bluuebunny/crossref_metadata_2025_split huggingface dataset:
THE INFLUENCE OF VARIOUS CONCENTRATED CHERRY (MUNTINGIA CALABURA) EXTRACT IN PREVENTING LACTOBACILLUS ACIDOPHILUS IN VITRO
Authors: Nurhalisa Siti , Lestari Endang Sri , Wibisono Gunawan , Indraswari Darmawati Ayu 
Published: June 2022

Background: Dental caries is a multifactorial illness caused by bacteria. Lactobacillus acidophilus is one of the bacteria causing caries, where it continues the caries process. That is why the antibacterial agent is needed. A cherry (Muntingia calabura) is fruit having many benefits for health, which one of them is as an antibacterial agent. It contains flavonoid, tannin, alkaloid, and terpenoid, which can function as the antibacterial agent. Aim :The study aimed to determine the influence of cherry (Muntingia Calabura) extract in preventing the growth of L.acidophilus. Method: True experimental laboratory with a post-test only control group design and 24 samples. Cherries were extracted by using maceration. Then, the phytochemical test was conducted to discover antibacterial substances. The antibacterial test was done by using the dilution method to know Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC). Results: Minimum Inhibitory Concentration (MIC) could not be seen, and Minimum Bactericidal Concentration (MBC) showed that all concentration 6,25%, 12,5%, 25%, and 50% and positive control were able to kill a bacterium L. acidophilus. Conclusions: There is an influence of cherry extract on the grow
COMPARISON OF DURATION PLAYING DEFENSE OF THE ANCIENTS-2 VIDEO GAME WITH REACTION TIME
Authors: Hadi Yosua Arif , Supatmo Yuswo , Kusumaningrum Novi , Susanto Hardono 
Published: June 2022

Background: DotA-2 is the most popular MOBA video game, which ranks the second most sold on the steam platform. Reaction time as a physiological parameter to find out how quickly to respond to a stimulus. Some research states that video games can increase reaction time. Objective: To know the correlation of playing video game Defense of the Ancients-2 with the duration of reaction time. Method: The study used cross-sectional design. This study was conducted in the area of the Faculty of Medicine, Diponegoro University. In this study found 42 respondents participated. Score of reaction time is measured using a ruler dropped from the respondent's fingertips. Analysis using Shapiro-Wilk test and Pearson test. Results: There is significant relationship between playing a DotA-2 status and reaction time. The duration of playing DotA-2 video games to the reaction time there were significant differences between the 3 groups. Conclusion: There is a significant relationship between the status of playing video game DotA-2 with reaction time.
Physicochemical properties and some mineral concentration of milk samples from different animals and altitudes
Authors: Mohammed Mohammed Elimam Ahamed , Brima Eid Ibrahim , Alasidy Aaed , Qurishi Nasir , Algarni Moad , Alshehri Badria Mohammed Abdallah 
Published: June 2022

AbstractThis study investigated the effect of animal origin and altitude on some physicochemical properties of milk and on the concentration of some minerals. The studied parameters were pH, conductivity, specific gravity, moisture, ash, total dissolved solids (TDS), sodium, potassium, and calcium. The milk samples were collected from camels (8), goats (5), and sheep (6). The samples were obtained from two altitudes: 14 and 2,110 m above sea level. At the low altitude, the conductivity was significantly different between the milks of the three ruminants and the moisture, TDS, specific gravity, and calcium were significantly different between the camel and sheep milks. Regarding the animals living at the high altitude, the moisture, TDS, specific gravity, and the ash were significantly different between the camel and sheep milks and between the sheep and goat milks. Concerning the effect of altitude on the studied parameters of the milk, it had variable significant effects on the studied parameters according to the animal origin. The animal origin and the altitude had significant effects on the milk conductivity, ash, and specific gravity.
Toxicological evaluation of hydroethanol leaf extract ofPupalia lappacea(Linn.) Juss. (Amaranthaceae) in rodents
Authors: Abdullahi Murtala Akanji , Oyinloye Elijah Oladapo , Alabi Akinyinka , Aderinola Aderonke Adeyinka , Ogunjimi Luqman Opeyemi , Omoloye Adesina A. , Odusote Ayobami A. , Olusola Joseph O. , Adebayo Oluwatosin O. , Olooto Wasiu Eniola 
Published: June 2022

