bluuebunny/crossref_metadata_2025_split huggingface dataset:
Can labour market institutions mitigate the China syndrome? Evidence from regional labour markets in Europe
Authors: Hennig Jan‐Luca 
Published: April 2022

AbstractThis paper investigates how labour market regulations alter the adverse impact of rising import competition from China in European local labour markets between 1997 and 2006. The paper constructs measures of regional exposure to Chinese imports based on previous literature and on regional labour market frictions exploiting involuntary labour reallocations. Taking into account the endogeneity of import competition and its interaction with labour market regulations, the paper finds that regions more exposed to the rise of China have suffered from a reduction in manufacturing employment shares. This shock grows larger with regional labour market frictions; hence, it exacerbates the impact of trade shock on employment. Moreover, the paper finds that employment in public services, and not in construction or private services sector, absorbed the negative shock to the manufacturing sector. The unemployment rate, the labour force participation rate and wages in all sectors are unresponsive to import competition from China.
Middle East respiratory syndrome coronavirus (MERS‐CoV) infection: Analyses of risk factors and literature review of knowledge, attitude and practices
Authors: Rahman Arifur , Sarkar Atanu 
Published: April 2022

AbstractThe study aimed to explore the risk factors for MERS‐CoV infection and systematic review of knowledge, attitudes and practices (KAP) with regard to MERS‐CoV among the health care workers (HCWs) and the general population. The World Health Organization's MERS‐CoV line list (January 2013–January 2020) of the Kingdom of Saudi Arabia (KSA) was analysed. A Poisson regression model was used to calculate the univariate relative risk of outcomes to each potential risk factor, p‐values and 95% confidence intervals. An electronic literature search was conducted to assess knowledge, attitudes and practices of the HCWs and general population of the KSA, with regards to transmission of the infection, risk factors and preventative measures. The line list analysis shows that age, gender, comorbidity, exposure to camels and camel milk consumption were associated with an increased risk of fatality; however, year‐wise analysis did not show any decline. Over the years, the mean durations between the symptom onset and hospitalization; the hospitalization and laboratory confirmation have reduced. The review of literature shows that the health care workers and the general population had inadequate knowledge about MERS‐CoV, lacked motivation and were disconnected from the health authorities. The WHO line list provides information on risk factors for MERS‐CoV, KAP analysis helps to know the potential underlying factors. The literature review shows that continuous education for HCWs and increasing public awareness can help effectively manage future MERS‐CoV.
Modeling for Scenarios for Stock Recovery of Russian Sturgeon Acipenser gueldenstaedtii in the Sea of Azov in the Absence of Natural Reproduction
Authors: Bulgakova T. I. , Kulba S. N. , Piatinskii M. M. 
Published: April 2022

Abstract—
A new model describing the dynamics of sturgeon (Acipenseridae) population unable to recover or ranked as depleted is proposed as a depleted artificially-stocking population (DAP) model. The model composed of two submodels is implemented in the R language. One of the submodels provides the opportunity to adjust the appropriate parameters used in a global model (the rate of natural mortality of a mature fish stock in a population and the artificial reproduction efficiency) with the optimization-based methods, while the second submodel deals with various scenarios for fish stock recovery over the forecast period. Scenarios are characterized by two parameters: the quantity of juvenils released by sturgeon hatcheries and the commercial fish catch decline caused by the illegal fishing practices and the fish catch for science-based targets. The estimates for the pattern of the Russian sturgeon Acipenser gueldenstaedtii in the Sea of Azov indicate that its stock may be recovered to the target level of 10 thousand tons with the baseline and optimistic scenarios by 2037—2048 relative to the artificial reproduction efficiency and the extent of illegal, unreported, and unregulated fishing. With respect to pessimistic scenarios, the stocks are not expected to recover.
IOLite: phase 1b trial of doublet/triplet combinations of dostarlimab with niraparib, carboplatin–paclitaxel, with or without bevacizumab in patients with advanced cancer
Authors: Yap Timothy A , Bessudo Alberto , Hamilton Erika , Sachdev Jasgit , Patel Manish R , Rodon Jordi , Evilevitch Lena , Duncan Meghan , Guo Wei , Kumar Sujatha , Lu Sharon , Dezube Bruce J , Gabrail Nashat 
Published: April 2022

