bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect ofHelicobacter pylorion immunotherapy is gaining more attention
Authors: Shi Yanyan , Zheng Huiling , Guo Zhijun , Deng Ruiyi , Yu Wei , Song Yahan , Ding Shigang 
Published: August 2022

AbstractBackgroundImmunotherapy, especially immune checkpoint inhibitors, has been widely used in tumor therapy and have shown ideal clinical efficacy. However, some cancers still do not respond to PD‐1/PD‐L1 blockade therapy effectively.Helicobacter pyloriinfection might affect the curative effect of immunotherapy while it is rarely reported. We aimed to visualize the research hotspots and trends ofH. pyloriand immunotherapy using a bibliometric analysis to help understand the future development of basic and clinical research.MethodsThe relevant publications onH. pyloriand immunotherapy were searched on April 20, 2022, in the Web of Science Core Collection Database (WOSCC). The document types were limited to articles and reviews. The VOSviewer 1.6.16 software was used to assess the co‐authorship, co‐occurrence, citation of countries, institutions, authors, journals, and hotspot keywords. The research status and trend change ofH. pyloriand immunotherapy were analyzed by bibliometric analysis.ResultsA total of 95 studies authored by 561 researchers were eventually included in this study. The majority of the retrieved studies were 55 (58%) original research articles. China conducted the greatest number of studies, followed by USA and Italy. The related topics included the following three aspects: the relationship between microorganisms and cancer, the relationship between gastric cancer and immunity, and the relationship betweenH. pyloriand immunotherapy, including purified/cloned components ofH. pyloriacting as efficient adjuvant to boost tumor responses andH. pyloriinfection which modulate host immune responses and impact on the efficacy of antitumor immunity initiated by immune checkpoint inhibitors. The timing diagram revealed that the current research hotspots focused on effects of microorganisms on immunotherapy.ConclusionThe effect ofH. pylorion cancer immunotherapy is getting more and more attention in these years. It still remains uncertain, and more studies are needed in the future.
Genetic associations with lymphomas in Polish patients: A pooled‐DNA genome‐wide association analysis
Authors: Paszkiewicz‐Kozik Ewa , Kluska Anna , Piątkowska Magdalena , Bałabas Aneta , Żeber‐Lubecka Natalia , Karczmarski Jakub , Goryca Krzysztof , Kulecka Maria , Wojciechowska‐Lampka Elżbieta , Osiadacz Włodzimierz , Romejko‐Jarosińska Joanna , Świerkowska Monika , Paziewska Agnieszka , Ambrożkiewicz Filip , Walewski Jan , Mikula Michał , Ostrowski Jerzy 
Published: August 2022

AbstractSeveral single nucleotide polymorphisms (SNPs) associated with susceptibility to Hodgkin lymphoma (HL) and diffuse large B‐cell lymphoma (DLBCL) have been identified. The aim of this study was to identify susceptibility loci for HL and DLBCL in Polish patients. Altogether, DLBCL (n = 218 and HL patients (n = 224) and healthy individuals (n = 1181) were recruited. Lymphoma diagnosis was based on standard criteria. Genome‐wide association study (GWAS) was performed using pooled‐DNA samples on llumina Infinium Omni2.5 Exome‐8 v1.3, and selected loci were replicated by TaqMan SNP genotyping of individuals. GWAS detected thirteen and seven SNPs associated with DLBCL and HL, respectively. In the replication study, six and seven SNPs reached significance after correction for multiple testing in the DLBCL and HL cohorts, respectively. One and four SNPs associated with DLBCL and HL, respectively, were localized within, and two SNPs—near the major histocompatibility complex (MHC) region. In conclusion, the majority of loci associated with HL and DLBCL aetiology in previous studies have potential roles in immune function. Our pooled‐DNA GWAS enabled the identification of several susceptibility loci for DLBCL and HL in the Polish population; some of them were mapped within or adjacent to the MHC, and other associated SNPs were located outside the MHC.
Association between the interferon‐γ +874 T/A polymorphism and susceptibility to systemic lupus erythematosus and rheumatoid arthritis: A meta‐analysis
Authors: Lee Young Ho , Song Gwan Gyu 
Published: August 2022

