bluuebunny/crossref_metadata_2025_split huggingface dataset:
Managing supply chain with green and non‐green products: Channel coordination and information asymmetry
Authors: Singh Gurmeet , Biswas Indranil , Srivastava Samir K 
Published: October 2022

AbstractWe examine a supply chain where a supplier produces partial substitutable green and non‐green products and sell them in a common market through a buyer. We analyse four scenarios: wholesale price and linear two‐part tariff contracts under full and incomplete information about the buyer's unit cost. Our result demonstrates that the value of information and trade cutoff points both increase with consumer greening sensitivity and decrease with greening investment. When green product market share exceeds a certain threshold, demand for the green product would be higher than non‐green product, even when green product is priced higher in the end market.
Evaluation of image registration algorithms for 3D phase‐resolved functional lung ventilation magnetic resonance imaging in healthy volunteers and chronic obstructive pulmonary disease patients
Authors: Klimeš Filip , Voskrebenzev Andreas , Gutberlet Marcel , Grimm Robert , Wacker Frank , Vogel‐Claussen Jens 
Published: October 2022

AbstractThe purpose of the current study was to assess the influence of the registration algorithms on the repeatability of three‐dimensional (3D) phase‐resolved functional lung (PREFUL) ventilation magnetic resonance imaging (MRI). Twenty‐three healthy volunteers and 10 patients with chronic obstructive pulmonary disease (COPD) underwent 3D PREFUL MRI during tidal breathing. The registration of dynamically acquired data to a fixed image was executed using single‐step, stepwise, and group‐oriented registration (GOREG) approaches. Advanced Normalization Tools (ANTs) and the Forsberg image‐registration package were used for the registration. Image registration algorithms were tested for differences and evaluated by the repeatability analysis of ventilation parameters using coefficient of variation (CoV), intraclass‐correlation coefficient, Bland–Altman plots, and correlation to spirometry. Also, the registration time and image quality were computed for all registration approaches. Very strong to strong correlations (r range: 0.917–0.999) were observed between ventilation parameters derived using various registration approaches. Median CoV values of the cross‐correlation (CC) parameter were significantly lower (all p ≤ 0.0054) for ANTs GOREG compared with single‐step and stepwise ANTs registration. The majority of comparisons between COPD patients and age‐matched healthy volunteers showed agreement among the registration approaches. The repeatability of regional ventilation (RVent)‐based ventilation defect percentage (VDPRVent) and VDPCC was significantly higher (both p ≤ 0.0054) for Forsberg GOREG compared with ANTs GOREG. All 3D PREFUL‐derived ventilation parameters correlated with forced expiratory volume in 1 s (FEV1) and the FEV1/ forced vital capacity (FVC) ratio (all |r| > 0.40, all p < 0.03). The image sharpness of RVent maps was statistically elevated (all p < 0.001) using GOREG compared with single‐step and stepwise registration approaches using ANTs. The best computational performance was achieved with Forsberg GOREG. The GOREG scheme improves the repeatability and image quality of dynamic 3D PREFUL ventilation parameters. Registration time can be ~10‐fold reduced to 9 min using the Forsberg method with equal or even improved repeatability and comparable PREFUL ventilation results compared with the ANTs method.
Relationship between nurses' resilience and depression, anxiety and stress during the 2021 COVID‐19 outbreak in Taiwan
Authors: Wu Chiu‐Feng , Liu Tzu‐Hung , Cheng Chu‐Hsuan , Chang Kai‐Yen 
Published: October 2022

AbstractAimThe COVID‐19 outbreak in Taiwan had a significant impact on medical services. These changes posed a threat to nurses' mental health. Resilience may protect nurses from the psychological impact of COVID‐19. This study aimed to understand nurses' resilience and its relationship with nurses' characteristics (life and work situations) and mental health (depression, anxiety and stress) during the outbreak.DesignA cross‐sectional study.MethodsThis study surveyed the nurses at a hospital from 9 August 2021, to 20 August 2021. The content of the questionnaire included nurses' characteristics, resilience and mental health.ResultsThere was an association between higher resilience and lower mental health problems. We also found that some nurses' characteristics were positively correlated with mental health problems.ConclusionSome nurses' life and work situations predicted high levels of mental health problems during the pandemic. Additionally, higher levels of resilience were associated with lower levels of mental health problems.
Self‐management experience of first‐time diagnosed gestational diabetes mellitus: A focus group interview
Authors: Su Mei‐Chen , Chang Min‐Yu , Sun Jui‐Chiung 
Published: October 2022