BackgroundDoublet combination therapies targeting immune checkpoints have shown promising efficacy in patients with advanced solid tumors, but it is unknown if rational triplet combinations will be well tolerated and associated with improved antitumor activity. The objective of this trial was to determine the recommended phase 2 doses (RP2Ds) and to assess the safety and efficacy of the programmed cell death protein 1 (PD-1) inhibitor dostarlimab in combination with (1) the poly(ADP-ribose) polymerase inhibitor niraparib with or without vascular endothelial growth factor inhibitor bevacizumab or (2) carboplatin–paclitaxel chemotherapy with or without bevacizumab, in patients with advanced cancer.MethodsIOLite is a multicenter, open-label, multi-arm clinical trial. Patients with advanced solid tumors were enrolled. Patients received dostarlimab in combination with niraparib with or without bevacizumab or in combination with carboplatin–paclitaxel with or without bevacizumab until disease progression, unacceptable toxicity, or withdrawal from the study. Prespecified endpoints in all parts were to evaluate the dose-limiting toxicities (DLTs), RP2Ds, pharmacokinetics (PKs), and preliminary efficacy for each combination.ResultsA total of 55 patients were enrolled; patients received dostarlimab and: (1) niraparib in part A (n=22); (2) carboplatin–paclitaxel in part B (n=14); (3) niraparib plus bevacizumab in part C (n=13); (4) carboplatin–paclitaxel plus bevacizumab in part D (n=6). The RP2Ds of all combinations were determined. All combinations were safe and tolerable, with no new safety signals observed. DLTs were reported in 2, 1, 2, and 0 patients, in parts A–D, respectively. Preliminary antitumor activity was observed, with confirmed Response Evaluation Criteria in Solid Tumors v1.1 complete/partial responses reported in 4 of 22 patients (18.2%), 6 of 14 patients (42.9%), 4 of 13 patients (30.8%), and 3 of 6 (50.0%) patients, in parts A–D, respectively. Disease control rates were 40.9%, 57.1%, 84.6%, and 83.3%, in parts A–D, respectively. Dostarlimab PK was unaffected by any combinations tested. Coadministration of bevacizumab showed no impact on niraparib PKs. The overall mean PD-1 receptor occupancy was 99.0%.ConclusionsDostarlimab was well tolerated in both doublet and triplet regimens tested, with promising antitumor activity observed with all combinations. We observed higher disease control rates in the triplet regimens than in doublet regimens.Trial registration numberNCT03307785.
Pollination ecology of lowbush blueberry (Vaccinium angustifoliumAiton) in an island ecosystem
Authors: Noone Rachel E. , Doucet Stéphanie M. , Jones Patricia L. 
Published: April 2022

Plant pollination is influenced by plant traits, pollinator community, plant community, and abiotic conditions. Island ecosystems, which often have reduced pollinator communities, provide unique insights into pollination ecology. Lowbush blueberry, Vaccinium angustifolium Aiton, has predominantly been studied in managed agricultural areas with introduced honeybees. We examined diurnal and nocturnal pollination of unmanaged lowbush blueberry patches on an 80 ha island in New Brunswick without honeybees. We restricted pollinator access to blueberry stems in five different treatments. Using mesh bags, we made stems accessible to pollinators 24 h a day (positive control), only during the day, only at night, or never (negative control), with an additional sham control. Blueberry stems accessible only to diurnal visitors had 70.55% fruit set and a mean 7.33 viable seeds per fruit. Stems accessible only to nocturnal visitors had 63.76% fruit set and 5.87 viable seeds, significantly higher than the continuously bagged negative control stems. The most common diurnal insects observed visiting flowers were bumblebees and two wasp species. Insects collected from plants at night were beetles and flies. There was substantial variation between blueberry patches in fruit set and fruit size. We examined whether flower color could be driving patch differences in pollination, and quantified flower color using spectrophotometry. We found no effect of flower color on metrics of pollination. As well as demonstrating substantial nocturnal pollination, we record unusually high fruit set, especially for an island without managed bees. We discuss some of the potential drivers of this high fruit set.
Undermining environmental assessment laws: post-assessment amendments for mines in British Columbia, Canada, and potential impacts on water resources
Authors: Collison Ben R. , Reid Patrick A. , Dvorski Hannah , Lopez Mauricio J. , Westwood Alana R. , Skuce Nikki 
Published: April 2022

