bluuebunny/crossref_metadata_2025_split huggingface dataset:
Caracterização de pacientes pré transplante renal de um hospital referência de Fortaleza-CE
Authors: Leite Sarah Pinheiro de Araújo , Pereira Rikeciane Brandão , Daltro Ana Filomena Camacho Santos , Viana Ana Carolina Cavalcante , Alexandrino Renata Kellen Cavalcante , Lima Valéria Silva de , Leite Lília Teixeira Eufrásio , Melo Priscila Taumaturgo Holanda , Mendonça Priscila da Silva 
Published: June 2022

O estado nutricional prévio dos indivíduos com doença renal crônica terminal possui importante impacto nos desfechos do Transplante Renal. Com isso, o estudo objetivou caracterizar fatores pertinentes ao estado nutricional em pacientes pré transplante renal de um hospital referência de Fortaleza-CE. Caracteriza-se como estudo transversal, descritivo e retrospectivo constituído por 136 pacientes com idade superior a 18 anos de ambos os sexos admitidos para realizar Transplante Renal no período de março de 2018 a março de 2020. Foram coletados e analisados dados clínicos, bioquímicos e antropométricos. As análises estatísticas foram realizadas utilizando o software Statistical Product and Service Solutions - SPSS® (versão 20). Os dados foram analisados pelos testes exato de Fisher, qui-quadrado (χ2), Kolmogorov-Smirnov, t de Student, Mann-Whitney. Foi considerado nível de significância fixado em p < 0,05. Houve associação significativa entre idade e índice de massa corpórea (IMC). Verificou-se que idosos (≥ 60 anos) tiveram maior razão de chance de apresentarem IMC <18,5 kg/m² (p<0,031). De acordo com os dados bioquímicos, maior parte da amostra, apresenta comprometimento nutricional de acordo com contagem total de linfócitos (CTL) e relação linfócito/monócito. Verificou-se que pacientes com idade ≥60 anos apresentaram menor média de relação linfócito/monócito quando comparados aos pacientes com idade <60 anos. Quanto às comorbidades avaliadas, a hipertensão arterial sistêmica (HAS) foi a mais prevalente na amostra. Idosos mostraram-se mais susceptíveis ao quadro de comprometimento nutricional. Diante de diversos fatores que contribuem para esse quadro é de grande importância a avaliação e o acompanhamento clínico e nutricional desses pacientes.
Kalimat Perintah pada Pemeragaan Teknik Ecoprint dalam Kegiatan Pengabdian Masyarakat di SMP Permata Hati Purwokerto
Authors: Pascarina Hanifa 
Published: June 2022

Banyak hal yang harus diperhatikan dalam menyampaikan kalimat perintah/imperatif, termasuk pada siapa kalimat imperatif digunakan. Kalimat perintah yang terdapat dalam pemeragaan teknik Ecoprint dalam kegiatan Pengabdian Masyarakat di SMP Permata Hati Purwokerto ini disampaikan kepada siswa siswi berkebutuhan khusus. Sehubungan dengan hal itu, tulisan ini bertujuan untuk membahas bagaimana bentuk kalimat perintah yang disampaikan pada pemeragaan teknik Ecoprint dalam kegiatan Pengabdian Masyarakat di SMP Permata Hati Purwokerto. Sumber data adalah kalimat perintah dalam pemeragaan Ecoprint dalam kegiatan pengabdian masyarakat “Teknik Pembuatan Ecoprint untuk Siswa Siswi SMP Permata Hati Purwokerto (Kreasiku: Ecoprint sebagai media meningkatkan pengetahuan dan keterampilan Anak Berkebutuhan Khusus)”. Dalam analisis data menggunakan metode padan intralingual, sedangkan untuk teknik validitas data menggunakan metode trianggulasi teori. Kalimat perintah yang terdapat pada Pemeragaan Teknik Ecoprint dalam Kegiatan Pengabdian Masyarakat “Teknik Pembuatan Ecoprint untuk Siswa Siswi SMP Permata Hati Purwokerto (Kreasiku: Ecoprint sebagai media meningkatkan pengetahuan dan keterampilan Anak Berkebutuhan Khusus)”, meliputi kalimat perintah yang sebenarnya, kalimat perintah ajakan, dan kalimat perintah larangan.
TEMBIKAR PADA GUA LADORI DI DESA BENDEWUTA KECAMATAN OHEO KABUPATEN KONAWE UTARA PROVINSI SULAWESI TENGGARA (KAJIAN BENTUK DAN RAGAM HIAS)
Authors: Aksan Aksan , Syahrun Syahrun 
Published: June 2022

