bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Novel Extracorporeal Cardiopulmonary Resuscitation Strategy Using a Hybrid Emergency Room for Patients With PEA
Authors: Ijuin Shinichi , Inoue Akihiko , Ishihara Satoshi , Suga Masafumi , Nishimura Takeshi , Kikuta Shota , Nakayama Haruki , Igarashi Nobuaki , Matsuyama Shigenari , Doi Tomofumi , Nakayama Shinichi 
Published: March 2022

Abstract
Background: Whether extracorporeal cardiopulmonary resuscitation (ECPR) is indicated for pulseless electrical activity (PEA) remains unclear. Pulmonary embolism with PEA was a good candidate for ECPR; however, PEA sometimes include an aortic disease and intracranial haemorrhage, with extremely poor neurological outcomes, and could not be a candidate. We have induced an ECPR strategy using the hybrid emergency room (ER) to perform computed tomography (CT) before extracorporeal membrane oxygenation (ECMO) induction from January 2020. Therefore, this study aimed to evaluate the effectiveness of our ECPR strategy.Methods: Medical records of patients who transferred to our hybrid emergency room (ER) and required ECPR for PEA between January 2020 and November 2021 were reviewed.Results: Twelve consecutive patients (median age, 67 [range, 57-73] years) with PEA requiring ECPR were identified in our hybrid ER. Among them, nine were diagnosed through initial CT scan (intracranial haemorrhage, 3; cardiac tamponade due to aortic dissection, 3; aortic rupture, 2; and cardiac rupture, 1), and unnecessary ECMO was avoided. The remaining three patients underwent ECPR, and two of them survived with favourable neurological outcomes. All patients not indicated for ECPR were excluded before ECMO induction.Conclusion: Our ECPR strategy using the hybrid ER may be useful for the exclusion of patients with PEA non-indication for ECPR and decision making.
The influence of cognitive training on brain dynamics
Authors: Lv Guiyang , Xu Tianyong , Zhu Ping , Wang Miao , Chen Feiyan , He Guoguang 
Published: March 2022

Abstract
The human brain is highly plastic. Cognitive training can make a change in functional connections between brain regions. The structures of brain networks may determine its dynamic behavior which is related to human cognitive abilities. To study the effect of functional connectivity on the brain dynamics, a dynamic model is established based on functional connectivity of the brain and the Hindmarsh-Rose model in this work. The resting-state fMRI data from the experimental group undergoing abacus-based mental calculation (AMC) training and from the control group are used to construct the functional brain networks. The local efficiency and global efficiency of the functional brain networks of the experimental group are higher than those of the control group. The dynamic behavior of brain at the resting and task states for the AMC group and the control group are simulated based on above dynamic model. In the resting state, some different activated brain regions exist between the AMC group and the control group. A stimulus with sinusoidal signals to brain networks is introduced to simulate the brain dynamics in the task states. The dynamic characteristics are extracted by the excitation rates, the response intensities and the state distributions. The change in the functional connections of brain regions with the AMC training would in turn improve the brain response to external stimulus, and make the brain more efficient in processing related tasks.
The Temporal Clustering of Storm Surge, Wave Height, and High Sea Level Exceedances Around the UK Coastline
Authors: Jenkins Luke Joe , Haigh Ivan , Camus Paula , Pender Douglas , Sansom Jenny , Lamb Rob , Kassem Hachem 
Published: March 2022

