bluuebunny/crossref_metadata_2025_split huggingface dataset:
Application of internet of things in healthcare domain
Authors: Almotairi Khaled H. 
Published: December 2022

AbstractInternet of things (IoT) enables machine-to-machine, human-to-human and machine-to-human interaction. Recent advancement in IoT systems has positively impacted the daily activities of humans, from accessing information to the delivery of service in real-time. This has improved healthcare management and services, especially in medical hospitals, for effective and timely access to diagnostic information and treatment of patients. Several existing research mainly focused on the design of IoT architecture, its challenges, and benefits to human society with minor or without considering applying IoT in the healthcare domain. To bridge this gap, this study investigates the implications of IoT integration in the healthcare management domain. It presents a detailed discussion on IoT utilization to improve the functionalities of hospital management system. It also discusses some potential emerging innovations that aids the development and application of IoT in hospital management systems. Investigations show that healthcare personnel can administer treatments to patients anytime–anywhere. Patients, especially the elderly are administered treatment, as well as monitoring their wellbeing while at home with the support of wearable sensor devices. Also, some of the challenges that impedes the integration of IoT application into healthcare domain includes generation of irrelevant huge amount of data, issues of security and privacy of patient information and high cost of IoT adoption. Furthermore, the future research trends in adoption of IoT to improve healthcare domain includes stroke and epileptic seizure predictions and prosthetic sensors which is used to retrieve relevant data or information to aid the treatment of a patient in real-time.
Analytical Structure and Performance of Interval Type-2 Fuzzy Two-Term Controllers with Varying Footprint of Uncertainty
Authors: Raj Ritu , Yang Jung-Min 
Published: December 2022

AbstractWhile type-2 fuzzy control has gained a lot of attention in the recent years, several challenges still remain with respect to controller design. The footprint of uncertainty (FoU) plays a very important role in designing type-2 fuzzy controllers, since the performance of type-2 fuzzy controllers largely depends on the choice of FoU. In this paper, we propose a simplified model of interval type-2 (IT2) fuzzy two-term controllers of Takagi–Sugeno (TS) type with only two rules in the rule base. The controller model is derived with varying FoUs based on only two type-2 input fuzzy sets (the simplest case). An extension to multiple input fuzzy sets is also presented. We investigate the variation in control surface and computational aspects of the IT2 fuzzy two-term controller as the FoU is varied. The performance of the proposed IT2 fuzzy controller with respect to varying FoUs is evaluated in the simulation study.
Machine Learning Modeling of Protein-Intrinsic Features Predicts Tractability of Targeted Protein Degradation
Authors: Zhang Wubing , Roy Burman Shourya S. , Chen Jiaye , Donovan Katherine A. , Cao Yang , Shu Chelsea , Zhang Boning , Zeng Zexian , Gu Shengqing , Zhang Yi , Li Dian , Fischer Eric S. , Tokheim Collin , Shirley Liu X. 
Published: December 2022

Abstract
Targeted protein degradation (TPD) has rapidly emerged as a therapeutic modality to eliminate previously undruggable proteins by repurposing the cell’s endogenous protein degradation machinery. However, the susceptibility of proteins for targeting by TPD approaches, termed “degradability”, is largely unknown. Here, we developed a machine learning model, model-free analysis of protein degradability (MAPD), to predict degradability from features intrinsic to protein targets. MAPD shows accurate performance in predicting kinases that are degradable by TPD compounds [with an area under the precision–recall curve (AUPRC) of 0.759 and an area under the receiver operating characteristic curve (AUROC) of 0.775] and is likely generalizable to independent non-kinase proteins. We found five features with statistical significance to achieve optimal prediction, with ubiquitination potential being the most predictive. By structural modeling, we found that E2-accessible ubiquitination sites, but not lysine residues in general, are particularly associated with kinase degradability. Finally, we extended MAPD predictions to the entire proteome to find 964 disease-causing proteins (including proteins encoded by 278 cancer genes) that may be tractable to TPD drug development.
Increased serum cotinine and obesity negatively impact asthma exacerbations and hospitalizations: A cross-sectional analysis of NHANES
Authors: Greiner Benjamin , Elenwo Covenant , Hartwell Micah 
Published: December 2022