AbstractObjectivesSeveral studies have established the ethnobotanical benefits ofPupalia lappacea(PL) in laboratory animals without extensive toxicological evaluation of its safety profiles. Thus, an extensive toxicological investigation of sub-chronic oral administration of the hydroethanol leaf extract ofP. lappaceain rodents was carried out in this study.MethodsDifferent groups of rats were treated orally with the extract (10, 50 and 250 mg/kg) daily for 90 consecutive days. The control group received distilled water (10 mL/kg). After 90 days, some rats were left for additional 30 days without treatment for reversibility study. Blood and organs samples were collected for different evaluations at the end of study periods.ResultsThe extract decreased the bodyweights, feeding and water intakes in female rats. PL increased the weights of the liver and kidney in male rats. PL increased the red blood cell (RBC), packed cell volume (PCV), hemoglobin (Hb), triglycerides (TRIG), cholesterol and high density lipoprotein (HDL) contents in rats. PL (250 mg/kg) significantly reduced the sperm motility and serum testosterone level. Cyto-architectural distortions of the testes, liver and spleen were visible.ConclusionsThe findings showed thatP. lappaceais relatively safe at lower doses but cautions should be taken at higher dose.
Study of the pharmacokinetics of various drugs under conditions of antiorthostatic hypokinesia and the pharmacokinetics of acetaminophen under long-term spaceflight conditions
Authors: Polyakov Alexey V. , Svistunov Andrey A. , Kondratenko Svetlana N. , Kovachevich Irina V. , Repenkova Lyudmila G. , Savelyeva Marina I. , Shikh Evgenia V. , Badriddinova Lidiya Y. 
Published: June 2022

Abstract

Objectives
To study the pharmacokinetics and relative bioavailability of drugs of different chemical structure and pharmacological action under conditions simulating the effects of some factors of spaceflight, as well as the peculiarities of the pharmacokinetics of acetaminophen under long-term spaceflight conditions.

Methods
The pharmacokinetics of verapamil (n=8), propranolol (n=8), etacizine (n=9), furosemide (n=6), and acetaminophen (n=7) in healthy volunteers after a single oral administration under normal conditions (background) and under antiorthostatic hypokinesia (ANOH), the pharmacokinetics of acetaminophen in spaceflight members under normal ground conditions (background) (n=8) and under prolonged spaceflight conditions (SF) (n=5) were studied.

Results
The stay of volunteers under antiorthostatic hypokinesia had different effects on the pharmacokinetics and bioavailability of drugs: Compared to background, there was a decreasing trend in Vz for verapamil (−54 Δ%), furosemide (−20 Δ%), propranolol (−8 Δ%), and acetaminophen (−9 Δ%), but a statistically significant increase in Vz was found for etacizine (+39 Δ%); there was an increasing trend in Clt for propranolol (+13 Δ%) and acetaminophen (+16 Δ%), and a decreasing trend in Clt for etacizine, verapamil, and furosemide (−22, −23 and −9 Δ% respectively) in ANOH. The relative bioavailability of etacizine, verapamil, and furosemide in ANOH increased compared to background (+40, +23 and +13 Δ%, respectively), propranolol and acetaminophen decreased (−5 and −12 Δ% accordingly). The relative rate of absorption of etacizine and furosemide in ANOH decreased (−19 and −20 Δ%, respectively) while that of verapamil, propranolol, and acetaminophen increased (+42, +58 and +26 Δ%, respectively). A statistically significant decrease in AUC0-∞ (−57 Δ%), Cmax (−53 Δ%), relative bioavailability of acetaminophen (−52 Δ%) and a sharp increase in Clt (+147 Δ%), Tmax (+131 Δ%) as well as a trend towards a significant decrease in T1/2 (−53 Δ%), MRT (−36 Δ%) and a moderate increase in Vz (+24 Δ%) were found under control compared to background. Unidirectional changes in AUC0-∞, Clt, T1/2, MRT and relative bioavailability of acetaminophen, which are more pronounced in SF and opposite dynamics for Cmax, Tmax, Vz were found in ANOH and SP compared to background studies.