Abstract
The temporal clustering of storms presents consecutive storm surge and wave hazards that can lead to amplified flood and erosional damages; thus, clustering is important for coastal stakeholders to consider. We analyse the prevalence of storm clustering around the UK coastline by examining the temporal and spatial characteristics of storm surge, wave height, and high still sea level exceedances at the 1 in 1- and 5-year return levels. First, at the interseasonal timescale, we show that there are periods of high/low exceedance counts on national and regional scales. Elevated seasonal counts of lower-magnitude exceedances can occur without a respective signal of higher-magnitude exceedances. Secondly, at the intraseasonal timescale, we show that high proportions of exceedances are clustering within seasons. Storm surge, wave height and still sea level exceedances occurring <50 days after the prior account for ~35-44% (~15-22%) of those at the 1 in 1- (5-) year return level. Still sea levels have the highest degree of clustering, with ~25% of 1 in 1-year exceedances occurring <2 days after the previous. Spatially, for UK storm surges and still sea levels, the North Sea has the lowest proportion of clustering, whereas the North Atlantic and Bristol Channel have the highest. For English wave records, the North Sea and English Channel have the highest proportion of clustered lower- and higher-magnitude exceedances, respectively. These findings illuminate the prevalence of the clustering of coastal hazards around the UK – helping coastal stakeholders evaluate the threat of surges, waves, and sea levels clustering over short periods.
Impact of Daratumumab on Anti-HLA Antibodies Level in Patients with Multiple Myeloma
Authors: Theves Floriane , Kheav David , Talbot Alexis , Peraldi Marie-Noelle , Villesuzanne Camille , Harel Stephanie , Royer Bruno , Lepretre Anne-Claire , Carmagnat Maryvonnick , Taupin Jean-Luc , Arnulf Bertrand 
Published: March 2022

Abstract
Daratumumab, a humanized anti-CD38 monoclonal antibody, has demonstrated anti-plasma cell activity alone and in combination with other drugs in multiple myeloma (MM) and in light chain amyloidosis (AL). Allogenic anti-Human leukocyte antigen (HLA) antibodies are frequently encountered in patients awaiting kidney transplantation, complicating the access to a compatible transplant and represent a major risk factor of humoral rejection. Durably removing the antibodies or eliminating the producing cells is an objective that is currently out of reach. The objectives of our study were to evaluate the frequency of anti-HLA antibodies in MM and AL patients, and to determine the effect of daratumumab on them. Eligible patients with diagnosed MM or AL were selected (n = 182), among whom 84 had anti HLA antibodies (46%). Forty-nine patients (45 MM and 4 AL) were retrospectively included. Patients were treated with a combination of an alkylating agent, an immunomodulatory imide drug (IMiD), a Proteasome inhibitor, with (n = 22) or without (n = 22) daratumumab. Five patients received daratumumab alone. Treatment with daratumumab lowered anti-HLA antibodies in 85% (23/27) of cases including complete loss in 56% of cases (15/27) compared to 77% (17/22) and 45% (10/22) respectively, p = 0.8. This study couldn’t find a statistic impact of daratumumab to lower HLA antibody in this cohort. The association with chemotherapy could be an important bias and this hypothesis will be evaluated in ongoing studies enrolling patients undergoing kidney transplantation.
Latent Classes of Early Response Trajectories to Biologics Initiation in Juvenile Idiopathic Arthritis: An Analysis of Four Trials
Authors: Lim Lily Siok Hoon , Shobhan Shamsia , Lokku Armend , Ringold Sarah , Pullenayegum Eleanor 
Published: March 2022

Abstract
Aims: 1) To delineate latent classes of treatment response to biologics in juvenile idiopathic arthritis (JIA) patients in the first 16 weeks after initiation. 2) To identify predictors of early disease response. Methods: The study population was drawn from four biologics trials in polyarticular course JIA: Etanercept 2000, Abatacept 2008, TRial of Early Aggressive Therapy (TREAT) 2012 and Tocilizumab 2014. The outcome was active joint counts (AJC). Semiparametric latent class trajectory analysis was applied to identify latent classes of response to treatment; AJC was transformed for this modelling. We tested baseline disease and treatment characteristics for their abilities to predict class membership of response. Results: There were 480 participants, 74% females. At baseline, 26% were rheumatoid factor positive. 67% were on methotrexate at enrollment. Three latent class solution provided the best fit. Baseline AJC was the sole best predictor of class membership. Participants classified by their highest membership probabilities into high baseline AJC (>30) and slow response (26.5%), low baseline AJC (<10), early and sustained response (29.7%), and moderate baseline AJC progressive response (43.8%). Participants were classified into the latent classes with a mean class membership posterior probability 0f 0.97. Those on methotrexate at baseline were less likely to belong to high baseline AJC class. Conclusions: Three latent classes of responses were detectable in the first 16 weeks of biologics therapy. Those with the highest baseline AJC demonstrated very slow response in this window and were less likely to be on concomitant methotrexate. Trials Registration: TREAT 2012 (NCT NCT00443430)(1), tocilizumab trial 2014 (NCT00988221), abatacept trial 2008 (NCT00095173). Etanercept 2000 from Amgen does not have a trial registration number.
IBD Patients Show a Unique Skin Microbiota Composition and a Correlation Pattern Between Serological Biomarkers and Clinical Aspects During Skin Adverse Events in the Setting of Anti-TNFα Therapy
Authors: Stehlikova Zuzana , Rob Filip , Kolar Martin , Schierova Dagmar , Kreisinger Jakub , Jackova Zuzana , Roubalova Radka , Coufal Stepan , Mihula Martin , Thon Tomas , Bajer Lukas , Novakova Michaela , Vasatko Martin , Kostovcikova Klara , Galanova Natalie , Lukas Milan , Kverka Miloslav , Hercogova Jana , Tlaskalova-Hogenova Helena , Zakostelska Zuzana Jiraskova 
Published: March 2022

