bluuebunny/crossref_metadata_2025_split huggingface dataset:
Do inhaled or oral glucocorticoids more effectively control feline asthma?
Authors: Williams Savannah 
Published: December 2022

PICO question
In cats with chronic bronchospasm and airway hypersensitivity (asthma) do oral glucocorticoids or inhaled glucocorticoids more effectively control the clinical signs?

Clinical bottom line
Category of research question
Treatment
The number and type of study designs reviewed
Three prospective randomised clinical trials were appraised. Two of the studies followed a crossover design and had a control group, whilst the third study described an interrupted time series
Strength of evidence
Weak
Outcomes reported
The available studies deemed a reduction in eosinophilia on bronchoalveolar lavage fluid analysis, and a reduction in airway resistance as markers of treatment efficacy
Conclusion
There is weak evidence to suggest equal treatment efficacy of oral and inhaled glucocorticoid therapy for management of feline asthma. Higher powered studies would be required before a definitive recommendation can be made

How to apply this evidence in practice
The application of evidence into practice should take into account multiple factors, not limited to: individual clinical expertise, patient’s circumstances and owners’ values, country, location or clinic where you work, the individual case in front of you, the availability of therapies and resources.
Knowledge Summaries are a resource to help reinforce or inform decision making. They do not override the responsibility or judgement of the practitioner to do what is best for the animal in their care.
POTENSI EKSTRAK ETIL ASETAT Coprinus comatus TERHADAP KADAR UREUM DAN KREATININ PADA TIKUS PUTIH MODEL DIABETES
Authors: Perdanawati Anik Laeli , Ratnaningtyas Nuniek Ina , Hernayanti Hernayanti 
Published: December 2022

Coprinus comatus atau jamur paha ayam berpotensi sebagai antioksidan dan antidiabetes. Kondisi hiperglikemia pada penderita diabetes mellitus menyebabkan peningkatan Reactive Oxygen Species (ROS). Sel β pankreas memiliki antioksidan hanya sedikit dibandingkan organ lain. Hal ini menyebabkan stress oksidatif yang memicu reaksi berantai peroksidasi lipid sehingga merusak organ ginjal dan laju filtrasi glomerulus terganggu. Laju filtrasi glomerulus yang terganggu ditandai dengan peningkatan kadar ureum dan kreatinin. Flavonoid yang terkandung dalam C. comatus mampu mendonorkan H+ dan menghentikan reaksi peroksidasi lipid pada ginjal sehingga kadar ureum dan kreatinin menurun.Penelitian ini bertujuan untuk mengetahui pengaruh ekstrak etil asetat C. comatus terhadap kadar ureum dan kreatinin darah tikus model diabetes dan untuk mengetahui dosis efektif ekstrak etil asetat C. comatus terhadap kadar ureum dan kreatinin darah tikus model diabetes.
Penelitian ini menggunakan metode eksperimental yang disusun berdasarkan Rancangan Acak Lengkap (RAL). Data yang diperoleh dari hasil pengukuran kadar ureum dan kreatinin dianalisis menggunakan uji statistik one way Anova pada tingkat kepercayaan 95% dan dilanjutkan dengan uji Duncan pada tingkat kesalahan 5%. Hasil penelitian ini menunjukkan bahwa ekstrak etil asetat C. comatus berpengaruh terhadap kadar ureum dan kreatinin darah tikus model diabetes. Ekstrak C. comatus dosis 500 mg/kgBB merupakan dosis efektif yang berpengaruh terhadap penurunan kadar ureum dan kreatinin darah pada tikus model diabetes yaitu sebesar 16,66 ± 0,00 mg/dL dan 0,40 ± 0,12 mg/dL.
Authors: Rahmawati Alfiani , . Oedjijono , Ryandini Dini 
Published: December 2022