AbstractAimGestational diabetes mellitus (GDM) has become the most common complication in women during pregnancy in Taiwan. Since several clinical trials have demonstrated benefits of aggressive treatment, which rely heavily on self‐management. The present study was conducted to explore the self‐management experience of women with first‐time diagnosed GDM.DesignA qualitative descriptive approach was applied to conduct this study.MethodsPurposive sampling was used to recruit patients with first‐time diagnosed GDM from the maternity outpatient clinics of medical centre in Taiwan. A total of three focus groups interviews with 22 women were conducted to collect the data. Content analysis was applied to analyse the data.ResultsFour themes were identified: (1) unexpectedly having a high‐risk pregnancy, (2) different perceptions for self‐management, (3) implementation predicament of self‐management and (4) maternal duty to ensure the safety of mother and child.
Adolescent cannabis use and the later onset of bipolar disorder: protocol for a systematic review and meta‐analysis of prospective cohort studies
Authors: Yasuma Naonori , Imamura Kotaro , Watanabe Kazuhiro , Iida Mako , Takano Ayumi 
Published: October 2022

AbstractBackgroundCannabis is used by adolescents worldwide. Adolescents are more susceptible to the psychological effects of cannabis because their brains are still developing. Cannabis use in adolescents has been reportedly associated with later onset of bipolar disorder.AimsThe purpose of this study is to systematically review and analyze longitudinal prospective cohort studies of cannabis use during adolescence and evaluate the risk of developing bipolar disorder.MethodsWe defined the participants, exposures, comparisons, and outcomes (PECO) as follows: (P) adolescents in the 10–19‐year age group at the baseline survey; (E) cannabis use at least once during lifetime; (C) never‐used cannabis over lifetime; and (O) the onset of bipolar disorder. A systematic search for published prospective cohort studies will be conducted by using the following electronic databases: PubMed, EMBASE, PsycINFO, and Japan Medical Abstracts Society. The quality assessment will be performed by using Risk Of Bias In Non‐randomized Studies – of Interventions. Meta‐analysis will be done if the included studies that exist are more than three. Heterogeneity will be assessed using Cochran's Q test and I2. Funnel plots and Egger's test will be done to assess publication bias.DiscussionThis study will clarify the association between adolescent cannabis use and the subsequent development of bipolar disorder, which could be useful for future research directions and policy making.
Zooarchaeology of Ban Chiang and the rise of early farming communities in mainland Southeast Asia
Authors: Higham Charles Franklin Wandesforde , Kijngam Amphan 
Published: October 2022

AbstractBan Chiang is a prehistoric settlement located in the northeast Khorat Plateau in Thailand. Excavations in 1974–1975 identified a cultural sequence that spanned the arrival of the first rice farmers in ca. 1500 BC until the end of the Iron Age two millennia later. The large faunal sample includes the remains of mammals, fish, birds, and shellfish that illuminate aspects of the economy and environment. Domestic cattle, water buffaloes, pigs, and dogs, all domesticated in southern China, were introduced and maintained in an economy that incorporated hunting, fishing and collecting shellfish. The jungle fowl,Gallus gallus, was probably locally domesticated. When considered in its broader context, the faunal remains from Neolithic coastal Vietnamese and Thai sites present a very different picture. In the coastal sites, pigs and dogs dominate, but domestic cattle and chickens are virtually absent. The incoming farmers placed much reliance on marine hunting and fishing. Recent multidisciplinary research has identified an agricultural revolution involving animal traction and plowing in irrigated rice fields that occurred as the monsoon rains faltered from ca. AD 200. This took place in the relatively dry Mun River Valley in the southern part of the Khorat Plateau and rapidly led to the foundation of early states. Ban Chiang, however, enjoys higher natural rainfall and evidence for the agricultural revolution there appears muted or absent.
Structure and Conformation of Novel BODIPY Ugi Adducts
Authors: Arroyo‐Córdoba Ismael Javier , Gamboa‐Velázquez Gonzalo , Avila‐Ortiz Claudia Gabriela , Leyva‐Ramírez Marco A. , Cortez‐Picasso María Teresa , García‐Revilla Marco A. , Ramírez‐Ornelas Diana E. , Peña‐Cabrera Eduardo , Juaristi Eusebio 
Published: October 2022

