bluuebunny/crossref_metadata_2025_split huggingface dataset:
Magnetic resonance texture analysis is superior to magnetization transfer imaging for longitudinal assessment of fibrosis
Authors: Bos Simon , De Kock Isabelle , Delrue Louke , Welden Sophie Van , Bunyard Peter , Hindryckx Pieter , de Vos Martine , Villeirs Geert , Laukens Debby 
Published: May 2022

Abstract
A common and untreatable complication of Crohn’s disease (CD) is the development of intestinal fibrosis for which no adequate noninvasive tools for fibrosis progression monitoring exist. For this purpose, we assessed the performance of magnetization transfer (MT) magnetic resonance imaging (MRI) and texture analysis (TA) on T2-weighted images by correlating them with histology in a fibrosis mouse model. MT-MRI and TA performance was validated during antifibrotic therapy in mice and on MR enterography images of CD patients undergoing bowel surgery. The MT-MRI and TA entropy correlated with histological fibrosis (r = .85 and .81, respectively). However, TA entropy was superior to MT-MRI for quantifying fibrosis progression during coexisting inflammation (linear regression R² = .93). TA entropy could efficiently monitor anti-fibrotic therapy efficacy and correlated with the grade of intestinal fibrosis in CD. In conclusion, MT-MRI and TA entropy are highly promising surrogate markers of intestinal fibrosis, but TA entropy performed better in the presence of concomitant inflammation.
Single-Year and Double-Year El Niños
Authors: GAO Zongting , Hu Zeng-Zhen , Zheng Fei , Li Xiaofan , Li Shangfeng , Zhang Banglin 
Published: May 2022

Abstract
Compared with well documented and frequent occurrence of multi-year La Niña, double-year El Niño is less frequent and has not been well investigated. Both of them are a discrepancy from the cyclic behavior of the El Niño-Southern Oscillation and deserve investigation. During 1950-2021, 75% of El Niño events persist for one year, and 25% of them last for two years. Both central and eastern Pacific type El Niños occur in the single-year and double-year El Niños with various strengths. Compared with the single-year El Niños, the averaged warm water volume (WWV) is larger in the peak and declines much slower for the double-year El Niños, suggesting that a persistently recharged heat condition of the equatorial Pacific is a precondition for the emergence of a second-year El Niño. The faster decline of WWV in the single-year El Niños is associated with the in-phase decrease of its intraseasonal-interseasonal and interannual components, while the slower decline of WWV in the double-year El Niños is determined by the interannual component. In addition, the single-year and double-year El Niño may have different impacts on regional climate.
High efficient semi-transparent organic solar cell with non-fullerene acceptor: the role of structural parameters on efficiency and transparency
Authors: Milani Elmira Annabi , Piralaee Mina , Ahmadi Sohrab , Asgari Asghar 
Published: May 2022

Abstract
Semitransparent organic solar cells are attracted recently because they harvest photons in the near-infrared and ultraviolet range and pass in the visible light region. Semitransparent organic solar cells with ITO/ ZnO/ PBDB-T: ITIC/ MoO3/Ag/MoO3 structure have been studied in this work. The effects of active layer thicknesses and the transparent top electrode, MoO3/Ag/MoO3, thickness on the solar cell performance such as I-V characteristics, the power conversion efficiency, the average visible transmittance, and the color coordinates in the CIE color space are investigated. The drift-diffusion model, including the density of excitons, and their displacement is used to model the devices. The model is examined with experimentally reported devices, then applied to the new structures. The obtained results are in very good agreement in comparison with experimental data.
A systematic mapping and bibliometric analysis of systematic reviews of health economic evaluations: A protocol
Authors: Haslberger Martin , Martinez-Gamboa Lorena , Ioannidis John P A , Mathes Tim , Belbasis Lazaros 
Published: May 2022