AbstractWe aimed to determine whether the interferon (IFN)‐γ +874 T/A polymorphism (rs2430561) is associated with susceptibility to systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). A meta‐analysis was conducted to assess the association between the IFN‐γ +874 T/A polymorphism and SLE or RA using allele contrast, homozygous contrast, recessive, and dominant models. A total of nine studies (six on SLE and three on RA), involving 1839 patients and 2272 controls, were included in the meta‐analysis. The meta‐analysis revealed a significant association between SLE and the TT genotype of the IFN‐γ +874 T/A polymorphism (odds ratio [OR] = 0.751, 95% confidence interval [CI] = 0.634–0.899, p = .001), and stratification by ethnicity indicated an association between the IFN‐γ +874 TT genotype and the Asian population. The analysis also revealed a significant association between SLE and the TT + TA genotype of the IFN‐γ +874 T/A polymorphism in Arab populations (OR = 1.598, 95% CI = 1.053–2.425, p = .028). However, no association between the IFN‐γ +874 T/A polymorphism and RA was found using allele contrast, recessive, dominant or homozygous contrast models in all study subjects and ethnic groups. This meta‐analysis demonstrated that the IFN‐γ +874 T/A polymorphism is associated with susceptibility to SLE in Asian and Arab populations.
Turnover intention and retention of newly licensed nurses in their first job: A longitudinal study
Authors: Chang Hyoung Eun , Cho Sung‐Hyun 
Published: August 2022

AbstractAimTo examine newly licensed nurses’ retention in their first job and factors related to their turnover.BackgroundNewly licensed nurses have a high turnover rate within three years of entering their first job.IntroductionThe factors affecting newly licensed nurses' turnover should be identified and prevented.MethodsThis longitudinal study tracked newly licensed nurses for three years. Data were collected online, and nurses could participate four times in the survey. The Kaplan–Meier method was used to estimate survival curves and to present nurses’ retention. Cox proportional hazards regression model was used to analyze factors related to turnover.ResultsThe estimated survival probabilities in nurses’ first job at one, two, and three years were 0.927, 0.778, and 0.686, respectively. Nurses who reported turnover intention within one year in the first survey had significantly lower survival probabilities than those who did not have turnover intention. Turnover was more likely among male nurses. Turnover intention was associated with a significant increased likelihood of nurses leaving their first job.DiscussionMore than one third of newly licensed nurses left their first job within three years of employment. To reduce nurses’ turnover, it is necessary to understand and manage turnover intention in advance. Specific steps should be taken to address male nurses’ turnover.ConclusionsTurnover intention was the most powerful predictor of turnover. Further research should investigate reasons for turnover intention at the beginning of employment, and strategies to prevent turnover should be developed before nurses enter the workforce.Implications for nursing and health policyNewly licensed nurses with turnover intention at the beginning of their career should receive particular attention, and wellness programs should be prepared to promote retention.
COVID‐19 risk perception and associated factors in older adults in southern Ethiopia
Authors: Debancho Tadese Dea , Gebeyehu Eyasu Gambura , Gelgelu Temesgen Bati 
Published: August 2022

AbstractBackgroundCOVID‐19 remains a public health concern in lower income countries. Risk perception has been studied in different countries with different population groups. However, there have been few studies conducted risk perception on older adults and limited data from African continent. This study aimed to assess coronavirus disease low risk perception level and associated factors among older adults in Ethiopia.MethodsWe conducted a cross‐sectional study among older adults in Areka town, Wolaita Zone, Southern Ethiopia, from August 1, 2021, to August 30, 2021. Multi‐stage sampling method was applied to select study participants. The data were collected through a structured questionnaire with the mobile application created with Open Data Kit mobile.ResultsOverall, risk perception was fairly low. Risk perception was particularly low among individuals aged 65 to 74 years (AOR = 4.76, 95% CI: 2.35–9.64), poor practice on preventing coronavirus disease (AOR = 2.39, 95% CI: 1.51–3.78), with low trust level in medical professionals (AOR = 2.44, 95% CI: 1.45–4.10), no history of coronavirus disease (AOR = 6.45, 95%CI [2.02–20.58]), and poor perceived self‐efficacy for preventive practice (AOR = 2.25, 95% CI: 1.43–3.54).ConclusionsIn the current study area, the perception of risk of coronavirus disease was affected by age, perceived self‐efficacy, trust in medical professionals, preventive practice, and history of COVID‐19. The findings of this study would help lower income countries to generate evidence‐based policy decisions for older adults during the COVI‐D‐19 pandemic and future pandemic(s).
‘Staying strong’: A constructivist grounded theory of how registered nurses deal with the impact of trauma‐related events in rural acute care practice
Authors: Jahner Sharleen , Penz Kelly , Stewart Norma J. , Morgan Debra , Kulig Judith 
Published: August 2022

