bluuebunny/crossref_metadata_2025_split huggingface dataset:
Revision of Faraday rotation measure constraints on the primordial magnetic field using the IllustrisTNG simulation
Authors: Arámburo-García Andrés , Bondarenko Kyrylo , Boyarsky Alexey , Neronov Andrii , Scaife Anna , Sokolenko Anastasia 
Published: July 2022

ABSTRACT
Previously derived Faraday rotation constraints on the volume-filling intergalactic magnetic field (IGMF) have used analytical models that made a range of simplifying assumptions about magnetic field evolution in the intergalactic medium and did not consider the effect of baryonic feedback on large-scale structures. In this work, we revise existing Faraday rotation constraints on the IGMF using a numerical model of the intergalactic medium from the IllustrisTNG cosmological simulation that includes a sophisticated model of the baryonic feedback. We use the IllustrisTNG model to calculate the rotation measure and compare the resulting mean and median of the absolute value of the rotation measure with data from the NRAO VLA Sky Survey (NVSS). The numerical model of the intergalactic medium includes a full magnetohydrodynamic model of the compressed primordial magnetic field as well as a model of the regions where the magnetic field is not primordial, but is rather produced by the process of baryonic feedback. Separating these two types of regions, we are able to assess the influence of the primordial magnetic field on the Faraday rotation signal. We find that by correcting for regions of compressed primordial field and accounting for the fact that part of the intergalactic medium is occupied by magnetic fields spread by baryonic feedback processes rather than by the primordial field relaxes the Faraday rotation bound by a factor of ≃3. This results in B0 &lt; 1.8 × 10−9 G for large correlation length IGMFs.
On the asymptotic behaviour of cosmic density-fluctuation power spectra of cold dark matter
Authors: Konrad Sara , Ginat Yonadav Barry , Bartelmann Matthias 
Published: July 2022

ABSTRACTWe study the small-scale asymptotic behaviour of the cold dark matter density fluctuation power spectrum in the Zel’dovich approximation, without introducing an ultraviolet cut-off. Assuming an initially correlated Gaussian random field and spectral index 0 &lt; ns &lt; 1, we derive the small-scale asymptotic behaviour of the initial momentum–momentum correlations. This result is then used to derive the asymptotics of the power spectrum in the Zel’dovich approximation. Our main result is an asymptotic series, dominated by a k−3 tail at large wave-numbers, containing higher-order terms that differ by integer powers of $k^{n_\mathrm{ s}-1}$ and logarithms of k. Furthermore, we show that dark matter power spectra with an ultraviolet cut-off develop an intermediate range of scales where the power spectrum is accurately described by the asymptotics of dark matter without a cut-off. These results reveal information about the mathematical structure that underlies the perturbative terms in kinetic field theory and thus the non-linear power spectrum. We also discuss the sensitivity of the small-scale asymptotics to the spectral index ns.
Effects of Domestication on Plant–Microbiome Interactions
Authors: Gutierrez Andres , Grillo Michael A 
Published: July 2022

Abstract
Through the process of domestication, selection is targeted on a limited number of plant traits that are typically associated with yield. As an unintended consequence, domesticated plants often perform poorly compared to their wild progenitors for a multitude of traits that were not under selection during domestication, including abiotic and biotic stress tolerance. Over the past decade, advances in sequencing technology have allowed for the rigorous characterization of host-associated microbial communities, termed the microbiome. It is now clear that nearly every conceivable plant interaction with the environment is mediated by interactions with the microbiome. For this reason, plant–microbiome interactions are an area of great promise for plant breeding and crop improvement. Here, we review the literature to assess the potential impact that domestication has had on plant–microbiome interactions and the current understanding of the genetic basis of microbiome variation to inform plant breeding efforts. Overall, we find limited evidence that domestication impacts the diversity of microbiomes, but domestication is often associated with shifts in the abundance and composition of microbial communities, including taxa of known functional significance. Moreover, genome-wide association studies and mutant analysis have not revealed a consistent set of core candidate genes or genetic pathways that confer variation in microbiomes across systems. However, such studies do implicate a consistent role for plant immunity, root traits, root and leaf exudates and cell wall integrity as key traits that control microbiome colonization and assembly. Therefore, selection on these key traits may pose the most immediate promise for enhancing plant–microbiome interactions through breeding.
Genome Analysis Revives a Forgotten Hybrid Crop Edo-dokoro in the Genus Dioscorea
Authors: Natsume Satoshi , Sugihara Yu , Kudoh Aoi , Oikawa Kaori , Shimizu Motoki , Ishikawa Yuko , Nishihara Masahiro , Abe Akira , Innan Hideki , Terauchi Ryohei 
Published: July 2022

