bluuebunny/crossref_metadata_2025_split huggingface dataset:
Free water corrected diffusion tensor imaging discriminates between good and poor outcomes of comatose patients after cardiac arrest
Authors: Keijzer Hanneke M. , Duering Marco , Pasternak Ofer , Meijer Frederick J. A. , Verhulst Marlous M. L. H. , Tonino Bart A. R. , Blans Michiel J. , Hoedemaekers Cornelia W. E. , Klijn Catharina J. M. , Hofmeijer Jeannette 
Published: November 2022

Abstract
Objectives
Approximately 50% of comatose patients after cardiac arrest never regain consciousness. Cerebral ischaemia may lead to cytotoxic and/or vasogenic oedema, which can be detected by diffusion tensor imaging (DTI). Here, we evaluate the potential value of free water corrected mean diffusivity (MD) and fractional anisotropy (FA) based on DTI, for the prediction of neurological recovery of comatose patients after cardiac arrest.

Methods
A total of 50 patients after cardiac arrest were included in this prospective cohort study in two Dutch hospitals. DTI was obtained 2–4 days after cardiac arrest. Outcome was assessed at 6 months, dichotomised as poor (cerebral performance category 3–5; n = 20) or good (n = 30) neurological outcome. We calculated the whole brain mean MD and FA and compared between patients with good and poor outcomes. In addition, we compared a preliminary prediction model based on clinical parameters with or without the addition of MD and FA.

Results
We found significant differences between patients with good and poor outcome of mean MD (good: 726 [702–740] × 10-6 mm2/s vs. poor: 663 [575–736] × 10-6 mm2/s; p = 0.01) and mean FA (0.30 ± 0.03 vs. 0.28 ± 0.03; p = 0.03). An exploratory prediction model combining clinical parameters, MD and FA increased the sensitivity for reliable prediction of poor outcome from 60 to 85%, compared to the model containing clinical parameters only, but confidence intervals are overlapping.

Conclusions
Free water-corrected MD and FA discriminate between patients with good and poor outcomes after cardiac arrest and hold the potential to add to multimodal outcome prediction.

Key Points
• Whole brain mean MD and FA differ between patients with good and poor outcome after cardiac arrest.
• Free water-corrected MD can better discriminate between patients with good and poor outcome than uncorrected MD.
• A combination of free water-corrected MD (sensitive to grey matter abnormalities) and FA (sensitive to white matter abnormalities) holds potential to add to the prediction of outcome.
Finite-Data Error Bounds for Koopman-Based Prediction and Control
Authors: Nüske Feliks , Peitz Sebastian , Philipp Friedrich , Schaller Manuel , Worthmann Karl 
Published: November 2022

AbstractThe Koopman operator has become an essential tool for data-driven approximation of dynamical (control) systems, e.g., via extended dynamic mode decomposition. Despite its popularity, convergence results and, in particular, error bounds are still scarce. In this paper, we derive probabilistic bounds for the approximation error and the prediction error depending on the number of training data points, for both ordinary and stochastic differential equations while using either ergodic trajectories or i.i.d. samples. We illustrate these bounds by means of an example with the Ornstein–Uhlenbeck process. Moreover, we extend our analysis to (stochastic) nonlinear control-affine systems. We prove error estimates for a previously proposed approach that exploits the linearity of the Koopman generator to obtain a bilinear surrogate control system and, thus, circumvents the curse of dimensionality since the system is not autonomized by augmenting the state by the control inputs. To the best of our knowledge, this is the first finite-data error analysis in the stochastic and/or control setting. Finally, we demonstrate the effectiveness of the bilinear approach by comparing it with state-of-the-art techniques showing its superiority whenever state and control are coupled.
Changes in fatty acid levels after consumption of a novel docosahexaenoic supplement from algae: a crossover randomized controlled trial in omnivorous, lacto-ovo vegetarians and vegans
Authors: García-Maldonado Elena , Alcorta Alexandra , Zapatera Belén , Vaquero M. Pilar 
Published: November 2022

Abstract
Purpose
To determine serum fatty acids of lacto-ovo vegetarian (LOV), vegan (VEG) and omnivorous (OMN) adults, and to analyse the effects of consuming a docosahexaenoic acid (DHA) supplement of vegetable origin on fatty acid profile.

