bluuebunny/crossref_metadata_2025_split huggingface dataset:
Survey on computational 3D visual optical art design
Authors: Wu Kang , Fu Xiao-Ming , Chen Renjie , Liu Ligang 
Published: December 2022

AbstractVisual arts refer to art experienced primarily through vision. 3D visual optical art is one of them. Artists use their rich imagination and experience to combine light and objects to give viewers an unforgettable visual experience. However, the design process involves much trial and error; therefore, it is often very time-consuming. This has prompted many researchers to focus on proposing various algorithms to simplify the complicated design processes and help artists quickly realize the arts in their minds. To help computer graphics researchers interested in creating 3D visual optical art, we first classify and review relevant studies, then extract a general framework for solving 3D visual optical art design problems, and finally propose possible directions for future research.
Recycling of aluminum dross for producing calcinated alumina by microwave plasma
Authors: Lin Wen-Chang , Tsai Cheng-Hsien , Zhang Da-Nian , Syu Sheng-Syong , Kuo Yi-Ming 
Published: December 2022

AbstractDue to the excellent engineering property, aluminum has become an important material for processing industries. As the demand of aluminum increased, a large amount of waste aluminum dross has been generated during the aluminum smelting process. The aluminum dross contained aluminum nitride and would cause odor while being disposed in landfill, making the aluminum dross disposal a tough issue. Therefore, the aluminum dross was mostly stored in the original plants. The objective of this study is to develop an economically-feasible and environmentally-friendly technology to recover aluminum dross.In this study, the original aluminum dross was collected from the secondary smelting aluminum dross factories with 33.6% Al. The aluminum dross was dissolved with 3 M NaOH at 50 °C for 60 min to form NaAl(OH)4 solution. The NaAl(OH)4 was then transformed to aluminum hydroxide by adding H2SO4. Then, the aluminum hydroxide was filtered, washed, and dried. The thermogravimetric analysis and X-ray powder diffraction analysis result show that the main crystal phase of aluminum hydroxide (intermediate product) is boehmite. The aluminum hydroxide powder was calcined at 700 °C for 5 min by an atmospheric-pressure microwave plasma to produce Al2O3. The result show that this process can reduce environmental pollution and recycle aluminum as recoverable form.
Cognitive functions and behavioural profiles in children with cystinosis treated with cysteamine and correlation with treatment duration
Authors: Atia Fatma M. , Alfaleet Weam Ryad , Shaheen Somaya H. , Soliman Neveen A. 
Published: December 2022

Abstract
Background
Cystinosis is a rare autosomal recessive disease. Children with nephropathic cystinosis (NCTN) have evidence of intellectual dysfunction and behavioural abnormalities which are attributed to renal dysfunction, metabolic disarrangement, and gene mutation. This study aimed to characterize the cognitive functions and behavioural profiles in nephropathic cystinosis patients on cysteamine therapy, and determine its relation to cysteamine treatment duration. In this analytical cohort study, 20 children with nephropathic cystinosis aged 6 years or above were compared to 26 children with chronic kidney disease (CKD) matched in age, sex, and CKD stage. All patients were subjected to full clinical and psychometric assessment using the Child Behaviour Checklist (CBCL) and the Arabic language version of Stanford-Binet test (SB).

Results
There was no significant difference between both groups regarding Stanford-Binet test (SB) and Child Behavioural Checklist (CBCL), apart from delinquent behaviour. Duration of cysteamine treatment was inversely correlated with short-term memory, thought, and sex problems.

Conclusions
Children with cystinosis have a wide range of neurocognitive and behavioural problems that still present after cysteamine treatment and may be related to impact of genetic mutation on brain structure and function. Longer duration of cysteamine treatment could have beneficial effects on some behavioural problems.
Effective suicide prevention strategies in primary healthcare settings: a systematic review
Authors: Azizi Hosein , Esmaeili Elham Davtalab , Khodamoradi Farzad , Sarbazi Ehsan 
Published: December 2022

Abstract
Background
There is a fundamental need for health systems, health managers, and policymakers to identify effective components of suicide prevention strategies (SPS) and programs in primary healthcare (PHC) settings. Accordingly, this systematic review aimed to identify and summarize effective and significant evidence on suicide prevention in PHC setting. We systematically searched the published literature in English from PubMed, Web of Science, Scopus, CINAHL, PsychoINFO, and Embase up to 31 July 2022. The study searched all records reporting effective and significant strategies and programs on suicide prevention in PHC settings. A content analysis approach was carried out to extract major components of suicide prevention strategies in PHC settings.