Abstract
A rhizomatous Dioscorea crop ‘Edo-dokoro’ was described in old records of Japan, but its botanical identity has not been characterized. We found that Edo-dokoro is still produced by four farmers in Tohoku-machi of the Aomori prefecture, Japan. The rhizomes of Edo-dokoro are a delicacy to the local people and are sold in the markets. Morphological characters of Edo-dokoro suggest its hybrid origin between the two species, Dioscorea tokoro and Dioscorea tenuipes. Genome analysis revealed that Edo-dokoro likely originated by hybridization of a male D. tokoro to a female D. tenuipes, followed by a backcross with a male plant of D. tokoro. Edo-dokoro is a typical minor crop possibly maintained for more than 300 years but now almost forgotten by the public. We hypothesize that there are many such uncharacterized genetic heritages passed over generations by small-scale farmers that await serious scientific investigation for future use and improvement by using modern genomics information.
Risking or Derisking: How Management Fees Affect Hedge Fund Risk-Taking Choices
Authors: Yin Chengdong , Zhang Xiaoyan 
Published: July 2022

AbstractHedge fund managers’ risk-taking choices are influenced by their compensation structure. We differ from most studies that focus on incentive fees and the high-water mark by examining how management fees affect managers’ risk-taking. Our simple model shows that managers’ risk-taking is negatively related to their future management fees. Using fund-level data, we find that future management fees are the dominant component of managers’ total compensation. When the contribution of future management fees increases, managers reduce risk-taking to increase survival probabilities. Moreover, funds with higher decreasing returns to scale are more sensitive to future management fees and reduce risk-taking even more.Authors have furnished an Internet Appendix, which is available on the Oxford University Press Web site next to the link to the final published paper online.
COVID-19 vaccine affects neither prothrombotic antibody profile nor thrombosis in primary anti-phospholipid syndrome: a prospective study
Authors: Pan Haoyu , Tang Zihan , Teng Jialin , Sun Yue , Liu Honglei , Cheng Xiaobing , Su Yutong , Ye Junna , Hu Qiongyi , Chi Huihui , Zhou Zhuochao , Jia Jinchao , Meng Jianfen , Wang Mengyan , Wang Fan , Chen Xia , Ma Yuning , Zhang Hao , You Yijun , Zhu Dehao , Chen Longfang , Yang Chengde , Shi Hui , Liu Tingting 
Published: July 2022

Abstract

Objective
To explore whether inactivated coronavirus disease 2019 vaccine influences the profile of prothrombotic autoantibodies and induces thrombotic events in primary APS patients.

Methods
We enrolled 39 primary APS patients who received two doses of inactivated severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine (BBIBPCorV, Sinopharm, Beijing, China) voluntarily in this prospective cohort. Prothrombotic autoantibodies were determined before vaccination and 4 weeks after the second dose of vaccination. Thrombotic disorders were evaluated via hospital site visits and assessments.

Results
There was no significant difference in the presence of all 11 autoantibodies detected before and 4 weeks after vaccination: for aCL, IgG (14 vs 16, P = 0.64), IgM (13 vs 19, P = 0.34), IgA (2 vs 3, P = 0.64); anti-β2GP1, IgG (12 vs 12, P = 1.00), IgM (5 vs 8, P = 0.36), IgA (4 vs 3, P = 0.69); anti-PS/PT IgG (13 vs 16, P = 0.48), IgM (17 vs 22, P = 0.26); LAC (22 vs 28, P = 0.16); aPF4-heparin (0 vs 0, P = 1.00) and ANA (23 vs 26, P = 0.48). Notably, the distribution of the aPL profile in the pre- and post-vaccination cohorts was not affected by SARS-CoV-2 vaccination: for patients with a low-risk aPL profile (11 vs 10, P = 0.799) and patients with a high-risk aPL profile (28 vs 29, P = 0.799), respectively. Furthermore, no case exhibited symptoms of the thrombotic disorder during a minimum follow-up period of 12 weeks. There was no adjustment to the ongoing treatment regimens following SARS-CoV-2 vaccination.