Conclusions
The data obtained allow recommending the studied drugs for rational pharmacotherapy in the possible development of cardiovascular disease in manned spaceflight.
Entrepreneurial Well-being: An Exploratory Study for Positive Entrepreneurship
Authors: Turnalar-Çetinkaya Neslihan , İslamoğlu Güler 
Published: June 2022

Abstract
Given the limited studies in the literature to understand entrepreneurial well-being, in this study, we aimed to answer the questions “what kind of resources does an entrepreneur need to experience a high level of well-being?” and “what would be the possible consequences of an entrepreneur’s well-being?” To elaborate the entrepreneurial well-being concept further, we conducted in-depth interviews with 20 male, married, and opportunity-driven entrepreneurs operating technology enterprises in Turkey. Based on the thematic analysis of the interviews, we ended up with six resources for their well-being (i.e., individual factors, family life, entrepreneurial success, network, the team, and investment) and five areas on which their well-being is impactful (i.e., individual, family, societal, employees, and business). Despite its limitations, our study contributes significantly to entrepreneurial well-being literature and paves the way for further research.
Osteopathic manipulative treatment use among family medicine residents in a teaching clinic
Authors: Caldwell Garrett , Zeng Leezanne , Kaufman Jennifer , Bates Joel 
Published: June 2022

Abstract

Context
Osteopathic Principles and Practice (OPP), including osteopathic manipulative treatment (OMT) is the core foundation of the education provided by osteopathic medical schools. Multiple studies performed over the past 25 years have demonstrated that a dwindling number of osteopathic physicians utilize OMT in their practice, despite 95% of osteopathic family physicians perceiving OMT as an effective treatment modality.

Objectives
The objective of this study is to quantify how often OMT is being performed by residents in an osteopathically recognized family medicine training clinic and to identify the perceived barriers to performing OMT.

Methods
Fifteen family medicine residents were given access to an anonymous written survey for three 2 week periods. The survey allowed them to input the total number of patient encounters for their half clinic day, the encounters in which OMT was perceived to be appropriate, the encounters in which OMT was performed, and the reasoning for encounters in which OMT was not performed. Surveys were collected anonymously, and data were input into a datasheet in which results were calculated.

Results
A total of 101 survey responses were collected for a total of 304 patient encounters. OMT was performed in 5/304 (1.6%) encounters, yet it was perceived to be appropriate in 60/304 (19.7%) encounters. The primary documented reason that OMT was deferred was due to time constraints (42/50 responses, or 70.0% of the encounters in which OMT was deemed appropriate).

Conclusions
This study highlights time as the main reason OMT is deferred by residents in a teaching clinic. This provides insight into potential interventions in a training clinic to increase the use of OMT by family medicine residents.
The dimension Dind of finite topological T
0-spaces
Authors: Georgiou Dimitrios N. , Hattori Yasunao , Megaritis Athanasios C. , Sereti Fotini 
Published: June 2022

Abstract
A. V. Arhangelskii introduced the dimension Dind and properties of this dimension have been studied for various classes of topological spaces. In this paper, we study this dimension for finite T
0-spaces. Especially, we prove that in the realm of finite T
0-spaces, Dind is less than or equal to the small inductive dimension ind, the large inductive dimension Ind and the covering dimension dim. We also study the “gaps” between Dind and the dimensions ind, Ind and dim, presenting various examples which shows these “gaps”. Moreover, in this field of spaces, we give characterizations of Dind, inserting the meaning of the maximal family of pairwise disjoint open sets, and study properties of this dimension.
Feasibility of High-Intensity Resistance Training Sessions in Cancer Survivors
Authors: Schlüter Kathrin , Schneider Justine , Rosenberger Friederike , Wiskemann Joachim 
Published: June 2022

