bluuebunny/crossref_metadata_2025_split huggingface dataset:
PENGEMBANGAN KEMAMPUAN PEMAHAMAN MATEMATIK MENGGUNAKAN MOODLE DENGAN DISCOVERY LEARNING DALAM PEMBELAJARAN MATEMATIKA SECARA DARING
Authors: Widianingrum Evi , Purwaningrum Jayanti Putri 
Published: April 2022

Kajian ini dilatar belakangi oleh kemampuan pemahaman matematik belajar (understanding) siswa yang masih rendah, baik siswa Sekolah Menengah Pertama. Kemampuan pemahaman matematik (understanding) dalam pembelajaran daring perlu dikembangkan bagi siswa agar mampu memahami penjelasan materi matematika. Pada pembelajaran daring siswa banyak yang merasa kesulitan dalam pelaksanaan pembelajaran. Untuk mengatasi hal tersebut pembelajaran daring dengan kemampuan pemahaman matematik diperlukan juga media dan model pembelajaran yang tepat dalam proses belajar pembelajaran agar lebih efektif. Alternatif media pembelajaran yang digunakan yaitu media berbasis moodle. Dengan media berbasis moodle siswa akan lebih mudah dalam proses belajar. Secara online, pembelajaran matematika dapat diakses dimanapun sehingga bersifat efektif dan fleksibel. Sedangkan, model pembelajaran yang diterapkan yaitu model pembelajaran discovery learning. Melalui model pembelajaran discovery learning siswa akan lebih aktif dalam proses belajarnya. Hal ini dapat disimpulkan bahwa kemampuan pemahaman matematik siswa dalam pembelajaran daring akan lebih baik jika menggunakan media berbasis moodle dan dengan model pembelajaran discovery learning.
KAJIAN TEORI TENTANG PEMBELAJARAN OPERASI ARITMATIKA MELALUI PERMAINAN
Authors: Ariskha Yulia Devi , Hartati Sulis Janu , Prastiwi Lusiana 
Published: April 2022

ABSTRAK
Penelitian ini bertujuan untuk mengetahui permainan tradisional congklak dan permainan ular tangga mampu meningkatkan kemampuan berhitung siswa. Metode yang digunakan dalam penelitian ini adalah penelitian kualitatif dengan jenis penelitian kajian pustaka atau studi literatur atau library research. Sumber data diperoleh dari pustaka atau literatur yang berasal dari jurnal dan skripsi yang dipublikasikan terdiri dari 17 jurnal dan 3 skripsi. Instrumen penelitian yang digunakan yakni penelit sendiri (human instrument). Teknik pengumpulan data yang digunakan adalah melakukan editing, organizing dan finding. Teknik analisis data yang digunakan yakni menggunakan teknik analisis isi dan teknik deduktif. Prosedur penelitian yang digunakan adalah memilih topik penelitian, eksplorasi informasi, menentukan fokus penelitian, mengumpulkan sumber data, mempersiapkan penyajian data penelitian dan Menyusun laporan penelitian.Hasil penelitian ini menunjukkan bahwa penggunaan media permainan tradisional congklak dan permainan ular tangga mampu meningkatkan kemampuan berhitung siswa. Pembelajaran operasi aritmatika melalui permainan akan membuat siswa merasa senang dan juga dapat dengan mudah memahami materi yang diajarkan oleh guru.
Kata Kunci: Pembelajaran berbasis Permainan, Berhitung, Matematika
Ectopic liver and hepatocellular carcinoma
Authors: Helic Bakir , Helic Larisa , Osmic Hajrudin 
Published: April 2022

Abnormal location of liver tissue or ectopic liver is a rare anomaly that is usually found on gallbladder, but as this tissue if functionally handicapped it is susceptible to hepatocarcinogenesis. In this article, we present data about case reports of ectopic liver published from 2004 to 2020, about the connection between hepatocellular carcinoma and ectopic liver, its location, and the reason for a visit to a medical professional.
Quality of life of caregivers of patients with gastrointestinal cancer: relationship of sex, age, and stage of the cancer patients
Authors: Rosa Lilian Nascimento , Forones Nora Manoukian 
Published: April 2022