Abstract
Background: Systematic reviews of health economic evaluations (SR-HEs) provide a critical tool for synthesizing published literature to guide decision makers towards implementing evidence-based policy and healthcare practice. However, the quality of the methodology and reporting of SRs is often flawed due to insufficiencies in their design, conduct and reporting. Meta-research has led to methodological improvements in many research fields but is not widely established in health economic evidence synthesis. To enable future meta-research on SR-HEs, we will create a database of SR-HEs and provide a bibliometric analysis of this literature.Methods: We will perform a systematic search in MEDLINE for systematic reviews with/without meta-analyses of health economic evaluations. We will include studies that performed a systematic review of cost-effectiveness, cost-minimization, cost-utility, cost-benefit, and/or cost-consequence analyses. We will automatically extract data from Ovid MEDLINE and Web of Science to conduct a bibliometric analysis by examining publication, citation, and collaboration patterns.Discussion: Our study will provide a map of SR-HEs accompanied by a thorough bibliographic analysis of this research field. Our publicly accessible database can be used to assist future research and meta-research efforts in the field of health economics. Our bibliometric analysis will provide insights into the evolution of this research field over the years in terms of publications, citations, and scientific collaborations.Preregistration: 10.17605/OSF.IO/PV6XJ
Circulating miR-20b-5p and miR-330-3p Are Novel Biomarkers for Progression of Atrial Fibrillation: Intracardiac/Extracardiac Plasma Sample Analysis by Small RNA Sequencing
Authors: Harada Masahide , Okuzaki Daisuke , Yamauchi Akemi , Ishikawa Shiho , Nomura Yoshihiro , Nishimura Asuka , Motoike Yuji , Koshikawa Masayuki , Hitachi Keisuke , Tsuchida Kunihiro , Amano Kentaro , Maekawa Atsuo , Takagi Yasushi , Watanabe Eiichi , Ozaki Yukio , Izawa Hideo 
Published: May 2022

Abstract
Background: Circulating miRNA expression in the peripheral blood samples might not reflect a cardiac phenomenon since most miRNAs are expressed in numerous organs. This study aimed to identify the cardiac-specific circulating miRNAs as biomarkers for atrial fibrillation (AF).Methods: Plasma samples were obtained from a luminal coronary sinus catheter (CS, cardiac-specific samples) and femoral venous sheath (FV, peripheral samples) in AF patients and controls undergoing catheter ablation (CA). Small RNA sequencing was performed to identify differently expressed miRNAs between AF and CTL in each sample of the CS and FV; miRNAs exhibiting similar expression profiles in the CS and FV samples were selected as candidates for cardiac-specific biomarkers, and were related to the outcome of CA of AF.Results: Among the top 30 most differently expressed miRNAs between AF and CTL, circulating hsa-miR-20b-5p/miR-330-3p/miR-204-5p had a similar pattern in the CS and FV samples. Another set of peripheral samples was obtained from AF patients undergoing CA (n=141). The miR-20b-5p/miR-330-3p expressions negatively correlated with the echocardiographic left-atrial dimension and was significantly decreased in patients with AF recurrence as compared to those without AF recurrence.Conclusion: Circulating miR-20b-5p/miR-330-3p can be cardiac-specific biomarkers for atrial remodeling and arrhythmia recurrence after CA in AF patients.
CCMMI: A class center-based multiple mixed imputation method
Authors: Miao Shi-di , Hu Xiao-hui , Cheng Jia 
Published: May 2022

Abstract
Missing data is ubiquitous in the real society. Multiple imputation (MI) reflects the uncertainty of missing data and makes full use of existing data. It is an effective method to deal with missing data. However, when MI considers the imputation model, the optimal single model is usually selected from candidate ones to impute multiple times, thus ignoring the uncertainty of model selection. Therefore, this paper introduces a class center-based multiple mixed imputation method (CCMMI), which takes both data and model selection uncertainties into account to obtain better imputation results than MI method of other single models. It mainly determines an imputation threshold by measuring the Euclidean distance between the class center and each class of data samples, and then uses multiple single models to generate multiple different imputation datasets. Finally, it uses the imputation threshold to determine the optimal interpolation in the imputation datasets. The experimental results on numerical, categorical and mixed datasets with different missing rates show that the performance of CCMMI method is better than that of other single models with missing rates ranging from 10–50%.
Association of GWAS and candidate gene loci of dopaminergic system with major depression, schizophrenia and bipolar disorder in the Pakistani population
Authors: Hashmi Aisha Nasir , Dharejo Raees Ahmed , Taj Rizwan , Ajmal Muhammad , khan Netasha , Agha Zehra , Qamar Raheel , Azam Maleeha 
Published: May 2022