Results
A total of 10 records (8 original articles and 2 reports) with 1,199,986 samples were included. In all the included articles, SPS decreased suicide rates. The majority of studies were conducted among the general population. The content analysis approach emerged five major components to SPS in PHC setting: (1) training and educating healthcare providers, (2) screening and suicide risk assessment, (3) managing depression symptoms and mental disorders, (4) managing suicide attempters and at-risk cases, and (5) prevention strategies at the general population.

Conclusions
This review provided reliable evidence for health systems to develop SPS in PHC and practitioners who are eager to provide brief and effective contact interventions for suicide risk to well-serve their patients.
Six potential biomarkers for bladder cancer: key proteins in cell-cycle division and apoptosis pathways
Authors: Inal Gültekin Güldal , Timirci Kahraman Özlem , Işbilen Murat , Durmuş Saliha , Çakir Tunahan , Yaylim İlhan , Isbir Turgay 
Published: December 2022

Abstract
Background
The bladder cancer (BC) pathology is caused by both exogenous environmental and endogenous molecular factors. Several genes have been implicated, but the molecular pathogenesis of BC and its subtypes remains debatable. The bioinformatic analysis evaluates high numbers of proteins in a single study, increasing the opportunity to identify possible biomarkers for disorders.

Methods
The aim of this study is to identify biomarkers for the identification of BC using several bioinformatic analytical tools and methods. BC and normal samples were compared for each probeset with T test in GSE13507 and GSE37817 datasets, and statistical probesets were verified with GSE52519 and E-MTAB-1940 datasets. Differential gene expression, hierarchical clustering, gene ontology enrichment analysis, and heuristic online phenotype prediction algorithm methods were utilized. Statistically significant proteins were assessed in the Human Protein Atlas database. GSE13507 (6271 probesets) and GSE37817 (3267 probesets) data were significant after the extraction of probesets without gene annotation information. Common probesets in both datasets (2888) were further narrowed by analyzing the first 100 upregulated and downregulated probesets in BC samples.

Results
Among the total 400 probesets, 68 were significant for both datasets with similar fold-change values (Pearson r: 0.995). Protein-protein interaction networks demonstrated strong interactions between CCNB1, BUB1B, and AURKB. The HPA database revealed similar protein expression levels for CKAP2L, AURKB, APIP, and LGALS3 both for BC and control samples.

Conclusion
This study disclosed six candidate biomarkers for the early diagnosis of BC. It is suggested that these candidate proteins be investigated in a wet lab to identify their functions in BC pathology and possible treatment approaches.
Antimicrobial sensitivity pattern of children with cystic fibrosis in Bangladesh: a lesson from a specialized Sishu (Children) Hospital
Authors: Sarkar Probir Kumar , Akand Nabila , Tahura Sarabon , Kamruzzaman Md , Akter Johora , Zaman Khandakar Ashikur , Farhana Tanzila , Rima Sathi Sultana , Alam Md Jahangir , Hassan Md. Kamrul , Fardous Jannatul 
Published: December 2022

Abstract
Background
Infection control in cystic fibrosis (CF) patients plays a crucial role in improving the survival of patients with CF. Antimicrobial sensitivity patterns in these patient groups in our country are currently lacking. Therefore, the purpose of the study was to evaluate the microbiological cultures and antimicrobial susceptibility pattern of pediatric CF patients.

Method
A total of 50 respiratory samples were prospectively collected from the period between February 2021 and October 2021. Sputum and oropharyngeal swabs were processed for culture and microbiological testing. Sample collection and evaluation were performed according to the Good Laboratory Practice guidelines (GLP). Informed written consent was ensured before participation. Statistical analysis was performed with SPSS v 26.

Result
The median age of the children was 30 months (6–120) months, with a male predominance (66% vs 34%). Single and two organisms were isolated in 72% (n = 36) and 12% (n = 6) of cases, respectively. During the study period, 36% of the patients harbored Pseudomonas aeruginosa, 18% harbored Klebsiella pneumoniae, and both Staphylococcus aureus and Escherichia coli were detected in 16% of cases. Levofloxacin was found to be the most active antibiotic agent with 100% susceptibility. In contrast, nearly all isolates were resistant to amoxicillin, erythromycin and rifampicin.