AbstractTwo novel BODIPY‐Ugi (boron dipyrromethene) adducts exhibit peculiar room temperature (T=20 °C) H‐1 NMR spectra in that several protons located at the aromatic aniline‐type ring are lost in the baseline. This observation revealed the existence of a dynamic conformational process where rotation around the C−N bond is hindered. Variable‐temperature H‐1 and C‐13 NMR spectroscopic analysis confirmed this conclusion; that is, low‐temperature spectra show distinct signals for all four aromatic protons below coalescence, whereas average signals are recorded above coalescence (T=+120 °C). Particularly interesting was the rather large difference in chemical shifts for the ortho protons below coalescence, Δδ=1.45 ppm, which was explained based on DFT computational analysis. Indeed, the calculated lowest‐energy gas‐phase conformation of the BODIPY Ugi adducts locates one half of the aniline‐type ring in the shielding anisotropic cone of the bridge phenyl ring in the BODIPY segment. This is in contrast to the solid‐state conformation established by X‐ray diffraction analysis that shows a nearly parallel arrangement of the aromatic rings, probably induced by crystal packing forces.
Impact of the built, social, and food environment on long‐term weight loss within a behavioral weight loss intervention
Authors: Tewahade Selam , Berrigan David , Slotman Beth , Stinchcomb David G. , Sayer R. Drew , Catenacci Victoria A. , Ostendorf Danielle M. 
Published: October 2022

AbstractBackgroundBehavioral weight loss interventions can lead to an average weight loss of 5%–10% of initial body weight, however there is wide individual variability in treatment response. Although built, social, and community food environments can have potential direct and indirect influences on body weight (through their influence on physical activity and energy intake), these environmental factors are rarely considered as predictors of variation in weight loss.ObjectiveEvaluate the association between built, social, and community food environments and changes in weight, moderate‐to‐vigorous physical activity (MVPA), and dietary intake among adults who completed an 18‐month behavioral weight loss intervention.MethodsParticipants included 93 adults (mean ± SD; 41.5 ± 8.3 years, 34.4 ± 4.2 kg/m2, 82% female, 75% white). Environmental variables included urbanicity, walkability, crime, Neighborhood Deprivation Index (includes 13 social economic status factors), and density of convenience stores, grocery stores, and limited‐service restaurants at the tract level. Linear regressions examined associations between environment and changes in body weight, waist circumference (WC), MVPA (SenseWear device), and dietary intake (3‐day diet records) from baseline to 18 months.ResultsGrocery store density was inversely associated with change in weight (β = −0.95; p = 0.02; R2 = 0.062) and WC (β = −1.23; p < 0.01; R2 = 0.109). Participants living in tracts with lower walkability demonstrated lower baseline MVPA and greater increases in MVPA versus participants with higher walkability (interaction p = 0.03). Participants living in tracts with the most deprivation demonstrated greater increases in average daily steps (β = 2048.27; p = 0.02; R2 = 0.039) versus participants with the least deprivation. Limited‐service restaurant density was associated with change in % protein intake (β = 0.39; p = 0.046; R2 = 0.051).ConclusionEnvironmental factors accounted for some of the variability (<11%) in response to a behavioral weight loss intervention. Grocery store density was positively associated with weight loss at 18 months. Additional studies and/or pooled analyses, encompassing greater environmental variation, are required to further evaluate whether environment contributes to weight loss variability.
Study of three‐point bending behaviors of composite sandwich structure with re‐entrant honeycomb cores
Authors: Liu Zhikang , Liu Jingxi , Zhang Mangong , Liu Jiayi , Huang Wei 
Published: October 2022