Abstract
Background
Crohn’s disease (CD) and ulcerative colitis (UC) are two forms of inflammatory bowel disease (IBD), where gut but not skin dysbiosis is well recognized. Tumor-necrosis factor alpha (TNFα) blockers have been successful in IBD treatment, but up to a quarter of patients suffer from skin adverse events (SkAE), for which we do not have a tool to predict them. Therefore, we examined the skin microbiota composition of IBD patients at several body sites by 16S bacterial profiling. Moreover, we quantified 22 serum markers of inflammation and epithelial barrier disruption in the setting of anti-TNFα therapy and SkAE manifestation by ELISA.
Results
The skin microbiota signature of IBD patients differed markedly from healthy subjects. In particular, skin microbiota of CD patients differed significantly from that of UC and HC at the retroauricular crease. CD patients showed high abundance of Corynebacterium (ASV86) and lower abundance of Actinomyces (ASV28), Cutibacterium (ASV212), Lawsonella (ASV87), and other taxa compared to HC. UC patients showed higher abundance of Delftia (ASV1039) and Pseudomonas (ASV1183), and lower abundance of Actinomyces (ASV28), Streptococcus (ASV607), or Haemophilus (ASV1150) than HC. Although microbiome changes were correlated at the ASV level in CD and UC patients compared to HC, we identified some bacterial ASV’s that exhibited changes typical of individual IBD forms. Manifestation of SkAE during anti-TNFα therapy was associated with a specific microbiota profile on the skin, and with a decrease in serum levels of L-FABP and I-FABP.
Conclusions
The overall proinflammatory effect of IBD might predispose for altered skin microbiota composition, hence promoting SkAE manifestation during anti-TNFα therapy. We identified specific serum markers associated with the incidence of SkAE during anti-TNFα therapy, however, further studies are needed to shed light on the impact of microbiota in this matter. Combining sequencing technology with search for serum biomarkers has opened up new opportunities in studying SkAE related to anti-TNFα therapy. Early detection of changes in microbiota-host equilibrium may have beneficial consequences in revealing the pathogenesis of SkAE in IBD.
Clinical Significance and Bioinformatics Analysis of SMC Family in Pancreatic Adenocarcinoma
Authors: Li Mingxu , Zhong Chengcheng , Sun Dan , Fei Haoran , Hu Wei , Wang Yan , Wang Zhong 
Published: March 2022

