bluuebunny/crossref_metadata_2025_split huggingface dataset:
Soil salt distribution and cotton growth under mulched drip irrigation with soil moisture regulation in southern Xinjiang,China
Authors: Pingru He , Jingang Li , Shuang’en Yu , fucang Zhang , Tao Ma , Jihui Ding , Kaiwen Chen , Shuaishuai Guo , Suhang Peng 
Published: December 2022

Abstract
Aims
Water deficiency together with soil salinization have been seriously restricting the sustainable agricultural in southern Xinjiang, China for a long time. Optimal soil moisture regulation contributes to the amelioration of soil water and salinity for crops, which is favorable for plants production.
Methods
The field experiment with five soil water lower limit levels (85% FC (T1), 75% FC (T2), 65% FC (T3), 55% FC (T4) and 45% FC (T5), where FC is the field capacity) was conducted in southern Xinjiang to investigate the responses of soil water-salt dynamics and the cotton performance to soil moisture regulation strategies.
Results
The results indicated that the humid perimeter of soil water and leaching range of soil salt increased with the decrease of soil moisture lower limit. Though more soil salt was leached out for T5 treatment at flowering stage, soil salinity increased again at boll setting stage owing to the long irrigation interval. Soil salt accumulated in 0-100 cm after cotton harvest, and the accumulation amount followed T3 > T5 > T1 > T2 > T4. Moreover, with the decline of soil moisture lower limit, both the plant height and nitrogen uptake decreased significantly, while the shoot root ratio increased. Compared with the yield (7233.2 kg·hm-2) and water use efficiency (WUE, 1.27 kg·hm-2) of T1 treatment, the yield for T2 treatment only decreased by 1.21%, while the WUE increased by 10.24%.
Conclusion
The soil moisture lower limit of 75% FC was recommended for cotton cultivation in southern Xinjiang, China.
Towards a platform quantitative systems pharmacology (QSP) model for preclinical to clinical translation of antibody drug conjugates (ADCs)
Authors: Scheuher Bruna , Ghusinga Khem Raj , McGirr Kimiko , Nowak Maksymilian , Panday Sheetal , Apgar Joshua , Subramanian Kalyanasundaram , Betts Alison 
Published: December 2022

Abstract
A next generation multiscale quantitative systems pharmacology (QSP) model for antibody drug conjugates (ADCs) is presented, for preclinical to clinical translation of ADC efficacy. Two HER2 ADCs (trastuzumab-DM1 and trastuzumab-DXd) were used for model development, calibration, and validation. The model integrates drug specific experimental data including in vitro cellular disposition data, pharmacokinetic (PK) and tumor growth inhibition (TGI) data for T-DM1 and T-DXd, as well as system specific data such as properties of HER2, tumor growth rates, and volumes. The model incorporates mechanistic detail at the intracellular level, to account for different mechanisms of ADC processing and payload release. It describes the disposition of the ADC, antibody, and payload inside and outside of the tumor, including binding to off-tumor, on-target sinks. The resulting multiscale PK model predicts plasma and tumor concentrations of ADC and payload. Tumor payload concentrations predicted by the model were linked to a TGI model and used to describe responses following ADC administration to xenograft mice. The model was translated to humans and virtual clinical trial simulations were performed that successfully predicted progression free survival response for T-DM1 and T-DXd for the treatment of HER2+ metastatic breast cancer, including differential efficacy based upon HER2 expression status. In conclusion, the presented model is a step toward a platform QSP model and strategy for ADCs, integrating multiple types of data and knowledge to predict ADC efficacy. The model has potential application to facilitate ADC design, lead candidate selection, and clinical dosing schedule optimization.
Immune-related adverse events after immune checkpoint inhibitor exposure in adult cancer patients with pre-existing autoimmune diseases
Authors: Machado Antonio Pizuorno , Shatila Malek , Liu Cynthia , Wang Jianbo , Altan Mehmet , Zhang Hao Chi , Thomas Anusha , Wang Yinghong 
Published: December 2022