Abstract
Schlüter, K, Schneider, J, Rosenberger, F, and Wiskemann, J. Feasibility of high-intensity resistance training sessions in cancer survivors. J Strength Cond Res 36(9): 2643–2652, 2022—Moderate-intensity resistance training (MIRT) is regarded as safe in cancer survivors (CS), but for high-intensity resistance training (HIRT), evidence is lacking. Hence, in the current exploratory analyses, single sessions of HIRT are compared with MIRT regarding safety and feasibility. Twenty-three of 24 included CS (14 breast and 10 prostate CS, 61.6 ± 9.5 years, body mass index 27.0 ± 4.3 kg·m−2, 6–52 weeks after end of primary therapy) started a 12-week resistance training (RT) with a daily undulating periodization model including HIRT (90% of 1 repetition maximum [1RM]) and MIRT (67% 1RM) sessions. Parameters of safety (adverse events [AEs] and training-related pain), feasibility (physical and mental exhaustion, sensation of effort, enjoyment, and dropout rate), and adherence were assessed. An alpha level of 0.05 was applied for analyses. Nineteen of 23 training starters (83%) completed all sessions. Fourteen minor AEs occurred. A significantly higher increase for physical exhaustion appeared in HIRT (p < 0.001). For 18% (HIRT) and 19% (MIRT) of the sessions, training-related pain was reported with no significant difference between intensities. In total, 34% of HIRT and 35% of MIRT sessions were perceived as overstraining or partly overstraining with no significant difference between intensities, but enjoyment (median and quartiles on a 1–7 scale) was high for both (HIRT = 5 [5;6] and MIRT = 5 [4,6]). Our analysis indicates that HIRT sessions do not differ from MIRT sessions concerning safety or feasibility, but training-related pain should be monitored. RT protocols incorporating high-intensity training loads can be applied safely in breast and prostate CS.
Movement Trajectory Control of an Intelligent Mobile Robot Controlled by Machine Vision
Authors: Sun Jumei , Chu Qin , Liu Shukai 
Published: June 2022

Abstract
Intelligent mobile robots can take up various repetitive labor tasks instead of humans, but with the increase in labor requirements, the requirements for the autonomous working ability of intelligent mobile robots have also increased. This research used machine vision to identify obstacles in the working environment; then, a plane model was constructed for the working environment of the intelligent mobile robot with the help of machine vision. The moving path was planned by the ant colony algorithm. The robot adopted the trajectory tracking control law to track the planned path to realize the autonomous movement of the intelligent mobile robot. Finally, experiments were carried out, and the trajectory control of the robot moving on the path planned by the ant colony algorithm was compared with that planned by the genetic algorithm. The results showed that the ant colony algorithm converged faster and planned a shorter path after stability; when the coordinates of the starting and end points of the planned path were (0.0 m, 2.5 m) and (5.0 m, 0.0 m), respectively, the turning point coordinates of the paths planned by the genetic and ant colony algorithms were (2.5 m, 2.0 m) and (3.5 m, 0.0 m), respectively; the robot had shorter movement trajectory, smaller deviation, and less movement time on the path planned by the ant colony algorithm than the genetic algorithm.
Renewable Energy Regulations in Indonesia and India: A Comparative Study on Legal Framework
Authors: Karim Ridoan , Ghazali Farahdilah , Ansari Abdul Haseeb 
Published: June 2022

Individually and collectively, climate change has become the international agenda due to global warming and unusual weather patterns. The International Renewable Energy Agency (IRENA) claims that the future world can only survive if the human civilisation takes a drastic turn towards renewable;e energy production. Besides, the pandemic COVID-19 has ventured us to revisit our behaviour towards the environment. Indonesia and India, being two giant economies, has promised under the Paris Climate Agreement to support the international agendas of climate change and sustainable development goals. Many countries have shown their commitment to lower their carbon emissions by using renewable energy sources significantly. Renewable energy generation opens a feasible door to attempts to combat climate change. This comparative analysis assesses the renewable energy laws and policies in Indonesia and India, as they work towards their climate change commitments (UNFCCC). This research operates within comparative qualitative methodological structures and uses secondary empirical sources. Building on similar and relative exposures, both the countries should benefit from each other and learn the legal and political implications to speed up the production of renewable energy and reduce greenhouse gas (GHG) emissions.
Non-thyroidal second primary malignancy in papillary thyroid cancer patients
Authors: Borges Duarte Diana , Benido Silva Vânia , Assunção Guilherme , Couto Carvalho André , Freitas Cláudia 
Published: June 2022

Introduction
The occurrence of non-thyroidal second primary malignancy (NTSPM) in patients with papillary thyroid cancer (PTC) is well documented, but epidemiological data are conflicting.

