bluuebunny/crossref_metadata_2025_split huggingface dataset:
The environment of AGN dwarf galaxies at z ∼ 0.7 from the VIPERS survey
Authors: Siudek M , Mezcua M , Krywult J 
Published: October 2022

ABSTRACT
Dwarf galaxies are ideal laboratories to study the relationship between the environment and active galactic nucleus (AGN) activity. However, the type of environments in which dwarf galaxies hosting AGN reside is still unclear and limited to low-redshift studies (${z\lt 0.5}$). We use the VIMOS Public Extragalactic Redshift Survey (VIPERS) to investigate, for the first time, their environments at $0.5\lt {z}\lt 0.9$. We select a sample of 12 942 low-mass ($\rm {log}(\mathit{ M}_\mathrm{*}/M_{\odot })\le 10$) galaxies and use the emission-line diagnostic diagram to identify AGN. We characterize their local environments as the galaxy density contrast, δ, derived from the fifth nearest neighbour method. Our work demonstrates that AGN and non-AGN dwarf galaxies reside in similar environments at intermediate redshift suggesting that the environment is not an important factor in triggering AGN activity already since ${z=0.9}$. Dwarf galaxies show a strong preference for low-density environments, independently of whether they host an AGN or not. Their properties do not change when moving to denser environments, suggesting that dwarf galaxies are not gas-enriched due to environmental effects. Moreover, AGN presence does not alter host properties supporting the scenario that AGN feedback does not impact the star formation of the host. Lastly, AGNs are found to host overmassive black holes. This is the first study of dwarf galaxies hosting AGNs at ${z\gt 0.5}$. The next generation of deep surveys will reveal whether or not such lack of environmental trends is common also for faint higher redshift dwarf galaxy populations.
Phase II Single-Arm Study of Palbociclib and Cetuximab Rechallenge in Patients with KRAS/NRAS/BRAF Wild-Type Colorectal Cancer
Authors: Sorah Jonathan D , Moore Dominic T , Reilley Matthew J , Salem Mohamed E , Triglianos Tammy , Sanoff Hanna K , McRee Autumn J , Lee Michael S 
Published: October 2022

Abstract

Background
Cetuximab is often administered to patients with KRAS wild-type (KRAS-WT) metastatic colorectal cancer (mCRC), although resistance inevitably develops. We hypothesized that co-inhibition of the epidermal growth factor receptor (EGFR) with cetuximab and downstream cyclin-dependent kinases (CDK) 4/6 with palbociclib would be effective for anti-EGFR rechallenge in KRAS-WT mCRC.

Methods
We designed a single-arm, Simon’s 2-stage, phase II trial of cetuximab and palbociclib in KRAS-WT mCRC treated with ≥2 prior lines of therapy. We report here on cohort B rechallenging patients with anti-EGFR-based therapy who had disease control of at least 4 months on prior anti-EGFR therapy. Primary endpoint was disease control rate (DCR) at 4 months.

Results
Ten evaluable patients were enrolled in this cohort. The 4-month DCR was 20%, which did not fulfill the prespecified 4-month DCR rate to continue. Median progression-free survival was 1.8 months and median overall survival was 6.6 months. Three patients had stable disease, although overall response rate was 0%. Most common treatment-related grades 3-4 adverse events were lymphopenia and leukopenia.

Conclusion
Selection of patients for anti-EGFR rechallenge using clinical criteria alone was insufficient to identify response to palbociclib + cetuximab. Additional biomarkers are needed to select anti-EGFR rechallenge and circulating tumor DNA (ctDNA) analysis is planned for samples collected in this study. (ClinicalTrials.gov Identifier: NCT03446157)
Phosphorylation of MdCYTOKININ RESPONSE FACTOR4 suppresses ethylene biosynthesis during apple fruit ripening
Authors: Li Tong , Liu Zhi , Lv Tianxing , Xu Yaxiu , Wei Yun , Liu Weiting , Wei Yajing , Liu Li , Wang Aide 
Published: October 2022

