bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prevalence and factors associated with sleep disturbance in adult patients with psoriasis
Authors: Sahin E. , Hawro M. , Weller K. , Sabat R. , Philipp S. , Kokolakis G. , Christou D. , Metz M. , Maurer M. , Hawro T. 
Published: January 2022

AbstractBackgroundSleep, which is crucial for restoring of physiological functions and health, is reportedly impaired in psoriasis. The role of different potential sleep confounding factors, including detailed pruritus characteristics, and the complex interplay between psychological variables (anxiety and depression), pruritus and sleep disturbance in psoriasis remain insufficiently investigated.ObjectivesTo investigate sleep characteristics and to identify clinical, demographic and psychological factors associated with sleep disturbance in psoriasis.MethodsThis cross‐sectional study included 334 psoriasis patients (response rate 86%) and 126 control subjects (response rate 82%). Measures included sleep quality [Pittsburgh Sleep Quality Index (PSQI)], psoriasis severity, pruritus characteristics, including average pruritus intensity [visual analogue scale (VAS)], severity of comorbidities, anxiety and depression (Hospital Anxiety and Depression Scale – HADS) and quality of life (Dermatology Life Quality Index – DLQI, and Short Form 12 – SF12).ResultsFifty‐nine per cent of patients and 34% of control subjects (P < 0.001) suffered from sleep disturbance (PSQI > 5). Patients slept 1 h less than control subjects (median 6 vs. 7 h, P < 0.001). Patients without pruritus had less impaired sleep (global PSQI) than patients with strong (P < 0.001) and very strong pruritus (P < 0.001). Anxiety (HADS‐A) and depression (HADS‐D) levels were the strongest predictors of sleep impairment, followed by pruritus exacerbation at night, age, female sex, pruritus exacerbation in the morning, average pruritus intensity (VAS), diagnosed depression and gastroesophageal reflux disease, altogether explaining 32%–37% of the variance in global sleep quality. Both anxiety (HADS‐A) and depression (HADS‐D) were significant mediators explaining the association between pruritus intensity (VAS) and sleep impairment in 42% and 37% respectively.ConclusionsSleep disturbance in patients with psoriasis is highly prevalent. Patients with psoriasis should be assessed for sleep impairment, pruritus, anxiety and depression. Reduction in pruritus should be considered as an important therapeutic goal, along with therapies aimed at reducing anxiety and depression.
Adolescent pornography consumption: A symbolic interactionist lens
Authors: Farina Rachael E. 
Published: January 2022

AbstractPornography consumption is commonplace amongst adolescents In the United States and other countries. Curiosity exists about the role consumption (both type and frequency) potentially plays in cognitive, psychological, and behavioral outcomes for this population. Theories such as symbolic interactionism assist in our understanding of how meaning relates to these outcomes. The current article includes existing literature and established constructs derived from symbolic interactionist theory along with gender as a moderator. Collectively, this information serves as a basis for the proposed midrange model exploring adolescent pornography consumption and varying associated positive and negative outcomes.
Parents' reflective functioning and their agreement on treatment goals in attachment‐based family therapy for sexual and gender minority young adults and their nonaccepting parents
Authors: Strifler Yotam , Zisenwine Tamar , Diamond Gary M. 
Published: January 2022

AbstractThis study examined the trajectories of parents' reflective functioning over the course of individual preparatory sessions with the therapist in attachment‐based family therapy (ABFT) for Israeli sexual minority young adults and their nonaccepting parents, and whether such reflective functioning was associated with parents' agreement on the goals for subsequent conjoint corrective attachment sessions. Three parents with good agreement on treatment goals were compared to three parents with poor agreement on treatment goals. Parents' in‐session reflectivity regarding their child's experience of nonacceptance, and regarding the quality of their relationship with their child, was observationally measured at the session level. Reflective functioning increased over time among those parents who reported good agreement with the treatment goals. There were no changes in parents' reflective functioning in the poor agreement group. Findings suggest the potential importance of facilitating parents' reflective functioning in ABFT, before conducting conjoint corrective attachment sessions. Research and clinical implications are discussed.
LncRNA HCG11 represses ovarian cancer cell growth via AKT signaling pathway
Authors: Chen Xiaoping , Yang Yusheng , Sun Jie , Hu Chaofeng , Ge Xiaohong , Li Rong 
Published: January 2022