Conclusion
Levofloxacin is the most effective agent to treat CF patients. Active surveillance of the resistance pattern should always continue to be promoted.
Binary and ternary inclusion complexation of lapatinib ditosylate with β-cyclodextrin: preparation, evaluation and in vitro anticancer activity
Authors: Mane Preeti Tanaji , Wakure Balaji Sopanrao , Wakte Pravin Shridhar 
Published: December 2022

Abstract
Background
Lapatinib ditosylate, an efficient tyrosine kinase inhibitor for breast cancer, poses pharmacokinetic issues, hence developing its oral delivery system is troublesome. The poor aqueous solubility of this medicament is a key impediment in developing its successful formulation. So, the current study aims to improve water solubility of Lapatinib ditosylate by using complexation technique with β-cyclodextrin and a suitable ternary agent.

Results
Binary and ternary complexes of Lapatinib ditosylate were synthesized by means of kneading and lyophilization using β-cyclodextrin and PVP K30. As a ternary agent, various hydrophilic polymers, as well as organic acids, were assessed, and PVP K30 was chosen for the final formulation based on its stability constant and complexation efficiency. When compared to pure Lapatinib ditosylate, both inclusion complexes demonstrated improved solubility, and drug dissolution. Differential scanning calorimetry (DSC), powder X-ray diffractometry (PXRD), Fourier transform infrared (FTIR), and scanning electron microscopic (SEM) techniques, all validated the complex formation. Docking studies picturized the geometry of Lapatinib ditosylate in β-cyclodextrin cavity. Using MCF-7 cell lines, investigation of anticancer activity of the pure drug and its synthesized complexes was carried out and the results revealed that the complexes had stronger anticancer activity than Lapatinib ditosylate alone.

Conclusions
Overall, it can be concluded that Lapatinib ditosylate complexation increased its aqueous solubility, resulting in its increased dissolution and in vitro anticancer activity in a breast cancer cell line.
Bioactive potential of tropical highland apple (Malus domestica cv. Anna) crude extract: opportunities for food waste revalorization
Authors: Calvo-Castro Laura A. , Lobo-Vázquez Michelle , Gómez-González Julio César , Arnáez-Serrano Elizabeth , Zamora-Fallas Gabriel , Sánchez-Zúñiga Katherine , Centeno-Cerdas Carolina 
Published: December 2022

Abstract
Background
The third most produced fruit crop in the world, apples (Malus domestica Borkh) are one of the most accessible and widely consumed fruits, with known benefits for human health. Although they are a temperate crop, apple cultivation has been successfully implemented in lower latitudes. Tropical highland Costa Rican apples (cv. Anna) have shown high total polyphenol content, and cytotoxic effects against human cancer cell lines. However, most reports originate from purified fractions, obtained using methods which are not easily translatable for commercial applications. In this study, we prepared a polyphenol-rich bioactive extract from Costa Rican Anna apples, using food-grade solvents and simple techniques, aiming towards easy translation of the extraction protocols to small local producers.

Results
The whole apple crude extract (AE) was investigated for its total polyphenol content, general phytochemical profile, cytotoxicity against human breast and lung cancer cells, and regenerative potential in murine skin fibroblast monolayers. The AE showed total polyphenol amounts comparable to that obtained using more refined extractions in previous studies, and exhibited cytotoxic activity against human breast (MCF7) and lung (NCI-H460) cancer cells, and inhibition of cell proliferation in the scratch-wound-healing assay.

Conclusions
Food-grade simple protocols were successful for obtaining a polyphenol-rich bioactive extract from Costa Rican Anna apples. The easy-to-implement extraction protocols and biochemical tests could provide a source of bioactive phytochemicals to be used in circular production systems.
Bilateral congenital lobar emphysema: a rare entity and a therapeutic challenge
Authors: Garge Saurabh , Mahalik Santosh , Jain Pradeep 
Published: December 2022

Abstract

Background

Bilateral congenital lobar emphysema is an extremely rare condition, and detailed workup of these patients is very important. Operative intervention is usually based on radiological, biochemical, and clinical details. Bronchoscopy gives an added advantage in cases with diagnostic dilemmas and makes the treatment more evidence based. We here present three cases and review the literature for this rare entity.

Material and methods
We retrospectively collected data about all the cases of bilateral CLE operated by the authors at various centres over the period of 3 years from January 2016 to December 2018.