Methods
A randomized, double-blind, placebo-controlled crossover design was conducted in healthy adults. Volunteers (n = 116) were randomly assigned to a DHA-supplement (dose 250 mg/day), made from the microalgae Schizochytrium sp., or a placebo during 5-week periods separated by a 5-week washout interim period. Compliance and dietary intake were estimated and serum fatty acids were determined by gas chromatography. Results were analysed by mixed linear models.

Results
Percentage of linoleic acid (C18:2n6) in serum was the highest among the fatty acids in the three diet groups, followed by oleic (C18:1n9) and palmitic (C16:0) acids. Linoleic (C18:2n6) and alpha-linolenic (C18:3n3) acids were higher in VEG compared to OMN (p < 0.001), while in LOV, their levels were intermediate between the other groups. Women presented higher DHA (C22:6n3) than men (p < 0.001). The DHA-supplement increased serum DHA compared to placebo in the three diet groups (p < 0.001), and a higher increase was observed in VEG followed by LOV (p < 0.001). The ratio serum n-6/n-3 improved by the supplementation but remained higher in LOV and VEG than in OMN. In contrast, the DHA-supplement decreased docosapentaenoic (C22:5n3) and docosatetraenoic (C22:4n6) acids in all diet groups (p < 0.001) and increased the eicosapentaenoic to alpha-linolenic fatty acids ratio (p = 0.016).

Conclusion
The DHA-supplement at dose of 250 mg/day was effective in increasing serum DHA either in omnivorous, lacto-ovo vegetarian and vegan adults.

Clinical trial registration
Registered at Clinicaltrials.gov (www.clinicaltrials.gov), NCT04278482.
Survival of sharp force trauma in burnt bones: effects of environmental factors
Authors: Vachirawongsakorn Vijarn , Márquez-Grant Nicholas , Painter Jonathan 
Published: November 2022

Abstract
This study investigates how environmental variables, such as temperature and rainfall, affect previously induced cut marks on burnt bones. This research used non-serrated and serrated blade knives to inflict trauma on Sus scrofa ribs (n = 240). The bones were later burnt and left for 1 month in a taphonomic experimental facility. Qualitative and quantitative examinations were conducted using macroscopic and microscopic techniques to assess specific characteristics of the cut marks. Any changes to the dimension and morphology of the cut marks as well as their level of fragmentation were recorded.This study has led to three important outcomes: (1) identification of pre-existing cut marks is possible in reconstructed burnt bone fragments; (2) cut marks from different types of knife blades showed dissimilar responses to heat and the environment; and (3) specific environmental variables affect burnt bone fragmentation. These results have implications for trauma analysis on burnt remains in forensic anthropology casework.
Multidomain cognitive impairment in non-hospitalized patients with the post-COVID-19 syndrome: results from a prospective monocentric cohort
Authors: Schild Ann-Katrin , Goereci Yasemin , Scharfenberg Daniel , Klein Kim , Lülling Joachim , Meiberth Dix , Schweitzer Finja , Stürmer Sophie , Zeyen Philip , Sahin Derya , Fink Gereon R. , Jessen Frank , Franke Christiana , Onur Oezguer A. , Kessler Josef , Warnke Clemens , Maier Franziska 
Published: November 2022

Abstract
Background
A fraction of patients with asymptomatic to mild/moderate acute COVID-19 disease report cognitive deficits as part of the post-COVID-19 syndrome. This study aimed to assess the neuropsychological profile of these patients.

Methods
Assessment at baseline (three months or more following acute COVID-19) of a monocentric prospective cohort of patients with post-COVID-19 syndrome. Multidomain neuropsychological tests were performed, and questionnaires on depression, anxiety, fatigue, sleep, and general health status were administered.