AbstractBackground:Asthma is the most common non-communicable chronic airway disease worldwide. Obesity and cigarette use independently increase asthma morbidity and mortality. Current literature suggests that obesity and smoking synergistically increase asthma-related wheezing.Objective:To assess whether increased serum cotinine and obesity act synergistically to increase the likelihood of having an asthma exacerbation, emergency department (ED) visit, or hospitalization.Methods:A cross-sectional analysis of the 2011–2015 iterations of NHANES database was performed. Patients aged 18 years or greater with asthma were included. Serum cotinine was utilized as an accurate measurement of cigarette use. Logistic regression models were constructed to determine whether elevated serum cotinine and obesity were associated with self-reported asthma exacerbations, asthma-specific ED usage, and hospitalizations for any reason in the past year. Odds ratios were adjusted for age, gender, race, and ethnicity. Interactions were assessed by multiplying the adjusted effect sizes for elevated cotinine and obesity.Results:We identified 2179 (N= 32,839,290) patients with asthma, of which 32.2% were active smokers and 42.7% were obese. Patients with an elevated cotinine and asthma were significantly more likely to have had an asthma-related ED visit in the past year (adjusted odds ratio [AOR] 1.82; 95% CI 1.19–2.79), have a physician-prescribed asthma medication (AOR 2.04; 95% CI 1.11–3.74), and have a hospitalization for any reason (AOR 3.65; 95% CI 1.88–7.07) compared to those with low cotinine. Patients with asthma and obesity were more likely to have an asthma-related ED visit (AOR 1.67; 95% CI 1.06–2.62) or hospitalization for any reason in the past year compared to non-obese patients (AOR 2.76; 95% CI 1.69–4.5). However, a statistically significant interaction between obesity and cotinine was only identified in patients who currently have asthma compared to a previous asthma diagnosis (AOR 1.76; 95% CI 1.10–2.82). There were no synergistic interactions among ED usage or asthma exacerbations.Conclusion:Nearly one-third of patients with asthma were current smokers, and almost half were obese. This study identified elevated serum cotinine, a metabolite of cigarette use, and obesity as key risk factors for asthma exacerbations, asthma-related ED visits, and hospitalizations for any reason. Elevated serum cotinine and obesity were not found to act synergistically in increasing asthma exacerbations or ED visits. However, the presence of both risk factors increased the risk of currently having asthma (compared to a previous diagnosis) by 76%. Serum cotinine may be useful in predicting asthma outcomes.
Effect of the COVID-19 Pandemic on Musculoskeletal Care in the Emergency Room
Authors: Frontera Walter R. , Latimer Marcos R. , de Jesús Kevin , Pabón Angel , González Juan , Conde José G. 
Published: December 2022

Abstract

Objective:
Study the effect of the coronavirus disease (COVID-19) pandemic on emergency room (ER) utilization for musculoskeletal (MSK) complaints.

Methods:
Data from ER encounters in a teaching hospital for years 2019 and 2020 were extracted from an electronic database. The ICD-10-CM codes were used to assign the primary diagnosis. Joinpoint regression was applied to a time-series to detect changes in daily encounters (all-cause and MSK). Total number and median daily encounters were calculated by year, sex, age groups, and diagnostic codes for each year.

Results:
Overlapping intervals within March 2020 showed drops of 8.1 all-cause encounters per day (95% CI: 4.8-11.5), and 1.2 MSK encounters per day (95% CI: 0.8-1.7), resulting in net losses for the year of 33.2% for all-cause and 35.8% for MSK encounters. Reductions were observed for both sexes and all age groups. MSK codes with largest declines were low back pain, joint pain, and limb pain.

Conclusion:
The COVID-19 pandemic resulted in major reductions in all-cause and MSK encounters in the ER of an academic hospital probably due to governmental restrictions and a change in patients behaviors. Persistence of the observed reduction suggests that patients requiring ER services delayed seeking care for MSK and other health conditions.
Unsupervised domain adaptation for Global Precipitation Measurement satellite constellation using Cycle Generative Adversarial Nets
Authors: Sambath Vibolroth , Viltard Nicolas , Barthès Laurent , Martini Audrey , Mallet Cécile 
Published: December 2022