Abstract
The dopaminergic pathways control neural signals that modulate mood and behaviour along and have a vital role in the aetiology of major depression (MDD), schizophrenia (SHZ) and bipolar disorder (BD). Genome-wide association studies (GWAS) have reported several dopaminergic pathway’s and other genetic loci’s association with these disorders, therefore, the present study was conducted to analyse the GWAS and candidate gene loci of the dopaminergic and cognitive system genes in MDD, SHZ, and BD, in the Pakistani population. A total of 1237 subjects [MDD n = 479; BD n = 222; SHZ n = 146; and controls n = 390], were screened for eleven genetic variants through polymerase chain reaction (PCR) techniques. Univariant followed by multivariant logistic regression analysis were applied to determine the genetic association. Significant risk associations were observed for rs4532 and rs1799732 with MDD; and rs1006737 and rs2238056 with BD. However, after applying multiple test corrections rs4532 and rs1799732 association did not remain significant for MDD. Moreover, a protective association was found for three variants DRD4-120bp, rs10033951 and rs2388334 in the current cohort. Thus, in conclusion, the current study revealed the risk association of rs1006737 and rs2238056 with BD and the protective effect of DRD4-120bp in MDD and BD, of rs2388334 in BD and of rs10033951 in MDD, BD, and SHZ in the current Pakistani cohort.
Techniques for Predicting Dark Web Events Focused on the Delivery of Illicit Products and Ordered Crime
Authors: Rawat Romil , AJAGBE Sunday Adeola , OKI Olukayode A 
Published: May 2022

Abstract
The techniques for forecasting crime in detail before it occurs, or creating an "Automated Machine" to assist police officers, relieves the strain on cops while also aiding in crime prevention. We recommend incorporating machine learning (ML) with computer vision (CV) methodologies to accomplish and discuss the outcomes of a few situations in which such techniques were employed. The goal of this research is to present the dark web crime statistics and forecasting model for generating alerts of illicit activities like drug supply, human trafficking, terrorist radicalization and recruitment, and weapon delivery, online killing orders, and fraudulent activities that are associated with gangs or organizations showing online presence using ML and CV to assist law enforcement organizations to analyze, identify, and generate strategic techniques for solving cyber crime cases more accurately and quickly.
Effectiveness of Carbonic Anhydrase Inhibitor Loaded Nanoparticles in the Treatment of Diabetic Retinopathy
Authors: Uğurlu Nagihan , Erdal Ebru , Malekghasemi Soheil , Demirbilek Murat 
Published: May 2022

Abstract
DRP is a disease consisting of all the structural and functional changes that develop in the retinal layer of the eye due to diabetes. DRP is the most important cause of blindness between the ages of 20-74 in the world, and the most successful standard treatment option in the treatment of DRP is intravitreal injections. To synthesize acetazolamide loaded nanoparticles to be applied intravitreal treatment of DRP and to examine the in vitro efficacy of the nanoparticles. ACZ loaded PHBV nanoparticles (PHBV-ACZ NPs) formulations were prepared. Nanoparticles with a particle size of 253.20±0.55nm. A DRP model was established and characterized in HRMEC cells. The effect of the nanoparticles on permeability has been investigated and carrier proteins in BRB due to the development of DRP has been investigated. To establish the in vitro DRP model, HRMEC was stimulated with Recombinant human 165 Vascular Endothelial Growth Factor (VEGF), thereby temporarily reducing the expression levels of endothelial junction proteins, increasing the number of intercellular spaces in the monolayers of HRMECs. It was determined that after the cells were exposed to Carbonic anhydrase inhibitors (CAI) loaded nanoparticles, permeability decreased and protein expression increased.
Correlation Between Default Mode Network and Symptomatic Domains: A Spectral Approach to Schizophrenia
Authors: Sánchez Ana Maria Granados , Zapata Juan Felipe Orejuela , Dávila Cesar Augusto Arango , Arango Isabella Moreno 
Published: May 2022