Conclusion
Inactivated SARS-CoV-2 vaccine does not influence the profile of anti-phospholipid antibodies and anti-PF4-heparin antibodies nor induces thrombotic events in primary APS patients.
Sicca syndrome in systemic sclerosis: a narrative review on a neglected issue
Authors: Zimmermann François , Robin François , Caillault Leila , Cazalets Claire , Llamas-Gutierrez Francisco , Garlantézec Ronan , Jousse-Joulin Sandrine , Diot Elisabeth , Mensi Sami Eric , Belhomme Nicolas , Jégo Patrick , Coiffier Guillaume , Lescoat Alain 
Published: July 2022

Abstract
SSc is an auto-immune disease characterized by life-threatening manifestations such as lung fibrosis or pulmonary arterial hypertension. Symptoms with a detrimental impact on quality of life are also reported and sicca syndrome (xerostomia, xeropthalmia) is present in up to 80% of patients with SSc. Sicca syndrome can occur in the absence of overlap with Sjögren’s disease and recent studies highlight that fibrosis of minor and major salivary glands, directly linked to the pathogenesis of SSc, could be a major contributor of xerostomia in SSc. This narrative review provides an overview of the clinical presentation, diagnostic strategies, management and future perspectives on sicca syndrome in patients with SSc.
Comparison of Healthcare Utilization Between Telemedicine and Standard Care: A Propensity-Score Matched Cohort Study Among Individuals With Chronic Psychotic Disorders in Ontario, Canada
Authors: Shakeri Ahmad , Chu Cherry , Stamenova Vess , Fang Jiming , Barker Lucy C , Vigod Simone N , Bhatia R Sacha , Tadrous Mina 
Published: July 2022

Abstract

Background
Telemedicine adoption has grown significantly due to the coronavirus of 2019 pandemic; however, it remains unclear what the impact of widespread telemedicine use is on healthcare utilization among individuals with psychosis.

Objectives
To investigate the impact of telemedicine use on changes in healthcare utilization among patients with chronic psychotic disorders (CPDs).

Study Design
We conducted a population-based, retrospective propensity-matched cohort study using healthcare administrative data in Ontario, Canada. Patients were included if they had at least one ambulatory visit between March 14, 2020 and September 30, 2020 and a CPD diagnosis any time before March 14, 2020. Telemedicine users (2+ virtual visits after March 14, 2020) were propensity score-matched 1:1 with standard care users (minimum of 1 in-person or virtual ambulatory visit and maximum of 1 virtual visit after March 14, 2020) based on several baseline characteristics. Monthly use of various healthcare services was compared between the two groups from 12 months before to 3 months after their index in-person or virtual ambulatory visit after March 14, 2020 using generalized estimating equations (eg, hospitalizations, emergency department [ED] visits, and outpatient physician visits). The slope of change over the study period (ie, rate ratio) as well as a ratio of slopes, were calculated for both telemedicine and standard care groups for each outcome.

Study Results
A total of 18 333 pairs of telemedicine and standard care patients were identified after matching (60.8% male, mean [SD] age 45.4 [16.3] years). There was a significantly greater decline across time in the telemedicine group compared to the standard care group for ED visits due to any psychiatric conditions (ratio of slopes for telemedicine vs standard care (95% CI), 0.98 (0.98 to 0.99)). However, declines in primary care visit rates (ratio of slopes for telemedicine vs standard care (1.01 (1.01 to 1.02)), mental health outpatient visits with primary care (1.03 (1.03 to 1.04)), and all-cause outpatient visits with primary care (1.01 (1.01 to 1.02)), were steeper among the standard care group than telemedicine group.