Penelitian ini bertujuan untuk mengetahui bentuk dan ragam hias tembikar di Gua Ladori dan teknik pembuatan ragam hias. Penelitian ini menggunakan teori Sa Huynh-Kalanay, Out Of Taiwan dan Sejarah Budaya. Penelitian kualitatif adalah suatu prosedur pengambilan data yang menghasilkan data deskriptif berupa kata-kata tertulis. Teknik pengumpulan data yang digunakan berupa studi pustaka dan observasi. Tahap pengolahan data mengunakan analisis morfologi, analisis teknologi dan analisis stilistik.
Hasil penelitian ini menunjukan bentuk-bentuk gerabah yang ditemukan di Gua Ladori. Berdasarkan hasil rekonstruksi yang diambil dari 41 sampel, dari jumlah tersebut terdapat 31 fragmen tembikar yang dapat direkonstruksi 15 diantaranya berupa periuk, 7 diantaranya tutupan, 3 mangkuk, 3 mangkuk berkaki dan 10 diantara tidak dapat di rekonstruksi. Berdasarkan hasil analisis ragam hias tembikar yang terdapat di Gua Ladori berupa geometris yang terdiri dari 6 ragam hias yang dapat diidentifikasi yaitu garis berjumlah 4, belah ketupat berjumlah 12, lingkaran berjumlah 4, empat persegi berjumlah 2 dan segitiga berjumlah 1. Berdasarkan analisis teknik pembuatan ragam hias terdiri dari 4 teknik yaitu teknik tekan berjumlah 22, teknik tusuk berjumlah 2, teknik gores berjumlah 8 dan teknik tempel berjumlah 1.
IDENTIFIKASI SITUS BENTENG BAADIA (Studi Kasus Terhadap Tinggalan Arkeologi di Benteng Baadia Kelurahan Baadia Kecamatan Murhum Kota BauBau)
Authors: Fizar Amat Al 
Published: June 2022

Penelitian ini menjelaskan tentang tinggalan arkeologis yang berada di Benteng Baadia di Kelurahan Murhum Kecamatan Baadia Kota BauBau dan fungsi benteng tersebut. Tujuan dari penelitian ini adalah untuk mengetahui tinggalan arkeologis dan yang berada di benteng tersebut serta fungsi benteng berdasarkan tinggalan-tinggalannya. Model Penelitian ini menggunakan ruang skala makro. Untuk mengetahui hubungan lokasianal antaran tinggalan dan fungsi benteng serta menggunakan analisis kontekstual sebagai analisis pendukung. Berdasarkan hasil penelitian diperoleh kesimpulan bahwa tinggalan-tinggalan arkeologis yang ditemukan di Benteng Baadia adalah meriam atau badhili, struktur bangunan masjid, umpak batu, fragmen keramik, fragmen gerabah dan moluska. Fungsi benteng berdasarkan tinggalannya adalah sebagai benteng pertahanan dan benteng pemukiman.
TEMBIKAR PADA GUA TENGKORAK 1 DESA WAWONTOAHO KECAMATAN WIWIRANO KABUPATEN KONAWE UTARA (Kajian Ragam Hias)
Authors: Handayani Saputri , Salniwati Salniwati 
Published: June 2022