ABSTRACT
Introduction: The caregivers of cancer patients may experience changes in their routine that affect their quality of life. The aim of the study was to identify the domains that compromise the quality of life (QoL) of the caregivers of patients with gastrointestinal cancer (GIC).
Methods: A descriptive, observational study with caregivers of patients diagnosed with GIC during chemotherapy therapy was done. The caregivers answered 2 questionnaires, SF-36 (short form health survey 36) and CBS (caregiver burden scale).
Results: 100 caregivers of 100 patients with GIC were included. The mean age of the patients was 62.2±13 years. Most of them had colorectal cancer (66%), ECOG 0-1 (87%) and stage II/III (81%) disease. Among caregivers, 81% had less than 60 years old and 76% were female. According to the SF-36, lower levels were observed in the emotional, physical aspects and vitality and the best average in functional capacity. Regarding the CBS instrument, the general strain domain and disappointment was the more affected. Stage or ECOG was not associated to the caregivers QOL or burden. High schooling level of the patients was associated with a better quality of life and less burden of the caregivers. Ageing caregivers had a worst QoL and an increased burden.
Conclusion: Most of caregivers were women and youngers, and had a worst quality of life in emotional role, physical aspects and vitality, and an increased burden in general strain and disappointment.
Clinical and sociodemographic profile of patients with cutaneous melanoma attended at an oncology referral hospital in Florianópolis between 2013 and 2017
Authors: Silveira Matheus Beltrami , Baptista Tamise da Silva , Oenning da-Gama Fabiana , Izidoro Andressa Moretti 
Published: April 2022

ABSTRACT
Introduction: Cutaneous melanoma is the most lethal skin cancer and its incidence has significantly increased in recent years. In particular, Florianópolis is the Brazilian capital with the highest incidence of the disease.
Objective: To investigate the clinical and sociodemographic profile of patients with cutaneous melanoma treated at a public oncology referral hospital in Florianópolis from 2013 to 2017.
Methods: This is a descriptive and cross-sectional study carried out at the Santa Catarina Oncology Research Center (Centro de Pesquisas Oncológicas - CEPON). It included 468 patients diagnosed with melanoma skin cancer (ICD-O, 3rd edition C44 - skin melanoma) evaluated between 2013 and 2017. Data collection was performed by accessing the hospital cancer registry and electronic and physical medical records. The data were plotted in a Windows Excel spreadsheet and analyzed using the Statistical Package for the Social Sciences (SPSS) software.
Results: There was a slight predominance of females, white-skinned, with a mean age of 54.3 years old at the time of diagnosis. The most prevalent primary tumor site was the trunk. Superficial spreading melanoma was the most frequent condition, and ulceration was absent in most cases. Clinical stage IV was the most common, and lungs and bronchi were the main metastasis sites. The most performed treatment was wide local excision and the most widely used systemic therapy was chemotherapy.
Conclusion: This study characterized the sociodemographic and clinical profile of patients diagnosed with cutaneous melanoma and treated at a referral hospital in the Brazilian capital with the highest skin cancer rates.
The addition of PD-1/PD-L1 axis blockade to BRAF and MEK inhibition for advanced melanoma patients harboring BRAF mutations: a systematic review and meta-analysis
Authors: Ribeiro Mauricio Fernando Silva Almeida , Xavier Camila Bragança , Pereira Allan Andresson Lima , Scaranti Mariana , Faria Luiza Dib Batista Bugiato , Correa Tatiana Strava , Sahade Marina , Muniz David Queiroz Borges , Feher Olavo , Fernandes Gustavo dos Santos , Katz Artur , Munhoz Rodrigo Ramella 
Published: April 2022

ABSTRACT
Objectives: Immune-checkpoint inhibitors (ICI) and targeted-therapies (TT) have become standard options for BRAF-V600 metastatic melanomas (MM). Recently, randomized trials (RCT) addressed the efficacy of combined approaches, with conflicting results. We sought to evaluate efficacy and safety of first-line combination ICI and BRAF/MEK inhibitors (triplets) versus BRAF/MEKi (doublets).
Methods: We performed a systematic review and metaanalysis of RCT comparing triplet versus doublet published in MEDLINE and EMBASE from 2016-September/2020. We obtained pooled effect estimates through random-effects model assuming p<0.05 as statistically significant.
Results: Among 1,784 studies, 3 RCT were selected. Triplets demonstrated progression-free survival (PFS) (HR 0.79 - CI 0.68-0.91, p=0.001) and overall survival (OS) improvement (HR 0.81 - CI 0.67-0.98, p=0.03), with increased rates of grades 3/4 adverse events (AEs), any grade pyrexia, arthralgia, and aminotransferases elevation. AEdiscontinuation rates of all drugs remained similar.
Conclusions: Triplets improved PFS and OS with manageable toxicities. These are preliminary results and mature data are expected.
Cross-sectional study of 1-to-5- year head and neck cancer survivors
Authors: Cruvinel Pedro Bastos , Pereira Raony Molim de Sousa , Fressatti André Luiz de Macedo , Motta Bianka Jurca Gonçalves-da , Motta Ana Carolina Fragoso , Oliveira Harley Francisco de , Ricz Hilton Marcos Alves , Macedo Leandro Dorigan de , Tirapelli Camila 
Published: April 2022