Objective
The aim of this study was to evaluate the incidence of NTSPM in a large series of patients with PTC and to assess its potential risk factors.

Methods
Single-center cohort study with retrospective data collection conducted on consecutive PTC patients diagnosed from 1988 to 2018 with a minimum follow-up time of 2 years. NTSPM was defined as any primary malignancy with histological confirmation occurring in an anatomical site other than the thyroid. According to the timing of occurrence, NTSPM were subdivided into anachronous, synchronous or metachronous (diagnosed >6 months before, within 6 months and >6 months after PTC diagnosis, respectively).

Results
We included 773 individuals (83.3% females), median age at PTC diagnosis was 47.0 (IQR: 37.0–58.0) years and median follow-up time was 9.9 (6.2–16.3) years. Incidence of NTSPM was 15.5% (n  = 120) and its standard incidence ratio (SIR) was higher when compared to the general population (SIR: 2.70). Family history of malignancy and younger age at diagnosis were associated respectively with 206 and 4% increased risk of developing metachronous neoplasia (HR: 2.06 (95% CI: 1.10–3.86) and 1.04 (95% CI: 1.02–1.05), respectively).

Conclusion
In our series, the occurrence of NTSPM was not uncommon and its incidence was higher compared to the general population. First-degree family history of malignancy was a strong risk factor for multiple primary malignancies.
Pet owners' feedback on psychological support service in an Italian veterinary hospital
Authors: Campigli Michela , Strizzolo Giulia , Furlanello Tommaso , Uccheddu Stefania 
Published: June 2022

Abstract
The emotional stress experienced by pet caregivers, induced by negative diagnoses, clinical problems, and/or long-term therapies should be taken into serious consideration by the veterinarians to prevent these individuals from the risk of experiencing incapability of dealing with the great burden and the eventual reduction of compliance. Understanding the client's affective state may enhance the veterinarian's empathic response and effective communication. To understand better the unmet needs of clients, we collected data on service requests at the clinic and emotions that caregivers felt in the veterinarian setting. Understanding these difficulties may represent a first step to initiate the development of a psychological intervention targeting problems experienced by the caregivers. Assuming these difficulties according to the service requested for the pet, the owners might be interested in psychological support provided directly by the veterinary hospital. Our survey showed that a large percentage of owners expressed feelings related to caregiving in the veterinary setting, irrespective of the type of assistance needed, including apparently easy procedures. At the same time, they expressed a strong intention to receive a professional support. However, the crucial role of the psychological support is still difficult to accept even when it can be perceived as a right choice.
Preventing Unraveling in Social Networks Gets Harder
Authors: Chitnis Rajesh , Fomin Fedor , Golovach Petr 
Published: June 2022

The behavior of users in social networks is often observed to be affected by the actions of their friends. Bhawalkar et al. (ICALP '12) introduced a formal mathematical model for user engagement in social networks where each individual derives a benefit proportional to the number of its friends which are engaged. Given a threshold degree k the equilibrium for this model is a maximal subgraph whose minimum degree is at least k. However the dropping out of individuals with degrees less than k might lead to a cascading effect of iterated withdrawals such that the size of equilibrium subgraph becomes very small. To overcome this some special vertices called "anchors" are introduced: these vertices need not have large degree. Bhawalkar et al. considered the Anchored k-Core problem: Given a graph G and integers b, k and p do there exist sets of vertices B, H such that B is a subset of H, size of B is at most b and size of H is at least p, and every vertex v which is in H but not in B has degree at least k in the induced subgraph G[H]. They showed that the problem is NP-hard for all k greater equal 2, and gave some inapproximability and fixed-parameter intractability results. In this paper we give improved hardness results for this problem. In particular we show that the Anchored k-Core problem is W[1]-hard parameterized by p, even for k=3. This improves the result of Bhawalkar et al. (who show W[2]-hardness parameterized by b) as our parameter is always bigger since p is greater equal than b. Then we answer a question of Bhawalkar et al. by showing that the Anchored k-Core problem remains NP-hard on planar graphs for all k greater equal 3, even if the maximum degree of the graph is k+2. Finally we show that the problem is FPT on planar graphs parameterized by b for all k greater equal 7.