AbstractAims and objectivesThis study explored how Registered Nurses (RNs) in rural practice deal with psychologically traumatic events when living and working in the same rural community over time.BackgroundRural RNs who are exposed to trauma may be at high risk for psychological distress (e.g. secondary traumatic stress, vicarious trauma and post‐traumatic stress disorder), in the context of isolated practice and slower emergency response times.Design and methodsCharmaz's constructivist grounded theory methodology was chosen for this qualitative study. Purposeful sampling was used to recruit 19 RNs from six rural acute care hospitals. A total of 33 interviews were conducted with 19 face‐to‐face initial interviews, 14 follow‐up telephone interviews and 14 reflective journals. Adherence to the COREQ EQUATOR guidelines was maintained.ResultsParticipants were exposed to a multitude of trauma‐related events, with their main concern of being intertwined with events for life. They dealt with this by staying strong, which included relying upon others, seeking inner strength, attempting to leave the past behind and experiencing transformational change over time. Being embedded in the community left them linked with these trauma‐related events for life. Staying strong was a crucial element to their ability to cope and to face future events.ConclusionsThe psychological implications of trauma‐related events when working and living in rural acute care practice settings are significant and complex. Findings highlight the need for organizational support and processes and may contribute to improved psychological services and management practices.Relevance to clinical practiceKey learnings were that rural nurses, who live and work in the same community, experience psychological changes over time from traumatic events that stay with them for life; employers fail to recognise the seriousness of this issue and trauma‐informed policies with associated resources are lacking.
Carbon taxation: A review of the empirical literature
Authors: Köppl Angela , Schratzenstaller Margit 
Published: August 2022

AbstractIn view of the challenges posed by climate change and the increasingly ambitious climate targets around the world, the search for effective climate policy instruments is gaining momentum. Carbon pricing, for example, in the form of a carbon tax, and its effects are therefore attracting increasing attention in academic as well as policy discussions. We review the empirical effects of carbon taxes with regard to several impact dimensions commonly studied in the literature: environmental effectiveness, macroeconomic effects, impacts on competitiveness and innovation, distributional implications, and public acceptance. An increasing body of empirical studies shows that carbon taxes can effectively reduce carbon emissions or at least dampen their growth while not negatively affecting economic growth, employment, and competitiveness. The existing empirical evidence suggests that the distributional impact of carbon taxes depends on the type of energy use and the indicators to capture distributional effects, as well as on household characteristics. Lump‐sum transfers are shown to be better suited to mitigate regressive effects for lower incomes, while higher incomes benefit more from a reduction of labor taxes. Public acceptance of carbon taxes can be increased by providing public information, avoiding negative distributional effects, and channeling part of the revenues into "environmental projects."
Manual vacuum aspiration (women's MVA) for endometrial biopsy for patients with suspected endometrial malignancies
Authors: Saito Etsuko , Matsumoto Yoko , Nitta Satoshi , Fujino Saho , Tsuruga Tetsushi , Mori‐Uchino Mayuyo , Iwase Haruko , Kasamatsu Takahiro , Kugu Koji , Osuga Yutaka 
Published: August 2022