Di Sulawesi Tenggara banyak tersebar Gua â€“ Gua Prasejarah dengan temuan didalamnya sangat beragam. Salah satu gua tersebut adalah Gua Tengkorak yang terdapat di Wilayah administrasi Desa Wawontoaho Kecamatan Wiwirano Kabupaten Konawe Utara. Di gua tersebut menyimpan banyak tinggalan terutama tembikar. Melihat ragam hias tembikar yang beragam menarik untuk dilakukan penelitian.
Penelitian ini bertujuan untuk mengetahui bentuk dan teknik ragam hias tembikar Gua Tengkorak 1. Penelitian ini menggunakan jenis penelitian kualitatif dengan penalaran induktif. Penelitian ini menggunakan metode pengumpulan data berupa observasi, data tertulis dan dokumentasi. Ada dua analisis data yang digunakan yaitu (1) Analisis Stilistik dan, (2) Analisis Teknologi. Hasil dari penelitian ini menjelaskan tentang teknik pembuatan ragam hias serta bentuk ragam hias yang dihasilkan pada tembikar di gua tengkorak 1.
Jumlah sampel yang digunakan dalam penelitian ini adalah 62. Berdasarkan analisis ragam hias terdapat 6 ragam hias yaitu, garis, bulatan, segitiga, segiempat, titik dan belah ketupat. Sedangkan penerapan teknik ragam hias terdapat 5 teknik yaitu, teknik gores, teknik tempel, teknik tusuk, teknik tekan dan teknik cungkil.
Blood Pressure Trajectories From Childhood to Youth and Arterial Stiffness in Adulthood: A 30-Year Longitudinal Follow-Up Study
Authors: Chu Chao , Liao Yue-yuan , He Ming-jun , Ma Qiong , Zheng Wen-ling , Yan Yu , Hu Jia-wen , Xu Xian-jing , Fan Ya-ning , Yang Rui-hai , Mu Jian-jun 
Published: June 2022

BackgroundThis study aimed to identify the subgroups of individuals sharing similar blood pressure (BP) trajectories from childhood to youth and explore the associations of these trajectories with arterial stiffness in adulthood.MethodsA group-based trajectory model was used to identify BP trajectories among 2,082 individuals in the Hanzhong adolescent hypertension cohort by using BP values repeatedly measured at four visits from childhood (6–15 years) to youth (14–23 years). The brachial–ankle pulse wave velocity (baPWV) was examined 30 years after the baseline survey. Mixed linear regression models were used to examine the associations of these trajectories with adult baPWV.ResultsAmong the 2,082 individuals, three trajectory groups of systolic BP were identified as follows: the low-level group (n = 889), medium-level group (n = 1,021), and high-level group (n = 172). The baPWV in adulthood was higher in medium-level and high-level groups compared with the low-level group (1271.4 ± 224.7 cm/s, 1366.1 ± 249.8 cm/s vs. 1190.1 ± 220.3 cm/s, all p &lt; 0.001). After adjustment for potential confounding factors, the association between baPWV and systolic BP trajectories was statistically significant (adjusted β = 49.4 cm/s; p &lt; 0.001 for the medium-level group and β = 107.6 cm/s; p &lt; 0.001 for the high-level group compared with the low-level group). Similar results were obtained for the association of baPWV with the trajectories of diastolic BP and mean arterial pressure (MAP), except for pulse pressure.ConclusionOur investigation demonstrates different BP trajectories from childhood to youth and shows the trajectories of systolic BP, diastolic BP, and MAP are significant predictors of arterial stiffness in adulthood.
Dominant Myocardial Fibrosis and Complex Immune Microenvironment Jointly Shape the Pathogenesis of Arrhythmogenic Right Ventricular Cardiomyopathy
Authors: Lu Wenzhao , Li Yao , Dai Yan , Chen Keping 
Published: June 2022

