bluuebunny/crossref_metadata_2025_split huggingface dataset:
SARM1 is responsible for calpain-dependent dendrite degeneration in mouse hippocampal neurons
Authors: Miyamoto Takashi , Kim Chaeyoung , Chow Johann , Dugas Jason C , DeGroot Jack , Bagdasarian Alex L , Thottumkara Arun P , Larhammar Martin , Calvert Meredith EK , Fox Brian M , Lewcock Joseph W , Kane Lesley A 
Published: April 2022

AbstractSterile alpha and TIR motif containing 1 (SARM1) is a critical regulator of axon degeneration that acts through hydrolysis of NAD+following injury. Recent work has defined the mechanisms underlying SARM1’s catalytic activity and advanced our understanding of SARM1 function in axons, yet the role of SARM1 signaling in other compartments of neurons is still not well understood. Here we show in cultured hippocampal neurons that endogenous SARM1 is present in axons, dendrites and cell bodies and that direct activation of SARM1 by the neurotoxin Vacor causes not just axon degeneration, but degeneration of all neuronal compartments. In contrast to the axon degeneration pathway defined in dorsal root ganglia (DRGs), SARM1-dependent hippocampal axon degeneration in vitro is not sensitive to calpain inhibition whereas dendrite degeneration downstream of SARM1 is calpain-dependent in this cell type. This data indicates SARM1 plays a critical role in neurodegeneration outside of axons and elucidates divergent pathways leading to degeneration in hippocampal axons and dendrites.
Acceptability and Feasibility of Genetic Testing to Assess Risk of HIV-Associated Neurocognitive Impairment among Thai Adolescents and Young Adults
Authors: Santoro Anthony F. , Ferraris Christopher M. , Aghvinian Maral , Aurpibul Linda , Kolson Dennis , Robbins Reuben N. 
Published: April 2022

AbstractHost genetic factors may modify the risk of developing HIV-associated neurocognitive impairment (HIV-NCI), and genetic research has the potential to inform novel treatments for HIV-NCI. However, there is a need to better understand the acceptability of genetic testing among distinct populations of people living with HIV at increased risk for HIV-NCI, such as young people living with perinatally-acquired HIV (PHIV) in low- and middle-income countries (LMICs), to gauge the feasibility of genetic research within these populations. This pilot study evaluated the acceptability and feasibility of genetic testing to assess risk of future neurocognitive problems in fifty Thai adolescents and young adults (12-24 years; Mage=19.16; 52% female) with PHIV and demographically similar HIV-negative controls. Participants completed a survey assessing acceptability of and concerns about genetic testing and were asked to provide blood samples for genetic testing. Descriptive statistics and blood draw completion rates were produced and calculated. Reported concerns about genetic testing were grouped thematically and tallied. Independent t tests and chi-squares explored demographic differences between participants who reported concerns and peers. Results indicated 46 participants (92%) rated genetic testing as “acceptable” or “completely acceptable.” Eight participants (16%) reported concerns about genetic testing. The most common concerns were related to genetic information being shared or misused. Compared to peers, participants who reported concerns had more years of education and were more likely to have post-secondary schooling. Regarding completion rates, 49 participants (98%) agreed to genetic testing and provided blood samples. Overall, results support the acceptability and feasibility of incorporating genetic testing into research investigating HIV-NCI among adolescents and young adults in Thailand. Findings provide important considerations for planning future genetic studies among young people in Thailand and perhaps other LMICs.
Extended Effects of a Wearable Sensory Prosthesis on Gait, Balance Function and Falls After 26 Weeks of Use in Persons with Peripheral Neuropathy and High Fall Risk – The walk2Wellness Trial
Authors: Oddsson Lars IE , Bisson Teresa , Cohen Helen S , Iloputaife Ikechukwu , Jacobs Laura , Kung Doris , Lipsitz Lewis A , Manor Brad , McCracken Patricia , Rumsey Yvonne , Wrisley Diane M , Koehler-McNicholas Sara R 
Published: April 2022