Abstract
Introduction
When evaluating psychiatric pathologies using imaging studies, the categorical approach supposes a significant challenge. Redefining these pathologies with the use of behavioral dimensions that are related to brain biology has been attempted. This paper aims to describe the findings on functional magnetic resonance imaging in patients with schizophrenia and correlate it with their symptomatic domains.
Materials and methods
This study is a descriptive, observational, transversal study. Fourteen patients with schizophrenia and Fourteen controls were explored using functional magnetic resonance during a resting period and developing easy, medium, and complex tasks. The default mode network was evaluated, registering the voxel activation on a cluster and its maximum activation over interest areas. Subjects were interrogated using the Derogatis Symptom Checklist (SCL-90-R) and correlation coefficients were applied for data analysis.
Results
Diminished activation of the default mode network was evidenced in association with the complexity of the task in the control group. Patients presented a steady activation when comparing their resting state with the activation during the different tasks. A negative correlation was observed implicating the volume of the functional cluster in the posterior cingulate cortex during the high complexity task and the interpersonal sensitivity domain. A moderate positive correlation was found with symptomatic domains of interpersonal sensitivity, hostility, phobia, and depression, while a moderate negative association was found with psychosis.
Conclusions
Imaging evaluation of the psychiatric pathologies could be useful if the pathology is approached through the spectrum of symptomatic domains. This perspective would enhance the assertiveness of the therapeutics.
White matter hyperintensities in cholinergic pathways may predict poorer responsiveness to acetylcholinesterase inhibitor treatment for Alzheimer disease
Authors: Lee Li-Hua , Wu Shu-Ching , Ho Cheng-Feng , Liang Wan-Lin , Liu Yi-Chien , Chou Chia-Ju 
Published: May 2022

Abstract
BackgroundAcetylcholinesterase inhibitor (AChEI) drug regimens are the mainstay treatment options for patients with Alzheimer disease (AD). Herein, we predicted clinical responses to AChEI treatment from baseline neuroimaging parameters. MethodsBetween 2020 and 2021, we recruited 101 individuals with a clinical diagnosis of probable AD. Each participant underwent complete neuropsychological testing and 3T brain magnetic resonance imaging (MRI). Responsiveness to donepezil, as assessed after 12 months, was designated as less than two points of regression in Mini-Mental State Examination scores. We also evaluated MRI images by examining scores on the Cholinergic Pathways Hyperintensities Scale (CHIPS), Fazekas scale, and medial temporal atrophy (MTA) scale. ResultsIn our cohort, 52 patients (51.4%) were classified as responders. We observed significantly higher CHIPS scores in the nonresponder group (21.1 ± 12.9 vs. 14.9 ± 9.2, P = 0.007). Age at baseline, education level, sex, Clinical Dementia Rating sum of boxes scores, and three neuroimaging parameters were tested in regression models. Only CHIPS scores predicted clinical response to AChEI treatment. ConclusionWMHs in the cholinergic pathways, not diffuse white matter lesions or hippocampal atrophy, correlated with poorer responsiveness to AChEI treatment. Therefore, further investigation into the role of the cholinergic pathway in AD is warranted.
Stress and depression of university students in Egypt during the COVID-19 pandemic
Authors: Soliman Asmaa Mohamed Ahmed , Mabrouk Shimaa Elsayed Mohammed , Hagag Radwa Samir , Ghandour Ahmed A , Mekhamier Hanem Awad , Elsherbeny Enas Elsayed 
Published: May 2022

Abstract
Background: Mental health issues have been increasing globally, especially among university students. The pandemic of COVID-19 has aggravated this pre-existing and serious problem. This study aimed to assess the stress and depression levels and mental health status of Egyptian university students during the COVID-19 pandemic.Methods: A cross-sectional online survey was conducted on medical and non-medical Egyptian university students. A total of 1470 participants completed the electronic anonymous online survey containing Patient Health Questionnaire-9 (PHQ-9) and Perceived Stress Scale(PSS). Results: Of the 1470 participants, 10.9% have moderately severe depression and 6.1% have severe depression. Moreover, 77.6% reported moderate stress, 16.3% reported low stress, and 6.2% reported high stress. There was strong positive correlation between depression and stress among participants (r = 0.815) (p < 0.001). The significant predictors for depression were age between 18 and 20 years, female sex, presence of chronic diseases, and presence of friends or relatives diagnosed with COVID-19. The significant predictors for stress were age between 18 and 20 years, female sex, presence of friends or relatives diagnosed with COVID-19, and medical faculties.Conclusions: During the COVID-19 pandemic, a majority of university students of Egypt showed moderate to high level of stress, and about one-third of them had moderate to severe depression. Younger age, female sex and having a relative or friend diagnosed with COVID-19 were significant predictors for high stress level and depression. Psychological interventions for university students during the COVID-19 pandemic are strongly recommended to promote their mental health and improve academic achievement.
RAB10 involving in glucose uptake by regulating GLUT1 predicts poor prognosis in pancreatic cancer
Authors: Cai Lijie , Han Jinrui , Wu Junqing , Ge Xinyu , Liu Peng , Duan Heng , Liu Tongtai , Yao Jie 
Published: May 2022