Abstract
Purpose
Immune checkpoint inhibitor (ICI) therapy can predispose patients to immune-related adverse events (irAEs) and autoimmune disease (AD) flare-ups, but the characteristics of irAEs among patients with pre-existing ADs are largely unknown. We conducted this study to determine the clinical courses, irAEs, AD flares, treatment, and outcomes of patients with AD on ICIs.
Methods
This was a retrospective study of adult cancer patients at a large cancer center who were diagnosed with ADs before undergoing ICI therapy. Patients’ clinical courses, complications, treatments, and outcomes related to both ADs flares and irAEs were collected and analyzed.
Results
The study included 197 patients. Most (55.4%) were women. Melanoma comprised the highest proportion (28.4%) of malignancies, and most (83.8%) patients received PD-1/PD-L1 inhibitors. Fifty (25.3%) patients developed a new irAE after starting ICI therapy, while 29 (14.7%) patients had an AD flare-up. Patients with inflammatory bowel disease had the highest incidence of AD flare-ups (31.7%), while patients with Hashimoto hypothyroidism had the highest incidence of new irAEs (39.2%). Patients with inflammatory bowel disease had more severe adverse events. In our cohort, patients with a new diagnosis of irAE were treated with immunosuppressive therapy. AD flares were managed similarly. With regard to irAE manifestations, the most common presentations were colitis (24 [12.1%] patients), hepatic transaminase elevations (8 [4%] patients), and pneumonitis (7 [3.5%] patients).
Conclusion
Our findings suggest that patients with gastrointestinal and rheumatologic ADs had a higher incidence of AD flare-ups, while patients with Hashimoto hypothyroidism and neurologic ADs had a higher incidence of new irAEs. Patients with prior ADs experiencing flare-ups or new irAEs after ICI therapy tend to require aggressive immunosuppressive treatment. Thorough evaluation of baseline disease status, appropriate medical management before ICI therapy, and early recognition of inflammatory exacerbation may help ensure long-term success in treating and improving outcomes in these patients.
Acquisition of tacit knowledge to enhance economic competitiveness: An empirical validation by Cosine distance
Authors: Aubin Amanzou Nogbou Andetchi 
Published: December 2022

AbstractKnowledge is the core of economic development because it has an increasing return to scale. It has two forms: explicit and tacit. It is more important to collect tacit knowledge because it would lead to the creation of new innovations. Unfortunately, the acquisition of tacit knowledge is costly because it is difficult to collect using investments in research and development and/or investments in education. Economists advocated three theories for ease of acquisition of tacit knowledge: the theory of learning regions, the theory of the communities of practices, and the theory of knowledge enablers. We did an empirical analysis of these theories by using cosine distance. The data have been collected during the study of the production of a local food originating from Côte d’Ivoire called “ Attiéké”. The results showed that the knowledge is different from one region to another and negatively correlates with geographical distance. The community of practice goes beyond nativity and is linked to training. The knowledge enabler is less efficient when he is far from the geographical area of original tacit knowledge. So, we recommend the Cosine Distance as a tool for decision-making in knowledge economics because it allows the arrangement of activities to collect tacit knowledge more efficiently.
Explaining biological differences between men and women by gendered mechanisms
Authors: Colineaux Hélène , Neufcourt Lola , Delpierre Cyrille , Kelly-Irving Michelle , Lepage Benoit 
Published: December 2022

Abstract
Background. The principal aim of this study was to explore if biological differences between men and women can be explained by gendered mechanisms.
Methods. We used data from the 1958 National Child Development Study, including all the living subjects of the cohort at the outcome collection wave (44-45 years). We explored several biomarkers as outcomes: systolic blood pressure, triglycerides, LDL cholesterol, HbA1c, CRP, and cortisol. Three conceptualizations of gender have been used to define methodological strategies: (a) Gender as an individual characteristic; (b) Gender as an effect of birth sex on socio-behavioural characteristics; (c) Gender as an interaction between birth sex and the social environment, here the early-life social environment. We estimated the total effect of sex and the proportion of total effect of birth sex eliminated by gender, measured by 3 different ways according to these 3 concepts, using g-computation.
Results. The average level of each biomarker was significantly different according to birth sex, higher in men for cardiometabolic biomarkers and higher in women for inflammatory and neuroendocrine biomarkers. The sizes of the differences were always smaller than one standard deviation but were larger than differences due to early-life deprivation, except for CRP. We observed gender mechanisms underlying these differences between men and women, even if the mediation effects were rarely statistically significant. These mechanisms were of three kinds: (1) mediation by socio-behavioural characteristics; (2) attenuation by gendered mechanisms; (3) interaction with early social environment. Indeed, we observed that being born into a deprived rather than non-deprived family increased metabolic and inflammatory biomarkers levels more strongly in females than in males.
Conclusions. The biological differences between men and women seem to not be purely explained by biological mechanisms. The exploration of gender mechanisms opens new perspectives, in terms of methodology, understanding and potential applications.
Association of quantitative analysis of intratumoral reduced E-cadherin expression with lymph node metastasis and prognosis in patients with breast cancer
Authors: Meng Xiangyue , Morita Michi , Kuba Sayaka , Hayashi Hiroko , Otsubo Ryota , Matsumoto Megumi , Yamanouchi Kosho , Kobayashi Kazuma , Soyama Akihiko , Hidaka Masaaki , Kanetaka Kengo , Nagayasu Takeshi , Eguchi Susumu 
Published: December 2022

