bluuebunny/crossref_metadata_2025_split huggingface dataset:
Altered EEG variability on different time scales in participants with autism spectrum disorder: an exploratory study
Authors: Hecker Lukas , Wilson Mareike , Tebartz van Elst Ludger , Kornmeier Jürgen 
Published: July 2022

AbstractOne of the great challenges in psychiatry is finding reliable biomarkers that may allow for more accurate diagnosis and treatment of patients. Neural variability received increasing attention in recent years as a potential biomarker. In the present explorative study we investigated temporal variability in visually evoked EEG activity in a cohort of 16 adult participants with Asperger Syndrome (AS) and 19 neurotypical (NT) controls. Participants performed a visual oddball task using fine and coarse checkerboard stimuli. We investigated various measures of neural variability and found effects on multiple time scales. (1) As opposed to the previous studies, we found reduced inter-trial variability in the AS group compared to NT. (2) This effect builds up over the entire course of a 5-min experiment and (3) seems to be based on smaller variability of neural background activity in AS compared to NTs. The here reported variability effects come with considerably large effect sizes, making them promising candidates for potentially reliable biomarkers in psychiatric diagnostics. The observed pattern of universality across different time scales and stimulation conditions indicates trait-like effects. Further research with a new and larger set of participants are thus needed to verify or falsify our findings.
Metformin treatment is associated with improved outcome in patients with diabetes and advanced heart failure (HFrEF)
Authors: Benes Jan , Kotrc Martin , Kroupova Katerina , Wohlfahrt Peter , Kovar Jan , Franekova Janka , Hegarova Marketa , Hoskova Lenka , Hoskova Eva , Pelikanova Terezie , Jarolim Petr , Kautzner Josef , Melenovsky Vojtech 
Published: July 2022

AbstractThe role of metformin (MET) in the treatment of patients with advanced HFrEF and type 2 diabetes mellitus (DM) is not firmly established. We studied the impact of MET on metabolic profile, quality of life (QoL) and survival in these patients. A total of 847 stable patients with advanced HFrEF (57.4 ± 11.3 years, 67.7% NYHA III/IV, LVEF 23.6 ± 5.8%) underwent clinical and laboratory evaluation and were prospectively followed for a median of 1126 (IQRs 410; 1781) days for occurrence of death, urgent heart transplantation or mechanical circulatory support implantation. A subgroup of 380 patients (44.9%) had DM, 87 of DM patients (22.9%) were treated with MET. Despite worse insulin sensitivity and more severe DM (higher BMI, HbA1c, worse insulin resistance), MET-treated patients exhibited more stable HF marked by lower BNP level (400 vs. 642 ng/l), better LV and RV function, lower mitral and tricuspid regurgitation severity, were using smaller doses of diuretics (all p < 0.05). Further, they had higher eGFR (69.23 vs. 63.34 ml/min/1.73 m2) and better QoL (MLHFQ: 36 vs. 48 points, p = 0.002). Compared to diabetics treated with other glucose-lowering agents, MET-treated patients had better event-free survival even after adjustment for BNP, BMI and eGFR (p = 0.035). Propensity score-matched analysis with 17 covariates yielded 81 pairs of patients and showed a significantly better survival for MET-treated subgroup (p = 0.01). MET treatment in patients with advanced HFrEF and DM is associated with improved outcome by mechanisms beyond the improvement of blood glucose control.
Optimal duration of cardiotocography assessment using the iPREFACE score to predict fetal acidemia
Authors: Ito Ayumu , Hayata Eijiro , Nagasaki Sumito , Kotaki Hikari , Shimabukuro Makiko , Sakuma Junya , Takano Mayumi , Oji Ayako , Maemura Toshimitsu , Nakata Masahiko 
Published: July 2022