Conclusions
Overall, patients with CPDs appeared to benefit from telemedicine as evidenced by increased outpatient healthcare utilization and reductions in ED visits due to psychiatric conditions. This suggests that telemedicine may have allowed this patient group to have better access and continuity of care during the initial waves of the pandemic.
The cortical N1 response to balance perturbation is associated with balance and cognitive function in different ways between older adults with and without Parkinson’s disease
Authors: Payne Aiden M , McKay J Lucas , Ting Lena H 
Published: July 2022

Abstract
Mechanisms underlying associations between balance and cognitive impairments in older adults with and without Parkinson’s disease are poorly understood. Balance disturbances evoke a cortical N1 response that is associated with both balance and cognitive abilities in unimpaired populations. We hypothesized that the N1 response reflects neural mechanisms that are shared between balance and cognitive function, and would therefore be associated with both balance and cognitive impairments in Parkinson’s disease. Although N1 responses did not differ at the group level, they showed different associations with balance and cognitive function in the Parkinson’s disease vs. control groups. In the control group, higher N1 amplitudes were correlated with lower cognitive set shifting ability and lower balance confidence. However, in Parkinson’s disease, narrower N1 widths (i.e., shorter durations) were associated with greater parkinsonian motor symptom severity, lower balance ability and confidence, lower mobility, and lower overall cognitive function. Despite different relationships across populations, the present results suggest the N1 response reflects neural processes related to both balance and cognitive function. A better understanding of neural mechanisms linking balance and cognitive function could provide insight into associations between balance and cognitive decline in aging populations.
Personal space regulation is affected by unilateral temporal lesions beyond the amygdala
Authors: Dureux Audrey , Zigiotto Luca , Sarubbo Silvio , Desoche Clément , Farnè Alessandro , Bolognini Nadia , Hadj-Bouziane Fadila 
Published: July 2022

AbstractWe constantly face situations involving interactions with others that require us to automatically adjust our physical distances to avoid discomfort or anxiety. A previous case study has demonstrated that the integrity of both amygdalae is essential to regulate interpersonal distances. Despite unilateral lesion to the amygdala, as to other sectors of the medial temporal cortex, are known to also affect social behavior, their role in the regulation of interpersonal distances has never been investigated. Here, we sought to fill this gap by testing three patients with unilateral temporal lesions following surgical resections, including one patient with a lesion mainly centered on the amygdala and two with lesions to adjacent medial temporal cortex, on two versions of the stop distance paradigm (i.e. in a virtual reality environment and in a real setting). Our results showed that all three patients set shorter interpersonal distances compared to neurotypical controls. In addition, compared to controls, none of the patients adjusted such physical distances depending on facial emotional expressions, despite they preserved ability to categorize them. Finally, patients' heart rate responses differed from controls when viewing approaching faces. Our findings bring compelling evidence that unilateral lesions within the medial temporal cortex, not necessarily restricted to the amygdala, are sufficient to alter interpersonal distance, thus shedding new light on the neural circuitry regulating distance in social interactions.
Upregulation of Circ_0035266 Contributes to the Malignant Progression of Inflammation-Associated Malignant Transformed Cells Induced by Tobacco-Specific Carcinogen NNK
Authors: Hua Qiuhan , Liu Yufei , Li Meizhen , Li Xueqi , Chen Wei , Diao Qinqin , Ling Yihui , Jiang Yiguo 
Published: July 2022

Abstract
Cigarette smoking-induced chronic inflammation has been considered a vital driver of lung tumorigenesis. The compounds 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), a tobacco-specific carcinogen, and lipopolysaccharide (LPS), an inflammatory inducer, are important components of tobacco smoke which have been implicated in inflammation-driven carcinogenesis. However, the biological effects and underlying mechanisms of LPS-mediated inflammation on NNK-induced tumorigenesis are still unclear. In this study, BEAS-2B human bronchial epithelial cells were exposed to NNK, LPS or both, for short- or long-term periods. We found that acute LPS exposure promoted the secretion of granulocyte-macrophage colony stimulating factor (GM-CSF) and interleukin (IL)-6 in NNK-treated BEAS-2B cells. In addition, chronic LPS exposure facilitated the NNK-induced malignant transformation process by promoting cell proliferation, cell cycle alteration, migration, and clonal formation. Previously, we determined that circular RNA circ_0035266 enhanced cellular inflammation in response to NNK + LPS by sponging miR-181d-5p and regulating expression of its downstream target DEAD-Box Helicase 3 X-Linked (DDX3X). Here, we found that knockdown of circ_0035266 or DDX3X led to a remarkable inhibition of the proliferation, cell cycle progression, and migration of NNK + LPS-transformed BEAS-2B cells, whereas overexpression of these genes produced the opposite effects, indicating the oncogenic roles of circ_0035266 and DDX3X in the malignant progression of chronic inflammation-driven malignant transformed cells. Moreover, the regulatory relationships among circ_0035266, miR-181d-5p, and DDX3X were further confirmed using a group of lung cancer tissues. Conclusively, our findings provide novel insights into our understanding of inflammation-driven tumorigenesis using a cellular malignant transformation model, and indicate a novel tumor-promoting role for circ_0035266 in chemical carcinogenesis.
Molecular plasticity to soil water deficit differs between sessile oak (Quercus Petraea (Matt.) Liebl.) high- and low-water use efficiency genotypes
Authors: Le Provost Gregoire , Gerardin Theo , Plomion Christophe , Brendel Oliver 
Published: July 2022