AbstractArtificial intelligence has provided many breakthroughs in the field of computer vision. The fully convolutional networks U-Net in particular have provided very promising results in the problem of retrieving rain rates from space-borne observations, a challenge that has persisted over the past few decades. The rain intensity is estimated from the measurement of the brightness temperatures on different microwave channels. However, these channels are slightly different depending on the satellite. In the case where a retrieval model has been developed from a single satellite, it may be advantageous to use domain adaptation methods in order to make this model compatible with all the satellites of the constellation. In this proposed feasibility study, a Cycle Generative Adversarial Nets model is used for adapting one set of brightness temperature channels to another set. Results of a toy experiment show that this method is able to provide qualitatively good precipitation structure but still could be improved in terms of precision.
“An Offence New in Its Kind”: Responses to Assassination Attempts on British Royalty, 1800–1900
Authors: Pentland Gordon 
Published: December 2022

AbstractAttempted assassinations have only rarely been given sustained and systematic attention by historians. This article focuses on a series of attempts to assassinate members of the British royal family across the nineteenth century. In exploring the responses of political elites and wider publics to these attacks, the author argues for the development of a robust and enduring script with which to navigate physical attacks on the sovereign and his or her family. Overall, this script tended to support the monarchy by articulating visions of the proper relationship between crown and people and contrasting these with political regimes in Europe and elsewhere. It also, however, served to highlight some of the key tensions within a modernizing institution between accessibility and publicity on the one hand and security on the other.
Needmorella, a new trilobite genus of the Synphoriinae (Dalmanitidae) from the Lower–Middle Devonian of West Virginia
Authors: Holloway David J. , Scott Brian M. 
Published: December 2022

AbstractThe trilobite Needmorella new genus, with type species N. simoni new genus new species from the late Emsian to mid-Eifelian Needmore Shale of West Virginia, is a distinctive member of the subfamily Synphoriinae. It also occurs in the same formation in Pennsylvania and Virginia. It is not very similar to other Devonian representatives of the subfamily and is considered to have its origins in a morphologically less-derived ancestor because it shares certain similarities with Silurian genera, including the very short anterior cephalic border unmodified by crenulations or spines, S2 that is not largely reduced to a deep pit adaxially, the relatively low inflation of L3, and the well-defined interpleural furrows on the pygidium. Other particularly distinctive characters of the genus include the very long genal spines and the abaxially inflated and expanded posterior pleural bands on the thorax and pygidium that project slightly distally. The conventional concept of the Devonian synphoriine Anchiopsis Delo, 1935 appears to be incompatible with the holotype of the type species, judging from the early illustrations of the specimen, and the genus could be a synonym of Synphoria Clarke, 1894.UUID: http://zoobank.org/4a820e27-54ec-4f7b-a408-675e62b75154
ESTABLISHING AN ABSOLUTE CHRONOLOGICAL FRAMEWORK FOR THE LATE CHALCOLITHIC TO EARLY BRONZE AGE IN IRAQI KURDISTAN: RADIOCARBON DATES FROM KANI SHAIE
Authors: Renette S , Lewis M P , Wencel M M , Farahani A , Tomé A 
Published: December 2022

ABSTRACTThe possibility to conduct new fieldwork projects in previously largely unexplored Iraqi Kurdistan during the past decade has reinvigorated research into the transformative fifth to third millennium BCE (Chalcolithic to Early Bronze Age) in southwest Asia when human societies grew from small, autonomous villages to centralized states with urban centers. Major efforts to synchronize stratigraphic sequences from various sites in order to reach a consensus on archaeological periodization and to identify the absolute chronology of societal transformations necessarily focused on available datasets from Syria, Turkey, and Iran. However, increased understanding of differences in communities’ adoption, adaptation, or rejection of new forms of technologies and social organization demands the need for constructing region-specific absolute chronological models for comparative analysis. Such work is particularly challenging in the case of Iraqi Kurdistan where sites frequently have major hiatuses in occupation. The site of Kani Shaie (Sulaymaniyah Governorate) offers the rare opportunity to investigate the Chalcolithic to Early Bronze Age with a largely uninterrupted sequence of occupation from ca. 5500 to 2500 BCE. This paper presents a series of fourteen radiocarbon dates, representing every archaeological period in this timeframe, as a first step toward the construction of a regional absolute chronology.
PERFORMANCE AND INTER-COMPARISON TESTS OF THE MICADAS AT THE RADIOCARBON LABORATORY OF LANZHOU UNIVERSITY, CHINA
Authors: Cao Huihui , Wang Zongli , He Jianhua , Guo Jiale , Jull A J Timothy , Zhou Aifeng , Dong Guanghui , Chen Fahu 
Published: December 2022