Abstract
Loss of E-cadherin expression is a poor prognostic factor in patients with breast cancer. Breast cancer cells co-cultured with adipocytes reportedly promote E-cadherin attenuation and tumor progression. The current study aimed to investigate the association of reduced E-cadherin expression with adipose tissue invasion (ATI) and prognosis in breast cancer. Surgical specimens were collected from 188 women with invasive ductal carcinoma of the breast who had undergone surgery without neoadjuvant treatment. We compared E-cadherin expression in ATI and invasive front (IF) using immunohistochemistry with ImageJ. Reduced E-cadherin expression was detected not only in the ATI area but also in IF, and the degree of reduced E-cadherin expression was positively correlated with both areas. E-cadherin expression was reduced in patients with lymph node metastasis compared to those without, and reduced E-cadherin expression was an independent factor associated with lymph node metastasis, and poor recurrence-free survival than those without. We concluded that E-cadherin expression is reduced not only in the ATI area, but also at the invasive front of the tumor. Reduced E-cadherin expression is a clear prognostic factor for breast cancer. Hence, future research is warranted for establishing an objective and quantitative E-cadherin staining assay that will allow clinical use of E-cadherin as a prognostic factor.
Theory of sigma bond resonance in flat boron materials
Authors: Qiu Lu , Zhang Xiuyun , Kong Xiao , Mitchell Izaac , Yan Tianying , Kim Sung Youb , Yakobson Boris , Ding Feng 
Published: December 2022

Abstract
In chemistry, theory of aromaticity and π bond resonance plays a central role in intuitively understanding the stability and properties of organic molecules. Here we present an analogue theory for σ bond resonance in flat boron materials, which allows us to determine the distribution of two-center two-electron and three-center two-electron bonds without quantum calculations. Based on this theory, three rules are proposed to draw the Kekulé-like bonding configurations for flat boron materials and to explore their properties intuitively. As an application of this theory, the mystery of why neutral borophene with ~ 1/9 hole has the highest stability and the effect of charge doping on borophene’s optimal hole concentration are understood with the assumption of σ and π orbital occupation balance. Like the aromaticity theory for carbon materials, this theory greatly deepens our understanding on boron materials and paves the way for the rational design of various boron-based materials.
Den Lücken in der zu Geschichte geronnenen Vergangenheit nachspüren
Authors: Gimplinger Martina 
Published: December 2022

When Even The
Neunzig Minuten lang liegt der erratische, metallene Gegenstand starr und still vor uns auf der Bühne. Als wäre er dem Ort, dem er einmal angehörte, und der Verwendung, die man ihm einmal zugeschrieben hatte, entrissen worden. Seine feste, stählerne Materialität lässt ihn viele Jahre überdauern, selbst in dem jetzt abgenutzten, verbogenen, verrosteten Zustand. Die Wölbung, die sein fester Metallkörper aufweist, verleiht ihm etwas Bewegliches. Sie scheint von einer vergangenen Dynamik zu zeugen, die im Widerspruch zur offensichtlichen Schwere und Unbeweglichkeit des Materials steht. [...]
Zur Resistenz von Theater im Medienzeitalter
Authors: Kotte Andreas 
Published: December 2022