ABSTRACT
Objectives: This study aimed to determine the demographic and clinical profile of 1-to-5year head and neck cancer (HNC) survivors, and they oral features that could affect QoL.
Material and Methods: In this cross-sectional study, medical records of 184 were reviewed concerning demographic, clinical and tumour characteristics. 40 of them underwent a quality of life (QoL) questionnaire and assessment of xerostomia (XA), using the oral health impact profile -14 (OHIP-14) and the xerostomia inventory (XI). Salivary flow was determined by measurement of stimulated whole salivary flow rate (SWSFR) and the number of teeth (NT) by determining the number of extracted and/or lost teeth. One-sample t-test, absolute and relative frequencies and Spearman's correlation test was used for statistical analysis of data.
Results: Most HNC patients were male, aged between 50 and 60 years, alcohol and tobacco users, with low educational attainment, several comorbidities, and pharyngeal tumours. The high scores in the OHIP-14 (23.82±14.0) and XI (39.2±7.6) indicated that most patients had their QoL adversely affected and had xerostomia. Mean SWSFR was 0.2mL/ min, and 15% (n=28) of patients were edentulous. The Spearman test showed a significant correlation between QoL and xerostomia, and salivary flow and QoL.
Conclusion: This study evaluated characteristics of head and neck cancers (HNC) concerning demographic, clinical and tumour characteristics, quality of life (QoL), xerostomia, salivary flow, and number of teeth (NT) through an observational and cross-sectional study.
Impacto de la pandemia de la COVID-19 sobre la enseñanza universitaria: estudio del caso de Estadística Empresarial II en la Universidad Pablo de Olavide
Authors: Chaves Maza Manuel , Márquez Durán Antonio Miguel , Romano Paguillo Inmaculada , Sánchez-Sánchez Francisca J. 
Published: April 2022

La pandemia de la COVID 19 ha afectado de forma notable a las Universidades, provocando y acelerando cambios que afectan a todos los ámbitos. Entre estas modificaciones, la docencia ha tenido que realizar importantes variaciones metodológicas, asumiendo una mayor presencia tecnológica. En este marco, el objetivo del estudio es analizar el impacto provocado por estos cambios en la asignatura de Estadística Empresarial II (EEII), impartida en las titulaciones del Grado en Administración y Dirección de Empresas (GADE) y el Doble Grado en Derecho y Administración y Dirección de Empresas (XAYD) en la Universidad Pablo de Olavide de Sevilla. Se comprueba que las modificaciones introducidas en la asignatura, provocan un efecto negativo sobre los resultados académicos, tanto en el número de presentados como en el de aprobados.
Abstract
The COVID-19 pandemic has noticeably affected Universities, provoking and accelerating changes in every field. Among these modifications, teaching has gone through significant methodological changes, assuming a larger technological presence. Regarding this, the main purpose of this paper is to analyze the impact of these alterations on the subject Statistics for Business II, taught in Degree in Business Administration and Management and Double Degree in Business Administration and Management and Law, at Pablo de Olavide University in Seville. The changes introduced in this subject have been proved to negatively affect its academic results, both in the number of students who took the final tests as well as the number of those who passed it.
Impact Assessment of Soil Parameters Affected by Gas Flaring in Tea Garden in Dibrugarh District of Assam, India
Authors: Phukan Ripsita , Sahewalla Indra Prasad 
Published: April 2022