Abstract
The plant hormone ethylene plays a central role in the ripening of climacteric fruits, such as apple (Malus domestica). Ethylene biosynthesis in apple fruit can be suppressed by calcium ions (Ca2+); however, the underlying mechanism is largely unknown. In this study, we identified an apple APETALA2/ETHYLENE-RESPONSIVE FACTOR (AP2/ERF) transcription factor, MdCYTOKININ RESPONSE FACTOR4 (MdCRF4), which functions as a transcriptional activator of ethylene biosynthesis- and signaling-related genes, including Md1-AMINOCYCLOPROPANE-1-CARBOXYLIC ACID SYNTHASE1 (MdACS1) and MdETHYLENE-RESPONSIVE FACTOR3 (MdERF3), as a partner of the calcium sensor, calmodulin. Ca2+ promoted the Ca2+/CaM2-mediated phosphorylation of MdCRF4, resulting in MdCRF4 recognition by the E3 ubiquitin ligase MdXB3 ORTHOLOG 1 IN ARABIDOPSIS THALIANA (MdXBAT31), and consequently its ubiquitination and degradation via the 26S proteasome pathway. This in turn resulted in lower expression of MdACS1 and MdERF3 and reduced ethylene biosynthesis. Transiently overexpressing various MdCRF4 proteins with specific mutated phosphorylation sites revealed that the phosphorylation state of MdCRF4 affects the ripening of apple fruit. The results reveal that a Ca2+/CaM-MdCRF4–MdXBAT31 module is involved in Ca2+-suppressed ethylene biosynthesis, which delays apple fruit ripening. This provides insights into fruit ripening that may result in strategies for extending fruit shelf life.
Optimal Feedback in Contests
Authors: Ely Jeffrey C , Georgiadis George , Khorasani Sina , Rayo Luis 
Published: October 2022

Abstract
We obtain optimal dynamic contests for environments where the designer monitors effort through coarse, binary signals—Poisson successes—and aims to elicit maximum effort, ideally in the least amount of time possible, given a fixed prize. The designer has a vast set of contests to choose from, featuring termination and prize-allocation rules together with real-time feedback for the contestants. Every effort-maximizing contest (which also maximizes total expected successes) has a history-dependent termination rule, a feedback policy that keeps agents fully apprised of their own success, and a prize-allocation rule that grants them, in expectation, a time-invariant share of the prize if they succeed. Any contest that achieves this effort in the shortest possible time must in addition be what we call second chance: once a pre-specified number of successes arrive, the contest enters a countdown phase where contestants are given one last chance to succeed.
Genetic and Geographical Associations With Six Dimensions of Psychotic Experiences in Adolesence
Authors: Maxwell Jessye , Ronald Angelica , Cardno Alastair G , Breen Gerome , Rimfeld Kaili , Vassos Evangelos 
Published: October 2022

AbstractBackground and HypothesisLarge-scale epidemiological and genetic research have shown that psychotic experiences in the community are risk factors for adverse physical and psychiatric outcomes. We investigated the associations of six types of specific psychotic experiences and negative symptoms assessed in mid-adolescence with well-established environmental and genetic risk factors for psychosis.Study DesignFourteen polygenic risk scores (PRS) and nine geographical environmental variables from 3590 participants of the Twins Early Development Study (mean age 16) were associated with paranoia, hallucinations, cognitive disorganization, grandiosity, anhedonia, and negative symptoms scales. The predictors were modeled using LASSO regularization separately (Genetic and Environmental models) and jointly (GE model).Study ResultsIn joint GE models, we found significant genetic associations of negative symptoms with educational attainment PRS (β = −.07; 95% CI = −0.12 to −0.04); cognitive disorganization with neuroticism PRS (β = .05; 95% CI = 0.03–0.08); paranoia with MDD (β = .07; 95% CI = 0.04–0.1), BMI (β = .05; 95% CI = 0.02–0.08), and neuroticism PRS (β = .05; 95% CI = 0.02–0.08). From the environmental measures only family SES (β = −.07, 95% CI = −0.10 to −0.03) and regional education levels (β = −.06; 95% CI = −0.09 to −0.02) were associated with negative symptoms.ConclusionsOur findings advance understanding of how genetic propensity for psychiatric, cognitive, and anthropometric traits, as well as environmental factors, together play a role in creating vulnerability for specific psychotic experiences and negative symptoms in mid-adolescence.
Effects of Asparagus officinalis on immune system mediated EAE model of multiple sclerosis
Authors: Aliomrani Mehdi , Rezaei Mina , Dinani Masoud Sadeghi , Mesripour Azadeh 
Published: October 2022

Abstract

Background
About 5 to 10 percent of the population in developed countries are affected by autoimmune diseases. One of the most important autoimmune disease with high prevalence rate is Multiple sclerosis in which there is currently no definitive cure for it, and most medications such as interferons are used only to limit the disease. The present study aims to investigate the effect of using Asparagus Officinalis fractions in an immune system mediated model of multiple sclerosis.