AbstractCardiotocography (CTG) applicability to improve fetal outcomes remains controversial. This study aimed to determine the clinically optimal CTG assessment duration using the integrated score index to predict fetal acidemia by intrapartum fetal heart rate monitoring (iPREFACE score). This single-center, retrospective observational study included 325 normal full-term singleton vaginal deliveries at the Toho University Omori Medical Center, from September 2018 to March 2019. The iPREFACE(10), iPREFACE(30), and iPREFACE(60) scores were calculated at 10, 30, and 60 min immediately before delivery. The primary outcome was fetal acidemia (umbilical artery blood pH < 7.2). The secondary outcome was the correlation between all iPREFACE scores and the umbilical artery blood pH, base excess (BE), and lactate values. Patients without accurate CTG findings or with failure of umbilical artery blood sampling immediately after birth were excluded, leaving 145 patients in the final analysis. Of these, 16, three, and two had umbilical artery blood pH of < 7.2, < 7.1, and < 7.0, respectively. All iPREFACE scores significantly correlated with umbilical artery blood pH, BE, and lactate values. iPREFACE(30) had the highest predictive capacity for fetal acidemia, suggesting that 30 min immediately before delivery may be a useful scoring time in clinical practice.
Metabolic syndrome in patients with first-ever ischemic stroke: prevalence and association with coronary heart disease
Authors: Liang Yajun , Yan Zhongrui , Hao Yanlei , Wang Qiqi , Zhang Zuoji , She Rui , Wang Peng , Du Yifeng , Lau Joseph TF , Dekker Joost , Bai Bo , Qiu Chengxuan 
Published: July 2022

AbstractThe metabolic syndrome (MetS) has been well linked with coronary heart disease (CHD) in the general population, but studies have rarely explored their association among patients with stroke. We examine prevalence of MetS and its association with CHD in patients with first-ever ischemic stroke. This hospital-based study included 1851 patients with first-ever ischemic stroke (mean age 61.2 years, 36.5% women) who were hospitalized into two university hospitals in Shandong, China (January 2016–February 2017). Data were collected through interviews, physical examinations, and laboratory tests. MetS was defined following the National Cholesterol Education Program (NCEP) criteria, the International Diabetes Federation (IDF) criteria, and the Chinese Diabetes Society (CDS) criteria. CHD was defined following clinical criteria. Data were analyzed using binary logistic regression models. The overall prevalence of MetS was 33.4% by NECP criteria, 47.2% by IDF criteria, and 32.5% by CDS criteria, with the prevalence being decreased with age and higher in women than in men (p < 0.05). High blood pressure, high triglycerides, and low HDL-C were significantly associated with CHD (multi-adjusted odds ratio [OR] range 1.27–1.38, p < 0.05). The multi-adjusted OR of CHD associated with MetS defined by the NECP criteria, IDF criteria, and CDS criteria (vs. no MetS) was 1.27 (95% confidence interval 1.03–1.57), 1.44 (1.18–1.76), and 1.27 (1.03–1.57), respectively. In addition, having 1–2 abnormal components (vs. none) of MetS was associated with CHD (multi-adjusted OR range 1.66–1.72, p < 0.05). MetS affects over one-third of patients with first-ever ischemic stroke. MetS is associated with an increased likelihood of CHD in stroke patients.
Exploration and validation of metastasis-associated genes for skin cutaneous melanoma
Authors: Luan Hong , Jian Linge , He Ye , Zhang Tuo , Zhou Liping 
Published: July 2022

AbstractSkin cutaneous melanoma is a malignant and highly metastatic skin tumor, and its morbidity and mortality are still rising worldwide. However, the molecular mechanisms that promote melanoma metastasis are unclear. Two datasets (GSE15605 and GSE46517) were retrieved to identify the differentially expressed genes (DEGs), including 23 normal skin tissues (N), 77 primary melanoma tissues (T) and 85 metastatic melanoma tissues (M). Gene ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analysis were performed to explore the functions of the DEGs. We constructed protein–protein interaction network using the STRING database and Cytoscape software. Using the cytoHubba plugin of Cytoscape, we identified the most significant hub genes by five analytical methods (Degree, Bottleneck, MCC, MNC, and EPC). Hub gene expression was validated using the UALCAN website. Clinical relevance was investigated using The Cancer Genome Atlas resources. Finally, we explored the association between metastasis-associated genes and immune infiltrates through the Tumor Immune Estimation Resource (TIMER) database and performed drug–gene interaction analysis using the Drug-Gene Interaction database. A total of 294 specific genes were related to melanoma metastasis and were mainly involved in the positive regulation of locomotion, mitotic cell cycle process, and epithelial cell differentiation. Four hub genes (CDK1, FOXM1, KIF11, and RFC4) were identified from the cytoHubba plugin of Cytoscape. CDK1 was significantly upregulated in metastatic melanoma compared with primary melanoma, and high CDK1 expression was positively correlated with worse overall survival. Immune infiltration analysis revealed that CDK1 expression negatively correlated with macrophage infiltration (Rho = − 0.164, P = 2.02e−03) and positively correlated with neutrophil cells (Rho = 0.269, P = 2.72e−07) in SKCM metastasis. In addition, we identified that CDK1 had a close interaction with 10 antitumor drugs. CDK1 was identified as a hub gene involved in the progression of melanoma metastasis and may be regarded as a therapeutic target for melanoma patients to improve prognosis and prevent metastasis in the future.
Upregulation of the hypothalamo-neurohypophysial system and activation of vasopressin neurones attenuates hyperalgesia in a neuropathic pain model rat
Authors: Baba Kazuhiko , Kawasaki Makoto , Nishimura Haruki , Suzuki Hitoshi , Matsuura Takanori , Ikeda Naofumi , Fujitani Teruaki , Yamanaka Yoshiaki , Tsukamoto Manabu , Ohnishi Hideo , Yoshimura Mitsuhiro , Maruyama Takashi , Sanada Kenya , Sonoda Satomi , Nishimura Kazuaki , Tanaka Kentaro , Onaka Tatsushi , Ueta Yoichi , Sakai Akinori 
Published: July 2022

