bluuebunny/crossref_metadata_2025_split huggingface dataset:
Regulation of thermoregulatory behavior by commensal bacteria in Drosophila
Authors: Suito Takuto , Nagao Kohjiro , Juni Naoto , Hara Yuji , Sokabe Takaaki , Atomi Haruyuki , Umeda Masato 
Published: June 2022

ABSTRACT
Commensal bacteria affect many aspects of host physiology. In this study, we focused on the role of commensal bacteria in the thermoregulatory behavior of Drosophila melanogaster. We demonstrated that the elimination of commensal bacteria caused an increase in the preferred temperature of Drosophila third-instar larvae without affecting the activity of transient receptor potential ankyrin 1 (TRPA1)-expressing thermosensitive neurons. We isolated eight bacterial strains from the gut and culture medium of conventionally reared larvae and found that the preferred temperature of the larvae was decreased by mono-association with Lactobacillus plantarum or Corynebacterium nuruki. Mono-association with these bacteria did not affect the indices of energy metabolism such as ATP and glucose levels of larvae, which are closely linked to thermoregulation in animals. Thus, we show a novel role for commensal bacteria in host thermoregulation and identify two bacterial species that affect thermoregulatory behavior in Drosophila.
Statistical learning in patients in the minimally conscious state
Authors: Xu Chuan , Li Hangcheng , Gao Jiaxin , Li Lingling , He Fangping , Yu Jie , Ling Yi , Gao Jian , Li Jingqi , Melloni Lucia , Luo Benyan , Ding Nai 
Published: June 2022

AbstractWhen listening to speech, cortical activity can track mentally constructed linguistic units such as words, phrases, and sentences. Recent studies have also shown that the neural responses to mentally constructed linguistic units can predict the outcome of patients with disorders of consciousness (DoC). In healthy individuals, cortical tracking of linguistic units can be driven by both long-term linguistic knowledge and online learning of the transitional probability between syllables. Here, we investigated whether statistical learning could occur in patients in the minimally conscious state (MCS) and patients emerged from the MCS (EMCS) using electroencephalography (EEG). In Experiment 1, we presented to participants an isochronous sequence of syllables, which were composed of either 4 real disyllabic words or 4 reversed disyllabic words. An inter-trial phase coherence analysis revealed that the patient groups showed similar word tracking responses to real and reversed words. In Experiment 2, we presented trisyllabic artificial words that were defined by the transitional probability between words, and a significant word-rate EEG response was observed for MCS patients. These results suggested that statistical learning can occur with a minimal conscious level. The residual statistical learning ability in MCS patients could potentially be harnessed to induce neural plasticity.
Creation and evaluation of full-text literature-derived, feature-weighted disease models of genetically determined developmental disorders
Authors: Yates T.M , Lain A , Campbell J , FitzPatrick D R , Simpson T I 
Published: June 2022

Abstract
There are &gt;2500 different genetically determined developmental disorders (DD), which, as a group, show very high levels of both locus and allelic heterogeneity. This has led to the wide-spread use of evidence-based filtering of genome-wide sequence data as a diagnostic tool in DD. Determining whether the association of a filtered variant at a specific locus is a plausible explanation of the phenotype in the proband is crucial and commonly requires extensive manual literature review by both clinical scientists and clinicians. Access to a database of weighted clinical features extracted from rigorously curated literature would increase the efficiency of this process and facilitate the development of robust phenotypic similarity metrics. However, given the large and rapidly increasing volume of published information, conventional biocuration approaches are becoming impractical. Here, we present a scalable, automated method for the extraction of categorical phenotypic descriptors from the full-text literature. Papers identified through literature review were downloaded and parsed using the Cadmus custom retrieval package. Human Phenotype Ontology terms were extracted using MetaMap, with 76–84% precision and 65–73% recall. Mean terms per paper increased from 9 in title + abstract, to 68 using full text. We demonstrate that these literature-derived disease models plausibly reflect true disease expressivity more accurately than widely used manually curated models, through comparison with prospectively gathered data from the Deciphering Developmental Disorders study. The area under the curve for receiver operating characteristic (ROC) curves increased by 5–10% through the use of literature-derived models. This work shows that scalable automated literature curation increases performance and adds weight to the need for this strategy to be integrated into informatic variant analysis pipelines.
Database URL: https://doi.org/10.1093/database/baac038
SilkBase: an integrated transcriptomic and genomic database for Bombyx mori and related species
Authors: Kawamoto Munetaka , Kiuchi Takashi , Katsuma Susumu 
Published: June 2022