Abstract
Introduction: Pancreatic adenocarcinoma (PAAD) is a lethal cancer, and metabolic reprogramming in PAAD is a clinical concern. The RAS oncogene family member RAB10 is highly expressed in many tumor tissues, but its role in PAAD remains unclear. Here, we explore correlations between RAB10 expression and PAAD prognosis. This study investigated whether RAB10 regulates glucose uptake in PAAD cells through modulating the expression and location of the glucose transporter1 (GLUT1).Methods: Immunohistochemical staining was used to detect the expression of RAB10 in pancreaticoduodenectomy specimens. The function of PAAD cells expressing different levels of RAB10 was assessed by CCK-8 proliferation, wound healing, and transwell migration assays. Glucose uptake assays and lactate production assays were used to explore the effects of RAB10 on PAAD cell metabolism. In addition, we used qRT-PCR, western blot, and immunofluorescence to analyze interactions between RAB10 and GLUT members.Results: RAB10 was highly expressed in PAAD tissues and cell lines, and was significantly correlated with T classification and pathological differentiation. High RAB10 expression was found to be an independent prognostic factor of poor disease outcomes in PAAD. RAB10 knockdown inhibited proliferation, invasion, and metastasis of PAAD cells, and downregulated glucose uptake and lactate production. Down-regulation of RAB10 inhibited GLUT1 translocating to the cell membrane and downregulated GLUT1 expression, which in turn decreased glucose uptake in tumor cells.Conclusion: These results demonstrate that overexpression of RAB10 is associated with worse PAAD survival outcomes. Downregulation of RAB10 may decrease glucose uptake in tumor cells by inhibiting GLUT1 membrane localization and downregulating GLUT1 expression.
Prolonged Use of Subfascial Epidural Drain and Antibiotics for Management of Thoracic Cerebrospinal Fluid Leakage
Authors: Zhai Jiliang , Guo Shigong , He Da , Zhao Yu 
Published: May 2022

Abstract
Background: Cerebrospinal fluid (CSF) leakage is a common and frustrating complication surrounding spine surgery. However, the incidence and treatment of CSF leakage after thoracic spinal surgery has seldom been reported. The aim of this study was to evaluate the efficacy of prolonged subfascial epidural drain and antibiotics to treat CSF leakage after posterior thoracic decompression surgery.Methods: A total of 121 patients, who underwent thoracic decompression between September 2012 to September 2021, were retrospectively reviewed, consisting of 56 patients with CSF leakage (Group A) and 65 without CSF leakage (Group B). Demographic data, surgical procedures, perioperative management of CSF leakage, and complications were identified from patients’ medical records. Results: In Group A, the average patient age at surgery was 52.3±11.2 years (24 to 76 years) and the average subfascial drainage time was 7.6±2.7 days (2 to 16 days). Two patients from group A underwent direct dura repair, with one of which still presenting with CSF leakage postoperatively. Four patients (7.1%) presented with deep wound infection and were successfully managed with wound debridement or intravenous antibiotics. In group B, the average patient age was 54.9±11.9 years (25 to 80 years) and the average subfascial drainage time was 3.8±1.4 days (2 to 7 days). One patient (1.5%) had a superficial wound infection and was treated with antibiotics. No patients presented with wound dehiscence, wound exudation or CSF fistulation. No significant difference in infection rate was observed between the two groups.Conclusion: No significant difference in infection rates was observed between the patients with and without thoracic CSF leakage, who were treated with different protocol. Prolonged use of subfascial epidural drain and antibiotics can effectively manage thoracic CSF leakage due to dural tear in patients after thoracic decompression surgery.