AbstractArginine vasopressin (AVP) is a hypothalamic neurosecretory hormone well known as an antidiuretic, and recently reported to be involved in pain modulation. The expression kinetics of AVP and its potential involvement in the descending pain modulation system (DPMS) in neuropathic pain (NP) remains unclear. We investigated AVP expression and its effects on mechanical and thermal nociceptive thresholds using a unilateral spinal nerve ligation (SNL) model. All rats with SNL developed NP. Intensities of enhanced green fluorescent protein (eGFP) in the supraoptic and paraventricular nuclei, median eminence, and posterior pituitary were significantly increased at 7 and 14 days post-SNL in AVP-eGFP rats. In situ hybridisation histochemistry revealed significantly increased AVP mRNA expression at 14 days post-SNL compared with the sham control group. The chemogenetic activation of AVP neurones significantly attenuated mechanical and thermal hyperalgesia with elevated plasma AVP concentration. These analgesic effects were suppressed by pre-administration with V1a receptor antagonist. AVP neurones increased the neuronal activity of serotonergic dorsal raphe, noradrenergic locus coeruleus, and inhibitory interneurones in the spinal dorsal horn. These results suggest that the hypothalamo-neurohypophysial system of AVP is upregulated in NP and activated endogenous AVP exerts analgesic effects via the V1a receptors. AVP neurones may activate the DPMS.
Robust transmit beamforming design for multi‐cell multiuser MIMO NOMA
Authors: Mohammadkhani Saeideh 
Published: July 2022

AbstractThis paper focuses on the robust beamforming design for downlink multi‐cell multiple‐input multiple‐output (MIMO) nonorthogonal multiple access (NOMA) systems without having any restrictions on the number of users and cells. The beamforming matrices are designed by solving a sum rate maximization problem under imperfect channel state information (CSI) while satisfying transmission power constraints. In order to solve the proposed non‐convex optimization problem with infinite‐dimensional robust constraints, an iterative algorithm is provided to transform this problem into a convex form by utilizing diagonalization theory and introducing some auxiliary variables. Numerical results demonstrate that the proposed algorithm converges quickly, and the proposed robust NOMA design achieves strong robustness and acceptable performance.
Achieving an optimal group structure in a neural architecture search
Authors: Seo W. , Park J. , Lim W. , Kim D. , Lee J. 
Published: July 2022

AbstractThe method proposed in this letter searches for an effective group structure of group convolutions in a convolutional neural network that can improve the classification accuracy. The model's group structure is obtained using an effective differential neural architecture search. Our code can be accessed at https://github.com/minercode625/grunas.git.
Flying‐inductor‐cell based inverters for single‐phase transformerless PV applications
Authors: Aalami Mohammad Reza , Zarif Mahdi , Alishahi Mohammad , Shojaei Ali Asghar , Doostabad Hamed Heydari 
Published: July 2022