AbstractBackgroundWe recently reported that individuals with impaired plantar sensation and high fall risk due to sensory peripheral neuropathy (PN) improved gait and balance function following 10 weeks of use of Walkasins®, a wearable lower limb sensory prosthesis that provides directional tactile stimuli related to plantar pressure measurements during standing and walking (RxFunction Inc., MN, USA). Here, we report 26-week outcomes and compare pre- and in-study fall rates. We expected improvements in outcomes and reduced fall rates reported after 10 weeks of use to be sustained.MethodsParticipants had clinically diagnosed PN with impaired plantar sensation, high fall risk (Functional Gait Assessment, FGA score <23) and ability to sense tactile stimuli above the ankle at the location of the device. Additional outcomes included 10m Gait Speed, Timed Up&Go (TUG), Four-Stage Balance Test, and self-reported outcomes, including Activities-Specific Balance Confidence scale and Vestibular Disorders Activities of Daily Living Scale. Participants tracked falls using a calendar.ResultsWe assessed falls and self-reported outcomes from 44 individuals after 26 weeks of device use; 30 of them conducted in-person testing of clinical outcomes. Overall, improvements in clinical outcomes seen at 10 weeks of use remained sustained at 26 weeks with statistically significant increases compared to baseline seen in FGA scores (from 15.0 to 19.2), self-selected gait speed (from 0.89 m/s to 0.97 m/s), and 4-Stage Balance Test (from 25.6s to 28.4s), indicating a decrease in fall risk. Non-significant improvements were observed in TUG and fast gait speed. Overall, 39 falls were reported; 31 of them did not require medical treatment and four caused severe injury. Participants who reported falls over 6 months prior to the study had a 43% decrease in fall rate during the study as compared to self-report 6-month pre-study (11.8 vs. 6.7 falls/1000 patient days, respectively, p<0.004), similar to the 46% decrease reported after 10 weeks of use.ConclusionA wearable sensory prosthesis can improve outcomes of gait and balance function and substantially decreases incidence of falls during long-term use. The sustained long-term benefits in clinical outcomes reported here lessen the likelihood that improvements are placebo effects.Trial registrationClinicalTrials.gov (#NCT03538756)
“Somos fieles creyentes”: children’s construction of spiritual and literate identities at home
Authors: Dávila Denise 
Published: April 2022

PurposeSet in a Mexican-American community of a US Gulf Coast state, the purpose of this paper was to describe how three young siblings and their family members constructed their spiritual, ethnic and communicative identities within the context of a virtual family literacy program during COVID-19.Design/methodology/approachThis project was approached as an illustrative case study that focused on one family’s engagement with a children’s book in which the protagonists retell the legend of the Catholic patroness of the Americas, Our Lady of Guadalupe.FindingsThe case study illustrates how the children's spiritual/religious identities were inseparably intertwined with their home literacy practices and their identities as communicators with others. The children’s everyday spiritual/religious practices, routines and activities motivated familial conversations and dialogue that engage and support children’s literacy development.Originality/valueAlthough there is a large corpus of scholarship about secular early literacy program for families with preschool children, there are few that describe the recognition and inclusion of families’ spiritual/religious identities.
Readiness for sustainable-resilience in healthcare organisations during Covid-19 era
Authors: Thomas Albi , Suresh M. 
Published: April 2022

Purpose
Using total interpretive structural modelling (TISM), this paper aims to “identify”, “analyse” and “categorise” the sustainable-resilience readiness factors for healthcare during the Covid-19 pandemic.

Design/methodology/approach
To obtain the data, a closed-ended questionnaire was used in addition to a scheduled interview with each respondent. To identify how the factors interact, the TISM approach was employed and the cross-impact matrix multiplication applied to a classification method was used to rank and categorise the sustainable-resilience readiness factors.

Findings
This study identified ten sustainable-resilience readiness factors for healthcare during the Covid-19 pandemic. The study states that the major factors are environmental scanning, awareness and preparedness, team empowerment and working, transparent communication system, learning culture, ability to respond and monitor, organisational culture, resilience engineering, personal and professional resources and technology capability.

Research limitations/implications
The study focused primarily on sustainable-resilience readiness characteristics for the healthcare sector.

Practical implications
This research will aid key stakeholders and academics in better understanding the factors that contribute to sustainable-resilience in healthcare.