Penelitian ini bertujuan untuk mengetahui kemampuan isolat bakteri sedimen mangrove dalam menghasilkan enzim amilase, mengetahui pH dan suhu optimum aktivitas amilase yang dihasilkan, dan mengidentifikasibakteri penghasil amilase. Penelitian dilakukan dengan metode survei. Tahap penelitian meliputi, skrining bakteri amilolitik, pembuatan kurva tumbuh, produksi amilase, optimasi aktivitas amilolitik pada variasi suhu (35ºC; 36ºC; 37ºC; 38ºC) dan pH (4,5; 5; 5,5; 6) serta karakterisasi isolat amilolitik. Parameter yang diukur yaitu indeks amilolitik, unit aktivitas enzim amilase, total unit bakteri, dan identitas bakteri amilolitik asal sedimen mangrove. Analisis data dilakukan secara deskriptif. Hasil pengukuran indeks amilolitik tertinggi ditunjukkan oleh isolat LG113 dengan nilai indeks amilolitik 9,86 mm dari 10 isolat amilolitik asal sedimen mangrove. Suhu optimum aktivitas amilase adalah 37ºC yaitu sebesar 2,13 U/mL dan pH optimum adalah 6 yaitu sebesar 2,14 U/mL. Jumlah total sel bakteri amilolitik padaakhir masa produksi adalah 1,94x1013 CFU/mL. Identitas isolat bakteri amilolitik asal sedimen mangrove pantai Logending termasuk anggota genus Bacillus.
Authors: Apriyani Tri Rahayu , Ekowati Nuraeni , Ratnaningtyas Nuniek Ina 
Published: December 2022

Penelitian ini bertujuan untuk mengetahui pengaruh interaksi antara konsentrasi glukosa dan waktu inkubasi terhadap pertumbuhan jamur S. commune dan bobot β-glukan juga untuk mengetahui konsentrasi glukosa dan waktu inkubasi yang terbaik untuk pertumbuhan jamur S. commune dan produksi β-glukan. Penelitian dilakukan dengan metode eksperimental rancangan acak lengkap pola faktorial (RAL Faktorial) dengan dua faktor yang dilakukan dalam tiga kali pengulangan. Perlakuan yang diberikan meliputi variasi konsentrasi glukosa (G) dengan tiga taraf yaitu 10 g/L (G1), 20 g/L (G2), dan 30 g/L (G3), dan variasi waktu inkubasi (W) dengan tiga taraf yaitu waktu inkubasi 20 hari (I1), waktu inkubasi 25 hari (I2), dan waktu inkubasi 30 hari (I3). Variabel yang digunakan dalam penelitian ini adalah variabel bebas dan terikat. Variabel bebas yaitu konsentrasi glukosa dan waktu inkubasi, sedangkan variabel terikat yaitu pertumbuhan miselium jamur dan produksi β-glukan. Parameter utama yang diamati adalah bobot β-glukan. Parameter pendukungnya adalah bobot biomasa kering dan pH akhir medium. Analisis data dilakukan dengan Analysis of Variance (ANOVA) pada tingkat ketelitian 95%, dilanjutkan dengan uji Duncan (Ducan Multiple Range Test). Hasil yang diperoleh menunjukkan bahwa konsentrasi glukosa dan waktu inkubasi berpengaruh terhadap pertumbuhan dan produksi β-glukan jamur S. commune. Konsentrasi glukosa 30 g/L dan waktu inkubasi 25 hari merupakan konsentrasi glukosa dan waktu inkubasi yang optimum terhadap pertumbuhan jamur S. commune, serta konsentrasi glukosa 30 g/L dan waktu inkubasi 25 hari merupakan konsentrasi glukosa dan waktu inkubasi yang optimum terhadap produksi β- glukan jamur S. commune.
Authors: Yuspiah Eka Fitriani , Rahayu Yeni , Miftahuddin Miftahuddin 
Published: December 2022