Results
We managed three cases of bilateral CLE, and all three had unique details based on which treatment was planned. We operated three cases of this very rare entity and compared our findings with 23 cases from the literature reviewed.

Conclusion
We propose that bronchoscopy should be an essential component in the management of all cases of CLE. It helps in defining pathology, the severity of the disease, and the decision on which side to be operated first and avoids unnecessary simultaneous lobectomies. We recommend case selection on basis of radiological, biochemical, clinical, and bronchoscopy criteria. Based on this, an approach of sequential lobectomies is less risky and should be advocated in most of the patients.
Multiple cystic lung disease in a smoker
Authors: Panjwani Amit , Salman Mohamed Redha 
Published: December 2022

Abstract
Background
Pulmonary cyst is a rounded lung parenchymal lucency, usually containing air or fluid. Approach to establishing the etiology of lung cyst includes determining their location, number, distribution, and presence or absence of associated computed tomography findings (associated with nodules or ground-glass attenuation). Multiple cysts may be seen in various diseases, and radiological imaging is the usual starting point in detecting lung cysts. Importance of adequate clinical examination accompanied with relevant investigations in securing the etiology of lung cysts cannot be overemphasized. We present a first case of a rare multiple cystic lung disease from the Kingdom of Bahrain that was successfully managed with oral corticosteroids.

Case presentation
A 42-year-old male, chronic smoker presented with progressive dyspnea and productive cough of 1 year duration. He was evaluated and found to have multiple variable sized thin and thick-walled cysts with bizarre shapes in both lungs. A diagnosis of pulmonary Langerhans’ cell histiocytosis was made, and the patient was treated with smoking cessation and oral corticosteroids for 9 months.

Conclusion
Patients with characteristic clinical and radiological features can be diagnosed as pulmonary Langerhans’ cell histiocytosis, without a tissue biopsy. A good response may be seen with smoking cessation and oral corticosteroids in selected group of patients.
Transthoracic sonographic scores in evaluating the success of different scelerosing modalities in patients with malignant pleural effusion
Authors: Agmy Gamal , Adam Mohamed F. , El Sagheir Safaa Ahmed , Mahmoud Manal A. 
Published: December 2022

AbstractBackgroundMalignant pleural effusions (MPE) mostly arises from metastases to the pleura from other sites. Management of malignant effusions aims to palliate dyspnea and prevent the reaccumulation of pleural fluid to improve patients’ quality of life. Pleurodesis is the most common palliative treatment for patients with refractory MPE. This study was carried out to evaluate the performance of transthoracic sonographic (TUS) scores (pleural sliding and pleural adherence score) in predicting the success of pleurodesis by different modalities in patients with malignant pleural effusion. One hundred malignant pleural effusion patients were enrolled to an interventional clinical trial from September 2019 to April 2021 for palliative management of dyspnea. Pleurodesis for palliative treatment of dyspnea was done either spontaneously by the intercostal chest tube or by a sclerosing agent such as tetracycline solution or tetracycline poudrage or iodopovidine. Patients were randomly allocated to one of these four groups where each group included 25 patients. Transthoracic ultrasound was performed at baseline, and 1 month after pleurodesis and the lung sliding score and pleural adherence score were evaluated.ResultsMajority of patients (78%) had high baseline lung sliding score (7-8). Post pleurodesis only 11.4% had high scores (p<0.001), also the mean lung sliding score decreased significantly in comparison to the baseline values (p˂ 0.001) in the spontaneous, tetracycline solution, tetracycline poudrage, and iodopovidine groups (7.04 ± 1.02 vs. 4.85 ± 1.60, 7.28± 0.98 vs. 4.48± 1.75, 7.20±0.96 vs. 4.44 ± 1.45, 7.04±0.93 vs. 3.35±1.81, respectively). Iodopovidine pleurodesis group in comparison to the other modalities showed the highest pleural adherence score (12.64 ± 2.98) and absent lung sliding in 72.7% of cases and 70 % success rate. Pleural adherence score at cut off ≥ 12 showed 92.75% sensitivity, 89.47% specificity, 92.1 accuracy, and 0.911 area under the curve (AUC) for predicting successful pleurodesis.ConclusionTUS scores is a feasible, bedside, and accurate method to detect the outcome of pleurodesis. Iodopovidone was more effective than tetracycline solution, tetracycline poudrage, and spontaneous pleurodesis.Trial registrationClinicalTrials.gov. NCT04074902. Registered on 29 August 2019
Cost-effectiveness of implementing a suicide prediction tool (OxMIS) in severe mental illness: Economic modeling study
Authors: Botchway Stella , Tsiachristas Apostolos , Pollard Jack , Fazel Seena 
Published: December 2022