Originality/value
This study proposes the TISM technique for healthcare, which is a novel attempt in the subject of readiness for sustainable-resilience in this sector. The paper proposes a framework including a mixture of factors for sustainability and resilience in the healthcare sector for operations.
BUILD: a five-step process to develop theory-driven social marketing interventions
Authors: Van Hierden Yannick , Dietrich Timo , Rundle-Thiele Sharyn 
Published: April 2022

Purpose
In social marketing practice, there is no all-encompassing approach that guides researchers and practitioners to build theory-driven social marketing interventions. While the Co-create–Build–Engage (CBE) process offers a roadmap for marketing application, including outlining when and where social marketing’s eight benchmark principles have been applied, limited practical guidance on how and when theory should be applied is offered. This paper reports one case study demonstrating how theory was applied to deliver a theory-informed well-being behavior change intervention.

Design/methodology/approach
This paper proposes and applies a new five-step theory-driven social marketing intervention build process (BUILD) drawn from an extensive base of social marketing research and application. Using a case study method, we showcase how the five-step process was applied to inform the design, build and implementation of a well-being behavior change intervention.

Findings
This study proposes a five-step process to build theory-driven social marketing interventions called BUILD: Begin with the objective, Use theory, Initiate program design, Let’s produce and Develop the engagement plan. This study provides a step-by-step and easy-to-follow BUILD process which outlines how social marketers can apply a selected theory to inform program design and implementation.

Practical implications
The BUILD process offers a roadmap to build theory-driven social marketing interventions that include all elements of intervention development, namely, objective-setting, theory evaluation, selection and application, producing the program and planning for program engagement.

Originality/value
This study provides a novel five-step process to help social marketing researchers and practitioners build theory-driven social marketing interventions.
Evaluation of safety-based performance in construction projects with neutrosophic data envelopment analysis
Authors: Li Jianzhong , Alburaikan Alhanouf , de Fátima Muniz Rita 
Published: April 2022

PurposeThe main purpose of this paper is to create a suitable structure based on neutrosophic numbers to evaluate the safety performance in construction projects in such a way that the shortcomings can be highlighted with the reasoned measurement and possible strategies can be recommended.Design/methodology/approachData envelopment analysis (DEA), which is a useful tool for performance appraisal, along with neutrosophic logic, which is one of the most complete tools for handling uncertainty phenomenon, has been used to evaluate the safety performance of construction projects. With this hybrid model, a new strategy is considered as an indicator for safety performance and comparisons are made between different units.FindingsA total of 35 Chinese organizations with construction projects lasting between 1.5 and 2 years were selected for comparison. After processing the data into neutrosophic numbers and using the NN-DEA model, it can be found that projects that pay more attention to safety issues such as training and equipment are more efficient.Originality/valueSince in the real world, there are uncertainties with different contradictions, and neutrosophical data can handle many of these challenges, using DEA model with neutrosophic numbers to evaluate the performance of construction projects from a safety perspective, can provide significantly better results. Therefore, considering that no study has been presented in this field so far, the authors will deal with this topic.
Simplified predictive current controller for three-to-five-phase direct matrix converter
Authors: Roy Taposh Kumar , Habibullah Md 
Published: April 2022

Purpose
Predictive current control (PCC) of three-to-five-phase direct matrix converters (DMCs) is computationally expensive. For this reason, this study aims to consider a reduced number of switching states of DMC in PCC algorithm to predict the control objectives, such as output current control and input reactive power control.

Design/methodology/approach
The switching sequences which yield the voltage vectors of variable amplitude at a constant frequency in space are considered for the prediction and optimization step of PCC algorithm. For the selected voltage vectors, the phase angles of the output vectors are independent on the phase angles of the input vectors. In a three-to-five-phase DMC, there are 243 valid switching states. Among the switching states, only 91 states are considered using the aforementioned concept of variable amplitude output at a constant frequency. This reduced number of switching states simplifies the computational complexity of MPC based current control of three-to-five-phase DMC.

Findings
The computational complexity of the proposed PCC based DMC is lower than the all 243 vectors based PCC. The current total harmonic distortion, transient current response and input reactive power control for the simplified 91 vector based PCC are similar to the all 243 vectors based PCC.