Abstract
Water use efficiency (WUE) is an important adaptive trait for soil water deficit. The molecular and physiological bases of WUE regulation in crops have been studied in detail in the context of plant breeding. Knowledge for most forest tree species lags behind, despite the need to identify populations or genotypes able to cope with the longer, more intense drought periods likely to result from climate warming. We aimed to bridge this gap in knowledge for sessile oak (Quercus petraea (Matt.) Liebl.), one of the most ecologically and economically important tree species in Europe, using a factorial design including trees with contrasted phenotypic values (low and high WUE) and two watering regimes (control and drought). By monitoring the ecophysiological response, we first qualified genotypes for their WUE (by using instantaneous and long-term measures). We then performed RNA-seq to quantify gene expression for the three most extreme genotypes exposed to the two watering regimes. By analyzing the interaction term, we were able to capture the molecular strategy of each group of plants for coping with drought. We identified putative candidate genes potentially involved in the regulation of transpiration rate in high-WUE phenotypes. Regardless of water availability, trees from the high-WUE phenotypic class overexpressed genes associated with drought responses, and in the control of stomatal density and distribution, and displayed a downregulation of genes associated with early stomatal closure and high transpiration rate. Fine physiological screening of sessile oaks with contrasting WUE, and their molecular characterization (i) highlighted subtle differences in transcription between low- and high-WUE genotypes, identifying key molecular players in the genetic control of this trait and (ii) revealed the genes underlying the molecular strategy that evolved in each group to potentially cope with water deficit, providing new insight into the within-species diversity in drought adaptation strategies.
Comparison of Shoulder Motion Measurements by Visual Estimate, Goniometer and Motion Capture
Authors: Russo Stephanie A. , Chafetz Ross S. , Rodriguez Luisa M. , Roposh Carolyn M. , Zlotolow Dan A. , Kozin Scott H. , Gaughan John P. , Richards James G. 
Published: July 2022

Background:
Brachial plexus birth injuries (BPBI) can result in lasting impairments of external rotation and cross-body adduction (CBA) that disrupt functional activities such as dressing, grooming, or throwing a ball. The purpose of this study was to compare the quantification of shoulder humerothoracic (HT) external rotation (ER), and glenohumeral (GH) CBA by 3 methods – physician visual estimate, goniometer measurement by an occupational therapist, and motion capture.

Methods:
Twenty-six patients with BPBI (average age of 9.9±3.2 y) participated in this study. Mallet scores and visual estimates of passive HT ER and GH CBA were recorded by a physician. The passive measures were repeated by an occupational therapist using a goniometer while motion capture measures were simultaneously collected. Active HT ER was also measured by motion capture. The passive measures were compared with analyses of variance with repeated measures, intraclass correlations, and Bland-Altman plots. External rotation Mallet scores determined by motion capture and by the physician were compared.

Results:
The measures of GH CBA were not statistically different and demonstrated good agreement, but substantial variation. For HT ER, all measures were significantly different and demonstrated poor agreement and substantial variation. When the joint angles measured by motion capture were used to determine the Mallet score, 79% of external rotation Mallet scores assigned by the physician were incorrectly categorized, with the physician always scoring the participant higher than predicted motion capture Mallet score.

Conclusions:
Both GH CBA and HT ER measures demonstrated substantial variability between measurement types, but only HT ER joint angles were significantly different. In addition, more than three-quarters of external rotation Mallet scores were misclassified by the physician. Motion capture measurements offer the benefit of less susceptibility to patients’ compensatory and/or out-of-plane movements and should be considered for clinical assessment of shoulder range of motion in children with BPBI. If motion capture is unavailable, the use of a goniometer provides more accurate clinical measures of shoulder motion than visual estimates and care should be taken to minimize and account for compensatory movement strategies.

Level of Evidence:
Level IV Case series