ABSTRACTSince 2018, the radiocarbon laboratory of Lanzhou University has been equipped with a compact accelerator mass spectrometer—a 200-KV mini carbon dating system (MICADAS), together with an auto graphitization equipment (AGE III). The laboratory has for a long time prepared graphite targets for 14C dating of plant fossils, charcoal, bones, and bulk organic matter. Herein, we give an overview of the operating status and performance of the dating facility. The long-term measurements of the standard and blank samples indicated that the results for MICADAS in Lanzhou University were accurate and stable and of high sensitivity. Fifteen sets of organic materials collected from archaeological sites in northwest China were selected for an inter-comparison study involving the participation of four specialist laboratories. The 14C dating results for the homogenized archaeological samples from several of the laboratories showed a high degree of consensus. The long-term performance and inter-comparison data for MICADAS confirmed that the radiocarbon laboratory of Lanzhou University could provide stable and accurate 14C dating results. In this context, the 14C dating results for a number of key archaeological/environmental samples were validated.
STUDY OF BIO-BASED CARBON FRACTIONS IN TIRES AND THEIR PYROLYSIS PRODUCTS
Authors: Gill Komal Aziz , Michczyńska Danuta J , Michczyński Adam , Piotrowska Natalia , Kłusek Marzena , Końska Klaudia , Wróblewski Krzysztof , Nadeau Marie-Josée , Seiler Martin 
Published: December 2022

ABSTRACTWasted tires are the great source of fuel and valuable components but could be a cause of environmental and land pollution. This study shows the detailed method for the determination of radiocarbon isotope (14C) concentration in tires and their pyrolysis products. Samples are taken from truck and passenger car tires in the form of shredded rubber, pyrolysis oil and recovered carbon black. Liquid scintillation counting (LSC) and accelerator mass spectrometry (AMS) techniques were used for the investigation at Gliwice Radiocarbon and Mass Spectrometry Laboratory, and National Laboratory for Age Determination, Trondheim, Norway. The results are in good agreement. Radiocarbon concentration of the rubber varies significantly because of its complex structure and composition within the tires. The 14C concentration values were found to be higher in pyrolytic oil compared to rubber, and greater in truck tires rather than car tires.
The Language of Imperial Cult and Roman Religion in the Latin New Testament: The Latin Renderings of ‘Saviour’
Authors: Persig Anna 
Published: December 2022

AbstractThe title σωτήρ, ‘saviour’, is bestowed on Christ and God in the New Testament and rendered in the Latin translations by conseruator, saluificator, salutificator, salutaris and saluator. Although these terms convey the same meaning, they are not interchangeable: this study argues that conseruator, which is the most frequent word for saviour on imperial coins, is rarely attested in the Latin versions because of its association with the imperial cult. The predominant translation, saluator, was coined as an alternative rendering to the other words which had religious and political connotations.
Combined (dual) drug therapy for the treatment of patent ductus arteriosus: last approach prior to ligation
Authors: Deveci Mehmet F. , Kaya Huseyin , Yurttutan Sadik , Alagoz Meral , Gokce Ismail K. , Karakurt Cemsit , Gullu Ufuk U. , Oncul Mehmet , Ozdemir Ramazan 
Published: December 2022

AbstractObjective:We aimed to evaluate the efficacy of combined (ibuprofen+paracetamol) medical therapy in cases of persistent haemodynamically significant patent ductus arteriosus that are resistant to standard medical monotherapy (ibuprofen and/or paracetamol) in this retrospective multi-centre study.Methods:The combined therapy included the administration of 15mg/kg/dose of paracetamol every 6 h for 3 days and ibuprofen at an initial dose of 10mg/kg/dose followed by 5 mg/kg/dose every 24 h. After 2 days following the administration of the last dose, the researchers evaluated the efficacy of combined treatment by conducting an echocardiographic examination.Results:Of all 42 patients who received combined therapy, 37 (88.1%) patients exhibited closure of the haemodynamically significant patent ductus arteriosus without requiring surgical ligation. Patients who did not respond to combined therapy had a higher mean birth weight and gestational age compared to those who responded (p < 0.05).Conclusion:The researchers believe the success of ibuprofen and paracetamol in haemodynamically significant patent ductus arteriosus treatment may be due to their synergistic efficacy and inhibition of the prostaglandin synthesis pathway through different enzymes. The results of our retrospective trial suggest that combination therapy with paracetamol and ibuprofen can be attempted when monotherapy is unsuccessful in treating haemodynamically significant patent ductus arteriosus, especially in centres without a surgical department.
Determinants of quality of life among Omani family caregivers of adult patients with cancer pain
Authors: Muliira Joshua K. , Kizza Irene B. , Al-Kindi Sumaiya N. 
Published: December 2022