Material and Methods
Fractionation was performed by maceration using n-hexane, chloroform, chloroform-methanol (9: 1), n-Butanol and methanol solvents from aerial parts of Asparagus Officinalis. Thin layer chromatography, NMR and phenolic component measurement were done and two fractions were selected for checking in MS induced in vivo model.

Results
It was observed that chloroform-methanolic and N-Butanol fractions had higher content of saponin in comparison of other extracts. Also, it was showed that the methanolic and n-Butanol extracts contains the highestportion of glycosylic steroid saponins in comparison to other fractions. Regarding experimental autoimmune encephalomyelitis (EAE) score, Butanolic and methanolic fractions with doses higher that 100mg/kg showed a potent supportive effects as long as locomotor activity protection even in lower dose in comparison to phosphate buffered saline (PBS) group.

Conclusion
Considering the proved different effects of saponin compounds on the immune system we observed that those fractions altered the circulatory peripheral blood cells and also remit the clinical signs after EAE induction along with enhanced myelin sheath content in the median region of corpus callusom. It could be inferred that this fractions are promising candidates for further investigation as dose-dependent immune system regulating compounds in multiple sclerosis patients.
An Exploratory Analysis of Maternal Health Variables Increasing the Severity of Congenital Heart Disease in Infants
Authors: Butler Mary 
Published: October 2022

Background:
Congenital heart defects (CHD) are the most prevalent birth anomaly and leading cause of infant morbidity and mortality worldwide. Heart defects are often attributed to chromosomal abnormality or environmental factors, but most causes remain unknown. The purpose of this analysis was to explore maternal health variables and the relationships to birth outcomes in infants with CHD.

Methods:
Secondary analysis of data from the Wisconsin Pediatric Cardiac Registry.

Results:
Maternal history of CHDs (odds ratio [OR] = 2.38; 95% confidence interval [CI], 1.42-3.98) and serious health conditions (OR = 1.537; 95%: CI, 1.08-2.17) increase infant risk and CHD severity. Maternal history of hypertension, serious health conditions, CHD, obesity, and income were predictors of birth weight (R² = 0.049, P < .05). Maternal history of hypertension, influenza, serious health conditions, and housing were predictors of gestational age (R
2 = 0.045, P < .05). Birth weight (BW) and gestational age (GA) did not correlate to the severity of CHD in this study (simple vs complex, BW = −0.014, GA = 0.011, r).

Discussion:
Maternal well-being influences the health of infants born with CHD. Positive maternal health contributes to near-normal birth weight and gestational age.

Conclusion:
Nurses must discuss optimal reproductive life planning strategies for decreasing risk of CHD and other infant disorders.
Fathers' Experiences in Alberta Family Integrated Care
Authors: Shafey Amy , Benzies Karen , Amin Reshma , Stelfox Henry T. , Shah Vibhuti 
Published: October 2022

Background:
The Family Integrated Care (FICare) program adapted for Alberta (AB) level II neonatal intensive care units (NICUs) aims to increase parental involvement and support during their NICU stay. The experience of fathers of preterm infants in a FICare program is currently unknown.

Purpose:
To describe the experiences of fathers of preterm infants born at 320/7 to 346/7 weeks' gestational age with AB FICare.

Methods:
A qualitative substudy of a multicenter prospective cluster randomized controlled trial of FICare in 10 level II NICUs across Alberta. Fathers of preterm infants participated in a semistructured interview after discharge when their infants were at least 2 months' corrected gestational age. Journal entries written by fathers while in the NICU from the FICare intervention sites were also collected. Data were analyzed thematically and the interview and journal data were triangulated.

Findings:
Thirteen fathers (9 from the FICare intervention and 4 from standard care) participated in semistructured interviews and there were 24 journals collected. Seven themes emerged: fear of the unknown, mental preparation, identifying the father's role, parenting with supervision, effective communication, postneonatal intensive care transition, and family life. Fathers enrolled in AB FICare attributed their level of confidence and positive neonatal intensive care experience that continued postdischarge to the care and attention they received during hospitalization.