AbstractAimOvarian cancer is a main contributor of cancer‐relevant deaths among women worldwide due to high incidence and mortality. Mounting evidence has unveiled that lncRNAs play critical roles in malignancies, including ovarian cancer. Although the tumor suppressor function of HCG11 in prostate cancer and glioma has been proved, investigations on HCG11 role in ovarian cancer are still scarce.MethodsGene or protein expression was quantified by RT‐qPCR or western blot. HCG11 effects on ovarian cancer were assessed by functional assays. Bioinformatics analysis and mechanism experiments were implemented to identify the association among HCG11, miR‐1270, and PTEN.ResultsHCG11 was weakly expressed in ovarian cancer and functioned as a tumor suppressor in ovarian cancer by retarding cell proliferation, migration, and EMT. Besides, HCG11 could bind to miR‐1270 and PTEN was a target gene of miR‐1270. Mechanically, HCG11 competitively bound with miR‐1270 to upregulate PTEN. From rescue experiments, HCG11 impeded AKT/mTOR pathway to retard ovarian cancer cell growth by miR‐1270/PTEN.ConclusionsHCG11 was a tumor suppressor in ovarian cancer cells and additionally, HCG11 regulated AKT/mTOR pathway to hinder ovarian cancer cell growth via modulating miR‐1270/PTEN, indicating that HCG11 may represent a promising target for effective treatment of ovarian cancer patients.
The mouth‐opening muscular performance in adults with and without temporomandibular disorders: A systematic review
Authors: Greenbaum Tzvika , Pitance Laurent , Kedem Ron , Emodi‐Perlman Alona 
Published: January 2022

AbstractBackgroundThe mouth‐opening muscular performance in patients with temporomandibular disorders (TMDs) is unclear. Understanding the impairments of this muscle group within specific TMDs is important to develop proper management strategies.ObjectiveTo characterise the mouth‐opening muscular performance in adults with and without TMDs.MethodsPubMed, EMBASE, CINAHL, Scopus, Web of Science and Cochrane databases were searched from inception to 12 November 2020. Bibliographies were searched for additional articles, including grey literature. Case‐control, cross‐sectional and interventional studies reporting mouth‐opening muscular strength and/or endurance were included. Risk of bias was assessed by the SIGN checklist for case‐control studies and by the NIH quality assessment tool for cross‐sectional studies. Results were pooled with a random‐effects model. Confidence in cumulative evidence was determined by means of the GRADE guidelines.ResultsFourteen studies were included; most were rated as having a moderate risk of bias. Only three studies assessed patients with TMDs and the other 11 assessed healthy adults. Significant sex differences in muscular performance were found for healthy adults in the review (strength deficit for females versus males). There was a significant reduction in maximal mouth opening performance (strength and endurance) in the three studies that assessed patients with temporomandibular disorders.ConclusionSex plays a significant role in maximal mouth opening strength. There is a lack of reliable data on the normal mouth‐opening strength and endurance of healthy adults as well as for patients with TMDs.ImplicationsLack of reliable TMDs patient data and comparable healthy adult data highlight future direction for research.
Accuracy of 3D Printed and Digital Casts Produced from Intraoral and Extraoral Scanners with Different Scanning Technologies: In Vitro Study
Authors: Ellakany Passent , Aly Nourhan M. , Al‐Harbi Fahad 
Published: January 2022

