bluuebunny/crossref_metadata_2025_split huggingface dataset:
An intelligent recognition method of chromosome rearrangement patterns based on information entropy
Authors: Wang Fushun , Zhang Ruolan , Sun Xiaohua , Wang Junhao , Liu Hongquan , Zhang Kang , Wang Chunyang 
Published: November 2022

AbstractChromosome rearrangements play an important role in the speciation of plants and animals, and the recognition of chromosome rearrangement patterns is helpful to elucidate the mechanism of species differentiation at the chromosome level. However, the existing chromosome rearrangement recognition methods have some major limitations, such as low quality, barriers to parental selection, and inability to identify specific rearrangement patterns. Based on the whole genome protein sequences, we constructed the combined figure according to the slope of the collinear fragment, the number of homologous genes, the coordinates in the top left and bottom right of the collinear fragment. The standardized combination figure is compared with the four standard pattern figures, and then combined with the information entropy analysis strategy to automatically classify the chromosome images and identify the chromosome rearrangement pattern. This paper proposes an automatic karyotype analysis method EntroCR (intelligent recognition method of chromosome rearrangement based on information entropy), which integrates rearrangement pattern recognition, result recommendation and related chromosome determination, so as to infer the evolution process of ancestral chromosomes to the existing chromosomes. Validation experiments were conducted using whole-genome data of Gossypium raimondii and Gossypium arboreum, Oryza sativa and Sorghum bicolor. The conclusions were consistent with previous results. EntroCR provides a reference for researchers in species evolution and molecular marker assisted breeding as well as new methods for analyzing karyotype evolution in other species.
Plasma proteomic characterization of the development of acute kidney injury in early sepsis patients
Authors: Star B. S. , Boahen C. K. , van der Slikke E. C. , Quinten V. M. , ter Maaten J. C. , Henning R. H. , Kumar V. , Bouma H. R. 
Published: November 2022

AbstractAcute kidney injury (AKI) develops frequently in the course of patients with sepsis and strongly associates with in-hospital mortality. However, diagnosing AKI involves a considerable lag-time because it depends on assessing an increase in serum creatinine, and offers no insight in the underlying pathophysiology. Consequently, identifying a set of proteins reflecting the development of AKI may improve earlier recognition of AKI and the understanding of its pathophysiology. A targeted plasma proteomic approach was performed in early sepsis patients with and without subsequent AKI development in a matched pair design (n = 19 each). Principal component analysis identified 53 proteins associated with development of AKI, which were further analysed using Enrichr gene ontology and pathway analysis. Nine differentially expressed proteins from the targeted proteomics were increased among patients who subsequently developed AKI and correlated with principal components, namely CALCA, CALR, CA12, CLEC1A, PTK7, KIM-1, NPPC, NUCB2 and PGF. We demonstrated the biological insight in the development of AKI in early sepsis compared to non-AKI sepsis.
1H-NMR metabolomic profile of healthy and osteoarthritic canine synovial fluid before and after UC-II supplementation
Authors: Stabile Marzia , Girelli Chiara Roberta , Lacitignola Luca , Samarelli Rossella , Crovace Antonio , Fanizzi Francesco Paolo , Staffieri Francesco 
Published: November 2022

AbstractThe aim of the study was to compare the metabolomic synovial fluid (SF) profile of dogs affected by spontaneous osteoarthritis (OA) and supplemented with undenatured type II collagen (UC-II), with that of healthy control dogs. Client-owned dogs were enrolled in the study and randomized in two different groups, based on the presence/absence of OA (OA group and OA-free group). All dogs were clinically evaluated and underwent SF sampling for1H-Nuclear Magnetic Resonance spectroscopy (1H-NMR) analysis at time of presentation. All dogs included in OA group were supplemented with UC-II orally administered for 30 days. After this period, they were reassessed (OA-T30). The differences in the1H-NMR metabolic SFs profiles between groups (OA-free, OA-T0 and OA-T30) were studied. The multivariate statistical analysis performed on SFs under different conditions (OA-T0 vs OA-T30 SFs; OA-T0 vs OA-free SFs and OA-T30 vs OA-free SFs) gave models with excellent goodness of fit and predictive parameters, revealed by a marked separation between groups. β-Hydroxybutyrate was identified as a characteristic compound of osteoarthritic joints, showing the important role of fat metabolism during OA. The absence of β-hydroxybutyrate after UC-II supplementation suggests the supplement’s effectiveness in rebalancing the metabolism inside the joint. The unexpectedly high level of lactate in the OA-free group suggests that lactate could not be considered a good marker for OA. These results prove that1H-NMR-based metabolomic analysis is a valid tool to study and monitor OA and that UC-II improves clinical symptoms and the SF metabolic profile in OA dogs.
Effect of climate on surgical site infections and anticipated increases in the United States
Authors: Liou Raymond J. , Earley Michelle J. , Forrester Joseph D. 
Published: November 2022