Worauf gründet die Gelassenheit von Theater angesichts von Digitalisierung und Medienpräsenz? Wie lässt sie sich erforschen? Danach fragt dieses Resümee eines theaterwissenschaftlichen Konzepts.
Nach zwei Jahren Pandemie und unzähligen beherzten Versuchen, Theatersituationen zu schaffen, fast oder ganz ohne ein Publikum, das sich mit den Agierenden zur gleichen Zeit am gleichen Ort trifft, wird nun die Aufarbeitung dessen erfolgen, was trotzdem gut funktioniert hat. Einige der medialen Versuche werden weitere anregen. Sie werden das riesige Spektrum von Theater erneut als „glutton“ ausweisen, als Vielfraß, der sich mit stoischer Ruhe auch Mediales einverleibt. Die hauptsächliche Reaktion wird aber ein Aufatmen sein, endlich wieder das, was man die Kopräsenz von Agierenden und Schauenden genannt hat, sinnlich auskosten zukönnen. In der gegenwärtigen liminalen Phase, die als Rückkehr zu alter Normalität, aber auch als ein Neubeginn gedeutet werden kann, erscheint es angemessen, über das Wechselverhältnis von Theater und elektronischen Medien noch einmal nachzudenken.
Analyzing Grammatical and Lexical Cohesion in A Legendary Short Story
Authors: Noprival Noprival , Alfian Alfian , Soma Robi 
Published: December 2022

Analyzing Grammatical and Lexical Cohesion in A Legendary Short Story Noprival Sekolah Tinggi Ilmu Kesehatan Harapan Ibu Jambi, Jambi, Indonesiae-mail: noprival@gmail.com (corresponding author) Alfian Universitas Islam Negeri Sulthan Thaha Saifuddin Jambi, Jambi, Indonesiae-mail: alfian@uinjambi.ac.id Robi SomaUniversitas Jambi, Jambi, Indonesiae-mail: robisoma858@unja.ac.id Abstract:Despite the existence of many studies on cohesion in discourse, little scholarly work reports grammatical and lexical cohesion in a short story. To fill this gap, the present study investigates these two aspects of cohesion in a legendary short story entitled “After Twenty Years.” Halliday and Hasan’s (1976) theoretical framework of cohesion was used to guide the current study. We applied textual analysis as the appropriate approach to find out grammatical and lexical cohesion within the forms of text. The findings in the grammatical cohesions showed that reference had the highest frequency of the total cohesive devices. Also, under grammatical cohesion, conjunctions are found to exist. However, other aspects were not found within this short story, including substitution and ellipsis. On the other hand, repetition was dominantly used lexically among other aspects of lexical cohesion and sequentially followed by repetitions, hyponyms, synonyms, and antonyms. Only one aspect of lexical cohesion, the meronym, was not found. The overall results of the research indicated that the short story was a coherent discourse because both grammatical and lexical cohesion exist properly.
Revisiting the motives for hydroinformatics
Authors: Jonoski A. 
Published: December 2022

Abstract
Since Mike Abbott established hydroinformatics about 30 years ago, the field has been characterized by tremendous growth in both research and practice. With its natural dependence on developments in information and communication technologies, the expansion and diversity of hydroinformatics concepts and applications have hardly been surprising. Such developments have brought some issues of concern within the hydroinformatics community, mainly associated with apparent loss of some foundational principles. This chapter attempts to clarify the current situation by revisiting the main motivations for hydroinformatics, as originally proposed and later developed by Abbott. It also re-introduces and re-interprets the main aspects of the field, with the hope that such a re-interpretation will be useful for the future growth and development of the subject. Hydroinformatics originated as an engineering discipline, specifically linked to hydraulic engineering and to the development and use of numerical models from within the field of computational hydraulics. This initiated the central idea that modelling in hydroinformatics is motivated by applications in the real world. The union of fourth-generation modelling systems with artificial intelligence, was originally regarded as being the essence of hydroinformatics. The initial emphasis of the subject was on developing models of our natural aquatic environment and man-made water infrastructure that were more reliable, leading to improved support for decision making. As a consequence, improving model generation and application for decision support became central, and the field of hydroinformatics was established as a technology for enabling transparent knowledge creation, mobilization and sharing among different stakeholders participating in water- and environmental decision making. Aiming at transforming decision-making processes (and not only supporting existing ones), hydroinformatics identified the Internet as the key platform for introducing environments that would enable the conjunctive use of different ‘knowledges’ (scientific, as well as social/cultural/narrative knowledge). These last aspects are ongoing motivations for hydroinformatics to continue its development as a technology with the responsibilities of caring for the aquatic environment and improving human well-being.
Application of isotopic tools to understand the hydrological processes and groundwater dynamics of Mianwali area-Punjab, Pakistan
Authors: Ghaffar Abdul , Iqbal Naveed 
Published: December 2022