Abstract
We introduce SilkBase as an integrated database for transcriptomic and genomic resources of the domesticated silkworm Bombyx mori and related species. SilkBase is the oldest B. mori database that was originally established as the expressed sequence tag database since 1999. Here, we upgraded the database by including the datasets of the newly assembled B. mori complete genome sequence, predicted gene models, bacterial artificial chromosome (BAC)-end and fosmid-end sequences, complementary DNA (cDNA) reads from 69 libraries, RNA-seq data from 10 libraries, PIWI-interacting RNAs (piRNAs) from 13 libraries, ChIP-seq data of 9 histone modifications and HP1 proteins and transcriptome and/or genome data of four B. mori-related species, i.e. Bombyx mandarina, Trilocha varians, Ernolatia moorei and Samia ricini. Our new integrated genome browser easily provides a snapshot of tissue- and stage-specific gene expression, alternative splicing, production of piRNAs and histone modifications at the gene locus of interest. Moreover, SilkBase is useful for performing comparative studies among five closely related lepidopteran insects.
Database URL: https://silkbase.ab.a.u-tokyo.ac.jp
Contemporary family screening in hypertrophic cardiomyopathy: the role of cardiovascular magnetic resonance
Authors: Huurman Roy , van der Velde Nikki , Schinkel Arend F L , Hassing H Carlijne , Budde Ricardo P J , van Slegtenhorst Marjon A , Verhagen Judith M A , Hirsch Alexander , Michels Michelle 
Published: June 2022

Abstract

Aims
Genetic testing in relatives of hypertrophic cardiomyopathy (HCM) patients leads to early identification of pathogenic DNA variant carriers (G+), before the onset of left ventricular hypertrophy. Routine phenotyping consists of electrocardiography (ECG) and transthoracic echocardiography (TTE). Cardiovascular magnetic resonance (CMR) has become valuable in the work-up of HCM. In this study, we investigated the value of CMR in phenotyping of G+ family members.

Methods and results
This study included 91 G+ subjects who underwent ECG, TTE and CMR, with a maximal wall thickness (MWT) &lt;15 mm on TTE. The relative performance of TTE and CMR regarding wall thickness measurements and HCM diagnoses was assessed. HCM was defined as MWT of ≥13 mm. Logistic regression was performed to assess whether ECG and TTE parameters can predict CMR results. Most subjects (75%) had an MWT &lt;13 mm on TTE, of which 23 (34%) were diagnosed with HCM based on CMR. MWT differences (range 1–10 mm) were often caused by an anterobasal hook-shaped thickening of the myocardium not visible on TTE. Two of 23 (9%) subjects with HCM on TTE were reclassified as no HCM on CMR. Normal ECG and TTE results almost excluded reclassifications by CMR. The prevalence of other HCM-related abnormalities on CMR was low.

Conclusion
CMR reclassified 27% of subjects. Subjects with normal ECG/TTE results were reclassified in a low number of cases, justifying screening with ECG and TTE in G+ relatives. In subjects with abnormal ECGs and/or poor TTE image quality, CMR is indicated.
Associations Between Everyday ICT Usage and (Self-)Ageism: A Systematic Literature Review
Authors: Köttl Hanna , Allen Laura D , Mannheim Ittay , Ayalon Liat 
Published: June 2022