Results
Of the 58 patients screened, six were excluded due to possible alternative causes of cognitive impairment (major depression, neurodegenerative disease). Of the remaining 52 individuals, only one had a below-threshold screening result on Mini-Mental State Examination, and 13 scored below the cut-off on Montreal Cognitive Assessment. Extended neuropsychological testing revealed a neurocognitive disorder (NCD) in 31 (59.6%) participants with minor NCD in the majority of cases (n = 26). In patients with NCD, the cognitive domains learning/memory and executive functions were impaired in 60.7%, complex attention in 51.6%, language in 35.5%, and perceptual-motor function in 29.0%. Cognitive profiles were associated with daytime sleepiness but not with depression, anxiety, sleep quality, total general health status, or fatigue.

Conclusion
Neurocognitive impairment can be confirmed in around 60% of individuals with self-reported deficits as part of post-COVID-19 syndrome following a mild acute COVID-19 disease course. Notably, screening tests cannot reliably detect this dysfunction. Standard psychiatric assessments showed no association with cognitive profiles. Longitudinal studies are needed to further evaluate the course of neurocognitive deficits and clarify pathophysiology.
Smartphone video nystagmography using convolutional neural networks: ConVNG
Authors: Friedrich Maximilian U. , Schneider Erich , Buerklein Miriam , Taeger Johannes , Hartig Johannes , Volkmann Jens , Peach Robert , Zeller Daniel 
Published: November 2022

AbstractBackgroundEye movement abnormalities are commonplace in neurological disorders. However, unaided eye movement assessments lack granularity. Although videooculography (VOG) improves diagnostic accuracy, resource intensiveness precludes its broad use. To bridge this care gap, we here validate a framework for smartphone video-based nystagmography capitalizing on recent computer vision advances.MethodsA convolutional neural network was fine-tuned for pupil tracking using > 550 annotated frames: ConVNG. In a cross-sectional approach, slow-phase velocity of optokinetic nystagmus was calculated in 10 subjects using ConVNG and VOG. Equivalence of accuracy and precision was assessed using the “two one-samplet-test” (TOST) and Bayesian interval-null approaches. ConVNG was systematically compared to OpenFace and MediaPipe as computer vision (CV) benchmarks for gaze estimation.ResultsConVNG tracking accuracy reached 9–15% of an average pupil diameter. In a fully independent clinical video dataset, ConVNG robustly detected pupil keypoints (median prediction confidence 0.85). SPV measurement accuracy was equivalent to VOG (TOSTp < 0.017; Bayes factors (BF) > 24). ConVNG, but not MediaPipe, achieved equivalence to VOG in all SPV calculations. Median precision was 0.30°/s for ConVNG, 0.7°/s for MediaPipe and 0.12°/s for VOG. ConVNG precision was significantly higher than MediaPipe in vertical planes, but both algorithms’ precision was inferior to VOG.ConclusionsConVNG enables offline smartphone video nystagmography with an accuracy comparable to VOG and significantly higher precision than MediaPipe, a benchmark computer vision application for gaze estimation. This serves as a blueprint for highly accessible tools with potential to accelerate progress toward precise and personalized Medicine.
A hybrid meshless–statistical energy analysis method for complex structure vibration analysis
Authors: Tan Puxue , Fichera Sebastiano , Batou Anas 
Published: November 2022

AbstractA new hybrid deterministic–statistical energy analysis (SEA) formulation is presented by introducing a meshless method for modeling the deterministic components. Moving least square Ritz (MLSR) meshless method is applied, in which MLS is used to build the discrete model and the Ritz method allows to obtain variational formulation of the deterministic components of the governing equations. Such governing equations can be formulated via boundary conditions by penalty method and Lagrange multipliers. The hybrid model by penalty method keeps a similar formulation with the framework of the finite element SEA, while the model by the latter increases the size of the dynamic stiffness matrix and the expanded components are determined by the constraints. For validation purpose, three case studies are provided, including beam–coupled plates and plate–coupled plates built-up structure. The results by the hybrid MLSR-SEA model are compared with those by FE-SEA and Monte Carlo simulation. Good agreements of responses between the methods demonstrate the reliability of the MLSR-SEA formulation.
Changes in miRNA expression in patients with peripheral arterial vascular disease during moderate- and vigorous-intensity physical activity
Authors: Sieland Johanna , Niederer Daniel , Engeroff Tobias , Vogt Lutz , Troidl Christian , Schmitz-Rixen Thomas , Banzer Winfried , Troidl Kerstin 
Published: November 2022