AbstractThe study was conducted to investigate the hydrological system of ‘Mianwali’ area, which comprises an alluvium aquifer. Groundwater dynamics including groundwater direction, velocity and recharge mechanism were investigated to assess the groundwater sources conservation in the area. Hydrological samples were collected and analyzed for stable isotopes (18O and 2H); radioisotopes (3H), chloroflourocarbons (CFCs) and groundwater real and filtration velocities measured to understand the groundwater dynamics. Isotopic data suggested a variant recharge mechanism due to localize impacts of canals, lake and river. Groundwater residence time, using Tracer Lump Parameter Model (LPM), and CFCs data suggest a very young water in the range of 14–59 years old. The real and filtration velocities of groundwater found to be 22.2 cm/day and 10.94 cm/day, respectively, in south-west direction and in-situ effective porosity of the aquifer was 49.3%. The hydraulic conductivity of the aquifer was estimated using grain size analysis that varies from 48 to 278 m/day with average value of 139 m/day.
principiologia da Lei 9099/95 a partir de uma interpretação baseada nos pensamentos de Jürgen Habermas e Robert Alexy
Authors: Silva Cândido Francisco Duarte dos Santos e 
Published: December 2022

O estudo em questão tem por objetivo analisar a Lei 9099/95, que instituiu os Juizados Especiais Cíveis na Justiça Estadual, no que diz respeito aos seus limites e potencialidades discutidos a partir da principiologia proposta pela citada Lei em um viés jurídico-filosófico. Observar-se-á para tanto a Teoria do Discurso enquanto arcabouço procedimental capaz de potencializar a observância na prática de uma justiça mais célere, simples, informal, econômica e baseada na oralidade. Para tanto aplicar-se-á a interpretação do pensamento de Jürgen Habermas e de Robert Alexy em conjunto a autores tradicionais do Direito com o objetivo de se avaliar se o pensamento dogmático se encontra superado ou ainda se apresenta como um entrave para que os princípios, que a Lei atribui a condição de Critérios Orientadores dos Juizados Especial Cíveis, sejam observados na realidade fática.
Insulin Signaling Pathway Model in Adipocyte Cells
Authors: Zarghami Reza , Sheibani Monir , Jalali-Farahani Farhang , Sadrai Sima 
Published: December 2022

Background:
Worldwide, type 2 diabetes mellitus (T2DM) is one of the most pervasive and fastgrowing
disorders, bringing long-term adverse effects. T2DM arises from pancreatic β-cells deficiency to produce
enough insulin or when the body cannot effectively use the insulin produced by such cells. Accordingly,
early diagnosis will decrease the long-term effects and high-healthcare costs of diabetes.

Objective:
The objective is developing an integrated mathematical model of the insulin signaling network based
on Brännmark's model, which can simulate the signaling events more comprehensively with the added key
components.

Methods:
In this study, a thorough mathematical model of the insulin signaling network was developed by expanding
the previously validated model and incorporating the glycogen synthesis module. Parameters (69 parameters)
of the integrated model were evaluated by a genetic algorithm by fitting the model predictions to
eighty percent of experimental data from the literature. Twenty percent of the experimental data were used to
evaluate the final optimized model.

Results:
The time-response curves indicate that the GS phosphorylation reaches its maximum in response to
10-7 M insulin after 4 min, while the maximum phosphorylated GSK3 is attained within ~50 min. The doseresponse
curves for the GSP and GSK3 of the insulin signaling intermediaries in response to the increased concentration
of insulin, after 10 min, in the input from 0-100 nM exhibits a decreasing trend, whereas an increasing
trend was observed for the GS and GSK3P. The GSK and GS phosphorylation sensitivity was enhanced by
increasing the initial insulin concentration level from 0.001 to 100 nM. However, the sensitivity of GSK3 to insulin
concentration changes (from 0.001 to 100 nM) was 3-fold higher than GS sensitivity.

Conclusion:
Considerably, the trends of all signaling components simulated by the expanded model shows high
compatibility with experimental data (R2 ≥ 0.9), which approves the accuracy of the proposed model. The proposed
mathematical model can be used in many biological systems and combined with the whole-body model
of the blood glucose regulation system for a better understanding of the causes and potential treatment of type 2
diabetes. Although, this model is not a complete description of insulin signaling, yet it can make profound contributions
to improvements regarding other important components and signaling branches such as epidermal
growth factor (EGF) signaling, as well as signaling in other cell types in the model structure of future works.