bluuebunny/crossref_metadata_2025_split huggingface dataset:
Foveolar thickness as potential standardized structural outcome measurement in studies of Bietti crystalline dystrophy
Authors: Jenny Laura A. , Liu Pei-Kang , Kolesnikova Masha , Duong Jimmy , Kim Angela H. , Levi Sarah R. , Greenstein Vivienne C. , Tsang Stephen H. 
Published: August 2022

AbstractBietti crystalline dystrophy (BCD) is an ultra-rare orphan disorder that can lead to blindness. Because of the variable rates of progression of the disease, it is necessary to identify suitable outcome measurements for tracking progression in BCD. A retrospective analysis of patients with a clinical and genetic diagnosis of BCD was conducted. Four measurements of spectral domain-optical coherence tomography were compared to patients’ best corrected visual acuity. We observed that patients with higher measurements of foveolar thickness, choroidal thickness in the foveolar region, ellipsoid zone band length and the outer nuclear layer + area, had on average better visual acuity. Future studies are needed to validate the structural–functional correlations we observed in BCD and to propose a sensitive and clinically meaningful outcome measurement for tracking this rare, variable disease.
A network analysis of executive functions before and after computerized cognitive training in children and adolescents
Authors: Menu Iris , Rezende Gabriela , Le Stanc Lorna , Borst Grégoire , Cachia Arnaud 
Published: August 2022

AbstractExecutive functions (EFs) play a key role in cognitive and socioemotional development. Factor analyses have revealed an age dependent structure of EFs spanning from a single common factor in early childhood to three factors in adults corresponding to inhibitory control (IC), switching and updating. IC performances change not only with age but also with cognitive training. Surprisingly, few studies have investigated training-related changes in EFs structure. We used the regularized partial correlation network model to analyze EFs structure in 137 typically developing children (9–10 years) and adolescents (15–17 years) before and after computerized cognitive training. Network models (NMs) —a graph theory-based approach allowing us to describe the structure of complex systems— can provide a priori free insight into EFs structures. We tested the hypothesis that training-related changes may mimic developmental-related changes. Quantitative and qualitative changes were detected in the EFs network structure with age and also with cognitive training. Of note, the EFs network structure in children after training was more similar to adolescents’ networks than before training. This study provided the first evidence of structural changes in EFs that are age and training-dependent and supports the hypothesis that training could accelerate the development of some structural aspects of EFs. Due to the sample size, these findings should be considered preliminary before replication in independent larger samples.
Assessing the carbonisation temperatures recorded by ancient charcoals for δ13C-based palaeoclimate reconstruction
Authors: Mouraux C. , Delarue F. , Bardin J. , Nguyen Tu T. T. , Bellot-Gurlet L. , Paris C. , Coubray S. , Dufraisse A. 
Published: August 2022

AbstractAncient charcoal fragments, produced by the use of wood as fuel in archaeological contexts or during natural or anthropic forest fires, persist in soil and sediments over centuries to millennia. They thus offer a unique window to reconstruct past climate, especially palaeo-precipitation regimes thanks to their stable carbon isotope composition. However, the initial δ13C of wood is slightly modified as a function of the carbonisation temperature. Carbonisation-induced 13C fractionation is classically investigated through a transfer function between experimental carbonisation temperatures and the carbon content. This approach assumes that the carbon content is conservative through time in ancient charcoals and neglects the potential impact of post-depositional oxidation occurring in soils and sediments. In the present study, we first show that post-depositional oxidation can lead to a large underestimation of past carbonisation temperatures, thereby minimising the estimation of carbonisation-induced 13C fractionations and possibly biasing δ13C-based climate reconstructions. Secondly, by combining carbon content, Fourier-transform infrared and Raman spectroscopy, we propose a new framework to assess the carbonisation temperatures registered in ancient charcoals. This new framework paves the way to reassessing δ13C-based climate reconstruction.
Spectrally resolved autofluorescence imaging in posterior uveitis
Authors: Wintergerst Maximilian W. M. , Merten Nicholas R. , Berger Moritz , Dysli Chantal , Terheyden Jan H. , Poletti Enea , Holz Frank G. , Schäfer Valentin S. , Schmid Matthias , Ach Thomas , Finger Robert P. 
Published: August 2022