Conclusion:
AB FICare may improve experiences for fathers of preterm infants in the NICU with continuation postdischarge. Future research should include designing and evaluating father-specific NICU programs.
Recruitment Challenges of a Colorectal Cancer Screening Dissemination Study
Authors: Larkey Linda , Szalacha Laura A. , Bucho-Gonzalez Julie , Menon Usha 
Published: October 2022

Background
Dissemination strategies to reach underserved and minority populations to promote screening for colorectal cancer (CRC) are key to reducing disparities. We conducted a study to examine a tailored messaging approach to navigate individuals from communities (i.e., lower income, less access to care, and underscreened) to clinics to receive CRC screening. We encountered several political, demographic, and secular trend issues that required reconsideration and redesign of implementation strategies.

Objectives
Through study implementation from 2012 to 2017, changes in medical reimbursement and immigration policies—at the state level and later at the national level—affected healthcare delivery systems that had initially committed to supporting the study and our recruitment methods. Although our selected zip codes and sites had previously yielded high rates of CRC screening nonadherence, within a few years, these sites showed substantially higher screening adherence rates—yielding limited numbers of eligible participants. In addition, state immigration policy trends created mistrust and fear, leading to lower participation rates than anticipated. This report documents and provides valuable insights on how we and the community network developed creative strategies to overcome these challenges.

Methods
New relationships with community partners were extended to tap advisory board input to meet the challenges. Criteria for clinic participation widened from originally selected Federally Qualified Health Centers (FQHCs) to various nonprofit, hybrid, and privately insured reimbursement types. Recruitment site options were creatively redefined to reach community participants where they live, work, and receive services.

Results
Strategies that engage community members in identifying alternative healthcare delivery structures and that link recruitment efforts to community-based service organizations were found to be critical to recapturing community trust in the face of unfavorable political environments. Widening the type of clinic partners from FQHCs to stand-alone nonprofits and private clinics and identifying unusual types of recruitment sites provided alternative solutions for successful study implementation.

Discussion
In prevention-based studies that face unplanned system and political barriers to recruitment, embedding the study in the community may aid in reestablishing trust levels to improve engagement and recruitment of clinic partners and eligible participants.
Scoring People With Spinal Muscular Atrophy on the Motor Function Measure Using the Microsoft Kinect
Authors: Vincent-Genod Dominique , Rippert Pascal , Coton Justine , Le Goff Laure , Barriere Aurélie , Berruyer Anne , Bernard Marjorie , Garde Camille , Gutierrez-Garcia Marta , Gilabert Stéphanie , Gomes-Lisboade-Souza Adriana , Daron Aurore , Servais Laurent , Thomann Guillaume , Vuillerot Carole 
Published: October 2022

Purpose:
Assess the ability of the Kinect to capture movement and posture of people with spinal muscular atrophy (SMA) during completion of 14 items of the Motor Function Measure, a validated functional rating scale for people with neuromuscular diseases.

Methods:
Multicenter feasibility study in which Motor Function Measure items were scored as usual by the participant's therapist during the completion (Score-T) while another therapist scored items based only on the visualization of digital data collected using the Kinect (Score-D). Agreement and disagreement were investigated.

Results:
Twenty people with SMA type 2 or 3 were participants; 142 items were recorded and analyzed. There was 31.7% agreement between Score-T and Score-D for participants with SMA type 2, and 76.2% for those with SMA type 3.

Conclusions:
The results prevent us from considering the use of Kinect capture to deduce an automated scoring, but this device may be of interest to highlight potential compensations.
Distraction from pain depends on task demands and motivation
Authors: Vogel Todd A. , Falk Carl F. , Otto A. Ross , Roy Mathieu 
Published: October 2022

Abstract

Introduction:
Pain captures attention automatically, yet we can inhibit pain when we are motivated to perform other tasks. Previous studies show that engaging in a cognitively demanding task reduces pain compared with a task that is minimally demanding, yet the effects of motivation on this pain-reducing effect remain largely unexplored.

Objectives:
In this study, we hypothesized that motivating people to engage in a task with high demands would lead to more cognitive resources directed toward the task, thereby amplifying its pain-reducing effects.

Methods:
On different trials, participants performed an easy (left–right arrow discrimination) or demanding (2-back) cognitive task while receiving nonpainful or painful heat stimuli. In half of the trials, monetary rewards were offered to motivate participants to engage and perform well in the task.