The gas flare is considered as the challenging and environmental problem and hence this experiment was taken to study the physical and chemical properties of soil of tea garden effected by gas flare located in south of Kothaloni OCS in Dibrugarh district of Assam during September 2019- March 2020. The design selected was Randomized Complete Block Design (RCBD). The soil samples were collected from (40-50) metres, (50-60) metres, (60-70) metres, (70-80) metres and control site (150-160) metres away from the flare site in two different seasons namely autumn and rainy seasons. Soil physical parameters such as soil temperature, soil moisture ,bulk density, porosity, hydraulic conductivity and soil chemical parameters sucha as pH, organic carbon content, electrical conductivity, available nutrients (NPK) were studied. Soil temperature recorded highest (29.83°C) at distance (40-50) metres away from the gas flaring site and decreased with its increased distances from the flaring site while soil moisture recorded lowest (11.48%) at distance (40-50) metres which increased with far away distances from the flaring site. Rest of the studied soil parameters viz., bulk density, porosity, hydraulic conductivity, pH, organic carbon content, electrical conductivity and available nutrients (NPK) recorded non significant variations along distances and seasons.
The Economic Burden of Antibiotic Resistance Based on Anti-microbial Susceptibility Tests in Various Infections in a Tertiary Care Hospital: A Prospective Study
Authors: Lavanya M. A. , Nizamudeen Khadeeja , J. S. Parvathy , Dharman Dhanya , S. Dharan Shaiju. 
Published: April 2022

Introduction: Antibiotics are anti-microbial agents used for the treatment of various bacterial infections. Excessive use, inappropriate prescription pattern conduct to antibiotic resistance (AR). Antibiotic resistance leads to an increase in the cost of medical care. Our study assess the economic burden due to antibiotic resistance based on antimicrobial susceptibility testing in different infections.
Methods: The data for the study was collected prospectively and recorded in a data collection form specially designed for the study based on inclusion and exclusion criteria obtained from the Department of General Medicine, NIMS Hospital, Neyyattinkara, Thiruvananthapuram of patients with infectious diseases during the period of 6 months from April 2021 to September 2021.
Results: 128 patients were studied, 53.1% (n=68) were males and 46.9% (n=60) were females and the most frequent age range was between 46-60 years of age (35%, n=45).The most common infection seen in patients was urinary tract infection (20.3%, n=26). The socioeconomic status, (50%, n=64) belonged to lower- middle class. Antibiotic sensitivity test was done in (52.3%, n=67) and the patients with resistance (Rs.26530.81) had more mean cost than those without resistance (Rs.18412.01) showing highly significant difference (p=0.001). The resistant patients without antibiotic sensitivity testing had (Rs.30193.14).
Conclusion: Our study demonstrated that the resistant patients without antibiotic sensitivity testing had a significantly higher financial burden. Therefore, we strongly recommend to perform antibiotic sensitivity testing (AST) in patients with infectious diseases. Also, patient should be well-informed about the details and the results of antibiotic sensitivity testing to ensure medication adherence and to avoid self- medication.
Response of Lettuce Cultivars to Inoculation with Trichoderma spp.
Authors: Lima Rejayne Barbosa , Cabral Cleia Santos , Silva Lincon Rafael da , De Melo Luis Alberto Martins Palhares , Muniz Paulo Henrique Pereira Costa , Mello Sueli Corrêa Marques de 
Published: April 2022

Fungi of the Trichoderma genus are present in practically all types of soil and they have the ability to establish a beneficial relationship with plants. In addition to acting as direct biological control agents, they also act as plant growth promoters, by an indirect biological control mechanism. Because of these, many products containing Trichoderma strains are used to improve seed health, providing better development of roots and aerial parts of plants. In view of this fact, research work was carried out in a greenhouse with the aim of evaluating the effect of five Trichoderma strains, belonging to the species T. virens, T. asperellum, T. asperelloides, in addition to a strain unidentified at the species level T. koningiopsis, in three new crisp lettuce cultivars (BRS Lélia, BRS Leila, and BRS Mediterrânea). A conidial suspension of each of the strains was prepared (1.0 x 107 conidia mL-1) and applied at the time of sowing the lettuce in pots. The experiment was completely randomized in a factorial 5x3 design (Trichoderma spp. x cultivars). Control treatments consisted of pots containing plants without any of the fungi. All Trichoderma strains applied increased fresh mass and length of root, fresh mass of aerial part and lettuce height in comparison to the controls treated just with water. The cultivar BRS Leila showed an increase of 44% in fresh root mass, 45% in fresh mass of aerial part, with T. virens; 15% in plant height with T. koningiopsis, and 23.94% in root length, with Trichoderma sp. For ‘BRS Lélia’ the highest values ​​of fresh root mass, fresh mass of aerial part and root length were 30%, 36.71%, and 13.33% with T. asperellum. Trichoderma asperelloides provided 13.72% increase in height compared to the control. ‘BRS Mediterrânea’ showed increments of 75% of fresh root mass, 78.45% of fresh mass of aerial part, and 44.37% of height with T. virens. With T. asperelloides, 40.61% was observed in root length. The strain T. virens performed better in all the analyzed variables, except for root length.
MEDIA SOSIAL SEBAGAI SARANA PENINGKATAN PENJUALAN UMKM KERAJINAN DI GRESIK
Authors: Laily Nur , Riharja Ikhsan Budi , Sidharta R Yudi , Aristianti R Widhi 
Published: April 2022