AbstractThe composite re‐entrant honeycomb structures were fabricated by hot pressing and bonding processes in this article. The bending responses of composite re‐entrant honeycomb structure under three‐point bending load were studied experimentally. The bending deformation, failure process and failure load were analyzed and discussed. The influence of wall thickness gradient form which were less reported on the bending behaviors of composite re‐entrant honeycomb structures was investigated. The gradient distributions included positive gradient, negative gradient and homogeneous structures. The experimental results indicated that the wall thickness gradient design influenced the bending failure modes of composite re‐entrant honeycomb structures, and the negative gradient honeycomb structure mainly exhibited the whole bending deformation under three‐point bending loading. The influence of the relative densities on the bending behaviors of composite re‐entrant honeycomb structures was also studied. The results of three‐point bending experiment showed that the bending failure load increased significantly with the increase of relative density.
Design and optimization of enzymatic activity in a de novo β‐barrel scaffold
Authors: Kipnis Yakov , Chaib Anissa Ouald , Vorobieva Anastassia A. , Cai Guangyang , Reggiano Gabriella , Basanta Benjamin , Kumar Eshan , Mittl Peer R.E. , Hilvert Donald , Baker David 
Published: October 2022

AbstractWhile native scaffolds offer a large diversity of shapes and topologies for enzyme engineering, their often unpredictable behavior in response to sequence modification makes de novo generated scaffolds an exciting alternative. Here we explore the customization of the backbone and sequence of a de novo designed eight stranded β‐barrel protein to create catalysts for a retro‐aldolase model reaction. We show that active and specific catalysts can be designed in this fold and use directed evolution to further optimize activity and stereoselectivity. Our results support previous suggestions that different folds have different inherent amenability to evolution and this property could account, in part, for the distribution of natural enzymes among different folds.
Chaperoning activity of the cyclophilin family prevents tau aggregation
Authors: Hill Shannon E. , Esquivel Abigail R. , Ospina Santiago Rodriguez , Rahal Lauren M. , Dickey Chad A. , Blair Laura J. 
Published: October 2022

AbstractTauopathies, such as Alzheimer's disease, are characterized by the misfolding and progressive accumulation of the microtubule associated protein tau. Chaperones, tasked with maintaining protein homeostasis, can become imbalanced with age and contribute to the progression of neurodegenerative disease. Cyclophilins are a promising pool of underinvestigated chaperones with peptidyl‐prolyl isomerase activity that may play protective roles in regulating tau aggregation. Using a Thioflavin T fluorescence‐based assay to monitor in vitro tau aggregation, all eight cyclophilins, which include PPIA to PPIH prevent tau aggregation, with PPIB, PPIC, PPID, and PPIH showing the greatest inhibition. The low thermal stability of PPID and the strong heparin binding of PPIB undermines the simplistic interpretation of reduced tau aggregation. In a cellular model of tau accumulation, all cyclophilins, except PPID and PPIH, reduce insoluble tau. PPIB, PPIC, PPIE, and PPIF also reduce soluble tau levels with PPIC exclusively protecting cells from tau seeding. Overall, this study demonstrates cyclophilins prevent tau fibril formation and many reduce cellular insoluble tau accumulation with PPIC having the greatest potential as a molecular tool to mitigate tau seeding and accumulation.
Intrinsic protein disorder uncouples affinity from binding specificity
Authors: Lazar Tamas , Tantos Agnes , Tompa Peter , Schad Eva 
Published: October 2022

AbstractIntrinsically disordered proteins (IDPs) and intrinsically disordered regions (IDRs) of proteins often function by molecular recognition, in which they undergo induced folding. Based on prior generalizations, the idea prevails in the IDP field that due to the entropic penalty of induced folding, the major functional advantage associated with this binding mode is “uncoupling” specificity from binding strength. Nevertheless, both weaker binding and high specificity of IDPs/IDRs rest on limited experimental observations, making these assumptions more speculations than evidence‐supported facts. The issue is also complicated by the rather vague concept of specificity that lacks an exact measure, such as the Kd for binding strength. We addressed these issues by creating and analyzing a comprehensive dataset of well‐characterized ID/globular protein complexes, for which both the atomic structure of the complex and free energy (ΔG, Kd) of interaction is known. Through this analysis, we provide evidence that the affinity distributions of IDP/globular and globular/globular complexes show different trends, whereas specificity does not connote to weaker binding strength of IDPs/IDRs. Furthermore, protein disorder extends the spectrum in the direction of very weak interactions, which may have important regulatory consequences and suggest that, in a biological sense, strict correlation of specificity and binding strength are uncoupled by structural disorder.
Adaptive neural network dynamic event‐triggered control for strong interconnected stochastic nonlinear systems with output constraint
Authors: Zhu Zhechen , Zhu Quanxin 
Published: October 2022