Abstrak Bayam (Amaranthus tricolor) adalah sayuran popular di Indonesia sebagai sumber vitamin dan mineral. Namun, tanaman ini rentan terkontaminasi logam berat, salah satunya timbal. Penelitian ini bertujuan untuk menganalisis respons pertumbuhan dan fisiologi A. tricolor yang dipapar timbal (Pb(NO3)2 menggunakan sistem hidroponik sumbu. Penelitian dilakukan menggunakan rancangan acak lengkap satu faktor dengan empat perlakuan konsentrasi timbal, yaitu 0 ppm, 1 ppm, 3 ppm, dan 5 ppm, diulangi 2 kali. Data dianalisis menggunakan ANOVA satu arah, dan uji lanjut dengan Duncan pada taraf kepercayaan 5%. Respons pertumbuhan yang diamati yaitu tinggi tanaman, jumlah daun, warna daun, berat segar tajuk dan akar, serta berat kering tajuk dan akar. Respons fisiologi yang diamati yaitu kadar klorofil tanaman. Hasil penelitian diperoleh bahwa tanaman bayam yang dipapar (Pb(NO3)2 mengalami penurunan tumbuh yang signifikan, pada parameter tinggi tanaman, jumlah daun, berat segar tajuk dan akar, berat kering tajuk dan akar, serta kadar klorofil. Perlakuan timbal tersebut juga menyebabkan kerontokan akar, perubahan warna daun menjadi kekuningan, serta terdapat bintik kuning dekat pertulangan daun. Analisis serapan logam timbal pada batang dan daun bayam menunjukkan nilai serapan meningkat seiring penambahan konsentrasi timbal pada perlakuan. Perlakuan (Pb(NO3)2 dengan konsentrasi 5 ppm menunjukkan hasil yang terendah pada seluruh parameter pengamatan.
Kata kunci : Amaranthus tricolor, Cemaran Logam, Sistem Hidroponik Sumbu, Timbal.
Authors: Sir Makdalena Viviliani , Herawati Wiwik , Sukarsa Sukarsa 
Published: December 2022

Pewarna alami merupakan senyawa yang dapat dihasilkan dari berbagai jenis sumber alam.Tumbuhan penghasil pewarna alami dapat diperoleh dari bagian-bagiannya seperti daun, kulit batang, kulit buah, biji, akar dan bunga, yang telah melalui beberapa proses yaitu direbus, dibakar, dimemarkan ditumbuk dan langsung digunakan. Penelitian ini bertujuan untuk mengetahui jenis-jenis tumbuhan yang dimanfaatkan sebagai pewarna alami batik, dan mengetahui bagian organ tumbuhan yang dimanfatkan sebagai pewarna alami batik. Metode yang digunakan dalam penelitian ini adalah metode survei. Pengambilan sampel dilakukan secara purposive sampling. Pengambilan data dilakukan dengan pengamatan dan wawancara langsung ke home industry batik Kabupaten Banyumas. Parameter yang digunakan adalah jenis tumbuhan dan organ tumbuhan yang digunakan sebagai pewarna alami batik. Data ditabulasikan dan diidentifikasi untuk dianalisis. Analisis data hasil penelitian dilakukan secara deskriptif.
Tumbuhan yang dimanfaatkan sebagai pewarna alami batik dibeberapa Home Industry Batik di Kabupaten Banyumas Terdiri Dari 12 spesies tumbuhan. bagian tumbuhan yang digunakan adalah akar, batang, daun, kayu, kulit kayu, kulit buah, rimpang, bunga ranting dan sabut. pewarna alami batik didapatkan dengan cara direbus dan ditumbuk. kemudian digunakan dengan cara direndam, dicelupkan, dan untuk mengambar motif.
Authors: Maharani Amalia Sofia , Ekowati Nuraeni , Ratnaningtyas Nuniek Ina 
Published: December 2022