Pandemi mengajarkan banyak hal baru pada semua aspek kehidupan termasuk di dalamnya kegiatan bisnis. Pada saat sebelum pandemi kegiatan bisnis kerajinan dalam pemasarannya lebih banyak dilakukan secara konvensional yaitu bertemu langsung antara pelaku UMKM dengan konsumen. Pada awal sampai pertengahan pandemi pelaku UMKM masih belum terbiasa melakukan kegiatan bisnis secara online sehingga usaha yang dijalankan mengalami penurunan omset penjualan. Salah satu cara untuk mempertahankan bisnis melalui inovasi pemasaran produk dengan menggunakan sosial media yang dilengkapi dengan informasi produk yang singkat, padat, jelas dan menarik. Para pelaku UMKM merasa belum terbiasa dan kurang memahami cara pemasaran online yang tepat. Oleh karena itu pada kegiatan pengabdian masyarakat ini dilakukan kegiatan pelatihan pemasaran online dan pendampingan pembuatan media sosial sebagai sarana promosi yang baru. Kegiatan pendampingan ini dilakukan denga memanfaatkan media sosial seperti whatsapp, facebook, dan Instagram. Berdasarkan hasil evaluasi dan monitoring para pelaku merasa lebih nyaman menggunakan whatsapp status dalam memasarkan produknya di-bandingkan dengan menggunakan facebook dan Instagram. Menurut pelaku UMKM menggunakan whatsapp status jauh lebih mudah, efektif dan efisien karena dengan hanya membuka whatsapp pelaku UMKM dapat langsung berkomunikasi dengan calon pembeli maupun dengan pihak lainnya. Satu aplikasi semua kegiatan dapat dilakukan sehingga dirasa lebih efektif dan efisien dari sisi waktu.
Exploring the contributing factors to multiple chemical sensitivity in patients with migraine
Authors: Suzuki Keisuke , Okamura Madoka , Haruyama Yasuo , Suzuki Shiho , Shiina Tomohiko , Kobashi Gen , Hirata Koichi 
Published: April 2022

Abstract

Objective
Multiple chemical sensitivity (MCS) is a form of chemical intolerance in which various systemic symptoms are triggered by exposure to a variety of chemical substances. Although migraine has been associated with central sensitivity syndrome, the relationship between MCS and migraine has not been studied. We assessed the frequency of MCS and its related factors in patients with migraine.

Methods
We performed a cross-sectional study that included 95 patients (14 M/81 F; age, 45.4 ± 12.4 years) out of 100 consecutive patients with migraine from our outpatient headache clinic. MCS was defined as having a combination of Q1 ≥ 30, Q3 ≥ 13, and Q5 ≥ 17 on the quick environment exposure sensitivity inventory (QEESI; Japanese version). Central sensitization inventory-A scores &gt;40 were considered an indication of central sensitization. Headache-related disability and psychological distress were evaluated with the Migraine Disability Assessment score (MIDAS) and Kessler Psychological Distress Scale (K6), respectively.

Results
MCS was identified in 20% of patients with migraine; however, none had previously been diagnosed with MCS. The MCS-positive group had higher rates of photophobia, osmophobia, visual aura, sensory aura, and central sensitization and higher MIDAS and K6 scores than the MCS-negative group. A logistic regression analysis showed that osmophobia, sensory aura, and central sensitization were significant contributors to MCS.

Conclusion
We showed that MCS was observed in 20% of patients with migraine, and our study results may indicate a possible association of MCS with central sensitization and hypersensitivity-related symptoms in patients with migraine.