AbstractPurposeTo compare the accuracy of 3D printed and digital casts produced from various intraoral and extraoral scanners with different scanning technologies.Materials and MethodsA conventional stone cast was fabricated from the reference typodont cast and scanned with two intraoral scanners (TRIOS 3 version 1.4.7.5, and Dental Wings version 2.1.0.421), and two extraoral scanners (S600 Arti, Zirkonzahn, and Ceramill map 600, Amann Girrbach GmbH). All digital scans were saved in the form of STL files and measurements were calculated using Geomagic analysis software. Two types of measurements were assessed on the casts: tooth‐ and arch‐level measurements. Absolute errors were calculated by subtracting the measurements on 3D printed, digital, and conventional stone casts from the measurements on the reference typodont cast. One‐way ANOVA was used for comparing different measurement errors between groups. Linear regression was performed to determine the association between different explanatory variables, and the average measurement errors (dependent variable) adjusted to reference cast measurements. Regression coefficients (B) and 95% confidence intervals (CI) were calculated.ResultsFor both 3D printed and digital casts, Dental Wings showed significantly greater error compared to other scanners and to the conventional stone cast at all measurements except arch lengths (in the 3D printed modality only), while conventional casts showed the lowest error. Error was significantly higher in intraoral than extraoral scanners (B = 0.009, 95% CI = 0.005, 0.02), and in arch level measurements than tooth level measurements (B = 0.03, 95% CI = 0.01, 0.04), and significantly lower in 3D printed than digital casts (B = –0.04, 95% CI = –0.05, –0.04). There were no statistically significant differences between measurement errors of both arches (maxillary and mandibular arches).ConclusionsExtraoral scanners showed higher accuracy than intraoral scanners, and 3D printed casts showed higher accuracy than their digital counterparts. Dental Wings scanner had the greatest measurement error.
On Catalan as a minority language: The case of Catalan laterals in Barcelonan Spanish
Authors: Davidson Justin 
Published: January 2022

AbstractThis investigation examines the variable production of alveolar laterals in Barcelonan Spanish as a case study evidencing the effects of language contact between a majority language, Spanish, and a minority language, Catalan. The Catalan‐Spanish speech community constitutes a rather unique case of majority‐minority language contact, particularly within the Spanish‐speaking world, as Catalan, though a minority language in Spain, is characterized by such a high degree of linguistic vitality, linguistic capital, and social prestige in the autonomous region of Catalonia that its status as a minority language is to a degree, questionable. I account for sociophonetic variability in the production of Barcelonan Spanish /l/ by a set of linguistic (phonological context, cognate status) and social factors (gender, age, style, language dominance) that support an analysis of lateral velarization as contact‐induced and situate this case of language contact as a natural or otherwise predictable outcome of this community's sociolinguistic and sociodemographic history, notably concerning changes in immigration patterns, language ideologies, and language use in the last century. Additionally, I highlight how the gradient nature of select sociophonetic variables uniquely conditions nuanced social indexation in the speech community, specifically in the absence of any one singular or discrete, community‐wide acoustic variant.
A long‐term study of temporal variation in wing feather mite (Acari: Astigmata) infestations on robins, Erithacus rubecula, in Nottinghamshire, UK
Authors: Peet R. , Kirk A. , Behnke J. M. 
Published: January 2022

AbstractEuropean robins (Erithacus rubecula) were mist netted and assessed for wing feather mite infestations in north‐east Nottinghamshire, England from June 1998 until March 2014. We analysed records of 899 first capture birds using three measures of infestation: prevalence of mites (% showing evidence of infestation), number of wing feathers infested with mites on one wing (NIWF), and the total mite infestation score (TOTMIS). The latter is the sum of scores (range 0–4) allocated to each of the 19 flight feathers on the assessed wing. The overall prevalence of infestation was 90.9% (95% confidence limits = 88.19–93.02), and average NIWFs and TOTMIS (±sem) were 6.0 ± 0.15 and 6.5 ± 0.23, respectively. All three measures varied significantly between age classes of birds, but not between the sexes, and varied markedly between months of the year. TOTMIS values were highest in late winter/early spring months and then dropped markedly in May to a low in summer months (usually by August), the dip in abundance of mites coinciding with the breeding season of robins. The best mixed‐effects generalised statistical model was one that comprised month of capture and age of birds but there was also a highly significant negative correlation between TOTMIS values of individual birds and the mean monthly ambient temperature in the month of capture as well as that of the preceding month. The most parsimonious interpretation of our data is that the highly consistent dip in mite abundance on adult robins from spring to summer months reflects vertical transmission of mites to their nestlings/fledgelings. These results are discussed in the context of the biology of both hosts and mites.
Fayalite formation through hydrothermal experiments: Insights into early fluid‐assisted aqueous alteration processes on asteroids
Authors: Dobrică E. , Nuth J. A. , Brearley A. J. 
Published: January 2022