Penelitian ini bertujuan untuk mengetahui pengaruh pH dan waktu inkubasi yang berbeda terhadap pertumbuhan dan produksi β-glukan jamur S. commune, dan mengetahui nilai pH dan waktu inkubasi yang optimum terhadap pertumbuhan dan produksi β-glukan jamur S. commune. Penelitian dilakukan dengan metode eksperimental rancangan acak lengkap pola faktorial (RAL Faktorial) dengan dua faktor yang dilakukan dalam tiga kali pengulangan. Perlakuan yang diberikan meliputi variasi pH (P) dengan tiga taraf yaitu pH 5 (P1), pH 6 (P2), dan pH 7 (P3), dan variasi waktu inkubasi (W) dengan tiga taraf yaitu waktu inkubasi 20 hari (W1), waktu inkubasi 25 hari (W2), dan waktu inkubasi 30 hari (W3). Variabel yang digunakan dalam penelitian ini adalah variabel bebas dan terikat. Variabel bebas yaitu pH dan waktu inkubasi, sedangkan variabel terikat yaitu pertumbuhan miselium jamur dan produksi β-glukan. Parameter utama yang diamati adalah bobot β-glukan. Parameter pendukungnya adalah bobot biomasa kering dan pH akhir medium. Analisis data dilakukan dengan alysis of Variance (ANOVA) pada tingkat ketelitian 95%, dilanjutkan dengan uji Duncan (Ducan Multiple Range Test). Hasil yang diperoleh menunjukkan bahwa pH dan waktu inkubasi berpengaruh terhadap pertumbuhan dan produksi β-glukan jamur S. commune. Nilai pH 6 dan waktu inkubasi 25 hari merupakan pH dan waktu inkubasi yang optimum terhadap pertumbuhan jamur S. commune, serta pH 5 dan waktu inkubasi 25 hari merupakan pH dan waktu inkubasi yang optimum terhadap produksi β-glukan jamur S. commune.
The Application of Chitosan as a Natural Flocculant Material to Chlorella sp. Abundance
Authors: Puspaningsih Dewi , Setiadi Eri , Setijaningsih Lies , Taufik Imam 
Published: December 2022

Natural feed must be available in order to give high-quality seeds to support aquaculture activities. Chlorella sp. is a natural food source for fish larvae and zooplankton.Â Chlorella sp. is more effective and efficient when stored in the form of floc. The purpose ofÂ this research was to obtain an effective dose of chitosan for flocculation of Chlorella sp. The study used a completely randomized design (CRD) with 5 treatments and 3 replications, i.e A. 150 mg L-1, B. 200 mg L-1, C. 250 mg L-1, D. 300 mg L-1, E. 350 mg L-1. The abundance of Chlorella sp. before and after flocculation measured as the main parameter. Water quality parameter such as temperature, pH, dissolved oxygen, total ammonia nitrogen, and nitrite function as supporting parameters. The results showed that the abundance of Chlorella sp. before flocculation increased from the beginning of stocking until the 6th day. The best results of the abundance of Chlorella sp. found in the C treatment (54.4-74.5%), then followed with B, A, D, and E treatments (31.2-55.1%, 22.8-51.2%, 19.0-45.6 %, and 13.3-44.6%) respectively. The most effective dose of chitosan in the flocculation process of fresh water Chlorella sp. was 250 mg L-1 with an abundance of 39.1x105 cells mL-1. Water quality in culture media of the Chlorella sp. showed that the range of measured values were still within the optimum range.Keywords: Abundance, Chitosan, Chorella sp., Flocculation
Concentration of Ammonia Pollution in Madura Traditional Salt Production Water
Authors: Asih Eka Nurrahema Ning , Kartika Ary Giri Dwi , Efendy Makhfud , Dewi Kartika , Fadloli Bahri , Zain Arya Galin Fakhrul Islami 
Published: December 2022

Ammonia (NH3) is one of the impurities in salt-producing water, which is often found in the traditional salt ponds of the Madurese. The purpose of this study was to determine the concentration of ammonia contamination as an impurity in salt production process water from raw water, reservoir ponds, evaporator ponds to geomembrane crystallizer ponds when salt production takes place in the salt ponds of Tanjungan Village, Bangkalan Regency. Determination of ammonia concentration using the phenate method based on SNI 06-6989.30-2005 with a spectrophotometer reading tool (UV-2700 Serial No. A11674900027) at a wavelength of 420 nm. The average concentration of ammonia as an impurity in raw materials in traditional pond ponds in Tajungan village, namely raw water is 2.31Â±0.24 mg/L, reservoir ponds are 2.56Â±0.57 mg/L, evaporator ponds are 2, 39Â±0.84 mg/L and the geomembrane crystallizer ponds are 1.37Â±0.09 mg/L. The highest average ammonia concentration was found in the reservoir ponds raw saltwater sample, while the lowest concentration was found in the geomembrane crystallizer ponds sample. The high average ammonia concentration in the salt ponds of Tajungan Village, Bangkalan Regency indicates that all raw saltwater in these ponds is contaminated with ammonia. The high concentration of ammonia in the salt ponds may be due to the entry of household waste.Â Keywords: (NH3), raw water, reservoir ponds, evaporation ponds, geomembrane crystallizer ponds
Growth Characteristics and Condition Factors Of Red Snapper (Lutjanus campechanus) Landed at PPI Cikidang Pangandaran West Java
Authors: Nurlita Vika , Sanjayasari Dyahruri 
Published: December 2022