In British Columbia (BC), Canada, there is increased attention on mines and their impacts on water resources. In BC, many proposed mines undergo provincial environmental assessment (EA), which predicts a mine’s risks and involves government oversight and public engagement. After approval, mines can apply for amendments that alter the project’s undertakings, including in ways that may harm water resources. We examined all amendment documents for mines undergoing provincial EA in BC from 2002 to 2020. Of the 23 approved mines, 15 (65%) requested a total of 49 amendments, of which 98% were approved. Most mines applied for their first amendment within 3 years of approval. We deemed 20 of the approved amendments (associated with 10 projects) likely to have negative impacts on water resources, including changes to effluent discharge, increased volume of water extraction, or degradation of fish habitat. Amendment applications and approval documents lacked specific, quantitative information to reinforce claims or decisions. We present the first known summary of EA amendments in any jurisdiction. Given that most mines in BC receive amendments, and many are related to water, we express concern that amendment processes increase risk to water resources without meeting standards of evidence and public scrutiny required by the regular EA process.
Stratified spaces, directed algebraic topology, and state-sum TQFTs
Authors: Lee I. J. , Yetter D. N. 
Published: April 2022

We apply the theory of directed topology developed by Grandis [Directed homotopy theory, I. The fundamental category, Cah. Topol. Géom. Différ. Catég. 44 (2003) 281–316; Directed Algebraic Topology: Models of Non-Reversible Worlds, New Mathematical Monographs, Vol. 13 (Cambridge University Press, Cambridge, 2009)] to the study of stratified spaces by describing several ways in which a stratification or a stratification with orientations on the strata can be used to produce a related directed space structure. This description provides a setting for the constructions of state-sum TQFTs with defects of [A. L. Dougherty, H. Park and D. N. Yetter, On 2-dimensional Dikjgraaf-Witten theory with defects, J. Knot Theory Ramifications 25(5) (2016) 1650021, doi:10.1142/S0218216516500218 ; I. J. Lee and D. N. Yetter, Dijkgraaf–Witten type invariants of Seifert surfaces in 3-manifolds, J. Knot Theory Ramifications 26(5) (2017) 1750026, doi:10.1142/S0218216517500262 ], which we extend to a similar construction of a Dijkgraaf–Witten type TQFT in the case where the defects (lower-dimensional strata) are not sources or targets, but sources on one side and targets on the other, according to an orientation convention.
RESEARCH ON THE APPLICATION OF SPORTS BIOMECHANICS IN IMPROVING ATHLETES’ PHYSICAL FITNESS IN TRACK AND FIELD PHYSICAL EDUCATION COURSES
Authors: WANG BO 
Published: April 2022

Object: In this paper, eight male basketball players were tested for physical fitness using the method of sports biology. The content of the physical examination is the isokinetic muscle strength of the shoulder joint. This paper aims to investigate the effect of shoulder isokinetic muscle strength on athletic performance. Methods: This paper uses the principles of sports biology and the isokinetic muscle strength test system to measure the shoulder torque and fatigue index of eight basketball players. At the same time, this paper analyzes the obtained data using the method of mathematical statistics. Results: There were significant differences in the test data of eight male basketball players (P < 0.05). The fatigue of basketball players is mainly in the middle and late stages of sports. At average speed, the fatigue index of the shoulder is the lowest at 180°/s. Conclusion: Basketball players have stronger shoulder extensors than flexors. The balance of strength in the shoulder flexors is greater than the balance in the extensors.
Auto-Icon+
: An Automated End-to-End Code Generation Tool for Icon Designs in UI Development
Authors: Feng Sidong , Jiang Minmin , Zhou Tingting , Zhen Yankun , Chen Chunyang 
Published: April 2022

Approximately 50% of development resources are devoted to user interface (UI) development tasks [
9
]. Occupying a large proportion of development resources, developing icons can be a time-consuming task, because developers need to consider not only effective implementation methods but also easy-to-understand descriptions. In this article, we present
Auto-Icon+
, an approach for automatically generating readable and efficient code for icons from design artifacts. According to our interviews to understand the gap between designers (icons are assembled from multiple components) and developers (icons as single images), we apply a heuristic clustering algorithm to compose the components into an icon image. We then propose an approach based on a deep learning model and computer vision methods to convert the composed icon image to fonts with descriptive labels, thereby reducing the laborious manual effort for developers and facilitating UI development. We quantitatively evaluate the quality of our method in the real-world UI development environment and demonstrate that our method offers developers accurate, efficient, readable, and usable code for icon designs, in terms of saving 65.2% implementing time.
NEUSTON DIVERSITY AND DENSITY AS BIOINDICATOR FOR WATER QUALITY
Authors: Nurza Imam Safir Alwan , Vania Jesslyn Gitta , Reynaldi Muhammad Khatami , Rasyid Zaki Gunawan , Komala Ratna 
Published: April 2022