AbstractIn order to understand the effects of the earliest fluid‐assisted hydration processes on asteroids, we performed one hydrothermal experiment using three different reactants (FeO‐rich amorphous silicates, iron metal powder, and water) at conditions informed by our current state of knowledge of asteroidal alteration. This experiment provides, for the first time, clear evidence that the growth of fayalite can occur during hydrothermal alteration, as described previously in meteorites. These newly formed fayalite crystals are elongated and porous, similar to the ones described in CV3, CK, and ordinary chondrites. The results show that (1) fayalite could form even if chemical equilibrium was not reached in the experiment, at a water to rock mass ratio (0.4 W/R at the beginning of the experiment) higher than the values calculated to be thermodynamically viable at equilibrium (W/R > 0.2); (2) the composition and the texture of the reactants changed during the hydrothermal alteration process, suggesting that the reactants, especially the amorphous silicates, underwent dissolution and reprecipitation; (3) fayalite can form at low temperature (220 °C), which is at the transition between hydrothermal alteration and fluid‐assisted metamorphism in chondrites. The results are consistent with previous mineralogical observations and thermodynamic models, which suggest that fayalite crystals are formed on asteroidal parent bodies by the interaction between a hydrothermal fluid and disequilibrium assemblages that compose the pristine materials that condensed in the early solar nebula. This experiment suggests that two variables play a very important role in the formation of fayalite during the hydrothermal growth (W/R mass ratio and the fluid composition). These results are similar to the recent observations of the fine‐grained matrix of ordinary chondrites.
Species divergence with gene flow and hybrid speciation on the Qinghai–Tibet Plateau
Authors: Wu Shengdan , Wang Yi , Wang Zefu , Shrestha Nawal , Liu Jianquan 
Published: January 2022

SummaryThe Qinghai–Tibet Plateau (QTP) sensu lato (sl), comprising the platform, the Himalaya and the Hengduan Mountains, is characterized by a large number of endemic plant species. This evolutionary cradle may have arisen from explosive species diversification because of geographic isolation. However, gene flow has been widely detected during the speciation processes of all groups examined, suggesting that natural selection may have also played an important role during species divergence in this region. In addition, natural hybrids have been recovered in almost all species‐rich genera. This suggests that numerous species in this region are still ‘on the speciation pathway to complete reproductive isolation (RI)’. Such hybrids could directly develop into new species through hybrid polyploidization and homoploid hybrid speciation (HHS). HHS may take place more easily than previously thought through alternate inheritance of alleles of parents at multiple RI loci. Therefore, isolation, selection and hybridization could together have promoted species diversification of numerous plant genera on the QTP sl. We emphasize the need for identification and functional analysis of alleles of major genes for speciation, and especially encourage investigations of parallel adaptive divergence causing RI across different lineages within similar but specific habitats in this region.
Q‐Switched 1064‐nm Nd: YAG laser versus fractional carbon dioxide laser for post acne scarring: A split‐face comparative study
Authors: Sabry Hanan Hassan , Hegazy Mohammed Saad , Ahmed Eman , Salem Rehab Mohammed 
Published: January 2022

AbstractObjectivesMany treatment modalities are available for post acne scarring. However, the response to the treatment is extremely variable among patients.AimThe aim of this study was to compare the efficacy and safety of Q‐switched Nd: YAG (1064 nm) and fractional CO2 (10,600 nm) lasers in the treatment of atrophic post acne scars.MethodsThis study included 20 patients with atrophic facial post acne scars graded according to Sharquie's score. All subjects received four sessions of laser treatment with a 4‐week interval between the sessions. The study was designed as a double‐blinded, comparative, split‐face study applying Q‐switched 1064‐nm Nd:YAG laser to the right side of the face and fractional CO2 laser to the left side.ResultsQ‐switched 1064‐nm Nd: YAG laser achieved significantly higher improvement percentage when compared to fractional CO2 lasers (33.33% versus 17.37% Sharquie's score reduction, respectively). There was a significant negative correlation between the percentages of improvement and the patients’ age on both sides and a significant positive correlation with the baseline Sharquie scores on both sides.ConclusionQ‐Switched 1064‐nm Nd: YAG laser could be a promising safe option for the management of atrophic post acne scars.
Matrix remodeling‐associated protein 8 is a marker of a subset of cancer‐associated fibroblasts in pancreatic cancer
Authors: Ichihara Ryosuke , Shiraki Yukihiro , Mizutani Yasuyuki , Iida Tadashi , Miyai Yuki , Esaki Nobutoshi , Kato Akira , Mii Shinji , Ando Ryota , Hayashi Masamichi , Takami Hideki , Fujii Tsutomu , Takahashi Masahide , Enomoto Atsushi 
Published: January 2022