Abstract
Background
Walking is the preferred therapy for peripheral arterial disease in early stage. An effect of walking exercise is the increase of blood flow and fluid shear stress, leading, triggered by arteriogenesis, to the formation of collateral blood vessels. Circulating micro-RNA may act as an important information transmitter in this process. We investigated the acute effects of a single bout of 1) aerobic walking with moderate intensity; and 2) anaerobic walking with vigorous intensity on miRNA parameters related to vascular collateral formation.

Methods
Ten (10) patients with peripheral arterial disease with claudication (age 72 ± 7 years) participated in this two-armed, randomized-balanced cross-over study. The intervention arms were single bouts of supervised walking training at (1) vigorous intensity on a treadmill up to volitional exhaustion and (2) moderate intensity with individual selected speed for a duration of 20 min. One week of washout was maintained between the arms. During each intervention, heart rate was continuously monitored. Acute effects on circulating miRNAs and lactate concentration were determined using pre- and post-intervention measurement comparisons.

Results
Vigorous-intensity walking resulted in a higher heart rate (125 ± 21 bpm) than the moderate-intensity intervention (88 ± 9 bpm) (p < 0.05). Lactate concentration was increased after vigorous-intensity walking (p = 0.005; 3.3 ± 1.2 mmol/l), but not after moderate exercising (p > 0.05; 1.7 ± 0.6 mmol/l). The circulating levels of miR-142-5p and miR-424-5p were up-regulated after moderate-intensity (p < 0.05), but not after vigorous-intensity training (p > 0.05).

Conclusion
Moderate-intensity walking seems to be more feasible than vigorous exercises to induce changes of blood flow and endurance training-related miRNAs in patients with peripheral arterial disease. Our data thus indicates that effect mechanisms might follow an optimal rather than a maximal dose response relation. Steady state walking without the necessity to reach exhaustion seems to be better suited as stimulus.
Trends in comorbid physical and mental health conditions in children from 1999 to 2017 in England
Authors: Panagi Laura , Newlove-Delgado Tamsin , White Simon R. , Bennett Sophie , Heyman Isobel , Shafran Roz , Ford Tamsin 
Published: November 2022

Abstract
Introduction
Children with long-term physical health conditions (pLTCs) are at increased risk of mental health conditions but less is known about time trends in the mental health of this group of children.

Methods
We used data from three comparable, population-based surveys of children conducted in 1999, 2004, and 2017. We examined whether the proportion of children aged 5–15 years old with comorbid mental health conditions (measured using the multi-informant Development and Well-being Assessment tool) and pLTCs (measured using parental report) in England increased from 1999 to 2017 using linear regression analysis.

Results
Our analysis used data from 8662 (1999), 6401 (2004) and 6219 (2017) children, respectively. The proportion of children with comorbid pLTCs and psychiatric disorders was 0.050 (95% CI = 0.045, 0.055) in 1999, 0.054 (95% CI = 0.049, 0.060) in 2004, and 0.059 (95% CI = 0.053, 0.065) in 2017. The linear regression model revealed a non-significant effect of time on the proportion of children with comorbid pLTCs and psychiatric disorders from 1999 to 2017 (B = 0.0004785; SE = 0.0001256; p = 0.163).