AbstractClinical discrimination of posterior uveitis entities remains a challenge. This exploratory, cross-sectional study investigated the green (GEFC) and red emission fluorescent components (REFC) of retinal and choroidal lesions in posterior uveitis to facilitate discrimination of the different entities. Eyes were imaged by color fundus photography, spectrally resolved fundus autofluorescence (Color-FAF) and optical coherence tomography. Retinal/choroidal lesions’ intensities of GEFC (500–560 nm) and REFC (560–700 nm) were determined, and intensity-normalized Color-FAF images were compared for birdshot chorioretinopathy, ocular sarcoidosis, acute posterior multifocal placoid pigment epitheliopathy (APMPPE), and punctate inner choroidopathy (PIC). Multivariable regression analyses were performed to reveal possible confounders. 76 eyes of 45 patients were included with a total of 845 lesions. Mean GEFC/REFC ratios were 0.82 ± 0.10, 0.92 ± 0.11, 0.86 ± 0.10, and 1.09 ± 0.19 for birdshot chorioretinopathy, sarcoidosis, APMPPE, and PIC lesions, respectively, and were significantly different in repeated measures ANOVA (p < 0.0001). Non-pigmented retinal/choroidal lesions, macular neovascularizations, and fundus areas of choroidal thinning featured predominantly GEFC, and pigmented retinal lesions predominantly REFC. Color-FAF imaging revealed involvement of both, short- and long-wavelength emission fluorophores in posterior uveitis. The GEFC/REFC ratio of retinal and choroidal lesions was significantly different between distinct subgroups. Hence, this novel imaging biomarker could aid diagnosis and differentiation of posterior uveitis entities.
Evaluation of corneal hysteresis after pars plana vitrectomy combined phacoemulsification and intraocular lens implantation
Authors: Ohta Manami , Wakuta Makiko , Sakuma Ayano , Hasegawa Mina , Hamada Waka , Higashijima Fumiaki , Yoshimoto Takuya , Ogata Tadahiko , Kobayashi Yuka , Kimura Kazuhiro 
Published: August 2022

AbstractWe evaluated the early effects of pars plana vitrectomy (PPV) on corneal biomechanics by comparing corneal hysteresis (CH) after cataract surgery (phacoemulsification and aspiration with intraocular lens implantation; PEA + IOL) alone and PPV combined with cataract surgery. This study included 20 eyes (18 patients), who underwent cataract surgery alone (PEA + IOL group), and 28 eyes (27 patients) who underwent PPV combined with cataract surgery (PPV triple group). The CH was 11.1 ± 1.1, 10.4 ± 1.1, and 11.0 ± 1.0 mmHg in the PEA + IOL group and 11.0 ± 1.4, 9.8 ± 1.4, and 10.6 ± 1.6 mmHg in the PPV triple group, preoperatively, at 2 weeks, and 3 months after surgery, respectively. The CH was not significantly different after surgery in the PEA + IOL group, but decreased significantly in the PPV triple group 2 weeks following surgery (p < 0.01). Intraocular pressure (IOP) and central corneal thickness (CCT) did not change significantly after surgery in either group. Preoperatively, there was a positive correlation between CH and CCT in the PPV triple group, but the correlation disappeared postoperatively. In PPV combined with cataract surgery, CH temporarily decreased postoperatively, independent of IOP and CCT. Removal of the vitreous may reduce the elasticity and rigidity of the entire eye.
Efficient liquid phase confiscation of nile blue using a novel hybrid nanocomposite synthesized from guar gum-polyacrylamide and erbium oxide
Authors: Hussain Daud , Khan Suhail Ayoub , Khan Tabrez Alam , Alharthi Salman S. 
Published: August 2022