AbstractSurgical site infections (SSI) are one of the most common and costly hospital-acquired infections in the United States. Meteorological variables such as temperature, humidity, and precipitation may represent a neglected group of risk factors for SSI. Using a national private insurance database, we collected admission and follow-up records for National Healthcare Safety Network-monitored surgical procedures and associated climate conditions from 2007 to 2014. We found that every 10 cm increase of maximum daily precipitation resulted in a 1.09 odds increase in SSI after discharge, while every g/kg unit increase in specific humidity resulted in a 1.03 odds increase in SSI risk after discharge. We identified the Southeast region of the United States at highest risk of climate change-related SSI, with an estimated 3% increase in SSI by 2060 under high emission assumptions. Our results describe the effect of climate on SSI and the potential burden of climate-change related SSI in the United States.
Pediatric FEES: What It Takes to Achieve Optimal Outcomes
Authors: Harrington Bridget M. , Maybee Jennifer L. 
Published: November 2022

Purpose:
Flexible endoscopic evaluation of swallowing (FEES) in the pediatric population is an important tool for the diagnosis and intervention planning for dysphagia. This clinical focus article highlights special considerations and strategies for optimizing pediatric FEES outcomes. The results of an informal survey completed by American Speech-Language-Hearing Association Special Interest Group 13 (SIG13, Swallowing and Swallowing Disorders) members completing pediatric FEES are also presented to provide context regarding clinical practice patterns across facilities. A pediatric FEES case study is included to highlight use of supportive strategies detailed in this clinical focus article.

Conclusions:
Based on evidence and author's clinical expertise, special considerations and strategies should be incorporated into the workflow of pediatric FEES for achievement of functional results that diagnose and characterize dysphagia, directly guide dysphagia management, and improve patient/caregiver experience of the exam. Establishing a triage process for FEES candidacy is complex but sets the stage for a successful exam. Teaming of clinical staff with patient/caregiver includes collaborative preparation for the exam, establishing achievable goals and expectations, and determining supportive strategies for best patient participation.
Association Analysis of CMYA5 rs4704591 Polymorphism with Rheumatoid
Arthritis in Caucasians
Authors: Zamanpoor Mansour , Austin Natsha Anne , Ghaedi Hamid , Nograles Nadine H. , Brown Angela E. , Wilson Andrew D. , Merriman Tony R. , Morison Ian M. , Omrani Mir Davood 
Published: November 2022

Zusammenfassung
Einleitung Einzel nukleotid polymorphismen (SNPs) im
Cardiomyopathy-Associated Protein 5 (CMYA5)-Gen wurden in genomweiten
Assoziationsstudien mit rheumatoider Arthritis (RA) in Verbindung gebracht.
In dieser Studie wollten wir die Assoziation zwischen
CMYA5-Genpolymorphismen und RA in unabhängigen kaukasischen
Fall-Kontroll-Kohorten replizieren und eine Metaanalyse durchführen,
um die Assoziation von CMYA5-Genpolymorphismen mit RA in kaukasischen
Populationen zu untersuchen.
Methoden Wir analysierten 2731 RA-Fälle und 1783 gesunde
Kontrollen in vier unabhängigen kaukasischen Probensätzen.
rs4704591 im CMYA5-Gen wurden unter Verwendung des TaqMan
SNP-Genotypisierungsassays genotypisiert. Die Metaanalyse wurde über
kaukasische Kohorten hinweg durchgeführt.
Ergebnisse Unsere Analyse ergab keine Hinweise auf eine Assoziation
von rs4704591 mit RA in den Replikationsprobensätzen
(P=0,941, OR=0,997). Die Metaanalyse zeigte eine schwache
Assoziation zwischen dem kleinen Allel der CMYA5-Variante rs4704591 (C) und
RA in den kombinierten RA-Kohorten (P=0,023, OR=0,938) unter
Verwendung des logistischen Regressionsmodells in der
Matched-Case-Control-Studie.
Schlussfolgerung Unsere Studie war nicht erfolgreich darin, die
Assoziation der CMYA5-Variante rs4704591 mit RA zu replizieren. Daher
können wir die Assoziation zwischen CMYA5-Genpolymorphismen und RA
in der kaukasischen Bevölkerung nicht bestätigen.
Current German Guidelines on Diagnosis and Treatment of Secondary
Hemochromatosis in Patients with Congenital Anemias
Authors: Cario Holger , Grosse Regine , Jarisch Andrea , Oevermann Lena , Puzik Alexander 
Published: November 2022