Originality/value
A reduced number of switching sequence is considered for the prediction and optimization step of PCC algorithm. Hence, PCC algorithm can be sampled at a high frequency in real-time applications. Then, the performance of the PCC will be improved.
Quantitative assessment of wheat quality using near‐infrared spectroscopy: A comprehensive review
Authors: Du Zhenjiao , Tian Wenfei , Tilley Michael , Wang Donghai , Zhang Guorong , Li Yonghui 
Published: April 2022

AbstractWheat is one of the most widely cultivated crops throughout the world. A great need exists for wheat quality assessment for breeding, processing, and products production purposes. Near‐infrared spectroscopy (NIRS) is a rapid, low‐cost, simple, and nondestructive assessment method. Many advanced studies associated with NIRS for wheat quality assessment have been published recently, either introducing new chemometrics or attempting new assessment parameters to improve model robustness and accuracy. This review provides a comprehensive overview of NIRS methodology including its principle, spectra pretreatments, spectral wavelength selection, outlier disposal, dataset division, regression methods, and model evaluation. More importantly, the applications of NIRS in the determination of analytical parameters, rheological parameters, and end product quality of wheat are summarized. Although NIRS showed great potential in the quantitative determination of analytical parameters, there are still challenges in model robustness and accuracy in determining rheological parameters and end product quality for wheat products. Future model development needs to incorporate larger databases, integrate different spectroscopic techniques, and introduce cutting‐edge chemometrics methods. In addition, calibration based on external factors should be considered to improve the predicted results of the model. The NIRS application in micronutrients needs to be extended. Last, the idea of combining standard product sensory attributes and spectra for model development deserves further study.
Balloon dilatation complications during esophagogastric anastomotic stricture treatment under fluoroscopy: Risk factors, prevention, and management
Authors: Wang Shuai , Li Xiaobing , Zhang Chenchen , Yin Meipan , Ma Yaozhen , Tong Yalin , Wang Meng , Liu Chao , Zhu Ming , Wu Gang 
Published: April 2022

AbstractBackgroundBalloon dilatation (BD) is a common treatment for esophagogastric anastomotic stricture (EAS), but with complications. This study investigates the risk factors, prevention, and management of BD complications to provide clinical guidance.MethodsWe retrospectively analyzed the clinical data of 378 patients with EAS treated by BD from March 2011 to June 2021. The association between esophagogastric anastomotic rupture outcome and patient and stricture characteristics and treatment were analyzed by logistic regression.ResultsBD was performed 552 times and technical success, 98.0%; overall clinical success, 97.8%; major adverse events, 1.3%; minor adverse events, 9.4%; mortality, 0.3%. Logistic regression showed that age (p = 0.080), sex (p = 0.256), interval from surgery to stricture development (p = 0.817), number of dilatations (p = 0.054), cause of stricture (p ≥ 0.168), and preoperative chemotherapy (p = 0.679) were not associated with anastomotic rupture. Balloon diameter (p < 0.001), preoperative radiotherapy (p = 0.003), and chemoradiotherapy (p = 0.021) were correlated with anastomotic rupture. All patients with type I and II ruptures resumed oral feeding without developing into type III rupture. Type III rupture occurred in six cases, who resumed oral feeding after 7–21 days of nasal feeding and liquid feeding. One patient died of massive bleeding after BD.ConclusionsSymptomatic treatment for type I and II ruptures and transnasal decompression and jejunal nutrition tubes for type III rupture, are suggested pending rupture healing. Tumor recurrence, preoperative radiotherapy, and balloon diameter affected the anastomotic rupture outcome.
Hematospermia is rarely associated with urologic malignancy: Analysis of United States claims data
Authors: Hakam Nizar , Lui Jason , Shaw Nathan M. , Nabavizadeh Behnam , Smith James F. , Eisenberg Michael L. , Breyer Benjamin N. 
Published: April 2022