AbstractIn recent times, biopolymer-metal oxide nanocomposites have gained prominent importance in the attenuation of environmental toxicants from aqueous phase. But lanthanide oxide-based biopolymer nanocomposites have scantly been evaluated for their adsorption potential. A novel guar gum-polyacrylamide/erbium oxide nanocomposite (GG-PAAm/Er2O3NC) adsorbent was synthesized by copolymerization of guar gum (GG) and acrylamide (AAm) utilizingN-N′-methylenebisacrylamide as a crosslinker and Er2O3as a reinforcing agent. The adsorptive efficacy of GG-PAAm/Er2O3nanocomposite was evaluated using nile blue (NB) as a model pollutant dye from aquatic system. The prepared adsorbent was characterized by Fourier transform infrared (FTIR) spectroscopy, X-ray diffraction (XRD) analysis, Brunauer–Emmett–Teller (BET) analysis, thermogravimetric analysis, scanning electron microscopy-energy dispersive X-ray spectroscopy (SEM–EDX), and high-resolution transmission electron microscopy (HRTEM). The optimal process parameters, which include dosage (0.8 g/L), agitation time (40 min), initial solution pH (6), and initial NB concentration (80 mg/L) were determined by batch methodology. The equilibrium data for NB confiscation was better expressed by Langmuir isotherm model, with maximal adsorption effectiveness (Qm) of 225.88 mg NB/g demonstrating the actively monolayer adsorption onto homogeneous surface of GG-PAAm/Er2O3NC. The kinetics of NB sorption process onto GG-PAAm/Er2O3NC was reliable with pseudo-second order model. Thermodynamic parameters such as ΔH°(15–17 kJ/mol) and ΔS°(0.079–0.087 kJ/mol/K), and − ΔG°(8.81–10.55 kJ/mol) for NB validated the endothermic, an increased randomness at the GG-PAAm/Er2O3–NB interface, and spontaneity and feasibility of the process, respectively. The spent nanocomposite was effectively regenerated with NaOH, and could be reused proficiently for five runs demonstrating the high reusability potential of the nanocomposite. The commendable removal efficiency and high reusability of GG-PAAm/Er2O3NC recommended it to be a highly competent adsorbent for cationic dyes particularly NB diminution from aqueous waste.
Development and validation of nomograms for predicting survival in patients with de novo metastatic triple-negative breast cancer
Authors: Chen Mao-Shan , Liu Peng-Cheng , Yi Jin-Zhi , Xu Li , He Tao , Wu Hao , Yang Ji-Qiao , Lv Qing 
Published: August 2022

AbstractMetastatic triple-negative breast cancer (mTNBC) is a heterogeneous disease with a poor prognosis. Individualized survival prediction tool is useful for this population. We constructed the predicted nomograms for breast cancer-specific survival (BCSS) and overall survival (OS) using the data identified from the Surveillance, Epidemiology, and End Results database. The Concordance index (C-index), the area under the time-dependent receiver operating characteristic curve (AUC) and the calibration curves were used for the discrimination and calibration of the nomograms in the training and validation cohorts, respectively. 1962 mTNBC patients with a median follow-up was 13 months (interquartile range, 6–22 months), 1639 (83.54%) cases died of any cause, and 1469 (74.87%) died of breast cancer. Nine and ten independent prognostic factors for BCSS and OS were identified and integrated to construct the nomograms, respectively. The C-indexes of the nomogram for BCSS and OS were 0.694 (95% CI 0.676–0.712) and 0.699 (95% CI 0.679–0.715) in the training cohort, and 0.699 (95% CI 0.686–0.712) and 0.697 (95% CI 0.679–0.715) in the validation cohort, respectively. The AUC values of the nomograms to predict 1-, 2-, and 3-year BCSS and OS indicated good specificity and sensitivity in internal and external validation. The calibration curves showed a favorable consistency between the actual and the predicted survival in the training and validation cohorts. These nomograms based on clinicopathological factors and treatment could reliably predict the survival of mTNBC patient. This may be a useful tool for individualized healthcare decision-making.
Abdominal pain patterns during COVID-19: an observational study
Authors: Balaphas Alexandre , Gkoufa Kyriaki , Colucci Nicola , Perdikis Konstantinos-Cédric , Gaudet-Blavignac Christophe , Pataky Zoltan , Carballo Sebastian , Ris Frédéric , Stirnemann Jérôme , Lovis Christian , Goossens Nicolas , Toso Christian 
Published: August 2022

AbstractAbdominal pain and liver injury have been frequently reported during coronavirus disease-2019 (COVID-19). Our aim was to investigate characteristics of abdominal pain in COVID-19 patients and their association with disease severity and liver injury.Data of all COVID-19 patients hospitalized during the first wave in one hospital were retrieved. Patients admitted exclusively for other pathologies and/or recovered from COVID-19, as well as pregnant women were excluded. Patients whose abdominal pain was related to alternative diagnosis were also excluded.Among the 1026 included patients, 200 (19.5%) exhibited spontaneous abdominal pain and 165 (16.2%) after abdomen palpation. Spontaneous pain was most frequently localized in the epigastric (42.7%) and right upper quadrant (25.5%) regions. Tenderness in the right upper region was associated with severe COVID-19 (hospital mortality and/or admission to intensive/intermediate care unit) with an adjusted odds ratio of 2.81 (95% CI 1.27–6.21, p = 0.010). Patients with history of lower abdomen pain experimented less frequently dyspnea compared to patients with history of upper abdominal pain (25.8 versus 63.0%, p < 0.001). Baseline transaminases elevation was associated with history of pain in epigastric and right upper region and AST elevation was strongly associated with severe COVID-19 with an odds ratio of 16.03 (95% CI 1.95–131.63 p = 0.010).More than one fifth of patients admitted for COVID-19 presented abdominal pain. Those with pain located in the upper abdomen were more at risk of dyspnea, demonstrated more altered transaminases, and presented a higher risk of adverse outcomes.
Attention rhythmically samples multi-feature objects in working memory
Authors: Chota Samson , Leto Carlo , van Zantwijk Laura , Van der Stigchel Stefan 
Published: August 2022