Pangandaran waters is one of productive fishing ground for Indonesian fisheries. One of potential catch in this area is red snapper. Red snapper (Lutjanus campechanus) is a type of demersal fish. This species can live in shallow waters to deep seas. Growth measurement is carried out as an anticipation on the presence of overfishing which causes red snapper stocks to decline. Hence, current field work focused on the growth characteristics and factor conditions of red snapper which landed in PPI Cikidang Pangandaran west Java. Present study may provide information related on fish species production. The survey and observation methods were used to collect the data in February 2021. The sampling location was carried out at the PPI Cikidang, Pangandaran. The data of weight and length of red snapper landed at PPI Cikidang were recorded and analyzed descriptively. The results revealed that growth of red snapper landed at the PPI Cikidang was categorized as negative allometric with b < 3, at 1.92. The condition factor has an average of 1.29 which means that the fish are classified as fat or not flat.Â Keywords: Growth Characteristics; Condition Factor; Red Snapper; Lutjanus campechanus; PPI Cikidang.
Understanding the Linkages Between Spatio-temporal Urban Land System Changes and Land Surface Temperature in Srinagar City, India, Using Image Archives from Google Earth Engine
Authors: Murtaza Khalid Omar , Shafai Shahid , Peer Shahid , Romshoo Shakil A 
Published: December 2022

Abstract

Land-use and land-cover (LULC) is a necessary component of sustainable natural resource management. There are considerable negative effects on the environment, ecosystem services, and natural resources as a result of the rapid anthropogenic land system changes. One of the significant negative implications of the rapidly changing urban LULC is the increase in the Land Surface Temperature (LST) resulting in the urban heat island effect. In this study, we used a time series of Landsat satellite images from 1992 to 2020 in the Srinagar city of the Kashmir valley, North-western Himalayas India to understand the linkages between LULC dynamics and Land Surface Temperature (LST), derived from the archived images using the Google Earth Engine (GEE). Furthermore, the relation between LST and biophysical indices, i.e., Normalized Difference Vegetation Index (NDVI), and Normalized Difference Water Index (NDWI) was also analysed. LULC change detection analysis revealed that the built-up area has increased significantly, while the vegetation cover and water bodies extent has decreased during the study period. The results showed that the built-up in the city has increased significantly from 12% in 1992 to 40% in 2020, the corresponding plantation has decreased from 26–17% in 2020, Forests have decreased from 4–2% and waterbody extent has declined from 6–4%2 in 28 years. Urban development of Srinagar city has resulted in the depletion of natural land covers, modification of natural drainage, and loss of green and blue spaces over the past few decades. The study revealed that the maximum LST in the city has increased by 11°C from 1992 to 2020. During the same period of time, the minimum LST in the city has increased by 4°C, indicating the impact of urbanization on the city environment. It was found that the normalized difference vegetation index (NDVI) and normalized difference water index (NDWI), two important urban environmental indices are negatively correlated with LST. The findings shall serve as a vital source of knowledge for urban planners and decision-makers to better develop sustainable urban environmental management strategies for Srinagar city.
Minimum Dominating Sets in Uncertain Graphs
Authors: Li Hao , Zang Wenxia 
Published: December 2022