Lakes and waterfalls are freshwater ecosystems having important roles in ecology, tourism and economic aspects. Among living organisms existing in lakes and waterfalls is neuston. Neuston lives on the surface and below the surface of the waters. Neuston can be used as a bioindicator for water quality due to the neuston’s high level of sensitivity toward pollutants. The purpose of this study was to determine the density and diversity of neuston as a bioindicator for water quality in the lake and waterfall. The methods used were survey and observation. The study was carried out by using purposive sampling at two locations, namely the lake and waterfall of Situ Gunung, Sukabumi, with a sampling area of 1 x 1 m2. The samples obtained were put into bottles containing 70% alcohol to be identified in the laboratory. Environmental parameters measured were air and water temperature, water pH, water depth, turbidity, water flow velocity, dissolved oxygen, substrate and weather conditions. The results obtained indicated that the lake and waterfall of Situ Gunung, Sukabumi had highest neuston densities were shown by Gerris lacustris and Dineutus assimilis. The lowest neuston densities were shown by Metrobates hesperius, Gerris comatus, Aquarius remiges and Trepobates pictus. This study showed that the environmental parameters of the lake and waterfall of Situ Gunung, Sukabumi can still support the survival of the existing neustons.
A Reflexão no último livro de Giannotti
Authors: Figueiredo Vinicius Berlendis de 
Published: April 2022

Em seu último livro, Heidegger/Wittgenstein — Confrontos (2020), José Arthur Giannotti conclui sua apropriação filosófica da obra de L. Wittgenstein, iniciada com A apresentação do mundo (1995). Examino neste artigo de que modo o corpo a corpo com o filósofo austríaco fez Giannotti rever questões com que se ocupara ao longo de seus trabalhos sobre Marx, em especial no que diz respeito à questão pelo estatuto do lógos prático e da Reflexão.
O lugar da intersubjetividade no Sistema do idealismo transcendental de Schelling
Authors: Cunha João Geraldo Martins da 
Published: April 2022

Neste trabalho, pretendo oferecer uma interpretação da “Segunda proposição” da filosofia prática — Capítulo IV do Sistema do idealismo transcendental (1800). A partir dessa delimitação textual, minha hipótese não vai além de uma sugestão segundo a qual a relação de interação recíproca e indireta entre as autoconsciências ocupa um “lugar” estratégico no argumento de Schelling, uma vez que, através dela, pelo menos em princípio, dois problemas seriam resolvidos: (1) aquele acerca da contradição enraizada no limite originário dos atos transcendentais de autoconstituição da inteligência como consciência individual e livre; (2) e aquele acerca da articulação entre filosofia teórica e filosofia prática.
DOCK4 Regulation of Rho GTPases Mediates Pulmonary Vascular Barrier Function
Authors: Yazbeck Pascal , Cullere Xavier , Bennett Paul , Yajnik Vijay , Wang Huan , Kawada Kenji , Davis Vanessa M. , Parikh Asit , Kuo Andrew , Mysore Vijayashree , Hla Timothy , Milstone David S. , Mayadas Tanya N. 
Published: April 2022

Background:
The vascular endothelium maintains tissue-fluid homeostasis by controlling the passage of large molecules and fluid between the blood and interstitial space. The interaction of catenins and the actin cytoskeleton with VE-cadherin (vascular endothelial cadherin) is the primary mechanism for stabilizing AJs (adherens junctions), thereby preventing lung vascular barrier disruption. Members of the Rho (Ras homology) family of GTPases and conventional GEFs (guanine exchange factors) of these GTPases have been demonstrated to play important roles in regulating endothelial permeability. Here, we evaluated the role of DOCK4 (dedicator of cytokinesis 4)—an unconventional Rho family GTPase GEF in vascular function.

Methods:
We generated mice deficient in DOCK4‚ used DOCK4 silencing and reconstitution approaches in human pulmonary artery endothelial cells‚ used assays to evaluate protein localization, endothelial cell permeability, and small GTPase activation.