AbstractAttention allows us to selectively enhance processing of specific locations or features in our external environment while filtering out irrelevant information. It is currently hypothesized that this is achieved through boosting of relevant sensory signals which biases the competition between neural representations. Recent neurophysiological and behavioral studies revealed that attention is a fundamentally rhythmic process, tightly linked to neural oscillations in frontoparietal networks. Instead of continuously highlighting a single object or location, attention rhythmically alternates between multiple relevant representations at a frequency of 3–8 Hz. However, attention cannot only be directed towards the external world but also towards internal visual working memory (VWM) representations, e.g. when selecting one of several search templates to find corresponding objects in the external world. Two recent studies demonstrate that single-feature objects in VWM are attended in a similar rhythmic fashion as perceived objects. Here we add to the literature by showing that non-spatial retro-cues initiate comparable theta-rhythmic sampling of multi-feature objects in VWM. Our findings add to the converging body of evidence that external and internal visual representations are accessed by similar rhythmic attentional mechanisms and present a potential solution to the binding problem in working memory.
Small molecule-mediated allosteric activation of the base excision repair enzyme 8-oxoguanine DNA glycosylase and its impact on mitochondrial function
Authors: Tian Gaochao , Katchur Steven R. , Jiang Yong , Briand Jacques , Schaber Michael , Kreatsoulas Constantine , Schwartz Benjamin , Thrall Sara , Davis Alicia M. , Duvall Sam , Kaufman Brett A. , Rumsey William L. 
Published: August 2022

Abstract8-Oxoguanine DNA glycosylase (OGG1) initiates base excision repair of the oxidative DNA damage product 8-oxoguanine. OGG1 is bifunctional; catalyzing glycosyl bond cleavage, followed by phosphodiester backbone incision via a β-elimination apurinic lyase reaction. The product from the glycosylase reaction, 8-oxoguanine, and its analogues, 8-bromoguanine and 8-aminoguanine, trigger the rate-limiting AP lyase reaction. The precise activation mechanism remains unclear. The product-assisted catalysis hypothesis suggests that 8-oxoguanine and analogues bind at the product recognition (PR) pocket to enhance strand cleavage as catalytic bases. Alternatively, they may allosterically activate OGG1 by binding outside of the PR pocket to induce an active-site conformational change to accelerate apurinic lyase. Herein, steady-state kinetic analyses demonstrated random binding of substrate and activator. 9-Deazaguanine, which can’t function as a substrate-competent base, activated OGG1, albeit with a lower Emax value than 8-bromoguanine and 8-aminoguanine. Random compound screening identified small molecules with Emax values similar to 8-bromoguanine. Paraquat-induced mitochondrial dysfunction was attenuated by several small molecule OGG1 activators; benefits included enhanced mitochondrial membrane and DNA integrity, less cytochrome c translocation, ATP preservation, and mitochondrial membrane dynamics. Our results support an allosteric mechanism of OGG1 and not product-assisted catalysis. OGG1 small molecule activators may improve mitochondrial function in oxidative stress-related diseases.
Adenosine A2A receptors control synaptic remodeling in the adult brain
Authors: Xu Xinli , Beleza Rui O. , Gonçalves Francisco Q. , Valbuena Sergio , Alçada-Morais Sofia , Gonçalves Nélio , Magalhães Joana , Rocha João M. M. , Ferreira Sofia , Figueira Ana S. G. , Lerma Juan , Cunha Rodrigo A. , Rodrigues Ricardo J. , Marques Joana M. 
Published: August 2022