Abstract
Power networks, biological networks, and other networks are becoming more and more complex. And corresponding problems of these networks accompany by uncertainty, which can only rely on expert opinion. In practical applications, the dominating ability of these networks is often within the scope of the designer's consideration. It is more appropriate to use uncertain graphs to characterize these networks. And then it is necessary to explore the domination problem in uncertain graphs. As an important parameter, the minimum dominating set of graphs could be used to measure the dominating ability of some complex networks. In the paper, our discussion will focus on the minimum dominating set problem in uncertain graphs. We will first study the domination number of uncertain graphs and show the formulas for calculating the corresponding distribution and its numerical characteristics. Then two models are proposed to find the minimum dominating set in uncertain graphs. Besides, corresponding algorithms for and some examples are also shown.
Comparison between retroperitoneal laparoscopic nephrectomy and traditional open nephrectomy to treat polycystic kidney disease before kidney translantation
Authors: Lyu Jing-Cheng , Zhu Yichen 
Published: December 2022

Abstract
Objective: To compare the efficiency and safety between retroperitoneal laparoscopic nephrectomy and traditional open nephrectomy to treat autosomal-dominant polycystic kidney disease before kidney transplantation.
Materials and Methods: A total of 57 patients diagnosed with huge autosomal-dominant polycystic kidney disease between 2000 and 2020 at our center were included in this study.Patients were divided into a retroperitoneal laparoscopic (RL; n=23) group and traditional open (TO; n=34) group. We retrospectively analyzed and compared preoperative and perioperative variables between the two groups.
Result: Patients in the RL group showed a longer operation time (201.09±83.76min) compared to patients in the TO group (113.38±51.84min, p＜0.001). The RL group also showed significantly less intraoperative blood loss (p=0.025) and less intraoperative blood transfusion volume (p=0.016) compared to the TO group. Meanwhile, time of gastrointestinal function recovery, bed leave, catheter indwelling and postoperative hospitalization in the RL group were 2.13±0.63, 1.30±1.0, 5.22±2.09, 7.35±2.48 days, respectively, which were significantly shorter than the TO group (p＜0.05). Pain degree of patients during the first 48 hours after operation was similar between the RL and TO groups, but Opioid use percentage in the RL group was 8.70% (2/23) and was lower than the 26.47% (9/34) in the TO group (p=0.022). Meanwhile, 5 and 23 patients exhibited postoperative complications in the RL and TO groups, respectively (p＜0.001).
Conclusion: Both retroperitoneal laparoscopic nephrectomy and traditional open surgery are feasible to treat huge polycystic nephrectomy. However, patients who undergo retroperitoneal laparoscopic nephrectomy experience higher levels of safety and recover more rapidly.
TRIP13 as a prognostic marker and its correlation with clinicopathological features in human cancers: a meta-analysis
Authors: Li Jipin , Deng Hongyang , Xiao Qi , Zheng Yijun , Wang Mancai , Wang Xiang , Zhang Youcheng 
Published: December 2022

Abstract
Background: Recent studies have shown thyroid hormone receptor interacting protein 13 (TRIP13) is involved in tumorigenesis and associated with poor clinical outcomes. Here, we conducted a meta-analysis to assess the effect of TRIP13 expression on clinicopathological features and prognosis in patients with different kinds of cancers.
Methods: The comprehensive literature search was performed through the PubMed, Embase, and Web of Science electronic databases to identify eligible studies. The pooled hazard ratio (HR) and odds ratio (OR) with 95% confidence interval (CI) were calculated by STATA 15.0 software to evaluate the correlation between TRIP13 with overall survival (OS) and clinicopathology.
Results: In total, 1461 patients from 12 studies were included in this meta-analysis. The pooled results suggested that high expression of TRIP13 correlated to unfavorable OS (HR=1.91, 95%CI 1.67-2.16, P<0.001) with no heterogeneity (I2=0.0, P=0.975). Subgroup analysis also indicated a significant association between high TRIP13 expression and poor OS regardless of tumor type, sample size, or method of data extraction. Moreover, a high level of TRIP13 was positively associated with tumor invasion depth (OR=2.86, 95%CI 1.38-5.94), lymph node metastasis (OR=3.72, 95%CI 2.65-5.20), distant metastasis (OR=2.64, 95%CI 1.42-4.91), and advanced TNM stage (OR=2.57, 95%CI 1.87-3.53) in patients with cancers.
Conclusion: High expression of TRIP13 has a significant correlation with poor clinical outcomes and could serve as an unfavorable prognostic biomarker in cancer patients.