Results:
Results showed an interaction between task demands and rewards, whereby offering rewards strengthened the pain-reducing effect of a distracting task when demands were high. This effect was reinforced by increased 2-back performance when rewards were offered, indicating that both task demands and motivation are necessary to inhibit pain.

Conclusions:
When task demands are low, motivation to engage in the task will have little impact on pain because performance cannot further increase. When motivation is low, participants will spend minimal effort to perform well in the task, thus hindering the pain-reducing effects of higher task demands. These findings suggest that the pain-reducing properties of distraction can be optimized by carefully calibrating the demands and motivational value of the task.
Telomere-induced senescence increases aberrant intraneuronal amyloid-β accumulation by impairing autophagy in a mouse model of Alzheimer’s disease
Authors: Suelves Nuria , Saleki Shirine , Ibrahim Tasha , Palomares Debora , Vrancx Céline , Vadukul Devkee M , Papadopoulos Nicolas , Viceconte Nikenza , Claude Eloïse , Constantinescu Stefan N. , Decottignies Anabelle , Kienlen-Campard Pascal 
Published: October 2022

AbstractAging is a well-known risk factor for Alzheimer’s disease (AD) and other neurodegenerative pathologies, but the molecular and cellular changes occurring in the aging brain are poorly understood. AD pathology seems to correlate with the appearance of cells that become senescent due to the progressive accumulation of cellular insults causing DNA damage. In this study, we investigated the role of cellular senescence on AD pathology by crossing an amyloid-β (Aβ) mouse model of AD (5xFAD) with a mouse model of senescence that is genetically deficient for the RNA component of the telomerase (Terc-/-). Our results show that accelerated senescence reduces amyloid plaque formation and Aβ levels at an age when full-blown amyloid pathology is observed in 5xFAD mice. However, early and aberrant intraneuronal Aβ accumulation is observed in the subiculum and cortical layer V of senescent mice. Selective neurodegeneration linked to telomere attrition and early intraneuronal Aβ accumulation was observed in these particular regions. Finally, our results suggest that the effect of senescence on amyloid pathology might be mediated through an alteration in autophagy function. Altogether, these findings demonstrate the instrumental role of senescence in intraneuronal Aβ accumulation associated to AD pathophysiology, and further support future approaches targeting these processes for therapeutic intervention.
Assessment of ethanol and nicotine interactions using a reinforcer demand modeling with grouped and individual levels of analyses in a long-access self-administration model using male rats
Authors: Robisona Christopher L. , Covab Nicole , Madoreb Victoria , Allenb Tyler , Barrettc Scott , Charntikov Sergios 
Published: October 2022

AbstractPrevious reports have indicated the reciprocal effects of nicotine and ethanol on their rewarding and reinforcing properties, but studies using methodological approaches resembling substance use in vulnerable populations are lacking. In our study, rats first self-administered ethanol, and their sensitivity to ethanol’s reinforcing effects was assessed using a reinforcer demand modeling approach. Subsequently, rats were equipped with intravenous catheters to self-administer nicotine, and their sensitivity to nicotine’s reinforcing effects was evaluated using the same approach. In the final phase, rats were allowed to self-administer ethanol and nicotine concurrently, investigating the influence of one substance on the rate of responding for the other substance. Group analyses revealed notable differences in demand among sucrose, sweetened ethanol, and ethanol-alone, with sucrose demonstrating the highest demand and ethanol-alone exhibiting greater sensitivity to changes in cost. At the individual level, our study finds significant correlations between rats’ demand for sucrose and sweetened ethanol, suggesting parallel efforts for both substances. Our individual data also suggest interconnections in the elasticity of demand for sweetened ethanol and ethanol-alone, as well as a potential relationship in price response patterns between ethanol and nicotine. Furthermore, concurrent self-administration of ethanol and nicotine at the group level displayed reciprocal effects, with reduced responding for nicotine in the presence of ethanol and increased responding for ethanol in the presence of nicotine. This study provides valuable insights into modeling the co-use of ethanol and nicotine and assessing their interaction effects using reinforcer demand modeling and concurrent self-administration or noncontingent administration tests. These findings contribute to our understanding of the complex interplay between ethanol and nicotine and have implications for elucidating the underlying mechanisms involved in polydrug use.