AbstractAdequate diagnosis and treatment of secondary hemochromatosis in patients with
congenital anemias is important for reducing long-term mortality and morbidity
as for improving patients' quality of life. Due to the strong migration
movements during recent years, the number of patients in Germany suffering from
hemoglobinopathies as some of the most relevant disorders in the context of iron
overload (IOL) has increased enormously. Many of these patients had received
inadequate medical care in their countries of origin prior to migration,
including diagnosis and treatment of IOL. In parallel, various medical
developments and achievements took place, including the expansion of stem cell
transplant as curative therapeutic option and the introduction of gene therapy
for patients with hemoglobinopathies. Diagnostic tools to assess both liver and
heart IOL became available at more sites in Germany. Overall experience with
iron elimination therapy either as monotherapy or as combination of different
chelators increased. All these aspects were considered during revision of the
consensus-based guideline on the diagnosis and treatment of secondary IOL in
patients with congenital anemias (AWMF Reg. No. 025/029). Here, we
briefly summarize the procedure for the revision of the guideline, provide a
brief overview of innovations as compared to the previous version dated from
2015, and finally present the consensus recommendations adopted in the current
version.
Rivaroxaban bei tumorassoziierter venöser Thromboembolie
Authors: Bauersachs Rupert , Voigtländer Minna , Langer Florian 
Published: November 2022

ZusammenfassungDiese Übersichtsarbeit beschreibt Erkenntnisse zur Prävention und Therapie der tumorassoziierten venösen Thromboembolie (VTE) mit direkten Faktor-Xa-Inhibitoren (FXaI) und bezieht sich insbesondere auf das Studienprogramm CALLISTO mit Rivaroxaban. CALLISTO umfasst randomisierte klinische Prüfungen unterschiedlicher Fragestellungen sowie Real-World-Evidenz.Prävention und Therapie der tumorassoziierten VTE beruhten bisher auf niedermolekul1933aren Heparinen (NMH). Randomisierte kontrollierte Studien zeigten nun eine vergleichbare bis überlegene Wirksamkeit von FXaI vs. NMH. Die Erkenntnisse finden mittlerweile Eingang in Empfehlungen und Leitlinien. Zu beachten ist ein ggf. erhöhtes Blutungsrisiko, vor allem bei Patienten mit nicht resezierten gastrointestinalen oder urogenitalen Tumoren. Dieses wurde bei der Therapie mit FXaI zuerst beobachtet, kann jedoch auch NMH betreffen. Der Selektion geeigneter Patienten und der Optimierung von Behandlungspfaden kommt daher eine hohe Bedeutung zu.
Photocatalytic Cleavage of Trityl Protected Thiols and Alcohols
Authors: Murakami Sho , Brudy Cosima , Pieber Bartholomäus , Bachmann Moritz , Takemoto Yoshiji 
Published: November 2022

AbstractWe report the visible light photocatalytic cleavage of trityl thioethers or ethers under pH-neutral conditions. The method results in the formation of the respective symmetrical disulfides and alcohols in moderate to excellent yield. The protocol only requires the addition of a suitable photocatalyst and light rendering it orthogonal to several functionalities, including acid labile protective groups. The same conditions can be used to directly convert trityl-protected thiols into unsymmetrical disulfides or selenosulfides, and to cleave trityl resins in solid phase organic synthesis.
Promising Implants in Rhinoplasty
Authors: Winkler Andrew A. , Pham Tiffany T. 
Published: November 2022