Conclusion
The estimated prevalence of school-aged children with comorbid pLTCs and mental health conditions in England remained stable since 1999, highlighting the need to prioritize mental health resources for children with physical health comorbidities.
Hydrodynamics of karst aquifers in metamorphic carbonate rocks: results from spring monitoring in the Apuan Alps (Tuscany, Italy)
Authors: Piccini Leonardo , Nannoni Alessia , Poggetti Emilio 
Published: November 2022

AbstractDuring the last 40 years, extensive research has characterized the hydrogeology of many karst aquifers, as they are important water resources. Despite that, a systematic investigation on metamorphic karst aquifers is still lacking. The present study investigates the functioning of marble karst aquifers by means of spring hydrological monitoring, coupled with storm-hydrograph, thermograph, and chemograph (HTC) analysis and lag time analysis. Renara and Equi springs (Apuan Alps, Italy) were selected for this investigation. These springs drain catchments that have different degrees of structural complexity. Piston flow is the common hydrodynamic response of Renara spring to infiltration. Strong dilution effects were observed only during the heaviest rainfall events. Prolonged dry conditions after a sustained recharge phase showed the delayed arrival of infiltration water about a month later. Equi spring has a more complex behaviour due to its wider and more hydrologically heterogeneous catchment but the comparison of HTC graphs during the winter dry phase helped to recognize the differential contributions of proximal and distal sectors. Both springs show a rapid discharge increase in response to impulse infiltrative events. Conversely, water temperature and specific electrical conductivity increase only slightly during floods, indicating limited chemical and thermal exchanges between the rock and the water stored in these aquifers. The hydrodynamic behaviour of these karst springs suggests that the Apuan metamorphic aquifers are characterized by the predominance of conduit porosity over fissure and matrix porosities. This is explained by a reduced interstitial porosity and fracturing of the metamorphic carbonate rocks.
Excess costs of multiple sclerosis: a register-based study in Sweden
Authors: Murley Chantelle , Tinghög Petter , Teni Fitsum Sebsibe , Machado Alejandra , Alexanderson Kristina , Hillert Jan , Karampampa Korinna , Friberg Emilie 
Published: November 2022

AbstractBackground and objectivePopulation-based estimates of the socioeconomic burden of multiple sclerosis (MS) are limited, especially regarding primary healthcare. This study aimed to estimate the excess costs of people with MS that could be attributed to their MS, including primary healthcare.MethodsAn observational study was conducted of the 2806 working-aged people with MS in Stockholm, Sweden and 28,060 propensity score matched references without MS. Register-based resource use was quantified for 2018. Annual healthcare costs (primary, specialised outpatient, and inpatient healthcare visits along with prescribed drugs) and productivity losses (operationalised by sickness absence and disability pension days) were quantified using bottom-up costing. The costs of people with MS were compared with those of the references using independentt-tests with bootstrapped 95% confidence intervals (CIs) to isolate the excess costs of MS from the mean difference.ResultsThe mean annual excess costs of MS for healthcare were €7381 (95% CI 6991–7816) per person with MS with disease-modifying therapies as the largest component (€4262, 95% CI 4026–4497). There was a mean annual excess cost for primary healthcare of €695 (95% CI 585–832) per person with MS, comprising 9.4% of the excess healthcare costs of MS. The mean annual excess costs of MS for productivity losses were €13,173 (95% CI 12,325–14,019) per person with MS, predominately from disability pension (79.3%).ConclusionsThe socioeconomic burden of MS in Sweden from healthcare consumption and productivity losses was quantified, updating knowledge on the cost structure of the substantial excess costs of MS.
Usability and transparency in the design of a tool for automatic support for web accessibility validation
Authors: Iannuzzi Nicola , Manca Marco , Paternò Fabio , Santoro Carmen 
Published: November 2022

AbstractThe importance of guaranteeing accessible Web applications is becoming widely recognised, and supported by national and international legislation. This implies an increasing need for large scale validations, which can be achieved only through automatic support. Thus, there is a need for a new generation of accessibility validation tools able to check against the continuously evolving guidelines and report any issues revealed, considering that their results will be used by many people with varied backgrounds and goals. Such tools should be able to support monitoring of Web sites’ accessibility, provide user-friendly information suitable for various purposes, and be transparent in terms of what they are actually able to evaluate in order to elicit the right expectations from their users. They should also consider how the technologies for implementing Web sites have evolved in recent years. In this paper, we provide a description of the requirements and design dimensions that characterise such tools in order to address emerging needs, providing indications on whether and how several existing validation tools support them, and present how we have addressed and implemented them in a specific tool. We also report on a first usability test of such tool, which has provided encouraging feedback.