AbstractThe application of the general flying‐inductor (FI) cell in two novel transformerless photo‐voltaic (PV) inverters are proposed and investigated. The simultaneous step up and down ability is possible with both topologies, while a high conversion efficiency and a high‐quality AC current are achieved. The leakage current problem, which is a main concern with the transformerless PV inverters, is also considered. One of the proposed topologies presents a higher efficiency, while the other one provides the high quality of injected current with the lowest number active switches. The current control, especially at transition modes of operation is highly improved by utilizing a fast response dead‐beat control scheme. The working principles of the proposed converters are explained in details and 0.88‐kW experimental prototypes are implemented to confirm the theoretical achievements. Finally, a comparison with other existing topologies has been investigated for better clarification of the advantages and disadvantages of the proposed inverters.
Spatial disconnection between stellar and dust emissions: The test of the Antennae Galaxies (Arp 244)
Authors: Seillé L.-M. , Buat V. , Haddad W. , Boselli A. , Boquien M. , Ciesla L. , Roehlly Y. , Burgarella D. 
Published: July 2022

Context. The detection of dust-rich high-redshift galaxies with the Atacama Large Millimeter Array (ALMA), the cold dust emission of which is spatially disconnected from the ultraviolet emission, bears a challenge for modelling their spectral energy distributions (SEDs) with codes based on an energy budget between the stellar and dust components.
Aims. We want to test the validity of energy balance modelling on a nearby resolved galaxy with vastly different ultraviolet and infrared spatial distributions and to decipher the kinds of information that can be reliably retrieved from the analysis of the full SED.
Methods. We used 15 broadband images of the Antennae Galaxies ranging from far-ultraviolet to far-infrared and divided Arp 244 into 58 square ∼1 kpc2 regions. We fit the data with CIGALE to determine the star formation rate, stellar mass, and dust attenuation of each region. We compared these quantities to those obtained for Arp 244 as a whole.
Results. The SEDs of the 58 regions and Arp 244 are well fitted. The estimates of the star formation rate and stellar mass for the whole galaxy are found to be consistent – within one sigma – with the same parameters summed over the 58 regions. We present the spatial distribution of these physical parameters as well as the shape of the attenuation curve across the Antennae Galaxies. We find that the Overlap Region exhibits a high star formation rate, attenuation, and a shallow attenuation curve. We observe a flattening of the attenuation curves with increasing attenuation and dust surface density in agreement with the predictions of hydrodynamical simulations coupled with radiative transfer modelling.
And the subsidiary lives on: Harnessing complex realities in the contemporary MNE
Authors: Andrews Daniel S. , Nell Phillip C. , Schotter Andreas P. J. , Laamanen Tomi 
Published: July 2022

AbstractManaging multinational enterprise subsidiaries is a core facet of international business research. A shifting reality on the ground has triggered concerns around the waning relevance of the subsidiary because the MNE and its structure and processes have become increasingly complex. Consequently, more decentralized, responsive, and fluid organizational designs are now at the core of IB research. Juxtaposing recent arguments questioning subsidiary research altogether, we argue that IB scholars can explore and explain complex realities in the contemporary MNE without unnecessarily restricting the breadth of the field and giving up links to established research and theory. We reframe conversations around inward- and outward-looking perspectives, providing a path forward that emphasizes the importance of embracing the subsidiary concept in research reflecting today’s complex business environment.
Effect of social media usage on the cultural identity of rural people: a case study of Bamha village, Egypt
Authors: Radwan Mostafa 
Published: July 2022

AbstractCultural identity refers to the identical compound of reminiscences, impressions, ideologies, images, idioms, inventions, and ambitions that maintains a human set’s civilizational identity within the framework of what it knows of developments due to its internal dynamism and its ability to communicate or give and take. Social Media’s deep effect on cultural identity is a matter of constant concern. Therefore, the main aim of this research was to recognize the effect of social media on some components of rural people’s cultural identity. This study was conducted on 360 respondents from rural people in Bamha village, Egypt. Our data were collected using a questionnaire in December 2021 and then analyzed using descriptive statistics, Pearson’s simple correlation coefficient, chi-square, and the ascending multiple regression correlation analysis model (Stepwise). The results showed that for two-fifths of the respondents (40%) the level of change in cultural identity was high in relation to their use of social media; there is a significant relationship between some independent variables of respondents and the degree of change in their cultural identity. These results have important implications for policy, practice, and subsequent research, the most important of which are: working on developing thinking skills and self-learning among students in schools and universities, as well as the need to activate the role of the media in providing meaningful content that preserves societal values, in addition to employing social media to support community participation of young people on the ground by organizing awareness, volunteer and charitable activities, and finally the need to increase cooperation and coordination between all parties, whether they are media, schools, religious or civil institutions, youth centers, or other institutions to maximize the positive use of social media and to reduce its negative effects.
Gurney model for non-standard cylinder with increased wall thickness and its application in aluminized explosives
Authors: Shen Fei , Wang Jintao , Li Chao , Yu Wenli , Wang Xuanjun 
Published: July 2022