Results:
Our data show that DOCK4-deficient mice are viable. However, these mice have hemorrhage selectively in the lung, incomplete smooth muscle cell coverage in pulmonary vessels, increased basal microvascular permeability, and impaired response to S1P (sphingosine-1-phosphate)–induced reversal of thrombin-induced permeability. Consistent with this, DOCK4 rapidly translocates to the cell periphery and associates with the detergent-insoluble fraction following S1P treatment, and its absence prevents S1P-induced Rac-1 activation and enhancement of barrier function. Moreover, DOCK4-silenced pulmonary artery endothelial cells exhibit enhanced basal permeability in vitro that is associated with enhanced Rho GTPase activation.

Conclusions:
Our findings indicate that DOCK4 maintains AJs necessary for lung vascular barrier function by establishing the normal balance between RhoA (Ras homolog family member A) and Rac-1–mediated actin cytoskeleton remodeling, a previously unappreciated function for the atypical GEF family of molecules. Our studies also identify S1P as a potential upstream regulator of DOCK4 activity.
Abstract 13311: A Novel Senolytic Drug, Seno-7284 Ameliorates Age-Related Cardiometabolic Diseases
Authors: Katsuumi Goro , Suda Masayoshi , Shimizu Ippei , Yoshida Yohko , Hsiao Yung-Ting , Hsiao Chien Lun , Furuuchi Ryo , Minamino Tohru 
Published: April 2022

Cellular senescence plays a pivotal role in aging and age-related disorders. Recently, it was shown that elimination of senescent cells, so-called "senolysis" has the potential to become a next generation therapy for age-related disorders including cardio-metabolic diseases. However, currently there is no senolytic drug available in clinical settings. The present study was aimed to identify a novel senolytic reagent effective for cardiometabolic diseases in compounds already available in clinical settings.
We demonstrate a compound called "Seno-7284" exhibits senolytic effect in murine models of type 2 diabetes, atherosclerosis, progeroid and chronological aged mice. Seno-7284 reduced the accumulation of senescent cells in visceral adipose tissue of diabetic mice as senescence-associated-beta-galactosidase (SA-beta-gal) staining exhibits. This associated with the suppression in systemic glucose intolerance, and adipose tissue inflammation in four weeks after the administration of Seno-7284. Administrating Seno-7284 for two weeks also suppressed the progression of atherosclerosis in ApoE-KO mice. This drug significantly improved the lifespan of Zm-KO mice by administering it from 12 weeks old. Administration of Seno-7284 from 50 week-old for 20 weeks improves physical function in chronological aged mice. Further analysis including single cell RNA-seq suggested that Seno-7284 stimulates endogenous senolytic function of NK cells and CD8+ T cells.
Our results indicate Seno-7284 mediates its biological effects by inducing senolysis in murine aging models. Seno-7284 would become promising therapies for age-related disorders.
Abstract 13614: Pulmonary Artery Catheter Guided Therapy of Cardiogenic Shock is Associated With Lower Short-Term Mortality: A Systematic Review and Meta-Analysis
Authors: Vyas Rohit , Mhanna Mohammed , Nazir Salik , Holtzapple Zachary , Brohi Zafrullah , Khouri Samer , Eltahawy Ehab 
Published: April 2022

The utility of pulmonary artery catheterization (PAC) in treatment of cardiogenic shock (CS) is questionable. In this meta-analysis we aimed to evaluate the impact of PAC guided treatment on survival in CS patients.
We performed a comprehensive literature search of multiple databases for studies that evaluated the clinical utility of PAC-guided management versus standard care for patients with CS. The primary outcome of interest was short-term mortality. The secondary outcomes were the use of mechanical circulatory support (MCS) and inotropes. Pooled relative risk (RR) and corresponding 95% confidence intervals (CIs) were calculated and combined using random effects model meta-analysis.

A total of 9 studies including 364,001 patients with CS (29609 managed with PAC guided therapy vs. 334392 managed with slandered of care) were included in the final analysis. There was a significant difference in short-term mortality favoring PAC guided management (RR:0.83; 95% CI:0.76-0.92;
P
<0.00001). Standard of care guided management was associated with higher use of MCS and inotropic agents (RR:1.30; 95% CI:1.15-1.46;
P
<0.0001) and (RR:1.18; 95% CI:1.09-1.29;
P
<0.001) respectively.

Our meta-analysis demonstrates that PAC-guided therapy for patients with CS was associated with lower short-term mortality and a lower likelihood to use MCS and inotropes with their potential associated complications. Further randomized clinical trials are needed to evaluate the utility of PAC as an adjunct tool in the management of CS.