AbstractAimEndometrial biopsy is generally performed with a metal uterine curette sonde; however, recently, many types of vacuum aspirators are available, including the manual vacuum aspiration (MVA) system. We used the women's MVA system for endometrial sampling and evaluated its effectiveness in determining the presence of endometrial malignancy.MethodsForty‐seven samples were examined using the following procedures after measuring endometrial thickness by transvaginal ultrasonography: fractional curettage biopsy (Bx; 20 samples), total curettage under general anesthesia (T/C; 13 samples), and MVA (14 samples). The quality of the endometrial samples was classified into four types: 1–4, where 1 denoted poor and 4, good quality.ResultsThe mean score of the MVA group was significantly higher than that of the partial curettage biopsy group (p = 0.0065). No differences were observed between the MVA and total curettage groups (p = 1.00). When patients were divided into two groups according to endometrial thickness (<10 mm or ≥10 mm) and analyzed, both the MVA and T/C groups did not show a significant difference in their scores compared to the Bx group when the endometrial thickness was <10 mm. However, when the endometrial thickness was ≥10 mm, the MVA and T/C groups had significantly better scores than the Bx group (p = 0.0225 and p = 0.0244, respectively). Vagal reflex, as an adverse event, was observed only in two patients in the Bx group (2/20, 10%).ConclusionConsidering its quality and safety, Karman‐type MVA for endometrial sampling could be an alternative to fractional curettage using a metallic uterine curette sonde.
Safety and efficacy of levonorgestrel‐releasing intrauterine device in the treatment of atypical endometrial hyperplasia and early endometrial cancer
Authors: Hirata Toru , Kondo Eiji , Magawa Shoichi , Kubo‐Kaneda Michiko , Nii Masafumi , Yoshida Kenta , Maezawa Tadashi , Tabata Tsutomu , Ikeda Tomoaki 
Published: August 2022

AbstractAimTo investigate the recurrence rate, live‐birth rate, and treatment outcomes of levonorgestrel‐releasing intrauterine device (LNG‐IUD) for the management of atypical endometrial hyperplasia (AEH) or Grade‐1 endometrial cancer (EC) in patients who desire fertility‐sparing treatment and those seeking conservative treatment without fertility preservation.MethodsWe prospectively enrolled nine patients from a single institution between April 2009 and September 2013 who were followed up for 60 months after LNG‐IUD insertion.ResultsThe median patient age was 35 (range: 29–39) years. The overall recurrence rate was 56% (5/9). The median interval between removal of the LNG‐IUD and recurrence was 20.5 (range: 2–30) months. Three of the nine patients had Grade‐1 EC, and six had AEH. The response rates to the LNG‐IUD in patients with Grade‐1 EC and AEH were 66% and 100%, respectively. Four patients (three with AEH, one with Grade‐1 EC) experienced recurrence 6 months after MPA treatment and all 4 (100%) had complete response. Eight patients desired fertility preservation, of which 37% (3/8) conceived after receiving fertility treatment and 25% (2/8) had a live birth; the remaining three had previously received MPA for 6 months and had a recurrence; of these, 1 had a live birth.ConclusionLNG‐IUD is effective for the management of AEH and EC in young patients who desire fertility‐sparing treatment, including those ineligible for MPA owing to the presence of comorbidities and those with recurrence after MPA treatment (6‐month treatment), and patients seeking conservative treatment without fertility preservation.
Psychobiographical trends: Untold stories and international voices in the context of social change
Authors: Mayer Claude‐Hélène 
Published: August 2022

AbstractObjectiveThis article describes the increase of publications in the area of psychobiography, thereby analysing the trends in the articles published in the special issue on psychobiography and social agency and activism. It further highlights the specific approaches taken by autobiographers who write psychobiographical accounts of extraordinary individuals and “everyday heroes” in their attempt of creating social impact in specific socio‐cultural groups, societies or even on a global level.MethodThis is a conceptional article which comments on the trends presented in this special issue.ResultsThis article presents a discussion of the special issue and its impact.ConclusionsNew trends in psychobiography are discussed and show the way forward for psychobiography.
‘For the most part it works’: Exploring how authors navigate peer review feedback
Authors: Watling Christopher , Shaw Jennifer , Field Emily , Ginsburg Shiphra 
Published: August 2022