AbstractBackgroundHematospermia is an alarming symptom and can cause significant patient distress, but work‐up is often negative.ObjectiveTo characterize the clinical evaluation of hematospermia and its association with the diagnosis of urologic malignancy.Materials and methodsUsing MarketScan insurance claims database, we identified adult males 18–64 years old diagnosed with hematospermia from 2010 to 2018. Benign hematospermia was defined as the absence of hematuria and elevated prostate‐specific antigen. Patients with urologic cancer prior to diagnosis of hematospermia were excluded. We identified those who were diagnosed with a urologic malignancy.ResultsThe annual average incidence rate of hematospermia was 56.6 per 100,000 (95% confidence interval 55.4–57.8 per 100,000) in 2010 and increased to 73.6 per 100,000 (95% confidence interval 71.7–75.4 per 100,000) in 2018. A total of 56,157 patients presented with benign hematospermia. Most (57.5%) underwent at least one test, with the most common being urinalysis (51.7%), followed by prostate‐specific antigen testing (11.9%). All other tests were performed in less than 3% of patients. Forty‐seven patients were diagnosed with a urologic cancer, including 28 with prostate cancer (0.05%), nine with testicular cancer (0.016%), six with prostate carcinoma in situ (0.01%), and four with bladder cancer (0.007%). Stratified by age, there was only one cancer diagnosis (testicular) in 15,106 patients under 40 years (0.01%) and 46 cancer diagnoses in 40,611 patients 40 years old or above (0.11%). The median age of patients diagnosed with cancer was 56 years (interquartile range 52–61).Discussion and conclusionA small minority of patients with benign hematospermia were later diagnosed with urologic cancer in a large nationally representative sample. After excluding hematuria with urinalysis, physicians should conservatively manage and reassure patients with hematospermia, especially those under 40 years of age.
Evaluating the diagnostic role of in‐bore magnetic resonance imaging guided prostate biopsy: a single‐centre study
Authors: Furrer Marc A. , Hong Anne , Wetherell David , Heinze Stefan B. , Simkin Paul , Chow Ken , Lawrentschuk Nathan , Zargar Homayoun 
Published: April 2022

AbstractBackgroundTo evaluate the role of in‐bore MRI‐guided biopsy (IB‐MRGB) in the diagnosis of clinically significant prostate cancer (csPCa).MethodsIn this tertiary single centre study, a total of 125 consecutive patients receiving IB‐MRGB over a three‐year period were evaluated, including 73 patients who had prior biopsies and 52 biopsy‐naïve patients. We assessed cancer detection rate of patients according to the degree of suspicion based on mpMRI findings. Histopathological data were reviewed by experienced uropathologists.ResultsThe mpMRI was suspicious for PCa (PI‐RADS 4/5) in 77% (96/125) and equivocal (PI‐RADS 3) in 23% (29/125). The detection rate for csPCa was 54.2% (52/96) and 20.7% (6/29) for suspicious lesions (PI‐RADS 4/5) and equivocal lesions (PI‐RADS 3), respectively. In subgroup analysis, patients with previous negative biopsy, overall positive biopsy rate and csPCa detection rate were 48.3% (19/35) and 34.5% (13/35), respectively. In patients on AS, 36/44 (81.8%) and 21/44 (47.8%) had PCa and csPCa respectively. In biopsy‐naïve patients 34/52 (65.4%) and 27/52 (51.92%) had PCa and csPCa respectively. Of the patients on AS, 18/44 (41.6%) upgraded from ISUP 1 to ISUP 2 PCa, and 4/44 (9.1%) upgraded from ISUP 1 to ISUP 3 PCa on IB‐MRGB. A total of 14 Clavien‐Dindo≤2 complications occurred in 14 patients (11.2%) that were directly related to the biopsy. No Clavien‐Dindo≥3 complications occurred.ConclusionMRI‐targeted biopsy is suitable for assessment of csPCa. Given the favourable complications profile, its use may be considered in both the initial biopsy and re‐biopsy settings.
Informal Waste Recycling Economies in the Global South and the Chimera of Green Capitalism
Authors: Fevrier Kesha 
Published: April 2022

AbstractThis paper contends that green growth/economy strategies directed at the global South through ideas such as the circular economy (CE) can maintain and reproduce predatory practices that aggressively exploit racialised groups, while simultaneously cannibalising their environments. These green strategies facilitate transfers of wealth from the global South to the North through new socio‐spatial frontiers for wealth creation, global South cities, and their expanding, dispossessed, unhoused, and racialised army of informal labour. Green growth/economy strategies—mechanisms that attempt to “green” capitalism—are portrayed as a chimera that can reproduce racial forms of exploitation and accumulation in discursive and material ways. Green campaigns that attempt to reconstruct notions of waste and value, and re‐imagine informal waste work as good and safe, neglect an accounting of race and the historical, political, and economic factors that make possible waste recycling as a viable economic strategy for sustainable development in the global South.