Abstract
Objective: Pancreatic adenocarcinoma (PAAD) is a malignant digestive tract tumor with a dismal prognosis. The structural maintenance of chromosomes (SMC) gene family plays a role in various of human cancers. However, the function of SMC family members in PAAD remains unclear. This study explores the potential clinical significance of SMC family members in PAAD.Methods: We analyzed the differential expression, prognostic value and methylation levels of SMCs in PAAD patients using R language, Gene Expression Profile Interactive Analysis (GEPIA), University of Alabama Cancer Database (UALCAN). We used Tumor Immune Estimation Resource (TIMER) to assess the correlation between SMC2 and six major tumor-infiltrating immune cells. Immunohistochemistry (IHC) was used to detect the expression of SMC2 in 72 PAAD tissues and 65 adjacent tissues. The relationship between SMC2 and the clinicopathological characteristics and prognosis of PAAD was further analyzed according to the clinical data of the patients.Result: In TCGA (The Cancer Genome Atlas) and GSE16515, GSE15471 datasets, compared to normal tissue, the mRNA and protein expression levels of SMC1A, SMC2, SMC3, SMC4, and SMC6 were higher in PAAD. In addition, increased expression of SMC2 led to a poor prognosis, which could be a potential prognostic biomarker for PAAD patients in TCGA, GSE28735 and GSE21501. Cox univariate and multivariate analysis showed that SMC2 was a prognostic risk factor for PAAD patients in TCGA and GSE21501 dataset. In the 72 PAAD patients of our hospital, the expression level of SMC2 in PAAD tissues was significantly higher than in adjacent tissue, and patients with high expression had a shorter Overall Survival (OS); the expression of SMC2 was related to N stage (P=0.028) and Pathologic stage (P=0.048) of PAAD. Cox univariate and multivariate analysis suggested that SMC2 and N stage were closely related to the prognosis of PAAD patients. Using KEGG (Kyoto Encyclopedia of Genes and Genomes) and GO (Gene Ontology) analysis, we analyzed the gene expression enrichment of SMC2 in biological functions and pathways. Immune infiltration analysis showed that SMC2 was closely associated with B cells, CD8+ T cells, macrophages, neutrophils and dendritic cells. Conclusions: Our study provides a new approach for selecting SMC family prognostic biomarkers in pancreatic cancer. These findings may provide a new direction for diagnosing and treating PAAD in the future.
A Qualitative Study into Perception, Experience, and Response of Intimate Partner Violence among Syrian Refugee Women in Heidelberg, Germany
Authors: Ahmad Arwa , Benson-Martin Janine , Jahn Albrecht , Beiersmann Claudia 
Published: March 2022

Abstract
Background
Intimate partner violence and domestic violence are the most prevalent forms of gender-based violence against women. They pose a significant public health concern with physiological and psychological impacts on women and the society as a whole. Asylum seekers, refugees and undocumented migrants tend to be more prone to psychological and mental distress and refugee women are an especially vulnerable group with regards to intimate partner violence.
Methods
We investigated the experiences, perceptions and attitudes towards IPV through interviews with Syrian refugee women, migrated to Germany. The qualitative study consisted of ten purposefully sampled Syrian women granted refuge within the city of Heidelberg.
Results
An ideological patriarchal and religious belief system condoned the use of violence towards women as punishment. Women highlighted challenges as well as advantages of living in a foreign culture in their post-settlement country. Men may become more violent as they lose their role as breadwinner and provider. The new social environment is perceived to provide more personal freedom and opportunities, but also to be rather destabilizing for matrimonial relationships.
Conclusions
We stress the importance of culturally sensitive approaches in resolving family conflict; the need to explore IPV amongst male refugees, and to further explore the fear behind the concept of “women empowerment” among the refugee community.
MedionRep: Medical Ontology Representation using Graph Embedding with Medical Text
Authors: Kim Young Hak , Song Jee Eun , Jun Tae Joon 
Published: March 2022

Abstract
Background: Electronic Medical Record (EMR) is an electronic record of a patient’s health information. Nowadays, the importance of EMR analysis is increasing in medical informatics. An EMR is multi-modal data containing medical text and medical concepts. Recent studies attempt to embed either medical text or medical concepts to analyze an EMR partially. However, no type of embedding understands an entire EMR, including both the medical text and the medical concepts. Moreover, most medical concept embeddings train concept sequences from the EMR. These embeddings do not reflect the ontology of the medical concepts, which contain medical semantics. Thus, this study proposes a novel medical ontology representation with medical text for understanding an entire EMR. Methods: First, we generated the International Classification of Disease (ICD)-10 graph using the ICD-10 graph dataset we created and initialized each node based on the pre-trained medical text embedding. Next, the ICD-10 nodes were trained by the code sequences sampled from the ontology using the encoder-decoder-based graph embedding. Lastly, we trained the ICD-10 nodes by the relation between the ICD code and the text.Results: For quantitative evaluation, we created similarity pairs of the ICD-10 codes dataset and compared the similarities of the ICD-10 code pairs. The average cosine similarity of ours is 0.87, which is the highest average among the comparison models. We also conducted a comparison of the similarity pairs using open datasets. The pearson correlation coefficients of ours are about 0.461 to 0.463, which is similar to the best model, 0.464. Both comparisons demonstrated that our medical ontology embedding performed well while maintaining the medical text embedding characteristics. Conclusions: In this study, we proposed a MedionRep which is a medical ontology representation method using graph embedding with medical text. MedionRep is a new medical concept embedding method with medical text and reflect the ontology of the medical concept including medical semantics. Our method could broaden the analysis of the EMR data, which includes several types of medical data.
Serum proteomics analysis from rheumatoid arthritis patients receiving combination therapy of imrecoxib, total glucosides of paeony and two DMARDs
Authors: Yu Haixia , Ma Xuejing , Fang Xing , Yang Chunlan , Fang Xianjun , Wang Tingting , Qin Lanxin , Xia Quan 
Published: March 2022