BackgroundArrhythmogenic right ventricular cardiomyopathy (ARVC) is a heritable life-threatening myocardial disease characterized by ventricular arrhythmias and sudden cardiac death. Few studies used RNA-sequencing (RNA-seq) technology to analyze gene expression profiles, hub genes, dominant pathogenic processes, immune microenvironment in ARVC. This study aimed to explore these questions via integrated bioinformatics analysis.MethodsRNA-sequencing datasets of GSE107475, GSE107311, GSE107156, and GSE107125 were obtained from the Gene Expression Omnibus database, including right and left ventricular myocardium from ARVC patients and normal controls. Weighted gene co-expression network analysis identified the ARVC hub modules and genes. Functional enrichment and protein-protein interaction analysis were performed by Metascape and STRING. Single-sample gene-set enrichment analysis (ssGSEA) was applied to assess immune cell infiltration. Transcription regulator (TF) analysis was performed by TRRUST.ResultsThree ARVC hub modules with 25 hub genes were identified. Functional enrichment analysis of the hub genes indicated that myocardial fibrosis was the dominant pathogenic process. Higher myocardial fibrosis activity existed in ARVC than in normal controls. A complex immune microenvironment was discovered that type 2 T helper cell, type 1 T helper cell, regulatory T cell, plasmacytoid dendritic cell, neutrophil, mast cell, central memory CD4 T cell, macrophage, CD56dim natural killer cell, myeloid-derived suppressor cell, memory B cell, natural killer T cell, and activated CD8 T cell were highly infiltrated in ARVC myocardium. The immune-related hub module was enriched in immune processes and inflammatory disease pathways, with hub genes including CD74, HLA-DRA, ITGAM, CTSS, CYBB, and IRF8. A positive linear correlation existed between immune cell infiltration and fibrosis activity in ARVC. NFKB1 and RELA were the shared TFs of ARVC hub genes and immune-related hub module genes, indicating the critical role of NFκB signaling in both mechanisms. Finally, the potential lncRNA–miRNA–mRNA interaction network for ARVC hub genes was constructed.ConclusionMyocardial fibrosis is the dominant pathogenic process in end-stage ARVC patients. A complex immune microenvironment exists in the diseased myocardium of ARVC, in which T cell subsets are the primary category. A tight relationship exists between myocardial fibrosis activity and immune cell infiltration. NFκB signaling pathway possibly contributes to both mechanisms.
RELAYTM Branched–International Results of Vessel Patency and Reintervention
Authors: Singh Sidhant , Surkhi Abedalaziz O. , Tan Sven Z. C. P. , Jubouri Matti , Bailey Damian M. , Williams Ian , Bashir Mohamad 
Published: June 2022

BackgroundSurgical intervention remains the mainstay treatment for aortic arch aneurysm and dissection, but the high mortality and morbidity rates have led to a need for the development of minimally invasive alternatives to arch reconstruction. RELAY™ Branched (Terumo Aortic, Inchinnan, UK) represents a viable option for complex endovascular aortic arch repair. We present multi-center data from Europe documenting the efficacy of the endograft in terms of its target vessel patency and reintervention rates.MethodsProspective data collected between January 2019 and January 2022 associated with patients treated with RELAY™ single-, double-, and triple-branched endoprostheses from centers across Europe was retrospectively analyzed with descriptive and distributive analysis. Follow up data from 30 days and 6-, 12-, and 24 months postoperatively was included. Patient follow up was evaluated in terms of target vessel patency and reintervention rates.ResultsTechnical success was achieved in 147 (99.3%) cases. Over 24 months period, target vessel patency was maintained in 80.2% (n = 118) of patients. Target vessel cannulation was achieved in 146 (99.3%) cases. Over the 24-month follow-up period, 30 reintervention procedures were required, of which 29 (97%) took place within the South Europe region which accounted for 19.6% (n = 29) of total cases. Zero reinterventions were required in patients that were treated with single- or triple-branched endoprostheses.DiscussionThe data presented herein demonstrates that RELAY™ Branched is a technically efficacious device for endovascular aortic arch repair and is associated with favorable target vessel patency and reintervention rates. Key design features of the endoprosthesis and good perioperative management can contribute greatly to mitigating reintervention and loss of vessel patency following endovascular aortic arch repair.
GnRH Antagonist Protocol Versus GnRH Agonist Long Protocol: A Retrospective Cohort Study on Clinical Outcomes and Maternal-Neonatal Safety
Authors: Zhu Jieru , Xing Weijie , Li Tao , Lin Hui , Ou Jianping 
Published: June 2022