AbstractBackground and ObjectivesBoth rapid technological changes and (self-)ageism are pervasive challenges of the 21st century, potentially affecting older adults’ everyday functioning, health, and well-being. This systematic literature review aimed to synthesize scholarly evidence to determine the associations between everyday information and communication technology (EICT) usage and (self-)ageism as well as potential moderators.Research Design and MethodsA systematic search was performed in 8 academic databases, covering the time frame from January 1995 to January 2021. Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, a total of 15 articles met the inclusion criteria and were involved in the analysis. The standardized National Heart, Lung, and Blood Institute’s quality assessment tools were used for risk bias.ResultsSeveral studies demonstrated significant associations between EICT usage and stereotype embodiment (n = 8), stereotype threat (n = 2), and age discrimination (n = 3). Age (group), gender, and motivation were examined as potential moderators.Discussion and ImplicationsThis review provides initial evidence on the associations between (self-)ageism and EICT usage. It highlights the importance of positive subjective aging perceptions for active EICT usage in older adults, but also emphasizes the detrimental consequences of ageism in EICT learning settings and technology design on older persons’ willingness and ability to use EICT. Further ecologically valid and methodologically sound research is needed to better understand both the nature and direction of the association between EICT usage and (self-)ageism.
Feasibility of a Clinical Decision Support Tool for Ustekinumab to Predict Clinical Remission and Relapse in Patients With Crohn’s Disease: A Multicenter Observational Study
Authors: Park Jihye , Chun Jaeyoung , Yoon Hyuk , Cheon Jae Hee 
Published: June 2022

AbstractBackgroundUstekinumab was recently approved for the treatment of moderate to severe Crohn’s disease (CD). Although the ustekinumab Clinical Decision Support Tool (UST-CDST) was able to predict ustekinumab responsiveness in a clinical trial, it is not clear whether UST-CDST can also predict a future clinical relapse following ustekinumab therapy in the real-life setting.MethodsWe enrolled patients with moderate to severe CD who were refractory to conventional therapies and who showed a clinical response after induction therapy with ustekinumab and monitored them until the relapse. We performed a Cox proportional hazard analysis to investigate the predictive capability of UST-CDST for a clinical disease relapse.ResultsClinical remission rates at week 20 were 25.0% for low-probability responders, 66.7% for intermediate-probability responders, and 75.0% for high-probability responders. The high-probability responders were more likely to achieve clinical remission at week 20 compared with the low-probability responders. Among 99 patients with moderate to severe CD, 37 (37.4%) experienced a clinical relapse during the median follow-up period of 18.0 months of ustekinumab treatment. The cumulative relapse rates were 70.0% in the low-probability responders, 35.9% in the intermediate-probability responders, and 22.5% in the high-probability responders (P = .001). In a multivariable Cox proportional hazard analysis, the high-probability responders and intermediate-probability responders had a lower risk of clinical relapse than the low-probability responders. Receiver operating characteristic analysis using UST-CDST to predict relapse revealed an area under the curve of 0.698.ConclusionsThe UST-CDST can predict clinical relapse in patients with moderate to severe CD subjected to ustekinumab therapy.
Strategies of Invertebrate Osmoregulation: An Evolutionary Blueprint for Transmuting into Fresh Water from the Sea
Authors: McNamara John Campbell , Freire Carolina Arruda 
Published: June 2022

SynopsisEarly marine invertebrates like the Branchiopoda began their sojourn into dilute media some 500 million years ago in the Middle Cambrian. Others like the Mollusca, Annelida, and many crustacean taxa have followed, accompanying major marine transgressions and regressions, shifting landmasses, orogenies, and glaciations. In adapting to these events and new habitats, such invertebrates acquired novel physiological abilities that attenuate the ion loss and water gain that constitute severe challenges to life in dilute media. Among these taxon-specific adaptations, selected from the subcellular to organismal levels of organization, and constituting a feasible evolutionary blueprint for invading freshwater, are reduced body permeability and surface (S) to volume (V) ratios, lowered osmotic concentrations, increased osmotic gradients, increased surface areas of interface epithelia, relocation of membrane proteins in ion-transporting cells, and augmented transport enzyme abundance, activity, and affinity. We examine these adaptations in taxa that have penetrated into freshwater, revealing diversified modifications, a consequence of distinct body plans, morpho-physiological resources, and occupation routes. Contingent on life history and reproductive strategy, numerous patterns of osmotic regulation have emerged, including intracellular isosmotic regulation in weak hyper-regulators and well-developed anisosmotic extracellular regulation in strong hyper-regulators, likely reflecting inertial adaptations to early life in an estuarine environment. In this review, we address osmoregulation in those freshwater invertebrate lineages that have successfully invaded this biotope. Our analyses show that across 66 freshwater invertebrate species from six phyla/classes that have transmuted into freshwater from the sea, hemolymph osmolalities decrease logarithmically with increasing S:V ratios. The arthropods have the highest osmolalities, from 300 to 650 mOsmoles/kg H2O in the Decapoda with 220–320 mOsmoles/kg H2O in the Insecta; osmolalities in the Annelida range from 150 to 200 mOsmoles/kg H2O, and the Mollusca showing the lowest osmolalities at 40–120 mOsmoles/kg H2O. Overall, osmolalities reach a cut-off at ∼200 mOsmoles/kg H2O, independently of increasing S:V ratio. The ability of species with small S:V ratios to maintain large osmotic gradients is mirrored in their putatively higher Na+/K+-ATPase activities that drive ion uptake processes. Selection pressures on these morpho-physiological characteristics have led to differential osmoregulatory abilities, rendering possible the conquest of freshwater while retaining some tolerance of the ancestral medium.
Developing clinical care programs: Experience from a Colombian clinical center
Authors: De la torre Alejandro , Ayola Carolina , Franco Astolfo , GONZÁLEZ MOLINA Rafael 
Published: June 2022