AbstractBackgroundPeer review aims to provide meaningful feedback to research authors so that they may improve their work, and yet it constitutes a particularly challenging context for the exchange of feedback. We explore how research authors navigate the process of interpreting and responding to peer review feedback, in order to elaborate how feedback functions when some of the conditions thought to be necessary for it to be effective are not met.MethodsUsing constructivist grounded theory methodology, we interviewed 17 recently published health professions education researchers about their experiences with the peer review process. Data collection and analysis were concurrent and iterative. We used constant comparison to identify themes and to develop a conceptual model of how feedback functions in this setting.ResultsAlthough participants expressed faith in peer review, they acknowledged that the process was emotionally trying and raised concerns about its consistency and credibility. These potential threats were mitigated by factors including time, team support, experience and the exercise of autonomy. Additionally, the perceived engagement of reviewers and the cultural norms and expectations surrounding the process strengthened authors' willingness and capacity to respond productively. Our analysis suggests a model of feedback within which its perceived usefulness turns on the balance of threats and countermeasures.ConclusionsFeedback is a balancing act. Although threats to the productive uptake of peer review feedback abound, these threats may be neutralised by a range of countermeasures. Among these, opportunities for autonomy and cultural normalisation of both the professional responsibility to engage with feedback and the challenge of doing so may be especially influential and may have implications beyond the peer review setting.
Rolling‐horizon–based strategy of fully cooperative traffic under signalized intersections
Authors: Yao Yifan , Zhou Yang , Xia Jingxin , Wang Xin , Li Xiaotian , Ran Bin 
Published: August 2022

AbstractDedicated left‐turn lanes are traditionally used at intersections. This practice may not be optimal where heavy traffic exists from multiple directions. As is well known, the capacity can be increased if vehicles are grouped in the same direction in advance, but the additional infrastructure is usually needed, such as presignal systems. Fortunately, under the development of connected and automated vehicle (CAV) technology, the presignal system can be achieved by coordinating vehicles directly. To this end, we establish a modeling framework and management strategies for pure CAV traffic to achieve direction‐based grouping. A rolling time‐horizon–based sorting strategy is developed to achieve real‐time coordination under uncertain vehicle arrivals. A series of numerical experiments have shown that the improvement of the proposed sorting strategy is significant and robust compared with traditional dedicated left‐turn lane intersections without coordination, especially when the traffic is busy.
Pragmatism and Theology: Between Hasdai Crescas and Charles Peirce
Authors: Ochs Peter 
Published: August 2022

AbstractThe noted Jewish scholar Harry Wolfson (d. 1929) claimed in youthful writings that the fifteenth‐century rabbinic thinker and physicist, Hasdai Crescas, was a pragmatist. This essay introduces evidence that there are, indeed, significant analogies between elements of Hasdai Crescas’s critique of Aristotle and elements of Charles Peirce’s pragmatism. The essay concludes that Crescas’s primary work, Light of the Lord (Or Hashem), displays a unique analogue to classical American pragmatism, which analogue I label “rabbinic pragmatism” and classify as a subtype of “Jewish pragmatism.” The essay’s central hypothesis is that Crescas’s scientific reasoning is correlative to his Torah‐based reasoning. A second hypothesis is that the enabling conditions of this correlativity are the inquirer’s relation to God as author of Creation and of the Commandments (mitzvah). I argue that Crescas’s non‐finite mathematics (a potential source for Galileo) is correlative to his account of the non‐finite meanings of each Commandment so that each command displays fresh meanings in each new context of life.
Measuring the global research landscape on nonviolence (Ahiṃsā) over three decades (1991–2021)
Authors: Tyagi Sunil , Jain Lipi 
Published: August 2022

AbstractThis study employs bibliometric methods to measure the productivity of authors, organizations, and countries engaged in research on nonviolence according to preferred channels for dissemination, composition of collaborative teams, and overall research performance based on data drawn from the Elsevier Scopus database. The researchers identify three major developmental stages of nonviolence research over the course of three decades (1991–2021) and found that annual research productivity in nonviolence research has grown at a slow pace in stage 1 (1991–2000), at a moderate pace in stage 2 (2001–2010), and at a fast pace in stage 3 (2011–2021). Based on the keyword frequency and their co‐occurrence relationships, three major topical theme clusters emerged; the first theme cluster relates to religion and spirituality, the second theme cluster relates to nonviolence, peace, and conflict, and the third theme cluster relates to political tactics, law, and social movements. Authorship patterns in nonviolence research show a single authorship trend as most of the publications have been published by single authors (71.57%).