ObjectiveTo evaluate the clinical outcomes and maternal-neonatal safety of gonadotropin releasing hormone antagonist (GnRH-ant) and gonadotropin releasing hormone agonist (GnRH-a) protocols.MethodsA total of 2505 women undergoing their first in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI) were retrospectively analyzed. Patients were divided into GnRH-ant group (n = 1514) and GnRH-a group (n = 991) according their stimulation protocol. Propensity Score Matching (PSM) was used for balancing the baseline of two groups. The pregnancy outcomes were analyzed in fresh transfer cycles, and the obstetric and perinatal outcomes were calculated in singleton live births of fresh cycles. The primary outcome was the live birth rate. The secondary outcome measures were maternal complications, preterm birth rate, low birthweight rate, multiple pregnancy rate, and moderate-severe OHSS rate.ResultsAfter 1:1 PSM, baseline characteristics of the GnRH-ant group and GnRH-a group were matched and assigned 991 cycles in each group. Before PSM, there were 700 fresh cycles including 237 singleton live births in the GnRH-ant group and 588 fresh cycles including 187 singleton live births in the GnRH-a group. After PSM, there were 471 fresh cycles including 166 singleton live births in the GnRH-ant group and 588 fresh cycles including 187 singleton live births in the GnRH-a group. No significant differences were observed in the live birth rate (44.6% vs 48.8%), maternal complications, preterm birth rate (9.0% vs 6.4%), and low birthweight rate (17.5% vs 24.1%) between two groups after PSM (P &gt; 0.05). The moderate-severe OHSS rate (2.9% vs 6.0%, P = 0.002) and multiple pregnancy rate (24.5% vs 33.1%, P = 0.025) was significantly lower in the GnRH-ant group than that in the GnRH-a group after PSM.ConclusionGnRH-ant protocol was comparable with GnRH-a protocol in clinical outcomes, obstetric and perinatal outcomes, and with a lower risk of OHSS. For those who want to get an effective and safe outcome, and a shorter treatment period, GnRH-ant is a suitable choice.
Immunological Changes of Basophil Hyperreactivity to Sweat in Patients With Well-Controlled Atopic Dermatitis
Authors: Numata Tomofumi , Takahagi Shunsuke , Ishii Kaori , Morioke Satoshi , Kan Takanobu , Mizuno Hayato , Yanase Yuhki , Kawaguchi Tomoko , Tanaka Akio , Hide Michihiro 
Published: June 2022

BackgroundSweat aggravates atopic dermatitis (AD). In patients with AD, type-I hypersensitivity to sweat may be shown by histamine release from patients’ basophils in response to the semi-purified sweat antigen (QR), and the presence of specific immunoglobulin E (IgE) binding to MGL_1304, the component of QR. However, there has been no information on the immunological changes of type-I hypersensitivity to the sweat antigen in patients with well-controlled AD using topical corticosteroids (TCSs) and/or biologics as treatments.MethodHistamine-releasing tests using patients’ basophils and QR and the detection of serum IgE against MGL_1304 and mite allergen Der f 1 were performed in patients with AD who were well controlled by topical TCS with/without dupilumab for 53–96 weeks.ResultsIn total, 14 patients were enrolled. Seven patients received TCS therapy alone (TCS group), and seven patients received TCS with dupilumab therapy (dupilumab group). In all participants, the level of specific IgE against MGL_1304 decreased after treatments, but histamine release from basophils in response to QR did not show a statistically significant reduction; rather, it increased. In the dupilumab group, all changes in histamine release induced by QR (increase), the IgE level against MGL_1304 (decrease), and that against Der f 1 (decrease) were statistically significant, whereas the TCS group showed no significant change in any of them.ConclusionThe well-controlled condition for 53–96 weeks resulted in no reduction of the hyperreactivity of basophils against in patients with AD, even with the treatment with dupilumab. This study suggests persistent basophil hyperreactivity to sweat antigen over a year or longer.
Association of COVID-19 Case-Fatality Rate With State Health Disparity in the United States
Authors: Lee Yu-Che , Chang Ko-Yun , Mirsaeidi Mehdi 
Published: June 2022