Abstract
Nowadays, continuous improvement in health organizations is a key determinant for enhancing the quality of care and clinical outcomes. In this article, we describe step by step the development of clinical care centers in accordance with international medical guidelines and safety standards in a Latin American country. We believe that the implementation of clinical care centers benefits the pursuit of promoting the quadruple aim: patient care, population health, cost-effectiveness and value in the provider experience.
Surgical management of a congenital arteriovenous fistula of the forearm
Authors: El Youbi Samir , Boulman Salma , Naouli Hamza , Jiber Hamid , Bouarhroum Abdellatif 
Published: June 2022

Abstract
Congenital arteriovenous fistula (AVF) is a rare vascular disease, which may occur anywhere in the body. The forearm is a very rare location. Clinical manifestations are not very specific and can vary from an asymptomatic fistula to a life-threatening congestive heart failure. Although embolization can be an alternative treatment for AVF of the forearm, surgery is still considered as the standard treatment. Herein, we report the case of a 7-year-old boy with a congenital AVF between the radial artery and the superficial cephalic vein in the forearm without any dysmorphic features treated surgically.
Jasmonate action and crosstalk in flower development and fertility
Authors: Huang Huang , Chen Yuan , Wang Shaohui , Qi Tiancong , Song Susheng 
Published: June 2022

AbstractFlower development and fertility are coordinately regulated by endogenous developmental signals, including the phytohormones jasmonates (JAs), auxin, and gibberellin, and environmental cues. JAs regulate stamen development and fertility under basal conditions, affect root growth and trichome formation under stress conditions, and control defense responses against insect herbivores and pathogens. Since the 1990s, an increasing number of studies have revealed the essential roles of JA biosynthesis, signaling, and crosstalk in regulation of flower development and fertility. Here, we summarize and present an updated overview of the JA pathway and its crosstalk in modulating flower/sexual organ development and fertility in Arabidopsis, tomato, rice, maize, and sorghum.
A geostatistical analysis of multiscale metallicity variations in galaxies – II. Predicting the metallicities of H iiand diffuse ionized gas regions via universal kriging
Authors: Metha Benjamin , Trenti Michele , Chu Tingjin , Battisti Andrew 
Published: June 2022

