2022

AbstractObjectivesWhen teeth are lost, dental implants contribute to improved oral function and quality of life. Limitations in dental implant placement arising from poor bone anatomy may be circumvented via alveolar ridge preservation (ARP). The aim is to evaluate the long‐term impact of ARP on peri‐implant health and the relationship with common risk indicators such as smoking and history of periodontitis.Materials and MethodsOne hundred and eight patients were enrolled in this retrospective cohort study with 308 implants. Of these, ∼41% were placed in bone sites that had previously received ARP with deproteinized bovine bone mineral xenograft. Association between baseline variables: ARP, age, gender, number of implants per patient, anatomical site, smoking, and previous history of grade III/IV periodontitis, and outcome variables: mucositis, peri‐implantitis, implant loss, full‐mouth plaque score (FMPS), full‐mouth bleeding score, and marginal bone loss (MBL) was evaluated using both univariate and multivariate models.ResultsAfter 5 years, the overall survival rate was 93.7%. The occurrence of peri‐implantitis was 21.3% and the extent of MBL was ~2.2 mm. Both peri‐implantitis occurrence and MBL were comparable between ARP+ and ARP−. Smoking is associated with higher FMPS and MBL.ConclusionsThe findings indicate that peri‐implant health can be maintained around dental implants for up to 5 years in ARP+ sites using Bio‐Oss®. Smoking is a major risk indicator for peri‐implantitis, whereas the association between history of periodontitis and the risk of peri‐implantitis, based on this specific, well‐maintained cohort and the specific implants used, remains inconclusive.
Investigating Molecular Transformation Processes of Biodiesel Components During Long‐Term Storage Via High‐Resolution Mass Spectrometry
Authors: Hamacher David , Schrader Wolfgang 
Published: May 2022

AbstractBiodiesel is an important building block in renewable energy transformation. The main issue is that during storage biodiesel will undergo transformation processes that can lead to molecular changes, which then can cause applicational problems such as severe motor damage. To prevent this, a detailed understanding of the involved molecules and the emerging aging products is necessary. Biodiesel samples were stored for up to 12 months to monitor molecular changes, and all mixtures were investigated by using ultrahigh‐resolution mass spectrometry (HRMS) with electrospray ionization (ESI). The data revealed that during storage large numbers of oxygen atoms were incorporated into the fatty acid methyl esters (FAMEs). This process was dominant for the first quarter of aging but then became overshadowed by dimerization of oxygenated FAMEs. This means that there are two main pathways for aging in biodiesel: polyoxygenation and oligomerization. These findings greatly pin down the possible causes for sedimentation giving a solid foundation for aging inhibition development.