To meet the requirements of an aluminized explosive cylinder test with a longer energy release time, a non-standard cylinder structure with a larger wall thickness was designed, which can not only extend the effective expansion time of detonation products but also avoid a great increase in the test charge mass. The non-standard cylinder was filled with TNT explosives for its relatively stable Gurney energy, and the experimentally generated parameters were compared with those of Φ50 and Φ100 mm standard cylinders. Based on this, a more accurate Gurney Model for Non-Standard Cylinder (GM-NSC) was proposed taking into account the influence of shell deformation and axial movement of detonation products compared with the traditional Gurney model. The analysis results show that the proposed GM-NSC model curve is suitable for both non-standard and standard cylinders. Finally, the method was applied to DNAN-based aluminized explosives, and the experimental results show that the method can characterize more thoroughly the effect of the detonation product expansion enhanced by the rapid reaction of aluminum powders.
The evolution of the geothermal potential of a subsurface urban heat island
Authors: Hemmerle Hannes , Ferguson Grant , Blum Philipp , Bayer Peter 
Published: July 2022

Abstract
Meeting the rising energy demands of cities is a global challenge. Exploitation of the additional heat in the subsurface associated with the subsurface urban heat island (SUHI) has been proposed to address the heating demands. For the sustainable use of this heat it is crucial to understand how SUHIs evolve. To date, there have been no comprehensive studies showing how temperature anomalies beneath cities change over time scales of decades. Here, we reveal the long-term increase of temperatures in the groundwater beneath Cologne, Germany from 1973 to 2020. The rise in groundwater temperature trails atmospheric temperature rise in the rural areas and exceeds the rise in atmospheric temperature in the urban center. However, the amount of heat that is currently stored each year in the thin shallow aquifer reaches only 1% of the annual heating demand. The majority of the anthropogenic heat passes by the vertical extent of the aquifer or is discharged by the adjacent river. Overall the geothermal resource of the urban ground remains largely underused and heat extraction as well as combined heating and cooling could substantially raise the geothermal potential to supply the city’s demand.
Efficacy of Doxycycline for Mild-to-Moderate Community-Acquired Pneumonia in Adults: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Authors: Choi Sang-Ho , Cesar Antoni , Snow Timothy Arthur Chandos , Saleem Naveed , Arulkumaran Nishkantha , Singer Mervyn 
Published: July 2022

AbstractBackgroundDoxycycline has been recommended as a treatment option for non-severe community-acquired pneumonia (CAP) in adults. We sought to review the evidence for the efficacy of doxycycline in adult patients with mild-to-moderate CAP.MethodsWe performed a systematic review and meta-analysis of randomized controlled trials (RCTs) of doxycycline versus comparator to assess the clinical efficacy. The primary outcome was the clinical cure rate. Random effects model meta-analyses were used to generate pooled odds ratio (OR) and evaluate heterogeneity (I2). Risk of bias (RoB) and quality of evidence (QoE) were evaluated using the Cochrane Risk of Bias 2.0 tool and GRADE methods, respectively.ResultsWe included 6 RCTs with 834 clinically evaluable patients. The trials were performed between 1984 and 2004. Comparators were 3 macrolides (roxithromycin, spiramycin, and erythromycin) and 3 fluoroquinolones (ofloxacin, fleroxacin, and levofloxacin). Four trials had an overall high RoB. The clinical cure rate was similar between the doxycycline and comparator groups (87.2% [381/437] vs 82.6% [328/397]; OR 1.29 [95% confidence interval {CI}: .73–2.28]; I2 = 30%; low QoE). Subgroup analysis of two studies with a low RoB showed significantly higher clinical cure rates in the doxycyline group (87.1% [196/225] vs 77.8% [165/212]; OR 1.92 [95% CI: 1.15–3.21]; P = .01; I2 = 0%). Adverse event rates were comparable between the doxycycline and comparator groups.ConclusionsThe efficacy of doxycycline was comparable to macrolides or fluoroquinolones in mild-to-moderate CAP and thus represents a viable treatment option. Considering the lack of recent trials, it warrants large-scale clinical trials.