Abstract
Background：Rheumatoid arthritis (RA) is a chronic autoimmune disease. Imrecoxib, disease-modifying anti-rheumatic drugs (DMARDs) and total glucosides of paeony (TGPs) are common clinical therapies for RA. However, the exact mechanism of combination therapy for rheumatoid arthritis is still unclear. This study aims to explore the potential mechanism of this combination therapy for RA.Methods：Five RA patients who used this combination drug therapy were enrolled. Serum was collected at the first visit and the second visit after 3 months of continuous use of the combination treatment. Label-free quantitative proteomics was used to perform a comparative analysis of protein expression in serum after depletion of high-abundance proteins. The GO database was used to annotate the functions of differentially expressed proteins (DEPs).Results： A total of 257 reliable proteins were identified. Six proteins (IGKV3-20, TTR, LRG1, SERPINA3, F10 and NMNAT3) were downregulated, and one protein (HBD) was upregulated after three months of continuous combination drug treatment. Bioinformatics analysis showed that DEPs were primarily involved in various biological processes, such as metabolic processes, cellular processes and biological regulation. The identified DEPs have been reported to be involved in inflammation, cell proliferation, angiogenesis and oxidative stress. Therefore, these proteins have played important roles in RA progression.Conclusion： This combination drug therapy could alleviate the symptoms of RA by regulating these DEPs associated with RA in different ways. The DEPs identified may help to predict the treatment outcome of therapy for RA in the future.
Transversus Abdominis Release (TAR) Procedure a retrospective analysis of an abdominal wall reconstruction group
Authors: Chaves Carlos Eduardo Rey , Girón Felipe , Conde Danny , Rodriguez Lina , Venegas David , Vanegas Marco , Pardo Manuel , Barato Felipe Vargas - , Navarro Jorge , Ricaurte Alberto 
Published: March 2022

Abstract
Background
Complex abdominal wall defects are important conditions with a high morbidity, leading to impairment of patients physical condition and quality of life. In the last decade, the abdominal wall reconstruction paradigm has changed due to formation of experienced and excellence groups, improving clinical outcomes after surgery. Therefore, our study shows the perspective and outcomes of an abdominal wall reconstruction group (AWRG) in Colombia, focused on transverse abdominis release (TAR) procedure.
Methods
A retrospective review of a prospectively collected database was conducted. All the patients older than 18 years old that underwent TAR procedure between January 2014 – December 2020 were included. Analysis and description of postoperative outcomes (recurrence, surgical site infection (SSI), seroma, hematoma, and re-intervention) was performed.
Results
50 patients underwent TAR procedure. 62% of patients were male. Mean age was 55 ± 13.4 years. Mean BMI was 27.8 ± 4.5 Kg/m2. Abdominal wall defects were classified with EHS ventral Hernia classification having a W3 hernia in 72% of all defects (Mean gap size of 11.49 cm ± 4.03 cm). Mean CeDAR preoperative risk score was 20.5% ± 14.5%. Protective association was established for SSI if the procedure was performed by the AWRG OR 0.7 (IC 95% 0.05–0.93). Higher risk of SSI was found in cases not performed by the abdominal wall reconstruction group OR 13.6 (CI 95% 9.12–15.5). In terms of hernia relapse, we have 12% of cases; all of them over a year after the surgery.
Conclusions
TAR procedure for complex abdominal wall defects under specific clinical conditions including emergency scenarios is viable. Specialized and experienced groups show lessen surgical site occurrences; further studies are needed to confirm our results.