AbstractThis paper proposes a dynamic event‐triggered mechanism based command filtered adaptive neural network (NN) tracking control scheme for strong interconnected stochastic nonlinear systems with time‐varying output constraints. By designing a state observer, the unmeasured states of the systems can be estimated. The NNs are utilized to handle the unknown intermediate functions. In the controller design process, the asymmetric time‐varying barrier Lyapunov functions are used to guarantee that the systems outputs do not violate the constraint regions. By integrating the command filter with variable separation technique, the controller design process is more simple, and the problem of algebraic‐loop can be solved which caused by interconnected functions. According to the Lyapunov stability theory, it can be ensured that all signals of the systems are bounded in probability. Finally, the availability of the developed control scheme can be showed by the simulation example.
The synergistic effect of green trade and economic complexity on sustainable environment: A new perspective on the economic and ecological components of sustainable development
Authors: Lee Chien‐Chiang , Olasehinde‐Williams Godwin , Gyamfi Bright Akwasi 
Published: October 2022

AbstractIt is commonly argued in what is termed the degrowth strategy that economic growth cannot occur side by side with environmental protection. In this study, it is instead argued that the spread of green products through economic complexity and international trade are possible means of solving this problem. To this end, the individual and interactive environmental impacts of economic complexity and international green trade are examined in a panel of 24 European Union nations between 2000 and 2018. Panel quantile regressions (QRs) and Driscoll‐Kraay fixed effect‐OLS regressions are employed in analysing the relationships. The findings reveal that both green trade and economic complexity have beneficial individual effects on the environment. Their interaction effect further confirms that they have a complementary synergistic impact on the environment of the 24 EU countries. It thus implies that both green trade and economic complexity act better together than separately. Countries interested in achieving sustainable environment can do so by raising local productive capabilities, such that they are able to quickly transition into the production of technology‐intensive, eco‐friendly items. Alternatively, they can also explore the unique benefits provided by international trade in green products in cases where they do not have the ability to locally produce certain green goods. Better still, they can pursue both objectives simultaneously.
Switchable Circularly Polarized Signals with High Asymmetric Factor Triggered by Dual Photonic Bandgap Structure
Authors: Duan Chengliang , Wang Bin , Li Jinpeng , Xu Jun , Zeng Jinsong , Li Jun , Zhao Zujin , Gao Wenhua , Ying Guangdong , Chen Kefu 
Published: October 2022

AbstractCurrently, the smart photonic materials that can switch circularly polarized signals in real‐time have attracted extensive attention due to numerous potential applications in information storage and photonics displays. However, the dynamically reversible switching of circularly polarized signals requires precise structural reconfiguration, which is rarely achieved in traditional biomaterials. Herein, a dual photonic bandgap (PBG) structure is constructed based on the optical propagation principle of cellulose‐based photonic crystals, enabling the flexible switching of the intensity, wavelength, and direction of circularly polarized luminescence (CPL). By adjusting the fluorescence intensity and the matching degree of chiral structure, the asymmetric factor value of dual PBG structure is up to −1.47, far exceeding other cellulose‐based materials. Importantly, it is demonstrated that dual CPL emission can be efficiently induced by two different PBGs, opening a new approach for on‐demand switching of single and dual CPL emission. In addition, the dual PBG structure exhibits dual circularly polarized reflected signals under the circular polarizer, which perfectly embodies the applicability of multiple encryptions in QR codes. This work provides new insights into the real‐time manipulation of circularly polarized signals by chiral photonic materials.