AbstractObjectivesThe study aimed to explore the determinants of quality of life (QoL) among Omani family caregivers (FCGs) of adult patients with cancer pain.MethodsA descriptive cross-sectional design, measures of caregiver reaction, knowledge about cancer pain, self-efficacy for cancer pain and other symptom management, QoL, and patient functional status were used to collect data from 165 FCGs and patients. Descriptive, correlation, and regression analyses were performed.ResultsMost patients had intermittent (83%) and severe (50.9%) cancer pain. The FCGs had low QoL (58.44 ± 17.95), and this mostly impacted support and positive adaptation (55.2%). Low QoL was associated with low self-rated health, low confidence in the ability to control the patient’s pain, low self-efficacy, high perceived distress due to patient pain, and a high impact of caregiving on physical health. The level of caregiver distress due to the patient’s pain (p < 0.01), patient’s functional status (p < 0.01), and perceived impact of caregiving on health (p < 0.05) were significant predictors of overall QoL.ConclusionOmani FCGs of patients with cancer pain suffer a negative impact on their QoL, and this is related to the patient’s level of pain and functional status, caregiver’s health, and self-efficacy in cancer pain and symptom management. The FCGs’ QoL may be enhanced by augmenting their skills and self-efficacy in cancer pain and symptom management and by health promotion programs.
FDTD-based SAR calculation of a wearable antenna for wireless body area network devices
Authors: Savcı Hüseyin Şerif , Kaburcuk Fatih 
Published: December 2022

AbstractWireless-connected wearable electronics are finding extensive usage for diagnostic and therapeutic purposes after the globally spread pandemic disease of COVID-19. Although they are undoubtedly helpful for keeping physical distance, their health effects are still under investigation from different aspects and are still a concern for the end-users. In this study, a custom M-shaped wearable antenna covering the wireless body area network and wireless local area network frequencies is designed, built, and measured. A beret cap made from a 2 mm thick textile is used as a substrate. The specific absorption rate (SAR) in a realistic human-head model due to electromagnetic energy produced by the antenna is evaluated using the finite-difference time-domain method. The SAR distributions for 1-g and 10-g tissues are calculated at 2.4 and 5.8 GHz. It is shown that the obtained maximum SAR values for 1-g and 10-g tissues at each frequency of interest were less than the limits determined by IEEE RF exposure guidelines and standards.
Changes in Antarctic Ice Sheet Motion Derived From Satellite Radar Interferometry Between 1995 and 2022
Authors: Rignot Eric , Mouginot Jeremie , Scheuchl Bernd , Jeong Seongsu 
Published: December 2022

AbstractIce motion and boundaries are critical information for ice sheet models that project ice evolution in a warming climate. We present four historical, continent‐wide, maps of Antarctic‐wide ice motion and boundaries for the time period 1995–2022. The results reveal no change in the interior region of East Antarctica, iceberg detachments at ice shelf fronts, and widespread glacier speedup that propagates 100 km's inland in West Antarctica and the Antarctic Peninsula. Speedup affects the entire drainage of the Amundsen Sea Embayment sector; the entire west coast of the Antarctic Peninsula down to GeorgeVI Ice Shelf; the east coast down to Larsen C Ice Shelf; Getz Ice Shelf, Hull and Land glaciers in West Antarctica; Matusevitch, Ninnis, Mertz and Denman glaciers, glaciers in Porpoise and Vincennes Bay; and Robert, Wilma and Rayner glaciers in Enderby Land, in East Antarctica. We attribute the observed glacier changes to increased melting by warmer ocean waters.