AbstractMany dilemmas in rhinoplasty tempt surgeons to use exogenous materials. We have long looked toward implants to decrease operative time, to achieve a more reliable result, or when there is a paucity of autologous material. More than ever, the innovative and highly lucrative field of nasal implantology is developing technologically advanced products. This article looks at some popular nasal implant choices with a look toward what might be on the horizon.
The Need for Innovation in Rhinoplasty
Authors: Winkler Andrew A. , Chabuz Carolyn , McIntosh Cameron N. D. , Lekakis Garyfalia 
Published: November 2022

AbstractRhinoplasty is a challenging surgery and results are not always perfect. There are many obstacles to achieving optimal results. Among these are inadequate instrumentation, the unpredictability of healing, imprecise planning, and many more. Furthermore, selecting patients who can most benefit from surgery is equally important. In this article, some of the more pressing areas of rhinoplasty that need innovation are discussed. From proper patient selection, to advances in education, to the standardization of training programs, to the development of sophisticated implants, the future of rhinoplasty surgery lies in continued creativity and innovation.
Formation and functions of arbuscular mycorrhizae in coastal wetland ecosystems: A review
Authors: Wang Xing-Qiang , Wang Yan-Hong , Song Yao-Bin , Dong Ming 
Published: November 2022

ABSTRACT

Context
Coastal wetlands are ecotones interspaced by land and ocean and are among the most sensitive and vulnerable ecosystems worldwide. They are unique in hydrological, edaphic, atmospheric, and biological characteristics, and play important roles in maintaining the ecological security and ecosystem services of coastal zones. Arbuscular mycorrhizae (AM) are symbiont composed of plant roots and arbuscular mycorrhizal fungi (AMF), which are soil-borne microorganisms widely distributed in various habitats. Many previous studies on mycorrhiza have focused on terrestrial ecosystems while few on wetlands, especially coastal wetlands.

Method
We systematically reviewed previous relevant studies to explore the formation and functions of AM in coastal wetland ecosystems as well as the environmental factors that affect them. Habitat characteristics, morphological types, and species diversity of AMF in the coastal wetlands were summarized. Both responses of AMF to environmental factors during AM formation and the functions of AM in coastal wetlands were discussed.

Result
AMF are worldwide distributed in coastal wetland and are mainly limited by flooding, hypoxia, soil pH, salinity and the host plants identification. AMF play important roles in coastal wetlands, involving promoting nutrient uptake of host plants, improving the characteristics of rhizospheric soil, and enhancing plant resistance to salt and flooding stress.

Conclusion
More comprehensive studies of AMF in vitro in coastal wetlands would be helpful for the conservation and restoration of coastal wetland ecosystems in the changing world.
Data-driven fault detection of a 10 MW floating offshore wind turbine benchmark using kernel canonical variate analysis
Authors: Wang Xuemei , Wu Ping , Huo Yifei , Zhang Xujie , Liu Yichao , Wang Lin 
Published: November 2022

Abstract
Floating offshore wind turbines (FOWTs) can harvest more wind energy in deep water. However, due to their complex mechanical structure and harsh working conditions, various sensors, actuators, and components of FOWTs can malfunction and fail. To avoid serious accidents and reduce operation and maintenance costs, fault detection plays a critical role in wind-energy engineering, particularly for offshore wind energy. Because of complex characteristics, such as dynamics and nonlinearity, an accurate mathematical model cannot be easily obtained from first principles for FOWTs. In this paper, a new data-driven fault-detection method based on kernel canonical variable analysis (KCVA) is proposed for FOWTs. In the proposed method, the collected measurements are first augmented into time-lagged variables to capture the dynamics of FOWTs. The time-lagged variables are then mapped to a high-dimensional feature space to extract nonlinear features. Specifically, canonical variable analysis (CVA) is carried out to explore the correlations in high-dimensional feature space. For fault detection, two monitoring indexes including T
2 and squared prediction error (

S
P
E

) statistics are established. To verify the performance of the proposed KCVA-based fault-detection method, experiments on a high-fidelity FOWT benchmark, which was created from the National Renewable Energy Laboratory Fatigue, Aerodynamics, Structures, and Turbulence v8.0 simulator, were carried out. The results show the capability and efficiency of the proposed KCVA-based fault-detection method in comparison with other related methods.
Remaining useful life prediction for rotating machinery based on dynamic graph and spatial–temporal network
Authors: Zeng Xiangyu , Yang Chaoying , Liu Jie , Zhou Kaibo , Li Di , Wei Shangwan , Liu Yujie 
Published: November 2022