BackgroundThe disproportionate burden of COVID-19 pandemic has become a major concern in the United States (US), but the association between COVID-19 case-fatality rate (CFR) and factors influencing health outcomes at a state level has not been evaluated.MethodsWe calculated COVID-19 CFR for three different waves using COVID Data Tracker from the Centers for Disease Control and Prevention. America's Health Rankings assesses the factors that influence health outcomes to determine state's health rankings. The association between COVID-19 CFR and state health disparities was analyzed by linear regression.ResultsStates with better rankings of Physical Environment were associated with lower CFR for the 1st wave (β = 0.06%, R2 = 0.170, P = 0.003). There was a paradoxical association between the 2nd wave CFR and Clinical Care (β = −0.04%, R2 = 0.112, P = 0.017) and Overall health rankings (β = −0.03%, R2 = 0.096, P = 0.029). For the 3rd wave, states with better rankings of Overall health factors (β = 0.01%, R2 = 0.179, P = 0.002), Social &amp; Economic Factors (β = 0.01%, R2 = 0.176, P = 0.002), Behaviors (β = 0.01%, R2 = 0.204, P &lt; 0.001), and Health Outcomes (β = 0.01%, R2 = 0.163, P = 0.004) were associated with lower CFR. COVID-19 vaccination coverage was also associated with state health rankings (at least one dose: β = −0.13%, R2 = 0.305, P &lt; 0.001; fully vaccinated: β = −0.06%, R2 = 0.120, P = 0.014).ConclusionsThese findings suggested targeted public health interventions and mitigation strategies addressing health disparities are essential to improve inequitable outcomes of COVID-19 in the US.
Association of Lesion Location and Fatigue Symptoms After Ischemic Stroke: A VLSM Study
Authors: Wang Jinjing , Gu Mengmeng , Xiao Lulu , Jiang Shiyi , Yin Dawei , He Ye , Wang Peng , Sun Wen , Liu Xinfeng 
Published: June 2022

Background:Poststroke fatigue (PSF) is a common symptom in stroke survivors, yet its anatomical mechanism is unclear. Our study was aimed to identify which brain lesions are related to the PSF in patients with acute stroke.MethodPatients with first-ever acute ischemic stroke consecutively admitted from the first affiliated hospital of the University of Science and Technology of China (USTC) between January 2017 and June 2020. Fatigue was scored using the Fatigue Severity Scale. All the participants were assessed by 3.0 T brain MRI including diffusion-weighted imaging. The infarct lesions were delineated manually and transformed into a standard template. Voxel-based lesion-symptom mapping (VLSM) was applied to investigate the association between lesion location and the occurrence and severity of fatigue. The same analyses were carried out by flipping the left-sided lesions. Multivariate logistic regressions were applied to verify the associations.ResultsOf the 361 patients with acute stroke, 142 (39.3%) patients were diagnosed with fatigue in the acute phase and 116 (35.8%) at 6 months after the index stroke. VLSM analysis indicated clusters in the right thalamus which was significantly associated with the occurrence and severity of PSF at 6-month follow-up. In contrast, no significant cluster was found in the acute phase of stroke. The flipped analysis did not alter the results. Multivariate logistic regression verified that lesion load in the right thalamus (OR 2.67, 95% CI 1.46–4.88) was an independent predictor of 6-month PSF.ConclusionOur findings indicated that lesions in the right thalamus increased the risk of fatigue symptoms 6 months poststroke.