ABSTRACTThe metallicity of diffuse ionized gas (DIG) cannot be determined using strong emission line diagnostics, which are calibrated to calculate the metallicity of H ii regions. Because of this, resolved metallicity maps from integral field spectroscopy (IFS) data remain largely incomplete. In this paper (the second of a series), we introduce the geostatistical technique of universal kriging, which allows the complete 2D metallicity distribution of a galaxy to be reconstructed from metallicities measured at H ii regions, accounting for spatial correlations between nearby data points. We apply this method to construct high-fidelity metallicity maps of the local spiral galaxy NGC 5236 using data from the TYPHOON/PrISM survey. We find significant correlation in the metallicity of H ii regions separated by up to 0.4–1.2 kpc. Predictions constructed using this method were tested using cross-validation in H ii regions, and we show that they outperform significantly interpolation based on metallicity gradients. Furthermore, we apply kriging to predict the metallicities in regions dominated by DIG emission, considering seven additional spiral galaxies with high resolution (≲100 pc) metallicity maps. We compare kriging maps to DIG metallicities computed with novel ionization corrections, and find that such corrections introduce a systematic offset of up to ±0.1 dex for any individual galaxy, with a scatter of 0.02–0.07 dex for the sample. Overall we recommend universal kriging, together with a calibrated geostatistical model, as the superior method for inferring the metallicities of DIG-dominated regions in local spiral galaxies, demonstrating further the potential of applying geostatistical methods to spatially resolved galaxy observations.
PASSAGES: the Large Millimeter Telescope and ALMA observations of extremely luminous high-redshift galaxies identified by the Planck
Authors: Berman Derek A , Yun Min S , Harrington K C , Kamieneski P , Lowenthal J , Frye B L , Wang Q D , Wilson G W , Aretxaga I , Chavez M , Cybulski R , De la Luz V , Erickson N , Ferrusca D , Hughes D H , Montaña A , Narayanan G , Sánchez-Argüelles D , Schloerb F P , Souccar K , Terlevich E , Terlevich R , Zavala J A 
Published: June 2022

ABSTRACT
The Planck All-Sky Survey to Analyze Gravitationally-lensed Extreme Starbursts project aims to identify a population of extremely luminous galaxies using the Planck all-sky survey and to explore the nature of their gas fuelling, induced starburst, and the resulting feedback that shape their evolution. Here, we report the identification of 22 high-redshift luminous dusty star-forming galaxies (DSFGs) at z = 1.1–3.3 drawn from a candidate list constructed using the Planck Catalogue of Compact Sources and Wide-field Infrared Survey Explorer all-sky survey. They are confirmed through follow-up dust continuum imaging and CO spectroscopy using AzTEC and the Redshift Search Receiver on the Large Millimeter Telescope Alfonso Serrano. Their apparent infrared luminosities span (0.1–3.1) × 1014 L⊙ (median of 1.2 × 1014 L⊙), making them some of the most luminous galaxies found so far. They are also some of the rarest objects in the sky with a source density of ≲0.01 deg−2. Our Atacama Large Millimeter/submillimeter Array 1.1 mm continuum observations with θ ≈ 0.4 arcsec resolution show clear ring or arc morphologies characteristic of strong lensing. Their lensing-corrected luminosity of LIR ≳ 1013 L⊙ (star-formation rate ≳ 103 M⊙ yr−1) indicates that they are the magnified versions of the most intrinsically luminous DSFGs found at these redshifts. Our spectral energy distribution analysis finds little detectable active galactic nucleus (AGN) activity despite their enormous luminosity, and any AGN activity present must be extremely heavily obscured.
LMT/AzTEC observations of Vega
Authors: Marshall J P , Chavez-Dagostino M , Sanchez-Arguelles D , Matrà L , del Burgo C , Kemper F , Bertone E , Dent W R F , Vega O , Wilson G , Gómez-Ruiz A , Montaña A 
Published: June 2022

ABSTRACT
Vega is the prototypical debris disc system. Its architecture has been extensively studied at optical to millimetre wavelengths, revealing a near face-on, broad, and smooth disc with multiple distinct components. Recent millimetre-wavelength observations from ALMA spatially resolved the inner edge of the outer, cold planetesimal belt from the star for the first time. Here we present early science imaging observations of the Vega system with the AzTEC instrument on the 32-m LMT, tracing extended emission from the disc out to 150 au from the star. We compare the observations to three models of the planetesimal belt architecture to better determine the profile of the outer belt. A comparison of these potential architectures for the disc does not significantly differentiate between them with the modelling results being similar in many respects to the previous ALMA analysis, but differing in the slope of the outer region of the disc. The measured flux densities are consistent between the LMT (single dish) and ALMA (interferometric) observations after accounting for the differences in wavelength of observation. The LMT observations suggest the outer slope of the planetesimal belt is steeper than was suggested in the ALMA analysis. This would be consistent with the interferometric observations being mostly blind to structure at the disc outer edges, but the overall low signal to noise of the LMT observations does not definitively resolve the structure of the outer planetesimal belt.