AbstractCancer‐associated fibroblasts (CAFs), a compartment of the tumor microenvironment, were previously thought to be a uniform cell population that promotes cancer progression. However, recent studies have shown that CAFs are heterogeneous and that there are at least two types of CAFs, that is, cancer‐promoting and ‐restraining CAFs. We previously identified Meflin as a candidate marker of cancer‐restraining CAFs (rCAFs) in pancreatic ductal adenocarcinoma (PDAC). The precise nature of rCAFs, however, has remained elusive owing to a lack of understanding of their comprehensive gene signatures. Here, we screened genes whose expression correlated with Meflin in single‐cell transcriptomic analyses of human cancers. Among the identified genes, we identified matrix remodeling‐associated protein 8 (MXRA8), which encodes a type I transmembrane protein with unknown molecular function. Analysis of MXRA8 expression in human PDAC samples showed that MXRA8 was differentially co‐expressed with other CAF markers. Moreover, in patients with PDAC or syngeneic tumors developed in MXRA8‐knockout mice, MXRA8 expression did not affect the roles of CAFs in cancer progression, and the biological importance of MXRA8+ CAFs is still unclear. Overall, we identified MXRA8 as a new CAF marker; further studies are needed to determine the relevance of this marker.
A catalogue of semigroup properties for integral operators with Fox–Wright kernel functions
Authors: Fernandez Arran , Özarslan Mehmet Ali , Kürt Cemaliye 
Published: January 2022

AbstractThe Fox–Wright function is a very general form of function, covering many families of special functions as particular cases. Any special function can be used as a kernel for a fractional integral operator, but which of these operators will satisfy desiderata such as a semigroup property for composition? This paper provides a rigorous categorisation of all such fractional integral operators which have a semigroup property in any of their parameters. We discover that nearly all possible semigroup properties arise from the Chu–Vandermonde identity, with the Prabhakar fractional calculus emerging as one special case. For any integral operator with such a semigroup property, it is possible to construct a complete model of fractional calculus, including both integral and derivative operators which interact with each other in a natural way.
Teaching evidence‐based practice: Knowledge to implementation in a BSN program, part 2
Authors: Ruppel Kelly J. , Bone Beverley A. 
Published: January 2022

AbstractBackgroundNursing education at the undergraduate level has started teaching the process of research integration through evidence‐based practice (EBP) implementation rather than solely focusing on teaching nursing research. This is Part 2 of a two‐part series.AimsTo discuss strategy on how to teach undergraduate nursing students the process of implementing EBP over two courses and to assess their learning outcomes. This article focuses on Course 2, Leadership and Management, which takes place during senior year and builds on student learning from their junior year through application of an EBP capstone project.MethodsThe American Association of Colleges of Nursing's Essentials of Baccalaureate Education for Nursing Practice (2008) was used to guide the discussion and course development. An anonymous survey was used to measure the level of student perceived achievement of the learning objectives related to EBP. Students responded to statements using a 5‐point Likert scale for level of agreement (1 = strongly disagree to 5 = strongly agree).ResultsIn Course 2, Leadership and Management, senior year students focused on the remaining EBP steps (four through six) and completed an EBP capstone project with a nurse manager. A total of 83 students responded to the anonymous evaluation survey, and mean learning objective scores were 4.0 or above, indicating a high degree of perceived level of achievement.Linking Evidence to ActionTeaching the EBP process with active learning strategies over two courses enhances student learning.