AbstractThe molecular mechanisms underlying circuit re-wiring in the mature brain remains ill-defined. An eloquent example of adult circuit remodelling is the hippocampal mossy fiber (MF) sprouting found in diseases such as temporal lobe epilepsy. The molecular determinants underlying this retrograde re-wiring remain unclear. This may involve signaling system(s) controlling axon specification/growth during neurodevelopment reactivated during epileptogenesis. Since adenosine A2A receptors (A2AR) control axon formation/outgrowth and synapse stabilization during development, we now examined the contribution of A2AR to MF sprouting. A2AR blockade significantly attenuated status epilepticus(SE)-induced MF sprouting in a rat pilocarpine model. This involves A2AR located in dentate granule cells since their knockdown selectively in dentate granule cells reduced MF sprouting, most likely through the ability of A2AR to induce the formation/outgrowth of abnormal secondary axons found in rat hippocampal neurons. These A2AR should be activated by extracellular ATP-derived adenosine since a similar prevention/attenuation of SE-induced hippocampal MF sprouting was observed in CD73 knockout mice. These findings demonstrate that A2AR contribute to epilepsy-related MF sprouting, most likely through the reactivation of the ability of A2AR to control axon formation/outgrowth observed during neurodevelopment. These results frame the CD73-A2AR axis as a regulator of circuit remodeling in the mature brain.
Cumulative life course adversity, mental health, and cognition in the UK biobank
Authors: Künzi M. , Gheorghe D. A. , Kliegel M. , Ballhausen N. , Gallacher J. , Bauermeister S. 
Published: August 2022

AbstractThe association between adversity and cognition varies according to the specific adversity, when the adversity was experienced, and the cognitive domains investigated. Disentangling the effect of adversity and the underlying mechanistic pathway is therefore difficult. The association between adversity (i.e., maltreatment) accumulated over the life course and cognitive flexibility, as well as two potential mediators (i.e., intra-individual variability in reaction time and depression) of this association, were investigated. Data stem from the baseline population of the UK Biobank study (N = 73,489,Mdnage = 56,SDage = 7.628, 55.740% of women). Cumulative life course adversity (specifically maltreatment) was measured with items based on the Childhood Trauma Questionnaire (CTS-5) and items adapted from the British Crime Survey. Depression was assessed with the Patient Health Questionnaire-9 (PHQ-9). Intra-individual variability in reaction time was measured with a reaction time test “snap game” and the Trail Making Test A and B were used as a measure of cognitive flexibility. A path analysis was performed on these data. Higher cumulative adverse experiences were associated with lower performance in cognitive flexibility (β = .016,p < .001, 95% CI [0.009, 0.024]), and this effect was partly mediated by the level of depression (22.727% of the total effect of cumulative life course adversity on cognitive flexibility was mediated by depression (β = .005,p < .001, 95% CI [0.004, 0.007])). No association between cumulative life course adverse experiences and intra-individual variability in reaction time was found, nor was any indirect association between cumulative life course adversity and performance in cognitive flexibility via intra-individual variability in reaction time. The association between cumulative life course adversity, depression, and performance in cognitive flexibility has been highlighted. In contrast, no indirect effect between cumulative life course adversity and performance in cognitive flexibility via intra-individual variability in reaction time was found, suggesting that it is not a potential mechanism underlying the association between cumulative life course adversity and executive function.
Linking the long-term variability in global wave energy to swell climate and redefining suitable coasts for energy exploitation
Authors: Kamranzad Bahareh , Amarouche Khalid , Akpinar Adem 
Published: August 2022

AbstractThe sustainability of wave energy linked to the intra- and inter-annual variability in wave climate is crucial in wave resource assessment. In this study, we quantify the dependency of stability of wave energy flux (power) on long-term variability of wind and wave climate to detect a relationship between them. We used six decades of re-analysis wind and simulated wave climate in the entire globe and using two 30-yearly periods, we showed that not only the previously suggested minimum period of 10 years for wave energy assessment appears to be insufficient for detecting the influence of climate variability, but also the selection period for wave energy assessment can lead to an over/underestimation of about 25% for wave power. In addition, we quantified the dependency of rates of change of wave power, wind speed and wave parameters and showed that the change in wave power is mainly a function of change in swell wave climate globally. Finally, we redefined the suitability of global hotspots for wave energy extraction using intra-annual fluctuation, long-term change, and the available wave power for the period of six decades. The results highlight the importance of climate variability in resource assessment, sustainability, and prioritizing the hotspots for future development.