Abstract

Background
Cost-effectiveness analysis needs to be considered when introducing new tools and treatments to clinical services. The number of new assessment tools in mental health has rapidly expanded, including suicide risk assessment. Such suicide-based assessments, when linked to preventative interventions, are integral to high-quality mental health care for people with severe mental illness (SMI). We examined the cost implications of implementing Oxford Mental Illness and Suicide (OxMIS), an evidence-based, scalable suicide risk assessment tool that provides probabilistic estimates of suicide risk over 12 months for people with SMI in England.

Methods
We developed a decision analytic model using secondary data to estimate the potential cost-effectiveness of incorporating OxMIS into clinical decision-making in secondary care as compared to usual care. Cost-effectiveness was measured in terms of costs per quality-adjusted life years (QALYs) gained. Uncertainty was addressed with deterministic and probabilistic sensitivity analysis.

Results
Conducting suicide risk assessment with OxMIS was potentially cheaper than clinical risk assessment alone by £250 (95% confidence interval, −786;31) to £599 (−1,321;−156) (in 2020–2021 prices) per person with SMI and associated with a small increase in quality of life (0.01 [−0.03;0.05] to 0.01 QALY, [−0.04;0.07]). The estimated incremental cost-effectiveness ratio of implementing OxMIS was cost saving. Using probabilistic sensitivity analysis, 99.96% of 10,000 simulations remained cost saving.

Conclusion
Cost-effectiveness analysis can be conducted on risk prediction models. Implementing one such model that focuses on suicide risk in a high-risk population can lead to cost savings and improved health outcomes, especially if explicitly linked to preventative treatments.
Longitudinal Profiling of Plasma Cytokines and Its Association With Postoperative Delirium in Elderly Patients Undergoing Major Lower Limb Surgery: A Prospective Observational Study
Authors: Zhang Yu , Hu Jun , Zuo Weiguang , He Pei , Xue Qi , Feng Xiaomei , Zhang Ye , Maze Mervyn 
Published: December 2022

BACKGROUND:
Surgery is accompanied by a systemic inflammatory response that may presage delirium in susceptible individuals. Little is known about the trajectory of plasma proinflammatory cytokines and their potential associations with postoperative delirium (POD). The current study longitudinally assessed both pro and anti-inflammatory plasma cytokine response and development of POD in older surgical patients to investigate associations with individual and/or clusters of cytokines that may indicate pathogenic mechanisms.

METHODS:
A prospective longitudinal study sought to enroll patients >60 years old who were scheduled for major lower limb surgery under general anesthesia. Blood was obtained preoperatively and postoperatively from day 1 through postoperative day 4 for measurement of plasma interleukin-1β (IL-1β), IL-2, IL-4, IL-6, soluble IL-6 receptor (sIL-6R), IL-10, and tumor necrosis factor-α (TNF-α). Participants were assessed for POD twice daily for 4 days using the confusion assessment method. Trajectory of postoperative changes in plasma cytokines was determined by a group-based trajectory modeling analysis that was informed by distinct cytokines identified by time-dependent Cox regression model.

RESULTS:
One hundred eighty-eight patients were assessed for eligibility of whom 129 underwent major surgery and 126 had complete datasets for final analysis. POD was diagnosed in 31 of 126 patients (24.6%). Time-dependent Cox regression model identified that higher IL-6 and sIL-6R levels were associated with higher risk of developing POD. A two-cluster model (stable lower and fluctuating higher levels) was considered to be the most statistically appropriate model for IL-6 and sIL-6R trajectory. More participants with fluctuating higher IL-6 were delirious (73.3% vs 18.0%, P = .001) as were those with fluctuating higher sIL-6R (81.3% vs 16.4%, P = .001).

CONCLUSIONS:
As higher IL-6 and sIL-6R levels were significantly associated with higher risk of POD and the combination is required for IL-6 trans-signaling, it is possible that activation of this pathway may be associated with POD. Furthermore, it will be important to determine whether high levels of the combination of IL-6 and sIL-6R can be an early biomarker for the subsequent development of POD.