Abstract
Deep learning-based rotating machinery remaining useful life (RUL) prediction approaches rarely consider spatial dependencies and global temporal correlation of monitoring signals simultaneously. Superiorly, graph convolutional networks (GCNs) learn relationship information among graph nodes, considering the spatial dependencies of signals. It is beneficial for constructing high-quality graphs to improve the prediction performance in single-sensor monitoring scenarios. In this paper, an RUL prediction approach for rotating machinery based on a dynamic graph and a spatial–temporal network (STNet) is proposed. Short-time Fourier transform is introduced to obtain node features, and dynamic edge connections are established through node importance weights. Furthermore, an STNet is constructed to learn graph features, in which the GCN is used to mine spatial dependencies of input graphs, and a bi-directional long short-term memory network is applied to capture global temporal correlations. Finally, an autoencoder-based graph readout layer is designed to pass learned graph features. Case studies are conducted to demonstrate its effectiveness.
New evidence about the nature of plasma filaments in plasma accelerators of type plasma-focus
Authors: Pavez Cristian , Zorondo Maximiliano , Pedreros José , Sepúlveda Adolfo , Soto Leopoldo , Avaria Gonzalo , Moreno José , Davis Sergio , Bora Biswajit , Jain Jalaj 
Published: November 2022

Abstract
In this work, new evidence and information about both the origin and evolution of filamentary structures observed in the current sheath of a small plasma focus (PF) discharge are reported. The experiments were carried out in a small generator of low energy (multipurpose generator) at the PF configuration, under different operating conditions. These include different anode and insulator geometries, without return bars and in a high-performance regime of the generator at high pressures (

>

10 mbar). The evolution of the plasma structures is characterized by means of refractive optical techniques. The electrical behavior of the discharge, as well as its performance, are monitored with conventional electrical diagnostics and neutron and x-ray detectors, respectively. Plasma filaments of the same species are present in all tested configurations, however, in experiments with larger effective anode length (and smaller anode radii), the plasma region containing the filaments moves away from the anode surface and remains confined in a region of the plasma sheath, such as a toroidal plasma belt, without reaching the top of the anode nor participating in the radial compression phase. According to images of the plasma sheath in its early phase, the filaments originate and evolve from a precursor annular plasma formed in the lower part of the anode next to the insulator, during the process of electrical breakdown. The local character that these dense-filamentary structures acquire in the evolution of the plasma sheath would discard the current-filament hypothesis. On the other hand, experiments performed in deuterium gas with anodes of larger effective lengths and without filaments in the radial compression phase allowed the production of neutrons and x-rays at a high performance.
Linear simulation of kinetic Peeling-Ballooning mode with bootstrap current under the BOUT++ gyro landau fluid code
Authors: Li P F , Xu X Q , Ma C H , Snyder P B 
Published: November 2022

Abstract
The kinetic peeling-ballooning mode (KPBM) plays a crucial role in the edge turbulence and transport in a tokamak plasma. However, the impact of the bootstrap current on KPBM is still unclear. Simulations of KPBM using the BOUT++

3
+
1

gyro-Landau-fluid code are presented in this study. To investigate the KPBM in a real tokamak equilibrium, the global equilibrium solver CORSICA was employed to generate a set of realistic equilibria of shifted circular geometry, including the Shafranov shift, elongation effects and bootstrap current. The linear instability property of the KPBM is observed in a wide range of pressure gradient and parallel current density in the pedestal region. Our results indicate that the bootstrap current has a stabilizing effect on the high-n KPBM over the entire pedestal region. Here, n is the toroidal mode number. In comparison with the ideal magnetohydrodynamic peeling-ballooning mode stability diagram, the unstable KPBM region shrinks and shifts to low

β

P
G

(

β

P
G

=
(
2

μ
0

p

P
G

)

/

(

B
0
2

)

where

p

P
G

denotes the pressure at the peak pressure gradient position) with the increase of the bootstrap current. Moreover, we find that the low-n kink modes are driven unstable by the bootstrap current in the second stable region. With an additional external current drive on top of the bootstrap current, the low-n KPBMs can be stabilized when the total edge current is sufficiently large, although the low-n kink mode is still unstable in the

β

P
G

region with

β

P
G

>
0.45
%

.